bluuebunny/crossref_metadata_2025_split huggingface dataset:
Obstetric pain management for pregnant women with opioid use disorder: A qualitative and quantitative comparison of patient and provider perspectives (QUEST study)
Authors: Nowakowski Emma , Dayananda Sanjana , Morgan Madison , Jarvis Olivia , Altamirano Valeria , LaSorda Kelsea R. , Krans Elizabeth , Lim Grace 
Published: January 2023

AbstractBackground and aimPatients with opioid use disorder (OUD) may experience inadequate pain management especially during childbirth. This study assessed and compared patient and provider perspectives on analgesia during and after delivery in women with OUD.DesignProspective cohort, mixed method design including semi‐structured interviews and structured surveys with pregnant or recently pregnant patients (n = 17) and provider (n = 15) groups.SettingPrenatal clinics and hospital postpartum units.ParticipantsPatients were pregnant women with OUD currently treated with methadone (n = 1) or buprenorphine (n = 16). Providers were obstetricians (n = 5), obstetric nurses (n = 5) and anesthesiologists (n = 5).MeasurementsValidated questionnaires were completed by both groups; patient interviews were conducted during the third trimester and at 5 days post‐delivery. Patient topics included pain management preferences, analgesia satisfaction and attitudes toward pain. Provider topics included labor and postpartum pain management perspectives. Interviews were independently coded and qualitatively analyzed for major themes.FindingsFive major themes emerged from patient interviews: (1) neuraxial blockade was endorsed for labor pain; (2) otherwise, limited pain control options were perceived; (3) no consensus around use of opioids for pain; (4) non‐opioid options should be available; and (5) provider communication and health‐care system issues act as barriers to adequate pain management. Provider perspective themes included the following: (1) unique challenges in pain management for patients with OUD; (2) confusion on how to plan for and make perinatal adjustments to medication for OUD; (3) discrepant views on use of opioids for pain management; (4) endorsement of non‐pharmacological and non‐opioid options; and (5) need for improved provider collaboration in developing pain management plans.ConclusionsPatients with opioid use disorder and health‐care providers prioritize pain management during and after childbirth, but have discrepant views on use of opioids and other pain management options. Inadequate care coordination and discrepancies in opinions need to be addressed both within care teams and between patients and providers. Clinicians would benefit from better evidence to guide clinical care of patients with OUD for patient‐centered pain management.
Selective internal radiation therapy with yttrium‐90 resin microspheres followed by anatomical hepatectomy: A potential curative strategy in advanced hepatocellular carcinoma
Authors: Feng Xiaobin , Zhang Lin , Niu Huimin , Zhang Hui , Yang Li , Wen Yong , Chen Steve Y. , Shi Yuhong , He Zuoxiang , Yu Lijuan , Wang Yujun , Huang Xin , Wang Zhiheng , Qin Mengmeng , Wen Xiaoxi , Zhang Zhenyu , Song Jiyong , Zheng Zhuozhao , Yin Hongfang , Zhang Huan , Ma Lijuan , Wei Jixiang , Wu Xinlai , Zhang Leida , Zhao Yue , Lu Qian , Xiao Hui , Liu Tongting , Fang Pihua , Wei Lai , Gandhi Ripal T. , Dong Jiahong 
Published: January 2023

AbstractAbout 80% of hepatocellular carcinoma (HCC) patients are in advanced stages and ineligible for curative surgery. Palliative treatments just maintained limited survival, thus an effective downstaging therapy is badly needed. Here we report an initially unresectable patient who underwent radical hepatectomy after successful downstaging with selective internal radiation therapy (SIRT). A 34‐year‐old man was diagnosed with China Liver Cancer Staging (CNLC) IIIa HCC. Due to insufficient future liver remnant and vascular involvement, the patient was suggested to be unresectable. SIRT with yttrium‐90 resin microspheres was given. At three months post‐SIRT, a complete response was achieved. The tumor was downstaged to CNLC Ia stage. The patient underwent anatomical hepatectomy 5 months after SIRT. Histopathological examination of the resected specimen showed 4% viable tumor cells inside a necrotic mass. To our knowledge, this is the first case who underwent SIRT with yttrium‐90 resin microspheres in China mainland. The success of the downstaging in this case renders a possible cure to be achieved in an initially unresectable patient. In addition, the nearly complete tumor necrosis in the resected specimen indicates a good prognosis post‐surgery. This is the first case who underwent SIRT with yttrium‐90 resin microspheres in China mainland. SIRT followed by anatomical hepatectomy is a potentially curative strategy for unresectable HCC, which deserves a confirmative trial in the future.
Construction and validation of a novel tumor necrosis factor‐related apoptosis‐inducing ligand mutant MuR5S4‐TR
Authors: Zhao Yaqin , He Jianping , Liu Xia , Yi Cheng , Sun Lei , Zhu Hong 
Published: January 2023

AbstractAimTumor necrosis factor‐related apoptosis‐inducing ligand (TRAIL) can selectively kill tumor cells but has no significant effect on normal cells. However, the use of TRAIL is limited for resistance by more than 50% of the tumor cell lines. It's very important to develop a more efficient form of TRAIL for cancer treatment.MethodsThe N‐terminal in soluble fragments (114–281aa) of TRAIL was redesigned to construct a novel TRAIL mutant‐MuR5S4‐TR. The Cell Counting Kit‐8 method to explore the antitumor effects. The potential mechanisms were also explored.ResultsNovel TRAIL mutant with cell‐penetrating peptides (CPP) like and Second mitochondria‐derived activator of caspases (Smac) like structure‐MuR5S4‐TR was successfully constructed. The prokaryotic expression system was successfully built, and the MuR5S4‐TR was purified and reconfirmed by western blot. MuR5S4‐TR could enhance the antitumor effects of TRAIL in most of the cancer cell lines significantly, NCI‐H460 lung cancer cell line, for instance. After MuR5S4‐TR treatment, the expressions of death receptor 4 (DR4), DR5, Caspase‐8, and cleaved Caspase‐3 were remarkably increased, however, there was no significant difference in X‐linked inhibitor of apoptosis expression.ConclusionWe constructed a novel TRAIL mutant with CPP‐like and Smac‐like structure‐MuR5S4‐TR. The MuR5S4‐TR showed significantly stronger antitumor effects than TRAIL in many tumor cell lines. The MuR5S4‐TR showed strong antitumor effects both in vitro and in vivo. This preliminary study implies that MuR5S4‐TR may be a more efficient form of TRAIL for cancer therapy.
Use of analgesics in Denmark: A national survey
Authors: Burghle Alaa , Pottegård Anton , Rasmussen Malthe , Bruun Belinda , Roost Hosbjerg Jens , Lundby Carina 
Published: January 2023

AbstractPeople suffering from pain constitute a sizeable and heterogeneous patient group. Conventional oral analgesics are considered a cheap and safe first‐line treatment. These drugs are used on both a regular and ‘as needed’ basis and are often obtained over‐the‐counter (OTC). We explored patient‐reported patterns of use and adverse effects of analgesics in a community pharmacy questionnaire. Eight pharmacies invited persons aged ≥18 years requesting analgesics via prescription or OTC to complete an electronic questionnaire. A total of 2410 participants completed the questionnaire (68% female; 50% ≥ 60 years). Most participants filled a prescription for paracetamol (61%; n = 842) and non‐steroidal analgesics (n = 363; 26%). Among OTC users, most obtained paracetamol (61%). Among prescription users, 73% (n = 1114) had their analgesic prescribed for daily use; however, of these only 61% (n = 630) reported using it daily, while 35% (n = 363) reported ‘as needed’ use. Of all prescriptions, 80% (n = 898) were labelled with the standardized indication ‘against pain’. Self‐reported indications showed that back pain and muscle/joint pain were the most common indications. Among non‐new users of OTC analgesics (n = 841), 17% (n = 141) used their medication daily. Finally, 90% (n = 1658) of all participants reported not experiencing adverse effects. Our findings suggest a need for continuous assessment of analgesic patterns of use after treatment initiation to inform counselling in community pharmacies and elsewhere.
Discovery of alantolactone as a naturally occurring NLRP3 inhibitor to alleviate NLRP3‐driven inflammatory diseases in mice
Authors: Li Weifeng , Xu Haowen , Shao Jingjing , Chen Jiahao , Lin Yimin , Zheng Zhiwei , Wang Yi , Luo Wu , Liang Guang 
Published: January 2023

Background and PurposeThe NLR family pyrin domain‐containing 3 (NLRP3) inflammasome is activated in many inflammatory conditions. So far, no low MW compounds inhibiting NLRP3 have entered clinical use. Identification of naturally occurring NLRP3 inhibitors may be beneficial to the design and development of compounds targeting NLRP3. Alantolactone is a phytochemical from a traditional Chinese medicinal plant with anti‐inflammatory activity, but its precise target remains unclear.Experimental ApproachA bank of phytochemicals was screened for inhibitors of NLRP3‐driven production of IL‐1β in cultures of bone‐marrow‐derived macrophages from female C57BL/6 mice. Models of gouty arthritis and acute lung injury in male C57BL/6J mice were used to determine the in vivo effects of the most potent compound.Key ResultsAmong the 150 compounds screened in vitro, alantolactone exhibited the highest inhibitory activity against LPS + ATP‐induced production of IL‐1β in macrophages, suppressing IL‐1β secretion, caspase‐1 activation and pyroptosis. Alantolactone directly bound to the NACHT domain of NLRP3 to inhibit activation and assembly of NLRP3 inflammasomes. Molecular simulation analysis suggested that Arg335 in NLRP3 was a critical residue for alantolactone binding, leading to suppression of NLRP3–NEK7 interaction. In vivo studies confirmed significant alleviation by alantolactone of two NLRP3‐driven inflammatory conditions, acute lung injury and gouty arthritis.Conclusion and ImplicationsThe phytochemical alantolactone inhibited activity of NLRP3 inflammasomes by directly targeting the NACHT domain of NLRP3. Alantolactone shows great potential in the treatment of NLRP3‐driven diseases and could lead to the development of novel NLRP3 inhibitors.
Opportunities and challenges for Common Agricultural Policy reform to support the European Green Deal
Authors: Cuadros‐Casanova Ivon , Cristiano Andrea , Biancolini Dino , Cimatti Marta , Sessa Andrea Antonio , Mendez Angarita Valeria Yeraldin , Dragonetti Chiara , Pacifici Michela , Rondinini Carlo , Di Marco Moreno 
Published: January 2023

AbstractThe Common Agricultural Policy (CAP) is the European Union's main instrument for agricultural planning, with a new reform approved for 2023–2027. The CAP intends to align with the European Green Deal (EGD), a set of policy initiatives underpinning sustainable development and climate neutrality in the European Union (EU), but several flaws cast doubts about the compatibility of the objectives of these 2 policies. We reviewed recent literature on the potential of CAP environmental objectives for integration with the EGD: protection of biodiversity, climate change mitigation and adaptation, and sustainable management of natural resources. The CAP lacks appropriate planning measures, furthering instead risks to biodiversity and ecosystem services driven by landscape and biotic homogenization. Funding allocation mechanisms are not tailored to mitigate agricultural emissions, decreasing the efficiency of climate mitigation actions. The legislation subsidies farmers making extensive use of synthetic inputs without adequately supporting organic production, hindering the transition toward sustainable practices. We recommend proper control mechanisms be introduced in CAP Strategic Plans from each member state to ensure the EU is set on a sustainable production and consumption path. These include proportional assignment of funds to each CAP objective, quantitative targets to set goals and evidence‐based interventions, and relevant indicators to facilitate effective monitoring of environmental performance. Both the CAP and the EGD should maintain ambitious environmental commitments in the face of crisis to avoid further degradation of the natural resources on which production systems stand.
Thromboembolic complications of Mycoplasma pneumoniae pneumonia in children
Authors: Chen Lanqin , Yin Ju , Liu Xiuyun , Liu Jun , Xu Baoping , Shen Kunling 
Published: January 2023

AbstractBackgroundThromboembolism is less common in children than in adults, but it is frequently associated with Mycoplasma pneumoniae infection in many cases. This study aimed to investigate the clinical characteristics of pediatric M. pneumoniae pneumonia complicated with thromboembolism.MethodsHospitalized patients with M. pneumoniae pneumonia complicated by thromboembolism were enrolled from January 2012 to December 2021 in Beijing Children's Hospital, Capital Medical University, China. The data on clinical manifestations, laboratory tests, and treatment were evaluated.ResultsA total of 49 cases were enrolled, with a mean age of 7.9 years old, including 27 boys and 22 girls. Consolidation of pulmonary lobe or segment was observed in 95.9% (47/49) of the cases, whereas interstitial change was found only in two patients; 85.7% (42/49) of patients had pleural effusion. Pulmonary vascular thromboembolism was most common in 35 patients, whereas 13 cases had thromboembolism of multiple anatomic sites. The levels of C‐reaction protein, lactate dehydrogenase, and erythrocyte sedimentation rate were all increased, with a mean value of 54.08 ± 52.27 g/L, 451.12 ± 218.76 U/L, 43.40 ± 29.43 mm/h, respectively. Blood coagulation test showed that all 49 patients had elevated D‐dimer values (median 3.81 ng/ml, range, 0.34–48 ng/ml) and normal PT. aPTT.LA was positive in 74.3% (26/35) of the cases. aCL‐IgM was positive in 66.7% (26/39) of the cases. aβ2GPI‐IgM was positive in 79.4% (27/34) of the cases. The prognosis was generally good in this group.ConclusionPulmonary arteriovenous thromboembolism is the most common thromboembolism complicated in MPP, and cerebral artery embolism and cardiac thrombosis are common in extrapulmonary thromboembolism. In the cases of MPP with thromboembolic complications, pulmonary consolidation with pleural effusion is the main characteristic. About two thirds of the cases are positive for antiphospholipid antibodies.
Five Stylized Facts on Belt and Road Countries and Their Trade Patterns
Authors: Damoah Kaku Attah , Giovannetti Giorgia , Marvasi Enrico 
Published: January 2023

AbstractThe Belt and Road Initiative (BRI) offers investment opportunities for several Eurasian countries but not all of them attract investments in the same way. This paper investigates the geographical distribution of BRI projects completed between 2013 and 2020. The analysis shows that pre‐existing trade patterns are related to the likelihood of a country receiving completed BRI projects. We single out and provide evidence in support of five stylized facts. First, BRI countries with completed projects tend to be poorer and larger. Second, projects are more likely to occur in countries with intense intermediate trade with China. Third, the countries that received projects have more diversified export structures and their sectoral specialization overlaps with that of China. Fourth, among middle‐high‐income countries, the allocation of projects tends to favor those with high levels of intra‐industry trade. Fifth, among BRI countries with projects, the complexity or sophistication of the goods traded increases faster with income. These findings suggest that fostering trade integration has direct benefits and may also contribute to further BRI investments.
Methodological Reflections on Normative Case Studies: What They are and Why We Need Better Quality Criteria to Inform Their Use
Authors: Taylor Rebecca M. 
Published: January 2023

AbstractNormative case studies represent empirically grounded phenomena that raise normative philosophical questions. Growth in the popularity of case‐based inquiry in philosophy reflects a recent trend in the field not to shy away from engaging with empirical realities, but instead to advance philosophical projects that recognize and speak directly to these realities, including social inequities endemic to our societies. Yet, as the use of case studies and other empirically engaged philosophical approaches has grown, concerns have been raised about whether these methods risk reducing philosophy to social science and, in turn, burdening philosophy with the constraints of social science research. Responding to these concerns calls for more attention to the methodological dimensions of case‐based inquiry in philosophy. In this article, Rebecca Taylor offers reflections on two core clarifying questions: (1) What makes normative case studies distinct from other related tools for inquiry — in particular, philosophical thought experiments and qualitative case studies? (2) What quality criteria should guide the development of normative case studies?
“Like stepping on glass”: A theoretical model to understand the emotional experience of childhood parentification
Authors: Schorr Shirley , Goldner Limor 
Published: January 2023

AbstractObjectiveThis purpose of this article is to contribute to the literature on the lived experiences of parentification, its long‐term consequences to the self, and coping strategies related to parentification.BackgroundA considerable number of quantitative studies have reported on the adverse consequences of destructive or pathological parentification.MethodNineteen Israeli women aged 30–68 years who believed that they had experienced parentification during childhood and adolescence took part. The women participated in in‐depth semistructured interviews. The data analysis employed the constructivist grounded theory approach.ResultsThe participants described their childhood and adolescence as a horrifying, threatening, invasive, and neglectful experience that demanded constant adaptation to cope with the anxiety and fear of breakdown. A developmental relational trauma model is proposed to account for the relationships described in their responses. Drawing on convergent findings from psychoanalytic and developmental approaches, the model suggests that the participants developed a split self‐structure to cope with these adverse experiences. It is argued that creating a split disconnecting the topographic structure of the self is key to understanding the sources of role reversal. By aiming to overcome the overwhelming experience of abuse and neglect, this split structure paradoxically protects the traumatized participants from the fragmentation of the self through multiple disconnections.ConclusionsParentification can be considered a form of emotional abuse and neglect.ImplicationsClinicians need to recognize the destructive effects of this relationship on self‐structuring.
Using pre‐gelatinised red lentils in pasta production: connecting starch features and pasta cooking behaviour
Authors: Bresciani Andrea , Giuberti Gianluca , Cervini Mariasole , Marti Alessandra 
Published: January 2023

SummaryConsidering the high interest in using pulses in the production of staple foods, including pasta, this study aimed at investigating the effect of pre‐gelatinisation on the overall quality of pasta from red lentils. Pre‐gelatinized flours showed a lower gelatinisation temperature (up to about 57 °C vs. about 65 °C) and higher retrogradation tendency than native flour. Such changes resulted in higher water absorption capacity (up to 1.23 vs. 0.98 g g−1) and higher farinographic torque, but did not impact the cooking quality. Conversely, the resistant starch content of cooked pasta decreased (from 14.79 to 10.4 g/100 g total starch) and the starch hydrolysis index increased (from 48.28 to 67.71) when pre‐gelatinised flours were used. In conclusion, pre‐gelatinisation impacted starch, hydration and the mixing properties of red lentils flours, without compromising the cooking behaviour of the related pasta.
Associations between interleukin 17A and 17F polymorphisms and asthma susceptibility: A meta‐analysis
Authors: Lee Young Ho , Song Gwan Gyu 
Published: January 2023

AbstractOwing to their role in inflammatory reactions and immunological responses as well as their chromosomal location, interleukin (IL) 17A and 17F are regarded as candidate causal genes associated with asthma. The aim of this study was to determine whether IL17 polymorphisms are associated with susceptibility to asthma. We used the PubMed/Medline and Embase databases to search for studies reporting IL17 polymorphisms in patients with asthma and healthy controls. Meta‐analyses were conducted to determine the associations between IL17A rs8193036 (−737C/T), rs2275913 (−197G/A), rs3819024 (A/G), rs3748067 (C/T), and rs4711998 (A/G) and IL17F rs763780 (7488A/G), rs2397084 (T/C), rs1889570 (C/T), rs11465553 (G/A), and rs1266828 (T/C) polymorphisms and asthma susceptibility. A total of 20 studies were included in this meta‐analysis. Our results revealed the IL17A rs8193036 CC genotype was associated with asthma susceptibility (odds ratio [OR] = 1.490, 95% confidence interval [CI] = 1.027–2.161, p = .036). However, stratification by ethnicity indicated no association between this polymorphism and asthma in European and Asian subjects. Furthermore, no association was found between this polymorphism and asthma using the allele contrast, dominant or homozygous contrast models. No evidence of an association was found between any of the other IL17A and IL17F polymorphisms and asthma susceptibility in this meta‐analysis. This meta‐analysis showed that, among the studied polymorphisms, only the CC genotype of IL17A rs8193036 is associated with asthma susceptibility.
The unique roles of threat perception and misinformation accuracy judgments in the relationship between political orientation and COVID‐19 health behaviors
Authors: Olivett Vincenzo J. , Maranges Heather M. , March David S. 
Published: January 2023

AbstractNot everyone engages in COVID‐19 related preventative health behaviors (PHB; e.g., mask wearing, social distancing) despite their demonstrated effectiveness for mitigating the spread of COVID‐19. In the United States, for instance, PHBs emerged as (and remain) a partisan issue. The current work examines partisan gaps in PHB by considering both informational and perceptual factors related to COVID‐19. Specifically, we focus on politically motivated belief in COVID‐19 (mis)information and simultaneously consider the roles of physical threat and disgust perception. We find that poor performance in misinformation accuracy judgments and subsequently lower COVID‐19 threat perceptions sequentially predict less PHB engagement. In Study 1 (N = 87 US undergraduate students), higher conservatism predicted lower COVID‐19 threat perceptions but not COVID‐19 disgust perceptions. Study 2 (N = 168 US undergraduate students) replicated this effect, while demonstrating that the relationship between stronger conservatism and lower engagement in PHB was mediated by higher accuracy judgments of COVID‐19 misinformation and, in turn, lower perceptions of COVID‐19 threat but not disgust. This suggests that considering threat perception is essential to understanding how politically motivated endorsement of COVID‐19 misinformation shapes PHB.