bluuebunny/crossref_metadata_2025_split huggingface dataset:
Children With Developmental Language Disorder Show Deficits in the Production of Musical Rhythmic Groupings
Authors: Kreidler Kathryn , Vuolo Janet , Goffman Lisa 
Published: September 2023

Purpose:
Children with developmental language disorder (DLD) show evidence of domain-general deficits in sequentially patterned motor skills. This study focuses on the production of rhythmically grouped sequences drawn from a music task, with the hypothesis that children with DLD will show a sequential pattern learning deficit that crosses language and action domains.

Method:
Fifty-seven 4- to 5-year-old children (36 with DLD) drummed and clapped a developmentally appropriate musical rhythmic sequence 24 times (clapped 12 times, drummed 12 times). The accuracy of rhythmic events (markings of claps, drums, and pauses in a target sequence) was assessed through a modification of classic speech and language transcription procedures. The variability and prosodic structure of the rhythmic groupings were also measured.

Results:
Children with DLD produced less accurate and more variable rhythmic groupings compared to their typically developing (TD) peers. While the final-position grouping of the sequence was especially vulnerable for all children, those with DLD included more co-occurring errors in initial and final groupings of the same rhythmic sequence. Both TD children and children with DLD were less accurate in the clapping than the drumming task. Neither rhythmic drumming nor clapping accuracy correlated with motor skill in either group of children.

Conclusions:
This study provides novel evidence of a manual rhythmic grouping deficit in DLD, one that is motivated by language—not motor or speech—factors. Cognitive abilities necessary to organize rhythmic events into higher order groupings are impaired across music and language in children with DLD. Rhythmic organization and sequencing may serve an important role in diagnosis and intervention in this population.

Supplemental Material:

https://doi.org/10.23641/asha.24158745
Pediatric Unilateral Vocal Fold Paralysis
Authors: Barson Paula , Carroll Linda , Zur Karen B. 
Published: September 2023

Purpose:
The aim of this case study was to provide a review of a pediatric patient diagnosed with unilateral vocal fold paralysis.

Method:
The case history, voice samples, laryngeal examinations, and diagnostic probes were reviewed in a 10-year-old girl with the chief complaint of persistent dysphonia, characterized by use of both a breathy and a typical voice. Perceptual ratings were completed using both Consensus Auditory-Perceptual Evaluation of Voice and Grade, Roughness, Breathiness, Asthenia, and Strain scales. Cepstral peak prominence was determined and compared for the same file segment using both Praat and Analysis of Dysphonia in Speech and Voice analysis programs. Treatment probes during the initial preoperative visit are described.

Results:
The patient was able to compensate for short phonation tasks, but longer conversations were judged to have increased dysphonia and increased vocal fatigue. Because noted compensation was unable to be stabilized or sustained, both a reinnervation of the ansa cervicalis to the recurrent laryngeal nerve and voice therapy techniques were recommended as part of the multidisciplinary team plan.

Conclusion:
Pediatric patients with unilateral vocal fold paralysis may present with complex phonatory behaviors. This case study paired with supplemental acoustic and videostroboscopy files provides an opportunity to practice both an auditory-perceptual and acoustic assessment and to rate a laryngeal examination.

Supplemental Material:

https://doi.org/10.23641/asha.24163926
Living in the Void Between Hearing Health Care Encounters: Evaluation of the Barriers Families Face
Authors: Richlin Blair C. , Blaiser Kristina M. , Bush Matthew 
Published: September 2023

Purpose:There is a clear need for speech-language pathologists, audiologists, and related health care professionals to understand the barriers to hearing health care, so that we may propose possible solutions. Through interview, collaboration, and analysis, the objective was to identify opportunities to enhance support provided for these children.Method:The authors conducted a review of available literature related to hearing health care disparities. Dr. Matthew Bush, an expert in hearing health care disparities and advocacy, was interviewed on October 12, 2022. Data were extracted and compiled from available literature and the interview including demographics, themes, and available interventions.Results:The section “Entry Barriers” describes findings in the main categories of Steps, Proximity, Health Care Literacy, and Systemic Inequalities. The “Opportunities for Change” section describes topics from the interview for ongoing discussion in the field.Conclusions:Ultimately, having this conversation led exactly in a direction that it should—toward further professional development, awareness, and a call to action. To facilitate meaningful change, we are tasked with active discussion, questioning, probing, and improvement. Only through evolution of existing systemic bias and harmful structures can we make meaningful change.
Evaluation of an Emergency Drive System for a Disabled Arterial Pump Head
Authors: Long George W. , Fleenor Jonathan T. 
Published: September 2023

This study evaluates an Emergency Drive System (E.D.S.) developed by the authors to provide an electrically
powered drive system for a disabled arterial pump head.
The methods used in this study were designed to evaluate the E.D.S. under simulated clinical conditions using an American Optical Model 16655 pump with 1/2″ tubing in the arterial pump head and a Sarns 5000 pump with 3/8″ tubing in the arterial pump head. The E.D.S. was applied to the .arterial pump head and was required to produce a six liter per minute flow based on the revolutions per minute of the pump head. The study was deemed successful if the E.D.S. was capable of providing the revolutions per minute for a two hour period.
The E.D.S. was capable of providing the 100 revolutions per minute for American Optical pump and the 230 revolutions per minute for the Sarns 5000 pump, necessary to produce a six liter per minute flow rate.
In conclusion our study shows the E.D.S. is an easy and accurate device for providing temporary power to a disabled arterial pump head.
Einsatz von Implantaten zur Versorgung der männlichen Harninkontinenz
Authors: Rojas Cruz Cesar , Hakenberg Oliver , Dräger Desiree Louise 
Published: September 2023

ZusammenfassungBehandlungen für benigne und maligne Erkrankungen der Prostata können die Harnkontinenz beeinträchtigen. Harninkontinenz reduziert die Lebensqualität der Patienten und schränkt ihre Fähigkeit ein, normale Aktivitäten auszuführen. Der Grad der Harninkontinenz ist unterschiedlich und die damit verbundenen Beschwerden veranlassen Patienten dazu, sich behandeln zu lassen. Im Zentrum der Behandlung stehen chirurgische Eingriffe, die durch den Einsatz von Implantaten die beeinträchtigte Schließmuskelfunktion der männlichen Urethra ersetzen sollen. Der künstliche Harnröhrensphinkter gilt seit seiner Entwicklung in den 1970er-Jahren als Standard zur Therapie von männlichen Harninkontinenz. Erst kürzlich hat sich gezeigt, dass artifizielle Sphinkter und Schlingen bei einer ausgewählten Gruppe inkontinenter Männer wirksam sind. Zu den Zielen der chirurgischen Behandlung der Inkontinenz gehören die Erhaltung der Blasenfunktion, die Fähigkeit, die Stärke des Harnröhrensphinkters zu verbessern und den Urinverlust zu reduzieren oder zu beseitigen, und damit die Lebensqualität zu verbessern. Ziel der Artikel ist die Darstellung verschiedener Implantate zur Korrektur der männlichen Harninkontinenz.
Liquid Biopsy – Ein neues diagnostisches Konzept in der Onkologie
Authors: Heidrich Isabel , Roeper Carmen M.T. , Rautmann Charlotte , Pantel Klaus , Smit Daniel J. 
Published: September 2023

ZusammenfassungDie Analyse von im Blut zirkulierenden Tumorzellen oder von in anderen Körperflüssigkeiten zirkulierenden Tumorzellprodukten gewann in den letzten Jahren stetig an Aufmerksamkeit. Sie wird unter dem Begriff Flüssigbiopsie (Liquid Biopsy, LB) zusammengefasst. In diesem Beitrag werden die wichtigsten LB-Analyten vorgestellt sowie die noch bestehenden Hürden und vielfältigen Bemühungen der Implementierung der LB in die klinische Routine diskutiert.
High Throughput Newborn Screening for Sickle Cell Disease –
Application of Two-Tiered Testing with a qPCR-Based Primary
screen
Authors: Janda Joachim , Hegert Sebastian , Bzdok Jessica , Tesorero Rafael , Holtkamp Ute , Burggraf Siegfried , Schuhmann Elfriede , Hörster Friedrike , Hoffmann Georg F. , Janzen Nils , Okun Jürgen G , Becker Marc , Durner Jürgen 
Published: September 2023

Abstract
Background Sickle cell disease (SCD) is a group of hemoglobinopathies with
a common point mutation causing the production of sickle cell hemoglobin (HbS).
In high-throughput newborn screening (NBS) for SCD, a two-step procedure is
suitable, in which qPCR first pre-selects relevant samples that are
differentiated by a second method.
Methods Three NBS centers using qPCR-based primary screening for SCD
performed a laboratory comparison. Methods using tandem MS or HPLC were used for
differentiation.
Results In a benchmarking test, 450 dried blood samples were analyzed.
Samples containing HbS were detected as reliably by qPCR as by methods
established for hemoglobinopathy testing. In a two-step screening approach, the
2nd-tier-analyses have to distinguish the carrier status from
pathological variants. In nine months of regular screening, a total of 353,219
samples were analyzed using two-stage NBS procedures. The 1st-tier
screening by qPCR reduced the number of samples for subsequent differentiation
by>99.5%. Cases with carrier status or other variants were
identified as inconspicuous while 78 cases with SCD were revealed. The derived
incidence of 1:4,773, is in good agreement with previously published
incidences.
Conclusion In high-throughput NBS for SCD, qPCR is suitable to focus
2nd-tier analyses on samples containing HbS, while being
unaffected by factors such as prematurity or transfusions. The substantial
reduction of samples numbers positively impacts resource conservation,
sustainability, and cost-effectiveness. No false negative cases came to
attention.
Palliativmedizinische Versorgung durch Spezialisierte Palliativteams
– SAPV im Jahr 2023
Authors: Joist Thomas , Joist Regine , Wagner Stefanie , Wille-Friederichs Annette 
Published: September 2023

ZusammenfassungDie palliativmedizinische Versorgung im ambulanten Bereich ist heute wesentlicher
und integraler Bestandteil der Begleitung schwerstkranker und sterbender
Patienten. Die Versorgung erfolgt – die individuellen
Bedürfnisse des Patienten berücksichtigend – in
verschiedenen miteinander verbundenen Stufen. Multiprofessionalität und
ständige Verfügbarkeit für die Patienten sind
wesentliches Kennzeichen der spezialisierten ambulanten Palliativversorgung
(SAPV). Die meisten der in der SAPV betreuten Patienten leiden an einer
onkologischen Erkrankung. Deshalb ist die Verbindung von SAPV und Onkologie sehr
eng. Die Zusammenarbeit mit eigenständigen SAPV-Teams sollte
frühzeitig erfolgen, um einen Verbleib und auch ein Versterben zu Hause
sicherzustellen. Denn dies entspricht dem überwiegenden Wünschen
unserer Patienten.
Endoscopic ultrasound-guided perivascular pancreatic radiofrequency ablation using a hydroxyethyl starch solution prior to pancreatectomy
Authors: Montanelli Julieta , Sosa-Valencia Leonardo , Badaoui Abdenor , Averous Gerlinde , Swanstrom Lee , Mutter Didier , Pessaux Patrick , Seeliger Barbara 
Published: September 2023

Abstract
Background and study aims Pancreatic surgery remains complex,
particularly for borderline resectable and locally advanced tumors. Vascular invasion
compromises resectability, and vascular resection entails increased morbidity and mortality.
Following a feasibility and safety demonstration of augmented endoscopic ultrasound
(EUS)-guided radiofrequency ablation (RFA) using hydroxyethyl starch (HES) in porcine
pancreatic parenchyma, the present study assesses whether this approach (EUS-sugar-RFA) in the
pancreatic perivascular space is safe and creates a controllable margin of necrosis to enable
a vessel-sparing resection.
Methods EUS-sugar-RFA in the pancreatic parenchyma adjacent to
the splenic artery and vein was performed in a live animal model. Following different survival
periods (0–4 days) in the interventional group (n = 3), open pancreatectomy was carried out.
The control group (n = 4) included open pancreatectomies in two pigs with non-treated
pancreases and in two with pancreatic RFA alone on the same day.
Results All procedures were completed successfully, without
intraoperative or postoperative complications. Survival periods were uncomplicated.
Histopathological examination showed local necrosis and inflammatory reaction at the ablation
sites. Vascular wall integrity was preserved in all specimens. The untreated pancreatic zones
in the interventional group were no different from the normal pancreases in the control
group.
Conclusions Preoperative perivascular augmented RFA using HES was
safe, and in the pancreatic animal model, the best timeframe was within 24 hours before
pancreatic surgery. This technique might improve resectability in selected borderline and
locally advanced pancreatic cancers.
Long-term results after EUS gallbladder drainage in high-surgical-risk patients with acute cholecystitis: A 3-year follow-up registry
Authors: Martinez-Moreno Belen , López-Roldán Gonzalo , Martínez-Sempere Juan , de-Madaria Enrique , Jover Rodrigo , Aparicio José Ramón 
Published: September 2023

Abstract
Background and study aims Endoscopic ultrasound-guided gallbladder drainage (EUS-GBD) has become the favorite drainage option for high surgical-risk patients with acute cholecystitis. However, data on long-term outcomes regarding efficacy and security over 1 year are scarce.
Patients and methods We performed a retrospective review of a prospectively maintained database to analyze the 3-year long-term outcomes of EUS-GBD with lumen apposing metal stents (LAMS) in high-surgical-risk patients with acute cholecystitis.
Results Fifty patients with acute cholecystitis who underwent
EUS-GBD with LAMS and 3-year follow-up or until death were included in this study. No
endoscopic revisions were scheduled unless an adverse event (AE) or suspected LAMS dysfunction
occurred. AEs occurred in 18%, 20%, and 26% of patients in the first, second, and third years,
respectively. Thirteen patients developed at least one AE, and six presented with a second AE
during follow-up. Recurrence of cholecystitis occurred in two patients (4%). Seven stent
migrations (14%) occurred but all were asymptomatic. Symptomatic LAMS-related AEs (LAMS-RAEs)
(37.5%) were related to gastric location of the stent compared with duodenal location (66.7%
vs. 12.5%, P = 0.03). No stent-related bleeding or stent-related
mortality was observed.
Conclusions EUS-GBD with LAMS without scheduled removal is an effective and safe long-term treatment in high-surgical-risk patients with acute cholecystitis. Late LAMS-RAEs tend to be more asymptomatic over time. Symptomatic LAMS-RAEs are associated with gastric location, and overall, AEs tend to recur.
Duodenal neuroendocrine tumors: Short-term outcomes of endoscopic submucosal dissection performed in the Western setting
Authors: Gupta Sunil , Kumar Puja , Chacchi Rocio , Murino Alberto , Despott Edward J , Lemmers Arnaud , Pioche Mathieu , Bourke Michael J. 
Published: September 2023

Abstract
Background and study aims Endoscopic resection (ER) is recommended for the management of duodenal neuroendocrine tumors (D-NETs) confined to the submucosal layer, without lymph node or distant metastasis. While this is accepted practice for lesions < 10 mm, consensus for larger lesions remains unclear. Although endoscopic submucosal dissection (ESD) has been proposed as the preferred ER technique for DNETs ≥10 mm, there are limited data on efficacy and safety, particularly in the Western setting.
Patients and methods We performed a retrospective analysis of patients with D-NETs who underwent ESD between 2012 and 2022 in three tertiary referral centers in Australia, France, and Belgium.
Results Fourteen patients with 15 D-NETs were evaluated. Median patient age was 64 years (interquartile range [IQR] 58–70 years). All D-NETs were confined to the duodenal bulb. Median D-NET size was 10 mm (IQR 7–12 mm) and specimen size was 15 mm (IQR 15–20 mm). Median procedure time was 60 minutes (IQR 25–90 minutes). The rate of en bloc resection was 100%. Intra-procedural perforation occurred in four patients (26.7%), with all closed endoscopically without long-term sequelae. There were no episodes of clinically significant bleeding. No local recurrence, lymph node or distant metastasis was observed at a median follow-up of 19.9 months (IQR 10.3–49.3 months).
Conclusions In experienced hands, ESD for D-NETs can achieve a 100% en bloc resection rate. There were no cases of local recurrence or distant metastatic spread, indicating that ESD may be a viable option for patients with D-NETs 10 to 15 mm that are not surgical candidates.
Bone Tissue in Magnetic Resonance Imaging: Contribution of New Zero Echo Time Sequences
Authors: Vuillemin Valérie , Guerini Henri , Thévenin Fabrice , Sibileau Elodie , Corcos Gabriel , Khaled Wassef , Zeitoun Frédéric , Morvan Gérard 
Published: September 2023

AbstractThe introduction of new ultrashort and zero echo time (ZTE) sequences is revolutionizing magnetic resonance imaging (MRI) and optimizing patient management. These sequences acquire signals in tissues with very short T2: mineralized bone, cortical bone, and calcium deposits. They can be added to a classic MRI protocol. ZTE MRI provides computed tomography–like contrast for bone.
Ankyloglossia: Typical Characteristics, Effects on Function, and Clinical Implications
Authors: Kummer Ann W. 
Published: September 2023

AbstractThe purpose of this article is to (1) define the diagnostic characteristics of ankyloglossia, (2) identify potential problems associated with ankyloglossia, and (3) discuss treatment options, when treatment is appropriate. This article is based on a review of the literature, including recent systematic reviews, and the author's experience as a cleft and orofacial specialist. Ankyloglossia is a common congenital condition characterized by an anterior attachment of the lingual frenulum on the tongue. This causes difficulty elevating and/or protruding the tongue tip. As such, ankyloglossia has been thought to affect neonatal feeding, speech, and other functions. Although systematic reviews have concluded that most infants with ankyloglossia can be fed normally, a small percentage of affected infants will show improved efficiency of feeding post-frenotomy. They also concluded that frenotomy may relieve nipple pain in the breastfeeding mothers of affected infants. Regarding speech, the systematic reviews concluded that there is no evidence that ankyloglossia causes speech disorders. This may be because simple compensations will result in normal acoustics of the sounds. Therefore, frenotomy should be recommended sparingly for newborn infants, and it should rarely, if ever, be recommended for speech disorders.
Reproductive Health of Women with Epilepsy in India: An Observational Study
Authors: Kumar Aadithya Narayan Sunil , Aghoram Rajeswari , Keepanasseril Aneesh , Nair Pradeep P. 
Published: September 2023

Abstract
Objectives Women with epilepsy (WWE) have special reproductive health needs. We compare menstrual disorders, obstetric outcomes, and patterns of contraceptive use among WWE in the reproductive age group to those without epilepsy.
Methods Sixty WWE between the ages of 18 and 45 years were randomly selected from a hospital database, and 60 controls in the same age group were recruited from among their families or close contacts. A questionnaire adapted from the National Family Health Survey 5 (NFHS-5) was administered to collect data on menstrual patterns, obstetric outcomes, fertility preferences, and contraceptive use. Descriptive statistics were used. Graphical and cross-tabulations were used for comparisons. All statistics were performed on STATA version 14.2 (StataCorp, Texas, United States).
Results The demographic characteristics including mean age, education, and occupational status were comparable. Dysmenorrhea requiring use of pain killers was more common among WWE (odds ratio [OR]: 3.01; 95% confidence interval [CI]: 1.11–8.72); other menstrual disorders were equally frequent. Spontaneous fetal loss was seen in 25 (21.9%) of 114 pregnancies in WWE and 22 (17.9%) of 123 among control women. Demand for family planning was satisfied in 21 (65.6%) of 32 eligible WWE and 23 (62.2%) of 37 controls with the most common method being female sterilization. WWE knew fewer methods of contraception compared with controls (median: 2; interquartile range [IQR]: 1.2 vs. 4; IQR: 2.5; p < 0.0001).
Conclusion WWE had more dysmenorrhea and less knowledge of contraceptive methods compared with controls. Abnormal uterine bleeding, contraceptive use, and spontaneous fetal loss were similar in both groups.
Applications and Reliability of Dorsal Metacarpal Artery Perforator Flap
Authors: Jayachandiran Anand Prasath , Rajendran Suresh , Mahipathy Surya Rao Venkata , Durairaj Alagar Raja , Sundaramurthy Narayanamurthy , Ananthappan Manoj 
Published: September 2023

AbstractDorsal metacarpal artery perforator flap (DMAP), first described by Quaba and Davison, is a useful tool in the armamentarium of plastic surgeons. It provides like for like tissue for the reconstruction of dorsal finger defects. It is a simple and relatively easy flap to harvest with minimal donor site morbidity. In this case series, we present our experience, applications, and surgical technique of flap harvesting.
Internal Quality Control in Hemostasis Assays
Authors: Reilly-Stitt Christopher , Jennings Ian , Kitchen Steve , Walker Isobel D. 
Published: September 2023

AbstractInternal quality control (IQC) for routine and specialist hemostasis testing represents a mandatory requirement for assays offered by clinical laboratories under International Organization for Standardization, Code of Federal Regulations, and Clinical and Laboratory Standards Institute standards. The underlying principle is that regular IQC audits the analytical performance of automated, semiautomated, and manual methods. This review investigates IQC practices, including benefits, limitations, frequency per time period or batch, sources of material used, primary supplier, third party or in-house, plus troubleshooting when IQC falls outside acceptance criteria. To assess IQC practice, the UK National External Quality Assessment Scheme (NEQAS) Blood Coagulation distributed a questionnaire to 1,200 participants enrolled in our scheme that collected details of the local practices for IQC testing. We received returns from 127 centers that described their local practices for the frequency of IQC, the type of IQC material employed, acceptance criteria for IQC data, and troubleshooting protocols for IQC failures. The data collected as part of an NEQAS BC questionnaire confirmed that all the participants returning answers to the questionnaire meet the standards for regular IQC testing for the hemostasis assays they perform.