bluuebunny/crossref_metadata_2025_split huggingface dataset:
Early Prediction of Sepsis in Intensive Care Patients Using the Machine Learning Algorithm NAVOY® Sepsis, a Prospective Randomized Clinical Validation Study
Authors: Persson Inger , Macura Andreas , Becedas David , Sjövall Fredrik 
Published: February 2023

Abstract
Background

The objective of this study was to prospectively validate, in an ICU setting, the prognostic accuracy of the machine learning sepsis prediction algorithm NAVOY® Sepsis. The algorithm uses, on an hourly basis, 4 hours of input for up to 20 routinely collected vital parameters, blood gas values, and lab values, to predict the development of sepsis in the coming hours.

Methods

Patients aged 18 years or older admitted to the ICU at Skåne University Hospital Malmö from December 2020 to September 2021 were recruited in the study, with all available ICU beds monitored with the algorithm NAVOY® Sepsis. A total of 304 patients were randomized into one of two groups: Algorithm group with active sepsis alerts, or Standard of care. NAVOY® Sepsis made silent predictions in the Standard of care group, in order to evaluate its performance without disturbing the outcome. The study was blinded, i.e., study personnel did not know to which group patients were randomized. The healthcare provider followed standard practices in assessing possible development of sepsis and intervening accordingly. The patients were followed-up in the study until ICU discharge.

Results

In this study, NAVOY® Sepsis could predict the development of sepsis, according to the Sepsis-3 criteria, three hours before sepsis onset with high performance: accuracy 0.79; sensitivity 0.80; and specificity 0.78. The primary analysis was performed on all patients from the Standard of care group that had enough data for the algorithm to make a prediction 3 hours before sepsis onset (n = 85).

Conclusions

The accuracy, sensitivity, and specificity were all high, validating the prognostic accuracy of NAVOY® Sepsis in an ICU setting, including Covid-19 patients.

Trial registration

Registered at ClinicalTrials.gov September 30, 2020; NCT04570618.
A concept of computerized accelerometers
Authors: Xu Peiliang 
Published: February 2023

Abstract
Accelerometers are supposed to be physical instruments for measuring the acceleration of a moving object. Although huge technological advance is made in hardware of accelerometers over more than one century, accelerometers have been persistently designed and fabricated mechanically under the framework of forward problems of damped mass-spring systems. However, accelerometers are essentially inverse ill-posed source problems from the mathematical point of view, implying that small measurement errors of equivalent displacements are inherently amplified significantly such that accelerations output from accelerometers can become extremely noisy, numerically incorrect and physically meaningless in the case of high sampling rates. The ill-posedness of accelerometers cannot be rigorously solved mechanically but is always implicitly circumvented approximately. As a result, accelerometers theoretically can only produce approximate outputs of acceleration. Here we present the concept of computerized accelerometers in distinguishment of mechanical ones by applying regularization to compute accelerations from equivalent displacements. The acceleration is rigorously reconstructed mathematically as a solution to the inverse ill-posed source problem of acceleration. The concept of computerized accelerometers theoretically warrants precise measurement of acceleration without approximation, is valid for nonlinear damping as well and provides a turning point for accelerometers from a mechanical approximation to a fully rigorous computerized instrument.
WITHDRAWN: Keratinized epithelium, an indication of provisional matrix formation and early implant placement in the aesthetic area: An animal study
Authors: ren chengyan , chen weihui , chen jiangpin , mao chuanqing , liao caiyu , liu jianan 
Published: February 2023

Abstract
Objective: This study aimed to determine the relationship between provisional matrix (PM) and keratinized epithelium (KE) and to treat KE as an indication for early implant placement according to its healing process. In addition, a healing pattern when an implant was inserted into the PM was illustrated.
Material and Methods: Male ICR mice (n=6) were sacrificed at d1, d2, d3, d4 and d6 after left upper incisor extraction. The extraction sockets were subjected to clinical, histological and immunohistochemistry evaluation and statistical analysis. Afterward, an implant was inserted into the PM according to previous result.
Result: Sockets were occupied mainly by PM with the highest expression of osteocalcin (OC, P<0.05) and relatively high levels of CD34 and Runx2 when KE reached its fusion on sockets. The coverage of KE was positively correlated with OC and Runx2 expression (P<0.05). The PM surrounding the implant surface continued to heal, which made the process of osteointegration faster when compared to staged implant placement in previous studies.
Conclusion: The fusion of KE on the extraction socket, dominated by high bioactive PM, could be treated as an indication of early implant placement.
Clinical Relevance: This indication can be applied in clinical situation. The sufficient KE and formation of PM are helpful for primary wound closure and quicker osteointegration.
Evaluation of maternal anxiety and depression levels in pregnancies with fetal anomalies
Authors: Koc Bergen Laleli , Ersak Duygu Tugrul , Elmas Burak , Can Kazım Cihan , Kara Ozgur , Sahin Dilek 
Published: February 2023

Abstract
Purpose
This study aimed to document depression and anxiety levels in pregnant women with intrauterine fetal anomalies based on objective measurement inventories, raise awareness of this issue and provide the necessary support to patients.
Methods
Forty pregnant women between the ages of 18–41 who were diagnosed with a major fetal anomaly, and decided their pregnancy to continue were included in the study group. Forty pregnant women with a healthy fetus and gestational week and maternal age matched with the study group were included as the control group. The Beck Depression Inventory (BDI) and the Spielberger State-Trait Anxiety Inventory (STAI) were applied to pregnant women.
Results
Anxiety and depression levels were compared between pregnant women diagnosed with an intrauterine fetal anomaly and the control group. The mean BDI score was statistically significant in the study group (P = 0.008). In the STAI scoring, the mean state anxiety level (P<0.001) and the mean trait anxiety score was (P = 0.001) and found to be statistically significant in the study group.
Conclusion
The depressive symptom scores and the state and trait anxiety levels of pregnant women with the intrauterine fetal anomaly, increased compared to the healthy pregnant women. These women should be provided with professional psychological support and necessary medical assistance during this difficult period.
Curcumin Loaded Mesoporous Silica Nanoparticles: A Novel Therapeutic Strategy for Neurochemical Disorders
Authors: Pathak Adarsh Kumar , Singh Bhuwanendra 
Published: February 2023

Abstract
Background: Curcumin is extracted from the rhizomes of Curcuma longa and is an ideal candidate to treat neurological disorders. We aim to design a molecule containing curcumin-loaded mesoporous silica nanoparticles for brain delivery. Curcumin-loaded mesoporous silica nanoparticles are synthesized and evaluated via physiochemical properties, Fourier transform infrared analysis, ultraviolet, scanning electron microscopy, and X-ray diffraction analysis.
Results: Curcumin-loaded mesoporous silica nanoparticles outperformed standard in terms of physiochemical properties. Fourier transform infrared analysis confirms curcumin's successful incorporation into the mesoporous silica cells, where the quaternary carbon has an absorption band at 1521.22 cm-1 and CH2 at 2858.4 cm-1. Also, the drug loading was confirmed through scanning electron microscopy and particle size determination techniques because the sizes of unloaded and loaded particles are different from each other. So, the result is clear evidence of the loading of curcumin onto the prepared nanoparticle. X-ray diffraction analysis confirms drug entrapment within the silica nanoparticle: there is no additive peak of the drug in the final hexagonal channel of the loaded nanoparticle.
Conclusions: Curcumin-loaded mesoporous silica nanoparticles for brain delivery were successfully synthesized, and afterward they were able to treating neurological disorders.
18 F-FDG-PET/CT based deep learning model for fully automated prediction of pathological grading for pancreatic ductal adenocarcinoma before surgery
Authors: Zhang Gong , Bao Chengkai , Liu Yanzhe , Wang Zizheng , Du Lei , Zhang Yue , Wang Fei , Xu Baixuan , Zhou S. Kevin , Liu Rong 
Published: February 2023

Abstract
Background ：The determination of pathological grading has a guiding significance for the treatment of pancreatic ductal adenocarcinoma（PDAC）patients. However, there is a lack of an accurate and safe method to obtain pathological grading before surgery. The aim of this study is to develop a deep learning（DL）model based on 18F-FDG-PET/CT for a fully automatic prediction of preoperative pathological grading of pancreatic cancer.
Results ：A total of 370 PDAC patients from January 2016 to September 2021 were collected retrospectively. All patients underwent 18F-FDG-PET/CT examination before surgery and obtained pathological results after surgery. A DL model for pancreatic cancer lesion segmentation was first developed using 100 of these cases and applied to the remaining cases to obtain lesion regions. After that, all patients were divided into training set, validation set and test set according to the ratio of 5:1:1. A predictive model of pancreatic cancer pathological grade was developed using the features computed from the lesion regions obtained by the lesion segmentation model and key clinical characteristics of the patients. Finally, the stability of the model was verified by 7-fold cross-validation.The Dice score of the developed PET/CT based tumour segmentation model for PDAC was 0.89. The area under curve (AUC) of the PET/CT-based DL model developed on the basis of the segmentation model was 0.74, with an accuracy, sensitivity, and specificity of 0.72, 0.73, and 0.72, respectively. After integrating key clinical data, the AUC of the model improved to 0.77, with its accuracy, sensitivity, and specificity boosted to 0.75, 0.77, and 0.73, respectively.
Conclusion ：To the best of our knowledge, this is the first deep learning model to end-to-end predict the pathological grading of PDAC in a fully automatic manner, which is expected to improve clinical decision making.
Sonographic evaluation of axillary lymph node status in newly diagnosed breast cancer patients: A prospective study
Authors: Dawood Shawnam Nasih , Jamal Aska Faruq 
Published: February 2023

Abstract
Background: Accurate assessment of axillary lymph node status is important for breast cancer staging and treatment. Sonography can detect metastatic lymph nodes with varying degrees of sensitivity and specificity, while its routine use in the preoperative assessment of axillary lymph nodes remains controversial. The aim of this study was to assess the diagnostic accuracy of pretreatment axillary sonography in our clinical setting and to determine whether sonographic evaluation of the axilla as a tool for regional staging of breast cancer should be performed routinely in all cases.
Methods: The study recruited 185 women with histologically confirmed breast cancer from September 2021 to December 2022. Axillary ultrasound was performed on all patients to assess lymph node status using predetermined criteria. The ultrasound findings were compared to the histopathology results.
Results: Axillary sonography had 94.1% sensitivity, 87.7% specificity, 95.5% positive predictive value, 96.0% negative predictive value, and 92.4% accuracy in detecting metastatic lymph nodes in newly diagnosed breast cancer patients. In comparison to benign axillae, malignant axillae were significantly more likely to meet the lymph node criteria for "lobulated or irregular margin," "round or irregular shape," "focal or eccentric cortical thickening ≥3 mm," "totally replaced cortex," and "non-hilar blood flow" (p < 0.001).
Conclusions: Pretreatment sonography of the axilla had a high accuracy rate and a good outcome in the evaluation of lymph node status in newly diagnosed breast cancer patients, and it should be performed routinely in all cases.
Trial registration: Not applicable
The influence of the preoperative albumin to alkaline phosphatase ratio on OS in postradical colorectal cancer and the construction of a nomogram prediction model
Authors: Jiang Wenliang , Li Zhenchi , Xun Feng , Xia Yong , Hu Haoran , Liu Yujun , Zhao Zhibin , Wang Honggang 
Published: February 2023

Abstract
Objective
The albumin to alkaline phosphatase ratio (AAPR) is a newly developed blood biomarker that has been reported to have prognostic value in several types of cancers. The aim of this study was to investigate the predictive value of AAPR in overall survival after radical colon cancer surgery in patients with stage I-III colorectal cancer (CRC).
Methods
The clinical data of 221 eligible patients with stage I ~ III CRC were retrospectively analysed. A series of survival analyses were performed to assess the prognostic value of AAPR. Univariate and multifactorial Cox analyses were performed to identify independent risk factors. Columnar graph prediction models were further constructed based on independent risk factors such as AAPR, and their predictive properties were validated.
Results
The optimal cutoff value of preoperative AAPR for postoperative OS in patients undergoing laparoscopic radical CRC was 0.495 as shown by univariate and multifactorial Cox regression analysis. The factors of age ≤ 65 years, TNM stage I-II, tumour grading (high/medium differentiation), CEA ≤ 5 and AAPR ≥ 0.495 were associated with better OS (P < 0.05).
Conclusions
Preoperative AAPR level was a good predictor of postoperative survival in patients undergoing laparoscopic radical CRC surgery, and AAPR < 0.495 was an independent risk factor for decreased postoperative OS.
Study of process of removing burrs from group holes in TC4 titanium alloy plate by non-synchronous rotation
Authors: Jiao Anyuan , liu Jie , Yang Ziyu , Zhang Yulong , Zhang Jialong 
Published: February 2023

Abstract
It is very important to remove the entrance and exit burrs of group holes in TC4 titanium alloy plate. In order to improve the efficiency, a novel method of removing burrs by non-synchronous rotation of opposite rotating magnetic pole is proposed by magnetic abrasive finishing (MAF). The influence of force change on the abrasive particles, magnetic field intensity and magnetic field gradient on the burrs removal under the relative rotation angle were studied. Meanwhile, the parameters are optimized through the experiment of non-synchronous rotation, which are magnetic pole speed, abrasive particle size and abrasive filling amount by response surface methodology (RSM). By using the method of non-synchronous rotation, the constant magnetic field distribution is improved, and the renewal of the cutting edge of magnetic abrasive particles is accelerated. Based on the investigation of rotating grinding of opposite four magnetic poles, when the rotation speed of magnetic pole I is 600r/min, the best process parameters are obtained as follows: the rotating speed of magnetic pole II is 800 r/min, and the particle size is 250 µm, abrasive filling amount is 30g. The exit burrs height decreased from 200.4 µm to 14.5 µm by 92.7%, and the entrance burrs height decreased from 180.5 µm to 10.5 µm by 94.2%. The analysis of the experiment results shows that the relative speed of the magnetic pole is faster, the splashing of abrasive particles is easier, and the lower the grinding efficiency. On the contrary, if the relative speed is smaller, the burrs removal will be more difficult. However, the impact of size of abrasive particles and the amount of abrasive filling on the burrs height is insignificant. In the process of non-synchronous rotation grinding, the entrance and exit burrs are removed at the same time, so the removal amount is greatly increased, and the grinding efficiency is improved. According to numerical simulation and experimental analysis, non-synchronous rotation grinding technology is verified, which provides a theoretical basis for the burrs removal technology.
Electric Vehicle in Smart Grid Integrated Photovoltaic Environment with Storage System
Authors: MANISSEGARANE SUVEDHA , RAJAN CHRISTOBER ASIR 
Published: February 2023

Abstract
This research introduces a novel hybrid sliding mode controller integrated with the artificial neural network (SMC-ANN) used for purpose of real power exchange using Intelligence Power Management System (IPMS). This paper's purpose is to explore the transient and steady state voltage, transient current, transient power of EV, along with the EV torque and EV speed. In giving a nonlinear signal that simulates the network to "glide" across a cross-section of its normal behavior, sliding mode control is a nonlinear control strategy that affects a dynamic of a nonlinear system. The setup consists of utility grid, integrated Photovoltaic source (PV) energy with Battery Storage System (BSS). A high gain DC/DC boost converter is implemented to interface BSS to the DC-bus. The Power Conditioning System receives the DC output voltage from the PV panel (PCS). These converters' bidirectional nature offers the benefit of power transfer between storage systems, loads, and PV systems. The results obtained using newly developed algorithm is compared with the conventional sliding mode controller (SMC) and it is seen that the a newly developed algorithm produced better outcomes than the conventional one. Simulation is performed using MATLAB software.
National Survey on the Availability of Oncology Palliative Care Services at Tertiary General and Cancer Hospitals in China
Authors: Li XiaoMei , Wang Xin Shelley , Huang Haili , Liu Miao , Wu YiNan , Qiu JiaoJiao , Zhang Boran , Hui David 
Published: February 2023

Abstract
Purpose: The nationwide survey studied the level of palliative care (PC) access for Chinese patients with cancer among cancer care providers either in tertiary general hospitals or cancer hospitals in China.
Methods:Using a probability-proportionate-to-size method, local tertiary general hospitals with oncology departments were identified to match cancer hospitals. A PC program leader or a designee per hospital reported the PC services, including staffing, inpatient and outpatient services, education, and research, based on questions adapted from a previous national survey on PC. The primary outcome was availability of a PC service.
Results: From responders, most hospitals reported that some type of PC service was available (84.3% of tertiary general hospitals, 82.8% of cancer hospitals), although named as “comprehensive cancer care”, “pain and symptom management” or “supportive care”. However, cancer hospitals were significantly more likely than tertiary general hospitals to have a PC department or specialist (34.1% compared with 15.5%, p<0.001). The most popular services were pain consultation (>92%), symptom management (>77%), comprehensive care plans (~60%), obtaining advanced directives and do-not-resuscitate (DNR) orders (~45%), referrals to hospice (>32%), and psychiatric assessment (>25%). Cancer hospitals were also more likely than tertiary general hospitals to report having inpatient beds for PC (46.3% compared with 30.5%; p=0.010), outpatient PC clinics (28.0% compared with 16.8%; p=0.029), educational programs (18.2% compared with 9.0%, p=0.014), and research programs (17.2% compared with 9.3%, p<0.001).
Conclusion: Cancer hospitals have greater availability of PC than do tertiary general hospitals in China. Our findings highlight opportunities to further increase the PC capacity in Chinese hospitals.
The Examination of Fetal Myocardium and Maternal and Fetal Features of Pregnancy Complicated by Gestational Diabetes Mellitus
Authors: Pál Zoltán , Kádas Zsófia , Németh Gábor , Surányi Andrea 
Published: February 2023

Abstract
Purpose:
We examined the morphological factors affecting the growing foetus’ heart, the fetal and maternal relations of pregnancies complicated by diabetes mellitus. We seaked the severity of myocardium hyperplasia is in correlation with infant respiratory distress syndrome and cardiac failure. Our study was a prospective case- control study of pregnancies complicated by diabetes mellitus produce fetal myocardium hyperplasia.
Methods:
Two ultrasound examinations were carried out on 84 pregnant women, in accordance with the selection criteria (different types of diabetes mellitus and controll cases).
The first ultrasound examination was carried out between the 24-28th weeks, the second between the 33-38th weeks of pregnancy. During the examinations we measured and averaged the fetal sizes, the estimated fetal weight, the quantity of amniotic fluid and the thickness of the ventricles and interventricular septum. Besides, we collected data from pregnant women in connection with the symptoms of diabetes mellitus, plus followed the outcome of these pregnancies. We compared these data against the our control group and a literature reference group.
Results:
Regarding the fetal myocardium and the interventricular septum, significantly higher values were registered compared to the control group, and 21% of the infants are macrosomic, 16% of them were born with intrauterine growth restriction.
Conclusions:
Based on the examinations we concluded that more complications occurred to foetuses and infants of obese pregnant women and those with diabetes mellitus than in the control groups. Thus, following the fetal myocardium’s parameters in the perinatal outcome of the mother’s glucose system’s discrepancies can be a well-applicable filtering method.