bluuebunny/crossref_metadata_2025_split huggingface dataset:
OncoCardioDB: a public and curated database of molecular information in onco-cardiology/cardio-oncology
Authors: Riffo-Campos Angela L , Domingo Juan , Dura Esther 
Published: May 2023

Abstract
Numerous studies have been published which, separately, investigate the influence of molecular features on oncological and cardiac pathologies. Nevertheless, the relationship between both families of diseases at the molecular level is an emerging area within onco-cardiology/cardio-oncology. This paper presents a new open-source database that aims to organize the curated information concerning the molecular features validated in patients involved in both cancer and cardiovascular diseases. Entities like gene, variation, drug, study and others are modelled as objects of a database which is populated with curated information from 83 papers identified by systematic literature searched for up to 2021. Researchers will discover new connections among them to validate hypotheses or suggest new ones. Special care has been taken to use standard nomenclature for genes, pathologies and all the objects for which accepted conventions exist. The database can be consulted via the web with a system of simplified queries, but it also accepts any query. It will be updated and refined with the incorporation of new studies as they become available.
Database URL http://biodb.uv.es/oncocardio/
Soil microbial communities are sensitive to differences in fertilization intensity in organic and conventional farming systems
Authors: Lori Martina , Hartmann Martin , Kundel Dominika , Mayer Jochen , Mueller Ralf C , Mäder Paul , Krause Hans-Martin 
Published: May 2023

AbstractIntensive agriculture has increased global food production, but also impaired ecosystem services and soil biodiversity. Organic fertilization, essential to organic and integrated farming, can provide numerous benefits for soil quality but also compromise the environment by polluting soils and producing greenhouse gases through animal husbandry. The need for reduced stocking density is inevitably accompanied by lower FYM inputs, but little research is available on the impact of these effects on the soil microbiome. We collected soil samples from winter wheat plots of a 42-year-old long-term trial comparing different farming systems receiving farmyard manure at two intensities and measured soil quality parameters and microbial community diversity through DNA metabarcoding. High-input fertilization, corresponding to 1.4 livestock units (LU) improved the soil’s nutritional status and increased soil microbial biomass and respiration when compared to low-input at 0.7 LU. Bacterial and fungal α-diversity was largely unaffected by fertilization intensity, whereas their community structure changed consistently, accompanied by an increase in the bacterial copiotroph-to-oligotroph ratio in high-input systems and by more copiotrophic indicator OTUs associated with high than low-input. This study shows that reduced nutrient availability under low-input selects oligotrophic microbes efficiently obtaining nutrients from various carbon sources; a potentially beneficial trait considering future agroecosystems.
Message fatigue beyond the health message context: a replication and further extension of So et al. (2017)
Authors: Song Hyunjin , So Jiyeon 
Published: May 2023

Abstract
Repeated exposure to similar messages may be counterproductive, yet the majority of the extant research tends to neglect this possibility. Addressing this issue, So et al. (2017) conceptualized and operationalized the message fatigue construct within the health message context. We replicate their study in a climate change message context and extend their work by proposing and validating a shortened message fatigue scale. The results of a preregistered study (N = 620) show that the conceptual structure and correlates of message fatigue are well replicated: Climate change message fatigue retains the original factor structure, and it is positively correlated with counterargument and negatively correlated with attention and message elaboration. Moreover, their relationships with message fatigue are shown to be moderated by political ideology in a theoretically expected manner. The shortened message fatigue scale also exhibits adequate psychometric properties, offering a less cumbersome alternative to the original scale.
CmWRKY6–1–CmWRKY15-like transcriptional cascade negatively regulates the resistance to fusarium oxysporum infection in Chrysanthemum morifolium
Authors: Miao Weihao , Xiao Xiangyu , Wang Yuean , Ge Lijiao , Yang Yanrong , Liu Ye , Liao Yuan , Guan Zhiyong , Chen Sumei , Fang Weimin , Chen Fadi , Zhao Shuang 
Published: May 2023

Abstract
Chrysanthemum Fusarium wilt is a soil-borne disease that causes serious economic losses to the chrysanthemum industry. However, the molecular mechanism underlying the response of chrysanthemum WRKY to Fusarium oxysporum infection remains largely unknown. In this study, we isolated CmWRKY6–1 from chrysanthemum ‘Jinba’ and identified it as a transcriptional repressor localized in the nucleus via subcellular localization and transcriptional activation assays. We found that CmWRKY6–1 negatively regulated resistance to F. oxysporum and affected reactive oxygen species (ROS) and salicylic acid (SA) pathways using transgenic experiments and transcriptomic analysis. Moreover, CmWRKY6–1 bound to the W-box element on the CmWRKY15-like promoter and inhibited its expression. Additionally, we observed that CmWRKY15-like silencing in chrysanthemum reduced its resistance to F. oxysporum via transgenic experiments. In conclusion, we revealed the mechanism underlying the CmWRKY6–1–CmWRKY15-like cascade response to F. oxysporum infection in chrysanthemum and demonstrated that CmWRKY6–1 and CmWRKY15-like regulates the immune system.
Surgical technique for preventing lung torsion after right upper and lower bilobectomy
Authors: Eriguchi Daisuke , Imai Kentaro , Kajiwara Naohiro , Ikeda Norihiko 
Published: May 2023

Abstract
In cases of right upper and lower bilobectomy, careful manipulation is required to avoid lung torsion, as only the right middle lobe remains in the right thoracic cavity. We report a case of successful right upper and lower bilobectomy with no torsion of the middle lobe. Our technique prevents postoperative lung torsion by fixing the lung to the chest wall and pericardial fat with silk threads. In situations where lung torsion is a concern after lung resection, fixing the remaining lungs with silk thread is effective in preventing lung torsion.
Improving thermal performance of a ventilated tiled roof by using phase change materials
Authors: Bottarelli Michele , Baccega Eleonora , Gallero Francisco Javier González , Maestre Ismael Rodríguez , Pei Gang , Su Yuehong 
Published: May 2023

Abstract
The adoption of ventilated roofs and facades, as well as the integration of phase change materials (PCMs) in the building envelope, has proved to be effective as a passive cooling technique in reducing the solar heat gain through the building envelope during the summer period, therefore reducing the energy requirement for cooling. Even though much research focused on each of these strategies individually, their combination has not been deeply studied yet. Preliminary numerical studies were carried out on the application of PCMs on a pitched ventilated tiled roof, and the most effective position turned out to be the one suspended in the middle of the above sheathing ventilation (ASV) channel. Based on this conclusion and exploiting an existing mock-up facility, two equivalent pitched ventilated roofs with an air gap of 4 cm were built as coverage of two identical rooms, each one equipped with a fan coil, one with a 0.007-m PCM layer suspended in the middle of the ASV and the other one without. They were then tested under real conditions at the TekneHub Laboratory at the University of Ferrara. The behaviour of the two configurations were compared in terms of temperature, velocity of the air in the ASV, heat flux and energy requirement for cooling, which were monitored through T-type thermocouples, heat flow metre, anemometers and energy metres, respectively. The aim of the research was to validate the numerical results and confirm that the combination of the two strategies allows further improvement of roof performance.
Euler simulation of interacting particle systems and McKean–Vlasov SDEs with fully super-linear growth drifts in space and interaction
Authors: Chen Xingyuan , dos Reis Gonçalo 
Published: May 2023

Abstract
This work addresses the convergence of a split-step Euler type scheme (SSM) for the numerical simulation of interacting particle Stochastic Differential Equation (SDE) systems and McKean–Vlasov stochastic differential equations (MV-SDEs) with full super-linear growth in the spatial and the interaction component in the drift, and nonconstant Lipschitz diffusion coefficient. Super-linearity is understood in the sense that functions are assumed to behave polynomially, but also satisfy a so-called one-sided Lipschitz condition. The super-linear growth in the interaction (or measure) component stems from convolution operations with super-linear growth functions, allowing in particular application to the granular media equation with multi-well confining potentials. From a methodological point of view, we avoid altogether functional inequality arguments (as we allow for nonconstant nonbounded diffusion maps). The scheme attains, in stepsize, a near-optimal classical (path-space) root mean-square error rate of $1/2-\varepsilon $ for $\varepsilon&gt;0$ and an optimal rate $1/2$ in the nonpath-space (pointwise) mean-square error metric. All findings are illustrated by numerical examples. In particular, the testing raises doubts if taming is a suitable methodology for this type of problem (with convolution terms and nonconstant diffusion coefficients).
Wedge Video: Supporting Remote Participants in a Mixed-Mode Videoconference Meeting
Authors: Rogers Bill , Apperley Mark , Reyes Ervin Delos , Masoodian Masood 
Published: May 2023

Abstract
As global COVID-19 pandemic response has moved from full lockdowns and partial lockdowns in most parts of the world to a post-COVID era, an interesting new phenomenon that has emerged is the increased prevalence of hybrid meetings with a mixture of online and in-person attendees. The opportunity for remote participants to observe the responses and interactions of others in the meeting is generally accepted as being limited. An experimental prototype system, called Wedge Video, has been constructed as an attempt to improve the experience of remote participants in hybrid in-person/remote meetings. Wedge Video uses standard screen and camera equipment with existing video conferencing software (Zoom). An evaluation of the prototype system was conducted based on three simple games that each required players to interact rapidly and with some use of body language or gaze direction. Encouraging results led to the examination of the geometry of screen and camera placement in detail. A system that has a somewhat ‘virtual reality’ feeling to it has now been developed. The remote user is given a view of the in-person part of the meeting with participants at the same scale and location as they would be if the remote user were at the table themselves. Similarly, the local participants see the remote person in place at their table, at a realistic scale and with close to accurate gaze direction. A very preliminary evaluation of these concepts has been promising.
Comparison of methods for the effective evaluation of the energy content of poultry byproduct meal for beagles
Authors: Zhang Qiaoru , Sun Haoran , Gao Zuer , Feng Minshan , Zhang Haihua , Zhang Tietao 
Published: May 2023

Abstract
The objectives of this study were to compare the energy values of poultry byproduct meal (PBM) as feed for adult beagle dogs using the direct, difference, and regression methods to examine dogs’ nitrogen metabolism, energy utilization, gaseous metabolism, and body health. Five groups of six 12 mo old female beagles with an average body weight of 9.67 ± 0.52 kg were tested in a 5 × 6 incomplete Latin square design, with six repetitions in each group. Five experimental diets were tested consisting of 100% PBM; three substitution diets containing either 15%, 30%, or 45% PBM (termed 15PBM, 30PBM, and 45PBM, respectively); and a basal diet (included 6.90% PBM). Each experimental period lasted for 10 d, comprising 4 d of dietary acclimation followed by 6 d of testing (including 3 d feeding period and 3 d fasting period), during which the heat production (HP) was determined and feces and urine were collected. Results showed that, in the feeding state, the nitrogen intake, urinary nitrogen, apparent nitrogen digestibility, retained nitrogen, andHP increased significantly (P &lt; 0.05) as the PBM level increased. The net protein utilization, biological value of protein, and total apparent digestibility of amino acids did not differ between the 30PBM and 45PBM diets (P &gt; 0.05). The O2 consumption and CO2 production of beagles during the fasting period were not influenced by the PBM level (P &gt; 0.05). The digestible energy and metabolizable energy values of the PBM estimated by the regression method were 20.16 and 18.18 MJ/kg dry matter (DM), respectively, and did not differ from those determined by the direct method (P &gt; 0.05). The fecal DM percentages and fecal PBM scores were significantly higher in the PBM diet than in the difference method groups (P &lt; 0.05). The direct method group had a significantly higher fecal score (4.63) than the other groups (P &lt; 0.05), The fecal score of the 45PBM diet (3.50) was significantly higher than the 30PBM diet (2.90; P &lt; 0.05). In summary, the direct and difference methods of determining the effective energy value of PBM for beagles, produce significantly different results. Under the conditions of this test, the best proportion of PBM in beagle feed for optimum energy provision is 30%.
Attrition of Well-Healed Burn Survivors to a 6-Month Community-Based Exercise Program: A Retrospective Evaluation
Authors: Atkins Whitley C , Romero Steven A , Moralez Gilbert , Huang Mu , Cramer Matthew N , Foster Josh , McKenna Zachary J , Crandall Craig G 
Published: May 2023

Abstract
The purpose of this study was to evaluate whether burn survivors have lower adherence compared to non-burned control individuals during a 6-month community-based exercise program. In burn survivors, we sought to answer if there was a relation between the size of the burn injury and dropout frequency. Fifty-two burn survivors and 15 non-burned controls (n = 67) were recruited for a 6-month community-based (ie, non-supervised), progressive, exercise training program. During the exercise program, 27% (ie, 4 of the 15 enrolled) of the non-burned individuals dropped out of the study, while 37% (ie, 19 of the 52) of the burn survivors dropped out from the study. There was no difference in the percentage of individuals who dropped out between groups (P = .552). There was no difference in size of the burn injury, expressed as percent body surface area burned (%BSA) between the burn survivors that dropped out versus those who completed the exercise regimen (P = .951). We did not observe a relation between %BSA burned and dropouts (log odds = −0.15–0.01(%BSA), B = −0.01, SE = 0.015, P = .541). There was no effect of %BSA burned on the probability of dropout [Exp (B) = 0.991, 95% CI (0.961, 1.020)] and there were no differences in the percentage of individuals who dropped out of the study based on %BSA burned (χ2(1) = 0.44, P = .51). These data demonstrate that burn survivors have similar exercise adherence relative to a non-burned group and the extent of a burn injury does not affect exercise program adherence.
Stakeholder engagement in the pooled procurement program in Ghana
Authors: Domfeh Kofi Ameyaw , Appiah-Agyekum Nana Nimo 
Published: May 2023

Abstract

Objective
The article explores stakeholders’ engagement before the implementation of the pooled procurement program (PPP) and the challenges encountered by the National Catholic Health Service (NCHS).

Method
The article used a qualitative research approach and a multiple case study design to solicit the views of healthcare service providers and policymakers within the NCHS.

Key findings
The article revealed that the National Catholic Health Secretariat (the secretariat) advocated through the Ghana Catholic Bishops Conference through the bishop responsible for health. Subsequently, the Diocesan Directors, managers, accountants, suppliers and storekeepers of all health facilities were engaged to understand their respective roles before implementing the PPP. The challenges faced came from all institutions that played a crucial role in the smooth running of the PPP. These institutions were the hospitals, suppliers, Food and Drugs Authority (FDA), National Health Insurance Scheme (NHIS) and the secretariat. The findings indicated that some managers in the hospitals were not committed to the program. Whereas, some suppliers purposely weakened the position of some other suppliers after awarding tenders by carrying their commodities directly to the hospitals and reducing the price marginally. The challenge from the NHIS perspective was the payment delays. The FDA was not proactive with post-market surveillance to check substandard commodities in the hospitals. However, in the secretariat, the deficiency was the weak systems to monitor real-time activities of the PPP at the hospitals.

Conclusion
The article suggests that to ensure the right synergies to meet organizational objectives, the NCHS is advised to increasingly focus on identifying and sustaining the PPP by communicating with other stakeholders to achieve their mutual needs. Such a process would allow the more knowledgeable design of resource needs and allocation of scarce resources to their areas of interest.
Raspberry ketone improves non-alcoholic fatty liver disease induced in rats by modulating sphingosine kinase/sphingosine-1-phosphate and toll-like receptor 4 pathways
Authors: Abdelraheem Kareem M , Younis Nahla N , Shaheen Mohamed A , Elswefy Sahar E , Ali Sousou I 
Published: May 2023

Abstract

Objectives
To investigate the therapeutic role of calorie-restricted diet (CR) and raspberry ketone (RK) in non-alcoholic fatty liver disease (NAFLD) and the implication of sphingosine kinase-1 (SphK1)/sphingosine-1-phosphate (S1P) and toll-like receptor 4 (TLR4) signalling.

Methods
NAFLD was induced by feeding rats high-fat-fructose-diet (HFFD) for 6 weeks. Rats were then randomly assigned to three groups (n = 6 each); NAFLD group continued on HFFD for another 8 weeks. CR group was switched to CR diet (25% calorie restriction) for 8 weeks and RK group was switched to normal diet and received RK (55 mg/kg/day; orally) for 8 weeks. Another six rats were used as normal control.

Key findings
HFFD induced a state of NAFLD indicated by increased fat deposition in liver tissue along with dyslipidemia, elevated liver enzymes, oxidative stress and inflammation. Either CR diet or RK reversed these changes and decreased HFFD-induced elevation of hepatic SphK1, S1P, S1PR1 and TLR4. Of notice, RK along with a normal calorie diet was even better than CR alone in most studied parameters.

Conclusions
SphK1/S1P and TLR4 are interconnected and related to the establishment of HFFD-induced NAFLD and can be modulated by RK. Supplementation of RK without calorie restriction to patients with NAFLD unable to follow CR diet to achieve their treatment goals would be a promising therapeutic modality.
The ARF2–MYB6 module mediates auxin-regulated petal expansion in rose
Authors: Chen Changxi , Hussain Nisar , Ma Yanxing , Zuo Lanxin , Jiang Yunhe , Sun Xiaoming , Gao Junping 
Published: May 2023

Abstract
In cut rose (Rosa hybrida), the flower-opening process is closely associated with vase life. Auxin induces the expression of transcription factor genes that function in petal growth via cell expansion. However, the molecular mechanisms underlying the auxin effect during flower opening are not well understood. Here, we identified the auxin-inducible transcription factor gene RhMYB6, whose expression level is high during the early stages of flower opening. Silencing of RhMYB6 delayed flower opening by controlling petal cell expansion through down-regulation of cell expansion-related genes. Furthermore, we demonstrated that the auxin response factor RhARF2 directly interacts with the promoter of RhMYB6 and represses its transcription. Silencing of RhARF2 resulted in larger petal size and delayed petal movement. We also showed that the expression of genes related to ethylene and petal movement showed substantial differences in RhARF2-silenced petals. Our results indicate that auxin-regulated RhARF2 is a critical player that controls flower opening by governing RhMYB6 expression and mediating the crosstalk between auxin and ethylene signaling.
An effector of ‘Candidatus Liberibacter asiaticus’ manipulates autophagy to promote bacterial infection
Authors: Shi Hongwei , Yang Zuhui , Huang Jie , Wu Haodi , Fu Shimin , Li Weimin , Zou Xiuping , Zhou Changyong , Wang Xuefeng 
Published: May 2023

Abstract
Autophagy functions in plant host immunity responses to pathogen infection. The molecular mechanisms and functions used by the citrus Huanglongbing (HLB)-associated intracellular bacterium ‘Candidatus Liberibacter asiaticus’ (CLas) to manipulate autophagy are unknown. We identified a CLas effector, SDE4405 (CLIBASIA_04405), which contributes to HLB progression. ‘Wanjincheng’ orange (Citrus sinensis) transgenic plants expressing SDE4405 promotes CLas proliferation and symptom expression via suppressing host immunity responses. SDE4405 interacts with the ATG8-family of proteins (ATG8s), and their interactions activate autophagy in Nicotiana benthamiana. The occurrence of autophagy is also significantly enhanced in SDE4405-transgenic citrus plants. Interrupting NbATG8s-SDE4405 interaction by silencing of NbATG8c reduces Pseudomonas syringae pv. tomato strain DC3000ΔhopQ1-1 (Pst DC3000ΔhopQ1-1) proliferation in N. benthamiana, and transient overexpression of CsATG8c and SDE4405 in citrus promotes Xanthomonas citri subsp. citri (Xcc) multiplication, suggesting that SDE4405-ATG8s interaction negatively regulates plant defense. These results demonstrate the role of the CLas effector protein in manipulating autophagy, and provide new molecular insights into the interaction between CLas and citrus hosts.
PEP-FOLD4: a pH-dependent force field for peptide structure prediction in aqueous solution
Authors: Rey Julien , Murail Samuel , de Vries Sjoerd , Derreumaux Philippe , Tuffery Pierre 
Published: May 2023

AbstractAccurate and fast structure prediction of peptides of less 40 amino acids in aqueous solution has many biological applications, but their conformations are pH- and salt concentration-dependent. In this work, we present PEP-FOLD4 which goes one step beyond many machine-learning approaches, such as AlphaFold2, TrRosetta and RaptorX. Adding the Debye-Hueckel formalism for charged-charged side chain interactions to a Mie formalism for all intramolecular (backbone and side chain) interactions, PEP-FOLD4, based on a coarse-grained representation of the peptides, performs as well as machine-learning methods on well-structured peptides, but displays significant improvements for poly-charged peptides. PEP-FOLD4 is available at http://bioserv.rpbs.univ-paris-diderot.fr/services/PEP-FOLD4. This server is free and there is no login requirement.