bluuebunny/crossref_metadata_2025_split huggingface dataset:
ADHERENCE TO TREATMENT IN HYPERTENSIVE ADULTS: RELATIONSHIP WITH SOCIAL SUPPORT, ANXIETY AND DEPRESSION
Authors: Martinez Vanessa Carolina Romero , Silva Eglé , Bermudez Greily , Bracho Mayela , Esis Carlos , Calmón Gustavo , Madueño Freddy 
Published: June 2023

Objective:
This study examined the relationship between Social Support (SS) Anxiety (A) Depressión (D) with adherence to treatment (AT) in hypertensive adults.

Design and method:
There were 1582 hypertensive adults, males (n = 404) and females (n = 1178), age mean = 72 years, (SD = 12, 57). The Morisky–Green test evaluated compliant and non-compliant, DUKE test evaluated affective social support (ASS) and confidential social support (CSS), Zung Anxiety scale: Minimum anxiety (MiA), Moderate anxiety MoA) and Severe anxiety (SeA) and Zung Depression scale: Non depression (NoD) Minimum Depression (MiD) and Moderate- Severe Depression (MosD), all applied in one day doctor's visit.

Results:
The means and standard deviations for Systolic Blood Pressure of hypertensive adults was: 158,91 ± 29,82; for Diastolic Blood Pressure of hypertensive adults was 74,43 ± 12,79. Hypertensive adults compliant 20,3% and hypertensive adults non-compliant 79,7%. Good ASS support was 4.1%; bad ASS was 95.9%. Good CSS was 3.4% and 96.6% for bad CSS. MiA 35.6%; MoA 30% and SeA 34.4%. NoD 29.3%; MiD 63.7% and MosD 7%. The Rho Spearman correlation showed a significant correlation between AT and ASS (Rho Spearman: r = ,120**/ p = ,000); AT and CSS (Rho Spearman: r = ,113**/ p = ,000); AT and A (Rho Spearman: r = ,141**/ p = ,000); AT and D (Rho Spearman: r = ,132**/ p = ,000).

Conclusions:
The results provide evidence of a relationship between AT and ASS, CSS, A, D in hypertensive adults, indicating that social support and mood are important variables that must be evaluated when measuring adherence to treatment and seeking strategies to improve them.
THE EFFECT OF TEXT MESSAGES BY CELL PHONE IN THE CONTROL OF HYPERTENSION: A RANDOMIZED CLINICAL TRIAL
Authors: Coelho Juliana Chaves , Lee Renata Jae Won , Silva Giovanio Vieira , Drager Luciano Ferreira , Pierin Angela Maria Ger 
Published: June 2023

Objective:
To compare the effects of texting by cell phone plus standard usual guidance for hypertension versus standard usual guidance alone, on blood pressure control, among hypertensive patients undergoing outpatient treatment.

Design and method:
Randomized controlled clinical trial, composed of two groups: Intervention Group, who received SMS text messages twice a week for 10 weeks; and Comparison Group, who received the usual care. Both groups received an educational pamphlet about the hypertension. The primary outcome was BP control by office blood pressure measurement (OBPM; <140/90 mmHg) or by daytime Ambulatory Blood Pressure Monitoring (ABPM; <135/85 mmHg). Adherence to treatment was assessed indirectly using the 4 item Morisky Medication Adherence Scale and, directly, by assessing antihypertensive drugs in the urine, using a high-performance liquid chromatography technique associated with mass spectrometry. The significance level was 5%.

Results:
In the study, 178 patients were randomized, (90 in the Intervention Group and 88 in the Comparison Group). The sample was 60 (10) years old, women (63.8%), non-white (58.9%) and married (54.6%). The hypertensive patients were classified as having high cardiovascular risk (77.3%). The result of the intervention effect showed that there was no difference between the Intervention Group and Comparison Group (RR = 1.05; 95%CI = 0.75-1.47, and RR = 1.23; 95%CI = 0.87-1.74, respectively) in the control of OBPM, or by the daytime ABPM. However, in the Intervention Group and Comparison Group, respectively, there was a mean reduction in BP (-8.6 and -7.3 mmHg in systolic OBPM and -2.19 mmHg and -2.09 mmHg in systolic daytime ABPM); and increase in the BP control by the OBPM (19.8% to 36.0% and 19.7% to 38.2%) and daytime ABPM (38.6% to 42.5% and 41.3% to 52.2%); and in the assessment of adherence indirectly (45.3% to 69.4% and 57.1% to 59.2%). In the assessment of adherence directly, there was little difference between the groups and the two moments evaluated.

Conclusions:
The effect of texting by cell phone was similar to usual treatment for hypertension on BP control. On the other hand, both groups improved BP control and increased adherence to treatment.
A SPECIFIC 3 MONTHS-PROGRAM TO IMPROVE NON-ADHERENCE IN UNCONTROLLED HYPERTENSION IMPROVES BLOOD PRESSURE CONTROL AND ASSOCIATED ORGAN DAMAGE (ATHAN CLINICAL TRIAL)
Authors: Oliveras Anna , Hernández Juanjo , Camps Carme , Fontdevila Laia , Vega Victoria , Vinyoles Ernest , Galceran Isabel , Crespo Marta , Vazquez Susana 
Published: June 2023

Objective:
To evaluate whether a specific 3-month(m) action plan to improve therapeutic adherence in patients with uncontrolled hypertension on ◊ 2 drugs results in a decrease in BP and whether this is maintained at 12m. Secondly, to assess if this correlates with an improvement in subclinical organ damage.
Design and Method: Prospective, randomized clinical trial where patients attended consecutively in a Hypertension Unit with ambulatory 24h-BP ◊130/80 mmHg despite receiving at least 2 antihypertensive drugs and with therapeutic non-compliance confirmed by the determination of antihypertensive drugs in the urine, were randomized (1:1) to receive a specific 3-month program to improve adherence (INT = intervention) or routine follow-up (C = control). Antihypertensive treatment was not modified, but beyond 3m all patients received usual care. Before randomization, and at 3m and 12m, urinary screening for antihypertensive drugs and albuminuria, and 24h-ambulatory BP monitoring were determined.

Results:
Forty-six patients were randomized. At 3m, mean (95%CI) baseline-adjusted BP differences (INT vs. C) were -14.7 mmHg (-5.4 to -24.1), p = 0.001 and -10.0 mmHg (-3.9 to -16.2), p<0.001 for 24h-SBP and 24h-DBP, respectively. The INT group maintained the BP decrease at 12m. vs. baseline: mean(95%CI) variation of 24h-SBP = -16.1 mmHg (-22.8 to -9.4), p<0.001 and variation of 24h-DBP = -7.8 (-12.8 to -2.7), p = 0.002. In the INT group, the percentage of non-detected antihypertensive drugs decreased compared to baseline: median [IQR]: 40% [20-85.7], 0% [0-25], and 18.3 % [0-40] at baseline, 3m and 12m respectively; Z = -3.295 (p<0.001) and Z = -3.055 (p = 0.002) for changes at 3m and 12m, respectively. Albuminuria (median [IQR]) decreased in the INT group: 27.1 mg/g [11.2-116.2] and 22.4 mg/g [6.4-91.9] at baseline and 12m, respectively (Z = -2.207, p = 0.027). At 12m, variation of albuminuria correlated with variation of 24h-BP but not with variation of percentage of non-detected antihypertensive drugs.

Conclusions:
a 3-month specific nursing intervention to improve therapeutic adherence results in improved BP control in patients with inadequate therapeutic compliance. This improvement continues beyond the completion of this program. Decreased BP correlates with a regression of albuminuria.
PRESCRIPTION OF SINGLE-PILL ANTIHYPERTENSIVE COMBINATION THERAPY
Authors: Dogas Hana , Radic Josipa , Vuckovic Marijana , Gelemanovic Andrea , Kolak Ela , Nenadic Dora Bucan , Radic Mislav 
Published: June 2023

Objective:
The need for polytherapy is common among people affected by arterial hypertension (AH). A single-pill combination is a response to decreased medication adherence, especially in elderly people often suffering from more than one disease, which tends to improve blood pressure control and cardiovascular outcomes. The aim of our study was to determine the frequency of use of a single-pill antihypertensive combination (SPC) therapy and possible differences in presence of comorbidities.

Design and method:
324 hypertensive participants on pharmacological treatment were included in this research, of which 51.2% were men, and with an overall median age of 64 years (IQR = 17). For each participant undergoing 24-hour ambulatory blood pressure measurement, data about pharmacological therapy, weight, height and comorbidities such as chronic kidney disease (CKD) and diabetes mellitus (DM) were obtained from their most recent medical records combined with self reports. Body mass index (BMI) was calculated.

Results:
148 (45.7%) participants were prescribed a SPC. Participants taking a SPC had lower presence of CKD (23.7% with CKD vs. 76.3% without CKD, p<0.001). No significant difference was found in the presence of DM (p = 0.496). Another interesting finding was more frequent use of SPC therapy among patients with higher BMI (p = 0.029).

Conclusions:
The results show that less than half of the participants in our study were prescribed an SPC. From this we can conclude that more attention should be paid to educating people about the options for antihypertensive treatment and simplifying therapy regimen. Another point we should highlight is the limited availability of SPCs in the treatment of hypertension in patients suffering from CKD.
USE OF COMBINATION TREATMENT IN HYPERTENSION MANAGEMENT AND ITS ASSOCIATION WITH HYPERTENSION CONTROL
Authors: Croce Alessandro , Bilo Grzegorz , Pengo Martino , Gorini Francesca , Amato Franca , Sucapuca Richard , Rosa Debora , Parati Gianfranco 
Published: June 2023

Objective:
Achievement of blood pressure (BP) targets in hypertension is crucial for cardiovascular prevention and, in most cases, requires combined pharmacological treatment. Current ESC/ESH Guidelines for hypertension management recommend initiating treatment with combination therapy in most hypertensives, except low-risk individuals with mildly elevated BP. Our aim was to assess how this recommendation is applied in practice and whether it is associated with differences in hypertension control.

Design and method:
In the setting of an ongoing cardiovascular prevention trial (CV-PREVITAL) we prospectively recruited 278 hypertensive patients with no history of cardiovascular disease, among individuals who responded to the advertisement campaign in outpatient facilities of Istituto Auxologico Italiano. Physical examination, standard routine blood tests, office blood pressure recording and standard 24h ABPM has been performed at baseline. We analyzed the office and ambulatory BP control in relationship to the number of antihypertensive drugs and cardiovascular risk assessed by SCORE for low risk countries.

Results:
Median age of our sample was 61 years, with balanced gender distribution. Ninety-nine (36%) participants were not receiving any pharmacological treatment, 106 (41%) were on monotherapy and 73 (23%) on combined treatment. Comparison of principal characteristics among the three groups is shown in Table 1.
Among study participants 44 (16%) had low to moderate CV risk and 227 (84%) had high or very high estimated risk. The percentage of participants receiving combined treatment in these groups was 4.1% and 22.5%, respectively, and the percentage of patients with well controlled office/ambulatory BP was 50%/41% in low to moderate risk and 35%/65% in high to very high risk participants, respectively.

Conclusions:
In this sample of patients with known hypertension, a considerable proportion received substandard treatment (no treatment or monotherapy), even among those at high risk. This was associated with worse BP control in these individuals. Implementation of current hypertension guidelines in practice remains largely suboptimal.
ASSESSMENT OF TRADITIONAL HERBAL REMEDIES USE AND MEDICAL TREATMENT AMONG HYPERTENSIVE PATIENTS ATTENDING PRIMARY HEALTH CARE CENTERS IN KHARTOUM STATE 2022-2023
Authors: Alhaj Waleed Mohammed , Mohammed Hazim Hassan , Jaber Mohammed Hammad , Abdelgadir Hiba S 
Published: June 2023

Objective:
Hypertension is the leading risk factor for cardiovascular disease mortality worldwide. It affects approximately 74.7 million people in Sub-Saharan Africa, and this figure is expected to increase to 125.5 million by 2025. Although antihypertensive drugs have been used to decrease blood pressure; traditional herbal remedies have been utilized within local or regional practices, in up to 80% of African populations.
The current study was carried out to assess adherence to medications and perception of Hypertensive patients regarding use of herbal treatment.

Design and method:
This was a descriptive cross-sectional facility centres-based study at 3 PHC centers. A total of 100 hypertensive patients were enrolled using multi-stage sampling. The data was collected by modified open and closed ended interview questionaries. Modified Morisky score system was used to assess adherence to medical treatment

Results:
The study population was 100 participants of which (57%) were females. Most of the participants (77%) were in the age group of 51 and above, (49%) had secondary and higher levels of education, (66%) were using Single type of drug and (77%) were in regular clinical checkup, (90%) were taking their medications as prescribed by their physicians, (58%) were diagnosed before ten years or more, (43%) had Diabetes as co-morbid. Fifty one percent of the participants had low adherence to medication. Forty nine percent of participants used herbal remedies with 67.3% of them had low adherence to their medications; Hibiscus was the most commonly used herb (31%). There was significant association between lack of adherence and the medication unavailability (p = .009).there was significant association between lack of adherence and taking more than one medication (p = 0.001);and between lack of adherence and lack of confidence in medical treatment (p = 0.012).

Conclusions:
A significant proportion of hypertensive patients are using herbal remedies which is negatively affects their adherence to the prescribed medications
In Utero Enzyme-Replacement Therapy for Infantile-Onset Pompe's Disease
Authors: Cohen Jennifer L. , Chakraborty Pranesh , Fung-Kee-Fung Karen , Schwab Marisa E. , Bali Deeksha , Young Sarah P. , Gelb Michael H. , Khaledi Hamid , DiBattista Alicia , Smallshaw Stacey , Moretti Felipe , Wong Derek , Lacroix Catherine , El Demellawy Dina , Strickland Kyle C. , Lougheed Jane , Moon-Grady Anita , Lianoglou Billie R. , Harmatz Paul , Kishnani Priya S. , MacKenzie Tippi C. 
Published: June 2023

(Abstracted from N Engl J Med 2022;387:2150–2158
Some diseases, such as early-onset lysosomal storage diseases, are so destructive that organ damage begins before birth, in utero. For some of these conditions, therapies have been developed to reduce damage and increase the likelihood of a higher quality of life in affected patients.
Maternal and Neonatal Outcomes of Trial of Labor Compared With Elective Cesarean Delivery According to Predicted Likelihood of Vaginal Delivery
Authors: Downs Sarah , Mokhtari Neggin , Gold Stacey , Ghofranian Atoosa , Kawakita Tetsuya 
Published: June 2023

(Abstracted from J Matern Fetal Neonatal Med 2022;35(26):10487–10493
In 2007, the Maternal-Fetal Medicine Unit (MFMU) Network developed the vaginal birth after cesarean (VBAC) calculator to help optimize the likelihood of a successful vaginal delivery. One study found that the risk of maternal and neonatal morbidity is no greater than that of elective repeat cesarean delivery (CD)—specifically when the likelihood of successful VBAC is >70%.
Buprenorphine Versus Methadone for Opioid Use Disorder in Pregnancy
Authors: Suarez Elizabeth A. , Huybrechts Krista F. , Straub Loreen , Hernández-Díaz Sonia , Jones Hendrée E. , Connery Hilary S. , Davis Jonathan M. , Gray Kathryn J. , Lester Barry , Terplan Mishka , Mogun Helen , Bateman Brian T. 
Published: June 2023

(Abstracted from N Engl J Med 2022;387:2033–2044
Opioid use disorder (OUD) affects approximately 8.2 per 1000 deliveries in the United States. Among those insured by Medicaid, the disorder affects 14.6 per 1000 deliveries.
Efficacy and Safety of Mirvetuximab Soravtansine in Patients With Platinum-Resistant Ovarian Cancer With High Folate Receptor Alpha Expression: Results From the SORAYA Study
Authors: Matulonis Ursula A. , Lorusso Domenica , Oaknin Ana , Pignata Sandro , Dean Andrew , Denys Hannelore , Colombo Nicoletta , Van Gorp Toon , Konner Jason A. , Marin Margarita Romeo , Harter Philipp , Murphy Conleth G. , Wang Jiuzhou , Noble Elizabeth , Esteves Brooke , Method Michael , Coleman Robert L. 
Published: June 2023

(Abstracted from J Clin Oncol 2023;41(13):2436–2445
Approximately 80% of patients with ovarian cancer experience recurrence after platinum-based chemotherapy, and unfortunately nearly all will eventually develop platinum-resistant ovarian cancer (PROC). Treatment in this setting consists of nonplatinum chemotherapy with or without bevacizumab; however, each successive line of therapy in PROC is associated with progressively lower response rates.
Transcription of MERVL Retrotransposons Is Required for Preimplantation Embryo Development
Authors: Sakashita Akihiko , Kitano Tomohiro , Ishizu Hirotsugu , Guo Youjia , Masuda Harumi , Ariura Masaru , Murano Kensaku , Siomi Haruhiko 
Published: June 2023

(Abstracted from Nat Genet 2023;55(3):484–495
Zygotic genome activation (ZGA) is a critical developmental step that occurs after fertilization of the embryo and promotes totipotency, allowing different cell fates to emerge in the developing embryo. In mice, the expression of murine endogenous retrovirus with leucine transfer RNA primer binding site (MERVL), a known marker of totipotency, becomes specifically activated at the 2-cell stage concomitant with ZGA.
Decreasing Decision-to-Incision Times for Unscheduled, Urgent Cesarean Deliveries
Authors: Tibavinsky Bernal Lina , Yarrington Christina D. , Xuan Ziming , Zani Lisa , Friedman Scott , Schultz Michele , Chandra Phanirekha , Iverson Ronald E. 
Published: June 2023

OBJECTIVE:
To standardize the preprocedure process for urgent, unscheduled cesarean deliveries to decrease the time from decision to skin incision to improve maternal and fetal outcomes.

METHODS:
In our quality-improvement project, we selected indications that require urgent cesarean deliveries, created a standard algorithm, then implemented a multidisciplinary process intended to reduce decision-to-incision time. This initiative was conducted from May 2019 to May 2021, with a preimplementation period from May 2019 to November 2019 (n=199), implementation period from December 2019 to September 2020 (n=283), and postimplementation period from October 2020 to May 2021 (n=160). An interrupted time series calculation was performed, with stratification by patient race and ethnicity. The primary process measure was mean decision-to-incision time. The secondary outcomes were neonatal status as measured by 5-minute Apgar score and quantitative blood loss during the cesarean delivery.

RESULTS:
We analyzed 642 urgent cesarean deliveries; 199 were preimplementation of the standard algorithm, and 160 were postimplementation. The mean decision-to-incision time improved from 88 minutes (95% CI 75–101 min) to 50 minutes (95% CI 47–53 min) from the preimplementation period to the postimplementation period. When stratified by race and ethnicity, the mean decision-to-incision time among Black non-Hispanic patients improved from 98 minutes (95% CI 73–123 min) to 50 minutes (95% CI 45–55 min) (t=3.27, P<.01); it improved from 84 minutes (95% CI 66–103 min) to 49 minutes (95% CI 44–55 min) among Hispanic patients (t=3.51, P<.001). There was no significant improvement in decision-to-incision time among patients in other racial and ethnic groups. When the cesarean delivery was performed for fetal indications, Apgar scores were significantly higher in the postimplementation period compared with the preimplementation period (8.5 vs 8.8 beta=0.29, P<.01).

CONCLUSION:
Development and implementation of a standard algorithm to expedite decision-to-incision time for unscheduled, urgent cesarean deliveries led to a significant decrease in decision-to-incision time.
Effects of Same-Day Discharge on 30-Day Readmission Rates in Women Aged 65 Years and Older Undergoing Minimally Invasive Pelvic Organ Prolapse Surgery
Authors: Berger Alexander A. , Bretschneider C. Emi , Gregory W. Thomas , Sung Vivian 
Published: June 2023

OBJECTIVE:
To compare the effects of same-day discharge on 30-day readmission after minimally invasive pelvic organ prolapse (POP) surgery in older patients.

METHODS:
This retrospective cohort study examined all minimally invasive POP surgeries performed and included in the national Centers for Medicare & Medicaid Services 5% Limited Data Set (2011–2018). Our primary outcome was 30-day hospital readmission, and our secondary outcome was 30-day emergency department (ED) visits.

RESULTS:
Of the 7,278 patients undergoing surgery, patients who had same-day discharge were older (73.5 years vs 73.1 years, P=.04) and less likely to undergo concomitant hysterectomy (9.5% vs 34.9%, P<.01) or midurethral sling (36.8% vs 40.1%, P=.02). Same-day discharge increased over the study period from 15.7% in 2011 to 25.5% in 2018 (P<.01). On propensity score–matching multiple logistic regression, the adjusted difference was statistically significant, with same-day discharge increasing the odds of 30-day readmission compared with next-day discharge (adjusted odds ratio [OR] 1.57, 95% CI 1.19–2.08). There was no difference (OR 0.81, 95% CI 0.63–1.05) for 30-day ED visits on propensity score–matching multiple logistic regression.

CONCLUSION:
After minimally invasive POP surgery, older women have low rates of readmission and ED visits within 30 days. After propensity score matching and adjustment for perioperative factors, there may be increased odds in readmission and no difference in ED visits risk in those who had same-day discharge. When considering patient factors, same-day discharge after minimally invasive POP surgery may be effective for older patients.
Hemorrhoidal Artery Ligation for the Treatment of Grade II-III Hemorrhoids: Is it Worth the Use of Doppler Guide in Long-Term Follow-Up?: A Single-Center Cohort Study
Authors: Bonomo Luca Domenico , Falletto Ezio , Cuccomarino Salvatore , Nicotera Antonella , Jannaci Alberto 
Published: June 2023

Background:
Hemorrhoidal artery ligation (HAL) may reduce postoperative pain and complications and shorten patients’ recovery when compared to standard hemorrhoidectomy. It is unclear if the Doppler guide (DG) is useful in reducing recurrence risk.

Objective:
To compare two groups of patients (treated with DG-HAL or HAL) in terms of recurrence risk and patients’ satisfaction grade.

Methods:
Between January 1, 2014 and January 31, 2021, 122 patients affected by grade II-III hemorrhoidal prolapse underwent DG-HAL or HAL at Chivasso Hospital, Italy. Mucopexy was routinely performed. After discharge, patients were subjected to 1-week, 1-, 3-, 6-, and 12-month clinical assessment. Thereafter, they were interviewed by telephone annually.

Results:
Seventy-six (62.3%) DG-HAL and 46 (37.7%) HAL procedures were performed. Median surgical time was 30 (15–45) minutes for DG-HAL versus 25 (15–40) minutes for HAL (P = 0.005). No intraoperative complications occurred. Postoperative bleeding needing surgery occurred in 2 (1.6%) patients in the DG-HAL group. During a median follow-up of 46 months (6–86), we registered 18 (23.7%) recurrences in the DG-HAL group and 13 (28.3%) in the HAL one (P = 0.574). No cases of incontinence or anal stenosis occurred. No significant difference was observed between the two groups in terms of patients’ satisfaction. At multivariate analysis, age ≥ 65 years resulted a protective factor for recurrence (odds ratio 0.31; 95% confidence interval 0.09–0.98; P = 0.047).

Conclusions:
In our study, the use of DG did not reduce recurrence risk. Operative time was significantly increased in the DG-HAL group.