bluuebunny/crossref_metadata_2025_split huggingface dataset:
The flesh texture of teleost fish: Characteristics and interventional strategies
Authors: Wang Zhe , Qiao Fang , Zhang Wen‐Bing , Parisi Giuliana , Du Zhen‐Yu , Zhang Mei‐Ling 
Published: August 2023

AbstractWith the growing demand of consumers for high‐quality aquatic products, controlling the harvest quality of farmed fish is becoming increasingly important in aquaculture industry. The texture is a sensory property that covers a group of attributes, such as firmness, tenderness, chewiness, adhesiveness, resilience, etc., which greatly determine consumers' perception and satisfaction for flesh products. Regarding texture quality, extensive research has been conducted in recent decades based on its related theories, influencing factors, and intervention strategies. However, the information available is largely scattered and disjointed. Essentially, flesh texture is mainly determined by the collective contribution of three major muscle components: muscle fibres, intramuscular connective tissue, and intramuscular fat. Therefore, changing these components in living animals through nutritional and management factors has the potential to modulate texture quality. Here, we briefly introduced the features and development of the three muscle components mentioned above, particularly their potential contributions to texture quality of fish flesh. Exciting promises to manipulate flesh texture through dietary intervention, feed restriction, and exercise training were also discussed. To ensure their applications in large‐scale aquaculture facilities, specific considerations of these regimens should be incorporated in experimental design parameters, including the species and age of fish, research system, experiment duration, and exercise intensity. Finally, the existing challenges and limitations of fish texture studies were presented, along with some viewpoints about current work and future directions of this field.
Locally correct confidence intervals for a binomial proportion: A new criteria for an interval estimator
Authors: Garthwaite Paul H. , Moustafa Maha W. , Elfadaly Fadlalla G. 
Published: August 2023

AbstractWell‐recommended methods of forming “confidence intervals” for a binomial proportion give interval estimates that do not actually meet the definition of a confidence interval, in that their coverages are sometimes lower than the nominal confidence level. The methods are favoured because their intervals have a shorter average length than the Clopper–Pearson (gold‐standard) method, whose intervals really are confidence intervals. As the definition of a confidence interval is not being adhered to, another criterion for forming interval estimates for a binomial proportion is needed. In this paper, we suggest a new criterion for forming one‐sided intervals and equal‐tail two‐sided intervals. Methods which meet the criterion are said to yieldlocally correct confidence intervals. We propose a method that yields such intervals and prove that its intervals have a shorter average length than those of any other method that meets the criterion. Compared with the Clopper–Pearson method, the proposed method gives intervals with an appreciably smaller average length. For confidence levels of practical interest, the mid‐ method also satisfies the new criterion and has its own optimality property. It gives locally correct confidence intervals that are only slightly wider than those of the new method.
Gertrud Kuznitzky and Edith Stein on (non)conceptual experience
Authors: Neumann Daniel 
Published: August 2023

AbstractThis article considers a largely overlooked phenomenological account of nonconceptual experience that turns on experience having a sense that is unique to intuition, and which can be invoked to explain how we come to view what we experience in objective terms without referring to ready‐made concepts. The two early phenomenologists Edith Stein and Gertrud Kuznitzky are discussed as having elaborated two distinct, yet related, versions of this intuitive sense. My discussion identifies two common assumptions of both philosophers: firstly, the idea that the objective character of intuition hinges on the structure of apprehension, which is found by investigating the regularities of the appearance of objects; secondly, the objective character of intuition presupposes a metaphysical notion of things having a sense in themselves. Importantly, both philosophers do not take this “sense in itself” to be a direct part of the contents of experience, showing objectivity to arise out of intuition instead.
Evaluation of Dengue, Zika virus, and Chikungunya virus transmission by blood components in recipients of haematopoietic stem cell transplantation
Authors: de Oliveira Fernando Nivaldo , Ferreira Suzete Cleusa , Nishiya Anna Shoko , Mendrone‐Junior Alfredo , Batista Marjorie Vieira , Rocha Vanderson , Costa Silvia Figueiredo 
Published: August 2023

AbstractBackgroundBrazil has a high prevalence of arboviruses, especially Dengue (DENV), Zika (ZKV), and Chikungunya (CHKV).ObjectivesTo study the risk of DENV, ZKV, and CHKV transmission by blood components in the haematopoietic stem cell transplantation (HSCT) population.MethodsProspective cohort of HSCT recipients and donors performed at the Hospital das Clinicas da FMUSP, São Paulo‐Brazil. Patients were evaluated by serology and RT‐PCR for DENV, ZKV, and CHKV pre‐transplantation and once a week until neutrophil grafting. In positive cases (positive RT‐PCR and/or serology conversion), an investigation was carried out on the blood components that the patient received to evaluate the possibility of it being transfusion transmitted.ResultsA total of 93 patients were included during the study period. The mean age was 52 years with a predominance of males (56.9%). We considered five (5.3%) DENV cases positive by seroconversion in our study. One patient had IgM seroconversion and the other four presented IgG seroconversion to DENV. In the investigation of the blood components, 145 individual samples were analysed. None of the investigated blood components showed a positive RT‐PCR.ConclusionWe observed a low prevalence of DENV, ZKV, and CHKV in HSCT donors and recipients by serology and RT‐PCR, and no case of blood transfusion transmission by RT‐PCR.
Resistance wheel running improves contractile strength, but not metabolic capacity, in a murine model of volumetric muscle loss injury
Authors: Schifino Albino G. , Raymond‐Pope Christiana J. , Heo Junwon , McFaline‐Figueroa Jennifer , Call Jarrod A. , Greising Sarah M. 
Published: August 2023

AbstractThe primary objective of this study was to determine if low‐ or high‐resistance voluntary wheel running leads to functional improvements in muscle strength (i.e., isometric and isokinetic torque) and metabolic function (i.e., permeabilized fibre bundle mitochondrial respiration) after a volumetric muscle loss (VML) injury. C57BL/6J mice were randomized into one of four experimental groups at age 12 weeks: uninjured control, VML untreated (VML), low‐resistance wheel running (VML‐LR) and high‐resistance wheel running (VML‐HR). All mice, excluding the uninjured, were subject to a unilateral VML injury to the plantar flexor muscles and wheel running began 3 days post‐VML. At 8 weeks post‐VML, peak isometric torque was greater in uninjured compared to all VML‐injured groups, but both VML‐LR and VML‐HR had greater (∼32%) peak isometric torque compared to VML. All VML‐injured groups had less isokinetic torque compared to uninjured, and there was no statistical difference among VML, VML‐LR and VML‐HR. No differences in cumulative running distance were observed between VML‐LR and VML‐HR groups. Because adaptations in VML‐HR peak isometric torque were attributed to greater gastrocnemius muscle mass, atrophy‐ and hypertrophy‐related protein content and post‐translational modifications were explored via immunoblot; however, results were inconclusive. Permeabilized fibre bundle mitochondrial oxygen consumption was 22% greater in uninjured compared to VML, but there was no statistical difference among VML, VML‐LR and VML‐HR. Furthermore, neither wheel running group demonstrated a change in the relative protein content of the mitochondrial biogenesis transcription factor, peroxisome proliferator‐activated receptor γ coactivator 1‐α (PGC‐1α). These results indicate that resistance wheel running alone only has modest benefits in the VML‐injured muscle.
Los umbrales del humanismo. Las polaridades de la cultura y sus relatos
Authors: Castellanos S.J. Luis Alfonso 
Published: August 2023

El artículo “Los umbrales del humanismo. Las polaridades de la cultura y sus relatos” pretende realizar una introspección del humanismo como un proyecto narrativo y como una configuración afectiva que requiere de prácticas y artefactos culturales para conformar sujetos y sociedades.
Desde una mirada transdisciplinar y desde variadas perspectivas se problematiza la noción de humanismo como una configuración afectiva que se teje desde dos experiencias fundamentales: lo sublime y lo abyecto. Extremos que en sus manifestaciones se hacen los ejes de elaboración de cualquier sentido de “lo humano” y que sustentan los diversos relatos y artefactos que en la cultura de Occidente se han identificado con el humanismo. Narrativas humanísticas que además se consolidan en variados productos estéticos y que en sus diversas propuestas desean ser sapienciales. Sabiduría práctica más que teorías o elaboraciones éticas o filosóficas; presupuestos primeros de cualquier grupo humano que en su función de base establecen modos de proceder individuales y prácticas sociales.
Governing Equation Identification of Nonlinear Single Degree-of-Freedom Oscillators With Coulomb Friction Using Explicit Stick and Slip Temporal Constraints
Authors: Mahajan Saurabh , Cicirello Alice 
Published: August 2023

Abstract
The friction force at joints of engineering structures is usually unknown and not directly identifiable. This contribution explores a procedure for obtaining the governing equation of motion and correctly identifying the unknown Coulomb friction force of a mass-spring-dashpot system. In particular, a single degree-of-freedom system is investigated both numerically and experimentally. The proposed procedure extends the state-of-the-art data-driven sparse identification of nonlinear dynamics (SINDy) algorithm by developing a methodology that explicitly imposes constraints encoding knowledge of the nonsmooth dynamics experienced during stick-slip phenomena. The proposed algorithm consists of three steps: (i) data segregation of mass-motion from mass-sticking during stick-slip response; (ii) application of SINDy on the mass-motion dataset to obtain the functional form of the governing equation; and (iii) applying sticking and slipping conditions to identify the unknown system parameters. It is shown that the proposed approach yields an improved estimate of the uncertain system parameters such as stiffness, viscous damping, and magnitude of friction force (all mass normalized) for various signal-to-noise ratios compared to SINDy.
Circle of Willis integrity in acute middle cerebral artery occlusion: does the posterior communicating artery matter?
Authors: Sadeh-Gonik Udi , Budylev Anatoly , Krivitzky David , Molad Jeremy , Halevi Hen , Jonas-Kimchi Tali , Yashar Hila , Ben Assayag Einor , Seyman Estelle 
Published: August 2023

BackgroundCollateral circulation is an important determinant of outcome in people with acute ischemic stroke due to large vessel occlusion (LVO).ObjectiveTo explore the impact of the circle of Willis (CW) anatomical characteristics ipsilateral to the occlusion site, particularly the posterior communicating artery (PComA) and the A1-portion of the anterior cerebral artery (A1-ACA), on stroke outcomes in a cohort of patients with LVO and middle cerebral artery (MCA) occlusion, undergoing endovascular thrombectomy (EVT).MethodsThis is a retrospective cohort study performed in a comprehensive tertiary stroke center. The study population consisted of consecutive patients with LVO with proximal MCA occlusion (M1) between June 2016 and April 2021, undergoing EVT. Demographic, clinical, and imaging information was extracted from patient files. Patency and diameters of ipsilateral A1-ACA and PComA were manually measured on admission CT angiography images in the core laboratory.ResultsOne hundred and five patients with LVO comprised the study cohort, mean age 72.3 years, 43.8% were male, mean National Institutes of Health Stroke Scale score at admission 15.2. The cohort was grouped according to CW vessel characteristics. On univariate analysis, a well-developed PComA was associated with lower rates of hemorrhagic transformation (1.8% vs 14.3%, P=0.01) and a trend towards lower mortality rates (8.9% vs 20.4%, P=0.08).On multivariable regression analysis a well-developed PComA emerged as an independent predictor for survival (aOR=0.09, 95% CI 0.01 to 0.4 for survival at discharge, P=0.009, aOR=0.22, 95% CI 0.05 to 0.8 for survival at 90 days, P=0.02).ConclusionsIn a cohort of patients with LVO due to M1 occlusion undergoing EVT, a well-developed PComA was associated with significantly lower hemorrhagic transformation rates, a trend towards better functional outcomes, and independently predicted survival. Larger studies are needed to understand the differential effect of CW collateral conduits on stroke outcome and evaluate the practicality of incorporating such factors in the clinical decision-making process prior to EVT.
MR microscopy to assess clot composition following mechanical thrombectomy predicts recanalization and clinical outcome
Authors: Karimian-Jazi Kianush , Vollherbst Dominik F , Schwarz Daniel , Fischer Manuel , Schregel Katharina , Bauer Gregor , Kocharyan Anna , Sturm Volker , Neuberger Ulf , Jesser Jessica , Herweh Christian , Ulfert Christian , Hilgenfeld Tim , Seker Fatih , Preisner Fabian , Schmitt Niclas , Charlet Tobias , Hamelmann Stefan , Sahm Felix , Heiland Sabine , Wick Wolfgang , Ringleb Peter A , Schirmer Lucas , Bendszus Martin , Möhlenbruch Markus A , Breckwoldt Michael O 
Published: August 2023

BackgroundMechanical thrombectomy (MT) is the standard of care for patients with a stroke and large vessel occlusion. Clot composition is not routinely assessed in clinical practice as no specific diagnostic value is attributed to it, and MT is performed in a standardized ‘non-personalized’ approach. Whether different clot compositions are associated with intrinsic likelihoods of recanalization success or treatment outcome is unknown.MethodsWe performed a prospective, non-randomized, single-center study and analyzed the clot composition in 60 consecutive patients with ischemic stroke undergoing MT. Clots were assessed by ex vivo multiparametric MRI at 9.4 T (MR microscopy), cone beam CT, and histopathology. Clot imaging was correlated with preinterventional CT and clinical data.ResultsMR microscopy showed red blood cell (RBC)-rich (21.7%), platelet-rich (white,38.3%) or mixed clots (40.0%) as distinct morphological entities, and MR microscopy had high accuracy of 95.4% to differentiate clots. Clot composition could be further stratified on preinterventional non-contrast head CT by quantification of the hyperdense artery sign. During MT, white clots required more passes to achieve final recanalization and were not amenable to contact aspiration compared with mixed and RBC-rich clots (maneuvers: 4.7 vs 3.1 and 1.2 passes, P<0.05 and P<0.001, respectively), whereas RBC-rich clots showed higher probability of first pass recanalization (76.9%) compared with white clots (17.4%). White clots were associated with poorer clinical outcome at discharge and 90 days after MT.ConclusionOur study introduces MR microscopy to show that the hyperdense artery sign or MR relaxometry could guide interventional strategy. This could enable a personalized treatment approach to improve outcome of patients undergoing MT.
The Ratio of Key Metabolic Transcripts Is a Predictive Biomarker of Breast Cancer Metastasis to the Lung
Authors: Mathur Deepti , Liao Chen , Lin Wendy , La Ferlita Alessandro , Alaimo Salvatore , Taylor Samuel , Zhong Yi , Iacobuzio-Donahue Christine , Ferro Alfredo , Xavier Joao B. 
Published: August 2023

Abstract

Understanding the rewired metabolism underlying organ-specific metastasis in breast cancer could help identify strategies to improve the treatment and prevention of metastatic disease. Here, we used a systems biology approach to compare metabolic fluxes used by parental breast cancer cells and their brain- and lung-homing derivatives. Divergent lineages had distinct, heritable metabolic fluxes. Lung-homing cells maintained high glycolytic flux despite low levels of glycolytic intermediates, constitutively activating a pathway sink into lactate. This strong Warburg effect was associated with a high ratio of lactate dehydrogenase (LDH) to pyruvate dehydrogenase (PDH) expression, which correlated with lung metastasis in patients with breast cancer. Although feature classification models trained on clinical characteristics alone were unable to predict tropism, the LDH/PDH ratio was a significant predictor of metastasis to the lung but not to other organs, independent of other transcriptomic signatures. High lactate efflux was also a trait in lung-homing metastatic pancreatic cancer cells, suggesting that lactate production may be a convergent phenotype in lung metastasis. Together, these analyses highlight the essential role that metabolism plays in organ-specific cancer metastasis and identify a putative biomarker for predicting lung metastasis in patients with breast cancer.

Significance:
Lung-homing metastatic breast cancer cells express an elevated ratio of lactate dehydrogenase to pyruvate dehydrogenase, indicating that ratios of specific metabolic gene transcripts have potential as metabolic biomarkers for predicting organ-specific metastasis.
Androgen Receptor Variants Confer Castration Resistance in Prostate Cancer by Counteracting Antiandrogen-Induced Ferroptosis
Authors: Sun Rui , Yan Binyuan , Li Hao , Ding Donglin , Wang Liguo , Pang Jun , Ye Dingwei , Huang Haojie 
Published: August 2023

Abstract

Androgen receptor (AR) inhibition by androgen deprivation and/or antiandrogen administration is the mainstay therapy for advanced prostate cancer. However, most prostate cancers ultimately become resistant to these therapies, indicating the importance of identifying mechanisms driving resistance to improve patient outcomes. Here we demonstrated that acute treatment with the antiandrogen enzalutamide (ENZ) decreased glutathione (GSH) production, increased lipid peroxidation, and induced ferroptosis in prostate cancer cells. Consistently, meta-analysis of transcriptomic data linked the androgen-AR axis to metabolism-related biological processes, including lipid metabolism. The cystine transporter gene SLC7A11 was a key AR target, and full-length AR (AR-FL) transactivated SLC7A11 transcription by directly occupying the SLC7A11 promoter and putative enhancer regions. AR variants (AR-V) preferentially bound the SLC7A11 enhancer and upregulated SLC7A11 expression, thereby conferring resistance to ferroptosis induced by ENZ treatment. However, this effect was abolished following downregulation of AR-Vs using the dual CBP/p300 and BET inhibitor NEO2734. These findings reveal ferroptosis induction as an anticancer mechanism of antiandrogens and SLC7A11 as a direct target gene of AR-FL and AR-Vs. AR-V-mediated SLC7A11 expression represents a mechanism coupling ferroptosis resistance to prostate cancer progression.

Significance:
Upregulation of SLC7A11 can be induced by androgen receptor variants to inhibit antiandrogen-induced prostate cancer cell ferroptosis and to drive castration resistance in prostate cancer.
Dificultades y vulnerabilidades de la niñez migrante durante la pandemia por covid-19
Authors: Cárdenas María Elvira , Grau-Rengifo María Olaya , Alamo Anich Nicolle , Bernales Silva Margarita , López Contreras Eleonora , Donoso Vargas Bárbara , Veas Flores Alicia , Grau-Rengifo María Florencia 
Published: August 2023

(analítico)
Considerando la necesidad de escuchar a niños y niñas migrantes, examinamos desde su mirada las dificultades y vulnerabilidades a las que ellos, ellas y sus familias se enfrentaron durante las cuarentenas, en la pandemia por covid-19 en Chile; durante ellas mantuvieron clases a distancia, en línea o por guías de trabajo. Hicimos entrevistas semiestructuradas con guión temático —utilizando técnicas gráficas— a 37 niños y niñas migrantes de Latinoamérica, y realizamos análisis de contenido. Evidenciamos que las familias migrantes, des-de la mirada de los niños y niñas, se han visto expuestas a dificultades y preocupaciones (dada la distancia física entre familiares), vulnerabilidades económicas, falta de redes familiares y dificultades en la organización del trabajo productivo y reproductivo; en cada caso desde los puntos de vista objetivo y subjetivo.
Palabras clave: Migración; niñez; familia; pandemia; Chile; vulnerabilidad.
Nominal Case in Christian Arabic Translations of the Gospels (9th-15th Centuries CE)
Authors: Stokes Phillip W. 
Published: August 2023

Abstract
Middle Arabic is conventionally defined as existing on a spectrum between colloquial Arabic on the low end and Classical Arabic on the high end. Differences between Middle Arabic and Classical Arabic that are not attested in a modern dialect are typically treated, historically at least, as due to pseudo-correction. This is especially true of non-Classical manifestations of nominal case. In this paper, I tag all instances of alif al-tanwīn – which in Qurʾānic and Classical Arabic marks the accusative on triptotic nouns that do not end in tāʾ marbūṭa – from representative portions of the manuscripts, both vocalized and unvocalized, of 15 Christian translations of the gospels into Arabic dating from the 9th to 15th centuries CE. The data demonstrate, contrary to previous descriptions, that the majority of case inflection is written in line with Classical Arabic norms. Further, the syntactic contexts in which non-Classical case markings occur follow regular patterns, which recur with remarkable consistency across time and manuscript. Instead of originating in pseudo-corrections, I propose the differences from Classical Arabic originated in attempts by Christian scribes to represent a variety of Arabic in which a vowel merger before tanwīn resulting in a single morpheme erased the vocalic distinctions between case vowels. These syntactic contexts include nominative, genitive, and accusative ones. Since Christian Arabic differed from the varieties for which the Arabic script and subsequent vocalizations were developed to write, scribes originally varied in the degree to which they adhered to the writing conventions, with some closely adhering and others taking greater liberties in order to represent the underlying variety with greater nuance. Over time, this led to several scribal traditions for writing tanwīn in Christian manuscripts, each of which is attested among the vocalized manuscripts included in this study and discussed in detail.