bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adverse outcomes of nonnuchal umbilical cord entanglement
Authors: Beer Noam , Danieli‐Gruber Shir , Bardin Ron , Berezowsky Alexandra , Hadar Eran , Arbib Nissim 
Published: July 2023

AbstractObjectiveTo evaluate perinatal effects of umbilical cord entanglement (UCE) of different body parts.MethodsThe database of a tertiary medical center was retrospectively searched for women who gave birth to a liveborn singleton newborn in 2014–2018. Those diagnosed postpartum with UCE were matched 1:10 with women who were not and compared for adverse obstetric and neonatal outcomes, overall and by site of entanglement.ResultsA total of 14 299 women were evaluated, of whom 1243 were diagnosed with UCE: 78.7% neck, 26% trunk, 6.7% limb. UCE was associated with lower birth weight percentile and higher rate of small for gestational age, but findings were significant only for neck and trunk UCE. On multivariate regression analysis adjusted for maternal age, parity, gestational age at birth, and history of cesarean delivery, UCE was an independent risk factor for nonreassuring fetal heart rate, labor induction, operative vaginal delivery, cesarean delivery, and meconium‐stained amniotic fluid, but not for lower absolute birth weight/birth weight percentile, small for gestational age, low 1‐min Apgar score, or neonatal asphyxia.ConclusionWhile fetuses with UCE might be more compromised during labor, they apparently recover shortly after birth. The impact on perinatal outcomes was similar for UCE of the neck and trunk and lower for UCE of the limb.
Intraoperative predictors of appendiceal abnormalities in patients with mucinous ovarian neoplasms
Authors: Lavecchia Melissa , Dubey Anisha , Jimenez Waldo , Reade Clare J. , Salehi Amir , Yang Ilun , Eiriksson Lua R. 
Published: July 2023

AbstractObjectiveTo evaluate intraoperative factors predicting appendiceal pathology during gynecologic oncology surgery for suspected mucinous ovarian neoplasms.MethodsWe conducted a retrospective study on 225 patients with mucinous ovarian neoplasms who underwent surgery for an adnexal mass with concurrent appendectomy between 2000 and 2018. Regression analyses were used to evaluate intraoperative factors, such as frozen section of the ovarian mass and surgeon's impression of the appendix in predicting appendiceal pathology.ResultsMost patients (77.8%) had a normal appendix on final pathology. Abnormal appendix cases (n = 26) included: metastasis from high‐grade adenocarcinoma of the ovary (n = 1), neuroendocrine tumor of the appendix (n = 4), and low‐grade appendiceal mucinous neoplasms (n = 26; 23 associated with a mucinous ovarian adenocarcinoma, 2 with a benign mucinous ovarian cystadenoma, and 1 with a borderline mucinous ovarian tumor). Combining normal intraoperative appearance of the appendix with benign or borderline frozen section yielded a negative predictive value of 85.1%, with 14.9% of patients being misclassified, and 6.0% having a neuroendocrine tumor or low‐grade appendiceal neoplasm.ConclusionBenign or borderline frozen section of an ovarian mucinous neoplasm and normal appearing appendix have limited predictive value for appendiceal pathology. Appendectomy with removal of the mesoappendix should be considered in all cases of mucinous ovarian neoplasm, regardless of intraoperative findings.
Circ_PRDM5/miR‐25‐3p/ANKRD46 axis is associated with cell malignant behaviors in subjects with breast cancer evaluated by ultrasound
Authors: Lu Qin , Sun Huihui , Yu Qian , Tang Dongdong 
Published: July 2023

AbstractCircular RNAs (circRNAs) are key RNA molecules in cancer biology. CircRNA PR/SET domain 5 (circ_PRDM5, hsa_circ_0005654) was downregulated in breast cancer (BC) tissues. This study is designed to investigate the functional mechanism of circ_PRDM5 in BC. Ultrasound examinations were performed to evaluate BC patients and normal individuals. Circ_PRDM5, miR‐25‐3p, and Ankyrin repeat domain 46 (ANKRD46) level detection was carried out by reverse transcription‐quantitative polymerase chain reaction. 3‐(4, 5‐dimethylthiazol‐2‐y1)‐2, 5‐diphenyl tetrazolium bromide (MTT) assay was used for cell viability examination. Cell proliferation was evaluated by ethynyl‐2′‐deoxyuridine assay and colony formation assay. The protein levels were examined using western blot. Cell migration and invasion abilities were assessed via transwell assay. Target interaction was analyzed via dual‐luciferase reporter assay. The role of circ_PRDM5 in vivo was explored via xenograft tumor assay. Circ_PRDM5 expression was downregulated in BC tissues and cells. Overexpression of circ_PRDM5 suppressed proliferation and motility but enhanced apoptosis of BC cells. Circ_PRDM5 served as a sponge of miR‐25‐3p. Circ_PRDM5 impeded BC cell malignant development via sponging miR‐25‐3p. Circ_PRDM5 induced ANKRD46 upregulation by targeting miR‐25‐3p. Inhibition of miR‐25‐3p retarded BC progression by increasing the ANKRD46 level. Circ_PRDM5 repressed BC tumorigenesis in vivo through mediating the miR‐25‐3p/ANKRD46 axis. This study evidenced that circ_PRDM5 inhibited cell progression and tumor growth in BC via interacting with mir‐25‐3p/ANKRD46 network.
Regulating excited‐state intramolecular proton transfer behavior and fluorescent property of 3‐thiolflavone by electron‐donating ability: A time‐dependent density functional theory study
Authors: Zhang Zhengyi , Fang Hua 
Published: July 2023

AbstractBackgroundSince the excited‐state intramolecular proton transfer (ESIPT) process involving sulfur is extremely fast, its mechanism is still unclear, and its derivatives are rarely studied, we have performed a theoretical study the ESIPT process of 3‐thiolflavone (3TF) and its derivatives.ObjectiveThe ESIPT mechanism and photophysicalproperties of 3‐thiolflavone (3TF) and its derivatives 3NTF, 3ATF and 3OTF modified by ‐N(C2H5)2, ‐NH2 and ‐OCH3 groups were studied theoretically.MethodsDensity functional theory (DFT) and time‐dependent density functional theory (TD‐DFT) with PBE0 functional and 6‐31G(d, p) basis set.ResultsFor 3TF, 3NTF, 3ATF and 3OTF, the ESIPT processes are barrier‐less, and the barrier of ground‐state intramolecular proton transfer (GSIPT) reduces in the order of 3TF > 3OTF > 3ATF > 3NTF, as the electron‐donating ability of the substituent increases. When the electron‐donating groups are introduced, the absorption and fluorescence wavelengths of 3TF red‐shift and blue‐shift, respectively.ConclusionSubstituents with electron‐donating ability can regulate the ground‐state intramolecular proton transfer process and photophysical properties of 3TF.
Preparation of Fe‐based magnetic‐core‐supported Co and Ni catalyst: application in viscosity reduction of heavy oil hydrocracking
Authors: Yan Shili , Zhu Jiamei , Wang Hongmin , Liu Bingqian , Bi Qinling 
Published: July 2023

AbstractBACKGROUNDHeavy oil has the characteristics of high viscosity and low American Petroleum Institute gravity, which makes it difficult to transport and produce. The key to efficiently utilizing heavy oil is reducing viscosity and improving quality. Hydroconversion has the advantages of viscosity reduction and decreased coke production, but it is difficult to separate nonmagnetic catalysts from the reaction system, which affects the industrial application.RESULTSA spherical Fe3O4 (74.71 emu g−1) and a chain FeFe2O3 (110 emu g−1) were prepared as magnetic cores, and coated with SiO2 and Al2O3 layers, respectively. The metal‐supported catalyst modified with Co and Ni show irregular and honeycomb‐shaped surfaces, and the magnetic saturation strength decreases to 24.91 and 14.63 emu g−1, but still possessing superparamagnetic properties, enabling the catalysts to be separated from the reaction mixture. Fe‐Fe2O3@SiO2@Al2O3@CoNi catalyst has the best viscosity reduction effect for Canadian oil sands asphalt residue at about 410 °C and 10 MPa hydrogen pressure. The viscosity of the liquid product decreased significantly from 56 600 to 135 mPa s at 50 °C, with a viscosity reduction of 99.8%.CONCLUSIONMagnetic catalyst prepared from chain‐like Fe‐Fe2O3 has an excellent honeycomb structure, which can provide increased active surfaces and exhibit improved viscosity reduction performance. This work provides a strategy for the recovery of heavy oil hydrogenation catalysts and is expected to play a key role in the practical application of heavy oil hydrogenation catalytic viscosity reduction. © 2023 Society of Chemical Industry.
Prior appendectomy and cerebral infarction as potential risk factors for recurrent ischemic colitis: A retrospective observational study
Authors: Takatsu Tomohiro , Misawa Noboru , Yoshihara Tsutomu , Ashikari Keiichi , Kessoku Takaomi , Ohkubo Hidenori , Hosono Kunihiro , Yoneda Masato , Saito Satoru , Nakajima Atsushi , Higurashi Takuma 
Published: July 2023

AbstractBackground and AimIschemic colitis (IC) is a benign disease associated with acute lower gastrointestinal bleeding and frequent recurrence. While several studies have investigated risk factors for IC onset, few have assessed the risk factors for recurrent IC. This study aimed to identify risk factors for recurrent IC.MethodsPotential risk factors for recurrence were assessed by examining medical records and laboratory findings in this single‐center retrospective study. We extracted the following data from the patients' medical records: patient characteristics, clinical signs and symptoms, laboratory findings, method of treatment, length of hospital stay, disease course, and the frequency of IC morbidities. Patients with IC were selected from a total of 439 312 patients over an 11‐year period. Patients were divided into recurrent and nonrecurrent IC groups.ResultsIn total, 225 patients met the diagnostic criteria for IC during the specified study period; of these, 204 patients (90.7%) and 21 patients (9.3%) were included in the nonrecurrent and recurrent IC groups, respectively. Univariate and multivariate analyses showed a significant association between IC recurrence and both cerebral infarction (P = 0.008, odds ratio [OR] = 6.3) and history of appendectomy (P = 0.0005, OR = 6.2). The median (interquartile range [IQR]) follow‐up time for all patients was 1556 (353–2768) days; this was much longer than the median (IQR) time to recurrence of 291 (64–907) days in the recurrent IC group.ConclusionThe results of this study suggest that prior cerebral infarction and appendicectomy may be risk factors for IC recurrence.
Off‐brand: A 6‐year study of medication brand and generic name usage in a multifacility academic healthcare system
Authors: Steinkamp Jackson , Hecht Todd E. H. , Hennessy Sean , Leonard Charles E. , Shu Di , Airan‐Javia Subha 
Published: July 2023

AbstractBackgroundUsage of medication brand names in electronic health records may introduce conflicts of interest, perpetuate false perceptions of brand superiority, alter prescribing practices, and cause confusion leading to errors.ObjectiveWe sought to identify the frequency of brand name medication usage in clinical documentation, as well as factors associated with increased usage.Designs, Settings, and ParticipantsWe conducted a retrospective analysis of all clinical documentation written at our healthcare system (a multifacility academic urban healthcare system) between 2015 and 2020.Main Outcomes and MeasuresWe used string‐matching and regular expressions to identify medication mentions. We conducted bivariate analyses to identify associations between brand name usage and author‐, note‐, and medication‐level factors, and a multivariate Poisson regression to clarify independent associations between individual factors and brand usage.ResultsA total of 104,456,653 notes from 37,285 unique authors were included in our analysis. A total of 162,906,009 medication mentions were identified, of which 36.0% were brand name mentions with a steady year‐over‐year decrease. Factors associated with the usage of a brand name include: author role, years since release, length and syllabic complexity of the generic name, service type, and encounter context. Over‐the‐counter availability did not affect usage. There was sizable individual variation between note writers.
Outpatient atorvastatin use and severe COVID‐19 outcomes: A population‐based study
Authors: Visos‐Varela Irene , Zapata‐Cachafeiro Maruxa , Pintos‐Rodríguez Samuel , Bugarín‐González Rosendo , González‐Barcala Francisco Javier , Herdeiro Maria T. , Piñeiro‐Lamas María , Figueiras Adolfo , Salgado‐Barreira Ángel 
Published: July 2023

AbstractEvidence of the effect of statins on patients with coronavirus disease (2019) COVID‐19 is inconsistent. The aim of this study was to evaluate the association between chronic use of statins—both overall and by active ingredient—and severe outcomes of COVID‐19 (risk of hospitalization and mortality), progression to severe outcomes, and susceptibility to the virus. We conducted a population‐based case–control study with data from electronic records to assess the risk of (1) hospitalization: cases were patients admitted due to COVID‐19 and controls were subjects without COVID‐19; (2) mortality: cases were hospitalized patients who died due to COVID‐19 and controls were subjects without COVID‐19; (3) progression: cases were hospitalized COVID‐19 subjects and controls were nonhospitalized COVID‐19 patients; and (4) susceptibility: cases were patients with COVID‐19 (both hospitalized and nonhospitalized) and controls were subjects without COVID‐19. We collected data on 2821 hospitalized cases, 26 996 nonhospitalized cases, and 52 318 controls. Chronic use of atorvastatin was associated with a decreased risk of hospitalization (adjusted odds ratios [aOR] = 0.83; 95% confidence interval [CI]: 0.74–0.92) and mortality (aOR = 0.70; 95% CI: 0.53–0.93), attributable in part to a lower risk of susceptibility to the virus (aOR = 0.91; 95% CI: 0.86–0.96). Simvastatin was associated with a reduced risk of mortality (aOR = 0.59; 95% CI: 0.40–0.87). The wide degree of heterogeneity observed in the estimated odds ratios (ORs) of the different statins suggests that there is no class effect. The results of this real‐world study suggest that chronic use of atorvastatin (and to a lesser degree, of simvastatin) is associated with a decrease in risk of severe COVID‐19 outcomes.
Associations between DSM‐5 posttraumatic stress disorder Criterion E2 endorsement and selected self‐destructive behaviors in recent‐era veterans: A focus on disordered eating
Authors: Zelkowitz Rachel L. , Kehle‐Forbes Shannon M. , Smith Brian N. , Vogt Dawne S. , Mitchell Karen S. 
Published: July 2023

AbstractRevisions to the posttraumatic stress disorder (PTSD) criteria in the DSM‐5 included a new criterion in the alterations in arousal and reactivity cluster (i.e., engagement in reckless and self‐destructive behaviors; Criterion E2). Despite its clinical significance, little is known about how this symptom corresponds to engagement in specific direct and indirect self‐harm behaviors. We examined associations between E2 and self‐reported recent engagement in direct and indirect self‐harm behaviors, including disordered eating, which is not included in the prototypical E2 symptom scope, in a trauma‐exposed sample of 1,010 recent‐era veterans (61.5% self‐identified women, 38.5% self‐identified men). We also tested whether gender moderated these associations. We repeated analyses in a subsample of participants with clinically elevated PTSD symptoms. Participants self‐reported past‐month PTSD symptoms (PCL‐5) as well as past‐month nonsuicidal self‐injury, suicidal ideation, suicide planning, fasting, purging, binge eating, compulsive exercise, and problematic alcohol and drug use. We found no evidence for moderation by gender for any of the behaviors examined in the main sample. However, after controlling for gender and demographic covariates, weighted logistic regressions showed small, significant associations between E2 score and direct self‐harm behaviors, substance use, purging, and binge eating, aORs = 1.30–1.91. Criterion E2 was linked to behaviors included in the typical symptom scope (self‐directed violence, substance use) and those that are not (disordered eating behaviors). Comprehensive screening for self‐destructive behaviors, including disordered eating, among veteran men and women who endorse Criterion E2 is indicated.
Diagnostic Value of Contrast‐Enhanced Ultrasonography for Catheter‐Related Right Brachiocephalic Vein and Superior Vena Cava Lesions in Patients Undergoing Hemodialysis—A Pilot Study
Authors: Fen Yu , Yin Wang , Li‐ming Gan , Hui‐ling Fu , Wei Xiao , Jian‐xin Liu , Xiao‐mei Huang 
Published: July 2023

ObjectivesTo evaluate the diagnostic efficacy of contrast‐enhanced ultrasonography (CEUS) for detecting catheter‐related right brachiocephalic vein (RBV) and superior vena cava (SVC) obstructions in patients undergoing hemodialysis (HD).MethodsFrom June 1, 2021 to December 31, 2022, we enrolled 80 patients undergoing HD who had used or were using a central venous catheter as vascular access. We evaluated the diagnostic efficacy of conventional ultrasonography and CEUS for identifying RBV and SVC obstructions and compared them with that of digital subtraction angiography (DSA). In the stratified analysis, the SVC was divided into the upper and lower segments. In total, we analyzed 240 central venous segments, including the RBV.ResultsAmong the RBV and SVC visualized by DSA, conventional ultrasonography and CEUS could visualize 67.92 and 100% of the vein segments, respectively; however, the lengths and diameters of the RBV and SVC were smaller than those recorded with DSA (P < .001). The diagnostic efficacy of CEUS for detecting catheter‐related central venous obstruction was better than that of conventional ultrasonography, with a higher sensitivity (83.95 vs 41.98%), specificity (89.94 vs 53.46%), accuracy (87.92 vs 49.58%), and F1 score (82.42 vs 49.64%). CEUS showed good agreement (κ = 0.732) with DSA. In the stratified analyses, CEUS also showed higher sensitivity (83.93, 83.33, and 84.62%, respectively) and better agreement with DSA (κ = 0.635, 0.655, and 0.673, respectively) than conventional ultrasonography for detecting the RBV and the upper and lower segments of the SVC.ConclusionsCEUS had high sensitivity and specificity in diagnosing catheter‐related RBV and SVC obstructions.
Laryngeal symptoms related to motor phenotypes in Parkinson's disease: A systematic review
Authors: Thijs Zoe , Dumican Matthew 
Published: July 2023

AbstractObjectiveThis study aimed to systematically review the associations between motor clinical phenotypes in Parkinson's disease (PD) and laryngeal disease symptoms. Laryngeal dysfunctions such as dysphonia and dysphagia are ubiquitous in people with Parkinson's disease (PwPD). Similar to other disease symptoms, they manifest variably across PwPD. Some of the variability within PD has been explained by clinical phenotypes. However, it is unclear how laryngeal symptoms of PD express themselves across these phenotypes.MethodsFive databases were searched (MEDLINE, CINAHL, Web of Science, Embase, Scopus) in May 2022. After the removal of duplicates, all retrieved records were screened. Cohort, case–control, and cross‐sectional studies in English discussing laryngeal symptoms and clinical PD phenotypes were included. Data were extracted, tabulated, and assessed using Moola et al.'s (2021) appraisal tool for systematic reviews of risk and etiology.ResultsThe search retrieved 2370 records, representing 540 PwPD. After the removal of duplicates and screening, eight articles were included for review. The most common phenotype categories were tremor‐dominant and postural‐instability gait disordered (PIGD). Five studies addressed vocal characteristics, while four considered swallowing. Differences and lack of rigor in methodology across studies complicated conclusions, but a tendency for tremor‐dominant phenotypes to present with less severe laryngeal symptoms was found.ConclusionSome minor differences in laryngeal function were found between tremor‐dominant and PIGD phenotypes in PD. However, there is a need for more standardized and high‐quality studies when comparing motor phenotypes for laryngeal function.
Association of serum brain‐derived neurotrophic factor level and early response to antipsychotic drug in first‐episode patients with schizophrenia
Authors: Zhao Tong , Tang SuFang , Gao XiaoLei , Li Juan , Hao Ran , Chen HaiZhi , Huang GuangBiao 
Published: July 2023

AbstractObjectivesTo investigate the role of Brain derived neurotrophic factor (BDNF) in the psychotic symptoms in first‐episode patients with schizophrenia and whether BDNF levels were associated with the improvement of psychotic symptoms after risperidone treatment.Methods89 schizophrenia patients and 90 healthy controls were recruited, the schizophrenia patients were assigned into early response or early non‐response groups at 2 weeks based on improvement in the positive and negative symptoms scale (PANSS) total score. All patients were treated with risperidone for 2 weeks, their serum BDNF levels were compared at baseline and after 2 weeks treatment.ResultsWe found that patients had lower BDNF levels, compared to controls at baseline. After 2 weeks of treatment of risperidone, BDNF levels were significantly increased and psychotic symptoms were decreased in early response group. Correlation analysis showed that the change of BDNF levels after treatment was correlated with the change of PANSS total score. Further regression analysis showed that the change in BDNF levels was an independent predictor for the improvement in psychotic symptoms.ConclusionsOur findings reveal that the level of BDNF was lower in first‐episode schizophrenic patients, moreover, the changes in serum BDNF levels may have a predictive effect on the early improvement in psychotic symptoms in the first 2 weeks.
The expression levels of NOS2, HMOX1, and VEGFC in cumulus cells are markers of oocyte maturation and fertilization rate
Authors: Barragán Montserrat , Cornet‐Bartolomé David , Molina Natalia , Vassena Rita 
Published: July 2023

AbstractThroughout the reproductive life of women, cumulus cells (CC) protect the dormant oocyte from damage, act as sensors of the follicular microenvironment, and act as a gatekeeper for oocyte developmental potential. One such mechanism relies on the hypoxia‐tolerance response, which, with age, decreases systematically, including in the ovary. We aimed to evaluate the association between gene expression related to hypoxia and aging in CC and reproductive results in in vitro fertilization cycles. We recruited 94 women undergoing controlled ovarian stimulation. Total RNA was extracted from pooled CCs collected after oocyte pick‐up (OPU) and reverse‐transcribed to complementary DNA using random hexamers to test 14 genes related to hypoxia response via HIF1α activation, oxidative stress, and angiogenic responses. The expression of CLU, NOS2, and TXNIP had a positive correlation with age (rs = 0.25, rs = 0.24, and rs = 0.35, respectively). Additionally, NOS2 and HMOX1 expression correlated positively with the retrieval of immature oocytes (rs = 0.22 and rs = 0.40, respectively). Moreover, VEGFC levels decreased overall with increasing fertilization rate, independently of age (rs = −0.29). We found that the fertilization potential of a cohort of oocytes is related to the ability of CC to respond to oxidative stress and hypoxia with age, pointing at NOS2, HMOX1, and VEGFC expression as markers for oocyte maturation and fertilization success.