bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mild Cognitive Impairment in African Americans Is Associated with Differences in EEG Theta/Beta Ratio
Authors: Martin Tim , Kero Katherine , Požar Rok , Giordani Bruno , Kavcic Voyko 
Published: May 2023

Background: Identification of older individuals with increased risk for cognitive decline can contribute not only to personal benefits (e.g., early treatment, evaluation of treatment), but could also benefit clinical trials (e.g., patient selection). We propose that baseline resting-state electroencephalography (rsEEG) could provide markers for early identification of cognitive decline. Objective: To determine whether rsEEG theta/beta ratio (TBR) differed between mild cognitively impaired (MCI) and healthy older adults. Methods: We analyzed rsEEG from a sample of 99 (ages 60–90) consensus-diagnosed, community-dwelling older African Americans (58 cognitively typical and 41 MCI). Eyes closed rsEEGs were acquired before and after participants engaged in a visual motion direction discrimination task. rsEEG TBR was calculated for four midline locations and assessed for differences as a function of MCI status. Hemispheric asymmetry of TBR was also analyzed at equidistant lateral electrode sites. Results: Results showed that MCI participants had a higher TBR than controls ( p = 0.04), and that TBR significantly differed across vertex location ( p < 0.001) with the highest TBR at parietal site. MCI and cognitively normal controls also differed in hemispheric asymmetries, such that MCI show higher TBR at frontal sites, with TBR greater over right frontal electrodes in the MCI group ( p = 0.003) and no asymmetries found in the cognitively normal group. Lastly, we found a significant task aftereffect (post-task compared to pre-task measures) with higher TBR at posterior locations (Oz p = 0.002, Pz p = 0.057). Conclusion: TBR and TBR asymmetries differ between MCI and cognitively normal older adults and may reflect neurodegenerative processes underlying MCI symptoms.
MENINGKATKAN HASIL BELAJAR SISWA PADA PELAJARAN BAHASA INGGRIS MELALUI STRATEGI PEMBELAJARAN COOPERATIVE TIPE STUDENT TEAM ACHIEVEMENT DIVISION (STAD)
Authors: Yenni Nuraeni Manalu  
Published: May 2023

Tujuan penelitian ini adalah untuk: Meningkatkan hasil belajar siswa Kelas IX-7 melalui strategi pembelajaran Cooperative Tipe Student Team Achievement Divison (STAD) di SMP Negeri 1 Labuhan Deli pada tahun pelajaran 2018/2019. Metode yang digunakan dalam penelitian adalah Metode Penelitian Tindakan Kelas dengan menggunakan 2 siklus. Subjek penelitian ini adalah siswa Kelas IX-7 SMP Negeri 1 Labuhan Deli sebanyak 29 orang. Instrumen yang digunakan untuk memperoleh data adalah menggunakan test, angket dan observasi. Rentang nilai untuk tes adalah 1-100. Teknik analisa data yang digunakan adalah dengan perhitungan nilai rata-rata siswa, persentase nilai ketuntasan siswa dan persentase nilai siswa yang belum tuntas. Hasil Penelitian ini menunjukkan terdapat peningkatan hasil belajar dengan menerapkan strategi pembelajaran Cooperative Tipe Student Team Achievement Divison (STAD) dengan hasil sebagai berikut: (1) Terdapat peningkatan rata-rata hasil belajar siswa, dimana pada tes awal rata-rata hasil belajar siswa adalah 40,0 pada siklus I meningkatkan menjadi 66,21 kemudian pada siklus II meningkat lagi menjadi 76,55. (2).Terdapat peningkatan jumlah siswa yang tuntas, dimana pada tes awal jumlah siswa yang tuntas hanya 0%, meningkat menjadi 65,52% pada siklus I kemudian meningkat lagi menjadi 86,21% pada siklus II,(3).Terdapat penurunan jumlah siswa yang tidak tuntas, dimana pada tes awal jumlah siswa yang tidak tuntas mencapai 100%, pada siklus I menurun menjadi 34,48% kemudian pada siklus II menurun lagi menjadi 13,79% dengan kata lain hanya 4 siswa saja yang memperoleh nilai dibawah 60 dan selebihnya (25) siswa memperoleh nilai 70 dan di atas 70.
Pengaruh Lingkungan Kerja Fisik terhadap Kinerj Karyawan pada Kantor Badan Penanggulangan Bencana Daerah Kabupaten Batanghari
Authors: Sary Mella 
Published: May 2023

The purpose of this study is as follows: 1.) To find out and describe the work environment and employee performance at the office of the Regional Disaster Management Agency of Batanghari Regency. 2.) To analyze the influence of the physical work environment on employee performance in the office of the regional disaster management agency of Batanghari regency. The type of data required and collected in this study is quantitative data. The object of this research is Office of the Regional Disaster Management Agency Of Batanghari Regency. Sources of data in this study are Office of the Regional Disaster Management Agency Of Batanghari Regency., and Questionnaires and respondents to the office of the Batanghari district disaster management agency. Based on the resuts of the study obtained linear regression value that is Y = 1.518 + 0.511 X, with a value of R and a R2 value of 0.238 in the test t work environment affects employee performance in the office of the regional disaster management agency with a value of 3.447 and a significant value of 0.001.The conclusion in this study is that the physical work environment significantly affects employee performance in the office of the Regional Disaster Management Agency of Batanghari district this is evidenced by a significant value of 0.001<0.05 results coefficient of determination of 23.8% show the value of employee performance is influenced by the remaining physical work environment of 76.2% the value of employee performance is influenced or explained by other factors that are not studied. By this researcher.
Pengaruh Profitabilitas terhadap Return Saham pada Sub Sektor Konstruksi Bangunan yang Terdaftar Di Bursa Efek Indonesia Periode 2015-2020
Authors: Putri April Nadia 
Published: May 2023

This study aims to determine the effect of simultan and partial variable Return On Asset, Return On Equity, Net Profit Margin, and Gross Profit Margin.This research uses descriptive quantitative method and the source of the data in thid study was obtained through several literatures related to research, the website of the company concerned, financial statements and the Indonesia Stock Exchange (IDX).The object of this research is a Building Construction Company which is one of the Sub-Sector categories on the Indonesian stock exchange with a research population of 18 companies, only 6 companies are the research samples according to the sampling criteria.The examiner shows that simultaneously Return On asset,Return On Equity,Net Profit Margin and Gross Profit Margin have a significant effect on stock Return.With a significant value of 0,026, the Return On Asset test partially has a positive effect with a significant value of 0,022 on stock Return. Return On Equity has no positive effect with a significant value of 0,086 on stock Return. Net Profit Margin has a positive effect with a significant value of 0,031 on stock Return. Gross Profit Margin has no positive effect with a significant value of 0,512 0n stock return. The results of this study indicate that simultaneously the Return On Asset, Return On Equity, Net Profit Margin and Gross Profit Margin variables have a significant effect on stock Returns. Partially, return on Asset and Net Profit Margin have a significant effeck, while Return On Equity and Gross Profit Margin have no significant effect. For further writers, it is better to use more variables to see effect of variables on stock Returns, so that investors can be taken into consideration in making decisions.
Pengaruh Pengembangan Sumber Daya Manusia terhadap Kinerja Pegawai Pada BPJS Ketenagakerjaan Kota Jambi
Authors: Fitrhiyah Khalilah 
Published: May 2023

Work supervision plays a very important role in employee performance. Therefore, the purpose of this research is to describe the work supervision and performance of employees at work, and to find out and analyze the effect of work supervision employee performance at work in SDN 179 Tanjung Jabung Timur Kecamatan Nipah Panjang. Research methods in this study is descriptive and quantitative method. Data analyze use SPSS Ver 22 and using models simple linier regression with result of count Y = 1,116+0,527X+e. The test of determination with R2 of 37,6%. T test by comparison tcount 3,547 > ttable 0,3338 then Ho accepted Hi be. Rejected. To analyze the effect of work supervision on performance of employees on SDN 179 Tanjung Jabung Timur Kecamatan Nipah Panjang. The distribution of questionnaires with a population of 35 people in 2021 , then the formula used to find samples according to Istijanto (2009 :114)so that the sample in this study amounted to 35 people respondent.Work supervision regression coefficient (X) is 0,525, meaning that work supervision (X) has increased by 1%, so performance of employees at work (Y) SDN 179 Tanjung Jabung Timur Kecamatan Nipah Panjang. The coefficient of determination is known from the value of R2=0,376 (37,6%) which means that work supervision(X) is able to explain performance of employees at work (Y) at the SDN 179 Tanjung Jabung Timur Kecamatan Nipah Panjang that is equal to 37,6% and the remaining 62,4% is influenced by other variables. Not investigated in this study. Based on t-test, t-count value is 3,547 and the t-table is 0,3338. From the comparison results, it can be seen that the test by comparison tcount 3,547 > ttable 0,3338 then Ho accepted Hi be. Rejected. Meaning that Work supervision affect c performance of employees at work at SDN 179 Tanjung Jabung Timur Kecamatan Nipah Panjang.
Başörtüsü Tartışmalarına Dair Bir Araştırma
Authors: YILDIZ Recep 
Published: May 2023

Giriş
2022 yılının son aylarında başörtüsü bir kez daha sıcak siyasi gündemi belirledi. Hükümet, Kılıçdaroğlu'nun kalıcı çözüm önerisine anayasa değişikliği veya referandumla yanıt verdi. 14 yıl önce, Şubat 2008'de, başörtüsü serbestiyeti getiren 5735 sayılı kanun Cumhurbaşkanlığı'nın onayından sonra Resmi Gazete'de yayımlanmıştı. Ancak birkaç ay içinde Anayasa Mahkemesi kararıyla kanun iptal edilmişti. Bu bir aylık süre başörtüsü tartışmalarının en yoğun olduğu dönemlerden biri olmuştu. O nedenle araştırma, 2008 yılının Ocak ve Şubat aylarında ortaya atılan tezleri, başörtüsü yasağını destekleyen ve karşı çıkanların gerekçeleriyle birlikte ele almaktadır. Amacı da günümüzde yaşanan süreci tematik olarak tasnif edilmiş gerekçeler ışığında değerlendirmektir.
Gereç ve Yöntemler
Araştırma literatür taramasının yanında, konuya ilişkin gazete yazılarını ve söylemleri etkileşimsiz analitik bir yaklaşımla, zamana özgü tarihsel bir analiz deseni ve içerik analizi tekniği ile değerlendirmektedir. Sonuç
Toplanan verilerin analizi sonrasında başörtüsü yasağı savunuculuğunun ve yasağa itirazların şu temalar etrafında yoğunlaştığı görülmüştür. Siyasi sembol, laiklik ve cumhuriyetin kazanımları, özgürlük, kamusal alan, dini gereklilik. Varılan sonuç ve değerlendirme ise yıllardır çözülemeyen başörtüsü sorununa kalıcı bir çözüm getirilmesinin toplumsal barış ve refaha katkı sağlayacağıdır.
A description of the elevation of pericardial cortisol: cortisone ratio in patients with tuberculous pericarditis
Authors: Shenje Justin Tapiwa , Raubenheimer Peter , Wiesner Lubbe , Ross Ian 
Published: May 2023

Pulmonary tuberculosis is an inflammatory disease associated with an elevated cortisol/cortisone ratio at the site of infection and an array of cytokine changes. Tuberculous pericarditis is a less common but more lethal form of tuberculosis and has a similar inflammatory process in the pericardium. As the pericardium is largely inaccessible, the effect of tuberculous pericarditis on pericardial glucocorticoids is largely unknown. We wished to describe pericardial cortisolcortisone ratio in relation to plasma and saliva cortisol/cortisone ratios and the associated changes in cytokine concentrations. The median (interquartile range) of plasma, pericardial, and saliva cortisol concentration was 443 (379–532), 303 (257–384), and 20 (10–32) nmol/L, respectively, whereas the median (interquartile range) of plasma, pericardial, and saliva cortisone concentrations was 49 (35–57), 15.0 (0.0–21.7), and 37 (25–55) nmol/L, respectively. The cortisol/cortisone ratio was highest in pericardium with median (interquartile range) of 20 (13–445), followed by plasma of 9.1 (7.4–12.1) and saliva of 0.4 (0.3–0.8). The elevated cortisol/cortisone ratio was associated with elevated pericardial, interferon gamma, tumor necrosis factor–alpha, interleukin-6, interleukin-8, and induced protein 10. Administration of a single dose of 120 mg of prednisolone was associated with the suppression of pericardial cortisol and cortisone within 24 h of administration. The cortisol/cortisone ratio was highest at the site of infection, in this case, the pericardium. The elevated ratio was associated with a differential cytokine response. The observed pericardial cortisol suppression suggests that 120 mg of prednisolone was sufficient to evoke an immunomodulatory effect in the pericardium.
Rapid response of vascular plants and insects to restoration of montane grasslands
Authors: Helbing Felix , Fartmann Thomas , Morkel Carsten , Poniatowski Dominik 
Published: May 2023

IntroductionIndustrialization has ushered in massive changes in agriculture. Particularly in low mountain ranges, large-scale afforestation with Norway spruce on traditionally managed, semi-natural grasslands has caused a severe decline in biodiversity. Tree removal, hay transfer and resumption of grazing or mowing are typical measures to re-create species-rich grasslands. The aim of this study was to use vascular plants and three insect taxa (leafhoppers, true bugs, and grasshoppers) as bioindicators to evaluate the success of montane grassland restoration on former spruce forests in Central Europe. In addition, we intended to identify the drivers of species richness within the studied grasslands in order to derive suitable recommendations for habitat management.MethodsWe analyzed two different treatments: (i) grazed restoration sites where trees had been cut and species-rich green hay had been applied (N = 9) and (ii) target sites with a long continuity of low-intensity grazing (N = 9).Results and DiscussionOur study revealed that all studied taxa responded rapidly to the restoration measures. After a development period of 3 to 5 years, we found no differences in species richness and diversity of leafhoppers, true bugs and grasshoppers (all, target and threatened species). In addition, non-metric multidimensional scaling showed a large overlap in species composition between restoration and target grasslands. Among target and threatened species, vascular plants displayed the same pattern as insects and reached similar values when comparing the two treatments. However, total species richness and diversity of vascular plants were still higher on the target sites and species composition overlapped only partially. Grazing intensity was the predictor with the highest explanatory power in multivariable (Generalized) Linear Mixed-effects Models, being negatively related to species richness of leafhoppers and true bugs. We conclude that the measures implemented were effective in re-establishing target communities of different taxa. The transfer of seed-containing hay enabled or accelerated the development of the vegetation. Insects, on the other hand, were able to recolonize the restored grasslands on their own, given that these sites were embedded in a network of species-rich grasslands. With regard to insects (e.g., leafhoppers and true bugs), it should be ensured that grazing is applied at low intensity.
Association between TRP channels and glutamatergic synapse gene polymorphisms and migraine and the comorbidities anxiety and depression in a Chinese population
Authors: Wang Mingxue , Gu Yujia , Meng Shuhan , Kang Lixin , Yang Jing , Sun Degang , Liu Yuxing , Wan Ze , Shan Yi , Xue Dongjie , Su Chang , Li Shufen , Yan Ran , Liu Yu , Zhao Yashuang , Pan Yonghui 
Published: May 2023

Background: Genetic and environmental factors contribute to migraine and the comorbidities of anxiety and depression. However, the association between genetic polymorphisms in the transient receptor potential (TRP) channels and glutamatergic synapse genes with the risk of migraine and the comorbidities of anxiety and depression remain unclear.Methods: 251 migraine patients containing 49 comorbidities with anxiety and 112 with depression and 600 controls were recruited. A customized 48-plex SNPscan kit was used for genotyping 13 SNPs of nine target genes. Logistic regression was conducted to analyze these SNPs’ association with the susceptibility of migraine and comorbidities. The generalized multifactor dimension reduction (GMDR) was applied to analyze the SNP-SNP and gene-environment interactions. The GTEx database was used to examine the effects of the significant SNPs on gene expressions.Results: The TRPV1 rs8065080 and TRPV3 rs7217270 were associated with an increased risk of migraine in the dominant model [ORadj (95% CI): 1.75 (1.09–2.90), p = 0.025; 1.63 (1.02–2.58), p = 0.039, respectively]. GRIK2 rs2227283 was associated with migraine in the edge of significance [ORadj (95% CI) = 1.36 (0.99–1.89), p = 0.062]. In migraine patients, TRPV1 rs222741 was associated with both anxiety risk and depression risk in the recessive model [ORadj (95% CI): 2.64 (1.24–5.73), p = 0.012; 1.97 (1.02–3.85), p = 0.046, respectively]. TRPM8 rs7577262 was associated with anxiety (ORadj = 0.27, 95% CI = 0.10–0.76, p = 0.011). TRPV4 rs3742037, TRPM8 rs17862920 and SLC17A8 rs11110359 were associated with depression in dominant model [ORadj (95% CI): 2.03 (1.06–3.96), p = 0.035; 0.48 (0.23–0.96), p = 0.042; 0.42 (0.20–0.84), p = 0.016, respectively]. Significant eQTL and sQTL signals were observed for SNP rs8065080. Individuals with GRS (Genetic risk scores) of Q4 (14–17) had a higher risk of migraine and a lower risk of comorbidity anxiety than those with Genetic risk scores scores of Q1 (0–9) groups [ORadj (95% CI): 2.31 (1.39–3.86), p = 0.001; 0.28 (0.08–0.88), p = 0.034, respectively].Conclusion: This study suggests that TRPV1 rs8065080, TRPV3 rs7217270, and GRIK2 rs2227283 polymorphism may associate with migraine risk. TRPV1 rs222741 and TRPM8 rs7577262 may associate with migraine comorbidity anxiety risk. rs222741, rs3742037, rs17862920, and rs11110359 may associate with migraine comorbidity depression risk. Higher GRS scores may increase migraine risk and decrease comorbidity anxiety risk.
A syndrome featuring developmental disorder of the nervous system induced by a novel mutation in the TCF20 gene, rarely concurrent immune disorders: a case report
Authors: Huang Si , Xu Jiaxin , Li Yiyang , Mo Wenhui , Lin Xiuwen , Wang Yajun , Liang Fujian , Bai Yan , Huang Guochun , Chen Jing , Xin Jing , Ma Guoda 
Published: May 2023

Background: The expression of TCF20 is the most widespread in brain tissue. TCF20 depletion or mutation can affect the proliferation and differentiation of embryonic neurons, leading to developmental disorder of the central nervous system and subsequent rare syndrome featuring.Case presentation: Here, we report a 3-year-old boy carrying a novel frameshift mutation in TCF20, c.1839_1872del (p.Met613IlefsTer159), resulting in multisystem disease. In addition to symptoms of neurodevelopmental disorder, a large head circumference, special appearance, overgrowth, abnormal testicular descent. Remarkably, previously infrequently reported symptoms of the immune system such as hyperimmunoglobulinemia E (hyper-IgE), immune thrombocytopenic purpura, cows milk protein allergy, and wheezy bronchitis, were observed.Conclusion: This study broadens the mutation spectrum of the TCF20 and the phenotypic spectrum of TCF20-associated disease.
Bulk and single-cell RNA-sequencing analyses along with abundant machine learning methods identify a novel monocyte signature in SKCM
Authors: Liu Yuyao , Zhang Haoxue , Mao Yan , Shi Yangyang , Wang Xu , Shi Shaomin , Hu Delin , Liu Shengxiu 
Published: May 2023

BackgroundGlobal patterns of immune cell communications in the immune microenvironment of skin cutaneous melanoma (SKCM) haven’t been well understood. Here we recognized signaling roles of immune cell populations and main contributive signals. We explored how multiple immune cells and signal paths coordinate with each other and established a prognosis signature based on the key specific biomarkers with cellular communication.MethodsThe single-cell RNA sequencing (scRNA-seq) dataset was downloaded from the Gene Expression Omnibus (GEO) database, in which various immune cells were extracted and re-annotated according to cell markers defined in the original study to identify their specific signs. We computed immune-cell communication networks by calculating the linking number or summarizing the communication probability to visualize the cross-talk tendency in different immune cells. Combining abundant analyses of communication networks and identifications of communication modes, all networks were quantitatively characterized and compared. Based on the bulk RNA sequencing data, we trained specific markers of hub communication cells through integration programs of machine learning to develop new immune-related prognostic combinations.ResultsAn eight-gene monocyte-related signature (MRS) has been built, confirmed as an independent risk factor for disease-specific survival (DSS). MRS has great predictive values in progression free survival (PFS) and possesses better accuracy than traditional clinical variables and molecular features. The low-risk group has better immune functions, infiltrated with more lymphocytes and M1 macrophages, with higher expressions of HLA, immune checkpoints, chemokines and costimulatory molecules. The pathway analysis based on seven databases confirms the biological uniqueness of the two risk groups. Additionally, the regulon activity profiles of 18 transcription factors highlight possible differential regulatory patterns between the two risk groups, suggesting epigenetic event-driven transcriptional networks may be an important distinction. MRS has been identified as a powerful tool to benefit SKCM patients. Moreover, the IFITM3 gene has been identified as the key gene, validated to express highly at the protein level via the immunohistochemical assay in SKCM.ConclusionMRS is accurate and specific in evaluating SKCM patients’ clinical outcomes. IFITM3 is a potential biomarker. Moreover, they are promising to improve the prognosis of SKCM patients.