bluuebunny/crossref_metadata_2025_split huggingface dataset:
Предиктори утримання синусового ритму в пацієнтів із пізньою персистентною фібриляцією передсердь після електричної кардіоверсії під час 6-місячного проспективного спостереження
Authors: Skybchyk Ya. V. , Zharinov O. J. 
Published: September 2023

The aim – to study the predictors of sinus rhythm (SR) maintenance in patients with persistent atrial fibrillation (AF) and duration of AF episode ≥90 days at 6-months follow-up after elective direct current (DC) cardioversion.Materials and methods. The cohort single-center study analyzed clinical and instrumental data from 59 persistent AF patients with duration of its episode ≥90 days (up to 12 months), who underwent an elective DC cardioversion. At 6-months follow-up, patients were subdivided into the groups depending on SR maintenance: 32 (54 %) patients with a maintained SR (G1), and 27 (46 %) patients with a failure to maintain SR (G2).Results. G2, as compared to G1, demonstrated more advanced heart failure (stage C occurred in 74 % and 44 %, respectively [p=0,019]). According to transthoracic echocardiography (TTE) data, G1, as opposed to G2, was characterized by better baseline structure parameters of left heart chambers, particularly the diameter of left atrium (LA), end-diastolic and end-systolic volumes left ventricular (LV) volumes, higher LV systolic function (by LV ejection fraction [EF]), and the majority of the cases without or with mild pulmonary hypertension (PH). Transesophageal echocardiography data suggested the cases of LA spontaneous (echo) contrast and LA appendage flow velocity (LAAFV) ≤ 40 cm/s to be more frequent in G2, in contrast to G1. We revealed the following predictors of SR maintenance after DC cardioversion at 6-months follow-up: higher LV EF (OR 1,07 (95 % CI 1,01–1,13); р=0,021); LAAFV > 40 cm/s (OR 4,33 (95 % CI 1,06–17,78); р=0,042), and less advanced PH (OR 0,24 (95 % CI 0,06–0,93); р=0,038). TTE data from G1 at 6-months follow-up after DC cardioversion suggested the reverse remodeling of both atria (the decrease of LA diameter, LA and right atrium volumes and their indexes). Additionally, G2 demonstrated a worsening in LV systolic function (the rise of LV end-systolic volume and decrease of LV EF), as opposed to G1. Moreover, at 6-months follow-up, G2 patients presented with more advanced severity of PH, as well as mitral and tricuspid regurgitation, in contrast to G1.Conclusions. Better LV systolic function, LAAFV > 40 cm/s and less advanced PH were the predictors of SR maintenance in patients with persistent AF and duration of its episode ≥ 90 days at 6-months follow-up after elective DC cardioversion. The SR maintenance at 6-months follow-up associated with the reverse remodeling of let heart chambers and right atrium. On the contrary, a failure to maintain SR associated with the decrease of LV systolic function, and more advanced PH, mitral and tricuspid regurgitation.
The Teaching Strategy in Reading Comprehension in Grade 2 Students of MtsN Serdang Bedagai
Authors: Panjaitan Khoiriyah , Hariyanto Hariyanto , Hasibuan Ahmad Laut 
Published: September 2023

This research was aimed to figure out the strategies used by English teachers in teaching reading and how they applied the strategies. It was designed as descriptive qualitative research. Participants of the research were two English teachers who taugh the 2 grade the students. Each English teacher had eight meetings observed by the researcher. The research instruments aere strategies checklist and interview. They were used to figure out the strategies used and how the English teachers applied the strategies in teaching reading comprehension. The result of the data were analyzed and broken down into three stages or Data Reduction, Data Display, and Drawing Conclusion or Interpretation. The previous studies showed that the teachers’ strategies were very effective in teaching reading comprehension. On the other hand, the use of too many strategies would affect students’ performances in learning reading comprehension. This reason was contradicted with the conducted the researcher in Junior High School Number 9 Bengkulu. This research showed that the teachers in applying strategies only use two or three strategies. Combination of some strategies was more appropriate comparemany strategies used by the teachers. The students would be more focused if the teacher used fewer strategies but well applied in teaching reading comprehension.
Estimasi Daya dukung Perairan Pesisir Kecamatan Pademawu Kabupaten Pamekasan untuk Kegiatan Budidaya Udang Vannamei Berdasarkan Laju Biodegradasi Limbah
Authors: Ismail Moh , Arisandi Apri , Farid Ahmad 
Published: September 2023

Kegiatan usaha budidaya udang vannamei di Kecamatan Pademawu Kabupaten Pamekasan mengalami peningkatan yang baik hal ini di dukung oleh teknologi budidaya dari tradisional ke intensif selain itu potensi sumber daya alam yang mendukung pengembangan usaha budidaya udang vannamei kedepan memberikan peluang baik bagi pengusaha dan pemilik lahan untuk membuka usaha budidaya udang vannamei baru. Pengembangan usaha budidaya udang vannamei di Kecamatan Pademawu berpotensi mencemari lingkungan perairan, karena Kegiatan usaha budidaya udang vannamei menghasilkan limbah dan limbah dibuang keperairan. Penelitian ini bertujuan untuk mengetahui daya dukung perairan untuk kegiatan usaha budidaya udang vannamei. Penelitian dilakukan pada tanggal 16 April 2021 diperairan Kecamatan Pademawu. Hasil penelitian menunjukkan bahwa volume air yang tersedia selama 1 hari di perairan pesiri pademawu 33.591.227 m3. Jumlah limbah maksimal yang dapat ditampung dalam bentuk TSS (Total Suspendet Solit) adalah 282 ton/hari. kegiatan budidaya udang sistem intensif luasan tambak maksimal 30.56 hektar dengan produksi 575.21 ton/musim tanam. Kegiatan budidaya udang sistem semi intensif luasan tambak maksimal 244.16 hektar dan produksi 624.31 ton/musim tanam. Kegiatan budidaya udang sistem tradisional luasan tambak maksimal 577.87 hektar dan produksi 450.16 ton/musim tanam.
Perlindungan Kepastian Hukum Bagi Penghuni dan Pemilik Satuan Rumah Susun Dalam Pengelolahan Rumah Susun di Jakarta
Authors: Tarsis Liana Tanudjaja 
Published: September 2023

Rumah susun adalah bangunan bertingkat yang di bangun dalam suatu lingkungan dan terbagi dalam bagian-bagian yang distrukturkan secara fungsional dalam arah horizontal maupun vertikal yang merupakan satuan satuan yang masing masing dapat dimiliki dan di gunakan secara terpisah, terutama untuk hunian yang dilengkapi dengan bagian bagian bersama , benda bersama dan tanah bersama yang di atur dalam Undang- Undang No. 20 tahun 2011 Pasal 1. Dalam Pasal 75 ayat 1 Undang-Undang Rumah Susun Pelaku pembangunan atau developer hanya diberikan waktu pengelolaan rumah susun sampai dengan masa transisi, kenyataan yang ada adalah pelaku pembangunan sampai masa transisi itu berakhir masih juga mengelolaannya. Pelaku pembangunan selama masa transisi adalah bekerja sama dan memberikan legalitas sepenuhnya kepada P3SRS untuk membuat hunian sarusun ini lebih nyaman dan baik sehingga adanya perlindungan bagi pemilik dan penghuni satuan rumah susun. Tetapi yang terjadi , pelaku pembangunan selalu intervensi yang berlebihan sehingga membuat posisi P3SRS ini tidak diakui keberadaaan , sehingga membuat pemilik dan penghuni yang sering di rugikan karena adanya dua legalitas yang mana harus dipatuhi. Maka perlunya ketegasan perlindungan hukum untuk Pemilik / Penghuni mendapatkan hunian yang nyaman dan aman.
PERSPEKSTIF AJARAN ISLAM DALAM PRAKTEK PENGHINDARAN PAJAK
Authors: Moeljono Moeljono , Holle Mohammad H 
Published: September 2023

Abstract:This article emphasizes the `perspective` of Islam, towards the practice of tax avoidance. Tax is an obligation for Muslims to the state. However, the practice of tax avoidance is increasingly widespread, even by corporations. So that the state is disadvantaged, because state revenue is reduced from the tax sector which is used for the national development process.This article uses a literature study approach, and the data used is secondary data. The results of this study are that with the practice of tax avoidance, the impacts are, 1. Reduced National Income. 2. Detriment to shareholders, because the returns they receive are smaller than what they should be getting, 3. Hoarding their wealth in certain groups.The practice of tax avoidance, legally does not commit a violation. However, the practice of tax avoidance has done injustice to society and the state. So their norm has been violated. During the punishment of the Prophet Muhammad, those who did not want to pay zakat were punished in the world and the hereafter, while during the time of Caliph Abu Bakar and Caliph Umar Bin Khattab they fought against those who did not pay zakat because they betrayed religion and state.Key Word : Tax Avoidance, Islam, Income, National, Harmful AbstrakArtikel ini menekankan pada `perspekstif` Islam, terhadap praktek penghindaran pajak. Pajak merupakan kewajiban bagi umat Islam kepada negara. Namun, praktik penghindaran pajak semakin marak, bahkan dilakukan oleh korporasi. Sehingga negara dirugikan, karena penerimaan negara berkurang dari sektor pajak yang digunakan untuk proses pembangunan nasional.Artikel ini menggunakan pendekatan studi kepustakaan, dan data yang digunakan data sekunder. Hasil dari kajian ini adalah dengan adanya praktek penghindaran pajak maka dampak yang ditimbulkan adalah, 1. Berkurangnya Pendapatan Nasional. 2. Merugikan pemegang saham, karena return yang diterimanya lebih kecil dari yang seharusnya didapat, 3. Menimbun kekayaannya pada kelompok tertentu.Praktek penghindaran pajak, secara hukum tidak melakukan pelanggaran. Namun, praktek penghindaran pajak telah melakukan ketidakadilan terhadap masyarakat dan negara. Jadi norma mereka telah melakukan pelanggaran. Pada masa hukuman Rasulullah SAW bagi orang yang tidak mau membayar zakat mendapat hukuman dunia dan akherat, sedangkan pada masa Khalifah Abu Bakar dan Khalifah Umar Bin Khattab mereka memerangi bagi yang tidak membayar zakat karena mengkhianati agama dan negara.Kata Kunci: Penghindaran Pajak, Islam, Pendapatan, Nasional, Merugikan
Drug-loaded hybrid hydrogels for sonodynamic-chemodyanmic therapy and tumor metastasis suppression
Authors: Wang Xiaoying , Zhu Liyun , Zhou Jianhui , Zhao Lingzhou , Li Jingchao , Liu Changcun 
Published: September 2023

Introduction: Although various therapies have been adopted to treat cancer, metastasis of tumor cells still is a big challenge that compromises therapeutic benefits.Methods: We herein report an injectable drug-loaded hybrid hydrogel that can achieve sonodynamic therapy (SDT) and chemodyanmic therapy (CDT) combined action and suppression of tumor metastasis. This alginate (ALG)-based hydrogel (termed as AMPS) contains manganese dioxide (MnO2) nanoparticles as the CDT agents, an organic polymer as the sonosensitizer, and a SIS3 drug as metastasis inhibitor.Results: AMPS is formed via the chelation of ALG by Ca2+ in tumor microenvironment, in which MnO2 nanoparticles mediate CDT via Fenton-like reaction and the organic polymers enable SDT under ultrasound (US) irradiation by generating singlet oxygen (1O2), allowing for combinational action of CDT and SDT. In addition, SIS3 is released from AMPS hydrogels to inhibit the metastasis of tumor cells. As such, the AMPS enables a combinational action of SDT and CDT to greatly inhibit the growths of subcutaneous tumors in living mice and also completely suppress the tumor metastasis in lungs and livers.Conclusion: This study thus offers a hybrid hydrogel platform for combinational therapy and metastasis suppression simultaneously.
Hypertension evaluated in the public and private Brazilian health system hypertension in public and private service
Authors: Amorim Kecia C. F. O. , Vitorino Priscila Valverde O. , Feitosa Audes D. M. , Santos Mayara Cedrim , Bezerra Rodrigo , Lopes Lais Rocha , Camafort Miguel , Coca Antonio , Sousa Ana Luíza Lima , Barroso Weimar K. S. 
Published: September 2023

IntroductionHypertension (HT) remains the leading cause of death worldwide. In Brazil it is estimated that 35% of the adult population has HT and that about 20% of these have blood pressure values within the targets recommended for the reduction of cardiovascular risk. There are some data that point to different control rates in patients treated by cardiologists in public and private referral center and this is an important point to be investigated and discussed.ObjectiveTo compare sociodemographic characteristics, body mass index (BMI), antihypertensive (AH) drugs, blood pressure (BP) and control rate in public (PURC) and private (PRRC) referral centers.MethodologyA cross-sectional multicenter study that analyzed data from hypertensive patients assisted by the PURC (one in Midwest Region and other in Northeast region) and PRRC (same distribution). Variables analyzed: sex, age, BMI, classes, number of AH used and mean values of systolic and diastolic BP by office measurement and home blood pressure measurement (HBPM). Uncontrolled hypertension (HT) phenotypes and BP control rates were assessed. Descriptive statistics and χ2 tests or unpaired t-tests were performed. A significance level of p &lt; 0.05 was considered.ResultsA predominantly female (58.9%) sample of 2.956 patients and a higher prevalence of obesity in PURC (p &lt; 0.001) and overweight in PRRC (p &lt; 0.001). The mean AH used was 2.9 ± 1.5 for PURC and 1.4 ± 0.7 for PRRC (p &lt; 0.001). Mean systolic and diastolic BP values were higher in PURC as were rates of uncontrolled HT of 67.8% and 47.6% (p &lt; 0.001) by office measurement and 60.4% and 35.3% (p &lt; 0.001) by HBPM in PURC and PRRC, respectively.ConclusionPatients with HT had a higher prevalence of obesity in the PURC and used almost twice as many AH drugs. BP control rates are worse in the PURC, on average 15.3 mmHg and 12.1 mmHg higher than in the PRRC by office measurement.
The safety and efficacy of direct oral anticoagulants among chronic kidney disease patients on dialysis with non-valvular atrial fibrillation: a meta-analysis
Authors: Mapili Jerahmeel Aleson L. , Lim Lloyd Christopher S. , Velando Bianca M. , Aherrera Jaime Alfonso M. 
Published: September 2023

BackgroundIndividuals with chronic kidney disease (CKD) on dialysis are at an increased risk of stroke and embolic events especially in the presence of atrial fibrillation (AF). Vitamin K antagonists (VKA), including warfarin, have been used for decades for anticoagulation among CKD patients on dialysis with AF but recent evidence has shown increased bleeding. Direct oral anticoagulants (DOAC) have been emerging as an alternative to VKA which, based on several observational cohort studies, are at least as efficacious and safe as VKA. This meta-analysis looked into the safety and efficacy of DOACs compared to VKA among CKD patients on dialysis with non-valvular AF.MethodologyThis study used a random-effects meta-analysis using RevMan 5.4. PubMed, EMBASE, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, and ClinicalTrials.gov were searched from their dates of inception to June 2023. The risk of bias was assessed using Cochrane RoB2 and the certainty of evidence was assessed using GRADE.ResultsThis meta-analysis showed that DOACs when compared to VKA have no significant difference in terms of risk for major bleeding (RR = 0.81, 95% CI 0.46–1.43), ischemic stroke (RR = 0.5, 95% CI 0.19–1.35), and cardiovascular death (RR = 1.34, 95% CI 0.69–2.60).DiscussionThis meta-analysis adds to the growing body of evidence supporting that the use of DOACs has similar efficacy and safety outcomes in CKD patients on dialysis with non-valvular AF patients compared to VKA. The findings need to be replicated in larger and more adequately powered clinical trials in order to ascertain its level of evidence.
A new assemblage of late Neanderthal remains from Cova Simanya (NE Iberia)
Authors: Morales Juan I. , Cebrià Artur , Soto María , Rodríguez-Hidalgo Antonio , Hernando Raquel , Moreno-Ribas Elena , Lombao Diego , Rabuñal José R. , Martín-Perea David M. , García-Tabernero Antonio , Allué Ethel , García-Basanta Andrea , Lizano Esther , Marquès-Bonet Tomàs , Talamo Sahra , Tassoni Laura , Lalueza-Fox Carles , Fullola Josep M. , Rosas Antonio 
Published: September 2023

This study presents an exceptional collection of 54 Late Pleistocene human remains that correspond to at least three Neanderthal individuals from Simanya Gran, the main gallery of Cova Simanya, located in the northeastern Iberian Peninsula. The collection comprised 53 unpublished remains that were unearthed during the 1970s and an additional tooth discovered during 2021 excavations. The specimens represent an adult with a small stature, a periadolescent aged approximately 11.5 years, and an immature individual aged approximately 7.7 years, thus offering a more complete demographic perspective. The collection encompasses diverse anatomical parts including upper and lower dentition, mandible, vertebrae, and limb bones from both the upper and lower extremities. Attempts to extract aDNA were unsuccessful. Renewed archaeological investigations at Cova Simanya have facilitated the reevaluation of the original stratigraphic context of these remains, leading to the discovery of the additional tooth, aligning with the periadolescent individual. This assemblage is currently the most extensive Neanderthal collection from the northeastern Mediterranean Iberia, offering invaluable insights into the morphology and evolutionary trajectory of Late Pleistocene hominins. Hence, Simanya Neanderthals will enhance our understanding of Neanderthal demographics and evolution, paving the way for an in-depth examination of the morphological diversity and evolutionary context of Iberian Neanderthals.
“Wait, I can’t do that anymore!”: pandemic teacher immediacy in college communication classes
Authors: Chatham-Carpenter April , Malone Michelle 
Published: September 2023

IntroductionThe stress and strain due to various aspects of the pandemic affected teaching and learning. Relating between instructors and students, and between students, may never be the same. Adjustments to teaching and learning may still need to be made due to the lingering effects of the pandemic, especially as zoom classrooms continue to be used within communication and other disciplines.MethodsIn this study, the researchers interviewed 15 communication instructors, using indepth semi-structured zoom interviews, about their experiences in the pandemic classroom and how they attempted to build relationships and connections with students during the COVID-19 pandemic.ResultsThe researchers found specific immediacy strategies used by instructors, with participants indicating they attempted to use the more traditional teacher nonverbal immediacy behaviors such as eye contact, facial expressions, physical distance, and touch, but were hampered by the wearing of masks, practicing social distancing, and moving to online teaching modalities where student engagement was limited at best. Instructors also adapted verbal immediacy behaviors, as they used various strategies for inviting participation, providing feedback, and being real to develop connections with students, as well as building in specific teaching structures into their pandemic classrooms. In addition, participants indicated they used a variety of additional immediacy-related strategies and behaviors to build relationships once moving to blended HyFlex or online teaching. These strategies were used consistently, as instructors seamlessly moved between the online synchronous classroom, the blended classroom, and the face-to-face classroom with masking and physical distancing required.DiscussionOur research revealed that there were unique ways relationships were built, typically using different types of media to enact teacher immediacy in nuanced ways. We argue that looking at such teaching using both media multiplexity and embodied pedagogy perspectives can enhance the teacher immediacy literature by demonstrating how teacher immediacy was changed during the pandemic, as media richness increased the likelihood of developing relationships between teachers and students through an embodied pedagogy of caring using technological tools.
Radiomics optimizing the evaluation of endometrial receptivity for women with unexplained recurrent pregnancy loss
Authors: Huang Wendi , Jin Yi , Jiang Lulu , Liang Mengjie 
Published: September 2023

BackgroundThe optimization of endometrial receptivity (ER) through individualized therapies has been shown to enhance the likelihood of successful gestation. However, current practice lacks comprehensive methods for evaluating the ER of patients with recurrent pregnancy loss (RPL). Radiomics, an emerging AI-based technique that enables the extraction of mineable information from medical images, holds potential to offer a more objective and quantitative approach to ER assessment. This innovative tool may facilitate a deeper understanding of the endometrial environment and enable clinicians to optimize ER evaluation in RPL patients.ObjectiveThis study aimed to identify ultrasound radiomics features associated with ER, with the purpose of predicting successful ongoing pregnancies in RPL patients, and to assess the predictive accuracy of these features against regular ER parameters.MethodsThis retrospective, controlled study involved 262 patients with unexplained RPL and 273 controls with a history of uncomplicated full-term pregnancies. Radiomics features were extracted from ultrasound endometrial segmentation images to derive a radiomics score (rad-score) for each participant. Associations between rad-scores, baseline clinical variables, and sonographic data were evaluated using univariate and multivariate logistic regression analyses to identify potential indicators of RPL. Receiver operating characteristic (ROC) curve analysis was performed to evaluate the predictive accuracy of the rad-score and other identified indicators in discriminating RPL cases. Furthermore, the relationships between age and these identified indicators were assessed via Pearson correlation analysis.ResultsFrom the 1312 extracted radiomics features, five non-zero coefficient radiomics signatures were identified as significantly associated with RPL, forming the basis of the rad-score. Following multivariate logistic regression analysis, age, spiral artery pulsatility index (SA-PI), vascularisation index (VI), and rad-score emerged as independent correlates of RPL (all P&lt;0.05). ROC curve analyses revealed the superior discriminative capability of the rad-score (AUC=0.882) over age (AUC=0.778), SA-PI (AUC=0.771), and VI (AUC=0.595). There were notable correlations between age and rad-score (r=0.275), VI (r=-0.224), and SA-PI (r=0.211), indicating age-related variations in RPL predictors.ConclusionThis study revealed a significant association between unexplained RPL and elevated endometrial rad-scores during the WOI. Furthermore, it demonstrated the potential of rad-scores as a promising predictive tool for successful ongoing pregnancies in RPL patients.