bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Paradox of Archiving: Personality Protection and a Threat in One—Archives and Child Sexual Abuse
Authors: Čtvrtník Mikuláš 
Published: January 2023

AbstractPerspectives on the protection of the individual are usually based primarily on the question of how a person and their personality rights may be harmed by the retention and disclosure of data concerning this particular individual. Hence the intentions of the European GDPR to allow for “minimisation” and “storage limitation” when it comes to personal data and the correlating “right to be forgotten” (“right to erasure”). Although these intentions apply primarily to data controllers other than archives, most often of private law provenance, they also apply to archives. Along with this trend, however, the opposite perspective proportionally fades, which is the starting point of this chapter: Apart from the risks associated with the preservation and disclosure of personal data, archiving in the public interest is also one of the tools by which the protection of personality rights can be implemented, even enhanced. Permanent preservation of certain categories of personal data is not only necessary for various future research purposes and official interests, but in some cases such preservation becomes the key guarantee of the protection of personality as well as other human and civil rights. The author will demonstrate this thesis on some specific cases including a specific category of records testifying about sexual abuse inside and outside the Church and the protection of victim rights. An analysis of the opposite situation, in which personal data, especially in archival records, have been misused, will be discussed in more detail in the following chapters.
Confinement in de Sitter space and the swampland
Authors: Mishra Rashmish K. 
Published: January 2023

Abstract
The relation between confinement scale Λc of a gauge theory and the Hubble scale H of the background quasi de Sitter space, required to satisfy the Festina Lente criteria (Λc ≳ H) from swampland principles, are investigated for a holographic theory using the Karch-Randall setup. A purely gravitational description admits an unstable de Sitter extremum, and the requirement of Festina Lente translates into requirements of a perturbative gravitational dual, but prohibits an arbitrarily small hierarchy for other parameters fixed. With an additional scalar sector, the theory admits metastable de Sitter minima, and the requirement of Festina Lente imposes constraints on the parameters. For some range of parameters where Festina Lente could be constraining, the de Sitter minimum is very close to decay, thus invalidating the applicability. Further consequences of the finite lifetime of the dS extrema and the relation with related swampland conjectures are investigated, and no contradictions are found. These results make case for the consistency and utility of the Karch-Randall setup, clarify the implications of Festina Lente for holographic theories, and connect Festina Lente to other swampland conjectures.
Giant Vortices and the Regge Limit
Authors: Cuomo Gabriel , Komargodski Zohar 
Published: January 2023

Abstract
In recent years it has been shown that strongly coupled systems become analytically tractable in the regime of large quantum numbers, such as large spin or large charge. The effective theories that emerge in these two limits are Regge theory and superfluid theory, respectively. Here we make a proposal for a new phase, the “giant vortex,” describing an intermediate regime with large spin and charge. The new phase connects superfluid theory with the large-spin expansion. The giant vortex admits a semi-classical effective theory description with peculiar chiral excitations (moving at the speed of light) and a Fock space of states that is reminiscent of the multi-twist operators in Regge theory, including the leading and daughter Regge trajectories. A similar giant vortex phase appears for Bose-Einstein condensates in a rotating trap, and our results should be applicable in that context as well. We show that the transition from the giant vortex to the Regge regime is accompanied by the scaling dimension turning from being larger than to being smaller than the mean field theory value, i.e. gravity switches from being the weakest force at small AdS distance to being the strongest force at large AdS distance.
Asymptotic symmetries and memories of gauge theories in FLRW spacetimes
Authors: Rojo Martín Enríquez , Schröder Tobias 
Published: January 2023

Abstract
In this paper, we investigate the asymptotic structure of gauge theories in decelerating and spatially flat Friedmann-Lemaître-Robertson-Walker universes. Firstly, we thoroughly explore the asymptotic symmetries of electrodynamics in this background, which reveals a major inconsistency already present in the flat case. Taking advantage of this treatment, we derive the associated memory effects, discussing their regime of validity and differences with respect to their flat counterparts. Next, we extend our analysis to non-Abelian Yang-Mills, coupling it dynamically and simultaneously to a Dirac spinor and a complex scalar field. Within this novel setting, we examine the possibility of constructing Poisson superbrackets based on the covariant phase space formalism.
Relic challenges for vector-like fermions as connectors to a dark sector
Authors: Carvunis Alexandre , McGinnis Navin , Morrissey David E. 
Published: January 2023

Abstract
New dark sectors consisting of exotic fields that couple only very feebly to the Standard Model (SM) have strong theoretical motivation and may be relevant to explaining the abundance of dark matter (DM). An important question for such sectors is how they connect to the SM. For a dark sector with a new gauge interaction, a natural connection arises from heavy vector-like fermions charged under both the visible and dark gauge groups. The gauge charges of such fermions imply that one or more of them is stable in the absence of additional sources of dark symmetry breaking. A generic challenge for such connectors is that they can produce too much dark matter or interact too strongly with nuclei if they were ever thermalized in the early universe. In this paper we study this challenge in a simple connector theory consisting of new vector-like electroweak doublet and singlet fermions that also transform under the fundamental representation of a new Abelian gauge force, and we show that these connectors in their minimal form are almost always ruled out by existing direct DM searches. To address this challenge, we investigate two solutions. First, we study mitigating scattering on nuclei by introducing a Majorana mass term for the singlet. And second, we investigate a mixing with SM leptons that allows the connectors to decay while remaining consistent with cosmological tests and searches for charged lepton flavour violation. Both solutions rely on the presence of a dark Higgs field with a specific charge.
Cytoskeletal anchorage of different Dsg3 pools revealed by combination of hybrid STED/SMFS-AFM
Authors: Fuchs Michael , Radeva Mariya Y. , Spindler Volker , Vielmuth Franziska , Kugelmann Daniela , Waschke Jens 
Published: January 2023

AbstractDesmoglein 3 (Dsg3) is a desmosomal cadherin mediating cell adhesion within desmosomes and is the antigen of the autoimmune blistering skin disease pemphigus vulgaris. Therefore, understanding of the complex desmosome turnover process is of high biomedical relevance. Recently, super resolution microscopy was used to characterize desmosome composition and turnover. However, studies were limited because adhesion measurements on living cells were not possible in parallel. Before desmosomal cadherins are incorporated into nascent desmosomes, they are not bound to intermediate filaments but were suggested to be associated with the actin cytoskeleton. However, direct proof that adhesion of a pool of desmosomal cadherins is dependent on actin is missing. Here, we applied single-molecule force spectroscopy measurements with the novel single molecule hybrid-technique STED/SMFS-AFM to investigate the cytoskeletal anchorage of Dsg3 on living keratinocytes for the first time. By application of pharmacological agents we discriminated two different Dsg3 pools, only one of which is anchored to actin filaments. We applied the actin polymerization inhibitor Latrunculin B to modify the actin cytoskeleton and the PKCα activator PMA to modulate intermediate filament anchorage. On the cellular surface Dsg3 adhesion was actin-dependent. In contrast, at cell–cell contacts, Dsg3 adhesion was independent from actin but rather is regulated by PKC which is well established to control desmosome turn-over via intermediate filament anchorage. Taken together, using the novel STED/SMFS-AFM technique, we demonstrated the existence of two Dsg3 pools with different cytoskeletal anchorage mechanisms.
Low-dose radiotherapy of osteoarthritis: from biological findings to clinical effects—challenges for future studies
Authors: Weissmann Thomas , Rückert Michael , Putz Florian , Donaubauer Anna-Jasmina , Hecht Markus , Schnellhardt Sören , Schubert Philipp , Roesch Johannes , Höfler Daniel , Ott Oliver J. , Haderlein Marlen , Lettmaier Sebastian , Fietkau Rainer , Frey Benjamin , Gaipl Udo S. , Deloch Lisa 
Published: January 2023

AbstractOsteoarthritis (OA) is one of the most common and socioeconomically relevant diseases, with rising incidence and prevalence especially with regard to an ageing population in the Western world. Over the decades, the scientific perception of OA has shifted from a simple degeneration of cartilage and bone to a multifactorial disease involving various cell types and immunomodulatory factors. Despite a wide range of conventional treatment modalities available, a significant proportion of patients remain treatment refractory. Low-dose radiotherapy (LDRT) has been used for decades in the treatment of patients with inflammatory and/or degenerative diseases and has proven a viable option even in cohorts of patients with a rather poor prognosis. While its justification mainly derives from a vast body of empirical evidence, prospective randomized trials have until now failed to prove the effectiveness of LDRT. Nevertheless, over the decades, adaptions of LDRT treatment modalities have evolved using lower dosages with establishment of different treatment schedules for which definitive clinical proof is still pending. Preclinical research has revealed that the immune system is modulated by LDRT and very recently osteoimmunological mechanisms have been described. Future studies and investigations further elucidating the underlying mechanisms are an essential key to clarify the optimal patient stratification and treatment procedure, considering the patients’ inflammatory status, age, and sex. The present review aims not only to present clinical and preclinical knowledge about the mechanistic and beneficial effects of LDRT, but also to emphasize topics that will need to be addressed in future studies. Further, a concise overview of the current status of the underlying radiobiological knowledge of LDRT for clinicians is given, while seeking to stimulate further translational research.
Nachhaltigkeit in der chirurgischen Niederlassung – ein narratives Review
Authors: Mezger Nikolaus Christian Simon , Eickel Florian , Lorenz Ralph , Griesel Mirko 
Published: January 2023

Zusammenfassung
Hintergrund
Auch die ambulante Chirurgie trägt zur Klimakrise bei. Die Publikation soll die Herausforderungen identifizieren und klare, möglichst evidenzbasierte Empfehlungen für Umweltschutz bei gleichzeitiger Kostenreduktion geben.

Methode
Narratives Review mit nichtsystematischer umfangreicher Recherche in PubMed/MEDLINE und grauer Literatur sowie Befragung von Expert:innen.

Ergebnisse
Eine Vielzahl an Primärarbeiten, Evidenzsynthesen, praktischen Handlungsempfehlungen und Checklisten konnte identifiziert und zwei Expert:innen befragt werden. Umweltprobleme wurden erkannt in Produktion und Beschaffung, Verkehr, beim Verbrauch von Material, Pharmaka und Energie sowie bei Entsorgung, Wiederverwertung und Sterilisation. Hochwertige Publikationen beschreiben nicht einen Mangel an Wissen um Alternativen, sondern an praktischer Umsetzung. Deshalb wurden die Probleme in das 5‑R-Schema („reduce“, „reuse“, „recycle“, „rethink“, „research“) eingeordnet, um Handlungsempfehlungen mit Synergieeffekten bezüglich Kostenreduktion, Patient:innen- und Mitarbeiter:innenzufriedenheit zu präsentieren. Des Weiteren werden Veränderungen der Rahmenbedingungen diskutiert.

Schlussfolgerung
Ambulantes Operieren geht mit relevantem Ressourcenverbrauch einher. Es existieren zahlreiche Möglichkeiten, Umweltschutz mit Kostenreduktion sowie Zufriedenheit von Patient:innen und Mitarbeiter:innen zu verbinden. Für flächendeckenden Klimaschutz in der Niederlassung müssen Anreize und gesetzliche Rahmenbedingungen geschaffen werden.
Sustained clinical success at 7-year follow-up after arthroscopic Lift-Drill-Fill-Fix (LDFF) of primary osteochondral lesions of the talus
Authors: Rikken Quinten G. H. , Altink J. Nienke , Dahmen Jari , Lambers Kaj T. A. , Stufkens Sjoerd A. S. , Kerkhoffs Gino M. M. J. 
Published: January 2023

Abstract
Purpose
To describe the long-term clinical results of arthroscopic fragment fixation for chronic primary osteochondral lesions of the talus (OLT), using the Lift-Drill-Fill-Fix (LDFF) technique.

Methods
Eighteen patients (20 ankles) underwent fixation for a primary OLT with an osteochondral fragment using arthroscopic LDFF and were evaluated at a minimum of 5-year follow-up. Pre- and postoperative clinical assessment was prospectively performed by measuring the Numeric Rating Scale (NRS) of pain at rest, during walking and when running. Additionally, the change in Foot and Ankle Outcome Score (FAOS) and the procedure survival (i.e., no reoperation for the OLT) at final follow-up was assessed.

Results
At a mean follow-up of 7 years, the median NRS during walking significantly improved from 7 (IQR 5–8) pre-operatively to 0 (IQR 0–1.5) at final follow-up (p =  < 0.001). This result was sustained from 1-year follow-up to final follow-up. The NRS during running significantly improved from 8 (IQR 6−10) to 2 (IQR 0–4.5) (p < 0.001) and the NRS in rest from 2.5 (IQR 1–3) to 0 (IQR 0–0) (p =  < 0.001). The median FAOS at final follow-up was 94 out of 100 for pain, 71 for other symptoms, 99 for activities of daily living, 80 for sport and 56 for quality of life. The FOAS remained significantly improved post-operatively on all subscales, except for the symptoms subscale. The procedure survival rate is 87% at final follow-up.

Conclusion
Arthroscopic LDFF for fixable chronic primary OLTs results in excellent pain reduction and improved patient-reported outcomes, with sustained results at long-term follow-up. These results indicate that surgeons may consider arthroscopic LDFF as treatment of choice for fragmentous OLT.

Level of evidence
Level IV, prospective case series.
Bacillus predominates in the Ophiocordyceps pseudolloydii-infected ants, and it potentially improves protection and utilization of the host cadavers
Authors: Kuo Hao-Yu , Chiu Ming-Chung , Chou Jui-Yu 
Published: January 2023

AbstractThe bacterial communities that colonize the cadaver environment of insects infected and killed by parasitic fungi can be selected by the sympatric fungi and provide novel impacts. In this study, we found that Bacillus cereus/thuringiensis predominate the bacterial community in Dolichoderus thoracicus ant cadavers colonized by O. pseudolloydii. The most predominant bacterial strains in these ant cadavers were hemolytic and able to produce hydrolytic enzymes for digesting the ant tissue. A relatively intense lethal effect on the co-cultured nematode was displayed by a hemolytic strain. Moreover, the antagonistic effect against pathogenic fungi detected in the bacteria sympatric with O. pseudolloydii was reported here. Naphthoquinones have been shown to confer antibacterial activities and produced by the ant-pathogenic Ophiocordyceps fungi. However, our results did not show the naphthoquinone tolerance we expected to be detected in the bacteria from the ant infected by O. pseudolloydii. The bacterial diversity in the samples associated with O. pseudolloydii infected ants as revealed in this study will be a step forward to the understanding of the roles playing by the microbial community in the native habitats of O. pseudolloydii.
Fitting ideals and various notions of equivalence for modules
Authors: Greither Cornelius , Kataoka Takenori 
Published: January 2023

AbstractRecently there has been a lot of work on determining the Fitting ideals of arithmetic modules over groups rings, first and foremost of class groups and their Pontryagin duals. In particular, it has turned out that these Fitting ideals are usually non-principal and may be described, up to principal ideals, in terms of group-theoretical information only. The involved principal ideal factors are essentially given by values of equivariantL-functions. The present paper is not concerned with theseL-functions but rather focuses on a systematic understanding of the Fitting ideals up to principal factors. To this end, we develop a certain notion of “equivalence of modules” over suitable commutative ringsR. We establish that understanding the equivalence ofR-modules is closely related to the classification ofR-lattices. We also offer a construction of a category, inspired by derived categories, which embodies our new notion of “equivalence”.
Computed tomography and magnetic resonance imaging of congenital thoracic systemic venous anomalies
Authors: Batouty Nihal M. , Tawfik Ahmed M. , Sobh Donia M. , Razek Ahmed A. K. A. 
Published: January 2023

AbstractWe present the imaging findings of thoracic systemic venous anomalies diagnosed by computed tomography and magnetic resonance imaging. Persistent left superior vena cava is the commonest anomaly of the thoracic systemic veins encountered either incidentally as an isolated finding or associated with congenital heart disease. Inferior vena cava (IVC) interruption with azygos continuation is the second most common anomaly, which may also be isolated or be associated with left isomerism syndrome. The article will also discuss other rarer systemic venous anomalies including retroaortic brachiocephalic vein and IVC drainage into the left atrium. Finally, the impact of pre-procedure reporting of thoracic systemic venous anomalies on the choice of intervention and patient outcome will be addressed.
PSMA PET/CT: joint EANM procedure guideline/SNMMI procedure standard for prostate cancer imaging 2.0
Authors: Fendler Wolfgang P. , Eiber Matthias , Beheshti Mohsen , Bomanji Jamshed , Calais Jeremie , Ceci Francesco , Cho Steve Y. , Fanti Stefano , Giesel Frederik L. , Goffin Karolien , Haberkorn Uwe , Jacene Heather , Koo Phillip J. , Kopka Klaus , Krause Bernd J. , Lindenberg Liza , Marcus Charles , Mottaghy Felix M. , Oprea-Lager Daniela E. , Osborne Joseph R. , Piert Morand , Rowe Steven P. , Schöder Heiko , Wan Simon , Wester Hans-Jürgen , Hope Thomas A. , Herrmann Ken 
Published: January 2023

AbstractHere we aim to provide updated guidance and standards for the indication, acquisition, and interpretation of PSMA PET/CT for prostate cancer imaging. Procedures and characteristics are reported for a variety of available PSMA small radioligands. Different scenarios for the clinical use of PSMA-ligand PET/CT are discussed. This document provides clinicians and technicians with the best available evidence, to support the implementation of PSMA PET/CT imaging in research and routine practice.
Effects of the STAMP-inhibitor asciminib on T cell activation and metabolic fitness compared to tyrosine kinase inhibition by imatinib, dasatinib, and nilotinib
Authors: Häselbarth Lukas , Karow Axel , Mentz Kristin , Böttcher Martin , Roche-Lancaster Oisin , Krumbholz Manuela , Jitschin Regina , Mougiakakos Dimitrios , Metzler Markus 
Published: January 2023

AbstractT cell function is central to immune reconstitution and control of residual chronic myeloid leukemia (CML) cells after treatment initiation and is associated with achieving deep molecular response as a prerequisite for treatment-free remission, the ultimate therapeutic goal in CML. ATP-pocket-binding tyrosine kinase inhibitors (TKIs) like imatinib, dasatinib, and nilotinib are widely used for treating CML, but they have shown to inhibit T cell function as an “off-target” effect. Therefore, we tested asciminib, the first-in-class BCR::ABL1 fusion protein inhibitor specifically targeting the ABL myristoyl pocket (STAMP) and compared its effects on T cell function with imatinib, dasatinib, and nilotinib. Whereas all four TKIs inhibited the expression of the co-stimulatory protein CD28, the amino acid transporter CD98, proliferation, and secretion of pro-inflammatory cytokines IFNγ, IL-6, and IL-17A upon T cell stimulation, asciminib had less impact on PD-1, activation markers, and IL-2 secretion. T cells treated with asciminib and the other TKIs maintained their ability to mobilize their respiratory capacity and glycolytic reserve, which is an important surrogate for metabolic fitness and flexibility. Overall, we found milder inhibitory effects of asciminib on T cell activation, which might be beneficial for the immunological control of residual CML cells.
Experimental characterization of an unsteady laminar separation bubble on a pitching wing
Authors: Grille Guerra Adrian , Mertens Christoph , Little Jesse , van Oudheusden Bas 
Published: January 2023

AbstractThe laminar separation bubble (LSB) that forms on the suction side of a modified NACA$$64_3$$643-618 airfoil at a chord-based Reynolds number of$$\textrm{Re} = 200,000$$Re=200,000is studied using wind tunnel experiments. First, the LSB is characterized over a range of static angles of attack, in terms of the locations of separation, transition and reattachment—using surface pressure measurements, particle image velocimetry (PIV) and infrared thermography (IT). For the conditions tested, excellent agreement between the techniques is obtained. Subsequently, a pitching motion is imposed on the wind tunnel model, with reduced frequencies up to$$\text {\textit{k} = 0.25}$$k = 0.25. While surface pressure measurements and PIV are not affected by the change in experimental conditions, the infrared approach is impaired by the thermal response of the surface. To overcome this, an extension of the differential infrared thermography (DIT) method for detecting the three characteristics of an unsteady LSB is considered. All three experimental techniques indicate a hysteresis in bubble location between the pitch up and pitch down phases of the motion, caused by the effect of the aerodynamic unsteadiness on the adverse pressure gradient. However, the DIT measurements suggest a larger hysteresis, which is attributed to the thermal response time of the model surface. The experimental results measured with the pressure sensors reveal that the hysteresis in bubble location is larger than the hysteresis in lift, indicating that the observed bubble hysteresis is not purely due to instantaneous flow conditions, but has an inherent component as well.