bluuebunny/crossref_metadata_2025_split huggingface dataset:
Emerging concepts in oligodendrocyte and myelin formation, inputs from the zebrafish model
Authors: Masson Mary‐Amélie , Nait‐Oumesmar Brahim 
Published: January 2023

AbstractOligodendrocytes (OLs) are the myelinating cells of the central nervous system (CNS), which are derived from OL precursor cells. Myelin insulates axons allowing the saltatory conduction of action potentials and also provides trophic and metabolic supports to axons. Interestingly, oligodendroglial cells have the capacity to sense neuronal activity, which regulates myelin sheath formation via the vesicular release of neurotransmitters. Neuronal activity‐dependent regulation of myelination is mediated by specialized interaction between axons and oligodendroglia, involving both synaptic and extra‐synaptic modes of communications. The zebrafish has provided key advantages for the study of the myelination process in the CNS. External development and transparent larval stages of this vertebrate specie combined with the existence of several transgenic reporter lines provided key advances in oligodendroglial cell biology, axo‐glial interactions and CNS myelination. In this publication, we reviewed and discussed the most recent knowledge on OL development and myelin formation, with a focus on mechanisms regulating these fundamental biological processes in the zebrafish. Especially, we highlighted the critical function of axons and oligodendroglia modes of communications and calcium signaling in myelin sheath formation and growth. Finally, we reviewed the relevance of these knowledge's in demyelinating diseases and drug discovery of pharmacological compounds favoring myelin regeneration.
Breast and cervical cancer screening rates in student‐run free clinics: A systematic review
Authors: Xiao Sophia Y. , Major Catherine Kendall , O'Connell Katie A. , Lee David , Lin Christine , Sarino Esther , Chen Kevin 
Published: January 2023

AbstractObjectiveTo assess rates of breast and cervical cancer screening at student‐run free clinics to understand challenges and strategies for advancing quality and accessibility of women's health screening.MethodsThe authors performed a systematic search of publications in Ovid MEDLINE, PubMed, Web of Science, and Google Scholar databases from database inception to 2020. English‐language publications assessing rates of breast and cervical cancer screening in student‐run free clinics were included.Structured data extraction was completed for each publication by two reviewers independently. Risk of bias was assessed using a modified Agency for Healthcare Research and Quality checklist. Results were synthesized qualitatively because of study heterogeneity.ResultsOf 3634 references identified, 12 references met study inclusion criteria. The proportion of patients up‐to‐date on breast cancer screening per guidelines ranged from 45% to 94%. The proportion of patients up‐to‐date on cervical cancer screening per guidelines ranged from 40% to 88%.ConclusionStudent‐run free clinics can match breast and cervical cancer screening rates among uninsured populations nationally, although more work is required to bridge the gap in care that exists for the underinsured and uninsured.
Testing identifying assumptions in bivariate probit models
Authors: Acerenza Santiago , Bartalotti Otávio , Kédagni Désiré 
Published: January 2023

SummaryThis paper considers the bivariate probit model's identifying assumptions: linear index specification, joint normality of errors, instrument exogeneity, and relevance. First, we develop sharp testable equalities that detect all possible observable violations of the assumptions. Second, we propose an easy‐to‐implement testing procedure for the model's validity using existing inference methods for intersection bounds. The test achieves correct empirical size and performs well in detecting violations of the conditions in simulations. Finally, we provide a road map on what to do when the bivariate probit model is rejected, including novel bounds for the average treatment effect that relax the normality assumption.
A new graph parameter to measure linearity
Authors: Charbit Pierre , Habib Michel , Mouatadid Lalla , Naserasr Reza 
Published: January 2023

AbstractConsider a sequence of Lexicographic Breadth‐First‐Search vertex orderings where each ordering is used to break ties for . Since the total number of vertex orderings of a finite graph is finite, this sequence must end in a cycle of vertex orderings. The possible length of this cycle is the main subject of this work. Intuitively, we prove for graphs with a known notion of linearity (e.g., interval graphs with their interval representation on the real line), this cycle cannot be too big, no matter which vertex ordering we start with. More precisely, it was conjectured by Dusart and Habib that for cocomparability graphs, the size of this cycle is always 2, independent of the starting order. Furthermore Stacho asked whether for arbitrary graphs, the size of such a cycle is always bounded by the asteroidal number of the graph. In this work, while we answer this latter question negatively, we provide support for the conjecture on cocomparability graphs by proving it for the subclass of domino‐free cocomparability graphs. This subclass contains cographs, proper interval, interval and cobipartite graphs. We also provide simpler independent proofs for each of these cases which lead to stronger results on this subclasses.
Preventive effect of tilapia skin collagen hydrolysates on ulcerative colitis mice based on metabonomic and16 S rRNAgene sequencing
Authors: Chen Zhaoni , Nong Yunyuan , Wang Qianyi , Feng Linlin , He Ying , Guo Bingjian , Qin Yuelian , Zhong Xinyu , Qin Jinghua , Wei Jinbin , Dong Min , Pan Shihan , Su Zhiheng 
Published: January 2023

AbstractBACKGROUNDTilapia skin collagen hydrolysates (TSCHs) are the product of enzymatic hydrolysis of collagen, which is mainly extracted from tilapia skin. The components of TSCHs have recently been reported to play a preventive role in dextran sulfate sodium (DSS)‐induced ulcerative colitis (UC). However, it has not been illustrated whether TSCHs can prevent against DSS‐induced UC via the gut microbiota and its derived metabolites.RESULTSTSCHs are mainly composed of amino acids, which have similar characteristics to collagen, with most having a molecular weight below 5 kDa. In a mouse model of UC, TSCHs had no toxic effect at a dose of 60 g kg−1and could reduce body weight changes, colon length, histopathological changes and score, and the level of the serum inflammatory cytokine interleukin (IL)‐6. Concurrently, 16 S rRNA sequencing showed that TSCHs significantly reduced the abundance of Bacteroidetes and Proteobacteria at the phylum level andnorank_f__MuribaculaceaeandEscherichia‐Shigellaat the genus level, while they increased the abundance of Firmicutes at the phylum level andLachnoclostridium,Allobaculum,Enterorhabdus, andunclassified__f__Ruminococcaceaeat the genus level. Target metabolomic analysis showed that TSCHs elevated the concentration of total acid, acetic acid, propanoic acid, and butanoic acid, but reduced isovaleric acid concentrations. Moreover, Pearson correlation analysis revealed thatAllobaculum,unclassified_Ruminococcaceae, andEnterorhabduswere positively correlated with acetic acid and butyric acid, but notEscherichia‐Shigella.CONCLUSIONThese findings suggest that TSCHs can prevent UC by modulating gut microbial and microbiota‐derived metabolites. © 2023 Society of Chemical Industry.
In vitro Nasodine Can be an Effective Antibiofilm Agent for Biofilms that May Cause CRS
Authors: Hale Samuel J M , Lux Christian A , Kim Raymond , Biswas Kristi , Tucker Simon , Friedland Peter , Mackenzie Brett Wagner , Douglas Richard G 
Published: January 2023

ObjectivesBacterial biofilms on the sinonasal mucosa, especially biofilms of Staphylococcus aureus, are associated with greater severity and recalcitrance of chronic rhinosinusitis (CRS). There are few, if any, antibiofilm agents suitable for sinonasal application available for the management of this problem. Nasodine® Nasal Spray (Nasodine) is a 0.5% povidone‐iodine‐based formulation that has been developed for sinonasal application. We investigated the antibiofilm efficacy of Nasodine to determine whether it may be a candidate for the treatment of biofilm‐associated CRS.MethodsBiofilms of S. aureus ATCC 6538 were grown in vitro using the Centers for Disease Control biofilm reactor. Intact biofilms were treated by immersion in 0.9% saline (control), half concentration Nasodine, or full concentration Nasodine for between 5 min and 6 h. Further biofilm cells were dispersed into suspension then treated for between 30 s and 5 min. Surviving bacteria were then enumerated by culture and counting colonies, and the log10 reduction in viable bacteria was compared with control.ResultsNasodine demonstrated time and concentration‐dependent bacterial killing against intact biofilm. Statistically significant reductions in viable bacteria from intact biofilms were seen with exposures as brief as 5 min. Nasodine consistently eradicated dispersed biofilm within 1 min.ConclusionNasodine is highly active against biofilms of S. aureus ATCC 6538 in vitro. Biofilm killing is impeded by the presence of the intact biofilm structure.Lay summary:In chronic rhinosinusitis (CRS), bacterial communities called biofilms are associated with more severe inflammation. An iodine‐based nasal spray called Nasodine almost completely eradicates bacterial biofilms after 6 h of exposure. Nasodine may be useful for treating CRS. Laryngoscope, 133:2490–2495, 2023
Functional and Symmetry Outcomes After Forehead Flap Reconstruction of Medial Peri‐Ocular Defects
Authors: Agarwal Aarti , Philips Ramez , Landers Kathryn , Savitch Samantha , Barbarite Eric , Krein Howard , Heffelfinger Ryan 
Published: January 2023

BackgroundOrbital defects have a profound impact on orbital function and symmetry of the face and are difficult to reconstruct given the complexity of this area. The paramedian forehead flap (PMFF) has not been well studied in reconstruction of orbital defects.MethodsRetrospective review of patients who underwent reconstruction of periorbital defects with PMFF between 2016 and 2021. Variables were ocular adnexal asymmetry, functional outcomes, and orbital complications.ResultsEighteen patients met inclusion criteria. Mean defect size was 11.1 ± 7.5 cm. The most common subsite involved was medial canthus in 88.9% of patients. There was no statistically significant difference between mean medial canthus to midline ratio and mean medial brow to midline ratio when compared to the assumed normal of 1. The medial canthus to pupil ratio and medial canthus to lateral canthus ratio had a statistically significant mean difference from 1.0 (p = 0.003 for both). In 22.2% of patients, the orbit was functional with impairment; the remaining had no impairment. Surgical sequelae occurred in 12/18 (66.7%) of patients, most commonly epiphora in 9/18 (50%) of patients, and ectropion in 5/18 (27.7%).ConclusionThe PMFF is feasible for medial periorbital reconstruction with acceptable functional and symmetrical outcomes and low morbidity.Level of Evidence4 Laryngoscope, 133:2584–2589, 2023
Featured Front Cover
Authors: Pricope Narcisa G. , Daldegan Gabriel A. , Zvoleff Alex , Mwenda Kevin M. , Noon Monica , Lopez‐Carr David 
Published: January 2023

The cover image is based on the Research Article Operationalizing an integrative socio‐ecological framework in support of global monitoring of land degradation by Narcisa G. Pricope et al., https://doi.org/10.1002/ldr.4447.image
What Is Hemidystonia?
Authors: Vizcarra Joaquin A. , Jinnah Hyder A. 
Published: January 2023

ABSTRACTBackgroundHemidystonia is defined as dystonia restricted to one side of the body. It is traditionally believed to result from a lesion in the contralateral hemisphere.ObjectivesTo describe a series of hemidystonia patients without lesions on brain imaging.MethodsWe searched for individuals with potential hemidystonia who were included in the Dystonia Coalition or Movement Disorder Society Genetic mutation database (MDSgene), and conducted a systematic review.ResultsWe found 10 individuals classified as hemidystonia or with homolateral limb dystonia among 3696 cases enrolled by the Dystonia Coalition, 9 cases in MDSgene, and one idiopathic case in the literature. None had evidence of a brain lesion. Body distributions used to define hemidystonia varied considerably and were not always restricted to one side of the body.ConclusionsHemidystonia may be idiopathic or genetic, without any obvious brain lesion. The varied use of the term suggests the need for more specific clinical criteria to define “half the body.”
A high‐gain quasi‐Yagi antenna using nested metaresonator structures
Authors: Turan Goksel , Odabasi Hayrettin 
Published: January 2023

AbstractThis article proposes a high‐gain quasi‐Yagi antenna using nested metaresonator structures with a systematic design approach. The nested metaresonators are used as a director element instead of conventional strip directors. The gain enhancement of the proposed antenna is based on strong electromagnetic coupling between the driver and metaresonator director elements. The proposed antenna has a gain of 7.6–9 dBi with a bandwidth of 8.6% between 2.43 and 2.65 GHz ( dB). It achieves a maximum gain increase of 4 dBi compared to the conventional quasi‐Yagi antenna and 2 dBi compared to the four‐director quasi‐Yagi antenna. The proposed antenna can be used for wireless communication applications that require high gain.
Extracellular vesicles: Focus on peri‐implantation period of pregnancy in pigs
Authors: Guzewska Maria M. , Szuszkiewicz Joanna , Kaczmarek Monika M. 
Published: January 2023

AbstractThe establishment of cell‐to‐cell communication between the endometrium and the developing embryo is the most important step in successful mammalian pregnancy. Close interaction between the uterine luminal epithelium and trophoblast cells requires triggering timely molecular dialog for successful maternal recognition of pregnancy, embryo implantation, and placenta development. Quite recently, extracellular vesicles (EVs) carrying unique molecular cargo emerged as evolutionarily conserved mediators of cell‐to‐cell communication during early pregnancy. To date, the presence of EVs at the embryo–maternal interface has been demonstrated in numerous mammals, including domestic livestock, such as pigs. However, few studies have focused on revealing the mechanism of EV‐mediated crosstalk between developing early embryos and receptive endometrium. Over the past years, it has appeared that understanding the role of EVs in mammalian reproduction can substantially improve our understanding of the biological challenges of successful reproductive performance. This review describes current knowledge of EVs, specifically in relation to the peri‐implantation period in pigs, characterized by common features of embryo implantation and high embryonic mortality in mammals.
Nonconvex optimization for third‐order tensor completion under wavelet transform
Authors: Yu Quan , Bai Minru 
Published: January 2023

AbstractThe main aim of this paper is to develop a nonconvex optimization model for third‐order tensor completion under wavelet transform. On the one hand, through wavelet transform of frontal slices, we divide a large tensor data into a main part tensor and three detail part tensors, and the elements of these four tensors are about a quarter of the original tensors. Solving these four small tensors can not only improve the operation efficiency, but also better restore the original tensor data. On the other hand, by using concave correction term, we are able to correct for low rank of tubal nuclear norm (TNN) data fidelity term and sparsity of ‐norm data fidelity term. We prove that the proposed algorithm can converge to some critical point. Experimental results on image, magnetic resonance imaging and video inpainting tasks clearly demonstrate the superior performance and efficiency of our developed method over state‐of‐the‐arts including the TNN and other methods.
Addressing adherence to guidelines on prevention of acute chemotherapy‐induced nausea and vomiting in pediatric patients
Authors: Kacar Marija , MacDonald Paula , Gibson Paul 
Published: January 2023

AbstractBackgroundChemotherapy‐induced nausea and vomiting (CINV) is a distressing adverse effect in children receiving cancer treatment. There are evidence‐based pediatric clinical practice guidelines (CPG) on chemotherapy emetogenicity and acute CINV prevention, but adherence to these guidelines is low.ProcedureA quality improvement‐based study was conducted at McMaster Children's Hospital. The SMART aim was to increase adherence to guidelines on prevention of acute CINV in hospitalized patients receiving high (HEC) and moderately emetogenic chemotherapy (MEC) from baseline 25% to more than 70% by June 2021. Barriers were identified by process mapping, and a series of interventions were implemented.ResultsGuideline adherence was assessed in 270 inpatient chemotherapy administrations (HEC, MEC). Data were collected on 131 charts pre interventions and 139 charts post interventions. Interventions included education, addition of guideline‐recommended anti‐emetics to the inpatient formulary, and implementation of a standardized CPG tool. Initial rates of total CINV guideline adherence were 25%, which improved to 72% post intervention (p < .001). In subgroup analysis, guideline adherence in the MEC group improved from 13% to 34% (p = .015), and in the HEC group from 32% to 93% (p < .001). The most common reason for nonadherence in the HEC group was failure to use aprepitant as anti‐emetic, and in MEC was option for ondansetron monotherapy prophylaxis.ConclusionUsing quality improvement methodology, barriers to guideline adherence were identified and interventions implemented. Guideline adherence for prevention of CINV improved, particularly in the HEC group but less for the MEC group. Future steps will include sustainability of interventions and addressing adherence in the MEC group.
The effect of resveratrol supplementation on biomarkers of liver health: A systematic review and meta‐analysis of randomized controlled trials
Authors: Soltani Sepideh , Sharifi‐Zahabi Elham , Sangsefidi Zohreh Sadat , Ahmadi Vasmehjani Azam , Meshkini Fatemeh , Clayton Zachary Stephen , Abdollahi Shima 
Published: January 2023

AbstractThis study aimed to evaluate the effect of resveratrol on liver biomarkers in adult participants, using systematic review and meta‐analysis of randomized controlled trials. PubMed, Scopus, Web of Science and Cochran Library was searched, up to October 2021. The pooled effects were calculated using a random‐effects model and expressed as weighted mean difference and 95% confidence interval. The methodological quality of studies as well as certainty of evidence were assessed by standard tools. Thirty‐seven relevant trials were found. Although overall analysis found no significant change, subgroup analysis showed a significant improvement in alanine aminotransferase (ALT; −7.79 U/L) and glutamyl transferase (−6.0 U/L) in patients with liver disorders, and ALT (−2.22 U/L) in younger adults; however, high‐dose supplementation (>1,000 mg/day) appeared to increase alkaline phosphatase concentration (+5.07 U/L). ALT also increased in older adults (+2.33 U/L) following resveratrol supplementation. We found resveratrol did not have a significant effect on liver health in the general population. However, resveratrol could be effective in patients with liver disorders. Our findings also suggest that high‐dose resveratrol administration and supplementation in older adults should be performed with caution. Further high‐quality clinical trials are also needed to firmly establish the clinical efficacy of resveratrol.
Finite– and fixed–time observers for uncertain multiple–outputs linear systems with unknown inputs
Authors: Ríos Héctor , Dávila Jorge , Fridman Leonid 
Published: January 2023

SummaryIn this paper a family of homogeneity–based observers is proposed to estimate the state of a class of multiple–outputs linear systems with some parametric uncertainties and unknown inputs. Such a family of observers possesses robustness, finite– and fixed–time convergence properties depending on the considered parametric uncertainties and unknown inputs. The structure of these observers is simple since requires neither additional observers, for an a priori stabilization, nor complex transformations, and allows us to straightforwardly apply the observers for the case of multiple–outputs. The proposed structure is based on relative degree sufficient conditions that imply the strong observability of the system. Some simulation results illustrate the performance of the proposed homogeneous observers.
Density‐Dependence of Surface Transport in Tellurium‐Enriched Nanograined Bulk Bi2Te3
Authors: Izadi Sepideh , Bhattacharya Ahana , Salloum Sarah , Han Jeong Woo , Schnatmann Lauritz , Wolff Ulrike , Perez Nicolas , Bendt Georg , Ennen Inga , Hütten Andreas , Nielsch Kornelius , Schulz Stephan , Mittendorff Martin , Schierning Gabi 
Published: January 2023

AbstractThree‐dimensional topological insulators (3D TI) exhibit conventional parabolic bulk bands and protected Dirac surface states. A thorough investigation of the different transport channels provided by the bulk and surface carriers using macroscopic samples may provide a path toward accessing superior surface transport properties. Bi2Te3 materials make promising 3D TI models; however, due to their complicated defect chemistry, these materials have a high number of charge carriers in the bulk that dominate the transport, even as nanograined structures. To partially control the bulk charge carrier density, herein the synthesis of Te‐enriched Bi2Te3 nanoparticles is reported. The resulting nanoparticles are compacted into nanograined pellets of varying porosity to tailor the surface‐to‐volume ratio, thereby emphasizing the surface transport channels. The nanograined pellets are characterized by a combination of resistivity, Hall‐ and magneto‐conductance measurements together with (THz) time‐domain reflectivity measurements. Using the Hikami‐Larkin‐Nagaoka (HLN) model, a characteristic coherence length of ≈200 nm is reported that is considerably larger than the diameter of the nanograins. The different contributions from the bulk and surface carriers are disentangled by THz spectroscopy, thus emphasizing the dominant role of the surface carriers. The results strongly suggest that the surface transport carriers have overcome the hindrance imposed by nanoparticle boundaries.
Label‐Free Identification of Exosomes using Raman Spectroscopy and Machine Learning
Authors: Parlatan Ugur , Ozen Mehmet Ozgun , Kecoglu Ibrahim , Koyuncu Batuhan , Torun Hulya , Khalafkhany Davod , Loc Irem , Ogut Mehmet Giray , Inci Fatih , Akin Demir , Solaroglu Ihsan , Ozoren Nesrin , Unlu Mehmet Burcin , Demirci Utkan 
Published: January 2023

AbstractExosomes, nano‐sized extracellular vesicles (EVs) secreted from cells, carry various cargo molecules reflecting their cells of origin. As EV content, structure, and size are highly heterogeneous, their classification via cargo molecules by determining their origin is challenging. Here, a method is presented combining surface‐enhanced Raman spectroscopy (SERS) with machine learning algorithms to employ the classification of EVs derived from five different cell lines to reveal their cellular origins. Using an artificial neural network algorithm, it is shown that the label‐free Raman spectroscopy method's prediction ratio correlates with the ratio of HT‐1080 exosomes in the mixture. This machine learning‐assisted SERS method enables a new direction through label‐free investigation of EV preparations by differentiating cancer cell‐derived exosomes from those of healthy. This approach will potentially open up new avenues of research for early detection and monitoring of various diseases, including cancer.