bluuebunny/crossref_metadata_2025_split huggingface dataset:
In Vitro Cytostatic Effect on Tumor Cells by Carborane‐Based Dual Cyclooxygenase‐2 and 5‐Lipoxygenase Inhibitors
Authors: Braun Sebastian , Paskas Svetlana , Laube Markus , George Sven , Hofmann Bettina , Lönnecke Peter , Steinhilber Dieter , Pietzsch Jens , Mijatović Sanja S. , Maksimović‐Ivanić Danijela , Hey‐Hawkins Evamarie 
Published: December 2022

AbstractThe selective inhibition of enzymes that catalyze the conversion of arachidonic acid to inflammatory eicosanoids represents a promising approach for cancer therapy. This study, therefore, focuses on the incorporation of metabolically stable, sterically demanding, and hydrophobic carboranes into existing dual cycloxygenase‐2 (COX‐2)/5‐lipoxygenase (5‐LO) inhibitors that are key enzymes in the biosynthesis of eicosanoids. Here, the first carborane‐containing dual COX‐2/5‐LO inhibitors derived from RWJ‐63556 are presented. The replacement of the fluorophenyl moiety by meta‐ or para‐carborane resulted in five carborane‐containing derivatives 3, 6, 9, 13, and 17 that show high inhibitory activities toward COX‐2 and 5‐LO in vitro. Cell viability studies on the A375 melanoma cell line revealed that meta‐carborane derivative 3 shows higher anticancer activity compared to RWJ‐63556 based on accumulation of lipid droplets in the cells due to blockage of the COX‐2 and 5‐LO pathways, indicating a promising approach for the design of potent dual COX‐2/5‐LO inhibitors.
Osteoradionecrosis of the lamina papyracea leading to recurrent orbital infections—A case study
Authors: Chua Andy Jian Kai , Jafar Ali B. H. A. , Citardi Martin Jason 
Published: December 2022

AbstractOsteoradionecrosis (ORN) is a well‐known complication of radiotherapy (RT) to the sino‐nasal cavity and nasopharynx. Here, we report a case of recurrent orbital infections secondary to ORN of the lamina papyracea (LP). A 66‐year‐old female presented to our unit with right periorbital swelling and pain after having undergone chemotherapy and proton beam irradiation to her ethmoid sinuses for sino‐nasal undifferentiated carcinoma (SNUC) 5 years prior. She had also undergone endoscopic sinus surgery for chronic rhinosinusitis about a year prior to the current presentation. Her post‐operative course was notable for recurrent episodes of pre‐septal cellulitis occurring about 3 months apart that were increasingly severe. Examination revealed right proptosis, and endoscopy showed an exposed and denuded LP with scant crusting of the ethmoid sinuses. Microbial studies did not yield any significant growth, and imaging showed enhancement of the right orbit. The working diagnosis was acute right orbital cellulitis secondary to ORN of the right LP. She was treated with broad spectrum intravenous antibiotics and systemic steroids, but experienced minimal symptomatic improvement. She then underwent endoscopic resection of the right LP, and histopathological examination showed osteonecrosis on an inflammatory background. Post‐operatively, all orbital symptoms resolved and she was well at 6 months' follow up. In the discussion, we highlight additional factors in our patient that may have contributed to this clinical presentation, and hope that this report raises awareness of a rare complication of RT to the sino‐nasal cavity.
Synaptic resilience is associated with maintained cognition during ageing
Authors: King Declan , Holt Kris , Toombs Jamie , HE Xin , Dando Owen , Okely Judith A , Tzioras Makis , Rose Jamie , Gunn Ciaran , Correia Adele , Montero Carmen , McAlister Hannah , Tulloch Jane , Lamont Douglas , Taylor Adele M , Harris Sarah E , Redmond Paul , Cox Simon R , Henstridge Christopher M , Deary Ian J , Smith Colin , Spires‐Jones Tara L 
Published: December 2022

AbstractIntroductionIt remains unclear why age increases risk of Alzheimer's disease and why some people experience age‐related cognitive decline in the absence of dementia. Here we test the hypothesis that resilience to molecular changes in synapses contribute to healthy cognitive ageing.MethodsWe examined post‐mortem brain tissue from people in mid‐life (n = 15), healthy ageing with either maintained cognition (n = 9) or lifetime cognitive decline (n = 8), and Alzheimer's disease (n = 13). Synapses were examined with high resolution imaging, proteomics, and RNA sequencing. Stem cell‐derived neurons were challenged with Alzheimer's brain homogenate.ResultsSynaptic pathology increased, and expression of genes involved in synaptic signaling decreased between mid‐life, healthy ageing and Alzheimer's. In contrast, brain tissue and neurons from people with maintained cognition during ageing exhibited decreases in synaptic signaling genes compared to people with cognitive decline.DiscussionEfficient synaptic networks without pathological protein accumulation may contribute to maintained cognition during ageing.
Phenoxazine Polymer‐based p‐type Positive Electrode for Aluminum‐ion Batteries with Ultra‐long Cycle Life
Authors: Yang Zhaohui , Huang Xiaobing , Meng Pengyu , Jiang Min , Wang Yibo , Yao Zhenpeng , Zhang Jiao , Sun Baode , Fu Chaopeng 
Published: December 2022

AbstractAluminum‐ion batteries (AIBs) are a promising candidate for large‐scale energy storage due to the abundant reserves, low cost, good safety, and high theoretical capacity of Al. However, AIBs with inorganic positive electrodes still suffer from sluggish kinetics and structural collapse upon cycling. Herein, we propose a novel p‐type poly(vinylbenzyl‐N‐phenoxazine) (PVBPX) positive electrode for AIBs. The dual active sites enable PVBPX to deliver a high capacity of 133 mAh g−1 at 0.2 A g−1. More impressively, the expanded π‐conjugated construction, insolubility, and anionic redox chemistry without bond rearrangement of PVBPX for AIBs contribute to an amazing ultra‐long lifetime of 50000 cycles. The charge storage mechanism is that the AlCl4− ions can reversibly coordinate/dissociate with the N and O sites in PVBPX sequentially, which is evidenced by both experimental and theoretical results. These findings establish a foundation to advance organic AIBs for large‐scale energy storage.
Long‐Term Stability Challenges and Opportunities in Acidic Oxygen Evolution Electrocatalysis
Authors: Wang Qilun , Cheng Yaqi , Tao Hua Bing , Liu Yuhang , Ma Xuehu , Li Dong‐Sheng , Yang Hong Bin , Liu Bin 
Published: December 2022

AbstractPolymer electrolyte membrane water electrolysis (PEMWE) has been regarded as a promising technology for renewable hydrogen production. However, acidic oxygen evolution reaction (OER) catalysts with long‐term stability impose a grand challenge in its large‐scale industrialization. In this review, critical factors that may lead to catalyst's instability in couple with potential solutions are comprehensively discussed, including mechanical peeling, substrate corrosion, active‐site over‐oxidation/dissolution, reconstruction, oxide crystal structure collapse through the lattice oxygen‐participated reaction pathway, etc. Last but not least, personal prospects are provided in terms of rigorous stability evaluation criteria, in situ/operando characterizations, economic feasibility and practical electrolyzer consideration, highlighting the ternary relationship of structure evolution, industrial‐relevant activity and stability to serve as a roadmap towards the ultimate application of PEMWE.
Investigating the synthesized sodium gluconate‐loaded chitosan microspheres on mild steel corrosion inhibition in acidic medium
Authors: Li Jiansan , Zhang Wenjing 
Published: December 2022

In this research, the sodium gluconate‐loaded chitosan microspheres (SG/CM) are prepared by negative pressure impregnation after chitosan (CS) hydrothermally synthesized with vanillin (VA) to form chitosan microspheres (CM), which is in shape of ellipsoidal spheroid. The structures of the prepared micron materials are investigated by Fourier transform infrared spectroscopy (FTIR), while tungsten filament scanning electron microscopy (SEM) and transmission electron microscopy (TEM) are used to characterize the morphology of the prepared. Moreover, the thermogravimetric characterization reveals that loading sodium gluconate made it more thermally stable. The corrosion inhibition performance of CS, CM, and SG/CM is investigated in 0.1 mol/L HCl by electrochemical impedance spectroscopy (EIS), indicating an increase efficiency for inhibitors at higher concentrations, and the optimum is achieved by SG/CM at 200 mg/L, corresponding to weight loss measurements. The potentiodynamic polarization (PDP) test shows the best inhibition efficiency, 92.01% for SG/CM, which is superior to 52.23% for CS and 75.91% for CM. The surface features of corroded samples are investigated by Leica optical microscopy. Additionally, the inhibition mechanism of SG/CM is studied by building the Langmuir adsorption model, revealing that the inhibitory molecule occupies only one site on the themetallic surface.
Influence of processing conditions on the evolution of morphology in PVDF/PS and PP/PS polymer blends: Examining the processing‐phase inversion mechanism
Authors: Ramakrishnan Shashank , Lencar Calin , Sundararaj Uttandaraman 
Published: December 2022

AbstractUnderstanding morphological changes in polymer blends in the initial melting region of an extruder is crucial for optimizing the polymer mixing process. In blends with a large difference in their softening temperatures, a processing‐phase inversion transition occurs when a larger volume‐fraction of the higher melting component is present. The morphological changes in 80/20 PVDF/PS blends were examined (where PVDF forms the major phase) in an internal mixer under different processing conditions, such as preset temperature program, fill volume and rotor speed. We studied the torque behavior, energy consumption during mixing and phase inversion point for both 80/20 PVDF/PS and 80/20 PP/PS blends. PP needed 2.4 times higher mechanical energy to be deformed and to achieve a similar phase inverted state, compared to PVDF. To examine the effect of the minor phase properties, two 80/20 PVDF/minor ph.ase systems were examined: (i) a low‐melting viscous EVA (ethylene vinyl acetate copolymer), and (ii) a low viscosity PCL (polycaprolactone). Using a range of techniques, such as torque monitoring, optical microscopy, SEM etc., it is established that the nature of the minor phase (amorphous vs. semicrystalline), minor phase melt viscosity and the exact processing parameters influence the point at which the phase inversion occurs.
Selective Production of 1,2‐Propanediol or 1,3‐Propanediol from Glycerol Hydrogenolysis over Transition Metal Doped Pt/TiO2
Authors: Luo Zhicheng , Zhu Zhiguo , Xiao Rui , Chu Dawang 
Published: December 2022

AbstractSelective hydrogenolysis of biomass‐derived glycerol to propanediol is important for producing high value‐added chemicals from renewable resources but faces a huge challenge. Here we report a transition metal doped Pt/TiO2 catalyst with incorporated Cr, Mo, or W oxides, which exhibits the selective formation of 1,2‐propanediol or 1,3‐propanediol with a yield from 51.2% to 82.5% toward glycerol hydrogenolysis. In situ experimental studies verify that the surrounding CrOx decreases the hydrogenating ability of Pt, leading to the formation of 1,2‐propanediol, while the MoOx or WOx brings the Brønsted acid, giving 1,3‐propanediol. This modification based on the catalyst compositions alters the reaction pathway with a different adsorption and bond scission mechanism, which can be extended to other sustainable catalytic systems.
Solvent‐Controlled Photoswitching of Azobenzene: An Excited State Shuttle
Authors: Raman Arunachalam , Neelambra Afeefah U. , Karunakaran Venugopal , Easwaramoorthi Shanmugam 
Published: December 2022

AbstractThe light‐controlled excited state trans‐cis isomerization process is a key to the development of conversion of light energy to mechanical motion at the molecular level. Considerable efforts have been made in tuning the isomerization process with electron donor and acceptor substituents by altering the excited state reaction coordinate. Here, we report a two novel push‐pull series of para‐diethylamino (DEA) and diphenylamino (DPA) substituted (E)‐4′‐((4‐(diethylamino)phenyl)diazenyl)‐N,N‐diphenyl‐[1,1′‐biphenyl]‐4‐amine (1) and (E)‐4′‐((4‐(diphenylamino)phenyl)diazenyl)‐N,N‐diphenyl‐[1,1′‐biphenyl]‐4‐amine (2). Compounds 1 and 2 undergo both photochemical and photophysical excited state deactivation pathways which can be controlled by varying the solvent polarity. These structural motifs of 1 and 2 would undergo torsional motions upon excitation to exhibit either trans→cis photoisomerization or to form a twisted intramolecular charge transfer state and both the process originates from the same excited state and competes with each other. Thus, alternations in the surrounding environment such as solvent polarity, solution viscosity, and protonation were employed to understand the preferential excited state deactivation pathway and thereby these systems could be employed as a new class of azobenzene‐based luminescent photochromic molecules. For instance, in nonpolar solvent, toluene photoisomerization is preferred over TICT, but polar solvent, ethanol preferentially stabilizes the TICT state by virtue of N−C rotation which renders the energy barrier unfavourable for photoisomerization. The photostationary state of 1 in toluene is predominantly the Z isomer, whereas in ethanol E isomer is nearly two‐fold higher than the Z isomer. These feature sets up a new approach towards the construction of multinary molecular switches and subsequent development in diverse fields.
Erfahrungen im Rückbau von Spannbetonbrücken unter Einsatz von Vorschubrüstungen
Authors: Däbrit Michael , Buchmann Boris , Lang Matthias , Wagner Peter 
Published: December 2022

AbstractDer Rückbau vorgespannter massiver Talbrücken auf einer Vorschubrüstung ist ein etabliertes Verfahren, wo konventioneller und sprengtechnischer Rückbau nicht angewendet werden kann. Im Erfahrungsbericht werden die Komponenten der Rückbaugerüste beschrieben, Besonderheiten dieser Rückbaumethode und Randbedingungen für den Einsatz von Vorschubrüstungen entgegen und in Herstellrichtung des abzubrechenden Bauwerks benannt sowie die Möglichkeit der Wiederverwendung der Vorschubrüstung für den Ersatzneubau. Schnittstellen zum Bauwerk werden definiert und Hinweise zur Planung derartiger Rückbauprojekte werden gegeben. Anhand des Beispiels Talbrücke Onsbach erfolgt eine Ablaufbeschreibung des Rückbauverfahrens.
Comparison of external system and implanted system in intrathecal therapy for refractory cancer pain in China: A retrospective study
Authors: Qin Wangjun , Zhao Li , Liu Botao , Yang Yang , Mao Peng , Xu Liyuan , Li Pengmei , Shang Yongguang , Zhang Lei , Fan Bifa 
Published: December 2022

AbstractIntroductionIntrathecal therapy (ITT) via an implanted system was demonstrated for the treatment of refractory cancer pain for decades. Recently, the dissemination of ITT is enhanced in an external system way in Asia for a lower implantation cost. This study compares the efficacy, safety, and cost of the two ITT systems in refractory cancer pain patients in China.MethodsOne hundred and thirty‐nine cancer pain patients who underwent implantation of the ITT system were included. One hundred and three patients received ITT via the external system (external group), while 36 patients received ITT via the implanted system (implanted group). A 1:2 propensity score matching procedure was used to yield a total of 89 patients for the final analysis. Medical records of included patients were retrospectively reviewed and pain scores, incidences of complications, and costs were compared.ResultsITT via the external system provided pain relief as potent as ITT via the implanted system but was less time‐consuming in the implantation phase (13 vs. 19 days,p < .01). Nausea/vomiting and urinary retention were the most frequent adverse events in both external and implanted groups (32.14%, 16.07% vs. 36.36%, 21.21%). No significant difference was found in the incidences of all kinds of complications. Compared to the implanted group, the external group cost less for the initial implantation (7268 vs. 26,275 US dollar [USD],p < .001) but had a significant higher maintenance cost (606.62 vs. 20.23 USD calculated monthly,p < .001).ConclusionsITT via the external system is as effective and safe as that via the implanted system and has the advantage of being cheap in the upfront implantation but costs more during the maintenance process in China.
A genetic off‐target event in a site‐specific integration cell line expressing monoclonal antibody has no impact on commercial suitability
Authors: Tevelev Barbara , Chambers Andre , Ghosh Swap , Zhang Ying , Marzili Lisa , Rouse Jason C. , Han Shu , Moffat Mark , Scarcelli John J. 
Published: December 2022

AbstractSite‐specific integration (SSI) cell line systems are gaining popularity for biotherapeutic development and production. Despite the proven advantages for these expression hosts, the SSI system is still susceptible to rare off‐target events and potential vector rearrangements. Here we describe the development process of an SSI cell line for production of an IgG1 monoclonal antibody (mAb‐086). During cell line generational studies to assess suitability of clone C10 for commercial purposes, restriction fragment lengths of genomic DNA harboring the light chain (LC) were not in agreement with the predicted size. We first confirmed that the SSI landing‐pad achieved occupancy of the desired expression plasmid. Additional investigation revealed that random integration had occurred, resulting in the acquisition of a partial copy of the LC and a full‐length copy of the heavy chain (HC) at a different locus in the host genome. This off‐target event had no impact on the genotypic consistency and phenotypic stability of the cell line, the production process, or the drug substance product quality. Given the genetic, phenotypic, and process consistency of the cell line, clone C10 was deemed suitable as a manufacturing cell line.
Genetic testing women with newly diagnosed breast cancer: What criteria are the most predictive of a positive test?
Authors: Metcalfe Kelly A. , Narod Steven A. , Eisen Andrea , Poll Aletta , Zamani Neda , McCready David , Cil Tulin D. , Wright Frances C. , Lerner‐Ellis Jordan , McCuaig Jeanna , Graham Tracy , Sun Ping , Akbari Mohammad R. 
Published: December 2022

AbstractBackgroundKnowledge of pathogenic variants in cancer‐predisposing genes is important when making breast cancer treatment decisions, but genetic testing is not universal and criteria must be met to qualify for genetic testing. The objective of this study was to evaluate the pathogenic variant yield for nine cancer predisposition genes by testing criteria, singly and in combination.MethodsWomen diagnosed with breast cancer between June 2013 and May 2018 were recruited from four centers in Toronto, Canada. Participants completed a demographics and family history questionnaire and clinical characteristics were collected from medical charts. Genetic testing was done for BRCA1, BRCA2, PALB2, ATM, CHEK2, BRIP1, RAD51D, RECQL, and TP53. Pathogenic variant frequencies were calculated according to five criteria (age ≤ 50, triple‐negative breast cancer, family history, bilateral breast cancer, or Jewish ethnicity).ResultsOf the 1006 women studied, 100 women (9.9%) were found to have a pathogenic variant in one of the nine genes tested. The highest prevalence of pathogenic variants was found in women with triple‐negative breast cancer (23%). Of the 100 pathogenic variants detected, 78 were detected in women diagnosed at age 50 or less. A total of 96% of the mutations were identified with three criteria (age of diagnosis, family history, and triple‐negative status).ConclusionsGenetic testing criteria for women with breast cancer should include women with triple‐negative breast cancer, regardless of age. All women aged 50 years or below at time of breast cancer diagnosis should be offered genetic testing.
Upregulation of Tim‐3 is associated with poor prognosis in acute myeloid leukemia
Authors: Wu Zhengwei , Ou Jiawang , Liu Nannan , Wang Zhixiang , Chen Junjie , Cai Zihong , Liu Xiaoli , Yu Xiao , Dai Min , Zhou Hongsheng 
Published: December 2022

AbstractAcute myeloid leukemia (AML) is a heterogeneous hematopoietic malignancy originated from leukemia stem cells (LSC). Emerging evidence suggests T‐cell immunoglobulin mucin‐3(Tim3) as surface marker for LSC. However, the clinical significance and biology of Tim‐3 in AML remain to be determined, especially those LSCs. In public AML databases as well as our data, we separated AML patients into Tim‐3high and Tim‐3low subsets using the X‐tile software and evaluated the associations between Tim‐3 and overall survival (OS) and disease‐free survival (DFS). The Cancer Genome Atlas (TCGA) cohort revealed that high Tim‐3 expression in leukemic cells was linked with poor prognosis (DFS: p = 0.018; OS: p = 0.041). Furthermore, multiple regression analysis shows that Tim‐3 was an independent factor for the prognosis (HR = 2.26, 95% CI = 1.15–4.44, p = 0.017). Validation cohort of public gene expression omnibus (GEO) confirmed that Tim‐3 was a prognostic candidate in AML. Besides, in our internal cohort, we also confirmed that over expression of Tim‐3 protein in LSC/LPC made poor prognosis in AML. Additionally, we revealed that the LSC markers AKR1C3, CD34, and MMRN1 were upregulated in the Tim‐3high group of TCGA. We found that the upregulated genes in the Tim‐3high group were mainly enriched in immune response, cytokine binding and cell adhesion molecules, and JAK–STAT signaling pathway, by gene ontology (GO) enrichment analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis. Collectively, we revealed that, for the first time, upregulation of Tim‐3 in LSCs at the level of gene and protein expression is associated with poor prognosis and the important biological feature of Tim‐3 of LSC in AML.
Rifampin‐induced acute kidney injury and hemolysis: A case report and literature review of a rare condition
Authors: Ata Fateen , Magboul Hiba M. B. , Toba Haneen A. A. , Alfar Hadeel , Al Bozom Adel , Murshed Khaled , Zahid Muhammad 
Published: December 2022

AbstractRifampicin is a bactericidal drug used in various infectious diseases, including tuberculosis (TB). Nephrotoxicity is a rare side effect of intermittent Rifampin use and even less commonly continued use. We report a case of Rifampin‐induced acute tubular necrosis and hemolysis in a patient with latent TB with a relevant literature review.
Henry gas bird swarm optimization algorithm‐based deep learning for brain tumor classification using magnetic resonance imaging
Authors: Ponnupilla Omana Sinciya , Dar Jawad Ahmad , Rajesh Kumar Thevasigamani , Sampath Arpakkam Karuppan , Sharma Sudhir 
Published: December 2022

SummaryIn order to categorize brain tumors, this study uses a deep convolutional neural network (DCNN) based on Henry gas bird swarm optimization (HGBSO). The Henry gas solubility optimization (HGSO) and bird swarm algorithm techniques were merged to form the HGBSO algorithm, which was used to train the DCNN classifier. Following the first preprocessing of the images using the Gaussian filter, the Region of Interest extraction approach is utilized to reduce noise from the input MR images. After that, the regions of brain tumors are divided using a deep fuzzy clustering technique. Meanwhile, key characteristics are taken from the segmented image in order to perform an efficient classification procedure. Moreover, for improving the classification accuracy rate, data augmentation is performed. Finally, the augmented data along with total features are considered as input for developed HGBSO trained DCNN classifier, where the classification of brain tumor is performed. In terms of various metrics, the developed strategy performs better than other existing methods, obtaining values of 0.9221 for accuracy, 0.9324 for sensitivity, and 0.9295 for specificity.