bluuebunny/crossref_metadata_2025_split huggingface dataset:
Đánh giá tác dụng của nhĩ châm kết hợp viên “ích khí an thần - HVY” trong điều trị mất ngủ thể tâm tỳ hư
Authors: Đỗ Thị Huyền , Trần Đức Hữu 
Published: July 2023

Mục tiêu: Đánh giá tác dụng của nhĩ châm kết hợp viên Ích khí an thần – HVY trong điều trị mất ngủ thể tâm tỳ hư trên lâm sàng.
Đối tượng và phương pháp nghiên cứu: Nghiên cứu tiến cứu, so sánh trước và sau điều trị có đối chứng trên 60 bệnh nhân mất ngủ thể tâm tỳ hư, chia làm 2 nhóm: 30 bệnh nhân nhóm nghiên cứu được điều trị bằng nhĩ châm kết hợp uống thuốc Ích khí an thần – HVY, và 30 bệnh nhân nhóm đối chứng được điều trị bằng nhĩ châm. Các bệnh nhân được khám lâm sàng, đánh giá theo thang điểm PSQI tại các thời điểm D0, D10, D20. So sánh giữa 2 nhóm tại các thời điểm tương ứng.
Kết quả: Hiệu quả giấc ngủ sau 20 ngày điều trị ở nhóm nghiên cứu tăng, sự khác biệt so với nhóm đối chứng có ý nghĩa thống kê với p < 0,05. Không phát hiện tác dụng không mong muốn của phương pháp điều trị trên lâm sàng.
Kết luận: Phương pháp nhĩ châm kết hợp dùng thuốc Ích khí an thần – HVY có tác dụng cải thiện chất lượng giấc ngủ của người bệnh hơn là chỉ điều trị bằng nhĩ châm.
Đánh giá tác dụng của điện châm và tư vấn dinh dưỡng trong điều trị giảm béo ở bệnh nhân béo phì
Authors: Nguyễn Vinh Nam , Trần Thị Thu Vân , Nguyễn Văn Hải 
Published: July 2023

Mục tiêu: Đánh giá tác dụng của điện châm và tư vấn dinh dưỡng trong điều trị bệnh nhân béo phì và theo dõi các tác dụng không mong muốn của phương pháp trong quá trình điều trị.
Đối tượng và phương pháp nghiên cứu: Nghiên cứu của thử nghiệm lâm sàng so sánh trước sau điều trị sử dụng điện châm kết hợp can thiệp dinh dưỡng với liệu trình kéo dài 20 ngày trên 65 bệnh nhân Bệnh viện Tuệ Tĩnh từ tháng 5/2021 đến tháng 2/2022. BN được can thiệp bằng phương pháp châm cứu dựa theo phác đồ huyệt có sẵn kết hợp với tư vấn dinh dưỡng theo tháp dinh dưỡng của Viện Dinh Dưỡng Quốc Gia năm 2020.
Kết quả: Qua nghiên cứu cho thấy, sau điều trị chỉ số BMI, vòng bụng, vòng mông, WHR và cân nặng giảm có ý nghĩa thống kê so với trước điều trị và nhóm tuân thủ chế độ dinh dưỡng tốt có hiệu suất cải thiện cao hơn so với nhóm còn lại có ý nghĩa thống kê trên hầu hết các chỉ số. Kết quả chung đánh giá dựa trên đáp ứng giảm cân nặng cho thấy, nhóm bệnh nhân đáp ứng tốt (42,42%) cao hơn so với nhóm tuân thủ chế độ dinh dưỡng không tốt (34,38%)
Kết luận: Điện châm và tư vấn dinh dưỡng có tác dụng trong điều trị giảm béo ở bệnh nhân béo phì, phương pháp thay đổi các chỉ số BMI, WHR, các chỉ số cận lâm sàng và gây ít tác dụng không mong muốn trên bệnh nhân.
Chiết xuất, phân lập một số hợp chất từ cây Thài lài trắng (Commelina diffusa Burm.f.)
Authors: Nguyễn Xuân Tùng , Vũ Đức Lợi , Lê Hồng Dương , Nguyễn Thị Vân Anh 
Published: July 2023

Mục tiêu: Chiết xuất, phân lập một số hợp chất từ cây Thài lài trắng (Commelina diffusa Burm.f.)
Đối tượng và phương pháp: Cây Thài lài trắng được ngâm chiết bằng MeOH, sau đó cắn MeOH được lắc phân đoạn với n-hexan và ethyl acetat. Sử dụng các phương pháp sắc ký thích hợp để phân lập ba hợp chất sạch, ký hiệu 1-3. Sau đó, đo nhiệt độ nóng chảy, phổ khối (MS), phổ cộng hưởng từ hạt nhân (1H-NMR, 13C-NMR, DEPT) để xác định cấu trúc hóa học của chúng.
Kết quả: Ba hợp chất được xác định là stigmasterol (1), daucosterol (2) và quercitrin (3). Trong đó, hợp chất 3 lần đầu tiên được phân lập từ loài thực vật này.
Kết luận: Nghiên cứu đã chiết xuất, phân lập được 3 hợp chất từ cắn chiết ethyl acetate của cây Thài lài trắng (Commelina diffusa Burm.f.), gồm stigmasterol (1), daucosterol (2) và quercitrin (3).
PROSES ADAPTASI PENGURUS BADAN USAHA MILIK DESA DI ERA PANDEMI COVID-19 DALAM MENINGKATKAN KESEJAHTERAAN MASYARAKAT DI DESA KAMBUNO DAN ARA KABUPATEN BULUKUMBA
Authors: Sosiawan Aryo , Nain Umar 
Published: July 2023

For the sustainability of Village Owned Enterprises(BUMDesa) in the Covid-19 Pandemic Era, the BumdesManagement carried out an adaptation process. This study aims to describe the adaptation process ofBumdesa Management in the Covid-19 Pandemic Era, in improving the welfare of the people in Kambunoand Ara Villages, Bulukumba Regency. This type of research uses a qualitative approach with case studies.Informants were selected through a purposive sampling technique, which consisted of elements from thevillage head, Bumdes management, community members as beneficiaries of Bumdes at 2 research loci. Thedata collection techniques used were observation, in-depth interviews (indept interviews), and Focus GroupDiscussions(FGD). Data analysis was carried out through three stages, starting from data reduction, datapresentation and drawing conclusions and verification. The results of the study indicate that there are 3aspects of the adaptation process carried out by the Bumdesa Management, including: (1). Social aspects, providing limited basic food assistance to the community, due to the lack of budget availability for Bumdes;(2). The economic aspect, by closing certain business units so that there is a decrease in the income of theBumdes business unit and the community during the Covid-19 Pandemic; and (3). the health aspect, providingassistance to improve community nutrition, in the form of brown rice and milk for pregnant women, such asin Kambuno Village. Meanwhile in Ara, the focus is on improving environmental hygiene through processingplastic waste. However, the adaptation process in social, economic and health aspects has not been optimalin improving community welfare due to the lack of available budget in Bumdes.
Hacia una financiación verde y digital del Tercer Sector a través de las criptomonedas sociales complementarias. Aspectos fiscales
Authors: Gómez Álvarez Juan Jesús , Luque Mateo Miguel Angel 
Published: July 2023

El Tercer Sector ha sido desde sus inicios un agente económico y social dependiente de recursos económicos externos. Junto a las formas tradicionales de financiación, como las donaciones o el mecenazgo, han aparecido nuevos sistemas basados en la tecnología blockchain, como son las criptomonedas. Sus características y amplias funcionalidades dotan de flexibilidad, simplicidad y seguridad a los intercambios y prestaciones de bienes y servicios. En los últimos años ha proliferado su uso, haciéndolas accesible a una gran parte de la población. No obstante, en algunos casos las criptomonedas tradicionales se están utilizando como instrumento de especulación, lo que está teniendo importantes efectos negativos, no solo en cuando a la justicia social, sino también sobre el medio ambiente, debido a su sistema de creación basado en el minado.
Frente a este modelo, están adquiriendo una enorme popularidad las criptomonedas sociales, que por sus características y principios pueden integrarse en las relaciones económico-financieras de las entidades del Tercer Sector, sin tener un impacto sobre nuestro entorno. Especial consideración merece la denominada ?1, “Juna” o Moneda Libre, por el nuevo paradigma que plantea, al no estar respaldada ni por bienes o servicios, ni por moneda fiduciaria. En el presente trabajo se analizan las repercusiones tributarias de su uso, así como la idoneidad de su utilización como sistema complementario de financiación digital y verde para el Tercer Sector.
Emergency Remote Teaching Student Responses to Intensive versus Extensive Course Modalities during the Pandemic
Authors: Ennis Michael , Unterkofler Dietmar , Bonetto Elena 
Published: July 2023

Covid-19 forced university language programs to reevaluate and revolutionize their teaching practices. While in the years preceding the pandemic, many administrators and practitioners were reluctant to embrace blended or fully online language courses, these teaching/learning modalities quickly became the “new normal”. To monitor the efficacy of the courses offered remotely during the 2020/21 academic year, the Language Center of Libera Università di Bolzano administered a series of surveys to students – in addition to the data we routinely collect by way of our “big data” approach to language curriculum monitoring. These courses were offered both in an “extensive” and an “intensive” format. The responses to the surveys – in combination with course enrollment, participation, and completion data – offer an opportunity to investigate students’ attitudes and behavior toward remote teaching and learning, but also to compare intensive language teaching and learning with extensive language teaching and learning, a topic which has not received sufficient attention in the literature to-date. Notwithstanding the well-documented challenges associated with “emergency remote teaching”, we observed many positive experiences and outcomes. Our data is being used to inform decisions regarding which courses will continue to be taught fully or partially online in the years to come.
Apprendimento digitale dell’italiano L2. Un approccio ludico
Authors: Gilardoni Silvia , Cerizza Alessandra 
Published: July 2023

Digital Learning of Italian as a Foreign Language: A Playful Approach. Foreign language teaching has been more challenging than ever since the beginning of the Covid-19 health emergency. The transition from face-to-face to remote teaching has raised a series of problems for all stakeholders involved in foreign language teaching training, with particular reference to motivation and the management of the interaction between teachers and students, especially when it came to the assessment of skills acquired in this particular environment. The present contribution showcases a series of teaching activities and examples taken from a course of Italian as a second language, with a view to highlighting how digital tools and technologies can be leveraged with the aim of increasing interaction, involvement, and participation of learners, through a playful approach to task-based activities. A brief presentation of the methodological approach and the digital learning tools is complemented by authentic examples of activities that were implemented in the academic year 2020/21 at Università Cattolica del Sacro Cuore of Milano.
Selection of Suitable Genotypes Based on Physiological and Morphological Traits in Rapeseed (Brassica napus L.)
Authors: Sadeghizadeh Malihe 
Published: July 2023

Aims: Rapeseed (Brassica napus L.) as one of the most important oilseeds in the world, has a special role in cultivation and plant breeding research. Especially, the properties of rapeseed oil compounds, which have high oleic acid, antioxidant and positive effects on cholesterol, blood sugar control, blood pressure and cancer, make it one of the healthiest and most important edible oils in the world and an alternative to use Other vegetable oils have been introduced in recent years. Evaluation of different genotypes of Rapeseed in terms of different traits and selection of the most appropriate genotypes can be effective in realizing the goals of plant breeding.
Study Design: In order to conduct the experiment, a randomized complete block design (RCBD) was used in three replications.
Place and Duration of Study: This study was conducted in Varamin region of Iran in 2019-2020.
Methodology: Each experimental plot had 4 rows of cultivation at a distance of 50 cm. The seeds were planted at a distance of 10 cm from each other and all steps such as watering and weeding were done regularly and manually.
Results: The results of analysis of variance at the level of 0.01 indicated that the evaluated genotypes have significant differences in terms of all traits except the number of grains in the pod. In the means comparison of the traits, grain yield and oil percentage traits, which were selected as the most important traits, the Licord genotype was selected as the most favorable genotype. Based on the correlation analysis between the traits, the trait of grain yield had a positive and significant correlation with the traits of thousand grain weight, number of pods in the main stem, pod weight, days to flowering and oil percentage. Based on analysis of the main components, the first five components accounted for more than 74% of the variance of the total data. The drawn polygon diagram also identified Licord, Hyola-401, SLM046, Modena and Option 500 genotypes as desirable genotypes.
Conclusion: Non-invasive independent predictors for screening esophageal varices may decrease medical as well as financial burden, hence improving the management of cirrhotic patients. These predictors, however, need further work to validate reliability.
Analysis of Phenolic Compounds in Nicotiana tabacum Based on Aqueous Two-Phase Extraction Coupled with Liquid Chromatography
Authors: Wang Hua , Zeng Lina , Ding Hui 
Published: July 2023

Background: Phenolic compounds in Nicotiana tabacum L. have anti-tumor, antibacterial, anti-inflammatory, and other pharmacological effects. Therefore, either to optimize the utilization of plant resources or to reduce the physiological harm caused by cigarette, it is necessary to separate and analyze the phenolic compounds in Nicotiana tabacum.
Aim: To develop a protocol for extraction and analysis of phenolic compounds in Nicotiana tabacum. The method based on aqueous two-phase extraction (ATP) should provide a solid experimental basis for future large-scale medical industrial extraction.
Results: Five of phenolic compounds in Nicotiana tabacum including catechol, caffeic acid, coumarin, rutin, and quercetin were extracted with the developed ATP method and analyzed by the optimized liquid chromatography method simultaneously. In the concentration range of 10-200 µg/mL, the linear correlation coefficients of calibration curve for five compounds were all greater than 0.999. The developed ATP extraction method employed 70% acetonitrile water solution as the extractant. The ammonium sulphate was selected as the preferred phase separation salt. The extraction efficiencies of five phenolic compounds were all more than 90%. In concrete sample, the concentrations of five compounds were determined based on acetonitrile/salt ATPE system,
Conclusion: Analysis of phenolic compounds in Nicotiana tabacum was achieved based on acetonitrile/ammonium sulphate ATP extraction coupled with liquid chromatography. The developed ATP extraction protocol employed 70% acetonitrile water solution as the extractant. The ammonium sulphate was selected as the preferred phase separation salt. The accuracy and precision were satisfied. The protocol developed in this study is expected to be applied in medical industry.
NCSTN In-Frame Deletion in Maltese Patients With Hidradenitis Suppurativa
Authors: Mintoff Dillon , Pace Nikolai Paul , Borg Isabella 
Published: July 2023

ImportanceHidradenitis suppurativa (HS) is a complex trait that has a monogenic etiology in a subset of patients. Variation in genes that encode proteins of the γ secretase complex, particularly NCSTN, account for few patients who exhibit familial forms of HS. Thus far, extensive genotype-phenotype correlations have been lacking.ObjectiveTo establish the prevalence of the NCSTN:c.671_682del variant and explore potential genotype-phenotype associations in an ethnically Maltese HS cohort.Design, Setting, and ParticipantsThis cross-sectional study conducted from December 2021 to September 2022 included patients 18 years or older with a diagnosis of HS as defined by recurrent nodules, abscesses, and/or draining tunnels in typical (axilla, breast, groin, buttock, thighs, and inframammary folds) and less typical (scalp, ear pinnae, neck, arms, antecubital fossae) sites who were recruited from the sole national dermatology reference center servicing the Maltese archipelago. Clinical examination and targeted genetic analysis for an NCSTN deletion that was originally identified through whole-exome sequencing in a family with multigenerational disease were performed.ExposureRecruited patients were phenotyped and genotyped for the NCSTN:c.671_682del variant.Main Outcome and MeasuresTo determine the prevalence of the NCSTN:c.671_682del variant and establish possible genotype-phenotype associations in the ethnically Maltese HS cohort.ResultsA total of 113 patients with HS (56 women [49.6%]) met the inclusion criteria and were enrolled in this study. The median age of disease onset was 18 years (range, 7-62 years), and the median International Hidradenitis Suppurativa Severity Score System score was 4.39 (range, 1.0-64.0). The NCSTN variant was identified in the heterozygous state in 14 patients (12.4%) from 5 unrelated, nonconsanguineous families of Maltese ethnicity. The variant was not identified in an ethnically matched reference genomic data set of disease-free individuals. Variant carriers manifested HS symptoms earlier and were more likely to exhibit a distinctive HS phenotype, which was characterized by involvement of the scalp, neck, torso, and antecubital fossae. Despite manifesting similar clinical disease severity, variant carriers were more likely to require treatment with adalimumab.Conclusions and RelevanceThe results of this cross-sectional study suggest that monogenic variation in NCSTN is associated with HS in a subset of patients who have a distinct, atypical phenotype.
Low-Dose Aspirin and the Risk of Stroke and Intracerebral Bleeding in Healthy Older People
Authors: Cloud Geoffrey C. , Williamson Jeff D. , Thao Le Thi Phuong , Tran Cammie , Eaton Charles B. , Wolfe Rory , Nelson Mark R. , Reid Christopher M. , Newman Anne B. , Lockery Jessica , Fitzgerald Sharyn M. , Murray Anne M. , Shah Raj C. , Woods Robyn L. , Donnan Geoffrey A. , McNeil John J. 
Published: July 2023

ImportanceLow-dose aspirin has been widely used for primary and secondary prevention of stroke. The balance between potential reduction of ischemic stroke events and increased intracranial bleeding has not been established in older individuals.ObjectiveTo establish the risks of ischemic stroke and intracranial bleeding among healthy older people receiving daily low-dose aspirin.Design, Setting, and ParticipantsThis secondary analysis of the Aspirin in Reducing Events in the Elderly (ASPREE) randomized, double-blind, placebo-controlled trial of daily low-dose aspirin was conducted among community-dwelling people living in Australia or the US. Participants were older adults free of symptomatic cardiovascular disease. Recruitment took place between 2010 and 2014, and participants were followed up for a median (IQR) of 4.7 (3.6-5.7) years. This analysis was completed from August 2021 to March 2023.InterventionsDaily 100-mg enteric-coated aspirin or matching placebo.Main Outcomes and MeasuresStroke and stroke etiology were predetermined secondary outcomes and are presented with a focus on prevention of initial stroke or intracranial bleeding event. Outcomes were assessed by review of medical records.ResultsAmong 19 114 older adults (10 782 females [56.4%]; median [IQR] age, 74 [71.6-77.7] years), 9525 individuals received aspirin and 9589 individuals received placebo. Aspirin did not produce a statistically significant reduction in the incidence of ischemic stroke (hazard ratio [HR], 0.89; 95% CI, 0.71-1.11). However, a statistically significant increase in intracranial bleeding was observed among individuals assigned to aspirin (108 individuals [1.1%]) compared with those receiving placebo (79 individuals [0.8%]; HR, 1.38; 95% CI, 1.03-1.84). This occurred by an increase in a combination of subdural, extradural, and subarachnoid bleeding with aspirin compared with placebo (59 individuals [0.6%] vs 41 individuals [0.4%]; HR, 1.45; 95% CI, 0.98-2.16). Hemorrhagic stroke was recorded in 49 individuals (0.5%) assigned to aspirin compared with 37 individuals (0.4%) in the placebo group (HR, 1.33; 95% CI, 0.87-2.04).Conclusions and RelevanceThis study found a significant increase in intracranial bleeding with daily low-dose aspirin but no significant reduction of ischemic stroke. These findings may have particular relevance to older individuals prone to developing intracranial bleeding after head trauma.Trial RegistrationISRCTN.org Identifier: ISRCTN83772183
Transmission probability filter optimization for Agility MLC in Monaco treatment planning system
Authors: Thewes Lena , Eckl Miriam , Schneider Frank 
Published: July 2023

AbstractIn the Monte Carlo‐based treatment planning system (TPS) Monaco, transmission probability filters (TPF) are utilized to describe the transmission through the multi leaf collimator (MLC). By having knowledge of the TPF parameters for various photon beam energies, adjusting the MLC transmission parameters becomes easier, enhancing the accuracy of the Monte Carlo algorithm in achieving a dose distribution that closely aligns with the irradiated dose at the Versa HD linear accelerator (linac). The objective of this study was to determine the TPF parameters for 6MV, 10MV, 6MV flattening filter free (FFF) and 10MV FFF for a Versa HD linac equipped with Agility MLC. The TPF parameters were adjusted using point dose measurements and vendor‐provided fields specifically designed to fine‐tune the MLC. After adjusting the TPF parameters, a gamma passing rate (GPR) analysis was conducted on 25 treatment plans to ensure that the Monte Carlo model, with the updated TPF parameters, accurately matched the actual linac delivery. The TPF values ranged from 0.0018 to 0.0032 for leaf transmission and 1.15 to 1.25 for Leaf Tip leakage across the different energies. The average GPR ranged from 97.8% for 10MV FFF to 98.5% for 6MV photon energies. Additionally, the TPF parameters for 6MV obtained in this study were consistent with previously published TPF values for 6MV photon energy. Hence, it was concluded that optimizing the TPF does not need to be performed for every individual Versa HD linac with Agility MLC. Instead, the published parameters can be applied to other Versa HD linacs to enhance clinical accuracy. In conclusion, this study determined the TPF parameters for 6MV and previously unpublished photon energies 10MV, 6MV FFF and 10MV FFF. These parameters can be easily transferred to other facilities, resulting in improved agreement between the dose distribution from the TPS and the linac.
Lowering Expectations: Glucocorticoid Tapering Among Veterans With Rheumatoid Arthritis Achieving Low Disease Activity on Stable Biologic Therapy
Authors: Wallace Beth I. , England Bryant R. , Baker Joshua F. , Rojas Jorge , Sauer Brian C. , Roul Punyasha , Kunkel Gary A. , Braaten Tawnie J. , Petro Alison , Mikuls Ted R. , Cannon Grant W. 
Published: July 2023

ObjectiveIn the Steroid EliMination In Rheumatoid Arthritis (SEMIRA) trial, 65% of patients with rheumatoid arthritis (RA) in low disease activity (LDA) on stable biologic therapy successfully tapered glucocorticoids. We aimed to evaluate real‐world rates of glucocorticoid tapering among similar patients in the Veterans Affairs Rheumatoid Arthritis registry.MethodsWithin a multicenter, prospective RA cohort, we used registry data and linked pharmacy claims from 2003 to 2021 to identify chronic prednisone users achieving LDA after initiating a new biologic or targeted synthetic disease‐modifying antirheumatic drug (b/tsDMARD). We defined the index date as first LDA occurring 60 to 180 days after b/tsDMARD initiation. The primary outcome of successful tapering, assessed at day 180 after LDA, required a 30‐day averaged prednisone dose both less than or equal to 5mg/day and at least 50% lower than at the index date. The secondary outcome was discontinuation, defined as a prednisone dose of 0 mg/day at days 180 through 210. We used univariate statistics to compare patient characteristics by fulfillment of the primary outcome.ResultsWe evaluated 100 b/tsDMARD courses among 95 patients. Fifty‐four courses resulted in successful tapering; 33 resulted in discontinuation. Positive rheumatoid factor, higher erythrocyte sedimentation rate, more background DMARDs, shorter time from b/tsDMARD initiation to LDA, and higher glucocorticoid dose 30 days before LDA were associated with greater likelihood of successful tapering.ConclusionIn a real‐world RA cohort of chronic glucocorticoid users in LDA, half successfully tapered and a third discontinued prednisone within 6 months of initiating a new b/tsDMARD. Claims‐based algorithms of glucocorticoid tapering and discontinuation may be useful to evaluate predictors of tapering in administrative data sets.