bluuebunny/crossref_metadata_2025_split huggingface dataset:
Labour and premature delivery differentially affect the expression of the endocannabinoid system in the human placenta
Authors: Taylor Anthony H. , Bachkangi Panos , Konje Justin C. 
Published: September 2023

AbstractPlasma concentrations of N-arachidonyletholamine (AEA), N-oleoylethanolamide (OEA) and N-palmitoylethanolamide (PEA) increase at term and can predict when a woman is likely to go into labour. We hypothesised that increased plasma AEA concentrations in women in preterm and term labour might also be increased and have a function in the placenta at the end of pregnancy. Here we examined the expression of the N-acylethanolamine-modulating enzymes fatty acid amide hydrolase (FAAH) and N-acyl-phosphatidylethanolamine-specific phospholipase-D (NAPE-PLD) and of the cannabinoid receptors (CB1 and CB2) in the placenta and their activation in an in vitro model of the third-trimester placenta to determine if those expressions change with labour and have functional significance. Expression of CB1, CB2, FAAH and NAPE-PLD was examined by immunohistochemistry (IHC) and RT-qPCR in placental samples obtained from four patient groups: preterm not in labour (PTNL), term not in labour (TNL), preterm in labour (PTL) and term in labour (TL). Additionally, the effects of AEA on a third-trimester human cell line (TCL-1) were evaluated. All ECS components were present in the third-trimester placenta, with NAPE-PLD and CB2 being the key modulated proteins in terms of expression. Functionally, AEA reduced TCL-1 cell numbers through the actions of the CB2 receptor whilst CB1 maintained placental integrity through the expression of the transcription regulators histone deacetylase 3, thyroid hormone receptor β 1 and the modulation of 5α reductase type 1. The placenta in the third trimester and at term is different from the placenta in the first trimester with respect to the expression of CB1, CB2, FAAH and NAPE-PLD, and the expression of these proteins is affected by labour. These data suggest that early perturbation of some ECS components in the placenta may cause AEA-induced PTL and thus PTB.
Clinical characteristics of sarcoma patients: a population-based data analysis from a German clinical cancer registry
Authors: Müller Jörg Andreas , Delank Karl-Stefan , Laudner Kevin , Wittenberg Ian , Zeh Alexander , Vordermark Dirk , Medenwald Daniel 
Published: September 2023

Abstract
Purpose
Sarcomas are a heterogeneous group of malignant neoplasms with a wide range of histological types and occur in almost any anatomic site and side. This study evaluated the prognostic factors in sarcoma patients based on German clinical cancer registry data.

Methods
The German clinical cancer register of Saxony-Anhalt was used for all data analyses. Sarcoma cases of all clinical or pathological T-stages (T1a–T4c), all N-stages (N0-3) and M-stages (0–1b) corresponding to the Union for International Cancer Control (UICC) stages I to IVB were considered. In our analyses, 787 cases diagnosed between 2005 and 2022 were included. Further, we assessed the association of cancer-related parameters with mortality and hazard ratios (HR) from the Cox proportional hazard models. We included sex, age at diagnosis, histological grade, T-, N- and M-stages, tumor size, tumor localization and tumor side as parameters in our regression models.

Results
The majority of sarcoma patients were diagnosed with leiomyosarcoma (12%), liposarcoma (11%), angiosarcoma (5.3%) and myxofibrosarcoma (2.7%). In our univariate regression models, tumors localized in more than one location, head, face and neck region as well as the pelvis and lower extremity were associated with increased mortality risk (more than one location: HR 7.10, 95% CI 2.20–22.9; head, face and neck: HR 1.35, 95% CI 0.89–2.06; pelvis: HR 1.27, 95% CI 0.86–1.89; lower extremity: HR 1.44, 95% CI 1.05–1.96). Higher histological grades, UICC-grades and TNM-stages were related to a higher mortality risk. Differing histological subtypes had significant influence on overall survival and progression-free survival. Patients diagnosed with fibromyxoid sarcoma, rhabdomyosarcoma and angiosarcoma were related to higher mortality risk compared to other histological subtypes (fibromyxoid sarcoma: HR 5.2, 95% CI 0.71–38.1; rhabdomyosarcoma: HR 2.93, 95% CI 1.44–6.00; angiosarcoma: HR 1.07, 95% CI 0.53–2.18).

Conclusions
Histological grade, tumor size, nodal and distant metastasis, tumor localization and histological subtype were determined as prognostic factors in terms of survival.
Stationary local random countable sets over the Wiener noise
Authors: Vidmar Matija , Warren Jon 
Published: September 2023

AbstractThe times of Brownian local minima, maxima and their union are three distinct examples of local, stationary, dense, random countable sets associated with classical Wiener noise. Being local means, roughly, determined by the local behavior of the sample paths of the Brownian motion, and stationary means invariant relative to the Lévy shifts of the sample paths. We answer to the affirmative Tsirelson’s question, whether or not there are any others, and develop some general theory for such sets. An extra ingredient to their structure, that of an honest indexation, leads to a splitting result that is akin to the Wiener–Hopf factorization of the Brownian motion at the minimum (or maximum) and has the latter as a special case. Sets admitting an honest indexation are moreover shown to have the property that no stopping time belongs to them with positive probability. They are also minimal: they do not have any non-empty proper local stationary subsets. Random sets, of the kind studied in this paper, honestly indexed or otherwise, give rise to nonclassical one-dimensional noises, generalizing the noise of splitting. Some properties of these noises and the inter-relations between them are investigated. In particular, subsets are connected to subnoises.
Comparative analysis of the molecular and physiological consequences of constitutive SKN-1 activation
Authors: Ramos Carmen M. , Curran Sean P. 
Published: September 2023

AbstractMolecular homeostats play essential roles across all levels of biological organization to ensure a return to normal function after responding to abnormal internal and environmental events. SKN-1 is an evolutionarily conserved cytoprotective transcription factor that is integral for the maintenance of cellular homeostasis upon exposure to a variety of stress conditions. Despite the essentiality of turning on SKN-1/NRF2 in response to exogenous and endogenous stress, animals with chronic activation of SKN-1 display premature loss of health with age, and ultimately, diminished lifespan. Previous genetic models of constitutive SKN-1 activation include gain-of-function alleles of skn-1 and loss-of-function alleles of wdr-23 that impede the turnover of SKN-1 by the ubiquitin proteasome. Here, we define a novel gain-of-function mutation in the xrep-4 locus that results in constitutive activation of SKN-1 in the absence of stress. Although each of these genetic mutations results in continuously unregulated transcriptional output from SKN-1, the physiological consequences of each model on development, stress resistance, reproduction, lipid homeostasis, and lifespan are distinct. Here, we provide a comprehensive assessment of the differential healthspan impacts across multiple models of constitutive SKN-1 activation. Although our results reveal the universal need to reign in the uncontrolled activity of cytoprotective transcription factors, we also define the unique signatures of each model of constitutive SKN-1 activation, which provides innovative solutions for the design of molecular “off-switches” of unregulated transcriptional homeostats.
CT-based body composition in diffuse large B cell lymphoma patients: changes after treatment and association with survival
Authors: Pirosa Maria Cristina , Esposito Fabiana , Raia Giorgio , Chianca Vito , Cozzi Andrea , Ruinelli Lorenzo , Ceriani Luca , Zucca Emanuele , Del Grande Filippo , Rizzo Stefania 
Published: September 2023

Abstract
Purpose
Primary purpose was to assess changes of bone mineral density (BMD) in diffuse large B cell lymphoma (DLBCL) patients treated with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone R-CHOP (like) chemotherapy regimen. Secondary purposes were to assess other body composition features changes and to assess the association of pre-therapy values and their changes over time with survival.

Material and methods
Patients selected underwent R-CHOP(like) regimen for DLBCL, and underwent PET-CT before and after treatment. Main clinical data collected included body mass index, date of last follow-up, date of progression, and date of death. From the low-dose CT images, BMD was assessed at the L1 level; the other body composition values, including muscle and fat distribution, were assessed at the L3 level by using a dedicated software. Descriptive statistics were reported as median and interquartile range, or frequencies and percentages. Statistical comparisons of body composition variables between pre- and post-treatment assessments were performed using the Wilcoxon matched pairs signed rank test. Non-normal distribution of variables was tested with the Shapiro–Wilk test. For qualitative variables, the Fisher exact test was used. Log rank test was used to compare survival between different subgroups of the study population defined by specific body composition cutoffs. The significance level was set at p < 0.05.

Results
Eighty-two patients were included. The mean follow-up was 37.5 ± 21.4 months. A significant difference was found in mean BMD before and after R-CHOP(like) treatment (p < 0.0001). The same trend was observed for mean skeletal muscle area (SMA) (p = 0.004) and mean skeletal muscle index (SMI) (p = 0.006). No significant association was demonstrated between body composition variables, PFS and OS.

Conclusion
R-CHOP(like) treatment in DLBCL patients was associated with significant reduction of BMD, SMA and SMI.
Discriminatory Residential Preferences in Germany—A Vignette Study
Authors: Wolter Felix , Raviv Or Cohen , Mertens Maila 
Published: September 2023

AbstractThe article focusses on the generating mechanisms of residential segregation for the demand side of housing markets, i.e., discriminatory residential preferences of inhabitants regarding the composition of their neighborhood. The data stem from an online survey among a random sample of the population of a mid-sized German city. In a vignette experiment, respondents were asked to rate example residential settings with respect to their attractiveness. The settings varied regarding the ethnic and religious composition of the neighborhood and other neighborhood characteristics that are positively or negatively related to residential attractiveness.We find that respondents have discriminatory residential preferences toward migrants and the presence of a Muslim community in the neighborhood. One-half of the migrant effect is mitigated if other positively connoted residential characteristics exist. We take this as an indication for statistical discrimination. This does not hold for the “Muslim community” effect. Discrimination gets stronger with higher levels of perceived economic group-threat from migrants. We further find evidence for a cultural group-threat and for the contact hypothesis: religious people are more discriminatory than nonreligious people, and real-life contact with migrants entails less discrimination.
Managing Temporomandibular Joint Osteoarthritis by Dental Stem Cell Secretome
Authors: Bousnaki Maria , Bakopoulou Athina , Grivas Ioannis , Bekiari Chrysa , Pich Andreas , Rizk Marta , Keklikoglou Kleoniki , Papachristou Eleni , Papadopoulos Georgios C. , Kritis Aristeidis , Mikos Antonios G. , Koidis Petros 
Published: September 2023

AbstractThe potential therapeutic role of the Dental Pulp Stem Cells Secretome (SECR) in a rat model of experimentally induced Temporomandibular Joint (TMJ) Osteoarthritis (OA) was evaluated. Proteomic profiling of the human SECR under specific oxygen tension (5% O2) and stimulation with Tumor Necrosis Factor-alpha (TNF-α) was performed. SECR and respective cell lysates (CL) samples were collected and subjected to SDS-PAGE, followed by LC-MS/MS analysis. The identified proteins were analyzed with Bioinformatic tools. The anti-inflammatory properties of SECR were assessed via an in vitro murine macrophages model, and were further validated in vivo, in a rat model of chemically-induced TMJ-OA by weekly recording of the head withdrawal threshold, the food intake, and the weight change, and radiographically and histologically at 4- and 8-weeks post-treatment. SECR analysis revealed the presence of 50 proteins that were enriched and/or statistically significantly upregulated compared to CL, while many of those proteins were involved in pathways related to “extracellular matrix organization” and “immune system”. SECR application in vitro led to a significant downregulation on the expression of pro-inflammatory genes (MMP-13, MMP-9, MMP-3 and MCP-1), while maintaining an increased expression of IL-10 and IL-6. SECR application in vivo had a significant positive effect on all the clinical parameters, resulting in improved food intake, weight, and pain suppression. Radiographically, SECR application had a significant positive effect on trabecular bone thickness and bone density compared to the saline-treated group. Histological analysis indicated that SECR administration reduced inflammation, enhanced ECM and subchondral bone repair and regeneration, thus alleviating TMJ degeneration.
Graphical Abstract
Expected length of stay at residential aged care facilities in Australia: current and future
Authors: Zhang Jinhui , Shi Yanlin , Huang Guogui 
Published: September 2023

AbstractThis study explores the changing patterns of the length of stay (LOS) at Australian residential aged care facilities during 2008–2018 and likely trends up to 2040. The expected LOS was estimated via the hazard function of exiting from such a facility and its heterogeneity by residents’ sociodemographic characteristics using an improved Cox regression model. Data were sourced from the Australian Institute of Health and Welfare. In-sample modelling results reveal that the estimated LOS differed by age (in general, shorter for older groups), marital status (longer for the widowed) and sex (longer for females). In addition, the estimated LOS increased slowly from 2008–2009 to 2016–2017 but declined steadily thereafter. Out-of-sample predictions suggest that the declining trend of the estimated LOS will continue until 2040 and that the longest LOS (approximately 37 months) will be observed among widowed females aged 50–79 years. Relative uncertainty measures are provided. The results portray the current changing landscape and the future trend of residential aged care use in Australia, which can inform the development of optimised residential aged care policies to support ageing Australians more effectively.
Assessing mesoscale permeability in unsaturated, fractured, and karstified carbonate reservoirs: a joint geological, petrophysical, and hydraulic approach for the interpretation of injection tests
Authors: Danquigny Charles , Coqueret J. , Massonnat G. , Léonide P. , Barbier M. , Dal Soglio L. , Lesueur J. L. 
Published: September 2023

AbstractIn the study of subsurface reservoirs, permeability is a key parameter whose evaluation and extrapolation at the desired scale, such as that of the numerical model mesh, are both a necessity and a difficult task. Relating permeability measurements to the geological characteristics of the rock, at intermediate scales seldom characterized, can help understanding the heterogeneity of the medium and correctly determining the permeability at the desired scale. This concern is particularly important in karst reservoirs, which exhibit highly variable permeability at different scales of observation and from one location to another. Here, we study the petrophysical and geological properties of carbonate facies from the centimeter to the meter scale. Several boreholes a few meters apart were cored and exhaustively described. Petrophysical measurements were made on rock samples, while inter-packer injection tests were undertaken to investigate some meter intervals of the medium surrounding the wells. The results show that the investigated medium is a complex multi-medium with a multi-scale heterogeneity. The detailed geological description allowed explaining the differences between the permeability values at different scales and from one interval to another. Relationships were quantified between the texture of the limestone matrix, the density and aperture of the discontinuities, the permeability of the matrix, and the permeability contrast related to the dual medium at the meter scale. A strong correlation between this permeability contrast and the aperture of the discontinuities, itself more correlated to the texture of the rock than to the facies, is highlighted.
Efficiency of chemically activated raw and calcined waste fish bone for adsorption of Cd (II) and Pb (II) from polluted water
Authors: Rashed Mohamed Nageeb , Gad Aleya Abd ElMoneam , Fathy Nada Magdy 
Published: September 2023

AbstractBone biochar is used as an adsorbent in water pollution control because of its high surface area and pore volumes. This study is attempting to prepare a low-cost adsorbent from waste fish bones by chemical activation and use it for the removal of Cd2+ and Pb2+ from polluted water. The preparation of fish bone adsorbents involved two methods. The first method includes the chemical activation of waste fish bone using different chemical activators (0.001 M HNO3, 0.1 M NaOH, 0.5% H2O2, and ethanol) (FB), while the second one includes the calcination of waste fish bone after the chemical activation at 873 K (FB-Hy). The synthesized fish bone adsorbent (FB) was characterized by electron microscopy (SEM), X-ray diffractometer (XRD), X-ray fluorescence (XRF), Brunauer–Emmett–Teller (BET) surface area, and Fourier transform infrared (FT-IR). The effectiveness of the prepared adsorbent (FB) in removing Pb and Cd was evaluated based on contact time, solution pH, solution temperature, initial metal concentration, and adsorbent dose. Metal concentrations were measured by atomic absorption spectroscopy. The results show that 0.1 M NaOH activation of bone waste (FB) is suitable for higher adsorption of Cd2+ and Pb2+ compared with other activators. The maximum adsorption of Pb and Cd with the FB adsorbent was 99.74 and 99.35%, respectively, at optimum conditions (pH 6.0, contact time 30 min, initial metal concentration 10 ppm, adsorbent dosage 0.1 g, and temperature at 328 K). The results of kinetic adsorption obeyed a pseudo-second-order model. Freundlich and Langmuir isotherms were applied, and the adsorption was found to fit well with the Langmuir model. This study ended with the success of preparing an eco-friendly and low-cost fish bone adsorbent from the waste fish bone and using it for the removal of Cd2+ and Pb2+ from polluted water.
Enhancing robustness and noise rejection in flexible joint manipulators: an optimized sliding mode controller with enhanced gray wolf optimization for trajectory tracking
Authors: Azeez Muhammad I. , Elnaggar S. , Abdelhaleem A. M. M. , Moustafa Kamal A. F. , Atia Khaled R. 
Published: September 2023

AbstractThe objective of this study is to enhance the performance of a nonlinear three-rigid-link manipulator (RLM) with a focus on trajectory tracking, robustness against disturbances and noises, and adaptability to joint flexibility. To achieve this, we have employed an optimized sliding mode controller with a proportional integral derivative (PID) sliding manifold. The tuning process involves selecting the critical gains of the controller that minimizes the integral time absolute error (ITAE), serving as the objective function (OBJF) to optimize the performance of the robot manipulator. To identify the optimal gains of the controller, we have utilized a new optimization algorithm known as memory enhanced linear population size reduction gray wolf optimization (MELGWO). The efficacy of this algorithm is compared to other existing optimization methods in the literature. Moreover, this research has delved into the impact of joint flexibility on the robot system’s performance. Encouragingly, the results demonstrate that the optimized SMC–PID with MELGWO adaptation can effectively address joint flexibility while maintaining acceptable performance levels.
Evaluation of a large set of patients with Autoimmune Polyglandular Syndrome from a single reference centre in context of different classifications
Authors: Gatta E. , Maltese V. , Cimino E. , Cavadini M. , Anelli V. , Di Lodovico E. , Piovani E. , Zammarchi I. , Gozzoli G. , Agosti B. , Pirola I. , Delbarba A. , Girelli A. , Buoso C. , Bambini F. , Alfieri D. , Bremi W. , Facondo P. , Lupo R. , Bezzi F. , Fredi M. , Mazzola A. M. , Gandossi E. , Saullo M. , Marini F. , Licini M. , Pezzaioli L. C. , Pini L. , Franceschini F. , Ricci C. , Cappelli C. 
Published: September 2023

Abstract
Purpose
To characterize patients with APS and to propose a new approach for their follow-up. Query ID="Q1" Text="Please check the given names and familynames."

Methods
Monocentric observational retrospective study enrolling patients referred to the Outpatients clinic of the Units of Endocrinology, Diabetology, Gastroenterology, Rheumatology and Clinical Immunology of our Hospital for Autoimmune diseases.

Results
Among 9852 patients, 1174 (11.9%) [869 (73.9%) female] were diagnosed with APS. In 254 subjects, the diagnosis was made at first clinical evaluation (Group 1), all the other patients were diagnosed with a mean latency of 11.3 ± 10.6 years (Group 2). Group 1 and 2 were comparable for age at diagnosis (35.7 ± 16.3 vs. 40.4 ± 16.6 yrs, p = .698), but different in male/female ratio (81/173 vs 226/696, p = .019). In Group 2, 50% of patients developed the syndrome within 8 years of follow-up. A significant difference was found after subdividing the first clinical manifestation into the different outpatient clinic to which they referred (8.7 ± 8.0 vs. 13.4 ± 11.6 vs. 19.8 ± 8.7 vs. 7.4 ± 8.1 for endocrine, diabetic, rheumatologic, and gastroenterological diseases, respectively, p < .001).

Conclusions
We described a large series of patients affected by APS according to splitters and lumpers. We propose a flowchart tailored for each specialist outpatient clinic taking care of the patients. Finally, we recommend regular reproductive system assessment due to the non-negligible risk of developing premature ovarian failure.