bluuebunny/crossref_metadata_2025_split huggingface dataset:
Molecular characterization of Porokeratosis in Tunisian patients with intraindividual and intrafamilial clinical heterogeneity
Authors: Mabrouk Haifa El , Li Dong-lin , Mokni Sana , Chouk Hamza , Ghariani Nadia , Bousoffara Lobna , Saad Ali , Denguiezli Mohamed , Has Cristina , H’mida Dorra 
Published: April 2023

Abstract
Background
Porokeratosis (PK) is a group of rare acquired or inherited clonal keratinization disorders characterized by annular or linear hyperkeratotic plaques with central atrophy and raised borders. Cornoid lamella is the common histological feature between PK forms. Genes of the mevalonate pathway are implicated in the pathogenesis of this pathology. To date, the exact underlying molecular mechanisms remain misunderstood.
Results
In this study, we investigated two unrelated Tunisian families with heterogeneous PK for whom we reported a clinical heterogeneity with a simultaneous presence of three clinical forms of PK in two individuals. We identified two PMVK variants, nonsense and synonymous, in affected individuals and unaffected relatives. We suggest that the PK profiles of our Tunisian patients result from the germline nonsense mutation c.412A > T (p.R138*) responsible for the haploinsufficiency of the PMVK protein via the degradation of the mutant mRNA by the nonsense-mediated mRNA decay (NMD) mechanism and d a second hit postzygotic mutation in skin lesions. We suggest that the synonymous variant c.147A > G (p.E49=) could be a genetic predisposition factor increasing the susceptibility to the second hit mutation in the PMVK gene or another gene.
Conclusion
We report the first molecular characterization of PK within the Tunisian and North African populations. Our findings support the common molecular background of different clinical subtypes of PK and the fact that they can be considered a single disorder.
An EOQ model for a two warehouse system with price and time dependent demand and instantaneous deterioration during COVID-19 pandemic
Authors: Das Dolagobinda , Samanta Gauranga Charan 
Published: April 2023

Abstract
This paper develops an inventory model considering a demand disruption and a linear price and time dependent demand. In this model, we analyze two possibilities and apply the FIFO dispatch policy. In the first scenario, the inventories of the owned warehouse (OW) get vacant after the lock-down relieves owing to a shorter lock-down duration, but in the second scenario, the inventories of the OW get vacant during the lock-down due to a longer lock-down duration. A two parametric Weibull distribution has been considered to mirror the real problems caused by deterioration. The study aims to minimize the total cost of a two-warehouse system during the lock-down time. Furthermore, sensitivity analysis was used to investigate the models' behavior. Taking into consideration actual conditions, this model might be useful in an emergency situation like the COVID-19 epidemic.
Causes of Excess Capacity in the Manufacturing Sector
Authors: Pal Samidh 
Published: April 2023

Abstract
This study delves into the origins of excess capacity by examining the reactions of capital, labor, and capital intensity. To achieve this, we have employed a novel three-layered production function model, estimating the elasticity of substitution between capital and labor as a nested layer, alongside capital intensity, for all industry groups. We have then selectively analyzed a few industry groups for comparative purposes, taking into account the current government policies and manufacturing plant realities. Ultimately, we recommend that policymakers address the issue of excess capacity by stimulating the expansion of manufacturing plants with cutting-edge machinery. Our findings and recommendations are intended to appeal to academics and policymakers alike.
JEL Code: L6, L5.
Liver-On-A-Chip Model: an Alternative to Animal Models-Development Challenges and Future Perspectives
Authors: Gulla Aiste , Leber Bettina , Butkutė Agnė , Stiegler Phillipp , Jurkšas Tomas , Baravykas Tomas , Kvietkauskas Mindaugas , Marcinkevičiūtė Kristina , Schemmer Peter , Strupas Kęstutis 
Published: April 2023

Abstract
Purpose: To create a fast, affordable, reproducible a liver-on-a chip platform as an alternative to animal models of liver diseases.
Methods: The platform was fabricated out of fused silica by using femtosecond laser microprocessing. A channel with integrated filters of micropillars was produced by Selective Laser Etching (SLE) technique. Nano gratings were inscribed inside the glass by using focused femtosecond laser radiation. Subsequently, liver cells were etched in 35% Potassium Hydroxide (KOH) at 90 ° C or Hydrofluoric acid. The contact between both plates was achieved by intense light radiation with an integrated filter. There were 700 fs duration pulses used for SLE and 200 fs for laser welding. The light was focused with a 20 x 0.45 NA objective for SLE and a 0.5 NA aspherical lens for laser welding. The human liver HCC cell line HepG2(GS) was employed for biocompatibility testing.
Results: The platform consists of one channel divided into three sub channels by micropillars: the central channel for cells and two side channels for cell medium. All channels have inlet and outlet reservoirs with the depth up to 200 μm, and width of central and side channels up to 200 and 400 μm, respectively. Additionally, the final size of micropillars was 55 x 36 μm with a gap of 14 μm in between.
Conclusion: Based on our previously published work, this study provides a step-by-step design and validates the concept of testing human liver cancer cells. In addition, it provides developmental advancements and drawbacks of liver-on-a-chip designs.
Systematic review of empiric studies on lockdowns, workplace closures, and other non- pharmaceutical interventions in non-healthcare workplaces during the initial year of the COVID-19 Pandemic: Benefits and selected unintended consequences
Authors: Ahmed Faruque , Shafer Livvy , Malla Pallavi , Hopkins Roderick , Moreland Sarah , Zviedrite Nicole , Uzicanin Amra 
Published: April 2023

Abstract
Background
We conducted a systematic review aimed to evaluate the effects of nonpharmaceutical interventions within non-healthcare workplaces and community-level workplace closures and lockdowns on COVID-19 outcomes in workers or the general community and on selected mental health and labor market outcomes.
Methods
The inclusion criteria included systematic reviews, randomized controlled trials, and non-randomized studies. The exclusion criteria included qualitative, and modeling studies. Electronic searches were conducted using MEDLINE, Embase, and other databases from January 1, 2020, through May 11, 2021. Risk of bias was assessed using the Risk of Bias in Non-Randomized Studies of Interventions (ROBINS-I) tool. A qualitative synthesis was performed.
Results
A total of 60 studies met the inclusion criteria. There were 40 studies on COVID-19 outcomes, 15 on anxiety and depression symptoms, and five on unemployment and labor force participation. There was a paucity of studies on physical distancing, physical barriers, and symptom and temperature screening within workplaces. Workplace closures significantly reduced COVID-19 incidence or growth rate (five of seven studies) and reproduction number (three of four studies) in the general community. Lockdown significantly reduced COVID-19 incidence and case growth rate (22 of 23 studies), reproduction number (10 of 11 studies), and COVID-19 mortality and death growth rate (seven of seven studies) in the general community. Lockdown significantly increased depression symptoms (10 of 15 studies), but the effect on anxiety symptoms was inconsistent. Lockdown increased unemployment (five studies) and decreased labor force participation (three studies). The risk of bias for most of the studies on COVID-19 or labor market outcomes was moderate or serious. The risk of bias for the studies on anxiety or depression symptoms was serious or critical.
Conclusions
Empiric studies that assessed the effect of workplace closures and lockdowns suggest that these measures helped reduce the impact of COVID-19, albeit with notable secondary (unwanted) effects. There is a pronounced paucity of studies on the effect of interventions, including symptom and temperature screening as well as less disruptive nonpharmaceutical interventions such as physical distancing measures within still-open workplaces. Addressing the gaps in the evidence base would be important for informing future pandemic preparedness.
Systematic review registration number:
PROSPERO registration # CRD42020182660.
Phytochemicals and Antioxidant Activities of Red Oak, Red Coral and Butterhead
Authors: Nadechanok Jiangseubchatveera  , Charinrat Saechan  , Arpa Petchsomrit  , Tawikan Treeyaprasert  , Nattawut Leelakanok  , Chadaporn Prompanya  
Published: April 2023

Lactuca sativa L. is an economically important vegetable that contains numerous phytochemicals. This study aimed to determine the phytochemicals in three lettuce cultivars (red oak, red coral, and butterhead) and assess their total phenolics, total flavonoids, and antioxidant activities. The dried leaves of each lettuce cultivar were macerated with hexane, ethyl acetate (EtOAc), and 95% ethanol (EtOH). Total phenolics, total flavonoids and antioxidant activities from the three solvent extracts were measured. The phytochemical screening showed that the leaves from the three lettuce cultivars contained flavonoids, hydrolyzable tannins, coumarins, steroids, and phenolic compounds. While the EtOAc fraction of the red coral lettuce showed the highest total phenolic content (9.747 ± 0.021 mg gallic acid equivalent/g) and the hexane fraction of the butterhead lettuce contained the highest flavonoids (7.065 ± 0.005 mg quercetin equivalent/g). In the DPPH (2,2-diphenyl-1-picryl-hydrazyl-hydrate) assay, the EtOAc fraction of the red coral lettuce had the highest antioxidant capacity with an IC50 of 0.277 ± 0.006 mg/mL, whereas, in the ABTS (2,2’-azino-bis(3- ethylbenzothiazoline-6-sulfonic acid)) assay, the 95% EtOH of the red coral lettuce had the highest antioxidant capacity with an IC50 of 0.300 ± 0.002 mg/mL. All three lettuce cultivars contained high levels of phenolic content and flavonoids, which are the source of antioxidant activities. These lettuce cultivars, especially the red coral lettuce, are a potential source of natural antioxidants. Further research on the application of natural antioxidants is required to investigate the therapeutic or the neutraceutical implication of the lettuce cultivars.
Direct Determination of Glyphosate, Glufosinate, and AMPA in milk by Liquid chromatography/tandem mass spectrometry
Authors: Chamkasem Narong , Morris Cynthia , Harmon Tiffany 
Published: April 2023

A simple high-throughput liquid chromatography/tandem mass spectrometry (LC-MS/MS) method was developed for the determination of glyphosate, aminomethylphosphonic acid (AMPA) and glufosinate in milk using a reversed-phase liquid chromatography column with weak anion/cation exchange stationary phase. One milliliter of milk was shaken with three milliliters of water containing Na2EDTA and acetic acid for 10 minutes, to precipitate the protein content in the sample. After centrifugation, the supernatant was passed through an Oasis HLB SPE to retain suspended particulates and phospholipids. The sample was directly injected and analyzed in 6 min, with no sample concentration or derivatization steps. Two multiple reaction monitoring (MRM) channels were monitored in the method for each target compound to achieve true positive identification. Three internal standards corresponding to each analyte were used to counter matrix suppression effects. The linearity of the detector response was demonstrated in the range of 4 to 1000 ng/mL for each analyte, with a minimum coefficient of determination (R2) value of more than 0.995. Through the use of this internal standard calibration method, the average recovery for all analytes at 0.025, 0.1, 0.5, and 2 µg/g (n = 7) are between 84-111% with a relative standard deviation of less than 8%.https://doi.org/10.21423/jrs-v03n02p020 (DOI assigned 8/7/2019)
Local and global sensitivity analysis and its contributing factors in reference crop evapotranspiration
Authors: Yong Stephen Luo Sheng , Ng Jing Lin , Huang Yuk Feng , Ang Chun Kit , Mirzaei Majid , Ahmed Ali Najah 
Published: April 2023

Abstract
Sensitivity analysis (SA) intends to identify the key meteorological variables that affect the performance of reference crop evapotranspiration (ET0) models. It is of importance in assessing the variability of meteorological variables and ET0, especially in the face of increasing climate uncertainties. However, the surging of inconsistencies resulting from global changes in meteorological conditions due to climate change have impacted the ET0 model estimation in different regions, with detrimental effects on water resources and crop production. Therefore, efficient SA is necessary to evaluate the impact of changes in meteorological variables that influence ET0 model estimation. This mini review analyses the various SA methods applied in the field of ET0, based on a comprehensive and comparative analysis of existing SA methods from all around the world. The study discusses the advantages and disadvantages of each SA method, as well as the factors affecting the SA of ET0. The study also provides future prospects that may contribute to more solid and powerful analysis for ET0 model estimations and conclusions.
Spatial mapping of water spring potential using four data mining models
Authors: Al-Shabeeb Abdel Rahman , Hamdan Ibraheem , Al-Fugara A'kif , Al-Adamat Rida , Alrawashdeh Mohammed 
Published: April 2023

AbstractPopulation growth and overexploitation of water resources pose ongoing pressure on groundwater resources. This study compares the capability of four data mining methods, namely, boosted regression tree (BRT), random forest (RF), multivariate adaptive regression spline (MARS), and support vector machine (SVM), for water spring potential mapping (WSPM) in Al Kark Governorate, east of the Dead Sea, Jordan. Overall, 200 spring locations and 13 predictor variables were considered for model building and validation. The four models were calibrated and trained on 70% of the spring locations (i.e., 140 locations) and their predictive accuracy was evaluated on the remaining 30% of the locations (i.e., 60 locations). The area under the receiver operating characteristic curve (AUROCC) was employed as the performance measure for the evaluation of the accuracy of the constructed models. Results of model accuracy assessment based on the AUROCC revealed that the performance of the RF model (AUROCC = 0.748) was better than that of any other model (AUROCC SVM = 0.732, AUROCC MARS = 0.727, and AUROCC BRT = 0.689).
Síndrome de Evans na evolução de doença autoimune:
Authors: Henrique nunes Samon , Dos Santos-Silva Marco Aurélio , André Vaz Ricardo 
Published: April 2023

Lúpus Eritematoso Sistêmico (LES) é uma doença inflamatória crônica, sistêmica, de causa desconhecida e natureza autoimune. Decorre do desequilíbrio da atividade imunológica inata e adquirida por fatores genéticos, ambientais e hormonais. A Síndrome do Anticorpo Antifosfolipídeo (SAF) é a associação de trombose e / ou morbidade gestacional com anticorpos antifosfolípides (anticoagulante lúpico, anticorpos anticardiolipina e / ou anticorpos anti-β2 -glicoproteína-I). Síndrome de Evans é caracterizada pela destruição autoimune das hemácias e plaquetas levando ao aparecimento concomitante e sequencial de Púrpura Trombocitopênica Idiopática (PTI) e Anemia Hemolítica Autoimune (AHAI). O presente objetiva identificar quais indícios apontam para LES ou SAF como causa da Síndrome de Evans em uma paciente assistida no Hospital Universitário de Vassouras (HUV). O estudo justifica-se pela necessidade de atualização desse tema de importante relevância médica, visto os poucos relatos na literatura a esse respeito. Paciente, 31 anos, sexo feminino, deu entrada no HUV com quadro de TVP/TEP. Evoluiu com AHAI e PTI (Síndrome de Evans), o que levou à investigação de estados pró-trombóticos. Considerando os critérios para LES e SAF, verificou-se que a paciente preenchia critérios diagnósticos para SAF (TVP/TEP + anticoagulante lúpico positivo), porém não preenchia critérios para LES, pois apresentava critérios laboratoriais (anemia hemolítica, trombocitopenia e anticorpo antifosfolipídeo positivo), porém não apresentava nenhum critério clínico. Conclui-se que a paciente apresentou SAF primária, e que esta foi a provável causa da Síndrome de Evans, já que não existem marcadores específicos para LES nesta situação.
Effect of Early Balloon Inflation of Balloon Guide Catheter in Mechanical
Thrombectomy for Large Vessel Occlusion
Authors: Yi Ho Jun , Kang Beom Mo , Shin Dong-Seong , Kim Bum-Tae 
Published: April 2023

Objective:
A balloon guide catheter (BGC) is widely used in mechanical thrombectomy
(MT). However, the balloon inflation timing of BGC has not been clearly established. We evaluated
whether balloon inflation timing of BGC affects the results of MT.

Methods:
Patients who underwent MT with BGC for anterior circulation occlusion were enrolled.
Patients were dichotomized into early and late balloon inflation groups, according to the timing of
BGC inflation. Angiographic and clinical outcomes were compared between the two groups. Multivariable
analyses were performed to evaluate the predictive factors for first-pass reperfusion
(FPR) and successful reperfusion (SR).

Results:
Of 436 patients, the early balloon inflation group showed a shorter procedure time (21
min (11-37) vs. 29 min (14-46), p = 0.014), a higher rate of SR with aspiration only (64.0% vs.
55.4%, p = 0.016), a lower aspiration catheter delivery failure rate (11.1% vs. 19.4%, p = 0.005),
less frequent technique conversion (36.0% vs. 44.5%, p = 0.009), higher rate of FPR (58.2% vs.
50.2%, p = 0.011), and a lower rate of distal embolization (7.9% vs. 11.7%, P = 0.006), compared
to the late balloon inflation group. In multivariate analysis, early balloon inflation was an independent
predictor for FPR (odds ratio, OR 1.53, 95% confidence interval, CI 1.37–2.57; p = 0.011)
and SR (OR 1.26, 95% CI 1.18-1.64; p = 0.018).

Conclusion:
Early balloon inflation of BGC enables an effective procedure than late balloon inflation.
Early balloon inflation was associated with higher rates of FPR and SR.
A Review on Inhibitory Action of Tyrosine Kinase Inhibitors (TKI) by
Curbing the ATP-Tyrosine Kinase Interactions
Authors: Kumar Vanktesh , Kaur Navjot 
Published: April 2023

Abstract:
According to the latest data, the cancer prevalence fraction has surged to the highest number. This is why cancer has become a prominent disease that must be seen as a serious issue. Inhibitory action and ideas become prominent and necessary because of the rising death incidence daily. The simplifying idea of inhibition of cancer is targeting the complex that forms between the tyrosine kinase and ATP, which ultimately provides a clear way. Tyrosine kinase is a proteinaceous enzyme responsible for various cellular events like cell development, growth, and division. But these functions are performed by the activated tyrosine kinase, and the activation occurs by phosphorylation using ATP. The transfer of the phosphate group from ATP to tyrosine is known as phosphorylation. The basic idea is to enhance the competitive inhibition of the ATP-Tyrosine complex is a promising target for treating cancer. Various molecules have a substantial effect on the above-said target. This review summarizes molecules currently in any drug development or clinical trial with the same effect. This review covers most inhibitory molecules from different categories, which either directly or indirectly inhibit the Tyrosin kinase-ATP complex by incorporating.
KLASIFIKASI KODE MUTU KAYU PROVINSI SULAWESI SELATAN
Authors: Khairil Khairil 
Published: April 2023

ABSTRACT Since wood regulations were revised in 2002, the strength classes of wood are no longer known as class I, II, III, IV and V but known as quality code. The highest quality code is E26 and the smallest is E10. With these changes, it is very possible to confuse the community, especially in the province of South Sulawesi in choosing the type of wood that will be used for construction. This study aims to classify the wood quality code in the province of South Sulawesi based on PKKI NI-5 2002.The study begins by choosing the woods in South Sulawesi to be testing the water content and density of that woods. The result of the tested are used to calculate flexural modulus of elasticity as a basis in determining the wood quality code. The result showed that from 18 kinds of wood studied, twelve kinds of wood have a quality code from E9 to E15 and another six do not have quality code. The six types of wood do not have quality code because the flexural modulus of elasticity of that wood less than 9000 MPa where that value is not classified in PKKI NI-5 2002.Keywords: density, quality code of wood, wood in South Sulawesi, water content, ABSTRAK Sejak peraturan kayu direvisi pada tahun 2002,penggolongan kelas kuat kayu tidak lagi dikenal sebagai kelas kuat I, II, III, IV dan V namun dikenal dengan istilah kode mutu. Kode mutu terbesar adalah E26 dan yang terkecil E10. Dengan perubahan tersebut, makasangat mungkin dapat membingungkan masyarakat khususnya di provinsi sulawesi selatan dalam memilih jenis kayu yang akan digunakan untuk keperluan konstruksi.Penelitian ini bertujuanuntuk mengklasifikasikan kode mutu kayu yang beredar di provinsi Sulawesi Selatan berdasarkan PKKI NI-5 2002. Penelitian diawali dengan memilih jenis kayu yang beredar di provinsi Sulawesi Selatan dan selanjutnya dilakukan pengujian kadar air dan kerapatan kayu tersebut untuk digunakan dalam menentukan nilai modulus elastisitas lentur. Dengan nilai modulus elastisitas lentur yang tersebut, maka kode mutu kayu dapat ditentukan. Hasil penelitian memperlihatkan bahwa dari 18 belas jenis kayu yang diuji, dua belas jenis kayu memiliki kode mutu yaitu E9sampai E15 dan enam jenis kayu yang lain tidak memiliki kode mutu kayu. Keenam jenis kayu tersebut tidak memiliki kode mutu karena nilai modulus elastisas lenturnya lebih kecil dari 9000 MPa dimana nilai modulus elastisitas lentur tersebut tidak di klasifikasikan dalam PKKI NI-5 2002.Kata kunci: kerapatan, kode mutu kayu, kayu provinsi Sulawesi Selatan, kadar air