bluuebunny/crossref_metadata_2025_split huggingface dataset:
RET rearrangements are relevant to histopathologic subtypes and clinicopathological features in Thai papillary thyroid carcinoma patients
Authors: Khonrak Thitima , Watcharadetwittaya Sasithorn , Chamgramol Yaovalux , Intarawichian Piyapharom , Deenonpoe Raksawan 
Published: April 2023

Background: Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer. The RET gene rearrangements CCDC6::RET and NCOA4::RET are the most common RET gene rearrangements in PTC patients. Different RET::PTC rearrangements are associated with different PTC phenotypes.Methods: Eighty-three formalin-fixed paraffin-embedded (FFPE) PTC samples were examined. The prevalence and expression levels of CCDC6::RET and NCOA4::RET were determined using semi-quantitative polymerase chain reaction (qRT-PCR). The association of these rearrangements with clinicopathological data was investigated.Results: The presence of CCDC6::RET rearrangement was significantly associated with the classic subtype and absence of angio/lymphatic invasion (p &lt; 0.05). While NCOA4::RET was associated with the tall-cell subtype, and presence of angio/lymphatic invasion and lymph node metastasis (p &lt; 0.05). Multivariate analysis demonstrated that an absence of extrathyroidal extension and extranodal extension were independent predictive factors for CCDC6::RET, whereas the tall-cell subtype, large tumor size, angioinvasion, lymphatic invasion and perineural invasion were independent predictive factors for NCOA4::RET (p &lt; 0.05). However, the mRNA expression level of CCDC6::RET and of NCOA4::RET were not significantly associated with clinicopathological data.Conclusion:CCDC6::RET was correlated with an innocent PTC subtype and characteristics, but NCOA4::RET correlated with an aggressive phenotype of PTC. Therefore, these RET rearrangements strongly associated with clinicopathological phenotypes and can be used as predictive markers in PTC patients.
Perencanaan Material Recovery Facility (MRF) Sampah: Studi Kasus Kelurahan Pulau Untung Jawa
Authors: Basran Basransyah , Riza Riza Hudayarizka 
Published: April 2023

Kelurahan Pulau Untung Jawa salah satu kelurahan yang ada di Kabupaten Kepulauan Seribu, DKI Jakarta. Jumlah sampah terkelola di Kelurahan Pulau Untung Jawa hanya 30%, sedangkan persentase sampah tidak terkelola sebanyak 70%. Kurang optimalnya pengelolaan sampah di Kelurahan Pulau Untung Jawa disebabkan karena terbatasnya fasilitas pengolah sampah serta minimnya kegiatan daur ulang sampah yang hanya terbatas pada pengumpulan sampah platik yang memiliki nilai ekonomi kamudian dijual ke pengepul sampah. Sampah jika tidak dikelola dengan baik dapat menjadi masalah serius bagi kelestarian lingkungan sekitar. Salah satu upaya yang dapat dilakukan untuk mengoptimalkan daur ulang sampah adalah dengan adanya fasilitas Tempat Penampungan Sampah Sementara (TPS) berbasis Material Recovery Facility (MRF). Tujuan dari penelitian ini adalah melakuan kajian terhadap jumlah timbulan dan komposisi sampah serta menghitung perencanaan luas lahan MRF. Timbulan sampah di Kelurahan Pulau Untung Jawa sebesar 14,1 m3/hari dengan densitas sampah 180 kg/m3. Komposisi sampah hasil pengukuran yaitu oraganik 54,21%, kertas 1,28%, karet 2,12%, plastik 14,64%, kaca 0,91%, kain 2,41%, logam 0,37%, nappies 2,71%, Styrofoam 2,96%, kayu 10,12%, sampah B3 0,02% dan sampah jenis lainnya 8,24%. Total kebutuhan lahan MFR pada tahun perencanaan seluas 286,3 m2. Dengan adanya MRF, jumlah sampah yang dapat didaur ulang pada tahun perencanaan sebanyak 64,96% dari total sampah yang dihasilkan atau setara 1,65 ton/hari dengan residu sampah 0,89 ton/hari.
Scenario Clustering for Long-term Hydropower-Thermal Scheduling using Shape Feature Extraction
Authors: Wang Jinghao , Yousefi Mojtaba , Rajasekharan Jayaprakash , Farahmand Hossein , Arghandeh Reza 
Published: April 2023

<p>This paper proposes an inflow scenario reduction framework applied in long-term hydro-thermal scheduling. The strategic management of limited stored hydro energy in interaction with the electricity system is defined in long-term hydro-thermal. The Scenario Fan Problem (SFP) is selected as a long-term hydro-thermal scheduling approach. This approach is suitable to represent the disaggregated physical representation of the hydro stations and captures the short-term flexibility of individual hydropower plants in the long-term scheduling. We develop a shape-based feature extraction machine learning method to capture the hydro inflow features. To highlight the performance, we compare the shape-based method with five alternative clustering methods via the validation process on a hydro-thermal test case, using in-sample and out-of-sample data analysis. Our results show that the proposed framework can significantly reduce the computational time of long-term hydro-thermal scheduling by around 90\%. Results reveal that the shape-based feature extraction performs better regarding the computational time and the expected reservoir volumes. Moreover, this study demonstrates the possibility of performing long-term hydro-thermal scheduling at a disaggregated level with detailed topology information and a small time scale. This provides more opportunities to deal with the penetration of renewable energy resources in long-term hydro-thermal scheduling.</p>
Monitoring Brushing behaviors using Toothbrush Embedded Motion-Sensors
Authors: Essalat Mahmoud , Madrid Padilla Oscar Hernan , Shetty Vivek , Pottie Gregory 
Published: April 2023

<p>Dental disease is largely preventable and closely linked to poor toothbrushing behaviors. Motion-sensors, such as accelerometers, gyroscopes, and magnetometers, allow for mon- itoring of toothbrushing behaviors. Researchers have attempted to infer tooth surface coverage using sensors attached to the toothbrush handle or embedded in smartwatches. However, the inferences may be deficient because the datasets were collected under structured toothbrushing assumptions performed in con- trolled laboratory settings and not the free-form and irregular brushing patterns observed in real-world settings. To address the aforementioned problem, we collected a dataset of 187 brush- ing sessions, including free-form brushing. We present, to our knowledge, the first motion-sensor dataset obtained during free- form brushing. Using our experiences, we discuss the challenges of studying toothbrushing behaviors in naturalistic settings. We also propose a three-stage method (i.e. pre-processing, brush transition time detection, and time-series classification) to detect the teeth surfaces brushed during a session. Our findings are two-fold: (a) the classification of teeth surfaces during free- form toothbrushing is more challenging than during brushing in controlled settings; (b) high classification accuracy can be achieved using random train-test split of the data (i.e. k-fold cross-validation); however, generalization beyond the participants in the training set poses difficulties. Beyond publishing the first dataset of free-form toothbrushing, we validate our findings by applying our proposed method to our provided dataset, as well as the datasets of toothbrushing in controlled settings. </p>
Experiments on the Generation of Higher-order Hermite-Gauss Pulses from an FM Mode-Locked Laser
Authors: Nakazawa Masataka , Yoshida Masato , Hirooka Toshihiko 
Published: April 2023

<p>We experimentally generated higher-order Hermite-Gauss (HG) pulses from an FM mode-locked laser that had a specific optical filter <em>F</em><sub><em>HG</em>m</sub>(ω) characterized by a Bessel function <em>J</em><sub><em>n</em></sub>(<em>M</em><sub><em>PM</em></sub>) and <em>A</em><sub><em>HG</em>m</sub>(ω) and <em>A</em><sub><em>HG</em>m</sub>(ω<em>+n</em>Ω<sub><em>m</em></sub>) with <em>n = </em>-∞ <em>~ </em>+∞. Here, <em>M</em><sub><em>PM</em></sub> is the phase-modulation index and <em>A</em><sub><em>HG</em>m</sub>(<em>w</em>) was the Fourier transformed spectrum of the <em>m</em>th HG pulse <em>aHG</em><sub>m</sub>(<em>t</em>) in the time domain and Ω<sub><em>m</em></sub> was the fixed angular phase-modulation frequency. The laser we constructed was a 10 GHz polarization-maintained FM mode-locked erbium fiber laser emitting at a wavelength of 1.56 μm, which included a liquid crystal on silicon (LCoS) optical device to implement the specific filter function needed to generate HG pulses. We successfully generated <em>m </em>= 0 ~ 7th HG pulses with pulse widths of 10~50 ps. For the generation of <em>m </em>= 1, 3, 5, … odd-numbered HG waveforms, the corresponding <em>F</em><sub><em>HG</em>m</sub>(ω) has no center frequency mode. Since these waveforms are odd functions in the time domain, their spectral profiles are given entirely by imaginary components with the same shape as those in the time domain. For the generation of <em>m </em>= 0, 2, 4, …even-numbered HG waveforms, the corresponding <em>F</em><sub><em>HG</em>m</sub>(ω) has a center frequency component. Since these waveforms are even functions in the time domain, their spectral profiles are given entirely by real-value components with the same shape as those in the time domain. Finally, we generated <em>m </em>= 1 ~ 3 dark and bright higher-order HG pulses by introducing a CW amplitude offset. To generate these pulses, a new bandwidth-limiting filter was installed since these pulses have a rectangular pulse component, which creates many high-frequency sidebands. </p>
Ragam Pendekatan dan Metode Penafsiran Al-Qur’an
Authors: Rifa’i Ilyas , Marlina Lina , Fauzi Safran 
Published: April 2023

Artikel ini membahas secara mendasar mengenai pendekatan dan metode yang dilakukan oleh mufassir dalam menafsirkan al-Qur’an, kelebihan dan kekurangan metode yang dipakai oleh para mufassir serta sejarah dan perkembangannya. Seiring berjalan dan berkembangnya waktu dari masa Rasulullah ﷺ hingga masa sekarang, tercatat banyak pendekatan dan metode yang dipakai oleh para mufasir diantaranya pendekatan linguistik, pendekatan berbasis logika, pendekatan berbasis tasawuf, dan pendekatan riwayat, pendekatan isyarat, sehingga dalam pembahasan metode penafsiran al-Qur’an, kita mengenal ada beberapa metode tafsir yang digunakan oleh para ulama yang menghiasi berbagai macam kitab tafsir yang terkenal dalam dunia Islam. Diantaranya metode tafsir tahlily, metode ijmaly, metode muqaran, metode kontekstual, metode tafsir bir riwayah dan metode tafsir bir ro’yi.
This article discusses fundamentally the approaches and methods used by mufassir in interpreting the Qur'an, the advantages and disadvantages of the methods used by mufassir and its history and development. As time goes on and the development of time from the time of the Prophet ﷺ to the present, there are many approaches and methods used by mufasir including linguistic approaches, logic-based approaches, Sufism-based approaches, and historical approaches, sign approaches, so that in discussing methods of interpretation of the Qur'an 'an, we know that there are several methods of interpretation used by scholars who adorn various kinds of famous commentary books in the Islamic world. Among them are the tahlily interpretation method, the ijmaly method, the muqaran method, the contextual method, the bir riwayah interpretation method and the bir ro'yi interpretation method.
Les Gilets jaunes : une révolte sans fin ?
Authors: Bernard de Raymond Antoine , Bonin Loïc , Bordiec Sylvain , Chiron Pierre , Clément Karine , Elalaoui Charif , Grémion Théo , Liochon Pauline , Ravelli Quentin , Reungoat Emmanuelle 
Published: April 2023

Partie de la contestation d’une taxe sur l’essence, la révolte des Gilets jaunes a fait preuve d’une rare longévité. Comment expliquer cet apparent paradoxe d’une révolte qui dure ? À partir d’une ethnographie comparée de 17 ronds-points répartis dans 7 départements, cet article décrit comment les formes d’occupation des ronds-points ont permis de se renouveler en changeant de nature, pour surmonter les épreuves de force locales, malgré une répression soutenue.
Usages de la blockchain dans l’innovation collaborative
Authors: Roumentcheva Sofia 
Published: April 2023

L’Internet collaboratif a révolutionné l’innovation – elle serait plus accessible, plus contributive, plus efficace. L’innovation collaborative d’un côté et la blockchain1 d’un autre en sont de parfaites illustrations. Qu’en est-il des enjeux juridiques de ces nouvelles modalités d’innovations  ? La blockchain peut-elle être une solution technique, conforme aux exigences légales2, permettant de les résoudre  ?
Diagnostic yield of bronchoalveolar lavage GeneXpert in smear-negative and sputum-scarce pulmonary tuberculosis
Authors: Koraa Emad El-Din AbdelWahab , Abdel-Fattah Eman B. , El-Touny Rana M. 
Published: April 2023

Background
Tuberculosis remains a common public health hazard in the underdeveloped world. Initial approach to diagnosis is sputum smear staining for acid-fast bacilli, however only 40% of patients are smear positive.

Aim and objectives
To assess the diagnostic yield of GeneXpert in bronchoalveolar lavage in a smear negative or sputum scarce suspected case of pulmonary tuberculosis.

Methods
This analytical cross-sectional study included 50 patients who had clinical and radiological signs consistent with pulmonary tuberculosis and three negative Ziehl–Neelsen sputum smears or unobtainable sputum. All patients underwent fiberoptic bronchoscopy guided bronchoalveolar lavage that was sent for evaluation with GeneXpert and mycobacterial culture (Löwenstein–Jensen). Sensitivity analysis was carried out using culture as the gold standard.

Results
There is a statistically significant increase of positive TB cases diagnosed by bronchoalveolar lavage GeneXpert, as all cases were positive (100%) including 17 patients that were sputum scant, while all cases diagnosed by smear acid-fast bacilli were negative (100%) (P<0.05) However, there is statistically insignificant difference of positive TB cases diagnosed by bronchoalveolar lavage GeneXpert (100%) and bronchoalveolar lavage L.J culture (100%) (P>0.05).

Conclusion
Bronchoalveolar lavage GeneXpert has superior diagnostic yield than acid-fast bacilli smear microscopy, and the yield is as effective as mycobacterial cultures, but much faster and time saving. It can be used as a gold standard for TB diagnosis.
The effect of chronic hepatitis-C virus infection on asthma control, severity, and induced sputum analysis in bronchial asthma patients
Authors: Ragab Amany , Sallam Lamiaa Ebrahim , Ali Raed E. , Besheer Tarek , Abdelrahman Manar Ahmed 
Published: April 2023

Background
Bronchial asthma is a heterogeneous disease, manifested by chronic airway-inflammatory changes. Viral hepatitis-C infection is a major worldwide illness with about 130–150 million that are chronically infected. Hepatitis-C virus (HCV) is associated with liver pathology and extrahepatic manifestations, which can lead to many indirect and direct pulmonary complications. Alteration of airway inflammation may be the underlying mechanism predisposing asthmatics with chronic HCV to more severe asthma. Discrete inflammatory types have been recognized in the sputum of asthmatics. This study aims to assess the effect of HCV infection on asthma control, asthma severity, and airway inflammation and to analyze sputum in bronchial asthma patients graded according to Global Initiative for Asthma Classification.

Patients and methods
This study included 60 adult nonsmoking asthmatic patients who were enrolled from the outpatient clinic of Chest and Tropical Departments, Mansoura University Hospital from February 2016 to September 2017. They were classified into two groups. Group A: patients without HCV infection and group B: patients with chronic HCV infection. Analysis of induced sputum to evaluate airway-inflammatory cell type in relation to asthma control, severity, and treatment step.

Results
Regarding asthma severity and treatment step, there is a significant difference between the two studied groups, while no significant differences in asthma control between the two groups were found. Successfully induced samples illustrated that airway-inflammatory cells varied in both groups; although an eosinophilic phenotype predominates in both groups, a higher percentage was present in group A (50%) than patients in group B (35%), also, paucigranulocytic phenotype was higher in group A than group B. On the other hand, the percentage of neutrophilic and mixed granulocytic phenotypes was more in group B in comparison with group A.

Conclusion
Patients with asthma and chronic HCV infection had a significant later onset of bronchial asthma, eosinophilic phenotype predominated in all asthmatic patients, especially in patients without HCV. High percentage of neutrophils was present in asthmatics with HCV infection and this suggested more severe airway inflammation.
Diagnostic value of minimum-intensity projection computed tomography chest in diagnosis of endobronchial lesions
Authors: Rezk Nasef Abd-Elsalam , Shehta Mohamed , ELmorsy Rehab , Batouty Nihal M. , MSobh Donia , Alshamy Ahmed , Algamal Mohamed 
Published: April 2023

Background
Fiberoptic bronchoscopy (FOB) is used to directly visualize the lumen of the trachea, as well as proximal and distal airways. It can be used to diagnose or treat abnormalities within or adjacent to these airways. However, it is an invasive procedure that may lead to several complications. Minimum-intensity projection (MinIP) in high-resolution computed tomography (CT) of the lungs is particularly useful because multiple lung diseases may present with reduced CT attenuation values.

Patients and methods
In this study, we included 115 patients admitted to the Chest Department, Mansoura University, Egypt. All patients were subjected to complete history taking, thorough physical examination, routine laboratory investigations, in addition to chest radiograph. CT and FOB were ordered for all cases.

Results
CT examination of the studied cases revealed mass in 43.5%, delayed resolved pneumonia in 30.4%, and collapse in 13% of cases. Furthermore, either of cavity, narrowing, or collapse was present in 4.3% of cases. Lesions were detected in the left lung in 43.5%, right lung in was 30.4%, and both lungs in 13% of cases. The sensitivity and specificity of MinIP was 69.4 and 100%, respectively, compared with FOB. The positive predictive value was 100%, whereas the negative predictive value was 71.4%, with an accuracy of 82.6%. The sensitivity of MinIP in the diagnosis was different according to the nature of the lesion. We found significant differences when comparing conventional CT with MinIP, especially in collapse, nodules, delayed resolved pneumonia, cavity, and narrowing. However, such a significant difference was not detected in the diagnosis of mass lesions.

Conclusion
We conclude that MinIP CT is a very important technique for detection of endobronchial lesion compared with conventional CT, and we recommend use of this technique when an endobronchial lesion is suspected.
Assessment of hospitalized patients with coronavirus disease 2019
Authors: Allam Amira H. , Sadek Mohamed S. , Abdellatif Mohamed A. , Gouda Tahany M. 
Published: April 2023

Introduction
Coronaviruses are a large family of viruses that lead to diseases in animals or humans.

Objective
To assess clinical, radiological, and laboratory criteria, as well as treatment of patients hospitalized with coronavirus disease 2019, and the relation to radiological progression and hospital stay.

Patients and methods
This study was a prospective observational study conducted in an isolation sector in a private hospital in Saudi Arabia. Data were obtained from electronic records.

Results
A total of 30 patients were enrolled (24 males and six females), and their mean age was 51.2±15.05 years. The presenting symptoms were fever (83.3%), cough (33.3%), shortness of breathing (26.7%), body aches (16.7%), and sore throat (10%). Chest radiograph was abnormal in 76.6%. C-reactive protein (CRP) was high at 112.59±140±0.50 mg/l, and serum ferritin was 763.21±652.18 μg/l. Lactate dehydrogenase (LDH) was higher than normal at 312.86±161 U/l. Mean D-dimer was 0.97±1.11 μg/ml. international normalized ratio was 1.09±0.194. Fibrinogen was high at 575.32±220.08 mg/dl, and activated partial thromboplastin time was 37.94±17.46 s. There was a strong positive correlation between serum ferritin and temperature, LDH, and aspartate transaminase. CRP had a strong positive correlation with alanine transaminase, total leukocytic count, lymphocytes, and neutrophil/lymphocyte ratio. Hospital stay was positively correlated with ferritin. LDH was negatively correlated with lymphocytic count. The correlation between radiological course and laboratory follow-up was poor.

Conclusion
Coronavirus disease 2019 affects males more than females and is more in elderly. Fever is a common presenting symptom. Infection affects many blood indices, such as LDH, ferritin, CRP, and fibrinogen. Radiological course of the lesions is not affected by those blood indices, whereas hospital stay is affected. The outcome is favorable in most of the patients.
The role of diaphragmatic rapid shallow breathing index and maximum inspiratory pressure in predicting outcome of weaning from mechanical ventilation
Authors: Zaytoun Tayseer M. , Elsayed Hany E. , Elghazaly Ahmed M. 
Published: April 2023

Introduction
The rapid shallow breathing index (RSBI) is considered an accurate weaning predictor. The diaphragmatic excursion (DE) and maximum inspiratory pressure (MIP) can be used as weaning parameters. Substitution of the tidal volume by the DE in the RSBI, that is, calculating the diaphragmatic RSBI (DRSBI, RR/DE), might yield a more precise weaning predictor.

Objective
The aim of this research was to evaluate the predictive value of the DRSBI, MIP, and the ratio between them (MIP/DRSBI) in the weaning of mechanically ventilated patients.

Patients and methods
In our study, 64 mechanically ventilated patients were enrolled. At the time of their first spontaneous breathing trial, ultrasonographic assessment of the DE was done, MIP was measured, and RSBI, DRSBI, and MIP/DRSBI were calculated. A total of 36 (56.25%) patients had successful weaning, whereas 28 (43.75%) failed the weaning trial. The new composite parameter (MIP/DRSBI) with a cutoff value greater than or equal to 17 cmH2O/min/mm/breath was the best tool to predict successful weaning with area under the receiver operating characteristics curve of 0.982, with sensitivity and specificity of 100 and 96%, respectively.

Conclusion
Combining the MIP and DRSBI in one composite parameter (MIP/DRSBI) improved the sensitivity, specificity, and accuracy of both parameters when compared with either parameter alone.