bluuebunny/crossref_metadata_2025_split huggingface dataset:
Study on time–space characteristics of gas drainage in advanced self‐pressure‐relief area of the stope
Authors: Jie Xi , Zhaofeng Wang , Dongdong Chen , Jinsheng Chen 
Published: January 2023

AbstractGas drainage is an important measure to ensure energy safety in coal mines. However, for mines with high gas content and low permeability, the critical question is how to enhance the drainage effect of drilling. By using the self‐unloading pressure effect on the coal body in front of the mine, the permeability of the coal body can be improved, which facilitates gas drainage. Therefore, establishing the fluid–solid model of gas‐bearing coal mass under the influence of mining, this paper simulates the advanced self‐pressure‐relief range in front of the coal working face and the permeability of coal seam at different heights. Through simulations and field tests, the reasonableness of the advanced self‐pressure‐relief gas drainage was verified, and the spatial and temporal characteristics of the gas drainage from the borehole were quantified and analyzed. The results show that the width of the advanced self‐pressure‐relief zone after simulated mining is 25 m, the vertical permeability of the coal seam increases first and then decreases with the increase of the height from the floor, and the maximum permeability of the layer is 2.6 m from the floor, which is 8.62 times higher than the initial permeability; the gas drainage effect of test boreholes has a periodic law with the coal seam recovery, which, divided into the initial drainage stage, the scalar volume of gas drainage increase stage, and the scalar volume of gas drainage decay stage. At a distance from the working face 20–40 m, the boreholes' scalar volume of gas drainage increased by 3.89 times compared with the initial drainage stage, and the scalar drainage volume of the boreholes through the seam increased by 8.01 times compared with the initial drainage stage; in the section of increasing scalar volume of drainage, the gas drainage volume of the boreholes at different heights of the coal seam had obvious “stratification” phenomenon. The test boreholes were optimally placed in the middle of the seam at the lower end. The study provides a reference for self‐pressure‐relief gas drainage technology and optimization of borehole placement.
Distinguishing depositional environments in the beach–dune system of Chandipur, India, based on sediment texture and quartz grain surface features
Authors: Saha Koushik , Sinha Subhajit 
Published: January 2023

AbstractAn attempt has been made to discern sedimentary environments in a tropical coastal setting in Chandipur, India, using variations in grain size. Samples were collected along one 100 m‐long cross‐shore transect extending from the tide/aqueous‐influenced seaward region to the aeolian‐dominated landward region. Various grain size data analysis approaches, like bivariate data plots and discrimination functions, were used to discriminate the sedimentary environments and establish the process of sediment deposition. The analytical results suggest that diverse granulometric parameters translate different sedimentary environments such as tidal flat, beach and dune. Additionally, the surface morphologies of quartz grains were used to understand the evolution of recent mechanical, chemical and mechanical–chemical processes in this tropical coastal region. Changes in the surficial microtextural properties of quartz grains were documented at various sites of all geomorphic units along this transect, from the tidal flat to the dune. One‐way analysis of variance (ANOVA) was used to understand the significant differences in microtextural features between these units. Subaqueous surface textures such as large conchoidal fractures, sharp edges, arcuate steps and straight and curved grooves were dominant in the grains of the tidal flat. The presence of meandering ridges, upturned plates, bulbous edges and adhering particles on quartz gradually increases as the transect ascends landward. Correlation plots between distance and microtextures, along with ANOVA, suggest that aeolian transportation modulated the surface textures. Such assessment of distinct sedimentary characteristics and transport processes may serve as a modern analogue for ancient deposits on the siliciclastic coast.
Predicting probabilities of late summer surface flow presence in a glaciated mountainous headwater region
Authors: Jaeger Kristin L. , Sando Roy , Dunn Sarah B. , Gendaszek Andrew S. 
Published: January 2023

AbstractAccurate mapping of streams that maintain surface flow during annual baseflow periods in mountain headwater streams is important for informing water availability for human consumption and is a fundamental determinant of in‐channel conditions for stream‐dwelling organisms. Yet accurate mapping that captures local spatial variability and associated local controls on surface flow presence is limited. An empirical random‐forest model was developed to predict streamflow permanence (late summer surface‐flow presence) for Mount Rainier National Park and the surrounding mountainous area in western Washington, USA. This model was developed to improve upon the existing multi‐state, regional‐scale probability of stream permanence developed for the greater Pacific Northwest Region (PROSPERPNW). The model was trained on 544 wet/dry observations collected during the late summer, baseflow period from 2018 to 2020 using the crowd‐source mobile application, FLOwPER. Final model accuracy was 0.74 with drainage area and covariates describing geology, topography, and land cover as top predictors of streamflow permanence compared to coarser resolution climatic covariates. The prevalence of static covariates over climatic covariates as top ranked important covariates highlights the importance of scale when evaluating controls on streamflow permanence. Cross validation of the model indicates that streamflow permanence probabilities from this model is an improvement over the regional‐scale PROSPERPNW model demonstrating the utility of relatively simple, crowd‐sourced data to address water resource needs, and that determination of important predictors of streamflow permanence is influenced by the spatial and temporal resolution of analysis.
A nuanced look into youth journeys of gender transition and detransition
Authors: Pullen Sansfaçon Annie , Gelly Morgane A. , Gravel Rosalie , Medico Denise , Baril Alexandre , Susset Françoise , Paradis August 
Published: January 2023

AbstractSome media have suggested that many youths who have previously completed a gender transition are “detransitioning”. Their experience is often framed around the idea of regrets but rare are the articles that provide a nuanced examination of their journey. This article presents the perspectives of youths who have detransitioned or discontinued a transition regarding their experiences and feelings on their journey from transition to detransition. Semi‐structured interviews were conducted with 20 youths between the age of 16 and 25 years who were recruited on social media and who transitioned and detransitioned or discontinued their transition. Data were analysed according to thematic analysis. Regrets and feelings of satisfaction can both coexist. The processes of transition and discontinuation or detransition appear to be non‐linear and participants do not necessarily return to a cisgender identity. Ambiguous loss theory is applied to frame youth experiences and feelings and to suggest way forward for intervention.Highlights
This paper examines the experiences and feelings of youth on their journey from transition to detransition.
Their journey is experienced as non‐linear, and often comprised mixed feelings and experiences about transition and detransition steps.
Ambiguous loss theory allows a nuanced understanding of feelings and experiences of their journey from transition to detransition.
Angiotensin converting enzyme 2 activation improves allergic rhinitis and suppresses Th2 cytokine release
Authors: Sun Xiuying , Xu Yu , Zhou Jinhui 
Published: January 2023

AbstractObjectiveAllergic rhinitis (AR) is primarily regulated by type I hypersensitivity, with Th2 and immunoglobulin E (IgE) playing essential roles. This study aimed to determine whether angiotensin converting enzyme (ACE)2 could participate in the regulation of AR.MethodsNasal mucosal tissues of AR patients were collected to determine ACE2 levels. Following AR mouse models were established, ACE2 levels in nasal mucosa were determined. Then the influences of diminazene aceturate (ACE2 agonist) on AR symptoms, pathology, specific antibodies, histamine, and interleukins (ILs) release in vivo were evaluated. Afterward, human nasal mucosa epithelial cells were exposed to IL‐13, and the impacts of ACE2 overexpression on the secretion of pro‐inflammatory factors in vitro were assessed.ResultsACE2 levels significantly declined in nasal mucosa both in patients and mouse models (p < .001). Diminazene aceturate treatment elevated the ACE2 level in mice (p < .01), accompanied by reduced frequency of nasal spray and nasal friction, decreased eosinophils and goblet cells (p < .001) according to histopathological staining. Furthermore, lgE, lgG1, histamine, and IL levels in mice were also decreased (p < .05). In vitro experiments revealed that ACE2 overexpression suppressed the secretion of pro‐inflammatory factors (p < .001).ConclusionTogether, ACE2 activation can alleviate the symptoms of AR in mice and inhibit the release of Th2 cytokines. Activating ACE2 is a promising therapeutic approach for AR.
Noninvasive detection of microsatellite instability in patients with endometrial cancer
Authors: Casas‐Arozamena Carlos , Moiola Cristian Pablo , Vilar Ana , Bouso Marta , Cueva Juan , Cabrera Silvia , Sampayo Victoria , Arias Efigenia , Abalo Alicia , García Ángel , Lago‐Lestón Ramón Manuel , Oltra Sara , Díaz Eva , Ruiz‐Bañobre Juan , López‐López Rafael , Moreno‐Bueno Gema , Gil‐Moreno Antonio , Colás Eva , Abal Miguel , Muinelo‐Romay Laura 
Published: January 2023

AbstractThe analysis of mismatch repair proteins in solid tissue is the standard of care (SoC) for the microsatellite instability (MSI) characterization in endometrial cancer (EC). Uterine aspirates (UAs) or circulating‐DNA (cfDNA) samples capture the intratumor heterogeneity and provide a more comprehensive and dynamic molecular diagnosis. Thus, MSI analysis by droplet‐digital PCR (ddPCR) in UAs and cfDNA can provide a reliable tool to characterize and follow‐up the disease. The UAs, paraffin‐embedded tumor tissue (FFPE) and longitudinal plasma samples from a cohort of 90 EC patients were analyzed using ddPCR panel and compared to the SoC. A high concordance (96.67%) was obtained between the analysis of MSI markers in UAs and the SoC. Three discordant cases were validated as unstable by ddPCR on FFPE samples. Besides, a good overall concordance (70.27%) was obtained when comparing the performance of the ddPCR assay on UAs and cfDNA in high‐risk tumors. Importantly, our results also evidenced the value of MSI analysis to monitor the disease evolution. MSI evaluation in minimally invasive samples shows great accuracy and sensitivity and provides a valuable tool for the molecular characterization and follow‐up of endometrial tumors, opening new opportunities for personalized management of EC.
The rapid growth of cryptocurrencies: How profitable is trading in digital money?
Authors: Manahov Viktor 
Published: January 2023

AbstractThere has been a tremendous growth in cryptocurrencies, which has challenged policy makers around the globe. We obtain millisecond data of some of the most frequently traded cryptocurrencies – bitcoin, ethereum, ripple, litecoin and dash – and two cryptocurrency indices – CRIX and CCI30 – to examine their profitability. Our profitability findings suggest that cryptocurrency traders generate significant profits after considering reasonable transaction costs. We also observe that cryptocurrency market participants can expand and sustain the levels of profitability levels in the subsequent trading activity. Our robustness checks with more recent post‐Covid data are consistent with the initial profitability findings, although we observe lower levels of profits for the two indices and weaker profit persistency for all digital assets.
Changes in Distal Tibial Microarchitecture During Eight Weeks of U.S. Army Basic Combat Training Differ by Sex and Race
Authors: Hughes Julie M. , Taylor Kathryn M. , Guerriere Katelyn I. , Smith Nathaniel I. , Staab Jeffery S. , Walker Leila A. , Staab Janet E. , Bartlett Paul M. , Spiering Barry A. , Nguyen Vy T. , Proctor Susan P. , Foulis Stephen A. , Bouxsein Mary L. , Popp Kristin L. 
Published: January 2023

ABSTRACTBasic combat training (BCT) is a physically rigorous period at the beginning of a soldier's career that induces bone formation in the tibia. Race and sex are determinants of bone properties in young adults but their influences on changes in bone microarchitecture during BCT are unknown. The purpose of this work was to determine the influence of sex and race on changes in bone microarchitecture during BCT. Bone microarchitecture was assessed at the distal tibia via high‐resolution peripheral quantitative computed tomography at the beginning and end of 8 weeks of BCT in a multiracial cohort of trainees (552 female, 1053 male; mean ± standard deviation [SD] age = 20.7 ± 3.7 years) of which 25.4% self‐identified as black, 19.5% as race other than black or white (other races combined), and 55.1% as white. We used linear regression models to determine whether changes in bone microarchitecture due to BCT differed by race or sex, after adjusting for age, height, weight, physical activity, and tobacco use. We found that trabecular bone density (Tb.BMD), thickness (Tb.Th), and volume (Tb.BV/TV), as well as cortical BMD (Ct.BMD) and thickness (Ct.Th) increased following BCT in both sexes and across racial groups (+0.32% to +1.87%, all p < 0.01). Compared to males, females had greater increases in Tb.BMD (+1.87% versus +1.40%; p = 0.01) and Tb.Th (+0.87% versus +0.58%; p = 0.02), but smaller increases in Ct.BMD (+0.35% versus +0.61%; p < 0.01). Compared to black trainees, white trainees had greater increases in Tb.Th (+0.82% versus +0.61%; p = 0.03). Other races combined and white trainees had greater increases in Ct.BMD than black trainees (+0.56% and + 0.55% versus +0.32%; both p ≤ 0.01). Changes in distal tibial microarchitecture, consistent with adaptive bone formation, occur in trainees of all races and sexes, with modest differences by sex and race. Published 2023. This article is a U.S. Government work and is in the public domain in the USA. JBMR Plus published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research.
Macrophages and Bone Remodeling
Authors: Weivoda Megan M , Bradley Elizabeth W 
Published: January 2023

ABSTRACTBone remodeling in the adult skeleton facilitates the removal and replacement of damaged and old bone to maintain bone quality. Tight coordination of bone resorption and bone formation during remodeling crucially maintains skeletal mass. Increasing evidence suggests that many cell types beyond osteoclasts and osteoblasts support bone remodeling, including macrophages and other myeloid lineage cells. Herein, we discuss the origin and functions for macrophages in the bone microenvironment, tissue resident macrophages, osteomacs, as well as newly identified osteomorphs that result from osteoclast fission. We also touch on the role of macrophages during inflammatory bone resorption. © 2023 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research (ASBMR).
Umbelliferone attenuates diabetic cardiomyopathy by suppression of JAK/STAT signaling pathway through amelioration of oxidative stress and inflammation in rats
Authors: Khadrawy Sally M. , El Sayed Rasha A. 
Published: January 2023

AbstractUmbelliferone (UMB), 7‐hydroxycoumarin, is a naturally occurring coumarin derivative that has a plethora of biological and therapeutic activities. The focus of this research was to elucidate the curative effects of two different doses of UMB on diabetic cardiomyopathy (DCM) in a type 2 diabetic rat model induced by 50 mg/kg body weight of streptozotocin (STZ). Diabetic rats orally received 10 or 30 mg/kg of UMB daily for 8 weeks. Compared to the nontreated diabetic group, both UMB treatment doses significantly decreased glucose levels, glycated hemoglobin (HbA1c), tumor necrosis factor alpha (TNF‐α), interleukin‐6 (IL‐6), creatine kinase MB (CK‐MB), cardiovascular risk indices, and oxidative stress by reducing malondialdehyde (MDA) and increasing the activity of the antioxidant enzymes. The hypercholesterolemia and hypertriglyceridemia also dramatically decreased in diabetic groups with UMB treatments accompanied by an improvement in insulin, and insulin sensitivity indices (HOMA‐IR and QUICKI). Furthermore, the cardiac gene expressions and protein levels of Janus kinase2 (JAK2), signal transducer and activator of transcription3 (STAT3), and transforming growth factor beta1 (TGF‐β1) were also markedly downregulated in a dose‐dependent manner by UMB treatments. Finally, the biochemical results were assured by the reduction of histological alterations in cardiac tissues. In conclusion, UMB is a propitious substance for the treatment of DCM by virtuousness of its antihyperglycemic, antihyperlipidemic, antioxidant, and anti‐inflammatory properties through modulating the JAK/STAT signaling pathway that may be the underlying mechanism in UMB action.
Applying an intersectional lens to addressing gender disparities and disadvantage in rural Melanesian agriculture
Authors: Addinsall Cherise , Rihai Norah , Andre Brenda , Addinsall Eva , Dunphy Mia , Van der Wildenberg Brooke , Nelson Anjali , Weir Tasha 
Published: January 2023

AbstractAgricultural research and development projects face structural barriers to the equitable participation of women. Applying an intersectional approach can facilitate women to freely pursue their economic, social and cultural development within the existing patriarchal and colonial structures, ultimately challenging and subverting these structures. This paper argues that development initiatives must seek to understand the ways of being within specific localised projects, to tailor support and mitigate disadvantage. Through an exploration of two female‐led agroforestry projects in Vanuatu and Fiji, this paper demonstrates how centring the sovereignty of women over their own experience and livelihood aspirations can lead to familial, community and regional wellbeing.
MOGS‐CDG: Quantitative analysis of the diagnostic Glc3Man tetrasaccharide and clinical spectrum of six new cases
Authors: Post Merel A. , de Wit Isis , Zijlstra Fokje S. M. , Engelke Udo F. H. , van Rooij Arno , Christodoulou John , Tan Tiong Yang , Le Fevre Anna , Jin Danqun , Yaplito‐Lee Joy , Lee Beom Hee , Low Karen J. , Mallick Andrew A. , Õunap Katrin , Pitt James , Reardon William , Vals Mari‐Anne , Wortmann Saskia B. , Wessels Hans J. C. T. , Bärenfänger Melissa , van Karnebeek Clara D. M. , Lefeber Dirk J. 
Published: January 2023

AbstractCongenital disorders of glycosylation (CDG) are a clinically and biochemically heterogeneous subgroup of inherited metabolic disorders. Most CDG with abnormal N‐glycosylation can be detected by transferrin screening, however, MOGS‐CDG escapes this routine screening. Combined with the clinical heterogeneity of reported cases, diagnosing MOGS‐CDG can be challenging. Here, we clinically characterize ten MOGS‐CDG cases including six previously unreported individuals, showing a phenotype characterized by dysmorphic features, global developmental delay, muscular hypotonia, and seizures in all patients and in a minority vision problems and hypogammaglobulinemia. Glycomics confirmed accumulation of a Glc3Man7GlcNAc2 glycan in plasma. For quantification of the diagnostic Glcα1‐3Glcα1‐3Glcα1‐2Man tetrasaccharide in urine, we developed and validated a liquid chromatography‐mass spectrometry method of 2‐aminobenzoic acid (2AA) labeled urinary glycans. As an internal standard, isotopically labeled 13C6‐2AA Glc3Man was used, while labeling efficiency was controlled by use of 12C6‐2AA and 13C6‐2AA labeled laminaritetraose. Recovery, linearity, intra‐ and interassay coefficients of variability of these labeled compounds were determined. Furthermore, Glc3Man was specifically identified by retention time matching against authentic MOGS‐CDG urine and compared with Pompe urine. Glc3Man was increased in all six analyzed cases, ranging from 34.1 to 618.0 μmol/mmol creatinine (reference <5 μmol). In short, MOGS‐CDG has a broad manifestation of symptoms but can be diagnosed with the use of a quantitative method for analysis of urinary Glc3Man excretion.
Fractionated plasma N‐glycan profiling of novel cohort of ATP6AP1‐CDG subjects identifies phenotypic association
Authors: Alharbi Hana , Daniel Earnest James Paul , Thies Jenny , Chang Irene , Goldner Dana L. , Ng Bobby G. , Witters Peter , Aqul Amal , Velez‐Bartolomei Frances , Enns Gregory M. , Hsu Evelyn , Kichula Elizabeth , Lee Esther , Lourenco Charles , Poskanzer Sheri A. , Rasmussen Sara , Saarela Katelyn , Wang YunZu M. , Raymond Kimiyo M. , Schultz Matthew J. , Freeze Hudson H. , Lam Christina , Edmondson Andrew C. , He Miao 
Published: January 2023

AbstractATP6AP1‐CDG is an X‐linked disorder typically characterized by hepatopathy, immunodeficiency, and an abnormal type II transferrin glycosylation pattern. Here, we present 11 new patients and clinical updates with biochemical characterization on one previously reported patient. We also document intrafamilial phenotypic variability and atypical presentations, expanding the symptomatology of ATP6AP1‐CDG to include dystonia, hepatocellular carcinoma, and lysosomal abnormalities on hepatic histology. Three of our subjects received successful liver transplantation. We performed N‐glycan profiling of total and fractionated plasma proteins for six patients and show associations with varying phenotypes, demonstrating potential diagnostic and prognostic value of fractionated N‐glycan profiles. The aberrant N‐linked glycosylation in purified transferrin and remaining plasma glycoprotein fractions normalized in one patient post hepatic transplant, while the increases of Man4GlcNAc2 and Man5GlcNAc2 in purified immunoglobulins persisted. Interestingly, in the single patient with isolated immune deficiency phenotype, elevated high‐mannose glycans were detected on purified immunoglobulins without glycosylation abnormalities on transferrin or the remaining plasma glycoprotein fractions. Given the diverse and often tissue specific clinical presentations and the need of clinical management post hepatic transplant in ATP6AP1‐CDG patients, these results demonstrate that fractionated plasma N‐glycan profiling could be a valuable tool in diagnosis and disease monitoring.