bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy of paclitaxel‐carboplatin with bevacizumab as a late‐line therapy for patients with advanced nonsquamous non‐small cell lung cancer: A platinum rechallenge
Authors: Sugisaka Jun , Toi Yukihiro , Kawashima Yosuke , Domeki Yutaka , Aiba Tomoiki , Kawana Sachiko , Nakamura Atsushi , Yamanda Shinsuke , Kimura Yuichiro , Sugawara Shunichi 
Published: September 2023

AbstractBackgroundThere is no well‐established late‐line treatment for advanced nonsquamous non‐small cell lung cancer (NSCLC). Therefore, we retrospectively determined the efficacy and safety of platinum rechallenge with paclitaxel‐carboplatin and bevacizumab in patients with nonsquamous NSCLC as a late‐line therapy in a clinical setting.MethodsThirty patients with nonsquamous NSCLC who received paclitaxel‐carboplatin with bevacizumab therapy as a late‐line treatment at Sendai Kousei Hospital (Miyagi, Japan) between December 2011 and December 2021 were enrolled into the study. The efficacy and safety of this treatment were evaluated. The patients were further categorized into responders and nonresponders, and predictive factors of treatment response were estimated.ResultsThe median progression‐free survival (PFS) was 6.3 (range, 4.9–6.8) months, and the median overall survival (OS) was 11.8 (range, 7.2–17.2) months. There were no significant differences in PFS and OS between patients with and those without epidermal growth factor receptor mutations. In the univariate analyses of this study, responders were younger than nonresponders (p = 0.012). No fatal adverse events were reported.ConclusionsWith the increase in the number of treatment options in recent years, the sequence of treatments and overall therapeutic strategy are becoming increasingly important. Thus, platinum rechallenge with paclitaxel‐carboplatin and bevacizumab, a late‐line treatment for patients with nonsquamous NSCLC, may be an effective therapeutic option.
Acute versus late endoscopic dacryocystorhinostomy in treatment of acute dacryocystitis: A prospective randomised trial with an 18‐month follow‐up
Authors: Lilja Markus , Leivo Tiina , Uusitalo Marita , Vento Seija , Virkkula Paula , Blomgren Karin 
Published: September 2023

AbstractPurposeTo compare the long‐term symptom resolution and use of resources of performing endoscopic dacryocystorhinostomy (enDCR) in acute or delayed phase in patients with acute dacryocystitis (AD).MethodsThis prospective, randomised controlled trial was conducted in Helsinki University tertiary Eye and Ear, Nose and Throat (ENT) Hospitals between September 2013 and January 2019. Fifty patients aged 18 and above presenting with AD in the emergency care were randomised into acute and delayed enDCR surgery groups, performed in 1 week or 4 months from the diagnosis of AD. The follow‐up time was 18 months. Outcome measures were subjective epiphora, lacrimal symptoms and visual analogue scale (VAS) pain scores, the number of hospitalised and unhealthy days, use of medication and openness in lacrimal syringing and dye test.ResultsEnDCR was performed on 24 patients in the acute and 19 in the delayed group. There were no significant differences between the groups in follow‐up lacrimal symptoms, syringing test, dye test or use of resources. At the 18 months' follow‐up, 21/23 (91.3%) in the acute group and 12/13 (92.3%) in the delayed group had no disturbing lacrimal symptoms. When reoperations and dropouts are considered, beneficial outcome was 22/24 (91.7%) in the acute and 12/16 (75%) (p = 0.195) in the delayed group. The acute group had significantly fewer pain medication days than the delayed group, 3 versus 10.5 (p = 0.03).ConclusionAcute enDCR is associated with fewer pain medication days and equal resolution of lacrimal symptoms and use of resources.
Letter: Safety after cessation of nucleos(t)ide analogue therapy in patients with chronic hepatitis B infection
Authors: Liu Yen‐Chun , Jeng Wen‐Juei , Chien Rong‐Nan 
Published: September 2023

LINKED CONTENTThis article is linked to Hsu et al papers. To view these articles, visit https://doi.org/10.1111/apt.17614 and https://doi.org/10.1111/apt.17681
Editorial: Unveiling new horizons for liver steatosis genetic variants beyond hepatocellular carcinoma diagnosis ‐ exploring the potential of HSD17B13 inhibition
Authors: Valenti Luca , Casirati Elia 
Published: September 2023

LINKED CONTENTThis article is linked to Innes et al paper. To view this article, visit https://doi.org/10.1111/apt.17638
Waitlist and post‐transplant outcomes among candidates listed for liver transplant: Liver alone versus simultaneous liver kidney listings
Authors: Singal Ashwani K. , Kuo Yong‐Fang 
Published: September 2023

SummaryBackgroundData comparing waitlist and post‐transplant outcomes of liver transplantation (LT) alone (LTA) versus simultaneous liver kidney (SLK) listings are limited.AimTo examine 90‐days waitlist and 1‐year post‐transplant outcomes of LT listings since Organ Procurement Transplant Network (OPTN) policy for SLK, who had cirrhosis with eGFR <30 mL/min or on dialysis at listing.MethodsAdults (08/2017–03/2021) with first LT listing (2628 SLK) were stratified on renal function from listing: acute kidney injury (AKI): rise of serum creatinine by ≥0.3 mg/dL or <42 days hemodialysis; chronic kidney disease (CKD): eGFR <60 mL/min for ≥90 days or ≥42 days hemodialysis.ResultsAmong 7094 adults analyzed, 90‐days competing cumulative waitlist mortality was 18.2% in LTA + CKD (n = 37), 15.3% in LTA + AKI (n = 3337), 15% in SLK + AKI (n = 2070), and 11% in SLK + CKD (n = 403), p < 0.001. On fine and gray model, compared to SLK + CKD, LTA + AKI had 1.4–fold waitlist mortality. On a median post‐transplant follow up of 1 year, patient survival was similar comparing LTA versus SLK for AKI (89% each, p = 0.83), for CKD (93 vs. 86%, p = 0.55), but lower in recipients listed for SLK with no AKI or CKD (93 vs. 88%, p = 0.02), adjusted hazard ratio (95% CI) of 0.7 (0.4–1.2). Among 1024 LTA recipients without AKI or CKD from listing, 117 were listed for SLK, and their 1‐year survival was poorer compared to LT alone listings (79 vs. 95%, p < 0.002, adjusted HR 3.6 (1.3–10.3); p = 0.015).ConclusionsAmong candidates with renal dysfunction at listing for LT, those listed for LT alone should receive transplant promptly to optimise waitlist outcomes. Those listed for SLK should wait to receive both organs to optimise post‐transplant outcomes.
A UK national survey of enteral feed use in people with diabetes 2022
Authors: Flanagan Daniel , Lake Andrea K. , Green Mark , Roberts Aled , Dhatariya Ketan ,   the Joint British Diabetes Societies for Inpatient Care
Published: September 2023

AbstractAimsEnteral feeding is commonly used to manage a variety of medical conditions in hospitals. For people with diabetes this can present a specific challenge for glucose management. To address gaps in our understanding of modern enteral feeding outcomes and to help with the development of more specific guidance on maintaining glycaemic control, we conducted a national survey on the management of enteral feeding against the standards in the nationally adopted Joint British Diabetes Societies for Inpatient Care (JBDS) guidelines.MethodsA questionnaire was developed using the 2018 JBDS guideline as a template this questionnaire was sent out by email to all 220 UK specialist diabetes teams. Databases of Diabetes UK, the Association of British Diabetologists (ABCD) and the Diabetes Inpatient Specialist Nurse UK Group were used.ResultsTwenty‐six hospitals responded, 11 had guidelines for the management of insulin with enteral feeding. There were three main feed regimens used: continuous 24‐h feeding, a single feed with one break in 24 h, or multiple feeds in 24 h. There were five regimens in common use: premixed insulin, isophane insulin, analogue basal insulin, variable rate intravenous insulin or basal bolus insulin. Overall glucose control was poor for all regimens and combinations. Continuous feed showed better glucose control than a single feed with a break, mean (±SD) glucose 12.4 mmol/L (5.6) versus 15.1 mmol/L (6.9) p < 0.005, but no group showed optimal control.ConclusionsManaging diabetes control during enteral feeding remains a challenge. Our survey showed that glucose control during this treatment is suboptimal.
Intra‐articular triamcinolone acetonide injection results in increases in systemic insulin and glucose concentrations in horses without insulin dysregulation
Authors: Boger Brooke L. , Manfredi Jane M. , Loucks Abigail R. , Salamey Maya Z. , Kapeller Lydia E. , Fricano Allie G. , Winkler Ani , Yob Chelsey , Colbath Aimee C. 
Published: September 2023

AbstractBackgroundCorticosteroids are a commonly used, inexpensive intra‐articular treatment for osteoarthritis which may increase the risk for laminitis in horses due, in part, to hyperinsulinaemia. Humans with metabolic syndrome experience increases in insulin and glucose concentrations post‐injection, but responses in horses are unknown.ObjectivesTo determine the effect of a single intra‐articular (IA) dose of triamcinolone acetate (TA) on blood insulin and glucose concentrations.Study designBefore‐after study.MethodsTen horses with normal insulin regulation as assessed by an oral sugar test received 18 mg of TA into one middle carpal joint. Insulin and glucose concentrations were evaluated at baseline and 4, 6, 8, 24, 48, and 72 h following IA corticosteroid injection. Differences from baseline were evaluated using a repeated measures ANOVA with Dunnett's multiple comparison testing or a Friedman test with Dunn's correction (significant at p < 0.05).ResultsMean ± SD blood insulin concentration post IA TA injection was increased at 6 h (15.8 ± 3.1 μIU/mL, p = 0.01), 24 h (23 ± 5.8 μIU/mL, p ≤ 0.001), and 48 h (29 ± 13 μIU/mL, p ≤ 0.01) compared to baseline (10 ± 12.3 μIU/mL), with the peak at 48 h. Median ± 95% CI blood glucose concentration post IA TA injection was increased at 6 h (112.7 ± 20.3 mg/dL, p = 0.006), 8 h (112.9 ± 21.4 mg/dL, p = 0.004), 24 h (122.6 ± 14.6, p ≤ 0.0001), and 48 h (123.5 ± 15.4 mg/dL, p ≤ 0.0001) compared to baseline (89.2 ± 6.6 mg/dL), with the peak at 48 h.Main limitationsOnly horses with normal insulin regulation were evaluated.ConclusionsBlood insulin and glucose concentrations modestly increased for 48 h following IA TA.
Funding Strategies in a Rising Interest Rate and a Flattening Yield Curve Environment
Authors: Abuaf Niso 
Published: September 2023

The author suggests that an optimal corporate funding strategy may be a “barbell” that combines short‐term borrowings (to exploit still low short‐term rates) with some long‐term borrowing to lock in historically low interest rates against the possibility of rising inflation and interest rates. Abuaf shows that a “barbell” funding strategy is on the “efficient frontier” of corporate liability structure, i.e., the curve tracing the lowest cost and lowest standard deviation points. Such strategies consist of a barbell with occasional medium‐term borrowings, but with some “rollover” or funding risk attached.Once the efficient frontier has been delineated, the chief financial officer can use breakeven analysis to choose the optimal maturity mix. The choice between fixed and floating interest rates will depend upon management's tolerance for earnings fluctuations resulting from moves in shortterm rates.While most of the existing literature predicts that a lot of short‐term debt leads to early default, Abuaf sees that an upward sloping yield curve can easily make shortterm debt cheaper than longterm although it comes at the cost of higher volatility. It follows that in a flatter yield curve environment, longer maturities may be more attractive. If a company's revenues are highly correlated with short‐term rates, it should keep maturities relatively short, however.If, as Abuaf thinks most likely, that interest rates increase 100 basis points across the curve, CFOs should lengthen maturities now.
Financing Urban Revitalization: A Pro‐Growth Template
Authors: Hanke Steve H. , Walters Stephen J.K. 
Published: September 2023

The co‐authors recommend American cities adopt a particular property‐tax rate cutting strategy. They contrast relatively prosperous San Francisco with impoverished Baltimore. Both cities actually raised property taxes frequently between 1950 and 1975 with roughly the same results–falling population and rising crime. During the same period, many other cities also raised tax rates to make up for lower economic output, thereby encouraging more people and businesses to leave.The change in San Francisco's economic fortunes did not arise out of either a successful crime‐fighting program (it had worse crime than Baltimore in 1975) or through the rising prosperity of Silicon Valley forty miles to its south (still too small and far away to make a difference). Rather, the inflection point for San Francisco was in 1978 when a statewide referendum (“Proposition 13”) limited property taxes to 1% of assessed value. San Francisco's revenue declined by 18% the next year, 1979, but by 1982, its revenue was 66% higher than before Prop 13, despite the lower rates.Prop 13 improved cash flows to owners of real property in San Francisco and protected their property rights. Investors bought, built, and improved the city's residential and commercial capital stock, attracting new residents and creating new job opportunitiesPoliticians are reluctant to try to adopt Prop 13‐like measures on their own, however, because the short‐term consequences for politicians are painful as several years are required for underlying economic activity to grow enough to offset rate cuts.The key is to build a financial bridge before crossing the river through four‐steps:1. Announce a property tax rate cap that is immediately binding but which would take effect over several years in the future. Rational investors would immediately begin to invest and expand the city's tax base.2. During the transition period, the city should limit its spending to a “maintenance of service” level, while allocating any added revenue to an escrow fund.3. The city should supplement this reserve with the proceeds of sales of assets on its balance sheet via sale‐and‐leaseback contracts (SLBs).4. If revenue falls in the short run, cash would be withdrawn from the escrow fund in order to continue to maintain levels of government services at accustomed levels.
Effect of coffee thermocycling on the surface roughness and stainability of denture base materials with different chemical compositions manufactured with additive and subtractive technologies
Authors: Çakmak Gülce , Weber Franziska Alexandra , Donmez Mustafa Borga , Kahveci Çiğdem , Schimmel Martin , Yilmaz Burak 
Published: September 2023

AbstractObjectiveTo evaluate the effect of coffee thermocycling (CTC) on the surface roughness (Ra) and stainability of denture base materials with different chemical compositions fabricated by using additive and subtractive manufacturing.Materials and MethodsDisk‐shaped specimens were additively (FREEPRINT denture, AM) or subtractively (G‐CAM, GSM and M‐PM, SM) fabricated from three pink denture base materials in different chemical compositions (n = 10). Ra was measured before and after polishing, while color coordinates were measured after polishing. Specimens were subjected to CTC (5000 cycles) and measurements were repeated. Color differences (ΔE00) after CTC were calculated. Ra among different time intervals within materials was evaluated by using repeated measures analysis of variance (ANOVA), while 1‐way ANOVA was used to evaluate the Ra of different materials within each time interval and the ΔE00 values. Color coordinates within each material were compared by using paired samples t‐tests (α = 0.05).ResultsRa before polishing was the highest for all materials (p < 0.001), while SM had its lowest Ra after CTC and AM had its lowest Ra after polishing (p ≤ 0.008). Before polishing, AM had the highest Ra among the materials (p < 0.001). After polishing, SM had higher Ra than AM (p < 0.001). After CTC, GSM had the lowest Ra (p ≤ 0.048). SM had the lowest (p ≤ 0.031) and AM had the highest (p < 0.001) ΔE00. CTC decreased the a* and b* values of SM and AM (p ≤ 0.017), and increased the L* values of AM (p < 0.001).ConclusionsPolishing significantly reduced the surface roughness of all materials. CTC did not increase the surface roughness of materials above the clinically acceptable threshold. Only AM had perceptible color change when previously reported threshold values for denture base materials were considered.Clinical SignificanceTested denture base materials may have similar surface stability after coffee thermocycling. However, subtractively manufactured denture base materials may have improved color stability when subjected to long‐term coffee consumption.
Transdermal patches: Do they really works?—A comparative study of ketoprofen versus diclofenac analgesic patches in minor oral surgery
Authors: Kalita Flora , Gehlot Neelima , Gupta D. S. , Mitra Subhajit 
Published: September 2023

AbstractAim and objectivesA prospective split mouth study was done to compare the efficacy of transdermal ketoprofen versus diclofenac patch after therapeutic orthodontic tooth extraction based on four parameters – pain intensity (VAS), number of rescue analgesia intakes, local allergic reactions and patient tolerability for immediate and 3 consecutive postoperative days.Materials and methodsIn total, 33 (66 extraction sites) patients were divided into the ketoprofen patch group and the diclofenac patch group. A single ketoprofen patch (70 cm2 30 mg) was applied following extraction of premolars of the 1st and 4th quadrants and patients were recalled after 1 week for extractions of premolars of the 2nd and 3rd quadrants and diclofenac patch (50 cm2 100 mg) was applied on the deltoid region of the right arm, respectively. Patients were then evaluated under the above‐mentioned parameters.ResultsKetoprofen transdermal patch was found to be more effective in terms of controlling postoperative pain and the minimum number of rescue analgesia tablets taken as compared to diclofenac (statistically significant on 1st and 2nd day) though the former showed the incidence of a local allergic reaction (p‐value 0.002, 0.002 and 0.012), respectively, in few cases which were not seen in case of diclofenac.ConclusionOverall, both the transdermal patches are effective in terms of safety and providing analgesia, though more research are needed in proving the safeness and efficiency of these transdermal patches with large sample size.
Women–state relations: The gendered politics of social protection provisioning in Zambia
Authors: Pruce Kate 
Published: September 2023

AbstractDespite clear gendered differences in rights and responsibilities, these variations within citizen‐state relations are often overlooked. Drawing on Ranjita Mohanty's concept of women–state relations and Nancy Fraser's trivalent theory of social justice, this paper asks how access to social assistance is shaped by gender. Analysing the processes of policy design and implementation of Zambia's social cash transfer scheme, the paper examines perceptions of roles and responsibilities in the private domain and claims to state assistance in the public sphere. Based on 77 key informant interviews with institutional stakeholders, and 16 focus group discussions with cash transfer (non‐)beneficiaries, the research finds a predominant belief that ‘able‐bodied’ men and women should be working but dramatically different expectations of women and men in the household. The paper argues that social policies can be rights‐determining rather than rights‐based, demonstrated by the changes to Zambia's targeting model based on perceived responsibilities, with material consequences for citizens and particularly women.
Effectiveness of mHealth interventions for improving health attendance: an umbrella review protocol
Authors: Kumar Sadhna , Kuchewar Vaishali , Karuveettil Vineetha 
Published: September 2023

Objective:
The objective of this umbrella review is to assess the effectiveness of mobile health (mHealth) interventions for improving health care attendance.

Introduction:
Health attendance is a critical part of health service delivery and is considered a behavior influenced by personal characteristics, service availability, nature of the treatment and consultation, and social determinants. Various interventions are available to foster good health attendance behavior, and mHealth interventions are one of the common go-to solutions; however, there is ambiguity regarding their effectiveness.

Inclusion criteria:
Systematic reviews, with or without meta-analysis, that specifically examine the impact of mHealth interventions on health care attendance will be considered. The review will not be restricted to any particular disease, health problem, stream, or system of care, nor will it be limited by population characteristics (eg, age, gender, socio-economic status) or context (setting can be at any level of care).

Methods:
The JBI methodology for umbrella reviews will be followed, and MEDLINE (Ovid), Scopus, CINAHL, Cochrane Central, and JBI Evidence Synthesis will be searched for sources of evidence. Unpublished and gray literature sources, such as ProQuest Dissertations and Theses, OAIster, and Google Scholar, will also be searched. The review will be limited to English-language articles published from the inception of the databases to the present. Two independent reviewers will perform title, abstract, and full-text screening, while a customized data extraction form will be used for data extraction. The JBI critical appraisal checklist for systematic reviews and research syntheses will be applied. Certainty of evidence for health attendance outcomes will be assessed following GRADE approach.

Review registration:
PROSPERO CRD42023405677
High-throughput functional trait testing for bacterial pathogens
Authors: Stromberg Zachary R. , Phillips Shelby M. B. , Omberg Kristin M. , Hess Becky M. 
Published: September 2023

ABSTRACT
Functional traits are characteristics that affect the fitness and metabolic function of a microorganism. There is growing interest in using high-throughput methods to characterize bacterial pathogens based on functional virulence traits. Traditional methods that phenotype a single organism for a single virulence trait can be time consuming and labor intensive. Alternatively, machine learning of whole-genome sequences (WGS) has shown some success in predicting virulence. However, relying solely on WGS can miss functional traits, particularly for organisms lacking classical virulence factors. We propose that high-throughput assays for functional virulence trait identification should become a prominent method of characterizing bacterial pathogens on a population scale. This work is critical as we move from compiling lists of bacterial species associated with disease to pathogen-agnostic approaches capable of detecting novel microbes. We discuss six key areas of functional trait testing and how advancing high-throughput methods could provide a greater understanding of pathogens.