bluuebunny/crossref_metadata_2025_split huggingface dataset:
The rebrightening of aROSAT-selected tidal disruption event: repeated weak partial disruption flares from a quiescent galaxy?
Authors: Malyali A , Liu Z , Rau A , Grotova I , Merloni A , Goodwin A J , Anderson G E , Miller-Jones J C A , Kawka A , Arcodia R , Buchner J , Nandra K , Homan D , Krumpe M 
Published: January 2023

ABSTRACTThe ROSAT-selected tidal disruption event (TDE) candidate RX J133157.6−324319.7 (J1331) was detected in 1993 as a bright [0.2–2 keV flux of (1.0 ± 0.1) × 10−12 erg s−1 cm−2], ultra-soft (kT = 0.11 ± 0.03 keV) X-ray flare from a quiescent galaxy (z = 0.051 89). During its fifth all-sky survey (eRASS5) in 2022, Spectrum-Roentgen-Gamma (SRG)/ eROSITA detected the repeated flaring of J1331, where it had rebrightened to an observed 0.2–2 keV flux of (6.0 ± 0.7) × 10−13 erg s−1 cm−2, with spectral properties (kT = 0.115 ± 0.007 keV) consistent with the ROSAT-observed flare ∼30 yr earlier. In this work, we report on X-ray, ultraviolet, optical, and radio observations of this system. During a pointed XMM observation ∼17 d after the eRASS5 detection, J1331 was not detected in the 0.2–2 keV band, constraining the 0.2–2 keV flux to have decayed by a factor of ≳40 over this period. Given the extremely low probability (∼5 × 10−6) of observing two independent full TDEs from the same galaxy over a 30 yr period, we consider the variability seen in J1331 to be likely caused by two partial TDEs involving a star on an elliptical orbit around a black hole. J1331-like flares show faster rise and decay time-scales [$\mathcal {O}(\mathrm{d})$] compared to standard TDE candidates, with negligible ongoing accretion at late times post-disruption between outbursts.
The Pristine survey – XX. GTC follow-up observations of extremely metal-poor stars identified from Pristine and LAMOST
Authors: Arentsen Anke , Aguado David S , Sestito Federico , González Hernández Jonay I , Martin Nicolas F , Starkenburg Else , Jablonka Pascale , Yuan Zhen 
Published: January 2023

ABSTRACT
Ultra-metal-poor stars ($\rm {[Fe/H]} \lt -4.0$) are very rare, and finding them is a challenging task. Both narrow-band photometry and low-resolution spectroscopy have been useful tools for identifying candidates, and in this work, we combine both approaches. We cross-matched metallicity-sensitive photometry from the Pristine survey with the low-resolution spectroscopic Large Sky Area Multi-Object Fibre Spectroscopic Telescope (LAMOST) data base, and re-analysed all LAMOST spectra with $\rm {[Fe/H]} _{\rm Pristine} \lt -2.5$. We find that ∼1/3rd of this sample (selected without $\rm {[Fe/H]} _{\rm Pristine}$ quality cuts) also have spectroscopic $\rm {[Fe/H]} \lt -2.5$. From this sample, containing many low signal-to-noise ratio (S/N) spectra, we selected 11 stars potentially having $\rm {[Fe/H]} \lt -4.0$ or $\rm {[Fe/H]} \lt -3.0$ with very high carbon abundances, and we performed higher S/N medium-resolution spectroscopic follow-up with the Optical System for Imaging and low Resolution Integrated Spectroscopy (OSIRIS) on the 10.4-m Gran Telescopio Canarias (GTC). We confirm their extremely low metallicities, with a mean of $\rm {[Fe/H]} = -3.4$, and the most metal-poor star having $\rm {[Fe/H]} = -3.8$. Three of these are clearly carbon-enhanced metal-poor (CEMP) stars with $+1.65 \lt \rm {[C/Fe]} \lt +2.45$. The two most carbon-rich stars are either among the most metal-poor CEMP-s stars or the most carbon-rich CEMP-no stars known, the third is likely a CEMP-no star. We derived orbital properties for the OSIRIS sample and find that only one of our targets can be confidently associated with known substructures/accretion events, and that three out of four inner halo stars have prograde orbits. Large spectroscopic surveys may contain many hidden extremely and ultra-metal-poor stars, and adding additional information from e.g. photometry as in this work can uncover them more efficiently and confidently.
There and back again: Understanding the critical properties of backsplash galaxies
Authors: Borrow Josh , Vogelsberger Mark , O’Neil Stephanie , McDonald Michael A , Smith Aaron 
Published: January 2023

ABSTRACT
Backsplash galaxies are galaxies that once resided inside a cluster, and have migrated back outside as they move towards the apocentre of their orbit. The kinematic properties of these galaxies are well understood, thanks to the significant study of backsplashers in dark matter-only simulations, but their intrinsic properties are not well-constrained due to modelling uncertainties in subgrid physics, ram pressure stripping, dynamical friction, and tidal forces. In this paper, we use the IllustrisTNG300-1 simulation, with a baryonic resolution of Mb ≈ 1.1 × 107 M⊙, to study backsplash galaxies around 1302 isolated galaxy clusters with mass 1013.0 &lt; M200,mean/M⊙ &lt; 1015.5. We employ a decision tree classifier to extract features of galaxies that make them likely to be backsplash galaxies, compared to nearby field galaxies, and find that backsplash galaxies have low gas fractions, high mass-to-light ratios, large stellar sizes, and low black hole occupation fractions. We investigate in detail the origins of these large sizes, and hypothesize their origins are linked to the tidal environments in the cluster. We show that the black hole recentring scheme employed in many cosmological simulations leads to the loss of black holes from galaxies accreted into clusters, and suggest improvements to these models. Generally, we find that backsplash galaxies are a useful population to test and understand numerical galaxy formation models due to their challenging environments and evolutionary pathways that interact with poorly constrained physics.
A photometric study of NSVS 7453183: a probable quadruple system with long-term surface activity
Authors: Šmelcer L , Wolf M , Kučáková H , Zasche P , Kára J , Hornoch K , Zejda M , Auer R F 
Published: January 2023

ABSTRACTThe VRC light curves were regularly measured for the eclipsing binary NSVS 7453183 as a part of our long-term observational project for studying of low-mass eclipsing binaries with a short orbital period and surface activity. The TESS light curve solution in phoebe results to the detached configuration, where the temperature of primary component was adopted to T1 = 4300 K according to the SED approximation. It gives us T2 = 4080 ± 100 K for the secondary component. The spectral type of the primary component was estimated to be K6, and the photometric mass ratio was derived q = 0.86. We confirm presence of the third body in this system, a stellar companion with a minimal mass 0.33 M⊙ orbiting the eclipsing pair with a short period about 425 days, and propose the next, fourth body with a longer orbiting period of about 12 years, probably a brown dwarf with the minimal mass of 50 MJup. The hierarchical structure ((1+1)+1) + 1 of this quadruple system is assumed. Characteristics and temporal variations of the dark region on the surface of the primary component were estimated. The average migration speed of about 10° per month was found during years 2020–2022.
Draft Genome Sequence Data for Erwinia amylovora Strain S618-2-2 Isolated from Pyrus sinkiangensis in China
Authors: Fei Nuoya , Song Bo , Yang Yuwen , Zhu Xiaofeng , Guan Wei , Zhao Tingchang 
Published: January 2023

Fire blight in China was first discovered in Yili Kazak Autonomous Prefecture and Bayingolin Mongolian Autonomous Prefecture, Xinjiang Uygur Autonomous Region, in 2016. Here, we report the draft genome sequence of Erwinia amylovora strain S618-2-2, which was isolated from Pyrus sinkiangensis in China, Xinjiang Uygur Autonomous Region. This is the first genome announcement of an Erwinia amylovora strain in China. [Formula: see text] Copyright © 2023 The Author(s). This is an open access article distributed under the CC BY-NC-ND 4.0 International license .
ANGPTL4 inhibits granulosa cell proliferation in polycystic ovary syndrome by EGFR/JAK1/STAT3‐mediated induction of p21
Authors: Jiang Qi , Miao Ruolan , Wang Yuhuan , Wang Wenqi , Zhao Dingying , Niu Yue , Ding Qiaoqiao , Li Yan , Leung Peter C. K. , Wei Daimin , Chen Zi‐Jiang 
Published: January 2023

AbstractPolycystic ovary syndrome (PCOS) is one of the most common, heterogenous endocrine disorders and is the leading cause of ovulatory obstacle associated with abnormal folliculogenesis. Dysfunction of ovarian granulosa cells (GCs) is recognized as a major factor that underlies abnormal follicle maturation. Angiopoietin‐like 4 (ANGPTL4) expression in GCs differs between patients with and without PCOS. However, the role and mechanism of ANGPTL4 in impaired follicular development are still poorly understood. Here, the case–control study was designed to investigate the predictive value of ANGPTL4 in PCOS while cell experiments in vitro were set for mechanism research. Results found that ANGPTL4 levels in serum and in follicular fluid, and its expression in GCs, were upregulated in patients with PCOS. In KGN and SVOG cells, upregulation of ANGPTL4 inhibited the proliferation of GCs by blocking G1/S cell cycle progression, as well as the molecular activation of the EGFR/JAK1/STAT3 cascade. Moreover, the STAT3‐dependent CDKN1A(p21) promoter increased CDKN1A transcription, resulting in remarkable suppression effect on GCs. Together, our results demonstrated that overexpression of ANGPTL4 inhibited the proliferation of GCs through EGFR/JAK1/STAT3‐mediated induction of p21, thus providing a novel epigenetic mechanism for the pathogenesis of PCOS.
Conductive Hearing Loss Estimated From Wideband Acoustic Immittance Measurements in Ears With Otitis Media With Effusion
Authors: Merchant Gabrielle R. , Neely Stephen T. 
Published: January 2023

Objectives:
Previous work has shown that wideband acoustic immittance (WAI) is sensitive to the volume of effusion present in ears with otitis media with effusion (OME). Prior work also demonstrates that the volume of the effusion appears to drive, or at least play a significant role in, how much conductive hearing loss (CHL) a child has due to a given episode of OME. Given this association, the goal of this work was to determine how well CHL could be estimated directly from WAI in ears with OME.

Design:
Sixty-three ears from a previously published study on OME (ages 9 months to 11 years, 2 months) were grouped based on effusion volume (full, partial, or clear) determined during tympanostomy tube placement surgery and compared with age-matched normal control ears. Audiometric thresholds were obtained for a subset of the 34 ears distributed across the four groups. An electrical-analog model of ear-canal acoustics and middle-ear mechanics was fit to the measured WAI from individual ears. Initial estimates of CHL were derived from either (1) average absorbance or (2) the model component thought to represent damping in the ossicular chain.

Results:
The analog model produced good fits for all effusion-volume groups. The two initial CHL estimates were both well correlated (87% and 81%) with the pure-tone average hearing thresholds used to define the CHL. However, in roughly a third of the ears (11/34), the estimate based on damping was too large by nearly a factor of two. This observation motivated improved CHL estimates.

Conclusions:
Our CHL estimation method can estimate behavioral audiometric thresholds (CHL) within a margin of error that is small enough to be clinically meaningful. The importance of this finding is increased by the challenges associated with behavioral audiometric testing in pediatric populations, where OME is the most common. In addition, the discovery of two clusters in the damping-related CHL estimate suggests the possible existence of two distinctly different types of ears: pressure detectors and power detectors.
Correction of Pediatric Cubitus Varus by Centralization of the Distal Humeral Fragment: A Surgical Technique to Avoid Lateral Condylar Prominence
Authors: Liu Yong , Kan Lisheng , Sun Jun , Chu Xiangjun 
Published: January 2023

Background:
Cubitus varus is a well-recognized late complication of supracondylar humerus fractures in children. Various osteotomies have been described to correct this deformity, but each has disadvantages. The purpose of this study was to investigate the outcomes of a surgical technique, lateral closing wedge osteotomy combined with centralization of the distal humeral fragment, in cubitus varus. Meanwhile, the occurrence of postoperative lateral condylar prominence was observed.

Methods:
From January 2015 to December 2019, 36 pediatric cubitus varus deformity patients who were treated with lateral closing wedge osteotomy combined with centralization of the distal fragment in our institution were included. The corrective osteotomies were performed through a standard lateral approach and fixed with crossed Kirschner wires. The preoperative and postoperative full-length anteroposterior and lateral radiographs of bilateral upper limbs were assessed. At the same time, clinical and radiologic parameters were reviewed. Lateral condylar prominence index (LCPI) and any other complications were evaluated.

Results:
The mean preoperative humerus-elbow-wrist angle (HEWA) on the affected side was 20.9 degrees of varus, which was significantly improved to 9.2 degrees of valgus postoperatively. The mean postoperative value of LCPI was −0.047. Postoperative LCPI and HEWA was compared with the normal side, and there was no significant difference. All of the patients had excellent clinical and radiographic alignment. No surgical complications and limitation of range of motion were noted. No patient complained of lateral bony prominence.

Conclusion:
Lateral closing wedge osteotomy by centralization of distal fragment is a safe and highly effective method and prevents lateral prominence with a minimal complication rate. We recommend this technique for the treatment of cubitus varus in children.

Level of Evidence:
Level IV Case series.
Caregiver Experiences Using Orthotic Treatment Options for Developmental Dysplasia of the Hip in Children
Authors: Grzybowski Georgia , Bliven Emily , Wu Luke , Schaeffer Emily K. , Gibbard Marissa , Zomar Bryn O. , Casagrande Cesconetto Alice , Mundy Claire , Mulpuri Kishore ,   International Hip Dysplasia Registry Knowledge Translation Advisory Board
Published: January 2023

Background:
Developmental dysplasia of the hip (DDH) is a common condition affecting 5 in 1000 newborns. The standard first line of treatment is the use of an orthotic, which has generally high success rates, but can pose substantial difficulties and put undue burden on caregivers. The general experience of caregivers using these orthotics has not been well documented on an orthotic-specific basis. The purpose of this study was to investigate caregiver experience using prescribed DDH orthotics to identify challenges, differences between treatment options, and areas of improvement.

Methods:
A survey assessing treatment prescription, respondent demographics, and caregiver experience was distributed online to caregivers whose child/children were treated for DDH with an orthotic. Seven-point positively phrased Likert scale statements and open-ended questions were included to assess caregiver experience. The results were analyzed using summary statistics and orthotics with more than 30 responses were selected for more in-depth analysis.

Results:
A total of 530 survey responses were collected with 63% (334/530) of respondents using a Pavlik harness, 45% (236/530) a Rhino brace, and 13% (67/530) a Denis Browne Bar. The overall weighted average score across all Likert Scale statements was positive for the Pavlik harness, Rhino brace, and Denis Browne Bar at 4.19 (95% CI, 3.83 to 4.54), 4.63 (95% CI, 4.27 to 4.99) and 4.91 (95% CI, 4.58 to 5.24), respectively. In the open-ended responses, all 3 orthotics were perceived as easy to use and not hindering child-caregiver bonding, but raised concerns of discomfort and skin irritation, as well as preventing the ability to cuddle their child the way they desired. The Pavlik harness respondents consistently brought up concerns regarding cleanability.

Conclusions:
The results show that the DDH orthotics analyzed are generally easy to use and perceived positively by caregivers, but have orthotic-specific challenges that should be a focus of future improvement work.

Clinical Relevance:
This study evaluated opinions and attitudes of caregivers for children being treated with DDH orthotics, revealing experiences, concerns, and challenges associated with the use of commonly prescribed options.
Anterior Cervical Discectomy and Fusion in the Ambulatory Surgery Center Versus Inpatient Setting: One-Year Cost-Utility Analysis
Authors: Monk Steve H. , Hani Ummey , Pfortmiller Deborah , Smith Mark D. , Kim Paul K. , Bohl Michael A. , Coric Domagoj , Adamson Tim E. , Holland Christopher M. , McGirt Matthew J. 
Published: January 2023

Study Design.
Retrospective analysis of prospectively collected data.

Objective.
Assess the cost-utility of anterior cervical discectomy and fusion (ACDF) performed in the ambulatory surgery center (ASC) versus inpatient hospital setting for Medicare and privately insured patients at one-year follow-up.

Summary of Background Data.
Outpatient ACDF has gained popularity due to improved safety and reduced costs. Formal cost-utility studies for ambulatory versus inpatient ACDF are lacking, precluding an accurate assessment of cost-effectiveness.

Materials and Methods.
A total of 6504 patients enrolled in the Quality Outcomes Database (QOD) undergoing one-level to two-level ACDF at a single ASC (520) or the inpatient hospital setting (5984) were compared. Propensity matching generated 748 patients for analysis (374 per cohort). Demographic data, resource utilization, patient-reported outcome measures, and quality-adjusted life-years (QALYs) were assessed. Direct costs (1-year resource use×unit costs based on Medicare national allowable payment amounts) and indirect costs (missed workdays×average US daily wage) were recorded. Incremental cost-effectiveness ratios were calculated.

Results.
Complication rates and improvements in patient-reported outcome measures and QALYs were similar between groups. Ambulatory ACDF was associated with significantly lower total costs at 1 year for Medicare ($5879.46) and privately insured ($12,873.97) patients, respectively. The incremental cost-effectiveness ratios for inpatient ACDF was $3,674,662 and $8,046,231 for Medicare and privately insured patients, respectively, reflecting unacceptably poor cost-utility.

Conclusion.
Inpatient ACDF is associated with significant increases in total costs compared to the ASC setting without a safety, outcome, or QALY benefit. The ASC setting is a dominant option from a health economy perspective for first-time one-l to two-level ACDF in select patients compared to the inpatient hospital setting.
Hyperbaric Oxygen Treatment in Spinal Cord Injury Recovery: Profiling Long Noncoding RNAs
Authors: Liu Xuehua , Liang Fang , Sun Zhencheng , Yang Jing , Su Qingjun 
Published: January 2023

Study Design.
A functional, transcriptome, and long noncoding RNAs (lncRNAs) expression analysis in the spinal cord of mice after hyperbaric oxygen (HBO) treatment.

Objective.
We aimed to explore the mechanism by which HBO treats spinal cord injury (SCI) at the level of lncRNAs.

Summary of Background Data.
Immense amounts of research have established that HBO treatment promotes the recovery of neurological function after SCI. The mechanism of action remains to be clarified.

Methods.
High-throughput RNA sequencing, Gene Ontology, and Kyoto Encyclopedia of Genes and Genomes enrichment analysis were used to profile lncRNA expression and analyze biological function in the spinal cords of mice from sham-operated, SCI, and HBO-treated groups. The differential expression of lncRNA between the groups was assessed using real-time quantitative polymerase chain reaction.

Results.
Differential expression across 577 lncRNAs was identified among the three groups. GO analysis showed that free ubiquitin chain polymerization, ubiquitin homeostasis, DNA replication, synthesis of RNA primer, single-stranded telomeric DNA binding, and alpha-amylase activity were significantly enriched. Kyoto Encyclopedia of Genes and Genomes enrichment analysis displayed that vitamin B6 metabolism, one carbon pool by folate, DNA replication, lysine degradation, beta-alanine metabolism, fanconi anemia pathway, and Notch signal pathway were the main pathways with enrichment significance. LncRNAs NONMMUT 092674.1, NONMMUT042986.2, and NONMMUT018850.2 showed significantly different expression between the SCI and the other two groups (P<0.05, <0.01).

Conclusions.
This study is the first to determine the expression profiles of lncRNAs in the injured spinal cord after HBO treatment. We identified several important dysregulated lncRNAs in this setting. These results help us better understand the mechanism by which HBO treats SCI and provide new potential therapeutic targets for SCI.
Novel strategies to improve efficacy of treatment with tumor-infiltrating lymphocytes (TILs) for patients with solid cancers
Authors: Tas Liselotte , Jedema Inge , Haanen John B.A.G. 
Published: January 2023

Purpose of review
Treatment with tumor-infiltrating lymphocytes (TILs) has shown remarkable clinical responses in patients with advanced solid tumors. Although the TIL production process is very robust, the original protocol stems from the early nineties and lacks effective selection for tumor-reactivity and functional activity. In this review we highlight the limitations of the current production process and give an overview of improvements that can be made to increase TIL efficacy.

Recent findings
With the recent advances in single cell sequencing technologies, our understanding of the composition and phenotype of TILs in the tumor micro environment has majorly increased, which forms the basis for the development of new strategies to improve the TIL production process. Strategies involve selection for neoantigen-reactive TILs by cell sorting or selective expansion strategies. Furthermore, gene editing strategies like Clustered regularly interspaced short palindromic repeats-Cas (CRISPR-Cas9) can be used to increase TIL functionality.

Summary
Although combining all the possible improvements into a next generation TIL product might be challenging, it is highly likely that those techniques will increase the clinical value of TIL therapy in the coming years.