bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sequential Structural Evolution Triggered by O─O Dimerization in Oxygen‐Redox Reactions
Authors: Shi Xiang‐Mei , Kawai Kosuke , Okubo Masashi , Yamada Atsuo 
Published: February 2025

AbstractThe participation of oxygen in electrochemical reactions increases the capacity of lithium‐ion battery positive electrodes beyond conventional cationic‐redox limits. However, structural degradation due to oxidized oxide ions significantly reduces the discharge voltage compared with that in the first charge, mostly with a capacity loss. In this study, it is shown that O─O dimerization triggers transition‐metal migration in an oxygen‐redox positive electrode upon charging. First‐principles calculations are performed to reveal the thermodynamic and kinetic energy landscapes of the full structural evolution of a typical lithium‐rich oxide, i.e., Li1.2Ni0.13Co0.13Mn0.54O2. The oxygen oxidation process can be divided into three sequential steps: i) generation of persistent oxidized oxide ion O−; ii) peroxide formation; and iii) transition‐metal migration. The elusive use of O2−/O− while blocking O─O dimerization is the key to avoiding structural degradation due to transition‐metal migration and realizing energy‐efficient oxygen‐redox reactions.
Spongy Silicon‐Doped MoS2 via Long‐Chain Molecule Induction and Mesopore Confinement for Ultra‐Stable Lithium‐Ion Storage
Authors: Pei Kewei , Huang Senchuan , Cao Yangfei , Zhong Jianwei , Li Meng , Long Hao , Chen Hao , Li Dong‐Sheng , Zhang Shanqing 
Published: February 2025

AbstractLayered transition metal dichalcogenides (LTMDs), such as MoS2, are promising anode materials for high‐energy‐density lithium‐ion batteries (LIBs) due to their high specific capacities. However, their practical applications are hindered by poor cycling stability resulting from the instable structure during charge/discharge and inherently low electronic conductivity. To tackle these issues, herein, this study presents the design and synthesis of spongy silicon‐doped MoS2 induced by the long‐chain molecules in mesopores. The material consists of few‐layered nanofragments with high porosity, resulting in abundant edge sites and sulfur vacancies. These structural features can promote Li+ transport and accommodate electrode volume changes during charge/discharge. Electrochemical and theoretical analyses reveal that silicon doping enhances the electronic conductivity of MoS2, while the nanostructure design enables reversible Li⁺ diffusion along the edges, distinct from Li+ storage in the interlayers of conventional MoS2 anodes. Notably, the material delivers a high reversible capacity of 767.9 mAh g−1 at 0.1 A g−1 and exhibits remarkable rate capability. Moreover, it demonstrates superior cycling stability with over 83% capacity retention even after 1000 cycles at 1.0 A g−1, outperforming most existing MoS2‐based anode materials. This work paves a new way for designing high‐performance LTMD‐based anodes for LIBs and beyond.
Distinct Alterations of Inflammatory Biomarkers in Cluster Headache: A Case Control Study
Authors: Lund Nunu Laura Timotheussen , Westgate Connar Stanley James , Søborg Marie‐Louise Kulas , Snoer Agneta Henriette , Jensen Rigmor Højland , Hansen Thomas Folkman , Petersen Anja Sofie 
Published: February 2025

ObjectiveInvestigate the immune system's role in cluster headache by analyzing cytokines in people with cluster headache and headache‐free controls, and explore if certain cytokines could predict a specific phenotype.MethodsWe measured 45 cytokines in adult participants from the Danish Cluster Headache Biobank in a prospective case–control setup. People with cluster headache were diagnosed according to the International Classification of Headache Disorders third‐edition. Controls were matched for age and sex.ResultsA total of 412 were analyzed deriving from 99 with chronic cluster headache, 108 with episodic cluster headache (ECH) in bout, 105 with ECH in remission, and 100 successfully matched controls. Compared with controls, 13 cytokines were altered for ECH in bout (p < 0.05), 3 in remission (p < 0.05), and 10 for chronic cluster headache (p < 0.05). Oncostatin m was significantly elevated in all 3 disease states compared with controls (p < 0.05). Overall, the investigated cytokines showed distinct patterns of alterations between chronic cluster headache and episodic cluster headache in bout and, interestingly, IL‐1β was significantly associated with having chronic cluster headache rather than episodic in bout in a logistic regression model adjusting for potential confounders (p < 0.05).InterpretationFindings show that the immune system is altered in all 3 states of cluster headache compared with controls. Oncostatin m was elevated, constituting a promising target for future studies. The distinct alterations between episodic and chronic cluster headache are striking and urges further research of the immune system in cluster headache to better understand its potential role in prediction of disease activity and treatment response. ANN NEUROL 2025
Fluoxetine Treatment in Epilepsy of Infancy with Migrating Focal Seizures Due to KCNT1 Variants: An Open Label Study
Authors: Trivisano Marina , Mosca Ilaria , Salimbene Licia , De Dominicis Angela , Ambrosino Paolo , Puzo Deborah , Servettini Ilenio , Correale Cinzia , Falamesca Chiara , Filosomi Cristina , Goffredo Bianca , Soldovieri Maria Virginia , Taglialatela Maurizio , Specchio Nicola 
Published: February 2025

ObjectiveGain‐of‐function (GoF) variants in KCNT1 encoding for potassium channels are associated with different epilepsy phenotypes, including epilepsy of infancy with migrating focal seizures (EIMFS), other early infantile developmental and epileptic encephalopathies, and focal epilepsy. Fluoxetine blocks currents from both wild‐type (WT) and mutant KCNT1 channels with GoF in vitro features. In this study, we tested the hypothesis that treatment with fluoxetine might improve clinical outcome in patients with EIMFS carrying GoF variants in KCNT1 channels showing in vitro sensitivity to fluoxetine blockade.MethodsWe enrolled three pediatric patients carring de novo KCNT1 genetic variants linked to EIMFS. Functional and pharmacological studies to assess fluoxetine's ability to counteract in vitro variant‐induced functional effects were performed with patch‐clamp electrophysiology on heterologous channel expression in mammalian Chinese hamster ovary cells. Neuropsychological assessment, electroencephalogram and seizure diary were evaluated at baseline and every 3 months during the study. Electrocardiography and blood levels of medications were monitored for safety.ResultsAll 3 KCNT1 variants displayed GoF effects in vitro. Exposure to fluoxetine (10μM) blocked both WT and mutant KCNT1 channels, therefore, counteracting variant‐induced functional effects. Treatment with fluoxetine caused a variable reduction of seizure frequency (25–75%). Improvement in visual attention, participation, and muscle tone was also reported. No adverse events were reported except for transient dyskinesia in 1 patient, which was probably related to an increase in fluoxetine plasma level.InterpretationFluoxetine may be a potential targeted medication in EIMFS caused by KCNT1 GoF variants. Further research is needed to assess its long‐term efficacy and safety. ANN NEUROL 2025
Interfacial Asymmetrically Coordinated Zn−MOF for High‐Efficiency Electrosynthetic Oxime
Authors: Kang Jiawei , Liao Peisen , Xiang Runan , Liao Wenpei , Yang Chenyu , Wang Shihan , Liu Qinghua , Li Guangqin 
Published: February 2025

AbstractOximes are important intermediates for various chemicals synthesis such as pharmaceuticals, among which one vital precursor for producing neurological disease, antimicrobial and anticancer agents is piperidone oxime (PDO). Compared with conventional thermocatalytic method, it's more attractive to synthesize PDO via green electrocatalytic technology especially utilizing waste nitrogen oxides gas as nitrogen source. However, there are great challenges in catalyst design for high‐efficiency electrosynthetic oxime due to the low electron transport rate and multiple competing reactions. Herein, we propose an interfacial coordination strategy based on metal–organic frameworks (MOF) electrocatalyst for the first time to promote oxime electrosynthesis, by building Zn−O bridges between graphite felt (GF) and zeolitic imidazolate framework (ZIF‐7/CGF). Specially, ZIF‐7/CGF delivers a Faraday efficiency (FE) of 75.9 % with yield up to 73.1 % for 1‐methyl‐4‐piperidone oxime, which is far superior to the catalyst without Zn−O bridges (a FE of 10.7 % and yield of 10.3 %). In‐depth mechanism study shows that the introducing Zn−O bridges can promote the electron transfer and induce Zn sites transforming into distorted tetrahedron (Zn‐N3O) coordination mode, which benefits for intermediates adsorption and conversion. The developed strategy presents wide universalities towards various oximes electrosynthesis and adapts to other MOF materials (ZIF‐8, ZIF‐4). This work provides new insights for electrosynthetic organic chemicals and upgrading nitrogen cycle through rational design surficial coordinated electrocatalysts.
Evolutionary Origins and Adaptive Significance of A‐to‐I RNA Editing in Animals and Fungi
Authors: Du Yanfei , Wang Chenhui , Zhang Yu , Liu Huiquan 
Published: February 2025

ABSTRACTAdenosine‐to‐inosine (A‐to‐I) RNA editing, capable of protein recoding, has evolved independently in animals and fungi. This study proposes adaptive hypotheses regarding its origins and phenotypic significance, suggesting that A‐to‐I editing enhances adaptability by alleviating genetic trade‐offs. In metazoans, its emergence may have been driven by a development‐defense trade‐off associated with transposable element activation during the evolution of multicellularity. Late Devonian cooling and End‐Permian warming are hypothesized to have driven the emergence of extensive A‐to‐I recoding in coleoid nervous systems and Sordariomycete sexual fruiting bodies, respectively. These adaptations may have influenced key evolutionary innovations, including the evolution of metazoan nervous systems, coleoid intelligence, and shell loss, and fungal sexual reproductive structures. Additionally, extensive A‐to‐I recoding is proposed to facilitate accelerated development and specific life‐history strategies in both animals and fungi. This paper provides new perspectives on the evolutionary forces shaping A‐to‐I RNA editing and its role in phenotypic diversity across taxa.
Fostering Love for Innovative Sustainable Brands: A Multi‐Study, Multi‐Method Approach
Authors: Fazal‐e‐Hasan Syed Muhammad , Adil Mohd , Ahmadi Hormoz , Abid Muhammad , Sadiq Mohd , Mortimer Gary , Amrollahi Alireza 
Published: February 2025

ABSTRACTWhile much research has examined cognitive evaluations of sustainable brands in offline contexts, there is limited exploration of consumers' emotional responses to such brands online. This study introduces a model of brand love for innovative, sustainable brands, based on two rigorously designed studies: experiments and a survey with configurational analysis. Our findings reveal significant causal effects of perceived brand innovativeness and brand knowledge on brand love and consumers' repurchase intentions. Additionally, fuzzy set qualitative comparative analysis (fsQCA) identifies two distinct consumer categories—rational and impulsive—based on their repurchase behavior of sustainable brands. For business owners and sustainability advocates, fostering brand love is crucial for engaging consumers online. By integrating emotional appeal with a commitment to sustainability, brands can enhance consumer engagement, encourage repeat purchases, and contribute to a more sustainable online shopping environment.
Headspace Volatiles, Macro‐ and Microelements of the Root and Leaf of the Hylotelephium H. Ohba Species, Hybrids and Cultivars as Variables for Their Differentiation
Authors: Jevtović Snežana , Tošić Snežana B. , Mrmošanin Jelena M. , Mitić Zorica S. , Đukić Miloš G. , Stojanović Gordana S. 
Published: February 2025

This study aimed to analyse the chemical profiles of Hylotelephium species, hybrids, and cultivars in terms of headspace (HS) volatiles (by GC‐MS/FID) and elemental composition (macro‐/microelements) of roots and leaves (by ICP‐OES). Contrary to the root HS fraction, the HS fraction of the leaf did not contain any volatiles. Generally, oxygenated monoterpenes are a dominant class of root HS volatiles, with monoterpenic alcohol myrtenol as a major compound followed by 1‐octen‐3‐ol. Regarding the content of macroelements, the analyzed samples mostly contained the highest content of Ca or K and the smallest content of Na. Among microelements, Fe, Mn, and Zn were the most abundant in the root. Interestingly, the highest content of most microelements was detected in the studied species. Regarding the translocation factors (TF) for toxic elements, hybrids and cultivars proved better for accumulating heavy metals than species. Overall, both chemical profiles were statistically processed using multivariate analysis (AHC and PCA) to observe the tendency of grouping based on the chemical composition. According to the HS volatile pattern, a hybrid H. ‘Matrona’ and studied species were most separated, while macro‐ and microelements made the species root stand out most. H. ‘Matrona’ showed the greatest potential for the translocation.
Comparative Efficacy and Safety of Low‐Dose Direct Oral Anticoagulants Versus Dual Antiplatelet Therapy Following Left Atrial Appendage Occlusion in Patients With Nonvalvular Atrial Fibrillation: A Systematic Review and Meta‐Analysis
Authors: Ibrahim Ahmed , Shalabi Laila , Zreigh Sofian , Ramadan Shrouk , Mourad Sohaila , Eljadid Ghaith , Beshr Mohammed , Abdelaziz Ali , Elhadi Muhammed , Sabouret Pierre , Mamas Mamas 
Published: February 2025

ABSTRACTBackgroundLeft atrial appendage occlusion (LAAO) is an alternative to chronic oral anticoagulation (OAT) for stroke prevention in nonvalvular atrial fibrillation (NVAF) patients with contraindications to OAT. Postprocedure antithrombotic therapy (ATT) is essential to reduce the risk of device‐related thrombosis (DRT), but the optimal regimen remains uncertain.AimsThis study aims to compare the safety and efficacy of low‐dose direct oral anticoagulants (DOACs) versus dual antiplatelet therapy (DAPT) following LAAO.MethodsA comprehensive search of PubMed, Scopus, Cochrane, and Web of Science was conducted in August 2024. Studies comparing low‐dose DOACs and DAPT post‐LAAO were included. The primary outcomes were a composite efficacy endpoint (DRT, strokes, and systemic embolism [SE]) and major bleeding events as the safety endpoint. Secondary outcomes included all bleeding events, all‐cause mortality, and a composite of efficacy and safety endpoints.ResultsFour studies with 727 patients were included. Low‐dose DOACs were associated with lower rates of the primary composite efficacy endpoint compared to DAPT (OR = 0.36; 95% CI [0.16, 0.85], p = 0.01). No significant difference in major bleeding events was observed (OR = 0.36; 95% CI [0.11, 1.18]; p = 0.091; I² = 0%). Compared to DAPT, low‐dose DOACs were also associated with lower rates of DRT events (OR = 0.36; 95% CI [0.16, 0.79], p = 0.011).ConclusionLow‐dose DOACs effectively reduce thromboembolic events post‐LAAO without increasing bleeding risk. These findings support their use as a viable ATT option, but larger trials are needed to confirm optimal regimens.
Protocolised Management of Acute Myocardial Infarction Complicated by Cardiogenic Shock in Australia—Initial Experience From a Hub‐and‐Spoke Model
Authors: Backhouse Brendan , Dade Fabien , Bloom Jason E. , Xiao Xiaoman , Haji Kawa , Yang Yang , French Craig , Stub Dion , Nanjayya Vinodh , Lo Sidney , Chiang Michael , Basir Mir B. , O'Neill William , Noaman Samer , Al‐Mukhtar Omar , Kaye David , Cox Nicholas , Chan William 
Published: February 2025

ABSTRACTBackgroundAcute myocardial infarction complicated by cardiogenic shock (AMICS) confers short‐term mortality of 40%–50%. Protocolised network management of AMICS patients as part of a hub‐and‐spoke model supported by upstream mechanical circulatory support (MCS) is gaining traction globally to treat AMICS.MethodWe conducted a prospective multicenter study in Melbourne, Australia describing our 5‐year experience utilizing a protocolised hub‐and‐spoke model of care for patients with AMICS supported by planned upstream use of Impella CP (Abiomed, Danvers, MA).ResultsFrom December 2019 to August 2024, 31 patients were treated for AMICS with Impella MCS support. Median age was 60 years and 87% were males. ST‐elevation myocardial infarction accounted for 84% of presentations, and 29% were complicated by cardiac arrest. The majority of patients treated were in SCAI‐CSWG stage D (52%), and stage C (26%) shock. Upstream Impella prior to PCI occurred in 84% of patients. The 30‐day survival rate was 74%. An adverse event occurred in 39% of patients. Device‐related complications were due to hemolysis (32%) and arrhythmia (3%). Escalation of MCS support was required in five patients (16%). Multivariate analysis identified patients requiring transfer to the hub center prior to revascularisation as an independent predictor of mortality (OR 13.2 [1.34–129.3] p = 0.027).ConclusionIn this first protocolised hub‐and‐spoke model of care for AMICS supported by planned upstream use of Impella in Australia, 30‐day survival was high compared to published historical rates. Patient and device‐related complication rates were low. Expansion of the hub‐and‐spoke model for the treatment of AMICS appears warranted.
ECL‐Based Readout of Electric Field‐Induced Fine‐Tuning of Redox Activity
Authors: Zhou Changlin , Arias‐Aranda Leslie R. , Salinas Gerardo , Bouffier Laurent , Wang Zonghua , Kuhn Alexander , Sojic Neso 
Published: February 2025

AbstractMagnesium, a highly reactive alkaline earth metal, acts spontaneously as a strong reducing agent. In this work, the redox reactivity of Mg is fine‐tuned selectively in a wireless manner by means of bipolar electrochemistry (BE). This is demonstrated by mapping the spatial electroactivity of Mg via the electrochemiluminescence (ECL) emission of the Ru(bpy)32+/S2O82− system. Asymmetric ECL patterns are obtained by controlling the applied external electric field. The ECL intensity is increased by up to approximately 80 % at the cathodic extremity whereas a 50 % decrease is observed at the anodic side of a bipolar electrode. Additionally, the influence of the spatial distribution of the electric field on the reactivity of Mg and its concomitant ECL emission is evaluated, producing complex luminescent patterns. These findings, illustrate the wireless modulation of redox reactivity by BE.
CO Generation from CO2 Using an Atmospheric Microwave Plasma Process
Authors: Bresser Marc , Wiegers Katharina , Schulz Andreas , Walker Matthias , Tovar Günter E. M. 
Published: February 2025

AbstractWith rising CO₂ levels and climate change, finding alternatives to fossil fuels is essential. One attractive option is converting CO₂ into CO and O₂ via an atmospheric microwave plasma process. This study evaluates conversion and energy efficiency by increasing microwave power and CO₂ flow. Power and CO₂ flow were varied, with conversion measured using Fourier transform‐infrared spectroscopy, mass spectrometry, and gas analysis. A maximum conversion of 21.1 % was achieved at a specific energy input of 1.1 eV molecule−1, highlighting the potential of this approach for efficient CO₂ utilization.
Stirrerless Mixing of Liquids in Large Containers and Vessels
Authors: Weber Manfred , Thomé Andreas G. , Hapke Mark , Meier zu Greffen Aike 
Published: February 2025

AbstractJet mixing or gravity‐driven mixing by rising gas bubbles can be applied for homogenization of liquids in tanks (→ concentration or temperature) or for shortstopping of reactions (injecting an inhibitor or a cooling/diluting liquid). Whereas the mixing efficiency of gas bubbles in large bubble column reactors at superficial gas velocities above 2 cm s−1 is well‐known, less information is available for significantly lower gas flow rates below 1 mm s−1 (→ bubble plumes). This can be applied to enhance heat transfer for cooling down a stagnant liquid in a reactor after a shutdown. These mixing processes are reviewed and demonstrated by large‐scale field tests. The application of the axial dispersion model to evaluate mixing times is discussed.
Significant Progress in the Study of African Freshwater Snails Over the Past 260 Years
Authors: Ziganira Matabaro , Downs Colleen T. 
Published: February 2025

ABSTRACTGlobally, freshwater ecosystems are threatened. Research progress concerning African freshwater snails was reviewed using a systematic review process. Since 1757, the number of publications produced has increased, particularly in the last decade. In the first 50 years (1757–1800), 0.1% of publications on freshwater snails in Africa were conducted, followed by 0% (1801–1850), 3.3% (1851–1900), 3.5% (1901–1950) and 48.7% (1951–2000). The last 23 years (2001–2024) exhibited a large increase (44.3%) in publications of the total conducted. Studies on freshwater snails varied in number across the 10 major African water basins, with the majority of studies in the Nile (21.7%), followed by the Congo Basin (17.6%) and Niger (12.4%). The Orange Basin and Lake Tanganyika also received a high number of studies (10.9%) and (7.2%), respectively. Most freshwater snail study objectives related to conservation and taxonomy (70%), followed by disease vector (20.5%), with genetics/genomic/DNA barcoding/eDNA receiving significant focus as well (5.2%). Studies focusing on geology and palaeontology (2.5%), followed by climate change (1.5%) and machine learning (0.4%). The modern phase in the study of African freshwater snails came around the early 20th century with the discovery of Bulinus truncatus and Biomphalaria alexandrina as intermediate hosts for the parasites causing human schistosomiasis. African freshwater malacology has since then benefited from African and overseas malacologists based at universities and medical laboratories across Africa and overseas. In addition to taxonomic studies, there was a steady rise in contributions relating to ecology, disease vectors, palaeontology and genetics. These contributed knowledge on local endemism and speciation, invasive species, species origins and distribution across African water basins, as well as the spread of infectious diseases and impacts of climate change. In the last decade, there have been shifts in methods with the application of DNA barcoding, genomics, environmental DNA and, most recently, machine learning approaches.