bluuebunny/crossref_metadata_2025_split huggingface dataset:
Value of triglyceride glucose-body mass index in predicting nonalcoholic fatty liver disease in individuals with type 2 diabetes mellitus
Authors: Qian Xiaoyi , Wu Wenwen , Chen Boyang , Zhang Simin , Xiao Chunmei , Chen Long , Chen Jun , Ke Lingli , He Meian , Li Xiulou 
Published: January 2025

BackgroundThere is limited data on the association between TyG-BMI and NAFLD in patients with Type 2 Diabetes Mellitus (T2DM). The magnitude of risk prediction and predictive efficacy of TyG-BMI for T2DM with NAFLD remains unclear.ObjectiveTo examine the association of TyG-BMI with NAFLD in T2DM patients and assess the effectiveness of screening using the TyG-BMI index.MethodsWe conducted a retrospective analysis of clinical data from 602 T2DM patients at an enterprise health lodge from September 2021 to November 2022. Patients were categorized into two groups: T2DM alone (n=250) and T2DM with NAFLD (n=352). The Mann-Whitney U test was used for comparing non-normally distributed continuous data between groups, while the Chi-square test was used for categorical data. Logistic regression analysis was performed to evaluate the effect of BMI, TyG index, and TyG-BMI index on NAFLD. The ROC curve was used to assess the predictive efficacy of the TyG-BMI index for NAFLD in T2DM patients.ResultsBMI predicted the development of NAFLD in T2DM patients with an area under the receiver operating characteristic (ROC) curve of 0.792 (95% CI 0.757-0.828), and the optimal cutoff value was 25.22, with 72.2% sensitivity and 71.6% specificity; The area under the receiver operating characteristic (ROC) curve of the TyG index to predict the development of NAFLD in patients with T2DM was 0.755 (95% CI 0.716-0.794), and the optimal cutoff value was 8. 945, with a sensitivity of 80.1% and a specificity of 59.2%; The area under the receiver operating characteristic (ROC) curve of TyG-BMI index to predict the development of NAFLD in T2DM patients was 0.852, (95% CI 0.822-0.882), and the optimal cutoff value was 227.385, with a sensitivity and specificity of 80.1% and 59.2%, respectively.ConclusionsThe TyG-BMI index is a significant predictor of comorbid NAFLD in T2DM patients and provides better screening performance than BMI alone. The TyG-BMI index shows promise as an early screening tool for NAFLD in T2DM patients.
Association between platelet count and 30-day in-hospital mortality among intensive care unit patients with sepsis: a multicenter retrospective cohort study
Authors: Wang Jun , Zhou Pan , Li Xin , Zhou Li , Deng Zhe 
Published: January 2025

BackgroundThe relationship between platelet count and sepsis outcomes in intensive care units (ICUs) requires comprehensive investigation through large-scale multicenter studies.MethodsIn this multicenter retrospective cohort study, we analyzed 17,977 sepsis patients from 208 U.S. hospitals (2014–2015) using the eICU Collaborative Research Database v2.0. Analyses were adjusted for demographics, clinical parameters, comorbidities, and treatments. Generalized additive models and two-piecewise linear regression were used to assess the relationship between platelet count and mortality.ResultsA U-shaped relationship was identified with an inflection point at 176 × 10⁹/L. Below this threshold, each 10 × 10⁹/L increase in platelet count was associated with a 6% decrease in mortality risk (adjusted OR 0.94, 95% CI 0.93–0.95, p &lt; 0.0001), while above it, each 10 × 10⁹/L increase was associated with a 1% increase in mortality risk (adjusted OR 1.01, 95% CI 1.00–1.01, p = 0.0153).ConclusionThis large-scale, multicenter retrospective study has made a significant contribution to understanding the association between platelet count and mortality in patients with sepsis in intensive care units. We identified a critical threshold of 176 × 109/L for platelet count and demonstrated a distinct U-shaped relationship with 30-day in-hospital mortality, providing valuable reference criteria for clinical risk stratification.
Prevalence and incidence of celiac disease in patients with rheumatoid arthritis: a case-control study based on the RECORD cohort
Authors: Sakellariou Garifallia , Schiepatti Annalisa , Zanetti Anna , Montecucco Carlomaurizio , Biagi Federico , Scirè Carlo Alberto 
Published: January 2025

BackgroundThe reported prevalence of coeliac disease (CD) in rheumatoid arthritis (RA) is variable.ObjectiveTo evaluate the prevalence and incidence of CD in RA and controls.DesignCase-control study on administrative data.MethodsThe RECord linkage On Rheumatic Disease database (administrative data, 2004–2013) was used to retrieve patients with RA and age and sex-matched controls. Prevalence and incidence of CD were calculated and stratified according to age, gender, and calendar year.ResultsThe cohort included 346,956 subjects (mean age 59.9 (14.5), 70.7% females), of which 70,061 RA and 276,895 controls. Median follow-up was 9 years (IQR 9–9). The prevalence of CD was higher in RA (171/70,061 = 0.24% (0.2–0.3%) vs 398/276895 = 0.14% (0.1–0.2%), p &lt; 0.001). The prevalence of CD among females with RA was increased compared to controls (0.3% vs 0.08%, p &lt; 0.001), but was not increased in males with RA. The incidence was higher in RA and remained stable throughout the observation period.ConclusionThe prevalence and incidence of CD were increased in RA, particularly in females.
The impact of COVID-19 pandemic on nosocomial infections in the cardiac care unit of a non-epidemic hospital in China
Authors: Liao Xiang , Wu Wei , Zhang Lijuan , Zhang Zheng , Zheng Chengrong , Qiu Xincheng , Xin Chao , Jin Zhitao 
Published: January 2025

BackgroundCOVID-19 is generally believed to increase the risk of nosocomial infections, however, there is a gap in relevant researches on critically ill patients in cardiac care units (CCU).MethodThis cross-sectional research was conducted in a tertiary-level non-epidemic hospital of Beijing, capital of China. The nosocomial infection rates of CCU were assessed prior to and during the of COVID-19 outbreak.ResultsDuring the COVID-19 pandemic, the overall incidence of nosocomial infections decreased by 20.6-percent compared with the pre - pandemic period. Specifically, the total nosocomial infection rate during the COVID-19 pandemic (p = 0.04) decreased by 20.6%. Among various types of CCU-acquired nosocomial infections, the rates of pneumonia, urinary tract infection (UTI), bloodstream infection (BSI), gastrointestinal infection, and skin infection decreased by ranges from 4.7 to 100% during the COVID-19 pandemic. Meanwhile, a 1.5-percent increase in ventilator-associated events (VAEs) was observed during the COVID-19 pandemic.ConclusionDuring the COVID-19 pandemic, stricter implementation of infection control protocols appears to reduce nosocomial infections in CCU.
Assembly mechanisms, not species pool, shape β-diversity of soil methanotrophic communities in steppes of China
Authors: Kou Yongping , Feng Zhe , Li Huan , Liu Yanjiao , Xu Lin , Li Xiangzhen 
Published: January 2025

IntroductionOne of the central aims in ecology is elucidating the mechanisms that shape community diversity. While biodiversity patterns across geographical gradients are often attributed both to local assembly processes and regional species pools, the distinct roles of these factors in shaping soil aerobic methanotrophic diversity remain underexplored.MethodsUsing amplicon sequencing and bioinformatics analysis, this study focuses on comparing the relative importance of species pool and community assembly processes in shaping soil methanotrophic communities across three distinct plateaus in China: the Loess Plateau, the Qinghai-Tibetan Plateau, and the Inner Mongolian Plateau. Each of these plateaus includes three distinct steppe habitats: desert, meadow, and typical steppe.ResultsOur findings reveal that pmoA beta (β)-diversity followed a distance-decay pattern, which declined with geographical distance at different rates depending on the steppe type and area, potentially due to diverse mechanisms of community assembly. Moreover, a decoupling between β-diversity and gamma-diversity observed, suggesting that local community assembly mechanisms primarily account for variations in β-diversity patterns. Furthermore, the relative significance of these assembly processes (e.g., dispersal limitation, drift, environmental filtering, and biotic interactions) varies according to spatial scales and steppe types. Notably, the differential environmental conditions (such as soil pH, yearly average temperature, and precipitation) across scales and steppe habitats primarily modulate the intensity of these assembly processes, thereby influencing β-diversity.ConclusionIn summary, our study emphasizes the crucial role of local community assembly in changing soil methanotrophic β-diversity’s geographical patterns, highlighting the significance of a nuanced understanding of these processes for effective conservation and management strategies.
Comparative microbial metagenomic analysis of drinking water plants and wastewater treatment plants in Istanbul
Authors: Demirci Mehmet , Çubuk Cankut , Dasdemir Ferhat , Saribas Abdulkerim Suat , Balcıoglu Esra Billur , Ozbey Dogukan , Yorulmaz Dogu , Olmez Hanci Tugba , Basa Safak , Kocazeybek Bekir Sami 
Published: January 2025

IntroductionWastewater treatment plants (WWTPs) and drinking-water treatment plants (DWTPs) are critical for public health due to the potential risks posed by microorganisms that may persist after treatment. The aim of this study was to detect the microbiome profiles of waters from both DWTPs and WWTPs under the Istanbul Water and Sewerage Administration (ISKI), identify the antimicrobial resistance profiles in all these facilities, and observe the differences in the microbiome between the inlet and outlet of different WWTPs.MethodsA total of 52 samples were examined, comprising 18 samples from DWTPs and 34 samples from WWTPs. All water samples underwent pre-isolation filtration. DNA isolation was conducted using filter material, followed by sequencing on a NovaSeq 6000 instrument. Kraken2 tools and R scripts were used for statistical analysis and data visualization.ResultsThe microbial metagenomic analysis identified 71 phyla, 113 classes, 217 orders, 480 families, and 1,282 genera across all samples. There were unclassified microbes (53.14% vs. 58.75%), Eukaryota (3.64% vs. 3.5%), Archaea (0.08% vs. 0.03%), bacteria (42% vs. 36.25%), and viruses (0.02% vs. 0.04%) in the raw water and ozonation unit outlet of DWTPs. The inlet and outlet of WWTPs showed unclassified microbes (52.68% vs. 59.62%), Eukaryota (0.6% vs. 1.72%), Archaea (0.26% vs. 0.15%), bacteria (46.43% vs. 38.43%), and viruses (0.05% vs. 0.04%). No statistically significant results were found in the analysis of raw waters collected from DWTPs and samples taken from the ozonation unit outlet—from the phylum level to the genus level (p &gt; 0.05). The inlet and outlet points of WWTPs showed no statistically significant results from the phylum to species levels (p &gt; 0.05). The most detected genera were Desulfobacter (4.82%) in preliminary WWTPs, Thauera (1.93%) in biological WWTPs, Pseudomonas (1.44%) in advanced biological WWTPs, Acidovorax (1.85%) in biological package WWTPs, and Pseudomonas (11.55%) in plant-based WWTPs. No antimicrobial resistance gene markers were detected in water samples from raw water inlets and ozonation unit outlets from DWTPs, membrane wastewater recovery plants, or ultraviolet (UV) recycling facilities. The ANT(3″), Erm, and Sul resistance gene markers were detected in all raw WWTPs samples.DiscussionThere were no significant microbial risk differentiation between biological WWTPs and advanced biological WWTPs. The data could serve as preliminary information for future research. More extensive studies are needed, with multiple sample tracking in these facilities and their feeding basins.
Alpha 1-antitrypsin mitigates salt-sensitive hypertension in juvenile mice by reducing diacylglycerol concentrations and protein kinase C activity in kidney membranes
Authors: Dogan Yunus E. , Bala Niharika , Galban Erika S. , Lewis Russell L. , Denslow Nancy D. , Song Sihong , Alli Abdel A. 
Published: January 2025

IntroductionRecombinant alpha-1 antitrypsin (AAT) therapy has been shown to have beneficial effects to mitigate the progression of various diseases. Here, we hypothesized that administration of pharmaceutical-grade human AAT (hAAT) is effective in mitigating hypertension induced by salt-loading in juvenile mice by reducing the concentration of diacylglycerols (DAGs) and activity of protein kinase C (PKC) in the kidney.MethodsFour-week old 129Sv mice were salt-loaded to induce hypertension and then administered hAAT or vehicle.ResultsAdministration of hAAT was found to significantly reduce high blood pressure in both the active and inactive cycles of the 129Sv hypertensive mice. A lipidomic analysis showed decreased concentrations of multiple diacylglycerols in kidney cortex membrane fractions from mice treated with hAAT compared to vehicle. PKC activity was less in the 129Sv mice that received hAAT compared to vehicle. Western blotting and immunohistochemistry analysis showed the density of the sodium-potassium-chloride co-transporter (NKCC2) was significantly reduced in kidney cortex membrane fractions of juvenile mice that received hAAT compared to vehicle.ConclusionTaken together, this study demonstrates a new protective effect of hAAT in normalizing blood pressure after the development of saltinduced hypertension in juvenile mice in a mechanism involving a decrease in NKCC2 membrane expression, presumably due to decreased levels of DAGs in the plasma membrane and a subsequent decrease in PKC activity.
Correlation of muscle strength, information processing speed and cognitive function in the elderly with cognitive impairment——evidence from EEG
Authors: Xin Xin , Liu Qing , Jia Shuqi , Li Shufan , Wang Peng , Wang Xingze , Wang Xing 
Published: January 2025

ObjectiveThis study investigates the interplay between muscle strength, information processing speed, EEG-specific biomarkers, and cognitive function in elderly individuals with cognitive impairments, emphasizing the mediating roles of information processing speed and EEG-specific biomarkers.MethodA cross-sectional study design was employed to recruit 151 elderly participants. The participants underwent grip strength and 30-s sit-to-stand tests to assess muscle strength, completed the Trail Making Test part A (TMT-A) and the Symbol Digit Modality Test (SDMT) to evaluate information processing speed, and utilized the Montreal Cognitive Assessment (MOCA) to gauge cognitive function. Additionally, EEG signals were recorded for 5 min to capture neural activity.ResultsThe difference in information processing speed among elderly individuals with varying degrees of cognitive impairment was statistically significant (p &lt; 0.001). A significant negative correlation was observed between the MoCA score and the time consumption of TMT-A (r = −0.402, p &lt; 0.01), and a significant positive correlation was found between the MoCA score and the SDMT score (r = 0.609, p &lt; 0.01). Grip strength was negatively correlated with the time consumption of TMT-A (r = −0.336, p &lt; 0.01) and positively correlated with the SDMT score (r = 0.336, p &lt; 0.01). A significant negative correlation was found between the 30-s sit-to-stand test and the time consumption of TMT-A (r = −0.273, p &lt; 0.01), and a significant positive correlation was observed between the 30-s sit-to-stand test and the SDMT score (r = 0.372, p &lt; 0.01). Additionally, we observed that the α1 power value indicators were significantly correlated with the MoCA score, the time consumption of TMT-A, and the SDMT score (all p &lt; 0.01). The α1 power values at F7 + F8 and T5 + T6 were identified as sensitive EEG indicators for muscle strength and information processing speed. The EEG-specific indicators (B = 0.019, 95% CI: 0.003, 0.047) and information processing speed (B = 0.137, 95% CI: 0.096, 0.292) were found to partially mediate the relationship between grip strength and MoCA scores, with information processing speed exerting a stronger mediating effect.ConclusionSpecific patterns were observed in the EEG of elderly individuals with cognitive impairments, which could objectively assess the risk of cognitive decline in this population. Muscle strength, information processing speed, and EEG-specific biomarkers were closely associated with cognitive function in elderly individuals. The potential pathway of interaction—muscle strength → EEG-specific biomarkers → information processing speed → cognitive function—provides valuable insights into advancing the field of cognitive research in the elderly.
Association of serum neurofilament light chain with cognitive impairment: findings from the National Health and Nutrition Examination Survey
Authors: Meng Tianjiao , Fei Qinwen , Lv Tian , Chen Shiqin 
Published: January 2025

BackgroundSerum Neurofilament Light chain (NfL) is a promising biomarker of neuronal damage, used to assess the extent of neuronal injury and neurodegeneration, and it is widely applied in the diagnosis of neurodegenerative disease and monitoring disease progression. This article aims to determine whether serum NfL associated with cognitive level.MethodsUsing NHANES data, we conducted an analysis of cognitive test results for 450 adults aged 60 years and older and examined their correlation with serum NfL levels. When exploring the association between cognitive test scores and serum NfL levels, regression models and restricted cubic spline (RCS) regression models were employed to adjust for potential confounding factors. The least absolute shrinkage and selection operator (LASSO) regression was applied for identifying key cognitive impairment factors, which was then included in the establishment of a risk prediction nomogram model, with the receiver operating characteristic (ROC) curve being built to evaluate its discriminatory power for cognitive impairment.ResultsIt was found that there is a strong positive correlation between serum NfL levels and both low total cognitive function (total-CF) OR: 1.028 (95%CI = 1.015–1.041 p &lt; 0.001) and low Digit Symbol Substitution Test (DSST) OR: 1.026 (95%CI = 1.003–1.050, p = 0.027). Furthermore, using the RCS model, we observed a linear trend in the relationship between NfL and low total-CF. The nomogram model based on NfL identified by LASSO regression displayed a considerable predicative value for low total-CF, with an area under the curve [AUC = 85.6% (81.6–89.3%)].ConclusionThere is a strong correlation between serum NfL levels and cognitive function, especially DSST, which reflects attention and information processing abilities, as well as overall cognitive function, but not memory and language fluency. Thus, NfL may serve as a serum biomarker for dementia monitoring.
Influential publications in sudden hearing loss: a bibliometric and visual synopsis of the top 100 cited articles
Authors: Di Xueshi , Liang Junjie , Wang Xinru , Bai Xue , Zhang Chongyang , Pan Ting , He Tiantian , Bai Peng 
Published: January 2025

BackgroundSudden hearing loss (SHL) is a prevalent emergency in otolaryngology. Despite its frequency, there is a lack of econometric analysis and visualisation of the most significant SHL research literature. This study aims to provide a comprehensive overview and explore the characteristics of the 100 most cited articles in SHL through bibliometric analysis.Materials and methodsThe Web of Science Core Collection (WOSCC) was used to identify the 100 most cited SHL articles from 1999 to 2024. Tools such as CiteSpace and VOSviewer were employed to visualise data on countries, institutions, authors, co-cited authors, journals, co-cited journals, co-cited references, and keywords.ResultsThe citations of the 100 most cited articles ranged from 59 to 760, with publications spanning from 1999 to 2021 and peaking in 2005. The most cited article was authored by Schwartz SR. The majority of these articles originated from the United States. Key themes identified include treatment options for SHL, with prominent keywords such as deafness, therapy, and dexamethasone.ConclusionThis study identified the highly cited literature in SHL research, revealing a primary focus on treatment options. These findings provide crucial insights into the research hotspots and frontiers in the field of SHL.
Single-center experience with ultra-early cranioplasty within 3 weeks after decompressive craniectomy
Authors: Zhao Lei , Zhang Gengshen , Liu Xiaomeng , Yang Lijun , Tang Kai , Wu Jianliang 
Published: January 2025

BackgroundThe optimal timing of cranioplasty (CP) after decompressive craniectomy (DC) is inconclusive. This article aims to investigate the effect of different timing of CP on the neurologic prognosis of patients, and to explore the feasibility and safety of ultra-early CP (within 3 weeks) following DC.MethodsThe duration time of surgery, intraoperative bleeding volume, surgery-related complications, and activities of daily living (ADL) scores were retrospectively analyzed in 23 patients underwent ultra-early CP performed within 3 weeks, and compared with 136 patients with non-ultra-early CP performed within the same time period.ResultsThe mean duration time of surgery in the ultra-early group was significantly shorter than that in the non-ultra-early group. ADL scores were significantly lower in the ultra-early group than in the non-ultra-early group both before and 1 month after CP, but there was no statistically significant difference in ADL scores between the two groups at long-term follow-up. The overall incidence of surgery-related complications was 17.39% (4/23) in the ultra-early group and 14.71% (20/136) in the non-ultra-early group, and there was no statistically significant difference in the comparison between the two groups (p = 0.739).ConclusionBoth ultra-early and non-ultra-early CP can significantly improve the neurological prognosis of patients. Ultra-early CP can significantly shorten the length of surgery and does not increase the incidence of surgery-related complications, which has a certain degree of safety and feasibility, and can be popularized under the premise of strict screening of indications, but further research is still needed.
Near vision assessment for adults using the NIH Toolbox
Authors: Finley John-Christopher A. , Slotkin Jerry , Nowinski Cindy J. , Bedjeti Katy , Volpe Nicholas , Weintraub Sandra , Gershon Richard 
Published: January 2025

IntroductionThe National Institutes of Health (NIH) Toolbox Near Visual Acuity Test is a novel digitized measure designed to provide an assessment of near vision in a time-and cost-effective manner. This study is the first to report the psychometric properties of the NIH Toolbox Near Visual Acuity Test in a sample of community-dwelling middle-aged and older adults.MethodsNinety-eight adults (ages 40–81) completed the tablet-based near vision test and the gold standard chart-based near vision test. Performance on the tablet-and chart-based near vision tests was expressed in logarithmic units. Chart-and tablet-based administration order was counterbalanced. To assess test–retest reliability, the NIH Toolbox Near Visual Acuity Test was administered twice within the same day. Additionally, two equivalent versions of the chart-based test were randomly assigned to participants.ResultsAnalyses revealed that test–retest reliability of the NIH Toolbox Near Visual Acuity Test was good (intraclass correlation = 0.87, p &lt; 0.001). Concurrence between the NIH Toolbox Near Visual Acuity Test and gold standard chart-based test was also good (r = 0.79, p &lt; 0.001).DiscussionFindings provide support for the reliability and validity of the NIH Toolbox Near Visual Acuity Test as a near vision assessment for middle-aged to older adult populations. With further research, the integration of this test within the widely used NIH Toolbox may provide a more efficient means to understanding how near visual acuity influences neurocognitive test performance and brain function in middle-aged to older adult populations.