bluuebunny/crossref_metadata_2025_split huggingface dataset:
Progression‐associated molecular changes in basal/squamous and sarcomatoid bladder carcinogenesis
Authors: Fontugne Jacqueline , Wong Jennifer , Cabel Luc , Neyret‐Kahn Hélène , Karboul Narjesse , Maillé Pascale , Rapinat Audrey , Gentien David , Nicolas André , Baulande Sylvain , Sibony Mathilde , Bernard‐Pierrot Isabelle , Radvanyi François , Allory Yves 
Published: January 2023

AbstractThe aggressive basal/squamous (Ba/Sq) bladder cancer (BLCA) subtype is often diagnosed at the muscle‐invasive stage and can progress to the sarcomatoid variant. Identification of molecular changes occurring during progression from non‐muscle‐invasive BLCA (NMIBC) to Ba/Sq muscle‐invasive BLCA (MIBC) is thus challenging in human disease. We used the N‐butyl‐N‐(4‐hydroxybutyl)‐nitrosamine (BBN) mouse model of Ba/Sq MIBC to study longitudinally the molecular changes leading to the Ba/Sq phenotype and to the sarcomatoid variant using IHC and microdissection followed by RNA‐seq at all stages of progression. A shift to the Ba/Sq phenotype started in early progression stages. Pathway analysis of gene clusters with coordinated expression changes revealed Shh signaling loss and a shift from fatty acid metabolism to glycolysis. An upregulated cluster, appearing early in carcinogenesis, showed relevance to human disease, identifying NMIBC patients at risk of progression. Similar to the human counterpart, sarcomatoid BBN tumors displayed a Ba/Sq phenotype and epithelial–mesenchymal transition (EMT) features. An EGFR/FGFR1 signaling switch occurred with sarcomatoid dedifferentiation and correlated with EMT. BLCA cell lines with high EMT were the most sensitive to FGFR1 knockout and resistant to EGFR knockout. Taken together, these findings provide insights into the underlying biology of Ba/Sq BLCA progression and sarcomatoid dedifferentiation with potential clinical implications. © 2023 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland.
Use of gemcitabine, oxaliplatin, and anti‐CD20 therapy in children and adolescents with non‐Hodgkin lymphoma unfit for intensive therapy
Authors: Bender Jonathan D. , Rubinstein Jeremy D. , Mizukawa Benjamin , Perentesis John P. , Pommert Lauren 
Published: January 2023

AbstractMultiagent immunochemotherapy affords excellent outcomes in pediatric non‐Hodgkin lymphoma (NHL); however, scarce data exist for patients unfit for intensive treatment. Rituximab, gemcitabine, and oxaliplatin (R‐GemOx) is well tolerated and efficacious in elderly adults with NHL; however, its use has not been described in pediatrics. In this retrospective, single‐center study, six children with mature B‐cell NHL and significant comorbidities received anti‐CD20 therapy with GemOx (rituximab or obinutuzumab or ofatumumab with gemcitabine and oxaliplatin [R/O‐GemOx]). R/O‐GemOx was well tolerated and resulted in complete response in two of three patients with newly diagnosed NHL and one of three patients with primary refractory NHL. R/O‐GemOx is a viable treatment option for children with NHL who cannot tolerate intensive therapy.
The effect of teacher, parental, and peer support on later grade point average: The mediating roles of self‐beliefs
Authors: Kristensen Sara M. , Jørgensen Magnus , Meland Eivind , Urke Helga B. 
Published: January 2023

AbstractThe present study investigates how perceived support from peers, parents, and teachers influences later academic performance and if academic self‐efficacy and entity intelligence beliefs mediate this association in a sample of early secondary school students. Data were collected from 750 Norwegian students in lower secondary school at two‐time points (8th and 10th grade). All support variables were positively associated with academic self‐efficacy but not entity intelligence beliefs. Academic self‐efficacy was positively associated with GPA in 10th grade, while entity intelligence beliefs were negatively associated. The only mediation effect observed was between teacher support and GPA through academic self‐efficacy. The study offers knowledge about mechanisms of support and later GPA, emphasizing the vital role of teachers in promoting academic self‐efficacy and, in turn, improving academic performance for young adolescents. Entity intelligence beliefs hamper GPA, but more research is needed to ascertain its effect on academic performance.
Dual Drug Loaded Nanotheranostic Platforms as a Novel Synergistic Approach to Improve Pancreatic Cancer Treatment
Authors: Barui Sugata , Conte Marzia , Percivalle Nicolò Maria , Montero Rocío María García , Racca Luisa , Allione Marco , Cauda Valentina 
Published: January 2023

AbstractThis study focuses on the development of theranostic, dual drug‐loaded nanocarriers to propose a proof‐of‐principle therapeutic approach in the treatment of pancreatic ductal adenocarcinoma (PDAC). The nanoconstructs consist of a core of zinc oxide nanocrystals doped with gadolinium, useful as a potential contrast agent in magnetic resonance imaging applications. After functionalizing their surface with amino‐propyl groups, the physical adsorption of two hydrophobic drugs is performed: Vismodegib and Sorafenib. Their synergistic use might improve PDAC treatment and stroma depletion when co‐delivered in the tumor microenvironment for future in vivo applications. To enhance the nanoconstructs’ biostability, the ensemble is coated by a lipid bilayer and a tumor targeting peptide is incorporated on the outer shell surface. As a first proof of concept, the resulting nanoconstructs are tested against two pancreatic cancer cell lines, showing a modest increase in treatment efficacy compared to the free drug counterparts and proving to spare healthy pancreatic cells. In a second testing set, the dual‐drug loaded nanoconstructs are tested on both cell lines previously sensitized to a first‐line chemotherapeutic drug, Gemcitabine, showing an improved treatment response. From these preliminary results, the nanotheranostic platforms might constitute a good starting point for future PDAC therapy and diagnosis studies.
The Mechanisms of Oxygen Accelerated Low‐Temperature Bonding by Ag Nanoparticles
Authors: Wang Wengan , Zou Guisheng , Chen Na , Jia Qiang , Feng Bin , Zhang Hongqiang , Deng Zhongyang , Liu Lei 
Published: January 2023

AbstractLow‐temperature bonding (≤300 o C) using Ag nanoparticles (Ag NPs) is considered to be the new generation of bonding technology in power electronics. The oxygen‐accelerated sintering has been observed by many researchers which is attributed to the decomposition of organics covered on Ag NPs. In this work, organic‐free Ag NPs are fabricated to eliminate the influence of organics, and it is found that the accelerated bonding process by oxygen is strongly correlated to the self‐confined amorphous Ag‐O compound shell on the surface of Ag NPs. In experiments, the sintering process is apparently accelerated by the elevating oxygen content, and the amorphous shell is observed after sintering, which do not grow thicker even in pure oxygen ambient for a long time while performing active chemical evolutions. In simulations, the results match well with the experiments and indicate that the amorphous shell performed the dynamic oxidation and decomposition process. This dynamic equilibrium is caused by the instability of silver oxides, which would enable the amorphous shell to activate the mobility of the surface mass flow and promote the surface diffusion. The shear strength of SiC chip increased by 354% when bonding in pure oxygen, targeting a broad variety of applications in electronic packaging.
MnCO3 Cuboids from Spent LIBs: A New Age Displacement Anode to Build High‐Performance Li‐Ion Capacitors
Authors: Natarajan Subramanian , Akshay Manohar , Aravindan Vanchiappan 
Published: January 2023

AbstractThe advantage of hybridizing battery and supercapacitor electrodes has succeeded recently in designing hybrid charge storage systems such as lithium‐ion capacitors (LICs) with the benefits of higher energy than supercapacitors and more power density than batteries. However, sluggish Li‐ion diffusion of battery anode is one of the main barriers and hampers the development of high‐performance LICs. Herein, is introduced a new conversion/displacement type anode, MnCO3, via effectively recycling spent Li‐ion batteries cathodes for LICs applications. The MnCO3 cuboids are regenerated from the spent LiMn2O4 cathodes by organic acid lixiviation process, and hydrothermal treatment displays excellent reversibility of 535 mAh g−1 after 50 cycles with a Coulombic efficiency of >99%. Later, LIC is assembled with the regenerated MnCO3 cubes in pre‐lithiated form (Mn0 + Li2CO3) as anode and commercial activated carbon (AC) as the cathode, delivering a maximum energy density of 169.4 Wh kg−1 at 25 °C with ultra‐long durability of 15,000 cycles. Even at various atmospheres like −5 and 50 °C, this LIC can offer a energy densities of 53.8 and 119.5 Wh kg−1, respectively. Remarkably, the constructed AC/Mn0 + Li2CO3‐based LIC exhibits a good cycling performance for a continuous 1000 cycles with >91% retention invariably for all temperature conditions.
Integrated Uniformly Microporous C4N/Multi‐Walled Carbon Nanotubes Composite Toward Ultra‐Stable and Ultralow‐Temperature Proton Batteries
Authors: Yang Mingsheng , Zhao Qian , Ma Huige , Li Rui , Wang Yan , Zhou Rongkun , Liu Jieyuan , Wang Xinyu , Hao Yuxin , Ren Jiayi , Zheng Zilong , Zhang Naibo , Hu Mingjun , Luo Jun , Yang Jun 
Published: January 2023

AbstractBenefiting from the proton's small size and ultrahigh mobility in water, aqueous proton batteries are regarded as an attractive candidate for high‐power and ultralow‐temperature energy storage devices. Herein, a new‐type C4N polymer with uniform micropores and a large specific surface area is prepared by sulfuric acid‐catalyzed ketone amine condensation reaction and employed as the electrode of proton batteries. Multi‐walled carbon nanotubes (MWCNT) are introduced to induce the in situ growth of C4N, and reaped significantly enhanced porosity and conductivity, and thus better both room‐ and low‐temperature performance. When coupled with MnO2@Carbon fiber (MnO2@CF) cathode, MnO2@CF//C4N‐50% MWCNT full battery shows unprecedented cycle stability with a capacity retention of 98% after 11 000 cycles at 10 A g−1 and even 100% after 70 000 cycles at 20 A g−1. Additionally, a novel anti‐freezing electrolyte (5 m H2SO4 + 0.5 m MnSO4) is developed and showed a high ionic conductivity of 123.2 mS cm−1 at ‐70 °C. The resultant MnO2@CF//C4N‐50% MWCNT battery delivers a specific capacity of 110.5 mAh g−1 even at ‐70 °C at 1 A g−1, the highest in all reported proton batteries under the same conditions. This work is expected to offer a package solution for constructing high‐performance ultralow‐temperature aqueous proton batteries.
Low‐Power, Multi‐Transduction Nanosensor Array for Accurate Sensing of Flammable and Toxic Gases
Authors: Henriquez Dionisio V. Del Orbe , Kang Mingu , Cho Incheol , Choi Jungrak , Park Jaeho , Gul Osman , Ahn Junseong , Lee Dae‐Sik , Park Inkyu 
Published: January 2023

AbstractToxic and flammable gases pose a major safety risk in industrial settings; thus, their portable sensing is desired, which requires sensors with fast response, low‐power consumption, and accurate detection. Herein, a low‐power, multi‐transduction array is presented for the accurate sensing of flammable and toxic gases. Specifically, four different sensors are integrated on a micro‐electro‐mechanical‐systems platform consisting of bridge‐type microheaters. To produce distinct fingerprints for enhanced selectivity, the four sensors operate based on two different transduction mechanisms: chemiresistive and calorimetric sensing. Local, in situ synthesis routes are used to integrate nanostructured materials (ZnO, CuO, and Pt Black) for the sensors on the microheaters. The transient responses of the four sensors are fed to a convolutional neural network for real‐time classification and regression of five different gases (H2, NO2, C2H6O, CO, and NH3). An overall classification accuracy of 97.95%, an average regression error of 14%, and a power consumption of 7 mW per device are obtained. The combination of a versatile low‐power platform, local integration of nanomaterials, different transduction mechanisms, and a real‐time machine learning strategy presented herein helps advance the constant need to simultaneously achieve fast, low‐power, and selective gas sensing of flammable and toxic gases.
Isothermal and Kinetic Modeling for Uptake of Heavy Metal Ion from Aqueous Solution Using Succinylated Polysaccharide
Authors: Abbas Azhar , Siddique Abu Bakar , Batool Rabia , Sher Muhammad , Irfan Muhammad Imran , Abbas Muhammad Azhar 
Published: January 2023

AbstractHeavy metals are posing a serious threat to public health. Due to leaching and widespread use in chemical industries, their concentration is continuously increasing in fresh water reservoirs and industrial effluents. To address the severity of this issue, there is a dire need to devise the economic and environment friendly strategies to remove or decrease the concentration of heavy metals in water reservoirs. In the current research work, an economic and environment friendly polymer, succinylated microcrystalline cellulose (MCCS) is synthesized and modified for the adsorption of Cd(II) ions from aqueous solution. The sodium salt of MCCS (MCCSNa) shows good adsorption capacity for Cd(II) ions through ion‐exchange phenomenon. Isothermal modeling using different adsorption isotherms is investigated to check the spontaneity and understand the insight phenomenon of adsorption. Kinetic modeling of sorption phenomenon is performed to optimize the adsorption conditions for efficient removal of heavy metal ions. Moreover, regeneration capacity of the sorbent is also determined for its reuse to remove heavy metals.
Debating Population in and Beyond Feminist Political Ecology
Authors: Fenner Mila , Harcourt Wendy 
Published: January 2023

AbstractIn this chapter, we explore the topic of population in the context of the latest work by renowned feminist STS scholar Donna Haraway and her call to ‘make kin not babies’. We reflect on the explosive reactions among feminists to Haraway’s recent work by paying attention to emotions in population debates among feminist thinkers. Using an informal dialogue format, we engage at both a personal and scholarly level to map out the contours of feminist thinking about the fraught topic of population growth and population control.
No room to hide: implications of cosmic-ray upscattering for GeV-scale dark matter
Authors: Alvey James , Bringmann Torsten , Kolesova Helena 
Published: January 2023

Abstract
The irreducible upscattering of cold dark matter by cosmic rays opens up the intriguing possibility of detecting even light dark matter in conventional direct detection experiments or underground neutrino detectors. The mechanism also significantly enhances sensitivity to models with very large nuclear scattering rates, where the atmosphere and rock overburden efficiently stop standard non-relativistic dark matter particles before they could reach the detector. In this article, we demonstrate that cosmic-ray upscattering essentially closes the window for strongly interacting dark matter in the (sub-)GeV mass range. Arriving at this conclusion crucially requires a detailed treatment of both nuclear form factors and inelastic dark matter-nucleus scattering, as well as including the full momentum-transfer dependence of scattering amplitudes. We illustrate the latter point by considering three generic situations where such a momentum-dependence is particularly relevant, namely for interactions dominated by the exchange of light vector or scalar mediators, respectively, and for dark matter particles of finite size. As a final concrete example, we apply our analysis to a putative hexaquark state, which has been suggested as a viable baryonic dark matter candidate. Once again, we find that the updated constraints derived in this work close a significant part of otherwise unconstrained parameter space.
Perturbative running of the topological angles
Authors: Valenti Alessandro , Vecchi Luca 
Published: January 2023

Abstract
We argue that in general renormalizable field theories the topological angles may develop an additive beta function starting no earlier than 2-loop order. The leading expression is uniquely determined by a single model-independent coefficient. The associated divergent diagrams are identified and a few methods for extracting the beta function in dimensional regularization are discussed. We show that the peculiar nature of the topological angles implies non-trivial constraints on the anomalous dimension of the CP-violating operators and discuss how a non-vanishing beta function affects the Weyl consistency conditions. Some phenomenological considerations are presented.
Photon orbits and phase transition for non-linear charged anti-de Sitter black holes
Authors: Du Yun-Zhi , Li Huai-Fan , Liu Fang , Zhang Li-Chun 
Published: January 2023

Abstract
In this work, we investigate the relation between the photon sphere radius and the first-order phase transition for the charged Einstein-power-Yang-Mills AdS black hole. Through the analysis, we find with a certain condition there exist the non-monotonic behaviors between the photon sphere radius, the impact parameter, the non-linear Yang-Mills charge parameter, temperature, and pressure. And both the changes of photon sphere radius and impact parameter before and after phase transition can be regarded as the order parameter, their critical exponents near the critical point are equal to the same value 1/2, just like the ordinary thermal systems. These indicate that there maybe exists a universal relation of gravity nearby the critical point for a black hole thermodynamical system. Furthermore, the effect of impact parameter on the deflect angle is also investigated.
Type 2 transglutaminase in the nucleus: the new epigenetic face of a cytoplasmic enzyme
Authors: Rossin Federica , Ciccosanti Fabiola , D’Eletto Manuela , Occhigrossi Luca , Fimia Gian Maria , Piacentini Mauro 
Published: January 2023

AbstractOne of the major mysteries in science is how it is possible to pack the cellular chromatin with a total length of over 1 m, into a small sphere with a diameter of 5 mm “the nucleus”, and even more difficult to envisage how to make it functional. Although we know that compaction is achieved through the histones, however, the DNA needs to be accessible to the transcription machinery and this is allowed thanks to a variety of very complex epigenetic mechanisms. Either DNA (methylation) or post-translational modifications of histone proteins (acetylation, methylation, ubiquitination and sumoylation) play a crucial role in chromatin remodelling and consequently on gene expression. Recently the serotonylation and dopaminylation of the histone 3, catalyzed by the Transglutaminase type 2 (TG2), has been reported. These novel post-translational modifications catalyzed by a predominantly cytoplasmic enzyme opens a new avenue for future investigations on the enzyme function itself and for the possibility that other biological amines, substrate of TG2, can influence the genome regulation under peculiar cellular conditions. In this review we analyzed the nuclear TG2’s biology by discussing both its post-translational modification of various transcription factors and the implications of its epigenetic new face. Finally, we will focus on the potential impact of these events in human diseases.
Mobile Gesundheitstechnologien, soziale Gerechtigkeit und populationsbezogene Vulnerabilitäten
Authors: Jansky Bianca , Machleid Felix , Wild Verina 
Published: January 2023

ZusammenfassungMobile Gesundheitstechnologien (mHealth) fördern den Trend hin zu Eigenverantwortung und Selbstmanagement. Ziel des Beitrags ist es, am Beispiel von Diabetes mellitus Typ 2 (T2DM) die Diskussion zu mHealth, Eigenverantwortung und Gerechtigkeit – welche es bisher nur in Ansätzen gibt – aus einer Public-Health-ethischen Perspektive zu vertiefen. Dabei zeigt sich, dass mHealth im Bereich T2DM soziale Gesundheitsgerechtigkeit einerseits verbessern, andererseits aber auch soziale Gesundheitsungerechtigkeiten verschärfen kann. Aus einer gerechtigkeitsfokussierten, Public-Health-ethischen Perspektive auf T2DM-mHealth ist es notwendig, besser zu verstehen, ob und wie vulnerable Bevölkerungsgruppen bei mHealth-Entwicklung und -Einsatz mitbedacht werden, wie sie die Nutzung der Technologie erleben, welche sozialepidemiologischen Auswirkungen der zunehmende Einsatz von mHealth haben kann, welche gesundheitlichen Ungleichheiten im Bereich T2DM ungerecht sind, inwieweit die Eigenverantwortung in die Hände der Nutzenden gelegt werden soll und wo die Grenzen der Eigenverantwortung liegen. Die Berücksichtigung der sozialen Diversität und der sozialen Determinanten von Gesundheit ist ein stetiger Prozess und muss alle Phasen der Entwicklung und des Einsatzes von mHealth durchziehen.
Myalgische Enzephalomyelitis/chronisches Fatigue-Syndrom: eine Übersicht zur aktuellen Evidenz
Authors: Ludwig Birgit , Olbert Elisabeth , Trimmel Karin , Seidel Stefan , Rommer Paulus S. , Müller Christian , Struhal Walter , Berger Thomas 
Published: January 2023

ZusammenfassungIn den vergangenen 5 Jahren hat sowohl das mediale als auch das wissenschaftliche Interesse an der Erkrankung myalgische Enzephalomyelitis/„chronic fatigue syndrome“ (ME/CFS) signifikant zugenommen; nicht zuletzt auch durch die klinisch ähnliche Manifestation im Rahmen von Long- oder Post-COVID. In dieser Übersichtsarbeit diskutieren wir die klinische Diagnosestellung und therapeutische Studien zu ME/CFS sowie die Gemeinsamkeiten oder Unterschiede zu Long‑/Post-COVID. Bisher liegen weder pathophysiologisch eindeutig kausale noch therapeutisch evidenzbasierte Ergebnisse in der langjährigen wissenschaftlichen Forschung zu ME/CFS vor. Nicht zuletzt aufgrund der relevanten psychiatrischen Komorbiditätsrate beim ME/CFS ist nach der aktuellen Datenlage eine psychosomatische Ätiologie der Erkrankung zu diskutieren. Des Weiteren könnte sich eine genauere und sichere Diagnosestellung anhand strikterer Diagnosekriterien auf die weitere Forschung und vor allem hinsichtlich Therapien positiv auswirken.