bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sleep Duration as a Predictor of Suicidal Ideation Among High-Risk Adolescents
Authors: Ratzon Roy , Reiter Joel , Goltser-Dubner Tanya , Segman Ronen , Weisstub Esti Galili , Benarroch Fortunato , Ran Shlomo Rahmani Zwi , Kianski Ella , Giesser Ruth , Weinberg Pnina Blum , Ben-Ari Amichai , Sela Yaron , Nitsan Moriah Bar , Lotan Amit , Shalev Amit 
Published: August 2023

Abstract
Background: Suicide is the second leading cause of death among youth aged 15 to 24, highlighting the need for improved prediction methods for the assessment of suicidal risk. Identifying modifiable risk factors relevant to adolescents is crucial for suicide prevention. Sleep patterns have been linked to suicidality in adults but lack sufficient study in youth.
Objectives: This prospective study aimed to explore the relationship between objectively- and subjectively-measured sleep characteristics and next-day suicidal ideation in at-risk youth.
Methods: Thirty-three adolescents (12-18 years old) admitted to the psychiatric ward post-suicide attempt or due to suicidal intent within the previous month were included. Objective (actigraphy) and subjective (sleep diary) assessments of sleep patterns were conducted for ten consecutive days. Daily suicidal ideation was evaluated through a questionnaire based on the validated C-SSRS interview.
Results: A negative association was observed between total sleep time and expressing a "death wish" the following day. Each one-hour decrease in objectively measured total sleep time increased the odds of a death wish by 40% (Z=-2.55, p=0.011, CI -0.34 [-0.61, -0.08]). Even after adjusting for sedative medication use and self-reported depression severity, a loss of approximately two hours of sleep predicted a two-fold increase in expressing a death wish the next day.
Conclusions: Our study highlights the interplay between sleep patterns and suicidal ideation, with sleep duration playing a significant role. Short sleep duration increases the likelihood of experiencing suicidal ideation the following day among high-risk youth.
Identifying hotspots of endangered wetland bird in the Marsh Al-Dalmaj / Iraq
Authors: Awad¹ Ahmed , Kadhum¹ Safaa A. , Ishak Mohd Yusoff , Hathal Mustafa M. , Hussein Haider M. 
Published: August 2023

Abstract
The escalating human population, urbanization, anthropogenic activities, overhunting of wetland birds, and habitat fragmentation present persistent challenges to the delicate ecosystem. However, Marsh Dalmaj stands as a vital sanctuary for migrating birds, harboring remarkable biodiversity that underscores the need to prioritize the conservation of wetland avifauna. The study spanned from September 2020 to August 2022. Our methodology encompassed several techniques: (KDE) was employed to delineate suitable and non-suitable habitats, Hotspot Modeling determined the fidelity of suitable habitats, the LST and NDVI algorithms were utilized to monitor climate change, the point count protocol (PCP) enabled precise recording of wetland bird species, and the Adaptive Neuro-Fuzzy Inference System (ANFIS) was employed to predict future scenarios over a span of 50 years. In 2021, the average LST in suitable habitats was 42.37°C, accompanied by an NDVI value of 0.33. In contrast, non-suitable habitats exhibited an average LST of 45.5°C and an NDVI of -0.13. Additionally, the Area of Occupancy (AOO) encompassed 50.83 km² of suitable habitat and 93.21 km² of non-suitable habitat, while the Extent of Occurrence (EOO) covered 144.04 km². These findings suggest that the EOO and AOO of wetland birds are nearing endangered status according to the criteria set by the (IUCN). Furthermore, the analysis identified 14 hotspots within the AOO, with confidence levels ranging from 90–99%, signifying areas of significant ecological importance. We conclude from our study that highlights the key pathways of a 50-year scenario, demonstrating the negative impact of continuous climate change, specifically LST, on marsh bird populations and NDVI. Consequently, it is crucial for the Iraq Environmental Ministry (IEM) to play an active and influential role in shaping environmental policies and promoting sustainable management approaches, particularly in conserving the biodiversity of the Marsh Al-Dalmaj region
Extradural removal of the crista galli to prevent CSF rhinorrhea after the basal interhemispheric approach: A technical note
Authors: Morita Shuhei , Numazawa Shinichi , Watanabe Sadayoshi , Kawamata Takakazu , Mori Kentaro 
Published: August 2023

Abstract
Purpose
Crista galli removal during the basal interhemispheric approach is a possible cause of postoperative cerebrospinal fluid rhinorrhea because of the pneumatization of this bony ridge communicating with the frontal sinus. Crista galli can be removed either intradurally or extradurally. We discuss these techniques and describe extradural removal with the intention of preventing postoperative cerebrospinal fluid leak.
Methods
Representative intradural and extradural removal of the crista galli is explained. Intradural removal carries the risk of a dural defect in the anterior skull base, but extradural removal can be achieved without a dural defect.
Results
The anatomical characteristics of the frontal dura mater and falx cerebri allow for the removal of the crista galli without a dural defect.
Conclusion
Extradural removal of the crista galli is preferable to intradural removal to reduce the risk of postoperative cerebrospinal fluid rhinorrhea after the basal interhemispheric approach, especially if the crista (galli) is pneumatized.
Desktop-stereolithography 3D printing of a decellularized extracellular matrix/mesenchymal stem cell exosome bioink for vaginal reconstruction
Authors: Shi Wenxin , Zheng Jiahua , Zhang Jingkun , Dong Xiaoli , Li Zhongkang , Xiao Yanlai , Li Qian , Huang Xianghua , Du Yanfang 
Published: August 2023

Abstract

Abstarct
Background
3D-printing is widely used in regenerative medicine and is expected to achieve vaginal morphological restoration and true functional reconstruction.Mesenchymal stem cells-derived exosomes (MSCs-Exos) were applyed in the regeneration of various tissues.The current study aimed to explore the effctive of MSCs-Exos in vaginal reconstruction.
Results
In this work, hydrogel was designed using decellularized extracellular matrix (dECM) and gelatin methacrylate (GelMA) and silk fibroin (SF).The biological scaffolds was constructed using desktop-stereolithography.The physicochemical properties of the hydrogels were evaluated.It was observed that the sustained release property of exosomes in the hydrogel both in vitro and in vitro.The results revealed that 3D scaffold encapsulating exosomes expressed significant effects on the vascularization and musule regeneration of the regenerative vagina tissue.Also, MSCs-Exos strongly promoted vascularization in the vaginal reconstruction of rats,which may through the PI3K/AKT signaling pathway.
Conclusions
Our results indicated that the 3D-printed, lumenal scaffold encapsulating exosomes might be used as a cell-free alternative treatment strategy for vaginal reconstruction.
Automatic mud diapir detection using ANFIS Expert Systems algorithm; a case study in the Gorgan plain, Iran
Authors: Hedayat Bahareh , Monfared Mehrdad Soleimani , Losada Luis Somoza 
Published: August 2023

Abstract

Automatic seismic data interpretation is a significant method in oil and gas exploration. Seismic data interpretation makes the decision-making process difficult due to the complexities of the subsurface structures and the extent of related knowledge, and using the expert system method in seismic data interpretation can solve this problem. An expert system is a knowledge-based system that applies its knowledge in a complex and specific area and acts as an expert end-user consultant. This study includes investigating steps of designing an ANFIS expert system for mud diapirs detection with seismic data analysis, due to their importance in the exploration of hydrocarbon reservoirs in the high-potential region of Gorgan Plain. The expert system design process to identify mud diapirs on seismic sections was modeled in two approaches including manual and automatic seismic data interpretation. In the first approach, the experience of the expert was collected by manual interpretation of training data and used to create a knowledge base and inference of the expert system in the second approach. The validation verified the accuracy of this method with an average accuracy of 90.1% according to using minimum knowledge to develop a knowledge base of the designed ANFIS expert system.
Are Males and Minorities Worse Off? How Demographics Fit into College Student Psychiatric Medication Dissatisfaction
Authors: Borgogna Nicholas , Aita Stephen L. 
Published: August 2023

Abstract

There is a need to better understand factors associated with psychiatric medication dissatisfaction in college students. We explored cultural and identity factors associated with psychiatric medication dissatisfaction in isolation and in combination. We also explored relevant covarying factors such as trauma history and psychotherapy utilization. Data were collected from the 2020–2021 as part of the Healthy Minds Study, involving n = 11,421 college students who reported taking medication for a psychiatric disorder. Categorical medication dissatisfaction was modest, n = 847 (7.4%). Results indicated identifying as a biological male and/or a Person-of-Color (with exception to Asian/Asian American students) were associated with significantly greater medication dissatisfaction relative to referent groups (female and White participants). Being married/partnered and having a history of psychotherapy treatment were significantly associated with psychiatric medication satisfaction. Additionally, experiencing emotional, sexual, and/or physical trauma were each associated with higher odds of psychiatric medication dissatisfaction. Results were consistent in isolation and in combination (adjusted for all variables simultaneously). Our findings suggest contextual factors of identity, treatment history, and trauma history as uniquely associated with psychiatric medication dissatisfaction in college students. Treatment providers are encouraged to take a holistic approach when considering intervention recommendations.
MPF and Diffusion Mapping Brain Microstructure in Patients with Major Depressive Disorder
Authors: Abramova Victoria , Petrovskiy Evgeniy , Savelov Andrey , Mazhirina Kseniya , Korostyshevskaya Aleksandra 
Published: August 2023

Abstract

Previous studies have illustrated that the cingulate and prefrontal gyrus, along with the amygdala, are involved in emotional processing and the development of abnormal emotional responses in depression. In this study, we utilized advanced quantitative MRI techniques, specifically Diffusion Tensor Imaging, Diffusion Kurtosis Imaging, and Мacromolecular Proton Fraction Mapping, to investigate microstructural differences and alterations in these regions in patients diagnosed with Major Depressive Disorder. Our findings revealed no significant interaction between Мacromolecular proton fraction Mapping and diffusion kurtosis parameters with depressive disorder. However, patients with Major Depressive Disorder exhibited a statistically significant increase in mean, axial and radial diffusivity (F = 6.3, p = 0.01, F = 5.0, p = 0.03, F = 7.08, p = 0.01, respectively) in the bilateral amygdala compared to healthy controls, as well as in mean and radial diffusivity in the anterior cingulate cortex (F = 5.61, p = 0.02, F = 7.08, p = 0.01, respectively). These results suggest that altered molecular diffusion characteristics in the amygdala and in the anterior cingulate cortex may be specifically associated with Major Depressive Disorder. The identification of novel markers for brain microstructural changes could have implications for early prediction of depressive disorder. Our study demonstrates the utility of new quantitative MRI techniques in assessing structural alterations on the molecular level in the brain and provides valuable insights into the pathophysiology of depression.
Disulfidptosis-related lncRNAs are potential biomarkers for predicting prognoses in patients with hepatocellular carcinoma
Authors: Ma Guiping , Liu Bowen , Li Xiaobin , Li Feng , Su Xiaopeng , Ran Yun , Hu Shiping 
Published: August 2023

Abstract
Objective: Hepatocellular carcinoma (HCC) is the most common type of liver cancer. Disulfidptosis is a newly discovered mechanism of programmed cell death. However, the role of disulfidptosis - related lncRNAs (DRlncRNAs) in HCC remains unclear. The purpose of this study is to establish the prognostic model of DRlncRNAs and explore its prognostic value in HCC.
Materials and methods: The relevant clinical data and RNA-seq were obtained from the Cancer Genome Atlas (TCGA) database. The DRlncRNAs were identified via univariate and multivariate Cox regression, lasso algorithm analysis, and then established the prognostic model. Kaplan-Meier survival analysis, receiver operating characteristic (ROC) curves, principal component analysis (PCA), univariate and multivariate Cox regression analysis, functional enrichment annotation and the nomogram were used to assess the reliability of risk model. Furthermore, the potential immunotherapeutic signatures and drug sensitivity prediction were also performed. The RT-qPCR was applied to identify the expression of DRlncRNAs.
Results:We constructed a prognostic model with 7 DRlncRNAs and proved the model could well predict the survival and prognosis of HCC patients. Immune correlation analysis suggested that low-risk patients had better immunotherapeutic outcomes. Drug prediction showed that Erlotinib, Gefitinib, Savolitinib, Osimertinib, Lapatinib, Afatinib and Crizotinib were more effective in low-risk patients; Sorafenib, Selumetinib, and Axitinib were more effective in high-risk patients. Finally, the expression of DRlncRNAs in normal liver and HCC cell lines were testified by RT-qPCR.
Discussion and Conclusions: We constructed a risk model and provided a new direction for diagnosing and treating HCC.
Dielectric study of a binary mixture of acrylonitrile with 1,4-dioxane using a TDR
Authors: Dongre D. G. , Gubre A. G. , Garad N. P. , Saknure S. H. , Kumbharkhane A. C. 
Published: August 2023

Abstract
The frequency-dependent complex permittivity spectra (CPS) of acrylonitrile (ACRN) and 1,4-dioxane (DX) binary mixture in the range from 10 MHz to 30 GHz were measured using the time domain reflectometry (TDR) technique. Experimentally obtained CPS was fitted into the Debye equation. Dielectric relaxation behaviors that depend on temperature and concentration were discussed. The obtained dielectric parameters are reported. The Kirkwood correlation and Bruggeman factor have been used to analyze the molecular association and hydrogen bonding interactions in the mixture.
Telegenetics in cardiovascular disease: patient experience and follow-up care
Authors: Temares Dani S. , Liang Lusha W. , Bergner Amanda L. , Reilly Muredach , Kalia Isha 
Published: August 2023

Abstract
Telegenetics played an important role in providing genetic services to patients during the COVID-19 pandemic. In particular, at our institution it enabled us to expand our genetic counseling and testing services to non-local family members of patients outside of our prior catchment area. However, as telegenetics continues to be utilized even as social distancing is no longer required, further information is needed regarding the impact of this modality on patient experience and outcomes within cardiogenetics. This study qualitatively explored the experiences of 12 genotype positive individuals who underwent genetic counseling and testing via telegenetics during the first 22 months of the COVID-19 pandemic and compared the outcomes of local vs. non-local patients. Both local and non-local participants discussed similar benefits and drawbacks to the use of technology in telegenetics and overall found the use of telegenetics and at-home genetic testing to be convenient. Both groups also noted having to make changes in their daily lives and future planning as a consequence of the positive genetic testing results. However, access to follow-up care differed between local and non-local participants, with more local participants having scheduled and attended appointments with the appropriate medical providers compared to non-local participants. Supplying non-local patients access to remote cardiogenetic testing may therefore careful consideration in how to ensure proper follow-up care for genotype positive patients and may require the involvement of national professional or patient-centered organizations to help streamline the referral process.
Periodic points of self-maps of a space with π1X = Zps
Authors: Jezierski Jerzy , Zhao Xuezhi 
Published: August 2023

Abstract

The crucial homotopy invariants in Nielsen periodic point theory are the numbers: NPn(f), which is a lower bounds of the number of periodic points of length equal n, and NFn(f) a lower bounds of the number of periodic points of length dividing n. Here f : X → X a self-map of a compact polyhedron.
We derive the formulae of these invariants for self-map of the polyhedron with the fundamental group π1M = Zps and all irreducible classes are essential.
Pengaruh Senam Aerobik dan Konseling Gizi terhadap Profil Kolesterol Total Wanita Obesitas
Authors: Muslicha Chamida Nur , Sugiyanti Dina , Hartanti Dwi 
Published: August 2023

The aim of this study was to determine the difference of obese women’s cholesterol after being given combination of aerobic exercise and nutritional counseling interventions. This pre-experimental study with one group pretest and posttest design was done in Ngadiluwih Village, Matesih Sub-district, Karanganyar District and involved 18 womens who have IMT greather than 25 kg/m2 and selected by purposive sampling technique. The interventions that given to the samples are combinations between 60 minutes aerobic three times a week and nutritional counseling once a week. The data taken were pre-post cholesterol total and analyzed with Wilcoxon test of IBM SPSS Statistics 25 Commuter License. The average of sample’s cholesterol before interventions was 209.56mg / dL while after intervention decreased by 15mg / dL to 194.56mg / dL (p = 0.001). This value indicated that there was a difference in sample’s cholesterol after interventions. Aerobic exercise three times a week and nutritional counseling once a week can be used as an alternative treatment for hypercholesterolemia in obese women.Tujuan dari penelitian ini untuk mengetahui pengaruh intervensi berupa senam aerobik dan konseling gizi terhadap profil kolesterol wanita obesitas. Penelitian ini menggunakan desain eksperimental dengan one group pretest and posttest. Berdasarkan hasil perhitungan sampel dengan teknik purposive sampling didapatkan sampel sebanyak 18 orang wanita yang memiliki nilai Indeks Massa Tubuh (IMT) di atas 25 kg/m2. Penelitian ini dilakukan di Desa Ngadiluwih, Kecamatan Matesih, Kabupaten Karanganyar. Sampel penelitian diberikan kombinasi intervensi berupa senam aerobik 3 kali seminggu selama 60 menit dan konseling gizi 1 kali seminggu. Data yang diambil adalah profil kolesterol total pretest-posttest dan dianalisis menggunakan uji Wilcoxon pada IBM SPSS Statistics 25 Commuter License. Rerata profil kolesterol sampel sebelum intervensi yakni 209,56 mg/dL sedangkan setelah intervensi mengalami penurunan sebesar 15 mg/dL menjadi 194,56 mg/dL (p0,001). Nilai p yang diperoleh (p0,001) tersebut menunjukkan bahwa terdapat perbedaan profil kolesterol total sampel setelah diberikan kombinasi intervensi. Kombinasi intervensi berupa senam aerobik 3 kali seminggu dan konseling gizi 1 kali seminggu dapat dijadikan alternatif dalam menangani hiperkolesterolemia pada wanita obesitas.
Drinking water quality and associated factors in Bahir Dar City and the surrounding rural areas, Northwest Ethiopia: a community-based cross-sectional study
Authors: Sitotaw Baye , Teferi Derebew , Wossen Zinash , Tadesse Beselam 
Published: August 2023

Abstract
In low-income countries like Ethiopia, waterborne illnesses have posed serious public health problems. This study aimed to evaluate drinking water quality (DWQ) and associated factors in Bahir Dar City and the surrounding rural areas in northwest Ethiopia. A cross-sectional study was conducted from January to June 2022 to determine coliform counts and basic physicochemical parameters from the drinking water samples (DWS) collected from urban, peri-urban, and rural sites. A total of 180 DWS were collected from water collection points and households' containers. Potentially pathogenic bacteria were also isolated from fecal coliform (FC)-positive samples and their antibiotic susceptibility profiles were determined. Moreover, the risk factors associated with water quality were assessed. The water quality test results were evaluated against the WHO guidelines for DWQ. Based on the results of this study, only 16.7 and 73.88% of samples met the standards for total coliform and FC, respectively. Moreover, 95.4 and 43% of the isolated bacteria were resistant at least to one of the commonly used antibiotics and multidrug-resistant, respectively. Educating the public on proper drinking water handling, appropriate treatment, and waterline maintenance are needed to safeguard the community from waterborne diseases.
The Prevalence of HLA-B*57 Serotype Associated with Hypersensitivity Reactions in the Treatment of HIV İnfection in the Turkish Population
Authors: Kizmaz Muhammed Ali , Simsek Abdurrahman , Aymak Figen , Akalin Emin Halis , Oral Haluk Barbaros , Budak Ferah 
Published: August 2023

Objectives:
The aim of our study is to reveal the prevalence of HLA-B*57 in the Turkish
population and to provide new perspectives to physicians starting abacavir therapy in HIV patients.

Background:
Abacavir, one of the drugs used to treat HIV infection, can cause hypersensitivity reactions
in some patients. These hypersensitivity reactions have been shown to be associated with the
HLA-B*57:01 allele. High-resolution HLA-B*57:01 scanning has a time and cost disadvantage
compared with low-resolution HLA-B*57 scanning. Before starting abacavir treatment, we will discuss
whether high-resolution scanning is more beneficial in individuals who are positive on HLAB*
57 screening. This is the study with the largest cohort to investigate the prevalence of HLA-B*57
in Turkey.

Methods:
The results of 25 thousand 318 people who applied to Bursa Uludağ University Faculty of
Medicine, Department of Immunology for HLA-B* typing were scanned.

Results:
In our study, the HLA-B*57 serotype was detected in 827 (3.3%) individuals.

Conclusion:
Considering these results, it can be assumed that the prevalence of HLA-B*57:01 in
Turkey is lower than 3.3%. Instead of a high-resolution HLA-B*57:01 scan in all patients starting
abacavir therapy, a high-resolution HLA-B*57:01 scan might be of greater benefit in patients who
are positive on a low-resolution HLA-B*57 scan.
Recent Advances in Total Synthesis of Tetrahydroisoquinoline Alkaloids
Quinocarcin and Lemonomycin
Authors: Guo Ju , Yang Yang , Shen Lanhua , Li Jingyi , Li Fuan , Wang Sifan 
Published: August 2023

Abstract:
Tetrahydroisoquinoline natural products are a kind of alkaloids containing various
pharmacological activities. These structurally diverse alkaloids mainly consist of two subclasses,
monotetrahydroisoquinolines (MTHI) and bistetrahydroisoquinolines (BTHI). Since its family
member, Ecteinascidin-743 (INN: Trabectedin, trade name: Yondelis®), has been approved by
European Union in 2007 and the FDA in 2015 for the treatment of advanced soft tissue tumors, the
research on this kind of natural product is full of new vitality. Quinocarcin and lemonomycin share a
common diazabicyclo[3.2.1]octane framework that belongs to the subclass of MTHI, and their excellent
antitumor activity and challenging architecture have made them an ideal target for total synthesis.
In this short review, the progress in the total synthesis of quinocarcin and lemonomycin is summarized.