bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cell‐Based Therapies for Degenerative Musculoskeletal Diseases
Authors: Yin Pengbin , Jiang Yuheng , Fang Xuan , Wang Daofeng , Li Yi , Chen Ming , Deng Hao , Tang Peifu , Zhang Licheng 
Published: May 2023

AbstractDegenerative musculoskeletal diseases (DMDs), including osteoporosis, osteoarthritis, degenerative disc disease, and sarcopenia, present major challenges in the aging population. Patients with DMDs present with pain, functional decline, and reduced exercise tolerance, which result in long‐term or permanent deficits in their ability to perform daily activities. Current strategies for dealing with this cluster of diseases focus on relieving pain, but they have a limited capacity to repair function or regenerate tissue. Cell‐based therapies have attracted considerable attention in recent years owing to their unique mechanisms of action and remarkable effects on regeneration. In this review, current experimental attempts to use cell‐based therapies for DMDs are highlighted, and the modes of action of different cell types and their derivatives, such as exosomes, are generalized. In addition, the latest findings from state‐of‐the‐art clinical trials are reviewed, approaches to improve the efficiency of cell‐based therapies are summarized, and unresolved questions and potential future research directions for the translation of cell‐based therapies are identified.
Surface‐Mediated Spin Locking and Thermal Unlocking in a 2D Molecular Array
Authors: Cojocariu Iulia , Windischbacher Andreas , Baranowski Daniel , Jugovac Matteo , Ferreira Rodrigo Cezar de Campos , Doležal Jiří , Švec Martin , Zamalloa‐Serrano Jorge Manuel , Tormen Massimo , Schio Luca , Floreano Luca , Dreiser Jan , Puschnig Peter , Feyer Vitaliy , Schneider Claus M. 
Published: May 2023

AbstractMolecule‐based functional devices may take advantage of surface‐mediated spin state bistability. Whereas different spin states in conventional spin crossover complexes are only accessible at temperatures well below room temperature, and the lifetimes of the high‐spin state are relatively short, a different behavior exhibited by prototypical nickel phthalocyanine is shown here. Direct interaction of the organometallic complex with a copper metal electrode mediates the coexistence of a high spin and a low spin state within the 2D molecular array. The spin state bistability is extremely non‐volatile, since no external stimuli are required to preserve it. It originates from the surface‐induced axial displacement of the functional nickel cores, which generates two stable local minima. Spin state unlocking and the full conversion to the low spin state are only possible by a high temperature stimulus. This spin state transition is accompanied by distinct changes in the molecular electronic structure that might facilitate the state readout at room temperature, as evidenced by valence spectroscopy. The non‐volatility of the high spin state up to elevated temperatures and the controllable spin bistability render the system extremely intriguing for applications in molecule‐based information storage devices.
Components of agricultural productivity change: Replication of US evidence and extension to the EU
Authors: Wimmer Stefan , Dakpo K Hervé 
Published: May 2023

AbstractIncreasing agricultural productivity is a policy priority in many countries. O'Donnell (Am. J. Agric. Econ. 94(4): 873–890, 2012) decomposed productivity change in US agriculture using a Lowe total factor productivity (TFP) index. We replicate the original study, assess its robustness to alternative TFP indices, and extend the analysis to EU agriculture. We consistently find that productivity growth in US agriculture is mainly driven by technical progress. In EU agriculture, TFP growth is less pronounced, and both technical change and efficiency change contribute to productivity changes. In both US and EU agriculture, the magnitude of measured productivity change varies across indices, highlighting the need to rely on multiple indices for robust policy recommendations.
Translating critical reflection into collective action: The mediating role of Asian American racial identity ideological values
Authors: Saavedra J. Abigail , Yoo Hyung Chol 
Published: May 2023

AbstractThroughout U.S. history, Asian Americans engaged in various forms of collective action to challenge systems of oppression. Despite this, few studies challenge the stereotype that Asian Americans are apolitical and uninterested in collective action and focus on psychological correlates of Asian Americans' collective action. Collective action may be motivated by critical reflection on racism and inequality, which may induce shifts in racial identity ideological values that lead Asian Americans to align with minoritized groups. The current study examines whether Asian American racial identity ideological values—specifically, Asian American Unity, Interracial Solidarity, and Transnational Critical Consciousness—help explain why critical reflection is linked to collective action among Asian Americans. Multiple mediation analyses suggested that, among Asian American college students in the Southwest United States (N = 272), beliefs about Interracial Solidarity and Asian American Unity mediated the relationship between critical reflection (i.e., Critical Reflection on Racism and Perceived Inequality) and collective action (i.e., Support for Black Lives Matter and Sociopolitical Participation). Transnational Critical Consciousness did not mediate the relationship between critical reflection and collective action. This study highlights how Asian American unity and interracial solidarity beliefs underlie Asian Americans' critical reflection and collective action.
Making sense of the parenting ‘soft/hard split’
Authors: Brown Jenny 
Published: May 2023

AbstractThis paper explores the common parenting style tension around nurture versus limit‐setting often evident when working with families with a symptomatic child. Firstly it will delve into the parenting ‘soft/hard split’ with an overview of the literature on parenting styles. Next, it summarises the appearance of this phenomenon in the family therapy literature during its formative days, noting how Bowen, Minuchin, Haley, MRI (Bateson), and the Milan associates respond to this parent presentation in their approaches. Next, the paper outlines recent iterations of these family therapy interventions. An expanded discussion follows on Bowen theory's understanding of the parenting tension triangle. The article then outlines elements of the author's qualitative research study of parents' experience of adolescents' mental health treatment where the ‘soft/hard split’ emerged as a repeating theme. Finally, a clinical intervention based on Bowen theory, the Parent Hope Project, is outlined for how it addresses the parenting ‘soft/hard split.’ The goal is to contribute to understanding this phenomenon and its implications for clinical practice.
More than just pain?! A systemic compass for working with people with chronic pain
Authors: Bernaerts Lisa 
Published: May 2023

AbstractOver one in four people in Belgium experience severe physical pain. One in 10 people develop chronic pain every year worldwide. Treatment of chronic pain is based on the biopsychosocial model. Scientific views state, among other things, that pain is a threat to the social self, which is an interesting point of entry for (mental) health‐care providers. Conversations with people with chronic pain are always about more than just their pain; they are interesting and cover a lot of ground. Talking about feelings of being hard done‐by, clarifying the complexity of the situation, examining the body as an autonomous entity, offering psychoeducation as a hypothesis, and a general attitude of not‐knowing form a compass that allows us to attune to the patient and not take up an advisory position. Living with chronic pain requires negotiating with the outside world, being allowed to care for and consider the body, and being allowed to differ from the norm and still fit in enough in a world where the body is just a background figure. An identity transformation and the effects of trauma are described. We meet Eddy and Anne, both dealing with chronic pain, who bring theory alive. The author gives an insight into her personal search and struggles as a psychotherapist introducing systemic psychotherapy in chronic pain patients.
Goethite (α‐FeOOH) photocatalytic activity at natural concentrations by the addition of H2O2 at neutral pH and the simultaneous presence of fluoride and bicarbonate
Authors: Alvear‐Daza John J. , Sanabria Janeth , Castaño‐Rodriguez Victor A. , Correa‐Betancourt Alejandra , Binet Silvia , Sánchez Francisco H. , Muñoz‐Medina Guillermo A. , Gutiérrez‐Zapata Héctor M. , Pizzio Luis R. , Rengifo‐Herrera Julián A. 
Published: May 2023

AbstractThe effect of the simultaneous presence of fluoride (0.15–1.2 mg L−1), bicarbonates (83.6–596 mg L−1), and synthesized goethite (0.3 mg L−1) at typical concentrations often found in groundwater samples was evaluated on the degradation of 2,4‐dichlorophenoxyacetic acid (2,4‐D) at pH 6.9 under simulated sunlight irradiation (300 W m−2) and H2O2 concentrations of 10 mg L−1. The 2,4‐D removal was strongly enhanced by the presence of fluoride. F− could modify the surface of iron (hydr)oxide, leading to the formation of surface Fe–F bonds benefiting the formation of free •OH, producing upward band bending, reducing the electron‐hole recombination, and enhancing the electron transfer to H2O2. On the other hand, bicarbonate may react with •OH generating CO3−• species that could participate in pollutant oxidation, while solar light‐induced H2O2 photolysis also played an important role in removing 2,4‐D. These findings suggest that tuning of iron (hydr)oxides by fluoride could take place in real groundwater, generating photocatalysts with a high activity that could participate, by adding H2O2, in the enhancement of sunlight photoinduced natural abiotic processes for pollutant abatement.
New Zealand's media and the crisis in the ocean: News norms and scientific urgency
Authors: Armoudian Maria , Stevens Grace , Stephenson Fabrice , Ellis Joanne 
Published: May 2023

Abstract

To date, no studies have analysed New Zealand's media coverage of ocean‐related threats, potential harms, or sources used for their coverage. This is concerning given that marine media coverage is linked to public support, awareness of conservation issues, and policymaking.
This research helps fill this gap, examining all ocean‐related articles 2 weeks before and after the 2019 Intergovernmental Panel on Climate Change (IPCC) report's release on the oceans and cryosphere.
It first analyses the media's reporting of threats, potential harms arising from the threats, and the sources on whom journalists relied and gave voice, then it tests a report of global significance for influence on reportage.
Second, it examines whether the threats covered by media align with scientists' main concerns (from the IPCC report and a survey of New Zealand scientists).
In contrast to previous studies on media sources for environmental conservation, this study found that journalists in New Zealand relied considerably on scientists as key sources. However, it found that coverage of ocean‐related threats did not match scientists' main concerns.
Finally, the research found that the IPCC report appeared to influence coverage in two areas: reporting on threats to island nations, and multiple potential harms. Otherwise, New Zealand's media covered the IPCC report as any other news item, reporting on it and then shifting to other matters.
The lack of coverage on primary scientific concerns and that a globally significant momentous report did not dramatically impact the marine media landscape is problematic for conservation of ocean habitats, species, and broader environmental and societal outcomes owing to poor understandings by policymakers and the public, which can lead to inaction and policy failures.
The potential reasons and solutions to advance communication of marine conservation issues for a more educated and mobilized public are explored.
Sign‐indefinite static output feedback Nash strategy for mean‐field stochastic systems
Authors: Mukaidani Hiroaki , Sagara Muneomi , Xu Hua 
Published: May 2023

AbstractWe study static output feedback (SOF) Nash strategies for mean‐field stochastic systems. The study assumes a linear‐quadratic form of the cost functional, but the sign of the weighting matrix is indefinite. Moreover, the worst‐case disturbances are assumed to be of unconventional SOF form leading to a saddle‐point equilibrium. First, after defining the problem for the single‐player case, the necessary conditions for the existence of saddle‐point equilibrium are established. Then, we consider Nash games for mean‐field stochastic systems. Note that the cost functional associated with the mean‐field term is assumed to be of SOF form. We establish the necessary conditions for the Nash equilibrium using the cross‐coupled stochastic algebraic matrix equations (CCSAME). A new decomposition algorithm is proposed to avoid the challenges of solving high‐dimensional CCSAMEs. We also apply weakly coupled systems theory to propose a decentralized approximated reduced‐order Nash strategy. The degree of cost degradation of the decentralized strategy compared with the centralized strategy is derived more accurately than existing results. Finally, we illustrate the usefulness and effectiveness of the proposed strategy set through numerical examples.
GalvAnalyze: Streamlining Data Analysis of Galvanostatic Battery Cycling
Authors: McNulty Rory C. , Rier Lukas 
Published: May 2023

AbstractWe present GalvAnalyze, a software tool developed in Python, that processes data collected using a variety of battery cyclers and creates a set of outputs that greatly reduce the inefficiencies associated with manual or semi‐manual analysis of galvanostatic cycling data. An experiment is carried out by 10 participants with varying degrees of experience processing galvanostatic cycling data, enabling quantitative analysis of the processing time benefit that GalvAnalyze provides. The functionality of GalvAnalyze includes handling data where the applied current density varies, separating the data into individual charge‐discharge cycle pairs, and producing hysteresis plots using a simple graphical user interface. The executable can be downloaded at http://www.thenamilab.com/ and is built to be accessible, with no prior coding expertise required. In the interest of transparency, and to allow future contributions to the functionality of GalvAnalyze by the wider community, the source code can be found on GitHub (https://github.com/LukasRier/GalvAnalyze).
Comparison of likelihood penalization and variance decomposition approaches for clinical prediction models: A simulation study
Authors: Lohmann Anna , Groenwold Rolf H. H. , van Smeden Maarten 
Published: May 2023

AbstractLogistic regression is one of the most commonly used approaches to develop clinical risk prediction models. Developers of such models often rely on approaches that aim to minimize the risk of overfitting and improve predictive performance of the logistic model, such as through likelihood penalization and variance decomposition techniques. We present an extensive simulation study that compares the out‐of‐sample predictive performance of risk prediction models derived using the elastic net, with Lasso and ridge as special cases, and variance decomposition techniques, namely, incomplete principal component regression and incomplete partial least squares regression. We varied the expected events per variable, event fraction, number of candidate predictors, presence of noise predictors, and the presence of sparse predictors in a full‐factorial design. Predictive performance was compared on measures of discrimination, calibration, and prediction error. Simulation metamodels were derived to explain the performance differences within model derivation approaches. Our results indicate that, on average, prediction models developed using penalization and variance decomposition approaches outperform models developed using ordinary maximum likelihood estimation, with penalization approaches being consistently superior over the variance decomposition approaches. Differences in performance were most pronounced on the calibration of the model. Performance differences regarding prediction error and concordance statistic outcomes were often small between approaches. The use of likelihood penalization and variance decomposition techniques methods was illustrated in the context of peripheral arterial disease.
Pan‐cancer analysis of oncogenic role of insulin‐like growth factor‐binding proteins and validation in ovarian cancer
Authors: Tan Wei , Zhang Jie , Deng Zhimin , Dai Fangfang , Tang Lujia , Hu Wei , Liu Hua 
Published: May 2023

AbstractBackgroundNumerous studies have shown that the insulin‐like growth factor (IGF) pathway is highly associated with tumor initial and progression in several tumors. However, compared with IGF1/1R and IGF2/2R, insufficient studies have focused on IGF‐binding proteins (IGFBPs).MethodsThe GDC TCGA and GTEx data of 33 cancers, TCGA pan‐cancer immune phenotypes, tumor mutation burdens, and the copy number alterations of IGFBPs were extracted. Next, the prognostic value of IGFBPs was analyzed based on a univariate Cox analysis. Additionally, the ESTIMATE algorithm was used to calculate stromal and immune scores and tumor purity, and the CIBERSORT algorithm was used to estimate tumor‐infiltrating immunocyte levels. Ultimately, the correlation between IGFBP expression and cancer hallmark pathways was estimated with a Spearman analysis.ResultsThe expression of IGFBPs was differentially expressed and correlated with prognosis in specific cancers. IGFBPs may operate as biological markers for carcinogenesis and progression and as prognostic biomarkers. Additionally, IGFBP5 has been proved that promotes the invasion and migration of ovarian cancer.ConclusionsIn general, IGFBPs can serve as predictable biomarkers and potential therapeutic targets for specific tumors. Our results could provide underlying targets for the design of laboratory experiments to elucidate the mechanism of IGFBPs in cancers and identify IGFBP5 as a prognostic factor in ovarian cancers.
Patient‐reported quality of life in adolescents and young adults with cancer who received radiation therapy
Authors: Corrigan Kelsey L. , Reeve Bryce B. , Salsman John M. , Siembida Elizabeth J. , Smith Grace L. , Swartz Maria C. , Lee Kamaria L. , Afridi Faraz , Andring Lauren M. , Bishop Andrew J. , Gunther Jillian R. , Livingston J. Andrew , Peterson Susan K. , Roth Michael 
Published: May 2023

AbstractBackgroundRadiation therapy (RT) is a common treatment for adolescents and young adults (AYAs, 15–39 years old) with cancer; however, it may cause toxicities that affect health‐related quality‐of‐life (HRQOL). Thus, we assessed HRQOL in AYAs before, during, and after RT.MethodsWe identified 265 AYAs who completed HRQOL PROMIS® surveys before (n = 87), during (n = 84), or after (n = 94) RT. Higher PROMIS® score represents more of the concept. Mean scores were compared to the general US population and minimally important differences (MIDs) were used to evaluate the impact of cancer on HRQOL. Linear regression modeling was used to evaluate the effect of clinical and demographic factors on PROMIS scores.ResultsMedian [IQR] age was 26 [20–31] years. Cancer types varied; most had sarcoma (26%) or CNS malignancy (23%). Compared to the general US population, the before RT cohort had worse anxiety (mean score 55.2 vs. 50, MID 3, p < 0.001) and the during RT cohort had worse global physical health (mean score 44.9 vs. 50, MID 5, p < 0.001). In the during RT cohort, patients with regional/distant disease had significantly worse pain (B = 15.94, p < 0.01) and fatigue (B = 14.20, p = 0.01) than patients with localized disease. In the after RT cohort, adolescents (15–18 years) and young adults (26–39 years) had worse global physical health (B = ‐6.87, p < 0.01, and B = ‐7.87, p < 0.01, respectively) and global mental health (B = ‐6.74, p < 0.01, and B = ‐5.67, p = 0.01, respectively) than emerging adults (19–25 years).ConclusionsAYAs with cancer receiving RT experience impairments in various domains of HRQOL. Advanced cancer stage may contribute to poorer short‐term HRQOL and developmental stage may contribute to differing long‐term HRQOL.
Adherence and contamination in a 1‐year physical activity program in childhood cancer survivors: A report from the SURfit study
Authors: Jung Ruedi , Zürcher Simeon J. , Schindera Christina , Braun Julia , Deng Wei Hai , von der Weid Nicolas X. , Rueegg Corina S. , Kriemler Susi 
Published: May 2023

AbstractPurposeMeeting intervention requirements is crucial in behavioral trials. We examined patterns and predictors of physical activity (PA) adherence and contamination in a 1‐year individualized randomized controlled PA behavioral intervention in childhood cancer survivors (CCS).MethodsCCS aged ≥16 at enrolment, <16 at diagnosis, and ≥5 years in remission were identified from the Swiss Childhood Cancer Registry. We asked participants randomized to the intervention group to perform an additional ≥2.5 h of intense PA/week and controls to continue as usual. Adherence to the intervention was assessed by online diary (adherent if ≥2/3 of individual PA goal reached) and contamination for the control group by pre‐ and post‐questionnaire including PA levels (contaminated if >60 min increase/week in PA). Predictors of adherence/contamination including quality of life (36‐Item Short Form Survey) were assessed by questionnaire. We used logistic (control group) and mixed logistic regression models (exercise group) to estimate predictors of study adherence and contamination.ResultsOne hundred and forty‐four survivors (30.4 ± 8.7 years old, 43% females) were included. Adherence was 48% (35/73) in the intervention group, while 17% (12/71) of controls contaminated group allocation. Predictors for PA adherence were female sex (OR 2.35, p = 0.03), higher physical (OR 1.34, p = 0.01) and mental quality of life (OR 1.37, p = 0.001), and week into the intervention (OR 0.98, p < 0.001). Clear differences in PA behavior of adherent and non‐adherent participants were seen from week four. No significant predictors for contamination were found for controls.ConclusionAdherence to PA behavior interventions remain challenging in both groups. Further long‐term trials should consider intense motivational support within the first month, more detailed data collection for the control group, adjustments to power calculations and other study designs to minimize non‐adherence and contamination.