bluuebunny/crossref_metadata_2025_split huggingface dataset:
La trastienda de los inicios en la investigación social: elementos característicos.
Authors: De Gracia Palomera Daniel 
Published: June 2023

Esta investigación, enmarcada en la corriente de la trastienda histórico-biográfica de la investigación social, tiene la intención de identificar y analizar elementos clave en los itinerarios del oficio de la investigación social. A partir de un análisis comparativo distante inspirado por Valles (2009) y Glaser y Strauss (1973) de 34 entrevistas a investigadores e investigadoras sociales y 14 entrevistas de archivo a artistas visuales, se han logrado identificar siete elementos clave en el acceso y las etapas tempranas de los itinerarios en el oficio de la investigación social: la formación no orientada a la práctica profesional, la docencia como elemento de importancia, la combinación del desarrollo profesional con empleos en otros sectores, la importancia del apoyo familiar, la importancia de las redes de contactos, las becas, premios y concursos como corrientes que aceleran trayectorias y el dilema entre probar el ámbito privado o mantener continuar en la academia.
PUBLIC GOVERNANCE - A SYSTEMIC PUBLIC PHENOMENON
Authors: Gayevaya Oleksandra , Garyaeva Ganna , Lysenko Iryna 
Published: June 2023

In the article it is investigated how the formation of civil society in the country is taken place, what scientific rethinking is needed to determine the place of power in public administration. The way of formation of public administration, political system, state institutions from the period of the Old Russian state to the present is traced.The originations of problems of theory and practice of social management and policy of the Ancient world in the formation of states in the world are analyzed. The value of the state as a philosophical and legal theory and practice of organization of political power and management of society is pointed out. It is elucidated the advocating of ideasof the rule of law, the requirements to observe legal justice, the contractual concepts of the state. The essence of management in which the primary component is the person, its conscious activity is exposed. Two approaches to understanding of the content of public administration are highlighted: "American" and "European". Different viewsof scientists on the definition of "public administration" are analyzed. The stages of evolution of the managerial (managerial) school are considered and the term "social management" is noted. Different approaches to this "mechanism of influence" on society are highlighted. It is defined two approaches to management: "managerialism"and the theory of "scientific management of society". The meaning of the term "administration" is exposed and its interpretation from different points of view. It is pointed out the consideration of this concept in foreign practice, and, accordingly, in Ukraine. The concept of "public administration" is highlighted, and the "mechanism" of its action is indicated. It is determined the subjects of public administration such as: executive authorities, their staff, officials and office workers; executive bodies and officials of local self-government, officials and officials of executive bodies of local self-government. The characteristic features of the post-Soviet public administration transformation into public administration are highlighted
Access, Interest and Equity Considerations for Virtual Global Health Activities During the COVID-19 Pandemic: Quantitative Analysis of a Mixed Methods Study.
Authors: Umphrey Lisa , Beck Alyssa , Zhou Shuo , Kagoya Enid Kawala , Paasi George , Coria Alexandra , Evert Jessica , Haque Marina , Rule Amy , Lamb Molly 
Published: June 2023

Abstract

Background:Global health activities reduce health disparities by promoting medical education, professional development, and resource sharing between high- and low- to middle-income countries. Virtual global health activities facilitated continuity and bidirectionality in global health during the COVID-19 pandemic, but while virtual engagement holds potential for promoting equity within partnerships, research on equitable access to and interest in virtual global health activities is limited.Methods:We conducted a cross-sectional, online, mixed-methods survey from January to February 2022 examining access to virtual activities before and during the pandemic across resource settings. Eligible participants were participants or facilitators of global health activities. Closed- and open-ended questions elicited participants’ access to and interest in virtual global health engagement.Results:We analyzed surveys from 265 respondents representing 45 countries (high-income 57.0% vs. low- to middle-income 43.0%). High-income country respondents had significantly more access to global health funding through their own organization and more flexibility for using funds. More respondents from low- to middle-income countries versus high-income countries reported loss of more types of in-person access due to the pandemic at their own institutions, while more respondents from high-income countries versus low- to middle-income countries reported loss of in-person activities at another institution. While all respondents reported an increase in access to virtual global health activities during the pandemic, more respondents from low- to middle-income countries versus high-income countries gained virtual access more often through another organization. There were significant differences and trends between respondent groups in different resource environments in terms of accessibility to and interest in different virtual global health activities, both during and after the pandemic. Qualitative results are presented in another manuscript.Conclusions:Our results highlight the need to examine accessibility to virtual global health activities within partnerships between high- and low- to middle-income countries. While virtual activities may bridge existing gaps in global health education and partnerships, further study on priorities and agenda setting for such initiatives, with special attention to power dynamics and structural barriers, are necessary to ensure meaningful virtual global health engagement moving forward.
Obesity-dependent increase in RalA activity disrupts mitochondrial dynamics in white adipocytes
Authors: xia Wenmin , Veeragandham Preethi , Cao Yu , Xu Yayun , Rhyne Torrey , Qian Jiaxin , Hung Chao-Wei , Zhao Peng , Jones Ying , Gao Hui , Liddle Christopher , Yu Ruth , Downes Michael , Evans Ronald , Ryden Mikael , Wabitsch Martin , Reilly Shannon , Huang Jianfeng , Saltiel Alan 
Published: June 2023

Abstract
Mitochondrial dysfunction is a characteristic trait of human and rodent obesity, insulin resistance, and fatty liver disease. Here we report that mitochondria undergo fragmentation and reduced oxidative capacity specifically in inguinal white adipose tissue after feeding mice high fat diet (HFD) by a process dependent on the small GTPase RalA. RalA expression and activity are increased in white adipocytes from mice fed HFD. Targeted deletion of Rala in white adipocytes prevents the obesity-induced fragmentation of mitochondria and produces mice resistant to HFD-induced weight gain via increased fatty acid oxidation. As a result, these mice also exhibit improved glucose tolerance and liver function. In vitro mechanistic studies revealed that RalA suppresses mitochondrial oxidative function in adipocytes by increasing fission through reversing the protein kinase A-catalyzed inhibitory Ser637phosphorylation of the mitochondrial fission protein Drp1. Active RalA recruits protein phosphatase 2A (PP2Aa) to specifically dephosphorylate this inhibitory site on Drp1, activating the protein, thus increasing mitochondrial fission. Adipose tissue expression of the human homolog of Drp1, DNML1, is positively correlated with obesity and insulin resistance in patients. Thus, chronic activation of RalA plays a key role in repressing energy expenditure in obese adipose tissue by shifting the balance of mitochondrial dynamics towards excessive fission, contributing to weight gain and related metabolic dysfunction.
Mitochondria Targeted AuCu@Ce6-TPP nanoparticles Alleviating Cancer Hypoxia for Enhanced Photodynamic Therapy
Authors: You Zhu , Li Jiangsheng , Zhai Shiyi , Zhao Junxuan , Lu Kuangda 
Published: June 2023

Abstract

Photodynamic therapy (PDT) has advanced rapidly in the treatment of cancer due to its low resistance and reduced adverse effects. However, hypoxia is one of the most significant obstacles that limit the therapeutic effect and clinical transformation of this noninvasive treatment. Numerous studies have been conducted on alleviating hypoxia to improve antitumor effect, but comprehensive nanosystems that simultaneously overcome hypoxia and other severely limitation of PDT are seldom reported. Here we report a multifunctional nanosystem AuCu@Ce6-TPP (ACCT) that alleviates hypoxia and targets mitochondria to enhance PDT of cancer. Mercaptoethyl-triphenylphosphonium and mercapto chlorin e6 were conjugated to AuCu nanoparticles and thus Ce6 photosensitized 1O2 can cause direct damage to mitochondria, leading to mitochondrial apoptosis Copper can catalyze hydrogen peroxide degradation to alleviate hypoxia, whereas gold can consume glutathione to elevate the oxidative stress. ACCT-sensitized PDT leads to tumor growth inhibition rate of 92.8% on 4T1 tumor-bearing mice model. This work therefore demonstrates a potential solution to enhance PDT on hypoxic tumors.
A study of factors influencing college students' behavior in participating in digital training
Authors: HUANG CONG , WEN GE , LIU MING DONG 
Published: June 2023

Abstract
The participation of university students in digital training will not only improve their digital literacy and career development, but will also support the smooth implementation of the Digital China Strategy.Based on TAM and TPB theories,the survey data of university students in Chengdu, Chongqing, Guangzhou and Shanghai were used to analyse their willingness and behaviour to participate in training, and structural equation modelling was used to study their influencing factors.The results show that university students' willingness to participate in training and their training behaviour are generally positive, with mean values of 3.05 and 3.06 respectively; university students' willingness to participate in digital training has a significant positive impact on their participation behaviour.Subjective norms,behavioural attitudes, perceived ease of use and perceived usefulness have a significant positive impact on university students' willingness to participate in digital learning, with subjective norms having the greatest impact on willingness to participate, followed by perceived ease of use and perceived usefulness.Subjective norms have the greatest influence on intention to attend training, followed by perceived ease of use and perceived usefulness, while behavioural attitudes have the least influence.Therefore, it is necessary to pay attention to the training needs of university students and promote their career development; the administration should pay attention to the formulation of relevant policies to guide them and create a training environment; universities and related educational institutions should enrich the training content.Multi-dimensional and multi-subject promotion of university students' willingness to participate in digital training and guiding them to actively engage in training behaviour.
A composite purification method for ultra-low iron content zirconium sulfate solution
Authors: zhao lang , song kun , deng minghong , hu meilong , Xin Yuntao 
Published: June 2023

Abstract

It is critical to remove Fe removal from the titanium dioxide coating solution. In this study, we combined potassium ferricyanide precipitation with ultrafiltration for deep Fe removal. The effects of the potassium ferrocyanide dosage, reaction temperature, reaction time, stirring speed, and ultrafiltration membrane specifications on Fe removal were systematically studied. Furthermore, the experimental conditions were optimized to achieve the lowest Fe content of 8.1 mg/L in the solution. The size distribution and zeta potential of the precipitate particles were determined, and the results revealed that the effective diameter of the particles was 16.581 μm and the zeta potential of the surface groups was negative. A cationic flocculant was added to eliminate the static repulsion between precipitate particles and promote their growth. The Fe content reached 3.8 mg/L after 0.1 mL of flocculant solution was added to the solution. Lastly, the Fe removal mechanism was determined.
Cross-lagged Analysis of Rumination and Social Anxiety Among China College Students
Authors: Wu Peibo , Cao Keyan , Feng Wenjing , Lv Shuai 
Published: June 2023

Abstract
Background
Social anxiety, widely prevalent amongst Chinese college students, poses a significant barrier to their holistic psychological and physiological development. Despite numerous cross-sectional studies examining the relationship between rumination and social anxiety, a gap remains in understanding their interplay over time. This longitudinal study aimed to explore and analyze the intricate interrelation between these two factors, with the ultimate goal of informing the development of effective mental health education interventions for university students.
Methods
Using the Ruminative Responses Scale (RRS) and the Interaction Anxiousness Scale (IAS), a two-stage longitudinal follow-up study of 392 college students from three universities in Henan Province was conducted over a six-month period (October 2022 to March 2023), using a cross-lagged model (The cross-lagged model was used to explore the correlation between rumination and social anxiety. The results of the correlation analysis showed that rumination was positively associated with social anxiety at both time points (r = 0.18,0.12, p < 0.01).
Results
Cross-lagged regression analyses revealed that the predictive effect of the first measure (T1) rumination on the second measure (T2) rumination was statistically significant (β = 0.32, p < 0.01). the predictive effect of T1 social anxiety on T2 social anxiety was statistically significant (β = 0.65, p < 0.01), the predictive effect of T1 rumination on T2 social anxiety was statistically significance (β = 0.33, p < 0.01) and the prediction of T1 social anxiety on T2 rumination was statistically significant (β = 0.28, p < 0.01).
Conclusion
Rumination and social anxiety in college students are mutually predictive of each other, and interventions by educators in either area of ruminant thinking and social anxiety will interrupt the vicious cycle between ruminant thinking and social anxiety.
Identification and validation of ferroptosis related genes in prostate cancer cells under erastin exposure
Authors: Wu Fan , Huang Fei , Jiang Nili , Su Jinfeng , Yao Siyi , Liang Boying , Li Wen , Yan Tengyue , Zhou Sufang , Zhou Qingniao 
Published: June 2023

Abstract
Few studies are focusing on the mechanism of erastin acts on prostate cancer(PCa) cells, and essential ferroptosis-related genes (FRGs) that can be PCa treatment targets are rarely known. In the current study, in vitro assays were performed to evaluate the ferroptotic levels of PCa cells under erastin treatment. RNA-seq was used to measure the expression of differentially expressed genes (DEGs) in erastin-induced PCa cells. A series of bioinformatic analyses were applied to analyze the pathways, module, transcription factors, and expression levels of DEGs. Erastin inhibited the expression of ferroptosis marker SLC7A11 and cell survivability in both PCa cells. After treatment with erastin, the concentration level of MDA and Fe2+ significantly increased, whereas GSH and GSSG significantly decreased in PCa cells. A total of 295 overlapping DEGs were screened and identified in two cells under erastin exposure and significantly enriched for association with some pathways. The expression levels of four hub FRGs, including TMEFF2, CLU, NRXN3, and UNC5B, were significantly different in PCa and normal tissues. TMEFF2 was the gene co-expressed with SLC7A11 and GPX4. In both PCa cells, the expression levels of SLC7A11 and cell growth were inhibited after the knockdown of TMEFF2. The concentration of Fe2+ significantly increased in two TMEFF2 downregulated cells. In conclusion, FRGs and their correlations with ferroptosis in PCa were identified and validated. Our results showed that these FRGs play a crucial role in PCa, and offered the potential therapeutic target genes for the investigation and treatment of PCa.
Identification of ferroptosis-related diagnostic biomarkers in ischemic cardiomyopathy
Authors: Ma Guizhou , Zhou Linjie , Xu Ronghe , Wang Ying , Cai Zhixiong 
Published: June 2023

Abstract
Background:
Ischemic cardiomyopathy (ICM), the frequently observed secondary cardiomyopathy, is a major factor leading to global mortality. Ferroptosis is a type of iron-dependent programmed cell death different from apoptosis or additional programmed cell death types, identified as the major cell death type of cardiomyocytes. Consequently, the present study focused on the identification of ferroptosis-related genes (FRGs) and determining their value in diagnosing ICM, thus, assisting in detecting and treating ICM.
Methods:
This study collected gene expression profiles for ventricular myocardium specimens in ICM cases and normal participants from the gene expression omnibus database. First, ferroptosis-related differentially expressed genes (FRDEGs) were detected in ICM. Then, a protein-protein interaction (PPI) network related to FRDEGs was constructed through PPI network analysis, followed by the identification of the key network and hub genes whose expression was analyzed and assessed using receiver operating characteristic (ROC) curve analysis and verified in the external validation set. Finally, hub genes were subject to single-gene GSEA pathway enrichment, targeted drug prediction, construction of miRNA as well as transcription factor regulatory network.
Results:
A total of 1396 DEGs were detected, among which 711 showed up-regulation, whereas 685 displayed down-regulation in patients with ICM compared with healthy controls. After overlapping with FRGs, 39 FRDEGs were obtained. Based on the gene Ontology function together with the Kyoto encyclopedia of genes and genomes analysis, the aforementioned genes were mostly associated with starvation, cellular extracellular stimulus, and cellular starvation responses, peroxisome proliferators-activated receptors signaling pathway, human cytomegalovirus infection, and hepatitis C. Eight hub genes were obtained from the PPI network related to FRDEGs. Hub gene expression was down-regulated in the ICM. ROC curves showed that the area under the curve of activating transcription factor 4 (ATF4), signal transducers and activators of transcription 3 (STAT3), CCAAT enhancer binding protein gamma, X-box binding protein 1 (XBP1), and eukaryotic translation initiation factor 2 subunit alpha was greater than 0.7. After verification in the external dataset, XBP1, ATF4, and STAT3 were screened as the diagnostic genes for ICM.
Conclusion:
This study provided the first bioinformatics analysis of FRGs and their diagnostic value in ICM. The XBP1, STAT3, and ATF4 were identified as potential diagnostic genes of ICM. Thus, these genes may provide novel markers or targets to diagnose and treat ICM.
Acaridical activity of plant extracts to control Date palm fruit dust mite Oligonychus afrasiaticus (McGregor) (Acari Tetranchidae)
Authors: Ali Hazim M. , Fhaid Khalid A. , Awad Khairullah M. 
Published: June 2023

Abstract
This study aimed to determine the variables that influence the mortality rate of Oligonychus afrasiaticus (McGregor) (Acari Tetranchidae) dust mites and to explore potential control options for this pest. The important variables that were examined at included plant species, extraction method, concentration, and time. The findings indicated noteworthy impacts of these variables on the mortality rates of dust mites. The mortality rates of dust mites were significantly affected by the type of plant species (p < 0.01). The highest mortality rates were observed with Cymbopogon citratus, whereas there was no significant variation between Vitexm agnus-castus and Melilotus officinalis. The extraction method was Influential (p < 0.01), with ethanol extract performing better than aqueous and hexane extracts in terms of efficacy. Aqueous extraction had a lower efficacy than hexane extraction. The concentration of plant extract considerably affected the mortality rates of dust mites (p < 0.01). increased concentrations led to significantly increased mortality rates, demonstrating a concentration-dependent impact. Dust mite mortality rates were also affected by exposure duration (p 0.01). When the exposure period was increased, the mortality rate increased considerably. Significant differences in mortality rates have been observed for each time period (6, 12, 24, and 48 hours). These findings emphasize the importance of selecting appropriate plant species, utilizing effective extraction methods, optimizing concentration levels, and considering exposure duration for designing efficient dust mite control strategies. Cymbopogon citratus, especially when extracted with ethanol and applied at higher concentrations, has the potential to be a natural dust mite control treatment.
Comparison of effectiveness and safety of Da Vinci robot’s “3+1” and “4+1” modes of treatment for colorectal cancer
Authors: Wang Huaiwen , Wu Yuanhao , Huang Ping , Chen Weijia , Wang Zhenfen , Wang Yuna 
Published: June 2023

Abstract

ObjectiveTo compare the effectiveness of the Da Vinci Surgical Robot System (DSRS) “3 + 1” and “4 + 1” models for colorectal cancer (CRC).MethodsA total of 107 patients with CRC admitted to our hospital from February 2021 to May 2022 were selected for the retrospective analysis. Of these, 57 patients underwent the DSRS “4 + 1” model (control group), while the rest 50 underwent the DSRS “3 + 1” model (research group). The operation time, intraoperative bleeding, number of lymph nodes detected, time of first postoperative urinary catheter removal, time of first feeding, time of first venting and hospitalization were compared between the two groups. The changes of white blood cell (WBC) and C-reactive protein (CRP) levels before and after surgery were detected, and patients’ adverse effects and treatment costs between surgery and hospital discharge were counted. The Self-Rating Anxiety Scale (SAS) and the Self-Rating Depression Scale (SDS) were used to assess the psychological state of the patients.ResultsThere was no difference in operative time, intraoperative bleeding, and number of lymph nodes detected between both groups (P > 0.05), while time to first postoperative urinary catheter removal, time to first feeding, time to first venting, length of stay (LOS), postoperative inflammatory factor levels, incidence of adverse events, and treatment costs were all lower in the research group than in the control group (P < 0.05). SAS and SDS scores decreased after treatment in both groups, but the decrease was more obvious in the research group (P < 0.05).ConclusionBoth DSRS “4 + 1” and “3 + 1” modes have better treatment effects for CRC. But the “3 + 1” mode has higher safety and lower treatment cost, which can significantly improve the postoperative recovery process of patients and is more worthy to be promoted in clinical practice.