bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fathering and children's relational aggression: Moderating effects of children's temperament and gender
Authors: Carreras Rosario , Martín Alba , Ruiz‐Ortiz Rosa , Pascual‐Sagastizábal Eider , del Puerto‐Golzarri Nora , Azurmendi Aitziber , Braza Paloma , Muñoz José M. 
Published: February 2023

AbstractIn this exploratory study, we analyzed the contribution of fathering to relational aggression (RA) in middle childhood and the moderating role of children's temperament and gender. Participants (N = 234; 46% girls) were attending public elementary school (mean age = 8.15; SD = 1.23) in middle‐class neighborhoods in two Spanish cities. Fathers provided information about their parenting practices using the Parenting Styles and Dimensions Questionnaire, parents gave data on their child's temperament using the Temperament in Middle Childhood Questionnaire and children provided information about their peers’ aggressive behavior using the Mini Direct Indirect Aggression Inventory. Fathering dimensions considered were Authoritative Cold, Authoritative Warm, Physical Punishment, and Insecurity; temperament dimensions considered were negative affect (NA), effortful control (EC), activity (AC), and shyness (SH). Gender, fathering, and temperament dimensions additively accounted for a significant proportion of the variance observed in RA. Several significant interactions suggested that the effect of fathering on RA was moderated by temperament and, in some cases, by children's gender. NA increased the potential risk of Authoritative Cold fathering (CF) and, in boys only, of Insecure fathering, while EC potentiated the protective effect of Authoritative‐Warm fathering and, in boys only, buffered the risk effect of CF. SH buffered the risk effect of CF and decreased the protective effect of Authoritative Warm fathering on RA. Lastly, AC also buffered the risk effect of CF on RA. Results are discussed in light of the protective or the vulnerability role of temperament and in relation to models that explain sensitivity differences to environmental contexts.
Relational model of relative deprivation, revenge, and cyberbullying: A three‐time longitudinal study
Authors: Guo Yongfen , Xia Ling‐Xiang 
Published: February 2023

AbstractCyberbullying is a new form of aggression and can have serious consequences. Although the influencing factors of cyberbullying have been explored in the literature, less is known of the longitudinal effects of relative deprivation on cyberbullying and the mediating mechanisms underlying the effect. In this study, we explored these problems. A total of 1143 undergraduates (62.9% women, mean age = 19.46, standard deviation [SD] = 0.95) participated in three rounds of a longitudinal survey with an interval of 6 months and completed a series of self‐reported questionnaires assessing relative deprivation, revenge, and cyberbullying. The results of random intercept cross‐lagged panel model showed that at between‐person level, the random intercepts of relative deprivation, revenge, and cyberbullying were positively associated with each other. At within‐person level, relative deprivation and revenge could predict each other over time, and revenge longitudinally predicted cyberbullying. Moreover, revenge mediated the longitudinal effect of relative deprivation on cyberbullying. The results support and develop the view of the general aggression model and deepen our understanding of the development mechanism of cyberbullying.
Directing Group‐Free Regioselective meta‐C−H Functionalization of Pyridines
Authors: Chakraborty Sukriyo , Biju Akkattu T. 
Published: February 2023

AbstractThe pyridine core is among the most common motifs found in pharmaceuticals and agrochemicals. Consequently, the C−H functionalization of pyridine is a prized reaction, as it can help access a broad spectrum of valuable chemicals. However, the intrinsic electronic properties of pyridines hinder their meta‐C−H functionalization, requiring drastic conditions affecting functional group compatibility. A synthetic manoeuvre to overcome this challenge involves the temporary conversion of pyridines into electron‐rich intermediates and subsequent regioselective electrophilic functionalization. This was recently accomplished by a ring‐opening ring‐closing sequence via Zincke imine intermediates by McNally and co‐workers, and a dearomatization‐rearomatization sequence via oxazino‐pyridine intermediates by the Studer group. The mildness and simplicity of these protocols enable them to work with complex molecular setups for synthesizing natural products and bioactive molecules.
Mitigating Swelling of the Solid Electrolyte Interphase using an Inorganic Anion Switch for Low‐temperature Lithium‐ion Batteries
Authors: Liang Jia‐Yan , Zhang Yanyan , Xin Sen , Tan Shuang‐Jie , Meng Xin‐Hai , Wang Wen‐Peng , Shi Ji‐Lei , Wang Zhen‐Bo , Wang Fuyi , Wan Li‐Jun , Guo Yu‐Guo 
Published: February 2023

AbstractIn overcoming the Li+ desolvation barrier for low‐temperature battery operation, a weakly‐solvated electrolyte based on carboxylate solvent has shown promises. In case of an organic‐anion‐enriched primary solvation sheath (PSS), we found that the electrolyte tends to form a highly swollen, unstable solid electrolyte interphase (SEI) that shows a high permeability to the electrolyte components, accounting for quickly declined electrochemical performance of graphite‐based anode. Here we proposed a facile strategy to tune the swelling property of SEI by introducing an inorganic anion switch into the PSS, via LiDFP co‐solute method. By forming a low‐swelling, Li3PO4‐rich SEI, the electrolyte‐consuming parasitic reactions and solvent co‐intercalation at graphite‐electrolyte interface are suppressed, which contributes to efficient Li+ transport, reversible Li+ (de)intercalation and stable structural evolution of graphite anode in high‐energy Li‐ion batteries at a low temperature of −20 °C.
Screening microbiota for effects on host tissues
Authors: Timm Andrea C. , Brensinger Bryan , Hart Meaghan , Timm Collin , Karig David 
Published: February 2023

AbstractThe assembly and function of microbial communities depends on many factors including the local environment and the metabolic properties of the colonizing organisms. Chemical communications or other secreted factors also play a role and are used by different microbial strains both cooperatively and competitively. The spectrum of microbial secretions have various effects on the microbe's respective hosts, both positive and negative. Thus, characterizing the roles of microbial community members and their secretions can yield key mechanistic insights into microbiome function and can lead to new intervention strategies. Focusing on the simple, yet important functional impact of toxicity, we quantify supernatant dosage responses with image data and examine the morphological effects of microbial secretions on skin‐associated host cells. Since the diversity of microbial communities, coupled with the multiplicity of host tissues requires scalable methods, we develop and demonstrate a microfluidic device that enables high‐content screening of microbial secretion effects on adherent cell types.
“The Parallel Dialogue”: Parental experience of their role in the relationship with their child's counsellor/psychotherapist
Authors: Taylor Helen 
Published: February 2023

AbstractThe parent–therapist relationship is a central consideration in child counselling and psychotherapy, particularly in private practice where parents are typically financially, emotionally and practically invested in the process. The relationship, which can be ambiguous and anxiety‐laden on both sides, has historically received scant attention in therapeutic discourse, leading to gaps in practitioner confidence and training. In this context, and seeking to centre parent voices, this study provides an interpretative phenomenological analysis of four mothers' experiences of their role in the relationship with their child's therapist. Key identified themes encompass parental expectation of involvement; the destabilising, disorienting nature of the relationship; the centrality of trust; and critical evaluations of value. Findings are discussed in relation to attachment theory and cultural expectations of parental responsibility. The study concludes that the relationship is a live and potent property with potential to impact the course of the intervention, and recommends that practitioners thoughtfully consider the potential benefits and drawbacks of meeting or frustrating parental involvement expectations.
TRIM29 promotes podocyte pyroptosis in diabetic nephropathy through the NF‐kB/NLRP3 inflammasome pathway
Authors: Xu Xiaohong , Qin Zihan , Zhang Ce , Mi Xia , Zhang Chi , Zhou Feihong , Wang Junsheng , Zhang Liexiang , Hua Fei 
Published: February 2023

AbstractDiabetic nephropathy (DN) is one of the most common complications of diabetes. Gradual loss of podocytes is a sign of DN and pyroptosis mechanistically correlates with podocyte injury in DN; however, the mechanism(s) involved remain unknown. Here we reveal that TRIM29 is overexpressed in high glucose (HG)‐treated murine podocytes cells and that TRIM29 silencing significantly inhibits podocyte damage due to HG treatment, as evidenced by lower desmin expression and greater nephrin expression. Additionally, flow cytometry analysis showed that TRIM29 silencing significantly inhibited HG treatment‐induced pyroptosis, which was confirmed by immunoblotting for NLRP3, active Caspase‐1, GSDMD‐N, and phosphorylated NF‐κB‐p65. Conversely, overexpression of TRIM29 could trigger pyroptosis that was attenuated by NF‐κB inhibition, indicating that TRIM29 promotes pyroptosis through the NF‐κB pathway. Mechanistic studies revealed that TRIM29 interacts with IκBα to mediate its ubiquitination‐dependent degradation, which in turn leads to NF‐κB activation. Taken together, our data demonstrate that TRIM29 can promote podocyte pyroptosis by activating the NF‐κB/NLRP3 pathway. Thus, TRIM29 represents a potentially novel therapeutic target that may also be clinically relevant in the management of DN.
Serial quantitative angiographic study of target lumen enlargement after drug‐coated balloon angioplasty for native coronary artery disease
Authors: Ueno Katsumi , Morita Norihiko , Kojima Yoshinobu , Takahashi Hiroshi , Esaki Masayasu , Kondo Hiroki , Ando Yu , Yamada Mayu , Kosokabe Tai 
Published: February 2023

AbstractBackgroundTarget lumen enlargement (TLE) or “late lumen enlargement” is often encountered after percutaneous coronary intervention (PCI) with drug‐coated balloons (DCB). To date, the prognosis of coronary arterial lesions with or without TLE has not been clearly elucidated.AimsThis study aimed to assess the long‐term prognosis of coronary arterial lesions with or without TLE observed within 1 year (early TLE) after DCB angioplasty using serial quantitative angiographic follow‐up.MethodsOne hundred and ninety‐three consecutive patients (de novo coronary arterial lesions, 251) who underwent follow‐up angiography within 1 year after DCB angioplasty (early follow‐up, median: 6 months) were retrospectively evaluated. Of these, 97 patients (125 lesions) also underwent angiography more than 1 year after DCB angioplasty (late follow‐up, median: 37 months). TLE was defined as an increase in minimal lumen diameter (MLD) after PCI at each follow‐up.ResultsEarly TLE was detected in 142 lesions (56.6%). Of these, 76 lesions were also evaluated at late follow‐up. TLE persisted even at late follow‐up in 67 of the 76 lesions (88.2%). An increase in MLD in early TLE (+) lesions was observed in the period between post‐PCI and early follow‐up (1.84 ± 0.06 vs. 2.12 ± 0.07 mm, p < 0.001) but not between early and late follow‐up (2.12 ± 0.07 vs. 2.16 ± 0.07 mm, p = 0.74). In contrast, 49 of 109 lesions without early TLE were evaluated at late follow‐up, of which 28 lesions (57.1%) showed TLE at late follow‐up. The MLD of early TLE (−) lesions (n = 49) significantly increased from early (1.63 ± 0.061 mm) to late follow‐up (1.84 ± 0.06 mm) (p < 0.001). No aneurysms were found in any of these cases.ConclusionEarly TLE was observed in more than half of the lesions, with the majority remaining at late follow‐up. Alternatively, half of the lesions without early TLE showed late TLE, occurring biphasically after DCB angioplasty.
A trial of topiramate for patients with hereditary spinocerebellar ataxia
Authors: Miura Shiroh , Sawada Ryusuke , Yorita Akiko , Kida Hiroshi , Kamada Takashi , Yamanishi Yoshihiro 
Published: February 2023

AbstractIn an open pilot trial, six patients with various hereditary forms of spinocerebellar ataxia (SCA) were assigned to topiramate (50 mg/day) for 24 weeks. Four patients completed the protocol without adverse events. Of these four patients, topiramate was effective for three patients. Some patients with SCA could respond to treatment with topiramate.
Surface Studies on the Energy Release of the MOST System 2‐Carbethoxy‐3‐Phenyl‐Norbornadiene/Quadricyclane (PENBD/PEQC) on Pt(111) and Ni(111)
Authors: Hemauer Felix , Schwaab Valentin , Freiberger Eva Marie , Waleska Natalie J. , Leng Andreas , Weiß Cornelius , Steinhauer Johann , Düll Fabian , Bachmann Philipp , Hirsch Andreas , Steinrück Hans‐Peter , Papp Christian 
Published: February 2023

AbstractNovel energy‐storage solutions are necessary for the transition from fossil to renewable energy sources. Auspicious candidates are so‐called molecular solar thermal (MOST) systems. In our study, we investigate the surface chemistry of a derivatized norbornadiene/quadricyclane molecule pair. By using suitable push–pull substituents, a bathochromic shift of the absorption onset is achieved, allowing a greater overlap with the solar spectrum. Specifically, the adsorption and thermally induced reactions of 2‐carbethoxy‐3‐phenyl‐norbornadiene/quadricyclane are assessed on Pt(111) and Ni(111) as model catalyst surfaces by synchrotron radiation‐based X‐ray photoelectron spectroscopy (XPS). Comparison of the respective XP spectra enables the distinction of the energy‐rich molecule from its energy‐lean counterpart and allows qualitative information on the adsorption motifs to be derived. Monitoring the quantitative cycloreversion between 140 and 230 K spectroscopically demonstrates the release of the stored energy to be successfully triggered on Pt(111). Heating to above 300 K leads to fragmentation of the molecular framework. On Ni(111), no conversion of the energy‐rich compound takes place. The individual decomposition pathways of the two isomers begin at 160 and 180 K, respectively. Pronounced desorption of almost the entire surface coverage only occurs for the energy‐lean molecule on Ni(111) above 280 K; this suggests weakly bound species. The correlation between adsorption motif and desorption behavior is important for applications of MOST systems in heterogeneously catalyzed processes.
JAK1/2 inhibitor ruxolitinib promotes the expansion and suppressive action of polymorphonuclear myeloid‐derived suppressor cells via the JAK/STAT and ROS‐MAPK/NF‐κB signalling pathways in acute graft‐versus‐host disease
Authors: Cao Yigeng , Wang Jiali , Jiang Shan , Lyu Mengnan , Zhao Fei , Liu Jia , Wang Mingyang , Pei Xiaolei , Zhai Weihua , Feng Xiaoming , Feng Sizhou , Han Mingzhe , Xu Yuanfu , Jiang Erlie 
Published: February 2023

AbstractObjectivesRuxolitinib, a Janus kinase (JAK) 1/2 inhibitor, demonstrates efficacy for treating steroid‐resistant acute graft‐versus‐host disease (SR‐aGVHD) following allogeneic stem cell transplantation (allo‐HSCT). Myeloid‐derived suppressor cells (MDSCs) have a protective effect on aGVHD via suppressing T cell function. However, the precise features and mechanism of JAK inhibitor‐mediated immune modulation on MDSCs subsets remain poorly understood.MethodsA total of 74 SR‐aGVHD patients treated with allo‐HSCT and ruxolitinib were enrolled in the present study. The alterations of MDSC and regulatory T cell (Treg) populations were monitored during ruxolitinib treatment in responders and nonresponders. A mouse model of aGVHD was used to evaluate the immunosuppressive activity of MDSCs and related signalling pathways in response to ruxolitinib administration in vivo and in vitro.ResultsPatients with SR‐aGVHD who received ruxolitinib treatment achieved satisfactory outcomes. Elevation proportions of MDSCs before treatment, especially polymorphonuclear‐MDSCs (PMN‐MDSCs) were better to reflect the response to ruxolitinib than those in Tregs. In the mouse model of aGVHD, the administration of ruxolitinib resulted in the expansion and functional enhancement of PMN‐MDSCs and the effects could be partially reversed by an anti‐Gr‐1 antibody in vivo. Ruxolitinib treatment significantly elevated the suppressive function of PMN‐MDSCs through reactive oxygen species (ROS) production by Nox2 upregulation as well as bypassing the activated MAPK/NF‐κB signalling pathway. Additionally, ex vivo experiments demonstrated that ruxolitinib prevented the differentiation of mature myeloid cells and promoted the accumulation of MDSCs by inhibiting STAT5.ConclusionsRuxolitinib enhances PMN‐MDSCs functions through JAK/STAT and ROS‐MAPK/NF‐κB signalling pathways. Monitoring frequencies and functions of MDSCs can help evaluate treatment responses to ruxolitinib.
Investigation of the potential mutagenicity of ethyl tertiary‐butyl ether in the tumor target tissue using transgenic Big Blue Fischer 344 rats following whole body inhalation exposure
Authors: Gollapudi B. Bhaskar , Rushton Erik K. 
Published: February 2023

AbstractEthyl tertiary‐butyl ether (ETBE) is a fuel oxygenate used for the efficiency of motor vehicle fuels and their octane ratings. ETBE has been reported to induce liver adenomas in male rats in a 2‐year bioassay at the highest inhalation concentration tested of 5000 ppm. To investigate the potential mutagenicity of ETBE in the liver, male Big Blue Fischer 344 rats were exposed for 28 consecutive days (6 h/day) to 0, 500, 1500, and 5000 ppm ETBE. The treated rats were sacrificed 3 days post‐exposure and the frequencies of cII mutants were evaluated in the liver and bone marrow tissues. The mutant frequency (MF) of the liver in the negative control group was 36.3 × 10−6 and this value was not significantly different in ETBE‐exposed animals (39.4, 37.3, and 45.9 × 10−6 in 500, 1500, and 5000 ppm groups, respectively). In the bone marrow, the mean MF in the negative control was 32.9 × 10−6 which was not different from the means of the exposed groups (33.8, 22.6, and 32.0 × 10−6 for groups exposed to 500, 1500 and 5000 ppm, respectively). These data, along with consistent negative response reported in the literature for other apical genotoxicity endpoints informs that mutagenicity is not likely the initial key event in the mode of action for ETBE‐induced hepatocarcinogenesis in the rat.
Lack of hydroxyurea‐associated mutagenesis in pediatric sickle cell disease patients
Authors: Torous Dorothea K. , Avlasevich Svetlana , Bemis Jeffrey C. , Howard Thad , Ware Russell E. , Fung Chunkit , Chen Yuhchyau , Sahsrabudhe Deepak , MacGregor James T. , Dertinger Stephen D. 
Published: February 2023

AbstractHydroxyurea is approved for treating children and adults with sickle cell anemia (SCA). Despite its proven efficacy, concerns remain about its mutagenic and carcinogenic potential that hamper its widespread use. Cell culture‐ and animal‐based investigations indicate that hydroxyurea's genotoxic effects are due to indirect clastogenicity in select cell types when high dose and time thresholds are exceeded (reviewed by Ware & Dertinger, 2021). The current study extends these preclinical observations to pediatric patients receiving hydroxyurea for treatment of SCA. First, proof‐of‐principle experiments with testicular cancer patients exposed to a cisplatin‐based regimen validated the ability of flow cytometric blood‐based micronucleated reticulocyte (MN‐RET) andPIG‐Amutant reticulocyte (MUT RET) assays to detect clastogenicity and gene mutations, respectively. Second, these biomarkers were measured in a cross‐sectional study with 26 SCA patients receiving hydroxyurea and 13 SCA patients without exposure. Finally, a prospective study was conducted with 10 SCA patients using pretreatment blood samples and after 6 or 12 months of therapy. Cancer patients exposed to cisplatin exhibited increased MN‐RET within days of exposure, while the MUT RET endpoint required more time to reach maximal levels. In SCA patients, hydroxyurea induced MN‐RET in both the cross‐sectional and prospective studies. However, no evidence ofPIG‐Agene mutation was found in hydroxyurea‐treated children, despite the fact that the two assays use the same rapidly‐dividing, highly‐exposed cell type. Collectively, these results reinforce the complementary nature of MN‐RET and MUT RET biomarkers, and indicate that hydroxyurea can be clastogenic but was not mutagenic in young patients with SCA.
Life‐cycle risk assessment of building portfolios subjected to tsunamis under non‐stationary sea‐level rise based on a compound renewal process
Authors: Alhamid Abdul Kadir , Akiyama Mitsuyoshi , Aoki Koki , Koshimura Shunichi , Frangopol Dan M. 
Published: February 2023

AbstractThe immense impacts of tsunamis can inflict substantial damage on coastal infrastructure systems during their lifetime and lead to considerable economic loss. However, with the increasing intensity and variability of sea‐level rise due to climate change, evaluations of the life‐cycle tsunami risk associated with cumulative loss have become increasingly complex since tsunami hazards are time‐dependent. In addition, the number of earthquake events and the corresponding arrival times are substantially uncertain. Therefore, an accurate life‐cycle tsunami risk assessment methodology should be established to appropriately develop disaster mitigation measures. This paper provides a novel life‐cycle risk assessment of building portfolios subjected to tsunami hazards under non‐stationary sea‐level rise effects due to climate change. The cumulative loss of a building portfolio is evaluated through a compound renewal process based on earthquake interarrival time uncertainties and time‐dependent risk. The earthquake interarrival times are modeled using a non‐Poisson process based on historical data. Tsunami hazard curves that consider the effects of sea‐level rise, estimated based on climate models, are obtained with tsunami propagation analysis. The time‐variant annual risk is estimated based on reliability and building unit loss. Finally, a numerical procedure is proposed to estimate the life‐cycle tsunami risk of building portfolios. An illustrative example is provided by applying the framework to several municipalities in the Kochi Prefecture of Japan to assess the effects of climate change on the life‐cycle tsunami risk.
Design optimization of a coal seam annular air reverse circulation bit
Authors: Chen Demin , Qu Baohua , Long Wei , Li Yanyan 
Published: February 2023

AbstractReverse circulation (RC) drilling technology enables the rapid acquisition of coal seam samples, which is crucial in accurately measuring gas content. In addition, the design of the drill bit plays a key role in RC sampling. In this study, the turbulence model and simulation method applied during the RC drilling process is analyzed, and an annular jet flow bit is developed. An experimental laboratory setup is used to simulate the RC performance of the proposed drill bit, based on which an orthogonal design simulation of the structural parameters of the drilling bit studies was performed to investigate the effects of the RC drilling process. The experimental results show that annular jet flow moving up the central channel wall of the bit is conducive to the suction of annular airflow and results in the strong flow field created by the center channel of the bit generating negative pressure in the center channel of the bit, a comparison of the computational fluid dynamics data on negative pressure and suction rate shows that the annular jet flow RC bit is suitable for use in RC drilling.