bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ephemeral who? Evidence from the reconversion process implemented by Italian fashion companies in response to the COVID‐19 pandemic
Authors: Vecchi Alessandra , Colucci Mariachiara 
Published: March 2023

AbstractThe paper provides insights over the response of the Italian fashion companies to the pandemic between their willingness to help the country to face the emergency and their necessity to keep the business afloat. In an exploratory ethos and by relying on qualitative inductive research, the study investigates 11 fashion companies by also engaging in extensive secondary data collection at the industry level. By reconciling several theoretical lenses (i.e., strategic management, grand challenges and organizational ecology) into a systemic conceptual framework, the paper uncovers the underlying dynamics of the reconversion process by also unpacking the relevant dimensions that were leveraged by the companies to respond to the pandemic. Through the concept of adaptive resilience, the findings highlight how the Italian fashion companies were able to cope with the pandemic, with the reconversion process being implemented at the crossroads between exploring opportunities of a new (albeit often temporary) business and the exploitation of existing key resources and capabilities.
Modulation of bodily response to chill stimuli by impaired structural connectivity of the left insula: a functional and lesion quantification study in stroke patients
Authors: L. Witt , K. Klepzig , B. von Sarnowski , U. Horn , M. Domin , A. Hamm , M. Lotze 
Published: March 2023

AbstractBackground and purposeThe insula has important functions in monitoring and integrating physiological responses to a personal experience of multimodal input. The experience of chills in response to auditory stimuli is an important example for a relevant arousing experience coupled with bodily response. A group study about altered chill experiences in patients with insula lesions is lacking.MethodsTwenty‐eight stroke patients with predominantly insula lesions in the chronic stage and 14 age‐matched controls were investigated using chill stimuli of both valences (music, harsh sounds). Group differences were analyzed in subjective chill reports, associated bodily responses (skin conductance response), lesion mapping, diffusion‐weighted imaging and functional magnetic resonance imaging. Other neuropsychological deficits were excluded by comprehensive testing. Diffusion‐weighted imaging was quantified for four insula tracts using fractional anisotropy.ResultsThe frequency of chill experiences was comparable between participant groups. However, bodily responses were decreased for the stroke group. Whereas there was no association of lesion location, a positive association was found for the skin conductance response during aversive sounds and the tract connecting anterior inferior insula and left temporal pole in the stroke group. Similarly, functional magnetic resonance imaging activation in areas hypothesized to compensate for damage was increased with bodily response.ConclusionsA decoupling of felt arousal and bodily response after insula lesion was observed. Impaired bodily response was related to an impaired interaction of the left anterior insula and the temporal pole.
Multi‐feature gait analysis approach using deep learning in constraint‐free environment
Authors: Sethi Dimple , Prakash Chandra , Bharti Sourabh 
Published: March 2023

AbstractA quantitative gait assessment system is crucial for clinical analysis and decision‐making. Such rigorous evaluation involves costly clinical setups and domain experts for observation and analysis. To circumvent such constraints, the proposed work is conducted in a markerless environment and divided into three stages: First, we prepared a markerless gait database using videos from MNIT RAMAN LABORATORY in Jaipur. Second, we adapt the skeletal landmark data to generate kinematic gait characteristics comparable to gold‐standard marker‐based techniques. We provide a novel set of parameters based on video sequences and spatiotemporal and sagittal kinematic parameters to optimize accuracy and reliability. Third, we develop multi‐feature based gait analysis, an ensemble model based on Convolutional Neural Networks + LSTM (Long‐Short Term Memory), for gait classification. In addition, we deployed transfer learning models to correlate with our ensemble model. The findings indicate that gait analysis can be used successfully in a low‐cost clinical gait monitoring system in a constraint‐free environment. While considering the multiple gait variables, our proposed model attained an accuracy of 95.3%. Our model for quantifying gait analysis will improve access to quantitative gait analysis in clinics and rehabilitation centers and enable researchers to conduct large‐scale studies for gait‐related disorders.
The importance of frailty assessment in multiple myeloma: a position statement from the Myeloma Scientific Advisory Group to Myeloma Australia
Authors: Sim Shirlene , Kalff Anna , Tuch Gina , Mollee Peter , Ho P. Joy , Harrison Simon , Gibbs Simon , Prince H. Miles , Spencer Andrew , Joshua Douglas , Lee Cindy , Ling Silvia , Murphy Nick , Szabo Ferenc , Szer Jeff , Weber Nicholas , Ward Christopher , Talaulikar Dipti , Zannettino Andrew , Quach Hang 
Published: March 2023

AbstractMultiple myeloma (MM) is a disease of older people, yet factors relating to comorbidity and frailty may threaten treatment tolerability for many of this heterogenous group. There has been increasing interest in defining specific and clinically relevant frailty assessment tools within the MM population, with the goal of using these frailty scores, not just as a prognostic instrument, but also as a predictive tool to allow for a frailty‐adapted treatment approach. This paper reviews the various frailty assessment frameworks used in the evaluation of patients with MM, including the International Myeloma Working Group Frailty Index (IMWG‐FI), the Mayo Frailty Index and the simplified frailty scale. While the IMWG‐FI remains the most widely accepted tool, the simplified frailty scale is the most user‐friendly in busy day‐to‐day clinics based on its ease of use. This paper summarises the recommendations from the Myeloma Scientific Advisory Group (MSAG) of Myeloma Australia, on the use of frailty assessment tools in clinical practice and proposes a frailty‐stratified treatment algorithm to aid clinicians in tailoring therapy for this highly heterogeneous patient population.
RETRACTED: Wound dehiscence in enhanced recovery after open radical cystectomy: A meta‐analysis
Authors: Xue Guojun , Liu Yunbo , Ji Xuhui , Zhang Haiyun 
Published: March 2023

AbstractA meta‐analysis study to assess the outcome of enhanced recovery (ER) after radical cystectomy (RC) on wound dehiscence was performed. A comprehensive literature examination till January 2023 was implemented and 1457 linked studies were appraised. The picked studies contained 772 open RC subjects in the picked studies' baseline, 436 of them were enhanced recovery after RC, and 336 were open RC. Odds ratio (OR) in addition to 95% confidence intervals (CIs) were used to calculate the consequence of enhanced recovery after RC on wound dehiscence after open RC by the dichotomous styles and a fixed or random model. The ER after RC caused significantly lower wound dehiscence (OR, 0.51; 95% CI, 0.30–0.89, P = .02) with low heterogeneity (I2 = 46%) compared with open RC. The ER after RC caused significantly lower wound dehiscence compared with open RC. Thorough precaution should be taken when commerce with the consequences because a limited number of studies were found and selected for this meta‐analysis.
Genetic diversity of Toll‐like receptor 9 in swamp eels (Monopterus albus)
Authors: Huo Caifei , Tian Haifeng , Rao Han , Zeng Bo , Li Debing , Li Zhong , Li Yan 
Published: March 2023

AbstractThe swamp eel, Monopterus albus, is an important aquaculture species in Asia (mainly China) whose production has seriously suffered from infectious diseases. In spite of the critical requirement for aquaculture practices, to date there is scant information on its immune defence. Here, the genetic characteristics of Toll‐like receptor 9 (TLR9), which plays crucial roles in the initiation of host defence against microbial invasion, were analysed. It exhibits a striking lack of genetic variation resulting from a recent demographic bottleneck. A comparison with the homologue of M. javanensis revealed that replacement but not silent differences have nonrandomly accumulated in the coding sequences at the early stage following their split from a common ancestor. Furthermore, the replacements relevant to the type II functional divergence have mainly occurred in structural motifs mediating ligand recognition and receptor homodimerization. These results provide hints to understand the diversity‐based strategy of TLR9 in the arms race against pathogens. Furthermore, the findings reported here give credence to the importance of basic immunology knowledge, especially for the key elements, in genetic engineering and breeding for disease resistance in the eel and other fishes.
Comparing otolith shape descriptors for population structure inferences in a small pelagic fish, the European sardineSardina pilchardus(Walbaum, 1792)
Authors: Neves João , Veríssimo Ana , Múrias Santos António , Garrido Susana 
Published: March 2023

AbstractOtolith shape analysis has been one of the most used approaches to study population structure in the past decades. Currently, two sets of shape descriptors are used to perform otolith shape analysis, namely, Elliptic Fourier descriptor (EFd), which focuses on the overall otolith shape differences, and Discrete Wavelet descriptor (DWd), which is sensible to local differences along the otolith contour. Here, the authors conducted a comparative analysis of the performance of both the descriptors in reconstructing the population structure and connectivity patterns in a small pelagic fish species with a wide geographical distribution and fast growth rate, the European sardineSardina pilchardus(Walbaum, 1792), for the first time. A combination of each otolith shape descriptor and shape indices was explored using multivariate statistical methods. The two otolith shape descriptors showed similar, although limited, overall classification success associated with the population dynamic characteristics of the species. Both descriptors point to migration among adjacent areas, such as northern Atlantic locations, eastern Mediterranean and even across well‐defined physical obstacles, such as the Strait of Gibraltar, among Atlantic and western Mediterranean locations. Both descriptors supported the division of the populations of Mediterranean waters into three main groups but slightly differed in the group limits of the Atlantic waters. A comparison of the present results with those from previous otolith shape analysis studies using EFd on a decadal time scale revealed differences in the population structure and connectivity patterns compared to the earlier period. These differences not only may be attributed to changes in environmental variables leading to changes in population dynamics but can also be the result of the sardine biomass sharp decrease that occurred in the past decade.
Serum leucine‐rich alpha‐2 glycoprotein and calprotectin in children with inflammatory bowel disease: A multicenter study in Japan
Authors: Yasuda Ryosuke , Arai Katsuhiro , Kudo Takahiro , Nambu Ryusuke , Aomatsu Tomoki , Abe Naoki , Kakiuchi Toshihiko , Hashimoto Kunio , Sogo Tsuyoshi , Takahashi Michiko , Etani Yuri , Kato Ken , Yamashita Yushiro , Mitsuyama Keiichi , Mizuochi Tatsuki 
Published: March 2023

AbstractBackground and AimSerum leucine‐rich alpha‐2 glycoprotein (LRG) and calprotectin have been studied as disease activity markers in adults with inflammatory bowel disease (IBD). We evaluated them in pediatric IBD patients.MethodsSubjects under 17 years old undergoing care at 11 Japanese pediatric centers were retrospectively assigned to 3 groups representing Crohn's disease (CD), ulcerative colitis (UC), and normal controls (NC) with irritable bowel syndrome or no illness. Serum LRG and calprotectin were measured using commercial enzyme‐linked immunosorbent assay kits.ResultsWe enrolled 173 subjects, including 74 with CD, 77 with UC, and 22 NC. Serum LRG concentrations in active CD (median, 200 μg/mL) were significantly greater than in remission (81 μg/mL; P < 0.001) or NC (69 μg/mL; P < 0.001). Serum calprotectin concentrations in active CD (2941 ng/mL) also were significantly greater than in remission (962 ng/mL; P < 0.05) or NC (872 ng/mL; P < 0.05). Serum LRG concentrations in active UC (134 μg/mL) were significantly greater than in remission (65 μg/mL; P < 0.01) but not significantly greater than in NC (69 μg/mL); serum calprotectin concentrations in active UC (1058 ng/mL) were not significantly different from those in remission (671 ng/mL) or NC (872 ng/mL). In receiver operating characteristic analyses of LRG, calprotectin, C‐reactive protein, and erythrocyte sedimentation rate for ability to distinguish active IBD from remission, CD and UC showed areas under receiver operating characteristic curves for LRG (0.77 and 0.70, respectively), exceeding those for calprotectin, C‐reactive protein, or erythrocyte sedimentation rate.ConclusionsIn pediatric IBD, serum LRG may better reflect disease activity than serum calprotectin, particularly in CD.
The dynamic and iterative pre‐dispute phase: the transformation from a justiciable problem into a legal dispute
Authors: OLESEN ANNETTE , HAMMERSLEV OLE 
Published: March 2023

AbstractThe pre‐dispute phase, during which justiciable problems may or may not emerge and transform into legal cases, is complex. Based on a meta‐ethnography of 572 articles, all of which apply or refer to Felstiner et al.’s pioneering linear framework of naming, blaming, and claiming, we analysed the many sorting mechanisms that are at play in the pre‐dispute phase. We identified the institutional, political, cultural, and legal environments of various action arenas and the involvement of negotiating audiences as particularly important elements. Moreover, we found that the injured party's experiences and handling of a justiciable problem do not necessarily follow a predetermined chronology. Rather, we suggest that the process is dynamic and iterative, where the justiciable problem is repeatedly (re)named, (re)blamed, and (re)claimed, before it transforms into a legal case, develops in an alternative direction, or remains unchanged.
Combined Alport syndrome, Klinefelter syndrome and Fanconi syndrome in a Chinese boy
Authors: Zhang Hongwen , Wang Fang , Xiao Huijie 
Published: March 2023

AbstractAlport syndrome (AS) is a progressive renal disease characterized by hematuria and progressive renal failure. X‐linked dominant (XLAS) is the major inheritance form, accounting for almost 80% of the cases, caused by mutations in COL4A5 genes. Klinefelter syndrome (KS) is the most common genetic cause of human male gonadal dysgenesis. AS and KS are both rare disease, there are only three cases of combined AS and KS in the literatures. Fanconi syndrome (FS) caused by AS is also very rare. We report here the first case combined AS, KS and FS in a Chinese boy. We suggest that the severe renal phenotype and FS might be due to the two homozygous COL4A5 variants in our boy, and cases of AS combined KS will be good research objects for X chromosome inactivation.
Association between relative peripheral refraction and corresponding electro‐retinal signals
Authors: Gupta Satish Kumar , Chakraborty Ranjay , Verkicharla Pavan Kumar 
Published: March 2023

AbstractPurposeConsidering the potential role of the peripheral retina in refractive development and given that peripheral refraction varies significantly with increasing eccentricity from the fovea, we investigated the association between relative peripheral refraction (RPR) and corresponding relative peripheral multifocal electroretinogram (mfERG) responses (electro‐retinal signals) from the central to the peripheral retina in young adults.MethodsCentral and peripheral refraction using an open‐field autorefractor and mfERG responses using an electrophysiology stimulator were recorded from the right eyes of 17 non‐myopes and 24 myopes aged 20–27 years. The relative mfERG N1, P1 and N2 components (amplitude density and implicit time) of a mfERG waveform were compared with the corresponding RPR measurements at the best‐matched eccentricities along the principal meridians, that is at the fovea (0°), horizontal (±5°, ±10° and ± 25°) and vertical meridians (±10° and ± 15°).ResultsThe mean absolute mfERG N1, P1 and N2 amplitude densities (nV/deg2) were maximum at the fovea in both non‐myopes (N1: 57.29 ± 14.70 nV/deg2, P1: 106.29 ± 24.46 nV/deg2, N2: 116.41 ± 27.96 nV/deg2) and myopes (N1: 56.25 ± 15.79 nV/deg2, P1: 100.79 ± 30.81 nV/deg2, N2: 105.75 ± 37.91 nV/deg2), which significantly reduced with increasing retinal eccentricity (p < 0.01). No significant association was reported between the RPR and corresponding relative mfERG amplitudes at each retinal eccentricity (overall Pearson's correlation, r = −0.25 to 0.26, p ≥ 0.09). In addition, the presence of relative peripheral myopia or hyperopia at extreme peripheral retinal eccentricities did not differentially influence the corresponding relative peripheral mfERG amplitudes (p ≥ 0.24).ConclusionsRelative peripheral mfERG signals are not associated with corresponding RPR in young adults. It is plausible that the electro‐retinal signals may respond to the presence of absolute hyperopia (and not relative peripheral hyperopia), which requires further investigation.
Dual use of breeding stallions is possible without affecting the sperm quality
Authors: Hensel Britta , Jakop Ulrike , Schmicke Marion , Schröter Filip , Jung Markus , Schulze Martin 
Published: March 2023

AbstractArtificial insemination (AI) is commonly used in the equine industry to enhance the genetic value in breeding programs and to effectively utilize ejaculates. Many stallions are used as breeding stallions as well as in high‐level sports competitions to improve their market value. The goal of the present study was to investigate whether this dual use of stallions influences the animals´ stress levels and/or the quality of their ejaculates. For this purpose, 18 stallions were grouped into two categories: breeding stallions with (BSC = breeding stallion competition), and breeding stallions without secondary use in competitions (BS = breeding stallion). Two ejaculates were collected at a one‐week interval and analysed with an extended spectrum of spermatological methods. Furthermore, saliva, as well as seminal plasma samples were taken, and the concentration of cortisol therein was determined. Additionally, dehydroepiandrosterone (DHEA) and the cortisol/DHEA ratio were analysed and calculated for seminal plasma. After statistical analysis of the correlations and interdependences between the two groups, the results showed that the BSC group had significantly higher saliva cortisol levels (p = .027) and tendentially higher DHEA concentrations in their seminal plasma (p = .056). No difference between BS and BSC could be found in regard to the sperm quality parameters and the cortisol concentration in seminal plasma samples. It can be concluded that while active participation in competitions represents a stress factor, the dual use of stallions in breeding programs and sports competitions is possible without negative effects on their sperm quality.
Orexin system in buffalo ovarian follicles and effect of orexin on oestradiol production
Authors: Sardar Vikas M. , Gupta Mahesh , Korde Jayant P. , Bahiram Krushna B. , Bonde Sachin W. 
Published: March 2023

AbstractOrexin is a ligand for orexin receptors OX1R and OX2R; it is a neuropeptide with pleiotropic functions, including regulation of reproduction. The current study was carried out to investigate the mRNA expression of the prepro‐orexin gene (PPO) and orexin receptors (OX1R and OX2R) in ovarian follicles during different stages of their development in the ovary of water buffalo (Bubalus bubalis) and to determine the role of orexin on oestradiol production. Ovarian follicles were classified into four groups based on size and oestradiol (E2) level in the follicular fluid (FF) as follows: (i) small or F1, (ii) medium or F2, (iii) large or F3, and (iv) dominant/pre‐ovulatory follicle or F4. In follicles, the mRNA expression of PPO and OX1R was greater in F3 and F4 follicles in granulosa cells (GC) and theca interna (TI) cells. OX2R expression did not vary among the different follicular stages in GC. Orexin‐A and orexin receptors were localized in the cytoplasm of GC and TI, and intensity was higher in F3 and F4 follicles. In addition, we cultured GC and treated them at 0.1, 1.0, and 10 ng/mL orexin‐A alone or in the presence of FSH (30 ng/mL) or IGF‐I (10 ng/mL) for 48 h. There was a significant (p < .05) increase in oestradiol (E2) secretion and cytochrome P0450 family 19 subfamily A member 1 (CYP19A1) expression from GC at 1.0 and 10.0 ng/mL orexin‐A in the presence of 30 ng/mL follicle‐stimulating hormone (FSH) or 10 ng/mL insulin‐like growth factor‐I (IGF‐I). In conclusion, the present study provided evidence that the orexin system is expressed in buffalo ovarian follicles, and orexin‐A in the presence of FSH and IGF‐I has a stimulatory effect on oestradiol secretion from the GC of water buffalo.
Pelvic limb anesthesia and analgesia in dogs undergoing tibial plateau leveling osteotomy (TPLO): A survey of board‐certified anesthesiologists
Authors: Parker Lindsay A. , Bukoski Alex D. , Zelaya‐Nunez Cristopher , Dodam John R. , Varner Kelley M. , Torres Bryan T. 
Published: March 2023

AbstractObjectiveTo report the locoregional anesthesia and analgesia preferences of veterinary anesthesiologists for use in dogs undergoing a TPLO and determine any association with specialty college, time from board‐certification, or employment sector.Study designCross sectional study.Sample populationDiplomates of the American (ACVAA) and European (ECVAA) Colleges of Veterinary Anesthesia and Analgesia.MethodsAn electronic survey was distributed to diplomates and responses were used to determine associations between preferred methods.ResultsThe survey response rate was 28% (141/500) with 69% (97/141) of ACVAA diplomates and 31% of diplomates with ECVAA (44/141) certification. Peripheral nerve block (PNB) was preferred by 79% (111/141) of all diplomates, lumbosacral epidural (LE) by 21% (29/141), and peri‐incisional infiltration (PI) by <1% (1/141). There was no association (p = .283) with specialty college. There was an association (p < .001) with time from board‐certification with increased preference for LE when >10‐years from certification and PI preferred by only those board‐certified >20‐years ago. There was an association with employment sector (p = .003) with more academic diplomates preferring LE. Anesthesiologists reported that treatment decisions were affected by various factors including time pressure and surgeon influence.ConclusionDiplomates of ACVAA and ECVAA prefer PNB as the locoregional method of pelvic limb anesthesia in dogs undergoing TPLO. A greater percentage of newer and private practice diplomates prefer PNB while a larger percentage of senior and academic diplomates prefer LE. Decision making is multifactorial and includes perceived time pressure and surgeon influence.Clinical significanceVeterinary anesthesiologists prefer and frequently use PNB in dogs undergoing TPLO and surgeon influence may affect their chosen treatment.