bluuebunny/crossref_metadata_2025_split huggingface dataset:
Changes in Radiomic and Radiologic Features in Meningiomas after Radiation Therapy
Authors: Jo Sang Won , Kim Eun Soo , Yoon Dae Young , Kwon Mi Jung 
Published: July 2023

Abstract
Objectives
This study evaluated the radiologic and radiomic features extracted from magnetic resonance imaging (MRI) in meningioma after radiation therapy and investigated the impact of radiation therapy in treating meningioma based on routine brain MRI.
Methods
Observation (n = 100) and radiation therapy (n = 62) patients with meningioma who underwent MRI were randomly divided (7:3 ratio) into training (n = 118) and validation (n = 44) groups. Radiologic findings were analyzed. Radiomic features (filter types: original, square, logarithm, exponential, wavelet; feature types: first order, texture, shape) were extracted from the MRI. The most significant radiomic features were selected and applied to quantify the imaging phenotype using random forest machine learning algorithms. Area under the curve (AUC), sensitivity, and specificity for predicting both the training and validation sets were computed with multiple-hypothesis correction.
Results
The radiologic difference in the maximum area and diameter of meningiomas between two groups was statistically significant. The tumor decreased in the treatment group. A total of 241 series and 1691 radiomic features were extracted from the training set. In univariate analysis, 24 radiomic features were significantly different (P < 0.05) between both groups. Best subsets were one original, three first-order, and six wavelet-based features, with an AUC of 0.87, showing significant differences (P < 0.05) in multivariate analysis. When applying the model, AUC was 0.76 and 0.79 for the training and validation set, respectively.
Conclusion
In meningioma cases, better size reduction can be expected after radiation treatment. The radiomic model using MRI showed significant changes in radiomic features after radiation treatment.
Defining “early palliative care” for adults diagnosed with a life-limiting illness: A scoping review
Authors: Kircher Colleen E , Hanna Timothy P. , Tranmer Joan , Goldie Craig E. , Ross-White Amanda , Moulton Elizabeth , Goldie Catherine L. 
Published: July 2023

Abstract
Background: Palliative care is for people suffering from life-limiting illnesses that focuses on providing relief from symptoms and stress of illness. Previous studies have demonstrated that specialist palliative care consultation delivered earlier in the disease process can enhance patients’ quality of life, reduce their symptom burden, reduce use of hospital-based acute care services and extend their survival. However, various definitions exist for the term early palliative care (EPC).
Objective: To investigate how EPC has been defined in the literature for adults with life- limiting illnesses.
Methods: This review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines and the follows the Joanna Briggs Institution methodology for scoping reviews.
Results: We identified 116 articles between 2008-2020 which met inclusion criteria. Five categories of operational definitions for EPC emerged: 1) time-based (time from advanced cancer diagnosis to EPC initiation); 2) prognosis-based (prognosis or the ‘surprise question’); 3) location-based (access point within the healthcare system such as outpatient setting); 4) treatment-based (physician’s judgement or prior to specific therapies); and 5) symptom-based (using symptom intensity questionnaires). Many studies included patients with cancer (n=78), with the most common definition category being time-based (n =41). Amongst studies focusing on multiple or non-cancer diagnoses (n=38), the most common definition category was symptom-based (n =13).
Conclusion: Our findings provide a useful reference point for those seeking to understand the scope and breadth of existing EPC definitions in cancer and non-cancer illnesses and contemplate their application within clinical practice
Moderate static magnetic field promotes fracture healing and regulates iron metabolism in mice
Authors: Wang Shenghang , Liu Yuetong , Lou Chenge , Cai Chao , Ren Weihao , Liu Junyu , Gong Ming , Shang Peng , Zhang Hao 
Published: July 2023

Abstract
Background
Fracture is a prevalent orthopedic disease. Static magnetic fields (SMFs) are known to aid in maintaining bone health, but the effect and mechanism on fracture is still unclear. This study is aim to investigate the effect of moderate static magnetic fields (MMFs) on bone structure and metabolism during fracture healing.
Methods
Eight-week-old male C57BL/6J mice were fractured at tibia, and following treatment under geomagnetic field (GMF) and MMF. The microarchitecture and mechanical properties were examined by micro-computed tomography (Micro-CT), and 3-point bending. endochondral ossification and bone remodeling were evaluated by bone histomorphometric and serum biochemical assay. Additionally, the atomic absorption spectroscopy and ELISA were used to detect the effect of MMF on iron metabolism in mice.
Results
MMF exposure increased bone mineral density (BMD), bone volume per tissue volume (BV/TV), mechanical properties, and proportion of mineralized bone matrix of the callus, and reduced the proportion of cartilage in the callus area. Meanwhile, MMF exposure increased the number of osteoblasts in callus on the 14th day and reduced the number of osteoclasts on the 28th day of fracture healing. Furthermore, MMF exposure increased PINP and OCN levels, and reduced the TRAP-5b and β-CTX levels in serum. The MMF exposure reduced liver and callus’s iron content and serum ferritin, while increasing the serum hepcidin concentration.
Conclusions
MMF exposure could accelerate fracture healing via promote the endochondral ossification and bone formation, while regulating systemic iron metabolism during fracture healing. This investigation indicates that MMF could be used as a physical therapy for fractures.
The Relationship Between Passion and Athlete Identity in Sport: The Mediating and Moderating Role of Dedication
Authors: Mergan Barış , Uğraş Sinan , Çelik Talip , Hidayat Yusuf , Özman Cemal , Üstün Ümit Doğan 
Published: July 2023

Abstract

Background:In addition to the fact that the concept of passion in sports plays a significant role in the formation of the identity concept of athletes, the dedication of athletes to the sports branches they are interested in also has a significant impact on their passion for the sport they are interested in as well as their identity as an athlete. In this direction, the research aims to investigate the role of dedication as a mediator and regulator in the relationship between athlete identity and passion in sport.Methods:The research was designed using the quantitative research technique of relational surveying. As data collection instruments for the research, the athlete identity scale, the passion in sport scale, and the sports commitment scale were utilized. 237 amateur and professional athletes, of which 142 were male and 95 were female (Mage=22.7), participated voluntarily in the study by random sampling. The data were analyzed with the PROCESS and Jamovi programs in order to examine the direct and indirect effects.Results:Significant effects of sports passion on commitment and athlete identity were found. Since both dedication and athlete identity had a significant effect on passion for sports, it was determined that passion for sports continues to influence athlete identity through the medium of dedication. The regulatory significance of medium, high, and low values of devotion was determined.Ethics approval number:226394, date of registration: 03/11/2022Conclusion:On the basis of the results of the statistical analyses, it was determined that the concept of dedication has a mediating and regulating effect on the relationship between sports passion and athlete identity.
Impact of ultrasound emulsification on the physicochemical properties of emulsions stabilised by quinoa protein isolates at different pHs
Authors: Yang Zhi , Cheng Lirong 
Published: July 2023

Abstract
Ultrasonication (20 kHz, 19.9 W/10 mL sample) was used to form O/W emulsions stabilised by quinoa protein isolate (QPI) particles at 3 wt%. Effects of pH (3, 5, 7, 9) and oil contents (20%, 40%, and 60%) on rheological properties and microstructural characteristics of emulsions were investigated. All emulsions show viscoelastic behaviours and form a network structure comprising aggregated oil droplets and QPI particles. Emulsions stabilised by QPI at pH 5 showed largest droplet sizes and lowest gel strength due to extensive aggregation of proteins around the isoelectric point (pI ~ 4.5). The gel strength (G´(1 Hz)) were enhanced when the oil content increased and reached ~ 1100–1350 Pa at 60% oil content at different pH. This could be attributed to a tighter packing of oil droplets at 60% oil. Confocal laser scanning microscopy (CLSM) and transmission electron microscopy (TEM) revealed that interdroplets bridging and voids filling of QPI particles between oil droplets are critical in formation of aggregated emulsions network. Emulsions stabilised by QPI at pH 7 and 9 possessed thinner interfacial layers compared to those at pH 3 and 5. Finally, this study shows a potential of using ultrasonication to prepare gel-like emulsions stabilised by QPI, broadening applications of quinoa proteins in making dairy substitutes with semi-solid textural characteristics.
Parental stress and depression in the NICU: an analysis of psychosocial evaluations, infant factors, and stress-related salivary biomarkers
Authors: Rubin Lewis , Wolfe Jessica , Pels Taylor , Ressel Claire , Ruben Lewis 
Published: July 2023

Abstract
Parents of NICU infants frequently experience psychosocial stress and depression.
This prospective observational study aimed to determine (a) parental/infant risk factors for parental depression/stress and (b) associations with salivary stress biomarkers.
Parents of NICU infants (predicted hospital stay >2 weeks) were eligible. Parental salivary samples and the Edinburgh Postpartum Depression Scale (EPDS) and Perceived Stress Scale were obtained in week one, at six weeks, and near discharge.
Results were obtained for 66 parents (36 mothers, 30 fathers) of 39 singleton infants. On initial EPDS, 21% of parents (22% of mothers, 33% of fathers) scored sufficiently high (>12) to warrant referral for support/counseling services. Elevated EPDS was associated with parental AM cortisol and infant illness severity.
Self-reported stress differed between mothers and fathers. Salivary stress biomarkers, coupled with validated screening questionnaires, are useful in detecting and intervening with parents at risk for stress and depression during their infants’ NICU admission.
HBK-15, a multimodal compound, induces procognitive effects through modulating hippocampal LTP and enhancing theta-gamma coupling in mice
Authors: Pytka Karolina , Sałaciak Kinga , Lustyk Klaudia , Szafarz Małgorzata , Inteiro-Oliveira Sara , Diogenes MJ , Xapelli Sara , Schnur Paulina , Morton Lucy , Moran Erin , Ferreira Jacques , Sakata Shuzo 
Published: July 2023

Abstract
Neuropsychiatric disorders present with an array of emotional and behavioral symptoms, as well as cognitive deficits. Likely rooted in a complex pathophysiology involving glutamatergic neurotransmission imbalance, cognitive deficits frequently elude treatment by current pharmacotherapies. This highlights the pressing need for innovative drugs specifically targeting and ameliorating cognitive deficits in neuropsychiatric disorders. Here we show that HBK-15, a multimodal compound, exhibits robust antiamnesic properties across several MK-801-induced mouse models of memory deficits, likely through counteracting LTP decline and enhancing theta-gamma coupling in the hippocampus. HBK-15 has shown efficacy in mitigating MK-801-induced cognitive deficits across recognition, emotional, and spatial memory domains without impacting motor skill learning. Its protective effects spanned the encoding, consolidation, and retrieval phases of memory processing. Furthermore, the test compound counteracted the decrease in the hippocampal LTP magnitude caused by MK-801, probably via influencing the L-type voltage-gated calcium channels (Cav1.2). Interestingly, HBK-15 and MK-801 exhibited opposing effects on the coupling between theta and gamma oscillations in the hippocampus. The promotion of theta-gamma coupling by HBK-15 suggests that the compound holds promise for enhancing learning and memory processes. Overall, our research underscores the potential of HBK-15 and compounds of a similar receptor profile in developing effective therapeutic strategies for cognitive deficits in neuropsychiatric conditions such as depression or schizophrenia.
Packet Alignment for Random Access in 5G Massive Machine Type Communication with Heterogeneous Packet Lengths
Authors: Woo Tai-Kuo , Fu Chen-Hua 
Published: July 2023

Abstract
Random access plays a critical role in mMTC networks that consist of a myriad number of heterogeneous IoT devices to meet the demand of applications in a large geographical area. In this paper, we propose using packet alignment for framed slotted Aloha, where packets are aligned to the chunks of time slots according to the lengths of the packets generated by the devices. The packet length dependent alignment ensures that the collision windows are relatively small, where the devices with varying packet lengths view the frame partitioned into chunks of time slots differently. In this paper, packet alignment is used in combination with the packet squeezing to enhance the throughput in framed slotted Aloha. Furthermore, the age of information can be easily included in the proposed approach to emphasize the importance of data freshness. In the performance evaluation, analytical model of the proposed packet alignment alongside with packet squeezing demonstrates that the throughput of framed slotted Aloha in the context of massive machine type communications in 5G can reach 0.9.
Ginsenosides Rh2 and Rg3 exert their anti-cancer effects on non-small cell lung cancer by regulating cell autophagy and choline-phosphatidylcholine metabolism
Authors: Chen Qiu-Fang , Qiu Yue , Wang Lin , Liu Bi-Li , Zhao Min 
Published: July 2023

Abstract
Background: Ginseng (Panax ginseng C. A. Meyer) herb itself and its derived preparations (e.g. Shenmai injection) are often prescribed for cancer patients as Traditional Chinese Medicines clinically in China. Ginsenosides Rh2 and Rg3 are two of main active components of ginseng. They have significant cytotoxic effect against non-small cell lung cancer (NSCLC), but the mechanisms are not very clear, especially lack of research on the combination of cell autophagy and metabolism. This study explores the mechanism of ginsenosides Rh2 and Rg3 against NSCLC from these two aspects.
Methods: In this study, we investigated the regulatory effects of ginsenosides Rh2 and Rg3 on cellular autophagy and metabolism in non-small cell lung cancer cell lines. Their regulations of cellular autophagy were detected by immunofluorescence, MDC staining, and transmission electron microscopy, while their regulations of cellular metabolism were detected by cellular metabolomics.
Results: Our results showed that ginsenosides Rh2 and Rg3 can significantly induce cell autophagy, and can lead to autophagic cell death through endoplasmic reticulum stress-autophagy axis, similar to ginseng total ginsenosides extract (TGS). They also significantly regulate the cell metabolome at the same time. The regulatory effect of ginsenosides Rh2 and Rg3 on the metabolism of choline-phosphatidylcholinemay be the cellular metabolic mechanism of their cytotoxicity.
Conclusion: Our findings suggested that ginsenosides Rh2 and Rg3 could induce autophagic cell death and regulate choline-phosphatidylcholine metabolism in NSCLC cells. This study has a new understanding of the antitumor mechanism of ginsenosides Rh2 and Rg3, and suggests a new direction of studying the pharmacological mechanism of natural active components.
Critical Analysis of Mobility Models on Power Consumption of MANET’S AODV Protocol
Authors: VARSHNEY PANKAJ KUMAR , WADHWANI GANESH KUMAR , KUMAR SHRAWAN , KUMAR GAURAV , SAIFULLA M A 
Published: July 2023

Abstract
Mobile Adhoc Networks (MANETs) permit mobile nodes to communicate devoid of any sustain of predetermined and federal network as it does not follow any preset network communications and all nodes are gratis to travel from one position to a further. Power consumption or energy constraints play an important role in the flow of information between nodes. In the dynamic topology of MANETs, energy or battery is a huge difficulty to keep the mobile node running for a long time. Any node can move from one position to another in a consistent manner, making it difficult to predict the movement of any node in a particular order. Due to this dynamic change in topology the route establishment and its maintenance becomes complicated. Hence energy utilization of the node is one of the parameters that may change the performance of MANETs. In this paper, simulation result based on AODV routing protocol with 50 random mobile nodes under file and random waypoint mobility models concerning generic, mica-motes and micaZ energy models have been analyzed. Simulation outcomes imply that the file mobility model exhibits superior preference over the random waypoint mobility models in generic, mica-motes and micaZ energy models
Bayesian belief network modelling of the challenges associated with hybrid solar-diesel electricity from the end users’ perspective in Bugala Island in Uganda
Authors: Kayima Patrick , Semakula Henry Musoke , Wasswa Hannington , Mugagga Frank , Mukwaya Paul Isolo 
Published: July 2023

Abstract
Background
A hybrid solar-diesel energy system (HSDES) was installed on Bugala Island located on Lake Victioria in Uganda to increase access to clean, affordable, reliable, and sustainable energy, which is essential for protecting the environment while improving living conditions, human health, and local economic development. However, the challenges associated with HSDES generated electricity from the end-users’ perspective are still unknown. Since these challenges are complex, stochastic, nonlinear, and multidimensional, this study aimed at utilizing a Bayesian belief network (BBN) modelling approach to identify, and rank the challenges experienced by energy consumers on the Island in an intergrated format.
Methods
A cross-sectional research design was employed where a total of 237 randomly selected respondents were involved in this study. Quantitative data were gathered using semi-structured questionnaires. The BBN model was developed basing on well established guidelines and modelling protocols. Using the K-fold partitioning approach (K = 2), the casefile (n = 237) was randomly partitioned into a training portion (70%, n = 165) used to populate the model, and test dataset (30%, n = 72), with which accuracy was assessed. Model accuracy was evaluated using metrics of sensitivity, and predication performance.
Results
The developed model was 81.7% accurate in predicting the challenges correctly. The model's spherical payoff was 0.87 with the logarithmic and quadratic losses of 0.33 and 0.23, respectively indicating a strong predictive power and the model’s classification power. The probability of households to experience significant challenges associated with HSDES generated electricity was 30.6%. The rate of damage of electric appliances increased by 15.6 percentage points. Cases of faulty electric meters increased by 25.8 percentage points. The unit cost of electricity, and the cost of power connection also increased by 1.9 and5.5 percentage points respectively. Cases of electrocution increased by 2.4 percentage points while load shedding increased by 4.7 percentage points.
Conclusion
This study provides the key top ranked challenges that should be given priority in an effort to expand hybrid energy on Bugala Island. We conclude that BBN modelling approach is a promising tool in the field of hybrid renewable energy systems on Islands with potential applications due to its versatility.
Estimating the value of off-grid electricity benefits for rural households: Evidence from rural Sumba, Indonesia
Authors: Wibisono Hafidz , Lovett Jon C. , Wen Cheng , Suryani Siti 
Published: July 2023

Abstract
Background Off-grid renewable electricity generation and distribution has become a cost effective way to supply electricity in rural areas remote from the grid system. However, in addition to the risk of not being able to pay for full cost tariffs, beneficiaries may not have the skills or time for the institutional and technical requirements to operate and maintain the technology. This might lead to sub-optimal functioning of off-grid renewable power plants and potentially to damage and abandonment. This raises the question of whether off-grid electricity benefits outweigh the effort and costs experienced by rural communities.Results We conducted a cost-benefit analysis of off-grid electricity in rural Sumba Island, Indonesia, which has been a focal area for implementation of off-grid electricity systems under the Indonesian government 'Iconic Island' programme. The research found a positive benefit-cost ratio when both market and non-market values were estimated suggesting that electricity is advantageous for rural households even without supporting interventions.Conclusions In conclusion we highlight the significance of non-market benefits of electricity. We argue that estimating the value of perceived benefits of electricity is pivotal for making decisions about intervention and formulating investment strategies for establishment of off-grid electricity systems.
Prominent Eustachian valve complicated by thrombus
Authors: kalkoul hamza 
Published: July 2023

Abstract
The Eustachian valve is an embryological remnant of the valve of the inferior vena cava. It may be prominent in some individuals, but the echocardiographic appearance of a divided right atrium (RA) as a result of a large Eustachian valve is rare. Sometimes it presents a problem of differential diagnosis with other embryonic remnants of the right atrium, such as the Chiari network. It may be complicated by thrombosis or infective endocarditis. Cardiac imaging plays an important role in diagnosis. The aim of this review is to discuss a rare form of Eustachian valve complicated by thrombosis.
Bilateral adrenal infarction and insufficiency associated with antiphospholipid syndrome and surgery: A case report
Authors: Iijima Yoshihito , Ishikawa Masahito , Motono Nozomu , Uramoto Hidetaka 
Published: July 2023

Abstract
Background
Antiphospholipid syndrome causes systemic arterial and venous thromboses owing to the presence of antiphospholipid antibodies. Adrenal insufficiency is a rare complication of antiphospholipid syndrome. If left untreated, adrenal insufficiency may result in fatal outcomes.
Case presentation:
A 64-year-old man underwent surgery for a left traumatic hemothorax. He concurrently had antiphospholipid syndrome and was receiving warfarin. Postoperatively, he complained of severe lumbar back pain, despite resuming anticoagulation therapy. He developed paralytic ileus and shock. Abdominal contrast-enhanced computed tomography revealed adrenal swelling and increased surrounding retroperitoneal adipose tissue density. Diffusion-weighted abdominal magnetic resonance imaging revealed high-intensity areas in the bilateral adrenal glands. The cortisol and adrenocorticotropic hormone levels were 3.30 µg/dL and 185.1 pg/dL, respectively. The patient was diagnosed with bilateral adrenal infarction and acute adrenal insufficiency. Hydrocortisone was immediately administered. Adrenal insufficiency improved gradually. The patient was discharged after initiating steroid replacement therapy.
Conclusions
The timing of postoperative anticoagulant therapy initiation is controversial. AI due to adrenal infarction should be monitored while anticoagulant therapy is discontinued in patients with APS.