bluuebunny/crossref_metadata_2025_split huggingface dataset:
Surgical aortic valve replacement etiologies, hemodynamics, and outcomes in 1346 patients from the Malaysian Heart Centre
Authors: Roslan Aslannif , Soon Chong Kee , Sin Tey Yee , Aktifanus Ahmad Tantawi Jauhari , Ling Soh Si , Boon Wong Kian , Rusani Beni I. , Hadi Hafidz Abd , Kolanthaivelu Jayakhanthan , Yahaya Shaiful Azmi , Dillon Jeswant , Yunus Alwi M. 
Published: April 2023

Abstract
Background:This study examined the characteristics and outcomes of surgical aortic valve replacement in Malaysia from 2016 to 2021.
Methods: This was a retrospective study of 1346 patients analyzed on the basis of medical records, echocardiograms and surgical reports. The overall sample was both considered as a whole and divided into aortic stenosis (AS)/aortic regurgitation (AR)-predominant and similar-severity subgroups.
Results: The most common diagnosis was severe AS (34.6%),withthe 3 most common etiologies being bicuspid valve degeneration (45.3%), trileaflet valve degeneration (36.3%) and rheumatic valve disease (12.2%). The second most common diagnosis was severe AR (25.5%),with the most common etiologies being root dilatation (21.0%), infective endocarditis (IE) (16.6%) and fused prolapse (12.2%). Rheumatic valve disease was the most common mixed disease. A total of 54.5% had AS-predominant pathology (3most common etiologies: bicuspid valve degeneration valve, degenerative trileaflet valve and rheumatic valve disease), 36.9% had AR-predominant pathology (top etiologies: root dilatation, rheumatic valve disease and IE), and 8.6% had similar severity of AS and AR. Overall, 62.9% of patients had trileaflet valve morphology, 33.3% bicuspid, 0.6% unicuspid and 0.3% quadricuspid. Among cases of severe AS, the majority were high-gradient severe AS (49.9%),followed by normal-flow low-gradient (LG) severe AS (10.0%), paradoxical low-flow (LF)-LG severe AS (6.4%) and classical LF-LG severe AS (6.1%). The overall in-hospital and total 1-year mortality rates were 6.4% and 13.4%, respectively. Pure severe AS had the highest mortality. For AS-predominant pathology, the etiology with the highest mortality was trileaflet valve degeneration; for AR-predominant pathology, it was dissection. The overall survival probability at 5 years was 79.5% in the full sample, 75.7% in the AS-predominant subgroup, 83.3% in the AR-predominant subgroup, and 87.3% in the similar-severity subgroup.
Conclusions: The most common cause of AS is bicuspid valve degeneration,but trileaflet valve degeneration has worse outcomes. Rheumatic valve disease is an important etiology of both AS and AR. Surgical aortic valve replacement has higher mortality in Malaysia than in developed countries.
Trial registration: IJNREC/562/2022
Distinct intrathecal inflammatory signatures following relapse and anti- COVID-19 mRNA vaccination in Multiple Sclerosis. A cross-sectional study.
Authors: Bruno Antonio , Buttari Fabio , Dolcetti Ettore , Azzolini Federica , Borrelli Angela , Lauritano Gianluca , Caprio Veronica , Rizzo Francesca Romana , Gilio Luana , Galifi Giovanni , Furlan Roberto , Finardi Annamaria , Guadalupi Livia , Musella Alessandra , Mandolesi Georgia , Centonze Diego , Bassi Mario Stampanoni 
Published: April 2023

Abstract
Background: The role of off-target inflammatory response to vaccination in exacerbating multiple sclerosis (MS) is a matter of debate.
Methods: In this cross-sectional study, we compared the CSF cytokine profiles associated with MS relapses and anti-COVID-19 mRNA vaccinations in patients with relapsing-remitting MS (RRMS). We also compared central inflammatory responses between RRMS patients and individuals without neuroinflammatory disorders. All patients were recruited in the Neuromed Research Institute, Pozzilli (IS).
Results: We enrolled 97 consecutives unvaccinated RRMS patients with a clinical relapse occurring within 100 days from the diagnostic lumbar puncture (LP), 29 consecutive RRMS in clinical remission, and 24 consecutive controls. The latter groups of patients received anti-COVID-19 mRNA vaccine within 100 days from LP. In the first group, we observed a significant negative correlation between relapse distance and CSF concentrations of IL-2 (Spearman’s rho= -0.305, p = 0.002), IL-6 (Spearman’s rho= -0.291, p= 0.004), and IL-17 (Spearman’s rho= -0.275, p = 0.006). Linear regression confirmed a significant association for IL-2 (beta = -0.265, 95% CI -0.004 - 0, p = 0.016), IL-6 (beta = -0.284, 95% CI -0.005 - -0.001, p = 0.01), and IL-17 (beta = -0.224, 95% CI -0.004 - 0, p = 0.044), considering possible confounders (age, sex, OCB presence, EDSS).
In the second group, distance from vaccination was positively correlated with CSF levels of IL-12 (Spearman’s rho = 0.539, p= 0.003), IL-13 (Spearman’s rho = 0.512, p = 0.005), IL-1ra (Spearman’s rho = 0.481, p = 0.008), MIP-1a (Spearman’s rho = -0.371, p = 0.047). Linear regression confirmed a significant association for IL-12 (beta = 0.536, 95%CI 0.004-0.016, p = 0.004), IL-13 (beta = 0.416, 95%CI 0.001-0.02, p = 0.035), and IL-1ra (beta = 0.506, 95%CI 0.259-2.344, p = 0.016), also considering the effect of other possible confounders (age, sex).
No significant associations between vaccine distance and CSF cytokines levels emerged in the control group.
Conclusion: Our results indicate that COVID-19 vaccination causes in RRMS patients a central inflammatory response significantly different from that associated with disease relapses. The lack of central inflammatory response observed in control patients indicates that MS patients are suscptible to the central inflammatory effects of vaccination.
Exercise-induced secretion of NT-pro BNP in asymptomatic hypertensive patients with type 2 diabetes mellitus – an early sign of subclinical ventricular dysfunction
Authors: Păun Nicolae , Busnatu Ștefan-Sebastian , Jinga Viorel , Iliesiu Adriana Mihaela , Uscoiu Gabriela , Capitanescu Andrei , Nicolae Camelia 
Published: April 2023

Abstract
Background: The association between hypertension (HTN) and type 2 diabetes mellitus (DM) frequently leads to left ventricular diastolic dysfunction (DD).
Methods: We aim to test whether DD can readily be unveiled as early as in the subclinical stage in diabetic hypertensive asymptomatic patients, even before echocardiography can do so. We compared the values of NT-pro BNP (as a marker of increased filling pressures) before and after the treadmill stress test in hypertensive patients with and without diabetes mellitus (DM) and normal subjects. All had normal systolic and diastolic functions at rest and after the stress test, according to the recommendations of the ESC.
Results: The results from our study showed a significant increase inNT-pro BNP after the stress test, but only in hypertensive patients with diabetes.
Conclusion: Compared with echocardiography, measuring the changes inNT-pro BNP after the stress test in hypertensive and diabetic patients with class A heart failure could be a tool for diagnosing DD much earlier in the evolution of the disease. This is an important finding because these patients are difficult to distinguish from those with normal left ventricle function, based only on restingNT-pro BNP or echocardiography. In this way, they can benefit much earlier from specific therapies to mitigate future cardiovascular events.
DNA binding and Antibacterial study of a new highly planar Cu(II) Network
Authors: Li Xuan , Li Juan , Jiang Miao , Song Xue-Qin , Zhang Pei , Zhao Nana , Cheng Hao 
Published: April 2023

Abstract
The DNA binding and the antibacterial activities of metal organic compounds have great significance for the development of anticancer drugs. In this study, a copper coordination network, [Cu2L(H2O)2]n (CuNet), based on H4L where 2,6-pyridine-dicarboxylic acid moieties are spaced by p-benzyloxy, is prepared hydrothermally. Single crystal X-ray analysis demonstrates that the fully deprotonated ligand L4– with high planarity in CuNet adopts a bis-µ2-η1: η1: η2 coordination mode to bind four Cu(II) to render a graphene-like network, which is further propped up to a 3D supramolecular framework through the hydrogen bonds between coordinated water and uncoordinated carboxyl oxygen. Considering its highly planar structural feature and excellent antibacterial properties of Cu(II), the DNA binding and antibacterial performance were explored. The UV-Visible absorption titration and EB-DNA competition determination exhibited that CuNet bound DNA in an intercalation mode with the higher binding constant Kb of 2.42 × 105 M− 1, and the comparable quenching constant Ksv of 1.62 × 104 M− 1 upon compared with the documented DNA linkers. In addition, the antibacterial activity test demonstrates that CuNet exhibits comparable inhibitory effect on Escherichia coli with that of cefradine at the concertation of 0.70 mg/mL. This work has certain significance for the development of metal drugs.
Coping styles and loneliness among patients undergoing hematopoietic stem cell transplantation: the mediating role of self-consistency and congruence
Authors: Gu Jiaxin , Luo Lingping , Hu Yue , Wei Lei , Huang Zhixuan , Gu Dawei , Li Ming 
Published: April 2023

Abstract
Purpose To evaluate the mediating effect of self-consistency and congruence on the relationship between coping styles and loneliness among patients undergoing hematopoietic stem cell transplantation in protective isolation.Methods This study adopted a cross-sectional descriptive survey. A total of 214 hematopoietic stem cell transplantation of patients in protective isolation were recruited at seven hematological centers in China from January 2022 to May 2022.Results Our results showed that self-consistency and congruence mediated the relationship different coping styles (i.e. confrontation, avoidance, and resignation) and loneliness in the patients. Among participants, coping styles of confrontation and avoidance were negatively associated with loneliness.Conclusion When patients are admitted to laminar flow wards, nurses should be concerned about their loneliness sincerely. We recommend paying particular attention to the role of self-consistency and congruence in alleviating the level of loneliness in the patients. Meanwhile, clinical nurses should be oriented towards encouraging the patients to avoid stress temporarily, in addition to taking a positive approach to coping with stress during protective isolation.
Preparation and evaluation of Ir base anode for proton exchange
membrane water electrolysis
Authors: Yazdani Mohammadreza 
Published: April 2023

Abstract
In this project, first, the electrochemical behavior of the catalysts RuO2 and Ir (50)/RuO2 (50) With tests CV, LSV, EIS, and CA was Checked out. From the results of the tests, the catalyst is mixed with an equal ratio of Ir and RuO2 as a suitable catalyst for use in the anode proton exchange membrane water electrolysis is Selected.
Synthesis and characterization of amine functionalized cellulose nanogel for transdermal drug delivery
Authors: Arockiaraj Antoniyar , Sundaramoorthy Subramanian 
Published: April 2023

Abstract
This study presents the synthesis and characterization of an amine-functionalized cellulose nanogel (AFCNG) for potential biomedical applications. AFCNG was synthesized using a combination of acid hydrolysis, TEMPO oxidation, and EDC/NHS-mediated coupling via amide linkage. Biodegradable AFCNG was formulated with a mean size of 74 nm through a regeneration process. Characterization of AFCNG was performed using various techniques such as FTIR spectroscopy, XRD, XPS, Zeta potential, DLS, HRSEM and TGA. The results revealed that AFCNG was amorphous, highly stable in colloidal form, and had higher degradation temperature and water absorption capacity. Biodegradation of AFCNG was also assessed by incubating it with lysozyme for five weeks, which resulted in a degradation level of 83%. Furthermore, hemo-compatibility and cytotoxicity properties of AFCNG were evaluated, and the results showed that it was hemo-compatible and non-toxic to 3T3 cells by cellular morphology assessment with DAPI staining. Curcumin-loaded AFCNG exhibited high cytotoxicity to B16-F10 cells, suggesting its potential as a transdermal drug delivery system for skin cancer treatment. The study concluded that AFCNG possesses the necessary characteristics to serve as a carrier for transdermal drug delivery applications.
Body colour drives optimal insect phenology via thermoregulation
Authors: Fernandez Roberto Novella , Brandl Roland , Pinkert Stefan , Zeuss Dirk , Hof Christian 
Published: April 2023

Abstract

Phenology, the seasonal timing of life events, is an essential component of biodiversity which partly results from species´ life cycle synchronisation to optimal seasonal moments1. The mechanisms involved are, however, complex2–4and understudied which limits our ability to predict biodiversity responses to global change drivers5. Thermoregulation is crucial for shaping diversity patterns, particularly in ectotherms such as insects. Dark-bodied species are able to inhabit colder areas due to their higher absorbance of solar radiation – a pattern known as Thermal Melanism Hypothesis (TMH). Thermal melanism is well supported to drive spatial variation of insect diversity6, but whether it also may influence phenological patterns remains unexplored. Here we show, using a unique dataset of thousands of spatio-phenologically explicit dragonfly and damselfly assemblages, that dragonfly body colour lightness patterns respond to seasonal variation of solar radiation, with darker early- and late-season assemblages and lighter mid-season assemblages. This suggests that colour-based thermoregulation can determine insect phenology in relation to optimal seasonal conditions. We also show that the phenological pattern of dragonfly colour lightness advanced significantly over the last 30 years. Together with static nature of solar radiation, our results suggest that global warming may drive flight periods to suboptimal seasonal conditions. Our findings open a new research avenue for a more mechanistic understanding of phenology and spatio-phenological impacts of climate warming on insects and other ectotherms.
Evaluation of PERSIANN-CCS-CDR, ERA5, and SM2RAIN-ASCAT rainfall products for rainfall and drought assessment in a semi-arid watershed, Morocco
Authors: Najmi Adam , Igmoullan Brahim , Namous Mustapha , El Bouazzaoui Imane , Brahim Yassine Ait , El Khalki El Mahdi , Saidi Mohamed El Mehdi 
Published: April 2023

Abstract

Satellite-based precipitation products, with simultaneously high spatial and temporal resolutions, are mostly needed to assess climate change repercussions. Previous research used datasets neglecting either good temporal or good spatial resolution, PERSIANN-CCSCDR, ERA5, and SM2RAIN-ASCAT are some of the projects aiming to remedy these limitations. This study's goal is to evaluate the accuracy of the PERSIANN-CCS-CDR, ERA5, and SM2RAIN-ASCAT at a monthly scale and their suitability for drought assessment in a Moroccan semiarid watershed. Several statistical indices were computed, the drought SPI was calculated using PERSIANN-CCS-CDR estimates, ERA5 products, and observed records as an input in the SPI formula using Gamma distribution to simulate drought from 1983 to 2017. The preliminary comparison and evaluation results of PERSIANN-CCS-CDR estimates and ERA5 datasets showed good CC on a basin scale for monthly precipitation, with a slight overestimation of the observed precipitation shown by the PBIAS. The NSE scored 0.41 for PERSIANN-CCS-CDR and 0.72 for ERA5. The results for SM2RAIN-ASCAT showed an overestimation of the observed precipitation data. At the basin scale, the SPI3 correlation coefficients between the PERSIANN-CCS-CDR monthly estimates and observed gauge rainfall data were greater than 0.67, and the RMSE was closer to 0, outperforming ERA5 in the SPI3 evaluation.
Exploring Chronic Pain and Pain Management Perspectives: Qualitative Pilot Analysis of Web-Based Health Community Posts
Authors: Harter Claire , Ness Marina , Goldin Aleah , Lee Christine , Merenda Christine , Riberdy Anne , Saha Anindita , Araojo Richardae , Tarver Michelle 
Published: April 2023

Background
Patient perspectives are central to the US Food and Drug Administration’s benefit-risk decision-making process in the evaluation of medical products. Traditional channels of communication may not be feasible for all patients and consumers. Social media websites have increasingly been recognized by researchers as a means to gain insights into patients’ views about treatment and diagnostic options, the health care system, and their experiences living with their conditions. Consideration of multiple patient perspective data sources offers the Food and Drug Administration the opportunity to capture diverse patient voices and experiences with chronic pain.

Objective
This pilot study explores posts from a web-based patient platform to gain insights into the key challenges and barriers to treatment faced by patients with chronic pain and their caregivers.

Methods
This research compiles and analyzes unstructured patient data to draw out the key themes. To extract relevant posts for this study, predefined keywords were identified. Harvested posts were published between January 1, 2017, and October 22, 2019, and had to include #ChronicPain and at least one other relevant disease tag, a relevant chronic pain management tag, or a chronic pain management tag for a treatment or activity specific to chronic pain.

Results
The most common topics discussed among persons living with chronic pain were related to disease burden, the need for support, advocacy, and proper diagnosis. Patients’ discussions focused on the negative impact chronic pain had on their emotions, playing sports, or exercising, work and school, sleep, social life, and other activities of daily life. The 2 most frequently discussed treatments were opioids or narcotics and devices such as transcutaneous electrical nerve stimulation machines and spinal cord stimulators.

Conclusions
Social listening data may provide valuable insights into patients’ and caregivers’ perspectives, preferences, and unmet needs, especially when conditions may be highly stigmatized.
Computación sin servidor
Authors: Salazar Argonza Javier 
Published: April 2023

La Computación sin Servidor o Serverless Computing es una tendencia tecnológica que surgió en años recientes y forma parte de una nueva generación de productos y servicios ofertados por los centros de datos (proveedores de servicios en la nube), que busca facilitar a las empresas e instituciones, el cumplimiento de sus objetivos de negocio. La computación sin servidor, a pesar de su nombre, no implica la eliminación del uso de servidores de aplicaciones, más bien es un nuevo tipo de servicio a través de Internet, que facilita a las empresas e instituciones crear y ejecutar sus aplicaciones y/o servicios de software, sin tener que preocuparse por los diferentes aspectos técnicos asociados a la infraestructura física en la que éstos deben residir. En el presente artículo, se explica en qué consiste la computación sin servidor; se indican algunos casos en donde su uso es recomendado; se comentan las principales ventajas y desafíos para migrar a esta tecnología, y se explican las diferencias entre las principales plataformas tecnológicas de computación sin servidor, disponibles en el mercado. Finalmente, se introduce al lector en el tema de la selección de los marcos de desarrollo de código abierto, sin servidor multiplataforma, Serverless Frameworks.
desenvolvimento profissional de uma treinadora brasileira de tênis no alto rendimento
Authors: Marchetti Moura Willian Alexander , Milan Fabrício João , Corrêa Cortela Caio , Ciampolini Vitor , Milistetd Michel 
Published: April 2023

O objetivo do estudo foi investigar as experiências que contribuíram para a ascensão de uma treinadora brasileira de tênis no alto rendimento. Para isso, esta pesquisa descritiva de abordagem qualitativa foi orientada por meio de um estudo de caso único. No momento do estudo, Fernanda tinha 30 anos de idade e 12 anos de experiência como treinadora em nível nacional e internacional. Enquanto estratégias para a coleta dos dados, foram utilizados nesta ordem: a Rappaport timeline e a entrevista semiestruturada. A análise desses dados foi conduzida por meio das orientações da análise temática reflexiva. Os resultados versam pelos seguintes temas: (a) Influência, Conexão e Inspiração: Personagens Fundamentais; (b) Perfil Promissor e Acolhimento no Contexto; e (c) Desenvolvimento Enquanto Treinadora: Os Constantes Aprendizados e Questionamentos no Percurso. De modo geral, Fernanda teve uma trajetória orientada por relações de influência com personagens de seu contexto. Os momentos fora de sua zona de conforto contribuíram para a definição de estratégias que visem suprir as necessidades e avançar perante as barreiras identificadas.
Diseño e implementación de un sistema de monitoreo de parámetros de calidad de agua en cultivo de tilapia en una granja piscícola del departamento del Cauca
Authors: Plazas Pemberthy Luz Adriana , Paz Ruiz Nelson Emilio 
Published: April 2023

El monitoreo de calidad de agua para el cultivo de peces es fundamental para incrementar la productividad y competitividad de los piscicultores. La cadena piscícola Caucana se encuentra en un estado de transición entre enfoque de subsistencia hacia enfoque de cadena productiva (Ruano, Silva and Rivera, 2015) y por lo tanto requiere de la introducción con desarrollos tecnológicos que le ayuden a reducir los factores de vulnerabilidad. Partiendo de este enfoque, se diseñó e implementó un prototipo electrónico de monitoreo de parámetros de calidad de agua, como temperatura, pH, amoniaco y oxígeno disuelto del agua, con el fin de identificar los valores óptimos que garanticen la reducción de las tazas de mortalidad en los cultivos de peces. Las pruebas de campo se realizaron en la granja piscícola “Mamá Lombriz”, ubicada en el municipio de Popayán, en el departamento del Cauca (Colombia). El hardware del prototipo se compone de una sección de acondicionamiento electrónico y un microcontrolador, en el que se realiza el proceso de muestreo, acondicionamiento, adquisición y procesamiento de datos para su despliegue y almacenamiento en computador. La información es enviada por conexión USB a un software con interfaz gráfica para que el usuario visualice las variables y pueda tomar acciones correctivas de acuerdo a cada situación. Con este prototipo se espera contribuir al mejoramiento de las actividades productivas de la cadena piscícola incrementando la competitividad (Joaquí-Daza, 2011) de los agentes productores y reduciendo los porcentajes de mortalidad en los peces cultivados
The Behavioral Effects of Social Distance and Residual Claim Distribution on Budget Reporting in Hierarchical Organizations
Authors: Kuang Xi , Majerczyk Michael , Yang Di 
Published: April 2023

ABSTRACT
We experimentally investigate how subordinates’ budget reporting in hierarchical organizations is influenced by social distance between subordinates and their direct manager. Although prior research promotes reducing this social distance to improve cooperation and efficiency, we contend that reduced social distance can differentially influence budget reporting, conditional on the manager’s stake in the residual claim. As predicted, we find through two studies that the effect of reduced social distance changes from increasing subordinates’ honesty to decreasing subordinates’ honesty as the manager’s stake in the residual claim decreases. We also find that subordinates’ concern for the manager’s economic well-being and concern about the manager’s impression of their reporting behavior mediate these results. The implications of our findings for management accounting theory and practice are discussed.
Data Availability: Please contact the authors.
JEL Classifications: C91; D91; M41.