bluuebunny/crossref_metadata_2025_split huggingface dataset:
Consistency analysis of two US techniques for evaluating hepatic steatosis in patients with metabolic dysfunction-associated steatotic liver disease
Authors: Chen Fei , An Jingjing , Deng Long , Wang Jing , He Ruiling 
Published: January 2025

Abstract
Background
US tools to quantify hepatic steatosis have recently been made clinically available by different manufacturers, but comparative data on their consistency are lacking.

Objective
US tools to quantify hepatic steatosis have recently been made clinically available by different manufacturers, but comparative data on their consistency are lacking. The aim of our study was to compare the diagnostic consistency for evaluating hepatic steatosis by two different US techniques, hepatorenal index by B-mode Ratio and attenuation coefficient by attenuation imaging (ATI).

Methods
Patients with suspicion or previously diagnosed of metabolic dysfunction-associated steatotic liver disease (MASLD) who attended fatty liver consulting room from June 2023 to September 2023 were prospectively recruited. Patients underwent two different US techniques of B-mode Ratio and ATI, and laboratory test were collected. According to previously proposed cut-off values, B-mode Ratio ≥ 1.22, 1.42, 1.54, and ATI ≥ 0.62, 0.70, and 0.78 dB/cm/MH were used for assessing of mild, moderate, and severe hepatic steatosis, respectively. Kappa consistency test was used to evaluate the consistency of hepatic steatosis.

Results
A total of 62 patients were enrolled, including 44 males (71.0%) with an age of (41 ± 13) years and a body mass index of (27.0 ± 3.5) kg/m2. In the hyperlipidemia group, the B-mode Ratio and ATI were significantly higher than those in the non-hyperlipidemia group, with values of 1.68 ± 0.39 vs. 1.28 ± 0.35 (p = 0.001) and 0.74 ± 0.12 dB/cm/MH vs. 0.64 ± 0.11 dB/cm/MH (p = 0.005), respectively. The correlation coefficient between B-mode Ratio and ATI was 0.732 (p < 0.001). Using B-mode Ratio and ATI as diagnostic criteria for MASLD, the proportion of patients with MASLD was 79% and 82%, respectively. The Kappa coefficient for assessing MASLD was 0.90 (p < 0.001). Furthermore, these two different US techniques were used for grading hepatic steatosis, with no, mild, moderate, and severe steatosis accounting for 21%, 18%, 13%, and 48%, as well as 18%, 29%, 22%, and 31%, respectively. The linear weighted Kappa coefficient for staging hepatic steatosis was 0.78 (95% confidence interval: 0.68–0.87, p < 0.001).

Conclusion
The non-invasive methods of two different US techniques based on B-mode Ratio and ATI have good consistency for evaluating hepatic steatosis, and can be used for large-scale community screening.
Awareness of cardiovascular disease risk and care received among Australian women with a history of hypertensive disorders of pregnancy: a cross-sectional survey
Authors: Slater Kaylee , Taylor Rachael , Collins Clare E. , Hutchesson Melinda 
Published: January 2025

Abstract
Background
Women with a history of hypertensive disorders of pregnancy (HDP), including chronic hypertension, gestational hypertension, and preeclampsia have an increased risk of cardiovascular disease (CVD). Current research suggests that general practitioners are unaware of women’s HDP history, and although ideally placed to follow-up with these women, there is limited understanding of current CVD prevention practices in women after HDP. Additionally, preeclampsia confers a higher CVD risk compared to other types of HDP, and Australian research suggests that lower socioeconomic status (SES) is associated with a higher incidence of both HDP and CVD. Therefore, the aim of the analysis was to investigate awareness of CVD risk and care received from health professionals among women with a history of HDP and examine differences between type of HDP and SES.

Methods
Analysis of a cross-sectional survey of 293 Australian women with a history of HDP (from 2017 onwards). Data were analysed using basic descriptive statistics. To assess differences in HDP type and SES, one-way ANOVA was used to assess continuous variables and χ2 tests for categorical variables, with P < 0.05 considered statistically significant.

Results
Most women with a history of HDP were unaware of their increased CVD risk (68%). Women with a history of preeclampsia, gestational hypertension or preeclampsia were more aware of CVD risk compared to those with chronic hypertension (p = 0.02). Regardless of HDP type or SES, women post-HDP were less likely to receive assessment and management of lifestyle CVD risk factors compared to blood pressure. Most women felt supported in managing stress and mental health, but not for managing body weight, smoking and sleep.

Conclusions
Women with a history of HDP are unaware of their increased CVD risk and are not receiving recommended CVD preventative care, irrespective of HDP type and/or SES. Findings should be used to inform development of tailored CVD prevention interventions in the primary care setting for women following HDP.
Fracture resistance and mode of failure of modified Polyether-ether-ketone versus lithium disilicate endocrowns
Authors: Kharboush Mohamed G. A. , Othman Hesham I. , Aldamaty Mohamed F. , Alameldin Ahmed M. L. 
Published: January 2025

Abstract
Purpose
The current study aimed to compare modified Polyether-ether-ketone's fracture resistance and failure mode versus lithium disilicate glass–ceramic endocrowns.

Materials and methods
A total of 16 butt-joint endocrown specimens on mandibular second molar teeth were fabricated and divided into two equivalent groups; Pressable modified Polyether-ether-ketone (PEEK) (BioHPP®) and Pressable lithium disilicate glass ceramic (IPS e.max® Press). A computer-aided design/computer-aided manufacturing system was used to digitally create and milled wax patterns. Final restorations were cemented each to its corresponding prepared tooth. Thermomechanical cycling loading representing one year of clinical service was done in a chewing simulator. Fracture resistance was evaluated utilizing a universal testing machine. The failure mode was evaluated by inspecting fractured surfaces using a Stereomicroscope and further examined by a Scanning Electron Microscope (SEM) amongst both groups.

Results
A statistically significant variation in fracture resistance was recorded with a mean load of (2762.96 ± 216.15 N) for modified PEEK and (2175.91 ± 267.72 N) for lithium disilicate glass–ceramic endocrowns.

Conclusion
Modified PEEK endocrowns have higher fracture resistance than lithium disilicate glass–ceramic endocrowns. Moreover, the likeliness of catastrophic fracture in molars receiving endodontic treatment restored by modified PEEK is less than teeth restored with lithium disilicate glass ceramics.
Translation, cross-cultural adaptation and validation of the Chinese version of supportive and palliative care indicators tool (SPICT-CH) to identify cancer patients with palliative care needs
Authors: Xie Zhishan , Tang Siyuan , Johnson Claire E. , Xiao Lin , Ding Jinfeng , Huang Chongmei 
Published: January 2025

Abstract
Introduction
People diagnosed with cancer are the most frequent users of palliative care. However, there are no specific standards for early identifying patients with palliative care needs in mainland China. The Supportive and Palliative Care Indicators tool (SPICT) can identify patients with cancer who are in need of palliative care across healthcare settings.

Objective
To translate, cross-cultural adapt the SPICT and validate it among cancer patients with palliative care needs in a Chinese healthcare context.

Method
We translated and culturally adapted the SPICT from English into Chinese, following both Beaton’s and WHO’s recommendations: (1) initial translation, (2) synthesis, (3) back translation, (4) expert committee review, and (5) pretest. The psychometric properties (e.g., content validity, internal consistency, and inter-rater reliability) were analyzed. Convenience sample was used to recruit 212 hospitalized cancer patients between January and August 2023. Their needs were assessed by two nurses within 24hours to determine the inter-rater reliability and stability of the Mandarin version of SPICT (SPICT-CH).

Results
All of 36 items were retained in response to expert review. The Scale-Content Validity Index/Ave (S-CVI/Ave) of the SPICT-CH was 0.98, demonstrating very strong content validity. The SPICT-CH exhibited good coherence (Cronbach’s alpha = 0.76) and reliability (Kappa = 0.71, 95% CI 0.71-0.72, P < 0.05).

Conclusion
The SPICT-CH has good content validity and acceptable reliability among cancer patients within a Chinese hospital setting. This instrument can be effectively integrated into routine clinical practice to early identify patients who need palliative care in mainland China.
Unraveling the power of sense of coherence: a key predictor of symptom severity among depressive disorders clients
Authors: Taha Samah Mohamed , El-Sayed Mona Metwally , Khedr Mahmoud Abdelwahab , El-Ashry Ayman Mohamed , Abdelraof Azza Ibrahim , Sonbol Hassan Mohammed , Hawash Manal Mohammed , Elhay Eman Sameh Abd 
Published: January 2025

Abstract
Background
Despite advancements in therapies, the severity of depressive symptoms continues to challenge psychiatric nurses. However, research has indicated that a higher sense of coherence (SOC) can act as a protective factor against the development of diseases and promote faster recovery.

Aim
This study aimed to investigate whether SOC could serve as an indicator of depressive symptom severity among clients with depression.

Design
The study employed a cross-sectional design and followed the STROBE checklist for reporting observational studies.

Methods
A convenient sample of 169 clients with depression participated in the study. The researchers utilized the Antonovsky Sense of Coherence Scale-29 and the Beck Depression Inventory-II to assess SOC and depressive symptoms, respectively.

Results
The study findings indicated that a substantial proportion of the participants (35.5%) had low Sense of Coherence (SOC) levels, associated with higher depressive symptoms. The severity of depression showed a significant negative correlation with difficulties in understanding and finding meaning in life and challenges in effectively coping with life’s demands (r = -0.626, p < 0.001). The regression analysis revealed that for every one-unit increase in SOC, there was a corresponding decrease of 0.5 units in depressive symptoms. The SOC variable accounted for 39.1% of the variance in depressive symptoms severity.

Conclusion
Psychiatric nurses should consider implementing interventions to enhance SOC, such as Life Skills Training (LST), psychoeducation, cognitive-behavioral therapy, and mindfulness practices, particularly for depressive disorder clients with a poor sense of coherence.
Multimorbidity clusters and their associations with health-related quality of life in two UK cohorts
Authors: Steell Lewis , Krauth Stefanie J. , Ahmed Sayem , Dibben Grace O. , McIntosh Emma , Hanlon Peter , Lewsey Jim , Nicholl Barbara I. , McAllister David A. , Smith Susan M. , Evans Rachael , Ahmed Zahira , Dean Sarah , Greaves Colin , Barber Shaun , Doherty Patrick , Gardiner Nikki , Ibbotson Tracy , Jolly Kate , Ormandy Paula , Simpson Sharon A. , Taylor Rod S. , Singh Sally J. , Mair Frances S. , Jani Bhautesh D. ,   the PERFORM research team
Published: January 2025

Abstract
Background
Identifying clusters of multiple long-term conditions (MLTCs), also known as multimorbidity, and their associated burden may facilitate the development of effective and cost-effective targeted healthcare strategies. This study aimed to identify clusters of MLTCs and their associations with long-term health-related quality of life (HRQoL) in two UK population-based cohorts.

Methods
Age-stratified clusters of MLTCs were identified at baseline in UK Biobank (n = 502,363, 54.6% female) and UKHLS (n = 49,186, 54.8% female) using latent class analysis (LCA). LCA was applied to people who self-reported ≥ 2 LTCs (from n = 43 LTCs [UK Biobank], n = 13 LTCs [UKHLS]) at baseline, across four age-strata: 18–36, 37–54, 55–73, and 74 + years. Associations between MLTC clusters and HRQoL were investigated using tobit regression and compared to associations between MLTC counts and HRQoL. For HRQoL, we extracted EQ-5D index data from UK Biobank. In UKHLS, SF-12 data were extracted and mapped to EQ-5D index scores using a standard preference-based algorithm. HRQoL data were collected at median 5 (UKHLS) and 10 (UK Biobank) years follow-up. Analyses were adjusted for available sociodemographic and lifestyle covariates.

Results
LCA identified 9 MLTC clusters in UK Biobank and 15 MLTC clusters in UKHLS. Clusters centred around pulmonary and cardiometabolic LTCs were common across all age groups. Hypertension was prominent across clusters in all ages, while depression featured in younger groups and painful conditions/arthritis were common in clusters from middle-age onwards. MLTC clusters showed different associations with HRQoL. In UK Biobank, clusters with high prevalence of painful conditions were consistently associated with the largest deficits in HRQoL. In UKHLS, clusters of cardiometabolic disease had the lowest HRQoL. Notably, negative associations between MLTC clusters containing painful conditions and HRQoL remained significant even after adjusting for number of LTCs.

Conclusions
While higher LTC counts remain important, we have shown that MLTC cluster types also have an impact on HRQoL. Health service delivery planning and future intervention design and risk assessment of people with MLTCs should consider both LTC counts and MLTC clusters to better meet the needs of specific populations.
Real-time PCR detection of Coxiella burnetii in dairy products in Kwara State, Nigeria: a public health concern
Authors: Elelu Nusirat , Chinedu Nwachukwu Raymond , Yakub-Obalowu Balkees A. , Odetokun Ismail A. , Al-Mustapha Ahmad I. 
Published: January 2025

Abstract
Background
Coxiella burnetii is the etiological agent of Q fever in humans, a zoonosis of increasingly important public health concern. The disease results in significant economic losses to livestock farmers and its presence in ready-to-eat dairy products poses a public health threat to consumers.

Aim
This study aimed to detect Coxiella burnetii in dairy products in Kwara State, Nigeria.

Methods
A cross-sectional study was performed to estimate the apparent and true prevalence of C. burnetii in dairy cattle in selected local government areas (LGAs) of Kwara State, Nigeria. A total of 51 traditional Fulani transhumance farms were sampled across three regions: 27 farms in Ifelodun LGA, 9 in Ilorin East LGA, and 15 in Moro LGA. Four pooled milk samples were collected aseptically from lactating cows on each farm, totaling 204 milk samples. We screened the pathogen using real-time PCR that targeted the IS1111 element in the 51 pooled raw milk samples from selected farms and 18 cheese samples from rural markets within the study area.

Results
The overall apparent prevalence of C. burnetii in milk and cheese was 18.8%. Both dairy products showed similar prevalence with a relatively higher positivity rate in cheese (22.2%, n = 4/18) than in raw milk samples (17.6%, n = 9/51). There were significant differences in the burden of C. burnetii in milk between the three LGAs with higher prevalence in Moro LGA (p < 0.05).

Conclusions
The presence of C. burnetii in dairy products poses a direct risk of milk-borne zoonotic disease transmission to humans. Public education for the stakeholders in the dairy value chain should be intensified and the public should desist from consumption of unpasteurized milk. More molecular studies are needed to further study and characterize the C. burnetii genotypes in Nigeria.
The association between individual radiographic findings and improvement after chiropractic spinal manipulation and home exercise among older adults with back-related disability: a secondary analysis
Authors: Maiers Michele J. , Albertson Andrea K. , Major Christopher , Mendenhall Heidi , Petrie Christopher P. 
Published: January 2025

Abstract
Background
Some chiropractors use spinal x-rays to inform care, but the relationship between radiographic findings and outcomes is unclear. This study examined the association between radiographic findings and 30% improvement in back-related disability in older adults after receiving 12 weeks of chiropractic spinal manipulation and home exercise instruction.

Methods
This IRB-approved secondary analysis used randomized trial data of community-dwelling adults age ≥ 65 with chronic spinal pain and disability. Data were collected during the parent trial between January 2010-December 2014. The primary outcome of the parent study was ≥ 30% improvement in Oswestry Disability Index (ODI) at 12 weeks, a clinically important response to care. In this secondary analysis, two chiropractic radiologists independently assessed digital lumbar radiographs for pre-specified anatomic, degenerative, and alignment factors; differences were adjudicated. The unadjusted association between baseline radiographic factors and 30% ODI improvement was determined using chi-square tests.

Results
From the parent trial, 120 adults with baseline lumbar radiographs were included in this study. Mean age was 70.4 years (range 65–81); 59.2% were female. Mean baseline disability (ODI = 25.6) and back pain (5.2, 0–10 scale) were moderate. Disc degeneration (53.3% moderate, 13.3% severe), anterolisthesis (53.3%), retrolisthesis (36.6%) and scoliosis (35.0%) were common among the participant sample. After 12-weeks of treatment, 51 (42.5%) participants achieved 30% improvement in back disability. No alignment, degenerative, or anatomic factors were associated with ODI improvement at 12 weeks (all p > 0.05), regardless of severity of radiographic findings.

Conclusion
We found no association between a predetermined subset of radiographic findings and improvement in back-related disability among this sample of older adults. As such, this study provides preliminary data suggesting that imaging may be unhelpful for predicting response to chiropractic spinal manipulation and home exercise.
Therapeutic potential of adipose-derived stem cells for diabetic foot ulcers: a systematic review and meta-analysis
Authors: Elainein Mohamed A. Abu , Whdan Mohamad Mahmoud , Samir Mahmoud , Hamam Nada G. , Mansour Mohamed , Mohamed Mohamed Abdel Mohsen , Snosy Mahmoud Mostafa , Othman Mahmoud Ayman , Sobieh Ahmed Sayed , Saad Mahmoud Gamal , Labna Mohamed A. , Allam Salma 
Published: January 2025

Abstract
Background
As the global prevalence of diabetes mellitus increases, the incidence of non-healing wounds in diabetic patients is expected to rise significantly, according to the International Diabetes Federation (IDF), around 537 million adults currently suffer from diabetes mellitus worldwide and 20% to 30% of individuals with diabetes are hospitalized due to diabetic foot ulcers. Conventional treatments such as traditional dressings often fall short in ensuring satisfactory wound healing, this Meta-analysis investigates the therapeutic potential of Adipose-derived Stem Cells (ADSCs) as a promising strategy for addressing this challenge.

Aims
To Assess the Therapeutic Potential of Adipose-Derived Stem Cells for Managing Diabetic Foot Ulcers compared to conventional lines of treatments.

Methods
The PubMed, SCOPUS, Web of Science Core Collection, Cochrane Library, and ClinicalTrials.gov. databases were searched from January 2000 and December 2023, articles were primarily evaluated regarding their titles and abstracts, then full-text screening was assessed against the inclusion and exclusion criteria by utilizing Rayyan software. The Cochrane risk of bias (RoB 2) assessment tool was used to identify the risk of bias in our included studies. A statistical analysis was performed using Review Manager (RevMan) Version 5 software. Dichotomous data was subjected to risk ratio analysis, while continuous data underwent Mean Difference (MD) evaluation, all was reported with 95% confidence intervals, P value is considered statistically significant if less than 0.05.

Results
Regarding the total healing state, five studies reported that more participants healed completely at the end of the follow-up period in the ADSCs group (Risk ratio = 1.56, 95% CI [1.32, 1.86], P < 0.00001), for the healing rate the overall effect estimate favors the ADSCs group (pooled effect estimate = 1.84, 95% CI [1.51, 2.89], P < 0.00001), and regarding the healing time the pooled mean difference of the studies demonstrated that the ADSCs group required fewer days to heal than the standard care group. (pooled mean difference = −19.33, 95% CI [−37.36, −1.29], P = 0.04).

Conclusion
ADSCs provide favorable healing results and safety compared to standard care for diabetic foot ulcers.
A meta-analysis of epigenome-wide association studies of ultra-processed food consumption with DNA methylation in European children
Authors: Llauradó-Pont Joana , Stratakis Nikos , Fiorito Giovanni , Handakas Evangelos , Neumann Alexander , Barros Henrique , Brantsæter Anne Lise , Chang Kiara , Chatzi Leda , Felix Janine F. , Grazuleviciene Regina , Jaddoe Vincent W. V. , Karachaliou Marianna , Lecorguillé Marion , Lopes Carla , Millett Christopher , McEachan Rosemary R. C. , Papadopoulou Eleni , Slama Remy , Vamos Eszter P. , Vineis Paolo , Vrijheid Martine , Wright John , Voortman Trudy , Bustamante Mariona , Robinson Oliver , Lassale Camille 
Published: January 2025

Abstract
Background/objective
There is limited knowledge on how diet affects the epigenome of children. Ultra-processed food (UPF) consumption is emerging as an important factor impacting health, but mechanisms need to be uncovered. We therefore aimed to assess the association between UPF consumption and DNA methylation in children.

Methods
We conducted a meta-analysis of epigenome-wide association studies (EWAS) from a total of 3152 children aged 5–11 years from four European studies (HELIX, Generation XXI, ALSPAC, and Generation R). UPF consumption was defined applying the Nova food classification system (group 4), and DNA methylation was measured in blood with Illumina Infinium Methylation arrays. Associations were estimated within each cohort using robust linear regression models, adjusting for relevant covariates, followed by a meta-analysis of the resulting EWAS estimates.

Results
Although no CpG was significant at FDR level, we found suggestive associations (p-value < 10–5) between UPF consumption and methylation at seven CpG sites. Three of them, cg00339913 (PHYHIP), cg03041696 (intergenic), and cg03999434 (intergenic), were negatively associated, whereas the other four, cg14665028 (NHEJ1), cg18968409 (intergenic), cg24730307 (intergenic), and cg09709951 (ATF7), were positively associated with UPF intake. These CpGs have been previously associated with health outcomes such as carcinomas, and the related genes are mainly involved in pathways related to thyroid hormones and liver function.

Conclusion
We only found suggestive changes in methylation at 7 CpGs associated with UPF intake in a large EWAS among children: although this shows a potential impact of UPF intake on DNAm, this might not be a key mechanism underlying the health effects of UPFs in children. There is a need for more detailed dietary assessment in children studies and of intervention studies to assess potential epigenetic changes linked to a reduction in UPF in the diet.

Graphical abstract