bluuebunny/crossref_metadata_2025_split huggingface dataset:
Radiomics analysis of substantia nigra on multi-echo susceptibility map-weighted imaging for differentiating Parkinson’s disease from atypical parkinsonian syndromes
Authors: Cheng Weiling , Zeng Wei , Guo Jiali , Dai Jiankun , Zhou Fuqing , Li Fangjun , Fang Xin 
Published: February 2025

Background While the “swallow tail” sign observed in the substantia nigra (SN) on susceptibility map-weighted imaging (SMWI) serves as an effective marker for differentiating patients with Parkinson's disease (PD) from healthy individuals, its visual assessment proves inadequate in differentiating PD from atypical Parkinson syndromes (APS). Purpose To employ radiomic features extracted from multi-echo SMWI of the SN to distinguish between PD and APS. Material and Methods SMWI data were acquired from 63 PD patients, 38 APS patients, and 89 healthy controls. The participants were randomly assigned to either training or test groups in a 7:3 proportion. Utilizing the PyRadiomics software, a set of radiomic features were extracted from SN for analysis. Features underwent standardization via the maximum-minimum method, with 166 statistically significant features identified through independent t-tests. To minimize the risk of overfitting, the least absolute shrinkage and selection operator (LASSO) algorithm was implemented to identify and select the five most significant features from the radiomic dataset. Five distinct machine-learning classifiers were developed to distinguish between PD, APS, and healthy controls. The SHapley Additive Explanations was employed to gain insights into and visualize the relative importance of each feature within these models. Results Morphological, first-order, texture, and wavelet transform features of the SN emerged as the most crucial determinants. The light gradient-boosting machine model demonstrated superior performance in distinguishing between PD, APS, and healthy controls. Conclusion Radiomic features of the SN derived from SMWI show promise in differentiating PD from APS, potentially enhancing diagnostic accuracy in clinical settings.
When Lateral Epicondylitis Is Not Lateral Epicondylitis: Analysis of the Risk Factors for the Misdiagnosis of Lateral Elbow Pain
Authors: Blonna Davide , Hoxha Norsaga , Greco Valentina , Rivoira Carolina , Bonasia Davide Edoardo , Rossi Roberto 
Published: February 2025

Background: Lateral elbow pain, often attributed to lateral epicondylitis, presents diagnostic complexities. Lateral epicondylitis, or tennis elbow, is the most frequent cause of lateral elbow pain, but a differential diagnosis among all the potential causes of lateral elbow pain is not easy. Purpose: To evaluate the rate of misdiagnoses in patients previously diagnosed with lateral epicondylitis, identify at-risk patient profiles, and determine sensitive clinical tests for a misdiagnosis. Study Design: Case series; Level of evidence, 4. Methods: A prospective analysis was conducted on 189 consecutive patients with a previous diagnosis of lateral epicondylitis and failed nonoperative treatment. According to medical history and a physical examination, patients were preliminarily classified into the typical or atypical lateral epicondylitis group. Atypical epicondylitis was defined as one of the following: atypical lateral pain location, history of trauma, limited range of motion (ROM), elbow swelling, negative Cozen test finding, and physical examination findings suggesting a misdiagnosis. Patients in the atypical group were further investigated for a potential lateral epicondylitis misdiagnosis using magnetic resonance imaging, computed tomography, and/or analysis of intraoperative samples according to suspected underlying abnormalities. Univariate and logistic regression analyses were conducted to assess the risk of a misdiagnosis. A standardized diagnostic analysis was performed to evaluate the clinical tests used during the physical examination to identify misdiagnosed patients. Results: A misdiagnosis occurred in 21 of 189 (11%) patients. The most common misdiagnoses were posterolateral elbow instability in 6 patients; radial nerve compression and inflammatory osteoarthritis in 3 patients each; and osteochondritis dissecans, posterolateral plica, and primary osteoarthritis in 2 patients each. The variables associated with a misdiagnosis were young age (≤30 years; odds ratio [OR], 66.90; P < .001), history of trauma (OR, 17.85; P = .0027), history of a limitation of ROM and/or mechanical symptoms (OR, 16.68; P = .0278), history of elbow swelling (OR, 14.32; P = .0032), and number of corticosteroid injections (OR, 2.00; P = .0007). Atypical lateral pain location highly predicted a misdiagnosis, with a sensitivity of 90.5%. Conclusion: A misdiagnosis can occur in patients affected by longstanding lateral elbow pain. Young patients and patients with a history of elbow trauma, a limitation of ROM, swelling, corticosteroid injections, and atypical lateral pain should be highly suspected for a misdiagnosis.
Evaluating Narrative Group Therapy on Self-Efficacy and Social Anxiety for Students with Dyslexia: A Randomized Controlled Trial
Authors: Chan Tak Mau Simon , Lau Chi Yuen Victor 
Published: February 2025

Purpose The present study aims to examine the effectiveness of narrative group therapy for improving self-efficacy as well as reducing social anxiety among primary school Chinese students with dyslexia in Hong Kong. Methods A cluster-level randomized controlled trial is used to conduct a thorough evaluation of the effectiveness of the intervention for 38 primary students who have been diagnosed with dyslexia. Results The pretest–posttest results reveal that narrative therapy has a significantly positive influence on self-efficacy (ηp2 = .18, p < .01) and social anxiety (ηp2 = .16, p < .01), which shows significant time by group interaction effects. Additionally, the results suggest that changes in self-efficacy fully mediate the impact of the intervention on changes in social anxiety. Conclusion This study concludes that narrative group therapy is effective for primary students with dyslexia, as the findings highlight the positive outcomes in terms of enhancing self-efficacy and mitigating social anxiety.
Optimizing the Host Niche to Fuel Cleft Lip Muscle Regeneration
Authors: He Pinting , Cheng Xu , Shi Qian , Li Chenghao , Shi Bing 
Published: February 2025

Objective Lip muscle reconstruction is a key strategy for cleft lip repair, but the outcome of muscle regeneration is suboptimal. The lack of relevant models restricts studies on cleft lip muscle regeneration. Design In this study, we developed an animal xenograft model by transplanting muscle samples from patients with cleft lip into different host sites in immunodeficient mice. The grafted muscles were harvested after 1, 2, and 5 months to investigate the temporal dynamics of myofiber growth and maturation. Comparisons were made among muscle biopsies, xenografts in the masseter (MAS) muscle of the mice, and xenografts in the tibialis anterior (TA) muscle of the mice to determine the optimal host niche. Histological analysis of myofiber number and size, fiber type switching, innervation, and blood supply was performed to evaluate the cleft lip muscle regeneration process. Results The muscles from cleft lip patients underwent an active degeneration-regeneration cycle. The fiber diameter in the MAS niche was significantly larger than that in the TA niche and was comparable to the fiber diameter of the donor biopsy from which it originated. The innervation and blood supply of the muscle grafts at the MAS host site were also superior to those of the grafts at the TA host site. Conclusions The MAS muscles of mice provided the most favorable microenvironment for cleft lip muscle regeneration. This patient-centered xenograft model offers a platform for cleft lip muscle regeneration studies.
The Direct Anterior Approach for AO/OTA43B and 43C Pilon Injuries
Authors: Sokil Laura E. , Wong Liam , Roti Elizabeth , DeKeyser Graham J. , Working Zachary M. , Friess Darin M. , Meeker James E. 
Published: February 2025

Background: Pilon fractures carry high rates of early wound healing, infectious complications, and late posttraumatic arthrosis. When reconstructive procedures are indicated, these patients are at further risk for early complications. Perhaps using the same direct anterior (DA) approach for initial repair and later reconstruction might mitigate these risks, but the DA approach has not been explored for initial repair. This study aimed to evaluate the performance of the DA approach for internal fixation of pilon fractures. We hypothesized that the reoperation rate for fractures treated with the DA approach would not differ from other surgical approaches in our series. Methods: A retrospective chart and radiographic review of operative Arbeitsgemeinschaft für Osteosynthesefragen/Orthopaedic Trauma Association (AO/OTA) 43B and C fractures from 2013 to 2022 were undertaken. Using Kaplan-Meier estimations, the likelihood of reoperation within 1 year of index surgery was analyzed. Reoperation risk factors were determined using multivariable logistic regression analyses created using a backward stepwise process. Results: A total of 135 fractures in 130 patients were eligible for review. The overall reoperation rate was 40.7%. There was no significant difference between DA and all other approaches for rate of reoperation for infection (2.3% vs 10%, P = .21), nonunion (15.9% vs 16.5%, P > .99), posttraumatic osteoarthritis (PTOA) (9.1% vs 7.8%, P > .99), and removal of symptomatic hardware (25% vs 36.3%, P = .27). In multivariate regression analysis, DA approach was associated with a lower rate of reoperation within 1 year (odds ratio 0.25, 95% CI 0.07-0.71, P = .015). Conclusion: The direct anterior approach can perform well for fixation of AO/OTA 43B and C fractures. Our retrospective series showed a favorable risk of reoperation at 1 year and a similar overall reoperation rate compared with all other combinations of approaches. Many factors determine the surgical approach to pilon fractures. This study has shown that the DA approach merits consideration as an option for open reduction and internal fixation.
Rapport in same and mixed neurotype groups of autistic and non-autistic adults
Authors: Foster Sarah J , Ackerman Robert A , Wilks Charlotte EH , Dodd Michelle , Calderon Rachel , Ropar Danielle , Fletcher-Watson Sue , Crompton Catherine J , Sasson Noah J 
Published: February 2025

Although autistic adults may establish better dyadic rapport with autistic relative to non-autistic partners, it is unclear whether this extends to group settings. The current study examined whether rapport differs between autistic groups, non-autistic groups, and mixed groups of autistic and non-autistic adults, and whether differing diagnostically from the rest of the group results in lower rapport. One hundred and forty-three adults were assigned to one of four group types of four participants each: all-autistic, all-non-autistic, non-autistic majority (three non-autistic, one autistic), and autistic majority (three autistic, one non-autistic). Groups participated in a 5-minute building activity and afterwards completed a 5-item rapport measure assessing their experience. The all-autistic groups did not differ on overall rapport from the all-non-autistic groups and had significantly higher rapport on two items (enjoying the interaction and friendliness of the group) than both types of mixed groups. At the individual level, autistic participants expressed more ease and enjoyment when interacting with other autistic adults relative to non-autistic adults, and their rapport declined as more non-autistic participants were included in the group. In contrast, rapport for non-autistic participants remained relatively consistent regardless of group composition. We discuss potential reasons why autistic participants were more affected by group composition than non-autistic participants. Lay abstract Autistic adults sometimes get along better with other autistic people compared to non-autistic people, but so far this has only been studied in two-person interactions. This study examined how well autistic and non-autistic people develop rapport in a group setting and whether rapport differs when group members share or do not share a diagnosis. We assigned 143 adults to 36 groups of four adults each. Some groups only had autistic members, some only had non-autistic members, and some were “mixed” groups of autistic and non-autistic members. Groups participated in a tower-building task for 5 minutes and afterwards completed a survey about rapport with the group. The groups of all-autistic participants expressed that their interactions were more enjoyable and friendly than the mixed groups. Autistic participants reported lower rapport when interacting with non-autistic adults, while non-autistic participants reported similar rapport whether interacting with autistic or non-autistic group members. Overall, findings are not consistent with a social deficit model of autism, as autistic adults often established rapport with partners in a group setting. Their level of rapport, however, depended strongly on the social context, particularly whether other autistic people were also in the group.
Mechanical properties and joinability of the near-eutectic aluminium casting alloy AlSi12
Authors: Neuser M. , Holtkamp P.-K. , Hoyer K.-P. , Kappe F. , Yildiz S. , Bobbert M. , Meschut G. , Schaper M. 
Published: February 2025

One of the most important strategies for reducing CO2 emissions in the mobility sector is lightweight construction. In particular, the car body offers several opportunities for weight reduction. Multi-material designs are increasingly being applied to select the most suitable material for the respective load and ultimately achieve synergy effects. For example, aluminium castings are used at the nodes of a spaceframe body. Subsequently, these are joined with profiles to form the bodyshell. To join different materials mechanical joining techniques, such as semi-tubular self-piercing riveting, are deployed. According to the current state of the art, cracks occur in the aluminium castings during the mechanical joining process as a result of the high degree of deformation. Although the aluminium casting alloys of the AlSi-system exhibit low ductility, these alloys reveal excellent castability. In particular, the ability to cast thin structural parts is enabled by the low liquidus point of the near eutectic aluminium casting alloys. This study addresses the mechanical joining properties of the near eutectic aluminium casting alloy AlSi12, depending on different microstructures. These are achieved by annealing processes and modifying agents. Through an adapted heat treatment, the previously lamellar morphology can be transformed into a globular morphology, which leads to increased ductility and prevents the formation of cracks during the self-piercing riveting (SPR). The joinability is investigated using different die geometries, whereas the joint formation is analysed regarding crack initiation. To evaluate the increased ductility, microstructural and mechanical tests are performed and finally, a microstructure-joinability correlation is established.
Improved healing and functional outcome is seen at 12 months after injecting leukocyte rich-PRP in arthroscopically repaired labrum: A case-control study
Authors: Azharuddin Sheikh , Gahlot Nitesh , Elhence Abhay , Garg Pawan , Mandal Saptarshi , Saxena Suvinay 
Published: February 2025

Introduction A study with the hypothesis: platelet-rich plasma (PRP) injection into labrum repair will produce better healing response and improved functional outcome in patients of recurrent shoulder dislocation treated with arthroscopic Bankart repair. Methods Arthroscopically repaired recurrent shoulder dislocation patients. Group 1 (cases): administered LR-PRP injection. Group 2 (controls): not received PRP injection. The injection was given arthroscopically at the labrum-bone interface after repair was completed. Results A total of 40 patients: 20 in group I (cases) and 20 in group II (controls). The mean age was 26 ± 6 years; 36 patients (90%) were male and 4 patients (10%) were female. All three scores showed improvement at follow-up evaluation inside the groups ( P < .001). Individual score improvement was more in group I, the difference was statistically significant for the American Shoulder and Elbow Surgeon (ASES) and Disabilities of the Arm, Shoulder and Hand (DASH) scores ( P < .05). The CSS was also higher in group I (93.2 ± 2.8) at follow-up as compared to group II (91.5 ± 2.7, P = .063). Follow-up magnetic resonance imaging (MRI) evaluation showed improvement in labral height ( P < .05), Labrum height glenoid index ( P > .05), and Labral slope ( P < .05) in both the groups, the increase was more in group I as compared to group II. Conclusion PRP injection at the labrum-bone interface provides a better healing response in the labrum and better functional outcomes at 12 months after arthroscopic bankart repair. Level of evidence Level III, case-control study
Predictors and Postoperative Complication Risks for Revision Discectomies Following Primary Lumbar Microdiscectomy
Authors: Ton Andy , Avetisian Henry , Han Jane , Mertz Kevin , Shontz Edward , Hang Nicole , Abdou Marc , Athari Mirbahador , Karakash Will , Wang Jeffrey C. , Hah Raymond J. , Alluri Ram K. 
Published: February 2025

Study Design Retrospective cohort analysis. Objective Identify demographic and clinical predictors for revision discectomy and compare postoperative complications between primary microdiscectomy (MD) and revision discectomy. Methods Patients who underwent one-level primary lumbar MD and subsequent one-level revision discectomy for lumbar disc herniation were identified using the PearlDiver national database. Multivariate regression analysis was performed to identify predictors of revision discectomy, assess 30-day postoperative complications and opioid use, and assess the likelihood of future lumbar fusion. Results Of 52,310 patients undergoing primary lumbar MD, 4536 (7.98%) required revision. Independent predictors included smoking (aOR: 1.72), obesity (aOR: 1.44), lateral disc herniation (aOR: 1.69), coagulopathies (aOR: 1.34), CAD (aOR: 1.62), anemia (aOR: 1.38), diabetes (aOR: 1.47), hypertension (aOR: 1.63), peripheral vascular disease (aOR:1.33), preoperative opioid use (aOR: 2.06), postoperative opioid use (aOR: 1.80), and depression (aOR: 1.73) (all, P < 0.01). Revision discectomy was associated with higher risks of infection (aOR: 1.78), AKI (aOR: 1.41), VTE (aOR: 1.46), dehiscence (aOR: 2.32), neurological injury (aOR: 1.48), durotomy (aOR: 2.19), epidural hematoma (aOR: 2.61), I&D (aOR: 2.32), opioid use (aOR: 1.73), and increased fusion rates (all P < 0.05). Conclusion Several patient-related factors increase the risk of revision MD, which is associated with additional short- and long-term complication risks relative to the index procedure. These findings inform expectations for disease progression and postoperative outcomes in revision MD. Revision discectomy should be avoided when possible.
Whole-genome mapping reveals QTLs linked to key agronomic traits in bi-parental populations of field cress (Lepidium campestre)
Authors: Abreha Kibrom B. , Hammenhag Cecilia , Seifert Felix , Geleta Mulatu 
Published: February 2025

Abstract

Background
Field cress, Lepidium campestre, is an oil and catch crop undergoing domestication for the Nordic region. In this study, the genetic bases of domestication-related traits of field cress are identified using three bi-parental F2 mapping populations (MPs). The MPs were phenotyped for plant height (PH), inflorescence length (IL), pod density (PD), seed yield per plant (SYPP), seed dormancy (SD), and pod shattering measured with two different parameters (PSH1 and PSH2).

Results
The MPs were genotyped, with a targeted Genotyping-by-sequencing (GBS) method, SeqSNP, using 9,378 Single Nucleotide Polymorphisms (SNP) spanning across eight linkage groups (LGs) of field cress. There was wide phenotypic variation among the individuals for the agronomic traits measured in all MPs. A linkage map was constructed for each MP by mapping high-quality SNPs spanning 607 cM, 893 cM, and 732 cM to the eight field cress LGs, in each of the respective MPs. Quantitative trait loci (QTLs) mapping identified nine QTLs linked to PSH2, three for PH, two for SYPP, and one each for SD, IL, and PD distributed across all LGs. Taking advantage of field cress genome synteny with Arabidopsis thaliana chromosomes, annotation of the genes found within a major QTL for PSH2 found in LG5 (for MP3) revealed putative roles related to flowering, seed, and siliques development, cellulose and lignin biosynthesis, and water loss prevention.

Conclusion
This study identified QTLs for multiple domestication-related traits and provides genomic resources useful for applying novel breeding tools to accelerate field cress domestication and improvement.
Healthcare-seeking behaviors and barriers among medical students in Egypt: a national cross-sectional study
Authors: El-Khawaga Ghada O. , Omar Yusof M. , Elsaadany Mohamed , Ghazy Mohamed , Abdelaal Amr Khaled , Hekal Mahmoud , El-Gilany Abdel-Hady ,   H. S. B. team of collaborators, Wagih Huda , Bastawi Mey E. , Khalaf Tala Abu , Ahmed Youssef , Essam Mazen , Darwish Nour Edin , Elfagal Mohamed Mahmoud , Hamdy Sondos , Abady Abdelrahman Mahmoud 
Published: February 2025

Abstract

Background
Medical students are particularly vulnerable to acquiring various health conditions due to the nature of their education but often hesitate to consult doctors and resort to self-managing their illnesses. This study aims to examine the healthcare-seeking behaviors and barriers among medical students in Egypt.

Methods
This cross-sectional study involved a convenience sample of 1,535 medical students from 12 public universities across Egypt. Data on healthcare-seeking behaviors, barriers, and associated factors were collected using an online survey distributed through official university channels and social media platforms. Logistic regression analysis was used to identify factors associated with consulting a doctor when experiencing health problems.

Results
Only 52.2% of participants reported consulting doctors when ill. Participants from rural backgrounds (COR = 0.69, CI: 0.51–0.93), those facing barriers to healthcare (COR = 0.80, CI: 0.66–0.98), with less than sufficient income (COR = 0.61, CI: 0.46–0.81), or a non-working mother (AOR = 0.76, CI: 0.58–0.99) were less likely to consult a doctor. In contrast, participants with more than sufficient income (COR = 1.35, CI: 1.02–1.78), a parent in healthcare (AOR = 13.18–17.31, CI: 6.87–36.35), or who exercised regularly (AOR = 1.48, CI: 1.09–2.01) were more likely to consult a doctor. A substantial proportion of students reported relying on past experiences with the illness (54.1%), using the Internet (46.8%), and self-diagnosing (36.2%). The most common reported barriers to seeking healthcare were lack of time (29.2%), long wait times (22.7%), and academic concerns (12%). A history of feeling uncomfortable or discriminated against when seeking healthcare was reported by 19.5% of participants.

Conclusion
Many medical students in Egypt engage in self-diagnosis and self-management rather than consulting doctors when ill. Addressing healthcare barriers is crucial for encouraging appropriate care-seeking behaviors within this population.