bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quality-adjusted time without symptoms or toxicity analysis of nivolumab plus chemotherapy versus chemotherapy alone for the management of previously untreated patients with advanced gastric cancer, gastroesophageal junction cancer, or esophageal adenocarcinoma
Authors: Lin Daniel , Nguyen Hiep , Shah Ruchit , Qiao Yao , Hartman John , Sugarman Ryan 
Published: March 2023

Abstract
Background
The phase 3 CheckMate 649 established superior overall survival of nivolumab in combination with chemotherapy (NIVO + chemo) compared with chemotherapy (chemo) alone as a first-line treatment for patients with Her2-negative advanced gastric cancer, gastroesophageal junction cancer, and esophageal adenocarcinoma (GC/GEJC/EAC). This post hoc trial analysis aimed to evaluate the benefit of NIVO + chemo using quality-adjusted time without symptoms or toxicity (Q-TWiST) to further account for quality of life (QoL) in different health states depending on disease progression and treatment toxicity.

Methods
Using data from CheckMate 649, we evaluated the quality-adjusted survival gain associated with NIVO + chemo compared with chemo alone among all randomized patients and repeated similar analyses among those with programmed cell death-ligand 1 (PD-L1) combined positive score (CPS) ≥ 5. Relative Q-TWiST gains of ≥ 10% were predefined as clinically important.

Results
In all randomized patients, those receiving NIVO + chemo had a mean Q-TWiST gain of 1.8 (95% CI 0.9, 2.7) months compared with those receiving chemo alone. The relative Q-TWiST gain was estimated to be 12.8%. Patients with PD-L1 CPS ≥ 5 had greater quality-adjusted survival gain from NIVO + chemo with an estimated Q-TWiST gain of 2.8 (95% CI 1.5, 4.1) months, representing a relative gain of 20.6%. Subgroup analyses and sensitivity analyses with various QoL utility values yielded consistent findings in favor of NIVO + chemo compared with chemo alone. Q-TWiST gain from NIVO + chemo increased with longer duration of follow-up.

Conclusions
NIVO + chemo was associated with a statistically significant and clinically important gain in quality-adjusted survival compared with chemo alone among previously untreated patients with advanced GC/GEJC/EAC.
Absence of song suggests heterogeneity of vocal-production learning in hummingbirds
Authors: Monte Amanda , da Silva Maria Luisa , Gahr Manfred 
Published: March 2023

AbstractHummingbirds have been recognized, along with songbirds and parrots, as capable of learning songs. However, it is still unclear whether singing can be treated as a homologous trait within the family, analogous to songbirds. Therefore, we systematically compared the information about hummingbird vocalizations in the literature in a phylogenetic framework. In general, songs were emitted by perching males in a reproductive context, while calls were mainly in agonistic contexts. Singing was ancestral in most of the nine major hummingbird clades, but has been lost at least once in the mountain gem clade and twice in the bee clade. This evolutionary loss of singing might suggest heterogeneity of vocal-production learning.
Simulation of blind pre-diction and post-diction shaking table tests on a masonry building aggregate using a continuum modelling approach
Authors: Aşıkoğlu Abide , D’Anna Jennifer , Ramirez Rafael , Solarino Fabio , Romanazzi Antonio , Ciocci Maria Pia , Bianchini Nicoletta 
Published: March 2023

AbstractMasonry buildings of historical centres are usually organized within aggregates, whose structural performance against seismic actions is challenging to predict and constitutes still an open issue. The SERA—AIMS (Seismic Testing of Adjacent Interacting Masonry Structures) project was developed to provide additional experimental data by testing a half-scale, two-unit stone masonry aggregate subjected to two horizontal components of dynamic excitation. In this context, this paper investigates the reliability of the modelling approach and the assumptions adopted to generate a three-dimensional continuum finite element model. The work involves two stages, namely a blind pre-diction and a post-diction phase, and proposes a series of simulation analyses including a strategy to shorten the actual records and save computation costs. The study was performed to investigate the extent of uncertainty in modelling for such masonry aggregates in relation to the experimental outcomes. Pre-diction results were proven to be not accurate in terms of predicted displacements and damage patterns. The upgrades introduced for the post-diction analyses, including the calibration of the elastic modulus and the introduction of a non-linear interface between the two units, allowed to improve the outcomes, with reasonable results in terms of predicted base shear force, displacements along Y-direction and damage pattern for the non-linear stage. The overall approach showed to be appropriate for the structural analysis of existing masonry aggregates, but the accurate modelling of this type of structure remains challenging due to the high level of uncertainties.
Event-Driven Serverless Pipelines for Video Coding and Quality Metrics
Authors: Moina-Rivera Wilmer , Garcia-Pineda Miguel , Claver Jose M. , Gutiérrez-Aguado Juan 
Published: March 2023

AbstractNowadays, the majority of Internet traffic is multimedia content. Video streaming services are in high demand by end users and use HTTP Adaptive Streaming (HAS) as transmission protocol. HAS splits the video into non-overlapping chunks and each video chunk can be encoded independently using different representations. Therefore, these encode tasks can be parallelized and Cloud computing can be used for this. However, in the most extended solutions, the infrastructure must be configured and provisioned in advance. Recently, serverless platforms have made posible to deploy functions that can scale from zero to a configurable maximum. This work presents and analyses the behavior of event-driven serverless functions to encode video chunks and to compute, optionally, the quality of the encoded videos. These functions have been implemented using an adapted version of embedded Tomcat to deal with CloudEvents. We have deployed these event-driven serverless pipelines for video coding and quality metrics on an on-premises serverless platform based on Knative on one master node and eight worker nodes. We have tested the scalability and resource consumption of the proposed solution using two video codecs: x264 and AV1, varying the maximum number of replicas and the resources allocated to them (fat and slim function replicas). We have encoded different 4K videos to generate multiple representations per function call and we show how it is possible to create pipelines of serverless media functions. The results of the different tests carried out show the good performance of the serverless functions proposed. The system scales the replicas and distributes the jobs evenly across all the replicas. The overall encoding time is reduced by 18% using slim replicas but fat replicas are more adequate in live video streaming as the encoding time per chunk is reduced. Finally, the results of the pipeline test show an appropriate distribution and chaining among the available replicas of each function type.
María Teresa Miras Portugal: a pioneer in the study of purinoceptors in chromaffin cells
Authors: Artalejo Antonio R. , Arribas-Blázquez Marina , Barahona María Victoria , Llorente-Sáez Celia , Olivos-Oré Luis Alcides 
Published: March 2023

AbstractMaría Teresa Miras Portugal devoted most of her scientific life to the study of purinergic signalling. In an important part of her work, she used a model system: the chromaffin cells of the adrenal medulla. It was in these cells that she identified diadenosine polyphosphates, from which she proceeded to the study of adrenomedullary purinome: nucleotide synthesis and degradation, adenosine transport, nucleotide uptake into chromaffin granules, exocytotic release of nucleotides and autocrine regulation of chromaffin cell function via purinoceptors. This short review will focus on the current state of knowledge of the purinoceptors of adrenal chromaffin cells, a subject to which María Teresa made seminal contributions and which she continued to study until the end of her scientific life.
Studies on Argentine Phylacia species (Hypoxylaceae) using a polythetic taxonomic approach
Authors: Lambert Christopher , Schiefelbein Rahel , Jaimez Javier A. , Stadler Marc , Sir Esteban B. 
Published: March 2023

AbstractThe current study is dedicated to the taxonomy of the genus Phylacia (Hypoxylaceae) in Argentina. Fieldwork in the north of the country provided several fresh collections that were studied, using a polyphasic approach. The secondary metabolite profiles of the specimens were generated by high-performance liquid chromatography hyphenated by diode array and mass spectrometry (HPLC–DAD/MS) of the stromata. This study confirmed the presence of secondary metabolites that are also found in the related genus Daldinia. The detection of binapththalene tetrol (BNT), daldinal B, and daldinol, which are also characteristic of certain species of Daldinia and Hypoxylon, further confirmed the chemotaxonomic affinities within the Hypoxylaceae. The phylogenetic affinities of several species were determined using a multi-gene genealogy based on ITS, LSU, TUB2, and RPB2 sequences, confirming that Phylacia is most closely related to Daldinia, Rhopalostroma, and Thamnomyces. The new species P. lobulata, which features a rather unique stromatal morphology and seems to exhibit apparent host specificity for the endemic tree Pseudobombax argentinum, is described.
E-commerce channel management on the manufacturers’ side: ongoing debates and future research pathways
Authors: Ballerini Jacopo , Yahiaoui Dorra , Giovando Guido , Ferraris Alberto 
Published: March 2023

AbstractSince the beginning of the 2000s, online commerce has been gradually taking over and shaping the global marketplace. This has led several scholars to study the phenomenon from different angles, from consumer habits to privacy risks to related technological innovations. However, only recently has a branch of literature addressing the online channel management phenomenon from the manufacturers’ perspective emerged. This rapidly expanding literature strand remains rather fragmented, raising the need for a systematic literature review to comprehensively structure and discuss it. This study, accordingly, proposes a systematic literature review on online channel management from the manufacturers’ perspective. Firstly, it provides relevant bibliometric insights into the ongoing research on the topic. Secondly, applying the bibliographic coupling methodology individuates 92 interconnected contributions published by 31 December 2021. Three different, albeit interconnected, thematic clusters are discovered and reviewed, revealing their focus on (a) strategic marketing issues around manufacturervsretailer conflict, (b) pricing policies and trade-offs among pricevsservices, and (c) operational interactions and strategies between supply chain members. Finally, after a systematic literature review the authors develop thirteen original research propositions concerning new research pathways and theoretical advancements to be designed and implemented.
Meeting the challenges of wild boar hunting in a modern society: The case of France
Authors: Vajas Pablo , Von Essen Erica , Tickle Lara , Gamelon Marlène 
Published: March 2023

AbstractModern hunting is an ambivalent practice, torn between leisure and labor. Nowhere are these conflicting dimensions better manifested than for wild boar—a simultaneous game and pest species in many countries. Here, we consider the sociological, political and cultural phenomenon of wild boar hunting from a change perspective, starting at its historical roots to future implications concerning the changing demographics, drivers, needs and practices of a modernizing hunting community. Using the case context of France, we present an approach to deconstructing each component of wild boar hunting firstly, and subsequently the external forces that change the nature of hunting. The objective of this manuscript is to discuss of the wild boar optimal harvesting to be applied in changing social and ecological environment. Findings show that the challenges facing wild boar management will likely intensify in the future, especially under the spotlight of a controversial public debate.
Differentiation of integral Mittag-Leffler and integral Wright functions with respect to parameters
Authors: Apelblat Alexander , González-Santander Juan Luis 
Published: March 2023

AbstractDerivatives with respect to the parameters of the integral Mittag-Leffler function and the integral Wright function, recently introduced by us, are calculated. These derivatives can be expressed in the form of infinite sums of quotients of the digamma and gamma functions. In some particular cases, these infinite sums are calculated in closed-form with the help of MATHEMATICA. However, parameter differentiation reduction formulas are explicitly derived in order to check some of the results given by MATHEMATICA, as well as to provide many other new results. In addition, we present these infinite sums graphically for particular values of the parameters. Finally, new results for parameter derivatives of the Mittag-Leffler and Wright functions are reported in the Appendices.
Particle Number Emission for Periodic Technical Inspection in a Bus Rapid Transit System
Authors: Botero Maria L. , Londoño Javier , Agudelo Andrés F. , Agudelo John R. 
Published: March 2023

AbstractThis study was carried out under the Climate and Clean Air in Latin American Cities program (CALAC+) and aimed to evaluate the particle-number-based periodic technical inspection (PN-PTI) test in a public bus rapid transport (BRT) system and establish a baseline of PN emission. The PN-PTI test was performed in 1474 buses with emission standards from Euro II to Euro V without diesel particle filter (DPF), Euro V with retrofitted DPF, Euro VI diesel with original engine manufacturer DPF, and compressed natural gas (CNG) fueled. The median PN emission of buses with DPF is below 3000 #/cm3. PN emission limits such as 1,000,000 #/cm3 or 250,000 #/cm3 would allow the approval of vehicles with DPF that are not fully operational. An additional high-idle test is proposed for buses with emissions above 50,000 #/cm3, but below the test approval limit, to detect DPF that may require maintenance.For buses without DPF, which are the majority of the bus fleets in Latin America, the PN emission test can detect and target very-high emitters for developing special policies. CNG buses presented the lowest emissions, likely because of the detection limit of the equipment (23 nm) which cannot detect the large number of particles emitted by these vehicles in the sub-23 nm particle range.
Virtuelle Flurgespräche und Status-Updates: Zusammenarbeit in avatar-basierten Arbeitsumgebungen
Authors: Oehring Felix , Feufel Markus A. , Mörike Frauke 
Published: March 2023

ZusammenfassungDer vorliegende Beitrag beschäftigt sich mit der Zusammenarbeit von hybrid arbeitenden Teams in avatar-basierten virtuellen Büroumgebungen. Ausgehend von den drei Dimensionen der Virtualität gehen wir folgenden Forschungsfragen nach: (1) Wie wird der Arbeitsalltag und die Zusammenarbeit in diesen Umgebungen koordiniert? und (2) Welche Vorteile und Herausforderungen sehen Nutzer*innen in Bezug auf avatar-basierte Arbeitsumgebungen? Auf Basis einer multi-methodischen Studie bestehend aus qualitativen Interviews mit erfahrenen Nutzer*innen und einer partizipativen Fokusgruppendiskussion mit neuen Nutzer*innen zeigen wir, dass Zusammenarbeit in avatar-basierten Arbeitsumgebungen in vielfältigen Arbeitsformen – von Ko-Präsenz bis zum mobilem Arbeiten – stattfindet und dass für die Koordination dieser Arbeitsmodi vielversprechende Ansätze zur Verfügung stehen. Unsere Ergebnisse zeigen aber auch, dass für die Ausschöpfung dieses Potentials nicht nur die virtuellen Umgebungen selbst, sondern auch die kollaborativen Arbeitsformen und die digitale Infrastruktur von Teams konsequent weiterentwickelt werden müssen.Praktische Relevanz: Die Studie untersucht Virtualität anhand einer aktuell nutzerbaren, avatar-basierten Arbeitsumgebung und zeigt die Perspektiven erfahrener und neuer Nutzer*innen auf Zusammenarbeit innerhalb dieses soziotechnischen Arbeitssystems auf. Insbesondere werden konkrete kollaborative Arbeitspraktiken vorgestellt und deren Herausforderungen diskutiert, um potenziellen Nutzer*innen, die virtuelle Arbeitsumgebungen selbst anwenden möchten, eine Orientierung zu bieten.
Geburtshilfliche Blutungen
Authors: Dadak Christian 
Published: March 2023

ZusammenfassungBlutungen zählen zu den häufigsten Todesursachen von Frauen während der Schwangerschaft und innerhalb des darauffolgenden Jahrs. Dies gilt für die industrialisierte Welt, aber ganz besonders für Länder mit niedrigem Einkommensschnitt. Die meisten mütterlichen Todesfälle wären vermeidbar.
Role of silt and clay fractions in organic carbon and nitrogen stabilization in soils of some old fruit orchards in the Nile floodplain, Sohag Governorate, Egypt
Authors: Thabit Fatma N. , El-Shater Abdel-Hamid , Soliman Wafaa 
Published: March 2023

Abstract
Purpose
Study the effect of both silt and clay fractions on stabilizing organic carbon and total nitrogen in soils of some old cultivated fruit orchards in Sohag, Egypt.

Methods
Eleven surface soil samples (0–15 cm) were collected. Silt (63–2 μm) and clay (< 2 μm) fractions were separated from soils and analyzed for cation exchange capacity (CEC), organic carbon (OC), total nitrogen (TN), specific surface area (SSA), X-ray diffraction (XRD) and Fourier Transform Infrared (FTIR) spectroscopic analysis were determined using the standard analysis methods.

Results
The silt and clay were responsible for 77.49 to 93.34% of soil CEC. The SSA of clay was twice the silt, and the phyllosilicates (%) average was 29.83% and 62.70% in silt and clay. Other minerals, such as quartz, feldspar, and carbonate minerals, were detected in these fractions. The phyllosilicate species of clay were smectite-illite mixed layers (44.4–88.9%), Smectite (1.0–6.4% except one sample recorded 45.7%), Kaolinite (3.7–10.5%) and kaolinite/smectite mixed layers (2.0–8.2%). The average OC-silt and clay were 6.79 and 8.96 g OC kg−1 soil (38.01 and 50.28% of soil OC). On average, the total nitrogen (TN) in silt and clay particles was 0.817 and 1.156 g N kg−1 soil (35.88 and 50.66% of soil TN). The OC and N content significantly and positively correlated with CEC, SSA, and phyllosilicates in the fine fractions.

Conclusion
Results showed that the soil's capacity to sequester OC and N is affected significantly by its fine particles' content, characteristics, and mineralogy.
Amphetamine-induced prolonged disturbances in tissue levels of dopamine and serotonin in the rat brain
Authors: Taracha Ewa , Czarna Magdalena , Turzyńska Danuta , Maciejak Piotr 
Published: March 2023

Abstract
Background
A hallmark of psychostimulants is the persistence of neurobiological changes they produce. The difficulty in reversing long-time effects of psychostimulants use is why addiction therapy is so ineffective. This study aimed to look for such drug-induced changes that can be detected even after many weeks of abstinence.

Methods
Rats were given 12 doses of amphetamine (Amph) at 1.5 mg/kg. The rewarding effect of Amph was assessed using ultrasonic vocalization. After 14 and 28 days of abstinence, tissue levels of dopamine (DA), serotonin (5-HT), and their metabolites were measured in the prefrontal cortex (PFC), nucleus accumbens (Acb), dorsomedial (CPuM), and dorsolateral (CPuL) striatum.

Results
After 28 days of abstinence, DA levels were increased in the dorsal striatum while 5-HT levels were decreased in all brain regions studied. The opposite direction of changes in DA and 5-HT tissue levels observed in the dorsal striatum may be related to the changes in the emotional state during abstinence and may contribute to the incubation of craving and relapses. Tissue levels of 5-HT and DA showed intra- and inter-structural correlations, most pronounced after 14 days of abstinence. Most of them were absent in the control group (ctrl), which may indicate that their appearance was related to the changes induced by earlier Amph administration. We did not find any associations between reward sensitivity and the persistence of Amph-induced neurochemical disturbances.

Conclusions
Administration of 12 moderate doses of Amph causes prolonged changes in DA and 5-HT tissue levels. The direction and severity of the changes are dependent on the brain region and the neurotransmitter studied.
ECRA thruster advances: 30W and 200W prototypes latest performances
Authors: Désangles Victor , Packan Denis , Jarrige Julien , Peterschmitt Simon , Dietz Patrick , Scharmann Steffen , Holste Kristof , Klar Peter J 
Published: March 2023

AbstractThe H2020 MINOTOR project focused on the study and the optimization of the ECRA thruster, an electric propulsion system for satellites. First, a 30 W prototype of this Electron Cyclotron Resonance Thruster (ECRT) is optimized. Then, a 200 W prototype is design based on these findings. The performances of both prototypes were assessed at two different facilities: at ONERA in France and at Justus Liebig University in Germany. Significant improvement of performances of both thrusters with the decrease of background pressure is presented. Total thrust efficiencies as high as 50% are measured at JLU, as well as erosion and lifetime assessment. The stability of the thruster for a constant point of operation was measured for one hundred hours of operation.
Competitive programming participation rates: an examination of trends in U.S. ICPC regional contests
Authors: Blum Jeremy J. 
Published: March 2023

AbstractA wide range of benefits have been posited from participation in competitive programming contests. However, an analysis of participation in north American regional contests in the International Collegiate Programming Contest (ICPC) shows that participation in these contests is sharply declining, coinciding with the COVID-19 pandemic. Moreover, prior to the pandemic, while the number of teams participating in regional contests was increasing, the number of institutions sending teams to these contests was declining. We find several statistically significant correlations that may underscore structural reasons for this trend. Consistent participation in contests and the number of teams per institution sent to a contest both are correlated with likely participation in future contests. On the other end of the spectrum, institutions sending a team to a contest for the first time in 3 years were much less likely to return in the next year. For this category of teams, if a team is unable to solve any problems in the contest, the institution is significantly less likely to send a team in the next year. Many of these contests have very challenging problem sets, and consequently, have many teams that fail to solve any problems. This result suggests that structuring the problem sets to increase the likelihood that most teams successfully complete problems would broaden participation in these contests.