bluuebunny/crossref_metadata_2025_split huggingface dataset:
Can lymphocytes serve as a predictor of response to preoperative chemoradiation therapy for locally advanced rectal cancer?
Authors: Lutsyk Myroslav , Taha Tarek , Billan Salem 
Published: April 2023

IntroductionThe aim of this study is to identify factors that may predict the response of locally advanced rectal cancer tumors (LARC) to neoadjuvant chemoradiotherapy (CRT) and to evaluate the effect of circulating lymphocytes on pathological tumor response.MethodsThis retrospective study included neoadjuvant CRT-treated, LARC-diagnosed patients at the Rambam Health Care Campus in Haifa, Israel. CHAID analysis, t-test, χ2 test, and ROC curve analyses were performed to explore the association between pathological complete response (pCR) and several factors including patient demographics, tumor characteristics, type of treatment, and levels of circulating lymphocytes measured on a weekly basis.ResultsOut of 198 patients enrolled in the study, pCR was achieved in 50 patients (25%). ROC curve and CHAID analyses showed that absolute lymphopenia was significantly associated with lower pCR rates (p=0.046 and p=0.001, respectively). Other factors that were found to have a significant impact were radiation therapy type (p=0.033) and tumor distance from the anal verge (p= 0.041).ConclusionAn absolute decrease in the level of circulating lymphocytes during preoperative CRT to LARC is associated with poorer tumor response to treatment and thus may serve as a predictive biomarker for treatment resistance.
Can knowledge based treatment planning of VMAT for post-mastectomy locoregional radiotherapy involving internal mammary chain and supraclavicular fossa improve performance efficiency?
Authors: Phurailatpam Reena , Sah Muktar kumar , Wadasadawala Tabassum , Khan Asfiya , Palottukandy Jithin , Gayake Umesh , Jain Jeevanshu , Sarin Rajiv , Pathak Rima , Krishnamurthy Revathy , Joshi Kishore , Swamidas Jamema 
Published: April 2023

IntroductionTo validate and evaluate the performance of knowledge-based treatment planning for Volumetric Modulated Arc Radiotherapy for post-mastectomy loco-regional radiotherapy.Material and methodsTwo knowledge-based planning (KBP) models for different dose prescriptions were built using the Eclipse RapidPlanTM v 16.1 (Varian Medical Systems, Palo Alto, USA) utilising the plans of previously treated patients with left-sided breast cancer who had undergone irradiation of the left chest wall, internal mammary nodal (IMN) region and supra-clavicular fossa (SCF). Plans of 60 and 73 patients were used to generate the KBP models for the prescriptions of 40 Gy in 15 fractions and 26 Gy in 5 fractions, respectively. A blinded review of all the clinical plans (CLI) and KBPs was done by two experienced radiation oncology consultants. Statistical analysis of the two groups was also done using the standard two-tailed paired t-test or Wilcoxon signed rank test, and p&lt;0.05 was considered significant.ResultsA total of 20 metrics were compared. The KBPs were found to be either better (6/20) or comparable (10/20) to the CLIs for both the regimens. Dose to heart, contralateral breast,contralateral lung were either better or comparable in the KBP plans except of ipsilateral lung. Mean dose (Gy) for the ipsilateral lung are significantly (p˂0.001) higher in KBP though the values were acceptable clinically. Plans were of similar quality as per the result of the blinded review which was conducted by slice-by-slice evaluation of dose distribution for target coverage, overdose volume and dose to the OARs. However, it was also observed that treatment times in terms of monitoring units (MUs) and complexity indices are more in CLIs as compared with KBPs (p&lt;0.001).DiscussionKBP models for left-sided post-mastectomy loco-regional radiotherapy were developed and validated for clinical use. These models improved the efficiency of treatment delivery as well as work flow for VMAT planning involving both moderately hypo fractionated and ultra-hypo fractionated radiotherapy regimens.
High-resolution electric field and temperature distributions in positive streamers
Authors: Dijcks Siebe , Kusýn Lukáš , Janssen Jesper , Bílek Petr , Nijdam Sander , Hoder Tomáš 
Published: April 2023

In this work, we aim to take a detailed experimental picture of the positive streamer. We apply optical emission spectroscopy to the first negative system (FNS, B2Σu+→X2Σg+) of N2+ and the second positive system (SPS, C3Πu → B3Πg) of N2. Large, centimeter wide, and highly reproducible streamers are created in pure nitrogen and synthetic air, at pressures ranging from 33 to 266 mbar. Direct time resolved spectral imaging of the space charge layer resulted in spatiotemporal maps of the calculated reduced electric field strength (E/N) and rovibrational temperature in sub-nanosecond and sub-millimetre resolution. The E/N peaks at approximately 540 and 480  Td, directly in front of the space charge layer, for synthetic air and pure nitrogen respectively, as determined by using the intensity ratio method of FNS and SPS. A global model for pure nitrogen in PLASIMO uses the experimentally determined E/N distribution to draw a picture of the gas kinetics around the space charge layer passage. In addition, the results of the global model serve as a reference to interpret the rotational and vibrational temperatures obtained from experimental FNS and SPS emissions.
Genome-wide association study for grain zinc concentration in bread wheat (Triticum aestivum L.)
Authors: Ma Jianhui , Ye Miaomiao , Liu Qianqian , Yuan Meng , Zhang Daijing , Li Chunxi , Zeng Qingdong , Wu Jianhui , Han Dejun , Jiang Lina 
Published: April 2023

IntroductionZinc (Zn) deficiency causes serious diseases in people who rely on cereals as their main food source. However, the grain zinc concentration (GZnC) in wheat is low. Biofortification is a sustainable strategy for reducing human Zn deficiency.MethodsIn this study, we constructed a population of 382 wheat accessions and determined their GZnC in three field environments. Phenotype data was used for a genome-wide association study (GWAS) using a 660K single nucleotide polymorphism (SNP) array, and haplotype analysis identified an important candidate gene for GZnC.ResultsWe found that GZnC of the wheat accessions showed an increasing trend with their released years, indicating that the dominant allele of GZnC was not lost during the breeding process. Nine stable quantitative trait loci (QTLs) for GZnC were identified on chromosomes 3A, 4A, 5B, 6D, and 7A. And an important candidate gene for GZnC, namely, TraesCS6D01G234600, and GZnC between the haplotypes of this gene showed, significant difference (P ≤ 0.05) in three environments.DiscussionA novel QTL was first identified on chromosome 6D, this finding enriches our understanding of the genetic basis of GZnC in wheat. This study provides new insights into valuable markers and candidate genes for wheat biofortification to improve GZnC.
Does method matter? Assessing the validity and clinical utility of structured diagnostic interviews among a clinical sample of first-admitted patients with psychosis: A replication study
Authors: Kvig Erling Inge , Nilssen Steinar 
Published: April 2023

IntroductionIncreasingly, diagnostic assessments in clinical practice are made using structured diagnostic interviews or self-rating scales imported into clinical practice from research studies and big-scale surveys. Although structured diagnostic interviews have been shown to be highly reliable in research, the use of such method in clinical contexts are more questionable. In fact the validity and clinical utility of such methods in naturalistic contexts have rarely been evaluated. In this study we report on a replication study of Nordgaard et al (22) Assessing the diagnostic validity of a structured psychiatric interview in a first-admission hospital sample. World Psychiatry, 11 (3): 181–185.MethodsThe study sample comprises 55 first-admitted inpatients to a treatment facility specializing in the assessment and treatment of patients with psychotic disorders.ResultsWe found poor agreement between diagnoses generated by Structured Clinical Interview for DSM-IV and Best-estimate consensus diagnoses (κ value 0.21).DiscussionWe identified over-reliance on self-report, vulnerability to response set in dissimulating patients, and a strong diagnosis and comorbidity focus, as possible reasons for misdiagnosis with the SCID. We conclude that structured diagnostic interviews performed by mental health professionals without solid psychopathological knowledge and experience are not recommendable for clinical practice.
Exploring Black and South Asian women’s experiences of help-seeking and engagement in perinatal mental health services in the UK
Authors: Conneely Maev , Packer Katy C. , Bicknell Sarah , Janković Jelena , Sihre Harpreet Kaur , McCabe Rosemarie , Copello Alex , Bains Kiren , Priebe Stefan , Spruce Amy , Jovanović Nikolina 
Published: April 2023

Background and aimsIn the United Kingdom (UK), Black and South Asian women are less likely than White British women to access support from perinatal mental health services, despite experiencing similar, or higher, levels of distress. This inequality needs to be understood and remedied. The aim of this study was to answer two questions: how do Black and South Asian women experience (1) access to perinatal mental health services and (2) care received from perinatal mental health services?MethodSemi-structured interviews were conducted with Black and South Asian women (n = 37), including four women who were interviewed with an interpreter. Interviews were recorded and transcribed line-by-line. Data were analyzed using framework analysis, by an ethnically diverse multidisciplinary team of clinicians, researchers and people with lived experience of perinatal mental illness.ResultsParticipants described a complex interplay of factors that impacted on seeking, and receiving help, and benefiting from services. Four themes emerged that captured the highly varied experiences of individuals: (1) Self-identity, social expectations and different attributions of distress deter help-seeking; (2) Hidden and disorganized services impede getting support; (3) The role of curiosity, kindness and flexibility in making women feel heard, accepted and supported by clinicians; (4) A shared cultural background may support or hinder trust and rapport.ConclusionWomen described a wide range of experiences and a complex interplay of factors impacting access to, and experience of, services. Women described services as giving them strength and also leaving them disappointed and confused about where to get help. The main barriers to access were attributions related to mental distress, stigma, mistrust and lack of visibility of services, and organizational gaps in the referral process. These findings describe that many women feel heard, and supported by services, reporting that services provide a high quality of care that was inclusive of diverse experiences and understandings of mental health problems. Transparency around what PMHS are, and what support is available would improve the accessibility of PMHS.
The contribution of transdiagnostic vulnerability factors in patients with chronic insomnia
Authors: Habibi Asgarabad Mojtaba , Doos Ali Vand Hoda , Salehi Yegaei Pardis , Hooman Farzaneh , Ahmadi Reza , Baglioni Chiara , Moradi Shahram 
Published: April 2023

IntroductionVarious transdiagnostic factors have been associated with insomnia severity. The current study aimed to predict insomnia severity based on a group of transdiagnostic factors including neuroticism, emotion regulation, perfectionism, psychological inflexibility, anxiety sensitivity, and repetitive negative thinking after controlling for depression/anxiety symptoms and demographic characteristics.MethodsTwo hundred patients with chronic insomnia disorder were recruited from a sleep disorder clinic. Participants completed the Insomnia Severity Index (ISI), Clinical Perfectionism Questionnaire (CPQ), Acceptance and Action Questionnaire-II (AAQ-II), Anxiety Sensitivity Index-3 (ASI-3), Repetitive Thinking Questionnaire (RTQ-10), Big Five Inventory (BFI-10), Emotion Regulation Questionnaire (ERQ), and Depression Anxiety Stress Scale (DASS-21).ResultsAfter controlling for the confounding variables (depression/anxiety symptoms and demographic characteristics), hierarchical multiple linear regression suggested the significant association of neuroticism (BFI), cognitive reappraisal (ERQ), personal standards (CPQ), evaluative concerns (CPQ), physical concerns (ASI), cognitive concerns (ASI), and repetitive negative thinking (RTQ) with insomnia severity.DiscussionThe findings support the role of transdiagnostic factors, especially physical concerns, repetitive negative thinking, and neuroticism in chronic insomnia. Future research using longitudinal designs is required to verify the causal status of transdiagnostic variables.
Small bowel neuroendocrine tumors: An analysis of clinical presentation, diagnostic workup and surgical approach—A single center retrospective study
Authors: Kroepfl Veronika , Bellotti Ruben , Gasser Elisabeth , Esswein Katharina , Esser Hannah , Kafka-Ritsch Reinhold , Öfner Dietmar , Perathoner Alexander 
Published: April 2023

BackgroundNeurocrine neoplasms (NEN) of the small bowel (SBNEN) are a rare entity and mostly asymptomatic. The aim of this study was to explore trends in the clinical presentation, diagnostic workup, surgical approach and oncological outcome in patients with SBNEN at our surgical department.Materials and methodsAll patients who underwent surgical resection for SBNEN from 2004 to 2020 at our department were enrolled in this single center retrospective study.ResultsA total of 32 patients were included in this study. In most cases, the diagnosis was based on incidental findings during endoscopy or radiographic imaging (n = 23; 72%). Twenty cases had a G1 tumor and 12 cases a G2 tumor. The 1-, 3- and 5-year overall survival (OS) were 96%, 86% and 81%, respectively. Patients with a tumor more than 30 mm had a significantly lower OS (p = 0.01). For G1 tumors, the estimated disease-free survival (DFS) was 109 months. Again, the DFS was significantly lower when the tumor had more than 30 mm in diameter (p = 0.013).ConclusionDue to the mostly asymptomatic presentation, the diagnostic workup can be difficult. An aggressive approach and a strict follow-up seem to be important for the oncological outcome.
Population Structure and Genetic Diversity in the Natural Distribution of Neolamarckia cadamba in China
Authors: Lv Yan-Wen , He Zi-Han , Xiao Yu , Ouyang Kun-Xi , Wang Xi , Hu Xin-Sheng 
Published: April 2023

Neolamarckia cadamba (Roxb.) Bosser is a fast-growing deciduous tree species and belongs to the Neolamarckia genus of the Rubiaceae family. This species has great economic and medical values in addition to being an important timber species for multiple industrial purposes. However, few studies have examined the genetic diversity and population structure in the natural distribution of this species in China. Here, we applied both the haploid nrDNA ITS (619 bp for aligned sequences) and mtDNA (2 polymorphic loci) markers to investigate 10 natural populations (239 individuals in total) that covered most of the distribution of the species in China. The results showed that the nucleotide diversity was π = 0.1185 ± 0.0242 for the nrDNA ITS markers and π = 0.00038 ± 0.00052 for the mtDNA markers. The haplotype diversity for the mtDNA markers was h = 0.1952 ± 0.2532. The population genetic differentiation was small (Fstn = 0.0294) for the nrDNA ITS markers but large (Fstm = 0.6765) for the mtDNA markers. There were no significant effects of isolation by distance (IBD), by elevation, and by two climatic factors (annual average precipitation and tem perature). A geographic structure among populations (Nst<Gst) was absent. Phylogenetic analysis showed a highly genetic mixture among individuals of the ten populations. Pollen flow was substantially greater than seed flow (mp/ms ≫ 1.0) and played a dominant role in shaping population genetic structure. The nrDNA ITS sequences were neutral and all local populations did not undergo demographic expansion. The overall results provide fundamental information for the genetic conservation and breeding of this miraculous tree.
Une page majeure de la zoologie lyonnaise : René Koehler (1860-1931) et la campagne océanographique du Caudan (1895)
Authors: d'Hondt Jean-Loup , Carpine-Lancre Jacqueline 
Published: April 2023

Pour le cent vingtième anniversaire de la campagne océanographique du Caudan dans le golfe de Gascogne, organisée en 1895 par le professeur René Koehler pour enrichir les collections zoologiques de la faculté des Sciences de Lyon, rappel des données
essentielles concernant cette mission : noms et biographies des scientifiques embarqués et des déterminateurs du matériel ; contexte administratif ; publication des résultats.
Enchophora sanguiflua n. sp., une nouvelle espèce néotropicale de Fulgoridae (Hemiptera : Fulgoromorpha)
Authors: Audibert Cédric , Porion Thierry 
Published: April 2023

Une nouvelle espèce de Fulgoridae est séparée d’Enchophora stillifera.
Si les populations de Panamá et du sud du Costa Rica sont bien à rapporter à cette espèce, celles du Nicaragua, du Honduras et du Guatemala appartiennent à une autre espèce ici décrite. La localité type d’E. stillifera donnée dans la description (Mexico) ne correspond pas à la localité du spécimen-type présent dans les collections du Rijksmuseum à Stockholm. Il s’agit vraisemblablement d’un lapsus calami pour la localité ‘ Chiriqui’ dont la consonance rappelle plusieurs toponymes mexicains.
Implementation of the official document management policy within the north sulawesi provincial government
Authors: Owu Alfrets R. , Pratiknjo Maria H. , Tampi Jhony R. E. 
Published: April 2023

This study aims to analyze the implementation of official document arrangement (TND) policies within the North Sulawesi provincial government. This study uses a qualitative descriptive method based on Grindle's theory with indicators consisting of policy content and policy environment. The research informants were taken using a purposive sampling technique, totaling 8 informants. Data analysis uses data reduction, data presentation and conclusion drawing. The results showed that the management of official document within the North Sulawesi provincial government was based on Governor Regulation Number 34 of 2010 which was based on the Regulation of the Minister of Home Affairs Number 54 of 2009. The management of the official document arrangement is still hampered by a number of issues, such as each Regional Apparatus Work Unit (SKPD) use of a non-uniform format and the usage of logos and stamps that do not adhere to established guidelines. Instead, the format is governed by the preferences of the specific SKPD leaders. The North Sulawesi government has decided to employ an electronic-based government system (PBSE); however, they still manage official documents manually. The use of an electronic/digital system can reduce the need for paper and ink, speed up the correspondence system, and make the process of storing archives easier because using a manual technique runs the risk of damaging paper records due to ageing.
Presentación. Ética y formación universitaria
Authors: Martínez Santiago Roberto 
Published: April 2023

En el amplio marco que nos presta el título «Ética y formación universitaria», la Revista trata, en la parte monográfica de este número, una cantidad importante de enfoques sobre una cuestión que va ganando un espacio cada vez más significativo en los debates académicos sobre el moderno papel de las instituciones universitarias en sociedades democráticas y plurales.
De esta forma pretendemos responder a las expectativas de nuestros lectores, que, a través de numerosas y diversas aportaciones, vienen reflejando el interés que por estas cuestiones tiene la comunidad académica en Iberoamérica.
Muestra de ese interés son los más de dieciocho meses en los que se viene debatiendo en la versión digital de la Revista , y a propuesta de la lectora Ana Teresa Molina Álvarez, si ¿se pueden formar valores en la universidad?
Intentamos aportar desde este monográfico, y por medio de las colaboraciones de reconocidos expertos en ética, educación moral y formación docente, nuevos elementos y perspectivas que enriquezcan el tratamiento del tema principal –la relación entre ética y formación universitaria–, pero también el de las cuestiones derivadas del mismo, como son las que vinculan a la ética con el ejercicio de las profesiones, con la función no-profesional de los egresados universitarios y con las consecuencias –públicas y privadas– del accionar de estos titulados y de las instituciones donde se formaron.
Un juego instructivo en la computadora para el aprendizaje de la adición y la sustracción en las primeras edades
Authors: Cruz López Yordanis 
Published: April 2023

La enseñanza de las Matemáticas siempre ha sido un reto para las sociedades, la experiencia cotidiana, y algunas técnicas de investigación aplicadas en las escuelas de nuestra comunidad, demuestran que a los alumnos les resulta difícil el aprendizaje de las operaciones matemáticas básicas en los primeros grados, lo cual repercute negativamente en el aprendizaje de contenidos posteriores con más complejidad.
Sin embargo, se evidencia que en reiteradas ocasiones los métodos empleados por los maestros son meramente tradicionales y que distan mucho de la realidad actual.
El Aprendizaje Cooperativo como estrategia de Enseñanza-Aprendizaje en Psicopedagogía (UC): repercusiones y valoraciones de los estudiantes
Authors: González Fernández Natalia , García Ruiz María Rosa 
Published: April 2023

La reforma educativa actual enfatiza los procedimientos, valores y actitudes que constituyen el currículo y la intervención educativa. Según éste, lenguaje e impulso, el trabajo en grupo, la formación de equipos de aprendizaje, el desarrollo de actitudes de cooperación, etc., constituyen una variable importante de formación básica en la Enseñanza Superior, de cara a una eficaz integración de los egresados en el ámbito laboral.
En este proceso de convergencia la actividad docente adquiere nuevos enfoques (tutorización y atención más personalizada del alumno, seguimiento y evaluación de las actividades no presenciales, coordinación entre docencia presencial y no presencial...), lo que supone implicaciones directas en la metodología docente (Zabalza, 2000; Mayor, 2003). Es por esto por lo que consideramos fundamental el conocimiento y utilización de otras técnicas o estratégicas metodológicas que aseguren el proceso de enseñanza-aprendizaje, en el que el alumno ha de ser el eje fundamental, en torno al cuál gire el diseño de los currículos de cada plan de estudios.