bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intervención temprana en la unidad de cuidado intensivo neonatal con seguimiento en casa dirigidas a las habilidades motoras de niños prematuros.
Authors: Hastamorir-Clavijo Lizeth Daniela , Molina Cárdenas Diana Carolina , Castellanos Garrido Adriana Lucía 
Published: January 2023

Introducción: La prematurez es una importante causa de morbimortalidad perinatal asociado a un mayor riesgo neurológico esto debido a que entre las semanas 20 y 37 de gestación ocurre un rápido crecimiento cortical, particularmente de las áreas sensoriomotoras lo cual afecta potencialmente el neurodesarrollo. Desde diferentes campos se han propuesto estrategias que buscan prevenir que el cerebro sea lesionado por la estimulación intensa y dolorosa conocidas como “Cuidados centrados en el desarrollo”. Sin embargo, se reporta escasa literatura disponible a nivel nacional que proporcione evidencia de la efectividad de la intervención temprana que favorezca el desarrollo de las habilidades motoras de los bebés en la Unidad de Cuidado intensivo neonatal (UCIN). Por lo cual, el objetivo de este estudio es conocer las estrategias de intervención temprana utilizadas para mejorar las habilidades motoras en bebés prematuros según lo reportado en la literatura. Método: Se llevó a cabo una revisión de literatura en 3 bases de datos (Scopus, Clinicalkey y ScienceDirect) durante los años 2016 a 2020. Resultados: Se revisaron 7 artículos cuyo idioma prevalente es el inglés sobre estrategias de intervención que inician en la UCIN y continúan con seguimiento en el hogar. Conclusiones: En algunos estudios no se logra evidenciar claramente una dosificación de las intervenciones realizadas. A su vez, la participación activa de los padres es fundamental para la adquisición de habilidades motoras en esta población, donde el fisioterapeuta es primordial en el entrenamiento, guía y acompañamiento del proceso con la familia.
Multiple pathways of SARS-CoV-2 nosocomial transmission uncovered by integrated genomic and epidemiological analyses during the second wave of the COVID-19 pandemic in the UK
Authors: Cook Kate F. , Beckett Angela H. , Glaysher Sharon , Goudarzi Salman , Fearn Christopher , Loveson Katie F. , Elliott Scott , Wyllie Sarah , Lloyd Allyson , Bicknell Kelly , Lumley Sally , Chauhan Anoop J. , Robson Samuel C. ,   The COVID-19 Genomics UK (COG-UK) consortium
Published: January 2023

IntroductionThroughout the global COVID-19 pandemic, nosocomial transmission has represented a major concern for healthcare settings and has accounted for many infections diagnosed within hospitals. As restrictions ease and novel variants continue to spread, it is important to uncover the specific pathways by which nosocomial outbreaks occur to understand the most suitable transmission control strategies for the future.MethodsIn this investigation, SARS-CoV-2 genome sequences obtained from 694 healthcare workers and 1,181 patients were analyzed at a large acute NHS hospital in the UK between September 2020 and May 2021. These viral genomic data were combined with epidemiological data to uncover transmission routes within the hospital. We also investigated the effects of the introduction of the highly transmissible variant of concern (VOC), Alpha, over this period, as well as the effects of the national vaccination program on SARS-CoV-2 infection in the hospital.ResultsOur results show that infections of all variants within the hospital increased as community prevalence of Alpha increased, resulting in several outbreaks and super-spreader events. Nosocomial infections were enriched amongst older and more vulnerable patients more likely to be in hospital for longer periods but had no impact on disease severity. Infections appeared to be transmitted most regularly from patient to patient and from patients to HCWs. In contrast, infections from HCWs to patients appeared rare, highlighting the benefits of PPE in infection control. The introduction of the vaccine at this time also reduced infections amongst HCWs by over four-times.DiscussionThese analyses have highlighted the importance of control measures such as regular testing, rapid lateral flow testing alongside polymerase chain reaction (PCR) testing, isolation of positive patients in the emergency department (where possible), and physical distancing of patient beds on hospital wards to minimize nosocomial transmission of infectious diseases such as COVID-19.
Prevalence of hypertension and correlation with mental health in women with burning mouth syndrome: A case-control study
Authors: Canfora Federica , Calabria Elena , Pecoraro Giuseppe , Leuci Stefania , Coppola Noemi , Mazzaccara Cristina , Spirito Francesca , Aria Massimo , D'Aniello Luca , Mignogna Michele Davide , Adamo Daniela 
Published: January 2023

BackgroundThe relationship between hypertension (HTN) and chronic pain is still a matter of debate, and its prevalence in patients with burning mouth syndrome (BMS) has never been evaluated. This study aimed to assess the prevalence of HTN in women with BMS and to evaluate its relationship with potential predictors such as risk factors for cardiovascular diseases, pain, and mental health status analyzing differences with healthy women.MethodsIn total, 250 women with BMS (WBMS) were prospectively recruited and compared with an equal number of healthy women (HW) matched for age. Education, body mass index, smoke and alcohol consumption, intensity and quality of pain, and psychological profile were further investigated to identify the potential predictors of HTN. Specifically, pain assessment [the Numeric Rating Scale (NRS) and Short-Form McGill Pain Questionnaire (SF-MPQ)] and psychological assessment [Hamilton Rating Scale for Depression and Anxiety (HAM-D and HAM-A), Pittsburgh Sleep Quality Index (PSQI), and Epworth Sleepiness Scale (ESS)] was carried out for the participants.ResultsHTN was found in 128 (51.2%) WBMS and 76 (30.4%) HW (p &lt; 0.001**). The scores of the NRS, SF-MPQ, HAM-D, HAM-A, and PSQI were statistically significantly higher in the WBMS than in the HW (p &lt; 0.001**). A strongly linear correlation between HTN and employment status, systemic diseases, and education level (p &lt; 0.001**) was found in WBMS, while a strong correlation between HTN and employment status, hypercholesterolemia, systemic diseases, and drug consumption was found in HW (p &lt; 0.001**). No statistically significant correlation was found between HTN and pain, anxiety, depression, and sleep disturbances.ConclusionThese results suggest that WBMS showed a higher prevalence of HTN compared with controls. Unemployed WBMS with lower education and other systemic comorbidities are at an increased risk of developing HTN. HTN is associated with alteration in the vascular structure and function of the brain, and these processes accelerate brain aging, which contributes to a reduction in intracortical connectivity, thus affecting the modulatory system of control of pain in patients with BMS, independently of their mental health assessment. Predictors that may underlie this association remain unclear, taking into account the differences found in HW, and should be further elucidated.
Study on the pore structure characteristics and damage constitutive model of sandstone under freeze-thaw conditions
Authors: Ma Junzu , Jin Jiaxu , Wu Pengfei , Qin Zhifa , Jia Baoxin 
Published: January 2023

Rocks in Northwest China are often affected by the combined action of freeze-thaw and load erosion. Therefore, in order to better understand the mechanical properties of rocks in seasonal frozen areas and the meso-damage caused by freeze-thaw erosion, uniaxial compression tests, electron microscope scanning tests, X-ray diffraction tests (XRD) and mercury intrusion tests (MIP) were carried out on five sandstone samples with different freeze-thaw times, and the mechanical parameters and meso-damage characteristics of sandstone samples with different freeze-thaw times were obtained. Fractal theory was used to analyze the change in pore volume of sandstone after freeze-thaw cycles. Finally, the damage constitutive equation under the coupling action of freeze-thaw damage and load was established based on Lemaitre’s equivalent effect variation criterion. The results showed that the type of sandstone is a porous coarse-grained sandstone. With the increased freeze-thaw times, the compressive strength and cohesion of sandstone gradually decreased, and the closed pores in sandstone gradually connected, leading to the visible internal macroscopic cracks. Affected by freeze-thaw times, the volume proportion of large pores (100–1,000 µm) in sandstone gradually increased, while the volume proportion of micropores (.05–100 µm) gradually decreased. With the increased freeze-thaw times, the fractal dimension of pore volume decreased from 1.94 to 1.59. The theoretical curve can better fit the characteristic points of the stress-strain curve, which can further reveal the damage mechanism of sandstone under the coupling effects of freeze-thaw and load. The minimum error between the peak point of the experimental curve and the theoretical curve is 3.3%.
Integrated lipids biomarker of the prediabetes and type 2 diabetes mellitus Chinese patients
Authors: Yang Jiaying , Wang Mei , Yang Dawei , Yan Han , Wang Zhigang , Yan Dan , Guo Na 
Published: January 2023

IntroductionDyslipidemia is a hallmark of T2DM, and as such, analyses of lipid metabolic profiles in affected patients have the potential to permit the development of an integrated lipid metabolite-based biomarker model that can facilitate early patient diagnosis and treatment.MethodsUntargeted and targeted lipidomics approaches were used to analyze serum samples from newly diagnosed 93 Chinese participants in discovery cohort and 440 in validation cohort via UHPLC-MS and UHPLC-MS/MS first. The acid sphingomyelinase protein expression was analyzed by Western blot.Results and DiscussionThrough these analyses, we developed a novel integrated biomarker signature composed of LPC 22:6, PC(16:0/20:4), PE(22:6/16:0), Cer(d18:1/24:0)/SM(d18:1/19:0), Cer(d18:1/24:0)/SM(d18:0/16:0), TG(18:1/18:2/18:2), TG(16:0/16:0/20:3), and TG(18:0/16:0/18:2). The area under the curve (AUC) values for this integrated biomarker signature for prediabetes and T2DM patients were 0.841 (cutoff: 0.565) and 0.894 (cutoff: 0.633), respectively. Furthermore, theresults of western blot analysis of frozen adipose tissue from 3 week (prediabetes) and 12 week (T2DM) Goto–Kakizaki (GK) rats also confirmed that acid sphingomyelinase is responsible for significant disruptions in ceramide and sphingomyelin homeostasis. Network analyses of the biomarkers associated with this biosignature suggested that the most profoundly affected lipid metabolism pathways in the context of diabetes include de novo ceramide synthesis, sphingomyelin metabolism, and additional pathways associated with phosphatidylcholine synthesis. Together, these results offer new biological insights regarding the role of serum lipids in the context of insidious T2DM development, and may offer new avenues for future diagnostic and/or therapeutic research.
An online tool for predicting ovarian responses in unselected patients using dynamic inhibin B and basal antimüllerian hormone levels
Authors: Ma Congcong , Xu Huiyu , Wang Haiyan , Feng Guoshuang , Han Yong , Alpadi Kannan , Li Rong , Qiao Jie 
Published: January 2023

BackgroundReliable predictive models for predicting excessive and poor ovarian response in controlled ovarian stimulation (COS) is currently lacking. The dynamic (Δ) inhibin B, which refers to increment of inhibin B responding to exogenous gonadotropin, has been indicated as a potential predictor of ovarian response.ObjectiveTo establish mathematical models to predict ovarian response at the early phase of COS using Δinhibin B and other biomarkers.Materials and methodsProspective cohort study in a tertiary teaching hospital, including 669 cycles underwent standard gonadotropin releasing hormone (GnRH) antagonist ovarian stimulation between April 2020 and September 2020. Early Δinhibin B was defined as an increment in inhibin B from menstrual day 2 to day 6 through to the day of COS. Least Absolute Shrinkage and Selection Operator (LASSO) logistic regression with 5-fold cross-validation was applied to construct ovarian response prediction models. The area under the receiver operating characteristic curve (AUC), prevalence, sensitivity, and specificity were used for evaluating model performance.ResultsEarly Δinhibin B and basal antimüllerian hormone (AMH) levels were the best measures in building models for predicting ovarian hypo- or hyper-responses, with AUCs and ranges of 0.948 (0.887–0.976) and 0.904 (0.836–0.945) in the validation set, respectively. The contribution of the early Δinhibin B was 67.7% in the poor response prediction model and 56.4% in the excessive response prediction model. The basal AMH level contributed 16.0% in the poor response prediction model and 25.0% in the excessive response prediction model. An online website-based tool (http://121.43.113.123:8001/) has been developed to make these complex algorithms available in clinical practice.ConclusionEarly Δinhibin B might be a novel biomarker for predicting ovarian response in IVF cycles. Limiting the two prediction models to the high and the very-low risk groups would achieve satisfactory performances and clinical significance. These novel models might help in counseling patients on their estimated ovarian response and reduce iatrogenic poor or excessive ovarian responses.
Carbon dioxide partial pressures and emissions of the Yarlung Tsangpo River on the Tibetan Plateau
Authors: Bao Yufei , Hu Mingming , Li Shanze , Wang Yuchun , Wen Jie , Wu Xinghua , Sun Meng , Du Pengcheng 
Published: January 2023

Rivers are important routes for material and energy transport between terrestrial and marine ecosystems. Recent global-scale assessments of carbon (C) have suggested that C emission fluxes to the atmosphere are comparable to the fluvial C fluxes to the ocean. However, many previous studies only collected data from inland rivers in low altitude regions. Therefore, it remains unclear how plateau rivers affect C flux. In this study, 20 monitoring sites were set up along the Yarlung Tsangpo (YT) River on the Tibetan Plateau and detailed observations were carried out in the wet and dry seasons. The riverine CO2 fluxes exhibited significant seasonal patterns which ranged from 597.12 ± 292.63 μatm in the wet season to 368.72 ± 123.50 μatm in the dry season. The CO2 emission flux (FCO2) obtained from floating chamber method, ranging from 8.44 ± 6.94 mmol m−2 d−1 in sunmmer to 3.62 ± 6.32 mmol m−2 d−1 in winter, with an average value of 6.03 mmol m−2 d−1. Generally, the river was a weak carbon source with respect to the atmosphere. However, the pCO2 and FCO2 were much lower than that for other large rivers around the globe, which were obviously restrained by the weak microbial activities due to the low primary productivity and carbonate buffer activities in the carbonate background. Carbon loss via atmosphere exchange in the YT River on the plateau accounted for 2.2% and 10.6% of the riverine dissolved carbon fluxes (67.77 × 109 mol a−1) according to the floating chamber and thin boundary layer methods, respectively. The YT River probably acts as a “pipeline” to transport weathered nutrients from the plateau to downstream areas. Our results demonstrated the characteristics of a “weak outgassing effect and a high transport flux of carbon” for the plateau river, which is different from rivers on plains. Considering the global relevance of Tibetan Plateau, further studies with enhanced spatiotemporal resolution are needed to better understand the important role of plateau rivers on carbon budgets and climate change over both regional and global cycles.
Construction and verification of a novel prognostic risk model for kidney renal clear cell carcinoma based on immunity-related genes
Authors: Liu Yufeng , Wu Dali , Chen Haiping , Yan Lingfei , Xiang Qi , Li Qing , Wang Tao 
Published: January 2023

Background: Currently, there are no useful biomarkers or prognostic risk markers for the diagnosis of kidney renal clear cell carcinoma (KIRC), although recent research has shown that both, the onset and progression of KIRC, are substantially influenced by immune-associated genes (IAGs).Objective: This work aims to create and verify the prognostic value of an immune risk score signature (IRSS) based on IAGs for KIRC using bioinformatics and public databases.Methods: Differentially expressed genes (DEGs) related to the immune systems (IAGs) in KIRC tissues were identified from The Cancer Genome Atlas (TCGA) databases. The DEGs between the tumor and normal tissues were identified using gene ontology (GO) and Kyoto Encyclopaedia of Genes and Genomes (KEGG) enrichment analyses. Furthermore, a prognostic IRSS model was constructed and its prognostic and predictive performance was analyzed using survival analyses and nomograms. Kidney renal papillary cell carcinoma (KIRP) sets were utilized to further validate this model.Results: Six independent immunity-related genes (PAEP, PI3, SAA2, SAA1, IL20RB, and IFI30) correlated with prognosis were identified and used to construct an IRSS model. According to the Kaplan-Meier curve, patients in the high-risk group had significantly poorer prognoses than those of patients in the low-risk group in both, the verification set (p &lt;0.049; HR = 1.84; 95% CI = 1.02–3.32) and the training set (p &lt; 0.001; HR = 3.12, 95% CI = 2.23–4.37). The numbers of regulatory T cells (Tregs) were significantly positively correlated with the six immunity-related genes identified, with correlation coefficients were 0.385, 0.415, 0.399, 0.451, 0.485, and 0.333, respectively (p &lt;0.001).Conclusion: This work investigated the association between immune infiltration, immunity-related gene expression, and severity of KIRC to construct and verify a prognostic risk model for KIRC and KIRP.
Dupilumab for the treatment of prurigo nodularis: A systematic review
Authors: Cao Peng , Xu Wenjing , Jiang Shuyi , Zhang Litao 
Published: January 2023

BackgroundConventional treatment techniques have limited efficacy and more side effects in the treatment of prurigo nodularis. The better alternative treatment option for better outcomes of the disease is dupilumab.ObjectiveThe objective of this study was to systematically review dupilumab-related treatment outcomes in prurigo nodularis.MethodsSeveral databases like Embase, PubMed, Web of Science, and Cochrane library were searched for data acquisition on October 8, 2022. Based on Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines, 24 publications were included in this study.ResultsAfter 4,12,16 and more than 16 weeks of dupilumab treatment, 8.3% (n=5/60), 34.4% (n=11/32), 3.6% (n=2/56), and 45.3% (n=29/64) of patients had complete remission, respectively. In addition, 85.0% (n=51/60), 59.4% (n=19/32), 83.9% (n=47/56), and 43.8% (n=28/64) had partial remission, respectively. Moreover, 6.7% (n=4/60), 6.3% (n=2/32), 12.5% (n=7/56), and 10.9% (n=7/64) showed no remission, respectively, and significant reduction of numeric rating scale itch intensity (from 9.0 to 4.9, 2.1, 2.8, 0.9) was attained. There were no serious adverse events observed during treatment, but the most common event observed was conjunctivitis (12.6%, n=15/119).ConclusionsDupilumab has definite effectiveness and safety in prurigo nodularis treatment.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO, identifier (CRD42022365802).
Ten-year follow-up of infliximab treatment for uveitis in Behçet disease patients: A multicenter retrospective study
Authors: Takeuchi Masaru , Usui Yoshihiko , Namba Kenichi , Keino Hiroshi , Takeuchi Masaki , Takase Hiroshi , Kamoi Koju , Hase Keitaro , Ito Takako , Nakai Kei , Maruyama Kazuichi , Kobayashi Eri , Mashimo Hisashi , Sato Tomohito , Ohguro Nobuyuki , Hori Junko , Okada Annabelle A. , Sonoda Koh-hei , Mizuki Nobuhisa , Goto Hiroshi 
Published: January 2023

PurposeTo evaluate 10-year outcome of infliximab (IFX) treatment for uveitis in Behçet disease (BD) patients using a standardized follow-up protocol.DesignRetrospective longitudinal cohort study.Participants140 BD uveitis patients treated with IFX enrolled in our previous study.MethodsMedical records were reviewed for demographic information, duration of IFX treatment, number of ocular attacks before IFX initiation, best corrected visual acuity (VA) at baseline and 1, 2, 3, 4, 5, and 10 years after IFX initiation, uveitis recurrence after IFX initiation and main anatomical site, concomitant therapies, and adverse events (AEs).Main outcome measures10-year IFX continuation rate and change in LogMAR VA.ResultsOf 140 BD patients, 106 (75.7%) continued IFX treatment for 10 years. LogMAR VA improved gradually after initiation of IFX, and the improvement reached statistical significance from 2 years of treatment. Thereafter, significant improvement compared with baseline was maintained until 10 years, despite a slight deterioration of logMAR VA from 5 years. However, eyes with worse baseline decimal VA &lt; 0.1 showed no significant improvement from baseline to 10 years. Uveitis recurred after IFX initiation in 50 patients (recurrence group) and did not recur in 56 (non-recurrence group). Ocular attacks/year before IFX initiation was significantly higher in the recurrence group (2.82 ± 3.81) than in the non-recurrence group (1.84 ± 1.78). In the recurrence group, uveitis recurred within 1 year in 58% and within 2 years in 74%. Seventeen patients (34%) had recurrent anterior uveitis, 17 (34%) had posterior uveitis, and 16 (32%) had panuveitis, with no significant difference in VA outcome. In addition, logMAR VA at 10 years did not differ between the recurrence and non-recurrence groups. AEs occurred among 43 patients (30.7%), and 24 (17.1%) resulted in IFX discontinuation before 10 years.ConclusionsAmong BD patients with uveitis who initiated IFX, approximately 75% continued treatment for 10 years, and their VA improved significantly and was maintained for 10 years. Uveitis recurred in one-half of the patients, but visual acuity did not differ significantly from the patients without recurrence.
Encephalitis and cytokine storm secondary to respiratory viruses in children: Two case reports
Authors: Santos Pollyana C. P. , Holloway Adrian J. , Custer Jason W. , Alves Tomaz , Simon Liliana 
Published: January 2023

IntroductionEncephalitis is a syndrome characterized by brain damage secondary to an inflammatory process that is manifested by cognitive impairment and altered cerebral spinal fluid analysis; it may evolve with seizures and coma. Despite viral infections representing the main cause of encephalitis in children, respiratory syncytial virus (RSV) and parainfluenza virus are mostly associated with respiratory presentations. Uncommonly, the inflammatory phenomena from encephalitis secondary to viral agents may present with an exacerbated host response, the so-called cytokine storm. The link between these infectious agents and neurologic syndromes resulting in a cytokine storm is rare, and the underlying pathophysiology is still poorly understood.Case presentationA 5-year-old girl and a 2-year-old boy infected with parainfluenza and RSV, respectively, were identified through nasopharyngeal polymerase chain reaction. They were admitted into the pediatric intensive care unit due to encephalitis and multiple organ dysfunction manifested with seizures and hemodynamic instability. Magnetic resonance imaging findings from the first patient revealed a bilateral hypersignal on fluid-attenuated inversion recovery in the cerebral hemispheres, especially in the posterior parietal and occipital regions. The girl also had elevated IL-6 levels during the acute phase and evolved with a fast recovery of the clinical presentations. The second patient progressed with general systemic complications followed by cerebral edema and death.ConclusionEncephalitis secondary to respiratory viral infection might evolve with cytokine storm and multiorgan inflammatory response in children.