bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring procedure duration and risk for serious adverse events during congenital cardiac catheterization
Authors: Yeh Mary J , Lydon Elizabeth , Gauvreau Kimberlee , Jenkins Kathy J , Slater David , Bergersen Lisa 
Published: January 2023

ObjectivesWhile procedure length is considered an important metric for cardiothoracic surgical procedures, the relationship between procedure length and adverse events (AEs) in congenital cardiac catheterizations has little published data available. Furthermore, most existing congenital cardiac catheterization risk prediction models are built on logistic regression models. This study aimed to characterize the relationship between case length and AE occurrence in congenital cardiac catheterization while adjusting for known risk factors and to investigate the potential role of non-linear analysis in risk modeling.DesignAge, case type, and procedure duration were evaluated for relationships with the primary outcome using logistic regression. Non-linearity of the associations with continuous risk factors was assessed using restricted cubic spline transformations.Setting and participantsAll diagnostic and interventional congenital cardiac catheterization cases performed at Boston Children’s Hospital between January 1, 2014 and October 31, 2019 were analyzed.Main outcome measureThe primary outcome was defined as the occurrence of any clinically significant (level 3/4/5) AE.ResultsA total of 7011 catheterization cases met inclusion criteria, with interventional procedures accounting for 68% of cases. Median case duration was 97 min. A multivariable model including age, procedure type, and case duration showed a significant relationship between case duration and AE occurrence (OR 1.07 per 10 min increase, 95% CI 1.06 to 1.09, p<0.001).ConclusionsThis study demonstrated the importance of procedure duration as a potential frontier for procedure risk management. Better understanding of the role of procedure duration in cardiac catheterizations may provide opportunities for quality improvement in patient safety and resource planning.
Latent profiles of biological dysregulation and risk of mortality: time-to-event analysis using the Midlife in the US longitudinal study
Authors: Carbone Jason T , Holzer Katherine J , Clift Jennifer , Fu Qiang 
Published: January 2023

BackgroundThere is a well-established relationship between high allostatic load (AL) and increased risk of mortality. This study expands on the literature by combined latent profile analysis (LPA) with survival data analysis techniques to assess the degree to which AL status is associated with time to death.MethodsLPA was employed to identify underlying classes of biological dysregulation among a sample of 815 participants from the Midlife in the US study. Sex-stratified Cox proportional hazards regression models were used to estimate the association between class of biological dysregulation and time to death while controlling for sociodemographic covariates.ResultsThe LPA resulted in three classes: low dysregulation, immunometabolic dysregulation and parasympathetic reactivity. Women in the immunometabolic dysregulation group had more than three times the risk of death as compared with women in the low dysregulation group (HR=3.25, 95% CI: 1.47 to 7.07), but that there was not a statistically significant difference between the parasympathetic reactivity group and the low dysregulation group (HR=1.80, 95% CI: 0.62 to 5.23). For men, the risk of death for those in the immunometabolic dysregulation (HR=1.79, 95% CI: 0.88 to 3.65) and parasympathetic reactivity (HR=0.90, 95% CI: 0.34 to 3.65) groups did not differ from the low dysregulation group.ConclusionThe findings are consistent with the previous research that demonstrates increased AL as a risk factor for mortality. Specifically, in women, that increased risk may be associated with immunometabolic dysregulation and not simply a generalised measure of cumulative risk as is typically employed in AL research.
Novel role of microphthalmia-associated transcription factor in modulating the differentiation and immunosuppressive functions of myeloid-derived suppressor cells
Authors: Lee Aram , Park Haesun , Lim Soyoung , Lim Jihyun , Koh Jaemoon , Jeon Yoon Kyung , Yang Young , Lee Myeong-Sok , Lim Jong-Seok 
Published: January 2023

BackgroundMicrophthalmia-associated transcription factor (MITF) is a master regulator of melanogenesis and is mainly expressed in melanoma cells. MITF has also been reported to be expressed in non-pigmented cells, such as osteoclasts, mast cells, and B cells. However, the roles of MITF in immunosuppressive myeloid cells, including myeloid-derived suppressor cells (MDSCs), remain unclear. Here, we investigated the role of MITF in the differentiation process of MDSCs during tumor development.MethodsIn vitro-generated murine MDSCs and primary MDSCs from breast cancer-bearing mice or lung carcinoma-bearing mice were used to determine the expression level of MITF and the activity of MDSCs. Additionally, we investigated whether in vivo tumor growth can be differentially regulated by coinjection of MDSCs in which MITF expression is modulated by small molecules. Furthermore, the number of MITF+monocytic (MO)-MDSCs was examined in human tumor tissues or tumor-free lymph nodes by immunohistochemistry (IHC).ResultsThe expression of MITF was strongly increased in MO-MDSCs from tumors of breast cancer-bearing mice compared with polymorphonuclear MDSCs. We found that MITF expression in MDSCs was markedly induced in the tumor microenvironment (TME) and related to the functional activity of MDSCs. MITF overexpression in myeloid cells increased the expression of MDSC activity markers and effectively inhibited T-cell proliferation compared with those of control MDSCs, whereas shRNA-mediated knockdown of MITF in myeloid cells altered the immunosuppressive function of MDSCs. Modulation of MITF expression by small molecules affected the differentiation and immunosuppressive function of MDSCs. While increased MITF expression in MDSCs promoted breast cancer progression and CD4+or CD8+T-cell dysfunction, decreased MITF expression in MDSCs suppressed tumor progression and enhanced T-cell activation. Furthermore, IHC staining of human tumor tissues revealed that MITF+MO-MDSCs are more frequently observed in tumor tissues than in tumor-free draining lymph nodes obtained from patients with cancer.ConclusionsOur results indicate that MITF regulates the differentiation and function of MDSCs and can be a novel therapeutic target for modulating MDSC activity in immunosuppressive TMEs.
Profiling of the genetic features of Chinese patients with gastric cancer with HRD germline mutations in a large-scale retrospective study
Authors: Zhang Chenghai , Zhu Dandan , Qu Yurong , Shi Min , Ma Jingjiao , Peng Yebo , Zhu Bowen , Tao Houquan , Ma Tonghui , Hou TieYing 
Published: January 2023

BackgroundApproximately 10% of gastric cancers (GCs) are associated with strong familial clustering and can be attributed to genetic predisposition. Homologous recombination deficiency (HRD) leads to genomic instability and accumulation of genetic variations, playing an important role in the development and progression of cancer. We aimed to delineate the germline mutation characteristics of patients with HRD-mut GC in Chinese.MethodsWe retrospectively reviewed the genomic sequencing data of 1135 patients with Chinese GC. Patients harbouring at least one loss of function (LoF) germline mutations inBRCA1,BRCA2,ATM,PALB2,BRIP1,CHEK1,CHEK2,FANCAandFANCLwere selected for analysis.Results89 patients were identified with LoF germline mutations of HRD gene. Germline mutations occurred most commonly inATM(30.33%), followed byBRIP1(17.98%),BRCA2(14.61%),BRCA1(12.36%),FANCA(10.11%),PALB2(10.11%),FANCL(6.74%),CHEK1(3.37%) andCHEK2(3.37%). 14 out of 89 patients with HRD-mut harboured double mutations in HRD and MMR genes, with the median age of 51.5 years. The decreasing median age would be attributed to five patients with HRD+MMR double-muts harbouring mutations in both HRD and MMR genes. The median age of onset of patients with HRD+MMR double-muts is 47, which is significantly earlier than that of Chinese patients with GC (p=0.0235).ConclusionOur data suggest that carrying both HRD and MMR gene LoF germline mutations may cause early-onset GC. Germline mutations in the HRD gene should be of concern in the study of hereditary GC.
Neuropsychiatric symptoms in genetic frontotemporal dementia: developing a new module for Clinical Rating Scales
Authors: Samra Kiran , Macdougall Amy , Peakman Georgia , Bouzigues Arabella , Bocchetta Martina , Cash David M , Greaves Caroline V , Convery Rhian S , van Swieten John C , Jiskoot Lize C , Seelaar Harro , Moreno Fermin , Sánchez-Valle Raquel , Laforce Robert , Graff Caroline , Masellis Mario , Tartaglia Maria Carmela , Rowe James B , Borroni Barbara , Finger Elizabeth , Synofzik Matthis , Galimberti Daniela , Vandenberghe Rik , de Mendonca Alexandre , Butler Christopher R , Gerhard Alexander , Ducharme Simon , Le Ber Isabelle , Tiraboschi Pietro , Santana Isabel , Pasquier Florence , Levin Johannes , Otto Markus , Sorbi Sandro , Rohrer Jonathan D , Russell Lucy L 
Published: January 2023

BackgroundCurrent clinical rating scales in frontotemporal dementia (FTD) often do not incorporate neuropsychiatric features and may therefore inadequately measure disease stage.Methods832 participants from the Genetic FTD Initiative (GENFI) were recruited: 522 mutation carriers and 310 mutation-negative controls. The standardised GENFI clinical questionnaire assessed the frequency and severity of 14 neuropsychiatric symptoms: visual, auditory, and tactile hallucinations, delusions, depression, anxiety, irritability/lability, agitation/aggression, euphoria/elation, aberrant motor behaviour, hypersexuality, hyperreligiosity, impaired sleep, and altered sense of humour. A principal component analysis (PCA) was performed to identify key groupings of neuropsychiatric and behavioural items in order to create a new neuropsychiatric module that could be used as an addition to the Clinical Dementia Rating (CDR) plus National Alzheimer’s Coordinating Center Behaviour and Language Domains (NACC FTLD) rating scale.ResultsOverall, 46.4% of mutation carriers had neuropsychiatric symptoms (51.6%C9orf72, 40.8%GRN, 46.6%MAPT) compared with 24.5% of controls. Anxiety and depression were the most common in all genetic groups but fluctuated longitudinally and loaded separately in the PCA. Hallucinations and delusions loaded together, with the remaining neuropsychiatric symptoms loading with the core behavioural features of FTD. These results suggest using a single ‘psychosis’ neuropsychiatric module consisting of hallucinations and delusions. Adding this to the CDR plus NACC FTLD, called the CDR plus NACC FTLD-N, leads to a number of participants being scored more severely, including those who were previously considered asymptomatic now being scored as prodromal.ConclusionsNeuropsychiatric symptoms occur in mutation carriers at all disease stages across all three genetic groups. However, only psychosis features provided additional staging benefit to the CDR plus NACC FTLD. Inclusion of these features brings us closer to optimising the rating scale for use in trials.
Daratumumab for the treatment of refractory ANCA-associated vasculitis
Authors: Ostendorf Lennard , Burns Marie , Wagner Dimitrios Laurin , Enghard Philipp , Amann Kerstin , Mei Henrik , Eckardt Kai-Uwe , Seelow Evelyn , Schreiber Adrian 
Published: January 2023

ObjectiveTreatment-refractory antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a life-threatening condition without evidence-based treatment options. One emerging treatment option for several antibody-mediated autoimmune diseases is the anti-CD38 antibody daratumumab, which depletes autoantibody-secreting plasma cells.MethodsWe treated two patients with severe life-threatening AAV with renal and pulmonary manifestation despite induction therapy with rituximab and cyclophosphamide with four to eight doses of 1800 mg daratumumab. We followed clinical and immunological responses.ResultsThe first patient with myeloperoxidase-ANCA-positive microscopic polyangiitis had resolution of pneumonitis and pleuritis and stabilisation of kidney function after daratumumab. The second patient with proteinase 3-ANCA-positive granulomatosis with polyangiitis, diffuse alveolar haemorrhage necessitating extracorporeal membrane oxygenation (ECMO) and acute kidney failure, requiring kidney replacement therapy, was weaned off ECMO, mechanical ventilation and dialysis and discharged home after daratumumab. Clinical improvement was paralleled by a strong reduction in serum ANCA levels as well as total IgG, indicating depletion of plasma cells. Apart from the depletion of CD38+natural killer cells, blood leucocyte levels were not notably influenced by daratumumab. Only mild adverse events, such as hypogammaglobulinaemia and an upper respiratory tract infection occurred.ConclusionDaratumumab was safe and effective in inducing remission in two patients with severe treatment-refractory AAV, warranting prospective clinical trials to establish safety and efficacy.
Cochlear Theta Activity Oscillates in Phase Opposition during Interaural Attention
Authors: Köhler Moritz Herbert Albrecht , Weisz Nathan 
Published: January 2023

Abstract
It is widely established that sensory perception is a rhythmic process as opposed to a continuous one. In the context of auditory perception, this effect is only established on a cortical and behavioral level. Yet, the unique architecture of the auditory sensory system allows its primary sensory cortex to modulate the processes of its sensory receptors at the cochlear level. Previously, we could demonstrate the existence of a genuine cochlear theta (∼6-Hz) rhythm that is modulated in amplitude by intermodal selective attention. As the study's paradigm was not suited to assess attentional effects on the oscillatory phase of cochlear activity, the question of whether attention can also affect the temporal organization of the cochlea's ongoing activity remained open. The present study utilizes an interaural attention paradigm to investigate ongoing otoacoustic activity during a stimulus-free cue–target interval and an omission period of the auditory target in humans. We were able to replicate the existence of the cochlear theta rhythm. Importantly, we found significant phase opposition between the two ears and attention conditions of anticipatory as well as cochlear oscillatory activity during target presentation. Yet, the amplitude was unaffected by interaural attention. These results are the first to demonstrate that intermodal and interaural attention deploy different aspects of excitation and inhibition at the first level of auditory processing. Whereas intermodal attention modulates the level of cochlear activity, interaural attention modulates the timing.
What Is (Insurgent) Universality?
Authors: Tomba Massimiliano 
Published: January 2023

Abstract
In my response to Harry Harootunian, Aldo Beretta, Rebecca Fritzl, Niklas Plaetzer, and Vanita Seth, I discuss some of the terms that constitute the theoretical plot of my book: insurgent, universality, temporality. I also discuss the methodology of my work and the difference between radical democracy, insurgent democracy, and what I call the democratic excess. Eventually, in my response to Seth, I show how the work method of Insurgent Universality is maximally distant from any ontological discourse.
Emulating Rainfall-Runoff-Inundation Model using Deep Neural Network with Dimensionality Reduction
Authors: Momoi Masahiro , Kotsuki Shunji , Kikuchi Ryota , Watanabe Satoshi , Yamada Masafumi , Abe Shiori 
Published: January 2023

Abstract
Predicting the spatial distribution of maximum inundation depth (depth-MAP) is important for the mitigation of hydrological disasters induced by extreme precipitation. However, physics-based rainfall-runoff-inundation (RRI) models, which are used operationally to predict hydrological disasters in Japan, require massive computational resources for numerical simulations. Here, we aimed at developing a computationally inexpensive deep learning model (Rain2Depth) that emulates an RRI model. Our study focused on the Omono River (Akita Prefecture, Japan) and predicted the depth-MAP from spatial and temporal rainfall data for individual events.
Rain2Depth was developed based on a convolutional neural network (CNN), and predicts depth-MAP from 7-day successive hourly rainfall at 13 rain gauge stations in the basin. For training the Rain2Depth, we simulated the depth-MAP by the RRI model forced by 50-ensembles of 30-year data from large-ensemble weather/climate predictions. Instead of using the input and output data directly, we extracted important features from input and output data with two dimensionality reduction techniques (principal component analysis (PCA) and the CNN approach) prior to training the network. This dimensionality reduction aimed to avoid overfitting caused by insufficient training data. The nonlinear CNN approach was superior to the linear PCA for extracting features. Finally, Rain2Depth was architected by connecting the extracted features between input and output data through a neural network.
Rain2Depth-based predictions were more accurate than predictions from our previous model (K20), which used ensemble learning of multiple regularized regressions for a specific station. Whereas the K20 can predict maximum inundation depth only at stations, our study achieved depth-MAP prediction by training only the single model Rain2Depth.
Exploring Influences of Shallow Topography in Stable Boundary Layers: The SAVANT Field Campaign
Authors: Hiscox April , Bhimireddy Sudheer , Wang Junming , Kristovich David A. R. , Sun Jielun , Patton Edward G. , Oncley Steve P. , Brown William O. J. 
Published: January 2023

Abstract
Stable boundary layers are still a relatively problematic component of atmospheric modeling, despite their frequent occurrence. While general agreement exists that Monin–Obukhov similarity is not applicable in the stable boundary layer (SBL) due to the nonhomogeneous, nonstationary flow, no universal organizing theory for the surface SBL has been presented. The Stable Atmospheric Variability and Transport (SAVANT) field campaign took place in the fall of 2018 to explore under what conditions shallow drainage flow is generated. The campaign took place in an agricultural setting and covered the period of both pre- and postharvest, allowing for not only a basic exploration of the boundary layer but also a robust dataset for applied agricultural understanding of aerosol dispersion and impacts of changes in surface cover on drainage flows. This article provides a description of the field campaign. Examples of publicly available data products are presented, as well as examples of shallow drainage flow and corresponding lidar measurements of dispersion. Additionally, the field campaign was used to provide educational opportunities for students from several disciplines, and the outcomes of these joint educational ventures are discussed as models for future collaborations.
Interannual Variability of the Wintertime Asian–Bering–North American Teleconnection Linked to Eurasian Snow Cover and Maritime Continent Sea Surface Temperature
Authors: Zhong Wogu , Wu Zhiwei 
Published: January 2023

Abstract
Recent studies propose that the Asian–Bering–North American (ABNA) teleconnection is a distinct atmospheric pattern that is related to Eurasian and North American winter climate besides the Pacific–North America (PNA) pattern, while its origin remains elusive. This study investigates the interannual variability of the ABNA during the past 42 winters (1979–2020) and the associated prior surface boundary forcings. The ABNA explains coherent surface air temperature changes in northern Asia, eastern Siberia–Alaska, and eastern North America, even after removing the impacts of the PNA, the Arctic Oscillation, the North Atlantic Oscillation, and the North Pacific Oscillation. Surface boundary conditions linked to the ABNA could be traced back to a Eurasian snow cover dipole pattern (ESCDP) and a Maritime Continent sea surface temperature anomaly (MCSST) in November. The ESCDP leads to a displacement of the Arctic stratospheric polar vortex via troposphere–stratosphere coupling. The anomalous polar vortex propagates downward in the following winter and generates the tropospheric ABNA pattern. The MCSST induces a diabatic heating anomaly, which is associated with a tropical western Pacific precipitation anomaly (TWPP) in winter. The TWPP excites a poleward Rossby wave train that propagates across the North Pacific and directly strengthens the ABNA. The above physical processes can be well reproduced by a linear baroclinic model (LBM). Based on the ESCDP and MCSST predictors, an empirical model is established and shows a promising prediction skill of the ABNA during the hindcast period. This can provide a useful strategy for seasonal prediction of winter climate in the Northern Hemisphere extratropics.

Significance Statement
Extreme cold events have influenced both Asian and North American continents during the past decades, causing huge socioeconomic impacts. The Asian–Bering–North American teleconnection is found to be responsible for coherent changes of winter climate in these two continents besides the Pacific–North America pattern. Our results indicate that Eurasian snow cover and the Maritime Continent sea surface temperature are important sources of predictability for the Asian–Bering–North American teleconnection, and can be used to predict coherent and cross-continent variations of winter surface air temperature. We propose that the Asian–Bering–North American teleconnection and these two predictors should be included in operational monitoring and prediction systems, helping to improve the prediction skill of winter climate in the Northern Hemisphere continents.
Past to Future Drylands in China: A Multimodel Analysis Using CMIP6 Simulations
Authors: Shi Jiawen , Tian Zhiping , Lang Xianmei , Jiang Dabang 
Published: January 2023

Abstract
Using the multimodel simulations from phase 6 of the Coupled Model Intercomparison Project (CMIP6), we investigate the aridity changes in China and the associated mechanisms during the three geological periods of the Last Interglacial (LIG), Last Glacial Maximum (LGM), and mid-Holocene (MH), as well as the three future scenarios of the shared socioeconomic pathways of SSP1-2.6, SSP2-4.5, and SSP5-8.5. The aridity index is used to measure terrestrial moisture, which combines the effects of both precipitation and potential evapotranspiration (PET), with the latter representing the amount of water consumed by the atmosphere. The results show that relative to the preindustrial period, the total dryland area in China varies by −15%, 6%, and −13% during the LIG, LGM, and MH, respectively, and slightly varies in the three future scenarios. Over China, LGM dryland expansion and future dryland contraction are mainly attributed to precipitation changes, MH dryland contraction is mainly caused by PET changes, and LIG dryland contraction is comparably caused by PET and precipitation changes. For the LGM and three future scenarios, temperature is the leading factor of PET changes, while during the MH and LIG, the change in relative humidity is the main factor. In comparison, the simulated aridity changes in China are generally consistent with the reconstructed moisture changes for the three past periods, although uncertainties exist in reconstructions during the LGM and MH.