bluuebunny/crossref_metadata_2025_split huggingface dataset:
Using Machine Learning With Partial Dependence Analysis to Investigate Coupling Between Soil Moisture and Near‐Surface Temperature
Authors: Trok Jared T. , Davenport Frances V. , Barnes Elizabeth A. , Diffenbaugh Noah S. 
Published: June 2023

AbstractSoil moisture (SM) influences near‐surface air temperature by partitioning downwelling radiation into latent and sensible heat fluxes, through which dry soils generally lead to higher temperatures. The strength of this coupled soil moisture‐temperature (SM‐T) relationship is not spatially uniform, and numerous methods have been developed to assess SM‐T coupling strength across the globe. These methods tend to involve either idealized climate‐model experiments or linear statistical methods which cannot fully capture nonlinear SM‐T coupling. In this study, we propose a nonlinear machine‐learning (ML)‐based approach for analyzing SM‐T coupling and apply this method to various mid‐latitude regions using historical reanalysis datasets. We first train convolutional neural networks (CNNs) to predict daily maximum near‐surface air temperature (TMAX) given daily SM and geopotential height fields. We then use partial dependence analysis to isolate the average sensitivity of each CNN's TMAX prediction to the SM input under daily atmospheric conditions. The resulting SM‐T relationships broadly agree with previous assessments of SM‐T coupling strength. Over many regions, we find nonlinear relationships between the CNN's TMAX prediction and the SM input map. These nonlinearities suggest that the coupled interactions governing SM‐T relationships vary under different SM conditions, but these variations are regionally dependent. We also apply this method to test the influence of SM memory on SM‐T coupling and find that our results are consistent with previous studies. Although our study focuses specifically on local SM‐T coupling, our ML‐based method can be extended to investigate other coupled interactions within the climate system using observed or model‐derived datasets.
Tongan Volcanic Eruption Induced Global‐Scale Thermospheric Changes Observed by the GOLD Mission
Authors: Aryal S. , Gan Q. , Evans J. S. , Laskar F. I. , Karan D. K. , Cai X. , Greer K. R. , Wang W. , McClintock W. E. , Eastes R. W. 
Published: June 2023

AbstractThe 2022 Tongan volcanic eruption released significant energy into the atmosphere. Tropospheric satellite images show that the eruption generated pressure waves that traveled globally. The Global Observation of the Limb and Disk (GOLD) mission observed significant wave‐like thermospheric temperature perturbations (>100 K) from 12 to 16 UT. These temperature perturbations' spatial curvatures and arrival times are initially similar to the tropospheric wave‐fronts but differ significantly with eastward propagation. The perturbations had a phase speed of ∼300–400 m/s and wavelengths greater than 2,400 km. Near‐concurrent Ionospheric Connection Explorer neutral wind measurements suggest that the eruption's effects reversed the direction of the prevailing thermospheric zonal winds around the perturbed regions. The eruption's global and whole atmospheric effects provide a unique opportunity to study how different atmospheric layers exchange energy and momentum during explosive events. GOLD's synoptic observations are uniquely positioned to study these effects in the middle thermosphere.
Efficacy and safety of isatuximab plus bortezomib, lenalidomide, and dexamethasone in patients with newly diagnosed multiple myeloma ineligible/with no immediate intent for autologous stem cell transplantation
Authors: Ocio Enrique M. , Perrot Aurore , Bories Pierre , San-Miguel Jesus F. , Blau Igor W. , Karlin Lionel , Martinez-Lopez Joaquin , Wang Song-Yau , Bringhen Sara , Marcatti Magda , Mateos María-Victoria , Rodriguez-Otero Paula , Oliva Stefania , Nogai Axel , Le Roux Nadia , Dong Liyan , Macé Sandrine , Gassiot Matthieu , Fitzmaurice Thomas , Oprea Corina , Moreau Philippe 
Published: June 2023

AbstractPatients with newly diagnosed multiple myeloma (NDMM) ineligible for autologous stem cell transplantation (ASCT) have lower survival rates and may benefit from frontline regimens that include novel agents. This Phase 1b study (NCT02513186) evaluated preliminary efficacy, safety, and pharmacokinetics (PK) of isatuximab, an anti-CD38 monoclonal antibody, combined with bortezomib-lenalidomide-dexamethasone (Isa-VRd) in patients with NDMM ineligible for/with no intent for immediate ASCT. Overall, 73 patients received four 6-week induction cycles of Isa-VRd, then maintenance with Isa-Rd in 4-week cycles. In the efficacy population (n = 71), the overall response rate was 98.6%, with 56.3% achieving a complete response or better (sCR/CR), and 36/71 (50.7%) patients reaching minimal residual disease negativity (10−5 sensitivity). Grade ≥3 treatment-emergent adverse events (TEAEs) occurred in 79.5% (58/73) of patients but TEAEs leading to permanent study treatment discontinuation were reported in 14 (19.2%) patients. Isatuximab PK parameters were within the previously reported range, suggesting that VRd does not alter the PK of isatuximab. These data support additional studies of isatuximab in NDMM, such as the Phase 3 IMROZ study (Isa-VRd vs VRd).
Co-encapsulation of curcumin and quercetin with zein/HP-β-CD conjugates to enhance environmental resistance and antioxidant activity
Authors: Qiu Chao , Zhang Zhiheng , Li Xiaojing , Sang Shangyuan , McClements David Julian , Chen Long , Long Jie , Jiao Aiquan , Xu Xueming , Jin Zhengyu 
Published: June 2023

AbstractIn this study, composite nanoparticles consisting of zein and hydroxypropyl beta-cyclodextrin were prepared using a combined antisolvent co-precipitation/electrostatic interaction method. The effects of calcium ion concentration on the stability of the composite nanoparticles containing both curcumin and quercetin were investigated. Moreover, the stability and bioactivity of the quercetin and curcumin were characterized before and after encapsulation. Fluorescence spectroscopy, Fourier Transform infrared spectroscopy, and X-ray diffraction analyses indicated that electrostatic interactions, hydrogen bonding, and hydrophobic interactions were the main driving forces for the formation of the composite nanoparticles. The addition of calcium ions promoted crosslinking of the proteins and affected the stability of the protein–cyclodextrin composite particles through electrostatic screening and binding effects. The addition of calcium ions to the composite particles improved the encapsulation efficiency, antioxidant activity, and stability of the curcumin and quercetin. However, there was an optimum calcium ion concentration (2.0 mM) that provided the best encapsulation and protective effects on the nutraceuticals. The calcium crosslinked composite particles were shown to maintain good stability under different pH and simulated gastrointestinal digestion conditions. These results suggest that zein–cyclodextrin composite nanoparticles may be useful plant-based colloidal delivery systems for hydrophobic bio-active agents.
Microstructural brain tissue changes contribute to cognitive and mood deficits in adults with type 2 diabetes mellitus
Authors: Roy Bhaswati , Choi Sarah E , Freeby Matthew J. , Kumar Rajesh 
Published: June 2023

AbstractType 2 diabetes mellitus (T2DM) patients show brain tissue changes in mood and cognitive regulatory sites, but the nature and extent of tissue injury and their associations with symptoms are unclear. Our aim was to examine brain tissue damage in T2DM over controls using mean diffusivity (MD) computed from diffusion tensor imaging (DTI), and assess correlations with mood and cognitive symptoms in T2DM. We collected DTI series (MRI), mood, and cognitive data, from 169 subjects (68 T2DM and 101 controls). Whole-brain MD-maps were calculated, normalized, smoothed, and compared between groups, as well as correlated with mood and cognition scores in T2DM subjects. Type 2 diabetes patients showed altered cognitive and mood functions over control subjects. Multiple brain sites in T2DM patients showed elevated MD values, indicating chronic tissue changes, including the cerebellum, insula, and frontal and prefrontal cortices, cingulate, and lingual gyrus. Associations between MD values and mood and cognition scores appeared in brain sites mediating these functions. Type 2 diabetes patients show predominantly chronic brain tissue changes in areas mediating mood and cognition functions, and tissue changes from those regions correlate with mood and cognitive symptoms suggesting that the microstructural brain changes may account for the observed functional deficits.
Cancer-associated fibroblast-derived exosome microRNA-21 promotes angiogenesis in multiple myeloma
Authors: Miaomiao Sun , Xiaoqian Wang , Yuwei Shou , Chao Chen , Chenbo Yang , Yinghao Liang , Yichen Hong , Jiao Shu , Kuisheng Chen 
Published: June 2023

AbstractMultiple myeloma (MM) is the second most common hematological malignancy, and angiogenesis determines its progression. In the tumor microenvironment, normal fibroblasts (NFs) are transformed into cancer-associated fibroblasts (CAFs), which can promote angiogenesis. Microribonucleic acid-21 (miR-21) is highly expressed in various tumors. However, research on the relationship between tumor angiogenesis and miR-21 is rare. We analyzed the relationship between miR-21, CAFs, and angiogenesis in MM. NFs and CAFs were isolated from the bone marrow fluids of patients with dystrophic anemia and newly-diagnosed MM. Co-culturing of CAF exosomes with multiple myeloma endothelial cells (MMECs) showed that CAF exosomes were able to enter MMECs in a time-dependent manner and initiate angiogenesis by promoting proliferation, migration, and tubulogenesis. We found that miR-21 was abundant in CAF exosomes, entering MMECs and regulating angiogenesis in MM. By transfecting NFs with mimic NC, miR-21 mimic, inhibitor NC, and miR-21 inhibitor, we found that miR-21 significantly increased the expression of alpha-smooth muscle actin and fibroblast activation protein in NFs. Our results showed that miR-21 can transform NFs into CAFs, and that CAF exosomes promote angiogenesis by carrying miR-21 into MMECs. Therefore, CAF-derived exosomal miR-21 may serve as a novel diagnostic biomarker and therapeutic target for MM.
Starvation hardiness as preadaptation for life in subterranean habitats
Authors: Kozel Peter , Novak Tone , Janžekovič Franc , Lipovšek Saška 
Published: June 2023

AbstractMost subterranean habitats, especially caves, are considered extreme environments, mainly because of the limited and erratic food supply and constant darkness. In temperate regions, many climatic conditions, such as temperature and air humidity, are periodically less adverse or even more favourable in caves than the harsh seasonal weather on the surface. Accordingly, many animal species search for hibernacula in caves. These overwintering, non-specialized subterranean species (non-troglobionts) show various modes of dormancy and ongoing development. Since they do not feed, they all undergo periodic starvation, a preadaptation, which might evolve in permanent starvation hardiness, such as found in most specialized subterranean species (troglobionts). To this end, we performed a comparative analysis of energy-supplying compounds in eleven most common terrestrial non-troglobiont species during winter in central European caves. We found highly heterogeneous responses to starvation, which are rather consistent with the degree of energetic adaptation to the habitat than to overwintering mode. The consumption of energy-supplying compounds was strongly higher taxa-dependant; glycogen is the main energy store in gastropods, lipids in insects, and arachnids rely on both reserve compounds. We assume that permanent starvation hardiness in specialized subterranean species might evolved in many different ways as shown in this study.
Relationship between circulating tumour DNA and skeletal muscle stores at diagnosis of pancreatic ductal adenocarcinoma: a cross-sectional study
Authors: Hanna Lauren , Sellahewa Rav , Huggins Catherine E. , Lundy Joanne , Croagh Daniel 
Published: June 2023

AbstractLow skeletal muscle index (SMI) and low skeletal muscle radiodensity (SMD) are associated with reduced survival time in pancreatic ductal adenocarcinoma (PDAC). The negative prognostic impact of low SMI and low SMD is often reported as independent of cancer stage when using traditional clinical staging tools. Therefore, this study sought to explore the relationship between a novel marker of tumour burden (circulating tumour DNA) and skeletal muscle abnormalities at diagnosis of PDAC. A retrospective cross-sectional study was conducted in patients who had plasma and tumour tissue samples stored in the Victorian Pancreatic Cancer Biobank (VPCB) at diagnosis of PDAC, between 2015 and 2020. Circulating tumour DNA (ctDNA) of patients with G12 and G13 KRAS mutations was detected and quantified. Pre-treatment SMI and SMD derived from analysis of diagnostic computed tomography imaging was tested for its association to presence and concentration of ctDNA, as well as conventional staging, and demographic variables. The study included 66 patients at PDAC diagnosis; 53% female, mean age 68.7 years (SD ± 10.9). Low SMI and low SMD were present in 69.7% and 62.1% of patients, respectively. Female gender was an independent risk factor for low SMI (OR 4.38, 95% CI 1.23–15.55, p = 0.022), and older age an independent risk factor for low SMD (OR 1.066, 95% CI 1.002–1.135, p = 0.044). No association between skeletal muscle stores and concentration of ctDNA (SMI r = − 0.163, p = 0.192; SMD r = 0.097, p = 0.438) or stage of disease according to conventional clinical staging [SMI F(3, 62) = 0.886, p = 0.453; SMD F(3, 62) = 0.717, p = 0.545] was observed. These results demonstrate that low SMI and low SMD are highly prevalent at diagnosis of PDAC, and suggest they are comorbidities of cancer rather than related to the clinical stage of disease. Future studies are needed to identify the mechanisms and risk factors for low SMI and low SMD at diagnosis of PDAC to aid screening and intervention development.
Cisplatin-induced increase in heregulin 1 and its attenuation by the monoclonal ErbB3 antibody seribantumab in bladder cancer
Authors: Steele Thomas M. , Tsamouri Maria Malvina , Siddiqui Salma , Lucchesi Christopher A. , Vasilatis Demitria , Mooso Benjamin A. , Durbin-Johnson Blythe P. , Ma Ai-Hong , Hejazi Nazila , Parikh Mamta , Mudryj Maria , Pan Chong-xian , Ghosh Paramita M. 
Published: June 2023

AbstractCisplatin-based combination chemotherapy is the foundation for treatment of advanced bladder cancer (BlCa), but many patients develop chemoresistance mediated by increased Akt and ERK phosphorylation. However, the mechanism by which cisplatin induces this increase has not been elucidated. Among six patient-derived xenograft (PDX) models of BlCa, we observed that the cisplatin-resistant BL0269 express high epidermal growth factor receptor, ErbB2/HER2 and ErbB3/HER3. Cisplatin treatment transiently increased phospho-ErbB3 (Y1328), phospho-ERK (T202/Y204) and phospho-Akt (S473), and analysis of radical cystectomy tissues from patients with BlCa showed correlation between ErbB3 and ERK phosphorylation, likely due to the activation of ERK via the ErbB3 pathway. In vitro analysis revealed a role for the ErbB3 ligand heregulin1-β1 (HRG1/NRG1), which is higher in chemoresistant lines compared to cisplatin-sensitive cells. Additionally, cisplatin treatment, both in PDX and cell models, increased HRG1 levels. The monoclonal antibody seribantumab, that obstructs ErbB3 ligand-binding, suppressed HRG1-induced ErbB3, Akt and ERK phosphorylation. Seribantumab also prevented tumor growth in both the chemosensitive BL0440 and chemoresistant BL0269 models. Our data demonstrate that cisplatin-associated increases in Akt and ERK phosphorylation is mediated by an elevation in HRG1, suggesting that inhibition of ErbB3 phosphorylation may be a useful therapeutic strategy in BlCa with high phospho-ErbB3 and HRG1 levels.
A ROCK inhibitor suppresses the transforming growth factor-beta-2-induced endothelial–mesenchymal transition in Schlemm’s canal endothelial cells
Authors: Fujimoto Tomokazu , Inoue-Mochita Miyuki , Inoue Toshihiro 
Published: June 2023

AbstractIn the normal eye, most of the aqueous humor drains through the trabecular meshwork (TM) and Schlemm’s canal (SC). The concentration of transforming growth factor beta 2 (TGF-β2) is increased in the aqueous humor of primary open angle glaucoma patients. TGF-β2 increases outflow resistance by affecting the TM and SC, and endothelial–mesenchymal transition (EndMT) of SC cells is involved in these changes. Here, we investigated the effect of a ROCK inhibitor on TGF-β2-induced EndMT in SC cells. The ROCK inhibitor Y-27632 suppressed the TGF-β2-induced increase in the trans-endothelial electrical resistance (TER) and proliferation of SC cells. Y-27632 suppressed the expression of α-SMA, N-cadherin, and Snail, which are upregulated by TGF-β2. Moreover, TGF-β2 decreased mRNA levels of bone morphogenetic protein (BMP) 4 and increased those of the BMP antagonist gremlin (GREM1), but Y-27632 significantly suppressed these changes. Y-27632 also inhibited TGF-β2-induced phosphorylation of p-38 mitogen-activated protein kinase (MAPK). BMP4 and the p-38 MAPK inhibitor SB203580 suppressed the TGF-β2-induced TER elevation in SC cells. Moreover, SB203580 suppressed TGF-β2-induced upregulation of fibronectin, Snail, and GREM1. These results indicate that a ROCK inhibitor inhibited the TGF-β2-induced EndMT in SC cells, implying the involvement of p38 MAPK and BMP4 signaling.
Sex, sepsis and the brain: defining the role of sexual dimorphism on neurocognitive outcomes after infection
Authors: Polcz Valerie E. , Barrios Evan L. , Chapin Benjamin , Price Catherine C. , Nagpal Ravinder , Chakrabarty Paramita , Casadesus Gemma , Foster Thomas , Moldawer Lyle L. , Efron Philip A. 
Published: June 2023

Abstract
Sexual dimorphisms exist in multiple domains, from learning and memory to neurocognitive disease, and even in the immune system. Male sex has been associated with increased susceptibility to infection, as well as increased risk of adverse outcomes. Sepsis remains a major source of morbidity and mortality globally, and over half of septic patients admitted to intensive care are believed to suffer some degree of sepsis-associated encephalopathy (SAE). In the short term, SAE is associated with an increased risk of in-hospital mortality, and in the long term, has the potential for significant impairment of cognition, memory, and acceleration of neurocognitive disease. Despite increasing information regarding sexual dimorphism in neurologic and immunologic systems, research into these dimorphisms in sepsis-associated encephalopathy remains critically understudied. In this narrative review, we discuss how sex has been associated with brain morphology, chemistry, and disease, sexual dimorphism in immunity, and existing research into the effects of sex on SAE.
A monocular image depth estimation method based on weighted fusion and point‐wise convolution
Authors: Lei Chen , Zhengyou Liang , Yu Sun 
Published: June 2023

AbstractThe existing monocular depth estimation methods based on deep learning have difficulty in estimating the depth near the edges of the objects in an image when the depth distance between these objects changes abruptly and decline in accuracy when an image has more noises. Furthermore, these methods consume more hardware resources because they have huge network parameters. To solve these problems, this paper proposes a depth estimation method based on weighted fusion and point‐wise convolution. The authors design a maximum‐average adaptive pooling weighted fusion module (MAWF) that fuses global features and local features and a continuous point‐wise convolution module for processing the fused features derived from the (MAWF) module. The two modules work closely together for three times to perform weighted fusion and point‐wise convolution of features of multi‐scale from the encoder output, which can better decode the depth information of a scene. Experimental results show that our method achieves state‐of‐the‐art performance on the KITTI dataset with δ1 up to 0.996 and the root mean square error metric down to 8% and has demonstrated the strong generalisation and robustness.
Compton-thick AGN in the NuSTAR Era X: Analysing seven local CT-AGN candidates
Authors: Sengupta D. , Marchesi S. , Vignali C. , Torres-Albà N. , Bertola E. , Pizzetti A. , Lanzuisi G. , Salvestrini F. , Zhao X. , Gaspari M. , Gilli R. , Comastri A. , Traina A. , Tombesi F. , Silver R. , Pozzi F. , Ajello M. 
Published: June 2023

Context. We present the broad-band X-ray spectral analysis (0.6–50 keV) of seven Compton-thick active galactic nuclei (CT-AGN; line-of-sight (LOS) column density > 1024 cm−2) candidates selected from the Swift-BAT 100 month catalogue using archival NuSTAR data.
Aims. We aim to obtain a complete census of the heavily obscured AGN in the local Universe (z < 0.05).
Methods. This work is in continuation of the ongoing research of the Clemson-INAF group to classify CT-AGN candidates at redshift z < 0.05 using physically motivated torus models.
Results. Our results confirm that three out of seven targets are bona fide CT-AGN. Adding our results to the previously analysed sources using NuSTAR data, we increase the population of bona fide CT-AGN by ∼9%, bringing the total number to 35 out of 414 AGN. We also performed a comparative study using MYTorus and borus02 on the spectra in our sample, finding that both physical models are strongly consistent in the parameter space of LOS column density and photon index. Furthermore, we also investigate the clumpiness of the torus clouds by separately computing the LOS and average torus column densities in each of the seven sources. Adding our results to all the previous 48 CT-AGN candidates analysed by the Clemson-INAF research team for which NuSTAR observations are available, we find that 78% of the sources are likely to have a clumpy distribution of the obscuring material surrounding the accreting supermassive black hole.