bluuebunny/crossref_metadata_2025_split huggingface dataset:
From bedside to bench: how existing therapies inform the relationship between Epstein–Barr virus and multiple sclerosis
Authors: Dyer Zoe , Tscharke David , Sutton Ian , Massey Jennifer 
Published: February 2023

AbstractTherapy for relapsing–remitting multiple sclerosis (MS) has advanced dramatically despite incomplete understanding of the cause of the condition. Current treatment involves inducing broad effects on immune cell populations with consequent off‐target side effects, and no treatment can completely prevent disability progression. Further therapeutic advancement will require a better understanding of the pathobiology of MS. Interest in the role of Epstein–Barr virus (EBV) in multiple sclerosis has intensified based on strong epidemiological evidence of an association between EBV seroprevalence and MS. Hypotheses proposed to explain the biological relationship between EBV and MS include molecular mimicry, EBV immortalised autoreactive B cells and infection of glial cells by EBV. Examining the interaction between EBV and immunotherapies that have demonstrated efficacy in MS offers clues to the validity of these hypotheses. The efficacy of B cell depleting therapies could be consistent with a hypothesis that EBV‐infected B cells drive MS; however, loss of T cell control of B cells does not exacerbate MS. A number of MS therapies invoke change in EBV‐specific T cell populations, but pathogenic EBV‐specific T cells with cross‐reactivity to CNS antigen have not been identified. Immune reconstitution therapies induce EBV viraemia and expansion of EBV‐specific T cell clones, but this does not correlate with relapse. Much remains unknown regarding the role of EBV in MS pathogenesis. We discuss future translational research that could fill important knowledge gaps.
Low 25 (OH) vitamin D levels are associated with increased prevalence of nonalcoholic fatty liver disease and significant liver fibrosis
Authors: Ciardullo Stefano , Muraca Emanuele , Cannistraci Rosa , Perra Silvia , Lattuada Guido , Perseghin Gianluca 
Published: February 2023

AbstractAimsEvidence on the role of 25‐Hydroxyvitamin D (25(OH)D) in the occurrence and progression of nonalcoholic fatty liver disease (NAFLD) is conflicting and population‐based data are scarce. Here, we assess the association between 25(OH)D levels, NAFLD and liver fibrosis in the general population.Materials and MethodsThis is an analysis of data from the 2017–2018 cycle of the National Health and Nutrition Examination Survey. We included adult participants with available data on vibration‐controlled transient elastography (VCTE) and without viral hepatitis and significant alcohol consumption. Steatosis and fibrosis were diagnosed by the median values of controlled attenuation parameter (CAP) and liver stiffness measurement (LSM), respectively. 25(OH)D was measured by high performance liquid chromatography‐tandem mass spectrometry.ResultsA total of 3970 participants (1928 men and 2042 women) were included in the study. The prevalence of NAFLD (CAP ≥ 274 dB/m) and significant liver fibrosis (LSM ≥ 8 kPa) were 41.7% (95% CI 39.4–44.0) and 8.4% (95% CI 7.0–9.9), respectively, while 21.1% (95% CI 17.3–25.4) of participants had low 25(OH)D levels (<50 nmol/L). A multivariable logistic regression model adjusted for age, sex, race‐ethnicity, body mass index, waist circumference, calendar period, diabetes, chronic kidney disease, and vitamin D supplementation showed that compared with participants with low 25(OH)D, those with optimal levels (≥75 nmol/L) had lower odds of both NAFLD (OR 0.73, 95% CI 0.55–0.98 p = 0.038) and significant liver fibrosis (OR 0.65, 95% CI 0.44–0.96, p = 0.033).ConclusionsAn inverse relationship was found between 25(OH)D and NAFLD and fibrosis, suggesting a possible role of vitamin D in NAFLD occurrence and progression.
Taurodeoxycholate, a GPCR19 agonist, ameliorates atopic dermatitis in Balb/c mice
Authors: Ghaderpour Aziz , Jeong Ju‐Young , Kim Youn‐Hee , Zou Yunyun , Park Kyung‐Sun , Hong Eun‐Ji , Koh Young‐Jae , Seong Seung‐Yong 
Published: February 2023

AbstractKeratinocytes are pivotal cells in the pathogenesis of atopic dermatitis (AD) as much as Th2 cells. In this sense, regulation of pro‐inflammatory features of keratinocytes might be useful for AD patients. P2X7R‐mediated activation of NLRP3 inflammasome (N3I) in keratinocytes and myeloid cells plays crucial roles in AD. Nonetheless, inhibition of P2X7R has not been feasible because of polymorphisms and ubiquitous expression of P2X7R. Here, we report that GPCR19 colocalizes with P2X7R, and a GPCR19 agonist (taurodeoxycholate [TDCA]) inhibits the activation of P2X7R. Noncistronically, TDCA inhibits NF‐kB activation via the adenylate cyclase‐PKA pathway and BzATP‐mediated Ca++ mobilization. Cistronically, TDCA suppresses the expression of P2X7R and N3I components in keratinocytes. NLRP3 oligomerization and the production of mature IL‐1β and IL‐18 was suppressed by TDCA treatment in keratinocytes. Topical TDCA treatment ameliorates proinflammatory features of AD in mice induced by DNCB, MC903, or oxazolone. Taken together, a GPCR19 agonist such as TDCA might inhibit P2X7R‐mediated N3I activation of keratinocytes, which is crucial for the pathogenesis of AD.
Nitric Oxide Disproportionation Mediated by a Rh Complex with an Asymmetric Pincer Ligand: Spectroscopic Detection of a Dinitrosyl Intermediate
Authors: Gallego Cecilia M. , Ben‐David Yehoshoa , Milstein David , Doctorovich Fabio , Pellegrino Juan 
Published: February 2023

AbstractThe disproportionation of nitric oxide was studied by FTIR with two different Rh(I)PCN complexes as mediators (PCN 1‐((diethylamino)methyl)‐3‐((di‐tertbutylphosphino)methyl)‐benzene). As had already been reported for a PCP analogue, reaction yielded a Rh(PCN)(NO)(NO2) complex along with gaseous N2O in both cases. However, when [Rh(PCN)(NO)]⋅ was used as a reactant, FTIR monitoring allowed for the detection of signals of a reaction intermediate, coherent with the expected but seldom reported dinitrosyl species Rh(PCN)(NO)(NO). DFT studies on this species revealed that pincer hemilability of the amino arm is involved in its stabilization, therefore accounting for the differences observed in reactivity between PCN and PCP.
Coevolution mechanism and branch of pillar‐overburden fissures in shallow coal seam mining
Authors: Zhang Jie , He Yifeng , Yang Tao , Bai Wenyong , Wu Jianjun , Zhuo Qingsong , Gao Shoushi 
Published: February 2023

AbstractThe large‐scale mining of coal resources promotes the formation of section coal pillar groups between working faces. The overlying strata are supported by coal pillars, which leads to the formation of a unique fracture‐bearing structure in the key stratum, resulting in the evolution of fissures (cracks) and a generally high load on the supports. Studying the fracture‐bearing structure formed by coal pillars and overlying strata (fissures) is the basis for realizing rational mining of working faces. Here, the evolution characteristics of coal pillar‐overburden rock (fissures) in shallow coal seam mining and the working resistance of the support with stable fracture bearing structure of section coal pillar and overburden rock were studied in the No. 1‐2 coal mining of Longhua Coal Mine in Shenmu City, Northern Shaanxi. The fissure evolution characteristics on both sides of the coal pillar and the fracture‐bearing structure of the rock stratum were obtained by physical similarity simulation experiment. The mechanical calculation model of the coal pillar‐overburden rock (fissure) structure was established by theoretical derivation and calculation, and the working resistance of advanced support with a stable mechanical structure was studied. The research shows that the fracture evolution and rock fracture characteristics of a shallow coal seam mining face can be divided into three zones. Through the reanalysis of the mechanical structure of coal pillar‐overburden rock (fissure), the combined mechanical structure of the subkey stratum consisting of a lagging broken step rock beam structure and the main key stratum consisting of a hinged rock beam structure was obtained. Combined with the failure characteristics of the section coal pillar, a mechanical structure calculation method suitable for the bearing characteristics of section coal pillar support in shallow coal buried layers was obtained, and the field measurement results were verified.
Geostatistical and geoarchaeological study of Holocene floodplains and site distributions on the Sha‐Ying River Basin, Central China
Authors: Zhang Hai , Li Wei , Bevan Andrew , Wang Hui , Liang Fawei , Cao Yanpeng , Zhuang Yijie 
Published: February 2023

AbstractGeostatistics has become a powerful method for investigating complex spatial variations of prehistoric settlements in floodplains and other geomorphological settings. A geoarchaeological drilling program that covers most of the Sha‐Ying River Basin provides a rare opportunity with unusually detailed environmental data to contest and develop the geostatistics method, which proves to be essential, in combination with archaeological data, to understand long‐term (9000–2500 B.P.) patterns of human inhabitation and adaption to volatile floodplain environments in eastern Central China. We analysed the variography and multivariate ordination of the borehole data and explored the complexities of landform evolution, with reference to sedimentation processes and soil development in the floodplain of the Sha‐Ying River. The recurrent impact of river floods on regional landforms is manifested by spatial‐autocorrelated properties over distances up to 10 km, sometimes with directional trends. We then developed a model of landform evolution through kriging and compared the model with detailed reconstruction of archaeological settlement patterns. Our results illustrate long‐term socio‐environmental dynamics by which human communities first populated and then adapted in diverse ways to the changing floodplain environments from the early to middle Holocene. This improved method will have far‐reaching implications for future studies on similar geomorphological settings across vast floodplains of Central China and other global regions.
Predictive value of clinical and radiomic features for radiation therapy response in patients with lymph node‐positive head and neck cancer
Authors: Franzese Ciro , Lillo Sara , Cozzi Luca , Teriaca Maria Ausilia , Badalamenti Marco , Di Cristina Luciana , Vernier Veronica , Stefanini Sara , Dei Damiano , Pergolizzi Stefano , De Virgilio Armando , Mercante Giuseppe , Spriano Giuseppe , Mancosu Pietro , Tomatis Stefano , Scorsetti Marta 
Published: February 2023

AbstractBackgroundPrediction of survival and radiation therapy response is challenging in head and neck cancer with metastatic lymph nodes (LNs). Here we developed novel radiomics‐ and clinical‐based predictive models.MethodsVolumes of interest of LNs were employed for radiomic features extraction. Radiomic and clinical features were investigated for their predictive value relatively to locoregional failure (LRF), progression‐free survival (PFS), and overall survival (OS) and used to build multivariate models.ResultsHundred and six subjects were suitable for final analysis. Univariate analysis identified two radiomic features significantly predictive for LRF, and five radiomic features plus two clinical features significantly predictive for both PFS and OS. The area under the curve of receiver operating characteristic curve combining clinical and radiomic predictors for PFS and OS resulted 0.71 (95%CI: 0.60–0.83) and 0.77 (95%CI: 0.64–0.89).ConclusionsRadiomic and clinical features resulted to be independent predictive factors, but external independent validation is mandatory to support these findings.
Resistance from the margin: An autoethnographic account of academic ableism
Authors: Kwon Chang‐kyu 
Published: February 2023

AbstractAbleism—which refers to a socially‐sanctioned preference for normative bodies and minds, and which presumes one's abilities—is prevalent in any social system, including academia. However, despite an evolving disciplinary identity that seeks to improve work systems by addressing critical social issues, human resource development (HRD) as a field has done little to understand or advocate for the experiences of academics with disabilities. To challenge directly prevailing ableist assumptions and practices in academia, the present autoethnographic study was undertaken to reflect upon and detail my own experience of becoming an academic with a disability, specifically in the field of HRD. The story presented in this article presents evidence of unique challenges and opportunities facing an academic with a disability and seeks to stimulate meaningful dialogue around how to create a welcoming and inclusive academic culture for all. This article also advances autoethnography as a viable research methodology that allows for the authentic voices of members from marginalized communities and mobilizes change.
Multiple timescales of streambed flux variability in two perennial mountain‐front streams
Authors: Cognac Kristen E. , Ronayne Michael J. 
Published: February 2023

AbstractStreambed fluxes are highly variable through time and space, having a range implications for stream‐aquifer processes. This study investigated streambed fluxes over a 3‐year study period to characterize short‐ and long‐term variations and related implications for seepage recharge and hyporheic exchange. Time series of streambed fluxes were estimated through Darcy‐based methods using water level and temperature inputs from shallow (<1.5 m) nested streambed piezometers installed in two mountain‐front streams in Colorado, USA. Three predominant temporal scales of variability were characterized: sub‐daily (<1 day), daily (>1 day; <1 year), and interannual (>1 year). Temporal variability was quantified using the median absolute deviation (MAD), a statistical measure that is resistant to extreme values associated with short‐duration events. Sub‐daily variability (MADS‐D) was related to ET, temperature‐induced changes in hydraulic conductivity, and variable stream stage, and was quantified using the MAD of detrended fluxes (daily mean subtracted). Daily variability (MADD), calculated as the MAD of daily median fluxes for a given year, exceeded sub‐daily variability, and was influenced by strong seasonality at some sites. For individual sites and water years, the ratio of MADS‐D to MADD ranged from 0.03 to 0.70, with an average of 0.25. Annual median fluxes at each site varied across years, but typically remained consistent in order of magnitude and direction. Results reveal a strong linear correlation between the daily variability and the median annual flux at individual sites. Within a year, summer months characterized by stronger losing conditions showed greater overall variability. 1D numerical heat and flow modelling was performed to calibrate hydraulic parameters and to investigate temperature‐related controls for sub‐daily variations. We discuss implications of documented temporal variability for analyses of hyporheic exchange and groundwater recharge. Results provide a basis for quantifying temporal variations in streambed fluxes and highlight the extent to which fluxes vary over multiple timescales.
Reproductive outcomes after pre‐implantation genetic testing in heterozygous Robertsonian translocation carriers: A retrospective cohort study of 144 cycles
Authors: Jia Miaomiao , Xue Xia 
Published: February 2023

SynopsisThe purpose of this study was to evaluate meiotic segregation patterns and reproductive outcomes of pre‐implantation genetic testing (PGT) treatment in different types of RobT carriers.
RETRACTED: Whole‐body vibration versus supervised aerobic exercise on hormonal parameters and inflammatory status in women with premenstrual syndrome: A randomized controlled trial
Authors: Shehata Mai M.A. , Maged Ahmed M. , Kotb Amal , Ogila Asmaa I. , Lasheen Yossra , Salah Noha , Mohsen Reham A. , Fouad Mona , Abd‐Elazeim AlShaymaa S. 
Published: February 2023

AbstractObjectivesTo compare the effects of whole‐body vibration (WBV) and aerobic exercise on the hormonal profile and inflammatory status in women with premenstrual syndrome (PMS).MethodsA prospective, randomized, pre–post‐test, single‐blind, controlled trial was conducted in 105 women diagnosed with PMS. They were randomized into three equal groups. All women received magnesium and vitamin B complex supplementation once daily. WBV training was added three times per week to the WBV group. The aerobic exercise group added aerobic exercise three times per week, while the control group received no additional intervention. The Premenstrual Syndrome Questionnaire (PMSQ) was used to assess PMS symptoms. Blood analysis was performed to measure hormone assays (estradiol, progesterone, prolactin, and cortisol) and high‐sensitivity C‐reactive protein at the start and after the end of the treatment program.ResultsThere was no statistically significant difference between WBV and aerobic exercise according to PMSQ and high‐sensitivity C‐reactive protein (P = 0.99 and P = 0.98, respectively), but there was a statistically significant difference between both groups in cortisol, progesterone, prolactin, and estradiol (P = 0.001), with more favor given to the WBV group.ConclusionWBV and aerobic exercise have positive effects on women with PMS, with more favor given to WBV.
Mitochondrial–nuclear communication by FKBP51 shuttling
Authors: Zgajnar Nadia , Lagadari Mariana , Gallo Luciana I. , Piwien‐Pilipuk Graciela , Galigniana Mario D. 
Published: February 2023

AbstractThe HSP90‐binding immunophilin FKBP51 is a soluble protein that shows high homology and structural similarity with FKBP52. Both immunophilins are functionally divergent and often show antagonistic actions. They were first described in steroid receptor complexes, their exchange in the complex being the earliest known event in steroid receptor activation upon ligand binding. In addition to steroid‐related events, several pleiotropic actions of FKBP51 have emerged during the last years, ranging from cell differentiation and apoptosis to metabolic and psychiatric disorders. On the other hand, mitochondria play vital cellular roles in maintaining energy homeostasis, responding to stress conditions, and affecting cell cycle regulation, calcium signaling, redox homeostasis, and so forth. This is achieved by proteins that are encoded in both the nuclear genome and mitochondrial genes. This implies active nuclear‐mitochondrial communication to maintain cell homeostasis. Such communication involves factors that regulate nuclear and mitochondrial gene expression affecting the synthesis and recruitment of mitochondrial and nonmitochondrial proteins, and/or changes in the functional state of the mitochondria itself, which enable mitochondria to recover from stress. FKBP51 has emerged as a serious candidate to participate in these regulatory roles since it has been unexpectedly found in mitochondria showing antiapoptotic effects. Such localization involves the tetratricopeptide repeats domains of the immunophilin and not its intrinsic enzymatic activity of peptidylprolyl‐isomerase. Importantly, FKBP51 abandons the mitochondria and accumulates in the nucleus upon cell differentiation or during the onset of stress. Nuclear FKBP51 enhances the enzymatic activity of telomerase. The mitochondrial‐nuclear trafficking is reversible, and certain situations such as viral infections promote the opposite trafficking, that is, FKBP51 abandons the nucleus and accumulates in mitochondria. In this article, we review the latest findings related to the mitochondrial‐nuclear communication mediated by FKBP51 and speculate about the possible implications of this phenomenon.
Breaking free from a gang lifestyle: The use of a solution‐determined collaborative team to help transform a challenging and complex adolescent case situation
Authors: Selekman Matthew D. 
Published: February 2023

AbstractThis article presents the use of a solution‐determined collaborative team approach as an adjunct to family therapy with Jorge, a 14‐year‐old, with a long history of gang involvement, anger management difficulties, fighting with students and poor academic performance, verbally abusive towards some of his teachers and other school personnel, marijuana and alcohol abuse, and was diagnosed with Attention Deficit Hyperactivity Disorder. The use of solution‐determined collaborative teams can be the antidote for working with chronic and complex case situations with many helping professionals and concerned members from a family's social network involved and/or when conflicts are occurring between parents and school staff and with other larger systems professionals. The case example demonstrates the advantages of the concurrent use of a solution‐determined collaborative team comprised of as many of the involved helping professionals as possible and the family's identified key resource people from their social network, which combined with family therapy can help optimize for treatment success. In addition to discussing the mechanics of recruiting solution‐determined collaborative team members and the role of the hosting therapist, clinical situations where using this team approach is contraindicated are covered.
Determining factors in the overall happiness and outlook for the future of women living homeless: Evidence from Madrid, Spain
Authors: Cabrera Adrián , García‐Pérez Carmelo , Panadero Sonia , Vázquez José Juan 
Published: February 2023

AbstractPeople living homeless are quite heterogeneous groups, including different subgroups with specific characteristics that vary substantially. Within this group, women living homeless are an understudied subgroup with specific necessities which in most cases have not been addressed in general studies related to the group. The present study examines determining factors that influence the levels of overall happiness and outlook for the future of women living homeless. To fulfill this objective, a survey was conducted on a group of women living homeless in the city of Madrid (Spain). The results of a structural equation modeling analysis found that having a larger and stable social support network, loneliness, and good health conditions without any problems associated with drug abuse are the main factors influencing their levels of overall happiness and their outlook for the future. The proposed model has also shown that stressful life events play an important role in the analysis, unlike economic aspects, which have a limited impact on their situation. This article provides new information and innovation in research about homelessness, in particular women living homeless, thus being important for extending and replicating its findings to an international context.