bluuebunny/crossref_metadata_2025_split huggingface dataset:
Narrative Review of Anomalous Origin of Coronary Arteries: Pathophysiology,
Management, and Treatment
Authors: Kanagala Sai Gautham , Gupta Vasu , Dunn Garrett V , Kaur Harmanjit , Zieneddine Farid , Jain Rohit , Garg Nikita 
Published: June 2023

Abstract:
Coronary artery anomalies (CAA) are a diverse group of congenital anomalies and are
the second most common cause of sudden cardiac death in the young population after Hypertrophic
Cardiomyopathy (HCM). Symptoms range from chest pain, syncope, or sudden cardiac arrest to
completely asymptomatic. The prevalence of congenital coronary artery anomalies in the general
population is estimated to be between 1% and 2%. CAA often gets underdiagnosed due to the lack
of knowledge of the disease process. Approximately 5% of patients with acute myocardial infarction
do not have atherosclerotic coronary artery disease or luminal narrowing due to other causes.
Congenital coronary artery anomalies account for 50-60% of this 5% of patients. Most patients are
asymptomatic for most of their lives, and chest pain is the most common symptom in symptomatic
patients when referred for coronary angiography, typically when the diagnosis is typically made.
The malignant coronary artery is a rare presentation of a coronary anomaly when associated with
atherosclerotic coronary artery disease or valvular heart disease. Patients with symptoms of an abnormal
coronary artery origin will receive medical treatment/observation, exercise restriction, coronary
angioplasty with stent deployment, or surgical repair.
MDM2-mediated Inhibitory Effect of Arsenic Trioxide on Small Cell Lung Cancer
Cell Line by Degrading Mutant p53
Authors: Wang Yu-Sheng , Yin Ji-Zhong , Shi Xiao-Qian , Zhao Xue-Wei , Li Bing , Yang Meng-Hang 
Published: June 2023

Introduction:
Small cell lung cancer (SCLC) is featured by a high TP53 mutant rate. Our previous research
found that arsenic trioxide (As2O3) could significantly inhibit the growth and metastasis of SCLC. Studies have shown
that the degradation of mutant p53 mediated by murine double minute 2 (MDM2) can be induced by As2O3, which
probably contributes to the inhibition of SCLC, but the detailed mechanism is still unclear. We aimed to testify that
As2O3 can inhibit the growth of SCLC cells by degrading mutant p53 protein via binding to MDM2.

Methods:
CCK-8 assay, cell cycle analysis, and western blot of apoptosis markers were used to evaluate the inhibitory
effect of As2O3 on NCI-H446 cells (containing mutant p53) and NCI-H1299 cells (p53 null). The effects of As2O3 on
p53 and its downstream proteins were identified by western blot using mut-p53-knockdown and overexpressed cell
models. MDM2-knockdown cell models were constructed, and western blot, co-IP of mut-p53, and ubiquitin were
carried out to explore the mediating effect of MDM2 in As2O3 induced mut-p53 degradation.

Results:
As2O3 inhibited proliferation and induced cell cycle arrest and apoptosis of SCLC cells in a dose- and timedependent
manner. After mut-p53 knockdown or overexpressed, the inhibitory effect of As2O3 was dampened or enhanced.
Additionally, As2O3-induced mut-p53 ubiquitination was significantly weakened after MDM2 knockdown.

Conclusion:
As2O3 could inhibit SCLC cells by inhibiting proliferation and inducing cell cycle arrest and apoptosis.
These inhibitory effects were achieved at least in part by upregulating MDM2, which, in turn, promotes ubiquitination
and degradation of mut-p53.
Phytosomal Drug Delivery System: A Detailed Study
Authors: Kamireddy Srikala , Sangeetha S. , Kosanam Sreya 
Published: June 2023

Abstract:Nature contains a diverse range of phytoconstituents that possess several pharmacological properties. However, the effectiveness of herbal formulations is limited due to the poor bioavailability of phytoconstituents, which makes it difficult for them to pass through the cell membrane. Phytosomes are a modern type of herbal formulation that comprises therapeutically active phytoconstituents extracted from medicinal plants and enclosed by phospholipids. By combining phytoconstituents with phospholipids, phytosomes are able to enhance bioavailability and reduce side effects. Various techniques such as solvent evaporation, rotatory evaporation, anti-solvent precipitation, freeze-drying, and solvent ether injection can be used to prepare phytosomes. Phytosomes can be evaluated using methods such as UV-Spectra, DSC, drug entrapment and loading capacity, surface tension activity measurement, and in-vitro/in-vivo studies. This review discusses different methods for preparing phytosomal formulations and their advantages, which have been found to significantly improve the bioavailability of phytoconstituents. Phytosomes have high entrapment efficiency and do not compromise the safety of nutrients. By utilizing phytosomal drug delivery, issues associated with conventional drug delivery may be overcome. Therefore, it is important to combine Indian Ayurvedic medicine with novel drug delivery systems to improve drug delivery technologies.
Frequency of Prenatal Care Visits: Protocol to Develop a Core Outcome Set for Prenatal Care Schedules
Authors: Turrentine Mark , Nguyen Buu-Hac , Choby Beth , Kendig Susan , King Tekoa L , Kotelchuck Milton , Moore Simas Tiffany A , Srinivas Sindhu K , Zahn Christopher M , Peahl Alex Friedman 
Published: June 2023

Background
Prenatal care, one of the most common preventive care services in the United States, endeavors to improve pregnancy outcomes through evidence-based screenings and interventions. Despite the prevalence of prenatal care and its importance to maternal and infant health, there are several debates about the best methods of prenatal care delivery, including the most appropriate schedule frequency and content of prenatal visits. Current US national guidelines recommend that low-risk individuals receive a standard schedule of 12 to 14 in-office visits, a care delivery model that has remained unchanged for almost a century.

Objective
In early 2020, to mitigate individuals’ exposure to the SARS-CoV-2 virus, prenatal care providers implemented new paradigms that altered the schedule frequency, interval, and modality (eg, telemedicine) of how prenatal care services were offered. In this paper, we describe the development of a core outcome set (COS) that can be used to evaluate the effect of the frequency of prenatal care schedules on maternal and infant outcomes.

Methods
We will systematically review the literature to identify previously reported outcomes important to individuals who receive prenatal care and the people who care for them. Stakeholders with expertise in prenatal care delivery (ie, patients or family members, health care providers, and public health professionals and policy makers) will rate the importance of identified outcomes in a web-based survey using a 3-round Delphi process. A digital consensus meeting will be held for a group of stakeholder representatives to discuss and vote on the outcomes to include in the final COS.

Results
The Delphi survey was initiated in July 2022 with invited 71 stakeholders. A digital consensus conference was conducted on October 11, 2022. Data are currently under analysis with plans to submit them in a subsequent manuscript.

Conclusions
More research about the optimal schedule frequency and modality for prenatal care delivery is needed. Standardizing outcomes that are measured and reported in evaluations of the recommended prenatal care schedules will assist evidence synthesis and results reported in systematic reviews and meta-analyses. Overall, this COS will expand the consistency and patient-centeredness of reported outcomes for various prenatal care delivery schedules and modalities, hopefully improving the overall efficacy of recommended care delivery for pregnant people and their families.

International Registered Report Identifier (IRRID)
DERR1-10.2196/43962
Perspectives of Rehabilitation Professionals on Implementing a Validated Home Telerehabilitation Intervention for Older Adults in Geriatric Rehabilitation: Multisite Focus Group Study
Authors: Pol Margriet , Qadeer Amarzish , van Hartingsveldt Margo , Choukou Mohamed-Amine 
Published: June 2023

Background
Owing to demographic trends and increasing health care costs, quick discharge with geriatric rehabilitation at home is advised and recommended for older adults. Telerehabilitation has been identiﬁed as a promising tool to support rehabilitation at home. However, there is insufficient knowledge about how to implement a validated home telerehabilitation system in other contexts. One of the major challenges for rehabilitation professionals is transitioning to a blended work process in which human coaching is supplemented via digital care.

Objective
The study aimed to gain an in-depth understanding of the factors that influence the implementation of an evidence-based sensor monitoring intervention (SMI) for older adults by analyzing the perspectives of rehabilitation professionals working in 2 different health ecosystems and mapping SMI barriers and facilitators.

Methods
We adopted a qualitative study design to conduct 2 focus groups, 1 in person in the Netherlands during winter of 2017 and 1 on the web via Zoom (Zoom Video Communications; owing to the COVID-19 pandemic) in Canada during winter of 2022, to explore rehabilitation providers’ perspectives about implementing SMI. Qualitative data obtained were analyzed using thematic analysis. Participants were a group of rehabilitation professionals in the Netherlands who have previously worked with the SMI and a group of rehabilitation professionals in the province of Manitoba (Canada) who have not previously worked with the SMI but who were introduced to the intervention through a 30-minute web-based presentation before the focus group.

Results
The participants expressed different characteristics of the telerehabilitation intervention that contributed to making the intervention successful for at-home rehabilitation: focus on future participation goals, technology support provides the rehabilitation professionals with objective and additional insight into the daily functioning of the older adults at home, SMI can be used as a goal-setting tool, and SMI deepens their contact with older adults. The analysis showed facilitators of and barriers to the implementation of the telerehabilitation intervention. These included personal or client-related, therapist-related, and technology-related aspects.

Conclusions
Rehabilitation professionals believed that telerehabilitation could be suitable for monitoring and supporting older adults’ rehabilitation at home. To better guide the implementation of telerehabilitation in the daily practice of rehabilitation professionals, the following steps are needed: ensuring that technology is feasible for communities with limited digital health literacy and cognitive impairments, developing instruction tools and guidelines, and training and coaching of rehabilitation professionals.
Supporting Adolescents With HIV in South Africa Through an Adherence-Supporting App: Mixed Methods Beta-Testing Study
Authors: Mulawa Marta I , Mtukushe Bulelwa , Knippler Elizabeth T , Matiwane Mluleki , Al-Mujtaba Maryam , Muessig Kathryn E , Hoare Jacqueline , Hightow-Weidman Lisa B 
Published: June 2023

Background
Novel smartphone app–delivered interventions have the potential to improve HIV treatment adherence among adolescents with HIV, although such interventions are limited. Our team has developed Masakhane Siphucule Impilo Yethu (MASI; Xhosa for “Let's empower each other and improve our health”), a smartphone app–delivered intervention to improve treatment adherence among adolescents with HIV in South Africa. MASI was adapted to the South African cultural context using the HealthMpowerment platform, an evidence-based digital health intervention developed for and with youth in the United States.

Objective
We conducted this beta-testing study to (1) explore the initial usability of MASI, (2) examine engagement and experiences using MASI features, and (3) inform refinements to the app and intervention implementation plan prior to a subsequent pilot randomized controlled trial (RCT).

Methods
This study was conducted from August 2021 to December 2021 in Cape Town, South Africa. Beta-testing participants received access to MASI for 3 weeks. A mixed methods approach was used, with brief questionnaires and semistructured in-depth interviews conducted prior to app installation and after 1 week to 2 weeks of app testing. Engagement with MASI was measured through analysis of back-end app paradata, and follow-up in-depth interview guides were tailored to each participant based on their app use.

Results
Participants in the beta-testing study (6 male participants, 6 female participants; ages 16-19 years) collectively spent 4.3 hours in MASI, averaging 21.4 minutes per participant over the 3-week period (range 1-51.8 minutes). Participants logged into MASI an average of 24.1 (range 10-75) times during the study period. The mean System Usability Scale score was 69.5 (SD 18), which is considered slightly above average for digital health apps. Thematic analysis of qualitative results revealed generally positive experiences across MASI features, although opportunities to refine the app and intervention delivery were identified.

Conclusions
Initial usability of MASI was high, and participants described having a generally positive experience across MASI features. Systematically analyzing paradata and using the interview findings to explore participant experiences allowed us to gain richer insights into patterns of participant engagement, enabling our team to further enhance MASI. The results from this study led to a few technological refinements to improve the user experience. Enhancements were also made to the intervention implementation plan in preparation for a pilot RCT. Lessons learned from the conduct of this beta-testing study may inform the development, implementation, and evaluation of similar app-delivered interventions in the future.
<strong>Insulin Sensitivity and Beta-Cell Function During Early and Late Pregnancy in Women with and without Gestational Diabetes Mellitus</strong>
Authors: Mittendorfer Bettina , W. Patterson Bruce , Haire-Joshu Debra , G. Cahill Alison , Todd Cade W. , I. Stein Richard , Klein Samuel 
Published: June 2023

<p> </p>
<p><strong>Objective:</strong> To evaluate the metabolic alterations associated with gestational diabetes mellitus (GDM) in women with overweight/obesity.</p>
<p><strong>Methods:</strong> We compared fasting and postprandial plasma glucose and free fatty acid (FFA) concentrations, insulin sensitivity (Matsuda index), and β-cell function (β-cell responsiveness to glucose) by using a frequently-sampled oral glucose tolerance test (OGTT) at 15 and 35 weeks’ gestation in women with overweight/obesity who had GDM (n=29) or did not have GDM (n=164) at 35 weeks.</p>
<p><strong>Results:</strong> At 15 weeks, insulin sensitivity and β-cell function were lower and fasting, 1-hour and total area-under-the-curve plasma glucose during the OGTT were higher (all <em>P</em><0.05) in the GDM than in the No-GDM group. At 35 compared with 15 weeks, insulin sensitivity decreased, β-cell function increased, and postprandial suppression of plasma FFA was blunted in both the GDM and No-GDM groups, but the decrease in insulin sensitivity and the increase in postprandial FFA concentration were greater and the increase in β-cell function was less (all <em>P</em>≤0.05) in the GDM than in the No-GDM group. A receiver-operating-curve analysis showed both fasting plasma glucose and 1-hour OGTT glucose at 15 weeks are predictors of GDM, but the predictive power was <30%.</p>
<p><strong>Conclusion:</strong> Women with overweight/obesity and GDM, compared to those without GDM, have worse insulin sensitivity and β-cell function early during pregnancy and a greater subsequent decline in insulin sensitivity and blunted increase in β-cell function. Increased fasting and 1-hour OGTT plasma glucose early during pregnancy are markers of increased GDM risk, albeit with weak predictive power.<br>
</p>
Pengaruh Pelatihan Four Corners Drill Dan Two Wheel Drill Terhadap Keterampilan Passing (Chest Pass) Pada Siswa Ekstrakurikuler Bola Basket SMA Negeri 1 Paciran
Authors: Pradyta Sunur Denta , Happy Kardiawan I Kadek , Budi Darmawan Gede Eka 
Published: June 2023

Penelitian ini bertujuan untuk mengetahui (1) pengaruh pelatihan four corners drill terhadap keterampilan passing (chest pass), (2) pengaruh pelatihan two wheel drill terhadap keterampilan passing (chest pass), dan (3) perbedaan pengaruh antara pelatihan four corners drill dan two wheel drill terhadap keterampilan passing (chest pass) pada siswa ekstrakurikuler bola basket SMA Negeri 1 Paciran. Subjek pada penelitian ini adalah siswa peserta ekstrakilikuler bola basket SMA Negeri 1 Paciran yang berjumlah 30 orang. Metode penelitian ini menggunakan rancangan the modified two grup pre-test – post-test design. Tes yang digunakan adalah tes keterampilan passing wall pass. Analisis data menggunakan perhitungan statistik uji-t (t-test) pada taraf signifikansi 5%. Hasil analisis data menunjukan (1) pelatihan four corners drill berpengaruh terhadap keterampilan passing (chest pass) dengan hasil thitung 3,982 > ttabel 2,048 dan persentase kenaikan sebesar 69,3%, (2) pelatihan two wheel drill berpengaruh terhadap keterampilan passing (chest pass) pada siswa ekstrakurikuler bola basket SMA Negeri 1 Paciran. Dengan hasil thitung 4,496 > ttabel 2,048 dan persentase kenaikan sebesar 78,4%, (3) terdapat perbedaan pengaruh antara pelatihan four corners drill dan two wheel drill terhadap keterampilan passing (chest pass) dengan hasil thitung 3,147 > ttabel 2,048 dan persentase kenaikan sebesar 9,1% dimana pelatihan Two wheel drill lebih berpengaruh dari pada pelatihan Four corners drill dikarenakan walaupun kedua pelatihan tersebut sama-sama dimaksudkan untuk meningkatkan keterampilan passing pada pemain bola basket, yang membedakan dua variabel dalam penelitian ini adalah pelaksanaannya
Hubungan Tinggi Badan, Power Otot Tungkai Dan Power Otot Lengan Terhadap Kemampuan Smash Pada Club Bola Voli Citroen Pedawa Tahun 2020
Authors: Ramawan Kadek , Hidayat Syarif , Budi Darmawan Gede Eka 
Published: June 2023

Penelitian ini bertujuan untuk mengetahui hubungan antara tinggi badan, power otot tungkai dan power otot lengan terhadap kemampuan smash. Penelitian ini menggunakan metode korelasi. Subjek penelitian 20 orang. Analisis data menggunakan uji korelasi dengan taraf signifikansi r > r tabel. Hasil penelitian adalah sebagai berikut (1) terdapat hubungan antara tinggi badan terhadap kemampuan smash dengan hasil r = 611 > r tabel = 0,444, (2) terdapat hubungan antara power otot tungkai terhadap kemampuan smash dengan hasil r = 0,634 > r tabel = 0,444, (3) terdapat hubungan antara power otot lengan terhadap kemampuan smash dengan hasil r = 817 > r tabel = 0,444, dan (4) terdapat hubungan antara tinggi badan, power otot tungkai dan power otot lengan terhadap kemampuan smash dengan hasil r = 842 > r tabel = 0,444.
Pengaruh Pelatihan Interval Anaerob Jarak 60-100 Meter Dan Jarak 110-150 Meter Terhadap Kecepatan Lari 100 Meter Pada Siswa Putra Kelas X Sma Negeri 1 Kubu Karangasem
Authors: Wiwin Ariningsih Ni Komang , Suratmin Suratmin , Chandra Adinata Kusuma Ketut 
Published: June 2023

Penelitian ini bertujuan untuk mengetahui pengaruh pelatihan interval anaerob jarak 60-100 dan interval anaerob jarak 110-150 terhadap kecepatan lari 100 meter. Metode penelitian yang digunakan adalah metode eksperimen. Rancangan penelitian yang digunakan the modified pre-test – post-test group design. Subyek penelitian ini berjumlah 30 orang siswa berjenis kelamin putra. Tes yang digunakan lari 100 meter. Analisis data menggunakan perhitungan statistik uji-t taraf signifikansi 5%. Hasil analisis data menunjukkan (1)pelatihan interval anaerob jarak 60-100, dengan hasil thitung sebesar 5,701>ttabel=2,145, (2)pelatihan interval anaerob jarak 110-150, dengan hasil thitung= 5,528 > ttabel=2,145, dan (3)perbedaan pengaruh antara pelatihan interval anaerob jarak 60-100 dan jarak 110-150, dengan hasil thitung=1.323<ttabel=2,048. Sehingga disimpulkan bahwa (1)terdapat pengaruh pelatihan interval anaerob jarak 60-100 signifikan, (2)terdapat pengaruh pelatihan interval anaerob jarak 110-150, dan (3)tidak terdapat perbedaan pengaruh pelatihan interval anaerob jarak 60-100 dan jarak 110-150 terhadap kecepatan lari 100 meter, dengan hasil peningkatan sama baik meningkatkan kecepatan lari.
La puesta en escena de lo que llamamos latinoamericano. Una década de reflexión en la revista Arte en Colombia (1978-1990)
Authors: Muñoz Porqué Bárbara 
Published: June 2023

In this article I examine how the relationship between cultural modernity and the artistic avant-garde was configured during the transition from the end of the 19th century to the second half of the 20th century in Latin America. An examination of a set of essays that address the idea of Latin American identity reveals how artists and theorists have tried, in different historical periods, to identify the nuances of critical thinking and art production in the region. In a second section, with the aim of delving deeper into the definition of what is Latin American, I carry out a rereading of a series of articles published between 1978 and 1990 in Arte en Colombia magazine that address both the composition of institutional collections and the design of exhibitions, mainly in the United States and Europe. With this methodology I delineate how certain museum narratives deploy experiences of identity that perpetuate —occasionally questionable— understandings of Latin American art. Through their criticism, the writers selected for this analysis react to outdated policies of representation, allowing us to re-elaborate possible ways of retelling artistic reality from the standpoint of Latin America.
Formulasi dan Uji Aktivitas Antioksidan Sediaan Face Mist Ekstrak Etanol Kulit Apel Hijau (Pyrus malus L.) dengan Metode DPPH
Authors: Asjur Asti Vebriyanti , Santi Elvira , Musdar Tamzil Azizi , Saputro Syaifullah , Rahman Rosmiati Anggraini 
Published: June 2023

Kulit apel hijau (Pyrus malus L.) merupakan buah yang kaya akan kandungan gizi, terutama bahan kimia antioksidan yang bermanfaat bagi tubuh manusia. Penelitian ini bertujuan untuk mengetahui ekstrak etanol kulit apel hijau (Pyrus malus L.) dapat dibuat dalam sediaan face mist dan mengetahui nilai IC50 sediaan face mist dari ekstrak etanol kulit apel hijau (Pyrus malus L.) dapat memberikan aktivitas antioksidan. Penelitian ini menggunakan metode dan membuat sediaan face mist menggunakan variasi konsentrasi ekstrak pada formula 1 0,1%, formula 2 0,3% dan formula 3 0,5% dan menguji aktivitas antioksidan menggunakan metode DPPH. Ekstrak kulit apel hijau dapat dibuat sediaan face mist, berdasarkan hasil uji cycling test ketiga formula sediaan face mist ekstrak etanol kulit apel hijau (Pyrus malus L.) memiliki stabilitas fisik face mist yang baik. Hasil IC50 yang diperoleh berturut-turut terhadap formula 1 (0,1%), yaitu 18,83 ppm memiliki aktivitas antioksidan yang kuat, formula 2 (0,3%) yaitu 9,19 ppm memiliki nilai antioksidan yang sangat kuat, dan formula 3 (0,5%) yaitu 6,51 ppm memiliki nilai antioksidan yang sangat kuat dapat disimpulkan bahwa ekstrak kulit apel hijau (Pyrus malus L.) dapat diformulasi menjadi sediaan face mist stabil sebelum dan sesudah cycling test dan nilai IC50 formula 3 (0,5%) yaitu 6,51 ppm yang memiliki aktivitas antioksidan sangat kuat.