bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multifocal glioblastoma and hormone replacement therapy in a transgender female
Authors: Santellan-Hernandez Jose Omar , Alvarez-Castro José Alfonso , Aguilar-Hidalgo Keren Magaly , Soto Fernando Castro , Escalante Jonathan Ramos , Ichikawa-Escamilla Eduardo , Silva Maria Jose Alvarez , Mejia-Perez Sonia Iliana 
Published: March 2023

Background:
Glioblastoma multiforme represents approximately 60% of all brain tumors in adults. This malignancy shows a high level of biological and genetic heterogeneity associated with exceptional aggressiveness, leading to poor patient survival. One of the less common presentations is the appearance of primary multifocal lesions, which are linked with a worse prognosis. Among the multiple triggering factors in glioma progression, the administration of sex steroids and their analogs has been studied, but their role remains unclear to date.

Case Description:
A 43-year-old transgender woman who has a personal pathological history of receiving intramuscular (IM) hormone treatment for 27 years based on algestone/estradiol 150 mg/10 mg/mL. Three months ago, the patient suddenly experienced hemiplegia and hemiparesis in her right lower extremity, followed by a myoclonic focal epileptic seizure, vertigo, and a right frontal headache with a visual analog scale of 10/10. Magnetic resonance imaging images revealed an intra-axial mass with poorly defined, heterogeneous borders, and thick borders with perilesional edema in the left parietal lobe, as well as a rounded hypodense image with well-defined walls in the right internal capsule. The tumor was resected, and samples were sent to the pathology department, which confirmed the diagnosis of wild-type glioblastoma.

Conclusion:
This report identifies prolonged use of steroid-based hormone replacement therapy as the only predisposing factor in the oncogenesis of multifocal glioblastoma. It is an example that highlights the importance for physicians not to consider pathologies related to the human immunodeficiency virus rather than neoplasms in transgender patients in view of progressive neurological deterioration.
Tick-borne encephalitis virus IgG antibody surveillance: vaccination- and infection-induced seroprevalences, south-western Germany, 2021
Authors: Euringer Kathrin , Girl Philipp , Kaier Klaus , Peilstöcker Jan , Schmidt Michael , Müller-Steinhardt Michael , Rauscher Beate , Bressau Evelyn , Kern Winfried V , Dobler Gerhard , Borde Johannes P 
Published: March 2023

Background
The exact epidemiology of tick-borne encephalitis virus (TBEV) infections is unknown because many TBEV infections have an influenza-like or asymptomatic course. Surveillance data are based on patients with any (predominantly neurological) symptoms that prompted diagnostic testing. Infection- and vaccine-induced antibodies against TBEV can be distinguished using an NS1 IgG ELISA.

Aim
In a seroprevalence study we aimed to investigate TBEV antibody prevalence, incidences, manifestation indices and potential protection rates in a highly endemic district in south-western Germany.

Methods
We analysed 2,220 samples from healthy blood donors collected between May and September 2021. The reported number of TBEV infections was provided on a sub-district level by the local public health authorities. Blood samples were first screened using a TBEV IgG ELISA. In a second step, all positive samples were further analysed with a recently established NS1 IgG ELISA. The presence of specific antibodies against TBEV (excluding cross-reacting antibodies against other flaviviruses) was confirmed by testing screening-positive samples with a microneutralisation assay.

Results
Of 2,220 included samples, 1,257 (57%) tested positive by TBEV IgG ELISA and 125 tested positive for infection-induced TBEV NS1 antibodies, resulting in a TBEV NS1 IgG seroprevalence at 5.6% in our population. The yearly incidence based on the NS1 ELISA findings resulted in 283 cases per 100,000 inhabitants.

Conclusion
Using the TBEV NS1 IgG assay, we confirmed a manifestation index of ca 2% and a high incidence of predominantly silent TBEV infections (> 250/100,000/year), which exceeds the incidence of notified cases (4.7/100,000/year) considerably.
A new method for near real-time, nationwide surveillance of nosocomial COVID-19 in Norway: providing data at all levels of the healthcare system, March 2020 to March 2022
Authors: Skagseth Håvard , Jørgensen Silje Bakken , Reilly Jacqui , Kacelnik Oliver 
Published: March 2023

Background
Great efforts have been made to minimise spread and prevent outbreaks of COVID-19 in hospitals. However, there is uncertainty in identifying nosocomial vs community-acquired infections. To minimise risks and evaluate measures, timely data on infection risk in healthcare institutions are required.

Aims
To design an automated nationwide surveillance system for nosocomial COVID-19 using existing data to analyse the impact of community infection rates on nosocomial infections, to explore how changes in case definitions influence incidence and to identify patients and wards at highest risk and effects of SARS-CoV-2 variants.

Methods
We used data from the Norwegian real-time emergency preparedness register (Beredt C19), which includes all patients nationwide admitted to Norwegian hospitals between March 2020 and March 2022 with a positive SARS-CoV-2 PCR test during their hospital stay or within 7 days post-discharge. COVID-19 cases were assigned to categories depending on the time between admission and testing.

Results
Infection rates for definite/probable nosocomial COVID-19 increased from 0.081% in year 1 to 0.50% in year 2 in hospital admissions 7 days or longer. Varying the definitions resulted in large changes in registered nosocomial infections. Infection rates were similar across different ward types. By 2022, 58% of patients with a definite/probable nosocomial infection had received three vaccine doses.

Conclusion
Automated national surveillance for nosocomial COVID-19 is possible based on existing data sources. Beredt C19 provided detailed information with only 5% missing data on hospitals/wards. Epidemiological definitions are possible to standardise, enabling easier comparison between regions and countries.
Program and results of experimental studies of the characteristics of fiber concrete produced by the mechanical technology of creating aggregate oriented fiber reinforcement
Authors: Mailyan Levon , Shilov Petr , Shilov Aleksandr 
Published: March 2023

Statement of the problem. The pace of development of modern construction creates the need to develop new technologies that make it possible to impart special properties to classical building materials, allowing them to expand the range of their application. The developed technology of mechanical distribution and orientation along the fiber fibers acting in the structure of tensile stresses in the body of linear fiber-reinforced concrete and fiber-reinforced concrete elements can provide more efficient use of fiber-dispersed reinforcement by including more fibers in the work of the section. It is necessary to develop a program of experimental studies of the strength and deformation properties of fiber-reinforced concrete in order to test the technology of laying fiber-reinforced concrete mixture developed by the authors.
Results. A program of experimental studies of the strength and deformation characteristics of fiber-reinforced concrete, manufactured using the mechanical technology for creating aggregated oriented fiber reinforcement, is presented. The results of experiments carried out in accordance with the developed program are also presented.
Conclusions. The presented program of experimental studies of the characteristics of fiber-reinforced concrete, made according to the technology developed by the authors for the mechanical creation of aggregated oriented fiber reinforcement, became the basis for experimental studies, the purpose of which was to test the technology developed by the authors for the mechanical laying of a fiber-reinforced concrete mixture with a uniform distribution of fiber fibers in a concrete matrix, as well as obtaining new data on the mechanical and deformative properties of such fiber-reinforced concrete.
Method of using georadiolocation to control the serviceability of structures during their life cycle
Authors: Haydar A. , Zheleznov Maksim 
Published: March 2023

Advances in structural health monitoring are helping professionals identify potential building hazards caused by aging and other environmental factors.
Monitoring the state of structures primarily allows you to examine the current state of structural systems to assess their functional suitability and performance level. If the assessment of the condition of the structure reveals a lower level of performance than required, then work should be carried out immediately to restore and reconstruct it. , and specialists who monitor the state of "health" of buildings.
The Effects of the Traditional Data Augmentation Techniques on Long Bone Fracture Detection
Authors: CANGÖZ Gülnur Begüm , GÜNEY Selda 
Published: March 2023

Image collection and preparation phases are highly costly for machine learning
algorithms. They require the majority of labeled data. Hence, the image pre-processing method, data augmentation, is commonly used. Since there are so many proposed methods for the augmentation task, this comparison study is presented to be a supporting guide for the researchers. In addition, the lack of studies with animal-based data sets makes this study more valuable. The study is investigated on a comprehensive medical image data set consists of X-ray images of many different dogs. The main goal is to determine the fracture of the long bones in dogs. Many traditional augmentation methods are employed on the data set including flipping, rotating, changing brightness and contrast of the images. Transfer learning is applied on both raw and augmented data sets as a feature extractor and Support Vector Machine (SVM) is utilized as a classifier. For the classification task, the experimental study shows that changing the contrast is the outstanding method for accuracy manner, while the rotation method has the best sensitivity value.
KRİPTO PARA FİYATLARININ LSTM VE GRU MODELLERİ İLE TAHMİNİ
Authors: DEMİRCİ Esranur , KARAATLI Meltem 
Published: March 2023

Yakın geçmişte hayatımıza giren ve kısa zamanda finansal piyasalarda kendisine yer bulan kripto paralar, hem bir değişim aracı hem de bir yatırım aracı olarak kullanılmaktadır. Kripto paraların merkezi bir otoritenin kontrolünde olmaması bu araçların fiyatlarında dalgalanmaları beraberinde getirmiştir. Bu nedenle, akıllı bir tahmin modelinin geliştirilmesi, yatırım yapılacak finansal varlıkların seçimi ve yatırım kararlarının hayata geçirilmesi açısından oldukça önemlidir.
Derin öğrenme ve yapay zeka, yatırım yapılacak olan kripto para birimi ve diğer yatırım araçlarının seçiminde kullanılmaktadır. Tekrarlayan Sinir Ağı (RNN), Uzun-Kısa Süreli Bellek (LSTM) ve Geçitli Yinelenen Birim (GRU) modeli gibi derin öğrenme modellerinin, kripto para birimi fiyat tahmininde geleneksel zaman serisi modellerinden daha iyi performans gösterdiği araştırmacılar tarafından kanıtlanmıştır. Bundan dolayı bu çalışmada, özel bir RNN yöntemi olan LSTM ve GRU’dan yararlanılarak, günümüzde piyasa değeri ve işlem hacmi en yüksek olan kripto paralardan Bitcoin, Ethereum ve Ripple’ın 30 günlük fiyat tahmininde bulunulmuştur. Araştırmanın sonucunda her iki modelde de en iyi tahmin sonucunu Bitcoin vermiştir. İkinci en iyi tahmin sonucu Ripple, sonrasında ise Ethereum için bulunmuştur. Kullanılan yöntemler karşılaştırıldığında ise MAPE performans ölçütüne göre en iyi tahmin sonucuna Bitcoin ve Ripple için GRU, Ethereum için ise LSTM modeli ile ulaşılmıştır.
The excessive use of sulphur and creation of stomme as an early modern cellar technique in Dutch wine trade
Authors: Beukers Mariëlla , Blijleven Rob 
Published: March 2023

<p>On the basis of study of early modern literature and other period sources we describe the production and use of <em>stomme</em>, used by Dutch wine merchants in the 17th, 18th and 19th century. We conclude that <em>stomme </em>was made by using excessive amounts of sulphur dioxide, thereby creating health hasards. The States General of the Dutch Republic acknowledged that danger, and banned the use of <em>stomme </em> in 1613. However, the ban was never implemented and <em>stomme </em>remained in use for a long time. We argue that the ban was inspired by the risks posed to the health of the wine drinkers, but that economic reasons for a continuance of use prevailed. </p>
Discurso, termómetro da competição política: Os primeiros meses de oposição do 18.º Presidente do PSD ao XXI Governo Português
Authors: Dos Santos Edmilson Gomes 
Published: March 2023

Com este artigo propõe-se elaborar sobre a relação existente entre o discurso político e a competição política, e dissertar sobre a competição político-partidária em Portugal nos primeiros meses de Rui Rio à frente do principal partido na oposição, o Partido Social Democrata. Pretende-se alcançar o segundo objetivo referido a partir da análise da interação discursiva, publicada em jornais, entre o chefe do XXI Governo Constitucional de Portugal e o líder do principal partido na oposição. Na primeira parte, é apresentada uma elaboração teórica sobre os vários conceitos implicados na relação estudada; de seguida, são expostos os procedimentos e resultados do estudo empírico levado a cabo. Argumenta-se que, pela natureza comunicacional da política, o discurso político pode ser um indicador do nível da competição político-partidária. Chegou-se à conclusão de que, no período analisado, houve um elevado nível de convergência no discurso, entre os líderes dos partidos estudados, o que aponta para a existência de um fraco nível de competição política em Portugal.
Pengaruh Kualitas Audit,Audit Tenure,Profitabilitas,Pertumbuhan Perusahaan terhadap Opini Audit Going Concern pada Perusahaan Pertambangan Yang Terdaftar di BEI Tahun 2016-2019
Authors: Parhusip Ono , Hutasoit Elfrida Fitri , Ginting Wenny Anggeresia 
Published: March 2023

This research was conducted to test and analyze whether the quality of audit, audit tenure, profitability, growth of the company influences the opinion of audit going concerned on mining companies listed on the Indonesia Stock Exchange for the period 2016-2019. The research method used quantitative method and research data obtained from www.IDX.co.id and research population of 47 companies, sampling is used purposive sampling techniques so that the samples in this study as many as 17 companies and this research using logistic regression test. The significance value obtained from the results of simultaneous hypothesis testing amounted to 0.007 < 0.05 that the quality of audits, audit tenure, profitability, growth of the company influenced the opinion of the audit going concerned. The significance values indicated from partial hypothesis testing were audit quality of 0.998 > 0.05, audit tenure of 0.419 > 0.05, profitability of 0.540 > 0.05, and company growth of 0.816 > 0.05. It can be seen that the quality of audits, audit tenure, profitability, and growth of the company are not partially impacted by the opinion of the audit going concerned.

Keywords: Audit Quality, Audit Tenure, Profitability, Company Growth, Going Concern
Earning Per Share Memoderasi Pengaruh Debt to Equity Ratio terhadap Harga Saham di Bursa Efek Indonesia
Authors: Mahardika Guntar , Hersona Sonny , Nurhasanah Nunung 
Published: March 2023

This study aims to determine the effect of Debt To Equity Ratio (DER) on Stock Prices with Earning Per Share (EPS) as a moderating variable. The data used in this study are secondary data on the IDX and the company's annual report. The population used in this study was conducted on Textile and Garment Sub-sector companies listed on the IDX for the period 2012-2019. The analytical technique used is the MRA (Moderated Regression Analysis) test. The results showed that DER did not affect stock prices. EPS has an effect on stock prices. Testing the moderating variable in this study shows that EPS moderates the effect of DER on stock prices. The moderation test shows that a higher EPS value will be stronger in mitigating the effect of DER on stock prices.
Keywords: Debt to Equity Ratio, Earning Per Share and Stock Price.
Pengaruh Komunikasi Kerja , Kepemimpinan dan Pelatihan kerja terhadap Kepuasan Kerja karyawan PT. Sepatu Bata
Authors: Situmorang Juanda , Dewi Yuli Rama , Ginting Monarisa Ritiani Br , Khairani Rafida 
Published: March 2023

This study aims to determine the effect of work communication on job satisfaction of employees of PT. Sepatu Bata, knowing the influence of leadership on job satisfaction of employees of PT. Sepatu Bata, knowing the effect of job training on job satisfaction of employees of PT Sepatu Bata and knowing the effect of work communication, leadership and job training simultaneously on job satisfaction of employees of PT Sepatu Bata is implemented at PT Sepatu Bata with a population of all 25 employees of PT Sepaatu Bata. By using total sampling, this research sample obtained 25 people. The results of the research partially obtained the tcount of work communication (X1) was 3.043 and the t table value was 2.059 provided that the value of tcount> t table (3.043> 2.059) and the value of sig <0.06 (0.000 <0.05), the value of tcount of leadership ( X2) is 2.720 and the t-table value is 2.059 provided that the tcount> ttable (2.720> 2.059) and the sig value <0.05 (0.013 <0.05), the tcount value for job training (X3) is 3.720 and the t table value is 2.059 with provisions for the value of tcount> ttable (3.207> 2.059) and the value of sig <0.05 (0.004 <0.05), the simultaneous effect of the Fcount value of work communication (X1), leadership (X2) and job training (X3) is 39.728 and the value t table is 2.758 with the provision that the value of Fcount> Ftable (39.728> 2.758) and the sig value <0.05 (0.000 <0.05. The Adjusted RSquare value is 0.829 or adjusted R2 x 100% of 82.90%, meaning that the independent research variable is in the form of Work communication, leadership and job training contribute ih great in explaining the job satisfaction of 82.90% while the remaining 17.10% is influenced by other factors outside the research. The conclusion of the study is partially job communication has a significant effect on job satisfaction, leadership has a significant effect on job satisfaction, job training has a significant effect and is a dominant variable that affects job satisfaction and simultaneously job communication, leadership and job training have a significant effect on job satisfaction.
Keywords : job communication, leadership, job training, job satisfaction
Analisis Kapabilitas Pemasaran E-Commerce Dalam Menciptakan Efektivitas Promosi Dan Strategi Bersaing (Studi Kasus pada UMKM Sektor Perdagangan Kota Sukabumi)
Authors: Inggriyani Anak Agung Putu Ayu , Danial R Deni Muhammad , Samsudin Acep 
Published: March 2023

This study aims to determine the effect of E-commerce marketing capabilities in creating the effectiveness of promotions and competitive strategies carried out on SMEs in the trading sector in Sukabumi City. The research method used is a quantitative method with a descriptive and associative approach, The sample used is 70 companies that have met the criteria of 226 population members using random sampling method. Probability sampling approach so that the number of samples studied is 70 data from January 1 to May 31, 2021. The data collection technique used is secondary data including documentation and literature study. The data analysis technique used is linear regression. Based on the results of this study, it shows that partially there is a significant influence of e-commerce marketing capabilities on the effectiveness of promotions then partially e-commerce marketing capabilities have a significant effect on competitive strategy and simultaneously e-commerce marketing capabilities have a significant effect on the effectiveness of promotions and strategies. compete in the MSME trade sector in Sukabumi City.
Keywords: E-commerce Marketing Capability, Promotion Effectiveness, and Competitive Strategy
Optimalisasi Kinerja Karyawan Melalui Penempatan Kerja Dan Pengembangan Karir
Authors: Widiastuti Ervina , Z Faizal Mulia , Norisanti Nor 
Published: March 2023

PT Pratama Abadi Industri is a company that absorbs enough manpower, this company considers the placement of employees to be an important issue to pay attention to, among others, in the context of optimizing existing human capabilities in order to produce employees who excel according to the abilities and knowledge needed. The purpose of this study was to measure the effect of job placement and development on employee performance. The method used in this research is descriptive method and associative method with a quantitative approach. The sampling technique in this study used probability sampling using simple random sampling, which involved 100 employees at PT Pratama Abadi Industri. The data analysis technique used is multiple linear regression analysis, including the coefficient of determination test, multiple correlation coefficient, simultaneous test (F test) and partial test (T test). The results of the study, using the F test the probability value of sig. 0.00 < 0.05 which means that joint work placement (X1) and career development (X2) have a significant effect on employee performance (Y). While the t test shows that work placement (X1) hasn’t a significant effect on employee performance (Y) and career development (X2) has a significant effect on employee performance (Y).
Keywords: Work Placement; Career development; Employee performance.
Studi Analisis Penilaian Kinerja Dengan Metode Balanced Scorecard Pada CV. Langgeng Abadi Body Repair
Authors: Handoyo Ugroseno Damara Prasadhana , Junaedi Wahyu , Pebrianto Dede 
Published: March 2023

The Balanced Scorecard is used by companies to measure their performance as a more comprehensive measurement tool or technique because it uses two parameters, namely financial and non-financial. The industrial management method with the Balanced Scorecard approach is very easy to apply, even to small home industries because it does not require a fee. The application of management methods with the Balanced Scorecard analysis approach in small and medium-sized industries can see all aspects that can affect the profit and sustainability of the company. And in the end, the company was able to develop its industry on a much larger scale.

Keywords: company performance appraisal, Balanced Scorecard method
Pentingnya Pengalaman Kerja Dan Gender Terhadap Kualitas Kerja Karyawan
Authors: Mitasari Mitasari , Samsudin Acep , Norisanti Nor 
Published: March 2023

This study aims to determine the effect of work experience and gender on the quality of work of employees. This research uses descriptive method and associative method with quantitative approach. The population in this study are employees of the production division of PT. Star Comgistic Indonesia and the sample used were 280 respondets. The data analysys technique used is multiple linear regression analysis and the sample technique used is proportionate stratified random sampling. The result of this study indicate that simultaneously and partially the work experience and gender variables have a positive and significant effect on the quality of work of employees. The result of the f test are known from the fcount 168,672 > 3,028, indicating that the fcount value is greater than ftable and from the correlation result in this study, it has a strong and high value of 0,549. Meanwhile, from the results of the t test values, namely tcount 6,847 > 1,968, it shows than ttable so it can be concluded that work experience and gender have an influence on work quality.
Keywords : Work Experience, Gender, Quality of Work