bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mortality trends of aortic stenosis in high-income countries from 2000 to 2020
Authors: Hibino Makoto , Pandey Arjun K , Hibino Hiromi , Verma Raj , Aune Dagfinn , Yanagawa Bobby , Takami Yoshiyuki , Bhatt Deepak L , Attizzani Guilherme F , Pelletier Marc P , Verma Subodh 
Published: May 2023

ObjectiveThe purpose of this study is to describe recent mortality trends from aortic stenosis (AS) among eight high-income countries.MethodsWe analysed the WHO mortality database to determine trends in mortality from AS in the UK, Germany, France, Italy, Japan, Australia, the USA and Canada from 2000 to 2020. Crude and age-standardised mortality rates per 100 000 persons were calculated. We calculated age-specific mortality rates in three groups (<64, 65–79 and ≥80 years). Annual percentage change was analysed using joinpoint regression.ResultsDuring the observation period, the crude mortality rates per 100 000 persons increased in all the eight countries (from 3.47 to 5.87 in the UK, from 2.98 to 8.93 in Germany, from 3.84 to 5.52 in France, from 1.97 to 4.33 in Italy, from 1.12 to 5.49 in Japan, from 2.14 to 3.38 in Australia, from 3.58 to 4.22 in the USA and from 2.12 to 5.00 in Canada). In joinpoint regression of age-standardised mortality rates, trend changes towards a decrease were observed in Germany after 2012 (−1.2%, p=0.015), Australia after 2011 (−1.9%, p=0.005) and the USA after 2014 (−3.1%, p<0.001). Age-specific mortality rates in age group ≥80 years had shifts towards decreasing trends in all the eight countries in contrast to other younger age groups.ConclusionsWhile crude mortality rates increased in the eight countries, shifts towards decreasing trends were identified in age-standardised mortality rates in three countries and in the elderly aged ≥80 years in the eight countries. Further multidimensional observation is warranted to clarify the mortality trends.
Bispecific antibodies redirect synthetic agonistic receptor modified T cells against melanoma
Authors: Märkl Florian , Benmebarek Mohamed-Reda , Keyl Julius , Cadilha Bruno L , Geiger Martina , Karches Clara , Obeck Hannah , Schwerdtfeger Melanie , Michaelides Stefanos , Briukhovetska Daria , Stock Sophia , Jobst Jakob , Müller Philipp Jie , Majed Lina , Seifert Matthias , Klüver Anna-Kristina , Lorenzini Theo , Grünmeier Ruth , Thomas Moritz , Gottschlich Adrian , Klaus Richard , Marr Carsten , von Bergwelt-Baildon Michael , Rothenfusser Simon , Levesque Mitchell P , Heppt Markus Vincent , Endres Stefan , Klein Christian , Kobold Sebastian 
Published: May 2023

BackgroundMelanoma is an immune sensitive disease, as demonstrated by the activity of immune check point blockade (ICB), but many patients will either not respond or relapse. More recently, tumor infiltrating lymphocyte (TIL) therapy has shown promising efficacy in melanoma treatment after ICB failure, indicating the potential of cellular therapies. However, TIL treatment comes with manufacturing limitations, product heterogeneity, as well as toxicity problems, due to the transfer of a large number of phenotypically diverse T cells. To overcome said limitations, we propose a controlled adoptive cell therapy approach, where T cells are armed with synthetic agonistic receptors (SAR) that are selectively activated by bispecific antibodies (BiAb) targeting SAR and melanoma-associated antigens.MethodsHuman as well as murine SAR constructs were generated and transduced into primary T cells. The approach was validated in murine, human and patient-derived cancer models expressing the melanoma-associated target antigens tyrosinase-related protein 1 (TYRP1) and melanoma-associated chondroitin sulfate proteoglycan (MCSP) (CSPG4). SAR T cells were functionally characterized by assessing their specific stimulation and proliferation, as well as their tumor-directed cytotoxicity, in vitro and in vivo.ResultsMCSP and TYRP1 expression was conserved in samples of patients with treated as well as untreated melanoma, supporting their use as melanoma-target antigens. The presence of target cells and anti-TYRP1 × anti-SAR or anti-MCSP × anti-SAR BiAb induced conditional antigen-dependent activation, proliferation of SAR T cells and targeted tumor cell lysis in all tested models. In vivo, antitumoral activity and long-term survival was mediated by the co-administration of SAR T cells and BiAb in a syngeneic tumor model and was further validated in several xenograft models, including a patient-derived xenograft model.ConclusionThe SAR T cell-BiAb approach delivers specific and conditional T cell activation as well as targeted tumor cell lysis in melanoma models. Modularity is a key feature for targeting melanoma and is fundamental towards personalized immunotherapies encompassing cancer heterogeneity. Because antigen expression may vary in primary melanoma tissues, we propose that a dual approach targeting two tumor-associated antigens, either simultaneously or sequentially, could avoid issues of antigen heterogeneity and deliver therapeutic benefit to patients.
Combining histological grade, TILs, and the PD-1/PD-L1 pathway to identify immunogenic tumors and de-escalate radiotherapy in early breast cancer: a secondary analysis of a randomized clinical trial
Authors: Stenmark Tullberg Axel , Sjöström Martin , Tran Lena , Niméus Emma , Killander Fredrika , Kovács Anikó , Lundstedt Dan , Holmberg Erik , Karlsson Per 
Published: May 2023

BackgroundThe implementation of immunological biomarkers for radiotherapy (RT) individualization in breast cancer requires consideration of tumor-intrinsic factors. This study aimed to investigate whether the integration of histological grade, tumor-infiltrating lymphocytes (TILs), programmed cell death protein-1 (PD-1), and programmed death ligand-1 (PD-L1) can identify tumors with aggressive characteristics that can be downgraded regarding the need for RT.MethodsThe SweBCG91RT trial included 1178 patients with stage I–IIA breast cancer, randomized to breast-conserving surgery with or without adjuvant RT, and followed for a median time of 15.2 years. Immunohistochemical analyses of TILs, PD-1, and PD-L1 were performed. An activated immune response was defined as stromal TILs ≥10% and PD-1 and/or PD-L1 expression in ≥1% of lymphocytes. Tumors were categorized as high-risk or low-risk using assessments of histological grade and proliferation as measured by gene expression. The risk of ipsilateral breast tumor recurrence (IBTR) and benefit of RT were then analyzed with 10 years follow-up based on the integration of immune activation and tumor-intrinsic risk group.ResultsAmong high-risk tumors, an activated immune infiltrate was associated with a reduced risk of IBTR (HR 0.34, 95% CI 0.16 to 0.73, p=0.006). The incidence of IBTR in this group was 12.1% (5.6–25.0) without RT and 4.4% (1.1–16.3) with RT. In contrast, the incidence of IBTR in the high-risk group without an activated immune infiltrate was 29.6% (21.4–40.2) without RT and 12.8% (6.6–23.9) with RT. Among low-risk tumors, no evidence of a favorable prognostic effect of an activated immune infiltrate was seen (HR 2.0, 95% CI 0.87 to 4.6, p=0.100).ConclusionsIntegrating histological grade and immunological biomarkers can identify tumors with aggressive characteristics but a low risk of IBTR despite a lack of RT boost and systemic therapy. Among high-risk tumors, the risk reduction of IBTR conferred by an activated immune infiltrate is comparable to treatment with RT. These findings may apply to cohorts dominated by estrogen receptor-positive tumors.
Activation of epithelial and inflammatory pathways in adolescent elite athletes exposed to intense exercise and air pollution
Authors: Goossens Janne , Jonckheere Anne-Charlotte , Seys Sven F , Dilissen Ellen , Decaesteker Tatjana , Goossens Camille , Peers Koen , Vanbelle Vincent , Stappers Jeroen , Aertgeerts Sven , De Wilde Barbara , Leus Jasmine , Verelst Sophie , Raes Marc , Dupont Lieven , Bullens Dominique M 
Published: May 2023

RationaleParticipation in high-intensity exercise in early life might act as stressor to the airway barrier.ObjectivesTo investigate the effect of intense exercise and associated exposure to air pollution on the airway barrier in adolescent elite athletes compared with healthy controls and to study exercise-induced bronchoconstriction (EIB) in this population.MethodsEarly-career elite athletes attending ‘Flemish-Elite-Sports-Schools’ (12–18 years) of 4 different sport disciplines (n=90) and control subjects (n=25) were recruited. Presence of EIB was tested by the eucapnic voluntary hyperventilation (EVH) test. Markers at mRNA and protein level; RNA-sequencing; carbon load in airway macrophages were studied on induced sputum samples.Results444 genes were differentially expressed in sputum from athletes compared with controls, which were related to inflammation and epithelial cell damage and sputum samples of athletes contained significantly more carbon loaded airway macrophages compared with controls (24%, 95% CI 20% to 36%, p<0.0004). Athletes had significantly higher substance P (13.3 pg/mL, 95% CI 2.0 to 19.2) and calprotectin (1237 ng/mL, 95% CI 531 to 2490) levels as well as IL-6, IL-8 and TNF-α mRNA levels compared with controls (p<0.05). The incidence of EIB in athletes was 9%. The maximal fall in forced expiratory volume in 1 s (%) after EVH test in athletes was significantly associated with prior PM10and PM2.5exposure.ConclusionEarly-career elite athletes showed increased markers of air pollution exposure, epithelial damage and airway inflammation compared with controls. Acute exposure to increased air pollution PM10levels was linked to increased airway hyper-reactivity.Trial registration numberNCT03587675.
Steps towards generalization of tensionless string theory with contact interactions as Wilson loop of non-Abelian Yang–Mills theory
Authors: Srisangyingcharoen Pongwit 
Published: May 2023

AbstractWe propose a possible modification to the tensionless string model with contact interactions. The proposed model aims to reproduce the expectation value of a non-Abelian Wilson loop in Yang–Mills theory by integrating out string degrees of freedom with a fixed worldsheet boundary. To reproduce path-ordering along the worldsheet boundary, we introduce Lie algebra-valued fields on the string worldsheet, whose dynamics are determined by the topological BF action. Without bulk contributions, we show that the model describes the non-Abelian Wilson loop, neglecting the effects of self-interactions. Finally, we test the reproduction of the Wilson loop with three-point interaction in the case of SU(2).
Multidimensional Analysis of Precursor Information of Rockburst during Loading and Unloading of Deep Diorite
Authors: Liu Jian , Zhou Zonghong 
Published: May 2023

At present, rockburst disasters cannot be predicted accurately, and the prevention and control of deep underground engineering disasters are significantly challenging. To explore the evolution law of precursory information of rockburst instability, the rockburst test of diorite was conducted with high confining pressure and different unloading rates (0.1 MPa/s, 0.3 MPa/s, 0.5 MPa/s, 0.7 MPa/s, and 0.9 MPa/s). Multidimensional analysis is carried out by evaluating deformation features, fast Fourier transform (FFT), energy entropy, singular spectrum entropy, and power spectrum entropy. The results show that Poisson’s ratio is hook-shaped before rockburst, the elastic modulus is in the shape of a step, ringing count and energy surge after a quiet period, three-dimensional law of

0.98

σ

c

~

σ

c

stress location space shows a large red ball distribution along the shear plane,

b

value fluctuates in the low-value range, and low-frequency high amplitude and high-frequency low amplitude fluctuate in a large range after 300 s, with frequent abnormal fluctuations of the energy spectrum entropy, the singular spectrum entropy, and the power spectrum entropy curve. The above research results can be considered the evolution law of rockburst precursor information, which enriches the theoretical method of explosion disaster prediction.
Periostin+ Stromal Cells Guide Lymphovascular Invasion by Cancer Cells
Authors: Null Jamie L. , Kim Dae Joong , McCann James V. , Pramoonjago Patcharin , Fox Jay W. , Zeng Jianhao , Kumar Pankaj , Edatt Lincy , Pecot Chad V. , Dudley Andrew C. 
Published: May 2023

Abstract
Cancer cell dissemination to sentinel lymph nodes is associated with poor patient outcomes, particularly in breast cancer. The process by which cancer cells egress from the primary tumor upon interfacing with the lymphatic vasculature is complex and driven by dynamic interactions between cancer cells and stromal cells, including cancer-associated fibroblasts (CAF). The matricellular protein periostin can distinguish CAF subtypes in breast cancer and is associated with increased desmoplasia and disease recurrence in patients. However, as periostin is secreted, periostin-expressing CAFs are difficult to characterize in situ, limiting our understanding of their specific contribution to cancer progression. Here, we used in vivo genetic labeling and ablation to lineage trace periostin+ cells and characterize their functions during tumor growth and metastasis. Periostin-expressing CAFs were spatially found at periductal and perivascular margins, were enriched at lymphatic vessel peripheries, and were differentially activated by highly metastatic cancer cells versus poorly metastatic counterparts. Surprisingly, genetically depleting periostin+ CAFs slightly accelerated primary tumor growth but impaired intratumoral collagen organization and inhibited lymphatic, but not lung, metastases. Periostin ablation in CAFs impaired their ability to deposit aligned collagen matrices and inhibited cancer cell invasion through collagen and across lymphatic endothelial cell monolayers. Thus, highly metastatic cancer cells mobilize periostin-expressing CAFs in the primary tumor site that promote collagen remodeling and collective cell invasion within lymphatic vessels and ultimately to sentinel lymph nodes.

Significance:
Highly metastatic breast cancer cells activate a population of periostin-expressing CAFs that remodel the extracellular matrix to promote escape of cancer cells into lymphatic vessels and drive colonization of proximal lymph nodes.
Introdução - Dossiê História das Ciências
Authors: Motoyama Shozo 
Published: May 2023

(1º parágrafo do texto)
Nada mais constrangedor ao cientista seja da área natural ou da humana, ouvir comentários desairosos às suas atividades. E estes começam a tornar-se frequentes nos dias de hoje. A balança oscila a favor ou contra, mas parece prender mais para lá do que para cá. Na raíz do desencontro das opiniões encontra-se a perplexidade do homem contemporâneo ante um mundo em rápida transformação. Talvez nunca, em tempo algum, o ritmo da História esteve tão acelerado. As verdades de ontem já não as são de hoje e muito me-nos as de amanhã. O supra-sumo do engenho tecnológico de uma década está irremediavelmente obsoleto na seguinte. Sob um panorama tão móvel, o homem comum, o leigo não especializado, sente-se desorientado e mesmo amedrontado. Mas ele sente, embora não compreenda, a contribuição da Ciência para esse processo. Daí as suas dúvidas e hesitações. Ou então, o seu entusiasmo e certezas.
Aggretriever: A Simple Approach to Aggregate Textual Representations for Robust Dense Passage Retrieval
Authors: Lin Sheng-Chieh , Li Minghan , Lin Jimmy 
Published: May 2023

Abstract
Pre-trained language models have been successful in many knowledge-intensive NLP tasks. However, recent work has shown that models such as BERT are not “structurally ready” to aggregate textual information into a [CLS] vector for dense passage retrieval (DPR). This “lack of readiness” results from the gap between language model pre-training and DPR fine-tuning. Previous solutions call for computationally expensive techniques such as hard negative mining, cross-encoder distillation, and further pre-training to learn a robust DPR model. In this work, we instead propose to fully exploit knowledge in a pre-trained language model for DPR by aggregating the contextualized token embeddings into a dense vector, which we call agg★. By concatenating vectors from the [CLS] token and agg★, our Aggretriever model substantially improves the effectiveness of dense retrieval models on both in-domain and zero-shot evaluations without introducing substantial training overhead. Code is available at https://github.com/castorini/dhr.
How Post-Immunization COVID-19 Context Affected Residents’ Evacuation Behavior during Hurricane Ida
Authors: Polen Amy , Collins Jennifer , Dunn Elizabeth , Murphy Stephen , Jernigan Isabelle , McSweeney Killian , Zhu Yi-Jie 
Published: May 2023

Abstract
Since the onset of the COVID-19 pandemic, decision-making during disasters fundamentally changed to accommodate the combined risks of hurricanes and infectious diseases. Prior research conducted in 2020 by Collins et al. examined how individuals changed their intended evacuation decision-making during the pandemic or their actual evacuation decisions during Hurricanes Laura and Sally. Hurricane Ida provided further data on evacuation decision-making when vaccinations and masks were widely available. A digital survey was disseminated to individuals affected by Hurricane Ida in 2021. Respondents provided information about their actual evacuation choices and perceptions of public shelters and COVID-19 risks. In comparison with the 2020 hurricane season, more individuals have reduced negative perceptions of hurricane shelters. However, individuals were less likely to utilize public shelters than in the 2020 season, with 11.4% more individuals stating they would definitely or probably avoid using shelters in 2021. Fewer individuals identified that COVID-19 was a primary reason they chose to stay home during Hurricane Ida (19.5% as compared with 86.8% during Hurricanes Laura and Sally). Furthermore, respondents with health risks for severe COVID-19 symptoms were no more likely to evacuate than those respondents who had no health risks. Potentially, as the pandemic progressed and vaccine availability and COVID-19 management improved, COVID-19 has had less impact on evacuation decision-making. The results from this work should guide planners in emergency management and public health in future hurricane seasons and future pandemics or other outbreaks to anticipate behavior changes and properly manage infectious disease threats.
Moderating Impact of Dispositional Mindfulness in the Relationship Between Future Expectancies and Psychological Well-Being
Authors: Erguler Hasan , Ferreira Nuno , Adonis Marios , Koushiou Maria 
Published: May 2023

Objectives Mindfulness has been studied under cultivated or dispositional divisions where the latter has strong implications for psychological well-being in meditators and non-meditators alike. In addition, future expectations, or prospections, regarding the occurrence of important events in a person’s future have recently been hypothesized to be the main cause behind symptoms of major depression. There is, however, a lack of empirical research looking at possible links between dispositional mindfulness, as understood in its facet structure, and future expectations as understood via perceived risk of occurrence and vividness of mental imagery when prompted to imagine a given list of positive and negative prospective event item lists. Therefore, this research aimed at examining how dispositional mindfulness may be related to probabilistic risk assessments of positive and negative future events (Stage I); and how mental imagery vividness may be moderated by mindfulness facets (Stage II). Methods Both stages included healthy participants and incorporated the PROCESS macro for moderated regression analysis done with the SPSS software. Stage I included 204 voluntary college students, and Stage II was conducted online with a public sample of 110 adults. Results Although no interaction effect was found in Stage I, nonreactivity to inner experience facet of dispositional mindfulness moderated the relationship between negative imagery vividness and psychological distress in Stage II (F(1,103) = 4.00, R2 change=.018, p <.05). Conclusions This is a novel finding that could inform a future line of research looking into the relationship between prospection and mindfulness, holding a potential for informing research on mindfulness-based interventions.
Effect of dysmorphic plantar arch on venous hemodynamics of the lower limb
Authors: Tsimba Laure , Rastel Didier , Dechandon Emilie , Vincent Patrick , Micholet Céline , Chaigneau Cyril , Avril Stéphane , Aguirre Miquel 
Published: May 2023

Background The role of the plantar venous pump (PVP) on venous return is evident but the effects of the foot morphology have never been characterized properly. Method 52 healthy volunteers—26 with normal plantar arch (control) and 26 with dysmorphic plantar arch (in two subgroups: 13 flat feet, 13 hollow feet)—were included. Using Doppler ultrasound, we measured the diameter and the peak systolic velocity in the large veins of the lower limb after PVP stimulation by manual compression and bodyweight transfer. Result The mean peak systolic velocity of the studied veins varied from 12.2 cm/s to 41.7 cm/s in the control group and from 10.9 cm/s to 39.1 cm/s in the dysmorphic plantar group. The foot arch morphology did not affect significantly the venous blood flows, except in the great saphenous vein during manual compression. Conclusion The plantar morphology did not induce a significant increase of venous blood velocity resulting from PVP stimulation.
The effectiveness of the anti-tumor necrosis factor therapy infliximab in neuro-Behçet’s disease: a systematic review and meta-analysis
Authors: Mohammed Reem Hamdy A , Woldeamanuel Yohannes W 
Published: May 2023

Objective To study the effectiveness of infliximab for the treatment of refractory central neuro-Behçet’s disease. Methods In this systematic review and meta-analysis, the research question was designed using the ‘Population, Intervention, Comparator, and Outcomes’ (PICO) model and the search methodology was developed according to the PRISMA statement. The study was registered on PROSPERO. Web of Science, PubMed, and Cochrane Library databases were searched for articles published in English between January 2000 and January 2020. Data were analysed using Meta-Essentials software, version 10.12. Treatment effect size was determined by a random effects model. Interstudy heterogeneity was explored using I2 statistics. Cumulative meta-analysis was conducted to assess the temporal trend for accumulating evidence. Results Twenty-one studies, comprising 64 patients (mean age, 38 .21 years and mean disease duration, 84.76 months) were included. Effect-size analysis showed that 93.7% of the treated patients in the analysis were responders to infliximab therapy (95% confidence interval 0.88, 0.993). There was no significant inter-study heterogeneity (I2 = 0%). Cumulative analysis showed accumulating evidence favoring increasing effectiveness over the last 20 years. Conclusion Infliximab showed considerable therapeutic effectiveness in the treatment of refractory neuro-Behçet’s disease.