bluuebunny/crossref_metadata_2025_split huggingface dataset:
Do the Short-Term Water Diversion from Yangtze River Increase Phosphorus Bioavailability in the Water-Receiving Area?
Authors: Tian Fuwei , Dai Jiangyu , Xu Jiayi , Wu Xiufeng , Wu Shiqiang , Zhang Yu , Wang Fangfang , Gao Ang 
Published: February 2023

AbstractWater diversion projects have an important role in coping with water shortage and improving water quality, but they also have an impact on the ecological environment of lakes that cannot be ignored. As an important biogenic element for evaluating the primary productivity and eutrophication of lake water bodies, the influence of phosphorus by water diversion activities and its impact on the production and elimination of phytoplankton is lacking attention. In this study, we analyzed the phosphorus composition and bioavailability of the water channel and the Gonghu Bay of Lake Taihu under the influence of seasonal water diversion, revealed the spatio-temporal distribution patterns of phytoplankton communities in the water receiving river and lake, and analyzed the contribution of phosphorus to the variations of phytoplankton communities and their quantitative coupling relationships. The results showed that short-term water diversion in autumn and winter did not significantly increase the concentrations of particulate phosphorus in the receiving waters, but there was a risk of increasing the concentration of dissolved reactive phosphorus and dissolved organic phosphorus. The difference in total phosphorus concentrations between the diversion and non-diversion periods in Gonghu Bay was an important environmental factor influencing the phytoplankton community, and the bioavailable phosphorus could better fit the logarithm of algal cell density in all seasons, which was significantly and positively correlated with the phytoplankton cell densities. This study implies that the control of bioavailable phosphorus in the water channel can reduce the ecological risks of the water diversion project on the cyanobacterial blooms to some extent.
Ecological Evaluation of Waterways Based on Modified Neural Networks
Authors: Wu Teng , Qin Jie , Guo Runzhuo 
Published: February 2023

AbstractThe ecological condition of waterways has attracted increasing public attention in recent years, and the evaluation of the ecological status of waterways is of practical and scientific significance. To carry out an objective and credential evaluation of the ecological condition of waterways, this study compares the performance of two artificial neural networks (ANN) models, including the traditional Back Propagation (BP)-ANN model and the Particle Swarm Optimization (PSO)-BP-ANN model. The traditional BP-ANN model is characterized by a local search strategy and usually converges to local minima. This study combined the PSO algorithm with the BP-ANN model to improve the performance of the latter. An evaluation indicator system was established first based on the main features of waterway ecology, which includes 13 indicators in four aspects including the transportation function, the ecological function, the landscape function, and the economic function. A waterway ecology dataset was then established based on major waterways in China. The results show that the prediction accuracy of the BP-ANN is around 0.6 and unstable due to its local searching strategy. In contrast, the coefficient of determination of the PSO-BP-ANN model reaches 0.98, indicating the high prediction accuracy of the model. On this basis, this study further analyzed the relative importance of the four functions using the PSO-BP-ANN model. Results showed that the evaluation grades can be significantly improved by advancing the landscape function and the transportation function, and the improvement of these two scores can greatly reduce the probability of the lowest rating. The highest rating requires all four functions to be greater than certain threshold values.
Environmental Impact Assessment of Watershed Plan Under the “Three Lines and One List” Environmental Governance
Authors: Cheng Runhe , Cheng Jinxiang 
Published: February 2023

AbstractRapid and large-scale watershed development activities have imposed tremendous challenges to the sustainable development while driving economic prosperity in the areas along the watershed in China. Improving effectiveness of environmental impact assessment (EIA) of watershed planning has become a top priority for river ecological civilization. In this regard, the “three lines and one list” (TLOL) environmental governance, was proposed in the latest Chinese environmental management policy, consisting of an ecological conservation red line, an environmental quality bottom line and a resource utilization upper limit line and an environmental permit list are to be taken into account when assessing the potential effects of a watershed development plan. In this paper, an indicator system was established based on the TLOL requirements, and the rapid impact assessment matrix (RIAM) was adopt to asses watershed development alternatives. In an application of this methodology, the Jinjiang watershed development planning in Fujian province was taken as a case study to recommend an optimal alternative. Six alternatives were assessed by conducting a comprehensive comparison. The results showed that, the Alternative 2 is preferred because it has relative advantages in terms of allocating water resource in a reasonable way, safeguarding the ecological water use at downstream, controlling the small scaled hydropower generations. This research shows that the EIA of watershed planning on the basis of the TLOL governance policy is an effective way of integrating environmental management and river ecological civilization requirements into watershed development planning. It proposes not only a universal process for assessing watershed development alternatives, but also a feasible method of maximize the trade-off between water conservancy and hydropower, and other watershed development activities and river ecological protection.
Knowledge About Sediment Transport Obtained Through Multiple Operations at Ports in Japan
Authors: Kachi Tomohiko , Itui Minoru , Naruke Tatsunori , Sugiura Yukihiko 
Published: February 2023

AbstractAt a port located at the estuary in Japan, 800,000 m3/year of sediment is accumulated annually in navigation channel and basin. In order to consider effective countermeasures, it is necessary to elucidate sediment dynamics due to waves and tidal currents of the target port. Therefore, we are conducting a field observation of sediment transport and deposition. In addition, we have developed a numerical simulation model based on the results of the field survey for evaluated the countermeasure against the port sedimentation. We introduce the knowledge about sediment transport obtained through multiple operations.
3HDM with ∆(27) symmetry and its phenomenological consequences
Authors: Kalinowski J. , Kotlarski W. , Rebelo M. N. , de Medeiros Varzielas I. 
Published: February 2023

Abstract
We perform a comprehensive analysis of a version of the 3-Higgs doublet model whose scalar potential is invariant under a global ∆(27) discrete symmetry and where the three scalar doublets are chosen to transform as a triplet under this discrete group. For each of the known tree-level minima we study the mass spectra and use the oblique parameters STU as well as perturbative unitarity to constrain the parameter space of the model. We then discuss phenomenological consequences of some leading order flavour mixing quark Yukawa couplings by considering the flavour violation process b → sγ.We show that perturbative unitarity significantly constrains parameters of the model while, conversely, the beyond the Standard Model contributions to the b → sγ decay are automatically tamed by the symmetry.
A large muon EDM from dark matter
Authors: Khaw Kim Siang , Nakai Yuichiro , Sato Ryosuke , Shigekami Yoshihiro , Zhang Zhihao 
Published: February 2023

Abstract
We explore a model of dark matter (DM) that can explain the reported discrepancy in the muon anomalous magnetic moment and predict a large electric dipole moment (EDM) of the muon. The model contains a DM fermion and new scalars whose exclusive interactions with the muon radiatively generate the observed muon mass. Constraints from DM direct and indirect detection experiments as well as collider searches are safely evaded. The model parameter space that gives the observed DM abundance and explains the muon g – 2 anomaly leads to the muon EDM of dμ ≃ (4-5) × 10−22e cm that can be probed by the projected PSI muEDM experiment. Another viable parameter space even achieves $$ {d}_{\mu }=\mathcal{O}\left({10}^{-21}\right) $$

d
μ

=
O

10

−
21

e cm reachable by the ongoing Fermilab Muon g − 2 experiment and the future J-PARC Muon g − 2/EDM experiment.
Weak decays of antitriplet charmed baryons from the perspective of flavor symmetry
Authors: Zhong Huiling , Xu Fanrong , Wen Qiaoyi , Gu Yu 
Published: February 2023

Abstract
In this work, we carry out a global fit for the two-body weak decays of antitriplet charmed baryons in both SU(3) respected and broken scenarios incorporating all the available data up to date. In the SU(3) irreducible representation approach (IRA), more amplitudes for irreducible representation terms are taken into account and the ranges for their coefficients in each scenarios are predicted. By a comparison among various fitting schemes in this work, experimental data prefer the SU(3) symmetry breaking scenario. Observables of interest, branching fractions and decay asymmetries of all the Cabibbo-favored (CF), singly Cabibbo-suppressed (SCS) and doubly Cabibbo-suppressed (DCS) channels are calculated in the chosen fitting scheme. Most of our predictions are consistent well with experimental data. We further propose more ways to explore the SU(3) symmetry in charmed baryon decays: (i) A clear measurement of branching fraction on CF mode $$ {\Xi}_c^0\to {\Xi}^0{\pi}^0 $$

Ξ
c
0

→

Ξ
0

π
0

as a large difference exists between SU(3) respected and broken scenarios. (ii) The decay asymmetries of the five yet-to-be measured CF decay modes, $$ {\Xi}_c^0\to {\Lambda}^0{K}_S $$

Ξ
c
0

→

Λ
0

K
S

, Σ0KS, Ξ0π0, Ξ0η, Ξ0η′, for their opposite signs in the two different cases. (iii) The future measurement on branching fraction ratios indicated from eq. (2.10) and presented on table 7. An improved measurement for $$ \alpha \left({\Lambda}_c^{+}\to p{K}_S\right) $$
α

Λ
c
+

→
p

K
S

is called for since predictions from both fittings, including the one in current work and earlier works, and the pole model calculation prefer an opposite sign from previous experimental value. Given branching fractions of most of the CF modes and part of the SCS modes being measured, predictions for the remaining channels, including the DCS modes as well as more decay asymmetries, are anticipated to be checked by the upcoming experiments in BESIII, Belle/Belle-II and LHCb.
Catoids and modal convolution algebras
Authors: Fahrenberg Uli , Johansen Christian , Struth Georg , Ziemiański Krzysztof 
Published: February 2023

AbstractWe show how modal quantales arise as convolution algebras $$Q^X$$

Q
X

of functions from catoids X, multisemigroups equipped with source and target maps, into modal quantales value or weight quantales Q. In the tradition of boolean algebras with operators we study modal correspondences between algebraic laws in X, Q and $$Q^X$$

Q
X

. The catoids introduced generalise Schweizer and Sklar’s function systems and single-set categories to structures isomorphic to algebras of ternary relations, as they are used for boolean algebras with operators and substructural logics. Our correspondence results support a generic construction of weighted modal quantales from catoids. This construction is illustrated by many examples. We also relate our results to reasoning with stochastic matrices or probabilistic predicate transformers.
Mono-ADP-ribosylation by PARP10 inhibits Chikungunya virus nsP2 proteolytic activity and viral replication
Authors: Krieg Sarah , Pott Fabian , Potthoff Laura , Verheirstraeten Maud , Bütepage Mareike , Golzmann Alexandra , Lippok Barbara , Goffinet Christine , Lüscher Bernhard , Korn Patricia 
Published: February 2023

AbstractReplication of viruses requires interaction with host cell factors and repression of innate immunity. Recent findings suggest that a subset of intracellular mono-ADP-ribosylating PARPs, which are induced by type I interferons, possess antiviral activity. Moreover, certain RNA viruses, including Chikungunya virus (CHIKV), encode mono-ADP-ribosylhydrolases. Together, this suggests a role for mono-ADP-ribosylation (MARylation) in host-virus conflicts, but the relevant substrates have not been identified. We addressed which PARP restricts CHIKV replication and identified PARP10 and PARP12. For PARP10, this restriction was dependent on catalytic activity. Replication requires processing of the non-structural polyprotein nsP1-4 by the protease located in nsP2 and the assembly of the four individual nsP1-nsP4 into a functional replication complex. PARP10 and PARP12 inhibited the production of nsP3, indicating a defect in polyprotein processing. The nsP3 protein encodes a macrodomain with de-MARylation activity, which is essential for replication. In support for MARylation affecting polyprotein processing, de-MARylation defective CHIKV replicons revealed reduced production of nsP2 and nsP3. We hypothesized that MARylation regulates the proteolytic function of nsP2. Indeed, we found that nsP2 is MARylated by PARP10 and, as a consequence, its proteolytic activity was inhibited. NsP3-dependent de-MARylation reactivated the protease. Hence, we propose that PARP10-mediated MARylation prevents polyprotein processing and consequently virus replication. Together, our findings provide a mechanistic explanation for the role of the viral MAR hydrolase in CHIKV replication.
Gasdermin D membrane pores orchestrate IL-1α secretion from necrotic macrophages after NFS-rich silica exposure
Authors: Leinardi Riccardo , Pochet Amandine , Uwambayinema Francine , Yakoub Yousof , Quesniaux Valérie , Ryffel Bernhard , Broz Petr , Pavan Cristina , Huaux François 
Published: February 2023

AbstractIL-1α is an intracellular danger signal (DAMP) released by macrophages contributing to the development of silica-induced lung inflammation. The exact molecular mechanism orchestrating IL-1α extracellular release from particle-exposed macrophages is still unclear. To delineate this process, murine J774 and bone-marrow derived macrophages were exposed to increasing concentrations (1–40 cm2/ml) of a set of amorphous and crystalline silica particles with different surface chemical features. In particular, these characteristics include the content of nearly free silanols (NFS), a silanol population responsible for silica cytotoxicity recently identified. We first observed de novo stocks of IL-1α in macrophages after silica internalization regardless of particle physico-chemical characteristics and cell stress. IL-1α intracellular production and accumulation were observed by exposing macrophages to biologically-inert or cytotoxic crystalline and amorphous silicas. In contrast, only NFS-rich reactive silica particles triggered IL-1α release into the extracellular milieu from necrotic macrophages. We demonstrate that IL-1α is actively secreted through the formation of gasdermin D (GSDMD) pores in the plasma membrane and not passively released after macrophage plasma membrane lysis. Our findings indicate that the GSDMD pore-dependent secretion of IL-1α stock from macrophages solely depends on cytotoxicity induced by NFS-rich silica. This new regulated process represents a key first event in the mechanism of silica toxicity, suitable to refine the existing adverse outcome pathway (AOP) for predicting the inflammatory activity of silicas.
Asymptotics Near Extinction for Nonlinear Fast Diffusion on a Bounded Domain
Authors: Choi Beomjun , McCann Robert J. , Seis Christian 
Published: February 2023

AbstractOn a smooth bounded Euclidean domain, Sobolev-subcritical fast diffusion with vanishing boundary trace is known to lead to finite-time extinction, with a vanishing profile selected by the initial datum. In rescaled variables, we quantify the rate of convergence to this profile uniformly in relative error, showing the rate is either exponentially fast (with a rate constant predicted by the spectral gap), or algebraically slow (which is only possible in the presence of non-integrable zero modes). In the first case, the nonlinear dynamics are well-approximated by exponentially decaying eigenmodes up to at least twice the gap; this refines and confirms a 1980 conjecture of Berryman and Holland. We also improve on a result of Bonforte and Figalli by providing a new and simpler approach which is able to accommodate the presence of zero modes, such as those that occur when the vanishing profile fails to be isolated (and possibly belongs to a continuum of such profiles).
Reliable assessment of carbon black nanomaterial of a variety of cell culture media for in vitro toxicity assays by asymmetrical flow field-flow fractionation
Authors: Boughbina-Portolés Aaron , Sanjuan-Navarro Lorenzo , Hakobyan Lusine , Gómez-Ferrer Marta , Moliner-Martínez Yolanda , Sepúlveda Pilar , Campíns-Falcó Pilar 
Published: February 2023

AbstractCarbon black nanomaterial (CB-NM), as an industrial product with a large number of applications, poses a high risk of exposure, and its impact on health needs to be assessed. The most common testing platform for engineered (E)NMs is in vitro toxicity assessment, which requires prior ENM dispersion, stabilization, and characterization in cell culture media. Here, asymmetric flow field-flow fractionation (AF4) coupled to UV–Vis and dynamic light scattering (DLS) detectors in series was used for the study of CB dispersions in cell culture media, optimizing instrumental variables and working conditions. It was possible to disperse CB in a non-ionic surfactant aqueous solution due to the steric effect provided by surfactant molecules attached on the CB surface which prevented agglomeration. The protection provided by the surfactant or by culture media alone was insufficient to ensure good dispersion stability needed for carrying out in vitro toxicity studies. On the other hand, cell culture media in combination with the surfactant improved dispersion stability considerably, enabling the generation of shorter particles and a more favourable zeta potential magnitude, leading to greater stability due to electrostatic repulsion. It was demonstrated that the presence of amino acids in the culture media improved the monodisperse nature and stability of the CB dispersions, and resulted in a turn towards more negative zeta potential values when the pH was above the amino acid isoelectric point (IEP). Culture media used in real cell culture scenarios were also tested, and in vitro toxicity assays were developed optimizing the compatible amount of surfactant.
Graphical abstract
Effectiveness and tolerability of camrelizumab combined with molecular targeted therapy for patients with unresectable or advanced HCC
Authors: Li Ting , Guo Jiang , Liu Yushen , Du Zhaoqing , Guo Zhaoyang , Fan Yangwei , Cheng Long , Zhang Yue , Gao Xu , Zhao Yunyu , He Xinyuan , Wu Wenhua , Gao Ning , Wu Yinying , Li Jie , Zhang Yu , Kang Wen , Cai Zhifang , Wang Wenjun , Li Xiaopeng , Zan Ying , Nguyen Mindie H. , Ji Fanpu 
Published: February 2023

AbstractThere is a lack of effective programmed cell death protein 1 (PD-1)‐targeted immunotherapy with good tolerability in patients with advanced hepatocellular carcinoma (HCC) and severely compromised liver function. We assessed patient outcomes after combined camrelizumab and molecular targeted therapy in a multicenter cohort study in China. The study included 99 patients with advanced HCC (58 Child-Pugh A and 41 Child-Pugh B), 84 of them received camrelizumab combined with molecular targeted therapy from January 10, 2019, to March 31, 2021. Overall survival (OS), progression-free survival (PFS), objective response rate (ORR), disease control rate (DCR), and adverse events (AEs) were assessed. The median follow-up was 12.1 months. For patients with Child-Pugh B, the OS probability at 12-months, ORR and DCR were 49.7%, 31.7% and 65.9%, respectively, and the median PFS was 5.1 months [95% confidence interval (CI) 3.0–7.1], which were comparable with Child-Pugh A patients, although median OS was shorter in Child‐Pugh B patients (20.5 vs.13.4 months, P = 0.12). In multivariate analysis, macrovascular infiltration (MVI), but not sex, age, hepatitis B virus etiology, extrahepatic metastasis, Child-Pugh B, or AFP > 400 ng/ml, was associated with 12-months OS [hazard ratio (HR) 2.970, 95% CI 1.276–6.917, P = 0.012] and ORR (HR 2.906, 95% CI 1.18–7.16, P = 0.020). Grade 3/4 immune-related AEs occurred in 26.8% of Child-Pugh B patients, including one potentially treatment-related death. In both groups, the most common AEs were immune thrombocytopenia and hepatotoxicity. Camrelizumab combined with targeted therapy showed favorable effectiveness and tolerability with manageable toxicities in Chinese HCC patients, regardless of Child-Pugh A/B liver function. MVI was associated with suboptimal immunotherapy response and poor prognosis.
Graphical abstract
Functional gait analysis reveals insufficient hindfoot compensation for varus and valgus osteoarthritis of the knee
Authors: Rühling Marlene , Kirschbaum Stephanie , Perka Carsten , Graef Frank 
Published: February 2023

Abstract
Purpose
The hindfoot is believed to compensate varus and valgus deformities of the knee by eversion and inversion movements. But these mechanisms were merely found in static radiologic measurements. The aim of this study was, therefore, to assess dynamic foot posture during gait using pressure-sensitive wireless insoles in patients with osteoarthritis of the knee and frontal knee deformities.

Methods
Patients with osteoarthritis of the knee were prospectively included in this study. Patients were clinically and radiologically (mechanical tibiofemoral angle (mTFA), hindfoot alignment view angle (HAVA), and talar tilt (TT)) exa mined. Gait line analysis was conducted using pressure-sensitive digital shoe insoles.

Results
Eighty-two patients (varus n = 52, valgus n = 30) were included in this prospective clinical study. Radiologically, the mTFA significantly correlated with the HAVA (cor = −0.72, p < 0.001) and with the TT (Pearson’s cor = 0.32, p < 0.006). Gait analysis revealed that the gait lines in varus knee osteoarthritis were lateralized, despite the hindfoot valgus. In valgus knee osteoarthritis, gait lines were medialized, although the hindfoot compensated by varization.

Conclusions
Functional dynamic gait analysis could demonstrate that the hindfoot is not able to sufficiently compensate for frontal malalignments of the knee joint, contrary to static radiologic findings. This led to a narrowing of the joint space of the ankle medially in varus and laterally in valgus knee osteoarthritis.