bluuebunny/crossref_metadata_2025_split huggingface dataset:
Global Prevalence of Mental Health Problems Among Cancer Survivors: A Meta‐Analysis From 31 Countries
Authors: Ge Meng‐Wei , Sheng Jun , Shen Lu‐Ting , Hu Fei‐Hong , Jia Yi‐Jie , Ur‐Rehman Attiq , Li Wei , Lan Jian‐Zeng , Liu Peng , Chen Hong‐Lin 
Published: January 2025

ABSTRACTBackgroundWith the improvement of medical treatment, the survival rate of cancer patients continues to rise; however, their psychological issues require further management. Currently, there is uncertainty regarding the prevalence of mental health problems among cancer survivors.ObjectiveTo quantitatively summarize the global prevalence of mental health problems in cancer survivors.MethodsWe searched CINAHL, PsychlNFO, Embase, Web of Science, and PubMed for studies reporting the prevalence of various mental health problems in cancer survivors who have survived at least 3 months. Subsequently, stratified analyses were conducted based on study design, region, cancer system, and time since diagnosis. Moreover, meta‐regression was utilized to investigate sources of heterogeneity. We used Rstudio software 4.3.0, Stata 17.0 software and metaprop package.ResultsA total of 147 studies involving 135,015 cancer survivors from over 30 countries were identified, primarily focusing on six mental health problems. Among 78 studies addressing anxiety, the prevalence was 24.4% (95% CI: 20.2%–28.8%). Among the 96 studies on depression, the prevalence was 23.7% (95% CI: 20.1%–27.4%). In the case of sleep disorders, 42 studies reported a prevalence of 34.1% (95% CI: 27.9%–40.6%). The overall prevalence decreased over time since diagnosis. Most of the analyzed data exhibited significant heterogeneity (I2 > 75%).ConclusionThe analysis indicated that cancer survivors experience a diverse range of mental health problems, which were prevalent among them. The results emphasized the importance of recognizing and treating mental health problems in cancer survivors and served as a reminder for healthcare workers to address mental health problems in this population. The registration number was CRD42023466209.
Upper Extremity Exercise Capacity and Muscle Oxygenation in Patients With Primary Ciliary Dyskinesia
Authors: Mutlu Şeyma , Boşnak Güçlü Meral , Şişmanlar Eyüboğlu Tuğba , Aslan Ayşe Tana 
Published: January 2025

ABSTRACTBackground and ObjectivesPatients with primary ciliary dyskinesia (PCD) have a reduction in exercise capacity from the early stages. Although there are studies investigating these patients' lower extremity exercise capacity using various methodologies, there needs to be more research on the functional exercise capacity of the upper extremities. This study aimed to compare pulmonary function, upper extremity functional exercise capacity, muscle oxygenation, muscle strength, and physical activity level in children with PCD and controls.MethodsTwenty‐seven children with PCD and 26 controls were included. Pulmonary function (spirometry), upper extremity functional exercise capacity (6‐min pegboard and ring test (6PBRT), muscle oxygenation (Moxy device), deltoid muscle strength (dynamometer), and physical activity level (metabolic holter) were assessed.ResultsPatients' FVC%, FEV1%, FEV1/FVC, PEF%, FEF25%–75%, deltoid muscle strength (%) were statistically decreased compared with controls (p < 0.05). The 6PBRT ring count, deltoid muscle oxygen saturations, and total hemoglobin levels were similar in both groups (p > 0.05).DiscussionPulmonary function deteriorates and upper extremity muscle strength decreases in children with PCD. The upper extremity exercise capacity of these patients remains preserved. However, upper extremity resting muscle oxygen saturation is lower in children compared to healthy children. Most patients and healthy children are inactive. The upper extremity exercise capacity possibly declines due to deteriorating pulmonary function as the patients get older, which needs to be investigated routinely. Both upper‐lower extremity aerobic exercise training applied consistently and physical activity counseling as part of their pulmonary rehabilitation program should be considered in children with PCD.
Introduction of Ivacaftor/Lumacaftor in Children With Cystic Fibrosis Homozygous for F508del in the Netherlands: A Nationwide Real‐Life Study
Authors: Zwitserloot A. M. , Aziz S. Z. , Chen Y. , Bannier M. A. G. E. , Janssens H. M. , Merkus P. F. J. M. , Nuijsink M. , Terheggen‐Lagro S. W. J. , Tiddens H. A. W. M. , Zomer‐ van Ommen D. D. , Vonk J. M. , de Winter‐ de Groot K. M. , Willemse B. W. M. , Koppelman G. H. 
Published: January 2025

ABSTRACTIntroductionLumacaftor/ivacaftor (lum/iva) was introduced in the Netherlands in 2017. We investigated 1‐year efficacy of lum/iva on lung function and small airway and structural lung disease evaluated by multiple breath nitrogen washout and CT scan. Additionally, we investigated effects of lum/iva on exacerbations, anthropometry, sweat chloride and safety in children with CF in the Netherlands.MethodsChildren with CF aged 6−18 years and homozygous for F508del treated in one of the seven Dutch CF centers for at least 12 months were eligible. Data were extracted from the Dutch CF Registry and electronic patient records. Primary outcome was change in percent predicted FEV1 (ppFEV1) after 12 months.ResultsNationwide, 247 children with CF were eligible for lum/iva. Eight patients discontinued lum/iva due to side effects. In total, 223/247 children (90.3%) were evaluated. Mean (range) age at baseline was 11.0 (6.0−17.1) years. There was no change in FEV1 after 12 months of lum/iva. In a subgroup, markers of small airway function and structural lung disease, such as LCI (n = 28), mean change (SD) −10.0% (15.8), and bronchus‐artery (BA) analysis on CT scan (n = 81), showed significant improvement (p < 0.01). Moreover, BMI (n = 192), exacerbations (n = 219) and sweat chloride measurements (n = 105) improved.ConclusionLum/iva was generally well tolerated in a real‐life, nationwide pediatric cohort. The efficacy of lum/iva was comparable to phase 3 studies in children. LCI and BA analysis as markers of small airway and structural lung disease showed significant improvement which indicates the importance of these parameters to evaluate treatment effects of CF modulators in children.
Genetic Concordance of Staphylococcus aureus From Oropharyngeal and Sputum Cultures in People With Cystic Fibrosis
Authors: Zirbes Christian F. , Feder Andries , Pamatmat Anthony J. , Bartels Alyssa R. , Pitcher Nicholas J. , Rozen Alexis L. , Teresi Mary , Krogh Justin , Regan Margaret , Arnold Erin A. , Hill Jared J. , Reinhardt Lindsey D. , Oberto Carlos L. , Boyken Linda , Reeb Valérie C. , Moustafa Ahmed M. , Planet Paul J. , Fischer Anthony J. 
Published: January 2025

ABSTRACTBackgroundPeople with cystic fibrosis (CF) may not expectorate sputum at young ages or after they receive CFTR modulators. While oropharyngeal swabs are commonly used to test for lower airway pathogens, it is unknown whether Staphylococcus aureus from the oropharynx matches the strain(s) infecting the lungs. Our goal was to determine whether oropharyngeal and sputum isolates of S. aureus are genetically distinct in a cohort of patients with CF.MethodsWe obtained historical S. aureus isolates from patients who intermittently expectorated sputum in 2018, and we prospectively cultured S. aureus from oropharyngeal swabs and sputum from subjects with CF between August 2020 and February 2022. We performed short‐read whole genome sequencing, determined sequence type, and performed phylogenetic analysis using S. aureus core genome single nucleotide polymorphisms (SNPs). We assigned isolates from a patient to the same strain if they had the same sequence type and differed by ≤ 60 SNPs or the isolates were not disturbed by clade breaker analysis.Results36 subjects had S. aureus in ≥ 1 oropharyngeal swab and ≥ 1 sputum in 2018. In the prospective collection, 31 subjects had synchronous oropharyngeal swab and sputum collections. Although polyclonal infections were detected, sputum and oropharyngeal isolates of S. aureus typically matched the same strain within study subjects, both over the span of 2018 (31/36 patients) and when collected simultaneously from 2020 to 2022 (29/31 patients).ConclusionsIn patients with CF who intermittently produce sputum, oropharyngeal swabs identify S. aureus with genetic and phenotypic similarity to those cultured from sputum.
Investigation of the In Vitro Antioxidant, Anticholinesterase, Antiurease, Antityrosinase, and Cytotoxic Properties of a Novel Compound: 4‐Methoxy‐2‐(4‐Methoxyphenyl)Benzo[d][1,3,2]Dioxaborole
Authors: Temel Hamdi , Baydan Emine 
Published: January 2025

ABSTRACTIn this study, the structure of a new boron compound obtained using 3‐methoxy catechol and 4‐methoxy phenyl boronic acid was characterized by 1H, 13C NMR, LC‐MS‐IT‐TOF, UV‐Vis and FTIR spectroscopy. The antioxidant activities of the newly synthesized compound were evaluated by DPPH free radical scavenging, ABTS quation radical scavenging and CUPRAC copper reducing capacity methods. Anticholinesterase activities were determined by acetylcholinesterase and butyrylcholinesterase enzyme inhibitor assays. Antiurease and antithyrosinase enzyme inhibition activities were also examined. Cytotoxic effects were evaluated on healthy cell lines and breast and colon cancer cell lines using MTT method. The results showed that the synthesized compound has high antioxidant activity. Especially the average antioxidant activity values obtained at 10 μg/mL concentration were found to be statistically significantly (p < 0.05) higher than the reference values of α‐TOC and BHT. When the antioxidant activity data (IC50) were compared separately with α‐TOC and BHT reference values, the new compound was found to be more effective. In acetylcholinesterase enzyme inhibition, the average activity values were found to be statistically significantly (p < 0.05) higher than the galantamine reference value. However, no statistically significant difference was observed at BChE (% inhibition) level with galantamine reference value. In terms of urease and tyrosinase enzyme inhibition activities, the urease activity of the synthesized compound was statistically significantly (p < 0.05) lower than the thiurea reference value. Tyrosinase activity was statistically significantly (p < 0.05) lower than kojic acid reference values. The synthesized and characterized compound was found to have no toxic effect on healthy cell lines and did not show any cytotoxic effect on breast cancer (MCF‐7) and colon cancer (HT‐29) cell lines.
An Updated Bio‐Behavioral Profile of the Flinders Sensitive Line Rat: Reviewing the Findings of the Past Decade
Authors: Steyn Stephan F. 
Published: January 2025

ABSTRACTThe Flinders sensitive line (FSL) rat is an accepted rodent model for depression that presents with strong face, construct, and predictive validity, thereby making it suitable to investigate novel antidepressant mechanisms. Despite the translatability of this model, available literature on this model has not been reviewed for more than ten years. The PubMed, ScienceDirect and Web of Science databases were searched for relevant articles between 2013 and 2024, with keywords relating to the Flinders line rat, and all findings relevant to treatment naïve animals, included. Following screening, 77 studies were included and used to create behavioral reference standards and calculate FSL favor ratios for the various behavioral parameters. The GRADE and SYRCLE risk of bias tools were used to scale the quality of these studies. Based on these results, FSL rats display reliable and reproducible depressive‐like behavior in the forced swim test, together with hyperlocomotor activity across various behavioral tests. Despite reports of increased anhedonia, anxiety‐like behavior, and cognitive dysfunction, the reviewed findings indicate that these parameters are comparable between strains. For the various neuro‐ and biological constructs, oxidative stress, energy production, and glutamatergic, noradrenergic and serotonergic neurotransmission received the most support for strain differences. Taken together, the FSL remains a reliable, popular, and translatable rodent model of depression, with strong face and construct validity. As for predictive validity, similar review approaches should be considered to establish whether the mentioned behavioral aspects and neurochemical constructs may be more sensitive (or resistant) to certain antidepressant strategies.
Influence of Iodine Substitutions on the Photophysical Properties of Rhenium(I) Tricarbonyl Complexes With Pyridine Schiff Base (PSB‐IHB)
Authors: Morales‐Guevara Rosaly , Páez‐Hernández Dayán , Ancede‐Gallardo Evys , Carreño Alexander 
Published: January 2025

ABSTRACTThis theoretical investigation aims to evaluate the influence of iodine substitutions on the phenolic moiety of the pyridine Schiff bases harboring an intramolecular hydrogen bond (PSB‐IHB) ancillary ligand within the monocationic. fac‐[Re(CO)3(N,N)(PSB‐IHB)]+ architecture on photophysical properties, particularly emission range. Optimized structures of two Re(I) tricarbonyl complexes (C1 and C2) were analyzed, revealing a distorted octahedral coordination geometry. Geometric parameters were compared with experimental data from analogous complexes. NBO analysis confirmed the presence of intramolecular hydrogen bonds (IHBs) in both singlet and triplet states, providing significant stabilization. Theoretical calculations predicted three distinct absorption bands for all complexes in dichloromethane, indicating substantial electronic delocalization between the pyridinic and phenolic rings via the azomethine group. These findings underscore the crucial role of delocalization and donor–acceptor interactions in stabilizing Re(I) tricarbonyl complexes and their impact on photophysical properties. Emissions calculated for the C1 and C2 complexes were observed within the range of 632–643 nm. The presence of IHBs was found to be essential for modulating photophysical properties, with emissions attributed to ligand‐to‐ligand charge transfer transitions.
Photon Number Coherence in Quantum Dot‐Cavity Systems can be Enhanced by Phonons
Authors: Hagen Paul C. A. , Bozzio Mathieu , Cygorek Moritz , Reiter Doris E. , Axt Vollrath M. 
Published: January 2025

AbstractSemiconductor quantum dots are a versatile source of single photons with tunable properties to be used in quantum‐cryptographic applications. A crucial figure of merit of the emitted photons is photon number coherence (PNC), which impacts the security of many quantum communication protocols. In the process of single‐photon generation, the quantum dot as a solid‐state object is subject to an interaction with phonons, which can therefore indirectly affect the PNC. In this study, the origin of PNC in optically excited quantum dots and its interaction with phonons are elaborated upon. In contrast to the expectation that phonons always deteriorate coherence, PNC can be increased in a quantum dot‐cavity system due to the electron–phonon interaction.
Insight Note. Complications of Magnesium Achromatic X‐Rays in XPS: A Historical and Practical Perspective
Authors: Jafari Samira , Linford Matthew R. , Sherwood Peter M. A. 
Published: January 2025

ABSTRACTThe first, modern X‐ray photoelectron spectroscopy (XPS) spectra were collected with magnesium and aluminum Kα X‐rays, where Mg Kα X‐rays have slightly lower widths (FWHMs) and are therefore more desirable when the achromatic X‐rays are used, although they access a slightly smaller binding energy range and lower escape depth. Although most modern instruments have monochromatized, that is, chromatic with the most intense energy selected, sources and usually do not have attached achromatic (whole X‐ray emission range) sources, there are still instruments with achromatic sources producing useful data as well as a large body of earlier literature and databases providing achromatic source data hence the rationale for this Insight Note. Many newer users of XPS are primarily familiar with chromatic X‐ray sources, including higher energy chromatic sources such as Ag/Cr. The purpose of this short paper is to provide information about the value and complexities that are associated with use of Mg Kα and other achromatic X‐ray sources. In its common, achromatic form, the Mg source produces satellite peaks that should be accounted for in precise work. Dual anode X‐ray sources are made by depositing Mg and Al on copper. In operation, the Al window of this dual anode source is placed close to the sample. Unless it is cooled, a disadvantage of this source is that it can heat the sample. It can also deposit adventitious carbon on a sample. When the Mg source degrades, extraneous signals due to copper may appear in the XPS spectrum.
MnFe2O4@L‐Cysteine as a Drug Delivery System, In Vitro Cytotoxicity Evaluation on Human Breast Cancer Cell (MCF7) and DFT Calculation
Authors: Hasankhani Neda , Hosseini Sharieh , Askarizadeh Elham , Mehravi Bita 
Published: January 2025

AbstractThanks to their high hydrophilic and magnetic properties, MnFe2O4 nanoparticles (NPs) are recognized as favorable drug carriers. In this study, L‐Cysteine‐modified MnFe2O4 nanoparticles (MnFe2O4@L‐Cysteine) were prepared and characterized. Their cytotoxicity against human breast cancer cell lines (MCF7) was also evaluated by MTT assay. To simulate drug delivery systems, the interaction between modified NP and 5‐fluorouracil (5‐FU) was examined as a breast cancer drug. The MTT results showed the applicability of MnFe2O4@L‐Cysteine nanoparticles as a potential cytotoxic agent in breast cancer treatment. Based on the theoretical calculations, the adsorption energy between L‐Cysteine and 5‐FU was −12.029 kJ/mol and their interaction was spontaneous and exothermic at the temperature range of 278.15 to 288.15 K. Also, the drug release thermodynamically is feasible at body temperature. The calculated electronic descriptors indicated that the electrons were transferred from L‐Cysteine to 5‐FU. Overall, MNFe2O4@L‐Cysteine has the potential to deliver 5‐FU.
One‐Pot Synthesis of a Nitrogen‐ and Iodine‐Doped Graphene Composite for Energy Storage Applications
Authors: Dhumal Pratik , Bondarde Mahesh , Lokhande Kshama , Bhakare Madhuri , Some Surajit 
Published: January 2025

AbstractWith the growth of power generation, portable electronic devices are gaining more attention toward energy storage devices, preferably supercapacitors. In this, the surface of graphene was functionalized with conductive polymer by in situ polymerization of pyrrole (PPy) and doping of iodine via hydrothermal method. Doping iodine (potassium triiodide) and nitrogen (polypyrrole) from their respective precursors made GNI composition more suitable for energy storage applications. The synthesized GNI composite showed the maximum specific capacitance of 200 F g−1 at 1.0 Ag−1 with an efficient specific energy of 22.5 Wh kg−1 and specific power of 1800 W kg−1 in a symmetrically arranged two‐electrode Swagelok type cell. The durability of the synthesized composite was analyzed by cyclic stability at current density 10 Ag−1, retaining up to 85% of its initial capacitance after 10,000 repetitive charge‐discharge cycles. The in situ polymerization of pyrrole with the insertion of iodine makes graphene composition more conductive than control graphene, showing a specific capacitance of 111 F g−1 at 1.0 Ag−1. The one‐pot synthetic approach is a simple, easy, and efficient route toward supercapacitor applications. This approach will provide an easy way to introduce N and I to graphene compositions for various applications, including energy storage materials.
Revolutionizing Dual‐Band Modulation and Superior Cycling Stability in GDQDs‐Doped WO3 Electrochromic Films for Advanced Smart Window Applications
Authors: Wu Wenjun , Tian Maofei , Tang Yanbang , Song Chengyu , Zheng Rongzong , Guo Yang , Jia Chunyang 
Published: January 2025

AbstractDual‐band tungsten oxide (WO3) electrochromic films are extensively investigated, yet challenges persist regarding complex fabrication processes and limited cyclic stability. In this paper, a novel approach to prepare graphdiyne quantum dots (GDQDs) doped WO3 films with a hexagonal crystal structure, is presented. Structural characterization reveals that the GDQDs/WO3 possesses a coral‐like, loose structure with high crystallinity due to the synergistic modulation of morphology and crystallinity. Electrochemical tests confirm that this unique structure provides abundant multi‐active sites and efficient electrolyte ion channels, which facilitate the ion insertion/extraction to promote the electrochromic process. The GDQDs/WO3 films exhabit impressive electrochromic performance, with rapid swithing (12.6/8.4 s for bleaching/coloration), high coloring efficiency (104.78 cm2C−1 at 1100 nm), and independent dual‐band transmittance changes (ΔT， with ΔT633 nm = 64.54%, ΔT1100 nm = 83.52% and ΔT1600 nm = 79.80%), and exceptional stability (remained 95.1% modulation range after 20 000 cycles). The unique characteristics of GDQDs lead to the formation of a built‐in electric field via charge transfer, which optimizes and enriches the energy level structure of WO3. This solution not only advances the development of electrochromic technology, but also opens the door for future innovative applications of smart materials.
Photo‐Controllable Förster Resonance Energy Transfer Based on Dynamic Chiral Self‐Assembly of Sequence‐Defined Amphiphilic Alternating Azopeptoids
Authors: Jin Haibao , Liu Fan , Wu Pengchao , Sun Zichao , Sui Pengliang , Cao Yuanyuan , Zhou Yongfeng , Lin Shaoliang 
Published: January 2025

AbstractEndowing biomimetic sequence–controlled polymers with chiral functionality to construct stimuli‐responsive chiral materials offers a promising approach for innovative chiroptical switch, but it remains challenging. Herein, it is reported that the self‐assembly of sequence‐defined chiral amphiphilic alternating azopeptoids to generate photo‐responsive and ultrathin bilayer peptoidosomes with a vesicular thickness of ≈1.50 nm and a diameter of around ≈290 nm. The photoisomerization of azobenzene moiety facilitates a reversible structural transformation from isotropic peptoidosomes to anisotropic 1D helical nanoribbons (≈80 nm width) under the alternating irradiation with UV and visible lights, consequently leading to the chirality expression and transfer from chiral asymmetric center to achiral azobenzene units. As a biomimetic model with deformation‐induced energy transfer, a non‐invasive azobenzene‐based Förster resonance energy transfer system is unprecedentedly constructed via the introduction of a fluorescent donor of pyrene derivatives and sequentially photo‐regulated the donor/acceptor ratio, displaying a reversible gradient fluorescent color variation from blue to yellow (a broad Stokes shift of ≈200 nm) and a high‐efficient energy transfer efficiency of 97.2%. The photo‐controllable photoluminescence phenomenon endows these chiral aggregates with a proof‐of‐concept application on multi‐colored information encryption. This work provides a prospective strategy to fabricate stimuli‐responsive chiral biomimetic materials with a potential on the light‐controllable switches.