bluuebunny/crossref_metadata_2025_split huggingface dataset:
Degradasi Otoritas KUA sebagai Lembaga Pencatatan Perkawinan Pasca Berlakunya SPTJM dalam Permendagri No. 9 Tahun 2016
Authors: Alifianti Salsa Devi Sisti , Izzah Amelia Nurul , Zudin Muhammad Fhaiz Habib Fhaizin , Gunawan Arfiyanto , Ulya Zakiyatul 
Published: July 2023

Pemberlakuan SPTJM atau Surat Pertanggung Jawaban Mutlak kebenaran sebagai suami isteri merupakan hasil dari lahirnya Peraturan Menteri Dalam Negeri No. 9 Tahun 2016. Peraturan ini dinilai bukan sebagai suatu penyelesaian dalam percepatan pembuatan akta kelahiran bagi masyarakat Indonesia. Penelitian ini bertujuan untuk mengetahui problematika akibat lahirnya permendagri No. 9 Tahun 2016 sehingga dapat melemahkan otoritas kewenangan Kantor Urusan Agama (KUA) sebagai lembaga pencatatan pernikahan. Dengan menggunakan metode penelitian berdasarkan studi kepustakaan, dengan riset pada Undang-Undang Perkawinan dan Peraturan Menteri Agama serta literatur yang terkait, ditemukan hasil bahwa SPTJM menimbulkan permasalahan krusial, yaitu membuka ruang untuk pernikahan siri, melawan Undang-Undang Perkawinan dan terutama melemahkan otoritas kewenangan KUA. KUA tidak dapat tidak dapat memproses pencatatan perkawinan dari hasil produk Permendagri berupa Kartu Keluarga bertuliskan “Kawin Belum Tercatat” yang diterbitkan oleh Dinas Pendudukan dan Catatan Sipil. Disisi lain, belum ada trobosan penyelesaian yang diupayakan oleh pembuat kebijakan, setelah mengkaji dalam Undang-Undang Peradilan Agama ternyata memberikan penyelesaian melalui Isbat Nikah.
Metode Ijtihad Kolektif Progresif di Indonesia Sebagai Media Proyeksi Nalar Kemanusiaan
Authors: Hadi Mukhammad Nur 
Published: July 2023

This study photographed the ijtihad method of two organizations Rumah KitaB Bersama (Rumah KitaB) and the Indonesian Women Ulema Congress (KUPI). The two points examined are the framework of the ijtihad method and the extent to which it can advocate for the rights of women and children. This study is a normative study by utilizing conceptual and philosophical approaches. Rumah KitaB and KUPI have a basic ushuliyyah approach, but differ in the construction of the paradigm and framework of ijtihad. The House of Book makes maqashid al-Islam a medium of dialogue between text and context. When linked to maqashid al-Islam, the text should be read with a critical paradigm while context with a spiritual paradigm. Then, the relationship of text and context should be read with a framework of alignments. Meanwhile, KUPI makes the rules of ushuliyyah and fiqhiyyah as methods elaborated with maqashid ash-sharia and Islamic universal values, such as humanity, justice, equality, interconnectedness, kindness, benefit, nationality, and universality. The main approaches used are mubadalah, makruf, and ultimate justice. This article finds that the ijtihad framework both contribute significantly to the strengthening of women's rights. It proves that both have created a new current of progressive, responsive, and inclusive collective ijtihad methods in Indonesia without having to abandon the classical texts. In fact, they have fought against Indonesia's established collective ijtihad framework but tend to be less responsive to marginal issues.
Application of Machine Learning in Predicting the Fatigue behaviour of Materials Using Deep Learning
Authors: Negi Pankaj 
Published: July 2023

Accurate prediction of the fatigue behaviour of materials is crucial for ensuring the reliability and durability of structural components in various engineering applications. Machine learning (ML) techniques have demonstrated significant potential in predicting fatigue behaviour by analysing complex datasets. This research paper explores the application of deep learning, a subset of ML, for predicting the fatigue behaviour of materials. The study focuses on the development and optimization of deep learning models to accurately predict fatigue life and failure modes based on material properties, loading conditions, and other relevant factors. The research aims to improve the understanding and prediction of fatigue behaviour, leading to enhanced design and optimization of materials and structures.
The prediction of fatigue behaviour in materials is a critical aspect in engineering design and structural integrity assessment. Traditional approaches rely on empirical models and physical testing, which can be time-consuming and resource-intensive. In recent years, the application of machine learning, particularly deep learning techniques, has shown promising results in predicting the fatigue behaviour of materials. This paper presents an analysis of the application of machine learning, specifically deep learning, in predicting the fatigue behaviour of materials. The study focuses on the use of deep learning models, such as convolutional neural networks (CNNs) and recurrent neural networks (RNNs), to analyse the complex relationships between material properties, loading conditions, and fatigue life. The paper discusses the methodology for training and validating the deep learning models using available fatigue data sets. Furthermore, it examines the performance and accuracy of the models in predicting fatigue life compared to traditional approaches. The findings suggest that deep learning models can effectively capture the nonlinear and intricate patterns in fatigue data, leading to accurate predictions of fatigue life. The practical implications of integrating machine learning into fatigue prediction are discussed, including the potential for accelerated design optimization, reduced testing requirements, and enhanced structural reliability. The contribution of this study lies in the exploration and evaluation of deep learning techniques for predicting the fatigue behaviour of materials, providing insights into the capabilities and limitations of machine learning approaches in this domain. Machine learning, particularly deep learning, as a valuable tool in predicting the fatigue behaviour of materials, enabling more efficient and reliable engineering design processes.
Optimization of Convergence of Mixed Finite Element Approximations Analysis
Authors: Srivastava Neeraj 
Published: July 2023

The numerical approximation of partial differential equations (PDEs) plays a vital role in many scientific and engineering applications. Mixed finite element methods have emerged as powerful techniques for solving a wide range of PDEs due to their ability to handle problems with mixed variables, such as fluid flow and elasticity. However, ensuring the convergence of mixed finite element approximations remains a challenging task. It presents a comprehensive analysis of the optimization strategies employed to enhance the convergence of mixed finite element approximations. We investigate the key factors that impact the convergence behaviour of these methods and propose various techniques to mitigate convergence issues. we discuss the importance of appropriate discretization strategies for mixed finite element approximations. We analyze the impact of element types, mesh refinement, and stabilization techniques on the convergence rates. By examining the properties of the underlying mixed variational formulations, we identify the optimal discretization choices that lead to improved convergence behaviour. We delve into the analysis of numerical stability and consistency in the context of mixed finite element methods. We explore the role of stabilization techniques, such as bubble functions and penalty terms, in mitigating instabilities and achieving optimal convergence rates. We investigate the effect of different stabilization parameters and establish guidelines for their selection to ensure both stability and convergence. We address the issue of error estimation and adaptivity in mixed finite element approximations. We review error indicators and adaptive mesh refinement strategies that enable the refinement of regions with high solution gradients, thus enhancing the convergence rates. We discuss the interplay between error estimation and adaptive refinement and present numerical examples illustrating their effectiveness.
We highlight recent advancements in optimization algorithms specifically tailored for enhancing convergence in mixed finite element approximations. We explore strategies like multigrid methods, preconditioning techniques, and domain decomposition methods, which accelerate the convergence rates and enable the solution of large-scale problems. This paper provides a comprehensive analysis of the optimization of convergence for mixed finite element approximations. It serves as a valuable resource for researchers and practitioners seeking to improve the efficiency and accuracy of numerical solutions obtained through mixed finite element methods.
Early initiation of anti-relapse antiarrhythmic therapy in patients with atrial fibrillation and flutter after pharmacological cardioversion with refralon
Authors: Gagloeva D. A. , Dzaurova Kh. M. , Zelberg M. A. , Mironov N. Yu. , Yuricheva Yu. A. , Sokolov S. F. , Golitsyn S. P. 
Published: July 2023

Aim Evaluating the efficacy and safety of early administration of antirecurrence antiarrhythmic therapy (AAT) following restoration of sinus rhythm (SR) with refralon.Aim Evaluating the efficacy and safety of early administration of antirecurrence antiarrhythmic therapy (AAT) following restoration of sinus rhythm (SR) with refralon.Material and methods The study included 247 patients with atrial fibrillation/atrial flutter (AF/AFL) (142 men) who underwent pharmacological cardioversion (PCV) with refralon. A 4-step schedule of drug administration was used (successive intravenous infusions at doses of 5, 5, 10, and 10 µg/kg; maximum total dose was 30 µg/kg). Patients who recovered SR and had no contraindications were prescribed antirecurrence AAT in the early (≤24 h; n=101) or delayed (≥24 h; n=95) period. Lappaconitine hydrobromide, propafenone, and sotalol were administered orally as the antirecurrence therapy. The decision on the time of initiating ATT and the choice of the drug and its dose was taken by the attending physician individually. The safety criteria included a prolonged PQ interval >200 ms; second- or third-degree atrioventricular block; QRS complex duration >120 ms; QT prolongation >500 ms; and heartbeat pauses >3 s. The efficacy criteria included the absence of sustained recurrence of AF/AFL after initiation of AAT and the duration of hospitalization after PCV. Patients were followed up during the study until they were discharged from the hospital.Results SR was recovered in 229 (92.7 %) patients. In the group of early AAT initiation, a PQ duration >200 ms was observed in 8 (7.9 %) patients, whereas in the group of delayed AAT initiation, in 7 patients (7.4 %; p=1.000). A wide QRS complex >120 ms was recorded in 1 (1.1 %) patient of the delayed AAT initiation group and in none of the patients of the early AAT initiation group (p=0.485). Ventricular arrhythmogenic effects and QT prolongation >500 ms were not detected in any patient. Numbers of early AF recurrence did not differ in the groups of early and delayed AAT initiation: 6 (5.9 %) vs. 5 (5.3 %), respectively (p=1.000). Median duration of hospitalization after PCV was 4 days in the group of early AAT initiation and 5 days in the group of delayed AAT initiation (р=0.009).Conclusion Early initiation of the refralon AAT does not increase the risk of drug adverse effects and reduces the duration of stay in the hospital.
C<sub>2</sub>HEST and CHA<sub>2</sub>DS<sub>2</sub>-Vasc for predicting recurrence after catheter ablation of paroxysmal atrial fibrillation
Authors: Özmen Gökhan , Koca Fatih 
Published: July 2023

Aim The C2HEST score was developed mainly for predicting atrial fibrillation (AF) in cryptogenic stroke. This study investigated the performance of the C2HEST score in predicting AF recurrence after radiofrequency catheter ablation (RFCA).Material and Methods 189 patients with paroxysmal AF were included in the study. AF recurrence and AF-free survival during follow-up was analyzed. The Cox proportional-hazards model was used to identify independent predictors of AF recurrence after RFCA. Receiver operating characteristic curve analysis and the Hanley and McNeil method were performed to evaluate the performances of the C2HEST and CHA2DS2-VASc scores in predicting AF. AF-free periods of the with C2HEST<2 and C2HEST >2 were compared using Kaplan-Mayer analysis and a log-rank test.Results The AF recurrence rate within 3–12 months after RFCA was 17.5%. C2HEST score >2, hypertension, left atrial (LA) diameter, and LA volume were independent predictors for AF recurrence (p<0.05). The C2HEST score had better discriminatory performance in predicting AF recurrence than CHA2DS2-VASc (area under curve: 0.769 vs 0.644; p=0.021). The patients with a C2HEST score >2 had a significantly shorter AF-free period compared those with a C2HEST SCORE <2 (p<0.001).Conclusion In patients who underwent a RFCA procedure due paroxysmal AF, LA diameter and volume and the C2HEST score were independent predictors of AF recurrence. C2HEST is a simple clinical score, and it can be the readily performed to identify the risk of AF recurrence. The C2HEST score has greater diagnostic power than the CHA2DS2-VASc score.
Left lateral decubitus computed tomography before catheter ablation in patients with atrial fibrillation
Authors: Kaliyev Bauyrzhan Bakhytovich , Rakhimzhanova Raushan Ibzhanovna , Sinitsyn Valentin Evgenyevich , Dautov Tairkhan Bekpolatovich , Abdrakhmanov Ayan Suleimenovich 
Published: July 2023

Aim The study aimed to determine the efficacy of cardiac computed tomography angiography (CCTA) for diagnosing left atrial appendage (LAA) thrombus before catheter ablation with the patient in the left lateral decubitus position and, also, to evaluate the risk factors for thrombus formation.Material and methods This retrospective, cohort study included 101 patients with atrial fibrillation. All patients underwent transthoracic echocardiography (TTE) and left lateral decubitus CCTA. Transesophageal echocardiography (TEE) was performed to confirm or exclude LAA thrombus. Patients with allergic reactions to iodinated contrast media, increased serum creatinine, hyperthyroidism, pregnancy, and age<18 years were excluded. The CHA2‑DS2‑VASc and HAS-BLED scores were calculated for each patient.Results All LAA thrombi detected on CCTA were confirmed by TEE. Higher CHA2‑DS2‑VASc, HAS-BLED scores, enlarged LA, and the anteroposterior dimension of the left atrium were significantly associated with the presence of LAA thrombus. A LAA cauliflower shape was a predictor of thrombus. An increase of LAA volume by 1 ml increased the chances of LAA thrombus and cerebral ischemic infarct by 2 %. The growth of the LAA anteroposterior diameter by 1 cm increased the risk of LAA thrombus by 190 % and of cerebral infarct by 78 %. An increase in the CHA2DS2‑VASc score by 1 point increased the risk of thromboembolism and cerebral infarction by 12 %.Conclusions CCTA performed in the left lateral decubitus position of the patient is an optimal screening tool to detect or exclude LAA thrombus before catheter ablation because of atrial fibrillation. CCTA has predictive value for risk of thrombosis formation in LAA.
Phylogenetic and Pathogenicity Comparison of Three H5N6 Avian Influenza Viruses in Chickens, Ducks and Mice
Authors: Zhang rui , chen Zhen , Liu Rong chang , Fu Guang hua , Liu Bin qiong , Shi Shao hua , Cai Guo zhang , Huang Yu , Liao Ming 
Published: July 2023

Abstract
Background
H5N6 subtype avian influenza virus (AIV) continues to erupt in poultry, and it also threatens human public health safety. The goal is to clarify the evolutionary characteristics of the 3 strains of H5N6 subtype AIV and the variation of special amino acid sites, and to clarify the pathogenic characteristics of the virus to chickens, ducks and mice.3 strains of H5N6 subtype AIV named as A/ Environment/ Fujian/ ENIVER109/ 2020 (H5N6) , A/ Duck/ Fujian/ DK039/ 2020 (H5N6) , A/ Duck/ Fujian/ DK153/ 2020 (H5N6) . The genetic evolution and variation of the 3 viruses were analyzed by whole genome sequencing. Chickens, ducks and mice were infected with 3 strains of viruses through the nasal cavity, and the pathogenic ability and pathogenic characteristics of the viruses to different animals were observed.
Results
​The HA genes of all three viruses are in the 2.3.4.4h clade. The ancestor of the DK039 strain may have been different from the other two viruses. Mutations with cross-species transmission and enhanced pathogenicity were found in all three viruses. Infected chickens, ducks and mice showed differences in body weight, clinical signs, apparent and microscopic lesions in organs, and viral titers in organs.
Conclusions
​The isolated H5N6 subtype AIV has many mutations associated with pathogenicity and cross-host transmission, and the pathogenicity of the virus varies from animal to animal.
Bone Mineral Density is positively associated with risk of All-Cause and Cardiovascular Mortality among Adults with Type 2 Diabetes Mellitus:a cross-sectional study of the NHANES 2005-2010,2013-2014
Authors: wang baolong , Xu Dongshuo , Zhang Jialu , cao Shiyu , Ye Jingya , Yu Zhuo , wang changhui 
Published: July 2023

Abstract
Background
With aging and lifestyle changes, the coexistence of osteoporosis and T2DM is becoming more and more common, which greatly improves the disability and mortality of patients.However, the associations of reduced BMD value with CVD and all-cause mortality in patients with T2DM have not been conclusively established.
Methods
Using the National Health and Nutrition Examination Survey (NHANES), a nationally representative sample of the U.S. population,we aim to estimate the association of bone mineral density with the risk of CVD mortality and all-cause mortality in US adults with T2DM.
Results
We demonstrated that increased bone mineral density was significantly positively related to decreased mortality from all causes and cardiovascular diseases among US adults with T2DM.Meanwhile,we found that, after multivariate adjustment, osteoporosis and osteopenia were independently associated with an increased risk of all-cause and CVD mortality in T2DM patients at long-term follow-up.In terms of CVD mortality,stratified analyses suggested that these associations were stronger in participants who had a wider waist and higher total triglyceride,and the relationships in other stratified were mostly consistent with the total T2DM patients.In addition,a variety of sensitivity analyses indicated the robustness of our findings.
Conclusions
T2DM patients with low BMD value should be aware of the potential risk of cardiovascular disease and mortality, and carry out secondary prevention of osteoporosis and osteopenia as early as possible.
Assessing the Impact of a Student-Led Public Health Campaign on HIV Knowledge and Awareness: A Case Series Study
Authors: Rocha Paula , Freitas Giulia C. , Bueno Rafaela M. 
Published: July 2023

Abstract
Background:
The global effort to end AIDS as a public health threat by 2030 has prompted various initiatives. A student-led public health campaign was conducted by Brazilian medical students from Pontifícia Universidade Católica de Campinas (PUC Campinas) in 2015, 2018, and 2023. The campaign inspired local leadership, innovation, and partnership in the fight against HIV/AIDS. This study evaluates the impact of the campaign on raising awareness about HIV/AIDS and assesses its effectiveness as a model for similar initiatives worldwide.
Methods:
The campaign was organized by medical students from PUC Campinas who were members of the International Federation of Medical Students Associations (IFMSA). It was developed iteratively over the years, with data collection and evaluation informing subsequent program modifications. The students received specialized training on HIV/AIDS prior to distributing relevant educational materials. On the final day of the campaign, students wore red ribbons or shirts and engaged in conversations with individuals in public settings such as parks, bus stations, and malls. Participants in the conversations were ultimately provided information on HIV/AIDS prevention, disease, and treatment, and their knowledge was assessed through pre- and post-campaign questionnaires.
Results:
Among the 3150 individuals approached during the campaigns, 78% had limited knowledge about HIV testing and AIDS symptoms. Following the campaign, 88% of participants considered their knowledge about rapid tests and AIDS symptoms to be satisfactory. These findings demonstrate the campaign's positive impact on improving awareness and understanding among participants.
Conclusion:
This study highlights the impact of a student-led public health campaign on HIV knowledge and awareness. The campaign effectively addressed the lack of information among both students and participants, resulting in improved knowledge about topics including rapid tests and AIDS symptoms. These findings underscore the importance of educational initiatives in healthcare training and provide insights for future curriculum development to enhance public health awareness and education.
Comprehensive analysis of 2097 Patients with Dystrophinopathy Based on a Database From 2011 to 2021
Authors: Zhao Lei , Shi Yiyun , Hu Chaoping , Zhou Shuizhen , Li Hui , Zhang Lifeng , Qian Chuang , Zhou Yiyao , Li Xihua 
Published: July 2023

Abstract

Background
A growing number of clinical trials for new therapeutic strategies are being conducted or considered for dystrophinopathy. Detailed data on natural history will facilitate the evaluation of the effectiveness of new drugs for this rare disease. Nevertheless, there is a paucity of data regarding the long-term natural history and associated management in China. Here, we provide a comprehensive description of associated clinical and molecular findings and treatment outcomes in the Chinese population.
Methods
Institutional data on all patients with dystrophinopathy from August 2011 to August 2021 were reviewed retrospectively. The data included geographic distribution, age at diagnosis, genetic analysis, and treatment such as corticosteroids, cardiac interventions, and clinical outcomes.
Results
In total, 2097 patients with dystrophinopathy, including 1703 Duchenne muscular dystrophy (DMD), 311 Becker muscular dystrophy (BMD), 46 intermediate muscular dystrophy (IMD), and 37 “pending” (individuals with an undetermined phenotype) were registered in the Children’s Hospital of Fudan University database for dystrophinopathy from August 2011 to August 2021. The spectrum of identified mutations included exon deletions (66.7%), exon duplications (10.7%), nonsense mutations (10.3%), splice-site mutations (4.5%), small deletions (3.5%), small insertions (1.8%), and missense mutations (0.9%). Two deep intronic mutations were identified. Regarding treatment, 54.4% of DMD patients and 39.1% of IMD patients were treated with glucocorticoids. The median age at loss of ambulation was 2.5 years later in DMD patients with glucocorticoid treatment. Overall, 7.4% of DMD, 8.3% of IMD, and 2.6% of BMD patients were prescribed one cardiac medicine at least, and four DMD patients were under ventilator support. Those eligible for exon skipping therapy included 55.3% of DMD patients; among them, 12.9%, 10%, and 9.6% of these patients were eligible for skipping exons 51, 53, and 45.
Conclusions
This is one of the largest studies to have evaluated the natural history of dystrophinopathy in China, which is particularly conducive to recruiting eligible patients for clinical trials and providing real-world data to support drug development.