bluuebunny/crossref_metadata_2025_split huggingface dataset:
Therapeutic Efficacy of Malachite Green-Based Photodynamic Therapy in Acute Myeloid Leukemia
Authors: ÖZLEM ÇALIŞKAN Serçin , DURAN Ömer Furkan , ASLAN Cem , ÖZEN Hüsne , ÇALIŞKAN Metin , ILIKÇI SAĞKAN Rahşan 
Published: March 2023

Aim: Acute myeloid leukemia (AML) is a disease characterized by relapse and treatment resistance in most patients. Therefore, there is a need for targeted therapies in AML. Photodynamic therapy (PDT) is a promising alternative for the treatment of malignant tumors. Also, PDT has the potential to be used individually or complementally in the treatment of leukemia. In this study, it was aimed to investigate possible the effect of malachite green (MG)-based PDT on acute myeloid leukemia cells.
Materials and Methods: Cells were incubated with 0.19, 0.39, 0.78,1.56, 3.125, and 6.25 µM MG for one hour and irradiated with 46.4 J/cm2 of light. The trypan blue test was used to assess the viability of cells, and the change in mitochondrial activity was determined by MTT. Morphological features were determined by Giemsa staining and scanning electron microscopy. Cell cycle and Annexin V/PI assays (measuring fluorescence emitted by staining reagents) were measured by flow cytometry.
Results: With the combination of MG and light, HL60 cell viability was found to be significantly reduced compared to the control group. Giemsa staining and SEM results showed that 3.125 μM MG-based PDT induced various morphological changes in cells typical for apoptosis. Late apoptosis was observed in cells treated with 3.125 μM MG combined PDT according to Annexin/PI staining, further showing that it caused an arrest in the subG1 phase of the cell cycle.
Conclusion: MG-based PDT has the potential to inactivate HL60 cells. Thus, MG-based PDT may ensure a promising approach for treating acute myeloid leukemia cells.
Investigation of the Effect of Initial Cardiac Rhythm on Survival in Patients Admitted with Cardiopulmonary Arrest to the Emergency Department
Authors: ŞAHİN Taner , NALBANT Ahmet Furkan 
Published: March 2023

Objective: Cardiopulmonary arrest is the condition of insufficient oxygen delivery to tissues as a result of sudden cessation of circulatory and respiratory functions. This study aimed to investigate the causes of arrest in patients admitted with cardiopulmonary arrest and the effect of initial cardiac rhythm on patient survival.
Material and Methods: Out of 1126 patients who had an in-hospital and out-of-hospital cardiac arrest and were admitted to our emergency department, 1009 patients were included in this retrospective study following the exclusion criteria. In addition to the demographic characteristics of patients, their initial rhythms and mortality states were assessed.
Results: There was a significant relationship between patients’ clinical outcomes and initial cardiac rhythms (p
AS REFLEXÕES POSSÍVEIS ENTRE A PEDAGOGIA SOCIAL E AS PRÁTICAS EDUCATIVAS NÃO ESCOLARES NAS ATIVIDADES COTIDIANAS DA EDUCAÇÃO INFANTIL
Authors: Vianna Ferreira Arthur 
Published: March 2023

O presente artigo, de fundamentação teórica sobre Pedagogia Social, tem como objetivo refletir sobre as possíveis contribuições do campo do saber da Pedagogia Social para as práticas educativas não escolares na educação infantil. As contribuições desse artigo surgem de pesquisas, sistemáticas e contínuas, sobre as práticas educativas não escolares realizadas pelo Grupo de Estudos, Pesquisas e Extensão Fora da Sala de Aula, da Faculdade de Formação de Professores da Universidade do Estado do Rio de Janeiro (FFP/UERJ) desde 2016. Assim, esse texto buscar definir o campo do saber da Pedagogia Social com seus principais temas de reflexão e logo depois, se trará pontos que se apresentam relevantes para a organização dos processos de ensino-aprendizagem na educação infantil e que pode ser espaço de possível espaço de atuação da Pedagogia Social. Dessa forma, infere-se que o campo do saber específico da Pedagogia Social tem um potencial na formação docente para as práticas não escolares desenvolvidas dentro da educação infantil transformando-se, assim, em um elemento importante a ser levado em consideração na formação docente inicial – e continuada – para o trabalho com/na primeira infância. Assim como, nas relações socioeducativas que buscam o desenvolvimento humano, cognitivo e afetivo dessa modalidade de ensino na educação brasileira.
Democracia Participativa bajo la Constitución Política de 1991
Authors: Álvarez Mora Jesús Hernando 
Published: March 2023

El artículo tiene como objetivo, desde el punto de vista analítico, abordar el estudio de la democracia participativa en Colombia a partir de la Constitución Política de 1991, con el propósito de auscultar su eficacia, no solamente formal sino material. Sobre la democracia, como forma de gobierno, se hace una aproximación conceptual, teórica e histórica, tanto a nivel general como nacional, con el fin de proporcionar mayores insumos en la comprensión de la evolución de la democracia participativa y su actual regulación constitucional, legal y jurisprudencial. Finalmente, se aborda, de manera breve, el estudio de los principales mecanismos de participación ciudadana de naturaleza política que introdujo el constituyente de 1991.
Гуманитарное образование – ресурс развития человеческого капитала в условиях цифровой трансформации
Authors: АЛИЕВА Б.Ш. , РАБАДАНОВ М.Х. 
Published: March 2023

Раскрывается сущность гуманитарного образования как ресурса развития человеческого капитала в условиях цифровой трансформации. Отмечается, что его реализация требует обновления системы образования. Выделяются для профессионального обсуждения острейшие проблемы высшего образования. Определяется роль гуманитарного знания, нацеленного на решение комплекса проблем, относящихся к духовной культуре личности. Гуманитарное образование рассматривается как одни из наиболее значимых факторов, способствующих развитию у обучающихся способностей мыслить, чувствовать, действовать.
The essence of humanitarian education as a resource for the development of human capital in the context of digital transformation is revealed. It is noted that its implementation requires updating the education system. The most acute problems of higher education are singled out for professional discussion. The role of humanitarian knowledge, aimed at solving a complex of problems related to the spiritual culture of the individual, is determined. Humanities education is considered as one of the most signifi cant factors contributing to the development of students’ abilities to think, feel, and act.
Об изменении нормативно-правого обеспечения подготовки аспирантов
Authors: Сливин Т.С. , Воронов В.Н. 
Published: March 2023

Рассматриваются некоторые изменения в организации и содержании подготовки аспирантов. Проведен анализ отечественного законодательства в соответствующей области. Выделены и проанализированы наиболее острые проблемы в сфере подготовки аспирантов. Предложены варианты решения обозначенных проблем.
Some changes in the organization and content of postgraduate training are considered. The analysis of domestic legislation in the relevant area was carried out. The most acute problems in the fi eld of postgraduate training are identifi ed and analyzed. Options for solving the identifi ed problems are proposed.
Экологическое образование студентов как неотъемлемая составляющая подготовки специалистов в техническом вузе
Authors: Мухаметшина Р.М. 
Published: March 2023

Обоснована актуальность формирования экологической компетентности как обязательного условия эффективности профессиональной деятельности специалиста. Показано, что формирование у будущего специалиста экологически грамотного отношения к решению профессиональных задач выступает необходимым условием преодоления негативных последствий антропогенного влияния на окружающую среду. Определены пути реализации экологического подхода, способствующие повышению эффективности процесса формирования экологической компетентности при изучении химии окружающей среды в техническом вузе.
The relevance of the formation of environmental competence as a prerequisite for the eff ectiveness of the professional activity of a specialist is substantiated. It is shown that the formation of an environmentally competent attitude towards solving professional problems in a future specialist is a necessary condition for overcoming the negative consequences of anthropogenic impact on the environment. The ways of implementing the ecological approach are determined, which contribute to the increase in the effi ciency of the process of formation of ecological competence in the study of environmental chemistry in a technical university.
Образовательные треки как новый инструмент в проектировании системы обучения персонала
Authors: Фивейский В.Ю. 
Published: March 2023

Приведен опыт Университета Правительства Москвы по созданию новых обучающих форматов – образовательных треков для развития сотрудников органов исполнительной власти и подведомственных им организаций Правительства Москвы. Обосновано, что применение образовательных треков позволяет связать результаты оценки компетенций сотрудника с его дальнейшим обучением, помочь ему вместе с руководителем выстроить свою образовательную траекторию. Рассмотрены персональные образовательные треки развития, востребованные сотрудниками органов власти и организаций города Москвы. Представлены подходы к разработке командных треков развития, примеры разработанных Университетом Правительства Москвы командных программ. Показаны основные этапы оценки эффективности персонального и командного обучения. Сделан вывод о том, что образовательные треки мотивируют сотрудника и команду к самообучению, дают возможность самостоятельно планировать время на развитие и создают продуктивную среду для построения обучающейся организации.
The experience of the Moscow Government University in creating new training formats – educational tracks for the development of employees of executive authorities and subordinate organizations of the Moscow Government is given. It is substantiated that the use of educational tracks makes it possible to link the results of an employee’s competency assessment with his further training, to help him build his educational trajectory together with his manager. The personal educational tracks of development, demanded by employees of authorities and organizations of the city of Moscow, are considered. Approaches to the development of team development tracks, examples of team programs developed by the University of the Government of Moscow are presented. The main stages of evaluating the eff ectiveness of personal and team training are shown. It is concluded that educational tracks motivate the employee and the team to self-learning, provide an opportunity to independently plan time for development and create a productive environment for building a learning organization.
Проект «Московское долголетие» как фактор развития социальной активности граждан старшего поколения
Authors: Гордин А.В. 
Published: March 2023

Рассматриваются социально-психолого-педагогические аспекты проблемы социальной активности граждан старшего поколения, условия, способствующие ее развитию. Представлен опыт реализации проекта «Московское долголетие», направленного на решение данной проблемы. Обоснована необходимость дальнейшего совершенствования проекта и постоянного пополнения знаний по психологии, разработке и внедрению новых технологий работы со страшим поколением у реализующих его специалистов. Ключевые слова: пожилой человек, социальная активность, проект «Московское долголетие», психология личности, самореализация, социальная работа.
The social-psychological-pedagogical aspects of the problem of social activity of citizens of the older generation, the conditions conducive to its development are considered. The experience of implementing the project “Moscow longevity” aimed at solving this problem is presented. The necessity of further improvement of the project and constant replenishment of knowledge in psychology, development and implementation of new technologies for working with the older generation among the specialists implementing it is substantiated.
Correlation Between Platelets Count, Platelet Index and D-Dimer in Covid-19 Patients
Authors: Tolla Nelly , Rachmawaty Rachmawaty , Anggeraini Andi Salsa , R Darmmawaty , Nur Faidah 
Published: March 2023

Hypercoagulation in the alveoli of the lungs is one of the causes of death in SARS-CoV2 virus infection. Hypercoagulation is defined by an elevation in D-Dimer, which typically rises on the fifth day of therapy. This parameter is not available in all hospitals and is still relatively expensive in preventing premature death. Platelets count and indices are suggested to describe the thromboinflammatory condition in COVID-19 patients. This research is an observational analytic study with a cross-sectional study design in 59 COVID-19 patients treated at Hassanuddin University Hospital. The patients who are declared COVID-19 based on the results of radiological examinations and PCR swabs underwent routine blood tests and D-Dimer before undergoing therapy. Data were analyzed using the Spearmen test in SPSS version 26 to reveal the correlation between platelet count, platelet indices, and D Dimer in COVID-19 patients with severe and non-severe conditions. Platelet count, platelet indices, especially MPV, and D-Dimer values were found to correlate in both groups COVID-19 using the Spearman rho correlation test (p 0.000) with strengths correlation between -44.6 and 60.5. There was a significant association between platelet count and MPV value with D-Dimer in COVID-19 patients.
Determining a Flow Zone Indicator in Conventional and Unconventional Reservoirs Using Resistivity Logs
Authors: González José Wilfredo , Linares Alejandro Jose , Rodriguez Diego Armando , Chacon Alexander Castro , Vasquez Jose 
Published: March 2023

AbstractThe Flow Zone Indicator (FZI) depends on permeability and porosity. The permeability of a reservoir is one of the most difficult properties to determine, since the models to calculate permeability use input from several logs (gamma ray, density-neutron, sonic, etc.). Permeability modeling is done using complex methodologies such as: matching learning, fuzzy logic, cluster, multiple linear regression, etc., and at the end, permeability models end up being unique for each reservoir. The objective of this work is to determine a flow zone indicator (FZI) from the deep (Rt) and shallow resistivity (Rs) logs in conventional and unconventional reservoirs.Basically, the methodology consisted of studying the phenomenon of the invasion of mud filtration during the drilling of the wells, and the behavior of resistivity logs. Invasion affects some properties of porous and permeable formations in the vicinity of a well. In general, the invasion is small in very porous and permeable reservoirs, the opposite is in poorly permeable reservoirs, tight, vuggy carbonates or fractured formations. Based on the above, a mathematical model was proposed to determine the FZI, as a logarithmic function which is applicable in both water and oil-based muds. If the resistivities are equal, then there is no mud filtration invasion, and the permeability is zero. If the difference in resistivity is different from zero, there is invasion of the sludge filtrate and therefore the permeability is greater than zero, indicating flow zones in the reservoir. There are other borehole, formation and tool conditions that may generate difference between RT and RS which are not related to invasion. These will be explained briefly below.The FZI model identified the flow zones in the reservoir. FZI from core and Nuclear Magnetic Resonance (NMRI) log data correlated with the FZI calculated with the model. The mobility data of formation testers agreed with the calculated FZI. Also, spectral noise and PLT logs inflow zones showed excellent correlation with the FZI.This methodology can be applied in any type of reservoir. In exploration wells the methodology allows to define and propose the best zones to set the formation testers, thus optimizing operational time. Before performing a petrophysical assessment, FZI results can identify prospective zones of the reservoir based on rock quality. Also, the production and injection behavior of the wells can be monitored with the obtained results. And finally, the FZI as an independent variable decreases the uncertainty of a permeability model, because the FZI is intimately related to the texture of the rock and the facies. The simplest expression of this is the resistivity variation with changes of porosity. Therefore, if porosity is related to facies, so is the formation factor (F), and then the resistivity log becomes an excellent facies discriminator.
A new preoperative ultrasound evaluation for optimal capacity management of emergency surgery patients: a randomized controlled clinical study
Authors: Lin Miao , Gao Wenli , Liu Yingying , Ke Shengpei , Tian Ya , Song Yifeng , Chen Miaoxia , Li Chao , Lei Pengfei , Wang Hao , Liu Yanyan , Dai Zhongliang 
Published: March 2023

Abstract
Background: Patients undergoing emergency surgery often experience fluid depletion. Therefore, it is critical to use an efficient emergency preoperative blood volume assessment method. Based on current ultrasound assessment, a new method for ultrasound diagnosis and treatment, called Dai's preoperative ultrasound assessment (DPUA), has been developed. Three cardiovascular ultrasound views of DPUA include apical four-chamber, parasternal long-axis, and subxiphoid inferior vena cava views. Data of cardiovascular ultrasound slices correspond to volume conversion and fluid rehydration protocol ultrasound integration algorithm, which can be used to guide volume management in emergency surgery patients.
Methods: This trial was a single-center randomized controlled study whose subjects were 60 patients undergoing emergency general anesthesia with no one dropped out. They were divided into experience group and ultrasound group. In experience group, patient volume status was assessed through blood pressure, heart rate, and fluid supplementation for patients based on the personal experience of anesthesiologists. In ultrasound group, the anesthesiologist chose different rehydration solutions through DPUA.
Results: The main outcome indicator of this study was the stability of the circulatory blood pressure, which was mainly reflected in the comparison of the average arterial pressure at different times. The difference in the mean arterial pressure at the beginning of surgery was statistically significant (P=0.003**), and blood pressure fluctuation in ultrasound group was smaller than that in experience group, indicating that DPUA maintained better stability of the volume at the beginning of the operation. The experience group used more crystalloids within 30 min of choosing the fluid replacement regimen, and the ultrasound group used more colloids (P=0.036*).
Conclusions: Preoperative ultrasound assessment of the DPUA could effectively and accurately assess the patient's cardiac function and volume status, as well as better guide perioperative fluid management.
Trial registration: Registration number: ClinicalTrials.gov ID NCT04111783. First registered on 01/10/2019, https://clinicaltrials.gov/.
Spectrum Sensing based on Similar Median Value
Authors: Bai Xiaojuan , Li Xingxing , Xu Jing 
Published: March 2023

Abstract
Spectrum sensing based on the covariance matrix algorithm does not need the prior information of the authorized user and is easy to implement. However, at low SNR, the difference between the covariance matrix elements becomes smaller, and the detection performance needs to be improved. To this end, using the similar median value to describe the accuracy of a group of data, an improved spectrum sensing algorithm based on the ratio of the maximum of the covariance matrix to the average of the similar median value is proposed. The proposed algorithm does not need the prior information and noise power of the authorized user signal, and the analytical representation of the decision threshold is derived. The simulation results under Gaussian channel show that the detection performance of the improved algorithm is significantly improved under low SNR.
DTMS: A Dual Trust-based Multi-level Sybil Attack Detection Approach in WSNs
Authors: KHAN Tayyab , Singh Karan 
Published: March 2023

Abstract
Sensor network has been proven a promising technology for discerning data as well as details about the physical world. The sensor nodes are organized and positioned in an inaccessible and hostile environment and are consequently susceptible to various security attacks. Among the multiple attacks possible in any WSN, the Sybil attack is the most severe kind of attack. Detection of a Sybil node is a complex as well as challenging problem since it illegitimately uses multiple fraudulent identities to misguide and collapse the network. The paper proposes a dual trust-based multi-level Sybil (DTMS) attack detection approach in WSNs. The work engages a multi-level detection system grounded on verification of the node’s identity and location. Later, at each level, CM, CH, and BS, the trust value is calculated. For a satisfactory level of trust value, communication trust is calculated together with data trust. The trust function of DTMS involves dynamic reward and penalty coefficient to ensure severity. Besides, data aggregation is employed, which contributes to lesser communication overhead and energy consumption. The performance evaluation of DTMS is measured in terms of severity of trust function, true detection rate, false detection rate, residual energy, network lifetime, and packet loss ratio. The simulation results validate that DTMS can efficaciously detect Sybil nodes. Experiment results show that the proposed algorithm can detect [[EQUATION]] of Sybil nodes in the malicious environment. Additionally, the DTMS is compared with recent existing schemes in terms of various parameters (True Detection Rate, False Detection Rate, energy consumption, packet loss rate, number of alive nodes, etc.) which show that the DTMS performs desirably.
Revisiting the Synthesis of Graphene Oxide: A New Insight into Reaction Kinetics
Authors: Gupta Ravi Kumar , Yadav Manishkumar D 
Published: March 2023

Abstract
Graphene oxide has become one of the most researched materials due to its extraordinary properties and promising applications. In literature, various top-down methods for synthesis of graphene oxide have been discussed which include mechanical, thermal and chemical exfoliation of graphite powder. However, kinetics study related to the synthesis of graphene oxide is reported scarcely. In the present work, graphene oxide was synthesized using Improved Hummer’s method to understand the kinetics of the formation of graphene oxide. Graphite particle size, stirring speed, concentrations of oxidants & intercalating agents and temperature were the parameters of focus in the present study. The apparent energy of activation was found to be 28.88 kJ mol− 1. In the characterization part various analytical techniques transmission electron microscopy, Raman spectroscopy, FT-IR, thermogravimetry and BET analysis have been carried out to study the characteristic features of graphene oxide.