bluuebunny/crossref_metadata_2025_split huggingface dataset:
Updated normative data for the EORTC QLQ-C30 in the general Dutch population by age and sex: a cross-sectional panel research study
Authors: de Ligt K. M. , Aaronson N. K. , Liegl G. , Nolte S. ,   the EORTC Quality of Life Group
Published: April 2023

Abstract
Purpose
The European Organisation for Research and Treatment of Cancer (EORTC) quality of life core questionnaire (QLQ-C30) is a validated and widely-used Patient-Reported Outcome Measure for measuring the health-related quality of life (HRQoL) of cancer patients. To facilitate interpretation of results obtained in studies using the EORTC QLQ-C30, we generated normative data for the Dutch general population, stratified by age and sex.

Methods
Dutch participants were selected from a larger cross-sectional online panel research study collecting EORTC QLQ-C30 general population normative data across 15 countries. EORTC QLQ-C30 raw scores based on a 4-point response scale were transformed to linear scores ranging from 0 to 100. Transformed scores were weighted based on the United Nations population distribution statistics and presented by age and sex/age. Differences in scale scores of ≥ 10 points in HRQoL were applied to indicate clinical relevance.

Results
One thousand respondents completed the online survey. Stratified by age, clinically meaningful differences were observed, with worse physical functioning scores and better emotional functioning scores with increased age. Symptom scores remained stable across age groups, except for small age differences observed for fatigue, nausea/vomiting, diarrhoea, and financial difficulties. Stratified by sex/age, men generally scored better for both functioning and symptoms. However, these differences were not clinically meaningful.

Conclusions
These updated normative EORTC QLQ-C30 for the Dutch general population can be used to better interpret HRQoL data obtained from Dutch cancer patients. Being part of a larger international study, these data can further be used for inter-country comparisons in multi-national studies.
A traceable and revocable multi-authority attribute-based access control scheme for mineral industry data secure storage in blockchain
Authors: Zhang Xiaohong , Du Wenqi , Moshayedi Ata Jahangir 
Published: April 2023

AbstractWith the rapid advancements of the mineral industry, the data generated by this industry chain have increased dramatically. To reduce the growing pressure of data storage and security risks, we design a credible on-chain and off-chain collaborative dual storage system that integrates blockchain technology and Interplanetary file system (IPFS), also construct a traceable and revocable multi-authority ciphertext-policy attributed-based encryption (CP-ABE) algorithm to meet the demand of privacy protection and dynamic fine-grained access control. Furthermore, the multi-authority layered authorization with a central authority model distributes system overhead while enabling the platform can be regulated. More importantly, our scheme achieves accurate trace of the malicious users by white-box traceability and capable of implementing indirect immediate user and attribute revocation without requiring key or ciphertext updates. Finally, the proposed scheme is indistinguishably secure under chosen-plaintext attack (IND-CPA) in the standard model. And the performance analysis demonstrates that our scheme is feature-rich, practical and efficient.
Wear Reduction via CNT Coatings in Electrical Contacts Subjected to Fretting
Authors: Alderete Bruno , Mücklich Frank , Suarez Sebastian 
Published: April 2023

AbstractCarbon nanotubes (CNT) are of great interest to the research community due to their outstanding mechanical, transport, and optical properties. These nanoparticles have also shown exceptional lubricating capabilities, which coupled with their electrical conductivity show promising results as solid lubricants in electrical contacts. In this study, three different CNT coatings were deposited over copper platelets via electrophoretic deposition and subsequently tribo-electrically characterized including electrical contact resistance evolution during fretting wear, wear protection, chemical analysis of fretting marks, as well as influence of CNT coating thickness, duration and normal load applied during fretting, and atmospheric humidity. Thicker CNT coatings show improved wear protection while retaining similar electrical behavior as uncoated copper, or even improving its electrical contact resistance. Moreover, the compaction of the porous CNT coating is crucial for optimal electrical performance at low humidity. For longer fretting tests (150,000 and 500,000 cycles), the coatings are displaced thus affecting the wear protection offered. However, the coatings stabilize and reduce ECR compared to uncoated samples. Furthermore, thicker CNT coatings can bear higher loads during fretting due to the increased lubricant reservoir, with carbonaceous tribofilm remaining at the contacting interface after 5,000 fretting cycles regardless of normal load.
Graphical Abstract
Monitoring of age- and gender-related alterations of endocannabinoid levels in selected brain regions with the use of SPME probes
Authors: Roszkowska Anna , Klejbor Ilona , Bogusiewicz Joanna , Plenis Alina , Bojko Barbara , Kowalik Katarzyna , Moryś Janusz , Bączek Tomasz 
Published: April 2023

Abstract
Introduction
The endocannabinoid system consists of different types of receptors, enzymes and endocannabinoids (ECs), which are involved in several physiological processes, but also play important role in the development and progression of central nervous system disorders.

Objectives
The purpose of this study was to apply precise and sensitive methodology for monitoring of four ECs, namely anandamide (AEA), 2-arachidonoyl glycerol (2-AG), N-arachidonoyl dopamine (NADA), 2-arachidonyl glyceryl ether (2-AGe) in selected brain regions of female and male rats at different stages of development (young, adult and old).

Methods
Biocompatible solid-phase microextraction (SPME) probes were introduced into the intact (non-homogenized) brain structures for isolation of four ECs, and the extracts were subjected to LC–MS/MS analysis. Two chemometric approaches, namely hierarchical cluster analysis (HCA) and Principal Component Analysis (PCA) were applied to provide more information about the levels of 2-AG and AEA in different brain structures.

Results
2-AG and AEA were extracted and could be quantified in each brain region; the level of 2-AG was significantly higher in comparison to the level of AEA. Two highly unstable ECs, NADA and 2-AGe, were captured by SPME probes from intact brain samples for the first time.

Conclusion
SPME probes were able to isolate highly unstable endogenous compounds from intact tissue, and provided new tools for precise analysis of the level and distribution of ECs in different brain regions. Monitoring of ECs in brain samples is important not only in physiological conditions, but also may contribute to better understanding of the functioning of the endocannabinoid system in various disorders.
Kant’s Formula of Autonomy: Continuity or Discontinuity?
Authors: Kleingeld Pauline 
Published: April 2023

AbstractIn two recent articles I have argued that Kant’s legal and political philosophy can shed new light on his much-contested account of moral autonomy and that important changes in his political theory help to explain why in his later work the Formula of Autonomy disappears. In the present essay, I respond to comments by Sorin Baiasu and Marie Newhouse, who argue that the changes in Kant’s political theory fail to explain the disappearance of the Formula of Autonomy, since in both phases Kant held that laws are given by the people’s representatives. I offer additional support for my original argument by developing a more detailed account of Kant’s conception of the relation between the legislating representatives and the people they are taken to represent. I argue that Kant’s conception of the proper representation relation changed, and that it changed so fundamentally that the analogy at the basis of the Formula of Autonomy was no longer apt, thus providing a plausible explanation for its disappearance. I also address several related comments and propose an explanation for why Kant dropped the very idea of autonomy as a property of the will.
Potato Ethics: What Rural Communities Can Teach Us about Healthcare
Authors: Fors Malin 
Published: April 2023

AbstractIn this paper I offer the term “potato ethics” to describe a particular professional rural health sensibility. I contrast this attitude with the sensibility behind urban professional ethics, which often focus on the narrow doctor–patient treatment relationship. The phrase appropriates a Swedish metaphor, the image of the potato as a humble side dish: plain, useful, versatile, and compatible with any main course. Potato ethics involves making oneself useful, being pragmatic, choosing to be like an invisible elf who prevents discontinuity rather than a more visible observer of formal rules and assigned tasks. It also includes actively taking part in everyday disaster-prevention and fully recognizing the rural context as a vulnerable space. This intersectional argument, which emphasizes the ongoing, holistic responsibility of those involved in rural communities, draws on work from the domains of care ethics, relational ethics, pragmatic psychology, feminist ethics of embodiment, social location theory, and reflections on geographical narcissism.
Proper biharmonic maps and $$(2,1)$$-harmonic morphisms from some wild geometries
Authors: Ghandour Elsa , Gudmundsson Sigmundur 
Published: April 2023

AbstractIn this work we construct a variety of new complex-valued proper biharmonic maps and (2, 1)-harmonic morphisms on Riemannian manifolds with non-trivial geometry. These are solutions to a non-linear system of partial differential equations depending on the geometric data of the manifolds involved.
Epoxy-Silicon Composite Materials from End-of-Life Photovoltaic Panels
Authors: Pavlopoulos C. , Christoula A. , Patsidis A. C. , Semitekolos D. , Papadopoulou K. , Psarras G. C. , Zoumpoulakis L. , Lyberatos G. 
Published: April 2023

AbstractThe prospect of using recovered solar cells from end-of-life (EoL) photovoltaic panels (PVPs) to produce composite materials with dielectric properties was studied. The main goal of this research was to reduce the waste originating from EoL PVPs by reusing the semiconductor, thus rendering solar energy an even greener energy source. Solar cells were recovered from EoL PVPs through thermal treatment to remove polymer sheets and screening to separate the solar cells from glass and electrodes. Composite materials were manufactured by reinforcing two different epoxy resins, Araldite LY556 and Resoltech 1050, with varying concentrations of ground solar cells (0–10% w/w). The mechanical and dielectric properties of the composite materials were examined with bending and shearing tests and Broadband Dielectric Spectroscopy (BDS), respectively. The responses from the two different resin matrices were compared. It was found that the produced composite material resulting from Resoltech resin reinforced with solar cells recovered from EoL PVPs had better mechanical and dielectric properties. BDS characterization of the composite materials indicated that the solar cells can be used to enhance the energy storage capacity of the polymeric matrix and thus may be potentially used in the manufacturing of capacitors.
Graphical Abstract
Seasonal shift in the diet of the notched-eared bat (Myotis emarginatus) in the Basque Country: from flies to spiders
Authors: Vallejo Nerea , Aihartza Joxerra , Olasagasti Lander , Aldasoro Miren , Goiti Urtzi , Garin Inazio 
Published: April 2023

AbstractMyotis emarginatusseems fond of spiders and flies, a unique feeding style among European bats. The importance of each prey type varies among studies, so this paper aims to expand on the knowledge to unveil the trophic niche ofM. emarginatusby studying its diet changes throughout the maternity season. We sampled five maternity colonies in the Basque Country every 2 weeks for the whole duration of the maternity season and studied their diet using DNA metabarcoding methods. We observed significant changes in diet diversity and composition. At the beginning of the season,M. emarginatusconsumed a variety of prey orders, Diptera being the most abundant; but as the season progressed, the relative consumption of Araneae increased. By August, 80% of the weighted percentage of occurrences (wPOO) corresponded to the orb-web-building spiderAraneus diadematus. Orb-web-building spiders need habitats of high vertical complexity to grow in abundance. Therefore, conserving them is essential to preserve attractive hunting grounds for colonies ofM. emarginatus. Besides, diurnal flies, mainlyStomoxys calcitrans, were also considerably consumed in the colonies studied, which can become detrimental to the well-being of cattle, and can act as a vector of many diseases.
Parathyroid adenoma mimicking bethesda class III follicular thyroidal lesion: A case report
Authors: Peterson Caspar J. , Klasen Jennifer M. , Bubendorf Lukas , Freitag Martin , Delko Tarik , Lazaridis Ioannis I. 
Published: April 2023

Abstract

Introduction and importance
Although the majority of thyroid lesions are benign, diagnostic workup including fine needle aspiration biopsy cytology is important to rule out cancerous lesions. However, cytological findings may pose challenges in interpretation because of similarities in cytomorphological features between certain thyroid nodules and parathyroid tissue. Similarly, parathyroid lesions may go unnoticed for a long period of time because they are misinterpreted as thyroid lesions and patients with parathyroid lesions are typically oligo- or asymptomatic for a long period of time.

Case presentation
We present the case of a 57-year-old female patient who was under observation for a hormone inactive mildly suspicious thyroid nodule for eight years before the suspected thyroid nodule was found to be a parathyroid adenoma. Repeated fine needle aspiration biopsies showed cytomorphological features of Bethesda Class III thyroid nodules and the patient was asymptomatic throughout all consultations. Finally, a pathological hip fracture and symptomatic kidney stone prompted further diagnostic work-up, confirming primary hyperparathyroidism and exposing the suspected thyroid lesion for a parathyroid adenoma. After focused parathyroidectomy the patient fully recovered.

Clinical discussion
Systematic blood sampling for Calcium and parathyroid hormone levels, which has to become part of the usual work up for suspicious thyroid nodules, may have exposed the diagnosis earlier preventing secondary complications.

Conclusion
This case highlights one of the major pitfalls in ultrasound interpretation and fine needle aspiration biopsy of the thyroid gland. Physicians need to be aware of these difficulties during the diagnostic work-up.

Highlights
Effects of dietary vitamins on obesity-related metabolic parameters
Authors: Lee Chooi Yeng 
Published: April 2023

Abstract
Type 2 diabetes mellitus (T2DM) is one of the leading causes of death worldwide. Genetic factors, some underlying medical conditions, and obesity are risk factors of T2DM. Unlike other risk factors which are non-modifiable, obesity is preventable and usually treatable, and is largely contributed by lifestyle factors. Management of these lifestyle factors may curb the development of T2DM and reduces T2DM prevalence. Dietary vitamins have been recommended as a lifestyle modification intervention to support obesity treatment. Vitamins correlate negatively with body weight, body mass index and body composition. Some of the vitamins may also have anti-adipogenic, anti-inflammatory and antioxidant effects. However, results from pre-clinical and clinical studies of the effects of vitamins on obesity are inconsistent. A clear understanding of the effects of vitamins on obesity will help determine dietary intervention that is truly effective in preventing and treating obesity as well as obesity-related complications including T2DM. This article reviews existing evidences of the effects of vitamin supplementation on obesity and obesity-related metabolic status.
Divine subjectivity and intersubjectivity
Authors: Zagzebski Linda 
Published: April 2023

AbstractThis article expands my previous work on omnisubjectivity, the divine property of having a complete and perfect grasp of the subjective states of all beings who have such states. By a subjective state I mean a conscious state as that state is experienced by the one who has it. I argue that only a being with subjectivity can be omnisubjective, and therefore, God has subjective states. The article explores the subjectivity of God as it applies to the Christian doctrines of the Trinity and the Incarnation, focusing on the important difference between a person and an instance of a nature. I propose that the uniqueness of persons is grounded in their unique subjective states, not their objective nature. Each person of the Trinity has a unique point of view and unique subjectivity even though they share an objective divine nature instantiated in a single divine being. The Son has a single set of subjective states before, during, and after the Incarnation. Each member of the Trinity is omnisubjective and fully grasps the unique subjective states of each other person of the Trinity. The perfect comprehension of each other while remaining unique persons is a model of perfect love within a community of persons.
Abortion and Directive Genetic Counseling
Authors: Kearney Matthew 
Published: April 2023

AbstractThis multi-method study uses statistical and comparative-historical investigations to find that abortion values shape genetic counseling practices across societies. Genetic counselors and genetically interested social scientists have long questioned, but never systematically demonstrated, whether this relationship exists. Genetic counseling data are drawn from cross-national surveys of genetic counselors (n= 2,906) from the mid-1990s, the key historical moment after this profession was globally established but before potentially confounding transnational professional effects. Data focus on Trisomy 21, severe open spina bifida, and Huntington’s chorea. Abortion data are drawn from a new comparative-historical investigation of abortion attitudes in 36 countries based on law, frequency of policy debate, incidence rates, and public opinion polling. The key overall finding is that the more controversial abortion is within a society, the less directive genetic counselors are willing to be, whereas the less controversial abortion is, the more directive the counseling. Polynomial regressions,t-tests, likelihood ratios, and Wald tests provide statistical evidence for the relationship observed through qualitative clustering.
Ice Shelf Basal Melt Sensitivity to Tide‐Induced Mixing Based on the Theory of Subglacial Plumes
Authors: Anselin J. , Reed B. C. , Jenkins A. , Green J. A. M. 
Published: April 2023

AbstractTidal currents are known to influence basal melting of Antarctic ice shelves through two types of mechanisms: local processes taking place within the boundary current adjacent to the ice shelf‐ocean interface and far‐field processes influencing the properties of water masses within the cavity. The separate effects of these processes are poorly understood, limiting our ability to parameterize tide‐driven ice shelf‐ocean interactions. Here we focus on the small‐scale processes within the boundary current. We apply a one‐dimensional plume model to a range of ice base geometries characteristic of Antarctic ice shelves to study the sensitivity of basal melt rates to different representations of tide‐driven turbulent mixing processes. Our simulations demonstrate that tides can either increase or decrease melt rates depending on the approach chosen to parameterize entrainment of ambient water into the turbulent plume layer, a process not yet well constrained by observations. A theoretical assessment based on an analogy with tidal bottom boundary layers suggests that tide‐driven shear at the ice shelf‐ocean interface enhances mixing through the pycnocline. Under this assumption our simulations predict a tide‐induced increase in melt and freeze rates along the base of the ice shelf, with the strongest plume path‐integrated effects for cold cavities (up to +400% in the realistic set up). An approximation is provided to account for this response in basal melt rate parameterizations that neglect the effect of tide‐induced turbulent mixing.
Investigation of Martian Regional Crustal Structure Near the Dichotomy Using S1222a Surface‐Wave Group Velocities
Authors: Xu Zongbo , Broquet Adrien , Fuji Nobuaki , Kawamura Taichi , Lognonné Philippe , Montagner Jean‐Paul , Pan Lu , Schimmel Martin , Stutzmann Eléonore , Banerdt William Bruce 
Published: April 2023

AbstractKnowledge of Martian crust and uppermost mantle aid us studying the planet's evolution. NASA's InSight mission provides seismic data being used to reveal the interior structure. Most studies have focused on the crustal structure beneath InSight lander, but the seismic structure of other regions has remained poorly known. We use surface‐wave data to investigate the crustal structure of a large region along the Medusa Fossae Formation and the dichotomy. We adopt the largest‐magnitude marsquake (S1222a) that has been recorded, which provides both Rayleigh‐ and Love‐wave signals. We measure and jointly invert these surface‐wave fundamental‐mode group velocities from ∼15 to 40 s to estimate the average 1D isotropic velocity models. These models includes a high‐velocity layer at ∼7‐km depth, which could be due to a regional basaltic activity or regional stress. Our models also indicate that a common intra‐crustal structure (∼12–40 km depth) may exist in this region along the dichotomy.
Predictors of placebo response in three large clinical trials of the V1a receptor antagonist balovaptan in autism spectrum disorder
Authors: Tobe Russell , Zhu Yajing , Gleissl Teresa , Rossomanno Simona , Veenstra-VanderWeele Jeremy , Smith Janice , Hollander Eric 
Published: April 2023

AbstractHigh rates of placebo response are increasingly implicated in failed autism spectrum disorder (ASD) clinical trials. Despite this, there are limited investigations of placebo response in ASD. We sought to identify baseline predictors of placebo response and quantify their influence on clinical scales of interest for three harmonized randomized clinical trials of balovaptan, a V1a receptor antagonist. We employed a two-step approach to identify predictors of placebo response on the Vineland-II two-domain composite (2DC) (primary outcome and a caregiver measure) and Clinical Global Impression (CGI) scale (secondary outcome and a clinician measure). The initial candidate predictor set of variables pertained to participant-level, site-specific, and protocol-related factors. Step 1 aimed to identify influential predictors of placebo response using Least Absolute Shrinkage and Selection Operator (LASSO) regression, while Step 2 quantified the influence of predictors via linear regression. Results were validated through statistical bootstrapping approaches with 500 replications of the analysis dataset. The pooled participant-level dataset included individuals with ASD aged 5 to 62 years (mean age 21 [SD 10]), among which 263 and 172 participants received placebo at Weeks 12 and 24, respectively. Although no influential predictors were identified for CGI, findings for Vineland-II 2DC are robust and informative. Decreased placebo response was predicted by higher baseline Vineland-II 2DC (i.e., more advanced adaptive function), longer trial duration, and European (vs United States) sites, while increased placebo response was predicted by commercial (vs academic) sites, attention deficit hyperactivity disorder and depression. Identification of these factors may be useful in anticipating and mitigating placebo response in drug development efforts in ASD and across developmental and psychiatric conditions.