bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improving university students’ mental health literacy using experiential learning opportunities
Authors: Reis Arianne , Nguyen Vivien , Saheb Rowena , Rutherford Erin , Sperandei Sandro 
Published: January 2023

Objectives: University students represent a vulnerable population to mental health and wellbeing issues. However, young people are likely to delay or fail to engage in help-seeking behaviours. Embedding mental health learning opportunities in curriculum design may improve the mental health and wellbeing of students, but there are challenges to embedding this material in non-health disciplines where students’ intrinsic interests may not align with mental health–themed coursework. To explore this challenge, the present study involved embedding mental health literacy learning into an Event Management course through an experiential learning opportunity. Design: A quasi-experimental design involving university students divided into intervention groups ( n = 40) and control groups ( n = 83). Setting: Students in the intervention groups managed events across campuses of a major Australian university in support of a University Mental Health and Wellbeing Day. Students in the control groups managed non-mental health events. Method: Pre- and post-event surveys compared students’ perceptions of experiential learning, of the effectiveness of student-led events in promoting mental health literacy and help-seeking behaviours in themselves and peers, and of embedding mental health learning into an experiential learning framework. Results: Results suggest that experiential learning opportunities that contain mental health literacy content in addition to course content can be valuable without interruption to core learning aims. Conclusion: This study is one of the first to evaluate the impact of innovative curriculum designs that embed mental health literacy in non-health disciplines, highlighting the opportunities for creative approaches to improving mental health education in universities.
“I Don’t Feel at Home in This World” Sexual and Gender Minority Emerging Adults’ Self-Perceived Links Between Their Suicidal Thoughts and Sexual Orientation or Gender Identity
Authors: van Bergen Diana D. , Dumon Eva , Parra Luis A. , Motmans Joz , Biedermann Lesley C. , Gilissen Renske , Portzky Gwendolyn 
Published: January 2023

Objectives To examine whether sexual and gender minority (SGM) emerging adults perceived their SGM status was linked to suicidal ideation, and to explore if their responses fell within tenets of the minority stress framework. Method Open text (survey) responses of Dutch and Flemish SGM emerging adults ( n  =  187) were thematically analysed using the constant comparative comparison method for qualitative analysis. Results We identified 8 themes in our qualitative analysis. Two themes fell within the scope of the minority stress framework that has received little attention: (1) concerns about relationships and family planning and (2) feeling different (internal stressor). Two additional themes emerged largely beyond the scope of existing minority stress framework studies on suicidality: (3) SGM-related questioning; (4) negativity in LGBT communities. Four established minority stress framework themes emerged: (5) gender identity stress; (6) victimization; (7) coming-out stress; (8) psychological difficulties linked to SGM status. Conclusion Suicide prevention needs to focus on supporting SGM emerging adults who worry about feeling “different”, or who have concerns over their romantic and family life, on reducing gender minority stress, as well as on caring for those who are victimized due to their sexual or gender identity.
Newcomer Women's Experiences with Perinatal Care During the Three-Month Health Insurance Waiting Period in Ontario, Canada
Authors: Pimienta Jessica , Guruge Sepali , St-Amant Oona , Catallo Cristina , Hart Corinne 
Published: January 2023

Background The three-month health insurance waiting period in Ontario reinforces health inequities for newcomer women and their babies. Little is known about the systemic factors that shape newcomer women's experiences during the OHIP waiting period. Purpose To examine the factors that shaped newcomer women's experiences with perinatal care during the three-month health insurance waiting period in Ontario, Canada. Methods This qualitative study was informed by an intersectional framework, and guided by a critical ethnographic method. Individual interviews were conducted with four newcomer women and three perinatal healthcare professionals. Participant observations at recruitment and interview sites were integral to the study design. Results The key systemic factors that shaped newcomer women's experiences with perinatal care included social identity, migration, and the healthcare system. Social identities related to gender, race, and socio-economic status intersected to form a social location, which converged with newcomer women's experiences of social isolation and exclusion. These experiences, in turn, intersected with Ontario's problematic perinatal health services. Together, these factors form systems of oppression for newcomer women in the perinatal period. Conclusions Given the health inequities that can result from these systems of oppression, it is important to adopt an upstream approach that is informed by the Human Rights Code of Ontario to improve accessibility to and the experiences of perinatal care for newcomer women.
Safety of tacrolimus use during pregnancy and related pregnancy outcomes in patients with systemic lupus erythematosus: A retrospective single-center analysis in Japan
Authors: Kitada Ayako , Nakai Takehiro , Fukui Sho , Rokutanda Ryo , Okada Masato , Kusaoi Makio , Yamaji Ken , Tamura Naoto 
Published: January 2023

Objective Tacrolimus is one of the drugs that can be used in pregnancies complicated with systemic lupus erythematosus (SLE), but there are still few reports on its pregnancy outcomes. Although tacrolimus has been reported to cause adverse events, such as increased blood pressure, abnormal glucose metabolism, and susceptibility to infection, there have been no studies on the impact of tacrolimus in SLE pregnancies at these points. We performed a retrospective observational study of pregnancies complicated by SLE at St Luke’s International Hospital in Tokyo from April 2003 to August 2021. Methods Basic clinical information on SLE, pregnancy outcomes, disease activity before and after pregnancy, laboratory results, blood pressure, blood glucose levels, treatment regimens, and presence of infection was extracted from electronic medical records. We defined overall adverse pregnancy outcomes (APOs) as follows: (1) fetal death after 10 gestational weeks, (2) preterm delivery, (3) delivery due to hypertensive disorders of pregnancy, preeclampsia, or placental insufficiency, or (4) the diagnosis of small for gestational age infants. We also examined whether there was a statistical difference in APO incidence between patients treated with and without tacrolimus. Results Pregnancy outcomes were obtained for 48 patients with a total of 60 pregnancies complicated by SLE. In 20 (33.3%) of these pregnancies, the patients took tacrolimus, and 28 (46.7%) of the pregnancies had APOs. APO incidence did not statistically differ between the tacrolimus and non-tacrolimus groups in the multivariate analysis ( p = 1.00, adjusted OR 1, 95% CI: 0.23–4.39). Multiple regression analyses indicated that tacrolimus use did not significantly affect systolic blood pressure in the third trimester (B = −2.23, p = .74) or blood glucose levels in the first trimester (B = 10.2, p = .056). Incidence of infections did not significantly differ between patients treated with and without tacrolimus in the univariate analysis (10.8% vs. 21.1%, p = .42). Conclusion Tacrolimus did not significantly affect pregnancy outcomes, blood pressure, or glucose levels. Further research is required to confirm its effects in a larger population.
Correlation of Screen Time With Eating Behavior Among School-Going Children Aged 8 to 10 Years in East Delhi, India
Authors: Semar Riya , Bakshi Neha 
Published: January 2023

Background and aim: Excessive screen time (ST) negatively impacts physical activity and eating behavior among children <5 years. There is a dearth of data on older Indian children; hence, the present study aimed to assess the effect of ST on eating behavior among older children. Methods: The present cross-sectional study purposively recruited 100 school-going children. E-questionnaire was prepared to gather information regarding the demographic profile and self-reported weight and height. For the assessment of ST, the SCREENS questionnaire was used. Eating behavior was assessed using the Children Eating Behavior Questionnaire, and for physical activity, the PAQ-C was used. The nutrition status of children was assessed using body mass index (BMI) for age cut-offs. Results: The results revealed that 52% of the children were using screens for > 4 hours per day excluding school-related activities and online classes. ST of children was directly proportional to the parent’s ST ( P < .05). There was a negative correlation between ST and the physical activity of children ( P < .01). A positive correlation was observed between ST and emotional overeating, desire to drink, slow eating, satiety responsiveness, food fussiness, and emotional undereating ( P < .01). BMI was positively associated with ST and negatively associated with physical activity, though the results were not significant. Satiety responsiveness (a food-avoiding subscale) was negatively associated with BMI ( P < .05). Conclusion: The present study concludes that excessive ST among 8 to 10 years old school-going children has been associated with physical inactivity and poor eating behavior which could lead to an increased risk of being overweight and obese.
Philtral Height Discrepancy in Patients with Complete and Incomplete Cleft Lips + /-Palate – Results from a Single Nation Consecutive Cohort
Authors: Rivers CM , Drake D , Devlin MF , Russell CJH 
Published: January 2023

Introduction The aim of unilateral cleft lip repair is to restore form and function, including symmetrisation of cleft and non-cleft philtral height. Expectation of best outcome is achieved in situations with minimal asymmetry and is assumed occurs most often in incomplete cleft lip only patients. We sought to investigate philtral height discrepancy (PHD) in children with unilateral cleft lip + /-palate from a single nation cohort. Methods Review of prospectively collected PHD measurements taken at time of surgery for all children undergoing unilateral cleft lip repair in Scotland born Jan 2017—December 2020. Data was collected using Microsoft Excel and analysed using embedded statistical software. Results 102 consecutive patients with unilateral lip involvement were identified from the national database. 94 had prospectively documented PHD (92.2%). The majority of patients had an isolated cleft lip (51.1%). Incomplete clefts presented more frequently (52.1%) than complete clefts (47.9%). Mean PHD for the whole cohort was 3.91mm (standard deviation 1.01mm, range 1–6mm). The difference in mean PHD (in-complete versus complete) was 1.1mm (3.4 vs. 4.5, p < 0.001). For lip only versus lip and palate the difference in mean PHD was 1.0mm (3.4 vs. 4.4, p < 0.001). Conclusions This single country consecutive cohort review of PHD in children undergoing unilateral cleft lip repair statistically supports the anecdote that patients with an incomplete cleft lip and isolated cleft lip have lesser asymmetry at presentation. This study presents a consecutive cohort with a greater range of PHD than has previously been reported in the literature.
Design and experiment of a large-scale space micro-vibration simulator
Authors: Zhu He , He Shuai , Shen Junli , Xia Mingyi , Qin Chao , Wang Xiaoming , Sun Xiangyang , Xu Zhenbang 
Published: January 2023

To solve the problems of difficult vibration sources simulation in the ground test of the on-orbit optical load, a multi-dimensional micro-vibration simulator based on the improved Gough–Stewart platform was designed, which can effectively reproduce the characteristics of wide frequency distribution and small vibration magnitude of space micro-vibration. The analytical formula was derived by using the virtual frequent principle and the Newton–Euler equation for the natural frequency of the system, and the simulator’s configuration was optimized. The structure of legs was designed and optimized according to the optimal configuration parameters. Finally, the micro-vibration simulator was tested, and the test results showed that the output bandwidth of the simulator was 5–300 Hz and the maximum magnitude error was 8%, thus demonstrating the multi-dimensional micro-vibration simulation platform has the characteristics of large frequent bandwidth, high load carrying capacity, and small vibration magnitude.
Scale and spread of innovation in health and social care: Insights from the evaluation of the New Care Model/Vanguard programme in England
Authors: MacInnes Julie , Billings Jenny , Coleman Anna , Mikelyte Rasa , Croke Sarah , Allen Pauline , Checkland Kath 
Published: January 2023

Objective Little is known about how to achieve scale and spread beyond the early local adoption of an innovative health care programme. We use the New Care Model – or ‘Vanguard’ – programme in the English National Health Service to illuminate the process, assessing why only one of five Vanguard programmes was successfully scaled up. Methods We interviewed a wide range of stakeholders involved in the Vanguard programme, including programme leads, provider organisations, and policymakers. We also consulted relevant documentation. Results A lack of direction near the end of the Vanguard programme, a lack of ongoing resources, and limited success in providing real-time monitoring and evaluation may all have contributed to the failure to scale and spread most of the Vanguard models. Conclusions This programme is an example of the ‘scale and spread paradox’, in which localism was a key factor influencing the successful implementation of the Vanguards but ultimately limited their scale and spread.
Disaster Diaries: Qualitative Research at a Distance
Authors: Mueller Grace , Barford Anna , Osborne Helen , Pradhan Kaajal , Proefke Rachel , Shrestha Soniya , Pratiwi Andi M. 
Published: January 2023

The common-place quantification of humanitarian disasters enables rapid and informed crisis responses. In disaster settings, understanding feelings and perceptions regarding individuals’ experiences, livelihood disruptions and coping mechanisms can also be valuable for extending and deepening quantitative insight. This paper explores the potential for diary methods to capture extensive, nuanced data from marginalised groups during a disaster, by drawing upon a study with 100 young diarists (aged 15–29) who produced 1418 diary entries over 4 months. In particular, we share how diary-methods can be designed inclusively, through addressing themes of equitable research partnerships, supporting more vulnerable participants, ensuring data quality, data management, participatory analysis, and budgeting for collaborative research.
A noval prognostic signature of the N7-methylguanosine (m7G)-related miRNA in lung adenocarcinoma
Authors: Duan Han-ping , Yan Jian-hui , Nie Lin , Wang Ye , Xie Hui 
Published: January 2023

Abstract
Background
Lung adenocarcinoma (LUAD) is characterized by high morbidity and mortality rates and poor prognosis. N7-methylguanosine play an increasingly vital role in lung adenocarcinoma. However, the prognostic value of N7-methylguanosine related-miRNAs in lung adenocarcinoma remains unclear.

Methods
In the study, the mRNA and miRNA expression profiles and corresponding clinical informations were downloaded from the public database. The prognostic signature was built using least absolute shrinkage and selection operator Cox analysis. The Kaplan–Meier method was used to compare survival outcomes between the high- and low-risk groups. Signatures for the development of lung adenocarcinoma were tested using univariate and multivariate Cox regression models. Single-sample gene set enrichment analysis was used to determine the immune cell infiltration score. First, we predicted METTL1 and WDR4 chemosensitivities based on a public pharmacogenomics database. The area under the receiver operating characteristic curve showed that the performance of signature in 1-,3-, and 5-year survival predictions were 0.68, 0.65, and 0.683, respectively.

Results
We established a novel prognostic signature consisting of 9 N7-Methylguanosine related miRNAs using least absolute shrinkage and selection operator Cox analysis. Patients in the high-risk group had shorter survival times than those in the low-risk group did. The calibration curves at 1, 3, and 5-year also illustrate the high predictive power of the structure. Signature was corrected using the Toumor stage. The expression levels of METTL1 and WDR4 significantly correlated with the sensitivity of cancer cells to antitumor drugs.

Conclusions
A novel signature constructed using 9 N7-methylguanosine related-miRNAs can be used for prognostic prediction.
Correlation between surgical segment mobility and paravertebral muscle fatty infiltration of upper adjacent segment in single-segment LDD patients: retrospective study at a minimum 2 years’ follow-up
Authors: Guan Jianbin , Zhao Dingyan , Liu Tao , Yu Xing , Feng Ningning , Jiang Guozheng , Li Wenhao , Yang Kaitan , Zhao He , Yang Yongdong 
Published: January 2023

Abstract
Objective
The purpose of this study was to investigate the relationship between surgical segment mobility and fatty infiltration of the adjacent segment paravertebral muscles in patients with single-segment lumbar degenerative disease (LDD) who underwent decompression with fusion or dynamic stabilization.

Methods
Retrospective analysis of patients who underwent lumbar decompression combined with titanium rod fixation intertransverse fusion (PITF group), Isobar TTL dynamic stabilization (TTL group) or Isobar EVO dynamic stabilization (EVO group) for single-segment lumbar degenerative disease, from March 2012 to July 2018. The preoperative and final follow-up clinical indexes C-LDSI and the measured imaging indexes (range of motion of the surgical segment and the upper adjacent segment, and Goutallier grade of the upper adjacent segment) were counted, and the differences between the preoperative and final follow-up indexes were compared.

Results
According to the inclusion and exclusion criteria, 68 patients were included in this study, 21 in the PITF group, 24 in the TTL group, and 23 in the EVO group. At the final follow-up, the C-LSDI score had significantly higher in the PITF group than the TTL and EVO groups, and the C-LSDI score was a very strongly negatively correlated with ROM of surgical segment (r=-0.7968, p < 0.001). There was a strong negative correlation between surgical segment and upper adjacent segment mobility (r = -0.6959, p < 0.001). And there was a very strong negative correlation between ROM of surgical segment and upper adjacent segment paravertebral muscle Goutallier classification (r = -0.8092, p < 0.001), whereas the ROM of the upper adjacent segment was strong positive correlated with the Goutallier classification (r = 0.6703, P < 0.001).

Conclusion
Compared with decompression combined with rigid fusion, decompression combined with dynamic fixation for single-segment lumbar degenerative disease can significantly reduce postoperative low back stiffness. And a certain range of increased mobility of the dynamic stabilization device can effectively reduce the compensatory mobility of the upper adjacent segment and slow down the fatty infiltration of the paravertebral muscle in the adjacent segment.
A novel 1.38-kb deletion combined with a single nucleotide variant in KIAA0586 as a cause of Joubert syndrome
Authors: Shen Yue , Lu Chao , Cheng Tingting , Cao Zongfu , Chen Cuixia , Ma Xu , Gao Huafang , Luo Minna 
Published: January 2023

Abstract
Background
KIAA0586, also known as Talpid3, plays critical roles in primary cilia formation and hedgehog signaling in humans. Variants in KIAA0586 could cause some different ciliopathies, including Joubert syndrome (JBTS), which is a clinically and genetically heterogeneous group of autosomal recessive neurological disorders.

Methods and Results
A 9-month-old girl was diagnosed as JBTS by the “molar tooth sign” of the mid-brain and global developmental delay. By whole-exome sequencing, we identified a single nucleotide variant c.3303G > A and a 1.38-kb deletion in KIAA0586 in the proband. These two variants of KIAA0586 were consistent with the mode of autosomal recessive inheritance in the family, which was verified using Sanger sequencing.

Conclusions
This finding of a compound heterozygote with a 1.38-kb deletion and c.3303G > A gave a precise genetic diagnosis for the patient, and the novel 1.38-kb deletion also expanded the pathogenic variation spectrum of JBTS caused by KIAA0586.
Universal health coverage in Pakistan: is the health system geared up to take on the challenge?
Authors: Shaikh Babar Tasneem , Ali Nabeela 
Published: January 2023

Abstract
Background
There is a strong and wide consensus that Pakistan must pursue universal health coverage (UHC) attainment as the driving force for achieving sustainable development goals by 2030. Nevertheless, several institutional and socioeconomic challenges may hinder the progress toward UHC.

Main body
It is important that the health system of Pakistan must be transformed to strengthen all three dimensions of UHC i.e. maximizing the population covered, increasing the range of services offered, and reducing the cost-sharing. To make UHC dream a reality in Pakistan, there are some pre-requisites to meet upfront: a) budgetary allocation for health as percentage of GDP must be increased; b) health system’s readiness especially in the public sector ought to improve in terms of human resource and availability of essential services; c) safety nets for health must continue regardless of the change in the political regimes; d) decrease the reliance on donors’ funding; and e) accountability to be ensured across the board for service providers, managers, administrators and policymakers in the health system.

Conclusion
COVID-19 pandemic has revealed some major gaps in the health system’s capacity to deliver equitable healthcare, which is a cornerstone to achieving the UHC agenda. The priority-setting process will need to be aligned with the SDGs to ensure that the agenda for action towards 2030 is comprehensively addressed and successfully accomplished preferably before, but hopefully not beyond the targeted dates.