bluuebunny/crossref_metadata_2025_split huggingface dataset:
COVID-19 Vaccine Acceptance among Pregnant Women Attending Antenatal Clinic in a Tertiary Care Hospital of India
Authors: Samanta Sampriti , Bandyopadhyay Alapan , Bhattacherjee Sharmistha , Dasgupta Pallabi 
Published: August 2023

Background:
Despite opinions regarding safety and efficacy of COVID-19 vaccines in pregnancy, they are approved for pregnant women. However, little is known about attitudes and perception of pregnant women toward COVID-19 vaccination.

Objective:
To find out COVID-19 vaccine acceptance, its predictors, and perceptions, among pregnant women attending antenatal clinic in a tertiary care hospital of India.

Methodology:
A descriptive cross-sectional study was conducted among 180 pregnant women during 2021 using a predesigned, pretested questionnaire consisting of vaccination, obstetric history, and perception about COVID-19 vaccination. Those who took at least one dose of vaccine was considered vaccine acceptor. Chi-square test was performed to check association with independent variables for vaccine-acceptors and nonacceptors.

Results:
About 126 (70%) women were vaccine-acceptors and 54 (30%) were nonacceptors. Higher proportion of vaccine-acceptors were noted among those aged >20 years (P = 0.003), with previous pregnancy loss (83.3%) and problem in conceiving (71.4%), working mothers (72.7%), lower socioeconomic status (71.1%), and lower literacy (71.2%). Favorable attitudes toward COVID vaccine were present in most of the participants (72.8%). 74.6% of vaccine acceptors and 61.1% nonacceptors agreed to take vaccine on recommendation of health-care provider (P = 0.009). Significantly higher proportion of acceptors (43.7%) agreed to recommend another mother to take vaccine than nonacceptors (24.1%) (P=- 0.044). Significantly higher proportion of acceptors (84.9%) agreed to get vaccinated with precautionary dose if vaccination camp is organized (P = 0.039).

Conclusion:
A high level of vaccine acceptance was seen mostly because of the trust on health-care providers. Targeted efforts are required for health-care workers and public regarding vaccine literacy.
Thyroid Receptor Antibodies and Thyroid Peroxidase Antibodies in a Sample Thyrotoxic Patients: A Cross-Sectional Study
Authors: Mahdi Bahaa Abbas , Ashoor Zainab Fadhel , Salman Issam Noori 
Published: August 2023

Background:
Thyrotoxicosis is a clinical status due to hypersecretion of thyroid hormones by diffuse goiter (Grave’s disease [GD]), multinodular goiter, single toxic adenoma, and pituitary adenoma secreting thyroid-stimulating hormone (TSH) rarely. GD: It is diffuse toxic goiter (GD) or (Basedow disease) it is a triad of: Diffuse toxic goiter, hyperthyroidism, and exophthalmos (proptosis).

Aims:
1. Positivity of TRAb and TPO in thyrotoxic subjects. 2. Correlation of the titer of these antibodies with the clinical status of the patients. 3. Correlation between TRAb and TPO titer. 4. To find out if TPO titer on enrollment has any correlation with the clinical status of the patients.

Methods:
A cross-sectional study conducted in the National Diabetes Center–Mustansiriyah University in the period from November 2021 to April 2022 where 93 patients with GD are enrolled to check their thyroid status and check some biochemical variables in their sera as thyrotropin receptor antibody (TRAB), thyroid peroxidase (TPO) antibody, TSH, and free thyroxine (FT4). 44.6% are women and 35.7% are men, at the time of recreuitment 49.4% are toxic while the remaining 58.6% are euthyroid being on anti thyroid drugs. 87 persons are recruited as normal euthyroid, they are sex and age-matched, the control TRAb were negative.

Results:
GD patients are as follows: 54 (58.06%) euthyroid and 39 (41.94%) toxic at the time of recruitment. Eighty-two percent of toxic patients have goiter and 74.07% of euthyroid GD patients have goiter. Ophthalmopathy is found in (64.1% of toxic GD patients and 42.59% of euthyroid GD patients. TPO median in the control, toxic, and euthyroid GD patients is (22.76%), (75%) and (63.5%) (highest among toxic GD patients) (P < 0.001). TSH in the control group has a mean of (2.18 ± 1.72) and a median of (1.89). The TRAb is the highest in toxic GD patients, followed by euthyroid GD patients and the least in the control, its mean is (9.98 ± 8.42), (7.24 ± 7.8) and (0.93 ± 0.15), respectively. It is recommended to conduct a longitudinal study in which patients with GD are checked at variables times in the course of illness (remission and relapse) studying these biochemical and immunological markers in these variable states of thyroid function.

Conclusion:
Ninety-three thyrotoxic patients, 39 are toxic and 54 are euthyroid on arrival. Eye sings are more in toxic patients, goiter and eye signs are predictor of GD, TRAb is the highest among toxic patients, TPO are higher among GD patients versus the control.
Effect of Toxoplasma gondii on the Expression of Cytotoxic T-Lymphocyte-Associated Protein 4 in Women with Toxoplasmosis
Authors: Sultan Sura Abbas , Al-Kuraishi Azhar Hatif , Mahdi Ali Abdul Hussein 
Published: August 2023

Background:
Toxoplasmosis is a disease caused by an obligatory intracellular protozoan parasite (Toxoplasma gondii). Cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) is a protein receptor that acts as an immunological checkpoint and reduces immune responses.

Aims:
The present study aimed to evaluate the expression of CTLA-4 protein in women with different toxoplasmosis stages and observed its role in the occurrence of abortion.

Materials and Methods:
Anti-Toxoplasma immunoglobulin M (IgM) and IgG antibodies were detected by enzyme-linked immunosorbent assay (ELISA) test in the sera of 116 patients with toxoplasmosis (46 aborted infected groups, 35 pregnant infected groups, and 35 married infected groups). Furthermore, this test was done for 70 control samples (35 aborted women without toxoplasmosis infection and 35 healthy women). As a final point, all samples were examined to measure the level of CTLA-4 using ELISA kits (MyBioSource. Com., Ltd., USA).

Results:
Results showed that a higher level of CTLA-4 was seen in the aborted women group 34 (73.9%) than in other infected groups, and the highest CTLA-4 levels were seen in IgG positive, 20 (43.47%) of 46 in the same group, than other types of antibodies. Furthermore, the highest concentration (948.2 ± 269.4 ng/ml) was indicated in the same group and type of antibodies, with a cutoff value of 597.0 ng/ml (71.7% sensitivity and 97.1% specificity).

Conclusions:
It can be concluded that the CTLA-4 level can be used as a predicted and supported factor for the occurrence of abortion in women infected with toxoplasmosis, especially in the chronic type of the disease (IgG-positive) with a cutoff value of 597.0 ng/ml with 71.7% sensitivity and 97.1% specificity.
Effect of Celecoxib Alone or in Combination of Sitagliptin in Monoiodoacetate Rat Model of Osteoarthritis
Authors: Al-Uqabi Rabab Utba , Al-Gareeb Ali I. , Al-Buhadily Ali K. 
Published: August 2023

Background:
Osteoarthritis (OA) is considered an attractive research issue; as it is the most common musculoskeletal progressive condition with no cure yet.

Aims:
To evaluate effect of celecoxib alone or in combination of sitagliptin in monoiodo acetate rat model of OA.

Methods:
A total of 40 Sprague-Dawley male rats were divided into 4 groups, negative control (n=10), positive control group (OA induced by monoiodoacetate (MIA)) (n=10), celecoxib 50mg/kg (n=10), and celecoxib 50mg/kg plus sitagliptin 20mg/kg group (n=10). Serum levels of inflammatory biomarkers and serum CTX-II were assessed for all groups. Data were analyzed statistically by SPSS version 28.00.

Results:
group treated with celecoxib showed a significant reduction in the inflammatory biomarkers and CTX-II serum levels compared with the OA group (P<0.01). A significant reduction in CTX-II level in combination treated group relative to celecoxib treated group.

Conclusion:
Celecoxib imparted anti-inflammatory and cartilage protective effect in OA induced rat model. Sitagliptin combination with celecoxib added an extra cartilage protective effect by reducing cartilage degradation evident by lowering CTX-II serum levels.
Dimensions of the Sphenoid and Ethmoid Sinuses on Computed Tomography: Clinical Implications and Role in Sex Determination
Authors: Ominde Beryl Shitandi , Ikubor Joyce Ekeme , Iju Wilson Josiah , Igbigbi Patrick Sunday 
Published: August 2023

Background:
The measurements of the sphenoid and ethmoid sinuses (ESs) are essential in forensic investigations and during endoscopic sinus and skull base surgeries. This study aimed at assessing the dimensions of these sinuses and elucidating their role in sex determination.

Materials and Methods:
This retrospective assessment was conducted using brain-computed tomographic images stored in the Department of Radiology in a Tertiary hospital in Delta State, Nigeria. After institutional ethical approval, images of 292 patients (115 females and 177 males) aged >20 years, were used to measure the dimensions of the ethmoid and sphenoid sinuses (SSs) bilaterally. These were analyzed and summarized using descriptive statistics. Their association with gender, side, or age was assessed using inferential statistics and considered statistically significant at P < 0.05. Discriminant function analysis of the sinus measurements was conducted to evaluate their accuracy in correct sex prediction.

Results:
Both sphenoid and ESs showed significant sexual dimorphism. The ESs showed significant asymmetry (P < 0.05). The anterior width of the left ES (79.8%) was the best sex-discriminating variable. The combination of the left sinus dimensions was more accurate (74.3%, 85.3%) than the right sinuses (72.6%, 81.2%) in sex allocation. Using the bilateral ES dimensions yielded a higher accuracy (89.0%) than using bilateral SS parameters (80.1%).

Conclusion:
The sphenoid and ESs may be used in predicting the sex of an unknown skull bone recovered within the studied population with acceptable accuracy levels.
Killing Efficiency and Full Genome Sequencing of Bacteriophage BAG1 Targeting Endodontic Clinical Strain of Enterococcus faecalis
Authors: Almelan Maha F. , Abbas Uroba Khalid , Al-Zubidi M. 
Published: August 2023

Objectives:
Bacterial biofilms can increase the survival of bacteria through providing resistance to conventional disinfectants as well as antibiotics, thus biofilm considered a serious risk to human health with hug loss. Consequently, novel approaches to deal with bacterial biofilms are required. Viruses that may eradicate bacteria are known as bacteriophages, they are also known as “bacteria eaters.” Due to their activity on bacteria, bacteriophages are distinct from other organisms and do not pose a threat to human. Consequently, they are regarded as secure substitutes for antibiotics in the management of bacterial infections.

Aim of the Study:
In this study, we report the full genome sequencing of bacteriophage, namely BAG1 that targeting an endodontic clinical strain of Enterococcus faecalis (K3). Furthermore, we evaluate it killing efficiency to eliminate E. faecalis in both planktonic media and dentine slabs.

Materials and Methods:
We used the previously isolated endodontic E. faecalis clinical strain, namely K3 and enterococcus bacteriophage BAG1 in this study by spotting on the double layer agar technique. DNA extracted proceeded with NORGEN phage DNA isolation kit. Phage full genome sequencing was performed using Illumina nova Seq 600, 150 bp PE. In addition, the killing capacity of BAG1 phage against E. faecalis K3 was measured by infecting 5 × 106
E. faecalis with BAG1 phage at multiplicity of infection of 0.1. Furthermore, the biofilm fraction and the number of E. faecalis colony-forming unit in planktonic media were measured after infecting 24 dentine slabs with K3 bacteria and BAG1 phage. SYTO® 9 green LIVE/DEAD® BacLight Bacterial Viability Kits were used to visualize K3 biofilm on dentine slabs using fluorescent microscope.

Results:
Full Genome Organization of BAG1 phage was circular composed of 68 open reading frame with GC percentage of 34.56%. An efficient killer reflecting by completely eliminating K3 strain within 180 min in killing test. In addition, the result revealed that BAG1 highly significant to eliminate K3 bacteria in both planktonic broth and biofilm fraction obtained from dentine slabs infection with the endodontic K3 clinical strain.

Conclusion:
Our results support that anti E. faecalis bacteriophage BAG1 significantly eliminate biofilm of E. faecalis K3 on dentine slabs with a lytic properties due to the absence of lysogenic genes which make it a suitable substitute to adjunctive anti E. faecalis therapy.
Mutation Status Defines Subtypes of Essential Thrombocythemia and Relation to Polycythemia Vera in Iraqi Patients
Authors: Al Dayyeni Aseel Modhfer , Al-Gailani Bassam T. , Mahdi Mohammed Ghanim 
Published: August 2023

Background:
Polycythemia vera (PV) and essential thrombocythemia (ET) are a part of the BCR-ABL1-negative myeloproliferative neoplasms (MPNs) that harbor mutation in Janus kinase 2 (JAK2), CALR, or MPL gene.

Objectives:
The objective of this study was to investigate the impact of JAK2 and CALR mutations on the clinical course and hematological phenotype of ET patients and to evaluate the biological and clinical features of ET and PV sharing the same type of mutation in JAK2V617F.

Materials and Methods:
This was a cross-sectional study that included 94 patients diagnosed with MPN, of them 47 had PV and 47 had ET. JAK2V617F mutation was assessed using either allele-specific PCR or JAK-2 quantitative real-time PCR kit. JAK2-negative patients were further assessed for the existence of CALR mutations using SNP biotechnology MPN screening kit.

Results:
JAK2 mutation was identified in 29 ET patients, whereas CALR mutations were confirmed in 18 patients. JAK2-mutated ET patients were significantly older than those with CALR mutations. Seventy-six were reported to have a mutation in JAKV617F, of them 47 were diagnosed as PV and 29 as ET. JAK2V617F-mutated PV patients had significantly higher levels of hemoglobin, hematocrit, and WBC than JAK2-mutated ET patients. On the other hand, JAK2-mutated PV patients exhibited lower platelet count than ET harboring the same mutation.

Conclusion:
JAK2-mutated ET represents a distinct clinical entity that has a hematological and clinical phenotype ranging between JAK2-mutated PV and CALR-mutated ET. The analysis of the mutational status is essential in discriminating subtypes of MPN and confirming the diagnosis in ET and PV patients.
ANALISIS KELAYAKAN BUKU TEKS SISWA IPA KURIKULUM 2013 PADA MATERI PENCEMARAN LINGKUNGAN KELAS VII DITINJAU DARI KELENGKAPAN DAN KETEPATAN ISI
Authors: Yusa Ilham Widia , Septiana Eriza Ika , Susanti Ariska Putri 
Published: August 2023

This study aims to identify the completeness and accuracy of the contents of the 2013 curriculum science student textbooks on environmental pollution material in grade VII. The method used in this research is a qualitative approach. From the results of the analysis, it was found that the completeness of the contents of the 2013 curriculum science student textbook on environmental pollution material for grade VII was considered incomplete, this was due to the fact that there were still some sub-materials that had not been included. As for the accuracy of the contents of the book, it can be said that it is quite in accordance with the indicators of KD achievement from KI-1, KI-2, KI-3 and KI-4. This is evidenced by the suitability of the content of the book which is sufficient to meet the KD achievement indicators from KI. Based on the results of the analysis, it can be said that the student textbook is feasible as teaching material but still requires improvement. Keywords: Student Textbooks, Completeness of Content, Accuracy of Content, Teaching Materials, 2013 Curriculum
RESPON SISWA TERHADAP PENGGUNAAN MEDIA KOMIK DALAM PEMBELAJARAN IPA MATERI LISTRIK STATIS SISTEM DARING
Authors: Erawati Fera , Munirotuzzakiyah Munirotuzzakiyah , Haqiqi Arghob Khofya 
Published: August 2023

This study aims to determine the response of students to the use of comic media in science learning with static electricity material which the authors expect to get a positive response from students and can help reduce student boredom in science learning using comic media. By making media that is fun and does not make students bored, students will be more enthusiastic in learning and the learning process can take place well without any complaints from students who feel bored by only using written media. Material static electricity is one of the branches of physics material that is important for students to understand. By using comic book media in delivering static electricity with a few pictures, it can reduce student boredom and it will be more fun than just writing. This research method uses a qualitative method by surveying the opinions of several students in different schools regarding the use of comic media on online system static electricity material using the whats app group. The results of the study showed that many students were interested in the use of comic media compared to only using writing in science learning with static electricity in online systems. Keywords: student responses, comic media, science learning, static electricity, online
Metode Topsis Pada Sistem Pendukung Keputusan Penilaian Kinerja Karyawan Untuk Kenaikan Jabatan
Authors: Katarina Sianturi Susy , Sutopo Teguh , Zakaria Zakaria 
Published: August 2023

Penelitian ini dilatarbelakangi adanya Masalah pada saat proses penilain kinerja karyawan pada PT.Sentra Karya Mandiri ada hal yang kurang tepat, seperti penilaian yang masih menggunakan hitung-hitungan yang masih kurang efektif, dan dinilai kurang ideal, bahkan sesekali ada perhitungan yang dilakukan antara beberapa kandidat yang cukup sulit untuk dibandingkan. oleh sebab itu dibutuhkan sebuah sistem perhitungan yang lebih ideal untuk menunjang keputusan yang akan diambil dengan cara membuat sebuah sistem penunjang keputusan. Penelitian ini menggunakan SPK metode Technique For Order Preference by Similarity to Ideal Solution (TOPSIS) dimana data yang ada diperoleh penulis dari PT. Sentra Karya Mandiri dengan cara observasi langsung dan wawancara secara langsung dengan karyawan dan bagian terkait. Penelitian ini bertujuan mempermudah penilaian kinerja karyawan untuk kenaikan jabatan dengan menggunakan SPK metode TOPSIS, dan merancang dan membuat aplikasi yang dapat digunakan oleh PT. Sentra Karya Mandiri untuk menunjang kelancaran kegiatan penilaian kinerja karyawan. Berdasarkan studi literatur, observasi, dan wawancara tersebut diperoleh 5 kriteria (Disiplin, Sikap, Keterampilan, Inisiatif, dan Kualitas Kerja). Hasil dari penelitian ini menghasilkan aplikasi yang memenuhi tujuan dan proses penentuan karyawan terbaik bisa menjadi lebih akurat, efektif dan efisien dalam menghasilkan perhitungan yang dapat digunakan sebagai pendukung keputusan oleh PT. Sentra Karya Mandiri.
SISTEM PENCATATAN KEUANGAN SEKOLAH BERBASIS VB.NET (STUDI KASUS: MTS NU UNGARAN KABUPATEN SEMARANG)
Authors: Khusnul Khotimah Isnaini , Sumarlin Tantik , Rakasiwi Sindhu 
Published: August 2023

Pendidikan merupakan faktor terbesar untuk kemajuan suatu bangsa. Disini peranan teknologi informasi sangat diperlukan dengan semakin berkembangnya suatu lembaga pendidikan, bertambahnya siswa dan ilmu pengetahuan serta kualitas sumber daya manusia yang ada. Lembaga yang baik tentunya harus memiliki sistem informasi. Hampir semua lembaga pendidikan telah menggunakan sistem informasi untuk mempermudah segala kegiatan yang ada di dalamnya. MTs NU Ungaran merupakan salah satu Madrasah Tsanawiyah swasta yang terletak di Jl. Kaligarang No.09, Kecamatan Ungaran Barat, Kabupaten Semarang. Selama ini, dalam proses pencatatan pembayaran SPP di MTs NU Ungaran masih menggunakan sistem manual, akibatnya proses pencatatan pembayaran SPP masih tidak efektif dan efisien. Banyak sekali kesalahan proses dalam pencatatan, misalnya dalam peginputan nama siswa, nominal pembayaran, dan hal lainnya. Semakin berkembangnya suatu lembaga pendidikan dan mengikuti perkembangan era digital, Madrasah tersebut akan menerapkan sistem informasi dalam proses kegiatan, dengan cara melakukan praktek langsung terhadap permasalahan yang terjadi. Oleh karena itu, penulis merancang sebuah sistem khusus yang digunakan untuk pencatatan pembayaran SPP. Yaitu sistem informasi berbasis multiuser dengan bahasa pemrograman Vb.Net untuk mempermudah pembuatan aplikasi tersebut, karena memiliki keunggulan mudah dikembangkan, fleksibel, dan akses informasi lebih mudah.

Penulis berharap dengan adanya Sistem Informasi Pencatatan Pembayaran SPP ini dapat mengurangi kesalahan-kesalahan yang mungkin terjadi serta dilakukan dengan lebih akurat dan efisien oleh staff admin di MTs NU Ungaran
SISTEM INFORMASI AKUNTANSI ANGGARAN LABA DENGAN METODE A POSTERIORI
Authors: Wahyuning Sri , Rachmawati Nur , Sumaryanto  
Published: August 2023

Information technology can be used in various human lives, one of which is in the business field. In today's era, it is undeniable that computers with accounting information system equipment are components that must be owned by companies to help ease the task of company performance. One of them is BKM which is specifically aimed at poverty alleviation and community development. UPK itself is a non-profit organization or an organization whose main objective is to support an issue or matter in attracting public attention for a non-commercial purpose, without any attention to things that are for-profit. The allocation has also been divided according to their respective portions.
This study aims to simplify the presentation of profit budgeting at BKM which is still not structured and does not provide clarity about the results of the funds that should be used as the allocation of community activities. Profit budgeting is also not carried out periodically and is still manual in recording so that profits cannot be known in detail. In overcoming the problems above, by using a programmed system with the a posteriori method, the institution can easily record every operational budget to the profit budget so that it can allocate funds for community activities in a structured manner