bluuebunny/crossref_metadata_2025_split huggingface dataset:
PRESKRIPSI PENGELOLAAN HUTAN JATI RAKYAT DI KECAMATAN KAHU KABUPATEN BONE SULAWESI SELATAN
Authors: Molo Hasanuddin , Hikmah Hikmah , Sulfiana Sulfiana 
Published: March 2023

ABSTRACTThe purpose of this study was to determine the prescription of community teak forest management in Kahu District, Bone Regency, South Sulawesi Province. Data was collected includes primary data sourced from direct observations in the field, and respondents who are directly involved in the management of community teak forests. Data was collected through observation, interview and survey techniques and literature study. Analysis data was descriptively and quantitatively for the prescription of community teak forest management in Kahu District, Bone Regency. The results was showed that the prescription of community teak forest management applied by the community was still very simple, among others the cultivation system that was implemented only relied on natural seedlings as seed sources. Maintenance carried out in the form of cleaning weeds, pruning and maintenance of growing stubs. Harvesting is done by selecting and cutting down trees after a request from the buyer. The marketing system of teak wood production is divided into 2 ways, namely sales in the form of trees and sales in the form of bearings. The potential of community forests in Kahu Subdistrict of Bone Regency is quite large with an average total volume of 166.4 m³ / ha and a mean annual increment (MAI) of 17.8 m³ / ha / yearABSTRAK Tujuan Penelitian ini adalah untuk mengetahui preskripsi pengelolaan hutan jati rakyat di Kecamatan Kahu Kabupaten Bone, Provinis Sulawesi Selatan. Data yang dikumpulkan meliputi data primer bersumber dari hasil observasi langsung di lapangan, dan responden yang terlibat langsung dalam pengelolaan hutan jati rakyat. Data dikumpulkan melalui Teknik observasi ,wawancara dan survey serta studi pustaka. Analisis data dilakukan secara deskriptif dan kuantitatif untuk preskripsi pengelolaan hutan jati rakyat di Kecamatan Kahu Kabupaten Bone. Hasil penelitian menunjukkan bahwa preskripsi pengelolaan hutan jati rakyat yang diterapkan masyarakat masih sangat sederhana, antara lain sistem budidaya yang diterapkan hanya mengandalkan bibit anakan alami sebagai sumber bibit. Pemeliharaan yang dilakukan berupa pembersihan gulma, pemangkasan serta pemeliharaan trubusan yang sudah tumbuh. Pemungutan hasil hutan kayu yang dilakukan petani selama ini dengan cara memilih dan menebang pohon Ketika sudah ada kepastian pasar dan harga dari pembeli. Model pemasaran kayu jati yang selama ini dilkukan dengan cara menjual dalam bentuk tegakan berdiri maupun dalam bentuk log atau bantalan. Potensi volume pohon pda hutan rakyat yang ada di Kecamatan Kahu Kabupaten Bone cukup besar dengan volume total rata-rata yaitu 166,4 m³/ha dan riap tahunan/mean annual increment (MAI) 17,8 m³/ha/tahu
Kiusaamisen vastainen työ kouluissa
Authors: Sanna Herkama , Harjuniemi Inari , Repo Juuso , Valkiaranta Mona 
Published: March 2023

Kiusaamiseen pyritään usein tarttumaan koulussa toteuttavien interventio-ohjelmien avulla. Ohjelmien on tutkimuksissa havaittu vähentävän kiusaamista ja saavutettujen hyötyjen kasvavan, mitä pitempään ohjelmia toteutetaan. Samalla kuitenkin tiedetään, että osalla kouluista on haasteita kiusaamisen vastaisten ohjelmien ylläpitämisessä ja juurruttamisessa. Toistaiseksi ohjelmien toimeenpanoa ja siihen vaikuttavia tekijöitä on kuitenkin tutkittu melko vähän. Tämän tutkimuksen tavoitteena oli perehtyä tapaustutkimuksen keinoin siihen, miten kouluja tuetaan kiusaamisen vastaisten ohjelmien toimeenpanossa. Tutkimus nojasi laadukkaan toimeenpanon viitekehykseen, joka kuvaa erilaisia laadukasta toimeenpanoa tukevia askeleita. Menetelmänä oli välineellinen tapaustutkimus. Tarkasteltavaksi tapaukseksi valittiin suomalaisissa peruskouluissa yli kymmenen vuotta käytössä ollut KiVa Koulu -ohjelma. Arvioimme, millaisia mahdollisuuksia ja rajoituksia liittyy kouluille tarjottavaan mentorointiin sekä kartoituksiin ja kyselyihin laadukkaan ja pitkäkestoisen kiusaamisen vastaisen työn tukemisessa. Tuloksissa korostui mentoroinnin kohdalla mentorin mahdollisuus tukea pitkäkestoisesti kouluja omien käytänteiden kehittämisessä vuorovaikutuksessa mentoroitavien kanssa. Kyselyjen kohdalla tuloksissa painottuivat erilaiset hyödynnettävyyteen liittyvät näkökulmat. Tulokset tuottivat tietoa siitä, miten kouluja voitaisiin tukea jatkossa entistä vahvemmin kiusaamisen vastaisten ohjelmien toimeenpanossa.
Energy consumption performance using natural ventilation in dwelling design and CFD simulation in a hot dry climate: A case study in Sudan
Authors: Elhassan Zeinab A. 
Published: March 2023

Introduction: Sudan is taking proactive steps towards environmental sustainability, including initiatives to improve energy efficiency and reduce costs in a hot, dry climate. This article assesses the contribution of natural ventilation to heat transfer and temperature conditioning in urban areas in Khartoum, Sudan.Methods: The research methodology used a combination of building modeling with computational fluid dynamics (CFD) integrated with IESV Autodesk software to model natural ventilation and simulate energy consumption by incorporating natural ventilation into home design.Results: The best-case scenario for natural ventilation resulted in a 71.1% yearly energy savings. The design point of internal air speed was approximately 0.7 m/s, the point at which 95% of the indoor areas had an average air speed between 0.43 m/s and 0.9 m/s. The worst-case scenario occurred in the east/west direction, when 80% of the interior had an airflow between 0.05 m/s and 0.01 m/s; near open windows, the airflow was approximately 0.1 m/s.Discussion: This study was the first research in Khartoum on the design of clean and energy-saving sustainable architecture. The architectural design process for energy-efficient living in the urban region of Al-Azhari City was implemented and defined in a city quarter in Khartoum. The results showed that natural ventilation can maintain a comfortable indoor temperature in summer and significantly reduce energy costs. The findings may have implications for the design of sustainable buildings in other hot, dry climates.
Surface roughness modulates EGFR signaling and stemness of triple-negative breast cancer cells
Authors: Rosado-Galindo Heizel , Domenech Maribella 
Published: March 2023

Introduction: Cancer stem cells (CSC), a major culprit of drug-resistant phenotypes and tumor relapse, represent less than 2 % of the bulk of TNBC cells, making them difficult to isolate, study, and thus, limiting our understanding of the pathogenesis of the disease. Current methods for CSC enrichment, such as 3D spheroid culture, genetic modification, and stem cell conditioning, are time consuming, expensive, and unsuitable for high-throughput assays. One way to address these limitations is to use topographical stimuli to enhance CSC populations in planar culture. Physical cues in the breast tumor microenvironment can influence cell behavior through changes in the mechanical properties of the extracellular matrix (ECM). In this study, we used topographical cues on polystyrene films to investigate their effect on the proteome and stemness of standard TNBC cell lines.Methods: The topographical polystyrene-based array was generated using razor printing and polishing methods. Proteome data were analyzed and enriched bioprocesses were identified using R software. Stemness was assessed measuring CD44, CD24 and ALDH markers using flow cytometry, immunofluorescence, detection assays, and further validated with mammosphere assay. EGF/EGFR expression and activity was evaluated using enzyme-linked immunosorbent assay (ELISA), immunofluorescence and antibody membrane array. A dose-response assay was performed to further investigate the effect of surface topography on the sensitivity of cells to the EGFR inhibitor.Results: Surface roughness enriched the CSC population and modulated epidermal growth factor receptor (EGFR) signaling activity in TNBC cells. Enhanced proliferation of MDA-MB-468 cells in roughness correlated with upregulation of the epidermal growth factor (EGF) ligand, which in turn corresponded with a 3-fold increase in the expression of EGFR and a 42% increase in its phosphorylation compared to standard smooth culture surfaces. The results also demonstrated that phenotypic changes associated with topographical (roughness) stimuli significantly decreased the drug sensitivity to the EGFR inhibitor gefitinib. In addition, the proportion of CD44+/CD24−/ALDH+ was enhanced on surface roughness in both MDA-MB-231 and MDA-MB-468 cell lines. We also demonstrated that YAP/TAZ activation decreased in a roughness-dependent manner, confirming the mechanosensing effect of the topographies on the oncogenic activity of the cells.Discussion: Overall, this study demonstrates the potential of surface roughness as a culture strategy to influence oncogenic activity in TNBC cells and enrich CSC populations in planar cultures. Such a culture strategy may benefit high-throughput screening studies seeking to identify compounds with broader tumor efficacy.
Retinal fluid is associated with cytokines of aqueous humor in age-related macular degeneration using automatic 3-dimensional quantification
Authors: Song Siyuan , Jin Kai , Wang Shuai , Yang Ce , Zhou Jingxin , Chen Zhiqing , Ye Juan 
Published: March 2023

Background: To explain the biological role of cytokines in the eye and the possible role of cytokines in the pathogenesis of neovascular age-related macular degeneration (nAMD) by comparing the correlation between cytokine of aqueous humor concentration and optical coherence tomography (OCT) retinal fluid.Methods: Spectral-domain OCT (SD-OCT) images and aqueous humor samples were collected from 20 nAMD patient’s three clinical visits. Retinal fluid volume in OCT was automatically quantified using deep learning--Deeplabv3+. Eighteen cytokines were detected in aqueous humor using the Luminex technology. OCT fluid volume measurements were correlated with changes in aqueous humor cytokine levels using Pearson’s correlation coefficient (PCC).Results: The patients with intraretinal fluid (IRF) showed significantly lower levels of cytokines, such as C-X-C motif chemokine ligand 2 (CXCL2) (p = 0.03) and CXCL11 (p = 0.009), compared with the patients without IRF. And the IRF volume was negatively correlated with CXCL2 (r = −0.407, p = 0.048) and CXCL11 (r = −0.410, p = 0.046) concentration in the patients with IRF. Meanwhile, the subretinal fluid (SRF) volume was positively correlated with vascular endothelial growth factor (VEGF) concentration (r = 0.299, p = 0.027) and negatively correlated with interleukin (IL)-36β concentration (r = −0.295, p = 0.029) in the patients with SRF.Conclusion: Decreased level of VEGF was associated with decreased OCT-based retinal fluid volume in nAMD patients, while increased levels of CXCL2, CXCL11, and IL-36β were associated with decreased OCT-based retinal fluid volume in nAMD patients, which may suggest a role for inflammatory cytokines in retinal morphological changes and pathogenesis of nAMD patients.
Effects of Helicobacter pylori eradication on esophageal motility, esophageal acid exposure, and gastroesophageal reflux disease symptoms
Authors: Zhao Tong , Liu Fang , Li Yongjun 
Published: March 2023

BackgroundThe effects of Helicobacter pylori (HP) eradication on gastroesophageal reflux disease (GERD) are yet to be fully elucidated. Few studies have investigated the mechanisms underlying the correlations between HP and GERD with prospective methods. The objective of this prospective clinical study was to explore the effects of HP eradication on GERD.MethodsPatients diagnosed with both GERD and HP were included. High-resolution esophageal manometry (HRM), 24-h esophageal pH monitoring, and the Gastroesophageal Reflux Disease Questionnaire (GerdQ) were performed before and after the successful eradication of HP, and the data were compared using statistical analysis.ResultsSixty-eight patients diagnosed with both GERD and HP were included. The After HP eradication group showed significantly decreased median distal contractile integral (DCI) [610.40 (847.45) vs. 444.90 (559.60)] and significantly increased median inefficient esophageal motility (IEM) [36.00 (50.00) vs. 60.00 (57.00)] in the HRM compared with those of the Before HP eradication group, indicating that HP eradication reduced esophageal peristalsis. The 24-h esophageal pH monitoring showed that the longest reflux event, the percentage of time that the pH was &lt;4, the number of reflux episodes, and the DeMeester score were all significantly different between the Before and After HP eradication groups (P &lt; 0.05), suggesting that HP eradication increased esophageal acid exposure. The After HP eradication group also had a significantly higher GerdQ score than that of the Before HP eradication group (P &lt; 0.05).ConclusionsHP eradication reduced esophageal peristalsis, enhanced esophageal acid exposure, and aggravated GERD symptoms, suggesting that HP infection may be a protective factor for GERD.
Clinical characteristics and risk factors of cardiac surgery associated-acute kidney injury progressed to chronic kidney disease in adults: A retrospective, observational cohort study
Authors: Fan Xiaoguang , Shao Zehua , Gao Suhua , You Zhenzhen , Huo Shuai , Zhang Zhu , Li Qiuhong , Zhou Saijun , Yan Lei , Shao Fengmin , Yu Pei 
Published: March 2023

IntroductionTo retrospectively investigate the clinical characteristics and risk factors of cardiac surgery associated-acute kidney injury (CS-AKI) progressed to chronic kidney disease (CKD) in adults and to evaluate the performance of clinical risk factor model for predicting CS-AKI to CKD.MethodsIn this retrospective, observational cohort study, we included patients who were hospitalized for CS-AKI without a prior CKD [estimated glomerular filtration rate (eGFR) &lt; 60 ml · min−1·1.73 m−2] at Central China Fuwai Hospital from January 2018 to December 2020. Survived patients were followed up for 90 days, the endpoint was CS-AKI to CKD, and then divided them into two groups (with or without CS-AKI to CKD). The baseline data including demographics, comorbidities, renal function, and other laboratory parameters were compared between two groups. The logistic regression model was used to analyze the risk factors for CS-AKI to CKD. Finally, receiver operator characteristic (ROC) curve was drawn to evaluate the performance of the clinical risk factor model for predicting CS-AKI to CKD.ResultsWe included 564 patients with CS-AKI (414 males, 150 females; age: 57.55 ± 11.86 years); 108 (19.1%) patients progressed to new-onset CKD 90 days after CS-AKI. Patients with CS-AKI to CKD had a higher proportion of females, hypertension, diabetes, congestive heart failure, coronary heart disease, low baseline eGFR and hemoglobin level, higher serum creatinine level at discharge (P &lt; 0.05) than those without CS-AKI to CKD. Multivariate logistic regression analysis revealed that female sex(OR = 3.478, 95% CI: 1.844–6.559, P = 0.000), hypertension (OR = 1.835, 95% CI: 1.046–3.220, P = 0.034), coronary heart disease (OR = 1.779, 95% CI: 1.015–3.118, P = 0.044), congestive heart failure (OR = 1.908, 95% CI: 1.124–3.239, P = 0.017), preoperative low baseline eGFR (OR = 0.956, 95% CI: 0.938–0.975, P = 0.000), and higher serum creatinine level at discharge (OR = 1.109, 95% CI: 1.014–1.024, P = 0.000) were independent risk factors for CS-AKI to CKD. The clinical risk prediction model including female sex, hypertension, coronary heart disease, congestive heart failure, preoperative low baseline eGFR, and higher serum creatinine level at discharge produced a moderate performance for predicting CS-AKI to CKD (area under ROC curve = 0.859, 95% CI: 0.823–0.896).ConclusionPatients with CS-AKI are at high risk for new-onset CKD. Female sex, comorbidities, and eGFR can help identify patients with a high risk for CS-AKI to CKD.
Site formation process of the Dadong Paleolithic site in Jilin province, China: A geoarchaeological approach
Authors: Lian Huiru , Xu Ting , An Wenrong , Zhu Yujin , Shi Hongwei , Zhao Ying , Chen Kunlong 
Published: March 2023

The Dadong site, located in the Changbaishan region of Jilin province, China, is an important Upper Paleolithic site characterized by its large distribution area and abundant stone artifacts. This study presents a geoarchaeological study of a newly excavated area of this site. Soil micromorphology, particle size analysis, and pH measurements were used to reconstruct the site formation process from around 60 ka to the present. Additionally, this study examines the impact of volcanic eruptions and local geomorphology on ancient human adaptation in this area. This paper also investigates the effects of post-depositional processes, particularly freeze-thaw, on the distribution of lithics. This study is the first soil micromorphological study of a Paleolithic site in Northeast China, and is important for studying the changes of the Pleistocene environment in this region as well as the development of microblade technology in Northeast Asia.
Water resources optimal allocation model for coordinating regional multi-level water resources managers’ interests
Authors: Zhang Shiwei , Fang Guohua , Zhang Dasheng , Ju Maosen , Zhong Huayu 
Published: March 2023

In water resources management on a global scale, it is important to reconcile the conflicting interests of different regions and actors regarding water use. To solve this issue more effectively, an optimal allocation model of water resources that coordinates the interests of regional multi-level water resource managers and balances the benefits acquired by regional multi-level water resource managers was proposed. The model consisted of three components, including option generation, option selection, and fallback bargaining. The Hybrid Strategy Whale Optimization Algorithm (HSWOA) was created to generate the initial alternative set throughout the alternative generation process. In the alternative screening process, quick non-dominated sorting was used to choose Pareto alternatives from the initial alternative set. Through many rounds of negotiations, water resource managers at all levels reached a consensual water resource allocation plan during fallback bargaining. This model was used to reconcile the conflicting water interests of municipal and county water managers in Handan, China, in terms of economic, social, and ecological benefits. It was also compared with the Pareto solution set obtained from NSGA-III. In terms of convergence speed and accuracy, the results demonstrated that HSWOA outperformed the Whale Optimization Algorithm (WOA). The results show that several rounds of discussions between municipal and county water management eventually resulted in Nash equilibrium. In normal flow year, the recommended scheme could yield economic benefit of 315.08×108 Yuan, social benefit of 0.1700, and ecological benefit of 5.70 × 106 m3, whereas in low flow year, the recommended scheme could yield economic benefit of 354.85×108 Yuan, social benefit of 0.2103, and ecological benefit of 57.82 × 106 m3. Compared to existing studies, the recommended scheme has clear advantages in terms of social and ecological benefits. The proposed optimal water resource allocation was Pareto optimal. This paper presented a new way of thinking about reconciling the conflicting interests of different levels of water resource managers in the process of water allocation.
Enhancing landslide management with hyper-tuned machine learning and deep learning models: Predicting susceptibility and analyzing sensitivity and uncertainty
Authors: Dahim Mohammed , Alqadhi Saeed , Mallick Javed 
Published: March 2023

IntroductionNatural hazards such as landslides and floods have caused significant damage to properties, natural resources, and human lives. The increased anthropogenic activities in weak geological areas have led to a rise in the frequency of landslides, making landslide management an urgent task to minimize the negative impact. This study aimed to use hyper-tuned machine learning and deep learning algorithms to predict landslide susceptibility model (LSM) and provide sensitivity and uncertainty analysis in Aqabat Al-Sulbat Asir region of Saudi Arabia.MethodsRandom forest (RF) was used as the machine learning model, while deep neural network (DNN) was used as the deep learning model. The models were hyper-tuned using the grid search technique, and the best hypertuned models were used for predicting LSM. The generated models were validated using receiver operating characteristics (ROC), F1 and F2 scores, gini value, and precision and recall curve. The DNN based sensitivity and uncertainty analysis was conducted to analyze the influence and uncertainty of the parameters to the landslide.ResultsResults showed that the RF and DNN models predicted 35.1–41.32 and 15.14–16.2 km2 areas as high and very high landslide susceptibility zones, respectively. The area under the curve (AUC) of ROC curve showed that the LSM by the DNN model achieved 0.96 of AUC, while the LSM by RF model achieved 0.93 of AUC. The sensitivity analysis results showed that rainfall had the highest sensitivity to the landslide, followed by Topographic Wetness Index (TWI), curvature, slope, soil texture, and lineament density.DiscussionRoad density and geology map had the highest uncertainty to the landslide prediction. This study may be helpful to the authorities and stakeholders in proposing management plans for landslides by considering potential areas for landslide and sensitive parameters.
Geochemical factors associated with deposition of lower Aptian organic-rich sediments during OAE1a in the Basque-Cantabrian Basin, northern Spain
Authors: Herdocia Carlos , Maurrasse Florentin J-M. R. 
Published: March 2023

Introduction: The Early Aptian Oceanic Anoxic Event 1a (OAE1a) is characterized by organic matter (OM) bearing rocks identified worldwide, which also occur in the hemipelagic succession of the Cuchía section, North Basque-Cantabrian Basin (NBCB) in Northern Spain. Previous works identified OAE1a using δ13C calibrated with biostratigraphy of planktonic foraminifera, calcareous nannoplankton, and ammonites. However, the geochemical characteristics that controlled OM sources and the redox conditions during OAE1a are yet to be determined. Therefore, here we present the results of a high-resolution complementary study along 67 m of the succession at Playa de los Caballos beach that highlights how local factors in the basin modulated the effects of increased precipitation during enhanced global hydrological cycles.Methods: Samples were analyzed for total inorganic carbon (TIC), total organic carbon (TOC), δ13C, major elements (Al, Ti, Si), redox sensitive trace elements (RSTEs), clay mineralogy, bulk mineralogy, and biomarkers.Results and Discussion: Carbon isotope segments C2 to C6 were recognized to determine the age of the outcrop. Lipid biomarkers indicated that OM is predominantly marine with significant terrestrial contribution. Terrigenous OM was carried to the basin through pulses of fluvial input as attested by the major elements and by high relative proportions of quartz, feldspar, and clay minerals. Increased terrestrial inputs also enhanced primary production and facilitated OM preservation. Periods with hightened RSTE content correspond with increases in the major elements, thus implying their common provenance. High sedimentation rates together with the presence of less labile OM and the interaction with clay minerals most likely played a major role in preserving the OM. This study further highlights how enhanced hydrological cycles significantly influenced the marine conditions that controlled the expression of OAE1a in the NBCB.