bluuebunny/crossref_metadata_2025_split huggingface dataset:
Developing adaptability and agility in leadership amidst the COVID-19 crisis: experiences of early-career school principals
Authors: Fernandes Venesser , Wong Winnie , Noonan Michael 
Published: March 2023

PurposeDuring the COVID-19 crisis in Victoria, Australia the complexity of school leadership increased greatly for school principals. This study focused on the lived experiences of early career principals in the independent school sector from March to November 2020 in Victoria, Australia. It investigates transformative work that was undertaken by these leaders in leading their schools over a protracted crisis.Design/methodology/approachThe study builds on constructs of crisis leadership, adaptive leadership, agile leadership and emotional intelligence, exploring the leadership approaches undertaken by twenty-two early career principals in Victoria, Australia. Using a narrative inquiry approach, across three temporal points in 2020, storied productions drawn from the findings present four emergent types of emotionally intelligent leadership approaches undertaken by these principals. These leadership approaches are presented as the commander-leader, the conductor-leader, the gardener-leader and the engineer-leader with each approach demonstrating both organisational leadership approaches as well as individual leadership styles used by these principals as they led their schools.FindingsThe findings have direct implications for professional development programs focusing on aspiring principals and early career principals with emphasis on the importance of developing emotionally intelligent skillsets in principals for use during periods of rapid change or high crisis in schools. The findings present insight into the support useful for early career principals in the first five years of principalship.Originality/valueThis study uses a unique emotional intelligence approach to understand school leadership during and after a crisis.
Rural electrification and women's empowerment in Côte d’Ivoire
Authors: Bago Jean-Louis , Djezou Wadjamsse , Tiberti Luca , Achy Landry 
Published: March 2023

PurposeThis paper assesses the impact of this program on the rural women's employment opportunities using data from the 2015 round of the household's living standard survey (HLSS) of Côte d'Ivoire.Design/methodology/approachIn 2013, in order to improve the living conditions of the rural population, the Ivorian government launched the National Program for rural electrification (PRONER) to electrify all localities with more than 500 inhabitants.FindingsThe results show that PRONER, while reducing the time allocated to performing household chores, increases women's employment through the reallocation of time to full-time paid work in the agricultural and non-agricultural sectors. The authors also find that the allocation of men's time is not affected by this programme. A possible mechanism that would explain such a pro-women effect is the labour-saving technology introduced to home production as an effect of the reform.Research limitations/implicationsAs a limitation, it is important to note that these results were obtained in the specific context of PRONER in Côte d’Ivoire and are not necessarily applicable to rural electrification programmes in other contexts. Furthermore, the choice of other indicators to measure women's empowerment is limited by the quality of the data available. It would be interesting for future research to extend this analysis to include other aspects of women's empowerment and household welfare.Originality/valueThis paper is the first to the author’s knowledge to apply a robust econometric method by combining an inverse probability weighted regression adjustment model with Heckman sample selection method to access a robust causal effect of the PRONER in Côte d'Ivoire.
The social media industry: where is it heading?
Authors: Zhang Yanli , Nguyen Huy Will , Jung Young Hoon , Ren Isabelle Yi 
Published: March 2023

Purpose
The social media industry has entered a new stage with intensifying competition and heightened uncertainty about future directions. The purpose of this paper is to provide analyses of the current challenges and to identify industry-wide trends that may offer a roadmap for the future.

Design/methodology/approach
Drawing on publicly available key performance metrics, company reports and press reports, this paper offers critical analyses of the challenges facing the major social media platforms and new trends in the social media industry.

Findings
This study identified five major trends in the current social media industry: 1) content is king, and that content is moving to visual; 2) artificial intelligence is key to competitive advantage; 3) network effects still matter, but business model innovation can overcome that barrier; 4) the need to broaden revenue sources; and 5) the strive for the everything app. In this changing environment, social media companies need to adapt and innovate their business models proactively to stay ahead.

Originality/value
This paper not only sheds light on the current challenges of individual social media platforms but also identifies industry-wide trends that may apply across all platforms. Taken together, these insights paint a comprehensive picture of the current industry landscape, as well as offer clues about its future directions.
Challenges in determining whether youth with autism spectrum disorder have been sexually abused: implications for forensic interviewing
Authors: Goldberg Edelson Meredyth 
Published: March 2023

Purpose
The purpose of this paper is to educate forensic interviewers about autism spectrum disorder (ASD) and tools for interviewing youth with ASD when there are concerns of child sexual abuse (CSA).

Design/methodology/approach
Research is reviewed to discuss risk factors for CSA in youth with ASD, why CSA is often not recognized and research-based strategies for forensically interviewing youth with ASD.

Findings
Youth with ASD are at increased risk of CSA compared to neurotypical peers, but recognition of CSA in youth with ASD can be difficult. Forensic interviewing strategies can help interviewers obtain reports of CSA from youth with ASD.

Practical implications
Given the increase in prevalence of ASD and the increased risk of CSA, forensic interviewers need to have information about ASD, about why CSA may not be recognized, about risk factors for CSA and, especially, about how to accommodate for ASD when conducting forensic interviews.

Originality/value
This paper provides a novel framework for considering evidence-based practices for forensically interviewing youth with ASD when there are concerns of CSA. Specifically, this paper includes multiple, but related areas, in one article including research related to ASD, risk factors for CSA in those with ASD, obstacles to identifying CSA and the implications of this research for specific strategies regarding how to forensically interview youth with ASD when there are concerns of CSA.
Working Online During the Contemporary COVID‐19 Pandemic1
Authors: Merchant John 
Published: March 2023

AbstractWithin the psychoanalytic school there has been substantial and ongoing debate about the efficacy of teleanalysis. However, as a result of the current COVID‐19 pandemic and the online work with which the Jungian analytic community has now had to engage, this paper initially focuses on analysts’ actual experiences of working by teleanalysis. These experiences highlight a range of issues like “Zoom fatigue”, “online disinhibition”, dissonance, confidentiality, the frame and working with new patients. Alongside these issues, there were ample experiences by analysts of both productive psychotherapy apace with analytic work involving transference and countertransference phenomena, all indicating that a genuine and good enough analytic process can occur with teleanalysis. An overview of the research and literature both prior to the pandemic and as a result of it, confirms the validity of these experiences so long as analysts are cognizant of the specifics of such an online modality. Conclusions to do with the question, “what have we learned?”, alongside training, ethics and supervision issues are subsequently discussed.
Good practice: The experiences with the utilization of residual cancer burden—A single institution study
Authors: Sejben Anita , Hegedűs Fanni , Almási Szintia , Berta Márton , Oláh‐Németh Orsolya , Zombori Tamás 
Published: March 2023

AbstractIntroductionThe use of neoadjuvant therapy (NAT) has been showing an incraesing tendency in the treatment of locally advanced breast cancer. The evaluation of residual cancer could be performed by Residual Cancer Burden (RCB) calculator. The prognostic system takes the two largest diameters of the tumor, the cellularity, the amount of in situ carcinoma, the number of metastatic lymph nodes, and the size of the largest metastatic deposit into account. The aim of our study was to examine the reproducibility of RCB in NAT treated patients.MethodsPatients who were treated with NAT and had resection specimens between 2018 and 2021 were selected. Histological examination was performed by five pathologists. After assessment of the examined variables, RCB points and RCB classes were defined. For statistical analysis, interclass correlation was used (SPSS Statistics V.22.0 software).ResultsAltogether 100 patients were included in our retrospective, cohort study (average age: 57 years). In two‐thirds of the cases, third generation chemotherapy was used, and mastectomy was performed. Significant concordance was found in the two largest diameters of the tumor (coefficients, 0.984 and 0.973), the cellularity (coefficient, 0.970), and the largest metastatic deposit (coefficient, 0.998). Although the amount of in situ carcinoma proved to be the least reproducible factor, it resulted in almost 90% of agreement (coefficient, 0.873). Regarding RCB points and classes, similar results were observed (coefficients, 0.989 and 0.960).ConclusionsSignificant agreement was observed between examiners based on almost all RCB parameters, points, and classes, reflecting the optimal reproducibility of RCB. Therefore, we recommend the use of the calculator in routine histopathological reports in NAT cases.
Veno‐arterial CO2 difference and lactate for prediction of early mortality after cardiac arrest
Authors: Lundin Andreas , Annborn Martin , Borgquist Ola , Düring Joachim , Undén Johan , Rylander Christian 
Published: March 2023

AbstractPatients admitted to intensive care after cardiac arrest are at risk of circulatory shock and early mortality due to cardiovascular failure. The aim of this study was to evaluate the ability of the veno‐arterial pCO2 difference (∆pCO2; central venous CO2 – arterial CO2) and lactate to predict early mortality in postcardiac arrest patients. This was a pre‐planned prospective observational sub‐study of the target temperature management 2 trial. The sub‐study patients were included at five Swedish sites. Repeated measurements of ∆pCO2 and lactate were conducted at 4, 8, 12, 16, 24, 48, and 72 h after randomization. We assessed the association between each marker and 96‐h mortality and their prognostic value for 96‐h mortality. One hundred sixty‐three patients were included in the analysis. Mortality at 96 h was 17%. During the initial 24 h, there was no difference in ∆pCO2 levels between 96‐h survivors and non‐survivors. ∆pCO2 measured at 4 h was associated with an increased risk of death within 96 h (adjusted odds ratio: 1.15; 95% confidence interval [CI]: 1.02–1.29; p = .018). Lactate levels were associated with poor outcome over multiple measurements. The area under the receiving operating curve to predict death within 96 h was 0.59 (95% CI: 0.48–0.74) and 0.82 (95% CI: 0.72–0.92) for ∆pCO2 and lactate, respectively. Our results do not support the use of ∆pCO2 to identify patients with early mortality in the postresuscitation phase. In contrast, non‐survivors demonstrated higher lactate levels in the initial phase and lactate identified patients with early mortality with moderate accuracy.
When my neighbors matter: Spillover effects in the adoption of large‐scale pesticide‐free wheat production
Authors: Wang Yanbing , Möhring Niklas , Finger Robert 
Published: March 2023

AbstractWe investigate the spillover effects in farmers’ adoption decisions of a novel pesticide‐free wheat production system. To this end, we exploit the variability and asymmetry in the social ties among neighboring farmers. We find evidence of spillover effects in farmers’ adoption decisions as well as in farm and farmer characteristics. Our results further highlight the importance of accounting for potentially heterogeneous social ties in farmer networks beyond pure measures of spatial proximity: spillover effects are only robust once we account for the strength of social ties through farmers’ stated tendency to consult peers on agricultural decisions. Our findings highlight the relevance of peer influence in the diffusion of sustainable agriculture practices even in contexts of well‐functioned institutions and high interest in environmental protection such as European agriculture. We discuss implications for the design of policies and programs for sustainable agriculture, which are currently in the center of attention in agricultural policymaking.
A novel XPA splice‐site mutation identified in a 4‐year‐old Filipino girl with xeroderma pigmentosum
Authors: Reyes Haider H. , Lin Yu‐Chen , Hsu Chao‐Kai , Guevara Bryan Edgar K. 
Published: March 2023

AbstractWe herein report a case of a 4‐year‐old Filipino girl initially seen through online consultation from a general physician. She was born to a 22‐year‐old primigravid mother, with no birth complications nor a history of consanguinity in the family. During the 1st month of life, she developed hyperpigmented macules over the face, neck, upper back, and limbs, which were exacerbated by sun exposure. At 2 years old, she developed a solitary erythematous papule on the nasal area, which gradually enlarged within one year and developed into an exophytic ulcerating tumor extending to the right supra‐alar crease. Xeroderma pigmentosum and squamous cell carcinoma were confirmed by whole‐exome sequencing and skin biopsy, respectively.
Childhood manifestations of 22q11.2 deletion syndrome: A Finnish nationwide register‐based cohort study
Authors: Wahrmann Sakari , Kainulainen Leena , Kytö Ville , Lempainen Johanna 
Published: March 2023

AbstractAimThe aim of the study was to describe the clinical manifestations of 22q11.2 deletion syndrome patients in the Finnish paediatric population.MethodsNationwide registry data including all diagnoses and procedures of every public hospital in Finland between 2004 and 2018 along with mortality and cancer registry data were retrieved. Patients born during the study period and with an ICD‐10 code of D82.1 or Q87.06 were included as having 22q11.2 deletion syndrome. A control group was formed with patients born during the study period and with benign cardiac murmur diagnosed under the age of 1 year.ResultsWe identified 100 pediatric patients with 22q11.2 deletion syndrome (54% males, median age at diagnosis <1 year, median follow‐up 9 years). Cumulative mortality was 7.1%. Among patients with 22q11.2 deletion syndrome, 73.8% had congenital heart defects, 21.8% had cleft palate, 13.6% had hypocalcaemia, and 7.2% had immunodeficiencies. Furthermore, 29.6% were diagnosed with autoimmune diseases, 92.9% had infections, and 93.2% had neuropsychiatric and developmental issues during follow‐up. Malignancy was found in 2.1% of the patients.ConclusionThe 22q11.2 deletion syndrome is associated with increased mortality and substantial multimorbidity in children. A structured multidisciplinary approach is necessary for managing patients with 22q11.2 deletion syndrome.
Long‐term milrinone therapy in children with dilated cardiomyopathy
Authors: Brown Samuel , Nolan Oscar , Poole Esther , Kidd Justine , Cassidy Jane , Botha Phil , Chaudhari Milind 
Published: March 2023

AbstractAimThe aim of this study was to assess the safety and efficacy of long‐term milrinone therapy in children with acute decompensated heart failure due to dilated cardiomyopathy (DCM).MethodsA single‐centre retrospective study of all children ≤18 years with acute decompensated heart failure and DCM who received continuous long‐term (≥7 consecutive days) intravenous milrinone between January 2008 and January 2022.ResultsThe 47 patients had a median age of 3.3 months [interquartile range (IQR) 1.0–18.1], weight of 5.7 kg [IQR 4.3–10.1] and fractional shortening of 11.9% [±4.7]. Idiopathic DCM (n = 19) and myocarditis (n = 18) were the most common diagnoses. The median milrinone infusion duration was 27 days [IQR 10–50, range 7–290]. No adverse events necessitated milrinone termination. Nine patients required mechanical circulatory support. Median follow‐up was 4.2 years [IQR 2.7–8.6]. On initial admission, four patients died, six were transplanted and 79% [37/47] were discharged home. The 18 readmissions resulted in five more deaths and four transplantations. Cardiac function recovered in 60% [28/47], as measured by normalised fractional shortening.ConclusionLong‐term intravenous milrinone is safe and effective in paediatric acute decompensated DCM. Combined with conventional heart failure therapies, it can act as a bridge to recovery and thereby potentially reduce the need for mechanical support or heart transplantation.
Mitochondrial respiratory chain activity is associated with severity, corticosteroid response and prognosis of alcoholic hepatitis
Authors: Solís‐Muñoz Pablo , de la Flor‐Robledo María , García‐Ruíz Inmaculada , Fernández‐García Carlos E. , González‐Rodríguez Águeda , Shah Naina , Bataller Ramón , Heneghan Michael , García‐Monzón Carmelo , Solís‐Herruzo José A. 
Published: March 2023

SummaryBackground and AimsLittle is known about the extent of mitochondrial respiratory chain (MRC) activity dysfunction in patients with alcoholic hepatitis (AH). We aimed to assess the hepatic MRC activity in AH patients and its potential impact on the severity and prognosis of this life‐threatening liver disease.MethodsMRC complexes were measured in liver biopsies of 98 AH patients (non‐severe, 17; severe, 81) and in 12 histologically normal livers (NL). Severity was assessed according to Maddrey's Index and MELD score. Corticosteroid response rate and cumulative mortality were also evaluated.ResultsThe activity of the five MRC complexes was markedly decreased in the liver of AH patients compared with that of NL subjects, being significantly lower in patients with severe AH than in those with non‐severe AH. There was a negative correlation between the activity of all MRC complexes and the severity of AH. Interestingly, only complex I and III activities showed a significant positive correlation with the corticosteroid response rate and a significant negative correlation with the mortality rate at all‐time points studied. In a multivariate regression analysis, besides the MELD score and the corticosteroid response rate, complex I activity was significantly associated with 3‐month mortality (OR = 6.03; p = 0.034) and complex III activity with 6‐month mortality (OR = 4.70; p = 0.041) in AH patients.ConclusionOur results indicate that MRC activity is markedly decreased in the liver of AH patients, and, particularly, the impairment of MRC complexes I and III activity appears to have a significant impact on the clinical outcomes of patients with AH.
Same‐day discharge robot‐assisted laparoscopic prostatectomy: feasibility, safety and patient experience
Authors: Hill George Thomas , Jeyanthi Mekha , Coomer William , Bryant Richard J. , Colmsee Matthew T. , Tozer James , Cox Adam Christopher , Wilson Jim R. 
Published: March 2023

ObjectivesTo report a single centre's experience of the feasibility, safety and patient acceptability of same‐day discharge robot‐assisted laparoscopic prostatectomy (RALP).Subjects/Patients and MethodsBetween June 2015 and December 2021, a total of 180 pre‐selected consecutive patients underwent RALP with the intention to discharge on the same day as surgery. Cases were performed by two surgeons. An enhanced recovery after surgery (ERAS) programme was used. The feasibility of same‐day discharge was analysed, along with the complication rate, oncological outcomes, and postoperative patient experience.ResultsOf 180 patients, 169 (93.8%) were successfully discharged on the same day as surgery. The median (range) age was 63 ( 44–74) years. The median (range) console time was 97 (61–256) min and blood loss was 200 (20–800) mL. The resection specimen pathology results were: pT2 69.4%, pT3a 24.4% and pT3b 6.5%. With regard to Gleason Grade Group (GGG), 25.9% had GGG 1, 65.7% had GGG 2–3 and 8.4% had GGG 4–5 disease. Positive surgical margins were present in 25 cases (14.7%), 18 (15.5%) of which occurred in pT2 cases, and seven (13.4%) in pT3 cases. There were no early (<90 days) biochemical relapses (defined as prostate‐specific antigen level >0.2 ng/mL). The 30‐day readmission rate was 3%. A total of 13 early (0–30 days) complications were observed, five of which were Clavien–Dindo grade ≥3, however, none of these would have been avoided had the patient remained in hospital on the first postoperative night. Of 121 consecutive patients, 107 (88%) returned a satisfaction questionnaire, and 92% of responders stated they preferred recovery at home, with 94% stating they felt ready to go home.ConclusionRobot‐assisted laparoscopic prostatectomy combined with an ERAS programme allows patients to be safely discharged home on the same day of their surgery. This is a feasible option, well‐liked by patients, with morbidity and oncological outcomes similar to non‐day‐case or 23 h stay RALP.
Selection of highly responsive T cell receptors by an analysis combining the expression of multiple markers
Authors: Thi Viet Ha My , Hamana Hiroshi , Shitaoka Kiyomi , Hayee Abdul , Kobayashi Eiji , Yoshikawa Toshiaki , Nakatsura Tetsuya , Saikawa Reiko , Sato Eri , Osawa Mitsujiro , Hitoshi Yasumichi , Son Dang Tung , Ozawa Tatsuhiko , Kishi Hiroyuki 
Published: March 2023

AbstractThe clinical success of T cell receptor (TCR) gene–transduced T (TCR‐T) cell therapy is expected as one of the next‐generation immunotherapies for cancer, in which the selection of TCRs with high functional avidity (high‐functional TCRs) is important. One widely used approach to select high‐functional TCRs is a comparison of the EC50 values of TCRs, which involves laborious experiments. Therefore, the establishment of a simpler method to select high‐functional TCRs is desired. We herein attempted to establish a simple method to select high‐functional TCRs based on the expression of T cell activation markers using the mouse T cell line BW5147.3 (BW). We examined relationships between the EC50 values of TCRs in interleukin‐2 production and the expression levels of TCR activation markers on BW cells. In TCR‐expressing BW cells stimulated with antigenic peptides, the CD69, CD137, and PD‐1 expression was differentially induced by various doses of peptides. An analysis of TCRs derived from the tumor‐infiltrating lymphocytes of murine melanoma and peripheral blood T cells of hepatocellular carcinoma patients treated with a peptide vaccination revealed that an analysis combining CD69, CD137, and PD‐1 expression levels in BW cells stimulated with a single dose of an antigenic peptide selected high‐functional TCRs with functional avidity assessed by EC50 values. Our method facilitates the section of high‐functional TCRs among tumor‐reacting TCRs, which will promote TCR‐T cell therapy. The stimulation of BW cells expressing objective TCRs with a single dose of antigenic peptides and analysis combining the expression of CD69, CD137, and PD‐1 allows us to select highly responsive TCRs.