bluuebunny/crossref_metadata_2025_split huggingface dataset:
New human in vitro co‐culture model of keratinocytes and sensory neurons like cells releasing substance P with an evaluation of the expression ofZIKVentry receptors: A potent opportunity to test Zika virus entry and to study Zika virus' infection in neurons?
Authors: Bocciarelli Claire , Cordel Nadège , Leschiera Raphael , Talagas Matthieu , Le Gall‐Ianotto Christelle , Hu Weiguo , Marcorelles Pascale , Bellemere Gaëlle , Bredif Stéphanie , Fluhr Joachim , Misery Laurent , Lebonvallet Nicolas 
Published: July 2023

AbstractDuring the course of acute ZIKV infection, pruritus is a cardinal symptom widely documented in the literature. Its frequent association with dysesthesia and several dysautonomic manifestations, suggests a pathophysiological mechanism involving the peripheral nervous system. The aim of this study was to develop a functional human model to potentially able to be infected by ZIKV: by demonstrating the functionality on a new human model of co‐culture of keratinocyte and sensory neuron derived from induced pluripotent stem cells using a classical method of capsaicin induction and SP release, and verify the presence of ZIKV entry receptor in these cells. Depending of cellular type, receptors of the TAMs family, TIMs (TIM1, TIM3 and TIM4) and DC‐SIGN and RIG1 were present/detected. The cells incubations with capsaicin resulted in an increase of the substance P. Hence, this study demonstrated the possibility to obtain co‐cultures of human keratinocytes and human sensory neurons that release substance P in the same way than previously published in animal models which can be used as a model of neurogenic skin inflammation. The demonstration of the expression of ZIKV entry receptors in these cells allows to considerate the potent possibility that ZIKV is able to infect cells.
Heterogeneity in protocols and outcomes to study the effect of renin‐angiotensin system blockers in inflammatory bowel disease: A systematic review
Authors: Ferreira‐Duarte Mariana , Tonin Fernanda S. , Duarte‐Araújo Margarida , Fernandez‐Llimos Fernando , Morato Manuela 
Published: July 2023

AbstractBackgroundThe renin‐angiotensin system (RAS) has been associated with inflammatory bowel disease (IBD), supporting translational relevance of RAS blockers. Comparability of study design/outcomes is fundamental for data analysis/discussion.ObjectivesWe aimed at evaluating the heterogeneity among protocols and outcomes to study the effect of angiotensin‐converting enzyme inhibitors or angiotensin receptor blockers in IBD.MethodsThis study was performed and reported in accordance with the Cochrane recommendations and PRISMA (PROSPERO‐CRD42022323853). Systematic searches were performed in PubMed, Scopus and Web of Science. Studies that met the inclusion criteria were selected. Quality assessment of the studies was done with the SYRCLES's risk of bias tools for animal studies.ResultsThirty‐five pre‐clinical studies and six clinical studies were included. Chemical induction of colitis was the most used model, but variable doses of the induction agent were reported. All studies reported at least a disease activity index, a macroscopic score, or a histologic assessment, but these scores were methodologically heterogeneous and reported for different characteristics. Great heterogeneity was also found in drug interventions. Inflammatory markers assessed as outcomes were different across studies.ConclusionLack of standardization of protocols and outcomes among studies threatens the evidence on how RAS blockers influence IBD outcomes.
Information theory and headache triggers
Authors: Turner Dana P. , Caplis Emily , Bertsch Julia , Houle Timothy T. 
Published: July 2023

AbstractObjectivesThis secondary analysis evaluated the information content exhibited by various measurement strategies of commonly perceived causes, or “triggers,” of headache attacks.BackgroundWhen evaluating triggers of primary headache attacks, the variation observed in trigger candidates must be measured to compare against the covariation in headache activity. Given the numerous strategies that could be used to measure and record headache trigger variables, it is useful to consider the information contained in these measurements.MethodsUsing previously collected data from cohort and cross‐sectional studies, online data sources, and simulations, the Shannon information entropy exhibited by many common triggers was evaluated by analyzing available time‐series or theoretical distributions of headache triggers. The degree of information, reported in bits, was compared across trigger variables, measurement strategies, and settings.ResultsA wide range of information content was observed across headache triggers. Due to lack of variation, there was little information, near 0.00 bits, in triggers like red wine and air conditioning. Most headache triggers exhibited more information when measured using an ordinal scale of presence/degree (e.g., absent, mild, moderate, severe) versus a present/absent binary coding. For example, the trigger “joy” exhibited 0.03 bits when assessed using binary coding but 1.81 bits when coded using an ordinal scale. More information was observed with the use of count data (0.86 to 1.75 bits), Likert rating scales (1.50 to 2.76 bits), validated questionnaires (3.57 to 6.04 bits), weather variables (0.10 to 8.00 bits), and ambulatory monitoring devices (9.19 to 12.61 bits).ConclusionsAlthough commonly used, all binary‐coded measurements contain ≤1.00 bit of information. Low levels of information in trigger variables make associations with headache activity more difficult to detect. Assessments that balance information‐rich measurements with reasonable participant burden using efficient formats (e.g., Likert scales) are recommended to enhance the evaluation of the association with headache activity.
University students' academic grit and academic achievements predicted by subjective well‐being, coping resources, and self‐cultivation characteristics
Authors: Harpaz Gal , Vaizman Tal , Yaffe Yosi 
Published: July 2023

AbstractThe connection between grit and achievement in a variety of areas is well documented. Nevertheless, the factors that affect domain‐specific academic grit and the relationship of these factors to academic achievement still require clarification. The present study aimed to explore the contribution of three main categories of variables: subjective well‐being (SWB), coping resources (e.g., self‐efficacy and help‐seeking orientation (HSO)), and self‐cultivation characteristics (e.g., savouring art and personal growth) to academic grit and academic achievement as well as the significance of academic grit as a predictor and mediator for academic achievement. The sample comprised a total of 351 university students between the ages of 18 and 58 from Anglophonic countries (US, Canada, and UK), and Israel. Using structural equation modelling (SEM), academic grit was found to be directly associated with academic achievement among university students while SWB, coping resources, and self‐cultivation characteristics were only indirectly associated with academic achievement with the mediation of academic grit. These results have important educational implications since they reveal existing effects which should serve as a basis for the implementation of university programmes. The results indicate the importance of student well‐being, coping resources, and self‐cultivating characteristics, especially regarding personal growth to perform optimally at university studies.
Trajectory and predictors of family function in caregivers of stroke survivors: A longitudinal study of the first 6 months after stroke
Authors: Zhang Wei , Ye Mingming , Zhou Wanqiong , Gao Yitian , Zhou Lanshu 
Published: July 2023

AbstractAimsThis study aimed to investigate the trajectory and predictors of family function in caregivers of stroke survivors during the first 6 months after the first episode of stroke.DesignLongitudinal study.MethodsA total of 288 primary caregivers of patients with first‐time stroke were recruited from seven tertiary hospitals in China between July 2020 and March 2021. The following characteristics were assessed by caregivers at hospitalization (T0) and at 1 month (T1), 3 months (T2) and 6 months (T3) after the stroke: family function, general self‐efficacy, social support, coping style, caregiver burden, and sociodemographic and clinical data.ResultsFamily function scores among caregivers of stroke survivors were highest in the resolve dimension and lowest in the growth and adaptation dimensions within the first 6 months. The percentages of families with low functioning were 34.7%, 33.3%, 24.8% and 17.7% at T0, T1, T2 and T3, respectively. The generalized estimating equation model revealed that family function in caregivers increased over the first 6 months (Exp(B) = 1.415–2.689,p < .05). The following factors were identified as predictors of family functioning: caregiver's age, education, residential district, self‐efficacy, social support utilization and caregiver burden.ConclusionsFamily function of caregivers of stroke survivors gradually increased during the first 6 months after stroke. However, some families demonstrated poor functioning. Caregivers' age, education, caregiver burden, self‐efficacy and social support utilization could predict family function over time.ImpactEmpirical data on family function in families of stroke survivors are important for developing psychosocial interventions that can help families adapt to stroke. This study found that families of stroke survivors were likely to be dysfunctional in the first 6 months after stroke, particularly in family growth and adaptation. Therefore, reducing caregiver burden and promoting self‐efficacy and social support utilization can help restore family functioning early after stroke.Patient or Public ContributionStroke caregivers from seven hospitals in China were involved in this study and had the right to be informed of the main findings. A few patients were informed of the research results, who contributed to the dissemination.
20 years of interactive tasks in large‐scale assessments: Process data as a way towards sustainable change?
Authors: Stadler Matthias , Brandl Laura , Greiff Samuel 
Published: July 2023

AbstractBackgroundOver the last 20 years, educational large‐scale assessments have undergone dramatic changes moving away from simple paper‐pencil assessments to innovative, technology‐based assessments. This comprehensive switch has led to some rather technical improvements such as identifying early guessing or improving standardization.ObjectivesAt the same time, process data on student interaction with items has been shown to carry value for obtaining, reporting, and interpreting additional results on student skills in international comparisons. In fact, on the basis of innovative simulated assessment environments, news about student rankings, under‐ and overperforming countries, and novel ideas on how to improve educational systems are prominently featured in the media. At the same time, few of these efforts have been used in a sustainable way to create new knowledge (i.e., on a scientific level), to improve learning and instruction (i.e., on a practical level), and to provide actionable advice to political stakeholders (i.e., on a policy level).MethodsThis paper will adopt a meta‐perspective and discuss recent and current developments with a focus on these three perspectives. There will be a particular emphasis on new assessment environments that have been recently employed in large‐scale assessments.Results and ConclusionsMost findings remain very task specific. We propose a necessary steps that need to be taken in order to yield sustainable change from analysing process data on all three levels.ImplicationsNew technologies might be capable of contributing to the research‐policy‐practitioner gap when it comes to utilizing the results from large‐scale assessments to increase the quality of education around the globe but this will require a more systematic approach towards researching them.
Environmentally independent selection for hybrids between divergent freshwater stickleback lineages in semi-natural ponds
Authors: Hudson Cameron Marshall , Cuenca Cambronero Maria , Moosmann Marvin , Narwani Anita , Spaak Piet , Seehausen Ole , Matthews Blake 
Published: July 2023

Abstract
Hybridization following secondary contact of genetically divergent populations can influence the range expansion of invasive species, though specific outcomes depend on the environmental dependence of hybrid fitness. Here, using two genetically and ecologically divergent threespine stickleback lineages that differ in their history of freshwater colonization, we estimate fitness variation of parental lineages and hybrids in semi-natural freshwater ponds with contrasting histories of nutrient loading. In our experiment, we found that fish from the older freshwater lineage (Lake Geneva) and hybrids outperformed fish from the younger freshwater lineage (Lake Constance) in terms of both growth and survival, regardless of the environmental context of our ponds. Across all ponds, hybrids exhibited the highest survival. Although wild-caught adult populations differed in their functional and defence morphology, it is unclear which of these traits underlie the fitness differences observed among juveniles in our experiment. Overall, our work suggests that when hybrid fitness is insensitive to environmental conditions, as observed here, introgression may promote population expansion into unoccupied habitats and accelerate invasion success.
Abstract
We experimentally tested the performance of two divergent stickleback lineages and their hybrids under contrasting environmental conditions in a common garden setting. Hybrid fitness appeared insensitive to environmental conditions, and this could indicate that naturally occurring introgression between the populations may promote population expansion.
Surgical site infection following open lobectomy in patients with lung cancer: A prospective study
Authors: Li Shiyu , Lin Ji , Ye Lijuan , Qiao Fu , Huang Wenzhi , Peng Yalan , Huang Jin 
Published: July 2023

AbstractObjectiveTo assess the incidence and risk factors of surgical site infection after open pulmonary lobectomy and to quantify their clinical and economic burden.MethodsA prospective nested case‐control study was performed on patients with lung cancer who underwent open lobectomy in the lung cancer center of West China Hospital from January 2017 to December 2019. Demographic, clinical data and medical costs were recorded. Logistic regression was used to evaluate risk factors associated with surgical site infection. A Mann‐Whitney U test was carried out to evaluate the differences in medical costs.ResultsA total of 1395 patients were eligible, and the surgical site infection incidence was 13.47% (188/1395). Of the 188 instances of surgical site infection, 171 (90.96%) were classified as organ/space infection, 8 (4.25%) as superficial incisional infection and 9 (4.79%) as deep incisional infection. The patients with surgical site infection had significantly higher mortality (3.19% vs. 0.41%, p < 0.001), higher median medical cost (90774.95 yuan vs. 63079.38 yuan, p < 0.001), and longer postoperative length of stay (15 days vs. 9 days, p < 0.001). Multivariate logistic regression analysis indicated that age (odds ratio (OR) = 1.560, p = 0.007), respiratory failure (OR = 5.984, p = 0.0012), American Society of Anesthesiologists score (OR = 1.584, p = 0.005), operating time (OR = 1.950, p < 0.001), and operation team (OR = 1.864, p < 0.001) were independent risk factors for surgical site infection.ConclusionsThe high incidence of surgical site infection indicates that postoperative infections remain a significant clinical burden in patients who underwent open lobectomy. Identifying risk factors timely through prospective surveillance may assist clinical decisions against surgical site infection.
The role of predation risk in structuring life‐history traits of crucian carp (Carassius carassius) in a series of small boreal lakes
Authors: de Meo Ilaria , Østbye Kjartan , Kahilainen Kimmo K. , Poléo Antonio B. S. 
Published: July 2023

AbstractPredation is a major evolutionary force determining life‐history traits in prey by direct and indirect mechanisms. This study focuses on life‐history trait variation in crucian carp (Carassius carassius), a species well known for developing a deep body as an inducible morphological defence against predation risk. Here, the authors tested variation in growth and reproductive traits in 15 crucian carp populations in lakes along a predation risk gradient represented by increasingly efficient predator communities. Lakes were located in south‐eastern Norway and were sampled in summer 2018 and 2019. The authors expected crucian carp to attain higher growth rate, larger size, and later age at maturity with increasing predation risk. In the absence of predators, they expected high adult mortality, early maturity and increased reproductive effort caused by strong intraspecific competition. They found that the life‐history traits of crucian carp were clearly related to the presence of piscivores: with increasing predation risk, fish grew in body length and depth and attained larger asymptotic length and size at maturity. This growth was evident at young age, especially in productive lakes with pike, and it suggests that fish quickly outgrew the predation window by reaching a size refuge. Contrary to the authors’ predictions, populations had similar age at maturity. High‐predation lakes also presented low density of crucian carp. This suggests that fish from predator lakes may experience high levels of resource availability due to reduced intraspecific competition. Predation regulated life‐history traits in crucian carp populations, where larger size, higher longevity and size at maturity were observed in lakes with large gaped predators.
Traumatic chylothorax in urbanized free‐ranging black‐tufted marmosets (Callithrix penicillata)
Authors: Barros Rafaela Magalhães , de Macêdo Isabel Luana , de Sousa Davi Emanuel Ribeiro , Hirano Líria Queiroz Luz , Paludo Giane Regina , de Castro Márcio Botelho 
Published: July 2023

AbstractAfter fatal traumatic injuries, three urbanized free‐ranging marmosets developed a milky white or pink‐white thoracic alkaline effusion with high specific gravity, triglyceride levels, and predominance of small lymphocytes. Chylothorax is an uncommon thoracic fluid accumulation in animals and humans and has not been reported in free‐ranging non‐human primates.
Understanding the Postpartum Cesarean Pain Experience Among Individuals With Publicly Funded Insurance: A Qualitative Investigation
Authors: Badreldin Nevert , DiTosto Julia D. , Leziak Karolina , Niznik Charlotte M. , Yee Lynn M. 
Published: July 2023

IntroductionPain is the most common postpartum concern and has been associated with adverse outcomes, such as difficulty with neonatal bonding, postpartum depression, and persistent pain. Furthermore, racial and ethnic disparities in the management of postpartum pain are well described. Despite this, less is known regarding patients’ lived experiences regrading postpartum pain. The purpose of this study was to assess patient experiences related to postpartum pain management after cesarean birth.MethodsThis is a prospective qualitative study of patients’ experiences with postpartum pain management after cesarean birth at a single large tertiary care center. Individuals were eligible if they had publicly funded prenatal care, were English or Spanish speaking, and underwent a cesarean birth. Purposive sampling was used to ensure a racially and ethnically diverse cohort. Participants underwent in‐depth interviews using a semistructured interview guide at 2 time points: postpartum day 2 to 3 and 2 to 4 weeks after discharge. Interviews addressed perceptions and experiences of postpartum pain management and recovery. Data were analyzed using the constant comparative method.ResultsOf 49 participants, 40.8% identified as non‐Hispanic Black and 40.8% as Hispanic. The majority (59.2%) had experienced a cesarean birth with a prior pregnancy. Thematic analysis yielded 2 overarching domains: (1) experience of pain after cesarean birth and (2) pain management and opioid use after cesarean birth. Themes related to the experience of pain included pain as a meaningful experience, pain not aligned with expectations, and limitations caused by pain. All participants discussed limitations caused by their pain, voicing frustration with pursuing activities of daily living, caring for home and family, caring for neonate, and impact on mood. Themes related to pain management and opioid use addressed a desire for nonpharmacologic pain management, positive and negative experiences using opioids, and hesitancy and perceived judgement regarding opioid use. Several participants described experiences of judgement regarding the request for opioids and needing stronger pain medications, such as oxycodone.DiscussionUnderstanding experiences regarding postpartum cesarean pain management and recovery is essential to improving patient‐centered care. The experiences identified by this analysis highlight the need for individualized postpartum pain management, improved expectation counseling, and the expansion of multimodal pain management options.
Effectiveness of interprofessional tracheostomy teams: A systematic review
Authors: Ninan Ashly , Grubb Lisa M. , Brenner Michael J. , Pandian Vinciya 
Published: July 2023

AbstractAim(s)To systematically locate, evaluate and synthesize evidence regarding effectiveness of interprofessional tracheostomy teams in increasing speaking valve use and decreasing time to speech and decannulation, adverse events, lengths of stay (intensive care unit (ICU) and hospital) and mortality. In addition, to evaluate facilitators and barriers to implementing an interprofessional tracheostomy team in hospital settings.DesignSystematic review using Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) and Johns Hopkins Nursing Evidence‐Based Practice Model's guidance.MethodsOur clinical question: Do interprofessional tracheostomy teams increase speaking valve use and decrease time to speech and decannulation, adverse events, lengths of stay and mortality? Primary studies involving adult patients with a tracheostomy were included. Eligible studies were systematically reviewed by two reviewers and verified by another two reviewers.Data SourcesMEDLINE, CINAHL and EMBASE.ResultsFourteen studies met eligibility criteria; primarily pre‐post intervention cohort studies. Percent increase in speaking valve use ranged 14%–275%; percent reduction in median days to speech ranged 33%–73% and median days to decannulation ranged 26%–32%; percent reduction in rate of adverse events ranged 32%–88%; percent reduction in median hospital length of stay days ranged 18–40 days; no significant change in overall ICU length of stay and mortality rates. Facilitators include team education, coverage, rounds, standardization, communication, lead personnel and automation, patient tracking; barrier is financial.ConclusionPatients with tracheostomy who received care from a dedicated interprofessional team showed improvements in several clinical outcomes.Implications for Patient CareAdditional high‐quality evidence from rigorous, well‐controlled and adequately powered studies are necessary, as are implementation strategies to promote broader adoption of interprofessional tracheostomy team strategies. Interprofessional tracheostomy teams are associated with improved safety and quality of care.ImpactEvidence from review provides rationale for broader implementation of interprofessional tracheostomy teams.Reporting MethodPRISMA and Synthesis Without Meta‐analysis (SWiM).Patient/Public ContributionNone.