bluuebunny/crossref_metadata_2025_split huggingface dataset:
Low-density granulocytes are related to shorter pregnancy duration but not to interferon alpha protein blood levels in systemic lupus erythematosus
Authors: Torell Agnes , Stockfelt Marit , Larsson Gunilla , Blennow Kaj , Zetterberg Henrik , Leonard Dag , Rönnblom Lars , Saleh Muna , Sjöwall Christopher , Strevens Helena , Jönsen Andreas , Bengtsson Anders A. , Trysberg Estelle , Sennström Maria Majcuk , Zickert Agneta , Svenungsson Elisabet , Gunnarsson Iva , Christenson Karin , Bylund Johan , Jacobsson Bo , Rudin Anna , Lundell Anna-Carin 
Published: June 2023

AbstractBackgroundAn increased risk of pregnancy complications is seen in women with systemic lupus erythematosus (SLE), but the specific immunopathological drivers are still unclear. Hallmarks of SLE are granulocyte activation, type I interferon (IFN) overproduction, and autoantibodies. Here we examined whether low-density granulocytes (LDG) and granulocyte activation increase during pregnancy, and related the results to IFNα protein levels, autoantibody profile, and gestational age at birth.MethodsRepeated blood samples were collected during pregnancy in trimesters one, two, and three from 69 women with SLE and 27 healthy pregnant women (HC). Nineteen of the SLE women were also sampled late postpartum. LDG proportions and granulocyte activation (CD62L shedding) were measured by flow cytometry. Plasma IFNα protein concentrations were quantified by single molecule array (Simoa) immune assay. Clinical data were obtained from medical records.ResultsWomen with SLE had higher LDG proportions and increased IFNα protein levels compared to HC throughout pregnancy, but neither LDG fractions nor IFNα levels differed during pregnancy compared to postpartum in SLE. Granulocyte activation status was higher in SLE relative to HC pregnancies, and it was increased during pregnancy compared to after pregnancy in SLE. Higher LDG proportions in SLE were associated with antiphospholipid positivity but not to IFNα protein levels. Finally, higher LDG proportions in trimester three correlated independently with lower gestational age at birth in SLE.ConclusionOur results suggest that SLE pregnancy results in increased peripheral granulocyte priming, and that higher LDG proportions late in pregnancy are related to shorter pregnancy duration but not to IFNα blood levels in SLE.
Immunohistochemical detection of MUC5AC and MUC5B mucins in ferrets
Authors: Meyerholz David K. , Leidinger Mariah R. , Adam Goeken J. , Businga Thomas R. , Vizuett Sebastian , Akers Allison , Evans Idil , Zhang Yan , Engelhardt John F. 
Published: June 2023

Abstract
Objective
Cystic fibrosis (CF) is a genetic condition that causes abnormal mucus secretions in affected organs. MUC5AC and MUC5B are gel-forming mucins and frequent targets for investigations in CF tissues. Our objective was to qualify MUC5AC and MUC5B immunohistochemical techniques to provide a useful tool to identify, localize and interpret mucin expression in ferret tissues.

Results
MUC5AC and MUC5B mucins were detected most commonly in large airways and least in small airways, consistent with reported goblet cell density in airway surface epithelia. We evaluated whether staining method affected the detection of goblet cell mucins in serial sections of bronchial surface epithelia. Significant differences between stains were not observed suggesting common co-expression MUC5AC and MUC5B proteins in goblet cells of airway surface epithelia. Gallbladder and stomach tissues are reported to have differential mucin enrichment, so we tested these tissues in wildtype ferrets. Stomach tissues were enriched in MUC5AC and gallbladder tissues enriched in MUC5B, mucin enrichment similar to human tissues. Mucin immunostaining techniques were further qualified for specificity using lung tissue from recently generated MUC5AC−/− and MUC5B−/− ferrets. Qualified techniques for MUC5AC and MUC5B immunohistochemistry will be useful tools for mucin tissue studies in CF and other ferret models.
Monitoring the growth dynamics of Tetragenococcus halophilus strains in lupine moromi fermentation using a multiplex-PCR system
Authors: Link Tobias , Ehrmann Matthias A. 
Published: June 2023

Abstract
Objective
The microbiota of a seasoning sauce fermentation process is usually complex and includes multiple species and even various strains of one species. Moreover, composition and cell numbers of individual strains vary over the course of the entire fermentation. This study demonstrates the applicability of a multiplex PCR system to monitor growth dynamics of Tetragenococcus (T.) halophilus strains in order to evaluate their performance and help to select the most competitive starter strain.

Results
In a previous study we isolated T. halophilus strains from multiple lupine moromi fermentation processes and characterized them. In this study we wanted to monitor the growth dynamics of these strains in a competitive lupine moromi model fermentation process using a multiplex PCR system. Therefore, pasteurized lupine koji was inoculated with eight different T. halophilus strains, six from lupine moromi, one from an experimental buckwheat moromi fermentation process and the type strain DSM 20,339T, to create the inoculated lupine moromi pilot scale fermentation process. With the multiplex PCR system, we could detect that all strains could grow in lupine moromi but, that TMW 2.2254 and TMW 2.2264 outperformed all other strains. Both strains dominated the fermentation after three weeks with cell counts between 4 × 106 to 4 × 107 CFU/mL for TMW 2.2254 and 1 × 107 to 5 × 107 CFU/mL for TMW 2.2264. The pH dropped to value below 5 within the first 7 days, the selection of these strains might be related to their acid tolerance.
Parallel-in-time optimization of induction motors
Authors: Hahne Jens , Polenz Björn , Kulchytska-Ruchka Iryna , Friedhoff Stephanie , Ulbrich Stefan , Schöps Sebastian 
Published: June 2023

AbstractParallel-in-time (PinT) methods were developed to accelerate time-domain solution of evolutionary problems using modern parallel computer architectures. In this paper we incorporate one of the efficient PinT approaches, in particular, the asynchronous truncated multigrid-reduction-in-time algorithm, into a bound constrained optimization procedure applied to an induction machine. Calculation of an optimal motor geometry with respect to its efficiency in the steady state is thus parallelized at each iteration of the optimization algorithm. As a result, a more efficient motor model is obtained about 11 times faster compared to optimization using the standard sequential time stepping.
Device association and trajectory planning for UAV-assisted MEC in IoT: a matching theory-based approach
Authors: Zhang Xinjun , Zhang Guopeng , Wang Kezhi , Yang Kun 
Published: June 2023

AbstractUnmanned aircraft vehicles (UAVs)-enabled mobile edge computing (MEC) can enable Internet of Things devices (IoTD) to offload computing tasks to them. Considering this, we study how multiple aerial service providers (ASPs) compete with each other to provide edge computing services to multiple ground network operators (GNOs). An ASP owning multiple UAVs aims to achieve the maximum profit from providing MEC service to the GNOs, while a GNO operating multiple IoTDs aims to seek the computing service of a certain ASP to meet its performance requirements. To this end, we first quantify the conflicting interests of the ASPs and GNOs by using different profit functions. Then, the UAV scheduling and resource allocation is formulated as a multi-objective optimization problem. To address this problem, we first solve the UAV trajectory planning and resource allocation problem between one ASP and one GNO by using the Lagrange relaxation and successive convex optimization (SCA) methods. Based on the obtained results, the GNOs and ASPs are then associated in the framework based on the matching theory, which results in a weak Pareto optimality. Simulation results show that the proposed method achieves the considerable performance.
A survey on the handover management in 5G-NR cellular networks: aspects, approaches and challenges
Authors: Haghrah Amiraslan , Abdollahi Mehran Pourmohammad , Azarhava Hosein , Niya Javad Musevi 
Published: June 2023

AbstractWith the purpose of providing higher data rate and ultra-reliable and low-latency communications for the users, employing the small cells in the upcoming Fifth-Generation-New Radio (5G-NR) cellular networks and beyond is leading to the serious challenges in mobility management due to dynamicity of the user equipments (UEs). Among different issues related to the mobility of the UEs, the handover management is one of the key procedures to let the UEs experience a high quality of service (QoS)/quality of experience (QoE). So far, many protocols and algorithms have been proposed to enhance the mobility management in 5G-NR from various aspects, but still a thorough survey has not been incorporated to summarize the recent advances and future directions of the mentioned issue. Thus, the handover management and the corresponding challenges stand in the center of concentrations in this paper, with a glance on 4G to the advancements of 5G-NR. The challenges include QoS/QoE, throughput, delay, traffic load, the attacks during authentication process and resource allocation. To overcome the mentioned challenges, the handover procedure is evaluated by some key performance indicators such as handover ratio, handover failure, radio link failure and such like which depend on the received signal quality. The lack of new advancements and novel aspects of handover plus the separation of security and handover issues in previous works are perceived as research gaps and motivations for the current paper. In this regard, this paper aims to specify and analyze the technical issues, to provide an overview on the proposed methods and recent advances and to bring the future directions into the limelight. We categorize the concurrent standards and methods about the handover, and then, we survey the proposed algorithms including theoretical, algorithm-based and pattern-capturing approaches following the authentication process along with the vulnerabilities and the algorithms to counteract the attacks during handover. Also, we study various issues corresponding to network performance during the handover procedure. Finally, we discuss the open problems and future research directions.
HPV self-sampling versus healthcare provider collection on the effect of cervical cancer screening uptake and costs in LMIC: a systematic review and meta-analysis
Authors: Mekuria Selamawit F. , Timmermans Sydney , Borgfeldt Christer , Jerkeman Mats , Johansson Pia , Linde Ditte Søndergaard 
Published: June 2023

Abstract
Background
Cervical cancer is a major global health issue, with 89% of cases occurring in low- and middle-income countries (LMICs). Human papillomavirus (HPV) self-sampling tests have been suggested as an innovative way to improve cervical cancer screening uptake and reduce the burden of disease. The objective of this review was to examine the effect of HPV self-sampling on screening uptake compared to any healthcare provider sampling in LMICs. The secondary objective was to estimate the associated costs of the various screening methods.

Method
Studies were retrieved from PubMed, Embase, CINAHL, CENTRAL (by Cochrane), Web of Science, and ClinicalTrials.gov up until April 14, 2022, and a total of six trials were included in the review.
Meta-analyses were performed mainly using the inverse variance method, by pooling effect estimates of the proportion of women who accepted the screening method offered. Subgroup analyses were done comparing low- and middle-income countries, as well as low- and high-risk bias studies. Heterogeneity of the data was assessed using I2. Cost data was collected for analysis from articles and correspondence with authors.

Results
We found a small but significant difference in screening uptake in our primary analysis: RR 1.11 (95% CI: 1.10–1.11; I2 = 97%; 6 trials; 29,018 participants). Our sensitivity analysis, which excluded one trial that measured screening uptake differently than the other trials, resulted in a clearer effect in screening uptake: RR: 1.82 (95% CI: 1.67–1.99; I2 = 42%; 5 trials; 9590 participants). Two trials reported costs; thus, it was not possible to make a direct comparison of costs. One found self-sampling more cost-effective than the provider-required visual inspection with acetic acid method, despite the test and running costs being higher for HPV self-sampling.

Conclusion
Our review indicates that self-sampling improves screening uptake, particularly in low-income countries; however, to this date, there remain few trials and associated cost data. We recommend further studies with proper cost data be conducted to guide the incorporation of HPV self-sampling into national cervical cancer screening guidelines in low- and middle-income countries.

Systematic review registration
PROSPERO CRD42020218504.
Generalized contraction mappings in double controlled metric type space and related fixed point theorems
Authors: Azmi Fatima M. 
Published: June 2023

AbstractIn this article, we introduce two new types of generalized contraction mappings in double controlled metric type spaces: Θ-double controlled contraction mapping and Ćirić-Reich-Rus-type-Θ-double controlled contraction mapping. For each contraction mapping, we establish the existence and uniqueness of the fixed point theorems on the complete double controlled metric type space and provide examples. We present an application of our results and demonstrate how our results generalize several existing fixed point theorems in the literature.
Regional vulnerability of brain white matter in vanishing white matter
Authors: Man Jodie H.K. , van Gelder Charlotte A.G.H. , Breur Marjolein , Molenaar Douwe , Abbink Truus , Altelaar Maarten , Bugiani Marianna , van der Knaap Marjo S. 
Published: June 2023

AbstractVanishing white matter (VWM) is a leukodystrophy that primarily manifests in young children. In this disease, the brain white matter is differentially affected in a predictable pattern with telencephalic brain areas being most severely affected, while others remain allegedly completely spared. Using high-resolution mass spectrometry-based proteomics, we investigated the proteome patterns of the white matter in the severely affected frontal lobe and normal appearing pons in VWM and control cases to identify molecular bases underlying regional vulnerability. By comparing VWM patients to controls, we identified disease-specific proteome patterns. We showed substantial changes in both the VWM frontal and pons white matter at the protein level. Side-by-side comparison of brain region-specific proteome patterns further revealed regional differences. We found that different cell types were affected in the VWM frontal white matter than in the pons. Gene ontology and pathway analyses identified involvement of region specific biological processes, of which pathways involved in cellular respiratory metabolism were overarching features. In the VWM frontal white matter, proteins involved in glycolysis/gluconeogenesis and metabolism of various amino acids were decreased compared to controls. By contrast, in the VWM pons white matter, we found a decrease in proteins involved in oxidative phosphorylation. Taken together, our data show that brain regions are affected in parallel in VWM, but to different degrees. We found region-specific involvement of different cell types and discovered that cellular respiratory metabolism is likely to be differentially affected across white matter regions in VWM. These region-specific changes help explain regional vulnerability to pathology in VWM.
An approach to automatic classification of hate speech in sports domain on social media
Authors: Vujičić Stanković Staša , Mladenović Miljana 
Published: June 2023

AbstractHate Speech encompasses different forms of trolling, bullying, harassment, and threats directed against specific individuals or groups. This phenomena is mainly expressed on Social Networks. For sports players, Social Media is a means of communication with the widest part of their fans and a way to face different cyber-aggression forms. These virtual attacks can harm players, distress them, cause them to feel bad for a long time, or even escalate into physical violence. To date, athletes were not observed as a vulnerable group, so they were not a subject of automatic Hate Speech detection and recognition from content published on Social Media. This paper explores whether a model trained on the dataset from one Social Media and not related to any specific domain can be efficient for the Hate Speech binary classification of test sets regarding the sports domain. The experiments deal with Hate Speech detection in Serbian. BiLSTM deep neural network was learned with different parameters, and the results showed high Precision of detecting Hate Speech in sports domain (96% and 97%) and pretty low Recall.
Soil factors that contribute to the abundance and structure of the diazotrophic community and soybean growth, yield, and quality under biochar amendment
Authors: Wang Weihua , Shi Fenfen , Du Jianqiang , Li Liangbin , Bai Ting , Xing Xuguang 
Published: June 2023

Abstract
Background
A 2-year field trial was conducted to test the effect of biochar addition (0, 15, 30, and 45 t hm−2) on soil properties, nutrients, diazotrophic community diversity, abundance, and structure, and soybean growth, yield, and quality. Furthermore, we aimed to explore the responses of diazotrophs, grain yield, and quality to nine soil environmental factors. Rhizosphere soil and plant samples were collected after harvest.

Results
Biochar application resulted in a lower soil bulk density (γd) but higher total organic carbon (TOC), effective phosphorus (AP) and total nitrogen (TN). Compared with untreated soil, the diversity index of diazotrophic bacteria in biochar-amended soil decreased, but the abundance of diazotrophic bacteria increased. The microbial community remained stable when a small amount of biochar was applied but changed as biochar amount increased. Furthermore, biochar reduced the proportion of unique nitrogen-fixing bacteria, but did not affect that of common nitrogen-fixing bacteria between biochar-amended and untreated soils, and increased the relative abundance of Bradyrhizobium (B9 vs. B0) and Sinorhizobium (B18 or B21 vs. B0) involved in symbiotic nitrogen fixation. The main components and content of fatty acids (except for stearic acid) and the content of protein and soybean oil remained stable under biochar application. The low biochar treatment (15 t hm−2) promoted soybean growth and yield. Redundancy analysis suggested that TN greatly influenced the diazotrophic community structure at the phylum and genus levels, and that pH, TOC, and NO3−-N greatly influenced grain yield and quality.

Conclusions
Soil diazotroph environment can be improved by targeted farmland implementation based on changes in soil physicochemical properties, which would benefit biological N fixation in agricultural soils and further increase economic benefit.

Graphical Abstract
The solid component within part-solid nodules: 3-dimensional quantification, correlation with the malignant grade of nonmucinous pulmonary adenocarcinomas, and comparisons with 2-dimentional measures and semantic features in low-dose computed tomography
Authors: Liu Jieke , Xie Chaolian , Li Yong , Xu Hao , He Changjiu , Qing Haomiao , Zhou Peng 
Published: June 2023

Abstract
Background
There is no consensus on 3-dimensional (3D) quantification method for solid component within part-solid nodules (PSNs). This study aimed to find the optimal attenuation threshold for the 3D solid component proportion in low-dose computed tomography (LDCT), namely the consolidation/tumor ratio of volume (CTRV), basing on its correlation with the malignant grade of nonmucinous pulmonary adenocarcinomas (PAs) according to the 5th edition of World Health Organization classification. Then we tested the ability of CTRV to predict high-risk nonmucinous PAs in PSNs, and compare its performance with 2-dimensional (2D) measures and semantic features.

Methods
A total of 313 consecutive patients with 326 PSNs, who underwent LDCT within one month before surgery and were pathologically diagnosed with nonmucinous PAs, were retrospectively enrolled and were divided into training and testing cohorts according to scanners. The CTRV were automatically generated by setting a series of attenuation thresholds from − 400 to 50 HU with an interval of 50 HU. The Spearman’s correlation was used to evaluate the correlation between the malignant grade of nonmucinous PAs and semantic, 2D, and 3D features in the training cohort. The semantic, 2D, and 3D models to predict high-risk nonmucinous PAs were constructed using multivariable logistic regression and validated in the testing cohort. The diagnostic performance of these models was evaluated by the area under curve (AUC) of receiver operating characteristic curve.

Results
The CTRV at attenuation threshold of -250 HU (CTRV− 250HU) showed the highest correlation coefficient among all attenuation thresholds (r = 0.655, P < 0.001), which was significantly higher than semantic, 2D, and other 3D features (all P < 0.001). The AUCs of CTRV− 250HU to predict high-risk nonmucinous PAs were 0.890 (0.843–0.927) in the training cohort and 0.832 (0.737–0.904) in the testing cohort, which outperformed 2D and semantic models (all P < 0.05).

Conclusions
The optimal attenuation threshold was − 250 HU for solid component volumetry in LDCT, and the derived CTRV− 250HU might be valuable for the risk stratification and management of PSNs in lung cancer screening.
Effect of initial failure geometry on the progress of a retrogressive seepage-induced landslide
Authors: Rajabian Ahmad 
Published: June 2023

AbstractNatural and man-made slopes can undergo a retrogressive landslide when subjected to seepage. Studying the mechanism of retrogressive landslides contributes greatly to the employment of effective mitigation approaches. A multi-stage limit equilibrium-based study was performed to explore how the geometry of initial failure affects the progress of a retrogressive, multiple-rotational landslide caused by seepage flow. Seepage-stability analyses were carried out on two silty sand slopes which were previously found to experience successive rotational failures upon raising the water table in centrifuge tests. Analyzed in prototype dimensions were the slope models with the height of 24 cm and inclinations of 45° (1V:1H) and 63.4° (2V:1H) tested at different centrifugal accelerations. According to the tests, the initial shallow failures were assumed to be circular initiating from the face and emerging from the toe of the slopes in the stability analyses. The impact of curvature and length of the initial failure surface (referred to as IFS) as well as the height of the scarp shaped at each failure episode were investigated. The results show that the landslide continues until the slope profile finds a stable curvature. For the landslides that occur in the 45° inclined slope, when the initial failure initiates at a higher elevation on the slope face, the landslide retrogresses further. In addition, with an increase in the length or curvature of IFS, the final retrogression distance decreases. Further, it was observed that the progress of landslides depends on the height of the scarp exposed at each failure episode.