bluuebunny/crossref_metadata_2025_split huggingface dataset:
Corruzione fra privati nel settore immobiliare - il «caso poco grave»
Authors: Teichmann Fabian , Gaffuri Dimitri 
Published: September 2023

Sulla base di un esempio, gli autori trattano del fenomeno della corruzione fra privati (art. 322octies seg. CP) sul mercato immobiliare. In particolare, sono messe in risalto le problematicità legate all'art. 322octies cpv. 2 rispettivamente all'art. 322novies cpv. 2 CP, secondo cui il reato è perseguibile solo a querela di parte nei casi poco gravi. Tale distinzione, che costituisce un unicum all'interno del diritto penale svizzero, può portare a situazioni in cui la corruzione fra privati risulta punibile ai sensi di altre norme del Codice penale, ma non della normativa specifica.
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Sur la base d'un exemple, les auteurs traitent du phénomène de la corruption privée (art. 322octies ss CP) sur le marché de l'immobilier. Ils soulignent en particulier les problèmes liés à l'art. 322octies al. 2 et art. 322novies al. 2 CP, selon lesquels l'infraction n'est poursuivie que sur plainte dans les cas de peu de gravité. Cette distinction, unique en droit pénal suisse, peut conduire à des situations où la corruption privée est certes punie par les dispositions relatives aux infractions contre le patrimoine, mais pas par les art. 322octies ss CP pourtant prévus à cet effet.
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Auf Grundlage eines Beispiels erörtern die Autoren das Phänomen der Privatbestechung (Art. 322octiesff. StGB) im Immobiliensektor. Sie beleuchten insbesondere die Problematik, die daraus ensteht, dass das Delikt in einfachen Fällen nur auf Antrag verfolgt wird. Diese im schweizerischen Strafrecht einmalige Konstellation kann dazu führen, dass eine Bestechung zwischen Privatpersonen zwar nach den Bestimmungen des Vermögensstrafrechts strafbar ist, nicht aber nach den eigentlich dafür vorgesehenen korrputionsstrafrechtlichen Art. 322octiesff. StGB.
β-cyclodextrin Mediated Green Synthesis of Bioactive Heterocycles
Authors: Tayade Yogesh Ashok , Wagh Yogesh Baburav , Dalal Dipak Sharadrao 
Published: September 2023

Abstract:
In this review, we report β-cyclodextrin catalyzed green transformations of biologically
active heterocycles. β-Cyclodextrin is a seminatural product, water-soluble, highly efficient, and biodegradable
catalyst. β-Cyclodextrin is a versatile catalyst and promotes a variety of multicomponent
transformations, biomimetic reactions, C-C bond formation, and synthesis of some biologically
active natural products. It has been applicable to attain some name reactions, deprotection
of THP/MOM/Ac/Ts ethers, oxidative cleavage of epoxides, oxidative dehydrogenation of alcohol,
regioselective cyclization of chalcone epoxides and 2’-aminochalcones. The catalyst is useful to carry
out diastereoselective reactions, and it also plays a very important role in phase transfer catalysts.
Efficacy of Herbal Medicine in Hand Osteoarthritis: A Narrative Review
Authors: Aghili Seyedeh Mehrnaz , Sahebari Maryam , Salari Masoumeh , Noorabadi Parisa 
Published: September 2023

Objective:
Osteoarthritis (OA) is one of the most prevalent joint disorders in the world
that has placed an enormous economic and social burden on governments and healthcare sectors in
many countries. Hand OA (HOA) is the most common peripheral arthritis, which is less investigated
than knee and hip OA. Due to limited approved drug choices and adverse effects of long-term
use of current regimens, we aimed to review the existing evidence that were used as oral herbal
medicine to treat HOA.

Methods:
The PubMed database was searched for both observational and interventional studies
that have investigated herbal medicine safety and efficacy in HOA, written in English and published
between 2010 and 2022.

Results:
A total of 5 original articles fulfilled the inclusion criteria, and each article assessed a different
herbal regimen. Overall, it seems desirable to add specific herbal treatments to the regimen
of HOA patients, specifically in case of early stages of HOA.

Conclusion:
Currently, the need for a low-risk alternative treatment in HOA patients is felt more
than ever. There are reliable references relating to the safety of Korean red ginseng, GCSB-5, XLGB,
and GS-GCu in these patients, although their efficacy was limited. Additionally, herbs like curcumin
and Boswellia serrata have positively affected patients with knee osteoarthritis. However,
there is a lack of strong evidence supporting their effectiveness in hand osteoarthritis (HOA). This
emphasizes the potential benefits that these herbs may have for HOA patients.
Comparison of Imaging Characteristics of Gangliogliomas between
Child/Adolescent Group and Adult Group
Authors: Zheng Xuan , Huang Quan , Guo Shao-Lei , Zou Meng-Sha , Zhu Hui , Li Shi-Ting 
Published: September 2023

Background:
Ganglioglioma is a rare, slowly proliferating mixed glioneuronal tumor, with the highest incidence observed in children and young adults, but it
can also occur in adults.

Objective:
This study aimed to compare the imaging characteristics of ganglioglioma in children/adolescents and adults to facilitate radiographic diagnosis.

Methods:
In this retrospective study, a total of 32 patients were included and divided into two groups: the child/adolescent group (age < 18 years, n=19) and
the adult group (age ≥ 18 years, n=13). Various variables were analyzed, including maximum diameter, location, periphery, border, calcification,
unenhanced CT attenuation, T1WI, T2WI/FLAIR, and DWI signal intensity, enhancement pattern, degree of enhancement, homogeneity of
enhancement, solid/cystic component, peri-tumoral edema, intra-tumoral septa, peri-tumoral capsule, and intra-tumoral hemorrhage.

Results:
Most gangliogliomas were situated in the peripheral regions, particularly in the temporal lobe. The majority exhibited hypointense/isointense
signals on T1WI and hyperintense signals on T2WI/FLAIR and DWI, with predominantly heterogeneous nodular enhancement. Peri-tumoral
edema was significantly less frequent in the child/adolescent group, while marked enhancement was significantly more common in the adult group.
There was no significant difference in maximum diameter between the child/adolescent group and the adult group.

Conclusion:
Peri-tumoral edema was significantly less prevalent in the child/adolescent group, whereas marked enhancement was significantly more frequent in
the adult group. To ensure accurate results, a larger case series should be conducted to validate our findings.
Assessment of Apparent Diffusion Coefficient Parameters and Coefficient of
Variance in Discrimination of Receptor Status and Molecular Subtypes of
Breast Cancer
Authors: Ozkul Ozlem , Sever Ibrahim , Ozkul Bahattin 
Published: September 2023

Objective:
The objective of this study was to investigate the diagnostic power of apparent diffusion coefficient/coefficient of variance (ADCcV) as well as ADC parameters formed based on magnetic resonance images (MRI) in the distinction of molecular breast cancer subtypes.

Methods:
The study involved 205 patients who had breast cancer at stages 1-3. Estrogen receptor (EsR), progesterone receptor (PrR), human epidermal growth factor receptor 2 (Her2), and proliferation index (Ki-67) were histologically analyzed in the tumor. The correlations between the immunohistochemistry and intrinsic subtypes were analyzed using ADC and ADCcV.

Results:
The maximum whole tumor (WTu) ADC (p=0.004), minimum WTu ADC (p<0.001), and mean WTu ADC (p<0.001) values were significantly smaller in the EsR-positive tumors than those in the EsR-negative tumors. Compared to the PrR-negative tumors, the PrR-positive tumors showed significantly smaller maximum, minimum, and mean WTu ADC values (p=0.005, p=0.001, and p<0.001, respectively). In the comparisons of the molecular subtypes in terms of ADCcV, the p-values indicated statistically significant differences between the luminal A (lumA) group and the triple negative (TN) group, between the luminal B (lumB) group and the TN group, and between the Her2-enriched and TN groups (p<0.001, p=0.011, and p=0.004, respectively). Considering the luminal and non-luminal groups, while a significant difference was observed between the groups considering their minimum, maximum, and mean WTu ADC values, their ADCcV values were similar (p<0.001, p=0.004, and p<0.001, respectively).

Conclusion:
Using ADCcV in addition to ADC parameters increased the diagnostic power of diffusion weighted-MRI (DW-MRI) in the distinction of molecular subtypes of breast cancer.
A Systematic Review and Meta-Analysis of the Metal Nano-Particles Loaded with Herbal Drugs Moieties Against Breast Cancer
Authors: Nishal Suchitra , Kumar Virender , Phaugat Parmita , Kumar Davinder , Khatri Naveen , Singh Gajendra 
Published: September 2023

Background:
Breast cancer is the most prevalent cancer among women. About 685K deaths
were globally listed in 2020 by the World Health Organization. Nowadays, scientists prefer to use herbal
medicines due to their low toxicity. Herbal medicines are used to overcome the toxicity effects of
surgical removal, radio-chemo therapy and medication, which have a lot of risk of damaging the healthy
tissues. To overcome this, enhance bioavailability and target specify, nano-formulation chemotherapy
was introduced using herbal moiety for anticancer activity. The use of metallic nanoparticles (MNPs),
particularly those made of silver, cobalt, zinc, and gold as contrast, antibacterial, anticancer, and drug
delivery agents has revolutionised the medicinal field. Although MNPs can be made via exacting physical
and chemical processes, a biological method utilising natural materials has been established recently.

Objectives:
This review article will offer a succinct explanation of the use of MNPs and its potential
impact on herbal medicines in the future.

Methods:
Using PRISMA principles, this review systematically examines studies that concentrate on metal nanoparticles loaded with herbal compounds for the treatment of breast cancer. Various Databases were studied: PubMed, Elsevier, ScienceDirect, SpringerLink, Taylor & Francis Online, ACS Publications, Publishing Royal Society of Chemistry, and Future Medicines. Studies were selected if they were peer-reviewed primary studies published in the past 10 years.

Results:
We found that many herbal nano-formulations are more effective in breast cancer treatment than other types of formulations. Efficacy, safety and drug stability are also enhanced using nano-formulations.

Conclusion:
Nano-formulation is found to be more effective in the treatment of breast cancer.
Patient Perceptions with Virtual Family Medicine Clinics in the Eastern Province of Saudi Arabia
Authors: Alsubaie Hajer Adel , Bugis Bussma Ahmed 
Published: September 2023

Background:
With the growth of technology and with many people having access to the internet, there has been an increasing trend of many people embracing telemedicine and virtual clinics. In Saudi Arabia, there is limited data and information about the perceptions of the patients regarding virtual clinics, especially for family medicine virtual care.

Objective:
This study was conducted to fill this gap by determining the patients’ perceptions of family medicine virtual clinics in Saudi Arabia.

Methods:
The study was a cross-sectional descriptive study. This study employed the use of a survey approach to evaluate the patient's perceptions of family medicine virtual care in the Eastern Province of Saudi Arabia. The targeted population was the adult patients who used family medicine virtual services in 2021.

Results:
The study population was 395 participants. The plurality of respondents (38.50%) had rated their previous use of virtual family medicine as very good, and 44.60% have experienced an improvement in their health, 46.60% received enough information, and 49.10% felt that their privacy was respected.

Conclusion:
In Saudi Arabia, virtual clinics seem to be increasing in terms of popularity, and different approaches have been used in different conditions and specialties. Virtual family medicine services need improvement for enhanced adoption. Home health management, protecting patient privacy, and improvements in technical requirements would enhance patient experience with virtual family medicine services for many patients in the Eastern Province of Saudi Arabia.
Exploring potentials of Electuaries for Controlling Chronic Respiratory
Diseases in Unani Medicine: A Systematic Review
Authors: Khan Muzayyana , Akhlaq Shaheen , Shamsi Shariq 
Published: September 2023

Background:
Chronic respiratory diseases rate has been increasing alarmingly, causing huge burden on the mortality and morbidity. Environmental pollution and occupational exposure, the major identified risk factors and endless adverse effects of conventional medicine put forward the need for better alternative options. Electuaries are the pharmaceutical formulation of poly herbal drugs that are employed as effective remedy for respiratory disorders in Unani system of medicine.

Objective:
The aim is to assess the effectiveness of Unani pharmaco-therapeutics in the management of various respiratory diseases and the computation of drug/water and drug/sugar ratio for the elaborated electuaries.

Methods:
A web-based review on certain selected Unani drugs and its molecular mechanism was carried out using the data bases such as Pub Med, Google Scholar, Science Direct and Scopus published until the end of June 2022.

Results:
It was observed that several single drugs such as Khayarshambar (Cassia fistula L.), Sapistan (Cordia dichotama Forst), Asl-us- Soos (Glycyrrhiza glabra L.), Khatmi (Althea officianialis L.), Za’fran (Crocus sativus L.), Behīdāna (Cydonia oblonga Mill.) etc. used in Unani formulations claimed to be effective in management of respiratory diseases like COVID 19. The herbs and its chemical constituents showed the preventive effect on respiratory diseases with inflammatory cell mediators, lung pathologies, airway response and immunomodulatory effects. The results of research studies (preclinical, clinical or in silico) and their molecular mechanisms on Electuaries have proved to be optimal for the respiratory system.

Conclusion:
Unani poly-pharmaceutics showed anti-inflammatory, anti-viral, anti-bacterial, anti-allergic, anti- tussive, mucolytic actions arresting respiratory diseases.
Comparison of the efficiency of the remote approaches for analgesia after total hip arthroplasty
Authors: Gavrykov O.Y. , Kupin V.I. , Kolomachenko V.I. 
Published: September 2023

Background. Recently, two blocks have been proposed: one of which is the most proximal and is called the erector spinae plane (ESP) block, the other is the most distal and is called pericapsular nerve group (PENG) block. Both techniques are performed under ultrasound control, are positioned as effective and safe, without muscle weakness. The purpose of the work: to evaluate the clinical effectiveness of the most remote approaches (ESP and PENG) for anesthesia in terms of the adequacy of analgesia and physical activity of patients after hip arthroplasty. Materials and methods. The study included 70 ASA II–III patients: 40 women and 30 men with an average age of 64.6 ± 10.7 years who underwent planned primary total hip arthroplasty for disease or fracture under spinal anesthesia. After the surgery, ESP block was performed in group I (n = 35), PENG block in group II (n = 35), 30 ml of 0.25% bupivacaine solution was injected. The ability to cover a distance of 30 meters without time limits, the maximum severity of the pain syndrome, the need for opioids (nalbuphine), the duration of the block and the number of patients with postoperative complications were evaluated. Results. The duration of PENG block was on average 8.6 (5.6–9.8) hours, which statistically significantly exceeded this indicator in patients who received ESP block with an average duration of 5 (3.8–6.0) hours (p < 0.001). With comparable analgesia in both groups, patients who received PENG block required less time to walk the 30-meter distance — 31.0 (27.0–47.0) hours compared to those who received ESP block — 45.0 (32.0–54.0) hours (p = 0.006). In group II, 28.6 % of patients did not need opioids in the postoperative period, and this indicator in group I was only 8.5 % (p = 0.036), demonstrating the better analgesic potential of PENG block. Conclusions. Given the ease of implementation and safety of both regional methods, as well as the effectiveness of PENG block, it appears to be a real alternative to other regional methods in this category of patients.
Spatial Distribution of Groundwater Salinity In The Coastal Area of Aceh Besar District
Authors: Kalbadri Muhammad , Ramli Ichwana , Faisal Muhammad 
Published: September 2023

Abstract: Utilization of groundwater sources is still an alternative for people living in the coastal areas of Aceh Besar District. If the use of groundwater is carried out continuously, it will have a negative impact on the quality and quantity of groundwater. So the purpose of this study was to determine the distribution of groundwater salinity in the coastal areas of Aceh Besar District. The sample points were determined based on the random sampling method in grids. Sample testing for groundwater salinity was carried out directly in the field according to the planned location. The data obtained was inputted into Microsoft excel and mapping of groundwater salinity distribution using the Inverse Distance Weight (IDW) method with Argis software. A correlation test was performed with Pearson Product Moment. Based on the measurement results, 20 sample points of high salinity were measured. The distribution of salinity values also has a relationship with coastal distance, where the distribution of salinity in general, the farther the groundwater is from the coast, the lower the salinity value, and the closer the groundwater to the coast, the higher the salinity.Abstrak: Pemanfaatan sumber air tanah masih menjadi alternatif bagi masyarakat yang tinggal di wilayah pesisir Kabupaten Aceh Besar. Jika pemanfaatan air tanah dilakukan secara terus-menerus akan berdampak negatif secara kualitas dan kuantitas air tanah. Sehingga tujuan penelitian ini adalah untuk mengetahui sebaran salinitas air tanah di wilayah pesisir Kabupaten Aceh Besar. Titik sampel ditentukan berdasarkan metode random sampling in grids. Pengujian sampel untuk salinitas air tanah dilakukan langsung di lapangan sesuai dengan lokasi yang telah direncanakan. Data yang diperoleh diinput ke dalam Microsoft excel dan pemetaan distribusi salinitas air tanah menggunakan metode Inverse Distance Weight (IDW) dengan perangkat lunak Argis. Uji korelasi dilakukan dengan Pearson Product Moment. Berdasarkan hasil pengukuran, nilai salinitas yang tinggi terukur sebanyak 20 titik sampel. Nilai salinitas tinggi pada umumnya dipengaruhi oleh intrusi air asin terhadap air tawar. Faktor sebaran salinitas air tanah terjadi akibat intrusi, penggunaan lahan yang dekat dengan tambak dan muara sungai, faktor sebaran salinitas juga dipengaruhi oleh kepadatan penduduk. Sebaran nilai salinitas juga memiliki hubungan dengan jarak pantai, dimana sebaran salinitas secara umum, semakin jauh air tanah dengan jarak pantai maka nilai salinitasnya semakin rendah, dan semakin dekat air tanah dengan jarak pantai maka salinitasnya semakin tinggi.
Effluent Quality Test On The Communal WWTP in Banda Aceh City
Authors: Muslimin Ikhwanul , Machdar Izarul , Arahman Nasrul 
Published: September 2023

Abstract: One of the domestic wastewater management systems developed in Banda Aceh City is a settlement-scale centralized wastewater treatment plant, also known as the Communal WWTP system, with an anaerobic baffled reactor (ABR) and anaerobic filter (AF) configuration. This study aims to examine the quality of the effluent from the treatment of communal WWTPs in the city of Banda Aceh. Measurements of the contents of pH, BOD, COD, TSS, Ammonia, and Total Coliform were carried out on effluent samples from the communal WWTP and the results of the analysis were compared with the quality standards from the Minister of Environment and Forestry Regulation No. 68 of 2016 concerning Domestic Wastewater Quality Standards. The research showed that the pH, COD, BOD, and Ammonia parameters had met the quality standards, while the TSS and Total Coliform parameters at the five (5) locations of the communal WWTP studied had not shown effective performance and had not met the quality standards. The choice of technology configuration and management of communal WWTP is a factor that influences the processing performance and quality of communal WWTP effluent in Banda Aceh City.Abstrak: Salah satu sistem pengelolaan air limbah domestik yang dikembangkan di Kota Banda Aceh adalah SPALD-Terpusat skala permukiman, atau disebut juga dengan sistem IPAL Komunal, dengan konfigurasi anaerobic baffled reactor (ABR) dan anaerobic filter (AF). Penelitian ini bertujuan untuk menguji kualitas efluen hasil pengolahan IPAL komunal yang ada di kota Banda Aceh. Pengukuran kandungan pH, BOD, COD, TSS, Amonia serta Total Coliform dilakukan pada sampel efluen dari IPAL komunal dan hasil analisisnya dibandingkan dengan baku mutu Peraturan Menteri Lingkungan Hidup dan Kehutanan No. 68 Tahun 2016 tentang Baku Mutu Air Limbah Domestik. Penelitian menunjukkan parameter pH, COD, BOD dan Amonia telah memenuhi baku mutu sedangkan parameter TSS dan Total Coliform pada lima (5) lokasi IPAL komunal yang diteliti belum menunjukkan kinerja yang efektif dan belum memenuhi standar baku mutu. Pemilihan konfigurasi teknologi dan pengelolaan IPAL komunal menjadi faktor yang mempengaruhi kinerja pengolahan dan kualitas efluen IPAL komunal di Kota Banda Aceh.