bluuebunny/crossref_metadata_2025_split huggingface dataset:
Robust Self-Tuning Control under Probabilistic Uncertainty using Generalized Polynomial Chaos Models
Authors: Du Yuncheng , Budman Hector , Duever Thomas 
Published: July 2023

<p>A robust self-tuning controller for a chemical process is developed based on a generalized Polynomial Chaos (gPC) model that accounts for probabilistic time-invariant uncertainty. Using this model, it is possible to calculate analytical expressions of the one-step ahead predicted mean and variances of controlled and manipulated variables. The key idea is to consider these predicted values for performing online robust tuning of the controller through a quadratic optimization procedure. The gPC model is also used to identify overlap between consecutive probability density functions (PDFs) of manipulated variables and to find trade-offs between the aggressiveness of the self-tuning controller and robustness to uncertainty based on this overlap. The proposed methodology is illustrated by a continuous stirred tank reactor (CSTR) system with stochastic variations in the inlet concentration. The efficiency of the proposed algorithm is quantified in terms of control performance and robustness.</p>
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Impacts on quality: Enjoyment factors in blind and low vision audience entertainment ratings: A qualitative study
Authors: Naraine Mala D. , Fels Deborah 
Published: July 2023

<p>Audio description (AD) is one of the main methods that people who are blind or low vision (B/LV) use to access film, television, and theatre content. AD is a second audio track inserted into the space(s) where speech is absent, which tends to be only a few seconds. Contained in that second track is an audio description of the important visual information contained within a specific scene. However, as there is insufficient time to describe all visual information, decisions about what is important to describe and how to present that information (style) to optimize a B/LV viewer’s entertainment experience are required. Most research to date has considered only short-term, single-episode experiences to gauge viewers’ reactions to the AD content. In addition, this research typically has used a monotone, single style of audio description, which is defined as “the conventional style” in this paper. We use an integrative style instead, that is defined as ‘AD designed to fit a specific show”, and differed between shows. We carried out a within-subjects longitudinal study with eight episodes of a dark comedy, using different description styles and describers in order to assess viewer engagement and preferences for AD describer style, language use, timing, and fit to the show. Twenty-four blind participants viewed and rated all eight episodes. Major findings included that most participants found the integrative style entertaining, a fit with the specific episodes, and enjoyable. Some participants, however, preferred the conventional style and struggled with the language and topic of a dark comedy and its associated descriptions.</p>
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Penerapan Metode Economic Order Quantity (EOQ) Untuk Pengendalian Persediaan Biji Kedelai di UMKM XYZ
Authors: Habibie Mohammad Wildan , Widyaningrum Dzakiyah 
Published: July 2023

UMKM XYZ merupakan usaha produksi tahu yang berdiri dari 2009. Jenis Tahu yang diproduksi pada UMKM XYZ yaitu tahu mentah yang dipasarkan disekitar lokasi produksi. UMKM XYZ ini memutuhkan biji kedelai sebanyak 250-300 kg untuk memproduksi tahu setiap hari yang menghasilkan 16 kotak tahu dengan isi setiap kotaknya 180 biji. Karena permintaan tahu yang fluktuatif UMKM sering kekurangan stok (stock out) biji kedelai dikarenakan pemesanan biji kedelai yang tidak terjadwal dan kuantitas pemesanan biji kedelai yang kurang tepat. Dari permasalahan yang dialami UMKM XYZ peneliti menggunakan metode EOQ untuk menentukan jadwal pemesanan dan kuantitas pemesanan biji kedelai yang tepat, serta untuk meminimalisir biaya penyimpanan dari bahan baku. Dari hasil penelitian diperoleh kuantitas order sebesar 1.104 kg dan didapatkan Safety Stock sebesar 2.388 kg dengan nilai Reorder Point 4.348 kg.
Assessing the usefulness of a newly proposed metabolic score for visceral fat in predicting future diabetes: results from the NAGALA cohort study
Authors: Yang Ruijuan , Kuang Maobin , Qiu Jiajun , Yu Changhui , Sheng Guotai , Zou Yang 
Published: July 2023

ObjectiveVisceral adipose tissue assessment holds significant importance in diabetes prevention. This study aimed to explore the association between the newly proposed Metabolic Score for Visceral Fat (METS-VF) and diabetes risk and to further assess the predictive power of the baseline METS-VF for the occurrence of diabetes in different future periods.MethodsThis longitudinal cohort study included 15,464 subjects who underwent health screenings. The METS-VF, calculated using the formula developed by Bello-Chavolla et al., served as a surrogate marker for visceral fat obesity. The primary outcome of interest was the occurrence of diabetes during the follow-up period. Established multivariate Cox regression models and restricted cubic spline (RCS) regression models to assess the association between METS-VF and diabetes risk and its shape. Receiver operating characteristic (ROC) curves were used to compare the predictive power of METS-VF with body mass index (BMI), waist circumference (WC), waist-to-height ratio (WHtR), and visceral adiposity index (VAI) for diabetes, and time-dependent ROC analysis was conducted to assess the predictive capability of METS-VF for the occurrence of diabetes in various future periods.ResultsDuring a maximum follow-up period of 13 years, with a mean of 6.13 years, we observed that the cumulative risk of developing diabetes increased with increasing METS-VF quintiles. Multivariable-adjusted Cox regression analysis showed that each unit increase in METS-VF would increase the risk of diabetes by 68% (HR 1.68, 95% CI 1.13, 2.50), and further RCS regression analysis revealed a possible non-linear association between METS-VF and diabetes risk (P for non-linearity=0.002). In addition, after comparison by ROC analysis, we found that METS-VF had significantly higher predictive power for diabetes than other general/visceral adiposity indicators, and in time-dependent ROC analysis, we further considered the time-dependence of diabetes status and METS-VF and found that METS-VF had the highest predictive value for predicting medium- and long-term (6-10 years) diabetes risk.ConclusionMETS-VF, a novel indicator for assessing visceral adiposity, showed a significantly positive correlation with diabetes risk. It proved to be a superior risk marker in predicting the future onset of diabetes compared to other general/visceral adiposity indicators, particularly in forecasting medium- and long-term diabetes risk.
Development of ground-level NO2 models in Vietnam using machine learning and satellite observations with ancillary data
Authors: Ngo Truong Xuan , Phan Hieu Dang Trung , Nguyen Thanh Thi Nhat 
Published: July 2023

In this study, the aim was to create daily ground-level NO2 maps for Vietnam spanning from 2019 to 2021. To achieve this, various machine learning models (including the Mixed Effect Model, Neural Network, and LightGBM) were utilized to process satellite NO2 tropospheric columns from Ozone Monitoring Instrument (OMI) and TROPOMI, as well as meteorological and land use maps and ground measurement NO2 data. The LightGBM model was found to be the most effective, producing results with a Pearson r of 0.77, RMSE of 7.93 μg/m³, and Mean Relative Error (MRE) of 42.6% compared to ground truth measurements. The annual average NO2 maps from 2019–2021 obtained by the LightGBM model for Vietnam were compared to a global product and ground stations, and it was found to have superior quality with Pearson r of 0.95, RMSE of 2.27 μg/m³, MRE of 9.79%, based on 81 samples.
Comparative study of ultrasonic-guided betamethasone local injection and extracorporeal shock wave therapy in post-stroke hemiplegic shoulder pain: a randomized clinical trial
Authors: Zhang Jingjing , Mao Huiwen , Gao Fang , Li Yan , Yang Yang 
Published: July 2023

ObjectiveThis study aimed to compare the efficacy and safety of ultrasound-guided local injection (UGLI) of betamethasone around the shoulder and extracorporeal shock wave therapy (ESWT) in patients with hemiplegic shoulder pain.MethodForty-two patients with hemiplegic shoulder pain were randomly divided into the UGLI group (N = 21) and the ESWT group (N = 21). In the UGLI group, betamethasone was injected at the pain point around the shoulder under ultrasonic localization. In the ESWT group, an extracorporeal shock wave was performed at the pain points around the shoulder for 20 min of time, once a week, for 4 consecutive weeks. Both groups received rehabilitation training. The visual analog scale (VAS) evaluation was performed at baseline, 1 h, 1 week, and 1 month after treatment. Furthermore, Neer shoulder joint function scores, upper limb Fugl–Meyer assessment (FMA), modified Barthel index (MBI), Hamilton Depression Scale (HAMD), the MOS-item short-form health survey (SF-36) scores, and serum expression level of cytokine were evaluated at baseline and 1 month after treatment.ResultsAfter 1-h treatment, the UGLI group showed a greater effect on the degree of pain than the ESWT group (P = 0.017). After 4 consecutive weeks of intervention, the UGLI group showed a significant improvement in the serum level of cytokine expression compared with the ESWT group (P &lt; 0.05). The range of motion (ROM) of the hemiplegic shoulder (P &lt; 0.05) has no difference between the two groups (P &gt; 0.05).ConclusionThe ultrasonic-guided betamethasone local injection and extracorporeal shock wave both can improve hemiplegic shoulder pain. However, the UGLI can induce a more cytokine expression level.
Blink-related EEG oscillations are neurophysiological indicators of subconcussive head impacts in female soccer players: a preliminary study
Authors: Sattari Sahar , Kenny Rebecca , Liu Careesa Chang , Hajra Sujoy Ghosh , Dumont Guy A. , Virji-Babul Naznin 
Published: July 2023

IntroductionRepetitive subconcussive head impacts can lead to subtle neural changes and functional consequences on brain health. However, the objective assessment of these changes remains limited. Resting state blink-related oscillations (BROs), recently discovered neurological responses following spontaneous blinking, are explored in this study to evaluate changes in BRO responses in subconcussive head impacts.MethodsWe collected 5-min resting-state electroencephalography (EEG) data from two cohorts of collegiate athletes who were engaged in contact sports (SC) or non-contact sports (HC). Video recordings of all on-field activities were conducted to determine the number of head impacts during games and practices in the SC group.ResultsIn both groups, we were able to detect a BRO response. Following one season of games and practice, we found a strong association between the number of head impacts sustained by the SC group and increases in delta and beta spectral power post-blink. There was also a significant difference between the two groups in the morphology of BRO responses, including decreased peak-to-peak amplitude of response over left parietal channels and differences in spectral power in delta and alpha frequency range post-blink.DiscussionOur preliminary results suggest that the BRO response may be a useful biomarker for detecting subtle neural changes resulting from repetitive head impacts. The clinical utility of this biomarker will need to be validated through further research with larger sample sizes, involving both male and female participants, using a longitudinal design.
Impact of music performance anxiety on cardiovascular blood pressure responses, autonomic tone and baroreceptor sensitivity to a western classical music piano-concert
Authors: Moreno-Gutiérrez Juan Ángel , de Rojas Leal Carmen , López-González Manuel Víctor , Chao-Écija Alvaro , Dawid-Milner Marc Stefan 
Published: July 2023

IntroductionMusic Performance Anxiety (MPA) is a prevalent condition among musicians that can manifest both psychologically and physiologically, leading to impaired musical performance. Physiologically, MPA is characterized by excessive muscular and/or autonomic tone. This study focuses on the cardiovascular blood pressure responses, autonomic tone and baroreceptor sensitivity changes that occur during musical performance due to MPA.MethodsSix professional pianists perform a piece for piano written only for the left hand by Alexander Scriabin. The following parameters have been studied during the performance: ECG, non-invasive beat to beat continuous arterial blood pressure and skin conductance. Sympathetic and parasympathetic autonomic flow was studied with Wigner-Ville analysis (W-V) from R-R ECG variability, and baroreceptor sensitivity with the Continuous Wavelet Transform (CWT).ResultsDuring the concert a significant increase of heart rate, systolic, mean and diastolic arterial pressure were observed. No significant differences were found in skin conductance. The W-V analysis, which studies frequency changes in the time domain, shows a significant increase of sympathetic flow and a decrease of parasympathetic flow during the concert which is associated with a significant decrease in sympathetic and vagal baroreceptor sensitivity.DiscussionThe study of cardiac variability using the Wigner-Ville analysis may be a suitable method to assess the autonomic response in the context of MPA, and could be used as biofeedback in personalized multimodal treatments.
Mechanism of action of icaritin on uterine corpus endometrial carcinoma based on network pharmacology and experimental evaluation
Authors: Jin Yan-Bin , Liang Xiao-Chen , Cai Jun-Hong , Wang Kang , Wang Chen-Yang , Wang Wen-Hua , Chen Xiu-Li , Bao Shan 
Published: July 2023

BackgroundUterine corpus endometrial carcinoma (UCEC) belongs to a group of epithelial malignant tumors. Icaritin is the main active compound of Epimedii Folium. Icaritin has been utilized to induce UCEC cells to death.MethodsWe wished to identify potential targets for icaritin in the treatment of UCEC, as well as to provide a groundwork for future studies into its pharmacologic mechanism of action. Network pharmacology was employed to conduct investigations on icaritin. Target proteins were chosen from the components of icaritin for UCEC treatment. A protein–protein interaction (PPI) network was established using overlapping genes. Analyses of enrichment of function and signaling pathways were undertaken using the Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) databases, respectively, to select “hub genes”. Finally, experiments were carried out to ascertain the effect of icaritin on endometrial cancer (HEC-1-A) cells.ResultsWe demonstrated that icaritin has bioactive components and putative targets that are therapeutically important. Icaritin treatment induced sustained activation of the phosphoinositide 3-kinase/protein kinase B (PI3K/Akt pathway) and inhibited growth of HEC-1-A cells.ConclusionOur data provide a rationale for preclinical and clinical evaluations of icaritin for UCEC therapy.
Social skills training using multiple humanoid robots for individuals with autism spectrum conditions
Authors: Takata Keiji , Yoshikawa Yuichiro , Muramatsu Taro , Matsumoto Yoshio , Ishiguro Hiroshi , Mimura Masaru , Kumazaki Hirokazu 
Published: July 2023

IntroductionSocial skills training (SST) is used to help individuals with autism spectrum conditions (ASC) better understand the perspectives of others and social interactions, develop empathy skills, and learn how to engage with others socially. However, many individuals with ASC cannot easily sustain high motivation and concentration during such an intervention when it is administered by humans. We developed a social skills training program using multiple humanoid robots (STUH), including an android robot, that aimed to enable individuals with ASC to become familiar with the perspectives of others and improve their sociability and empathy skills. The objective of the present study was to investigate the effectiveness of STUH for these individuals.MethodsIn STUH, we prepared 50 social exercises that consisted of conversations and behavioral interactions between an android robot and a simple humanoid robot. We prepared another humanoid robot that featured a cartoon-like and mechanical design, which played the role of host. In the first half-session of STUH, participants worked on the exercise from the perspective of an outsider. In the second half-session of STUH, they simulated experience by using robots as their avatars. The intervention associated with STUH was conducted for five days in total. We conducted an analysis of variance (ANOVA) featuring the intervention time point as the independent variable to examine changes in each score on the sociability index items.ResultsIn total, 14 individuals with ASC participated in the study. The results of multiple comparison tests using the Bonferroni method indicated that all sociability index items improved between preintervention and follow-up. Our program enabled the participants to become familiar with the perspectives of others and improve their sociability.DiscussionGiven the promising results of this study, future studies featuring long-term follow-up should be conducted to draw definitive conclusions about the efficacy of our training system.
Chronic conditions and multimorbidity among West African migrants in greater Barcelona, Spain
Authors: MacKinnon Marina J. , Picchio Camila A. , Nomah Daniel K. , Segura Ariadna Rando , Selm Lena van , Fernández Emma , Buti Maria , Lens Sabela , Forns Xavier , Rodriguez-Tajes Sergio , Pamplona Javier , Lopez Carmen , Rodriguez-Frías Francisco , Lazarus Jeffrey V. 
Published: July 2023

ObjectivesThis study aimed to report the prevalence and identify potential risk factors of chronic conditions among West African migrants living in the greater Barcelona area, Spain, and explore the relationship between years of residence in Spain and chronic disease burden.MethodsThis cross-sectional study included 436 adult African migrants who participated in a community-based hepatitis B virus (HBV) screening and vaccination program (HBV-COMSAVA) in the greater Barcelona area from 21 November 2020 to 22 January 2022. Data were analyzed using standard descriptive statistics and bivariable and multivariable logistic regression.ResultsHBV, non-communicable diseases (NCDs) and metabolic risk factors, and multimorbidity prevalence were 9.17, 20.87, and 4.13%, respectively. Being male or having been previously tested for HBV were associated with higher odds of HBV positivity. Associated risk factors for NCDs and metabolic risk factors included living in Spain for &gt;5 years, being female, and being aged ≥50 years.ConclusionThe high prevalence of chronic conditions in migrant populations supports a need for early detection strategies and tailored public health interventions that aim to reduce the disease burden imposed on migrants and on health systems in host countries.
Omega-3 intake is associated with liver disease protection
Authors: Vell Mara Sophie , Creasy Kate Townsend , Scorletti Eleonora , Seeling Katharina Sophie , Hehl Leonida , Rendel Miriam Daphne , Schneider Kai Markus , Schneider Carolin Victoria 
Published: July 2023

BackgroundNon-alcoholic fatty liver disease (NAFLD) and alcoholic liver disease are among the most common liver diseases worldwide, and there are currently no Food and Drug Administration (FDA)-approved treatments. Recent studies have focused on lifestyle changes to prevent and treat NAFLD. Omega-3 supplementation is associated with improved outcomes in patients with chronic liver disease. However, it is unclear whether Omega-3 supplementation can prevent the development of liver disease, particularly in individuals at an increased (genetic) risk.MethodsIn this UK Biobank cohort study, we established a multivariate cox proportional hazards model for the risk of incident liver disease during an 11 year follow up time. We adjusted the model for diabetes, prevalent cardiovascular disorders, socioeconomic status, diet, alcohol consumption, physical activity, medication intake (insulin, biguanides, statins and aspirin), and baseline characteristics.ResultsOmega-3 supplementation reduced the risk of incident liver disease (HR = 0.716; 95% CI: 0.639, 0.802; p = 7.6 × 10−9). This protective association was particularly evident for alcoholic liver disease (HR = 0.559; 95% CI: 0.347, 0.833; p = 4.3 × 10−3), liver failure (HR = 0.548; 95% CI: 0.343, 0.875; p = 1.2 × 10−2), and non-alcoholic liver disease (HR = 0.784; 95% CI: 0.650, 0.944; p = 1.0 × 10−2). Interestingly, we were able to replicate the association with reduced risk of NAFLD in a subset with liver MRIs (HR = 0.846; 95% CI: 0.777, 0.921; p = 1.1 × 10−4). In particular, women benefited from Omega-3 supplementation as well as heterozygous allele carriers of the liver-damaging variant PNPLA3 rs738409.ConclusionsOmega-3 supplementation may reduce the incidence of liver disease. Our study highlights the potential of personalized treatment strategies for individuals at risk of metabolic liver disease. Further evaluation in clinical trials is warranted before Omega-3 can be recommended for the prevention of liver disease.
Differences in epidemiological and clinical features between adult and pediatric tracheobronchial tuberculosis patients in Southwest China
Authors: Chen Qing , Huang Tao , Zou Liping , Jiang Liangshuang , Sun Jiying , Lu Xiaoli , Huang Xiaoqiu , Wu Guihui , He Wei 
Published: July 2023

BackgroundTracheobronchial tuberculosis (TBTB) is a common form of extrapulmonary tuberculosis that affects the tracheobronchial tree. However, the mechanism has not been fully elucidated. Comparisons of clinical characteristics in various age groups can aid in the understanding of TBTB.MethodsThis retrospective study was conducted at the Public Health Clinical Center of Chengdu between July 2017 and December 2021, including adults and children with TBTB. Clinical data were extracted from medical records. T/T' test, Mann-Whitney U test, Chi-square test, or Fisher's exact test were used in this study.ResultsThis study enrolled 347 patients with TBTB (175 adults and 172 children). Adult females were more susceptible to TBTB, whereas gender-based differences were not observed in children. Children had a higher occurrence of irritant dry cough and fever, and acute hematogenous disseminated PTB, and specific types of EPTB, but a shorter interval before diagnosis, and lower diagnostic yields compared to adults (P &lt; 0.05). Adults presented more extensive lung lesions and cavitations as compared to children. Granulation hyperplasia and lymph fistula were more frequently observed in children, as well as airway stenosis, but less severe.ConclusionsThe study revealed important variations exist in multiple respects between adults and children with TBTB.