bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pattern-Based Target Selection for Treatment of Irregular Past Tense: A Single-Case Experimental Design for Children With Developmental Language Disorder
Authors: Hannig Russell Kirsten M. , Wilder Amy , Wambaugh Julie L. 
Published: July 2023

Purpose:
Many children with developmental language disorder (DLD) demonstrate difficulty inflecting irregular past tense verbs. We evaluated using phonological-based patterns (i.e., schemas) to select targets for treatment of irregular verb inflection for children with DLD. We hypothesized this approach would result in acquisition of treated verbs, generalization to untreated verbs within the same phonological schema, and increased use of correct irregular verbs in naturalistic contexts.

Method:
Treatment was provided to three 7-year-old participants with DLD in the context of multiple baseline designs across behaviors and participants. Phonological schemas included vowel change, final alveolar, and dual change irregular verbs. Treatment was provided using established therapeutic approaches, including narrative generation, sentence imitation, and naturalistic play activities. Acquisition of treated and untreated targets was assessed at the beginning of sessions, and use of verbs in naturalistic contexts was observed throughout treatment sessions.

Results:
Positive acquisition effects were noted for two of three participants. Generalization to untreated items occurred within and across treatment sets for two participants, whereas increases in accurate irregular verb production in naturalistic contexts were not observed.

Conclusions:
Outcomes demonstrated support for a pattern-based approach to target selection for treatment of irregular past tense verbs. One participant, who demonstrated general difficulty with the probe and treatment tasks, showed no treatment effect, suggesting that the treatment may be effective for some children with DLD. Further research is warranted to determine what factors might have influenced these variable outcomes across participants.

Supplemental Material:

https://doi.org/10.23641/asha.23671500
Diabetische Nephropathie
Authors: Löffler Ivonne , Wolf Gunter 
Published: July 2023

ZUSAMMENFASSUNGDer Einfluss des Geschlechts auf die Prävalenz, das Auftreten und den Verlauf vieler Erkrankungen ist tiefgreifend. In den meisten Fällen wird ein bestimmtes Geschlecht als Risikofaktor für die Genese und Progression der Krankheit angesehen. Dies ist bei der diabetischen Nephropathie (DN) nicht ganz so eindeutig, deren Entwicklung und Schweregrad von vielen Faktoren wie dem Typ und der Dauer des Diabetes mellitus, der Blutzucker- und Blutdruckeinstellung sowie biologisch-genetischen Risikofaktoren abhängen. Insbesondere die Tatsache, dass die Sexualhormonspiegel, die an der Pathophysiologie der Nieren beteiligt zu sein scheinen, durch den Diabetes mellitus selbst dramatisch beeinflusst werden, verdeutlicht die Komplexität der Frage nach den Geschlechtsunterschieden bei DN. Das Hauptziel dieser Übersichtsarbeit ist es, den aktuellen Wissensstand über biologische geschlechtsspezifische Aspekte bei der Genese der DN zusammenzufassen und die Rolle der Sexualhormone zu beleuchten.
Ethics, epistemologies, and relational ontologies in researching children’s cultures
Authors: Deszcz-Tryhubczak Justyna , García-González Macarena 
Published: July 2023

Abstract
This chapter argues for a new materialist and posthumanist understanding of children’s cultures as formed by naturalcultural assemblages destabilizing anthropocentric notions of childhood, adulthood, agency, age, creativity, and text. The chapter provides an overview of recent developments in childhood studies – in particular around the decentering of the child (Spyrou 2017, Diaz-Diaz & Semenec 2020) and the “after childhood” approach (Kraftl 2020) – to propose that they may enable new methodological openings in textual and empirical work with texts and media (co-)created for/by/with young audiences.
Psychophysiological effects of evaluative language use on Twitter complaints and compliments
Authors: Ruytenbeek Nicolas , Allaert Jens , Vanderhasselt Marie-Anne 
Published: July 2023

Abstract
This article explores the role of evaluative language in the identification of emotions in–and psychophysiological
responses to–Twitter complaints and compliments by the readers of these messages. Three hypotheses were tested in this research.
First, in line with recent experimental work in French, we expected the presence of negative evaluative language in complaints to
increase perceived dissatisfaction, impoliteness, and offensiveness by the reader. Second, assuming the negativity bias
hypothesis, stronger psychophysiological responses should be found in complaints compared to compliments. Third, readers’
psychophysiological responses should be stronger for complaints and compliments including evaluative language. To test these
hypotheses, we used a reading task involving cardiovascular reactivity measurements and a questionnaire. We found that perceived
customer dissatisfaction, impoliteness and offensiveness were higher in complaints with vs. without evaluative language. We did
not find an effect of the negativity bias on cardiovascular reactivity. Rather, compliments with evaluative language elicited
larger cardiac slowing compared to complaints (with or without evaluative language) and compliments without evaluative language.
As the stimuli is our study concern a railway company (which is mostly the target of criticism and complaints on Twitter),
participants may have reacted more to the sort of feedback they would not expect the company to receive. Future research will be
necessary to establish whether our findings still hold in the case of companies that achieve a better balance between negative and
positive feedback.
AGHmatrix: genetic relationship matrices in R
Authors: Amadeu Rodrigo R , Garcia Antonio Augusto F , Munoz Patricio R , Ferrão Luís Felipe V 
Published: July 2023

Abstract

Motivation
The resemble between relatives computed from pedigree and genomic data is an important resource for geneticists and ecologists, who are interested in understanding how genes influence phenotypic variation, fitness adaptation, and population dynamics.

Results
The AGHmatrix software is an R package focused on the construction of pedigree (A matrix) and/or molecular markers (G matrix), with the possibility of building a combined matrix of pedigree corrected by molecular markers (H matrix). Designed to estimate the relationships for any ploidy level, the software also includes auxiliary functions related to filtering molecular markers, and checks pedigree errors in large data sets. After computing the relationship matrices, results from the AGHmatrix can be used in different contexts, including on prediction of (genomic) estimated breeding values and genome-wide association studies.

Availability and implementation
AGHmatrix v2.1.0 is available under GPL-3 license in CRAN at https://cran.r-project.org/web/packages/AGHmatrix/index.html and also in GitHub at https://github.com/rramadeu/AGHmatrix. It has a comprehensive tutorial, and it follows with real data examples.
Pleistocene glaciations caused the latitudinal gradient of within-species genetic diversity
Authors: Fonseca Emanuel M , Pelletier Tara A , Decker Sydney K , Parsons Danielle J , Carstens Bryan C 
Published: July 2023

Abstract
Intraspecific genetic diversity is a key aspect of biodiversity. Quaternary climatic change and glaciation influenced intraspecific genetic diversity by promoting range shifts and population size change. However, the extent to which glaciation affected genetic diversity on a global scale is not well established. Here we quantify nucleotide diversity, a common metric of intraspecific genetic diversity, in more than 38,000 plant and animal species using georeferenced DNA sequences from millions of samples. Results demonstrate that tropical species contain significantly more intraspecific genetic diversity than nontropical species. To explore potential evolutionary processes that may have contributed to this pattern, we calculated summary statistics that measure population demographic change and detected significant correlations between these statistics and latitude. We find that nontropical species are more likely to deviate from neutral expectations, indicating that they have historically experienced dramatic fluctuations in population size likely associated with Pleistocene glacial cycles. By analyzing the most comprehensive data set to date, our results imply that Quaternary climate perturbations may be more important as a process driving the latitudinal gradient in species richness than previously appreciated.
Feasibility and tolerability of trofosfamide and etoposide in progressive glioblastoma
Authors: Schmidt Teresa , Agkatsev Sarina , Feldheim Jonas , Oster Christoph , Blau Tobias , Sure Ulrich , Keyvani Kathy , Kleinschnitz Christoph , Stuschke Martin , Herrmann Ken , Deuschl Cornelius , Scheffler Björn , Kebir Sied , Glas Martin , Lazaridis Lazaros 
Published: July 2023

Abstract

Background
Standard of care treatment options at glioblastoma relapse are still not well defined. Few studies indicate that the combination of trofosfamide plus etoposide may be feasible in pediatric glioblastoma patients. In this retrospective analysis, we determined tolerability and feasibility of combined trofosfamide plus etoposide treatment at disease recurrence of adult glioblastoma patients.

Methods
We collected clinicopathological data from adult progressive glioblastoma patients treated with the combination of trofosfamide and etoposide for more than four weeks (one course). A cohort of patients receiving empiric treatment at the investigators’ discretion balanced for tumor entity and canonical prognostic factors served as control.

Results
A total of n = 22 progressive glioblastoma patients were eligible for this analysis. Median progression-free survival (3.1 vs 2.3 months, HR: 1.961, 95% CI: 0.9724–3.9560, P = .0274) and median overall survival (9.0 vs 5.7 months, HR: 4.687, 95% CI: 2.034–10.800, P = .0003) were significantly prolonged compared to the control cohort (n = 17). In a multivariable Cox regression analysis, treatment with trofosfamide plus etoposide emerged as a significant prognostic marker regarding progression-free and overall survival. We observed high-grade adverse events in n = 16/22 (73%) patients with hematotoxicity comprising the majority of adverse events (n = 15/16, 94%). Lymphopenia was by far the most commonly observed hematotoxic adverse event (n = 11/15, 73%).

Conclusions
This study provides first indication that the combination of trofosfamide plus etoposide is safe in adult glioblastoma patients. The observed survival outcomes might suggest potential beneficial effects. Our data provide a reasonable rationale for follow-up of a larger cohort in a prospective trial.
Cross-sectional Characterization of SARS-CoV-2 Antibody Levels and Decay Rates Following Infection of Unvaccinated Elderly Individuals
Authors: Whelan Marilyn , Galipeau Yannick , White-Al Habeeb Nicole , Konforte Danijela , Abou El Hassan Mohamed , Booth Ronald A , Arnold Corey , Langlois Marc-André , Pelchat Martin 
Published: July 2023

Abstract

Background
SARS-CoV-2 infections have disproportionally burdened elderly populations with excessive mortality. While several contributing factors exists, questions remain about the quality and duration of humoral antibody–mediated responses resulting from infections in unvaccinated elderly individuals.

Methods
Residual serum/plasma samples were collected from individuals undergoing routine SARS-CoV-2 polymerase chain reaction testing in a community laboratory in Canada. The samples were collected in 2020, before vaccines became available. IgG, IgA, and IgM antibodies against SARS-CoV-2 nucleocapsid, trimeric spike, and its receptor-binding domain were quantified via a high-throughput chemiluminescent enzyme-linked immunosorbent assay. Neutralization efficiency was also quantified through a surrogate high-throughput protein–based neutralization assay.

Results
This study analyzed SARS-CoV-2 antibody levels in a large cross-sectional cohort (N = 739), enriched for elderly individuals (median age, 82 years; 75% &gt;65 years old), where 72% of samples tested positive for SARS-CoV-2 by polymerase chain reaction. The age group ≥90 years had higher levels of antibodies than that &lt;65 years. Neutralization efficiency showed an age-dependent trend, where older persons had higher levels of neutralizing antibodies. Antibodies targeting the nucleocapsid had the fastest decline. IgG antibodies targeting the receptor-binding domain remained stable over time, potentially explaining the lack of neutralization decay observed in this cohort.

Conclusions
Despite older individuals having the highest levels of antibodies postinfection, they are the cohort in which antibody decay was the fastest. Until a better understanding of correlates of protection is acquired, along with the protective role of nonneutralizing antibodies, booster vaccinations remain important in this demographic.
Low Rates of Antifungal Therapeutic Drug Monitoring Among Inpatients Who Received Itraconazole, Posaconazole, or Voriconazole, United States, 2019–2021
Authors: Benedict Kaitlin , Gold Jeremy A W , Toda Mitsuru , Thompson George R , Wiederhold Nathan P , Smith Dallas J 
Published: July 2023

Abstract
Antifungal therapeutic drug monitoring (TDM) is recommended for hospitalized patients receiving itraconazole, posaconazole, or voriconazole for treatment or prophylaxis. In this analysis of hospital-based data, TDM was uncommonly performed (15.8%) in a large cohort of eligible patients, suggesting missed opportunities to avoid subtherapeutic drug levels and minimize toxicity.
Relapsing Babesiosis With Molecular Evidence of Resistance to Certain Antimicrobials Commonly Used to Treat Babesia microti Infections
Authors: Marcos Luis A , Wormser Gary P 
Published: July 2023

Abstract
Human babesiosis cases are emerging with an increased incidence and a wider geographic range worldwide. Relapsing babesiosis cases are becoming more frequently encountered in clinical practice associated with the use of immunosuppressive medications. The 2020 Infectious Diseases Society of America babesiosis guideline recommends at least 6 weeks of antimicrobial treatment for highly immunocompromised patients with Babesia microti infection. Nevertheless, cases have relapsed even after 6 weeks of treatment. Genetic mutations regarded as the potential cause of antimicrobial resistance in B microti have been identified in certain relapsing cases. A few alternative antimicrobial regimens have been used successfully to achieve cure for some of these cases, but other cases have had fatal outcomes. In this review, we discuss the molecular evidence of genetic resistance to certain antimicrobials commonly used to treat B microti infections based on an evaluation of 9 patients with relapsing infection.
Control of porphyria cutanea tarda with anti-IL-17 secukinumab in a person with psoriasis living with HIV
Authors: Bedier Helbies , Isnard Stéphane , Thomas Réjean , Routy Jean-Pierre 
Published: July 2023

Abstract
A 65-year-old woman successfully treated for human immunodeficiency virus (HIV) and Hepatitis C virus was diagnosed with porphyria cutanea tarda (PCT) and treated by phlebotomies. She developed extensive psoriatic skin lesions resistant to topical treatments and methotrexate. She then received the anti-interleukin-17 (IL-17) secukinumab (Cosentyx) which improved her psoriatic skin lesions. Unexpectedly, her PCT skin lesions healed, allowing phlebotomy discontinuation over 2 years. Without lesions, the patient decided to discontinue secukinumab, leading to the recurrence of psoriatic and PCT skin lesions, which were controlled upon therapeutical rechallenge. No AIDS-related manifestations or infections developed, her CD4 count remained elevated and her HIV viral load was controlled under antiretroviral therapy. Both skin conditions and consequently the patient’s quality of life have improved with secukinumab, allowing exposure to sunlight and phlebotomy discontinuation for &gt;4 years. Likely, the IL-17 pathway is involved in the clinical manifestations of PCT, opening new avenues for therapeutical interventions.
Delayed diagnosis of severe diabetic ketoacidosis associated with a sodium-glucose cotransporter 2 inhibitor: a case report
Authors: Taniguchi Hiroaki , Terayama Takero , Seno Soichiro , Kiriu Nobuaki , Kato Hiroshi , Sekine Yasumasa , Kiyozumi Tetsuro 
Published: July 2023

Abstract
Sodium-glucose cotransporter 2 (SGLT2) inhibitors are used to treat patients with type 2 diabetes mellitus but may induce diabetic ketoacidosis (DKA). Owing to their pharmacological mechanisms, they cause a different pathogenesis to that of typical DKA and require special attention in terms of blood glucose concentrations and acidosis. We describe a case of prolonged acidosis because of failure to immediately discover the use of an SGLT2 inhibitor. Compared with typical DKA, SGLT2 inhibitor-associated DKA requires earlier and longer glucose supplementation. SGLT2 inhibitors are specific aetiological factors in DKA, and their use should be suspected when the patient presents with mild hyperglycaemia or prolonged acidosis.
Immersive Reflexivity
Authors: Jordan Randolph 
Published: July 2023

Abstract
This chapter examines Peter Mettler’s film Picture of Light (1994) as an exploration of what is at stake in the debates about the documentary recording practices essential to soundscape research. Mettler and his crew travel to Churchill, Manitoba, and attempt to capture the aurora borealis on film. They take an overtly reflexive strategy that foregrounds the filmmaking process while continually questioning if our experience of the lights on film could be anything like being there in person. Asking what it might mean to hear the lights, they stage the soundscape of Churchill in ways that continually challenge the limits of documentary representation while meditating upon the role of media in shaping our engagement with the world they seek to document. This chapter argues that Mettler’s use of sound calls attention to how we perform with our media as the very basis of our engagement with the world, a strategy the author calls immersive reflexivity: the foregrounding of mediality as a tool for engagement rather than distanciation. This chapter situates Mettler’s strategy within the long history of experimental film, particularly visual music, and its attempts at generating more holistic experiences through self-conscious means, particularly with respect to sound/image relationships. By framing Picture of Light through the discourses of documentary and experimental film, this chapter demonstrates how Mettler’s film teaches us to address the practice of field recording in soundscape research as highly staged material that can, nevertheless, provide faithful means of engaging with the world that presents itself to the microphones.
The Schizophonographic Imagination
Authors: Jordan Randolph 
Published: July 2023

Abstract
This chapter focuses on one particular sound technology, the phonograph, as a highly visual marker of the myth of vanishing mediation at the crux of the fidelity thesis, ideal for cinematic evocations of the schizophonic condition. With David Lynch and Mark Frost’s Twin Peaks saga as a case study, the author uses the term schizophonographics to refer to cinema’s capacity to represent the split between sound and source through graphic representation of the materiality of phonographic processes. Lynch’s career-long interest in phonography inverts the fidelity thesis by fetishizing the materiality of the medium as the basis for its capacity to vanish. With reference to scholarship on early twentieth century anxieties surrounding sound and image recording technologies, and late twentieth century anxieties around the shift to digital processes, this chapter demonstrates where Twin Peaks sits in the context of Lynch’s history of schizophonographics to bind alternate modes of perception to medium-specific materiality. Twin Peaks ties its schizophonographics to questions of neurodivergence in its narrative focal point: the figure of Laura Palmer, the high school senior found murdered in the opening minutes of the pilot episode, and whose troubled life unfolds through the police investigation that follows. Her character’s psychological instability drives much of the formal experimentation with sound and image in the series, but through it we find a more productive way to engage with Schafer’s negative evocation of schizophrenia in articulating the presence of sound technologies in our daily lives that moves beyond aging critiques of the postmodern condition.
Jeremiah and the Prophetic Book as Narrative
Authors: Mastnjak Nathan 
Published: July 2023

Abstract
The transformation of the Jeremiah collection into the book of Jeremiah happened at least twice, giving us the significantly different books attested in the LXX and MT. Chapter 6 examines both versions of Jeremiah as independent bookmaking acts. An examination of the arrangement of each book as well as particular plusses unique to each text-type shows the Jeremianic bookmakers editing and arranging the Jeremiah collection in the interest of a narrative reading of the book. The two books of Jeremiah tell different stories. MT Jeremiah tells a story of the last days of the kingdom of Judah that is ultimately oriented toward hope for the future. The LXX, by contrast, tells a story that emphasizes the finality of the destruction of Judah and limits the scope of any future restoration to the exiles of 597 bce.
Narrative in the Books of Ezekiel
Authors: Mastnjak Nathan 
Published: July 2023

Abstract
Like the books of Jeremiah, the manuscript evidence for the Ezekiel traditions attests two distinct books. The late second-/early third-century Papyrus 967 attests an arrangement of the Greek version of Ezekiel that differs from the arrangement of the MT and LXX. This chapter explores these two books of Ezekiel and explains their differences in light of the collection-model of material textuality. The two books of Ezekiel arose as independent efforts at creating a single book-scroll out of the multi-scroll Ezekiel literature. This chapter also examines unique textual features of each book that suggest the Hellenistic Ezekiel bookmakers, like those responsible for the books of Jeremiah, organized and edited the Ezekiel corpus in the interest of its narrative shape. The narrative impulses of these bookmakers participate in larger cultural trends within Hellenistic Judaism that were deeply concerned with incorporating Israel’s literary patrimony into large-scale accounts of Israel’s history.