bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of Medical and Public Assistance Expenditures and Employment Among US Adults With Cancer Diagnoses
Authors: Grabowski David C. , Kansal Anuraag R. , Goldman Dana P. , Lakdawalla Darius N. 
Published: May 2023

ImportancePrior research suggests significant social value associated with increased longevity due to preventing and treating cancer. Other social costs associated with cancer, such as unemployment, public medical spending, and public assistance, may also be sizable.ObjectiveTo examine whether a cancer history is associated with receipt of disability insurance, income, employment, and medical spending.Design, Setting, and ParticipantsThis cross-sectional study used data from the Medical Expenditure Panel Study (MEPS) (2010-2016) for a nationally representative sample of US adults aged 50 to 79 years. Data were analyzed from December 2021 to March 2023.ExposureCancer history.Main Outcomes and MeasuresThe main outcomes were employment, public assistance receipt, disability, and medical expenditures. Variables for race, ethnicity, and age were used as controls. A series of multivariate regression models were used to assess the immediate and 2-year association of a cancer history with disability, income, employment, and medical spending.ResultsOf 39 439 unique MEPS respondents included in the study, 52% were female, and the mean (SD) age was 61.44 (8.32) years; 12% of respondents had a history of cancer. Individuals with a cancer history who were aged 50 to 64 years were 9.80 (95% CI, 7.35-12.25) percentage points more likely to have a work-limiting disability and were 9.08 (95% CI, 6.22-11.94) percentage points less likely to be employed compared with individuals in the same age group without a history of cancer. Nationally, cancer accounted for 505 768 fewer employed individuals in the population aged 50 to 64 years. A cancer history was also associated with an increase of $2722 (95% CI, $2131-$3313) in medical spending, $6460 (95% CI, $5254-$7667) in public medical spending, and $515 (95% CI, $337-$692) in other public assistance spending.Conclusions and RelevanceIn this cross-sectional study, a history of cancer was associated with increased likelihood of disability, higher medical spending, and decreased likelihood of employment. These findings suggest there may be gains beyond increased longevity if cancer can be detected and treated earlier.
Biomechanical and Biological Characterization of XGel, a Human‐Derived Hydrogel for Stem Cell Expansion and Tissue Engineering
Authors: Belgodere Jorge A. , Lassiter Haley R. , Robinson Jordan T. , Hamel Katie M. , Rogers Emma L. , Mohiuddin Omair A. , Zhang Liwen , Wu Xiying , Gimble Jeffrey M. , Frazier Trivia P. , Monroe William T. , Sanchez Cecilia G. 
Published: May 2023

AbstractHydrogels are 3D scaffolds used as alternatives to in vivo models for disease modeling and delivery of cells and drugs. Existing hydrogel classifications include synthetic, recombinant, chemically defined, plant‐ or animal‐based, and tissue‐derived matrices. There is a need for materials that can support both human tissue modeling and clinically relevant applications requiring stiffness tunability. Human‐derived hydrogels are not only clinically relevant, but they also minimize the use of animal models for pre‐clinical studies. This study aims to characterize XGel, a new human‐derived hydrogel as an alternative to current murine‐derived and synthetic recombinant hydrogels that features unique physiochemical, biochemical, and biological properties that support adipocyte and bone differentiation. Rheology studies determine the viscosity, stiffness, and gelation features of XGel. Quantitative studies for quality control support consistency in the protein content between lots. Proteomics studies reveal that XGel is predominantly composed of extracellular matrix proteins, including fibrillin, collagens I–VI, and fibronectin. Electron microscopy of the hydrogel provides phenotypic characteristics in terms of porosity and fiber size. The hydrogel demonstrates biocompatibility as a coating material and as a 3D scaffold for the growth of multiple cell types. The results provide insight into the biological compatibility of this human‐derived hydrogel for tissue engineering.
Mechanochemical Post‐Synthesis of Metal–Organic Framework‐Based Pre‐Electrocatalysts with Surface FeONi/Co Bonding for Highly Efficient Oxygen Evolution
Authors: Zhang Wang , Niu Menghao , Yu Jing , Li Shiqi , Wang Yu , Zhou Kun 
Published: May 2023

AbstractRational surface engineering of metal–organic frameworks (MOFs) provide potential opportunities to address the sluggish kinetics of oxygen evolution reaction (OER). However, the development of MOF‐based materials with low overpotentials remains a great challenge. Herein, a post‐synthesis strategy to prepare highly efficient MOF‐based pre‐electrocatalysts via all‐solid‐phase mechanochemistry is demonstrated. The surface of a Fe‐based MOF (MIL‐53) can be reconstructed and anchored with atomically dispersed Ni/Co sites. As expected, the optimized M‐NiA‐CoN exhibits a very low overpotential of 180 mV at 10 mA cm−2 and a small Tafel slope of 41 mV dec−1 in 1 m KOH electrolyte. The superior electrocatalytic OER activity is mainly due to the formation of surface FeONi/Co bonding. Furthermore, density functional theory calculations reveal that the transformation from *OH to *O is the rate‐determining step and the electrocatalytic OER activity trend at different metal sites is Co > Ni≈Fe.
Nanoliter Liquid Packaging in a Bioresorbable Microsystem by Additive Manufacturing and its Application as a Controlled Drug Delivery Device
Authors: Park Jongeon , Bertsch Arnaud , Martin‐Olmos Cristina , Brugger Juergen 
Published: May 2023

AbstractPrecise packaging of nanoliter amounts of liquid in a microsystem is important for many biomedical applications. However, existing liquid encapsulation technologies have limitations in terms of liquid waste, evaporation, trapped bubbles, and liquid degradation. In this study, multiple additive manufacturing techniques for nanoliter liquid packaging in bioresorbable microsystems is used. Two‐photon photolithography is used for bioresorbable reservoir fabrication, while inkjet printing (IJP) is used for precise nanoliter liquid packaging. Dual IJP allows for micro‐reservoirs to be filled with precise amounts of drug solution and subsequently and rapidly sealed with a layer of lipids mixed with Fe3O4 nanoparticles. Combining these two printing techniques can overcome the previous limitations of liquid encapsulation technologies. To demonstrate the relevance of this technique, a wirelessly activated, bioresorbable multi‐reservoir microcapsule that can be used for controlled drug delivery is presented. The microcapsules and their content are shown to be stable during fabrication, storage, and operation. Multiple cargo release events are triggered independently by the local melting of the sealing layer, resulting from magnetically induced Fe3O4 nanoparticle heating. The operation of the capsule is demonstrated in tissue phantoms and in vitro cell cultures.
One‐Step Sintering Synthesis Achieving Multiple Structure Modulations for High‐Voltage LiCoO2
Authors: Ren Hengyu , Zhao Wenguang , Yi Haocong , Chen Zhefeng , Ji Haocheng , Jun Qi , Ding Wangyang , Li Zijian , Shang Mingjie , Fang Jianjun , Li Ke , Zhang Mingjian , Li Shunning , Zhao Qinghe , Pan Feng 
Published: May 2023

AbstractThe structure instability issues of the highly delithiated LiCoO2 have significantly hindered its high‐voltage applications (≥4.55 V vs Li/Li+). Herein, for the first time, multiple modifications of Li0.9Mg0.05CoO2 (L0.9M0.05CO) via a simple one‐step sintering synthesis are reported. A combination of the bulk Li/Co antisites, a Mg‐pillar enriched surface, and a thin MgO coating layer is achieved to maintain both the bulk and surface structural stability of L0.9M0.05CO upon cycling at an upper cut‐off voltage of 4.6 V. The bulk Li/Co antisites are discovered to enhance the H1‐3 phase evolution reversibility, the Mg pillars that substitute the Li sites effectively reinforces the surface structure, and the thin MgO coating layer can effectively prevent the cathode from severe side reactions. Benefiting from the reduced but reversible H1‐3 phase transition and the reinforced surface structure, L0.9M0.05CO shows an excellent cycle stability. This work provides a new structure modulation route for developing high‐voltage LiCoO2 cathodes.
Parkinson's Disease: Current Status, Diagnosis, and Treatment Using Nanomedicines
Authors: Hasan Ikram , Roy Shubham , Guo Bing , Chang Chunqi 
Published: May 2023

AbstractParkinson's disease (PD) is a chronic, and highly neurodegenerative disorder with complex pathological processes. The features for neuropathological identification of PD include α‐synuclein (α‐syn) protein aggregates, oxidative stress, metal ion dyshomeostasis, neurotransmitter deficiencies, and mitochondrial dysfunction. Currently, no definite treatment paradigm can completely cure PD patients, which is increasing globally over the past few decades. The existence of the blood‐brain barrier (BBB) restricts the conventional treatment processes and makes the therapeutic delivery to the brain a bit more challenging. Therefore, developing new useful medicines for improving brain distribution is vital to overcome BBB and helping the early diagnosis and treatment of PD. In this review, the current limitations of conventional drugs are highlighted and the development of new medicines to overcome such limitations is covered. This work will provide insight into the direction for designing novel efficient nanomedicines for the early diagnosis and treatment of PD.
A new T‐antigen negative HEK293 cell line with improved AAV productivity
Authors: Croissant Coralie , Armitano Joshua , Lazuech Bertrand , Švec Danijel , Pugin Cyril , Guesdon Anaïs , Bryan Louise , Castro Antonio , Neuhaus Léa , Fonti Giulia , Martinis Jacopo , Wurm Maria J. , Wurm Florian M. , Pino Paco 
Published: May 2023

AbstractViral vectors for gene therapy, such as recombinant adeno‐associated viruses, are produced in human embryonic kidney (HEK) 293 cells. However, the presence of the SV40 T‐antigen‐encoding CDS SV40GP6 and SV40GP7 in the HEK293T genome raises safety issues when these cells are used in manufacturing for clinical purposes. We developed a new T‐antigen‐negative HEK cell line from ExcellGene's proprietary HEKExpress,® using the CRISPR‐Cas9 strategy. We obtained a high number of clonally‐derived cell populations and all of them were demonstrated T‐antigen negative. Stability study and AAV production evaluation showed that the deletion of the T‐antigen‐encoding locus did not impact neither cell growth nor viability nor productivity. The resulting CMC‐compliant cell line, named HEKzeroT,® is able to produce high AAV titers, from small to large scale.
Culprit lesion plaque characterization and thrombus grading by high‐definition intravascular ultrasound in patients with ST‐segment elevation myocardial infarction
Authors: Groenland Frederik T. W. , Ziedses des Plantes Annemieke C. , Neleman Tara , Scoccia Alessandra , Ligthart Jurgen M. R. , Witberg Karen T. , Mahmoud Karim D. , Nuis Rutger‐Jan , den Dekker Wijnand K. , Wilschut Jeroen M. , Diletti Roberto , Zijlstra Felix , Van Mieghem Nicolas M. , Daemen Joost 
Published: May 2023

AbstractBackgroundDedicated prospective studies investigating high‐definition intravascular ultrasound (HD‐IVUS)‐guided primary percutaneous coronary intervention (PCI) are lacking. The aim of this study was to qualify and quantify culprit lesion plaque characteristics and thrombus using HD‐IVUS in patients presenting with ST‐segment elevation myocardial infarction (STEMI).MethodsThe SPECTRUM study is a prospective, single‐center, observational cohort study investigating the impact of HD‐IVUS‐guided primary PCI in 200 STEMI patients (NCT05007535). The first 100 study patients with a de novo culprit lesion and a per‐protocol mandated preintervention pullback directly after vessel wiring were subject to a predefined imaging analysis. Culprit lesion plaque characteristics and different thrombus types were assessed. An IVUS‐derived thrombus score, including a 1‐point adjudication for a long total thrombus length, long occlusive thrombus length, and large maximum thrombus angle, was developed to differentiate between low (0–1 points) and high (2–3 points) thrombus burden. Optimal cut‐off values were obtained using receiver operating characteristic curves.ResultsThe mean age was 63.5 (±12.1) years and 69 (69.0%) patients were male. The median culprit lesion length was 33.5 (22.8–38.9) mm. Plaque rupture and convex calcium were appreciated in 48 (48.0%) and 10 (10.0%) patients, respectively. Thrombus was observed in 91 (91.0%) patients (acute thrombus 3.3%; subacute thrombus 100.0%; organized thrombus 22.0%). High IVUS‐derived thrombus burden was present in 37/91 (40.7%) patients and was associated with higher rates of impaired final thrombolysis in myocardial infarction flow (grade 0–2) (27.0% vs. 1.9%, p < 0.001).ConclusionsHD‐IVUS in patients presenting with STEMI allows detailed culprit lesion plaque characterization and thrombus grading that may guide tailored PCI.
Phosphine‐Free Pincer Ruthenium‐Catalyzed α‐Alkylation of Ketones with Secondary Alcohols to form β‐Branched Ketones
Authors: Bhattacharyya Dipanjan , Adhikari Priyanka , Hazarika Nitumoni , Sarmah Bikash Kumar , Das Animesh 
Published: May 2023

AbstractHerein, an efficient and expedient method was developed for α‐alkylation of aromatic ketones with secondary alcohols to produce β‐disubstituted ketones using phosphine‐free pincer ruthenium complexes as the catalyst. Single α‐alkylated ketone is produced in high yields even in reactions where a mixture of products is possible. Interestingly, challenging substrates such as unsubstituted and nonhindered acetophenone compounds are effectively alkylated under the reaction conditions. The scope of the reaction can span with a verities of aliphatic, cyclic, and acyclic secondary alcohols. Functionalization of a cholesterol molecule is also possible under the reaction conditions. Substitution on cyclohexyl ring afforded products as a mixture of diastereoisomers, wherein the major isomer is found as 1,4‐cis conformation of the cyclohexyl ring. Origin of the cis stereoselectivity in the alkylation process was explored by DFT calculation study. Mechanistic studies reveal that the dehydrogenation of alcohols follows a proton shuttle‐type of TS, involvement of cross‐aldol condensation and borrowing hydrogen catalysis. Notably, this selective, catalytic C−C bond forming reaction proceeds with low catalyst load, catalytic amount of base under air and produces H2O as the only byproduct, making the process environmentally benign and atom efficient.
A Novel Strategy to Enable Effective Use of Dioxolane‐Based Electrolytes in Lithium‐Ion Batteries
Authors: Orbay Metin , Leistenschneider Desirée , Leibing Christian , Balducci Andrea 
Published: May 2023

AbstractIn this work we reported about the use of an electrolyte for lithium‐ion batteries (LIBs) based on mixtures of 1,3‐dioxolane (DOL) and 1,2,2‐tetraethoxyethane (TEG). We showed that the electrolyte 1 M LIFSI in TEG : DOL (2 : 3) displays good transport properties and high thermal stability. Graphite and lithium‐iron phosphate (LFP) electrodes used in combination with this electrolyte display high capacity, high efficiency, high‐capacity retention at higher C‐rates and high stability during prolonged charge‐discharge cycles carried in a broad range of temperatures (from −20 °C till 60 °C). Furthermore, SEI analysis was performed using XPS, FTIR spectroscopy and SEM to understand the morphology of the SEI generated by this electrolyte and analyse them comparatively with the state‐of‐the‐art. We additionally show that this electrolyte can be successfully utilized in lab‐scale LIBs, and that these devices display good capacity and stability over 100 cycles at various current densities. Results obtained in this study indicate that the use of mixtures of TEG‐DOL is an effective, unexpensive and easy to implement strategy for the utilization of DOL in LIBs.
Reduction Behavior of Anisyl‐substituted P‐Ferrocenyl Phospholes
Authors: Getfert Katharina , Roesler Fabian , Bruhn Clemens , Pietschnig Rudolf 
Published: May 2023

AbstractP‐Ferrocenylphospholes with differing substituents in α‐position have been synthesized and their identity and purity was confirmed using multinuclear NMR spectroscopy, MS, elemental analysis and single crystal X‐ray diffraction. Furthermore, the redox properties have been explored with electrochemical measurements. Transferring the reduction to a preparative scale using lithium leads to reductive P−C bond cleavage furnishing the corresponding phospholide which has been transformed to P‐tert‐butyl substituted phosphole. In addition to phospholide formation reductive demethoxylation with transformation of the anisyl substituent to its phenyl analog was observed. For comparison analogous reactions have been explored for the respective P‐phenylphospholes which show a different reactivity.
β‐Glucan produced by Lentinus edodes suppresses breast cancer progression via the inhibition of macrophage M2 polarization by integrating autophagy and inflammatory signals
Authors: Zhu Fukai , Zhang Qianru , Feng Jiexin , Zhang Xiuru , Li Tingting , Liu Shuwen , Chen Yanling , Li Xiumin , Wu Qici , Xue Yu , Alitongbieke Gulimiran , Pan Yutian 
Published: May 2023

AbstractBackgroundβ‐Glucan from Lentinus edodes (LNT), an edible mushroom, possesses strong anticancer activity. However, the therapeutic effects of LNT during the occurrence and progression of breast cancer and their underlying molecular mechanisms have not been elucidated.MethodsMouse mammary tumor virus‐polyoma middle tumor‐antigen (MMTV‐PyMT) transgenic mice were used as a breast cancer mouse model. Hematoxylin and eosin, immunohistochemical, and immunofluorescence staining were performed for histopathological analysis. Moreover, we developed an inflammatory cell model using tumor necrosis factor‐α (TNF‐α). Macrophage polarization was assessed using western blot analysis and immunofluorescence.ResultsOrphan nuclear receptor 77 (Nur77) and sequestosome‐1 (p62) were highly expressed and positively correlated with each other in breast cancer tissues. LNT significantly inhibited tumor growth, ameliorated inflammatory cell infiltration, and induced tumor cell apoptosis in PyMT transgenic mice. Moreover, LNT attenuated the ability of tumors to metastasize to lung tissue. Mechanistically, LNT treatment restrained macrophage polarization from M1 to M2 phenotype and promoted autophagic cell death by inhibiting Nur77 expression, AKT/mTOR signaling, and inflammatory signals in breast tumor cells. However, LNT did not exhibit a direct pro‐autophagic effect on tumor cell death, except for its inhibitory effect on Nur77 expression. LNT‐mediated autophagic tumor cell death depends on M1 macrophage polarization. In in vitro experiments, LNT inhibited the upregulation of p62, autophagy activation, and inflammatory signaling pathways in Nur77 cells.ConclusionLNT inhibited macrophage M2 polarization and subsequently blocked the AKT/mTOR and inflammatory signaling axes in breast cancer cells, thereby promoting autophagic tumor cell death. Thus, LNT may be a promising therapeutic strategy for breast cancer.
Trends in obstetric anal sphincter injury in spontaneous vaginal delivery versus operative vaginal delivery over a 10‐year period: Lessons learned
Authors: Alkharouf Feras , Joyce Niamh , Ward Deidre , Walsh Fiona , Eogan Maeve , Geary Michael 
Published: May 2023

AbstractObjectiveTo evaluate trends in the incidence of women with obstetric anal sphincter injuries (OASIS) over a 10‐year period comparing spontaneous vaginal delivery (SVD) and operative vaginal delivery (OVD).MethodsA retrospective study was performed in which all women who underwent vaginal delivery over a 10‐year period (n = 86 242, 2009–2018) at the Rotunda Hospital were reviewed. The overall incidence of OASIS was compared with incidence rates stratified by parity and type of vaginal birth.ResultsThe 10‐year vaginal delivery rate was 69% (n = 59 187) where 24 580 women (42%) were primiparous and 34 607 women (58%) were multiparous. SVD rate was 74% and OVD rate was 26%. The overall incidence of OASIS was 2.9%. The incidence of OASIS in OVD was 5.5% and the incidence in SVD was 2%. Of 498 multipara who sustained OASIS, 366 (73%) had an SVD without episiotomy compared with 14 (3%) who had an episiotomy. There was a significant reduction of OASIS over the 10‐year period in primipara who had an OVD but no reduction in the other groups.ConclusionThe primiparous OVD group had a significant reduction of OASIS. Continued education around perineal protection and episiotomy at SVD could positively impact further reduction in OASIS, particularly in the SVD groups.
Exploration of novel syringic esters as antifungal agent against phytopathogenic fungi of maize: Structure‐activity studies
Authors: Sahni Tanvi , Sharma Sunita , Verma Diksha , Kaur Harleen , Kumar Sachin 
Published: May 2023

AbstractThe production of maize is limited by major diseases such as foliar blights, stalk rot, maydis leaf blight; banded leaf and sheath blight and many more. Synthesis of ecologically sustainable and naturally derived products can help us counter these diseases. Hence, Syringaldehyde (a natural occurring isolate) should explore as a viable option as green agrochemical. We performed a structure‐activity study to optimize syringaldehyde and its physicochemical properties. A series of novel syringaldehyde esters was synthesized and investigated focusing on esters’ nature of lipophillicity, and membrane affinity. Tri‐chloro acetylated ester of syringaldehyde was emerged as broad‐spectrum fungicide.
Is it time to rethink disability assessment in low back pain? Reliability, internal consistency, and construct validity of the Brazilian WHODAS 2.0 for chronic low back pain
Authors: Silva Tuyra Francisca Castro e , Medeiros Paula Maciel de Sousa Silva , Leite Camila Ferreira , Castro Shamyr Sulyvan , Nunes Ana Carla Lima , Jesus‐Moraleida Fabianna Resende 
Published: May 2023

AbstractBackground and PurposeThe World Health Disability Assessment Schedule 2.0 (WHODAS 2.0) was developed to assess health and disability based on the biopsychosocial model. The WHODAS 2.0 has not been validated for Brazilians with chronic non‐specific low back pain (LBP). We aimed to evaluate the reliability, internal consistency, and construct validity of the Brazilian version of the WHODAS 2.0 in patients with chronic LBP.MethodsMethodological study. The Brazilian version of the WHODAS 2.0 was applied to 100 volunteers with chronic nonspecific LBP. Test‐retest reliability, internal consistency, and construct validity were assessed using the Spearman correlation test, Cronbach's alpha (α) coefficient, and Spearman's correlation test between WHODAS 2.0, the Oswestry Disability Index (ODI), Roland‐Morris Disability Questionnaire (RMDQ), and Fear Avoidance Beliefs Questionnaire (FABQ), respectively.ResultsWHODAS 2.0 showed satisfactory test‐retest reliability with a moderate correlation for total WHODAS 2.0 (r = 0.75, p < 0.05). Internal consistency was adequate for all domains and total score (α = 0.82–0.96). Regarding construct validity, WHODAS 2.0, ODI (r = 0.70, p < 0.05), and WHODAS 2.0 and RMDQ (r = 0.71, p < 0.05) had significant correlations. Total WHODAS 2.0 and FABQ‐Phys subscale scores correlated moderately (r = 0.66, p < 0.05).DiscussionThe Brazilian WHODAS 2.0 was proved to be a valid and reliable tool for patients with chronic LBP. The item referring to sexual intercourse had 27% and 30% of the missing values during the test and retest stage, respectively and had a high percentage of missing data for work‐related questions (41% missing data) in the life activities domain; therefore, the data must be interpreted with caution.Implications for Physiotherapy PracticeWHODAS 2.0 can be used as a disability assessment strategy from a biopsychosocial perspective in this population.