bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dreaming of God and the Role of Faith in Everyday Life: An Empirical Study
Authors: Schredl Michael , Mönch Jan-Hendrik 
Published: June 2023

AbstractIn Christian faith, dreams – at least some – have been seen as messages from God; very powerful examples can be found in the Bible. However, empirical research regarding dreams of God is relatively scarce. Four hundred and fifty-two persons participated in the present survey, including a group from theology-related professions (theology students, priests, etc.). The findings indicate that the belief that dreams can be messages from God is related to the importance of faith in the everyday life of the dreamer and a positive attitude towards dreams. About 20% of the participants reported having dreams about encountering God, which was related to their waking life religiosity. On the one hand, the findings support the continuity hypothesis of dreaming, that is, that dreaming reflects waking life, while, on the other hand, these special dreams might help the dreamer to deepen their faith. Longitudinal studies are necessary to study this bidirectional relationship between waking life faith and religious dreams.
Associations between treatments, comorbidities and multidimensional aspects of quality of life among patients with advanced cancer in the Netherlands—a 2017–2020 multicentre cross-sectional study
Authors: Malhotra Ananya , Fransen Heidi P. , Quaresma Manuela , Raijmakers Natasja , Versluis Moyke A. J. , Rachet Bernard , van Maaren Marissa C. , Leyrat Clémence 
Published: June 2023

Abstract
Objective
To investigate associations between quality of life (QoL) and 1) immunotherapy and other cancer treatments received three months before QoL measurements, and 2) the comorbidities at the time of completion or in the year prior to QoL measurements, among patients with advanced cancer.

Methods
A cross-sectional study is conducted on patients with advanced cancer in the Netherlands. The data come from the baseline wave of the 2017–2020 eQuiPe study. Participants were surveyed via questionnaires (including EORTC QLQ-C30). Using multivariable linear and logistic regression models, we explored statistical associations between QoL components and immunotherapy and other cancer treatments as well as pre-existing comorbidities while adjusting for age, sex, socio-economic status.

Results
Of 1088 participants with median age 67 years, 51% were men. Immunotherapy was not associated with global QoL but was associated with reduced appetite loss (odds ratio (OR) = 0.6, 95%CI = [0.3,0.9]). Reduced global QoL was associated with chemotherapy (adjusted mean difference (β) = − 4.7, 95% CI [− 8.5,− 0.8]), back pain (β = − 7.4, 95% CI [− 11.0,− 3.8]), depression (β = − 13.8, 95% CI [− 21.5,− 6.2]), thyroid diseases (β = − 8.9, 95% CI [− 14.0,− 3.8]) and diabetes (β = − 4.5, 95% CI [− 8.9,− 0.5]). Chemotherapy was associated with lower physical (OR = 2.4, 95% CI [1.5,3.9]) and role (OR = 1.8, 95% CI [1.2,2.7]) functioning, and higher pain (OR = 1.9, 95% CI [1.3,2.9]) and fatigue (OR = 1.6, 95% CI [1.1,2.4]).

Conclusion
Our study identified associations between specific cancer treatments, lower QoL and more symptoms. Monitoring symptoms may improve QoL of patients with advanced cancer. Producing more evidence from real life data would help physicians in better identifying patients who require additional supportive care.
Delivery room resuscitation intensity and associated neonatal outcomes of 24+0–31+6 weeks’ preterm infants in China: a retrospective cross-sectional study
Authors: Wang Si-Lu , Chen Chun , Gu Xin-Yue , Yin Zhao-Qing , Su Le , Jiang Si-Yuan , Cao Yun , Du Li-Zhong , Sun Jian-Hua , Liu Jiang-Qin , Yang Chuan-Zhong ,   Chinese Neonatal Network Investigators
Published: June 2023

Abstract
Background
The aim of this study was to review current delivery room (DR) resuscitation intensity in Chinese tertiary neonatal intensive care units and to investigate the association between DR resuscitation intensity and short-term outcomes in preterm infants born at 24+0–31+6 weeks’ gestation age (GA).

Methods
This was a retrospective cross-sectional study. The source population was infants born at 24+0–31+6 weeks’ GA who were enrolled in the Chinese Neonatal Network 2019 cohort. Eligible infants were categorized into five groups: (1) regular care; (2) oxygen supplementation and/or continuous positive airway pressure (O2/CPAP); (3) mask ventilation; (4) endotracheal intubation; and (5) cardiopulmonary resuscitation (CPR). The association between DR resuscitation and short-term outcomes was evaluated by inverse propensity score-weighted logistic regression.

Results
Of 7939 infants included in this cohort, 2419 (30.5%) received regular care, 1994 (25.1%) received O2/CPAP, 1436 (18.1%) received mask ventilation, 1769 (22.3%) received endotracheal intubation, and 321 (4.0%) received CPR in the DR. Advanced maternal age and maternal hypertension correlated with a higher need for resuscitation, and antenatal steroid use tended to be associated with a lower need for resuscitation (P < 0.001). Severe brain impairment increased significantly with increasing amounts of resuscitation in DR after adjusting for perinatal factors. Resuscitation strategies vary widely between centers, with over 50% of preterm infants in eight centers requiring higher intensity resuscitation.

Conclusions
Increased intensity of DR interventions was associated with increased mortality and morbidities in very preterm infants in China. There is wide variation in resuscitative approaches across delivery centers, and ongoing quality improvement to standardize resuscitation practices is needed.
Exploring the Binding Mechanism of NRG1–ERBB3 Complex and Discovery of Potent Natural Products to Reduce Diabetes-Assisted Breast Cancer Progression
Authors: Marafie Sulaiman K. , Alshawaf Eman , Abu-Farha Mohamed , Thanaraj Thangavel Alphonse , Wei Dong-Qing , Al-Mulla Fahd , Khan Abbas , Abubaker Jehad , Mohammad Anwar 
Published: June 2023

AbstractDiabetes mellitus significantly contributes to breast cancer progression, where hyperglycemia upregulates specific genes, leading to more aggressive tumor growth. In patients with BC that develop diabetes, neuregulin 1 (NRG1) and epidermal growth factor receptor 3 (ERBB3) overexpression exacerbate tumor growth and progression. Since the interaction between NRG1 and ERBB3 is critical for tumor growth, understanding the molecular mechanisms underlying NRG1–ERBB3 complex formation is essential for elucidating diabetes-assisted breast cancer progression. However, the key residues forming the NRG1–ERBB3 complex remain unknown. Here, we substituted specific residues in NRG1 with alanine and studied its interactions with ERBB3 using computational structural biology tools. We further screened the South African natural compounds database to target the complex’s interface residues to discover potential inhibitors. The conformational stability and dynamic features of NRG1–WT, –H2A, –L3A, and –K35A complexed with ERBB3 were subjected to 400 ns molecular dynamics simulations. The free binding energies of all NRG1–ERBB3 complexes were calculated using the molecular mechanics-generalized Born surface area (MM/GBSA). The H2 and L3 alanine substitutions caused a loss of interaction with ERBB3 residue D73, weakening the interaction with ERBB3. Screening 1300 natural compounds identified four (SANC00643, SANC00824, SANC00975, and SANC00335) with the best potential to inhibit ERRB3-NRG1 coupling. The binding free energies for each complex were − 48.55 kcal/mol for SANC00643, − 47.68 kcal/mol for SANC00824, − 46.04 kcal/mol for SANC00975, and − 45.29 kcal/mol for SANC00335, showing their overall stronger binding with ERBB3 than NRG1 and their potential to act as ERBB3-NRG1 complex inhibitors. In conclusion, this complex may represent a residue-specific drug target to inhibit BC progression.Graphical abstract
What is a fire resilient landscape? Towards an integrated definition
Authors: Thacker Fiona E. Newman , Ribau Marc Castellnou , Bartholomeus Harm , Stoof Cathelijne R. 
Published: June 2023

AbstractThe concept of fire resilience has become increasingly relevant as society looks to understand and respond to recent wildfire events. In particular, the idea of a ‘fire resilient landscape’ is one which has been utilised to explore how society can coexist with wildfires. However, the concept of fire resilient landscapes has often been approached in silos, either from an environmental or social perspective; no integrated definition exists. Based on a synthesis of literature and a survey of scientists and practitioners, we propose to define a fire resilient landscape as ‘a socio-ecological system that accepts the presence of fire, whilst preventing significant losses through landscape management, community engagement and effective recovery.’ This common definition could help guide policy surrounding fire resilient landscapes, and exemplify how such landscapes could be initiated in practice. We explore the applicability of the proposed definition in both Mediterranean and temperate Europe.
Co-production of high density biomass and high-value compounds via two-stage cultivation of Chlorella vulgaris using light intensity and a combination of salt stressors
Authors: El-fayoumy Eman A. , Ali Hamdy Elsayed Ahmed , Elsaid Khaled , Elkhatat Ahmed , Al-Meer Saeed , Rozaini Mohd Zul Helmi , Abdullah Mohd Azmuddin 
Published: June 2023

AbstractIn this study, the effects of combined stress factors involving light intensity and salinity (NaCl, MgCl2, CaCl2, and their combinations) on the two-stage cultivation of Chlorella vulgaris for simultaneous production of biomass and high-value products, were investigated. The two-stage strategies comprised a 25-day vegetative stage in BG11 medium, followed by a 15-day combined stress stage. During salt stress conditions, the addition of 15 g L−1 CaCl2 or 7.5 g L−1 MgCl2 / 7.5 g L−1 CaCl2 mixture with 140 µmol m−2 s−1 light intensity significantly promoted the growth of C. vulgaris achieving maximum biomass productivity of 50.50 ± 0.50 and 50.25 ± 3.25 mg L−1 d−1, respectively. Cultivation of C. vulgaris in a medium containing 7.5 g L−1 NaCl/ 7.5 g L−1 CaCl2 had remarkably increased the lipid content (31.15 ± 1.18%) and lipid productivity (14.55 ± 1.48 mg L−1 d−1). The saturated fatty acids (SFAs) at 39.52–59.29%, monounsaturated fatty acids (MUFAs) at 27.16–35.47%, and polyunsaturated fatty acids (PUFAs) at 7.18–29.97%, were obtained with palmitic (C16:0), oleic (C18:1), stearic (C18:0), and linolenic (C18:3) acids as predominant fatty acids. Cultures supplemented with 5 g L−1 NaCl / 5 g L−1 MgCl2 / 5 g L−1 CaCl2 and high light intensity exposure attained consistently high carbohydrate content (52.71 ± 2.50%). The combination of 7.5 g L−1 NaCl / 7.5 g L−1 MgCl2 also resulted in a marked increase in the protein content (35.32 ± 2.20%) and total carotenoids (0.31 ± 0.03 μg mL−1) as compared to the Controls. The highest antioxidant activity (86.16%) was achieved with a 7.5 g L−1 NaCl / 7.5 g L−1 CaCl2 combination in the growth stage. The antioxidant activities were attributed to the presence of phenolics, flavonoids, and tannins due to the stressed conditions. One of the key benefits of using a combined stress strategy in this study is that if one factor has a low impact on enhancing target metabolites, other factors can compensate.
Sicherheitsaspekte bei der Behandlung mit Clozapin
Authors: Berger Stefan J. , Hofer Alex 
Published: June 2023

Zusammenfassung
Hintergrund
Auf Grund seiner unvergleichbaren Wirksamkeit bei therapieresistenten schizophrenen Störungen ist der Abbruch einer Behandlung mit Clozapin häufig mit einer erheblichen Verschlechterung der Krankheitssymptomatik, aber auch mit einem erhöhten Suizidrisiko verbunden. Ziel der vorliegenden Übersichtsarbeit ist es, auf Basis aktueller Fachliteratur verschiedene Monitoring-Empfehlungen zusammen zu fassen, um diese Therapie gegebenenfalls trotz auftretender unerwünschter Arzneimittelwirkungen (UAW) fortsetzen zu können. Des Weiteren wird ausgearbeitet, wann eine unterbrochene Therapie mit Clozapin wieder aufgenommen werden kann (Rechallenge) und wann ein definitiver Behandlungsabbruch erfolgen muss.

Material und Methoden
Die Datenbank Medline sowie die Guideline for the use of clozapine 2013 der Netherlands Clozapine Collaboration Group und die S3-Behandlungsleitlinie Schizophrenie der Deutschen Gesellschaft für Psychiatrie und Psychotherapie, Psychosomatik und Nervenheilkunde e.V. wurden nach relevanter Literatur untersucht, die letzte Abfrage erfolgte am 28.04.2023.

Resultate
Bei Entwicklung einer Agranulozytose oder einer Kardiomyopathie muss die Behandlung mit Clozapin beendet werden und sollte auch im weiteren Verlauf nicht wieder aufgenommen werden. Dem gegenüber kann eine auf Grund einer Myokarditis bzw. einer unter der Behandlung auftretenden Verlängerung der QTc-Zeit abgebrochene Behandlung mit Clozapin bei regelrechter linksventrikulärer Funktion bzw. nach Normalisierung der QTc-Zeit gegebenenfalls fortgesetzt werden. Andere UAW stellen in der Regel keine absolute Kontraindikation für eine Rechallenge dar, erfordern jedoch häufig den adjuvanten Einsatz zusätzlicher pharmakologischer und nicht-pharmakologischer Maßnahmen.

Schlussfolgerung
Unter Berücksichtigung verschiedener Monitoring-Empfehlungen kann die Beendigung einer Behandlung mit Clozapin häufig verhindert bzw. eine auf Grund von UAW abgebrochene Behandlung mit Clozapin wieder aufgenommen werden.
The transcription factor HBF1 directly activates expression of multiple flowering time repressors to delay rice flowering
Authors: Li Cong , Zhang Liya , Wang Xin , Yu Chunsheng , Zhao Tao , Liu Bin , Li Hongyu , Liu Jun , Zhang Chunyu 
Published: June 2023

AbstractFlowering time (or heading date) is an important agronomic trait that determines the environmental adaptability and yield of many crops, including rice (Oryza sativa L.). Hd3a BINDING REPRESSOR FACTOR 1 (HBF1), a basic leucine zipper transcription factor, delays flowering by decreasing the expression of Early heading date 1 (Ehd1), Heading date 3a (Hd3a), and RICE FLOWERING LOCUS T 1 (RFT1), but the underlying molecular mechanisms have not been fully elucidated. Here, we employed the hybrid transcriptional factor (HTF) strategy to enhance the transcriptional activity of HBF1 by fusing it to four copies of the activation domain from Herpes simplex virus VP16. We discovered that transgenic rice lines overexpressing HBF1-VP64 (HBF1V) show significant delays in time to flower, compared to lines overexpressing HBF1-MYC or wild-type plants, via the Ehd1–Hd3a/RFT1 pathway, under both long-day and short-day conditions. Transcriptome deep sequencing analysis indicated that 19 WRKY family genes are upregulated in the HBF1V overexpression line. We demonstrate that the previously unknown gene, OsWRKY64, is a direct downstream target of HBF1 and represses flowering in rice, whereas three known flowering repressor genes, Days to heading 7 (DTH7), CONSTANS 3 (OsCO3), and OsWRKY104, are also direct target genes of HBF1 in flowering regulation. Taking these results together, we propose detailed molecular mechanisms by which HBF1 regulates the time to flower in rice.
Investigation of physico-chemical properties and evaluation of the biological potential of essential oil extracted from Artemisia pallens
Authors: Jha Vikas , Kadam Purvesh , Jain Tisha , Bhargava Agraj , Marick Arpita , Saiya Badal , Maiti Sathi , Pandya Siddhartha , Patel Reetikesh , Jadhav Namrata 
Published: June 2023

AbstractArtemisia pallens, an aromatic and medicinal plant occasionally referred to as Davana is a member of the Asteraceae family. Understanding the physiochemical and therapeutic properties of Davana essential oil (DEO) is the major aim of this study. Essential oil from plant material was extracted using the hydro-distillation method. Examination of the phytochemical components and several plant constituents from the whole oil were detected using GC–MS analysis and some components were Isobutyl propionate, 4,5-Dimethyl-Thiazole, Ligustrazin, Endo-2-Norborneol, Tetradecanoic acid, and Octadecanoic acid. The thermal stability of the oil was tested using thermoanalytical studies such as TG–DTA and DSC. Moreover, to comprehend the biological potential of the oil antimicrobial, antituberculosis, antimalarial, antioxidant, anticancer, and antibiofilm activities were investigated essential oil was tested for antimicrobial activity against 10 bacterial and 7 fungal strains. The antimalarial potential was evaluated against Plasmodium falciparum. Cytotoxicity of the DEO was determined against MCF-7, HeLa, and CHO cell lines employing MTT assay. Meanwhile, the DPPH assay was adopted to assess antioxidant potential, and the ability to suppress biofilm formation was also assessed. The study’s findings reveal that Artemisia pallens is a reservoir of natural compounds and can be used against numerous ailments.
Ciprofloxacin analogues: drug likeness, biological and molecular docking studies
Authors: Asghar Basim H. , Arshad Mohammad 
Published: June 2023

AbstractThe search for new antimicrobial agents due to the development of antimicrobial resistance is one of the greatest points of concern among medicinal chemists. It has been observed that the infections due to the antimicrobial resistance pathogens are one of the reasons for the mortality. Therefore, it is really important to find out some new low molecular weight antimicrobial drugs with different mode of action. Despite of being a better antibiotic, ciprofloxacin represented resistance against many pathogens. Herein, this study reported the synthesis of novel analogues of ciprofloxacin (1) including 1,3,4-oxadiazole, thiazolidine-4-one, 1,3,4-oxazoline, 1,2,4-triazole, Schiff's base, hydrazide, and 1,3,4-thiadiazole (2–8), following their computational assessment. All analogues were then synthesized and characterized using FT-IR, NMR, Mass spectroscopy, etc. The prepared analogs were then assessed for antimicrobial properties against bacterial pathogens and fungal isolates using disc diffusion and serial dilution methodology. To observe the toxicity of the prepared analogs the MTT assay was performed against HepG2 cells. The receptor glucosamine-6-phosphatase (GlcN-6P) and lanosterol 14-alpha-demethylase (CYP51) were used for the molecular docking assay using Auto Dock Tools-1.5.6 to evaluate the degree of hydrogen bonding and binding affinities. It was observed that analogue (2) established strong hydrogen bonds with the both receptors, with great binding affinities.
Neuro-cognitive complications of nephropathic cystinosis
Authors: Trauner Doris A. 
Published: June 2023

Abstract
Purpose
To review the neuro-cognitive complications of nephropathic cystinosis.

Methods
Review of published information on neurological and cognitive complications of cystinosis.

Results
Nephropathic cystinosis is a rare disorder of cystine metabolism. Although renal failure is the earliest and most severe complication of this condition, all organs of the body eventually become involved. The brains of children with cystinosis demonstrate structural changes early in life. Neuro-cognitive differences, including motor incoordination and visual spatial dysfunction, are present from early life and may negatively impact learning. Executive functioning is also impaired and this may contribute to poor adherence to medication regimens.

Conclusions
Early recognition of these difficulties allows for intervention to minimize problems associated with the neurocognitive deficits in cystinosis.
A Monte Carlo algorithm for the extrema of tempered stable processes
Authors: González Cázares Jorge Ignacio , Mijatović Aleksandar 
Published: June 2023

AbstractWe develop a novel Monte Carlo algorithm for the vector consisting of the supremum, the time at which the supremum is attained, and the position at a given (constant) time of an exponentially tempered Lévy process. The algorithm, based on the increments of the process without tempering, converges geometrically fast (as a function of the computational cost) for discontinuous and locally Lipschitz functions of the vector. We prove that the corresponding multilevel Monte Carlo estimator has optimal computational complexity (i.e. of order
$\varepsilon^{-2}$
if the mean squared error is at most
$\varepsilon^2$
) and provide its central limit theorem (CLT). Using the CLT we construct confidence intervals for barrier option prices and various risk measures based on drawdown under the tempered stable (CGMY) model calibrated/estimated on real-world data. We provide non-asymptotic and asymptotic comparisons of our algorithm with existing approximations, leading to rule-of-thumb principles guiding users to the best method for a given set of parameters. We illustrate the performance of the algorithm with numerical examples.
Investing in Nutrition: A Global Best Investment Case
Authors: Larsen Bjorn , Hoddinott John , Razvi Saleema 
Published: June 2023

AbstractUndernutrition and micronutrient deficiencies are key drivers of infant and child mortality and are causes of impaired human potential for hundreds of millions of children every year. Investing in nutrition in the first 1,000 days from conception not only supports individual lifetime health, education, and productivity, but is also key to breaking the intergenerational cycle of malnutrition and enhance equitable development pathways for low- and middle-income countries. This paper provides a cost–benefit analysis of three nutrition interventions: 1) provision of preventive small-quantity lipid-based nutrient supplements (SQ-LNS) to children 6−23 months of age; 2) Complementary Feeding Promotion (CFP) for children 6−23 months of age; 3) provision of multiple micronutrient (MMN) and calcium (Ca) supplements to pregnant women. The benefit–cost ratios (BCRs) for MMN supplementation for pregnant women replacing iron and folic acid (37.5), as well as MMN and Ca combined (19-24), are the highest. The BCRs for CFP for children in the two highest socio-economic status (SES) quintiles and SQ-LNS for children in the three lowest SES quintiles are fairly similar at 16 and 14, respectively. The lowest BCR is for CFP for children in the three lowest SES quintiles due to the high cost of accomplishing behavioral change for improved complementary feeding in resource-poor households.