bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Flexible Corn Starch‐Based Biomaterial Device Integrated with Capacitive‐Coupled Memristive Memory, Mechanical Stress Sensing, Synapse, and Logic Operation Functions
Authors: Sun Bai , Chen Yuanzheng , Zhou Guangdong , Zhou Yongzan , Guo Tao , Zhu Shouhui , Mao Shuangsuo , Zhao Yong , Shao Jinyou , Li Yuning 
Published: January 2023

AbstractBiomaterials‐based electronic devices (BEDs) have remarkable advantages such as biocompatibility and biodegradability, which are expected to have promising prospects in the development of green electronics such as wearable smart sensors and brain‐like synaptic devices. However, the development of BEDs is still in its infancy, and much work remains to be done before this technology can be widely used. Here, a novel corn starch‐based BED with a sandwiched structure of Ag/Corn starch:PVDF/ITO is developed, which has integrated multifunctional performance of capacitive‐coupled memristive memory, flexible mechanical stress sensing, synaptic application, and logic operation. Specifically, this device exhibits a wide memristive voltage operating range (1–16 V), a high bending response current (3.5–4.5 µA), long‐term durability synaptic performance, and logic operation capability. These advantageous characteristics endow this device has a good potential to be used in flexible wearable electronics and artificial intelligence.
Insights into the Enhanced Interfacial Stability Enabled by Electronic Conductor Layers in Solid‐State Li Batteries
Authors: Luo Linshan , Sun Zhefei , Gao Haowen , Lan Chaofei , Huang Xiaojuan , Han Xiang , Su Pengfei , Zhang Zhiyong , Li Cheng , Huang Wei , Wei Qiulong , Zhang Qiaobao , Wang Ming‐Sheng , Chen Songyan 
Published: January 2023

AbstractThe (electro)chemical reactions between Li1.3Al0.3Ti1.7(PO4)3 (LATP) solid‐state electrolyte and lithium metal plague the practical applications of LATP. A commonly used strategy to tackle this issue is to construct an ionic conductor layer to stabilize Li/LATP interface. Herein, it is demonstrated that an electronic conductor interlayer (Al or Ag) can also greatly enhance the interfacial stability of Li/LATP. To unveil the origin of the enhanced interfacial stability, a series of techniques, including in situ electron and optical microscopies, kelvin probe force microscopy, and finite element analysis, is exploited. Control experiments show clearly that Al layer can effectively homogenize the electric field distribution, which enables the uniform growth of interphases and thus prevents stress concentration and crack propagation. Moreover, when coupled with solid polymer electrolyte (SPE) to form Al‐SPE bilayer, it can effectively protect LATP from electron attack and interphase formation. Remarkably, Li symmetrical cells with an Al‐SPE bilayer exhibit superior stability of more than 5000 h at 0.2 mA cm−2, among the best cycling performances to date. This work presents an in‐depth understanding of the mechanism of the enhanced interfacial stability enabled by electronic conductor interlayers, as well as a universal interface architecture to boost the cyclability of solid‐state batteries.
Quantitative Understanding of Lithium Deposition‐Stripping Process on Graphite Anodes of Lithium‐Ion Batteries
Authors: Duan Xudong , Li Binqi , Li Jiani , Gao Xiang , Wang Lubing , Xu Jun 
Published: January 2023

AbstractMetallic Lithium deposited on graphite particles is the major phenomenon responsible for the degradation of cell capacity, triggering of internal short circuit (ISC), and exacerbating thermal runaway (TR) in lithium‐ion batteries (LIBs). However, currently, no available physics‐based model can provide an accurate quantitative description of lithium‐plating behavior. Herein, this work establishes a mechanism model to characterize the Li deposition‐stripping process, especially the formation of dead Li and the reversibility of deposited Li. By the combination of the battery model and 3D particle model with the Li deposition‐stripping model, this work enables the quantitative prediction of Li deposition during charging–discharging cycles at various charging rates. Based on the revealed understanding of the Li deposition‐stripping process, a smart charging strategy with the optimization of the minimized Li‐deposition and expedited charging time is proposed. Furthermore, this work also quantifies the influence of anode heterogeneity on Li plating. The results highlight the promise of physics‐based mechanistic modeling for the quantification of the Li disposition‐stripping process and provide fundamental guidance on battery design and charging protocols for next‐generation long cycle life Li‐ion cells.
Sowing Single Atom Seeds: A Versatile Strategy for Hyper‐Low Noble Metal Loading to Boost Hydrogen Evolution Reaction
Authors: Li Qiqi , Zhang Qin , Xu Wenli , Zhao Rong , Jiang Min , Gao Yinhong , Zhong Wenda , Chen Kai , Chen Yongting , Li Xuanke , Yang Nianjun 
Published: January 2023

AbstractThe universal preparation of noble metal single‐atom catalysts (NMSACs) is critical for efficient sustainable energy conversion. In this study, a versatile sowing strategy is proposed to prepare the NMSACs with hyper‐low loading. A metal‐organic framework derived Ni(OH)x with Ni2+ vacancies serves as fertile soil with plentiful trapping holes, where the Pt atom seeds can be inserted. The Pt atoms tend to form tetradentate Pt‐O4 as the roots, confining the loading concentration to a hyper‐low range (≈0.17 wt%). This Pt‐Ni(OH)x catalyst exhibits an overpotential of 58 mV at a current density of 10 mA cm−2 in 1 m KOH for hydrogen evolution reaction and needs only 1.47 V to achieve η10 for water splitting. This approach is extended to the formation of other NMSACs such as Ir and Ru. The versatile sowing strategy thus provides guidance to prepare different NMSACs with excellent catalytic performance.
Engineering Self‐Supported Hydrophobic–Aerophilic Air Cathode with CoS/Fe3S4 Nanoparticles Embedded in S, N Co‐Doped Carbon Plate Arrays for Long‐Life Rechargeable Zn–Air Batteries
Authors: Yan Lei , Xie Binbin , Yang Chen , Wang Yahao , Ning Jiqiang , Zhong Yijun , Hu Yong 
Published: January 2023

AbstractThe highly sluggish kinetics of oxygen reduction/evolution reactions (ORR/OER) at air cathodes lead to problems such as low power density and unsatisfactory cycling life with rechargeable Zn–air batteries (RZABs). To engineer the reaction kinetics at the air cathodes, a hydrophobic–aerophilic strategy is developed to fabricate a self‐supported air cathode based on CoS/Fe3S4 nanoparticles encapsulated in S, N co‐doped carbon plate arrays (CoS/Fe3S4@SNCP). It is experimentally shown that the in situ growth of bimetallic sulfides nanoparticles on the carbon plate arrays improves the intrinsic electrocatalytic activity and electron conduction of the air cathode. Meanwhile, the ab initio molecular dynamics simulations reveal that the hydrophobic–aerophilic surface can repel water molecules to create abundant solid–liquid–gas three‐phase reaction interfaces as well as to expose Fe‐sites, which consequently promote the diffusion of reactive molecules/ions across the interface and the oxygen adsorption. As a result, the CoS/Fe3S4@SNCP electrode exhibits excellent OER and ORR activities with a smaller potential gap of 0.65 V. For the engineered hydrophobicity of the catalyst, the RZAB demonstrates a high power density of 272 mW cm−2, a narrow discharge/charge gap of 0.75 V at 10 mA cm−2, and long‐term cycling stability over 1400 h, outperforming its hydrophilic CoS@SNCP counterparts.
A Symmetry‐Broken Charge‐Separated State in the Marcus Inverted Region
Authors: Sebastian Ebin , Hariharan Mahesh 
Published: January 2023

AbstractWe report a long‐lived charge‐separated state in a chromophoric pair (DC‐PDI2) that uniquely integrates the advantages of fundamental processes of photosynthetic reaction centers: i) Symmetry‐breaking charge‐separation (SB‐CS) and ii) Marcus‐inverted‐region dependence. The near‐orthogonal bichromophoric DC‐PDI2 manifests an ultrafast evolution of the SB‐CS state with a time constant of
=0.35±0.02 ps and a slow charge recombination (CR) kinetics with
=4.09±0.01 ns in ACN. The rate constant of CR of DC‐PDI2 is 11 686 times slower than SB‐CS in ACN, as the CR of the PDI radical ion‐pair occurs in the deep inverted region of the Marcus parabola (
>λ). In contrast, an analogous benzyloxy (BnO)‐substituted DC‐BPDI2 showcases a ≈10‐fold accelerated CR kinetics with
lowering to ≈1536 in ACN, by virtue of a decreased CR driving force. The present investigation demonstrates a control of molecular engineering to tune the energetics and kinetics of the SB‐CS material, which is essential for next‐generation optoelectronic devices.
Enantioselective Intramolecular α‐Arylation of Benzylamine Derivatives: Synthesis of a Precursor to Levocetirizine
Authors: Saunthwal Rakesh K. , Schwarz Maria , Mallick Rajendra K. , Terry‐Wright William , Clayden Jonathan 
Published: January 2023

AbstractA practical, transition metal‐free method allows the enantioselective synthesis of α,α‐diarylmethylamines by asymmetric α‐arylation of benzylamines. Enantioselective lithiation of N′‐aryl‐N‐benzyl‐N‐isopropyl ureas using a chiral lithium amide base generates a benzyllithium that undergoes an unactivated stereospecific intramolecular nucleophilic aromatic substitution to generate an α,α‐diarylmethylamine in the form of its urea derivative, in up to >99 % ee. Treatment with acid induces an “azatropic shift” with retention of configuration, the product of which may be hydrolysed to the target amine.
Halide Layer Cathodes for Compatible and Fast‐Charged Halides‐Based All‐Solid‐State Li Metal Batteries
Authors: Liang Jianwen , Li Xiaona , Kim Jung Tae , Hao Xiaoge , Duan Hui , Li Ruying , Sun Xueliang 
Published: January 2023

AbstractInsertion‐type compounds based on oxides and sulfides have been widely identified and well‐studied as cathode materials in lithium‐ion batteries. However, halides have rarely been used due to their high solubility in organic liquid electrolytes. Here, we reveal the insertion electrochemistry of VX3 (X=Cl, Br, I) by introducing a compatible halide solid‐state electrolyte with a wide electrochemical stability window. X‐ray absorption near‐edge structure analyses reveal a two‐step lithiation process and the structural transition of typical VCl3. Fast Li+ insertion/extraction in the layered VX3 active materials and favorable interface guaranteed by the compatible electrode‐electrolyte design enables high rate capability and stable operation of all‐solid‐state Li‐VX3 batteries. The findings from this study will contribute to developing intercalation insertion electrochemistry of halide materials and exploring novel electrode materials in viable energy storage systems.
A Metabolic‐Tag‐Based Method for Assessing the Permeation of Small Molecules Across the Mycomembrane in Live Mycobacteria**
Authors: Liu Zichen , Lepori Irene , Chordia Mahendra D. , Dalesandro Brianna E. , Guo Taijie , Dong Jiajia , Siegrist M. Sloan , Pires Marcos M. 
Published: January 2023

AbstractThe general lack of permeability of small molecules observed for Mycobacterium tuberculosis (Mtb) is most ascribed to its unique cell envelope. More specifically, the outer mycomembrane is hypothesized to be the principal determinant for access of antibiotics to their molecular targets. We describe a novel assay that combines metabolic tagging of the peptidoglycan, which sits directly beneath the mycomembrane, click chemistry of test molecules, and a fluorescent labeling chase step, to measure the permeation of small molecules. We showed that the assay workflow was robust and compatible with high‐throughput analysis in mycobacteria by testing a small panel of azide‐tagged molecules. The general trend is similar across the two types of mycobacteria with some notable exceptions. We anticipate that this assay platform will lay the foundation for medicinal chemistry efforts to understand and improve uptake of both existing drugs and newly‐discovered compounds into mycobacteria.
Fluorescent Probes Based on AIEgen‐Mediated Polyelectrolyte Assemblies for Manipulating Intramolecular Motion and Magnetic Relaxivity
Authors: Yao Yongkang , Ding Peng , Yan Chenxu , Tao Yining , Peng Bo , Liu Weimin , Wang Junyou , Cohen Stuart Martien A. , Guo Zhiqian 
Published: January 2023

AbstractUniting photothermal therapy (PTT) with magnetic resonance imaging (MRI) holds great potential in nanotheranostics. However, the extensively utilized hydrophobicity‐driven assembling strategy not only restricts the intramolecular motion‐induced PTT, but also blocks the interactions between MR agents and water. Herein, we report an aggregation‐induced emission luminogen (AIEgen)‐mediated polyelectrolyte nanoassemblies (APN) strategy, which bestows a unique “soft” inner microenvironment with good water permeability. Femtosecond transient spectra verify that APN well activates intramolecular motion from the twisted intramolecular charge transfer process. This de novo APN strategy uniting synergistically three factors (rotational motion, local motion, and hydration number) brings out high MR relaxivity. For the first time, APN strategy has successfully modulated both intramolecular motion and magnetic relaxivity, achieving fluorescence lifetime imaging of tumor spheroids and spatio‐temporal MRI‐guided high‐efficient PTT.
CNTs‐coated TPU/ANF composite fiber with flexible conductive performance for joule heating, photothermal, and strain sensing
Authors: He Pengxin , Pu Haihong , Li Xinfeng , Hao Xiaoqiong , Ma Jianhua 
Published: January 2023

AbstractFlexible and highly conductive fiber has attracted considerable attention with its massive potential in functional fabric, stretchable circuits, and wearable electronic devices. Herein, we prepared a novel secondary structure composite fiber based on aramid nanofibers (ANF)‐reinforced thermoplastic polyurethane (TPU) fiber accompanied by carbon nanotube (CNT)‐coated on its surface. The composite fibers' dispersibility, micromorphology, and application were systematically investigated. The TPU/ANF‐0.5 wt% sample showed a robust reinforcing effect, as Young's modulus and tensile strength reached 17.2 and 20.2 MPa, respectively. Meanwhile, the conductive coating layer in the outer frame was formed via a TPU solution with 10 wt% CNT content, which gives the fiber excellent flexible electrical conductivity. Such a unique structural design enables the fiber to be closely attached to human skin and monitor human movement. In addition, this TPU/ANF@CNT composite fiber can also be used for light and electric heating. The photothermal equilibrium temperature can reach 120°C in 50 s, and the electrothermal equilibrium temperature increases to 62°C under 30 V. In summary, this secondary structure composite fiber with excellent electrical and mechanical properties might have great practical application potential in wearable electronic devices.
Three‐dimensional culture of rat ovarian granulosa cells shows increased SPP1 and FGF7 expression through the PI3K/Akt pathway
Authors: Zhang Yaping , Zhu Huasu , Liu Linghong , Ma Huixian , Shi Qing , Li Dong , Ju Xiuli 
Published: January 2023

AbstractOvarian granulosa cells (OGCs) play an essential role in the regulation of follicular growth and development. However, previous studies of OGCs have concentrated on traditional 2D cultures. In the present study, we used the hanging drop culture method to culture rat OGCs (rOGCs) and assessed the effects of 3D conditions on their proliferation and gene expression profiles. Compared with those grown in 2D conditions, rOGCs grown in 3D cultures showed a significantly different spatial cell distribution and cell alignment under electron microscopy. In particular, rOGCs in 3D cultures showed abundant rough and microvilli‐like structures on their cell surface. Here, we showed that these cells grew slowly following 3D culture; the G0/G1‐phase increased and the S‐ and G2/M‐phases decreased. Using whole‐transcriptome sequencing analysis, 501 genes were shown to have been significantly upregulated and 502 were shown to have been downregulated. Differentially expressed genes were most enriched in pathways involved in focal adhesion, MAPK, and PI3K/Akt signaling according to Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis. Western blotting revealed that SPP1 and FGF7 in the PI3K/Akt pathway were significantly upregulated following 3D culture. These findings improve our understanding of OGCs in real 3D environments in vivo and provide possible avenues for future research on OGCs.
Preparation of Ropivacaine Encapsulated by Zeolite Imidazole Framework Microspheres as Sustained‐Release System and Efficacy Evaluation
Authors: Wang Peng , Wang Guangyu , Tang Hongwen , Feng Siwen , Tan Lichuan , Zhang Pu , Wei Guihua , Wang Cuijuan 
Published: January 2023

AbstractThe management of persistent postoperative pain still remains a clinical challenge currently. Although ropivacaine (RVC) is widely used for postoperative analgesia as a local anesthetic, the short half‐life makes it difficult to achieve the desired duration of analgesia. Herein, a RVC sustained‐release microspheres encapsulated by zeolite imidazole framework‐8 (RVC@ZIF‐8) was synthesized for the first time, which prolonged the sustained‐release of RVC and decreased the resulting drug toxicity. RVC can continuously release in vitro for at least 96 h with high drug loading of 30.6 % and RVC@ZIF‐8 had excellent biocompatibility and low cytotoxicity. In sciatic nerve block model, the sensory block time of RVC@ZIF‐8 was significantly prolonged compared with RVC, achieving more than 72 h post injection and no inflammation or lesion were found. Based on high drug loading, ideal sustained‐release and superior biological safety, RVC@ZIF‐8 will be a novel delivery material for local anesthetic with potential application.
Evaluation by Experimentation and Simulation of a FRET Pair Comprising Fluorescent Nucleobase Analogs in Nucleosomes
Authors: Hirashima Shingo , Park Soyoung , Sugiyama Hiroshi 
Published: January 2023

AbstractFörster resonance energy transfer (FRET) is an attractive tool for understanding biomolecular dynamics. FRET‐based analysis of nucleosomes has the potential to fill the knowledge gaps between static structures and dynamic cellular behaviors. Compared with typical FRET pairs using bulky fluorophores introduced by flexible linkers, fluorescent nucleoside‐based FRET pair has great potential since it can be fitted within the helical structures of nucleic acids. Herein we report on the construction of nucleosomes containing a nucleobase FRET pair and the investigation of experimental and theoretical FRET efficiencies through steady‐state fluorescence spectroscopy and calculation based on molecular dynamics simulations, respectively. Distinguishable experimental FRET efficiencies were observed depending on the positions of FRET pairs in nucleosomal DNA. The tendency could be supported by theoretical study. This work suggests the possibility of our approach to analyze structural changes of nucleosomes by epigenetic modifications or internucleosomal interactions.
The survival of childhood leukemia: An 8‐year single‐center experience
Authors: Bordbar Mohammadreza , Jam Nazila , Karimi Mehran , Shahriari Mahdi , Zareifar Soheila , Zekavat Omid Reza , Haghpanah Sezaneh , Mottaghipisheh Hadi 
Published: January 2023

AbstractBackgroundThe survival of childhood leukemia has improved. We aimed to report the survival rate and the associated factors in children with acute leukemia during an 8‐year follow‐up.AimsThis study investigates the 8‐year survival rates of children with acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL) in Shiraz, the largest oncology center in Southern Iran. We also aimed to assess the independent factors associated with higher mortality in childhood leukemia.MethodsChildren 0–18 years with acute leukemia were followed from 2013 to 2021 in Shiraz, Iran. The 8‐year overall survival (OS) and event‐free survival (EFS) rates were estimated by the Kaplan–Meier method. Independent factors associated with survival were assessed by the Cox regression hazard modeling.ResultsWe included 786 children, with 43.5% female, and a mean age of 6.32 ± 4.62 years. Patients with AML compared to ALL experienced more relapse (34.6% vs. 22.5%,p = .01) and death (31.7% vs. 11.3%,p < .001). The cumulative 8‐year OS and EFS were 81% (95% confidence interval (CI), 74.3% to 86.1%) and 68.3% (95% CI, 63.5% to 72.7%) in ALL patients and 63.5% (95% CI, 52.1% to 72.9%) and 43% (95% CI, 33.1% to 52.6%) in AML patients. Multivariable analysis revealed that hepatomegaly (hazard ratio = 4, 95% CI, 1.0 to 22.3,p = .05) was the main independent risk factor of death in ALL patients. No definite risk factor was defined for AML patients.ConclusionThe survival of childhood leukemia has recently increased dramatically in low‐middle income countries. Hepatomegaly was introduced as a potential risk factor for lower survival in ALL patients. Further multicenter studies are needed to confirm the validity of this association.
The Helmholtz‐Kohlrausch effect on display‐based light colors and simulated substrate colors
Authors: High Gregory , Green Phil , Nussbaum Peter 
Published: January 2023

AbstractThe Helmholtz‐Kohlrausch (H‐K) effect is investigated in relation to light colors of every hue, including those typical of print substrate colors that might be simulated on a graphic arts display. A method of adjustment is used in conjunction with a soft‐proof setup, in which an achromatic stimulus is adjusted until it has the same lightness appearance as a set of test colors. Higher chroma colors are found to appear lighter than their metric would indicate. The H‐K effect is found to be quite strong in bluish colors, but negligible in yellowish colors, consistent with several previous studies. However, qualitative analysis reveals a peak H‐K effect in red‐magenta hues. We propose a modification to Fairchild and Pirrotta's existing H‐K lightness appearance function1 which addresses the peak in red hues, and which may prove beneficial in hue‐dependent applications.
Stochastic modeling for energy efficiency in modified directional discontinuous reception for LTE‐5G networks
Authors: Kalita Priyanka , Selvamuthu Dharmaraja 
Published: January 2023

SummaryFifth‐generation (5G) networks deal with high‐frequency data rates, ultra‐low latency, more reliability, massive network capacity, more availability, and a more uniform user experience. To validate the high‐frequency rates, 5G networks engage beam searching operation. By adopting a beam searching state between the short and long sleep, one can reduce the system's delay. The energy consumption of user equipment (UE) in 5G networks is much higher than in the 4G networks. To reduce the energy consumption and increase the energy saving in UE, Long‐Term Evolution (LTE)‐5G networks adopt the discontinuous reception (DRX) scheme with a fixed number of short sleep. LTE‐DRX without beam search operation (i.e., beam alignment) cannot work in 5G networks. Hence, keeping this scenario in mind, we have modeled a new modified directional discontinuous reception (MD‐DRX) mechanism for LTE‐5G networks. The MD‐DRX mechanism captures the behavior of a beam searching, an inactive, an active, a long sleep, an ON, and a short sleep states. The short sleep state consists of a maximum short sleep. To get the optimal energy saving and energy consumption (i.e., energy efficiency) from the MD‐DRX mechanism, it is required to check the system's throughput. The trade‐off between energy saving/energy consumption and throughput will provide the system's optimal energy saving and optimal energy consumption. In this paper, we have obtained the system's optimal energy saving and throughput by optimizing the maximum short sleep and short sleep duration. To get the energy efficiency for LTE‐5G networks, the trade‐off between average energy consumption/energy saving and throughput is shown.