bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence and Natural History of Segmental Colitis Associated With Diverticulosis
Authors: Tursi Antonio , Piovani Daniele , Brandimarte Giovanni , Di Mario Francesco , Elisei Walter , Picchio Marcello , Allegretta Leonardo , Annunziata Maria Laura , Bafutto Mauro , Bassotti Gabrio , Bianco Maria Antonia , Colucci Raffaele , Conigliaro Rita , Dumitrascu Dan L. , Escalante Ricardo , Ferrini Luciano , Forti Giacomo , Franceschi Marilisa , Graziani Maria Giovanna , Lammert Frank , Latella Giovanni , Maconi Giovanni , Compare Debora , Nardone Gerardo , Camara De Castro Oliveira Lucia , Chaves Oliveira Enio , Papagrigoriadis Savvas , Pietrzak Anna , Pontone Stefano , Stundiene Ieva , Pranzo Giuseppe , Reichert Matthias Christian , Rodinò Stefano , Regula Jaroslaw , Scaccianoce Giuseppe , Scaldaferri Franco , Vassallo Roberto , Zampaletta Costantino , Zullo Angelo , Spaziani Erasmo , Bonovas Stefanos , Papa Alfredo , Danese Silvio ,   DICA International Group
Published: June 2023

INTRODUCTION:
We assessed the prevalence and clinical outcomes of segmental colitis associated with diverticulosis (SCAD) in patients with newly diagnosed diverticulosis.

METHODS:
A 3-year international, multicenter, prospective cohort study was conducted involving 2,215 patients.

RESULTS:
SCAD diagnosis was posed in 44 patients (30 male patients; median age: 64.5 years; prevalence of 1.99%, 95% confidence interval, 1.45%–2.66%). Patients with SCAD types D and B showed worse symptoms, higher fecal calprotectin values, needed more steroids, and reached less likely complete remission.

DISCUSSION:
Although SCAD generally had a benign outcome, types B and D were associated with more severe symptoms and worse clinical course.
Ectopic thyroid tissue in the breast: A case report
Authors: Gong Zheng , Yang Yan , Liu Zegang 
Published: June 2023

Abstract
Ectopic thyroid tissue is a rare condition manifested as the appearance of thyroid tissue outside the thyroid gland. Here, we report a case of ectopic thyroid tissue in the breast. A 48-year-old Chinese woman who was diagnosed with breast cancer received modified radical mastectomy. A thyroid tissue was found on subsequent pathological examination. The ectopic thyroid tissue was confirmed by immunohistochemistry staining of thyroid biomarkers, including thyroglobulin, thyroid transcription factor-1, and thyroid peroxidase. Currently, abnormal thyroid anlage descent is the main theory to explain ectopic thyroid tissue, especially lingual thyroid. However, it is far-fetched to explain the pathogenesis of ectopic thyroid tissues existed in organs or tissues far from thyroid such as iris, cardiac, pulmonary, duodenal, adrenal, and vertebral. Here, we reviewed the previous cases of ectopic thyroid tissue in breast and proposed a “entoderm migration” theory to explain distant ectopic thyroid tissues based on embryonic development perspective.
The MBL2 genotype relates to COVID-19 severity and may help to select the optimal therapy
Authors: Scialò Filippo , Cernera Gustavo , Esposito Speranza , Pinchera Biagio , Gentile Ivan , Di Domenico Marina , Bianco Andrea , Pastore Lucio , Amato Felice , Castaldo Giuseppe 
Published: June 2023

Abstract

Objectives
Sars-CoV-2 acute infection is clinically heterogeneous, ranging from asymptomatic cases to patients with a severe, systemic clinical course. Among the involved factors age and preexisting morbidities play a major role; genetic host susceptibility contributes to modulating the clinical expression and outcome of the disease. Mannose-binding lectin is an acute-phase protein that activates the lectin-complement pathway, promotes opsonophagocytosis and modulates inflammation, and is involved in several bacterial and viral infections in humans. Understanding its role in Sars-CoV-2 infection could help select a better therapy.

Methods
We studied MBL2 haplotypes in 419 patients with acute COVID-19 in comparison to the general population and related the haplotypes to clinical and laboratory markers of severity.

Results
We recorded an enhanced frequency of MBL2 null alleles in patients with severe acute COVID-19. The homozygous null genotypes were significantly more frequent in patients with advanced WHO score 4–7 (OR of about 4) and related to more severe inflammation, neutrophilia, and lymphopenia.

Conclusions
Subjects with a defective MBL2 genotype (i.e., 0/0) are predisposed to a more severe acute Sars-CoV-2 infection; they may benefit from early replacement therapy with recombinant MBL. Furthermore, a subset of subjects with the A/A MBL genotype develop a relevant increase of serum MBL during the early phases of the disease and develop a more severe pulmonary disease; in these patients, the targeting of the complement may help. Therefore, COVID-19 patients should be tested at hospitalization with serum MBL analysis and MBL2 genotype, to define the optimal therapy.
Self-sampling of blood using a topper and pediatric tubes; a prospective feasibility study for PSA analysis using 120 prostate cancer patients
Authors: van den Brink Nicas , Even Rixt , Delic Enver , van Hellenberg Hubar-Fisher Sarah , van Rossum Huub H. 
Published: June 2023

Abstract

Objectives
Self-collection of blood for diagnostic purposes by blood collection assist devices (BCAD) has gained a lot of momentum. Nonetheless, there are a lack of studies demonstrating the feasibility and reliability of self-collecting capillary blood for routine (immuno)chemistry testing. In this study we describe the topper technology together with pediatric tubes to enable self-collection of blood and investigated its feasibility for PSA testing by prostate cancer patients.

Methods
A total of 120 prostate cancer patients for which a routine follow-up PSA test was requested, were included in this study. Patients received instruction materials and the blood-collection device consisting of a topper, pediatric tube and base-part, and performed the blood collection procedure themselves. Afterwards a questionnaire was filled-in. Finally, PSA was measured on a Roche Cobas Pro.

Results
The overall self-sampling success rate was 86.7 %. Furthermore, when specified per age category, a 94.7 % success rate for patients under 70 years and a 25 % success rate for patients of 80 years and older was observed. Venous and self-collected PSA were highly comparable when analyzed by Passing–Bablok regression with a slope of 0.99 and intercept of 0.00011, Spearmans correlation coefficient (0.998) and average self-collected PSA recovery of 99.8 %.

Conclusions
Evidence is presented that self-collected capillary blood by topper and pediatric tube from the finger is feasible, particularly for patients under 70 years. Furthermore, capillary blood self-sampling did not compromise any of the PSA test results. Future validation in a real-world setting, without supervision and including sample stability and logistics, is required.
Landweber Iterative Method for an Inverse Source Problem of Time-Space Fractional Diffusion-Wave Equation
Authors: Yang Fan , Zhang Yan , Li Xiao-Xiao 
Published: June 2023

Abstract
In this paper, we apply a Landweber iterative regularization method to determine a space-dependent source for a time-space fractional diffusion-wave equation from the final measurement.
In general, this problem is ill-posed, and a Landweber iterative regularization method is used to obtain the regularization solution.
Under the a priori parameter choice rule and the a posteriori parameter choice rule, we give the error estimates between the regularization solution and the exact solution, respectively.
Some numerical results in the one-dimensional and two-dimensional cases show the utility of the used regularization method.
The “neo-intermediation” of large on-line platforms: Perspectives of analysis of the “state of health” of the digital information ecosystem
Authors: de Vivo Isabella 
Published: June 2023

AbstractThe key role played by online platforms in the neo-intermediation of the public debate requires a review of current tools for mapping the digital information ecosystem, highlighting the political nature of such an analysis: Starting from a synoptic overview of the main models of platform governance, we try to understand whether the ongoing European shift towards the Limited Government Regulation (LGR) model will be able to counterbalance the “systemic opinion power” of the giant platforms and restore the “health” of the digital information ecosystem. A close analysis of the European Digital Services Act (DSA) has highlighted some limitations in achieving its goals, because of the features of the LGR on the one hand, and the disruptive features of the algorithmic neo-intermediation phenomenon on the other. Thus, we suggest a tripartite regulatory model, that can be defined as “neo-editorial accountability.” However, increasing users’ critical algorithmic awareness is an essential prerequisite for implementing the suggested template, and mitigating an outstanding effect of the LGR model: the normalization of the ideological assumptions underlying informational capitalism.
Mechanism elucidation for wood sandwich compression from the perspective of yield stress
Authors: Huang Rongfeng , Feng Shanghuan , Gao Zhiqiang , Liu Hao 
Published: June 2023

Abstract
To elucidate the mechanism of wood sandwich compression, the response of wood compressing yield stress to hygrothermal conditions was investigated in this study with respect to preheating temperature (30–210 °C) and moisture content (MC, 0–100 %). An associated functional model was developed to predict wood yield stress based on the measured MC and temperature in wood. A 1 % increase in wood MC or a 10 °C increase of temperature led to a decrease in wood yield stress exceeding 0.1 MPa. Significant variations in yield stress, exceeding 0.8 MPa, were observed between high MC layer(s) and the remaining layer(s) along the wood thickness when there was an MC variation over 5 %. Preheating the wood with by heating platens accelerated water/moisture migration in wood, resulting in relatively low yield stress in the wood interior areas where water/moisture had migrated. This study demonstrated that the comparatively low yield stress of some wood areas was responsible for sandwich compression. When mechanically compressed, only the wood layer(s) with lower yield stress was compressed, leading to sandwich compression, regardless of whether the mechanical force was applied tangentially or radially.
On weak commutativity in 𝑝-groups
Authors: Bastos Raimundo , de Melo Emerson , de Oliveira Ricardo , Monetta Carmine 
Published: June 2023

Abstract
The weak commutativity group

χ
⁢

(
G
)

\chi(G)

is generated by two isomorphic groups 𝐺 and

G
φ

G^{\varphi}

subject to the relations

[
g
,

g
φ

]

=
1

[g,g^{\varphi}]=1

for all

g
∈
G

g\in G

.
We present new bounds for the exponent of

χ
⁢

(
G
)

\chi(G)

and its sections, when 𝐺 is a finite 𝑝-group.
Seismic monitoring of strength in stabilized foundations by P-wave reflection and downhole geophysical logging for drill borehole core
Authors: Lindh Per , Lemenkova Polina 
Published: June 2023

Abstract
Evaluating the subground properties during the initial stage of a construction of building is important in order to estimate the suitability of soil quality to the technical requirements of bearing capacity, resistance to stress, and strength. This study presented the evaluation of the geotechnical properties of soil intended for the construction of Max IV facility of Lund University, performed in fieldwork and laboratory. The in situ methods included drilling boreholes, core sampling and assessment, crosshole measurements, and borehole logging. The laboratory-based measurements were performed at Swedish Geotechnical Institute and combined seismic measurements of drill cores, determination of the uniaxial compressive strength (UCS), and examination of material property: sieve analysis and natural moisture content. UCS was evaluated with regard to velocities of elastic P-waves. The synchronous light test by X-ray diffraction was performed for qualitative analysis of mineral composition of samples. The study applied integrated approach of the diverse geophysical methods to solve practical tasks on the evaluation of foundation strength and geotechnical parameters. This study demonstrated the benefits of integrated seismic and geophysical methods applied to soil exploration in civil engineering for testing quality of foundation materials.
Two-dimensional layered nanomaterials for tumor diagnosis and treatment
Authors: Hong Chengyuan , Liu Zhusheng , Chen Tianxiang , Wu Aiguo 
Published: June 2023

Abstract
With the evolution of nanomedicine, the past decades witnessed diversified nanomaterials as marvelous anti-tumor tools ushering in a new era of tumor diagnosis and treatment. Among them, two-dimensional layered nanomaterial as an emerging class of nanomaterials has one dimension less than 100 nm, showing a high specific area and the thinnest sheet-like structure (Liu S, Pan X, Liu H. Twodimensional nanomaterials for photothermal therapy. Angew Chem Int Ed 2020;59:5890–900). The discovery of graphene drove the exploration of various new two-dimensional layered nanomaterials for tumor diagnosis and treatment including graphene-based nanomaterials, black phosphorus (BP), transition metal dichalcogenides (TMDs), layered double hydroxides (LDHs), and bismuth oxyhalides (BiOX, X=F, Cl, Br, I) (Ma H, Xue MQ. Recent advances in the photothermal applications of two-dimensional nanomaterial: photothermal therapy and beyond. J Mater Chem 2021;9:17569). On the one hand, they exhibit strong near-infrared (NIR) absorption and the capacity of optimizing corresponding properties by adjusting the crystal structure. On the other hand, they own unique strengths such as fantastic physicochemical properties (graphene-based nanomaterials), high loading capacity (BP), distinct phase-dependent optical properties (TMDs), a specific chemical response to the tumor microenvironment (LDHs), and large X-ray attenuation coefficient (BiOX). Herein, we briefly introduce three typical two-dimensional layered nanomaterials, their prospects and future research priorities in tumor diagnosis and treatment are concluded.
The Size Distribution Measurement and Shape Quality Evaluation Method of Manufactured Aggregate Material Based on Deep Learning
Authors: Zang Bo , Peng Xiong , Zhong Xingu , Zhao Chao , Zhou Kun 
Published: June 2023

Abstract
Manufactured aggregate is a substitute for natural aggregate particles that is formed by mechanically crushing parent rock. Its particle shape has a great impact on the working performance, mechanical performance, and durability for preparing high-performance concrete. Therefore, a particle shape quality evaluation method combining deep learning and distance transformation topology is proposed. In this method, the YOLO v4 network is used to locate the particle region, and the centroid point is recognized as the feature point of this region; then, the feature points are used for distance transformation topology to approximately divide the particles area. Based on the divided results, the pixel-level segmentation result is obtained using a local threshold algorithm. The 2–8-mm limestone manufactured aggregate in a 2 million ton (1,000 kg)/year manufactured aggregate production line is carried out to demonstrate the effectiveness of the proposed method, achieving above 90 % precision in the real manufactured aggregate quality evaluation.
Effect of the Solder Powder Size of Sn-Bi-Ag-In Lead-Free Solder on the Wettability and Microstructure of Cu Substrate
Authors: Hu Tianhan , Li Zhen , Wu Guanzhi , Li Shun , Ding Kai , Gao Yulai 
Published: June 2023

Abstract
In this study, tin-bismuth-silver-indium (Sn-Bi-Ag-In) lead-free solder powders are prepared by the consumable-electrode direct current arc (CDCA) method. Without agglomeration, the satellite-free solder powders show good sphericity. The effect of solder powder sizes on the wettability and microstructure of Sn-Bi-Ag-In solder alloy on copper substrate is systematically investigated. The solder joints prepared by solder powder in a size of 53–120 μm exhibit relatively small wetting angles. In addition, the microstructure of the solder joints is composed of bismuth-rich phases, tin-rich phases, and Ag3Sn phases. A continuous intermetallic compound (IMC) layer with a thickness in the range of 0.64–0.70 μm is formed at the interface between the solder and the copper substrate. The results show that the formation and morphology variety of the IMC layers for different solder joints are unobvious, reflecting the good wettability of the Sn-Bi-Ag-In lead-free solder powders on the copper substrate in a wide size range.
Legal Instruments of Social Control in Swiss and Polish Self-Government: A Doctrinal and Legal Study
Authors: Salachna Joanna M. , Zawadzka-Pąk Urszula K. 
Published: June 2023

Abstract
One of the basic instruments of direct democracy is the referendum, which is particularly developed in Switzerland. In Poland, due to historical conditions, there is no tradition of using referendums; however, in recent years, the participation of citizens in public co-decision has started to be implemented through the instruments of governance (participatory democracy), i.e. the village council fund and participatory budgeting. Apart from the basic function, i.e. active participation in making public decisions, all the above-mentioned instruments should also fulfill another important role: it is social control in the financial sphere. Therefore, this study attempts to answer the following research question: do the instruments of direct and participatory democracy fulfil the function of social control in the field of public financial decisions, and if so, how? According to the adopted hypothesis, both the forms of direct and participatory democracy also constitute (contain) elements of social control of the activities of public authorities. And by their very nature, these legal instruments of social control are implemented in the form of ex ante external control. To verify this view, the study interprets the content of foreign and domestic acts of universally binding law (cantonal constitutions, statutory provisions).
Surgical techniques for the articular cartilage repair: literature review and meta-analysis
Authors: Burianov Oleksandr , Omelchenko Taras , Levytskyi Yevhenii 
Published: June 2023

Objective. To evaluate the clinical efficacy and safety of implementing the extracellular matrix (ECM), Autologous Matrix Induced Chondrogenesis (AMIC), adipose tissue derived mesenchymal stem cell (AD-MSCs), as well as bone marrow mesenchymal stem cells (BM-MSCs) for treating the osteochondral defects of knee joint and the talocrural one. Methods. Investigating by the facilities of PubMed, Embase and the manual searches, implemented from 2018 till January, 2022. There have been included articles with the І‒ІV level of evidence, studying the osteochondral defects over 0.5 сm2, with at least one-year duration of monitoring more than 10 patients, defining the scores on VAS (Visual Analogue Scale), Tegner Activity Scale, FAOS (Foot and Ankle Outcome Score). The results were evaluated after 1–2, 3–5 and over 5 years-period of monitoring. Meta-analysis was applied by the facilities of RStudio. Results. 14 investigations with 720 patients were incorporated. ECM, AMIC, AD-MSCs and BM-MSCs represented significantly better functional outcomes in comparison with the bone marrow stimulation procedures (MSP) on the VAS, Tegner Activity Scale, and FAOS scales. Patients treated according to the AMIC+BMAC (bone marrow aspirate concentrate) method showed better functional results compared to the standard AMIC technique. The rate of unsuccessful manipulations followed by revision operations in the MSP group is significantly higher than in others after 4 or more years of monitoring. The results obtained in a long-term investigation showed no deterioration after 5 years or more. Conclusions. Modern methods of cartilage repair in comparison with the creation of microfractures and microdrilling provide better quality regeneration, better long-term results, fewer complications, and higher rates of return to activity. Future studies should be longer-lasting and include more representative populations to determine the efficacy and safety of these methods.
Morphology of the repair of critical size bone defects which filling allogeneic bone implants in combination with mesenchymal stem cells depending on the recipient age in the experiment
Authors: Ashukina Nataliya , Vorontsov Petro , Maltseva Valentyna , Danуshchuk Zinaida , Nikolchenko Olga , Samoylova Kateryna , Husak Valeriia 
Published: June 2023

Mesenchymal stem cells (MSC) can be used to facilitate reparative osteogenesis. In the case of critical-size defects, MSC can attach to allogenic bone implants (AlloI) that serve as a matrix. Objective. Analyze the morphological features of reparative osteogenesis in critical-size defects in femurs of rats (3 and 12 months old) when the defects are filled with MSC along with AlloI. Methods. 60 white lab rats, 3 months (n=30) and 12 months (n=30) old were used. Defects (3mm in depth, 3mm in diameter) were created in the femoral metaphysis of each rat, and filled with AlloI in the control groups and with AlloI and adipose-derived MSC in the experimental groups. Each group contained 15 rats of a particular age. 14, 28, and 90 days after the surgery, histological studies were conducted. Results. The area of AlloI decreased with time. 14 days after the surgery, in the experimental group, the area of AlloI was 1.6 times greater in 3-month-old (3mo) rats than in 12-month-old (12mo) rats. In comparison to the control, the area of AlloI was greater 14 days after surgery in 3mo rats and 28 days after surgery in 12mo rats. 14 and 28 days after the operation, the area of connective tissue was greater in rats of both experimental groups than in the control. For the 3mo rats, the same was true 90 days after the operation. The area of newly formed bone was 1.6 times lower in 3mo rats than in 12mo rats 14 days after the operation. 90 days after the operation, the area was 2.3 greater in 3mo rats. For 12mo rats, the highest area of bone tissue occurred 14 days after the surgery, and subsequently did not significantly change or differ from the control. For 3mo rats, the area of bone tissue was lower than control 14 and 28 days after the surgery, but greater than control 90 days after the surgery. Conclusions. The use of MSC along with AlloI to fill traumatic bone defects causes slower bone formation and excessive formation of connective tissue, independent of the age of the recipient.
ЦИФРОВОЕ ИСКУССТВО И NFT: ПРАВОВАЯ НЕОПРЕДЕЛЕННОСТЬ
Authors: ГАЛЛЯМОВА Айсылу Айратовна 
Published: June 2023

Мы живем в эпоху цифровой трансформации. Многие ученые считают, что сегодня человечество переживает четвертую промышленную революцию. Первая произошла после открытия энергии пара, вторая — с внедрением конвейера, третья случилась благодаря созданию компьютера. Фундаментом четвертой стало возникновение цифровых технологий.
Цифровая трансформация привела к появлению качественно новых общественных благ, взаимодействие с которыми рождает новые правоотношения. Новые объекты данных отношений, в свою очередь, также нуждаются в правовом регулировании. Так, информационная трансформация повлияла на быстрый рост рынка цифровой интеллектуальной собственности, значительно увеличивая финансовые активы владельцев этих объектов. Однако такое стремительное появление различных объектов, созданных интеллектуальным трудом в цифровой среде, также способствовало различным злоупотреблениям и правонарушениям в связи с отсутствием четкого правового регулирования. Одним из таких быстро развивающихся объектов сегодня являются невзаимозаменяемые токены NFT. Первыми в использовании NFT выступили предприниматели творческой индустрии, которые стремились повысить свои доходы и найти новые способы взаимодействия с покупателями. Несмотря на быстрый рост популярности, были высказаны опасения по поводу законного владения активами NFT и распространению спекуляций и мошенничества, связанных с торговлей NFT.