bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Impact of Bicuspid Aortic Valve Leaflet Fusion Morphology on the Ascending Aorta and on Outcomes of Aortic Valve Replacement
Authors: Bibevski Steve , Ruzmetov Mark , Plate Juan F. , Scholl Frank G. 
Published: March 2023

Background
Patients with bicuspid aortic valves (BAVs) tend to develop dilation of the ascending aorta. The aim of this study was to analyze the impact of leaflet fusion pattern on aortic root diameter and outcomes in patients undergoing surgery for BAV vs tricuspid aortic valve (TAV) disease.

Methods
This is a retrospective review of 90 patients with aortic valve disease (mean [SD] age, 51.5 [8.2] years) who underwent aortic valve replacement for BAV (n = 60) and TAV (n = 30). Fusion of right-left (R/L) coronary cusps was identified in 45 patients, whereas the remaining 15 patients had right-noncoronary (R/N) cusp fusion. Aortic diameter was measured at 4 levels, and Z values were computed.

Results
There were no significant differences between the BAV and TAV groups for age, weight, aortic insufficiency grade, or size of implanted prostheses. However, a higher preoperative peak gradient at the aortic valve was significantly associated with R/L fusion (P = .02). Preoperative Z values of ascending aorta and sinotubular junction diameter were significantly higher in patients with R/N fusion than with the R/L (P < .001 and P = .04, respectively) and TAV (P < .001 and P < .05, respectively) subgroups. During the follow-up period (mean [SD], 2.7 [1.8] years), 3 patients underwent a redo procedure. At the last follow-up, the sizes of ascending aorta were similar among all 3 patient groups.

Conclusion
This study suggests that preoperative dilation of the ascending aorta is more common in patients with R/N fusion than in patients with R/L and TAV but is not significantly different between all groups in the early follow-up period. R/L fusion was associated with an increased risk of preoperative presence of aortic stenosis.
”Sveriges första barnbok med hen”
Authors: Almqvist Louise 
Published: March 2023

”Sweden’s First Children’s Book with They”: Norm-Criticism and Didactics in Kivi & Monsterhund
Around 2007, several self-proclaimed norm-critical publishing companies were established in Sweden. This caused a long debate in the daily press, where some critics compared the ”norm-critical” books to propaganda. The debate indicates a conflict between an aesthetic and a didactic approach to children’s literature. Another lively debate with similar critique took off when Kivi & Monsterhund (Kivi and Monsterdog, 2012) by Jesper Lundqvist and Bettina Johansson was published – a picturebook where the protagonist is referred to by a gender-neutral prounoun. The purpose of this article is to problematise the prevailing view on self-proclaimed norm-critical children’s literature and its didactic relationship to the reader. The reception, the paratexts, and the book itself are analysed using Torben Weinreich’s and Clémentine Beauvais’ different definitions of didactics, Gérard Genette’s view on pararatexts, Maria Nikolajeva’s theories on picturebooks, and Judith Butler’s view on gender as performative. The book, and its didactic relationship to the reader, is found to be much more complex and conflicting than suggested by the reception and the paratexts.
Visualization of cardiac uptake of bone marrow mesenchymal stem cell‐derived extracellular vesicles after intramyocardial or intravenous injection in murine myocardial infarction
Authors: Xu Cynthia M. , Sabe Sharif A. , Brinck‐Teixeira Rayane , Sabra Mohamed , Sellke Frank W. , Abid M. Ruhul 
Published: March 2023

AbstractIn animal models, human bone marrow mesenchymal stem cell‐derived extracellular vesicles (MSC‐EV) have been found to have beneficial effects in cardiovascular disease, but only when administered via intramyocardial injection. The biodistribution of either intravenous or intramyocardial injection of MSC‐EV in the presence of myocardial injury is uncharacterized at this time. We hypothesized that intramyocardial injection will ensure delivery of MSC‐EV to the ischemic myocardium, while intravenous injection will not. Human bone marrow mesenchymal stem cells were cultured and the MSC‐EV were isolated and characterized. The MSC‐EVs were then labeled with DiD lipid dye. FVB mice with normal cardiac function underwent left coronary artery ligation followed by either peri‐infarct intramyocardial or tail vein injection of 3*106 or 2*109 particles of DiD‐labeled MSC‐EV or a DiD‐saline control. The heart, lungs, liver, spleen and kidneys were harvested 2 h post‐injection and were submitted for fluorescent molecular tomography imaging. Myocardial uptake of MSC‐EV was only visualized after intramyocardial injection of 2*109 MSC‐EV particles (p = 0.01) compared to control, and there were no differences in cardiac fluorescence after tail vein injection of MSC‐EV (p = 0.5). There was no significantly detectable MSC‐EV uptake in other organs after intramyocardial injection. After tail vein injection of 2*109 particles of MSC‐EV, the liver (p = 0.02) and spleen (p = 0.04) appeared to have diffuse MSC‐EV uptake compared to controls. Even in the presence of myocardial injury, only intramyocardial but not intravenous administration resulted in detectable levels of MSC‐EV in the ischemic myocardium. This study confirms the role for intramyocardial injection in maximal and effective delivery of MSC‐EV. Our ongoing studies aimed at developing bioengineered MSC‐EV for targeted delivery to the heart may render MSC‐EV clinically applicable for cardiovascular disease.
Performance comparison of three scaling algorithms in NMR-based metabolomics analysis
Authors: Liu Xia , Fang Yiqun , Ma Haifeng , Zhang Naixia , Li Ci 
Published: March 2023

Abstract
Unit variance (UV) scaling, mean centering (CTR) scaling, and Pareto (Par) scaling are three commonly used algorithms in the preprocessing of metabolomics data. Based on our NMR-based metabolomics studies, we found that the clustering identification performances of these three scaling methods were dramatically different as tested by the spectra data of 48 young athletes’ urine samples, spleen tissue (from mice), serum (from mice), and cell (from Staphylococcus aureus) samples. Our data suggested that for the extraction of clustering information, UV scaling could serve as a robust approach for NMR metabolomics data for the identification of clustering analysis even with the existence of technical errors. However, for the purpose of discriminative metabolite identification, UV scaling, CTR scaling, and Par scaling could equally extract discriminative metabolites efficiently based on the coefficient values. Based on the data presented in this study, we propose an optimal working pipeline for the selection of scaling algorithms in NMR-based metabolomics analysis, which has the potential to serve as guidance for junior researchers working in the NMR-based metabolomics research field.
Long-term stability of thyroid peroxidase antibody (anti-TPO) in serum in the Danish General Suburban Population Study
Authors: Jensen Christian Z. , Nygaard Birte , Faber Jens , Pedersen Palle L. , Larsen Morten K. , Kanters Jørgen K. , Poulsen Henrik E. , Kellogg Mark , Ellervik Christina 
Published: March 2023

Abstract

Objectives
We evaluated the long-term stability of thyroid peroxidase antibody (anti-TPO).

Methods
In the Danish General Suburban Population Study (GESUS), serum samples were biobanked at −80 °C during 2010–2013. In a paired design with 70 subjects, we compared anti-TPO (30–198 U/mL) measured on fresh serum on Kryptor Classic in 2010–2011 (anti-TPOfresh) with anti-TPO remeasured on frozen serum (anti-TPOfrozen) on Kryptor Compact Plus in 2022. Both instruments used the same reagents and the anti-TPOn automated immunofluorescent assay, which was calibrated against the international standard NIBSC 66/387, based on the Time Resolved Amplified Cryptate Emission (TRACE) technology from BRAHMS. Values greater than 60 U/mL are regarded as positive in Denmark with this assay. Statistical comparisons included Bland-Altman, Passing-Bablok regression, and Kappa statistic.

Results
The mean follow-up time was 11.9 years (SD: 0.43). For anti-TPOfrozen vs. anti-TPOfresh, the line of equality was within the confidence interval of the absolute mean difference [5.71 (−0.32; 11.7) U/mL] and the average percentage deviation [+2.22% (−3.89%; +8.34%)]. The average percentage deviation of 2.22% did not exceed analytical variability. Passing-Bablok regression revealed both a statistically significant systematic and proportional difference: Anti-TPOfrozen=−22.6 + 1.22*(anti-TPOfresh). Frozen samples were correctly classified as positive in 64/70 (91.4%; Kappa=71.8%).

Conclusions
Anti-TPO serum samples in the range 30–198 U/mL were stable after 12-years of storage at −80 °C with an estimated nonsignificant average percentage deviation of +2.22%. This comparison is based on Kryptor Classic and Kryptor Compact Plus, which used identical assays, reagents, and calibrator, but for which the agreement in the range 30–198 U/mL is unclarified.
Holomorphic polylogarithms and Bloch complexes
Authors: Zickert Christian K. 
Published: March 2023

Abstract
For an integer

n
≥
2

{n\geq 2}

we define a polylogarithm

ℒ
^

n

{\widehat{\mathcal{L}}_{n}}

, which is a holomorphic function on the universal abelian cover of

ℂ
∖

{
0
,
1
}

{\mathbb{C}\setminus\{0,1\}}

defined modulo

(

2
⁢
π
⁢
i

)

n

/

(

n
-
1

)

!

{(2\pi i)^{n}/(n-1)!}

.
We use the formal properties of its functional relations to define groups

ℬ
^

k

⁢

(

F
^

)

{\widehat{\mathcal{B}}_{k}(\widehat{F})}

lifting Goncharov’s Bloch groups

ℬ
k

⁢

(
F
)

{\mathcal{B}_{k}(F)}

of a field F, and show that they fit into a complex

Γ
^

⁢

(
F
,
n
)

{\widehat{\Gamma}(F,n)}

lifting Goncharov’s Bloch complex

Γ
⁢

(
F
,
n
)

{\Gamma(F,n)}

. When

F
=
ℂ

{F=\mathbb{C}}

, we show that the imaginary part (when n is even) or real part (when n is odd) of

ℒ
^

n

{\widehat{\mathcal{L}}_{n}}

agrees with a real single valued polylogarithm

ℒ
n

{\mathcal{L}_{n}}

on the group

H
1

⁢

(

Γ
^

⁢

(
ℂ
,
n
)

)

{H^{1}(\widehat{\Gamma}(\mathbb{C},n))}

. When

n
=
2

{n=2}

, this group is Neumann’s extended Bloch group. Goncharov’s complex conjecturally computes the rational motivic cohomology of F, and one may speculate whether the extended complex computes the integral motivic cohomology. Finally, we use

ℒ
^

3

{\widehat{\mathcal{L}}_{3}}

to construct a lift of Goncharov’s map

H
5

⁢

(

SL
⁡

(
3
,
ℂ
)

)

→
ℝ

{H_{5}(\operatorname{SL}(3,\mathbb{C}))\to\mathbb{R}}

to a complex valued map whose real part agrees with that of Goncharov. The lift makes use of the cluster ensemble structure on the Grassmannian

Gr
⁡

(
3
,
6
)

{\operatorname{Gr}(3,6)}

.
On superintegral Kleinian sphere packings, bugs, and arithmetic groups
Authors: Kapovich Michael , Kontorovich Alex 
Published: March 2023

Abstract
We develop the notion of a Kleinian Sphere Packing, a generalization of
“crystallographic” (Apollonian-like) sphere packings defined in [A. Kontorovich and K. Nakamura,
Geometry and arithmetic of crystallographic sphere packings,
Proc. Natl. Acad. Sci. USA 116 2019, 2, 436–441].
Unlike crystallographic packings, Kleinian packings exist in all dimensions, as do “superintegral” such.
We extend the Arithmeticity Theorem to Kleinian packings, that is, the superintegral ones come from

ℚ

{{\mathbb{Q}}}

-arithmetic lattices of simplest type.
The same holds for more general objects we call Kleinian Bugs, in which the spheres need not be disjoint but can meet with dihedral angles

π
m

{\frac{\pi}{m}}

for finitely many m.
We settle two questions from Kontorovich and Nakamura (2019): (i) that the Arithmeticity Theorem is in general false over number fields, and (ii)
that integral packings only arise from non-uniform lattices.
A case of preeclampsia with severe features following septic shock and drug-induced acute kidney injury
Authors: Boyd Emily M. , Nguyen Michelle T. , Gordon Brian , Lee Richard H. 
Published: March 2023

Abstract

Objectives
This article outlines a process for differentiating preeclampsia from other potential causes of end-organ damage in a critically ill patient.

Case Presentation
A patient in her early 30s, G2P1001 with intrauterine pregnancy at 12 weeks’ gestation was admitted seven months after delivering her first child due to new-onset psychosis and starvation ketosis. She was started on lithium for postpartum psychosis at 20 weeks’ gestation. She subsequently developed respiratory failure at 26 weeks’ gestation due to aspiration pneumonia in the setting of lithium toxicity, requiring admission to the intensive care unit (ICU) and intubation. She received antibiotics and vasopressors for suspected septic shock in addition to dialysis for lithium-induced acute kidney injury. One week after ICU admission, her sepsis resolved, her serum creatinine levels returned to normal, and her respiratory status improved. However, after vasopressors were discontinued, she suddenly developed persistently elevated blood pressures with proteinuria and elevated liver function tests (LFT’s). Due to concern for preeclampsia with severe features and rapidly increasing LFT’s, the patient underwent cesarean delivery at 27 weeks’ gestation.

Conclusions
In a critically ill patient with multiple comorbidities, it can be difficult to diagnose preeclampsia using the standard criteria. It is important to exclude other potential etiologies, as a misdiagnosis can have potentially devastating consequences.
Differential effects of affective arousal and valence on humor appreciation in female university students
Authors: Carretero-Dios Hugo , Delgado-Rico Elena , López-Benítez Raúl , Acosta Alberto 
Published: March 2023

Abstract
The aim of this experimental study was to clarify whether affective states with different arousal and valence levels influence the perceived funniness and aversiveness shown as a response to humor stimuli. We used the International Affective Picture System, IAPS (Lang, Peter J., Margaret M. Bradley & Bruce N. Cuthbert. 1999. International Affective Picture System (IAPS): Technical manual and affective ratings. Gainesville, FL: The Center for Research in Psychophysiology, University of Florida) and followed a mixed factorial design. Affective state differed between four groups: 1) neutral group; 2) negative valence-moderate arousal group; 3) positive valence-moderate arousal group; and 4) negative valence-high arousal group. We measured pre- and post-perceived funniness and aversiveness in response to humorous material. Participants were 80 psychology students who were randomly assigned to one of four induction conditions. The results showed that, regardless of the type of valence, affective states with moderate arousal levels did not affect humor appreciation. However, the perceived funniness response was significantly lower in the negative valence-high arousal group. Perceived aversiveness responses were not affected by valence or arousal level. Results are discussed in relation to several current theories on the role of affective state in humor appreciation.
Master-slave synchronization in the Duffing-van der Pol and Φ6Duffing oscillators
Authors: Uriostegui-Legorreta Ulises , Tututi Eduardo Salvador 
Published: March 2023

AbstractIn this work a master-slave configuration to obtain synchronization between the double-well Duffing-van der Pol (master system) and the three-well Φ6Duffing oscillators (slave system) is studied. For this configuration, we analyze the system when the dissipative and one that combines the elastic and dissipative couplings are used. Whenever the dissipative coupling is used, we observed a vertical shift synchronization in the slave system. However, when the combination of the elastic and dissipative couplings is used, the vertical shift disappears obtaining complete synchronization. We resort to perturbation method to corroborate analytically these kind of synchronization, when the master system provides an harmonic function to the slave system. These synchronizations are numerically corroborated.
Maintenance tocolysis, tocolysis in preterm premature rupture of membranes and in cervical cerclage – a Germany-wide survey on the current practice after dissemination of the German guideline
Authors: Stelzl Patrick , Kehl Sven , Oppelt Peter , Mayr Andreas , Fleckenstein Tobias , Maul Holger , Enengl Sabine , Berger Richard , Rath Werner 
Published: March 2023

Abstract

Objectives
To investigate the adherence of German perinatal specialist units and those of basic obstetric care to the national guideline we compared data from a nation-wide survey on the practice of maintenance tocolysis, tocolysis in preterm premature rupture of membranes and in the perioperative setting of cervical cerclage, and bedrest during and after tocolysis with recommendations from the current German Guideline 015/025 “Prevention and Treatment of Preterm Birth”.

Methods
A total of 632 obstetric clinics in Germany were approached and received a link to an online questionnaire. Data were descriptively analyzed by performing measures of frequency. To compare two or more groups Fisherʼs exact test was used.

Results
The response rate was 19%; 23 (19.2%) of respondents did not perform maintenance tocolysis, while 97 (80.8%) conducted maintenance tocolysis; 30 (25.0%) of obstetric units performed cervical cerclage without tocolysis and 90 (75.0%) combined cervical cerclage with tocolysis; 11 (9.2%) of respondents did not use tocolytics in patients with preterm premature rupture of membranes, while 109 (90.8%) conducted tocolysis in these patients; 69 (57.5%) of obstetric units did not recommend bed rest during tocolysis, whereas 51 (42.5%) favored bedrest. Perinatal care centers of basic obstetric care recommend bed arrest during tocolysis statistically significant more often to their patients than those of higher perinatal care levels (53.6 vs. 32.8%, p=0.0269).

Conclusions
The results of our survey are in accordance to others from different countries and reveal considerable discrepancies between evidence-based guideline recommendations and daily clinical practice.
A novel long noncoding RNA AC125257.1 facilitates colorectal cancer progression by targeting miR-133a-3p/CASC5 axis
Authors: Liao Chuanwen , Zheng Zihan , Liu Junye , Li Jian , Li Rui , Hu Shuqin 
Published: March 2023

Abstract
Colorectal cancer (CRC) is a common malignant gastrointestinal tumor. Long noncoding RNAs (lncRNAs) are revealed to be critically involved in CRC progression, providing new direction for exploring the pathogenesis of CRC. This study aimed to explore the biological functions and regulatory mechanisms of lncRNA AC125257.1 in CRC. Western blotting and reverse-transcription quantitative polymerase chain reaction were used for the measurement of gene expression. Cell counting kit-8 assay and flow cytometry analysis were used to explore the effects of AC125257.1 on CRC cell viability and apoptosis. RNA pull-down and immunoprecipitation assays were performed for validating the binding between AC125257.1 and its potential downstream microRNA. Results showed that lncRNA AC125257.1 expression was upregulated in CRC cells and tumor tissues. AC125257.1 enhanced cell viability and suppressed apoptosis of CRC cells. Moreover, the knockdown of AC125257.1 suppressed CRC progression in vitro and inhibited tumor growth in vivo. miR-133a-3p was revealed to bind with AC125257.1 in CRC cells. CASC5 was proved to be targeted by miR-133a-3p. Moreover, rescue assays indicated that the knockdown of AC125257.1 suppressed the pathogenic overexpression of CASC5. To conclude, AC125257.1 aggravates CRC development via miR-873-5p/CASC5 axis. Our findings might suggest a novel perspective that AC125257.1 may become the target for CRC treatment.
Homes Unbound: Flight, Displacement, and Homing Desire in Exile Persian Poetry
Authors: Shams Fatemeh 
Published: March 2023

Abstract
In the 1980s, a chain of traumatic events in Iran, from an eight-year war to post-revolution political turmoil, forced hundreds of thousands of people to escape their homeland during a wave of mass imprisonment and executions. The exodus included a substantial number of artists, writers, and academics, targeted for their work and beliefs. Their experience gave rise to an important, and woefully overlooked, canon of exilic Persian literature that offers a nuanced and complex documentation of forced displacement, exilic transnational identity, and the troublesome concept of ‘home.’ This essay explores the work of first-generation exiled poets and the ways in which temporal fluctuations of memory and emotion interact with the geographical and corporeal impact of displacement. Drawing on theoretical frameworks of home, migration, and diaspora, the essay challenges ‘home versus exile’ as an oppositional binary, offering a broader definition of exile that rearticulates the meaning of home.
Home Is where the Bees Are! Beekeeping as Homing in Christy Lefteri’s The Beekeeper of Aleppo and Tamara Kotevska and Ljubomir Stefanov’s Honeyland
Authors: ElHalawani Amina 
Published: March 2023

Abstract
Starting with a reading of Christy Lefteri’s refugee narrative The Beekeeper of Aleppo, this article looks into the fragmentation and instability of the notion of home for refugees, highlighting the resort of the characters to a notion of homing as a practice of planetary dimensions. By looking at the role of bees and beekeeping in The Beekeeper of Aleppo and the Macedonian documentary Honeyland home is explored as a ‘verb’ rather than a static location. Moreover, this article also reflects on human and non-human kin, to use Donna Haraway’s term, in the creation of home spaces and relations.
I would like to express my gratitude for the support I have received as a Postdoctoral Fellow at the ICI Berlin Institute for Cultural Inquiry while working on this paper.
Ontogeny and Trophic Factor Sensitivity of Gastrointestinal Projecting Vagal Sensory Cell Types
Authors: McCoy Meaghan E. , Kamitakahara Anna K. 
Published: March 2023

AbstractVagal sensory neurons (VSNs) located in the nodose ganglion provide information, such as stomach stretch or the presence of ingested nutrients, to the caudal medulla via specialized cell types expressing unique marker genes. Here, we leverage VSN marker genes identified in adult mice to determine when specialized vagal subtypes arise developmentally and the trophic factors that shape their growth. Experiments to screen for trophic factor sensitivity revealed that brain-derived neurotrophic factor (BDNF) and glial cell-derived neurotrophic factor (GDNF) robustly stimulate neurite outgrowth from VSNsin vitro. Perinatally, BDNF was expressed by neurons of the nodose ganglion itself, while GDNF was expressed by intestinal smooth muscle cells. Thus, BDNF may support VSNs locally, whereas GDNF may act as a target-derived trophic factor supporting the growth of processes at distal innervation sites in the gut. Consistent with this, expression of the GDNF receptor was enriched in VSN cell types that project to the gastrointestinal tract. Last, the mapping of genetic markers in the nodose ganglion demonstrates that defined vagal cell types begin to emerge as early as embryonic day 13, even as VSNs continue to grow to reach gastrointestinal targets. Despite the early onset of expression for some marker genes, the expression patterns of many cell type markers appear immature in prenatal life and mature considerably by the end of the first postnatal week. Together, the data support location-specific roles for BDNF and GDNF in stimulating VSN growth, and a prolonged perinatal timeline for VSN maturation in male and female mice.