bluuebunny/crossref_metadata_2025_split huggingface dataset:
SLIM‐FLOOR BEAM‐TO‐COLUMN JOINTS FOR SEISMIC‐RESISTANT STRUCTURES: JOINT PERFORMANCE AND CASE STUDY ON MOMENT‐RESISTING FRAMES
Authors: Don Rafaela F. , Ciutina Adrian L. , Stratan Aurel , Vulcu Cristian M. 
Published: April 2023

AbstractThe current seismic design of steel and composite frames relies on lateral frame stiffness and on the controlled failure mechanism of dissipative members or connections. The implementation of the slim‐floor solution in practice results in several advantages. But due to the reduced height of the slim‐floor beam – generally considered to result in lower flexural stiffness – the current practice disregards the usage of moment‐resisting slim‐floor beam‐to‐column joints in seismic applications. However, a previous study of the authors has experimentally and numerically confirmed the possibility of expanding the application of composite beams by developing inelastic behaviour in slim‐floor beams. The test results allowed the definition of the slim‐floor beam's mechanical characteristics and the evaluation of the structure's seismic performance through nonlinear static and dynamic analyses. The usage of the slim‐floor system resulted in a vertical space gain ‐ due to its reduced height ‐ and demonstrated the solution's effectiveness when implemented in seismic‐resistant structures.
Cyclic Polymers: Controlled Synthesis, Properties and Perspectives
Authors: Gao Run‐Tan , Xu Lei , Li Shi‐Yi , Liu Na , Chen Zheng , Wu Zong‐Quan 
Published: April 2023

AbstractRecently, cyclic polymers have attracted increasing interest due to their unique topologies, properties, and functions compared to the linear analogues. This mini‐review focuses on the recent advances in the synthesis and applications of cyclic polymers. First, the main synthetic methods for cyclic polymers, namely ring closure and ring expansion methods, are presented and discussed, followed by a review on the exploration of the properties and applications of synthetic cyclic polymers. Finally, a critical assessment of the preliminary studies exploring the efficient synthesis and potential applications of cyclic polymers are presented, and the remaining challenges in the field as well as ideas for solving these challenges will be discussed.
A Blueprint for Transforming Indigos to Photoresponsive Molecular Tools
Authors: Huang Chung‐Yang (Dennis) , Hecht Stefan 
Published: April 2023

AbstractIndigo, one of the most ancient and abundant dyes in human history, has recently emerged as a potential functional motif due to its intriguing photochemical properties. This review aims to provide insights into both the preparation of these molecules and their utilization in molecular systems. First, the synthesis of the indigo core as well as available methods to derivatize indigo are described to outline synthetic strategies to build the desired molecular structures. Then, the photochemical behavior of indigos is discussed, with particular focus on E‐Z photoisomerization and photoinduced electron transfer. Connections between the molecular structures and their photochemical properties are highlighted and serve as guiding principles for designing indigos to be applied as photoresponsive tools.
Effects of diethylaluminum ethoxide pre‐reduction and chromium loading over bistriphenylsilyl chromate/silica for ethylene polymerization
Authors: Xue Xiaofeng , Yang Yang , Gao Yuli , Yi Jianjun , Liu Boping , Jin Yulong 
Published: April 2023

AbstractBistriphenylsilyl chromate (BC)/silica (S‐2 catalyst) is a commercially used high‐density polyethylene (HDPE) catalyst with great importance. In this work, the catalytic performance of this catalyst was tried to be improved by increasing the loading amount of Cr and pre‐reducing with diethylaluminum ethoxide (DEALE). It is found that, when the Cr loading amount was doubled, the productivity in gPE · g−1Cat became almost doubled as well, indicating the maintenance of overall efficiency for Cr centres. Meanwhile, pre‐reduction of BC/silica with a small amount of DEALE (the molar ratio of DEALE/Cr < 2.4) was adequate to promote its productivity greatly, while large dose of DEALE led to the activity decay fast, which might originate from the over‐reduction of the Cr centre, as well as pore blockages caused by the added DEALE. Moreover, it is found that both the increased Cr loading and DEALE pre‐reduction offered an alternative way to reduce the weight‐average molecular weight (MW) and molecular weight distribution (MWD) of the polyethylene products mainly by shaving the high MW shoulder.
Obesity in adult acute myeloid leukemia is not associated with inferior response or survival even when dose capping anthracyclines: An ECOG‐ACRIN analysis
Authors: Foran James M. , Sun Zhuoxin , Lai Catherine , Fernandez Hugo F. , Cripe Larry D. , Ketterling Rhett P. , Racevskis Janis , Luger Selina M. , Paietta Elisabeth , Lazarus Hillard M. , Zhang Yanming , Bennett John M. , Levine Ross L. , Rowe Jacob M. , Litzow Mark R. , Tallman Martin S. 
Published: April 2023

AbstractBackgroundObesity (body mass index [BMI] ≥30 kg/m2) is an important epidemiological risk factor for developing acute myeloid leukemia (AML). Therefore, the authors studied the association of obesity with clinical and genetic phenotype and its impact on outcome in adults with AML.MethodsThe authors analyzed BMI in 1088 adults who were receiving intensive remission induction and consolidation therapy in two prospective, randomized therapeutic clinical trials of the Eastern Cooperative Oncology Group‐American College of Radiology Imaging Network: E1900 (ClinicalTrials.gov identifier NCT00049517; patients younger than 60 years) and E3999 (ClinicalTrials.gov identifier NCT00046930; patients aged 60 years or older).ResultsObesity was prevalent at diagnosis (33%) and, compared with nonobesity, was associated with intermediate‐risk cytogenetics group (p = .008), poorer performance status (p = .01), and a trend toward older age (p = .06). Obesity was not associated with somatic mutations among a selected 18‐gene panel that was tested in a subset of younger patients. Obesity was not associated with clinical outcome (including complete remission, early death, or overall survival), and the authors did not identify any patient subgroup that had inferior outcomes based on BMI. Obese patients were significantly more likely to receive <90% of the intended daunorubicin dose despite protocol specification, particularly in the E1900 high‐dose (90 mg/m2) daunorubicin arm (p = .002); however, this did not correlate with inferior overall survival on multivariate analysis (hazard ratio, 1.39; 95% confidence interval, 0.90–2.13; p = .14).ConclusionsObesity is associated with unique clinical and disease‐related phenotypic features in AML and may influence physician treatment decisions regarding daunorubicin dosing. However, the current study demonstrates that obesity is not a factor in survival, and strict adherence to body surface area‐based dosing is not necessary because dose adjustments do not affect outcomes.
Meta‐analysis reveals drivers of restoration success for oysters and reef community
Authors: Smith Rachel S. , Castorani Max C. N. 
Published: April 2023

AbstractRestoration aims to reverse the global declines of foundation species, but it is unclear how project attributes, the physical setting, and antecedent conditions affect restoration success. In coastal seas worldwide, oyster reef restoration is increasing to counter historical habitat destruction and associated declines in fisheries production and biodiversity. Yet, restoration outcomes are highly variable and the factors that enhance oyster production and nekton abundance and diversity on restored reefs are unresolved. To quantify the drivers of oyster restoration success, we used meta‐analysis to synthesize data from 158 restored reefs paired with unstructured habitats along the United States Gulf and Atlantic coasts. The average recovery of oyster production was 65% greater in subtidal (vs. intertidal) zones, 173% greater in polyhaline (vs. mesohaline) environments and increased with tidal range, demonstrating that physical conditions can strongly influence the restoration success of foundation species. Additionally, restoration increased the relative abundance and richness of nektonic fishes and invertebrates over time as reefs aged (at least 8 years post‐construction). Thus, the restoration benefits for provisioning habitat and enhancing biodiversity accrue over time, highlighting that restoration projects need multiple years to maximize ecosystem functions. Furthermore, long‐term monitoring of restored and control sites is needed to assess restoration outcomes and associated drivers. Last, our work reveals data constraints for several potential drivers of restoration outcomes, including reef construction material, reef dimensions, harvest pressure and disease prevalence. More experimental and observational studies are needed to target these factors and measure them with consistent methods across studies. Our findings indicate that the assisted recovery of foundation species yields several enhancements to ecosystem services, but such benefits are mediated by time and environmental conditions.
Abrupt transitions in a southwest USA desert grassland related to the Pacific Decadal Oscillation
Authors: Christensen Erica M. , James Darren K. , Randall Robb M. , Bestelmeyer Brandon T. 
Published: April 2023

AbstractPrediction of abrupt ecosystem transitions resulting from climatic change will be an essential element of adaptation strategies in the coming decades. In the arid southwest USA, the collapse and recovery of long‐lived perennial grasses have important effects on ecosystem services, but the causes of these variations have been poorly understood. Here we use a quality‐controlled vegetation monitoring dataset initiated in 1915 to show that grass cover dynamics during the 20th century were closely correlated to the Pacific decadal oscillation (PDO) index. The relationship out‐performed models correlating grasses to yearly precipitation and drought indices, suggesting that ecosystem transitions attributed only to local disturbances were instead influenced by climate teleconnections. Shifts in PDO phase over time were associated with the persistent loss of core grass species and recovery of transient species, so recovery of grasses in aggregate concealed significant changes in species composition. However, the relationship between PDO and grass cover broke down after 1995; grass cover is consistently lower than PDO would predict. The decoupling of grass cover from the PDO suggests that a threshold had been crossed in which warming or land degradation overwhelmed the ability of any grass species to recover during favorable periods.
Natriuretic peptides: role in the diagnosis and management of heart failure: a scientific statement from the Heart Failure Association of the European Society of Cardiology, Heart Failure Society of America and Japanese Heart Failure Society
Authors: Tsutsui Hiroyuki , Albert Nancy M. , Coats Andrew J.S. , Anker Stefan D. , Bayes‐Genis Antoni , Butler Javed , Chioncel Ovidiu , Defilippi Christopher R. , Drazner Mark H. , Felker G. Michael , Filippatos Gerasimos , Fiuzat Mona , Ide Tomomi , Januzzi James L. , Kinugawa Koichiro , Kuwahara Koichiro , Matsue Yuya , Mentz Robert J. , Metra Marco , Pandey Ambarish , Rosano Giuseppe , Saito Yoshihiko , Sakata Yasushi , Sato Naoki , Seferovic Petar M. , Teerlink John , Yamamoto Kazuhiro , Yoshimura Michihiro 
Published: April 2023

ABSTRACTNatriuretic peptides, brain (B‐type) natriuretic peptide (BNP) and N‐terminal prohormone of brain natriuretic peptide (NT‐proBNP) are globally and most often used for the diagnosis of heart failure (HF). In addition, they can have an important complementary role in the risk stratification of its prognosis. Since the development of angiotensin receptor–neprilysin inhibitors (ARNIs), the use of natriuretic peptides as therapeutic agents has grown in importance. The present document is the result of the Trilateral Cooperation Project among the Heart Failure Association of the European Society of Cardiology, the Heart Failure Society of America and the Japanese Heart Failure Society. It represents an expert consensus that aims to provide a comprehensive, up‐to‐date perspective on natriuretic peptides in the diagnosis and management of HF, with a focus on the following main issues: (1) history and basic research: discovery, production and cardiovascular protection; (2) diagnostic and prognostic biomarkers: acute HF, chronic HF, inclusion/endpoint in clinical trials, and natriuretic peptide‐guided therapy; (3) therapeutic use: nesiritide (BNP), carperitide (ANP) and ARNIs; and (4) gaps in knowledge and future directions.
Eco‐friendly perovskite solar cells: From materials design to device processing and recycling
Authors: Wu Xin , Zhang Dong , Wang Xue , Jiang Xiaofen , Liu Baoze , Li Bo , Li Zhen , Gao Danpeng , Zhang Chunlei , Wang Yan , Zhu Zonglong 
Published: April 2023

AbstractWith the skyrocketed power conversion efficiency and enhanced lifetime of perovskite solar cells (PVSCs), the environmental issues from materials to device processing, operation, and recycling become critical for their commercialization. Developing eco‐friendly PVSCs via the exploration of lead‐free perovskite materials, non‐toxic solvents, and effective lead‐adsorbing materials are the key points to realizing eco‐friendly PVSCs, which have drawn significant attention in the past 3 years. This critical review presents a comprehensive overview of the recent progress of eco‐friendly PVSCs in a close loop, including eco‐friendly perovskite materials, eco‐friendly device processing, eco‐friendly device operation, and eco‐friendly perovskite recycling. The innovation of perovskite materials, criteria of green solvent selection, and design principles of lead adsorbents are thoroughly introduced, with their combination for the device processing and operation well explained. An outlook of further material innovation and device optimization is provided to offer instruction for the development of this research field.image
Cerebral blood flow patterns in preterm and term neonates assessed with pseudo‐continuous arterial spin labeling perfusion MRI
Authors: Piccirilli Eleonora , Chiarelli Antonio M. , Sestieri Carlo , Mascali Daniele , Calvo Garcia Darien , Primavera Adele , Salomone Rita , Wise Richard G. , Ferretti Antonio , Caulo Massimo 
Published: April 2023

AbstractIn preterm (PT) infants, regional cerebral blood flow (CBF) disturbances may predispose to abnormal brain maturation even without overt brain injury. Therefore, it would be informative to determine the spatial distribution of grey matter (GM) CBF in PT and full‐term (FT) newborns at term‐equivalent age (TEA) and to assess the relationship between the features of the CBF pattern and both prematurity and prematurity‐related brain lesions. In this prospective study, we obtained measures of CBF in 66 PT (51 without and 15 with prematurity‐related brain lesions) and 38 FT newborns through pseudo‐continuous arterial spin labeling (pCASL) MRI acquired at TEA. The pattern of GM CBF was characterized by combining an atlas‐based automated segmentation of structural MRI with spatial normalization and hierarchical clustering. The effects of gestational age (GA) at birth and brain injury on the CBF pattern were investigated. We identified 4 physiologically‐derived clusters of brain regions that were labeled Fronto‐Temporal, Parieto‐Occipital, Insular‐Deep GM (DGM) and Sensorimotor, from the least to the most perfused. We demonstrated that GM perfusion was associated with GA at birth in the Fronto‐Temporal and Sensorimotor clusters, positively and negatively, respectively. Moreover, the presence of periventricular leukomalacia was associated with significantly increased Fronto‐Temporal GM perfusion and decreased Insular‐DGM perfusion, while the presence of germinal matrix hemorrhage appeared to mildly decrease the Insular‐DGM perfusion. Prematurity and prematurity‐related brain injury heterogeneously affect brain perfusion. ASL MRI may, therefore, have strong potential as a noninvasive tool for the accurate stratification of individuals at risk of domain‐specific impairment.
Effect of magnesium sulfate treatment on mediators of endothelial dysfunction and electrolytes in mild and severe preeclampsia: A case‐control study
Authors: Fondjo Linda A. , Sarpong Davis , Owiredu William K. B. A. , Opoku Stephen , Adu‐Bonsaffoh Kwame , Teviu Emmanuel 
Published: April 2023

AbstractBackground and AimsMagnesium sulfate (MgSO4) treatment is widely used for the prevention of eclamptic seizures. However, its effect on mediators of endothelial dysfunction (ED) and electrolytes remains unclear. We evaluated the effects of MgSO4 treatment on mediators of ED and electrolytes.MethodsWe recruited 100 women comprising 50 severe, 50 mild preeclampsia (PE) as cases and 50 normotensive pregnant women as controls from the Sampa Government Hospital, Ghana. We estimated for adrenomedullin (AM), calcitonin gene‐related peptide (CGRP), soluble forms of intercellular adhesion molecule‐1 (sICAM‐1), Na+, K+, and Mg2+ before MgSO4 treatment, 24 h after MgSO4 treatment, and 48 h after delivery. p < 0.05 were considered significant for statistical analyses.ResultsLevels of AM, sICAM‐1, and Na+ decreased significantly at 24 h after MgSO4 treatment and 48 h after delivery among PE women compared to the AM levels before treatment (p < 0.0001). The levels of CGRP and Mg2+ increased significantly after 24 h of MgSO4 treatment and 48 h after delivery among PE compared to the AM levels before treatment (p < 0.0001). The changes in AM, sICAM‐1, CGRP, and Mg2+ at 24 h after treatment and 48 h after delivery were significantly higher in severe compared to mild PE (p < 0.0001). AM levels reduced significantly by 14.7% in mild and 42.7% in severe PE after MgSO₄ treatment (p < 0.05). sICAM‐1 levels reduced significantly by 20.9% in mild and 25% in severe PE after MgSO₄ treatment. After MgSO₄ treatment, there was significant increase of 42.1% and >100% in CGRP levels in mild and severe PE, respectively (p < 0.05). After MgSO₄ treatment, Mg²⁺ levels increased significantly by 67.0% and 63.8% in mild and severe PE, respectively (p < 0.05).ConclusionMgSO₄ treatment reduces AM, sICAM‐1, and sodium levels but improves magnesium and CGRP in severe than mild PE thus have more beneficial role in severe PE.
Interleukin‐6 levels can be used to estimate cardiovascular and all‐cause mortality risk in dialysis patients: A meta‐analysis and a systematic review
Authors: Chen Zeyu , Wang Yan 
Published: April 2023

AbstractBackgroundAlthough previous studies have explored the correlation of interleukin (IL)−6 with mortality risk in dialysis patients, the findings have been conflicting. Hence, this meta‐analysis aimed to comprehensively assess the use of IL‐6 measurement for estimating cardiovascular mortality and all‐cause mortality in dialysis patients.MethodsThe Embase, PubMed, Web of Science, and MEDLINE databases were searched to identify relevant studies. After screening out the eligible studies, the data were extracted.ResultsTwenty‐eight eligible studies with 8370 dialysis patients were included. Pooled analyses revealed that higher IL‐6 levels were related to increased cardiovascular mortality risk (hazard ratio [HR] = 1.55, 95% confidence interval [CI]: 1.20–1.90) and all‐cause mortality risk (HR = 1.11, 95% CI: 1.05–1.17) in dialysis patients. Further subgroup analyses suggested that higher IL‐6 levels were associated with elevated cardiovascular mortality in hemodialysis patients (HR = 1.59, 95% CI: 1.36–1.81) but not in peritoneal dialysis patients (HR = 1.56, 95% CI: 0.46–2.67). Moreover, sensitivity analyses indicated that the results were robust. Egger's test revealed potential publication bias among studies exploring the correlation of IL‐6 levels with cardiovascular mortality (p = .004) and all‐cause mortality (p < .001); however, publication bias was not observed when using Begg's test (both p > .05).ConclusionsThis meta‐analysis reveals that higher IL‐6 levels could indicate higher risks of cardiovascular mortality and all‐cause mortality in dialysis patients. These findings suggest that monitoring IL‐6 cytokine may help to enhance dialysis management and improve the general prognosis of patients.
Systemic inflammation influences the prognosis of patients with radically resected non‐small cell lung cancer and correlates with the immunosuppressive microenvironment
Authors: Wang Peiyu , Wang Shaodong , Sun Zewen , Li Hao , Zhao Yaxing , Li Yun , Yang Fan , Wang Jun , Chen Kezhong , Qiu Mantang , Li Xiao 
Published: April 2023

AbstractThe impact of host condition on prognosis of non‐small cell lung cancer (NSCLC) and the interaction between host and NSCLC remain unclear. This study investigated the association between systemic inflammation and prognosis and characteristics of radically resected NSCLC. This study consisted of a cohort study and an exploratory study of institutional prospective databases. All participants underwent video‐assisted thoracoscopic lobectomy as the primary treatment. Systemic inflammation was assessed before surgery using the advanced lung cancer inflammation index and the systemic inflammation response index. Next‐generation sequencing and multiplex immunofluorescence analysis were conducted to delineate tumor characteristics. In the cohort study including 1507 participants, high inflammation was associated with poor disease‐free survival and overall survival before and after propensity score matching and in multivariable analysis. Systemic inflammation showed good prognostic value for stage IA‐IB NSCLC, and the prognostic value diminished with upstaging of NSCLC. In the exploratory study including 217 adenocarcinomas, tumor microenvironment of high inflammation group showed a greater abundance of PDL1+ tumor cells and immune cells, which were independent from driver gene mutations and clinicopathological characteristics. Spatial analysis demonstrated a higher frequency of immune‐suppressed cellular neighborhood, increased avoidance between immune cells and PDL1‐ tumor cells and compromised immune killing and presentation in tumor microenvironment of high inflammation group. Systemic inflammation showed limited association with genomic mutations. Systemic inflammation may influence the prognosis of NSCLC at both the systematic level and the local immune response. The correlation between high inflammation and immunosuppressive microenvironment indicates a novel thread for anticancer treatment.
Genetic profile of borderline ovarian tumors in the Lebanese population by whole‐exome sequencing
Authors: Feghaly Iman , Kourie Hampig , Moubarak Malak , Chouery Eliane , Mehawej Cybel , Jalkh Nadine , Atallah David 
Published: April 2023

AbstractObjectiveTo assess the molecular profile of borderline ovarian tumors (BOT) in the Lebanese population by whole‐exome sequencing and to correlate the results with the patients' clinical profiles.MethodsWe included in this retrospective study 33 tumors belonging to 32 Lebanese women presenting with BOT, diagnosed at Hôtel Dieu de France. A total of 234 genes involved in different germinal and somatic types of cancer were analyzed using next‐generation sequencing.ResultsMolecular analysis of these tumors allowed us to detect mutations in genes involved in the mitogen‐activated protein kinase cascade in 57.58% of BOT and to identify variants affecting the DNA repair mechanism in 63.89% of samples. Furthermore, our initial analysis revealed an association between defects in DNA double‐strand break repair and the occurrence of mucinous BOT, in 75% of the cases.ConclusionThis study reports the molecular profiles of BOT in the Lebanese population and compares them to the literature. This is the first study associating the DNA repair pathway to BOT.