bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genetic parameters and promising provenances and progenies for enhanced silvicultural traits in Eremanthus erythropappus
Authors: Almeida Rodolfo Soares , Oliveira Lavinia Barbosa , Santos Heloisa Guimaraes , Júnior Adelson Lemes Silva , Cunha Fernanda Leite , Melo Lucas Amaral , Possato Ernani Lopes 
Published: September 2023

Abstract

Eremanthus erythropappus, a species of economic importance for α-bisabolol production, has great potential for genetic improvement. However, limited knowledge on genetic parameters during the exploitation of commercial plantations hampers its progress. In this study, we estimated genetic parameters and correlations for silvicultural traits in a provenance and progenies test of E. erythropappus at 11 years of age, aiming to identify promising provenances and families. The experiment, conducted in Baependi, involved five provenances and 116 half-sib families in a complete randomized block design. Height (H), diameter at breast height (DBH), survival (SOB), and volume (Vol) were measured, and the REML/BLUP mixed model approach was used to estimate genetic parameters. Our results revealed significant genotype-level effects for all traits, except H at the provenance level. Narrow sense heritability ranged from 0.05 (SOB) to 0.17 (DBH), suggesting a substantial influence of environmental factors. Genotypic variation surpassed that of provenances, and positive phenotypic and genotypic correlations between growth traits were observed, ranging from moderate to strong. Notably, the provenances Itabirito and Delfim Moreira exhibited outstanding performance in terms of DBH and Vol. Furthermore, families 4, 6, 37, 118, and 124 emerged as top contenders for H, DBH, and Vol. Despite low heritability, selection strategies within and between provenances and families for silvicultural traits are viable. Importantly, high phenotypic and genotypic correlations allow for indirect selection, thus streamlining assessment efforts. These findings advance our understanding of genetic parameters providing valuable insights for the genetic improvement of E. erythropappus, fostering its sustainable utilization in various industries.
Effect of wooden floorboards on the vibration of timber floor
Authors: Hassan Osama 
Published: September 2023

Abstract
This study is aimed at investigating those parameters related to timber flooring that can affect the acceptability of vibration behaviour of a timber floor in a residential building in view of the criteria stated in Eurocode EC5. The timber floor investigated is made of OSB/3 floorboards and timber joists. The parameters that are investigated in this study are thickness of flooring, floor joist span, joist spacing and connection of floorboards to the joists. In this context, two cases are considered. First: the flooring is nailed or screwed to the joists and no composite action or interaction is obtained between joists and floorboards. Second: the flooring is glued sufficiently to the joists and full interaction is obtained. The result suggests that glued floorboards perform much better with respect to natural frequency, static deflection and peak floor velocity than nailed or screwed floorboards. In almost all cases of glued floorboards, the result complies fully with the Eurocode 5 design vibration requirements. However, as floor lengths increase, the static deflection will increase beyond the allowable limit, especially for relatively thin floor panels and relatively widely spread joists. For both cases, increasing floorboards thickness and decreasing the joist span by adding more beams can yield even better results to satisfy the requirement of vibration comfort.
The Chain Mediating Effect of Socialist Core Values and Positive Psychological Capital on Relationship Between Meaning in Life and Crisis Vulnerability
Authors: LIU Qin , CHANG Renjie , Peng Junjie 
Published: September 2023

Abstract
Objective: To explore the relationship between the sense of meaning in life and crisis vulnerability of undergraduate nursing student and the chain mediating effect of socialist core value identification and positive psychological capital on the relationship between the two.
Methods: A total of 330 undergraduate nursing students (M±SD = 19.68±1.31 years old) from traditional Chinese medicine colleges in Yunnan ethnic minority areas were measured bythe Sense of Life Scale, Socialist Core Values Identity Scale, Sense of Life Scale and Crisis Vulnerability Questionnaire.
Results: The sense of meaning in life was negatively correlated with crisis vulnerability, positively correlated with socialist core values identification and positive psychological capital, negatively correlated with crisis vulnerability, positively correlated with socialist core values identification and positive psychological capital, and positively correlated with socialist core values identification. The chain mediation effect analysis shows that the sense of meaning in life can predict crisis vulnerability through three indirect pathways: the mediating effect of socialist core value identification, the mediating effect of positive psychological capital, and the chain mediating effect of socialist core values and positive psychological capital.
Conclusion: The sense of meaning in life may be a remote variable of the crisis vulnerability of undergraduate nursing students, which can reduce individual crisis vulnerability by enhancing the level of socialist core value identification and positive psychological capital.
GPR-RF: A Network Attack Traffic Detection Method Based on Random Forest and Bayesian Optimization
Authors: Du Xiaoyu , Lin Lvzhou , Han Zhijie , Zhang Changtao , Du Ying 
Published: September 2023

Abstract
Intrusion detection systems can identify intrusion processes which are attempting to intrude, in the process of intruding, or have already occurred.Intrusion detection is a proactive defense approach. Intrusion detection system models built by machine learning are very sensitive to hyper-parameter settings, and different combinations of hyper-parameters can dramatically affect the model's capabilities. In previous work, finding hyperparameters corresponding to advanced models is a difficult task. In order to deal with the huge amount of network traffic data, we here propose the Gaussian Process Regression and Random Forest (GPR-RF) method, which uses Bayesian optimization of Gaussian process regression to find more appropriate combinations of Random Forest hyperparameters, and realizes the following two advantages: 1. The accuracy of the model is greatly improved compared to the traditional methods. 2. The method can quickly converge to better configurations. Among several methods compared, our method performs best in both aspects.
Onion (Allium cepa L.) flavonoids extract ameliorates osteoporosis facilitating osteoblast proliferation and differentiation, and inhibiting RANKL-induced osteoclastogenesis
Authors: Zhang Danyang , Wang Xiaoyu , Sun Kezhuo , Guo Jianli , Zhao Jia , Dong Yuesheng , Bao Yongming 
Published: September 2023

Abstract
Osteoporosis, a bone metabolic disease, is a global chronic health problem. Flavonoids, a group of natural active compounds widely existing in vegetables, fruits, beans and cereals, were reported to be anti-osteoporosis. Onion is a common vegetable rich in flavonoids. In this study, bone mineral density (BMD) was increased significantly after taking onion flavonoids extract (OFE) orally in an ovariectomized (OVX)-induced rat model, the trabecular structure and serum biomarkers were both improved, with effects similar to estradiol. Compared with the OVX rats, the contents of E2, calcium and phosphorus in the serum of rats were enhanced, but ALP and Trap levels in serum were decreased. In addition, the activity of on bone health was assessed by human osteoblast-like cells MG-63 and osteoclast precursor Raw 264.7 cells in vitro as well. After treated with OFE, MG-63 cells proliferation and mineralization were promoted, and alkaline phosphatase (ALP) activity and mRNA expression of OPG/RANKL were increased significantly. Moreover, RANKL-induced osteoclastogenesis of Raw 264.7 cells and osteoclast activity were inhibited with decrease of tartrate-resistant acid phosphatase (TRAP) activity, and mRNA expression of remarkable enzymes was down-regulated in cells. Furthermore, it was demonstrated that OFE regulated activity of osteoblast mainly via the OPG/RANKL signaling pathway and osteoclastogenesis. The results provided evidence a new model of dietary supplements for preventing osteoporosis.
IL-12/IFN-γ axis drives skin wound healing via innate defense mechanisms against bacterial invasion in teleost fish
Authors: Qiu Xingyang , Yang Mu , Sun Hao , Liu Jiaxi , Wang Xinyan , Zhang Anying , Yang Kun , Zhou Hong 
Published: September 2023

Abstract
Objective and design
IL-12 is a well-recognized pro-inflammatory cytokine with multi-functions in participating mammalian innate immunity, but little is known regarding the details for protecting skin barrier damage in lower vertebrates. The aim of this study was to evaluate the effects and mechanisms of IL-12 and its key effectors in promoting skin wound repair in teleosts.
Material or subjects
Recombinant gcIL-12BB (rgcIL-12BB) was employed to investigate IL-12 roles in teleost skin wound healing. Meanwhile, the regulatory effects of rgcIL-12BB on re-epithelialization, inflammation and bacterial clearance at lesion sites were explored. Furthermore, the role of increased IFN-γ and recruited neutrophil in skin wound were uncovered. Finally, the mechanism of neutrophil bacterial clearance triggered by IFN-γ was also elucidated.
Results
The rgcIL-12BB could promote wound healing, reduce bacterial invasion, and significantly promote epithelial cell proliferation and migration. Moreover, as the main effector of IL-12BB, IFN-γ was observed to exhibit bactericidal activities mainly via recruiting and stimulating autophagic neutrophils in teleosts. In line with findings in mammals, the grass carp guanylate-binding protein 1 (gcGBP1) acts as a downstream effector of the IL-12/IFN-γ axis that interacts with autophagy-related proteins LC3B and P62, which are involved in gcIFN-γ-induced autophagy.
Conclusion
Collectively, our results highlighted an intrinsic mechanism whereby the IL-12/IFN-γ axis triggers the host's innate defense against bacterial infection, thereby improving skin wound healing in teleosts.
3D printing technology combined with personalized customization of steel plates for the treatment of complex distal intra-articular fractures of the trimalleolar ankle
Authors: Liang Hairui , Zhang He , Chen Beibei , Yang Lei , Xu Rongda , Duan Siyu , Cai Zhencun 
Published: September 2023

Abstract
This study investigated the effectiveness of 3D printing technology in combination with personalized custom-made steel plates in the treatment of complex distal intra-articular trimalleolar fractures, with the aim of providing a new approach to improve ankle joint function in patients. The 48 patients with complex distal intra-articular tri-malleolar fractures included in the study were randomly divided into two groups: the personalized custom-made steel plate group (n = 24) and the conventional steel plate group (n = 24). A comparison was made between the two groups in terms of preoperative preparation time, hospitalization duration, surgical time, fracture reduction and internal fixation time, intraoperative fluoroscopy instances, surgical incision length, fracture healing time, follow-up duration, degree of fracture reduction, ankle joint functional recovery, and the occurrence of complications. The personalized steel plate group exhibited longer preoperative preparation time and hospitalization duration compared to the conventional steel plate group (p < 0.001). However, the personalized steel plate group demonstrated significantly shorter surgical duration, time for fracture reduction and internal fixation, reduced intraoperative fluoroscopy frequency, and a shorter overall surgical incision length (p < 0.001). Both groups displayed similar fracture healing times and follow-up durations (p > 0.05). The personalized steel plate group showed a higher rate of successful fracture reduction (87.5% vs. 79.2%, p > 0.05) and a lower incidence of complications (8.3% vs. 20.8%, p = 0.22), although these differences did not reach statistical significance. Furthermore, the personalized steel plate group exhibited superior ankle joint function scores during follow-up compared to the conventional steel plate group (p < 0.05). By utilizing 3D printing technology in conjunction with personalized custom-made steel plates, personalized treatment plans are provided for patients with complex comminuted tri-malleolar ankle fractures, enabling safer, more efficient, and satisfactory orthopedic surgeries.
Ferulic acid alleviates inflammatory manifestations in atopic dermatitis through modulation of the TRPV1/HMGB1 signaling pathway
Authors: Wang Hui-Min , Lee Yi-Chieh , Chen Chung-Yi , Chang Jui-Jen , Hung Huei-Cheng , Tsai Pei-Chien 
Published: September 2023

Abstract
Atopic dermatitis (AD) is a prevalent skin ailment in Asia, and the currently available clinical interventions provide only limited respite while potentially leading to undesired or severe side effects. This investigation explores ferulic acid's potential as an innovative and efficacious remedy for AD. Ferulic acid, recognized for its diverse pharmacological and biological attributes, underwent evaluation through both cellular and in vivo studies. The outcomes revealed that ferulic acid adeptly mitigated the inflammatory retort associated with AD by quelling the activation of the TRPV1 and HMGB1 signaling pathways—both tied to the Transient Receptor Potential Cation Channel, Subfamily V, Member 1 (TRPV1) and High Mobility Group Protein 1 (HMGB1). In a BALB/c mouse model, ferulic acid demonstrated significant amelioration of AD symptoms prompted by DNCB, including the reduction of skin barrier impairment, diminished ear and skin epidermal thickness, curbed mast cell infiltration, and decreased spleen and lymph node dimensions. These findings underscore the potential of ferulic acid as a viable treatment avenue for AD. The multifaceted attributes of ferulic acid, its confirmed pharmacological and biological merits, and its demonstrated effectiveness in assuaging AD's inflammatory responses, as validated by cellular and in vivo investigations, collectively propose its significant promise as a compelling substitute in the therapeutic landscape for AD. Running head: Ferulic acid inhibits inflammation in AD
Electrospinning of poly(ethylene oxide)/glass hybrid nanofibers for anticounterfeiting encoding
Authors: El-Newehy Mohamed H. , Aldalbahi Ali , Thamer Badr M. , Abdulhameed Meera Moydeen 
Published: September 2023

Abstract
The use of photochromism to increase the credibility of consumer goods has shown great promise. In order to provide mechanically dependable anticounterfeiting nanofibers, it has also been critical to improve the engineering processes of authentication patterns. Mechanically robust and photoluminescent electrospun poly(ethylene oxide)/glass (PGLS) nanofibers (150-350 nm) integrated with nanoparticles of lanthanide-doped aluminate (NLA; 8-15 nm) were developed using electrospinning technology for anti-counterfeiting purposes. The provided nanofibrous films change color from transparent to green when illuminated with ultraviolet light. By delivering NLA with homogeneous distribution without aggregations, we were able to keep the nanofibrous film transparent. When excited at 365 nm, the NLA@PGLS nanofibers displayed emission intensity at 517 nm. The hydrophobicity of NLA@PGLS nanofibers was improved by raising the pigment concentration. After being triggered by ultraviolet light, NLA@PGLS showed quick and reversible photochromism without fatigue. It has been shown that the suggested method can be applied to reliably produce a variety of anti-counterfeiting materials.
Landscape Naturalness Scenarios Modeling for the Juréia-Itatins Protected Areas Mosaic, State of São Paulo, Brazil
Authors: Guilhem Andres Caseiro , Fushita Angela Terumi , Francisco Richard Fonseca 
Published: September 2023

Abstract

Due to its biodiversity, ecosystem services offered, and deforestation experienced since the 16th century, there are several protected areas in Atlantic Forest, such as the Juréia-Itatins Protected Areas Mosaic (JIPAM), state of São Paulo, Brazil. Illegal deforestation in the JIPAM and surroundings have been increasing, caused by urban and agricultural expansion. Landscape naturalness scenarios of JIPAM and surroundings for 2050 year were simulated, considering the periods 1985–2002 and 2002–2019, which correspond, respectively, to the scenarios before and after the creation of the JIPAM and National System of Protected Areas (NSPA). The landscape naturalness was evaluated by generating Distance to Nature index (D2N) maps for years 1985, 2002 and 2019, which was used as input data in simulation. The forecasting of both scenarios was conducted using cellular automata, weights of evidence and Markov chain, in Dinamica EGO platform. Both projections indicated that there would be a slight decrease in landscape naturalness. However, the scenario with JIPAM and NSPA can be considered the most effective in guiding the study area toward a conservation profile, as it would contribute to a reduction of approximately 32% of non-natural areas located within mosaic, in relation to another scenario. The NSPA and the creation of the JIPAM have contributed to maintain the study area naturalness, reducing losses in landscape naturalness. Nevertheless, municipal planning and the JIPAM management plans should consider urban and agricultural expansion and access roads as important drivers of loss of landscape naturalness, triggering deforestation and biodiversity damages.
New Water-Stainless Steel Rod-Plate Heat Pipe: Model and Experiments
Authors: Araújo Elvis Falcão , Mera Juan Pablo Flóres , Cisterna Luis H. R. , Mantelli Márcia Barbosa Henriques 
Published: September 2023

Abstract

This work proposes a novel flat heat pipe technology, namely the rod-plate heat pipe, formed by the diffusion bonding of a set of parallel rods, of around 8 mm diameter, between flat plates of approximately 500 x 60 x 2 mm3. This design is inspired by the mini wire-plate heat pipe concept. This work is the first in the literature to apply this technology to large size heat pipes. A theoretical model is devised and used to predict the fluid distribution along the heat pipe, detect regions of flooding and dry-out and determine the best charging volume. Experiments are performed with a stainless-steel device operating in horizontal orientation with water as working fluid. Electrical cartridge resistances play the role of the evaporator heat source, while the condenser is cooled by either natural convection or heat exchangers linked to a thermal bath. The thermal resistances of the water charged device cooled by natural convection are very low, with a minimum of 0.046 ºC/W, for 88.59 W for heat input. Moreover, the operation temperature increases with heat input up to 326.56 ºC for a heat load of 191.40 W. The thermal resistances of the heat pipe cooled by the heat exchanger are also very low, with a minimum of 0.144 ºC/W at 177.49 W heat transport rate, for a 50 ºC thermal bath temperature. The theoretical results and data obtained so far corroborate the feasibility of this technology, with devices able to transfer up to 22.71 W per groove.
In situ polymerization of hydrogel electrolyte on electrode enabling the flexible all-hydrogel supercapacitors with low-temperature adaptability
Authors: Zhang Yijing , Sun Yue , Nan Jingya , Yang Fusheng , Wang Zihao , Li Yuxi , Wang Chuchu , Chu Fuxiang , Liu Yupeng , Wang Chunpeng 
Published: September 2023

Abstract

All-hydrogel supercapacitors are emerging as promising power sources for next-generation wearable electronics due to their intrinsically mechanical flexibility, eco-friendliness, and enhanced safety. However, the insufficient interfacial adhesion between electrode and electrolyte and the frozen hydrogel matrices at subzero temperatures largely limit the practical applications of all-hydrogel supercapacitors. Here, we report an all-hydrogel supercapacitor with robust interfacial contact and anti-freezing property, which is fabricated by in situ polymerizing hydrogel electrolyte onto hydrogel electrode. The robust interfacial adhesion is developed by the synergistic effect of tough hydrogel matrix and topological entanglements. Meanwhile, the incorporation of ZnCl2 in the hydrogel electrolyte prevents water solvents from freezing and endows the all-hydrogel supercapacitor with mechanical flexibility and fatigue resistance across a wide temperature range of 20°C to − 60°C. Such all-hydrogel supercapacitor demonstrates satisfactory low-temperature electrochemical performance, delivering high energy density of 11 mWh cm–2 and excellent cycling stability with capacitance retention of 99% over 5000 cycles at − 40°C. Notably, the fabricated all-hydrogel supercapacitor can endure dynamic deformations and operate well under 2000 tension cycles even at − 40°C, without delamination and electrochemical failure. This work offers a promising strategy for flexible energy storage devices with low-temperature adaptability.
Deep Learning Model for Automated Detection and Classification of Central Canal and Neural Foraminal Stenosis at Cervical Spine MRI
Authors: Zhang Enlong , Yao Meiyi , Li Yuan , Wang Qizheng , Song Xinhang , Chen Yongye , Liu Ke , Zhao Weili , Xing Xiaoying , Zhou Yan , Meng Fanyu , Ouyang Hanqiang , Chen Gongwei , Jiang Liang , Lang Ning , Jiang Shuqiang , Yuan Huishu 
Published: September 2023

Abstract

Objectives: Developing a Deep learning (DL) model to automatically detect and classify cervical canal and neural foraminal stenosis on cervical spine MRI can improve the accuracy and efficiency of its diagnostic.
Methods: A method for cervical spinal stenosis was proposed based on the DL model, consisting of region of interest (ROI) detection and cascade prediction. First, three part-specific convolutional neural networks were used to detect the ROIs in different parts of cervical MRI images. Then, the cascade prediction of stenosis categories was performed to obtain the results of stenosis level and position on each slice of the patients. Finally, in the testing, the results were fused to obtain a patient-level diagnostic report. The performance was evaluated with the metrics of accuracy (ACC), area under curve (AUC), sensitivity, specificity, F1 Score, and diagnosis time of the DL model, as well as recall rate for ROI detection localization.
Results: The average recall rate of ROIs localization reached 89.3% (neural foramen), and 99.7% (central canal) under the five-fold cross-validation of our DL model. In dichotomous classification (normal or mild vs moderate or severe), ACC and AUC of the DL model were very close to the level of radiologists, and the F1 score (84.8%) of the DL model was slightly higher than that of radiologists (83.8%) at central canal.
Conclusion: The DL model showed comparable performance with subspecialist radiologists for detection and classification of the central canal and neural foraminal stenosis at cervical spine MRI with significant time-saving.