bluuebunny/crossref_metadata_2025_split huggingface dataset:
The impact of increasing saline flush volume to reduce the amount of residual air in the delivery system of aortic prostheses – a randomized controlled trial
Authors: Szentiványi András , Borzsák Sarolta , Vecsey-Nagy Milán , Süvegh András , Hüttl Artúr , Fontanini Daniele Mariastefano , Szeberin Zoltán , Csobay-Novák Csaba 
Published: June 2023

Abstract
Air embolism during thoracic endovascular aortic repair (TEVAR) is associated to an incomplete deairing of the delivery system (DS) despite the saline lavage recommended by the instructions for use (IFU). As the DSs are identical, endovascular aortic repair (EVAR) can be used to examine the effectiveness of deairing maneuvers. We aimed to evaluate if a more complete deairing can be achieved with increasing the flush volume. EVAR patients were randomised according to flushing volume (Group A:1xIFU & Group B: 4xIFU). Air trapped in the aneurysm sac was quantified on pre-discharge CTA. 30 patients were enrolled and equally distributed between the two groups. There were no differences in any demographic or anatomical factors. Presence of air was less frequent in Group A than in Group B (7 (47%) vs. 13 (87%), p = .02), volume of air was less in Group A compared to Group B (103.5 ± 210.4 vs. 175.5 ± 175.0 mm3, p = .04). Volume of trapped air was higher with Anaconda graft type (p = .025). Increased flushing volume is associated with more trapped air, thus following the IFU might be associated with smaller risk of air embolization. Significant differences were identified between devices regarding the amount of trapped air.
Preoperative Chemoradiotherapy in Older Patients with Rectal Cancer Guided by Comprehensive Geriatric Assessment within a Multidisciplinary Team—A Multicenter Phase II Trial
Authors: Liu Wen-Yang , Tang Yuan , Li Ning , Tang Yu , Cheng Yun-Jie , Yang Lin , Fang Hui , Lu Ning-Ning , Qi Shu-Nan , Chen Bo , Wang Shu-Lian , Song Yong-Wen , Liu Yue-Ping , Li Ye-Xiong , Liu Zheng , Liang Jian-Wei , Pei Wei , Wang Xi-Shan , Zhang Hai-Zeng , Wang Jun , Zhou Hai-Tao , Jin Jing 
Published: June 2023

Abstract
Background and purpose: The purpose of this study was to evaluate the safety and efficacy of preoperative concurrent chemoradiotherapy (preCRT) for locally advanced rectal cancer in older people who were classified as “fit” by comprehensive geriatric assessment (CGA).
Methods: A single-arm, multicenter, phase II trial was designed. Patients were eligible for this study if they were aged 70 years or above and met the standards of “fit” (SIOG1) as evaluated by CGA and of the locally advanced risk category. The primary endpoint was 2-year disease-free survival (DFS). Patients were scheduled to receive preCRT (50 Gy) with raltitrexed (3 mg/m2 on days 1 and 22).
Results: One hundred and nine patients were evaluated by CGA, of whom eighty-six, eleven and twelve were classified into the fit, intermediate and frail category, Sixty-eight fit patients were enrolled. Sixty-four patients (94.1%) finished radiotherapy without dose reduction. Fifty-four (79.3%) patients finished the prescribed raltitrexed therapy as planned. Serious toxicity (grade 3 or above) was observed in twenty-four patients (35.3%), and fourteen patients (20.6%) experienced nonhematological side effects. Within a median follow-up time of 36.0 months (range: 5.9-63.1 months), the 2-year overall survival (OS), cancer-specific survival (CSS) and disease-free survival (DFS) rates were 89.6% (95% CI: 82.3-96.9), 92.4% (95% CI: 85.9-98.9) and 75.6% (95% CI: 65.2-86.0), respectively. Forty-eight patients (70.6%) underwent surgery (R0 resection 95.8%, R1 resection 4.2%), the corresponding R0 resection rate among the patients with positive mesorectal fascia status was 76.6% (36/47).
Conclusion: This phase II trial suggests that preCRT is efficient with tolerable toxicities in older rectal cancer patients who were evaluated as fit based on CGA.
CD4 T lymphocyte subsets display heterogeneous susceptibility to apoptosis induced by serum from patients with systemic lupus erythematosus
Authors: Mesquita Fernanda Vieira , Ferreira Vanessa , Mesquita Danilo , Andrade Luis Eduardo Coelho 
Published: June 2023

Abstract
Background: Serum from systemic lupus erythematosus (SLE) patients has been shown to induce T-lymphocyte (TL) apoptosis. Given that different cells of the immune system display different sensitivity to apoptosis, we set to evaluate the in vitro effect of SLE serum on regulatory T-cells (Treg), Th17, Th1 and Th2 from SLE patients and healthy controls.
Methods: Peripheral blood mononuclear cells from SLE patients or normal controls were exposed to a pool of sera from SLE patients or normal controls. Annexin V was used to label cells in apoptosis or necrosis. Annexin V-labeled Treg, Th17, Th1 and Th2 cells were determined using flow cytometry.
Results: Total CD3+ and CD4+ cells from SLE patients showed higher frequency of spontaneous apoptosis/necrosis than cells from controls, whereas Th1 cells from SLE patients presented reduced spontaneous apoptosis/necrosis rate as compared with cells from controls. Total CD3+ and CD4+ cells from normal controls incubated with SLE serum presented increased frequency of apoptotic/necrotic cells as compared with cultures incubated with normal human serum (NHS) or without human serum at all. Treg cells from SLE patients were more prone to apoptosis/necrosis induced by SLE serum than Treg cells from normal individuals. Incubation with SLE serum did not increase the apoptosis/necrosis rate in Th1, Th2 or Th17 cells. Th1 and Th17 cells presented increased apoptosis rates in cultures without human serum.
Conclusion: Our findings indicate that the serum of patients with active SLE stimulates apoptosis of CD4+ T cells in general and exhibit differentiated effects on CD4+ T-cell subsets.
Anomalous Origin of Left Main Coronary Artery from the Right Sinus of Valsalva
Authors: Chua Frederick , Vongbunyong Kenny , Urgun Deniz Akay , Ghashghaei Roxana 
Published: June 2023

Abstract
Anomalous coronary arteries are rare congenital variations with cases ranging from asymptomatic to life-threatening. Given the wide variability of coronary anomalies, it is challenging to predict their clinical consequences. Here, we present the ‘malignant’ variant – interarterial course of the left coronary artery between the aorta and pulmonary trunk – given the highest risk of sudden cardiac death among the various coronary anomalies.
Learning Objectives:
1. To describe the ‘malignant’ interarterial course of the left coronary artery and its association with sudden cardiac death
2. To present the various surgical options recommended to patients with this variant
Heat Transfer Enhancement in Parallel Flow Double Pipe Heat Exchanger using Aluminum Oxide and Copper Oxide Nanofluids
Authors: Al-Ogaili Mohammed Faleh , Rava Mohammad , Rasheed Adnan Hameed , Othman Mohd Hafiz Dzarfan , Shehab Mohammed Ahmed , Alktranee Mohammed 
Published: June 2023

Abstract
This study investigates the effects of Copper oxide (CuO) and aluminum oxide (Al2O3) nanofluids with different diameter sizes and concentrations dissolved in water on a double-pipe heat exchanger (DPHE) behavior numerically. Thereby evaluating the effect of nanofluid's characteristics on heat transfer coefficient, friction factor, Reynolds number and Nusselt number. This objective was accomplished by numerically investigating (through ANSYS) and determining the effect of volume fraction and diameter of nanoparticles on heat transfer and fluid flow via a DPHE. The results showed that under ideal conditions such as 4 vol% and diameter 25 nm, Al2O3 has a better performance by 99.61% than water under 20000 Reynolds number, while CuO performance was 93.52% at the same conditions.
Recent progress in organic waste recycling materials for solar cell applications
Authors: Bautista-López José Alfonso , Díaz-Ponce Arturo , Rangel-Méndez José René , Chazaro-Ruiz Luis Felipe , Joseph-Mumanga Takawira , Olmos-Moya Patricia , Vences-Álvarez Esmeralda , Pineda-Arellano Carlos Antonio 
Published: June 2023

Abstract
Organic waste-derived solar cells (OWSC) are a classification of third-generation photovoltaic cells in which one or more of its constituents are fabricated from organic waste material. They are an inspirational complement to the conventional third-generation solar cell with the potential of revolutionizing our future approach to solar cell manufacture. This article provides a study and summary of solar cells that fall under the category of OWSC. OWSC own their merit to low cost of manufacturing and environmental friendliness. This review article reveals different organic waste raw materials, preparation-to-assembly methodologies and novel approaches to solar cell manufacturing. Ideas for the optimization of the performance of OWSC are presented. The assembly configurations and photovoltaic parameters of reported OWSC are compared in detail. An overview of the trends pertaining to the research regarding OWSC in the past decade is given. Also, advantage and disadvantage of the different solar cell technologies are discussed and possible trends are proposed. Industrial organic waste raw materials such as paper, coal and plastics are amongst the least explored and yet most attractive for solar cell fabrication. The power conversion efficiencies for the cited works are mentioned while emphasizing the products and functions of the organic waste raw materials used.
Effect of Purpureocillium lilacinum on inter-root soil microbial community and metabolism of tobacco
Authors: Zhang JiLi , Song Jia Yi , Wei Jian Yu , Qi Shi , Li Junlin , Jin Yabo , Luan Xinbo , Li Ping , Yan Jian 
Published: June 2023

Abstract
Numerous chemical pesticides have been used in agricultural production to combat crop diseases and pests. Despite ensuring certain economic advantages, they have also resulted in issues like environmental contamination, declining soil quality, and pesticide residues. Because biological control is environmentally friendly and difficult to acquire resistance to, it has been used in practice recently. We isolated the endophytic fungus Purpureocillium lilacinum from Portulaca oleracea L., which was previously found to have inhibitory effects on soil pathogens in tobacco fields. In order to explore the effects of the biocontrol agent Purpureocillium lilacinum on soil microorganisms and plant metabolism in tobacco cultivation, we combined amplicon sequencing technology and gas chromatography-mass spectrometry to carry out the analysis of soil microbial community structure and microbial-metabolite interaction network in inter-rhizosphere soil of tobacco field under different application method of P. lilacinum treatment. The findings showed that there was a trend toward less microbial diversity among inter-root microorganisms as solid-state fermentation (SSF) products of P. lilacinum increased; however, submerged fermentation (SmF) had no discernible impact on microbial diversity when compared to the direct use of SSF. Additionally, the relationship between inter-root fungi and volatile compounds of tobacco leaves was dominated by a negative correlation. The result demonstrated that P. lilacinum's antagonistic interaction in the inter-rhizosphere microbial community was dominant and valuable for biopesticide application. P. lilacinum can work more effectively on tobacco roots by using SSF products. P. lilacinum's opposition to fungal colonies may enhance the volatile chemicals in tobacco leaves.
Implementation of IoT and Blockchain in Traffic Control by using Matrix Algorithm
Authors: AHMED MANZAR , -ul-Haque Mohammad Ibrar , Ahmed Afshaar , Kamel Hesham , Radi Wafa , Amin Uzma 
Published: June 2023

Abstract
with the growing population in the entire world, especially in under develop countries, the traffic problems are arising with high ratio. The people are using cars, bikes, trains and buses to research at destination. The rush on the roads has been increased rapidly and traffic controlling issues are at worst condition. In year 2030, the traffic will be double and the resources will be almost same. The major issue is to control traffic and conjunction in future automatically. One way is to construct new roads overhead and underground bridges but it is not possible in under developing countries like Pakistan, India and Bangladesh, etc. The other solution is to implement automatic system with the combination of IoT and blockchain and sensors to address this issue. The automatic system must be intelligent to detect changes in traffic conditions and automatically change the traffic signal timings to control congestion. For this purpose, videos cameras and IoT network sensors can be used to sense the condition, position of vehicles at a traffic signal and send information to control room or change signaling time automatically for optimum performance. In this research compare different methods to resolve above issue and matrix method will be analyze to address the issue. For simulation, the matlab simulation tool will be use.
Effect of Parental Adverse Childhood Experiences on Intergenerational DNA Methylation Signatures
Authors: Mohazzab-Hosseinian Sahra , Garcia Erika , Wiemels Joseph , Marconett Crystal , Corona Karina , Howe Caitlin , Foley Helen , Lerner Deborah , Lurvey Nathana , Farzan Shohreh , Bastain Theresa , Breton Carrie 
Published: June 2023

Abstract
Adverse Childhood Experiences (ACEs) are events that occur before a child turns 18 years old that may cause trauma. In this study, the effect of cumulative ACEs experienced on human maternal DNA methylation (DNAm) was estimated while accounting for interaction with domains of ACEs in prenatal peripheral blood mononuclear cell samples from the Maternal and Developmental Risks from Environmental Stressors (MADRES) pregnancy cohort. The intergenerational transmission of ACE-associated DNAm was also explored used paired maternal and neonatal cord blood samples. Replication in buccal samples was explored in the Children’s Health Study (CHS). We used a four-level categorical indicator variable for ACEs exposure: none (0 ACEs), low (1–3 ACEs), moderate (4–6 ACEs), and high (> 6 ACEs). Effects of ACEs on maternal DNAm (N = 240) were estimated using linear models. To evaluate evidence for intergenerational transmission, mediation analysis was used. Analysis of maternal samples displayed some shared but mostly distinct effects of ACEs on DNAm across low, moderate, and high ACEs categories. CLCN7 and PTPRN2 was associated with maternal DNAm in the low ACE group and this association replicated in the CHS. ACE-associated methylation was observed in maternal and neonatal profiles in the COMT promoter region, with some evidence of mediation by maternal COMT methylation. Specific genomic loci exhibited mutually exclusive maternal ACE effects on DNAm in either maternal or neonatal population. There is some evidence for an intergenerational effect of ACEs, supported by shared DNAm signatures in the COMT gene across maternal-neonatal paired samples.
Food price index prediction using time series models: A study of Cereals, Millets and Pulses
Authors: Majhi Santosh Kumar , Bano Rabiyanaz , Srichan Suresh Kumar , Acharya Biswaranjan , Al-Rasheed Amal , Alqahtani Mohammed S. , Abbas Mohamed , Soufiene Ben Othman 
Published: June 2023

Abstract

The prediction of household food price index has always been a significant challenge for the food industry, especially in developing countries like India, where the majority of the population depends on agriculture for their livelihoods. In this project, we aim to develop a food price index prediction system for household food items like cereals, millets, and pulses using three popular time-series forecasting models, namely SARIMA, ETS, and FB Prophet. We use historical price index data to build and evaluate the forecasting models. The performance of each method is assessed using evaluation metrics such as MAE and RMSE. The results show that all three methods can effectively predict the demand for food items with high accuracy. However, FB Prophet has better performance than the other two methods when it comes to forecasting accuracy and computation time. This project presents a food prediction model that can be used by grocery stores and households to effectively plan and manage their food inventory. The study highlights the effectiveness of time series forecasting techniques such as SARIMA, ETS, and FB Prophet in predicting the demand for household food items, which can aid in reducing food wastage and improving food supply chain management The developed forecasting model can help retailers and suppliers to manage their inventory and plan their production based on the predicted demand for household food items. Additionally, this study provides valuable insights into the application of time series forecasting methods in the food industry.
Great Lakes coastal wetland biodiversity increases following invasive Phragmites australis removal
Authors: Ward Meghan , Degazio Tarra , Bowman Jeff 
Published: June 2023

Abstract
Invasive Phragmites australis subsp. australis is invading Great Lakes coastal wetlands and forming monocultures at an alarming rate. P. australis is thought to reduce wetland biodiversity both directly and indirectly through the acquisition of resources and alteration of habitat. Restoration efforts to manually remove P. australis at Point Pelee National Park began in 2020 and here we assess the effect of P. australis removal on vegetation and emerging aquatic invertebrate communities. We compared emergent vegetation and emerging aquatic invertebrate communities between a P. australis-invaded wetland, a P. australis-treated wetland, and a non-invaded wetland. We found that two-years post-restoration, vegetation species richness and the prevalence of non-Phragmites vegetation were both higher in the treated and non-invaded wetlands than the invaded wetland. The vegetation community of the treated wetland resembled the vegetation community of the non-invaded wetland, and the vegetation community of the invaded wetland was very different from both the treated and non-invaded wetlands. We also found that invertebrate total abundance (measured as density/m2) was highest in the treated and non-invaded wetlands, and that invertebrate abundance differed among all wetland types. Invertebrate community composition also differed among all wetland types. Manual removal of P. australis resulted in significant changes in both the emergent vegetation and emerging invertebrate community composition two-years following restoration.
Radioactive Iodine Treatment for Graves’ Hyperthyroidism: Incidence of Graves Orbitopathy
Authors: Quah Nicole , Maenhout Annelies , Wren Alison , Scawn Richard , Kalogianni Eleni , Cleland James , Sobti Manvi 
Published: June 2023

Abstract
Purpose: There is limited recent data on the effect of radioactive iodine (RAI) for Graves’ disease on Graves’ orbitopathy (GO) development or reactivation. This audit investigates the GO incidence in patients with Graves’ disease after RAI treatment, explores risk factors present, and steroid prophylaxis use.
Methods: A retrospective audit of Graves’ disease patients treated with RAI over a 5-year period. Data collected: smoking status, thyroid-stimulating hormone receptor antibody (TRAb) status, GO history, Graves’ disease duration, eye features pre- and post-treatment, prophylactic corticosteroids, RAI dose given, post-RAI thyroid status, duration until hypothyroid.
Results: 101 patients were included, with median Graves’ disease duration 36 months. 34/101 (33.7%) were active/ex-smokers, 86/101 (85.1%) were TRAb-positive, 11/101 (10.9%) had a GO history; 32 (31.7%) had eye features present. Median RAI dose given was 596MBq. 8/101 (7.9%) patients received prophylactic corticosteroid; 1 experienced a wrist fracture. 89/101 (88.1%) achieved hypothyroid state in the year after RAI. GO developed in 5/101 (5.0%), of which 4/5 (80%) were de novo in high-risk individuals who did not receive steroids. One was a GO reactivation despite steroids. Two required intravenous steroids with/without orbital radiotherapy, one completed oral steroid taper; the remainder were treated conservatively.
Conclusion: Our cohort had a lower GO incidence in patients with Graves’ disease receiving RAI, with majority arising de novo. It is essential that all patients are assessed for eye disease or risk factors and counselled adequately prior to RAI. The decision to initiate steroids should be undertaken in a multi-disciplinary setting involving endocrinologists and ophthalmologists.
Comorbidity and drug resistance of smear-positive pulmonary tuberculosis patients in the Yi Autonomous Prefecture of China: a cross-sectional study
Authors: Wang Tao , Zhou Chaoxin , Shang Lan , Zhou Xiyuan 
Published: June 2023

Abstract
Background
Tuberculosis (TB) has a high morbidity and mortality rate, and its prevention and treatment focus is on impoverished areas. The Liangshan Yi Autonomous Prefecture is a typical impoverished area in western China with insufficient medical resources and high HIV positivity. However, there have been few reports of TB and drug resistance in this area.
Methods
We collected the demographic and clinical data of inpatients with sputum smear positive TB between 2015 and 2021 in an infectious disease hospital in the Liangshan Yi Autonomous Prefecture. Descriptive analyses were used for the epidemiological data. The chi-square test was used to compare categorical variables between the drug-resistant and drug-susceptible groups, and binary logistic regression was used to analyse meaningful variables.
Results
We included 2263 patients, 79.9% of whom were Yi patients. The proportions of HIV (14.4%) and smoking (37.3%) were higher than previously reported. The incidence of extrapulmonary TB (28.5%) was high, and the infection site was different from that reported previously. When drug resistance gene detection was introduced, the proportion of drug-resistant patients became 10.9%. Patients aged 15–44 years (OR 1.817; 95% CI 1.162–2.840; P < 0.01) and 45–59 years (OR 2.175; 95% CI 1.335–3.543; P < 0.01) had significantly higher incidences of drug resistance than children and the elderly. Patients with a cough of ≥ 2 weeks had a significantly higher chance of drug resistance than those with < 2 weeks or no cough symptoms (OR 2.069; 95% CI 1.234–3.469; P < 0.01). Alcoholism (OR 1.741; 95% CI 1.107–2.736; P < 0.05) and high bacterial counts on sputum acid-fast smears (OR 1.846; 95% CI 1.115–3.058; P < 0.05) were significant in the univariate analysis.
Conclusions
Patients with Sputum smear positive TB who were hospitalised in this hospital had higher proportions of Yi nationality, smoking, HIV, and extrapulmonary TB. Ages 15–59 years and cough duration ≥ 2 weeks were risk factors for TB drug resistance. Meanwhile, alcohol abuse and high bacterial counts in sputum acid-fast smears may also be associated with TB drug resistance. These characteristics are related to poverty and insufficient health resources.