bluuebunny/crossref_metadata_2025_split huggingface dataset:
Maternal mental health mediates the effect of prenatal stress on infant temperament: The Harvey Mom Study
Authors: Lipschutz Rebecca , Kulesz Paulina A. , Elgbeili Guillaume , Biekman Brian , Laplante David P. , Olson David M. , King Suzanne , Bick Johanna 
Published: April 2023

AbstractPrenatal maternal stress and mental health problems are known to increase risk for developmental psychopathology in offspring, yet pathways leading to risk or resiliency are poorly understood. In a quasi-experimental design, we prospectively examined associations between disaster-related prenatal stress, maternal mental health symptoms, and infant temperament outcomes. Mothers who were pregnant during Hurricane Harvey (N = 527) reported on objective hardships (e.g., loss of belongings or income, evacuation, home flooding) related to the storm and subsequent mental health symptoms (anxiety/depression, posttraumatic stress) across time. At a postpartum assessment, mothers reported on their infant’s temperament (negative affect, positive affect, orienting/regulatory capacity). Greater objective hardship indirectly predicted higher levels of infant orienting/regulatory capacity through its association with increased maternal posttraumatic stress symptoms. Greater objective hardship also indirectly predicted higher levels of infant negative affect through its association with increased maternal anxiety/depression symptoms across time. Our findings suggest a psychological mechanism linking prenatal stress with specific temperamental characteristics via maternal mental health symptoms. Findings point to the importance of high-quality assessment and mental health services for vulnerable women and young children.
A DAE perspective on the interface between adaptive and maladaptive personality development: A conceptual replication
Authors: Koster Nagila , Laceulle Odilia M. , Prinzie Peter , Van der Heijden Paul T. , Van Aken Marcel A.G. 
Published: April 2023

AbstractThis study aimed to examine Dispositional, Adaptational, and Environmental (DAE) variables at the intersection of adaptive and maladaptive personality development as a conceptual replication of the DAE-model (Asendorpf & Motti-Stefanidi, European Journal of Personality, 32(3), 167–185, 2018). In a community sample of adolescents (N = 463; Mage = 13.6 years; 51% female) hypotheses-driven cross-lagged panel models were tested. Longitudinal associations between Dispositional (i.e., neuroticism, disagreeableness and unconscientiousness), Adaptational (i.e., social problems), and Environmental (i.e., perceived quality of the parent-child relationship) variables were investigated. The results partially support the DAE hypotheses. High levels of neuroticism, disagreeableness and social problems were found to predict the perceived quality of the parent–child relationship. In turn, the perceived quality of the parent–child relationship was found to predict levels of unconscientiousness and social problems. No mediation effects were found and, in contrast to DAE hypotheses, results did not indicate bidirectional influences between dispositions and adaptations. The results shed light on differential person–environment interactions that shape personality development and the importance of the perceived quality of the parent–child relationship. These findings provide insight in pathways of personality development, that may lead to personality pathology, and demonstrate the value of the DAE model as a structured guideline that provides testable hypotheses.
The impact of discrimination and support on immigrant trust and belonging
Authors: Tyrberg Maria 
Published: April 2023

AbstractHow are immigrants’ feelings of inclusion and trust in political institutions affected by interactions with the host society? In a field dominated by observational correlation studies, I use a survey experiment in two national contexts to test how perceptions of discrimination and expressions of pro-immigrant support influence non-Western immigrants’ political trust and national belonging. Following standard experimental procedures to test the hypotheses, I attempt to prime perceptions of group discrimination by asking questions about unfair treatment. Expressions of pro-immigrant support are, in turn, primed with facts about public and institutional support for immigrants’ rights. The results from the survey experiment are in line with expectations from prior work in some subgroups and underline the importance of equal treatment to achieve social cohesion. They also paint a rather complex picture of discrimination and its psychological impact. These findings have substantial implications for our understanding of host societies’ roles in immigrant inclusion.
Adapted and unadapted texts: do any of us ever read just what our author wrote?
Authors: Moran Jerome 
Published: April 2023

AbstractWe do not possess, nor are we ever likely to possess, any autograph of a Greek or Latin literary text from antiquity. We do not always apprise our students of this fact. This article seeks to explain why we possess only copies of the texts, often adapted for one reason or another and at many stages removed from the autographs. It also explains why certain kinds of originals cannot by their nature be copied or adapted, and are lost to us as soon as they are created. Non-literary texts too, written on durable materials other than papyri and parchment, do not, for various reasons, always constitute autographs, or autographs that we and our students can have ready access to.
Projected Changes to Wintertime Air‐Sea Turbulent Heat Fluxes Over the Subpolar North Atlantic Ocean
Authors: Barrell Christopher , Renfrew Ian A. , King John C. , Abel Steven J. , Elvidge Andrew D. 
Published: April 2023

AbstractIn wintertime over the subpolar North Atlantic Ocean (SPNA), the strongest surface sensible and latent heat fluxes typically occur just downstream of the sea‐ice edge. The recent retreat in Arctic wintertime sea ice is changing the distribution of these turbulent heat fluxes, with consequences for the formation of the dense waters that feed into the Atlantic Meridional Overturning Circulation. Projections of turbulent heat flux over the SPNA are investigated using output from the HadGEM3‐GC3.1 climate model, produced as part of the sixth phase of the Coupled Model Inter‐Comparison Project. Comparison of two model resolutions (MM: 60 km atmosphere—1/4° ocean and HH: 25 km–1/12°) shows that the HH configuration more accurately simulates historic sea ice and turbulent heat flux distributions. The MM configuration tends to produce too much sea ice in the SPNA, affecting the turbulent heat flux distribution; however, it displays improved performance during winters with less sea ice, increasing confidence in future projections when less sea ice is predicted. Future projections are presented for low (SSP1‐2.6) and high (SSP5‐8.5) emissions pathways. The simulations agree in predicting that, with climate change, the SPNA will see reductions in wintertime sea ice and air‐sea turbulent fluxes later in the 21st century, particularly in the Labrador and Irminger Seas and the interior of the Nordic Seas, and a notable reduction in their decadal variability. These effects are more severe under the SSP5‐8.5 pathway. The implications for SPNA ocean circulation are discussed.
Evidence of Fluid Induced Earthquake Swarms From High Resolution Earthquake Relocation in the Main Ethiopian Rift
Authors: Raggiunti Martina , Keir Derek , Pagli Carolina , Lavayssière Aude 
Published: April 2023

AbstractFluid overpressure and fluid migration are known to be able to trigger or induce fault slip. However, relatively little is known about the role of fluids on generating earthquakes in some of the major continental rifts. To address this, we investigate the interaction between fluids and faults in the Main Ethiopian Rift (MER) using a large seismicity catalog that covers both the rift axis and rift margin. We performed cross‐correlation analysis on four major earthquake clusters (three within the rift and one on the rift margin) in order to significantly improve accuracy of the earthquake relative relocations and to quantify families of earthquakes in which waveforms are similar. We also analyzed variation of seismicity rate and seismic moment release through time for the four clusters. The major results are that for all four clusters the earthquake relocations are 5–15 km deep, aligned to clear N‐NNE striking, steeply (>60°) dipping planes. For the three clusters within the rift, the cross‐correlation analysis identifies earthquake families that occur in short swarms during which seismic rate and moment release increases. Together, this space and time pattern of the seismicity strongly points toward them being fluid induced, with fluid likely sourced from depth such as mantle derived CO2. In contrast, the seismicity on the rift margin lacks earthquake families, with occurrence of earthquakes more continuous in nature, which we interpret as pointing toward tectonic stress‐driven microseismic creep. Overall, our results suggest that deep sourced fluid migration within the rift is an important driver of earthquake activity.
Tracing Oceanic Sources of Heat Content Available for Atlantic Hurricanes
Authors: Harris E. A. , Marsh R. , Grist J. P. 
Published: April 2023

AbstractIn the Main Development Region (MDR) for Atlantic hurricanes, the volume of water warmer than 26.5°C quantifies the potential source of energy for major storms. Taking a Lagrangian perspective, this warm water is backtracked on seasonal timescales in an eddy‐resolving ocean model hindcast spanning 1988–2010. Being confined near the surface and assuming a mixed layer depth of 50 m, net heat fluxes into or out of water parcels advected toward the MDR are inferred from along‐trajectory temperature tendencies. To first order, these heat fluxes match surface net heat fluxes during the months over which water advects into the region. Contributions to this warm water in the preceding 6 months include water resident in the MDR (20%–40%), arriving via the North Brazil Current (NBC, 5%–15%), or via Ekman drift across 10°S. In relative terms, decreased contributions from the NBC and Ekman drift and more in situ warming within the MDR lead to warmer, more active hurricane seasons.
Flow‐Topography Interaction Along the Spanish Slope in the Alboran Sea: Vorticity Generation and Connection to Interior Fronts
Authors: Capó Esther , McWilliams James C. , Jagannathan Arjun 
Published: April 2023

AbstractFlow‐topography interaction is examined using a realistic simulation at submesoscale resolution. The study focuses on a strong, eastward fresh current flowing along the Spanish margin in the Alboran Sea. The current develops large cyclonic vertical vorticity over the irregular slope and separates downstream at a headland; vertical vorticity is advected offshore and an interior density front is sustained by the presence of denser waters to the east. Using a depth‐integrated vorticity balance formulation, we evince the major role of bottom stress as a vorticity generation mechanism, in the form of a bottom stress divergence torque. Our proposed formulation provides an alternative to the classic transport curl balance for quantifying vorticity budgets around the oceans, using high resolution models with well resolved bottom boundary layers. Also as a result of topographic interaction, we show that the fronts observed in the basin interior could be originated along the margins prior to current separation. This is manifested by large values of the Lagrangian frontogenetic tendency for buoyancy gradients, spanning the vertical extent of the boundary current and extending toward the interior.
Relationships Between foF2 and Various Solar Activity Proxies
Authors: Laštovička Jan , Burešová Dalia 
Published: April 2023

AbstractTo study ionospheric climate, to model the ionosphere (e.g., the International Reference Ionosphere—IRI) and to investigate its long‐term changes and trends, solar activity proxies/indices have been used, because long and homogeneous data series of solar ionizing flux are not available. To identify the optimum solar activity proxies, we use yearly average foF2 data of 11 ionospheric stations from middle and low/equatorial latitudes of four continents over 1976–2014 and six solar activity proxies, F10.7, sunspot numbers, F30, Mg II, He II, and solar H Lyman‐α flux. Mg II and F30 are found to be the best solar proxies for variability of foF2 at middle latitudes, not the usually used F10.7 or sunspot numbers. At equatorial latitudes the situation seems to be different with likely He II as the optimum solar proxy but all low/equatorial results are very preliminary. Solar activity describes 99% of the total variance of yearly foF2 and the foF2 dependence on solar proxies is highly linear at middle latitudes. The dependence of foF2 on F10.7 and sunspot numbers is significantly steeper in 1996–2014 than in 1976–1995, whereas for F30 both intervals provide the same dependence. We recommend for investigating the midlatitude yearly values of foF2 the solar proxy F30 followed by Mg II as the second one, not traditional F10.7 or sunspot numbers.
De-ubiquitination of SAMHD1 by USP7 promotes DNA damage repair to overcome oncogenic stress and affect chemotherapy sensitivity
Authors: Liu Jingwei , Zhou Tingting , Dong Xiang , Guo Qiqiang , Zheng Lixia , Wang Xiaoxun , Zhang Naijin , Li Danni , Ren Ling , Yi Fei , Zhang Ying , Li Ziwei , Wang Xiwen , Deng Chengsi , Li Chunlu , Xu Hongde , Guan Yi , Li Xiaoman , Yu Yang , Guo Wendong , Wang Zhuo , Jiang Bo , Wu Xuan , Bai Ning , Feng Yanling , Ma Mengtao , Kong Qingquan , Wei Jiayi , Wang Zhenshuang , Li Hao , Lu Songming , Cao Liangzi , Xiao Yutong , Song Xiaoyu , Wang Zhenning , Xing Chengzhong , Cao Liu 
Published: April 2023

AbstractOncogenic stress induces DNA damage repair (DDR) that permits escape from mitotic catastrophe and allows early precursor lesions during the evolution of cancer. SAMHD1, a dNTPase protecting cells from viral infections, has been recently found to participate in DNA damage repair process. However, its role in tumorigenesis remains largely unknown. Here, we show that SAMHD1 is up-regulated in early-stage human carcinoma tissues and cell lines under oxidative stress or genotoxic insults. We further demonstrate that de-ubiquitinating enzyme USP7 interacts with SAMHD1 and de-ubiquitinates it at lysine 421, thus stabilizing SAMHD1 protein expression for further interaction with CtIP for DDR, which promotes tumor cell survival under genotoxic stress. Furthermore, SAMHD1 levels positively correlates with USP7 in various human carcinomas, and is associated with an unfavorable survival outcome in patients who underwent chemotherapy. Moreover, USP7 inhibitor sensitizes tumor cells to chemotherapeutic agents by decreasing SAMHD1 in vitro and in vivo. These findings suggest that de-ubiquitination of SAMHD1 by USP7 promotes DDR to overcome oncogenic stress and affect chemotherapy sensitivity.
The National COVID Cancer Antibody Survey: a hyper-accelerated study proof of principle for cancer research
Authors: Fittall Matthew , Liu Justin , Platt James , Ionescu Maria , Sheehan Remarez , Johal Sukhmunni , Mew Rosie , Clark James , Watts Izzy , Tripathy Arvind , Little Martin , Patel Grisma , Panneerselvam Hari , Appanna Nathan , Burke Emma , McKenzie Hayley , Tilby Michael , Khan Sam , Lee Lennard Y. W. 
Published: April 2023

AbstractThe COVID-19 pandemic has led to a range of novel and adaptive research designs. In this perspective, we use our experience coordinating the National COVID Cancer Antibody Survey to demonstrate how a balance between speed and integrity can be achieved within a hyper-accelerated study design. Using the COVID-19 pandemic as an example, we show this approach is necessary in the face of uncertain and evolving situations wherein reliable information is needed in a timely fashion to guide policy. We identify streamlined participant involvement, healthcare systems integration, data architecture and real-world real-time analytics as key areas that differentiate this design from traditional cancer trials, and enable rapid results. Caution needs to be taken to avoid the exclusion of patient subgroups without digital access or literacy. We summarise the merits and defining features of hyper-accelerated cancer studies.
The TRAF2-p62 axis promotes proliferation and survival of liver cancer by activating mTORC1 pathway
Authors: Liang Xue , Yao Jiping , Cui Danrui , Zheng Weiyang , Liu Yanning , Lou Guohua , Ye Bingjue , Shui Liyan , Sun Yi , Zhao Yongchao , Zheng Min 
Published: April 2023

AbstractTRAF2 (Tumor necrosis factor receptor-associated factor 2) is a dual function protein, acting as an adaptor protein and a ubiquitin E3 ligase, which plays an essential role in mediating the TNFα-NFκB signal pathway. Dysregulated expression of TRAF2 has been reported in a variety of human cancers. Whether and how TRAF2 regulates the growth of liver cancer cells remains elusive. The goal of this study is to investigate potential dysregulation of TRAF2 and its biological function in liver cancer, and to elucidate the underlying mechanism, leading to validation of TRAF2 as an attractive liver cancer target. Here, we reported TRAF2 is up-regulated in human liver cancer cell lines and tissues, and high TRAF2 expression is associated with a poor prognosis of HCC patients. Proteomics profiling along with Co-immunoprecipitation analysis revealed that p62 is a new substrate of TRAF2, which is subjected to TRAF2-induced polyubiquitination via the K63 linkage at the K420 residue. A strong negative correlation was found between the protein levels of p62 and TRAF2 in human HCC samples. TRAF2 depletion inhibited growth and survival of liver cancer cells both in vitro and in vivo by causing p62 accumulation, which is partially rescued by simultaneous p62 knockdown. Mechanistically, TRAF2-mediated p62 polyubiquitylation activates the mTORC1 by forming the p62-mTORC1-Rag complex, which facilitates the lysosome localization of mTORC1. TRAF2 depletion inhibited mTORC1 activity through the disruption of interaction between p62 and the mTORC1 complex. In conclusion, our study provides the proof-of-concept evidence that TRAF2 is a valid target for liver cancer.
Dynamic and thermodynamic influences on precipitation in Northeast Mexico on orbital to millennial timescales
Authors: Wright Kevin T. , Johnson Kathleen R. , Marks Gabriela Serrato , McGee David , Bhattacharya Tripti , Goldsmith Gregory R. , Tabor Clay R. , Lacaille-Muzquiz Jean-Louis , Lum Gianna , Beramendi-Orosco Laura 
Published: April 2023

AbstractThe timing and mechanisms of past hydroclimate change in northeast Mexico are poorly constrained, limiting our ability to evaluate climate model performance. To address this, we present a multiproxy speleothem record of past hydroclimate variability spanning 62.5 to 5.1 ka from Tamaulipas, Mexico. Here we show a strong influence of Atlantic and Pacific sea surface temperatures on orbital and millennial scale precipitation changes in the region. Multiple proxies show no clear response to insolation forcing, but strong evidence for dry conditions during Heinrich Stadials. While these trends are consistent with other records from across Mesoamerica and the Caribbean, the relative importance of thermodynamic and dynamic controls in driving this response is debated. An isotope-enabled climate model shows that cool Atlantic SSTs and stronger easterlies drive a strong inter-basin sea surface temperature gradient and a southward shift in moisture convergence, causing drying in this region.
Characterization of a fold in TANGO1 evolved from SH3 domains for the export of bulky cargos
Authors: Arnolds Oliver , Stoll Raphael 
Published: April 2023

AbstractBulky cargos like procollagens, apolipoproteins, and mucins exceed the size of conventional COPII vesicles. During evolution a process emerged in metazoans, predominantly governed by the TANGO1 protein family, that organizes cargo at the exit sites of the endoplasmic reticulum and facilitates export by the formation of tunnel-like connections between the ER and Golgi. Hitherto, cargo-recognition appeared to be mediated by an SH3-like domain. Based on structural and dynamic data as well as interaction studies from NMR spectroscopy and microscale thermophoresis presented here, we show that the luminal cargo-recognition domain of TANGO1 adopts a new functional fold for which we suggest the term MOTH (MIA, Otoraplin, TALI/TANGO1 homology) domain. These MOTH domains, as well as an evolutionary intermediate found in invertebrates, constitute a distinct domain family that emerged from SH3 domains and acquired the ability to bind collagen.
Human CEACAM1 is targeted by a Streptococcus pyogenes adhesin implicated in puerperal sepsis pathogenesis
Authors: Catton Erin A. , Bonsor Daniel A. , Herrera Carolina , Stålhammar-Carlemalm Margaretha , Lyndin Mykola , Turner Claire E. , Soden Jo , van Strijp Jos A. G. , Singer Bernhard B. , van Sorge Nina M. , Lindahl Gunnar , McCarthy Alex J. 
Published: April 2023

AbstractLife-threatening bacterial infections in women after childbirth, known as puerperal sepsis, resulted in classical epidemics and remain a global health problem. While outbreaks of puerperal sepsis have been ascribed to Streptococcus pyogenes, little is known about disease mechanisms. Here, we show that the bacterial R28 protein, which is epidemiologically associated with outbreaks of puerperal sepsis, specifically targets the human receptor CEACAM1. This interaction triggers events that would favor the development of puerperal sepsis, including adhesion to cervical cells, suppression of epithelial wound repair and subversion of innate immune responses. High-resolution structural analysis showed that an R28 domain with IgI3-like fold binds to the N-terminal domain of CEACAM1. Together, these findings demonstrate that a single adhesin-receptor interaction can drive the pathogenesis of bacterial sepsis and provide molecular insights into the pathogenesis of one of the most important infectious diseases in medical history.
CAR-neutrophil mediated delivery of tumor-microenvironment responsive nanodrugs for glioblastoma chemo-immunotherapy
Authors: Chang Yun , Cai Xuechao , Syahirah Ramizah , Yao Yuxing , Xu Yang , Jin Gyuhyung , Bhute Vijesh J. , Torregrosa-Allen Sandra , Elzey Bennett D. , Won You-Yeon , Deng Qing , Lian Xiaojun Lance , Wang Xiaoguang , Eniola-Adefeso Omolola , Bao Xiaoping 
Published: April 2023

AbstractGlioblastoma (GBM) is one of the most aggressive and lethal solid tumors in human. While efficacious therapeutics, such as emerging chimeric antigen receptor (CAR)-T cells and chemotherapeutics, have been developed to treat various cancers, their effectiveness in GBM treatment has been hindered largely by the blood-brain barrier and blood-brain-tumor barriers. Human neutrophils effectively cross physiological barriers and display effector immunity against pathogens but the short lifespan and resistance to genome editing of primary neutrophils have limited their broad application in immunotherapy. Here we genetically engineer human pluripotent stem cells with CRISPR/Cas9-mediated gene knock-in to express various anti-GBM CAR constructs with T-specific CD3ζ or neutrophil-specific γ-signaling domains. CAR-neutrophils with the best anti-tumor activity are produced to specifically and noninvasively deliver and release tumor microenvironment-responsive nanodrugs to target GBM without the need to induce additional inflammation at the tumor sites. This combinatory chemo-immunotherapy exhibits superior and specific anti-GBM activities, reduces off-target drug delivery and prolongs lifespan in female tumor-bearing mice. Together, this biomimetic CAR-neutrophil drug delivery system is a safe, potent and versatile platform for treating GBM and possibly other devastating diseases.