bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analyzing and predicting the urbanization and ecological resilience coupling and coordination of Guangdong Province China
Authors: Liao Zhenjie , Zhang Lijuan , Liang Shan 
Published: January 2023

AbstractRapid urbanization often leads to numerous ecological issues. Balancing development through urbanization and ecological resilience is crucial to the sustainable development of cities. Here, we combine remote sensing technology to assess urbanization and its effects on the environment from the perspective of resilience. We use the Guangdong Province China, as the study area, to build an urbanization and ecological resilience index, using a coupling coordination and relative development degree model to study the coupling coordination between the two from 2000 to 2020. The results show that (1) according to night light data the level of urbanization in Guangdong Province has increased rapidly. The Pearl River Delta metropolitan area, with Guangzhou and Shenzhen as the center, has bright lights, while the northern part of Guangdong presents many small scattered light pixels. (2) According to our indices, the level of ecological resilience in Guangdong Province has risen steadily. Maoming City has the highest level of ecological resilience in the province, followed by Jiangmen, Dongguan, Shenzhen, and Zhongshan City. (3) The coupling and coordination of urbanization and ecological resilience in Guangdong Province has been steadily improved. Qingyuan City and Shaoguan City have the highest coupling and coordination, while Zhongshan City has the largest increase in coupling and coordination. (4) The relative development of urbanization and ecological resilience in Guangdong Province has almost reached an ideal balance. (5) The model prediction results show that the coupling and coordination degree of urbanization and ecological environment in Guangdong Province will likely improve from 2021 to 2025, but the overall improvement speed will be slow. The degree of urban coupling and coordination in most cities has continued this trend of growth, upgrading to a middling level of coordinated development level.
Impact of harmonization and oversampling methods on radiomics analysis of multi-center imbalanced datasets: Application to PET-based prediction of lung cancer subtypes
Authors: Du Dongyang , Shiri Isaac , Yousefirizi Fereshteh , Salmanpour Mohammad R. , Lv Jieqin , Wu HuiQin , Zhu WenTao , Zaidi Habib , Lu Lijun , Rahmim Arman 
Published: January 2023

Abstract
Purpose To evaluate the impact of harmonization and oversampling methods on multi-center imbalanced datasets, with specific application to PET-based radiomics modeling for histologic subtype prediction in non-small cell lung cancer (NSCLC).
Methods The study included 245 patients with adenocarcinoma (ADC) and 78 patients with squamous cell carcinoma (SCC) from 4 centers. Utilizing 1502 radiomics features per patient, we trained, validated, and externally tested 4 machine-learning classifiers, to investigate the effect of no harmonization (NoH) or 4 harmonization methods, paired with no oversampling (NoO) or 5 oversampling methods on subtype prediction. Model performance was evaluated using the average area under the ROC curve (AUROC) and G-mean via 5 times 5-fold cross-validations. Statistical comparisons of the combined models against baseline (NoH+NoO) were performed for each fold of cross-validation using the DeLong test.
Results The number of cross-combinations with both AUROC and G-mean outperforming baseline in internal validation and external testing was 15, 4, 2, and 7 (out of 29) for random forest (RF), linear discriminant analysis (LDA), logistic regression (LR), and support vector machine (SVM), respectively. ComBat harmonization combined with oversampling (SMOTE) via RF yielded better performance than baseline (AUROC and G-mean of internal validation: 0.725 vs. 0.608 and 0.625 vs. 0.398; external testing: 0.637 vs. 0.567 and 0.363 vs. 0.234), though statistical significances were not observed.
Conclusion Applying harmonization and oversampling methods in multi-center imbalanced datasets can improve NSCLC-subtype prediction, but varies widely across classifiers. We have created open-source comparisons of harmonization and oversampling on different classifiers for comprehensive evaluations in different studies.
The weight-bearing pain is closest associated with physical function among different pain patterns: Data from the Osteoarthritis Initiative
Authors: Li Shilin , Zhao Yijin , Zou Jihua , Gong Ze , He Zijun , Fan Weichao , Zhang Zhuodong , Zheng Manxu , Zeng Qing , Huang Guozhi 
Published: January 2023

Abstract
Objective
To compare the correlations between different pain patterns and physical function, and identify the most related pain pattern with physical function in knee OA.
Methods
736 participants with radiological knee OA were included from the Osteoarthritis Initiative (OAI). Five pain patterns were assessed, including pain severity, intermittent, constant, weight-bearing, and non-weight-bearing pain patterns. Physical function was evaluated by the Western Ontario and McMaster Universities Arthritis Index physical function subscale (WOMAC-PF), Knee Injury and Osteoarthritis Outcome Score Function in Sport and Recreation (KOOS-FSR) and 20-Meter Walking Test (20-MWT). Linear regression analysis were used to exam the associations between pain patterns and physical function, and heat map was plotted to visualize the standardized β coefficients.
Results
Among all pain patterns, the weight-bearing pain pattern had the strongest correlation with WOMAC-PF and KOOS-FSR at baseline (β = 0.451, p < 0.001; β = -0.354, p < 0.001), year-2 follow up (β = 0.345, p < 0.001; β = -0.279, p < 0.001) and 2-year change (β = 0.430, p < 0.001; β = -0.279, p < 0.001). Except for weight-bearing pain pattern at year-2 follow up (β = 0.079, p = 0.049), pain in other linear models showed no significant correlation with 20-MWT, and weight-bearing pain was always closest to the statistical threshold value (p < 0.05).
Conclusions
Weight-bearing pain pattern was most closely associated with physical function. Therapeutic targets related to weight-bearing pain should be preferred when administering analgesic therapies to improve physical function in knee OA.
Macular Function and Morphology after Idiopathic Epiretinal Membrane Surgery correlate with the Presence of Ectopic Inner Foveal Layers
Authors: Gesualdo Carlo , Rossi Settimio , Iodice Clemente Maria , Rosolia Andrea Attilio , Corte Michele Della , Melillo Paolo , Simonelli Francesca 
Published: January 2023

Abstract
Background: To evaluate how Ectopic Inner Foveal Layers (EIFL) affect macular morphology and function after idiopathic Epiretinal Membrane (ERM) and internal limiting membrane (ILM) peeling by the means of Best-Corrected Visual Acuity (BCVA), Optical Coherence Tomography (OCT), Microperimetry (MP-1) and Multifocal Electroretinogram (mfERG).
Methods: 27 patients underwent pars plana vitrectomy with ILM and ERM peeling. They were retrospectively followed-up for 12 months and allocated into two groups basing on baseline EIFL presence (group 1) or absence (group 2). Central Retinal Thickness (CRT) and BCVA were measured and compared pre- and post-operatively at 1, 4 and 12 months, whereas Fixation Stability (FS), Macular Sensitivity (MS) and mfERG responses were confronted at baseline and 12 months.
Results: In group 1 BCVA improved (p<0.05) at 4 and 12 months (Mean difference (MD)=0.14 (SE=0.04); MD=0.13 (SE=0.05), respectively) as well as in group 2 (MD=0.31 (SE=0.07): MD=0.41 (SE=0.08), respectively). CRT did not change in group 1, whereas it decreased (p<0.05) in group 2 at 4 and 12 months (MD=-73.13 – SE=23.56; MD=-76.20 – SE=23.56). MS showed no changes in both groups after surgery. FS did not change in group 1, whereas group 2 improved (p<0.05) in either FS2° (+8.91±13.97) and FS4° (+4.33±3.84) at 12 months. MfERG P1 wave did not improve in group 1, while group 2 improved (p<0.001) postoperatively (αP1-2: 27.97±27.62; αP1-3: 12.51±17.36; αP1-4: 10.49±17.19) except from the most central ring (αP1-1).
Conclusion: EIFL presence resulted to negatively affect the outcomes of this procedure.
Quantifying the hazard from volcanic sulphur dioxide to aircraft occupants
Authors: Kristiansen Nina , Witham Claire , Beckett Frances 
Published: January 2023

Abstract

Volcanic eruptions can emit large quantities of sulphur dioxide (SO2) into the atmosphere, which can be harmful to people and the environment. Aircraft encounters with a volcanic SO2 cloud could represent a health hazard to crew and passengers onboard, depending on the dose of SO2 encountered. The recommended SO2 concentration threshold set by the World Health Organisation (WHO) is 500 µg/m3 over 10 minutes. In this study we have assessed concentration levels of volcanic SO2 in the atmosphere following eight historic eruptions and use dispersion model simulations to calculate when and where the WHO threshold is exceeded. The time and area of exceedance varies and depends on the eruption characteristics: the amount, duration and height of the SO2 release. The WHO threshold is exceeded for all historic eruptions considered. In several cases, the area delineated by the WHO threshold, that is the SO2 hazard, can be considerably larger than the volcanic ash hazard area for the same eruption. SO2 hazard areas also often extend over a longer period of time compared to the equivalent ash advisories. For example, following the 2019 eruption of Raikoke, the SO2 hazard area reached up to 1.7 million km2 and the WHO concentration value was exceeded for about two weeks, while volcanic ash was considered hazardous to aviation for about five days. These results will help the aviation industry to better understand the potential risks to their passengers and crew from volcanic SO2, and aid in defining concentration thresholds for any potential volcanic SO2 forecasts for aviation.
A newly synthesized organic chromophore (HCzN) showing optical linear and nonlinear response for potential in photonic applications
Authors: Ali Abid , Mehkoom Mohd , Ali Farman , Afzal S. M. , Ahmad Shabbir 
Published: January 2023

Abstract
The present article demonstrates the optical linear and nonlinear studies of the chromophore 2,2'-(hexane-1,6-diylbis(9H-carbazole-9,3-diyl))bis(ethene-1,1,2-tricarbonitrile (HCzN). We have synthesized this molecule and the structure of this molecule has been confirmed via IR and NMR spectroscopies. The linear optical study has been done with the help of UV-Vis absorption and emission spectroscopies and we have measured the refractive index (n0), and optical bandgap (Eg) for this chromophore. We have explored the third-order nonlinear optical (NLO) characteristics of HCzN at the concentrations of 1, 2, 3, and 4 mM employing both closed and open-aperture Z-scan methods at 25 mW laser power. This chromophore evinces the self-defocusing and saturable absorption nature for closed and open aperture scans respectively. The calculated NLO parameters like the coefficient of nonlinear absorption (β) and refraction (n2) are found to be of the order of 10− 6 cm2/W and 10− 3 cm/W respectively with the nonlinear optical susceptibility (χ(3)), and hyperpolarizability (γ) of the order of 10− 5 esu, and 10–27 esu respectively. The magnitude of NLO parameters varies linearly with concentration.
Reducing CNOT count in quantum Fourier transform with linear nearest-neighbor architecture
Authors: Park Byeongyong , Ahn Doyeol 
Published: January 2023

Abstract
The physical limitations of quantum hardware often require nearest-neighbor architecture. Generally, two-qubit gates are needed to transform a quantum circuit into a circuit with nearest-neighbor architecture. However, two-qubit gates are considered the primary cost of quantum circuits because of their higher error rates and longer execution time than single-qubit gates. The controlled-NOT (CNOT) gate is the typical choice of a two-qubit gate. Here, we propose a new linear nearest-neighbor circuit design protocol of quantum Fourier transform (QFT), one of the most versatile subroutines in quantum algorithms. Compared with previous studies on n-qubit QFT circuits with nearest-neighbor architecture, our method reduces the number of CNOT gates by up to ~ 40%. Next, we put our QFT circuits and standard QFT circuits in the Qiskit transpiler to construct QFTs on the IBM quantum computers. As a result, we show that our QFT circuits have a significant advantage over standard QFT circuits in terms of the number of CNOT gates. These results suggest that the proposed protocol can be a new starting point for building QFT circuits implemented in quantum hardware demanding nearest-neighbor architecture.
Automated Epileptic Seizure Detection by Using MLP-GA Model
Authors: Chanu Maibam Mangalleibi , Singh Ngangbam Herojit , Thongam Khelchandra 
Published: January 2023

Abstract
One of the most often utilized signals for assessing the electrical activities of the brain is the Electroencephalograph (EEG) signal. The manual approach of determining epileptic irregularities is time-consuming, and the outcome may vary depending on the reader's level of expertise. In order to identify seizures from EEG signals, this research introduces a unique computer-aided approach that uses hybrid machine learning techniques. Discrete Wavelet Transform is used to extract features from the signals (DWT). A classifier is utilized to distinguish between the normal and seizure classes using a mix of the Self Organizing Neural Network (SONN) and Multilayer Perceptron (MLP) method. The performance of the suggested strategy produced a 99.8 % accuracy.
Simulating future land cover change in the Tono catchment using the CA-Markov model
Authors: Atulley Joan A. 
Published: January 2023

Abstract
Land use change is the most precise method used to understand the past and future land use dynamics of an area. Based on historical land use change, this study simulated the spatial patterns of land use in 2030, 2040, and 2050 using the CA-Markove model in Tersset. Land use classification maps from 1986, 1996, 2006, and 2020 were used in the Markov chain analysis to predict future maps. The simulated land cover map for 2020 was validated by comparing it with the classified map of the same year. The Overall Kappa value was 0.8878, indicating satisfactory performance. Future land use changes were quantitatively and spatially analyzed and the results revealed an increase in farmland from 38.7% in 2030 to 53.1% in 2050 to the detriment of savannah forest and Savanah Woodland, which is projected to decline from 21.7–13.4% and 33.0–22.2% respectively within the same period. The major transitions that occurred over the study period include, transition from farmland to savannah woodlands and savannah forest to savannah woodlands. Savannah forest persisted in the Northern part of the catchment and along the rivers. Conversion from savannah forest to farmland was observed to be prominent around the Tono reservoir, which is cause for concern. Hence, timely management measures need to be taken by policymakers to protect and sustainably manage forest resources in the catchment to safeguard water resources downstream. Study findings provide a scientific basis for decision-making for the catchment’s forest-water resources management.
Identification of autophagy-related genes for regulating cancer stem cell characteristics in colon adenocarcinoma by the analysis of transcriptome data stemness indices
Authors: Guo Peijie , Hou Weiye , He Bangshun , Sun Bojie , Nie Zhenlin , Peng Hongxin , Lin Kang , Gao Tianyi , Xie Haiwei 
Published: January 2023

Abstract
The emergence of cancer stem cells (CSCs) is the barrier to effective clinical outcomes for Colon adenocarcinoma (COAD) patients. Autophagy was found to play an important role on CSCs stemness regulation. However, the specific role of autophagy-related genes in COAD stemness remains unclear. In this study, by processing on two independent stemness indices, mRNAsi and mDNAsi, TP53INP2 among 29 differentially expressed autophagy-related genes(ARGs) in COAD was identified to be the hub ARGs in COAD stemness elimination. COAD patients with high stemness indices scores usually showed a down-regulated TP53INP2 expression which was correlated to a higher chemotherapy resistance and poorer RFS than the others. Two TFs, KLF9 and SETBP1 were involved in CSCs TP53INP2 expression promotion. Additionally, the decreased expression level of TP53INP2 was found to be significantly correlated to the COAD immune subtypes of C4 which contributed to the immunoresistance with low density infiltration of TH2, Treg cells, macrophages, monocyte and dendritic cells. In conclusion, TP53INP2 was found to be a valid indicator for poor prognosis of COAD patients with high stemness. All these results would provide a new strategy in seeking potential COAD therapeutic targets.
The optimal puncture time point of prolonged occlusion flow-mediated dilatation in radial artery catheterization: A prospective observational study
Authors: Qi Wensheng , Ma Haichun , Wu Xuehan , Wei Kun , Li Yanhui 
Published: January 2023

Abstract
This study aimed to evaluate the degree and duration of the radial artery dilation after PO-FMD, and the time point at which the radial artery diameter is expanded to the maximum. This was a prospective observational study. According to the Chinese guideline on the primary prevention of cardiovascular diseases (CVD), 142 patients awaking from general anesthesia were divided into two groups: low-risk (LR) group and high-risk (HR) group. Firstly, the baseline radial artery diameter was measured on the left wrist using ultrasound in both groups. Subsequently, the radial artery diameters were obtained continuously at the same location for 5 minutes after PO-FMD. The baseline radial artery diameter, the maximum radial artery diameter, and the duration of radial artery dilation in the two groups were recorded. The time point at which the radial artery diameter is expanded to the maximum in the LR group and HR group was 26.49 ± 11.69s and 46.27 ± 12.03s, respectively(P༜0.01). The time of radial artery dilation and the percentage changes in arterial diameter in HR group were significantly lower than LR group (duration time: mean [mean ± standard]: 136.65 ± 31.55s vs. 168.98 ± 33.27s; percentage changes: median [interquartile range] 10.5 [8.6, 12.9] % vs. 15.2 [12.4, 19.0] %). In this study, the optimal puncture time point of PO-FMD in the LR group was 26s, and in the HR group was 46s. It would be helpful to guide the time point in radial artery catheterization after PO-FMD. Chinese Clinical Trial Registry identifier: ChiCTR2200066214.
Determination of Xerostomia with Cutoff Value for Salivary Flow Rate using Machine Learning Algorithm
Authors: Lee Yeon-Hee , Auh Q-Schick , Park Hee-Kyung 
Published: January 2023

Abstract
Aim
The purpose of this study was to investigate the objective cut-off values of unstimulated (UFR) and stimulated salivary flow rates (SFR) in patients with xerostomia and to present optimal machine learning model with A Classification and Regression Tree (CART) for all ages.
Methods
A total of 829 patients with oral diseases were enrolled (591 females; mean age, 59.29 ± 16.40 years; age range, 8–95 years old), 199 patients with xerostomia and 630 patients without xerostomia. Clinical characteristics were collected and analyzed together. To investigate which oral and systemic factors affect the presence of xerostomia and the cutoff value of UFR and SFR, the CART machine learning algorithm was repeatedly performed.
Results
UFR (0.41 ± 0.24 vs. 0.29 ± 0.22 mL/min, p < 0.001) and SFR (1.39 ± 0.94 vs. 1.12 ± 0.55, p < 0.001) were significantly lower in Xerostomia than in non-Xerostomia. The presence of xerostomia had a significant negative correlation with both UFR (r=-0.603, p-value < 0.01) and SFR (r=-0.301, p-value < 0.05). Considering the magnitude of the correlation coefficient, the presence of xerostomia in the patients with oral diseases showed a stronger correlation with the decrease in UFR than with the decrease in SFR. In the diagnosis of xerostomia based on the CART machine learning algorithm, the presence of stomatitis, candidiasis, halitosis, psychiatric disorder, and hyperlipidemia were significant predictors for xerostomia. According to the type of parameters included in each CART algorithm, the cutoff values of UFR and SFR were different, and the specific ranges with significant results are as follows; the UFR of 0.03 ~ 0.18 mL/min, SFR of 0.85 ~ 1.6 ml/min.
Conclusion
For the diagnosis of xerostomia, a new comprehensive approach was made using an optimal CART algorithm considering salivary hyposalivation and oral/systemic conditions. Xerostomia was negatively correlated with UFR and SFR values, and cut-off values for salivary flow rates varied depending on the underlying clinical factors of the patients.
Surgical outcome after thoracoscopic lung resections for congenital lung lesions in children
Authors: Musters Gijsbert D. , de Beer Sjoerd A. , Schuppen Joost van , de Jong Justin R , Gorter Ramon R , Oomen Matthijs W 
Published: January 2023

Abstract

Purpose: This study aimed to determine the complications after video assisted thoracoscopic surgery (VATS) for congenital lung lesions in children.
Methods: All children undergoing a lung resection between January 2009 and June 2022 were retrospectively identified. Both early (<30 days) and late postoperative pulmonary complications were determined. The primary endpoint was postoperative complications within 30 days.
Results: In total, 56 patients were included, with a median age of 13 months (IQR 9-37). A VATS lobectomy were performed in 46 patients (82%), an extralobar sequestration in 8 patients (14%), an wedge resection in 1 patient and a segment resection in 1 patient. During the COVID pandemic, less resections were performed with an increase in symptomatic patients. A conversion to open occurred in 6 patients (11%), of which a preoperative lung infection was associated with an increased risk thereof (p=0.004). The median follow-up was 22 months (IQR 7-57) and all patients were alive. A postoperative complication (Clavien Dindo ≥3) occurred in 9 patients and complications without the need of intervention in 6 patients.
Conclusion: VATS lobectomy is a relatively safe procedure in children, even under one year of age. A preoperative lung infection increases the risk of conversion to open surgery.
Feature Compensated Adaptive Fusion Shuffle Network for Image Super-Resolution Reconstruction
Authors: Zhao Xiaoqiang , Li Xiyao 
Published: January 2023

Abstract
Recently, deep networks with multiple branches or different filtering methods have achieved good performance in image super-resolution, however, they ignore the fact that some high-frequency components are lost during multiple captures of contextual information by a single branch. To solve this problem, we propose a feature-compensated adaptive fusion shuffle network (CAFN) for image super-resolution. Specifically, we propose a feature-compensated shuffle model (FCSM). It uses branch compensation to compensate for the high frequency information lost by single channel feature transfer. Then, we propose an attention adaptive compensation fusion module (ACFM), which adaptively learns the weight information about the channel structure, and improves the branch compensation method to better adapt to the learned weight information. ACFM can further capture contextual dimension information and extract more high-frequency features. Experimental results show that our proposed CAFN has an excellent performance in terms of both visual results and evaluation metrics.