bluuebunny/crossref_metadata_2025_split huggingface dataset:
Current progress in growth factors and extracellular vesicles in tendon healing
Authors: Wang Yufeng , Li Jin 
Published: June 2023

AbstractTendon injury healing is a complex process that involves the participation of a significant number of molecules and cells, including growth factors molecules in a key role. Numerous studies have demonstrated the function of growth factors in tendon healing, and the recent emergence of EV has also provided a new visual field for promoting tendon healing. This review examines the tendon structure, growth, and development, as well as the physiological process of its healing after injury. The review assesses the role of six substances in tendon healing: insulin‐like growth factor‐I (IGF‐I), transforming growth factor β (TGFβ), vascular endothelial growth factor (VEGF), platelet‐derived growth factor (PDGF), basic fibroblast growth factor (bFGF), and EV. Different growth factors are active at various stages of healing and exhibit separate physiological activities. IGF‐1 is expressed immediately after injury and stimulates the mitosis of various cells while suppressing the response to inflammation. VEGF, which is also active immediately after injury, accelerates local metabolism by promoting vascular network formation and positively impacts the activities of other growth factors. However, VEGF's protracted action could be harmful to tendon healing. PDGF, the earliest discovered cytokine to influence tendon healing, has a powerful cell chemotaxis and promotes cell proliferation, but it can equally accelerate the response to inflammation and relieve local adhesions. Also useful for relieving tendon adhesion is TGF‐ β, which is active almost during the entire phase of tendon healing. As a powerful active substance, in addition to its participation in the field of cardiovascular and cerebrovascular vessels, tumour and chronic wounds, TGF‐ β reportedly plays a role in promoting cell proliferation, activating growth factors, and inhibiting inflammatory response during tendon healing.
Role and mechanism of Circ‐PDE7B in the formation of keloid
Authors: Tang Yueling , Li Xiaojing 
Published: June 2023

AbstractThe excessive proliferation of keloid fibroblasts is one of the important reasons leading to the formation of keloids. Circular RNA (circRNA) is an important regulator that regulates the biological functions of cells. However, the role and mechanism of circ‐PDE7B in keloid formation have not been studied yet. QRT‐PCR was used to detect the circ‐PDE7B, miR‐331‐3p and cyclin‐dependent kinase 6 (CDK6) expression. The biological functions of keloid fibroblasts were determined by MTT assay, flow cytometry, transwell assay and wound healing assay. Western blot analysis was used to measure the protein levels of extracellular matrix (ECM) markers and CDK6. The interaction between miR‐331‐3p and circ‐PDE7B or CDK6 was confirmed by dual‐luciferase reporter assay and RIP assay. Circ‐PDE7B was found to be upregulated in keloid tissues and fibroblasts. Downregulation of circ‐PDE7B could suppress the proliferation, invasion, migration, ECM accumulation and accelerate the apoptosis of keloid fibroblasts. Circ‐PDE7B could serve as a sponge of miR‐331‐3p, and the regulation of silenced circ‐PDE7B on the biological functions of keloid fibroblasts could be abolished by miR‐331‐3p inhibitor. Additionally, CDK6 was a target of miR‐331‐3p, and its overexpression could reverse the negative regulation of miR‐331‐3p on the biological functions of keloid fibroblasts. Circ‐PDE7B sponged miR‐331‐3p to positively regulate CDK6 expression. Taken together, circ‐PDE7B promoted the proliferation, invasion, migration and ECM accumulation of keloid fibroblasts by regulating the miR‐331‐3p/CDK6 axis, suggesting that circ‐PDE7B might be a potential target for keloid treatment.
Quality registry improves the data of chronic ulcers: Validation of Tampere Wound Registry
Authors: Pöyry Anna , Kimpimäki Teija , Kaartinen Ilkka , Salmi Teea T. 
Published: June 2023

AbstractQuality registries are potential tools for improving health care documentation, but the quality and completeness of each registry should be ensured. This study aimed to evaluate the completion rate (completeness) and accuracy of data, first contact‐to‐registration time (timeliness), and case coverage of the Tampere Wound Registry (TWR) to assess whether it can be reliably used in clinical practice and for research purposes. Data from all 923 patients registered in the TWR between 5 June 2018 and 31 December 2020 were included in the analysis of data completeness, while data accuracy, timeliness and case coverage were analysed in those registered during the year 2020. In all analyses values over 80% were considered good and values over 90% excellent. The study showed that the overall completeness of the TWR was 81% and overall accuracy was 93%. Timeliness achieved 86% within the first 24 h, and case coverage was found to be 91%. When completion of seven selected variables was compared between TWR and patient medical records, the TWR was found to be more complete in five out of seven variables. In conclusion, the TWR proved to be a reliable tool for health care documentation and an even more reliable data source than patient medical records.
Microwave hybrid and conventional sintering of Al2O3 and Al2O3/ZrO2 multilayers fabricated by aqueous tape casting
Authors: Khalid Muhammad Waqas , Park SangCheol , Kim InYeong , Hussain Javid , Hussain Amjad , Ali Ammad , Kim Bum Sung , Lee Bin 
Published: June 2023

AbstractIn this study, microwave hybrid sintering and conventional sintering of Al2O3‐ and Al2O3/ZrO2‐laminated structures fabricated via aqueous tape casting were investigated. A combination of process temperature control rings and thermocouples was used to measure the sample surface temperatures more accurately. Microwave hybrid sintering caused higher densification and resulted in higher hardness in Al2O3 and Al2O3/ZrO2 than in their conventionally sintered counterparts. The flexural strength of microwave‐hybrid‐sintered Al2O3/ZrO2 was 70.9% higher than that of the conventionally sintered composite, despite a lower sintering temperature. The fracture toughness of the microwave‐hybrid‐sintered Al2O3 increased remarkably by 107.8% despite a decrease in the relative density when only 3 wt.% t‐ZrO2 was added. The fracture toughness of the microwave‐hybrid‐sintered Al2O3/ZrO2 was significantly higher (247.7%) than that of the conventionally sintered composite. A higher particle coordination and voids elimination due to the tape casting and the lamination processes, the microwave effect, the stress‐induced martensitic phase transformation, and the grain refinement phenomenon are regarded as the main reasons for the mentioned outcomes.
Development of a small‐size processing line for production of safflower oil
Authors: Mursalykova Maigul , Iskakov Bauyrzhan , Kakimov Mukhtarbek , Zhumadilova Gulmira , Shulenova Assem 
Published: June 2023

AbstractThere is growing interest in exploring new types of cultivated plants that offer unique health benefits. Safflower is a promising plant nutrition resource that has gained popularity in Kazakhstan and worldwide. However, one of the pressing issues is improving the consumption pattern of food products, including vitamins and microelements. This article aims to develop a small‐scale processing line for safflower oil production in small enterprises of the cereal‐processing industry. The primary focus is on purifying safflower from impurities and husks, as well as compressing and centrifuging the oil raw material for high‐quality and biologically valuable product. The authors developed a processing line consisting of a sheller‐compress and a centrifuge of original constructions for separating husks from the kernel and compressing and centrifuging the oil raw material. The process combines husking, compressing, filtration, and sedimentation to ensure primary purification of plant oils and the removal of mechanical impurities. The production of safflower oil has become an urgent task due to its rich composition of vitamins and phospholipids. The newly developed processing line ensures the production of high‐quality safflower oil and has great potential for small enterprises in the cereal‐processing industry. The article highlights the importance of primary purification of plant oils and its impact on the quality of the final product.Practical applicationsThe following conclusions emerged from the research. The relevance of fat oil growing, including signs of increased popularity of safflower oil in Kazakhstan and in the world has been studied. Various types (husking, compressing, sedimentation, centrifuging and filtering) of primary purification of safflower and purification of oil from mechanical impurities have been investigated. The dependence of extraction of pressed safflower oil on the speed of rotation of the filter and settling rotor and the equipment structure itself has been studied. The sheller‐compress for purification of safflower has been developed to combine husking and compressing processes to increase the oil content of the processed oil raw material and the productivity of the processing equipment. The centrifuge is designed for primary purification of safflower oil from mechanical impurities, allowing to combine the sedimentation and filtering processes due to rotors and to obtain purified safflower oil. The problem of intensification of the purification process is characterized by the ratio of different defined parameters. As a result, optimum parameters were determined and a processing line was developed with the use of a sheller‐compress and a centrifuge with a filtering and pre.
Diabetes treatment deintensification in Australians with dementia compared to the general population: A national cohort study
Authors: Picton Leonie J. , George Johnson , Bell J. Simon , Ilomaki Jenni S. 
Published: June 2023

AbstractBackgroundDiagnosis of dementia may change peoples' goals of care. In people with diabetes, this may lead to relaxing treatment targets and reducing the use of diabetes medications. The aim of this study was to examine changes in diabetes medication use before and after initiating medication for dementia.MethodsA national cohort of people aged 65–97 years, living with dementia and diabetes, and a general population cohort with diabetes matched for age, sex, and index date were extracted from the Australian national medication claims database. Trajectories of diabetes medication use, expressed as mean defined daily dose (DDD) each month for each individual from 24 months before to 24 months after the index date, were estimated using group‐based trajectory modeling (GBTM). Cohorts were analyzed separately.ResultsPeople with dementia (N = 1884) and the matched general population (N = 7067) had a median age of 80 years (interquartile range 76–84) and 55% were female. In both models, people exhibited one of five diabetes medication trajectories, with 16.5% of people with dementia and 24.0% of the general population assigned to trajectories that represented deintensification. In the general population model, those on deintensifying trajectories were older than those on stable trajectories (median 83 vs. 79 years). In the dementia cohort model, those on high or low deintensifying trajectories were slightly older (median age 81 or 82, respectively, vs. 80 years) and had at least 1 more comorbidity (median 8 or 7, respectively, vs. 6) than those on stable trajectories.ConclusionsInitiating medication for dementia does not appear to be a trigger for deintensification of diabetes treatment regimens. Deintensification was more common in the general population; people living with dementia are potentially overtreated for diabetes.
Brain FDG‐PET findings in chimeric antigen receptor T‐cell therapy neurotoxicity for diffuse large B‐cell lymphoma
Authors: Morbelli Silvia , Gambella Massimiliano , Raiola Anna Maria , Ghiggi Chiara , Bauckneht Matteo , Raimondo Tania Di , Lapucci Caterina , Sambuceti Gianmario , Inglese Matilde , Angelucci Emanuele 
Published: June 2023

AbstractBackground and PurposeChimeric antigen receptor (CAR) T‐cell therapy is potentially associated with treatment‐related toxicities mainly consisting of cytokine release syndrome (CRS) and immune‐effector cell‐associated neurotoxicity syndrome (ICANS). We evaluated brain metabolic correlates of CRS with and without ICANS in diffuse large B‐cell lymphoma patients treated with CAR‐T.MethodsTwenty‐one refractory DLCBLs underwent whole‐body and brain [18F]‐fluorodeoxyglucose (FDG) PET before and 30 days after treatment with CAR‐T. Five patients did not develop inflammatory‐related side effects, 11 patients developed CRS, while in 5 patients CRS evolved in ICANS. Baseline and post‐CAR‐T brain FDG‐PET were compared with a local controls dataset to identify hypometabolic patterns both at single‐patient and group levels (p < .05 after correction for family‐wise error [FWE). Metabolic tumor volume (MTV) and total lesion glycolysis (TLG) were computed on baseline FDG‐PET and compared between patients’ subgroups (t‐test).ResultsICANS showed an extended and bilateral hypometabolic pattern mainly involving the orbitofrontal cortex, frontal dorsolateral cortex, and anterior cingulate (p < .003 FWE‐corrected). CRS without ICANS showed significant hypometabolism in less extended clusters mainly involving bilateral medial and lateral temporal lobes, posterior parietal lobes, anterior cingulate, and cerebellum (p < .002 FWE‐corrected). When compared, ICANS showed a more prominent hypometabolism in the orbitofrontal and frontal dorsolateral cortex in both hemispheres than CRS (p < .002 FWE‐corrected). Mean baseline MTV and TLG were significantly higher in ICANS than CRS (p < .02).ConclusionsPatients with ICANS are characterized by a frontolateral hypometabolic signature coherently with the hypothesis of ICANS as a predominant frontal syndrome and with the more prominent susceptibility of frontal lobes to cytokine‐induced inflammation.
USDA Summer Meals Program: Lack of Program Awareness Contributes to Unmet Need Among Nonparticipants
Authors: Vericker Tracy , Rothstein Melissa , Gabay Mary , Gola Alice Ann H. , Lovellette Grant 
Published: June 2023

ABSTRACTBACKGROUNDParticipation in the US Department of Agriculture's summer meals program is consistently lower compared to National School Lunch Program (NSLP) participation, even though the programs target the same population of children. The purpose of this study was to elucidate reasons for participation and nonparticipation in the summer meals program.METHODSA nationally representative sample of 4688 households with children ages 5 through 18 years living near a summer meals site in 2018 completed a survey about their reasons for participation or nonparticipation in the summer meals program, features that would help nonparticipants to attend, and household food security status.RESULTSAlmost half of all households living near a summer meal site were food insecure (45%) and most (77%) had incomes at or below 130% of the federal poverty level. Most participant caregivers (74%) sent their children to summer meal sites for the free meals, while 46% of nonparticipant caregivers said they did not attend because they were unaware of the program.CONCLUSIONSDespite a high level of food insecurity among all households, the most reported reason for not attending the summer meals program was unawareness of the program. These findings highlight a need for better program visibility and outreach.
Elective induction of labour at full‐term gestations and childhood school outcomes
Authors: Selvaratnam Roshan J , Wallace Euan M , Rolnik Daniel L , Mol Ben W , Butler Sarah E , Bisits Andrew , Lawson Janna , Davey Mary‐Ann 
Published: June 2023

AimTo explore the association between induction of labour at full‐term gestations in low‐risk nulliparous women and childhood school outcomes.MethodsA retrospective whole‐of‐population cohort study linking perinatal data to educational test scores at grades 3, 5 and 7 in Victoria, Australia. Low‐risk nulliparous women with singleton pregnancies induced at 39 and 40 weeks without a medical indication were compared to those expectantly managed from that week of gestation. Multivariable logistic regressions were used as well as generalised estimating equations on longitudinal data.ResultsAt 39 weeks, there were 3687 and 103 164 infants in the induction and expectant arms, respectively. At 40 weeks' gestation, there were 7914 and 70 280 infants, respectively. Infants born to nulliparous women induced at 39 weeks' gestation had significantly poorer educational outcomes at grade 3 (adjusted odds ratio (aOR) = 1.39, 95% confidence interval (CI): 1.13–1.70) but not grades 5 (aOR = 1.05, 95% CI: 0.84–1.33) and 7 (aOR = 1.07, 95% CI: 0.81–1.40) compared to those expectantly managed. Infants born to nulliparous women induced at 40 weeks had comparable educational outcomes at grade 3 (aOR = 1.06, 95% CI: 0.90–1.25) but poorer educational outcomes at grades 5 (aOR = 1.23, 95% CI: 1.05–1.43) and 7 (aOR = 1.23, 95% CI: 1.03–1.47) compared to those expectantly managed.ConclusionsThere were inconsistent associations between elective induction of labour at full‐term gestations in low‐risk nulliparous women and impaired childhood school outcomes.
From chaos to creation: The mutual causality between supply chain disruption and innovation in low‐income markets
Authors: Oke Adegoke , Nair Anand 
Published: June 2023

AbstractLow‐income markets have unique constraints that trigger the co‐evolution of innovation and disruption in such markets. When disruptions occur in global supply chains, and in particular, in low‐income markets, they spur innovations that may be necessary to address both existing and potential future disruptions. However, such innovations in turn create disruptions to existing supply chains, and they may also create new supply chains. Therefore, this study theorizes in support of the mutual causality between innovation and disruption in low‐income markets. The focus is on low‐income market contexts because of the unique opportunities and constraints that exist in these contexts, resulting in interesting and unique dynamics between innovation and disruption. Further, the mechanisms through which innovation‐disruption mutual causality occurs—as well as the boundary conditions for these mechanisms—are identified. This culminates in a theoretical framework surrounding the interrelationship between disruption and innovation in low‐income markets. Theoretical and practical implications are explored, and potential areas for future research are delineated.
Classifying Muslims: Contextualizing Religion and Race in the United Kingdom and Germany
Authors: Becker Elisabeth , Rinado Rachel , Guhin Jeffrey 
Published: June 2023

AbstractSince the late 20th century, public discourse in Muslim‐minority countries has centered around the question of how to classify Muslims. In this paper, we compare the state, academic, and self‐classification of Muslims in two countries: the United Kingdom and Germany. We propose that the historical experience of anti‐Semitism makes religion a more salient master category to understand Muslims in Germany, while the history of both anti‐Semitism and anti‐Black racism largely resulting from colonial domination means that religion together with race are master categories used to understand Muslims in the United Kingdom. Through this multilayered ethnographic and historical analysis, we challenge taken‐for‐granted assumptions in both the political and academic milieu about what it means to be Muslim, emphasizing the importance of the interplay between sociopolitical categories and self‐identifications.
Practitioners' perspectives on preparing for and delivering remote psychological support in Nepal, Perú and the United States during COVID‐19
Authors: Pedersen Gloria A. , Elnasseh Abdelrhman , Bhattacharya Bani , Moran Leydi , Neupane Vibha , Galea Jerome T. , Contreras Carmen , Pfeffer Kendall A. , Brown Adam D. , Sangraula Manaswi , Luitel Nagendra P. , Kohrt Brandon A. 
Published: June 2023

AbstractIntroductionThe COVID‐19 pandemic has propelled a global paradigm shift in how psychological support is delivered. Remote delivery, through phone and video calls, is now commonplace around the world. However, most adoption of remote delivery methods is occurring without any formal training to ensure safe and effective care.ObjectiveThe purpose of this applied qualitative study was to determine practitioners' experiences of rapidly adapting to deliver psychological support remotely during COVID‐19.DesignWe used a pragmatic paradigm and applied approach to gain perspectives related to the feasibility and perceived usefulness of synchronous remote psychological support, including views on how practitioners can be prepared.MethodsKey informant interviews were conducted remotely with 27 specialist and non‐specialist practitioners in Nepal, Perú and the USA. Interviewees were identified through purposeful sampling. Data were analysed using framework analysis.ResultsRespondents revealed three key themes: (i) Remote delivery of psychological support raises unique safety concerns and interference with care, (ii) Remote delivery enhances skills and expands opportunities for delivery of psychological support to new populations, and (iii) New training approaches are needed to prepare specialist and non‐specialist practitioners to deliver psychological support remotely.ConclusionsRemote psychological support is feasible and useful for practitioners, including non‐specialists, in diverse global settings. Simulated remote role plays may be a scalable method for ensuring competency in safe and effective remotely‐delivered care.