bluuebunny/crossref_metadata_2025_split huggingface dataset:
Biodegradation, Water Sorption Isotherms and Thermodynamic Properties of Extruded Packaging Composed of Cassava Starch With Tomato Peel
Authors: Cotta Anômora Ariane Rochido dos Santos , Ferreira Laura Fonseca , Borges Soraia Vilela , Nascimento Bruna de Souza , Cotta Alexandre Alberto Chaves , Dias Marali Vilela 
Published: July 2023

Abstract
Scientists are developing new technologies for biodegradable active packaging made from natural polymers and antioxidant agents as a more sustainable alternative to conventional packaging made from fossil fuels. In this study, the biodegradation of the films was evaluated using techniques such as Fourier transform infrared spectroscopy (FTIR), thermogravimetry (TG), visual and morphological analysis using scanning electron microscopy (SEM). Water sorption isotherms and thermodynamic parameters were analyzed at different temperatures (5 °C, 15 °C, and 25 °C) and relative humidities until the samples reached a constant weight. The results showed changes in the morphology, color, and mass of the cassava starch films with tomato peel due to biodegradation. FTIR revealed structural changes in the films, while TG/DTG curves did not show significant differences over time. The addition of tomato peel to the polymer matrix resulted in lower water solubility. The Guggenheim-Anderson-de Boer (GAB) model provided the best fit for the water sorption isotherms. The monolayer moisture content (Xm) increased with temperature, indicating the availability of active sites for water sorption in the material. Thermodynamic analyses indicated that lower moisture content corresponded to more active sorption sites, and the sorbed water molecules exhibited greater order. In conclusion, biodegradable active packaging offers an environmentally friendly alternative as it decomposes more rapidly than conventional packaging made from fossil-derived materials. The sorption isotherms demonstrated that the adsorption in the packaging materials is controlled by entropy, emphasizing the importance of the number of available active sites for binding rather than the chemical composition of the film.
Synthesis and Characterization of Bio-nanocomposites Based on Poly(Glycerol Itaconic acid) (PGIt) and Using Poly(ɛ- caprolactone) diol (PCL-diol) as Macro Crosslinkers containing Cloisite Na + to application in Tissue engineering
Authors: Mahdavi Reza , Zahedi Payam , Goodarzi Vahabodin 
Published: July 2023

Abstract
Biomaterials are a crucial issue in the field of tissue engineering. Two types of polymeric biomaterials, such as Poly(glycerol Itaconic acid) (PGIt) and Poly(ɛ-caprolactone) diol (PCL-diol), were synthesized by polycondensation and ring opening polymerization (ROP) respectively. The PCL-diol was selected as a minor phase with 30 and 50 wt.%, and Closite-Na+ was selected as the nanophase with a constant amount of 5 wt.%. Molecular structures PGIt and PCL-diol were analyzed by FTIR, 1H-NMR, and GPC techniques. Microstructures showing the presence of PCL-diol in the PGIt have not created compatible morphologies, albeit the presence of clay nanoparticles has helped to achieve the proper morphologies. Low angle XRD showed exfoliated, and intercalated morphologies can be predicted to pure PGIt and PGIt70PCLdiol30Clay5 samples. Mechanical analysis showed that Young’s modulus and elongation at the break of PGIt50PCLdiol50Clay5 and PGIt100 samples were higher than other samples. DMTA analysis showed that adding PCL-diol into the PGIt increased glass transition temperature (Tg) and storage modulus at 37oC. The master curve of the studied samples was prepared by the WLF equation at body temperature. Hydrocatalytical degradation, contact angles, and MTT analysis showed that all samples behave well in biological conditions. Cell adhesion, Dapi, and Alizarin red analysis were carried out on the selected samples, and their results showed that the presence of PCL-diol and Clay into the PGIt has improved the biological behavior of the sample and PGIt50PCLdiol50Clay5 shows just behavior.
Multi-omics investigation of the resistance mechanisms of Pomalidomide in Multiple Myeloma
Authors: Zhuang Yan , Li Chenyu , Jiang Hua , Li Lu , Zhang Yuanteng , Yu Wei , Fu Weijun 
Published: July 2023

Abstract
Background
Despite significant therapeutic advances over the last decade, Multiple myeloma remains an incurable disease. Pomalidomide is a second-generation Immunomodulatory drug that is commonly used to treat patients with relapsed/refractory multiple myeloma. However, approximately half of the patients exhibit resistance to pomalidomide treatment. While previous studies have identified Cereblon as a primary target of Immunomodulatory drugs’ anti-myeloma activity, it is crucial to explore additional mechanisms that are currently less understood.
Methods
To comprehensively investigate the mechanisms of drug resistance, we conducted integrated proteomic and metabonomic analyses of 12 plasma samples from multiple myeloma patients who had varying responses to pomalidomide. Differentially expressed proteins and metabolites were screened, and were further analyzed using pathway analysis and functional correlation analysis. Also, we estimated the cellular proportions based on ssGSEA algorithm. To investigate the potential role of glycine in modulating the response of MM cells to pomalidomide, cell viability and apoptosis were analyzed.
Results
Our findings revealed a consistent decrease in the levels of complement components in the pomalidomide-resistant group. Additionally, there were significant differences in the proportion of T follicular helper cell and B cells in the resistant group. Furthermore, glycine levels were significantly decreased in pomalidomide-resistant patients, and exogenous glycine administration increased the sensitivity of MM cell lines to pomalidomide.
Conclusions
These results demonstrate distinct molecular changes in the plasma of resistant patients that could be used as potential biomarkers for identifying resistance mechanisms for pomalidomide in multiple myeloma and developing immune-related therapeutic strategies.
The effects of berteroin on inflammatory mediators and antioxidant enzymes expression in human periodontal ligament cells
Authors: Hosokawa Yoshitaka , Hosokawa Ikuko , Shimoyama Masahiro , Okamoto Risa , Ozaki Kazumi , Hosaka Keiichi 
Published: July 2023

Abstract
Berteroin is a bioactive substance classified as an isothiocyanate found in cruciferous vegetables such as cabbage, arugula, and salad leaves. In this study, we aimed to determine whether berteroin exerts anti-inflammatory effects on human periodontal ligament cells (HPDLCs), a resident cells of periodontal tissue. Berteroin suppressed interleukin (IL)-1β or tumor necrosis factor (TNF)-α-induced chemokines (C-C motif chemokine ligand (CCL)2, CCL20, C-X-C motif chemokine ligand (CXCL)10, IL-8, and IL-6) production and intercellular adhesion molecule (ICAM)-1 expression in HPDLCs. In addition, berteroin inhibited phosphorylation of IκB kinase (IKK)-α/β, nuclear factor (NF)-κB p65, and IκB-α and degradation of IκB-α in the NF-κB pathway induced by IL-1β or TNF-α stimulation. Moreover, berteroin could inhibit signal transducer and activator of transcription (STAT)3 phosphorylation in TNF-α-stimulated HPDLC. Furthermore, berteroin increased the expression of the antioxidant enzymes, heme oxygenase (HO)-1 and NAD(P)H quinone dehydrogenase (NQO)1, in IL-1β or TNF-α-stimulated HPDLCs. These results suggest that berteroin may decrease the production of inflammatory mediators in HPDLCs by suppressing the NF-κB pathway, and may also decrease the local reactive oxygen species (ROS) production in periodontal lesions by increasing the production of antioxidant enzymes.
Toxicity prediction and analysis of flavonoid apigenin as a histone deacetylase inhibitor: An in silico approach
Authors: N Divya Rajaselvi , Jida  , Nair Devu B , B Varsha , R Nisha A. 
Published: July 2023

Abstract
Occurrence of cancer is driving up on a global scale that exerts greater implications on the physical, psychological and economic stability of the human population. In the present context, numerous research studies are being conducted to explore and discover the drug molecule as an anticancer agent. Diverse scales of flavonoids entail the human diet, and they displayed prospective curative effects against an array of ailments. Among various categories of flavonoids, apigenin a trihydroxy flavone has been proven to have various pharmacological effects. Molecular docking is a key tool in structural molecular biology and computer assisted drug design. In this study, HDAC inhibitory action of apigenin and its probable toxicity was assessed by docking study using Auto dock platform. Toxicity predictions were evaluated by using tools such as CarcinoPred for carcinogenicity study, pkCSM for ADMET analysis, ProTox-II for rodent oral toxicity, lazar for estimating mutagenicity, BOILED Egg plot analysis for examining the gastrointestinal absorption and blood brain permeability, PASS prediction to identify the various biological functions and DruLiTo program to compute the drug likeness property.
Effect of Jute Nanofibre on the Properties of Waste Polypropylene/Polystyrene /Natural Rubber (wPP/PS/NR) Ter- Polymer Blend
Authors: Adamu Yusuf , Bello Tajjudeen Kolawole , Shehu Umar , Bello Abdullahi , Tanimu Gazali , Isa Muhammed Tijani 
Published: July 2023

Abstract
In this work, the effect of jute nanofibre on ter-blend of waste polypropylene (wPP), polystyrene (PS), and natural rubber (NR) nanocomposite was studied. The nanofibre was produced from jute fibre via a ball milling process after freezing with liquid nitrogen. The produced nanofibre was analyzed using Fourier Transform Infrared Spectroscopy (FTIR) and Dynamic Light Scattering (DLS). The ter-blend was modified with the nanofibre at different weight percentages (2–10 wt%) at 2wt% intervals. The modified polymer blends were characterized for mechanical, thermal, physical and morphological properties. FTIR revealed the removal of hemicellulose, lignin and other impurities from the jute fibre, due to the change in wave numbers observed. The DLS analysis showed that an average of 85.54 nm size distribution by the intensity and Polydispersity Index (PDI) of 0.353 was achieved. Also, the thermogravimetry analysis (TGA) showed that jute nanofibres proved to be thermally stable up to 282 oC. Polymer blends modified with 2 wt% nanofibres had the highest average impact and tensile strengths. While, the percentage water absorption (%WA), showed that sp10% absorbed the highest amount of water after 24 hrs. The weight losses of the modified blend at various temperatures were found to increase with the addition of nanofibre. The Scanning electron microscope (SEM) revealed cracks, voids and blend-separation as the amount of jute nanofibre was increased. While, Dynamic Mechanical Analysis (DMA) revealed that the Tg of the modified blend was improved, while the loss-factor improved greatly by 43%, but the storage and loss-moduli remained unchanged.
Comparing efficacy and safety of Maintenance Therapy for Platinum-Sensitive Recurrent Ovarian Cancer: A Bayesian network meta-regression analyses
Authors: Hao Li , Xing Xuejiao , Liu Chengjiang , Chen Xi , Yang Bin , Wei Tianshu 
Published: July 2023

Abstract
Background Despite surgical and medical efforts in the upfront treatment, about 70% of OC patients have a disease relapse within 2–3 years after diagnosis. ROC is still an incurable condition; targeted agents as maintenance therapies have been shown to improve survival, but the most appropriate maintenance regimens are still controversial and opaque.Objective This Bayesian network meta-regression analysis provides a head-to-head comparison of maintenance therapy PARP-Inhibitors and Angiogenesis Inhibitors for Platinum-Sensitive Recurrent Ovarian Cancer(PSROC) using the BRCA genes status as a covariate.Methods To identify relevant studies, the databases of Pubmed, Scopus, Embase, Web of Science, and the Cochrane Central Register of Controlled Trials were searched until January 31, 2023. Comparing progression-free survival (PFS) and overall survival (OS) of different interventions at the same time node by NMA. NMR was performed on the hazard ratios (HR) associated with PFS and OS as the primary endpoints, with the BRCA genes status as the covariate. The ability of each treatment was ranked using the surface under the cumulative ranking (SUCRA) curve.Results Eventually,16 studies with 5696 patients and 8 maintenance therapy were enrolled.From a horizontal perspective,bevacizumab(HR = 1.83, 95%CI: 1.47 to 2.33), niraparib(HR = 2.9, 95%CI: 2.15 to 3.95), olaparib (HR = 2.74, 95%CI: 2.05 to 3.6) ,rucaparib (HR = 2.61, 95%CI: 1.81 to 3.57) and fuzuloparib (HR = 3.99, 95%CI: 2.41 to 6.6) were significantly superior to the placebo on PFS of AC.Niraparib(HR = 4.08, 95%CI: 1.49 to 11.33), olaparib (HR = 4.29, 95%CI: 1.9 to 9.75) ,rucaparib (HR = 4.16, 95%CI: 1.04 to 16.49) and fuzuloparib(HR = 7.16, 95%CI: 1.63 to 30.82) were significantly superior to the placebo on PFS of BRCAm.Niraparib(HR = 2.33, 95%CI: 1.17 to 4.7) was significantly superior to the placebo on PFS of BRCAwt.From a longitudinal perspective, the results for PFS are similar to the above; Olaparib significantly increased OS rates from the 3rd to the 36th month(HR from4.43 to26.55). Meta-regression analyses support the above conclusions.Conclusions Considering the efficacy, durability, safety, and compliance, one of the standard maintenance therapy, Olaparib, should be recommended as the best choice for PSROC. For BRCAm and BRCAwt patients,Olaparib and niraparib may be the first choice for improving PFS.Furthermore, more head-to-head trials are needed to confirm those findings.
Moderate Levels of Human Disturbance Impact Persecuted Mammals in the Peruvian Amazon Rainforest
Authors: Zwicker Samantha , Gardner Beth 
Published: July 2023

Abstract
Human population growth and associated land conversion in tropical regions have led to habitat fragmentation, resource extraction, and increased hunting pressure, resulting in defaunation. To assess the impacts of human disturbances on 17 mammal species spanning both predator and prey guilds, we conducted an eight-year (2015–2022) camera trap study in the unprotected region of Madre de Dios, Peru. Analyzing 14,849 mammal captures across 293 sites with occupancy models, we assessed the influence of eight ecological and anthropogenic covariates on species occupancy and detection. We hypothesized that the most persecuted species would be most negatively affected by human disturbance. Our results supported this hypothesis; persecuted species including jaguars (Panthera onca), tapirs (Tapirus terrestris), brocket deer (Mazama spp.), collared peccaries (Pecari tajacu), and agoutis (Dasyprocta variegata) exhibited significant changes in occupancy probability in relation to distance from settlements, proximity to agriculture, and land use type. Contrary to our prediction, ocelot and white-lipped peccary occupancy probability did not change with human disturbance covariates; however, there were no detections of white-lipped peccaries in the first seven years of the study. We found that distance to the river was the most common ecological covariate where species occupancy was higher closer to the river. Given the importance of rivers as access points for humans, this emphasizes the significance of protecting riverine habitats in lowland Peruvian Amazonia. Our findings highlight the importance of considering species-specific responses and the need for targeted conservation measures to mitigate the negative effects of human activities on vulnerable and highly persecuted species.
Deep Learning to Detect and Classify Teeth, Dental Caries and Restorations: A Systematic Mapping
Authors: Carneiro José A. , Zancan Breno G. , Tirapelli Camila , Macedo Alessandra A. 
Published: July 2023

Abstract
Purpose: Oral health is an indicator of individuals' health and quality of life. Consequently, it is a concerning topic faced everyday by healthcare professionals. X-ray images are essential resources for detecting oral problems. Artificial Intelligence has gained attention in the detection of oral diseases and conditions. We carry out a systematic mapping in the literature regarding the application of deep learning in dental radiographs for detection, segmentation, and classification of teeth, caries, and restorations.
Methods: Through automated searches in the ACM Digital Library, IEEE Xplore Digital Library, PubMed, and Scopus, 394 primary articles were found, published between 2012-2023. After applying inclusion and exclusion criteria, 69 articles were read and analyzed considering: consistency and adequacy of the used databases, implemented techniques, and results.
Results: 40.82% of the analyzed articles did not present clear information on the approval of ethics committees to carry out the research. Although the application of computational techniques in oral health is an interdisciplinary topic, 37.68% of the 69 surveys were conducted by teams composed only of professionals from one area. 66.67% of the articles explored only panoramic radiographs and the most used metrics were accuracy, recall, and precision. The U-Net and Mask R-CNN networks were the most applied.
Conclusion: Despite the increase in the number of investigations, some challenges, such as the low availability of public data sets, the lack of details in the developed methodologies, and the lack of standardization when presenting results, complicate a fair comparison between papers, which is an obstacle to be overcome.
The influence of scald and anoxia to the expression of Glycine receptor in rats’ myocardium and the co-localization study of Glycine receptor and endoplasmic reticulum
Authors: Wu Yue , Lu RuoNan , Zhang Li , Bai Mingming , Cai Hui , Zhou Junli 
Published: July 2023

Abstract
PURPOSE The objectives of the current study were to demonstrate the influence of scald and anoxia to the expression of glycine receptor in rats’ myocardium and the co-localization of glycine receptor and endoplasmic reticulum.
METHOD (1) Effect of hypoxia on Gly Rα1 expression : Rat cardiomyocytes line H9C2 were cultured and divided into 3 groups randomly: the Glycine group, the Hypoxia group and the Glycine+Hypoxia group and incubated for 0 h, 3 h, 6 h, 12 h, 24 h or 48 h. A total of 24 SD rats were divided into 4 groups: the Control group, the Glycine group, the Scald group and the Glycine+Scald group.The Western blot method detected the expression of Gly Rα1 in each group. (2) Effect of hypoxia on colocalization of GlyR and ER: We labeled ER with Rodamine (red), GlyRα1 (green) with FITC, DNA (blue) with DAPI, and finally, photographed cells with laser confocal microscopy . H9C2 were cultured and divided into 3 groups randomly (the Glycine group, the Hypoxia group and the Gly+Hyp group) and ncubated for 0 h, 3 h, 6 h, 12 h, 24 h or 48 h. Mean density of Gly Rα1 in Each group of time phase was detected.
RESULT glycine obviously decreased the mortality rate of H9C2 cells under anoxic condition. Moreover, the expression level of GlyRα1was found to be increased in a time dependent manner under anoxic condition, and glycine could conspicuously reverse the increased expression of GlyRα1. Furthermore, we confirmed that GlyRα1 localized on ER in cardiomyocyte and the combination of glycine with GlyRα1 on ER caused cytoprotective effect by potential membrane changes. In vivostudies, the protective effects of glycine was also investigated on burned rat models.
CONCLUSION the present study confirmed glycine could protect myocardial cells from being injured through reducing the expression of GlyRα1 under anoxic condition both in vivo and in vitro assays, and combination of glycine with GlyRα1 happened on ER of myocardial cells.
The synthesis of spherical polymeric ionic liquid catalyst and its catalysis for CO2 to dimethyl carbonate by one-pot methods
Authors: Liu Wenqiang , Wang Yajuan , Li Jiangxin , Zhang Juan 
Published: July 2023

Abstract
Dimethyl carbonate (DMC) is widely used and nontoxic and can replace more dangerous materials such as dimethyl sulfate or methyl chloride. Spherical particle catalysts (PILs-XSS) were synthesized by suspension polymerization, which was characterized by SEM-EDS, FT-IR, TG, and BET-BJH. The characterization results showed that PILs-XSS had a specific core structure, a certain pore size (14.3nm), and surface area size (71.5m2/g), and remained stable at 293.4°C. The catalyst performance was evaluated by a one-pot synthesis of dimethyl carbonate. The process conditions were optimized in detail. The optimal reaction conditions were as follows: the dosage of PILs-XSS was 2.5 wt %, the CO2 pressure was 1.5 MPa, the reaction temperature was 100°C, the reaction time was 4 h, the molar ratio of methanol to propylene oxide (PO)was 3: 1, and the dosage of cocatalyst Na2CO3 was 3 wt %. Under the optimum conditions, the conversion of PO was up to 98.8% and the yield of DMC reached 53.7%. In addition, the combined catalyst PILs-Na2CO3 was easily recovered by filtration in the reaction system. After five times of repeated use, the activity and the shape of the catalyst were almost unchanged, which meant that the catalyst had amazing mechanical strength. This study found that the transesterification catalyst Na2CO3 not only had good transesterification efficiency but also promoted the reaction of CO2.