bluuebunny/crossref_metadata_2025_split huggingface dataset:
Uterotubal Junction of the Bovine (Bos taurus) vs. the Dromedary Camel (Camelus dromedarius): Histological and Histomorphometry Analysis
Authors: Abdoon Ahmed Sabry , Soliman Seham S. , Mohamed Ahmed N. 
Published: June 2023

Abstract
This study compares the histomorphology differences of cattle uterotubal junction (CUTJ) and dromedary camels uterotubal junction papilla (CUTJP). UTJ were dissected from eight cows and twelve camels with dominant follicles, and processed for H&E staining for morphology, histology, and histomorphometry examination. The results showed that the CUTJP existed only in camels and was completely absent in cattle. Histologically, CUTJ appears with a star-shaped lumen, and the mucosa lined by a simple columnar epithelium containing ciliated and non-ciliated cells, superficial (SG), and deep glands (D G) were abundant in the submucosa. CUTJP is a fibrous conical structure, it has a pale yellowish color and 0.5 ± 0.2 cm height and 0.3 ± 0.1 cm width. C UTJP, the lumen is wider, and the mucosa showed large multiple folds lined with ciliated and non-ciliated pseudostratified columnar epithelium. The submucosa showed no endometrial glands. Lumen area, lumen epithelial height, luminal epithelial density, the thickness of the muscular layer, number of folds, folds height, epithelial height, fold area, and epithelial perimeter were higher in CUTJP (P < 0.001) than CUTJ. While the total endometrial area and glandular epithelial density were lower in UTJP (P < 0.001) than in CUTJ. In conclusion, the epithelial lining, absence of glands, and the thick layer of tunica muscularis might indicate that camel CUTJP could play a mechanical role in selecting spermatozoa and assisting the hatching of blastocysts during their passage through it.
Using factor analysis to evaluate health related quality of life among patients with Kashin-Beck diseaase in Shaanxi provience, China
Authors: Zhao Yubo , Shi Zhi , Zhang Qingping , Qi Xin , Jia Peng , Yang Shujuan , Chen Ping , Song Yunlong , Liu Jie , Ding Qiongjie , Yang Zhengjun , Cui Chengbao , Wu Qian 
Published: June 2023

Abstract
Background:
Kashin-Beck disease (KBD) is one of the most prevalent endemic diseases in China, causing irreversible damage to the health of patients. Previous studies have mainly focused on the disease’s prevalence rate of KBD, which is not an effective indicator of patients’ health loss. Describing the distribution of health-related quality of life (HRQoL) from different areas and perspectives can better evaluate patients’ health and its influencing factors.
Methods:
Ten representative epidemic areas in Shaanxi Province were selected as the study areas in 2019, and a 36-item Short Form Health Survey (SF-36) was used to investigate the HRQoL of patients. Factor analysis classified indicators into two aspects: physical component summary (PCS) and mental component summary (MCS), evaluating the subjects’ HRQoL. Quantile Regression was used to explore influencing factors.
Results:
Patients with KBD in the northern areas of Shaanxi Province had lower MCS scores, including Huangling County (45.07), Baota District (45.22), and Yaozhou District (45.59). Patients from Yongshou County had the lowest PCS score, with a score of only 41.43. The main factors affecting HRQoL were patients’education level, marital status, and clinical grade. In PCS dimension, patients with an annual household income under 6,000 RMB had higher scores (P10, P25, P50, P75:β = 2.605, 3.308, 2.389, 3.478). In MCS dimension, male had higher scores than female, and the impact of patients who have never received education on their quality of life only had statistical significance in the interval with higher health scores (illiteracy P75, P90: β=-3.952, -3.288; primary level P50, P75: β=-2.274, -3.256).
Conclusions:
This study effectively evaluates the physical and mental health of KBD patients, emphasing the need for consideration of factors affecting patients’ physical activity and psychological well-being in future adjustments. Additionally, it provides important information for eliminating health inequalities and guiding further research.
WITHDRAWN: Seismic Analysis of RC framed Building Situated in High Risk Seismic Zone with Recyclable Scrap Tyre Mix for Base Isolation using Finite Element Modeling
Authors: Raj J. Cici Jennifer 
Published: June 2023

Abstract
Sustainable construction is a key component of the current trend. For civil engineers to master the talent of creating sustainable buildings, recyclable materials must be used. These recyclable waste items from industrial uses must be converted into practical building materials. A number of by-products that are particularly harmful to our environment include scrap tyres as a major ingredient. Used and worn-out automobile tyres could be used in construction as a basic isolation element. These discarded tyres will be utilized as bearings or crumbles for seismic shock absorbers. This paper emphasis the performance of a three-storey RC framed building situated in Nepal with and without scrap tyre crumb mix as base isolation material. The applications of SAP 2000 software package is completely applied for the investigation which is very unique. For instance, the dynamic properties of the building with respect to fixed base (without soil-structure interaction effect is studied) such as base shear, acceleration, displacement and frequencies of the building were studied. Subsequently, the dynamic properties pertaining to the implementation of soil-structure interaction analysis, with and without soil-tyre mix is computed and eventually compared with that of the building without soil-structure interaction criteria. The elegance of this paper is that the analysis has been conducted for five different combinations of tyre crumbs such as 0%, 10%, 20%, 30% and 50%. Furthermore, the investigation has been evaluated for two categories of importance factors such as 1 and 1.2. Moreover, the analysis has been enhanced by further study pertaining to soil conditions such as hard, medium and soft soil as per IS code conditions. From the study it is observed that, 30% tyre crumb combination has superior reduction in base shear, acceleration and frequencies and, increased displacement in all phases of the investigation.
LncRNA MAGI2-AS3 inhibited tumour progression by up-regulating STAM via interacting with miR-142-3p in clear cell renal cell carcinoma
Authors: Yang Riwei , Chen Zude , Ao Shan , Liang Leqi , Chen Zugen , Duan Xiaolu , Zeng Guohua , Deng Tuo 
Published: June 2023

Abstract
Background:
Non-coding RNA (ncRNA) is a class of RNAs that do not encode proteins but have multiple biological functions intracellular. They play an indispensable role in the occurrence and development of tumour. Therefore, understanding their molecular regulatory mechanisms in tumour cells are important for the treatment of tumour patients.
Methods:
The upstream ncRNAs of STAM were predicted by bioinformatic analysis, and the specific mechanism of lncRNA MAGI2-AS3 regulated miR-142-3p affecting STAM expression and participating in ccRCC cell proliferation, invasion, migration and apoptosis was detected by RT-qPCR, Western blotting, cellular functional experiments and luciferase reporter assay.
Results:
Overexpression of miR-142-3p or silencing of MAGI2-AS3 promoted the proliferation and migration of ccRCC cells, and inhibits cell apoptosis, while silencing of miR-142-3p or overexpression of MAGI2-AS3 had the opposite effect on ccRCC cells. Furthermore, we confirmed that MAGI2-AS3 acted as sponge and combined with miR-142-3p, blocked the inhibitory effect of miR-142-3p on the expression of STAM, thereby involved in ccRCC proliferation and metastasis. Furthermore, the prognostic model based on the MAGI2-AS3/miR-142-3p/STAM axis further emphasizes its prognostic value in ccRCC.
Conclusion:
MAGI2-AS3 competitively binding miR-142-3p to upregulate the STAM expression suppressing ccRCC proliferation and metastasis. MAGI2-AS3/miR-142-3p/STAM axis may serve as a promising ccRCC therapeutic target.
Prevalence, Characteristics, and Correlates of Avoidant/Restrictive Food Intake Disorder among Adult Respondents to the National Eating Disorders Association Online Screen: A Cross-Sectional Study
Authors: D'Adamo Laura , Smolar Lauren , Balantekin Katherine , Taylor C. Barr , Wilfley Denise , Fitzsimmons-Craft Ellen 
Published: June 2023

Abstract
Background
Avoidant/restrictive food intake disorder (ARFID) is a serious, albeit under-researched, feeding or eating disorder. This exploratory study utilized data from adult respondents to the National Eating Disorders Association (NEDA) online eating disorder screen to validate items assessing the presence of ARFID and examine the prevalence, clinical characteristics, and correlates of a positive ARFID screen compared to other probable eating disorder/risk categories.
Methods
Among 47,705 adult screen respondents between January 2022 and January 2023, the prevalence of a positive ARFID screen was calculated. Chi-square tests and t-tests compared demographics, eating disorder attitudes and behaviors, suicidal ideation, current eating disorder treatment status, and eating disorder treatment-seeking intentions between respondents with possible ARFID and other eating disorder diagnostic and risk categories. Clinical characteristics of respondents with possible ARFID were also examined.
Results
2,378 (5.0%) adult respondents screened positive for ARFID. Respondents with possible ARFID tended to be younger, male, and have lower household income, and were less likely to be White and more likely to be Hispanic/Latino than most other diagnostic/risk groups. They had lower weight/shape concerns and eating disorder behaviors than all other diagnoses but higher BMI than those with AN. 35% reported suicidal ideation, 47% reported intentions to seek treatment for an eating disorder, and 2% reported currently being in treatment. The most common clinical feature of ARFID was lack of interest in eating (80%), followed by food sensory avoidance (55%) and avoidance of food due to fear of aversive consequences (31%).
Conclusions
Findings from this study indicated that ARFID was prevalent among adult screen respondents and more common among individuals who were younger, male, non-White, Hispanic, and lower income relative to those with other eating disorders or at risk for an eating disorder. Individuals with possible ARFID frequently reported suicidal ideation and were rarely in treatment for an eating disorder. Further research is urgently needed to improve advances in the assessment and treatment of ARFID and improve access to care in order to prevent prolonged illness duration.
Liensinine and neferine exert neuroprotective effects via the autophagy pathway in transgenic Caenorhabditis elegans
Authors: Wu Mengchen , Gao Ye-Hui , Zhang Chen , Ma Bo-Tian , Lin Hong-Ru , Jiang Jin-Yun , Xue Meng-Fan , Li Shan , Wang Hong-bing 
Published: June 2023

Abstract
Liensinine and neferine are the main bisbenzylisoquinoline alkaloids obtained from the seeds of Nelumbo nucifera, which commonly used as edible food and traditional medicine in Asia. It was reported that liensinine and neferine could inhibit the activities of acetylcholinesterase and cross the blood-brain barriers, maybe promising candidates to treat Alzheimer’s disease. Here we employed the APPswe transfected SH-SY5Y neural cells and transgenic Caenorhabditis elegans to investigate the neuroprotective effects and underlying mechanism of liensinine and neferine. Finally, we found that liensinine and neferine could significantly improve the viability and reduce ROS levels in APPswe cells, inhibit β-amyloid and tau-induced toxicity, and enhance stress resistance in nematodes. Moreover, liensinine and neferine had obviously neuroprotective effects by assaying chemotaxis, 5-hydroxytryptamine sensitivity and the integrity of injured neurons in nematodes. Preliminary mechanism studies revealed that liensinine and neferine could upregulate the expression of autophagy related genes (lgg-1, unc-51, pha-4, atg-9 and ced-9) and reduce the accumulation of β-amyloid induced autophagosomes, which suggested autophagy pathway played a key role in neuroprotective effects of these two alkaloids. Altogether, our findings provided a certain working foundation for the use of liensinine and neferine to treat Alzheimer’s disease based on neuroprotective effects.
The Influence of Interactions Between Two High-Rise Buildings on the Wind-Induced Moment
Authors: Yadav Himanshu , Roy Amrit Kumar , Kumar Anoop 
Published: June 2023

Abstract
The purpose of the study was to explore the interference effects on the wind-induced moment caused by two nearby high-rise structures. In order to use computational fluid dynamics (CFD), a stiff full-scale model of the buildings was created. Numerous wind incidence angles and two alternative model cross sections were used in the investigation. Additionally, it was looked at how building heights and aspect ratios affected interference effects. The findings showed that when there was a close proximity between the structures, the interference effects on the wind-induced moment were most noticeable. The study also showed that interference effects were more evident for structures with greater aspect ratios. The degree of interference effects was also greatly influenced by the angle of wind incidence, with perpendicular wind directions having the greatest effects. These results underline how crucial it is to carefully examine the positioning and orientation of high-rise structures when making wind-induced moment designs. To ensure structural stability and reduce potential negative impacts from interference, designers and engineers should consider the proximity of neighboring structures, the aspect ratios of the buildings, and the angle at which the wind strikes the buildings. In wind-prone places, high-rise buildings' safety and performance can be greatly improved by include such factors in the design process.
Clinical profile and factors affecting prognosis in leptospirosis: A retrospective study from a tertiary care center in rural Karnataka
Authors: C Manasa Dixit , K Prabhakar , P Praveen 
Published: June 2023

Abstract
Purpose
To optimize the management of leptospirosis, it is crucial to have a comprehensive understanding of the disease characteristics, ICU needs, and mortality rates associated with the disease.
Methods
The retrospective observational study included patients between 1st April 2021 and 31st March 2022 in the Department of general medicine, at R.L Jalappa Hospital, India. The study collected clinical and laboratory parameters, as well as the Sequential Organ Failure Assessment (SOFA) score, within the first 24 hours of admission. The outcome at discharge was considered, and a prediction model was constructed using regression analysis.
Results
The study included 61 patients with a mean age of 36.79 years. Patients with abnormal respiratory findings during clinical evaluation were more likely to require ICU care. A significantly high mortality rate was observed among patients who needed ICU care. Furthermore, a significant difference in the SOFA score, calculated within the first 24 hours of hospital admission, was observed between deceased and recovered patients. The predictors of mortality, as evaluated by regression analysis, included the SOFA score, abnormal respiratory findings in the clinical examination, and the Coagulation component of the SOFA score.
Conclusion
Abnormal respiratory findings, altered sensorium, total white blood cell (WBC) counts, and the coagulation component of the score were identified as significant predictors of ICU requirement. In leptospirosis, the SOFA score, particularly the coagulation component, and the abnormal respiratory system findings were found to be predictors of outcome. These factors can be easily assessed even in resource-poor settings to prognosticate patients with leptospirosis.
Yoga therapy versus usual care on health-related quality of life in adults with chronic illness: A systematic review
Authors: Nirwan Mohit , Saha Mantu 
Published: June 2023

Abstract
Health-related Quality of Life (HRQoL) is often found to be poor in patients with systemic diseases like Diabetes Mellitus (DM), Chronic Obstructive Pulmonary Disease (COPD), Myocardial Infarction (MI), and cancer. Yoga intervention in clinical research seems to be effective to explore its’ beneficial effects to improve patient’s quality of life suffering from chronic illnesses. It was tried to examine and summarize available evidence through a systematic review that yoga exerts positive effects on patients’ QoL. RCTs were included that explored yoga’s effect on QoL for patients suffering from chronic illness. RCTs with at least 8 weeks of yoga intervention were included. Electronic databases were systematically searched to filter RCTs as per the pre-defined inclusion criteria. RoB2 was used to assess the risk of bias in the selected studies. Published validated QoL questionnaire was the eligible and primary outcome. Among the 1830 studies that were identified initially, 12 studies met all the inclusion criteria. Four studies informed a significant improvement in QoL scores in patients in the yoga arm compared to the usual care group. There was heterogeneity among the included studies and most studies raised ‘some concerns’ about the risk of bias. There is not enough evidence to prove that yoga does improve QoL in patients which is statistically and clinically relevant. Low adherence and compliance to the yoga intervention in the patients and the absence of high-quality RCTs may be the reason. All the studies concluded that yoga is beneficial, safe, and feasible for patients.
Environmental recovery of As Pontes mine pit lake
Authors: Rivas Francisco , Samper Javier , Montenegro Luis 
Published: June 2023

One of the most common solutions for more than 50 years for the recovery of mine holes generated during mining activities is their transformation into lakes. This paper presents the activities carried out from the closure of the As Pontes mine to the total filling of the mining lake. The environmental solution adopted for the recovery of the mining hole and its transformation into a mining lake is described, as well as the methodology followed for its filling, defining the water sources used, its volume and its chemical quality. Perfect mix and stratified lake models were performed to simulate the final chemical quality of the lake. The details of the studies carried out on waves on the shores of the lake and the stability of the slopes of the mine are also presented. The hydraulic works carried out to reintegrate into the lake the watercourses that were diverted during the mining exploitation are also indicated. Water chemical data of the As Pontes lake collected during and after the filling of the lake show the presence of two well-differentiated zones separated by a chemocline. The uppermost layer has a slightly acid pH and oxic conditions, while the deeper layer has very low pH values and anoxic conditions. The methodology used was successful and the forecasts made are in line with the results obtained both in relation to the filling time of the lake and the quality of the overflow waters, which comply with all the established limits.
MATURIDADE DA DISSEMINAÇÃO DO CONHECIMENTO DA PROPRIEDADE INTELECTUAL EM RELAÇÃO AOS PEQUENOS EMPREENDEDORES
Authors: Alves Gomes Rolim Amanda , Luís Diego Sousa e Silva  , Francisco Fábio Cavalcante Barros  , Joelia Marques de Carvalho  
Published: June 2023

O estudo desenvolvido neste artigo, tem como objetivo avaliar a maturidade do conhecimento sobre o uso da propriedade intelectual por parte dos pequenos empreendedores e analisar a disseminação deste uso da PI em um contexto geral. Ademais, serão apresentadas ações que visem ampliar os conhecimentos e aplicações da propriedade intelectual para os pequenos empreendedores, anlisando todo um contexto de empreendedorismo, principalmente no quesito por oportunidades e por necessidade. É sabido que há uma grande parcela da sociedade, em específico o alvo da pesquisa, no caso os pequenos empreendedores, que não conhecem a importância dos direitos e deveres relativos à propriedade intelectual, além do seu benefício em desenvolvimento de novos produtos tecnológicos, bem como a proteção jurídica dos ativos intangíveis, como marcas, patentes, desenhos industriais, indicações geográficas, direitos autorais. Foram utilizadas na produção do artigo, a metodologia qualitativa e quantitativa, através da obtenção de dados oriundos de pesquisas exploratórias. Os dados coletados foram analizados por meio das pesquisas exploratórias por meio de artigos e dados de órgãos públicos, e descritos ao longo da produção. Ademais, será disposto como esse nível de conhecimento e eventuais usos do sistema de PI estão sendo realizados, bem como vem impactanto a utilização desses conhecimentos nas atividades desses empreendedores, pois a inovação quando adequadamente estimulada contribui para o processo de geração de riquezas e consequentemente uma melhor qualidade de vida da população.
Recent Applications of Deconvolution Microscopy in Medicine
Authors: Katoh Kazuo 
Published: June 2023

Abstract:
Deconvolution microscopy is a computational image-processing technique used in conjunction with fluorescence microscopy to increase the resolution and contrast of three-dimensional images. Fluorescence microscopy is a widely used technique in biology and medicine that involves labeling specific molecules or structures within a sample with fluorescent dyes and then electronically photographing the sample through a microscope. However, the resolution of conventional fluorescence microscopy is limited by diffraction within the microscope’s optical path, which causes blurring of the image and reduces the ability to resolve structures in close proximity with one another. Deconvolution microscopy overcomes this limitation by means of computer-based image processing whereby mathematical algorithms are used to eliminate the blurring caused by the microscope’s optics and thus obtain a higher-resolution image that reveals the fine details of the sample with greater accuracy. Deconvolution microscopy, which can be applied to a range of image acquisition modalities, including widefield, confocal, and super-resolution microscopy, has become an essential tool for studying the structure and function of biological systems at the cellular and molecular levels. In this perspective, the latest deconvolution techniques have been introduced and image-processing methods for medical purposes have been presented.
Gestión, intervenciones y sujetos patrimoniales en la recuperación del Centro Histórico del Rímac (1991-2018)
Authors: Palpán López Saly 
Published: June 2023

En el interés de apuntar hacia la intervención integral de los centros históricos, el tema de la gestión se plantea como un sistema que articula todas las actuaciones sobre los centros históricos en sus distintas dimensiones tangibles e intangibles. De esta manera, la gestión como objeto de estudio permite un acercamiento a las dinámicas de rehabilitación multidimensional, en lo referido a las temáticas emergentes de estudio urbano, multiescalar, en la articulación de las diferentes escalas de planificación y gobierno; y multiactoral, en la implicancia en la toma de decisiones de diversos sujetos y sus intereses sobre el territorio. El objetivo del artículo es contribuir al conocimiento sobre el área correspondiente al distrito del Rímac en el Centro Histórico de Lima que en los últimos años ha sido reconocida local e internacionalmente como el Centro Histórico del Rímac. Desde un enfoque histórico, se plantea el reconocimiento del sistema de gestión en la recuperación del Centro Histórico del Rímac generado por los sujetos patrimoniales involucrados en dicho proceso en el periodo 1991-2018. Asimismo, se identificaron valores y discursos patrimoniales desde la tematización de los procesos de gestión y la participación de actores sociales específicos en dichos procesos.