bluuebunny/crossref_metadata_2025_split huggingface dataset:
Benthic foraminiferal growth seasons implied from Mg/Ca‐temperature correlations for three Arctic species
Authors: Skirbekk Kari , Hald Morten , Marchitto Thomas M. , Junttila Juho , Klitgaard Kristensen Dorthe , Aagaard Sørensen Steffen 
Published: August 2023

AbstractCore‐top sediment samples from Kongsfjorden, Svalbard, and adjacent fjord and shelf areas were collected in order to investigate a potential relationship between Mg/Ca‐ratios of Arctic benthic foraminifera and the ambient bottom water temperatures (BWT). The area is influenced by large seasonal variation in factors such as light and temperature, which is further strengthened by oceanographic shifts, including inflow of relatively warm Atlantic water. Four hydrological seasons have been defined. The studied samples were collected during the years 2005–2010 and comprise data from three hydrological seasons: spring, summer, and autumn. Five common species of cold‐water benthic foraminifera were investigated: Islandiella helenae/norcrossi, Buccella frigida, Nonionellina labradorica, Elphidium clavatum, and Cassidulina reniforme. For E. clavatum and C. reniforme, the investigations failed. For the remaining three species, the Mg/Ca‐temperature correlations initially appeared stochastic holding correlation coefficients between 0.01 and 0.15. However, grouping the data based on seasons gave stronger Mg/Ca‐temperature correlations, indicating specific growing seasons for the three species. The equations represent a starting point for a discussion on seasonality rather than robust, “ready‐to‐use” equations. I. helenae/norcrossi seems to reproduce and grow during summer (July/August) in outer Kongsfjorden. For B. frigida, a Mg/Ca‐temperature correlation is seen both in summer (July/August) and autumn (October/November) samples, indicative of a continuous reproduction/growth‐season lasting from July to November. N. labradorica appears to reproduce and grow during autumn (October/November). The results indicate that temperature reconstructions based on these benthic foraminifera reproduce seasonal temperatures rather than annual average temperatures.
Orelabrutinib for the treatment of relapsed or refractory marginal zone lymphoma: A phase 2, multicenter, open‐label study
Authors: Deng Lijuan , Li Zhiming , Zhang Huilai , Huang Haiwen , Hu Jianda , Liu Lihong , Liu Ting , Jin Jie , Zhu Zunmin , Li Wenyu , Huang Zhenqian , Huang Wenrong , Zhou Keshu , Yang Haiyan , Zhang Mingzhi , Ding Kaiyang , Zhou Hui , Hu Yu , Shuang Yuerong , Cao Junning , Gao Sujun , Li Dengju , Sun Zimin , Zhang Qingyuan , Yi Shuhua , Ji Chunyan , Zhang Liansheng , Hou Cheng , Du Yue , Wang Weige , Zhao Renbin , Song Yuqin , Zhu Jun 
Published: August 2023

AbstractMarginal zone lymphoma (MZL) is an indolent type of non‐Hodgkin lymphoma that develops through pathological B cell receptor signaling. Orelabrutinib, a new‐generation oral small molecule Bruton's tyrosine kinase inhibitor, was evaluated in relapsed/refractory (r/r) MZL patients. Previously treated r/r MZL patients received orelabrutinib 150 mg once daily in a phase 2, multicenter, single‐arm study conducted in China. The primary endpoint was overall response rate (ORR) assessed by an Independent Review Committee (IRC) based on the Lugano 2014 classification. Other efficacy, safety, and pharmacokinetic profiles were evaluated as secondary outcome measures. A total of 111 patients were enrolled, of which 90 patients had MZL confirmed by central pathology review, who were mainly with extra‐nodal MZL of mucosa‐associated lymphoid tissue (MALT, 46.7%) and nodal MZL (35.6%). The majority had late‐stage disease, with stage IV accounting for 75.6%. After a median follow‐up duration of 24.3 months, the IRC‐assessed ORR was 58.9% (95% confidence interval [CI], 48.0–69.2), with rates of complete response and partial response being 11.1% and 47.8%, respectively. The IRC‐assessed median duration of response was 34.3 months, and the IRC‐assessed median progression‐free survival (PFS) was not reached with a 12‐month PFS rate of 82.8% (95% CI, 72.6–89.5). The rate of overall survival at 12 months was 91.0% (95% CI, 82.8–95.4). Common all‐grade treatment‐related adverse events (TRAEs) included anemia (27.9%), neutrophil count decrease (23.4%), white blood cell count decrease (18.0%), platelet count decrease (17.1%), blood present in urine (16.2%), rash (14.4%), and upper respiratory tract infection (10.8%). Thirty‐four patients (30.6%) experienced grade 3 or higher TRAEs. Serious TRAEs occurred in 18 patients (16.2%), of which pneumonia (5.4%) was the most common. Seven patients (6.3%) discontinued orelabrutinib due to TRAEs. Orelabrutinib demonstrated high response rates with durable disease remission and was well tolerated in Chinese patients with r/r MZL.
Risk of progression in chronic phase‐chronic myeloid leukemia patients eligible for tyrosine kinase inhibitor discontinuation: Final analysis of the TFR‐PRO study
Authors: Zambrotta Giovanni Paolo Maria , Nicolini Franck E. , Assouline Sarit , Busque Lambert , Pungolino Ester , Abruzzese Elisabetta , Miggiano Maria Cristina , Elena Chiara , Alvarez‐Larran Alberto , Triguero Ana , Iurlo Alessandra , Bucelli Cristina , Cerrano Marco , Capodanno Isabella , Lunghi Francesca , le Coutre Philipp , Galimberti Sara , Caocci Giovanni , Maffioli Margherita , Stagno Fabio , Saussele Susanne , Piazza Rocco , Druker Brian J. , Fava Carmen , Guglielmana Veronica , Colombo Federica , Antolini Laura , Gambacorti‐Passerini Carlo 
Published: August 2023

AbstractDisease progression to accelerated/blast phase (AP/BP) in patients with chronic phase chronic myeloid leukemia (CP‐CML) after treatment discontinuation (TD) has never been systematically reported in clinical trials. However, recent reports of several such cases has raised concern. To estimate the risk of AP/BP among TD‐eligible patients, we conducted TFR‐PRO, a cohort retro‐prospective study: 870 CP‐CML patients eligible for TD formed a discontinuation cohort (505 patients) and a reference one (365 patients). The primary objective was the time adjusted rate (TAR) of progression in relation to TD. Secondary endpoints included the TAR of molecular relapse, that is, loss of major molecular response (MMR). With a median follow up of 5.5 years and 5188.2 person‐years available, no events occurred in the TD cohort. One event of progression was registered 55 months after the end of TD, when the patient was contributing to the reference cohort. The TAR of progression was 0.019/100 person‐years (95% CI [0.003–0.138]) in the overall group; 0.0 (95% CI [0–0.163]) in the discontinuation cohort; and 0.030 (95% CI [0.004–0.215]) in the reference cohort. These differences are not statistically significant. Molecular relapses occurred in 172/505 (34.1%) patients after TD, and in 64/365 (17.5%) patients in the reference cohort, p < .0001. Similar rates were observed in TD patients in first, second or third line of treatment. CML progression in patients eligible for TD is rare and not related to TD. Fears about the risk of disease progression among patients attempting TD should be dissipated.
2024 Update: Advances in the risk stratification and management of large B‐cell lymphoma
Authors: Tavakkoli Montreh , Barta Stefan K. 
Published: August 2023

AbstractDiffuse large B‐cell lymphoma (DLBCL) is a heterogeneous disease with varying clinical outcomes. Our understanding of its molecular makeup continues to improve risk stratification, and artificial‐intelligence and ctDNA‐based analyses have the potential to enhance risk assessment and disease monitoring. R‐CHOP and Pola‐R‐CHP are used in the frontline setting; chimeric antigen receptor therapy (CART) is now the new standard‐of‐care for most with primary refractory disease; both CART and autologous stem cell transplantation are utilized in the relapsed and refractory setting. In this review, we summarize the classification and management of DLBCL with an emphasis on recent advances in the field.
Ultra‐Small Air‐Stable Triplet‐Triplet Annihilation Upconversion Nanoparticles for Anti‐Stokes Time‐Resolved Imaging
Authors: Zhang Bolong , Richards Kieran D. , Jones Beatrice E. , Collins Abigail R. , Sanders Rosie , Needham Sarah R. , Qian Pu , Mahadevegowda Amoghavarsha , Ducati Caterina , Botchway Stanley W. , Evans Rachel C. 
Published: August 2023

AbstractImage contrast is often limited by background autofluorescence in steady‐state bioimaging microscopy. Upconversion bioimaging can overcome this by shifting the emission lifetime and wavelength beyond the autofluorescence window. Here we demonstrate the first example of triplet‐triplet annihilation upconversion (TTA‐UC) based lifetime imaging microscopy. A new class of ultra‐small nanoparticle (NP) probes based on TTA‐UC chromophores encapsulated in an organic–inorganic host has been synthesised. The NPs exhibit bright UC emission (400–500 nm) in aerated aqueous media with a UC lifetime of ≈1 μs, excellent colloidal stability and little cytotoxicity. Proof‐of‐concept demonstration of TTA‐UC lifetime imaging using these NPs shows that the long‐lived anti‐Stokes emission is easily discriminable from typical autofluorescence. Moreover, fluctuations in the UC lifetime can be used to map local oxygen diffusion across the subcellular structure. Our TTA‐UC NPs are highly promising stains for lifetime imaging microscopy, affording excellent image contrast and potential for oxygen mapping that is ripe for further exploitation.
An Asymmetric Hydrogenation/N‐Alkylation Sequence for a Step‐Economical Route to Indolizidines and Quinolizidines
Authors: Zhao Wei , Wang Wenji , Zhou Huan , Liu Qishan , Ma Zhiqing , Huang Haizhou , Chang Mingxin 
Published: August 2023

AbstractThe direct catalytic asymmetric hydrogenation of pyridines for the synthesis of piperidines remains a challenge. Herein, we report a one‐pot asymmetric hydrogenation of pyridines with subsequent N‐alkylation using a traceless Brønsted acid activation strategy. Catalyzed by an iridium‐BINAP complex, the substrates undergo ketone reduction, cyclization and pyridine hydrogenation in sequence to form indolizidines and quinolizidines. The absolute configuration of the stereocenter of the alcohol is retained and influences the formation of the second stereocenter. Experimental and theoretical mechanistic studies reveal that the chloride anion and certain noncovalent interactions govern the stereoselectivity of the cascade reaction throughout the catalytic process.
Multitargeting Prodrugs that Release Oxaliplatin, Doxorubicin and Gemcitabine are Potent Inhibitors of Tumor Growth and Effective Inducers of Immunogenic Cell Death
Authors: Sarkar Amrita , Novohradsky Vojtech , Maji Moumita , Babu Tomer , Markova Lenka , Kostrhunova Hana , Kasparkova Jana , Gandin Valentina , Brabec Viktor , Gibson Dan 
Published: August 2023

AbstractA multitargeting prodrug (2) that releases gemcitabine, oxaliplatin, and doxorubicin in their active form in cancer cells is a potent cytotoxic agent with nM IC50s; it is highly selective to cancer cells with mean selectivity indices to human (136) and murine (320) cancer cells. It effectively induces release of DAMPs (CALR, ATP & HMGB1) in CT26 cells facilitating more efficient phagocytosis by J774 macrophages than the FDA drugs or their co‐administration. The viability of CT26 cells co‐cultured with J774 macrophages and treated with 2 was reduced by 32 % compared to the non‐treated cells, suggesting a synergistic antiproliferative effect between the chemical and immune reactions. 2 inhibited in vivo tumor growth in two murine models (LLC and CT26) better than the FDA drugs or their co‐administration with significantly lower body weight loss. Mice inoculated with CT26 cells treated with 2 showed slightly better tumor free survival than doxorubicin.
In‐Situ‐Formed Potassium‐Modified Nickel‐Zinc Carbide Boosts Production of Higher Alcohols beyond CH4 in CO2 Hydrogenation
Authors: Wang Jia , Wang Tingting , Xi Yongjie , Gao Guang , Sun Peng , Li Fuwei 
Published: August 2023

AbstractNi‐based catalysts have been widely studied in the hydrogenation of CO2 to CH4, but selective and efficient synthesis of higher alcohols (C2+OH) from CO2 hydrogenation over Ni‐based catalyst is still challenging due to successive hydrogenation of C1 intermediates leading to methanation. Herein, we report an unprecedented synthesis of C2+OH from CO2 hydrogenation over K‐modified Ni−Zn bimetal catalyst with promising activity and selectivity. Systematic experiments (including XRD, in situ spectroscopic characterization) and computational studies reveal the in situ generation of an active K‐modified Ni−Zn carbide (K‐Ni3Zn1C0.7) by carburization of Zn‐incorporated Ni0, which can significantly enhance CO2 adsorption and the surface coverage of alkyl intermediates, and boost the C−C coupling to C2+OH rather than conventional CH4. This work opens a new catalytic avenue toward CO2 hydrogenation to C2+OH, and also provides an insightful example for the rational design of selective and efficient Ni‐based catalysts for CO2 hydrogenation to multiple carbon products.
Improved Interfacial Ion Migration and Deposition through the Chain‐Liquid Synergistic Effect by a Carboxylated Hydrogel Electrolyte for Stable Zinc Metal Anodes
Authors: Tian Cong , Wang Jielei , Sun Ruoxuan , Ali Tariq , Wang Hongfei , Xie Bin‐Bin , Zhong Yijun , Hu Yong 
Published: August 2023

AbstractThe large‐scale applicability of Zn‐metal anodes is severely impeded by the issues such as the dendrite growth, complicated hydrogen evolution, and uncontrollable passivation reaction. Herein, a negatively charged carboxylated double‐network hydrogel electrolyte (Gelatin/Sodium alginate‐acetate, denoted as Gel/SA‐acetate) has been developed to stabilize the interfacial electrochemistry, which restructures a type of Zn2+ ion solvent sheath optimized via a chain‐liquid synergistic effect. New hydrogen bonds are reconstructed with water molecules by the zincophilic functional groups, and directional migration of hydrated Zn2+ ions is therefore induced. Concomitantly, the robust chemical bonding of such hydrogel layers to the Zn slab exhibits a desirable anti‐catalytic effect, thereby greatly diminishing the water activity and eliminating side reactions. Subsequently, a symmetric cell using the Gel/SA‐acetate electrolyte demonstrates a reversible plating/stripping performance for 1580 h, and an asymmetric cell reaches a state‐of‐the‐art runtime of 5600 h with a high average Coulombic efficiency of 99.9 %. The resultant zinc ion hybrid capacitors deliver exceptional properties including the capacity retention of 98.5 % over 15000 cycles, energy density of 236.8 Wh kg−1, and high mechanical adaptability. This work is expected to pave a new avenue for the development of novel hydrogel electrolytes towards safe and stable Zn anodes.
Adsorptive removal of dibenzothiophene from model fuel over activated carbon developed by KOH activation of pinecone: Equilibrium and kinetic studies
Authors: Khalid Rand Y. , Fadhil Abdelrahman B. 
Published: August 2023

AbstractActivated carbon (AC) was developed from pinecone using KOH as an activator to eliminate dibenzothiophene (DBT) from a synthetic model of gasoline fuel. The best sample was the AC prepared, employing a 1.5:1 KOH: feed impregnation ratio at 750°C for 1 h. Thus, it was tested in the adsorptive elimination of DBT from the fuel after being identified by X‐ray diffraction (XRD), field‐emission scanning electron microscopy (FESEM), energy dispersive X‐ray (EDX), N2 adsorption–desorption isotherms, pore volume distribution, Fourier transform infrared spectroscopy (FTIR), total basic and acid groups, and pHPZC. The as‐obtained AC exhibited a Brunauer–Emmett–Teller (BET) surface area of 478.89 m2/g with an average pore size of 2.0 nm, indicating its micropores structure. A removal performance of 97.90% was obtained using 0.30 g of AC at 20°C for 30 min, while the adsorptive capacity amounted to 34.38 mg/g as per the Langmuir isotherm. The as‐synthesized AC exhibited a good adsorptive performance for eliminating S compounds from commercial gasoline (42.11%) under the optimal experimental conditions, which increased to 88.16% with increasing the mass of AC implemented in the adsorption process. The adsorption of DBT through the fixed‐bed approach was also adopted, and the results at various flow rates of the effluent through fixed bed of the AC were close to that obtained via the batch‐adsorption system. The regenerated AC exhibited excellent adsorptive performance for DBT until 5 cycles of reuse, reflecting the effectiveness of the obtained AC. Finally, the Langmuir adsorption isotherm and pseudo‐second‐order kinetics model best described the DBT adsorption by the AC developed from pinecone.
Comparing vagus nerve stimulation and resective surgery outcomes in patients with co‐occurring autism and epilepsy to patients with epilepsy alone: A population‐based study
Authors: Subramaniam Varun R. , Mu Lan , Kwon Churl‐Su 
Published: August 2023

AbstractAutism and epilepsy commonly co‐occur. Understanding trends in healthcare utilization and in‐hospital outcomes amongst patients with autism and epilepsy can help optimize care and reduce costs. We compared hospital outcomes amongst patients with autism and epilepsy to those with epilepsy alone undergoing vagus nerve stimulation (VNS) and resective/disconnective surgery. Differences in discharge status, in‐hospital mortality, mean length of stay (LOS), cost and surgical/medical complications were examined. Elective surgical admissions amongst patients with epilepsy alone and co‐occurring autism and epilepsy were identified in the 2003–14 National Inpatient Sample (NIS) using previously validated ICD‐9‐CM case definitions. One patient with co‐occurring epilepsy and autism was matched to three epilepsy patients for age, sex and (1) VNS and (2) resective/disconnective surgery. Multinomial logistic regressions were performed to examine the outcomes of interest. Data were collected on: (1) VNS‐52 (mean age: 12.79 ± 1.03; 19.27% female) hospital admissions in persons with comorbid autism and epilepsy, 156 (mean age: 12.84 ± 0.71; 19.31% female) matched controls with epilepsy alone; (2) resective/disconnective surgery‐113 (mean age: 12.99 ± 0.84; 24.55% female) with comorbid autism and epilepsy, 339 (mean age: 13.37 ± 0.68; 23.86% female) matched controls with epilepsy alone. Compared to patients with epilepsy alone, patients with autism and epilepsy who underwent either surgery showed no differences for in‐hospital mortality, discharge status, mean LOS, hospitalization cost, and surgical/medical complications. Our study shows the feasibility and safety of epilepsy VNS and resective surgery in those with ASD do not differ with those with epilepsy alone, contrary to the prevalent safety concerns of epilepsy surgery in patients with ASD.
Der Neuentwurf zur DEGA Richtlinie 103‐1: Schallschutz im Wohnungsbau – Schallschutzklassen und erhöhter Schallschutz
Authors: Schneider Martin , Nocke Christian , Burkhart Christian 
Published: August 2023

AbstractIn diesem Beitrag wird der Entwurf der DEGA‐Richtlinie 103‐1 : 2023‐05 „Schallschutz im Wohnungsbau Teil 1: Schallschutzklassen und erhöhter Schallschutz“ vorgestellt [1]. Dieser Entwurf basiert auf der DEGA‐Empfehlung 103, Ausgabe 2018. Einsprüche zu diesem Entwurf können bis zum 09. 10. 2023 an die DEGA gesendet werden. Der hier vorgestellte Teil 1 behandelt die Schallschutzklassen mit den dazu gehörenden Anforderungen. In einem noch zu erarbeitenden Teil 2 soll dann der Schallschutzausweis behandelt werden. Im Entwurf wird das Konzept der sieben Schallschutzklassen aus der DEGA‐Empfehlung 103 weitergeführt. Wesentliche Änderung ist die Einführung eines parallelen Konzepts bauteilbezogener und raumbezogener Kenngrößen zum Schallschutz. Bezüglich der subjektiven Wahrnehmung von Geräuschen wird die Anwendung der raumbezogenen Kenngrößen (DnT,w, LnT,w und LAF,max,nT) empfohlen. Die Klassifizierung erfolgt anhand dieser Kenngrößen, kann aber auch mithilfe der bisher gewohnten Größen für die Schalldämmung von Bauteilen (R'w, L'n,w) erfolgen. Die aktuell diskutierten Änderungen bei der geplanten Überarbeitung der DIN 4109 Reihe wurden dabei berücksichtigt.
Ein Beitrag zur Kenntnis der Anomalien des Chroms und seines Verhaltens gegen Wechselstrom bei der Elektrolyse
Authors: Isgarischew N. , Obrutschewa A. 
Published: August 2023

Abstract1. Es wurde die Löslichkeit von Chrom unter dem Einflusse von Gleich‐ und Wechselstrom untersucht; auch die gemeinsame Wirkung beider Ströme in sauren, neutralen und Alkalilösungen.2. Die beobachteten Erscheinungen bekamen eine Erklärung, die sich auf der Annahme einer kolloidalen deckenden Haut gründet. Diese Haut ist die Ursache der Passivität, die ihrerseits die Hauptursache von den vielen Chromanomalien ist.3. Bei der Elektrolyse unter den früher angegebenen Bedingungen löst sich Chrom zwei‐, drei‐ und sechswertig. Die Menge jeder der drei Wertigkeiten des Metalls kann je nach den Verhältnissen verschieden sein.4. Es wurde die eigentümliche aktivierende Wirkung von verschiedenen Anionen und Kationen auf passives Chrom untersucht und vom Standpunkte kolloidchemischer Umwandlungen erklärt.
Kurzvorträge zum Hauptthema. Untersuchung der Sauerstoffbeweglichkeit in Titandioxyd, Quarz und Quarzglas mit Hilfe des heterogenen Isotopenaustausches
Authors: Haul R. , Dümbgen G. 
Published: August 2023

AbstractAus der Abhängigkeit der Austauschgeschwindigkeit von Temperatur und Sauerstoffdruck sowie dem Einfluß von Fremdoxyden ergeben sich Aufschlüsse über die Fehlordnung der untersuchten Oxyde und den Mechanismus der Sauerstoffselbstdiffusion. Die Messungen an TiO2 sprechen für das Vorliegen von Anionenleerstellen. Beim Quarzglas liegen insofern besondere Verhältnisse vor, als eine Wanderung des Sauerstoffs in molekularer Form zu berücksichtigen ist. Die Sauerstoffselbstdiffusion in Quarzkristallen erfolgt im Vergleich zum Quarzglas mit erheblich geringerer Geschwindigkeit.
Über die Reduktion von Oxyd‐Mischkristallen
Authors: Engell H.‐J. , Kohl H. K. 
Published: August 2023

AbstractBei der Reduktion von binären oxydischen Mischkristallen reichert sich die metallische Komponente mit dem geringeren Absolutwert der freien Enthalpie der Oxydbildung in der Metallphase, die andere Komponente in der Oxydphase an. Im stationären Ablauf der Reduktion muß daher ein Materialtransport in der Oxydphase stattfinden. Unter der Annahme von idealem Verhalten von Metall‐ und Oxydphase werden die Transportgleichungen aufgestellt. Es zeigt sich, daß bei ablaufender Reduktion im Oxyd fast ausschließlich das unedlere Metall diffundiert, das edlere Metall dagegen kaum an der Diffusion teilnimmt. Daher muß sich die Metallphase nicht auf der Oberfläche, sondern im Innern des Oxyds ausscheiden. Reduktionsversuche an verschiedenen Oxydmischkristallen bestätigen diese Folgerung.
Crystal Growth by Chemical Transport Reactions II: Equilibrium Measurements in the System Cadmium Sulfide‐Iodine
Authors: Nitsche R. , Richman D. 
Published: August 2023

AbstractThe gas phase equilibria in the system cadmium sulfide‐iodine have been studied in the temperature range 400–800 °C. The total pressure of the reaction mixture as a function of temperature was measured with a quartz Bourdon gauge. Absorption spectroscopy was used to evaluate the iodine concentration in the gas phase. From these data the reaction can be described by

By considering the iodine dissociation as well as the equilibria between the various sulfur species S2, S4, S6, S8, the equilibrium constant for the above reaction is given by

in the entire temperature range studied.