bluuebunny/crossref_metadata_2025_split huggingface dataset:
V-052 Laparoscopic Treatmenf of Spiegel Strangulated Hernia by TAPP Approach
Authors: De Armas Conde M , Gianchandani Moorjani R , Reyes Correa B , Orti Rodríguez R , Díaz López C , Sánchez González J M , Moneva Arce E , Barrera Gómez M Á 
Published: May 2023

Abstract
Repair of hernia is a very common procedure performed by a general surgeon. Laparoscopic approach has demonstrated advantages over direct approach: less complications, faster recovery and less postoperative pain. In Spiegel hernias, if the ring is less than 2 cm, a simple laparoscopic suture can be performed; however, laparoscopic transabdominal preperitoneal (TAPP) hernioplasty has lower risk of recurrence.
We report the case of a woman with and strangulated Spiegel hernia which was attempted by TAPP hernioplastly.
63 year old woman consulted in emergency for a swelling of the left flank an occlusive syndrome. Physical examination found a distended abdomen with presence of a painful mass in the left flank, irreducible.
Radiological findings were inconclusive, so an ultrasound was performed which showed an abdominal wall defect of 15×15 mm with an ischemic small bowel loop herniation: strangulated Spiegel hernia.
A exploratory laparoscopy was attempted emergently. It found a 2 cm hole at the abdominal wall with 15 cm of ischemic small bowel. Ischemia was confirmed with indocyanine green (ICG).
Afterwards, TAPP herniopplasty was performed: peritoneal incision to create a peritoneal flap. The peritoneal sac was reduced and then, we closed the defect. After this, we placed a prosthesis covering the area of weakness in the pre-peritoneal space
and fixed with biological glue. At least, we covered the mesh with the peritoneal closure.
Finally, we performed a resection of ischemic bowel and isoperistaltic mechanical laterolateral extracorporeally anastomosis.
She had an unremarkable post-operative course, and she was discharge on the 4th postoperative day.
Impact of network treatment in patients with resected pancreatic cancer on use and timing of chemotherapy and survival
Authors: Hopstaken Jana S , Vissers Pauline A J , Quispel Rutger , de Vos-Geelen Judith , Brosens Lodewijk A A , de Hingh Ignace H J T , van der Geest Lydia G , Besselink Marc G , van Laarhoven Kees J H M , Stommel Martijn W J 
Published: May 2023

Abstract

Background
Centralization of pancreatic cancer surgery aims to improve postoperative outcomes. Consequently, patients with pancreatic cancer may undergo pancreatic surgery in an expert centre and adjuvant chemotherapy in a local hospital (network treatment). The aim of this study was to assess whether network treatment has an impact on time to chemotherapy, failure to complete adjuvant chemotherapy, and survival. Second, whether these parameters varied between pancreatic networks was studied.

Methods
This retrospective study included all patients diagnosed with non-metastatic pancreatic ductal adenocarcinoma who underwent pancreatic surgery and adjuvant chemotherapy, registered in the Netherlands Cancer Registry (2015–2020). Time to chemotherapy was defined as the time between surgery and the start of adjuvant chemotherapy. Completion of adjuvant chemotherapy was defined as the receipt of 12 cycles of FOLFIRINOX or six cycles of gemcitabine. Analysis was performed with linear mixed models and multilevel logistic regression models. Cox regression analyses were performed for survival.

Results
In total, 1074 patients were included. Network treatment was observed in 468 patients (43.6 per cent) and was not associated with longer time to chemotherapy (0.77 days, standard error (s.e.) 1.14, P = 0.501), failure to complete adjuvant chemotherapy (odds ratio (OR) = 1.140, 95 per cent c.i. 0.86 to 1.52, P = 0.349), and overall survival (hazards ratio (HR) = 1.04, 95 per cent c.i. 0.88 to 1.22, P = 0.640). Significant variation between the networks was observed for time to chemotherapy (range 40.5–63 days, P &lt; 0.0001) and completion of adjuvant chemotherapy (range 19–52 per cent, P = 0.030). Adjusted for case mix, time to chemotherapy significantly differed between networks.

Conclusion
In this nationwide analysis, network treatment in patients with resected pancreatic cancer was not associated with longer time to chemotherapy, failure to complete adjuvant chemotherapy, and worse survival. Significant variation between pancreatic cancer networks was found for time to chemotherapy.
Study on carnauba wax as phase-change material integrated in evacuated-tube collector for solar-thermal heat production
Authors: Bartali Ruben , Bolognese Michele , Fronza Nicola , Prattico Luca , Zanetti Alberto , Osorio Tiago , Crema Luigi 
Published: May 2023

Abstract
The evacuated-tube collector (ETC) for solar heat production is one of the most efficient systems to convert Sun energy into usable energy. Unfortunately, some technological barriers are still present in solar-thermal heat systems that limit the use of these technologies to decarbonize processes. An important obstacle is the requirement for heat at stable temperatures, which is not always achievable by solar fields, e.g. variable sky. For that reason, in this work, we studied the phase-change materials embedded in the ETC to keep stable the water temperature for a short period (minutes, hours). In this study, carnauba wax was used as a sustainable phase-change material (PCM), to avoid the use of PCM based on hydrocarbon waxes. The PCM has been packaged using a polyethylene bag inserted into an ETC with heat-pipe technologies and tested. The collector has been tested outdoors under solar irradiation and under shading conditions. The experimental results show that is possible to detect a sensible effect of the PCM on the temperature using 4 kg of carnauba wax while there is an important effect on the temperature stabilization using 9 kg of PCM. Using 9 kg of the PCM, we observed a stability of the outlet water temperature at 65°C for 30 minutes under shading conditions.
Gamified learning in dermatology and dermoscopy education: a paradigm shift
Authors: Donoso Francisca , Peirano Dominga , Longo Caterina , Apalla Zoe , Lallas Aimilios , Jaimes Natalia , Navarrete-Dechent Cristian 
Published: May 2023

AbstractTeaching methods in medical education have been changing. More recent teaching modalities have gone beyond the traditional delivery of knowledge, promoting learning motivation, and improving teaching and learning outcomes. ‘Gamification’ and ‘serious games’ are methodologies that use the principles of games to facilitate learning processes and the acquisition of skills and knowledge, thereby improving attitudes towards learning when compared with traditional teaching methods. As dermatology is a visual field, images are a key component of different teaching strategies. Likewise, dermoscopy, a noninvasive diagnostic technique that allows the visualization of structures within the epidermis and upper dermis, also uses images and pattern recognition strategies. A series of Apps using game-based strategy have been created to teach and facilitate dermoscopy learning; however, studies are required to demonstrate their effectiveness. This review summarizes the current evidence of game-based learning strategies in medical education, including dermatology and dermoscopy.
Noninvasive modulation of predictive coding in humans: causal evidence for frequency-specific temporal dynamics
Authors: Draganov Metodi , Galiano-Landeira Jordi , Doruk Camsari Deniz , Ramírez Jairo-Enrique , Robles Marta , Chanes Lorena 
Published: May 2023

Abstract
Increasing evidence indicates that the brain predicts sensory input based on past experiences, importantly constraining how we experience the world. Despite a growing interest on this framework, known as predictive coding, most of such approaches to multiple psychological domains continue to be theoretical or primarily provide correlational evidence. We here explored the neural basis of predictive processing using noninvasive brain stimulation and provide causal evidence of frequency-specific modulations in humans. Participants received 20 Hz (associated with top-down/predictions), 50 Hz (associated with bottom-up/prediction errors), or sham transcranial alternating current stimulation on the left dorsolateral prefrontal cortex while performing a social perception task in which facial expression predictions were induced and subsequently confirmed or violated. Left prefrontal 20 Hz stimulation reinforced stereotypical predictions. In contrast, 50 Hz and sham stimulation failed to yield any significant behavioral effects. Moreover, the frequency-specific effect observed was further supported by electroencephalography data, which showed a boost of brain activity at the stimulated frequency band. These observations provide causal evidence for how predictive processing may be enabled in the human brain, setting up a needed framework to understand how it may be disrupted across brain-related conditions and potentially restored through noninvasive methods.
Laparoscopic ischemic conditioning prior esophagectomy in selected patients: the ISCON trial
Authors: de Groot Eline , Schiffmann Lars M , van der Veen Arjen , Borggreve Alicia , de Jong Pim , Dos Santos Daniel Pinto , Babic Benjamin , Fuchs Hans , Ruurda Jelle , Bruns Christiane , van Hillegersberg Richard , Schröder Wolfgang 
Published: May 2023

Abstract
Anastomotic leakage (AL) after esophagectomy is the most impactful complication after esophagectomy. Ischemic conditioning (ISCON) of the stomach &gt;14 days prior to esophagectomy might reduce the incidence of AL. The current trial was conducted to prospectively investigate the safety and feasibility of laparoscopic ISCON in selected patients. This international multicenter feasibility trial included patients with esophageal cancer at high risk for AL with major calcifications of the thoracic aorta or a stenosis in the celiac trunk. Patients underwent laparoscopic ISCON by occlusion of the left gastric and the short gastric arteries followed by esophagectomy after an interval of 12–18 days. The primary endpoint was complications Clavien-Dindo ≥ grade 2 after ISCON and before esophagectomy. Between November 2019 and January 2022, 20 patients underwent laparoscopic ISCON followed by esophagectomy. Out of 20, 16 patients (80%) underwent neoadjuvant treatment. The median duration of the laparoscopic ISCON procedure was 45 minutes (range: 25–230). None of the patients developed intraoperative or postoperative complications after ISCON. Hospital stay after ISCON was median 2 days (range: 2–4 days). Esophagectomy was completed in all patients after a median of 14 days (range: 12–28). AL occurred in three patients (15%), and gastric tube necrosis occurred in one patient (5%). In hospital, the 30-day and 90-day mortalities were 0%. Laparoscopic ISCON of the gastric conduit is feasible and safe in selected esophageal cancer patients with an impaired vascular status. Further studies have to prove whether this innovative strategy aids to reduce the incidence of AL.
Artificial intelligence modelling to assess the risk of cardiovascular disease in oncology patients
Authors: Al-Droubi Samer S , Jahangir Eiman , Kochendorfer Karl M , Krive Marianna , Laufer-Perl Michal , Gilon Dan , Okwuosa Tochukwu M , Gans Christopher P , Arnold Joshua H , Bhaskar Shakthi T , Yasin Hesham A , Krive Jacob 
Published: May 2023

Abstract

Aims
There are no comprehensive machine learning (ML) tools used by oncologists to assist with risk identification and referrals to cardio-oncology. This study applies ML algorithms to identify oncology patients at risk for cardiovascular disease for referrals to cardio-oncology and to generate risk scores to support quality of care.

Methods and results
De-identified patient data were obtained from Vanderbilt University Medical Center. Patients with breast, kidney, and B-cell lymphoma cancers were targeted. Additionally, the study included patients who received immunotherapy drugs for treatment of melanoma, lung cancer, or kidney cancer. Random forest (RF) and artificial neural network (ANN) ML models were applied to analyse each cohort: A total of 20 023 records were analysed (breast cancer, 6299; B-cell lymphoma, 9227; kidney cancer, 2047; and immunotherapy for three covered cancers, 2450). Data were divided randomly into training (80%) and test (20%) data sets. Random forest and ANN performed over 90% for accuracy and area under the curve (AUC). All ANN models performed better than RF models and produced accurate referrals.

Conclusion
Predictive models are ready for translation into oncology practice to identify and care for patients who are at risk of cardiovascular disease. The models are being integrated with electronic health record application as a report of patients who should be referred to cardio-oncology for monitoring and/or tailored treatments. Models operationally support cardio-oncology practice. Limited validation identified 86% of the lymphoma and 58% of the kidney cancer patients with major risk for cardiotoxicity who were not referred to cardio-oncology.
Inverse association between apolipoprotein C-II and cardiovascular mortality: role of lipoprotein lipase activity modulation
Authors: Silbernagel Günther , Chen Yan Q , Rief Martin , Kleber Marcus E , Hoffmann Michael M , Stojakovic Tatjana , Stang Andreas , Sarzynski Mark A , Bouchard Claude , März Winfried , Qian Yue-Wei , Scharnagl Hubert , Konrad Robert J 
Published: May 2023

Abstract

Aims
Apolipoprotein C-II (ApoC-II) is thought to activate lipoprotein lipase (LPL) and is therefore a possible target for treating hypertriglyceridemia. Its relationship with cardiovascular risk has not been investigated in large-scale epidemiologic studies, particularly allowing for apolipoprotein C-III (ApoC-III), an LPL antagonist. Furthermore, the exact mechanism of ApoC-II–mediated LPL activation is unclear.

Methods and results
ApoC-II was measured in 3141 LURIC participants of which 590 died from cardiovascular diseases during a median (inter-quartile range) follow-up of 9.9 (8.7–10.7) years. Apolipoprotein C-II–mediated activation of the glycosylphosphatidylinositol high-density lipoprotein binding protein 1 (GPIHBP1)–LPL complex was studied using enzymatic activity assays with fluorometric lipase and very low-density lipoprotein (VLDL) substrates. The mean ApoC-II concentration was 4.5 (2.4) mg/dL. The relationship of ApoC-II quintiles with cardiovascular mortality exhibited a trend toward an inverse J-shape, with the highest risk in the first (lowest) quintile and lowest risk in the middle quintile. Compared with the first quintile, all other quintiles were associated with decreased cardiovascular mortality after multivariate adjustments including ApoC-III as a covariate (all P &lt; 0.05). In experiments using fluorometric substrate-based lipase assays, there was a bell-shaped relationship for the effect of ApoC-II on GPIHBP1–LPL activity when exogenous ApoC-II was added. In ApoC-II-containing VLDL substrate-based lipase assays, GPIHBP1–LPL enzymatic activity was almost completely blocked by a neutralizing anti-ApoC-II antibody.

Conclusion
The present epidemiologic data suggest that increasing low circulating ApoC-II levels may reduce cardiovascular risk. This conclusion is supported by the observation that optimal ApoC-II concentrations are required for maximal GPIHBP1–LPL enzymatic activity.
Diversity of culturable bacteria of freshwater environments from an altitudinal gradient in the eastern Cordillera of Colombia
Authors: Suescun-Sepulveda Jhon Alexander , Rondón González Fernando , Fuentes Lorenzo Jorge Luis 
Published: May 2023

AbstractBacteria are an essential biotic component in freshwater environments. A group of 262 bacterial strains of freshwater environments from an altitudinal gradient in the Eastern Cordillera of Colombia was identified using the 16S rRNA gene sequence analysis. Hill numbers and related diversity indices were calculated to know the bacteria diversity in this collection and environments. In addition, the Bray–Curtis index was also calculated to know the differences in genera composition between sampled localities and their relationship with altitudinal gradient. The identified bacterial strains were grouped into 7 major phylogenetic groups (Alphaproteobacteria, Betaproteobacteria, Gammaproteobacteria, Flavobacteriia, Actinomycetes, Clostridia, and Bacilli), 38 genera, and 84 distinctive species. Diversity analysis based on Hill numbers showed that the diversity concerning bacteria inhabiting freshwater environments was consistently high. Dominant genera were Klebsiella, Serratia, and Pseudomonas, although other genera such as Bacillus, Lelliottia, and Obesumbacterium were well represented per locality. The highest bacterial diversity came from localities Cimitarra and El Carmen del Chucurí, while those originating from Santa Bárbara and Páramo del Almorzadero were relatively lower diverse. Differences in diversity were found to be mainly due to the spatial replacement of one genus by another and, to a lesser extent, to the loss or gain of taxa.
Targeting the nucleotide metabolism of Trypanosoma brucei and other trypanosomatids
Authors: Hofer Anders 
Published: May 2023

Abstract
African sleeping sickness, Chagas disease, and leishmaniasis are life-threatening diseases that together affect millions of people around the world and are caused by different members of the protozoan family Trypanosomatidae. The most studied member of the family is Trypanosoma brucei, which is spread by tsetse flies and causes African sleeping sickness. Nucleotide metabolism in T. brucei and other trypanosomatids is significantly different from that of mammals and was recognized as a target for chemotherapy already in the 1970–1980s. A more thorough investigation of the nucleotide metabolism in recent years has paved the way for identifying nucleoside analogues that can cure T. brucei brain infections in animal models. Specific features of T. brucei nucleotide metabolism include the lack of de novo purine biosynthesis, the presence of very efficient purine transporters, the lack of salvage pathways for CTP synthesis, unique enzyme localizations, and a recently discovered novel pathway for dTTP synthesis. This review describes the nucleotide metabolism of T. brucei, highlights differences and similarities to other trypanosomatids, and discusses how to exploit the parasite-specific features for drug development.
Separating broad-band site response from single-station seismograms
Authors: Zhu Chuanbin , Cotton Fabrice , Kawase Hiroshi , Bradley Brendon 
Published: May 2023

SUMMARY
In this paper, we explore the use of seismicity data on a single-station basis in site response characterization. We train a supervised deep-learning model, SeismAmp, to recognize and separate seismic site response with reference to seismological bedrock (VS = 3.45 km s−1) in a broad frequency range (0.2–20 Hz) directly from single-station earthquake recordings (features) in Japan. Ground-truth data are homogeneously created using a classical multistation approach—generalized spectral inversion at a total number of 1725 sites. We demonstrate that site response can be reliably separated from single-station seismograms in an end-to-end approach. When SeismAmp is tested at new sites in both Japan (in-domain) and Europe (cross-domain), it achieves the lowest standard deviation among all tested single-station techniques. We also find that horizontal-to-vertical spectral ratio (HVSR) is not the optimal use of single-station recordings. The individual components of each record carry salient information on site response, especially at high frequencies. However, part of the information is lost in HVSR. SeismAmp could lead to improved site-specific earthquake hazard prediction in cases where recordings are available or can be collected at target sites. It is also a convenient tool to remove repeatable site effects from ground motions, which may benefit other applications, for example, improving the retrieval of seismic source parameters. Finally, SeismAmp is trained on data from Japan, future studies could explore transfer learning for practical applications in other regions.
Time-domain Green’s function in poroelastic mediums and its application to 3-D spontaneous rupture simulation
Authors: Li Zhengze , Zhang Haiming 
Published: May 2023

SUMMARYPlenty of studies have suggested that pore fluid may play an important role in earthquake rupture processes. Establishing numerical models can provide great insight into how pore fluid may affect earthquake rupture processes. However, numerical simulation of 3-D spontaneous ruptures in poroelastic mediums is still a challenging task. In this paper, it is found that a closed-form time-domain Green’s function of Biot’s poroelastodynamic model can be constructed when the source frequency and source-field distance are within a certain range. The time-domain Green’s function is validated by being transformed into the frequency domain and comparing with the frequency-domain Green’s functions obtained by former papers. Poroelastic wave propagation phase diagrams for various two-phase poroelastic mediums are then plotted to show the applicable range of frequency and source-field distance for the new time-domain Green’s function. It is shown that the applicable range not only include the frequency and spatial range of concern in seismology but also overlap that in acoustics. Based on the time-domain Green’s function, the boundary integral equations (BIEs) for modelling dynamic ruptures in elastic mediums are extended to fluid-saturated mediums. In the meantime, a functional relationship between the effective stress tensor and the total stress tensor in fluid-saturated mediums is also obtained, which allows us to directly obtain the effective stress by BIEs. The spontaneous rupture processes controlled by the slip-weakening friction law on faults in elastic mediums and in fluid-saturated mediums are compared. It is found that under the same conditions, fluid-saturated rocks are more prone to supershear rupture than dry rocks. This result suggests that pore fluid may promote the excitation of supershear rupture. The poroelastic wave propagation phase diagrams also suggest that simulating a coseismic phase in the real scale requires a certain sample length in laboratories. They also suggest that an undrained governing equation is suitable for seismic wave propagation simulation in poroelastic media.
Gene copy number variation and pediatric mental health/neurodevelopment in a general population
Authors: Zarrei Mehdi , Burton Christie L , Engchuan Worrawat , Higginbotham Edward J , Wei John , Shaikh Sabah , Roslin Nicole M , MacDonald Jeffrey R , Pellecchia Giovanna , Nalpathamkalam Thomas , Lamoureux Sylvia , Manshaei Roozbeh , Howe Jennifer , Trost Brett , Thiruvahindrapuram Bhooma , Marshall Christian R , Yuen Ryan K C , Wintle Richard F , Strug Lisa J , Stavropoulos Dimitri J , Vorstman Jacob A S , Arnold Paul , Merico Daniele , Woodbury-Smith Marc , Crosbie Jennifer , Schachar Russell J , Scherer Stephen W 
Published: May 2023

AbstractWe assessed the relationship of gene copy number variation (CNV) in mental health/neurodevelopmental traits and diagnoses, physical health and cognition in a community sample of 7100 unrelated children and youth of European or East Asian ancestry (Spit for Science). Clinically significant or susceptibility CNVs were present in 3.9% of participants and were associated with elevated scores on a continuous measure of attention-deficit/hyperactivity disorder (ADHD) traits (P = 5.0 × 10−3), longer response inhibition (a cognitive deficit found in several mental health and neurodevelopmental disorders; P = 1.0 × 10−2) and increased prevalence of mental health diagnoses (P = 1.9 × 10−6, odds ratio: 3.09), specifically ADHD, autism spectrum disorder anxiety and learning problems/learning disorder (P’s &lt; 0.01). There was an increased burden of rare deletions in gene-sets related to brain function or expression in brain associated with more ADHD traits. With the current mental health crisis, our data established a baseline for delineating genetic contributors in pediatric-onset conditions.