bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalencia de lesiones musculoesqueléticas en estudiantes de Fisioterapia
Authors: Javier-Rivera Leidy Sofía , Escalante-García Yasmin , Canté-Cuevas Xóchitl Candelaria , Kent-Sulú Martha Patricia 
Published: January 2023

El tipo de estudio que se utilizó en esta investigación fue de tipo cuantitativo, de cohorte transversal; para su análisis se trabajó con una muestra de 25 alumnos y los métodos que se emplearon fue el cuestionario nórdico estandarizado y el método ergonómico de evaluación postural de OWAS. El 84% de la muestra fue de sexo femenino y el 16% masculino; el promedio de edad de +22.44 (DE=±22.44), promedio de horas de prácticas en el laboratorio +5.12 horas, una confiabilidad del instrumento del cuestionario nórdico estandarizado con alfa de Cronbach basados en elementos estandarizados de 0.761 y la confiabilidad del método de OWAS con un alfa de Cronbach de 0.747; se determinó que el 92.8% de los estudiantes presentaron problemas musculoesqueléticos, principalmente en la zona de cuello (45%), hombros (32.5%), espalda baja (52.5%), rodillas (35%) y en los últimos siete días dolor en caderas (32.5%); una sobrecarga de peso se encontró en el nivel 3 de riesgo ergonómico, lo que representó el 32.2%. Estas evaluaciones identificaron la sintomatología inicial de lesiones musculoesqueléticas en los alumnos durante su formación profesional, que repercuten en la edad productiva, lo que genera absentismo y baja producción laboral, constituyéndose un problema de Salud Pública.
Palabras clave:
Ergonómico, OWAS, Cuestionario Nórdico Estandarizado, estudiantes, Fisioterapia.

ABSTRACT
The type of study that was used in this research was quantitative, cross-sectional cohort; For its analysis, a sample of 25 students was used and the methods used were the standardized Nordic questionnaire and the ergonomic method of postural evaluation of OWAS. 84% of the sample was female and 16% male; the average age of +22.44 (SD = ± 22.44), average hours of laboratory practice +5.12 hours, a reliability of the standardized Nordic questionnaire instrument with Cronbach's alpha based on standardized elements of 0.761 and the reliability of the method of OWAS with a Cronbach's alpha of 0.747; It was determined that 92.8% of the students presented musculoskeletal problems, mainly in the neck area (45%), shoulders (32.5%), lower back (52.5%), knees (35%) and in the last seven days pain in hips (32.5%); a weight overload was found in ergonomic risk level 3, which represented 32.2%. These evaluations identified the initial symptoms of musculoskeletal injuries in students during their professional training, which affect their productive age, which generates absenteeism and low labor production, becoming a Public Health problem.
Keywords:
Ergonomic, OWAS, Standardized Nordic Questionnaire, students, Physiotherapy.
Senile dementia and psychiatric stigma among community health service providers and relatives of diagnosed and suspected dementia patients: a cross-sectional study
Authors: Zhang Qiwen , Deng Jing , Luo Huanyue , Wang Li 
Published: January 2023

Background
The number of people suffering from dementia is increasing rapidly in China. Early identification, referral, and intervention for dementia patients within communities are important to public health. However, these measures could be impacted by misconceptions about dementia and associated psychiatric stigma from community health professionals and relatives of dementia patients.

Methods
A cross-sectional survey was conducted on 249 participants, which included community doctors, community nurses, and relatives of diagnosed and suspected dementia patients in Guiyang, China. Participants were recruited through convenient sampling. The Chinese version of Dementia Knowledge Assessment Scale (DKAS) and the Perceived Psychiatric Stigma Scale (PPSS) were used to evaluate the participants’ knowledge of dementia and dementia-related psychiatric stigma.

Results
A total of 249 participants completed the questionnaire. The participants had moderate overall knowledge of dementia and the associated psychiatric stigma. Participants who were ≥45 years old, had a low level of education, had a low monthly income, or gained knowledge of dementia through non-media channels had lower awareness of dementia and stronger psychiatric stigma. In the “Communication & behavior” subscale of DKAS, all participants had a low level of awareness. Relatives of diagnosed and suspected dementia patients had higher total PPSS and “Marital preclusion” subscale scores than community doctors and nurses but lower psychiatric stigma based on the PPSS “Self-deprecation” subscale score.

Conclusions
Despite their profession, community doctors and nurses did not show an absolute advantage over relatives of diagnosed and suspected dementia patients in the dementia knowledge, and they even showed higher psychiatric stigma in some subscales. The self-deprecation subscale is related to the identification with negative labels such as “people with a mental illness are the weak”. This study shows that reducing stigma on the “Self-deprecation” subscale should be a core component of training and educational programs targeted at improving dementia knowledge among community health service providers.
Mass media pressure on physical build, psychological well-being and physical-healthy profile. An explanatory model in adulthood
Authors: Melguizo-Ibáñez Eduardo , González-Valero Gabriel , Badicu Georgian , Grosz Wilhelm Robert , Bazgan Marius , Puertas Molero Pilar 
Published: January 2023

Background
The pressure exerted by the media on mental image, psychological well-being and the physical-dietary sphere is of vital interest in understanding human behavioral patterns at different stages of development. The present research reflects the objectives of developing an explanatory model of the associations between media pressure and physical build on psychological well-being, physical activity and the Mediterranean diet and testing the structural model using a multi-group model according to participants’ stage of adulthood development.

Methods
A descriptive, non-experimental, cross-sectional study was carried out on a sample of 634 participants aged between 18 and 65 years (35.18 ± 9.68). An ad hoc socio-demographic questionnaire, Sociocultural Attitudes Towards Appearance Questtionnaire-4, Psychological Well-Being Scale, Predimed questtionnaire and International Physical Activity Questionnaire-Short Form were used for data collection.

Results
Participants in early adulthood show higher scores for media pressure and for pressure on physical build. It is also observed that participants in middle adulthood show higher scores for psychological well-being and physical activity levels.

Conclusions
In conclusion, it can be seen that there are a large number of physical, physical-health and psychological differences in each of the phases of adulthood.
Bioremediation Tofu Liquid Waste Based on Chemical Oxygen Demand (COD) Parameters
Authors: Isworo Slamet , Oetari Poerna Sri , Prabowo Danu , Cerlyawati Hugi 
Published: January 2023

Background and Objective: The majority of liquid waste generated by the tofu industry in Semarang exceeds the recommended limit. This condition disturbs the ecology of the surrounding environment. so a solution is needed to manage it. The use of bacteria in bioremediation technology has been proven to reduce pollutants produced by the tofu industry. The purpose of this study was to identify specific bacteria and test their ability to bioremediate pollutants from tofu wastewater using the Chemical Oxygen Demand (COD) parameter.
Methodology: Methodology: The study was exploratory and experimental in nature, with the variable ability of degradative bacteria degrading tofu industrial wastewater based on COD parameters. Bacterial identification was performed using the 16S-rRNA Gene Analysis method, genomic DNA extraction with the Quick-DNA Bacterial Miniprep Kit, PCR amplification, and bi-directional sequencing.
Results: The results of the identification of the selected bacteria show that they are molecules of the type nucleic acid with a query length of 1394. with a lineage report and a 93% phylogenetic tree as Bacillus subtilis, Bioremediation test shows that tofu waste can be degraded. The degradation percentage is 17%.
Conclusion: Bacillus subtillis, a bacterium that degrades tofu industrial wastewater, was found as an indigenous bacteria.
An Unexpected Headache: Pituitary Apoplexy in a Patient Admitted with Diabetes Ketoacidosis (DKA)
Authors: ALnageeb Hanadi Babiker , Maeeni Amal Al , Alakkad Ashraf , Qaidy Aseilah Al , Bhat Raghavendra 
Published: January 2023

Background: Pituitary apoplexy is a clinical problem resulting from abrupt pituitary ischemia or hemorrhage. A small proportion of pituitary adenomas manifest as an apoplectic crisis, with pan hypopituitarism, vomiting, nausea, headache, ophthalmoplegia, and visual impairment being the most common symptoms.
Case Report: A 32-year-old diabetic Asian male presented to the emergency department with symptoms of polyuria, polydipsia, persistent vomiting, and diffused abdominal pain. He also reported a recent fever and severe headache, as well as self-limited episodes of blurring of vision and diplopia three months prior. Upon admission, his vitals were stable and he was fully conscious and oriented, though irritable and anxious. On examination, he was found to have third cranial nerve palsy and a dilated pupil with no light reflex. Laboratory tests revealed diabetic ketoacidosis (DKA). A CT scan of the brain revealed a possible invasive pituitary macro adenoma and the patient was referred for further evaluation. He also tested positive for COVID-19. Treatment for DKA was initiated and an MRI scan was scheduled for further evaluation. However, the patient's condition worsened and he was transferred to the ICU, where he was intubated and an MRI indicated a hemorrhagic mass in the pituitary gland. The patient was diagnosed with pituitary apoplexy, and he also received treatment with antibiotics and antiviral medication for suspected encephalitis.
Conclusion: Pituitary apoplexy is a serious condition that requires immediate evaluation and treatment. It can cause permanent damage or death if left untreated. Treatment options include surgery and conservative management with frequent monitoring.
Overvoltages during Single-Phase Earth Fault in Neutral-Isolated Networks (10÷35) kV
Authors: Rzayeva S. V. , Mammadov N. S. , Ganiyeva N. A. 
Published: January 2023

Aims: The purpose of the article is to analyze networks with zero insulation (10 ÷ 35) kV, which have disadvantages that adversely affect the insulation of operating equipment, as a result of which, in modern conditions, it is desirable to improve the operating modes of such networks.
Place and Duration of Study: Department of Electromechanics (Electrical and electronic engineering).
Methodology: To limit the surges that occur in such networks, an arc quenching coil is used, the operation of which is based on two processes: a coil that compensates for the capacitive current, a sharp decrease in the voltage recovery rate in the arc range.
Results: In connection with the above, by carrying out accurate calculations, it is necessary to solve a number of issues on grounding the neutral with active resistance in networks (10÷35) kV: effective grounding of networks, ensuring safety, limiting the impact on communication lines, limitation of emerging surges, ensuring normal operation of switching devices, etc.
Conclusion: 1. Due to the difficulty of obtaining an accurate adjustment when earthing the neutral through an arcing coil, and even under normal conditions, overvoltages in the phases are likely as a result of the displacement of the neutral. 2. Networks with zero insulation (10÷35) kV have disadvantages that adversely affect the insulation of operating equipment, and in modern conditions it is desirable to improve the operating modes of such networks.3. In networks with an isolated neutral (10÷35) kV, the connection of the neutral to earth with active resistance allows you to significantly limit the extreme voltages that may occur in the network.
Revision of the Melanocytic Pathology Assessment Tool and Hierarchy for Diagnosis Classification Schema for Melanocytic Lesions
Authors: Barnhill Raymond L. , Elder David E. , Piepkorn Michael W. , Knezevich Stevan R. , Reisch Lisa M. , Eguchi Megan M. , Bastian Boris C. , Blokx Willeke , Bosenberg Marcus , Busam Klaus J. , Carr Richard , Cochran Alistair , Cook Martin G. , Duncan Lyn M. , Elenitsas Rosalie , de la Fouchardière Arnaud , Gerami Pedram , Johansson Iva , Ko Jennifer , Landman Gilles , Lazar Alexander J. , Lowe Lori , Massi Daniela , Messina Jane , Mihic-Probst Daniela , Parker Douglas C. , Schmidt Birgitta , Shea Christopher R. , Scolyer Richard A. , Tetzlaff Michael , Xu Xiaowei , Yeh Iwei , Zembowicz Artur , Elmore Joann G. 
Published: January 2023

ImportanceA standardized pathology classification system for melanocytic lesions is needed to aid both pathologists and clinicians in cataloging currently existing diverse terminologies and in the diagnosis and treatment of patients. The Melanocytic Pathology Assessment Tool and Hierarchy for Diagnosis (MPATH-Dx) has been developed for this purpose.ObjectiveTo revise the MPATH-Dx version 1.0 classification tool, using feedback from dermatopathologists participating in the National Institutes of Health–funded Reducing Errors in Melanocytic Interpretations (REMI) Study and from members of the International Melanoma Pathology Study Group (IMPSG).Evidence ReviewPracticing dermatopathologists recruited from 40 US states participated in the 2-year REMI study and provided feedback on the MPATH-Dx version 1.0 tool. Independently, member dermatopathologists participating in an IMPSG workshop dedicated to the MPATH-Dx schema provided additional input for refining the MPATH-Dx tool. A reference panel of 3 dermatopathologists, the original authors of the MPATH-Dx version 1.0 tool, integrated all feedback into an updated and refined MPATH-Dx version 2.0.FindingsThe new MPATH-Dx version 2.0 schema simplifies the original 5-class hierarchy into 4 classes to improve diagnostic concordance and to provide more explicit guidance in the treatment of patients. This new version also has clearly defined histopathological criteria for classification of classes I and II lesions; has specific provisions for the most frequently encountered low–cumulative sun damage pathway of melanoma progression, as well as other, less common World Health Organization pathways to melanoma; provides guidance for classifying intermediate class II tumors vs melanoma; and recognizes a subset of pT1a melanomas with very low risk and possible eventual reclassification as neoplasms lacking criteria for melanoma.Conclusions and RelevanceThe implementation of the newly revised MPATH-Dx version 2.0 schema into clinical practice is anticipated to provide a robust tool and adjunct for standardized diagnostic reporting of melanocytic lesions and management of patients to the benefit of both health care practitioners and patients.
How many brain metastases can be treated with stereotactic radiosurgery before the radiation dose delivered to normal brain tissue rivals that associated with standard whole brain radiotherapy?
Authors: Becker Stewart J. , Lipson Evan J. , Jozsef Gabor , Molitoris Jason K. , Silverman Joshua S. , Presser Joseph , Kondziolka Douglas 
Published: January 2023

AbstractIntroductionClinical trial data comparing outcomes after administration of stereotactic radiosurgery (SRS) or whole‐brain radiotherapy (WBRT) to patients with brain metastases (BM) suggest that SRS better preserves cognitive function and quality of life without negatively impacting overall survival. Here, we estimate the maximum number of BM that can be treated using single and multi‐session SRS while limiting the dose of radiation delivered to normal brain tissue to that associated with WBRT.MethodsMultiple‐tumor SRS was simulated using a Monte Carlo – type approach and a pre‐calculated dose kernel method. Tumors with diameters ≤36 mm were randomly placed throughout the contoured brain parenchyma until the brain mean dose reached 3 Gy, equivalent to the radiation dose delivered during a single fraction of a standard course of WBRT (a total dose of 30 Gy in 10 daily fractions of 3 Gy). Distribution of tumor sizes, dose coverage, selectivity, normalization, and maximum dose data used in the simulations were based on institutional clinical metastases data.ResultsThe mean number of tumors treated, mean volume of healthy brain tissue receiving > 12 Gy (V12) per tumor, and total tumor volume treated using mixed tumor size distributions were 12.7 ± 4.2, 2.2 cc, and 12.9 cc, respectively. Thus, we estimate that treating 12–13 tumors per day over 10 days would deliver the dose of radiation to healthy brain tissue typically associated with a standard course of WBRT.ConclusionAlthough in clinical practice, treatment with SRS is often limited to patients with ≤15 BM, our findings suggest that many more lesions could be targeted while still minimizing the negative impacts on quality of life and neurocognition often associated with WBRT. Results from this in silico analysis require clinical validation.
Tryptophan Metabolism Acts as a New Anti‐Ferroptotic Pathway to Mediate Tumor Growth
Authors: Liu Dong , Liang Chun‐hui , Huang Bin , Zhuang Xiao , Cui Weiwei , Yang Li , Yang Yinghong , Zhang Yudan , Fu Xiaolong , Zhang Xiaoju , Du Lutao , Gu Wei , Wang Xiangdong , Yin Chengqian , Chai Renjie , Chu Bo 
Published: January 2023

AbstractEmerging evidence reveals that amino acid metabolism plays an important role in ferroptotic cell death. The conversion of methionine to cysteine is well known to protect tumour cells from ferroptosis upon cysteine starvation through transamination. However, whether amino acids‐produced metabolites participate in ferroptosis independent of the cysteine pathway is largely unknown. Here, the authors show that the tryptophan metabolites serotonin (5‐HT) and 3‐hydroxyanthranilic acid (3‐HA) remarkably facilitate tumour cells to escape from ferroptosis distinct from cysteine‐mediated ferroptosis inhibition. Mechanistically, both 5‐HT and 3‐HA act as potent radical trapping antioxidants (RTA) to eliminate lipid peroxidation, thereby inhibiting ferroptotic cell death. Monoamine oxidase A (MAOA) markedly abrogates the protective effect of 5‐HT via degrading 5‐HT. Deficiency of MAOA renders cancer cells resistant to ferroptosis upon 5‐HT treatment. Kynureninase (KYNU), which is essential for 3‐HA production, confers cells resistant to ferroptotic cell death, whereas 3‐hydroxyanthranilate 3,4‐dioxygenase (HAAO) significantly blocks 3‐HA mediated ferroptosis inhibition by consuming 3‐HA. In addition, the expression level of HAAO is positively correlated with lipid peroxidation and clinical outcome. Together, the findings demonstrate that tryptophan metabolism works as a new anti‐ferroptotic pathway to promote tumour growth, and targeting this pathway will be a promising therapeutic approach for cancer treatment.
Pencil‐Drawn Generator Built‐in Actuator for Integrated Self‐Powered/Visual Dual‐Mode Sensing Functions and Rewritable Display
Authors: Gu Wansong , Zhou Peidi , Zhang Wei , Luo Zhiling , Chen Luzhuo 
Published: January 2023

AbstractMultifunctionality is important to the development of next‐generation actuators and intelligent robots. However, current multi‐functional actuating systems are achieved based on the integration of diverse functional units with complex design, especially lacking in multi‐mode sensing and displaying functions. Herein, a light‐driven actuator integrated with self‐powered/visual dual‐mode sensing functions and rewritable display function is proposed. The actuator demonstrates a bending curvature of 0.93 cm−1 under near‐infrared light irradiation. Meanwhile, by embedding a pencil‐drawn graphite generator and thermochromic materials, the actuator also provides two independent sensing functions. First, owing to the photo‐thermoelectric effect of graphite, the actuator spontaneously outputs a self‐powered voltage (Seebeck coefficient: 23 µV K−1), which can reflect the deformation trend of actuator. Second, color changes occur on the actuator during deformation, which provide a visual sensing due to the thermochromic property. Furthermore, the actuator can be utilized as a rewritable display, owing to the integrated color‐memorizing component. Intelligent robots, switches, and smart homes are further demonstrated as applications. All of them can spontaneously provide self‐powered and visual sensing signals to demonstrate the working states of actuating systems, accompanied by rewritable displays on the actuators. This study will open a new direction for self‐powered devices, multi‐functional actuators, and intelligent robots.
Self‐Powered Photodetector Based on Perovskite/NiOx Heterostructure for Sensitive Visible Light and X‐Ray Detection
Authors: Tao Kewen , Xiong Chenwei , Lin Jiachun , Ma Decai , Lin Shaopeng , Wang Biao , Li Huashan 
Published: January 2023

AbstractSelf‐powered halide perovskite X‐ray detectors have evoked busting interests because they present outstanding properties such as low power consumption, high sensitivity, and integrability without external power source. Nevertheless, existing self‐powered X‐ray detectors exhibit low sensitivity due to the insufficient charge separation and transport. Herein, a self‐powered photodetector for sensitive X‐ray and photodetection based on single‐crystalline perovskite FAPbBr3/NiOx heterostructure is demonstrated. The built‐in field of FAPbBr3/NiOx heterojunction provides a driving force for separation and transport of photoexcited carriers. Without an external power supply, the photodetector presents excellent photoresponse performance under 450 nm light illumination, including high photoresponsivity (123.6 mA W−1), good detectivity (D = 7.1 × 1011 Jones), and ultrafast response/recovery time (10/200 ns). Simultaneously, the device achieves photovoltaic effect of 0.80 V and a large mobility–lifetime product of 1.1 × 10−3 cm2 V−1, which enable a superior X‐ray sensitivity of 402 µC Gyair−1 cm−2 at zero bias voltage. These results imply that the simple combination of perovskite single crystal and a hole transporting layer provides a flexible platform for the realization of energy‐saving self‐powered photodetector in visible light and X‐rays.