bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effectiveness of locally produced ready to use supplementary food on hemoglobin, anthropometrics, and plasma micronutrients concentrations of 6 to 23 months age children: a non-randomized community-based trial from Pakistan
Authors: Khan Aslam , Ul-Haq Zia , Fazid Sheraz , Fatima Sadia , Muhammad Nawshad , Ahmed Jawad , Manoharadas Salim , Safi Sher Zaman , Habib Ijaz , Garzon Cecilia , Ihtesham Yasir , Zahid Fareeda , Dad Fazal , Mahamadou Tanimoune , Lowe Nicola M. 
Published: July 2023

BackgroundMicronutrient deficiencies including vitamin A, vitamin D, and zinc are highly prevalent in children below 5 years of age in low and –middle-income countries. We aimed to evaluate the effectiveness of ready-to-use Lipid-based Nutrient Supplement—Medium Quantity (LNS-MQ) local name “Wawa-mum” on plasma micronutrient status, hemoglobin concentration and anthropometric measurements.MethodsA community-based non-randomized trial was conducted in the Kurram district of Khyber Pakhtunkhwa from January 2018 to June 2019. A total of 110 children aged 6 to 23 months old were recruited and allocated to the intervention and control arm of the study. A total of 57 children in the intervention arm received a daily ration of 50 g of Wawa-mum, for one year. To assess the impact of the intervention on primary outcome measures, i.e., serum vitamin A, D concentration, plasma zinc, and hemoglobin concentration. Blood samples were collected at baseline and after one year following the intervention. The vitamins concentration in serum were assessed using Enzyme-Linked Immunosorbent Assay (ELISA) and plasma zinc by atomic absorption spectrometry. The hemoglobin concentration was measured by an automated hematology analyzer. A 24-h dietary recall interview was used to assess the nutrient intake adequacy. Multivariate Linear regression models were used to analyze the outcomes while controlling for potential confounders.ResultsIn the intervention arm, children had on average 6.2 μg/dL (95% CI 3.0–9.3, value of p&lt;0.001) increase in the serum vitamin A concentration, 8.1 ng/mL (95% CI 1.3–14.9, value of p 0.02) increase in serum vitamin D concentration and 49.0 μg/dL (95% CI 33.5–64.5, value of p&lt;0.001) increase in the plasma zinc concentration, and 2.7 g/dL (95% CI 2.0–3.3, value of p&lt;0.001) increase in hemoglobin concentration while adjusted for covariates. An addition, length-for-age z-score (LAZ), weight-for-length z-score (WLZ), weight-for-age z-score (WAZ), and prevalence of undernutrition including stunting, wasting, and underweight were calculated as a secondary outcome to investigate the impact of micronutrients on growth parameters, that has been improved significantly after receiving the Wawa-mum.ConclusionWawa-mum (LNS-MQ) is an effective intervention to improve the micronutrient status, hemoglobin concentration, and growth parameters in 6 to 23 months children, which can be scaled up in the existing health system to address the alarming rates of under nutrition in Pakistan and other developing countries.Clinical trial registrationhttps://doi.org/10.1186/ISRCTN94319790, ISRCTN94319790.
Blau syndrome with hypertension and hepatic granulomas: a case report and literature review
Authors: Yao Fangling , Tan Bei , Wu Di , Shen Min 
Published: July 2023

BackgroundBlau syndrome (BS) is a monogenic disorder caused by NOD2 gene variants characterized by the triad of granulomatous polyarthritis, rash, and uveitis. Atypical symptoms were recognized in one-third to one-half of individuals with BS. This study aims to describe the clinical features of BS patients with hypertension and digestive system involvement.MethodsThe complete clinical data of a BS patient complicated with hypertension and hepatic granulomas were collected and documented. We also performed a literature search to find all reported cases of BS with hypertension and digestive system involvement.ResultsWe reported the case of a 19-year-old man who presented with early onset symmetric polyarthritis and hypertension at age 5 and hepatic granulomas and cirrhosis at age 19. He was diagnosed with BS by the finding of a variant of the NOD2 gene (R334W). Through the literature review, 24 patients with BS were found who were reported to have hypertension, and 38 patients were found who had different digestive system manifestations such as hepatic granulomas, hepatosplenomegaly, diverticulitis, and intestinal granuloma. Among the 38 BS patients with digestive system involvement, 14 had hepatic granulomas proven by liver biopsy.ConclusionsHypertension and digestive system involvement are rare manifestations of BS. Clinicians, especially rheumatologists, must be aware of atypical symptoms of BS.
Differences in the pharmacokinetics and steady-state blood concentrations of orally administered lenvatinib in adult and juvenile rats
Authors: Du Xiaoyue , Cai Hongxin , Jin Nan , Wu Zhiguo , Wang Lele , Wang Zeyu , Xie Baogang 
Published: July 2023

Objective: The aim of this study was to compare the pharmacokinetics and steady-state serum concentrations of lenvatinib in adult and juvenile rats.Experimental study: An ultra-performance liquid chromatography-mass spectrometry (UPLC-MS) method was developed to quantify lenvatinib in the serum and liver of rats. Six juvenile and six adult rats in each group were orally administered with a single dose of 7.0 mg/kg lenvatinib suspension for pharmacokinetics. Another 12 juvenile and adult rats were subjected to oral gavage with 7.0 mg/kg lenvatinib once daily for 5 days. Biofluild samples were pre-treated by protein precipitation and sorafenib was used as the internal standard for UPLC-MS analysis. The pharmacokinetic parameters were estimated by compartment and statistical model. The mRNA expression of CYP3A2 and SLC22A1 in liver of adult and juvenile rats was measured by real-time fluorescence quantitative PCR (RT-qPCR).Results: The UPLC-MS method met the requirements for quantitative analysis of lenvatinib in serum and liver. The pharmacokinetic results showed that the mean retention time (MRT(0-∞)) was 19.64 ± 7.64 h and 126.38 ± 130.18 h, with AUC(0-∞) values of 3.97 ± 0.73 μg‧mL-1 h and 5.95 ± 2.27 μg mL-1 h in adult and juvenile rats, respectively. When comparing adult rats (0.35 ± 0.15 μg/mL) to juvenile rats, no significant differences were observed in steady-state serum lenvatinib (0.32 ± 0.11 μg/mL), but a noteworthy decrease to one-third of steady-state liver lenvatinib was observed after multiple oral doses of lenvatinib in juvenile rats. Additional findings revealed that the mRNA expression of CYP3A2 and SLC22A1 was notably increased by 6.86 and 14.67 times, respectively, in juvenile rats compared to adult rats.Conclusion: Juvenile rats exhibit lower levels of lenvatinib in the liver’s steady-state, potentially due to the disparity in CYP3A2 mRNA expression. These results imply that the dosage of lenvatinib for pediatric patients may need to be augmented in order to attain the desired clinical outcome.
Research trends and hotspots on the links between caveolin and cancer: bibliometric and visual analysis from 2003 to 2022
Authors: Tan Yaqian , Song Qi 
Published: July 2023

Introduction: Extensive studies indicated that caveolin is a key regulator in multiple cellular processes. Recently, growing evidence demonstrated that caveolin is critically involved in tumor progression. Since no relevant bibliometric study has been published, we performed a bibliometric and visual analysis to depict the knowledge framework of research related to the involvement of caveolin in cancer. Methods: Relevant studies published in English during 2003–2022 were obtained from the Web of Science Core Collection database. Three programs (VOSviewer, CiteSpace, and R-bibliometrix) and the website of bibliometrics (http://bibliometric.com/) were applied to construct networks based on the analysis of countries, institutions, authors, journals, references, and keywords.Results: A total of 2,463 documents were extracted and identified. The United States had the greatest number of publications and total citations, and Thomas Jefferson University was the most productive institution. Michael P. Lisanti was the most influential scholar in this research domain. Cell Cycle was the journal with the most publications on this subject. The most local-cited document was the article titled “Caveolin-1 in oncogenic transformation, cancer, and metastasis.” A comprehensive analysis has been conducted based on keywords and cited references. Initially, the research frontiers were predominantly “signal transduction”, “human breast cancer,” “oncogenically transformed cells,” “tumor suppressor gene,” and “fibroblasts.” While in recent years, the research emphasis has shifted to “tumor microenvironment,” “epithelial mesenchymal transition,” “nanoparticles,” and “stem cells.”Conclusion: Taken together, our bibliometric analysis shows that caveolin continues to be of interest in cancer research. The hotspots and research frontiers have evolved from the regulation of cancer signaling, to potential targets of cancer therapy and novel techniques. These results can provide a data-based reference for the guidance of future research.
Intertemporal decision-making as a mediator between personality traits and self-management in type 2 diabetes: a cross-sectional study
Authors: Deng Linfang , Luo Shaoting , Fang Qianna , Xu Jinjiang 
Published: July 2023

ObjectivesThe aims to investigate the mediating effect of intertemporal decision-making on the association between personality traits and self-management among individuals with in Type 2 Diabetes (T2DM).MethodPatients with T2DM in the early stages of hospitalization at two tertiary hospitals in Shenyang and Jinzhou, Liaoning Province, May 2022 to January 2023. Questionnaires, including General Demographic, Self-Management, Big Five Personality, and Intertemporal Decision-Making, were administered. Pearson correlation analysis examined relationships between personality traits, intertemporal decision-making, and self-management. Hierarchical regression analysis identified self-management predictors. Mediation analysis used the PROCESS SPSS Macro version 3.3 model 4 to investigate intertemporal decision-making as mediator between personality traits and self-management.ResultsPearson correlation analysis revealed significant associations between self-management scores, personality traits, and intertemporal decision-making. Hierarchical regression revealed that Neuroticism and Conscientiousness accounted for 20.8% of the variance in self-management, while intertemporal decision-making explained 4.5% of the variance. Finally, using the Bootstrap method, the mediation analysis showed that intertemporal decision-making partially mediated the effect of personality traits on self-management.ConclusionThis study emphasizes the importance of intertemporal decision-making in improving self-management behaviors among patients with T2DM. Interventions targeted at modifying intertemporal decision-making preferences could be effective in enhancing self-management behaviors, leading to better health outcomes.
Association of frailty with health service use among older Chinese adults: analysis of population-based panel data
Authors: Yan Rui , Li Lifeng , Duan Xiaoran , Zhao Jie 
Published: July 2023

BackgroundFrailty is a common syndrome characterized by rapid growth in the aging population that has an impact on healthcare systems. This study aimed to investigate the impact of frailty on health service use and whether this effect varies with chronic diseases and socioeconomic status among older individuals in China.MethodsA balanced panel data analysis was conducted on 3,306 older individuals who completed follow-ups for the three waves of the China Health and Retirement Longitudinal Study (CHARLS) in 2011, 2013, and 2015. The Physical Frailty Phenotype (PFP) Scale was used to assess frailty status. Negative binomial regression was used to test the associations between frailty status, outpatient visits in the past 4 weeks, and annual inpatient hospital days.ResultsCompared with robust individuals, individuals with pre-frail or frail status were likely to report a higher number of outpatient visits [pre-frail: incidence rate ratio (IRR) = 1.28, 95% CI = 1.16–1.41; frail: IRR = 1.45, 95% CI = 1.23–1.71], and inpatient hospital days (pre-frail: IRR = 1.40, 95% CI = 1.24–1.58; frail: IRR = 2.17, 95% CI = 1.81–2.60) after controlling for all covariates. All five frailty components (weight loss, exhaustion, low physical activity, slowness, and weakness) were associated with a higher number of inpatient hospital days, and two components (weight loss and exhaustion) were associated with a higher number of outpatient visits. The effect of frailty on inpatient hospital stays persisted in different socioeconomic groups, across all health insurance programmes and physical comorbidities.ConclusionFrailty is associated with greater health service use among older individuals. Effective screening, prevention, intervention, and management of frailty may be important to reduce health service use.
Assessment of childhood immunization services at private healthcare facilities in Indonesia: a case study in a highly-populated city
Authors: Suwantika Auliya A. , Zakiyah Neily , Abdulah Rizky , Diantini Ajeng 
Published: July 2023

IntroductionThe need to enhance the utilization of the private sector for immunization programs in Indonesia while maintaining the high quality of services provided is evident. This study aimed to rapidly assess immunization services at private healthcare facilities in Indonesia by using Bandung, the most densely populated city, as the reference case.MethodsInitially, a situation analysis was conducted by collecting data from selected healthcare facilities (n = 9). Furthermore, a qualitative study was taken into account by developing framework approaches and conducting interviews with different layers, such as mid-level managers at healthcare facilities (n = 9), professional organizations (n = 4), and public stakeholders (n = 7).ResultsThe situation analysis showed that private healthcare facilities had provided sufficient time for essential childhood immunization services with adequate staff. Nevertheless, the number of limited staff the Ministry of Health (MoH) has trained remains a programmatic problem. Furthermore, private healthcare facilities have used the MoH guidelines and additional internal guidelines for immunization services as the primary reference, including in the efforts to provide complete and reliable equipment. Vaccine availability at private healthcare facilities is manageable with an acceptable out-of-stock level. The results of our interviews highlighted three key findings: the lack of coordination across public and private sectors, the need for immunization service delivery improvement at private healthcare facilities, and the urgency to strengthen institutional capacity for advocacy and immunization systems support.ConclusionEven though private healthcare facilities have been shown to make a modest contribution to childhood immunization services in Indonesia, efforts should be made to expand the role of private healthcare facilities in improving the performance of routine immunization programs.
Sex-specific associations between nine metal mixtures in urine and urine flow rate in US adults: NHANES 2009–2018
Authors: Zhang Shuai , Tang Hanhan , Zhou Minglian 
Published: July 2023

BackgroundThe urinary system serves as a crucial pathway for eliminating metallic substances from the body, making it susceptible to the effects of metal exposure. However, limited research has explored the association between metal mixtures and bladder function. This study aims to investigate the relationship between urinary metal mixtures (specifically barium, cadmium, cobalt, cesium, molybdenum, lead, antimony, thallium, and tungsten) and urine flow rate (UFR) in the general population, utilizing multiple mixture analysis models.MethodsThis study utilizes data obtained from the National Health and Nutrition Examination Survey. After adjusting for relevant covariates, we assessed the correlations between metal mixtures and UFR using three distinct analysis models: weighted quantile sum (WQS), quantile g-computation (qgcomp), and Bayesian kernel machine regression (BKMR). Additionally, a gender-stratified analysis was conducted. Finally, we also performed sensitivity analyses.ResultsA total of 7,733 subjects were included in this study, with 49% being male. The WQS regression model, when fitted in the positive direction, did not yield any significant correlations in the overall population or in the male and female subgroups. However, when analyzed in the negative direction, the WQS index exhibited a negative correlation with UFR in the overall group (β = −0.078; 95% CI: −0.111, −0.045). Additionally, a significant negative correlation between the WQS index and UFR was observed in the female group (β = −0.108; 95% CI: −0.158, −0.059), while no significant correlation was found in the male group. The results obtained from the qgcomp regression model were consistent with those of the WQS regression model. Similarly, the BKMR regression model revealed a significant negative correlation trend between metal mixtures and UFR, with cadmium and antimony potentially playing key roles.ConclusionOur study revealed a significant negative correlation between urinary metal mixture exposure and mean UFR in US adults, with notable gender differences. Specifically, higher urinary levels of cadmium and antimony were identified as potential key factors contributing to the decrease in mean UFR. These findings significantly contribute to the existing knowledge on the impact of metal mixtures on bladder function and provide valuable insights for safeguarding bladder health and preventing impaired bladder function.
Validation protocol for the evaluation of space-borne lidar particulate back-scattering coefficient bbp
Authors: Vadakke-Chanat Sayoob , Jamet Cédric 
Published: July 2023

Introduction: Space-borne lidar measurements from sensors such as CALIOP were recently used to retrieve the particulate back-scattering coefficient, bbp, in the upper ocean layers at a global scale and those observations have a strong potential for the future of ocean color with depth-resolved observations thereby complementing the conventional ocean color remote sensed observations as well as overcoming for some of its limitations. It is critical to evaluate and validate the space-borne lidar measurements for ocean applications as CALIOP was not originally designed for ocean applications. Few validation exercises of CALIOP were published and each exercise designed its own validation protocol. We propose here an objective validation protocol that could be applied to any current and future space-borne lidars for ocean applications.Methods: We, first, evaluated published validation protocols for CALIOP bbp product. Two published validation schemes were evaluated in our study, by using in-situ measurements from the BGC-Argo floats. These studies were either limited to day- or nighttime, or by the years used or by the geographical extent. We extended the match-up exercise to day-and nighttime observations and for the period 2010–2017 globally. We studied the impact of the time and distance differences between the in-situ measurements and the CALIOP footprint through a sensitivities study. Twenty combinations of distance (from 9-km to 50-km) and time (from 9 h to 16 days) differences were tested.Results &amp; Discussion: A statistical score was used to objectively selecting the best optimal timedistance windows, leading to the best compromise in term of number of matchups and low errors in the CALIOP product. We propose to use either a 24 h/9 km or 24 h/15 km window for the evaluation of space-borne lidar oceanic products.
Arabidopsis RAD16 Homologues Are Involved in UV Tolerance and Growth
Authors: Alrayes Linda , Stout Jake , Schroeder Dana 
Published: July 2023

In plants, prolonged exposure to ultraviolet (UV) radiation causes harmful DNA lesions. Nucleotide excision repair (NER) is an important DNA repair mechanism that operates via two pathways: transcription coupled repair (TC-NER) and global genomic repair (GG-NER). In plants and mammals, TC-NER is initiated by the Cockayne Syndrome A and B (CSA/CSB) complex, whereas GG-NER is initiated by the Damaged DNA Binding protein 1/2 (DDB1/2) complex. In the yeast Saccharomyces cerevisiae (S. cerevisiae), GG-NER is initiated by the Radiation Sensitive 7 and 16, (RAD7/16) complex. Arabidopsis thaliana has two homologues of yeast RAD16, At1g05120 and At1g02670, which we named AtRAD16 and AtRAD16b, respectively. In this study, we characterized the roles of AtRAD16 and AtRAD16b. Arabidopsis rad16 and rad16b null mutants exhibited increased UV sensitivity. Moreover, AtRAD16 overexpression increased plant UV tolerance. Thus, AtRAD16 and AtRAD16b contribute to plant UV tolerance and growth. Additionally, we found physical interaction between AtRAD16 and AtRAD7. Thus, the Arabidopsis RAD7/16 complex is functional in plant NER. Furthermore, AtRAD16 makes a significant contribution to Arabidopsis UV tolerance compared to the DDB1/2 and the CSB pathways. This is the first time the role and interaction of DDB1/2, RAD7/16, and CSA/CSB components in a single system have been studied.
Analisis Strategi Kebijakan Migrasi Internasional Pemerintahan Jokowi Jilid I Dalam Penanganan Human Trafficking
Authors: Marsel Bergitha Yesika , Sudey Narwastu Sharon , Nau Novriest Umbu W 
Published: July 2023

Migrasi Internasional merupakan fenomena yang menarik untuk dibahas ketika volume migrasi dalam masyarakat modern meningkat dalam jumlah skala yang besar. Dalam fenomena migrasi internasional ini, Pekerja Migran merupakan salah satu ranah yang rawan akan peluang terjadinya eksploitasi perdagangan manusia. Data statistik menurut BNP2TKI terkait naik turunnya grafik pendataan migran yang berprofesi sebagai TKI dalam periode waktu 2015-2019, kontras perbedaannya dengan laporan mengenai pekerja migran asal Indonesia yang menjadi korban dalam kasus human trafficking yang bergerak dalam grafik naik sebanyak 259 kasus pada Tahun 2019 dibanding laporan kasus pada Tahun 2018. Konstruktivisme meyakini antar masyarakat telah saling mengkonstruksi. Setiap tindakan selanjutnya terjadi karena pemaknaan tertentu, dan pemaknaan itu hadir sebagai hasil dari interaksi sosial. Faktor pendorong masyarakat untuk terlibat dalam migrasi internasional, dan tren migrasi internasional menjadi gagasan yang melandasi pemaknaan pola pikir masyarakat terkait dengan budaya migrasi internasional yang kemudian menghadirkan ruang peluang terjadinya perdagangan manusia. Sehingga berdasarkan definisi Universal Declaration of Human Right 1948, melihat seharusnya ada ruang pemulihan martabat serta kesejahteraan orang yang menjadi korban. Tulisan ini membahas pemaknaan konstruksi sosial domestik, menimbang kerangka kebijakan nasional mengenai Migrasi Internasional yang pernah dikeluarkan selama masa pemerintahan Presiden Joko Widodo Jilid 1 (2014-2019), yakni Undang-Undang No. 18 Tahun 2017.
Kata kunci: Human Trafficking, Migrasi Internasional, Pemerintahan Jokowi Jilid 1