bluuebunny/crossref_metadata_2025_split huggingface dataset:
The many faces of social media in business and economics research: Taking stock of the literature and looking into the future
Authors: Tumasjan Andranik 
Published: June 2023

AbstractSince their inception more than 15 years ago, social media have become a vibrant research topic in business and economics research. This article presents an integrative literature review taking stock of and showing the many faces of social media in extant research. Based onN= 1419 articles published in the leading peer‐reviewed business and economics journals in the years 2008–2022, we identify and describe seven overarching research themes, namely, social media as a: (1) market‐oriented interaction hub, (2) resource‐oriented interaction hub, (3) information market, (4) innovation and business venturing hub, (5) societal challenge, (6) political hub, and (7) data source. Finally, we derive a research agenda to stimulate future research on this increasingly important topic.
The prenatal diagnosis and prognosis of fetal right aortic arch and double aortic arch malformation: A single‐center study
Authors: Yan Yani , Yang Zhenjuan , Li Yuntao , Pei Qiuyan , Zhang Xiaohong , Wang Yan , Yin Xiuju , Zhang Lin , Ren Meihong , Liu Guoli 
Published: June 2023

AbstractAimThis study aimed to characterize the pathological types, diagnosis, chromosomal abnormalities, and postnatal clinical manifestations of right and double aortic arch malformations in fetuses.MethodsIn this retrospective study, all fetuses diagnosed with right or double aortic arch anomalies for whom conventional two‐dimensional echocardiography combined with spatio‐temporal image correlation was performed at our tertiary referral center between December 2012 and December 2021 were included.ResultsIn total, 234 fetuses with aortic arch abnormalities were identified. Forty‐one cases lost to follow‐up. One hundred ninety‐three cases were included in this study. One hundred eighty‐seven cases with right aortic arch. Six cases with double aortic arch. Most cases of right aortic arch with aberrant left subclavian artery (77/101, 76.2%) were isolated lesions, whereas most of those with mirror‐image branching (45/75, 60%) were associated with intracardiac or extracardiac anomalies. Chromosomal abnormalities were screened prenatally in 113 fetuses with right aortic arch, among whom three with aberrant left subclavian artery (3/63, 4.8%) and eight with mirror‐image branching (8/50, 16%) had chromosome anomalies (p < 0.05). Furthermore, three cases had microdeletion 22q11.2 and these were significantly associated with intracardiac malformations.ConclusionsMost cases of isolated right aortic arch do not present with clinical symptoms except isolated left subclavian artery and isolated left brachiocephalic trunk. In addition, the risk of chromosomal abnormalities in patients with isolated right aortic arch is very low. We recommend that pregnant women should be informed of the risks and benefits of undergoing invasive prenatal chromosomal detection.
Imaging signs of temporomandibular joint osteoarthritis in an urban population of 65‐year‐olds: A cone beam computed tomography study
Authors: Ottersen Margareth Kristensen , Larheim Tore A. , Hove Lene Hystad , Arvidsson Linda Z. 
Published: June 2023

AbstractBackgroundSymptoms of osteoarthritis (OA) in the temporomandibular joint (TMJ) may vary and possible causes should be further explored, such as prevalence and characteristics of imaging features.ObjectivesInvestigate prevalence, gender differences and characteristics of imaging signs of TMJ‐OA by cone beam computed tomography (CBCT) in a population‐based sample of 65‐year‐old Oslo citizens.Materials and Methods159 (86 women, 73 men) individuals randomly recruited from a cohort of 460 Oslo citizens were examined with CBCT. The TMJs were categorised as with imaging signs of OA, no OA or indeterminate for OA.ResultsCBCT signs of TMJ‐OA were found in 35% of the 159 participants: 47% of the women and 22% of the men. CBCT signs of TMJ‐OA were unilateral in two‐thirds of the TMJs and characterised by articular surface flattening and condylar osteophytes. In almost all joints with bone erosive findings, bone productive findings were also found. Participants with and without CBCT signs of TMJ‐OA showed no significant difference in TMD pain screener. Fourteen of the 159 participants (9%) had pain‐related TMD and 12 (8%) had been in contact with health care services due to TMD.ConclusionsCBCT signs of TMJ‐OA was common in this study group of 65‐year‐old Oslo citizens, found in every second woman and every fifth man. Articular surface flattening and bone productive changes, in particular condylar osteophytes, were the most frequent imaging features. Despite the high frequency of CBCT signs of TMJ‐OA, few of the participants had pain‐related TMD.
Neural speech tracking shifts from the syllabic to the modulation rate of speech as intelligibility decreases
Authors: Schmidt Fabian , Chen Ya‐Ping , Keitel Anne , Rösch Sebastian , Hannemann Ronny , Serman Maja , Hauswald Anne , Weisz Nathan 
Published: June 2023

AbstractThe most prominent acoustic features in speech are intensity modulations, represented by the amplitude envelope of speech. Synchronization of neural activity with these modulations supports speech comprehension. As the acoustic modulation of speech is related to the production of syllables, investigations of neural speech tracking commonly do not distinguish between lower‐level acoustic (envelope modulation) and higher‐level linguistic (syllable rate) information. Here we manipulated speech intelligibility using noise‐vocoded speech and investigated the spectral dynamics of neural speech processing, across two studies at cortical and subcortical levels of the auditory hierarchy, using magnetoencephalography. Overall, cortical regions mostly track the syllable rate, whereas subcortical regions track the acoustic envelope. Furthermore, with less intelligible speech, tracking of the modulation rate becomes more dominant. Our study highlights the importance of distinguishing between envelope modulation and syllable rate and provides novel possibilities to better understand differences between auditory processing and speech/language processing disorders.
Psychophysiological models of hypovigilance detection: A scoping review
Authors: Marois Alexandre , Kopf Maëlle , Fortin Michelle , Huot‐Lavoie Maxime , Martel Alexandre , Boyd J. Gordon , Gagnon Jean‐François , Archambault Patrick M. 
Published: June 2023

AbstractHypovigilance represents a major contributor to accidents. In operational contexts, the burden of monitoring/managing vigilance often rests on operators. Recent advances in sensing technologies allow for the development of psychophysiology‐based (hypo)vigilance prediction models. Still, these models remain scarcely applied to operational situations and need better understanding. The current scoping review provides a state of knowledge regarding psychophysiological models of hypovigilance detection. Records evaluating vigilance measuring tools with gold standard comparisons and hypovigilance prediction performances were extracted from MEDLINE, PsychInfo, and Inspec. Exclusion criteria comprised aspects related to language, non‐empirical papers, and sleep studies. The Quality Assessment tool for Diagnostic Accuracy Studies (QUADAS) and the Prediction model Risk Of Bias ASsessment Tool (PROBAST) were used for bias evaluation. Twenty‐one records were reviewed. They were mainly characterized by participant selection and analysis biases. Papers predominantly focused on driving and employed several common psychophysiological techniques. Yet, prediction methods and gold standards varied widely. Overall, we outline the main strategies used to assess hypovigilance, their principal limitations, and we discuss applications of these models.
Organizational resilience as a key property of enterprise risk management in response to novel and severe crisis events
Authors: Dahmen Patrick 
Published: June 2023

AbstractThe COVID‐19 pandemic represented a novel risk event. Research on similar past crises identified risk culture and leadership as properties of effective enterprise risk management to enable companies to respond “like a rubber ball” to such events. The focus of this paper is on the question of how enterprise risk management (ERM) can develop such resilience. A comprehensive literature review was undertaken to enrich the ERM framework with insights from organizational resilience theory, resource and dynamic capability theory and system psychodynamic thinking, addressing the human dynamics at play when coping with such a crisis. It was complemented by a global empirical study among C‐level executives in insurance on the management of the COVID‐19 pandemic. Some key insights were identified: a learning culture, a strong system permeability, a clear purpose, strong leadership to ensure alignment and autonomy of teams and a culture of trust, where employees feel safe, but also dare to take courageous steps to benefit from the crisis. While the newly developed organizational resilience framework identifies the key themes, the organizational resilience map provides guidance on how to develop organizational resilience. This paper enables researchers and practitioners to identify key themes to render a company more resilient to unforeseen risk events.
New asymptotic representations of the noncentral t‐distribution
Authors: Gil Amparo , Segura Javier , Temme Nico M. 
Published: June 2023

AbstractNew asymptotic approximations of the noncentral t distribution are given a generalization of the Student's t distribution. Using new integral representations, we give new asymptotic expansions not only for large values of the noncentrality parameter but also for large values of the degrees of freedom parameter. In some cases, we accept more than one large parameter. These results are not only in terms of elementary functions, but also in terms of the complementary error function and the incomplete gamma function. A number of numerical tests demonstrate the performance of the asymptotic approximations.
Macroscopic wave propagation for 2D lattice with random masses
Authors: McGinnis Joshua A. 
Published: June 2023

AbstractWe consider a simple two‐dimensional harmonic lattice with random, independent, and identically distributed masses. Using the methods of stochastic homogenization, we prove that solutions with initial data, which varies slowly relative to the lattice spacing, converge in an appropriate sense to solutions of an effective wave equation. The convergence is strong and almost sure. In addition, the role of the lattice's dimension in the rate of convergence is discussed. The technique combines energy estimates with powerful classical results about sub‐Gaussian random variables.
The effects of social vigilantism and masculine honor beliefs on perceptions of confrontation during the COVID‐19 pandemic
Authors: Schiffer Ashley A. , Wilcox Brooke E. , Jones Tucker L. , Saucier Donald A. 
Published: June 2023

AbstractVarying opinions about the COVID‐19 pandemic inspire different behaviors (e.g., mask‐wearing), and confrontation may result between people with differing viewpoints. Individual differences associated with belief superiority (e.g., Social Vigilantism; SV) and/or pride (e.g., Masculine Honor Beliefs; MHB) likely related to third‐person perceptions of pandemic confrontations. In this study (N = 237; US sample), we used vignettes in a 2 (Mask: Yes/No) × 2(Confrontation Response: Vocal Defense/Walked Away) between‐groups design to examine how SV and MHB predict perceptions of (1) responses to public confrontation about (not) wearing a mask and (2) the person being confronted. In general, mask‐wearing and walking away from confrontation were perceived more positively. Higher SV was associated with more positive perceptions of seemingly morally‐justified responses to confrontation (e.g., walking away when confronted for not wearing a mask, vocally defending oneself when confronted for wearing a mask). Contrarily, higher MHB were associated with more positive perceptions of non‐mask‐wearing. This research provides insight about how individual differences in SV and MHB relate to nuances in pandemic confrontations, and responses to confrontations, about (non)mask‐wearing.
COVID‐19 pandemic's impact on the public's confidence in scientific community: The role of personal contact
Authors: Scheitle Christopher P. , DiGregorio Bernard D. , Corcoran Katie E. , Guthrie Sara K. 
Published: June 2023

AbstractObjectiveThis study considers how having personally tested positive for COVID‐19 or knowing someone who has tested positive for COVID‐19 is associated with an individual's reported change in confidence in the scientific community due to the pandemic.MethodsUsing data generated from a probability sample of U.S. adults, we estimate regression models predicting individuals’ reported change in confidence in the scientific community due to the pandemic.ResultsPolitical affiliation, age, having tested positive for COVID‐19, and knowing someone who tested positive for COVID‐19 are associated with reporting changes in confidence in the scientific community due to the pandemic.ConclusionThese findings suggest that the public's perception of the scientific community's response to the COVID‐19 pandemic is in part shaped by individuals’ personal contact with the virus.
Phylomitogenomics reveals mito‐nuclear concordance in social wasps: The performance of mitochondrial markers and gene order for hymenopteran systematics
Authors: Menezes Rodolpho S. T. , Noll Fernando B. , Aragão Marcos , Hermes Marcel G. , Brady Seán G. 
Published: June 2023

AbstractMitochondrial (mtDNA) genes have served as widely utilised genetic loci for phylogenetic and phylogeographic studies of animals. However, the phylogenetic performance of many mtDNA genes has not been empirically evaluated across lineages within hymenopteran wasps. To address this question, we assembled and analysed mitogenomic data from social wasps, representing the four recognised tribes of Polistinae and all Epiponini genera. Additionally, we evaluated whether mtDNA gene order in Polistinae is congruent with its tribal classification. Using concatenation phylogenetic methods, we show phylogenetic congruence between mitogenomic and nuclear data. Statistically comparing the phylogenetic performance of individual mtDNA genes, we demonstrate that for social wasps the molecular markers COI, 16S, NAD5, and NAD2 perform best, while ATP6, COII, and 12S show the worst results. Finally, we verified that the tRNA cluster close to the noncoding region is a hotspot of genetic rearrangements in Vespidae and can be used as additional information for the systematics of this group. Together, these results indicate that mitogenomes contain robust phylogenetic signal to elucidate the evolutionary history of Vespidae. Moreover, our study identifies the best choice of mtDNA markers for systematic investigations of social wasps.
Virtual medical research mentoring
Authors: Chan Jeffrey Shi Kai , Lau Dawnie Ho Hei , King Emma , Roever Leonardo , Liu Tong , Shum Yuki Ka Ling , Ng Kenrick , Dee Edward Christopher , Ciobanu Ana , Bazoukis George , Mahmoudi Elham , Satti Danish Iltaf , Jeevaratnam Kamalan , Baranchuk Adrian , Tse Gary ,   Cardiovascular Analytics Group
Published: June 2023

AbstractBackgroundMedical research is important for professional advancement, and mentoring is a key means by which students and early‐career doctors can engage in research. Contrasting international research collaborations, research mentoring programmes are often geographically limited. As the COVID‐19 pandemic has led to increased use of online technology for classes and conferences, a virtual, international approach to medical research mentoring may be valuable.ApproachWe hereby describe our experience at the Cardiovascular Analytics Group, a virtual international medical research mentoring group established in 2015. We make use of virtual platforms in multi‐level mentoring with peer mentoring and emphasise active participation, early leadership, an open culture, accessible research support and a distributed research workflow.EvaluationWith 63 active members from 14 different countries, the Group has been successful in training medical students and early‐career medical graduates in academic medicine. Our members have led over 100 peer‐reviewed publications of original research and reviews since 2015, winning 13 research prizes during this time.ImplicationsOur accessible‐distributed model of virtual international medical research collaboration and multi‐level mentoring is viable and efficient and caters to the needs of contemporary healthcare. Others should consider building similar models to improve medical research mentoring globally.
sandwichr: Spatial prediction in R based on spatial stratified heterogeneity
Authors: Lin Yue , Xu Chengdong , Wang Jinfeng 
Published: June 2023

AbstractSpatial prediction is commonly used in social and environmental research to estimate values at unobserved locations using sampling data. However, most existing spatial prediction methods and software packages are based on the assumption of spatial autocorrelation (SAC), which may not apply when spatial dependence is weak or non‐existent. In this article, we develop a modeling framework for spatial prediction based on spatial stratified heterogeneity (SSH), a common feature of geographical variables, as well as an R package called sandwichr that implements this framework. For populations that can be stratified into homogeneous strata, the proposed framework enables the estimation of values for user‐defined reporting units (e.g., administrative units or grid cells) based on the mean of each stratum, even if SAC is weak or absent. The estimated values can be used to create predicted surfaces and mapping. The framework also includes procedures for selecting appropriate stratifications of the populations and assessing prediction uncertainty and model accuracy. The sandwichr package includes functions to implement each step of the framework, allowing users to implement SSH‐based spatial prediction effectively and efficiently. Two case studies are provided to illustrate the effectiveness of the proposed framework and the sandwichr package.
Increased drug concentration and repeated eye drop administration as strategies to optimize topical drug delivery: A fluorophotometric study in healthy dogs
Authors: Page Lauren E. , Kubai Melissa A. , Allbaugh Rachel A. , Bedos Leila , Roy Mackenzie M. , Mochel Jonathan P. , Sebbag Lionel 
Published: June 2023

AbstractObjectivesDetermine tear film kinetics with different fluorescein concentrations and repeated eye drop administration at various time intervals.Animals StudiedSix healthy Beagles.ProceduresSix experiments were conducted on separate days: single eye drop administration (control) or two separate eye drops administered at 30 s, 1, 2, 5, and 10 min intervals. For each experiment, one eye received 0.3% fluorescein solution while the other eye received 1% fluorescein solution, and tear fluid was collected with capillary tubes at 0, 1, 5, 10, 20, 30, 40, 50, 60, 90, 120, and 180 min. Fluorescein concentrations were measured using automated fluorophotometry.ResultsCompared with 0.3% solution, eyes receiving 1% fluorescein solution had significantly higher tear film concentrations (p ≤ .046) and the area‐under‐the‐fluorescein‐time curve was twofold greater (p = .005). Compared with control: (i) Tear film concentrations were significantly higher for up to 20 min when repeating administration 30 s to 5 min after the first drop (p ≤ .006); (ii) The highest increase in area‐under‐the‐curve was obtained with 2 and 5 min intervals for 0.3% (+109%–130%) and 1% solutions (+153%–157%); (iii) The highest increase in median precorneal retention time (defined as tear film concentration < 5% from baseline values) was obtained with 5 min intervals for 0.3% (55 min vs. 15 min in control) and 2–5 min intervals for 1% solutions (50 min vs. 25 min in control).ConclusionsDrug delivery to the ocular surface can be enhanced by using more concentrated formulations and/or by repeating eye drop administration 2–5 min after the first dose.
Aldehyde accumulation in
Mycobacterium tuberculosis
with defective proteasomal degradation results in copper sensitivity
Authors: Limón Gina , Samhadaneh Nora M. , Pironti Alejandro , Darwin K. Heran 
Published: June 2023

ABSTRACT

Mycobacterium tuberculosis
is a major human pathogen and the causative agent of tuberculosis disease.
M. tuberculosis
is able to persist in the face of host-derived antimicrobial molecules nitric oxide (NO) and copper (Cu). However,
M. tuberculosis
with defective proteasome activity is highly sensitive to NO and Cu, making the proteasome an attractive target for drug development. Previous work linked NO susceptibility with the accumulation of
para
-hydroxybenzaldehyde (
p
HBA) in
M. tuberculosis
mutants with defective proteasomal degradation. In this study, we found that
p
HBA accumulation was also responsible for Cu sensitivity in these strains. We showed that exogenous addition of
p
HBA to wild-type
M. tuberculosis
cultures sensitized bacteria to Cu to a degree similar to that of a proteasomal degradation mutant. We determined that
p
HBA reduced the production and function of critical Cu resistance proteins of the
r
egulated
i
n
c
opper
r
epressor (RicR) regulon. Furthermore, we extended these Cu-sensitizing effects to an aldehyde that
M. tuberculosis
may face within the macrophage. Collectively, this study is the first to mechanistically propose how aldehydes can render
M. tuberculosis
susceptible to an existing host defense and could support a broader role for aldehydes in controlling
M. tuberculosis
infections.

IMPORTANCE

M. tuberculosis
is a leading cause of death by a single infectious agent, causing 1.5 million deaths annually. An effective vaccine for
M. tuberculosis
infections is currently lacking, and prior infection does not typically provide robust immunity to subsequent infections. Nonetheless, immunocompetent humans can control
M. tuberculosis
infections for decades. For these reasons, a clear understanding of how mammalian immunity inhibits mycobacterial growth is warranted. In this study, we show aldehydes can increase
M. tuberculosis
susceptibility to copper, an established antibacterial metal used by immune cells to control
M. tuberculosis
and other microbes. Given that activated macrophages produce increased amounts of aldehydes during infection, we propose host-derived aldehydes may help control bacterial infections, making aldehydes a previously unappreciated antimicrobial defense.