bluuebunny/crossref_metadata_2025_split huggingface dataset:
Guidance of adjuvant instillation in intermediate risk non- muscle invasive bladder cancer by drug screens in patient derived organoids. A Single center, Open-label, Phase II trial. GAIN-INST-Trial
Authors: Seiler Roland , Egger Martin , De Menna Marta , Wehrli Saskia , Minoli Martina , Radić Martina , Lyatoshinsky Pavel , Hoesli Raphael , Blarer Jennifer , Abt Dominik , Julio Marianna De-Kruithof 
Published: January 2023

Abstract
Background: In intermediate risk non-muscle-invasive bladder cancer (NMIBC) clinical guidelines suggest an adjuvant instillation with a chemotherapeutic agent. However, the agent and regimen are not clearly defined. Worldwide, less than 15% of patients receive this adjuvant chemotherapeutic instillation. We recently developed a pipeline for the generation of patient derived organoids (PDO) in NMIBC. In this phase II trial, we aim to use our in vitro pipeline to select the most effective drug for chemotherapeutic instillation in NMIBC patients.
Methods: Patients with first diagnosis of intermediate risk NMIBC that are directed to TURBT are enrolled. During TURBT, tumor is sampled, and specimens are directed to generate PDOs. Once the PDOs are formed, drug screens on them for Epirubicin, Mitomycin C, Gemcitabine and Docetaxel are performed. The drug with the highest antitumor activity in vitro will then be selected for 6 adjuvant intravesical instillations once weekly. Thereafter, patients are followed according to clinical guidelines by cystoscopy.
Discussion: The aim of this trial is to use drug screens in PDO to precise treatment selection for adjuvant instillation therapies in patients with intermediate risk NMIBC. The ultimate goal of this trail is to reduce the risk of cancer recurrence. In the future, we aim to conduct clinical multicenter trials with an increased sample size, a broader panel of compounds and a focus on the reduction of cancer recurrence by precision delivery of care.
Trial registration: NCT05024734
Feasibility and efficiency of delayed ovarian stimulation and oocyte banking for fertility preservation after fertility-impairing treatment
Authors: MIQUEL Laura , LIOTTA Julie , HOURS Alice , BOTTIN Pauline , CASTEL Pierre , PERRIN Jeanne , GUILLEMAIN Catherine , COURBIERE Blandine 
Published: January 2023

Abstract
Purpose
The aim of our study was to evaluate the feasibility and efficiency of delayed ovarian stimulation and oocyte banking for fertility preservation after fertility-impairing treatment regardless of the initial disease.
Methods
We conducted a cohort study based on population of women < 40 years of age with diminished ovarian reserve (n = 129). Three groups of women were compared according to the type of initial disease: hematological malignancies, solid tumors, and benign diseases. The endpoints were the number of metaphase II oocytes collected per woman, whether vitrified or immediately used in in vitro fertilization and the cumulative live birth rate per stimulation cycle.
Results
We studied 245 delayed controlled ovarian stimulation cycles in 129 women: 201 for fertility preservation and 44 for in vitro fertilization and fresh embryo transfers. The number of metaphase II oocytes collected per woman after oocyte banking was similar in the three groups, with a mean of 10.7 ± 4.6, 12.3 ± 9.1 and 10.1 ± 7.6 oocytes (NS), respectively. The cumulative live birth rate was 38%, with 8 live births for the 21 women who wanted to conceive.
Conclusion
After fertility-impairing treatment, practitioners should discuss a fertility preservation procedure for banking oocytes, even if a fertility preservation has already been performed.
Post-Infarct Evolution of Ventricular and Myocardial Function
Authors: Janssens K.L.P.M. , Kraamer M. , Barbarotta L. , Bovendeerd P.H.M. 
Published: January 2023

Abstract
Introduction Adverse ventricular remodeling following acute myocardial infarction (MI) may induce ventricular dilation, fibrosis, and loss of global contractile function, possibly resulting in heart failure (HF). Understanding the relation between the time-dependent changes in material properties of the myocardium and the contractile function of the heart may further our understanding of the development of HF post-MI and guide the development of novel therapies.
Methods A finite element model of cardiac mechanics was used to model MI in a thick-walled truncated ellipsoidal geometry. Infarct core and border zone comprised 9.6\% and 8.1\% of the LV wall volume, respectively. Acute and chronic MI were modeled by reducing active stress generation and subsequent step-wise increase of material stiffness.
Results In acute MI, stroke work decreased by 25\%. In the infarct core, fiber stress was reduced but fiber strain was increased, depending on the degree of infarct stiffening. Fiber work density was equal to zero. Healthy tissue adjacent to the infarct showed decreased work density depending on the degree of infarct stiffness and the orientation of the myofibers with respect to the infarct region.
Conclusion We found that the relative loss in pump function in the infarcted heart exceeds the relative loss in healthy myocardial tissue due to impaired mechanical function in healthy tissue adjacent to the infarct. Infarct stiffening did not affect pump function but did affect the distribution of work density in tissue adjacent to the infarct.
Intracellular Acidification in a Rat C6 Glioma Model Following Cariporide Injection Monitored by Chemical Exchange Saturation Transfer Magnetic Resonance Imaging
Authors: Mozaffari Maryam , Nyström Nivin N , Li Alex , Bellyou Miranda , Scholl Timothy J. , Bartha Robert 
Published: January 2023

Abstract
Gliomas are the most common primary brain tumors. Selective acidification of cancerous tissue induced pharmacologically may slow tumor growth and can be detected using magnetic resonance imaging (MRI). The sodium proton exchanger inhibitor cariporide can selectively acidify U87MG gliomas in mice. This study aimed to determine whether cariporide could selectively acidify C6 glioma tumors in rats with an intact immune system. C6 glioma cells were implanted in the right brain hemisphere of ten male Wistar rats. Chemical exchange saturation transfer (CEST) MRI (9.4T) was acquired on days 7–8 (N= 10) and 14–15 (N= 10) after implantation to measure in vivo tissue intracellular pH (pHi) within the tumors and on the contralateral side. Intracellular pH was basic relative to contralateral tissue at both time points (p < 0.05) assessed using the amine and amide concentration-independent detection (AACID) value. On day 14–15, measurements were made before and up to 160 minutes after cariporide injection (N= 6, dose: 6 mg/kg in 2 mL with 10% DMSO). Twenty minutes after drug injection, the average AACID value in the tumor significantly increased by ∼6.4% compared to pre-injection, corresponding to 0.31 ± 0.20 lower pHi, while in contralateral tissue, AACID value increases significantly by ∼4.3% compared to pre-injection, corresponding to 0.22 ± 0.19 lower pHi. Then the average AACID value returned to the baseline level in both tissues about an hour after the injection before trending back up in contralateral tissue 80 minutes and 100 minutes after injection. Control rats without tumors showed no changes following injection of cariporide in 10% or 1% DMSO. This study demonstrates the sensitivity of CEST-based pH-weighted imaging for monitoring the response of tumors to pharmacologically induced acidification. Although cariporide did induce intracellular acidification in the C6 glioma, this acidification was not tumor selective in this model.
Manual chest compression versus automated chest compression device during day-time and night-time resuscitation following out-of-hospital cardiac arrest: A retrospective historical control study
Authors: Takayama Wataru , Endo Akira , Morishita Koji , Otomo Yasuhiro 
Published: January 2023

Abstract
Background
Although the resuscitation guidelines consider mechanical chest compressions acceptable for cardiopulmonary resuscitation (CPR) in unstable settings, the efficacy of automated chest compression devices for out-of-hospital cardiac arrest (OHCA) patients according to treatment time period remains unclear. We assessed the effectiveness of automated chest compression devices depending on time of admission based on frequency of iatrogenic chest injuries, duration of in-hospital resuscitation efforts, and clinical outcomes among OHCA patients.
Methods
We conducted a retrospective historical control study of OHCA patients in Japan between April 1, 2015 and March 31, 2022. Patients were divided according to time of admission; wherein day- and night-time were considered as duration between 07:00–22:59 and 23:00–06:59, respectively. These patients were then divided into two categories based on in-hospital cardiopulmonary resuscitation (IHCPR) device used: manual chest compression (mCC) group and automatic chest compression devices (ACCD) group. Univariate and multivariate ordered logistic regression models adjusted for pre-hospital confounders were used to evaluate the impact of ACCD use during IHCPR on outcomes [IHCPR duration, CPR-related chest injuries, and clinical outcomes] in day- and night-time groups.
Results
A total of 1,101 patients with OHCA (day-time, 809; night-time, 292) formed our study population. Of these, 215 (26.6%) and 104 (35.6%) patients underwent ACCD during IHCPR in day-and night-time groups. Multivariate model showed significant association of ACCD use with outcomes of in-hospital resuscitation, including higher rates of return of spontaneous circulation, lower incidence of CPR-related chest injuries, longer in-hospital resuscitation duration, survival to Emergency Department and hospital discharge, and survival with good neurological outcome to hospital discharge, only in the night-time group.
Conclusions
Patients who underwent ACCD during in-hospital resuscitation at night had a significantly longer duration of in-hospital resuscitation, lower incidence of CPR-related chest injuries, and better outcomes.
Clinical factors associated with acute abdominal symptoms induced by gastric anisakiasis: A multicenter retrospective cohort study
Authors: Okagawa Yutaka , Sumiyoshi Tetsuya , Imagawa Takayuki , Sakano Hiroya , Tamura Fumito , Arihara Yohei , Kanari Yusuke , Sakurada Akira , Oiwa Shutaro , Jin Takashi , Tomita Yusuke , Minami Shinya , Hisai Hiroyuki , Muramatsu Hirohito , Katsuki Shinichi , Maeda Masahiro , Kondo Hitoshi 
Published: January 2023

Abstract
Background
Gastric anisakiasis typically causes severe abdominal symptoms; however, we incidentally detected asymptomatic gastric anisakiasis cases during esophagogastroduodenoscopy. The factors associated with developing acute abdominal symptoms induced by gastric anisakiasis remain unclear. Therefore, this study aimed to investigate the clinical factors associated with abdominal symptoms of gastric anisakiasis by comparing symptomatic and asymptomatic cases.
Methods
This was a retrospective cohort study involving 264 patients diagnosed with gastric anisakiasis at nine hospitals in Japan between October 2015 and October 2021. We analyzed patients’ medical records and endoscopic images and compared the clinical factors between the symptomatic and asymptomatic groups.
Results
One hundred sixty-five patients (77.8 %) were diagnosed with abdominal symptoms, whereas 47 (22.2 %) were asymptomatic. Older age, male sex, diabetes mellitus, gastric mucosal atrophy, and gastric mucosal atrophy of the Anisakis penetrating area were significantly more common in the asymptomatic group than in the symptomatic group. Multivariate analysis revealed that age (p=0.007), sex (p=0.017), and presence or absence of mucosal atrophy (p=0.033) were independent factors for the occurrence of acute abdominal symptoms. In addition, cases that were Helicobacter pylori naïve, with an elevation of white blood cells, or without an elevation of eosinophils were more common in the symptomatic group than in the asymptomatic group.
Conclusions
Age, sex, and presence or absence of gastric mucosal atrophy were the clinical factors associated with the occurrence of acute abdominal symptoms. Older and male patients and those with gastric mucosal atrophy were less likely to show abdominal symptoms. The mechanisms of the occurrence of symptoms induced by gastric anisakiasis remain unclear; however, our results will help clarify this issue in the future.
Seismic background level growth can reveal slowly developing long-term eruption precursors
Authors: Ichihara Mie , Ohminato Takao , Konstantinou Kostas , Yamakawa Kazuya , Watanabe Atsushi , Takeo Minoru 
Published: January 2023

Abstract

The accelerating growth of seismic unrest before eruptions has been observed at many volcanoes and utilized for eruption forecasts. However, there are still many eruptions for which no precursory unrest has been identified, even at well-monitored volcanoes. The recent eruptions of Shinmoe-dake, Japan, had been another negative example of this kind. Here we present seismological evidence that the eruption preparation had been ongoing at the shallow depths beneath Shinmoe-dake for several months to a year. We investigated the seismic background level (SBL) of eleven-year data recorded around the volcano, including two stations about 1 km from the eruptive crater. We searched for persistent weak signals, focusing on low-amplitude time windows recorded during quiet nighttime. Then the spectra of daily background noise were classified by clustering analysis. The SBL analysis successfully revealed very weak precursory tremors from more than several months before the eruption, and residual tremors to the end of the eruptive period. The precursory signals grew acceleratory in a similar way as is assumed in the material failure forecast method applied to eruption forecasts. However, their growth was significantly slower and longer compared to previous cases. Such slow and quiet preparations would not be captured by conventional seismological methods but could be a common feature at volcanoes with developed hydrothermal systems. We expect that long-term SBL analyses on proximal seismic data will help detect early precursors, even at seismically quiet volcanoes, and will also help judge the end of an eruptive period.
Decompositions of Infinite-Dimensional A∞,∞ Quiver Representations
Authors: Gallup Nathaniel , Sawin Stephen 
Published: January 2023

Abstract
Gabriel's Theorem states that the quivers which have finitely many isomorphism classes of indecomposable representations are exactly those with underlying graph one of the ADE Dynkin diagrams and that the indecomposables are in bijection with the positive roots of this graph. When the underlying graph is An, these indecomposable representations are thin (either 0 or 1 dimensional at every vertex) and in bijection with the connected subquivers. Using linear algebraic methods we show that every (possibly infinite-dimensional) representation of a quiver with underlying graph A∞,∞ is Krull-Schmidt, i.e. a direct sum of indecomposables, as long as the arrows in the quiver eventually point outward. We furthermore prove that these indecomposable are again thin and in bijection with both the connected subquivers and the limits of the positive roots of A∞,∞ with respect to a certain uniform topology on the root space. Finally we give an example of an A∞,∞ quiver which is not Krull-Schmidt and hence necessarily is not eventually-outward.
MSC Classification: Primary: 16G20 , 16G60 , 06A06 , 17B22 , 16D70
Assessing the impact of climatic factors on dengue fever transmission in Bangladesh
Authors: Miah Md. Mamun , Jannat Sumiya Nur , Rahman Md. Rashedur , Arafat Yasin , Pingki Farjana Haque 
Published: January 2023

Abstract

Dengue fever is a virus-borne disease spread by mosquitos, and its global prevalence has risen significantly in recent years. The aim of this study was to analyze the impact and association of climatic factors on the spread of dengue incidence in Bangladesh. From January 2011 to December 2021, the study used secondary data on monthly dengue cases and the monthly average of climatic factors. In addition to the descriptive statistics, bivariate analyses of Kendall’s tau b and Spearman’s rho have been performed for measuring the association of climatic factors on dengue infection. The multivariate generalized linear negative binomial regression model was applied to evaluate the impacts of climatic factors on dengue transmission. The model revealed that temperature (OR: 152.745,p<0.01), humidity (OR: 1.15, p<0.01), precipitation (OR: 1.131, p<0.01), wind speed (OR: 1.148, p<0.10), and air pressure (OR: 152.745, p<0.01) were significantly influenced the spread of dengue incidence in Bangladesh. The climatic season also significantly influenced dengue transmission, and a higher infection rate (OR: 140.704, p<0.01) was found in the monsoon season at August month. The findings of this study can assist policymakers and public health authorities in taking the essential steps to control the dengue infection in Bangladesh.
Modeling and simulation of cardio electrical activity for ischemia using comsol multiphysics tool
Authors: Javalkar Vinay Kumar , N Shylashree , Vahvale Yatish D , V Sridhar , C Manjunatha 
Published: January 2023

Abstract

The circulatory system revolves around the heart, which is of blood vessels network that transports blood to all part of the body. All organs of human rely on blood for transport of oxygen and some other vital nutrients, ensuring that they remain good healthy and properly function. The heart is very important for blood pumping throughout the circulatory system. When the supply of blood to tissues is restricted, oxygen lack for cellular metabolism occurs (to keep tissue alive). Ischemia is a vascular disease in which arterial blood flow is interrupted to a tissue, organ, or extremity, resulting in tissue death if left untreated. It can be caused by embolism, atherosclerotic artery thrombosis, or trauma. Acute arterial ischemia can be caused by venous issues such as venous outflow blockage and low-flow conditions. One of the most common causes of acute arterial ischemia is an aneurysm. The importance of the heart structure on COMSOL Multiphysics is highlighted as it can be modeled and simulated for cardiac contraction and relaxation. The heart cavity structure is implemented using the FHN (Fitzhugh Nagumo equation) and LG (Landau Ginzberg equation) equations along with the corner cases in this paper. The model of the heart is divided into 4 different models to demonstrate the blood flow. The changes for the 4 models are in terms of mesh and the cavity change of heart structure which indirectly demonstrates the blood movement of the heart. The observed plots are in terms of spiral waves and also the waves for the dependent variables are plotted.
Development of a Structural Model of Persistent Depressive Disorder Syndrome Based on Childhood Trauma with the Mediating Role of Cognitive, Emotional, and Interpersonal Functions
Authors: Niazifar Maedeh , Dolatshahi Behrooz , Solhi Amin , Shakiba Shima 
Published: January 2023

Abstract
Background
The relationship between childhood traumas and depression is documented, but few studies have analyzed this relationship about the severity of depression. Although several studies have illuminated the role of mediating components in this regard, these components have not been considered in a comprehensive model in the literature. Therefore, the present study aimed to develop a structural model of the severity of persistent depressive disorder symptoms according to childhood trauma and investigate the mediating role of a set of cognitive, emotional, and interpersonal functions.
Methods
This cross-sectional study utilized a structural equation structure. A total of 180 individuals consisting of patients with persistent depressive disorder, patients with episodic depressive (ED) disorder, and healthy people were selected by convenience sampling based on the eligibility criteria. Subsequently, they were assessed with the Childhood Trauma Questionnaire, BDI-II, 5 DSM- (SCID-5-RV), PHQ, DAQ, DERS-16, PII-32, and LQPT. The data were analyzed using SPSS26 and Pls3 software with structural equation modeling.
Results
The proposed model fitted the data satisfactorily. Patients with persistent depressive disorder, a more severe type of depression, had a worse condition than patients with ED and normal subjects on the components of childhood trauma, DAQ, emotional functioning, interpersonal functioning, and LQPT. Childhood trauma harmed LQPT and a positive effect on the severity of depression symptoms, depressive attributional style, and interpersonal issues. Also, childhood trauma led to more severe depression, pathological attributional styles, and interpersonal problems, and the sufferers more often engaged in preoperational thinking. Besides, the mediating role and indirect effect of emotional regulation components, interpersonal problems, and preoperational thinking were influential in the relationship between childhood trauma and the severity of depressive symptoms.
Conclusion
Childhood traumas are associated with more severe depression symptoms and more severe degradation in cognitive, interpersonal, and emotional functioning. They exert their negative effects through increasing emotional dysregulation, enhancing interpersonal problems, and engaging in preoperational thinking.
Surgical versus conservative management in the treatment of pituitary apoplexy, impact on clinical and oncological outcomes: Systematic review and meta-analysis
Authors: Arias-Angulo Juan C. , Montoya-Casella Antonio J. , Mier-García Juan F. 
Published: January 2023

Abstract
Purpose: To synthesize the evidence on the outcomes of visual function, hypopituitarism, ophthalmoplegia, and tumor growth/recurrence in patients with pituitary apoplexy (PA) treated either surgically or conservatively.
Methods: The MEDLINE, Scopus, Web of Science, Ovid, and Cochrane databases were systematically searched. The inclusion criteria were studies of adult human beings with PA, who underwent surgery or were treated conservatively for the management of their pathology and evaluated any of the described outcomes. Studies published in English and Spanish were considered, and there was no restriction regarding the date of publication. Odds ratios were estimated for each study and treatment effects were calculated through random effects models.
Results: The literature search yielded 18 studies published between 1993 and 2022, enrolling a total of 886 patients: 533 treated with surgery and 353 conservative. Patient with more severe symptoms underwent surgery. The recovery rates in visual field, endocrine function, and ophthalmoplegia, were, for overall surgery 76%, 23% and 81% respectively; early surgery 79%, 0% and 81% respectively; late surgery 73%, 0% and 70% respectively; and conservative management 79%, 23% and 90% respectively. Pooled analysis favored early surgery versus conservative management in ophthalmoplegia recovery with statistical significance OR 2.78 (CI 95% 1.09, 7.09 p = 0.03).
Conclusion: Both treatment modalities may be capable to improve or completely recover deficits in the respective appropriate cases. Further reports with greater statistical power are needed comparing equivalently treatment modalities to estimate better their effects on the studied outcomes.