bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vacuum sealing drainage system combined with an antibacterial jackfruit aerogel wound dressing and 3D printed fixation device for infections of skin soft tissue injuries
Authors: Hu Xin , Li Huijian , Guo Wenting , Xiang Huiqin , Hao Liang , Ai Fanrong , Sahu Souradeep , Li Chen 
Published: December 2022

AbstractInjuries and infections of skin and soft tissue are commonly encountered in primary health care and are challenging to manage. Vacuum sealing drainage (VSD) is generally used in clinical treatment, but current commercial methods of VSD have some disadvantages, such as easy blockage, nonantibacterial effects, and inconvenient curved surfaces. Herein, we report a functional zinc oxide/jackfruit aerogel (ZnO/JFA) composite material that is ultralight, superabsorbent and antibacterial as a new antibacterial VSD wound dressing. The JFA is carbonized from fresh jackfruit, and the JFA exhibits superhydrophilicity and superabsorbability. The water absorption rate of JFA was up to 1209.39%, and the SBF absorption rate was up to 1384.22%. The water absorption rate of ZnO/JFA was up to 494.47%, and the SBF absorption rate was up to 473.71%. The JFA and ZnO/JFA possess a pipeline structure, which is beneficial for absorbing wound exudates. In addition, surface modification of nanosized ZnO and its effects on antibacterial properties and biocompatibility were performed. When the concentration of ZnO/JFA was 3.125 mg/mL, the survival rate of human fibroblast cells was close to 80%, while the antibacterial rates against Staphylococcus aureus, Pseudomonas aeruginosa and Escherichia coli were up to 99.06%, 75.28% and 93.58%, respectively. Moreover, a 3D printed assisted device was introduced to make the ZnO/JFA wound dressing more attached to the bottom of the wound on a curved surface. An integrated device was formed under the printing mold, and then animal experiments were conducted in vivo. The results showed that a healing rate of almost 100% for infected skin wounds was obtained with this novel VSD device after 14 days, compared to only 79.65% without the VSD device. This novel VSD with a negative pressure suction dressing is beneficial for healing infectious wounds.
Graphical Abstract
Reconstruction of rabbit mandibular bone defects using carbonate apatite honeycomb blocks with an interconnected porous structure
Authors: Kudoh Keiko , Fukuda Naoyuki , Akita Kazuya , Kudoh Takaharu , Takamaru Natsumi , Kurio Naito , Hayashi Koichiro , Ishikawa Kunio , Miyamoto Youji 
Published: December 2022

AbstractCarbonate apatite (CO3Ap) granules are useful as a bone substitute because they can be remodeled to new natural bone in a manner that conforms to the bone remodeling process. However, reconstructing large bone defects using CO3Ap granules is difficult because of their granular shape. Therefore, we fabricated CO3Ap honeycomb blocks (HCBs) with continuous unidirectional pores. We aimed to elucidate the tissue response and availability of CO3Ap HCBs in the reconstruction of rabbit mandibular bone defects after marginal mandibulectomy. The percentages of the remaining CO3Ap area and calcified bone area (newly formed bone) were estimated from the histological images. CO3Ap area was 49.1 ± 4.9%, 30.3 ± 3.5%, and 25.5 ± 8.8%, whereas newly formed bone area was 3.0 ± 0.6%, 24.3 ± 3.3%, and 34.7 ± 4.8% at 4, 8, and 12 weeks, respectively, after implantation. Thus, CO3Ap HCBs were gradually resorbed and replaced by new bone. The newly formed bone penetrated most of the pores in the CO3Ap HCBs at 12 weeks after implantation. By contrast, the granulation tissue scarcely invaded the CO3Ap HCBs. Some osteoclasts invaded the wall of CO3Ap HCBs, making resorption pits. Furthermore, many osteoblasts were found on the newly formed bone, indicating ongoing bone remodeling. Blood vessels were also formed inside most of the pores in the CO3Ap HCBs. These findings suggest that CO3Ap HCBs have good osteoconductivity and can be used for the reconstruction of large mandibular bone defects.
Graphical Abstract
Geographies of Care: The Catholic Church in Poland’s Assistance to Refugees from Ukraine During Russia’s Invasion of Ukraine
Authors: Mróz Franciszek 
Published: December 2022

AbstractThe purpose of the article was to analyze the collected empirical material in the form of in-depth interviews, observations, statistical data, and numerous accounts of the assistance of the Catholic Church in Poland in the first 8 months of Russia’s invasion of Ukraine. The results of the survey revealed that the Catholic Church’s activities and support to Ukrainians were carried out on many levels: charitable—mainly material, financial and social housing assistance, psychological, educational, and medical. All Catholic parishes and almost all women’s and men’s convents and monasteries in Poland, Caritas Poland, as well as dozens of church institutions, joined in helping refugees from Ukraine.
Rapid synthesis of MCM-41 and SBA-15 by microwave irradiation: promising adsorbents for CO2 adsorption
Authors: Oliveira Marília R. , Cecilia Juan A. , De Conto Juliana F. , Egues Silvia M. , Rodríguez-Castellón Enrique 
Published: December 2022

Abstract
It is known that the world scenario is one of constant search for sustainable technologies that can reduce the emission of carbon dioxide (CO2) in the atmosphere. This is because CO2 is seen as the main responsible for the increase in the generation of greenhouse gases, which leads to global warming and climate change. The development of efficient adsorbents for CO2 capture is a current challenge. MCM-41 and SBA-15 were synthesized in a microwave reactor and used as adsorbents in this work. Microwave irradiation presents itself as an easy synthesis strategy with less preparation time and energy requirement. The silica synthesis period was extremely reduced (1 h) at a temperature of 60 and 80 °C in the microwave reactor, obtaining silica with good textural and chemical properties. The CO2 adsorption isotherms were performed at 0, 25, and 40 °C at 1 bar. The MCM-41 and SBA-15 present favorable results for CO2 capture processes, showing that pure silica synthesized by microwave already obtains promising results, reaching a maximum adsorption capacity of 2.16 mmol g−1 (1 bar—0 °C) and a good fit for the Langmuir, DsL and Toth models. Furthermore, to increase CO2 adsorption, the mesoporous silica was also modified via impregnation with branched polyethylene diamine (PEI) or tetraethylenepentamine (TEPA). It is worth mentioning that microwave irradiation reduced the synthesis steps and improved the properties and adsorption capacity of the silica. This work opens new opportunities in the efficient preparation of materials that require optimizing the adsorbent synthesis process.

Graphical Abstract
The Architecture of Early Childhood Sleep Over the First Two Years
Authors: Lenehan Sonia Marie , Fogarty Leanna , O’Connor Cathal , Mathieson Sean , Boylan Geraldine B. 
Published: December 2022

Abstract
Introduction
The architecture and function of sleep during infancy and early childhood has not been fully described in the scientific literature. The impact of early sleep disruption on cognitive and physical development is also under-studied. The aim of this review was to investigate early childhood sleep development over the first two years and its association with neurodevelopment.

Methods
This review was conducted according to the 2009 PRISMA guidelines. Four databases (OVID Medline, Pubmed, CINAHL, and Web of Science) were searched according to predefined search terms.

Results
Ninety-three studies with approximately 90,000 subjects from demographically diverse backgrounds were included in this review. Sleep is the predominant state at birth. There is an increase in NREM and a decrease in REM sleep during the first two years. Changes in sleep architecture occur in tandem with development. There are more studies exploring sleep and early infancy compared to mid and late infancy and early childhood.

Discussion
Sleep is critical for memory, learning, and socio-emotional development. Future longitudinal studies in infants and young children should focus on sleep architecture at each month of life to establish the emergence of key characteristics, especially from 7–24 months of age, during periods of rapid neurodevelopmental progress.
The Unequal Effects of the COVID-19 Pandemic on Political Interest Representation
Authors: Eady Gregory , Rasmussen Anne 
Published: December 2022

AbstractThe COVID-19 pandemic is viewed by many as the biggest global crisis since WWII and had profound effects on the daily lives of people and decision-making worldwide. Using the pandemic as a system-wide agenda shock, we employ a difference-in-differences design to estimate its causal effects on inequalities in political access, and social media prominence among business interests and NGOs. Our argument is twofold. First, the urgency and uncertainty of crises incentivized decision-makers to privilege providing access to business groups over securing inclusivity in the types of interests consulted. Second, NGOs compensated by increasing prominence in public communications. Our analysis of data from over 10,000 interest groups from over 100 countries registered in the European Union supports these hypotheses. Business interests successfully capitalized on the crisis in insider access, while NGOs increased prominence on social media. The results have wider implications for understanding how large-scale crises affect inequalities in representation.
On the predictions of cumulative prospect theory for third and fourth order risk preferences
Authors: Paya Ivan , Peel David A. , Georgalos Konstantinos 
Published: December 2022

AbstractIn this paper, we analyse higher-order risky choices by the representative cumulative prospect theory (CPT) decision maker from three alternative reference points. These are the status quo, average payout and maxmin. The choice tasks we consider in our analysis include binary risks, and are the ones employed in the experimental literature on higher order risk preferences. We demonstrate that the choices made by the representative subject depend on the reference point. If the reference point is the status quo and the lottery choices exhibit symmetric risk, we demonstrate that there is no third order reflection effect of lottery choices but there is a fourth order reflection effect. When the average payout is the reference point, we demonstrate that any third or fourth order lottery choice is possible dependent upon the lottery payoffs. However, under the assumption of maxmin reference point, the risky choices are prudent and temperate. In addition to these results, our analysis reveals that the representative CPT subject can choose combinations of second with third and fourth order risky options that differ from those in other major models of decision under risk. We contrast our theoretical predictions with the empirical results reported in the literature on higher order risk preferences and are able to reconcile some conflicting experimental evidence.
Stressful Events, Psychological Distress and Well-Being during the Second Wave of COVID-19 Pandemic in Spain: A Gender Analysis
Authors: Pilar Matud M. , del Pino Mª José , Bethencourt Juan Manuel , Estefanía Lorenzo D. 
Published: December 2022

Abstract
The present study investigates gender differences in stressful events, psychological distress and well-being during the second wave of COVID-19 in Spain, analyzing women’s and men’s risk and resilience factors for psychological distress and for well-being. Participants were 1758 individuals from the general population, 50.8% women, aged between 18 and 79 years. Women and men did not differ in age, number of children, educational level, occupation or marital status. The participants were assessed by seven self-report questionnaires and scales. The results revealed that women experienced more psychological distress, more negative feelings, more stressful events related to the COVID-19 pandemic, more social support, and lower thriving and self-esteem than men. Multiple regression analyses showed that, in the case of women and men as well, self-esteem was the most important predictor of higher well-being and lower psychological distress and negative feelings while more COVID-19 pandemic-related stressful events were associated with higher psychological distress and lower well-being. Another important predictor of greater well-being for either gender was social support while unemployment was associated with lower well-being. In women and men, a higher educational level was associated with greater psychological distress and negative feelings; the male sample revealed that psychological distress was also connected to younger age while in women it was associated with lower instrumental social support. The results suggest that gender plays an important role in the mental health effects of the COVID-19 pandemic, with the risk being higher for women than for men.
Predicted cardiac and second cancer risks for patients undergoing VMAT for mediastinal Hodgkin lymphoma
Authors: Houlihan Orla A. , Ntentas Georgios , Cutter David J. , Daly Patricia , Gillham Charles , McArdle Orla , Duane Frances K. 
Published: December 2022

Abstract
Background and purpose
To predict treatment-related cardiovascular disease (CVD) and second cancer 30-year absolute mortality risks (AMR30) for patients with mediastinal Hodgkin lymphoma in a large multicentre radiation oncology network in Ireland.

Material and methods
This study includes consecutive patients treated for mediastinal lymphoma using chemotherapy and involved site radiotherapy (RT) 2016–2019. Radiation doses to heart, left ventricle, cardiac valves, lungs, oesophagus, carotid arteries and female breasts were calculated. Individual CVD and second cancer AMR30 were predicted using Irish background population rates and dose–response relationships.

Results
Forty-four patients with Hodgkin lymphoma were identified, 23 females, median age 28 years. Ninety-eight percent received anthracycline, 80% received 4–6 cycles ABVD. Volumetric modulated arc therapy (VMAT) ± deep inspiration breath hold (DIBH) was delivered, median total prescribed dose 30 Gy. Average mean heart dose 9.8 Gy (range 0.2–23.8 Gy). Excess treatment-related mean AMR30 from CVD was 2.18% (0.79, 0.90, 0.01, 0.13 and 0.35% for coronary disease, heart failure, valvular disease, stroke and other cardiac diseases), 1.07% due to chemotherapy and a further 1.11% from RT. Excess mean AMR30 for second cancers following RT were: lung cancer 2.20%, breast cancer in females 0.34%, and oesophageal cancer 0.28%.

Conclusion
For patients with mediastinal lymphoma excess mortality risks from CVD and second cancers remain clinically significant despite contemporary chemotherapy and photon-RT. Efforts to reduce the toxicity of combined modality treatment, for example, using DIBH, reduced margins and advanced RT, e.g. proton beam therapy, should be continued to further reduce potentially fatal treatment effects.
Promising Molecular Targets and Novel Therapeutic Approaches in Neuroblastoma
Authors: Yang Xu , Li Jixia , Yang Jigang 
Published: December 2022

Abstract
Purpose of Review

This article provides a brief and up-to-date overview of promising molecular targets and novel therapeutic approaches in neuroblastoma (NB).

Recent Findings
High-risk NB is hard to manage with existing treatment modalities, so more than half of those cases are unable to achieve long-term survival. With a deep understanding of molecular pathogenesis, numerous therapeutic targets have been discovered, offering a wide range of novel strategies to treat high-risk NB. Several molecular targets or pathways of NB are well studied, such as GD2, MYCN, ALK, p53/MDM2, PI3K/Akt/mTOR/, and RAS/MAPK signaling. Novel targeted drugs and combined therapies are being developed and investigated for treating high-risk NB in preclinical and clinical trials. Considering different NB patients respond to molecular-guided therapy and conventional therapy differently, how to design an effective personalized therapy remains a big challenge.

Summary
Anti-GD2 monoclonal antibodies have been approved to treat high-risk NB. Inhibitors targeting MYCN, ALK, p53/MDM2, RAS/MAPK, and PI3K/Akt/mTOR are being tested in phase I/II clinical trials. However, most research on molecularly targeted therapy stays at the preclinical level. More valuable targets need to be identified, and more efficient therapies need to be developed. Further, exploration of new combinations using inhibitors targeting multiple targets and conventional therapy is still the most important research direction in future, which would advance treatment regimens, improve outcomes, and prolong survival in children with high-risk NB.
A Self-Powered, Highly Embedded and Sensitive Tribo-Label-Sensor for the Fast and Stable Label Printer
Authors: Hui Xindan , Li Zhongjie , Tang Lirong , Sun Jianfeng , Hou Xingzhe , Chen Jie , Peng Yan , Wu Zhiyi , Guo Hengyu 
Published: December 2022

AbstractLabel-sensor is an essential component of the label printer which is becoming a most significant tool for the development of Internet of Things (IoT). However, some drawbacks of the traditional infrared label-sensor make the printer fail to realize the high-speed recognition of labels as well as stable printing. Herein, we propose a self-powered and highly sensitive tribo-label-sensor (TLS) for accurate label identification, positioning and counting by embedding triboelectric nanogenerator into the indispensable roller structure of a label printer. The sensing mechanism, device parameters and deep comparison with infrared sensor are systematically studied both in theory and experiment. As the results, TLS delivers 6 times higher signal magnitude than traditional one. Moreover, TLS is immune to label jitter and temperature variation during fast printing and can also be used for transparent label directly and shows long-term robustness. This work may provide an alternative toolkit with outstanding advantages to improve current label printer and further promote the development of IoT.
Novel role of AMPK in cocaine reinforcement via regulating CRTC1
Authors: Liu Xiao-Xing , Liu Fang-Lin , Li Xin , Lu Tang-Sheng , Luo Yi-Xiao , Jian Min , Yuan Kai , Meng Shi-Qiu , Bao Yan-Ping , Shi Jie , Lu Lin , Han Ying 
Published: December 2022

AbstractRepeated cocaine exposure causes compensatory neuroadaptations in neurons in the nucleus accumbens (NAc), a region that mediates reinforcing effects of drugs. Previous studies suggested a role for adenosine monophosphate-activated protein kinase (AMPK), a cellular energy sensor, in modulating neuronal morphology and membrane excitability. However, the potential involvement of AMPK in cocaine use disorder is still unclear. The present study employed a cocaine self-administration model in rats to investigate the effect of AMPK and its target cyclic adenosine monophosphate response element binding protein-regulated transcriptional co-activator 1 (CRTC1) on cocaine reinforcement and the motivation for cocaine. We found that intravenous cocaine self-administration significantly decreased AMPK activity in the NAc shell (NAcsh), which persisted for at least 7 days of withdrawal. Cocaine reinforcement, reflected by self-administration behavior, was significantly prevented or enhanced by augmenting or suppressing AMPK activity pharmacologically and genetically, respectively. No difference in sucrose self-administration behavior was found after the same manipulations. The inhibition of AMPK activity in the NAcsh also increased the motivation for cocaine in progressive-ratio schedules of reinforcement, whereas the activation of AMPK had no effect. The knockdown of CRTC1 in the NAcsh significantly impaired cocaine reinforcement, which was rescued by pharmacologically increasing AMPK activity. Altogether, these results indicate that AMPK in the NAcsh is critical for cocaine reinforcement, possibly via the regulation of CRTC1 signaling. These findings may help reveal potential therapeutic targets and have important implications for the treatment of cocaine use disorder and relapse.
Nonnegative spatial factorization applied to spatial genomics
Authors: Townes F. William , Engelhardt Barbara E. 
Published: December 2022

AbstractNonnegative matrix factorization (NMF) is widely used to analyze high-dimensional count data because, in contrast to real-valued alternatives such as factor analysis, it produces an interpretable parts-based representation. However, in applications such as spatial transcriptomics, NMF fails to incorporate known structure between observations. Here, we present nonnegative spatial factorization (NSF), a spatially-aware probabilistic dimension reduction model based on transformed Gaussian processes that naturally encourages sparsity and scales to tens of thousands of observations. NSF recovers ground truth factors more accurately than real-valued alternatives such as MEFISTO in simulations, and has lower out-of-sample prediction error than probabilistic NMF on three spatial transcriptomics datasets from mouse brain and liver. Since not all patterns of gene expression have spatial correlations, we also propose a hybrid extension of NSF that combines spatial and nonspatial components, enabling quantification of spatial importance for both observations and features. A TensorFlow implementation of NSF is available from https://github.com/willtownes/nsf-paper.
Evaluation of age-specific causes of death in the context of the Italian longevity transition
Authors: Nigri Andrea , Aburto José Manuel , Basellini Ugofilippo , Bonetti Marco 
Published: December 2022

AbstractIn many low-mortality countries, life expectancy at birth increased steadily over the last century. In particular, both Italian females and males benefited from faster improvements in mortality compared to other high-income countries, especially from the 1960s, leading to an exceptional increase in life expectancy. However, Italy has not become the leader in longevity. Here, we investigate life expectancy trends in Italy during the period 1960–2015 for both sexes. Additionally, we contribute to the existing literature by complementing life expectancy with an indicator of dispersion in ages at death, also known as lifespan inequality. Lifespan inequality underlies heterogeneity over age in populating health improvements and is a marker of uncertainty in the timing of death. We further quantify the contributions of different age groups and causes of death to recent trends in life expectancy and lifespan inequality. Our findings highlight the contributions of cardiovascular diseases and neoplasms to the recent increase in life expectancy but not necessarily to the decrease in lifespan inequality. Our results also uncover a more recent challenge across Italy: worsening mortality from infectious diseases and mortality at older age.