bluuebunny/crossref_metadata_2025_split huggingface dataset:
Molecular Etching‐Derived High‐Brightness NIR‐II Gold Nanoclusters for High‐Resolution Bioimaging and Photothermal Therapy
Authors: Tian Fangzheng , Li Siyu , Yang Xue , Fan Kai , Zhou Mei , Gao Duyang , Hu Dehong , Ju Shenghong 
Published: January 2025

AbstractGlutathione‐capped gold nanoclusters (GSH‐Au NCs) with second near‐infrared (NIR‐II, 1000–1700 nm) fluorescence have received increasing interest in biomedical applications. However, conventional aqueous synthesis of GSH‐Au NCs results in low NIR‐II absolute fluorescence quantum yield (≈0.27%) and limited renal clearance efficiency (≈70%), which restricts its clinical applications. This study reports a GSH‐etching post‐synthesis method to selectively convert nonfluorescent GSH‐Aun NCs (n > 25) into fluorescent GSH‐Au25 NCs (eGSH‐Au NCs). This molecular etching process decreases the size of the NCs from 3.3 to 2.0 nm and afforded 37% increase in NIR‐II absolute fluorescence quantum yield and 11.9% enhancement in renal clearance efficiency. The optimized eGSH‐Au NCs facilitates whole cerebrovascular imaging through the scalp and skull, tumor vasculature imaging with a resolution of 40.8 µm, dynamic tumor perfusion imaging with a signal‐to‐background ratio of 10.5, and enhanced lymphatic vessel and lymph node imaging. Additionally, eGSH‐Au NCs exhibit superior photothermal properties, achieving almost 100% tumor growth inhibition in Hepa1‐6 tumor‐bearing mice. This study presents a novel strategy to improve the bioimaging and therapeutic performance of NIR‐II Au NCs, thus advancing their clinical translation.
Enhanced Biological Behavior and Photothermal Antibacterial Performance of TiNbCTx MXene Modified Mesoporous Bioactive Glass Nanocomposites
Authors: Yan Siqing , Ma Qian , Wen Cuilian , Luo Lijin , Jin Junhao , Li Xiong , Fang Yuanxing , Sa Baisheng 
Published: January 2025

AbstractMesoporous bioactive glasses (MBGs) are gaining recognition in bone tissue engineering for their osteoblast differentiation‐inducing properties and customizable structures. However, the challenge of peri‐implantitis has hindered their broader application. To address this, double transition metal TiNbCTx MXene acted as near‐infrared (NIR) photothermal agent, has been integrated with MBG nanospheres to develop novel multifunctional TiNbCTx/MBG (TNC/MBG) nanocomposites in this work. The results demonstrate that the TNC/MBG composites feature uniform mesoporous spherical MBG nanoparticles on TiNbCTx nanosheets, boasting a significantly enhanced specific surface area of up to 444.74 m2 g−1 and a more negative zeta potential than pristine MBG. Importantly, the TNC/MBG nanocomposites can effectively promote apatite formation, as well as the proliferation and viability of MC3T3‐E1 cells. Moreover, it is highlighted that the TNC/MBG nanocomposites display remarkable photothermal conversion efficiency and stability, leading to over 95% antibacterial inhibition rates against both S. aureus and E. coli under NIR irradiation. These findings offer an appealing strategy to develop multifunctional TNC/MBG nanocomposites with enhanced biological activity and robust antibacterial properties, which shows great potential for various biomedical applications.
Reducing Parasitic Loss and Deep Defect Formation via Copper Doping Toward Highly Efficient Sb2Se3 Solar Cells
Authors: Mo Anming , Yang Binxin , Lu Xinzhou , Duan Yanjun , Liang Xiaoyang , Zhang Zheng , Guo Yingnan , Li Zhiqiang 
Published: January 2025

AbstractAntimony selenide (Sb2Se3) has great potential as a light‐absorbing layer in thin‐film photovoltaics because of its excellent photoelectric properties and superior stability. Presently, high‐efficiency Sb2Se3 solar cells use a heterojunction consisting of a p‐type Sb2Se3 absorber and an n‐type CdS layer. The power conversion efficiency (PCE) of Sb2Se3 solar cells is restricted by the low carrier concentration in the CdS layer, complex intrinsic deep defects of Sb2Se3, and unsuitable energy level band alignment in the junction. This paper presents a copper (Cu) doping strategy that achieves a synergistic doping effect, enabling controllable doping in both the n‐type CdS layer and p‐type Sb2Se3 absorber. First, proper Cu doping significantly enhances the short‐wavelength transmittance of CdS films and increases their n‐type carrier concentration. The Vbi in the CdS/Sb2Se3 heterojunction improves from 521 to 751 mV. Second, a post‐annealing process is performed to facilitate Cu diffusion from the CdS layer to the Sb2Se3 absorber. This approach successfully passivates intrinsic deep defect E2 and reduces the interfacial trap‐assisted nonradiative recombination losses. As a result, the Cu‐doped Sb2Se3/CdS solar cell presents a PCE of 10.23%, representing a 40% enhancement in PCE compared to the undoped CdS/Sb2Se3 heterojunction device.
An Endothelium‐Mimicking, Healable Hydrogel Shield for Bioprosthetic Heart Valve with Enhanced Intravascular Biocompatibility
Authors: Maitusong Miribani , Ren Tanchen , Gao Ying , Hong Xiaoqian , Deng Kaicheng , Yao Lin , Cheng Si , Zhou Xuhao , Lin Ying , Tian Ge'er , Zhao Jing , Li Peng , Liu Xianbao , Wang Jian'an 
Published: January 2025

AbstractBioprosthetic heart valves (BHVs) for transcatheter replacement often face deterioration due to thrombosis, inflammation, and calcification, which are irreversible. Here, a multidimensional endothelium‐mimicking healable hydrogel shielded BHV that not only withstand the complex valvular physiological and hemodynamic environment but also able to reverse damage‐induced structural degeneration by in situ healing is proposed. Polydopamine/selenocystamine nanoparticles with photothermal effect are embedded to achieve light‐triggered healing and catalytic nitride oxide generation in polyvinyl alcohol hydrogel coating on BHV surface. Additionally, platelet inhibitor Tirofiban is encapsulated in the hydrogel shield to block acute coagulation cascade in early stage after implantation. A rodent intravascular leaflet‐like implantation model is developed to reveal the long‐term hemocompatibility of BHVs in abdominal aorta. The shielded BHVs exhibit enhanced antithrombotic properties, reduced inflammation, superior endothelialization, and improved vascular patency. Transcriptome analysis indicates better endothelial functions on shielded BHVs. Moreover, the endothelium‐mimicking hydrogel shield maintains both mechanical properties and biological functions after healing, facilitated great hemocompatibility and fast re‐endothelialization. Collectively, the multidimensional endothelium‐mimicking strategy provides new insight for preventing and reversing BHV damage instead of solely replacement.
A Novel Full‐Band Microwave Absorber Based on Scattering Enhanced Prism‐Honeycomb Nested Structure
Authors: Liu Shaokang , Zhou Yanming , Zhang Fangxin , Wang Qingshan , Zhao Xing , Chao Bin , Wu Haihua 
Published: January 2025

AbstractWith advancements in radar detection technology, electromagnetic stealth has garnered significant attention in military applications. Traditional electromagnetic absorbers typically focus on tuning electromagnetic parameters; however, they are often limited by material constraints, resulting in effective absorption only within narrow frequency bands. This work presents a novel prism‐honeycomb nested microwave absorbing structure, inspired by the scattering phenomenon of light waves in a prism, which utilizes an enhanced scattering effect. The varying impedances of electromagnetic waves (EMWs) in different media lead to transmission and reflection that adhere to Snell's law at the interfaces. To optimize the scattering effect, the inner prism is filled with a high transmittance material, while the outer honeycomb structure incorporates a material with high dielectric loss. Consequently, electromagnetic waves experience significant attenuation within the unit. Despite a thickness of only 7 mm, this structure achieves over 90% EMW absorption across a broad frequency range of 1–18 GHz. Additionally, the honeycomb structure exhibits excellent mechanical load‐bearing capacity. The nesting of the prism further enhances support points, resulting in a compressive strength of 16.4 MPa. This innovative design not only facilitates full‐band absorption but also provides high mechanical load‐bearing capabilities, offering valuable insights for applications in electromagnetic stealth and camouflage.
Negative Swelling and Mechanical Self‐Enhancement TAFe@PVA Photothermal Hydrogel Mediated Via Semi‐Crystallization for Medical Implants
Authors: Zhang Qingrong , He Sicen , Mei Ailian , Xia Wei , Cao Yunchang , Zhang Zeying , Jia Jiezhi , Yang Jiacai , Li Jiangfeng , Luo Gaoxing , Li Zheng 
Published: January 2025

AbstractMedical implants, important consumables, significantly promote patients’ healthcare, but still face challenges of foreign body responses and bacterial infection. Hydrogels can be ideal alternative materials, however, a few of them can meet the requirements. Herein, a TAFe@PVA photothermal hydrogel integrating with negative swelling, long‐term stability, antibacterial, anti‐adhesion, and tissue mechanical matching is developed to solve these issues. The TAFe@PVA hydrogel is crosslinked by H‐bonds and microcrystal domains which both can be enhanced by cations or anions based on Hofmeister effect, showing unique negative swelling and long‐term mechanical self‐enhancement performances in the physiological fluid. Attributing to self‐polymerization of tannic acid (TA) and negative swelling of polyvinyl alcohol (PVA) molecular networks, TAFe complexes can be strongly locked in PVA molecular networks, reaching long‐term photothermal stability. The TAFe@PVA hydrogel also exhibits great biocompatibility, anti‐oxidation, anti‐adhesion, and anti‐bacterial performances, comparing to the traditional implant material. Since the TAFe@PVA hydrogel can better match with skin tissues, fewer macrophages and myofibroblasts are activated, which depresses unexpected foreign body responses. Finally, the TAFe@PVA hydrogel as the implant can effectively solve abdominal adhesions after abdominal operation and promote defects healing. This study introduces a promising hydrogel implant, which potentially extends hydrogels to wider medical applications.
Leveraging Optical Anisotropy of the Morpho Butterfly Wing for Quantitative, Stain‐Free, and Contact‐Free Assessment of Biological Tissue Microstructures
Authors: Kirya Paula , Mestre‐Farrera Aida , Yang Jing , Poulikakos Lisa V. 
Published: January 2025

AbstractChanges in the density and organization of fibrous biological tissues often accompany the progression of serious diseases ranging from fibrosis to neurodegenerative diseases, heart disease and cancer. However, challenges in cost, complexity, or precision faced by existing imaging methodologies and materials pose barriers to elucidating the role of tissue microstructure in disease. Here, we leverage the intrinsic optical anisotropy of the Morpho butterfly wing and introduce Morpho‐Enhanced Polarized Light Microscopy (MorE‐PoL), a stain‐ and contact‐free imaging platform that enhances and quantifies the birefringent material properties of fibrous biological tissues. We develop a mathematical model, based on Jones calculus, which describes fibrous tissue density and organization. As a representative example, we analyzed collagen‐dense and collagen‐sparse human breast cancer tissue sections and leverage our technique to assess the microstructural properties of distinct regions of interest. We compare our results with conventional Hematoxylin and Eosin (H&E) staining procedures and second harmonic generation (SHG) microscopy for fibrillar collagen detection. Our findings demonstrate that our MorE‐PoL technique provides a robust, quantitative, and accessible route toward analyzing biological tissue microstructures, with great potential for application to a broad range of biological materials.
MicroVasculoid‐Chip: A 3D Self‐Assembled Human Microcirculation‐on‐a‐Chip Model Reveals Enhanced Lymphangiogenic Lung Cancer‐Induced Vessel Remodeling and Invasion
Authors: Abreu Catarina M. , Lima Ana C. , Neves Nuno M. , Kundu Subhas C. , Reis Rui L. , Caballero David 
Published: January 2025

AbstractThe microvasculature within the tumor microenvironment is crucial for the invasion and dissemination of cancer cells throughout the body. Given its importance and dynamic behavior, several microfluidic models have been developed to study microvascular infiltration and its interaction with cancer cells. However, most of these models primarily focus on blood vessels and use microfluidic channels coated with endothelial cells, which fail to replicate near‐physiological conditions. To address this limitation, the MicroVasculoid‐chip is introduced, a novel human microcirculation‐on‐a‐chip model that features self‐organized 3D blood and lymphatic microvasculature alongside tumor spheroids. This innovative platform enables the exploration of interactions between multi‐cellular tumors and both microvascular networks. Using lung cancer as a case study, how tumor‐released mediators influence vessel morphology is investigated in relation to tumor invasion capacity, identifying molecular factors potentially associated with microvascular remodeling. Overall, the MicroVasculoid‐chip provides a robust tool for investigating and modeling critical events of cancer neo‐vascularization, for deciphering fundamental mechanisms of cancer cell invasion into the microvasculature, and for future drug screening applications.
Integrated Biosensor with Microfluidic Chip and Microwave Sensor Chip for Cell Separation and Detection
Authors: Li Zhonghao , Wang Yanxiong , Yang Sen , Chen Qianlong , Li Yuanbo , Liang Junge , Zhou Xiaoman , Fan Qigao , Jiang Yanfeng , Wang Lei , Qiang Tian 
Published: January 2025

AbstractIn this work, an integrated biosensor consisting of spiral microfluidic array and microwave sensors is proposed for simultaneous separation and detection of cells. The biosensor integrated by plasma processing technology is fabricated by soft lithography and glass‐based IC process, which has the advantages of simple preparation, low cost, and reliable structure. In the field of clinical medicine, Escherichia coli (E. coli) is the causative agent of urinary tract infections, which leads to an increase in the number of white blood cells (WBCs) present in the urine. Different concentrations of E. coli and WBCs mixed solution are configured to perform biological cell experiments and the capability of the biosensor in separating and detecting WBCs is verified. Interdigital capacitors (IDCs) and split ring resonators (SRRs) are employed to detect the WBCs obtained by microfluidic array separation. The microfluidic array exhibits a WBC collection rate of 92.7%. The capacitance of the IDC and the resonant amplitude of the SRR exhibit a decrease of 51.36 pF and 0.34 dB, which demonstrates a satisfactory linearity of 0.96 and 0.98, respectively. Consequently, the integrated biosensor used to simultaneously separate and detect WBCs has the potential for the early diagnosis of urinary tract infections in clinical medicine.
Supporting Transition Resilience Among Newcomer Groups (STRONG): Examining effectiveness and acceptability in urban public schools
Authors: Santiago Catherine DeCarlo , Sosa Susana , Raviv Tali , Flores Roxanna , Donis Andrea , Jolie Sarah , Bustos Yvita , Elahi Saadia , Ford‐Paz Rebecca , Ramos Bianca , Cicchetti Colleen , Torres Stephanie , Zarzour Hadia , Kang Sungha 
Published: January 2025

AbstractThe Supporting Transition Resilience Of Newcomer Groups (STRONG; Hoover et al., 2019) program was developed to support mental health among newcomer refugee and immigrant students by (1) promoting positive adjustment during resettlement through a trauma‐informed, strengths‐based approach, contextualized to meet the needs of refugee and immigrant youth; and (2) improving access to services through school‐based programming. The purpose of this study was to examine the acceptability and effectiveness of STRONG on the mental health and resilience of refugee and immigrant students using a group randomized waitlist control design. A sample of 64 newcomer students (Mage = 13.9, SD = 3.11; 41% female) was recruited to participate in the STRONG program, representing 19 different countries of origin and diverse ethnicities (44% Latiné; 34% Asian; 13% Middle Eastern/North African; 8% African/Black). Additionally, teachers or administrators from each participating STRONG school completed interviews, while group facilitators (e.g., clinicians and bilingual teachers) were invited to participate in focus groups. This study provides preliminary evidence that STRONG supports newcomer mental health, with students in the immediate treatment group showing reductions in anxiety/depression and externalizing symptoms compared to the waitlist. Qualitative findings provide additional support for the acceptability and benefits of this intervention. However, coping efficacy unexpectedly decreased, and several interactions with school type (e.g., high school vs. elementary) emerged. Additional research is warranted to further evaluate this promising intervention for newcomer youth.
Critical reflection and action in response to an anti‐immigration context: What we can learn from migrant young adults from Latin America
Authors: Negrete Andrea , Ramirez‐Arellano Laura , Lucas Melissa , Hurd Noelle M. 
Published: January 2025

AbstractMigrant youth from Latin America who arrive in the United States are faced with a social and political context that dehumanizes migrants of color. These anti‐immigrant sentiments become reflected in federal and state policies that deny migrants rights to freedom and safety. The present paper examined how the U.S. immigration context informed migrant young adults' structural analysis of immigration policies and rhetoric (critical reflection) and actions to challenge exclusionary immigration‐related policies and rhetoric (critical action). We further examined facilitators and barriers to action. Semi‐structured interviews were conducted with migrant young adults from Latin America living in Virginia (N = 30; M = 20.93; SD = 2.03; 53% female). We employed constructivist grounded theory strategies to analyze the data. Findings showed that migrant young adults offered a range of structural and individual‐level attributions for unjust immigration policies. For some migrant young adults, their critical reflection informed decisions to engage in critical actions. Yet, many migrant young adults also noted constraints that impeded their engagement. By more thoroughly understanding migrant young adults' critical reflection and factors that may facilitate or impede action, researchers and practitioners may be better positioned to support migrant young adults who seek to dismantle systems of oppression.
Intranasal Calcitriol Accelerates Improvement of Sinonasal Inflammation and Olfactory Impairment in Mice After Cessation of Chronic Cigarette‐Smoke Exposure
Authors: Langerude Logan , McQuiston Alex , Atkinson Carl , Mulligan Jennifer K. 
Published: January 2025

ABSTRACTRationaleSmoking has been shown to be associated with circulating deficiencies in 25(OH)D3 and reduced sinonasal tissue levels of the active form of vitamin D, 1,25(OH)2D3. Given vitamin D's ability to reduce inflammation, we sought to examine if intranasal (IN) delivery of calcitriol [clinical analog of 1,25(OH)2D3] could reduce inflammation and improve disease severity in a murine model of chronic cigarette smoke‐induced sinonasal inflammation (CS‐SI).MethodsMice were exposed to CS 5 h/day, 5 days/week for 9 months, and then began IN calcitriol three times per week for 4 weeks. Micro‐CT was used to assess disease severity. Sinonasal tissues were collected for RNA‐seq analysis. Olfactory function was assessed using a T‐maze odorant avoidance sniff behavior test. Nasal lavage fluid (NALF) was used for cytology and cytokines analysis.ResultsQuantification of disease severity by micro‐CT showed IN calcitriol reduced opacification by 18%, as compared to smoke cessation alone, in which only a 5% reduction was noted. H&E analysis of NAFL demonstrated heightened neutrophil infiltration and neutrophil‐associated chemokines in CS‐SI mice, which was reduced with IN calcitriol treatment. RNA‐seq pathway analysis demonstrated that smoking was associated with odorant binding changes and that calcitriol treatment reduced neutrophil migration and inflammation. Lastly, IN calcitriol reversed olfactory loss caused in CS‐SI.ConclusionsIN delivery of calcitriol accelerates inflammatory resolution in the nose and olfactory mucosa after prolonged CS exposure. Furthermore, treatment was associated with improved olfactory function in mice CS‐SI, as such local delivery of calcitriol may serve as a novel treatment for modulating sinonasal inflammation.
The Impact of Sinus Surgery for Chronic Rhinosinusitis on Concomitant Depression and Anxiety Symptoms: A Systematic Review and Meta‐analysis
Authors: Cheah Xing Yi , Tan Claire Jing Wen , Yeo Brian Sheng Yep , Lim Nicholas E‐Kai , Tan Qian Wei , Teoh Marcus Zhe Xuan , Tan Benjamin Kye Jyn , Rawtaer Iris , Teo Neville Wei Yang , Charn Tze Choong 
Published: January 2025

ABSTRACTBackgroundBoth anxiety and depression are prevalent among patients with chronic rhinosinusitis (CRS) and associated with poorer outcomes following treatment for CRS. However, the impact of treatment on CRS on mental health remains uncertain. Therefore, this study seeks to evaluate if surgical intervention for CRS may alleviate comorbid depression and anxiety.MethodsPubMed, Embase, and Scopus databases were searched for retrospective and prospective cohort studies, cross‐sectional studies, and randomized controlled trials relating to CRS treatment using sinus surgery from inception to April 30, 2024, using the Population, Intervention, Comparison, and Outcomes (PICO) framework. Three blinded reviewers selected observational studies and randomized controlled trials investigating levels of depression and anxiety pre‐ and post‐surgical treatment of CRS. Eleven studies comprising 3067 patients were included, of which five studies were quantitatively analyzed. After which, data were extracted from included articles into a structured proforma and the Newcastle‐Ottawa Scale was used to evaluate study bias, following Preferred Reporting Items for Systematic Review and Meta‐Analyses (PRISMA) guidelines and a PROSPERO‐registered protocol (CRD42022351855). Meta‐analyses of the ratio of means were conducted in a random‐effects model.ResultsOverall, sinus surgery was associated with significant improvement in test scores of depression (ratio of means (ROM) = 1.47, 95% confidence interval [CI] = 1.03‒2.10), anxiety (ROM = 1.10, 95% CI = 0.81‒1.49), and quality of life markers, which are closely correlated to mental health outcomes.ConclusionsSinus surgery for CRS may improve mental health outcomes (both depression and anxiety) for patients.
Olfactory Cleft Opacification Improves With Intranasal Steroid Treatment and Is Correlated With Objective and Patient‐Reported Olfactory Outcomes
Authors: Workman Alan D. , Lerner David K. , Rathi Vinay K. , Douglas Jennifer E. , Kohanski Michael A. , Adappa Nithin D. , Palmer James N. 
Published: January 2025

Summary
In patients with severe olfactory and gustatory dysfunction, olfactory cleft opacification improves with expanded intranasal steroid treatment (EDS‐FLU) relative to placebo.
This is directly associated with objective and patient‐reported taste/smell improvement.