bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factors associated with weight gain during COVID-19 pandemic: A global study
Authors: Huang Junjie , Chan Sze Chai , Ko Samantha , Wang Harry H. X. , Yuan Jacky , Xu Wanghong , Zheng Zhi-Jie , Xue Hao , Zhang Lin , Jiang Johnny Y. , Huang Jason L. W. , Chen Ping , Palaganas Erlinda , Viwattanakulvanid Pramon , Somrongthong Ratana , Caicedo Andrés , Medina-Arellano María de Jesús , Murphy Jill , Paredes Maria B. A. , Withers Mellissa , Wong Martin C. S. ,   On behalf of the Association of Pacific Rim Universities (APRU) Global Health Program
Published: April 2023

Background
The coronavirus disease 2019 (COVID-19) pandemic has resulted in changes in lifestyle habits and experiences of mental health outcomes, some of which were possibly related to weight gain, leading to an increase in the prevalence of obesity, which is associated with the development of several severe diseases. Concerns regarding weight gain and its impact on health outcomes are prevalent worldwide, with obesity being one of the highest causes of mortality in current society.

Methods
A self-reported questionnaire collected data from participants aged 18 years of age and above from 26 countries and regions worldwide. Post-hoc multiple logistic regression analyses have been done to evaluate the association between demographic and socioeconomic factors, and the perspectives that were identified to be associated with weight gain.

Results
Participants belonging to a younger age group; with a higher level of education; living in an urban area; living with family members; employed full-time; and had obesity were found to be more vulnerable to weight gain. After adjusting for socio-demographic factors, participants who were quarantined; exercised less prior to the pandemic; consumed unhealthy foods; and reported negative thoughts such as helplessness and the perceived risk of COVID-19, were more likely to experience weight gain; while negative thoughts such as having no means of control over the COVID-19 pandemic and the consequences of the COVID-19 pandemic will have great personal effect were associated with females, students, and people living in the rural area.

Conclusions
Weight gain risk during the pandemic was significantly associated with certain socio-demographic and COVID-19 related factors. To improve public health outcomes, future research should conduct a longitudinal evaluation on the effects of COVID-19 experiences upon health choices. Streamlined mental support should also be provided to the vulnerable groups which were prone to negative thoughts that were associated with weight gain.
Ageing, functioning patterns and their environmental determinants in the spinal cord injury (SCI) population: A comparative analysis across eleven European countries implementing the International Spinal Cord Injury Community Survey
Authors: Sabariego Carla , Ehrmann Cristina , Bickenbach Jerome , Pacheco Barzallo Diana , Schedin Leiulfsrud Annelie , Strøm Vegard , Osterthun Rutger , Tederko Piotr , Seijas Vanessa , Eriks-Hoogland Inge , Le Fort Marc , Gonzalez Viejo Miguel A. , Bökel Andrea , Popa Daiana , Dionyssiotis Yannis , Baricich Alessio , Juocevicius Alvydas , Amico Paolo , Stucki Gerold 
Published: April 2023

BackgroundAs the European population with Spinal Cord Injury (SCI) is expected to become older, a better understanding of ageing with SCI using functioning, the health indicator used to model healthy ageing trajectories, is needed. We aimed to describe patterns of functioning in SCI by chronological age, age at injury and time since injury across eleven European countries using a common functioning metric, and to identify country-specific environmental determinants of functioning.MethodsData from 6’635 participants of the International Spinal Cord Injury Community Survey was used. The hierarchical version of Generalized Partial Credit Model, casted in a Bayesian framework, was used to create a common functioning metric and overall scores. For each country, linear regression was used to investigate associations between functioning, chronological age, age at SCI or time since injury for persons with para- and tetraplegia. Multiple linear regression and the proportional marginal variance decomposition technique were used to identify environmental determinants.ResultsIn countries with representative samples older chronological age was consistently associated with a decline in functioning for paraplegia but not for tetraplegia. Age at injury and functioning level were associated, but patterns differed across countries. An association between time since injury and functioning was not observed in most countries, neither for paraplegia nor for tetraplegia. Problems with the accessibility of homes of friends and relatives, access to public places and long-distance transportation were consistently key determinants of functioning.ConclusionsFunctioning is a key health indicator and the fundament of ageing research. Enhancing methods traditionally used to develop metrics with Bayesian approach, we were able to create a common metric of functioning with cardinal properties and to estimate overall scores comparable across countries. Focusing on functioning, our study complements epidemiological evidence on SCI-specific mortality and morbidity in Europe and identify initial targets for evidence-informed policy-making.
Systematic review on cost-effectiveness analysis of school-based oral health promotion program
Authors: Rochmah Thinni Nurul , Ramadhani Aulia , Bramantoro Taufan , Permata Lucindari Gea , Tun Tin Zar 
Published: April 2023

Objective
This study aims to assess the variance of the cost-effectiveness ratio of the school-based oral health promotion and prevention program for elementary school children.

Methods
This review protocol was registered in the international database of Prospectively Registered Systematic Reviews in Health and Social Care (PROSPERO) (No: CRD 42022326734). The search for articles conducted in March-April 2022 focuses on any kind of school-based Promotive and Preventive Program for elementary school children that have control groups, and the outcome was Incremental Cost-Effectiveness Ratio (ICER). Grey literatures are not eligible. This review used five databases (PubMed, Scopus, Web of Science, CINAHL, and Google Scholar). Two independent reviewers referred to the PICO for inclusion and exclusion criteria and carried out the systematic review process. JBI ACTUARI Guidance for Critical Appraisal of Economic Evaluation Assessment Tools was used to assess the quality of the study.

Results
Of the total 1,473 articles found, there were 5 articles that matched the article search criteria and were included in a systematic review. It was known that the labor cost has a large proportion of the total program cost, and cost-saving programs were found in the two milk fluoridation programs (18.59 USD and 1.7 USD/averted DMF-S), fluoride mouth rinsing program (10.86 USD), and a comprehensive program with glass ionomer cement (461,766.37 USD/averted DALYs).

Conclusion
The fluoride programs and the comprehensive program with glass ionomer cement have the lowest cost-effectiveness ratio.
GlassDB: An Efficient Verifiable Ledger Database System Through Transparency
Authors: Yue Cong , Dinh Tien Tuan Anh , Xie Zhongle , Zhang Meihui , Chen Gang , Ooi Beng Chin , Xiao Xiaokui 
Published: April 2023

Verifiable ledger databases protect data history against malicious tampering. Existing systems, such as blockchains and certificate transparency, are based on transparency logs --- a simple abstraction allowing users to verify that a log maintained by an untrusted server is append-only. They expose a simple key-value interface without transactions. Building a practical database from transparency logs, on the other hand, remains a challenge.In this paper, we explore the design space of verifiable ledger databases along three dimensions: abstraction, threat model, and performance. We survey existing systems and identify their two limitations, namely, the lack of transaction support and the inferior efficiency. We then present GlassDB, a distributed database system that addresses these limitations under a practical threat model. GlassDB inherits the verifiability of transparency logs, but supports transactions and offers high performance. It extends a ledgerlike key-value store with a data structure for efficient proofs, and adds a concurrency control mechanism for transactions. GlassDB batches independent operations from concurrent transactions when updating the core data structures. In addition, we design a new benchmark for evaluating verifiable ledger databases, by extending YCSB and TPC-C benchmarks. Using this benchmark, we compare GlassDB against four baselines: reimplemented versions of three verifiable databases, and a verifiable map backed by a transparency log. Experimental results demonstrate that GlassDB is an efficient, transactional, and verifiable ledger database system.
Oral administration of wild plant‐derived minerals and red ginseng ameliorates insulin resistance in fish through different pathways
Authors: Takase Kiyomi , Kakuta Izuru 
Published: April 2023

AbstractMany kinds of fish are characterized by a limited efficiency to use carbohydrates. For this reason, raw fish and mixed feed containing a lot of fish meal have been used as feed for fish farming. However, continuing to use high‐protein diets not only increases the cost of fish farming, but may also fuel animal protein shortages. Furthermore, carbohydrates are added to improve the texture of the feed and act as a binding agent and are usually contained at 20% in the feed. It makes sense, therefore, to find ways to make good use of carbohydrates rather than wasting them. The physiological mechanisms of glucose intolerance in fish are not yet well understood. Therefore, we investigated the glucose utilization of fish, omnivorous goldfish Carassius auratus and carnivorous rainbow trout Oncorhynchus mykiss. Furthermore, the effects of oral administration of wild plant‐derived minerals and red ginseng on the glucose utilization in these fish muscle cells were investigated. As a result, we found the following. (1) An extremely high insulin resistance in fish muscle and the symptom was more pronounced in carnivorous rainbow trout. (2) Administration of wild plant‐derived minerals promotes the translocation of the insulin‐responsive glucose transporter GLUT4 to the cell surface of white muscle via activation of the PI3 kinase axis, whereas administration of red ginseng not only promotes GLUT4 transfer and translocation to the cell surface of white muscle via AMPK activation as well as promoting glucose uptake into muscle cells via a pathway separate from the insulin signaling system. (3) In fish, at least goldfish and rainbow trout, both PI3K/Akt and AMPK signaling cascades exist to promote glucose uptake into muscle cells, as in mammals.
High sodium intake does not worsen low potassium‐induced kidney damage
Authors: Zhang Yahua , Arroyo Juan Pablo , Bock Fabian , Zhang Ming‐Zhi , Harris Raymond C. , Terker Andrew S. 
Published: April 2023

AbstractHigh sodium and low potassium intake have both been linked to poor cardiovascular health outcomes and increased mortality rates. A combination of the two is thought to be particularly detrimental. While mechanisms are multiple, the kidney is an important target of harmful effects and low potassium influences on both proximal and distal nephron segments are especially potent. We recently reported that a combined high sodium/low potassium diet causes kidney injury and that low potassium in isolation can have similar effects. However, how sodium intake alters this process is not well‐understood. Here we tested the hypothesis that a high sodium intake amplifies effects of low dietary potassium on kidney injury. We observed adding high sodium to low potassium caused an expected increase in blood pressure, but did not worsen markers of kidney injury, inflammation, and fibrosis. It also did not increase abundance or phosphorylation of the sodium chloride cotransporter or its regulatory kinases, SPAK and OxSR1, known renal targets of low potassium. Findings support the claim that dietary potassium deficiency, and not high sodium, is a dominant factor affecting kidney injury in animal models of high sodium/low potassium intake. This suggests further investigation is required to identify optimal ranges of sodium and potassium intake in both healthy populations and in those with kidney disease.
Multi-response Optimization by Using Taguchi Based Grey Relational Analysis to Develop Chafe Resistance Underwear
Authors: Jamshaid Hafsa , Ahmad Naseer , Khan Awais , Hussain Uzair 
Published: April 2023

Abstract
This paper presents a multi-response optimization technique to study the effect of linear density and fiber blend (%) on the chafe resistance of knitted fabric. As underwear fabrics come in direct contact with the skin, they demand better chafe resistance properties that depend on the frictional behavior of the garments. The objective of this study is to investigate the effect of different blends (%) of cotton, Coolmax, and micro polyester fibers, as well as two linear densities, i.e., 24/1s and 30/1s (Ne), on the friction and comfort properties of knitted underwear. The yarns’ frictional coefficient and tensile strength were tested. Thermo-physiological and tactile/hand properties of the knitted fabric were also investigated. It was concluded that both factors, blend % and yarn linear density, influenced fabric comfort properties. Combination of natural and synthetics fibers with finer linear density results in better-performing fabrics with regard to friction and moisture management. The statistical tool, analysis of variance, was used to evaluate the significance of the results. Grey relational analysis (GRA) was performed for the optimization of parameters and the sorting of the samples having the best-required properties. The sample containing 50 % cotton and 50 % micro polyester with a 30/1s yarn count was declared as the best sample based on the GRA.
Increased Network Inhibition in the Dentate Gyrus of Adult Neuroligin-4 Knock-Out Mice
Authors: Muellerleile Julia , Vnencak Matej , Sethi Mohammad Valeed Ahmed , Jungenitz Tassilo , Schwarzacher Stephan W. , Jedlicka Peter 
Published: April 2023

AbstractLoss-of-function mutations in neuroligin-4 (Nlgn4), a member of the neuroligin family of postsynaptic adhesion proteins, cause autism spectrum disorder in humans. Nlgn4 knockout (KO) in mice leads to social behavior deficits and complex alterations of synaptic inhibition or excitation, depending on the brain region. In the present work, we comprehensively analyzed synaptic function and plasticity at the cellular and network levels in hippocampal dentate gyrus of Nlgn4 KO mice. Compared with wild-type littermates, adult Nlgn4 KO mice exhibited increased paired-pulse inhibition of dentate granule cell population spikes, but no impairments in excitatory synaptic transmission or short-term and long-term plasticityin vivo.In vitropatch-clamp recordings in neonatal organotypic entorhino-hippocampal slice cultures from Nlgn4 KO and wild-type littermates revealed no significant differences in excitatory or inhibitory synaptic transmission, homeostatic synaptic plasticity, and passive electrotonic properties in dentate granule cells, suggesting that the increased inhibitionin vivois the result of altered network activity in the adult Nlgn4 KO. A comparison with prior studies on Nlgn 1–3 knock-out mice reveals that each of the four neuroligins exerts a characteristic effect on both intrinsic cellular and network activity in the dentate gyrusin vivo.
Coumestrol induces oxidative stress and impairs migration and embryonic growth
Authors: Marbrey Margeaux W , Douglas Elizabeth S , Goodwin Emma R , Caron Kathleen M 
Published: April 2023

In brief
Healthy development of the placenta is dependent on trophoblast cell migration and reduced oxidative stress presence. This article describes how a phytoestrogen found in spinach and soy causes impaired placental development during pregnancy.

Abstract
Although vegetarianism has grown in popularity, especially among pregnant women, the effects of phytoestrogens in placentation lack understanding. Factors such as cellular oxidative stress and hypoxia and external factors including cigarette smoke, phytoestrogens, and dietary supplements can regulate placental development. The isoflavone phytoestrogen coumestrol was identified in spinach and soy and was found to not cross the fetal–placental barrier. Since coumestrol could be a valuable supplement or potent toxin during pregnancy, we sought to examine its role in trophoblast cell function and placentation in murine pregnancy. After treating trophoblast cells (HTR8/SVneo) with coumestrol and performing an RNA microarray, we determined 3079 genes were significantly changed with the top differentially changed pathways related to the oxidative stress response, cell cycle regulation, cell migration, and angiogenesis. Upon treatment with coumestrol, trophoblast cells exhibited reduced migration and proliferation. Additionally, we observed increased reactive oxygen species accumulation with coumestrol administration. We then examined the role of coumestrol within an in vivo pregnancy by treating wildtype pregnant mice with coumestrol or vehicle from day 0 to 12.5 of gestation. Upon euthanasia, fetal and placental weights were significantly decreased in coumestrol-treated animals with the placenta exhibiting a proportional decrease with no obvious changes in morphology. Therefore, we conclude that coumestrol impairs trophoblast cell migration and proliferation, causes accumulation of reactive oxygen species, and reduces fetal and placental weights in murine pregnancy.
Aportaciones de la Lingüística de Corpus al estudio de la conferencia como género académico de divulgación científica / Corpus Linguistics contributions to the study of conference presentations as an academic discourse
Authors: Robles Garrote Pilar 
Published: April 2023

This article aims to present an overview of what the research landscape Corpus Linguistics has contributed to the study of conference presentation as an academic discourse to the dissemination of scientific knowledge. To this end, a brief review is done through various contributions from studies based on the analysis of corpus which in recent years have addressed the scientific conference presentation genre from different perspectives, outlining the empirical approach to this field of Linguistics.
La visión moral de Luis Buñuel en Nazarín: una emancipación de la novela galdosiana
Authors: Vázquez Couto David 
Published: April 2023

La versión cinematográfica de la novela galdosiana Nazarín, dirigida por Luis Buñuel, afronta la problemática de la adaptación como proceso de traducción de la obra. El trasvase del texto escrito al ámbito de la imagen trae consigo, además de la complejidad estructural inherente a cada medio, los elementos creativos del cineasta insertos en el relato. Las aportaciones de Luis Buñuel a la novela transforman el significado del mensaje y lo llevan hacia una nueva dimensión moral que emancipa al film del texto literario.Palabras clave: Luis Buñuel, Benito Pérez Galdós, cine, literatura, adaptación.The moral vision of Luis Buñuel in Nazarín: an emancipation of Galdosian novelAbstract: The film version of galdosian novel Nazarín, directed by Luis Buñuel, confronts the problem of adaptation as a translation of the work. The transfer of written text to the field of image brings with it, besides the structural complexity inherent in each medium, the creative elements of the filmmaker inserted in the story. Luis Buñuel’s contributions to the novel transform the meaning of the message and lead it to a new moral dimension that emancipates the film from the literary text.Key words: Luis Buñuel, Benito Pérez Galdós, cinema, literature, adaptation.
Lo excepcional en la excepción: la estela de la fábula animal en Mario Benedetti y Virgilio Piñera
Authors: Abellán Chuecos Isabel 
Published: April 2023

Si bien es sabido que la fábula originalmente no era solamente la de animales, es cierto que a través de las fábulas de La Fontaine la idea que ha ido adentrándose en la sociedad ha sido ésta. En este sentido, nos encontramos con dos autores que siguen esta estela aunque de manera puntual: Mario Benedetti y Virgilio Piñera. Sin embargo, aunque en estos casos la estela sea seguida de forma puntual, no por ello es menos excepcional. Nos encontramos con sendos cuentos que toman este modelo y se desmarcan en el corpus. Son dos muestras anómalas en la producción de los autores que no por ello tienen menos valor. Además, dan un giro a la fábula de animales aunque enraizándose con ella, lo cual presenta un punto de vista muy atractivo.Palabras clave: fábula clásica, fábula animal, recepción, Mario Benedetti, Virgilio Piñera.What’s exceptional in the exception: the trail of the animal fable in the works of Mario Benedetti and Virgilio PiñeraAbstract: It is a well known fact that originally fables were not only about animals, but also, through the fables of La Fontaine, this is the idea that has gone deep into society. In this sense, we find two authors who follow this trail in an unusual, although not exceptional, manner, Mario Benedetti and Virgilio Piñera. We find tales that adopt this model and, at the same time, are distanced in the corpus. There are two anomalous samples in the production of both authors that, despite that fact, aren’t less valuable. On one hand, both stories remain rooted in the tradition, and on the other, they give a twist to animal fables and this show a very attractive point of view.Key words: classic fable, animal fable, reception, Mario Benedetti, Virgilio Piñera.