bluuebunny/crossref_metadata_2025_split huggingface dataset:
Post-Hospitalization Problems and Nursing Care Needs of Patients who Underwent Thoracolumbar Spine Surgery
Authors: Thapar Geeta , Dhandapani Manju , Singla Navneet , Dhandapani Sivashanmugam 
Published: September 2023

Introduction Thoracolumbar spine surgery is performed to relieve symptoms like radicular pain and numbness caused by conditions such as disc herniation, lumbar canal stenosis, and spondylolisthesis. Objective: To explore the problems experienced and nursing care needs of patients during home care after thoracolumbar spine surgery. Methods An exploratory study was conducted among 50 patients who underwent thoracolumbar spine surgery in Neurosurgery units, PGIMER, Chandigarh, from July 2018 to September 2020. The problems and nursing care needs were assessed by interviewing the participants telephonically, using an interview schedule comprising of (a) patient profile, (b) clinical variables, and (c) questionnaires to assess physical, psychological, functional, and other problems after discharge. Descriptive statistics (mean, frequency, and percentage) were applied to analyze the data. Results The patients experienced physical problems such as pain, numbness in lower limbs, weakness in limbs, and loss of bladder after discharge. The psychological problems that patients faced were early awakening, sleeplessness, worry about physical dependence on others, stress regarding the family’s role responsibility, and anxiety to return to the job. The common functional issues were difficulty in bathing, difficulty in ambulation, dependence in toileting, and the need for assistance in grooming. Furthermore, other problems perceived by patients were difficulty regarding follow-up in OPD, difficulty in understanding postoperative exercises, lack of understanding of postoperative instructions, and difficulty in carrying out wound dressing. Conclusion The findings of the study provide preliminary evidence that patients experience physical, psychological, and functional problems during their home care after thoracolumbar spine surgery. Hence, it is vital to develop strategies to address the issues by developing need-based nursing care guidelines.
Return to Sport After First Metatarsophalangeal Arthrodesis: A Systematic Review
Authors: Baumann Anthony N. , Walley Kempland C. , Kermanshahi Nazanin , Anastasio Albert T. , Holmes James R. , Walton David M. , Talusan Paul G. 
Published: September 2023

Background: First metatarsophalangeal (MTP) arthrodesis is a common surgical intervention for addressing MTP pain and deformity. Despite great interest on the topic of return to sport (RTS) after first MTP arthrodesis in the literature, no systematic review exists on this topic. The purpose of this systematic review is to investigate RTS after first MTP arthrodesis. Methods: This study is a systematic review using PubMed, Web of Science, CINAHL, and MEDLINE from database inception until May 10, 2023. Search algorithm used was (MTPJ OR MTP OR “hallux rigidus” OR cheilectomy OR metatarsal OR metatarsophalangeal) AND (arthrodesis OR fusion) AND sport. Inclusion criteria were surgical intervention of first MTP arthrodesis and outcomes related to sport. Results: Ten articles were included out of 249 articles initially retrieved. Patients (n = 450) had a frequency weighted mean (FWM) age of 58.6 ± 5.1 years with a FWM follow-up time of 32.1 ± 18.9 months. A total of 153 patients (reported in 34.0% of patients) had a FWM postoperative Foot and Ankle Ability Measure Sport score of 70.4 ± 21.8 at final follow-up. For sporting activities reported by multiple studies (running, yoga, golf, hiking, tennis, elliptical, and biking), about 9.8% to 28.1% of patients (n = 69 reports) stated that sporting activity difficulty decreased, 67.2% to 87.5% of patients (n = 340 reports) stated that sporting activity remained the same, and 1.8% to 8.5% of patients (n = 23 reports) stated that sporting activity difficulty increased after first MTP arthrodesis depending on the sporting activity. One article reported RTS time of 11.7 ± 5.1 weeks after first MTP arthrodesis (n = 39). Conclusion: RTS after first MTP arthrodesis is highly variable depending on patient and sport. Numerous different sporting activities have high rates of RTS after first MTP arthrodesis, with a majority of patients reporting similar or increased ability to perform sporting activities after surgery.
In vivo comparison of implantation behavior and laboratory analysis of two preloaded intraocular lens injectors
Authors: Baur Isabella D , Łabuz Grzegorz , Chychko Lizaveta , Yildirim Timur M , Naujokaitis Tadas , Auffarth Gerd U , Khoramnia Ramin 
Published: September 2023

Purpose We evaluated implantation behavior and injector damage of two different IOL injector systems, the Multisert and the AutonoMe. Design Prospective, randomized, comparative study with laboratory investigation. Methods We examined used injectors from 48 bilateral cataract cases and assessed video recordings of each Implantation. All eyes were intraindividually randomized for treatment with one of the two IOL injectors. Implantation videos were reviewed for inadvertent events and the time for different implantation steps was determined. The injector nozzle tips were examined using light and scanning electron microscopy (SEM). Damage was graded using the Heidelberg Score for IOL injector damage (HeiScore). Three months postoperatively, IOLs were assessed for material changes. Results Implantation was without critical events in 96 of 96 eyes. Mean implantation time was 41.90 ± 7.11 s with the Multisert and 52.22 ± 12.06 s with the AutonoMe. In the AutonoMe group, we observed 4 eyes (8.3%) with a failed docking attempt, 28 eyes (58.3%) with a haptic adherence, one case (2.1%) of straight leading haptic and 2 cases (4.2%) of intrawound IOL manipulation. There were no events observed in the Multisert group. The mean HeiScore values were 0.87 ± 0.61 and 3.68 ± 0.47 for the AutonoMe and Multisert. 3 months postoperatively, IOL material changes were absent. Conclusions Both injectors allowed safe and controlled implantation. Using Multisert, implantation behavior was more consistent. The injectors showed different damage profiles with a higher damage score for the Multisert. The study is registered at the German Clinical Trials Register (Deutsches Register Klinischer Studien; reference number: DRKS00007837).
Quality of life, depressive symptoms, suicidal behavior and social support among pregnant adolescents in Mexico
Authors: Soto-Chavarría Enrique , Hidalgo-Rasmussen Carlos , Nieto Lourdes 
Published: September 2023

Background Suicidal behavior in adolescents is a public health problem. Although it has been reported that there is a link between suicidal behavior and Quality of life (QoL), this relationship has not been explored in pregnant adolescents, nor have depressive symptoms been examined as mediators and social support as a moderator in a moderated mediation model. Methods In 2021, 143 pregnant adolescents between 13 and 19 years old from different states in Mexico were evaluated. The KIDSCREEN-52 instrument was applied to evaluate the Health-Related Quality of Life, the scale of expectation of living and dying of Okasha, the Edinburgh Postpartum Depression Scale, the family and partner support scale (AFA-R) and sociodemographic information. Moderated mediation analyses were completed. Results A relationship between QoL and suicidal behavior was found, and that relationship was mediated by depressive symptoms on all eighteen models. In addition, social support from the family moderated the mediation of depressive symptoms in 4 of 9 QoL dimensions, and social support from the partner moderated the mediating effect of depressive symptoms in 8 of 9 QoL dimensions. Conclusion The relationship between QoL and suicidal behavior was consistent with previous studies. The moderating role of social support and the mediation of depressive symptoms on the relationship between QoL and suicidal behavior were also consistent with the literature. Professionals who work with pregnant adolescents should consider both depressive symptoms and social support as important factors that influence QoL and suicidal behaviors.
Prerandomization withdrawals from a Type 2 diabetes self-care support intervention trial are associated with lack of available support person coparticipant
Authors: Roddy McKenzie K. , El-Rifai Merna , LeStourgeon Lauren , Aikens James E. , Wolever Ruth Q. , Greevy Robert A. , Mayberry Lindsay S. 
Published: September 2023

Objectives Dyadic interventions, involving two persons with a preexisting close relationship, offer the opportunity to activate support persons (SPs) to improve health for adults with chronic conditions. Requiring SP coparticipation can challenge recruitment and bias samples; however, the associations between voluntary SP coparticipation and recruitment outcomes across patient characteristics are unknown. Methods The Family/Friend Activation to Motivate Self-care 2.0 randomized controlled trial (RCT) enrolled adults with Type 2 diabetes (T2D) from an academic health system. Participants were asked—but not required—to invite an SP to coenroll. Using data from the electronic health record we sought to describe RCT enrollment in the setting of voluntary SP coparticipation. Results In a diverse sample of adults with (T2D) (48% female, 44% minoritized race/ethnicity), most participants (91%) invited SPs and (89%) enrolled with SPs. However, prerandomization withdrawal was significantly higher among participants who did not have consenting SPs than those who did. Females were less likely to invite SPs than males and more Black PWD were prerandomization withdrawals than randomized. Discussion Voluntary SP coenrollment may benefit recruitment for dyadic sampling; however, more research is needed to understand if these methods systematically bias sampling and to prevent these unintended biases.
The use, perceptions and knowledge of safety of over-the-counter medications during pregnancy in a Canadian population
Authors: Casey E , Velez MP , Gaudet L , Brogly SB 
Published: September 2023

Background: The prevalence of prenatal over-the-counter medication use in Canadian women is unknown. Methods: A cross-sectional study of prenatal over-the-counter medication use and safety knowledge was conducted among pregnant and post-partum women attending an academic hospital obstetrics clinic. Results: Seventy-two women participated; 90.3% were Caucasian, 69.4% had a college/university degree, and 61.1% lived in an urban area. Of the 72 women, 87.5% used over-the-counter medications prenatally, first (55.6%), second (65.3%), and third (47.2%) trimesters, with prenatal acetaminophen use most common (72.2%). Women who used over-the-counter medications 1–0onths before conception were more likely to use over-the-counter medications during pregnancy, and 18% of women initiated over-the-counter medications in pregnancy. Women self-reported a medium level of over-the-counter medication safety knowledge (73.6%) and responded that not all over-the-counter medications are safe during pregnancy (95.8%). Conclusion: Despite limited safety profiles of some over-the-counter medications, pre-conception and prenatal over-the-counter medication use was high. Further research on the risk of over-the-counter medications and combinations in pregnancy is needed to help women to make safe choices during pregnancy.
Streets and Stress: A Pilot Study on How Quality and Design of Streets Impacts on Urban Stress
Authors: Sadeghpoor Fereshteh , Ranjbar Ehsan , Esmaeilinasab Maryam , Valiloo Mir Hojjat Seyed , Nieuwenhuijsen Mark J. 
Published: September 2023

Objectives: To identify how quality and design of streets impacts urban stress. Background: Few studies have comprehensively addressed environmental factors affecting stress in urban public spaces. However, a remarkable portion of our everyday life is spent in public spaces, particularly streets. Method: This study seeks to evaluate the effect of three types of streets as major public spaces on stress. These include a street with the dominance of green spaces (A), a motorist-oriented street (B), and a pedestrian street (C). For this purpose, we selected a group of participants ( n = 16) aged 20-30, with an equal number of men and women who were generally healthy and had normal stress levels. Participants were asked to wear an electroencephalogram (EEG) headset, walk different streets, and answer the Perceived Restorativeness Scale (PRS) and urban design qualities questionnaires. Results: According to the results, participants experienced the highest stress in street type B and the lowest in type A. Conclusions: Green space and vegetation, a sense of security, privacy and coziness, climatic comfort, and safety of space had the most positive effect on stress reduction. Whereas noise pollution, vehicle traffic, and crowdedness were the most critical factors of stress. Finally, our findings suggest that the component of green space has a more significant effect on stress reduction compared with the elimination of vehicle traffic.
User testing to modify the MyHealthyGut digital health application for inflammatory bowel disease
Authors: Erlich Madeline , Lindblad Sarah , Haskey Natasha , Clarkin Darlene Higbee , Dong Taojie , Harvie Ruth , Lunken Genelle , Pirnack Jess , Jacobson Kevan 
Published: September 2023

Introduction Inflammatory bowel disease, characterized by chronic intestinal inflammation, can be subcategorized into Crohn's disease and ulcerative colitis. The treatment for these conditions is unique to each patient and may include lifestyle changes, pharmaceutical intervention, and surgery. Lifestyle changes, such as dietary intervention, are a cornerstone of inflammatory bowel disease symptom management. Given the daily burden of this disease, self-management is paramount in coping with and/or minimizing symptoms. The MyHealthyGut application, successfully proven to be a self-management tool for celiac disease, shows promise for use in an inflammatory bowel disease patient population. Objective To conduct user testing to gather valuable insights for the development of an IBD-focused version of the existing MyHealthyGut app. Methods Participants included inflammatory bowel disease patients and healthcare practitioners. Participants used the application for a 2-week period, followed by participation in a focus group or individual interview to provide feedback. Qualitative questionnaires were administered verbally and feedback was recorded. Thematic analysis techniques were used for data quantification and analysis. Results 15 participants were recruited and enrolled. Of these, 14 participants took part in the focus group and/or individual interviews. The feedback suggested changes related to clinical uses, food and symptom tracking, ease of use, and educational content. All (100%) participants reported that they would either use the application themselves or recommend it to patients, once their suggestions were implemented. Conclusion Through user testing and feedback collection, priorities for app modification were identified. Areas for modification in the app functions and features, ease of use, and content were identified. Once updated to meet the needs of inflammatory bowel disease patients, the MyHealthyGut app may be a useful tool for IBD self-management.
Midterm Outcomes of Operatively and Nonoperatively Managed Achilles Tendon Ruptures in Young Adults
Authors: Ge Laurence , Saunders Noah , Betts Dakota , Holmes James R. , Walton David M. , Talusan Paul G. 
Published: September 2023

Background: There continues to be controversy regarding treatment options for Achilles tendon ruptures (ATR). The aim of our study is to compare outcomes between operatively and nonoperatively managed Achilles ruptures in young adults (age 18-30 years), which has not been previously evaluated. Methods: At a single institution, all patients aged 18-30 years at time of injury who underwent treatment for an acute ATR from 2014 to 2021 were evaluated. Medical records were reviewed to collect demographics, dates of injury and treatment, smoking status, body mass index (BMI), Charlson Comorbidity Index (CCI), rate of deep venous thrombosis (DVT) after treatment, and rate of rerupture. Patients then completed Patient-Reported Outcomes Measurement Information System (PROMIS) physical function (PF) and pain interference (PI) questionnaires. Mann-Whitney nonparametric testing was used to evaluate for any statistical differences in PROMIS scores. Results: Sixty-six operative patients qualified and 28 (42%) participated. Thirty-seven nonoperative patients qualified and 14 (38%) participated. All patients had a CCI of 0. One patient in the operative cohort and 2 in the nonoperative reported active smoking. In the operative and nonoperative cohorts, respectively, the average age was 24.4 and 27.8 years; average BMI 26.5 (SD = 4.8) and 27.3 (SD = 4.3, P = .52); DVT rates 4 (6.1%) and 2 (5.4%); and rerupture rates 2 (3.0%) and 1 (2.7%), respectively. PROMIS scores did not differ in the operative and nonoperative groups: PROMIS PF mean of 60.4 (SD = 9.8) and 62.9 (SD = 9.1), respectively ( P = .33); as well as PROMIS PI mean of 44.6 (SD = 5.9) and 43.9 (SD = 6.5), respectively ( P = .59). Conclusion: This study should be interpreted with the understanding that we had a considerable loss to follow-up rate. In the study cohort, we found that young adults with ATR may be considered for either operative or nonoperative management. Rates of DVT, rates of rerupture, and PROMIS scores were not dissimilar between the 2 cohorts. Level of Evidence: Level III, retrospective cohort study.
Characterization of the mitochondrial Huso huso genome and new aspects of its organization in the presence of tandem repeats in 12S rRNA
Authors: Dadkhah Khadijeh , Mianji Ghodrat Rahimi , Barzegar Ali , Farhadi Ayoub 
Published: September 2023

Abstract
Background
The sturgeon group has been economically significant worldwide due to caviar production. Sturgeons consist of 27 species in the world. Mitogenome data could be used to infer genetic diversity and investigate the evolutionary history of sturgeons. A limited number of complete mitogenomes in this family were sequenced. Here, we annotated the mitochondrial Huso huso genome, which revealed new aspects of this species.

Results
In this species, the mitochondrial genome consisted of 13 genes encoding proteins, 22tRNA and 2rRNA, and two non-coding regions that followed other vertebrates. In addition, H. huso had a pseudo-tRNA-Glu between ND6 and Cytb and a 52-nucleotide tandem repeat with two replications in 12S rRNA. This duplication event is probably related to the slipped strand during replication, which could remain in the strand due to mispairing during replication. Furthermore, an 82 bp repeat sequence with three replications was observed in the D-loop control region, which is usually visible in different species. Regulatory elements were also seen in the control region of the mitochondrial genome, which included termination sequences and conserved regulatory blocks. Genomic compounds showed the highest conservation in rRNA and tRNA, while protein-encoded genes and nonencoded regions had the highest divergence. The mitochondrial genome was phylogenetically assayed using 12 protein-encoding genes.

Conclusions
In H. huso sequencing, we identified a distinct genome organization relative to other species that have never been reported. In recent years, along with the advancement in sequencing identified more genome rearrangements. However, it is an essential aspect of researching the evolution of the mitochondrial genome that needs to be recognized.
De novo assembly and annotation of the singing mouse genome
Authors: Smith Samantha K. , Frazel Paul W. , Khodadadi-Jamayran Alireza , Zappile Paul , Marier Christian , Okhovat Mariam , Brown Stuart , Long Michael A. , Heguy Adriana , Phelps Steven M. 
Published: September 2023

AbstractBackgroundDeveloping genomic resources for a diverse range of species is an important step towards understanding the mechanisms underlying complex traits. Specifically, organisms that exhibit unique and accessible phenotypes-of-interest allow researchers to address questions that may be ill-suited to traditional model organisms. We sequenced the genome and transcriptome of Alston’s singing mouse (Scotinomys teguina), an emerging model for social cognition and vocal communication. In addition to producing advertisement songs used for mate attraction and male-male competition, these rodents are diurnal, live at high-altitudes, and are obligate insectivores, providing opportunities to explore diverse physiological, ecological, and evolutionary questions.ResultsUsing PromethION, Illumina, and PacBio sequencing, we produced an annotated genome and transcriptome, which were validated using gene expression and functional enrichment analyses. To assess the usefulness of our assemblies, we performed single nuclei sequencing on cells of the orofacial motor cortex, a brain region implicated in song coordination, identifying 12 cell types.ConclusionsThese resources will provide the opportunity to identify the molecular basis of complex traits in singing mice as well as to contribute data that can be used for large-scale comparative analyses.
Genome-wide landscape of runs of homozygosity and differentiation across Egyptian goat breeds
Authors: Sallam Ahmed M. , Reyer Henry , Wimmers Klaus , Bertolini Francesca , Aboul-Naga Adel , Braz Camila U. , Rabee Alaa Emara 
Published: September 2023

AbstractUnderstanding the genomic features of livestock is essential for successful breeding programs and conservation. This information is scarce for local goat breeds in Egypt. In the current study, genomic regions with selection signatures were identified as well as runs of homozygosity (ROH), genomic inbreeding coefficients (FROH) and fixation index (FST) were detected in Egyptian Nubian, Damascus, Barki and Boer goat breeds. A total of 46,268 SNP markers and 337 animals were available for the genomic analyses. On average, 145.44, 42.02, 87.90 and 126.95 ROHs were detected per individual in the autosomal genome of the respective breeds. The mean accumulative ROH lengths ranged from 46.5 Mb in Damascus to 360 Mb in Egyptian Nubian. The short ROH segments (< 2 Mb) were most frequent in all breeds, while the longest ROH segments (> 16 Mb) were exclusively found in the Egyptian Nubian. The highest average FROH was observed in Egyptian Nubian (~ 0.12) followed by Boer (~ 0.11), while the lowest FROH was found in Damascus (~ 0.05) and Barki breed (~ 0.03). The estimated mean FST was 0.14 (Egyptian Nubian and Boer), 0.077 (Egyptian Nubian and Barki), 0.075 (Egyptian Nubian and Damascus), 0.071 (Barki and Boer), 0.064 (Damascus and Boer), and 0.015 (Damascus and Barki), for each pair of breeds. Interestingly, multiple SNPs that accounted for high FST values were observed on chromosome 6 in regions harboring ALPK1 and KCNIP4. Genomic regions overlapping both FST and ROH harbor genes related to immunity (IL4R, PHF23, GABARAP, GPS2, and CD68), reproduction (SPATA2L, TNFSF12, TMEM95, and RNF17), embryonic development (TCF25 and SOX15) and adaptation (MC1R, KDR, and KIT), suggesting potential genetic adaptations to local environmental conditions. Our results contribute to the understanding of the genetic architecture of different goat breeds and may provide valuable information for effective preservation and breeding programs of local goat breeds in Egypt.