bluuebunny/crossref_metadata_2025_split huggingface dataset:
Feasibility of extended ultrasound examination of the fetal brain between 24 and 37 weeks’ gestation in low-risk pregnancies
Authors: Viñals Fernando , Correa Flavia , Escribano David , Hormazábal Lorena , Diaz Linder , Galindo Alberto , Zambrano Belkys , Quiroz Gabriel , Saint-Jean Constanza 
Published: April 2023

Abstract

Objectives
To assess the feasibility of identifying fetal brain structures and anatomic landmarks included in the anterior complex (AC) and posterior complex (PC), as well as the proximal hemisphere (PH).

Methods
This was a prospective observational multicenter study of healthy pregnant women evaluated by ultrasound screening at 24 to 36 + 6 weeks’ gestation. Six physicians performed transabdominal ultrasound, to obtain the planes required to visualize the AC, PC, and PH. Blind analysis by an expert and non-expert operator in fetal neurosonography was used to assess the structures included in each plane view.

Results
In the population studied (n=366), structure detection rates for AC were over 95 %, with an agreement of 96 % when comparing expert and non-expert examiners. Visualization of the corpus callosum crossing the midline was detected in over 97 and 96 % of cases for the AC and PC, respectively, with an agreement of over 96 %. The PH plane, particularly through the posterior access via the mastoid fontanelle, enabled visualization of the proximal anatomical structures in almost 95 % of cases. Detection of the corpus callosum through the AC and PC, both proximal/distal germinal matrix (AC) and proximal Sylvian fissure through the anterior access (PH) in the 24–25 + 6, 26–31 + 6 and 32–36 + 6 weeks’ gestation groups were successful in over 96 % of cases with high level of agreement.

Conclusions
Inclusion of AC, PC, and PH later in pregnancy proves feasible with a high level of agreement between both expert and non-expert operators.
F-box and WD repeat domain containing 7 inhibits the activation of hepatic stellate cells by degrading delta-like ligand 1 to block Notch signaling pathway
Authors: Sun Yufeng , He Lili , Guo Peiran , Li Fenghua , Wang Bo , Zhang Yifan , An Kai , Peng Ming 
Published: April 2023

Abstract
Hepatic fibrosis (HF) is a precursor of liver cirrhosis, and activated hepatic stellate cells are an important driver of fibrosis. F-box and WD repeat domain containing 7 (FBXW7) expression level is down-regulated in HF, but the underlying mechanism is yet to be elucidated. The interaction between FBXW7 and delta-like ligand 1 (DLL1) was predicted. LX-2 cells were subjected to transfection of FBXW7/DLL1 silencing or overexpression plasmid. The expressions of FBXW7 and DLL1 in HF in vitro were measured by quantitative reverse transcription polymerase chain reaction and western blot. The LX-2 cell cycle, viability, proliferation, and ubiquitination were determined by flow cytometry, cell counting kit-8, colony formation, and ubiquitination assays, respectively. FBXW7 overexpression suppressed the cell viability and proliferation, facilitated cell cycle arrest, and down-regulated α-smooth muscle actin (α-SMA), Collagen I, and DLL1 protein levels, but FBXW7 silencing did the opposite. DLL1 was bound to and ubiquitin-dependently degraded by FBXW7 overexpression. DLL1 overexpression promoted the cell viability and proliferation, accelerated cell cycle, and up-regulated the levels of α-SMA, Collagen I, NOTCH2, NOTCH3, and HES1, but these trends were reversed by FBXW7 overexpression. To sum up, FBXW7 overexpression suppresses the progression of HF in vitro by ubiquitin-dependently degrading DLL1.
A Modal Contextualist Account of Essentialist Claims as a Response to Kit Fine
Authors: Nencha Cristina 
Published: April 2023

Abstract
Kit Fine advanced a remarkable objection to the Modal Account of Essentialism. Fine’s concern is commonly thought to have put the modal account in serious jeopardy. I believe that Fine’s objection is mainly based on two intuitions. As a reaction to Fine’s argument, while many scholars have abandoned the modal account, others have attempted to save it. The main strategy in the last direction consists in adding to the modal criterion a condition that is supposed to hold universally. For different reasons, this strategy ends up rejecting part of the first Fine’s intuition. I believe that a modal contextualist approach to essentialist claims, through the addition of a ‘particularist’ condition to the modal criterion, can provide an interesting alternative for those who wish to maintain a modal approach to essentialism. I will show that this approach, while rejecting the second Finean intuition, is able to account for his first intuition.
Use of a liquid chromatography-tandem mass spectrometry method to assess the concentration of epinephrine, norepinephrine, and phenylephrine stored in plastic syringes
Authors: Cohen Alejandro M. , Wiseman Luke , Al Faraj Ahmed , Andreou Pantelis , Hall Richard , Neira Victor M. 
Published: April 2023

Abstract

Objectives
There are concerns about the potency of epinephrine (EPI), norepinephrine (NE), and phenylephrine (PE) stored in syringes for later infusions in clinical care. The objective of our study was to optimize a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method to determine the concentrations EPI, NE, and PE dissolved in normal saline and stored in 50 mL 3-part Becton Dickinson syringes.

Methods
Medications were diluted in normal saline to 80 μg/mL for EPI and NE, and 100 μg/mL for PE. The solutions were stored in syringes for 0 (fresh), 3, and 7 days in a medical refrigerator. United States Pharmacopeia grade EPI, NE, and PE and their deuterium-labeled analogs were used as calibration standards. Stored samples and standards were diluted and analyzed by LC-MS/MS operated in selected reaction monitoring mode.

Results
The calculated limit of quantification for EPI, NE and PE were well below the concentrations used in clinical practice. The coefficient of variation remained below 12 % for all samples. The standard linear calibration regressions for EPI, NE, and PE had r

2
values of between 0.96 and 0.98 (p < 0.001). EPI and NE stored in the refrigerator remained within 10 % of the of their initial concentrations at all time points. The concentration of PE in syringe decreased by 19.85 % at 3 days, with no further decrease at 7 days, compared to fresh PE.

Conclusions
The sample preparation steps and optimized LC-MS/MS method allowed simple and reliable measurements of EPI, NE, and PE.
Effect of zero penetration angle chevrons in supersonic jet noise and screech tone mitigation
Authors: Periyasamy Kaleeswaran , Natarajan Kadiresh P. , Surendra Bogadi , Suresh Chandra Khandai 
Published: April 2023

Abstract
An experimental study is conducted to determine the effect of chevrons with zero penetration angles at the CD nozzle exit on an emitted noise field. The implication of passive control is to reduce the blockage of the nozzle exit area with minimal engine thrust penalty. The cold air jets issued at design Mach numbers 1.5 and 1.75 from the De Laval nozzles of the circular section were investigated. This passive control eliminates screech tones at the over and ideally expanded conditions at 60° and 90° in the azimuth plane. The acoustic data measurements have also been observed for the chosen jet Mach numbers. The schlieren images reveal the shock cell pattern to eliminate the effect of shock-associated noise levels at supersonic jets. The results show that 10 chevrons with no penetration act as an effective eliminator of screech tone and noise suppression average ∆OASPL value up to 3 dB at Mach number 1.75.
“Digital Taylorism” for some, “digital self-determination” for others? Inequality in job autonomy across different task domains
Authors: Kirchner Stefan , Meyer Sophie-Charlotte , Tisch Anita 
Published: April 2023

Abstract
In interdisciplinary debates, it is often assumed that changes in job autonomy in the course of digitalisation will be similar for all employees, even across task domains. Some authors postulate the emergence of a “digital Taylorism”, while others suggest that the digital transformation enables more “digital self-determination”. Based on a large-scale survey of employees in Germany, this article quantitatively examines both assumptions, with a particular focus on possible differences across job tasks. The results point to a systematic inequality between the task domains considered: Knowledge-related tasks seem to be associated with increased “digital self-determination”, while the results for manufacturing and service tasks tend towards a pattern of “digital Taylorism”. Overall, the debate needs to go beyond discussing possible future scenarios and address the complex links between job quality, digital technologies and tasks that are already changing the world of work today.
Frühaufklärung produktionstechnischer Defizite
Authors: Dobler Richard , Reinhart Gunther 
Published: April 2023

AbstractIndustriebetriebe stehen regelmäßig neuen Herausforderungen gegenüber, die es zu überwinden gilt. Viele dieser Herausforderungen finden ihren Ursprung in Diskontinuitäten. Um diese zu beherrschen, ist ein passendes Frühaufklärungssystem von Nöten. Trotz der Vielzahl an bestehenden Ansätzen wurde bisher kein Ansatz erforscht, der explizit produktionsrelevante Diskontinuitäten und deren Auswirkungen behandelt. Deshalb wird in diesem Beitrag eine Methodik zu diesem Zweck präsentiert.
Befähigung von KMU zur Nutzung von Machine-Learning-Potenzialen
Authors: Savadogo Manuel , Stonis Malte 
Published: April 2023

Abstract
Die Nutzung von Machine Learning hat sich bereits in vielen Bereichen des alltäglichen Lebens etabliert und findet zunehmend Anwendung. Auch im Bereich der Produktion und Logistik gewinnt Machine Learning immer mehr an Bedeutung. Die komplexe Implementierung stellt jedoch vor allem kleine und mittlere Unternehmen (KMU) vor große Herausforderungen. Dies führt dazu, dass viele KMU auf die Nutzung von Machine-Learning-Anwendungen verzichten. Daher befasst sich das IPH – Institut für Integrierte Produktion gemeinsam mit dem IPRI – International Performance Research Institute in dem Forschungsprojekt „MLready“ mit der Entwicklung einer Einführungsstrategie, die KMU dazu befähigen soll, Machine Learning einfach und effizient implementieren und nutzen zu können.
A glycine zipper motif is required for the translocation of a T6SS toxic effector into target cells
Authors: Ali Jemal , Yu Manda , Sung Li‐Kang , Cheung Yee‐Wai , Lai Erh‐Min 
Published: April 2023

AbstractType VI secretion systems (T6SSs) can deliver diverse toxic effectors into eukaryotic and bacterial cells. Although much is known about the regulation and assembly of T6SS, the translocation mechanism of effectors into the periplasm and/or cytoplasm of target cells remains elusive. Here, we use the Agrobacterium tumefaciens DNase effector Tde1 to unravel the mechanism of translocation from attacker to prey. We demonstrate that Tde1 binds to its adaptor Tap1 through the N‐terminus, which harbors continuous copies of GxxxG motifs resembling the glycine zipper structure found in proteins involved in the membrane channel formation. Amino acid substitutions on G39xxxG43 motif do not affect Tde1–Tap1 interaction and secretion but abolish its membrane permeability and translocation of its fluorescent fusion protein into prey cells. The data suggest that G39xxxG43 governs the delivery of Tde1 into target cells by permeabilizing the cytoplasmic membrane. Considering the widespread presence of GxxxG motifs in bacterial effectors and pore‐forming toxins, we propose that glycine zipper‐mediated permeabilization is a conserved mechanism used by bacterial effectors for translocation across target cell membranes.
The Effect of the Game-Based Learning Model on Student Engagement in History Learning
Authors: Rahmawati Vini , Umamah Nurul , Sumardi Sumardi , Marjono Marjono 
Published: April 2023

This study aimed to examine the effect of the game-based learning model on student engagement in history learning. A quasi-experimental design with a post-test-only model and a non-equivalent control-group design was used to verify the effect of the two variables. The sample consisted of 66 students in classes XI IPS 4 and XI IPS 1 at SMA Negeri 1 Gambiran, obtained through a homogeneity test. The data were collected using documentation and questionnaires. The data analysis technique used one-way ANOVA and LSD (Least Significant Difference) follow-up test with the help of SPSS 22.0 software for Windows. Data analysis results showed that there was an effect of applying the game-based learning model on student engagement in history classrooms. The results of the one-way ANOVA test showed that the probability value (sig.) in the experimental group was 0.040 0.05, with the LSD follow-up test LSD of 2.45455. Therefore, it is concluded that there was an effect of student engagement on the experimental group taught using the game-based learning model. This research recommends that the game-based learning model can be a reference for improving student engagement, active learning, and student-centered learning so that the learning process becomes fun, interactive, communicative, collaborative, and able to maximize the role of technology in education.Keywords: Education 4.0, game-based learning, student engagementPenelitian ini bertujuan untuk menguji pengaruh penerapan model game-based learning terhadap student engagement pada mata pelajaran sejarah. Desain quasi experimental dengan model post-test-only , non-equivalent control-group design digunakan untuk memverifikasi pengaruh kedua variabel. Sampel terdiri dari 66 peserta didik pada kelas XI IPS 4 dan XI IPS 1 di SMA Negeri 1 Gambiran, yang diperoleh melalui uji homogenitas. Pengumpulan data menggunakan dokumentasi dan angket. Teknik analisis data menggunakan one-way anova dan uji lanjut LSD (Least Significant Difference) berbantuan software SPPS 22 for Windows. Hasil analisis data menunjukkan bahwa terdapat pengaruh penerapan model game-based learning terhadap student engagement pada mata pelajaran sejarah. Hasil uji one-way anova menunjukkan probabilitas value (sig.) pada kelompok eksperimen sebesar 0.040 0.05, dengan uji lanjut LSD sebesar 2,45455. Sehingga disimpulan bahwa terdapat pengaruh student engagement pada kelompok eksperimen yang dibelajarkan menggunakan model game-based learning. Rekomendasi penelitian ini adalah model game-based learning mampu menjadi acuan untuk meningkatkan student engagement, karena pembelajaran aktif, student-centered learning sehingga proses pembelajaran menjadi menyenangkan, interaktif, komunikatif, kolaboratif, dan mampu memaksimalkan peran teknologi dalam pembelajaran.Keywords: Pendidikan 4.0, game-based learning, student engagement
Between Women, Throne, and Power: Religious Transformation in Kagaua Palu, 1600-1904
Authors: Nuraedah Nuraedah 
Published: April 2023

This study examines the discourse of women, the throne, and power as a foundation for thinking that led to the transformation of religion in Kagaua Palu’s history from 1600 to 1904. Few studies on women reveal its connection with the change of Islam in Palu. This study uses a qualitative-historical method with heuristic stages, source criticism, interpretation, and historiography. The data sources for this research are colonial manuscripts, newspapers, and some utterances (oral information). The study shows that religious transformation drives tradition in Kagaua Palu to experience a shift, seen from the shifting matrilineal system to the patrilineal, even though this does not apply in general. In addition, the religious transformation has also led to a shift in local cultural awareness and the birth of a dynamic Islamic understanding that has opened the broadest possible access. In general, the To Kaili woman has become a pillar of the forerunner to the throne and power, accompanied by a religious transformation in Kagaua Palu. In conclusion, To Kaili women are essential in developing Palu Muslim society. That becomes a comparative narrative that erodes patriarchal nuances in Indonesian historiography.Keywords: Woman, Throne and Power, Religious Transformation, Kagaua PaluKajian ini mengkaji wacana perempuan, tahta, dan kekuasaan sebagai landasan pemikiran yang berujung pada transformasi agama dalam sejarah Kagaua Palu dari tahun 1600 hingga 1904. Beberapa kajian tentang perempuan mengungkap keterkaitannya dengan perubahan Islam di Palu. Penelitian ini menggunakan metode kualitatif-historis dengan tahapan heuristik, kritik sumber, interpretasi, dan historiografi. Sumber data untuk penelitian ini adalah manuskrip kolonial, surat kabar, dan beberapa ucapan (informasi lisan). Studi ini menunjukkan bahwa transformasi agama mendorong tradisi di Kagaua Palu mengalami pergeseran, terlihat dari pergeseran sistem matrilineal ke patrilineal, meskipun hal ini tidak berlaku secara umum. Selain itu, transformasi keagamaan juga telah menyebabkan terjadinya pergeseran kesadaran budaya lokal dan lahirnya pemahaman Islam yang dinamis sehingga membuka akses seluas-luasnya. Secara umum, perempuan To Kaili telah menjadi pilar cikal bakal tahta dan kekuasaan, disertai dengan transformasi agama di Kagaua Palu. Kesimpulannya, To Kaili perempuan sangat penting dalam membangun masyarakat Muslim Palu. Itu menjadi narasi komparatif yang mengikis nuansa patriarki dalam historiografi Indonesia.Kata kunci: Perempuan, Takhta dan Kekuasaan, Transformasi Keagamaan, Kagaua Palu
Making Yogurt: A Practical Study to Develop an Understanding of Useful Bacteria
Authors: Üçüncü Gökşen , Karakaya Ferhat , Yilmaz Mehmet 
Published: April 2023

This study aims for students to comprehend the beneficial functions of bacteria with the traditional home yogurt leavening activity. Also, it aims to identify alternative concepts related to leavening and contribute to students' home yogurt consumption habits. The study is a case study. The study was conducted with 29 fifth-grade students studying at a public school in Istanbul in the 2019-2020 academic year and their parents. Questionnaire forms and student observation forms developed by the researchers were used as data collection tools. The obtained data were described by content analysis. Before the application, the participant students were given these three statements; microbes as a sample of microscopic creatures, yeast fungi caused yogurt formation, and yogurt is healthy because it was a dairy product. While after the application, participant students changed their statements to these three; the term microbe was not used as a sample of microscopic creatures, bacteria took part in the formation of yogurt, and yogurt is healthy because it contains microscopic creatures beneficial for the digestive system. The educational activities integrated into daily life contribute to students' conceptual learning.
Determining the Cognitive Structures of Secondary School Students on COVID-19
Authors: Çıngıl Barış Çiğdem 
Published: April 2023

This research aims to determine the cognitive structures of secondary school students about COVID-19. In this research, a case study, one of the qualitative research methods, was used, and demographic information and a word association test were the data sources. The study group of the research consists of 226 students who continue their education in the 6th and 7th grades of a public secondary school. The data were collected via Google Form, and the obtained data were analyzed by content analysis. The cognitive structures of secondary school students on the concept of COVID-19 are grouped under 11 categories. These categories are COVID-19 Prevention Methods, COVID-19 Reflections in Press, COVID-19 Results, COVID-19 Perceptions, Causes of COVID-19 Transmission, COVID-19 Treatment, COVID-19 Symptoms, Countries where COVID-19 are Common, Characteristics of COVID-19, COVID-19 Carriers and COVID-19 Diagnostic Ways. When these categories were examined, it was seen that the students' cognitive structures about the concept of COVID-19 focused on COVID-19 Prevention Methods, COVID-19 Reflections in Press, COVID-19 Results, and COVID-19 Perceptions. In addition, it has been determined that some students have misconceptions about the COVID-19 virus.
A Formação do Pedagogo na Modalidade a Distância: Reconfigurações em Tempos de Pandemia
Authors: Marcon Karina , Goedert Lidiane 
Published: April 2023

Este artigo socializa os dados de uma pesquisa diagnóstica realizada com estudantes e equipe docente (professores e tutores) do curso de Pedagogia na modalidade a distância do Centro de Educação a Distância da Universidade do Estado de Santa Catarina (CEAD/UDESC), desenvolvida por meio de um questionário online tipo survey que teve a finalidade de identificar o acesso às tecnologias digitais de rede e à internet pelos estudantes e equipe docente do curso, para organizar e retomar as atividades de ensino que haviam sido interrompidas em função da Pandemia de Covid-19. Nesse sentido, enquanto gestão do curso de Pedagogia, buscamos mapear o acesso à infraestrutura tecnológica e levantar as dificuldades encontradas por eles neste processo. Sendo assim, neste texto sinalizamos as mudanças implementadas ao longo do ano de 2020, os encaminhamentos para a retomada das atividades de ensino e o acompanhamento realizado ao longo do ano, bem como as considerações da gestão sobre as mudanças ocorridas a partir do diagnóstico realizado. Os resultados evidenciam que a pandemia alterou a rotina de estudos e de outras dimensões do cotidiano das pessoas; apressou processos de inclusão digital; que os agentes educativos do curso de Pedagogia analisado sofreram com dificuldades de acesso à internet, falta de equipamentos ou com um acesso com baixa qualidade de conexão, além de demonstrar a necessidade de formação continuada pelos estudantes e equipe docente do curso.

Palavras-chave: Educação a distância. Pandemia. Pedagogia. Formação de professores.