bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gene regulatory accelerators on cloud FPGA
Authors: Costa Penha Jeronimo , Bragança Lucas , Canesche Michael , Ribeiro Dener , Nacif José Augusto M. , Ferreira Ricardo S. 
Published: May 2023

SummaryGene regulatory networks (GRN) are dynamic models in time and space. These models are used to predict diseases and in drugs research. GRN models are discrete, and Boolean graphs can efficiently represent them. However, GRN algorithms explore a large solution space with high computational complexity. This work proposes efficient FPGA‐based accelerators to implement two GRN algorithms: attractor computation and Derrida plot. Nevertheless, FPGA accelerator design and deployment are still a challenge. This work presents an accelerator design framework for AWS Amazon FPGA cloud. The framework simplifies the software (SW) and hardware (HW) generation for GRN accelerators. The user provides a high‐level model for the Boolean GRN, and our tool automatically creates AWS‐ready‐to‐deploy software and hardware components. For the attractor and the Derrida plot computation, the proposed FPGA accelerators are on average and faster than a V100 GPU.
Recovery marketing for conflict sensitive destination: Stakeholders perspective on tourism revival in Kashmir Valley (India)
Authors: Najar Ashaq Hussain , Kour Parvinder , Jasrotia Aruditya 
Published: May 2023

AbstractThis study aims to examine the destination recovery procedures through the stakeholders' lens. It focuses on identifying real‐time implications and opportunities for destination marketing authorities toward tourism revival. This paper utilized a thematic analysis with data sourced through interviews with stakeholders in the tourism industry resulting in the emergence of various subcategories, which were further grouped into six final themes. These themes include the determination and confidence of stakeholders, need for a peaceful environment, recovery from negative media propaganda, tourist awareness, and online marketing to persuade people who have already visited the destination.
Photocatalytic Synthesis of Ultrafine Pt Electrocatalysts with High Stability Using TiO2‐Decorated N‐Doped Carbon as Composite Support
Authors: Shen Le , Wang Zemei , Gong Qi , Zhang Yanrong , Wang Jingyu 
Published: May 2023

AbstractCommercial Pt/C (Com. Pt/C) electrocatalysts are considered optimal for oxygen reduction and hydrogen evolution reactions (ORR and HER). However, their high Pt content and poor stability restrict their large‐scale application. In this study, photocatalytic synthesis was used to reduce ultrafine Pt nanoparticles in‐situ on a composite support of TiO2‐decorated nitrogen‐doped carbon (TiO2−NC). The nitrogen‐doped carbon had a large surface area and electronic effects that ensured the uniform dispersion of TiO2 nanoparticles to form a highly photoactive and stable support. TiO2−NC served as a composite support that enhanced the dispersibility and stability of ultrafine Pt electrocatalyst, owing to the presence of N sites and the strong metal‐support interaction. Relative to Com. Pt/C, the as‐obtained Pt/TiO2−NC had positive shifts of 44 and 10 mV in the ORR half‐wave potential and HER overpotential at −10 mA cm−2, respectively. After an accelerated durability test, Pt/TiO2−NC had lower losses in electrochemical specific area (0.7 %) and electrocatalytic activity (0 mV shift) than Com. Pt/C (25.6 %, 22 mV shift). These results indicate that the developed strategy enabled the facile synthesis and stabilization of ultrafine Pt nanoparticles, which improved the utilization efficiency and long‐term stability of Pt‐based electrocatalysts.
Connecting tiger (Panthera tigris) populations in Nepal: Identification of corridors among tiger‐bearing protected areas
Authors: Bhatt Tek Raj , Castley J. Guy , Sims‐Castley Rebecca , Baral Hem Sagar , Chauvenet Alienor L. M. 
Published: May 2023

AbstractHabitat fragmentation and isolation threaten the survival of several wide‐ranging species, such as tigers, through increased risk from diseases, disasters, climate change, and genetic depression. Identification of the habitat most likely to achieve connectivity among protected areas is vital for the long‐term persistence of tigers. We aimed to improve the mapping of potential transfrontier protected area corridors for tigers by connecting sites within the Terai Arc Landscape in Nepal and to those in India, highlighting targeted conservation actions needed along these corridors to maintain long‐term connectivity. We used least‐cost corridor modeling and circuit theory to identify potential corridors and bottlenecks in the study area. The landscape's resistance to tigers' movement was gathered from expert opinions to inform corridor modeling. We identified nine potential tiger corridors in the Terai Arc Landscape—Nepal that aligned strongly with the remaining intact habitats of the Siwalik landscape, which could facilitate tiger movement. Banke‐Bardia and Chitwan‐Parsa‐Valimiki complexes and Lagga‐Bhagga and Khata corridors were identified as high‐priority conservation cores and corridors. While our model exhibited congruence with most established corridors in the landscape, it has identified the need to enhance existing corridors to improve landscape connectivity. Several pinch points posing an increased risk to connectivity were identified. Most of these were located near the protected area boundaries and along the Nepal–India border. The Siwalik landscape holds the key to long‐term connectivity in the study area; however, immediate conservation attention is needed, particularly at pinch points, to secure this connectivity for tigers. Validation of identified corridors through empirical research and their conservation is a priority.
Silencing of tumoral carbohydrate sulfotransferase 15 reactivates lymph node pancreatic cancer T cells in mice
Authors: Ye Juanjuan , Suizu Futoshi , Yamakawa Keiko , Mukai Yuri , Kato Motohiko , Yoneyama Hiroyuki , Yahagi Naohisa , Matsuda Yoko 
Published: May 2023

AbstractLimited intratumoral T‐cell infiltration in pancreatic ductal adenocarcinoma (PDAC) is an obstacle to immunotherapy, yet the efficient approach to enhance tumor‐infiltrating T cells is not fully established. Here, we show that tumor‐specific knockdown of carbohydrate sulfotransferase 15 (CHST15), a tumor stromal proteoglycan‐synthetic enzyme, suppresses tumor growth in a T‐cell‐dependent manner in a murine model of PDAC. Silencing of tumoral CHST15 unexpectedly expanded CD4+ and CD8+ T cells in tumor draining LN (TDLN), leading to accelerated accumulation of EdU+ proliferating CD4+ and CD8+ T cells and granzyme B+ CD8+ T cells in the tumor. RNA expression analysis indicated that tumoral CHST15 knockdown (KD) downregulated matrix remodeling‐related genes, while upregulated anti‐tumor T‐cell activity‐related genes in both tumor and TDLN. CHST15 KD significantly diminished intratumoral and TDLN Ly6C/G+ myeloid‐derived suppressor cells prior to TDLN T‐cell expansion, suggesting that tumoral CHST15 remotely regulated myeloid‐derived suppressor cell mediated T‐cell suppression in the TDLN. Our findings illustrate a novel immunotherapeutic potential of tumoral CHST15 blockage by reactivating T cells in immune suppressive TDLN of PDAC.
Reducing air pollution through smart energy management in industrial clusters of India
Authors: Dube Sanjay 
Published: May 2023

AbstractSmart energy management, along with clean technologies and advanced pollution control measures has proven to be an effective strategy for reducing air pollution in both developed and transitioning economies and holds significant potential to reduce emissions from industries and power plants—two of the major sources of air pollution in many of India's urban areas.This manuscript presents the results from a project and provides a critical proof of concept to show that developing country cities can achieve significant, measurable reductions in air pollution, Volatile Organic Compound emissions and greenhouse gas emissions through investing in smart energy management and advance control technologies. Achieving this goal, however, requires addressing two key challenges: (1) lack of a demonstrated link between smart energy management and air quality improvements in India; and (2) the need to scale up development, financing, and implementation of smart energy solutions, including energy efficiency and clean technology measures that can help address air pollution in industrialized urban areas, critically polluted areas by offsetting fossil fuel use for diesel‐ and coal‐fired electricity generation.
A bi‐level programming model and differential evolution for optimizing offshore wind farm layout
Authors: Song Erping 
Published: May 2023

AbstractThe optimization of offshore wind farms is mainly performed through the deployment of wind farms and submarine cables to maximize power output and minimize cable costs. However, the above results are affected by the wake effect, equipment layout, and the cost of cables. To effectively complete the deployment of wind turbines and submarine cable lines, first, a bi‐level constrained optimization model based on maximum profit and the shortest route of cable is proposed in this paper; then, a differential evolution and improved Prim algorithm (IPADE) are used to optimize the upper‐ and lower‐level objective function, respectively. Moreover, the fitness values are used to divide the population, and a surrogate model is used to evaluate approximate fitness values for the sub‐population with poor performance; the best individual is selected as the offspring individual according to the approximate fitness values. Next, a clustering method is used to divide the position of the wind farm, and a Prim algorithm based on roulette wheel selection is designed to deploy submarine cables of every subwind farm. Finally, the proposed algorithm is compared with five other popular algorithms under the two wind conditions. The simulation experimental results show that algorithm IPADE performs better than other algorithms in terms of the power output, profit, and the length of cables.
The perfect bail‐in: Financing without banks using peer‐to‐peer lending
Authors: Polyzos Efstathios , Samitas Aristeidis , Rubbaniy Ghulame 
Published: May 2023

AbstractWe explore the potential outcomes for financial stability when using peer‐to‐peer lenders to finance economic activity. Combining Random Regression Forests, a machine‐learning process, with an agent‐based model, we perform simulations on artificial economies with various degrees of adoption of peer‐to‐peer lending. We find that as peer‐to‐peer lenders proliferate, there is increased financial instability, lower GDP and higher unemployment. On the other hand, peer‐to‐peer lending increases the total volume of loans given out but demonstrates a preference towards consumer loans (over corporate loans), which has a negative effect in the long run. Finally, introducing peer‐to‐peer lenders increases the access of the unbanked to services which conventional banking is not able to offer within the extant regulatory framework. Our results can help policymakers as they address the issue of regulation in the peer‐to‐peer finance industry.
Labour reallocation and unemployment fluctuations: A tale of two tails
Authors: Bakas Dimitrios , Panagiotidis Theodore , Pelloni Gianluigi 
Published: May 2023

AbstractThis paper examines the sectoral shifts hypothesis for the US regional labour market using a quantile panel framework. We use a monthly panel dataset that spans over 1990–2016 for the 48 US states and employ a dynamic quantile panel data regression approach to investigate the asymmetric nature of the relationship between sectoral labour reallocation and unemployment fluctuations. The empirical evidence suggests that the impact of the employment dispersion index is relatively small and insignificant for lower levels of unemployment but becomes positive and highly significant for higher rates. Our findings bear out the asymmetry of reallocation disturbances for the US labour market.
Preparing learners to ACT as change agents: Early implementation of leadership curricula in dental education
Authors: Kornegay Elizabeth C , Hayon Ellen , Gisler Susan , Bell Gerald , Wilder Rebecca , Stewart Shadoe , Quinonez Rocio B. 
Published: May 2023

AbstractObjectiveGraduates of dental schools are expected to become leaders in their practices, communities, and profession. Yet, formal leadership training is underutilized in U.S. dental school curricula to help learners develop these skills. The objective of this study was to understand third‐ and fourth‐year dental students’ perceptions of their initial semester of Bell Leadership Institute training as part of the novel Advocate, Clinician, Thinker curriculum at the UNC Adams School of Dentistry.MethodsFocus groups of 52 third‐ and fourth‐year dental students were conducted after the completion of the first semester of leadership seminars. Session notes were transcribed, and qualitative analysis was performed to help elucidate student perceptions of the value and pertinence of the leadership seminars.ResultsParticipants valued the opportunities to self‐reflect, develop listening skills, and learn strategies to address and mitigate conflict through the leadership seminars. Perceptions of seminar length, frequency, and structure were varied. Participants also noted that explicit connections and applications of leadership topics to the field of dentistry would improve the quality of the programing. Feedback from 52 focus group participants suggests a general appreciation for curriculum‐integrated leadership training.ConclusionEarly implementation of seminar‐style leadership training in dental school curricula appears to be a productive avenue for developing critical leadership skills in dental school graduates.
Calcium oxalate crystal macropattern and its usefulness in the taxonomy of Baccharis (Asteraceae)
Authors: Raeski Paola Aparecida , Heiden Gustavo , Novatski Andressa , Raman Vijayasankar , Khan Ikhlas Ahmed , Manfron Jane 
Published: May 2023

AbstractThis study provides a comprehensive account of the various types of calcium oxalate crystals found in the genus Baccharis and assesses the exceptional value of crystal macropatterns for the taxonomy of the genus. The morphotype, occurrence, and chemical composition of the crystals found in the stems and leaves are studied. The 44 species included in this study were selected based on a broad phylogeny‐based sampling covering seven subgenera and 31 sections. These species were chosen to represent all the main phylogenetic lineages of Baccharis; thus, the sampling also represents a comprehensive coverage concerning evolutionary significance for such a large and environmentally and economically important plant group. The samples were analyzed by light microscopy, scanning electron microscopy (SEM), and energy‐dispersive x‐ray spectroscopy (EDS). Several morphotypes of crystals, including druses, crystal sand, styloids and prisms, were present. Based on their chemical composition, the crystals were classified as pure calcium oxalate, mixtures of oxalates and sulfates, and mixtures of oxalates, sulfates, and silica. The crystal macropatterns observed in this study aid in species identification and provide novel data for the taxonomy of Baccharis.Research HighlightsMost species of Baccharis have a specific crystalline pattern. Each species produces a crystal morphotype or a set of morphotypes specific to it. The crystals observed are formed by calcium oxalate.
In Vitro and In Vivo Evaluation of Ultrasound‐Triggered Release From Novel Spinal Device
Authors: Delaney Lauren J. , Isguven Selin , Hilliard Rachel , Lacerda Quezia , Oeffinger Brian E. , Machado Priscilla , Schaer Thomas P. , Hickok Noreen J. , Kurtz Steven M. , Forsberg Flemming 
Published: May 2023

ObjectivesBacterial infection following spinal fusion is a major clinical concern with up to 20% incidence. An ultrasound‐triggered bulk‐release system to combat postsurgical bacterial survival was designed and evaluated.MethodsPolylactic acid (PLA) clips were loaded with vancomycin (VAN) and microbubbles (Sonazoid, GE HealthCare) in vitro. Stability was determined over 14 days. VAN‐loaded clips were submerged in water and insonated using a Logiq E10 scanner (GE HealthCare) with a curvilinear C6 probe. Doppler‐induced VAN release was quantified using spectrophotometry. For in vivo testing, clips were loaded with methylene blue (MeB) solution and Sonazoid. These clips were implanted into a rabbit along the spine at L2 and L5, as well as a pig at L1 and L3, then insonated in Doppler mode using the C6 probe.ResultsSonazoid microbubbles were better preserved when incubated in VAN compared with distilled water at 4°C, 25°C, and 37°C incubation temperatures (P = .0131). Contrast enhancement was observed from both solutions when incubated at 4°C storage conditions. Insonated clips achieved average cumulative VAN release of 101.8 ± 2.8% (81.4 ± 2.8 mg) after 72 hours. Uninsonated clips had only 0.3 ± 0.1% (0.3 ± 0.1 mg) average cumulative VAN release (P < .0001). Clips retrieved from the rabbit did not rupture with insonation nor produce MeB staining of surrounding tissues. In the pig, the PLA film was visibly ruptured and MeB tissue was observed following insonation, whereas the uninsonated clip was intact.ConclusionThese results demonstrate ultrasound‐triggered release of an encapsulated prophylactic solution and provide an important proof‐of‐concept for continuing large animal evaluations for translational merit.
BRIDGEBUILDING FOR A NEW VISION OF GOVERNMENT
Authors: Eggers William D. , Kettl Donald F. 
Published: May 2023

AbstractThe authors, who each have significant experience “improving and monitoring government,” explain their concept of “Bridgebuilders,” people who “transform governance: from hierarchy to networks, from authority to collaboration, from process to mission, and from fuzzy responsibility to a laser‐like focus on results.” They note that in order for government to be more effective and solve problems, they can’t do it alone, that “every effective solution requires the skills of people in many organizations.” They identify ten keys to solutions, which in their words are 1. Knock down barriers; 2. Seek mutual advantage; 3. Nurture private partners; 4. Build trustworthy networks; 5. Grow catalytic government; 6. Focus on outcomes; 7. Make data the language; 8. Redefine accountability; 9. Cultivate cross‐boundary leaders; 10. Make the exceptional routine. The article “focuses on nurturing private partners to help conduct the public’s business.” The authors detail the story of Alan Graham, who founded the Austin, Texas‐based nonprofit Mobile Loaves & Fishes, in 1984. This relates to strategies outlined in the article such as “Convene the important players,” “Rely on third‐party entities,” “Provide greater regulatory flexibility,” “Encourage the free flow of ideas between sectors,” and “Facilitate the cross‐sector pursuit of public purpose.”
FROM PRISON TO PRODUCTIVITY: WHY YOU SHOULD HIRE FORMERLY INCARCERATED PEOPLE
Authors: Swift Melissa 
Published: May 2023

AbstractThe author, who leads Transformation Solutions for Mercer US and Canada, discusses a timely and potentially controversial topic: hiring formerly incarcerated people, a group that has a disproportionately high unemployment rate. However, she points out that structural elements in the U.S. economy mean that organizations will continue to search for qualified workers: “Labor force participation remains below pre‐pandemic levels; the labor force is expected to grow at a far slower rate than in previous decades.” She points to hiring research and reporting at Johns Hopkins Medicine and the Illinois Prison Project, and claims that formerly incarcerated people are not risky hires, and that they are more loyal employees with unique talents. However, it is not that simple: “hiring and retaining this group is far more complicated than simply focusing on them.” She offers hiring strategies such as, “To open up your organization to hire more formerly incarcerated people, you need to also figure out the hidden blockers – what do you assume is needed for roles on your team that might not be needed (but doesn’t formally appear on the job description)?” In addition, “you have to ensure that the very mechanics of the process of getting hired don’t exclude them (even if they technically qualify for the role).”
Sodium Alginate Doped with Magnesium Perchlorate as Solid Biopolymer Electrolytes for Energy Storage Applications
Authors: Rajendran Tamilisai , Pachagoundanpalayam Palanisamy Nachimuthu , Subramanian Selvasekarapandian , Manoharan Vengadesh Krishna 
Published: May 2023

AbstractThis paper deals with development and characterization of the solid biopolymer electrolyte using Sodium alginate as the host biopolymer and magnesium perchlorate used as a doping salt. Membranes are prepared via solution casting technique. Several characterization techniques, such as X‐ray and diffraction, Fourier transform infrared spectroscopy, differential scanning calorimetry, AC impedance spectroscopy, linear sweep voltammetry, and transference number measurement are performed to characterize the prepared biopolymer membrane. The highest ionic conductivity 2.41 × 10−3 S cm−1 is observed for prepared solid biopolymer electrolyte contains 40:60 m wt% of NaAlg:Mg(ClO4)2. The electrochemical stability of highest ion conducting biopolymer membrane is observed at 3.62 V. A primary magnesium battery is constructed using the highest ionic conducting biopolymer membrane and the open circuit voltage of the fabricated magnesium battery is found to be 2.0 V.
Sobolev's inequality in Musielak–Orlicz–Morrey spaces of an integral form
Authors: Ohno Takao , Shimomura Tetsu 
Published: May 2023

AbstractIn this paper, we are concerned with Sobolev's inequality for variable Riesz potentials of functions f in Musielak–Orlicz–Morrey spaces of an integral form over metric measure spaces. As an application and example, we give Sobolev's inequality for double‐phase functionals , where and satisfy log‐Hölder conditions and is non‐negative, bounded and Hölder continuous of order . Further, we obtain the result for Sobolev functions.
Semi‐Solid Supramolecular Ionic Network Electrolytes Formed by Zwitterionic Liquids and Polyoxometalate Nanoclusters for High Proton Conduction
Authors: Li Xiang , Chai Shengchao , Zhai Liang , Guo Haikun , He Haibo , Li Haibin , Wu Lixin , Li Haolong 
Published: May 2023

AbstractFlexible electrolytes with solid self‐supporting properties are highly desired in the fields of energy and electronics. However, traditional flexible electrolytes prepared by doping ionic liquids or salt solutions into a polymer matrix pose a risk of liquid component leakage during device operation. In this work, the development of supramolecular ionic network electrolytes using polyoxometalate nanoclusters as supramolecular crosslinkers to solidify bola‐type zwitterionic liquids is reported. The resulting self‐supporting electrolytes possess semi‐solid features and show a high proton conductivity of 8.2 × 10−4 S cm−1 at low humidity (RH = 30%). Additionally, the electrolytes exhibit a typical plateau region in rheological tests, indicating that their dynamic network structures can contribute mechanical behavior similar to the entangled networks in covalent polymer materials. This work introduces a new paradigm for designing flexible solid electrolytes and expands the concept of reticular chemistry to noncrystalline systems.