bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quality of life of adolescent and adult survivors of childhood cancer in Europe—A systematic review
Authors: Larsen Pia Alkærsig , Amidi Ali , Ghith Nermin , Winther Jeanette Falck , Pedersen Camilla 
Published: June 2023

AbstractAdvances in diagnostics and treatment of childhood cancer during the past few decades have substantially increased survival, resulting in a growing population of survivors of childhood cancer. Somatic and mental late effects of the cancer and the treatment may impact the quality of life (QoL). Previous reviews of QoL in survivors of childhood cancer have shown contradictory findings across studies and the majority of studies included have been based on data from North America and may not be directly comparable to a European setting. The aim of our study was to critically evaluate and summarise the latest evidence on the QoL of childhood cancer survivors in Europe and to identify survivors at particular risk. The eligible studies were published between 2008 and 2022, conducted in Europe and included participants who had survived at least 5 years after diagnosis of a childhood cancer. The main outcome of interest was QoL of survivors which was measured with validated qualitative and quantitative QoL questionnaires. A systematic literature search conducted in PubMed, EMBASE, PsycINFO and CINALH resulted in inclusion of 36 articles with a total of 14 342 survivors of childhood cancer. The majority of included studies found that childhood cancer survivors reported poorer QoL than comparisons. Female gender, treatment with haematopoietic stem cell transplantation and a brain tumour diagnosis were associated with lower QoL. With a growing population of childhood cancer survivors with many years ahead of them, targeted interventions and optimal follow‐up care are important to improve the QoL of survivors.
Setting Current Context for Agility in the Future of Systems Engineering
Authors: Dove Rick 
Published: June 2023

ABSTRACTAgility in the future of systems engineering (FuSE) is one of the topic areas under the INCOSE FuSE initiative. A roadmap for near‐term improvement, presented at the 2021 INCOSE International Symposium, offered nine strategic concepts appropriate and ready for further movement toward standard practice. Initial work in that direction enticed several practitioners and researchers to address selected concepts in this special issue of the INCOSE INSIGHT publication. The purpose of this lead‐off article is to provide a contextual backdrop for the articles that follow.
Systems Engineering Agility in a Nutshell
Authors: Dove Rick , Lunney Kerry , Orosz Michael , Yokell Mike 
Published: June 2023

ABSTRACTSystems engineering must necessarily have the agility to anticipate and effectively respond to an increasingly dynamic and uncertain environment. Agile systems engineering, agile software engineering, and agile any‐kind‐of engineering share common goals and leverage common agility‐enabling strategies. This article succinctly describes eight strategic aspects with application discussions at the systems engineering level.
Project Lifecycle Development for a Next Generation Space Suit Project
Authors: Cabrera Michael A. , Simske Steve 
Published: June 2023

ABSTRACTA hypothesis for an optimized, project lifecycle development method was formulated by understanding (i) the project environment of implementation, (ii) applicable, current state‐of‐the‐art frameworks, and (iii) eliciting feedback before, during and after testing from those individuals participating in the lifecycle development framework. While traditional waterfall methods have their place, high uncertainty projects instigate exploratory work and as such, agile implementations were created to allow projects to quickly adapt (PMI 2017). In the context of dynamic environments and niche products, NASA is no stranger. Understanding the current state of the project and current state‐of‐the‐art facilitates an approach that allows for well‐established techniques in the way of lean and agile to benefit project development. Additionally, these inclusions may help expose knowledge gaps in the current state‐of‐the‐art and also lend credibility to approaches derived to help close those gaps. This article describes the modified agile concept (MAC) and its multi‐disciplinary approach to a sampling of various lean and agile methods integrated alongside traditional, waterfall methods (such as a hybrid model) to support the hypothesized project lifecycle development. This approach was developed as part of a case study with a design and test team responsible for building test stations to qualify components of the life support system on the next generation space suit. This article will outline exclusively the scrum and lean methods in the MAC with a cursory overview on kanban development supporting the MAC.
Characterization of tele‐pharmacy interventions performed via an expanded tele‐critical care pharmacist protocol
Authors: Griffiths Carrie L. , Kosmisky Desiree E. , Everhart Sonia S. , Smith Katelyn A. 
Published: June 2023

AbstractBackgroundTo enhance patient care during the COVID‐19 pandemic, tele‐critical care (TCC) pharmacists within Atrium Health (AH) managed therapy in multiple domains under a Critical Care Pharmacist Emergency Protocol Agreement (CCPEPA).MethodsThis was a multicenter, retrospective quality improvement (QI) study conducted at AH's North Carolina facilities to compare TCC pharmacist interventions between shifts (timeframes 1 and 2), identify and categorize medication management interventions (timeframe 3), and to assess how the CCPEPA was utilized during these different timeframes.ResultsAfter removing duplicate patients and interventions that were recorded in overlapping timeframes, 5681 interventions were performed on 1665 unique patients. Timeframe 1 documented 2150 interventions on 861 patients with an average of 37.2 interventions/shift on first shift and 14.3 interventions/shift on second shift. Medication management (46.5%) was the most common activity on first shift whereas glucose management activities (42.8%) were most common on second shift. During timeframe 2, the full time TCC pharmacists documented 710 interventions on 395 patients with an average of 15.8 interventions/shift on first shift and 11.3 interventions/shift on second shift. Activity results were similar to timeframe 1. During timeframe 3, 2331 medication management interventions were performed on 700 patients, averaging 18.4 interventions/day, including medication discontinuation (39.2%), medication addition (15.7%), and order clarification (11.8%). The most common medication class was sedation and analgesia (26.3%).ConclusionsThe CCPEPA provided TCC pharmacists various opportunities to enhance patient care and practice at the top of their license. First shift hours with proactive patient review for both faculty and full‐time TCC pharmacists resulted in more interventions per shift and increased medication management interventions. These QI initiatives demonstrate the benefit of having TCC pharmacists as part of the healthcare team. Within AH, the success of the CCPEPA protocol has supported advocating for Clinical Pharmacist Practitioner status and increases in TCC pharmacist staff.
Therapy plans for therapeutic apheresis in Epic HealthLink
Authors: Jain Vansh S. , Li Huihua , Lee Kristin P. , Rose William Nicholas 
Published: June 2023

AbstractBackgroundA common required duty of pathology resident physicians while rotating on transfusion medicine is the medical oversight of the therapeutic apheresis service. A task often performed on this clinical medicine service is formulating and writing orders for therapeutic apheresis procedures. The EpicCare tool called the therapy plan provides unique advantages over a standard electronic order set for therapeutic apheresis.Materials and MethodsTransfusion medicine physicians, apheresis nurses, pharmacists, and information technology professionals collaborated to create therapy plans for three therapeutic apheresis procedures: plasmapheresis, red cell exchange, and photopheresis.ResultsTherapy plans were implemented and have been well‐received for several years. Over a six‐year time period, a total of 613 therapy plans were created and signed. We speculate that this implementation may have increased both physician efficiency and patient safety.ConclusionThis article reports our experience using therapy plans in EpicCare in order to raise awareness of this tool and to serve as an encouragement for wider adoption.
Can we diagnose mental disorders in children? A large‐scale assessment of machine learning on structural neuroimaging of 6916 children in the adolescent brain cognitive development study
Authors: Gaus Richard , Pölsterl Sebastian , Greimel Ellen , Schulte‐Körne Gerd , Wachinger Christian 
Published: June 2023

AbstractBackgroundPrediction of mental disorders based on neuroimaging is an emerging area of research with promising first results in adults. However, research on the unique demographic of children is underrepresented and it is doubtful whether findings obtained on adults can be transferred to children.MethodsUsing data from 6916 children aged 9–10 in the multicenter Adolescent Brain Cognitive Development study, we extracted 136 regional volume and thickness measures from structural magnetic resonance images to rigorously evaluate the capabilities of machine learning to predict 10 different psychiatric disorders: major depressive disorder, bipolar disorder (BD), psychotic symptoms, attention deficit hyperactivity disorder (ADHD), oppositional defiant disorder, conduct disorder, post‐traumatic stress disorder, obsessive‐compulsive disorder, generalized anxiety disorder, and social anxiety disorder. For each disorder, we performed cross‐validation and assessed whether models discovered a true pattern in the data via permutation testing.ResultsTwo of 10 disorders can be detected with statistical significance when using advanced models that (i) allow for non‐linear relationships between neuroanatomy and disorder, (ii) model interdependencies between disorders, and (iii) avoid confounding due to sociodemographic factors: ADHD (AUROC = 0.567, p = 0.002) and BD (AUROC = 0.551, p = 0.002). In contrast, traditional models perform consistently worse and predict only ADHD with statistical significance (AUROC = 0.529, p = 0.002).ConclusionWhile the modest absolute classification performance does not warrant application in the clinic, our results provide empirical evidence that embracing and explicitly accounting for the complexities of mental disorders via advanced machine learning models can discover patterns that would remain hidden with traditional models.
(Un)equal demands and opportunities: Conceptualizing student navigation in undergraduate engineering programs
Authors: Lee Walter C. , Hall Janice L. , Josiam Malini , Pee Crystal M. 
Published: June 2023

AbstractBackgroundIt is well known that earning a bachelor's degree in engineering is a demanding task, but ripe with opportunity. For students from historically excluded demographic groups, this task is exacerbated by oppressive circumstances. Although considerable research has documented how student outcomes differ across demographic groups, much less is known about the dynamic processes that marginalize some students.PurposeThe purpose of this article is to propose a conceptual model of student navigation in the context of undergraduate engineering programs. Our goal is to illustrate how localized, structural features unjustly shape the demands and opportunities encountered by students and influence how they respond.Scope/MethodWe developed our model using an iterative, four‐stage process. This process included (1) clarifying the purpose of the development process; (2) identifying concepts and insights from prior research; (3) synthesizing the concepts and insights into propositions; and (4) visualizing the suspected relationships between the salient constructs in the propositions.ResultsOur model focuses on the dynamic interactions between the characteristics of students, the embedded contexts in which they are situated, and the support infrastructure of their learning environment.ConclusionThe resulting model illustrates the influence of structural features on how students a) respond to demands and opportunities and b) navigate obstacles present in the learning environment. Although its focus is on marginalized students in undergraduate engineering programs, the model may be applicable to STEM higher education more broadly.
Familial immune‐mediated aplastic anaemia in six different families
Authors: Imi Tatsuya , Mizumaki Hiroki , Hosomichi Kazuyoshi , Nannya Yasuhito , Zaimoku Yoshitaka , Yoroidaka Takeshi , Katagiri Takamasa , Ishiyama Ken , Yamazaki Hirohito , Ogawa Ryosuke , Kuroiwa Mika , Tajima Atsushi , Ogawa Seishi , Nakao Shinji 
Published: June 2023

AbstractWe studied the pathophysiology of aplastic anaemia (AA) in six different pairs of relatives without a family history of hematologic disorders or congenital AA. Five and four of the six pairs shared the HLA‐DRB1*15:01 and B*40:02 alleles, respectively. Glycosylphosphatidylinositol‐anchored protein‐deficient blood cells were detected in eight of the 10 patients evaluated. In a mother‐daughter pair from one family, flow cytometry detected leukocytes lacking HLA‐A2 due to loss of heterogeneity in chromosome 6p. Whole‐exome sequencing of the family pair revealed a missense mutation in MYSM1. These results suggest that genetic inheritance of immune traits might underlie familial AA in some patients.
A mixed‐methods evaluation of why an implementation trial failed to engage veterans with posttraumatic stress disorder in trauma‐focused psychotherapy
Authors: Fortney John C. , Rajan Suparna , Chen Jessica A. , Campbell Sarah B. , Nolan John P. , Wong Edwin , Sayre George , Petrova Valentina , Simons Carol E. , Reisinger Heather S. , Schnurr Paula P. 
Published: June 2023

AbstractAn effectiveness trial found that telemedicine collaborative care for posttraumatic stress disorder (PTSD) significantly increased engagement in trauma‐focused psychotherapy (TFP) and improved PTSD symptoms. However, in a subsequent implementation trial, very few veterans enrolled in collaborative care initiated TFP. We conducted a mixed‐methods evaluation to determine why veterans did not initiate TFP in the implementation trial. After conducting chart reviews of 1,071 veterans with PTSD enrolled in collaborative care, patients were categorized into four mutually exclusive TFP groups: TFP not discussed; TFP discussed, declined; TFP discussed, did not decline; and TFP initiated. We conducted semistructured interviews with 43 unique patients and 58 unique providers (i.e., care managers and mental health specialists). Almost half (48.6%) of the veterans had no documentation of discussing TFP with their care manager; another 28.9% discussed it but declined. Most veterans (77.1%) had an encounter with a mental health specialist, 36.8% of whom never discussed TFP, and 35.7% of whom discussed it but declined. Providers reported that many veterans were not able, willing, or ready to engage in TFP and that non–trauma‐focused therapies were better aligned with their treatment goals. Veterans gave numerous reasons for not initiating TFP, including having bad prior experiences with TFP and wanting to avoid thinking about past traumatic experiences.Commonly cited reasons for noninitiation were providers never discussing TFP with veterans and veterans declining TFP after discussing it with their provider. Interventions, such as shared decision‐making tools, may be needed to engage providers and patients in informed discussions about TFP.
Secretive marsh bird occupancy across a spectrum of hydroelectric reservoir management in western montane Canada
Authors: Westphal Ashleigh M. , Green David J. , Arndt Janice E. , Darvill Rachel , Drever Mark C. 
Published: June 2023

AbstractDam construction projects have created opportunities for water security, targeted flood protection, and energy production but at the cost of increasing anthropogenic pressure on affected aquatic ecosystems. Wetland ecosystems are often among the most vulnerable, as underlying hydrological regimes influence overall wetland structure and function. Marsh bird species are wetland and riparian habitat specialists, many of which are experiencing population declines across North America. We examined how the alteration of hydrological regimes for generating hydroelectric power affected the occurrence of secretive marsh bird species in the western montane region of British Columbia, Canada. We established survey stations in wetlands across 2 regions, the West Kootenay and the Columbia Wetlands, sampling across a spectrum of hydrological regimes and other potentially relevant factors. At each station, we assessed wetland occupancy during the breeding season using broadcast‐callback surveys focused on 5 secretive marsh bird species: American bittern (Botaurus lentiginosus), American coot (Fulica americana), pied‐billed grebe (Podilymbus podiceps), sora (Porzana carolina), and Virginia rail (Rallus limicola). Additionally, we measured vegetation structure and the proximity and size of nearby water bodies for each survey station. We then used occupancy models to assess important correlates behind wetland occupancy for these marsh bird species, considering water management operations, regional differences, and local‐ and landscape‐level wetland characteristics. Secretive marsh bird species were more likely to occupy wetlands in areas with less frequently altered hydrological regimes. Occupancy models highlighted local‐ and landscape‐level characteristics as important correlates for wetland occupancy by marsh birds. Wetlands with frequently altered hydrological regimes had more open water cover and less tall vegetation present, conditions that were negatively associated with occupancy. Altered wetlands in this study were farther from the next nearest wetland, which was also negatively associated with occupancy. We suggest reservoir management is altering vegetation communities within these wetlands, indirectly promoting lower occupancy of secretive marsh bird species.
Electrospun Polyacrylonitrile/Polyvinylidene Fluoride/Boehmite Separator and Gel Polymer Electrolyte Polyethylene Oxide/Polyvinylidene Fluoride‐hexafluoropropylene/Lithium Bis(trifluoromethanesulfonyl)imide/Boehmite Composite Separator Are Used for Fast Charging
Authors: Tan Haowen , Jia Shaojin 
Published: June 2023

AbstractWith the increasing popularity of electric vehicles, the fast charging of lithium (Li) batteries is attracting increasing attention. However, the rapid decline in battery capacity caused by fast charging and accidents caused by Li dendrites piercing the separator greatly restrict fast‐charging applications. Herein, an electrospun polyacrylonitrile/polyvinylidene fluoride/boehmite (PAN/PVDF/12 wt.% AlO(OH)) and gel polymer polyethylene oxide/polyvinylidene fluoride‐hexafluoropropylene/lithium bis(trifluoromethanesulfonyl)imide/boehmite (PEO/PVDF‐HFP/12.6 wt.% LiTFSI /10 wt.% AlO(OH)) pressed together to form a two‐layer functional separator is designed. The electrospun separator improves the high‐temperature resistance of the entire separator due to its special structure. After the 1 h heat treatment at 220 °C, the thermal shrinkage rate of the double‐layer separator reaches 10.1%, showing good thermal stability. At 0.2 C, the discharge capacity retention rate is 99.4% after 100 cycles. After 1000 cycles at a rate of 10 C, the discharge capacity remains at 88% of the initial value. The two‐layer separator exhibits better capacity retention and superior rate performance than PP, providing an effective approach for commercializing fast‐charging functional separators.
The reconfiguration pattern of individual brain metabolic connectome for Parkinson's disease identification
Authors: Li Weikai , Tang Yongxiang , Peng Liling , Wang Zhengxia , Hu Shuo , Gao Xin 
Published: June 2023

Abstract18F‐Fluorodeoxyglucose positron emission tomography (18F‐FDG PET) is widely employed to reveal metabolic abnormalities linked to Parkinson's disease (PD) at a systemic level. However, the individual metabolic connectome details with PD based on 18F‐FDG PET remain largely unknown. To alleviate this issue, we derived a novel brain network estimation method for individual metabolic connectome, that is, Jensen‐Shannon Divergence Similarity Estimation (JSSE). Further, intergroup difference between the individual's metabolic brain network and its global/local graph metrics was analyzed to investigate the metabolic connectome's alterations. To further improve the PD diagnosis performance, multiple kernel support vector machine (MKSVM) is conducted for identifying PD from normal control (NC), which combines both topological metrics and connection. Resultantly, PD individuals showed higher nodal topological properties (including assortativity, modularity score, and characteristic path length) than NC individuals, whereas global efficiency and synchronization were lower. Moreover, 45 most significant connections were affected. Further, consensus connections in occipital, parietal, and frontal regions were decrease in PD while increase in subcortical, temporal, and prefrontal regions. The abnormal metabolic network measurements depicted an ideal classification in identifying PD of NC with an accuracy up to 91.84%. The JSSE method identified the individual‐level metabolic connectome of 18F‐FDG PET, providing more dimensional and systematic mechanism insights for PD.
Amantadine‐Induced Craniofacial Myoclonus: Distinctive Iatrogenic Dysarthria in Parkinson's Disease
Authors: Lin Iris , Armengou‐Garcia Laura , Sasikumar Sanskriti , Kuhlman Greg , Fox Susan H. , Lang Anthony E. , Espay Alberto J. 
Published: June 2023

ABSTRACTBackgroundAmantadine is a widely prescribed medication in Parkinson's disease (PD). A distinctive craniofacial distribution of myoclonus with speech impairment is an underrecognized iatrogenic complication in amantadine‐treated patients with PD.CasesWe report 7 patients with idiopathic PD (disease duration, 6–21 years) who developed speech‐induced craniofacial‐predominant myoclonus with “stuttering‐like” dysarthria and speech arrests days to months after amantadine initiation or dose increase. Renal insufficiency was identified as a risk factor in 4 cases. In all cases, reduction or discontinuation of amantadine markedly attenuated the myoclonus and restored speech intelligibility.Literature ReviewAmantadine can induce subcortical segmental or generalized myoclonus. A report in 1996 of “vocal myoclonus” in an amantadine‐treated patient with PD was the first observation of a focal distribution of myoclonus, particularly affecting speech. Since then, few cases of craniofacial myoclonus with speech impairment have been reported, none with accompanying video. With 1 exception, the craniofacial distribution was part of a generalized pattern of amantadine‐induced myoclonus. Comorbid renal insufficiency is a recognized risk factor.ConclusionsSpeech‐induced craniofacial myoclonus, with marked “stuttering‐like” dysarthria and speech arrests, is a disabling iatrogenic complication in PD that resolves upon amantadine discontinuation.