bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cross-modal knowledge guided model for abstractive summarization
Authors: Wang Hong , Liu Jin , Duan Mingyang , Gong Peizhu , Wu Zhongdai , Wang Junxiang , Han Bing 
Published: July 2023

AbstractAbstractive summarization (AS) aims to generate more flexible and informative descriptions than extractive summarization. Nevertheless, it often distorts or fabricates facts in the original article. To address this problem, some existing approaches attempt to evaluate or verify factual consistency, or design models to reduce factual errors. However, most of the efforts either have limited effects or result in lower rouge scores while reducing factual errors. In other words, it is challenging to promote factual consistency while maintaining the informativeness of generated summaries. Inspired by the knowledge graph embedding technique, in this paper, we propose a novel cross-modal knowledge guided model (CKGM) for AS, which embeds a multimodal knowledge graph (MKG) combining image entity-relationship information and textual factual information (FI) into BERT to accomplish cross-modal information interaction and knowledge expansion. The pre-training method obtains rich contextual semantic information, while the knowledge graph supplements the textual information. In addition, an entity memory embedding algorithm is further proposed to improve information fusion efficiency and model training speed. We elaborately conducted ablation experiments and evaluated our model on the Visual Genome, FewRel, MSCOCO, and CNN/DailyMail datasets. Experimental results demonstrate that our model can significantly improve the FI consistency and informativeness of generated summaries.
The effect of family-based therapy on child physical abuse and neglect: a narrative systematic review
Authors: Economidis George , Pilkington Rhiannon , Lynch John , Dobbins Timothy , Shakeshaft Anthony , Powell Madeleine , Eades Anne-Marie , Falster Kathleen 
Published: July 2023

AbstractFamily-based therapy is a common front-line strategy to prevent child maltreatment in high-risk families. This review aimed to systematically assess the evidence of the effect of family-based therapy programs on child maltreatment outcomes. CINAHL, Scopus and PsycINFO were systematically searched to March 25, 2023. Outcome data were extracted for child protection reports and out-of-home care (OOHC) placements from administrative data, and parent- or child-reported maltreatment risk. 12 RCTs and two observational studies of 8,410 screened were included. All 14 studies had high risk of bias. Sample sizes ranged from 43 in an RCT to 3875 families in an observational study. In seven studies with child protection report risk estimates, five studies (3 RCTs, 2 observational) showed results in favor of the intervention (risk differences (RD) of 2.0–41.1 percentage points) and two RCTs in favor of the comparison (RD, 2.0–8.6 percentage points). In the four studies with OOHC risk estimates, three studies (2 RCTs, 1 observational) showed results in favor of the intervention (RD, 0.9–17.4 percentage points) and one observational study showed results in favor of the comparison (RD, 1.5 percentage points). Most studies had ≤ 100 participants, did not estimate main causal effects, and had high risk of bias. Thus, although family-based therapy programs may reduce child maltreatment, the high risk of bias, typically small sample sizes (> 62% of studies had sample sizes < 100), and inconsistent results across studies means it is currently unclear whether family-based therapy interventions achieve better child maltreatment outcomes, compared with usual care services.
Poverty Penalties as Human Rights Problems
Authors: Galbraith Jean , AlMarri Latifa , Bhati Lisha , Brooks Rheem , Green Zachary , Hu Margo , Irshaidat Noor 
Published: July 2023

AbstractFines and other financial sanctions are frequently imposed by criminal justice systems around the world. Yet they also raise grave concerns about economic discrimination. Unless they are perfectly scaled to defendants’ financial circumstances, they will penalize poor persons far more than rich ones—and poor defendants’ inability to pay can lead to further penalties like imprisonment or additional financial sanctions. These “poverty penalties” have received attention in domestic jurisdictions but are understudied as a global phenomenon. This Article takes up this issue and makes three contributions. First, it demonstrates that poverty penalties are prevalent in criminal justice systems around the world. Second, it shows how poverty penalties came to be overlooked in international human rights law and describes how this is starting to change. Third, the Article makes the normative case for addressing poverty penalties within human rights law and offers suggestions for how this can be achieved.
FINITE SOLVABLE TIDY GROUPS ARE DETERMINED BY HALL SUBGROUPS WITH TWO PRIMES
Authors: BEIKE NICOLAS F. , CARLETON RACHEL , COSTANZO DAVID G. , HEATH COLIN , LEWIS MARK L. , LU KAIWEN , PEARCE JAMIE D. 
Published: July 2023

AbstractIn this paper, we investigate finite solvable tidy groups. We prove that a solvable group with order divisible by at least two primes is tidy if all of its Hall subgroups that are divisible by only two primes are tidy.
Prosperity and Precarity in Imperial Russia's Long Nineteenth Century
Authors: Smith Alison K. 
Published: July 2023

AbstractThis article looks at four families living in and around the small town of Gatchina, not far from St Petersburg, Russia, in the long nineteenth century. Their family histories are recreated from archival files based in tsarist Russia's system of social estates (soslovie), supplemented by city directories, newspapers, and many other sources. Taken together, the four family histories expand our understanding of tsarist Russia's middle classes in two ways. First, they highlight the role that women played in families as economic actors and as agents of their own destiny. Second, they demonstrate the role that social mobility did and did not play in maintaining families across the long nineteenth century. In addition, they demonstrate some of the ways in which the Russian empire's experience of the nineteenth century differed from a standard Eurocentric narrative, in particular in the way that ‘archaic’ and ‘modern’ worlds existed simultaneously.
Beyond resilience: A scoping review of Indigenous survivance in the health literature
Authors: Wilbur Rachel E. , Gone Joseph P. 
Published: July 2023

AbstractHealth inequity scholars, particularly those engaged with questions of structural and systemic racism, are increasingly vocal about the limitations of “resilience.” This is true for Indigenous health scholars, who have pushed back against resilience as a descriptor of modern Indigeneity and who are increasingly using the term survivance. Given the growing frequency of survivance in relation to health, we performed a scoping review to understand how survivance is being applied in health scholarship, with a particular interest in its relationship to resilience. Results from 32 papers indicate that health scholars are employing survivance in relation to narrative, temporality, community, decolonization, and sovereignty, with varying degrees of adherence to the term’s original conception. Overwhelmingly, authors employed survivance in relation to historical trauma, leading us to propose the analogy: as resilience is to trauma, so survivance is to historical trauma. There may be value in further operationalizing survivance for health research and practice through the development of a unified definition and measurement tool, ensuring comparability across studies and supporting future strengths-based Indigenous health research and practice.
Perspectives in preparedness of family caregivers of patients with cancer providing end-of-life care in the home: A narrative review of qualitative studies
Authors: Ongko Emily , Philip Jennifer , Zomerdijk Nienke 
Published: July 2023

AbstractBackgroundMany patients with advanced cancer identify home as being their preferred place of death. A critical component in achieving a home death is the support of family members, who often take on responsibilities for which they feel insufficiently prepared with subsequent impacts upon their health and well-being.ObjectivesThis study sought to review existing qualitative literature on family carers’ experiences in providing end-of-life care at home for patients with advanced cancer, with an emphasis on exploring factors that influence how prepared they feel for their role.MethodsA narrative review was chosen to provide an overview and analysis of qualitative findings. MEDLINE, PubMed, PsychINFO, and EMBASE databases were searched with the following search terms: “Cancer,” “Caregiver,” “End of Life Care,” “Home,” and “Qualitative.” Inclusion criteria were as follows: English language, empirical studies, adult carers, and articles published between 2011 and 2021. Data were abstracted, and study quality was assessed using the Critical Appraisal Skills Programme checklist for qualitative research.ResultsFourteen relevant articles were included. Three overarching themes reflecting the factors influencing family preparedness for their role were identified: “motivations for providing care,” “interactions with health-care professionals,” and “changes during the caring process.”Significance of resultsInadequate preparation of family carers is apparent with regard to their role in providing end-of-life care at home for patients with advanced cancer. There is a need for health-care workers to more effectively identify the information and support needs of families, and utilize evidence-based strategies that have emerged to address these needs.
What can cause cancer patients to attempt suicide? Thiamine deficiency mimicking the symptoms of major depressive disorder
Authors: Ishida Mayumi , Sato Sho , Sato Izumi , Yoshioka Akira , Uchida Nozomu , Mizunuma Naoki , Hasegawa Kosei , Onishi Hideki 
Published: July 2023

AbstractObjectivesThiamine deficiency (TD) presents with various physical and psychiatric symptoms, but no cases with depression-like symptoms have been reported.MethodsWe report a patient with cancer who appeared to attempt suicide as a consequence of depressive mood likely related to TD.ResultsThe patient was a 58-year-old woman diagnosed with recurrent endometrial cancer, with lung metastasis and pelvic dissemination. The patient apparently attempted suicide was referred to the psycho-oncology department.
At the time of the examination, major depressive disorder was suspected based on her mental symptoms, but when thiamine was administered intravenously in response to her poor dietary intake, her palpitations, dyspnea, anorexia, and insomnia improved, and her suicidal ideation disappeared at her reexamination 1 hour later after thiamine administration.Significance of resultsIt is likely that the observed palpitations, dyspnea, anorexia, and insomnia, as well as the severe depression and the attempted suicide, which were thought to be physical symptoms associated with depression, were actually related to TD. Suicidal ideation and attempted suicide are conspicuous as psychiatric symptoms. However, in such cases, rather than simply starting treatment for depression, it is necessary to consider reversible TD as a cause of these symptoms and perform differential diagnosis to confirm the physical illness.
A novel RIP1-mediated canonical WNT signaling pathway that promotes colorectal cancer metastasis via β -catenin stabilization-induced EMT
Authors: Kang A-Ram , Kim Jung-Lim , Kim YoungHa , Kang Sanghee , Oh Sang-Cheul , Park Jong Kuk 
Published: July 2023

AbstractRIP1 (receptor-interacting protein kinase 1) is an important component of TNF-α signaling that contributes to various pathological effects. Here, we revealed new potential roles of RIP1 in controlling WNT/β-catenin canonical signaling to enhance metastasis of colorectal cancer (CRC). First, we showed that WNT3A treatment sequentially increased the expression of RIP1 and β-catenin. Immunohistochemical analyses of human CRC tissue arrays consisting of normal, primary, and metastatic cancers indicated that elevated RIP1 expression might be related to β-catenin expression, carcinogenesis, and metastasis. Intravenous injection of RIP1 over-expressed CRC cells into mice has demonstrated that RIP1 may promote metastasis. Immunoprecipitation (IP) results indicated that WNT3A treatment induces direct binding between RIP1 and β-catenin, and that this stabilizes the β-catenin protein in a manner that depends on the regulation of RIP1 ubiquitination via downregulation of the E3 ligase, cIAP1/2. Elimination of cIAP1/2 expression and inhibition of its ubiquitinase activity enhance WNT3A-induced RIP1 and β-catenin protein expression and binding, which stimulates endothelial-mesenchymal transition (EMT) induction to enhance the migration and invasion of CRC cells in vitro. The results of the in vitro binding assay and IP of exogenous RIP1-containing CRC cells additionally verified the direct binding of RIP1 and β-catenin. RIP1 expression can destroy the β-catenin–β-TrCP complex. Taken together, these results suggest a novel EMT-enhancing role of RIP1 in the WNT pathway and suggest a new canonical WNT3A–RIP1–β-catenin pathway that contributes to CRC malignancy by promoting EMT.
PME-1 sensitizes glioblastoma cells to oxidative stress-induced cell death by attenuating PP2A-B55α-mediated inactivation of MAPKAPK2-RIPK1 signaling
Authors: Guffens Liesbeth , Derua Rita , Janssens Veerle 
Published: July 2023

AbstractGlioblastoma (GBM) is the most common primary brain tumor in adults. Current standard therapy is surgery followed by radiotherapy, with concurrent and adjuvant temozolomide chemotherapy. GBM is characterized by almost uniformly fatal outcomes, highlighting the unmet clinical need for more efficient, biomarker-guided treatments. Protein phosphatase methylesterase-1 (PME-1), a regulator of the tumor suppressive phosphatase PP2A, promotes PP2A demethylation and inactivation, and is overexpressed in 44% of GBM, associated with increased tumor grade and cellular proliferation. Here, we aimed to investigate how reactive oxygen species (ROS), a frequent by-product of radiotherapy and temozolomide chemotherapy, regulate PP2A function via its methylesterase PME-1, and how PME-1 overexpression impacts the response of GBM cells to oxidative stress. We found that in two glioblastoma cell lines, U87MG and U251MG, expression of PME-1 is positively correlated with the sensitivity of the cells to H2O2 or t-BHP-induced oxidative stress. Experiments using the irreversible pharmacologic PME-1 inhibitor, AMZ30, and different PME-1 mutants, revealed that the methylesterase function, the PP2A binding capacity, and the nuclear localization of PME-1 are all important for the sensitizing effect of PME-1 expression. Furthermore, we identified increased nuclear localization of the PP2A-B55α subunit, increased binding of PP2A-B55α to PME-1, and increased B55α-bound PP2A-C demethylation upon oxidative stress. Lastly, we uncovered increased stress-induced phosphorylation and activity of MAPKAPK2 and RIPK1 in PME-1 overexpressing U87MG cells, which caused the observed sensitization to t-BHP treatment. Our data reveal a novel role for PME-1 in oxidative stress-induced GBM cell death, regulating nuclear PP2A-B55α activity and MAPKAPK2-RIPK1 signaling. Patients with GBM tumors overexpressing PME-1, although having a worse prognosis due to increased cellular proliferation of the tumor, could actually be more responsive to oxidative stress-inducing therapies.
Ion selectivity and rotor coupling of the Vibrio flagellar sodium-driven stator unit
Authors: Hu Haidai , Popp Philipp F. , Santiveri Mònica , Roa-Eguiara Aritz , Yan Yumeng , Martin Freddie J. O. , Liu Zheyi , Wadhwa Navish , Wang Yong , Erhardt Marc , Taylor Nicholas M. I. 
Published: July 2023

AbstractBacteria swim using a flagellar motor that is powered by stator units. Vibrio spp. are highly motile bacteria responsible for various human diseases, the polar flagella of which are exclusively driven by sodium-dependent stator units (PomAB). However, how ion selectivity is attained, how ion transport triggers the directional rotation of the stator unit, and how the stator unit is incorporated into the flagellar rotor remained largely unclear. Here, we have determined by cryo-electron microscopy the structure of Vibrio PomAB. The electrostatic potential map uncovers sodium binding sites, which together with functional experiments and molecular dynamics simulations, reveal a mechanism for ion translocation and selectivity. Bulky hydrophobic residues from PomA prime PomA for clockwise rotation. We propose that a dynamic helical motif in PomA regulates the distance between PomA subunit cytoplasmic domains, stator unit activation, and torque transmission. Together, our study provides mechanistic insights for understanding ion selectivity and rotor incorporation of the stator unit of the bacterial flagellum.
Enrichment and sensing tumor cells by embedded immunomodulatory DNA hydrogel to inhibit postoperative tumor recurrence
Authors: Wang Danyu , Liu Jingwen , Duan Jie , Yi Hua , Liu Junjie , Song Haiwei , Zhang Zhenzhong , Shi Jinjin , Zhang Kaixiang 
Published: July 2023

AbstractPostoperative tumor recurrence and metastases often lead to cancer treatment failure. Here, we develop a local embedded photodynamic immunomodulatory DNA hydrogel for early warning and inhibition of postoperative tumor recurrence. The DNA hydrogel contains PDL1 aptamers that capture and enrich in situ relapsed tumor cells, increasing local ATP concentration to provide a timely warning signal. When a positive signal is detected, local laser irradiation is performed to trigger photodynamic therapy to kill captured tumor cells and release tumor-associated antigens (TAA). In addition, reactive oxygen species break DNA strands in the hydrogel to release encoded PDL1 aptamer and CpG, which together with TAA promote sufficient systemic antitumor immunotherapy. In a murine model where tumor cells are injected at the surgical site to mimic tumor recurrence, we find that the hydrogel system enables timely detection of tumor recurrence by enriching relapsed tumor cells to increase local ATP concentrations. As a result, a significant inhibitory effect of approximately 88.1% on recurrent tumors and effectively suppressing metastasis, offering a promising avenue for timely and effective treatment of postoperative tumor recurrence.
Rapid prototyping of high-resolution large format microfluidic device through maskless image guided in-situ photopolymerization
Authors: Paul Ratul , Zhao Yuwen , Coster Declan , Qin Xiaochen , Islam Khayrul , Wu Yue , Liu Yaling 
Published: July 2023

AbstractMicrofluidic devices have found extensive applications in mechanical, biomedical, chemical, and materials research. However, the high initial cost, low resolution, inferior feature fidelity, poor repeatability, rough surface finish, and long turn-around time of traditional prototyping methods limit their wider adoption. In this study, a strategic approach to a deterministic fabrication process based on in-situ image analysis and intermittent flow control called image-guided in-situ maskless lithography (IGIs-ML), has been proposed to overcome these challenges. By using dynamic image analysis and integrated flow control, IGIs-ML provides superior repeatability and fidelity of densely packed features across a large area and multiple devices. This general and robust approach enables the fabrication of a wide variety of microfluidic devices and resolves critical proximity effect and size limitations in rapid prototyping. The affordability and reliability of IGIs-ML make it a powerful tool for exploring the design space beyond the capabilities of traditional rapid prototyping.
MSBooster: improving peptide identification rates using deep learning-based features
Authors: Yang Kevin L. , Yu Fengchao , Teo Guo Ci , Li Kai , Demichev Vadim , Ralser Markus , Nesvizhskii Alexey I. 
Published: July 2023

AbstractPeptide identification in liquid chromatography-tandem mass spectrometry (LC-MS/MS) experiments relies on computational algorithms for matching acquired MS/MS spectra against sequences of candidate peptides using database search tools, such as MSFragger. Here, we present a new tool, MSBooster, for rescoring peptide-to-spectrum matches using additional features incorporating deep learning-based predictions of peptide properties, such as LC retention time, ion mobility, and MS/MS spectra. We demonstrate the utility of MSBooster, in tandem with MSFragger and Percolator, in several different workflows, including nonspecific searches (immunopeptidomics), direct identification of peptides from data independent acquisition data, single-cell proteomics, and data generated on an ion mobility separation-enabled timsTOF MS platform. MSBooster is fast, robust, and fully integrated into the widely used FragPipe computational platform.
The intensities of canonical senescence biomarkers integrate the duration of cell-cycle withdrawal
Authors: Ashraf Humza M. , Fernandez Brianna , Spencer Sabrina L. 
Published: July 2023

AbstractSenescence, a state of irreversible cell-cycle withdrawal, is difficult to distinguish from quiescence, a state of reversible cell-cycle withdrawal. This difficulty arises because quiescent and senescent cells are defined by overlapping biomarkers, raising the question of whether these states are truly distinct. To address this, we use single-cell time-lapse imaging to distinguish slow-cycling cells that spend long periods in quiescence from cells that never cycle after recovery from senescence-inducing treatments, followed by staining for various senescence biomarkers. We find that the staining intensity of multiple senescence biomarkers is graded rather than binary and reflects the duration of cell-cycle withdrawal, rather than senescence per se. Together, our data show that quiescent and apparent senescent cells are nearly molecularly indistinguishable from each other at a snapshot in time. This suggests that cell-cycle withdrawal itself is graded rather than binary, where the intensities of senescence biomarkers integrate the duration of past cell-cycle withdrawal.
The Gram-positive bacterium Romboutsia ilealis harbors a polysaccharide synthase that can produce (1,3;1,4)-β-d-glucans
Authors: Chang Shu-Chieh , Kao Mu-Rong , Saldivar Rebecka Karmakar , Díaz-Moreno Sara M. , Xing Xiaohui , Furlanetto Valentina , Yayo Johannes , Divne Christina , Vilaplana Francisco , Abbott D. Wade , Hsieh Yves S. Y. 
Published: July 2023

Abstract(1,3;1,4)-β-d-Glucans are widely distributed in the cell walls of grasses (family Poaceae) and closely related families, as well as some other vascular plants. Additionally, they have been found in other organisms, including fungi, lichens, brown algae, charophycean green algae, and the bacterium Sinorhizobium meliloti. Only three members of the Cellulose Synthase-Like (CSL) genes in the families CSLF, CSLH, and CSLJ are implicated in (1,3;1,4)-β-d-glucan biosynthesis in grasses. Little is known about the enzymes responsible for synthesizing (1,3;1,4)-β-d-glucans outside the grasses. In the present study, we report the presence of (1,3;1,4)-β-d-glucans in the exopolysaccharides of the Gram-positive bacterium Romboutsia ilealis CRIBT. We also report that RiGT2 is the candidate gene of R. ilealis that encodes (1,3;1,4)-β-d-glucan synthase. RiGT2 has conserved glycosyltransferase family 2 (GT2) motifs, including D, D, D, QXXRW, and a C-terminal PilZ domain that resembles the C-terminal domain of bacteria cellulose synthase, BcsA. Using a direct gain-of-function approach, we insert RiGT2 into Saccharomyces cerevisiae, and (1,3;1,4)-β-d-glucans are produced with structures similar to those of the (1,3;1,4)-β-d-glucans of the lichen Cetraria islandica. Phylogenetic analysis reveals that putative (1,3;1,4)-β-d-glucan synthase candidate genes in several other bacterial species support the finding of (1,3;1,4)-β-d-glucans in these species.