bluuebunny/crossref_metadata_2025_split huggingface dataset:
Octadecanoids as emerging lipid mediators in cnidarian-dinoflagellate symbiosis
Authors: wheelock craig , Botana Marina , Lewis Robert , Quaranta Alessandro , Salamin Olivier , Revol-Cavalier Johanna , Oakley Clint , Feussner Ivo , Hamberg Mats , Grossman Arthur , Suggett David , Weis Virginia , Davy Simon 
Published: January 2025

Abstract

Oxylipin signaling has been suggested as a potential mechanism for the inter-partner recognition and homeostasis regulation of cnidarian-dinoflagellate symbiosis, which maintains the ecological viability of coral reefs. Here we assessed the effects of symbiosis and symbiont identity on a model cnidarian, the sea anemone Exaiptasia diaphana, using mass spectrometry to quantify octadecanoid oxylipins (i.e., 18-carbon-derived oxygenated fatty acids). A total of 84 octadecanoids were reported, and distinct stereospecificity was observed for the synthesis of R- and S-enantiomers for symbiont-free anemones and free-living cultured dinoflagellate symbionts, respectively. Symbiont-derived 13(S)-hydroxy-octadecatetraenoic acid (13(S)-HOTE) linked to a 13(S)-lipoxygenase was translocated to the host anemone with a 32-fold increase, suggesting it as a biomarker of symbiosis and as a potential agonist of host receptors that regulate inflammatory transcription. Only symbiosis with the native symbiont Breviolum minutum decreased the abundance of pro-inflammatory 9(R)-hydroxy-octadecadienoic acid (9(R)-HODE) in the host. In contrast, symbiosis with the non-native symbiont Durusdinium trenchii was marked by higher abundance of autoxidation-derived octadecanoids, corroborating previous evidence for cellular stress in this association. The putative octadecanoid signaling pathways reported here suggest foundational knowledge gaps that can support the bioengineering and selective breeding of more optimal host-symbiont pairings to enhance resilience and survival of coral reefs.
Development and Iodine Testing of a Novel C12A7 Electride Planar Hollow Cathode
Authors: Becke Philipp S. , Kottke Nils Gerrit , Vaupel Max , Kutufa Niccola , Wätzig Katja , Tajmar Martin , Hey Franz Georg 
Published: January 2025

Abstract

Iodine exhibits promising characteristics as a propellant for electric propulsion (EP) systems. Its performance is comparable to xenon, yet it offers significant cost advantages. Moreover, it can be stored in a compact solid state and easily fed into the system through sublimation. Thruster operation has already been successfully demonstrated for the iodine fed Advanced Cusp Field Thruster, Hall Effect Thrusters and Radiofrequency Ion Thrusters (RIT), with the first in-space demonstration for an iodine RIT in early 2021. However, an iodine-fed plasma-bridged hot neutraliser is required to unlock the full systemic potential of an iodine EP subsystem at higher current levels. There exists no high-current iodine-fed neutraliser so far, as the corrosive nature of iodine and the potential for emitter material poisoning pose challenges. In the framework of the “IcoN” activity, a planar hollow cathode based on a C12A7 electride emitter has been developed and tested. The emitter has been manufactured by Fraunhofer IKTS, the neutraliser was manufactured and tested at Airbus Friedrichshafen. The initial testing was done with krypton and changed to iodine, as soon as a reliable cathode performance was achieved. After the first iodine tests were completed, the feed system was updated with a proportional valve to allow better control of the flow rate. In the final test series, two different emitter types and two planar cathode configurations have been tested with iodine. The longest achieved stable discharge was 26 minutes. While it was possible to develop a fully functional iodine feed system and a novel heaterless planar cathode based on C12A7 electride for krypton, no long-time stable iodine discharge was achievable in the frame of the project.
Recurrent horizontal gene acquisition in the evolutionary history of ants
Authors: Schrader Lukas , Rinke Janina , He Ding , Vizueta Joel , Larsen Rasmus , Xiong Zijun , Gadau Jürgen , Zhang Guojie , Boomsma Jacobus 
Published: January 2025

Abstract

Horizontal Gene transfer (HGT) from bacteria has often led to Horizontal Gene Acquisition (HGA), subsequently contributing to phenotypic innovation. Ants are interesting potential targets for HGA because they host many mutualistic associations with vertically transmitted symbionts, but the overall prevalence of HGA across the ants and other insect lineages remains virtually unexplored. Here, we systematically screened the genomes of 163 ant species and identified 497 HGA events of protein-coding genes, predominantly derived from intracellular symbionts, in 85 species belonging to eight subfamilies. Apart from convergent horizontal transfers of Wolbachia-derived ankyrin repeat proteins into the genomes of 45 ant species, we identified dozens of other HGAs that likely offered adaptive innovations of phenotypic functions, primarily mediating immune-system adaptations or facilitating nutritional niche expansions. We provide in-depth characterizations of multiple clade- and species-specific HGAs, some as old as 40 MY, consistent with strong evolutionary conservation. Our study is the first of its kind in ants and considerably expands our general appreciation of the
evolutionary significance of HGA from bacteria to eukaryotes.
STARGATE: An Undergraduate Experimental Electric Propulsion Student Research Project
Authors: Blue Claude , Calhoun Sydney , Shiffer Christopher , Milivojevic Noah 
Published: January 2025

Abstract

This paper reports on the ongoing investigation regarding the feasibility of utilizing the Corona Discharge Reaction as an alternative plasma production mechanism in a Gridded Ion Thruster system. The STARGATE project investigated and demonstrated the difference between negative and positive Corona Discharge Reactions as it pertains to electric propulsion applications, as well as investigated the feasibility of utilizing the Corona Discharge Reaction for plasma production in its intended operating environment. The team has designed and fabricated an initial functional vacuum testing prototype, and is pending initial test-firing.
Analysis of Lymph Node Metastasis and Risk Factors in 424 Patients with low-grade endometrioid carcinoma
Authors: Cao Lina , Lu Xiaoyuan , Wang Yijun , Wang Luyao 
Published: January 2025

Abstract

Purpose: To explore the lymph node metastasis (LNM) of low-grade endometrioid carcinoma (EEC) and its related risk factors, and to analyze the efficacy of related risk factors in predicting LNM.
Methods: Data of 424 EEC patients who underwent endometrial cancer staging surgery from January 2019 to June 2024 were retrospectively analyzed. Univariate and multivariate logistic regression were used to analyze the related factors of LNM. The receiver operating characteristic (ROC) curve was drawn to analyze the efficacy of related independent risk factors in predicting LNM.
Results: The rate of LNM was 7.8% (33/424). Univariate analysis showed that histological grade, tumor size, depth of myometrial, cervical stromal, lymphovascular space invasion (LVSI), microcystic, elongated, fragmented (MELF), carbohydrate antigen 125 (CA125), carbohydrate antigen 199 (CA199)and human epididymis protein 4 (HE4) were associated with LNM of EEC. Logistic regression analysis showed that LVSI, MELF, depth of myometria and CA125were independent risk factors for LNM. The ROC curve area of CA125 and depth of myometria was 0.796 and 0.734. The best cut-off point of CA125 was 31.36 (U/mL), corresponding to the largest Youden index of 53.9%, and its positive likelihood ratio was 5.2. The accuracy of diagnosing LNM by combining CA125 and depth of myometrial is higher than that of either alone.
Conclusions: LNM is more likely to occur when there are risk factors such as LVSI positive, MELF invasion pattern, myometrial invasion depth ≥50% and CA125. The accuracy of CA125 combined with depth of myometrial in the diagnosis of LNM is higher than that of either alone. This study has a certain reference value for predicting the risk of LNM and stratified management and treatment for EEC patients.
Blue Economy: Blessing of the sustainable growth in Tunisia
Authors: Saghrouni Olfa 
Published: January 2025

Abstract

The Blue economy in Tunisia is an opportunity to achieve integrated and sustainable development. Fundamental relationships between different macroeconomic variables may follow certain common theories, but local preferences are also decisive in determining their unique behavior. Looking into Blue Economic growth nexus is, therefore, needed in Tunisia, so as to understand the long -run economic stance and to capture the short-run dynamics in the national economy. This paper aims to analyze the impact of Blue Economic and economic growth in Tunisia using time series data over the period 2002 to 2022. This study is based on the Auto-Regressive Distributive Lags (ARDL) approach that is proposed by Pesaran et al (2001). Blue Economic are important for economic growth and economic growth has an impact in Tunisia. A successful and sustained economic growth requires growth in Blue Economic.
JEL classification: O4, Q56, R11
Cost-Benefit Analysis of Pre-Entry Tuberculosis Screening Policy: Nepalese and Japanese Perspectives
Authors: Iwaki Yoko , Hayashi Takayuki , Nomura Shuhei , Shimamura Shoko , Gauchan Rohita , Huang Michael C. 
Published: January 2025

Abstract

Objectives:This study examined the cost and benefit impact of the introduction of pre-entry tuberculosis (TB) screening policy, including testing and treatment for Japan and Nepal from 2014 to 2018.
Methods:This study used data from the Nepal Demographic and Health Survey; and from Japan’s Legal Affairs Bureau and Tuberculosis Surveillance Center. We used cost-benefit analysis to examine the effect of the pre-entry TB screening policy. Total cost, total benefit and net benefit for both countries were compared for the policy scenarios “With” and “Without”, using net present value (NPV). In order to address parameter difference for uncertainty, we conducted sensitivity analysis using Monte Carlo simulation with secondary transmission rate.
Results: Between 2014 and 2018 in Japan, NPV of Nepalese student increased from USD 1.9 million to USD 2.9 million; likewise, NPV of Nepalese workers grew from USD 1.1 million to USD 3.0 million. The increase in NPV was greater than zero, meaning that the implementation of the policy could produce a benefit for Japan regarding prevention of increase in number of new TB cases. In Nepal, the predicted number of foreign migrant applicants with newly diagnosed TB increased. Total NPV for Nepal was negative since total cost was greater than the benefit, suggesting added burden of direct TB cost.
Conclusions: Implementation of pre-entry TB screening policy for foreign migrants arriving in Japan from Nepal with high TB burden would achieve efficient cost-saving through reduction of number of newly diagnosed TB cases including those with transmission risk.
Diagnostic and prognostic value of deregulated miR-493-5p in patients with severe pneumonia
Authors: Liu Lili , Han Lei , Zhao Huan , Wang Liying 
Published: January 2025

Abstract

Background
A large number of studies have shown that microRNAs (miRNAs) are closely associated with pneumonia.
Aims
This study endeavors to explore the expression levels and clinical significance of miR-493-5p in pediatric patients diagnosed with severe pneumonia.
Methods
A total of 125 children diagnosed with severe pneumonia and 100 children with common pneumonia were enrolled in this study, alongside 100 healthy children who served as controls. Real-time quantitative PCR was used to was used to detect gene expression levels. The receiver operating characteristic curve was used to evaluate the diagnostic value of miR-493-5p in children with severe pneumonia. Kaplan-Meier and COX regression analyses were used to evaluate the prognostic value of miR-493-5p in children with severe pneumonia. Pearson correlation analysis was used for correlation analysis. Furthermore, pneumonia model cells were constructed in vitro to explore the underlying mechanism of miR-493-5p in severe pneumonia.
Results
Serum miR-493-5p was highly expressed in children with severe pneumonia. miR-493-5p has a certain diagnostic value for severe pneumonia and is related to the prognosis of the disease. miR-493-5p is positively correlated with the levels of inflammatory factors in children with severe pneumonia. miR-493-5p affects the function and inflammation of pneumonia model cells. IRF1 could partially reverse the effect of miR-493-5p on MRC-5 cell.
Conclusions
The level of miR-493-5p has a certain value in the diagnosis and prognosis of children with severe pneumonia, and it may play a critical role in the disease process and associated inflammatory responses by targeting the IRF1.
Anxiety symptom and relationship to pain, functional disability and quality of life among spinal deformity patients scheduled for surgery: a prospective cross-sectional study
Authors: Zhang Jiaqi , Mei Yanan , Zeng Yan , Li Weishi , Guo Meihan , Sun Yuting , Wang Mingchun , Yue Lina 
Published: January 2025

Abstract

Purpose
To assess the prevalence, severity and association of anxiety symptom with pain, disability and quality of life (QoL) in spinal deformity diseases (SDD) patients, and to compared with common degenerative spinal diseases (DSD).
Methods
A total of 304 patients scheduled for spinal surgery were included in the analysis, of which 184 patients were diagnosed as various SDD and 120 were common DSD. HRQoL assessment included VAS, ODI and SF-12v2. The State-Trait Anxiety Inventory (STAI) was used to evaluated anxiety symptom. The SDD were further divided into two subgroups according to symptom severity: mildly symptomatic spinal deformity (NSSD) with VAS ≤ 3 and ODI ≤ 20; significantly symptomatic spinal deformity (SSSD) with VAS > 3 or ODI > 20. Bivariate correlation analysis was conducted by spearman correlation. Hierarchical regression analysis was further performed for QoL of SDD.
Results
The high anxiety symptom accounted for 68.3%, 51.2% and 49.2%, respectively in the SSSD, MSSD and DSD patients (p = 0.009). The SSSD had significantly higher scores of STAI-S, STAI-T and STAI-Total compared to the DSD, and significantly higher STAI-S than MSSD. Anxiety severity showed significantly positive correlations with VAS and ODI as well as negative correlations with MCS, PCS and SF-12 total scores. Age, educational level, financial burden, disability and trait-anxiety symptoms were independently associated with the QoL of SDD patients.
Conclusions
Psychosocial factors were important correlates of QoL in spinal deformity patients and a broader biopsychosocial view is necessary in the treatment of spinal deformity patients.
Dyna-P: Placement-aware Dynamic Partitioning for Lightweight Applications with Modern GPUs
Authors: Adufu Theodora , Kim Yoonhee 
Published: January 2025

Abstract

Efficient GPU resource sharing is critical in dynamic cloud-based environments, particularly for lightweight HPC applications and Small Language Models, which demand partial GPU resources for execution. However, traditional scheduling frameworks fail to address intra-GPU and inter-node resource fragmentation and dynamic placement challenges arising from the heterogeneity in each application's resource demand and job completion times. This leads to resource under-utilization and scheduling delays in GPU clusters. This paper introduces Dyna-P, a novel scheduling framework designed to dynamically adjust GPU partitions to minimize resource fragmentation while improving system throughput and Makespan. Dyna-P proposes a Reconfiguration Last Policy which recognizes that workloads consisting of lightweight applications can benefit more from uninterrupted execution. Experimental results demonstrate that Dyna-P improves average throughput by up to 14.7% and reduces Makespan by 39% compared to state-of-the-art methods. These findings underscore Dyna-P’s potential to improve resource allocation rates in multi-tenant GPU environments
Assessing the Efficacy and Safety of the Allurion® Gastric Balloon in Latin American Patients: A Multicenter Case Series
Authors: Muriel María Emilia , García Manuel , Lascano Fernando Martinez , Vamvakianos Pablo Nicolas Martinez , Sosa Matias Facundo , Castellaro Pablo Javier , Sepulveda Matias , Palermo Mariano , Piatanesi Maria de la Paz , Argonz Julio Ernesto , Puentes Maria Eleonora , Awruch Diego , Tioni Rogelio , Gancedo María Clotilde , Ferraro Ariel , Baracco Arianna Sibila Portmann , Garland Luciano Poggi , Esqu Carlos 
Published: January 2025

Abstract

Introduction
Allurion® gastric balloon (AGB) is an innovative option for treating overweight and grade I obesity or as a bridging treatment for bariatric surgery or because the patient does not desire a surgical intervention. This study aimed to evaluate the efficacy and safety of the AGB in a multicentric cohort.
Materials and methods
A retrospective analysis of consecutive cases treated with AGB (≥18 years old with BMI ≥27) was performed in eight centers in 3 countries in Latin America (Argentina, Chile, and Peru), between September 2021 to September 2022, with a 12-month follow-up.
Results
402 patients were included (median BMI of 32.81 kg/m2). Mean TWL% was 8.3%, 11.6%, and 14.9% at 3, 6, and 12 months respectively, with a follow-up of 93.03%, 75.37% and 40.54%. The adverse event rate was 1.24% (n=5). During the first 7 days, 34.58% (n=139) experienced concomitant symptoms, and 1.99% (n=8) asked for endoscopic balloon extraction because of intolerance. The complication rate was 6.46% (n=26). Readmission index was 4.97% (n=20) and reintervention was 2.23% (n=9). Balloon elimination was experienced by 5.7% of patients in the first 14 days, 29.10% (n=117) before the 3rd month, and 62.68% (n=252) after the 16th week. Early deflation rate was 2.73% (n=11). Digestive track elimination was perceived by 26.61%.
Conclusions
AGB is a safe and effective option for the treatment of overweight and obesity in Latin America. Lifestyle changes and continuous support with a multidisciplinary team are essential to achieving good mid- to long-term outcomes.
Accuracy and Reliability of 3D Cephalometric Landmark Detection with Deep Learning
Authors: Liu Boyan , Liu# Chang , Xiong Yutao , Zhu Hailin , Zeng Wei , Guo Jixiang , Liu Wei , Tang Wei , Chen Jinglong 
Published: January 2025

Abstract

Objective: Three-dimensional (3D) landmark detection is essential for assessing craniofacial growth and planning surgeries such as orthodontic, orthognathic, traumatic, and plastic procedures. This study aimed to develop an automatic 3D landmarking model for oral and maxillofacial regions and to validate its accuracy, robustness, and generalizability in both spiral computed tomography (SCT, 41 landmarks) and cone-beam computed tomography (CBCT, 14 landmarks) scans.
Methods: The model was constructed using an optimized lightweight 3D U-Net network architecture. Its accuracy, robustness, and generalizability were thoroughly evaluated and validated through a multicenter retrospective diagnostic study. The internal dataset included 480 SCT and 240 CBCT cases. For external validation, 320 SCT and 150 CBCT cases were assessed using mean radial error (MRE) and success detection rate within 2-, 3-, and 4-mm error thresholds as the primary evaluation metrics. Error analyses for landmark detection along each coordinate axis were performed. Consistency tests among index observers were conducted.
Results: The average MRE for both SCT and CBCT was consistently below 1.3 mm and, notably, below 1.4 mm in complex conditions such as malocclusion, missing dental landmarks, and the presence of metal artifacts. No significant differences in MRE and SDR at 2-4 mm were observed between external and internal SCT and CBCT sets. SCT bone landmarks were more precise than dental ones, with no difference between bone/soft tissue and dental/soft tissue. CBCT dental landmarks exhibited greater precision compared to bone landmarks. A detailed error analysis across the coordinate axes showed that the coronal axis had the highest error rates. The implementation of this model significantly improved the landmarking proficiency of senior and junior specialists by 15.9% and 28.9%, respectively, while also accelerating the process by a factor of 6 to 9.5 times.
Conclusions: This study shows that the AI-driven model delivers high-precision 3D localization of oral and maxillofacial structures, even in complex scenarios. The model can aid specialists across all experience levels in conducting accurate and efficient localization analyses, owing to its strong clinical utility, robustness, and generalizability.
Clinical Relevance: 3D cephalometric landmark detection is crucial for assessing craniofacial growth and planning diverse surgical procedures, such as orthodontic, orthognathic, trauma, and aesthetic interventions. The traditional manual landmark identification is time-consuming and requires significant expertise. This proposed AI method provides accurate measurements for both soft and hard tissues, streamlines digital planning, decreases reliance on expert knowledge, and enhances the efficiency and success of treatments.
RPA: A Performer-Based Retinex Model for Low-Light Image Enhancement
Authors: Shao Yunxue , Diao Yijin , Wang Lingfeng 
Published: January 2025

Abstract

In low-light scenarios, especially under high dynamic range (HDR) conditions, existing low-light image enhancement algorithms face significant challenges, such as over-enhancement of brightness, loss of details in high-light regions, and undesirable color distortions, which severely hinder their performance. To address these limitations, we propose an improved low-light image enhancement algorithm, Retinexformer on Performer Attention (RPA). By incorporating more efficient Performer Attention and relative position encoding, RPA enhances the model's capability to capture long-range global information and model local dependencies. The proposed framework comprises two key modules: a light decomposition module that generates illumination maps to brighten the image and a damage restoration module that leverages Relative-Performer Multi Self Attention (RPMSA) to refine image quality. Extensive experiments on six paired datasets and three unpaired datasets qualitatively and quantitatively demonstrate the effectiveness and generalization ability of RPA. Visually, it effectively suppresses high-light overexposure and preserves details and color consistency in more complex HDR environments, resulting in more natural enhancement effects. This study provides a novel perspective for low-light image enhancement. Code is available at https://github.com/JJCcxk/RPA.