bluuebunny/crossref_metadata_2025_split huggingface dataset:
Urban Firefighting Drones: Precise Throwing from UAV
Authors: Perez-Saura David , Fernandez-Cortizas Miguel , Perez-Segui Rafael , Arias-Perez Pedro , Campoy Pascual 
Published: July 2023

AbstractIn recent years, the use of unmanned aerial vehicles has spread across different fields of the industry due to their ease of deployment and minimal operational risk. Firefighting is a dangerous task for the humans involved, in which the use of UAVs presents itself as a good first-action protocol for a rapid response to an incipient fire because of their safety and speed of action. Current research is mainly focused on wildland fires, but fires in urban environments are barely mentioned in the bibliography. To motivate the research on this topic, ICUAS’22 organized an international competition inspired by this mission, with the challenge of a UAV traversing an area populated by obstacles, finding a target, and precisely throwing a ball to it. For this competition, the Computer Vision and Aerial Robotics (CVAR-UPM) team developed a solution composed of multiple modules and structured by a mission planner. In this paper, we describe our approach and the developed architecture that led us to be awarded the first prize in the competition.
Naringin and naringenin counteract taxol-induced liver injury in Wistar rats via suppression of oxidative stress, apoptosis and inflammation
Authors: Khaled Shimaa S. , Soliman Hanan A. , Abdel-Gabbar Mohammed , Ahmed Noha A. , El-Nahass El-Shaymaa , Ahmed Osama M. 
Published: July 2023

AbstractThis research aimed to evaluate the preventing effects of naringin, naringenin, and their combination on liver injury induced by Taxol (paclitaxel) in Wistar rats. Male Wistar rats received 2 mg/kg Taxol intraperitoneal injections twice weekly on the second and fifth days of each week for 6 weeks. During the same period as Taxol administration, rats were given naringin, naringenin, or a combination of the two (10 mg/kg b.wt) every other day. Treatment with naringin and/or naringenin reduced the abnormally high serum levels of total bilirubin, aspartate transaminase, alanine transaminase, alkaline phosphatase, lactate dehydrogenase, and gamma-glutamyl transferase in Taxol-treated rats. It also significantly increased the level of serum albumin, indicating an improvement in the liver. The perturbed histological liver changes were markedly improved due to the naringin and/or naringenin treatment in Taxol-administered rats. Additionally, the treatments reduced high hepatic lipid peroxidation and increased liver glutathione content as well as the activities of superoxide dismutase and glutathione peroxidase. Furthermore, the treatments reduced the levels of alpha-fetoprotein and caspase-3, a pro-apoptotic mediator. The naringin and naringenin mixture appeared more effective in improving organ function and structural integrity. In conclusion, naringin and naringenin are suggested to employ their hepatoprotective benefits via boosting the body’s antioxidant defense system, reducing inflammation, and suppressing apoptosis.Graphical Abstract
Brain–Computer Interfaces, Completely Locked-In State in Neurodegenerative Diseases, and End-of-Life Decisions
Authors: Poppe Christopher , Elger Bernice S. 
Published: July 2023

AbstractIn the future, policies surrounding end-of-life decisions will be faced with the question of whether competent people in a completely locked-in state should be enabled to make end-of-life decisions via brain-computer interfaces (BCI). This article raises ethical issues with acting through BCIs in the context of these decisions, specifically self-administration requirements within assisted suicide policies. We argue that enabling patients to end their life even once they have entered completely locked-in state might, paradoxically, prolong and uphold their quality of life.
Habitat heterogeneity enhances megafaunal biodiversity at bathymetric elevations in the Clarion Clipperton Fracture Zone
Authors: Uhlenkott Katja , Simon-Lledó Erik , Vink Annemiek , Martínez Arbizu Pedro 
Published: July 2023

AbstractThe Clarion Clipperton Fracture Zone (CCZ) in the northeast Pacific is a heterogeneous deep-sea environment, featuring abyssal plains as well as multiple seamounts and abyssal hills (bathymetric elevations) that harbour a highly diverse megabenthic fauna. Based on the analysis of seafloor photographic transects that were taken from elevated areas downslope into the abyssal plains in the eastern CCZ, a similar distribution of habitats was observed on five different bathymetric elevations including abyssal hills as well as the foothills of two seamounts. Rock outcrops occur at the summits, surrounded by an area with varying coverage and size of polymetallic nodules, which were divided into two different habitats characterized by large and small nodules, respectively, and followed by nodule-free sediments. Megafauna composition, density and diversity varies across these habitats. While density is the highest in areas with rock outcrops (1.4 individuals per m2), the biodiversity is the highest when regarding all of the habitats combined. Regarded individually, nodule-covered areas are the most diverse, whereas sediment areas without hard substratum, i.e. nodule free sediments, show the lowest biodiversity and the lowest density (0.2 individuals per m2). The multinomial species classification method (CLAM) shows that most of the observed megafauna morphotypes have to be regarded as rare. The large differences between the megafaunal communities at bathymetric elevations and the abyssal plain reported from previous studies might partly be explained by the multiplicity of habitats. This high heterogeneity can lead to a more diversified community at elevations, although most habitats can also be observed in the abyssal plain.
Regioselective three-component synthesis and theoretical calculations of new alkane-linked bis(thiazol-2(3H)-imine) hybrids: a DFT-based FMO and local reactivity indices
Authors: Ahmed Mohamed S. Mohamed , Mekky Ahmed E. M. , Sanad Sherif M. H. 
Published: July 2023

AbstractA three-component approach was conducted to adeptly prepare a new series of (Z)-bis(N-phenylthiazol-2(3H)-imines. The newly synthesized compounds were prepared by refluxing a ternary mixture of phenyl isothiocyanate, the suitable α-bromoketones, and alkane-linked diamines in ethanol. Reaction conditions were optimized by comparing the yield of the final product under various bases, solvents, temperatures, and base-to-starting-materials molar ratios. The intended hybrids were produced with 85–96% yields while using ethanol at 80 °C for 3–5 h in the presence of anhydrous sodium acetate. The ascribed configuration of new products as well as the regioselectivity of the one-pot reaction were confirmed using both spectral data (1D and 2D NMR) and DFT-calculation techniques.
Graphical abstract
Vegetation dynamics and its driving factors in agro-climatic zones of Upper Bhima Sub-basin, Western India
Authors: Londhe D. S. , Katpatal Y. B. , Mukesh M. S. , Bokde N. D. 
Published: July 2023

AbstractClimate change is a key threat to biodiversity and ecosystems. The impacts of climate change on vegetation must be evaluated to control the sustainability of the ecosystem. Precipitation and temperature are the most important climatic parameters affecting vegetation growth. It is important to analyze the spatial and temporal variations of vegetation under changing climatic parameters to envisage the response to the regional ecosystem. In this study, variation of the Normalized Difference Vegetation Index over five different agro-climatic zones in the Upper Bhima Sub-basin from 2003 to 2013 was analyzed to find the effect of climatic and hydrological variables on vegetation dynamics. The correlation analysis has been performed by using the Pearson correlation method and Geographical Detector Model. Taylor diagrams are generated to highlight the variation in the correlation values of NDVI with other variables. Results show that precipitation and temperature are key parameters for the growth of the vegetation, but Western Ghat Zone shows contradictory results. To identify the reasons behind contradictory results in the Western Ghat Zone, hydrological parameters such as soil moisture, terrestrial water storage and groundwater levels are analyzed. NDVI shows a positive correlation with precipitation in Water Scarcity Zone, and Assured Rainfall Zone with correlation values 0.37, and 0.462 respectively, but, in the Western Ghat Zone, NDVI has a negative correlation (− 0.38) though more than average precipitation occurs in that region. The result of the Geographical Detector Model reveals that the terrestrial water storage and precipitation are dominant factors affecting vegetation in WGZ and WSZ, respectively.
Exploring the variability of sarcopenia prevalence in a research population using different disease definitions
Authors: Cegielski Jessica , Bass Joseph J. , Willott Ruth , Gordon Adam L. , Wilkinson Daniel J. , Smith Ken , Atherton Philip J. , Phillips Bethan E. 
Published: July 2023

Abstract
Background
Sarcopenia is the progressive loss of muscle mass and function with age. A number of different sarcopenia definitions have been proposed and utilised in research. This study aimed to investigate how the prevalence of sarcopenia in a research cohort of older adults is influenced by the use of independent aspects of these different definitions.

Methods
Data from 255 research participants were compiled. Defining criteria by the European Working Group on Sarcopenia in Older People, the International Working Group on Sarcopenia (IWGS), and the Foundation for the National Institutes of Health were applied.

Results
Prevalence of sarcopenia using muscle mass ranged from 4 to 22%. Gait speed and handgrip strength criteria identified 4–34% and 4–16% of participants as sarcopenic, respectively.

Conclusion
Prevalence of sarcopenia differs substantially depending on the criteria used. Work is required to address the impact of this for sarcopenia research to be usefully translated to inform on clinical practice.
Intelligenza artificiale nella diagnostica del nodulo tiroideo
Authors: Barp Samuele , Grani Giorgio 
Published: July 2023

SommarioLa diagnostica del nodulo tiroideo si basa su ecografia ed esame citologico, gravati da variabilità interosservatore, malgrado l’adozione di sistemi classificativi. Sistemi di supporto alla diagnosi basati su intelligenza artificiale possono migliorare concordanza e performance diagnostica. Tali software, alcuni in commercio, possiedono una resa diagnostica sovrapponibile a quella degli esperti (il cui giudizio non risulta migliorato) e possono essere un supporto per i clinici meno esperti e durante la formazione.
How intelligent automation, service robots, and AI will reshape service products and their delivery
Authors: Wirtz Jochen , Pitardi Valentina 
Published: July 2023

AbstractIntelligent Automation in form of robots, smart self-service technologies, wearable technologies, software and systems such as machine learning, generative artificial intelligence (AI) such as ChatGPT, and the metaverse are increasingly adopted in a wide range of customer-facing service settings. The shift toward robot- and AI-powered services will lead to improved customer experiences, service quality, and productivity all at the same time. However, these also carry ethical, fairness, and privacy risks for customers and society. In this opinion piece, we discuss the implications of the service revolution for service firms, their marketing, and their customers, and provide avenues for future research opportunities.
Wenn der Magen „nicht mehr richtig schafft“
Authors: Bravo Francisco , Lenglinger Johannes , Borbely Yves , Wiest Reiner 
Published: July 2023

ZusammenfassungVerzögerte Magenentleerung ohne nachweisbare Obstruktion oder Ulzeration verbunden mit typischen Leitsymptomen – so lautet die Definition der Gastroparese. Als Leitsymptome gelten Übelkeit und Erbrechen. Zudem sind häufig ein frühes Sättigungs- und Völlegefühl, Blähungen und Oberbauchschmerzen assoziiert. Am häufigsten ist die idiopathische Gastroparese, gefolgt von der diabetischen und postoperativen Form. In dieser Übersicht wollen wir zunächst einen Überblick zur Epidemiologie, Pathophysiologie sowie den Ursachen und Risikofaktoren der Gastroparese geben. Ferner soll eine praxisnahe Zusammenfassung der konservativen Therapiemassnahmen (Ernährungsempfehlungen und pharmakologisches Armentarium), aber auch der zunehmend zum Einsatz kommenden interventionellen Verfahren gegeben werden. Schliesslich präsentieren wir einen Behandlungsalgorithmus als möglichen Therapiepfad für dieses komplexe Krankheitsbild.
Responsible artificial intelligence in human resources management: a review of the empirical literature
Authors: Bujold Antoine , Roberge-Maltais Isabelle , Parent-Rocheleau Xavier , Boasen Jared , Sénécal Sylvain , Léger Pierre-Majorique 
Published: July 2023

Abstract
As it is the case for many business processes and activities disciplines, artificial intelligence (AI) is increasingly integrated in human resources management (HRM). While AI has great potential to augment the HRM activities in organizations, automating the management of humans is not without risks and limitations. The identification of these risks is fundamental to promote responsible use of AI in HRM. We thus conducted a review of the empirical academic literature across disciplines on the affordances and responsible principles of AI in HRM. This is the first review of responsible AI in HRM that focuses solely on studies containing observations, measurements, and tests about this phenomenon. The multi-domain and multidisciplinary approach and empirical focus provides a better understanding of the reality of the development, study, and deployment of AI in HRM and sheds light on how these are conducted responsibly. We conclude with a call for research based on what we identified as the most needed and promising avenues.
The functions of natural theology in Thomas Aquinas: A presumption of atheism?
Authors: Huneeus Clemente 
Published: July 2023

AbstractAntony Flew argued for a ‘presumption of atheism’ that intended to put the philosophical debate about God under a light which demands setting the meaningfulness and logical coherence of the theistic notion of ‘God’ before any arguments for His existence are suggested. This way of proceeding, discussing divine attributes before considering the arguments for the existence of God, became dominant in analytic philosophy of religion. Flew also stated that Aquinas presented his five ways as an attempt to defeat such a presumption of atheism. However, Aquinas proceeds in the reverse order, beginning with God's existence before discussing the divine attributes. He does so because he believes that natural knowledge of God must be drawn from creatures. Accordingly, from the Thomist perspective, natural theology is necessary not because it provides rational justification for religious belief in God's existence, but rather as a means to fix the referent for the word ‘God’ (semantic function) and provide an intelligible account of the divine nature (hermeneutic function). We should also acknowledge a correlative hermeneutic function of religious faith. Therefore, natural theology should not begin from a presumption of atheism nor proceed in the way suggested by Flew, because its main intention is not strictly apologetical.
Cancer cell employs a microenvironmental neural signal trans-activating nucleus-mitochondria coordination to acquire stemness
Authors: He Bin , Gao Rui , Lv Shasha , Chen Ailin , Huang Junxiu , Wang Luoxuan , Feng Yunxiu , Feng Jiesi , Liu Bing , Lei Jie , Deng Bing , He Bin , Cui Bai , Peng Fei , Yan Min , Wang Zifeng , Lam Eric W-F , Jin Bilian , Shao Zhiming , Li Yulong , Jiao Jianwei , Wang Xi , Liu Quentin 
Published: July 2023

AbstractCancer cell receives extracellular signal inputs to obtain a stem-like status, yet how tumor microenvironmental (TME) neural signals steer cancer stemness to establish the hierarchical tumor architectures remains elusive. Here, a pan-cancer transcriptomic screening for 10852 samples of 33 TCGA cancer types reveals that cAMP-responsive element (CRE) transcription factors are convergent activators for cancer stemness. Deconvolution of transcriptomic profiles, specification of neural markers and illustration of norepinephrine dynamics uncover a bond between TME neural signals and cancer-cell CRE activity. Specifically, neural signal norepinephrine potentiates the stemness of proximal cancer cells by activating cAMP-CRE axis, where ATF1 serves as a conserved hub. Upon activation by norepinephrine, ATF1 potentiates cancer stemness by coordinated trans-activation of both nuclear pluripotency factors MYC/NANOG and mitochondrial biogenesis regulators NRF1/TFAM, thereby orchestrating nuclear reprograming and mitochondrial rejuvenating. Accordingly, single-cell transcriptomes confirm the coordinated activation of nuclear pluripotency with mitochondrial biogenesis in cancer stem-like cells. These findings elucidate that cancer cell acquires stemness via a norepinephrine-ATF1 driven nucleus-mitochondria collaborated program, suggesting a spatialized stemness acquisition by hijacking microenvironmental neural signals.
Purkinje cell microzones mediate distinct kinematics of a single movement
Authors: Blot François G. C. , White Joshua J. , van Hattem Amy , Scotti Licia , Balaji Vaishnavi , Adolfs Youri , Pasterkamp R. Jeroen , De Zeeuw Chris I. , Schonewille Martijn 
Published: July 2023

AbstractThe classification of neuronal subpopulations has significantly advanced, yet its relevance for behavior remains unclear. The highly organized flocculus of the cerebellum, known to fine-tune multi-axial eye movements, is an ideal substrate for the study of potential functions of neuronal subpopulations. Here, we demonstrate that its recently identified subpopulations of 9+ and 9- Purkinje cells exhibit an intermediate Aldolase C expression and electrophysiological profile, providing evidence for a graded continuum of intrinsic properties among PC subpopulations. By identifying and utilizing two Cre-lines that genetically target these floccular domains, we show with high spatial specificity that these subpopulations of Purkinje cells participate in separate micromodules with topographically organized connections. Finally, optogenetic excitation of the respective subpopulations results in movements around the same axis in space, yet with distinct kinematic profiles. These results indicate that Purkinje cell subpopulations integrate in discrete circuits and mediate particular parameters of single movements.
Measuring climate change’s impact on different sugarcane varieties production in the South of Goiás
Authors: Da Cruz Thiago Vizine , Machado Ricardo Luiz 
Published: July 2023

AbstractA crucial aspect analysed during the last years, aiming to improve sugarcane production, is the impact of climate change on sugarcane productivity. One of the strategies to mitigate climate change's impact on sugarcane yield is the development of new varieties known to positively affect crop production. This paper analysed how climate change impacts sugarcane production regarding the different planted varieties. Data regarding sugarcane harvest were collected from a cooperative in the south of Goiás state—Brazil, the second biggest national sugarcane producer. Results indicate that climate impact on sugarcane yield is irrelevant when controlling for different varieties. Considering the results presented in this work, the Brazilian government should keep the incentives for the development of new sugarcane varieties and, at the same time, spur sugarcane producers to use the new sugarcane varieties. The results imply that if the variety is correctly chosen, sugarcane can be produced without harming the environment, contributing to reaching SDG 15. Moreover, it is less probable that an adverse climatic event will destroy the planted area, preventing sugarcane producers from severe loss and contributing to achieving SDGs number 1 and 2.
A framework for comparative study of databases and computational methods for arrhythmia detection from single-lead ECG
Authors: Merdjanovska Elena , Rashkovska Aleksandra 
Published: July 2023

AbstractArrhythmia detection from ECG is an important area of computational ECG analysis. However, although a large number of public ECG recordings are available, most research uses only few datasets, making it difficult to estimate the generalizability of the plethora of ECG classification methods. Furthermore, there is a large variability in the evaluation procedures, as well as lack of insight into whether they could successfully perform in a real-world setup. To address these problems, we propose an open-source, flexible and configurable ECG classification codebase—ECGDL, as one of the first efforts that includes 9 arrhythmia datasets, covering a large number of both morphological and rhythmic arrhythmias, as well as 4 deep neural networks, 4 segmentation techniques and 4 evaluation schemes. We perform a comparative analysis along these framework components to provide a comprehensive perspective into arrhythmia classification, focusing on single-lead ECG as the most recent trend in wireless ECG monitoring. ECGDL unifies the class information representation in datasets by creating a label dictionary. Furthermore, it includes a set of the best-performing deep learning approaches with varying signal segmentation techniques and network architectures. A novel evaluation scheme, inter-patient cross-validation, has also been proposed to perform fair evaluation and comparison of results.
Anti-nanodisc antibodies specifically capture nanodiscs and facilitate molecular interaction kinetics studies for membrane protein
Authors: Nakagawa Fuhito , Kikkawa Marin , Chen Sisi , Miyashita Yasuomi , Hamaguchi-Suzuki Norie , Shibuya Minami , Yamashita Soichi , Nagase Lisa , Yasuda Satoshi , Shiroishi Mitsunori , Senda Toshiya , Ito Keisuke , Murata Takeshi , Ogasawara Satoshi 
Published: July 2023

AbstractNanodisc technology has dramatically advanced the analysis of molecular interactions for membrane proteins. A nanodisc is designed as a vehicle for membrane proteins that provide a native-like phospholipid environment and better thermostability in a detergent-free buffer. This enables the determination of the thermodynamic and kinetic parameters of small molecule binding by surface plasmon resonance. In this study, we generated a nanodisc specific anti-MSP (membrane scaffold protein) monoclonal antibody biND5 for molecular interaction analysis of nanodiscs. The antibody, biND5 bound to various types of nanodiscs with sub-nanomolar to nanomolar affinity. Epitope mapping analysis revealed specific recognition of 8 amino acid residues in the exposed helix-4 structure of MSP. Further, we performed kinetics binding analysis between adenosine A2a receptor reconstituted nanodiscs and small molecule antagonist ZM241385 using biND5 immobilized sensor chips. These results show that biND5 facilitates the molecular interaction kinetics analysis of membrane proteins substituted in nanodiscs.