bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transmembrane protein 135 regulates lipid homeostasis through its role in peroxisomal DHA metabolism
Authors: Landowski Michael , Bhute Vijesh J. , Grindel Samuel , Haugstad Zachary , Gyening Yeboah K. , Tytanic Madison , Brush Richard S. , Moyer Lucas J. , Nelson David W. , Davis Christopher R. , Yen Chi-Liang Eric , Ikeda Sakae , Agbaga Martin-Paul , Ikeda Akihiro 
Published: January 2023

AbstractTransmembrane protein 135 (TMEM135) is thought to participate in the cellular response to increased intracellular lipids yet no defined molecular function for TMEM135 in lipid metabolism has been identified. In this study, we performed a lipid analysis of tissues from Tmem135 mutant mice and found striking reductions of docosahexaenoic acid (DHA) across all Tmem135 mutant tissues, indicating a role of TMEM135 in the production of DHA. Since all enzymes required for DHA synthesis remain intact in Tmem135 mutant mice, we hypothesized that TMEM135 is involved in the export of DHA from peroxisomes. The Tmem135 mutation likely leads to the retention of DHA in peroxisomes, causing DHA to be degraded within peroxisomes by their beta-oxidation machinery. This may lead to generation or alteration of ligands required for the activation of peroxisome proliferator-activated receptor a (PPARa) signaling, which in turn could result in increased peroxisomal number and beta-oxidation enzymes observed in Tmem135 mutant mice. We confirmed this effect of PPARa signaling by detecting decreased peroxisomes and their proteins upon genetic ablation of Ppara in Tmem135 mutant mice. Using Tmem135 mutant mice, we also validated the protective effect of increased peroxisomes and peroxisomal beta-oxidation on the metabolic disease phenotypes of leptin mutant mice which has been observed in previous studies. Thus, we conclude that TMEM135 has a role in lipid homeostasis through its function in peroxisomes.
Novel constituents of Salvia hispanica L. (chia) nutlet mucilage and the improved in vitro fermentation of nutlets when ground
Authors: Ang Main Ern , Cowley James M. , Yap Kuok , Hahn Michael G. , Mikkelsen Deirdre , Tucker Matthew R. , Williams Barbara A. , Burton Rachel A. 
Published: January 2023

The gel-like nutlet mucilage of chia (Salvia hispanica L.) is a complex network of several polymers. These dietary fibres protect chia nutlets from microbial fermentation but grinding the seeds improves fermentation and access to other key nutrients.
Exploring the Cognitive-Communication Challenges of Adults With Histories of Traumatic Brain Injury and Criminal Justice System Involvement: A Pilot Study
Authors: Wiseman-Hakes Catherine , Magor Tamsin , Bauman Nicole , Colantonio Angela , Matheson Flora I. 
Published: January 2023

Introduction:
The prevalence of traumatic brain injury (TBI) in the criminal justice system (CJS) is well known. Furthermore, the impact of TBI on communication has been well documented; however, no study has explored the communication challenges of those with TBI in the CJS or considered their implications within CJS contexts. Moreover, no study has examined the possible differences in communication between those with TBI and CJS history and those with TBI but no CJS history.

Purpose:
This cross-sectional pilot study provides a preliminary exploration of the cognitive-communication challenges in a sample of adults with histories of TBI and CJS involvement compared with a sample of adults with histories of TBI but no CJS involvement.

Method:
Eight individuals with histories of TBI and CJS involvement were recruited through community agencies. The La Trobe Communication Questionnaire (LCQ) was administered to collect self-reported data on perceived cognitive-communication abilities, including social communication behaviors. Findings were examined and then compared with a previously studied sample of 160 individuals with TBI. Logistic regressions were calculated to determine whether response scores on the LCQ would be predictive of group membership (i.e., TBI + CJS or TBI only).

Results:
A range of cognitive-communication challenges were reported by both groups. A logistic regression analysis demonstrated a reasonable inference that LCQ responses may predict group membership and support the potential for statistically significant and meaningful results to justify future studies.

Conclusions:
These challenges have the potential to negatively impact the success of communication interactions within the CJS and illustrate a need for speech-language pathology services for individuals with TBI in the CJS. The nature and magnitude of between-group differences merits further investigation with larger samples to explore whether any specific cognitive-communication challenge is unique to, or predictive of, CJS involvement for purposes of targeted assessment and intervention.
Applicability of the acoustic–electrical joint detection method to identify defects in gas insulated system
Authors: Sun Jixing , Fan Yongzhi , Qiu Weifan , Song Sibo , Tan Xinyu , Tian Yu , Jiao Xuewen , Wang Huili , Wu Nana 
Published: January 2023

AbstractThere are many defects in gas‐insulated metal‐enclosed switchgear (GIS) and gas‐insulated transmission lines (GIL) that may cause accidents, such as floating potentials, metal particles, air gaps, and cracks in support insulators. Nevertheless, to‐this‐date, there is no effective method to recognize them to adjust their operation status. Accordingly, this study compared three typical defect models to explore the partial discharge process, and three typical experimental models were established to identify the characteristic parameters of acoustic and electrical information in the development of defects. The research study shows that that as the voltage increases, the partial discharge of free‐metal‐particle defects and air‐gap defects obtained by the pulse‐current method increase gradually. A sudden increase also occurred in the partial discharge of the floating potential defect. The discharge amount of free conductive particles obtained by an ultrahigh‐frequency detection method was distributed symmetrically on both sides of the applied voltage peak, and the other two defects were on one side of the peak and yielded an obvious phase difference. The particle collision signal obtained by the ultrasonic method was obvious, but had no obvious phase relationship with the applied voltage. However, the obtained floating potential defect information had obvious phase differences, and the ultrasonic method was not sensitive to air‐gap defects. The three typical defects can be identified by the combined method more accurately; this provides a theoretical basis and data support for GIS and GIS voltage tests, detection technologies, and online monitoring methods.
Cosmic rate of type IIn supernovae and its evolution with redshift
Authors: Cold C. , Hjorth J. 
Published: January 2023

Context. Type IIn supernovae potentially constitute a large fraction of the gravitationally lensed supernovae predicted to be found with upcoming facilities. However, the local rate is used for these estimates, which is assumed to be independent of properties such as the host galaxy mass. Some studies hint that a host galaxy mass bias may exist for IIn supernovae.
Aims. This paper aims to provide an updated local IIn supernova-to-core-collapse ratio based on data from the Palomar Transient Factory (PTF) and the Zwicky Transient Facility (ZTF) Bright Transient Survey (BTS). Furthermore, the goal is to investigate the dependency of the IIn supernova peak magnitude on the host galaxy mass and the consequences of a possible host galaxy mass preference on the volumetric rate of type IIn supernovae.
Methods. We constructed approximately volume-limited subsamples to determine the local IIn supernova-to-core-collapse ratio. We investigated the absolute peak magnitude of a subsample of type IIn and superluminous II or IIn supernovae exploring how this relates to the i-band magnitude of the host galaxies (as a proxy for stellar mass). We presented a method to quantify the effect of a potential preference for low-mass host galaxies utilizing the UNIVERSEMACHINE algorithm.
Results. The IIn supernova-to-core-collapse ratios for PTF and BTS are 0.046 ± 0.013 and 0.048 ± 0.011, respectively, which results in a ratio of 0.047 ± 0.009, which is consistent with the ratio of 0.05 currently used to estimate the number of gravitationally lensed IIn supernovae. We report fainter host galaxy median absolute magnitudes for type IIn brighter than −20.5 mag with a 3σ significance. If the IIn supernova-to-core-collapse ratio were described by the power law model IIn/CC = 0.15 × log(M/M⊙)−0.05, we would expect a slightly elevated volumetric rate for redshifts beyond 3.2.
New compact hierarchical triple system candidates identified using Gaia DR3
Authors: Czavalinga D. R. , Mitnyan T. , Rappaport S. A. , Borkovits T. , Gagliano R. , Omohundro M. , Kristiansen M. H. K. , Pál A. 
Published: January 2023

Aims. We introduce a novel way to identify new compact hierarchical triple stars by exploiting the huge potential of Gaia DR3 and also its future data releases. We aim to increase the current number of compact hierarchical triple systems significantly.
Methods. We used several eclipsing binary catalogs from different sky surveys that list a total of more than 1 million targets to search for Gaia DR3 non-single-star orbital solutions with periods substantially longer than the eclipsing periods of the binaries. Those solutions in most cases are likely to belong to outer orbits of tertiary stars in those systems. We also attempted to validate some of our best-suited candidates using TESS eclipse timing variations.
Results. We find 403 objects with suitable Gaia orbital solutions of which 27 are already known triple systems, leaving 376 newly identified hierarchical triple system candidates in our sample. We find the cumulative probability distribution of the outer orbit eccentricities to be very similar to those found in earlier studies based on observations of the Kepler and OGLE missions. We find measurable nonlinear eclipse timing variations or third-body eclipses in the TESS data for 192 objects which we also consider to be confirmed candidates. Of these, we construct analytical light-travel time effect models for the eclipse timing variations of 22 objects with wellsampled TESS observations. We compare the outer orbital parameters from our solutions with those from the Gaia solutions and find that the most reliable orbital parameter is the orbital period, while the values of the other parameters should be used with caution.
The intense production of silicates during the final AGB phases of intermediate mass stars
Authors: Marini E. , Dell’Agli F. , Kamath D. , Ventura P. , Mattsson L. , Marchetti T. , García-Hernández D. A. , Carini R. , Fabrizio M. , Tosi S. 
Published: January 2023

Context. The formation of silicates in circumstellar envelopes of stars evolving through the asymptotic giant branch (AGB) is still highly debated given the uncertainties affecting stellar evolution modelling, the description of the dust formation process, and the capability of silicate grains to accelerate stellar outflows via radiation pressure.
Aims. We study the formation of dust in the winds of intermediate mass (M ≥ 4 M⊙) stars of solar metallicity while evolving through the AGB phase. We tested the different treatments of the mass-loss mechanism by this class of stars, with the aim of assessing their contribution to the general enrichment of silicates of the interstellar medium of galaxies and, on more general grounds, to the silicates budget of the Universe.
Methods. We consider a sub-sample of AGB stars, whose spectral energy distribution (SED) is characterised by deep absorption features at 10 μm and 18 μm, which can be regarded as the class of stars providing the most relevant contribution to the silicates’ production across the Universe. Results from stellar evolution and dust formation modelling were used to fit the observed SED and to reproduce, at the same time, the detected pulsation periods and the derived surface chemical composition. This analysis leads to the derivation of tight constraints on the silicates’ production rates experienced by these sources during the final AGB stages.
Results. Two out of the four sources investigated are interpreted as stars currently undergoing hot bottom burning (HBB), evolving through phases close to the stage when the mass-loss rate is largest. The remaining two stars are likely evolving through the very final AGB phases, after HBB was turned off by the gradual consumption of the convective mantle. Mass-loss rates of the order of 1 × 10−4 M⊙ yr−1 to 2 × 10−4 M⊙ yr−1 are required when looking for consistency with the observational evidence. These results indicate the need for a revision of the silicate yields by intermediate mass stars, which are found to be ∼3 times higher than previously determined.
Tonus et culture, de la mémoire corporelle à la transparence corporelle Une lecture transculturelle de la psychomotricité
Authors: Housseini-Houy Sabine , Camara Hawa , Moro Marie-Rose 
Published: January 2023

La culture est une réalité collective qui se transmet de génération en génération à travers l’éducation, nous indique M. Mead (1963). Nous développerons l’idée que le dialogue tonico-émotionnel de J. De Ajuriaguerra cher aux Psychomotriciens est un dialogue de transmission culturelle. Le dialogue tonico-émotionnel et les soins de maternage sont les supports de cette enculturation du corps maternant au corps du nouveau-né, et cela à leur insu. Notre approche théorique déroulera 3 temps forts de la régulation tonique et émotionnelle; le tonus sensoriel intra-utérin, le tonus gestuel accueilli par son berceau culturel, les effets de transparence psychique, corporelle et culturelle du dialogue tonico-émotionnel. Nous verrons comment cette enculturation s’inscrit et se transmet dans la construction et la remémoration du corps en relation.
L’histoire de Mme R et de son bébé, reçus dans notre unité de Périnatalité, viendra soutenir cette lecture psychomotrice et transculturelle. Mme R venue en France alors qu’elle était une jeune enfant n’a pu se soutenir du processus de transparence corporelle dans sa rencontre à son bébé. Nous développerons l’hypothèse que cette migration précoce a eu un effet sur la construction de sa mémoire corporelle et, a été un empêchement à la mise en route du processus de transparence corporelle ainsi que culturelle. Nous tenterons alors d’inventer et d’adapter un cadre de soins, pour cette dyade, au travers d’une expérience de suivi à domicile et au sein d’une unité ambulatoire de périnatalité.
Aprotinin does not Impair Vascular Function in Patients Undergoing Coronary Artery Bypass Graft Surgery
Authors: Tolkmitt Josephine , Brendel Heike , Zatschler Birgit , Brose Stefan , Brunssen Coy , Kopaliani Irakli , Deussen Andreas , Matschke Klaus , Morawietz Henning 
Published: January 2023

AbstractBleeding is a major complication in coronary artery bypass graft surgery. Antifibrinolytic agents like serine protease inhibitor aprotinin can decrease postoperative bleeding and complications of cardiac surgery. However, the effects of aprotinin on vascular function are not completely elucidated. We compared the ex vivo vascular function of left internal mammary arteries from patients undergoing coronary artery bypass graft surgery with and without intraoperative application of aprotinin using a Mulvany Myograph. Human internal mammary arteries were treated with aprotinin ex vivo and tested for changes in vascular function. We analyzed the impact of aprotinin on vascular function in rat aortic rings. Finally, impact of aprotinin on expression and activity of endothelial nitric oxide synthase was tested in human endothelial cells. Intraoperative application of aprotinin did not impair ex vivo vascular function of internal mammary arteries of patients undergoing coronary artery bypass graft surgery. Endothelium-dependent and -independent relaxations were not different in patients with or without aprotinin after nitric oxide synthase blockade. A maximum vasorelaxation of 94.5%±11.4vs. 96.1%±5.5% indicated a similar vascular smooth muscle function in both patient groups (n=13 each). Long-term application of aprotinin under physiological condition preserved vascular function of the rat aorta. In vitro application of increasing concentrations of aprotinin on human endothelial cells resulted in a similar expression and activity of endothelial nitric oxide synthase. In conclusion, intraoperative and ex vivo application of aprotinin does not impair the endothelial function in human internal mammary arteries and experimental models.
Encountering Peritoneo-Cutaneous Perforators in Microsurgical DIEP Flap Breast Reconstruction
Authors: Loi Duncan , Easton Justin L. , Rozen Warren M. 
Published: January 2023

AbstractThe vascular anatomy of the deep inferior epigastric artery perforator (DIEP) flap has been well studied in the planning for autologous breast reconstruction. Preoperative imaging with computed tomography angiography (CTA) provides accurate assessment of this vascular anatomy, which varies widely across patients. Several papers to date have described their encounter with an anomalous “epiperitoneal” or “peritoneo-cutaneous” perforator during flap harvest, a perforator that pierces the posterior rectus sheath from a peritoneal origin, to traverse rectus abdominis and supply the DIEP flap integument. In the course of over 3,000 CTA assessments of the vascular anatomy of the abdominal wall, we have encountered dominant peritoneo-cutaneous perforators in 1% of cases, and smaller perforators seen in many more cases, approaching 5% of cases. With increasing sensitivity of imaging, we also describe a unique case of multiple large bilateral peritoneo-cutaneous perforators, and present these findings in the context of DIEP flap harvest. It is critical to recognize these peritoneo-cutaneous perforators preoperatively to avoid mistaking them for a DIEP during the raising of a DIEP flap. The routine use of preoperative CTA enables the safe identification of individual vascular anatomy, including significant peritoneo-cutaneous perforators.
Advances in Enantioconvergent Transition-Metal-Catalyzed Cross-Coupling Reactions of Racemic α-Silyl and α-Boryl Reagents
Authors: Oestreich Martin , Kranidiotis-Hisatomi Nektarios 
Published: January 2023

AbstractEnantioconvergent transition-metal-catalyzed cross-coupling reactions of racemic α-silyl and α-boryl reagents represent one of the key tools to afford highly enantioenriched α-chiral silanes and boranes. The approach traces back the use of α-silyl nucleophiles, employing palladium precatalysts. More recent work makes use of α-silyl and α-boryl electrophiles under nickel and copper catalysis. The limits of this field have been significantly extended by the design and development of numerous chiral ligands. In this short review, the progress made in this rapidly evolving field is summarized.1	Introduction2	α-Silyl Nucleophiles and Electrophiles2.1	Palladium Catalysis2.2	Nickel Catalysis2.3	Copper Catalysis3	α-Boryl Electrophiles3.1	Nickel Catalysis4	Summary and Outlook
Extracorporeal Membrane Oxygenation and Hemolytic Uremic Syndrome in Children: Outcome Review of a Multicenter National Database
Authors: Liboiron Mireille , Malone Matthew P. , Brown Clare C. , Prodhan Parthak 
Published: January 2023

AbstractHemolytic uremic syndrome (HUS) is a triad of hemolytic anemia, thrombocytopenia, and acute renal failure. In critically ill children with HUS, extrarenal manifestations may require intensive care unit admission and extracorporeal membrane oxygenation (ECMO) support. Outcomes specific to HUS and ECMO in children have not been well investigated. The primary aim of this project was to query a multicenter database to identify risk factors associated with mortality in HUS patients supported on ECMO. A secondary aim was to identify factors associated with ECMO utilization in children with HUS. Utilizing the Pediatric Health Information System database (January 2004 and September 2018), this retrospective, multicenter cohort study identified the index HUS hospitalization among children aged 0 to 18 years. Univariate analysis was used to compare demographics, clinical characteristics, and procedures to identify risk factors associated with adverse outcomes. Among 4,144 subjects, 37 were supported on ECMO. Survival for those on ECMO support was 54%. Among nonsurvivors, 59% of deaths occurred within 14 days of hospitalization. The mean hospital LOS was 15.9 days in nonsurvivors versus 53.9 days for survivors (p < 0.001). When comparing subjects supported on ECMO to those who were not, patients with ECMO support had statistically longer hospital LOS and higher rates of extrarenal involvement (p < 0.001). This study found a mortality rate of 46% among HUS patients requiring ECMO. The investigated clinical risk factors were not associated with mortality among the ECMO population. The study identifies risk factors associated with ECMO utilization in children with HUS.
Evaluation of the Masking Effect of Different Glass Ionomer Restorations following Silver Diamine fluoride and Potassium Iodide Application: An In Vitro Study
Authors: Raafat Rasha , Abuzaid Mohamed , Abd ElAziz Rawda Hesham 
Published: January 2023

Abstract
Objectives This is an in vitro study that aimed to evaluate the ability of different glass ionomer restorations to mask the discoloration produced following silver diamine fluoride (SDF) only and after potassium iodide (KI) application.
Materials and Methods Thirty-six extracted human adult posterior teeth were collected. Box-shaped cavities (4 × 2 × 2 mm3) were prepared along the cementoenamel junction. Specimens were randomly divided into two major groups according to the materials applied under the restorations group (A) 38% silver diamine fluoride (SDF) followed by immediate application of potassium iodide (KI), group (B) 38% silver diamine fluoride (SDF) only. Each group was further subdivided according to the restorative material applied as follows (n = 6): subgroup (I) zirconia reinforced glass ionomer, subgroup (II) resin-modified glass ionomer restoration, and subgroup (III) high viscous glass ionomer restoration. Color assessment of all specimens was performed using a reflective spectrophotometer. Specimens' color was assessed color of normal dentin then assessed immediately after application of SDF (group A) and after application SDF + KI (group B) with the respective restorative material used.
Statistical Analysis Data showed parametric distribution and variance homogeneity and were analyzed using one-way analysis of variance followed by Tukey's post hoc test.
Results Intergroup comparisons showed that for SDF and SDF + KI samples, there was a significant difference between the different restorative materials (p < 0.001). For glass ionomer, SDF samples had significantly higher color change value than SDF + KI (p < 0.001), while for RMGI and zirconia reinforced glass ionomer, SDF + KI samples had significantly higher value (p < 0.001) although zirconia reinforced glass ionomer showed the least color change following SDF (6.00 ± 2.74).
Conclusion Within the limitations of this study, we could conclude that using zirconia reinforced glass ionomer could have a good masking effect on discoloration produced by SDF. While the resin-modified glass ionomer restoration showed more discoloration and darkening effect even after using of KI. Also, using KI in combination with SDF had a good masking effect on discoloration that produced by SDF.