bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cost-effectiveness of two reduced pressure compression systems in treating newly diagnosed venous leg ulcers
Authors: Guest Julian F , Fuller Graham W 
Published: June 2023

Objective: To assess the clinical outcomes and cost-effectiveness of using two different reduced pressure compression systems in treating newly diagnosed venous leg ulcers (VLUs) in clinical practice, from the perspective of the UK's National Health Service (NHS). Methods: This was a modelling study based on a retrospective cohort analysis of the case records of patients with a newly diagnosed VLU, randomly extracted from The Health Improvement Network (THIN) database, who were initially treated with a two-layer cohesive compression bandage (TLCCB Lite; Coban 2 Lite, 3M, US) or a two-layer compression system (TLCS Reduced; Ktwo Reduced, Urgo, France). No significant differences were detected between the groups. Nevertheless, analysis of covariance (ANCOVA) was performed to enable differences in patients' outcomes between the groups to be adjusted for any heterogeneity in baseline covariates. Clinical outcomes and cost-effectiveness of the alternative compression systems were estimated over 12 months after starting treatment. Results: Time from wound onset to starting compression was a mean of two months. The probability of healing at 12 months was 0.59 in the TLCCB Lite group and 0.53 in the TLCS Reduced group. Patients in the TLCCB Lite group experienced a marginally better health-related quality of life (HRQoL) of 0.02 quality-adjusted life years (QALYs) per patient compared to those in the TLCS Reduced group. The 12-month NHS wound management cost was £3883 per patient treated with TLCCB Lite and £4235 per patient treated with TLCS Reduced. When the analysis was repeated without ANCOVA, the findings from the base case analysis remained unchanged (i.e., use of TLCCB Lite improved outcomes at lower cost). Conclusion: Within the study's limitations, treating newly diagnosed VLUs with TLCCB Lite instead of TLCS Reduced potentially affords a cost-effective use of NHS-funded resources in clinical practice, since it is expected to result in an increased healing rate, better HRQoL and a lower NHS wound management cost.
Efficacy of drug treatment for severe melioidosis and eradication treatment of melioidosis: A systematic review and network meta-analysis
Authors: Anothaisintawee Thunyarat , Harncharoenkul Krit , Poramathikul Kamonporn , Phontham Kittijarankon , Boonyarangka Parat , Kuntawunginn Worachet , Spring Michele , Boudreaux Daniel , Livezey Jeffrey , Chantratita Narisara 
Published: June 2023

Background
This systematic review and network meta-analysis (NMA) aimed to compare the efficacy of all available treatments for severe melioidosis in decreasing hospital mortality and to identify eradication therapies with low disease recurrence rates and minimal risk of adverse drug events (AEs).

Methodology
Relevant randomized controlled trials (RCT) were searched from Medline and Scopus databases from their inception until July 31, 2022. RCTs that compared the efficacy between treatment regimens for severe melioidosis or eradication therapy of melioidosis, measured outcomes of in-hospital mortality, disease recurrence, drug discontinuation, or AEs, were included for review. A two-stage NMA with the surface under the cumulative ranking curve (SUCRA) was used to estimate the comparative efficacy of treatment regimens.

Principal findings
Fourteen RCTs were included in the review. Ceftazidime plus granulocyte colony-stimulating factor (G-CSF), ceftazidime plus trimethoprim-sulfamethoxazole (TMP-SMX), and cefoperazone-sulbactam plus TMP-SMX had a lower mortality rate than other treatments and were ranked as the top three most appropriate treatments for severe melioidosis with the SUCRA of 79.7%, 66.6%, and 55.7%, respectively. However, these results were not statistically significant. For eradication therapy, treatment with doxycycline monotherapy for 20 weeks was associated with a significantly higher risk of disease recurrence than regimens containing TMP-SMX (i.e.,TMP-SMX for 20 weeks, TMP-SMX plus doxycycline plus chloramphenicol for more than 12 weeks, and TMP-SMX plus doxycycline for more than 12 weeks). According to the SUCRA, TMP-SMX for 20 weeks was ranked as the most efficacious eradication treatment (87.7%) with the lowest chance of drug discontinuation (86.4%), while TMP-SMX for 12 weeks had the lowest risk of AEs (95.6%).

Conclusion
Our results found a non-significant benefit of ceftazidime plus G-CSF and ceftazidime plus TMP-SMX over other treatments for severe melioidosis. TMP-SMX for 20 weeks was associated with a lower recurrence rate and minimal risk of adverse drug events compared to other eradication treatments. However, the validity of our NMA may be compromised by the limited number of included studies and discrepancies in certain study parameters. Thus, additional well-designed RCTs are needed to improve the therapy of melioidosis.
Acute and adaptive cardiovascular and metabolic effects of passive heat therapy or high‐intensity interval training in patients with severe lower‐limb osteoarthritis
Authors: Roxburgh Brendon H. , Campbell Holly A. , Cotter James D. , Reymann Ulla , Williams Michael J. A. , Gwynne‐Jones David , Thomas Kate N. 
Published: June 2023

AbstractExercise is painful and difficult to perform for patients with severe lower‐limb osteoarthritis; consequently, reduced physical activity contributes to increased cardiometabolic disease risk. The aim of this study was to characterize the acute and adaptive cardiovascular and metabolic effects of two low or no impact therapies in patients with severe lower‐limb osteoarthritis: passive heat therapy (Heat) and high‐intensity interval training (HIIT) utilizing primarily the unaffected limbs, compared to a control intervention of home‐based exercise (Home). Participants completed up to 12 weeks of either Heat (20–30 min immersed in 40°C water followed by ~15‐min light resistance exercise), HIIT (6–8 × 60‐s intervals on a cross‐trainer or arm ergometer at ~90–100% peak O2) or Home (~15‐min light resistance exercise); all 3 sessions/week. Reductions in systolic (12 & 10 mm Hg), diastolic (7 & 4 mm Hg), and mean arterial (8 & 6 mm Hg) blood pressure (BP) were observed following one bout of Heat or HIIT exposure, lasting for the duration of the 20‐min monitoring period. Across the interventions (i.e., 12 weeks), resting systolic BP and diastolic BP decreased with Heat (−9 & ‐4 mm Hg; p < 0.001) and HIIT (−7 & ‐3 mm Hg; p ≤ 0.011), but not Home (0 & 0 mm Hg; p ≥ 0.785). The systolic and diastolic BP responses to an acute exposure of Heat or HIIT in the first intervention session were moderately correlated with adaptive responses across the intervention (r ≥ 0.54, p ≤ 0.005). Neither intervention improved indices of glycemic control (p = 0.310). In summary, both Heat and HIIT induced potent immediate and adaptive hypotensive effects, and the acute response was moderately predictive of the long‐term response.
Grid integration of wind farms and the interconnection requirements for the U.S. grid
Authors: Ghadiali Farangmeher , Xydis George 
Published: June 2023

Abstract
The integration of wind turbines and wind farms into the power grid presents significant challenges, including the variable and uncertain nature of wind power, the need for efficient transmission and distribution of power, and the need for advanced control and monitoring systems. Recent advances in wind turbine and wind farm technology have greatly improved their ability to integrate into the power grid. This includes the use of variable speed generators and power electronics, such as inverters, which allow for more accurate control of the power output and better alignment with the grid’s frequency. Additionally, advanced control algorithms, such as model predictive control and feedback linearization, have been developed to improve the stability and reliability of wind power systems. Communication systems have also been integrated into wind power systems to allow for real-time monitoring and control of the wind farm’s performance. This improves the ability of the wind farm to provide ancillary services, such as frequency regulation and voltage control. In this work, the major interconnection requirements for the U.S. grid for the expected mass integration of wind farms were discussed focusing on sustainable and reliable control strategies. The paper explores various control schemes that are used for providing response for grid reliability and sustainability. The analysis also included the future steps that OEMs of wind turbines need to take and the regulatory framework that is needed for ancillary services to provide an equitable platform for all generating units – conventional and renewables.
Vitamin C supplementation modulates crude oil contaminated water induced gravid uterine impaired contractile mechanism and foetal outcomes in Wistar rats
Authors: Salami Shakiru Ademola , Oreagba Fatai. O. , Salahdeen Hussein M. , Olatunji-Bello Ibiyemi I. , Murtala Babatunde A. 
Published: June 2023

Abstract

Objectives
Crude oil is a common environmental contaminant that impacts the reproductive functions of women. Understanding the contractile mechanism of the gravid uterus and how it impacts fetal outcomes during crude oil-contaminated water (CCW) exposure is still evolving. This study investigates the effect of vitamin C supplementation during the ingestion of CCW from Bayelsa, Nigeria, on the contractile mechanism of the gravid uterus and fetal outcomes.

Methods
Fifteen nulliparous pregnant rats were randomly divided into 3 groups of 5 rats each and treated with normal saline (control), CCW (2.5 mL), and CCW + vitamin C (10 mg/kg bwt), respectively. Treatments were via oral gavage from gestation days 1–19. Gas chromatography-mass spectrometry of CCW, uterine oxidative biomarkers, and in vitro contractile activity of excised uterine tissue to acetylcholine, oxytocin, magnesium, and potassium were determined. Furthermore, uterine responses to acetylcholine after incubation with nifedipine, indomethacin, and N-nitro-L-arginine methyl ester were also recorded using the Ugo Basile data capsule acquisition system. Fetal weights, morphometric indices, and anogenital distance were also determined.

Results
Acetylcholine, oxytocin, magnesium, diclofenac, and indomethacin-mediated contractile mechanisms were significantly impaired with CCW exposure; however, vitamin C supplementation significantly attenuated the impaired uterine contractile activity. Maternal serum estrogen, weight, uterine superoxide dismutase, fetal weight, and anogenital distance were significantly reduced in the CCW group compared to the vitamin C supplemented group.

Conclusions
Ingestion of CCW impaired the uterine contractile mechanism, fetal developmental indices, oxidative biomarkers, and estrogen. Vitamin C supplementation modulated these by elevating uterine antioxidant enzymes and reducing free radicals.
lncRNA OIP5-AS1 attenuates the osteoarthritis progression in IL-1β-stimulated chondrocytes
Authors: Zhang Xuefeng , Wang Zhikun , Wang Binbin , Li Jingyi , Yuan Hui 
Published: June 2023

Abstract
In view of the association between long noncoding RNA OIP5-AS1 and osteoarthritis (OA) pathology, the corresponding potential mechanism is worthy of exploration. Primary chondrocytes were identified by morphological observation and immunohistochemical staining of collagen II. The association between OIP5-AS1 and miR-338-3p was analyzed by StarBase and dual-luciferase reporter assay. After the expression of OIP5-AS1 or miR-338-3p in interleukin (IL)-1β-stimulated primary chondrocytes and CHON-001 cells was manipulated, cell viability, proliferation, apoptosis rate, apoptosis-related protein (cleaved caspase-9, Bax) expressions, extracellular matrix (ECM) (matrix metalloproteinase (MMP)-3, MMP-13, aggrecan, and collagen II), PI3K/AKT pathway, and mRNA expressions of inflammatory factors (IL-6 and IL-8), OIP5-AS1, and miR-338-3p were determined by cell counting kit-8, EdU, flow cytometry, Western blot, and quantitative reverse transcription-polymerase chain reaction. As a result, the expression of OIP5-AS1 was downregulated in IL-1β-activated chondrocytes, while miR-338-3p was overexpressed. OIP5-AS1 overexpression reversed the effects of IL-1β on viability, proliferation, apoptosis, ECM degradation, and inflammation in chondrocytes. However, OIP5-AS1 knockdown exhibited opposite effects. Interestingly, the effects of OIP5-AS1 overexpression were partially offset by miR-338-3p overexpression. Furthermore, OIP5-AS1 overexpression blocked the PI3K/AKT pathway by modulating miR-338-3p expression. In sum, OIP5-AS1 promotes viability and proliferation, and inhibits apoptosis and ECM degradation in IL-1β-activated chondrocytes by targeting miR-338-3p through blocking the PI3K/AKT pathway, indicating an attractive strategy for OA treatment.
Visual and thermal camouflage on different terrestrial environments based on electrochromism
Authors: Jeon Suwan , Lee Su Eon , Kim Wonjoong , Lee Sun Hee , Min Seokhwan , Seon Seung Won , Han Seung Ho , Kim Bong Hoon , Lee Heon , Shin Jonghwa 
Published: June 2023

Abstract
Hiding terrestrial objects from aerial monitoring has long been an important objective in national security and public safety. However, the diversity of terrestrial environments raises great challenges to traditional camouflages optimized for a single spectral band or single type of background environment, rendering them vulnerable in other bands or backgrounds. Herein, we experimentally demonstrate simultaneous visual and thermal camouflage that can adapt to two different environments based on a thermally emissive electrochromic layer. We first explore diverse possible theoretical solutions for dual-band dual-environmental camouflage by solving analytic constraints for camouflage and steady-state thermal conditions and select the most viable approach. Based on the theoretical analysis, we design active camouflage thin-film material systems that can approximate two different target visible and infrared signatures of backgrounds under proper bias voltage. Our potentially flexible camouflage surfaces can also conceal heat sources such as human body as well with tailored designs. These results provide new directions in multi-band stealth designs.
Machine learning for the classification of macroscale fracture surfaces
Authors: Herges A. , Ulrich L. , Scholl S. , Müller M. , Britz D. , Mücklich F. 
Published: June 2023

Abstract
The characterization of fractographic surfaces typically requires experts to evaluate the characteristics of fracture surfaces. However, these evaluations are influenced by human factors, such as subjectivity, and suffer from a lack of reproducibility. In this context, machine learning (ML), which has been established in various disciplines within materials science over the past few years, is a promising field enabling a more objective and reproducible evaluation. This study will evaluate the use of ML for the evaluation of fracture surfaces of notched Charpy specimens based on digital camera images. Image sections of the two reference regions “upper shelf” (ductile) and “lower shelf” (brittle) will serve as the database. In a first step, data visualization will be performed and data separability will be verified using unsupervised ML. On this basis, supervised ML will be used to train models to distinguish brittle and ductile fractures. These models will then be applied to determine ductile und brittle portions in mixed fracture modes, with the results being in good agreement with the expert consensus achieved in the round robin test.
Earlier Bedtime and Its Effect on Adolescent Sleep Duration
Authors: Campbell Ian G. , Cruz-Basilio Alejandro , Figueroa Jessica G. , Bottom Vincent B. 
Published: June 2023

BACKGROUND AND OBJECTIVES
Sleep duration decreases by ∼10 minutes per year throughout adolescence. A circadian phase delay and changes in homeostatic sleep regulation enable adolescents to stay up later. We determine if teens are able to increase sleep duration by advancing bedtime and whether this ability changes with age.

METHODS
A younger cohort of 77 participants ranging in age from 9.9 to 16.2 years were studied annually for 3 years. An older cohort of 67 participants ranging in age from 15.0 to 20.6 years was studied only once. Annually, participants kept each of 3 different time in bed (TIB) schedules (7, 8.5, and 10 hours) for 4 consecutive nights. Participants kept their habitual weekday rise times; TIB was altered by advancing bedtimes. We report polysomnography-measured sleep durations from the fourth night of the TIB schedule.

RESULTS
Despite increases in sleep onset latency and wake after sleep onset, sleep duration increased with TIB as bedtime was advanced. Average (SE) sleep duration increased from 402.8 (1.6) minutes with 7 hours to 470.6 (2.1) minutes with 8.5 hours to 527.5 (3.0) minutes with 10 hours TIB. Sleep duration decreased with age (1.55 [0.48] minutes/year), but the TIB effect on sleep duration did not (TIB by age interaction, P = .42).

CONCLUSIONS
Adolescents can substantially increase sleep duration by advancing bedtime, and this ability does not change between ages 10 and 21 years. Additional research is needed to determine how to translate these findings from experiment-controlled sleep schedules to real-world sleep duration increases.
Vegetações de Telhados Verdes Utilizadas em Diferentes Regiões Climáticas para Mitigar o Escoamento Superficial
Authors: Souza Maiza Gleyce Fernandes de , Barros Camille Zamorano Escanoni de , Soares Willames de Albuquerque 
Published: June 2023

RESUMO
Os alagamentos são os maiores danos causados pela urbanização intensiva, responsável pela alta impermeabilização do solo. Sob esta perspectiva, os telhados verdes são opções viáveis e sustentáveis para evitar a sobrecarga do sistema de drenagem. A vegetação, portanto, deve ser cuidadosamente selecionada para alcançar a melhor eficiência hidrológica, pois é ela o fator mais influente do escoamento. Este trabalho tem como objetivo, por meio de uma Revisão Sistemática de Literatura (RSL) e com o auxílio do Periódicos CAPES e da ferramenta computacional State of the Art through Systematic Review (StArt), analisar artigos publicados dentro da temática de Telhados verdes (TV) utilizados como alternativa para mitigar alagamentos, identificando as espécies que foram utilizadas em cada estudo, correlacionando com o clima local e identificando os gêneros de vegetais mais utilizadas em diferentes países. Observou-se que a vegetação (VG) mais proeminente associada à frequência no TV foi a Sedum sp, encontrada em mais de 50% dos estudos. Não foi possível identificar consistência ou frequência de seleção de VG em climas tropicais e áridos. Constatou-se também que em regiões de clima continental, todos os estudos utilizaram a Sedum para implementar e desenvolver práticas sustentáveis ​​de controle de escoamento em áreas urbanas. Portanto, é necessário entender o desempenho hidrológico da cobertura vegetal sob diferentes condições climáticas. Com relação a locais com climas tropicais e áridos, mais pesquisas são necessárias para determinar os gêneros de VG mais utilizados na região.
PALAVRAS-CHAVE: Escoamento Superficial. Alagamento. Drenagem.
Córrego do Caju: um local de socialidades
Authors: Morais Abelar Santana , Busnardo Filho Antonio 
Published: June 2023

Este trabalho tem por objetivo analisar o espaço urbano que circunda e inclui o córrego do Caju situado no bairro Morada da Serra, na cidade de Cuiabá – Mato Grosso. O tema proposto é uma reflexão necessária sobre os rios, como elementos primordiais para o bem-estar não apenas dos moradores da região, mas de toda a cidade. Atualmente, esse córrego urbano esta poluído, e a vegetação de seu entorno esta mal preservada, e as habitações estão próximas ao leito do rio. Diante dessa realidade, a proposta de revitalização do córrego e de seu entorno, depende da implantação de políticas públicas a fim de resgatar a socialidade daquela população, integrando-a ao processo de recuperação da área com uma ação conjunta entre poder público e moradores, por meio de projetos participativos.
PALAVRAS-CHAVE: Revitalização; projeto participativo; Córrego urbano; Socialidade.
Analisis Evapotranspirasi dengan Menggunakan Metode Thornthwaite, Blaney Criddle, Hargreaves, dan Radiasi
Authors: Wirawan Juanda , Idkham M , Chairani Susi 
Published: June 2023

Abstrak. Penelitian ini bertujuan untuk menganalisis evapotranspirasi dengan menggunakan beberapa metode yaitu metode Thornthwaite, Blaney Criddle, Hargreaves, dan Radiasi. Data klimatologi diambil dari dua stasiun yang berbeda, yaitu BMKG Blang Bintang dan Stasiun Klimatologi Indrapuri, Kab. Aceh Besar. Dari hasil penelitian diperoleh bahwa evapotranspirasi potensial (Eto) menunjukkan Eto yang terdapat pada BMKG Blang Bintang lebih tinggi dari pada Stasiun Klimatologi Indrapuri. Perbedaan hasil perhitungan Eto yang terjadi pada setiap metode dipengaruhi oleh data-data iklim yang dipakai. Nilai evapotranspirasi potensial (Eto)yang tertinggi diperoleh dengan menggunakan metode Thornthwaite dan yang terendah dengan menggunakan metode Radiasi. Suhu, curah hujan, radiasi matahari, kecepatan angin, kelembaban udara, tekanan udara, dan lama penyinaran matahari adalah faktor-faktor yang sangat mempengaruhi proses evapotranspirasi potensial. Beberapa metode yang aplikatif untuk menghitung evapotranspirasi.Abstract. The aim of this research is to analyze the evaporation using several methods, such as: Thornthwaite, Blaney Criddle, Hargreaves, and Radiation. Climatology data were taken from two climatological stations: Board of Meteorological, Climatology, and Geophysics of Blang Bintang and Climatology Station of Indrapuri in Aceh Besar District. The results showed that potential evapotranspiration (Eto) in Blang Bintang was higher than the potential evapotranspiration in Indrapuri. The differences of potential evapotranspiration occurred due to different methods used in the calculation. The highest potential evapotranspiration (Eto) obtained using Thornthwaite method and the lowest potential evapotranspiration (Eto) obtained using Radiation method. Temperature, precipitation, solar radiation, wind speed, moisture, air pressure, and the length of solar radiation were the factors that influenced the process of potential evapotranspiration (Eto). Several applicable methods in calculating the potential evapotranspiration (Eto) in Blang Bintang and Indrapuri were Blaney Criddle, Hargreaves and Radiation methods.