bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unraveling the Relationship Between Vitamin D and Noncommunicable Diseases: A Systemic Review and Meta‐Analysis
Authors: Dumbre Dipali , Upendra Sheela , Zacharias Betsy Sara 
Published: January 2025

ABSTRACTBackgroundSubclinical vitamin D insufficiency is frequent in both developing and developed countries. Even after rickets was eliminated in the 1930s by fortifying milk, up to 1 billion people worldwide suffer from subclinical vitamin D deficiency (VDD). Numerous noncommunicable diseases (NCDs), including depression, autoimmune illnesses, diabetes, osteoporosis, and cardiovascular disease, are linked to this deficiency.MethodologyThe Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) protocol was applied when conducting a systematic review. Relevant studies published between 2010 and 2023 were found by searching databases such as Web of Science, Scopus, and PubMed. To find correlations between deficiency of vitamin D and NCDs, data was extracted from the studies and analyzed using the Mixed Method Appraisal Tools (MMAT). In meta‐analysis data combined from multiple observational Unraveling the Relationship Between Vitamin D and Noncommunicable Diseases—A Systemic Review and Meta‐Analysis studies to evaluate the relationship between vitamin D insufficiency and health outcomes. Statistical techniques, such as calculating effect sizes and constructing confidence ranges, are employed to determine combined outcomes and investigate possible causal connections.ResultsFourteen studies—including cross‐sectional studies, prospective cohorts, randomized controlled trials, and longitudinal studies—met the inclusion criteria. Significant correlations among deficiency of vitamin D and a number of NCDs, including anemia, diabetes, hypertension, rheumatoid arthritis (RA), mental health issues, and autoimmune hypothyroidism, were found in the review. The results highlight the prevalence of deficiency of vitamin D worldwide and its detrimental impact on health. In order to lower the risk of numerous NCDs, this review emphasizes the need for greater awareness and possible interventions to maintain appropriate vitamin D levels. A meta‐analysis was conducted to investigate the potential causal connections between vitamin D insufficiency and different health disorders. It elucidates the connections between deficient levels of vitamin D and conditions such as mental health disorders, anemia, diabetes, hypertension, and autoimmune diseases. The study prioritizes the examination of temporal correlations, biological plausibility, and the removal of confounding factors to provide support for these associations. While the text acknowledges that experimental data, such as randomized controlled trials, would enhance the argument for causation, it mostly depends on observational studies.
The disease burden of earlier and late‐onset rheumatoid arthritis on depression and related geriatric syndromes
Authors: Keskin Demircan Sultan , Kahveci Abdulvahap 
Published: January 2025

AbstractPurposeThis study aims to compare the prevalence of depression and related geriatric syndromes in earlier‐onset rheumatoid arthritis (EORA) patients, who have experienced prolonged inflammation and medication use, with those with late‐onset rheumatoid arthritis (LORA) patients, who often present with an acute and severe course.MethodsIn this multidisciplinary study, patients with EORA and LORA aged 60 and over who were referred to a tertiary rheumatology clinic underwent a geronto‐rheumatologic evaluation. Muscle mass and handgrip strength, cognitive function, nutritional status, Fried frailty index, fall history, gait speed, depression according to Geriatric Depression Scale and Insomnia Severity Index were recorded. The disease characteristics and geriatric syndromes were compared in the two groups. The regression analysis was used to evaluate the association between depression and related variables.ResultsThe mean age of the 129 patients (F:M ratio = 4.15; comprising 64 EORA and 65 LORA) was 67.42 ± 5.18 years. The prevalence of depression, undernutrition, and frailty was observed in 36.4% (47; 129), 41.08% (53; 129), and 47.3% (61; 129), respectively. Patients with EORA presented with a significantly higher prevalence of female gender (87.7% vs. 73.4%, P = 0.033), depression (47.7% vs. 25.0%, P = 0.006), low gait speed (50.0% vs. 32.8%, P = 0.036) and polypharmacy (83.1% vs. 64.1% vs. P = 0.012) compared to patients with LORA. In the regression analysis, insomnia and undernutrition were significantly related to depression (OR: 3.29; 95%Cl: 1.41–7.69, P = 0.006, and OR: 3.03; 95% Cl: 1.33–7.03, P = 0.010, respectively).ConclusionDepression is more prevalent, particularly in patients with EORA, and is associated with malnutrition and insomnia in patients with RA. Thus, geronto‐rheumatologic evaluation should be taken into account in RA management.
The fettered and the flea: a new poem by Edmund Waller☆
Authors: Gillespie Stuart 
Published: January 2025

AbstractThis contribution explores for the first time a 22‐line poem in a British Library manuscript, ‘To a young lady that kept a flea chay'nd in a box’, which can be convincingly ascribed to Edmund Waller. Its most famous relative is Donne's ‘The Flea’, but its ancestry differs. Moreover Waller's is addressed, as a playful compliment, to a child, not a lover. Several traditions combine in it: that deriving from the pseudo‐Ovidian Pulex; that of ‘multum in parvo’ in poetry of and beyond the English Renaissance; the French verse of the contemporary précieuses. Its close relationship to Waller's ‘To a very young Lady’/‘To my young Lady Lucy Sidney’ is examined. A coda places into the same tradition a ‘flea poem’ of the later seventeenth century by Joshua Barnes.
Phenotypic and genotypic landscape of antibiotic resistance through One Health approach in Sri Lanka: A systematic review
Authors: Nisansala Thilini , Gunasekara Yasodhara Deepachandi , Piyarathne Nadisha Sewwandi 
Published: January 2025

AbstractObjectivesAntibiotic resistance (ABR) constitutes a significant burden to economies in developing countries. In the ‘One‐Health’ concept, ABR in human, animals, and environment is interconnected. The aim of this study was to critically appraise literature on ABR in all three domains in One Health, within the Sri Lankan geographical context.MethodsThe protocol was registered with PROSPERO and followed PRISMA 2020 guidelines. A comprehensive electronic literature search was conducted in PubMed, Scopus, Web of Science databases and grey literature via Google Scholar. Out of 298 abstracts, 37 articles were selected following screening. A risk of bias assessment was conducted using Joanna Briggs Institute tools. Following blinded data extraction, descriptive data analysis and narrative synthesis were performed.ResultsThis review included studies published between 2016‐2023. Of the included studies, 17 (45.9%) reported data on samples obtained from humans, 9 (24.3%) from animals, and 6 (16.2%) from environmental sources, two studies (5.4%) from humans and animals, one study on animal and environment; whereas two studies including all three domains. ABR of 32 different bacteria (Gram negative⸺17, Gram positive⸺14) was retrieved; E. coli was the most frequently studied bacteria followed by MRSA and ESBL. For E. coli, a median resistance over 50% was reported for sulfamethoxazole (88.8%), trimethoprim (79.1%), ampicillin (60%) and tetracycline (50.3%) with the highest resistance for erythromycin (98%). Of a total of 21 antibiotic‐resistance genes in E. coli, the highest genotypic resistance was for tet‐A (48.5%).ConclusionsA comprehensive description of ABR for a total of 32 bacteria, 62 antibiotics and 46 ABR genes is presented. This review discusses the contemporary ABR landscape in Sri Lanka through the One Health lens, highlighting key methodological and empirical research gaps.
Prevalence and incidence of zoonotic diseases in South Asia: a systematic review protocol
Authors: Khatoon Sajda , Mahapatra Biswajit , Thubru Edakashwa , Bhattacharya Paramita , Mukherjee Nirmalya , Bhattacharya Chanchal , Kondabattula Ganesh , Bharti Omesh , Sharma Anil , John Denny 
Published: January 2025

Objective:
This review aims to estimate the prevalence and incidence of zoonotic diseases from studies of populations from South Asia (Afghanistan, Bangladesh, Bhutan, India, Maldives, Nepal, Pakistan, and Sri Lanka).

Introduction:
South Asia is of notable importance in terms of the prevalence and incidence of endemic zoonoses, as well as its role as a focal point for emerging zoonotic diseases.

Inclusion criteria:
All populations residing in the 8 South Asian countries, irrespective of age/gender, will be considered. Primary outcomes will include studies estimating the prevalence and incidence of zoonotic diseases in South Asia. Secondary outcomes will include the burden of zoonotic diseases, including emergence and re-emergence.

Methods:
Databases including MEDLINE (PubMed), Embase (Ovid), Scopus, and Web of Science, as well as government websites, reports of multilateral agencies, and gray literature will be searched. Titles/abstracts, full screening, and critical appraisal of included studies will be conducted by 2 independent reviewers with adjudication by a third author. JBI guidelines for prevalence and incidence studies will be used to extract data from included studies. Critical appraisal of included studies will be conducted using the standard JBI checklists. Where feasible, statistical meta-analysis will be conducted to report the proportional representation related to prevalence and incidence using forest plots, along with the 95% CI. Publication bias will be assessed using Egger’s test and funnel plots, if possible. Subgroup and sensitivity analysis will be conducted using standard methods. Where statistical pooling is not possible, tables and figures will be used to present the results in a narrative synthesis.

Review registration:
PROSPERO CRD42023450289
Factors influencing direct breastfeeding of preterm infants in neonatal wards and the provision of breastfeeding support: a qualitative systematic review protocol
Authors: Crump Laura , Fontaine Guillaume , Mooney Meagan , Calleja Sabine , Feeley Nancy , Semenic Sonia 
Published: January 2025

Objective:
The objective of this review will be to synthesize the qualitative evidence on factors that influence direct breastfeeding of preterm infants in neonatal wards and the provision of breastfeeding support.

Introduction:
Breastmilk is critical for the health of preterm neonates, and infants who directly feed at the breast are more likely to receive breastmilk exclusively for longer periods. Direct breastfeeding is associated with improved maternal coping and development of maternal identity. Preterm infants are significantly less likely to breastfeed than their term counterparts. An understanding of barriers and facilitators of direct breastfeeding and breastfeeding support in neonatal wards is lacking.

Inclusion criteria:
The proposed qualitative systematic review will include studies using qualitative methods and mixed methods, exploring the perceptions of breastfeeding parents, neonatal health care staff, and/or support people about the barriers and facilitators to direct breastfeeding (ie, suckling breastmilk directly from the parent’s breast) among preterm infants (infants born at less than 37 weeks’ gestation) admitted to a neonatal ward. Articles written in English or French will be considered.

Methods:
MEDLINE (Ovid), CINAHL (EBSCOhost), Embase (Ovid), PsycINFO (Ovid), Scopus, and the Cochrane Library will be searched, with no time restrictions applied. Two independent reviewers will screen and extract data using Covidence, and a tool developed for this purpose. The findings will be coded using NVivo 15 and pooled using the meta-aggregation approach. The findings will then be mapped to specific domains of the Theoretical Domains Framework using an iteratively developed coding manual. Studies will be appraised using the JBI critical appraisal tool for qualitative research, and confidence in the overall findings will be assessed using the ConQual approach.
The effectiveness of unimodality organ preservation surgical vs organ preservation radiotherapy for early hypopharyngeal cancer: a systematic review protocol
Authors: Gunasekera Delu , Goel Sahil , Kao Stephen , Krishnan Suren , Hodge John Charles , Foreman Andrew , Stone Jennifer 
Published: January 2025

Objective:
Our aim is to determine the comparative effectiveness of unimodality organ preservation surgery versus radiotherapy on oncological and functional outcomes in patients with early hypopharyngeal cancer.

Introduction:
Early hypopharyngeal cancer is difficult to detect and therefore rarely diagnosed, as patients are often asymptomatic. Radiotherapy is considered the main treatment, although this modality has been compared to the previously used open surgical approach, which may not reflect current surgical options. This is reflected in the available literature, with a paucity of data on management guidelines. Minimally invasive surgery is providing better access to the hypopharynx, such as CO2 laser microsurgery and transoral robotic surgery. These novel surgical procedures may pave the way for revised guidelines to managing hypopharyngeal cancer.

Inclusion criteria:
We will include randomized controlled trials and quasi- (or pseudo-randomized) experimental studies that investigate organ preservation surgery and radiotherapy treatments for early hypopharyngeal cancer in adults with primary disease. Primary outcomes include disease-free survival of 2 years or up to 5-year overall survival. Secondary outcomes are functional, including swallowing, phonation, and complications associated with treatment, such as post-procedural hemorrhage; return to theater or return to operating room; tracheostomizing patients; post-radiation mucositis; dysphagia/odynophagia; and xerostomia.

Methods:
The review will follow the JBI methodology for systematic reviews of effectiveness. Four databases will be searched, namely, PubMed, Embase (Ovid), CINAHL (EBSCOhost), and the Cochrane Library. Two independent reviewers will screen studies and assess methodological quality using the JBI critical appraisal tools. Individual study estimates will be pooled in a meta-analysis and presented in forest plots.

Systematic review registration number:
PROSPERO CRD42023400206.
Effectiveness of interventions to prevent or treat prolonged grief symptoms among families of patients who die in Intensive Care Units: a systematic review protocol
Authors: Rosinhas Ana , Gomes Aramid , Silva Rosa , Ramos Lino , Alves Elisabete , Sampaio Francisco 
Published: January 2025

Objective:
The objective of this review is to evaluate the effectiveness of interventions to prevent or treat prolonged grief symptoms among families of patients who die in intensive care units (ICU).

Introduction:
Up to 52% of families of patients who die in ICU may be at risk of experiencing prolonged grief symptoms.

Inclusion criteria:
Studies of adult family members (≥18 years) of adult ICU patients (≥18 years) who underwent a treatment withdrawal or withholding decision, and who were exposed to tailored interventions to prevent or treat prolonged grief symptoms before, during, and/or after the patient’s death will be considered for inclusion. Both randomized and non-randomized controlled trials, before and after studies, interrupted time-series, cohort, and case-control studies will be considered.

Methods:
The JBI methodology for systematic reviews of effectiveness will be followed. Databases to be searched include CINAHL, Academic Search Complete, Psychology and Behavioral Sciences Collection, Cochrane Central Register of Controlled Trials, APA PsycINFO (all via EBSCOhost), PubMed, Web of Science Core Collection, and Scopus. Two independent reviewers will perform the study selection, critical appraisal, and data extraction. Studies will be pooled in meta-analysis, if possible. Heterogeneity will be assessed using the standard χ2 and I2
tests. Statistical analyses will be performed using the random effects model. The fixed effects model will be used if fewer than 5 studies are included. The Grading of Recommendations, Assessment, Development and Evaluation (GRADE) approach will be used to grade the certainty of evidence, and a Summary of Findings will be presented.

Review registration:
PROSPERO CRD42024528308
Defining and characterizing the role of the liaison in supporting 2SLGBTQIA+ people to navigate health-service settings: a scoping review protocol
Authors: Slemon Allie , Handlovsky Ingrid , Hubert Jaymelyn , Zakher Bernadette , Mussell Jessica , Crawford Jess , Gan Dara , Schmied Sage 
Published: January 2025

Objective:
This scoping review seeks to identify what is known about the role of liaisons who support two-spirit, lesbian, gay, bisexual, trans, queer, intersex, and asexual (2SLGBTQIA+) people receiving care in health-service settings, and specifically, how the 2SLGBTQIA+ liaison role is defined and characterized.

Introduction:
To mitigate the stigma and discrimination experienced by 2SLGBTQIA+ people in health-service settings, a 2SLBGTQIA+ liaison position was initiated at a Canadian hospital. A comprehensive understanding of the 2SLGBTQIA+ liaison role is integral to the implementation of 2SLGBTQIA+ liaison positions in health-service settings globally. However, a thorough understanding of the role remains unclear.

Inclusion criteria:
This scoping review will consider literature that discusses the role of liaisons supporting 2SLGBTQIA+ individuals in health-service settings. No limitations will be placed on publication date, age, geography, liaison position title, or the professional, disciplinary, or educational background of the liaison.

Methods:
This review will follow the JBI methodology for scoping reviews. Databases to be searched will include MEDLINE (Ovid), CINAHL (EBSCOhost), APA PsycINFO (EBSCOhost), LGBTQ+ Source (EBSCOhost), Scopus, Web of Science, as well as ProQuest Dissertations and Theses for gray literature. Two independent reviewers will screen titles, abstracts, and full-text articles; discrepancies will be resolved by consensus or through a third reviewer. Data will be extracted using an extraction tool developed by the research team. Findings will be presented in tabular/diagram format along with a narrative summary to highlight key themes related to the review question.

Review registration number:
Open Science Framework: osf.io/rkx6j
Tectonic history of the Mesoproterozoic Coal Creek serpentinite, Llano Uplift, central Texas, USA
Authors: Mosher Sharon , Gillis Gretchen 
Published: January 2025

The Llano Uplift Coal Creek serpentinite is one of few exposed Grenville-age ultramafic rocks and is an important element in reconstructing the tectonic history of the Grenville orogeny in Texas, USA. During Grenville-age collisional orogenesis, the ultramafic harzburgite protolith underwent dynamothermal prograde metamorphism, which resulted in partial to complete serpentinization during emplacement, deserpentinization during subsequent regional high-temperature, medium-pressure metamorphism, and continued post-kinematic metamorphism. An unrelated late (post-Grenville) serpentinization occurred when the ultramafic rocks were exposed near or at the surface.
Disequilibrium assemblages and structural fabrics allow the pressure−temperature−time path to be estimated with peak conditions ranging between 685 °C and 810 °C and pressures of 0.8−1 GPa. Although most of the serpentinite has been replaced by lizardite, layers of incompletely replaced olivine and enstatite have metamorphic chemistries and are truncated by randomly oriented anthophyllite. Foliated metasomatic blackwall zones of tremolite, Mg chlorite, talc, and magnetite have a continuous foliation with the adjacent serpentinite.
Tectonic emplacement of the serpentinite with a northward vergence occurred early in the deformational history of the Llano Uplift. The serpentinite was structurally imbricated with an exotic ensimatic arc and most likely represents the mantle portion of an obducted ophiolite. The serpentinite and ensimatic arc underwent deformation and regional amphibolite facies metamorphism together as a package, necessitating the overriding of some southern continental block. This polyphase deformational and metamorphic history is similar to the rest of the southeastern uplift and consistent with continent-arc-continent collision. The Texas Grenville-aged tectonic history provides an unambiguous record of Mesoproterozoic orogenic events not obscured by any older or younger orogeny.
Growing old before growing rich: a scoping review on ageing-related policy interventions from the WHO Southeast Asian Region
Authors: Mohan Anu , Jaihind Jothikaran Teddy Andrews , Gudi Nachiket , A K Abhijith , Ashok Lena 
Published: January 2025

BackgroundWHO Southeast Asian Region (WHO SEARO) is home to 1.94 billion people accounting for one-fourth of the global population.ObjectiveThe primary objective of this scoping review is to describe the various policy interventions implemented in countries of the WHO SEARO to address the consequences of ageing.DesignThe Arksey and O’Malley framework for scoping review was used to explore existing policy interventions on aged care.SettingWHO SEARO.MethodsTen articles and 33 grey literature discussing the various aged care interventions adopted by WHO SEARO countries were identified through a comprehensive search performed across five databases, PubMed (NCBI), Embase (Elsevier), Web of Science (Clarivate) and Scopus (Elsevier) and Google Scholar.ResultsThe review indicates that healthcare, long-term care and rehabilitation, maintenance and welfare, and old age social security are the critical domains of existing policy intervention. The grey literature, including policies, acts, legislations, agendas and plans of action adopted by WHO SEARO countries, concludes that existing interventions are spread across the differential aspects of ageing and aged care. The notable delimitations of the given policy interventions are ambiguity regarding the monitoring of the programmes, lack of benchmark standards for evaluation of progress, inadequate attention to rural poverty and lack of decentralisation.ConclusionWHO SEARO countries can respond better to ageing by reinforcing areas such as caregiver support and allowances, public financing in older care, old age health insurance, public-private partnership in mobile and institutional caring and social security systems including old age and disability pension.