bluuebunny/crossref_metadata_2025_split huggingface dataset:
New insights into the poleward migration of tropical cyclones and its association with Hadley circulation
Authors: Anjana U. , Kumar Karanam Kishore 
Published: September 2023

AbstractRecent investigations have shown a robust signature of poleward migration of the tropical cyclone latitudes using observations and climate model simulations. Most of these studies invoked the role of the Hadley circulation (HC) expansion in the poleward shifting of tropical cyclones. However, none of these studies focused on the dissection of the zonally asymmetric HC into ascending and descending regions at regional scales, which holds the key in establishing the association between these two phenomena. Here, we are reporting the poleward migration of tropical cyclones and their association with ascending region boundaries of the HC at regional scales for the first time. The results emphatically show that the tropical cyclone latitudes as well as latitudes of maximum lifetime intensity vary in tandem with boundaries of the ascending region of the HC as compared to its descending region thus providing a vital clue on processes governing poleward migration of tropical cyclones.
Linking spontaneous and stimulated spine dynamics
Authors: Eggl Maximilian F. , Chater Thomas E. , Petkovic Janko , Goda Yukiko , Tchumatchenko Tatjana 
Published: September 2023

AbstractOur brains continuously acquire and store memories through synaptic plasticity. However, spontaneous synaptic changes can also occur and pose a challenge for maintaining stable memories. Despite fluctuations in synapse size, recent studies have shown that key population-level synaptic properties remain stable over time. This raises the question of how local synaptic plasticity affects the global population-level synaptic size distribution and whether individual synapses undergoing plasticity escape the stable distribution to encode specific memories. To address this question, we (i) studied spontaneously evolving spines and (ii) induced synaptic potentiation at selected sites while observing the spine distribution pre- and post-stimulation. We designed a stochastic model to describe how the current size of a synapse affects its future size under baseline and stimulation conditions and how these local effects give rise to population-level synaptic shifts. Our study offers insights into how seemingly spontaneous synaptic fluctuations and local plasticity both contribute to population-level synaptic dynamics.
An archaeal lid-containing feruloyl esterase degrades polyethylene terephthalate
Authors: Perez-Garcia Pablo , Chow Jennifer , Costanzi Elisa , Gurschke Marno , Dittrich Jonas , Dierkes Robert F. , Molitor Rebecka , Applegate Violetta , Feuerriegel Golo , Tete Prince , Danso Dominik , Thies Stephan , Schumacher Julia , Pfleger Christopher , Jaeger Karl-Erich , Gohlke Holger , Smits Sander H. J. , Schmitz Ruth A. , Streit Wolfgang R. 
Published: September 2023

AbstractPolyethylene terephthalate (PET) is a commodity polymer known to globally contaminate marine and terrestrial environments. Today, around 80 bacterial and fungal PET-active enzymes (PETases) are known, originating from four bacterial and two fungal phyla. In contrast, no archaeal enzyme had been identified to degrade PET. Here we report on the structural and biochemical characterization of PET46 (RLI42440.1), an archaeal promiscuous feruloyl esterase exhibiting degradation activity on semi-crystalline PET powder comparable to IsPETase and LCC (wildtypes), and higher activity on bis-, and mono-(2-hydroxyethyl) terephthalate (BHET and MHET). The enzyme, found by a sequence-based metagenome search, is derived from a non-cultivated, deep-sea Candidatus Bathyarchaeota archaeon. Biochemical characterization demonstrated that PET46 is a promiscuous, heat-adapted hydrolase. Its crystal structure was solved at a resolution of 1.71 Å. It shares the core alpha/beta-hydrolase fold with bacterial PETases, but contains a unique lid common in feruloyl esterases, which is involved in substrate binding. Thus, our study widens the currently known diversity of PET-hydrolyzing enzymes, by demonstrating PET depolymerization by a plant cell wall-degrading esterase.
Magneto-assisted enzymatic DNA walkers for simultaneous electrochemical detection of amyloid-beta oligomers and Tau
Authors: Cheng Tao , Yuan Hongxiu , Dong Yixi , Xu Shuo , Wang Gang , Zhao Miaoqing , Jiao Jianwei , Jiao Jin 
Published: September 2023

An electrochemical aptasensor for AβO and Tau simultaneously detection and used successfully identifies Alzheimer’s patients among real samples.
SURGICAL TREATMENT OF GLOSSOPHARYNGEAL NEURALGIA: A 10 YEAR EXPERIENCE
Authors: Rychlicki F. , Morabito L. , Dobran M. , Mora A. , Pauri F. , Ricciuti R.A. , Trignani R. , Veronesi V. 
Published: September 2023

First described by Weisenburg in 1910, glossopharyngeal neuralgia is paroxysmal, lighting, excruciating pain referred to the posterior lingual region, tonsillar pillar, throat, external auditory canal and pinna. It is much less frequently encountered than trigeminal neuralgia with a reported relative frequency of the order of 1%. It is often secondary to neoplastic processes of the oropharyngeal region but can also be caused by mechanical compression of abnormal vessels on the nerve root. Less frequently it is of essential or idiophatic origin. Between 1990 and 2000, operations were performed at our Institute on 3 patients, all women ranging in age from 61 to 80 years, with glossopharyngeal neuralgia. All the patients had been taking caramazepine with only temporary initial improvement and in 2 cases parenteral feeding had been necessary before admission. The first 2 patients were submitted to percutaneous thermocoagulation rhizotomy of the inferior petrous ganglion of Andersch at the jugular foramen, the third to open procedure consisting in vascular decompression of the ninth nerve in posterior fossa. The follow‐up ranges from 2 to 10 years. The results were excellent or very good in all cases at the time of evaluation.The authors emphasize the role of surgical therapy in glossopharyngeal neuralgia when medical therapy fails.
Improved hybrid discretisation of volume integral equation with the characteristic basis function method for analysing scattering from complex dielectric objects
Authors: Huang Fei , Sun Yufa , Li Ming , Wang Dalei 
Published: September 2023

AbstractThe improved hybrid discretisation of volume integral equation (VIE) combined with the characteristic basis function method is proposed to analyse the scattering from complex dielectric objects in this study. To mitigate the excessive number of discrete elements which arise from the conformal discretisation on the complex dielectric objects, the hybrid discretisation is developed. For the conventional hybrid discretisation, the conformal Schaubert–Wilton–Glisson (SWG) basis functions are used to discretise the homogeneous regions, meanwhile, the non‐conformal half‐SWG basis functions are employed to discretise the boundary regions which separate different materials or multiscale structures. The hybrid discretisation takes advantage of the merits of both conformal and non‐conformal basis functions and improves the computational efficiency for solving the VIE. In our study, a kind of edge basis function defined within boundary tetrahedral elements substitutes for the SWG basis functions to model the boundary regions, leading to the further reduction on the number of basis functions. Moreover, the characteristic basis functions extracted from the low‐level basis functions are employed to construct the reduced matrix of which the size is considerably smaller than that of the system matrix derived from the VIE. Several numerical results are presented to demonstrate the accuracy and efficiency of the proposed method.
3D coupled tearing-thermal evolution in solar current sheets
Authors: Sen Samrat , Jenkins Jack , Keppens Rony 
Published: September 2023

Context.The tearing instability plays a major role in the disruption of current sheets, whereas thermal modes can be responsible for condensation phenomena (forming prominences and coronal rain) in the solar atmosphere. However, how current sheets made unstable by combined tearing and thermal instability evolve within the solar atmosphere has received limited attention to date.Aims.We numerically explore a combined tearing and thermal instability that causes the break up of an idealized current sheet in the solar atmosphere. The thermal component leads to the formation of localized, cool condensations within an otherwise 3D reconnecting magnetic topology.Methods.We constructed a 3D resistive magnetohydrodynamic simulation of a force-free current sheet under solar atmospheric conditions that incorporates the non-adiabatic influence of background heating, optically thin radiative energy loss, and magnetic-field-aligned thermal conduction with the open source codeMPI-AMRVAC. Multiple levels of adaptive mesh refinement reveal the self-consistent development of finer-scale condensation structures within the evolving system.Results.The instability in the current sheet is triggered by magnetic field perturbations concentrated around the current sheet plane, and subsequent tearing modes develop. This in turn drives thermal runaway associated with the thermal instability of the system. We find subsequent, localized cool plasma condensations that form under the prevailing low plasma-βconditions, and demonstrate that the density and temperature of these condensed structures are similar to more quiescent coronal condensations. Synthetic counterparts at extreme ultraviolet (EUV) and optical wavelengths show the formation of plasmoids (in EUV) and coronal condensations similar to prominences and coronal rain blobs in the vicinity of the reconnecting sheet.Conclusions.Our simulations imply that 3D reconnection in solar current sheets may well present an almost unavoidable multi-thermal aspect that forms during their coupled tearing-thermal evolution.
Vers un consentement plus éclairé
Authors: Gozlan Diane , Mathieu Marion , de Montgolfier Sandrine , Morillon Lucie , Demaret Béatrice , Pierrart Carole , Fourmy Chantal Aubert , Lamarche Dominique , Koulikoff Frédérique , Nowak Frédérique , Zucker Jean-Michel , Malen Jean-Pierre , Avram Flore , Panchal Maï , Lanta Marie , Prouvost Marie-France , Maizeroi Myriam , Tronel Vincent , Mathieu Flavie 
Published: September 2023

Trop souvent, les notices d’information proposées dans le cadre de recherches cliniques se réduisent à des documents réglementaires difficilement compréhensibles. Pourtant, les personnes concernées doivent avoir accès à une information transparente et loyale. Ces considérations ont motivé la création d’un groupe de travail pluridisciplinaire, piloté par le Collège des relecteurs de l’Inserm, associant les acteurs impliqués dans l’élaboration, l’évaluation et l’utilisation de ces notices d’information. Un ensemble de textes, pictogrammes et illustrations, adaptés aux personnes concernées, validés et facilement utilisables via une application a été créé. Une phase pilote, dans le cadre du plan France médecine génomique 2025, a permis de générer des notices simplifiées pour les examens génétiques. Dans cet article, nous présentons le travail réalisé par le groupe de travail « Notices d’information » afin de répondre à la demande sociétale d’être acteur de son parcours de soin et de contribuer à une recherche plus éthique et responsable.
Je mène donc tu suis
Authors: Emery Gregory 
Published: September 2023

Lors du développement et de la cicatrisation, les cellules se déplacent souvent par un processus de « migration cellulaire collective ». Un procédé identique est employé par les cellules de certaines tumeurs cancéreuses lors de la formation de métastases. Un remarquable modèle d’étude de la migration cellulaire collective est celui de l’étude du groupe (cluster) de cellules de bordure de la drosophile, qui permet d’observer et de manipuler une migration collective dans son environnement naturel. Cette revue décrit la machinerie moléculaire qui permet à ce groupe de cellules de migrer directionnellement, en se concentrant sur les mécanismes permettant aux cellules de détecter et réagir aux chimioattractants et d’organiser le groupe en cellulesleaderset suiveuses.
Das virtuelle ILD-Board – Erfahrungen aus einem Pilotprojekt
Authors: Hauber Roman , Kreuter Michael , Dinkel Julien , Schön Franziska , Hellmann Andreas , Behr Jürgen 
Published: September 2023

ZusammenfassungInterstitielle Lungenerkrankungen sind mit hoher Morbidität und Mortalität assoziiert. Um eine bestmögliche Behandlung zu ermöglichen, ist eine zügige Diagnostik in einem qualifizierten Zentrum erforderlich. Entfernung und Organisation führen jedoch zu relevanten Verzögerungen. Wir haben ein digitales System pilotiert, das solche Verzögerungen zur Unterstützung niedergelassener Pneumologen minimieren soll. Das „virtuelle ILD-Board“ führt zu einer deutlich schnelleren Diagnostik für die Patienten. Das Tool ist daher eine mögliche Unterstützung für den niedergelassenen Pneumologen. Die Standardisierung erhöht die Patientensicherheit durch Sicherstellung der interdisziplinären Begutachtung und leistet somit einen relevanten Beitrag zum Management und zur leitliniengerechten Versorgung der interstitiellen Lungenerkrankungen.
Die Mobile psychiatrische Rehabilitation als zentraler Baustein in
der Versorgung schwer psychisch kranker Menschen
Authors: Konrad Michael , Gühne Uta 
Published: September 2023

HintergrundDer Zugang zu rehabilitativen Komplexleistungen in den stationären
Einrichtungen der medizinischen Rehabilitation ist nahezu ausschließlich
psychosomatisch und leicht psychisch erkrankten sowie
abhängigkeitserkrankten Personen vorbehalten 1. Schwer psychisch erkrankte Menschen werden auf die
medizinisch-berufliche Komplexleistung der Rehabilitationseinrichtung für
psychisch Kranke (RPK) verwiesen, für die sie jedoch meist nicht die
Aufnahmevoraussetzungen erfüllen. Selbst bei der ambulanten RPK-Leistung
wird die Teilnahme an täglich mindestens vier bis acht Stunden Therapiezeit
an fünf bis sechs Tagen in der Woche vorausgesetzt. Gemeindepsychiatrische
Leistungen erhalten sie in der Regel in unterstützten Wohnformen der
Eingliederungshilfe, in denen im Jahr 2019 mehr als 200.000 Menschen mit seelischer
Behinderung erfasst wurden 2. Ambulante
Komplexleistungen der medizinischen Rehabilitation im Anschluss an die
stationäre oder stationsäquivalente (StäB) Akutbehandlung
sind sozialrechtlich bisher nicht erschlossen.
Macrophage Ferroptosis Promotes MMP2/9 Overexpression Induced by Hemin in Hemorrhagic Plaque
Authors: Li Bicheng , Lu Minqiao , Wang Hui , Sheng Siqi , Guo Shuyuan , Li Jia , Tian Ye 
Published: September 2023

Background Intra-plaque hemorrhage (IPH) leads to rapid plaque progression and instability through upregulation of matrix metalloproteinases (MMPs) and collagen degradation. Hemoglobin-derived hemin during IPH promotes plaque instability. We investigated whether hemin affects MMP overexpression in macrophages and explored the underlying mechanisms.
Material and Methods In vivo, hemorrhagic plaque models were established in rabbits and ApoE−/− mice. Ferrostatin-1 was used to inhibit ferroptosis. Plaque size, collagen, and MMP2/9 levels were evaluated using immunohistochemistry, H&E, Sirius Red, and Masson staining. In vitro, mouse peritoneal macrophages were extracted. Western blot and ELISA were used to measure MMP2/9 levels. Bioinformatics analysis investigated the association between MMPs and ferroptosis pathway genes. Macrophage ferroptosis was assessed by evaluating cell viability, lipid reactive oxygen species, mitochondrial ultrastructure, iron content, and COX2 levels after pretreatment with cell death inhibitors. Hemin's impact on ferroptosis and MMP expression was studied using Ferrostatin-1 and SB202190.
Results In the rabbit hemorrhagic plaques, hemin deposition and overexpression of MMP2/9 were observed, particularly in macrophage-enriched regions. In vitro, hemin induced ferroptosis and MMP2/9 expression in macrophages. Ferrostatin-1 and SB202190 inhibited hemin-induced MMP2/9 overexpression. Ferrostatin-1 inhibited p38 phosphorylation in macrophages. Ferostatin-1 inhibits macrophage ferroptosis, reduces MMP2/9 levels in plaques, and stabilizes the hemorrhagic plaques.
Conclusion Our results suggested that hemin-induced macrophage ferroptosis promotes p38 pathway activation and MMP2/9 overexpression, which may play a crucial role in increasing hemorrhagic plaque vulnerability. These findings provide insights into the pathogenesis of hemorrhagic plaques and suggest that targeting macrophage ferroptosis may be a promising strategy for stabilizing vulnerable plaque.
Nocturnal Polysomnography without Technical Supervision in the Diagnosis of Respiratory Sleep Disorders, Diagnostic Performance of Home and Sleep Laboratory Studies
Authors: Angellotti María Florencia , Grandval Sofía , Palma Ileana , Giovini Vanina , Jaritos Verónica , Diaz-Lapasini Gastón , Carnevale Denise , Nogueira Juan Facundo 
Published: September 2023

Abstract
Introduction Unattended Polysomnography (type 2 PSG) is a procedure for the diagnosis of sleep-disordered breathing (SDB). Published evidence on its performance and efficacy is limited. Available studies reveal a high rate of lost records that could limit its application.
Objective To assess the efficacy of type 2 PSG and the rate of studies that must be repeated due to critical loss of signals.
Methods prospective, descriptive study. Adult patients with suspected SDB were included. Unattended PSG was performed using portable equipment. 75 patients were connected at home and another 75 in the laboratory, without subsequent monitoring. Records were evaluated to determine the percentage of the night with adequate quality for each of the signals, considered as an evaluable signal for = 70% of the total recording time (TRT). The need to repeat the studies was also estimated. Results: 150 patients were recruited; 44% women; age 57.3 ± 15.4 years; BMI 29.4 ± 6.5. EEG and EOG signals were adequate in 149 records. Flow signal by pressure cannula was adequate in 146 and by thermistor in 67.8%. In only one study the signal of both effort bands were inadequate. Oximetry was lost in 4 cases. Ten tracings (6%) met the criteria for repetition; 8 hospital and 2 home.
Conclusions Acceptable records were obtained in most unattended PSG studies, both at home and in the sleep laboratory. The rate of repetition of studies due to loss of signal was 6%, with failure in SaO2 or in flow signals being the main cause of the indication.
Sleep Medicine Knowledge Among Graduating Medical Students in Lebanon During an Economic and Political Crisis: A Preliminary Survey
Authors: Aoun Raissa , Zibara Victor , Costanian Christy , Attarian Hrayr P. , Bahous Sola Aoun 
Published: September 2023

Abstract
Objectives Sleep disorders are prevalent and underrecognized during both economic and political crises. They are a major reason for poor overall health and decreased quality of life. Sleep medicine education is limited at most medical schools, resulting in limited awareness of this important aspect of healthcare. The aim of the study is to assess sleep medicine knowledge of graduating medical students in Lebanon and to assess their readiness to tackle sleep health issues in a country during an unprecedented crisis.
Methods Final-year medical students at 7 medical schools in Lebanon were invited to fill a survey between January 2020 and March 2021. The Assessment of Sleep Knowledge in Medical Education survey was used to assess their knowledge in sleep medicine. The curriculum organizers at the medical schools were also surveyed. Student's t-test was used for analysis.
Results 158 and 58 students completed the survey during 2020 and 2021, with a mean overall score on sleep knowledge of was 17.5 and 15.9 /30, respectively. There was no difference in mean knowledge scores by gender, age, American versus European medical school systems, and between medical schools that included sleep medicine in their curriculum versus those that did not.
Conclusions Presence of sleep medicine education in the curriculum was associated with higher scores on ASKME among graduating Lebanese medical students. Given the low response rate, however, this descriptive pilot data could be used as a launching pad for a larger study, with a more representative sample, for generalizable results.
A vital sign signal noise suppression method for wearable piezoelectric devices
Authors: Xin Yi , Liu Hongyan , Hou Tianyuan , Song Xuefeng , Tong Junye , Cui Meng , Li Meina , Zhai Jingjie 
Published: September 2023

This paper tackles the problem of noise suppression during vital sign signal monitoring. Physiological signal monitoring is a significant and promising medical monitoring method, and wearable medical monitoring devices based on piezoelectric polymer sensors are a trending way for their advantages of being flexible in the shape, portable to use, and comfortable to wear. However, this raises the question that the measured signal contains much more noise components. To avoid the following shortcoming of low signal to noise ratio (SNR), a noise suppression method based on improved wavelet threshold and empirical mode decomposition combined with singular value decomposition (SVD) screening the intrinsic mode function (IMF) components is proposed. A wavelet transform is first used under the combination of hard and soft thresholds to focus the target range in the low-frequency region where the energy of the physiological signal is concentrated. Then, a complete ensemble empirical mode decomposition is used to decompose the signal effectively, which can resist the influence of random noises. Meanwhile, a SVD decomposition procedure was used to filter out the lower correlated IMF components to retain the validity of the original signal. We verified the effectiveness of the proposed method through simulated and measured experiments as well as the advantages and disadvantages of the algorithm compared with other physiological signal denoising algorithms through SNR filtering results, power spectrum distribution, and other perspectives. The results proved that the proposed method could effectively remove more detailed noise and improve the SNR of the signal efficiently, which is more conducive to the demand for auxiliary medical diagnosis in the future.
Spectral analysis of DNA superhelical dynamics from molecular minicircle simulations
Authors: Curuksu Jeremy D. 
Published: September 2023

Torsional and bending deformations of DNA molecules often occur in vivo and are important for biological functions. DNA “under stress” is a conformational state, which is by far the most frequent state during DNA–protein and gene regulation. In DNA minicircles of length &lt;100 base pairs (bp), the combined effect of torsional and bending stresses can cause local unusual conformations, with certain base pair steps often absorbing most of the stress, leaving other steps close to their relaxed conformation. To better understand the superhelical dynamics of DNA under stress, molecular simulations of 94 bp minicircles with different torsional linking numbers were interpreted using Fourier analyses and principal component analyses. Sharp localized bends of nearly 90° in the helical axis were observed, which in turn decreased fluctuations of the rotational register and helped redistribute the torsional stress into writhe, i.e., superhelical turn up to 360°. In these kinked minicircles, only two-thirds of the DNA molecule bends and writhes and the remaining segment stays close to straight and preserves a conformational flexibility typical of canonical B-DNA (bending of 39° ± 17° distributed parsimoniously across 36 bp), which was confirmed and visualized by principal component analysis. These results confirm that stressed DNA molecules are highly heterogeneous along their sequence, with segments designed to locally store and release stress so that nearby segments can stay relaxed.