bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spatiotemporal evolution and influencing factors of China’s economic development performance under carbon emission constraints
Authors: Xie Zhixiang , Zhao Rongqin , Xiao Liangang , Ding Minglei 
Published: August 2023

Abstract
Background
China’s high-quality economic development depends on achieving sustainable economic development, reaching peak carbon emissions, achieving carbon neutrality, and intensifying the development of an industrial and energy structure that saves resources and protects the environment. This study used the data envelopment analysis (DEA) model and the Malmquist productivity index to measure the economic development performance of mainland China under carbon emission constraints. Then, it described the spatiotemporal evolution of economic development performance and analyzed its influencing factors using the Tobit model.

Results
The results revealed that there were obvious differences in the trends of the static and dynamic performance of economic development. On the one hand, the static performance of economic development exhibited an upward trend from 2008 to 2020. Its distribution characteristics were dominant in the higher and high-level areas. On the other hand, the dynamic performance had a downward trend from 2008 to 2016 and then an upward trend from 2016 to 2020. In most provinces, the dynamic performance was no longer constrained by technological progress but rather by scale efficiency. It was found that the main factors influencing economic development performance were urbanization level, energy efficiency, vegetation coverage, and foreign investment, while other factors had no significant influence.

Conclusions
This study suggests that China should improve its economic development performance by increasing the use of clean energy, promoting human-centered urbanization, increasing carbon absorption capacity, and absorbing more foreign capital in the future.
Living with a rare disease - experiences and needs in pediatric patients and their parents
Authors: Witt Stefanie , Schuett Katharina , Wiegand-Grefe Silke , Boettcher Johannes , Quitmann Julia 
Published: August 2023

AbstractBackgroundA rare disease (RD) diagnosis and therapy can affect the family’s quality of life and mental health. A lack of information and missing care options lead to helplessness and psychological stress within families. This work aims to identify patients’ and parents’ experiences in daily life and with the health care system as well as their needs and current pathways to psychosocial care to develop implementation strategies adapted to the families’ needs.MethodsThe present analysis is part of the national multicenter study “Children Affected by Rare Disease and Their Families-Network (CARE-FAM-NET).“ We conducted semi-structured telephone interviews with children, adolescents, and young adults with RD (aged 12 to 21 years) and parents of children with RD (aged 0 to 17 years). We analyzed the transcribed and anonymized interviews using the method of focused interview analyses to identify previous experiences with medical and psychosocial care and possible needs for improvement and support.ResultsSeventy-four parents of children with RD and 15 children, adolescents, and young adults with RD participated. Five main themes emerged.Daily life with an RD: RD affects the everyday and social life of the respondents, negatively impacting mental well-being.Experiences with the health care system: The long diagnostic path is stressful for families. Professionals’ lack of information/education leads to inadequate care for those affected.Psychosocial support: Families do not know about psychosocial care services. In some cases, the families take advantage of psychosocial support services (such as support groups or advocacy groups), which are predominantly very helpful.Difficulties and barriers: Time, socio-legal and organizational problems burden families and lead to advantages in using psychosocial services.Improvements for patient-oriented support: Those affected wished for timely, preventive support (especially in administrative and socio-legal matters) and education regarding psychosocial care services.ConclusionRD represent a great challenge for all family members – patients, parents, and siblings. The patients’ and parents’ previous experiences in daily life, medical and psychosocial care show a need for target-group specific support, including training of health care professionals and low-threshold access care services and practical help for all family members.
The Hippo signaling pathway contributes to the 2,5-Hexadion-induced apoptosis of ovarian granulosa cells
Authors: Sun Yi , Chen Huiting , Chen Sichuan , Xu Xueming , Zhang Wenchang , Li Yuchen 
Published: August 2023

AbstractAlthough n-hexane can induce ovarian damage by inducing ovarian granulosa cell (GC) apoptosis, the mechanism underlying this induction of apoptosis has not been fully elucidated. In this study, rat ovarian GCs were exposed to different concentrations of 2,5-hexanedione (2,5-HD) (the main metabolite of n-hexane) in vitro to observe apoptosis, and the mechanism was further explored via mRNA microarray analysis. Hoechst 33258 staining and flow cytometry suggested that the apoptosis rate of ovarian GC apoptosis was significantly increased in the 2,5-HD-treated group. Subsequently, microarray analysis revealed that a total of 5677 mRNAs were differentially expressed, and further GO and KEGG analyses revealed that the differentially expressed genes were significantly enriched in many signaling pathways, including the Hippo pathway. A total of 7 differentially expressed genes that function upstream of the Hippo signaling pathway (Nf2, Wwc1, Ajuba, Llgl1, Dlg3, Rassf6 and Rassf1) were selected to confirm the microarray results by qRT-PCR, and the expression of these genes did change. Subsequently, the expression of key effector genes (Yap1, Mst1 and Lats1) and target genes (Ctgf and Puma) of the Hippo signaling was measured, and the results suggested that the mRNA and protein levels of Yap1, Mst1, Lats1, and Ctgf were significantly decreased while those of Puma were significantly increased after 2,5-HD treatment. Further CO-IP analysis suggested that the interaction between YAP1 and TEAD was significantly reduced after 2,5-HD treatment, while the interaction between YAP1 and P73 was not affected. In summary, during the 2,5-HD-induced apoptosis of ovarian GCs, the Hippo signaling pathway is inhibited, and downregulation of the pro-proliferation gene Ctgf and upregulated of the pro-apoptosis gene Puma are important. Decreased Ctgf expression was associated with decreased binding of YAP1 to TEAD. However, increased PUMA expression was not associated with YAP1 binding to P73.
Associations between basic motor competencies and physical fitness in Spanish pre-schoolers: a cross-sectional study
Authors: Legarra-Gorgoñon Gaizka , García-Alonso Yesenia , Ramírez-Vélez Robinson , Erice-Echegaray Blanca , Izquierdo Mikel , Alonso-Martínez Alicia M. 
Published: August 2023

Abstract
Background
Basic motor competencies (BMC) play a vital role in child development and are a primary focus of physical education. However, there is a lack of research on BMC in preschool-aged children, making this study particularly significant. The present study aims to examine the relationship between BMC and physical fitness components in Spanish preschool children.

Methods
This cross-sectional study was conducted on 101 children (n = 52 boys, average age of 4.80 years) living in Pamplona, North Spain. Components of physical fitness (handgrip strength, standing long jump, speed-agility, and cardiorespiratory fitness) were assessed using the PREFIT Battery. Overall physical fitness was computed from the four selected fitness components separately for boys and girls. Higher z-scores values in physical fitness indicate better fitness performance. To assess BMC, the MOBAK KG test battery was applied (subscales of object control and self-movement). Sex, age, and body mass index were used as main confounders.

Results
After adjustment for confounding factors, the BMC was positively associated with single (z-scores) components and overall physical fitness sum of z-scores (R2 from 0.178 to 0.469, all P-values < 0.05). Additional percentile scores weakened the associations, but they still remained significant (R2 from 0.146 to 0.337, all P-values < 0.05). Compared with participants in the lowest tertile, those in the highest tertile of the MOBAK KG sum score, and in both object movement and self-movement test subscales had significantly higher scores in single fitness component (z-scores or percentile) and overall physical fitness sum of z-scores (all P for trend < 0.001).

Conclusions
Our results revealed that higher BMC is associated with better physical fitness in Spanish preschool children. The findings emphasize the crucial role that basic motor competence plays in promoting physical activity in preschool children.
Wide-scale identification of novel/eliminated genes responsible for evolutionary transformations
Authors: Lyubetsky Vassily A. , Rubanov Lev I. , Tereshina Maria B. , Ivanova Anastasiya S. , Araslanova Karina R. , Uroshlev Leonid A. , Goremykina Galina I. , Yang Jian-Rong , Kanovei Vladimir G. , Zverkov Oleg A. , Shitikov Alexander D. , Korotkova Daria D. , Zaraisky Andrey G. 
Published: August 2023

Abstract
Background
It is generally accepted that most evolutionary transformations at the phenotype level are associated either with rearrangements of genomic regulatory elements, which control the activity of gene networks, or with changes in the amino acid contents of proteins. Recently, evidence has accumulated that significant evolutionary transformations could also be associated with the loss/emergence of whole genes. The targeted identification of such genes is a challenging problem for both bioinformatics and evo-devo research.

Results
To solve this problem we propose the WINEGRET method, named after the first letters of the title. Its main idea is to search for genes that satisfy two requirements: first, the desired genes were lost/emerged at the same evolutionary stage at which the phenotypic trait of interest was lost/emerged, and second, the expression of these genes changes significantly during the development of the trait of interest in the model organism. To verify the first requirement, we do not use existing databases of orthologs, but rely purely on gene homology and local synteny by using some novel quickly computable conditions. Genes satisfying the second requirement are found by deep RNA sequencing. As a proof of principle, we used our method to find genes absent in extant amniotes (reptiles, birds, mammals) but present in anamniotes (fish and amphibians), in which these genes are involved in the regeneration of large body appendages. As a result, 57 genes were identified. For three of them, c-c motif chemokine 4, eotaxin-like, and a previously unknown gene called here sod4, essential roles for tail regeneration were demonstrated. Noteworthy, we established that the latter gene belongs to a novel family of Cu/Zn-superoxide dismutases lost by amniotes, SOD4.

Conclusions
We present a method for targeted identification of genes whose loss/emergence in evolution could be associated with the loss/emergence of a phenotypic trait of interest. In a proof-of-principle study, we identified genes absent in amniotes that participate in body appendage regeneration in anamniotes. Our method provides a wide range of opportunities for studying the relationship between the loss/emergence of phenotypic traits and the loss/emergence of specific genes in evolution.
Prospective, randomized, double-blind, double-dummy, active-controlled, phase 3 clinical trial comparing the safety and efficacy of intranasal dexmedetomidine to oral midazolam as premedication for propofol sedation in pediatric patients undergoing magnetic resonance imaging: the MIDEX MRI trial
Authors: Wabelo Olivia Nzungu , Schmartz Denis , Giancursio Mario , De Pooter Françoise , Caruso Giulia , Fils Jean-François , Van der Linden Philippe 
Published: August 2023

Abstract
Background
Children under 6 years who need magnetic resonance imaging usually require sedation to obtain best quality images, but the optimal sedation protocol remains to be determined. In 2018, we showed a 22% interruption in image acquisition during magnetic resonance imaging when performing a propofol-based sedation using a bolus approach. As non-pharmacological premedication is often insufficient to reduce the anxiety of children related to parental separation, pharmacological premedication may be useful to facilitate the induction of anesthesia. In our institution, effective premedication is obtained oral intake of midazolam, though its administration relies on patients’ compliance and could also lead to paradoxical reaction. Dexmedetomidine has a safe profile in the pediatric population and can therefore represent an interesting alternative. The primary objective of this trial is to demonstrate the superiority of intranasal dexmedetomidine compared to oral midazolam as premedication in reducing the occurrence of any event requiring temporary or definitive interruption of the examination to allow anesthesiologist intervention in children undergoing magnetic resonance imaging under propofol sedation.

Methods
In this single-center, prospective, randomized, double-blind, double-dummy, active comparator-controlled, superiority trial, we planned to include 250 patients, aged 6 months to 6 years, undergoing a scheduled magnetic resonance imaging requiring the presence of an anesthesiologist. After informed consent, the patients will be randomized to receive either oral midazolam or intranasal dexmedetomidine as premedication. The data will be analyzed in intention to treat, using Kolmogorov–Smirnov Z, chi-square, Wilcoxon, and Mann–Whitney U tests. A P-value < 0.05 will be considered statistically significant.

Discussion
The MIDEX MRI study will assess the efficacy of intranasal dexmedetomidine compared to oral midazolam to improve the quality of a propofol-based sedation prior to magnetic resonance imaging, without negative repercussion on the postoperative period.

Trial registration
ClinicalTrial.gov NCT05192629. Registered on 14 January 2022. Protocol version 2.1
New results of partially total fuzzy graph
Authors: Agama Fekadu Tesgera , Repalle V. N. SrinivasaRao , Rathour Laxmi 
Published: August 2023

Abstract
Objective
The study of total fuzzy graphs in all cases is crucial for the development of both theories and applications of the graph theory. Without theory the application will not be developed. Hence this manuscript attempted to theorize the conception of partially total fuzzy graphs.

Results
The article introduced the partially total fuzzy graph by keeping all the conditions of fuzziness as it is. From these definitions, it is endeavored to get the partial total fuzzy graph of a given fuzzy graph which is supported by illustrations. Also, some propositions and theorems related to this concept were developed and proved.
A nomogram for predicting the risk of new vertebral compression fracture after percutaneous kyphoplasty
Authors: Zhang Aiqi , Lin Yichen , Kong Mingxiang , Chen Jiahao , Gao Wei , Fan Jiajun , Wang Junjie , Chen Zhe 
Published: August 2023

Abstract
Background
New vertebral compression fractures (NVCFs) are common adverse events in percutaneous kyphoplasty (PKP). The present study aimed to investigate the risk factors for NVCFs in patients after PKP and to construct a nomogram for the prediction of the risk of re-fracture.

Methods
We retrospectively analyzed the medical records of patients after PKP surgery between January 2017 and December 2020. Patients were divided into an NVCF group (n = 225) and a control group (n = 94) based on the presence or absence of NVCFs, respectively, at follow-up within 2 years after surgery. Lasso regression was used to screen for risk factors for re-fracture. Based on the results, a Lasso-logistic regression model was developed, and its prediction performance was evaluated using receiver operating characteristic curves, calibration, and decision curve analysis. The model was visualized, and a nomogram was constructed.

Results
A total of eight potential predictors were obtained from Lasso screening. Advanced age, low body mass index, low bone mineral density, lack of anti-osteoporosis treatment, low preoperative vertebral body height, vertebral body height recovery ≥ 2, cement leakage, and shape D (lack of simultaneous contact of bone cement with the upper and lower plates) were included in the logistic regression model.

Conclusions
A nomogram for predicting postoperative NVCF in PKP was developed and validated. This model can be used for rational assessment of the magnitude of the risk of developing NVCFs after PKP, and can help orthopedic surgeons make clinical decisions aimed at reducing the occurrence of NVCFs.
Impact of sustainability on financial distress in the air transport industry: the moderating effect of Asia–Pacific
Authors: Shi Yin , Li Xiaoni , Asal Maher 
Published: August 2023

AbstractThe tremendous impact of the coronavirus pandemic on the global aviation industry has led to many cases of airline financial distress and bankruptcy. The Asia–Pacific region (APAC) contains more than half of the world’s population, and its airlines had the highest profit margin of any region. In this study, we investigate whether corporate sustainability practice can reduce the financial distress risk of air carriers, and, if so, what would the effect be in APAC? We first examine the relationship between environmental, social, and governance disclosure and the likelihood of financial distress of airlines as measured by the Altman Z″-score. Second, we analyze the moderating role of being an APAC airline in this relationship. The findings support the claim that implementing environmental actions may increase financial distress risk, and by improving social and governance activities, airlines can mitigate the risk of financial distress. The negative influence of the environmental pillar and the positive influence of the social pillar can be smaller for APAC airlines. Our study provides empirical evidence of the influence of environmental, social, and governance (ESG) on the likelihood of financial distress in the airline industry. Moreover, we analyze the moderating role of being an APAC airline in the relationship between sustainability and financial distress. This study has significant implications for executives, managers, and policymakers in the aviation industry on ESG strategy decisions and the general issue of sustainability.
Going beyond the ‘typical’ student? Voicing diversity of experience through biographical encounters with migrant students in Portugal
Authors: Nada Cosmin , Ploner Josef , Van Mol Christof , Araújo Helena C. 
Published: August 2023

AbstractResearch on international student migration has been burgeoning, leading to a more nuanced understanding of international students whose experiences were, for many years, conceptualised in a rather limited way. In this paper, we aim to advance understanding of the diversity and complexity of student migrants’ experiences, by proposing a new interpretive framework, developed through narrative enquiry. Based on an in-depth narrative analysis of 41 “biographical encounters” with student migrants in Portugal, we illustrate the potential of biographical approaches in highlighting students’ subjectivities, and the complex interplay of diverse factors that shape migration processes. A migration “profile” was assigned to each narrative, capable of representing its leitmotif. This biographical approach to student migration provides a more nuanced understanding of how student migration emerges in time, thus offering a methodological approach that does justice to the diversity of student migration trajectories and may enhance the empirical examination of their experiences.
Adolescent breakfast skipping is associated with poorer academic performance: a school-based study from Hidhabu Abote District, Ethiopia
Authors: Feye Dereje , Gobena Tesfaye , Brewis Alexandra , Roba Kedir Teji 
Published: August 2023

Abstract
Background
Breakfast is regarded as “the most important meal of the day,” suggested to positively affect learning in children and adolescent in terms of cognitive and school performance. Yet, studies in LMIC settings are few and show very inconsistent results.

Objective
To assess the prevalence and correlates of breakfast skipping and its association with school performance among randomly selected in-school adolescents in Hidhabu Abote Wereda, North Shewa Zone, Central Ethiopia.

Methods
A cross-sectional study was conducted from November to December 2020. A total of 422 participants were selected randomly from high schools of Hidhabu Abote Wereda. Data were entered in to Epiata version 3.1 and exported to SPSS version 24 for analysis. Bivariate and multivariate binary logistic regression analysis identified factors that were significantly associated with the breakfast skipping. Odds ratio along with 95% Confidence interval was estimated to measure the strength of the association and level of statistical significance declared at p-value less than 0.05.

Results
The magnitude of breakfast skipping was 41.3%, (95% CI (36.6–46.0)]. There was statistically significant association between breakfast skipping and overall academic performance [AOR: 5.18, 95% CI (1.54–7.46)], mathematics performance (3.88, 95% CI (1.34–11.22)], and English language performance scores [2.92, 95% CI (1.38–7.58)]. Being female [AOR = 1.857, 95% CI (1.05–3.27)], household food insecurity [AOR: 2.478, 95% CI (1.36–4.51)], and less maternal education [AOR 1.89, 95% CL (3.38–7.77)] were independently associated with breakfast skipping. The primary reasons given for breakfast skipping were lack of time, lack of appetite in morning, and concerns around weight gain.

Conclusion
Nearly half of in-school adolescents were skipped breakfast meals, and reportedly in most cases for reasons unrelated to lack of food access. Students who skipped breakfast had lower levels of school performance.
Synergies and scaling of use case combinations in the field of asset logging and labeling
Authors: Wasmeier Louisa , Dossow Patrick , Hinterstocker Michael 
Published: August 2023

AbstractThe digitalization of the energy sector enables a broad range of new digital use cases and business models. For instance, blockchain-technology can be used for the verification of tamper-resistant storage of asset data (asset logging) or manipulation-resistant guarantees of origin for electricity (labeling). Yet, it is associated with high implementation and operating effort. But many of these use cases require similar players, interfaces, data sets and data processing, so that synergies can result from a joint implementation. We thus evaluate these synergies in implementation and operating effort for use cases in the field of asset logging and labeling using a bottom-up evaluation of the components based on a methodology of Dossow (Energies 16:2424, 2022). Additionally, we extend this methodology to analyze the scalability of the use cases by assessing the relative effort reduction for an increasing number of players involved. The analysis already shows substantial synergies for combinations of two use cases. Yet, especially for combinations of three or more use cases a high effort reduction potential is derived. The highest synergies are obtained among the asset logging use cases, while a combination of asset logging and labeling use cases shows lower synergies in comparison. The analysis of the scaling of the use cases demonstrates that for labeling use cases the main effort driver is the number of consumers, while for asset logging use cases the number of asset operators shows to be more relevant. Thus, scaling effects outweigh the effort reduction potential of use case combinations especially for combinations of asset logging and labeling cases.