bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Intelligent Approach Based on Cleaning up of Inutile Contents for Extremism Detection and Classification in Social Networks
Authors: Berhoum Adel , Meftah Mohammed Charaf Eddine , Laouid Abdelkader , Hammoudeh Mohammad 
Published: January 2023

Extremism is a growing threat worldwide that presents a significant danger to public safety and national security. Social networks provide extremists with spaces to spread their ideas through commentaries or tweets, often in Asian English. In this paper, we propose an intelligent approach that cleans the text’s content, analyzes its sentiment, and extracts its features after converting it to digital data for machine learning treatments. We apply 16 intelligent machine learning classifiers for extremism detection and classification. The proposed artificial intelligence methods for Asian English language data are used to extract the essential features from the text. Our evaluation of the proposed model with an extremism dataset proves its effectiveness compared to the standard classification models based on various performance metrics. The proposed model achieves 93,6% accuracy for extremism detection and 97,0% for extremism classification.
Using Model Cloud Information to Reassign Low-Level Atmospheric Motion Vectors in the ECMWF Assimilation System
Authors: Lean Katie , Bormann Niels 
Published: January 2023

Abstract
This paper investigates the use of model cloud information in the assimilation of low-level atmospheric motion vectors (AMVs) in the ECMWF global data assimilation system, with the aim to characterize and address issues encountered in the assimilation of these observations. An analysis of background departure statistics (comparison of observations with the model background) shows that AMVs placed above the model cloud show larger deviations from the model background relative to those placed unrealistically close to the surface. Reassigning the pressure of AMVs diagnosed above the model cloud layer to either the model cloud top, cloud base, or average pressure leads to improvements in root-mean-square vector difference (RMSVD) and speed bias against the background wind fields. In assimilation experiments, reassigning AMVs placed above the model cloud to the model cloud top, cloud base, or average pressure results overall in a positive impact on subsequent forecasts. The reassignment to an average model cloud pressure performs best in this respect, and this approach has been implemented in the operational ECMWF system in October 2021.
Comparing the Contributions of Temperature and Salinity Changes to the AMOC Decline at 26.5°N
Authors: Lu Wenbo , Zhou Chun , Zhao Wei , Zhang Cunjie , Geng Tao , Xiao Xin 
Published: January 2023

Abstract
At 26.5°N in the North Atlantic, a continuous transbasin observational array has been established since 2004 to detect the strength of the Atlantic meridional overturning circulation. The observational record shows that the subtropical Atlantic meridional overturning circulation has weakened by 2.5 ± 1.5 Sv (as mean ± 95% interval; 1 Sv ≡ 106 m3 s−1) since 2008 compared to the initial 4-yr average. Strengthening of the upper southward geostrophic transport (with a 2.6 ± 1.6 Sv southward increase) derived from thermal wind dominates this Atlantic meridional overturning circulation decline. We decompose the geostrophic transport into its temperature and salinity components to compare their contributions to the transport variability. The contributions of temperature and salinity components to the southward geostrophic transport strengthening are 1.0 ± 2.5 and 1.6 ± 1.3 Sv, respectively. The variation of salinity component is significant at the 95% confidence level, while the temperature component’s variation is not. This result highlights the vital role that salinity plays in the subtropical Atlantic meridional overturning circulation variability, which has been overlooked in previous studies. We further analyze the geostrophic transport variations and their temperature and salinity components arising from different water masses, which shows that a warming signal in Labrador Sea Water and a freshening signal in Nordic Sea Water are two prominent sources of the geostrophic transport increase. Comparison of the temperature and salinity records of the 26.5°N array with the upstream records from repeated hydrographic sections across the Labrador Sea suggests that these thermohaline signals may be exported from the subpolar Atlantic via the deep western boundary current.
Scripps Argo Trajectory-Based Velocity Product: Global Estimates of Absolute Velocity Derived from Core, Biogeochemical, and Deep Argo Float Trajectories at Parking Depth
Authors: Zilberman N. V. , Scanderbeg M. , Gray A. R. , Oke P. R. 
Published: January 2023

Abstract
Global estimates of absolute velocities can be derived from Argo float trajectories during drift at parking depth. A new velocity dataset developed and maintained at Scripps Institution of Oceanography is presented based on all Core, Biogeochemical, and Deep Argo float trajectories collected between 2001 and 2020. Discrepancies between velocity estimates from the Scripps dataset and other existing products including YoMaHa and ANDRO are associated with quality control criteria, as well as selected parking depth and cycle time. In the Scripps product, over 1.3 million velocity estimates are used to reconstruct a time-mean velocity field for the 800–1200 dbar layer at 1° horizontal resolution. This dataset provides a benchmark to evaluate the veracity of the BRAN2020 reanalysis in representing the observed variability of absolute velocities and offers a compelling opportunity for improved characterization and representation in forecast and reanalysis systems.

Significance Statement
The aim of this study is to provide observation-based estimates of the large-scale, subsurface ocean circulation. We exploit the drift of autonomous profiling floats to carefully isolate the inferred circulation at the parking depth, and combine observations from over 11 000 floats, sampling between 2001 and 2020, to deliver a new dataset with unprecedented accuracy. The new estimates of subsurface currents are suitable for assessing global models, reanalyses, and forecasts, and for constraining ocean circulation in data-assimilating models.
Evaluation of the new Abbott®Alinity assay for the measurement of thyroglobulin antibodies in patients with differentiated thyroid carcinoma
Authors: Garcia Cano Ana M , Rosillo Coronado Marta , Alcázar García Laura , Gómez Lozano Ana , Carrasco Sayalero Angela , Rodriguez Torres Argeme 
Published: January 2023

Background Measurement of antithyroglobulin antibodies (TgAb) is important in patients with differentiated thyroid carcinoma (DTC) with total thyroidectomy. These patients are monitored based on serum thyroglobulin (Tg) levels. TgAb is known to interfere with the measurement of Tg by immunoassay. This study evaluates a new methodology for the measurement of TgAb Alinity Abbott® and the concordance with other methods (first and second generation Advia Centaur Systems Siemens® and Phadia 250 Thermofisher®). Methods The technical characteristics of Alinity TgAb measurement methodology were analysed, with imprecision and repeatable studies. In order to assess concordance, a minimum of 69 and a maximum of 76 samples from patients with DTC and total thyroidectomy were processed in parallel by several TgAb measurement methodologies. Agreement rates were determined using kappa statistics. The correlation between the four methods was examined pairwise using McNemar test analysis. Results The coefficients of variation (standard deviation as a percentage of the mean % CV) for the Alinity Abbott kit reagent TgAb were within 10% included the functional sensitivity. On the other hand, the concordance analysis with the kappa index concluded substantial agreement. The McNemar test showed a significant difference between Alinity versus Centaur second generation (difference 8.33%, CI 95% 0.68–8.33, p = .0313). Conclusion The new methodology for the measurement of TgAb meets the imprecision standards while presenting an adequate concordance agreement with other methodologies available in laboratories. It is important to define the functional sensitivity when reporting results so that they are as reliable as possible.
Developing and validating a highly sensitive platelet clump detection model for the Sysmex haematology analyser
Authors: Fang Kui , Chen Xiling , Dong Zheqing , Xu Peng 
Published: January 2023

Background Mainstream haematology analysers (HAs) are reported to have low detection sensitivity for platelet clumps. In this study, a deep learning (DL) algorithm, convolutional neural network (CNN), was implemented to detect platelet clumps. Methods Adenosine diphosphate (ADP) was used to induce platelet aggregation to mimic platelet clumps detected (PCD) samples. Six types of leukocyte scattergrams were collected from the Sysmex XN-10. Then, multiple CNNs were trained and validated by scattergrams in a fivefold cross-validation (CV) method. Finally, the CNN model with the best CV accuracy was tested with practical routine work samples. Results A total of 386 samples (190 PCD and 196 negative samples) and 4253 samples (150 PCD and 4103 negative samples) were eligible for CNN training and practical test, respectively. The CNN with the highest CV accuracy was trained by using scattergrams of side scatter (SSC) vs. forward scatter (FSC) from the white count and nucleated red blood cells (WNR) channel, whose mean area under the curve (AUC), accuracy, specificity and sensitivity were 0.968, 0.940, 0.937 and 0.942, respectively, in the CV. In the practical test, the AUC, accuracy, specificity and sensitivity of the CNN were 0.916, 0.961, 0.860 and 0.965, respectively. The dispersed spots presenting around the leucocytes in the WNR channel may be a sign of platelet clumping. Conclusions This study demonstrates that the CNN algorithms can identify platelet clumps based on optical information from dedicated leukocyte channels and has a higher ability to detect platelet clumps than the XN-10 device’s internal algorithm under practical circumstances.
Ankle Pain After Medial Opening-Wedge High Tibial Osteotomy in Patients With Knee Osteoarthritis and Concurrent Ankle Osteoarthritis
Authors: Kim Man Soo , Kim Jae Jung , Kang Ki Ho , Ihm Joon Soo , In Yong 
Published: January 2023

Background: Medial opening-wedge high tibial osteotomy (MOWHTO) in patients with varus knee osteoarthritis (OA) causes changes to ankle and hindfoot alignment. However, the compensatory ability of the ankle and hindfoot varies according to the severity of ankle OA. Purpose: To investigate whether the changes in ankle symptoms and ankle and hindfoot alignments differ after MOWHTO according to the severity of preoperative ankle OA. Study design: Case-control study; Level of evidence, 3. Methods: The data of 130 patients who were followed for ≥4 years were reviewed. Patients were classified into 2 groups according to their severity of ankle OA: group 1, modified Kellgren-Lawrence grade 0 and 1; group 2, grade ≥2. Four radiographic parameters were examined to evaluate ankle alignment: tibial plafond inclination, talar tilt, talar inclination, and tibial surface angle. The hindfoot alignment was evaluated using the varus-valgus angle (VVA) of the calcaneus. A visual analog scale (VAS) was used to evaluate ankle pain. The patient-reported outcome measure of the knee joint was the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score. Results: There were 110 patients in group 1 and 20 patients in group 2. In group 2, the change in talar inclination after MOWHTO was significantly greater and the changes in tibial plafond inclination, talar tilt, and VVA were significantly smaller compared with in group 1 (all P < .05). Ankle pain VAS scores were more severe in group 2 than in group 1 pre- and postoperatively (all P < .05), and group 2 reported that ankle pain worsened postoperatively ( P < .05). In both groups, knee WOMAC scores improved, and there were no differences between groups pre- or postoperatively (all P > .05). A multivariate regression analysis demonstrated that a small VVA change (odds ratio, 0.775; P = .027) and severe OA grade of the ankle joint preoperatively (Kellgren-Lawrence grades 2-4 vs 0 and 1; odds ratio, 4.241 [ P = .046]) predicted increased ankle pain VAS scores after MOWHTO. Conclusion: Although the patient-reported outcome measures for the knee joint improved irrespective of the presence of ankle OA, ankle pain worsened after MOWHTO in patients with ankle OA. Inadequate compensatory change in hindfoot alignment increased ankle pain in these patients.
Antimicrobial Resistance, Phenotypic Characteristics, and Biofilm Production in Citrobacter freundii Isolates Obtained from Urinary Tract Infections
Authors: Shinu Pottathil 
Published: January 2023

Objective To evaluate the link between phenotypic traits, antimicrobial resistance, and biofilm-producing capacity of urinary isolates of Citrobacter freundii ( C. freundii). Methods Both pan-antibiotic-susceptible and -resistant C. freundii isolates ( n = 120) obtained from laboratory-confirmed urinary tract infections were analyzed for their link between antimicrobial resistance, phenotypic characteristics, and biofilm production. Results Of the total C. freundii isolates ( n = 120), 30% (37/120) of them formed large colonies. Among the total large colonies produced ( n = 37), they were present in 21.62%, 10.81%, 13.5%, 16.2%, 21.62%, and 16.21% in the control group, CIP-group, FOS-group, COT-group, Gent-group, and ESBL groups, respectively. Compared to the pan-susceptible isolates, the occurrence of large-sized-colony-forming strains was relatively reduced in most of the drug-resistant groups. The overall distribution of mucoid colonies produced ( n = 54) includes 9.25%, 18.51%, 16.66%, 18.51%, 20.3%, and 16.66% in the control group, CIP-group, FOS-group, COT-group, Gent-group, and ESBL groups, respectively. Of the total isolates that produced biofilm ( n = 51), 11.76% of isolates showed biofilm formation in the control group. Alternatively, the rate was found to be 15.68%, 11.76%, 25.49%, 19.6%, and 15.68% in the CIP-group, FOS-group, SXT-group, Gen-group, and ESBL-groups, respectively. Conclusion This study correlates the association between phenotypic characteristics, antimicrobial resistance, and biofilm production, the three main characteristics of C. freundii.
Clinical audit of the Consultation-Liaison psychiatric service of a metropolitan hospital
Authors: Sharma Dr Varun Gautam , Gonzalez Dr Andres Eduardo Martinez 
Published: January 2023

Objective The primary objective of this study was to use clinical indicators to track changes in efficiency of a Consultation-Liaison service as part of a clinical audit cycle. Methods This was a clinical audit cycle. The auditing phase involved measuring the efficiency of the service. The ‘intervention’ was simply the team’s awareness and involvement in tracking these statistics. Subsequently, these indicators were re-audited. Results In the initial audit cycle, 315 referrals to the C-L service were audited over a 3 month period, showing a 24 hour time-to-seen rate of 80% and a 36 hour time-to-seen rate of 89.2%. Upon re-auditing of 112 referrals following our intervention, 24 hr timeliness had risen to 92% and 36 hr timeliness had risen to 96.4%. Conclusion The measuring of clinical indicators of efficiency in C-L may give service improvement personnel a reflection of the functionality of a C-L service. By involving team members in the measuring and tracking of these indicators, we may be able to boost overall clinical efficiency and outcomes.
Acquired Hemophilia A: A Retrospective Multicenter Analysis of 42 Patients
Authors: Liu Yanhui , Ruan Xiang , Lei Pingchong , Shang Baojun , Zhu Zunmin , Chen Shengmei , Wang Dao , Wang Ruijuan , Li Xiqing , Xue Fei 
Published: January 2023

Introduction Immunosuppressive therapy (IST) for acquired hemophilia A (AHA) results in remission within days to months in 60% to 80% of patients. However, little is known regarding the predictors of response. Aim This study aimed to identify the factors that influence response to treatment. Methods The data of 42 patients with AHA from three hospitals were retrospectively analyzed. Results All 42 AHA patients received IST; complete treatment data were available for 34 patients. The response rate was 60% among the 5/34 (14.7%) patients who received steroids alone, 70.8% among the 24/34 (70.6%) patients who received steroids plus cyclophosphamide, and 80% among the 5/34 (14.7%) patients who received steroids plus cyclophosphamide and rituximab. Overall, 29/34 (85.3%) patients achieved CR; 4/34 (13.8%) of them relapsed after a median time of 410 (21–1279) days. Adverse events occurred in 14/34 (41.2%) patients: 13/34 (38.2%) had infections and 1/34 (2.9%) developed pancytopenia. In univariate and multivariate Cox regression analyses, FVIII inhibitor titer ≥20 BU/mL was the only significant prognostic factor affecting time to CR. No variable had significant effect on OS. Conclusion FVIII inhibitory antibody titer ≥20 BU/mL appears to be an important predictor of time to complete response in patients with acquired hemophilia A treated with immunosuppressive therapy.
Family health conditions and parental occupational status modify the relationship between pediatric-onset multiple sclerosis and parental health-related quality of life
Authors: O’Mahony Julia , Banwell Brenda , Laporte Audrey , Brown Adalsteinn , Bolongaita Lady , Bar-Or Amit , Yeh E Ann , Marrie Ruth Ann 
Published: January 2023

Background: The health-related quality of life (HRQoL) of children with multiple sclerosis (MS) is mediated by the HRQoL of their parents. Understanding factors that modify the relationship between the child’s MS diagnosis and parental HRQoL would inform interventions to improve the HRQoL of both parents and children living with MS. Objective: We evaluated whether the association between an MS diagnosis during childhood and parental HRQoL is modified by the presence of a family health condition or low socioeconomic position (SEP). Methods: Parents of children with MS or the transient illness, monophasic-acquired demyelinating syndromes (monoADS), were enrolled in a prospective Canadian study. Multivariable models evaluated whether the association between a child’s MS diagnosis (vs. monoADS) and parental HRQoL was modified by ⩾1 family health conditions or low SEP. Results: Two hundred seven parents and their children with MS ( n = 65) or monoADS ( n = 142) were included. We found a synergistic effect of an MS diagnosis and a family health condition on parental HRQoL. We also found a synergistic effect of having MS and a low SEP on parental HRQoL. Conclusion: Parents of children with MS who have another family health condition or a low SEP are at particularly high risk for low HRQoL.
iSupport-Brasil: Cross-cultural adaptation of the content included in the iSupport program for caregivers of people who have dementia
Authors: Monteiro Diana Q. , Ottaviani Ana C. , Campos Camila R. F. , Barham Elizabeth J. , Oliveira Déborah , da Cruz Keila C. T. , Pavarini Sofia C. I. , de Souza Orlandi Fabiana , Zazzetta Marisa S. , Jacinto Alessandro F. , Corrêa Larissa , Gratão Aline C. M. 
Published: January 2023

Objective Examine the process of culturally adapting the content of the World Health Organization iSupport program for family caregivers of people living with dementia in Brazil. Method This is a multicenter and methodological study to cross-culturally adapt the iSupport program. Initially, the content of the iSupport program was translated into Brazilian Portuguese by professional translator trained in Psychology, with mastery of the original language of the content (English). Focus groups were then held with caregivers/former caregivers of people who have dementia ( n = 24) and health professionals specialized in aging ( n = 24). The participants had access to part of the iSupport material for analysis purposes. Semi-structured interviews were conducted between June and September 2019. All the interviews were recorded and transcribed in full for subsequent analysis. All the ethical aspects were respected. Results The translator implemented some cross-cultural adaptations, such as substituting 69 proper names used in the original version by names of different Brazilian regions. In relation to the analysis of the material and comments from the focus groups, in general, all the participants had positive opinions about the material included in iSupport. Some changes were suggested in relation to the terminology and examples given in the modules to better fit the Brazilian culture and health systems, and links to relevant pages of the local Alzheimer’s association were included. All the linguistic and cultural adaptations proposed were systematically documented and duly justified in structured forms provided by the World Health Organization, which approved all of them after verification of fidelity. Conclusion The product of this research is the first version of the iSupport-Brasil program and the inclusion of its content in a digital platform. For the most part, the content offered in iSupport proved to be an important online tool to provide support and diverse information to the caregivers of people who have dementia.
Tenecteplase versus alteplase for stroke thrombolysis evaluation (TASTE): A multicentre, prospective, randomized, open-label, blinded-endpoint, controlled phase III non-inferiority trial protocol
Authors: Bivard Andrew , Garcia-Esperon Carlos , Churilov Leonid , Spratt Neil , Russell Michelle , Campbell Bruce CV , Choi Philip , Kleinig Timothy , Ma Henry , Markus Hugh , Molina Carlos , Hsu Chung , Tsai Chon-Haw , Meretoja Atte , Strbian Daniel , Butcher Kenneth , Wu Teddy , Davis Stephen , Donnan Geoffrey , Levi Christopher , Parsons Mark 
Published: January 2023

Rationale: Alteplase is the only approved thrombolytic agent for acute stroke. An alternative plasminogen activator, tenecteplase, has been previously shown to increase early biological effectiveness (reperfusion) resulting in early clinical recovery in acute stroke patients with target mismatch on perfusion imaging; however, phase III data are lacking. Aim and hypothesis: In this study, we assess the efficacy and safety of tenecteplase compared to alteplase in acute stroke patients with target mismatch on perfusion imaging. Methods and Design: Tenecteplase (0.25 mg/kg) versus alteplase (0.9 mg/kg) for Stroke Thrombolysis Evaluation (TASTE) is a multicentre, prospective, randomized, open-label, blinded-endpoint (PROBE), controlled phase III non-inferiority trial (2 arms with 1:1 randomization) with an adaptive sample size re-estimation in patients with acute ischemic stroke meeting target mismatch criteria on perfusion imaging. Sample size estimates: Recruiting 728 patients (1:1 tenecteplase vs alteplase) would yield 90% power (two-sided alpha 0.05) to detect a treatment effect of 8% (26% modified Rankin scale (mRS) 0–1 in alteplase arm and 34% mRS 0–1 in tenecteplase arm), with an absolute non-inferiority margin of 3%. Following the pre-planned “promising zone” adaptive sample size re-estimation, the final sample size was set at 832 patients. Study outcomes: The primary outcome measure is the proportion of patients with an mRS score of 0–1 at 3 months. Secondary outcomes include the categorical shift in mRS at 3 months; the proportion of patients with: mRS 0–2, 5–6, and 6; reduction of the National Institutes of Health Stroke Scale (NIHSS) by 8 or more points or reaching 0–1 at 24 h; symptomatic intracerebral hemorrhage within 36 h; and death. Discussion: This pivotal trial will provide important data on the role of tenecteplase in acute ischemic stroke, and the use of imaging-based treatment decision-making for stroke thrombolysis. Clinical trial protocol: Trial Registration: ACTRN12613000243718, EudraCT 2015-002657-36