bluuebunny/crossref_metadata_2025_split huggingface dataset:
Organising work in neonatal transfer: Optimising place of care for babies born moderately preterm
Authors: Paton Alexis , Cupit Caroline , Armstrong Natalie 
Published: May 2023

AbstractThe organisation of neonatal units into geographically‐based networks that offer different levels of care is intended to ensure babies receive the care they need via transfers between different units. In this article, we explore the significant organisational work required in practice to accomplish such transfers. Conducted within a wider study of optimal place of care for babies born between 27 and 31 weeks’ gestation, we draw on ethnographic work exploring the accomplishment of transfers in this complex care context. We undertook fieldwork in six neonatal units across two networks in England, representing 280 hours of observation and formal interviews with 15 health‐care professionals. Drawing on Strauss et al.’s concept of the social organisation of medicine and Allen’s concept of ‘organising work’, we identify three distinct forms of such work central to the successful accomplishment of a neonatal transfer: (1) ‘matchmaking’, to identify a suitable transfer location; (2) ‘transfer articulation’, to successfully effect the planned transfer; and (3) ‘parent engagement’, to support parents through the transfer process. Our findings build on and extend Strauss et al. and Allen’s work by both highlighting the different forms of ‘organising work’ undertaken in this clinical context and the distribution of such work across different professional groups.
The attitudes of parents of typically developing students towards including students with disabilities in mainstream classrooms in the United Arab Emirates
Authors: Dukmak Samir Jabra , Gharaibeh Mahmoud , Alkhatib Razan Numan , Ijha Mervat Amin 
Published: May 2023

AbstractThis study investigates the attitudes of parents of typically developing students towards teaching students with disabilities in the mainstream classrooms, in relation to various family characteristics. This quantitative research employed a descriptive questionnaire survey to investigate the attitudes of parents of typically developing students towards teaching learners with disabilities in regular classrooms. A total of 419 parents of students from Cycle 1 and 2 classrooms in the United Arab Emirates completed the questionnaire. Parents showed positive attitudes towards teaching students with disabilities in the mainstream classrooms. Respondents who had no schooling were found to express more positive attitudes than those who had a college or university education, as were those with a ‘schooling’ level of education. The results revealed no significant relationship between respondents' attitudes towards inclusion and their gender, age, place of residence or the number of children in the family. The UAE Ministry of Education should recognize the importance of this study's findings when implementing the ministerial resolution regarding the philosophy of educational inclusion in all mainstream schools in the UAE. This can be seen as a measure to improve the quality of life and education of all marginalized students, especially those with disabilities.
Effects of cold storage time on the quality and active probiotics of yogurt fermented by Bifidobacterium lactis and commercial bacteria Danisco
Authors: Xu Xinyue , Cui Huaitian , Xu Jiaxin , Yuan Zhiheng , Li Jun , Yang Lina , Wang Shengnan , Liu He , Zhu Danshi 
Published: May 2023

AbstractIn this study, the commercial bacteria Danisco and Bifidobacterium lactis were used to ferment soy yogurt, and then the quality of yogurt and the number of active probiotics in yogurt during storage were investigated. The results showed that the total number of viable bacteria in soy yogurt increased first and then decreased, but all of them met the standard for the number of viable bacteria in probiotic foods. The content of protein, lipid, and total sugar in soy yogurt decreased gradually with the extension of storage time. The texture, water holding capacity, and rheological properties of soy yogurt were improved within 0–10 days, and there was no significant change after 15 days. However, brightness and whiteness of yogurt were significantly reduced. Based on realizing the reuse of soy whey, this study provided a theoretical basis for the research of the shelf life of soy yogurt.Practical ApplicationThis study developed a soy yogurt with good quality and provided a theoretical basis for the study of the shelf life of soy yogurt. In addition, some technical support was provided for the reuse of soy whey.
Blau syndrome with NOD2 mutation in a 54‐year‐old man: A case report
Authors: Wang Zhiyan , Yang Mingdong , Zhang Qunqun , Zhang Suhua , Sui Haifang , Liu Jiane , Yang Qingrui 
Published: May 2023

AbstractBlau syndrome (BS) is a rare genetic immune disease which commonly presents in childhood. Currently, the miss‐rate of BS diagnosis is very high, and an effective clinical management of BS has not been well established. This case report depicts a 54‐year‐old male Chinese patient presenting with hand malformation, fever, skin rash and joint pain. His diagnosis was ultimately confirmed according to typical medical history and genetic analysis. This case report will further help clinicians to be aware of this rare clinical entity for correct diagnosis and proper treatment.
IgG4‐related disease presenting as severely symptomatic hypercalcemia: A case report and review of literature
Authors: Han Pingyang , Sun Chen , Yan Juzhen 
Published: May 2023

AbstractImmunoglobulin G4‐related disease (IgG4‐RD)‐associated hypercalcemia has rarely been reported. We report a case of IgG4‐RD that presented as severe symptomatic hypercalcemia. A 50‐year‐old woman with a history of sustained bilateral periorbital swelling and proptosis for more than 5 years presented to our hospital complaining of a 3‐day history of significant and progressive nausea, vomiting, loss of appetite, fatigue, and pruritus. She denied a long history of medication. On admission, laboratory tests showed severe hypercalcemia with serum adjusted calcium elevated to 4.34 mmol/L and renal dysfunction with serum creatinine elevated to 206 μmol/L. Urinary calcium excretion was increased. The serum IgG4 subclass was markedly elevated to 22.4 g/L with polyclonal hypergammaglobulinemia. Tests of autoantibodies were all negative. Bone metabolism markers that reflect the activity of osteoblasts and osteoclasts were all significantly elevated. However, the levels of intact parathyroid hormone and 25(OH) vitamin D3 were decreased. B‐ultrasonography showed chronic inflammation of bilateral submandibular glands. Neither bone marrow biopsy nor positron emission tomography – computed tomography examination showed evidence of neoplastic diseases. The patient was treated with intravenous saline infusion, loop diuretics, salmon calcitonin, glucocorticoids, and hemodialysis with a good response.
Hazardous human–wildlife encounters, risk attitudes, and the value of shark nets for coastal recreation
Authors: Börger Tobias , Mmonwa Kolobe , Campbell Danny 
Published: May 2023

AbstractShark incidents are rare and graphic events, and their consequences can influence the behavior of beach users, including bathers, to a great extent. These incidents can be thought of as a fearsome risk that may lead decision makers to overreact or respond with inaction. This paper examines the reaction of recreational beach users, including bathers, to changes in the risk of shark incidents. In addition to valuing recreational visits to Durban Beach, South Africa, we study the reaction of beach visitors to a hypothetical scenario in which protective shark nets, deployed in coastal waters to protect bathers, are to be removed. To examine potential heterogeneity of the treatment effect in a travel cost‐contingent behavior model, we develop a semiparametric multivariate Poisson lognormal (MPLN) model to jointly analyze observed and stated visit counts. Results show that removing protective shark nets at Durban beach would decrease recreational visits by more than 20%. Applying the semiparametric MPLN model we further find that both the value of a recreational visit and the predicted change in visitation rates vary as a function of whether recreationists usually enter the water, whether they have heard of previous shark incidents, and their general risk attitude.
A profile of students in a university‐based distance dementia education program: Implications for policy and practice
Authors: Goldberg Lynette R. , Jang Sun Hee (Sunny) , Nguyen Hoang , Bindoff Aidan , Canty Alison J. 
Published: May 2023

AbstractObjectiveThe online program began in 2012 to support aged care workers without a tertiary education or vocational qualification. This paper documents changes in the student profile since initiation of the program, and how the program may support recommendations of the Royal Commission into Aged Care Quality and Safety and engage other educators, providers and policymakers.MethodsFour hundred and seventy‐one commencing undergraduate students completed a 16‐item online survey in 2017 to document demographics and reasons for study. Categorical associations were assessed with univariate logistic regression in R v3.6.ResultsMost students (71%; 336) were aged between 41 and 60 years but the program now included younger (<41 years) and older (>80 years) people. Unlike the 2012 students, about 41% had tertiary‐level qualifications, and 56% were employed in professional positions, including registered nurse, general practitioner and allied health professional. Professional and practice development was the primary reason for study; significantly so for younger (<41 years) participants in aged and dementia care (χ2 (5) = 18.15, p = 0.003) and for those with previous university experience (χ2 (4) = 22.17, p = 0.001). Older (≥61 years) participants enrolled to gain greater knowledge about dementia (χ2 (4) = 17.60, p = 0.002).ConclusionsUnderstanding the changed student profile guided program refinement to ensure the provision of effective, evidence‐based education in dementia understanding and care. Work now focusses on increasing partnerships with aged care organisations, community and postsecondary training institutions to support a continuum of workforce development options, guided by the recommendations of the Royal Commission.
The transcriptional foundations of interferon‐λ‐mediated endometrial cell to uterine receptivity
Authors: Yao Kezhen , Fang Li , Sun Yu 
Published: May 2023

AbstractProblemInterferon‐λ (IFN‐λ) is a novel non‐redundant regulator that participates in the fetal–maternal immune interaction, including immune regulation, uterine receptivity, cell migration and adhesion, and endometrium apoptosis. However, the exact transcriptional foundation for endometrial signaling of IFN‐λ is not completely understood, and studies regarding IFN‐λ to implantation failure in vivo are limited.Method of studyThe gene expression profile of human endometrial Ishikawa cell line treated with IFN‐λ or IFN‐α (100 ng/mL) for 6 h was analyzed using RNA‐sequencing. Real‐time qPCR, western blotting, and enzyme‐linked immunosorbent assay (ELISA) tests were used to validate these sequencing data. An in vivo IFN‐λ knock‐down mouse pregnancy model was performed, and the phenotype analysis and the intrauterine biomarkers detection were applied with the uterus samples.ResultsHigh levels of messenger RNA (mRNA) were detected for genes previously associated with endometrial receptivity, including LIF, AXL, CRYAB, EPHB2, CCL5, and DDX58, following IFN‐λ treatment. Moreover, the data indicated IFN‐λ reduced pro‐inflammatory gene activity compared with IFN‐α, including members of the ISG, TNF, SP100 and interleukin genes. The in vivo mouse pregnancy model showed that inhibition of intrauterine IFN‐λ results in aberrant epithelial phenotype and significantly decreases the embryo implantation rates and derails normal uterine receptivity.ConclusionsThese findings demonstrate the antagonistic and agonistic roles of IFNs in the endometrial cell, suggesting a selective role of IFN‐λ in endometrial receptivity and immunological tolerance regulation. Moreover, the findings provide valuable insight into potential biomarkers related to endometrial receptivity and facilitate an understanding of the molecular changes observed during infertility treatment and contraception usage.
Sweet treats before sleep disrupt the clock system and increase metabolic risk markers in healthy rats
Authors: Soliz‐Rueda Jorge R. , López‐Fernández‐Sobrino Raúl , Schellekens Harriët , Torres‐Fuentes Cristina , Arola Lluis , Bravo Francisca Isabel , Muguerza Begoña 
Published: May 2023

AbstractAimBiological rhythms are endogenously generated natural cycles that act as pacemakers of different physiological mechanisms and homeostasis in the organism, and whose disruption increases metabolic risk. The circadian rhythm is not only reset by light but it is also regulated by behavioral cues such as timing of food intake. This study investigates whether the chronic consumption of a sweet treat before sleeping can disrupt diurnal rhythmicity and metabolism in healthy rats.MethodsFor this, 32 Fischer rats were administered daily a low dose of sugar (160 mg/kg, equivalent to 2.5 g in humans) as a sweet treat at 8:00 a.m. or 8:00 p.m. (ZT0 and ZT12, respectively) for 4 weeks. To elucidate diurnal rhythmicity of clock gene expression and metabolic parameters, animals were sacrificed at different times, including 1, 7, 13, and 19 h after the last sugar dose (ZT1, ZT7, ZT13, and ZT19).ResultsIncreased body weight gain and higher cardiometabolic risk were observed when sweet treat was administered at the beginning of the resting period. Moreover, central clock and food intake signaling genes varied depending on snack time. Specifically, the hypothalamic expression ofNampt,Bmal1,Rev‐erbα, andCartshowed prominent changes in their diurnal expression pattern, highlighting that sweet treat before bedtime disrupts hypothalamic control of energy homeostasis.ConclusionsThese results show that central clock genes and metabolic effects following a low dose of sugar are strongly time‐dependent, causing higher circadian metabolic disruption when it is consumed at the beginning of the resting period, that is, with the late‐night snack.
Editorial: type 1 diabetes, microscopic colitis and the need to explore the complex mechanisms of this association
Authors: Lucendo Alfredo J. 
Published: May 2023

LINKED CONTENTThis article is linked to Kang et al. papers. To view these articles, visit https://doi.org/10.1111/apt.17473 and https://doi.org/10.1111/apt.17518
Letter: delays to diagnosis of IBD—Challenges requiring a systematic approach
Authors: Lucas Sarah , Chauhan Ayushi , Garg Mayur 
Published: May 2023

LINKED CONTENTThis article is linked to Jayasooriya et al papers. To view these articles, visit https://doi.org/10.1111/apt.17370 and https://doi.org/10.1111/apt.17548
A survey of patient informational preferences when choosing between medical and surgical therapy for ulcerative colitis: a sub‐study from the DISCUSS project
Authors: Lee M. J. , Folan A. M. , Baker D. M. , Blackwell S. , Wootton R. , Robinson K. , Sebastian S. , Brown S. R. , Jones G. L. , Lobo A. J. 
Published: May 2023

AbstractAimPeople living with ulcerative colitis (UC) have two broad treatment avenues, namely medical or surgical therapy. The choice between these can depend on patient preference as well as the receipt of relevant information. The aim of this study was to define the informational needs of patients with UC.MethodA postal survey was designed to capture respondent demographics, treatment experienced within the previous 12 months and informational preferences by rating a long list of items. It was delivered through two hospitals that provide tertiary inflammatory bowel disease services. Descriptive analyses were performed to describe demographics and experiences. Principal component analysis was carried out using a varimax rotation to investigate informational needs.ResultsA total of 101 responses were returned (20.1% response rate). The median age of respondents was 45 years and the median time since diagnosis was 10 years. Control preferences skewed towards shared (42.6%) or patient‐led but clinician‐informed (35.6%). Decision regret was low for the population (median 12.5/100, range 0–100). Key informational needs related to medical therapy were benefits and risks of long‐term therapy, burden of hospital attendance, reproductive health, need for steroid treatment and impact on personal life. For surgery, these were stoma information, effect on daily life, effect on sexual and reproductive health, risks and benefits and disruption of life due to surgery.ConclusionThis study has identified key areas for discussion when counselling patients about treatment decisions around medical therapy and surgery for UC.
Fate tracking reveals differences between Reelin+ hepatic stellate cells (HSCs) and Desmin+HSCs in activation, migration and proliferation
Authors: Chen Ning , Liu Shenghui , Qin Dan , Guan Dian , Chen Yaqing , Hou Chenjiao , Zheng Songyun , Wang Liqiang , Chen Xiangmei , Chen Wei , Zhang Lisheng 
Published: May 2023

AbstractThe activation of hepatic stellate cells (HSCs) is the main cause of liver fibrogenesis in response to different etiologies of chronic liver injuries. HSCs are heterogeneous, but the lack of specific markers to distinguish different HSC subset hinders the development of targeted therapy for liver fibrosis. In this study, we aim to reveal new HSC subsets by cell fate tracking. We constructed a novel ReelinCreERT2 transgenic mouse model to track the fate of cells expressing Reelin and their progeny (Reelin+ cells). And we investigated the property of Reelin+ cells, such as differentiation and proliferation, in hepatotoxic (carbon tetrachloride; CCl4) or cholestatic (bile duct ligation; BDL) liver injury models by immunohistochemistry. Our study revealed that Reelin+ cells were a new HSC subset. In terms of activation, migration, and proliferation, Reelin+ HSCs displayed different properties from Desmin+ HSCs (total HSCs) in cholestatic liver injury model but shared similar properties to total HSCs in hepatotoxic liver injury model. Besides, we did not find evidence that Reelin+ HSCs transdifferentiated into hepatocytes or cholangiocytes through mesenchymal‐epithelial transition (MET). In this study, our genetic cell fate tracking data reveal that ReelinCreERT2‐labelled cells are a new HSC subset, which provides new insights into targeted therapy for liver fibrosis.
Autism spectrum disorder and GABA levels in children with succinic semialdehyde dehydrogenase deficiency
Authors: Tokatly Latzer Itay , Hanson Ellen , Bertoldi Mariarita , García‐Cazorla Àngeles , Tsuboyama Melissa , MacMullin Paul , Rotenberg Alexander , Roullet Jean‐Baptiste , Pearl Phillip L. ,   SSADH Deficiency Investigators Consortium
Published: May 2023

AbstractAimTo elucidate the etiological aspects of autism spectrum disorder (ASD) in succinic semialdehyde dehydrogenase deficiency (SSADHD), related to dysregulation of γ‐aminobutyric acid (GABA) and the imbalance of excitatory and inhibitory neurotransmission.MethodIn this prospective, international study, individuals with SSADHD underwent neuropsychological assessments, as well as biochemical, neurophysiological, and neuroimaging evaluations.ResultsOf the 29 individuals (17 females) enrolled (median age [IQR] 10 years 5 months [5 years 11 months–18 years 1 month]), 16 were diagnosed with ASD. ASD severity significantly increased with age (r = 0.67, p < 0.001) but was inversely correlated with plasma GABA (r = −0.67, p < 0.001) and γ‐hydroxybutyrate levels (r = −0.538, p = 0.004), and resting motor threshold as measured by transcranial magnetic stimulation (r = −0.44, p = 0.03). A discriminative analysis indicated that an age older than 7 years 2 months (p = 0.004) and plasma GABA levels less than 2.47 μM (p = 0.01) are the threshold values beyond which the likelihood of ASD presenting in individuals with SSADHD is increased.InterpretationASD is prevalent but not universal in SSADHD, and it can be predicted by lower levels of plasma GABA and GABA‐related metabolites. ASD severity in SSADHD increases with age and the loss of cortical inhibition. These findings add insight into the pathophysiology of ASD and may facilitate its early diagnosis and intervention in individuals with SSADHD.
Fatigue‐related gait adaptations in children with cerebral palsy
Authors: Oudenhoven Laura M. , Van Der Krogt Marjolein M. , Ettema Sanne , Roeleveld Karin , Brehm Merel A. , Buizer Annemieke I. 
Published: May 2023

AbstractAimTo obtain insights into the effects of fatigue on the kinematics, kinetics, and energy cost of walking (ECoW) in children with cerebral palsy (CP).MethodIn this prospective observational study, 12 children with CP (mean age 12 years 9 months, SD 2 years 7 months; four females, eight males) and 15 typically developing children (mean age 10 years 8 months, SD 2 years 4 months; seven females, eight males) followed a prolonged intensity‐based walking protocol on an instrumented treadmill, combined with gas analysis measurements. The protocol consisted of consecutive stages, including a 6‐minute walking exercise (6MW) at comfortable speed, 2 minutes of moderate‐intensity walking (MIW) (with a heart rate > 70% of its predicted maximal), and 4 minutes walking after MIW. If necessary, the speed and slope were incremented to reach MIW. Outcomes were evaluated at the beginning and end of the 6MW and after MIW.ResultsWith prolonged walking, Gait Profile Scores deteriorated slightly for both groups (p < 0.01). Knee flexion increased during early stance (p = 0.004) and ankle dorsiflexion increased during late stance (p = 0.034) in children with CP only. Negligible effects were found for kinetics. No demonstrable change in ECoW was found in either group (p = 0.195).InterpretationKinematic deviations in children with CP are progressive with prolonged walking. The large variation in adaptations indicates that an individual approach is recommended to investigate the effects of physical fatigue on gait in clinical practice.