bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acid-responsive lipid-coated CaCO3/Cisplatin "Watermelon-shaped" nanoparticles combined with Bmi1 siRNA reverse HCC resistance by inhibiting cancer stem cells
Authors: Li Weijie , Wang Han , Meijing Li , Sun Yan , Zhong Lijie , Li Bin , Liu Yong , Wang Fei , Yang Tan 
Published: July 2023

Abstract

Cisplatin resistance is a major obstacle in the treatment of Hepatocellular carcinoma (HCC), characterized by reduced intracellular drug accumulation and altered DNA repair/apoptosis signaling. Current strategies targeting individual factors have limited efficacy in reversing cisplatin resistance. To address this challenge, we propose a novel drug delivery system utilizing watermelon-shaped nanoparticles composed of a cisplatin core evenly distributed within a CaCO3 shell. These nanoparticles are subsequently coated with positively charged phospholipids, facilitating the absorption of Bmi1 siRNA (LCa/C@B) with the ability to inhibit HCC cancer stem cells (CSCs). In vitro and in vivo experiments demonstrate the effective release of Bmi1 siRNA and cisplatin in the slightly acidic tumor microenvironment, resulting in their uptake by drug-resistant tumor cells. LCa/C@B exhibits a synergistic effect in inhibiting CSCs, effectively reversing cisplatin chemotherapy resistance, and improving the therapeutic outcomes in HCC-resistant cells and an HCC primary mouse model. This hybrid drug delivery system, combining calcium carbonate and cisplatin with Bmi1 siRNA, presents a promising approach for overcoming chemotherapy resistance in HCC.
Sensorimotor adaptation in Virtual Reality: Do instructions and body representation influence aftereffects?
Authors: Wähnert Svetlana , Schäfer Ulrike 
Published: July 2023

Abstract
Perturbations in virtual reality (VR) lead to sensorimotor adaptation during exposure, but also to aftereffects once the perturbation is no longer present. An experiment was conducted to investigate the impact of instruction and body representation on the magnitude and the persistence of these aftereffects. Participants completed the paradigm of sensorimotor adaptation in VR. They were assigned to one of three groups: control group, misinformation group or arrow group. The misinformation group and the arrow group were each compared to the control group to examine the effects of instruction and body representation. The misinformation group was given the incorrect instruction that in addition to the perturbation, a random error component was also built into the movement. The arrow group was presented a virtual arrow instead of a virtual hand. It was hypothesised that both would lead to a lower magnitude and persistence of the aftereffect because the object identity between hand and virtual representation would be reduced and errors would be more strongly attributed to external causes. Misinformation led to lower persistence, while the arrow group showed no significant differences compared to the control group. The results suggest that information about the accuracy of the VR system can influence the aftereffects, which should be taken into account when developing VR instructions. No effects of body representation were found, and the reasons for this were discussed.
Maximal subextension and approximation of m- subharmonic function
Authors: Phu Nguyen Van , Dieu Nguyen Quang 
Published: July 2023

Abstract
In this paper, we first study subextensions in the classes Fm(Ω) and εm,χ(Ω). These results are then used to study approximation in the classes Fm(Ω) and εm,χ(Ω).
2010 Mathematics Subject Classification: 32U05, 32W20.
First systematic review and meta-analysis of the risk magnitude of climate-change effects on child health
Authors: Weeda Lewis , Bradshaw Corey , Judge Melinda , Saraswati Chitra , Souëf Peter Le 
Published: July 2023

Abstract

Children are significantly more vulnerable than adults to climate-related health threats, but studies examining how climate change affects human health have been mainly descriptive and lack an assessment of the magnitude of health effects children face. In this systematic review and meta-analysis, we searched online databasesPubMed,Medline,Embase, andWeb of Sciencefor observational studies published up to 5 January 2023 following PRISMA guidelines. We included studies if they explored climate variables/events and measured a quantifiable child-health outcome. We extracted data from published reports for a meta-analysis where we standardised effect sizes and compared them among different groupings of climate variables and health outcomes. We evaluated each study individually and aggregated and analysed relevant qualitative and quantitative data. We identified 1301 articles from the four large databases in our systematic literature review, of which 163 studies were eligible for analysis. We identified many relationships between climate change and child health, the strongest of which were increasing risk (60% on average) of preterm birth from exposure to temperature extremes. Respiratory disease, mortality, and morbidity were also influenced by climate changes, but to a lesser extent than preterm birth. The effects of different pollutants on health outcomes were considerably smaller compared to temperature effects, but with most (16/20 = 80%) pollutant studies indicating at least a weak effect. Most studies occurred in high-income regions, but we found no geographical clustering according to health outcome, climate variable, or magnitude of risk. We identified the following protective factors for climate-related child-health threats: (i) economic stability and strength, (ii) access to quality healthcare, (iii) adequate infrastructure, and (iv) food security. Threats to these services vary by local geographical, climate, and socio-economic conditions. Children will have increased prevalence and severity of disease due to anthropogenic climate change, and our quantification of the magnitude of expected increases is essential to plan for mitigation that will improve the health of current and future generations.
Sex-differences in adverse symptoms reported as side-effects by Parkinson´s disease patients receiving Deep brain stimulation (DBS) in the subthalamic nucleus
Authors: Prasad Asheeta A. , Serra Gian Pietro , Werner Lucas , Wallén-Mackenzie Åsa 
Published: July 2023

Abstract

Parkinson’s disease (PD) is a neurodegenerative disorder affecting several aspects of motor and non-motor function. Currently, no cure exists for PD. Instead, existing treatments aim to alleviate symptoms. In advanced-stage PD, Deep Brain Stimulation (DBS) is applied to relieve motor symptoms. The subthalamic nucleus (STN) is a common target area for implantation of DBS leads. While STN-DBS efficiently relieves PD motor symptoms, there have been reports of adverse side-effects. Sex-differences have been reported in a range of factors correlated with PD. However, sex-differences in patients’ experience of side-effects upon STN-DBS remain to fully uncover.
This study collated reports on adverse symptoms reported as side-effects upon STN-DBS and examined their sex distribution; biological male vs biological female. Overall, most studies had a disproportion of males to females, or did not report sex at all. 17 original articles detailing side-effects reported by PD patients upon STN-DBS, while also providing information of reporting patients´ sex, were identified and analysed. Adverse side-effects were separated into three main categories (physiological, affective, cognitive). Articles included single case reports and larger clinical cohorts to cover the range STN-DBS related symptoms. Both males and females experienced physiological side-effects, both motor and autonomic. Males reported more gait and balance side-effects while dyskinesia was reported by both males and females. Most prominent sex-difference was detected in the affective and cognitive categories. Depression was the main affective side-effect reported by females. Males, but not females, reported aggressive behavior and sexual dysfunction upon STN-DBS. An additional observation across studies was that side-effects experienced by females were less detailed.
This review of published clinical reports revealed sex-differences in adverse side-effects of STN-DBS described by PD patients and also detected sex-differences in the descriptive details of reported side-effects. These findings advocate for sex-inclusion and streamlining of data to equalize information from both sexes when reporting beneficial and adverse effects of this treatment. With lack of equal level of description across sexes, progress in treatment is hampered. Further knowledge of sex-differences will support tailor-designed treatments for improved efficacy in PD patients of both sexes undergoing, and living with, STN-DBS treatment.
Estimating the Gravitational Redshift in Galaxy Clusters and Voids Using Hernquist and Tophat Density Profiles
Authors: Wamalwa Dismas Simiyu 
Published: July 2023

Abstract
Cosmic voids happen to occupy most under dense regions of the universe. They can, therefore, be used to test our theories of structure formation and cosmology. By assuming a density profile and using it to obtain the gravitational potential, the gravitational redshift is computed. The effect is compared in two profiles of clusters and voids. From the computations, the gravitational redshift in clusters is higher than that in voids, implying that if the effect is to be considered in voids, a larger survey is required. The radii used are 20Mpc and 1Mpc for voids and clusters respectively.
Observation and model simulation of aerosol optical properties and size distribution over the hilly terrain of Northeast India
Authors: Barman Nilamoni , Kundu Shyam S , Borgohain Arup 
Published: July 2023

Abstract

The aerosol optical properties are studied at northeast India's high-altitude station. The aerosol total scattering at the station is influenced by the mountain valley wind circulation. The backward trajectory shows the pre-monsoon season is a transition period when the air mass transportation alters the direction from northwest to south direction. The dominance of biomass burning and other emissions over long-range transportation of particles contributed strongly to the aerosol loading, which caused the higher range of scattering Ångström exponent (α450−700 nm > 1.5) in the pre-monsoon, monsoon, and post-monsoon seasons. The α450−700 nm varies from 1.47 to 1.88, indicating that the fine aerosol particles with a radius of < 0.5 µm have dominance at the station. To estimate the backscatter fraction (bf) and Asymmetry Parameter (g), theoretical approximation (Sviridenkov 2017 and Kokhanovsky 2006) and model simulation (MieTab and Mieplot) are utilized. The bf and g are found to be in the range of 0.11–0.13 and 0.68 to 0.74, after comparison of this value with the model simulated particle size, observed that the radius varies from \(\approx\) 0.17 µm − 0.21 µm. The bf decreased from winter to monsoon season, while the g values enhanced, demonstrating a negative correlation. The bf value decreased owing to the less backscatter and higher forward scatter for bigger particles from winter to monsoon. Thus, the g values were smaller for higher bf values and associated with smaller aerosol particles and vice-versa.
Incidência e fatores de risco associados à depressão pós-parto em um hospital universitário do Sul do Brasil
Authors: Machado Julia Pinheiro , Botelho Lucio José , Arce Iskenderian Hugo Alejandro , Martins da Silva Amanda 
Published: July 2023

A Depressão Pós-Parto (DPP) é uma condição clínica sub diagnosticada no puerpério, porém com grande impacto na saúde pública. O artigo tem como objetivo identificar a incidência de DPP e os fatores de risco associados nas mulheres cujo parto foi realizado no Hospital Universitário de Florianópolis, e descrever seu perfil socioeconômico. Trata-se de um estudo de corte. Foram usados dois parâmetros, um socioeconômico, psicossocial e obstétrico, e a Escala de Depressão Pós-Natal de Edimburgo (EPDS) nas 48 horas pós-parto. O último foi replicado seis semanas após. Foi interpretado como provável DPP escore na EPDS ≥ 11. Foram utilizados os testes de Qui-quadrado para associação entre variáveis selecionadas como possíveis fatores de risco para DPP. A análise epidemiológica foi realizada a partir dos riscos absolutos e relativos. Resultados: 148 mulheres foram incluídas no estudo. A incidência de DPP nas 48 horas após o parto foi de 22,97%, e seis semanas após correspondeu a 31,5% da amostra. Os fatores de risco encontrados em ambos os momentos foram: diagnóstico prévio de transtorno psiquiátrico; hiperêmese gravídica na última gestação e relação perturbada com o cônjuge. Os fatores de proteção comuns incluíram satisfação com o corpo e com a notícia da gravidez. O escore ≥ 11 na EPDS no pós-parto imediato foi associado como fator de risco para o desenvolvimento de DPP seis semanas após e para o risco de causar dano a si mesma. Conclui-se que a incidência elevada de DPP está relacionada com história pregressa e fatores sociais, demonstrando a importância da investigação precoce no período perinatal, para prevenção e tratamento adequado da mesma.
Cell Physiological Behavior in the Context of Local Hypothermia
Authors: Abdullah Marzoog Basheer 
Published: July 2023

Abstract:
Local hypothermia has protective effects on injured endothelial cells, cardiomyocytes, and neurocytes. Unfortunately, the underlying mechanism of local hypothermia is still unknown. The overall effect of local hypothermia involves changes in cellular and extracellular homeostasis. Reduction in cellular metabolism is the hallmark effect of local hypothermia, resulting in a reduction in energy expenditure already impaired by starvation conditions, such as ischemia. However, on a molecular basis, local hypothermia modifies cell physiology according to the type and the vitality of the cells (brain cells are more important than skin cells; therefore, local hypothermia of the brain tissue is more critical than skin tissue, and the overall reaction of the organism is to prevent the brain from dying). This involves activating survival mechanisms, such as autophagy of brain tissue and apoptosis. The activated signaling pathways are not identical in various tissues. However, the whole machinery signaling axes have not yet been elucidated. Local hypothermia promotes the healing of the injury and improves the proliferation of regenerative tissue, but not differentiation. Hypothermia prevents the transdifferentiation of endothelial cells, neurons, and myocardiocytes. Finally, the therapeutic effects of hypothermia involve activating the nuclear factor erythroid 2-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1).
The Study of Risk Factors and The Predict Model of Cerebral Microbleeds
Authors: Lv Tao , Li Changqing 
Published: July 2023

Background:
To determine the association of cardiovascular risk factors with the presence
and anatomic location of CMBs and construct a factor-based evaluating model to predict a
high CMBs burden.

Methods:
We assessed the relation of age, male, various cardiovascular risk factors, medication
use, stroke histories and white matter hyperintensities (WMH) to the presence and location of
CMBs with univariate analysis and multiple logistic regression. Finally, we added risk factors for a
high CMBs burden to a factor-based evaluating model score.

Results:
485 patients were included in our study. CMBs were more prevalent with advanced age,
male sex, more cardiovascular risk factors and WMH. Alcohol use, hemorrhagic stroke history and
the degree of deep white matter hyperintensity (DWMH) were independent predictors for a high
CMBs burden (≥10). We finally structured a prediction model-HPSAD3 that consisted of hypertension,
alcohol use, hemorrhagic stroke history and WMH to predict a high CMBs burden. The
model-HPSAD3 has a higher positive predict value (77.08%) and negative predict value (75.89%)
to predict a high CMBs burden when the cut-off score is 4.

Conclusions:
Hypertension, alcohol use, hemorrhagic stroke history and WMH were added into
the model- HPSAD3, and there was a higher possibility of patients with CMBs ≥10 when the score
of HPSAD3 ≥4.
Silymarin Improves Thyroid Function in Lithium-treated Bipolar
Patients: A Randomized, Double-blind, Placebo-controlled Pilot Study
Authors: Ataei Sara , Mahdian Mohammad Reza , Ghaleiha Ali , Matinnia Nasrin , Nili-Ahmadabadi Amir 
Published: July 2023

Background:
Thyroid dysfunction is one of the most important side effects of lithium carbonate.
Silymarin is a flavonolignan extracted from the milk thistle Silybum marianum (L.), which has
remarkable antioxidant and therapeutic properties. This clinical trial study aimed to evaluate the effect
of silymarin on thyroid function and serum antioxidant status in patients with lithium-treated bipolar
disorder.

Methods:
Bipolar patients with a depression episode and a history of at least six months of lithium use
were randomly divided into placebo-control (n=18) and intervention (n=19) groups. In addition to
standard medication, patients in the intervention and control groups received silymarin (140 mg) and
placebo tablets daily for ten weeks, respectively. Finally, thyroid function and serum antioxidant status
were evaluated along with clinical signs at the beginning and the tenth week.

Results:
Following the administration of silymarin, a significant increase was observed in total antioxidant
capacity (p = 0.004) and total thiol molecules (p = 0.005) levels in serum compared to the placebo
group. Although silymarin had no significant effect on serum triiodothyronine (T3) and lithium
levels, it could significantly improve the secretory status of thyroid-stimulating hormone (TSH; p =
0.002) and Thyroxine (T4; p = 0.02) hormones in comparison to the placebo group.

Conclusion:
The current study showed that silymarin might be effective for thyroid function in lithium-
treated bipolar patients by improving body’s antioxidant status.

Trial Registration Number:
IRCT20190811044513N2
UAV Remote Sensing Technology: A Review of Chinese Agricultural
Patents
Authors: Bao Yudong , Huang Yongqi , Liu Yuying 
Published: July 2023

Background:
With the progress of science and technology and the advent of the new era, UAV remote sensing technology has developed rapidly in recent years and the application fields have been increasing. UAV remote sensing technology is widely used in the field of agriculture, crop growth monitoring, crop yield prediction, crop information monitoring, pest and disease detection and other aspects are more prominent.

Objective:
By analyzing and discussing the existing Chinese patents on UAV remote sensing technology, we summarize the current applications and future development prospects of UAV remote sensing technology in China's agricultural field.

Methods:
An overview of current Chinese patents on different directions of UAV remote sensing technology in the agricultural field, and an analysis of the methods used to achieve different application implementation effects.

Results:
By analyzing the existing Chinese patents on UAV remote sensing technology, we conclude that the functions they can achieve for different crops can be applied to the data collection of all crops, and analyze their characteristics to summarize future development trends.

Conclusion:
Through an in-depth study of Chinese UAV remote sensing patents in agriculture, it can be concluded that UAV remote sensing technology can achieve higher applicability and lower cost in agriculture, and for its information collection for one crop, it can be extended to apply to all crops. In the future, UAV remote sensing technology can be more easily and quickly applied to crop information acquisition in the agricultural field.
Medicinal Importance and Therapeutic Benefit of Bioactive Flavonoid Eriocitrin: An Update on Pharmacological Activity and Analytical Aspects
Authors: Patel Kanika , Patel Dinesh Kumar 
Published: July 2023

Background:Polyphenols are micronutrients and an important class of secondary metabolites that are naturally present in various types of plants and their derived byproducts. Humans obtain polyphenols and phytochemicals from different vegetables, fruits, spices, and teas. More than 8,000 different types of polyphenols have been isolated from different natural sources. Polyphenols play an important role in the plants’ resistance against pests and diseases. Plants from citrus class contain flavonoids, carotenoids, and ascorbic acid. Eriocitrin is a flavanone glycoside present in lemon juice and other citrus plants.Methods:Scientific research data on eriocitrin have been collected from Google, Google Scholar, Pub- Med, and Scopus databases, and analyzed in the present paper to determine the biological importance of eriocitrin in medicine. The medicinal importance and therapeutic benefit of eriocitrin in medicine have been investigated through literature data analysis of various research works. Pharmacological activity data have been thoroughly collected in the present work and analyzed in order to assess the health-beneficial aspects of eriocitrin against human disorders.Results:Scientific database analysis has revealed the medicinal importance and therapeutic benefit of eriocitrin in medicine. Scientific data analysis has revealed the anti-inflammatory, anti-nociceptive, and anti-obesity activities of eriocitrin. Further scientific data analysis has revealed the biological effect of eriocitrin on osteoarthritis, hepatocellular carcinoma, oral carcinogenesis, hepatic steatosis, oxidative damage, and different types of enzymes. In addition, eriocitrin has also been reported to exert potent antioxidant and suppressive effects on oxidative stress. Scientific data analysis has also revealed the significance of analytical techniques for the separation, isolation, and identification of eriocitrin.Conclusion:The present work indicates the biological importance of eriocitrin in medicine and other allied health sectors.
A Rational Approach To Antitubercular Drug Design: Molecular
Docking, Prediction of ADME Properties and Evaluation of Antitubercular Activity of Novel Isonicotinamide Scaffold
Authors: Das Paramita , Gumma Sharanakumar R. , Nayak Anjali , Menghani Sunil , Mandhadi Jithendar R. , Prabhu Padmavathi P. 
Published: July 2023

Introduction:
One of the most devastating and leading diseases is Tuberculosis (TB),
caused by Mycobacterium tuberculosis. Even though many synthetic drugs are available in the
market, to increase the therapeutic efficacy and reduce toxicity. Isoniazid is the primary drug used
in the treatment of tuberculosis.

Methods:
The main objective of the study is to perform molecular docking studies and synthesize
the derivatives of isonicotinamide along with the anti-tubercular activity. The isonicotinamide
derivatives (a-j) are prepared using isoniazid, carbon disulphate, methyl cyanide, and benzaldehyde
derivatives and characterized by TLC, IR, 1HNMR, and Mass spectroscopy. The enzyme
decaprenylphosphoryl-D-ribose oxidase (DprE1) of M. tuberculosis had good binding capacity
with all the ligands revealed in molecular docking studies. In-vitro studies indicated that all the
ligands showed anti-tuberculosis with strain M. tuberculosis.

Results:
The analysis was based on the binding energy and minimum inhibitory concentration
(MIC). The highest and lowest binding energy is -4.22 Kcal/mol (f) and -8.45 Kcal/mol (d), and
the MIC for compound d was found to be 644.22 nM. Among all the ligands, compound 5d has
the most cytotoxic effect and lower IC50 values and better bioavailability.

Conclusion:
This investigation helps in the development of better anti-tubercular therapy.