bluuebunny/crossref_metadata_2025_split huggingface dataset:
What makes patients with traumatic brain injury seize despite receiving phenytoin prophylaxis?
Authors: Generoso Eugene , Diep Calvin , Hua Carolyn , Radar Elizabeth , Ran Ran , Lee Nathanael J. , Rivera-Lara Lucia 
Published: September 2023

Abstract
Background
Post traumatic seizure (PTS) is a well-known complication of traumatic brain injury (TBI). The objective of this study is to identify risk factors associated with breakthrough early PTS in TBI patients receiving phenytoin prophylaxis.
Methods
This was a single centered retrospective study including adult patients admitted to the intensive care unit, had a TBI, and started on phenytoin for seizure prophylaxis within 24 hours of admission. The primary outcome was the incidence and factors associated with early PTS, defined as a confirmed seizure on a continuous electroencephalogram within 7 days of TBI. Secondary outcomes included the association between early posttraumatic seizures and ICU length of stay, hospital length of stay and in hospital mortality.
Results
A total of 105 patients were included in the final analysis. Patients with early PTS were older (65 vs 48 years old, p = 0.01), had a higher Marshall score (5 vs 2, p = 0.01), were more likely to have a Marshall score > 2 (73% vs 37%, p = 0.01), had more neurosurgeries for hematoma evacuation (57% vs 19%, p = 0.01) and had higher number of neurosurgical procedures (1 vs 0, p = 0.02). In patients with early PTS, 87.5% had a therapeutic level (> 10 mcg/mL) at the time of seizure. Patients with early PTS had a longer ICU length of stay (14.7 days vs 5.9 days, p = 0.04) and a greater proportion of hospital mortality (21% vs 2%, p = 0.02).
Conclusions
Patients with higher age, Marshall score, hematoma evacuation and neurosurgical procedures had higher incidences of breakthrough early PTS despite the use of phenytoin prophylaxis. The majority of patients had therapeutic phenytoin levels at the time of seizure.
3D Metapaper with unprecedented mechanical properties under water
Authors: Zhu Mingwei , Huang Dafang , Liu Jia , Zhang Songyan , Fang Zhiqiang , Niu Shanyuan , Wang Zhenlin , Li Xiaoyan , Zhu Shining , Chen Yanfeng 
Published: September 2023

Abstract
Paper has been one of the most widely used sustainable materials for millennia. It is fascinating that its two-dimensional (2D) microstructure consisting of randomly stacked plant fibers has not significantly changed. Such laminate structure leads to paper’s limited mechanical strength and vulnerability to water. Here, we report a novel Metapaper architecture with unprecedented mechanical properties and a scalable roll-to-roll manufacturing process. The Metapaper consists of paper fibers tightly knitted with each other in three-dimensions (3D). Compared with conventional paper, Metapaper exhibits ultra-high mechanical properties, even in aqueous environments. A wet tensile strength of 11.2 MPa, fracture work of 797 KJ/m3 and abrasion resistance of 708 cycles have been achieved, which is about 16, 56 and 350 times more than that of regular paper, respectively. It can be folded over 600 times when loaded with 250g weight and bent at 135° under wet conditions, whereas regular paper would break down upon any folding operation. Except superior mechanical properties, Metapaper is completely additive-free, fully degradable and retains regular paper’s pleasurable visual and tactile sensations. We also demonstrate continuous roll-to-roll production of 3D Metapaper up to 45 cm in width with minimal add-on cost. The unprecedented mechanical properties of 3D Metapaper and its easily scalable manufacturing processes enable new prospects for paper’s applications.
An Investigation into the Electrical Properties of L- Cysteine Doped Potassium Dihydrogen Phosphate Crystals Grown under Electric Field
Authors: Mahadik Ashwini , Mithani Amol , Soni P. H. 
Published: September 2023

Abstract
Potassium Dihydrogen Phosphate (KDP) is a well-known non-linear optical material and has numerous applications related to electro-optic switching and laser systems. L-Cysteine (C3H7NO2S) doped KDP crystals were grown using the slow evaporation solution growth method. The conventional two-probe method was used to perform impedance spectroscopy in order to study the dielectric behaviour and conduction mechanism between 323 K and 373 K at frequencies between 100 Hz and 1MHz. According to this study, the conductivity of KDP crystals increases with temperature and impurity concentration in the presence of an electric field. The dielectric constant, dielectric loss, complex impedance modulus, alternating current (a. c.) and direct current (d. c.) conductivities of pure and L-Cysteine doped KDP crystals have been measured as functions of frequency, temperature, and doping concentration. It is observed that the conductivity of crystals changes with temperature, indicating that this change is thermally induced. Jonscher’s universal power law has been used to analyze frequency-dependence of ac conductivity. As the temperature increases, the value of ‘s’ decreases, which implies that the a. c. conduction mechanism of crystals follow Correlated Barrier Hopping (CBH) mechanism.
Technological innovation in bioformulation between algae and PGPR to optimize germination and early growth of horticultural species
Authors: Iparraguirre Julia , Llanes Analía , Cortés Julieta , Reynaga Roxana Judith , Masciarelli Oscar , Reginato Mariana Andrea 
Published: September 2023

Abstract
In recent years, the landscape of horticulture has undergone a transformation characterized by a reduction in cultivation area and a simultaneous surge in intensive production. This shift has been driven by the integration of cutting-edge technological innovations, with a notable emphasis on biofertilization techniques aimed at enriching soil nutrients. Within this context, our current study explores the efficiency of a novel biofertilizer originated from the synergy between Macrocystis pyrifera algal extracts and the plant growth–promoting bacterium Azospirillum argentinense. This study is focused on assessing the potential of this biofertilizer to enhance germination and the establishment phase of prevalent horticultural species, including tomato, lettuce, radish, chicory and cabbage. The seeds of the five species were inoculated and placed in germination trays in a growth chamber to evaluate germination and early seedling growth. The results showed a positive effect of the combined use of both biofertilizers on germination in lettuce, radish and chicory, where the co-inoculation produced significant differences. Moreover, early growth parameters were significantly improved in all the horticultural species studied, mainly with the combination of A. argentinense and algal extract. From the results obtained arise that the use of M. pyrifera algal extract is an interesting tool for agriculture that may improve the general plant growth and to provide stress protection. Moreover, a new biofertilizing formula is obtained when A. argentinense is combined with the algal extract, with promising effects on germination and early growth in the horticultural species used in this study.
Usability evaluation of the computerized physician order entry system: A study in a developing country
Authors: Mohammadzadeh Zahra , Nickfarjam Ali Mohammad , Shakri Ali Akbar , Aghasizadeh Fatemeh , Rasooli Zahra , Miranzadeh Yalda 
Published: September 2023

Abstract
Background
Electronic prescribing is one of the most important processes with vital functions in the health system of any country. Electronic prescription is one of the best solutions to overcome many problems of the paper (manual) prescription process, such as writing errors. In this study, our purpose was to evaluate the Iranian computerized physician order entry system (CPOE).
Method
This is a cross-sectional research using a case study method that was conducted in 2023. The statistical population included two groups of physicians and users of outpatient units who were working in three hospitals (Shahid Beheshti, Akhwan, and Matini) under the supervision of Kashan University of Medical Sciences. For user interaction satisfaction the Iranian CPOE system was used from the QUIS Questionnaire. Also, to get a general idea of users' subjective evaluations of the Iranian CPOE system, the System Usability Scale questionnaire (SUS) was used. The data were analyzed using descriptive statistics (average and standard deviation), analytical (Independent-sample t-tests and one-way ANOVA), and calculation formula of the SUS questionnaire through SPSS software.
Result
According to the results obtained from the participants through the QUIS questionnaire, the overall user satisfaction range of the Iranian CPOE system from the physician's point of view was 4.65 out of 9 and from the outpatient unit user's point of view was 5.73 out of 9. Also, based on the results obtained from the participants through the SUS questionnaire, the overall usability score of the computerized physician order entry system was 72 out of 100 from the view of physicians and 76 out of 100 from according to outpatient unit users.
Conclusion
Iran's CPOE system is almost good in overall reactions due to being easy to use and learn, having control level, being stimulating, and being flexible to the needs of users. Also, the SUS questionnaire showed that the computerized physician order entry system was at a good level. Of course, at first glance and according to overall reactions, QUIS questionnaire and scores obtained from the SUS questionnaire Iran CPOE system can be evaluated as good, but they are still lacking and this shows that this Iranian CPOE system can be more competent. Therefore, it is recommended that in updating future versions of the Iranian CPOE system, authorities should pay attention to the demands and needs of its users and use aesthetic elements in design and development according to the principles of human-computer interaction.
Effect of intermittent Pringle maneuver on perioperative outcomes and long- term survival following liver resection in patients with hepatocellular carcinoma
Authors: Hu Lingbo , Wang Aidong , Qiao Yingli , Huang Xiandan 
Published: September 2023

Abstract
Background: Intermittent Pringle maneuver (IPM) is commonly used to control bleeding during liver resection. IPM can cause ischemia-reperfusion injury, which may affect the prognosis of patients with hepatocellular carcinoma (HCC). The present meta-analysis was conducted to evaluate the effect of IPM use on perioperative outcomes and long-term survival in patients with HCC.
Methods: A systemic literature search was performed in the PubMed, Embase, Web of Science, and Cochrane Library databases to identify randomized controlled trials and retrospective studies that compared the effect of IPM with no Pringle maneuver during liver resection in patients with HCC. Hazard ratio (HR), risk ratio, and standardized mean difference, and their 95% confidence interval (CI) values were calculated based on the type of variables.
Results:This meta-analysis included nine studies comprising one RCT and eight retrospective studies and involved a total of 3268 patients. Perioperative outcomes, including operation time, complications, and length of hospital stay, except for blood loss, were comparable between the two groups. After removing the studies that led to heterogeneity, the results showed that IPM was effective in reducing blood loss. Five studies reported overall survival (OS) and disease-free survival (DFS) data and eight studies reported perioperative outcomes. No significant difference in OS and DFS was observed between the two groups (OS: HR, 1.01; 95% CI, 0.85–1.20; p = 0.95; DFS: HR, 1.01; 95% CI, 0.88–1.17; p = 0.86).
Conclusion:IPM is a useful technique to control blood loss during liver resection and does not affect the long-term survival of patients with HCC.
Study on the use of waste polypropylene-based mask in crude oil as viscosity reducer
Authors: Du Yingna , Jing Rui , Li Wenjuan , Li Yongfei , Wu Ya , Chen Gang 
Published: September 2023

Abstract

The COVID-19 leads the use and waste of a large number of polypropylene-based masks, and improper or arbitrary disposal of waste masks will cause serious environmental pollution. In order to utilize waste masks as resources, this work prepared oil soluble crude oil fluidity improvers using waste masks as a raw materials. The effect of the layers and their mixture of masks on reducing crude oil viscosity was evaluated, and then the most effective one was compounded with other oil soluble viscosity reducers and polymers to enhance its impact on the viscosity and pour point of crude oil. The results show that the tri-component, composed of oil PP-2, polyethylene glycol and sodium dodecylbenzene sulfonate (named as CPPA), can reduce the viscosity of crude oil by 72.9%, depress the pour point by 7°C, reflecting excellent functional efficiency. DSC analysis shows that CPPA can reduce the wax precipitation point. CPPA can eutectic with wax crystals in crude oil, resulting in wax crystal disorder, changing intermolecular forces, and changing the crystal form of wax, thereby reducing the pour point. CPPA also interferes with the hydrogen bonds between polycyclic aromatic hydrocarbons and colloidal macromolecules, thereby reducing viscosity. In addition, the viscosity reduction effects of other oil samples from CPPA have also been studied, indicating that CPPA has certain universal applicability, which has explored a feasible path for the resource utilization of waste masks.
Fano Resonance Based Ultra-Sensitive Nano- Displacement Sensor Using All-Dielectric Metamaterials
Authors: Karimipour Mohammad Reza , Naeimi Azadeh Sadat , Javadifar Nader , Nasrollahnejad Mohammad Bagher 
Published: September 2023

Abstract
In this paper, an ultra-sensitive nano-displacement sensing system consisting of an all-dielectric and mechanically tunable metamaterial has been proposed. The proposed sensor takes benefits from highly sensitive Fano resonance peaks as a result of the asymmetrical topology of the metamaterial. Simulation results demonstrate that perfect Fano resonance peaks with ultra-narrow bandwidths are achievable in the reflection spectrum of the proposed metamaterial which can provide excellent sensing characteristics. Based on the simulations performed using the frequency domain solver, a sharp resonance peak of a spectral bandwidth around 0.9 nm can be attained at the wavelength of 651 nm. Furthermore, the optical sensitivity of 1.04 nm/nm obtained for the proposed micro device, to the best of our knowledge, is the highest has ever been reported. The simple fabrication process, high resolution, and relatively highly wide measurement range are among the other features of the proposed micro device which make it suitable for several applications ranging from tunable reflectors to high-accuracy inertial sensors.
DTA-UNet: U-Net Based on Dynamic Convolution Decomposition and Triplet Attention
Authors: Li Yang , Yan Bobo , Hou Jianxin , Bai Bingyang , Huang Xiaoyu , Xu Canfei , Fang Limei 
Published: September 2023

Abstract
Medical image segmentation methods can assist doctors to quantify and diagnose lesions faster, and give more accurate treatment plans. However, in practical clinical applications, the robustness and generalization ability of medical image segmentation models are challenging due to the differences between different disease types, different image types and different cases. Although U-Net is a universal segmentation framework, it still has the problems of limited feature expression and inaccurate segmentation. To this end, we propose DTA-UNet, a U-Net based on Dynamic Convolution Decomposition (DCD) and Triple Attention (TA). The model uses Attention U-Net as the baseline network. Firstly, we use DCD to replace all conventional convolutions in the encoding-decoding process to enhance its feature extraction capabilities. Secondly, we combine TA with Attention Gate (AG) to skip connections, remove redundant information in both spatial dimensions and channel dimensions, and highlight lesion regions. Then, we performed ablation experiments on the stroke segmentation dataset of the cooperative hospital, which proved the effectiveness of DCD and TA, and the parameters (params) were only increased by 0.7628M compared with the baseline algorithm. Finally, to verify the universality of the DTA-UNet, it was applied to the cooperative hospital stroke segmentation dataset, the public COVID-SemiSeg dataset and the ISIC 2018 dataset, and was compared with 6 advanced methods. The experimental results show that DTA-UNet has advantages in different segmentation indexes, can effectively segment different types of lesions, and is more friendly to the boundary blur problem, which is better than other methods.
Vimentin contributes to the comorbidities of Cryptococcus neoformans and HIV-1 gp120
Authors: He Long-Xiao , Zhang Tie-Song , Li Li , Zhang Mu-Jie , Liang Jia-Xin , Zeng Qing , Zhang Bao , Huang Sheng-He , Cao Hong , Peng Liang 
Published: September 2023

Abstract
Cryptococcus neoformans (CN) is the most common pathogen causing fungal meningitis (CNM)in patients with acquired immunodeficiency syndrome (AIDS). Due to the ambiguity of the mechanism of comorbidity of CNM and human immunodeficiency virus (HIV)-1 encephalopathy, AIDS patients with CNM have maintained a high mortality rate. CD44 on the surface of human brain microvascular endothelial cells (HBMECs), which is a main component of the blood–brain barrier (BBB), mediates the CN adhesion and penetration across the BBB. However, the HIV-1 envelope protein gp120, which binds to vimentin (Vim), is required for the entry of virus into the target cells. Our previous study has shown that NF-κB is regulated by Vim that interacts with soluble CD44. How VIM and gp120 contributing to the comorbidity of AIDS-associated CNM remain largely unknown. In this study, we generated a Vim−/−/gp120 double transgenic mouse strain and a meningitis mouse model of CN infection. Compared with Vim+/+/gp120 mice, the number of CN in the brain, circulating brain microvascular endothelial cells (cBMECs) in the blood, and p65 and TNF-α concentrations in the cerebrospinal fluid (CSF) of Vim−/−/gp120 mice were significantly decreased. In addition, astrocyte proliferation and the degree of the neuron/BBB damage induced by CN infection were also reduced in Vim−/−/gp120 mice. In vitro experiments showed that the NF-κB inhibitor caffeic acid phenethyl ester (CAPE), Ca2+-calmodulin inhibitor trifluoperazine (TFP), and the lipid raft inhibitor Nys inhibited gp120-induced leukocyte migration. The VIM inhibitors Withaferin-A (WFA) and ginsenoside Rg3 significantly blocked VIM protein expression and gp120-induced astrocyte proliferation. Our results suggest that VIM is required for the gp120-mediated CN invasion of BBB in AIDS patients, which is closely related to the activation of the NF-κB pathway and the development of meningitis. VIM-targeting inhibitors have the potential to be developed into new drugs for the treatment of CN meningitis in AIDS patients.
YAP/TEAD involvement in resistance to paclitaxel chemotherapy in lung cancer
Authors: Brosseau Solenn , Abreu Paula , Bouchez Clémentine , Charon Lucie , Kieffer Yann , Gentric Géraldine , Picant Valentin , Veith Irina , Camonis Jacques , Descroix Stéphanie , Mechta-Grigoriou Fatima , Parrain Maria-Carla , Zalcman Gérard 
Published: September 2023

Abstract
Background: The Yes-associated protein (YAP) oncoprotein has been linked to both metastasis and resistance to targeted therapy of lung cancer cells. We aimed to investigate the effect of YAP pharmacological inhibition, using YAP/ TEA domain (TEAD) transcription factor interaction inhibitors, in chemo-resistant lung cancer cells.
Methods: YAP subcellular localization, cell migration, and TEAD transcription factor functional transcriptional activity were investigated in cancer cell lines with up-regulated YAP, with and without YAP/TEAD interaction inhibitors. Parental (A549) and paclitaxel-resistant (A549R) cell transcriptomes were analyzed. The half-maximal inhibitory concentration (IC50) of paclitaxel or trametinib, an inhibitor of Mitogen-Activated protein kinase and Erk Kinase (MEK), combined to YAP/TEAD inhibitor (IV#6) was determined. A three-dimensional (3D) microfluidic culture device enabled us to study the effect of IV#6/paclitaxel combination on cancer cells isolated from fresh resected lung cancer samples.
Results: YAP activity was significantly higher in paclitaxel-resistant cell lines. YAP/TEAD inhibitor induced a decreased YAP activity in A549, PC9, and H2052 cells, with reduced YAP nuclear staining. Wound healing assays upon YAP inhibition revealed impaired cell motility of lung cancer A549 and mesothelioma H2052 cells. Combining YAP pharmacological inhibition with trametinib, in A549, K-Ras mutated cells, recaped synthetic lethality, sensitizing these cells (MEK) inhibition. The YAP/TEAD inhibitor lowered paclitaxel IC50 in A549R cells. Differential transcriptomic analysis of parental and A549R cells revealed an increase of YAP/TEAD transcriptomic signature in resistant cells, down-regulated upon YAP inhibition. YAP/TEAD inhibitor enabled restoring paclitaxel sensitivity in A549R cells cultured in a 3D microfluidic system, with lung cancer cells from a fresh tumor efficiently killed by YAP/TEAD inhibitor/paclitaxel doublet.
Conclusions: Evidence on YAP/TEAD transcriptional program's role in resistance to chemotherapy opens routes towards therapeutic YAP targeting.
Prostate radiotherapy may cause fertility issues – a retrospective analysis of testicular dose following modern radiotherapy techniques
Authors: KISSEL Manon , TERLIZZI Mario , GIRAUD Nicolas , ALEXIS Anthony , CHEVE Marjolaine , VAUTIER Julien , BOSSI Alberto , MORICE Philippe , BLANCHARD Pierre 
Published: September 2023

Abstract

Background
Prostate cancer in younger men is not infrequent. Radiotherapy is a cornerstone of prostate cancer treatment and yet, its impact on fertility is scarcely reported in literature. Since testis is one of the most radiosensitive tissue, we tried to determine testicular dose with modern radiotherapy techniques for a definitive prostate irradiation.
Methods
one hundred radiotherapy plans were reviewed. Testicles were contoured a posteriori without any optimization on testicles.
Results
Median testicular dose was 0.58 Gy: 0.18 Gy in stereotactic plans versus 0.62 Gy in Volumetric Modulated Arc Therapy plans versus 1.50 Gy in Tomotherapy plans (p < 0.001). Pelvic nodal irradiation increased the median testicular dose: 1.18 Gy versus 0.26 Gy (p < 0.001). Weight and BMI were inversely associated with testicular dose (p < 0.005). 65% of the patients reached the theoretical dose threshold to get transitory azoospermia and 10% received more than 2 Gy, that is likely to give definitive azoospermia.
Conclusion
although probably lower than what used to be delivered with older techniques, testicular dose delivered with modern prostate radiotherapy is not negligible and is often underestimated because the contribution of daily repositioning imaging is not taken into account and most Treatment Planning Systems underestimate the out of field dose. Radiation oncologists should be aware of the possible impact of prostate radiotherapy on fertility and gonadal endocrine secretion. Men should be counselled at first consult and offered a sperm preservation strategy if they have a paternity wish.
Trial registration
retrospectively registered