bluuebunny/crossref_metadata_2025_split huggingface dataset:
Processing overwhelms biostimulant‐induced vitamin E improvement in lentils
Authors: Campillos Sílvia , Jené Laia , Munné‐Bosch Sergi 
Published: August 2023

AbstractAlthough biostimulants are used in crop cultivation to improve productivity and/or quality of fruit and vegetables, their effect is rarely investigated up to processed food. Here, we investigated whether vitamin E content in lentils can be influenced by caffeine used as a biostimulant in a greenhouse‐controlled experiment, and how cooking influences its intake in our diet. Results showed that contents of γ‐tocopherol, the most abundant vitamin E homologue, increased by 27% upon biostimulant application during cultivation in raw lentils. However, these positive effects were completely abolished in the processed food, so cultivation differences had no effect on the cooked lentils. Cooking reduced by 43% and 50% of the contents of α‐ and γ‐tocopherols, respectively. A comparative study of vitamin E contents revealed that our lentil variety (variety ‘Pardina’ from ecological origin) contained more vitamin E than any other variety described thus far, with α‐ and γ‐tocopherol contents of 0.86 and 6.83 mg/100 g FW in raw lentils, and 0.49 and 3.42 mg/100 g FW in cooked lentils, respectively. A bowl of cooked ‘Pardina’ lentils, which are very typical in Mediterranean and Middle Eastern diets, can therefore represent a substantial proportion of the daily intake of vitamin E.
Quinic acid ameliorates ulcerative colitis in rats, through the inhibition of two TLR4‐NF‐κB and NF‐κB‐INOS‐NO signaling pathways
Authors: Ghasemi‐Dehnoo Maryam , Lorigooini Zahra , Amini‐Khoei Hossein , Sabzevary‐Ghahfarokhi Milad , Rafieian‐Kopaei Mahmoud 
Published: August 2023

AbstractObjectiveIn this study, the therapeutic effect of quinic acid (QA), which has anti‐inflammatory activity, was investigated on acetic acid‐induced colitis in male Wistar rats.MethodsUlcerative colitis (UC) was induced in rats by acetic acid intrarectally, and the protective effects of QA in 10, 30, 60, and 100 mg/kg doses were investigated. Rats were treated for 5 days and their colon tissues were dissected out at the end. Macroscopic and histopathological examinations were performed in colon tissues. Also, the expression of inflammatory and apoptotic genes, including TLR4, IL‐1β, INOS, IL‐6, TNF‐α, NF‐κB, Caspase‐3, Caspase‐8, Bax, and Bcl‐2, was measured. Biochemistry indices, such as malondialdehyde (MDA) and nitrite oxide (NO) content, in addition to, total antioxidant capacity (TAC), superoxide dismutase (SOD), catalase (CAT), and enzymes activities were also assessed.ResultsColitis increased the levels of MDA and NO, and enhanced the inflammatory and apoptotic gene expressions, while reducing the SOD and CAT enzymes activity, and TAC levels in the colitis rats. Also, results showed that colitis was associated with the infiltration of inflammatory cells, epithelium damage, and edema in colon tissue. QA significantly ameliorated histopathological indices, oxidative stress, inflammation, and apoptosis in colitis rats.ConclusionQA ameliorated UC through the inhibition of two TLR4‐NF‐κB and NF‐κB‐INOS‐NO signaling pathways, which results in the reduction of colitis complications, including oxidative stress, inflammation, apoptosis and histopathological injuries in rats. Therefore it can be concluded, that QA exerts its therapeutic effects through antiapoptotic, antioxidant, and anti‐inflammatory properties.
The characteristics of chest HRCT and pulmonary function tests in lung‐onset primary sjogren's syndrome
Authors: Dong Xin , Gao Yanli , Li Man , Wang Dong , Li Jifeng , Zhang Yongfeng 
Published: August 2023

AbstractIntroductionInterstitial lung disease (ILD) can manifest before the diagnosis of primary Sjögren's syndrome (pSS), however, the underlying mechanisms remain unclear. The aim of this study is to investigate the characteristics of lung‐onset pSS using chest high‐resolution computerized tomography (HRCT) and pulmonary function tests (PFTs).MethodsThe data of 102 patients with pSS‐ILD were retrospectively analyzed. The patients were divided into two groups: lung‐onset group and the nonlung‐onset group. The chest HRCT, PFTs, and clinical and laboratory data were evaluated and compared.ResultsAmong the 102 patients with pSS‐ILD, 59 (57.8%) were lung‐onset and 43 (42.2%) were nonlung‐onset. Chest HRCT in the lung‐onset group showed higher percentage of usual interstitial pneumonia and nonspecific interstitial pneumonia, the difference did not reach statistical significance. The total HRCT score was higher in the lung‐onset group, compared with the nonlung‐onset group (2 [2, 3], vs. 2 [1, 2], p = .014). Total lung capacity (TLC) (%pred) [(75.4 ± 16.2) versus (82.8 ± 19.4), p = .049] and forced vital capacity (FVC) (%pred) [(82.2 ± 19.9) versus (91.6 ± 28.3), p = .050] were significantly lower in the lung‐onset group, compared with the nonlung‐onset group. Residual volume (RV)/TLC (%) significantly increased more than 40% in the lung‐onset group (p = .015). Restricted ventilation disorder, small airway obstruction and reduced diffusing capacity of the lung for carbon monoxide/alveolar volume (%Pred) were more common in the lung‐onset group (p = .038, p = .050, and p = .050, respectively). Correlation analysis showed that HRCT score was positively correlated with the interval between the onset of pulmonary symptoms and the diagnosis of ILD, serum CA125, and serum CEA. TCL (%pred), VC (%pred), FVC (%pred) were negatively correlated with serum CA125.ConclusionLung‐onset is common in pSS patients with more severe lung function impairments. Serum biomarkers, such CA125, CEA, and ALB, were associated with the severity of lung damage.
Preoperative vaginal cleansing with chlorhexidine and cetrimide solution for reduction of postoperative infectious morbidity at a tertiary care center in North India: A prospective cohort study
Authors: Kumari Ankita , Suri Jyotsna , Bharti Rekha , Pandey Divya , Bachani Sumitra 
Published: August 2023

AbstractObjectiveTo determine the effect of preoperative vaginal cleansing with chlorhexidine and cetrimide solution on postoperative infectious morbidity.MethodsThis prospective cohort study was conducted over a period of 18 months in the Department of Obstetrics and Gynecology, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India. Women undergoing cesarean section were alternately allotted to study and control groups. Women with chorioamnionitis, antepartum hemorrhage, rupture of membranes for more than 24 h, and fever in the preoperative period were excluded. The study group received preoperative vaginal cleansing with antiseptic solution (7.5% chlorhexidine w/v and 15% cetrimide w/v); the control group did not receive vaginal cleansing. Both groups were followed for the presence of any infectious morbidity until they were discharged from the hospital.ResultsAge, body mass index (calculated as weight in kilograms divided by the square of height in meters), gestational age, and the parity of the women in the study and control groups were comparable (n = 760). The rate of endometritis was lower in the study group, but the difference was not statistically significant (P = 0.054). Post‐cesarean febrile morbidity and wound sepsis were significantly lower in the study group (P = 0.017 and P = 0.02, respectively). On subgroup analysis, women in the study group with rupture of the membranes before cesarean delivery had lower wound sepsis and a reduced duration of hospital stay. Women in the study group with emergency cesarean delivery showed a significant reduction in wound sepsis, febrile morbidity, and length of hospital stay.ConclusionPreoperative vaginal cleansing with chlorhexidine and cetrimide solution before a cesarean section reduces postoperative infectious morbidity.
Integrating 2D layered materials with 3D bulk materials as van der Waals heterostructures for photodetections: Current status and perspectives
Authors: Liu Weijie , Yu Yiye , Peng Meng , Zheng Zhihua , Jian Pengcheng , Wang Yang , Zou Yuanchen , Zhao Yongming , Wang Fang , Wu Feng , Chen Changqing , Dai Jiangnan , Wang Peng , Hu Weida 
Published: August 2023

AbstractIn the last decade, two‐dimensional layered materials (2DLMs) have been drawing extensive attentions due to their unique properties, such as absence of surface dangling bonds, thickness‐dependent bandgap, high absorption coefficient, large specific surface area, and so on. But the high‐quality growth and transfer of wafer‐scale 2DLMs films is still a great challenge for the commercialization of pure 2DLMs‐based photodetectors. Conversely, the material growth and device fabrication technologies of three‐dimensional (3D) semiconductors photodetectors tend to be gradually matured. However, the further improvement of the photodetection performance is limited by the difficult heterogeneous integration or the inferior crystal quality via heteroepitaxy. Fortunately, 2D/3D van der Waals heterostructures (vdWH) combine the advantages of the two types of materials simultaneously, which may provide a new platform for developing high‐performance optoelectronic devices. Here, we first discuss the unique advantages of 2D/3D vdWH for the future development of photodetection field and simply introduce the structure categories, working mechanisms, and the typical fabrication methods of 2D/3D vdWH photodetector. Then, we outline the recent progress on 2D/3D vdWH‐based photodetection devices integrating 2DLMs with the traditional 3D semiconductor materials, including Si, Ge, GaAs, AlGaN, SiC, and so on. Finally, we highlight the current challenges and prospects of heterointegrating 2DLMs with traditional 3D semiconductors toward photodetection applications.image
Optical imaging of in vivo adoptive T‐cell therapy: State of the art and challenges
Authors: Li Qingshuang , Hu Dehong , Gao Duyang , Gao Guanhui , Zhang Can , Sheng Zonghai 
Published: August 2023

AbstractAdoptive T‐cell therapy (ACT), which is an important type of live cell therapy, has achieved unprecedented success in treating hematological malignancies. Recent studies have shown that ACT is also a promising treatment for solid tumors. Visualizing the in vivo fates (distribution, homing, infiltration, proliferation, and exhaustion) of the immune cells used for ACT (ACT immune cells) is of great importance to promote basic research and clinical translation of ACT. Optical imaging techniques, including bioluminescence, fluorescence, and photoacoustic imaging, have the advantages of high sensitivity, high spatiotemporal resolution, minimal exposure to harmful radiation, and simple instrumentation. Recently, various types of optical imaging probes, including bioluminescence, fluorescence, and photoacoustic imaging probes, have been used to visualize ACT immune cells in vivo and evaluate the molecular mechanism, efficacy, and side effects of ACT. In this review, the optical imaging probes and labeling methods that have been used for in vivo visualization of ACT immune cells are summarized, and the opportunities and challenges of using optical imaging to visualize ACT immune cells in vivo are discussed.
Weight‐adjusted waist as an integrated index for fat, muscle and bone health in adults
Authors: Kim Kyoung Jin , Son Serhim , Kim Kyeong Jin , Kim Sin Gon , Kim Nam Hoon 
Published: August 2023

AbstractBackgroundUnhealthy body composition, including high fat mass, low muscle mass and low bone mass, is a critical health issue in adults. The weight‐adjusted waist index (WWI) estimates fat and muscle mass and may have implications for bone health. We examined its association with body composition outcomes in a large Korean adult cohort.MethodsThis study used data from the Korean National Health and Nutrition Examination Survey (2008–2011). WWI was calculated as waist circumference (cm) divided by the square root of body weight (kg). Dual‐energy X‐ray absorptiometry was used to measure bone mineral density (BMD), appendicular lean mass (ALM) and total body fat percentage. Unhealthy body composition was defined as combined presence of high fat mass, low bone mass and low muscle mass.ResultsA total of 5983 individuals (3034 men [50.7%] and 2949 women [49.3%]; mean age: 63.5 ± 8.7 years) were included. WWI was positively correlated with total body fat percentage (r = 0.478, P < 0.001) and inversely with ALM/weight (r = −0.485, P < 0.001) and BMD at the lumbar spine (r = −0.187, P < 0.001), femoral neck (r = −0.269, P < 0.001) and total hip (r = −0.255, P < 0.001). Higher WWI quartiles correlated with lower BMD, T‐scores and ALM/weight, along with increased total body fat, evident in both genders and more pronounced in women, even after adjusting for confounders. This trend remained statistically significant across WWI quartiles for all analyses (P < 0.001). Higher WWI quartiles were also significantly associated with higher odds of unhealthy body composition, with adjusted odds ratio in the highest WWI group of 18.08 (95% CI, 4.32–75.61) in men and 6.36 (95% CI, 3.65–11.07) in women. The optimal cutoff values of WWI for unhealthy body composition were 10.4 cm/√kg in men and 10.5 cm/√kg in women.ConclusionsIn community‐dwelling adults, high WWI values are associated with unfavourable body composition outcomes, indicating high fat mass, low muscle mass and low bone mass. WWI can potentially serve as an integrated index of body composition, underscoring the need for further research to validate its use in clinical settings.
Dexmedetomidine alleviates propofol‐induced neural injury in developing rats
Authors: Xiao Weiren , Chen Shouren , Chen Jinzhuan , Huang Jianzhong 
Published: August 2023

AbstractPropofol, a commonly used intravenous anesthetic, has been associated with neurodegeneration in the developing brain upon repeated exposure. Dexmedetomidine is an α2 adrenoceptor agonist that was previously reported to possess neuroprotective properties. Here, we confirmed the impacts of dexmedetomidine on propofol‐induced neuroapoptosis and subsequent spatial learning and memory deficits in neonatal rats. We found that dexmedetomidine effectively mitigated propofol‐induced spatial learning and memory impairments and improved aversive memory in developing rats. Dexmedetomidine reduced propofol‐induced cell apoptosis in the hippocampus and modulated the mRNA expression of Bcl‐2 and Bax. Additionally, dexmedetomidine attenuated the propofol‐induced increase of inflammatory factors IL‐6 and TNF‐α. The reduced phosphorylation levels of Akt and CREB levels by propofol were re‐activated by dexmedetomidine. In conclusion, our findings demonstrated that dexmedetomidine effectively mitigated propofol‐induced cognitive and memory impairments in developing rats by modulating apoptosis and reducing inflammation via activating the Akt/CREB/BDNF signaling pathway. These findings suggest potential strategies to protect the developing brain from the adverse effects of anesthetics and improve patient care in pediatric anesthesia practice.
Otherfathering and Black men's mental health: A phenomenological study
Authors: Hannon Michael D. , Ferguson Alfonso L. , Blanchard Raymond A. , Santiago‐Ataande Jasmine E. 
Published: August 2023

AbstractThe authors report the results of a phenomenological study to determine how otherfathering by Black men affects and the potential implications for their mental health. Using interpretative phenomenological analysis, the men reported that otherfathering is rewarding (i.e., internally and externally) and challenging, which has a direct influence on their mental health. Recommendations for counseling practice are provided.
Rheology and delayed micellar formation process of novel tetrameric cationic surfactant fracturing fluid
Authors: Wu Huinan , Fang Bo , Yu Luyao , He Jinlan , Xu Wenting , Xin Hui , Tian Zhenrui , Han Xiaoyang , Lu Yongjun , Xu Ke 
Published: August 2023

AbstractTo enrich the clean fracturing fluid system with high temperature resistance, a novel tetrameric cationic surfactant (TET) was developed and used as a thickener and mixed with different concentrations of sodium salicylate (NaSal) to obtain a new clean fracturing fluid. The flow curves, thixotropy, viscoelasticity, temperature resistance property, and proppant‐suspending capacity were further investigated. The rheological study showed that the Casson model could be used to accurately describe the flow curve of TET/NaSal micelle solutions and the addition of NaSal improved the thixotropy and viscoelasticity of surfactant solution. The optimal mass ratio of TET/NaSal solution was 5/1.5 wt%, and it had good proppant‐suspending capacity. What is more, the retained viscosity of TET/NaSal (5/1.5 wt%) solution was 52.27 mPa·s after shearing at 140°C and 100.0 s−1 for 65 min, which met industry requirements (viscosity > 20 mPa·s) of viscoelastic surfactant fracturing fluids. Moreover, the combination of 10 wt% TET aqueous solution with pH value of 8.51 and 2.6 wt% salicylic acid (HSal) suspension of the same mass significantly delayed micellar formation. The four‐parameter rheo‐kinetics model can be used to fit the viscosity curves of micellar formation, which provided the rheological basis for the study of delayed viscoelastic micellar formation.
Magnetic covalent organic frameworks for extraction and determination of endocrine‐disrupting chemicals in beverage and water samples
Authors: Zhao Jie , Li Zi‐Yu , Yang Chun‐Xu , Li Ya‐Ping , Liu Yu‐Shen , Hu Zhen Hua , Pan Xiao‐Ming , Ma Xiu‐Li , Wang Wei , Yang Xiao‐Shuai , Wang Lu‐Liang 
Published: August 2023

AbstractBACKGROUNDPhenolic endocrine‐disrupting chemicals (EDCs) are widespread and easily ingested through the food chain. They pose a serious threat to human health. Magnetic solid‐phase extraction (MSPE) is an effective sample pre‐treatment technology to determine traces of phenolic EDCs.RESULTSMagnetic covalent organic framework (COF) (Fe3O4@COF) nanospheres were prepared and characterized. The efficient and selective extraction of phenolic EDCs relies on a large specific surface and the inherent porosity of COFs and hydrogen bonding, π–π, and hydrophobic interactions between COF shells and phenolic EDCs. Under optimal conditions, the proposed magnetic solid‐phase extraction‐high‐performance liquid chromatography–ultra violet (MSPE‐HPLC‐UV) based on the metallic covalent organic framework method for phenolic EDCs shows good linearities (0.002–6 μg mL−1), with R2 of 0.995 or higher, and low limits of detection (6–1.200 ng mL−1).CONCLUSIONMagnetic covalent organic frameworks (Fe3O4@COFs) with good MSPE performance for phenolic EDCs were synthesized by the solvothermal method. The magnetic covalent organic framework‐based MSPE‐HPLC‐UV method was applied successfully to determine phenolic EDCs in beverage and water samples with satisfactory recoveries (90.200%–123%) and relative standard deviations (2.100%–12.100%). © 2023 Society of Chemical Industry.
Efficacy and tolerance of photodynamic therapy with methyl‐aminolevulinic acid in early‐stage mycosis fungoides: A real‐life retrospective study
Authors: Barrachin Chloé , Labau Diane , Kolontee Andréa , Debu Anca , Girard Céline , Du Thanh Aurélie , Dereure Olivier 
Published: August 2023

AbstractBackgroundMethyl‐aminolevulinate‐based photodynamic therapy (MAL‐PDT) has been successfully used in early‐stage mycosis fungoides (MF) lesions. However, the long‐term outcome of initially responding lesions has not been systematically investigated to date. To address this issue, we hereby report a large series of early‐stage MF lesions treated with MAL‐PDT and followed up for 1 year after initial treatment.ObjectivesThe objective of this study was to retrospectively evaluate short‐ and middle‐term clinical results of MAL‐PDT on early‐stage MF lesions (patches and plaques) and to identify characteristics possibly predictive of effectiveness.MethodsData from all early‐stage MF lesions (plaques and patches) treated with MAL‐PDT between 2010 and 2017 in a tertiary referral centre were retrospectively collected. Primary endpoints were initial clinical response rated as complete response (CR) or partial response (PR), and the rate of relapse of initially responding lesions was further evaluated 1 year after the last PDT session. Secondary endpoints addressed tolerance and the relevancy of predefined parameters possibly predictive of CR achievement.ResultsA total of 62 lesions from 30 patients with early‐stage MF (21 Ia, nine Ib) were treated and analysed. At the 6‐week evaluation, the overall clinical response rate (RR) was 87.25% (55% CR and 32.25% PR) with a mean of 2.7 PDT sessions per lesion. Twenty‐five percent of initially responding lesions relapsed locally within 1 year. Transient, although significant, pain occurred at least once in 30% of patients. In univariate analysis, the location of lesions on sun‐protected areas was the only parameter statistically related to CR, a result confirmed in multivariate analysis.ConclusionsOverall, these data confirm the interest in the use of MAL‐PDT in early‐stage MF even for deep (folliculotropic) lesions with a higher efficiency on sun‐protected areas. Furthermore, this study demonstrates for the first time that the response is often sustained over time. Accordingly, MAL‐PDT should be considered in the management of early‐stage MF, especially in oligolesional forms or in residual lesions refractory to systemic treatment.
Acute Taste Dysfunction in Oropharyngeal Cancer Patients after Transoral Robotic Surgery
Authors: Tharakan Theresa , Piccirillo Jay F. , Miller Brevin , Reed Danielle R. , Kallogjeri Dorina , Paniello Randall , Puram Sidharth V. , Jackson Ryan S. 
Published: August 2023

ObjectivesTo compare taste changes after transoral robotic surgery (TORS) to taste changes in healthy controls.MethodsOropharyngeal cancer patients receiving TORS and healthy controls were recruited. Participants underwent posterolateral and whole‐mouth psychophysical taste testing (identification, intensity, and hedonics) at baseline and at 2 weeks postoperatively (patients) or follow‐up (controls). Surgeons reported suspension time and glossopharyngeal nerve injury (GNI) based on the identification and sacrifice of the nerve. A Clinical Global Impression (CGI) of taste symptoms was completed at each session (“My sense of taste bothers me” on a 5‐point scale from Never [1] to Always [5]). A taste disorder (TD) was a CGI of 3 (Sometimes) or worse. Within‐subject changes in CGI and psychophysical scores were computed. “Worsened taste” was a CGI increase by ≥1 point at follow‐up.ResultsOf 69 participants, most (33/37 tumor, 31/32 controls) had normal baseline taste (CGI < 3). 14/33 (42%) TORS patients and no controls developed new TDs at follow‐up. More smokers (7/9) had worsened taste than nonsmokers (19/60, difference = 46% [95% CI 16%–76%]). More patients without GNI (6/22) than with GNI (0/15) had postoperative phantogeusia (difference = 27% [95% CI 9–45%]). Tumor‐ipsilateral taste identification (TI) decreased more in patients (−11.3%) than controls (0.8%, difference = 12.2% [95% CI 5.0–19.3%]). Suspension time was not associated with worsened taste symptoms or psychophysical changes.ConclusionsPatient‐reported taste changes after TORS are frequent. Compared to healthy controls, TORS patients have decreased tumor‐ipsilateral TI. Suspension time and GNI are unlikely to cause symptomatic TDs. Further investigations of the etiology and long‐term symptom burden of TORS‐associated TDs will aid in the management of oropharyngeal cancer patients.Level of Evidence3 (non‐randomized controlled cohort study) Laryngoscope, 133:3520–3528, 2023