bluuebunny/crossref_metadata_2025_split huggingface dataset:
Okra-psyllium based green synthesis of eco-friendly bio-adsorbent for efficient removal of uranium and crystal violet dye from aqueous media: statistical optimization using response surface methodology
Authors: Singh Anjali , Kaith Balbir Singh , Mehra Rohit , Balram  , Sardul Vikas , Bhatti Manpreet Singh 
Published: August 2023

Abstract
The prime objective of this study is to synthesize eco-friendly okra-psyllium based hydrogel through free radical crosslinking method by using citric acid-ammonium persulfate as a crosslinker-initiator system. Various techniques were used to explore the morphology, structure and thermal behaviour of the synthesized hydrogel via. Powdered X-ray diffraction studies, SEM and TGA techniques. Response surface methodology was performed to maximize the grafting percentage of the synthesized hydrogel up to 244 % and swelling percentage of 598 %. The physicochemical properties like salt-resistance behaviour and the impact of ionic strength on the swelling percentage of synthesized hydrogel were investigated and thus observed with the following trend as K+ > Ca2+ > Fe3+. Furthermore, the synthesized sample showed an excellent bio-adsorbent behaviour for the removal of uranium with 97.75 % removal in 60 min and crystal violet dye removal up to 85.32 % in 24 h from contaminated water. Various kinetic and isotherm adsorption modelling were implied to probe the mechanism of adsorption with displayed interactions between the absorbate and the absorbent. The Langmuir isotherm model was well-fitted in dye adsorption case with regression co-efficient value of 0.99. In case of uranium, tempkin isotherm model was best fitted with regression co-efficient value as 0.92. Crystal violet dye adsorption favoured second-order kinetic model whereas the adsorption mechanism of uranium followed first-order kinetics. Hence, the revealed results depicted that the synthesized hydrogel served as a potential candidate for the effective removal of toxic dye (crystal violet) and metal ion (uranium) from aqueous media with a sustainable approach towards environment.
Domain-Specific Cognitive Impairment Reflects Prefrontal Dysfunction in Aged Common Marmosets
Authors: Vanderlip Casey R. , Asch Payton A. , Reynolds John H. , Glavis-Bloom Courtney 
Published: August 2023

AbstractAge-related cognitive impairment is not expressed uniformly across cognitive domains. Cognitive functions that rely on brain areas that undergo substantial neuroanatomical changes with age often show age-related impairment, whereas those that rely on brain areas with minimal age-related change typically do not. The common marmoset has grown in popularity as a model for neuroscience research, but robust cognitive phenotyping, particularly as a function of age and across multiple cognitive domains, is lacking. This presents a major limitation for the development and evaluation of the marmoset as a model of cognitive aging and leaves open the question of whether they exhibit age-related cognitive impairment that is restricted to some cognitive domains, as in humans. In this study, we characterized stimulus–reward association learning and cognitive flexibility in young adults to geriatric marmosets using a Simple Discrimination task and a Serial Reversal task, respectively. We found that aged marmosets show transient impairment in learning-to-learn but have conserved ability to form stimulus–reward associations. Furthermore, aged marmosets have impaired cognitive flexibility driven by susceptibility to proactive interference. As these impairments are in domains critically dependent on the prefrontal cortex, our findings support prefrontal cortical dysfunction as a prominent feature of neurocognitive aging. This work positions the marmoset as a key model for understanding the neural underpinnings of cognitive aging.
Assessment of protein s and c level and its relationship with health-related factors in people living with hiv: a cross-sectional study
Authors: Rezaei Esmaeil , Jamali Elham , Foroozanfar Zohre , Ataei Farangis , Beheshti Shohre , Joulaei Hassan 
Published: August 2023

Introduction. Not only does Human Immunodeficiency Virus (HIV) threaten the complications associated with immunodeficiency, but also does it cause a set of chronic conditions that may lead to serious problems in these patients. Hypercoagulable state and other hematologic manifestations are reported as leading factors in various clinical problems like deep vein thrombosis in People Living with HIV (PLHIV). The present study aimed to investigate whether there is any correlation between proteins S and C levels (the thrombophilic conditions in HIV seropositive cases) and hematological factors, biochemical markers, CD4 count, HIV viral load, anti-retroviral therapy, Hepatitis C (HCV) and hepatitis B (HBV) confection, drug use, infectious diseases, and demographic characteristics.
Materials and methods. Protein S and C levels in 100 PLHIV were measured. Coagulation tests, CD4 count, HIV viral load, biochemical and hematological factors, and infectious tests were measured in these cases to assess any possible correlation between these factors and the patients proteins S and C levels.
Results. Protein S, and C deficiency among PLHIV 8% and 10%, respectively. Red blood cell, hemoglobin, hematocrit, fasting blood sugar, and albumin were directly related to protein S, and the patients with positive VDRL significantly had a lower level of protein S. The patients receiving anti-retroviral therapy and those with positive VDRL had a higher level of protein C. CD4 count, prothrombin time, and cholesterol had also a direct correlation with protein C level.
Conclusion. According to our results and the reduction of protein S, protein C, and the other factors affecting the lifestyle of PLHIV, there is an urge to pay special attention to thromboembolic disease. Moreover, there is a more possibility of hemostatic imbalances and coagulation disorders in them.
Adhesiveness of the specific phages to yersiniae cells assessed by optical trapping
Authors: Konyshev Ilya V. , Dudina Lyubov G. , Morozova Nadezhda A. , Byvalov Andrey A. 
Published: August 2023

In recent years, there has been increasing interest in using bacteriophages in the complex therapy of some infectious diseases. Objectively, it is related to the spread of antibiotic resistance and a small number of side effects triggered by phages applied locally and parenterally. Yersiniae are no exception to this rule, but their interaction with virions has not been studied thoroughly. In three types of lytic Yersiniae bacteriophages are used for diagnostic purposes, which differ in specificity, virulence, and morphological features. We evaluated the interaction force between phages and bacteriae by optical trapping.
Materials and methods. Live Yersinia pseudotuberculosis and Y. pestis cells with different LPS structure and preparations of three bacteriophages Pokrovskayas phage, dHerelles phage (also named as the pseudotuberculosis phage) and the phage L-413C were used. The Pokrovskayas phage is well studied and widely used in diagnostics, but the mechanism of its adsorption on Y. pestis and Y. pseudotuberculosis cells is not well-understood. The phage L-413C lyses plague bacteria, while dHerrels phage can lyse both pathogens. Virions were linked to the surface of aminated glass. Optically trapped microbial cells were approached to the glass surface and then retracted in the opposite direction. The amplitude of the leap was recalculated into force through calibration coefficients. The primary data were processed in the program R; statistical analysis was performed using Matlab 7.0 and Statistica 12
Results and discussion. The analysis of histograms revealed the presence of a specific component in the Y. pseudotuberculosisdHerrells phage (Fmean = 7.463.52 pN) system, as well as in all pairs involving plague microbe. In the latter case, the interaction forces were comparable: 8.643.83 pN for dHerelles phage,11.034.22 pN for Pokrovskayas phage, and 10.424.79 pN for phage L-413C. The average detachment force from the substrate treated with bovine serum albumin (BSA) was comparable for both cell types. Our results convincingly prove an opportunity for using the optical trapping to estimate interaction force in other bacteriumphage systems.
Post-COVID-19 complications in kidney transplant recipients
Authors: Shafiekhani Mojtaba , Abolghasemi Sara , Asgharpour Masoumeh , Zare Zahra , Negahban Halimeh , Akbari Roghayeh , Nikoupour Hamed , Roozbeh Jamshid , Oliaie Farshid , Yahyapour Yousef , Geraili Zahra , Barari Mohammad , Ebrahimpour Soheil , Baziboroun Mana 
Published: August 2023

Background. Although most people recover from acute COVID-19 within a few weeks, some have long-lasting clinical problems. The prevalence of these prolonged complications in kidney transplant (KT) recipients has not been determined.
Materials and methods. Six months following of 148 patients with post-COVID-19 syndrome admitted to three centers in Iran (Tehran, Shiraz and Babol) that underwent KT were included in this study. Also, one-hundred COVID-19 patients without KT were included as the control group. The demographic data, medications, and disease course were recorded. The baseline and demographic characteristics were analyzed using the Chi-square test. Moreover, students t-test were utilized to compare case and control groups.
Results. The total number of patients was 248, of which 148 were in the case groups. Hospitalization associated with COVID-19 was for all patients; besides, there were 18 patients in control and 24 case groups admitted to an intensive care unit (ICU). The most commonly reported symptom was fever. Multivariate analysis identified the history of chronic kidney disease, hypertension, cerebral vascular accident, and diabetes mellites as predictors for developing post-COVID clinical complications.
Conclusion. Evidence shows the high commonness of post-COVID-19 syndrome among kidney transplant patients after COVID-19, and the most common symptoms were fever, chills, and myalgia. So, all patients recovered from acute COVID-19 should undergo long-term monitoring to evaluate and treat possible complications.
Arabic Online Course Program Management on Ahlan Course
Authors: Maf'udah Syafiyatul , Sujefri Alfan , Kholid Nur 
Published: August 2023

One of the informal learning platforms in Arabic learning is learning courses. The online Arabic course program has a rapid development during the Covid-19 pandemic until now. This wascreated to support Arabic language learning which is carried out at home. Users of this learning service certainly have quite a lot of enthusiasts. Therefore it certainly has special program management to control the activities that take place in it. This research intends to find out how the management process is in this program and analyze the problems faced. The method used is a qualitative approach. Data collection techniques in the form of interviews, observations, and documentation. The results showed that the management in this course has 4 stages in the form of 1) planning; establishment of programs and materials taught, 2) organization; establishment of course schedules and preparation of evaluations and assessments, 3) implementation; providing motivation and guidance between coaches and teachers, teachers and students, as well as communication related to problems on social media, 4) control; evaluation and refinement of the curriculum used in the course.
An Examination of the Acute Effects of Static Stretching Duration on Gastrocnemius Muscle Blood Flow by Superb Microvascular Imaging Method
Authors: UZUN AKKAYA Kamile , ESER AKKAYA Habip 
Published: August 2023

AIM: Static stretching (SS) exercises are frequently used to increase muscle flexibility, improve physical performance, and reduce musculoskeletal injuries. The purpose of this study was to examine the acute effects of different SS duration applied to the gastrocnemius muscle on muscle blood flow by superb microvascular imaging (SMI) method and compare the impact of stretching at different duration immediately after stretching and 10 minutes later.
MATERIAL AND METHOD: 30 healthy volunteers aged between 18-35 years were included in this study. The individuals were divided into two groups randomly. 2-minute SS was applied to the gastrocnemius muscle of the first group, and 5-minute SS was performed to the gastrocnemius muscle of the second group. Blood flow in the muscle after stretching was evaluated by the SMI method.
RESULTS: It was obtained that muscle blood flow raised as a result of stretching applications for 2 minutes and 5 minutes, stretching application for 5 minutes increased blood flow more than stretching application for 2 minutes (p0.05).
CONCLUSION: It was thought that 2 or 5 minutes of stretching applications to increase circulation in healthy individuals might be sufficient.
Evaluation of Patients aged over 65 years who applied to Ankara Training and Research Hospital Family Medicine Outpatient Clinics: Comparison Before and After Covid-19 Pandemic
Authors: ÇAKIT Mehmet Onat , ARSLAN İsmail 
Published: August 2023

Aim: Taking into account the importance and priority of the geriatric age group, the aim of our study was to examine the reasons for and the number of visits to primary health care institutions, to compare them before and after the Covid-19 pandemic, and to draw attention to the importance of geriatric sciences in family medicine specialty training in the light of this evaluation.

Materials and Methods: Patients who applied to the Ankara Training and Research Hospital (EAH) Family Medicine Outpatient Clinics between 01.03.2020-31.12.2022 constitute the population of the study. Patients were retrospectively evaluated before and after the Covid-19 pandemic according to their admission rates and diagnoses. The outpatient clinics they applied to were analyzed. Musculoskeletal system problems were analyzed under a separate heading according to diagnoses.
Results: Out of 47014 diagnoses above the age of 65 during the pandemic period, I10 - Essential (Primary) Hypertension was the most common diagnosis, except for general medical examinations and screening examinations. In the post-Covid-19 period, 45928 diagnoses were made in 14398 patients over the age of 65. After general medical and laboratory examinations, the most common diagnose was I10 Essential Hypertension in both period. Musculoskeletal complaint during the pandemic period was the second most common with the diagnosis of M79.1 Myalgia in both period. Musculoskeletal complaints especially myalgia was more common in the pandemic period than the post-covid period (p
MALE BREAST CANCER: A RETROSPECTIVE ANALYSIS OF SINGLE CENTER RESULTS
Authors: BAYSAL Hakan , ERGÜN Ayşegül , BAYSAL Begümhan , TARCAN Zeynep Çağla , ÖZSOY Mehmet Sait , BÜYÜKER Fatih , ALİMOĞLU Orhan 
Published: August 2023

AIM
Male breast cancers (MBC), constituting less than 1% of all breast carcinomas, are relatively rare. The average age of diagnosis is between 60-70 years and can affect males of all ages. In this study our aim was to present the clinicopathological characteristics, treatment, and survival outcomes of patients who were treated and followed up for ten years in out clinic, in accordance with literature.
MATERIAL AND METHOD
Records of MBC patients who were followed and treated at our clinic between January 2014 and January 2023 were examined retrospectively using the hospital database. Clinicopathological characteristics, treatments performed, overall and disease-free survival rates were analyzed.
RESULTS
A total of 19 patients were included in the study (mean age: 75.9±11.5, range: 57-96). Four patients with distant metastasis and other system malignancies at the time of diagnosis were excluded. The mean follow-up period was 43.8 months. The most common location of the tumor was to be the retroareolar region (63.2%). BRCA2 gene mutation analysis was positive in three patients. Eleven patients (57.9%) were at Stage 3. Eleven patients had invasive ductal carcinoma. Twelve patients belong to the luminal B subtype. Among the 13 patients who underwent axillary dissection 9 (69.2%) had lymph node involvement. Patients who developed distant metastasis had higher overall mortality and cancer-specific mortality. The body mass index (BMI) of deceased patients was lower than that of surviving patients during the follow-up period. Age group above 75 years had lower overall survival (log-rank p=0.0064) and cancer-specific survival (log-rank p=0.011).
CONCLUSION
In our study, we found that distant metastasis significantly affected the survival. Although male breast cancers are rare, early diagnosis, as in women, positively influences overall and disease-free survival.
Pemodelan struktur bawah permukaan berdasarkan data anomali magnetik tereduksi ke kutub di kawasan prospek bijih emas desa paningkaban kecamatan Gumelar kabupaten Banyumas
Authors: Shabrina Syimah Nur Rahmah , Sehah Muhammad , Raharjo Sukmaji Anom 
Published: August 2023

Penelitian dilakukan di kawasan prospek bijih emas Desa Paningkaban, Kecamatan Gumelar, Kabupaten Banyumas. Penelitian bertujuan untuk memetakan data anomali magnetik dan memodelkan struktur geologi bawah permukaan secara dua dimensi (2D) berdasarkan analisis tilt derivative data anomali magnetik yang tereduksi ke kutub. Filter tilt derivative berfungsi untuk mempertegas batas struktur geologi khususnya sesar dan batuan intrusi, sehingga mempermudah proses interpretasi data anomali magnetik. Pengolahan data medan magnetik dilakukan hingga diperoleh data anomali magnetik lokal. Selanjutnya data anomali lokal direduksi ke kutub, sehingga diperoleh nilai anomali magnetik lokal tereduksi ke kutub sebesar -381,8 nT – 218,7 nT. Berdasarkan analisis tilt derivative, pola kontras sebaran anomali yang bernilai tinggi berada dalam arah timur – barat. Hal ini diinterpretasi sebagai pola sebaran struktur sesar dan tubuh batuan intrusi di daerah penelitian yang merupakan jalur mineralisasi emas. Pemodelan 2D telah dilakukan menggunakan software Geosoft Oasis Montaj v. 8.4 untuk mengetahui model struktur geologi bawah permukaan pada Lintasan AA¢, BB¢, dan CC¢. Hasil-hasil pemodelan 2D menunjukkan bahwa pada Lintasan AA¢ terdapat satu batuan intrusi andesit, Lintasan B-B’ terdapat dua batuan intrusi andesit, dan Lintasan C-C’ terdapat satu batuan intrusi dan satu sesar. Batuan intrusi tersebut diperkirakan merupakan lokasi terjadinya mineralisasi emas
Authors: Hartono Hartono , Abdullatif Farzand , Aziz Abdullah Nur , Iksan Sahrul 
Published: August 2023

A DC-DC converter that generates high-voltage DC from a 12 V power supply has been built. Designed using the pulse width modulation (PMW) method in push-pull configuration, the load characteristic of the DC-DC converter was studied. Four The system consists of four main circuits, i.e. the TL594 IC multivibrator circuit, the TLP250 optocoupler MOSFET driver circuit, the MOSFET switching circuit, and the KBP-206 diode bridge rectifier circuit. The system is powered by a 12 V 7,2 Ah battery with a 25 kHz switching frequency. An ETD29 ferrite is used for the high-frequency step-up transformer. Conducted by placing the system under a loading test ranging from 2 kohm to 50 kOhm, the study found that the converter yields a 335 V voltage output at open conditions, and its voltage drops to 10% from its normal value as it draws a current of 91,86mA.
A large quantitative analysis of written language challenges the idea that all languages are equally complex
Authors: Koplenig Alexander , Wolfer Sascha , Meyer Peter 
Published: August 2023

Abstract
One of the fundamental questions about human language is whether all languages are equally complex. Here, we approach this question from an information-theoretic perspective. We present a large scale quantitative cross-linguistic analysis of written language by training a language model on more than 6,500 different documents as represented in 41 multilingual text collections consisting of ~3.5 billion words or ~9.0 billion characters and covering 2,069 different languages that are spoken as a native language by more than 90% of the world population. We statistically infer the entropy of each language model as an index of what we call average prediction complexity. We compare complexity rankings across corpora and show that a language that tends to be more complex than another language in one corpus also tends to be more complex in another corpus. In addition, we show that speaker population size predicts entropy. We argue that both results constitute evidence against the equi-complexity hypothesis from an information-theoretic perspective.
Molecular Anchoring of Free Solvents for High-Voltage and High-Safety Lithium Metal Batteries
Authors: Ren Xiaodi , Cui Zhuangzhuang , Jia Zhuangzhuang , Ruan Digen , Nian Qingshun , Fan Jiajia , Chen Shunqiang , He Zixu , Wang Dazhuang , Jiang Jinyu , Ma Jun , Ou Xing , Jiao Shuhong , Wang Qingsong 
Published: August 2023

Abstract
Constraining the electrochemical reactivity of free solvent molecules is pivotal for developing high-voltage lithium (Li) metal batteries, especially for ether solvents with high Li metal compatibility but low oxidation stability (<4.0 V vs Li+/Li). The typical high concentration electrolyte approach relies on nearly saturated Li+ coordination to ether molecules, which is confronted with severe side reactions under high voltages (>4.4 V) and extensive exothermic reactions between Li metal and reactive anions. Herein, we propose a molecular anchoring approach to restrict the interfacial reactivity of free ether solvents in diluted electrolytes. The hydrogen-bonding interactions from the anchor solvent effectively suppress excessive ether side reactions and increases the electrolyte oxidation onset potential beyond 4.7 V, despite the extremely low Li+/ether molar ratio (1:9). This molecular anchoring dilute electrolyte (MADE) design greatly enhances the cycling performance of 4.7 V-class Li metal batteries with nickel-rich cathodes, while not depending on the typical anion-derived interphase. Furthermore, the exothermic processes under thermal abuse conditions are mitigated due to the reduced reactivity of anions compared to those in concentrated electrolytes, which effectively postpones the thermal runaway of Li metal batteries. This work provides new insights into modulating molecular interactions for rational electrolyte design and a generic strategy for developing high-voltage and high-safety Li metal batteries.
Advancements in the Analytical Methods for Ripasudil Hydrochloride
Hydrate and Timolol Maleate: A Recently Approved FDC
Authors: Patel Khushbu , Kotadiya Rajendra 
Published: August 2023

Abstract:
Fixed-dose Combinations (FDCs) combine two or more medications into a single dosage
form. Several benefits, including impending therapeutic efficacy, a decline in episodes of adverse
drug effects, pharmacokinetic advantages, a decrease in pill burden, a reduction in the dose of individual
medications, and a reduction in the emergence of drug resistance, justify their acceptance. For
the treatment of increased Intraocular Pressure (IOP) in adult patients with open-angle glaucoma or
ocular hypertension, an FDC eye drop formulation, including ripasudil hydrochloride hydrate
(0.4%W/V) and timolol maleate (0.5%W/V) has just received approval. No analytical method has
been reported thus far for this newly approved combination. Thus, this review collected and simplified
information on reported analytical techniques and physicochemical and biological properties for the
above-cited FDCs. The authors have explored various authenticated scientific journals and presented
simplified information to meet the objectives. In this study, the reported methods are spectroscopy
(nil, 23%), HPTLC (nil, 10%), HPLC (100%, 61%), hyphenated techniques (nil, 6%) and electrophoresis
methods (nil, 6%) for ripasudil hydrochloride hydrate and timolol maleate, respectively. Analysts
using such comprehensive data might develop a method for analyzing the recently approved FDCs.