bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of satisfaction with antiretroviral drugs and the need for long-acting injectable medicines among people living with HIV in Japan and its correlative determinants: a prospective multicenter cross-sectional observational study
Authors: Ishihara Masashi , Higasa Shinichi , Tsukiji Mariko , Kunimoto Yusuke , Nobori Kazuko , Kimura Takeshi , Onishi Kenta , Yamamoto Yuki , Haruta Kyohei , Kashiwabara Yohei , Fujii Kenji , Shimabukuro Shota , Watanabe Daichi , Tsurumi Hisashi , Suzuki Akio 
Published: April 2023

Abstract

Background:Long-acting injectable formulations for HIV infection have been approved and are now available in Japan. Although not currently recommended as first-line drugs in Japanese or overseas guidelines, use of such formulations may increase, in accordance with patient conditions and preference. We determine the level of satisfaction with current anti-HIV drugs and analyzed the preferences of patients who favor long-acting injectable drugs based on their satisfaction level with the present anti-HIV drugs.Methods:People living with HIV (PLWH) who had received antiretroviral therapy (ART) for at least one month and consented to the study between 1 April and 31 December 2021 were included in a survey conducted using a self-administered questionnaire. The content of the survey included satisfaction with seven items (tablet size, ease and feeling when taking the medicine, color, taste, portability, daily oral therapy, and co-payment) related to the anti-HIV drugs they were taking and their need for future drugs (dosage form, frequency of dosing, long-acting injectable, etc.). In addition, factors related to the need for long-acting injectable medications were analyzed with regard to the relationship with satisfaction with anti-HIV drugs.Results:Overall, 667 patients available for analysis were included in this study. Satisfaction with anti-HIV drugs was highest with regard to "co-payment" and lowest with "daily oral therapy". Regarding the need for long-acting injectable medications, logistic regression analysis indicated that tablet size and daily oral therapy were significant predictors of patient preference for a once-every-eight-weeks intramuscular formulation in terms of their requirement for long-acting injectable medications (tablet size, OR=2.14, 95%CI 1.030-4.430, p=0.042; and daily oral therapy, OR=1.75, 95%CI 1.010-3.030, p=0.044).Conclusions:Patients currently receiving anti-HIV drugs who express dissatisfaction with tablet size and daily oral therapy may prefer a long-acting injectable formulation, taking into consideration patient age, employment status, ART history, frequency of daily dosage and concomitant medications other than ART.
AMFC: A New Approach Efficient Junctions Detect via Maximum Flow Approach
Authors: ÖZTEMİZ Furkan 
Published: April 2023

Abstract
In this study, max flow analysis processes are carried out with a graph theory-based approach that can be used in optimizing the traffic load in transportation networks. The data used in the study consists of 2 years of vehicle number data consisting of 438 million vehicle passes of a real city. Bottleneck points affecting traffic flow, maximum flow values, and effectiveness values of traffic generating and attracting locations were determined in the uniquely created transportation network. The Ford-Fulkerson algorithm was used to determine the maximum flow and bottleneck road connections in the designed transportation network. According to the maximum traffic flow to the junction point, the most effective junction points were determined by the PageRank algorithm. In addition, a unique algorithm is presented in the study that determines the effective intersection points that transfer vehicle traffic at maximum capacity to all junction points according to the maximum demand capacity data.
Climate change impacts and responses index: risks, opportunities and policy implications
Authors: Xie Yi , Li Huimin , Liu Jingshu , Han Lefei , Zhang Xiaoxi , Zhou Xiaonong , Guo Xiaokui , Xiu Leshan , Yin Hao , Yin Kun 
Published: April 2023

Abstract
Identifying climate change risks, vulnerability of exposed population and responses to climate change are critical to develop effective strategies to mitigate climate hazards. In this study, we have developed a climate change impacts and responses (CCIR) index that incorporates comprehensive information on climate risks, health burdens and actions that are taken in response to climate risks and damage. According to our knowledge, the CCIR index is the first of its kind that explores both climate impacts and mitigation actions. The CCIR index was positively correlated with national GDP per capita because wealthier countries can allocate more resources to mitigating climate impacts. Countries with better climate education tended to lower their carbon footprint. Furthermore, countries with higher risks of emerging infectious diseases that were more likely to consume more renewable energy. By identifying climate risks and opportunities, the CCIR index can help policymakers design, refine, and implement adaptation policies and actions to respond to the impacts of climate change.
Combinatorial slot-die coating for high-throughput compositional screening of perovskite solar cells
Authors: Li Jinzhao , Shargaieva Oleksandra , Maticiuc Natalia , Zizak Ivo , List-Kratochvil Emil , Unger Eva 
Published: April 2023

Abstract

We here present a generic methodology enabling the accelerated optimization of the composition and processes conditions for functional solution-processable materials compatible with later transfer of optimized conditions to scaled device manufacturing. In combinatorial slot-die coating, two or more precursor inks are fed with different rates into the slot-die enabling fast screening of the precursor solution composition on coating property in one experimental run, which can either be implemented as consecutive coatings with different compositions or as a continuous compositional gradient. As a first example, we here present combinatorially slot-die coated halide perovskite thin-films ranging from the precursor compositions of pure formamidinium lead iodide, FAPbI3, to methylammonium lead bromide, MAPbBr3. In this series, both the optical and morphological properties of the deposited thin-films change dramatically. An increasing faction of MAPbBr3 resulted in larger optical bandgaps. At very high MAPbBr3 ratios, differences in the thin-film crystallization kinetics due to the simultaneous change of the precursor solution solvent resulted in thin-films with low quality morphology. The spatial compositional homogeneity of the coated thin-films was characterized by grazing incidence wide angle X-ray scattering mapping. We fabricated inverted perovskite solar cells in the full compositional range and found a performance maximum for FAPbI3-richer devices with a MAPbBr3-content of 20 mol%. The performance maximum can be rationalized with the improved thermodynamic stability of the halide perovskite crystal structure due to a more ideal tolerance factor upon incorporation of the smaller methylammonium cation and bromide anion into the crystal structure. At high MAPbBr3-content, the device performance drops due to two effects: light-induced phase-segregation and a dramatically decreased thin-film morphology exhibiting pinholes. The example highlights the critical balance of precursor solution composition and processing conditions as the crystallization kinetics critically affect the resulting thin-film quality and morphology. This generic methodology can be further optimized and exploited to identify optimal precursor solution compositions and process conditions to achieve high-quality thin films with a target composition and sample morphology with high experimental throughput.
New Substances Notification Regulations (Organisms) (NSNR(O)): Microbial Characterization and Key Elements for Importation to Canada
Authors: Singh Om 
Published: April 2023

Any new substance imported into or manufactured in Canada is subject to New Substances Notification (NSN) under the Canadian Environmental Protection Act (CEPA) of 1999. The manufacturer or importer needs to comply with the New Substances Notification Regulations (NSNR) before the substance can be sold in the Canadian marketplace. While the section of the NSNR for biotechnology products has been in place since September 1, 1997, few microorganisms have been reviewed. The regulations also apply to various "higher" organisms such as fish, livestock, and insects (depending on the type of use). Applicants are required to provide a variety of technical information about their products in their NSN submissions to Environment Canada, the regulatory agency responsible for approving new substances in Canada. However, improper interpretation of the regulations leads to challenges for manufacturers/importers in the application process. There are ways to reduce an application's major deficiencies and/or potential for rejection. This paper aims to emphasize best practice tips for bringing new microorganisms to the Canadian marketplace that can benefit biotechnology product manufacturers at the forefront.
https://doi.org/10.21423/jrs-v08singh
A Special Issue of the Journal of Regulatory Science on Genetically Modified Organisms
Authors: Molins Ricardo 
Published: April 2023

The Journal of Regulatory Science, now in the first year in continuous publication mode, is proud to publish its first Special Issue, which examines some proposals from industry to facilitate the structuring of a more widely accepted, science based, standardized future international regulatory framework for approval of genetically modified organisms.
doi: 10.21423/jrs-v09i1molins
Analytical Uncertainty in Animal Feed Laboratories: A Current Evaluation of AAFCO Proficiency Testing Data for Select Analytes
Authors: Herrman Timothy , Lee Kyung-min , Hsieh Yi-Cheng , Williams Sara 
Published: April 2023

The animal feed regulatory community utilizes analytical variations (AVs) that account for the normal variability that occurs within and between laboratories. The AV was created using the Association of American Feed Control Officials (AAFCO) proficiency testing (PT) program results and represent the coefficient of variation times 2 (2 CV). This study was performed to assess the accuracy of the published AVs within the association’s Official Publication (OP) using AAFCO PT data from 2014 to 2020. This study also reevaluated the current AV values by applying the concept of the measurement uncertainties including the expanded uncertainty (U), Horwitz value, and 2 CV for the assessment of the label guarantees. Although greater variations were observed at lower concentrations, the majority of data points from the PT rounds showed an acceptable reproducibility for the select analytical methods except for cobalt, fat, fiber, moisture, and selenium where 2 CV was higher than the current AAFCO AV. Regression models were developed based on the 95% tolerance interval of expanded uncertainty and 2 CV and were validated using the 2019-2020 AAFCO PT data. The validation data fell within the expanded uncertainty and 2 CV model bounds indicating the new models were fit-for-purpose and accurately characterized current AAFCO PT data. The study results imply the AAFCO AV and its issues need to be better understood to improve an accuracy and traceability of the laboratory’s measurement and thus regulatory decisions to help animal feed producers and processors lower economic losses.
Kojic Acid and Kojic Acid Ester: Review on Nanotechnology-based
Approach for Enhancing the Delivery Efficacy
Authors: Lokman Hakim Nur Yasmin Diana , Joginder Singh Hardeep Kaur , Kang Nien How , Siau Hui Mah , Zee Wei Lai 
Published: April 2023

Abstract:
Kojic acid (KA), a fungal secondary metabolite, is commonly used in the cosmetic industry
as a skin-whitening agent because of its ability to inhibit tyrosinase, the enzyme involved in melanin
production. However, KA has shown poor depigmenting effects and becomes unstable after prolonged
storage. Its use in cosmetics products has also been restricted due to its hydrophilic nature. To overcome
these limitations, the structure of KA can be altered to form KA derivatives, such as KA ester
(KAE), with improved chemical and biological properties. For instance, multiple studies have shown
that KAE is more effective at inhibiting tyrosinase, is less toxic and more stable than KA, thus making
it more beneficial. Aside from structural modification, nanotechnology applications such as
nanoemulsion, and others have shown the ability to strengthen the efficacy of both KA and KAE by
increasing skin permeability and delivering the drug more precisely to the targeted site with better
controlled release rate. Therefore, the aim of this review article is to discuss the importance of modifying
KA’s chemical structure as well as the role of nanoemulsion, solid lipid nanoparticles (SLN),
nanostructured lipid carrier (NLC), liposomes and ethosomes in improving topical delivery of KA and
KAE for cosmetic and pharmaceutical applications.
Regência escolar: estratégias didáticas usadas pelos residentes no contexto remoto
Authors: Franco Carlos Alberto Aquino , Marques Valéria Risuenho 
Published: April 2023

Este artigo apresenta resultados parciais do projeto de pesquisa intitulado “Programa Residência Pedagógica (PRP): aspectos do percurso formativo de residentes". Tal projeto tem como objetivo evidenciar em que aspectos o PRP contribui para a formação inicial dos licenciandos residentes do curso de Licenciatura Integrada em Ciências, Matemática e Linguagens da Universidade Federal do Pará. Para este texto, buscamos identificar estratégias didáticas utilizadas por residentes nas regências ocorridas no ensino remoto, tomando como referência os conteúdos conceituais e procedimentais de Zabala (1998). Metodologicamente, o estudo é de caráter descritivo-interpretativo, com abordagem qualitativa, que se apoia, como técnica de constituição de dados, na análise documental, tomando como referência os registros realizados em diário de bordo durante a observação de aulas Desse estudo é possível afirmar que a regência escolar é um alicerce fundamental no processo educativo do licenciando por unir a teoria com a prática, de forma a contribuir para a formação inicial como educador. Além disso, foi possível identificar que os residentes usaram os recursos que dominavam para dinamizar aulas online, bem como contemplaram, nos slides usados, conteúdos conceituais e procedimentais dos objetos de conhecimento trabalhados.
O uso de jogos didáticos-pedagógicos no ensino de ciências como método de ensino e aprendizagem na EMEF Brigadeiro Haroldo Coimbra Veloso em Itaituba-PA
Authors: Silva Patrícia Lima da , Almeida Vilma Ribeiro de 
Published: April 2023

O Ensino de Ciências envolve uma série de termos científicos que muitas vezes leva a uma dificuldade durante o processo de assimilação e apreensão dos conteúdos pelo aluno, sendo necessário que o professor busque formas de tornar as aulas mais atrativas e compreensíveis, utilizando de diversas ferramentas pedagógicas, dentre elas estão os jogos didáticos-pedagógicos. Isso porque, os jogos didáticos conseguem atingir diversas finalidades, ligados às funções cognitivas, aos processos relacionados ao desenvolvimento da inteligência e da personalidade, que estão na base da construção do conhecimento. O presente artigo teve como objetivo desenvolver e aplicar um recurso didático que auxilie alunos com dificuldade no entendimento de alguns conteúdos da disciplina de ciências. Os caminhos percorridos pela pesquisa foram de uma pesquisa básica de abordagem qualitativa, quanto aos procedimentos técnicos utilizou-se a pesquisa de campo com levantamento bibliográfico. Considera-se que esta pesquisa contribuiu para a compreensão e importância dos jogos para o processo de ensino e aprendizagem do aluno e sobretudo no ensino da disciplina de ciências.
Represión inquisitorial después de la guerra de las Alpujarras
Authors: Pérez de Colosía Rodríguez Mª Isabel 
Published: April 2023

En la guerra de las Alpujarras eclosionaron una serie de tensiones que, durante todo el siglo XVI, existieron entre los cristianos viejos y los nuevamente convertidos. Vencidos los moriscos por los ejércitos reales, se llevaron a cabo una serie de represalias contra ellos. Por una parte fueron esclavizados y expulsados de los territorios que les vieron nacer, por otra, el Santo Oficio de la Inquisición no quiso dejar sin castigo a aquellos que se habían separado de la ortodoxia y volvieron a realizar los ritos islámicos. En consecuencia, se celebróen Granada, el año 1571, un auto público de fe donde el 89 % de los sentenciados lo fueron por practicar la religión musulmana y haber participado en la guerra de las Alpujarras. Entre los procesados encontramos varios familiares de Hernando de Córdoba y Válor, quien tomó el nombre de Aben Humeya durante la rebelión morisca.
La estela decorada y la espada de lengua de carpa del Bronce Final de Almargen-Málaga
Authors: Villaseca Díaz Fernando 
Published: April 2023

Con el presente artículo damos a conocer dos nuevas piezas; una espada de lengua de carpa y una estela de guerrero, ambas pertenecientes al Bronce Final. Pero quizás lo más significativo sea la ampliación territorial de este tipo de hallazgos, y más aún cuando esto sucede en zonas, donde este horizonte cultural está vagamente conocido, abriendo con ello nuevas perpectivas de estudio.
Humanismo, escritura e imprenta
Authors: Arroyal Espigares Pedro , Martín Palma María Teresa 
Published: April 2023

Subrayan los autores la importancia de los medios y modos de comunicación para explicar la historia humana, intentando demostrar cómo los grandes cambios sociales económicos o culturales han estado siempre acompañados, cuando no precedidos, por nuevas formas de comunicación.
Estado y municipio malagueño en el siglo XVII: aspectos militares
Authors: Villas Tinoco Siro 
Published: April 2023

Como un aspecto sustancial en el contexto de la lucha por el control del poder político y social que caracterizó el nacimiento y la consolidación del Estado Moderno, el presente articulo aborda las tensas relaciones entre la Monarquía y el Municipio Malagueño durante el siglo XVI, analizando, específicamente, los aspectos relativos a la defensa de la ciudad, del Reino y de la expansión norteafricana, con el correlato de solicitudes y aportaciones humanas y materiales que conformaron la contribución militar malacitana al Estado Absoluto.
La sociabilidad popular en la Andalucía del siglo XIX: elementos de permanencia y de tradición
Authors: Morales Muñoz Manuel 
Published: April 2023

Como observó Maurice Agulhon en sus estudios sobre la Francia meridional, la ciudad del XIX ofrece a sus habitantes múltiples ocasiones, espacios y formas de sociabilidad. El análisis de algunos de estos elementos, en particular la calle, el café, la taberna y el taller, es lo que aborda el presente trabajo, al objeto de determinar si el modelo teórico, conceptual y metodológico propuesto para Francia resulta válido para una sociedad como la andaluza, caracterizada frecuentemente como una sociedad poco estructurada y con débiles sistemas de relaciones.
La organización municipal en la repoblación de Carlos III
Authors: Villas Tinoco Siro 
Published: April 2023

El proyecto colonizador de Carlos III en Sierra Morena y Andalucía se plasmó en una Real Cédula de 1767, que contenía la Instrucción y Fuero de Población por el que, necesariamente, se habrían de regir los futuros asentamientos del camino de Andalucía. En este artículo se analiza el reglamento para la constitución de las corporaciones locales, situándolo en el contexto económico, político, social e ideológico de la España Ilustrada.
La pesca en Andalucía: una aproximación
Authors: López Cano Damián , Santiago Ruiz Francisco J. 
Published: April 2023

El sector pesquero en Andalucía se encuentra inmerso en una crisis que se puede trasladar con poca diferencia al resto de las áreas pesqueras españolas y comunitarias; provocada por deficiencias estructurales y un sobredimensionamiento de la flota en relación, principalmente a la capacidad de los caladeros. En su relación con el resto de los sectores productivos andaluces, a pesar de la escasa significación económica que posee tanto en números absolutos como porcentuales, es de gran importancia para amplias zonas costeras andaluzas, de aquí el interés que nos ha llevado a la realización de este trabajo.
Comparación de distintos estimadores del riesgo de erosión (factor A de la U.S.L.E. y ecuación de regresión múltiple). Cuenca del río Alcaucín
Authors: Perles Roselló María Jesús 
Published: April 2023

El articulo recoge los resultados de una valoración comparativa de la capacidad de dos estimadores del riesgo de erosión para predecir el estado de erosión (factor A de la U.S.L.E. y ecuación de regresión múltiple elaborada por nosotros). Se adjunta una descripción del proceso de elaboración de estos estimadores, así como la cartografía obtenida de su aplicación para la cuenca del río Alcaucín.
La quema de iglesias en la tierra de Vélez-Málaga durante la rebelión morisca de 1568
Authors: Suberbiola Martínez Jesús 
Published: April 2023

Los historiadores de la rehelión morisca de 1568, al centrarse en los acontecimientos de las Alpujarras, narraron con menor detalle los sucesos del obispado de Málaga. Sin embargo, aquí se quemaron veinte iglesias. Este artículo pretende esclarecer cuales eran las relaciones entre el clero y los moriscos para llegar a esos extremos.
Descubriendo la ciudad (II). La arquitectura malagueña según los viajeros extranjeros del siglo XIX: la catedral
Authors: García Gómez Francisco 
Published: April 2023

En este segundo trabajo sobre la visión del arte malagueño ofrecida por los viajeros del XIX, nos centramos en las diversas impresiones que les producía la Catedral, un edificio que no siempre ha sido valorado con justicia pero que algunos de esos extranjeros acertaron a comprender. También se muestran sus comentarios acerca de las irregulares obras de arte conservadas entre sus muros.
Iconografía dieciochesco en Málaga. Interpretaciones escultóricas del tema de la Divina Pastora
Authors: Sánchez López Juan Antonio 
Published: April 2023

La iconografía de la Virgen como Divina Pastora de las almas constituye una de las escasas novedades temáticas en e! arte español del siglo XVIII. Su extraordinario éxito popular responde a la predilección suscitada por la vida bucólica en la sociedad de la época, merced a su introducción en la ópera y el teatro. La perspectiva histórica y la proyección artística de dicho asunto en la escultura barroca malacitana completan el objeto de análisis del presente trabajo.
Una estrategia para el desarrollo rural integrado, los programas LEADER. Su desarrollo en la provincia de Málaga
Authors: Larrubia Vargas Remedios , Navarro Rodríguez Susana R. 
Published: April 2023

Dentro de la iniciativa LEADER aprobada por la U.E. con la finalidad de conseguir el desarrollo de zonas rurales deprimidas mediante la potenciación de sus recursos autóctonos tanto humanos como económicos, en la provincia de Málaga fueron aprobados dos proyectos, los de la Serranía de Ronda y la Axarquía, cuyo desarrollo y logros exponemos en este trabajo.
Aportaciones al estudio del arquitecto Felipe de Unzurrúnzaga
Authors: Camacho Martínez Rosario 
Published: April 2023

El siglo XVIII fue una época de despegue de la economía malagueña y la arquitectura vivió su etapa de esplendor, que arranca desde la última década del siglo XVII con la promoción artística de los condes de Buenavista. A ellos se vincula el arquitecto vasco Felipe de Unzurrunzaga, que vivió en Málaga durante más de cuarenta años, en los que realizó notables obras, aportando un sello personal y de calidad estética a esta arquitectura, que se analiza en el presente artículo.