bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mental Health Literacy programmes prevent and support ongoing management of youth anxiety and depression: consultation and literature review
Authors: Botero-Rodríguez Felipe , Dhakal Sandesh , Pizarro Ana Beatriz , Koirala Rupesh , Khanal Astha , Peralta-Cuervo Andrés Felipe , Tandukar Dipesh , Khadgi Nalina , Bird Victoria , Lau Jennifer YF 
Published: September 2023

Abstract

Background
Enhancing young people's capacity to recognise, understand and manage emotional symptoms through mental health literacy (MHL) programmes may help attenuate the long-term burden of mental illness. This may be especially important in low-resource settings. We aimed to review the capacity of MHL programmes to prevent, support ongoing management, and reduce relapse of youth anxiety and depression. We explored both personal and contextual factors that could amplify their benefits, and through consultations with lived experience researchers, considered if and how these could be delivered in low-resource settings.
Methods
We systematically searched 6 databases for studies that evaluated the potential of MHL programmes to prevent, support ongoing management, and reduce relapse of youth anxiety and depression. We consulted young people and stakeholders on their perception of MHL programme delivery in low-resource countries/settings.
Results
We identified 17 relevant studies, covering a range of MHL programmes. Most MHL programmes targeted young people through educational settings. Teacher-delivered programs showed the clearest effects in improving recognition of anxiety/depression symptoms while programs supported by experts showed clearer effects on stigma reduction. Stakeholders highlighted the importance of MHL programmes and expressed possible barriers and solutions to implement them.
Conclusion
As young people are receptive to learning about mental health, it is critical to implement accessible MHL interventions early, especially in low-resource settings. Delivery by non-specialist practitioners in community settings could reflect one such strategy. Delivering these programmes may be a pre-requisite to understanding why and when individual resources are needed, bridging the gap in availability of mental health care.
Sex- and age-dependent susceptibility to ventricular arrhythmias in the rat heart ex vivo.
Authors: Okninska Marta , Duda Monika , Czarnowska Elżbieta , Bierla Joanna , Paterek Aleksandra , Maczewski Michal , Mackiewicz Urszula 
Published: September 2023

Abstract
Background
The incidence of life-threatening ventricular arrhythmias, the most common cause of sudden cardiac death (SCD), depends largely on the arrhythmic substrate that develops in the myocardium during the aging process. There is a huge deficit of comparative studies on the development of this substrate in both sexes, with a particular paucity of studies in females.
Methods
To identify the substrate of arrhythmia, fibrosis, cardiomyocyte hypertrophy, mitochondrial density, level of oxidative stress, antioxidant defense and intracellular Ca2+ signaling in isolated cardiomyocytes were measured in the hearts of 3- and 24-month-old female and male rats. Arrhythmia susceptibility was assessed in ex vivo perfused hearts after exposure to isoproterenol (ISO) and hydrogen peroxide (H2O2). The number of ventricular premature beats (PVBs), ventricular tachycardia (VT) and ventricular fibrillation (VF) episodes, as well as intrinsic heart rate, QRS and QT duration, were measured in ECG signals recorded from the surfaces of the beating hearts.
Results
After ISO administration, VT/VFs were formed only in the hearts of males, mainly older ones. In contrast, H2O2 led to VT/VF formation in the hearts of rats of both sexes but much more frequently in older males. We identified several components of the arrhythmia substrate that develop in the myocardium during the aging process, including high spontaneous ryanodine receptor activity in cardiomyocytes, fibrosis of varying severity in different layers of the myocardium (nonheterogenic fibrosis), and high levels of oxidative stress as measured by nitrated tyrosine levels. All of these elements appeared at a much higher intensity in male individuals during the aging process. On the other hand, in aging females, antioxidant defense at the level of H2O2 detoxification measured as glutathione peroxidase expression was weaker than in males of the same age.
Conclusion
We have shown that sex has a significant effect on the development of an arrhythmic substrate in aging. This substrate determines the incidence of life-threatening ventricular arrhythmias in the presence of additional stimuli with proarrhythmic potential, such as catecholamine stimulation or oxidative stress, which are constant elements in the pathomechanism of most cardiovascular diseases.
Propensity Score Matched Analysis for the Safety and Effectiveness of Remdesivir in COVID-19 Patients with Renal Impairment
Authors: Yang Eunmi , Choi Han Zo , Kim Subin , Oh Dong Hyun , Ahn Mi Young , Ham Sinyoung , Lee Eunyoung , Jeon Jaehyun , Kim Min-Kyung , Jang Hee-Chang , Park Sang-Won , Choi Jae-Phil 
Published: September 2023

Abstract
Backgrounds:
Remdesivir (RDV) is an antiviral agent approved for the treatment of coronavirus disease 2019 (COVID-19); however, is not recommended for patients with renal impairment. Due to limitations associated with prospective clinical trials, real-world data on the safety and efficacy of RDV in patients with renal impairment are necessary.
Methods
Propensity score-matched (PSM) retrospective analysis was conducted between March 2020 and September 2022 in COVID-19 patients with an eGFR < 30 mL/min in four Korean hospitals. The RDV treatment group was matched to the untreated control group. The safety and clinical outcomes in patients who received RDV were analyzed.
Results
A total of 564 patients were enrolled; 229 patients received RDV either for treatment or prophylaxis. On day 5, no differences in nephrotoxicity and hepatotoxicity were observed between the two groups. In multivariate analysis for new dialysis, RDV treatment was not a risk factor for new dialysis. Among the 564 patients, 417 were indicated for a 5-day course of RDV treatment and 211 patients were treated with RDV. After PSM, no differences in the clinical outcomes were observed between the two groups.
Conclusion
RDV use in COVID-19 patients with renal impairment did not result in significant nephrotoxicity or hepatotoxicity.
Criteria for Severe Dynamic Sagittal Imbalance in Adult Spinal Deformity and its Importance
Authors: Kim Yong-Chan , Ha Kee-Yong , Kim Sung-Min , Yoo Sunin , Li Xiongjie 
Published: September 2023

Abstract
Background
To analyze the characteristics of “severe” dynamic sagittal imbalance (DSI) in patients with adult spinal deformity (ASD) and establish criteria for them.
Methods
In total, 102 ASD patients with four cardinal signs of lumbar degenerative kyphosis were retrospectively analyzed. All patients underwent deformity corrective surgery and were divided into three groups according to the diagnostic criteria. The criteria were based on the Oswestry disability index scores and dynamic features (△Timewalk: time until C7 sagittal vertical axis [C7SVA] reaches ≥ 20 cm after the start of walking) of sagittal imbalance. The paravertebral back muscles were analyzed and compared using T2-weighted axial images. We performed a statistically time-dependent spinopelvic sagittal parameter analysis on full standing lateral lumbar radiographs. Lumbar flexibility was analyzed based on dynamic lateral lumbar radiographs
Results
Based on the diagnostic criteria, the 102 patients were classified into three groups: mild (△Timewalk ≥ 180 s, 35 patients), moderate (180 s > △Timewalk ≥ 30 s, 38 patients), and severe (△Timewalk < 30 s, 29 patients). There was a significantly higher signal intensity (533.4 ± 237.5, P < 0.05) and larger area of fat infiltration (35.2 ± 5.4, P < 0.05) in the back muscles of the severe group than in the mild (223.8 ± 67.6/22.9 ± 11.9) and moderate groups (294.4 ± 214.7/21.6 ± 10.6). The analysis of lumbar flexibility revealed significantly lower values in the severe group (5.8° ± 2.5°, P < 0.05) than in the mild and moderate groups (14.2° ± 12.4° and 11.4° ± 8.7°, respectively). The severe group had significantly lower lumbar lordosis (LL, 25.1° ± 22.7°, P < 0.05) and Pelvic incidence (PI)-LL mismatch (PI-LL, 81.5° ± 26.6°, P < 0.001) than the mild (8.2 ° ± 16.3°/58.7° ± 18.8°) and moderate (14.3° ± 28.6°/66.8° ± 13.4°) groups. In ROC curve analysis, PI-LL was statistically significant with AUC of 0.810 (95% confidence interval) when the baseline was set at 75.3°. The severe group showed more postoperative complications than the other groups.
Conclusions
We suggest the following criteria for severe DSI: C7SVA > 20 cm within 30 s after walking or standing, rigid lumbar curve < 10° on dynamic lateral radiographs, and PI-LL mismatch > 75.3°.
The importance of landscape during long-distance running activity
Authors: Gajdek Agata , Kasprzyk Idalia , Ortyl Bernadetta 
Published: September 2023

Abstract

Running outdoor has a positive impact on human health. Study attempted to address the issue of what are other aspects motivating to take up running. We were particularly interested in the landscape. Goal was also to determine the landscape values of the competition routes, which determine their popularity. We conducted surveys among the participants of the runs and spatial analyzes using GIS tools. Great landscape values of running routes can contribute to the activation of running society, especially women and city dwellers. The high diversity of the landscape of the cross-country routes, especially in terms of their relief and land use, significantly affects their high landscape rating. Route profile and running challenges are as important as landscape values. The landscape that runners observe during long-distance runs affects their regeneration and motivates them to finish the competition. People want to run in a visually beautiful mountain and foothill landscape. This study illuminates how the enchanting tapestry of landscapes not only fuels the passion for outdoor running but also underscores the intricate relationship between humans and their surroundings. The results enable us to establish the key principles for designing new running routes that support runners during their exertion.
Is adrenal venous sampling always necessary to differentiate between unilateral and bilateral primary aldosteronism? Lesson from the SPAIN-ALDO register
Authors: Ramírez Paola Parra , Marcos Patricia Martín Rojas , Fano Miguel Paja , Boillos Marga González , Peris Begoña Pla , Pascual-Corrales Eider , Cano Ana María García , Ruiz-Sanchez Jorge Gabriel , Delgado Almudena Vicente , Hoyos Emilia Gómez , Ferreira Rui , Sanz Iñigo García , Sala Mònica Recasens , Millan Rebeca Barahona San , César María José Picón , Guardiola Patricia Díaz , Perdomo Carolina María , Manjón-Miguélez Laura , Centeno Rogelio García , Percovich Juan Carlos , Román Ángel Rebollo , Gimeno Paola Gracia , Lázaro Cristina Robles , Ruiz Manuel Morales , Calatayud María , Collao Simone Andree Furio , Meneses Diego , Nuñez Miguel Antonio Sampedro , Quesada Verónica Escudero , Ribas Elena Mena , Sánchez Alicia Sanmartín , Diaz César Gonzalvo , Oliveira Cristina Lamas , Guerrero-Vázquez Raquel , Tous María Del Castillo , Gotarredona Joaquín Serrano , Alevras Theodora Michalopoulou , Mateo Eva María Moya , Hanzu Felicia Alexandra , Araujo-Castro Marta 
Published: September 2023

Abstract
Purpose: To evaluate whether the clinical, biochemical and radiological features of patients with primary aldosteronism (PA) can predict both main subtypes of PA.
Methods: A retrospective multicenter study of PA patients followed in 27 Spanish tertiary hospitals (SPAIN-ALDO Register). Only patients with confirmed unilateral or bilateral PA based on adrenal venous sampling (AVS) and/or postsurgical biochemical cure after adrenalectomy were included. Supervised regression techniques were used for model development.
Results: 328 patients [270 unilateral PA (UPA), 58 bilateral PA (BPA)] were included. The area under the curve (AUC) for aldosterone/potassium ratio and aldosterone responses following saline infusion test were 0.602 [95%CI 0.520 to 0.684] and 0.574 [95% CI 0.446-0.701], respectively, to differentiate UPA from BPA. The AUC was 0.825 [95% 0.764-0.886] when the prediction model with seven parameters – comorbidities (dyslipidemia, cerebrovascular disease, SAS), SBP, plasma aldosterone levels (PAC), hypokalemia and unilateral adrenal nodule >1 cm and normal contralateral adrenal gland on CT/MRI – was used. In patients without comorbidities, hypokalemia, SBP >160 mmHg, PAC >40 ng/dL, and unilateral adrenal lesions were associated with a likelihood of having a UPA of 98.5%. The chance of BPA was higher in individuals with comorbidities, SBP <140 mmHg, normokalemia, low PAC levels, and no adrenal tumors on the CT/MRI (91.5%).
Conclusion: A combination of high PAC, SBP >160 mmHg, low serum potassium, a unilateral adrenal nodule and no comorbidities could predict a UPA with a 98.5% accuracy.
Flood Risk Assessment Based on the Historical Disaster Statistics and the Index System Method: A Case Study of Hubei Province, China
Authors: Che Lusheng , Yin Shuyan , Guo Yishu 
Published: September 2023

Abstract
Flood risk assessment is a critical aspect of flood management. The historical disaster statistics method and the index system method are commonly employed for this purpose. In this study, we combine these approaches to assess the risk of flooding in Hubei province, China. Our methodology includes compiling flood disaster data from 1949 to 2000 to calculate the flood disaster extent and trend in each geographic unit, and flood hazard is assessed using these aspects. Additionally, we also select relevant indicators such as elevation difference, distance to water bodies, GDP, population, and percentage of construction land as flood vulnerability measures, and the weights for these indicators are determined using the Analytic Hierarchy Process (AHP). Subsequently, a risk assessment model is developed by integrating the hazard and vulnerability factors, and the flood risk assessment is conducted at a high-resolution grid scale of 1km × 1km. The results show that about 36.7% of the territory of Hubei Province falls into the medium-high risk category. It is observed that the risk level is higher in the eastern and southern regions, and lower in the western and northern regions. Notably, flood risk decreases radially outward from two high-value centers such as Wuhan and Yichang. Our assessment method demonstrates operational simplicity, high accuracy, and robustness. Moreover, the assessment results provide a high spatial resolution that can be further refined to the relative risks in different administrative hierarchical areas.
Health Economic Comparisonof Retrievable Self-expanding Full-covered Film Metal Stent and Endoscopic Dilation for Benign Anastomotic Stenosis after Esophagectomy of Esophageal Cancer: A Randomized Controlled Trial
Authors: Tao Zhang , Liu Jie , Pu Wenfeng , Ren Ninchuan , Feng Shenggang , Zhang Yan , Zhang Lisha , Li Feng , He Qingli , Lin Fengying , Du Zhonghan , Hu Xiaosan , Li Baohua , Zhang Guihua , Long Sizhe , Li Ying , Zhang Bing 
Published: September 2023

Abstract
Background: Endoscopic dilation (ED) is common and effective for improving strictures in patients with benign esophageal anastomotic stenosis (BEAS) after esophagectomy. A retrievable self-expanding metal stent has also been proven effective in treating strictures. However, evaluations comparing health economics of stent placement and ED for BEAS are lack.
Methods: In this prospective, randomized, controlled, multicenter study, BEAS patients between October 2020 and October 2021 at six centers were included. Patients were randomized into stent replacement (SR) or water balloon dilation (WBD) groups, and re-treatment interval times, body mass index (BMI) changes, dysphagia score, quality of life (QOL), treatment fees/times, total cost, daily cost, restenosis, and adverse effects assessed. Mann-Whitney U test was used for continuous variable analysis and Kaplan-Meier to calculate cumulative percentage and effective rate; significance was set at P<0.05.
Results: Re-treatment interventions were more frequent in the WBD group (3 vs. 1.2, p<0.05) and re-treatment interval times longer (60-days vs. 7-days, p<0.05). Patient compliance was lower in the WBD group (p<0.001), while treatment cost was higher in SR patients (5001 vs. 1812 yuan, p <0.001). Daily treatment cost was lower in SR patients (78.57 vs 86.29 yuan, p<0.05). QOL (97 vs. 86, p<0.05), changes in posttreatment BMI (0 vs -0.72, p<0.05), and posttreatment dysphagia score (1 vs. 2, p<0.05) were higher in SR patients. There were three adverse events, two stent migrations, and one patient died following ED.
Conclusions: SR patients had higher QOL due to longer retreatment intervals, fewer endoscopic interventions, and lower daily treatment costs.
Trial registration: The study was registered in the Chinese Clinical Trial Registry, number ChiCTR2000037864.
The carbon emissions calculation, decomposition and peak scenario simulation of meat, egg, and milk in China: from a production and consumption perspective
Authors: Zhou Kun , Chen Liu , Wu Jin , Li Hongyao , Wang Huan , Li Jianqiang 
Published: September 2023

Abstract

Characterizing and quantifying livestock carbon emissions helps mitigate temperature rise and potential climate risks. Here, the spatial and temporal characteristics of China’s carbon emissions of meat, egg, and milk are analyzed from the perspective of production and consumption. A driving factor decomposition model of carbon emissions of meat, egg, and milk production and consumption is established using the logarithmic mean Divisia index (LMDI). Using a static scenario analysis and dynamic Monte Carlo simulations (MCS), the evolution trajectory of carbon peak in meat, egg, and milk production and consumption in China during 2021–2030 is analyzed. China’s carbon emissions from meat, egg, and milk production and consumption have risen in 2020, reaching 794.1 and 465.88 Mt, respectively. Moreover, western China has the highest carbon emissions in production (33.84%). For consumption, the carbon emissions are mainly concentrated in the eastern region (42.96%). The key drivers of carbon emissions for this production and consumption are the farmland value and residential income effects, respectively. Conversely, reverse urbanization, agricultural industry structure, and food money purchasing power effects play significant suppressive roles. Under the business-as-usual scenario (BAU), China’s carbon emissions from meat, egg, and milk production and consumption in 2030 will increase by 40.1% and 4.86% from 2020, respectively. The middle low-carbon scenario (Mid-LC) mitigates carbon emission growth by 24.51% and − 5.7%, respectively, for the production and consumption of meat, egg, and milk in 2030 compared to 2020. In the highly low-carbon scenario (Hig-LC), production and consumption will achieve a carbon peak by 2030. Ultimately, this study highlights the importance of reducing carbon emissions from livestock on production and consumption, providing a new perspective for green development in China and other emerging economies.
Comparative Analysis of the Effectiveness of the Budget Funds Use at the Regional Level
Authors: Rechkina E. A. , Terekhov A. M. , Popkova Zh. G. 
Published: September 2023

The purpose of the study.The purpose of the paper is to assess the effectiveness of the use of regional budget expenditures on the example of the budgets of the Nizhny Novgorod and Mur-mansk regions.Materials and methods.General scientific methods are involved: analysis, synthesis, gener-alization, classification; and specifically scientific methods: dynamics analysis, correlation and re-gression analysis, neural network modeling. The information base of the study includes indexes of the execution of the federal budget of the Russian Federation (information from the Federal Treas-ury of the Russian Federation) and regional budgets published in the relevant laws of the regions; statistical data published by Rosstat. The novelty of the research approach lies in the combination of traditional and economic-mathematical methods with the use of the Cobb-Douglas production func-tion. This fact provided an opportunity to assess the impact of budget expenditures on individual factors of production that determine the volume of public product produced. The paper presents a comparative assessment of the effectiveness of budget planning based on normative and program-target methods.Results.It was found that the use of budget funds in the Murmansk region is more effective than in the Nizhny Novgorod region. In this region, starting from 2019, the priority of the task of developing a program-targeted method of budget planning has been reduced, but the region has achieved high efficiency in the use of budget funds due to rational management of budget debt. The budget of the Murmansk Region is characterized by a significant reduction in the debt burden, which reduces the share of public debt servicing costs, and the ratio of the amount of public debt to the expenditures of the regional budget by the end of 2021 approached zero. The study showed that budget expenditures have a significant positive impact on the growth of the capital factor. At the same time, the growth of budget expenditures has a more negative impact on the development of the labor factor. It was found that when using the program-target method, a number of program ex-penditures have a positive impact on the growth of the labor force in the regions, but the degree of such influence is insignificant.Conclusion.In the course of the study, the authors concluded that the efficiency of using budget funds in the Murmansk region is higher than in the Nizhny Novgorod region. This circum-stance indicates a greater influence on the efficiency of the use of budget funds of the quality factor of public debt management in comparison with the influence of the factor of the application of the program-target method of budget planning. The results of the conducted research may be useful to government agencies responsible for planning and budgeting.