bluuebunny/crossref_metadata_2025_split huggingface dataset:
Daily Sleep–Stress Reactivity and Functional Impairment in World Trade Center Responders
Authors: Messman Brett A , Slavish Danica C , Briggs Madasen , Ruggero Camilo J , Luft Benjamin J , Kotov Roman 
Published: April 2023

Abstract

Background
How sleep is impacted by stress (“sleep reactivity to stress”) and how stress is impacted by sleep (“stress reactivity to sleep”) are trait-like characteristics of individuals that predict depression, anxiety, and insomnia. However, pathways between reactivity and functional impairment (e.g., impairment in social relationships and interpersonal functioning) have not been explored, which may be a critical pathway in understanding the link between reactivity and the development of psychological disorders.

Purpose
We examined associations between reactivity and changes in functional impairment among a cohort of 9/11 World Trade Center responders.

Methods
Data from 452 responders (Mage = 55.22 years; 89.4% male) were collected between 2014 and 2016. Four baseline sleep and stress reactivity indices (i.e., sleep duration and efficiency reactivity to stress; stress reactivity to sleep duration and efficiency) were calculated from 14 days of sleep and stress data using random slopes from multilevel models. Functional impairment was assessed approximately 1 year and 2 years after baseline via semi-structured interviews. Latent change score analyses examined associations between baseline reactivity indices and changes in functional impairment.

Results
Greater baseline sleep efficiency reactivity to stress was associated with decreases in functioning (β = −0.05, p = .039). In addition, greater stress reactivity to sleep duration (β = −0.08, p = .017) and sleep efficiency (β = −0.22, p &lt; .001) was associated with lower functioning at timepoint one.

Conclusion
People who are more reactive to daily fluctuations in stress and sleep have poorer interpersonal relationships and social functioning. Identifying individuals with high reactivity who could benefit from preventative treatment may foster better social integration.
Goal-Focused Emotion-Regulation Therapy (GET) in Young Adult Testicular Cancer Survivors: A Randomized Pilot Study
Authors: Hoyt Michael A , Wang Ashley Wei-Ting , Ceja Raymond Carrillo , Cheavens Jennifer S , Daneshvar Michael A , Feldman Darren R , Funt Samuel A , Nelson Christian J 
Published: April 2023

Abstract

Background
Young adult testicular cancer survivors experience adverse impacts after treatment. We developed Goal-focused Emotion-regulation Therapy (GET) to improve distress symptoms, emotion regulation, and goal navigation skills.

Purpose
This pilot study examined GET versus an active control intervention in young adult survivors of testicular cancer.

Methods
Seventy-five eligible survivors treated with chemotherapy were randomized to receive GET or Individual Supportive Listening (ISL). Study acceptability, engagement, and tolerability were examined, and intervention fidelity and therapeutic alliance were compared between arms. Preliminary efficacy was evaluated by effect sizes for between-group changes in primary (anxiety and depressive symptoms) and secondary (career confusion, goal navigation, and emotion regulation) outcomes from baseline to immediately and 3-month post-intervention.

Results
Among the 38 men randomized to GET, 81.1% completed all study sessions compared with 82.4% of the 37 men assigned to ISL. Fidelity to the intervention was 87% in GET. Therapeutic alliance wassignificantly higher among those receiving GET versus ISL. Participants exhibited a medium group-by-time effect size with greater reductions in depressive (d = 0.45) and anxiety (d = 0.29) symptoms for those in GET versus ISL, with a similar pattern at 3 months for depressive (d = 0.46) and anxiety (d = 0.46) symptoms.

Conclusions
GET is a feasible and acceptable intervention for reducing adverse outcomes after testicular cancer for young adults. Observed effect sizes preliminarily suggest meaningful change, though should be interpreted with caution in small samples. GET may be a developmentally-matched behavioral approach to improve psychosocial function in this cancer group.

Clinical Trial information
Clinicaltrials.gov, NCT04150848. Registered on October 28, 2019.
The effectiveness of community ageing in place, advancing better living for elders as a biobehavioural environmental approach for disability among low-income older adults: a systematic review and meta-analysis
Authors: Rahmati Masoud , Keshvari Maryam , Koyanagi Ai , Yon Dong K , Lee Seung W , Shin Jae I , Smith Lee 
Published: April 2023

AbstractBackgroundcommunity ageing in place, advancing better living for elders (CAPABLE), which is a biobehavioural environmental approach by addressing individual capacities and the home environment, aims to reduce the impact of disability among low-income older adults.Objectivethis meta-analysis aims to elucidate the efficacy of the CAPABLE program on related outcomes in low-income older adults.Methodsa systematic search of MEDLINE/PubMed, CINAHL and EMBASE was conducted for articles published up to August 2022. A systematic review and meta-analysis were performed to calculate the pooled effect sizes of the efficacy of the CAPABLE program on home safety hazards, activities of daily living (ADLs), instrumental ADLs (IADLs), depression, falls efficacy, pain and quality of life.Resultsseven studies involving 2,921 low-income older adults (1,117 as the CAPABLE group and 1,804 served as a control) with an average age ranging from 65 to 79 were included in the present meta-analysis. Pre–post effect analyses showed that CAPABLE was significantly associated with lower home safety hazards, ADLs, IADLs, depression, falls efficacy, pain and quality of life. Additionally, there were statistically significant associations between the CAPABLE program with improvements in ADLs, IADLs and quality of life compared with controls.ConclusionCAPABLE intervention may be a promising strategy to reduce health disparities, and disability limitations, and improve the quality of life in low-income community-dwelling older adults who suffer from disabilities by addressing both the person and the environment.
Characterization of a TetR-type positive regulator AtrA for lincomycin production in Streptomyces lincolnensis
Authors: Wu Wei , Kang Yajing , Hou Bingbing , Ye Jiang , Wang Ruida , Wu Haizhen , Zhang Huizhan 
Published: April 2023

ABSTRACT
AtrA belongs to the TetR family and has been well characterized for its roles in antibiotic biosynthesis regulation. Here, we identified an AtrA homolog (AtrA-lin) in Streptomyces lincolnensis. Disruption of atrA-lin resulted in reduced lincomycin production, whereas the complement restored the lincomycin production level to that of the wild-type. In addition, atrA-lin disruption did not affect cell growth and morphological differentiation. Furthermore, atrA-lin disruption hindered the transcription of regulatory gene lmbU, structural genes lmbA and lmbW inside the lincomycin biosynthesis gene cluster, and 2 other regulatory genes, adpA and bldA. Completement of atrA-lin restored the transcription of these genes to varying degrees. Notably, we found that AtrA-lin directly binds to the promoter region of lmbU. Collectively, AtrA-lin positively modulated lincomycin production via both pathway-specific and global regulators. This study offers further insights into the functional diversity of AtrA homologs and the mechanism of lincomycin biosynthesis regulation.
Isomerization and epimerization of glucose and galactose in arginine solution and phosphate buffer under subcritical fluid conditions
Authors: Kobayashi Takashi , Khuwijitjaru Pramote , Adachi Shuji 
Published: April 2023

ABSTRACT
Reaction of glucose or galactose was performed in arginine solution or phosphate buffer (pH 7.0) using a batch reactor at 110°C. The yields of products, pH, and absorbances at 280 and 420 nm were measured during the reaction. Fructose, mannose, and allulose were formed from glucose; tagatose, talose, and sorbose were done from galactose. The reaction proceeded more rapidly in arginine solution than in phosphate buffer. In arginine solution, yields of fructose and tagatose were 20% and 16%, respectively, after 30-min reaction; in phosphate buffer, they were 14% and 10%, respectively. However, in both reaction media, the pH drop and increase in absorbances continued even after the yield became almost constant. The absorbance increased particularly in the latter half of the reaction due to formation of browning products. Therefore, to avoid browning, the reaction should be stopped as soon as possible after the yield approaches its maximum value.
Adaptive deep propagation graph neural network for predicting miRNA–disease associations
Authors: Hu Hua , Zhao Huan , Zhong Tangbo , Dong Xishang , Wang Lei , Han Pengyong , Li Zhengwei 
Published: April 2023

Abstract

Background
A large number of experiments show that the abnormal expression of miRNA is closely related to the occurrence, diagnosis and treatment of diseases. Identifying associations between miRNAs and diseases is important for clinical applications of complex human diseases. However, traditional biological experimental methods and calculation-based methods have many limitations, which lead to the development of more efficient and accurate deep learning methods for predicting miRNA–disease associations.

Results
In this paper, we propose a novel model on the basis of adaptive deep propagation graph neural network to predict miRNA–disease associations (ADPMDA). We first construct the miRNA–disease heterogeneous graph based on known miRNA–disease pairs, miRNA integrated similarity information, miRNA sequence information and disease similarity information. Then, we project the features of miRNAs and diseases into a low-dimensional space. After that, attention mechanism is utilized to aggregate the local features of central nodes. In particular, an adaptive deep propagation graph neural network is employed to learn the embedding of nodes, which can adaptively adjust the local and global information of nodes. Finally, the multi-layer perceptron is leveraged to score miRNA–disease pairs.

Conclusion
Experiments on human microRNA disease database v3.0 dataset show that ADPMDA achieves the mean AUC value of 94.75% under 5-fold cross-validation. We further conduct case studies on the esophageal neoplasm, lung neoplasms and lymphoma to confirm the effectiveness of our proposed model, and 49, 49, 47 of the top 50 predicted miRNAs associated with these diseases are confirmed, respectively. These results demonstrate the effectiveness and superiority of our model in predicting miRNA–disease associations.
The DynaSig-ML Python package: automated learning of biomolecular dynamics–function relationships
Authors: Mailhot Olivier , Major François , Najmanovich Rafael 
Published: April 2023

Abstract The DynaSig-ML (‘Dynamical Signatures–Machine Learning’) Python package allows the efficient, user-friendly exploration of 3D dynamics–function relationships in biomolecules, using datasets of experimental measures from large numbers of sequence variants. It does so by predicting 3D structural dynamics for every variant using the Elastic Network Contact Model (ENCoM), a sequence-sensitive coarse-grained normal mode analysis model. Dynamical Signatures represent the fluctuation at every position in the biomolecule and are used as features fed into machine learning models of the user’s choice. Once trained, these models can be used to predict experimental outcomes for theoretical variants. The whole pipeline can be run with just a few lines of Python and modest computational resources. The compute-intensive steps are easily parallelized in the case of either large biomolecules or vast amounts of sequence variants. As an example application, we use the DynaSig-ML package to predict the maturation efficiency of human microRNA miR-125a variants from high-throughput enzymatic assays.Availability and implementationDynaSig-ML is open-source software available at https://github.com/gregorpatof/dynasigml_package.
Molecular property prediction by contrastive learning with attention-guided positive sample selection
Authors: Wang Jinxian , Guan Jihong , Zhou Shuigeng 
Published: April 2023

Abstract

Motivation
Predicting molecular properties is one of the fundamental problems in drug design and discovery. In recent years, self-supervised learning (SSL) has shown its promising performance in image recognition, natural language processing, and single-cell data analysis. Contrastive learning (CL) is a typical SSL method used to learn the features of data so that the trained model can more effectively distinguish the data. One important issue of CL is how to select positive samples for each training example, which will significantly impact the performance of CL.

Results
In this article, we propose a new method for molecular property prediction (MPP) by Contrastive Learning with Attention-guided Positive-sample Selection (CLAPS). First, we generate positive samples for each training example based on an attention-guided selection scheme. Second, we employ a Transformer encoder to extract latent feature vectors and compute the contrastive loss aiming to distinguish positive and negative sample pairs. Finally, we use the trained encoder for predicting molecular properties. Experiments on various benchmark datasets show that our approach outperforms the state-of-the-art (SOTA) methods in most cases.

Availability and implementation
The code is publicly available at https://github.com/wangjx22/CLAPS.
Oscillatory dynamics serving visual selective attention during a Simon task
Authors: Son Jake J , Arif Yasra , Schantell Mikki , Willett Madelyn P , Johnson Hallie J , Okelberry Hannah J , Embury Christine M , Wilson Tony W 
Published: April 2023

Abstract
Selective attention is an important component of cognitive control and is essential for day-to-day functioning. The Simon task is a common test of visual selective attention that has been widely used to probe response selection, inhibition and cognitive control. However, to date, there is a dearth of literature that has focused on the oscillatory dynamics serving task performance in the selective attention component of this task. In this study, 32 healthy adults (mean age: 33.09 years, SD: 7.27 years) successfully completed a modified version of the Simon task during magnetoencephalography. All magnetoencephalographic data were pre-processed and transformed into the time–frequency domain. Significant oscillatory brain responses were imaged using a beamforming approach, and peak task-related neural activity was extracted to examine the temporal dynamics. Across both congruent and Simon conditions, our results indicated robust decreases in alpha (8–12 Hz) activity in the bilateral occipital regions and cuneus during task performance, while increases in theta (3–6 Hz) oscillatory activity were detected in regions of the dorsal frontoparietal attention network, including the dorsolateral prefrontal cortex, frontal eye fields and insula. Lastly, whole-brain condition-wise analyses showed Simon interference effects in the theta range in the superior parietal region and the alpha range in the posterior cingulate and inferior frontal cortices. These findings provide network-specific insights into the oscillatory dynamics serving visual selective attention.
How to do digital Advice and Guidance well
Authors: Charman Carolyn , Wainman Hannah , Rabindranathnambi Aswatha , Whybrew Chin , Williams Hywel C 
Published: April 2023

Abstract
The COVID-19 pandemic has accelerated a rapid expansion of digital Advice and Guidance (A&G) across UK medical and surgical specialties. Dermatology A&G requests have increased by over 400% since the onset of the pandemic in 2020, with rapid expansion of teledermatology A&G services across England. Dermatology A&G is usually carried out asynchronously through dedicated digital platforms such as the National Health Service e-referral service, with streamlined conversion to referral if clinically indicated. A&G with images is advocated as the main referral pathway to dermatology specialist services in England (excluding the 2-week wait suspected skin cancer pathway). Providing dermatological care through A&G requires specific clinical skill sets to ensure rapid, safe and collaborative delivery, and optimization of educational benefit. Little published guidance is available to signpost clinicians to what constitutes a high-quality A&G request and response. This educational article discusses good clinical practice based on extensive local and national experience from primary and secondary care doctors. We cover digital communication skills, shared decision making, clinical competency and building collaborative links between patients, referrers and specialists. High-quality A&G, with agreed turn-around times and optimization of technology, can significantly streamline patient care and strengthen links between clinicians, providing it is appropriately resourced within the wider planning of elective care and outpatient activity.
Breastfeeding Among People With Human Immunodeficiency Virus in North America: A Multisite Study
Authors: Levison Judy , McKinney Jennifer , Duque Alejandra , Hawkins Joanna , Bowden Emily Ver Hoeve , Dorland Julie , Bitnun Ari , Kazmi Kescha , Campbell Douglas M , MacGillivray Jay , Yudin Mark H , Powell Anna , Datta Shreetoma , Abuogi Lisa , Weinberg Adriana , Rakhmanina Natella , Mareuil Joanna Walsh , Hitti Jane , Boucoiran Isabelle , Kakkar Fatima , Rahangdale Lisa , Seidman Dominika , Widener Rebecca 
Published: April 2023

Abstract

Background
In North American countries, national guidelines have strongly recommended formula over breastmilk for people with human immunodeficiency virus (HIV) because of concern for HIV transmission. However, data from resource-limited settings suggest the risk is &lt;1% among virally suppressed people. Information regarding breastfeeding experience in high-resource settings is lacking.

Methods
A retrospective multisite study was performed for individuals with HIV who breastfed during 2014–2022 in the United States (8 sites) and Canada (3 sites). Descriptive statistics were used for data analysis.

Results
Among the 72 cases reported, most had been diagnosed with HIV and were on antiretroviral therapy prior to the index pregnancy and had undetectable viral loads at delivery. Most commonly reported reasons for choosing to breastfeed were health benefits, community expectations, and parent–child bonding. Median duration of breastfeeding was 24 weeks (range, 1 day to 72 weeks). Regimens for infant prophylaxis and protocols for testing of infants and birthing parents varied widely among institutions. No neonatal transmissions occurred among the 94% of infants for whom results were available ≥6 weeks after weaning.

Conclusions
This study describes the largest cohort to date of people with HIV who breastfed in North America. Findings demonstrate high variability among institutions in policies, infant prophylaxis, and infant and parental testing practices. The study describes challenges in weighing the potential risks of transmission with personal and community factors. Finally, this study highlights the relatively small numbers of patients with HIV who chose to breastfeed at any 1 location, and the need for further multisite studies to identify best care practices.
Chronic Aichi Virus Infection As a Cause of Long-Lasting Multiorgan Involvement in Patients With Primary Immune Deficiencies
Authors: Fourgeaud Jacques , Lecuit Mathilde M , Pérot Philippe , Bruneau Julie , Regnault Beatrice , Da Rocha Nicolas , Bessaud Mael , Picard Capucine , Jeziorski Éric , Fournier Benjamin , Levy Romain , Marçais Ambroise , Blanche Stéphane , Frange Pierre , Fischer Alain , Cavazzana Marina , Ferroni Agnès , Jamet Anne , Leruez-Ville Marianne , Eloit Marc , Neven Bénédicte 
Published: April 2023

Abstract

Background
Metagenomic next-generation sequencing (mNGS) was used to assess patients with primary or secondary immune deficiencies (PIDs and SIDs) who presented with immunopathological conditions related to immunodysregulation.

Methods
Thirty patients with PIDs or SIDs who presented with symptoms related to immunodysregulation and 59 asymptomatic patients with similar PIDs or SIDs were enrolled. mNGS was performed on organ biopsy. Specific Aichi virus (AiV) reverse-transcription polymerase chain reaction (RT-PCR) was used to confirm AiV infection and screen the other patients. In situ hybridization (ISH) assay was done on AiV-infected organs to identify infected cells. Virus genotype was determined by phylogenetic analysis.

Results
AiV sequences were detected using mNGS in tissue samples of 5 patients and by RT-PCR in peripheral samples of another patient, all of whom presented with PID and long-lasting multiorgan involvement, including hepatitis, splenomegaly, and nephritis in 4 patients. CD8+ T-cell infiltration was a hallmark of the disease. RT-PCR detected intermittent low viral loads in urine and plasma from infected patients but not from uninfected patients. Viral detection stopped after immune reconstitution obtained by hematopoietic stem cell transplantation. ISH demonstrated the presence of AiV RNA in hepatocytes (n = 1) and spleen tissue (n = 2). AiV belonged to genotype A (n = 2) or B (n = 3).

Conclusions
The similarity of the clinical presentation, the detection of AiV in a subgroup of patients suffering from immunodysregulation, the absence of AiV in asymptomatic patients, the detection of viral genome in infected organs by ISH, and the reversibility of symptoms after treatment argue for AiV causality.
Link between myocardial deformation phenotyping using longitudinal and circumferential strain and risk of incident heart failure and cardiovascular death
Authors: Skaarup Kristoffer Grundtvig , Lassen Mats Christian Højbjerg , Johansen Niklas Dyrby , Sengeløv Morten , Olsen Flemming Javier , Jensen Gorm Boje , Schnohr Peter , Shah Amil , Claggett Brian Lee , Solomon Scott D , Møgelvang Rasmus , Biering-Sørensen Tor 
Published: April 2023

Abstract

Aims
Left ventricular (LV) systolic deformation is altered early in the ventricular disease process despite normal LV ejection fraction (LVEF). These alterations seem to be characterized by decreased global longitudinal strain (GLS) and augmented global circumferential strain (GCS). This study aimed to investigate the link between myocardial deformation phenotyping using longitudinal and circumferential strain and risk of incident heart failure (HF) and cardiovascular death (CD).

Methods and results
The study sample was based on the prospective cohort study the 5th Copenhagen City Heart Study (2011–15). All participants were examined with echocardiography following a pre-defined protocol. A total of 2874 participants were included. Mean age was 53±18 years and 60% were female. During a median follow-up of 3.5 years, a total of 73 developed HF/CD. A U-shaped relationship between GCS and HF/CD was observed. LVEF significantly modified the association between GCS and HF/CD (P for interaction &lt;0.001). The optimal transition point for the effect modification was LVEF &lt; 50%. In multivariable Cox regressions, increasing GCS was significantly associated with HF/CD in participants with LVEF ≥ 50% (hazard ratio [HR]=1.12 [95% confidence interval (CI): 1.02; 1.23] per 1% increase), while decreasing GCS was associated with a higher risk of HF/CD in individuals with LVEF &lt; 50% [HR=1.18 (95% CI: 1.05; 1.31) per 1% decrease].

Conclusions
The prognostic utility of GCS is modified by LVEF. In participants with normal LVEF, higher GCS was associated with increased risk of HF/CD, while the opposite was observed in participants with abnormal LVEF. This observation adds important information to our understanding of the pathophysiological evolution of myocardial deformation in cardiac disease progression.