bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mutation of the clock gene timeless disturbs diapause induction and adult emergence rhythm in Helicoverpa armigera
Authors: Liu Xiaoming , Cai Limei , Zhu Lin , Tian Zhiqiang , Shen Zhongjian , Cheng Jie , Zhang Songdou , Li Zhen , Liu Xiaoxia 
Published: January 2023

AbstractBackgroundCircadian rhythms are physical and behavioral changes that follow the 24‐h cycle of Earth's light and temperature and are regulated by clock genes. Timeless (Tim) has been identified as a canonical clock gene in some insects, however, its functions have been little studied in lepidopteran pests.ResultsTo investigate Tim (HaTim) gene function in Helicoverpa armigera, an important lepidopteran pest, we obtained the HaTim mutant using the CRISPR/Cas9 gene editing system. Our results showed that the transcript levels of HaTim rhythmically peaked at night in heads of the wild larvae and adult, and the diel expression of HaTim was sensitive to photoperiod and temperature. The expression rhythms of other clock genes, such as HaPer, HaCry1, HaCry2 and HaCwo, were disturbed in the HaTim mutant larvae, as that stage is a sensitivity period for diapause induction. Fifth‐instar wild‐type larvae could be induced to pupate in diapause under a short‐day photoperiod and low temperature, however, fifth‐instar HaTim mutant larvae could not be induced under the same conditions. In addition, the emergence of wild‐type adults peaked early at night, but the rhythm was disturbed in the HaTim mutant with arrhythmic expression of some clock genes, such as HaPer, HaCry1 and HaCwo in adults.ConclusionOur results suggest that the clock gene Tim is involved in diapause induction and adult emergence in H. armigera, and is a potential target gene for controlling pest. © 2023 Society of Chemical Industry.
Transcriptome analysis indicates the involvement of herbicide‐responsive and plant–pathogen interaction pathways in the development of resistance to ACCase inhibitors in Apera spica‐venti
Authors: Wrzesińska‐Krupa Barbara , Szmatoła Tomasz , Praczyk Tadeusz , Obrępalska‐Stęplowska Aleksandra 
Published: January 2023

AbstractBackgroundThe continuous use of the herbicides contributes to the emergence of the resistant populations of numerous weed species that are tolerant to multiple herbicides with different modes of action (multiple resistance) which is provided by non‐target‐site resistance mechanisms. In this study, we addressed the question of rapid acquisition of herbicide resistance to pinoxaden (acetyl CoA carboxylase inhibitor) in Apera spica‐venti, which endangers winter cereal crops and has high adaptation capabilities to inhabit many rural locations. To this end, de novo transcriptome of Apera spica‐venti was assembled and RNA‐sequencing analysis of plants resistant and susceptible to pinoxaden treated with this herbicide was performed.ResultsThe obtained data showed that the prime candidate genes responsible for herbicide resistance were those encoding 3‐ketoacyl‐CoA synthase 12‐like, UDP‐glycosyltransferases (UGT) including UGT75K6, UGT75E2, UGT83A1‐like, and glutathione S‐transferases (GSTs) such as GSTU1 and GSTU6. Also, such highly accelerated herbicide resistance emergence may result from the enhanced constitutive expression of a wide range of genes involved in detoxification already before herbicide treatment and may also influence response to biotic stresses, which was assumed by the detection of expression changes in genes encoding defence‐related proteins, including receptor kinase‐like Xa21. Moreover, alterations in the expression of genes associated with methylation in non‐treated herbicide‐resistant populations were identified.ConclusionThe obtained results indicated genes that may be involved in herbicide resistance. Moreover, they provide valuable insight into the possible effect of resistance on the weed interaction with the other stresses by indicating pathways associated with both abiotic and biotic stresses. © 2023 Society of Chemical Industry.
Surface modifications of biodegradable AZ31 alloy after immersion in physiological solution
Authors: Ambrogi V. , Bolli E. , Ceccarelli M. , Kaciulis S. , Mezzi A. , Montanari R. , Pakhomova E. , Richetta M. , Varone A. 
Published: January 2023

Internal prosthesis and grafts are currently made of Ti alloys, stainless steels and Co–Cr alloys. In spite of excellent biocompatibility, they show some drawbacks that concern their mechanical properties (e.g. elastic modulus) and the need of secondary surgery for removing the implant. For this reason, a growing attention has been focused on biodegradable materials that can be absorbed into the body after tissue remodelling. In particular, Mg alloys are promising candidates for temporary implants thanks to their high biocompatibility, biodegradability and good mechanical properties that match those of human bone. In this work, the surface modifications of biodegradable AZ31 alloy were analysed after immersion for 15 days in a physiological solution (NaCl 0.09%) by using X‐ray photoelectron spectroscopy (XPS), X‐ray diffraction (XRD) and scanning electron microscopy (SEM) techniques. XPS analysis of the surface of as‐supplied AZ31 alloy showed the presence of MgO, whereas after immersion in the physiological solution, only Mg (OH)2 was detected. The result has been discussed with reference to literature data. From the photoemission spectra and quantitative analysis, a small amount of Ca (about 2 wt%) was also detected.
Sol‐Gel‐Derived Ordered Mesoporous High Entropy Spinel Ferrites and Assessment of Their Photoelectrochemical and Electrocatalytic Water Splitting Performance
Authors: Einert Marcus , Waheed Arslan , Lauterbach Stefan , Mellin Maximilian , Rohnke Marcus , Wagner Lysander Q. , Gallenberger Julia , Tian Chuanmu , Smarsly Bernd M. , Jaegermann Wolfram , Hess Franziska , Schlaad Helmut , Hofmann Jan P. 
Published: January 2023

AbstractThe novel material class of high entropy oxides with their unique and unexpected physicochemical properties is a candidate for energy applications. Herein, it is reported for the first time about the physico‐ and (photo‐) electrochemical properties of ordered mesoporous (CoNiCuZnMg)Fe2O4 thin films synthesized by a soft‐templating and dip‐coating approach. The A‐site high entropy ferrites (HEF) are composed of periodically ordered mesopores building a highly accessible inorganic nanoarchitecture with large specific surface areas. The mesoporous spinel HEF thin films are found to be phase‐pure and crack‐free on the meso‐ and macroscale. The formation of the spinel structure hosting six distinct cations is verified by X‐ray‐based characterization techniques. Photoelectron spectroscopy gives insight into the chemical state of the implemented transition metals supporting the structural characterization data. Applied as photoanode for photoelectrochemical water splitting, the HEFs are photostable over several hours but show only low photoconductivity owing to fast surface recombination, as evidenced by intensity‐modulated photocurrent spectroscopy. When applied as oxygen evolution reaction electrocatalyst, the HEF thin films possess overpotentials of 420 mV at 10 mA cm−2 in 1 m KOH. The results imply that the increase of the compositional disorder enhances the electronic transport properties, which are beneficial for both energy applications.
Equity analysis of an augmented reality‐mediated group activity in a college biochemistry classroom
Authors: Wang Song , Sung Rou‐Jia , Reinholz Daniel L. , Bussey Thomas J. 
Published: January 2023

AbstractThe use of two‐dimensional images to teach students about three‐dimensional molecules continues to be a prevalent issue in many classrooms. As affordable visualization technologies continue to advance, there has been an increasing interest to utilize novel technology, such as augmented reality (AR), in the development of molecular visualization tools. Existing evaluations of these visual–spatial learning tools focus primarily on student performance and attitude, with little attention toward potential inequity in student participation. Our study adds to the current literature on introducing molecular visualization technology in biochemistry classrooms by examining the potential inequity in a group activity mediated by AR technology. Adapting the participatory equity framework to our specific context, we view equity and inequity in terms of access to the technological conversational floor, a social space created when people enter technology‐mediated joint endeavors. We explore three questions: What are the different ways students interact with an AR model of the potassium channel? What are salient patterns of participation that may signify inequity in classroom technology use? What is the interplay between group social dynamics and the introduction of AR technology in the context of a technology‐mediated group activity? Pairing qualitative analysis with quantitative metrics, our mixed‐methods approach produced a complex story of student participation in an AR‐mediated group activity. The patterns of student participation showed that equity and inequity in an AR‐mediated biochemistry group learning activity are fluid and multifaceted. It was observed that students who gave more explanations during group discussion also had more interactions with the AR model (i.e., they had greater access to the technological conversational floor), and their opinion of the AR model may have greater influence on how their group engage with the AR model. This study provides more nuanced ways of conceptualizing equity and inequity in biochemistry learning settings.
Celestial chiral algebras, colour-kinematics duality and integrability
Authors: Monteiro Ricardo 
Published: January 2023

Abstract
We study celestial chiral algebras appearing in celestial holography, using the light-cone gauge formulation of self-dual Yang-Mills theory and self-dual gravity, and explore also a deformation of the latter. The recently discussed w1+∞ algebra in self-dual gravity arises from the soft expansion of an area-preserving diffeomorphism algebra, which plays the role of the kinematic algebra in the colour-kinematics duality and the double copy relation between the self-dual theories. The W1+∞ deformation of w1+∞ arises from a Moyal deformation of self-dual gravity. This theory is interpreted as a constrained chiral higher-spin gravity, where the field is a tower of higher-spin components fully constrained by the graviton component. In all these theories, the chiral structure of the operator-product expansion exhibits the colour-kinematics duality: the implicit ‘left algebra’ is the self-dual kinematic algebra, while the ‘right algebra’ provides the structure constants of the operator-product expansion, ensuring its associativity at tree level. In a scattering amplitudes version of the Ward conjecture, the left algebra ensures the classical integrability of this type of theories. In particular, it enforces the vanishing of the tree-level amplitudes via the double copy.
Pure supersymmetric AdS and the Swampland
Authors: Montero Miguel , Roček Martin , Vafa Cumrun 
Published: January 2023

Abstract
We point out that pure supergravity theories in AdS with enough supersymmetry lead, upon taking the large radius limit, to flat space quantum gravities with a nonperturbatively exact global symmetry, and are therefore in the Swampland. The argument applies to any AdS supergravity with gauged R-symmetry group, including truncations of most well known examples, such as AdS5 without the S5 or AdS4 without the S7. This demonstrates that extreme scale separation, at least with enough supersymmetry, is not realizable. Moreover pure AdS theories are also in conflict with some other Swampland principles including the Weak Gravity Conjecture and the (generalized) Distance Conjecture.
Single inclusive hadron production in DIS at small x: next to leading order corrections
Authors: Bergabo Filip , Jalilian-Marian Jamal 
Published: January 2023

Abstract
We calculate the one-loop corrections to single inclusive hadron production in Deep Inelastic Scattering (DIS) at small x in the forward rapidity region using the Color Glass Condensate formalism. We show that the divergent parts of the next to leading order (NLO) corrections either cancel among each other or lead to x (rapidity) evolution of the leading order (LO) dipole cross section according to the JIMWLK evolution equation and DGLAP evolution of the parton-hadron fragmentation function. The remaining finite parts constitute the NLO (αs) corrections to the LO single inclusive hadron production cross section in DIS at small x.
Probing new physics in the vector-like lepton model by lepton electric dipole moments
Authors: Hamaguchi Koichi , Nagata Natsumi , Osaki Genta , Tseng Shih-Yen 
Published: January 2023

Abstract
We examine the lepton dipole moments in an extension of the Standard Model (SM), which contains vector-like leptons that couple only to the second-generation SM leptons. The model naturally leads to sizable contributions to the muon g − 2 and the muon electric dipole moment (EDM). One feature of this model is that a sizable electron EDM is also induced at the two-loop level due to the existence of new vector-like leptons in the loops. We find parameter regions that can explain the muon g − 2 anomaly and are also consistent with the experimental constraints coming from the electron EDM and the Higgs decay h → μ+μ−. The generated EDMs can be as large as $$ \mathcal{O} $$
O
(10−22)e∙cm for the muon and $$ \mathcal{O} $$
O
(10−30)e∙cm for the electron, respectively, which can be probed in future experiments for the EDM measurements.
Global, Non-Scattering Solutions to the Energy Critical Wave Maps Equation
Authors: Pillai Mohandas 
Published: January 2023

AbstractWe consider the 1-equivariant energy critical wave maps problem with two-sphere target. Using a method based on matched asymptotic expansions, we construct infinite time relaxation, blow-up, and intermediate types of solutions that have topological degree one. More precisely, for a symbol class of admissible, time-dependent length scales, we construct solutions which can be decomposed as a ground state harmonic map (soliton) re-scaled by an admissible length scale, plus radiation, and small corrections which vanish (in a suitable sense) as time approaches infinity. Our class of admissible length scales includes positive and negative powers of t, with exponents sufficiently small in absolute value. In addition, we obtain solutions with soliton length scale undergoing damped or undamped oscillations in a bounded set, or undergoing unbounded oscillations, for all sufficiently large t.
Exploring the potential of combining IL-2-activated NK cells with an anti-PDL1 monoclonal antibody to target multiple myeloma-associated macrophages
Authors: Ehlers Femke A. I. , Mahaweni Niken M. , van de Waterweg Berends Annet , Saya Thara , Bos Gerard M. J. , Wieten Lotte 
Published: January 2023

AbstractMultiple myeloma (MM) is an incurable disease, characterized by malignant plasma cells in the bone marrow. MM growth is largely dependent on the tumor microenvironment (TME), consisting of complex cellular networks that shape a tumor-permissive environment. Within the TME, tumor-associated cells (TAC) comprise heterogeneous cell populations that collectively support immunosuppression. Reshaping the TME toward an immunostimulatory environment may enhance effectiveness of immunotherapies. Here, we investigated interactions between donor-derived natural killer (NK) cells and TAC, like tumor-associated macrophages (TAM) and M1 macrophages, and assessed whether anti-tumor effector functions of NK cells could be enhanced by an ADCC-triggering antibody targeting macrophages. Monocytes were polarized in vitro toward either M1 or TAM before co-culture with high-dose IL-2-activated NK cells. NK cell responses were assessed by measuring degranulation (CD107a) and IFN-γ production. We found that NK cells degranulated and produced IFN-γ upon interaction with both macrophage types. NK cell responses against PD-L1+ M1 macrophages could be further enhanced by Avelumab, an anti-PD-L1- and ADCC-inducing antibody. Additionally, NK cell responses were influenced by HLA class I, shown by stronger degranulation in NK cell subsets for which the corresponding HLA ligand was absent on the macrophage target cells (KIR-ligand mismatch) compared to degranulation in the presence of the HLA ligand (KIR-ligand match). Our results suggest that NK cells could, next to killing tumor cells, get activated upon interaction with TAC, like M1 macrophages and TAMs, and that NK cells combined with PD-L1 blocking antibodies with ADCC potential could, through IFN-γ secretion, promote a more immune-favorable TME.
Using deep learning to predict survival outcome in non-surgical cervical cancer patients based on pathological images
Authors: Zhang Kun , Sun Kui , Zhang Caiyi , Ren Kang , Li Chao , Shen Lin , Jing Di 
Published: January 2023

Abstract
Purpose
We analyzed clinical features and the representative HE-stained pathologic images to predict 5-year overall survival via the deep-learning approach in cervical cancer patients in order to assist oncologists in designing the optimal treatment strategies.

Methods
The research retrospectively collected 238 non-surgical cervical cancer patients treated with radiochemotherapy from 2014 to 2017. These patients were randomly divided into the training set (n = 165) and test set (n = 73). Then, we extract deep features after segmenting the HE-stained image into patches of size 224 × 224. A Lasso–Cox model was constructed with clinical data to predict 5-year OS. C-index evaluated this model performance with 95% CI, calibration curve, and ROC.

Results
Based on multivariate analysis, 2 of 11 clinical characteristics (C-index 0.68) and 2 of 2048 pathomic features (C-index 0.74) and clinical–pathomic model (C-index 0.83) of nomograms predict 5-year survival in the training set, respectively. In test set, compared with the pathomic and clinical characteristics used alone, the clinical–pathomic model had an AUC of 0.750 (95% CI 0.540–0.959), the clinical predictor model had an AUC of 0.729 (95% CI 0.551–0.909), and the pathomic model AUC was 0.703 (95% CI 0.487–0.919). Based on appropriate nomogram scores, we divided patients into high-risk and low-risk groups, and Kaplan–Meier survival probability curves for both groups showed statistical differences.

Conclusion
We built a clinical–pathomic model to predict 5-year OS in non-surgical cervical cancer patients, which may be a promising method to improve the precision of personalized therapy.
A model of transmissivity and hydraulic conductivity from electrical resistivity distribution derived from airborne electromagnetic surveys of the Mississippi River Valley Alluvial Aquifer, Midwest USA
Authors: Ikard Scott J. , Minsley Burke J. , Rigby James R. , Kress Wade H. 
Published: January 2023

AbstractGroundwater-flow models require the spatial distribution of the hydraulic conductivity parameter. One approach to defining this spatial distribution in groundwater-flow model grids is to map the electrical resistivity distribution by airborne electromagnetic (AEM) survey and establish a petrophysical relation between mean resistivity calculated as a nonlinear function of the resistivity layering and thicknesses of the layers and aquifer transmissivity compiled from historical aquifer tests completed within the AEM survey area. The petrophysical relation is used to transform AEM resistivity to transmissivity and to hydraulic conductivity over areas where the saturated thickness of the aquifer is known. The US Geological Survey applied this approach to a gain better understanding of the aquifer properties of the Mississippi River Valley alluvial aquifer. Alluvial-aquifer transmissivity data, compiled from 160 historical aquifer tests in the Mississippi Alluvial Plain (MAP), were correlated to mean resistivity calculated from 16,816 line-kilometers (km) of inverted resistivity soundings produced from a frequency-domain AEM survey of 95,000 km2 of the MAP. Correlated data were used to define petrophysical relations between transmissivity and mean resistivity by omitting from the correlations the aquifer-test and AEM sounding data that were separated by distances greater than 1 km and manually calibrating the relation coefficients to slug-test data. The petrophysical relation yielding the minimum residual error between simulated and slug-test data was applied to 2,364 line-km of AEM soundings in the 1,000-km2 Shellmound (Mississippi) study area to calculate hydraulic property distributions of the alluvial aquifer for use in future groundwater-flow models.
Climate processes and drivers in the Pacific and global warming: a review for informing Pacific planning agencies
Authors: Chand Savin , Power Scott , Walsh Kevin , Holbrook Neil , McInnes Kathleen , Tory Kevin , Ramsay Hamish , Hoeke Ron , Kiem Anthony S. 
Published: January 2023

Abstract
Pacific Island countries are vulnerable to climate variability and change. Developing strategies for adaptation and planning processes in the Pacific requires new knowledge and updated information on climate science. In this paper, we review key climatic processes and drivers that operate in the Pacific, how they may change in the future and what the impact of these changes might be. In particular, our emphasis is on the two major atmospheric circulation patterns, namely the Hadley and Walker circulations. We also examine climatic features such as the South Pacific Convergence Zone and Intertropical Convergence Zone, as well as factors that modulate natural climate variability on different timescales. It is anticipated that our review of the main climate processes and drivers that operate in the Pacific, as well as how these processes and drivers are likely to change in the future under anthropogenic global warming, can help relevant national agencies (such as Meteorological Services and National Disaster Management Offices) clearly communicate new information to sector-specific stakeholders and the wider community through awareness raising.
Bare and Constructional Compositionality
Authors: Gil David 
Published: January 2023

AbstractThis paper proposes a typology of compositionality as manifest in human language and animal communication. At the heart of the typology is a distinction between bare compositionality, in which the meaning of a complex expression is determined solely by the meanings of its constituents, and constructional compositionality, in which the meaning of a complex expression is determined by the meanings of its constituents and also by various aspects of its structure. Bare and constructional compositionality may be observed in human language as well as in various animal communication systems, including primates and birds. Architecturally, bare compositionality provides the foundations for constructional compositionality, while phylogenetically, bare compositionality is a potential starting point for the evolution of constructional compositionality in animal communication and human language.