bluuebunny/crossref_metadata_2025_split huggingface dataset:
The comprehensive analysis of m6A-associated anoikis genes in low-grade gliomas
Authors: Zheng Hui , Zhao Yutong , Zhou Hai , Tang Yuguang , Xie Zongyi 
Published: June 2023

Abstract
Background
The relationship between N6-methyladenosine (m6A) regulators and anoikis and their effects on low-grade glioma (LGG) are not clear yet.
Methods
The TCGA-LGG cohort, mRNAseq 325 dataset and GSE16011 validation set were separately gained via The Cancer Genome Atlas (TCGA), Chinese Glioma Genome Altas (CGGA) and Gene Expression Omnibus (GEO) databases. 27 m6A-related genes (m6A-RGs) and 508 anoikis-related genes (ANRGs) were extracted from published articles, individually. First, differentially expressed genes (DEGs) between LGG and Normal samples were sifted out by differential expression analysis. DEGs were respectively intersected with m6A-RGs and ANRGs to acquire differentially expressed m6A-RGs (DE-m6A-RGs) and differentially expressed ANRGs (DE-ANRGs). Correlation analysis of DE-m6A-RGs and DE-ANRGs was performed to obtain DE-m6A-ANRGs. Next, univariate Cox and least absolute shrinkage and selection operator (LASSO) were performed on DE-m6A-ANRGs to sift out risk model genes, and risk score was gained according to them, then gene set enrichment analysis (GSEA) was implemented based on risk model genes. After that, we constructed an independent prognostic model, and performed immune infiltration analysis and drug sensitivity analysis. Finally, an mRNA-miRNA-lncRNA regulatory network was constructed.
Results
There were 6901 DEGs between LGG and Normal samples. six DE-m6A-RGs and 214 DE-ANRGs were gained through intersecting DEGs with m6A-RGs and ANRGs, respectively. 149 DE-m6A-ANRGs were derived after correlation analysis. 4 genes namely ANXA5, KIF18A, BRCA1 and HOXA10 composed the risk model, and they involved in apoptosis, fatty acid metabolism and glycolysis, etc.. The age and risk score were finally sifted out to construct independent prognostic model. Activated CD4 T cell, gamma delta T cell and natural killer T cell had the largest positive correlation with risk model genes, while activated B cell was significantly negatively correlated with KIF18A and BRCA1. AT.9283, EXEL.2280, Gilteritinib and Pracinostat had the largest correlation (Absolute value) with risk score. 4 risk model genes (mRNAs)_, 12 miRNAs and 21 lncRNAs formed mRNA-miRNA-lncRNA network, containing HOXA10-hsa-miR-129-5p-LINC00689, KIF18A-hsa-miR- 221-3p-DANCR, etc..
Conclusion
Through bioinformatics, we constructed a prognostic model of m6A-associated anoikis genes in LGG, providing new ideas for research related to prognosis and treatment of LGG.
Methodological Issues: Gender related Indices
Authors: Chakrabartty Satyendra 
Published: June 2023

Abstract
Gender related Index (GRI) is a singled valued function combining selected dimensions containing different number of components. Measurement of multidimensional GRIs involves measurement issues for meaningful aggregations and comparisons over time and space.
The paper proposes gender inequality through multiplicative aggregation (\({GRI}_{GM}\)) and gender similarity index (GSI) by cosine similarity, avoiding scaling, finding weights and satisfying desired properties. Inverse relationship derived between \({GRI}_{GM}\) and GSI.
Each proposed index reduces level of substitutability, effect of outliers. Each facilitates aggregation of country-wise scores to find world average, statistical testing of equality of mean of two countries or mean of a country at two time-periods using Y-scores obtained from each measure by linear transformations where Y\(\in\)[0, 100] and Y \(\sim\) N (\(\mu , {\sigma }^{2})\). Each index can be used for ranking and classification of countries. GSI can indicate current distance of a country from the goal of zero gender inequality. \({GRI}_{GM}\) can assess progress/decline in successive periods for women and separately for men. \({GRI}_{GM}\)is preferred for satisfaction of time-reversal test, easy identification of critical areas and contribution of the components or dimensions to the index.
Empirical verification of the proposed indices and their properties including robustness could be taken as future studies
JEL classification: D63, J16, O15
Effect of In-Utero Exposure to Air Pollution on Adulthood Hospitalizations
Authors: Bassols Nicolau Martin , Johnston David , Shields Michael , de New Sonja 
Published: June 2023

Abstract
Empirical analyses have demonstrated that individuals exposed to severe air pollution in-utero have worse health outcomes during childhood. However, there is little evidence on the long-term health impacts of air pollution exposure. The objective of this paper is to estimate the effect of in-utero exposure to the Great London Smog of 1952 (GLS) on five health outcomes identified through a scoping review to be those most likely affected: respiratory, circulatory, neoplasms, mental health, and nervous system conditions. We use the GLS, an extreme air pollution event in December 1952, as a quasi-natural experiment to estimate the effect of exposure to air pollution in-utero on adulthood health. Data from the UK Biobank is analyzed for a cohort of participants born from December 1952 to July 1956. Differences in health outcomes between adults exposed and not exposed to the GLS due to their birth dates, born inside and outside London, were explored. Our primary focus is hospitalization events between 1997 and 2020 (corresponding to ages 40 to 69), as recorded in linked administrative data from the National Health Service (NHS). Specifically, the five primary outcomes are binary variables indicating that the individual had at least one hospitalization where the main cause of hospitalization is related to respiratory, circulatory, neoplasms, mental health, or nervous system conditions. The analytical sample comprised 36,281 individuals. A positive effect on adulthood hospitalizations due to respiratory conditions was observed. If exposed to the GLS in-utero, the probability of at least one respiratory health-related hospitalization between 1997 to 2020 increased by 2.58 percentage points (95% CI 0.08, 4.30, p=0.03), a 23% increase relative to the sample mean. Small effects were found for all other outcomes, suggesting that these conditions were not affected by the GLS. We do not find heterogeneous effects by sex or childhood socioeconomic status.
Receptive Field Enhancement and Attention Feature Fusion Network for Underwater Object Detection
Authors: Xu Huipu , He Zegang , Cheng Shuo 
Published: June 2023

Abstract

Underwater environments have characteristics such as unclear imaging and complex backgrounds, which lead to poor performance when applying mainstream object detection models directly. To improve the accuracy of underwater object detection, we propose a novel object detection model RF-YOLO, which uses Receptive Field Enhancement Module(RFAM)in the backbone network to finish receptive field enhancement and extract more effective features. We design Free-channel iterative Attention Feature Fusion༈FAFF༉ module to reconstruct the neck network and fuse different scales of feature layers to achieve cross-channel attention feature fusion. We use SIoU as the loss function of the model, which makes the model converge to the optimal direction of training through angle cost, distance cost, shape cost, and IoU cost. The network parameters increase after adding modules, and the model is not easy to converge to the optimal state, so we propose a new training method, which effectively mines the performance of the detection network. Experiments show that the proposed RF-YOLO achieves mAP of 87.56% and 86.39% on URPC2019 and URPC2020 respectively. Through comparative experiments and ablation experiments, it was verified that the proposed network model has higher detection accuracy in complex underwater environments.
Inverse nodal problems for perturbed spherical schrödinger operators
Authors: Liu Yu , Shi Guoliang , Yan Jun 
Published: June 2023

Abstract
The inverse nodal problem for perturbed spherical Schrödinger operator defined on (0, 1) is studied. We prove that the potential on the whole interval can be uniquely determined in terms of a twin dense nodal subset known on the interior subinterval (a,1), a∈(0,1). Especially, when a∈(1/2,1), we need additional spectral information, which is associated with the derivatives of eigenfunctions at some known nodal points.
Optimizing LiNi0.8Co0.1Mn0.1O2 cathode material via modification by polyphosphoric acid on the surface
Authors: Shao Yifeng , Xu Shoudong , Lu Zhonghua , Chen Liang , Chen Jiaqi , Yi Qun , Zhang Ding 
Published: June 2023

Abstract
Nickel-rich layered oxide LiNi0.8Co0.1Mn0.1O2 (NCM) cathode material is widely noticed because of its high energy density and low cost. The widely explored NCM often shows inferior surface stability and tends to generate residual lithium carbonate (Li2CO3) on the surface, deteriorating the cyclic stability. The work attempts an efficient procedure by adopting polyphosphoric acid (PPA) to generate lithium phosphate (Li3PO4) as the surface coating layer, increasing the capacity retention ratio, which is 84.2% and 72.5% for the modified cathode material NCM@LP-3 (with the addition of 3% PPA) for 300 cycles and 500 cycles at 1 C. Electrochemical impedance spectra results show that the contact resistance and charge transfer resistance of NCM@LP-3 are significantly less than that of NCM after 500 cycles. SEM further demonstrates that microcracks of NCM@LP-3 are less severe than NCM. This work provides an effective method for surface modification.
Endoscopic Endonasal Approach to the Orbit: A Cadaveric Study and Case Series Emphasizing the Benefits of Ipsilateral Mononostril Technique
Authors: Gulsuna Beste , Truong Huy Quang , Aksoğan Yiğit , Nehir Ali , Sahin Muammer Melih , Celtikci Emrah 
Published: June 2023

Abstract
Background
Lesions located in the orbit are challenging to manage due to the enclosed space they occupy and their close proximity to critical anatomical structures. The challenge has been to develop a surgical approach that achieves the goal of obtaining complete tumor removal while preserving functional anatomy. Our aim is to understand the surgical anatomy of the orbital apex and inferomedial orbital structures via the ipsilateral endoscopic endonasal approach (EEA) and its feasibility in clinical practice.
Methods
Five fresh human head specimens were prepared for dissection. Anatomic dissections were performed by using rigid endoscopes, attached to a high-definition camera and a digital recording system. To achieve a meticulous understanding of the anatomy, an EEA to the sellar region was performed by involving a wide bilateral sphenoidotomy, posterior and anterior ethmoidectomy and orbital dissection in a stepwise manner. A retrospective evaluation was carried out with patients who underwent surgery through the ipsilateral mononostril EEA between August 2018 and August 2022.
Results
The results of endoscopic endonasal cadaveric dissections showed that the medial, inferomedial, and apex portions of the orbit can be accessed through the ipsilateral EEA. Eighteen patients who underwent EEA surgery for various pathologies, 72% of the lesions were intraconal. The patients were between the ages of 17 and 54 (mean 34,1 ± 8,6). The left orbit was affected more commonly (11 left, 7 right) and the most common pathology was intraorbital cavernous hemangioma (13). The average postoperative follow up duration was 22.2 months (range 6 months – 50 months).
Conclusion
Our study highlights the potential benefits of using a purely ipsilateral mononostril EEA for orbital surgery, particularly for accessing medial and inferomedial orbital lesions, and utilizing the knowledge gained from cadaveric dissection experience. This technique has the potential to reduce morbidity and improve outcomes, especially when used in conjunction with careful patient selection, preoperative planning, and advanced endoscopic skills. Given the limited literature on the subject, we believe that our study, which presents a large case series of orbital pathology operated with the ipsilateral mononostril EEA method, will provide valuable contributions to the literature and guide surgeons considering this approach.
Predictive Modeling of Occupational Safety Risks Associated with Railway Workers Using Hybrid Fuzzy Modeling Approach
Authors: Korenevskiy Nikolay , Al-kasasbeh Riad , Rodionova Sofia , Shaqdan Ashraf , Al-Habahbeh Osama , Khrisat Mohammad , Filist Seregy , Alshamasin Mahdi , Ilyash Maksim 
Published: June 2023

Abstract
Diagnosis, reporting and proper analysis of occupational diseases among railway workers and crew remain unsatisfactory so far. This paper focus on utilizing the concepts of human factors and ergonomics (HFE) for improving the quality of care provided to railway workers, in particular, railway transportation crews. The high level of morbidity in this category of workers makes it important to search for new methods and innovative approach for improve the quality of decision-making related to the risks of the development of occupational diseases in railway crews. The paper aims to develop a method for the prediction and diagnoses of occupational diseases of railway crew workers, this will allow gathering decision rules necessary for improving the quality of medical care provided to crew and preventive strategies based on best practices. The decision rules obtained in the work take into account various risk factors associated with the design and working conditions in the cab of a locomotive in combination with other factors that may increase the risk of the occurrence and development of occupational diseases for workers of locomotive crews that is caused by poor or inappropriate working conditions. The authors investigated the various risks causing occupational diseases, and extrapolate the relationships revealed to railway workers in order to forecast high risk of occupational diseases among railway crew.
Relative efficacies of EGFR-TKIs and immune checkpoint inhibitors for treatment of recurrent non-small cell lung cancer after surgery
Authors: Motono Nozomu , Mizoguchi Takaki , Ishikawa Masahito , Iwai Shun , Iijima Yoshihito , Uramoto Hidetaka 
Published: June 2023

Abstract
Background
The relative efficacies of epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) and immune checkpoint inhibitors (ICIs) for the treatment of recurrent non-small cell lung cancer (NSCLC) after surgery remain unclear.
Methods
Among 801 patients with NSCLC who underwent pulmonary resection at Kanazawa Medical University between 2017 and 2021, 64 patients had recurrence. We retrospectively compared the efficacies of EGFR-TKIs and ICIs in these patients with recurrent NSCLC who underwent pulmonary resection.
Results
The 3-year overall survival rates after recurrence were 79.3% in patients who received EGFR-TKIs, 69.5% in patients who received ICIs, and 43.7% in patients who received cytotoxic agents. There was no significant difference in overall survival between patients treated with EGFR-TKIs and ICIs (p = 0.14) or between patients treated with ICIs and cytotoxic agents (p = 0.23), but overall survival was significantly higher in patients treated with EGFR-TKIs compared with cytotoxic agents (p < 0.01) The probabilities of a 2-year response were 88.5%, 61.6%, and 25.9% in patients treated with EGFR-TKIs, ICIs, and cytotoxic agents, respectively. There was no significant difference in response periods between patients treated with EGFR-TKIs and ICIs (p = 0.18), but the response period was significantly better in patients treated with EGFR-TKIs (p < 0.01) or ICIs (p = 0.03) compared with cytotoxic agents. Percent-predicted vital capacity (p = 0.03) and epidermal growth factor receptor gene mutation (p < 0.01) were significant factors affecting the overall response to chemotherapy in multivariate analysis.
Conclusion
EGFR-TKIs and ICIs are effective for treating recurrent NSCLC after surgery. Although adjuvant chemotherapy for completely resected pathological stage II to IIIA NSCLC, atezolizumab or osimertinib, has also been recently approved as adjuvant chemotherapy, there is a risk that patients who relapse after adjuvant chemotherapy will have less choice.
Emergence of Carbapenem Resistant Enterobacteriaceae co-harboring bla OXA-78 and bla OXA-58 from India
Authors: Das Bhaskar Jyoti , Singha K. Melson , Wangkheimayum Jayalaxmi , Chanda Debadatta Dhar , Bhattacharjee Amitabha 
Published: June 2023

Abstract
Background Carbapenem Resistant Enterobacteriaceae (CRE) has been categorized as pathogens of critical priority by both CDC and WHO as they pose significant threat to global public health. Carbapenemase production considered as the principal resistance mechanism against carbapenems and with the recent surge and expansion of carbapenemases and its variants among clinically significant bacteria in India, the present study reports expansion blaOXA-78 and blaOXA-58 of in CRE of clinical origin.Methods Bacterial isolates were collected from a tertiary referral hospital and identified through VITEK® 2 Compact automated System (Biomerieux, France). Rapidec® Carba NP (Biomerieux, France) was used to investigate carbapenemase production followed by antibiotic susceptibility testing through Kirby-Bauer Disc Diffusion method and agar dilution method. Class D carbapenemase genes were targeted through PCR assay followed by investigation of horizontal transmission of blaOXA-58 and blaOXA-78. Whole genome sequencing was carried out using Illumina platform to investigate the genetic context of blaOXA-58 and blaOXA-78 genes and further characterization of the CRE isolates.Results The carbapenem resistant Escherichia coli (BJD_EC456) and Serratia marcescens (BJD_SM81) received during the study from the tertiary referral hospital were isolated from sputum and blood samples respectively. PCR assay followed by whole genome sequencing revealed that the isolates co-harbor blaOXA-58 and blaOXA-78, a variant of blaOXA-51. Horizontal transfer of blaOXA-58 and blaOXA-78 genes were unsuccessful as these genes were located on the chromosome of the study isolates. Transposon Tn6080 was linked to blaOXA-78 in the upstream region while the insertion sequences ISAba26 and ISCfr1 were identified in the upstream and downstream region of blaOXA-58 gene respectively. In addition, both the isolates were co-harboring multiple antibiotic resistance genes conferring clinical resistance towards beta-lactams, aminoglycosides, fluroquinolones, sulphonamides, tetracyclines. BJD_EC180 belonged to ST2437 while BJD_SM81 was of an unknown sequence type. The nucleotide sequences of blaOXA-78 (OQ533021) and blaOXA-58 (OQ533022) have been deposited in GenBank.Conclusions The study provides a local epidemiological information regarding carbapenem resistance aided by transposon and insertion sequences associated blaOXA-78 and blaOXA-58 genes associated and warrants continuous monitoring to prevent their further dissemination into carbapenem non-susceptible strains thereby contributing to carbapenem resistance burden which is currently a global concern.
The influence of implant position and of prosthetic characteristics on the occurrence of peri-implantitis: a retrospective study on periapical radiographs
Authors: CORBELLA Stefano , MORANDI Benedetta , CALCIOLARI Elena , ALBERTI Alice , FRANCETTI Luca , DONOS Nikos 
Published: June 2023

Abstract
Objective
The present retrospective study aimed to investigate how implant position and the characteristics of the implant-supported prosthesis may influence the occurrence of peri-implantitis.
Materials and methods
The study included systemically healthy patients with single and partial implant-supported rehabilitations and at least 1-year post-loading follow-up. The parameters collected included implant-related factors, patient-related factors, site-related factors and prosthesis-related factors. The radiographic measurements were taken by using a dedicated software and the diagnosis of peri-implantitis was made based on all the available clinical and radiographic data. Descriptive statistics were provided for all variables. Following an exploratory approach, an implant-level analysis of factors influencing the occurrence of peri-implantitis was done through a multilevel multivariate logistic regression (mixed).
Results
A total of 180 implants belonging to 90 subjects were randomly selected. According to the multi-level analysis, the parameters that were significantly associated with peri-implantitis included presence / history of periodontitis (OR = 5.945, 95% CI: 1.093–32.334, P = 0.039) and presence of an emergence profile angle ≥ 45° (OR 9.094, 95% CI: 2.017–40.995, P = 0.005).
Conclusions
History of periodontitis and presence of a prosthetic emergence profile with an angle ≥ 45° were correlated to an increased risk of peri-implantitis. Conversely, we did not find a correlation between peri-implantitis and implant malposition.
Genetic diversity and marker trait association analysis for grain quality, yield and yield attributes in hilly rice of North-Eastern Himalayan region
Authors: Verma Harendra , Theunuo Sakuonuo , Das S P , Sarma R N , Kumar Amit , Choudhury BU , Baishya L K , Devi Lamalakshmi , Sarika Konsam , Aochen C , Bordoloi L J , Rajkhowa D J , Kalita H , Mishra V K 
Published: June 2023

Abstract
Background: The demand for quality rice is increasing due to the influence of population growth and rising living standards. North eastern region of India is considered as centre of origin of rice and has diversified rice landraces with unique cooking quality and yield attributing traits. The studies on genetic diversity and marker-trait association analysis of north-eastern hilly rice for grain quality and yield attributes are of enormous importance for the identification of promising rice genotypes with better grain and cooking quality vis a vis markers associated with grain quality and yield attributes. This will assist in development of high-yielding cultivars.
Results: Genetic diversity among 130 rice genotypes of North East India and marker-trait association was assessed using genotypic data of 90 SSR markers and phenotypic data. The phenotypic diversity analysis showed considerable variation across genotypes for grain quality, yield and yield-attributing traits. The principal component analysis revealed that plant height, panicle length, spikelet fertility, decorticated grain length and width, days to maturity, days to 50% flowering, and grain yield govern the diversity. Population structure analysis, distance-based neighbour joining cluster and principal coordinate analysis using genotypic data grouped the genotypes into two sub-populations. Analysis of molecular variance and pairwise FST values showed significant differentiation among all the pairs of sub-population. Marker trait association analysis using the mixed linear model revealed a total of six associations at P < 0.0001 for grain quality and yield attributing traits with R2 ranging from 3.55 to 11.91% under the upland ecosystem. The present study validated the association of RM240 marker with Gel consistency for use in MAS and existence of plant height gene on chromosome 3. The study indicated the presence of novel QTLs for days to maturity with RM210 and RM105 and days to flowering with RM101 under consideration.
Conclusions: The present study suggests that the diverse germplasm of NE India and identified markers could be used in rice breeding programs for the improvement of grain quality and yield attributes.