bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between BNT162b2 vaccination and health-related quality of life up to 18 months post-SARS-CoV-2 infection in Israel
Authors: Kuodi Paul , Gorelik Yanay , Zayyad Hiba , Wertheim Ofir , Beiruti Wiegler Karine , Abu Jabal Kamal , Dror Amiel A. , Elsinga Jelte , Nazzal Saleh , Glikman Daniel , Edelstein Michael 
Published: September 2023

AbstractWe determined whether COVID-19 vaccination was associated with Quality of Life (QoL) changes among individuals previously infected with SARS-CoV-2 in Israel. Using a validated questionnaire, we collected information about socio-demographics, SARS-CoV-2 infection, COVID-19 vaccination and QoL (using the EQ-5D-5L tool) 3–18 months post-infection among adults tested for SARS-CoV-2 by polymerase chain reaction in Northern Israel between March 2020–June 2022. We compared post-COVID QoL between those vaccinated against COVID-19 at the time of infection and those not, using an adjusted linear regression model, stratified by time elapsed since infection. Of 951 participants, mean EQ-5D Utility Index (EQ-5D UI) was 0.82 (SD = 0.26) and 0.83 (SD = 0.25) among the 227 double and 250 triple vaccinated respectively, compared to 0.76 (SD = 0.33) among those who received 0 dose (n = 243). The size of the effect of vaccination was small (Cohen’s d = 0.2). In the adjusted model, previously infected individuals vaccinated with two or more doses reported a QoL score post- infection 0.05 points higher (CI = 0.01–0.10, p = 0.02) compared with those unvaccinated when infected. No association between vaccination and QoL was detected beyond 12 months post-infection. Vaccination with two or more doses of COVID19 vaccine, or at least the BNT162b2 vaccine, may modestly mitigate QoL losses associated with post-acute COVID-19 symptoms, at least in the first 12 months post-infection.
A mobile car monitoring system as a supplementary tool for air quality monitoring in urban and rural environments: the case study from Poland
Authors: Maslouski Mikita , Jarosz-Krzemińska Elżbieta , Jagoda Paweł , Adamiec Ewa 
Published: September 2023

AbstractLiving in healthy environment should be regarded as a primary human right and not a privilege rendered to chosen ones. For that reason, a national air monitoring grid should be as extensive as possible. Unfortunately, small towns and villages, which are also exposed to air pollution episodes are not commonly covered by monitoring grid. Fixed air monitoring systems have their limitations, which can be overcome by e.g., properly validated, reliable but cheaper mobile monitoring systems. The aim of this study was to assess the use of a car mobile PM10 monitoring system to study ambient air quality in rural communities surrounding Kraków, not covered by fixed monitoring grid. A monitoring dataset was collected during 6 winter car campaigns conducted between December 2021 and March 2022. Except for providing multiple monitoring data, the main goal pertain to methodological aspect of the mobile system, including its validation, indicating its advantages, limitations as well as providing recommendations for the future mobile studies. Our car mobile monitoring system was useful in identifying a local hot-spots with good spatial and temporal resolution, thus giving the local government decision-making tool for taking appropriate action in places not included in national monitoring grid.
Acute kidney injury in children: incidence, awareness and outcome—a retrospective cohort study
Authors: Chisavu Flavia , Gafencu Mihai , Stroescu Ramona , Motofelea Alexandru , Chisavu Lazar , Schiller Adalbert 
Published: September 2023

AbstractThe primary objective was to determine the epidemiologic influence of AKI awareness among physicians in a mixt paediatric population, including neonates. This single-centre, multiyear, observational retrospective study included all admitted patients between first of July 2014 and 31 December 2021. AKI was identified in 2194 patients out of the 128,036 hospital admissions with 129,936 serum creatinine measurements. Matching comparisons were used between AKI aware and AKI non-aware patients. The overall incidence of AKI was 1.65%. Stage 1 was identified in 24.24% of the AKI cases, stage 2 in 31.03% and stage 3 in 44.71%. The most prevalent cause of AKI was represented by prerenal AKI in 85.64% of the cases, followed by 12.16% renal causes respectively 2.18% postrenal causes. Exposure to sepsis, critical illness, hypovolemic shock and mechanical ventilation increased mortality by 2.09, 4.69, 4.64- and 4.93-times (p = 0.001). Cancer and heart failure increased mortality by 4.22 (p < 0.001) respectively 2.17 times (p = 0.001). The presence of AKI increased mortality by 79.11 times while only half of the AKI associated deaths were recognized by physicians. AKI increased hospitalization more than 4 times the average stay. AKI awareness was dependent of lower age and severity. Also, awareness increased mortality and prolonged hospitalization. 1 in 3 neonates and 1 in 4 children were AKI aware. The physician’s awareness of AKI diagnosis is in general low due to lack of appliance of current guidelines in exploring exposures and susceptibilities for AKI screening.
Changes in salivary microbiota due to gastric cancer resection and its relation to gastric fluid microbiota
Authors: Komori Eri , Kato-Kogoe Nahoko , Imai Yoshiro , Sakaguchi Shoichi , Taniguchi Kohei , Omori Michi , Ohmichi Mayu , Nakamura Shota , Nakano Takashi , Lee Sang-Woong , Ueno Takaaki 
Published: September 2023

AbstractGastric cancer is one of the leading causes of death worldwide, and resections are performed to cure the disease. We have previously reported the changes in the gastric microbiota after gastric cancer resection, which may be associated with the oral microbiota; however, the changes in the oral microbiota remain uncharacterized. This study aimed to characterize the changes in the salivary microbiota caused by gastric cancer resection and to evaluate their association with the gastric fluid microbiota. Saliva and gastric fluid samples were collected from 63 patients who underwent gastrectomy before and after surgery, and a 16S rRNA metagenomic analysis was performed to compare the microbiota composition. The number of bacterial species in the salivary microbiota decreased, and the bacterial composition changed after the resection of gastric cancer. In addition, we identified several bacterial genera that varied significantly in the salivary microbiota, some of which also showed similar changes in the gastric fluid microbiota. These findings indicate that changes in the gastric environment affect the oral microbiota, emphasizing the close association between the oral and gastric fluid microbiota. Our study signifies the importance of focusing on the oral microbiota in the perioperative period of gastrectomy in patients with gastric cancer.
Treatment patterns and healthcare resource utilization for triple negative breast cancer in the Brazilian private healthcare system: a database study
Authors: Carlos Souto Maior Borba Maria Amelia , de Mendonça Batista Paula , Falcão Almeida Milena , do Carmo Rego Maria Aparecida , Brandão Serra Fernando , Barbour Oliveira Julio Cesar , Nakajima Karina , Silva Julian Guilherme , Amorim Gilberto 
Published: September 2023

AbstractIn Brazil, data on the management of triple negative breast cancer (TNBC) as well as the burden of the disease in terms of health care resources utilization (HCRU) are scarce. To characterize the treatment patterns and HCRU associated with the management of Brazilian TNBC patients from the perspective of the private healthcare setting. Patients with at least one claim related to ICD-10 C50 from January 2012 until December 2017, and at least one claim for breast cancer treatment were assessed from a private claims database and classified as early and locally advanced, or metastatic. All patients with hormone and/or targeted therapy were excluded. Three thousand and four patients were identified, of which 82.8% were diagnosed in early and locally advanced stages. For early and locally advanced TNBC patients, 75.3% were treated in an adjuvant setting, mainly with anthracycline regimes. For mTNBC patients, bevacizumab regimens were the main treatment prescribed. More than 48% of mTNBC patients were switched to a second line of treatment. HCRU was higher for mTNBC patients when compared to early and locally advanced patients, with higher costs for metastatic disease management. The treatment setting has little influence on the HCRU pattern or the cost of disease management. The highest burden of disease was observed for metastatic management.
Sodium nitroprusside improved the quality of Radix Saposhnikoviae through constructed physiological response under ecological stress
Authors: Song Xiao-Wen , Yao Yao , Yu Peng-Cheng , Zhang Wei , Liu Wen-Fei , Wang Li-Yang , Zhao Kai , Lu Jin-Cai , Meng Xiang-Cai 
Published: September 2023

AbstractThe ecological significance of secondary metabolites is to improve the adaptive ability of plants. Secondary metabolites, usually medicinal ingredients, are triggered by unsuitable environment, thus the quality of medicinal materials under adversity being better. The quality of the cultivated was heavily declined due to its good conditions. Radix Saposhnikoviae, the dried root of Saposhnikovia divaricata (Turcz.) Schischk., is one of the most common botanicals in Asian countries, now basically comes from cultivation, resulting in the market price being only 1/10 to 1/3 of its wild counterpart, so improving the quality of cultivated Radix Saposhnikoviae is of urgency. Nitric oxide (NO) plays a crucial role in generating reactive oxygen species and modifying the secondary metabolism of plants. This study aims to enhance the quality of cultivated Radix Saposhnikoviae by supplementing exogenous NO. To achieve this, sodium nitroprusside (SNP) was utilized as an NO provider and applied to fresh roots of S. divaricata at concentrations of 0.03, 0.1, 0.5, and 1.0 mmol/L. This study measured parameters including the activities of antioxidant enzymes, secondary metabolite synthesis enzymes such as phenylalanine ammonia-lyase (PAL), 1-aminocyclopropane-1-carboxylic acid (ACC), and chalcone synthase (CHS), as well as the contents of NO, superoxide radicals (O2·−), hydrogen peroxide (H2O2), malondialdehyde (MDA), and four secondary metabolites. The quality of Radix Saposhnikoviae was evaluated with antipyretic, analgesic, anti-inflammatory effects, and inflammatory factors. As a result, the NO contents in the fresh roots were significantly increased under SNP, which led to a significant increase of O2·−, H2O2, and MDA. The activities of important antioxidant enzymes, including superoxide dismutase (SOD), catalase (CAT), and peroxidase (POD), were found to increase as well, with their peak levels observed on the 2nd and 3rd days. PAL, ACC, and CHS activities were also significantly enhanced, resulting in the increased secondary metabolite contents of Radix saposhnikoviae in all groups, especially the 0.5 mmol/L SNP. The four active ingredients, prim-O-glucosylcimifugin, cimifugin, 4′-O-β-d-glucosyl-5-O-methylvisamminol, and sec-O-glucosylhamaudol, increased by 88.3%,325.0%, 55.4%, and 283.8%, respectively, on the 3rd day. The pharmaceutical effects of Radix Saposhnikoviae under 0.5 mmol/L SNP were significantly enhanced. Exogenous SNP can induce the physiological response of S. divaricata under adverse conditions and significantly improve the quality of Radix Saposhnikoviae.
Comprehensive health risk analysis of heavy metal pollution using water quality indices and Monte Carlo simulation in R software
Authors: Badeenezhad Ahmad , Soleimani Hamed , Shahsavani Samaneh , Parseh Iman , Mohammadpour Amin , Azadbakht Omid , Javanmardi Parviz , Faraji Hossein , Babakrpur Nalosi Kamal 
Published: September 2023

AbstractRapid urbanization, population growth, agricultural practices, and industrial activities have led to widespread groundwater contamination. This study evaluated heavy metal contamination in residential drinking water in Shiraz, Iran (2021). The analysis involved 80 groundwater samples collected across wet and dry seasons. Water quality was comprehensively assessed using several indices, including the heavy metals evaluation index (HEI), heavy metal pollution index (HPI), contamination degree (CD), and metal index (MI). Carcinogenic and non-carcinogenic risk assessments were conducted using deterministic and probabilistic approaches for exposed populations. In the non-carcinogenic risk assessment, the chronic daily intake (CDI), hazard quotient (HQ), and hazard index (HI) are employed. The precision of risk assessment was bolstered through the utilization of Monte Carlo simulation, executed using the R software platform. Based on the results, in both wet and dry seasons, Zinc (Zn) consistently demonstrates the highest mean concentration, followed by Manganese (Mn) and Chromium (Cr). During the wet and dry seasons, 25% and 40% of the regions exhibited high CD, respectively. According to non-carcinogenic risk assessment, Cr presents the highest CDI and HQ in children and adults, followed by Mn, As and HI values, indicating elevated risk for children. The highest carcinogenic risk was for Cr in adults, while the lowest was for Cd in children. The sensitivity analysis found that heavy metal concentration and ingestion rate significantly impact both carcinogenic and non-carcinogenic risks. These findings provide critical insights for shaping policy and allocating resources towards effectively managing heavy metal contamination in residential drinking water.
Optimal operation of multiple integrated energy systems based on a hybrid Taguchi‐compact salp swarm algorithm
Authors: Fu Yang , Shan Jie , Li Zhenkun , Xie Bolin 
Published: September 2023

AbstractWith the rapid development of integrated energy system (IES), it has become a trend to form multiple integrated energy systems (MIESs) in a certain region. However, there is a lack of coordination and cooperation among MIESs. This paper proposes an optimal operation model of MIESs with four cost objectives, which focuses on energy interaction among MIESs. As a non‐linear and large optimization problem, it is difficult for conventional mathematical methods to solve. Hence, this paper proposes a hybrid Taguchi‐compact salp swarm algorithm (TCSSA). The compact technique can save the operation memory of model. Taguchi method can improve the convergence speed and solution accuracy of model. The proposed algorithm is tested on 28 benchmark functions and applied to optimal operation of MIESs. Results demonstrate that: (1) compared with other famous algorithms, TCSSA can provide more efficient execution and better solutions. (2) The optimal operation of MIESs based on TCSSA can achieve the complementary of energy advantages, which effectively reduces the total cost of MIESs (up to 9.67%).
New insights on the latest Messinian-to-Piacenzian stratigraphic series from the Dahra Massif (Lower Chelif Basin, Algeria): Lago Mare, reflooding and bio-events
Authors: Atik Asma , Mansouri Mohamed El Habib , Bessedik Mostefa , Osman Mohammed Kamel , Belkebir Lahcene , Saint Martin Jean-Paul , Chaix Christian , Belkhir Ayoub , Gorini Christian , Belhadji Ahmed , Satour Linda 
Published: September 2023

Geological investigations carried out on the Dahra Massif have revealed sedimentary changes and bioevents characterizing the post-gypsum detrital sediments (from Messinian to Piacenzian), which are followed by the Trubi equivalent Pliocene marls or white marly limestones.
Structured into two superimposed steps, the late Messinian deposits yielded two successive ostracod assemblages. They indicate a brackish environment for the lower and a fairly open shallow brackish environment for the second. Based on their ostracod content, assemblage 1 (Cyprideis, Loxoconcha muelleri) corresponds to the Lago Mare biofacies 1 of the Apennine foredeep, which is correlated with the Lago Mare 1 episode dated between 5.64 and 5.60 Ma. Assemblage 2 (Loxocorniculina djafarovi) is referred to the Lago Mare biofacies 2 described in the same region. It is correlated with the Lago Mare 3 episode, dated between 5.46 and 5.33 Ma.
Moreover, the stratigraphic succession is marked by a major discontinuity indicated by a hardground, separating step 1 from step 2 and corresponding to the ostracod assemblages 1 and 2, respectively. This discontinuity is considered here to be equivalent to the Messinian Erosional Surface, already evidenced in the region and widely known around the Mediterranean Basin.
These late Messinian deposits and their ostracod assemblage 2, notably the detrital sedimentation with Ceratolithus acutus, Globorotalia margaritae, Reticulofenestra cisnerosii document a marine incursion into the Lower Chelif Basin, corresponding to the latest Messinian marine reflooding of the Mediterranean Basin, that happened before the earliest Zanclean R. cisnerosii occurrence. Finally, the bioevents evidenced in the Dahra Massif, reinforce the evidence of the late Messinian Lago Mare 3 episode, and support the ante-Zanclean age of the marine reflooding of the Mediterranean.
The overlying deposits are marked by coral constructions (cf. Cladocora cf. caespitosa, Dendrophyllia sp) never described before and covering the entire early Zanclean, testifying the existence, at that time, of warm enough conditions, which may correspond to the marine isotopic stage TG5.
Proposal of a modified tip apex distance for prediction of lag screw cut-out in trochanteric hip fractures
Authors: Selim Amr , Al-Hadithy Nawfal , Diab Nader M. , Ahmed Abdulla Mohamed , Kader Khaled Fawzy Abdel , Hegazy Mohamed , Azeem Hazem Abdel , Barakat Ahmed Samir 
Published: September 2023

Introduction: Lag screw cut-out is a serious complication of dynamic hip screw fixation of trochanteric hip fractures. The lag screw position has been acknowledged as one of the important factors affecting the lag screw cut-out. We propose a modification of the Tip Apex Distance (TAD) and hypothesise that it could improve the reliability of predicting lag screws cut-out in these injuries. Materials and Methods: A retrospective study was conducted for hip fracture entries in the period from Jan 2018 to July 2022. A hundred and nine patients were suitable for the final analysis. The modified TAD was measured in millimetres based on the sum of the traditional TAD in the lateral view and the net value of two distances in the AP view, the first distance is from the tip of the lag screw to the opposite point on the femoral head along the axis of the lag screw while the second distance is from that point to the femoral head apex. The first distance is a positive value, whereas the second distance is positive if the lag screw is superior and negative if inferior. A receiver operating characteristic curve was used to evaluate the reliability of the different parameters assessing the lag screw position within the femoral head. Results: Reduction quality, fracture pattern as per the AO/OTA classification, TAD, Calcar Referenced TAD, Axis Blade Angle, Parker’s ration in the AP view, Cleveland Zone 1, and modified TAD were statistically associated with lag screw cut-out. Among the tested parameters, the modified TAD had 90.1% sensitivity and 90.9% specificity for lag screw cut-out at a cut-off value of 25 mm with a P-value < 0.001. Conclusion: The modified TAD had the highest reliability in the prediction of lag screw cut-out. A value ≤ 25 mm could potentially protect against lag screw cut-out in trochanteric hip fractures.
Endovascular Embolization with n-Butyl Cyanoacrylate for Ruptured Distal Posterior Inferior Cerebellar Artery Dissecting Aneurysm
Authors: Shintoku Ryosuke , Marushima Aiki , Okune Sho , Hiramine Takato , Nakao Junzo , Takahashi Toshihide , Hino Tenyu , Hosoo Hisayuki , Ito Yoshiro , Hayakawa Mikito , Ishikawa Eiichi , Matsumaru Yuji 
Published: September 2023

AbstractParent artery occlusion is a definitive treatment method for preventing rebleeding of dissecting aneurysms. We herein report a case of a ruptured distal posterior inferior cerebellar artery (PICA) dissecting aneurysm treated with internal trapping using n-butyl-2-cyanoacrylate (NBCA). A 65-year-old man visited our hospital with a complaint of headache and neck pain that began 1 week before his arrival. He had a history of spontaneous subarachnoid hemorrhage of unknown cause. Computed tomography of the brain revealed a small amount of subarachnoid hemorrhage, and distal subtraction angiogram showed a distal PICA dissecting aneurysm. We placed a guiding catheter in the left vertebral artery and an intermediate catheter in the PICA. A microcatheter was guided toward the proximal side of the aneurysm and was wedged into the parent artery. The dissecting aneurysm was treated with parent artery occlusion using 50% NBCA. The postoperative course was uneventful, and the patient was discharged 3 weeks after treatment without any neurological deficit. Parent artery occlusion with internal trapping using NBCA could be a safe and definitive treatment method for distal PICA dissecting aneurysms. Angiographical evaluation of the collateral network in the distal branch of PICA before embolization and wedged microcatheter technique in the parent artery are important for successful embolization using NBCA.
A Case Series of Gestational Choriocarcinoma with Review of Literature
Authors: Tanneru Anusha , Shetty Vijith , Nandan Neetha 
Published: September 2023

AbstractChoriocarcinoma can be gestational and nongestational. Gestational choriocarcinoma is rare with an incidence of 9.2 in 40,000 pregnancies in Asian population. They can occur following molar, partial molar pregnancy, abortion, or delivery. It is detected by elevated levels of serum beta-human chorionic gonadotropin (beta-hCG) and by imaging modality. The need for histopathological diagnosis for choriocarcinoma is debatable. Six cases of choriocarcinoma are described with variable presentations and outcomes. Out of six cases, three were following vaginal delivery, two were after abortion, and one case was perimenopausal with antecedent pregnancy 10 years ago, unclear whether it was the cause for choriocarcinoma. Brain and lung metastasis were seen in three cases each; one case, which had metastasis to all organs, had worse prognosis and succumbed to the disease. All belonged to high-risk group according to International Federation of Gynaecology and Obstetrics score (8–13). The prognosis is usually very good, provided that prompt diagnosis and treatment are initiated early. Long-term follow-up with beta-hCG levels needs to be done to detect recurrence but it did not act like a prognostic indicator in our case series.
Nonmeningothelial Dural-Based Lesions: A Histopathological Analysis
Authors: Gajaria Pooja K. , Shenoy Asha S. , Goel Naina A. 
Published: September 2023

Abstract
Introduction We report 30 cases of nonmeningothelial dural-based lesions encountered during a 3-year study period.
Materials and Methods We retrospectively reviewed pathology records of patients operated for extra-axial, dural-based lesions during the years 2016 to 2018 and included nonmeningothelial lesions as a part of this study.
Results Among the 3,243 neurosurgical specimens for histopathologic examination, only 30 (0.93%) were “nonmeningothelial dural-based lesions.” Six (20%) patients were in the pediatric age group. Pathologic assessment identified 13 cases of solitary fibrous tumor/hemangiopericytoma (43.3%) and 7 cases of Ewing's sarcoma/primitive neuroectodermal tumor (23.3%). Two cases (6.7%) were of metastasis. Other lesions included a single case each of non-Hodgkin's lymphoma, undifferentiated sarcoma, solitary plasmacytoma, and granulocytic sarcoma. Nonneoplastic lesions included two cases each of Rosai–Dorfman disease and nonspecific inflammatory lesions.
Conclusion Nonmeningothelial dural-based lesions being rare, thorough examination of morphological features is a must by the pathologist, to arrive at the accurate diagnosis. Ancillary tests, if required, should be employed in the context of the morphologic picture.