bluuebunny/crossref_metadata_2025_split huggingface dataset:
Indications, Complications, and Early Postoperative Course of Recovery of Intraocular Lens Exchange Surgery: a Single-Center Retrospective Study
Authors: Silva Marcio , Orguel Selim , Becker Matthias , Freiberg Florentina Joyce 
Published: April 2023

Abstract
Purpose To analyze the indications, complications, and early course of recovery of intraocular lens (IOL) exchange surgery.
Material and Methods Records of patients who underwent IOL exchange during a 6-year period at a tertiary referral center were reviewed and the indications and complications after
surgical intervention were analyzed. Their effects on postoperative corrected distance visual acuity (CDVA), intraocular pressure (IOP), use of IOP-lowering medications, and refractive
cylindrical power were assessed.
Results One hundred and seventy-one eyes (165 patients) were investigated. The most frequent indication for IOL exchange was lens dislocation in 163 eyes (95.32%). The main causes of
IOL dislocation were pseudoexfoliation syndrome (PEX) in 98 eyes (57.31%) and complications during cataract surgery in 40 eyes (23.39%). During IOL exchange, an anterior iris-claw fixation
was performed in 159 eyes (92.98%). After significant initial deterioration to 1.59 ± 1.08 logMAR on postoperative day 1 (p ≤ 0.001), the CDVA recovered to preoperative levels within 28
days. A significant decrease in IOP was observed on postoperative day 1 (p = 0.04). The most common postoperative complications were corneal edema in 114 eyes (66.67%) and vitreous
hemorrhage in 67 eyes (39.18%).
Conclusion The high early postoperative prevalence of corneal edema and intraocular hemorrhage was found to affect visual recovery after IOL exchange, causing a significant initial
deterioration of CDVA and a delay of full visual recovery. These findings suggest that surgical approaches minimizing the risk of this type of complications should be favored.
A Clinical Decision Tree to Support Keratoconus Patients Considering Corneal Cross-Linking Combined with Refractive Treatment
Authors: Iselin Katja , Bachmann Lucas , Baenninger Philipp , Sanak Frantisek , Kaufmann Claude 
Published: April 2023

Abstract
Background To develop a fast and frugal decision tree to identify keratoconus patients most likely to benefit visually from the combination of corneal cross-linking (CXL) with
topography-guided photorefractive keratectomy (“CXL plus”).
Patients and Methods The outcome of interest was an improvement in uncorrected distance visual acuity (UDVA) by at least two lines at the 12-month follow-up. Preoperative and
12-month follow-up data from patients who received CXL plus (n = 96) and CXL only (n = 96) were used in a recursive partitioning approach to construct a frugal tree with three variables
(corneal thickness [>/< 430 um], patient interest in CXL plus [yes/no], and tomographic cylinder [</> 3 D]). In addition, we estimated the probability of the outcome from a
multivariate logistic regression model for each combination of variables used in the decision tree.
Results In the complete sample, 101/192 (52.6%) patients improved by at least two lines at the 12-month follow-up. Patients affirmative in all three answers had a 75.6% (34/45)
probability of gaining at least two lines of improvement in UDVA by CXL plus. The statistical model estimated a 66.0% probability for a successful outcome.
Conclusion A fast and frugal tree consisting of three variables can be used to select a patient group with a high likelihood to benefit from CXL plus. The tree is useful in the
preoperative counseling of keratoconus patients contemplating the CXL plus option, an intervention that is not fully covered by many health insurances.
Utilisation du smartphone dans la sémiologie clinique de la dystrophie épithéliale de Cogan
Authors: Masson Alexandre , Villard Frédéric , Finger Manolito , DeGottrau Philippe , Gaillard Marie-Claire 
Published: April 2023

Résumé
Introduction A lʼère du développement massif de la télémédecine, lʼaccès à des photographies à distance est essentiel. Nous avons donc voulu montrer quʼil est possible de réaliser
des photographies de qualité avec des appareils simples à lʼère de lʼimagerie multimodale coûteuse. Nous illustrons que lʼutilisation du smartphone préalablement monté sur une lampe à fente
a permis de recueillir des photographies précises du segment antérieur, notamment dans notre article, avec un cas de dystrophie épithéliale de Cogan.
Matériel et méthodes Lʼinstallation de ce dispositif est détaillée et imagée. Nous avons monté un smartphone sur les oculaires de la lampe à fente (BQ 900 LED Haag-Streit) et pris
des images de la cornée dʼun patient atteint dʼune dystrophie de Cogan bilatérale.
Résultats Des images statiques de qualité des signes cliniques de cette dystrophie ont pu être prises de manière simple et reproductible. Nous avons corrélé ces signes cliniques avec
les caractéristiques OCT typiques de la pathologie.
Discussion La dystrophie de Cogan nʼétant pas une pathologie si fréquente, lʼintérêt ici est double : le recueil de belles photographies à lʼaide dʼun appareil simple et peu coûteux,
ainsi que lʼobservation et la sauvegarde de la sémiologie clinique particulière de cette dystrophie épithéliale. Des publications ont déjà traité de ce sujet, mais nous avons voulu insister
sur le montage de cet appareil sur une lampe à fente, qui permet une bonne observation de la sémiologie ophtalmologique. Notre présentation démontre quʼil est possible dʼobtenir des
photographies du segment antérieur de qualité avec un matériel simple pour une utilisation clinique quotidienne tant en cabinet quʼen milieu hospitalier.
Postoperative Results in the Treatment of Retinal Detachment with Scleral Buckling Surgery
Authors: Neuhaus Caroline , Valmaggia Christophe 
Published: April 2023

Abstract
Background The course after scleral buckling surgery is investigated in patients with rhegmatogenous retinal detachment.
Patients and Methods The Ethics Committee of Eastern Switzerland approved the retrospective single-center study (EKOS19/152, Project ID: 2019-02034). The primary endpoint is the
anatomical reattachment of the retina 3 months after surgery. Secondary endpoints are visual acuity and the occurrence of intra- and postoperative complications. The patient files of all
patients treated for rhegmatogenous retinal detachment with scleral buckling surgery between January 2005 and December 2014 at the Cantonal Hospital of St. Gallen were included.
Results In 165 of 184 patients (89.7%), reattachment of the retina 3 months postoperatively was achieved by single scleral buckling surgery. Treatment of rhegmatogenous retinal
detachment improved patientsʼ visual acuity by an average of 4.8 ETDRS letters. Intraoperatively, subretinal hemorrhage occurred in one patient. Postoperatively, interfering buckling
material was removed in 24 patients (13.1%). A pars plana vitrectomy was performed in six patients (3.2%) due to epiretinal membrane, in two patients (1.1%) due to a macular hole, and in
three patients (1.6%) due to disturbing vitreous opacities.
Conclusions Scleral buckling surgery is an effective and relatively low complication method for the treatment of selected patients with rhegmatogenous retinal detachment.
Tabakentwöhnung bei hospitalisierten Patienten:innen – Stationär einleiten, ambulant fortführen
Authors: Raspe Matthias , Bals Robert , Bölükbas Serve , Faber Gerhard , Krabbe Bernd , Landmesser Ulf , Al Najem Sinann , Przibille Oliver , Raupach Tobias , Rupp Alexander , Rustler Christa , Tuffman Amanda , Urlbauer Matthias , Voigtländer Thomas , Andreas Stefan ,   In Zusammenarbeit mit weiteren medizinischen Fachgesellschaften und Organisationen: Deutsche Gesellschaft für Innere Medizin (DGIM),   Deutsche Gesellschaft für Kardiologie – Herz- und Kreislaufforschung (DGK),   Deutsche Gesellschaft für Angiologie – Gesellschaft für Gefäßmedizin (DGA),   Deutsche Gesellschaft für Hämatologie und Medizinische Onkologie (DGHO),   Deutsche Gesellschaft für Thoraxchirurgie (DGT),   Bundesverband der Pneumologen, Schlaf- und Beatmungsmediziner (BdP),   Verband Pneumologischer Kliniken (VPK),   Deutsche Atemwegsliga,   Deutsche Lungenstiftung,   Deutsche Herzstiftung
Published: April 2023

ZusammenfassungTabakrauchen ist das größte vermeidbare Gesundheitsrisiko. Die Auswirkungen sind individuell und gesellschaftlich gravierend. Dennoch ist die Prävalenz aktuell Tabakrauchender in Deutschland mit ca. 35 % weiterhin hoch. Sorge bereitet zudem ein zuletzt starker Anstieg aktiv rauchender Jugendlicher (14- bis 17-Jährige, aktuelle Prävalenz ca. 16 %) und junger Erwachsener (18- bis 24-Jährige, aktuelle Prävalenz ca. 41 %). Etwa ein Drittel der stationär behandelten Patienten:innen rauchen. Die Hospitalisierung von aktiven Rauchern:innen in Akut- und Rehakliniken ist als „teachable moment“ ein günstiger Zeitpunkt, eine Tabakentwöhnung einzuleiten. Eine Intervention, die im Krankenhaus beginnt und nach der Entlassung mindestens einen Monat lang fortgesetzt wird, führt zu etwa 40 % zusätzlich entwöhnter Patienten:innen. Sie ist wissenschaftlich gut untersucht, effektiv und kosteneffizient. Die poststationäre Anbindung kann an ein Tabakentwöhnungsprogramm, eine Rehabilitationseinrichtung, ein Internet- oder Telefonangebot erfolgen. Es bestehen in Deutschland strukturierte und qualitätsgesicherte Angebote zur Umsetzung sowohl für den stationären als auch für den ambulanten Bereich. Größtes Hindernis für eine breite Etablierung solcher Angebote ist die fehlende Kostenerstattung. Zwei umsetzbare Wege, dies zu ändern, wären die Einführung eines Zusatzentgelts für den bestehenden OPS 9-501 „Multimodale stationäre Behandlung zur Tabakentwöhnung“ sowie die Etablierung von Qualitätsverträgen nach § 110a SGB V. Ein Ausbau der Tabakentwöhnung in Gesundheitseinrichtungen würde die Rauchprävalenz und die damit einhergehenden Erkrankungen sowie die konsekutiven Kosten nachhaltig reduzieren.
Structure of the human respiratory complex II
Authors: Du Zhanqiang , Zhou Xiaoting , Lai Yuezheng , Xu Jinxu , Zhang Yuying , Zhou Shan , Feng Ziyan , Yu Long , Tang Yanting , Wang Weiwei , Yu Lu , Tian Changlin , Ran Ting , Chen Hongming , Guddat Luke W. , Liu Fengjiang , Gao Yan , Rao Zihe , Gong Hongri 
Published: April 2023

Human complex II is a key protein complex that links two essential energy-producing processes: the tricarboxylic acid cycle and oxidative phosphorylation. Deficiencies due to mutagenesis have been shown to cause mitochondrial disease and some types of cancers. However, the structure of this complex is yet to be resolved, hindering a comprehensive understanding of the functional aspects of this molecular machine. Here, we have determined the structure of human complex II in the presence of ubiquinone at 2.86 Å resolution by cryoelectron microscopy, showing it comprises two water-soluble subunits, SDHA and SDHB, and two membrane-spanning subunits, SDHC and SDHD. This structure allows us to propose a route for electron transfer. In addition, clinically relevant mutations are mapped onto the structure. This mapping provides a molecular understanding to explain why these variants have the potential to produce disease.
Membrane protein isolation and structure determination in cell-derived membrane vesicles
Authors: Tao Xiao , Zhao Chen , MacKinnon Roderick 
Published: April 2023

Integral membrane protein structure determination traditionally requires extraction from cell membranes using detergents or polymers. Here, we describe the isolation and structure determination of proteins in membrane vesicles derived directly from cells. Structures of the ion channel Slo1 from total cell membranes and from cell plasma membranes were determined at 3.8 Å and 2.7 Å resolution, respectively. The plasma membrane environment stabilizes Slo1, revealing an alteration of global helical packing, polar lipid, and cholesterol interactions that stabilize previously unresolved regions of the channel and an additional ion binding site in the Ca2+regulatory domain. The two methods presented enable structural analysis of both internal and plasma membrane proteins without disrupting weakly interacting proteins, lipids, and cofactors that are essential to biological function.
The Pretoria Agreement: mere cessation of hostilities or heralding a new era in Ethiopia?
Authors: Gebresenbet Fana , Tariku Yonas 
Published: April 2023

SUMMARY
On 2 November 2022, welcome news came from Pretoria, South Africa. After 10 days of negotiations, the Federal Democratic Republic of Ethiopia (FDRE) and the Tigray People’s Liberation Front (TPLF) signed a Cessation of Hostilities Agreement. This piece situates the importance of the war, and more importantly the agreement, within the longue durée of Ethiopian politics and highlights its importance as a turning point marking the end of the era of the dominance of the TPLF and the beginning of the end of ethno-nationalism's hegemonic centrality to national politics, including at the expense of the Ethiopian state.
Optimization of TiN-based ultra-flexible materials for photothermal and solar harvesting applications
Authors: Nga Do T. , Julie Thudsaphungthong , Ha Chu Viet , Anh Chu Thuy , Nghia Do Chi , Phan Anh D. 
Published: April 2023

Abstract
We propose a theoretical model to investigate photothermal heating of ultra-flexible metamaterials, which are obtained by randomly mixing TiN nanoparticles in polydimethylsiloxane (PDMS). Due to the plasmonic properties of TiN nanoparticles, incident light can be perfectly absorbed in a broadband range (300-3000 nm) to generate heat within these metamaterials. Under irradiation of an 808 nm near-infrared laser with different intensities, our predicted temperature rises as a function of time agree well with recent experimental data. For a given laser intensity, the temperature rise varies non-monotonically with the concentration of TiN nanoparticles. Increasing the TiN concentration leads to a decrease in the heating process since the thermal conductivity grows. A small TiN concentration significantly reduces the absorbed energy and, thus, the system is less heated. When we apply this model to solar heating, we find that the temperature rise is no longer non-monotonic, and the heating efficiency is much lower than in the laser case. Our studies would provide good guidance for future experimental studies on the photothermal heating of broadband perfect absorbers.
Aromatic Volatile Organic Compounds Adsorption on Tungsten Diselenide Monolayer
Authors: Tran Thi Nhan , Luong Thi Theu , Tran Quang Huy , Phung Viet Bac T. , Dinh Van An 
Published: April 2023

Abstract
In this work, we performed a density functional theory calculation to systematically investigate the adsorption and evaluate the adsorption performance of aromatic volatile organic compounds, benzene and toluene, on WSe2 monolayer. The most favourable adsorption configurations of gas molecules with the parallel orientation of the benzene ring to the substrate surface are explored by computing the binding energies as a function of spatial coordinates and carefully optimizing geometrical structures. The calculations pointed out that gas molecules could diffuse across the substrate along the diffusion paths with quite low diffusion potential barriers, about 180 meV for benzene and 130 meV for toluene molecules. We found that both gases are physisorbed on WSe2 monolayer with moderate adsorption energies, short recovery times, and large response lengths. The gas adsorption causes the bandgap reduction of 26 meV and a slight work function increase of the substrate. There is a charge transfer from the substrate onto the gas molecules, this may cause a resistance decrease of the p-type semiconductor substrate. WSe2 monolayer is quite sensitive to benzene and toluene, and could be suggested as an aromatic gas sensing material.
Inorganic nanorods direct neuronal differentiation of bone marrow-derived mesenchymal stem cells
Authors: Vemuri Satish Kumar , Banala Rajkiran Reddy , Nethi Susheel Kumar , Devraj Vijaya Madhuri , P Pavan Kumar , C Thejaswini Lalittha , M Indira Devi , Gurava Reddy AV , GPV Subbaiah 
Published: April 2023

Abstract
Mesenchymal stem cells (MSCs) are multipotent cells and are considered a potential source for tissue and organ repair due to their self-renewal, proliferation, and differentiation abilities. However, in most cases, MSCs are needed to be stimulated with external growth factors to promote their proliferation and differentiation. Over the past decade, it has been demonstrated that nanomaterials could facilitate MSC proliferation and differentiation, and excellent efforts are carried out to investigate their possible modulating pattern and mechanisms for MSC differentiation. Europium hydroxide (EuIII(OH)3) nanorods (EHN) are well-researched for their biomimicking properties and act as a substitute for growth factors that induce cell proliferation, migration, and differentiation. In the current study, the human MSCs were chosen as an in vitro model for evaluating the role of EHN in modulating the differentiation process of MSCs into neuronal and glial lineages. The characterization of MSCs and differentiated neuronal cells observed by flow cytometry, confocal, and gene marker expression studies supported our hypothesis that the EHNs are pro-angiogenic and pro-neurogenic. Finally, altogether our results suggest that EHNs have the potential to play an essential part in developing novel treatment strategies for neurodegenerative diseases and spinal cord injuries based on the nanomedicine approach.
Impact of vehicle electrification on global supply chains and emission transfer
Authors: Nakamoto Yuya , Tokito Shohei , Kito Minami 
Published: April 2023

Abstract
Numerous countries plan to promote increased levels of vehicle electrification. This study demonstrates that, when considering the life cycle of automobiles, higher levels of vehicle electrification over the next 30 years in Japan would generate higher carbon emissions, preventing the country from meeting carbon reduction and neutrality targets in 2030 and 2050, respectively. In 2020, 2030, and 2050, domestic emissions could decrease to 92.5, 72.9, and 49.6 Mt, respectively, while emission transfers to other countries could reach 12.1 Mt (11.5% of the global carbon footprint), 10.4 Mt (12.5%), and 8.7 Mt (14.9%). The results indicate that even if the widespread use of alternative fuel vehicles could reduce domestic emissions, such emissions might be transferred to foreign countries, and blanket promotion of automobile electrification should be avoided. Instead, governments and the automotive industry should take responsibility for global and whole life-cycle emissions of vehicles, not only domestic tank-to-wheel emissions. These results provide baseline information for use in the recommendation measures and international rules to be adopted by the automobile industry stakeholders and policymakers.
Ultrasound Calculation of Fat Volume for Liposuction: A Clinical Software Validation
Authors: Harutyunyan Robert , Gilardino Mirko S , Papanastasiou Vasilios W , Jeffries Sean D , Hemmerling Thomas M 
Published: April 2023

Abstract

Background
Fat manipulation procedures such as liposuction contain a degree of subjectivity primarily guided by the surgeon's visual or tactile perception of the underlying fat. Currently, there is no cost-effective, direct method to objectively measure fat depth and volume in real time.

Objectives
Utilizing innovative ultrasound-based software, the authors aimed to validate fat tissue volume and distribution measurements in the preoperative setting.

Methods
Eighteen participants were recruited to evaluate the accuracy of the new software. Recruited participants underwent ultrasound scans within the preoperative markings of the study area before surgery. Ultrasound-estimated fat profiles were generated with the in-house software and compared directly with the intraoperative aspirated fat recorded after gravity separation.

Results
Participants’ mean age and BMI were 47.6 (11.3) years and 25.6 (2.3) kg/m2, respectively. Evaluation of trial data showed promising results following the use of a Bland Altman agreement analysis. For the 18 patients and 44 volumes estimated, 43 of 44 measurements fell within a confidence interval of 95% when compared with the clinical lipoaspirate (dry) volumes collected postsurgery. The bias was estimated at 9.15 mL with a standard deviation of 17.08 mL and 95% confidence interval between −24.34 mL and 42.63 mL.

Conclusions
Preoperative fat assessment measurements agreed significantly with intraoperative lipoaspirate volumes. The pilot study demonstrates, for the first time, a novel companion tool with the prospect of supporting surgeons in surgical planning, measuring, and executing the transfer of adipose tissues.

Level of Evidence: 4
A survey on algorithms to characterize transcription factor binding sites
Authors: Tognon Manuel , Giugno Rosalba , Pinello Luca 
Published: April 2023

Abstract
Transcription factors (TFs) are key regulatory proteins that control the transcriptional rate of cells by binding short DNA sequences called transcription factor binding sites (TFBS) or motifs. Identifying and characterizing TFBS is fundamental to understanding the regulatory mechanisms governing the transcriptional state of cells. During the last decades, several experimental methods have been developed to recover DNA sequences containing TFBS. In parallel, computational methods have been proposed to discover and identify TFBS motifs based on these DNA sequences. This is one of the most widely investigated problems in bioinformatics and is referred to as the motif discovery problem. In this manuscript, we review classical and novel experimental and computational methods developed to discover and characterize TFBS motifs in DNA sequences, highlighting their advantages and drawbacks. We also discuss open challenges and future perspectives that could fill the remaining gaps in the field.
Statistical summaries of unlabelled evolutionary trees
Authors: Samyak Rajanala , Palacios Julia A 
Published: April 2023

Summary
Rooted and ranked phylogenetic trees are mathematical objects that are useful in modelling hierarchical data and evolutionary relationships with applications to many fields such as evolutionary biology and genetic epidemiology. Bayesian phylogenetic inference usually explores the posterior distribution of trees via Markov chain Monte Carlo methods. However, assessing uncertainty and summarizing distributions remains challenging for these types of structures. While labelled phylogenetic trees have been extensively studied, relatively less literature exists for unlabelled trees that are increasingly useful, for example when one seeks to summarize samples of trees obtained with different methods, or from different samples and environments, and wishes to assess the stability and generalizability of these summaries. In our paper, we exploit recently proposed distance metrics of unlabelled ranked binary trees and unlabelled ranked genealogies, or trees equipped with branch lengths, to define the Fréchet mean, variance and interquartile sets as summaries of these tree distributions. We provide an efficient combinatorial optimization algorithm for computing the Fréchet mean of a sample or of distributions on unlabelled ranked tree shapes and unlabelled ranked genealogies. We show the applicability of our summary statistics for studying popular tree distributions and for comparing the SARS-CoV-2 evolutionary trees across different locations during the COVID-19 epidemic in 2020. Our current implementations are publicly available at https://github.com/RSamyak/fmatrix.