bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mediating role of self-compassion in the relationship between psychological flexibility and psychological well-being in women with breast cancer
Authors: Chen Haoting , Abdelrasheed Nasser Said Gomaa , Mecheser Abdullah Eiada , Tayyib Nahla A , Ramaiah Pushpamala , Prasad KDV , Estrada-Araoz Edwin Gustavo , Alkhayyat Safa , Ramadan Montather F. , Abdollahi Abbas 
Published: May 2023

Abstract
Background: Previous studies have investigated the relationship between psychological flexibility and psychological well-being among university students. In addition to examining the relationship between these two variables, this study enhances our understanding about the process underlying the relationship between psychological flexibility and psychological well-being among women with breast cancer. The aim of the present study was to test the mediating role of self-compassion in the relationship between psychological flexibility and psychological well-being among Iranian women with breast cancer.
Methods: The participants of this study, 220 women with breast cancer (ages 28 to 58 years, mean age: 42.16, SD: ±6.9.54) from three hospitals, in Tehran, Iran completed questionnaires about psychological flexibility, self-compassion and psychological well-being.
Results: The results from structural equation modeling indicated that psychological flexibility and self-compassion positively predicted psychological well-being and psychological inflexibility negatively predicted psychological well-being among breast cancer patients. The findings from mediation analysis demonstrated that self-compassion partially mediated the relationships between psychological flexibility and psychological inflexibility with psychological well-being. The present study brings to light an underlying mechanism of the relationships between psychological flexibility and psychological inflexibility with psychological well-being via the mediating variable of self-compassion for patients with breast cancer.
Reduced expression of the Htr2a, Grin1, and Bdnf genes and cognitive inflexibility in a model of high compulsive rats
Authors: Prados-Pardo Angeles , Martin-Gonzalez Elena , Mora Santiago , Martin Carlos , Olmedo-Cordoba Manuela , Perez-Fernandez Cristian , Sanchez-Santed Fernando , Moreno-Montoya Margarita 
Published: May 2023

Abstract
Compulsivity is a core symptom in different psychopathological disorders, characterized by excessive behaviors and behavioral inflexibility. In preclinical studies, the selection of high drinker (HD) versus low drinker (LD) rats by schedule-induced polydipsia (SIP) is a valid model of compulsivity. HD rats shows a compulsive phenotype with a reduction in serotonin 2A (5-HT2A) receptor binding levels in the frontal cortex (FC). However, is necessary further explore the cognitive components regarding inflexibility in the compulsive HD rats, as well as, the related brain gene expression. Here, first, we assessed spatial memory and cognitive inflexibility by Morris Water Maze (MWM), working and reference memory by Radial Arm Maze, and behavioral deficits in stimulus processing by novel object recognition test. Second, we analyed the genetic expression of 5HT2A, 5HT2C, glutamate NMDA receptors, and brain-derived neurotrophic factor (BDNF) in FC, hippocampus, and amygdala. HD rats confirmed a cognitive inflexibility profile in the reversal condition in MWM compared to LD rats, while no differences were observed in stimulus processing, spatial and working memory. Moreover, HD rats showed a reduced expression of the Htr2a,Grin1, and Bdnf genes in FC. Furthermore, there was a negative correlation between the relative expression of the Htr2a, Grin1 and Bdnf genes in FC and the level of compulsive water intake in HD rats on SIP. These data reveal that cognitive inflexibility may not be associated with memory or stimulus processing alterations, but may result from a region-specific alteration on FC of the gene expression Htr2a, Grin1, and Bdnf in compulsive individuals.
Evaluating the Effectiveness of Different Software Testing Frameworks on Software Quality
Authors: de Silva Dilshan , Samarasekara H.M.P.P.K.H , Ariyarathna W.K.K.H , de Silva L.S.M , de Silva W.L.P , Methmini P.K Hasara , Wijewickrama G.R.P.S , Madushika H.A.J 
Published: May 2023

Abstract
The effectiveness of software testing frameworks on software quality is an important area in software engineering. This paper evaluates the effectiveness of popular software testing frameworks, namely Selenium, TestNG, Cucumber, JMeter, and Cypress, on different software qualities, including maintainability, security, code quality, reliability, performance, and usability. The study includes a literature review of previous studies on the effectiveness of these testing frameworks and an empirical study that compares the performance of these frameworks on the selected software qualities using a set of benchmark applications. The results show that the effectiveness of a software testing framework on a particular software quality depends on the specific requirements of the project. For example, Selenium and Cypress are effective for testing user interface functionality and usability, while JMeter is effective for load and stress testing. Thus, software developers and testers should carefully evaluate the different testing frameworks in relation to the software quality requirements of their project before selecting a testing framework. The study concludes that software testing frameworks play a crucial role in ensuring software quality, and selecting the appropriate testing framework is important for achieving the desired software quality goals.
Disease Burden in Refugees in Mainland Grecian Refugee Camps, 2016-2017: A retrospective cross-sectional study
Authors: Scales Sarah Elizabeth , Park Jee Won , Nixon Rebecca , Guha-Sapir Debarati , Horney Jennifer A 
Published: May 2023

Abstract
Background.
Despite the importance of baseline health data for evidence-informed decision-making, these data are rarely available for displaced populations. At the height of the European refugee crisis, most of those seeking asylum in Europe were from regions with high prevalences of communicable and non-communicable diseases. To create an epidemiologic profile for refugees in mainland Grecian refugee camps, this study assessed the prevalence of 11 communicable and non-communicable diseases among refugees utilizing Médecins du Monde (MdM) in-camp clinics.
Methods.
The prevalences of selected diseases among individuals utilizing MdM services were determined from data collected at mainland Grecian refugee camps clinics from April 2016 - July 2017. Overall and age-specific prevalences were reported. Differences in disease burden among refugees from the largest sending countries - Afghanistan and Syria - were compared using prevalence ratios and 95% confidence intervals. Patterns in results were compared with disease burden estimates in sending countries and with findings from comparable settings.
Results.
Respiratory tract infections (RTIs) were the most prevalent outcome. Among RTIs, upper RTIs were most common, with a prevalence of nearly 40%; throughout the study period, over 46% of children under 18 years had at least one upper RTI consultation. Musculoskeletal conditions (3.64%), were the most prevalent non-communicable outcome, followed by hypertension (2.21%) and asthma (1.28%). Afghans were 31.68% more likely than Syrians to have a consultation for at least one condition (PR: 1.32; 95% CI: 1.25, 1.39). The prevalence of RTIs was comparable to sending countries, but there was a comparatively lower burden of other conditions among refugees than literature estimates from sending countries.
Conclusion.
Refugees utilizing MdM clinics in camps had higher burdens of communicable diseases - predominantly RTIs - relative to non-communicable diseases. Non-communicable disease burdens were comparatively lower than reported prevalences from in-country populations. These findings can be attributed to a range of considerations including differences in demographic profiles between sending countries and refugee populations and missed opportunities for utilizing clinical care. Based on these data, displaced populations have considerable health needs. Further investment is needed to capture the health profiles of displaced populations to support evidence-informed decision-making processes in humanitarian emergency responses.
Similarity matching of TCM prescription rational medication based on Siamese network
Authors: Xiong Wangping , Wang Kaiqi , Liu Shixiong , Liu Zhaoyang , Zhu Yimin , Liu Peng , Yang Ming , Zhou Xian 
Published: May 2023

Abstract
Background
Chinese medicine taking is an important link to ensure rational medicine use, and prescription matching can excavate more information on medicine use. traditional Chinese medicine (TCM) prescription data feature relationship is complex and multi-dimensional, and the prescription similarity matching model suffers from single attribute quantification, lack of elemental relationships, and the similarity of efficacy and primary function cannot be quantified, which brings challenges to the quantification of prescription similarity.
Methods
The focus of this study is to construct a framework for matching traditional Chinese medicine prescriptions with classic formulae, which integrates multiple features (MFTCMC) and explores the classic formulae contained in prescriptions to provide references for the medication-taking behavior of clinical traditional Chinese medicine prescriptions. Firstly, the prescription compatibility weight is calculated through Analytic Hierarchy Process (AHP), and the various dosage weights of herbs are integrated to construct a comprehensive weighting method, which selects a set of key herbs to form a core prescription. Secondly, the performance features of the core prescription are quantified by using the attribute labeling strategy of Chinese medicine properties. Finally, the relationship features of the core prescription are extracted by using a Bidirectional Long Short-Term Memory Network (BiLSTM), and the vector representation similarity matrix is constructed by combining the Siamese network framework. The matching score between the core prescription and the classic formula is calculated through a fully connected layer, and the traditional medication method of the matched classic formula is selected to provide references for the medication behavior of clinical prescriptions.
Results
Based on the prescription matching dataset constructed in this paper, the precision and F1 value reached 94.45% and 94.34% respectively, which is a significant improvement compared to several other models.
Conclusions
Compared with other models, the proposed MFTCMCF can effectively improve the performance of matching between prescriptions and classic formulae, and the results are more in line with the clinical practice of traditional Chinese medicine. This further improves the medication behavior of clinical prescriptions and provides new insights for research on recommended methods of taking traditional Chinese medicine prescriptions.
Psychometric Properties of the Wellbeing Literacy 6-item (Well-Lit 6) scale in Chinese Military Academy Cadets
Authors: Jia Zhen , Zheng Fangfang , Wang Feifei , Yang Guoyu 
Published: May 2023

Abstract
Background
This study aimed to examine the psychometric properties of the wellbeing literacy 6-item (Well-Lit 6) scale in Chinese military academy cadets.
Methods
A total of 3218 undergraduate students from five military academies in China were recruited to complete questionnaires online. The data set was analyzed through item analysis to examine the homogeneous reliability and split-half reliability of the Chinese version of Well-Lit 6 scale. Structural validity was tested through exploratory factor analysis and confirmatory factor analysis. Correlation analysis was then conducted to verify the correlational validity and convergent-discriminant validity of the calibration scale, and regression analysis to examine the incremental validity. Independent sample t-test and one-way ANOVA were also conducted to explore the characteristics of wellbeing literacy among Chinese military academy cadets.
Results
(1) The items of the scale showed high discrimination; (2) The alpha coefficient of the scale was 0.986 and the split-half reliability was 0.981, indicating high homogeneous reliability and split-half reliability; (3) The scale model fitted well and displayed structural validity; (4) The correlation between well-being literacy and related indicators was significant (P < 0.001), and the calibration correlation and convergent-discriminant validity of the scale were high; (5) After gradually adding demographic variables, known predictors factors and well-being literacy, the ∆R2 for subjective well-being, life satisfaction, depression, and anxiety ranged from 0.036 to 0.067, 0.184 to 0.340, and 0.009 to 0.017, respectively (all P < 0.001), showing high incremental validity; (6) the total well-being literacy scores differed significantly by gender (P < 0.05), grade (P < 0.001), and parenting style (P < 0.001) .
Conclusion
The Chinese version of the Well-Lit 6 is reliable and valid in predicting and accessing the subjective well-being, life satisfaction, emotion regulation and psychological resilience of Chinese military academy cadets.
Association between immune-related adverse events and survival in patients with renal cell carcinoma treated with nivolumab plus ipilimumab: Immortal time bias-corrected analysis.
Authors: Washino Satoshi , Shirotake Suguru , Takeshita Hideki , Inoue Masaharu , Miura Yuji , Hyodo Yoji , Kagawa Makoto , Izumi Keita , Oyama Masafumi , Kawakami Satoru , Saito Kazutaka , Matsuoka Yoh , Taniuchi Satsuki , Shintani Ayumi , Miyagawa Tomoaki 
Published: May 2023

Abstract
Background: Immune-related adverse events (irAEs) in patients treated with immune check inhibitors are associated with favourable response rate and survivals in multiple cancers, including renal cell carcinoma (RCC). The aim of this study was to investigate how irAEs were associated with improved survivals in advanced RCC patients treated with nivolumab plus ipilimumab.
Materials and methods: This retrospective study included patients who received nivolumab plus ipilimumab between September 2018 and February 2022 at six centres. We assessed associations of the development and the number of irAEs with overall survival (OS) and progression-free survival (PFS). To eliminate immortal time bias, landmark analysis and a Cox model with time-dependent variables were used.
Results: This study included 129 patients with a median follow-up of 12.3 months. The 2-year OS and PFS rates were 55% and 42%, respectively. Ninety six patients experienced irAEs. The development of irAEs was positively associated with OS and PFS rates (hazard ratio [HR] 0.328, 95% confidence interval [CI] 0.165–0.648, p = 0.001; HR 0.334, 95% CI 0.151–0.737, p = 0.007). Patients who experienced multiple irAEs had longer OS (HR 0.507, 95% CI 0.235–1.097, p = 0.085 or HR 0.245, 95% CI 0.110–0.544, p < 0.001) and PFS (HR 0.572, 95% CI 0.316–1.036, p = 0.085 or HR 0.267, 95% CI 0.113–0.628, p = 0.002) compared with those who experienced single or zero irAE.
Conclusions: Developing irAEs, particularly multiple irAEs, is associated with favourable survivals in advanced RCC patients treated with nivolumab plus ipilimumab.
Desynchronization of neuronal firing in multiparameter transcranial ultrasound stimulation
Authors: Bian Nannan , Long Ai , Yuan Yi 
Published: May 2023

Abstract
Low-intensity transcranial ultrasound stimulation, a novel neuromodulation technique, that possesses the advantages of non-invasiveness, high penetration depth, and high spatial resolution, has achieved positive neuromodulation effects in animal studies. But the regulatory mechanism remains controversial. The intramembrane cavitation effect is considered one of the mechanisms for ultrasound neuromodulation. In this study, the modified equations of ultrasonic cavitation bubble dynamics were coupled with the dual-coupled neuron Hindmarsh-Rose model, small-world neural network model, and the Jansen-Rit neural mass model, which simulate simple coupled neurons, complex neuronal networks, and discharge signals in epileptic disorders respectively. The results demonstrated that transcranial ultrasound stimulation has an appreciable modulatory effect on neuronal firing desynchronization in Hindmarsh-Rose model and small-world neural network model. The desynchronization effect is related to the stimulation frequency and intensity. Furthermore, ultrasound stimulation has an inhibitory effect on epileptic seizures, and the effect is enhanced by increasing ultrasound frequency from 0.1-1.0MHz. This is the first combination of ultrasonic intramembrane cavitation effect theory with neurons and neural network firing desynchronization, which can provide guidance of parametric and theories support for the studies of neurological diseases such as epilepsy and Parkinson's disease.
Loneliness and Suicide Mitigation for Students using GPT3-Enabled Chatbots
Authors: Maples Bethanie , Cerit Merve , Vishwanath Aditya , Pea Roy 
Published: May 2023

Abstract
Mental health is a crisis for learners globally, and digital support is increasingly seen as a critical resource. Concurrently, Intelligent Social Agents receive exponentially more engagement than other conversational systems, but their use in digital therapy provision is nascent. A survey of over 1000 student users of the Intelligent Social Agent, Replika, investigated participants’ loneliness, perceived social support, use patterns, and beliefs about Replika. We found participants were more lonely than typical student populations but still perceived high social support. Many used Replika in multiple, overlapping ways - as a friend, a therapist, and an intellectual mirror. Many also held overlapping and often conflicting beliefs about Replika - calling it a machine, an intelligence, and a human. Critically, 3% reported Replika halted their suicidal ideation. Comparative analysis of this group with the wider participant population is provided.
Study on chemical composition analysis and lipid metabolism regulation activity of different parts of Eucommia ulmoides
Authors: Gong Pin , Zhai Pengtao , Chen Xuefeng , Sun Wangyang , Wang Peipei , Guo Yuxi , Wang Zhineng , Li Nan , Zhai Wenjun , Zheng Benzhong 
Published: May 2023

Abstract
Eucommia ulmoides has lipid-lowering, antihypertensive, hypoglycemic and anti-aging effects. The main medicinal part of Eucommia ulmoides bark (EBE), but its slow growth and peeling easily lead to tree death, which limits the extensive use of Eucommia ulmoides resources and causes the lack of Eucommia ulmoides resources. It is not clear whether Eucommia ulmoides leaves (ELE), flowers (EFE) and seeds (ESE) can be used as substitutes for Eucommia ulmoides bark. In this study, UPLC-Q-Orbitrap-MS was used to analyze the active ingredients in the bark, leaves, flowers and seeds of Eucommia ulmoides. HPLC method was established for the determination of 8 common active ingredients in the bark, leaves, flowers and seeds of Eucommia ulmoides. The content of active ingredients is also based on the current research on Eucommia ulmoides, and the regulation activity of lipid metabolism was compared. The results showed that 119 compounds were identified from 12 classes of Eucommia ulmoides, and the skin and leaves of Eucommia ulmoides contained a lot of the same active ingredients. The content of turbinol diglucoside in Eucommia ulmoides bark was the highest, and the content of chlorogenic acid in Eucommia ulmoides leaves was the highest. After Eucommia intervention, all indexes of cell model were improved and lipid metabolism regulation ability was improved: EBE, ELE, EFE, ESE; EBE and ELE had similar lipid lowering effect. After Eucommia's treatment, mRNA expression of AMPK increased in a volume-dependent manner, while mRNA expression of SREBP-1c, FAS and ACC decreased in a volume-dependent manner. Therefore, Eucommia's improvement in steatosis of HepG2 cells may be related to the regulation of AMPK, SREGP-1C, FAS and ACC signaling pathways. In conclusion, it can be concluded that Eucommia ulmoides leaves can replace Eucommia ulmoides skins in the regulation of lipid metabolism and improve the comprehensive utilization of Eucommia ulmoides resources.
Shear strength characteristics of basalt fiber-reinforced loess: experimental investigation and model prediction
Authors: Chen Chong-kun , Li Gang , Liu Jia , Xi Yu , Nan Jing-jing 
Published: May 2023

Abstract
Loess owns the characteristics of collapsibility, disintegration and solubility, which pose a challenge to engineering construction. To examine the shear strength of basalt fiber-reinforced (BFR) loess, consolidated undrained (CU) triaxial tests were conducted to explore the impacts of water content (w), fiber length (FL), fiber content (FC) and cell pressure (σ3) on the shear strength. The microstructure of reinforced loess was constructed using SEM measurements to reveal the reinforcing mechanism of basalt fibers. According to the results, the shear strength model was established taken into account the impacts of FL, FC, and fiber diameter (d) using the regression analysis method. The results showed that the peak strength of BFR soils enhanced as FL, FC, and σ3 increasing, whereas it decreased with increasing of w. The reinforcing mechanism of fibers was divided into a single tensile effect and spatial mesh effect, and the bridging effect transformed the force, which improved the overall ability of composites to resist deformation and damage. The experimental and calculated results agreed well, which suggested the model is suitable for predicting the shear strength of BFR loess. The research results can offer a guideline for the application of BFR loess in the subgrade and slope engineering.