bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of Genome Wide Associated Variants rs2651899 (PRDM16), rs11172113 (LRP1), and rs10166942 (TRPM8) of Migraine in the Indian Episodic Migraineurs
Authors: Manickam Agaath Hedina , Ramasamy Sivasamy 
Published: August 2023

Background:
The involvement of genes in migraine pain is identified by several studies. Many genome-wide association studies (GWAS) revealed the presence of particular variants in different migraine populations worldwide.

Objective:
This study aims in analyzing the presence of 3 GWAS variants (rs2651899 [PRDM16], rs11172113 [LRP1], and rs10166942 Transient Receptor Potential Cation Channel Subfamily M Member 8 [TRPM8]) in the Indian episodic migraineurs.

Methodology:
Enrolled 200 age- and gender-matched patients and control volunteers; collected blood samples to isolate DNA to check the presence of chosen variants in them. The results obtained were statistically analyzed using SPSS version 26.0.

Results:
The rs10166942 (TRPM8) variant is observed in 1.5% of control, 15.88% of migraine with aura, and 5.37% of migraine without aura subjects with the highly significant P < 0.0008. The other two variants are absent in the chosen sample group.

Conclusion:
We reported the presence of rs10166942 in the Indian episodic migraineurs and we recommend pathway analysis for confirming its association with the migraine pain progression.
Multidetector Computed Tomographic Evaluation of Hydrocephalus
Authors: Dhande Rajasbala Pradeep , Pandey Shivesh , Mishra Gaurav Vedprakash 
Published: August 2023

Introduction:
Hydrocephalus is characterized by imbalance of cerebrospinal fluid formation and absorption. It is manifested as a dilatation of the ventricular system. Computed tomography (CT) is useful in determining the ventricular size and shape as well as the amount of the cerebral cortex present in the evaluation of suspected hydrocephalus.

Aim and Objectives:
Detection of hydrocephalus and determining the cause of hydrocephalus. Differentiating communicating from noncommunicating (obstructive) hydrocephalus. to assess the severity of the hydrocephalus and seek for any consequences.

Materials and Methods:
This prospective study included 50 patients referred to the Acharya Vinoba Bhave Rural Hospital, Sawangi (Meghe), Wardha, for 1 year. Patients clinically diagnosed with hydrocephalus were included in the study. Multidetector CT (MDCT) imaging was performed on Siemens 16 Slice MDCT machine. Multiplanar reformation and three-dimensional reconstruction were done wherever necessary.

Results:
20% were diagnosed to have meningitis, 10% had Intraparenchymal haemorrhage and Intraventricular extension, 12% had aqueduct stenosis, and 12% had communicating hydrocephalus. In the study, 40% of them had communicating-type hydrocephalus or extraventricular obstructive hydrocephalus and 60% had obstructive hydrocephalus. On the CT scan, it was observed that at the lateral ventricle, dilatation was observed in four regions. Frontal horn dilatation (98%), body dilatation (98%), and 100% dilatation were seen at the temporal horn and occipital horn. Among 100 patients, 14% had cortical thinning and thus were classified as severe hydrocephalus with a poor prognosis, and 20% had periventricular edema.

Conclusion:
CT is the best means of obtaining images as it is easily available, fast, reliable, and compatible with standard life support devices.
Correlation between Cervical Spine Posture and Hand Grip Strength in Healthy Collegiate Population
Authors: Chauhan Rashmi , Gujral Tanya 
Published: August 2023

Introduction:
Natural lordotic curves in the cervical spine, which gradually curve back into the apex of the chest and upper back at the base of the skull, are indicative of a healthy cervical spine. Hand grip strength can be determined by determining the amount of maximum force that the hand can squeeze against a dynamometer. Grip strength determines how tightly and securely one can grasp objects. Therefore, this study looked at the relationship between hand grip strength and cervical spine position in a healthy collegiate population.

Objective:
To study the correlation between cervical spine posture and hand grip strength in healthy collegiate population.

Methodology:
Total 100 male and female subjects. The subjects for the study were included based on inclusion and exclusion criteria. After explaining the benefits, objectives, and purpose of the study in detail, they were asked to complete the screening form and consent form to conduct the study on the impact of cervical spine position on hand grip strength in a healthy collegiate population.

Results:
Maximum voluntary contraction stands for Maximum voluntary contraction (MVC) T1, T2, and T3 are highly correlated. There is a weak correlation of MVC with the degree of angle of craniovertebral angle (CVA).

Conclusion:
This study concluded a positive and statistically significant link between body mass index and MVC and CVA, but not between MCV and CVA.
Early Verse Conventional Ambulation on Postoperative Pain among Women with Lower Segment Cesarean Section
Authors: Negi Versha , Mohanta Bijaya , Pareek Shatrughan 
Published: August 2023

Introduction:
A cesarean section is a surgical procedure by which one or more babies are delivered through an incision made on a mother’s abdomen and uterus. In post cesarean section phase, early ambulation and oral intake are need to be encouraged after declined effects of anesthesia. The present study was conducted with aim to assess the effectiveness of early ambulation on postoperative pain among the women with a lower segment cesarean section.

Materials and Methods:
The study design was quasi-experimental design and 60 subjects were enrolled by convenient sampling technique. In experimental group, the pain level was assessed after performing breathing exercise, moving legs and hands, upright sitting position, stand and walk with and without support after 10 h of surgery for first 3 postoperative days. While in control group, the mothers were ambulated after 24 h of surgery as per the hospital protocol.

Results:
There was a significant difference (P < 0.001) between the mean postoperative pain scores after early ambulation among experimental on day 1st, day 2nd, and day 3rd. There was a significant decline in pain scores in experimental group compared to control group (P < 0.001) with days progresses.

Conclusion:
The early ambulation was significantly effective in reduce postoperative pain scores among the mothers after cesarean section. The present approach may be adopted for the mothers to decline the need of analgesics during postoperative period.
A Five Year Retrospective Study of Oral Potentially Malignant Disorders (Opmds) and Oral Squamous Cell Carcinoma (OSCC) and their Associated Risk Factors
Authors: Anwar Sana , Tyagi Nutan , Mathias Yulia L. , Javed Danish 
Published: August 2023

Background:
Oral squamous cell carcinoma (OSCC) is generally converted from precancerous conditions. The conversion rates are mainly linked to various addiction habits and sometimes to sociodemographic profile of patients. The clinical spectrum of oral potentially malignant disorders (OPMDs) varies between geographical districts or from place to place within the same country. The prevalence of this particular malignancy may be reduced by prompt diagnostic and therapeutic action.

Aims and Objectives:
We focused on the data associated with histo-pathological types of lesion in relation to certain sociodemographic profile and addiction habits in the targeted population.

Materials and Methods:
We performed 5 years retrospective cross-sectional study from January 2013 to December 2017 in the oral pathology department in systematic manner. Data were collected and compiled in Microsoft Excel and were analyzed through SPSS software. Chi-square, Student’s t-test, and Pearson’s correlation tests were used to determine the significance of study parameters between groups.

Results:
Our study suggests a more common relationship of lichen planus with gutkha, pan, and mixed habit; leukoplakia with bidi smoking and mixed habit; verrucous leukoplakia with bidi and cigarette smoking and gutkha chewing; oral submucous fibrosis with pan and gutkha; mild and moderate dysplasia with bidi and alcohol consumption; well-differentiated OSCC and moderately differentiated OSCC with tobacco intake and/or alcohol and poorly differentiated OSCC with alcohol, pan, and bidi.

Conclusion:
OPMDs and OSCC are more associated with various addiction habits. Cessation of these habits along with early intervention may reduce the burden of disease.
Echocardiographic Evaluation of Cardiac Function in Infants of Mothers with Diabetes
Authors: Fatima Maryam , Abqari Shaad , Ali Syed Manazir , Hakim Seema 
Published: August 2023

Introduction:
A large number of pregnancies are complicated by diabetes mellitus in the mother which is associated with the risk of various cardiac structural and functional complications in the neonates. A diagnostic tool is needed to detect these dysfunctions early. In contrast to conventional pulsed-wave Doppler, which is influenced by heart rate and the impact of volume changes on transmitral flow, tissue Doppler imaging is the mode of echocardiography that is relatively independent of the loading state. Two-dimensional (2D) speckle-tracking echocardiography-derived strain imaging is a new technology increasingly being used to estimate cardiac systolic and diastolic dysfunction and has superior prognostic value for predicting major adverse cardiac events.

Objective:
The objective of this study was to evaluate cardiac function in neonates of mothers with diabetes on echocardiography and differences in the extent of cardiac dysfunction between neonates of well-controlled and poorly controlled mothers with diabetes.

Methods:
This is a cross-sectional observational study which was done on 152 neonates born to mothers with diabetes (22 overt vs. 130 gestational and 23 well-controlled vs. 129 poorly controlled) and 96 born to nondiabetic mothers. Three modes of echocardiography, i.e. M-mode, Doppler (pulsed wave and tissue), and 2D speckle-tracking echocardiography, were done and cardiac functions were compared among different groups.

Results:
Infants of diabetic mothers (IDMs) had lower ejection fraction on M-mode echocardiography and lower values of global longitudinal strain on 2D speckle-tracking echocardiography along with significantly lower values of mitral and tricuspid E velocity and E/A ratio with higher values of A velocity on pulsed-wave Doppler. Tissue Doppler showed higher left ventricle E/E’ in IDM implying more systolic as well as diastolic dysfunction in IDM as compared to non-IDM. In neonates born to mothers with poorly controlled diabetes, Doppler showed lower values of mitral and tricuspid E/A ratio and left ventricle E’/A’ ratio signifying more diastolic dysfunction as compared to neonates born to mothers having good glycemic control. Similarly, neonates born to mothers with pregestational diabetes had significantly deranged systolic and diastolic functions.

Conclusions:
IDMs have significant cardiac dysfunction on echocardiography which is also related to the degree of glycemic control and onset of diabetes.
Electrochemical micromachining and parameter optimization on AZ31 alloy—ANN and TOPSIS techniques
Authors: Sivashankar N. , Thanigaivelan R. , G. Saravanan K. 
Published: August 2023

ABSTRACT. Electrochemical micromachining (ECM) is a nontraditional method used for machining operations in hard and light materials with fixed or varying parameters. In this study, magnesium AZ31 alloy was micro machined using two types of electrolyte supply systems, namely electrolyte flooding and minimum quantity electrolyte (MQE). Experimental investigations were performed using TOPSIS and artificial neural network (ANN) techniques with types of electrolyte supply system, electrolyte concentration (EC), duty cycle (%), and machining voltage (V) as the input parameters, and material removal rate (MRR) and over cut (OC) as the outputs. Single and multi-objective parameter optimization was performed using Taguchi, TOPSIS, and ANN techniques. The machined microholes were analyzed using scanning electron microscopy. According to the TOPSIS results, under optimal conditions, a high MRR value and minimum OC of 1.282 μm/s and 66 μm, respectively, were obtained. The results of TOPSIS were verified using the developed ANN architecture.

KEY WORDS: Magnesium, AZ31 alloy, Electrochemical micromachining, Optimization, TOPSIS, ANN
Bull. Chem. Soc. Ethiop. 2023, 37(5), 1263-1273.
DOI: https://dx.doi.org/10.4314/bcse.v37i5.17
Ultrasound-assisted dispersive liquid-liquid microextraction approach for preconcentration of acyclovir as antiviral drug in dosage forms prior to spectrophotometric determination
Authors: H. Al-Bagawi Amal , El Sheikh Ragaa , M.A. Salem Osama , M. Abdel Fattah Ghada , M. Garoub Mohannad , A. Gouda Ayman 
Published: August 2023

ABSTRACT. For acyclovir (ACV) determination in bulk and dosage forms, quick, sensitive, straightforward, and eco-friendly ultrasound-assisted dispersive liquid-liquid microextraction (UA-DLLME)-based spectrophotometric method has been created and validated. ACV with 1,2-naphthoquine-4-sulfonate (NQS) react in alkaline medium to produce a yellow-colored product, which is the basis of the newly created method. Investigation and optimization were done on the crucial experimental variables influencing ACV's extraction effectiveness. At λmax = 495 nm, the minuscule organic droplets were detected. The linearity was present from 0.1 to 3.0 μg/mL under ideal circumstances, with a linear correlation coefficient of 0.9995. The detection limit was 0.03 μg/mL and quantification limit was 0.1 μg/mL. 22.50 was the enrichment factor. Relative standard deviation (RSD%) as accuracy at 2.0 μg/mL of ACV was 1.0%, with good recovery (99.30%). The developed UA-DLLME method was effectively used to determine the ACV in dosage forms, and the validation was evaluated. Results from the suggested technique for dosage forms and pure ACV were in excellent agreement with the results from the official method.

KEY WORDS: Ultrasound-assissted, Dispersive liquid–liquid microextraction, Acyclovir, Spectrophotometry, Dosage forms
Bull. Chem. Soc. Ethiop. 2023, 37(5), 1081-1092.
DOI: https://dx.doi.org/10.4314/bcse.v37i5.2
Determination of total phenolic, total flavonoid, ascorbic acid contents and antioxidant activity of pumpkin flesh, peel and seeds
Authors: Hagos Mulu , Singh Chandravanshi Bhagwan , Redi-Abshiro Mesfin , Ele Yaya Estifanos 
Published: August 2023

ABSTRACT. Pumpkins are increasingly regarded as functional foods since they contain valuable nutrients and bioactive substances that have positive health effects. The number of bioactive components depends on the origins and parts of the pumpkin, which define its antioxidant capacity. This study evaluated the total phenolic, total flavonoid, and ascorbic acid content and antioxidant activities of three parts of pumpkin from four different sample origins and investigated the correlation between them. The content of bioactive components in pumpkin from Dukem, Ethiopia, was highest in the flesh, peel, and seeds compared to the other sample areas. The Pearson correlation result indicated a strong relationship between the total phenolic, flavonoid, and ascorbic acid contents of pumpkin and their respective antioxidant activities. This study found that the total phenolic, total flavonoid, and ascorbic acid contents and antioxidant activity varied across the pumpkin sample sources and pumpkin parts.

KEY WORDS: Pumpkin, Flavonoid, Phenolic, Ascorbic acid, Antioxidant activity, Ethiopia

Bull. Chem. Soc. Ethiop. 2023, 37(5), 1093-1108.
DOI: https://dx.doi.org/10.4314/bcse.v37i5.3
Bimbingan Teknis Renovasi Mushollah Roudlotul Jannah di Desa Watuagung kecamatan Bungah Kabupaten Gresik
Authors: Kustori Kustori , Hartono Hartono , Suryono Wiwid , Irfansyah Ade 
Published: August 2023

Musholla Roudlotul Jannah merupakan mushollah yang ramai dengan berbagai kegiatan keagamaan, seperti sholat Jumat, sholat Tarawih dan kajian kajian keilmuan yang rutin dilakukan oleh DKM Musholla Roudlotul Jannah. Semakin ramainya aktivitas kegiatan dan padatnya jamaah, DKM Musholla Roudlotul Jannah berupaya melakukan renovasi masjid untuk dapat memenuhi dan menampung semua jamaah yang datang. Tujuan penulisan ini adalah menuliskan kegiatan Pengabdian Masyarakat yang dilakukan oleh Tim abmas Politeknik Penerbangan surabaya dalam pendampingan renovasi Musholla Roudlotul Jannah. Metode pelaksanaan adalah dengan pendekatan desain, gagasan desain berdasarkan pada kegiatan, perilaku, dan aktivitas yang berlangsung di Musholla Roudlotul Jannah. Hasil yang didapatkan dari pendampingan pembanguan Musholla Roudlotul Jannah ini adalah renovasi atap, penggantian ubin, peremjaan cat dinding, pemberian papan nama mushollah, pemasangan lampu jalan menuju mushollah, Selain dari bentuk fisik ada pula yang diberikan oleh para donatur berupa pengadaan karpet mushollah, alat sholat, dan juga pengadaan al-quran sebagai sarana untuk memajukan TPQ.
Guía práctica para la solicitud de marcadores humorales de autoinmunidad y estudios genéticos en diabetes mellitus
Authors: Valdez Silvina , Alonso Amorín Miguel Ángel , Álvarez Yuseff María Fernanda , Andreone Luz , Cerrone Gloria , Ledesma Iris Mabel , Matejic Alejandra , Pelayo Laura , Pelone Marcelo Javier , Trabucchi Aldana , Frechtel Gustavo 
Published: August 2023

La diabetes mellitus (DM) es una enfermedad heterogénea que presenta fenotipos clínicos diversos, todos con hiperglucemia. Históricamente se han utilizado cuatro factores para identificar esta diversidad: la edad de inicio, la gravedad de la enfermedad o grado de pérdida de la función de la célula beta, el grado de resistencia a la insulina y la presencia de autoanticuerpos asociados a la enfermedad.
Actualmente, los parámetros empleados para clasificar los diferentes tipos de DM dificultan el diagnóstico y tratamiento de los pacientes. Las distintas presentaciones clínicas requieren una clasificación diagnóstica más eficaz para un abordaje terapéutico más preciso, valiéndose del avance de la inmunogenética y la bioquímica clínica.
Esta guía está orientada a clasificar con precisión las presentaciones clínicas que a menudo generan incertidumbre dentro de los dos tipos principales de DM.
Estágio em Terapia Ocupacional: potencialidades e desafios da telessaúde/ Fieldwork activity in occupational therapy: potential and challenges of telehealth
Authors: Schander da Rocha Camila , Da Silva Cassais Tatiane , Noronha Barbosa Irene Gabriela , Ricci Éllen Cristina 
Published: August 2023

Contextualização: O presente artigo apresenta e analisa vivências de estágio supervisionado de Terapia Ocupacional em Saúde Mental, realizadas por telessaúde durante a pandemia COVID-19. Processo de Intervenção: As ações apresentadas foram desenvolvidas em um Centro de Atenção Psicossocial tipo I no interior do Ceará, através de videochamadas com duas usuárias, estagiárias e a terapeuta ocupacional do serviço. Análise crítica da prática: O processo de intervenção foi construído em conjunto com as duas mulheres e as estagiárias, que trouxeram para o espaço remoto instrumentos já conhecidos pela Terapia Ocupacional no presencial. Síntese de considerações: Dessa forma, este trabalho pretende abordar os desafios e potencialidades da telessaúde, bem como fomentar seu uso como recurso da Terapia Ocupacional para promover transformações no cotidiano. Palavras-chave: COVID-19. Saúde Mental. Terapia Ocupacional. TelessaúdeAbstract Contextualization: This paper presents and analyzes supervised fieldwork experiences in Occupational Therapy in Mental Health, carried out by telehealth during the COVID-19 pandemic. Intervention Process: The actions presented were developed in a Type I Psychosocial Care Center in Ceará through video calls with two clients, the fieldwork students and the occupational therapist from the service. Critical analysis of practice: The intervention process was collaboratively built with the clients and the students, who used in the remote context instruments already known in face-to-face occupational therapy. Synthesis considerations: This paper aims to address the challenges and potential of telehealth and to encourage its use as a resource of occupational therapy to promote changes in everyday life.Keywords: COVID-19. Mental Health. Occupational Therapy. Telehealth. Resumen Contextualización: Este artículo presenta y analiza las experiencias de práctica profesional supervisadas en Terapia Ocupacional en Salud Mental, realizadas por telehealth durante la pandemia de COVID-19. Proceso de intervención: Las acciones presentadas se desarrollaron en un Centro de Atención Psicosocial tipo I en el interior de Ceará, mediante videollamadas con dos usuarios, aprendices y el terapeuta ocupacional del servicio. Análisis crítico de la práctica: El proceso de intervención se construyó junto a las dos mujeres y las aprendices, quienes llevaron al espacio remoto instrumentos ya conocidos por la Terapia Ocupacional en persona. Resumen de consideraciones: Así, este trabajo tiene como objetivo abordar los desafíos y potenciales de la telesalud, así como promover su uso como recurso de la Terapia Ocupacional para promover cambios en la vida diaria.Palabras clave: COVID-19. Salud Mental. Terapia Ocupacional. Telesalud
Ensino em saúde e metodologias ativas: uma construção acadêmica e artística de “degraus” individuais e coletivos com destino à aprendizagem e transformação social
Authors: Souza Marina Batista Chaves Azevedo de , Duque Andrezza Marques 
Published: August 2023

Objetivo: Pretende-se refletir sobre as potencialidades de uma formação graduada inserida em um campus universitário que possui como premissa filosófica a utilização de metodologias ativas de ensino. Descrição da imagem: Trata-se da imagem de uma escada localizada no ambiente universitário, a qual foi reformada/pintada pela comunidade acadêmica como estudantes, docentes, técnicos, funcionários terceirizados. Essa construção artística, em nossa reflexão, simboliza o que é o conhecimento construído através de metodologias ativas - um exercício autodirigido, coletivo e com o objetivo de proporcionar a “subida” para a formação. Ainda, compreende-se a arte e a educação como potencializadoras de processos de transformação social.Palavras-chave: Terapia Ocupacional. Ensino. Arte. UniversidadesAbstractAim: It is intended to reflect about the potentialities of a graduation course that is inserted in a university campus that have, as a philosophic premise, the use of active methodologies. Image description: Is the image of stairs in the university, that was painted by students, professors, and university workers. This artistic construction represents the concreteness that is the knowledge built by active methodologies, a process that happens in a self-directed and collective form, with the aim to propose the "climb" to the final of the graduation course. We consider art and education as good resources to produce social transformation.Keywords: Occupational Therapy. Teaching. Art. Universities. ResumenObjetivo: Se pretende reflexionar sobre las potencialidades de una educación de posgrado inserta en un campus universitario que tiene como premisa filosófica el uso de metodologías activas. Descripción de la imagen: Es la imagen de las escaleras de la universidad, que fue pintada por estudiantes, profesores y trabajadores universitarios. Esta construcción artística representa la concreción de lo que es un conocimiento construido paulatinamente a través de metodologías activas, que sucede de manera autodirigida y colectiva, con el objetivo de brindar la “ascensión” para la formación. Aun así, el arte y la educación se entienden como potencializadores transformación social.Palabras clave: Terapia Ocupacional. Enseñando. Arte. Universidades.