bluuebunny/crossref_metadata_2025_split huggingface dataset:
LICHTENSTEIN, TAPP, AND TEP: COMPARATIVE ASSESSMENT OF POSTOPERATIVE PAIN INTENSITY
Authors: Bulyk I. I. , Shkaraban V. P. , Vasyliuk S. M. , Huculiak S. M. , Hudyvok V. S. , Osadets V. S. , Ivanyna V. V. 
Published: July 2023

Summary. One of the indicators of choosing a method of inguinal hernia repair is the intensity of the pain syndrome. Intense postoperative pain causes discomfort in the patient, prolongs the period of physical rehabilitation and the patient’s stay in the hospital.
The aim of the study. To evaluate the intensity of postoperative pain syndrome in patients who used different methods of inguinal hernia repair: Lichtenstein, TAPP and TEP.
Research materials and methods. We performed inguinal hernia repair in 211 patients. Lichtenstein repair was performed in 65 of them (Lichtenstein group), TAPP in 81 patients (TAPP group), and TEP in 65 (TEP group). Hernia repair was carried out according to generally accepted techniques described in the literature. The patients of all groups had a standard analgesia scheme. The pain syndrome was assessed using the Visual Analogue psychometric scale.
Research results and their discussion. In the Lichtenstein group, the pain index on the first postoperative day was 5.09±1.66. On the third day, it decreased significantly (p<0.05) (r=0.28) and was 1.76±1.01. In the TAPP group, on the first postoperative day, patients rated their pain syndrome as 5.17±1.67. From the third postoperative day, the pain index decreased significantly (p<0.001) (r=0.42) and was 1.80±0.85. In the TEP group, there was a decrease in the pain syndrome index from 5.67±1.58 on the first postoperative day to 2.38±0.84 (3 days), but it was not reliable and had a weak correlation.
Conclusions. On the first postoperative day, the most uncomfortable procedure was the TEP technique. The VAS score in this group was improbably the highest compared to the Lichtenstein and TAPP groups. On the third postoperative day, there was a probable decrease in pain syndrome in the Lichtenstein and TAPP groups, and an improbable decrease in the TEP group.
THE ROLE OF APPLIED SORBENTS IN THE COMPLEX TREATMENT OF PURULENT-NECROTIC PROCESSES IN DIABETIC FOOT SYNDROME
Authors: Kryzhevs’kyy V. V. , Bilyayeva O. O. , Myronenko O. I. , Bitin’sh A. R. 
Published: July 2023

Summary. Aim. The development and implementation into clinical practice methods of local treatment of purulent-necrotic wounds in patients with diabetes, based on the use of modern sorbent drugs.
Materials and methods. In 2021, 121 patients with various stages of diabetic foot syndrome were treated. The main group included 27 patients in whom Ornidasil sorbent was used for local treatment. The comparison group included 31 patients in whom hypertonic solution and ointment bandages were used for local treatment.
Research results. The treatment of purulent-necrotic wounds in patients with type II diabetes with diabetic foot syndrome was analyzed.
Conclusions. Diabetic foot syndrome is a serious complication of diabetes. Application sorbent consisting of ornidazole and nanosilica is an effective tool in the treatment of wounds with diabetic foot syndrome.
O uso da reflexologia no tratamento da gastrite
Authors: Rossi Elizangela Beatriz , Bortolucci Thaís Helena , Hora Daisy Cristina Borges da 
Published: July 2023

Métodos alternativos têm sido utilizados há anos como forma de tratamento de doenças físicas, e dentre eles está a reflexologia podal, que consiste no estudo da ligação de plexos nervosos localizados nos pés com órgãos, sistemas e estados emocionais. O objetivo deste trabalho é descrever, por meio da revisão de literatura, a patogênese e as principais causas da gastrite, destacando os benefícios que a reflexoterapia pode gerar em indivíduos acometidos por este mal. Trabalhos científicos apontam distúrbios e doenças gastrointestinais como razões para a procura da reflexoterapia como forma de tratamento, principalmente quando relacionados ao estresse e a outras alterações emocionais. O tratamento da gastrite não deve ser considerado de forma isolada, sendo necessária uma avaliação do paciente para definir as causas envolvidas com o problema estomacal, auxiliando na escolha dos pontos-alvo destinados à realização da reflexoterapia, a fim de melhorar o funcionamento do órgão acometido, relaxando áreas e funções hiperestimuladas e reequilibrando o organismo como um todo. A gastrite pode ser detectada pela presença de uma parte endurecida ou sensível logo abaixo da pele na zona reflexa correspondente ao estômago. É indicado o estímulo desta área, das áreas de prevenção anti-inflamatórias e do plexo solar, envolvendo os pontos reflexos suprarrenal e rins, assim como do fígado. O efeito no uso da reflexoterapia podal no tratamento de doenças ou dores é positivo, sendo recomendado para complementar outro tratamento, tratar os sintomas sem diagnóstico, prevenir doenças ou mesmo diagnosticar alguma disfunção no organismo. Faz-se necessária a realização de estudos científicos que visem descrever o mecanismo de ação desta técnica no tratamento da gastrite para que ela seja cada vez mais aceita pela população em geral e pela medicina oriental, para que possa se tornar acessível por meio do sistema de saúde.
Matoa : Analogi Morfologi Buah Endemik Daerah Papua ‘Matoa’ Sebagai Inspirasi Penciptaan Karya Busana Berkolaborasi Dengan PT. Sangkara Indah Sejahtera
Authors: Santini Ni Kadek Dwika , Sudharsana Tjok Istri Ratna Cora , Diantari Ni Kadek Yuni 
Published: July 2023

Matoa merupakan tumbuhan endemik asal Papua yang tersebar hampir di seluruh daerah Papua, seperti jayapura, Wondoswaar-pulau Weoswar, Anjai Kebar, Warmare, Armina-Bintuni, Ransiki, Pami-Nuni (Manokwari), Samabusa-Nabire, serta pulau Yapen. Buah ini memiliki cita rasa yang manis dan unik, rasa buahnya seperti perpaduan lengkeng, rambutan, dan durian. Selain rasa buah yang unik dan manis, buah matoa memiliki banyak manfaat seperti dalam bidang kesehatan buah ini mengandung vitamin A, C, dan E. Oleh karena itu, penulis ingin memperkenalkan buah matoa kepada masyarakat luas melalui penciptaan busana chic look yang terinspirasi dari buah matoa. Dalam penciptaan busana chic look ini mempergunakan teori FRANGIPANI yaitu 8 tahapan penciptaan busana dan gaya ungkap analogi. Dari sepuluh metode tahapan FRANGIPANI hanya delapan metode penciptaan dijadikan sebagai landasan dalam penciptaan koleksi busana dengan ide pemantik matoa kedalam tiga jenis busana meliputi ready to wear busana pria, ready to wear deluxe busana wanita, dan semi couture busana wanita. Hasil dari penciptaan busana ini diharapkan dapat menambah pengetahuan dalam bidang fashion mengenai analogi morfologi buah matoa yang diimplementasikan ke dalam karya busana.
ANALISIS SEMIOTIKA TERHADAP ANIMASI “BELAJAR MEMBACA HURUF VOKAL DAN KONSONAN, LALA & CIKO”
Authors: Yasa Gede Pasek Putra Adnyana , Putra Gede Lingga Ananta Kusuma , Pramayasa I Made Hendra Mahajaya 
Published: July 2023

Studi ini bertujuan untuk menganalisis animasi yang berjudul “Belajar Membaca Huruf Vokal dan Konsonan, Lala & Ciko”menggunakan teori semiotika. Teori semiotika yang digunakan adalah semiotika Charles Sanders Pierce meliputi: ikon, indeks, dan simbol. Pada umunya, pembelajaran atau pesan yang disampaikan melalui bentuk video, khususnya video animasi, tentu memiliki suatu tanda di dalamnya yang dapat membantu para penontonnya untuk cepat menangkap pesan yang disampaikan. Dalam animasi, tanda tersebut bisa dibentuk pada audio, visual, karakter, maupun pendukung lainnya. Penelitian ini termasuk dalam kategori penelitian lapangan (field research) dan digolongkan sebagai penelitian deskriptif kualitatif untuk memperoleh penelitian yang akurat. Penelitian deskriptif kualitatif berupa mendeskripsikan, mencatat, menganalisis dan menginterprestasikan apa yang diteliti, melalui observasi, wawancara dan mempelajari dokumentasi. Hasil studi menunjukkan bahwa animasi “Lala & Ciko” menerapkan tanda seperti ikon, indeks dan simbol. Hampir pada keseluruhan adegan menerapkan tiga tanda tersebut. Penggunaan ikon, indeks, dan simbol memberikan dampak yang positif dalam membantu anak-anak dalam memahami, mengenal, dan menguasai keterampilan membaca huruf vokal dan konsonan secara interaktif dan menyenangkan.
Cuidando do Cuidador. Programa preventivo e terapêutico para cuidadores de idosos
Authors: Tulio Josete Cesarina , Rocha Milena Buccianti Dias da 
Published: July 2023

O cuidador do idoso é uma pessoa que se dedica à tarefa de cuidar. Entre as ações sociais da Associação Paranaense de Terapia Familiar, objetivando melhorar a qualidade de vida do cuidador por meio de práticas preventivas e fortalecimento de vínculos, o presente trabalho traz a experiência adquirida com grupos de cuidadores de idosos - familiares e profissionais. Para tanto foi gerado espaço terapêutico para grupos de cuidadores que facilite troca de experiências, construção de novas competências e possibilidades de reflexão, ressignificação de seus conflitos e aflições. Os resultados do processo em grupo foram positivos quanto a melhora na autoestima e autocuidado, melhor percepção de si mesmo, dos seus recursos, e retomada de projetos pessoais. Autocuidado e autorespeito mostraram-se aprendizados importantes, sendo um exercício que desperta um compromisso consigo próprio e com suas relações, diminuindo riscos de elevado grau de estresse e doenças comprometedoras do bem-estar físico e emocional.
A Polycrystalline Polymer Donor as Pre‐Aggregate toward Ordered Molecular Aggregation for 19.3% Efficiency Binary Organic Solar Cells
Authors: Guo Chuanhang , Fu Yiwei , Li Donghui , Wang Liang , Zhou Bojun , Chen Chen , Zhou Jing , Sun Yuandong , Gan Zirui , Liu Dan , Li Wei , Wang Tao 
Published: July 2023

AbstractOrganic semiconductors are generally featured with low structure order in solid‐state films, which leads to low charge‐transport mobility and strong charge recombination in their photovoltaic devices. In this work, a “polycrystal‐induced aggregation” strategy orders the polymer donor (PM6) and non‐fullerene acceptor (L8‐BO) molecules during solution casting with the assistance of PM6 polycrystals that are incubated through a vapor diffusion method, toward improved solar cell efficiency with either thin or thick photoactive layers. These PM6 polycrystals are redissolved in chloroform to prepare PM6 pre‐aggregates (PM6‐PA), and further incorporated into the conventional PM6:L8‐BO blend solutions, which is found to prolong the molecular organization process and enhance the aggregation of both the PM6 and the L8‐BO components. As the results, with the assistance of 10% PM6‐PA, PM6:L8‐BO solar cell devices obtain power conversion efficiencies (PCEs) from 18.0% and 16.2% to 19.3% and 17.2% with a 100 nm‐thick and 300 nm‐thick photoactive layer, respectively.
PROTOCOL: Problem solving before instruction (PS‐I) to promote learning and motivation in child and adult students
Authors: González‐Cabañes Eduardo , Garcia Trinidad , Chase Catherine , Núñez Jose Carlos 
Published: July 2023

AbstractThis is the protocol for a Campbell systematic review. The objectives are as follows: The purpose of this review is to synthesize the evidence about the efficacy of problem solving before instruction (PS‐I) to promote learning and motivation in students. Specifically, this review is designed to answer the following questions: To what degree does PS‐I affect learning and motivation, relative to alternative learning approaches? To what extent is the efficacy of PS‐I associated with the use of different design features within it, including the use of group work, contrasting cases, and metacognitive guidance in the initial problem‐solving activity, and the use of explanations that build upon students' solutions in the explicit instruction phase? To what extent is the relative efficacy of PS‐I associated with the contextual factors of activities used as control, age of students, duration of the interventions, and learning domain? What is the quality of the existent evidence to evaluate these questions in terms of number of studies included and potential biases derived from publication and methodological restrictions?
VCII based electronically tunable multi‐mode filter structure with fourth order low‐pass function for the HF band applications
Authors: Ozenli Deniz , Yesil Abdullah 
Published: July 2023

SummaryIn this paper, we propose an electronically tunable multi‐mode filter structure with fourth‐order current mode low‐pass function based on second‐generation voltage conveyor (VCII) for the analog baseband applications. The fourth‐order low‐pass circuit consists of second‐order core filter structures including band and low‐pass outputs. The proposed fourth‐order circuit's cut‐off frequency can be easily varied from 1.6 up to 17.2 MHz for the high frequency (HF) applications used in multi‐standard receivers. Also, the core circuit of the fourth‐order architecture possesses current mode and transresistance mode filter functions enabling signal conversion and different signal operations. The given architecture has 116 μm × 39 μm chip area, and post layout simulations are demonstrated extensively. In addition, the performance of the proposed structure is examined based on commercial elements (AD844s). Also, detailed linearity analysis is given using post layout extractions. In fourth‐order low‐pass structure, cut‐off frequency can be safely tuned from 1.6 up to 17.2 MHz, whereas consumed power can be reduced to 0.769 μW. It can be investigated that the proposed circuit can be safely used for the analog baseband and HF operations in wireless receivers.
Whole‐genome survey reveals extensive variation in genetic diversity and inbreeding levels among peregrine falcon subspecies
Authors: Johnson Jeff A. , Athrey Giridhar , Anderson Clifford M. , Bell Douglas A. , Dixon Andrew , Kumazawa Yoshinori , Maechtle Tom , Meeks Garrett W. , Mindell David , Nakajima Keiya , Novak Ben , Talbot Sandra , White Clayton , Zhan Xiangjiang 
Published: July 2023

AbstractIn efforts to prevent extinction, resource managers are often tasked with increasing genetic diversity in a population of concern to prevent inbreeding depression or improve adaptive potential in a changing environment. The assumption that all small populations require measures to increase their genetic diversity may be unwarranted, and limited resources for conservation may be better utilized elsewhere. We test this assumption in a case study focused on the peregrine falcon (Falco peregrinus), a cosmopolitan circumpolar species with 19 named subspecies. We used whole‐genome resequencing to generate over two million single nucleotide polymorphisms (SNPs) from multiple individuals of all peregrine falcon subspecies. Our analyses revealed extensive variation among subspecies, with many island‐restricted and nonmigratory populations possessing lower overall genomic diversity, elevated inbreeding coefficients (FROH)—among the highest reported, and extensive runs of homozygosity (ROH) compared to mainland and migratory populations. Similarly, the majority of subspecies that are either nonmigratory or restricted to islands show a much longer history of low effective population size (Ne). While mutational load analyses indicated an increased proportion of homozygous‐derived deleterious variants (i.e., drift load) among nonmigrant and island populations compared to those that are migrant or reside on the mainland, no significant differences in the proportion of heterozygous deleterious variants (i.e., inbreeding load) was observed. Our results provide evidence that high levels of inbreeding may not be an existential threat for some populations or taxa. Additional factors such as the timing and severity of population declines are important to consider in management decisions about extinction potential.
Sodium Hydroxide (NaOH)‐Mediated Oxidative Hydroxylation of Arylboronic Acids and Its Applications in C‐O Bond Formation
Authors: Yang Sen , Liu Guo‐ying , Fan Hui‐ke , Li Jun‐hua , Teng Qiao‐qiao , Chen Ming 
Published: July 2023

AbstractWe have developed a straightforward methodology for converting arylboronic acids into phenols using NaOH‐mediated air oxidation. This reaction offers several advantages, including simple operation, excellent tolerance towards various functional groups, and scalability. The transmetalation of the resulting borate ester with NaOH occurs readily, enabling convenient derivatization of the borate ester into aryl ethers and esters using alkyl and acyl halides.
Sliding mode control for the discrete cyber‐physical systems under aperiodic denial‐of‐service attacks
Authors: Zhang Ruifeng , Yang Rongni , Li Guitong 
Published: July 2023

AbstractIn this work, the problems of stability analysis and sliding mode control (SMC) for discrete‐time cyber‐physical systems (CPSs) under denial‐of‐service (DoS) attacks are investigated. Firstly, the model of aperiodic DoS attacks is established by introducing the constraints on the upper bound of the attack interval and the lower bound of the non‐attack interval. Next, by utilizing the SMC and switching strategies, the input‐to‐state stability (ISS) of the CPSs can be guaranteed in terms of the upper and lower bounds restrictions. Then, the sliding mode control law is designed for the considered CPSs. Finally, one example is given to illustrate the applicability of our proposed theoretical result.
Identifying coal mining subsidence impacts by soil moisture based on optical trapezoid model in Google Earth Engine
Authors: He Tingting , Chen Wenqi , Xiao Wu , Guo Jiwang , Chen Hang , Deng Xinyu 
Published: July 2023

AbstractMany coal mining areas overlapped with agricultural land in the world. However, surface subsidence and waterlogging brought on by coal mining inexorably harm the agricultural land. Soil moisture can reflect the variation of mining impact significantly according to the geographic features of the high underground water table, which shows significant spatial gradient variation within the subsidence basin. Previous studies have used site survey and unmanned aerial vehicle (UAV), which are not applicable to large‐scale assessments of the ecological impacts and defining the scale of impacts. Here, we used the Google Earth Engine (GEE) platform and an optical trapezoid model (OPTRAM) to estimate the soil moisture distribution around 50 mining subsidence waterbody samples in eastern China. Based on the spatial variation in soil moisture, the impact boundary of coal mining was determined using buffer analysis and trend fitting. The results showed that: (1) The OPTRAM can well reflect the soil moisture distribution which shows a good correlation between estimated and measured values, with R = 0.83 and RMSE = 0.054. (2) The spatial trend fitting of soil moisture is suitable for evaluating mining impact, and the impact distances are in the range of 96–762 m, 80% of which are located at 128–436 m. We also find that 28% of subsidence waterbody buffer basins were heavily influenced by human activities, and the coal mining impact boundaries cannot be effectively identified. The study provides a new idea to quantify the ecological and agricultural impact boundary of coal mining, which could be applied to other similar regions across the globe.
Dermatan Sulfate/Chitosan Nanoparticles Loaded with an Anti‐Inflammatory Peptide Increase the Response of Human Colorectal Cancer Cells to 5‐Fluorouracil
Authors: Blachman Agustín , Birocco Ariadna María , Curcio Sofía , Camperi Silvia Andrea , Gianvincenzo Paolo Di , Rodriguez Jésica Ayelén , Barredo‐Vacchelli Gabriela Romina , Cenci Gloria , Sosnik Alejandro , Moya Sergio , Calabrese Graciela Cristina 
Published: July 2023

AbstractThe gold standard drug for colorectal cancer (CRC) treatment, 5‐Fluorouracil (5‐FU), induces pharmacological tolerance in long‐term management. The transcriptional factor nuclear factor kappa‐light‐chain‐enhancer of activated B cells (NFκB) plays a key role in 5‐FU resistance. The aim of this work is to study the capability of polyelectrolytes complex nanoparticles of dermatan sulfate (DS) and chitosan (CS), loaded with the anti‐inflammatory tripeptide IRW, to sensitize colorectal cancer cells to 5‐FU. Fluorescence and flow cytometry studies confirmed the recognition by the nanoformulation, of the cluster of differentiation 44 (CD44) receptor, involved in the initiation and progression of colorectal tumors. Dynamic light scattering (DLS) and flow cytometry reinforced the importance of DS and CD44 receptor in the interaction, as the addition of DS or anti‐CD44 antibody blocked the binding. Moreover, the nanoformulation also interacts with 3D colon cancer cultures, namely colonospheres, enriched in cancer stem cells (CSC), subpopulation responsible for drug resistance and metastasis. To evaluate the consequences of this interaction, the subcellular distribution of the transcriptional factor NFκB, is determined by immunofluorescence analysis. Internalization and the intracellular release of IRW inhibited nuclear translocation of NFκB and increased cellular sensitivity to 5‐FU. Altogether, the nanoformulation could provide a selective delivery platform for IRW distribution to colorectal tumors, being an innovative strategy toward overcoming 5‐FU resistance in CRC therapy.
Lacticaseibacillus paracasei K71 Alleviates UVB‐Induced Skin Barrier Dysfunction by Attenuating Inflammation via Increased IL‐10 Production in Mice
Authors: Katayama Shigeru , Yamazaki Rio , Umise Hikaru , Han Hsu Pei , Mihara Toshihiro , Uchiyama Kimiko , Takahashi Hajime , Nakamura Soichiro 
Published: July 2023

ScopeUltraviolet B (UVB) radiation causes skin barrier dysfunction, leading to decreased water‐holding capacity, impaired epidermal barrier function, and increased skin thickness. This study investigates the protective effects of oral administration of Lacticaseibacillus paracasei K71 against skin barrier dysfunction in UVB‐irradiated mice.Methods and resultsMice are fed diets with or without K71 and irradiated with UVB three times a week for 12 weeks. Oral administration of K71 suppresses UVB‐induced decrease in stratum corneum water content, mitigates the increase of transepidermal water loss, and decreases epidermal thickness of the dorsal skin. Treatment with K71 reverses the upregulation of inflammatory cytokines and the activation of nuclear factor‐κB induced by UVB irradiation and upregulates the expression of anti‐inflammatory IL‐10 in the dorsal skin. Notable upregulation of IL‐10 is observed in the spleens of K71‐treated mice. K71 treatment enhances IL‐10 production in J774.1 macrophages; however, this enhancement is diminished by inhibiting K71 phagocytosis and TLR3. Furthermore, transfection using K71 RNAs significantly increases IL‐10 production.ConclusionThese results indicate that K71 may alleviate UVB‐induced skin barrier dysfunction by attenuating inflammation via increasing IL‐10 production and that K71 RNAs may induce IL‐10 production in macrophages. Therefore, K71 may be beneficial for preventing skin barrier dysfunction.