bluuebunny/crossref_metadata_2025_split huggingface dataset:
451-P: Perivascular Adipose Tissue Remodeling Modulates Vascular Mitochondrial Metabolism
Authors: KELLER AMY C. , HENCKEL MELISSA M. , KNAUB LESLIE , POTT GREGORY , JAMES GEORGIA , WALKER LORI A. , REUSCH JANE E.B. 
Published: June 2023

Diabetes increases cardiovascular disease (CVD) risk. Diabetes-mediated vascular pathology proceeds differently in men and women. We reported that housing rats at thermoneutral (30°C, TN) conditions alters perivascular adipose tissue (PVAT) phenotype. We also observed related abnormalities in vasoreactivity and mitochondrial function with sex-differences. We hypothesized that TN-mediated PVAT phenotypic transformation alters brown adipose tissue (BAT) regulator PRDM16, fatty acid composition, fatty acid (FA) transporter FATP1, and mitochondrial lipid oxidation in a sex-dependent manner. Male and female Wistar rats were housed at room temperature (24°C, RT) or TN for 16 weeks. Endpoints included PVAT phenotypic characterization, RNA seq analysis, and PVAT mitochondrial respiration. PVAT phenotype was morphologically different between TN and RT rats, with rats housed at TN having 19.7% less BAT phenotype overall (p&lt;0.05). UCP-1 expression was lower in animals housed at TN (p=0.06). PRDM16 was significantly dampened in all animals at TN (p&lt;0.05), and notably decreased in males at TN (80.6%, p&lt;0.05). Loss of BAT markers was associated with changes in FA regulation. Genomic expression of FATP1 was lower in all animals at TN, more prominently in females. Palmitoleic and arachidonic acids were significantly lower in TN females (48.5% and 15.5%, respectively, p&lt;0.05) and males (63.0% and 40.1%, respectively, p&lt;0.05). PVAT of all animals housed at TN showed mitochondrial respiration significantly diminished in lipid substrate experiments for state 3, 4, and uncoupled (p&lt;0.05 for all), aligning with our previous reports in aorta. These data support a model wherein altered PVAT phenotype and FA composition impacts lipid transport and utilization. These changes are associated with differential impact on vascular impairment between females and males. These results provide insights into sex differences in PVAT contributions to vascular disease progression and vascular crosstalk.

Disclosure
A.C.Keller: None. M.M.Henckel: None. L.Knaub: None. G.Pott: None. G.James: None. L.A.Walker: None. J.E.B.Reusch: Advisory Panel; Medtronic.

Funding
National Center for Research Resources (UL1RR025780); U.S. Department of Veterans Affairs (BX002046 to J.E.B.R.), (BX003185 to A.C.K.); National Institutes of Health (R01 DK124344-01A1 to J.E.B.R.); Denver Research Institute; Ludeman Family Center for Women’s Health Research at the University of Colorado Anschutz Medical Campus; Junior Faculty Research Development Grant (to A.C.K.)
454-P: Risk Stratification of Cerebrocardiovascular Disease (CVD) according to HbA1c, Fasting Plasma Glucose (FPG), and Their Combinations in People with Prediabetes (preDM)
Authors: MURAI KOSHIRO , FUJIHARA KAZUYA , YAGUCHI YUTA , YAMADA MAYUKO H. , MATSUBAYASHI YASUHIRO , KITAZAWA MASARU , YAMAMOTO MASAHIKO , YAMADA TAKAHO , KODAMA SATORU , IWANAGA MIDORI , SONE HIROHITO 
Published: June 2023

Association between preDM, defined by HbA1c or FPG alone, and CVD has remained controversial whereas impaired glucose tolerance (IGT) defined according to 2-h blood glucose level in the oral glucose tolerance test has been consistently associated with CVD. However, a glucose tolerance test is not practical in all persons. Thus, we attempted to identify a high-risk group for CVD in those with PreDM using HbA1c and FPG combinations. We analyzed data from a nationwide claims database on 1,140,096 Japanese with no CVD history or glucose abnormality from 2008 to 2022. Multivariate Cox regression analysis showed that compared with normal HbA1c (≤5.6%), CVD risk increased significantly and linearly from HbA1c 5.9% to HbA1c 6.8% in the diabetic range. Conversely, compared with normal FPG (70-99 mg/dl), CVD risk did not increase in the preDM range at each FPG level. Analysis of combinations of HbA1c and FPG showed that with FPG levels 70-99 mg/dl compared with HbA1c ≤5.6%, those with HbA1c 6.0-6.4% had an increased risk of CVD. Risk was higher than with HbA1c 6.5-6.8% (hazard ratio [HR] 1.30 [95% CI 1.11-1.52], 1.11 [0.63-1.96]) (Table). Results suggest that preDM with high HbA1c and normal FPG might have potential postprandial hyperglycemia or lack treatment interventions due to undiagnosed diabetes, which could increase risk of CVD.

Disclosure
K.Murai: None. M.Iwanaga: None. H.Sone: Research Support; Novo Nordisk, Astellas Pharma Inc., Kyowa Kirin Co., Ltd., Taisho Pharmaceutical Holdings Co., Ltd., Ono Pharmaceutical Co., Ltd., Eisai Co., Ltd., Takeda Pharmaceutical Co., Ltd. K.Fujihara: None. Y.Yaguchi: None. M.H.Yamada: None. Y.Matsubayashi: None. M.Kitazawa: None. M.Yamamoto: None. T.Yamada: None. S.Kodama: None.
459-P: Remnant Cholesterol and the Presence of Coronary Artery Disease Are Mutually Independent Predictors for the Development of Type 2 Diabetes Mellitus
Authors: PLATTNER THOMAS , VONBANK ALEXANDER , MADER ARTHUR , SPRENGER LUKAS , MAECHLER MAXIMILIAN , LARCHER BARBARA , LEIHERER ANDREAS , MUENDLEIN AXEL , DREXEL HEINZ , SAELY CHRISTOPH H. 
Published: June 2023

Remnant cholesterol is a predictor of cardiovascular event risk and is associated with the metabolic syndrome as well as with type 2 diabetes (T2DM). Whether this lipid parameter also predicts incident diabetes in subjects who do not yet have diabetes is less clear. We therefore prospectively recorded incident diabetes over 4 years in 864 consecutive nondiabetic Caucasian patients who underwent coronary angiography for the evaluation of established or suspected stable coronary artery disease (CAD). Diabetes was diagnosed according to ADA criteria. At baseline, 54.4% of our patients had significant CAD with lumen narrowing ≥50% at angiography; remnant cholesterol was significantly higher in patients with than in those without significant CAD (24±24 vs 19±18 mg/dl; p&lt;0.001). During follow-up, diabetes was newly diagnosed in 87 patients, i.e. in 10.1% of the study population. Remnant cholesterol strongly predicted diabetes both univariately (OR 1.50 [1.23-1.82]; p&lt;0.001) and after multivariate adjustment including both fasting glucose and HbA1c values (OR 1.47 [1.18-1.80]; p&lt;0.001). When we further adjusted for the presence of significant CAD, remnant cholesterol remained predictive of incident diabetes (OR 1.43 [1.15-1.77]; p&lt;0.001), while CAD predicted incident diabetes in this model independently of remnant cholesterol (OR 1.88 [1.17-3.00]; p=0.009). We conclude that remnant cholesterol and the presence of CAD are mutually independent predictors for the development of T2DM.

Disclosure
T. Plattner: None. A. Vonbank: None. A. Mader: None. L. Sprenger: None. M. Maechler: None. B. Larcher: None. A. Leiherer: None. A. Muendlein: None. H. Drexel: None. C.H. Saely: None.
463-P: Risk Stratification of Coronary Artery Disease (CAD) according to LDL-C, HDL-C Levels, and Glucose Status
Authors: YAMADA MAYUKO H. , FUJIHARA KAZUYA , OSAWA TAEKO , KITAZAWA MASARU , YAGUCHI YUTA , SATO TAKAAKI , MITSUMA YURIE , YAMAMOTO MASAHIKO , MATSUBAYASHI YASUHIRO , IWANAGA MIDORI , YAMADA TAKAHO , KODAMA SATORU , SONE HIROHITO 
Published: June 2023

Whereas elevated LDL-C is a major risk factor for CAD, the inverse association between HDL-C levels and risk of CAD is well-known. Although insulin resistance, and glucose intolerance are associated with low HDL-C levels, it is not clear whether the association of LDL-C with CAD differs depending on glucose status and HDL-C values. We examined associations of LDL-C with the incidence of CAD according to HDL-C and glucose status using a nationwide claims database on 1,524,289 individuals during 2008-2019 with no history of CAD or familial hypercholesterolemia. Cox proportional hazards model identified risks of CAD events among combinations of 3 levels of HDL-C and 7 levels of LDL-C according to glucose status. During a mean follow-up period of 5.5 years, 8,301 CAD events occurred. CAD risk increased from lower LDL-C levels accompanied by lower HDL-C levels regardless of glucose status (Table). Even in people with LDL-C &lt;80mg/dl, HDL-C &lt;40mg/dl conferred 2.5-fold increased risk of CAD all glucose status. HDL-C and LDL-C values had a synergistic effect on the incidence of CAD in people with normoglycemia, whereas an addictive effect in people with prediabetes and diabetes. Although more strict LDL-C target need to be achieved as worsening of glucose status, results demonstrated that the necessity of modulating the LDL-C target according to HDL-C levels is not affected by glucose status.

Disclosure
M.H.Yamada: None. M.Iwanaga: None. T.Yamada: None. S.Kodama: None. H.Sone: Research Support; Novo Nordisk, Astellas Pharma Inc., Kyowa Kirin Co., Ltd., Taisho Pharmaceutical Holdings Co., Ltd., Ono Pharmaceutical Co., Ltd., Eisai Co., Ltd., Takeda Pharmaceutical Co., Ltd. K.Fujihara: None. T.Osawa: None. M.Kitazawa: None. Y.Yaguchi: None. T.Sato: None. Y.Mitsuma: None. M.Yamamoto: None. Y.Matsubayashi: None.
465-P: Anti-inflammatory Therapies in Patients with Established Cardiovascular Disease or High Cardiovascular Risks
Authors: LIN CHU , LI ZONGLIN , CAI XIAOLING , JI LINONG 
Published: June 2023

Background: To evaluate the association between anti-inflammatory therapies and the incidence of cardiovascular events in patients with established cardiovascular disease (CVD) or high cardiovascular risks.
Methods: Literature retrieval was conducted in Pubmed, Medline, Embase, the Cochrane Central Register of Controlled Trials and Clinicaltrial.gov website from the inception to July 2022. Randomized controlled trials compared anti-inflammatory therapies with placebo in patients with established CVD or high cardiovascular risks were included. The results of the meta-analysis were computed as the odds ratio (OR) with 95% confidence interval (CI).
Results: Compared with placebo, anti-inflammatory therapies were associated with decreased incidence of myocardial infarction (MI) (OR=0.93, 95%CI, 0.87 to 0.98), which was mainly driven by therapies targeting central IL-6 signaling pathway (OR=0.84, 95%CI, 0.76 to 0.94). IL-1 inhibitors treatment was associated with reduced risks of heart failure (OR=0.32, 95%CI, 0.14 to 0.76) while lower incidence of stroke was observed in patients with colchicine treatment (OR=0.46, 95%CI, 0.28 to 0.77). MI events were less frequent in patients over 65 years old (OR=0.90, 95%CI, 0.82 to 0.98) or with follow-up duration over 1 year (OR=0.90, 95%CI, 0.84 to 0.96)when comparing anti-inflammatory therapies with placebo.
Conclusion: Anti-inflammatory therapies, especially those targeting central IL-6 signaling pathway may serve as promising treating strategies to ameliorate the risk of MI. Meanwhile, IL-1 inhibitor and colchicine were associated with decreased risks of heart failure and stroke respectively. MI risk reductions by anti-inflammatory therapies seem to be more prominent in patients who were elderly and with long follow-up duration.

Disclosure
C.Lin: None. Z.Li: None. X.Cai: None. L.Ji: Other Relationship; Eli Lilly and Company, Novo Nordisk, Merck & Co., Inc., Bayer Inc., Sanofi-Aventis U.S., Roche Pharmaceuticals, MSD Life Science Foundation, AstraZeneca, Boehringer Ingelheim Inc., Abbott, Metronics.

Funding
National Natural Science Foundation of China (81970698, 81970708); Beijing Natural Science Foundation (7202216)
47-LB: Inverse Association of Vegetable Consumption with Nonalcoholic Fatty Liver Disease in Chinese Patients with Type 2 Diabetes Mellitus
Authors: GU XUEJIANG 
Published: June 2023

Objective: We aimed to investigate the association of fruit and vegetable consumption with nonalcoholic fatty liver disease (NAFLD) in Chinese patients with type 2 diabetes mellitus (T2DM).
Methods: This cross-sectional study included 2667 Chinese patients with T2DM aged 18 to 76 years. Dietary intake was assessed by food frequency questionnaire, and prevalent NAFLD was diagnosed with abdominal ultrasonography. The primary outcome measurement was multivariate-adjusted odds ratios (ORs) with 95% confidence intervals (CIs) for the prevalence of NAFLD in relation to the highest fruit and (or) vegetable intake compared with the lowest. Secondary analyses were conducted to assess the effects of either fruit or vegetable intake on the fatty liver index (FLI) using multivariable linear regressions.
Results: There were 1445 (54.06%) participants had prevalent NAFLD in this study. Patients with high fruit-vegetable intake (≥500 g/day) had a lower prevalence of NAFLD (52.04% vs. 56.48%), but this difference was not statistically significant (p = 0.065). Vegetable intake had a significantly inverse association with NAFLD (OR: 0.68, 95% CI: 0.52-0.90), but this association was not pronounced with fruit intake (OR: 1.23, 95% CI: 0.89-1.69) or fruit-vegetable intake (OR: 0.90, 95% CI: 0.73-1.10). Additional analyses showed that an increase in vegetable intake was linearly associated with a significant reduction in FLI (β: −1.028, 95% CI: −1.836, −0.219).
Conclusions: Higher vegetable consumption was associated with lower odds of NAFLD in Chinese patients with T2DM, which suggested that increased vegetable intake might protect patients with diabetes against NAFLD.

Disclosure
X. Gu: None.
470-P: Elevated NT-ProBNP Is Associated with Significant CT Left Anterior Descending Coronary Artery Calcification Score in T2DM
Authors: GUPTA VISHAL , TELI VAISHALI 
Published: June 2023

Aims & Objectives: Establish the relationship between N-terminal Pro B-type natriuretic peptide (NT-ProBNP) & CT-Coronary calcium score (CAC) in patients with T2DM.
Methodology: Between Oct'19 & Dec'19, 62 asymptomatic T2DM patients, aged 18-75yrs, irrespective of A1c, on regular F/U who had NT-ProBNP ≥ 125pg/ml (Group-G1) & who had undergone CAC & 2D-Echocardiogram (2D) were retrospectively analysed & compared to 62 T2DM patients (Group-G2) with corresponding NT-ProBNP &lt; 125 along with CAC & 2D. Cardio-renal (CR) biomarkers & CAC were compared at the point NT-ProBNP ≥ 125 for Gr-1 with Gr-2. Patients with only preserved ejection fraction (EF) were included. Patients were receiving standard glucose lowering, lipid lowering & BP lowering therapy optimised for CR biomarkers (BMI, HbA1c, Systolic-BP, Diastolic-BP, Lipid profile, highly sensitive C-reactive protein {HSCRP}, Creatinine, urine microalbumin/creatinine ratio {UACR}). Exclusion: low-EF, H/O of IHD, recent (&lt;6mths) hospitalisation &/or coronary intervention. Data analysis: SPSS version 26 & represented as Mean ± 2(SD) with 95% Cl. Pearson co-relation was used & p-value &lt;0.05 was considered significant (S).
Results: There was a S difference between Gr-1 & Gr-2 in mean Age yrs (Gr1: 64.35 ± 6.874yrs Vs Gr2: 61.15 ± 6.840, p-0.010), BMI kg/m2 (Gr1: 32.25 ± 5.59 Vs Gr2: 29.66 ± 4.81, p-0.007), NT-ProBNP pg/ml (Gr1: 167.31 ± 159.46 Vs Gr2: 33.98 ± 20.64, p-0.000) & CAC score HU {LAD: Gr1: 286.35 ± 376.83 Vs Gr2: 167.63 ± 234.47, p-0.0393). Total CAC between both groups (Gr1: 471.13 ± 622.81 Vs Gr2: 420.92 ± 659.77, p-0.6638) remained non-significant. There was also no difference seen in SBP, DBP, Lipid Profile (TC, LDL, TG, HDL, Apo B), hs-CRP, serum creatinine, eGFR & UACR.
Conclusion: NT-ProBNP ≥125 is related to greater CAC in LAD & may represent an ischemic signal requiring optimal cardiovascular risk factor management inT2DM patients. These patients are older & have a greater BMI.

Disclosure
V.Gupta: None. V.Teli: None.
471-P: The Visceral Adiposity Index Predicts MACE Both in Cardiovascular Disease Patients with and in Those without Diabetes
Authors: MAECHLER MAXIMILIAN , SPRENGER LUKAS , MADER ARTHUR , LARCHER BARBARA , VONBANK ALEXANDER , PLATTNER THOMAS , LEIHERER ANDREAS , MUENDLEIN AXEL , DREXEL HEINZ , SAELY CHRISTOPH H. 
Published: June 2023

The Visceral Adiposity Index (VAI) is calculated based on waist circumference, BMI, triglyzeride and HDL-cholesterol levels and is a validated measure of visceral adiposity. In the general population, the VAI has been shown to be an independent risk factor for premature mortality. Its power to predict MACE in patients with established cardiovascular disease (CVD) with or without type 2 diabetes mellitus (T2DM) is not known and is addressed in the present study. We prospectively recorded MACE in 601 of 1499 patients with either angiographically diagnosed CAD (n=1261) or sonographically verified PAD (n=238) over a mean follow-up time of 9.6±5.1 years. At baseline, the VAI was significantly higher in patients with T2DM (n=489) than in those who did not have diabetes (6.7±6.0 vs. 4.7±4.5; p&lt;0.001). Prospectively, the VAI significantly predicted the incidence of MACE both univariately (standardized HR 1.01 [1.00-1.03]; p=0.037) and after adjustment for age, gender, smoking, LDL cholesterol, hypertension and T2DM (standardized adjusted HR 1.01 [1.00-1.03]; p=0.011); also T2DM significantly predicted MACE in this fully adjusted model (adjusted HR 1.55 [1.31-1.84]; p&lt;0.001). We conclude that the VAI and T2DM are mutually independent predictors of MACE in patients with CVD.

Disclosure
M.Maechler: None. C.H.Saely: None. L.Sprenger: None. A.Mader: None. B.Larcher: None. A.Vonbank: None. T.Plattner: None. A.Leiherer: None. A.Muendlein: None. H.Drexel: None.
473-P: Differences in Carotid Arteriosclerosis according to Waist Circumference and Thigh Circumference Appear Differently in Diabetic Patients and Prediabetic Patients
Authors: SIK KIM CHUL , JANG SEOL A. , MIN KIM KYOUNG , WON PARK SEOK 
Published: June 2023

This study investigated the relationships of thigh and waist circumference with the glycemic variability and carotid atherosclerosis in patients with type 2 diabetes mellitus (T2DM) and prediabetes. This observational study included 3,453 Korean patients with T2DM and prediabetes, in whom anthropometric measurements and carotid ultrasonography were conducted. Carotid plaque was defined as focal structures encroaching the arterial lumen by ≥ 0.5 mm or 50% of the surrounding IMT value or a thickness ≥1.5 mm. In men with T2DM, it was found that the larger the thigh circumference, the lower the risk of carotid plaque after adjustment for potential confounding variables. In women with T2DM, a similar tendency was observed before adjustment, but no statistically significant relationship was seen after adjustment. In women with T2DM, the presence of carotid plaque was higher in the thickest waist group compared to the reference group, but there is no statistical significance after adjustment. However, no difference in carotid arteriosclerosis according to waist and thigh circumference was found in both men and women in prediabetic patients. It suggests that the risk of cardiovascular disease according to the difference in body type such as waist circumference and thigh thickness may appear differently depending on the glucose status. However, further longitudinal studies are warranted.

Disclosure
C.Kim: None. S.A.Jang: None. K.Kim: None. S.Park: None.
488-P: Subclinical Autonomic Neuropathy in Uncomplicated Type 2 Diabetes
Authors: JOHNSTON ASPEN , ABUSHAMAT LAYLA A. , ENGE DANIEL , BARKER ALEX J. , CLARK ETHAN W. , RAFFERTY DEIRDRE , REGENSTEINER JUDITH G. , REUSCH JANE E.B. 
Published: June 2023

Cardiac autonomic neuropathy (CAN), a common complication of type 2 diabetes (T2D), is often not detected until late in disease progression. Autonomic nervous system (ANS) dysfunction impairs control of heart rate (HR) and vascular dynamics, manifesting as decreased HR variability (HRV) and impaired blood pressure (BP) regulation. We hypothesized that ANS function is impaired in participants with uncomplicated T2D and correlates with cardiac measures. We measured HRV during cycled breathing and Valsalva and postural HR and BP on overweight physically inactive adults aged 22-70 years with (N=53) and without (N=56) T2D. HRV with cycled breathing and Valsalva was lower in participants with T2D (p=0.007 and 0.005, respectively). HRV with respiration was lower with age &gt;50 years (p=0.0001). HRV with respiration correlated with increased age in T2D but not in overweight control participants. There were no significant changes in postural BP or HR with age &gt;50 years or T2D. Significant correlations between ANS measures and cardiac function were only seen in those with T2D. Valsalva ratio was positively correlated with end-diastolic volume (Pearson’s r 0.58, p=0.02) and stroke volume (Pearson’s r 0.55, p=0.03). HRV with respiration was positively correlated with longitudinal, diastolic peak strain rate (SR) (Pearson’s r 0.68, p=0.007). Postural BP was positively correlated with circumferential and longitudinal, systolic peak SR (Pearson’s r =0.45 and 0.48 and p-value=0.05 and 0.04, respectively) and negatively correlated with radial and circumferential peak strain (Pearson’s r =-0.49 and -0.48 and p-value=0.03 and 0.03, respectively). These data suggest subclinical CAN associated with cardiac dysfunction is present in people with otherwise uncomplicated T2D and is exacerbated with age. Detecting CAN changes early may identify people at risk for cardiac disease and inform targeted intervention to restore cardiometabolic health in people with T2D.

Disclosure
A.Johnston: None. L.A.Abushamat: None. D.Enge: None. A.J.Barker: None. E.W.Clark: None. D.Rafferty: None. J.G.Regensteiner: None. J.E.B.Reusch: Advisory Panel; Medtronic.

Funding
American Diabetes Association (1-21-CMF-003 to L.A.A.); National Institutes of Health (T32DK120520-01A1); U.S. Department of Veterans Affairs (CX001532)
49-OR: Genetic Variants Influencing Insulin Deficiency and Resistance Are Associated with Adverse Pregnancy Outcomes
Authors: HSU SARAH , JAMES KAITLYN , MEDINA BAEZ ARANTXA , SMITH KIRK , MERCADER JOSEP M. , UDLER MIRIAM , POWE CAMILLE E. 
Published: June 2023

Background: We tested maternal genetic determinants of insulin deficiency (ID) and insulin resistance (IR) for association with hyperglycemia-related adverse pregnancy outcomes.
Methods: We applied non-negative matrix factorization to GWAS data (325 type 2 diabetes [T2D]-associated variants, 135 T2D-related traits) to derive 2 trait/variant clusters. We verified associations between cluster polygenic scores (PGSs) and ID/IR-related traits in non-pregnant women (n=35341). In pregnant women (n=1521) we tested for associations between cluster PGSs and infant birthweight (BW) percentile for gestational age and secondary outcomes (gestational diabetes [GDM], large/small for gestational age BW, hypertensive disorders, neonatal ICU admission, preterm birth) using models adjusted for age, insurance, parity, race, and principal components. Effect sizes are for a 1-SD PGS increase.
Results: Cluster 1 had ID-related traits/variants (e.g., decreased insulin response and disposition index, increased fasting glucose, variants near MTNR1B, CDKAL1, C2CD4A/B SLC30A8). Outside pregnancy, the ID cluster PGS was associated with T2D (OR=1.2, p=2×10-7) and HbA1c (β=0.05%, p=2.8×10-9). In pregnancy, the ID cluster PGS was associated with higher BW percentile (β=1.7, p=0.04) and GDM (OR=1.3, p=0.004), but not other outcomes. Cluster 2 had IR-related traits/variants (e.g., decreased HDL and insulin sensitivity, increased triglycerides [TG] and fasting insulin, variants near IRS1, GRB14, LPL, FTO). Outside pregnancy, the IR cluster PGS was associated with T2D (OR=1.1, p=2×10-5), HbA1c (β=0.06 %, p=1.2×10-14), TG (β =4.2 mg/dL, p=4.4×10-15) and inversely associated with HDL (β=-1.7mg/dL, p=5.5×10-32). In pregnancy, the IR cluster PGS was associated with preterm birth (OR=1.3, p=0.006), but not BW percentile or GDM.
Conclusion: Maternal genetic determinants of ID are associated with increased BW; genetic determinants of IR are associated with preterm birth.

Disclosure
S.Hsu: None. K.James: None. A.Medina baez: None. K.Smith: None. J.M.Mercader: None. M.Udler: None. C.E.Powe: Consultant; Mediflix, Inc., Other Relationship; Wolters Kluwer Health.