bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long-term cardiac effect of sacubitril-valsartan in hemodialysis patients with a reduced ejection fraction after aortic valve replacement for aortic stenosis: a case report with literature review
Authors: Daimon Shoichiro , Sakamoto Yuka , Yasuda Miyuki , Nishitani Mitsuhiro 
Published: April 2023

Abstract
Background
Although the angiotensin receptor-neprilysin inhibitor sacubitril-valsartan has demonstrated a valuable effect on cardiac function in patients with heart failure with a reduced ejection fraction, the effect of this agent in hemodialysis patients is not well known.

Case presentation
Sacubitril-valsartan was administered to two anuric hemodialysis patients, an 81-year-old woman and a 79-year-old man, after aortic valve replacement for aortic stenosis. Following sacubitril-valsartan administration, the two patients’ N-terminal pro-brain natriuretic peptide levels decreased from 110,373 to 47,742 and 22,723 to 7692 pg/mL within one month, respectively, and were sustained within the lower levels thereafter. Although the patients’ left ventricular ejection fractions were 40.0% and 28.4%, respectively, these values did not change at seven and four months after sacubitril-valsartan administration (41.0% and 30.0%, respectively) but increased gradually to 56.6% and 54.9% at 11 and 13 months, respectively, and were sustained at the same levels thereafter.

Conclusions
Long-term sacubitril-valsartan administration can improve cardiac function in hemodialysis patients with a reduced ejection fraction.
Circulating neutrophil extracellular trap (NET)-forming ‘rogue’ neutrophil subset, immunotype [DEspR + CD11b +], mediate multi-organ failure in COVID-19—an observational study
Authors: Herrera Victoria L. M. , Bosch Nicholas A. , Lok Judith J. , Nguyen Mai Q. , Lenae Kaitriona A. , deKay Joanne T. , Ryzhov Sergey V. , Seder David B. , Ruiz-Opazo Nelson , Walkey Allan J. 
Published: April 2023

Abstract
Background
Cumulative research show association of neutrophils and neutrophil extracellular traps (NETs) with poor outcomes in severe COVID-19. However, to date, there is no curative intent therapy able to block neutrophil/NETs-mediated progression of multi-organ dysfunction. Because of emerging neutrophil heterogeneity, the study of subsets of circulating NET-forming neutrophils [NET + Ns] as mediators of multi-organ failure progression among patients with COVID-19 is critical to identification of therapeutic targets.

Methods
We conducted a prospective observational study of circulating levels of CD11b + [NET + N] immunotyped for dual endothelin-1/signal peptide receptor (DEspR ±) expression by quantitative immunofluorescence-cytology and causal mediation analysis. In 36 consented adults hospitalized with mod-severe COVID-19, May to September 2020, we measured acute multi-organ failure via SOFA-scores and respiratory failure via SaO2/FiO2 (SF)-ratio at time points t1 (average 5.5 days from ICU/hospital admission) and t2 (the day before ICU-discharge or death), and ICU-free days at day28 (ICUFD). Circulating absolute neutrophil counts (ANC) and [NET + N] subset-specific counts were measured at t1. Spearman correlation and causal mediation analyses were conducted.

Results
Spearman correlation analyses showed correlations of t1-SOFA with t2-SOFA (rho rS = 0.80) and ICUFD (rS = -0.76); circulating DEspR + [NET + Ns] with t1-SOFA (rS = 0.71), t2-SOFA (rS = 0.62), and ICUFD (rS = -0.63), and ANC with t1-SOFA (rS = 0.71), and t2-SOFA (rS = 0.61).
Causal mediation analysis identified DEspR + [NET + Ns] as mediator of 44.1% [95% CI:16.5,110.6] of the causal path between t1-SOFA (exposure) and t2-SOFA (outcome), with 46.9% [15.8,124.6] eliminated when DEspR + [NET + Ns] were theoretically reduced to zero. Concordantly, DEspR + [NET + Ns] mediated 47.1% [22.0,72.3%] of the t1-SOFA to ICUFD causal path, with 51.1% [22.8,80.4%] eliminated if DEspR + [NET + Ns] were reduced to zero. In patients with t1-SOFA > 1, the indirect effect of a hypothetical treatment eliminating DEspR + [NET + Ns] projected a reduction of t2-SOFA by 0.98 [0.29,2.06] points and ICUFD by 3.0 [0.85,7.09] days. In contrast, there was no significant mediation of SF-ratio through DEspR + [NET + Ns], and no significant mediation of SOFA-score through ANC.

Conclusions
Despite equivalent correlations, DEspR + [NET + Ns], but not ANC, mediated progression of multi-organ failure in acute COVID-19, and its hypothetical reduction is projected to improve ICUFD. These translational findings warrant further studies of DEspR + [NET + Ns] as potential patient-stratifier and actionable therapeutic target for multi-organ failure in COVID-19.
Learning and teaching sustainable business in the digital era: a connectivism theory approach
Authors: Dziubaniuk Olga , Ivanova-Gongne Maria , Nyholm Monica 
Published: April 2023

AbstractHigher education institutions may adopt various approaches to the pedagogic principles and methods used in teaching sustainable development in business and marketing courses. These methods can include the utilisation of digital technologies and online communication to facilitate distance learning and fast access to relevant information. Changes towards the digitalisation of the learning environment especially gained popularity during the Covid-19 pandemic. In the post-pandemic period, digitalisation continues to facilitate the learning and teaching processes. However, the implementation of digital technologies, besides technological expertise, requires appropriate theoretical frameworks for understanding how learning is developed. This study explores connectivism theory applied to the pedagogic practices of knowledge dissemination concerning sustainable development in the fields of business and marketing. Connectivism embraces knowledge as a network where the learner, with the help of digital technologies, develops mental connections between pieces of information during interaction with various information sources. This qualitative research empirically explores the principles of connectivism embedded in the learning and teaching of a university course conducted online. The research findings indicate that connectivism may be a suitable conceptual framework that motivates learners to develop knowledge through digital enablers, discussions and social networking and to make connections to sustainability concepts. The principles of connectivism may help instructors to develop a learning environment where learners add understandings to their previous knowledge on sustainability through online interactions and by accessing digital knowledge sources. This study makes several interdisciplinary contributions by deepening the insights into digital pedagogic methods and approaches for the facilitation of learning, which may be of interest to academic and other pedagogic practitioners.
Risk factors-related first episode postpartum psychosis among Egyptian women: the role of psychosocial and the biological factors
Authors: Khedr Eman M. , Ramadan Ehab S. , Osman Mohamed N. , Ahmed Gellan K. 
Published: April 2023

AbstractBackgroundThe risks associated with postpartum psychosis (PP) are poorly recognized in Egyptian women. We aimed to study the role of sociodemographic, psychosocial, obstetric, and biological factors in the occurrence of PP within 4 weeks after delivery in a sample of Egyptian women. We included 60 women with PP and 30 postpartum women without psychosis. All participants underwent a full medical assessment and psychiatric assessment using the Holmes and Rahe Stress Scale, the Brief Psychiatric Rating Scale (BPRS), and hormonal assessment (including estrogen levels and thyroid function tests) were performed for each woman.ResultsThe mean age of pregnancy of women with PP was significantly younger than that of controls (19.2 ± 2.04 years versus 24.37 ± 4.92 years). PP was significantly more common among primipara (73.3%), women who underwent cesarean sections (58.3%) and had thyroid dysfunction. The rates of low birth weight, and premature delivery were significantly higher among women with PP than among those without PP. The mean time-lapse from parturition to the onset of PP symptoms was 6.11 ± 1.62 days. Sleep disturbance, and irritability symptoms were the earliest symptoms of PP in our study. Plasma estrogen levels were significantly correlated with the total BPRS scores in patients with PP (P = 0.001).ConclusionsYoung age, primiparity, low birth weight, cesarean delivery, a rapid drop in the estrogen level and thyroid dysfunction all could contribute to the occurrence of PP.
Chemopreventive potential of kimchi, an ethnic food from Korea, against colorectal carcinogenesis associated with red meat intake
Authors: Surya Reggie , Surya Ervan , Nugroho David , Romulo Andreas , Kamal Nurkhalida , Rahayu Winiati Pudji , Benchawattananon Rachadaporn , Oh Jin-Seok 
Published: April 2023

AbstractKimchi, the traditional fermented vegetables with seasonings from Korea, is globally renowned as healthy food with anticancer properties. Colorectal cancer is the world’s third leading cancer with an increasing incidence rate over the past years. High red meat intake is strongly associated with colorectal cancer, and the World Health Organization has identified red meat as probably carcinogenic to humans (Group 2A). This study aimed to investigate the chemopreventive potential of cabbage kimchi against the promotion of colorectal cancer by red meat in vivo using carcinogen-injected rats. Rats were fed by AIN-76 diet enriched in freeze-dried beef sirloin supplemented or not with kimchi powder for 120 days prior to killing. Kimchi supplementation at moderate (5%) and high (10%) concentration significantly suppressed the formation of precancerous lesions in the colon of red meat-fed rats. Using fecal water, the aqueous extract of feces, we found out that kimchi supplementation limited iron-mediated oxidation and reduced lipid peroxidation in the feces of rats. Furthermore, kimchi supplementation reduced the toxicity of fecal water of red meat-fed rats toward human colonic epithelial cells in vitro by suppressing the formation of cellular reactive oxygen species (ROS). The chemopreventive effects of kimchi were associated with the acidification of fecal matrix and increase in fecal lactic acid bacteria (LAB). Gene expression analysis in the colon of rats demonstrated that kimchi supplementation prevented colorectal carcinogenesis by up-regulating the expression of tumor-suppressor genes and antioxidant enzymes, as well as by down-regulating the expression of proinflammatory proteins. Taken together, our findings suggested that kimchi consumption is correlated with lower promotion of colorectal cancer associated with red meat intake.
Low-phospholipid associated cholelithiasis (LPAC) syndrome: an unusual form in an elderly and overweight woman
Authors: Razafindrazoto Chantelli Iamblaudiot , Ralaizanaka Behoavy Mahafaly , Rakotomalala Jolivet Auguste , Stern Christiane , Razafimahefa Soloniaina Hélio , Ramanampamonjy Rado Manitrala , Lebray Pascal 
Published: April 2023

Abstract
Background
Low-phospholipid associated cholelithiasis (LPAC) remains an under-diagnosed condition. It can be revealed by complications such as acute cholecystitis, acute angiocholitis and acute pancreatitis. We report a case of acute pancreatitis secondary to LPAC syndrome.

Case presentation
A 58-year-old woman was hospitalized for recurrent biliary-type abdominal pain after cholecystectomies. The diagnosis of acute biliary pancreatitis revealing a low-phospholipid associated cholelithiasis syndrome was retained after explorations. An abdominal ultrasound performed by an expert radiologist allowed us to confirm the diagnosis of LPAC syndrome, showing a comet tail image along the intrahepatic bile ducts. Ursodeoxycholic acid was started without waiting for the result of the ABCB4 mutation. The outcome was spectacular with complete disappearance of the symptoms after the first week.

Conclusion
Expert ultrasound remains the key examination for the confirmation of the diagnosis of a low-phospholipid associated cholelithiasis syndrome. It should be requested at the slightest warning signs such as a young age less than 40 years and recurrence of biliary symptoms after cholecystectomy.
Proptosis under evaluation—a rare case report on pseudolymphoma of orbit
Authors: Raguraman Sharulatha , Kushwaha Akshat , Penubarthi Lokesh Kumar 
Published: April 2023

Abstract
Background
Orbital pseudolymphoma is one of the rare diseases affecting the ocular adnexa and causing various symptoms requiring histopathological evidence for diagnosis and appropriate treatment with oral steroids or immunosuppressive agents. However, there is less literature available on this disease, thus adding to it will help in the early diagnosis and treatment of the patients.

Case presentation
A 48-year-old female from a village in South India came to our tertiary care centre with the only complaints of right eye protrusion for 1 year. With a working diagnosis of intraorbital mass, radiological investigations like contrast-enhanced CT and MRI were taken. It showed well-capsulated mass involving the right inferior rectus extending into the intraconal space just abutting the optic nerve. Trans-antral endoscopic biopsy under general anaesthesia was taken and reported as pseudolymphoma proven with CD 3 and CD 20 immunohistochemistry markers. The patient was treated with oral corticosteroids and tapered over a period of 3 months. During the treatment period, the patient developed no diminution of vision or new complaints.

Conclusion
Orbital pseudolymphomas are benign lymphoproliferative diseases affecting the ocular adnexal tissue. Patients can present with painless ptosis, proptosis, diplopia, or eyelid swelling. Prompt diagnosis and treatment result in the remission of the disease.
Observational viability of the intermediate DBI inflation in the presence of a minimal length
Authors: Rashidi N. , Roushan M. , Nozari K. 
Published: April 2023

Abstract
We consider an intermediate Dirac-Born-Infeld (DBI) inflationary model in the presence of a minimal measurable length in the theory. We show that the presence of a minimal measurable length modifies the definitions of the scalar and tensor spectral indices and also other inflation observables. This is due to modification of the momentum and corresponding wave number of the perturbations in the presence of a minimal length. By using the deformed definition of the scalar and tensor spectral indices, we perform numerical analysis on the intermediate DBI inflation model to find some constraints on the deformation parameter. In this regard, we compare our numerical results with both Planck2018 TT, TE, EE +lowE +lensing +BAO+ BK14 and Planck2018 TT, TE, EE +lowE+lensing+BK14 +BAO+LIGO and Virgo2016 data at the 68% CL and 95% CL. Our numerical study shows that the intermediate DBI inflation model in the presence of a minimal measurable length is observationally viable if the upper bound on the deformation parameter to be considered of the order of 1048 at 68% CL and 1049 at 95% CL. This is consistent with the results of other approaches to constrain such a quantity.
Recent Trends in Hypoparathyroidism-Related Inpatient and Emergency Department Admissions and Costs in the United States
Authors: Kaul Sanjiv , Gosmanova Elvira O , Castriota Felicia , Hitchens Abby , Candrilli Sean , Parikh Rohan , Esterberg Elizabeth , Ayodele Olulade 
Published: April 2023

Abstract
Hypoparathyroidism (HypoPT) is a rare disease associated with high morbidity. Its economic impact is not well understood. This retrospective, cross-sectional study used data from the United States-based National Inpatient Sample and the Nationwide Emergency Department Sample from 2010 to 2018 to quantify overall trends in number, cost, charges, and length of stay (LOS) for inpatient hospitalizations and number and charges for emergency department (ED) visits for HypoPT-related and for non-HypoPT-related causes. Additionally, the study estimated the marginal effect of HypoPT on total inpatient hospitalization costs and LOS as well as ED visit charges. Over the observed period, a mean of 56.8–66.6 HypoPT-related hospitalizations and 14.6–19.5 HypoPT-related ED visits were recorded per 100 000 visits per year. Over this period, the rate of HypoPT-related inpatient hospitalizations and ED visits increased by 13.5% and 33.6%, respectively. The mean LOS for HypoPT-related hospitalizations was consistently higher than for non-HypoPT-related causes. Total annual HypoPT-related inpatient hospitalization costs increased by 33.6%, and ED visit charges increased by 96.3%. During the same period, the annual costs for non-HypoPT-related hospitalizations and charges for ED visits increased by 5.2% and 80.3%, respectively. In all years, HypoPT-related hospital encounters resulted in higher charges and costs per individual visit than non-HypoPT-related encounters. The marginal effect of HypoPT on inpatient hospitalization costs and LOS, and on ED charges, increased over the period of observation. This study demonstrated that HypoPT was associated with substantial and increasing healthcare utilization in the United States between 2010 and 2018.
Direct force measurement and loading on developing tissues in intact avian embryos
Authors: Chan Chon U. , Xiong Fengzhu , Michaut Arthur , Vidigueira Joana M. N. , Pourquié Olivier , Mahadevan L. 
Published: April 2023

ABSTRACT
Developmental morphogenesis is driven by tissue stresses acting on tissue rheology. Direct measurements of forces in small tissues (100 µm-1 mm) in situ, such as in early embryos, require high spatial precision and minimal invasiveness. Here, we introduce a control-based approach, tissue force microscopy (TiFM), that integrates a mechanical cantilever probe and live imaging with closed-loop feedback control of mechanical loading in early chicken embryos. By testing previously qualitatively characterized force-producing tissues in the elongating body axis, we show that TiFM quantitatively captures stress dynamics with high sensitivity. TiFM also provides the means to apply stable, minimally invasive and physiologically relevant loads to drive tissue deformation and to follow the resulting morphogenetic progression associated with large-scale cell movements. Together, TiFM allows us to control tissue force measurement and manipulation in small developing embryos, and promises to contribute to the quantitative understanding of complex multi-tissue mechanics during development.
Artificial intelligence: what it is and what it can do for dentists
Authors: Schwendicke Falk , Arsiwala-Scheppach Lubaina T , Krois Joachim 
Published: April 2023

Artificial intelligence (AI) is an increasingly relevant topic for dental clinicians, with AI applications entering the clinical arena at a high pace. This article outlines what AI is, how it works, what its application fields are, but also what challenges the profession faces now and in the future. Computer vision, language processing, simulation and precision dentistry are the main fields where AI is, or will be, applied in dentistry. The ability to be generalizable to external data sources, be accurate, useful and easy to explain are the main cornerstones of AI for health applications. Clinicians should be able to appraise AI applications before integrating them in their daily workflow. AI will be useful for synthesizing an increasing amount of data in dentistry, allowing more automated, efficient and precise care. Certain tools will also facilitate patient communication and documentation. Dentists should critically evaluate AI against certain quality criteria and standards. CPD/Clinical Relevance: It is important to be aware of the applications of artificial intelligence in dentistry.
Disappearing teeth. The story of infra-occlusion of primary molars: diagnosis, aetiology and management
Authors: Hamilton Sean , Oliver Graham , Chawla Ourvinder , Atack Nicola E 
Published: April 2023

This article outlines the aetiology, diagnosis and treatment options available for the management of infra-occluded primary molars. Treatment decisions are mainly guided by the clinical presentation of the infra-occluded tooth, the malocclusion, the age of the patient, the presence or absence of the permanent successor and, of course, the wishes of the patient and/or parents. CPD/Clinical Relevance: It is important that infra-occlusion is diagnosed and managed in a timely way to prevent potentially avoidable complications.
Species diversity of gastropods (Cypraeidae and Conidae) at Krakal Beach, Gunungkidul, Yogyakarta, Indonesia
Authors: FEBIANSI DEA , RAHMAYANTI FERINTA , RAHMAYANTI FERINTA , KURNIA RIFA NINGMAS , SILMI MALYA ADZILLINA , DEWI ARISMA KUSUMA , MILLATY IRKHAMNA NOVIYANI KHUSNA , PRASETYA TAUFIK ADHI , ROSHITAFANDI DHELA APRILYANDHA , SARTIKA HENI WAHYU , TRIJOKO TRIJOKO 
Published: April 2023

Abstract. Febiansi D, Rahmayanti F, Kurnia RN, Silmi MA, Dewi AK, Millaty NK, Prasetya TA, Roshitafandi DA, Sartika HW, Trijoko. 2018. Species diversity of gastropods (Cypraeidae and Conidae) at Krakal Beach, Gunungkidul, Yogyakarta, Indonesia. Ocean Life 2: 27-32. Krakal is a beach in Gunungkidul, Yogyakarta, Indonesia which has white sand and coral substrate in the intertidal zone. Cypraeidae and Conidae are families of gastropods found quite varied in the intertidal zone of Krakal Beach. The purpose of this research was to discover the diversity of Cypraeidae and Conidae families in the intertidal zone of Krakal Beach, Gunungkidul, Yogyakarta. The research was conducted on May 24, 2014 and May 25, 2017. The ecological parameters recorded were 26,5oC for temperature in 2014 and 26oC for temperature in 2017 , ±3.35% for salinity in 2014 and ±3,6% for salinity in 2017, 7.7 for pH. in 2014 and 7 for pH in 2017. The samples were collected using purposive sampling method, and specimens were identified by determining the morphological characteristics of the shell. This study found 5 species of Cypraeidae family in the intertidal zone of Krakal Beach, those are Cypraea annulus, Cypraea bouteti, Cypraea moneta, Cypraea caputserpentis and Cypraea lynx. While for family Conidae 5 species were found, those are Conus coronatus, Conus ebraeus, Conus capitaneus, Conus botulinus, and Conus fergusoni.