bluuebunny/crossref_metadata_2025_split huggingface dataset:
Oritavancin as Sequential Therapy for Gram-positive Bloodstream Infections
Authors: Texidor Williams Monier , Miller Matthew A. , Molina Kyle C. , Krsak Martin , Calvert Barbara , Hart Caitlin , Storer Marie , Fish Douglas N. 
Published: July 2023

Abstract
Background
Oritavancin, a long-acting lipoglycopeptide approved for use in acute bacterial skin and skin structure infections, has limited data evaluating use in serious infections due to Gram-positive organisms. We aimed to assess the effectiveness and safety of oritavancin for consolidative treatment of Gram-positive bloodstream infections (BSI), including infective endocarditis (IE).
Methods
We conducted a retrospective cohort evaluating adult patients admitted to University of Colorado Hospital from March 2016 to January 2022 who received ≥ 1 oritavancin dose for treatment of Gram-positive BSI. Patients were excluded if the index culture was drawn at an outside facility or were > 89 years of age. The primary outcome was a 90-day composite failure (clinical or microbiological failure) in those with 90-day follow-up. Secondary outcomes included individual components of the primary outcome, acute kidney injury (AKI), infusion-related reactions (IRR), and institutional cost avoidance.
Results
Overall, 72 patients were included. Mean ± SD age was 54 ± 16 years, 61% were male, and 10% had IE. Organisms most commonly causing BSI were Staphylococcus aureus (68%, 17% methicillin-resistant), followed by Streptococcus spp. (26%), and Enterococcus spp. (10%). Patients received standard-of-care antibiotics before oritavancin for a median (IQR) of 11 (5–17) days. Composite failure in the clinically evaluable population (n = 64) at 90-days occurred in 14% and was composed of clinical and microbiological failure, which occurred in 14% and 5% of patients, respectively. Three patients (4%) experienced AKI after oritavancin, and two (3%) experienced an IRR. Oritavancin utilization resulted in earlier discharge for 94% of patients corresponding to an institutional cost-avoidance of $3,055,804 (mean $44,938/patient) from 1,102 hospital days saved (mean 16 days/patient).
Conclusions
The use of oritavancin may be an effective sequential therapy for Gram-positive BSI to facilitate early discharge resulting in institutional cost avoidance.
Prevalence and Risk Factors of Obesity among Undergraduate Student Population in Ghana: An Evaluation Study of Body Composition Indices
Authors: Obirikorang Christian , Adu Evans Asamoah , Anto Enoch Odame , Awuah Anthony Afum-Adjei , Fynn Angela Nana Bosowah , Osei-Somuah George , Ansong Patience Nyarkoa , Boakye Alexander Owusu , Boadu Ivy Ofori , Obirikorang Yaa , Adobasom-Anane Austin Gideon , Nyarko Eric NY , Balmer Lois 
Published: July 2023

Abstract
Background
Obesity is a classified risk factor for several of the world’s leading causes of death. In this study, we combined information contained in body mass index (BMI), total percentage body fat (TPBF) and relative fat mass (RFM) to estimate obesity prevalence.
Methods
The study recruited 1027 undergraduate students aged between 16–25 years using a cross-sectional study design and two-stage stratified random sampling. Demographic, lifestyle, and family history of chronic disease data, were collected using a structured questionnaire. Bioelectrical impedance, along with height, weight, age, and gender, was used to estimate BMI and TPBF. RFM was calculated using a published equation. TPBF and RFM ranges were evaluated based on standard BMI thresholds and an informative combined obesity prevalence estimated in a Bayesian framework. Multiple logistic regression analysis was used to evaluate risk factors.
Results
Concordance between BMI, TPBF and RFM for obesity classification was 84% among female and 82.9% among male students. The Bayesian analysis revealed a combined prevalence means of obesity of 9.4% (95%CI: 6.9%-12.2%) among female students and 6.7% (95%CI:4.3%-9.5%) among male students. The odds of obesity were increased between 1.8 and 2.5 for females depending on the classification index. A significant increasing trend of obesity was observed with university-level. A family history of obesity was associated with a high estimate of general, central, and high TPBF.
Conclusion
Using multiple adiposity indicators conjointly in a Bayesian framework offers a greater power to examine obesity prevalence. We have applied this and reported high obesity prevalence, especially among female students. University level and family history of obesity were key determinants for obesity among the student population.
Dynamics, stability and bifurcations of a planar three-link swimmer with passive visco-elastic joint using “ideal fluid” model
Authors: Tovi Elon , Zigelman Anna , Or Yizhar 
Published: July 2023

Abstract
Articulated swimming robots have a promising potential for various marine applications. A common theoretical model assumes ideal fluid, where the viscosity is negligible and the swimmer-fluid interaction is induced by reactive forces originating from added mass effect. Some previous works used this model to study planar multi-link swimmers under kinematic input prescribing all joint angles. Inspired by biological swimmers in nature that utilize body flexibility, in this work we consider an underactuated three-link swimmer where one joint is periodically actuated while the other joint is passive and viscoelastic. Analysis of the swimmer’s nonlinear dynamics reveals that its motion depends significantly on the amplitude and frequency of the actuated joint angle. Optimal frequency is found where the swimmer’s net displacement per cycle is maximized, under symmetric periodic oscillations of the passive joint. In addition, upon crossing critical values of amplitude or frequency, the system undergoes a bifurcation where the symmetric periodic solution loses stability and asymmetric solutions evolve, for which the swimmer moves along an arc. We analyze these phenomena using numerical simulations and analytical methods of perturbation expansion, harmonic balance, Floquet theory and Hill’s determinant. The results demonstrate the important role of parametric excitation in stability and bifurcations of motion for flexible underactuated locomotion.
The Role of Probiotic in Psoriasis Treatment: A Meta-Analysis of Randomized Controlled Clinical Trials
Authors: Umborowati Menul Ayu , Rosita Primadita Esther , Endaryanto Anang , Surono Ingrid S , Thio Hok Bing , Prakoeswa Cita Rosita Sigit 
Published: July 2023

Abstract
Backgrounds: The body of knowledge about the pathogenesis and treatment of psoriasis is expanding. Several recent studies have suggested a link between dysbiosis in the gut microbiome and the occurrence of psoriasis. Probiotics are thought to treat gut microbiome dysbiosis.
Methods: The literature included randomized control trials (RCT) studies published between January 2003 and June 2022 and found in three databases. Review Manager 5.4 software was used for statistical analysis.
Results:This meta-analysis study included 4 RCT articles involving 212 adults. This study’s RCTs all compared oral probiotics to a placebo. For the clinical improvement outcome, this study showed that the probiotic group had 1.82 times higher risk of recovery than the placebo group (P < 0.05). C-reactive Protein levels were found to be 1.25 times lower in patients who received probiotic supplementation (P < 0.05). Meanwhile, a study on Interleukin 6 (IL-6) levels found that probiotic supplementation reduced serum IL-6 levels by 1.28 times, but this was not statistically significant (P= 0.35).
Conclusion: Oral probiotic supplementation may be beneficial for psoriasis treatment because it reduces clinical severity and inflammation.
On vulnerabilities in EVT-based timing analysis: an experimental investigation on a multi-more architecture
Authors: Vasconcelos Jamile , Lima George , Khazen Marwan Wehaiba El , Gogonel Adriana , Cucu-Grosjean Liliana 
Published: July 2023

Abstract
Hardware architectures equipped with multiple cores, cache memory and branch prediction usually preclude the application of classical methods for determining execution time bounds for real-time tasks. As such bounds are fundamental in the designing of real-time systems, Measurement-Based Probabilistic Timing Analysis (MBPTA) has been employed. A common choice is the derivation of probabilistic Worst-Case Execution Time (pWCET) via the use of Extreme Value Theory (EVT), a branch of statistics used to estimate the probability of rare events that are more extreme than observations. However, pWCET estimations are usually reported in a controlled or simulated environment. In this paper we apply MBPTA in a real multi-core platform, namely Raspberry Pi 3B, taking into consideration possible interference due to operating system and concurrent activities. The results indicate that although EVT is effective, it does not always produce adequate models and coherent pWCET estimations. As MBPTA is primarily called for when classical methods are not applicable, as it is the case for the studied platform, the results reported in this paper highlight risks and vulnerabilities when applying MBPTA-EVT for pWCET inference.
WITHDRAWN: Environmental Kuznets Curve and Roles of Development Finance in the Global South
Authors: Wang Yan , Xu Yinyin 
Published: July 2023

Abstract
This study investigates the nexus between CO2 emissions, economic development and development finance using a novel dataset for 76 developing countries from 1995 to 2018. Employing a framework of three dimensions, the natural endowment, the real economy and the financial sector, our estimation method takes into account the bi-directional causality of the environmental delegation and economic growth by adopting the simultaneous equations model estimated via fixed effect 2SLS. In the tradition of the environment Kuznets curves (EKC), we found an inverted N-shaped EKC relationship in the panel data which is statistically significant and robust. On development finance, net transfers from bilateral and multilateral banks are not directly associated with environmental degradation. The green natural capital is negatively and statistically significantly associated with the CO2 emissions density, providing some evidence for the existence of the “biological carbon sequestration” effect. Our results provide insights to enhance the effectiveness of future development finance, e.g. to renewable energy, investment in human capital and green natural capital.
Haze prediction research based on PSO-CPU-GPU heterogeneous parallel support vector regression machine
Authors: Liu Zuhan , Zhao Kexin , Liu Xuehu , Xu Huan 
Published: July 2023

Abstract
Human life and development are affected by air quality, which means it is significant to accurately estimate air quality utilizing science. Considering PM2.5 is an essential component of air pollution, accurate PM2.5 prediction is crucial to maintaining air quality, preserving human wellness, and advancing urbanization's sustainability and scientific evolution. In this investigation, we provide a Particle Swarm Optimization (PSO) and Central Processing Unit-Graphics Processing Unit (CPU-GPU) heterogeneous parallel Support vector regression (SVR) method to forecast the airborne PM2.5 content. The approach enhances computational effectiveness, accelerates solution times, and satisfies debugging and application requirements in realistic circumstances where the size and dimensionality of the pertinent data are increasing. by contrasting it with conventional support vector regression methods and conducting analysis of variance on various data sets. The simulation results demonstrate a rise of over fifty per cent in prediction speed with a high degree of accuracy for the CPU-GPU heterogeneous parallel support vector regression (PSO-CPU-GPU-SVR) model.
Three-Dimensional Reconstruction of Ribs Based on Point Cloud Adaptive Smoothing Denoising
Authors: He Bishi , Wang Diao , Chen Yuanjiao , Xu Zhe , Zhu Darong 
Published: July 2023

Abstract
The traditional methods for 3D reconstruction mainly involve using image processing techniques or deep learning segmentation models for rib extraction. After post-processing, voxel-based rib reconstruction is achieved. However, these methods suffer from limited reconstruction accuracy and low computational efficiency. To overcome these limitations, this paper proposes a rib 3D reconstruction method based on point cloud adaptive smoothing and denoising. We convert the voxel data from the CT images to multi-attribute point cloud data. Then, we apply point cloud adaptive smoothing and denoising methods to eliminate noise and non-rib points in the point cloud. Additionally, efficient 3D reconstruction and post-processing techniques are employed to achieve high-accuracy and comprehensive rib 3D reconstruction results. Experimental calculations demonstrate that compared to voxel-based rib 3D reconstruction methods, the rib 3D models generated by the proposed method achieve a 40% improvement in reconstruction accuracy and are twice as efficient as the former.
Responses of Earthworms to Acetamiprid
Authors: Erhunmwunse Nosakhare Osazee , Tongo Isioma , Endurance Ewere E , Ogbeide Ozekeke . S. , Oruma Benedicta , Omniabios Christopher , Ikeh Rupert 
Published: July 2023

Abstract
To increase agricultural output, millions of tonnes of neonicotinoids are reportedly used worldwide, but these agrochemicals have negative impacts on soil quality and biodiversity. 98% of pesticides applied reach non-target organisms in the water and soil including the earthworms. Earthworm provides significant contributions to soil fertility and serves as a bioindicator for pesticide-induced soil pollution in an ecotoxicological investigation. In this study, earthworms (Aporrectodea longa) were subjected to commercial-grade Acetaminprid at various doses for 14 days and the LC50 was found to be 2.52 mg/kg. Morphological alterations and behavioral changes such as weight loss, avoidance, and growth rate were observed to be concentration-dependent. Catalase (CAT), glutathione-S-transferase (GST), glutathione peroxidase (GPx), C-reactive protein (CRP), and Total Oxidative Capacity (TAC) activities were also measured. Significant alterations in these stress markers were detected in pesticide-exposed earthworms at increasing pesticide concentrations. Our findings showed that the exposed earthworm's growth rate decreased, its digging activity slowed down, it died, and it lost a significant amount of weight. These findings varied significantly depending on the pesticide concentration. This study indicates that Earthworms are particularly susceptible to acetamiprid, which cause immobility and rigidity, as well as a reduction of biomass and growth by disturbing numerous physiological activities, resulting in a loss of the earthworm population.
MiR-2110 induced by chemically synthesized cinobufagin functions as a tumor-metastatic suppressor via targeting FGFR1 to reduce PTEN ubiquitination degradation in nasopharyngeal carcinoma
Authors: Fang Shiyi , Hou Rentao , Zhang Mengmin , Deng Xing , Li Xiaoning , Xin Jianyang , Peng Lingrong , Liu Zhihua , Liu Yiyi , Xie Yingying , Fang Weiyi , Cheng Chao , Liu Zhen 
Published: July 2023

Abstract

Tumor cell metastasis is the key cause of death in patients with nasopharyngeal carcinoma(NPC). MiR-2110 was cloned and identified in Epstein-Barr virus (EBV)-positive NPC, but its role is unclear in NPC. In this study, we investigated the effect of miR-2110 on NPC metastasis and its related molecular basis. In addition, we also explored whether miR-2110 can be regulated by Cinobufotalin(CB) and participate in the inhibition of CB on NPC metastasis. Bioinformatics, RT-PCR, and In situ hybridization were used to observe the expression of miR-2110 in NPC tissues and cells. Scratch, boyden and tail vein metastasis model of nude mouse were used to detect the effect of miR-2110 on NPC metastasis. Western blot, CoIP, luciferase activity, co-localization of micro confocal and ubiquitination assays were used to identify the molecular mechanism of miR-2110 affecting NPC metastasis. Finally, miR-2110 induced by CB participates in CB-stimulated inhibition of NPC metastasis was explored. Increased miR-2110 significantly suppressed NPC cell migration, invasion, and metastasis. Suppressing miR-2110 markedly restored NPC cell migration and invasion. Mechanistically, miR-2110 directly targeted FGFR1 and reduced its protein expression. Decreased FGFR1 attenuated its recruitment of NEDD4, which downregulated NEDD4-induced PTEN ubiquitination degradation and increased PTEN protein stability, thereby inactivating PI3K/AKT-stimulated EMT signaling and ultimately suppressing NPC metastasis. Interestingly, cinobufagin (CB), a potential new inhibitory drug for NPC metastasis, significantly induced miR-2110 expression by suppressing PI3K/AKT/c-Jun-mediated transcription inhibition. Suppression of miR-2110 significantly restored cell migration and invasion in CB-treated NPC cells. Finally, a clinical sample assay indicated that reduced miR-2110 was negatively correlated with NPC lymph node metastasis and positively related to NPC patient survival. In summary, miR-2110 is a metastatic suppressor that is involved in CB-induced suppression of NPC metastasis.
Online Caching Algorithm for VR Video Streaming in Mobile Edge Caching System
Authors: Liu Qiuming , Chen Hao , Li Zihui , Bai Yaxin , Wu Dong , Zhou Yang 
Published: July 2023

Abstract
The transmission optimization of VR video streaming can improve the quality of user experience, which includes content prediction optimization and caching strategy optimization. Existing work either focuses on content prediction or on caching strategy. However, in the end-edge-cloud system, prediction and caching should be considered together. In this paper, we jointly optimize the four stages of prediction, caching, computing and transmission in mobile edge caching system, aimed to maximize the user's quality of experience. In terms of caching strategy, we design a caching algorithm VIE with unknown future request content, which can efficiently improve the content hit rate, as well as the durations for prediction, computing and transmission. The VIE caching algorithm is proved to be ahead of other algorithms in terms of delay. We optimize the four stages under arbitrary resource allocation and simulate the proposed caching algorithm according to the degree of overlap, as well as completion rate. Finally, under the real scenario, the proposed caching algorithm is verified by comparing with several other caching algorithms, simulation results show that the user's QoE is improved under the proposed caching algorithm.
Division mechanism of labor in Diqing Tibetan Pigs gut microbiota for dietary fiber efficiently utilization
Authors: Yang Lijie , Yao Bingqian , Zhang Shimin , Yang Yuting , Wang Gang , Zhou Junyan , Ye Changchuan , Pan Hongbin , Zeng Xiangfang , Qiao Shiyan 
Published: July 2023

Abstract
Background
The Diqing Tibetan (DT) pig is an herbivorous breed that inhabits an area with the highest altitude distribution in the world and can be maintained on a diet containing 90% forage material in confinement production systems. The possible association between specialized gut microorganisms and the efficient utilization of dietary fiber in this breed are unclear.
Results
Digestibility analysis showed that DT pigs had a strong capability for high-efficiency utilization of arabinose and xylose. Microorganisms in the cecum preferred to use xylan and uronic acid, while colonic microorganisms were better at using cellulose, glucan and mannan. Metagenomic analysis revealed that the high expression of feruloyl esterase, endo-β-1,4-xylanase, β-1,3-D-glucosidase, β-mannosidase, β-1,3(4)-glucanase and reducing-end xylanase in the intestinal microorganisms of these pigs was a decisive factor for the efficient utilization of nonstarch polysaccharides. The secretion of carbohydrate esterases was mainly undertaken by fecal strains of Microbacterium, Alistipes, Acinetobacter, and Faecalibacterium, while Microbacterium, Prevotella, Turicibacter, Lactobacillus, Clostridium and Streptococcus were responsible for most of the secretion of glycoside hydrolases. Then, a new species of Microbacterium was captured and appeared to have the highest fiber utilization ability in vitro, degrading 36.54% of the neutral detergent fiber in corn stover. The results of whole genome sequencing showed that the 16S rRNA sequence similarity between the strain and the microorganisms in the database was less than 97.113%, and the average nucleotide identity (ANI) was less than 95%. The strain was finally determined to be a brand new species, which was named Microbacterium sp. Qiao 01. Then, a total of 161 carbohydrate enzyme genes were annotated, including 80 glycoside hydrolases, 40 glycosyltransferases, 26 carbohydrate esterases, 11 auxiliary oxidoreductase, 3 polysaccharide lyases and 1 carbohydrate domain.
Conclusions
Our results provide strong evidence that efficient utilization of dietary fiber by DT pigs is due to the emergence of highly specialized microbial strategies in the gut. Microorganisms showed preferences and a clear division of labor in the degradation process of dietary fiber. Microbacterium sp. Qiao 01 was the key player in the efficient utilization of nonstarch polysaccharides in DT pigs. This study may inspire novel approaches for the deep excavation of high-quality microbial resources in regional species and has great practical significance for improving the utilization efficiency of livestock feed and alleviating the tension of food insecurity.