bluuebunny/crossref_metadata_2025_split huggingface dataset:
A goal‐oriented hemodynamic approach to acute myocardial infarction complicated by cardiogenic shock—A single center experience
Authors: Siebert Vince , Goldstein Jake , Khan Rizwan , Lopez John , Darki Amir , Lewis Bruce , Steen Lowell , Doukas Demetrios 
Published: August 2023

AbstractBackgroundAcute myocardial infarction complicated by cardiogenic shock (AMI‐CS) is the most common cause of mortality following AMI, and treatment algorithms vary widely. We report the results of an analysis using time‐sensitive, hemodynamic goals in the treatment of AMI‐CS in a single center study.MethodsConsecutive patients with AMI‐CS from November 2016 through December 2021 were included in our retrospective analysis. Clinical characteristics and outcomes were analyzed using the electronic medical records. We identified 63 total patients who were admitted to our center with AMI‐CS, and we excluded patients who did not have clear timing of AMI onset or CS onset. We evaluated the rate of survival to hospital discharge based on the quantity of certain time‐sensitive hemodynamic goals were met.ResultsWe identified 63 patients who met criteria for AMI‐CS, 39 (62%) of whom survived to hospital discharge. Odds of survival were closely related to the achievement of four time‐dependent goals: cardiac power output (CPO) >0.6 Watts (W), pulmonary artery pulsatility index (PAPi) >1, lactate <4 mmol/L, and <2 vasopressors required. Of the 63 total patients, 36 (57%) received intra‐aortic balloon pump (IABP) and 18 (29%) received an Impella CP (Abiomed) as an initial mechanical circulatory support strategy. Six patients were escalated from IABP to Impella CP for additional hemodynamic support. Nine patients were treated with vasopressors/inotropes alone. Regarding the 39 patients who survived to hospital discharge, 75% of patients met 3 or 4 goals at 24 h, whereas only 16% of deceased patients met 3 or 4 goals at 24 h. Of the 24 patients who did not survive to hospital discharge, 18 (75%) met either 0–1 goal at 24 h. There was no effect of the initial treatment strategy on achieving 3–4 goals at 24 h.ConclusionOur study evaluated the association of meeting 4 time‐sensitive goals (CPO >0.6 W, PAPi >1, <2 vasopressors, and lactate <4 mmol/L) at 24 h after treatment for AMI‐CS with in‐hospital mortality. Our data show, in line with previous data, that the higher number of goals met at 24 h was associated with improved in‐hospital mortality regardless of treatment strategy.
Renal denervation in hypertension: An updated meta‐analysis of the randomized controlled trials
Authors: Singh Sahib , Rout Amit , Garg Aakash 
Published: August 2023

AbstractBackgroundRadiofrequency or ultrasound renal denervation (RDN) has shown conflicting results when used as an adjunctive option for hypertension management in randomized controlled trials (RCTs).MethodsWe searched Pubmed, MEDLINE, and other online databases for RCTs comparing RDN versus sham‐control procedures in patients with uncontrolled or resistant hypertension. The endpoints of interest were 24‐h ambulatory (AMB) blood pressure (BP), daytime AMB BP, and office BP. We performed a random‐effects meta‐analysis using the inverse variance method to estimate mean difference (MD) with a 95% confidence interval (CI).ResultsNine studies with 1643 patients were included in the final analysis. The mean follow‐up was 5 months. As compared with the sham‐controlled group, RDN was associated with a significant decrease in 24‐h AMB BP (systolic [MD −4.20; 95% CI −5.36 to −3.03; p < 0.00001], diastolic [−2.38; −3.42 to −1.35]), and daytime AMB BP (systolic: −5.11; −6.75 to −3.47, diastolic: −2.88; −3.91 to −1.85). Similarly, office BP was reduced with RDN (systolic: −5.46; −7.12 to −3.81; diastolic: −3.17; −4.23 to −2.12) when compared with placebo.ConclusionOur meta‐analysis shows that RDN is associated with a significant reduction in the 24‐h AMB BP, daytime AMB BP, and office BP.
Abscess after cardiac pacemaker implantation: A case report
Authors: Rybak‐d'obyrn Joanna , Machoń Natalia Joanna , Lewandowska Julia Alicja , Owczarczyk‐Saczonek Agnieszka , Placek Waldemar 
Published: August 2023

AbstractThis is a report of one of the most serious complications of the cardiac pacemaker implantation ‐ infection of the implanted system. We present the case, which was misdiagnosed at the beginning and after cardiological consultation it was decided to immediately remove the peacemaker and transfer the patient to the Cardiological Department.
Subcapsular renal transplant hematoma mimicking acute tubular necrosis
Authors: Rhea Akel , Elias Haddad , Kamal Hachem 
Published: August 2023

Key Clinical MessageKidney transplantation is the treatment of choice for patients with end‐stage renal disease. However, it is associated with serious potential complications, one of which is the subcapsular renal transplant hematoma. Ultrasound is the major imaging tools in the evaluation of early graft complications. We discuss the case of a patient who underwent a living‐donor kidney transplantation, complicated of acute kidney injury documented on serial blood tests with an elevation of creatinine levels and oliguria. Ultrasonography showed the presence of a subcapsular renal hematoma, associated with the same spectral characterizations of an acute tubular necrosis with a high resistive index on Color Doppler Ultrasonography Study of renal arteries. The patient underwent an emergent surgical evacuation of the subcapsular renal hematoma. A repeat ultrasonography showed the complete resolution of the subcapsular renal hematoma with normal resistive index. During the following days, diuresis was back to normal and serial blood tests showed normal levels of creatinine. This case report highlights the importance of Ultrasonography in detecting subcapsular hematomas that could be a reversible cause of acute kidney injury and acute tubular necrosis in the setting of renal transplant.
An atypical presentation of giant cell arteritis: Fatigable signs to anterior ischemic optic neuropathy and choroidal infarction
Authors: Shinbashi Meagan , Hakim Summer , Mechel Elzbieta , Mehta Mitul C. , Crow Robert W. 
Published: August 2023

Key Clinical MessagePrompt diagnosis and treatment of GCA are crucial to preserve vision. Because of this, new‐onset ptosis or diplopia in elderly patients should warrant consideration of GCA, even in the absence of “classic” features, systemic symptoms or elevated inflammatory markers.AbstractGiant cell arteritis (GCA) is a vision‐threatening, ophthalmic emergency that classically presents with new‐onset headaches, scalp tenderness, systemic symptoms, visual disturbances, and elevated inflammatory markers. We describe an atypical presentation of GCA in an 87‐year‐old patient with fatigable ptosis and diplopia, with subsequent anterior ischemic optic neuropathy and choroidal infarction.
In chronic spontaneous urticaria, IgE and C‐reactive protein are linked to distinct microRNAs and interleukin‐31
Authors: Karstarli Bakay Ozge Sevil , Demir Betül , Cicek Demet , Erol Deniz , Aşçı Toraman Zulal , Gural Yunus , Maurer Marcus 
Published: August 2023

AbstractBackgroundChronic spontaneous urticaria (CSU) is a common and disabling disease. Assessments of IgE and C‐reactive protein (CRP) are recommended in the diagnostic work‐up, but the role and clinical relevance of these biomarkers are not well characterized. Moreover, it remains unknown if elevated levels of IgE or CRP are linked to CSU microRNA (miRNA) signatures or interleukin 31 (IL‐31).MethodsWe measured IgE and CRP serum levels in 47 CSU patients (and 45 healthy controls) and determined CSU disease activity using the urticaria activity score (UAS7). Expression levels of miR‐155 and miR‐221 were assessed by RT‐PCR, and IL‐31 levels were determined by ELISA.ResultsTotal IgE and CRP levels were independently increased in CSU patients. IgE and CRP levels were highest and lowest in patients with high and mild disease activity. IgE levels correlated with miR‐155 levels, whereas CRP levels correlated with miR‐221 levels. miR‐155 and miR‐221 were significantly overexpressed in CSU patients. ROC analyses linked miRNA‐155 and CSU with a sensitivity of 79% and specificity of 87%, and miRNA‐221 and CSU with a sensitivity of 75% and specificity of 91%. High CRP and miR‐221 expression levels were linked to elevated levels of IgG anti‐TPO and IL‐31.ConclusionIgE and CRP are useful biomarkers for disease activity in CSU, with distinct miRNA profiles. High CRP and miR‐221 levels may point to autoimmune CSU and a role for IL‐31.
DL‐DC: Deep learning‐based deadline constrained load balancing technique
Authors: Champla Dharavath , Dhandapani Sivakumar , Velmurugan Nagarajan 
Published: August 2023

SummaryLoad balancing is a crucial feature of cloud computing that evenly distributes workload between servers, network interfaces, and hard drives. Because of dynamic computing over the internet, cloud computing suffers from request overloading. To address this challenge, this paper proposes a new deep learning‐based deadline constrained (DL‐DC) load balancing technique. The proposed DL‐DC technique will improve resource utilization, reduce cost, latency, and response time, as well as balance load between servers and improve reliability. The proposed DL‐DC technique will direct traffic to a load balancer, which will forward the load with a deadline to a deep Inception ResNet. This network considers some parameters, such as sticky session, content‐based and instance health check and efficiently predicts the schedule for the task. Finally, a predicted task schedule has been derived using the DL‐DC model which is used to distribute the task to the virtual machine. The proposed DL‐DC load balancing algorithm is compared with other existing algorithms such as QMPSO, DQTS, and ACSO in terms of cost, makespan, response time, transmission time and task migration. The proposed method achieves up to 21.08% low response time, 27.3% decrease in make span, 25.5% decrease in task migration, and 38.9% decrease in cost respectively.
A scalable parallel algorithm for global sequence alignment with customizable scoring scheme
Authors: Sadiq Muhammad Umair , Yousaf Muhammad Murtaza 
Published: August 2023

SummarySequence alignment is a critical computational problem in various domains, including genomics, proteomics, and natural language processing. The Needleman‐Wunsch (NW) algorithm is a classical dynamic programming approach for finding the optimal global alignment between two sequences. However, its quadratic time and space complexity make it impractical for aligning large‐scale sequences, which are increasingly common in modern applications. In this article, we propose a parallel variation of the NW algorithm that enables scalable global sequence alignment with customizable scoring schemes. Our approach re‐formulates the dependencies in the NW algorithm to enable parallel execution, thereby leveraging the computational power of modern parallel architectures, such as graphics processing unit (GPU). Furthermore, our algorithm supports arbitrary linear scoring schemes, which allows us to use domain‐specific knowledge to improve alignment accuracy. We establish the correctness of our algorithm and evaluate its performance using real DNA and user trajectory sequences on GPUs. Our parallel algorithm has shown impressive results in our experiments, with a peak performance of 27.99 GCUPS (giga cell updates per second) and a maximum speedup of 48.18 times compared to the traditional sequential implementation. Additionally, our algorithm demonstrates remarkable scalability, enabling the alignment of sequences of any length while ensuring balanced work distribution and optimal utilization of resources. Our primary objective is to harness the computational capabilities of a single GPU and fully utilize the processing power of multi‐core CPUs.
Raman Spectroscopy of Formamidinium‐Based Lead Mixed‐Halide Perovskite Bulk Crystals
Authors: Ghosh Supriya , Rana Debkumar , Pradhan Bapi , Donfack Patrice , Hofkens Johan , Materny Arnulf 
Published: August 2023

AbstractIn recent years, there has been an impressively fast technological progress in the development of highly efficient lead halide perovskite solar cells. Nonetheless, the stability of perovskite films and associated solar cells remains a source of uncertainty and necessitates sophisticated characterization techniques. Here, we report low‐ to mid‐frequency resonant Raman spectra of formamidinium‐based lead mixed‐halide perovskites. The assignment of the different Raman lines in the measured spectra is assisted by DFT simulations of the Raman spectra of suitable periodic model systems. An important result of this work is that both experiment and theory point to an increase of the stability of the perovskite structure with increasing chloride doping concentration. In the Raman spectra, this is reflected by the appearance of new lines due to the formation of hydrogen bonds. Thus, higher chloride doping results in less torsional motion and lower asymmetric bending contributing to higher stability. This study yields a solid basis for the interpretation of the Raman spectra of formamidinium‐based mixed‐halide perovskites, furthering the understanding of the properties of these materials, which is essential for their full exploitation in solar cells.
Green Additives in Chitosan‐Based Bioplastic Films: Physical, Mechanical, and Chemical Properties
Authors: Schnabl Kordula B. , Mandemaker Laurens D. B. , Nierop Klaas G. J. , Deen Olivier V. B. , Eefting Desmond D. , Vollmer Ina , Weckhuysen Bert M. 
Published: August 2023

AbstractTo switch to alternatives for fossil‐fuel‐based polymer materials, renewable raw materials from green resources should be utilized. Chitosan is such a material that is a strong, but workable derivative from chitin, obtained from crustaceans. However, various applications ask for specific plastic properties, such as certain flexibility, hardness and transparency. With different additives, also obtainable from green resources, chitosan‐based composites in the form of self‐supporting films, ranging from very hard and brittle to soft and flexible were successfully produced. The additives turned out to belong to one of three categories, namely linear, non‐linear, or crosslinking additives. The non‐linear additives could only be taken up to a certain relative amount, whereas the uptake of linear additives was not limited within the range of our experiments. Additives with multiple functional groups tend to crosslink chitosan even at room temperature in an acidic medium. Finally, it was shown that dissolving the chitosan in acetic acid and subsequently drying the matrix as a film results in reacetylation compared to the starting chitosan source, resulting in a harder material. With these findings, it is possible to tune the properties of chitosan‐based polymer materials, making a big step towards application of this renewable polymer within consumer goods.
Study and implementation of fluxgate current sensor with wireless connectivity for finger exoskeleton rehabilitation
Authors: Lin Wei‐Cheng , Wu Ching‐Yi , Liao Chien‐Hung , Hsieh Chun‐Ting , Zeng Ren‐Jie , Hsieh Yun‐Yu , Hou Peng‐Ru 
Published: August 2023

SummaryA fully integrated fluxgate magnetometer has been developed to monitor motor current in a finger exoskeleton device. The use of a fluxgate sensor can provide more accurate and natural movement of the fingers, as well as reducing the weight and complexity of the exoskeleton design. The sensor we developed incorporates several advanced features that provide enhanced sensitivity and accuracy compared to existing state‐of‐the‐art sensors. These features include a fluxgate frontend readout circuit with chopping stabilization technology, which achieves a gain of 14.3 V/T, a low noise density of 4.5 nT/√Hz, and a wide measurement range of ±1.5 mT. The gain variation of the sensor is only 1.5% at an 850 kHz bandwidth, and it has a wide dynamic current range from 0.005 mA to 100 A. The sensor also features an integrated 2.4 GHz wireless circuit for easy data transmission. The use of a fluxgate sensor in monitoring motor torque in the proximal interphalangeal joint can provide more precise and natural finger movement and reduce the weight and complexity of the exoskeleton design.
Design and implementation of analog tracking filter for ac signal acquisition
Authors: Hu Hongjun , Shen Haikuo 
Published: August 2023

SummaryThis paper presents an analog tracking bandpass filter that is intended to be applied in ac signal acquisition circuits to reduce measurement noise. A fast and accurate frequency tuning technique is developed based on the phase control loop. A complete derivation process is provided to build the mathematical model describing the control loop for the tracking filter. Accordingly, a zero‐crossing detector is designed to accurately extract signal phases in the proposed loop. As a closed‐loop control system, the loop dynamics such as stability, transient response, and steady‐state error are analyzed using the derived model. From both the simulations and measurements, the developed filter is found to provide excellent performance in frequency tracking, noise reduction, and linearity compared to existing work. The maximum and minimum Q value reaches 42.2 and 14, respectively, in the frequency tuning range of 34 to 107 kHz, while the frequency tracking error is less than 1.18% at 100 kHz.
Preliminary study of finger temperature recovery in patients with diabetes mellitus following cold stimulation
Authors: Zhang Wen‐zheng , Jiang Bi‐yao , Ye Chen , Xue Hui‐zhong , Yang Yi‐meng , Zhang Hua , Wang Guang‐lei , Luo Wen‐xuan , Xiao Yong‐hua , Mi Bao‐hong 
Published: August 2023

AbstractObjectiveTo explore the difference in temperature recovery following cold stimulation between participants with and without diabetes mellitus (DM).Materials and MethodsThe participants without (control group; n = 25) and with (DM group; n = 26) DM were subjected to local cold stimulation (10º C for 90 s). The thermal images of their hands were continuously captured using a thermal camera within 7 min following cold stimulation, and the highest temperature of each fingertip was calculated. According to the temperature values at different timepoints, the temperature recovery curves were drawn, and the baseline temperature (T‐base), initial temperature after cooling (T0), temperature decline amplitude (T‐range), and area under the temperature recovery curve > T0 (S) were calculated. Finally, symmetry differences between the two groups were analysed.ResultsNo statistical differences in the T‐base, T0, and T‐range were observed between the DM and control groups. After drawing the rewarming curve according to the temperature of the fingertips of the patients following cold stimulation, the S in the DM group was significantly lower than that in the control group (p < 0.05). Furthermore, the asymmetry of the base temperature of the hand was observed in the DM group.ConclusionsFollowing cold stimulation, the patients with DM exhibited a different rewarming pattern than those without DM. Thus, cold stimulation tests under infrared thermography may contribute to the early screening of diabetic peripheral neuropathy in future.
Causal discovery analysis: A promising tool in advancing precision medicine for eating disorders
Authors: Anderson Lisa M. , Lim Kelvin O. , Kummerfeld Erich , Crosby Ross D. , Crow Scott J. , Engel Scott G. , Forrest Lauren , Wonderlich Stephen A. , Peterson Carol B. 
Published: August 2023

AbstractObjectivePrecision medicine (i.e., individually tailored treatments) represents an optimal goal for treating complex psychiatric disorders, including eating disorders. Within the eating disorders field, most treatment development efforts have been limited in their ability to identify individual‐level models of eating disorder psychopathology and to develop and apply an individually tailored treatment for a given individual's personalized model of psychopathology. In addition, research is still needed to identify causal relationships within a given individual's model of eating disorder psychopathology. Addressing this limitation of the current state of precision medicine‐related research in the field will allow us to progress toward advancing research and practice for eating disorders treatment.MethodWe present a novel set of analytic tools, causal discovery analysis (CDA) methods, which can facilitate increasingly fine‐grained, person‐specific models of causal relations among cognitive, behavioral, and affective symptoms.ResultsCDA can advance the identification of an individual's causal model that maintains that individuals' eating disorder psychopathology.DiscussionIn the current article, we (1) introduce CDA methods as a set of promising analytic tools for developing precision medicine methods for eating disorders including the potential strengths and weaknesses of CDA, (2) provide recommendations for future studies utilizing this approach, and (3) outline the potential clinical implications of using CDA to generate personalized models of eating disorder psychopathology.Public Significance StatementCDA provides a novel statistical approach for identifying causal relationships among variables of interest for a given individual. Person‐specific causal models may offer a promising approach to individualized treatment planning and inform future personalized treatment development efforts for eating disorders.
The effects of N‐addition on litter mixture effects depend on decomposition time: A case from mixed‐litter decomposition in the Gurbantunggut Desert
Authors: Zhao Hong‐Mei , Yang Wei‐Jun , Cheng Jun‐Hui , Huang Gang , Hu Yu‐Tong , Li Cong‐Juan , Sheng Jian‐Dong 
Published: August 2023

AbstractChanges in nitrogen (N) deposition and litter mixtures have been shown to influence ecosystem processes such as litter decomposition. However, the interactive effects of litter mixing and N‐deposition on decomposition process in desert regions remain poorly identified. We assessed the simultaneous effects of both N addition and litter mixture on mass loss in a litterbag decomposition experiment using six native plants in single‐species samples with diverse quality and 14‐species combinations in the Gurbantunggut Desert under two N addition treatments (control and N addition). The N addition had no significant effect on decomposition rate of single‐species litter (expect Haloxylon ammodendron), whereas litter mass loss and decomposition rate differed significantly among species, with variations positively correlated with initial phosphorus concentration and negatively correlated with initial lignin concentration. After 18 months, the average mass loss across litter mixtures did not overall differ from those predicted from single species either in control or N addition treatments, that is, mixing of different species had no non‐additive effects on decomposition. The N addition, however, did modify the direction of mixture effects and interacted with incubation time. Added N transformed synergistic effects of litter mixtures to antagonistic effects on mass loss after 1 month of decomposition, while transforming neutral effects of litter mixture to synergistic effects after 6 months of decomposition. Our results demonstrated that initial chemical properties played an important role in litter decomposition, while no effects of litter mixture on decomposition process in this desert region. The N addition altered the litter mixture effects on mass loss with incubation time, implying that increased N deposition in the future may have profound effects on carbon turnover to a greater extent than previously thought in desert ecosystems.