bluuebunny/crossref_metadata_2025_split huggingface dataset:
SURVEY INDEKS KEPADATAN LALAT DI RUMAH PEMOTONGAN HEWAN (AYAM) DI KABUPATEN PANGKEP
Authors: Nurhikmayani Nurhikmayani , Mulyadi Mulyadi , Rasman Rasman , Zaenab Zaenab 
Published: January 2023

Rumah pemotongan ayam (RPA) merupakan salah satu industri peternakan dimana dilakukan pemtongan hewan ayam hidup dan mengolah menjadi karkas ayam yang siap dikomsumsi oleh konsumen. Aktivitas pemotongan unggas membawa dampak pencemaran lingkungan dan kesehatan masyarakat. Tujuan penelitian ini untuk mengetahui tingkat kepadatan lalat di rumah pemtongan hewan (ayam) di saluran pembuangan air limbah, kandang ayam transisi dan sampah buangan. Jenis penelitian yang digunakan adalah penelitian deskriptif dengan jumlah sampel 12. Hasil penelitian di pagi hari pada sarana saluran pembuangan air limbah ini didapatkan hasil kategori memenuhi syarat 2 RPH (Ayam) di pagi hari dan di sore hari 1 RPH (Ayam) sedangkan kategori tidak memenuhi syarat pada pagi hari terdapat 10 RPH (Ayam) dan sore hari 11 RPH (Ayam), sedangkan di sampah buangan di pagi hari yang memenuhi syarat terdapat 2 RPH (Ayam) dan di sore hari 1 RPH (Ayam) dan kategori tidak memenuhi syarat terdapat pada pagi hari 10 RPH (Ayam) dan di sore hari 11 RPH (Ayam). Dan di kandang ayam transisi pada pagi dan sore hari dengan kategori memenuhi syarat 1 RPH (Ayam) dan 11 RPH (Ayam) kategori tidak memenuhi syarat. Adapun kesimpulan penelitian bahwa kondisi sanitasi sangat berpengaruh terhadap indeks kepadatan lalat. Diharapakan pada sarana air limbah menggunakan saluran pembuangan tertutup, tempat sampah tertutup dan kandang ayam transisi yang sesuai dengan peraturan. Kata Kunci : Kepadatan lalat, Spal, Sampah buangan, Kandang ayam transisi.
Processing and Characterization of Polypropylene Nanocomposite Films Reinforced with Hexagonal Boron Nitride Nanosheets
Authors: Bayramoğlu Gülay , Mudu Mehmet 
Published: January 2023

In this study, we synthesized hexagonal boron nitride nanosheets (h-BNN) via the molten hydroxide exfoliation method which results in small flakes and nanoscrolls. The resultant h-BNNs can be dispersed in various solvents such as water, ethanol, and acetone, and form a stable dispersion. The morphological and structural analysis of h-BNNs were performed with Fourier Transform infrared spectroscopy (FTIR), X-ray diffractometry (XRD), and scanning electron microscopy (SEM). The masterbatch (MB) method was used to incorporate the h-BNNs into the polypropylene (PP) matrix via melt mixing. Dilution and film production processes were performed using a twin screw extruder. Nanocomposite films having an h-BNN weight ratio of 1%, 2%, 3%, and 5% were prepared. Thermogravimetric analyzer (TGA) and differential scanning calorimetry (DSC) were used to investigate the thermal stability. Crystallization (Tc) temperatures were increased with the increased amount of h-BNNs and h-BNNs nucleating agent behavior on the PP crystallization was observed. Oxidation induction time (OIT) of the pure PP was increased from 8.84 min to 17.82 min. The results show a considerable effect of the h-BNN content on the thermo-oxidative stability of the nanocomposites studied. The rheological and mechanical properties of the PP-hBNN nanocomposite films were also determined depending on the particle loading ratio. Optimum particle content providing the best thermal, mechanical, and rheological properties were found to be 3% wt.
Investigation of the effect of different factors on the performance of several perovskite solar cells: a simulation study by SCAPS
Authors: MallaHasan Hasan , Onay Özlem 
Published: January 2023

The new generation of solar cells based on perovskite materials has attracted massive attention from the photovoltaic community, due to their high capability in supporting low-cost solar cell. In this study, extensive theoretical research of three types of lead-based (MAPbI3, FAPbI3 and CsPbI3) and four types of lead-free (MASnI3, FASnI3, CsGeI3, and MAGeI3) perovskite solar cells are modeled while Cu2O is used as HTL and TiO2 as ETL. The initial results show commendable performance for MAPbI3 with 24,8% efficiency, while MAGeI3 has the lowest performance (12,61%). In addition, different factors reviewed affect the performance almost similarly to the studied types of perovskites.
Penggunaan Metode Kantung Plastik Polyethylene Oklusif Sebagai Pencegahan Terjadinya Hipotermi Pada Bayi Berat Lahir Rendah (BBLR)
Authors: Aliansy Diani , Loisza Anne , Karlina Intan , Audiaturahman Wida 
Published: January 2023

Bayi Berat Lahir Rendah (BBLR) merupakan bayi yang lahir dengan berat badan < 2.500 gram tanpa memperhatikan usia kehamilan dan sangat rentan mengalami hipotermi, yang menyebabkan kematian. Kantong plastik polyethylene oklusif merupakan salah satu metode yang dikembangkan untuk mencegah hipotermi segera setelah lahir. Penelitian ini bertujuan mengetahui perbandingan efektivitas metode kantong plastik dan inkubator terhadap peningkatan suhu tubuh BBLR di Ruang Neonatus disalah satu RSUD Di Kota Sukabumi. Metode penelitian yang digunakan adalah quasi experiment design dengan pendekatan pretest-posttest control group design. Populasi adalah seluruh BBLR yang dilahirkan di RSUD Syamsudin SH. Subjek penelitian 28 BBLR dengan berat badan 1.500-2499 gram tanpa masalah pernapasan, yang dibayi menjadi kelompok metode kantung plastik dan metode inkubator. Pengambilan sampel menggunakan randomisasi blok, Penelitian dilaksanakan berdasarkan rekomendasi etik dari komite etik RS Syamsudin SH. Analisis univariat menggunakan mean, analisis bivariat perbandiang suhu tubuh menggunakan uji T Independent. Hasil penelitian didapatkan sebelum menggunakan metode kantong plastik seluruh BBLR mengalami hipotermia dengan rerata suhu tubuh sebesar 35,6⁰C dan sesudah menggunakan metode kantong plastik seluruh BBLR mengalami suhu normal dengan rerata suhu tubuh sebesar 37,1⁰C. Sebelum menggunakan inkubator seluruh BBLR mengalami hipotermia dengan rerata suhu tubuh sebesar 35,6⁰C dan sesudah menggunakan inkubator seluruh BBLR mengalami suhu normal dengan rerata suhu tubuh sebesar 36,9⁰C.Kesimpulan dari penelitian ini metode kantong plastik dapat mencegah terjadinya hipotermi pada BBLR.
Advanced strategies for production of soy-processing enzyme
Authors: Islam S. M. Mahfuzul , Ju Lu-Kwang 
Published: January 2023

Enzyme production is critical and often costly for biorefinery. It is challenging to produce enzymes with not only high titers but also proper combinations of all required activities in a single fermentation. This work aimed at improving productivity and composition of the multiple enzyme activities required for hydrolysis of complex soybean carbohydrate in a single fermentation. A previously selected Aspergillus niger strain was used for its high carbohydrases and low protease production. Strategies of fed-batch substrate addition and programmed pH-decrease rates were evaluated. Cheap soybean hull (SH) was confirmed to induce production of all necessary carbohydrases. Surprisingly, fed-batch SH addition, originally thought to sustain substrate-inducer availability and reduce feedback repression by sugars, did not increase pectinase and cellulase production significantly and even lowered the α-galactosidase production, when compared with batch fermentation having the same total SH amount (all added initially). On the other hand, the pH-decrease rate could be effectively optimized for production of complex enzyme mixtures. The best fermentation was programmed to lower pH from 7 to 4 in 84 h, at a drop rate of .0357 per h. It produced the highest pectinase (19.1 ± .04 U/mL), α-galactosidase (15.7 ± .4 U/mL), and cellulase (.88 ± .06 FPU/mL). Producing these high enzyme activities in a single fermentation significantly improves the effectiveness and economics of enzymatic soy processing, which, e.g., can hydrolyze the 30%–35% carbohydrate in soybean meal to sugars, with minimal protein degradation, to generate high-value protein-rich products and a hydrolysate as fermentation feedstock.
Customizable 3D printed perfusion bioreactor for the engineering of stem cell microenvironments
Authors: Dupard Steven J. , Garcia Alejandro Garcia , Bourgine Paul E. 
Published: January 2023

Faithful modeling of tissues and organs requires the development of systems reflecting their dynamic 3D cellular architecture and organization. Current technologies suffer from a lack of design flexibility and complex prototyping, preventing their broad adoption by the scientific community. To make 3D cell culture more available and adaptable we here describe the use of the fused deposition modeling (FDM) technology to rapid-prototype 3D printed perfusion bioreactors. Our 3D printed bioreactors are made of polylactic acid resulting in reusable systems customizable in size and shape. Following design confirmation, our bioreactors were biologically validated for the culture of human mesenchymal stromal cells under perfusion for up to 2 weeks on collagen scaffolds. Microenvironments of various size/volume (6–12 mm in diameter) could be engineered, by modulating the 3D printed bioreactor design. Metabolic assay and confocal microscopy confirmed the homogenous mesenchymal cell distribution throughout the material pores. The resulting human microenvironments were further exploited for the maintenance of human hematopoietic stem cells. Following 1 week of stromal coculture, we report the recapitulation of 3D interactions between the mesenchymal and hematopoietic fractions, associated with a phenotypic expansion of the blood stem cell populations.Our data confirm that perfusion bioreactors fit for cell culture can be generated using a 3D printing technology and exploited for the 3D modeling of complex stem cell systems. Our approach opens the gates for a more faithful investigation of cellular processes in relation to a dynamic 3D microenvironment.
Study on the molecular mechanism of anti-liver cancer effect of Evodiae fructus by network pharmacology and QSAR model
Authors: Chen Peng-Yu , Han Lin-Tao 
Published: January 2023

Introduction: Evodiae Fructus (EF) is the dried, near ripe fruit of Euodia rutaecarpa (Juss.) Benth in Rutaceae. Numerous studies have demonstrated its anti-liver cancer properties. However, the molecular mechanism of Evodiae fructus against liver cancer and its structure-activity connection still require clarification.Methods: We utilized network pharmacology and a QSAR (2- and 3-dimensional) model to study the anti-liver cancer effect of Evodiae fructus. First, by using network pharmacology to screen the active substances and targets of Evodiae fructus, we investigated the signaling pathways involved in the anti-liver cancer actions of Evodiae fructus. The 2D-QSAR pharmacophore model was then used to predict the pIC50 values of compounds. The hiphop method was used to create an ideal 3D-QSAR pharmacophore model for the prediction of Evodiae fructus compounds. Finally, molecular docking was used to validate the rationality of the pharmacophore, and molecular dynamics was used to disclose the stability of the compounds by assessing the trajectories in 10 ns using RMSD, RMSF, Rg, and hydrogen bonding metrics.Results: In total, 27 compounds were acquired from the TCMSP and TCM-ID databases, and 45 intersection targets were compiled using Venn diagrams. Network integration analysis was used in this study to identify SRC as a primary target. Key pathways were discovered by KEGG pathway analysis, including PD-L1 expression and PD-1 checkpoint pathway, EGFR tyrosine kinase inhibitor resistance, and ErbB signaling pathway. Using a 2D-QSAR pharmacophore model and the MLR approach to predict chemical activity, ten highly active compounds were found. Two hydrophobic features and one hydrogen bond acceptor feature in the 3D-QSAR pharmacophore model were validated by training set chemicals. The results of molecular docking revealed that 10 active compounds had better docking scores with SRC and were linked to residues via hydrogen and hydrophobic bonds. Molecular dynamics was used to show the structural stability of obacunone, beta-sitosterol, and sitosterol.Conclusion:Pharmacophore 01 has high selectivity and the ability to distinguish active and inactive compounds, which is the optimal model for this study. Obacunone has the optimal binding ability with SRC. The pharmacophore model proposed in this study provides theoretical support for further screening effective anti-cancer Chinese herbal compounds and optimizing the compound structure.
Research trends on the relationship between gut microbiota and colorectal cancer: A bibliometric analysis
Authors: Wu Weigen , Ouyang Yaobin , Zheng Pan , Xu Xinbo , He Cong , Xie Chuan , Hong Junbo , Lu Nonghua , Zhu Yin , Li Nianshuang 
Published: January 2023

BackgroundColorectal cancer (CRC)is the third most common cancer in the world and the second leading cause of cancer-related deaths, and over the past two decades, many of these researchers have provided a substantial amount of important information on the role of gut microbes in the development and progression of CRC. A causal relationship between the presence of specific microorganisms and CRC development has also been validated. Although a large number of papers related to this area have been published, no bibliometric study has been conducted to review the current state of research in this area and to highlight the research trends and hotspots in this area. This study aims to analyze the current status and future research trends of gut microbiota and CRC through bibliometric analysis.MethodsPublications from 2001 to 2022 were retrieved from the Web of Science Core Collection database and screened according to inclusion criteria. VOSviewer and CiteSpace software were used to visualize the research trends in this field, including the analysis of title, country, institution, author, number of publications, year of publication, number of citations, journal, and H-index.ResultsA total of 863 studies were eventually identified, and the articles retrieved were cited an average of 44.85 times each. The number of publications on this topic has been increased steadily since 2011. China and the USA have made the largest contribution in the field. FRONTIERS IN MICROBIOLOGY is the top productive journal with 26 papers, and Gut journal has the highest average citation (167.23). Shanghai Jiao Tong University is the most contributive institution. Professor Yu J, Sung, Joseph J. Y and Fang JY are the most productive authors in this field. Keyword co-occurrence analysis showed that the terms of “Gut Microbiota”, “Colorectal Cancer”, “Inflammation”, “Probiotic” and “Fusobacterium Nucleatum” were the most frequent, which revealed the research hotpots and trends in this field.ConclusionsThere has been a growing number of publications over the past two decades according to the global trends. China and the USA still maintained the leading position in this field. However, collaboration between institutions needs to be strengthened. It’s commended to pay attention to the latest hotspots, such as “F. nucleatum” and “probiotics”. This bibliometric analysis evaluates the scope and trends of gut microbiota and CRC, providing a useful perspective on current research and future directions for studying the link between the gut microbiota and CRC.
Heptadecanoic acid and pentadecanoic acid crosstalk with fecal-derived gut microbiota are potential non-invasive biomarkers for chronic atrophic gastritis
Authors: Gai Xiao , Qian Peng , Guo Benqiong , Zheng Yixin , Fu Zhihao , Yang Decai , Zhu Chunmei , Cao Yang , Niu Jingbin , Ling Jianghong , Zhao Jin , Shi Hailian , Liu Guoping 
Published: January 2023

BackgroundChronic atrophic gastritis (CAG), premalignant lesions of gastric cancer (GC), greatly increases the risk of GC. Gastroscopy with tissue biopsy is the most commonly used technology for CAG diagnosis. However, due to the invasive nature, both ordinary gastroscope and painless gastroscope result in a certain degree of injury to the esophagus as well as inducing psychological pressure on patients. In addition, patients need fast for at least half a day and take laxatives.MethodsIn this study, fecal metabolites and microbiota profiles were detected by metabolomics and 16S rRNA V4-V5 region sequencing.ResultsAlteration of fecal metabolites and microbiota profiles was found in CAG patients, compared with healthy volunteers. To identify the most relevant features, 7 fecal metabolites and 4 microbiota were selected by random forest (RF), from A and B sample sets, respectively. Furthermore, we constructed support vector machines (SVM) classifification model using 7 fecal metabolites or 4 gut microbes, or 7 fecal metabolites with 4 gut microbes, respectively, on C sample set. The accuracy of classifification model was 0.714, 0.857, 0.857, respectively, and the AUC was 0.71, 0.88, 0.9, respectively. In C sample set, Spearman’s rank correlation analysis demonstrated heptadecanoic acid and pentadecanoic acid were signifificantly negatively correlated to Erysipelotrichaceae_UCG-003 and Haemophilus, respectively. We constructed SVM classifification model using 2 correlated fecal metabolites and 2 correlated gut microbes on C sample set. The accuracy of classification model was 0.857, and the AUC was 0.88.ConclusionTherefore, heptadecanoic acid and pentadecanoic acid, crosstalk with fecal-derived gut microbiota namely Erysipelotrichaceae_UCG-003 and Haemophilus, are potential non-invasive biomarkers for CAG diagnosis.
An acoustic study on character voices of dominators and subordinates: A case study on male characters in Empresses in the Palace
Authors: Liu Wen , Zhang Xinyi , Liang Changwei 
Published: January 2023

IntroductionVoice has been used to project identity in dubbing, in order to auditory portray appropriate role images in TV dramas. This study investigates the character voices of leading male characters in Empresses in the Palace.MethodsDifferent acoustic characteristics of character voices and matching relation between acoustics and role images are explored by comparing F0, CPP, harmonic amplitude differences of speech spectrum.ResultsThe voice quality of characters is related to their relative social status. The subordinates usually adopt a higher pitch or breathy voice, while the dominators use a lower pitch or modal/creaky voice. In addition, CPP, F0, and H1-A3 are the key acoustic indicators to distinguish character voices.DiscussionThese results reveal the acoustic characteristics of character voices of certain types, as well as provide guidance for dubbing vividly.
Systolic blood pressure as the mediator of the effect of early menarche on the risk of coronary artery disease: A Mendelian randomization study
Authors: Fan Hsien-Yu , Huang Yen-Tsung , Chen Yun-Yu , Hsu Justin BoKai , Li Hung-Yuan , Su Ta-Chen , Lin Hung-Ju , Chien Kuo-Liong , Chen Yang-Ching 
Published: January 2023

BackgroundMenarche timing may not be directly associated with the risk of coronary artery disease (CAD). Therefore, we investigated the roles of metabolic factors in explaining the effect of age at menarche on CAD risk.MethodsWe identified women with age at menarche and CAD by using three analytical methods: Mendelian randomization (MR), logistic regression analysis, and Cox proportional hazard regression. The first two analyses were performed in the Taiwan Biobank (N = 71,923) study, and the last analysis was performed in the Chin-Shan Community Cardiovascular Cohort study (N = 1,598). We further investigated the role of metabolic factors in mediating the effect of age at menarche on CAD risk by using three complementary methods with mediation analyses.ResultsOne standard deviation of earlier age at menarche was associated with a 2% higher CAD risk [odds ratio = 1.02, 95% confidence interval (CI) = 1.001–1.03] in the MR analysis, an 11% higher risk (odds ratio = 1.11, 95% CI = 1.02–1.21) in the logistic regression analysis, and a 57% higher risk (hazard ratio = 1.57, 95% CI = 1.12–2.19) in the Cox proportional hazard regression. All the analyses consistently supported the role of systolic blood pressure in mediating this effect. The MR results indicated that 29% (95% CI = 26%–32%) of the effect of genetically predicted earlier age at menarche on CAD risk was mediated by genetically predicted systolic blood pressure.ConclusionThe results obtained using different analytical methods suggest that interventions aimed at lowering systolic blood pressure can reduce the cases of CAD attributable to earlier age at menarche.
Totally endoscopic aortic valve replacement: Techniques and early results
Authors: Gu Wenda , Zhou Kan , Wang Zhenzhong , Zang Xin , Guo Haijiang , Gao Qiang , Teng Yun , Liu Jian , He Biaochuan , Guo Huiming , Huang Huanlei 
Published: January 2023

ObjectiveTo demonstrate the technical details of total endoscopic aortic valve replacement using a standard prosthesis, compare the clinical effect and safety of endoscopic aortic valve replacement and traditional aortic valve replacement.MethodsFrom 2020 to 2021, 60 consecutive patients underwent elective isolated aortic valve replacement (AVR). They were divided into two groups: the total endoscopic AVR group (TE-AVR group, 29 patients, nine women, aged 51.65 ± 11.79 years), and the traditional full-sternotomy group (AVR group, 31 patients, 13 women, aged 54.23 ± 12.06 years). Three working ports were adopted in the TE-AVR procedure.ResultsNo patient died in either group. The cardiopulmonary bypass (CPB) time and aortic cross-clamp (ACC) time in the TE-AVR group were longer than those in the AVR group (CPB time: 177.6 ± 43.2 vs. 112.1 ± 18.1 min, p &lt; 0.001; ACC time: 118.3 ± 29.7 vs. 67.0 ± 13.2 min, p &lt; 0.001). However, the mechanical ventilation duration (14.2 ± 9.3 vs. 24.0 ± 18.9 h, p = 0.015) and postoperative hospital stay (6.0 ± 1.7 vs. 8.0 ± 4.5 days, p = 0.025) were shorter in patients of TE-AVR group than those of AVR group. Although the ICU stay (55.1 ± 26.9 vs. 61.5 ± 44.8 h, p = 0.509) and post-operative chest drainage of the first 24 h (229.8 ± 125.0 vs. 273.2 ± 103.2 ml, p = 0.146) revealed no statistical difference, there was a decreasing trend in the TE-AVR group. Among the patients of the TE-AVR group, two patients were converted to thoracotomy because of mild to moderate paravalvular leakage identified by intraoperative transesophageal echocardiography.ConclusionTotal endoscopic aortic valve replacement is safe and feasible, with less trauma and quicker recovery.
Meridional circulation dominates the record-breaking “Dragon Boat Water” rainfall over south China in 2022
Authors: Cheng Jianbo , Zhao Yuheng , Zhi Rong , Feng Guolin 
Published: January 2023

During the “Dragon Boat Water” season in 2022, record-breaking anomalous rainfall occurred over South China (SC). In this study, the causes of anomalous rainfall are investigated by using the novel moisture budget equation of three-pattern circulations. The results show that the anomalous rainfall over SC caused by the horizontal, meridional, and zonal circulations was −10 mm, 168 mm, and 45.3 mm, which contribute −5%, 86%, and 23% of the actual rainfall anomaly (195.1 mm), respectively, suggesting that the meridional circulation contributes most to anomalous rainfall, followed by zonal circulation, and horizontal circulation contributes negatively. Further analysis based on the three-pattern decomposition of the global atmospheric circulation shows that the spatial configuration of the anomalous horizontal circulation and vertical vorticity provides the background for generating the anomalous divergence and convergence of meridional and zonal circulations and further anomalous vertical velocity of the meridional and zonal circulations, ultimately resulting in anomalous rainfall.