bluuebunny/crossref_metadata_2025_split huggingface dataset:
The protobranch Aequiyoldia eightsii (Jay, 1839) (Nuculanida: Sareptidae) reveals uncommon siphonal anatomy among bivalves
Authors: Batistão A R , Audino J A , Passos F D 
Published: July 2023

ABSTRACT
Siphons represent a remarkable example of evolutionary convergence in different bivalve lineages. In Protobranchia, the siphons, when present, are used exclusively to channel the water currents used for respiration, waste removal and gamete release. Their emergence is thought to be associated with the taxonomic and morphological diversification within the Nuculanida. While siphons have been extensively studied in other bivalve groups, particularly the Heterodonta, gaps remain in the knowledge of protobranch siphons, especially on their morphology, including the musculature and innervation, and their functioning. The few data on Protobranchia siphons are restricted to some Nuculanoidea, and information is still missing for other nuculanid lineages, such as the Sareptoidea. The present study provides a description of the siphonal morphology of Aequiyoldia eightsii, a sareptid bivalve. Histological data were obtained to investigate their organization and infer their functioning. All traits observed were compared with those of heterodont siphons. In A. eightsii, the siphons are fused with each other and distinguished by their reduced longitudinal musculature in bundles that do not form layers, by the presence of a blood lacunal system that fills most of the wall of the siphon and by the innervation that is likely diffuse. This suggests that the siphons are hydrostatic organs with a hydraulic mechanism whose expansion occurs when the lacunar system is filled with blood. Our results provide the first morphological and functional details of a protobranch siphon and thus contribute to knowledge on the comparative anatomy of Bivalvia.
Impact of Anti-EGFR Therapies on HER2-Positive Metastatic Colorectal Cancer: A Systematic Literature Review and Meta-Analysis of Clinical Outcomes
Authors: Bekaii-Saab Tanios S , Lach Krzysztof , Hsu Ling-I , Siadak Muriel , Stecher Mike , Ward James , Beckerman Rachel , Strickler John H 
Published: July 2023

AbstractBackgroundHER2 overexpression/amplification in patients with RAS wild-type (WT) metastatic colorectal cancer (mCRC) may be associated with resistance to standard-of-care anti-EGFR therapies. Given the lack of comprehensive investigations into this association, we assessed the prognostic or predictive effect of HER2 amplification/overexpression on anti-EGFR treatment outcomes.MethodsA systematic review of MEDLINE, Embase, and Cochrane Library (2001-2021) identified studies evaluating progression-free survival (PFS), overall response rate (ORR), and overall survival (OS) in HER2-positive vs. HER2-negative patients with RAS WT mCRC who received anti-EGFR treatments and whose HER2 status was known. Meta-analyses of proportions (ORR) and hazard ratios (PFS, OS) were performed using random-effect models with pre-specified sensitivity analyses.ResultsFive high-quality retrospective cohort studies were included in the meta-analyses representing 594 patients with mCRC. All patients received anti-EGFR treatment, either as monotherapy or in combination with chemotherapy. Meta-analysis of PFS demonstrated a 2.84-fold higher risk of death or progression (95% CI, 1.44-5.60) in patients with HER2-positive (vs. HER2-negative) RAS WT mCRC treated with anti-EGFR regimens. The odds of response to anti-EGFR treatment were 2-fold higher in HER2-negative vs. HER2-positive (odds ratio, 1.96 [95% CI, 1.10-3.48]). Differences in OS were not statistically significant. Sensitivity analyses confirmed the robustness of the base-case estimates.ConclusionsWhile this study could not account for all confounding factors, in patients with RAS WT mCRC who received anti-EGFR therapy, HER2 overexpression/amplification was associated with worse PFS and ORR and may therefore predict poorer outcomes. HER2 testing is important to inform treatment decisions and could optimize outcomes for patients.
XIIIThe Victorian Period
Authors: Garza Ana Alicia , Snailham Fiona , Blackburn-Daniels Sally , Zarif Mariam , Baker William 
Published: July 2023

AbstractThis chapter has five sections: 1. General and Prose, including Dickens; 2. The Novel; 3. Poetry; 4. Periodicals, Publishing History, and Drama; 5. Miscellaneous and Drama. Section 1 is by Ana Alicia Garza; section 2 is by Fiona Snailham; section 3 is by Sally Blackburn-Daniels; section 4 is by Mariam Zarif; section 5 is by William Baker, who thanks for their assistance Dominic Edwards, Brent E. Kinser, Marcus Neacey, Jean Saunders, and Patrick Scott.
The mGlu2/3 agonist LY379268 reduces sucrose taking, seeking, and motivation in male and female rats
Authors: Grimm Jeffrey William , Sauter Frances , MacDougall Derek , Spaulding Emily , Stensgaard Kyra , Hardy Mason , Griffin Kyle , Marx Rebecca 
Published: July 2023

Objectives
The mGlu2/3 receptor agonist LY379268 reduces sucrose-seeking, but not sucrose-taking, in male rats. This study explored the generality of this effect across the sexes. In addition, the effect of the drug on motivation to receive sucrose was assessed.

Methods
Adult male and female Long-Evans rats (N = 91) were challenged with LY379268 in three experiments: (1) a fixed ratio (FR) schedule of reinforcement (taking), (2) extinction of responding previously reinforced on the FR (seeking) or (3) responding reinforced on a progressive ratio (PR) schedule of reinforcement (motivation). For each experiment, rats first responded to 10% liquid sucrose on an FR in 10 daily 2-h sessions. For the PR study, this was followed by training on a PR for 7 daily 3-h sessions. Rats were then challenged in a counterbalanced order with LY379268 (0, 1.5, 3 and 6 mg/kg; IP; 30-min pretreatment) on test days, followed by either three reacquisition days of FR (experiments 1 and 2) or PR (experiment 3) responding.

Results
Female rats responded more to sucrose on the FR and PR. LY379268 reduced responding in all three experiments. LY379268 challenge to sucrose taking on the FR produced an inverted U-shaped function while extinction responding and responding for sucrose on the PR were decreased dose-dependently, with PR responding insensitive to the 1.5 mg/kg dose. There were no sex-dependent effects of the drug on sucrose-directed responding.

Conclusions
The sucrose anti-taking, -seeking, and -motivation effects of LY379268 across male and female rats support further evaluation of glutamate modulation as an antiaddiction pharmacotherapy.
HYPERACUTE CUTIBACTERIUM ACNES ENDOPHTHALMITIS AFTER CATARACT SURGERY
Authors: Hauser Blake M. , Hoyek Sandra , Greenstein Scott H. , Patel Nimesh A. 
Published: July 2023

Purpose:
Postoperative endophthalmitis is a relatively uncommon, but potentially visually devastating, complication associated with cataract surgery. Specific microbial causes of endophthalmitis are characteristically associated with particular disease time courses. Although Cutibacterium acnes is typically associated with an indolent course of inflammation, we report a case of C. acnes endophthalmitis with onset on postoperative day (POD) 1 and a positive culture from POD 2.

Methods:
This is a case report.

Results:
A 56-year-old man underwent cataract extraction and posterior chamber intraocular lens placement in his left eye. On POD 1, he presented with severe discomfort, reduced visual acuity, and significant inflammation. On POD 2, his anterior chamber was tapped and injected with broad-spectrum antibiotics and steroids. The inflammation ultimately resolved, and his visual acuity improved to 20/20.

Conclusion:

C. acnes is a rare cause of hyperacute-onset postoperative endophthalmitis. Maintaining a high clinical suspicion and initiating prompt treatment can help to optimize long-term visual outcomes.
Updates in the diagnosis and management of chronic thromboembolic disease
Authors: Kabadi Alisha , Kerr Kim , Fernandes Timothy M. 
Published: July 2023

Purpose of reviewChronic thromboembolic disease (CTED) is distinct from chronic thromboembolic pulmonary hypertension (CTEPH) and is defined by dyspnea on exertion after acute pulmonary embolism with the presence of residual perfusion defects and absence of resting pulmonary hypertension. Here, we review clinical features and diagnostic criteria for CTED and summarize treatment options.Recent findingsThe optimal management for CTED is unclear as the long-term outcomes of conservative vs. invasive treatment for this disease have not been reported. There are a few studies evaluating outcomes of pulmonary thromboendarterectomy and balloon pulmonary angioplasty (BPA) in CTED, concluding that these procedures are safe and effective in select patients. However, these trials are small nonrandomized observational studies, reporting outcomes only up to 1 year after the intervention. Conservative management of CTED with observation, pulmonary hypertension-targeted therapy, or cardiopulmonary rehabilitation has not been studied. It is unknown whether these treatments are as effective or superior to pulmonary thromboendarterectomy or BPA in CTED.SummaryThe management of CTED is individualized and based on symptoms and exercise limitations. Early referral of patients with CTED to a specialized CTEPH center is recommended to determine if watchful waiting, BPA, or pulmonary thromboendarterectomy is most beneficial.
Visual impact beam plots: Analyzing research profiles and bibliometric metrics using the following-leading clustering algorithm (FLCA)
Authors: Cheng Yung-Ze , Chien Tsair-Wei , Ho Sam Yu-Chieh , Chou Willy 
Published: July 2023

Background:
A new approach to showcasing author publications on a website involves using a visual representation instead of the conventional paper list. The creation of an impact beam plot (IBP) as a research profile for individuals is crucial, especially when incorporating collection edges that include self-cited articles through a rare cluster analysis technique not commonly found in the literature. This study presents the application of a unique method called the following-leading clustering algorithm (FLCA) to generate IBPs for 3 highly productive authors.

Methods:
For the 3 highly productive authors, Sung-Ho Jang from South Korea, Chia-Hung Kao from Taiwan, and Chin-Hsiao Tseng from Taiwan, all their published articles indexed in the Web of Science Core Collection were downloaded. Sung-Ho Jang published 593 articles, Chia-Hung Kao published 732 articles, and Chin-Hsiao Tseng published 160 articles. To analyze and showcase their publications, the FLCA was utilized. This algorithm helped cluster their articles and identify representative publications for each author. To assess the effectiveness and validity of the FLCA algorithm, both network charts and heatmaps with dendrograms were employed. IBPs were then created and compared for each of the 3 authors, taking into consideration their h-index, x-index, and self-citation rate. This allowed for a comprehensive visual representation of their research impact and citation patterns.

Results:
The results show that these authors’ h-index, x-index, and self-citation rates were (37, 44.01, 1.66%), (42, 61.47, 0.23%), and (37, 40.3, 6.62%), respectively. A higher value in these metrics indicates a more remarkable research achievement. A higher self-citation rate with a lower cluster number indicates that manuscripts are more likely to have been self-drafted. Using the FLCA algorithm, IBPs were successfully generated for each author.

Conclusion:
The FLCA algorithm allows for the easy generation of visual IBPs based on authors’ publication profiles. These IBPs incorporate 3 important bibliometric metrics: h-index, x-index, and self-citations. These metrics are highly recommended for use by researchers globally, particularly with the self-citation rate, as they offer valuable insights into the scholarly impact and citation patterns of individual researchers.
Avoidant restrictive food intake disorder and pediatric feeding disorder: the pediatric gastroenterology perspective
Authors: Noel Richard J. 
Published: July 2023

Purpose of review
Avoidant/restrictive food intake disorder (ARFID) and pediatric feeding disorder (PFD) are the newest evolutions of frameworks for dysfunctional feeding and share overlapping features but maintain notable differences. This review will compare the two frameworks, highlighting some of the latest advances in diagnosis and management.

Recent findings
Dysfunctional feeding, particularly withing the PFD definition, benefits from multidisciplinary care with equal attention to medical, nutritional, skill-based, and behavioral domains. Management requires medical attention, often with functional gastrointestinal disease and anxiety. Pharmacologic appetite stimulation may play a role. A single empirically proved behavioral approach has not been described and multiple options exist regarding type, location, and intensity of feeding therapy.

Summary
ARFID and PFD not only share areas of overlap, but also differ, likely based on the origins of each framework. Ultimately, both frameworks describe dysfunctional feeding and require input from medical providers. The more effective approaches tend to be multidisciplinary, addressing medical, nutritional, skill-based, and/or behavioral aspects of the disorder (the PFD model). Future evolution of both ARFID and PFD frameworks is likely to generate refinement in their defining criteria, hopefully generating a structured link between the two.
Counter-conducting environmental injustices and (un)accountability: Ken Saro-Wiwa’s accounts of the Ogoni’s struggle for emancipation
Authors: Lauwo Sarah George , Egbon Osamuyimen , Denedo Mercy , Ejiogu Amanze Rajesh 
Published: July 2023

PurposeThis paper explores the historical roots of environmental accountability in the Niger Delta region of Nigeria by focusing on the campaigns for social and environmental justice by writer Ken Saro-Wiwa and the indigenous Ogoni people.Design/methodology/approachThe methods consist of an analysis of books, diaries, letters and poems written by Ken Saro-Wiwa as well as books, reports and audio recordings of panel discussions which capture the Ogoni struggle, Ken Saro-Wiwa’s activism and its impacts. The authors’ approach to the data is sensitised by Foucault’s notion of counter-conduct as it enables the authors to better grasp the creative agency of Saro-Wiwa and the Ogoni as they struggle and campaign for political autonomy, environmental justice and accountability.FindingsThe authors’ findings illustrate how Ken Saro-Wiwa’s books, letters, poems, diaries and articles provide early accounts of environmental injustices and the absence of accountability in the Niger Delta. They highlight how Saro-Wiwa and the Ogoni movement deploy counter-conduct to subvert existing power and accountability structures through innovative strategies, effective mobilisation and communication at local and international levels. The authors’ findings also highlight how these have led to specific forms of accountability for human rights and the environment at local and global levels. They also show how Saro-Wiwa’s activism and the Ogoni struggle have inspired a new generation of environmental activists and new ways of demanding accountability.Originality/valueThis paper presents, for the first time, an account of the historical roots of environmental accountability practices from an African and developing country context. Its focus on the historical roots of environmental accountability is also unique as it expands the view beyond the origins of environmental accounting to look more broadly at the origins of environmental accountability practices.
Ileostomy versus colostomy: impact on functional outcomes after total mesorectal excision for rectal cancer
Authors: Martellucci Jacopo , Balestri Riccardo , Brusciano Luigi , Iacopini Veronica , Puccini Marco , Docimo Ludovico , Cianchi Fabio , Buccianti Piero , Prosperi Paolo 
Published: July 2023

AbstractAimEven if a defunctioning stoma mitigates the serious consequences of anastomotic leakage after total mesorectal excision (TME) for rectal cancer, the presence of a temporary stoma or having a stoma for a prolonged period of time may also be a determining factor for further morbidities and poor bowel function. The aim of this study was to evaluate the impact of diverting stomas on clinical and functional outcomes after TME, comparing ileostomy or colostomy effects.MethodsAll consecutive patients who underwent TME for rectal cancer between March 2017 and December 2020 in three Italian referral centres were enrolled in the present study. For every patient sex, age, stage of the tumour, neoadjuvant therapy, surgical technique, anastomotic technique, the presence of a diverting stoma, perioperative complications and functional postoperative status were recorded. Considering the diverting stoma, the kind of stoma, length of time before closure and stoma related complications were evaluated.ResultsDuring the study period 416 consecutive patients (63% men) were included. Preoperative neoadjuvant therapy was performed in 79%. A minimally invasive approach was performed in >95% of patients. Temporary stoma was performed during the operation in 387 patients (93%) (ileostomy 71%, colostomy 21%). The stoma was closed in 84% of patients. The median time from surgery to stoma closure was 145 days. No difference was found between ileostomy and colostomy in overall morbidity after stoma creation and closure. Moreover, increased postoperative functional disturbance seemed to be significantly proportional to the attending time for closure for ileostomy.ConclusionThe presence of a defunctioning stoma seems to have a negative impact on functional bowel activity, especially for delayed closure for ileostomy. This should be considered when the kind of stoma (ileostomy vs. colostomy) is selected for each patient.
Servitisation of SMEs through strategic alliances: The role of intellectual capital
Authors: Rapaccini Mario , Cinquini Lino , Mauro Sara Giovanna , Tenucci Andrea 
Published: July 2023

AbstractThis research sought to uncover the role played by intellectual capital (IC) in the interplay between strategic alliances of small‐ and medium‐sized enterprises (SMEs) and servitisation strategies. An in‐depth investigation of a single case represented by an SME consortium in the elevator industry served as the empirical context. Multiple sets of data were examined by integrating the analysis of documents with the analysis of data gathered through semi‐structured interviews. We found that a strategic alliance among SMEs constitutes a form of relational capital and creates/improves other components of IC that support the formulation of the servitisation strategy and enable its implementation. The development of IC triggered by the formation of a strategic alliance appears to function as a driver of the servitisation strategy and to influence the innovation process. The value of this research lies in the analysis of IC in a new context—the servitisation of SMEs through strategic alliances—that focusses on interrelations among multiple forms of capital.
Glass formulation and composition optimization with property models: A review
Authors: Lu Xiaonan , Vienna John D. , Du Jincheng 
Published: July 2023

AbstractGlass is a versatile material with a remarkable history and many practical applications. It plays a critical role in our everyday lives, the advancement of science, and the development of many technologies. The Edisonian type trial‐and‐error method was commonly used for conventional design of glass compositions, which was time‐consuming and costly. With the urgent need to develop new glass compositions for technology applications rapidly, it has become necessary to develop precise property models with predictive powers using large databases and efficient formulation approaches. This paper reviews the design of glass compositions using these analytical and numerical models of composition–structure–property relations of glasses, some based on large databases and machine learning approaches. Aspects of data collection, model fitting, feature extraction, model evaluation, and uncertainty quantification will be covered. Furthermore, advances in the glass optimization framework and available tools are summarized with examples. The outlook and perspective for further glass property model development and formulation approaches are discussed.
Treatment of aged wound healing models withFGF2andABT‐737 reduces the senescent cell population and increases wound closure rate
Authors: Niyogi Upasana , Jara Carlos Poblete , Carlson Mark A. 
Published: July 2023

AbstractDelayed tissue repair in the aged presents a major socio‐economic and clinical problem. Age‐associated delay in wound healing can be attributed to multiple factors, including an increased presence of senescent cells persisting in the wound. Although the transient presence of senescent cells is physiologic during the resolution phase of normal healing, increased senescent cell accumulation with age can negatively impact tissue repair. Theobjectiveof the study was to test interventional strategies that could mitigate the negative effect of senescent cell accumulation and possibly improve the age‐associated delay in wound healing. We utilised a 3D in vitro senescent fibroblast populated collagen matrix (FPCM) to study cellular events associated with senescence and delayed healing. Senescent fibroblasts showed an increase in anti‐apoptotic B‐cell lymphoma 2 (BCL‐2) family proteins. We hypothesized that reducing the senescent cell population and promoting non‐senescent cell functionality would mitigate the negative effect of senescence and improve healing kinetics. BCL‐2 inhibition and mitogen stimulation (FGF2) improved healing in the in vitro senescent models. These results were confirmed with an ex vivo human skin biopsy model. These data suggested that modulation of the senescent cell population with soluble factors improved the healing outcome in our in vitro and ex vivo healing models.
Approximately unbiased estimators of the inverse variance from sample summary statistics
Authors: Balakrishnan Narayanaswamy , Rychtář Jan , Taylor Dewey , Walter Stephen D. 
Published: July 2023

Background In meta-analysis, researchers often pool the results from a set of similar studies. A number of studies, however, often tend to report only the minimum and maximum values, median, and/or the first and third quartiles. Recently, many methods have been discussed for estimating the mean and standard deviation from those sample summaries. However, these methods may provide a substantially biased estimate of the inverse variance that is needed for the meta-analysis. Research Design We use Basu’s theorem to derive unbiased estimators for σ−2 from the most commonly used sample summaries from the normal distribution. While there are no closed formulas for these estimators, we use simulations to obtain simple approximations for the estimators. Results The proposed approximate estimators still show a little to no bias for normally distributed data and generally show smaller bias than the usual methods even for some non-normal distributions. The proposed estimators have lower mean squared error. Conclusions The proposed estimators are recommended for the purpose of obtaining inverse-variance weights, particularly in the context of meta-analyses.