bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparative Study of Biochars from the Retort Co-Carbonization of Corn Cob and Polyethylene Wastes
Authors: Amoloye Mubarak , Abdulkareem Sulyman , Adeniyi Adewale 
Published: April 2023

Biochar is a pyrogenic, carbon-rich by-product of the products of biomass valorization. Its applications include source of heat, carbon sequestration, soil improvement, adsorbent, chelating agent and niche for micro-organism growth. The study focused on the retort carbonization of corn cob and co-carbonization of corn cob and polyethylene waste for comparative studies using a top-lit updraft conversion reactor with retort heating. The properties of the biochars were analyzed using Scanning Electron Microscopy - Energy Dispersive X-ray (SEM-EDX) and Branueur-Emmet-Teller (BET). Results revealed the ordinary biochar had a homogeneous surface with repeating patterns forming a honeycomb-like structure with a 62% carbon composition while the hybrid biochar had a heterogeneous surface with a rough pattern and ridges with an 80% carbon composition. The heterogeneity and increase in carbon composition observed in the hybrid biochar were attributed to the presence of the polyethylene waste. Biochars with high carbon contents can find their applications in areas of carbon sequestrations. The biochar and hybrid biochar were found to be porous with specific surface areas of 392.5 m2/g and 889.9 m2/g respectively. The high specific surface area of the hybrid biochar produced highlights its potential as an adsorbent. Biochar with high levels of porosity is also useful in soil enhancement. The co-carbonization of corncob and polyethylene waste has been established to be a means of conversion of both agricultural and plastic wastes into biochar with various potential applications.
Data Supplement from Phase I Expansion and Pharmacodynamic Study of the Oral MEK Inhibitor RO4987655 (CH4987655) in Selected Patients with Advanced Cancer with <i>RAS–RAF</i> Mutations
Authors: Zimmer Lisa , Barlesi Fabrice , Martinez-Garcia Maria , Dieras Veronique , Schellens Jan H.M. , Spano Jean-Philippe , Middleton Mark R. , Calvo Emiliano , Paz-Ares Luiz , Larkin James , Pacey Simon , Venturi Miro , Kraeber-Bodéré Françoise , Tessier Jean J.L. , Eberhardt Wilfried Ernst Erich , Paques Michel , Guarin Ernesto , Meresse Valerie , Soria Jean-Charles 
Published: April 2023

<p>Supplementary Figure 2. Case study: 64-year old female with <i>BRAF</i> V600-mutant melanoma (A)	Immunhistochemistry for Ki67 expression showing a reduction between baseline and cycle1/day15 in lymph node biopsies (B)	Immunhistochemistry for pERK expression showing a reduction between baseline and cycle5/day1 in lymph node biopsies (C)	FDG-PET uptake at baseline (D)	FDG-PET metabolic partial response at day 15 of cycle 1 (E)	CT scan images at baseline (F)	CT scan images at day 1 of cycle 5 show a 80% reduction in target lesion size, indicating partial response</p>
Supplementary Table 1 from High <i>BCR–ABL/GUS<sup>IS</sup></i> Levels at Diagnosis of Chronic Phase CML Are Associated with Unfavorable Responses to Standard-Dose Imatinib
Authors: Vigneri Paolo , Stagno Fabio , Stella Stefania , Cupri Alessandra , Forte Stefano , Massimino Michele , Antolino Agostino , Siragusa Sergio , Mannina Donato , Impera Stefana Stella , Musolino Caterina , Malato Alessandra , Mineo Giuseppe , Tomaselli Carmela , Murgano Pamela , Musso Maurizio , Morabito Fortunato , Molica Stefano , Martino Bruno , Manzella Livia , Müller Martin C. , Hochhaus Andreas , Raimondo Francesco Di 
Published: April 2023

<p>Supplementary Table 1.	Patient Characteristics (N = 272)</p>
Data from A Five-Gene and Corresponding Protein Signature for Stage-I Lung Adenocarcinoma Prognosis
Authors: Kadara Humam , Behrens Carmen , Yuan Ping , Solis Luisa , Liu Diane , Gu Xuemin , Minna John D. , Lee J. Jack , Kim Edward , Hong Waun-Ki , Wistuba Ignacio I. , Lotan Reuben 
Published: April 2023

<div>Abstract<p><b>Purpose:</b> Identification of effective markers for outcome is expected to improve the clinical management of non–small cell lung cancer (NSCLC). Here, we assessed in NSCLC the prognostic efficacy of genes, which we had previously found to be differentially expressed in an <i>in vitro</i> model of human lung carcinogenesis.</p><p><b>Experimental Design:</b> Prediction algorithms and risk-score models were applied to the expression of the genes in publicly available NSCLC expression data sets. The prognostic capacity of the immunohistochemical expression of proteins encoded by these genes was also tested using formalin-fixed paraffin-embedded (FFPE) tissue specimens from 156 lung adenocarcinomas and 79 squamous cell carcinomas (SCCs).</p><p><b>Results:</b> The survival of all-stages (<i>P</i> < 0.001, HR = 2.0) or stage-I (<i>P</i> < 0.001, HR = 2.84) adenocarcinoma patients that expressed the five-gene <i>in vitro</i> lung carcinogenesis model (FILM) signature was significantly poorer than that of patients who did not. No survival differences were observed between SCCs predicted to express or lack FILM signature. Moreover, all stages (<i>P</i> < 0.001, HR = 1.95) or stage-I (<i>P</i> = 0.001, HR = 2.6) adenocarcinoma patients predicted to be at high risk by FILM transcript exhibited significantly worse survival than patients at low risk. Furthermore, the corresponding protein signature was associated with poor survival (all stages, <i>P</i> < 0.001, HR = 3.6; stage-I, <i>P</i> < 0.001, HR = 3.5; stage-IB, <i>P</i> < 0.001, HR = 4.6) and mortality risk (all stages, <i>P</i> = 0.001, HR = 4.0; stage-I, <i>P</i> = 0.01, HR = 3.4; stage-IB, <i>P</i> < 0.001, HR = 7.2) in lung adenocarcinoma patients.</p><p><b>Conclusions:</b> Our findings highlight a gene and corresponding protein signature with effective capacity for identification of stage-I lung adenocarcinoma patients with poor prognosis that are likely to benefit from adjuvant therapy. <i>Clin Cancer Res; 17(6); 1490–501. ©2010 AACR.</i></p></div>
Data from Clonal Evolution, Genomic Drivers, and Effects of Therapy in Chronic Lymphocytic Leukemia
Authors: Ouillette Peter , Saiya-Cork Kamlai , Seymour Erlene , Li Cheng , Shedden Kerby , Malek Sami N. 
Published: April 2023

<div>Abstract<p><b>Purpose:</b> The identification of gene mutations and structural genomic aberrations that are critically involved in chronic lymphocytic leukemia (CLL) pathogenesis is still evolving. One may postulate that genomic driver lesions with effects on CLL cell proliferation, apoptosis thresholds, or chemotherapy resistance should increase in frequency over time when measured sequentially in a large CLL cohort.</p><p><b>Experimental Design:</b> We sequentially sampled a large well-characterized CLL cohort at a mean of 4 years between samplings and measured acquired copy number aberrations (aCNA) and LOH using single-nucleotide polymorphism (SNP) 6.0 array profiling and the mutational state of <i>TP53</i>, <i>NOTCH1</i>,<i> </i>and <i>SF3B1</i> using Sanger sequencing. The paired analysis included 156 patients, of whom 114 remained untreated and 42 received intercurrent therapies, predominantly potent chemoimmunotherapy, during the sampling interval.</p><p><b>Results:</b> We identify a strong effect of intercurrent therapies on the frequency of acquisition of aCNAs in CLL. Importantly, the spectrum of acquired genomic changes was largely similar in patients who did or did not receive intercurrent therapies; therefore, various genomic changes that become part of the dominant clones are often already present in CLL cell populations before therapy. Furthermore, we provide evidence that therapy of CLL with preexisting <i>TP53</i> mutations results in outgrowth of genomically very complex clones, which dominate at relapse.</p><p><b>Conclusions:</b> Using complementary technologies directed at the detection of genomic events that are present in substantial proportions of the clinically relevant CLL disease bulk, we capture aspects of genomic evolution in CLL over time, including increases in the frequency of genomic complexity, specific recurrent aCNAs, and <i>TP53</i> mutations. <i>Clin Cancer Res; 19(11); 2893–904. ©2013 AACR</i>.</p></div>
Numerical investigation on combustion flow characteristics of a micro gas turbine swirl combustor with different protruded bluff body structures
Authors: Liu Hong , Zeng Zhuoxiong , Guo Kaifang 
Published: April 2023

A micro gas turbine swirl combustor with protruded bluff body is proposed. Compared with no bluff body, the protruded bluff body can significantly improve the combustion performance. When the bluff body height is 40 mm and the length is 30 mm, the average outlet NO emission is reduced by 14.43%, the pressure loss is decreased by 5.96%, and the outlet temperature distribution factor (OTDF) is dropped by 31.93%. The influence of different bluff body lengths (15–30 mm) and heights (10–50 mm) on the combustion flow are numerically analyzed further. The results show that the change of bluff body structure will affect the performance of combustor. In the range of 15–25 mm, with the increase of the bluff body length, the scope of central recirculation zone becomes narrower, velocity near the inlet and pressure loss decrease, the OTDF and field synergy angle β both become larger. When the bluff body length grows from 15 mm to 30 mm, the average outlet NO emission increases by 36.74%. The range of the central recirculation zone is gradually widen, and the average reaction rate grows up with the increase of bluff body height. The synergistic effect becomes better, and the heat transfer capacity is enhanced. When the bluff body height grows from 30 mm to 50 mm, the average outlet NO emission reduces from 35.84 ppm to 25.65 ppm.
Efficacy and Safety of Fluvoxamine as Outpatient Treatment for Patients With Covid-19: A Systematic Review and Meta-analysis of Clinical Trials
Authors: Vatvani Akhil Deepak , Kurniawan Andree , Hariyanto Timotius Ivan 
Published: April 2023

Background: Fluvoxamine may be beneficial for the management of coronavirus disease 2019 (Covid-19) because of its effect on the sigma-1 receptor. Available evidence from randomized clinical trials (RCTs) has shown conflicting results. Objective: This study sought to analyze the efficacy and safety of fluvoxamine as an outpatient treatment for Covid-19. Methods: Using specific keywords, we comprehensively go through the potential articles on PubMed, Scopus, Europe PMC, and ClinicalTrials.gov sources until February 1, 2023. We collected all published clinical trials on fluvoxamine and Covid-19. We were using Review Manager 5.4 to conduct statistical analysis. Results: We include a total of 6 trials. Our pooled analysis revealed that fluvoxamine did not offer any significant benefit when compared with placebo in reducing the risk of clinical deterioration (risk ratio [RR] = 0.83; 95% CI: 0.65-1.06, P = 0.14, I2 = 29%), and hospitalization (RR = 0.80; 95% CI: 0.62-1.04, P = 0.09, I2 = 0%) of Covid-19 outpatients. The serious adverse events did not differ significantly between the 2 groups. Conclusions and Relevance: This study indicates that although safe, fluvoxamine was not effective for outpatient treatment of Covid-19. Until more evidence can be obtained from larger RCTs, our study did not encourage the use of fluvoxamine as routine management for patients with Covid-19.
Melatonin attenuated chronic visceral pain by reducing Nav1.8 expression and nociceptive neuronal sensitization
Authors: Lv Meng-Dan , Wei Ying-Xue , Chen Jian-Peng , Cao Ming-Yao , Wang Qian-Liang , Hu Shufen 
Published: April 2023

Background Irritable bowel syndrome (IBS) is a common functional gastrointestinal disorder, and its specific pathogenesis is still unclear. We have previously reported that TTX-resistant (TTX-R) sodium channels in colon-specific dorsal root ganglion (DRG) neurons were sensitized in a rat model of visceral hypersensitivity induced by neonatal colonic inflammation (NCI). However, the detailed molecular mechanism for activation of sodium channels remains unknown. This study was designed to examine roles for melatonin (MT) in sensitization of sodium channels in NCI rats. Methods Colorectal distention (CRD) in adult male rats as a measure of visceral hypersensitivity. Colon-specific dorsal root ganglion (DRG) neurons were labeled with DiI and acutely dissociated for measuring excitability and sodium channel current under whole-cell patch clamp configurations. Western blot and Immunofluorescence were employed to detect changes in expression of Nav1.8 and MT2. Results The results showed that rats exhibited visceral hypersensitivity after NCI treatment. Intrathecal application of melatonin significantly increased the threshold of CRD in NCI rats with a dose-dependent manner, but has no role in the control group. Whole-cell patch clamp recording showed that melatonin remarkably decreased the excitability and the density of TTX-R sodium channel in DRG neurons from NCI rats. The expression of MT2 receptor at the protein level was markedly lower in NCI rats. 8MP, an agonist of MT2 receptor, enhanced the distention threshold in NCI rats. Application of 8MP reversed the enhanced hypersensitivity of DRG neurons from NCI rats. 8MP also reduced TTX-R sodium current density and modulated dynamics of TTX-R sodium current activation. Conclusions These data suggest that sensitization of sodium channels of colon DRG neurons in NCI rats is most likely mediated by MT2 receptor, thus identifying a potential target for treatment for chronic visceral pain in patients with IBS.
Encouraging planting in urban front gardens: a focus group study
Authors: Frost RH , Murtagh N 
Published: April 2023

Aims: Encouraging planting in front gardens offers mental and physical health benefits, as well as positive local environmental impacts such as reducing flood risk and improving air quality. However, urban front garden greenery has reduced in recent years. We aimed to explore adults’ views regarding planting greenery in front gardens, barriers and facilitators, and their understanding of health and environmental impacts, to identify appropriate intervention mechanisms for behaviour change. Methods: We carried out five online focus groups with 20 participants aged 20–64 in England, purposively sampled for variation according to age, gender, home ownership, income, ethnicity and residing in an urban or suburban area. We audio recorded each focus group, transcribed it verbatim and analysed transcripts using thematic analysis. Results: Front gardening was a relaxing activity that provided benefits including increased wellbeing, fresh air and vitamin D. Planting in front gardens depended heavily on available time and space, garden orientation, local security and the weather. Front gardens could be a place for social interaction. Participants tended to prioritise neatness and tidiness over greenery. Lack of knowledge and low self-efficacy were key barriers. There was little awareness of the environmental benefits of front garden greenery; however, reducing flood risk and encouraging biodiversity were viewed positively. Conclusion: Initiatives to encourage front garden planting should focus on plants that require little knowledge to acquire and care for, are suitable to the local environmental conditions and with a visual impact of neatness and bright colour. Campaigns should draw attention to local flood risk reduction and increasing biodiversity, in addition to personal health benefits.
Clinical utility of pretreatment serum squamous cell carcinoma antigen for prognostication and decision-making in patients with early-stage cervical cancer
Authors: Huang Xiao-Dan , Huo Lan-Qing , Luo Ying-Shan , Chen Kai , Li Jun-Yun , Shi Liu , Huang Lin , Cao Xin-Ping , Ou-Yang Yi , Chen Fo-Ping 
Published: April 2023

Background: To investigate the prognostic role of pretreatment squamous cell carcinoma antigen (SCCA) in early-stage cervical cancer (CC). Methods: We enrolled 487 cases of pathology-proven early-stage [International Federation of Gynecology and Obstetrics (FIGO) I/II] squamous or adenosquamous CC that were treated from 2012 to 2015. Restricted cubic splines (RCS) with a full Cox regression model were used to evaluate the association between SCCA levels and survival outcomes. Recursive partitioning analysis (RPA) was used to construct a risk stratification model for overall survival (OS). The performance of the RPA-based model was assessed using a receiver operating characteristic (ROC) curve. Results: RCS analysis revealed an association between SCCA and OS and disease-free survival (DFS); SCCA ⩾2.5 ng/mL was robust for risk discrimination in our cohort. SCCA had an interaction effect with FIGO classification: Patients with FIGO I and SCCA ⩾2.5 ng/mL overlapped with those with FIGO II and SCCA < 2.5 ng/mL for OS [hazard ratio, 1.04 (95% confidence interval (CI): 0.49–2.24), p = 0.903] and DFS [1.05 (0.56–1.98), p = 0.876]. RPA modeling incorporating SCCA (<2.5 ng/mL and ⩾2.5 ng/mL) and FIGO classification divided CC into three prognostic groups: RPA I, FIGO stage I, and SCCA < 2.5 ng/mL; RPA II, FIGO stage I, and SCCA ⩾ 2.5 ng/mL, or FIGO stage II and SCCA < 2.5 ng/mL; and RPA III, FIGO stage II, and SCCA ⩾ 2.5 ng/mL; with 5-year OS of 94.0%, 85.1%, and 73.5%, respectively ( p < 0.001). ROC analysis confirmed that the RPA model outperformed the FIGO 2018 stage with significantly improved accuracy for survival prediction [area under the curve: RPA versus FIGO, 0.663 (95% CI: 0.619–0.705] versus 0.621 (0.576–0.664), p = 0.045]. Importantly, the RPA groupings were associated with the efficacy of treatment regimens. Surgery followed by adjuvant treatment had a higher OS ( p < 0.01) and DFS ( p = 0.024) than other treatments for RPA III, whereas outcomes were comparable among treatment regimens for RPA I–II. Conclusion: Herein, the role of SCCA for prognostication was confirmed, and a robust clinicomolecular risk stratification system that outperforms conventional FIGO classification in early-stage squamous and adenosquamous CC was presented. The model correlated with the efficacy of different treatment regimes.
Spontaneous lumbar intraspinal subdural abscess: a case report
Authors: MacCormac Oscar James , Berjaoui Nabih , Mizzi Sean , Wang Difei , Patel Sabina , Al Banna Qusai , Bleil Cristina 
Published: April 2023

Abstract
Background
Subdural spinous abscess is a rare pathology that carries significant morbidity if not diagnosed and treated early; of the cases reported in the literature, very few are genuinely spontaneous in nature.

Case presentation
Here we demonstrate the case of an otherwise entirely fit and well 56-year-old White, British female presenting with low back pain, bilateral sciatica and sensate urinary retention; lumbar subdural spinous abscess was diagnosed on urgent magnetic resonance imaging and the patient was successfully managed with surgical evacuation and prolonged antibiotic therapy. The patient made a full neurological recovery and was followed-up in the outpatient setting 12 weeks following her initial surgery; she was pain free with normal inflammatory markers and a normal neurological examination. There have been no further consultations and a telephone call at 20 weeks confirmed that she remains well.

Conclusions
This is the second case reported in the literature of a genuinely spontaneous subdural spinous abscess, which was successfully managed with surgical evacuation following prompt diagnosis. This highlights the need to ensure infective pathologies are kept at the back of one’s mind even in the most unlikely circumstances, and that excellent outcomes can be achieved with early surgical intervention.
Witold Świętochowski – sylwetka agenta gdańskiego gestapo
Authors: Gąsiorowski Andrzej 
Published: April 2023

Artykuł uzupełnia wiedzę o najbardziej znanym agencie gdańskiego gestapo Witoldzie Świętochowskim. Ten przedwojenny współpracownik polskiego wywiadu wojskowego, pochodzący z patriotycznej rodziny zamieszkałej w Sopocie, jest postacią wielokrotnie już opisywaną, lecz do tej pory nikt nie dotarł do jego fotografii. Autor podczas penetrowania zasobów cyfrowych archiwum Międzynarodowego Centrum Badań Prześladowań Nazistowskich w Arolsen dotarł do ankiety personalnej z fotografią. Wpisy uczynione przez Świętochowskiego pozwalają spojrzeć na jego agenturalną działalność od jego strony, przynoszą też szereg ciekawych informacji i pozwalają zadać nowe pytania badawcze dotyczące jego powojennych losów.
Studies of the silkworm enzyme activity and their correlations with economic variables
Authors: Yeremenko Sergiy , Wani Mohd Younus , Ganie Nisar Ahmad , Mir Mushtaq Rasool , Mir Shakeel Ahmad , Yaqoob Munazah , Murtaza Imtiyaz , Wani Tanveer Ahmad , Baqual Mohd Farooq , Sukennikov Oleksii 
Published: April 2023

The experiment was conducted to analyse the larval performance and economic traits of bivoltine silkworm breeds of silkworm (SK-1, SK-6, SK-22, SK-28, SK-33, CSR4, CSR2, NB4D2, DUN6 and APS4) during spring season. The haemolymph total protein, succinate and gultamate dehydrogenase activities were estimated and their correlation with economic traits were also worked out. The results of the study confirmed that among ten bivoltine silkworm breeds, highest haemolymph SDH activity of 3.47 µmoles/ml/mgprotein/min was recorded in the silkworm breed SK1 and least SDH activity of 1.58 µmoles/ml/mg protein/min was recorded in the breed APS4. The highest peak of succinate dehydrogenase activity of 2.65 µmoles/ml/mg protein/min was observed on 7th day of the 5th instar and lowest peak of succinate dehydrogenase activity of 2.39 µmoles/ml/mg protein/min was observed on 4th day of the 5th instar. GDH activity of 0.46 µmoles/ml/mg protein/min was recorded highest in the silkworm breed SK1 and lowest of 0.15 µmoles/ml/mg protein/min was recorded in silkworm breed APS4. The highest peak of haemolymph GDH of 0.36 µmoles/ml/mg protein/min was recorded on 7th day of 5th instar and lowest peak of 0.26 µmoles/ml/mg protein/min was recorded on 4th day of 5th instar. The correlational studies revealed that haemolymph total protein, SDH and GDH were found to be positively corelated with yield by weight and number (cocoon), weight of mature larvae, shell weight ,cocoon weight, shell ratio percent, silk productivity, rate of pupation, fecundity, raw silk percentage and length of filament. Thus, the study revealed that silkworm breeds like SK1, SK6, SK22 and SK28 as productive breeds and hence may be used for future breeding programmes for evolution of new robust silkworm breeds
Cel Eucharystii w ujęciu teologii liturgicznej
Authors: Migut Bogusław 
Published: April 2023

Różnorodności wymiarów Eucharystii zasadza się różnorodność pojmowania celu Eucharystii. Głównym problemem badawczym tego opracowania jest udzielenie odpowiedzi na pytanie o cel ustanowienia przez Chrystusa i sprawowania przez Chrystusa i przez Kościół Eucharystii. Polem badawczym jest tu teologia liturgiczna, która łączy w sobie zbawcze misterium Chrystusa, jego celebrację i życie chrześcijańskie. Łączność ta jest pierwszym wspólnym mianownikiem, dla różnych ujęć teologii liturgicznej, wskazującym na celowość Eucharystii. Taki cel Eucharystii najmocniej akcentuje szkoła rzymska teologii liturgicznej. U podstaw różnych szkół teologii liturgicznej znajdują się dwaj teologowie chrześcijańskiego Wschodu, Alexander Schmemann i Jean Corbon, dla których głównym celem Eucharystii jest celebracja nieustannego objawiania się i udzielania się Boga, co sprawia, że Eucharystia jest nieustannym zanurzaniem codzienności w eschatologii. Celem Eucharystii w ujęciu amerykańskiej teologii liturgicznej jest nieustanne formowanie jej uczestników jako kościelnej wspólnoty kapłanów stworzenia, zjednoczonych z Chrystusem i działających jego mocą. Wszyscy ci teologowie pomimo różnic akcentują szczególny sposób budowania przez Eucharystię wspólnoty Kościoła oraz kult składany Ojcu przez Chrystusa przyłączającego do siebie Kościół i włączającego w swoją ofiarę duchowe ofiary wiernych.