bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vitamin B1 deficiency leads to high oxidative stress and mtDNA depletion caused by SLC19A3 mutation in consanguineous family with Leigh syndrome
Authors: felhi Rahma , Sfaihi Lamia , Charif Majida , Frikha Fakher , Aoiadni Nissaf , Kamoun Thouraya , Lenaers Guy , Fakhfakh Faiza 
Published: July 2023

Abstract
Leigh syndrome (LS) and Leigh-like spectrum are the most common infantile mitochondrial disorders characterized by heterogeneous neurologic and metabolic manifestations. Pathogenic variants in SLC carriers are frequently reported in LS given their important role in transporting various solutes across the blood–brain barrier. SLC19A3 (THTR2) is one of these carriers transporting vitamin-B1 (vitB1, thiamine) into the cell. Targeted NGS of nuclear genes involved in mitochondrial diseases was performed in a patient belonging to a consanguineous Tunisian family with LS and revealed a homozygous c.1264A > G (p.T422A) variant in SLC19A3. Molecular docking revealed that the p.T422A aa change is located at a key position interacting with vitB1 and causes conformational changes compromising vitB1 import. We further disclosed decreased plasma antioxidant activities of CAT, SOD and GSH enzymes, and a 42% decrease of the mtDNA copy number in patient blood. Altogether, our results disclose that the c.1264A > G (p.T422A) variant in SLC19A3 affects vitB1 transport, induces a mtDNA depletion and reduces the expression level of oxidative stress enzymes, altogether contributing to the LS phenotype of the patient.
Soil ecosystem services of an urban park in Mexico as a basis for planning
Authors: Cotler Helena , Cram Silke , Prado Blanca , Peña Victor 
Published: July 2023

Abstract
Urban parks in the cities play a crucial role in promoting sustainability and enhancing the quality of life for their residents. In an urban ecosystem, we have to make some trade-offs between the cultural and ecological ecosystem services. The soil ecosystem services depend on specific ecological conditions, therefore information on their potential to provide fundamental services is a basic requirement when constructions are planned in green areas. Mexico City, like other cities in Latin America, has very few green areas that are constantly threatened by sealing. Based on morpho-pedological landscapes (MpL) we quantify the soil carbon sequestration (SOC) and infiltration capacity in Chapultepec park. Among the 12 MpL we found the highest content of SOC in hillslopes with mixed tree vegetation and Phaeozem and the lowest in grass-dominant plain with Technosols and Leptosols. However, the SOC retention decreased by 40-50% because of sealing surfaces. For each MpL, the value of the soil saturated hydraulic conductivity calculated from pedotransfer functions (Ksc) was markedly lower than the Ksm measured with the double ring infiltrometer. In all MpL, both Ksc and Ksm were always higher than the reported maximum rainfall intensity. In the MpLs with more sealing, the runoff reaches more than 40% of the precipitated water. Based on these results, it is recommended to implement different actions such as allowing the leaves on the soils, the de-sealing of obsolete infrastructure, as well as locating the new constructions on Technosols and Leptosols to maintain Chapultepec park as a SOC sink with infiltration potential.
Identification of risk factors and development nomogram for neonatal sepsis in Group B Streptococcus-colonized mothers: A retrospective study
Authors: WU MENGQI , DENG YANBING , WANG XINYE , HE BAOMEI , ZHANG YING , Wei Fangqiang 
Published: July 2023

Abstract
Background: Neonatal clinical sepsis is recognized as a significant health problem, This study sought to identify a predictive model of risk factors for clinical neonatal sepsis.
Methods: A retrospective review about maternal-newborn dichotomy was conducted at our hospital from October 2018 to April 2023. The neonates were divided into cases and controls according to whether neonatal sepsis occurred . Multivariate logistic regression was used to determine risk factors and construct models.
Results: 339 pairs of mothers and their newborns were included in the study and classified into cases (n=84, 24.78%) and controls(n=255, 75.22%) . Logistic regression analysis showed that maternal age ≥26 years (odds ratio [OR] =0.47, 95% confidence interval [CI] 0.23-0.96, p=0.038),umbilical cord winding([OR]=1.80,95%[CI]1.06-3.05,p=0.027), maternal gestational diabetes ([OR]=2.14, 95%[CI]1.09-4.20, p=0.027) and neonatal sex as female ([OR]=0.64,95%[CI]0.38-1.00,p=0.050), and forceps assisted delivery ([OR]=4.74, 95%[CI]1.23-18.19, p=0.023) were independent factors affecting neonatal clinical sepsis outcome. A main effects model incorporating the five significant factors was constructed to predict the occurrence of clinical sepsis in neonates with an AUC value of 0. 719 (95%CI：0653～0.786).
Conclusions: A main effects model incorporating the five significant factors was constructed to help healthcare professionals make informed decisions and improve clinical outcomes.
Parathyroid allotransplantation for severe post-surgical hypoparathyroidism: a Brazilian experience
Authors: Gadelha Daniel , Filho Wellington Alves , d'Alva Catarina Brasil , de Sandes-Freitas Tainá Veras , Junior Renan Magalhães Montenegro 
Published: July 2023

Abstract
Purpose
Parathyroid allotransplantation is an alternative therapy for refractory permanent hypoparathyroidism (PH). Herein, we present the cases of two women who developed severe PH after neck surgery for papillary thyroid cancer and underwent parathyroid allotransplantation. Despite taking high doses of calcium and calcitriol supplements, the patients experienced persistent and severe hypocalcemic symptoms.
Methods
Fresh parathyroid tissue was removed and prepared from two patients with hyperparathyroidism secondary to end-stage kidney disease, and implanted in the non-dominant forearm of the recipients. Donors and recipients were ABO-compatible, and immunological screening was performed only in Case 2 (HLA typing, Panel Reactive Antibody, and crossmatch tests). A short-term immunosuppressive regimen was adopted, which consists of three days of methylprednisolone followed by seven days of prednisone.
Results
In Case 1, oral supplementation decreased to half of the initial dose one month after transplantation and to one-fifth at the end of a 12-month follow-up period. In Case 2, intravenous calcium could be discontinued one week post-transplantation, and it was not required until six months after transplantation. Serum parathyroid hormone levels did not increase and remained mostly undetectable in both cases. In contrast, serum calcium levels increased significantly, and both patients experienced relief from hypocalcemic symptoms.
Conclusion
Parathyroid allotransplantation can be an effective and safe treatment for permanent PH, and should be considered in severe cases. Nevertheless, formal recommendations depend on additional studies and validated protocols.
Evaluating an Optimal Time to Anticoagulant Reversal in Intracerebral Hemorrhage
Authors: Peters Haley , Roebuck Leslie , Harman Emily 
Published: July 2023

Abstract
Background:
The utilization of long-term oral anticoagulation is steadily expanding due to the growing number of patients diagnosed with thromboembolic diseases, such as atrial fibrillation or venous thromboembolism. Anticoagulation use can exacerbate hematoma expansion and increase intracerebral hemorrhage (ICH) volume resulting in high mortality and severe morbidity. However, unlike the treatment of ischemic stroke, the optimal time to reversal for hemorrhagic stroke is not clearly defined in the guidelines.
Observational studies have evaluated the effect of time to reversal administration and have shown improvement on inpatient mortality and hematoma enlargement. The objective of this study was to evaluate the change in functional outcomes for intracerebral hemorrhage patients who received anticoagulant reversal within 90 minutes of presentation.
Methods:
This retrospective, observational cohort study included anticoagulated adult patients diagnosed with an intracerebral hemorrhage on a computerized tomography scan who received anticoagulant reversal at Northeast Georgia Medical Center between January 1, 2018 – September 30, 2022. Patients were excluded if diagnosed with an aneurysm, another bleed, or administered desmopressin. The primary outcome was to evaluate the change in functional outcomes for ICH patients who received anticoagulant reversal within 90 minutes of presentation. Secondary outcomes included the change in functional outcomes for ICH patients who received anticoagulation reversal within 30 or 60 minutes of presentation, time to international normalized ratio (INR) normalization if on warfarin, and to assess the incidence of thrombotic and rebleed events after reversal.
Results:
Sixty-one patients met inclusion criteria with thirty-six patients receiving reversal within 90 minutes and twenty-five receiving reversal after 90 minutes of arrival. Baseline characteristics were similar between groups. Overall, there was no change in functional outcomes for patients who received anticoagulation reversal within 90 minutes (75% vs. 52%, p=0.07); 60 minutes (71% vs. 63%, p=0.49) or 30 minutes of arrival (100% vs. 64%, p=0.3) compared to after these time points. There was a similar incidence of rebleed (3% vs. 4%) and thrombotic events (6% vs. 0%) between groups.
Conclusion:
Functional outcomes were similar for intracerebral hemorrhage patients who received anticoagulation reversal within 90 minutes compared to those who received it after 90 minutes of Emergency Department arrival.
Remote Sensing Method (TLS) in Architectural Analysis and Constructive Pathology Diagnosis
Authors: Alikhodja Nadir , Zeghlache Hamza , Bousnina Monia 
Published: July 2023

Abstract
This work is proposed as a contribution to the debate pertaining to the reverse modelling in the field of cultural heritage. Besides, the development of data capture techniques in recent years, in respect such as Terrestrial LIDAR (TLS), provides the possibility to develop new procedures for the architectural heritage analysis and diagnosis. This paper presents some of the results obtained throughout the integrated use of techniques and non-invasive for the assessment of vertical constructions from point clouds that allow obtaining relevant data. Likewise, this work consists of an investigation with different integrated methodologies for extraction purpose of the geometric information, data analysis and generation of a 3D mathematical model, reliable from a formal and cultural point of view. In fact, the technique is tested on the thousand-year-old minaret of the Agadir Mosque in the Province of Tlemcen, Algeria, one of the oldest minarets in Algeria, where the geometric differences between the vertical parts, being a priori equal, are identified and analysed; in addition, the possible deformations and lesions of the structure have alike been subject to study. In this respect, the technique can be performed and reproduced on any other vertical construction of any type whatever.
Juvenile Hormone Regulates Silk Gene Expression by m6A RNA Methylation
Authors: Liu Shuaiqi , Tian Huan , Xu Yusong , Wang Huabing 
Published: July 2023

Abstract
Juvenile hormone (JH) is an indispensable insect hormone that is critical in regulating insect development and physiology. N6-methyladenosine (m6A) is the most abundant modification of RNA that regulates RNA fate in eukaryotic organisms. However, the relationship between m6A and JH remains largely unknown. Here, we found that the application of a Juvenile hormone analog (JHA) extended the larval period of Bombyx mori and increased the weight and thickness of the cocoon. Interestingly, global transcriptional patterns revealed that m6A-related genes are specifically regulated by JHA in the posterior silk gland (PSG) that synthesizes the major component of cocoon silk. By transcriptome and m6A sequencing data conjointly, we discovered that JHA significantly regulated the m6A modification in the PSG of B. mori and many m6A-containing genes are related to nucleic acid binding, nucleus, and nucleobase-containing compound metabolism. Notably, 547 genes were significantly regulated by JHA at both the m6A modification and expression levels, especially 16 silk-associated genes, including sericin2, seroin1, BmSPI4, BmSPI5, and Ldb. Among them, 11 silk genes were significantly affected by METTL3 knockdown, validating that these silk genes are targets of m6A modification. Furthermore, we confirmed that JHA directly regulates the expression of BmSPI4 and BmSPI5 through m6A modification of CDS regions. These results demonstrate the essential role of m6A methylation regulated by JH in PSG, and elucidate a novel mechanism by which JH affects silk gland development via m6A methylation. This study uncovers that m6A modification is a critical factor mediating the effect of JH in insects.
Engineering of formate dehydrogenase for improving conversion potential of carbon dioxide to formate
Authors: Shi Hong-Ling , Yuan Shu-Wei , Xi Xiao-Qi , Xie Yu-Li , Yue Chao , Zhang Ying-Jun , Yao Lun-Guang , Xue Chuang , Tang Cun-Duo 
Published: July 2023

Abstract
Formate dehydrogenase (FDH) is a D-2-hydroxy acid dehydrogenase, which can reversibly reduce CO2 to formate and thus act as non-photosynthetic CO2 reductase. In order to increase catalytic efficiency of formate dehydrogenase for CO2 reduction, the formate dehydrogenase CbFDHM2 was used as the parent to conduct single-site saturation and iterative combinatorial mutagenesis, and two mutants V328I/F285W and V354G/F285W were obtained of which reduction activity was about two times more than the CbFDHM2 and had greater potential in CO2 reduction. The optimal temperature for V328I/F285W and V354G/F285W was 55℃, and the optimal pH was 9.0. Then the molecular basis for its improvement of biochemical characteristics were preliminarily elucidated by computer-aided methods. All of these results further established a solid foundation for molecular modification of formate dehydrogenase and CO2 reduction.
ConSQL: A Database Language for Contex-aware Conversational Cooperative Query Answering
Authors: Jamil Hasan 
Published: July 2023

Abstract
In conversational query answering systems, context plays a significant role in accurately and meaningfully carrying it forward. In many chatbots, such as in Expedia, the discussion quickly degenerates into circling back to restarting the conversation or to inviting a live agent to intervene because the bot could not grasp the context. Contexts shorten interactions by way of implied query constraints to narrow search and to not repeat them in subsequent queries. In this paper, we introduce a novel way of viewing contexts as a distance function via the concept of query relaxation. We demonstrate that a typed domain distance function is sufficient to model context in a conversation. Our approach is based on the idea of non-monotonic constraint inheritance in a context hierarchy.
Exciton Confinement in Two-Dimensional, In-Plane, Quantum Heterostructures
Authors: Jariwala Deep , Kim Gwangwoo , Huet Benjamin , Stevens Christopher , Jo Kiyoung , Tsai Jeng-Yuan , Bachu Saiphaneendra , Leger Meghan , Ma Kyung Yeol , Glavin Nicholas R. , Shin Hyeon Suk , Alem Nasim , Yan Qimin , Hendrickson Joshua , Redwing Joan 
Published: July 2023

Abstract
Two-dimensional (2D) semiconductors are promising candidates for optoelectronic application and quantum information processes due to their inherent out-of-plane 2D confinement. In addition, they offer the possibility of achieving low-dimensional in-plane exciton confinement, similar to zero-dimensional quantum dots, with intriguing optical and electronic properties via strain or composition engineering. However, realizing such laterally confined 2D monolayers and systematically controlling size-dependent optical properties remain significant challenges. Here, we report the observation of lateral confinement of excitons in epitaxially grown in-plane MoSe2 quantum dots (~15-60 nm wide) inside a continuous matrix of WSe2 monolayer film via a sequential epitaxial growth process. Various optical spectroscopy techniques reveal the size-dependent exciton confinement in the MoSe2 monolayer quantum dots with exciton blue shift (12-40 meV) at a low temperature as compared to continuous monolayer MoSe2. Finally, single-photon emission was also observed from the smallest dots at 1.6 K. Our study opens the door to compositionally engineered, tunable, in-plane quantum light sources in 2D semiconductors.
Assessing the Efficacy of a Novel Fuzzy-based Clustering Algorithm for Mobile Agent Itinerary Planning in Wireless Sensor Networks using Validity Indices
Authors: Kashyap Nidhi , Upadhyaya Shuchita , Poriye Monika , Lalar Sachin , Aggarwal Shalini 
Published: July 2023

Abstract

Wireless Sensor Networks (WSN) are composed of small sensor nodes that either transmit their sensed data to the sink node directly or transmit it to its respective cluster head, which then transmits it to the sink node. However, this consumes a lot of network bandwidth and energy from the constrained sensor nodes. To address these constraints, Mobile Agents (MA) paradigm can be used in WSNs, which may lead to better energy and bandwidth conservation. When a single mobile agent is insufficient to complete a task, multiple mobile agents can be deployed to perform in parallel and reduce network latency. The set of sensor nodes and their sequence that MAs must migrate to complete a task is called an itinerary. The planning of the itinerary is the most prominent and significant issue related to the MA-based system, including the determination of an appropriate number of MAs to be dispatched, determining the set of sensor nodes and their sequence to be visited by MAs. This paper proposes a fuzzy-based algorithm to partition wireless sensor networks into a set of sensor nodes, called domains, for enhancing the efficiency of the WSN in terms of its prolonged operation. Experimental evaluations are conducted to compare the proposed algorithm with benchmarked algorithms. The paper suggests that the proposed algorithm's integration with MA-based systems can enhance their performance and prolong the WSN's lifetime.
Studying the effects of multi-path error on smartphone positioning using GNSS data
Authors: Nasr-Azadani Samin , Alizadeh Mohamad Mahdi , Schuh Harald 
Published: July 2023

Abstract

With the continuous growth of smartphone location-based applications, enhancing the positioning accuracy of these devices has become increasingly critical. Smartphones are primarily used in urban areas, where they often receive Global Navigation Satellite Systems (GNSS) signals amidst considerable noise and face challenges such as signal blockage due to numerous obstructions. Despite this, no comprehensive analysis has been conducted thus far to evaluate the impact of multipath error on the real-time accuracy of smartphone positioning. Therefore, this study aims to examine the influence of multipath error on determining the position of smartphones by utilizing raw GNSS observations. To calculate the multipath effect rate of the GNSS code observations without the need to estimate the phase ambiguity, we employ the Code Minus Carrier Phase (CMCD) observable. This indicator is then utilized to correct code rate measurements. Given that the calculation of multipath rate using CMCD measurements relies on eliminating phase jumps, we employed a Doppler integration algorithm to address this issue. The results of code-only positioning are examined across three modes: GPS-only, multi-GNSS without multipath correction, and multi-GNSS with multipath correction. These results reveal that utilizing multi-system measurements enables the estimation of positions in a greater number of epochs. The entire measurement duration becomes kinematic, and applying multipath correction to the received signal helps reduce RMS errors to approximately 2 meters for the x component (east-west) and about 0.5 meters for the y component (north-south) along the entire path.
3D toilet-paper based carbon fiber for excellent solar assisted steam generation performance
Authors: Suo Xidong , Li Yao , Liu Peiqi , Li Yingying , Guo Cuirong , Yang Jie , Qiao Hongtao , Han Sheng , Liu Chenqi , Yin Aiping 
Published: July 2023

Abstract
As a promising technology, interfacial solar steam technology has been widely recognized as an effective way to solve the shortage of energy and water, especially in remote areas. Whole roll of toilet paper (TP) is composed of well orderly layer-by-layer paper which consisted by cellulose fiber. Here, a 3D solar steam generator which is prepared by carbonized TP with the help of high temperature carbonization and NaOH activated under inert atmosphere is firstly demonstrated with excellent fresh water production capacity. Thanks to the good ordered layered structure which consisted by porous carbon fiber, the evaporation speed of obtained evaporator is up to 3.37 kg m-2 h-1 under one sun (1000 W m-2) in laboratory, and the average value of 20.4 kg m−2 day−1 in a 20 consecutive days outdoor experiment for treatment of stimulate sea water, respectively. The demonstrated 3D evaporator for per square meter can meet the drinking water demand of more than 10 people. This work opens a promising approach for utilizing unique structure of commercialized available artificial materials and technologies to produce fresh water form seawater.
Plasmon Coupling Model Between Wide-field SPR Microscopy and Gold Nanoparticles
Authors: Al-Bataineh Qais M. , Telfah Ahmad D. , Tavares Carlos J. , Hergenröder Roland 
Published: July 2023

Abstract
The coupling behavior of the wide field surface plasmon microscopy (WF-SPRM) with single-, two-, and multiple-gold nanoparticles (AuNPs) with different AuNPs sizes is investigated using theoretical, simulation, and experimental approaches. The signal intensity of a single AuNP increases from 208 a.u. to 583 a.u. as particle size increases from 40 nm to 80 nm, which shows the signal-building mechanism of Rayleigh scattering theory. A discrete particle model of SPR is used to understand the interaction between an Au-layer and a single AuNP. The calculated intensity profile of the single AuNP from the discrete particle model is accepted with the experimental data. In addition, the superposition between 2-AuNPs surface plasmon waves is studied using the finite element method as well as experimental data from WF-SPRM. The surface plasmon waves around the two particles are generated an interference pattern. Finally, it is demonstrated that plasmonic multiple particles scattering can be represented by an effective media, which is described by Maxwell-Garnet equations.