bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Novel Strategy for Preparation of Solvent-Free High-Solid Content Water-Based Polyurethane
Authors: Fan Haojun , Yao Aisong , Li Heng , Luo Haihang , Zhao Jianming , Xiang Jun , Chen Yi 
Published: May 2023

AbstractEethylenediamine (EDA), isophorone diamine (IPDA), diethylenetriamine (DETA), N- β- (aminoethyl)- γ- aminopropylmethyl dimethoxysilane (KH602) and polyether amine (D-230) were used as post chain extenders, a series of solvent-free high-solid content water-based polyurethanes (WPU) were prepared. The reactivity of different post chain extenders and the effects of different R values (mole ratio of –NCO/-OH) on solid content as well as the effects of chain extension degree on properties of WPU were investigated in detail. Among of water, small molecule diamine and diol, diamine with higher activity is preferred to water to complete the post chain extension reaction and improves the mechanical properties of WPU. When the R value is higher than 1.7 and the post chain extension degree is controlled at 70%, the viscosity of the solvent-free prepolymer is small enough to be emulsified, and the as-prepared WPUs show more excellent thermodynamic properties. In comparison, the cyclic chain extender such as IPDA can improve the mechanical properties and heat resistance of WPU, crosslinking type chain extenders involving DETA and KH602 can improve the heat resistance and anti-sticking of WPU coating. Whilst the WPU prepared by the chain extender containing flexible space, such as D-230, has a very low modulus and is suitable for preparing soft–type WPU.
Electromagnetic field-assisted low-temperature ammonia synthesis
Authors: Zhang Bin , Zhang Bao Shun , Wang Yuting , Zhang Na , Zhu Jiewei , Ji Wangyang , Chen Fanpeng , Chen Xing , Yu Yifu 
Published: May 2023

AbstractConventional ammonia synthesis (Haber-Bosch method) requires high temperature and high pressure, leading to extensive energy consumption and carbon emissions. Herein, an electromagnetic field (EMF)-assisted technique is developed for ammonia synthesis under mild conditions. With the assistance of EMF, commercial Fe-based catalysts exhibit obvious enhancement in ammonia yield (5 times) and energy efficiency (2.7 times) at 200°C and 1 MPa, originating from the effective activation of the N≡N bond.
Synthesis of allylamines from Baylis-Hillman acetates using DBU under solvent free condition
Authors: Khom Sonam Tashi , Saikia Pranjit , Muzaddadi Ijaz Ullah , Murugan Arumugam , Yadav Nagendra Nath Nath 
Published: May 2023

Abstract
A simple, new and solvent free route to the regioselective and stereoselective synthesis of (E)- and (Z)- allylamines has been achieved by the reaction of Baylis-Hillman acetates with various nitrogen nucleophiles in the presence of 1,8-diazabicyclo(5.4.0)undec-7-ene (DBU). This method requires very short reaction time and accomplished by SN2ʹ nucleophilic substitution pathway.
Orthodontic Patients and the Information Found on the Web: A Cross-sectional Study
Authors: Crispino Roberta , Mannocci Alice , Dilena Irene Alfonsa , Sides Jackson , Forchini Federico , Alherawi Wael Mohammad Asif , Frazier-Bowers Sylvia A. , Grippaudo Cristina 
Published: May 2023

Abstract
Background We sought to understand the relevance of online information for prospective orthodontic patients and to investigate the effects of digital research on patients’ decision-making process. We speculate that generational differences exist between digital natives and digital immigrants.Materials and methods An anonymous questionnaire was developed to investigate patients’ orthodontic-themed Web searches as well as the effects digital material had on their decision-making process. Before submitting the newly designed survey to patients, it was validated in a pilot study. Univariate analysis was applied to analyze the relationship between the demographic characteristics of respondents and their answers on the use of digital research for the decision-making process.Results 64.6% of the study population searched the Web for orthodontic information prior to their visit. Google was the most used platform regardless of patients’ age. The perceived reliability of online sources varied significantly with age. Men displayed more trusting behavior towards their doctor than women. Prospective patients’ satisfaction with affected patients’ decision-making processes, and the perceived reliability of online sources of information had repercussions on the doctor-patient relationship.Conclusions Orthodontists should be aware that the majority of patients use the Internet as a source for orthodontic information, and that patients who are digital immigrants are more prone to trust the information found online. Patients who perceive the information found on the Web as either useful or reliable don’t easily discard it, even if it is inconsistent with the orthodontist’s opinion.
Temperature extremes of 2022 reduced carbon uptake by forests in Europe
Authors: Peters Wouter , Woude Auke van der , Luijkx Ingrid , Joetzjer Emilie , Lafont Sébastien , Loubet Benjamin , Herig-Coimbra Pedro-Henrique , Loustau Denis , Koren Gerbrand , Ciais Philippe , Ramonet Michel , Xu Yidi , Bastos Ana , Sitch Stephen , Kneuer Tobias , Kubistin Dagmar , De Kok Remco , Botía Santiago 
Published: May 2023

Abstract
The year 2022 saw record breaking temperatures in Europe during both summer and fall. Close to 30% of the European continent was under severe summer drought with a similarly large area affected (3.0 million km2) as during the recent 2018 drought, but now located in central and southeastern Europe. Multiple sets of observations suggest a reduction of net ecosystem carbon exchange in summer (57-62 TgC) over this area, and specific sites in France even showed a widespread summertime carbon release by forests, as well as wildfires. A warm fall with prolonged carbon uptake offered only partial compensation (up to 32%) for the carbon uptake lost due to drought. This severity of this second drought event in 5 years suggests these impacts to no longer be exceptional, and important to factor into Europe's developing plans for net-zero greenhouse gas emissions that rely on carbon sequestration by forests.
In vitro evaluation and characterization of cisplatin loaded nanofibers for local chemotherapy
Authors: Mendoza Carlos Miguel López , Figueroa Yolanda Terán , Sánchez Mariana Gutiérrez , Ortega María Mónica Castillo , Fuentes Nayeli Rodríguez , Alcántara Luz Eugenia 
Published: May 2023

Abstract

Cancer is a disease that affects the quality of life of the patients that are treated with Cisplatin (CDDP), which is needed for adjuvant therapy, however it leads to many secondary and adverse effects. In this study, we manufactured and characterized poly- (lactic acid) (PLA) non-woven fibers charged with Cisplatin (CDDP) by electrospinning technique to evaluate their cytotoxicity in in vitro assays on HeLa cells (Cervical Carcinoma Cell Line). PLA – CDDP solutions with increasing concentrations of CDDP (0.5, 1 and 2 % w/w) were used in a TL-01 electrospinning equipment with the same system parameters. We analyzed the chemical, thermal and morphological characteristics of PLA and PLA – CDDP fiber mats. Furthermore, hydrolytic degradation, haemolysis and toxicity in HeLa cells were evaluated. By adding the CDDP to the fibers, the degradation, glass transition and melting temperatures were modified; the 3 µm fiber diameter of pristine PLA fibers was decreased in half the size and the degradation time was extended over 5 months. However, the hemocompatibility of the material with and without CDDP was mantained, while cytotoxicity in HeLa cells increased in the three concentrations of fiber mats of PLA – CDDP compared to the intravenous drug at 24 h (P = ). We concluded that the fiber mats PLA – CDDP could be used for localized treatment in the adjuvant treatment when resection panels are expose after a surgical extirpation of solid tumors
Glutamate production from aerial nitrogen using nitrogen-fixing bacterium Klebsiella oxytoca
Authors: Nishiyama Makoto , Yoshidome Daisuke , Hidaka Makoto , Miyanaga Toka , Ito Yusuke , Kosono Saori 
Published: May 2023

Abstract
Glutamate is an essential biological compound produced for various practical uses. However, the current glutamate production process requires a large amount of ammonium produced through the most energy-consuming and CO2-emitting Haber–Bosch process; hence, the development of bioeconomical glutamate-producing processes has long been awaited. This study demonstrates a novel strategy for glutamate production from aerial nitrogen using the nitrogen-fixing bacterium Klebsiella oxytoca. Carbon sources were first investigated to enhance the nitrogenase activity of K. oxytoca, and it was found that the simultaneous supply of glucose and citrate was effective. K. oxytoca was genetically engineered to increase citrate uptake under glucose-citrate-coexisting conditions and the supply of 2-oxoglutarate, a direct precursor of glutamate synthesis. As a result, extracellular production of glutamate over 1 g L-1 of culture from aerial nitrogen was achieved. This strategy offers a sustainable and eco-friendly manufacturing process to produce various nitrogen-containing compounds using aerial nitrogen.
LncRNA THUMPD3-AS1 promotes invasion and EMT in gastric cancer by regulating the miR-1297/BCAT1 pathway
Authors: Zhang Zaibo , Li Yong , Fan Liqiao , Wang Bingyu , Liu Wenbo , Cui Jiaxiang , Tan Bibo 
Published: May 2023

Abstract
Objective Long noncoding RNAs (lncRNAs) are significant regulators in gastric cancer（GC）; However, studies of their mechanisms of action are needed to determine their clinical value. In this study, we investigated the effects and mechanism of action of THUMPD3-AS1 in GC.
Methods Candidate lncRNAs and mRNAs were getted from The Cancer Genome Atlas, revealing the differential expression and prognostic significance of THUMPD3-AS1-BCAT1 in GC. qRT-PCR was performed to detect THUMPD3-AS1 levels in GC samples and cell lines. CCK8, scratch wound healing, and Transwell assays as well as experiments in vivo were conducted to evaluate the function of THUMPD3-AS1 in GC. Related genes were analysed to detect interactions between THUMPD3-AS1, BCAT1, and miR-1297.
Results THUMPD3-AS1 levels were significantly elevated in GC and were positively correlated with poor prognosis. Functionally, THUMPD3-AS1 promoted GC cell proliferation, migration, invasion, and epithelial–mesenchymal transition (EMT) and induced tumour growth in vivo. THUMPD3-AS1 regulated BCAT1 by competitively binding to miR-1297; further analyses revealed that both THUMPD3-AS1 and miR-1297 can interact with BCAT1.
Conclusions These findings demonstrate that THUMPD3-AS1 promotes GC cell invasion and EMT via the miR-1297/BCAT1 pathway, suggesting that THUMPD3-AS1 is a novel biomarker and therapeutic target for GC.
Yielding and post-yielding behavior of FDM parts under compression stress
Authors: Scipioni Silvia Ilaria , Lambiase Francesco 
Published: May 2023

Abstract
The present study investigates the compression behavior of components made by material extrusion, also known as fused filament fabrication (FFF) or fused deposition modeling (FDM). An experimental plan was conducted by adopting a high-density fulfillment and varying the material flow. Additional tests were performed by thermomechanical compaction to produce full-density samples. Compression tests were performed at various strain rates ranging between 5 10− 4 to 5 10− 1 s− 1. Yielding and post-yielding behaviors were analyzed. Morphological analysis was carried out to determine the mesostructural features (interlayer neck and void sizes) and how they behave during the compression test. The results indicated that the principal dimension of the voids ranged between 65 µm and 170 µm depending on the adopted value of the extrusion multiplier. On the other hand, thermomechanical compaction enabled the restriction of the voids of printed samples to 10 µm. The cross-sectioning of samples at different strains indicated the formation of shear banding strain localization. In addition, printed samples behaved like porous media during the compression tests and showed different characteristic regions with different voids dimensions. The samples printed at the higher material extrusion showed similar behavior to compacted samples. Post-yielding analysis indicated that strain softening observed on compacted samples was more severe as compared to that observed on printed samples. this behavior is dramatically reduced by decreasing the extrusion multiplier.
AI based Recommendation System for smart investment decisions to maximize Fuzzy ROI
Authors: D Maria Manuel Vianny , Vaddadi Srinivas Aditya , C Karthikeyan , Shahid Mohammad , Dhanapal R. , M Ravichand 
Published: May 2023

Abstract
In the current training, Artificial Neural Network (ANN) is utilized, which tuned by Particle Swarm Optimization (PSO) to the challenge of predicting for finance applications. Several researches have shown that ANN-based strategies are trustworthy ways to estimate LSM. Most ANN training methods, however, struggle with serious issues including poor learning rates and getting stuck in indigenous smallest amount. Optimization algorithms (OA) like PSO container increase ANN presentation. PSO prototypical applications to ANN exercise not engaged in success planning to determine network design or relevant elements. Thus, the current work concentrated scheduled the request of a mixture ANN prototypical to the forecast based on fuzzy. For the ANN and PSO-ANN network models, a huge amount of statistics (a record with 168970 preparation records and 42243 challenging records) was collected after the Finance application. This data was used to make exercise and challenging datasets. All of the PSO algorithm variables (including the system limitation and system loads) remained tuned to provide maximized ROI. The projected outcomes (e.g., from ANN, PSO-ANN) aimed at together records (e.g., training and testing) of the models were calculated by one numerical catalogs, namely, Root-Mean-Squared Error (RMSE). As a consequence, together replicas displayed worthy presentation; nevertheless, the hybrid ANN model might outperform ANN in terms of performance, as determined by the ranking mechanism that was created. For the ANN and hybrid ANN replicas, it container be derived that the PSO-ANN prototypical demonstrated more dependability in predicting compared to the ANN.
Haploidentical transplant with posttransplant cyclophosphamide vs matched related and unrelated donor transplant in acute myeloid leukemia and myelodysplastic neoplasm
Authors: Rieger Max , Stolz Sebastian , Müller Antonia , schwotzer rahel , Nair Gayathri , Schneidawind Dominik , Manz Markus , Schanz Urs 
Published: May 2023

Abstract
Hematopoietic cell transplantation from haploidentical donors (haploHCT) has facilitated treatment of AML and MDS by increasing donor availability and became more feasible since the introduction of post-transplant cyclophosphamide (ptCY). In our single-center retrospective analysis including 213 patients with AML or MDS, we compare the outcome of haploHCT (n=40) with ptCY with HCT from HLA-identical MRD (n=105) and MUD (n=68). At 2 years after transplantation, overall survival (OS) after haploHCT was not significantly different (0.59; 95% confidence interval 0.44 - 0.79) compared to MRD (0.77; 0.67 - 0.88) and MUD transplantation (0.72; 0.64 - 0.82, p = 0.51). While progression-free survival (PFS) was also not significantly different (haploHCT: 0.60; 0.46 - 0.78, MRD: 0.55; 0.44 - 0.69, MUD: 0.64; 0.55 - 0.74, p = 0.64), non-relapse mortality (NRM) was significantly higher after haploHCT (0.18; 0.08 - 0.33) vs. MRD (0.029; 0.005 - 0.09) and MUD (0.06; 0.02 - 0.12, p<0.05). Higher NRM was mainly caused by a higher rate of fatal infections, while deaths related to GvHD or other non-relapse reasons were rare in all groups. As most fatal infections occurred early and were bacterial related, one potential risk factor among many was identified in the significantly longer time to neutrophil engraftment after haploHCT with a median of 16 days (interquartile range; 14.8 - 20.0) vs. 12 days (10.0 - 13.0) for MRD and 11 days (10.0 - 13.0) for MUD (p=0.01).
Solid-To-Solid Polymorphic Phase Transitions in Two Isostructural Bi(III) Complexes With 1-Phenylethyl-N-Ethylthiosemicarbazide and Halogens
Authors: Grześkiewicz Anita M. , Dutkiewicz Grzegorz , Aygun Ozlem , Ozturk Ibrahim I. , Kubicki Maciej 
Published: May 2023

Abstract
Two isostructural (in room temperature) complexes of Bi(III) with halogens and sulfur ligands have been investigated in terms of the solid-to-solid phase transitions indicated by temperature. Both chloride and bromide (X) complexes of the general formula (µ2-X)-(BiX2L2)2 exhibit some phase transitions between 100 and 333 K, which, apart from the numerous similarities, show significant differences, which have been noted and analyzed in detail in this paper by using different techniques, i.a., powder and single crystal diffraction or DSC. The obtained results have also been collated with those obtained for solid solutions of both complexes.
Three-dimensional CT imaging in extensor tendons using deep learning reconstruction: Optimal dose and reconstruction parameters
Authors: Tsuboi Kunihito , Kanbe Takamasa , Matsushima Hiroshi , Ohtani Yuki , Tanikawa Ken , Kaneko Masanori 
Published: May 2023

Abstract
The purpose of this study was to evaluate the optimal tube current and reconstruction parameters in extensor tendons 3-dimensional computed tomography (3D CT) using deep learning reconstruction, using iterative reconstruction as a reference. In phantom study, a cylindrical phantom with a 3 mm rod simulated an extensor tendon was used. The phantom images were scanned at tube current of 50, 100, 150, 200, and 250 mA. In the clinical study, nine hands in eight patients underwent CT of hand tendons. All images were reconstructed using advanced intelligent clear-IQ engine (AiCE) parameters (body, body sharp, brain CTA, and brain LCD) and adaptive iterative dose reduction three dimensional (AIDR 3D). Objective image quality for detectability of tendons was evaluated by calculated the low-contrast object specific contrast-to-noise ratio (CNRLO) in our phantom study and CNR and coefficient of variation (CV) in the clinical study, respectively. In phantom study, CNRLO (200 mA) of AiCE parameters (body, body sharp, brain CTA, and brain LCD) and AIDR 3D were 5.2, 5.3, 5.3, 5.8, and 5.0, respectively. In the clinical study, AiCE brain CTA was higher CNR and lower CV values than other reconstruction parameters. AiCE without dose reduction may be a useful strategy to further improve image quality of extensor tendons 3D CT. Our study suggests that the AiCE brain CTA is more suitable for extensor tendons 3D CT than other AiCE parameters.
Experimental study of in-medium spectral change of vector mesons at J-PARC
Authors: Aoki Kazuya , Arimizu Daichi , Ashikaga Sakiko , Chang Wen-Chen , Chujo Tatsuya , Ebata Kengo , En'yo Hideto , Esumi Shinichi , Hamagaki Hideki , Honda Ryotaro , Ichikawa Masaya , Kajikawa Shunsuke , Kanno Koki , Kimura Yuta , Kiyomichi Akio , Kondo Takehito , Kyan Shono , Lin Che-Sheng , Lin Chih-Hsun , Morino Yuhei , Murakami Hikari , Murakami Tomoki , Muto Ryotaro , Nagafusa Shunnosuke , Nakai Wataru , Nakasuga Satomi , Naruki Megumi , Nonaka Toshihiro , Noumi Hiroyuki , Ochiai Shuta , Ozawa Kyoichiro , Sakaguchi Takao , Sako Hiroyuki , Sakuma Fuminori , Sato Susumu , Sawada Shinya , Sekimoto Michiko , Shigaki Kenta , Shirotori Kotaro , Sugimura Hitoshi , Takahashi Tomonori , Takaura Yudai , Tatsumi Ryohei , Tsukui Kosuke , Wang Po-Hung , Yahiro Kanta , Yamaguchi Kanako , Yokkaichi Satoshi 
Published: May 2023

Abstract
Chiral symmetry and its spontaneous breaking is an essential property of the QCD vacuum and is closely related to the generation of hadron mass. J-PARC E16 experiment measures dielectron spectra in p+A collisions at 30~GeV to study the in-medium spectral change of vector mesons that signals the partial restoration of the broken symmetry. The experiment uses the primary proton beam available at the high-momentum beam line of the J-PARC hadron experimental facility.We performed three proton-beam runs intended for beamline and detector commissioning. We are preparing for the next commissioning run in 2023 and the first physics run. We present the experimental setup, some of the expected results, preparation status, and some findings in the commissioning runs.
Lie symmetry analysis, exact solutions and conservation laws to multi-component nonlinear Schrodinger equations
Authors: Bai Yushan , Liu Ya-Na , Ma Wen-Xiu 
Published: May 2023

Abstract
In this paper, the Lie symmetry group method is used to study the multi-component nonlinear Schr\"{o}dinger (MNLS) equations in nonlinear mathematical physics. The Lie point symmetries of MNLS equations are obtained. By applying the obtained symmetries, the symmetry reductions and some explicit solutions to the MNLS equations are constructed. In addition, we also find the conservation laws of the MNLS equations using Ibragimov's method.
Identification of m6A- and ferroptosis-related lncRNA signature for predicting immune efficacy in thymoma
Authors: Fang Hao , Li Runze , Sun Xinti 
Published: May 2023

Abstract
BACKGROUND: N6-methyladenosine (m6A) methylation and ferroptosis assist long non-coding RNAs (lncRNAs) to promote immune escape in thymoma (THYM). However, the predictive power of m6A and ferroptosis-associated lncRNAs in immune potency remains unknown.
METHODS: A total of 120 THYM samples with complete data were obtained from The Cancer Genome Atlas (TCGA) database as the training cohort, and half of them were randomly composed as the validation cohort, and various methods such as regression analysis and enrichment analysis were applied to screen, evaluate, etc.
RESULTS: We constructed prognosis-associated mfrlncRNA pairs after screening for lncRNAs associated with m6A regulators and ferroptosis-associated genes. According to this, the mfrlncRNA signature was founded utilizing least absolute shrinkage and selection operator (LASSO) analysis and Cox regression. We found that patients' risk score was an independent risk factor and was much better than clinical stage as an indicator. In addition, patients in the high-risk group had a poorer prognosis with higher B cells naive and Macrophages M0/M1/M2 infiltration, lower Plasma cells and T cells CD4 naive infiltration, higher immune escape potential (higher TIDE score) and higher IC50. Finally, mfrlncRNA signature contributes to risk prediction in THYM patients and prognostic improvement.
CONCLUSIONS: The mfrlncRNA signature has great prognostic value and may help to explore the relevant immune mechanisms in depth, with key implications for individualized treatment to improve the prognosis of THYM patients.