bluuebunny/crossref_metadata_2025_split huggingface dataset:
What explains inconsistencies in field‐based ecosystem mapping?
Authors: Naas Adam Eindride , Halvorsen Rune , Horvath Peter , Wollan Anders Kvalvåg , Bratli Harald , Brynildsrud Katrine , Finne Eirik Aasmo , Keetz Lasse Torben , Lieungh Eva , Olson Christine , Simensen Trond , Skarpaas Olav , Tandstad Hilde Riksheim , Torma Michal , Værland Espen Sommer , Bryn Anders 
Published: February 2023

AbstractQuestionsField‐based ecosystem mapping is prone to observer bias, typically resulting in a mismatch between maps made by different mappers, that is, inconsistency. Experimental studies testing the influence of site, mapping scale, and differences in experience level on inconsistency in field‐based ecosystem mapping are lacking. Here, we study how inconsistencies in field‐based ecosystem maps depend on these factors.LocationIškoras and Guollemuorsuolu, northeastern Norway, and Landsvik and Lygra, western Norway.MethodsIn a balanced experiment, four sites were field‐mapped wall‐to‐wall to scales 1:5000 and 1:20,000 by 12 mappers, representing three experience levels. Thematic inconsistency was calculated by overlay analysis of map pairs from the same site, mapped to the same scale. We tested for significant differences between sites, scales, and experience‐level groups. Principal components analysis was used in an analysis of additional map inconsistencies and their relationships with site, scale and differences in experience level and time consumption were analysed with redundancy analysis.ResultsOn average, thematic inconsistency was 51%. The most important predictor for thematic inconsistency, and for all map inconsistencies, was site. Scale and its interaction with site predicted map inconsistencies, but only the latter were important for thematic inconsistency. The only experience‐level group that differed significantly from the mean thematic inconsistency was that of the most experienced mappers, with nine percentage points. Experience had no significant effect on map inconsistency as a whole.ConclusionThematic inconsistency was high for all but the dominant thematic units, with potentially adverse consequences for mapping ecosystems that are fragmented or have low coverage. Interactions between site and mapping system properties are considered the main reasons why no relationships between scale and thematic inconsistency were observed. More controlled experiments are needed to quantify the effect of other factors on inconsistency in field‐based mapping.
Recognition of facial emotions across the lifespan: 8‐year‐olds resemble older adults
Authors: Ruffman Ted , Kong Qiuyi , Lim Hui Mei , Du Kangning , Tiainen Emilia 
Published: February 2023

AbstractOn standard emotion recognition tasks with relatively long or unlimited stimuli durations, recognition improves as children grow older, whereas older adults are worse than young adults. Crucially, it was unknown (a) how older adults compare to age groups below young adulthood and (b) whether children can recognize emotions at shorter durations, with short durations likely common in real life. We compared emotion recognition in 5‐year‐olds, 8‐year‐olds, young adults and older adults at very brief durations (50 ms, 250 ms) as well as standard unlimited durations. Eight‐year‐olds were better than 5‐year‐olds, young adults than all groups, and there was a striking similarity between 8‐year‐olds and older adults, providing the first clear indication that older adults' recognition abilities are equivalent to that of an 8‐year‐old at all durations. Emotion recognition was above chance on all emotions and durations among the three older age groups and on most stimuli for 5‐year‐olds.
A shift towards collaboration: Examining practitioner's economic development practices in Ontario during the COVID‐19 pandemic
Authors: Sutton Jesse , Arku Godwin , Oosterbaan Catherine 
Published: February 2023

AbstractRegional collaboration has been suggested as a more effective way to promote economic development than competitive approaches. In Ontario, despite attempts by the provincial government to encourage regional collaboration, research finds that municipalities are still engaging in inter‐territorial competition. In this article, we conducted interviews with thirty‐seven practitioners to determine if economic development practices in Ontario have shifted towards more collaborative approaches during the COVID‐19 pandemic. The article finds that regional collaboration, as an economic development practice, has intensified in the province during the recent pandemic. Practitioners noted three reasons for engaging in regional collaboration: pool resources, reduce duplication, and complete regionally task‐oriented goals.
Estrone analogs as potential inhibitors targeting EGFR‐MAPK pathway in non‐small‐cell lung cancer
Authors: Acheampong Felix , Ostlund Trevor , Mahnashi Mater , Halaweish Fathi 
Published: February 2023

AbstractLung cancer is the deadliest human cancer globally, with non‐small‐cell lung cancer (NSCLC) being the most frequent type. Epidermal growth factor receptor (EGFR), a central regulator of tumor progression is frequently overexpressed in NSCLC and is a key drug target along with its downstream pathways. Here, we describe the biological evaluation of previously synthesized estrone analogs as potent inhibitors of NCI‐H226 cells. Two of the analogs, MMA307 and MM320, significantly inhibited the proliferation of NCI‐H226 cells with IC50 doses of 2.88 ± 0.21 and 9.68 ± 0.24 μM, respectively, compared with the positive control and chemotherapy, sorafenib, IC50 of 20.62 ± 1.32 μM. Exposing NCI‐H226 cells to IC50 concentration of MMA307 and MMA320 resulted in the downregulation of EGFR and phospho‐EGFR expression levels, and suppression of activated MAPK‐ERK1/2 signaling proteins; phospho‐B‐Raf, phospho‐MEK1/2, and phospho‐ERK1/2. Furthermore, the downregulation of cyclin D1 and concomitant upregulation of phospho‐cyclin D1 and p21waf1/cip1 were observed after the compounds' addition to NCI‐H226 cells resulting in G1 phase cell cycle arrest. MMA320 but not MMA307 downregulated the expression levels of Dyrk1B, a checkpoint kinase at the G1–S phase transition of the cell cycle. Additionally, molecular dynamic simulations were performed and found that MMA307 and MMA320 have higher binding affinities than sorafenib in MEK, BRAF, cyclin D1, and Dyrk1B (dual‐specificity tyrosine phosphorylation‐regulated kinase 1B). To conclude, the present study is the first to report on the antiproliferative potential of novel estrone analogs and provide evidence that MMA307 and MMA320 are promising novel lead candidates for the development of antilung cancer drugs.
Teacher depressive symptoms and children's school readiness in Ghana
Authors: Peele Morgan , Wolf Sharon , Behrman Jere R. , Aber J. Lawrence 
Published: February 2023

AbstractThis study investigated associations between kindergarten teachers' (N = 208) depressive symptoms and students' (Ghanaian nationals, N = 1490, Mage = 5.8) school‐readiness skills (early literacy, early numeracy, social–emotional skills, and executive function) across 208 schools in Ghana over one school year. Teachers' depressive symptoms in the fall negatively predicted students' overall school‐readiness skills in the spring, controlling for school‐readiness skills in the fall. These results were primarily driven by social–emotional skills (r = .1–.3). There was evidence of heterogeneity by students' fall skill levels; teacher depressive symptoms predicted more negative spring overall school readiness for children who had higher fall school‐readiness skills. Findings underscore the importance of teachers' mental health in early childhood education globally, with implications for policy and practice.
Hypersensitivity to permanent tattoos: Literature summary and comprehensive review of patch tested tattoo patients 1997–2022
Authors: Schubert Steffen , Kluger Nicolas , Schreiver Ines 
Published: February 2023

AbstractWe outline constituents of tattoo and permanent make‐up ink with regard to inflammatory tattoo reactions and population‐based confounders. The comprehensive review of patch‐tested tattoo patients between 1997 and 2022 shows that tattoo allergy cannot be reliably diagnosed via patch testing with today's knowledge. Weak penetration and slow haptenization of pigments, unavailability of pigments as test allergens and a lack of knowledge concerning relevant epitopes hamper the diagnosis of tattoo allergy. Patch testing p‐phenylenediamine and disperse (textile) dyes is not able to close this gap. Sensitization to metals was associated with all types of tattoo complications, although often not clinically relevant for the tattoo reaction. Binders and industrial biocides are frequently missing on ink declarations and should be patch tested. The pigment carbon black (C.I. 77266) is no skin sensitizer. Patch tests with culprit inks were usually positive with cheap ink products for non‐professional use or with professionally used inks in patients with eczematous reactions characterized by papules and infiltration. Tape stripping before patch testing and patch test readings on Day 8 or 10 may improve the diagnostic quality. The meaningfulness of the categorical EU‐wide ban of Pigment Green 7 and Pigment Blue 15:3 is not substantiated by the presented data.
Time for optimism in amyotrophic lateral sclerosis
Authors: Corcia Philippe , Lunetta Christian , Vourc'h Patrick , Pradat Pierre‐François , Blasco Hélène 
Published: February 2023

AbstractBackground and purposeAmyotrophic lateral sclerosis (ALS) is among the most common motor neuron diseases in adults. Nevertheless, ALS remains fatal, despite decades of research and clinical trials, which has led to negative conclusions until recently in regard to four specific treatments. It is well known that we can learn from failures, and we consider that the time has come to present positive insight on this disease.MethodsWe did a literature search using PubMed and Scopus for articles published in English from 1 January 2016, to 30 June 2022 dealing with “amyotrophic lateral sclerosis”, diagnosis, treatment, and biomarkers.ResultsA comprehensive review of the literature on diagnosis, monitoring, and treatment of this condition showed convincing evidence that we are now able to diagnose earlier as well as to better monitor and treat ALS.ConclusionsAlthough ALS is often difficult to diagnose and remains incurable, there are many indications that an optimistic view of ALS management in the coming years is now realistic.
Role of selective attention in fatigue in neurological disorders
Authors: Kuppuswamy Annapoorna 
Published: February 2023

AbstractBackgroundChronic fatigue is a significant symptom in several diseases including traumatic and degenerative neurological disorders. While several studies have investigated the correlates of chronic fatigue, there is as yet no unifying framework to explain chronic fatigue.MethodsIn this narrative review, I investigate the role of selective attention in the development of chronic fatigue and discuss results within the framework of the sensory attenuation model of fatigue, which posits that fatigue is the phenomenological output of altered attention to sensory input. Following a short introduction of this framework, I present results from investigations that address attentional mechanisms in fatigue in multiple sclerosis, stroke, traumatic brain injury and Parkinson's disease.ResultsAttention was quantified in all four disease models using a variety of outcome measures, including behavioural, neurophysiological, structural and functional brain connectivity. The range of measures precluded direct comparison of results across disease conditions; however, in all four disease models there was evidence of poor selective attention that explained levels of chronic fatigue, supporting the sensory attenuation model of fatigue as a disease‐independent mechanism of fatigue. Evidence was lacking to draw any conclusions about the direction of causality.ConclusionThe role of selective attention in development of fatigue is indicated. Future studies must focus on establishing causality and exploring attentional circuitry as a potential therapeutic target.
Seizure forecasting: Where do we stand?
Authors: Andrzejak Ralph G. , Zaveri Hitten P. , Schulze‐Bonhage Andreas , Leguia Marc G. , Stacey William C. , Richardson Mark P. , Kuhlmann Levin , Lehnertz Klaus 
Published: February 2023

AbstractA lot of mileage has been made recently on the long and winding road toward seizure forecasting. Here we briefly review some selected milestones passed along the way, which were discussed at the International Conference for Technology and Analysis of Seizures—ICTALS 2022—convened at the University of Bern, Switzerland. Major impetus was gained recently from wearable and implantable devices that record not only electroencephalography, but also data on motor behavior, acoustic signals, and various signals of the autonomic nervous system. This multimodal monitoring can be performed for ultralong timescales covering months or years. Accordingly, features and metrics extracted from these data now assess seizure dynamics with a greater degree of completeness. Most prominently, this has allowed the confirmation of the long‐suspected cyclical nature of interictal epileptiform activity, seizure risk, and seizures. The timescales cover daily, multi‐day, and yearly cycles. Progress has also been fueled by approaches originating from the interdisciplinary field of network science. Considering epilepsy as a large‐scale network disorder yielded novel perspectives on the pre‐ictal dynamics of the evolving epileptic brain. In addition to discrete predictions that a seizure will take place in a specified prediction horizon, the community broadened the scope to probabilistic forecasts of a seizure risk evolving continuously in time. This shift of gears triggered the incorporation of additional metrics to quantify the performance of forecasting algorithms, which should be compared to the chance performance of constrained stochastic null models. An imminent task of utmost importance is to find optimal ways to communicate the output of seizure‐forecasting algorithms to patients, caretakers, and clinicians, so that they can have socioeconomic impact and improve patients' well‐being.
Current management of generalized pustular psoriasis
Authors: Kodali Nilesh , Blanchard Isabella , Kunamneni Sruthi , Lebwohl Mark G. 
Published: February 2023

AbstractGeneralized pustular psoriasis (GPP) is a rare subset of psoriasis involving episodes of sterile pustules accompanied by inflammation and, often, systemic involvement. The inflammatory nature of GPP has potential for severe multisystem complications including high‐output cardiac failure, infections, digestive system issues, and disfiguring or lethal acute flare episodes. The disease tends to have higher prevalence in females and Asians. The IL‐1/IL‐36 inflammatory pathway is a critical facet of GPP's pathology. Genetic mutations that are associated with GPP include modifications of Interleukin 36 Receptor Antagonist (IL36RN), Caspase Recruitment Domain Family Member 14 (CARD14), Adaptor Related Protein Complex 1 Subunit Sigma 3 (AP1S3), Myeloperoxidase (MPO) and Serpin Peptidase Inhibitor Clade A Member 3 (SERPINA3) genes. Treatment guidelines for GPP are not well‐entrenched. Currently, only one GPP‐specific treatment, the interleukin‐36 receptor antagonist (IL‐36Ra) spesolimab, has been approved for use in the United States. Additional anti‐IL‐36 pathway therapies are currently being developed. Other treatment options include other biologic therapies such as IL‐17 inhibitors, IL‐23 inhibitors and TNFα inhibitors. Non‐biologic therapeutic options include retinoids, cyclosporine and methotrexate. Treatment options differ throughout the world; most countries utilize retinoids, cyclosporine and methotrexate as first‐line non‐biologic options. China and United Kingdom have no GPP‐specific biologic therapies approved for use, while several biologic therapies are approved for use in Japan. This review aims to serve as an update on the current global management of GPP while also including relevant aspects of disease pathogenesis, diagnosis, clinical presentation, histopathology, aetiology and epidemiology.
Gastrointestinal and hepatic manifestations in patients with generalised pustular psoriasis
Authors: Lim Li Yan , Oon Hazel H. 
Published: February 2023

AbstractGeneralised pustular psoriasis (GPP) is a rare and severe form of pustular psoriasis. It is defined by persisting or relapsing macroscopically visible sterile primary pustules occurring on non‐acral skin and not within psoriasis plaques. Due to its rarity, there is a lack of randomised controlled trials on GPP and its associated gastrointestinal (GI) and liver disorders. In this article, we present a review of the GI and hepatic disorders associated with GPP. GPP is known to be associated with extracutaneous manifestations such as neutrophilic cholangitis. Abnormal liver function tests are reported in up to 90% of patients with GPP upon diagnosis. Less commonly, pancreatitis and gastrointestinal bleeding have been attributed to GPP. While a psoriasis registry with 7.5% prevalence of pustular psoriasis reported an association with viral hepatitis B and C, the true relationship remains to be elucidated as hepatitis B is endemic in Asia where GPP prevalence is higher. Common genetic mutations between GPP and conditions such as hepatocellular carcinoma and inflammatory bowel disease have been identified, explaining their possible associations and providing answers to potential therapeutic options for these conditions. A lack of recognition of these association may result in unnecessary withdrawal of efficacious and definitive drugs for the treatment of GPP. Understanding the characteristics of the associated GI and hepatic disorders will have important implications for targeting the appropriate therapeutics.
DNA starvation/stationary phase protection protein of Helicobacter pylori as a potential immunodominant antigen for infection detection
Authors: Zhai Kangle , Gong Yanan , Sun Lu , He Lihua , Xue Zhijing , Yang Yaming , Fang Mengyang , Zhang Jianzhong 
Published: February 2023

AbstractBackgroundApplication of chicken egg yolk immunoglobulin Y (IgY) for Helicobacter pylori (H. pylori, HP) has gained much interest in recent years. Comparing with for treatment, IgY may be more advantageous when used for H. pylori detection.MethodsNine strains of H. pylori with different genetic backgrounds were inactivated and used to immunize hens, respectively, for the preparation of polyclonal anti‐H. pylori immunoglobulin Y (anti‐HP IgY). The proteins of H. pylori with reactivity to anti‐HP IgY were detected by Western Blot. The five protein bands that can be well recognized by anti‐HP IgY of each group, and were prevalent in all nine strains were excised from SDS‐PAGE gel, digested and identified by Nano‐HPLC‐MS/MS analysis. The potential of these identified proteins as antigen detection targets was then assessed by sequence analysis.ResultsAnti‐HP IgY derived from each group of specific strain immunized hens can recognize self‐strain and non‐self‐strain antigens well. Five immunodominant antigens were identified as chaperonin GroEL, flagellin A, urease subunit alpha, peroxiredoxin and DNA starvation/stationary phase protection protein. Sequences analysis showed that both peroxiredoxin and DNA starvation/stationary phase protection protein were present in all 1000 strains of H. pylori queried, and the amino acid sequences were highly conserved. The highest sequence consistency between the DNA starvation/stationary phase protection protein of H. pylori and non‐Helicobacter organisms was 52.59%, and the consistent sites were scattered and there was no continuous long fragment consensus sequence.ConclusionDNA starvation/stationary phase protection protein was identified as an immunodominant antigen of H. pylori and sequence analysis indicated that it could serve as a potential antigen target for the diagnosis of H. pylori infection.
Land‐use change in the Amazon decreases ant diversity but increases ant‐mediated predation
Authors: Wilker Icaro , Lasmar Chaim José , Schmidt Fernando Augusto , da Costa Marília Maria Silva , Almeida Daniely da Frota , Dutra Dhâmyla Bruna de Souza , Alves Adriana de Lima , da Silva Lucas Lima , Ribas Carla Rodrigues 
Published: February 2023

AbstractFood production in Amazonian traditional societies often occurs through shifting cultivation that uses few pesticides and relies on ecosystem services provided by natural enemies. However, these sustainable agricultural practices are being threatened by increasing livestock and mechanised agriculture.This study aimed to evaluate the effects of the conversion from Amazon Forest to anthropogenic land uses (shifting cultivation and pasture) on α‐ and β‐diversity, functional groups, and ant‐mediated predation.Three types of habitats were sampled: forest (eight sites), shifting cultivation (five sites) and pasture (seven sites). The ant assembly of each site was sampled using pitfall traps in the epigeic and hypogeic strata. Beetle larvae were used to evaluate the predation function.Negative effects on epigeic ants and functional groups were found to be greater in sites where anthropogenic land use was more intensive (pasture) than in those where it was less intensive (shifting cultivation). Furthermore, this change increased the predation of insects in shifting cultivation and pasture compared to that in forest. This increase in insect predation was due to high activity ofEctatomma brunneumSmith, 1858, an environmental indicator for shifting cultivation and pasture.The increase in the number of predations in shifting cultivation and pasture may be beneficial from the perspective of biological pest control. However, this relationship needs to be better understood because the high presence and predatory activity ofEctatomma brunneumin these environments may be one mechanism by which α‐ and β‐diversity decrease through antagonistic interactions and dominance.
A review of how pressures and their sources drive sustainable supply chain management practices
Authors: Marculetiu Alina , Ataseven Cigdem , Mackelprang Alan W. 
Published: February 2023

AbstractRapidly growing interest in sustainability coupled with individuals, firms, and other organizations becoming more inclined to agitate for changes internally, and with outside organizations, has resulted in firms being pressured by various sources to change their sustainable supply chain management practices. In this literature review, we synthesize 93 published research articles spanning from 1997 to 2022. We identify and evaluate how pressure types (e.g., coercive, normative, and relational) are used by pressure sources (e.g., governments, suppliers, customers, and employees) to impact firm and sustainable supply chain practices (e.g., internal, upstream, and downstream). Our goal is twofold. First, we aim to guide potential sources as to which types of pressures are most effective in eliciting changes in firm and sustainable supply chain practices. Additionally, we provide insights into not only which relationships have and have not been adequately examined in extant research, but also what could be the next evolution of inquiry in this domain.