bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of Coconut Oil and its Bioactive Principles in Alzheimer’s disease and Dementia: A Systematic Review and Meta-Analysis
Authors: Bafail Duaa , Bafail Abrar , Alshehri Norah Farraj , Alhalees Noura Hamdi , Bajarwan Ahmad 
Published: September 2023

Abstract
BACKGROUND: As the older population increases, Alzheimer's disease and dementia cause substantial problems to healthcare systems worldwide, demanding efficient preventative and treatment measures. Alzheimer's disease (AD), the most common form of dementia, affects approximately 50 million people worldwide. Interest in coconut oil as a potential dietary intervention has grown due to its high content of medium-chain triglycerides (MCTs), which are metabolized to ketone bodies and might serve as a substitute for glucose in the brain, sustain cognitive function, and possibly reduce the progression of Alzheimer’s disease.METHOD: Relevant research articles published between January 2015 and June 2023 were searched in the Cochrane Central Register of Controlled Trials (CENTRAL), Science Direct, Scopus, Google Scholar, and PubMed (MEDLINE) databases using multiple search strategies. Only studies on human subjects that assessed the impact of coconut oil and its bioactive components on cognitive function and dementia in patients with AD were included. Four publications met the eligibility criteria. The review was conducted according to the PRISMA guidelines. A meta-analysis was performed to evaluate the summary standard mean (SM) and 95% confidence intervals (CIs). The Forest Plot was generated using Review Manager 5.3 (RevMan 5.3).RESULTS: The analysis revealed that all studies showed consistent results regarding the effect of coconut oil on cognitive scores, with little variability in the true effects of coconut oil on cognitive scores across the studies included in the meta-analysis.CONCLUSION: We concluded that coconut oil improved cognitive scores in patients with Alzheimer's disease compared to those in the control group (p < 0.05). The results of this study add to the increasing amount of evidence indicating that medium-chain triglycerides (MCTs) found in coconut oil might be a way to improve abilities and potentially slow down the advancement of Alzheimer’s disease. The findings of this study could encourage the development of targeted dietary strategies and interventions for individuals at risk for or diagnosed with Alzheimer's disease.SYSTEMATIC REVIEW REGISTRATION: The review protocol was registered in PROSPERO (CRD42023450435).
Status, challenges and opportunities of landslide susceptibility assessment in China: the perspective from national bibliometric analysis and global comparison for hazard mitigation
Authors: Xiong Hanxiang , Wang Yuzhou , Tan Jiayao , Xiong Ruihan , Yang Shilong , Ma Chuanming 
Published: September 2023

Abstract
Landslide susceptibility assessment (LSA) is a crucial step for landslide risk management, hazard mitigation, land use planning, and sustainable development. In this study, we conducted a bibliometric analysis of LSA literature in China and compared it with global trends, aiming to identify the status, challenges and opportunities of LSA in China. We created a database of 337 peer-reviewed LSA articles in China, analysing ten aspects, including temporal trends, journals, authors, institutions, keywords, study areas, inventory information, landslide factors, models, and evaluation metrics. Our results show that China is a leading contributor to LSA research, with top contributors being Environmental Earth Science, Chen Wei, and China University of Geoscience. Over 90% of the articles used a single inventory for assessment, primarily derived from field mapping and aerial photograph interpretation. Slope, geo-lithology, and aspect were identified as key factors in landslide occurrence in China, and machine learning models have become the mainstream methods for LSA. ROC curves were the most used evaluation metric. Priority regions for landslide management in China include Hunan, Fujian, and Guangxi. By global comparisons, concerns remain about the impact of LSA articles, engagement with global issues, landslide inventory quality, suitability of machine learning models, factor selection, and evaluation metric reliability. According to the gaps between global and China, we identified six challenges and opportunities, including technology R&D, landslide factor determination, hybrid model development, comprehensive evaluation systems, responses to climate change and human activity, and the shift from susceptibility to management and sustainable development. Recommendations addressing these challenges are also provided, and a general framework for assessing the challenges and opportunities in LSA for any other country or other fields is provided. It is able to support decision-makers in making more informed decisions.
Synchronous recording of magnetocardiographic and electrocardiographic signals
Authors: Pęczalski Kazimierz , Sobiech Judyta , Buchner Teodor , Kornack Thomas , Foley Elizabeth , Janczak Daniel , Jakubowska Małgorzata , Newby David , Ford Nancy , Zajdel Maryla 
Published: September 2023

Abstract
We present a system for simultaneous recording of the electrocardiogram and the magnetocardiogram. The measurement system contained of printed carbon electrodes and SERF magnetometer. The use of this system confirms that the position of the end of the magnetic T wave extends further than the electric T wave, which is an important indicator for the diagnosis of cardiological patients and for drug arrhythmogenicity. We analyze this phenomenon in depth, and demonstrate, that it originates from the fundamental difference between electric and magnetic measurements. The measured value is always bipolar since the electric measurements require two electrodes. We demonstrate how the dual electric and magnetic measuring system adds a new information to the commonly used electrocardiographic diagnosis. The ECG should be interpreted as the spatial asymmetry of the electric cardiac potential, and not as the potential itself. The results seem to prove, that the relation between the magnetic and the electric imaging of neural activities may be broadly applied for the benefit of medical diagnosis in cardiology and many other fields, where the neural activity is measured. This is a pilot study which requires further confirmation at the clinical level.
Exploration of a Hypoxia-Immune-Related Microenvironment Gene Signature and Prediction Model for Hepatitis C-induced Early-stage Fibrosis
Authors: Chen Chu Wen , Cai Haozheng , Shen Junyi , Zhang Xiaoyun , Peng Wei , Li Chuan , Lv Haopeng , Wen Tianfu 
Published: September 2023

Abstract
Background: Liver fibrosis contributes to significant morbidity and mortality in Western nations, primarily attributed to chronic hepatitis C virus (HCV) infection. Hypoxia and immune status have been reported to be significantly correlated with the progression of liver fibrosis. The current research aimed to investigate the gene signature related to the hypoxia-immune-related microenvironment and identify potential targets for liver fibrosis.
Method: Sequencing data obtained from GEO were employed to assess the hypoxia and immune status of the discovery set utilizing UMAP and ESTIMATE methods. The prognostic genes were screened utilizing the LASSO model. The infiltration levelof 22 types of immune cells was quantified utilizing CIBERSORT, and a prognosis-predictive model was established per the selected genes. The model was also verified using qRT-PCR with surgical resection samples, including three liver transplantation donors, three individuals with liver fibrosis, and three individuals with hepatitis cirrhosis.
Results: Elevated hypoxia and immune status waslinked to an unfavorable prognosis in HCV-induced early-stage liver fibrosis. Increased plasma and resting NK cell infiltration was identified as a risk factor for liver fibrosis progression. Additionally, CYP1A2, CBS, GSTZ1, FOXA1, WDR72 and UHMK1 were determined as hypoxia-immune-related protective genes. The combined model effectively predicted patient prognosis. Furthermore, the preliminary validation of clinical samples supported most of the conclusions drawn from this study.
Conclusion: The prognosis-predictive model developed using six hypoxia-immune-related genes effectively predicts the prognosis and progression of liver fibrosis. The current study opens new avenues for the future prediction and treatment of liver fibrosis.
LSD1 regulates autophagy and apoptosis by acting through the PI3K/Akt/mTOR signaling pathway in spinal cord injury
Authors: Li Wenwen , Shi Tengbin , Zhou Linquan , Chen Zhi , Liu Wenge 
Published: September 2023

Abstract
The epigenetic enzyme lysine-specific demethylase 1 (LSD1) can negatively regulate autophagy in nerve injury diseases. Inhibition of LSD1 can enhance autophagy, attenuate apoptosis, and provide effective neuroprotection after spinal cord injury (SCI). However, existing studies have not fully interrogated the specific mechanisms through which LSD1 promotes autophagy and inhibits apoptosis. We tested if LSD1 induces autophagy and apoptosis of neurons after spinal cord injury by regulating the PI3K/Akt/mTOR signaling pathway by using differentiated PC12 cells in LSD1 gene knockdown and drug inhibition experiments. We found that LSD1 knockdown or inhibition decreased the expression of PI3K/Akt/mTOR-related proteins. Stimulation of LSD1 knockdown cells with the pathway activator IGF-1 increased the expression of LSD1, markedly attenuating the originally enhanced autophagy, and increasing apoptosis. We also showed an interaction between LSD1 and P-PI3K proteins using immunoprecipitation experiments.
A novel, multi-active emollient for the prevention of acute radiation dermatitis in breast cancer patients: A Randomized Clinical Trial
Authors: Robijns Jolien , Bever Leen Van , Hermans Sanne , Claes Marithé , Lodewijckx Joy , Lenaerts Melissa , Tuts Laura , Vandaele Eline , Vinken Evelien , Noé Leen , Verboven Katleen , Maes Annelies , De Velde Anne-Sophie Van , Bulens Paul , Bulens Philippe , Bergh Laura Van den , Mebis Jeroen 
Published: September 2023

Abstract
Purpose
To investigate the efficacy of a novel, multi-active emollient in preventing and managing acute radiation dermatitis (ARD) in breast cancer patients undergoing moderate hypofractionated (HF) radiotherapy (RT) compared to standard of care.
Methods
A monocentric, open-label, randomized clinical trial (RCT) with breast cancer patients receiving moderate HF (dose: 40.05-55.86Gy, fractions:15-21) was conducted between January 2022 and May 2023. The experimental group received the novel emollient, while the control group received the standard skin care. Patients applied the skin care products twice daily during the complete RT course. The primary outcome was the severity of ARD at the final RT session measured by the modified Radiation Therapy Oncology Group (RTOG) criteria. Secondary outcomes included patient symptoms, quality of life (QoL), and treatment satisfaction.
Results
A total of 100 patients with 50 patients per group were enrolled. In the control group, 50% of the patients developed RTOG grade 1 ARD and 48% grade 2 or higher, while in the experimental group, the severity of ARD was significantly lower with 82% grade 1 and 16% grade 2 ARD (P = .013, χ2-test). The frequency and severity of xerosis were significantly lower in the experimental compared to the control group (Ps ≤ .036, Mann Whiney U-test). The impact of ARD on the QoL was low, and treatment satisfaction was high in both groups, with no significant difference.
Conclusion
This RCT shows that the novel, multi-active emollient significantly reduced the ARD RTOG grade. Research in a more diverse patient population is warranted.
Trial registration number
ClinicalTrials.gov:NCT04929808(11/06/2021)
High Injury Prevalence in South African Adolescent Field Hockey Players: Implications for Future Practice
Authors: De Wit Dale , Ducray Jennifer Frances , Pillay Julian David 
Published: September 2023

Abstract

Background: Field hockey is a popular sport, globally. Due to the nature of hockey, players repeatedly perform a combination of forward flexion and rotational movements of the spine to strike the ball, predisposing them to pain/injury. This study aimed to determine the prevalence and incidence of Low Back Pain (LBP) in male adolescent field hockey players, its characteristics and association with selected risk factors, and treatment approaches.
Methods: A survey was conducted on 112 male adolescent field hockey players in the province of KwaZulu-Natal, South Africa. Sixty-eight questionnaires were completed (67% participation rate); period prevalence of LBP was 63.2% (35.0%: beginning of the season, 32.4%: mid-season, 22.1%: end-season); incidence was 38.2%.
Results: The most common location for LBP was the middle low back region (39.5%); the most common duration of pain was a few hours (32.6%). Most participants (79.1%) did not classify their pain as a disability; only 44.2% of participants received medical treatment.
Conclusions: The results of this study, although limited to a select group of adolescents, showed a higher prevalence of LBP than previous studies. More importantly, even though most participants did not experience LBP classified as a disability, LBP still had a large impact on participants, as nearly half of the participants consulted with a medical professional. A need for the application of further strategies in the prevention and management of LBP in field hockey such as adequate warm-up and cool-down, stretching exercises and rest between sessions are recommended as simple strategies to reduce LBP prevalence.
Energy relaxation in a vacuum capacitor-resistor circuit: measurement of sequential decays with divergent time constants
Authors: kowalski frank 
Published: September 2023

Abstract
The decay of the electrical energy in a resistor-vacuum capacitor circuit is shown to involve multiple sequential relaxation processes, with increasing time constants, separated by transition regions that involve a change in current direction. This is measured using a vacuum capacitor to eliminate the effect of a dielectric between the plates (although ceramic and polypropylene capacitors exhibit similar behavior). A simple phenomenological model accounts for this behavior in spite of the difficulty in applying Maxwell's equations to such a circuit. These results will lead to a revision of our understanding of the physics of circuits, having particular impact on applications that use capacitors as sensors in collecting precision data (such as found in quantum measurements and dielectric spectroscopy).
The Thermal Performance Off Different Construction Regulation in MOROCCO of the Building sector.
Authors: BENACHIR NOUHAILA , Farida Bendriaa , MOUHIB TAOUFIQ 
Published: September 2023

Abstract

The building envelope includes all the building components that separate the indoors from the outdoors. Building envelopes include the exterior walls, foundations, roof, windows and doors.
The performance of the building envelope is impacted by a number of sub-systems, such as heating, cooling and ventilating equipment, plumbing and electrical systems. The interaction of the sub‐systems with the components of the building envelope, as well as certain activities of the occupants, can affect the performance of the building envelope.
The building envelope should keep out: • temperature extremes • moisture, as vapour or liquid • dust • wind Additionally, to maintain durability, the building envelope should not permit weather elements to be trapped inside the walls. This may cause wall components to deteriorate, and continue to decay. In the early stages, it can usually be remedied relatively inexpensively. As time progresses, costs increase exponentially.
The objective of these simulations is to establish the optimal technical options to significantly improve the thermal performance of the target buildings compared to the current situation, considered as a reference. For this purpose, a series of thermal simulations were carried out on reference buildings using the TRNSYS software.choice of reference buildingsSeven reference buildings were chosen in consultation with the ministries in charge of the sectors concerned, to be the subject of thermal simulations:
Early maladaptive schemas in patients with chronic headache
Authors: YONTAR Gözde , OZGAN Esen 
Published: September 2023

Abstract
Background
Chronic headache is a serious clinical problem in women which psychological factors play major role and requires an approach with bio-psycho-social integrity. Psychiatric comorbidities such as anxiety disorder and major depression are frequent. Young described Early Maladaptive Schemas (EMS) as maladaptive and dysfunctional patterns that appear due to unpleasant situations occurred between patient and people who were important to him. EMSs affect perception, emotions, thoughts and behaviors that makes a basis for many disorders. EMSs are found to be related with depression, anxiety and somatization within recent literature. There is a lack of data about the relationship between EMSs and migraine (MH) and tension-type headache (TTH). Our study directly compared three groups, migraine and tension type headache and healthy controls.
Methods
150 female patients with chronic headache were enrolled for study in consecutive fashion. Exclusion criteria were as follows: age < 18 or > 60 years, male gender, existence of comorbidity affecting central nervous system, headache due to drug/substance abuse, previous diagnosis of migraine with aura, previous diagnosis of psychotic disease, mental retardation, cognitive disorders, being in delirium state. Patients were grouped into two categories according to type of headache and a third control group. All patients were evaluated with Young Schema Questionnaire (YSQ) and their scores were noted and categorized in related schema domains.
Results
Sociodemographic data were comparable among groups. However, there were significant differences in terms of previous psychiatric diagnosis and psychiatric drug usage. When we compared YSQ scores, groups differed in many schema categories. MH group showed significantly higher scores in dependency/incompetency, unrelenting standards and punitiveness schemas when compared to remaining two groups. TTH group had significantly more points in emotional deprivation, vulnerability to harm or illness schemas among all groups. On the other hand, control group had significantly higher scores in insufficient self-discipline and entitlement/grandiosity schemas when compared to both MH and TTH groups.
Conclusion
Presence of EMSs in female patients with headache significantly differed from control group. Types of early maladaptive schemas were also significantly different between patients with MH and TTH among this whole headache group.
FLAM: Locating and Mitigating 5GC Network Failure with Knowledge Graphs in China Telecom’s Network
Authors: Yu Peihua , Zhang Hua , Jiang Xiaofeng , Zhou Yi , Yan Xuechun , Zeng Qiang , Lin Yaoxin 
Published: September 2023

Abstract
China Telecom’s fifth-generation core (5GC) network is complicated owing to own characterizations of service based architecture and network functions vir-tualization, and thus is vulnerable of network failures. When a failure occurs, operations and maintenance (O&M) experts need to firstly analyze its root cause based on their professional experience; then recommending an available solution for the failure. However, 5GC network failures occur frequently, and most of them are similar; thus, inviting O&M experts to the 5GC network scene costs a super-long of time (hourly level) and wastes too much money. In this paper, we propose a knowledge&data-driven 5GC network Failure Location and Automated Mitigation (FLAM) mechanism. Particularly, FLAM illustrates the experts experience of different network failures using knowledge graphs. Four state-of-the-art machine learning algorithms are applied in FLAM to compare which one can better locate the root cause of network failures. Besides, a real-time checking module is designed to automatically diagnose the related network functions for network failures. Based on China Telecom’s real-wild data of network failures, the proposed mechanism is evaluated in the metrics of algorithm complexity and location accuracy. Experimental results show that the decision tree model has an accuracy of 99% for locating the root cause of network failures, which owns the best performance compared to the random forest, support vector machine, and k-nearest neighbor algorithms.
A Novel infrared spectroscopy biomarker to predict postoperative infection and sepsis in patients with upper urinary tract calculus
Authors: Lin Jiexiang , Yang Zesong , Hong Yun , Cai Wanghai , Pan Honghong , Hu Minxiong , Lin Jie , Ye Liefu 
Published: September 2023

Abstract
Background
Urinary tract infection, especially sepsis, is a common and severe postoperative complication for patients with upper urinary tract calculus (UUTC). Infrared wavelengths are widely used to identify calculus mineral composition, but their role in predicting postoperative infections remains unknown. This study aimed to develop an Infrared-infection score (IR-infection score) system based on calculi infrared wavelengths to indicate postoperative infection in UUTC patients.
Methods
From March 2018 to March 2023, 328 patients from Fujian Provincial Hospital South Branch were included in constructing the IR-infection score and nomogram, and 152 patients from Fujian Provincial Hospital were used as the validation cohort. Then IR-infection score was constructed based on infection-related infrared wavelengths by univariate and multivariate analysis. Continually, logistic regression with the stepwise backward method was used to build a nomogram. Afterward, the IR-infection score and nomogram were evaluated by the ROC curve, Hosmer-Lemeshow test, calibration curves, the decision curves. Finally, the Delong test was used to compare the predictive power of the IR-infection score with traditional indicators.
Results
Our study showed that the IR-infection score could precisely predict postoperative infection and sepsis in UUTC patients (postoperative infection: AUC construction cohort = 0.708, AUC validation cohort = 0.707; postoperative sepsis: AUC construction cohort = 0.690, AUC validation cohort = 0.824), with better predictive values than calculus composition and clinical indicators including blood white blood cell, procalcitonin, urine white blood cells, urine bacterial count, and urine culture. Moreover, the nomogram based on IR-infection score had high predictive power (all AUCs ＞ 0.8).
Conclusion
Our study first identified infrared wavelengths related to infection and offered new insights into extending the application of the infrared spectrum in predicting postoperative infection in UUTC patients.