bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reported shocks, households' resilience and local food commercialization in Thailand
Authors: Wang Menglan , Do Manh Hung 
Published: January 2023

PurposeThe authors examine the factors affecting households' resilience capacities and the impacts of these capacities on household consumption and crop commercialization.Design/methodology/approachThe authors use panel data of 1,648 households from Thailand collected in three years, 2010, 2013 and 2016. The authors employ an econometric model with an instrumental variable approach to address endogenous issues.FindingsThe study results show that the experience of shocks in previous years positively correlates with households' savings per capita and income diversification. Further, a better absorptive capacity in the form of better savings and a better adaptive capacity in the form of higher income diversification have a significant and positive influence on household expenditure per capita and crop commercialization.Practical implicationsDevelopment policies and programs aiming to improve income, increase savings and provide income diversification opportunities are strongly recommended.Originality/valueThe authors provide empirical evidence on the determinants of resilience strategies and their impacts on local food commercialization from a country in the middle-income group.
Designing a branding model for academic libraries affiliated with the Ministry of Science, Research and Technology in Iran
Authors: Sahli Farzane , Alidousti Sirous , Naghshineh Nader 
Published: January 2023

PurposeThis study identifies factors affecting brand building for academic libraries affiliated with the Ministry of Science, Research and Technology (MSRT) in Iran.Design/methodology/approachThis research applied the grounded theory method based on the three open, axial and selective coding steps (Strauss and Corbin, 1998). The research tool was interviews conducted with 20 experts in librarianship, marketing and branding.FindingsLibrary building architecture, library information resources and services, librarians' branding, marketing activities and library management are the causal conditions affecting brand building. The national economic situation, the digital publishing situation in the country and different characteristics of the new library community are the intervening conditions affecting brand building. The role of other libraries in society in the scientific education of the new generation provides contextual conditions for brand building. The higher education system and the library parent organization play a part in the operative actions/interactions for brand building. The consequences of brand building are brand image development, brand excellence and brand behavioral loyalty for libraries. Library brand identity is also a core category in brand building.Originality/valueFacing steep challenges by emergent services, academic libraries are ill-prepared to meet the needs of the new information society solely with traditional services and functions. Academic libraries are required to rebrand themselves to be more successful at delivering a strong performance within a changing information environment by enhancing their brand image and establishing a more effective relationship with users.
Lean Six Sigma to reduce the acute myocardial infarction mortality rate: a single center study
Authors: Rosa Angelo , Trunfio Teresa Angela , Marolla Giuliano , Costantino Antonietta , Nardella Davide , McDermott Olivia 
Published: January 2023

PurposeCardiovascular diseases are the leading cause of death worldwide. In Italy, acute myocardial infarction (AMI) is a major cause of hospitalization and healthcare costs. AMI is a myocardial necrosis event caused by an unstable ischemic syndrome. The Italian government has defined an indicator called “AMI: 30-day mortality” to assess the quality of the overall care pathway of the heart attacked patient. In order to guarantee high standards, all hospitals had to implement techniques to increase the quality of care pathway. The aim of the paper is to identify the root cause and understand the mortality rate for AMI and redesign the patient management process in order to improve it.Design/methodology/approachA Lean Six Sigma (LSS) approach was used in this study to analyze the patient flow in order to reduce 30-days mortality rate from AMI registered by Complex Operative Unit (COU) of Cardiology of an Italian hospital. Value stream mapping (VSM) and Ishikawa diagrams were implemented as tools of analysis.FindingsProcess improvement using LSS methodology made it possible to reduce the overall times from 115 minutes to 75 minutes, with a reduction of 35%. In addition, the corrective actions such as the activation of a post-discharge outpatient clinic and telephone contacts allowed the 30-day mortality rate to be lowered from 16% before the project to 8% after the project. In this way, the limit value set by the Italian government was reached.Research limitations/implicationsThe limitation of the study is that it is single-centered and was applied to a facility with a limited number of cases.Practical implicationsThe LSS approach has brought significant benefits to the process of managing patients with AMI. Corrective actions such as the activation of an effective shared protocol or telephone interview with checklist can become the gold standard in reducing mortality. The limitation of the study is that it is single-centered and was applied to a facility with a limited number of cases.Originality/valueLSS, applied for the first time to the management of cardiovascular diseases in Italy, is a methodology which has proved to be strategic for the improvement of healthcare process. The simple solutions implemented could serve as a guide for other hospitals to pursue the national AMI mortality target.
Cutaneous manifestations in elderly patients with confirmed coronavirus disease 2019 and the disease outcomes: A systematic review
Authors: Yusharyahya Shannaz Nadia , Japranata Valdi Ven , Jonlean Reganedgary , Legiawati Lili , Astriningrum Rinadewi 
Published: January 2023

AbstractCutaneous manifestations in coronavirus disease 2019 (COVID‐19) patients may possess prognostic value for identifying potentially severe cases. This systematic review investigated whether dermatological features are associated with COVID‐19 outcomes in elderly patients. Literature retrieval was conducted on May 11, 2022, from databases, hand‐searching, and tracing citations. Following selection against eligibility criteria, the remaining records were evaluated utilizing the National Heart, Lung, and Blood Institute Study Quality Assessment Tool or Newcastle–Ottawa Scale. The pooled individual data were subsequently analyzed using the Cochran–Mantel–Haenszel test to calculate the odds ratio (ORs) and confidence intervals (CIs) for the severity and mortality of each skin lesion type. We incorporated 70 articles, including 180 and 117 entries, with information regarding disease severity and mortality. Further analysis revealed that vascular type was the skin lesion most frequently noticed in confirmed COVID‐19 elderly patients (46.2%) and was associated with an increased risk of developing advanced disease (OR 7.32, 95% CI 3.39–15.81) and the ensuing termination (OR 5.73, 95% CI 2.46–13.36). The converse phenomenon was observed in maculopapular type (severity OR 0.27, 95% CI 0.14–0.52; mortality OR 0.10, 95% CI 0.03–0.36). In conclusion, skin manifestations may predict COVID‐19 severity and mortality in the senior group.
Mirror tomography of sparse ocean‐bottom seismometer data: Two‐dimensional synthetic studies
Authors: Liu Bin 
Published: January 2023

AbstractFirst‐arrival travel‐time tomography is frequently used in ocean‐bottom seismometer surveys for estimating subsurface velocity. However, due to a lack of seismometer stations or ray sampling, the tomographic images’ spatial resolution and quality are typically low. Inspired by the multiple imaging of ocean‐bottom seismometer data, in this study, I developed a mirror tomography method to incorporate the travel times of refraction multiples in first‐arrival travel‐time tomography. Specifically, the travel times of refraction multiples were treated as virtual first‐arrival travel times from the mirror positions of the stations. This technique enhances ray coverage and stabilizes the inversion. I confirmed that the travel times of refraction multiples were consistent with the first‐arrival travel times calculated using numerical modelling at the mirror position of the station. Synthetic examples showed that the mirror tomography scheme may enhance ray coverage and model resolution. Mirror tomography may compensate for the uneven distribution of travel‐time picks caused by the loss of the ocean‐bottom seismometer.
Disorder or difference? How clinician‐patient interaction and patient age shape the process and meaning of autism diagnosis
Authors: Turowetz Jason , Wiscons Lucas Z. , Maynard Douglas W. 
Published: January 2023

AbstractThis article follows Blaxter’s foundational call for a sociology of diagnosis that addresses the dual aspects of diagnosis‐as‐category and diagnosis‐as‐process. Drawing on video recordings from an autism clinic, we show how the process of attaching the diagnosis to a child involves interactions between clinicians, parents and children, and that in the course of such interactions, a diagnostic category officially defined in terms of deficits can instead be formulated in terms of valuable social and cognitive differences. More specifically, we show that the child’s age is crucial for how clinicians formulate the diagnosis: with younger children, clinicians treat autism exclusively as a deficit to be remedied, whereas with older children, clinicians may treat autism either as a deficit or as a social‐cognitive difference. Further, because older children are often co‐recipients of diagnostic news, we find that clinicians carefully manage the implications such news may have for their self/identity. Finally, we suggest that (1) the equation of a diagnostic category with dysfunction is achieved in interaction; (2) the meaning of a diagnosis may vary with characteristics of its recipients; and (3) that meaning can be worked up by clinicians and recipients in ways that centre difference rather than deficit.
The role, targets and mechanisms of traditional Chinese medicine in regulating the balance of T helper type 17/regulatory Tcells in rheumatoid arthritis
Authors: Wang Tao , Wang Zhandong , Qi Wenxia , Jiang Ganggang , Wang Gang 
Published: January 2023

AbstractRheumatoid arthritis (RA) is a persistent systemic autoimmune disease, having all the hallmarks of joint swelling, joint tenderness, and progressive joint destruction, with synovitis and pannus formation as the basic pathological changes. T‐lymphocyte infiltration is the key to its pathogenesis. During the growth of RA, the share of regulatory T (Treg) cells decreases, while the percentage of T helper type 17 (Th17) cells increases, giving rise to an imbalance of Th17/Treg cells. Modern medicine has made great advances in the treatment of RA and the selection of available drugs, but there are also the disadvantages of gastrointestinal reaction, high price, and low patient compliance. Therapy of RA remains a problem. Traditional Chinese medicine (TCM) has RA therapy developments, both in experimental research and clinical research, and its advantages of lasting effects and less detrimental reactions and fewer adverse effects are accepted by most patients. Numerous clinical and experimental studies have been performed in TCM on regulating Th17/Treg balance. However, the detailed mechanism of TCM intervention in Th17/Treg equilibrium in preventing and treating RA has not been discovered. In this article, the theory of regulating Th17/Treg cell equilibrium in RA is described from the perspectives of single Chinese medicine, active components of Chinese medicine, Chinese medicine compounds, and other therapies of TCM. It was found that TCM can regulate Th17/Treg cell balance and inhibit immunoreaction by intervening in cytokines, transcription factors, and signal pathways. It enables us to comprehensively and deeply understand the mechanism of TCM intervening in Th17/Treg balance in RA; provides direction for clinical therapy of RA; and offers new thoughts for understanding the pathogenesis of RA.
Effectiveness and safety of generic tofacitinib in spondyloarthritis: A real‐world retrospective analysis from India
Authors: Phatak Sanat , Khenat Aditya , Malandkar Mansi , Amin Sanjiv 
Published: January 2023

AbstractBackgroundClinical trial evidence demonstrates the efficacy of tofacitinib in ankylosing spondylitis and psoriatic arthritis (PsA). Real‐world data from spondyloarthritis (SpA) patients are scarce; there are few reports of its effectiveness and safety from low‐ to middle‐income countries like India, despite its widespread usage.MethodsThis was a retrospective analysis of clinical and laboratory records of 100 patients with SpA prescribed generic tofacitinib from a single center in Mumbai, India. Disease activity was measured using the Ankylosing Spondylitis Disease Activity Score C‐Reactive Protein (ASDAS‐CRP) in all patients, along with disease‐specific outcome measures in the subgroups. We used paired t test for response to tofacitinib. We compared Δ ASDAS‐CRP in patients with active peripheral arthritis and in patients without. We defined clinical tofacitinib failure as the physician's decision to change or add a disease‐modifying antirheumatic drug (DMARD), and performed logistic regression to identify factors associated with tofacitinib failure.ResultsAmong 100 patients (71 male, median age 42.5 years), 57 had axial SpA, 10 had peripheral SpA, 4 had inflammatory bowel disease‐SpA and 29 had PsA. One‐third had received biologic DMARDs previously. Patients received tofacitinib for a median of 192 days. There was a significant improvement in ASDAS‐CRP in all types of SpA. Patients with active peripheral arthritis had a significantly greater fall in ASDAS‐CRP. There were no serious adverse events, 19 patients had mild COVID‐19; no patient had tuberculosis. Ten patients had tofacitinib failure; no baseline parameter could predict failure.InterpretationIn the real‐world setting, generic tofacitinib showed good effectiveness and tolerable safety profile in Indian patients with SpA.
Circ_0043256 upregulates KLF2 expression by absorbing miR‐1206 to suppress the tumorigenesis of lung cancer
Authors: Zhou Ying , Liu Hongliu , Wang Rui , Zhang Mingtao 
Published: January 2023

AbstractBackgroundCircular RNAs (circRNAs) have been reported to play roles in lung cancer development. The purpose of this work was to explore the function and mechanism of circ_0043256 in lung cancer tumorigenesis.MethodsQuantitative real‐time polymerase chain reaction (qRT‐PCR) and western blot were used for the detection of the levels of genes and proteins. Cell growth, angiogenesis ability, migration, and invasion were analyzed by using 5‐ethynyl‐2′‐deoxyuridine (EdU) assay, flow cytometry, tube formation assay, transwell assay, and murine xenograft model, respectively. The target between miR‐1206 and circ_0043256 or Krüppel‐like factor 2 (KLF2) was verified by dual‐luciferase reporter assay.ResultsCirc_0043256 was a stable circRNA, which was found to be decreased in lung cancer tissues and cells. Functionally, forced expression of circ_0043256 suppressed lung cancer cell growth, angiopoiesis, migration, and invasion. Mechanistically, circ_0043256 directly bound to miR‐1206 and miR‐1206 targeted KLF2, circ_0043256 could regulate KLF2 expression via absorbing miR‐1206. Rescue assay showed that miR‐1206 overexpression reversed the anticancer effects of circ_0043256 on lung cancer cells. Moreover, inhibition of miR‐1206 could suppress the malignant phenotypes of lung cancer cells, which was attenuated by KLF2 knockdown. Pre‐clinically, lentivirus‐mediated circ_0043256 overexpression impeded lung cancer growth in nude mice.ConclusionForced expression of circ_0043256 could impede the tumorigenesis of lung cancer via miR‐1206/KLF2 axis, indicating a potential therapeutic approach for lung cancer.
Analyst workload and information production: Evidence from IPO assignments
Authors: Pisciotta Kevin 
Published: January 2023

AbstractI examine how changes in analysts' workloads affect their information production. Examining determinants of analysts' information production is important because analyst research affects stock prices and capital allocation decisions. Using periods when analysts work on IPOs to proxy for shocks to their workloads, I predict and find that the accuracy, quantity, and timeliness of analysts' forecasts for non‐IPO firms decline when they are working on IPOs, and they herd closer to the consensus. The reductions in research quality are larger for less experienced analysts, larger IPOs, and less important portfolio firms. Last, I predict and find that information asymmetry increases for non‐IPO firms covered by analysts who are working on IPOs, consistent with analysts' reduction in research quality during IPO assignments negatively affecting the information environment of non‐IPO firms. In sum, I provide the first evidence that analysts' work on IPO deals imposes negative externalities on both the quality of research they produce for the non‐IPO firms they cover and the information environments of these firms, highlighting at least one reason why analyst workload is important to firms and investors.
The predictive validity of the Alcohol, Smoking and Substance Involvement Screening Test (ASSIST) for moderate‐ to high‐risk cannabis, methamphetamine and opioid use after release from prison
Authors: Cumming Craig , Kinner Stuart A. , McKetin Rebecca , Young Jesse T. , Li Ian , Preen David B. 
Published: January 2023

AbstractBackground and aimsIllicit substance use is common among people entering prisons, as is returning to substance use after release from prison. We aimed to assess the predictive validity of the Alcohol, Smoking and Substance Involvement Screening Test (ASSIST) for returning to substance use after release from prison.DesignA longitudinal design with baseline survey conducted between 2008 and 2010 in the 6 weeks before expected prison release and up to three follow‐up surveys in the 6 months after release.SettingPrisons in Queensland, Australia.ParticipantsA total of 1054 adults within 6 weeks of expected release from prison.MeasurementsThe ASSIST was used to assess problematic use of cannabis, methamphetamine, heroin and other non‐prescribed opioids in the 3 months before incarceration. Post‐incarceration substance use was measured at 1, 3 and 6 months after release. We calculated the area under the receiver operating characteristic curve (AUROC) and the optimal ASSIST cut‐off score for each substance, using Youden’s index (J).FindingsForty‐one per cent (n = 434) of the cohort reported any substance use during follow‐up: 33% (n = 344) used cannabis, 20% (n = 209) methamphetamine, 10% (n = 109) heroin and 9% (n = 97) illicit other opioids. The optimal ASSIST cut‐off score was ≥ 4 for heroin, methamphetamine and cannabis and ≥ 1 for other opioids. Using these cut‐offs, the AUROC was highest for heroin in predicting both any use (AUROC = 0.82) and weekly use (AUROC = 0.88) in the past 4 weeks. AUROCs for other drugs ranged from 0.73 to 0.79.ConclusionsThe ASSIST shows promise as an accurate and potentially scalable tool that may be useful for predicting a return to substance use after release from prison and could inform service delivery. The substantial rates of returning to substance use after release from prison suggest that prison serves to interrupt rather than cease substance use.
When teams disagree: Investigating the incidence and causes of dissent occurring in cancer multidisciplinary team meetings
Authors: Chambers Anthony J. , Enoch Jade F. , Wong Jasmine , Spigelman Allan 
Published: January 2023

AbstractAimMultidisciplinary teams (MDT) are commonly involved in the care of patients with cancer. How frequently dissent occurs within MDT has not been studied. This study aimed to determine how frequently dissent was documented in cancer MDT meetings at our institution, the reasons for this, and the opinions of MDT members on how dissent should be documented and communicated.MethodsA retrospective review of records from cancer MDT meetings at our institution from 2016 to 2020 was performed to identify cases where dissent was documented and the reasons for this. MDT members were invited to complete an online survey assessing their perceptions of how frequently dissent occurred, how comfortable they felt voicing dissenting opinions, and their opinions on how dissent should be documented and communicated.ResultsDissent was recorded in 30 of 7737 MDT case discussions (0.39%). The incidence of dissent varied from 0 to 1.2% between cancer streams. The most common reason for dissent involved the role of surgery. 27% of survey respondents felt either very or somewhat uncomfortable voicing dissenting opinions. Only 3% felt that dissent should not be documented, and none that it should not be communicated in some way, although there were wide ranging of views on how this should occur.ConclusionDissent was rarely documented within cancer MDT meetings at our institution, likely due to underreporting. Measuring the incidence of dissent within an MDT may be a useful performance metric. MDT should develop policies for how dissent should be managed, documented, and communicated.
Hsa_circ_0001326 inhibited the proliferation, migration, and invasion of trophoblast cells via miR‐145‐5p/TGFB2 axis
Authors: Song Meiyu , Xu Peng , Wang Li , Liu Jie , Hou Xiaofei 
Published: January 2023

AbstractProblemPreeclampsia (PE) is an obstetric disease involving multiple systems, which account for maternal and fetal complications and increased mortality. Circular RNAs (circRNAs) were recently deemed to associate with the pathogenesis of PE. This study aims to clarify the correlation between circRNA hsa_circ_0001326 and PE and explore its biological function in PE.Method of studyThe expression of hsa_circ_0001326 in PE placentas was detected by real‐time quantitative PCR (qRT‐PCR). After overexpressing or inhibiting hsa_circ_0001326 in trophoblast cells, the cell growth, migration, and invasion were evaluated by Cell Counting Kit‐8 (CCK‐8) and transwell assays. Western blot assay was applied to detect the epithelial‐mesenchymal transition (EMT) proteins, E‐cadherin and Vimentin. Furthermore, a dual‐luciferase reporter assay was applied to verify the binding sites of hsa_circ_0001326, miR‐145‐5p, and transforming growth factor beta 2 (TGFB2).ResultsHsa_circ_0001326 was found to be higher expressed in PE placentas than in normal placentas. Furthermore, hsa_circ_0001326 played a negative regulating role in trophoblast cell viability, migration, and invasion. Overexpression of hsa_circ_0001326 inhibited the viability, migration, and invasion of trophoblast cells, while inhibition of hsa_circ_0001326 showed opposite effects. Mechanistically, hsa_circ_0001326 sponged miR‐145‐5p to elevate TGFB2 expression in trophoblast cells.ConclusionThis study provided evidence that the up‐regulated hsa_circ_0001326 in PE restrained trophoblast cells proliferation, migration, and invasion by sponging miR‐145‐5p to elevate TGFB2 expression. Our results might provide a novel insight into the role of hsa_circ_0001326 in the pathogenesis of PE.