bluuebunny/crossref_metadata_2025_split huggingface dataset:
Advances in New Zealand's Tephrochronostratigraphy Using Marine Drill Sites: The Neogene
Authors: Pank K. , Kutterolf S. , Hopkins J. L. , Wang K.‐L. , Lee H.‐Y. , Schmitt A. K. 
Published: July 2023

AbstractThree volcanic arcs have been the source of New Zealand's volcanic activity since the Neogene: Northland arc, Coromandel Volcanic Zone (CVZ) and Taupō Volcanic Zone (TVZ). The eruption chronology for the Quaternary, sourced by the TVZ, is well studied and established, whereas the volcanic evolution of the precursor arc systems, like the CVZ (central activity c. 18 to 2 Ma), is poorly known due to limited accessibility to, or identification of, onshore volcanic deposits and their sources. Here, we investigate the marine tephra record of the Neogene, mostly sourced by the CVZ, of cores from IODP Exp. 375 (Sites U1520 and U1526), ODP Leg 181 (Sites 1123, 1124 and 1125), IODP Leg 329 (Site U1371) and DSDP Leg 90 (Site 594) offshore of New Zealand. In total, we identify 306 primary tephra layers in the marine sediments. Multi‐approach age models (e.g. biostratigraphy, zircon ages) are used in combination with geochemical fingerprinting (major and trace element compositions) and the stratigraphic context of each marine tephra layer to establish 168 tie‐lines between marine tephra layers from different holes and sites. Following this approach, we identify 208 explosive volcanic events in the Neogene between c. 17.5 and 2.6 Ma. This is the first comprehensive study of New Zealand's Neogene explosive volcanism established from tephrochronostratigraphic studies, which reveals continuous volcanic activity between c. 12 and 2.6 Ma with an abrupt compositional change at c. 4.5 Ma, potentially associated with the transition from CVZ to TVZ.
Maternal perceived stress and infant behavior during the COVID-19 pandemic
Authors: Bradley Holly , Fine Dana , Minai Yasmin , Gilabert Laurel , Gregory Kimberly , Smith Lynne , Gao Wei , Giase Gina , Krogh-Jespersen Sheila , Zhang Yudong , Wakschlag Lauren , Brito Natalie H. , Feliciano Integra , Thomason Moriah , Cabral Laura , Panigrahy Ashok , Potter Alexandra , Cioffredi Leigh-Anne , Smith Beth A. 
Published: July 2023

Abstract
Background
Maternal stress has negative consequences on infant behavioral development, and COVID-19 presented uniquely stressful situations to mothers of infants born during the pandemic. We hypothesized that mothers with higher levels of perceived stress during the pandemic would report higher levels of infant regulatory problems including crying and interrupted sleep patterns.

Methods
As part 6 sites of a longitudinal study, mothers of infants born during the pandemic completed the Perceived Stress Scale, the Brief Infant Sleep Questionnaire, and an Infant Crying survey at 6 (n = 433) and 12 (n = 344) months of infant age.

Results
Maternal perceived stress, which remained consistent at 6 and 12 months of infant age, was significantly positively correlated with time taken to settle infants. Although maternal perceived stress was not correlated with uninterrupted sleep length, time taken to put the infant to sleep was correlated. Perceived stress was also correlated with the amount of infant crying and fussiness reported at 6 months.

Conclusions
Mothers who reported higher levels of perceived stress during the pandemic reported higher levels of regulatory problems, specifically at 6 months. Examining how varying levels of maternal stress and infant behaviors relate to overall infant developmental status over time is an important next step.

Impact
Women giving birth during the COVID-19 pandemic who reported higher levels of stress on the Perceived Stress Scale also reported higher levels of infant fussiness and crying at 6 months old, and more disruptive sleep patterns in their infants at 6 months and 12 months old. Sleeping problems and excessive crying in infancy are two regulatory problems that are known risk factors for emotional and behavioral issues in later childhood. This paper is one of the first studies highlighting the associations between maternal stress and infant behaviors during the COVID-19 pandemic.
Fine-grained topographic organization within somatosensory cortex during resting-state and emotional face-matching task and its association with ASD traits
Authors: Isakoglou Christina , Haak Koen V. , Wolfers Thomas , Floris Dorothea L. , Llera Alberto , Oldehinkel Marianne , Forde Natalie J. , Oakley Bethany F. M. , Tillmann Julian , Holt Rosemary J. , Moessnang Carolin , Loth Eva , Bourgeron Thomas , Baron-Cohen Simon , Charman Tony , Banaschewski Tobias , Murphy Declan G. M. , Buitelaar Jan K. , Marquand Andre F. , Beckmann Christian F. 
Published: July 2023

AbstractSensory atypicalities are particularly common in autism spectrum disorders (ASD). Nevertheless, our knowledge about the divergent functioning of the underlying somatosensory region and its association with ASD phenotype features is limited. We applied a data-driven approach to map the fine-grained variations in functional connectivity of the primary somatosensory cortex (S1) to the rest of the brain in 240 autistic and 164 neurotypical individuals from the EU-AIMS LEAP dataset, aged between 7 and 30. We estimated the S1 connection topography (‘connectopy’) at rest and during the emotional face-matching (Hariri) task, an established measure of emotion reactivity, and accessed its association with a set of clinical and behavioral variables. We first demonstrated that the S1 connectopy is organized along a dorsoventral axis, mapping onto the S1 somatotopic organization. We then found that its spatial characteristics were linked to the individuals’ adaptive functioning skills, as measured by the Vineland Adaptive Behavior Scales, across the whole sample. Higher functional differentiation characterized the S1 connectopies of individuals with higher daily life adaptive skills. Notably, we detected significant differences between rest and the Hariri task in the S1 connectopies, as well as their projection maps onto the rest of the brain suggesting a task-modulating effect on S1 due to emotion processing. All in all, variation of adaptive skills appears to be reflected in the brain’s mesoscale neural circuitry, as shown by the S1 connectivity profile, which is also differentially modulated during rest and emotional processing.
Li iontronics in single-crystalline T-Nb2O5 thin films with vertical ionic transport channels
Authors: Han Hyeon , Jacquet Quentin , Jiang Zhen , Sayed Farheen N. , Jeon Jae-Chun , Sharma Arpit , Schankler Aaron M. , Kakekhani Arvin , Meyerheim Holger L. , Park Jucheol , Nam Sang Yeol , Griffith Kent J. , Simonelli Laura , Rappe Andrew M. , Grey Clare P. , Parkin Stuart S. P. 
Published: July 2023

AbstractThe niobium oxide polymorph T-Nb2O5 has been extensively investigated in its bulk form especially for applications in fast-charging batteries and electrochemical (pseudo)capacitors. Its crystal structure, which has two-dimensional (2D) layers with very low steric hindrance, allows for fast Li-ion migration. However, since its discovery in 1941, the growth of single-crystalline thin films and its electronic applications have not yet been realized, probably due to its large orthorhombic unit cell along with the existence of many polymorphs. Here we demonstrate the epitaxial growth of single-crystalline T-Nb2O5 thin films, critically with the ionic transport channels oriented perpendicular to the film’s surface. These vertical 2D channels enable fast Li-ion migration, which we show gives rise to a colossal insulator–metal transition, where the resistivity drops by 11 orders of magnitude due to the population of the initially empty Nb 4d0 states by electrons. Moreover, we reveal multiple unexplored phase transitions with distinct crystal and electronic structures over a wide range of Li-ion concentrations by comprehensive in situ experiments and theoretical calculations, which allow for the reversible and repeatable manipulation of these phases and their distinct electronic properties. This work paves the way for the exploration of novel thin films with ionic channels and their potential applications.
On the simultaneous scattering of two photons by a single two-level atom
Authors: Masters Luke , Hu Xin-Xin , Cordier Martin , Maron Gabriele , Pache Lucas , Rauschenbeutel Arno , Schemmer Max , Volz Jürgen 
Published: July 2023

AbstractThe interaction of light with a single two-level emitter is the most fundamental process in quantum optics, and is key to many quantum applications. As a distinctive feature, two photons are never detected simultaneously in the light scattered by the emitter. This is commonly interpreted by saying that a single two-level quantum emitter can only absorb and emit single photons. However, it has been theoretically proposed that the photon anticorrelations can be thought of as arising from quantum interference between two possible two-photon scattering amplitudes, which one refers to as coherent and incoherent. This picture is in stark contrast to the aforementioned one, in that it assumes that the atom has two different mechanisms at its disposal to scatter two photons at the same time. Here we experimentally validate the interference picture by showing that, when spectrally rejecting only the coherent component of the fluorescence light of a single two-level atom, the remaining light consists of photon pairs that have been simultaneously scattered by the atom. Our results offer fundamental insights into the quantum-mechanical interaction between light and matter and open up novel approaches for the generation of highly non-classical light fields enabling, for example, Fourier-limited photon-pair sources that approach the theoretical limit in brightness.
Mesothelin-targeting T cell receptor fusion construct cell therapy in refractory solid tumors: phase 1/2 trial interim results
Authors: Hassan Raffit , Butler Marcus , O’Cearbhaill Roisin E. , Oh David Y. , Johnson Melissa , Zikaras Kevin , Smalley Munisha , Ross Michael , Tanyi Janos L. , Ghafoor Azam , Shah Nirali N. , Saboury Babak , Cao Liang , Quintás-Cardama Alfonso , Hong David 
Published: July 2023

AbstractThe T cell receptor fusion construct (TRuC) gavocabtagene autoleucel (gavo-cel) consists of single-domain anti-mesothelin antibody that integrates into the endogenous T cell receptor (TCR) and engages the signaling capacity of the entire TCR upon mesothelin binding. Here we describe phase 1 results from an ongoing phase1/2 trial of gavo-cel in patients with treatment-refractory mesothelin-expressing solid tumors. The primary objectives were to evaluate safety and determine the recommended phase 2 dose (RP2D). Secondary objectives included efficacy. Thirty-two patients received gavo-cel at increasing doses either as a single agent (n = 3) or after lymphodepletion (LD,n = 29). Dose-limiting toxicities of grade 3 pneumonitis and grade 5 bronchioalveolar hemorrhage were noted. The RP2D was determined as 1 × 108cells per m2after LD. Grade 3 or higher pneumonitis was seen in 16% of all patients and in none at the RP2D; grade 3 or higher cytokine release syndrome occurred in 25% of all patients and in 15% at the RP2D. In 30 evaluable patients, the overall response rate and disease control rate were 20% (13% confirmed) and 77%, respectively, and the 6-month overall survival rate was 70%. Gavo-cel warrants further study in patients with mesothelin-expressing cancers given its encouraging anti-tumor activity, but it may have a narrow therapeutic window. ClinicalTrials.gov identifier:NCT03907852.
Pedunculopontine Chx10+ neurons control global motor arrest in mice
Authors: Goñi-Erro Haizea , Selvan Raghavendra , Caggiano Vittorio , Leiras Roberto , Kiehn Ole 
Published: July 2023

AbstractArrest of ongoing movements is an integral part of executing motor programs. Behavioral arrest may happen upon termination of a variety of goal-directed movements or as a global motor arrest either in the context of fear or in response to salient environmental cues. The neuronal circuits that bridge with the executive motor circuits to implement a global motor arrest are poorly understood. We report the discovery that the activation of glutamatergic Chx10-derived neurons in the pedunculopontine nucleus (PPN) in mice arrests all ongoing movements while simultaneously causing apnea and bradycardia. This global motor arrest has a pause-and-play pattern with an instantaneous interruption of movement followed by a short-latency continuation from where it was paused. Mice naturally perform arrest bouts with the same combination of motor and autonomic features. The Chx10-PPN-evoked arrest is different to ventrolateral periaqueductal gray-induced freezing. Our study defines a motor command that induces a global motor arrest, which may be recruited in response to salient environmental cues to allow for a preparatory or arousal state, and identifies a locomotor-opposing role for rostrally biased glutamatergic neurons in the PPN.
Dynamics of soil organic carbon of jhum agriculture land-use system in the heterogeneous hill of Arunachal Pradesh, India
Authors: Kumar Jitendra , Kalita H. , Rekhung Wangnem , Alone Rajesh A. , Angami Thejangulie , Jini Doni , Makdoh Badapmain , Touthang Letngam , Khatri Nirmal , Singh A. P. , Sinha Nishant K. , Kumar Dhiraj , Chaudhary R. S. 
Published: July 2023

AbstractLand-use conversion affects soil organic carbon (SOC) dynamics. Therefore, an in-depth study of change in SOC, SOC pool, fractions of SOC and enzymatic activities of soil microbial biomass carbon (SMBC) and dehydrogenase (DHA) with the conversion of forest land to jhum, fallow jhum and settle cultivation use has been undertaken on the hills of Arunachal Pradesh of India. Geo-referenced soil samples from eight different locations, each from different land uses were collected at three depth. One part of the soil sample had been used for the analysis of SOC and its carbon fraction. The second portion was kept in a deep freezer for determining SMBC and DHA. The third part was used for the analysis of bulk density. The result revealed that the highest loss of SOC pool was recorded in jhum land (41.8 to 13.4%), and the labile carbon was also found to decrease in jhum land. The highest SMBC was observed on the surface soil of the natural forest; the highest DHA was found in the natural forest; and the lowest DHA was recorded in jhum land. This study found that the converting natural forest to jhum reduces SOC storage, enzymatic activities and C fractions significantly whereas fallow jhum shows sign of recovery because all of these parameters improved when compared to the jhum land-use system. This study also confirms that the fallow period helps restore the initial situation.
Short-term effects of occlusion therapy and optical correction on microvasculature in monocular amblyopia: a retrospective case–control study
Authors: Kim Jae-Gon , Lee Se Youp , Lee Dong Cheol 
Published: July 2023

AbstractThis retrospective longitudinal case–control study investigated the short-term effects of patch occlusion treatment compared with optical correction on the microvasculature in monocular amblyopia. We included patients with monocular amblyopia treated for 2–12 months; they were classified into two groups according to the treatment regimen: patch occlusion or optical correction. Children aged < 12 years who presented to our clinic for examination without amblyopia diagnosis were enrolled as the control group. Changes in retinal and choroid microvasculature according to treatment were examined, and the correlation between changes in microvasculature and improvement in best-corrected visual acuity (BCVA) was evaluated. There were 57, 35, and 41 patients in the patch occlusion, optical correction, and control groups, respectively (mean age, 6.4 ± 2.0 years). Both amblyopic groups showed changes in the foveal and parafoveal deep capillary plexus vessel density (DCPD), choroidal thickness, and choroidal vascularity index (CVI) following short-term treatment (mean, 4.5 months). In the patch occlusion group, BCVA improved as the foveal DCPD increased (P = 0.013) and the CVI decreased (P = 0.037). In the optical correction group, BCVA improved as the foveal and parafoveal DCPD increased (P = 0.009). Increased foveal DCPD following amblyopia treatment and decreased CVI by patch occlusion were associated with improved BCVA.
A recombinant Aspergillus oryzae fungus transmitted from larvae to adults of Anopheles stephensi mosquitoes inhibits malaria parasite oocyst development
Authors: Kianifard Leila , Rafiqi Ab. Matteen , Akcakir Osman , Aly Ahmed S. I. , Billingsley Peter F. , Uysal Serdar 
Published: July 2023

AbstractThe control of malaria parasite transmission from mosquitoes to humans is hampered by decreasing efficacies of insecticides, development of drug resistance against the last-resort antimalarials, and the absence of effective vaccines. Herein, the anti-plasmodial transmission blocking activity of a recombinant Aspergillus oryzae (A. oryzae-R) fungus strain, which is used in human food industry, was investigated in laboratory-reared Anopheles stephensi mosquitoes. The recombinant fungus strain was genetically modified to secrete two anti-plasmodial effector peptides, MP2 (midgut peptide 2) and EPIP (enolase-plasminogen interaction peptide) peptides. The transstadial transmission of the fungus from larvae to adult mosquitoes was confirmed following inoculation of A. oryzae-R in the water trays used for larval rearing. Secretion of the anti-plasmodial effector peptides inside the mosquito midguts inhibited oocyst formation of P. berghei parasites. These results indicate that A. oryzae can be used as a paratransgenesis model carrying effector proteins to inhibit malaria parasite development in An. stephensi. Further studies are needed to determine if this recombinant fungus can be adapted under natural conditions, with a minimal or no impact on the environment, to target mosquito-borne infectious disease agents inside their vectors.
Cool executive functions and their association with body mass & fatness and the FTO gene in school-aged children
Authors: Szcześniewska Paula , Bryl Ewa , Dutkiewicz Agata , Borkowska Aneta R. , Bilska Karolina , Paszyńska Elżbieta , Słopień Agnieszka , Dmitrzak-Węglarz Monika , Hanć Tomasz 
Published: July 2023

AbstractThe FTO gene rs9936909 polymorphism is one of the well-documented single nucleotide polymorphisms in the context of increased risk of obesity, including in children. Few studies have tested the association of the FTO gene with cognitive functions. Deficits of “cool” executive functions (EFs) are considered a potential risk factor for excessive weight. The aims of our study were to investigate whether cool EFs are associated with the Body Mass Index, the Fat Mass Index and the risk of excess body mass and overfatness in neurotypically school-aged children, and whether the FTO gene polymorphism is involved in development of this possible association. The sample consisted of 553 children aged 6–12 years old. A body composition analysis, a neuropsychological assessment of EFs, and FTO polymorphism genotyping were performed in the children studied. The study found a significant association of an interference effect in theStroop Color-Word Interference Task and the risk of excessive body fatness, but not excessive body mass. There were no explicit associations between the FTO genotype and EFs deficits. Environmental factors, and particularly low maternal education, appeared to be the strongest contributors to the increased risk of obesity.
IoT-based data-driven predictive maintenance relying on fuzzy system and artificial neural networks
Authors: Aboshosha Ashraf , Haggag Ayman , George Neseem , Hamad Hisham A. 
Published: July 2023

AbstractIndustry 4.0 technologies need to plan reactive and Preventive Maintenance (PM) strategies for their production lines. This applied research study aims to employ the Predictive Maintenance (PdM) technology with advanced automation technologies to counter all expected maintenance problems. Moreover, the deep learning based AI is employed to interpret the alarming patterns into real faults by which the system minimizes the human based fault recognition errors. The Sensors Information Modeling (SIM) and the Internet of Things (IoT) have the potential to improve the efficiency of industrial production machines maintenance management. This research work provides a better maintenance strategy by utilizing a data-driven predictive maintenance planning framework based on our proposed SIM and IoT technologies. To verify the feasibility of our approach, the proposed framework is applied practically on a corrugated cardboard production factory in real industrial environment. The Fuzzy Logic System (FLS) is utilized to achieve the AI based PM while the Deep Learning (DL) is applied for the alarming and fault diagnosis in case the fault already occured.
Soil phosphorous is the primary factor determining species-specific plant growth depending on soil acidity in island ecosystems with severe erosion
Authors: Hata Kenji , Hiradate Syuntaro , Kachi Naoki 
Published: July 2023

AbstractDisturbances caused by invasive ungulates alter soil environments markedly and can prevent ecosystem recovery even after eradication of the ungulates. On oceanic islands, overgrazing and trampling by feral goats has caused vegetation degradation and soil erosion, which can alter soil chemistry. To understand the effects of the changes on plant performance, we conducted a laboratory experiment to assess herbaceous species growth under various soil conditions with phosphorous, nutrients, and acidity. Subsoil was collected from Nakodo-jima in the northwest Pacific. Six herbaceous species dominating the island were grown in soils with three levels of added CaCO3 and P2O5 and two levels of added KNO3. After 4 weeks of growth, the total dry plant weight was significantly lower with no added P2O5, regardless of the addition of KNO3. Three species weighed more under P2O5 and KNO3 addition in high-pH soil, whereas the remaining three weighed less. Our results indicated that herbaceous species growth is limited primarily by phosphorous availability; the limitation is dependent on soil pH, and the trend of dependency differs among species. This implies that ecosystems with extreme disturbances cannot recover without improving the soil chemistry.
Impact of delivery time factor on treatment time and plan quality in tomotherapy
Authors: Yagihashi Takayuki , Inoue Tatsuya , Shiba Shintaro , Yamano Akihiro , Minagawa Yumiko , Omura Motoko , Inoue Kazumasa , Nagata Hironori 
Published: July 2023

AbstractDelivery time factor (DTF) is a new parameter introduced by the RayStation treatment planning system for tomotherapy treatment planning. This study investigated the effects of this factor on various tomotherapy plans. Twenty-five patients with cancer (head and neck, 6; lung, 9; prostate, 10) were enrolled in this study. Helical tomotherapy plans with a field width of 2.5 cm, pitch of 0.287, and DTF of 2.0 were created. All the initial plans were recalculated by changing the DTF parameter from 1.0 to 3.0 in increments of 0.1. Then, DTF’s impact on delivery efficiency and plan quality was evaluated. Treatment time and modulation factor increased monotonically with increasing DTF. Increasing the DTF by 0.1 increased the treatment time and modulation factor by almost 10%. This relationship was similar for all treatment sites. Conformity index (CI), homogeneity index, and organ at risk doses were improved compared to plans with a DTF of 1.0, except for the CI in the lung cancer case. However, the improvement in most indices ceased at a certain DTF; nevertheless, treatment time continued to increase following an increase in DTF. DTF is a critical parameter for improving the quality of tomotherapy plans.