bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nonlinear amplification of microwave signals in spin-torque oscillators
Authors: Zhu Keqiang , Carpentieri Mario , Zhang Like , Fang Bin , Cai Jialin , Verba Roman , Giordano Anna , Puliafito Vito , Zhang Baoshun , Finocchio Giovanni , Zeng Zhongming 
Published: April 2023

AbstractSpintronics-based microwave devices, such as oscillators and detectors, have been the subject of intensive investigation in recent years owing to the potential reductions in size and power consumption. However, only a few concepts for spintronic amplifiers have been proposed, typically requiring complex device configurations or material stacks. Here, we demonstrate a spintronic amplifier based on two-terminal magnetic tunnel junctions (MTJs) produced with CMOS-compatible material stacks that have already been used for spin-transfer torque memories. We achieve a record gain (|S11 | > 2) for input power on the order of nW (<−40 dBm) at an appropriate choice of the bias field direction and amplitude. Based on micromagnetic simulations and experiments, we describe the fundamental aspects driving the amplification and show the key role of the co-existence in microwave emissions of a dynamic state of the MTJ excited by a dc current and the injection locking mode driven by the microwave input signal. Our work provides a way to develop a class of compact amplifiers that can impact the design of the next generation of spintronics-CMOS hybrid systems.
Manipulating exchange bias in 2D magnetic heterojunction for high-performance robust memory applications
Authors: Huang Xinyu , Zhang Luman , Tong Lei , Li Zheng , Peng Zhuiri , Lin Runfeng , Shi Wenhao , Xue Kan-Hao , Dai Hongwei , Cheng Hui , de Camargo Branco Danilo , Xu Jianbin , Han Junbo , Cheng Gary J. , Miao Xiangshui , Ye Lei 
Published: April 2023

AbstractThe exchange bias (EB) effect plays an undisputed role in the development of highly sensitive, robust, and high-density spintronic devices in magnetic data storage. However, the weak EB field, low blocking temperature, as well as the lack of modulation methods, seriously limit the application of EB in van der Waals (vdW) spintronic devices. Here, we utilized pressure engineering to tune the vdW spacing of the two-dimensional (2D) FePSe3/Fe3GeTe2 heterostructures. The EB field (HEB, from 29.2 mT to 111.2 mT) and blocking temperature (Tb, from 20 K to 110 K) are significantly enhanced, and a highly sensitive and robust spin valve is demonstrated. Interestingly, this enhancement of the EB effect was extended to exposed Fe3GeTe2, due to the single-domain nature of Fe3GeTe2. Our findings provide opportunities for the producing, exploring, and tuning of magnetic vdW heterostructures with strong interlayer coupling, thereby enabling customized 2D spintronic devices in the future.
Stomatal responses of terrestrial plants to global change
Authors: Liang Xingyun , Wang Defu , Ye Qing , Zhang Jinmeng , Liu Mengyun , Liu Hui , Yu Kailiang , Wang Yujie , Hou Enqing , Zhong Buqing , Xu Long , Lv Tong , Peng Shouzhang , Lu Haibo , Sicard Pierre , Anav Alessandro , Ellsworth David S. 
Published: April 2023

AbstractQuantifying the stomatal responses of plants to global change factors is crucial for modeling terrestrial carbon and water cycles. Here we synthesize worldwide experimental data to show that stomatal conductance (gs) decreases with elevated carbon dioxide (CO2), warming, decreased precipitation, and tropospheric ozone pollution, but increases with increased precipitation and nitrogen (N) deposition. These responses vary with treatment magnitude, plant attributes (ambient gs, vegetation biomes, and plant functional types), and climate. All two-factor combinations (except warming + N deposition) significantly reduce gs, and their individual effects are commonly additive but tend to be antagonistic as the effect sizes increased. We further show that rising CO2 and warming would dominate the future change of plant gs across biomes. The results of our meta-analysis provide a foundation for understanding and predicting plant gs across biomes and guiding manipulative experiment designs in a real world where global change factors do not occur in isolation.
Distinct astrocytic modulatory roles in sensory transmission during sleep, wakefulness, and arousal states in freely moving mice
Authors: Wang Fushun , Wang Wei , Gu Simeng , Qi Dan , Smith Nathan A. , Peng Weiguo , Dong Wei , Yuan Jiajin , Zhao Binbin , Mao Ying , Cao Peng , Lu Qing Richard , Shapiro Lee A. , Yi S. Stephen , Wu Erxi , Huang Jason H. 
Published: April 2023

AbstractDespite extensive research on astrocytic Ca2+ in synaptic transmission, its contribution to the modulation of sensory transmission during different brain states remains largely unknown. Here, by using two-photon microscopy and whole-cell recordings, we show two distinct astrocytic Ca2+ signals in the murine barrel cortex: a small, long-lasting Ca2+ increase during sleep and a large, widespread but short-lasting Ca2+ spike when aroused. The large Ca2+ wave in aroused mice was inositol trisphosphate (IP3)-dependent, evoked by the locus coeruleus-norepinephrine system, and enhanced sensory input, contributing to reliable sensory transmission. However, the small Ca2+ transient was IP3-independent and contributed to decreased extracellular K+, hyperpolarization of the neurons, and suppression of sensory transmission. These events respond to different pharmacological inputs and contribute to distinct sleep and arousal functions by modulating the efficacy of sensory transmission. Together, our data demonstrate an important function for astrocytes in sleep and arousal states via astrocytic Ca2+ waves.
Altered human gut virome in patients undergoing antibiotics therapy for Helicobacter pylori
Authors: Wang Lingling , Yao Haobin , Morgan Daniel C. , Lau Kam Shing , Leung Suet Yi , Ho Joshua W. K. , Leung Wai K. 
Published: April 2023

AbstractTransient gut microbiota alterations have been reported after antibiotic therapy for Helicobacter pylori. However, alteration in the gut virome after H. pylori eradication remains uncertain. Here, we apply metagenomic sequencing to fecal samples of 44 H. pylori-infected patients at baseline, 6-week (N = 44), and 6-month (N = 33) after treatment. Following H. pylori eradication, we discover contraction of the gut virome diversity, separation of virome community with increased community difference, and shifting towards a higher proportion of core virus. While the gut microbiota is altered at 6-week and restored at 6-month, the virome community shows contraction till 6-month after the treatment with enhanced phage-bacteria interactions at 6-week. Multiple courses of antibiotic treatments further lead to lower virus community diversity when compared with treatment naive patients. Our results demonstrate that H. pylori eradication therapies not only result in transient alteration in gut microbiota but also significantly alter the previously less known gut virome community.
All-natural phyllosilicate-polysaccharide triboelectric sensor for machine learning-assisted human motion prediction
Authors: Liu Yuanhao , Shen Yiwen , Ding Wei , Zhang Xiangkun , Tian Weiliang , Yang Song , Hui Bin , Zhang Kewei 
Published: April 2023

AbstractThe rapid development of smart and carbon-neutral cities motivates the potential of natural materials for triboelectric electronics. However, the relatively deficient charge density makes it challenging to achieve high Maxwell’s displacement current. Here, we propose a methodology for improving the triboelectricity of marine polysaccharide by incorporating charged phyllosilicate nanosheets. As a proof-of-concept, a flexible, flame-retardant, and eco-friendly triboelectric sensor is developed based on all-natural composite paper from alginate fibers and vermiculite nanosheets. The interlaced fibers and nanosheets not only enable superior electrical output but also give rise to wear resistance and mechanical stability. The fabricated triboelectric sensor successfully monitors slight motion signals from various joints of human body. Moreover, an effective machine-learning model is developed for human motion identification and prediction with accuracy of 96.2% and 99.8%, respectively. This work offers a promising strategy for improving the triboelectricity of organo-substrates and enables implementation of self-powered and intelligent platform for emerging applications.
Motixafortide and G-CSF to mobilize hematopoietic stem cells for autologous transplantation in multiple myeloma: a randomized phase 3 trial
Authors: Crees Zachary D. , Rettig Michael P. , Jayasinghe Reyka G. , Stockerl-Goldstein Keith , Larson Sarah M. , Arpad Illes , Milone Giulio A. , Martino Massimo , Stiff Patrick , Sborov Douglas , Pereira Denise , Micallef Ivana , Moreno-Jiménez Gemma , Mikala Gabor , Coronel Maria Liz Paciello , Holtick Udo , Hiemenz John , Qazilbash Muzaffar H. , Hardy Nancy , Latif Tahir , García-Cadenas Irene , Vainstein-Haras Abi , Sorani Ella , Gliko-Kabir Irit , Goldstein Inbal , Ickowicz Debby , Shemesh-Darvish Liron , Kadosh Shaul , Gao Feng , Schroeder Mark A. , Vij Ravi , DiPersio John F. 
Published: April 2023

AbstractAutologous hematopoietic stem cell transplantation (ASCT) improves survival in multiple myeloma (MM). However, many individuals are unable to collect optimal CD34+ hematopoietic stem and progenitor cell (HSPC) numbers with granulocyte colony-stimulating factor (G-CSF) mobilization. Motixafortide is a novel cyclic-peptide CXCR4 inhibitor with extended in vivo activity. The GENESIS trial was a prospective, phase 3, double-blind, placebo-controlled, multicenter study with the objective of assessing the superiority of motixafortide + G-CSF over placebo + G-CSF to mobilize HSPCs for ASCT in MM. The primary endpoint was the proportion of patients collecting ≥6 × 106 CD34+ cells kg–1 within two apheresis procedures; the secondary endpoint was to achieve this goal in one apheresis. A total of 122 adult patients with MM undergoing ASCT were enrolled at 18 sites across five countries and randomized (2:1) to motixafortide + G-CSF or placebo + G-CSF for HSPC mobilization. Motixafortide + G-CSF enabled 92.5% to successfully meet the primary endpoint versus 26.2% with placebo + G-CSF (odds ratio (OR) 53.3, 95% confidence interval (CI) 14.12–201.33, P < 0.0001). Motixafortide + G-CSF also enabled 88.8% to meet the secondary endpoint versus 9.5% with placebo + G-CSF (OR 118.0, 95% CI 25.36–549.35, P < 0.0001). Motixafortide + G-CSF was safe and well tolerated, with the most common treatment-emergent adverse events observed being transient, grade 1/2 injection site reactions (pain, 50%; erythema, 27.5%; pruritis, 21.3%). In conclusion, motixafortide + G-CSF mobilized significantly greater CD34+ HSPC numbers within two apheresis procedures versus placebo + G-CSF while preferentially mobilizing increased numbers of immunophenotypically and transcriptionally primitive HSPCs. Trial Registration: ClinicalTrials.gov, NCT03246529
Improvement of muscle strength in specific muscular regions in nusinersen-treated adult patients with 5q-spinal muscular atrophy
Authors: Schreiber-Katz Olivia , Siegler Hannah Alexandra , Wieselmann Gary , Kumpe Mareike , Ranxha Gresa , Petri Susanne , Osmanovic Alma 
Published: April 2023

AbstractReal-world data have shown mild improvement of overall motor function in adult patients treated with nusinersen, the first approved therapy for 5q-spinal muscular atrophy (SMA). However, knowledge about preferably targeted muscle functions is sparse. The aim of this study was to evaluate strength of distinct muscles and body regions in adult SMA patients in the early course of nusinersen therapy. 72 muscles of 15 patients were tested on the Medical Research Council (MRC) 0–10 scale (translated into MRC %) from nusinersen start to 14 months of treatment. The whole body muscular strength improved slightly or remained stable in 80% of SMA patients with a median improvement of + 2%. However, relevant increases of muscle strength of distinct regions were identified in the proximal upper limbs and shoulder girdle (median + 8%) and in muscle groups with a preserved function pre-treatment, even in more advanced diseased SMA patients. MRC grading was additionally performed in seven patients enrolled during ongoing treatment. Here, further improvement of muscle strength until month 18–26 was seen with the highest increases in the proximal upper and lower limbs. Our findings suggest that sole evaluation of the overall muscle strength might underestimate nusinersen therapy benefits.
Non-enzymatic glucose sensors composed of trimetallic CuO/Ag/NiO based composite materials
Authors: Naikoo Gowhar A. , Bano Mustri , Arshad Fareeha , Hassan Israr U. , BaOmar Fatima , Alfagih Iman M. , Tambuwala Murtaza M. 
Published: April 2023

AbstractThe escalating risk of diabetes and its consequential impact on cardiac, vascular, ocular, renal, and neural systems globally have compelled researchers to devise cost-effective, ultrasensitive, and reliable electrochemical glucose sensors for the early diagnosis of diabetes. Herein, we utilized advanced composite materials based on nanoporous CuO, CuO/Ag, and CuO/Ag/NiO for glucose detection. The crystalline structure and surface morphology of the synthesized materials were ascertained via powder X-ray diffraction (P-XRD), energy dispersive X-ray (EDX) spectroscopy, scanning electron microscopy (SEM) and transmission electron microscopy (TEM) analysis. The electro-catalytic properties of the manufactured electrode materials for glucose electro-oxidation in alkaline conditions were probed using cyclic voltammetry (CV) and differential pulse voltammetry (DPV) techniques. Notably, the CuO/Ag/NiO electrode material exhibited exceptional performance as a non-enzymatic glucose sensor, displaying a linear range of 0.001–5.50 mM, an ultrahigh sensitivity of 2895.3 μA mM−1 cm−2, and a low detection limit of 0.1 μM. These results suggest that nanoporous CuO/Ag/NiO-based composite materials are a promising candidate for early diagnosis of hyperglycemia and treatment of diabetes. Furthermore, non-enzymatic glucose sensors may pave the way for novel glucometer markets.
Factors influencing bamboo intake of captive giant pandas (Ailuropoda melanoleuca)
Authors: Wei Ming , Zhu Yan , Liu Weiping , Li Desheng , Wei Rongping , Deng Linhua , Wu Kai , Song Shixian , Li Ti , Zeng Wen , He Yongguo , Huang Shan , Wang Chengdong 
Published: April 2023

AbstractBamboo is the main food source of the giant panda. To increase bamboo intake in captive giant pandas, we studied factors affecting the bamboo intake. Fourteen healthy captive giant pandas in Dujiangyan Base of China Conservation and Research Center for The Giant Panda (“Dujiangyan Base” for short) were selected as research objects. A bamboo feeding experiment was conducted to study the effects of seasons, bamboo age, slope orientations where bamboo grows and felling-feeding time on bamboo intake of the giant panda. We found that the type of bamboo that captive giant pandas feed on was abundant in spring and summer, but relatively homogeneous in winter. With the increase of bamboo age, the intake of bamboo leaves decreased, while bamboo culms increased. The feed intake of 1-year-old bamboo leaves and 5-year-old bamboo culms reached the highest respectively. The slope orientation also affected the panda's bamboo intake, and the bamboo growing on sunny slopes or semi-sunny slopes was more favored by captive giant pandas. Moreover, the bamboo intake reached the highest when felling-feeding time was less than 24 h. In short, we confirmed that seasons, bamboo age, slope orientations and felling-feeding time were factors affecting bamboo intake for captive giant pandas. This study was expected to provide scientific guidance improving the feeding behavior management of captive giant pandas.
The prognostic value of hedgehog signaling in bladder cancer by integrated bioinformatics
Authors: Yu Xin , Li Wenge , Feng Yanjun , Gao Zhijie , Wu Qi , Xia Yue 
Published: April 2023

AbstractBladder cancer is the second most prevalent urological malignancy. It's a big contributor to cancer-related deaths throughout the globe. Researchers discovered that the hedgehog signaling (HhS) pathway contributed to the onset and spread of many different kinds of cancer. Nevertheless, the present understanding of the function of HhS in the bladder cancer molecular landscape is incomplete. Raw data were gotten from the IMvigor210, the Gene Expression Omnibus, and The Cancer Genome Atlas databases. Bioinformatics was used to examine the HhS score of each sample, and the enrichment of differentially expressed genes (DEGs), differentiation characteristics, immunological infiltration, and metabolic activity. The HhS prognostic signature was developed with significant assistance from the least absolute shrinkage and selection operator regression and Cox regression. An HhS-related nomogram was developed to assist in the prediction of patients’ survival probability. We found that HhS was linked to poor prognosis in bladder cancer, and its activation was linked to the Basal subtype of bladder cancer. Bladder cancer with high HhS activity has higher glycolysis, nucleotide metabolism, amino acid metabolism, and other cancer-promoting metabolic activities. Furthermore, HhS mediates an immunosuppressive microenvironment in bladder cancer on the basis that HhS negatively correlates with the CD8 + T cells and correlates positively with immune checkpoints and T cell exhaustion scores. Finally, an HhS-related signature was developed for predicting the prognosis of patients with bladder cancer. Targeting HhS may be a potential therapy choice for bladder cancer.
Turbulent flow interacting with flexible trawl net structure including simulation catch in flume tank
Authors: Nyatchouba Nsangue Bruno Thierry , Tang Hao , Liu Wei , Xu Liuxiong , Hu Fuxiang 
Published: April 2023

AbstractThe interaction between fluid and the midwater trawl with stocked catches is extremely complex, but essential to improve the understanding of the drag force acting on the trawl, the behavior of the fishing structure during a trawling process, and to predict its selectivity process. The present study assesses the turbulent characteristics inside and around the midwater trawls with catch and without catch linked to its fluttering motion. The analysis is based on three-dimensional electromagnetic current velocity meter measurements performed in the multiple points inside and outside different parts of a 1/35 scaled midwater trawl model with the aim of access the main turbulent flow structure inside and around the gear. Time-averaged normalized flow velocity fields and turbulent flow parameters were analyzed from the measured flow data. Furthermore, Fourier analysis was conducted by watching the time–frequency Power spectrum content of instantaneous flow velocities fields, the fluttering trawl motions, turbulent kinetic energy, and momentum flux. Based on successive analyzes of mean flow characteristics and turbulent flow parameters, it has been demonstrated that the presence of catch inside the trawl net impacts the evolution of unsteady turbulent flow by creating large trawl fluttering motions that strongly affect the flow passage. The results showed that the time-averaged normalized streamwise and transverse flow velocities inside and around the trawl net with catch were 12.41% lower compared with that obtained inside and around the trawl without catch. The turbulent length scale and turbulent Reynolds number obtained in the different part of the trawl net with catch were about 33.05% greater than those obtained on the trawl net without catch, confirming that the unsteady turbulent flow developing inside and around the midwater trawl is influence by the catch and liner. It is observed that the motions of both the trawl without catch and the trawl with catch are mainly of a low-frequency activity and another component related to unsteady turbulent flow street. A complex fluid–structure interaction is then demonstrated where the fluttering motions of the trawl net affect the fluid flow inside and around trawl net, the fluid force, turbulent pattern, and simultaneously, the periodic unsteady turbulent flow influence the trawl motions.
A head-to-head comparison of well-being of older people (WOOP) and EQ-5D-5L in patients, carers and general public in China
Authors: Ran Xun , Mao Zhuxin , Yang Zhihao 
Published: April 2023

AbstractRecently, well-being of older people measure (WOOP) was developed and validated in a Dutch population. Although WOOP was developed targeting the older people, it has the potential for use in a wider population. In this study, we aimed to examine the relationship between WOOP and EQ-5D-5L and compared their psychometric properties in a sample of patients, carers and healthy general public covering a wider age group. We conducted a cross-sectional study in Guizhou Province, China between July and August 2022. Data was collected using paper and pencil. We analysed and reported the acceptability, item response distribution, the Spearman correlation coefficients of all items, the Exploratory Factor Analysis (EFA) of all items, the known-group validity and the convergent validity of EQ-5D-5L utility and WOOP utility. A total of 322 participants completed the survey with 105 patients, 101 carers and 116 healthy general public. 9% of participants had at least one missing response. Three items of WOOP did not have any level 5 responses and EQ-5D-5L had more level 1 responses. The correlations were low between EQ-5D-5L and WOOP items and the three-factor EFA showed these two instruments had only one shared factor and the other two factors were only related to WOOP items. Younger people had lower missing response rate and a different response distribution for three items. WOOP measures a broader construct beyond health while EQ-5D-5L is a more sensitive instrument when health is considered alone. There is a potential of using WOOP in a wider population.
Pyrolytic elimination of ethylene from ethoxyquinolines and ethoxyisoquinolines: a computational study
Authors: Abdel-Rahman Mohamed A. , Shibl Mohamed F. , Mahmoud Mohamed A. M. 
Published: April 2023

AbstractThis work reports a thermo-kinetic study on unimolecular thermal decomposition of some ethoxyquinolines and ethoxyisoquinolines derivatives (1-ethoxyisoquinoline (1-EisoQ), 2-ethoxyquinoline (2-EQ), 3-ethoxyquinoline (3-EQ), 3-ethoxyisoquinoline (3-EisoQ), 4-ethoxyquinoline (4-EQ), 4-ethoxyisoquinoline (4-EisoQ), 5-ethoxyquinoline (5-EQ), 5-ethoxyisoquinoline (5-EisoQ), 8-ethoxyquinoline (8-EQ) and 8-ethoxyisoquinoline (8-EisoQ)) using density functional theory DFT (BMK, MPW1B95, M06-2X) and ab initio complete basis set-quadratic Becke3 (CBS-QB3) calculations. In the course of the decomposition of the investigated systems, ethylene is eliminated with the production of either keto or enol tautomer. The six-membered transition state structure encountered in the path of keto formation is much lower in energy than the four-membered transition state required to give enol form. Rate constants and activation energies for the decomposition of 1-EisoQ, 2-EQ, 3-EQ, 3-EisoQ, 4-EQ, 4-EisoQ, 5-EQ, 5-EisoQ, 8-EQ, and 8-EisoQ have been estimated at different temperatures and pressures using conventional transition state theory combined with Eckart tunneling and the unimolecular statistical Rice–Ramsperger–Kassel–Marcus theories. The tunneling correction is significant at temperatures up to 1000 K. Rate constants results reveal that ethylene elimination and keto production are favored kinetically and thermodynamically over the whole temperature range of 400–1200 K and the rates of the processes under study increase with the rising of pressure up to 1 atm.