bluuebunny/crossref_metadata_2025_split huggingface dataset:
Kinetic Modeling of Co-Gasification of biomass and low-grade coal under flameless conditions ​
Authors: rehman Anees , unar imran nazir , Quershi khadija , abro masroor 
Published: August 2023

Abstract

For more than a century, gasification of coal and biomass has been the only method used to produce gas-liquid fuels and create chemicals. Current work is based on new direction of research in the field of biomass gasification. The main of work is to investigate the characterization of biomass and coal samples for feed to gasification simultaneously. Three different types of biomass utilized in the current study that is based on availability on huge level and easy of handling. The study used a pressurized thermo-gravimetric analyzer (PTGA) and a quartz fixed-bed reactor to investigate the gasification reactions. The quartz fixed-bed reactor was utilized to prepare coal char at 900°C in a nitrogen environment. Dynamic heating segments were employed with a consistent heating rate throughout the experiments. The temperature range for the experiments was from room temperature to 1000°C. The gasification reactions were studied at different pressures: 1 atm., 5 atm., and 10 atm. using pure CO2 and H2O as reacting gases. The gasification reactions of the char samples with CO2 and steam (H2O) as reacting species were observed to initiate at 750°C and were completed after reaching 950°C at atmospheric pressure (1 atm). This means that the char began to react with the gases at 750°C and continued to do so until it reached 950°C, at which point the reactions were considered complete. The weight loss data obtained from the PTGA results were used to analyze the kinetic behavior of Thar lignite char during gasification reactions with CO2 and steam (H2O). The kinetic behavior provides insights into the rate at which the reactions occur and how they are influenced by temperature, pressure, and reacting gases.
The correlation of bioactive components between human female adult peripheral and umbilical cord blood platelet-rich plasma
Authors: Cui Xiao , Li Xiongjie , Ma Yongshi , Mai Zhiming , Yang Yao , Luo Min , Xu Wenping , Chen Kui , Chen Xuri , Tang Jianbing , Cheng Biao , Tian Ju 
Published: August 2023

Abstract
Background: Few studies have reported the components, especially anti-aging related substances of umbilical cord blood-derived platelet-rich plasma( PRP).
Objective: The aim of this study was to compare the concentrations of bioactive components in PRP from healthy female adults and umbilical cord blood-derived PRP.
Methods: Prepare PRP with blood samples from 4 different female age groups (12 in each group): Group A, umbilical cord blood (UCB) of female neonates; Group B: aged 18-25years; Group C: aged 26-45 years; Group D: aged 46-65 years. The concentrations of epidermal growth factor (EGF), basic fibroblast growth factor-2 (FGF-2), insulin-like growth factor-1 (IGF-1), PLT-derived growth factor-AA (PDGF-AA), PLT-derived growth factor-AB/BB (PDGF-AB/BB), vascular endothelial growth factor A (VEGF-A), RANTES, TIMP1, TIMP2, GDF11, Clusterin and activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) in the PRP samples were determined and compared.
Results: There are statistically significant differences in the concentration of anti-aging related bioactive components, FGF-2, PDGF-AB/BB, Clusterin and GPx activity in PRP between different groups.
Conclusion: PRP prepared by UCB contains a variety of active ingredients including anti-aging proteins. Due to its rich source and low immunogenicity, the use of UCB to prepare PRP is an important research direction in the future.
Evolution of heteromorphic XY chromosomes in sea buckthorn via chromosomal fusion followed by inversions and tissue-specific dosage compensation
Authors: Li Yiling , Wang Deyan , Sun Pengchuan , Zhao Jiale , Shan Lanxing , Ru Dafu , Ren Guangpeng , Ma Tao , Renner Susanne S. , Liu Jianquan 
Published: August 2023

Abstract
Recombination suppression is crucial for the evolution of sex chromosomes, but remains poorly understood. Two recent models explaining recombination suppression start with the occurrence of a chance inversion that includes a sex-determining gene and that becomes established either because it shelters recessive deleterious mutations or instead because dosage compensation stabilizes the inversion. We assembled the male and female genomes of the sea buckthorn (Hippophae rhamnoides), a shrub with large X and small Y chromosomes, and compared them to the chromosomes of a relative with bisexual flowers representing the ancestral condition. The sex-determining region of 13-15 Mb is located inside the fusion site of two ancestral chromosomes and coincides with a large inversion, while an adjacent younger stratum includes four inversions, and an even younger stratum two inversions. Using de novo transcriptome data from five tissues, we quantified tissue-specific gene expression and found that dosage compensation is mainly achieved through the upregulation of X-specific genes in males. Few genes with sex-biased expression were found in the three strata. These data fit with models that focus on sequential inversions and dosage compensation and poorly match the classic model of an increasing accumulation of sexually antagonistic genes leading to recombination suppression.
A general model of treeline form and dynamics
Authors: Brown David , Kummel Miroslav , McDevitt Makayla 
Published: August 2023

Abstract

Treeline is a global ecological phenomenon in which tree populations decline, often abruptly, above a specific elevation or latitude. Temperature is thought to be a key determinant of treeline because it affects the rates at which trees establish, grow, produce seeds, and die. As climate change causes temperature increases, treelines have been observed to move in response – but there is considerable variability. In this study we present a general mathematical model that helps to explain both the general patterns observed in treelines and some of the variation. Avoiding system-specific details, our model assumes simply that all life processes are temperature dependent. We incorporate the possibility of positive or negative feedback, in which the presence of trees either increases or decreases the temperature at their location. Our results indicate that this feedback and the relationship between temperature thresholds for growth, seed production, and seedling establishment are the key determinants of tree line form and movement. The model also shows that under many conditions bistability is predicted: treeline can equilibrate at two different elevations under the same conditions, depending on the system’s history. General, flexible models like ours are essential for generating a unifying theory of treeline form and dynamics across multiple ecosystems.
Early-Onset Colorectal Cancer: Prevalence, Risk Factors, and Clinical Features among Commercially Insured Adults in the United States
Authors: Tait Christopher , Patel Ankoor , Chen Alexander , Li You , Minacapelli Carlos , Rustgi Vinod 
Published: August 2023

Abstract
Background
The incidence of colorectal cancer in patients younger than 50 has been rising in the last 30 years, accounting for up to 25% of total cases. Despite the screening age recently being lowered to 45, a significant proportion of cases would still arise at younger ages prior to screening. Nonfamilial early onset colorectal cancer remain a particular concern. Identification of risk factors and clinical features in this age group is needed to improve detection.
Methods
In this retrospective cohort analysis using claims data from the Truven Health MarketScan insurance database from 2007–2017, patients were identified with colon and rectal cancer, compared across three age groups (ages 18–40, 40–50 and > 50), and analyzed for risk factors and clinical features.
Results
Females sex was more prevalent in the younger age group compared to age > 50 (54% and 51.9% vs 49.6%), with little change noted between rectal cancer age groups by sex. A higher percentage of younger patients were in the obese age groups compared with older groups for colon cancer, particularly the morbidly obese with BMI > 40 (24.94%, 25.75%, and 21.34% in the three age groups). Abdominal pain was a common presenting symptom identified in the age groups < 50 compared with age > 50 (25% and 19% vs 14%) along with hematochezia, weight loss, and anemia.
Conclusions
Morbid obesity and female sex may be important risk factors among patients with early onset CRC. The presence of abdominal pain was more common among the early onset CRC cohort.
A Global Invasion Risk Assessment of Spodoptera frugiperda (Lepidoptera: Noctuidae) Under Climatic Change
Authors: Ragab Sanad H. , Tyshenko Michael G. 
Published: August 2023

Abstract
Spodoptera frugiperda, (Lepidoptera: Noctuidae) commonly known as the fall armyworm (FAW), is a serious maize and sorghum pest endemic to North and South America. Recently, the insect has invaded most of Africa, China and the Tropics where it is now considered a serious threat to small farmholder productivity and to local food security. The work presented details an assessment of the global invasion risk of S. frugiperda using 19 bioclimatic variables, altitude and land cover. We calculate Gain, Unsuitable, Stable and Loss of habitat for S. frugiperda comparing four future scenarios against the current baseline scenario. The results show that under various habitat suitability scenarios S. frugiperda will continue to be invasive and endemic. It emphasizes the ongoing need for adaptive and integrated pest management in recently invaded regions to better manage this insect, minimize crop loss and to maintain food security into the future.
An Improved ARO Model for Task Offloading in Vehicular Cloud Computing in VANET
Authors: R Mohan Das , Thirumalraj Arunadevi , T Rajesh 
Published: August 2023

Abstract
Vehicle-to-vehicle (V2V) communication enables a network of automobiles to perform collaborative computing, giving rise to the concept of a "vehicular cloud" (VC). However, without the need for edge nodes or cloud servers, vehicles can carry out applications needing the massive amount of processing cooperatively on their own by creating a Vehicular Ad-Hoc Network (VANET). Managing the recurrent topology alteration caused by vehicle mobility is a significant challenge for VANET cooperative computing. In this research, we present a V2V-based cooperative computing approach. The suggested method takes into account the distance between vehicles while choosing which ones to collaborate with, and it waits task offloading until the last possible moment to ensure a stable and energy-efficient cooperative computing environment. Despite its competitive performance when compared to other MH algorithms, the artificial rabbits optimisation (ARO) algorithm still suffers from poor accuracy and the issue of becoming trapped in solutions. By antagonism methods, this research creates selective opposition version of the artificial rabbit procedure (LARO), which eliminates the negative consequences of these shortcomings. To begin, during the random concealment phase, a Lévy flight strategy is implemented to increase population diversity and dynamics. The algorithm's convergence accuracy is enhanced by the richness of its various population samples. The tracking efficiency is improved, and ARO is kept from getting stuck in its existing local solutions by adopting the selective opposition technique. In comparison to traditional static scheduling techniques, the suggested strategy improves upon both energy efficiency and network reliability.
Proton Pump Inhibitors Use is Associated with Increased Liver Steatosis: A Nationally Representative Study
Authors: Yu Hongsheng , Li Mingkai , Yang Bilan , Sun Huiying , Jiang Hao , Liang Zixi , Smayi Abdukyamu , Wu Bin , Yang Yidong 
Published: August 2023

Abstract
Purpose
Despite the generally considered safety of proton pump inhibitors (PPIs), growing evidence and concerns have raised questions about their potential long-term complications. This study aimed to investigate the association between PPIs therapy and the prevalence of hepatic steatosis and liver fibrosis in the outpatient population of the United States.
Methods
The study included 7,395 individuals aged 20 years and older who underwent hepatic vibration-controlled transient elastography (VCTE) examinations. Data were obtained from the 2017 and March 2020 pre-pandemic National Health and Nutrition Examination Survey.
Results
Among the 7,395 adults included in this study (mean age, 50.59 years; 3,656 males), 9.8% had a prescription for PPIs. After multivariable adjustment, the use of PPIs was significantly associated with hepatic steatosis (odds ratio [OR], 1.25; 95% confidence interval [CI], 1.02–1.53). Prolonged use of PPIs was found to increase the risk of developing hepatic steatosis over time (p for trend = 0.006). Sensitivity analyses using different definitions of hepatic steatosis, such as controlled attenuation parameter ≥ 285 dB/m (OR, 1.19; 95% CI, 1.01–1.40), nonalcoholic fatty liver disease (OR, 1.50; 95% CI, 1.16–1.93), and metabolic dysfunction associated steatotic liver disease (OR, 1.26; 95% CI, 1.05–1.52), consistently showed an association between PPIs prescription and hepatic steatosis.
Conclusion
The administration of PPIs therapy has been found to be linked with heightened hepatic steatosis in US adults, although no significant correlation was observed with liver stiffness, as determined by VCTE.
Identification of Common Genes and Pathways Underlying Imatinib and Nilotinib Treatment in CML: a Bioinformatics Study
Authors: Hekmatshoar Yalda , Saadat Yalda Rahbar , Özkan Tülin , Bozkurt Süreyya , Gürel Aynur Karadağ 
Published: August 2023

Abstract

Imatinib (IMA) and nilotinib are the first and second generations of BCR-ABL tyrosine kinase inhibitors which widely applied in chronic myeloid leukemia (CML) treatment. Here we aimed to provide new targets for CML treatment by transcriptome analysis. Microarray data GSE19567 was downloaded and analyzed from Gene Expression Omnibus (GEO) to identify common genes which are downregulated or upregulated in K562-imatinib and K562-nilotinib treated cells. The differentially expressed genes (DEGs) were assessed, and STRING and Cytoscape were used to create the protein–protein interaction (PPI) network. In imatinib and nilotinib treated groups’ comparison, there were common 626 upregulated and 268 downregulated genes which were differentially expressed. The GO analysis represented the enrichment of DEGs in iron ion binding, protein tyrosine kinase activity, transcription factor activity, ATP binding, sequence-specific DNA binding, cytokine activity, the mitochondrion, sequence-specific DNA binding, plasma membrane and cell-cell adherens junction. KEGG pathway analysis revealed that downregulated DEGs were associated with pathways including microRNAs in cancer and PI3K-Akt signaling pathway. Furthermore, upregulated DEGs were involved in hematopoietic cell lineage, lysosome and chemical carcinogenesis. Among the upregulated genes, MYH9, MYH14, MYL10, MYL7, MYL5, RXRA, CYP1A1, FECH, AKR1C3, ALAD, CAT, CITED2, CPT1A, CYP3A5, CYP3A7, FABP1, HBD, HMBS and PPOX genes were found as hub genes. Moreover, 20 downregulated genes, YARS, AARS, SARS, GARS, CARS, IARS, RRP79, CEBPB, RRP12, UTP14A, PNO1, CCND1, DDX10, MYC, WDR43, CEBPG, DDIT3, VEGFA, PIM1 and TRIB3 were identified as hub genes. These genes have the potential to become target genes for diagnosis and therapy of CML patients.
Ovulation Induction in Polycystic Ovarian Syndrome: A Review to Contemporary approaches
Authors: Chouhan Preeti , Garg Ayush Kumar 
Published: August 2023

Abstract
PCOS or polycystic ovarian syndrome is an endocrine disorder that impacts women's reproductive health and causes them to be infertile. Anovulation is the most common cause of PCOS infertility, although it is not alone. The ongoing hormonal imbalance causes complications such as multiple cysts in ovaries, an irregular menstrual cycle, and insulin resistance leading to infertility. A few of the reasons for PCOS have been discovered as several potential genes. PCOS is a heterogeneous syndrome that primarily affects women between the ages of 18 and 44. Several methods of ovulation induction can be made to make females fertile. Recent research has been conducted on ovulation induction using mediation, surgery, lifestyle changes, and symptom treatment. On the other hand, each of these methods was limited to single or single-pathway research. Because PCOS is complex involving a gene regulatory milieu, it may be prone to the transient, self-limiting occurrence of ENR. To induce ovulation in PCOS patients, genomic-based assessment is needed for therapeutic purposes.
Retrospective analysis of preoperative application of triple-modal pre-rehabilitation on postoperative recovery of colorectal cancer patients
Authors: HUANG Jing-Qiong , XIAO Ying , WANG Rong , GU Ling , ZHANG Lin-Tong , GU Dan , LI Xiang-Sheng , XU Cong , DU Guang-Sheng , XIAO Wei-Dong 
Published: August 2023

Abstract
Purpose
To retrospectively analyze the difference between triple-modal pre-rehabilitation and common treatment in patients with colorectal cancer (CRC).
Methods
A total of 145 patients with CRC diagnosed by pathology and admitted to our hospital for surgery between June 2020 and June 2022 were included in the study. All patients were divided into two groups: the triple-modal pre-rehabilitation group (pre-rehabilitation group) and the common treatment group. The triple-modal pre-rehabilitation strategy included exercise (3–5 times per week, with each session lasting more than 50 min), nutritional support and psychological support. The study was designed to assess the potential of the pre-rehabilitation intervention to accelerate postoperative recovery by assessing the 6-minute walk test, nutritional indicators and HADS score before and after surgery.
Results
The pre-rehabilitation intervention did not reduce the duration of initial postoperative recovery or the incidence of postoperative complications, but it did increase the patients' exercise capacity (as determined by the 6-minute walk test), with the pre-rehabilitation group performing significantly better than the common group (433.0 [105.0] vs. 389.0 [103.5], P < 0.001). The study also found that triple-modal pre-rehabilitation was beneficial for the early recovery of nutritional status in surgical patients and improved anxiety and depression in patients after surgery, especially in those who had not received neoadjuvant therapy.
Conclusion
The triple-modal pre-rehabilitation strategy is of significant importance for reducing stress and improving the functional reserve of patients with colorectal cancer (CRC) during the perioperative period. The results of our study provide further support for the integration of the triple-modal pre-rehabilitation strategy into the treatment and care of CRC patients.
Robotic lobectomy with a single robotic stapler from one 12-mm port: a multi-institutional study
Authors: Inoue Yoshimasa , Fujiu Koichi , Endo Tetsuya , Hamanaka Rurika , Tanaka Hiroto , Takei Hidefumi , Oda Makoto 
Published: August 2023

Abstract

Objectives: The introduction of the robotic stapler has made it possible to perform a robotic lobectomy from the console in complete autonomy. The robotic stapler fits a 12-mm port, which is larger than the standard 8-mm port and increases the risk of postoperative neuralgia. However, in many cases, to cover all possible angles of approach, two 12-mm ports are preferably placed. Meanwhile, limiting instruments and simplifying surgical procedures are also required to reduce costs.
Methods: We assessed the feasibility of robotic lobectomy with a single type of robotic stapler inserted through one 12-mm port placed at the anterior tip of the lower intercostal space, and applied a SureForm45 Curved-Tip (Intuitive Surgical Inc., Sunnyvale, CA, USA) in a multicenter setting. We also investigated the potential cost-saving of using an additional 60-mm stapler for interlobar division.
Results: A total of 135 lobectomy cases were enrolled. In all the cases, all stapling procedures were completed using a SureForm45 Curved-Tip inserted from the designated 12-mm port. We found that it was less expensive to use the SureForm60 if more than six SureForm45 Curved-Tips were needed for interlobar division. Nevertheless, in our series, only one case (0.7%) met this requirement.
Conclusion: The use of a single type of stapler from one 12-mm port in a robotic lobectomy is a technically feasible approach, which expected to allow for surgical simplification, minimize the risk of neuralgia, and reduce inventory costs.
WES-based Screening for Every Newborn - the Future is Now
Authors: Tolmacheva Ekaterina , Shubina Jekaterina , Maslennikov Dmitry , Kochetkova Taisiya , Mukosey Irina , Sadelov Igor , Goltsov Andrey , Ekimov Aleksey , Rogacheva Margarita , Stupko Olga , Dokshukina Alina , Vasiliev Grigory , Bolshakova Anna , Kovalskaia Valeriia , Korovko Anastasia , Pomerantseva Ekaterina , Tsabai Polina , Zaretskaya Nadezhda , Buyanovskaya Olga , Karetnikova Natalia , Degtyareva Anna , Bokerija Ekaterina , Kholin Alexey , Degtyarev Dmitry , Trofimov Dmitry , Sukhih Gennady , Pavlova Nadezhda , Kuznetsova Maria , Rebrikov Denis , Grebenshikova Elena 
Published: August 2023

Abstract
The effective implementation of WES and WGS-based diagnostics in the management of children afflicted with genetic diseases and the rapid decrease in the cost of NGS makes the idea of newborn genetic screening very appealing. Such NGS-based screening greatly increases the number of diseases that can be detected compared to conventional newborn screening, as the latter being aimed at early detection of a limited number of inborn diseases. Moreover, genetic testing provides new possibilities for family members of the proband, as many variants responsible for adult-onset conditions are inherited from the parents. However, the idea of NGS-based screening in healthy children raises issues of medical and ethical integrity as well as technical questions including interpretation of the revealed variants. A few pilot studies have shown that both parents and medical professionals have moved forward and are enthused about these new possibilities. However, the number of participants in studies so far has been limited to a few hundreds, which greatly restricts the scope of potential findings. Our current study includes over 7,000 infants born at our center between February 2021 and May 2023. Clinically significant variants that cause treatable or preventable disorders were observed in 0.9% of inconspicuous infants, 2.1% of the screened newborns being found to carry variants associated with monogenic diseases with incomplete penetrance or late onset and 0.3% having chromosomal abnormalities. Here we report our results and address questions regarding interpretation of variants in newborns who were presumed to be healthy.