bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between blood pressure recording in prehospital setting and patient outcome in pediatric trauma patients: A propensity score matching study
Authors: Shinohara Mafumi , Abe Takeru , Takeuchi Ichiro 
Published: July 2023

BACKGROUND
Rapid identification of the severity of injuries in the field is important to ensure appropriate hospital care for better outcomes. Vital signs are used as a field triage tool for critically ill or injured patients in prehospital settings. Several studies have shown that recording vital signs, especially blood pressure, in pediatric patients is sometimes omitted in prehospital settings compared with that in adults. However, little is known about the association between the lack of measurement of prehospital vital signs and patient outcomes. In this study, we examined the association between the rate of vital sign measurements in the field and patient outcomes in injured children.

METHODS
This study analyzed secondary data from the Japan Trauma Data Bank. We included pediatric patients (0–17 years) with injuries who were transported by emergency medical services. Hospital survival was the primary outcome. We performed a propensity-matched analysis with nearest-neighbor matching without replacement by adjusting for demographic and clinical variables to evaluate the effect of recording vital signs.

RESULTS
During the study period, 13,413 pediatric patients were included. There were 9,187 and 1,798 patients with and without prehospital blood pressure records, respectively. After matching, there were no differences in the patient characteristics or disease severity. Hospital mortality was significantly higher in the nonrecorded group than in the recorded group (4.3% vs. 1.1%; p < 0.001). The multiple logistic regression analysis results showed no prehospital record of blood pressure being associated with death (odds ratio [OR], 6.82; 95% confidence interval [CI], 2.40–19.33). Glasgow Coma Scale score and Injury Severity Score were also associated with death (OR, 0.71; 95% CI, 0.63–0.81 and OR, 1.10; 95% CI, 1.06–11.14, respectively).

CONCLUSION
Pediatric patients without any blood pressure records in prehospital settings had higher mortality rates than those with prehospital blood pressure records.

LEVEL OF EVIDENCE
Therapeutic/Care Management; Level III.
Comprehensive multi-platform tyrosine kinase profiling reveals novel actionable FGFR aberrations across pediatric and AYA sarcomas
Authors: Fordham Ashleigh M , Brown Lauren M , Mayoh Chelsea , Salib Alice , Barger Zara A , Wong Marie , Sian Terry C.C. Lim Kam , Xie Jinhan , Gunther Kate , Trebilcock Peter , Terry Rachael L , Barahona Paulette , Ajuyah Pamela , Sherstyuk Alexandra , Avila Anica , Cadiz Roxanne , Perkins Callum M , Gifford Andrew J , Mao Jie , Zhao Andrea , O’Regan Luke P , Gorgels Daniel , Lau Loretta MS , Ziegler David S , Haber Michelle , Tyrrell Vanessa , Lock Richard B , Cowley Mark J , Nicholls Wayne , Daly Roger J , Ekert Paul G , Fleuren Emmy DG 
Published: July 2023

AbstractNo targeted agents are approved for pediatric sarcomas. Tyrosine kinase (TK) inhibitors represent attractive therapeutic candidates, however, beyond rare TK-activating fusions or mutations, predictive biomarkers are lacking. RNA overexpression of TKs is more commonly observed in pediatric sarcomas, however, an unresolved question is when upregulated TK expression is associated with kinase activation and signaling dependence. We explored the TK molecular landscape of 107 sarcoma patients from the ZERO Childhood Cancer precision medicine program using whole genomic and transcriptomic sequencing. Phosphoproteomic analyses of tyrosine phosphorylation (pY) and functionalin vitroandin vivoassays were also performed in cell lines and patient-derived xenografts (PDXs). Our integrated analysis shows that although novel genomic driver lesions are rare, they are present and therapeutically actionable in selected patients as exemplified by a novelLSM1-FGFR1fusion identified in an osteosarcoma patient. We further show that in certain contexts, TK expression data can be used to indicate TK pathway activity and predict TK-inhibitor sensitivity. We exemplify the utility of FGFR-inhibitors inPAX3-FOXO1fusion-positive rhabdomyosarcomas (FP-RMS) mediated by highFGFR4andFGF8RNA expression levels, and overt activation of FGFR4 (FGFR4_pY). We demonstrate marked tumor growth inhibition in all FP-RMS PDXs treated with single agent FGF401 (FGFR4-specific inhibitor) and single agent lenvatinib (multi-kinase FGFR-inhibitor). Clinical benefit of lenvatinib in a relapsed metastatic FP-RMS patient further exemplifies that FGFR-inhibitors deserve additional investigation in FP-RMS patients.Statement of significanceOur multi-omic interrogation of sarcomas in the ZERO Childhood Cancer program illustrates how an RNA-expression biomarker signature (FGFR4+/FGF8+) in association with FGFR4 activation identifies thatPAX3-FOXO1-positive rhabdomyosarcoma patients could benefit from FGFR-inhibitors.
Unified fate mapping in multiview single-cell data
Authors: Weiler Philipp , Lange Marius , Klein Michal , Pe’er Dana , Theis Fabian J. 
Published: July 2023

AbstractSingle-cell RNA sequencing allows us to model cellular state dynamics and fate decisions using expression similarity or RNA velocity to reconstruct state-change trajectories. However, trajectory inference does not incorporate valuable time point information or utilize additional modalities, while methods that address these different data views cannot be combined and do not scale. Here, we present CellRank 2, a versatile and scalable framework to study cellular fate using multiview single-cell data of up to millions of cells in a unified fashion. CellRank 2 consistently recovers terminal states and fate probabilities across data modalities in human hematopoiesis and mouse endodermal development. Our framework also allows combining transitions within and across experimental time points, a feature we use to recover genes promoting medullary thymic epithelial cell formation during pharyngeal endoderm development. Moreover, we enable estimating cell-specific transcription and degradation rates from metabolic labeling data, which we apply to an intestinal organoid system to delineate differentiation trajectories and pinpoint regulatory strategies.
The SATB1-MIR22-GBA axis mediates glucocerebroside accumulation inducing a cellular senescence-like phenotype in dopaminergic neurons
Authors: Russo Taylor , Kolisnyk Benjamin , Bs Aswathy , Kim Tae Wan , Martin Jacqueline , Plessis-Belair Jonathan , Ni Jason , Pearson Jordan A. , Park Emily J. , Sher Roger B. , Studer Lorenz , Riessland Markus 
Published: July 2023

ABSTRACTIdiopathic Parkinson’s Disease (PD) is characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta, which is associated with neuroinflammation and reactive gliosis. The underlying cause of PD and the concurrent neuroinflammation are not well understood. In this study, we utilized human and murine neuronal lines, stem cell–derived dopaminergic neurons, and mice to demonstrate that three previously identified genetic risk factors for PD, namely SATB1, MIR22HG, and GBA, are components of a single gene regulatory pathway. Our findings indicate that dysregulation of this pathway leads to the upregulation of glucocerebrosides (GluCer), which triggers a cellular senescence-like phenotype in dopaminergic neurons. Specifically, we discovered that downregulation of the transcriptional repressor SATB1 results in the derepression of the microRNA miR-22-3p, leading to decreased GBA expression and subsequent accumulation of GluCer. Furthermore, our results demonstrate that an increase in GluCer alone is sufficient to impair lysosomal and mitochondrial function, thereby inducing cellular senescence dependent on S100A9 and stress factors. Dysregulation of the SATB1-MIR22-GBA pathway, observed in both PD patients and normal aging, leads to lysosomal and mitochondrial dysfunction due to the GluCer accumulation, ultimately resulting in a cellular senescence-like phenotype in dopaminergic neurons. Therefore, our study highlights a novel pathway involving three genetic risk factors for PD and provides a potential mechanism for the senescence-induced neuroinflammation and reactive gliosis observed in both PD and normal aging.
Microbial Respiration in Contrasting Ocean Provinces via High-Frequency Optical Assays
Authors: Cohn Melanie R. , Stephens Brandon , Meyer Meredith G. , Sharpe Garrett , Niebergall Alexandria K. , Graff Jason R. , Cassar Nicolas , Marchetti Adrian , Carlson Craig A. , Gifford Scott 
Published: July 2023

ABSTRACTMicrobial respiration plays a pivotal role in the marine carbon cycle, influencing the fraction of fixed carbon that undergoes remineralization versus export to depth. Despite its importance, methodological constraints have led to an inadequate understanding of this process, especially in low-activity oligotrophic and mesopelagic regions. Here, we quantify respiration rates as low as 0.2µmol O2 L-1d-1in contrasting ocean productivity provinces using optical oxygen sensors to identify size-fractionated respiration trends. At the low productivity North Pacific Ocean Station Papa, surface microbial respiration was relatively stable at 1.2µmol O2 L-1d-1. Below the surface there was a decoupling of respiration and bacterial production potentially driven by phytodetritus remineralization. Size-fractionated rates showed cells <5µm contributed the most to Pacific respiration. At the North Atlantic Porcupine Abyssal Plain, the optode measurement frequency was drastically increased. Surface microbial respiration was higher (1.7µmol O2 L-1d-1) and decreased by 3-fold below the euphotic zone. The Atlantic filtered fraction contributions to total respiration shifted with the phytoplankton bloom evolution. The high resolution optode method used in the Atlantic is consistent with coincidingin vivo2-para-(iodophenyl)-3(nitrophenyl)-5(phenyl) tetrazolium chloride respiratory stain measurements and historical site estimates. We estimate that 58% of gross primary production was respired at the Pacific site and 34% at the Atlantic site, demonstrating that the Atlantic had a higher carbon export potential. This study highlights the dynamic nature of respiration across vertical, temporal, and size-fractionated factors, emphasizing the need for sensitive, high-throughput techniques to better understand ocean ecosystem metabolism.
Lifelong learning measurement scale (LLMS): development and validation in the context of higher education institutions
Authors: Assefa Yalalem , Moges Bekalu Tadesse , Tilwani Shouket Ahmad 
Published: July 2023

PurposeLifelong learning has become one of the most interesting areas of research. Hence, the current study was aimed at developing and validating a tool that helps to study how well people working in higher education institutions are engaged in lifelong learning.Design/methodology/approachA review of theories in the literature and experts' consultation were used to develop a pool of items and validate the self-assessment instrument for measuring lifelong learning. The study employed factor analytic methodologies such as principal component analysis, varimax rotation and exploratory factor analyses.FindingsThe study yielded a reliable and valid lifelong learning measurement scale made up of 18 items and four underlying factors that are theoretically supported.Originality/valueThe significant information is that, the current study aimed at developing a tool that could help to measure the engagement in lifelong learning of higher education institutions workers. The study found this tool to be important because lifelong learning is considered essential for personal and professional growth, and having a sound way to measure it can help individuals and organizations identify areas for improvement.
Breaking new ground in family business research with neoconfigurational theorizing and analysis
Authors: Mallon Mark R. , Fainshmidt Stav 
Published: July 2023

PurposeBecause family businesses are highly complex enterprises, researchers need appropriate theoretical and methodological tools to study them. The neoconfigurational perspective and its accompanying method, qualitative comparative analysis, are particularly well suited to phenomena characterized by complex causality, but their uptake in family business research has been slow and fragmented. To remedy this, the authors highlight their unique ability to address research questions for which other approaches are not well suited and discuss how they might be applied to family business phenomena.Design/methodology/approachThe authors introduce the core tenets of the neoconfigurational perspective and how its set-theoretic epistemology differs from traditional approaches to theorizing and analysis. The authors then use a dataset of family firms to present a primer on conducting qualitative comparative analysis and interpreting the results.FindingsThe authors find that family firm resources can be combined in multiple ways to affect business survival, suggesting that resources are substitutable and complementary. The authors discuss how the unique features of the neoconfigurational approach, namely equifinality, conjunctural causation and causal asymmetry, can be fruitfully applied to break new ground in scholarly understanding of family businesses.Originality/valueThis article allows family business researchers to apply the neoconfigurational approach without first having to consult multiple and disparate sources often written for other disciplines. This article explicates how to leverage the theoretical and empirical advantages of the neoconfigurational approach in the context of family businesses, supporting a more widespread adoption of the neoconfigurational perspective in family business research.
Understanding project success involving analytic-based decision support in the digital era: a focus on IC and agile project management
Authors: Kudyba Stephan , D Cruz Agnel 
Published: July 2023

PurposeDigital transformations of business processes are on the rise and the result is a need for a better understanding of how the elements of intellectual capital (IC) play a role in achieving successful digital project outcomes. New structural capital in the form of digital technologies must be identified and understood. Evolving skills of human capital in assimilating digital elements must also be considered, while collaboration within the development process involving relational capital provides a critical integration among these IC elements. This study illustrates the importance of identifying and managing the integration of IC components within an agile project management framework that are essential to achieving success for a digital initiative. More specifically, this study describes the process by which a multinational technology-based products company successfully developed a dynamic decision support platform utilizing an agile approach to guide a project management team to better manage the company's operations.Design/methodology/approachThis study focuses on a case analysis approach of a multinational commercial and consumer products company. The paper presents existing research on the evolving state of project management for digital initiatives and focuses on agile methods. This study then delves into the case analysis that illustrates how IC played an integral role in the company successfully developing effective decision support involving an interactive dashboard using agile Project Management (PM), which enabled the project management team to better manage resources.FindingsAn examination at the case level illustrates that effective management and integration of IC has positive effects on project outcomes. While a balanced approach is evident as a requirement, the unique characteristics of the agile project management approach entails greater emphasis on select elements to adapt to a more dynamic development process.Originality/valueThis work depicts the complexities in providing analytic-based decision support in an agile/flexible project management scenario. This work adds to existing research by illustrating elements within IC categories and the elements' interdependencies that play an essential role in achieving success in this more flexible project environment.
Trading excess consumption certificates on the blockchain using the cooperative game theory
Authors: Ergün Serap 
Published: July 2023

PurposeThe purpose of this study is to propose a decentralized multi-party cross-trading scheme based on a certificate transaction mechanism for the transaction of excess consumption certificates (ECCs) of renewable energy. The aim is to address the problems associated with the existing centralized transaction mode and to promote the development of the green electricity industry.Design/methodology/approachThe proposed scheme involves calculating the quotation difference for the same type of certificate transaction based on the quotations of all users of both buyers and sellers. The transaction volume is then determined based on the order of quotation difference from large to small, and the total interests of cooperation are calculated. The nucleolus method is adopted to allocate the total interests to each member of the alliance and calculate the final transaction price. The blockchain technology is used for the transaction to achieve accurate traceability and efficient supervision, and a corresponding smart contract is designed and simulated in the Ethereum consortium chain.FindingsThe results of the simulation show the rationality and effectiveness of the proposed scheme. The decentralized multi-party cross-trading scheme can overcome the problems associated with the existing centralized transaction mode, such as low transaction efficiency, difficulty in obtaining the optimal transaction strategy and efficient supervision. The proposed scheme can promote the development of the green electricity industry by stimulating users' demand potential for green electricity.Originality/valueThe proposed scheme is original in its use of a certificate transaction mechanism to facilitate the trading of ECCs of renewable energy. The scheme adopts a decentralized multi-party cross-trading approach that overcomes the problems associated with the existing centralized transaction mode. The use of the nucleolus method for the allocation of total interests to each member of the alliance is also original. Finally, the use of blockchain technology for accurate traceability and efficient supervision of the transaction is an original contribution to the field.
Research on the social responsibility performance and its contributing factors to multinational corporations in China
Authors: Zhou Huating , Hou Yuwei , Wang Hong 
Published: July 2023

Purpose
The purpose of this paper is to explore the social responsibility performance’s current situation, influencing factors and mechanisms of multinational companies (MNCs) in China. The paper is based on the MNC’s social responsibility performance factors to find some relevant reasons for unsatisfied performance and on the multiple perspectives such as institutional distance and stakeholders, to provide feasible solutions for MNCs to assume civic responsibility and the high-quality development of the host country.

Design/methodology/approach
The study uses general literature review and empirical analysis to analyze the way and degree of various factors which are affecting the social responsibility of MNC in China, and supplements the deficiencies of previous studies.

Findings
The paper reveals the influencing factors and mechanisms of MNCs’ social responsibility in China through the regression results. In addition, based on Research Report on Corporate Social Responsibility of China (Huang et al., 2013/2019), the paper also summarizes the performance and dynamic changes of MNCs social responsibility in the Chinese market in the past decade.

Originality/value
The paper enriches research on the social responsibility of MNCs in the background of non-western countries, dynamically describes the performance of MNCs’ responsibilities in a 10-year span and solves the problem of inconsistent research conclusions caused by too long time span. The paper also creates the “local enterprise responsibility level” to quantify the development of the host country’s responsibility, and identifies the “responsibility demonstration effect” of state-owned enterprises and private enterprises.
Conceptualizing smart citizen: relationships and reciprocity with smart government
Authors: Younus Muhammad , Nurmandi Achmad , Suswanta Suswanta , Suardi Wahdania 
Published: July 2023

Purpose
The purpose of this paper is to focus on explaining the concept of a smart citizen and in what way it is related to and dependent on smart government.

Design/methodology/approach
To study this specific use case, researchers use “Qualitative Research.” For the review of the literature, the authors used an indirect citation. Additionally, VOSviewer software was used to evaluate the research data for this paper.

Findings
As researchers, the authors will explain how smart governments lay the foundation for transforming an ordinary citizen into a smart citizen. Also, they will be highlighting the significance and importance of citizens becoming smart in the future and how it will give an edge to any country over others in terms of development and growth.

Originality/value
After it, the authors will be sharing the essential qualities that are joined together to make a smart citizen and able to distinguish between a common citizen and smart citizen. Finally, creating an understanding of it, the emphasis will be on the facilities and services smart citizens will get under a smart government, which will eventually increase the smartness of the citizens.
l‐Arginine treatment maintains postharvest quality in blueberry fruit by enhancing antioxidant capacity during storage
Authors: Wang Jiaqi , Wang Yajuan , Li Yuxuan , Yang Ling , Sun Bingxin , Zhang Yunhe , Xu Yufeng , Yan Xuerui 
Published: July 2023

AbstractThe postharvest quality of blueberry fruit is largely limited by deterioration. l‐arginine (Arg) is a functional nontoxic amino acid with high biological activities. This study investigated the positive effects and the underlying mechanism of Arg treatment on the quality of postharvest blueberries. Arg effectively mitigated fruit decay and improved the quality of blueberries, including weight loss, firmness, and soluble solid content. Mechanistically, Arg‐mediated activation of the anti‐oxidative defense system reduced reactive oxygen species–mediated oxidative damage. Moreover, Arg treatment decreased the activities and gene expression of phospholipase D, lipoxygenase, and lipase‐inhibiting membrane lipid peroxidation during the prolonged storage of blueberries. Meanwhile, Arg treatment increased nitric oxide (NO) content and NO synthase activity. Furthermore, correlation and principal component analyses revealed the enhancement of Arg treatment on antioxidant capacity. This study suggests that Arg treatment can maintain the postharvest quality of blueberries by improving antioxidant capacity.