bluuebunny/crossref_metadata_2025_split huggingface dataset:
Does bicycle sharing reduce traffic congestion? Evidence from mega-cities in China
Authors: Xu Xiaoxia , Liu Jingzhang , Chen Fanglin 
Published: August 2023

Abstract
The development of public transportation is considered as an effective measure to solve the current urban traffic congestion problem. However, research focuses mostly on rail transit systems and buses, and few economic studies systematically identify the effect of shared bicycles on traffic congestion. To fill this gap, this study, which is based on the city-level data of Beijing, Shanghai, and Wuhan in China from 2016 to 2018, uses a regression discontinuity design to test the impact of bicycle sharing on traffic congestion. Results show that first, the implementation of shared bicycle services has significant reduced effects on traffic congestion. Second, based on heterogeneity analysis of different time periods, this study determines that bicycles launched in 2016 have a strong congestion-reducing effect on traffic congestion.. Finally, heterogeneity analysis of different market shares of bicycle brands shows that compared with second-echelon shared bicycles, first-echelon bicycles, including Mobike and OFO, have more significant effects on congestion management. In summary, the implementation of shared bicycle services can reduce traffic congestion, but the government must strengthen standardized management and delivery and strictly monitor the number of shared bicycles.
Preparation of drug-loaded nanofiber membrane / PLA core-coated absorbable surgical suture and its controllable drug release performance
Authors: Yang Zhichao , Liu Shuqiang , Li Jingjing , Wu Gaihong , Li Fu , Zhang Man , Jia Lu , Zhang Yujing , Li Huimin , Liu Xia , Zhao Jingjing , Zhang Huiqin , Li Shiyu 
Published: August 2023

Abstract
Polylactic acid (PLA) surgical suture is considered to be one of the most ideal materials for tissue closure due to its rich raw materials and excellent biological properties. However, surgical sutures face great challenges due to problems such as wound infection and tissue reaction in practical applications. In order to improve the clinical applicability of surgical sutures, we constructed a new drug-loading system for core-spun surgical sutures. The shell was composed of nanofibrous membranes composed of polyglycolic acid (PGA) and polycaprolactone (PCL) and ciprofloxacin (CIP) antibacterial drugs, the core layer adopts PLA filament. By adjusting the composition ratio of polyglycolic acid and polycaprolactone in the shell, a new mode of regulating the release rate and release cycle of the suture was constructed. According to different wound healing time, different drug release cycles of surgical suture were selected. In the study, the higher the shell PGA content and drug loading, the faster the drug release rate. When the carrier ratio polyglycolic acid / Polycaprolactone was 80 / 20 and the drug loading was 3%, the drug release rate was the fastest and the drug release was high. The successful preparation of core-spun yarn surgical suture provides a new idea for the study of new antibacterial surgical suture.
Wood-based Superblack
Authors: Rojas Orlando , Zhao Bin , Shi Xuetong , Khakalo Sergei , Meng Yang , Miettinen Arttu , Turpeinen Tuomas , Mi Shuyi , Sun Zhipei , Khakalo Alexey , Mattos Bruno 
Published: August 2023

Abstract
The promise of superblack materials to revolutionize energy harvesting and optoelectronic technologies has been constrained by their cost and mechanical fragility. Here we report on a simple strategy, guided by computational methods, to develop robust superblack materials following metal-free wood delignification and carbonization (1500 oC). Subwavelength severed cells evolve under shrinkage stresses, yielding vertically aligned fibrillar arrays with a thickness of ~100 µm and light reflectance as low as 0.36 %, on par with conventional superblack materials. The negated light reflection is independent of the incidence angle and wood density. Moreover, our measurements indicate a laser beam reflectivity three-fold lower than commercial light stoppers in current use. Overall, the new wood-based superblack material is introduced as a mechanically strong and cost-effective surrogate for microfabricated carbon nanotube arrays.
A Comparative Study of Flexible Ureteroscopic Lithotripsy for Upper Urinary Tract Stones in Patients with Prior Urosepsis Following Emergency Drainage via Retrograde Ureteral Stent or Percutaneous Nephrostomy
Authors: Sucai Liao , Xu Xiang , Yuan Yuan , Tang Keiyui , Wei Genggeng , Lu Zhengquan , Xiong Lin 
Published: August 2023

Abstract
Background
Patients with urosepsis associated with upper urinary tract stones require further stone management after emergency drainage.
Objective
To evaluate the safety and efficacy of elective flexible ureteroscopic lithotripsy (F-URSL) for upper urinary tract stones in patients with prior urosepsis who have undergone emergency drainage using retrograde ureteral stent(RUS) or percutaneous nephrostomy (PCN).
Method
Between January 2017 and December 2021, clinical data were collected for 102 patients who underwent elective F-URSL following emergency drainage for urosepsis caused by upper ureteral or renal stones. The patients were categorized into two groups based on the drainage method used: the RUS group and the PCN group. The collected data included patient demographics, stone parameters, infection recovery after emergency drainage, and clinical outcomes post F-URSL. Subsequently, the data underwent statistical analysis.
Results
A total of 102 patients were included in the statistical analysis, with 58 (56.86%) in the RUS group and 44 (43.14%) in the PCN group. Among the patients, 84 (82.35%) were female and 18 (17.65%) were male, with an average age of 59.36 years. Positive urine cultures were observed in 71 (69.61%) patients. Successful drainage was achieved in all patients in both groups, and there were no significant differences in the time required for normalization of white blood cell count (WBC) and body temperature following drainage. Additionally, all patients underwent F-URSL successfully, and no statistically significant differences were observed between the two groups in terms of operative time, stone-free rates, postoperative fever, and postoperative hospital stay.
Conclusion
Both RUS and PCN have been established as effective approaches for managing urosepsis caused by upper urinary tract stones. Furthermore, the impact of these two drainage methods on the subsequent management of stones through elective F-URSL has shown consistent outcomes.
Optimal Deployment and Path Planning for Relay Based UAV Assisted Cooperative Wireless Networks for Emergency Scenarios
Authors: Nelapati Lava Prasad , Barathram Ramkumar 
Published: August 2023

Abstract
UAV-assisted wireless communication is crucial for ensuring seamless connectivity and information exchange, particularly in emergency scenarios where timely communication can be a matter of life and death. This paper proposes a UAV-assisted wireless network for emergency applications, utilizing multiple cluster and relay UAVs in rural and semi-urban environments. Each cluster UAV serves the users within its assigned cluster, while the relay UAV facilitates information transfer between uncovered cluster UAVs and the central server. To achieve effective clustering, a medoid-based algorithm is employed for grouping ground users, and mean-shift clustering is utilized to determine the horizontal locations of multiple cluster UAVs. Furthermore, machine learning-inspired stochastic optimization algorithms are used to enhance the optimal path planning of relay UAVs. Monte Carlo simulations were performed to demonstrate the optimality and convergence of the proposed methods in terms of the aggregate of users served and the amount of power saved, which proved to outperform other algorithms in the literature.
Detection and quantification of 5moU RNA modification from direct RNA sequencing data
Authors: Li Jiayi , Sun Feiyang , He Kunyang , Zhang Lin , Meng Jia , Huang Daiyun , Zhang Yuxin 
Published: August 2023

Abstract

Background
Chemically modified therapeutic mRNAs have gained its momentum recently. In addition to commonly used modifications (e.g., pseudouridine), 5moU is considered a promising substitution of uridine in therapeutic mRNAs. Accurate identification of 5-Methoxyuridine (5moU) would be crucial for the study and quality control of relevant IVT mRNAs. However, current methods exhibit deficiencies in providing comprehensive methodologies for detecting such modification. By taking advantage of Oxford nanopore direct RNA sequencing, we present here NanoML-5moU, a machine-learning framework designed specifically for the read-level detection and quantification of 5moU modification.
Results
Nanopore direct RNA sequencing data of 5moU-modified and unmodified control samples were collected. We then examined signal event features (i.e., current intensity means, medians, standard deviations, and dwell time) and classical machine learning algorithms, including Support Vector Machine (SVM), Random Forest (RF), and XGBoost, for 5moU detection within NNUNN (N = A, C, T or G) 5-mers. The signal event features for each base of NNUNN 5-mers, plus the XGBoost algorithm achieved exceptional performance (maximum AUROC = 0.9567 in “AGTTC”, minimum AUROC = 0.8113 in “TGTGC”), substantially surpassing the existing background error comparison model (ELIGOs AUC 0.751 for site-level prediction).
Availability:
The NanoML-5moU framework is publicly available on GitHub (https://github.com/JiayiLi21/NanoML-5moU).
Conclusions
NanoML-5moU enables accurate read-level profiling of 5moU modification with nanopore direct RNA-sequencing, which is also transferable to the detection of other kinds of modifications and biological samples.
An integrated approach towards improvement of writer verification performance using page level, line level and word level data on Bangla handwritten document
Authors: Paul Jaya , Dutta Kalpita , Sarkar Anasua , Roy Kaushik , Das Nibaran 
Published: August 2023

Abstract
Handwriting analysis presents a formidable challenge, especially when dealing with languages like Bangla that lack extensive resources. Previous research on Bangla handwritten document recognition has focused on various levels, including page, block, line, and word analysis. However, the improvement of page-level recognition in this context remains an unexplored area. This paper aims to fill this gap by proposing an integrated approach that combines techniques at the page level, line level, and word level for writer verification. We have developed a novel method that significantly improves the performance of page-level writer verification, utilizing our newly created dataset, JUDVLP-BLWVdb. By utilizing the widely recognized ensemble technique of majority voting, we combine three classifiers (Support Vector Machine, Multilayer Perceptron, and Simple Logistic). Our proposed method achieves a remarkable increase in page level writer verification accuracy, improving by it nearly 12% to 97.62% across 101 different writers. Furthermore, we compare the results of our dataset with four state-of-the-art writer verification approaches. Additionally, we explore the application of deep learning-based approaches, including VGG16, ResNet34, and AlexNet, using our dataset.
A case of pulmonary visceral subpleural hematoma that arose after cardiopulmonary resuscitation treated by hematoma evacuation
Authors: Funaki Yutaka , Hirai Kyoji 
Published: August 2023

Abstract
Background
The occurrence of pulmonary visceral subpleural hematoma as a complication of sternal compressions during cardiopulmonary resuscitation is extremely rare. Also, reports about the treatment of visceral subpleural hematoma are few, and there is room for discussion.
Case presentation
A 58-year-old male with histories of rheumatoid arthritis, chronic atrial fibrillation, hypertension, diabetes, and dyslipidemia developed ventricular fibrillation due to myocardial infarction and fainted. He received bystander cardiopulmonary resuscitation and direct cardioversion by the ambulance crew and had return of spontaneous circulation. After transfer to our hospital, the patient underwent percutaneous catheter intervention and stenting with a diagnosis of myocardial infarction, followed by anticoagulant and antiplatelet therapies. On the 8th hospital day, chest radiography suggested right lower lobe pneumonia, and subsequent chest computed tomography revealed pulmonary hematoma in the visceral subpleural area from S6 to S10. Since no improvement was observed in hypoxemia, treatment was considered necessary. First, an attempt at computed tomography-guided drainage of hematoma was made, but because insertion of the Pig-tail catheter was difficult due to hardness of the hematoma, evacuation of hematoma was performed on the 13th hospital day. The hematoma was located in the visceral subpleural area and was removed by incising the pleura. TachoSil Tissue Sealing sheet® and Polyglycoal acid sheet were applied to the sites of air leakage and oozing after hematoma evacuation. No re-bleeding or air leakage was observed after the treatment, and the patient was discharged on the 26th hospital day after an uneventful course.
Conclusions
Pulmonary visceral subpleural hematoma may occur as a complication of chest compression. In our case, CT-guided puncture and drainage was unsuccessful, and surgical treatment by incision of the visceral pleura and hematoma evacuation alone was effective.
Association of Serum Vitamin D Concentrations with Dietary Intake in a Sample of Jordanian Students
Authors: Al-Qudah Maisa M , Deeb Ammar S. Ali , Al-Jaraedah Thana’ Y , Amawi Kawther , El-Qudah Jafar M. F. , Deeb Amjad Ali , Alkhatib Ahed J 
Published: August 2023

Abstract
Background
Optimal levels of vitamin D are vital for preventive health. However, vitamin D deficiency is still among the most common issues around the world at every age. Consequently, the current study is intended to investigate serum 25(OH)D levels in a sample of Jordanian students. The main aim is to assess the relationship between the estimated diatary intake of vitamin D and the serum of vitamin D, and to conduct biochemicl tests focused on the Jordanian context.
Method
A cross-sectional design has been adopted, 171 students aged between 18 and 25 years. and data collection and analyses were composed of several steps.
Results
The findings of this study revealed that the BMI showed a normal range in the majority of the participants (59.6%). The outcomes of biochemical testing were satisfactory as the levels fell within normal ranges, as mean total hemoglobin, packed cell volume, fasting blood glucose, total cholesterol, triglycerides, HDL-cholesterol, cholesterol/HDL ratio, LDL,and total preotein were 142.9 (g/L), 0.43 (l/l), 4.75 (mmol/L), 4.07 (mmol/L), 1.1 9(mmo/L),1.39 (mmol/L), 3.025, 2.17 (mmol/L), and 77.6 (g/L), respectively. Overall, from the results, it was found that the average dietary intake of students in the current sample was considered good. However, the intakes of folate, zinc, and vitamin B6 were bellow the recomendded intake.
Conclusions
Therefore, it is concluded that there is a need for further maintenance of optimal levels of vitamin D concentrations in their dietary intake to attain more suitable serum levels and overall health outcomes.
Scalable Simulation Algorithm to Generate Large-Scale Botnet Dataset using Role-Mining and Markov Chain
Authors: Bhuiyan Tanveer Hossain , Harun Sarah , Zhang Song , Medal Hugh 
Published: August 2023

Abstract

Detection of malicious networks (botnet) is becoming a major concern as they pose a serious threat to network security. But, botnet detection methods often perform very poorly in real-life datasets as the methods are not developed based on a real-life botnet dataset. A crucial reason for the detection methods not being developed based on a real-life dataset is the scarcity of large-scale, real-life botnet datasets. Due to security and privacy concerns, organizations do not publish their real-life botnet dataset. Realizing the need for a real-life large-scale botnet dataset, in this paper, we develop a simulation methodology to simulate a large-scale botnet dataset from a real-life botnet dataset. This simulation methodology is based on the Markov chain and role-mining approaches. Besides simulating the degree distribution, our simulation methodology also simulates triangles (community structures). We propose a novel scalable algorithm using parallel computing that generates large-scale botnet graphs from a small-size input dataset. To evaluate the performance of our simulation methodology, we compare our simulated graph with the original graph and with the graph simulated by the Preferential attachment (PA) algorithm based on the distributions of triangles, indegrees, and outdegrees. Results demonstrate that the distributions of the simulated graph generated by our methodology are very similar to the distributions of the original graph with minor real-life random variations. Results also demonstrate that our simulation algorithm substantially outperforms the PA algorithm in simulating the distributions of triangles and botnet subgraphs. To emphasize the accuracy of botnet simulation more, we provide a separate comparison between the botnet subgraphs of the simulated and the original graphs that demonstrates the similarity of our simulated botnet subgraphs with the original botnet subgraph. A comparison of our simulated scaled-up graph with the original graph demonstrates that our methodology preserves the triangle distribution and the botnet subgraphs of the original graph, whereas the PA algorithm fails to preserve the triangle distribution and the botnet subgraphs in the scaled-up graph.
Studies on the structure and stimulating effect on Caco-2 cells of flagellin and its truncated proteins of Escherichia coli Nissle 1917
Authors: Li Shuang , Ou Bingming , Wen Ming , Wen Guilan , Yang Ying 
Published: August 2023

Abstract
This study aimed to investigate the structural characteristics and their effects on stimulating Caco-2 cells of Escherichia coli Nissle 1917 flagellin (FliCEcN) and its truncated proteins, FliC△174−506 (D2-D3 domain deleted) and FliC△274−406 (D3 domain deleted). The experiment predicted the tertiary structure of FliCEcN by Alphofold2, analyzed the structural characteristics of FliCEcN, FliC△174−506 and FliC△274−406 by surface-enhanced Raman spectroscopy (SERS) and circular dichroism (CD), and detected the secretion levels of IL-6 (interleukin-6), IL-10 (interleukin-10) and TNF-α (tumor necrosis factor-α) after FliCEcN, FliC△174−506 and FliC△274−406 stimulated Caco-2 cells for 6 and 12 h, respectively. The results showed that the NH3-ends and COOH-ends of FliCEcN were highly conserved, mainly composed of α-helix; the middle domains were highly variable, mainly composed of β-sheet and random coil. The Raman peaks of FliC△174−506 and FliC△274−406 generally maintained the main chain peaks of FliCEcN, while the side chain and amino acid peaks were absent to varying degrees. The composition of the secondary structure of FliC△174−506 and FliC△274−406 was altered. FliCEcN, FliC△174−506 and FliC△274−406 stimulated Caco-2 cells to secrete cytokines IL-10, IL-6 and TNF-α differently. The complete FliCEcN structure could stimulate more secretion of IL-10; the FliC△174−506 group had higher secretion of IL-6; and the FliC△274−406 group had higher secretion of TNF-α. In conclusion, deletion of different domains of the hypervariable region of FliCEcN affects its SERS and CD spectrum and stimulates Caco-2 cells to secrete cytokines.
Prognosis of breast-conserving surgery versus total mastectomy in young breast cancer patients based on SEER and Hebei Province cohort
Authors: Zhang Shuo , Hao Yahui , Shi Jin , Du Xinyu , He Yutong 
Published: August 2023

Abstract
Objective: To investigate the impact of breast-conserving surgery (BCS) and total mastectomy (TM) on the prognosis of young non-metastatic breast cancer patients.
Methods: Surveillance, Epidemiology and End Results (SEER) database was collected for cases from 2010-2015, and patients’ data from 2015-2018 were likewise collected from the Hebei Provincial Tumor Registry. The Chi-square test and Fisher's exact probability method were used to compare differences in clinicopathological characteristics between treatment groups. Using univariate, multivariate Cox regression and propensity score matching (PSM) to analyze the prognosis of patients undergoing different procedures.
Results: A total of 9106 cases were collected from SEER database with a median follow-up time of 75 months. Race, Grade, T-stage, N-stage, histological type, ER status and HER2 status were independent prognostic factors for patients in the BCS group; race, T-stage, N-stage, PR status and HER2 status were independent prognostic factors for patients in the TM group. There was no significant difference in Overall survival (5-year OS rate: 93.2% vs. 93.4%) and Breast cancer-specific survival (5-year BCSS rate: 93.7% vs. 93.9%) between patients in the BCS and TM groups, regardless of before and after PSM (P>0.05). Compared to patients in the BCS group who had better OS than the TM group in 701 cases in Hebei Province (5-year OS rate: 97.0% vs 91.9%, P<0.05). Among patients who received radiotherapy, BCS patients had better OS than TM patients, and among patients with grade I as well as radiotherapy, BCS patients had better BCSS.
Conclusions: The prognosis of patients undergoing BCS is similar to that of patients undergoing TM. As younger patients increasingly undergo BCS, more attention should be paid to the prognosis of this group.
Correlation between surgical position and neck pain after thyroidectomy: a prospective observational study
Authors: Pagliaro Salvatore , Rossi Leonardo , Meligeni Michela , Catani Letizia , Morganti Riccardo , Materazzi Gabriele , Bakkar Sohail , Montanino Antonia , Pagliaro Danilo , Scateni Monica , Pagnucci Nicola 
Published: August 2023

Abstract

Objective: to determine the correlation between the degree of neck hyperextension on the operative table and the postoperative pain in patients undergoing open thyroidectomy.
Background: thyroid diseases are one of the most common health problems worldwide. Although they represent a necessary step in order to perform thyroidectomy, hyperextension of the neck can potentially increase post-operative pain.
Study design and methods: following the STROBE guidelines for observational studies, patients were prospectively enrolled from the cohort of patients operated at the Endocrine Surgery Unit of the University Hospital of XX, between May and July 2021. Both of patients who underwent total thyroidectomy or hemi-thyroidectomy were recruited. The following data were analysed in order to find a correlation with post-operative pain at 24 hours: age, gender, type of surgery, BMI, operative time, degree of neck extension.
Results: overall, 195 patients were enrolled. A direct, statistically significant correlation emerged between the degree of neck hyperextension and the postoperative pain 24 hours after surgery, regardless of the pain of the surgical wound (p< 0.001; Beta 0.270).
Conclusions: a direct correlation emerges between neck tilt angle and postoperative neck pain. Moreover, total thyroidectomy (TT) predisposes more to post-operative neck pain, considering the type of surgery.
Implications for research, policy, and practice: as the neck angle increases on the surgical bed, postoperative pain may increase.