bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pharmacoinvasive Therapy in Treating Acute STEMI Patients in Covid-19 Era
Authors: Islam AHM Waliul , Reza AQM , Talukder Shahabuddin , Munwar Shams , Ali Atahar , Ahmed Tamzeed , Rahman Kazi Atiqur , Bhuiyan Azfar H , Karim Aparajita , Bala Poppy , Islam Nighat , Reza Abeda Tasnim , Hossain Tanbir A , Haque Md Zahidul 
Published: April 2023

Background: Treating acute ST segment elevated myocardial infarction (STEMI) patients by primary PCI (pPCI) has dramatically fallen globally in covid era as there is chances of potential threat of spreading COVID among the non-COVID patients. Thereby, thrombolysis of acute STEMI patient in grey zone till COVID RT PCR report to come, was the mode of treatment of acute myocardial infarction patient in our hospital. We have carried out this prospective observational study to see the outcomes of thrombolysis and subsequent intervention.
Methods: STEMI patient who presented to our emergency department with chest pain and ECG and hs-Troponin-I evidenced acute STEMI, were enrolled in the study. Total 139 patients enrolled (Male:120, Female :54); average age for Male: 54 yrs., female was: 56yrs. All patients were admitted in the grey zone of CCU where thrombolysis was done. COVID-19 patients were excluded from intervention and managed conservatively. Covid Negative patients were kept transferred to CCU green zone. On average 2.1 days after Fibrinolysis, elective PCI carried out. Data analysis from 48 patients who underwent pharmacoinvasive therapy was done.
Results: Among the study population, Covid-19 positive was in 11 (7.9%) patients and Covid-19 was negative in 128 (92.1%) patients. Primary PCI was performed in 7 (5.03%) patients. Rest of the patients were managed by Pharmacoinvasive therapy. Thrombolysis by Tenecteplase (TNK) was done in 89 (64%) patients, and by Streptokinase in 25 (17.9%) patients, 18 (12.9%) patients did not receive any thrombolysis due to late presentation. Chest pain to needle time was 7.2 ±12.7hrs., thrombolysis to balloon time was 117.5 ±314.8hrs. More than 50% stenosis resolution observed in 20 (41.6%) patients, chest pain resolution within one hour of thrombolysis observed in 21 (43.8%) patients. Ten (20.8%) patients developed. Door to needle time was 30 mins. Total, 88 stents were deployed in 83 territories. CABG was recommended for 7 (5.03%) patients. Stented territory was LAD 37 (45.7%) and RCA 32 (39.5%) and LCX 12 (14.8%).
Conclusion: In the era of COVID-19, in this prospective cohort study, on acute STEMI patient management, we found that Pharmacoinvasive therapy, reduced patients’ symptoms and ST resolution occurred partially.
Cardiovasc j 2023; 15(2): 136-143
Atuação da enfermagem na prevenção de infecções urinárias associadas à sondagem vesical de demora na unidade de terapia intensiva adulto
Authors: Machado Helenira Macêdo Barros , Ramalho Carla Alves , Nunes Talia Sousa 
Published: April 2023

O presente estudo tem como objetivo identificar a importância da assistência de enfermagem nas infecções urinárias associadas ao cateter vesical de demora na UTI-A. Trata-se de uma pesquisa do tipo descritiva, com fonte bibliográfica integrativa e abordagem qualitativa. A busca de dados se deu através de dados secundários: revisão bibliográfica integrativa e pesquisas documentais. O processamento ocorreu pela utilização de informações disponibilizadas através de busca de artigos científicos publicados no período de 2012 a 2021 existentes nas bases de dados Lilacs (Literatura Latino-Americana e do Caribe em Ciências da Saúde), SciELO (Scientific Eletronic Library Online), BVS (Biblioteca Virtual em Saúde) e Google Acadêmico. Selecionamos 15 artigos para o levantamento da amostra bibliográfica, levando em consideração aqueles com maior importância para o objeto de estudo. Assim fica evidente a importância do enfermeiro na prevenção das ITU-AC, que utilizando de métodos simples como higienização das mãos e atualizações de seus conhecimentos podem influenciar na prevenção, monitoramento e complicações das ITU-AC.
Respostas biométricas de plantas de sorgo e feijão-mungo expostas aos estresses isolados e combinados de salinidade e alumínio
Authors: Silva Maria Eduarda Cabral da , Melo Ana Raquel Pereira de , Souza Cleriston Correia da Silva , Pereira Neto José Alves , Costa Neto Vicente Paulo da , Lima Victor Breno Campelo , Bonifacio Aurenivia 
Published: April 2023

Os estresses abióticos induzem alterações de crescimento e perda de produtividade nas espécies vegetais. O presente estudo objetivou avaliar as respostas de plantas de feijão-mungo e sorgo submetidas ao estresse salino (0, 50 e 150 mM de NaCl) e por alumínio (0 e 1,0 µM de Al) de forma isolada ou em combinação com base na mensuração da taxa de crescimento absoluto, altura das plantas, massa fresca da parte aérea e das raízes e o comprimento das raízes. Observou-se que as plantas de sorgo apresentaram valores superiores de taxa de crescimento absoluto e da altura das plantas em relação ao feijão-mungo, sendo os demais parâmetros similares entre as duas culturas. A salinidade e estresse por alumínio induziram efeitos negativos quando aplicados de forma isolada ou combinada em todas as variáveis analisadas para as duas culturas testadas. A combinação de 150 mM de NaCl e 1,0 µM de Al não afetou a altura das plantas, massa fresca e comprimento das raízes de plantas de sorgo em relação ao observado nas plantas estressadas apenas com 150 mM de NaCl. O comprimento das raízes de plantas de feijão-mungo estressadas com 1,0 µM de Al foi estatisticamente similar ao observado nas plantas expostas simultaneamente a 50 mM de NaCl e 1,0 µM de Al. As plantas de sorgo apresentaram melhores respostas aos estresses salino e por alumínio em relação às plantas de feijão-mungo, possivelmente devido ao metabolismo C4 presente nestas plantas que permite maior captação de CO2 e acúmulo de biomassa.
O correlato anímico da mimese poética nos escritos sobre a alma e a imaginação de Aristóteles
Authors: Nuesch Enrique 
Published: April 2023

Este texto trata de demonstrar que o conceito de mimese presente na Poética de
Aristóteles pode ser esclarecido pela relação com outros tratados do autor, nos quais se explora a imaginação enquanto potência da alma. Para isso, destacamos passagens importantes da poética, a partir das quais se tecem as relações com os demais textos. Conclui-se que uma investigação mais aprofundada sobre a imaginação pode trazer luz ao conceito de mimese da Poética, que não recebe definição naquele tratado.
El cine como herramienta didáctica para la inclusión del elemento cultural en la clase de inglés como lengua extranjera
Authors: Álvarez-Gil Francisco J. , Alonso-Almeida Francisco 
Published: April 2023

En el presente estudio se realiza una propuesta didáctica para la introducción del componente cultural en la enseñanza del inglés como lengua extranjera utilizando el cine como herramienta didáctica. El uso de fragmentos de diferentes películas tendrá como resultado una clase más atractiva para los alumnos con una visión novedosa y diferente y, al mismo tiempo, promovemos el desarrollo de la capacidad investigadora del alumnado desde la etapa de educación obligatoria. En este estudio se realiza una propuesta metodológica donde, basándonos en el marco teórico presentado, se ofrecen algunos ejemplos de actividades basadas en el empleo del cine como principal herramienta de enseñanza.
Abnormal left atrial compliance is associated with a history of life-threatening arrhythmia in corrected Tetralogy of Fallot
Authors: Vautier Mathilde , Mulet Benoit , Macquaire Clémence , Cousergue Cynthia , André Camille-Océane , Maragnes Pascale , Ollitrault Pierre , Labombarda Fabien 
Published: April 2023

ObjectivesThe objectives of this study were to examine left atrial (LA) function and compliance using two-dimensional (2D) strain analysis in adult patients with corrected Tetralogy of Fallot (c-ToF) and to investigate the relationships between LA function and patient characteristics, especially history of life-threatening arrhythmia (h-LTA).MethodsFifty-one c-ToF patients (34 males; age, 39 ± 15 years; h-LTA, n = 13) were included in this retrospective monocenter study. In addition to a 2D standard echocardiography examination, 2D strain analysis was performed to assess left ventricular (LV) and LA functions, including peak-positive LA strain (LAS—reservoir function) and LA compliance [defined as the ratio LAS/(E/Ea)].ResultsPatients with h-LTA were older and exhibited a longer QRS duration. LV ejection fraction, LAS and LA compliance were significantly lower in the group of patients with h-LTA. Indexed LA and RA volumes, RV end-diastolic area was significantly higher and RV fractional area change significantly lower in the h-LTA group. LA compliance was the best echocardiographic predictor for h-LTA (AUC: 0.839; p &lt; 0.001). Moderate inverted correlations were found between LA compliance and age and QRS duration. Among the echocardiographic parameters, LA compliance was moderately inversely correlated with RV end-diastolic area (r = −0.40, p = 0.01).ConclusionWe documented abnormal LAS and LA compliance values in adult c-ToF patients. Further study is needed to determine how best to incorporate LA strain, particularly LA compliance, into multiparametric predictive models for LTA in c-ToF patients.
Peritumoral adipose tissue promotes lipolysis and white adipocytes browning by paracrine action
Authors: Pagnotta Priscila , Gantov Mariana , Fletcher Sabrina , Lombardi Antonella , Crosbie María Lujan , Santiso Natalia , Ursino Anabela , Frascarolli Celeste , Amato Alicia , Dreszman Rubén , Calvo Juan Carlos , Toneatto Judith 
Published: April 2023

BackgroundStromal adipocytes and tumor breast epithelial cells undergo a mutual metabolic adaptation within tumor microenvironment. Therefore, browning and lipolysis occur in cancer associated adipocytes (CAA). However, the paracrine effects of CAA on lipid metabolism and microenvironment remodeling remain poorly understood.MethodsTo analyze these changes, we evaluated the effects of factors in conditioned media (CM) derived from explants of human breast adipose tissue from tumor (hATT) or normal (hATN) on morphology, degree of browning, the levels of adiposity, maturity, and lipolytic-related markers in 3T3-L1 white adipocytes by Western blot, indirect immunofluorescence and lipolytic assay. We analyzed subcellular localization of UCP1, perilipin 1 (Plin1), HSL and ATGL in adipocytes incubated with different CM by indirect immunofluorescence. Additionally, we evaluated changes in adipocyte intracellular signal pathways.ResultsWe found that adipocytes incubated with hATT-CM displayed characteristics that morphologically resembled beige/brown adipocytes with smaller cell size and higher number of small and micro lipid droplets (LDs), with less triglyceride content. Both, hATT-CM and hATN-CM, increased Pref-1, C/EBPβ LIP/LAP ratio, PPARγ, and caveolin 1 expression in white adipocytes. UCP1, PGC1α and TOMM20 increased only in adipocytes that were treated with hATT-CM. Also, hATT-CM increased the levels of Plin1 and HSL, while decreased ATGL. hATT-CM modified the subcellular localization of the lipolytic markers, favoring their relative content around micro-LDs and induced Plin1 segregation. Furthermore, the levels of p-HSL, p-ERK and p-AKT increased in white adipocytes after incubation with hATT-CM.ConclusionsIn summary, these findings allow us to conclude that adipocytes attached to the tumor could induce white adipocyte browning and increase lipolysis as a means for endocrine/paracrine signaling. Thus, adipocytes from the tumor microenvironment exhibit an activated phenotype that could have been induced not only by secreted soluble factors from tumor cells but also by paracrine action from other adipocytes present in this microenvironment, suggesting a “domino effect”.
New insights into the genetic structure of the outbreak-prone bamboo grasshoppers
Authors: Song Zimeng , Ze Sangzi , Liu Chunxiang , Chen Bing 
Published: April 2023

IntroductionThe genetic structure of species is shaped by natural (e.g., terrain, climate) and non-natural (e.g., human activities) factors. Geographical isolation and natural barriers are important causes of genetic structure formation of species. Here, we explored this issue in bamboo grasshopper, Ceracris kiangsu, which is an important pest that feeds on bamboo in East and Southeastern Asia.MethodsBased on 186 newly sequenced and 286 previously sequenced mitochondrial COI fragments, and 8 nuclear microsatellite loci, we examined the genetic diversity and population genetic structure of C. kiangsu.ResultsThe degree of genetic differentiation among populations was also high, and Mantel test showed that it was significantly correlated with geographical distance. Principal coordinate analysis and STRUCTURE results revealed two genetically different groups, a South China (S-China) Group and a Southeast Asia (SE-Asia) Group. Climate variables partly explained the population genetic structure. The demographic history and ABC showed that the S-China Group experienced population expansion, whereas the SE-Asia Group was consistently stable.DiscussionOur study demonstrates an obvious population structure maintained in this migratory insect and reveals the potential effect of past climatic change, geographical isolation, and ecological factors on the evolution of their genetic structure.
Exploring the feasibility of technological transfers of two by-catch reduction devices in the crustacean bottom trawling of the central Mediterranean
Authors: Geraci Michele Luca , Sardo Giacomo , Scannella Danilo , Falsone Fabio , Di Maio Federico , Gancitano Vita , Fiorentino Fabio , Chirco Pierangela , Massi Daniela , Vitale Sergio 
Published: April 2023

IntroductionMost Mediterranean fish stocks are overexploited owing to high fishing efforts and poor exploitation patterns. Demersal trawl fisheries are considered the most impactful fishery type because of the high quantities of unwanted catch that is then routinely discarded at sea.MethodsIn the present study, two types of by-catch reduction devices (BRDs), that is a sorting grid (Grid-T45 40 mm) and a T90 50 mm codend, were compared to a typical commercial bottom trawl net (control) in terms of size structures and catch per unit effort to assess the effect of gear modification on the selectivity of crustacean fisheries in the central Mediterranean Sea. In particular, three randomly selected trawlers were involved in a paired hauls experiment fishing at the same time in the same fishing ground. Each trawler carried out four hauls per day during a 3-day campaign for a total of 36 hauls. The target species of the fishery is Parapenaeus longirostris (herein DPS), and the main commercial by-catch is Merluccius merluccius (herein HKE).ResultsThe results showed that the landing per unit effort (LPUE) of DPS was higher for Grid-T45 40 mm net, although it did not differ significantly from that of the control net. Conversely, the discard per unit effort (DPUE) of the control net was significantly higher than of both BRD configurations. For HKE, a slightly higher LPUE was recorded using the T90 50 mm codend compared to that of the control, but this result was not statistically significant. The lowest DPUE was found for the T90 50 mm codend, with significant differences compared to that of the control and Grid-T45 40 mm net. The catch comparison of the size structures analysed through generalised linear mixed models highlighted that the Grid-T45 40 mm net was more effective in catching adult DPS, whereas the T90 50 mm codend was more selective for adult HKE.DiscussionIn conclusion, although further studies should be carried out in future to test the performance of the BRDs in different areas and seasons, the investigated gear seems to be promising for reducing the catch of undersized individuals and contributing to mitigating the current overfishing of DPS and HKE.
Data quality control considerations in multivariate environmental monitoring: experience of the French coastal network SOMLIT
Authors: Breton Elsa , Savoye Nicolas , Rimmelin-Maury Peggy , Sautour Benoit , Goberville Eric , Lheureux Arnaud , Cariou Thierry , Ferreira Sophie , Agogué Hélène , Alliouane Samir , Aubert Fabien , Aubin Sébastien , Berthebaud Eric , Blayac Hadrien , Blondel Lucie , Boulart Cédric , Bozec Yann , Bureau Sarah , Caillo Arnaud , Cauvin Arnaud , Cazes Jean-Baptiste , Chasselin Léo , Claquin Pascal , Conan Pascal , Cordier Marie-Ange , Costes Laurence , Crec’hriou Romain , Crispi Olivier , Crouvoisier Muriel , David Valérie , Del Amo Yolanda , De Lary Hortense , Delebecq Gaspard , Devesa Jeremy , Domeau Aurélien , Durozier Maria , Emery Claire , Feunteun Eric , Fauchot Juliette , Gentilhomme Valérie , Geslin Sandrine , Giraud Mélanie , Grangeré Karine , Grégori Gerald , Grossteffan Emilie , Gueux Aurore , Guillaudeau Julien , Guillou Gael , Harrewyn Manon , Jolly Orianne , Jude-Lemeilleur Florence , Labatut Paul , Labourdette Nathalie , Lachaussée Nicolas , Lafont Michel , Lagadec Veronique , Lambert Christophe , Lamoureux Jezebel , Lanceleur Laurent , Lebreton Benoit , Lecuyer Eric , Lemeille David , Leredde Yann , Leroux Cédric , Leynaert Aude , L’Helguen Stéphane , Liénart Camilla , Macé Eric , Maria Eric , Marie Barbara , Marie Dominique , Mas Sébastien , Mendes Fabrice , Mornet Line , Mostajir Behzad , Mousseau Laure , Nowaczyk Antoine , Nunige Sandra , Parra René , Paulin Thomas , Pecqueur David , Petit Franck , Pineau Philippe , Raimbault Patrick , Rigaut-Jalabert Fabienne , Salmeron Christophe , Salter Ian , Sauriau Pierre-Guy , Seuront Laurent , Sultan Emmanuelle , Valdès Rémi , Vantrepotte Vincent , Vidussi Francesca , Voron Florian , Vuillemin Renaud , Zudaire Laurent. , Garcia Nicole 
Published: April 2023

IntroductionWhile crucial to ensuring the production of accurate and high-quality data—and to avoid erroneous conclusions—data quality control (QC) in environmental monitoring datasets is still poorly documented.MethodsWith a focus on annual inter-laboratory comparison (ILC) exercises performed in the context of the French coastal monitoring SOMLIT network, we share here a pragmatic approach to QC, which allows the calculation of systematic and random errors, measurement uncertainty, and individual performance. After an overview of the different QC actions applied to fulfill requirements for quality and competence, we report equipment, accommodation, design of the ILC exercises, and statistical methodology specially adapted to small environmental networks (&lt;20 laboratories) and multivariate datasets. Finally, the expanded uncertainty of measurement for 20 environmental variables routinely measured by SOMLIT from discrete sampling—including Essential Ocean Variables—is provided.Results, Discussion, ConclusionThe examination of the temporal variations (2001–2021) in the repeatability, reproducibility, and trueness of the SOMLIT network over time confirms the essential role of ILC exercises as a tool for the continuous improvement of data quality in environmental monitoring datasets.
Ten-year trends of the clinicopathological characteristics, surgical treatments and survival outcomes of operable lung cancer patients in monocenter: a retrospective cohort study
Authors: Zhao Dechang , He Xiaotian , Zhang Rusi , Huang Zirui , Wen Yingsheng , Zhang Xuewen , Wang Gongming , Guo Guangran , Chen Lianjuan , Zhang Lanjun 
Published: April 2023

BackgroundLung cancer is one of the cancers with the highest morbidity and mortality. During the last decade, the trends of clinical characteristics, surgical treatments and survival of lung cancer patients in China have remained unclear.MethodsAll lung cancer patients operated on from 2011 to 2020 were identified in a prospectively maintained database of Sun Yat-sen University Cancer Center.ResultsA total of 7,800 lung cancer patients were included in this study. Within the past 10 years, the average age at diagnosis of the patients remained stable, the proportion of asymptomatic, female and nonsmoking patients increased, and the average tumor size decreased from 3.766 to 2.300 cm. In addition, the proportion of early stage and adenocarcinoma increased, while that of squamous cell carcinoma decreased. Among the patients, the proportion of patients having video-assisted thoracic surgery increased. More than 80% of the patients underwent lobectomy and systematic nodal dissection over the 10 years. Additionally, both the average postoperative length of stay and 1-, 3-, and 6-month postoperative mortality decreased. Moreover, the 1-, 3-, and 5-year overall survival (OS) rates of all the operable patients increased from 89.8, 73.9, and 63.8% to 99.6, 90.7, and 80.8%, respectively. The 5-year OS rates of the patients with stage I, II, and III lung cancer were 87.6, 79.9, and 59.9%, respectively, which were higher than those in other published data.ConclusionThere were significant changes in the clinicopathological characteristics, surgical treatments and survival outcomes of the patients with operable lung cancer from 2011 to 2020.
18F-FDG primary tumor uptake to improve N status prediction in cT1 non-metastatic non-small cell lung cancer: development and validation of a positron emission tomography model
Authors: Morland David , Chiappetta Marco , Falcoz Pierre-Emmanuel , Chenard Marie-Pierre , Annunziata Salvatore , Boldrini Luca , Lococo Filippo , Imperiale Alessio 
Published: April 2023

Purpose:Occult lymph node involvement is a major issue in the management of non-small cell lung carcinoma (NSCLC), with an estimated prevalence of approximately 2.9–21.6% in 18F-FDG PET/CT series. The aim of the study is to construct a PET model to improve lymph node assessment.Methods:Patients with a non-metastatic cT1 NSCLC were retrospectively included from two centers, one used to constitute the training set, the other for the validation set. The best multivariate model based on Akaike’s information criterion was selected, considering age, sex, visual assessment of lymph node (cN0 status), lymph node SUVmax, primary tumor location, tumor size, and tumoral SUVmax (T_SUVmax). A threshold minimizing false pN0 prediction was chosen. This model was then applied to the validation set.Results:In total, 162 patients were included (training set: 44, validation set: 118). A model combining cN0 status and T_SUVmax was selected (AUC 0.907, specificity at threshold: 88.2%). In the validation cohort, this model resulted in an AUC of 0.832 and a specificity of 92.3% versus 65.4% for visual interpretation alone (p = 0.02). A total of two false N0 predictions were noted (1 pN1 and 1 pN2).Conclusion:Primary tumor SUVmax improves N status prediction and could allow a better selection of patients who are candidates for minimally invasive approaches.