bluuebunny/crossref_metadata_2025_split huggingface dataset:
Role of personal aptitudes as determinants of incident morbidity, lifestyles, quality of life, use of the health services and mortality (DESVELA cohort): qualitative study protocol for a prospective cohort study in a hybrid analysis
Authors: Young-Silva Yudy , Berenguera Anna , Jacques-Aviñó Constanza , Gil-Girbau Montserrat , Arroyo-Uriarte Paula , Chela-Alvarez Xenia , Ripoll Joana , Martí-Lluch Ruth , Ramos Rafel , Elizondo-Alzola Usue , Garcia-Martinez Sandra , Méndez-López Fátima , Tamayo-Morales Olaya , Martínez-Andrés Mária , Motrico Emma , Gómez-Gómez Irene , Fernández-Alvarez Roberto , Juvinyà-Canal Dolors ,   the DESVELA Cohort investigators
Published: June 2023

IntroductionMaintaining or acquiring healthier health-oriented behaviours and promoting physical and mental health amongst the Spanish population is a significant challenge for Primary Health Care. Although the role of personal aptitudes (characteristics of each individual) in influencing health behaviours is not yet clear, these factors, in conjunction with social determinants such as gender and social class, can create axes of social inequity that affect individuals’ opportunities to engage in health-oriented behaviours. Additionally, lack of access to health-related resources and opportunities can further exacerbate the issue for individuals with healthy personal aptitudes. Therefore, it is crucial to investigate the relationship between personal aptitudes and health behaviours, as well as their impact on health equity.ObjectivesThis paper outlines the development, design and rationale of a descriptive qualitative study that explores in a novel way the views and experiences on the relationship between personal aptitudes (activation, health literacy and personality traits) and their perception of health, health-oriented behaviours, quality of life and current health status.Method and analysisThis qualitative research is carried out from a phenomenological perspective. Participants will be between 35 and 74 years of age, will be recruited in Primary Health Care Centres throughout Spain from a more extensive study called DESVELA Cohort. Theoretical sampling will be carried out. Data will be collected through video and audio recording of 16 focus groups in total, which are planned to be held in 8 different Autonomous Communities, and finally transcribed for a triangulated thematic analysis supported by the Atlas-ti program.DiscussionWe consider it essential to understand the interaction between health-related behaviours as predictors of lifestyles in the population, so this study will delve into a subset of issues related to personality traits, activation and health literacy.Clinical trial registration: ClinicalTrials.gov, identifier NCT04386135.
Health-related quality of life of children with Williams syndrome and caregivers in China
Authors: Chen Weijun , Sun Lidan , He Xinyu , Li Ziqiao , Ji Chai , Li Fangfang , Shen Jiyang , Pan Tianxin , Jin Xuejing , Dong Yusang , Hu Lidan , Zou Chaochun , Bai Guannan 
Published: June 2023

IntroductionWilliams syndrome (WS) is a rare genetic disorder that impacts multiple systems and may cause developmental delays. These medical and developmental issues impose a heavy burden on affected children and their families. However, there was no study on children’s health-related quality of life (HRQoL) with WS and only two studies about family quality of life globally. Therefore, the primary purpose of this study was to assess the HRQoL of children with WS and their caregivers in China, and the secondary purpose was to identify the potential determinants of children’s and caregivers’ HRQoL.MethodsIn total, 101 children and caregivers were included. We applied the proxy-reported PedsQL 4.0 Generic Core Module (PedsQL GCM) and PedsQL 3.0 Family Impact Module (FIM) to measure the HRQoL of children and caregivers. Additionally, we collected information on a comprehensive set of social demographic and clinical characteristics. Differences in HRQoL scores across subgroups were assessed by two-independent-samples t-tests, one-way ANOVA, and post hoc tests. We also calculated effect sizes to indicate clinical relevance. Multivariate linear regression models were applied to assess the potential determinants of HRQoL.ResultsWe found that the HRQoL of children with WS and their caregivers was dramatically worse than the norm average scores of the healthy controls of children published in previous studies. Paternal educational level, household income, and the perceived financial burden significantly influenced the HRQoL of both children and families (p-values &lt; 0.05). Multivariate linear regression analysis showed that the perceived financial burden was independently associated with family quality of life (p-values &lt; 0.05)., and the presence of sleeping problem was independently associated with children’s HRQoL (p-value = 0.01).ConclusionWe call for attention from policymakers and other stakeholders on the health status and well-being of children with WS and their families. Supports are needed to relieve psychosocial distress and financial burden.
Drinking water contamination potential and associated factors among households with under-five children in rural areas of Dessie Zuria District, Northeast Ethiopia
Authors: Berihun Gete , Abebe Masresha , Hassen Seada , Gizeyatu Adinew , Berhanu Leykun , Teshome Daniel , Walle Zebader , Desye Belay , Sewunet Birhanu , Keleb Awoke 
Published: June 2023

ObjectiveMore than half of the 700 million people worldwide who lack access to a safe water supply live in sub-Saharan Africa, including Ethiopia. Globally, approximately 2 billion people use drinking water sources that are contaminated with fecal matter. However, little is known about the relationship between fecal coliforms and determinants in drinking water. Therefore, the objective of this study was to investigate the potential for contamination of drinking water and its associated factors in households with children under 5 years of age in Dessie Zuria district in northeastern Ethiopia.MethodsThe water laboratory was conducted based on the American Public Health Association guidelines for water and wastewater assessment using a membrane filtration technique. A structured and pre-tested questionnaire was used to identify factors associated with the potential for contamination of drinking water in 412 selected households. A binary logistic regression analysis was performed to determine the factors associated with the presence or absence of fecal coliforms in drinking water, with a 95% confidence interval (CI) and a value ofp ≤ 0.05. The overall goodness of the model was tested using the Hosmer-Lemeshow test, and the model was fit.ResultsA total of 241 (58.5%) households relied on unimproved water supply sources. In addition, approximately two-thirds 272 (66.0%) of the household water samples were positive for fecal coliform bacteria. Water storage duration ≥3 days (AOR = 4.632; 95% CI: 1.529–14.034), dipping method of water withdrawal from a water storage tank (AOR = 4.377; 95% CI: 1.382–7.171), uncovered water storage tank at control (AOR = 5.700; 95% CI: 2.017–31.189), lack of home-based water treatment (AOR = 4.822; 95% CI: 1.730–13.442), and unsafe household liquid waste disposal methods (AOR = 3.066; 95% CI: 1.706–8.735) were factors significantly associated with the presence of fecal contamination in drinking water.ConclusionFecal contamination of water was high. The duration of water storage, the method of water withdrawal from the storage container, covering of the water storage container, the presence of home-based water treatment, and the method of liquid waste disposal were factors for fecal contamination in drinking water. Therefore, health professionals should continuously educate the public on proper water use and water quality assessment.
Comparison of Two Versus Three Bilateral Botulinum Toxin Injections Prior to Abdominal Wall Reconstruction
Authors: Timmer Allard S. , Ibrahim Faduma , Claessen Jeroen J. M. , Aehling Carolin J. , Kemper Tom C. P. M. , Rutten Martin V. H. , Boermeester Marja A. 
Published: June 2023

Background: Intramuscular injection of botulinum toxin A (BTA) induces a temporary muscle paralysis. In patients with a ventral hernia, preoperative injection of BTA in the muscles of the lateral abdominal wall (LAW) leads to thinning and lengthening of these muscles, making fascial closure more likely. In many hernia centres, treatment with BTA prior to abdominal wall reconstruction has therefore become standard care. However, evidence on the optimal BTA strategy is lacking.Methods: In this single-centre retrospective study, we analysed a consecutive cohort of ventral hernia patients that underwent bilateral BTA injections prior to abdominal wall reconstruction with available CT before and after BTA. We only included patients that were treated with exactly 600 units of Dysport®, diluted into 120 mL of saline, via either two- or three injections on each side into all three LAW muscle layers. The primary outcome was the change in LAW muscle length and thickness, comparing CT measures from before BTA and 4–6 weeks after the injections.Results: We analysed 67 patients; 30 had received two injections bilaterally and 37 had received three injections bilaterally. Baseline data showed no significant differences in LAW muscle thickness or length between groups. In both groups, the median LAW muscle thickness decreased with 0.5 cm (p &lt; 0.001). The LAW muscle length increased with 0.9 cm (p = 0.001) and 1.2 cm (p &lt; 0.001) in the two- and three bilateral injection group, respectively. The BTA-induced changes in LAW thickness and length were not significantly different between both groups (p = 0.809 and p = 0.654, respectively).Discussion: When using the exact same dosage and distribution volume of BTA in patients with a complex abdominal wall defect, two injections bilaterally in the lateral abdominal wall muscles are as effective as three injections bilaterally.
Case Report: Brainstem angiocentric glioma presenting in a toddler child–diagnostic and therapeutic challenges
Authors: Reisz Zita , Radics Bence Laszlo , Nemes Peter , Laxton Ross , Kaizer Laszlo , Gabor Krisztina Mita , Novak Timea , Barzo Pal , Al-Sarraj Safa , Bodi Istvan 
Published: June 2023

Introduction: Angiocentric gliomas (AG) in brainstem location are exceedingly rare and might cause differential diagnostic problems and uncertainty regarding the best therapeutic approach. Hereby, we describe the clinicopathological findings in a brainstem AG presenting in a toddler child and review the literature.Case report: A 2-year-old boy presented with 5 weeks history of gait disturbances, frequent falls, left-sided torticollis and swallowing problems. MRI head showed a T2-hyperintense, partly exophytic mass lesion centred in the pontomedullary region, raising the possibility of diffuse midline glioma. The exophytic component was partially resected by suboccipital craniotomy, leaving intact the infiltrative component. Ventriculoperitoneal shunt was implanted due to postoperative hydrocephalus. Histological examination revealed a moderately cellular tumour consisted of bland glial cells infiltrating the brain parenchyma and radially arranged around the blood vessels. By immunohistochemistry, the tumour strongly expressed S100 and GFAP in addition to intense nestin positivity, while OLIG2 was negative in the perivascular tumour cells. DNA methylation array profiled the tumour as “methylation class diffuse astrocytoma, MYB or MYBL1-altered subtype B (infratentorial)” and an in-frame MYB::QKI fusion was identified by RNA sequencing, confirming the diagnosis of angiocentric glioma. The patient has been initially treated with angiogenesis inhibitor and mTOR inhibitor, and now he is receiving palliative vinblastine. He is clinically stable on 9 months follow-up.Conclusion: Brainstem AG may cause a diagnostic problem, and the surgical and oncological management is challenging due to unresectability and lack of response to conventional chemo-radiation. In the future, genetically-tailored therapies might improve the prognosis.
Effects of Apatite Concentrate in Combination with Phosphate-Solubilizing Microorganisms on the Yield of Ryegrass Cultivar Izorskiy
Authors: Timofeeva Tatiana A. , Chebotar Vladimir K. , Demidov Dmitriy V. , Gaidukova Sofia E. , Yakovleva Irina V. , Kamionskaya Anastasia M. 
Published: June 2023

Soil microorganisms play a vital role in increasing the availability of phosphorus (P) for plants through mineralization of organic P and solubilization of precipitated P compounds. In this two-year study, we analyzed several P-solubilizing microorganisms (PSMs) of the genus Bacillus and their consortiums for the ability to release soluble P from apatite concentrates of various grinding degrees using ryegrass (Lolium multiflorum Lam.) as a model plant. The effects were accessed by analyzing plant growth and nutrient assimilation. The greatest effect on root system development and plant biomass accumulation (dry weight) was observed for the apatite concentrate of standard grinding in combination with Bacillus megaterium BI14 and Bacillus subtilis BI2 and Bacillus velezensis BS89 strains. Although the introduction of apatite concentrates led to an increase in the content of total strontium in soil, the levels of strontium did not exceed the maximum allowable concentration, and the accumulation of mobile strontium by plants was unchanged; importantly, the use of tested PSMs led to a decrease in the strontium content in the green biomass of ryegrass. Our results indicate that biologized apatite concentrates in combination with PSMs represent promising fertilizers that can provide a source of soluble P to be readily assimilated by plants.
Optical Characterization of Al Island Films: A Round Robin Test
Authors: Sancho-Parramon Jordi , Amochkina Tatiana , Wilbrandt Steffen , Kamble Hrishikesh , Janicki Vesna , Salamon Krešimir , Stenzel Olaf , Trubetskov Michael 
Published: June 2023

The determination of the effective optical constants of metal island films is an essential step towards the practical incorporation of this kind of films in optical coatings. In this work, the optical properties of aluminium island films deposited by electron beam evaporation on quartz substrates are investigated using different approaches employed by three research groups. The effective optical constants of the island films are inferred from optical measurements (spectrophotometry and spectroscopic ellipsometry) using: (i) a parameter-free dispersion model, (ii) a multiple oscillator model based on Gaussian line-shapes and (iii) the β distributed oscillator model. All the used approaches provide similar physical insights, i.e., an increase in the effective thickness of the metal island film, a red-shift and broadening of the plasmon resonance and an enhancement of the infrared absorption as the amount of deposited material increases. However, the optimal values of the effective optical constants and thickness significantly depend on the employed model and the experimental data used for data fitting.
Design, Synthesis, and Evaluation of the COX-2 Inhibitory Activities of New 1,3-Dihydro-2H-indolin-2-one Derivatives
Authors: Pan Taohua , He Maofei , Deng Lulu , Li Jiang , Fan Yanhua , Hao Xiaojiang , Mu Shuzhen 
Published: June 2023

Thirty-three 1,3-dihydro-2H-indolin-2-one derivatives bearing α, β-unsaturated ketones were designed and synthesized via the Knoevenagel condensation reaction. The cytotoxicity, in vitro anti-inflammatory ability, and in vitro COX-2 inhibitory activity of all the compounds were evaluated. Compounds 4a, 4e, 4i-4j, and 9d exhibited weak cytotoxicity and different degrees of inhibition against NO production in LPS-stimulated RAW 264.7 cells. The IC50 values of compounds 4a, 4i, and 4j were 17.81 ± 1.86 μM, 20.41 ± 1.61 μM, and 16.31 ± 0.35 μM, respectively. Compounds 4e and 9d showed better anti-inflammatory activity with IC50 values of 13.51 ± 0.48 μM and 10.03 ± 0.27 μM, respectively, which were lower than those of the positive control ammonium pyrrolidinedithiocarbamate (PDTC). Compounds 4e, 9h, and 9i showed good COX-2 inhibitory activities with IC50 values of 2.35 ± 0.04 µM, 2.422 ± 0.10 µM and 3.34 ± 0.05 µM, respectively. Moreover, the possible mechanism by which COX-2 recognized 4e, 9h, and 9i was predicted by molecular docking. The results of this research suggested that compounds 4e, 9h, and 9i might be new anti-inflammatory lead compounds for further optimization and evaluation.
Predictors of Gross Hematuria After SARS-CoV-2 mRNA Vaccination in Patients with IgA Nephropathy
Authors: Yokote Shinya , Tsuboi Nobuo , Shimizu Akihiro , Okabe Masahiro , Haruhara Kotaro , Sasaki Takaya , Ueda Hiroyuki , Yokoo Takashi 
Published: June 2023

Key Points

Little is known about the clinical characteristics of patients with immunoglobulin A nephropathy (IgAN) who present with gross hematuria in relation to SARS-CoV-2 mRNA vaccination.The relationship between the clinical features in patients with IgAN at the time of SARS-CoV-2 mRNA vaccination and the subsequent appearance of gross hematuria was investigated.This study demonstrates the clinical significance of microscopic hematuria in patients with IgAN as a predictor of gross hematuria after SARS-CoV-2 mRNA vaccination.

Background
There have been several reports of immunoglobulin A nephropathy (IgAN) patients with gross hematuria and acute deterioration of urinary findings and kidney function after severe acute respiratory syndrome coronavirus 2 mRNA vaccination. Recent case series studies have indicated a possible link between the status of urinary findings at the time of vaccination and the subsequent appearance of gross hematuria. In this study, we aimed to determine whether the status of prevaccination urinary findings was associated with postvaccination gross hematuria in patients already diagnosed with IgAN.

Methods
Outpatients with IgAN who had been followed up before vaccination were included. We analyzed the association between the remission of prevaccination microscopic hematuria (urine sediment <5 red blood cells/high-power field) or proteinuria (<0.3 g/gCr) and postvaccination gross hematuria.

Results
A total of 417 Japanese patients with IgAN (median age, 51 years; 56% female; eGFR, 58 ml/min per 1.73 m2) were included. The frequency of gross hematuria after vaccination was higher in 20 of 123 patients (16.3%) with microscopic hematuria than in 5 of 294 patients (1.7%) without microscopic hematuria before vaccination (P < 0.001). There was no association between prevaccination proteinuria and postvaccination gross hematuria. After adjusting for potential confounders, such as sex (female), age (younger than 50 years), eGFR (≥60 ml/min per 1.73 m2), and histories of tonsillectomy and corticosteroid therapy, prevaccination microscopic hematuria was still associated with postvaccination gross hematuria (odds ratio, 8.98; P < 0.001). As the severity of prevaccination microscopic hematuria increased, the incidence of postvaccination gross hematuria increased (P < 0.001).

Conclusions
Prevaccination microscopic hematuria in patients with IgAN is a major predictor of postvaccination gross hematuria, regardless of potential confounders, including previous treatments of IgAN.

Podcast
This article contains a podcast at https://dts.podtrac.com/redirect.mp3/www.asn-online.org/media/podcast/K360/2023_12_01_KID0000000000000192.mp3
PERAN GURU DALAM MOTIVASI BELAJAR PADA KETRAMPILAN BERBICARA SISWA KELAS I MATA PELAJARAN BAHASA INDONESIA DI SEKOLAH PENGGERAK SDN SUMBEREJO II
Authors: Siti Nur Janah  , Salsa Ayu Sabrina  , Isa Nur Fadhilah  , Fathimatuz Zahro  , Rizka Nur Oktaviani  
Published: June 2023

Dalam penelitian ini memiliki tujuan yakni untuk mengetahui peran guru dalam motivasi belajar dalam meningkatkan keterampilan berbicara siswa. Jenis metode yang dilakukan dalam penelitian ini adalah dengan menggunakan metode penelitian kualitatif. Metode penelitian ini adalah kualitatif dengan jenis penelitian kualitatif deskriptif. Adapun teknik pengumpulan data yang digunakan oleh peneliti adalah melalui observasi, wawancara, dan dokumentasi. Teknik analisis data yang digunakan oleh peneliti adalah data kualitatif dengan model Miles dan Huberman melalui beberapa aktivitas yakni pengumpulan data, reduksi data, penyajian data, dan verifikasi. Hasil penelitian mengenai peran guru dalam memotivasi siswa sangat berpengaruh terhadap ketrampilan berbicara siswa. Banyak hal yang dapat dilakukan seorang guru untuk memotivasi siswa diantaranya dengan menumbuhkan harapan dan cita-cita siswa. Guru selalu memotivasi siswa agar memiliki semangat belajar tinggi. Supaya siswa memiliki semangat belajar, guru tidak hanya memotivasi siswa akan tetapi guru juga harus memunculkan hasrat dan keinginan belajar siswa, memunculkan harapan dan cita-cita siswa, lalu memberikan penghargaan dalam belajar dengan mengambil strategi melalui pemberian apresiasi atau reward, serta adanya lingkungan belajar yang kondusif sehingga memungkinkan siswa dapat belajar dengan baik. Dengan ini siswa dapat terampil dalam berbicara serta tepat dalam pemilihan kata dan struktur kalimat yang logis
Parental Involvement in Learning Programs for Children with Special Needs in Indonesia
Authors: Muhaimi Mughni Prayogo  , Kristi Wardani  , Haniek Farida  
Published: June 2023

The practice of education in schools still needs to improve in the form of limited studies focusing on parental involvement in the learning process of children with special needs in Indonesia. This study aimed to identify the forms of parental involvement in planning, implementing, and evaluating learning programs from 2017 to 2022 using the Systematic Literature Review (SLR) method. The stages of implementation using the Cooper version are (1) formulating the problem, (2) collecting data, (3) evaluating the feasibility of the data, (4) analysis and interpreting the relevant data, and (5) organizing and presenting the results. Data was collected by searching for keywords related to the concept to be reviewed on the data source page (Google Scholar, Perpusnas.go.id, and Portal Garuda). The results of this study indicate that parental involvement in learning planning is as a giver and recipient of information about the child's condition in the assessment process but has yet to be involved in determining the learning program. Meanwhile, mostly parents accompanied children when studying at home during the pandemic, despite many challenges in the learning implementation. As for the evaluation process, parents monitored their children’s progress and gave feedback to the teachers about their children’s achievements. The findings of this study indicate the need for further studies to improve school-parent collaboration in Indonesia.
Hubungan Kemampuan Literasi Digital dan Kemandirian Siswa dengan Hasil Belajar Matematika di SDN Cimahpar 05 Kota Bogor
Authors: Nur Afianti Avifah Nur Afianti , Rasmitadila Rasmitadila , Muhdiyati Iyon Muhdiyati 
Published: June 2023

Pelaksanaan penelitian ini bertujuan guna mengetahui hubungan antara kemampuan literasi digital dan kemandirian siswa dengan hasil belajar matematika di SDN Cimahpar 05 Kota Bogor pada masa pandemi covid-19. Penelitian ini menggunakan metode kuantitatif dengan jenis penelitian korelasional. Sampel dalam penelitian ini adalah siswa kelas IV, V, dan VI SDN Cimahpar 05 yang berjumlah 69 siswa. Teknik pengumpulan data menggunakan angket. Uji validitas penilaian ahli dan butir instrumen dengan rumus Korelasi Product Moment. Uji reliabilitas menggunakan rumus Alpha Cronbach. Teknik analisis menggunakan analisis statistik deskriptif. Berdasarkan diperoleh nilai signifikansi yaitu sebesar 0,000. Hasil perhitungan data yang diperoleh, diketahui nilai signifikansi kurang dari 0,05 (0,00 kurang dari 0,05) maka dapat disimpulkan bahwasannya kemampuan literasi digital dan kemandirian siswa dengan hasil belajar berkorelasi atau memiliki hubungan dengan interpretasi nilai 0,785 yang termasuk dalam tingkat hubungan yang tinggi.