bluuebunny/crossref_metadata_2025_split huggingface dataset:
Who is lost to follow‐up in HIV care? Assessment of care retention over time and the impact of COVID‐19. Longitudinal analysis of the PISCIS cohort
Authors: Palacio‐Vieira Jorge , Moreno‐Fornés Sergio , Díaz Yesika , Aceitón Jordi , Bruguera Andreu , Nomah Daniel K. , Llibre Josep M. , Knobel Hernando , Chivite Iván , Miro José M. , Domingo Pere , Suanzes Paula , Fanjul Francisco , Navarro Gemma , Macorigh Lizza , Mera Arantzazu , Casabona Jordi , Imaz Arkaitz , Reyes‐Urueña Juliana ,   PISCIS study group
Published: March 2023

AbstractIntroductionPeople living with HIV who are lost to follow‐up have a greater risk of health deterioration, mortality, and community transmission.ObjectiveOur aim was to analyse both how rates of loss to follow‐up (LTFU) changed between 2006 and 2020 and how the COVID‐19 pandemic affected these rates in the PISCIS cohort study of Catalonia and the Balearic Islands.MethodsWe analysed socio‐demographic and clinical characteristics of LTFU yearly and with adjusted odds ratios to assess the impact of these determinants on LTFU in 2020 (the year of COVID‐19). We used latent class analysis to categorize classes of LTFU based on their socio‐demographic and clinical characteristics at each year.ResultsIn total, 16.7% of the cohort were lost to follow‐up at any time in the 15 years (n = 19 417). Of people living with HIV who were receiving follow‐up, 81.5% were male and 19.5% were female; of those who were lost to follow‐up, 79.6% and 20.4% were male and female, respectively (p < 0.001). Although rates of LTFU increased during COVID‐19 (1.11% vs. 0.86%, p = 0.024), socio‐demographic and clinical factors were similar. Eight classes of people living with HIV who were lost to follow‐up were identified: six for men and two for women. Classes of men (n = 3) differed in terms of their country of birth, viral load (VL), and antiretroviral therapy (ART); classes of people who inject drugs (n = 2) differed in terms of VL, AIDS diagnosis, and ART. Changes in rates of LTFU included higher CD4 cell count and undetectable VL.ConclusionsThe socio‐demographic and clinical characteristics of people living with HIV changed over time. Although the circumstances of the COVID‐19 pandemic increased the rates of LTFU, the characteristics of these people were similar. Epidemiological trends among people who were lost to follow‐up can be used to prevent new losses of care and to reduce barriers to achieve Joint United Nations Programme on HIV/AIDS 95‐95‐95 targets.
Droplet digital polymerase chain reaction improves the detection of BCR‐ABL1 kinase domain mutation in Philadelphia chromosome‐positive acute lymphoblastic leukemia
Authors: Wan Li , Ma Jiao , Gong Xiaoyuan , Li Qinghua , Wang Ying , Wei Hui , Wang Jianxiang , Xiao Zhijian , Mi Yingchang 
Published: March 2023

AbstractIntroductionSanger sequencing (SS) is the most frequently used method for detecting ABL1 kinase domain (KD) mutations in patients with Philadelphia chromosome‐positive acute lymphoblastic leukemia (Ph+ ALL). However, it cannot detect low levels of mutation. Recently, droplet digital polymerase chain reaction (ddPCR) has been developed as a sensitive technique for detecting mutations in hematological neoplasms. The aim of our study was to explore the value of ddPCR in detecting ABL1 KD mutations.MethodsWe compared the results of SS and ddPCR in detecting ABL1 KD mutations in a consecutive cohort of 65 adolescent and adult patients with Ph+ ALL treated with intensive multiagent chemotherapy plus TKIs.ResultsAt diagnosis, SS and ddPCR identified 1 (1.5%) and 26 (40%) out of 65 patients with positive ABL1 KD mutations, respectively. Patients with T315I mutations detected by ddPCR at diagnosis all developed SS‐detectable T315I mutations during treatment with first‐ or second‐generation TKIs, and non‐T315I mutations detected by ddPCR at diagnosis displayed a limited prognostic impact.ConclusionOur study demonstrates that ddPCR is a highly sensitive and accurate mutation detection method and the presence of T315I mutations before treatment shows prognostic significance in the context of first‐ or second‐generation TKIs.
Survey of parents of children with intellectual disabilities and/or autism who experience chronic constipation
Authors: Rooney James , Hodge Rebecca , Smith Jade , Vanstone Kelly , Laugharne Richard , Shankar Rohit 
Published: March 2023

AbstractBackgroundConstipation is common in children with intellectual disabilities and/or autism, but poorly researched. This study looks to understand parental knowledge, attitudes and management practices towards constipation in children with intellectual disabilities and/or autism.MethodsA cross‐sectional online survey developed with patient facing organisations was circulated to parents of children with intellectual disabilities and/or autism using an exponential and non‐discriminatory snowballing method for recruitment. A smaller sample were purposively sampled for their in‐depth experiences.ResultsOf 68 responses, people were open to discussing constipation and knowledgeable about risk factors. In the qualitative interviews, of 15 parents, they wanted to be treated as an expert in their child's care. They desired a service that was more responsive when in difficulty. While wanting more information about medication options, parents want a more holistic approach.ConclusionsServices need more emphasis on holistic management. Listening to parents and treating them as experts is important.
Academic discourse and peer collaboration in online high school learning environments
Authors: Douglas Sara , Slusser Emily , Felton Mark 
Published: March 2023

AbstractBackgroundDialogic engagement is instrumental in promoting higher‐order thinking, motivation, and learning. Despite their dramatic uptake in the US in the past decade, there is limited evidence that online high school courses offer sufficient opportunities for students to communicate and collaborate with teachers and peers.ObjectivesThis two‐part study explores teacher perspectives and the experiences of students in online learning environments to determine if, how, and why students engage in two forms of dialogic engagement–academic discourse and peer collaboration.MethodsTo identify the extent to which teachers perceive academic discourse and peer collaboration to be valuable and feasible in online learning environments, Study 1 surveyed educators and advisors of online learning programs (n = 49). To determine whether these perspectives align with student experiences, Study 2 included a series of over‐the‐shoulder observations of five high school students engaging in their online coursework.Results and ConclusionsFindings reveal a disconnect between best practices in education and reality. Online teachers report that academic discourse is valuable and feasible, but also detail several challenges to successful implementation in online coursework. At the same time, direct observations of high school students indicate that they rarely, if ever, engage in peer collaboration and academic discourse activities.Major TakeawaysAlthough valued as a means to improve educational outcomes, opportunities for dialogic engagement are not translating to online learning environments. The solution is to develop curriculum, policies, and procedures that centre on meaningful integration of dialogic activities, motivating students to engage.
Overview of growth differentiation factor 15 in metabolic syndrome
Authors: Asrih Mohamed , Wei Shibo , Nguyen Thanh T. , Yi Hyon‐Seung , Ryu Dongryeol , Gariani Karim 
Published: March 2023

AbstractGrowth and differentiation factor 15 (GDF15) is a member of the transforming growth factor‐β (TGF‐β) superfamily. GDF15 has been linked with several metabolic syndrome pathologies such as obesity and cardiovascular diseases. GDF15 is considered to be a metabolic regulator, although its precise mechanisms of action remain to be determined. Glial cell‐derived neurotrophic factor family receptor alpha‐like (GRAL), located in the hindbrain, has been identified as the receptor for GDF15 and signals through the coreceptor receptor tyrosine kinase (RET). Administration of GDF15 analogues in preclinical studies using various animal models has consistently been shown to induce weight loss through a reduction in food intake. GDF15, therefore, represents an attractive target to combat the current global obesity epidemic. In this article, we review current knowledge on GDF15 and its involvement in metabolic syndrome.
The impact of dupilumab on skin barrier function: A systematic review
Authors: Montero‐Vilchez Trinidad , Sanabria‐de‐la‐Torre Raquel , Sanchez‐Diaz Manuel , Ureña‐Paniego Clara , Molina‐Leyva Alejandro , Arias‐Santiago Salvador 
Published: March 2023

AbstractSkin barrier dysfunction plays an important role in atopic dermatitis (AD) aetiopathogenesis. Dupilumab, a drug that inhibits IL‐4 and IL‐13, is an effective treatment for AD but there is scarce evidence about its impact on epidermal barrier. The objective of this systematic review is to evaluate the influence of dupilumab on skin barrier in patients with AD using non‐invasive tools. A systematic review was designed following PRISMA guidelines. The literature search identified 73 references and, finally, only 6 were selected, including a total of 233 participants. All the studies were prospective observational studies. Dupilumab improved clinical scores in all the research. Skin barrier function parameters were mainly measured on the volar forearm. Transepidermal water loss (TEWL) was the parameter most frequently measured, evaluated in all the studies. Dupilumab decreased TEWL on eczematous lesions and non‐involved skin. About 33.6% (2/6) studies reported that dupilumab also increased stratum corneum hydration (SCH) on eczematous lesions while one study did not report any changes in this parameter. This drug also decreased temperature and improved ceramide composition. In conclusion, dupilumab improved skin barrier function in AD patients, mainly reflected in a decreased in TEWL values.
Flood risk in Kuala Lumpur, Malaysia: A consideration of flood defences in a broadscale hydraulic model
Authors: Massam Ashleigh , Smith Helen , Filipova Valeriya , Waller Simon , Muhamad Nurfashareena , Pereira Joy Jacqueline 
Published: March 2023

AbstractA novel approach to consider local‐scale defence infrastructure in an urban environment, coupled with a broadscale hydraulic model framework, is applied to the capital city of Kuala Lumpur, Malaysia. Broadscale hydraulic modelling frameworks are often able to employ more complex models, but are typically limited to homogenous decision‐making to ensure standardised outputs across large regions. Conversely, small‐scale hydraulic modelling frameworks tend to better integrate local‐scale features but can be computationally expensive to scale up beyond a regional view. Improvements to the broadscale hydraulic model framework through the incorporation of defence systems yield a more accurate representation of fluvial flood risk. This study incorporates defences in Kuala Lumpur, yielding a reduction in our estimates of fluvial flood extent by around 40%. The results of this study are validated against a set of high‐quality observations, demonstrating the capability of the model framework in capturing flood risk in more than 95% of known flood risk zones in the city. Incorporating defence infrastructure using data‐driven decision making and existing functionality in the hydraulic model could be automated in future model builds. This new approach bridges the gap between local‐scale model frameworks and the broadscale, homogenous 2D hydraulic modelling studies.
Association between the nurse work environment and patient experience in Chilean hospitals: A multi‐hospital cross‐sectional study
Authors: Simonetti Marta , Aiken Linda H. , Lake Eileen T. 
Published: March 2023

AbstractIntroductionInternational evidence shows that nurses' work environments affect patient outcomes, including their care experiences. In Chile, several factors negatively affect the work environment, but they have not been addressed in prior research. The aim of this study was to measure the quality of the nurse work environment in Chilean hospitals and its association with patient experience.DesignA cross‐sectional study of 40 adult general high‐complexity hospitals across Chile.MethodsParticipants included bedside nurses (n = 1632) and patients (n = 2017) in medical or surgical wards, who responded to a survey. The work environment was measured through the Practice Environment Scale of the Nursing Work Index. Hospitals were categorized as having a good or poor work environment. A set of patient experience outcomes were measured through the Hospital Consumer Assessment of Healthcare Providers and Systems (HCAHPS) survey. Adjusted logistic regression models were used to test associations between the environment and patient experiences.ResultsFor all outcomes, the percentage of patients satisfied was higher in hospitals with good as compared to poor work environments. In good environment hospitals patients had significantly higher odds of being satisfied with communication with nurses (OR 1.46, 95% CI: 1.10–1.94, p = 0.010), with pain control (OR 1.52, 95% CI: 1.14–2.02, p = 0.004), and with nurses' timely responses in helping them to go to the bathroom (OR 2.17, 95% CI: 1.49–3.16, p < 0.0001).ConclusionsHospitals with good environments outperform hospitals with poor environments in most patient care experience indicators. Efforts to improve nurses' work environment hold promise for improving patient experiences in Chilean hospitals.Clinical RelevanceHospital administrators and nurse managers should value, especially in the context of financial constraints and understaffing, the implementation of strategies to improve the quality of nurses´ work environments so that they can provide patients with a better care experience.
Cheek wrinkles revisited: Etiological classifications and nonsurgical treatment options
Authors: Peng Jui‐Hui , Peng Hsien‐Li Peter 
Published: March 2023

AbstractBackgroundWrinkles are one of the key signs of an aging face. Cheek wrinkles have a prominent negative impact on facial aesthetic. Recognizing the pathology and types of different cheek wrinkles, and the possible minimal invasive interventions to treat them, are crucial for optimal aesthetic outcome.ObjectiveThe classification of cheek wrinkles based on etiology, past literature, and wrinkle pattern, and the outlining of possible treatment options.ResultFive different types of cheek wrinkles are described: Type 1‐Atrophic cheek wrinkles, Type 2‐dynamic expressional cheek wrinkles, Type 3‐static expressional cheek wrinkles, Type 4‐laxity cheek wrinkles, and Type 5‐sleep cheek wrinkles. Treatment options and techniques for different types of cheek wrinkles are recommended accordingly.
Imaging of the peripheral nervous system in nociplastic pain: An ultrasound study in patients with fibromyalgia
Authors: Di Carlo Marco , Bianchi Benedetta , Cipolletta Edoardo , Farah Sonia , Filippucci Emilio , Salaffi Fausto 
Published: March 2023

AbstractBackground and PurposeAlthough fibromyalgia (FM) is considered a central sensitization syndrome, studies investigating peripheral nerves in this condition are not available. The primary objective of this study is to investigate the sonographic changes (ie, increased cross‐sectional area [CSA]), of peripheral nerves in patients with FM compared to healthy controls. The secondary objective is to identify potential clinical correlations associated with increased CSA in patients with FM.MethodsIn this cross‐sectional observational study, consecutive female patients with FM underwent sonographic assessment using a standardized scanning protocol. The CSA of seven nerves was measured bilaterally at 11 anatomic sites by an experienced sonographer. Differences in CSA of nerves were compared with those of healthy subjects by one‐way analysis of variance. Patients underwent clinimetric evaluation aimed at investigating disease severity, neuropathic pain features, depression, anxiety, fatigue, and autonomic symptoms to explore the possible correlation between CSA and clinical features.ResultsForty‐seven patients and 20 healthy controls were enrolled. Differences in terms of increased CSA between patients and healthy controls were identified at multiple levels, mainly at the level of the sural nerve, vagus nerve, and sixth cervical nerve root (for all, p < .001). Sonographic findings, however, did not correlate with the clinical features explored.ConclusionsPatients with FM show higher CSA of nerves than healthy subjects. The increased CSA is most evident at the sural nerve, vagus nerve, and sixth cervical nerve root. Ultrasound, a relatively easy‐to‐use technique, could identify morphological changes, in peripheral nervous structures in patients with FM.
Prognostic value of pulmonary vascular resistance estimated by echocardiography in dogs with myxomatous mitral valve disease and pulmonary hypertension
Authors: Yuchi Yunosuke , Suzuki Ryohei , Yasumura Yuyo , Saito Takahiro , Teshima Takahiro , Matsumoto Hirotaka , Koyama Hidekazu 
Published: March 2023

AbstractBackgroundProgression to combined post‐ and pre‐capillary pulmonary hypertension (PH) provides prognostic information in human patients with post‐capillary PH. Pulmonary vascular resistance estimated by echocardiography (PVRecho) is useful for the stratification of dogs with myxomatous mitral valve disease (MMVD) and detectable tricuspid regurgitation.ObjectivesTo evaluate the prognostic value of PVRecho in dogs with MMVD.AnimalsFifty‐four dogs with MMVD and detectable tricuspid regurgitation.MethodsProspective cohort study. All dogs underwent echocardiography. The PVRecho was calculated based on tricuspid regurgitation and the velocity‐time integral of the pulmonary artery flow. To evaluate the influence of echocardiographic variables on cardiac‐related deaths, Cox proportional hazard analysis was performed. Additionally, Kaplan‐Meier curves classified by PVRecho tertiles were made and compared using log‐rank tests to evaluate the influence of PVRecho on all‐cause mortality and cardiac‐related death.ResultsThe median follow‐up time was 579 days. Forty‐one dogs with MMVD (PH severity [number]: no or mild, 21/33; moderate, 11/11; severe, 9/10) died during the study. In the multivariable Cox proportional hazard analysis adjusted for age, sildenafil administration, and American College of Veterinary Internal Medicine stage of MMVD, left atrial to aortic diameter ratio and PVRecho remained significant (adjusted hazard ratio [95% confidence interval]: 1.2 [1.1‐1.3] and 2.1 [1.6‐3.0], respectively). Higher PVRecho showed a significant association with lower survival rates.Conclusions and Clinical ImportanceLeft atrial enlargement and high PVRecho were independent prognostic factors in dogs with MMVD and detectable tricuspid regurgitation.
Parent Involvement with Their Children's Schools: Perceptions of Saudi Parents of Elementary School Students with Learning Disabilities
Authors: Abed Mohaned G. , Shackelford Todd K. 
Published: March 2023

AbstractThis exploratory, qualitative study investigated the perceptions of Saudi Arabian parents of elementary school‐aged children with learning disabilities with regard to their involvement in their children's education. Guided by results of previous research conducted primarily with Western samples, and using a semistructured interview methodology followed by thematic phenomenological analyses, specific interview topics included parental perceptions of (a) the importance of parent–school partnerships, (b) the means of encouraging a parent–school relationship, and (c) how school practices may affect parental participation. The study involved 13 parents of children in elementary education (ages 7–12 years) diagnosed with learning disabilities. The results suggest several ways to overcome the involvement barriers reported by parents.
Anatomic outcomes of sacrohysteropexy without posterior mesh placement in patients with asymptomatic grade 1 and 2 rectoceles: Is a rectouterine mesh really necessary?
Authors: Sancı Adem , Obaid Khaled , Topcuoglu Murat , Gokce Mehmet İlker , Süer Evren , Gülpinar Ömer 
Published: March 2023

AbstractObjectivesTo present the anatomic outcomes of sacrohysteropexy surgery without posterior mesh placement in patients with asymptomatic grade 1 and 2 rectoceles.MethodsThe patients who underwent abdominal sacrohysteropexy without posterior mesh placement for the treatment of symptomatic grade 3 and 4 anterior/apical prolapse + asymptomatic grade 1 and 2 rectocele between May 2015 and January 2021 were evaluated retrospectively. The success rate, the anatomic outcomes (for anterior, apical, and posterior pelvic organ prolapse [POP]), and perioperative data of the surgical procedure were assessed. The objective failure criteria after surgery included the presence of grade 1 or higher in any compartment (anatomical criteria), recurrent POP requiring an operation, and/or usage of pessaries. Perioperative adverse events were categorized according to the Clavien–Dindo classification.ResultsFifty‐one patients underwent sacrohysteropexy without posterior mesh. The mean age of the patients was 56.8 ± 10 years. The success rates (anatomical outcomes) for the anterior/apical and posterior POP in the study group were 60.7%, 54.9%, and 58.8%, respectively, at a median follow‐up time of 40.24 (24–71) months. The median hospital stay was 3.1 (2–6) days. The mean estimated blood loss was 127.6 (80–150) mL. The mean operation time was 114 (90–156) min. The mean urethral and catheter removal times were 1.3 (1, 2) and 2.1 (2–4) days, respectively. The mean recovery time of gastrointestinal motility was 14.4 h (11–35).ConclusionsSacrohysteropexy without posterior mesh placement might be associated with less pain, shorter operative time, and shorter recovery time of gastrointestinal motility, without compromising the anatomic success.
Not All Citations Are Equal: Reflections from Medical Anthropology in the Philippines
Authors: Lasco Gideon 
Published: March 2023

AbstractLong before recent calls to decolonize anthropology, practitioners of “national anthropologies”—such as local anthropologists from/in/of the Philippines—have sought to implement a more inclusive kind of scholarship, and this has been reflected in their citational practices. Indeed, a look at the scholarly output of Philippine anthropologists would show a diverse set of citations that feature local scholarship, including those written in Filipino. As I will show in this article, however, not all citations are equal. Theoretical and methodological citations are typically drawn from Euro‐American scholars while scholarship from the Global South is typically invoked as illustrative examples, as parallels, and to set context. Such citational practices, I argue, are a consequence of particular disciplinary histories and divergent priorities. They reinforce the inequalities of power and academic capital within medical anthropology, raising the need for more reflexivity not just about whom medical anthropologists cite but for what reasons.
“Acquired” Equals Addition? Associating Verbs with Arithmetic Operations Impacts Word Problem Performance
Authors: Jaffe Joshua Benjamin , Gharibani Troy , Bolger Donald Joseph 
Published: March 2023

AbstractSuccessful word problem performance often requires understanding the linguistic relations between characters and objects. However, the keyword method promotes associating specific words with mathematical operations while neglecting the situational context. Research has thoroughly investigated the detrimental effects of individuals associating relational terminology (e.g., “more”) with mathematical operations (e.g., “addition”). The current study expands upon this line of research by examining whether undergraduate students associate verbs with mathematical operations and if verbal associations affect word problem performance. Similar to relational terminology, the participants associated verbs with operations, which significantly impacted performance. The educational implications are discussed.