bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects from Time Dependence of Ice Nucleus Activity for Contrasting Cloud Types
Authors: Waman Deepak , Deshmukh Akash , Jadav Arti , Patade Sachin , Gautam Martanda , Phillips Vaughan , Bansemer Aaron , Jakobsson Jonas 
Published: March 2023

Abstract
The role of time-dependent freezing of ice nucleating particles (INPs) is evaluated with the “Aerosol–Cloud” (AC) model in 1) deep convection observed over Oklahoma during the Midlatitude Continental Convective Cloud Experiment (MC3E), 2) orographic clouds observed over North California during the Atmospheric Radiation Measurement (ARM) Cloud Aerosol Precipitation Experiment (ACAPEX), and 3) supercooled, stratiform clouds over the United Kingdom, observed during the Aerosol Properties, Processes And Influences on the Earth’s climate (APPRAISE) campaign. AC uses the dynamical core of the WRF Model and has hybrid bin–bulk microphysics and a 3D mesoscale domain. AC is validated against coincident aircraft, ground-based, and satellite observations for all three cases. Filtered concentrations of ice (>0.1–0.2 mm) agree with those observed at all sampled levels. AC predicts the INP activity of various types of aerosol particles with an empirical parameterization (EP), which follows a singular approach (no time dependence). Here, the EP is modified to represent time-dependent INP activity by a purely empirical approach, using our published laboratory observations of time-dependent INP activity. In all simulated clouds, the inclusion of time dependence increases the predicted INP activity of mineral dust particles by 0.5–1 order of magnitude. However, there is little impact on the cloud glaciation because the total ice is mostly (80%–90%) from secondary ice production (SIP) at levels warmer than about −36°C. The Hallett–Mossop process and fragmentation in ice–ice collisions together initiate about 70% of the total ice, whereas fragmentation during both raindrop freezing and sublimation contributes <10%. Overall, total ice concentrations and SIP are unaffected by time-dependent INP activity. In the simulated APPRAISE case, the main causes of persistence of long-lived clouds and precipitation are predicted to be SIP in weak embedded convection and reactivation following recirculation of dust particles in supercooled layer cloud.
Understanding Arctic Sea Ice Thickness Predictability by a Markov Model
Authors: Wang Yunhe , Yuan Xiaojun , Bi Haibo , Ren Yibin , Liang Yu , Li Cuihua , Li Xiaofeng 
Published: March 2023

Abstract
The Arctic sea ice decline and associated change in maritime accessibility have created a pressing need for sea ice thickness (SIT) predictions. This study developed a linear Markov model for the seasonal prediction of model-assimilated SIT. It tested the performance of physically relevant predictors by a series of sensitivity tests. As measured by the anomaly correlation coefficient (ACC) and root-mean-square error (RMSE), the SIT prediction skill was evaluated in different Arctic regions and across all seasons. The results show that SIT prediction has better skill in the cold season than in the warm season. The model performs best in the Arctic basin up to 12 months in advance with ACCs of 0.7–0.8. Linear trend contributions to model skill increase with lead months. Although monthly SIT trends contribute largely to the model skill, the model remains skillful up to 2-month leads with ACCs of 0.6 for detrended SIT predictions in many Arctic regions. In addition, the Markov model’s skill generally outperforms an anomaly persistence forecast even after all trends were removed. It also shows that, apart from SIT itself, upper-ocean heat content (OHC) generally contributes more to SIT prediction skill than other variables. Sea ice concentration (SIC) is a relatively less sensitive predictor for SIT prediction skill than OHC. Moreover, the Markov model can capture the melt-to-growth season reemergence of SIT predictability and does not show a spring predictability barrier, which has previously been observed in regional dynamical model forecasts of September sea ice area, suggesting that the Markov model is an effective tool for SIT seasonal predictions.
Treatment of Olfactory Disorders After SARS – CoViD 2 Virus Infection
Authors: Schmidt F. , Azar C. , Goektas O. 
Published: March 2023

Objective The benefit of a nasal corticosteroid in the treatment of persistent post-infectious smell disorders is not as clear in previous studies as is assumed for olfactory training. This study would therefore like to describe the treatment strategies using the example of a persistent olfactory dysfunction as a result of a proven infection with SARS-CoViD-2-virus. Methods Twenty patients (average age of 33.9 ± 11.9 years) with hyposmia were included in this study from December 2020 to July 2021. Every second patient received additionally a nasal corticosteroid. The two resulting randomized groups of equal size were screened with the TDI test, a 20-item taste powder test for the assessment of retronasal olfaction and otorhinolaryngological examination. The patients were asked to train twice daily using a standardized odor training kit and followed up after 2 months and 3 months, respectively. Results We documented a significant overall improvement in olfactory ability over the investigation period in both groups. While the TDI score steadily increased on average under the combination therapy, the rise under olfactory training alone was initially steeper. This short-term interaction effect over mean two months was not statistically significant. According to Cohen, however, a moderate effect (eta 2 = 0.055, Cohen`s d = 0.5) can still be assumed. This effect could be explained by a possibly higher compliance at the beginning of the sole olfactory training due to the lack of further drug treatment offers. When the training intensity decreases, the recovery of the sense of smell stagnates. Adjunctive therapy ultimately outweighs this short-term benefit. Conclusions The results reinforce the recommendation of early and consistent olfactory training on patients with dysosmia due to COVID-19. For continuous improvement of the sense of smell, an accompanying topical treatment seems at least to be worth consideration. The results should be optimized with larger cohorts and using new objective olfactometric methods.
Medical Outcomes of Acute Aspirin Single Substance Poisoning in Pediatric Patients
Authors: Daniel-McCalla Shawnée N. , Parbuoni Kristine A. , Leonard James , Morgan Jill A. , Kishk Omayma A. , Biggs Jessica M. , Anderson Bruce D. 
Published: March 2023

Background: A consensus guideline on salicylate poisoning recommends referring patients to the emergency department if they ingested 150 mg/kg of aspirin. The dose of aspirin associated with severe poisoning in pediatric patients has not been investigated. Objective: This study aims to associate medical outcomes with aspirin overdoses in patients 5 years old and younger. Methods: A retrospective review of data on pediatric patients with single substance aspirin exposures reported from poison centers across the country was conducted. The primary endpoint was to associate aspirin doses with medical outcomes. Secondary endpoints included evaluation of the signs, symptoms, and treatments of ingestion and their association with medical outcomes. Results: There were 26 488 included exposures with aspirin exposures resulting in no effect (92.5%), minor effect (6.0%), moderate effect (1.4%), major effect (0.2%), and death (0.02%). There were 8921 cases with available weight-based dosing information. Median doses associated with no effect, minor effects, moderate effects, major effects, and death ranged between 28.4 and 40.9 mg/kg, 52.5 and 82.3 mg/kg, 132.1 and 182.3 mg/kg, 132.3 and 172.8 mg/kg, and 142.2 and 284.4 mg/kg, respectively. Minor effect and moderate effect exposures were more likely to have alkalinization documented compared to no effect exposures (odds ratio [OR] = 1.75, 95% confidence interval [CI] = 1.41-2.17; OR = 1.79, 95% CI = 1.12-2.86). There was no difference in rates of alkalinization between minor and moderate exposures (OR = 1.02, 95% CI: 0.61-1.7). Conclusions and relevance: Reevaluation of the current recommendation of 150 mg/kg for referral to a healthcare facility is necessary for pediatric acute salicylate overdoses.
Serum levels of interleukin-18 in diabetic retinopathy patients: A meta-analysis
Authors: Jiang Yingling , Zhou Lihua , Yao Li 
Published: March 2023

Purpose To assess the relationship between plasma interleukin-18 (IL-18) levels and the risk of diabetic retinopathy (DR). Materials and methods PubMed, Embase, Web of science, and Cochrane were reviewed systemically from inception to August 2022. Searches were performed using a combined term that included all spellings of “diabetic retinopathy,” and “interleukin-18”. Eligible studies were retrospective studies reporting changes in IL-18 levels between the DR group and the control group. The healthy controls had no identifiable DR disease. Pooled outcomes were reported as standard mean difference (SMD) with 95% confidence intervals (CI) with a random-effects model. Heterogeneity was assessed using the I2 statistics, and it was considered significant if I2 > 75%. Publication bias was evaluated using funnel plots and Begg's and Egger's tests. A meta-analysis was conducted using STATA 12.0 (StataCorp LLC, College Station, TX, USA). Results 7 studies and four countries incorporated 160 cases, and 119 controls were incorporated in this meta-analysis. When comparing subjects without DR, those with DR tended to have higher serum IL-18 levels (SMD = 3.41, 95% CI = 1.84–4.97). Publication bias indicated that no publication bias existed in the study. Conclusions Elevated circulating IL-18 levels may be one of the significant risk factors positively correlated with the development of DR. Future studies should clarify the mechanism behind this trend.
Efficacy and safety of UT-DSAEK combined with Carlevale's sutureless scleral fixation IOL
Authors: Vaiano Agostino S , Greco Antonio , Greco Andrea , Toro Maria E , Leto Marco G , Savini Giacomo 
Published: March 2023

Purpose To evaluate a novel surgical combination of ultrathin Descemet stripping automated endothelial keratoplasty (UT-DSAEK) and sutureless scleral fixation for Carlevale intraocular lens (SSF-Carlevale IOL) implantation to manage corneal endothelial decompensation when there is a concomitant need for secondary IOL fixation. Methods Clinical data collected from 10 eyes of 9 patients with bullous keratopathy (BK) who underwent combined UT-DSAEK and SSF-Carlevale IOL implantation in a single procedure were retrospectively analyzed. Anterior chamber IOL (4 cases), aphakia (4 cases, 1 of which associated with PEX), and previous trauma (2 cases) were the conditions responsible for BK. Corrected distance visual acuity (CDVA), intraocular pressure (IOP), endothelial cell density (ECD), central corneal thickness (CCT), graft thickness (GT) and complications were recorded over a 12-month follow-up period. Results In 90% (9/10) of eyes graft clarity was maintained during follow-up. The mean CDVA improved significantly (p < 0.0001) from 1.78 ± 0.76 logMAR preoperatively to 0.53 ± 0.3 logMAR at 12 months. ECD on average decreased from 2575 ± 125.3 cells/mm2 (donor tissue) to 1697 ± 133.3 cells/mm2 in 12 months. The mean CCT decreased from 870 ± 200 µm to 650 µm ± 9 at 12 months (ANOVA, p = 0.0005). Conclusions Combined UT-DSAEK and SSF-Carlevale IOL implantation was associated with good corneal graft survival and IOP control, with few complications. These findings suggest that this surgical approach is a practical option for patients requiring both treatment for corneal endothelial dysfunction and secondary IOL implantation.
Humoral immune responses remain quantitatively impaired but improve qualitatively in anti-CD20-treated patients with multiple sclerosis after three or four COVID-19 vaccinations
Authors: Otto Carolin , Schwarz Tatjana , Jeworowski Lara M , Schmidt Marie L , Walper Felix , Pache Florence , Schindler Patrick , Niederschweiberer Moritz , Krumbholz Andi , Rose Ruben , Drosten Christian , Ruprecht Klemens , Corman Victor M 
Published: March 2023

Objective: To analyze anti-SARS-CoV-2-S1-IgG levels, avidity, Omicron BA.2 variant neutralizing capacity, and SARS-CoV-2-specific T cells in anti-CD20-treated patients with multiple sclerosis (aCD20pwMS) after two, three, or four COVID-19 vaccinations. Results: Frequencies of aCD20pwMS with detectable SARS-CoV-2-S1-IgG increased moderately between two (31/61 (51%)), three (31/57 (54%)), and four (17/26 (65%)) vaccinations. However, among patients with detectable SARS-CoV-2-S1-IgG, frequencies of high avidity (6/31 (19%) vs 11/17 (65%)) and Omicron neutralizing antibodies (0/10 (0%) vs 6/10 (60%)) increased strongly between two and four vaccinations. SARS-CoV-2-specific T cells were detectable in >92% after two or more vaccinations Conclusion: Additional vaccinations qualitatively improve SARS-CoV-2 antibody responses.
Telemedicine is associated with reduced socioeconomic disparities in outpatient clinic no-show rates
Authors: Qin Jimmy , Chan Carri W , Dong Jing , Homma Shunichi , Ye Siqin 
Published: March 2023

Introduction The global pandemic caused by coronavirus (COVID-19) sped up the adoption of telemedicine. We aimed to assess whether factors associated with no-show differed between in-person and telemedicine visits. The focus is on understanding how social economic factors affect patient no-show for the two modalities of visits. Methods We utilized electronic health records data for outpatient internal medicine visits at a large urban academic medical center, from February 1, 2020 to December 31, 2020. A mixed-effect logistic regression was used. We performed stratified analysis for each modality of visit and a combined analysis with interaction terms between exposure variables and visit modality. Results A total of 111,725 visits for 72,603 patients were identified. Patient demographics (age, gender, race, income, partner), lead days, and primary insurance were significantly different between the two visit modalities. Our multivariable regression analyses showed that the impact of sociodemographic factors, such as Medicaid insurance (OR 1.23, p < 0.01 for in-person; OR 1.03, p = 0.57 for telemedicine; p < 0.01 for interaction), Medicare insurance (OR 1.11, p = 0.04 for in-person; OR 0.95, p = 0.32 for telemedicine; p = 0.03 for interaction) and Black race (OR 1.36, p < 0.01 for in-person; OR 1.20, p < 0.01 for telemedicine; p = 0.03 for interaction), on increased odds of no-show was less for telemedicine visits than for in-person visits. In addition, inclement weather and younger age had less impact on no-show for telemedicine visits. Discussion Our findings indicated that if adopted successfully, telemedicine had the potential to reduce no-show rate for vulnerable patient groups and reduce the disparity between patients from different socioeconomic backgrounds.
Therapeutic alliance in videoconferencing psychotherapy compared to psychotherapy in person: A systematic review and meta-analysis
Authors: Seuling Patrik D , Fendel Johannes C , Spille Lukas , Göritz Anja S , Schmidt Stefan 
Published: March 2023

Introduction Videoconferencing psychotherapy (VCP) delivers treatment to individuals with limited access to face-to-face mental healthcare. VCP's effectiveness has been demonstrated for various disorders and therapeutic interventions. However, there is contradictory evidence regarding the therapeutic alliance in VCP as compared to psychotherapy in person (PIP). This meta-analysis examines whether therapeutic alliance differs by psychotherapy's delivery format, namely VCP versus PIP. Methods We searched five databases for trials comparing the therapeutic alliance in VCP and PIP, wherein the therapeutic alliance was rated by either patients or therapists or both. Eighteen publications were included, and the difference between VCP and PIP was assessed. Furthermore, we tested possible moderators of the difference in therapeutic alliance between VCP and PIP by meta-regression, and we assessed the risk of bias of this meta-analysis. Results The meta-analysis revealed no statistically significant difference in the therapeutic alliance between VCP and PIP for alliance ratings by patients (SMD = −0.09; 95% CI = −0.26; 0.07) as well as by therapists (SMD = 0.04; 95% CI = −0.17; 0.25). No significant moderators were found. Discussion In this meta-analysis, VCP and PIP did not differ with respect to the therapeutic alliance as rated by either patients or therapists. Further research is required into mechanisms driving the therapeutic alliance in VCP and PIP.
Assessment of Patellar Vascularity after Patellar Cartilage Restoration via Lateral Parapatellar Approach: Analysis Using Dynamic Contrast-Enhanced Magnetic Resonance Imaging
Authors: Uppstrom Tyler J. , Breighner Ryan E. , Fletcher Connor , Mintz Douglas N. , Strickland Sabrina A. 
Published: March 2023

Objective Patellofemoral cartilage restoration procedures, including osteochondral allograft, particulated juvenile cartilage, and matrix-induced autologous chondrocyte implantation, have been shown to be effective treatments for patellofemoral cartilage lesions. However, concerns exist regarding disruption of the patellar vascular supply and secondary stabilizers of the patellofemoral joint during medial parapatellar approaches, especially when combined with a lateral release. A lateral parapatellar approach affords the possibility of avoiding disruption of the medial blood supply to the patella, while also allowing laterally-based soft tissue stabilization procedures. The purpose of this study was to investigate in vivo changes in patellar vascularity following patellofemoral cartilage restoration procedures performed via a lateral parapatellar approach via use of dynamic contrast-enhanced magnetic resonance (MR) imaging. Design This study is a prospective case series of 5 adult patients undergoing patellofemoral cartilage restoration procedures via a lateral parapatellar approach with pre-operative and post-operative dynamic contrast-enhanced MR imaging to assess changes in patellar vascularity. Secondary outcomes included knee range of motion, need for revision surgery, and complications. Results There was no significant post-operative difference in patellar vascularity in patients undergoing patellofemoral cartilage restoration procedures via a lateral parapatellar approach, as evaluated by qualitative MR imaging. Conclusion Our results suggest that a lateral parapatellar approach for cartilage restoration procedures may preserve patellar vascularity, while also allowing for lateral release to be performed through the same incision.
Co-design of the web-based ‘My Knee’ education and self-management toolkit for people with knee osteoarthritis
Authors: Goff Anthony J , De Oliveira Silva Danilo , Ezzat Allison M , Crossley Kay M , Pazzinatto Marcella F , Barton Christian J ,   Lived Experience Group and Health Professional Group
Published: March 2023

Objective Describe the co-design process and learnings related to developing the web-based Translating Research Evidence and Knowledge (TREK) ‘My Knee’ education and self-management toolkit for people with knee osteoarthritis. Co-design process Stage (i): Understand and define; systematically reviewed education interventions in published trials; appraised web-based information about knee osteoarthritis; and used concept mapping to identify education priorities of people with knee osteoarthritis and physiotherapists. Stage (ii): Prototype; created a theory-, guideline- and evidence-informed toolkit. Stage (iii): Test and iterate; completed three co-design workshops with end-users (i.e., people with knee osteoarthritis and health professionals); plus an expert review. Results The toolkit is available at myknee.trekeducation.org. Stage (i) identified the need for more accurate and co-designed resources to address broad education needs generated during concept mapping, including guidance on surgery, dispelling common misconceptions and facilitating engagement with exercise therapy and weight management. A theory- and research-informed prototype was created in Stage (ii) to address broad learning and education needs. Stage (iii) co-design workshops ( n =  15 people with osteoarthritis and n =  9 health professionals) informed further content creation and refinement, alongside improvements to optimise usability. Expert opinion review ( n =  8) further refined accuracy and usability. Conclusions The novel co-design methodology employed to create the TREK ‘My Knee’ toolkit facilitated the alignment of the content and usability to meet the broad education needs of people with knee osteoarthritis and health professionals. This toolkit aims to improve and facilitate engagement with guideline-recommended first-line care for people with knee osteoarthritis. Future work will determine its effectiveness in improving clinical outcomes in this population.
Preferences for Decision Control among a High-Risk Cohort Offered Lung Cancer Screening: A Brief Report of Secondary Analyses from the Lung Screen Uptake Trial (LSUT)
Authors: Bonfield Stefanie , Ruparel Mamta , Waller Jo , Dickson Jennifer L. , Janes Samuel M. , Quaife Samantha L. 
Published: March 2023

Background. Personal autonomy in lung cancer screening is advocated internationally, but health systems diverge in their approach, mandating either shared decision making (with a health care professional) or individual decision making. Studies of other cancer screening programs have found that individual preferences for the level of involvement in screening decisions vary across different sociodemographic groups and that aligning approaches with individual preferences has the potential to improve uptake. Method. For the first time, we examined preferences for decision control among a cohort of UK-based high-risk lung cancer screening candidates ( N = 727). We used descriptive statistics to report the distribution of preferences and chi-square tests to examine associations between decision preferences and sociodemographic variables. Results. Most (69.7%) preferred to be involved in the decision with varying degrees of input from a health care professional. Few (10.2%) wanted to make the decision alone. Preferences were also associated with educational attainment. Conclusion. These findings suggest one-size-fits-all approaches may be inadequate in meeting diverse preferences, particularly those placing sole onus on the individual. Highlights Preferences for involvement in decision making about lung cancer screening are heterogeneous among high-risk individuals in the United Kingdom and vary by educational attainment. Further work is needed to understand how policy makers might implement hybrid approaches to accommodate individual preferences and optimize lung cancer screening program outcomes.