bluuebunny/crossref_metadata_2025_split huggingface dataset:
Validation of a Multidisciplinary Virtual Reality (VR) Robotic Surgical Curriculum
Authors: Kim Jessica S , Jonas Nicholas , Rizvi Tasneem Zaihra , Lin Zhibang , Plewa Deanna , Ricard Caroline , Cheah Yee Lee , Simon Caroline , Wright Valena 
Published: June 2023

Abstract
Objective: To identify whether trainees demonstrate improvement in a standardized knot-tying task as assessed by Global Evaluative Assessment of Robotic Skills (GEARS) score after completion of a virtual reality (VR) robotic curriculum.
Design: An IRB-exempt prospective study conducted with surgical trainees from August 2021 – February 2023. Participants initially performed a baseline robotic suturing task in which they were instructed to tie interrupted square knots in 10 minutes. Participants then completed a virtual reality simulation curriculum involving 23 exercises until they achieved 90% proficiency on all tasks. Participants then repeated the suturing task. Pre- and post- curriculum suturing tasks were recorded, de-identified, and scored by expert graders using a GEARS score.
Setting: Trainees from three academic centers were invited to participate.
Participants: Medical students (MS1-MS3) and surgical residents from gynecology, urology, and general surgery were invited to participate.
Results: 25 trainees completed the pre-curriculum suturing task, the VR curriculum, and the post-curriculum suturing task. Trainees demonstrated significant improvement in their post-test GEARS score by 2.43 points (95% CI 1.19 - 3.66, p<0.05) and were able to tie three additional knots within 10 minutes after completion of the curriculum (95% CI 1.54 - 3.58, p<0.05). Trainees also demonstrated a faster time to complete first knot (129.24 second improvement, 95% CI 65.66 - 192.82, p<0.05) after completion of the curriculum. PGY3 trainees were able to tie more knots prior to the curriculum as compared to PGY1 trainees and medical students (p<0.05), but this difference was no longer significant after all groups completed the curriculum (p=0.04).
Conclusion: Surgical trainees and medical students with limited prior robotic surgical experience demonstrated objective improvement after completion of a standardized VR curriculum.
Prognostic Factors for Surgical Management of Ipsilateral Femoral Neck and Shaft Fractures
Authors: Yang Lixin , Sun Tao , Liu Jianning , Li Xu , Guo Jichao , Li Sheng , Qi Dongxu , Wang Wei 
Published: June 2023

Abstract
Background
The aim of this study is to determine the risk factors affecting postoperative function of ipsilateral femoral neck and shaft fracture.
Methods
From January 2014 to December 2020, patients with ipsilateral femur neck and shaft fractures were enrolled in this study. All of the patients underwent surgical treatment, and the date of the preoperative and 2-year follow-up were analyzed. The functional results were evaluated according to Freidman and Wyman functional criteria. Associations between clinical variables and function of postoperative were examined in univariate and multivariate analysis.
Results
Of all the 53 patients, 39 patients (73.6%) had good or fair functional recovery, while 14 patients (26.4%) had bad functional recovery. Univariate analysis showed that age, BMI (body mass index), internal fixation method, osteoporosis, intraoperative bleeding and deep venous thrombosis (DVT) were related with functional recovery. Binary logistic regression analysis showed that internal fixation method, BMI and DVT were independently associated with the functional recovery of patients 2 years after surgery.
Conclusions
This study found that the use of reconstruction nailing was a favorable prognostic factor, while obesity and DVT are adverse factors for ipsilateral femoral neck and shaft fractures, which may provide reliable reference for orthopedic surgeons.
NMTHC: a hybrid error correction method using a machine translation model based on the sequence-to-sequence framework
Authors: Wang Rongshu , Chen Jianhua , Lu Zhiwen 
Published: June 2023

Abstract
Background
With the development of sequencing technology, the reads produced by third-generation sequencing technologies have ultra-long lengths and cost-effectiveness and have drawn the favor of many application scenes. However, compared with the shorter reads obtained by next-generation sequencing, the high error rates of these long reads affect the accuracy in downstream analysis.
Results
In this work, a novel hybrid error correction algorithm (NMTHC) based on the sequence-to-sequence framework is proposed, which converts the long-read error correction problem into a machine translation problem in natural language processing. First, the high-precision short reads are aligned to the long reads to generate alignment information, and then the long reads and alignment information are tokenized to generate “long sentences” and “target sentences”. The generated sequences are padded to the same length and then divided into batches for training. Both the encoding and the decoding layer of the model use the bidirectional Long Short-term Memory (Bi-LSTM) network to encode and decode hidden state information, and the generated token and the updated state at the current time step are used to predict the token of the next time step.
Conclusions
We have tested our algorithm on subsets of long reads, and the results show that NMTHC is not only excellent in the number of aligned bases with the reference genome but also improves the alignment identity without any loss of the read length. In addition, it has been proved that NMTHC can be distributed in multiple GPUs to improve the correction speed. In summary, NMTHC can correct long reads more accurately while keeping read length and continuity. It can be applied to sequencing data from both mainstream platforms and provides a new perspective for hybrid error correction algorithms based on deep learning.
Pathology of knee osteoarthritis pain: contribution of joint structural changes and pain sensitization to movement-evoked pain in knee osteoarthritis
Authors: Hattori Takafumi , Ohga Satoshi , Shimo Kazuhiro , Matsubara Takako 
Published: June 2023

Abstract
Movement-evoked pain (MEP) is the primary symptom in patients with knee osteoarthritis (KOA). This study aimed to investigate the contribution of joint structural changes and pain sensitization to the mechanisms of MEP in KOA. A total of 86 patients were assessed for demographic characteristics, osteoarthritis severity, Whole-Organ Magnetic Resonance Imaging Score – Hoffa synovitis and bone marrow lesions, pressure pain threshold and temporal summation of pain at the knee and forearm, Central Sensitization Inventory-9, and MEP. Knee pain was scored using a numerical rating scale (NRS, 0–100) before and every minute during a 6-min walking test (6MWT), and the MEP index was defined as the change in NRS pain score from baseline to the 6th minute of walking. On average, pain during 6MWT increased by 14.4 ± 15.5 points on the NRS relative to baseline, with 30.2% of patients showing an increase of 20 points or more. The hierarchical linear regression analysis revealed that Hoffa synovitis and temporal summation of pain at the knee were associated with the MEP index. The findings of this study suggest that both joint pathology, such as synovitis, and neural mechanisms, such as central sensitization, play a role in the development of MEP in KOA.
Carbon and oxygen isotope characteristics of carbonate rocks in the Mesoproterozoic Jixian System of the Ordos Basin and their implications
Authors: Xiaofeng Liu , Zenglin Hong , Jiwei Liang , Xiaodan Guo , Xue Xueping , Li Shifeng 
Published: June 2023

Abstract
The paleoenvironment of Jixian carbonate rocks in the Mesoproterozoic Ordos Basin is studied by carbon and oxygen isotope analysis, diagenetic environment analysis, and restoration of paleosalinity and paleotemperature. The results indicate that the carbonate rocks of the Jixian System have always been in a near surface environment and have not been deeply buried, the variation range of d 13CPDB and d18OPDB is relatively narrow, ranging from -5.75 ‰ to 1.41 ‰ and -8.88 ‰ to -4.01 ‰, respectively, which is consistent with the stable tidal flat sedimentary environment during the Mesoproterozoic in the study area. The paleosalinity (Z) ranges from 111.7 to 127.1, and the paleotemperature (T) ranges from 32.71℃ to 57.33 ℃, indicating a relatively warm paleoclimatic environment during the Mesoproterozoic period in the study area. Analysis shows that in a warm paleoclimatic environment, although carbon and oxygen isotopes, Z, and T have certain fluctuations, their range is relatively small, reflecting to some extent the stable tectonic environment of the study area during the Mesoproterozoic period. Comprehensive research shows that the Ordos Basin had a warm climate and a stable tectonic environment in the Mesoproterozoic, which may be a good response to the North China Block's position near the equator and continuous thermal subsidence in the Mesoproterozoic.
Effects of an early transfer from incubator to a warming crib in very low birthweight preterm infants
Authors: Greve Sandra , Bruns Nora , Dathe Anne-Kathrin , Schuendeln Michael , Felderhoff-Müser Ursula , Stein Anja 
Published: June 2023

Abstract
Purpose: Very low birth weight infants are cared for postnatally in the incubator because of adverse consequences of hypothermia. Data on the optimal weight of transfer to a warming crib are rare. The aim of this study was to determine the course of temperature and body weight during a standardized transfer to a warming crib at a set weight.
Methods: Prospective intervention study in very low birthweight infants who were transferred from the incubator to a warming crib at a current weight between 1500g and 1650g.
Results: No infant had to be transferred back to an incubator. Length of hospital stay was equal compared to a historical cohort from the two years directly before the intervention. The intervention group showed an increase in the volume fed orally on the day after transfer to the warming crib, although this did not translate into an earlier discontinuation of gavage feedings. Compared to the historical group, infants in the intervention group could be transferred to an unheated crib at an earlier postmenstrual age and weight.
Conclusions: Early transfer from the incubator to a warming crib between 1500 g and 1650 g is feasible and not associated with adverse short-term events or outcomes.
Tag-SNPs identification in Gaddi dogs in the light of divergent canine breeds
Authors: Kaur Bhawanpreet , Mahajan SK , Mukhopadhyay Chandra Sekhar 
Published: June 2023

Abstract
The present research proposal was designed to explore the tag-SNPs in indigenous Gaddi dogs concerning other popular dog breeds maintained in India and to determine the genome-wide distributed SNPs, haplotype and linkage disequilibrium (LD). In this study, ddRAD-GBS custom sequencing was done using Illumina 150 bp paired-end sequencing of fifty dog samples. A total of 3,56,461 SNPs loci were screened, out of which 75811 high-quality SNPs were screened. Linkage disequilibrium (LD), Haplotype analysis, and tag-SNP identified using pipelines based on Linux using bash. sed and awk coding, R-environment. The cataloging of the tag-SNPs associated with underlying different pathways and the validation of selected genes based on Th1 (IL-2, TNF-alpha), Th2-biased pathways (IL-10), and diseases-associated (CDK2, TTC8) using q-real-time PCR. The results indicated about 2033 tag-SNPs were found to be statistically significant (P < 0.000001) and cataloged the associated genes. The relative expression of genes was expressed in both groups. The IL-10 gene shows significant difference between the two groups (P < 0.05). The findings provide important information for future allele/gene identification using genome-wide association studies (GWAS) for dog-breeding programs. This is the maiden report on tag-SNPs and the population structure of the Indian dog breeds (Gaddi & Mudhol Hound) at the molecular level.
Responses of Coastal Wetlands to Rising Sea-Level Revisited: The Importance of Organic Production
Authors: Morris James T , Sundberg Karen 
Published: June 2023

Abstract
A network of 15 Surface Elevation Tables (SET) at North Inlet estuary, SC, have been monitored on annual or monthly time scales beginning from 1990 to 1996. The initial elevations spanned a range from suboptimal to superoptimal relative to the vertical growth range of the dominant vegetation, Spartina alterniflora. Of 98 time series, 20 have elevation gains equal to or exceeding the local rate of sea-level rise (SLR, 0.34 cm/yr). The elevation gain in North Inlet is dominated by organic production and, we hypothesize, is proportional to net ecosystem production. The rate of elevation change was 0.47 cm/yr in plots experimentally fertilized for 10 years with N&P compared to nearby control plots that have gained 0.1 cm/yr in 26 yr. The excess gains and losses of elevation in fertilized plots are accounted for by changes in belowground biomass and turnover. This is supported by bioassay experiments in marsh organs where in 3 years the belowground biomass of fertilized S. alterniflora plants increased by 1,772 g m-2 yr-1, which is equivalent to 2.1 cm/yr. Root biomass was greater in the fertilized treatment than in controls, but in both treatments, roots plateaued at about 973 g m-2 and 613 g m-2, respectively. Growth of belowground biomass was dominated by rhizomes, which continued to grow at a rate of 1,227 g m-2 yr-1 in the fertilized treatment after 3 years. Wetlands like North Inlet could be classified as autonomous because they depend on in situ organic production to maintain elevation. Autonomous wetlands are more vulnerable to SLR because their elevation gains are limited by net ecosystem production whereas minerotrophic wetlands are limited ultimately only by the mineral sediment supply.
Optically Transparent Microstrip Feed Lens Antenna for 6G Wireless Backhaul Communication
Authors: P Jeyakumar , S Saranya , K Sachin Aravinth , PS Praveen Anandh , P Muthuchidambaranathan 
Published: June 2023

Abstract
The demand for high-data-rate communication services in 5G and 6G wireless communication systems has led to an increasing need for mounting multiple access points and base stations. However, the proliferation of these infrastructure elements can result in a cluttered and visually unappealing environment. To address this issue, optically transparent antennas (OTAs) offer an ideal solution by maintaining device aesthetics while fulfilling coverage and bandwidth requirements. In this work, initially link budget analysis for deployment of wireless backhaul communication system with target data rate of 100 Gbps. Then, we have designed microstrip fed with lens antenna for operating the frequency of 300GHz.These antennas were designed and simulated using the High Frequency Structure Simulator (HFSS) with transparent quartz glass as the substrate and graphene as the patch material. To obtain a high-directional beam, a hollow hemispherical lens made of lead sil-icate was used. By using a lens, the gain is increased by about 50%, i.e., 9.63 dB, when compared to the normal antenna gain of 6.13 dB.
Statistical de Rham Hodge operators and general Kastler-Kalau-Walze type theorems for manifolds with boundary
Authors: Li Hongfeng , Wu Tong , Wang Yong 
Published: June 2023

Abstract
In this paper, we establish some general Kastler-Kalau-Walze type theorems for any dimensional manifolds with boundary which generalize the results in [S. Wei, Y. Wang, Statistical de Rham Hodge operators and the Kastler-Kalau-Walze type theorem for manifolds with boundary. J. Nonlinear Math. Phys. 28(2), 254-275, (2021)].
The study of antistaphylococcal potential of Omiganan and retro-Omiganan under flow conditions
Authors: Jaśkiewicz Maciej , Neubauer Damian , Sikora Karol , Bauer Marta , Bartoszewska Sylwia , Błażewicz Izabela , Marek Dariusz , Barańska-Rybak Wioletta , Kamysz Wojciech 
Published: June 2023

Abstract
Staphylococcus aureus is considered as one of the leading pathogens responsible for infections in humans and animals. The heterogeneous nature of diseases caused by these bacteria is due to occurrence of multiple strains, differentiated by several mechanisms of antibiotic resistance and virulence factors. One of these is the ability to form biofilm. Biofilm-associated bacteria exhibit a different phenotype that protects them from external factors such as activity of immune system or antimicrobial substances. Moreover, it was shown that in majority of persistent and recurrent infections is associated with the presence of the biofilm. Antimicrobial peptides (AMPs) are compounds widely distributed in nature as a key component of non-specific immunity of organisms with a wide spectrum of antimicrobial activity. Their amino acid-based structure as well as approaches of chemical synthesis indicate that AMPs provide an excellent matrix for the development of new antimicrobials. Omiganan an analog of Indolicidin, is a peptide derived from bovine neutrophil granules which was found to exhibit high antistaphylococcal and antibiofilm potential. Furthermore, its analog with a reversed sequence (retro-Omiganan) was found to display enhanced activity against a variety of pathogens. The aim of this study was to investigate the activity of both compounds against S. aureus biofilm under flow conditions. The advantage of this approach was that it offered the opportunity to form and characterize the biofilm under more controlled conditions. To do this, unique flow cells made of polydimethylsiloxane (PDMS) were developed. The activity against pre-formed biofilm as well AMPs-treated bacteria was measured. Also, incorporation of Omiganan and retro-Omiganan into the channels was conducted to learn whether or not it would inhibit the development of biofilm. The results of the microbiological tests ultimately confirmed the high potential of the Omiganan and its retro analog. Moreover, the developed methodology allows implementation of the studies under flow conditions to other compounds.
Agreement on actions to be taken and their respective importance in the assessment, treatment and follow-up of phlebitis secondary to peripheral venous catheterisation: a Delphi study at national level in Spain
Authors: Torné-Ruiz Alba , Reguant Mercedes , Sanromà-Ortiz Montse , Piriz Marta , García-Expósito Judith , Roca Judith 
Published: June 2023

Abstract
The authors have requested that this preprint be removed from Research Square.
Effect of tetrabromobisphenol A (TBBPA) on early implantation using the three-dimensional spheroid model with human endometrial cell line, Ishikawa
Authors: KOO Myoungjoo , KANG Inyoung , JUN Jin Hyun , Lee Jaewang 
Published: June 2023

Abstract
Background
Tetrabromobisphenol A (TBBPA) has endocrine-disrupting effect and has been widely used as brominated flame retardant in industrial products. The endocrine-disrupting chemical has effects on female reproduction such as infertility, hormone imbalance, and endometriosis. In Korea, the problems of infertility and the decreasing birth rate are concerns. Exposure to EDCs might have a harmful effect on childbearing-age women. This study aimed to investigate the effect of TBBPA on infertility, particularly on uterus endometrium early implantation events.
Results
The expression of mRNA was analyzed by qRT-PCR. The mRNA expression of TBBPA on Ishikawa cells, IL-6, IL-1β, TNF- α, and LIF were significantly increased. Moreover, the outgrowth area in the TBBPA group has significantly decreased compared with the control. On the other hand, TBBPA had a slight effect on protein level and attachment rate.
Conclusions
In this study, TBBPA occurred inflammatory environmental milieu in mRNA expression. The increase of inflammation-related cytokines in the endometrium can disrupt the implantation of the embryo. Also, the TBBPA disrupted the outgrowth of spheroids on the endometrium, however, the protein levels and attachment rate were comparable to the control group. The effect of TBBPA on implantation events should be further clarified.
Return to work after cancer–the impact of working conditions: A Norwegian Register-based Study.
Authors: Le Giang Huong , Hermansen Åsmund , Dahl Espen 
Published: June 2023

Abstract
Purpose
The purpose of this project is to compare a cohort of cancer survivors with a cohort of cancer-free employees (1) with respect to employment prospects over a 15-year period and (2) with respect to the differential impact of working conditions on employment over this time period.
Methods
The cancer cohort is retrieved from the Cancer Registry of Norway, while data on the non-cancer cohort are retrieved from register data managed by Statistics Norway. Job exposure matrices were used to remedy the lack of working-conditions information in the register data. We use nearest-neighbor matching to match the non-cancer cohort (the control group) to the cancer-survivor cohort (the treatment group). Cox regression analysis was applied to examine the relationships between working conditions, employment, and cancer. The results are reported separately for mechanical-job exposure and psychosocial exposure, as well as by gender.
Results
Cancer survivors are more likely to experience reduced employment as compared to individuals without a history of cancer. Male cancer survivors in physically demanding occupations have an increased risk of reduced employment after being diagnosed with cancer. This does not apply to female cancer survivors. Regarding the impact of psychosocial exposures on employment, we find no differences over time between cancer survivors and the non-cancer population.
Conclusions
Male cancer survivors in physically demanding occupations have an increased risk of reduced employment after being diagnosed with cancer, whereas this is not the case for female cancer survivors. Psychosocial exposures do not impact the relative risk of reduced employment over time.
Implications for cancer survivors:
We suggest that return to work after cancer should be considered a process rather than only the re-entry step of resuming work. Thus, it is important to provide long-term support for cancer survivors. We recommend providing more attention to working conditions, particularly in occupations that involve a high level of mechanical-job exposure.