bluuebunny/crossref_metadata_2025_split huggingface dataset:
La globalisation du moralisme
Authors: Gagné Gilles 
Published: April 2023

Les sciences de la gestion américaines sont à l’heure d’un bilan : quelle est l’efficacité du programme diversité, équité, inclusion (DEI, anciennement D&I) et des programmes similaires adoptés, selon Leslie Sklair, dès les années 1990 par les entreprises globales de haut niveau ? Comment « l’industrie DEI » et « les nouvelles professions de la DEI » pourront-elles généraliser l’augmentation de la compétiti- vité des organisations qui pratiquent la diversité de genre (+21 %) ou la diversité ethnique et de genre (+33 %), ou la capacité des équipes diversifiées (selon l’âge, le genre et l’ethnie) de prendre de meilleures décisions (dans 87 % des cas), comme le soutient le cabinet de consultants internationaux Global Diversity Practice ? Comment les performances des CDO (chief diversity officers) se traduisent-elles dans la société quand on sait que 35 % des investissements émotionnels (?!) des employés sont associés au sentiment d’être inclus, selon une étude de la firme Catalyst en 2020 ? C’est sur le fond de la multiplication des cabinets de tuteurs, de mentors et de coachs internationaux qui implantent ces pratiques managériales que l’article examine les transformations sociales et politiques plus générales qui ont rendu possible la convergence (et la confusion) entre un programme de gestion du personnel visant à accroître les rendements et une quête morale qui tend à légiti- mer une nouvelle forme (verticale) de la démocratie sociale.
The Roles of Fibroblast Growth Factor Receptor 3 (FGFR3) in the Spectrum of Skeletal Dysplasia
Authors: Okikiade Adedeji , Afolayan-Oloye Olayinka , Agboola Rasheed , Oluwatosin Aruwajoye , Sithole Joy , Akinyode Esther , Akoth Annah , Oyewole Adijat , Potts-Johnson Sotonye 
Published: April 2023

The fibroblast growth factor receptor 3 (FGFR3) gene mutations were identified to be involved in the pathogenesis of most chondropathies. The FGFR3 gene encodes the FGFR3 receptor and is involved in the regulation of bone growth by limiting the ossification of long bones. Mutations of the FGFR3 gene result in abnormal cell proliferation and improper cartilage development. We aim to provide an overview of the roles of FGFR3 in skeletal dysplasia by highlighting the pathogenesis, clinical variants of skeletal dysplasia, diagnosis, and their management.
Achondroplasia is the most common form of chondropathies, occurring in approximately 1 in 20,000-30,000 live births, and it is the most common form of genetic dwarfism. In over 80% of cases of achondroplasia, the mutation is sporadic, and only 20% are inherited autosomal dominant. Achondroplasia results from a point mutation in the gene encoding the transmembrane portion of FGFR3. Two viable base substitutions are identified in achondroplasia, including a point mutation of guanine substituted for adenine (c.1138G>A); this is identified in approximately 98% of the affected individuals, and transversion of guanine to cytosine (c.1138G>C).
Hypochondroplasia is a milder form of chondropathies with an incidence between 1 in 33,000 and 1 in 47,000 live births. Missense mutations of FGFR3 (p.Asn540Lys) are isolated in tyrosine kinase domain I occurring in approximately 60% of cases, and missense mutation of FGFR3 (p.Lys650Asn) identified in the tyrosine kinase domain II of FGFR3. Thanatophoric dysplasia is the most lethal form of chondropathies, with neonatal fetal death secondary to pulmonary hypoplasia. In thanatophoric dysplasia, there is Lys650Met substitution in FGFR3 (Type I) with impairment of endochondral bone growth and a pathogenic variant of p.Lys650Glu substitution in FGFR3 (Type II). In addition, specific amino acid substitution in the FGFR3 gene (G380R) was identified to be associated with severe achondroplasia with developmental delay and acanthosis nigricans (SADDAN).
The diagnosis of achondroplasias is routinely made from clinical presentations and radiological findings. FGFR3 molecular genetic testing is performed in children with atypical presentations. In addition, a pre-implantation genetic diagnosis should be available for parents pursuing in-vitro fertilization and embryo implantation procedures. Management of chondropathies includes symptomatic treatment with drugs, surgical intervention, and lifelong follow-up care. Different pharmacological options have been used, including those that directly block FGFR3 activation or regulate signalling pathways controlling chondrocyte proliferation and differentiation.
Isoconversional and Model-fitting Approaches to Kinetic and Thermoanalytic Study of Lanthanum Oxalate: Nonlinear Relationship between Kinetic Parameters
Authors: Nayak Himansulal 
Published: April 2023

The data for the nonisothermal and isothermal thermal decompositions of lanthanum oxalate have been analysed using the model-free and model-fitting kinetic techniques. When applied to nonisothermal data using the Coat-Redfern(CR) equation, the widely used model-fitting approach that results excellent fitting for both isothermal and nonisothermal data but produces very ambiguous values of the Arrhenius parameters. These values cannot be compared to those obtained from isothermal experiments. On the other hand, the model-free strategy represented by the iso-conversional method, such as Flynn-Wall-Ozawa (FWO) and Kissinger-Akahira-Sunose (KAS), emphasize propertionate variation of the activation energy with the degree of conversion for both isothermal and nonisothermal experiments. The model free approach is recommended as a reliable way for obtaining consistent kinetic information from both isothermal and non-isothermal data. Despite their linear correlation, the kinetic parameters do not exhibit isokinetic behaviour. Thus, utilising Nonlinear Compensation Law, a greater association between kinetic triplets was examined.
Investigating the Effect of Infrastructural Development on Economic Growth in Uganda
Authors: Mahebe Dennis , Mugobera Ronald 
Published: April 2023

Aim: The study used quarterly time series data to investigate the effect of infrastructural development on Economic Growth in Uganda.
Place and Duration of Study: the study utilized data for the period between 2005-2020 obtained from the 2022 World Bank’s World Development Indicators (WDI) and the African Development Bank for African Infrastructure Development Index (AIDI).
Methodology: The study used the Autoregressive Distributed Lag (ARDL) model to analyze the relationship between infrastructure development and Economic Growth in Uganda.
Results: The findings from the study indicated a positive relationship between AIDI and Economic growth in Uganda. Overall improvement in AIDI considering the four infrastructure components creates an enabling environment for other factors of production to operate effectively and efficiently hence spurring economic growth in the country.
Conclusion: The findings therefore implies that investment in infrastructure should consider all the four infrastructure components that comprise the AIDI namely, Transport, Electricity, ICT and Water and Sanitation for Uganda to be able to fully benefit from its investment in infrastructure in both the short and long run.
The Delineation of Watersheds in the Dhenkanal District, Odisha, India; Using Arc-GIS
Authors: Mishra Siba Prasad , Nayak Jasmini , Barik Kamal Kumar , Sethi Kumar Ch. 
Published: April 2023

The watersheds of the Dhenkanal district of Odisha, India with the centrally flowing, river Brahmani identified and explored. The watersheds added with anthropogenic stresses are unattended that affect the land, hydrology, ecology, vegetation, and fertility of the soil. Population growth, migration to cities, challenges, continuous disasters, and anthropogenic stresses block the growth.
The Arc GIS software and its Hydrology toolset were utilized. The Digital Elevation Model is used to scale various maps like flow direction, stream order, flow accumulation, Stream features, Pour points, and watershed maps of the district. The Rengali Dam, and Samal barrage of the Brahmani system and its left and right canal system have a positive impact on watersheds on both sides of the river Brahmani but the surface and groundwater are polluted by industrial effluents.
The watersheds in transition ridges of the Mahanadi and the Baitarani basin of the Brahmani basin have been poorly attended in Dhenkanal. Construction of farm ponds, groundwater recharge units, soil conservation activities, renovation, and new construction of waterbodies can cater to and care for the land, water, and vegetation of the district. It is high time to prepare large-scale maps by modern survey techniques (UAV, drones, GIS, and GPS) and the observed data used to identify, delineate, prioritize, and plan for sustainable environment management considering availability v/s demand of water through Integrated Watershed Management in the district.
Anatomic Locations of Procedurally Treated Keratinocyte Carcinomas in the US Medicare Population
Authors: Navsaria Lucy J. , Li Yao , Tripathy Sanjna , Cox Madisyn L. , Hinkston Candice L. , Margolis David J. , Wehner Mackenzie R. 
Published: April 2023

ImportanceKeratinocyte carcinomas are the most common cancers in the US. However, keratinocyte carcinomas are not included in US national cancer registries, and information on the anatomic locations of keratinocyte carcinomas is lacking.ObjectiveTo investigate the anatomic location of keratinocyte carcinomas in the US using a large claims data set.Design, Setting, and ParticipantsWe performed a cohort study using a deidentified, random sample of 4 999 999 fee-for-service Medicare beneficiaries aged 65 years or older (2009-2018).Main Outcomes and MeasuresProportion of procedurally treated keratinocyte carcinomas at each anatomic location, identified by linking diagnosis and treatment codes.ResultsA total of 2 415 514 keratinocyte carcinomas were identified in 792 393 beneficiaries. The mean (SD) age was 76.6 (8.1) years, 410 364 (51.8%) were women, and 96.7% were White. Of the 2 415 514 keratinocyte carcinomas, 796 542 could be subtyped into basal cell carcinoma (33.0%), 927 984 into squamous cell carcinoma (38.4%), and 690 988 (28.6%) could not be subtyped. The most common location of squamous cell carcinomas was the head and/or neck (44.3%) followed by upper limbs (26.7%). The most common location of basal cell carcinomas was head and/or neck (63.8%), followed by trunk (14.9%). In women, keratinocyte carcinomas were most common on the head and/or neck (47.3%) followed by upper and lower limb (18.5% and 16.6%, respectively). In men, keratinocyte carcinomas were most common on the head and/or neck (58.7%) followed by upper limb and trunk (17.3% and 11.4%, respectively).Conclusions and RelevanceThe results of this large Medicare cohort study highlight the anatomic locations of keratinocyte carcinomas over recent years and show the predominance of lesions occurring at head and/or neck anatomic location. This foundational information on keratinocyte carcinoma anatomic locations in the US is valuable for improved keratinocyte risk factor differentiation and skin cancer surveillance.
Etiology, Diagnosis, and Modern Management of Chronic Pancreatitis
Authors: Cohen Stephanie M. , Kent Tara S. 
Published: April 2023

ImportanceThe incidence of chronic pancreatitis is 5 to 12 per 100 000 adults in industrialized countries, and the incidence is increasing. Treatment is multimodal, and involves nutrition optimization, pain management, and when indicated, endoscopic and surgical intervention.ObjectivesTo summarize the most current published evidence on etiology, diagnosis, and management of chronic pancreatitis and its associated complications.Evidence ReviewA literature search of Web of Science, Embase, Cochrane Library, and PubMed was conducted for publications between January 1, 1997, and July 30, 2022. Excluded from review were the following: case reports, editorials, study protocols, nonsystematic reviews, nonsurgical technical publications, studies pertaining to pharmacokinetics, drug efficacy, pilot studies, historical papers, correspondence, errata, animal and in vitro studies, and publications focused on pancreatic diseases other than chronic pancreatitis. Ultimately, the highest-level evidence publications were chosen for inclusion after analysis by 2 independent reviewers.FindingsA total of 75 publications were chosen for review. First-line imaging modalities for diagnosis of chronic pancreatitis included computed tomography and magnetic resonance imaging. More invasive techniques such as endoscopic ultrasonography allowed for tissue analysis, and endoscopic retrograde cholangiopancreatography provided access for dilation, sphincterotomy, and stenting. Nonsurgical options for pain control included behavior modification (smoking cessation, alcohol abstinence), celiac plexus block, splanchnicectomy, nonopioid pain medication, and opioids. Supplemental enzymes should be given to patients with exocrine insufficiency to avoid malnutrition. Surgery was superior to endoscopic interventions for long-term pain control, and early surgery (&amp;lt;3 years from symptom onset) had more superior outcomes than late surgery. Duodenal preserving strategies were preferred unless there was suspicion of cancer.Conclusions and RelevanceResults of this systematic review suggest that patients with chronic pancreatitis had high rates of disability. Strategies to improve pain control through behavioral modification, endoscopic measures, and surgery must also accompany management of the sequalae of complications that arise from endocrine and exocrine insufficiency.
Association of Health Care Utilization and Access to Care With Vascular Assessment Before Major Lower Extremity Amputation Among US Veterans
Authors: Alabi Olamide , Beriwal Surabhi , Gallini Julia W. , Cui Xiangqin , Jasien Christine , Brewster Luke , Hunt Kelly J. , Massarweh Nader N. 
Published: April 2023

ImportancePatient-level characteristics alone do not account for variation in care among US veterans with peripheral artery disease (PAD). Presently, the extent to which health care utilization and regional practice variation are associated with veterans receiving vascular assessment prior to major lower extremity amputation (LEA) is unknown.ObjectiveTo assess whether demographics, comorbidities, distance to primary care, the number of ambulatory clinic visits (primary and medical specialty care), and geographic region are associated with receipt of vascular assessment prior to LEA.Design, Setting, and ParticipantsThis national cohort study used US Department of Veterans Affairs’ Corporate Data Warehouse data from March 1, 2010, to February 28, 2020, for veterans aged 18 or older who underwent major LEA and who received care at Veterans Affairs facilities.ExposuresThe number of ambulatory clinic visits (primary and medical specialty care) in the year prior to LEA, geographic region of residence, and distance to primary care.Main Outcomes and MeasuresThe main outcome was receipt of a vascular assessment (vascular imaging study or revascularization procedure) in the year prior to LEA.ResultsAmong 19 396 veterans, the mean (SD) age was 66.78 (10.20) years and 98.5% were male. In the year prior to LEA, 8.0% had no primary care visits and 30.1% did not have a vascular assessment. Compared with veterans with 4 to 11 primary care clinic visits, those with fewer visits were less likely to receive vascular assessment in the year prior to LEA (1-3 visits: adjusted odds ratio [aOR], 0.90; 95% CI, 0.82-0.99). Compared with veterans who lived less than 13 miles from the closest primary care facility, those who lived 13 miles or more from the facility were less likely to receive vascular assessment (aOR, 0.88; 95% CI, 0.80-0.95). Veterans who resided in the Midwest were most likely to undergo vascular assessment in the year prior to LEA than were those living in other regions.Conclusions and RelevanceIn this cohort study, health care utilization, distance to primary care, and geographic region were associated with intensity of PAD treatment before LEA, suggesting that some veterans may be at greater risk of suboptimal PAD care practices. Development of clinical programs, such as remote patient monitoring and management, may represent potential opportunities to improve limb preservation rates and the overall quality of vascular care for veterans.
Hazard testing to reduce risk in the development of automated planning tools
Authors: Nealon Kelly A. , Douglas Raphael J. , Han Eun Young , Kry Stephen F. , Reed Valerie K. , Simiele Samantha J. , Court Laurence E. 
Published: April 2023

AbstractPurposeHazard scenarios were created to assess and reduce the risk of planning errors in automated planning processes. This was accomplished through iterative testing and improvement of examined user interfaces.MethodsAutomated planning requires three user inputs: a computed tomography (CT), a prescription document, known as the service request, and contours. We investigated the ability of users to catch errors that were intentionally introduced into each of these three stages, according to an FMEA analysis. Five radiation therapists each reviewed 15 patient CTs, containing three errors: inappropriate field of view, incorrect superior border, and incorrect identification of isocenter. Four radiation oncology residents reviewed 10 service requests, containing two errors: incorrect prescription and treatment site. Four physicists reviewed 10 contour sets, containing two errors: missing contour slices and inaccurate target contour. Reviewers underwent video training prior to reviewing and providing feedback for various mock plans.ResultsInitially, 75% of hazard scenarios were detected in the service request approval. The visual display of prescription information was then updated to improve the detectability of errors based on user feedback. The change was then validated with five new radiation oncology residents who detected 100% of errors present. 83% of the hazard scenarios were detected in the CT approval portion of the workflow. For the contour approval portion of the workflow none of the errors were detected by physicists, indicating this step will not be used for quality assurance of contours. To mitigate the risk from errors that could occur at this step, radiation oncologists must perform a thorough review of contour quality prior to final plan approval.ConclusionsHazard testing was used to pinpoint the weaknesses of an automated planning tool and as a result, subsequent improvements were made. This study identified that not all workflow steps should be used for quality assurance and demonstrated the importance of performing hazard testing to identify points of risk in automated planning tools.
Spoiler alert: How narrative film captures attention
Authors: Cohen Anna‐Lisa , Goldberg Chaim , Mintz Jonathan , Shavalian Elliot 
Published: April 2023

AbstractNarrative transportation is a state of total immersion that arises when one becomes engaged in a story. In Cohen et al. (2015), participants viewed a suspenseful film either with order of scenes intact or scrambled (out of chronological order). Participants had to remember to raise their hand every time they heard a film character say the word “gun.” Results revealed participants were less likely to remember this instruction in the intact condition because their attention shifted away from processing their own goals to the goals of the protagonist. In three studies, we examined the boundary conditions of this effect by including a spoiler by telling participants the film ending (Study 1), having participants view the film individually or in groups (Study 2), and offering a reward incentive (Study 3). Overall, results showed that knowing the ending of the story did not improve performance, however, offering an incentive did boost goal maintenance. Implications of these findings are discussed.
2D Cobalt Oxyhydroxide Nanozymes Inhibit Inflammation by Targeting the NLRP3 Inflammasome
Authors: Chen Ziying , Chen Pin , Zhu Yangyang , Qian Jieying , Huang Xiaowan , Zhang Wang , Zhang Hao , Mo Qing , Lu Yutong , Zhang Yunjiao 
Published: April 2023

AbstractNucleotide‐binding domain and leucine rich repeat family pyrin domain containing 3 (NLRP3) inflammasomes are implicated in diverse inflammatory diseases, so their activation needs to be tightly controlled. Over generation of reactive oxygen species (ROS) is a key factor in NLRP3 inflammasome activation. Consequently, nanozymes with ROS scavenging ability are potential inhibitors of NLRP3 activation and promising therapeutic agents for related inflammatory diseases. Herein, a type of 2D cobalt hydroxide oxide nanosheets (Co NSs), a nanozyme with excellent multienzyme‐like activity, possessing peroxidase (POD), catalase (CAT), and superoxide dismutase (SOD) activities, exhibits superior ROS scavenging properties and protects cells from oxidative damage. Density functional theory (DFT) calculations further reveal these enzyme‐like catalytic reactions of ROS eliminating are spontaneous and CAT is dominant under physiological conditions. Performing multienzyme properties, Co NSs present excellent anti‐inflammation activity by blocking NLRP3 oligomerization and ASC speck formation, thereby inhibiting NLRP3 inflammasome assembly and activation. Importantly, treatment with Co NSs attenuates the severity of LPS‐induced systemic inflammation and DSS‐induced colitis. This study highlights a successful strategy for utilizing cobalt‐based nanozymes to scavenge ROS and provides valuable insights into the underlying mechanism, demonstrating the potential therapeutic effects of nanozyme for the prevention and treatment of NLRP3‐associatied inflammatory diseases.
Highly Enhanced Polarization Switching Speed in HfO2‐based Ferroelectric Thin Films via a Composition Gradient Strategy
Authors: Hao Puqi , Zheng Shuaizhi , Zeng Binjian , Yu Tao , Yang Zhibin , Liao Luocheng , Peng Qiangxiang , Yang Qijun , Zhou Yichun , Liao Min 
Published: April 2023

AbstractThe next‐generation semiconductor memories are essentially required for the advancements in modern electronic devices. Ferroelectric memories by HfO2‐based ferroelectric thin films (FE‐HfO2) have opened promising directions in recent years. Nevertheless, improving the polarization switching speed of FE‐HfO2 remains a critical task. In this study, it is demonstrated that the composition‐graded Hf1‐xZrxO2 (HZO) ferroelectric thin film has more than two times faster polarization switching speed than the conventional composition‐uniform one. Meanwhile, it has excellent ferroelectricity and improved endurance characteristics. It is also discovered that when the HZO thin film has a gradient composition, the polarization‐switching dynamics shifts from the nucleation‐limited‐switching mechanism to the domain‐wall growth mechanism. Moreover, the transition of switching dynamics is responsible for the faster speed and better endurance of the composition‐graded HZO thin film. These findings not only reveal the physical mechanisms of this material system but also provide a new strategy for memory devices having faster speed and higher endurance.