bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mesh quality agglomeration algorithm for the virtual element method applied to discrete fracture networks
Authors: Sorgente Tommaso , Vicini Fabio , Berrone Stefano , Biasotti Silvia , Manzini Gianmarco , Spagnuolo Michela 
Published: April 2023

AbstractWe propose a quality-based optimization strategy to reduce the total number of degrees of freedom associated with a discrete problem defined over a polygonal tessellation with the Virtual Element Method. The presented Quality Agglomeration algorithm relies only on the geometrical properties of the problem polygonal mesh, agglomerating groups of neighboring elements. We test this approach in the context of fractured porous media, in which the generation of a global conforming mesh on a Discrete Fracture Network leads to a considerable number of unknowns, due to the presence of highly complex geometries (e.g. thin triangles, large angles, small edges) and the significant size of the computational domains. We show the efficiency and the robustness of our approach, applied independently on each fracture for different network configurations, exploiting the flexibility of the Virtual Element Method in handling general polygonal elements.
A single institution’s experience with minimally invasive surgery for ovarian cancer, and a systematic meta-analysis of the literature
Authors: Kamei Yuji , Kobayashi Eiji , Nakatani Eiji , Shiomi Mayu , Sawada Masaaki , Kakuda Mamoru , Toda Aska , Nakagawa Satoshi , Hiramatsu Kosuke , Kinose Yasuto , Takiuchi Tsuyoshi , Miyoshi Ai , Kodama Michiko , Hashimoto Kae , Kimura Toshihiro , Ueda Yutaka , Sawada Kenjiro , Kimura Tadashi 
Published: April 2023

Abstract
Background
This study assesses the feasibility of minimally invasive surgery (MIS) for well-selected epithelial ovarian cancer (EOC) patients.

Methods
We performed a review of data prospectively collected from a single center from 2017 to 2022. Only patients with histologically confirmed EOC, with a tumor diameter of less than 10 cm, were eligible. We also performed a meta-analysis of similar studies comparing the outcomes of laparoscopy and laparotomy. We used MINORS (Methodological Index for Non-Randomized Studies) to assess the risk of bias and calculated the odds ratio or mean difference.

Results
Eighteen patients were included; 13 in re-staging group, four in PDS group, and one in IDS group. All achieved complete cytoreduction. One case was converted to laparotomy. The median number of removed pelvic lymph nodes was 25 (range 16–34), and 32 (range 19–44) for para-aortic nodes. There were two (15.4%) intraoperative urinary tract injuries. The median follow-up was 35 months (range 1–53). Recurrence was observed in one case (7.7%). Thirteen articles for early-stage ovarian cancer were included in our meta-analysis. Analysis of the pooled results found that MIS had a higher frequency of spillage (OR, 2.15; 95% CI 1.27–3.64). No differences were observed in recurrence, complications, or up-staging.

Conclusions
Our experience supports the possibility of conducting MIS for EOC in well-selected patients. Except for spillage, our meta-analysis findings are consistent with previous reports, the majority of which were also retrospective. Ultimately, randomized clinical trials will be needed to authenticate the safety.
Deontic signs increase control monitoring: evidence from a modified traffic flanker task
Authors: Garcia-Marques Teresa , Figueira Pedro , Fernandes Alexandre , Martins João 
Published: April 2023

AbstractDeontic norms are expected to impose individuals’ control over their behavior. In this paper, we address such norms presented in traffic signs and test their influence over executive control functions. For Experiment 1, we develop a traffic flanker task in which the typical neutral arrows are replaced with traffic prohibition/obligation signs. Experiment 2 isolated the deontic aspect of the signs using simple arrows on red, blue, and green backgrounds and either primed them to be interpreted as traffic signs or as elements of a gaming console controller. Results in both studies show evidence of controlling context interferences more efficiently when dealing with deontic (traffic) signs than with simple arrows (Experiment 1) or with similar perceptive targets when primed with a deontic context than with a gaming context (Experiment 2). In both studies, obligation/blue signs mitigate flanker effects less than prohibition/red signs. Stimuli color affects the alertness of the cognitive system, with the color red being, by itself, a cue for increased control. Based on temporal analysis, we further discuss these results as evidence of an increase in proactive control that aims to prevent the occurrence of undesirable influence.
Australian Youth Mental Health and Climate Change Concern After the Black Summer Bushfires
Authors: Lykins Amy D. , Parsons Melissa , Craig Belinda M. , Cosh Suzanne M. , Hine Donald W. , Murray Clara 
Published: April 2023

AbstractClimate change and its effects present notable challenges for mental health, particularly for vulnerable populations, including young people. Immediately following the unprecedented Black Summer bushfire season of 2019/2020, 746 Australians (aged 16–25 years) completed measures of mental health and perceptions of climate change. Results indicated greater presentations of depression, anxiety, stress, adjustment disorder symptoms, substance abuse, and climate change distress and concern, as well as lower psychological resilience and perceived distance to climate change, in participants with direct exposure to these bushfires. Findings highlight significant vulnerabilities of concern for youth mental health as climate change advances.
Optimal chemical defence allocation in roots: where, why and how?
Authors: Touw Axel J. , van Dam Nicole M. 
Published: April 2023

Abstract
Plants produce a range of volatile and non-volatile plant secondary metabolites (PSMs) to increase their resistance to biotic threats. The optimal defence allocation theory (ODT) states that the most valuable and vulnerable plant organs should be best defended against herbivory and therefore contain high concentrations of PSMs. However, the production of PSMs can come with metabolic and ecological costs and should be adjusted to the predictability and nature of biotic interactions to minimise interference with the ecological functions of the tissue. The ODT has recently been extended to explain PSM allocation patterns over root organs. Recent research has revealed that valuable but vulnerable root classes, such as taproots or adventitious roots, indeed have higher levels of anti-herbivory PSMs than lateral or fine roots. In this perspective, we analyse how interactions with soil organisms, including insect herbivores and microorganisms, may shape PSM allocation patterns in roots. We thereby focus on the Brassicaceae family and the glucosinolate-myrosinase defence system, but also highlight relevant studies in other species. We summarise the state-of-the-art knowledge of GSL distribution patterns over the plant body, discuss potential drivers of PSM allocation and discuss which mechanisms might regulate constitutive and induced PSM allocation patterns. Finally, we argue that implementing microbial interactions into ODT will improve our understanding of the eco-evolutionary drivers of plant–insect interactions.
Charting fields and spaces quantitatively: from multiple correspondence analysis to categorical principal components analysis
Authors: Atkinson Will 
Published: April 2023

AbstractMultiple correspondence analysis (MCA) has started to gain popularity within sociology as a method of mapping ‘fields’ and ‘social spaces’ in the style of Pierre Bourdieu, its capacity to document multidimensional geometric relationships within data being a snug fit for the relational mode of thought he championed. There is a risk, however, of over-relying on MCA when the data suggest alternative methods and, as a result, drawing unsound conclusions. As a case in point, I take a recent analysis of political attitudes in the UK using MCA that drew bold inferences about the relationship with social class and reanalyse the same data with categorical principal components analysis (CatPCA). The results suggest the opposite conclusion to what was originally argued. I thus urge greater methodological flexibility and openness among those wishing to chart fields and social spaces and, more specifically, I make a case for CatPCA as a tool of geometric data analysis.
Ecosystem Vulnerability. New Semantics for International Law
Authors: Longo Mariano , Lorubbio Vincenzo 
Published: April 2023

AbstractThe effects of climate change and increasing environmental pollution have clearly shown the vulnerability of individuals, local communities, and the natural environment, even in the Western context. However, despite such unquestionable data, International Law is still struggling to find adequate, unambiguous, effective solutions to the issue. Even the ‘human right to a healthy environment’, recognised by the UN General Assembly in 2022, is permeated by an anthropocentric idea of the world, which prevents it from fully dealing with ecosystem issues so as to protect any living and non-living being. The paper starts by exploring the historical relevance of the concept of limit and the lack of boundaries in contemporary society, aiming to show that new semantics are needed, in order to overcome contemporary extractivism. An analysis of international legislation and jurisprudence will investigate the role that the concept of ecosystem vulnerability might play in the implementation of both human rights and the rights of nature.
Comparison of different anastomosis angles in radiocephalic fistula with modified functional end-to-side anastomosis
Authors: Xu Wei , Lu Guoyuan , Tang Weigang , Gong Lifeng , Lu Jingkui 
Published: April 2023

Abstract
Objective
Functional vein end to arterial side (ETS) anastomosis uses vein side to arterial side anastomosis with distal vein ligation, which is different from traditional ETS anastomosis. To date, there are no studies concerning different anastomotic angles of fistula with functional ETS anastomosis. The purpose of the study was to analyze the clinical outcomes concerning different anastomotic angles of functional ETS anastomosis in radiocephalic fistula.

Methods
Between January 2018 and December 2020, we performed a prospective cohort study concerning functional ETS anastomosis in radiocephalic fistula. According to vascular anatomy of patients, the anastomosis angles of fistula were designed at 30 ≤ angle ≤ 50°, 50 < angle ≤ 70°, and 135° smooth obtuse angle. The end points were the primary patency rate (PPR), the secondary patency rate (SPR) and the cumulative rate of reintervention (CRR) near anastomotic venous segment.

Results
124 patients with functional ETS anastomosiss were enrolled in this study. Pearson χ2 test showed that the group of 135°anastomosis angle had the maximum distance between arteries and veins, and the group of 30–50°anastomosis angle had the minimum distance between arteries and veins (P < 0.01). 30–50°anastomosis angle had the highest PPR at 12 months (P = 0.03) and the lowest CRR near anastomotic venous segment at 3 months (P = 0.04) and 12 months (P = 0.01). There were no significant differences among different anastomosis angles concerning the SPR within 12 months (P > 0.05). Kaplan–Meier and log-rank analysis showed that 30–50°anastomosis had the highest PPR (P = 0.03) and the lowest CRR near anastomotic venous segment (P = 0.01). A multivariable Cox model showed anastomotic angle was an independent factor predictive of the PPR (P = 0.04) and the CRR near anastomotic venous segment (P = 0.03). 50–70°anastomosis angle was a risk factor of decreasing PPR (P = 0.03). 50–70° (P = 0.01) and 135° (P = 0.03) anastomosis angle were both obvious risk factors of increasing CRR near anastomotic venous segment.

Conclusion
30–50°were the best anastomotic angles for functional ETS anastomosis, which had the highest PPR and lowest CRR near anastomotic venous segment.
Nanotechnology in agriculture: a review of genotoxic studies of nanopesticides in animal cells
Authors: Paz-Trejo Cynthia , Flores-Márquez Ana Rosa , Gómez-Arroyo Sandra 
Published: April 2023

Abstract
Agriculture has been and still is one of the most influential primary operations in economic history worldwide. Its social, cultural, and political impact allows the progression and survival of humanity. Sustaining the supply of primary resources is crucial for the future. Therefore, the development of new technologies applied to agrochemicals is growing to obtain better food quality faster. Recently, nanotechnology has gained strength in this field in the last decade, mainly because of the presumed benefits that will carry with it compared with the current commercial presentations, like the decrease of risk in non-target organisms. The harm of pesticides is commonly associated with unwanted effects on human health, some with long-term genotoxic effects. Therefore, it would be relevant to set the existence of a risk or a benefit of the nanopesticides from a genotoxic point of view, comparing against those without this technology. Although some studies are concerned with its genotoxicity in live aquatic organisms, few focus on human in vitro models. Several studies conclude that some of them can induce oxidative stress, leading to DNA damage or cell death. However, there is still much to investigate to establish an accurate and complete assessment. In this review, we aim to give an overview of the genotoxic effect caused by nanopesticides in animal cells and a guide to the evolution of this topic, offering a base and critical review to facilitate future research.
Phytoremediation potential depends on the degree of soil pollution: a case study in an urban brownfield
Authors: Fernández-Braña Alicia , Salgado Lorena , Gallego José Luis R. , Afif Elías , Boente Carlos , Forján Rubén 
Published: April 2023

AbstractPhytoremediation is a cost-effective nature-based solution for brownfield reclamation. The choice of phytoextraction or phytostabilization strategies is highly relevant when planning full-scale treatments. A suitable approach to identify such species involves the evaluation of plants that grow spontaneously on the contaminated sites. Here, we sought to determine the phytoremediation potential of three spontaneous plant species, namely the trees Acer pseudoplatanus L (A. pseudoplatanus) and Betula celtiberica Rothm. & Vasc (B. celtiberica), and the shrub Buddleja davidii Franch (B. davidii), for the recovery of an urban brownfield. To determine the response of the species to the degree of contamination, we conducted soil and vegetation sampling inside and outside the site. The concentrations of As, Cu, and Zn in soil and plant samples were measured, and then various indexes related to phytoremediation were calculated. The translocation factor and transfer coefficient indicated that vegetation outside the brownfield had phytoextraction capacity while the same plants inside the brownfield revealed phytostabilization properties. Given our results, we propose that the selected species are suitable for phytostabilization strategies in areas with high concentrations of contaminants, whereas they could be used for phytoextraction only in soils with low or moderate levels of pollution.
Graphical Abstract
Machine learning-based detection and mapping of riverine litter utilizing Sentinel-2 imagery
Authors: Mohsen Ahmed , Kiss Tímea , Kovács Ferenc 
Published: April 2023

AbstractDespite the substantial impact of rivers on the global marine litter problem, riverine litter has been accorded inadequate consideration. Therefore, our objective was to detect riverine litter by utilizing middle-scale multispectral satellite images and machine learning (ML), with the Tisza River (Hungary) as a study area. The Very High Resolution (VHR) images obtained from the Google Earth database were employed to recognize some riverine litter spots (a blend of anthropogenic and natural substances). These litter spots served as the basis for training and validating five supervised machine-learning algorithms based on Sentinel-2 images [Artificial Neural Network (ANN), Support Vector Classifier (SVC), Random Forest (RF), Naïve Bays (NB) and Decision Tree (DT)]. To evaluate the generalization capability of the developed models, they were tested on larger unseen data under varying hydrological conditions and with different litter sizes. Besides the best-performing model was used to investigate the spatio-temporal variations of riverine litter in the Middel Tisza. According to the results, almost all the developed models showed favorable metrics based on the validation dataset (e.g., F1-score; SVC: 0.94, ANN: 0.93, RF: 0.91, DT: 0.90, and NB: 0.83); however, during the testing process, they showed medium (e.g., F1-score; RF:0.69, SVC: 0.62; ANN: 0.62) to poor performance (e.g., F1-score; NB: 0.48; DT: 0.45). The capability of all models to detect litter was bounded to the pixel size of the Sentinel-2 images. Based on the spatio-temporal investigation, hydraulic structures (e.g., Kisköre Dam) are the greatest litter accumulation spots. Although the highest transport rate of litter occurs during floods, the largest litter spot area upstream of the Kisköre Dam was observed at low stages in summer. This study represents a preliminary step in the automatic detection of riverine litter; therefore, additional research incorporating a larger dataset with more representative small litter spots, as well as finer spatial resolution images is necessary.
Dipeptidyl peptidase 4 inhibitor reduces tumor-associated macrophages and enhances anti-PD-L1-mediated tumor suppression in non-small cell lung cancer
Authors: Zuo Bei , Li Tao , Liu Xiaoyun , Wang Shuling , Cheng Jianxiang , Liu Xiangqun , Cui Wenjie , Shi Hengliang , Ling Chunhua 
Published: April 2023

Abstract
Purpose
The efficacy of immune checkpoint inhibitors such as programmed cell death ligand 1 (PD-L1) antibodies in non-small cell lung cancer (NSCLC) is limited, and combined use with other therapies is recommended. Dipeptidyl peptidase 4 (DPP4) inhibitors, a class of small molecule inhibitors, are highly effective for treating type 2 diabetes. Emerging evidence implicates DPP4 inhibitors as immunomodulators that modify aspects of innate and adaptive immunity. We evaluated the combination of a DPP4 inhibitor (anagliptin) and PD-L1 blockade in an NSCLC mouse model.

Methods
The effect of the combination of anti-PD-L1 and anagliptin was evaluated in subcutaneous mouse models of NSCLC. Tumor-infiltrating immune cells were analyzed by flow cytometry. Bone marrow-derived monocytes of C57BL/6 mice were isolated in vitro to examine the underlying mechanism of anagliptin on the differentiation and polarization of macrophage.

Results
Anagliptin dramatically improved the efficacy of PD-L1 antibody monotherapy by inhibiting macrophage formation and M2 polarization in the tumor microenvironment. Mechanistically, anagliptin suppressed the production of reactive oxygen species in bone marrow monocytes by inhibiting NOX1 and NOX2 expression induced by macrophage colony-stimulating factor, reduced late ERK signaling pathway activation, and inhibited monocyte-macrophage differentiation. However, the inhibitory effect was reactivated by lipopolysaccharide and interferon-gamma interacting with corresponding receptors during M1 macrophage polarization, but not M2.

Conclusions
Anagliptin can enhance PD-L1 blockade efficacy in NSCLC by inhibiting macrophage differentiation and M2 macrophage polarization, and combination therapy may be a promising strategy for treating PD-L1 blockade therapy-resistant patients with NSCLC.
Wirksamkeit institutioneller Prävention und Intervention bei sexualisierter Gewalt
Authors: Grieser Felicia , Wazlawik Martin , Derr Regine , Eppinger Sabeth , Kindler Heinz 
Published: April 2023

ZusammenfassungAusgangspunkt des Forschungsvorhabens SchuLae bildet die angestrebte flächendeckende Einführung institutioneller Schutzkonzepte in pädagogischen Kontexten. Im Zuge eines durch Schutzkonzepte in Gang gesetzten Organisationsentwicklungsprozesses sollen Orte des Aufwachsens für Kinder und Jugendliche zu Schutz- und Kompetenzorten werden. Ob Schutzkonzepte tatsächlich zu einem Rückgang von Viktimisierungserfahrungen und einer erhöhten Bereitschaft zur Hilfe(suche) führen, wurde bislang nicht empirisch erfasst. Der vom Bundesministerium für Bildung und Forschung (BMBF) geförderte Verbund „SchuLae – Entwicklung und Wirkung von Schutzkonzepten in Schulen im Längsschnitt“ des Deutschen Jugendinstituts und der Hochschule Hannover untersucht daher die Wirksamkeit schulischer Schutzkonzepte sowohl quantitativ als auch qualitativ im Längsschnitt und fokussiert dabei die Perspektiven von Schüler*innen.
Assessment of Bone Health Awareness and Education in Breast Cancer Patients with Bone Metastasis in the USA
Authors: Flora Darcy R. , Schenfeld Jennifer , Saad Hossam , Cadieux Ben , Boike Guy , Lowe Kimberly A. 
Published: April 2023

AbstractBone metastases are common in advanced breast cancer (BC) patients and increase the risk for skeletal-related events (SREs), which present a significant health and economic burden. Bone targeting agents (BTAs) can improve health-related quality of life by delaying or preventing SREs; nevertheless, a significant portion of eligible BC patients are not receiving this therapy. A bone health education needs assessment survey was conducted to examine cancer-related bone health awareness and to identify opportunities to improve bone health education. Direct-to-patient outreach was used to recruit adult BC patients in the USA self-reporting a diagnosis of bone metastasis within the past 3 years. Of the 200 patients, 59% experienced at least one SRE prior to survey participation (44% radiation to bone, 29% bone fracture, 17% spinal cord compression, 15% surgery to bone), and 83% were currently receiving a BTA. Awareness of general cancer bone health, protection strategies against SREs, and screening tests were low to moderate. Patients currently not receiving a BTA were least knowledgeable about cancer bone health, with only 40% aware of BTAs as a protective strategy, and only 26% were very or extremely satisfied with the information received from healthcare providers. Sixty-two percent of patients wanted to receive information by more than one mode of communication. Notable gaps in bone health education were observed in bone metastatic BC patients at risk for SREs, suggesting the need for earlier and more effective communication and education strategies to promote appropriate BTA use and better health outcomes.
Contamination of tea leaves by anthraquinone: The atmosphere as a possible source
Authors: Li Cathy W. Y. , Walters Stacy , Müller Jean-François , Orlando John , Brasseur Guy P. 
Published: April 2023

AbstractThe detection of anthraquinone in tea leaves has raised concerns due to a potential health risk associated with this species. This led the European Union to impose a maximum residue limit (MRL) of 0.02 mg/kg for anthraquinone in dried tea leaves. As atmospheric contamination has been identified as one of the possible sources of anthraquinone residue, this study investigates the contamination resulting from the deposition of atmospheric anthraquinone using a global chemical transport model that accounts for the emission, atmospheric transport, chemical transformation, and deposition of anthraquinone on the surface. The largest contribution to the global atmospheric budget of anthraquinone is from residential combustion followed by the secondary formation from oxidation of anthracene. Simulations suggest that atmospheric anthraquinone deposition could be a substantial source of the anthraquinone found on tea leaves in several tea-producing regions, especially near highly industrialized and populated areas of southern and eastern Asia. The high level of anthraquinone deposition in these areas may result in residues in tea products exceeding the EU MRL. Additional contamination could also result from local tea production operations.