bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Scoping Review of Artificial Intelligence Research in Rhinology
Authors: Osie Gabriel , Darbari Kaul Rhea , Alvarado Raquel , Katsoulotos Gregory , Rimmer Janet , Kalish Larry , Campbell Raewyn G. , Sacks Raymond , Harvey Richard J. 
Published: March 2023

Background A considerable volume of possible applications of artificial intelligence (AI) in the field of rhinology exists, and research in the area is rapidly evolving. Objective This scoping review aims to provide a brief overview of all current literature on AI in the field of rhinology. Further, it aims to highlight gaps in the literature for future rhinology researchers. Methods OVID MEDLINE (1946-2022) and EMBASE (1974-2022) were searched from January 1, 2017 until May 14, 2022 to identify all relevant articles. The Preferred Reporting Items for Systematic Reviews and Meta-analyses Extension for Scoping Reviews checklist was used to guide the review. Results A total of 2420 results were identified of which 62 met the eligibility criteria. A further 17 articles were included through bibliography searching, for a total of 79 articles on AI in rhinology. Each year resulted in an increase in the number of publications, from 3 articles published in 2017 to 31 articles published in 2021. Articles were produced by authors from 22 countries with a relative majority coming from the USA (19%), China (19%), and South Korea (13%). Articles were placed into 1 of 5 categories: phenotyping/endotyping (n = 12), radiological diagnostics (n = 42), prognostication (n = 10), non-radiological diagnostics (n = 7), surgical assessment/planning (n = 8). Diagnostic or prognostic utility of the AI algorithms were rated as excellent (n = 29), very good (n = 25), good (n = 7), sufficient (n = 1), bad (n = 2), or was not reported/not applicable (n = 15). Conclusions AI is experiencing an increasingly significant role in rhinology research. Articles are showing high rates of diagnostic accuracy and are being published at an almost exponential rate around the world. Utilizing AI in radiological diagnosis was the most published topic of research, however, AI in rhinology is still in its infancy and there are several topics yet to be thoroughly explored.
Placebo hypoalgesic and nocebo hyperalgesic effects in post-extraction patients—A cross sectional study
Authors: Sampath Kumar Suchithra , Bano Sidra , P Jagan 
Published: March 2023

Background and objectivesPain is an unpleasant sensory and emotional experience that affects people’s physical, mental, and social health. Patients at times present with postoperative pain with no clinical signs after the surgical dental procedures and adequate pharmacological management. This can be due to the amplified emotional component of the individual in their postoperative period. Hence, this study aimed to estimate the association between placebo, nocebo effects, and postoperative pain associated with tooth extraction procedures.MethodsA cross-sectional study was conducted among 301 patients attending the Department of Oral and Maxillofacial Surgery for tooth extraction. Preoperatively, the expected postoperative pain score was recorded using the “Numerical Rating Scale” (NRS), Anxiety and Depression were assessed using the “Hospital Anxiety and Depression Scale” (HADS), and Patients’ expectancy regarding the treatment outcome was assessed using the “Credibility Expectancy Questionnaire” (CEQ). Observed postoperative pain scores at the 6th hour, 24th hour, and peak pain score of the day were recorded using the NRS.ResultsThere were statistically significant associations ( p < 0.05) found between expected and observed postoperative pain, preoperative anxiety and observed postoperative pain, preoperative depression and observed postoperative pain, placebo, nocebo effects, and observed postoperative pain.Interpretation and conclusionOur study showed a strong association between these variables suggesting that post-extraction pain is a multifaceted condition wherein pain expectation, preoperative anxiety, depression, and expectancy regarding the treatment outcome should be scrutinized before the extraction procedure.
ADHDCoach—a virtual clinic for parents of children with ADHD: Development and usability study
Authors: Păsărelu Costina-Ruxandra , David Daniel , Dobrean Anca , Noje Alexandru , Roxana Șipoș , Predescu Elena 
Published: March 2023

Attention-deficit/ hyperactivity disorder (ADHD) is one of the most common mental health problems in childhood. Despite the fact that evidence-based treatments exist, behavioral parent training programs are the gold standard in the care of children with ADHD, a significant percentage of parents of children with ADHD do not access such interventions. Internet-delivered interventions are effective for a range of mental health problems, however, there is limited research conducted on the efficacy of such interventions in the treatment of ADHD. Objective: The aim of this study is to present the development and feasibility of an Internet-delivered intervention for parents of children with ADHD. Methods: The intervention was based on Behavioral Parent Training and Rational Emotive Behavior Therapy. Participants were mental health specialists ( N = 16) and parents of children diagnosed with ADHD ( N = 24). Results: Our results indicated high usability and parental satisfaction with the intervention. Conclusion: In conclusion, an Internet-delivered intervention addressed to parents of children diagnosed with ADHD is a promising approach. Future research should investigate the efficacy of this Internet-delivered intervention in a randomized controlled trial.
A significant burden: A qualitative exploration of the experience of women living with fibroids in St. Kitts and Nevis
Authors: Begho Abi , Waterman Fanta 
Published: March 2023

Background: Our study aimed to understand the illness experience of women living in St Kitts and Nevis who have been affected by fibroids by utilising Leventhal’s commonsense model of illness. Methods: Upon receiving ethics approval, females aged between 18 and 55 who were currently a resident in St Kitts and Nevis and who had an experience with fibroids within the last 5 years were recruited to consent and complete 1-hour interviews during which they described the different ways in which fibroids affects them. Results: The interview guide incorporated the common-sense model; all interviews were 1:1 and a thematic analysis was conducted. The final sample consisted of 11 women, 10 from St Kitts and 1 from Nevis. Their ages ranged from 23 to 49, and the average age of participants was 39 years. Participants described their fibroids in generally negative terms and noted several physical, emotional, social and professional consequences as a result of their fibroid symptoms. Conclusions: Our study revealed the need for a clear strategy for managing patients with symptomatic fibroids—a strategy that includes regular monitoring of patients, good communication between doctor and patient and clear guidance on management for patients.
Evaluating the impact of water protection policy on urban growth: A case study of Jiaxing
Authors: Guan ChengHe , Gómez Jairo A , Tripathy Pratyush , Duque Juan C , Passos Santiago , Cheng Tong , Li Ying , Keith Michael 
Published: March 2023

Source water protection can be a greater challenge in cities where the hydric resource is deeply embedded within a rapidly growing urban area. In these types of cities, the delimitation of protection areas along water resources, as one of the main mechanisms for water resource protection, has a direct impact on the way the urban form evolves. On the one hand, narrow protection areas may not be enough to guarantee that the built city does not affect water levels and quality. On the other hand, wide protection areas can result in a fragmented city, with low levels of accessibility and tendencies towards dispersed and disorderly growth. In this article we use the city of Jiaxing, China, as a case study to determine what the optimal size of water protection areas might be. For this, we use two urban growth models and simulate various urban growth scenarios between 2020 and 2040. The results indicate that a protection area of 400 m guarantees a good level of protection of the water resource and a sufficient availability of land that allows an efficient urban growth.
The Differential Impact of COVID-19 Pandemic on Sexual Behavior of Eligible Couples in Urban and Rural India
Authors: Gupta Shibaji , Bhattacharya Saikat , Banerjee Rudradeep , Chakraborty Arup , Das Debasis , De Abhishek 
Published: March 2023

Background: Intimacy during sexual contact with a person with symptomatic or asymptomatic COVID-19 disease carries the risk of its transmission. COVID-19 has been therefore found to adversely impact the sexual behavior in people in various countries. A discussion on sexual health is often tabooed in India, leading to less research evidence from India. Aim: We tried to study and compare the impact of COVID-19 pandemic on the sexual behavior of urban- and rural-based eligible couples. Methods: Eligible couples were randomly selected from the urban and rural field practice area of a Medical College of West Bengal (India). They were interviewed using a data collection schedule for their sexual practices adopted during the pandemic. Urban vs rural sexual behavior was compared using chi-square test. Results: Majority didn’t report any change in sexual desire compared to prepandemic days. However, scope of sexual contact had significantly reduced among urbanites ( P = .036); fear of contracting COVID-19 during sexual intimacy was more among them as well ( P = .047). The rural respondents reported significantly higher desire for parenthood ( P = .018), though their contraceptive behavior was not significantly different from the urban counterparts. Many used means other than sexual intercourse for sexual gratification, which had remained similar to the prepandemic times. Conclusion: The sexual behavior of urban and rural participants was found to be significantly different on many fronts, probably due to better COVID-19 awareness among urban residents as well as other prevalent social stigma and restrictions that were less commonly encountered in rural participants.
Opposing effects of KDM6A and JDP2 on glucocorticoid sensitivity in T-ALL
Authors: Levinson Anya L. , Tjoa Karensa , Huang Benjamin , Meyer Lauren K. , Kim Mi-Ok , Brady Samuel W. , Zhang Jinghui , Shannon Kevin , Wandler Anica M. 
Published: March 2023

Abstract
Glucocorticoids (GCs) are the cornerstone of acute lymphoblastic leukemia (ALL) therapy. Although mutations in NR3C1, which encodes the GC receptor (GR), and other genes involved in GC signaling occur at relapse, additional mechanisms of adaptive GC resistance are uncertain. We transplanted and treated 10 primary mouse T-lineage acute lymphoblastic leukemias (T-ALLs) initiated by retroviral insertional mutagenesis with GC dexamethasone (DEX). Multiple distinct relapsed clones from 1 such leukemia (T-ALL 8633) exhibited discrete retroviral integrations that upregulated Jdp2 expression. This leukemia harbored a Kdm6a mutation. In the human T-ALL cell line CCRF-CEM, enforced JDP2 overexpression conferred GC resistance, whereas KDM6A inactivation unexpectedly enhanced GC sensitivity. In the context of KDM6A knockout, JDP2 overexpression induced profound GC resistance, counteracting the sensitization conferred by KDM6A loss. These resistant “double mutant” cells with combined KDM6A loss and JDP2 overexpression exhibited decreased NR3C1 mRNA and GR protein upregulation upon DEX exposure. Analysis of paired samples from 2 patients with KDM6A-mutant T-ALL in a relapsed pediatric ALL cohort revealed a somatic NR3C1 mutation at relapse in 1 patient and a markedly elevated JDP2 expression in the other. Together, these data implicate JDP2 overexpression as a mechanism of adaptive GC resistance in T-ALL, which functionally interacts with KDM6A inactivation.
Natural history and rate of progression of retinopathy in adult patients with sickle cell disease: an 11-year follow-up study
Authors: Brandsen Rajani P. , Diederen Roselie M. H. , Bakhlakh Siham , Nur Erfan , Schlingemann Reinier O. , Biemond Bart J. 
Published: March 2023

AbstractSickle cell retinopathy (SCR) is a complication of sickle cell disease (SCD). Proliferative SCR (PSCR) can lead to severe visual impairment due to vitreous hemorrhage or retinal detachment. Knowledge of risk factors for progression and complications of SCR is limited. The aim of this study is to describe the natural history of SCR and to identify risk factors for progressive SCR and development of PSCR. We retrospectively analyzed disease progression in 129 patients with SCD with a median follow-up period of 11 years (interquartile range, 8.5-12). Patients were divided in 2 groups. The genotypes hemoglobin SS (HbSS), HbSβ0-thalassemia, and HbSβ+-thalassemia were grouped together (n = 83; 64.3%), whereas patients with HbSC (n = 46; 35.7%) were grouped separately. Progression of SCR was observed in 28.7% (37 of 129) of patients. Older age (adjusted odds ratio [aOR], 1.073; 95% confidence interval [CI], 1.024-1.125; P = .003), HbSC genotype (aOR, 25.472; 95% CI, 3.788-171.285; P ≤ 0.001), and lower HbF (aOR, 0.786; 95% CI, 0.623-0.993; P = .043) were associated with PSCR at end of follow-up. Lack of any SCR at end of follow-up was associated with female sex (aOR, 2.555; 95% CI, 1.101-5.931; P = .029), HbSS/HbSβ0/HbSβ+ genotype (aOR, 3.733; 95% CI, 1.131-12.321; P = .031), and higher HbF levels (aOR, 1.119; 95% CI, 1.007-1.243; P = .037). Differentiated strategies for screening and follow-up of SCR could be considered for patients at low or high risk.
The Allele Catalog Tool: a web-based interactive tool for allele discovery and analysis
Authors: Chan Yen On , Dietz Nicholas , Zeng Shuai , Wang Juexin , Flint-Garcia Sherry , Salazar-Vidal M. Nancy , Škrabišová Mária , Bilyeu Kristin , Joshi Trupti 
Published: March 2023

Abstract
Background
The advancement of sequencing technologies today has made a plethora of whole-genome re-sequenced (WGRS) data publicly available. However, research utilizing the WGRS data without further configuration is nearly impossible. To solve this problem, our research group has developed an interactive Allele Catalog Tool to enable researchers to explore the coding region allelic variation present in over 1,000 re-sequenced accessions each for soybean, Arabidopsis, and maize.

Results
The Allele Catalog Tool was designed originally with soybean genomic data and resources. The Allele Catalog datasets were generated using our variant calling pipeline (SnakyVC) and the Allele Catalog pipeline (AlleleCatalog). The variant calling pipeline is developed to parallelly process raw sequencing reads to generate the Variant Call Format (VCF) files, and the Allele Catalog pipeline takes VCF files to perform imputations, functional effect predictions, and assemble alleles for each gene to generate curated Allele Catalog datasets. Both pipelines were utilized to generate the data panels (VCF files and Allele Catalog files) in which the accessions of the WGRS datasets were collected from various sources, currently representing over 1,000 diverse accessions for soybean, Arabidopsis, and maize individually. The main features of the Allele Catalog Tool include data query, visualization of results, categorical filtering, and download functions. Queries are performed from user input, and results are a tabular format of summary results by categorical description and genotype results of the alleles for each gene. The categorical information is specific to each species; additionally, available detailed meta-information is provided in modal popups. The genotypic information contains the variant positions, reference or alternate genotypes, the functional effect classes, and the amino-acid changes of each accession. Besides that, the results can also be downloaded for other research purposes.

Conclusions
The Allele Catalog Tool is a web-based tool that currently supports three species: soybean, Arabidopsis, and maize. The Soybean Allele Catalog Tool is hosted on the SoyKB website (https://soykb.org/SoybeanAlleleCatalogTool/), while the Allele Catalog Tool for Arabidopsis and maize is hosted on the KBCommons website (https://kbcommons.org/system/tools/AlleleCatalogTool/Zmays and https://kbcommons.org/system/tools/AlleleCatalogTool/Athaliana). Researchers can use this tool to connect variant alleles of genes with meta-information of species.
Estimating sensitivity and specificity of diagnostic tests using latent class models that account for conditional dependence between tests: a simulation study
Authors: Keddie Suzanne H. , Baerenbold Oliver , Keogh Ruth H. , Bradley John 
Published: March 2023

AbstractBackgroundLatent class models are increasingly used to estimate the sensitivity and specificity of diagnostic tests in the absence of a gold standard, and are commonly fitted using Bayesian methods. These models allow us to account for ‘conditional dependence’ between two or more diagnostic tests, meaning that the results from tests are correlated even after conditioning on the person’s true disease status. The challenge is that it is not always clear to researchers whether conditional dependence exists between tests and whether it exists in all or just some latent classes. Despite the increasingly widespread use of latent class models to estimate diagnostic test accuracy, the impact of the conditional dependence structure chosen on the estimates of sensitivity and specificity remains poorly investigated.MethodsA simulation study and a reanalysis of a published case study are used to highlight the impact of the conditional dependence structure chosen on estimates of sensitivity and specificity. We describe and implement three latent class random-effect models with differing conditional dependence structures, as well as a conditional independence model and a model that assumes perfect test accuracy. We assess the bias and coverage of each model in estimating sensitivity and specificity across different data generating mechanisms.ResultsThe findings highlight that assuming conditional independence between tests within a latent class, where conditional dependence exists, results in biased estimates of sensitivity and specificity and poor coverage. The simulations also reiterate the substantial bias in estimates of sensitivity and specificity when incorrectly assuming a reference test is perfect. The motivating example of tests for Melioidosis highlights these biases in practice with important differences found in estimated test accuracy under different model choices.ConclusionsWe have illustrated that misspecification of the conditional dependence structure leads to biased estimates of sensitivity and specificity when there is a correlation between tests. Due to the minimal loss in precision seen by using a more general model, we recommend accounting for conditional dependence even if researchers are unsure of its presence or it is only expected at minimal levels.
Acceptability of patient-centered, multi-disciplinary medication therapy management recommendations: results from the INCREASE randomized study
Authors: Smith Noah I. , Martinez Ashley I. , Huffmyer Mark , Eckmann Lynne , George Rosmy , Abner Erin L. , Jicha Gregory A. , Moga Daniela C. 
Published: March 2023

Abstract
Background
Polypharmacy and inappropriate medications may be a modifiable risk factor for Alzheimer’s Disease and Related Dementias (ADRD). Medication therapy management (MTM) interventions may mitigate medication-induced cognitive dysfunction and delay onset of symptomatic impairment. The objective of the current study is to describe an MTM protocol for a patient-centered team intervention (pharmacist and non-pharmacist clinician) in a randomized controlled trial (RCT) directed at delaying the symptomatic onset of ADRD.

Methods
Community dwelling adults 65 + years, non-demented, using ≥ 1 potentially inappropriate medications (PIM) were enrolled in an RCT to evaluate the effect of an MTM intervention on improving medication appropriateness and cognition (NCT02849639). The MTM intervention involved a three-step process: (1) pharmacist identified potential medication-related problems (MRPs) and made initial recommendations for prescribed and over-the-counter medications, vitamins, and supplements; (2) study team reviewed all initial recommendations together with the participants, allowing for revisions prior to the finalized recommendations; (3) participant responses to final recommendations were recorded. Here, we describe initial recommendations, changes during team engagement, and participant responses to final recommendations.

Results
Among the 90 participants, a mean 6.7 ± 3.6 MRPs per participant were reported. Of the 259 initial MTM recommendations made for the treatment group participants (N = 46), 40% percent underwent revisions in the second step. Participants reported willingness to adopt 46% of final recommendations and expressed need for additional primary care input in response to 38% of final recommendations. Willingness to adopt final recommendations was highest when therapeutic switches were offered and/or with anticholinergic medications.

Conclusion
The evaluation of modifications to MTM recommendations demonstrated that pharmacists’ initial MTM recommendations often changed following the participation in the multidisciplinary decision-making process that incorporated patient preferences. The team was encouraged to see a correlation between engaging patients and a positive overall response towards participant acceptance of final MTM recommendations.

Trial registration
Study registration number: clinicaltrial.gov NCT02849639 registered on 29/07/2016.
Association between triglyceride glucose index and sleep disorders: results from the NHANES 2005–2008
Authors: Pei Heng , Li Shuyu , Su Xin , Lu Yangyang , Wang Zhijun , Wu Shouling 
Published: March 2023

Abstract
Background
To determine the association between sleep disorders and Triglyceride glucose index.

Methods
A cross-sectional analysis of the 2005 to 2008 National Health and Nutrition Examination Survey (NHANES) was performed. The 2005 to 2008 NHANES national household survey for adults ≥ 20 years was examined for the sleep disorders.TyG index: ln [triglyceride (mg/ dL) × fasting blood glucose (mg/dL)/2].Multivariable logistic and linear regression models were used to explore the association between the TyG index and sleep disorders.

Results
A total of 4,029 patients were included. Higher TyG index is significantly associated with elevated sleep disorders in U.S. adults. TyG was moderately correlated with HOMA-IR (Spearman r = 0.51). TyG was associated with higher odds of sleep disorders(adjusted OR [aOR],1.896; 95% CI, 1.260 2.854), Sleep apnea (aOR, 1.559; 95% CI, 0.660 3.683), Insomnia(aOR, 1.914;95% CI, 0.531 6.896), and Restless legs (aOR, 7.759; 95% CI,1.446 41.634).

Conclusions
In this study, our result shown that population with higher TyG index are significantly more likely to have sleep disorders in U.S. adults.