bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mind of a dauer: Comparative connectomics reveals developmental plasticity
Authors: Yim Hyunsoo , Choe Daniel T. , Bae J. Alexander , Kang Hae-Mook , Nguyen Ken C.Q. , Choi Myung-kyu , Ahn Soungyub , Bahn Sang-kyu , Yang Heeseung , Hall David H. , Kim Jinseop S. , Lee Junho 
Published: March 2023

SummaryA fundamental question in neurodevelopmental biology is how flexibly the nervous system changes during development. To address this, we reconstructed the complete connectome of dauer, an alternative developmental stage of nematodes with distinct behavioral characteristics, by volumetric reconstruction and automated synapse detection using deep learning. With the basic architecture of the nervous system preserved, structural changes in neurons, large or small, were closely associated with connectivity changes, which in turn evoked dauer-specific behaviors such as nictation. Graph theoretical analyses revealed significant dauer-specific rewiring of sensory neuron connectivity and increased clustering within motor neurons in the dauer connectome. We suggest that the nervous system in the nematode, probably animals in general, has evolved to respond to harsh environments by reversibly developing a quantitatively and qualitatively differentiated connectome.
Hepatic conversion of acetyl-CoA to acetate plays crucial roles in energy stresses
Authors: Wang Jinyang , Wen Yaxin , Zhao Wentao , Zhang Yan , Lin Furong , Ouyang Cong , Wang HuiHui , Yao Lizheng , Ma Huanhuan , Zhuo Yue , Huang Huiying , Shi Xiulin , Feng Liubin , Lin Donghai , Jiang Bin , Li Qinxi 
Published: March 2023

AbstractAccumulating evidences indicate that acetate is increased in energy stresses such as diabetes mellitus and prolonged starvation. However, it is largely unknown how and where acetate is produced and what is its biological significance. We observed overproduction of acetate in an amount comparable to ketone bodies in patients and mice with diabetes or starvation. Mechanistically, ACOT 12&8 are dramatically upregulated in liver to convert FFA-derived acetyl-CoA to acetate and CoA. This conversion not only provides large amount of acetate which fuels brain preferentially rather than muscle, but also recycles CoA which is required for sustained fatty acid oxidation and ketogenesis. Taken together, we suggest that acetate is an emerging novel “ketone body” and may be used as a parameter to evaluate the progression of energy stress in the future.
De novoserine biosynthesis is protective in mitochondrial disease
Authors: Jackson Christopher B , Marmyleva Anastasiia , Awadhpersad Ryan , Monteuuis Geoffray , Mito Takayuki , Zamboni Nicola , Tatsuta Takashi , Vincent Amy E. , Wang Liya , Langer Thomas , Carroll Christopher J , Suomalainen Anu 
Published: March 2023

AbstractImportance of serine as a metabolic regulator is well known in tumors and raising attention also in degenerative diseases. Recent data indicate thatde novoserine biosynthesis is an integral component of metabolic response to mitochondrial disease, but the roles of the response have remained unknown. Here, we report that glucose-drivende novoserine biosynthesis maintains metabolic homeostasis in energetic stress. Pharmacological inhibition of the rate-limiting enzyme, phosphoglycerate dehydrogenase (PHGDH), aggravated mitochondrial muscle disease, suppressed oxidative phosphorylation and mitochondrial translation, altered whole-cell lipid profiles and enhanced mitochondrial integrated stress response (ISRmt),in vivo,in skeletal muscle and in cultured cells. Our evidence indicates thatde novoserine biosynthesis is essential to maintain mitochondrial respiration, redox balance, and cellular lipid homeostasis in skeletal muscle with mitochondrial dysfunction. Our evidence implies that interventions activatingde novoserine synthesis may protect against mitochondrial failure in the skeletal muscle.Bullet pointsSerine becomes an essential amino acid in mitochondrial translation defectsBlockingde novoserine biosynthesis promotes progression of mitochondrial diseaseDe novoserine biosynthesis maintains phospholipid homeostasis upon mitochondrial insultSerine biosynthesis sustains redox-balance and mitochondrial translation in disease
Fluorescent Sensors for Imaging Interstitial Calcium
Authors: Valiente-Gabioud Ariel A. , Suñer Inés Garteizgogeascoa , Idziak Agata , Fabritius Arne , Angibaud Julie , Basquin Jérome , Nägerl U. Valentin , Singh Sumeet Pal , Griesbeck Oliver 
Published: March 2023

AbstractCalcium in interstitial fluids is central to systemic physiology and a crucial ion pool for entry into cells through numerous plasma membrane channels. Its study has been limited by the lack of methods that allow monitoring in tight inter-cell spaces at high spatio-temporal resolution. We engineered high performance ultra-low affinity genetically encoded calcium biosensors named GreenT-ECs. GreenT-ECs combine large fluorescence changes upon calcium binding and binding affinities (KD) ranging from 0.8 mM to 2.9 mM, making them uniquely tuned to calcium concentrations in extracellular organismal fluids. We validated GreenT-ECs in rodent hippocampal neurons and transgenic zebrafishin vivo, where the sensors enabled monitoring homeostatic regulation of tissue interstitial calcium. GreenT-ECs may become useful for recording very large calcium transients and for imaging calcium homeostasis in inter-cell structures in live tissues and organisms.
An intracellular phosphorus-starvation signal activates the PhoB/PhoR two-component system inSalmonella enterica
Authors: Bruna Roberto E. , Kendra Christopher G. , Pontes Mauricio H. 
Published: March 2023

AbstractBacteria acquire P primarily as inorganic orthophosphate (Pi, PO43-). Once internalized, Pi is rapidly assimilated into biomass during the synthesis of ATP. Because Pi is essential, but excessive ATP is toxic, the acquisition of environmental Pi is tightly regulated. In the bacteriumSalmonella enterica(Salmonella), growth in Pi-limiting environments activates the membrane sensor histidine kinase PhoR, leading to the phosphorylation of its cognate transcriptional regulator PhoB and subsequent transcription of genes involved in adaptations to low Pi. Pi limitation is thought to promote PhoR kinase activity by altering the conformation of a membrane signaling complex comprised by PhoR, the multicomponent Pi transporter system PstSACB and the regulatory protein PhoU. However, the identity of the low Pi signal and how it controls PhoR activity remain unknown. Here we characterize the PhoB-dependent and independent transcriptional changes elicited bySalmonellain response to P starvation, and identify PhoB-independent genes that are required for the utilization of several organic-P sources. We use this knowledge to identify the cellular compartment where the PhoR signaling complex senses the Pi-limiting signal. We demonstrate that the PhoB and PhoR signal transduction proteins can be maintained in an inactive state even whenSalmonellais grown in media lacking Pi. Our results establish that PhoR activity is controlled by an intracellular signal resulting from P insufficiency.
Pubertal growth spurt is not universal: Polymorphism in growth at adolescence and its possible origin
Authors: Henneberg Maciej , Rosset Iwona , Żądzińska Elżbieta 
Published: March 2023

AbstractObjectivesNumerous studies of child growth conducted in industrialised countries showed presence of the phenomenon of the adolescent growth spurt to the extent that its presence became a dogma applied to humans as a species. However, earliest observations of growth at adolescence and also observations of adolescent growth conducted in small traditional societies do not show pubertal spurts consistently. Longitudinal observations of growth of individuals in present-day societies show strong polymorphism of the age at which puberty starts and ends and the magnitude of growth acceleration during puberty. Some normally developing individuals may not experience the pubertal growth spurt.Design, Seeting, ParticipantsLongitudinal height growth data of 110 girls aged 6-18 years from homogenous socio-economic situation – one medical high school (=nursing college) in one large Polish city of Lodz.Results18 (16%) girls did not show statistically significant acceleration of body height growth while they reached the same adult height as their spurting peers. Girls who experienced growth spurt had the age at peak height velocity of 11.2 years and peak height velocity of 69.3 mm, comparable to those found in many other studies. There was a negative correlation of adult height with variation of individual accelerations (r-0.24, p=0.01) – girls whose accelerations differed less from year to year achieved greater adult heights.ConclusionsFindings of no pubertal spurts in some individuals have been made in other samples studied by other authors, though rarely reported. It can be argued that slow growth at adolescence was more favourable in conditions of limited access to nutrition and medical care while polymorphisms determining fast, uneven growth became more prevalent after industrialisation that, together with progress in health sciences, relaxed natural selection on patterns of growth. Individuals who do not experience pubertal growth spurts, but are otherwise healthy, should not be subject to clinical interventions.Summary BoxWhat is already known on this topicPubertal growth spurt in body height is considered a typical feature of postnatal development. There is a large polymorphism of the age at which the spurt occurs and of its intensity.Individuals who do not experience the spurt, but are otherwise healthy, may be subject to uncesessary clinical interventions.What this study addsAmong 110 female students of an urban secondary nursing college studied longitudinally from 6 to 16 years, 16% did not experience acceleration of growth at puberty.Similar findings were reported in the literature from some non-Westernised communities and from European 19thcentury populations.
Ferroptosis propagates to neighboring cells via cell-cell contacts
Authors: Roeck Bernhard F. , Vorndran Michael R. H. , Garcia-Saez Ana J. 
Published: March 2023

AbstractFerroptosis is an iron-dependent form of regulated cell death characterized by accumulation of peroxidized lipids and plasma membrane disruption, whose molecular mechanism of execution remains poorly understood. Here, we developed a new optogenetic system, Opto-GPX4Deg, for light-induced degradation of the lipid reducing protein GPX4, which allows controlled ferroptosis induction with high precision in time and space. By using Opto-GPX4Deg to study cell death dynamics within the cellular population, we found that lipid peroxidation, followed by ferroptotic death, spread to neighboring cells in a distance-dependent manner. Remarkably, ferroptosis propagation showed a strong dependency on cell confluence and preferentially affected adjacent cells. Our findings establish cell death propagation as a feature of ferroptosis and provide new understanding of the mechanism involved.
Flight data-driven intelligent prediction for fuselage vibration of helicopter
Authors: Deng Jinghui , Cheng Qiyou , Lu Xing 
Published: March 2023

Purpose
Helicopter fuselage vibration prediction is important to keep a safety and comfortable flight process. The helicopter vibration mechanism model is difficult to meet of demand for accurate vibration prediction. Thus, the purpose of this paper is to develop an intelligent algorithm for accurate helicopter fuselage vibration analysis.

Design/methodology/approach
In this research, a novel weighted variational mode decomposition (VMD)- extreme gradient boosting (xgboost) helicopter fuselage vibration prediction model is proposed. The vibration data is decomposed and reconstructed by the signal clustering results. The vibration response is predicted by xgboost algorithm based on the reconstructed data. The information transfer order between the controllable flight data and flight attitude are analyzed.

Findings
The mean absolute percentage error (MAPE), root mean square error (RMSE) and mean absolute error (MAE) of the proposed weighted VMD-xgboost model are decreased by 6.8%, 31.5% and 32.8% compared with xgboost model. The established weighted VMD-xgboost model has the highest prediction accuracy with the lowest mean MAPE, RMSE and MAE of 4.54%, 0.0162, and 0.0131, respectively. The attitude of horizontal tail and cycle pitch are the key factors to vibration.

Originality/value
A novel weighted VMD-xgboost intelligent prediction methods is proposed. The prediction effect of xgboost model is highly improved by using the signal-weighted reconstruction technique. In addition, the data set used is collected from actual helicopter flight process.
Participative leadership effects on followers' radical creativity: role of creative process engagement and supervisor support for creativity
Authors: Nabi Md. Nurun , Akter Mst. Marium 
Published: March 2023

PurposeDrawn on self-determination (SDT) and social cognitive theory (SCT), this study examines how participative leadership (PL) influences the creative process engagement of followers (CPE) on fostering followers' radical creativity (FRC) through the supervisor support for creativity (SSC). It also demonstrates the CPE as a cognitive mediator between PL and FRC and SSC as a behavioral moderator between PL and CPE in Asia's manufacturing settings.Design/methodology/approachThe research is quantitative, and data are gathered using a questionnaire and a survey of Bangladesh's 252 textile and apparel industry respondents. SPSS 26 and SMART PLS 3.8 evaluated the measurement and structural models and other descriptive analyses for hypothesis testing and result confirmation.FindingsThe findings revealed that PL positively impacted followers' creative process engagement. Again, the CPE of followers was used to mediate PL and FRC to promote and determine radical creativity. Moreover, the research also found a substantial correlation between PL and the creative process involved in supervisor support for creativity, which increases followers' radical creativity.Research limitations/implicationsThis study contributes to the current literature by extending the scope of PL, CPE, FRC, SDT and SCT theory incorporating supervisor support.Practical implicationsThe findings showed that textile and apparel industry managers, leaders and practitioners could use participatory leadership to engage in collaborative leader-follower creativity goal setting, creativity-relevant thinking and talent flourishing to encourage and motivate creativity through supervisor support to followers to foster radical creativity.Originality/valueThe results demonstrate the colloquial expression in behavioral mechanism (creative process engagement) nurtured with the cognitive tool, shedding insight into the link between PL and radical creativity in followers (SSC for promoting radical creativity).
An exploration of the causal structure underlying crowdfunding: theoretical findings and practical implications
Authors: Linzalone Roberto , Ammirato Salvatore , Felicetti Alberto Michele 
Published: March 2023

PurposeCrowdfunding (CF) is a digital-financial innovation that, bypassing credit crisis, bank system rigidities and constraints of the capital market, is allowing new ventures and established companies to get the needed funds to support innovations. After one decade of research, mainly focused on relations between variables and outcomes of the CF campaign, the literature shows methodological lacks about the study of its overall behavior. These reflect into a weak theoretical understanding and inconsistent managerial guidance, leading to a 27% success ratio of campaigns. To bridge this gap, this paper embraces a “complex system” perspective of the CF campaign, able to explore the system's behavior of a campaign over time, in light of its causal loop structure.Design/methodology/approachBy adopting and following the document model building (DMB) methodology, a set of 26 variables and mutual causal relations modeled the system “Crowdfunding campaign” and a data set based on them and crafted to model the “Crowdfunding campaign” with a causal loop diagram. Finally, system archetypes have been used to link the causal loop structure with qualitative trends of CF's behavior (i.e. the raised capital over time).FindingsThe research brought to 26 variables making the system a “Crowdfunding campaign.” The variables influence each other, thus showing a set of feedback loops, whose structure determines the behavior of the CF campaign. The causal loop structure is traced back to three system archetypes, presiding the behavior in three stages of the campaign.Originality/valueThe value of this paper is both methodological and theoretical. First, the DMB methodology has been expanded and reinforced concerning previous applications; second, we carried out a causation analysis, unlike the common correlation analysis; further, we created a theoretical model of a “Crowdfunding Campaign” unlike the common empirical models built on CF platform's data.
Influence of wind and rain environment on operational safety of intercity train running on the viaduct
Authors: Zeng Guang-Zhi , Li Zhi-Wei , Huang Sha , Chen Zheng-Wei 
Published: March 2023

Purpose
Based on the aerodynamic loads and dynamic performances of trains, this study aims to investigate the effect of crosswinds and raindrops on intercity trains operating on viaducts to ensure the safe operation of intercity railways in metropolitan areas.

Design/methodology/approach
An approach coupled with the Euler multiphase model as well as the standard k-ɛ turbulence model is used to investigate the coupled flow feature surrounding trains and viaducts, including airflow and raindrops, and the numerical results are validated with those of the wind tunnel test. Additionally, the train’s dynamic response and the operating safety region in different crosswind speeds and rainfall is investigated based on train’s aerodynamic loads and the train wheel–rail dynamics simulation.

Findings
The aerodynamic loads of trains at varying running speeds exhibit an increasing trend as the increase of wind speed and rainfall intensity. The motion of raindrop particles demonstrates a significant similarity with the airflow in wind and rain environments, as a result of the dominance of airflow and the supplementary impacts of droplets. As the train’s operating speed ranged between 120 and 200 km/h and within a rainfall range of 20–100 mm/h, the safe operating region of trains decreased by 0.56%–7.03%, compared with the no-rain condition (0 mm/h).

Originality/value
The impact of crosswind speeds and rainfall on the train’s aerodynamic safety is studied, including the flow feature of crosswind and different particle-sized raindrops around the train and viaduct, aerodynamic loads coefficients suffered by the intercity train as well as the operating safety region of intercity trains on the viaduct.
Internet gaming addiction – a bibliometric review
Authors: Gupta Kirti , Kumar Chanakya , Deshpande Amruta , Mittal Amit , Chopade Pallavi , Raut Rajesh 
Published: March 2023

Purpose
The purpose of the study is to analyze a sample of 528 published papers over the past 11 years by conducting a bibliometric analysis. The study also aims to provide a consolidated overview of the existing literature on “gaming addiction” and presents the status of research with future directions for researchers who wish to explore and contribute to this rapidly evolving field. The descriptive statistics have been conducted through citation and co-citation analysis.

Design/methodology/approach
For the bibliometric analysis, the documents were retrieved from the Scopus database with the help of the Scopus analyzer while the VOS viewer1.6.16 software was used to analyze citations, co-authorship, etc. The literature search strategy was applied across various databases and the articles published between 2010 and December 2021 giving a total of 1,219 articles across all disciplines. Finally, 528 articles were shortlisted through the query restricted to subject areas, namely, business management, psychology, social science and multidisciplinary areas.

Findings
IGA has also been recognized by the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, as one of the disorders; hence, this certainly calls for focussed efforts to understand the same and control further damage. The number of articles devoted to the study of “gaming addiction” has increased rapidly in recent years. Moreover, this study identifies some of the most influential articles in this area. Finally, this paper highlights the new trends and discusses the future research associated with gaming addiction.

Research limitations/implications
This study focusses on gaming addiction and its trends, related to researchers and country-wise contributions. This is one of the few studies to review the literature on gaming addiction by using citation and co-citation analysis. The main findings of this paper will help academicians and practitioners to improve the body of knowledge on the topic and provide an overview of promising future research avenues.

Originality/value
Internet gaming is a newly emerging area and studies related to gaming addiction are very recent. To the best of the authors’ knowledge, this study is a unique and comprehensive overview of the leading works done in this area.
Comovements and hedging effectiveness between conventional and Islamic cryptocurrencies: evidence from the COVID-19 pandemic
Authors: Ali Shoaib , Yousaf Imran , Vo Xuan Vinh 
Published: March 2023

PurposeThis study examines the dynamics of the comovement and causal relationship between conventional (Bitcoin, Ethereum and Binance coin) and Islamic (OneGram, X8X token and HelloGold) cryptocurrencies.Design/methodology/approachThis study uses wavelet coherence approach to examine the time-varying lead-lag relationship between conventional and Islamic cryptocurrencies. Furthermore, the authors use BEKK-GARCH model to estimate the optimal weights, hedge ratio and hedging effectiveness in pre-COVID-19 and during the COVID-19 period.FindingsThe authors find no significant comovement in pre-COVID-19. However, the authors find significant positive comovement in conventional and Islamic cryptocurrencies at the beginning of the pandemic, and in most cases, conventional cryptocurrencies are leading. X8X and HelloGold have no/weak correlation with conventional cryptocurrencies, implying that investors can diversify the risk by making an Islamic and conventional cryptocurrencies portfolio. The authors also calculate the optimal weights, hedge ratio and hedging effectiveness using the BEKK-GARCH model. Based on the optimal weights, for the portfolios of conventional–Islamic cryptocurrencies, investors are suggested to increase their investment in Islamic cryptocurrencies during the COVID-19 than normal period. The results of hedge ratios show that hedging costs are higher during COVID-19 than before.Practical implicationsThe findings of the paper offer several practical policy implications for investors, portfolio manager, Shariah advisors and policymakers pertaining to asset allocation, risk management, forecasting and diversification. Specifically, investors can maximize the risk adjusted returns of their conventional cryptocurrencies portfolio by adding some portions of Islamic cryptocurrencies. Considering the comovement is time-varying, investors/manager should adjust their investment strategies frequently. For the entrepreneurs in crypto-industry, it is advised to introduce new Islamic cryptocurrencies, as it has a huge growth potential because of their distinct features and performance.Originality/valueThis is the first study that explores the linkages between conventional and Islamic cryptocurrencies, therefore this study extends the literature of Islamic finance, stablecoins and cryptocurrencies in pre-COVID-19 and during COVID-19 period. The study results provide insights to conventional crypto investor on how to manage their portfolio during normal and turbulent period.