bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pleiotropic immunomodulating effects of peptide Arginyl-alpha-Aspartyl-Lysyl-Valyl-Tyrosyl-Arginine on various subsets of neutrophilic granulocytes and their phenotype in patients with COVID-19 <i>in vitro</i>
Authors: Gorodin V. N. , Matushkina V. A. , Chapurina V. N. , Menyailo A. I. , Kovaleva S. V. , Dydyshko E. I. 
Published: June 2023

The key role of neutrophilic granulocytes (NG) in the pathogenesis of COVID-19 makes them new targets for therapeutic approaches and of influencing the course and outcome of the disease, restoring changes in the phenotype and functions of NG. Synthetic peptides or polypeptide complexes of action are the most promising in the treatment of COVID-19. Aim: to reveal the effects of the influence of the hexapeptide (HP) – Arginyl-alpha-Aspartyl-Lysyl-Valyl-Tyrosyl-Arginine on the phenotype of functionally significant NG subsets in moderate COVID-19.The study examined patients 61 (57-71) years old (n = 45) in the acute period of COVID-19 – study group1 (SG1). In vitro, samples SG1 were incubated with HP (106 g/L, 60 min, 37 °C) – study group2 (SG2). The number of NG subsets was evaluated: CD16+IFNα/βR1+CD119+, CD16+IFNα/βR1+CD119- , CD16+IFNα/βR1+CD119+, CD64- CD16+CD32+CD11b+, CD64+CD16+CD32+CD11b+ and phenotype by membrane receptor expression density (MFI) (FC 500, Beckman Coulter, USA); NG phagocytic activity was tested before and after incubation with HP. The comparison group (GS) – of 22 volunteers examined in the pre-COVID period.It was revealed that unidirectional effects of HP in vitro contributing to the restoration of the phenotype of subsets CD16+IFNα/βR1- CD119+, CD16+IFNα/βR1+CD119- to CG indicators. There was a decrease in MFI CD16 (p < 0.05) in both subsets; MFI CD119 (p < 0.05) in the CD16+IFNα/βR1- CD119+NG subset, MFI IFNa/βR1 in the CD16+IFNα/βR1+CD119- NG subset. The effects of HP on the phenotype of CD16+IFNα/βR1+CD119+NG subsets in 76% of cases were manifested by a decrease in MFI CD16 (p<0.05), an increase in MFI IFNα/βR1 and CD119 (p1, 2<0.05), and in 24% of cases a decrease in MFI IFNα/βR1 (p<0.05). HP in vitro remodeling of the phenotypes subsets CD64- CD16+CD32+CD11b+ and CD64+CD16+CD32+CD11b+ were established, providing the usefulness of effector functions from hyperactivated to normal. In the CD64- CD16+CD32+CD11b+ subset, there was a decrease in MFI CD16 and CD11b to the indicators CG (p1, 2 < 0.05). Recovery of the NG phenotype under the influence of HP led to the restoration of the phagocytic function of NG.Positive effects of HP in vitro on the phenotypes of subsets actively and NGfunctions in COVID-19 open up prospects for the creation of new methods of immunotherapy to restore NG dysfunctions.
Automatisierungsdienste-Choreografien in der Prozessindustrie
Authors: Stutz Andreas , Mathias Mathias , Eckert Manfred , Barth Mike , Blumenstein Michelle , Fay Alexander 
Published: June 2023

Die Modularisierung von Produktionssystemen im Labor, im Technikum und in der Produktion nimmt stetig zu. Immer feingranularere Dienste-Strukturen erfordern neuartige Mechanismen zur Zusammenführung eben dieser feingranularen Funktionen. Da Orchestrierungslösungen hier an Grenzen stoßen, wird in diesem Beitrag die Anwendung von Automatisierungsdienste-Choreografien anhand zweier praxisrelevanter Anwendungsszenarien in der modularen Produktion vorgestellt und mittels einer modularen Laboranlage evaluiert. Im Ergebnis zeigt sich, dass Choreografien für diese Art der Zusammenführung geeignet sind.
The Role of Digital Platforms in the Organization of the Financial Market
Authors: Sitnik A. A. 
Published: June 2023

The paper aims to determine the role of digital platforms in the organization of the financial market on the basis of a critical analysis of existing regulatory legal acts, scientific papers and practices on the said market. To achieve the stated goal, the following tasks were set: to determine the content of such concepts as «digital platform» and «digital financial platform»; to identify the types of digital platforms; to classify digital financial platforms; to identify the impact of the introduction of digital platforms in the activities of financial organizations on public relations emerging in the financial market.It is established that the digital platform can be viewed from various points of view: as an information system, a digital environment, a combination of digital tools and services, a hosting service provider, a set of rules according to which participants interact.It is noted that digitalization in general and the introduction of digital platforms in particular lead to changes in the structure of the financial market, business models of financial organizations, the order of interaction between financial service providers and their customers, the behavior of consumers of financial services, as well as to a number of other fundamental shifts affecting the financial market.In the course of the study, digital financial platforms and financial platforms in the proper sense of the word are differentiated (the functioning of which is regulated by the norms of Federal Law № 211‑FZ dated 20.07.2020 «On Financial transactions using a financial platform»).The classification of digital financial platforms is carried out on various grounds: depending on the type of services provided with their help (basic digital financial platforms, infrastructure digital financial platforms, service (optional) digital financial platforms), by the nature of the financial services provided (independent digital financial platforms, intermediary digital financial platforms, mixed), by functional purpose as part of the activities of the financial market regulator (RegTech and SupTech platforms).
Aspek Keadilan Pengaturan Pemberian Ganti Rugi dalam Pengadaan Tanah untuk Pembangunan bagi Kepentingan Umum
Authors: Adhisukmawati I Gusti Ayu Kade Harry , Handayani I Gusti Ayu Ketut Rachmi , Karjoko Lego 
Published: June 2023

The demand for land in the context of public-interest development is growing, but the supply of land is limited. Fairness and compensation mechanisms are usually challenging in the purchase of property for public use. The goal of this research is to look at the rule's fairness elements as well as the method for awarding compensation in the purchase of property for public development. This study is normative and prescriptive, with a regulatory and conceptual approach. The study's findings revealed that a) the fairness aspect in the regulation of land acquisition for development in the public interest must provide a guarantee of proper replacement, as stipulated in Law Number 2 of 2012 concerning Land Acquisition for Development in the Public Interest, Law Number 11 of 2020 concerning Job Creation, Indonesian Assessment Standard 204, and other land acquisition laws and regulations. And b) the compensation mechanism is implemented when the assessment is finished by the Indonesian Assessment Standard 204, Law Number 11 of 2020 about Job Creation, discussions, and validation activities. The payment can be made in Rupiah, as agreed upon by the Land Acquisition Committee and the community, and then transferred to a bank account designated by the government.
Keywords: Indemnity; Land Acquisition; Public Interest Development
A case of outdoor education for SMEs during the COVID-19 pandemic: The mediating role of entry mode
Authors: Jannah Nurjannah Nur , Angreyani Andi Dewi , Musakirawati Musakirawati , Supri Baharman , Marwan Marwan 
Published: June 2023

The international expansion process of firms has been the subject of many studies, nonetheless only Western firms have become the most discussed within the literature. Fewer studies have been done with an emphasis on Southeast Asian firms. Following this issue, this study aims to investigate the most suitable strategy as well as the best entrance modes for firms to internationalize and accordingly, to offer a strategy implementation guideline for firms to enter foreign markets successfully. As the research method prerequisite, this study applies the quantitative approach. The key finding of this study indicates that there is a strong positive relationship between firms’ international expansion and foreign market entrance. Additionally, this study’s finding is also considered a useful guideline for the SME manager to internationalize or enter the foreign market, especially during the hits of the COVID-19 Pandemic.
Keywords: COVID-19; entry mode; international expansion; outdoor education; SMEs.
Alonso Pino Ávila, La autonomía reproductiva en la jurisprudencia del Tribunal Europeo de Derechos Humanos
Authors: Márquez de Haro Mireia 
Published: June 2023

Este artículo reseña: Alonso PINO ÁVILA, La autonomía reproductiva en la jurisprudencia del Tribunal Europeo de Derechos Humanos, Aranzadi, Pamplona 2023, 310 pp.
MODELING AND ANALYZING THE EFFECT OF CONNECTION TO THE NETWORK OF A HARMONIC SOURCE HAVING VARIOUS TOTAL HARMONIC DISTORTION FACTORS ON LOAD SIGNAL WAVEFORMS
Authors: Peretyatko J.V. , Trotsenko Y.O , Polishchuk N.O. 
Published: June 2023

This article examines the effect of a network connected source of harmonics having a total harmonic distortion factor varying from 5% to 15% on load voltage and current waveforms. When a source of higher harmonics is connected to the network, both in the network and in the load, the effective values of voltage and current increase, that can negatively affect the cable line insulation, accelerating its destruction and aging.
To analyze the consequences of a power quality deterioration, a 20 kV network was simulated, consisting of a 20 kV symmetrical generator, an XRUHAKXS-20(1x120/50) power cable line 20 km long, a step-down transformer 20/0.4 kV with a power of 2 MVA, with windings connected in delta-star, and a three-phase symmetrical load.
The values of the currents flowing through the cable conductor, obtained as the result of simulation were used to calculate the voltage drop between the cable conductor and its shield. Results obtained show that the connection of a harmonic distortion source to a network leads to a magnification of a current flowing through the cable conductor by more than 2%. The model proposed in the article can be used further for a more detailed study of solar photovoltaic plants connection to the grid.
One of the biggest problems regarding solar power plants is that its electricity generation is intermittent. Thus, future efforts should be focused on modeling and studying the higher harmonics generation during switching on and off of the solar photovoltaic plants.
COMPRESSING AIR IN A TANK PARTIALLY FILLED FROZEN WATER AND ITS USE TO DRAIN WATER FROM SOLAR COLLECTORS
Authors: Pukhovyi I. , Nazarova I. 
Published: June 2023

The use of the effect of increasing the volume of ice when freezing water to compress the air in a tank partially filled with water is considered. The aim of the study is to create conditions for the movement of the ice surface and determine the final air pressure after freezing water. A method of air compression has been developed and theoretical and experimental studies of the final air pressure have been performed. Experimental tests of a patented method of air compression with the provision of a movable ice surface by applying thermal insulation to the air chamber at the top of the tank were carried out. For this purpose, two air compressors of different sizes are made using cold air and a mixture of ice and salt. Obtained excess air pressures from 0.3 to 0.5 bar. The thermodynamic analysis of the process is carried out. The equation for determining the pressure at complete freezing of water, with a constant cross-section of the air compressor is obtained. Compression calculations are close to experimental data. Studies have shown the real technical possibility of air compression when water freezes in a rigid sealed tank and its use for automatic drainage of water from solar panels at the onset of frost. 1. The proposed and experimentally investigated method of ensuring the movement of the ice surface relative to the walls of the tank when compression of the air in the tank, by thermal insulation of the airspace. Obtained thermodynamic analysis of the equation for the final pressure of the air compressed by ice. When using a tank with a constant horizontal section, the final pressure does not depend on the area of ​​the cross section and increases with increasing water level. The experiments on two installations showed that excess pressure reaches 0.3 - 0.5 bar. Freezing water tank is proposed to be used as a temperature sensor, and compressed air can drive a direct action valve. Calculations of water freezing time for compression of the air showed its significant reduction with the growth of the tank coefficient.
IMPLEMENTATION OF 20 kV VOLTAGE NETWORK IN UKRAINE
Authors: Iskova M. S. , Buriak A. R. , Kyryk V. V. 
Published: June 2023

Background Due to the war, the medium voltage networks are in an extremely difficult condition, they have a high degree of depreciation of electrical equipment and a low level of automation. The energy system of Ukraine has a problem of modernizing medium voltage networks and transfer them to a new class of rated voltage of 20 kV.
Objective Overall overview of 20 kV networks and organization of their topology with renewable energy sources and " energy storages ".
Methods A network model in the MatLab software package was used to study "energy accumulators". The study of the efficiency of the "energy storages" was carried out in the variability of the power to the total load, as well as the time of connection to the network.
Results The need to transfer voltages of 6 (10) kV to a higher level of 20 kV has been proven. Various methods of grounding the neutral of medium voltage networks are considered and the most effective modes of neutral grounding for 20 kV networks are determined: through an arc suppression coil or through a resistor. A comparative analysis of networks with and without energy storage was carried out. In 20 kV networks, without the use of energy storage, energy consumption from the network and power losses will increase. When using storage devices, they are permanently connected to the network and have their own power losses. Batteries connected to a 20 kV network lead to an oscillating process that has a damping character (within 2 seconds).
Conclusions The transition from the voltage level of 6 (10) kV to 20 kV will significantly increase the efficiency of distribution networks and reduce electricity losses. The installation of energy storage in 20 kV distribution networks will allow the introduction of new intelligent systems to ensure the interests of safety, economy and energy efficiency and will create the prerequisites for the implementation of the Smart Grid concept.
IN VITRO WOUND HEALING ACTIVITY OF SAPIUM INDICUM WILLD LEAF EXTRACTS
Authors: Azis Huwaida Abdul , Taher Muhammad , Susanti Deny , Zakaria Zainul Amiruddin 
Published: June 2023

Background: Sapium indicum Willd (Euphorbiaceae) is traditionally used to accelerate wound healing process in Malay community.
Objective: To evaluate wound healing potential of aqueous (AESI) and ethanolic extract of S. indicum leaves (EESI) using cell migration model.
Methods: AESI and EESI were prepared using maceration techniques. The extracts were subjected to phytochemical screening, cytotoxicity (MTT assay) and scratch assay.
Results: AESI contained saponins and tannins while EESI contained triterpenes, tannins and proteins. Based on MTT assay, AESI and EESI exhibited IC50 = 16.3 and 70.9 µg/mL, respectively. In the scratch assay, EESI caused significant (P< 0.05) concentration-dependent migration on 3T3 L1 cells whereas AESI exerted concentration-independent effect.
Conclusion: The leaves of S. indicum exhibited wound healing potential and contained phytochemicals that may contribute to the activity. These findings would support potential use of S. indicum as wound healing plant.
HYPOGLYCAEMIC AND HAEMATINIC PROPERTIES OF ETHANOL LEAF EXTRACT OF ARTOCARPUS HETEROPHYLLUS IN ALLOXAN INDUCED DIABETIC RATS.
Authors: C. Okonkwo Christopher , Victor Agu Chidozie , U. Njoku Obioma , Uchenna Abonyi , Victor Apeh , G. Anaduaka Emeka , V Iloabuchi Kenechukwu , E. Odo Christian 
Published: June 2023

Background: Anaemia is known to be associated with diabetes; moreover, with the increasing cases of diabetes there is need for the use of more affordable alternative herbal medicines for the treatment of diabetes and anaemia. The aim of this work was to evaluate the hypoglycaemic and haematinic properties of Artocarpus heteropyllus on diabetic rats.
Materials and Methods: Ethanol leaf extract of Artocarpus heteropyllus was screened for phytochemicals and its acute toxicity was tested on mice. Induction of diabetes was done at a dose of 150 mg/kg body weight (b.w) (with exception of the control group). The extract was administered to rats for a period of 7 days at 100, 300 and 500 mg/kg b.w, respectively, following induction. Blood samples of rats were tested for fasting blood sugar (FBS), packed cell volume (PCV), white blood cell (WBC), red blood cell (RBC), haemoglobin, neutrophil lymphocyte and eosinophil counts.
Results: The ethanol leaf extract of A. heterophyllus showed no mortality up to a dose of 5000 mg/kg b.w. Administration of the extract to diabetic rats resulted in a decrease in the FBS of diabetic rat, and significant increases (p< 0.05) in RBC, PCV, WBC and haemoglobin levels.
Conclusion: The ethanol leaf extract of A. heterophyllus increased the haematological indices of diabetic rats. Our findings support the use of this plant as an herbal alternative in the treatment of diabetes and anaemia associated diabetes.
ANTIBACTERIAL AND ANTIFUNGAL ACTIVITIES OF THE EXTRACT AND FRACTIONS OF AERIAL PARTS OF HELIOTROPIUM BACCIFERUM
Authors: Ullah Riaz , Ahmad Sohail , Bibi Ihteram , AbdEl-SalaSalam Naser M. , Hussain Hidayat , Ishaq Muhammad Saqib , Adnan Muhammad , Tariq Akash , Ullah Riaz 
Published: June 2023

Background: H. bacciferum belonging to the family Boraginaceae is an important medicinal plant. The current research was carried out to investigate the medicinal properties of this plant.
Methodology: The crude (methanol fraction) and n-hexane, ethyl acetate, butanol and aqueous fractions were subjected to antibacterial and antifungal activities by using standard methodology available in literature. Bacterial strains of Salmonella typhi, Escherichia coli, Pseudomonas Aeroginosa, Staphylococcus aureus, Erwinia carotovora, Klebsiella Pneumoniae, Bacillus subtilis and Bacillus atrophaeus were used for antibacterial activity.
Results: All the fractions were active against different bacterial strains but n-hexane and ethyl acetate showed (Zone of inhibition ranged from 18-30 mm) highest activity. The fungal strains, Trichoderma longibrachiantum, Aspergillus flavus, Aspergillus niger, Fusarium solani and Candida albican were used for antifungal activity. Excellent inhibitory effect was observed against all fungal strains. The minimum inhibitory concentration (MIC) against various fungal strains was determined. The minimum inhibitory concentrations (MICs) of the investigated plant fractions ranged from 0.5-2.00 mg/ml.
Conclusion: The plant showed significant antibacterial and antifungal activities. All tested plant extracts exhibit activities against different fungal strains. The result against various microorganisms shows the therapeutic potential of the plant H. bacciferum
INVESTIGATION OF HYPOGYCEMIC AND HYPOLIPIDEMIC EFFECTS OF AN AQUEOUS EXTRACT OF LUPINUS ALBUS LEGUME SEED IN STREPTOZOTOCIN-INDUCED TYPE I DIABETIC RATS.
Authors: Sewani-Rusike Constance Rufaro , Jumbam Denis N. , Chinhoyi Lionel R. , Nkeh-Chungag Benedicta N. 
Published: June 2023

Background: Lupinus albus (LA) seed is a legume food used traditionally for the treatment of diabetes. The aim of this study was to investigate the effects of an aqueous extract of LA on lipid and glucose levels in normal and STZ induced Type 1 diabetic rats.
Methods: Aqueous extract of LA was prepared and used for animal treatments. Diabetes was induced by a single intraperitoneal injection of streptozotocin (60mg/kg body weight). Effects of LA on oral glucose tolerance in normal and diabetic rats were investigated by giving a single dose of distilled water (controls), 200 or 400mg/kg LA extract, metformin 300mg/kg or glibenclamide 500µg/kg after 12 hours of fasting (time 0 glucose). After 15 minutes, a glucose load (3g/kg) was given. Glucose levels were measured at 30, 60, and 120 minutes after glucose loading. To investigate long term effects, animals were given similar treatments daily for 4 weeks. At the end of the study, serum glucose, insulin, total cholesterol (TC), triglycerides (TG), low density lipoprotein (LDL-C), very low density lipoprotein (VLDL-C) and high density lipoprotein (HDL-C) cholesterol levels were measured or calculated.
Results: LA demonstrated significant (P
ANTIOXIDANT AND ANTIBACTERIAL ACTIVITIES OF DIFFERENT PLANTS EXTRACTS AGAINST STAPHYLOCOCCUS AUREUS ISOLATED FROM SOCCER PLAYER’S SHOES AND KNOWLEDGE AND APPLICATIONS ABOUT FOOT HYGIENE OF THE SOCCER PLAYERS
Authors: Okmen Ahmet Sadan 
Published: June 2023

Background: The microorganisms most commonly attacks the feet. Bacteria have an easier entry into the athlete’s epidermis. Staphylococcus aureus, commonly found on the skin or in the nose. The purpose of the study is to search the lack of knowledge about the antibacterial and antioxidant effects of different plants extracts and to search the knowledge about hygiene and hygiene of sports equipment of soccer players.
Materials and Methods: The bacteria were isolated from soccer player’s shoes (n=28) from Balıkesir Spor soccer team after the competition. Additionally, ten plants were collected from Mugla, Hatay, and Hakkari in Turkey. In antibacterial activity studies, the plant materials were tested by disc diffusion assay. Furthermore, the different plants extracts were studied by ABTS decolorization assay.
Results: The highest antibacterial activity was shown on S. aureus- BFT2 (22 mm) for Hypericum perforatum L. subsp. veranese (Schrant) H. Lindb. The different extracts possessed antibacterial activity, and showed MIC effect at 812.5 µg/mL. The antioxidant activities by ABTS assay were in the order of Arbutus andrachne (flower) > Arbutus andrachne (leaf) > Anthemis sp. (flower) > Crepis sancta L. (leaf) > Allium sphaerocephalon (root) > Plantango major (leaf) > Lavandula steochas (flower) > Anthemis sp. (flower) > Urtica dioica (leaf) > Lavandula steochas (leaf) > Anthemis sp. (leaf) > Hypericum perforatum L. subsp. veranese (Schrant) H. Lindb (flower) > Anthemis chia L. (leaf).
Conclusion: Different plant extracts have antimicrobial, antioxidant and potential.