bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of exotic pathogens found in a large group of imported dogs following an animal welfare investigation
Authors: Wright Ian , Whitfield Vanessa , Hanaghan Runa , Upjohn Melissa , Boyden Paula 
Published: May 2023

AbstractBackgroundIncreased dog relocation can cause dissemination of pathogen and vector populations, and this is being recognised in countries across Northern Europe, including the UK. Data regarding the prevalence of exotic infections in dogs entering the UK would be beneficial to veterinarians to help assess pets entering the UK from abroad and to help calculate the risk of establishment of novel pathogens. This study reports the findings from a group of imported dogs that was seized as part of a Royal Society for the Prevention of Cruelty to Animals (RSPCA)‐led animal welfare investigation and subsequently blood tested for exotic pathogens.MethodsAs part of the RSPCA investigation, 151 dogs were removed from the site. Blood tests were performed for Babesia canis, Ehrlichia canis, Hepatozoon canis and Leishmania infantum by PCR, Brucella canis by antibody serology and Dirofilaria immitis by blood antigen. In addition to pathogen screening, a serology titre for rabies was measured for each dog. A clinical examination was performed by a veterinary surgeon, and clinical signs were recorded.ResultsOverall, 24% (32/133) of the dogs tested positive for an infection with one or more exotic pathogens. Two dogs were positive for Br. canis antibodies and had no clinical signs indicative of infection. Leishmania was identified in 10.5% (14/133) of dogs, and all but two of these were implanted with microchips of Romanian origin. H. canis was identified in 9.6% (10/104) of dogs, all of whom had a Romanian microchip. D. immitis was identified in 4.1% (5/121) of dogs, B. canis in 2.3% (3/129) of dogs and E. canis in only 1.5% (2/131) of dogs tested. Only four dogs were found to have co‐infections. No significant association was found between the pathogens detected and presenting clinical signs.LimitationsThis was a group of rescued dogs that were tested for a range of pathogens. They were not randomly selected and as such do not represent the true prevalence of these pathogens in dogs imported into the UK.ConclusionsThis study demonstrates a range of exotic pathogens entering the UK, including Br. canis, and demonstrates the importance of screening imported dogs. The emphasis on early recognition of exotic pathogens in imported dogs has relied on screening based on relevant clinical signs and the country of origin. While these factors are useful, this study demonstrated no significant association between presenting clinical signs and the pathogens carried.
Sedative and cardiopulmonary effects of intranasal butorphanol with midazolam or dexmedetomidine in New Zealand white rabbits
Authors: Okur Sitkican , Yanmaz Latif Emrah , Golgeli Ayse , Senocak Mumin Gokhan , Ersoz Ugur , Orhun Omer Tarik , Gumurcinler Burak 
Published: May 2023

AbstractBackgroundThis study aimed to compare the sedative and cardiopulmonary effects of intranasal (IN) administration of dexmedetomidine–butorphanol (DB) and midazolam–butorphanol (MB) combinations in New Zealand white rabbits.MethodsEight New Zealand white rabbits were sedated by IN administration of a combination of 0.1 mg/kg dexmedetomidine and 0.4 mg/kg butorphanol (DB treatment) and 2 mg/kg midazolam and 0.4 mg/kg butorphanol (MB treatment). The electrocardiogram, pulse rate (PR), respiratory frequency (fR), arterial haemoglobin oxygen saturation (SpO2), fraction of expired carbon dioxide (EtCO2), rectal temperature (RT), noninvasive mean arterial pressure (MAP), noninvasive systolic arterial pressure (SAP) and diastolic arterial pressure (DAP) were recorded. The onset of sedation, duration of sedation and sedation score (SS) were also noted.ResultsThere were no significant differences in the EtCO2, RT, MAP, SAP and DAP measurements between treatments. The PR significantly decreased in DB compared with MB over time (p= 0.001). Compared with baseline, SpO2decreased over time in both treatments. The SS was significantly elevated over time in DB compared with MB (p= 0.002).LimitationsNo pharmacokinetic information was available for either treatment, so the findings should be interpreted cautiously.ConclusionsIN DB provides more effective sedation than MB, but cardiopulmonary impairment was observed in both treatments.
Enabling and Supporting Irregular Migration
Authors: Ambrosini Maurizio , Hajer Minke H. J. 
Published: May 2023

AbstractDespite widespread efforts to stop irregular migration, it continues; and irregular migrants remain present in societies, often finding alternative modes of inclusion. It is essential to recognise how a variety of intermediaries enable irregular migration. Between states, we can observe a complex interplay among ‘facilitating’ actors, including human smugglers, that provide services which help migrants cross borders. However, to a large extent, irregular migration is also enabled within states. Supporters act in favour of migrants and respond to their practical and social needs. Most of the help given to irregular migrants is informal, because irregular migrants most often cannot depend on help provided by public institutions. This chapter will describe the facilitation and support of border crossings, as well as the support given to irregular migrants in receiving societies.
Conclusion: Envisioning Better Governance of Irregular Migration
Authors: Ambrosini Maurizio , Hajer Minke H. J. 
Published: May 2023

AbstractIrregular migration is a multifaceted phenomenon that comprises various perspectives, policies, and actors. This concluding chapter sums up some key findings of research on such a contentious issue. It will discuss a narrative for irregular migration beyond the idea of ‘invasion’, so frequently employed by anti-immigrant actors in developed countries, and elaborate on why implementing policies that categorically exclude migrants is difficult. We argue in the chapter that the main reason for this difficulty is that irregular immigration is not only a force stemming from the outside; it is also deeply embedded in the internal dynamics of receiving societies. From this perspective, the fight against irregular migration is not a categorical exclusion; instead, it is a tacit selection which targets some cases with fierce determination while implicitly but systematically condoning others. Moreover, we show that irregular migration finds a way to carve out a place in receiving societies, circumventing controls or enjoying tolerance, because it is situated at the intersection among different societal factors. Among them, together with labour market’s demand, solidarity by civil societies warrants attention. We use the concept of ‘debordering solidarity’ to indicate the solidarity that overcomes the distinction between citizens and non-citizens, authorised and non-authorised migrants, and that gives priority to human rights and people’s needs.
Datafizierte Gesellschaft | Bildung | Schule
Authors: Breiter Andreas , Bock Annekatrin 
Published: May 2023

ZusammenfassungMit dem Buch „Die datafizierte Schule“ beschreiben wir Datafizierung als einen gesellschaftlichen Metatrend im Kontext von Digitalisierung und als Prozess, in dessen Verlauf Entscheidungen in verschiedenen Akteurskonstellationen im Schulsystem (im Unterricht, von Lehrkräften, von der Schulleitung, der Schulaufsicht, von Dienstleistern und Providern) basierend auf digitalen Daten geprägt, getroffen und verändert werden. Die Wahl des Schulsystems ist dadurch begründet, dass die Schule einerseits bereits durch Daten gestützt gesteuert (datafiziert) wird und andererseits der gesellschaftliche Wandel durch die digitale Transformation erhebliche Wechselwirkungen auf das Handeln in Schule und ihrem Umfeld hat. Ziel der Beiträge ist es, aus verschiedenen Perspektiven, die Ambivalenzen, Spannungen und Brüche, die bei der Produktion, Sammlung, Distribution und Verwendung von schulischen digitalen Daten zu Tage treten, anhand von empirischem Material zu rekonstruieren. Zu dem diskutieren einzelne Kapitel die methodisch-methodologischen Herausforderungen, derer sich Datafizierungsforschung im Schulsystem stellen muss. An den Schnittstellen von Unterrichtspraktiken, Schulmanagement, Schulsteuerung bis zur Softwareproduktion schließen unsere Betrachtungen an Forschungen an, die sich aus einer Perspektive der kritischen Datenstudien (critical data studies) mit datafizierter Gesellschaft und Bildung auseinandersetzen. Mit unserem qualitativen, schnittstellenübergreifenden, interdisziplinären methodischen Ansatz reagieren wir auf Methodenappelle der kritischen Datenstudien. Dabei liegt unser Fokus auf Ambivalenzen quer zu den Themenfeldern bisheriger kritischer Forschung, erweitert deren Perspektive und zielt darauf ab, durch das Aufzeigen von Ambivalenzen, Komplexität und Spannungen Gesprächs- und Denkanstöße zu gesellschaftspolitischen Implikationen der Datafizierung von Schule zu geben. Indem wir auf die Ambivalenzen blicken, die durch Datafizierung hervorgebracht werden und wiederum selbst Datafizierung hervorbringen, diskutieren wir kritisch-abwägend den Umgang mit Daten und den Blick auf Datenpraktiken und laden jene, an Daten und Datafizierung interessierte Forscher*innen wie Bildungspraktiker*innen, dazu ein, über unterschiedliche Umgänge mit Daten in einer datafizierten Schule nachzudenken und dabei diverse Zukünfte von datafizierter Schule zu reflektieren.
Economic Instruments
Authors: Ong Corinne , Tortajada Cecilia , Arora Ojasvee 
Published: May 2023

AbstractWater users’ consumption behaviour may be influenced via economic means such as by offering financial rewards and/or imposing monetary costs. The three most commonly used types of economic instruments are tariff structuring, water rebates, and fines for excessive use. Tariff mechanisms are the most commonly used economic instrument for WDM in ASEAN where several major cities have implemented an increasing block tariff (IBT) system.
Introduction
Authors: Dai Qionghai , Gao Yue 
Published: May 2023

AbstractHigh-order correlations among data exist widely in various practical applications. Compared with the simple graph which can only model the pairwise relationship between two subjects, hypergraph is a flexible and representative model to formulate high-order correlations. Based on the hypergraph model, there have been many efforts to design the computation framework and analyze the high-order correlations. In this chapter, we briefly introduce the hypergraph computation, including its background, definition, history, recent challenges, and objectives.
Isometry groups of six-dimensional nilmanifolds
Authors: Ficzere Kornélia , Figula Ágota 
Published: May 2023

AbstractWe determine the 6-dimensional nilpotent metric Lie algebras such that the Lie algebra $${\mathfrak {n}}$$
n
has a descending series of ideals invariant under all automorphisms of $${\mathfrak {n}}$$
n
and the dimension of the consecutive members of the series decreases by one. We call them metric Lie algebras having a framing determined by ideals. We classify the isometry equivalence classes and determine the isometry groups of connected and simply connected Riemannian nilmanifolds on 6-dimensional nilpotent Lie groups having a Lie algebra $${\mathfrak {n}}$$
n
as their Lie algebra.
Neurofilament accumulations in amyotrophic lateral sclerosis patients’ motor neurons impair axonal initial segment integrity
Authors: Lefebvre-Omar Cynthia , Liu Elise , Dalle Carine , d’Incamps Boris Lamotte , Bigou Stéphanie , Daube Clément , Karpf Léa , Davenne Marc , Robil Noémie , Jost Mousseau Coline , Blanchard Stéphane , Tournaire Guillaume , Nicaise Charles , Salachas François , Lacomblez Lucette , Seilhean Danielle , Lobsiger Christian S. , Millecamps Stéphanie , Boillée Séverine , Bohl Delphine 
Published: May 2023

AbstractAmyotrophic lateral sclerosis (ALS) is the most common motor neuron (MN) disease in adults with no curative treatment. Neurofilament (NF) level in patient’ fluids have recently emerged as the prime biomarker of ALS disease progression, while NF accumulation in MNs of patients is the oldest and one of the best pathological hallmarks. However, the way NF accumulations could lead to MN degeneration remains unknown. To assess NF accumulations and study the impact on MNs, we compared MNs derived from induced pluripotent stem cells (iPSC) of patients carrying mutations in C9orf72, SOD1 and TARDBP genes, the three main ALS genetic causes. We show that in all mutant MNs, light NF (NF-L) chains rapidly accumulate in MN soma, while the phosphorylated heavy/medium NF (pNF-M/H) chains pile up in axonal proximal regions of only C9orf72 and SOD1 MNs. Excitability abnormalities were also only observed in these latter MNs. We demonstrate that the integrity of the MN axonal initial segment (AIS), the region of action potential initiation and responsible for maintaining axonal integrity, is impaired in the presence of pNF-M/H accumulations in C9orf72 and SOD1 MNs. We establish a strong correlation between these pNF-M/H accumulations, an AIS distal shift, increased axonal calibers and modified repartition of sodium channels. The results expand our understanding of how NF accumulation could dysregulate components of the axonal cytoskeleton and disrupt MN homeostasis. With recent cumulative evidence that AIS alterations are implicated in different brain diseases, preserving AIS integrity could have important therapeutic implications for ALS.
Phylogenetic analyses of Candidatus Branchiomonas cysticola refine the taxonomic classification of Betaproteobacteria associated with epitheliocystis in fish
Authors: Bysveen Mjølnerød Even , Lagadec Erwan , Nylund Are 
Published: May 2023

AbstractCandidatus Branchiomonas cysticola is recognized as the most prevalent bacterial agent causing epitheliocystis in Atlantic salmon (Salmo salar). Based on its partial 16S rRNA sequence, the bacterium has previously been found to be a member of Burkholderiales in the class Betaproteobacteria. Multilocus Sequence Analysis (MLSA) of the bacterium and 60 type strains of Betaproteobacteria using newly identified housekeeping genes (dnaK, rpoC, and fusA) and ribosomal subunit sequences (16S and 23S), instead supported the bacterium’s affiliation to Nitrosomodales. Taxonomic rank normalization by Relative Evolutionary Divergence (RED) showed the phylogenetic distinction between Cand. B. cysticola and its closest related type strain to be at the family level. A novel bacterial family named Branchiomonaceae has thus been proposed to include a monophyletic clade of Betaproteobacteria exclusively associated with epitheliocystis in fish.
Automatic characterization of drug/amino acid interactions by energy decomposition analysis
Authors: Ruano Lorena , Mandado Marcos , Nogueira Juan J. 
Published: May 2023

AbstractThe computational study of drug/protein interactions is fundamental to understand the mode of action of drugs and design new ones. In this study, we have developed a python code aimed at characterizing the nature of drug/amino acids interactions in an accurate and automatic way. Specifically, the code is interfaced with different software packages to compute the interaction energy quantum mechanically, and obtain its different contributions, namely, Pauli repulsion, electrostatic and polarisation terms, by an energy decomposition analysis based on one-electron and two-electron deformation densities. The code was tested by investigating the nature of the interaction between the glycine amino acid and 250 drugs. An energy-structure relationship analysis reveals that the strength of the electrostatic and polarisation contributions is related with the presence of small and large size heteroatoms, respectively, in the structure of the drug.
Thermal processing-induced changes in volatilome and metabolome of Brussels sprouts: focus on glucosinolate metabolism
Authors: Wieczorek Martyna N. , Drabińska Natalia , Jeleń Henryk H. 
Published: May 2023

AbstractThis study aimed to investigate the influence of different thermal treatment methods (boiling, steaming) on the metabolome and volatilome of Brussels sprouts. Targeted, quantitative analysis of primary metabolites (amino acids and sugars), glucosinolates as well as untargeted analysis of volatile organic compounds (VOCs) were performed. The composition of primary metabolites was affected only by boiling, where the loss of nutrients was observed. Glucosinolate content increased after cooking, which can be explained by the loosening of the plant tissues and its better extractability. Most marked changes were noticed in the volatilome. Among the degradation products of glucosinolates, isothiocyanates were the main chemical group in the raw and boiled vegetable. In contrast, steaming favored the formation of nitriles. Another dominant group of VOCs were aldehydes, which were the most abundant in raw Brussels sprouts and their level significantly decreased after thermal treatment. It is well known that isothiocyanates are substances with widely proven bioactive properties. Therefore, their formation in the glucosinolate degradation process is favorable. Based on the obtained results, it was concluded that boiling seems to be the most beneficial form of Brussels sprouts’ processing.
Can radiomics be used to detect hypoxic–ischemic encephalopathy in neonates without magnetic resonance imaging abnormalities?
Authors: Zhuang Xiamei , Jin Ke , Lin Huashan , Li Junwei , Yin Yan , Dong Xiao 
Published: May 2023

Abstract
Background
No study has assessed normal magnetic resonance imaging (MRI) findings to predict potential brain injury in neonates with hypoxic–ischemic encephalopathy (HIE).

Objective
We aimed to evaluate the efficacy of MRI-based radiomics models of the basal ganglia, thalami and deep medullary veins to differentiate between HIE and the absence of MRI abnormalities in neonates.

Materials and methods
In this study, we included 38 full-term neonates with HIE and normal MRI findings and 89 normal neonates. Radiomics features were extracted from T1-weighted images, T2-weighted images, diffusion-weighted imaging and susceptibility-weighted imaging (SWI). The different models were evaluated using receiver operating characteristic curve analysis. Clinical utility was evaluated using decision curve analysis.

Results
The SWI model exhibited the best performance among the seven single-sequence models. For the training and validation cohorts, the area under the curves (AUCs) of the SWI model were 1.00 and 0.98, respectively. The combined nomogram model incorporating SWI Rad-scores and independent predictors of clinical characteristics was not able to distinguish HIE in patients without MRI abnormalities from the control group (AUC, 1.00). A high degree of fitting and favorable clinical utility was detected using the calibration curve with the Hosmer−Lemeshow test. Decision curve analysis was used for the SWI, clinical and combined nomogram models. The decision curve showed that the SWI and combined nomogram models had better predictive performance than the clinical model.

Conclusions
HIE can be detected in patients without MRI abnormalities using an MRI-based radiomics model. The SWI model performed better than the other models.

Graphical Abstract
Right Colectomy with Intracorporeal Anastomosis: A European Multicenter Propensity Score Matching Retrospective Study of Robotic Versus Laparoscopic Procedures
Authors: de'Angelis Nicola , Piccoli Micaela , Casoni Pattacini Gianmaria , Winter Des C. , Carcoforo Paolo , Celentano Valerio , Coccolini Federico , Di Saverio Salomone , Frontali Alice , Fuks David , Genova Pietro , Guerrieri Mario , Kraft Miquel , Lakkis Zaher , Le Roy Bertrand , Micelli Lupinacci Renato , Milone Marco , Petri Roberto , Scabini Stefano , Tonini Valeria , Valverde Alain , Zorcolo Luigi , Bianchi Giorgio , Ris Frederic , Espin Eloy ,   For the MERCY Study Collaborating Group Members, Aisoni Filippo , Denet Christine , Antonot Céphise , Vertier Jeanne , Martínez‐Perez Aleix , De Palma Giovanni Domenico , Orci Lorenzo , Bartoletti Sebastiano , O'Connell Lauren , Ortenzi Monica , Pecchini Francesca , Paquet Jean‐Christophe , Chiarugi Massimo , Tartaglia Dario , Perrotto Ornella , Santangelo Antonio , Arces Francesco , De Rosa Raffaele , Andolfi Enrico , de'Angelis Gian Luigi , Carra Maria Clotilde , Pecchini Francesca , Pellino Gianluca , Urbani Alessia , Vidal Laura , Restivo Angelo , Deidda Simona 
Published: May 2023

AbstractBackgroundThis study aimed to compare the short‐ and long‐term outcomes of robotic (RRC‐IA) versus laparoscopic (LRC‐IA) right colectomy with intracorporeal anastomosis using a propensity score matching (PSM) analysis based on a large European multicentric cohort of patients with nonmetastatic right colon cancer.MethodsElective curative‐intent RRC‐IA and LRC‐IA performed between 2014 and 2020 were selected from the MERCY Study Group database. The two PSM‐groups were compared for operative and postoperative outcomes, and survival rates.ResultsInitially, 596 patients were selected, including 194 RRC‐IA and 402 LRC‐IA patients. After PSM, 298 patients (149 per group) were compared. There was no statistically significant difference between RRC‐IA and LRC‐IA in terms of operative time, intraoperative complication rate, conversion to open surgery, postoperative morbidity (19.5% in RRC‐IA vs. 26.8% in LRC‐IA; p = 0.17), or 5‐yr survival (80.5% for RRC‐IA and 74.7% for LRC‐IA; p = 0.94). R0 resection was obtained in all patients, and > 12 lymph nodes were harvested in 92.3% of patients, without group‐related differences. RRC‐IA procedures were associated with a significantly higher use of indocyanine green fluorescence than LRC‐IA (36.9% vs. 14.1%; OR: 3.56; 95%CI 2.02–6.29; p < 0.0001).ConclusionWithin the limitation of the present analyses, there is no statistically significant difference between RRC‐IA and LRC‐IA performed for right colon cancer in terms of short‐ and long‐term outcomes.
Pelvic lymph node dissection for cervical or bladder cancer: embedding residual fat tissue offers no added value
Authors: Vaneman Jasmijn , van Beekhuizen Heleen J. , Boormans Joost L. , Ewing-Graham Patricia C. , van Leenders Geert J. L. H. , Smolders Ramon G. V. , van Doorn H C. 
Published: May 2023

AbstractDiagnosis of lymph node metastases in pelvic lymph node dissection (PLND) is important for staging and treatment. Standard practice is to submit visible or palpable lymph nodes for histology. We assessed the added value of embedding all residual fatty tissue.Patients (n = 85) who underwent PLND for cervical (n = 50) or bladder cancer (n = 35) between 2017 and 2019 were included. Study approval was obtained (MEC-2022-0156, 18.03.2022, retrospectively registered).The median lymph node yield with conventional pathological dissection was 21 nodes (Interquartile range (IQR) 18–28). This led to discovery of positive lymph nodes in 17 (20%) patients. Extended pathological assessment found 7 (IQR 3-12) additional nodes, but did not result in identification of more node metastases.Histopathological analysis of residual fatty tissue harvested at PLND resulted in an increased lymph node yield, but not in the detection of additional lymph node metastases.