bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inactivation of interleukin-30 in colon cancer stem cells via CRISPR/Cas9 genome editing inhibits their oncogenicity and improves host survival
Authors: D'Antonio Luigi , Fieni Cristiano , Ciummo Stefania Livia , Vespa Simone , Lotti Lavinia , Sorrentino Carlo , Di Carlo Emma 
Published: March 2023

BackgroundProgression of colorectal cancer (CRC), a leading cause of cancer-related death worldwide, is driven by colorectal cancer stem cells (CR-CSCs), which are regulated by endogenous and microenvironmental signals. Interleukin (IL)-30 has proven to be crucial for CSC viability and tumor progression. Whether it is involved in CRC tumorigenesis and impacts clinical behavior is unknown.MethodsIL30 production and functions, in stem and non-stem CRC cells, were determined by western blot, immunoelectron microscopy, flow cytometry, cell viability and sphere formation assays. CRISPR/Cas9-mediated deletion of theIL30gene, RNA-Seq and implantation ofIL30gene transfected or deleted CR-CSCs in NSG mice allowed to investigate IL30’s role in CRC oncogenesis. Bioinformatics and immunopathology of CRC samples highlighted the clinical implications.ResultsWe demonstrated that both CR-CSCs and CRC cells express membrane-anchored IL30 that regulates their self-renewal, via WNT5A and RAB33A, and/or proliferation and migration, primarily by upregulating CXCR4viaSTAT3, which are suppressed by IL30 gene deletion, along with WNT and RAS pathways. Deletion ofIL30gene downregulates the expression of proteases, such as MMP2 and MMP13, chemokine receptors, mostly CCR7, CCR3 and CXCR4, and growth and inflammatory mediators, including ANGPT2, CXCL10, EPO, IGF1 and EGF. These factors contribute to IL30-driven CR-CSC and CRC cell expansion, which is abrogated by their selective blockade.IL30gene deleted CR-CSCs displayed reduced tumorigenicity and gave rise to slow-growing and low metastatic tumors in 80% of mice, which survived much longer than controls. Bioinformatics and CIBERSORTx of the ‘Colorectal Adenocarcinoma TCGA Nature 2012’ collection, and morphometric assessment of IL30 expression in clinical CRC samples revealed that the lack of IL30 in CRC and infiltrating leucocytes correlates with prolonged overall survival.ConclusionsIL30 is a new CRC driver, since its inactivation, which disables oncogenic pathways and multiple autocrine loops, inhibits CR-CSC tumorigenicity and metastatic ability. The development of CRISPR/Cas9-mediated targeting of IL30 could improve the current therapeutic landscape of CRC.
Late Triassic granites with mafic microenclaves in the East Kunlun Orogenic Belt, northwestern China: petrogenesis and implications for continental crust evolution and geodynamic evolution
Authors: Xin Wei , Ding Zheng-jiang , Meng Yuan-ku , Bo Jun-wei , Li Liang , Mao Guang-zhou 
Published: March 2023

The magmatic source of the Late Triassic granites in the East Kunlun Orogenic Belt (EKOB) is controversial, which restricts our understanding of crustal evolution and geodynamic evolution in the EKOB. Therefore, this study conducts zircon U‒Pb isotope dating, major and trace geochemical analysis, electron microprobe analysis of feldspar and amphibole, and in situ zircon Hf isotope analysis of Xiangride host granites and their mafic microgranular enclaves (MMEs) in the EKOB to reveal their magmatic source and geodynamic implications. Zircon U‒Pb dating shows that the Xiangride host granites and the MMEs crystallized simultaneously at ca. 228–223 Ma. The MMEs show an igneous texture, finer grain size, higher crystallization temperature and water content, and lower oxygen fugacity than those of the host granite, suggesting that they were probably derived from two distinct primitive magmas. Therefore, the MMEs are considered the products of magma mixing between granitic and mafic magmas. The Xiangride host granites show high Sr/Y (42.0–73.1) and (La/Yb)N (12.7–30.7) ratios, showing affinity with adakites derived from a thickened lower crust. Combined with the indistinguishable εHf(t) values (−3.47 to +0.08) from the coeval mafic rocks, it is concluded that they are derived from partial melting of juvenile thickened lower crust. The adakitic features of the Xiangride host granites and widespread coeval granites indicate the existence of a thickened lower crust before 228 Ma and delamination of the lower lithosphere is likely the geodynamic process resulting in the postcollisional extension regime.
Exploring coherent elastic neutrino-nucleus scattering using reactor electron antineutrinos in the NEON experiment
Authors: Choi J. J. , Jeon E. J. , Kim J. Y. , Kim K. W. , Kim S. H. , Kim S. K. , Kim Y. D. , Ko Y. J. , Koh B. C. , Ha C. , Park B. J. , Lee S. H. , Lee I. S. , Lee H. , Lee H. S. , Lee J. , Oh Y. M. ,   NEON Collaboration
Published: March 2023

AbstractNeutrino elastic scattering observation with NaI (NEON) is an experiment designed to detect neutrino-nucleus coherent scattering using reactor electron antineutrinos. NEON is based on an array of six NaI(Tl) crystals with a total mass of 13.3 kg, located at the tendon gallery that is 23.7 m away from a reactor core with a thermal power of 2.8 GW in the Hanbit nuclear power complex. The installation of the NEON detector was completed in December 2020, and since May 2021, the detector has acquired data at full reactor power. Based on the observed light yields of the NaI crystals of approximately 22, number of photoelectrons per unit keV electron-equivalent energy (keVee), and 6 counts/kg/keV/day background level at 2–6 keVee energy, coherent elastic neutrino-nucleus scattering (CE$$\nu $$
ν
NS) observation sensitivity is evaluated as more than 3$$\sigma $$
σ
assuming 1-year reactor-on and 100 days reactor-off data, 0.2 keVee energy threshold, and 7 counts/keV/kg/day background in the signal region of 0.2$$-$$
-
0.5 keVee. This paper describes the design of the NEON detector, including the shielding arrangement, configuration of NaI(Tl) crystals, and associated operating systems. The initial performance and associated sensitivity of the experiment are also presented.
Weak radiative decay $$\Lambda _{c}^{+}\rightarrow \Sigma ^{+}\gamma $$ using light-cone sum rules
Authors: Shi Yu-Ji , Xing Zhi-Peng , Meißner Ulf-G. 
Published: March 2023

AbstractWe calculate the decay width of the $$\Lambda _{c}^{+}\rightarrow \Sigma ^{+}\gamma $$

Λ

c

+

→

Σ
+

γ

using light-cone sum rules. For the initial quark radiation an effective Hamiltonian is constructed, where the internal quark line shrinks to a point. The final quark radiation is studied within the full theory. The leading twist light-cone distribution amplitudes of the $$\Sigma ^+$$

Σ
+

serve as the non-perturbative input for the sum rules calculation, and the perturbative kernel is calculated at leading order. The branching fraction we obtain is $$\mathcal{B}(\Lambda _{c}^{+}\rightarrow \Sigma ^{+}\gamma )=1.03\pm 0.36 \times 10^{-4}$$

B

(

Λ

c

+

→

Σ
+

γ
)

=
1.03
±
0.36
×

10

-
4

, which is below the recent upper limits $$<2.6 \times 10^{-4}$$

<
2.6
×

10

-
4

and $$<4.4 \times 10^{-4}$$

<
4.4
×

10

-
4

given by the Belle collaboration and the BESIII collaboration, respectively.
Multi-representation dynamics of SU(4) composite Higgs models: chiral limit and spectral reconstructions
Authors: Del Debbio Luigi , Lupo Alessandro , Panero Marco , Tantalo Nazario 
Published: March 2023

AbstractWe present a lattice study of the SU(4) gauge theory with two Dirac fermions in the fundamental and two in the two-index antisymmetric representation, a model close to a theory of partial compositeness proposed by G. Ferretti. Focus of this work are the methodologies behind the computation of the spectrum and the extrapolation of the chiral point for a theory with matter in multiple representations. While being still technical, this study provides important steps towards a non-perturbative understanding of the spectrum of theories of partial compositeness, which present a richer dynamics compared to single-representation theories. The multi-representation features are studied first in perturbation theory, and then non-perturbatively by adopting a dual outlook on lattice data through a joint analysis of time-momentum correlation functions and smeared spectral densities.
Ringing and echoes from black bounces surrounded by the string cloud
Authors: Yang Yi , Liu Dong , Xu Zhaoyi , Long Zheng-Wen 
Published: March 2023

AbstractIn the string theory, the fundamental blocks of nature are not particles but one-dimensional strings. Therefore, a generalization of this idea is to think of it as a cloud of strings. Rodrigues et al. embedded the black bounces spacetime into the string cloud, which demonstrates that the existence of the string cloud makes the Bardeen black hole singular, while the black bounces spacetime remains regular. On the other hand, the echoes are the correction to the late stage of the quasinormal ringing for a black hole, which is caused by the deviation of the spacetime relative to the initial black hole spacetime geometry in the near-horizon region. In this work, we study the gravitational wave echoes of black bounces spacetime surrounded by a cloud of strings under scalar field and electromagnetic field perturbation to explore the effects caused by a string cloud in the near-horizon region. The ringing of the regular black hole and traversable wormhole with string cloud are presented. Our results demonstrate that the black bounce spacetime with strings cloud is characterized by gravitational wave echoes as it transitions from regular black holes to wormholes, i.e. the echoes signal will facilitate us to distinguish between black holes and the wormholes in black bounces surrounded by the string cloud.
Probing Aesthetics Strategies for Robot Sound: Complexity and Materiality in Movement Sonification
Authors: Latupeirissa Adrian B. , Panariello Claudio , Bresin Roberto 
Published: March 2023

This article presents three studies where we probe aesthetics strategies of sound produced by movement sonification of a Pepper robot by mapping its movements to sound models.
We developed two sets of sound models. The first set was made by two sound models, a sawtooth-based one and another based on feedback chains, for investigating how the perception of synthesized robot sounds would depend on their design complexity. We implemented the second set of sound models for probing the “materiality” of sound made by a robot in motion. This set consisted of a sound synthesis based on an engine highlighting the robot’s internal mechanisms, a metallic sound synthesis highlighting the robot’s typical appearance, and a whoosh sound synthesis highlighting the movement.
We conducted three studies. The first study explores how the first set of sound models can influence the perception of expressive gestures of a Pepper robot through an online survey. In the second study, we carried out an experiment in a museum installation with a Pepper robot presented in two scenarios: (1) while welcoming patrons into a restaurant and (2) while providing information to visitors in a shopping center. Finally, in the third study, we conducted an online survey with stimuli similar to those used in the second study.
Our findings suggest that participants preferred more complex sound models for the sonification of robot movements. Concerning the materiality, participants liked better subtle sounds that blend well with the ambient sound (i.e., less distracting) and soundscapes in which sound sources can be identified. Also, sound preferences varied depending on the context in which participants experienced the robot-generated sounds (e.g., as a live museum installation vs. an online display).
On the Complexity of String Matching for Graphs
Authors: Equi Massimo , Mäkinen Veli , Tomescu Alexandru I. , Grossi Roberto 
Published: March 2023

Exact string matching in labeled graphs is the problem of searching paths of a graph
G=(V, E)
such that the concatenation of their node labels is equal to a given pattern string
P
[1.
m
]. This basic problem can be found at the heart of more complex operations on variation graphs in computational biology, of query operations in graph databases, and of analysis operations in heterogeneous networks.

We prove a conditional lower bound stating that, for any constant ε > 0, an
O
(|
E
|
1 - ε
m
) time, or an
O
(|
E
|
m
1 - ε
)time algorithm for exact string matching in graphs, with node labels and pattern drawn from a binary alphabet, cannot be achieved unless the Strong Exponential Time Hypothesis (
SETH
) is false. This holds even if restricted to undirected graphs with maximum node degree 2—that is, to
zig-zag matching in bidirectional strings
, or to
deterministic
directed acyclic graphs whose nodes have maximum sum of indegree and outdegree 3. These restricted cases make the lower bound stricter than what can be directly derived from related bounds on regular expression matching (Backurs and Indyk, FOCS’16). In fact, our bounds are tight in the sense that lowering the degree or the alphabet size yields linear time solvable problems.

An interesting corollary is that exact and approximate matching are equally hard (i.e., quadratic time) in graphs under
SETH
. In comparison, the same problems restricted to strings have linear time vs quadratic time solutions, respectively (approximate pattern matching having also a matching
SETH
lower bound (Backurs and Indyk, STOC’15)).
Improving the Probability of Stroke Detection inside the Human Head Using Wideband Polarimetric Synthetic Aperture Radar Imaging
Authors: Naghavi Amir H. , Hassani Hamid R. , Oloumi Daniel 
Published: March 2023

This paper presents an imaging system based on ultrawideband microwave radars for the detection of bleeding regions and strokes inside the human head. The proposed system is portable and focuses on revealing bleeding areas with unpredictable shapes using polarimetric data acquisition. A custom-designed dual-polarized bowtie patch antenna capable of pumping the UWB pulses inside the patient’s head is designed and presented as the biomedical sensor for the system. The antenna dimensions are

25
×
25

m

m

2

. It mitigates the mismatch between the air and skin needles of any coupling liquid, resulting in safe SAR levels below 0.5 W/kg and wideband operating bandwidth that covers 1.2-4.5 GHz with unidirectional radiations. To collect the raw polarimetric data, an elliptical array of the proposed antenna is formed around the patient’s head model that includes 16 elements in direct contact with the phantom. The performance of the proposed method is validated through an imaging scenario with two nonuniform bleeding areas inside the patient head model. The whole structure is simulated with a Gaussian pulse as the excitation using CST Microwave Studio tools. To produce 2D images of the voxel model, the time-domain elliptical synthetic aperture radar (ESAR) imaging algorithm is applied. Accurately detecting the presence and shape of anomalies in reconstructed images using the proposed method demonstrates the efficiency of the proposed system and determines its advantages over single-polarization systems.
Clonal Evolution in Healthy and Premalignant Tissues: Implications for Early Cancer Interception Strategies
Authors: Rane Jayant K. , Frankell Alexander M. , Weeden Clare E. , Swanton Charles 
Published: March 2023

Abstract
Histologically normal human tissues accumulate significant mutational burden with age. The extent and spectra of mutagenesis are comparable both in rapidly proliferating and post-mitotic tissues and in stem cells compared with their differentiated progeny. Some of these mutations provide increased fitness, giving rise to clones which, at times, can replace the entire surface area of tissues. Compared with cancer, somatic mutations in histologically normal tissues are primarily single-nucleotide variations. Interestingly though, the presence of these mutations and positive clonal selection in isolation remains a poor indicator of potential future cancer transformation in solid tissues. Common clonally expanded mutations in histologically normal tissues also do not always represent the most frequent early mutations in cancers of corresponding tissues, indicating differences in selection pressures. Preliminary evidence implies that stroma and immune system co-evolve with age, which may impact selection dynamics. In this review, we will explore the mutational landscape of histologically normal and premalignant human somatic tissues in detail and discuss cell-intrinsic and environmental factors that can determine the fate of positively selected mutations within them. Precisely pinpointing these determinants of cancer transformation would aid development of early cancer interventional and prevention strategies.
Sex Disparities in Diagnostic Evaluation and Revascularization in Patients With Acute Myocardial Infarction—A 15‐Year Nationwide Study
Authors: Ashraf Muddasir , Jan M. Fuad , Bajwa Tanvir. K , Carnahan Ryan , Zlochiver Viviana , Allaqaband Suhail Q. 
Published: March 2023

Background
Although sex disparities in the diagnostic evaluation and revascularization of patients with acute myocardial infarction are well documented, no study has evaluated longitudinal trends in these disparities.

Methods and Results

Using the National Inpatient Sample from 2005 to 2019, 9 259 932 patients with acute myocardial infarction were identified. We divided 15 years into five 3‐year periods. The primary objective was to evaluate sex‐based trends in the use of diagnostic angiography, percutaneous coronary intervention, and coronary artery bypass graft (CABG) among patients with non–ST‐segment–elevation myocardial infarction and ST‐segment–elevation myocardial infarction (STEMI) over 15 years. The secondary objective was to evaluate sex disparities in mortality, length of stay, and cost. For non–ST‐segment–elevation myocardial infarction, we saw a small reduction in sex disparity in the use of all diagnostic angiography in period 5 versus period 1 (4% versus 5.3%;
P
<0.01), no change in sex disparity in percutaneous coronary intervention use in period 5 versus period 1 (5.6% versus 5%;
P
=0.16), and a widening sex disparity in CABG in period 5 versus period 1 (5.4% versus 4.4%;
P
<0.01). However, we noted decreasing sex disparities in the use of diagnostic angiography, percutaneous coronary intervention, and CABG for ST‐segment–elevation myocardial infarction in mostly all periods compared with period 1 (
P
<0.05, all comparisons), but differences still existed in period 5. Risk‐adjusted in‐hospital mortality was higher after CABG for non–ST‐segment–elevation myocardial infarction and after percutaneous coronary intervention and CABG for ST‐segment–elevation myocardial infarction in women than men.

Conclusions
Despite variable trends in sex disparities in diagnostic and revascularization procedures for acute myocardial infarction, disparities still exist.
The EU’s Informal Readmission Agreements with Third Countries on Migration: Effectiveness over Principles?
Authors: Fernando-Gonzalo Elsa 
Published: March 2023

Abstract
Achieving faster and effective returns of irregular migrants is one of the priorities on the Pact on Migration and Asylum proposed by the European Commission. The Commission links the effectiveness of return to the enforcement of return decisions, which, although limited as an analytical benchmark, show that only 30% of return decisions are successful. To improve this ratio, the EU has recently resorted to informal readmission agreements or arrangements with third countries. Through these instruments, the process for binding international agreements established in the Treaties is bypassed. This type of non-binding instrument, generally covered under the ‘soft law’ label, generates major problems for the core principles of the EU legal order of institutional balance, judicial control, and transparency. The aim of this article is to analyse how these acts affect the three main principles of the legal system in the search for a more effective readmission policy using two case studies as the arrangements with Afghanistan and Bangladesh. The article concludes that the avoidance of the three principles does not result in a higher rate of returns.
Theology of Silence
Authors: Reese Naomi Noguchi 
Published: March 2023

Abstract
This article explores Endo Shusaku’s views of God and silence with the aim of sketching what I take to be Endo’s theology of silence. In service of this goal, I will delineate how Japanese culture and events in Endo’s life contributed to shaping his views of God and silence, which ultimately led to Endo’s theology of silence—one fitting his Japanese sensibilities. In Endo’s divine drama of silence, Christ, who is the eternal suffering companion, is the inhabiter of silence, while the Kakure Kirishitans—the oppressed and weary—are the pilgrims of silence. In the space of silence, ultimate beauty is revealed. God does not leave those who suffer alone; they are his to be comforted. Endo’s Christ is ineffectual to deliver from harm, yet he is effectual to comfort those who seemingly cannot be comforted and to love those who are seemingly unlovable.
Reacties In Griekenlanden Constantinopel Bij De Opheffing Van De Banvloek
Authors: Stephanou A.A E. 
Published: March 2023

Réaclion. la levée de l'anathème en Grèce et. Constanlinople.
Après un exposé détaillé des longues tractations entre l'Eglise catholique et celle de Constantinople, l'auteur décrit Ja cérémonie de la levée. l'Eglise patriarcale du Phanar et donne Ie texte de l'acte patriarcal et synodal. Suivent Jes réactions grecques défavorables de certains milieux d' organisations dites extra-ecclésiastiques qui ont réussi. entrainer dans leur camps Je vieil évêque d' Athènes, et de plusieurs organi­ sations religieuses. Cependant en Grèce les réactions favorables ont été beaucoup plus ,importantes et nombreuses: la grande presse du pays, les facultés de theologie d'Athènes et de Salonique, J'organisation des théologiens laïcs etc. Finalement l'auteur expose brièvement la réaction des chrétiens en Turquie. Il ne cache pas les faits désagréables par fidélité historique mais aussi pour souligner Ie courage du patriarche Athénagoras dont Ja force au milieu de la tempête constitue un phénomène plus qu'admirable.
De Reis van Paus Paulus Vi Naar Konstantinopel En Efeze En De Reacties In Griekenland
Authors: A.A. A. Aarns 
Published: March 2023

Le voyage du pape Paul VI. Constantinople et les réactions de la presse hellénique.
Le présent article décrit les étapes du voyage de SS. Paul VI. Constantinople et cite quelques passages significatifs des discours échangés. Les réactions de la presse hel­ lénique sont, dans l' ensemble, favorables. Rares sont les réactions qui marquent encore quelque méfiance.
Grieks-Melkitisch Patriarchaat van Antiochië op Zoek Naar Zijn Indentiteit
Authors: Raheb Abdallah 
Published: March 2023

Le patriarcat grec-melkite dʼAntioche. la recherche de son identité.
Le 31 octobre 1969 fut annoncée la nomination dʼun exarque pour les Melkites catholiques des Etats-Unis. Cʼétait la fin provisoire dʼun différend entre le patriarcat melkite et la Congrégation pour les Eglises orientales.. qui revient le droit de nommer un exarque melkite pour les régions “non-orientales”? Lʼauteur de lʼarticle se basant sur une publication récente,. lʼaide du décret Orientalium Ecclesiarum (Vatican II) examine le sens et le contenu du terme “territoire patriarcal”. En invoquant une Instruction de la Propagande Fide (1789) il croit pouvoir interpréter lʼexpression “les limites du territoire patriarcal” non dans un sens géographique, mais dans un sens numérique et existentiel, cʼest. dire elle indiquerait le nombre suffisant de clergé et de fidèles melkites nécessaire pour former un exarchat. Par conséquent cʼest le patriarche qui peut le constituer et nommer le nouvel évêque puisque la région se trouve. lʼintérieur de son patriarcat. Lʼauteur termine son article en répondant. quelques objections et note quʼau fond il sʼagit dʼun problème ecclésiologique.