bluuebunny/crossref_metadata_2025_split huggingface dataset:
Natural Oncolysis of Enterovirus 71 in Antitumor Therapy of Colorectal Cancer
Authors: Ruan Zhihui , Chi Jiangyang , Kong Yue , Li Chengcheng , Ruan Xiaolan , Zhou Xing , Chen Yanxi , Li Yongkui , Luo Zhen 
Published: May 2023

AbstractColorectal cancer (CRC) is an intestinal malignant tumor with high morbidity and mortality worldwide. Inoperability or resistanance to radiation and chemotherapy occur in the conventional treatments against CRC. Oncolytic viruses (OVs) are one kind of virus that selectively infects and lyses cancer cells, which is considered to be a new anticancer therapy with biological and immune‐based approaches. Enterovirus 71 (EV71), belonging to the enterovirus genus in the family Picornaviridae, is a single positive‐stranded RNA virus. EV71 is transmitted in a fetal‐oral route and infects gastrointestinal tract in infants. Here, EV71 is exploited to be a novel oncolytic virus in colorectal cancer. It is revealed that EV71 infection can selectively cause colorectal cancer cells cytotoxicity but not primary intestinal epithelial cells. Consistently, EV71 injection significantly inhibits tumor growth in nude mice xenografted colorectal cancer cells. In detail, EV71 infects colorectal cancer cells to repress the expression of Ki67 and B‐cell leukemia 2 (Bcl‐2) leading to the inhibition of cell proliferation, while activating the cleavage of poly‐adenosine diphosphatase‐ribose polymerase and Caspase‐3 protein resulting in the promotion of cell apoptosis. The findings demonstrate the oncolytic feature of EV71 in CRC treatment and may provide a potential clue for clinical anticancer therapy.
Extrusion‐Based 3D Bioprinting of Adhesive Tissue Engineering Scaffolds Using Hybrid Functionalized Hydrogel Bioinks
Authors: Chen Shuai , Tomov Martin L. , Ning Liqun , Gil Carmen J. , Hwang Boeun , Bauser‐Heaton Holly , Chen Haifeng , Serpooshan Vahid 
Published: May 2023

AbstractAdhesive tissue engineering scaffolds (ATESs) have emerged as an innovative alternative means, replacing sutures and bioglues, to secure the implants onto target tissues. Relying on their intrinsic tissue adhesion characteristics, ATES systems enable minimally invasive delivery of various scaffolds. This study investigates development of the first class of 3D bioprinted ATES constructs using functionalized hydrogel bioinks. Two ATES delivery strategies, in situ printing onto the adherend versus printing and then transferring to the target surface, are tested using two bioprinting methods, embedded versus air printing. Dopamine‐modified methacrylated hyaluronic acid (HAMA‐Dopa) and gelatin methacrylate (GelMA) are used as the main bioink components, enabling fabrication of scaffolds with enhanced adhesion and crosslinking properties. Results demonstrate that dopamine modification improved adhesive properties of the HAMA‐Dopa/GelMA constructs under various loading conditions, while maintaining their structural fidelity, stability, mechanical properties, and biocompatibility. While directly printing onto the adherend yields superior adhesive strength, embedded printing followed by transfer to the target tissue demonstrates greater potential for translational applications. Together, these results demonstrate the potential of bioprinted ATESs as off‐the‐shelf medical devices for diverse biomedical applications.
Facile Synthesis of Highly Stretchable, Tough, and Photodegradable Hydrogels
Authors: Fonseca Rita G. , Kuster Aline , Fernandes Pedro P. , Tavakoli Mahmoud , Pereira Patrícia , Fernandes José R. , De Bon Francesco , Serra Arménio C. , Fonseca Ana C. , Coelho Jorge F. J. 
Published: May 2023

AbstractRecently, highly stretchable and tough hydrogels that are photodegradable on‐demand have been reported. Unfortunately, the preparation procedure is complex due to the hydrophobic nature of the photocrosslinkers. Herein, a simple method is reported to prepare photodegradable double‐network (DN) hydrogels that exhibit high stretchability, toughness, and biocompatibility. Hydrophilic ortho‐nitrobenzyl (ONB) crosslinkers incorporating different poly(ethylene glycol) (PEG) backbones (600, 1000, and 2000 g mol−1) are synthesized. These photodegradable DN hydrogels are prepared by the irreversible crosslinking of chains by using such ONB crosslinkers, and the reversible ionic crosslinking between sodium alginate and divalent cations (Ca2+). Remarkable mechanical properties are obtained by combining ionic and covalent crosslinking and their synergistic effect, and by reducing the length of the PEG backbone. The rapid on‐demand degradation of these hydrogels is also demonstrated by using cytocompatible light wavelength (λ = 365 nm) that degrades the photosensitive ONB units. The authors have successfully used these hydrogels as skin‐worn sensors for monitoring human respiration and physical activities. A combination of excellent mechanical properties, facile fabrication, and on‐demand degradation holds promise for their application as the next generation of substrates or active sensors eco‐friendly for bioelectronics, biosensors, wearable computing, and stretchable electronics.
Millimeter‐Thick Liquid Crystalline Elastomer Actuators Prepared by‐Surface‐Enforced Alignment
Authors: McCracken Joselle M. , Hoang Jonathan D. , Herman Jeremy A. , Lynch Kelsey M. , White Timothy J. 
Published: May 2023

AbstractLiquid crystalline elastomers (LCE) are thermally cyclable, compliant actuators with compelling mechanical properties. The large and programmable deformation of LCE has led to numerous functional examinations spanning optics, medical devices, and robotics. A well‐established method to prepare complex LCE actuators is to utilize surface‐enforced photoalignment. Herein, a facile and scalable approach is reported to circumvent the physical limits of surface‐enforced alignment (e.g., samples that are 50 µm or less) to amplify the achievable force output in LCE. Applying an approach termed direct layering, the thermomechanical response of LCE elements prepared with +1 disclination patterns in a range of compositions and thicknesses is contrasted. The design and preparation of +1 disclination patterns and arrays is explored to assess the contribution of sample geometry and overlap to deformation and force output. The methodology detailed in this contribution allows for the preparation of elements ≈1 mm in thickness that are capable of actuating large objects. Furthermore, the fabrication of these elements uniquely enables the realization of mechanical instabilities to hasten the actuation rate in response to thermal change and to enable leaping.
Emergence and Relaxation of an e–h Quantum Liquid Phase in Photoexcited MoS2 Nanoparticles at Room Temperature
Authors: Dey Pritha , Dixit Tejendra , Mishra Vikash , Sahoo Anubhab , Vijayan Cheriyanath , Krishnan Sivarama 
Published: May 2023

AbstractLow‐dimensional transition metal dichalcogenide (TMDC) materials are heralding a new era in optoelectronics and valleytronics owing to their unique properties. Photo‐induced dynamics in these systems is mostly studied from the perspective of individual quasi‐particles—excitons, bi‐excitons, or, even, trions—their formation, evolution, and decay. The role of multi‐body and exciton dynamics, the associated collective behavior, condensation, and inter‐excitonic interactions remain intriguing and seek attention, especially in room‐temperature scenarios that are relevant for device applications. In this work, the formation and decay of an unexpected electron–hole quantum liquid phase at room‐temperature on ultrafast timescales in multi‐layer MoS2 nanoparticles is evidenced through femtosecond broadband transient absorption spectroscopy. The studies presented here reveal the complete dynamical picture: the initial electron–hole plasma (EHP) condenses into a quantum electron–hole liquid (EHL) phase that typically lasts as long as 10 ps, revealing its robustness, whereafter the system decays through phonons. The authors employ a successful physical model using a set of coupled nonlinear rate equations governing the individual populations of these constituent phases to extract their contributions to bandgap renormalization (BGR). Beyond the observation of the electron–hole liquid‐like state at room temperature, this work reveals the ultrafast dynamics of photo‐excited low‐dimensional systems arising out of collective many‐particle behavior and correlations.
A Highly Sensitive Triboelectric Quasi‐Zero Stiffness Vibration Sensor with Ultrawide Frequency Response
Authors: Wu Pengfan , Wang Fayang , Xu Shiwei , Liu Tao , Qi Youchao , Zhao Xue , Zhang Chi , Mu Xiaojing 
Published: May 2023

AbstractSensors based on triboelectric nanogenerators (TENGs) have gained worldwide interest owing to their advantages of low cost and self‐powering. However, the detection of most triboelectric vibration sensors (TVS) is restricted to low frequency, whereas high‐frequency vibration signals are successfully measured in recent studies; their sensitivity still requires improvement. Hence, a highly sensitive vibration sensor based on TENG (HSVS‐TENG) with ultrawide frequency response is presented. This study is the first to introduce a quasi‐zero stiffness structure into the TENG to minimize the driving force by optimizing the magnetic induction intensity and the weight of the moving part. The results show that the HSVS‐TENG can measure vibrations with frequencies ranging from 2.5 to 4000 Hz, with a sensitivity ranging from 0.32 to 134.9 V g−1. Moreover, the sensor exhibits a good linear response versus the applied acceleration, and the linearity ranges from 0.08 to 2.81 V g−1. The self‐powered sensor can monitor the running state and fault type of the key components with a recognition accuracy of 98.9% by leveraging machine‐learning algorithms. The results reach a new height for the ultrawide frequency response and high sensitivity of the TVS and provide an idea for a follow‐up high‐resolution TVS.
Enhanced Stretchability of Wavy‐Structured Thermally Grown Silicon Dioxide Films for Stretchable Encapsulation
Authors: Kim Hangeul , Hwang Gyeong‐Seok , Lee Sukbin , Kim Ju‐Young 
Published: May 2023

AbstractAligned wavy‐structured thermally grown silicon dioxide films are fabricated for stretchable encapsulation films. Uniaxial stretchability is investigated with micromechanics modeling, which can elucidate the stretchability arising from the wavy structure and the properties of the materials. The wavy‐structured films with optimum combinations of film thickness and wavy structure show 20.1% of uniaxial stretchability and 1.11 × 10−6 g m−2 day−1 of water vapor transmission rate (WVTR), simultaneously. It shows highly reliable barrier properties even after 1000 stretching cycles at 90% of their stretchability.
Response of Camellia sinensis var.assamica suitable areas to climate change—Evidence from Yunnan province (China)
Authors: Yi Qi , Gao Yuting , Dou Xiaodong , Peng Qiyang , Shen Yinghua , Ji Wenjuan , Liu Yujie 
Published: May 2023

AbstractThis study is an attempt to explore the regional resilience of Camellia sinensis var.assamica cultivation with climate change in Yunnan Province and delineate the scope of its potential suitable areas at three levels. Based on the maximum entropy (MaxEnt) model, combined with the distribution data of C. sinensis var.assamica species and environmental variable data, the main influencing factors of its distribution were figured out, and the suitable growing areas of C. sinensis var.assamica under the current and future climate conditions were predicted. The results show (1) the MaxEnt model can be deliberately constructed for the prediction of the suitable distribution areas of C. sinensis var.assamica in Yunnan. The dominant environmental factors affecting the planting of it are the average rainfall in October, the soil type and the mountain slope, having a contribution ratio of 84.9% with a total. (2) Under the current climate condition, the areas suitable for C. sinensis var.assamica are mainly in the west, southwest and south regions of Yunnan. The total suitable areas account for approximately 37.55% of Yunnan. The highly suitable areas are surrounded by moderately suitable areas which are surrounded by low suitable areas. (3) In the scenarios of RCP4.5 and RCP8.5, the total suitable area shows an increasing trend, reaching 41.76% and 52.30% of the land area of Yunnan Province, respectively. With higher carbon emissions, the increase in suitable area will be greater. The centroid of the suitable area would migrate toward higher altitude and higher latitude. The growers can adjust the suitable areas according to the local climate and terrain conditions and the conclusions of this paper to cope with impact of climate change on the yield of C. sinensis var.assamica.
Yield tradeoffs of early corn harvest to enhance pennycress establishment
Authors: Mohammed Yesuf Assen , Gesch Russ W. , Wells Samantha S. , Heller Nicholas J. , Lindsey Alexander J. , Hard Alexander W. , Phippen Winthrop B. , Bedeker Bethany 
Published: May 2023

AbstractOilseed pennycress (Thlaspi arvense L.) establishment following grain corn (Zea mays L.) harvest in northern latitudes is challenging because of the short duration between corn harvest and soil freeze. The use of shorter season corn hybrids for a region may partly solve this challenge, but tradeoffs in reduced corn yield may be a concern. This study evaluated corn relative maturity (CRM) hybrids on pennycress establishment, seed and oil yields, and corn grain yield tradeoffs. The CRM hybrids ranged from 76‐ to 95‐day for northern sites (Morris and Rosemount, MN), and from 95‐ to 113‐day for the southern sites (Custar, OH, and Lexington, IL). The checks were full‐season corn (113‐ and 95‐day corn for the southern and the northern sites, respectively) harvested for silage. Pennycress plant density, green cover, and yield were generally greater when pennycress was seeded following silage corn due to early seeding and reduced corn stover. Pennycress seed yields ranged from 388 to 778, 641 to 834, 362 to 784, and 834 to 2038 kg ha−1 at Custar, Lexington, Morris, and Rosemount, respectively. The results showed that growing 86‐ and 105‐day grain corn in the northern and southern sites, respectively, facilitated timely pennycress establishment with little or no corn grain yield loss compared with full‐season hybrids. Developing pennycress varieties better suited for emergence under high corn stover or employing stover management practices to increase autumn emergence is suggested. Additionally, an economic analysis of the entire cropping sequence (corn–pennycress–soybean) is needed.
Inpatient epidemiology, healthcare utilization, and association with comorbidities of Turner syndrome: A National Inpatient Sample study
Authors: Chenbhanich Jirat , Ungprasert Patompong , Kroner Paul T. 
Published: May 2023

AbstractWe aimed to investigate the prevalence, resource utilization, and comorbidities of patients with Turner syndrome (TS) hospitalized in the United States. We identified patients within the Nationwide Inpatient Sample database from the year 2017 to 2019. A propensity‐matched cohort of non‐TS patients from the same database was constructed to serve as comparators. There were 9845 TS patients, corresponding to inpatient prevalence of 10.4 per 100,000 admissions. The most common admission diagnosis was sepsis (27.9%). TS patients had higher inpatient mortality (adjusted odds ratio 2.16, 95% confidence interval 1.57–2.96) and morbidity, including shock, ICU admission, acute kidney injury, systemic inflammatory response syndrome, acute respiratory distress syndrome, and multi‐organ failure. Increased risk of comorbidities, such as stroke, myocardial infarction, autoimmune diseases, and non‐variceal gastrointestinal bleeding, was observed. TS patients had longer length of stay (LOS; 5.1 days vs. 4.5 days, p < 0.01) and displayed a mean additional $5382 (p < 0.01) in total hospital costs and a mean additional $20,083 (p < 0.01) in total hospitalization charges. In conclusion, hospitalization of patients with TS was associated with a significantly higher inpatient morbidity, mortality, expenditures, and longer LOS compared to non‐TS patients. Patients with TS had a higher risk of cardiovascular complications, autoimmune diseases, and gastrointestinal bleeding.
Autism and mild epilepsy associated with a de novo missense pathogenic variant in the GTPase effector domain of DNM1
Authors: Mei Davide , Parrini Elena , Bianchini Claudia , Ricci Maria Luisa , Guerrini Renzo 
Published: May 2023

AbstractDynamin 1 is a GTPase protein involved in synaptic vesicle fission, which facilitates the exocytosis of neurotransmitters necessary for normal signaling. Pathogenic variants in the DNM1 gene are associated with intractable epilepsy, often manifested as infantile spasms at onset, developmental delay, and a movement disorder, and are located in the GTPase and middle domains of the protein. We describe a 36‐year‐old man with autism and moderate intellectual disability who experienced only a few generalized seizures between the age 16 and 30 years. Using a whole sequencing approach, we identified the c.1994T>C p.(Leu665Pro) de novo novel missense pathogenic variant in the GTPase effector domain (GED) of the DNM1 protein. Structural analyses suggest that this substitution impairs both the stalk formation and its interactions, known to be important for the dynamin‐1 physiological cellular function. Our data expand the spectrum of phenotypes associated with pathogenic variants in the DNM1 gene, linking a variant in the GED domain with autism and onset in the adolescence of mild epilepsy, a phenotypic presentation remarkably different from the early infantile epileptic encephalopathy associated with pathogenic variants in the GTPase or middle domains.
Determining the association of insurance coverage and survival outcomes in patients with olfactory neuroblastoma utilizing machine learning
Authors: Fenton David , Diaz Ashley , Chen Haobin , Armstrong Mikhayla , Auger Samuel , Bujnowski Daniel , Pedroza Alena , Polster Sean , Das Paramita , Horowitz Peleg , Roxbury Christopher 
Published: May 2023

Key points
We use machine learning to examine health insurance and mortality in olfactory neuroblastoma.
Private insurance significantly improved survival even after adjusting for confounders.
The regression model also found no statistical difference between Medicare and no insurance.
Whole‐genome sequencing study to identify candidate markers indicating susceptibility to type 2 diabetes in Bama miniature pigs
Authors: Niu Miaomiao , Zhao Yuqiong , Jia Yunxiao , Xiang Lei , Dai Xin , Chen Hua 
Published: May 2023

AbstractBackgroundHundreds of single‐nucleotide polymorphism (SNP) sites have been found to be potential genetic markers of type 2 diabetes mellitus (T2DM). However, SNPs related to T2DM in minipigs have been less reported. This study aimed to screen the T2DM‐susceptible candidate SNP loci in Bama minipigs so as to improve the success rate of the minipig T2DM model.MethodsThe genomic DNAs of three Bama minipigs with T2DM, six sibling low‐susceptibility minipigs with T2DM, and three normal control minipigs were compared by whole‐genome sequencing. The T2DM Bama minipig‐specific loci were obtained, and their functions were annotated. Meanwhile, the Biomart software was used to perform homology alignment with T2DM‐related loci obtained from the human genome‐wide association study to screen candidate SNP markers for T2DM in Bama miniature pigs.ResultsWhole‐genome resequencing detected 6960 specific loci in the minipigs with T2DM, and 13 loci corresponding to 9 diabetes‐related genes were selected. Further, a set of 122 specific loci in 69 orthologous genes of human T2DM candidate genes were obtained in the pigs. Collectively, a batch of T2DM‐susceptible candidate SNP markers in Bama minipigs, covering 16 genes and 135 loci, was established.ConclusionsWhole‐genome sequencing and comparative genomics analysis of the orthologous genes in pigs that corresponded to the human T2DM‐related variant loci successfully screened out T2DM‐susceptible candidate markers in Bama miniature pigs. Using these loci to predict the susceptibility of the pigs before constructing an animal model of T2DM may help to establish an ideal animal model.
Simultaneous Generation of H2O2 and Formate by Co‐Electrolysis of Water and CO2 over Bifunctional Zn/SnO2 Nanodots
Authors: Hu Xin , Mei Guoliang , Chen Xiangxiong , Liu Jinlong , Xia Bao Yu , You Bo 
Published: May 2023

AbstractHydrogen peroxide (H2O2) and formate are important chemicals used in various chemical manufacturing industries. One promising approach for the simultaneous production of these chemicals is coupling anodic two‐electron water oxidation with cathodic CO2 reduction in an electrolyzer using nonprecious bifunctional electrocatalysts. Herein, we report an innovative hybrid electrosynthesis strategy using Zn‐doped SnO2 (Zn/SnO2) nanodots as bifunctional redox electrocatalysts to achieve Faradaic efficiencies of 80.6 % and 92.2 % for H2O2 and formate coproduction, respectively, along with excellent stability for at least 60 h at a current density of ≈150 mA cm−2. Through a combination of physicochemical characterizations, including operando attenuated total reflectance‐Fourier transform infrared spectroscopy (ATR‐FTIR), isotope labeling mass spectrometry (MS)/1H NMR and quasi‐in situ electron paramagnetic resonance (EPR), with density functional theory (DFT) calculations, we discovered that the Zn dopant facilitates the coupling of *OH intermediates to promote H2O2 production and optimizes the adsorption of *OCHO intermediates to accelerate formate formation. Our findings offer new insights into designing more efficient bifunctional electrocatalyst‐based pair‐electrosynthesis system for the coproduction of H2O2 and formate feedstocks.
Interfacial Ti−S Bond Modulated S‐Scheme MOF/Covalent Triazine Framework Nanosheet Heterojunctions for Photocatalytic C−H Functionalization
Authors: Gao Zhu , Jian Yi , Yang Song , Xie Qiujian , Ross Mcfadzean Charles Joseph , Wei Baosheng , Tang Juntao , Yuan Jiayin , Pan Chunyue , Yu Guipeng 
Published: May 2023

AbstractConstructing photocatalyst systems to functionalize the inert C−H bonds has attracted extensive research interest. However, purposeful modulation of interfacial charge transfer in heterostructures remains a challenge, as it usually suffers from sluggish kinetics. Reported herein is an easy strategy to construct the heteroatom‐induced interface for developing the titanium‐organic frameworks (MOF‐902) @ thiophene‐based covalent triazine frameworks (CTF‐Th) nanosheets S‐scheme heterojunctions with controllable oxygen vacancies (OVs). Specifically, Ti atoms were first anchored onto the heteroatom site of CTF‐Th nanosheets, and then grown into MOF‐902 via an interfacial Ti−S linkage, generating OVs. Using in situ X‐ray photoelectron spectroscopy (XPS), extended X‐ray absorption fine structure (EXAFS) spectroscopy and density functional theory (DFT) calculations, the enhanced interfacial charge separation and transfer induced by moderate OVs in the pre‐designed S‐scheme nanosheets was validated. The heterostructures exhibited an improved efficiency in photocatalytic C3‐acylation of indoles under mild conditions with a yield 8.2 times larger than pristine CTF‐Th or MOF‐902 and enabled an extended scope of substrates (15 examples). This performance is superior to state‐of‐the‐art photocatalyst and can be retained, without significant loss, after 12 consecutive cycles.