bluuebunny/crossref_metadata_2025_split huggingface dataset:
Advanced therapy medicinal products in China: Regulation and development
Authors: Lu Jiaqi , Xu Longchang , Wei Wei , He Wu 
Published: April 2023

AbstractAdvanced therapy medicinal products (ATMPs) have shown dramatic efficacy in addressing serious diseases over the past decade. With the acceleration and deepening of China's drug regulatory reforms, the country sees a continuous introduction of policies that encourage drug innovation. The capacity and efficiency of the Center for Drug Evaluation (CDE), National Medical Products Administration have significantly improved, where substantial resources have been allocated to ATMPs with major innovations and outstanding clinical values that satisfy urgent clinical needs. These changes have greatly stimulated the research and development of biological products in China, ushering in a period of explosive growth in the number of investigational new drug (IND) applications of ATMPs. Here, we described China's ATMP regulatory framework and analyzed data on IND applications for ATMPs submitted to CDE. The data show that China's ATMP industry is expanding dramatically, but lagging behind in terms of the innovative targets and the coverage of indications. However, in recent years, the diversity of product types, targets, and indications is growing. We discussed challenges and opportunities in ATMP regulation. Risk‐based regulation and cross‐discipline collaborations are encouraged to promote more ATMPs toward market authorization in China.
Lipid‐Related Genetic Variants for Personalized Dietary Interventions: A Systematic Review
Authors: Rivera‐Íñiguez Ingrid , González‐Becerra Karina , Ramos‐Lopez Omar , Peréz‐Beltrán Yolanda E. , Chagüén‐Hernández Marian S. , Martínez‐López Erika , Mendivil Edgar J. 
Published: April 2023

AbstractDyslipidemias are known risk factors for chronic diseases. Precision nutrition interventions are designed according to characteristics, such as diet, phenotype, and genotype. This systematic review aims to define a panel of genetic variants associated with lipid abnormalities that could be later used in nutrigenetic intervention studies. A systematic review is conducted following the PRISMA‐P. Studies published from January 2010 to December 2020 in English language and humans are included from PubMed and ScienceDirect databases. Articles that demonstrate a strong association between polymorphisms (single nucleotide variation) of genes involved in lipid metabolism and increased risk for dyslipidemia are included. A total of 3031 articles are screened, but only 51 articles fulfill the inclusion criteria. The genes included are FABP2, MTTP related to CM synthesis and secretion; LPL, LIPC involved in triglyceride hydrolysis; CETP, APOA1, LCAT, ABCA1, and APOA5 related to lipoprotein metabolism, and APOE, LDLR, SCARB1, APOC3 involved in lipid clearance. In this systematic review, genetic variants related to chylomicron synthesis, triglyceride hydrolysis, lipoprotein metabolism, and lipid clearance demonstrate a strong association with lipid abnormalities, which can be used to design precision nutrition interventions that may help to prevent and treat dyslipidemia effectively.
A negative group delay rectangular waveguide based on corrugated tantalum nitride slow wave structure
Authors: Liu Zheng , Zhang Jian , Lei Xue , Zhang Li , Wang Kexin , Xu Zhijian 
Published: April 2023

AbstractIn this letter, a rectangular waveguide with controlled negative group delay (NGD) is proposed. The equivalent circuit of the structure is proposed and analyzed. The NGD value and NGD center frequency can be adjusted continuously by the corrugation width and height. Simulation results showed that NGD values of up to −0.7 ns were achievable. The fractional bandwidth was up to 5.67%, at which point the NGD response was observed. A prototype of the proposed structure was fabricated and characterized. Results showed that the fabricated structure was capable of generating a group delay of up to −0.09 ns at 18.9–20 GHz, which was consistent with theoretical and simulated predictions. To the best of our knowledge, this is the first time negative group delay has been achieved in the microwave‐band in a rectangular waveguide.
Motion‐resolved fat‐fraction mapping with whole‐heart free‐running multiecho GRE and pilot tone
Authors: Mackowiak Adèle L. C. , Roy Christopher W. , Yerly Jérôme , Falcão Mariana B. L. , Bacher Mario , Speier Peter , Piccini Davide , Stuber Matthias , Bastiaansen Jessica A. M. 
Published: April 2023

PurposeTo develop a free‐running 3D radial whole‐heart multiecho gradient echo (ME‐GRE) framework for cardiac‐ and respiratory‐motion‐resolved fat fraction (FF) quantification.Methods(NTE = 8) readouts optimized for water–fat separation and quantification were integrated within a continuous non‐electrocardiogram‐triggered free‐breathing 3D radial GRE acquisition. Motion resolution was achieved with pilot tone (PT) navigation, and the extracted cardiac and respiratory signals were compared to those obtained with self‐gating (SG). After extra‐dimensional golden‐angle radial sparse parallel‐based image reconstruction, FF, R2*, and B0 maps, as well as fat and water images were generated with a maximum‐likelihood fitting algorithm. The framework was tested in a fat–water phantom and in 10 healthy volunteers at 1.5 T using NTE = 4 and NTE = 8 echoes. The separated images and maps were compared with a standard free‐breathing electrocardiogram (ECG)‐triggered acquisition.ResultsThe method was validated in vivo, and physiological motion was resolved over all collected echoes. Across volunteers, PT provided respiratory and cardiac signals in agreement (r = 0.91 and r = 0.72) with SG of the first echo, and a higher correlation to the ECG (0.1% of missed triggers for PT vs. 5.9% for SG). The framework enabled pericardial fat imaging and quantification throughout the cardiac cycle, revealing a decrease in FF at end‐systole by 11.4% ± 3.1% across volunteers (p < 0.0001). Motion‐resolved end‐diastolic 3D FF maps showed good correlation with ECG‐triggered measurements (FF bias of −1.06%). A significant difference in free‐running FF measured with NTE = 4 and NTE = 8 was found (p < 0.0001 in sub‐cutaneous fat and p < 0.01 in pericardial fat).ConclusionFree‐running fat fraction mapping was validated at 1.5 T, enabling ME‐GRE‐based fat quantification with NTE = 8 echoes in 6:15 min.
Validation of image interpretation for direct vision‐guided feeding tube placement
Authors: Taylor Stephen J. , Milne Danielle , Zeino Zeino , Griffiths Leonard , Clemente Rowan , Greer‐Rogers Frances , Brown Jules 
Published: April 2023

AbstractBackgroundUnguided (blind) tube placement commonly results in lung (1.6%) and oesophageal (5%) misplacement, which can lead to pneumothorax, aspiration pneumonia, death, feeding delays, and increased cost. Use of real‐time direct vision may reduce risk. We validated the accuracy of a guide to train new operators in the use of direct vision–guided tube placement.MethodsUsing direct vision, operators matched anatomy viewed to anatomical markers in a preliminary operator guide. We examined how accurately the guide predicted tube position, specifically whether respiratory and gastrointestinal placement could be differentiated.ResultsA total of 100 patients each had one tube placement. Placement was aborted in 6% because of inability to enter or move beyond the oesophagus. In 15 of 20 placements in which the glottic opening was identified, the tube was maneuvered to avoid entry into the respiratory tract. Of 96 tubes that reached the oesophagus, 17 had entered the trachea; all were withdrawn pre‐carina. One or more specific characteristics identified each organ, differentiating the trachea‐oesophagus (P < 0.0001), oesophagus‐stomach, and stomach‐intestine in 100%. End‐of‐procedure tube position was ascertained by pH ≤4.0 (gastric) of aspirated fluid and/or x‐ray (gastric or intestinal). In patients with a trauma risk (13%), it was avoided by identification that the tube remained within the nasal, oesophageal, or gastric lumen.ConclusionOperators successfully matched anatomy seen by direct vision to images and descriptions of anatomy in the “operator guide.” This validated that the operator guide accurately facilitates interpretation of tube position and enabled avoidance of lung trauma and oesophageal misplacement.
Birds for Isis: The evidence from Pompeii
Authors: Corbino Chiara Assunta , Demarchi Beatrice 
Published: April 2023

AbstractPeople have always been fascinated by birds. In the Roman period, birds (particularly chicken) were still largely employed in several rituals. Although Roman writers, such as Cicero, Livy, Pliny the Elder, and Aelian, inform us about the use of birds in a number of rituals, the archaeological evidence rarely allows us to associate the collected zooarchaeological remains with a single deity.In 2017, a well‐preserved archaeological context located in the vicinity of the temple of Isis in Pompeii and related to a single ritual event (dated to the mid‐1st century CE), revealed a number of faunal remains as well as ceramic and archaeobotanical finds. Chicken dominates the assemblage, followed by goose, pigeon, and turtle dove. A few remains of pig and a marine bivalve, the truncate donax, were also recovered. Skeletally young chickens were largely employed in the ritual, whereas the other bird taxa are only represented by mature bones. Chicken eggshell, taxonomically identified using ancient protein analysis, was also found. Taphonomic evidence indicates that bird bones were still covered with meat when exposed to the ritual fire. The results obtained have been linked to relevant written and iconographic sources dated to the Roman period. This work confirms that bird sacrifice was an important part of the Isis rituals. Among the birds involved, goose could be considered a possible marker of that goddess. The evidence from Pompeii adds new insights into our knowledge of the animals in the Isis cult during the 1st century CE.
Cosmology from Non‐Minimal Geometry‐Matter Coupling
Authors: Gonçalves B.S. , Moraes P.H.R.S. , Mishra B. 
Published: April 2023

AbstractWe construct a cosmological model from the inception of the Friedmann‐Lemâitre‐Robertson‐Walker metric into the field equations of the gravity theory, with R being the Ricci scalar and being the matter lagrangian density. The formalism is developed for a particular function, namely , with σ being a constant that carries the geometry‐matter coupling. Our solutions are remarkably capable of evading the Big‐Bang singularity as well as predict the cosmic acceleration with no need for the cosmological constant, but simply as a consequence of the geometry‐matter coupling terms in the Friedmann‐like equations.
Functional differentiation of two general‐odorant binding proteins in Hyphantria cunea (Drury) (Lepidoptera: Erebidae)
Authors: Zhang Xiaoqing , Purba Endang R. , Sun Jing , Zhang Qing‐He , Dong Shuang‐Lin , Zhang Ya‐Nan , He Peng , Mang Dingze , Zhang Longwa 
Published: April 2023

AbstractBACKGROUNDGeneral odor‐binding proteins (GOBPs) play critical roles in insect olfactory recognition of sex pheromones and plant volatiles. Therefore, the identification of GOBPs in Hyphantria cunea (Drury) based on their characterization to pheromone components and plant volatiles is remain unknown.RESULTSIn this study, two H. cunea (HcunGOBPs) genes were cloned, and their expression profiles and odorant binding characteristics were systematically analyzed. Firstly, the tissue expression study showed that both HcunGOBP1 and HcunGOBP2 were highly expressed in the antennae of both sexes, indicating their potential involvement in the perception of sex pheromones. Secondly, these two HcunGOBPs genes were expressed in Escherichia coli and ligand binding assays were used to assess the binding affinities to its sex pheromone components including two aldehydes and two epoxides, and some plant volatiles. HcunGOBP2 showed high binding affinities to two aldehyde components (Z9, Z12, Z15‐18Ald and Z9, Z12‐18Ald), and showed low binding affinities to two epoxide components (1, Z3, Z6‐9S, 10R‐epoxy‐21Hy and Z3, Z6‐9S, 10R‐epoxy‐21Hy), whereas HcunGOBP1 showed weak but significant binding to all four sex pheromone components. Furthermore, both HcunGOBPs demonstrated variable binding affinities to the plant volatiles tested. Thirdly, in silico studies of HcunGOBPs utilized homology, structure modeling, and molecular docking revealed critical hydrophobic residues might be involved in the binding of HcunGOBPs to their sex pheromone components and plant volatiles.CONCLUSIONOur study suggests that these two HcunGOBPs may serve as potential targets for future studies of HcunGOBPs ligand binding, providing insight in the mechanism of olfaction in H. cunea. © 2023 Society of Chemical Industry.
The impostor phenomenon in post‐secondary students: A review of the literature
Authors: Ménard A. Dana , Chittle Laura 
Published: April 2023

AbstractThe impostor phenomenon (IP) is characterised by a belief that one is not actually intelligent or accomplished, despite objective evidence of success, but rather has fooled others and is therefore vulnerable to discovery as a fraud. Impostor feelings are widespread in the post‐secondary population and may be disproportionately experienced by groups already marginalised within academia (e.g., women, racialised students). The IP may be associated with significant mental health issues and changes long‐term education and career plans; as such, it is imperative that administrators take steps to address impostorism on university and college campuses. The purpose of this review was to summarise factors of the IP from existing research on the experiences and background characteristics of undergraduate, graduate and professional students (i.e., medicine, law). Findings on the subject of IP and gender as well as IP and ethnicity were inconsistent. Most studies found that IP was negatively related to self‐esteem and various dimensions of mental health. The relationship of IP to grade point average was inconsistent but several studies showed a negative association between IP and measures of academic performance. These findings suggest there is a critical need to bring awareness to and address experiences of the IP in the academic community; implications for campus mental health professionals are explored. Limitations of existing research are addressed and directions for future research are discussed.
Context and implicationsRationale for this studyTo offer a summary of findings related to experiences of the IP among students in higher education.Why the new findings matterIP is negatively associated with multiple mental health concerns, self‐esteem, and measures of academic performance; therefore, interventions are needed to better support students in their academic pursuits.Implications for higher education personnel (e.g., professors, administrators)Implications for mental health professionals and students are discussed. Recommendations for intervention include raising awareness and normalising feelings of IP through workshops and orientations, and resource development with a particular focus on practical strategies to support students in coping with feelings of IP. Earlier intervention to manage IP is needed to curb associated mental health issues and deleterious changes to long‐term education and career plans.
Mayer‐Rokitansky‐Küster‐Hauser syndrome presented as recurrent urinary tract infection in childhood (case report)
Authors: Falsafi Nargess , Amirzargar Hossein , Moghtaderi Mastaneh 
Published: April 2023

AbstractBackgroundMayer‐Rokitansky‐Küster‐Hauser syndrome (MRKH) is characterized by the absence of the uterus and upper two‐thirds of the vagina, normal secondary sexual development, and 46XX karyotype is one of the rare types of Mullerian agenesis. There may be associated congenital anomalies in other organ systems especially those with the same embryogenesis such as the urinary tract mostly in its upper parts present in 40% of cases including renal agenesis, ectopic kidney (unilateral or bilateral), renal hypoplasia, horseshoe kidneys, and hydronephrosis. Other organ systems also may be affected such as skeletal and auditory systems. MRKH is diagnosed mostly during or after adolescence because of unexpected amenorrhea or disturbed sexual experiences.Case reportWe present a 3‐year‐old girl coming with recurrent bouts of urinary tract infections diagnosed as having MRKH syndrome established by imaging and genetic studies. Our case is very rare and interesting because it presents itself as a recurrent urinary tract infection in early childhood which is rare and unusual. In this case, early detection helped us to prevent chronic kidney disease and also planning to perform necessary minimal but very important surgical procedures before initiation of sexual activities to relieve the psychosocial aspect of the syndrome both for the child and parents.ConclusionHealth givers should keep in mind that rare syndromes may present as a repeated quite common problem or have confusing or conceiving presentations. This point will assist us in the early detection of rare diseases at an earlier age or stage.
Robotic date fruit harvesting using machine vision and a 5‐DOF manipulator
Authors: Mohammadi Parvin , Massah Jafar , Asefpour Vakilian Keyvan 
Published: April 2023

AbstractDate fruits can be found at the highest point of the palm tree, so harvesting can be a dangerous task for humans. In this study, a robotic arm is presented to harvest date fruits. A manipulator, traveling on a U‐shaped rail with four prismatic joints and one revolute joint, was designed and constructed to approach the fruits efficiently. The end‐effector of the manipulator was an electric chainsaw capable of cutting the date bunch. Two cameras were located on the manipulator in perpendicular directions to capture images, which were then transmitted to a decision‐making unit to control the speed of the manipulator links. The decision‐making unit included three fuzzy inference systems that used the location data of the fruit bunch stems and the area of tree leaves in the images to determine the speed of electromotors of the trolley, horizontal link, and vertical link. An artificial palm tree with dimensions similar to a real palm tree was constructed to evaluate the performance of the robot. The performance of the robot was evaluated in various lighting conditions. The results showed that the introduced image processing algorithm could adequately detect the stems of the date bunches with accuracy, precision, and recall of 0.88, 0.92, and 0.96, respectively, in suitable lighting, that is, when there was sufficient natural lighting. Moreover, the experimental results revealed that the accuracy of the control system in cutting the stems was 87%, with a production loss of 5%. The proposed robot makes it possible to improve the capacity of using mechanized harvesting in date palm fields.
A multi‐parameter approach to quantify riverbed clogging and vertical hyporheic connectivity
Authors: Negreiros B. , Galdos A. Aybar , Seitz L. , Noack M. , Schwindt S. , Wieprecht S. , Haun S. 
Published: April 2023

AbstractRiverbed clogging is key to assessing vertical connectivity in the hyporheic zone and is often quantified using single‐parameter or qualitative approaches. However, clogging is driven by multiple, interacting physical and bio‐geochemical parameters, which do not allow for a conclusive assessment of hyporheic connectivity with single‐parameter approaches. In addition, existing qualitative assessments lack transparency and repeatability. This study introduces a Multi‐Parameter Approach to quantify Clogging and vertical hyporheic connectivity (MultiPAC), which builds on standardized measurements of physical (grain size characteristics, porosity, hydraulic conductivity) and bio‐geochemical (interstitial dissolved oxygen) parameters. We apply MultiPAC at three gravel‐bed rivers and show how the set of parameters provides a representative appreciation of physical riverbed clogging, thus quantifying vertical hyporheic connectivity. However, more parameters are required to fully characterize biological clogging. In addition, MultiPAC locates clogged layers in the hyporheic zone through multi‐parameter vertical profiles over the riverbed depth. The discussion outlines the relevance of MultiPAC to guide field surveys.
Synthesis of Cationic Starch Compound Emulsion by Graft Copolymerization with Tea Polyphenols and AEM5700
Authors: Li Shaoxiang , Wang Lijie , Liu Jiaxin , Li Houwei , Qu Wenjuan , Cheng Jiaji , Wang Dong 
Published: April 2023

AbstractAn antibacterial biobased compound emulsion is prepared by modifying cationic oxidized starch grafted styrene‐acrylic emulsion with 3‐(trimethoxysilyl)‐propyldimethyloctadecyl ammonium chloride (AEM5700) and tea polyphenols. The biobased compound emulsion exhibits better stability, chemical properties, and antibacterial properties. The structure and surface morphology of biobased compound emulsion are characterized by Fourier Transform infrared spectroscopy (FTIR) and transmission electron microscopy (TEM). The thermal stability of biobased compound emulsion is improved, which can be concluded from the thermogravimetric analysis (TGA). The surface morphology of film is observed by the atomic force microscope (AFM). The wetting property of emulsion film is tested by contact angle test. When the compound ratio is 1.5, the biobased antibacterial compound emulsion has better stability and antibacterial properties. Compared to a single antibacterial agent, the inhibition zone increases by 4–5.5 mm. In addition, the polymerization mechanism of the biobased antibacterial emulsion is analyzed.
Residual tissue magnesium concentration in jellyfish (Aurelia aurita and Cassiopea andromeda) following magnesium chloride euthanasia
Authors: Millar Zachary , Kecheliev Dimo , Wolvin Sophie , LePage Véronique , Lumsden John S. 
Published: April 2023

AbstractMagnesium chloride in high concentration is used for euthanasia of jellyfish to limit overpopulation and for predatory species consumption, but its use could lead to magnesium bioaccumulation and subsequent negative effects in consumers. Two species of scyphozoan jellyfish (Cassiopea andromeda and Aurelia aurita) were subjected to freezing (control), or magnesium chloride baths (144 g/L), with subsequent 30 min baths (one or two) in fresh artificial saltwater and submitted for inductively coupled plasma analysis to determine tissue concentration. Frozen jellyfish consistently yielded the lowest magnesium concentrations, while magnesium chloride euthanized individuals contained the highest concentrations in both species. C. andromeda displayed a significantly higher (p < .05) magnesium absorption capacity than A. aurita in both trials. Single and double baths significantly decreased magnesium concentrations (p < .05) in both species, however, magnesium remained consistently elevated compared to frozen specimens. This study demonstrated species‐specific magnesium accumulation in jellyfish posteuthanasia and that rinsing was an effective method to limit excessive magnesium that could be deleterious to animals in public display aquaria. Magnesium concentrations of tissue and receiving water should be tested if magnesium chloride euthanasia is utilized for dietary supplementation in small bodies of water.
Separation of Single Core and Multicore Lytic Granules by Subcellular Fractionation and Immunoisolation
Authors: Schirra Claudia , Alawar Nadia , Becherer Ute , Chang Hsin-Fang 
Published: April 2023

AbstractSubcellular fractionation is an important tool used to separate intracellular organelles, structures or proteins. Here, we describe a stepwise protocol to isolate two types of lytic granules, multicore (MCG), and single core (SCG), from primary murine CTLs. We used cell disruption by nitrogen cavitation followed by separation of organelles via discontinuous sucrose density gradient centrifugation. Immunoisolation with a Synaptobrevin 2 antibody attached to magnetic beads was then used to harvest Synaptobrevin 2 positive granules for immunoblotting, mass spectrometry, electron, and light microscopy.