bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence and Effects of Late Cardiotoxicity induced by Anthracyclines and/or Anti- HER2 Antibodies in Patients with Breast Cancer: a real world study
Authors: Oliveira Cátia , Flores Rui , Azevedo Raquel , Fontes Raquel , Pereira Vitor Hugo 
Published: July 2023

Abstract
Introduction: Breast cancer (BC) is the most frequently diagnosed cancer and the leading cause of cancer-related mortality in women. Advances in screening and treatment have improved survival but have also increased morbidity and mortality due to treatment side effects, particularly cardiotoxicity. Late cardiotoxicity generally develops several years after treatment. The risk of cardiotoxicity post BC treatment is increased by cardiovascular (CV) risk factors and previous cardiac disease. Nevertheless, limited data is available about the long-term effects of cardiotoxic treatment in women without CV risk factors before BC diagnosis.
Aims: To assess prevalence and long-term effects of late cardiotoxicity in a low-risk group of BC survivors.
Methods: This prospective study evaluated women aged between 18–65 years, diagnosed with non-metastatic BC and treated between 2011–2016 at a single institution The echocardiographic parameters were compared to an age-matched control group of women recently diagnosed with BC who have not been submitted to anticancer therapy.
Results: Among the 40 recruited women, 32.5% displayed left ventricular systolic dysfunction (LVSD) and 10% fulfilled criteria for late cardiotoxicity based on their previously recorded imaging parameters. There was a significant difference in left ventricular ejection fraction (LVEF) between time points (p < .001). The study group had significant lower LVEF compared to the control group, (p < .001). Additionally, there was a significant reduction in Global Longitudinal Strain in the study group when compared to controls, (p < .001).
Conclusions: In conclusion, this study demonstrated that cancer therapy related cardiac disease is a common side effect in BC survivors. Given this finding, even women without previous CV risk factors should be carefully monitored years after the end of treatment.
Impact of D2 total gastrectomy including splenectomy for scirrhous gastric cancer in the era of effective adjuvant chemotherapy
Authors: Yamagata Yukinori , Yoshikawa Takaki , Sakon Ryota , Ishizu Kenichi , Wada Takeyuki , Hayashi Tsutomu 
Published: July 2023

Abstract

Background
Total gastrectomy with D2 dissection including splenectomy (TGS) is usually selected for locally resectable scirrhous gastric cancer (SGC), which was established in the era of surgery alone. However, it remains unclear whether TGS for SGC is justified in the era of effective adjuvant chemotherapy.
Methods
This study included 120 SGC patients, consisting of 63 cases treated between January 2000 and December 2006 (Former group), and 57 cases treated between January 2007 and December 2016 (Latter group). We collected clinicopathological data, then examined survival and the therapeutic value index.
Results
The background characteristics were well-balanced, except for age and sex. The Latter group might be characterized by older population (P = 0.051) and frequent female (P = 0.067). Adjuvant chemotherapy was administered to 82.5% of the Latter group and was 15.9% in the Former group (P < 0.001). The 5-year overall survival rate of the Latter group was 57.9% (95% confidence interval: 43.2–70.0), seems better than that of the Former group (44.0%, 95% confidence interval: 31.5–55.8) (hazard ratio = 0.735, P = 0.221). Improvement of the index from the Former group was observed in the Latter group at almost all stations. The ratio of the index between these two groups was 1.38 at the D1 station and 1.60 at the D2 station. Index of splenic hilar node ranked similarly high in the both groups.
Conclusion
The therapeutic value index was improved in almost all nodal stations by S-1 adjuvant chemotherapy, especially in D2 nodes. TGS would be more important for locally resectable SGC in the era of effective adjuvant chemotherapy.
Serum glypican-4 and clusterin are increased and associated with insulin resistance in patients with polycystic ovary syndrome
Authors: Chen Zheng , Zeng Haixia , Huang Qiulan , Lin Cuiping , Li Xuan , Sun Shaohua , Liu Jianping 
Published: July 2023

Abstract
Objective:
To investigate the changes in serum glypican-4 (GPC4) and clusterin (CLU) levels in patients with polycystic ovary syndrome (PCOS) as well as their correlation with sex hormones and metabolic parameters.
Method:
A total of 40 PCOS patients and 40 age-matched healthy women during the same period were selected. To detect and compare serum GPC4 and CLU levels between the two groups, binary logistic regression was used to analyze the relative risk of PCOS at different levels of serum GPC4 and CLU. Stepwise linear regression was used to analyze the influential factors of serum GPC4 and CLU in PCOS patients.
Results:
Serum GPC4 (1.82 ± 0.49 vs. 1.30 ± 0.61 ng/ml, P < 0.001) and CLU (468.79 ± 92.85 vs. 228.59 ± 82.42 µg/ml, P < 0.001) in PCOS patients were significantly higher than those in healthy women. In the PCOS group, serum GPC4 was positively correlated with FSH, FPG, FINS, HOMA-IR, TG, and CLU (P < 0.05), whereas serum CLU was positively correlated with BMI, FPG, FINS, and HOMA-IR (P < 0.05), multiple stepwise linear regression analysis showed that HOMA-IR was independently associated with serum GPC4, and it showed that BMI and HOMA-IR were independently associated with CLU (P < 0.05).
Conclusion:
Serum GPC4 and CLU levels in PCOS patients were significantly higher than those in healthy women, suggesting that GPC4 and CLU may be markers associated with insulin resistance in women with PCOS.
Treatment outcomes for idiopathic sudden sensorineural hearing loss in dialysis patients
Authors: Kim Seonju , Lee Dong Kyu , Kim Hae-rim , Park Jung Mee , Kim Soon Bae , Yu Hoon 
Published: July 2023

Abstract
Idiopathic sudden sensorineural hearing loss (ISSNHL) poses a significant challenge for nephrologists in the treatment of dialysis patients. Due to limited studies comparing the treatment response between dialysis and non-dialysis patients, physicians face difficulties in managing this patient population. Therefore, this study aimed to investigate the treatment outcomes of dialysis patients with ISSNHL. This single-center, retrospective, observational study enrolled 700 patients diagnosed with ISSNHL between January 2005 and December 2021 at Asan Medical Center, Korea. Among them, 47 were dialysis patients, while 653 were non-dialysis patients. To balance pre-existing clinical characteristics, a 1:5 propensity score matching analysis was performed on the non-dialysis patients. The standard protocol involved administering high-dose systemic steroid therapy or intra-tympanic steroid injections. The pure tone average of the two groups was compared before initiating treatment, after 2 weeks, and after 2 months of treatment. The degree of improvement in the hearing was evaluated using Siegel's criteria. Before propensity score matching, the age, prevalence of diabetes or hypertension, initial hearing threshold at each frequency level (0.5, 1, 2, and 4 kHz), and treatment strategies exhibited statistically significant differences between the two groups. However, in the propensity score-matched cohort, none of the measured confounding variables showed statistically significant differences between the groups. Two months after steroid treatment, the non-dialysis patient group demonstrated a significantly higher average improvement in pure tone audiometry (P = 0.017) and a greater percentage of complete response according to Siegel's criteria compared to the dialysis patient group (26.8% vs. 6.4%). This study suggests that dialysis patients exhibit significantly poorer treatment outcomes for ISSNHL compared to non-dialysis patients.
Corrosion in reinforced concrete: Diagnostics through Potential Corrosion Technique
Authors: Reginato Lucas Alexandre , Lorenzi Alexandre , de Oliveira Leonardo Covatti , Lorenzi Luciani Somensi , Filho Luiz Carlos Pinto da Silva 
Published: July 2023

Abstract
Among the processes that accelerate the loss of performance of reinforced concrete structures, considering their frequent occurrence and severity, corrosion of reinforcement can be seen as one of the most important. A worrying factor is that most buildings in the main Brazilian urban centers are between 40 and 50 years old, a time when repairs and maintenance become more routine. Therefore, the problems related to the corrosion of the reinforcements tend to accentuate in the coming years and the identification of corrosion will play an important role. Thus, this research has the purpose of analyzing the application of the diagnosis through potential corrosion techniques. For this, full-scale reinforced concrete beams were analyzed. Corrosion was stimulated by the Modified Immersion Accelerated Corrosion - CAIM method, at three levels of mass loss: 5%, 10%, and 15%. The diagnostic technique through the corrosion potential was applied, in which it was observed that there is uncertainty in the corrosion evaluation for the mass loss levels of 5 and 10%, resulting in a corrosion uncertainty interval, but at 15%, the potential technique proved to be satisfactory.
Cytisine–N-methylene-(5,7,4’-trihydroxy)- isoflavone ameliorates ischemic stroke-induced brain injury in mouse by regulating the oxidative stress and BDNF-Trkb/Akt pathway
Authors: Li yongbiao li , fan fangcheng , Liu Qingshan 
Published: July 2023

Abstract
Background
A novel compound Cytisine–N-methylene-(5,7,4’-trihydroxy)- isoflavone (LY01) found in the Sophora alopecuroides L is a neuroprotective agent. However, the effect and potential mechanism of LY01 treatment for ischemic stroke (IS) have not been fully elucidated.
Aim of the study
The aim of this study is to demonstrate whether LY01 LY01 can rescue ischemic stroke-induced brain injury and oxygen–glucose deprivation/reperfusion (OGD/R).
Results
Our results show that intragastric administration of LY01 improves ischemic stroke behaviors in mice, as demonstrated by neurological score, infarct volume, cerebral water content, rotarod test for activity. Compared with the model group, the EGb and LY01 reversed the neurological score, infarct volume, cerebral water content, rotarod test in model mice. Further analysis showed that the LY01 rescued oxidative stress in the model mice, which was reflected in the increased levels of catalase, superoxide dismutase, total antioxidant capacity and decreased levels of malondialdehyde in the serum of the model mice. Moreover, the expression of the brain-derived neurotrophic factor BDNF, p-Akt, Bax, Bcl-2, p-Trkb was restored and the expression of Bax, GFAP in the brains of the model mice was inhibited through LY01 treatment. In the polymerase chain reaction (PCR) data, after giving LY01, the expression in the brains of model mice was that, IL-10 increased and IL-1β, Bax, Bcl-2 decreased. Furthermore, our results indicated that LY01 improved cell viability, reactive oxygen species content, and mitochondrial membrane potential dissipation induced by OGD/R in primary culture of rat cortical neurons. Bax and caspase-3 activity was upregulated compared to the before after treatment with LY01.
Conclusions
Our study suggests that LY01 reversed ischemic stroke by reducing oxidative stress and activating the BDNF-TrkB/Akt pathway and exerted a neuroprotective action against OGD/R injury via attenuation, a novel approach was suggested to treat ischemic stroke.
Comparison of laparoscopic lateral lymph node dissection for rectal cancer with and without routine resection of the visceral branches of internal iliac artery
Authors:   511521199710222718 Xiao, Zhang Xubing , Gu Chaoyang , Deng Xiangbing , Meng Wenjian , Wei Mingtian , Wang Ziqiang 
Published: July 2023

Abstract

Background:The lateral-pelvic recurrence after lateral lymph node (LLN) dissection (LLND) in patients with lateral lymph node metastasis (LLNM) remained high, especially in the absence of neoadjuvant chemoradiotherapy. Incomplete resection of lymphatic tissue in the lateral compartment, given the complex anatomy and variation of the internal iliac vessels, might contribute to the local failure. This study aimed to explore the safety and feasibility of the modified LLND with routine resection of the visceral branches of internal iliac vessels (IIVs) for mid-low-lying rectal cancer.
Materials and method: Consecutive patients undergoing LLND for rectal cancer were divided into the RVR group (routine visceral branches of the IIVs resection group) and the NRVR group (without routine resection). The main outcomes were postoperative complications and the number of LLN harvested.
Results: From 2012 to 2021, a total of 75 and 57 patients were included in the RVR and NRVR group, respectively. The operative time was reduced in the RVR group (P=0.020). No significant difference was observed between the two groups for the incidence of total, major, or minor postoperative complications. Pathologically confirmed LLNM were 24 (32%) patients in the RVR group and 12 (21.1%) in the NRVR group (P=0.162). The number of LLN harvested had no significant difference between two groups (11 vs 12, P=0.329).
Conclusion: LLND with routine resection of visceral branches of IIVs is safe and feasible, which is promising to improve LLN clearance and the detection rate of LLNM without bringing additional major complications or harm to long-term urinary function.
The Impact of governance on agricultural value-added inequality nexus in Pakistan
Authors: Khan Ziaullah , Chiu Yi-Bin 
Published: July 2023

Abstract
This study empirically investigates the intricate relationship between governance (GOV), agricultural value-added (AVA), and income inequality in Pakistan from 1984 to 2018. The study employed a time series threshold regression estimates technique to investigate non-linear dynamics among the variables. The results indicate that the relationship between GOV and income inequality is not linear and dependent on the level of GOV. The empirical results show that GOV improvements reduce income inequality at lower threshold levels. However, at a higher threshold level, GOV improvements can lead to an increase in income inequality. These findings suggest that policy efforts to decrease income disparity in Pakistan should consider both the state of GOV and supplemental measures to reduce inequality successfully. The study further employed the Atkinson and Palam ratio other than the Gini coefficient for reliability. The diagnostic tests show that the model is well-specified and robust. The results further provide some crucial guidelines for reducing income inequality in Pakistan.
The SOX4/EZH2/SLC7A11 signaling axis mediates ferroptosis in calcium oxalate crystal deposition-induced kidney injury.
Authors: Yan Xinzhou , Cheng Fan , Xia Yuqi , Li Bojun , Ye Zehua , Li Lei , Yuan Tianhui , Song Baofeng , Yu Weimin , Rao Ting , Ning Jinzhuo , Lin Fangyou , Mei shuqin , Mao Zhiguo , Zhou Xiangjun , Li Wei 
Published: July 2023

Abstract
Epigenetic regulation is reported to play a significant role in the pathogenesis of various kidney diseases, including renal cell carcinoma, acute kidney injury, renal fibrosis, diabetic nephropathy, and lupus nephritis. However, the role of epigenetic regulation in calcium oxalate (CaOx) crystal deposition-induced kidney injury remains unclear. Our study demonstrated that the upregulation of enhancer of zeste homolog 2 (EZH2)-mediated ferroptosis facilitates CaOx-induced kidney injury. CaOx crystal deposition promoted ferroptosis in vivo and in vitro. Usage of liproxstatin-1 (Lip-1), a ferroptosis inhibitor, mitigated CaOx-induced kidney damage. Single-nucleus RNA-sequencing, RNA-sequencing, immunohistochemical and western blotting analyses revealed that EZH2 was upregulated in kidney stone patients, kidney stone mice, and oxalate-stimulated HK-2 cells. Experiments involving in vivo EZH2 knockout, in vitro EZH2 knockdown, and in vivo GSK-126 (an EZH2 inhibitor) treatment confirmed the protective effects of EZH2 inhibition on kidney injury and ferroptosis. Mechanistically, the results of RNA-sequencing and chromatin immunoprecipitation assays demonstrated that EZH2 regulates ferroptosis by suppressing solute carrier family 7, member 11 (SLC7A11) expression through trimethylation of histone H3 lysine 27 (H3K27me3) modification. Additionally, SOX4 regulated ferroptosis by directly modulating EZH2 expression. Thus, this study demonstrated that SOX4 facilitates ferroptosis in CaOx-induced kidney injury through EZH2/H3K27me3-mediated suppression of SLC7A11.
Hepatitis B virus gene integration affects the efficacy of systemic drug therapy after radical resection of liver cancer: A prospective cohort study
Authors: Li Zixiong , Chen Chao , Si Anfeng , Qu Wenshu , Zhang Jue , Li Huiyu , Xia Zhaojun , Luo Linhua , Zhang Yuanjing , Liu Xiufeng 
Published: July 2023

Abstract
Objective
Hepatitis B virus (HBV) gene integration is an important factor in the occurrence and development of HBV-hepatocellular carcinoma (HBV-HCC); however, its role in the clinical treatment of liver cancer is still unclear. This study aimed to investigate the effect of HBV integration on the prognosis of patients.
Method
Twenty patients with HBV-HCC were included based on strict inclusion criteria. Whole genome sequencing of HBV-HCC surgical specimens was performed to identify HBV gene integration events. After systemic drug treatment (tyrosine kinase inhibitors alone or in combination with immune checkpoint inhibitors), the therapeutic efficacy was evaluated based on RECIST 1.1 criteria. COX regression model was used to identify factors affecting progression-free survival (PFS) and overall survival (OS).
Result
HCC tissue samples from 20 HBV-HCC patients were sequenced and matched with standard sequence. HBV integration was found in 10 out of the 20 patients. The highest frequency of HBV integration occurred on chromosome 5. Survival analysis showed that HBV integration was a risk factor for HCC recurrence (hazard ratio [HR]: 3.366, P = 0.019). However, there was no significant effect of HBV integration on the PFS after first-line systemic drug treatment (P = 0.313). The overall survival of HCC patients with HBV integration was significantly shorter than their counterparts without HBV integration (HR [95% CI]: 6.335 [1.237–32.446]; P = 0.027).
Conclusion
HBV integration event was found to be a risk factor for HCC recurrence in HBV-HCC patients after radical surgery. Patients with HBV integration are potential candidates for active intervention in the early postoperative period.
Effect of Phosphodiesterase Type 5 Inhibitors in the Active Phase of Peyronie’s Disease: A Retrospective Cohort Study
Authors: Durukan Emil , Kraglund Rune , Rashid Shad , Thorkilgaard Tine , Jensen Christian , Fode Mikkel 
Published: July 2023

Abstract
Objectives
Experimental models and preliminary human trials have implied that continuous treatment with Phosphodiesterase Type 5 inhibitors (PDE5is) may be a viable treatment of Peyronie’s disease (PD) in the active phase. The purpose of this study is to assess the effect of PDE5is on penile curvature in the management of PD in the active phase.
Subjects and Methods
We performed a retrospective cohort study of patients with PD in the active phase seen between 2017 and 2021. Patient age, comorbidities, BMI, erectile function, and PD characteristics including pain, treatment, and curvatures at each visit were registered. The primary outcome was the change in penile curvature between visits in patients receiving daily PDE5i treatment compared to patients receiving no treatment.
Results
133 patients were identified, with 101 (75.9%) receiving treatment with daily PDE5is (Group 1) and 32 (24.1%) receiving no treatment (Group 2). The mean age was 58.5 (SD 10) years in group 1 and 59 (SD 13.7) years in group 2. The mean time between the onset of symptoms and the first clinical visit was 10.6 (SD 7.3) months in group 1 and 13.4 (SD 19) months in group 2. The mean change in penile curvature between the first and last observations in group 1 and group 2 was + 0.87° (CI: -1.8, 3.5) and + 5.72° (95% CI: 1.4, 10), respectively (p = 0.07). A multivariate analysis controlling for baseline curvature and time between the onset of symptoms and the first clinical visit showed no significant differences in penile curvature changes between the groups (-4.7, 95% CI: -10, 0.6) (p = 0.08).
Conclusions
Continuous PDE5i treatment appeared to have no influence on the progression of PD in the active phase. The main limitation of the study is its retrospective nature. Randomized controlled trials are needed to draw a definitive conclusion.
Inhibition of sepsis-induced pancreatic injury by leukotriene receptor antagonism via modulation of oxidative injury, and downregulation of inflammatory markers in experimental rats
Authors: Hagar Hanan H. , Alhazmi Shaima M. , Arafa Maha 
Published: July 2023

Abstract
Purpose
The purpose of this study is to investigate the effect of montelukast on lipopolysaccharide (LPS)-induced pancreatitis.
Methods
Acute pancreatitis was induced by a single dose of LPS (6 mg/kg, i.p.) while montelukast was given in two different doses (10 and 20 mg/kg/day) for three consecutive days prior to injection of LPS.
Results
Acute pancreatitis was demonstrated by significant increases in serum levels of pancreatic enzymes lipase and amylase and lactate dehydrogenase (LDH). Proinflammatory response activation was evident by elevated serum levels of nitric oxide (NO) and increased pancreatic concentrations of tumor necrosis factor- α (TNF-α), interleukin-1 (IL-1β) and intercellular adhesion molecule-1 (ICAM-1). The activity of myeloperoxidase (MPO), a neutrophil infiltration marker, has also been increased. Oxidative stress was confirmed by significant increases in the concentrations of lipid peroxides measured as thiobarbituric acid reactive substances (TBARS) and decreases in the concentrations of reduced glutathione (GSH) in the pancreatic tissues of animals treated with LPS. Histological examination confirmed the biochemical alterations. Montelukast treatment reversed all these biochemical indices and histopathological changes that were induced by LPS. Montelukast reduced the increase in serum levels of lipase, amylase, LDH, total nitrite/nitrate, TNF-α, IL-1β and ICAM-1. MPO activities and TBARS concentrations were also suppressed while GSH content was increased in pancreatic tissues.
Conclusion
These results show that montelukast may be a useful pharmacological agent in protection against LPS-induced oxidative pancreatic injury by inhibiting neutrophil infiltration, counteracting oxidative stress, and suppressing inflammatory mediators.