bluuebunny/crossref_metadata_2025_split huggingface dataset:
Navigating Risk in the Modern Business Landscape: Strategies and Insights for Enterprise Risk Management Implementation
Authors: Olaniyi Oluwaseun Oladeji , Olabanji Samuel Oladiipo , Abalaka Anthony Idoko 
Published: September 2023

As businesses actively seek ways to safeguard their valuable data and resources, efficient defense techniques are paramount [1]. The surge in cyber threats, driven by malicious attacks and cybercrime fueled by internet technology and mobile apps, emphasizes the urgency for comprehensive risk management strategies [2]. Effective risk management strategies have become indispensable for competitive businesses [1]. ERM entangles determining, evaluating, and thwarting potential hazards that endanger business objectives [3].
Successful ERM implementation faces challenges like corporate culture, board knowledge, excessive risk lists, undefined timeframes, and engagement barriers [4]. Solutions include fostering transparency, improving board education, focusing on crucial risks, defining timeframes, and making ERM engaging for employees [4]. Key components of effective ERM include governance, strategy, performance assessment, communication, and information sharing [5]. For future research, exploring the integration of emerging technologies in ERM and studying the long-term impacts of successful ERM implementations holds promise [6]. A strong risk culture, defined roles, and transparent communication are essential for sustainable ERM success [7]. To thrive in a dynamic business landscape, organizations must build a robust risk culture that permeates every level of their operations [7].
A Chromatic Nanoswitcher for Thermal Monitoring of Cell Metabolism
Authors: Zhang Fengchan , París Ogáyar Marina , Artiga Álvaro , Hernando Jordi , Villar‐Álvarez Eva , Lorenzo Julia , Salegi Ansa Beñat , Cogliati Sara , Formentini Laura , Haro‐González Patricia , Ruiz‐Molina Daniel , Otaegui Jaume Ramon , Roscini Claudio , Jaque Daniel 
Published: January 2025

AbstractAccurate sensing of intracellular temperature is crucial for understanding and monitoring cell metabolism, serving as an initial step toward diagnosing conditions such as mitochondria‐related diseases. However, thermal monitoring of cell metabolism is challenging due to the minimal temperature variations caused by intracellular metabolic activity (typically ≈1 °C) and by the risk of crosstalk in intracellular sensors. A novel type of intracellular thermal sensor is presented, based on silica nanocapsules filled with a thermo‐responsive fluorescent medium. This medium undergoes a reversible phase transition from solid to liquid at temperatures ≈37 °C, inducing a chromatic switch that facilitates remote thermal sensing. The chromatic switchers exhibit a thermal sensitivity of ≈13% °C⁻¹ at 37 °C, one of the highest reported for intracellular thermal sensing. Notably, the thermal response is unaffected by external factors such as pH, ionic strength, and viscosity. Moreover, it is confirmed that the response of the sensors is not affected by the cellular activity, underscoring their reliability for cytoplasmic temperature measurements. The potential of these sensors is demonstrated by measuring intracellular heating during the metabolic switch from mitochondrial to glycolytic activity, showcasing their potential for real‐time, precise thermal monitoring (<1 °C) of cell metabolism.
Stress Relaxation for Lead Iodide Nucleation in Efficient Perovskite Solar Cells
Authors: Zheng Zhimiao , Ge Yansong , Yang Xiangfeng , Shao Wenlong , Wang Haibing , Yu Zixi , Tao Chen , Fu Huahua , Ke Weijun , Fang Guojia 
Published: January 2025

AbstractPorous lead iodide (PbI2) film is crucial for the complete reaction between PbI2 and ammonium salts in sequential‐deposition technology so as to achieve high crystallinity perovskite film. Herein, it is found that the tensile stress in tin (IV) oxide (SnO2) electron transport layer (ETL) is a key factor influencing the morphology and crystallization of PbI2 films. Focusing on this, lithium trifluoromethanesulfonate (LiOTf) is used as an interfacial modifier in the SnO2/PbI2 interface to decrease the tensile stress to reduce the necessary critical Gibbs free energy for PbI2 nuclei formation. The relaxed tensile stress facilitates the more porous PbI2 generation with larger particles and higher roughness, resulting in superior‐quality perovskite films. Besides, this strategy effectively passivates the inherent electron traps of SnO2 and smooths the interfacial energy levels, boosting the charge extraction and transfer. As a result, a champion power conversion efficiency (PCE) of 25.33% (25.10% stabilized for 600 s) is achieved. Furthermore, the device demonstrates exceptional stability, retaining 90% of its initial PCE at its maximum power point tracking measurement (under 100 mW cm−2 white light illumination at ≈55 °C temperature, in N2 atmosphere) after 600 h.
Targeting MAPK14 by Lobeline Upregulates Slurp1‐Mediated Inhibition of Alternative Activation of TAM and Retards Colorectal Cancer Growth
Authors: Zhao Mingxia , Zhou Lisha , Zhang Qinchang , Wang Meijing , Dong Yue , Wang Yue , Pei Ruixue , He Enguang , Liang Yanyan , Shen Yujun , Deng Guoliang , Chen Hongqi , Sun Dongdong , Shen Yuxian , Sun Yang , Cheng Haibo 
Published: January 2025

AbstractColorectal cancer (CRC) usually creates an immunosuppressive microenvironment, thereby hindering immunotherapy response. Effective treatment options remain elusive. Using scRNA‐seq analysis in a tumor‐bearing murine model, it is found that lobeline, an alkaloid from the herbal medicine lobelia, promotes polarization of tumor‐associated macrophages (TAMs) toward M1‐like TAMs while inhibiting their polarization toward M2‐like TAMs. Additionally, lobeline upregulates mRNA expression of secreted Ly‐6/UPAR‐related protein 1 (Slurp1) in cancer cells. The inhibitory effects of lobeline on tumor load and TAM polarization are almost completely eliminated when Slurp1‐deficient MC38 cells are subcutaneously injected into mice, suggesting that lobeline exerts an antitumor effect in a Slurp1‐dependent manner. Furthermore, using target‐responsive accessibility profiling, MAPK14 is identified as the direct target protein of lobeline. Mechanistically, upon binding to MAPK14 in colon cancer cells, lobeline prevents nuclear translocation of MAPK14, resulting in decreased levels of phosphorylated p53. Consequently, negative transcriptional regulation of SLURP1 by p53 is suppressed, leading to enhanced transcription and secretion of SLURP1. Finally, combination therapy using lobeline and anti‐PD1 exhibits stronger antitumor effects. Taken together, these findings suggest that remodeling the immunosuppressive microenvironment using small‐molecule lobeline may represent a promising therapeutic strategy for CRC.
Programmed Transformation of Osteogenesis Microenvironment by a Multifunctional Hydrogel to Enhance Repair of Infectious Bone Defects
Authors: Xie En , Yuan Zhangqin , Chen Qianglong , Hu Jie , Li Jiaying , Li Kexin , Wang Huan , Ma Jinjin , Meng Bin , Zhang Ruoxi , Mao Haijiao , Liang Ting , Wang Lijie , Liu Chaoyong , Li Bin , Han Fengxuan 
Published: January 2025

AbstractRepair of infectious bone defects remains a serious problem in clinical practice owing to the high risk of infection and excessive reactive oxygen species (ROS) during the early stage, and the residual bacteria and delayed Osseo integrated interface in the later stage, which jointly creates a complex and dynamic microenvironment and leads to bone non‐union. The melatonin carbon dots (MCDs) possess antibacterial and osteogenesis abilities, greatly simplifying the composition of a multifunctional material. Therefore, a multifunctional hydrogel containing MCDs (GH‐MCD) is developed to meet the multi‐stage and complex repair needs of infectious bone injury in this study. The GH‐MCD can intelligently release MCDs responding to the acidic microenvironment to scavenge intracellular ROS and exhibit good antibacterial activity by inducing the production of ROS in bacteria and inhibiting the expression of secA2. Moreover, it has high osteogenesis and long‐lasting antimicrobial activity during bone repair. RNA‐seq results reveal that the hydrogels promote the repair of infected bone healing by enhancing cellular resistance to bacteria, balancing osteogenesis and osteoclastogenesis, and regulating the immune microenvironment. In conclusion, the GH‐MCD can promote the repair of infectious bone defects through the programmed transformation of the microenvironment, providing a novel strategy for infectious bone defects.
“Popping the Ion‐Basket”: Enhancing Thermoelectric Performance of Conjugated Polymers by Blending with Latently Dissociable Perovskite Quantum Dots
Authors: Lee Hansol , Kim Hoimin , Jin Haedam , Kang Seungju , Yoon Tae Woong , Lee Dongki , Zhang Guobing , Kim Min , Kang Boseok 
Published: January 2025

AbstractA novel additive method to boost the Seebeck coefficient of doped conjugated polymers without a significant loss in electrical conductivity is demonstrated. Perovskite (CsPbBr3) quantum dots (QDs) passivated by ligands with long alkyl chains are mixed with a conjugated polymer in a solution phase to form polymer‐QD blend films. Solution sequential doping of the blend film with AuCl3 solution not only doped the conjugated polymer but also decomposed the QDs, resulting in a doped conjugated polymer film embedded with separated ions dissociated from the QDs. For the doped polymer‐molten QD blend films with the optimal QD content, it is found that a greatly enhanced Seebeck coefficient is achieved compared to that of the doped polymer film without QDs, while the doping level and electrical conductivity are not significantly reduced by the QD incorporation. Consequently, the power factor is enhanced, reaching a remarkably high value of up to 401.9 µW m−1 K−2 (≈155% increase with the QDs). The applicability of this method to a variety of conjugated polymers is also demonstrated. The enhancement in the Seebeck coefficient is attributed to ion‐induced local variations in the polymer work function, which generates an internal energy barrier for charge transport and causes an energy filtering effect.
Extreme Tolerance of Nanoparticle‐Protein Corona to Ultra‐High Abundance Proteins Enhances the Depth of Serum Proteomics
Authors: Liu Qiqi , Wang Mengjie , Dai Xin , Li Shuangqin , Guo Haoxiang , Huang Haozhe , Xie Yueli , Xu Chenlu , Liu Yuan , Tan Weihong 
Published: January 2025

AbstractThe serum nanoparticle‐protein corona (NPC) provides specific disease information, thus opening a new avenue for high‐throughput in‐depth proteomics to facilitate biomarker discovery. Yet, little is known about the interactions between NPs and proteins, and its role in enhanced depth of serum proteomics. Herein, a series of protein spike‐in experiments are conducted to systematically investigate protein depletion and enrichment during NPC formation. Proteomic depth is serum concentration‐dependent, and NPC exhibits powerful tolerance to ultra‐high abundant proteins. In addition, protein‐protein interactions (PPI), especially those involving albumin, play a pivotal role in promoting proteomic depth. Furthermore, a triple‐protein assay is established to interrogate the relationship between protein binding affinity and concentration. NPC formation is a product of balancing binding affinity, concentration, and PPI. Overall, this study elucidates how NPs achieve protein depletion and enrichment for enhanced serum proteomic depth to gain a better understanding of NPC as an essential tool of proteome profiling.
Gold‐Catalyzed Highly Regioselective Hydration of Alkynylsulfonamides for Atom‐Economic Synthesis of N‐Ketosulfonamides
Authors: Wang Yuguang , Ma Menghao , Deng Yunlong , Yao Panpan , Xing Agui , Li Wenjing , Chen Yuan , Wu Ji'an 
Published: January 2025

ABSTRACTGold(I)‐catalyzed highly regioselective hydration of alkynylsulfonamides for synthesis of N‐ketosulfonamides in 85%–96% yields. The reaction used water as a nucleophile, which had the advantages of mild reaction conditions, good functional group tolerance, high regioselectivity, high yield, and 100% atomic economy (without generating by‐products or waste). This might endow this method with great potential in green synthesis of N‐ketosulfonamides compounds.
Evaluating Electrospun Polycaprolactone Fibers for Blood‐Contacting Applications
Authors: Kuddushi Muzammil , Pawar Aishwarya S , Ghaffari Sharaf Mehdi , Unsworth Larry D. , Zhang Xuehua 
Published: January 2025

ABSTRACTWhen the kidneys are injured, uremic toxins (UTXs) accumulate in the body, affecting other tissues and causing a loss of essential body functions. This study investigated the adsorption of blood plasma‐laden UTXs on the surface of PCL fibers to assess their potential as an alternative to membrane dialysis materials. Using plasma containing 26 UTXs at a concentration similar to that found in end‐stage kidney disease patients, we analyzed the adsorbed proteins and examined clot formation in normal and toxin‐treated plasma in the presence of PCL fibers. Our findings revealed that the presence of UTXs significantly increased the adsorption of proteins on PCL fiber meshes, without leading to increased clot formation. This suggests a lack of enzymatic activation despite the higher protein adsorption. Additionally, our study indicates that unmodified PCL surfaces have the potential to trigger a strong humoral immune response, underscoring the importance of understanding these interactions for the development of personalized treatment approaches for patients with kidney failure.
Establishment of a chemoresistant laryngeal cancer cell model to study chemoresistance and chemosensitization responses via transcriptomic analysis and a tumor‐on‐a‐chip platform
Authors: Moya‐Garcia Christian R. , Munipalle Meghana , Pacis Alain , Sadeghi Nader , Tabrizian Maryam , Li‐Jessen Nicole Y. K. 
Published: January 2025

AbstractTumor resistance to chemotherapy is a common cause of cancer recurrence in patients with head and neck squamous cell carcinoma. The goal of this study is to establish and characterize a chemoresistant laryngeal cancer cell model and test its potential utility for chemosensitizing therapy. At the genotypic level, RNA sequencing confirmed that the cells acquired putative resistance with upregulated docetaxel‐resistant (DR) genes (e.g., TUBB3, CYP24A1) and signaling pathways (e.g., PI3K/mTOR, autophagy). For phenotypic analysis, DR cells were co‐cultured with laryngeal fibroblasts in a 2‐channel microfluidic chip that mimics a hypoxic tumor core in vivo. A drug sensitivity test with a chemosensitizer, metformin (MTF), was performed on the laryngeal tumor‐on‐a‐chip. Compared to non‐treated controls, MTF‐primed cancer cells exhibit higher sensitivity to docetaxel (DTX), that is, cell death. Collectively, this resistance‐acquired cell model displayed presumed genotypic and phenotypic profiles of chemoresistance providing a viable option for testing new therapeutic strategies for restoring tumor sensitivity to DTX.
Thriving in Opposition: The Effect of Boycotting on Narcissists' Well‐Being
Authors: Norman Elizabeth , Klaus Phil , Luong Van‐Ha 
Published: January 2025

ABSTRACTConsumer boycott is increasing, driven by value conflicts between individuals and brands. We hypothesize that narcissistic profiles affect the way that consumers experience the value conflicts implicit in a boycott, thereby affecting well‐being post‐boycott. We investigated well‐being outcomes for different narcissistic profiles for liberal and conservative boycotts. We analyzed data from 395 liberal and conservative boycott participants in the United States, exploring how narcissistic traits influence well‐being post‐boycott. Results showed that boycotting enhances the well‐being of grandiose narcissists but decreases the well‐being of vulnerable narcissists in both contexts. Interestingly, in conservative boycotts, the need for approval mitigates the well‐being decline for vulnerable narcissists, indicating that group validation may enhance their well‐being. These findings underscore the significance of political alignment, narcissistic traits, and social endorsement in influencing boycott‐related well‐being outcomes. Our study advances anti‐consumption literature by elucidating the psychological effects of consumer boycotts and the intricate interplay between narcissism and values on well‐being.
Early and Late Outcomes of Transcatheter Aortic Valve Replacement in Patients With Prior Chest Radiation: A Systematic Review and Meta‐Analysis
Authors: Tzoumas Andreas , Kyriakoulis Ioannis , Ntoumaziou Athina , Sagris Marios , Kampaktsis Polydoros N. 
Published: January 2025

ABSTRACTBackgroundPatients with prior history of chest or mediastinal radiation are deemed high risk for surgical AVR. Transcatheter aortic valve replacement (TAVR) has emerged as a promising alternative for these patients, however, this patient population was underrepresented in prior TAVR trials.AimsTo compare the outcomes of TAVR in patients with versus without a history of prior chest or mediastinal radiation.MethodsThis study was performed according to the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses guidelines. Systematic search of electronic databases was conducted up to September 2023. We compared early and late mortality as well as complications. A meta‐analysis was conducted with the use of a random effects model. The I‐square statistic was used to assess heterogeneity.ResultsSeven studies comprising 6358 patients were included in this meta‐analysis. Patients undergoing TAVR in the radiation group had a higher risk for heart failure exacerbation (OR: 2.06; 95% CI: 1.18–3.59) and aortic valve reintervention (OR: 5.68; 95% CI: 1.83–17.67) in the early postoperative period compared to the nonradiation group. Analysis revealed similar short‐term (in‐hospital or 30‐day) all‐cause‐mortality (OR: 1.63; 95% CI: 0.89–2.98) between the two groups. Other perioperative complications including myocardial infarction (MI), stroke, pacemaker insertion requirement, major bleeding as well as access‐related complications were not significantly different between the two groups. TAVR in the radiation group was not associated with increased all‐cause mortality compared to the nonradiation group (OR: 1.40; 95% CI: 0.93–2.11) after a mean follow‐up of 17.6 months. Other endpoints including MI, stroke, need for pacemaker insertion, heart failure readmission rate, and need for aortic valve reintervention were similar in the mid‐term follow‐up between the two groups.ConclusionTAVR in patients with a history of prior chest or mediastinal radiation was associated with similar short‐term and mid‐term mortality compared to patients without radiation. The history of chest or mediastinal radiation was associated with more frequent heart failure hospitalizations and aortic valve reintervention in the postoperative period. No difference was found in mid‐term complications. Future studies are warranted to validate our findings.
An Adaptive Connecting Equivalent Magnetic Network Considering Local Magnetic Characteristics for SPM Motors
Authors: Zhang Zhongyi , Li Bin , Ma Xiaochen , Li Guidan , Gao Peng 
Published: January 2025

ABSTRACTConsidering the local magnetic characteristics of surface‐mounted permanent magnet (SPM) motors, the paper proposes an adaptive connecting equivalent magnetic network (ACEMN) model to accurately predict SPM motor performance. First, for modeling the magnetic field at the inclined boundary of the stator pole shoe, a diagonal hybrid permeance element covering two materials is developed. And considering the parallel magnetization of PMs, a branching calculation of the magnetomotive force source is performed inside a cross‐shaped permeance of a fan‐shaped mesh. Then, by analyzing the phenomenon of magnetic field line deflection at the air gap boundary, an air gap node connecting way based on adaptive conversion of connecting permeances is built. Thereby, the rotating magnetic field of the air gap can be accurately described using the different connecting permeances with variable size. To accelerate the nonlinear solution for saturated element permeability, a hybrid iterative method is used. The validity of this modeling method is verified by finite element analysis (FEA) and prototype experiments, which allows a satisfactory compromise between accuracy and calculation speed.
On the Density–Density Correlations of the Non‐Interacting Finite Temperature Electron Gas
Authors: Tolias Panagiotis , Dornheim Tobias , Vorberger Jan 
Published: January 2025

ABSTRACTThe density–density correlations of the non‐interacting finite temperature electron gas are discussed in detail. Starting from the ideal linear density response function and utilizing general relations from linear response theory, known and novel expressions are derived for the pair correlation function, static structure factor, dynamic structure factor, thermal structure factor, and imaginary time correlation function. Applications of these expressions in the classical mapping approach, self‐consistent dielectric formalism and equation‐of‐state construction are analyzed in depth.
Evaluating biotic and abiotic drivers of avian community mobbing responses along urban gradients in Southern California
Authors: Ewing Benjamin , Wood Eric M. , Martínez Ari 
Published: January 2025

AbstractUrbanization is a significant pressure affecting wildlife and has the potential to greatly alter behavioral responses in animal communities. A behavioral response that is potentially affected by urbanization is the mobbing of predators by potential avian prey species. We tested three hypotheses concerning the effects of various abiotic and biotic factors in influencing avian mobbing responses along an urban–rural gradient. We conducted predator simulations by using playback of the vocalizations of the Western Screech‐owl, Megascops kennicottii, which is a predatory species that elicits a mobbing response from other birds. These vocalizations, accompanied by stuffed models of the screech‐owls, were broadcast at a variety of points along an urban–rural gradient in Los Angeles and Orange Counties in Southern California. We used an experimental approach using playback, that is, vocalization and models, to investigate whether mobbing responses of birds change in areas where predators may be naturally present (high vegetation density) or absent (high impervious cover). We recorded the number of individual birds and species that exhibited mobbing behavior at experimental sites, as well as various biotic and abiotic factors that may influence avian mobbing, including noise level, impervious surface cover, avian community turnover across the urban‐to‐rural gradient, and the structure of local vegetation, which we assumed may be important for either hosting roosting screech‐owls or providing cover for mobbing bird species. For both the number of mobbing individuals and species, we showed that mobbing responses decreased with increasing noise levels and percentage of impervious surfaces and increased with increasing woody vegetation. There was some evidence that predator presence influenced mobbing responses. Our results show that the changes associated with urbanization can significantly alter antipredator behavior in birds, and that these changes can alter avian social eavesdropping networks.