bluuebunny/crossref_metadata_2025_split huggingface dataset:
Root coverage with apical tunnel approach using propolis as a root conditioning agent: A case report with 2‐year follow‐up and review of the literature
Authors: Mandil Obada , Sabri Hamoun , Manouchehri Neshatafarin , Mostafa Diana , Wang Hom‐Lay 
Published: June 2023

AbstractObjectivesOne of the main challenges in performing root coverage is patient discomfort and donor site morbidity. This case report presents a minimally invasive apical tunnel surgical technique, with propolis for root conditioning, to correct gingival recession defects without harvesting donor grafts, flap elevation, or sutures. Propolis is a natural anti‐infective, anti‐inflammatory, and antioxidant agent.Material and MethodsA 58‐year‐old woman with no significant medical history was presented for root coverage of her upper left canine and first premolar with recession type (RT)1A (+). Propolis was used as a root conditioning agent to promote soft tissue coverage via an apical tunnel approach. During the apical tunnel approach, a small apical hole was made 6 mm below the mucogingival junction, and the mucosa and associated attached gingiva was away from the tooth so the flap could be repositioned coronally. Collagen matrix was used as a soft tissue graft material.ResultsAt the 2‐month, 6‐month, 8‐month, and 2‐year follow‐up, complete root coverage was achieved for both teeth. No bleeding on probing was noticed nor recurrent GRs at the treated sites.ConclusionWithout incisions, donor site reflection, or flaps, the apical tunnel approach can be successfully used to cover the exposed roots. Additionally, propolis is a potential root conditioning agent during soft tissue graft procedure due to its anti‐inflammatory and antioxidant properties.
Face‐Dependent Reconstruction of Bi‐Oxyiodides toward Selective Growth of (BiO)2CO3 Edge Side to Maximize CO2 Conversion Efficiency
Authors: Lim Taewaen , Seo Junhyeok 
Published: June 2023

AbstractChemical reconstruction of bismuth oxyiodides using bicarbonates is tried to selectively grow (BiO)2CO3 edge side. Orthorhombic o‐Bi5O7I undergoes a total reconstruction process by its phase transformation into tetragonal (BiO)2CO3 (BOC‐o) to form a well‐aligned nanosheet array with maximally exposing CO32− moiety at the edge side. The post‐reconstruction BOC‐o catalyst achieved 100 % Faradaic efficiency at −0.86 V vs. RHE for CO2‐to‐formate conversion. However, another conservative reconstruction of tetragonal t‐BiOI into tetragonal (BiO)2CO3 (BOC‐t) exposed majorly a less reactive [BiO]+ layer. At low overpotential regions, the catalytic cycle of BOC‐o begins with the initial conversion of the CO32− moiety into formate at the [−OBi−(CO3)−BiO−] site, but at high overpotential regions, the [BiO]+ layer undergoes reduction to metallic Bi and multi‐catalytic species proceed with CO2 reduction. Otherwise, the deactivation of Bi+ site by an organic molecule switched on another catalysis of proton reduction, preventing CO2 reduction.
Prevalence, clinical characteristics and HLA genotypes of idiopathic type 1 diabetes: A cross‐sectional study
Authors: Chen Yan , Xie Yuting , Xia Ying , Xie Zhiguo , Huang Gan , Fan Li , Zhou Zhiguang , Li Xia 
Published: June 2023

AbstractAimsIdiopathic type 1 diabetes (T1D) is a neglected subtype of T1D. Our aim was to investigate the frequency, clinical characteristics, and human leucocyte antigen (HLA) genotypes of idiopathic T1D.MethodsWe enrolled 1205 newly diagnosed T1D patients in our analysis. To exclude monogenic diabetes in autoantibody‐negative patients, we utilised a custom monogenic diabetes gene panel. Individuals negative for autoantibodies and subsequently excluded for monogenic diabetes were diagnosed with idiopathic T1D. We collected clinical characteristics, measured islet autoantibodies by radioligand assay and obtained HLA data.ResultsAfter excluding 11 patients with monogenic diabetes, 284 cases were diagnosed with idiopathic T1D, accounting for 23.8% (284/1194) of all newly diagnosed T1D cases. When compared with autoimmune T1D, idiopathic T1D patients showed an older onset age, higher body mass index among adults, lower haemoglobin A1c, higher levels of fasting C‐peptide and 2‐h postprandial C‐peptide, and were likely to have type 2 diabetes (T2D) family history and carry 0 susceptible HLA haplotype (all p < 0.01). A lower proportion of individuals carrying 2 susceptible HLA haplotypes in idiopathic T1D was observed in the adult‐onset subgroup (15.7% vs. 38.0% in child‐onset subgroup, p < 0.001) and in subgroup with preserved beta‐cell function (11.0% vs. 30.1% in subgroup with poor beta‐cell function, p < 0.001). Multivariable correlation analyses indicated that being overweight, having T2D family history and lacking susceptible HLA haplotypes were associated with negative autoantibodies.ConclusionsIdiopathic T1D represents about 1/4 of newly diagnosed T1D, with adult‐onset and preserved beta‐cell function patients showing lower HLA susceptibility and more insulin resistance.
High‐throughput untargeted screening of biotherapeutic macromolecules in equine plasma by UHPLC‐HRMS/MS: Application to monoclonal antibodies and Fc‐fusion proteins for doping control
Authors: Pinetre Justine , Delcourt Vivian , Becher François , Garcia Patrice , Barnabé Agnès , Loup Benoit , Popot Marie‐Agnès , Fenaille François , Bailly‐Chouriberry Ludovic 
Published: June 2023

AbstractMany innovative biotherapeutics have been marketed in the last decade. Monoclonal antibodies (mAbs) and Fc‐fusion proteins (Fc‐proteins) have been developed for the treatment of diverse diseases (cancer, autoimmune diseases, and inflammatory disorders) and now represent an important part of targeted therapies. However, the ready availability of such biomolecules, sometimes characterized by their anabolic, anti‐inflammatory, or erythropoiesis‐stimulating properties, raises concerns about their potential misuse as performance enhancers for human and animal athletes. In equine doping control laboratories, a method has been reported to detect the administration of a specific human biotherapeutic in equine plasma; but no high‐throughput method has been described for the screening without any a priori knowledge of human or murine biotherapeutic. In this context, a new broad‐spectrum screening method involving UHPLC‐HRMS/MS has been developed for the untargeted analysis of murine or human mAbs and related macromolecules in equine plasma. This approach, consisting of a “pellet digestion” strategy performed in a 96‐well plate, demonstrates reliable performances at low concentrations (pmol/mL range) with high‐throughput capability (≈100 samples/day). Targeting species‐specific proteotypic peptides located within the constant parts of mAbs enables the “universal” detection of human biotherapeutics only by monitoring 10 peptides. As proof of principle, this strategy successfully detected different biotherapeutics in spiked plasma samples, and allowed, for the first time, the detection of a human mAb up to 10 days after a 0.12 mg/kg administration to a horse. This development will expand the analytical capabilities of horse doping control laboratories towards protein‐based biotherapeutics with adequate sensitivity, throughput, and cost‐effectiveness.
Low impact of forest conversion on biodiversity: Evidence from small mammals in contrasting forests of Mt. Liangshan
Authors: He Xingcheng , Wen Zhixin , Zhang Dejun , Yang Qisen , Yin Xudong , Chen Xue , Ran Jianghong 
Published: June 2023

AbstractSecondary and plantation forests are the main alternative forests remaining after the deforestation of primary forests. Understanding the conservation value of secondary and plantation forests is important for biological conservation. To explore the impact of forest conversion on biodiversity, we compared multiple diversity metrics (taxonomic, phylogenetic, and functional diversity) and community structure of small mammals in the primary, secondary, and plantation forests in Mt. Liangshan, Sichuan Province, China. Three field surveys were conducted in each of the three forest types to characterize local small mammal assemblages from 2017 to 2020. We found that the taxonomic, phylogenetic, and functional diversity of small mammals in the three forest types were similar at the landscape scale, while all diversity metrics were lowest in the plantation forest and highest in the primary forests at the site scale. The community structure analysis showed that habitat filtering was the dominant process driving the assembly of small mammal communities across the three forest types, and there was no statistically significant difference in small mammal community structure among the three forest types. Our results indicated that secondary and plantation forests in the nature reserves, adjacent to the primary forest and exposed to little human disturbance, also can provide important habitats for small mammals.
Urban land cover and El Niño events negatively impact population viability of an endangered North American songbird
Authors: Reidy Jennifer L. , Sinnott Emily A. , Thompson Frank R. , O'Donnell Lisa 
Published: June 2023

AbstractPopulation dynamics of migratory species are influenced by land use and climate patterns experienced across the full annual cycle. Identifying environmental factors influencing productivity, survival, and their relative contributions to abundance and population growth is critical for the recovery and management of at‐risk species in the face of continuing global change. The golden‐cheeked warbler (Setophaga chrysoparia) is an endangered passerine that breeds exclusively in the mixed Ashe juniper (Juniperus ashei)–oak (Quercus) woodlands of Central Texas, USA, and winters at high elevations in Central America. We evaluated the effects of precipitation, climate, and land cover on golden‐cheeked warbler productivity, adult male survival, and territory abundance using data from a long‐term monitoring site, the Balcones Canyonlands Preserve, in Austin, Texas. We jointly analyzed annual productivity, mark–recapture, and territory count data collected on 10 plots from 2011 to 2019 in an integrated population model. The number of young fledged per male territory was negatively related to percent urban land cover within 1 km of monitoring plots, and adult male survival was negatively related to a strong El Niño event. Estimates of population growth and abundance indicated a decline in abundance across our study period. We forecasted population viability 25 years into the future given increases in urban development and frequency of El Niño events. Quasi‐extinction probability increased from 0.17 under current urban land cover conditions and El Niño frequency to 0.41 under the scenario of a 10% increase in urban development around all plots and an increase in El Niño frequency. Productivity and adult survival were positively correlated with population growth, highlighting the need for conservation and management actions to maximize these vital rates on the breeding grounds and range‐wide.
Activation of persulfate by iron‐loaded soybean straw biochar for efficient degradation of dye contaminants: Synthesis, performance, and mechanism
Authors: Yang Yuxiao , Zhu Junfeng , Zeng Qingzhu , Yan Mengmeng , Gao Weichun , Li Jinling , Zeng Xiangchu , Zhang Guanghua 
Published: June 2023

AbstractBiochar loaded with metal ions has been widely used to activate persulfate to degrade organic pollutants. However, the preparation conditions of catalysts are always controversial. In this study, the co‐heating conditions of soybean straw with high carbon and low nitrogen and nano‐iron oxide were systematically discussed by response surface method, and an efficient catalyst (Fe@BC) was obtained. Fe@BC can effectively activate sodium persulfate (PS) and degrade three synthetic azo dyes (Methyl orange (MO), Amino black 10B (AB10B), and Orange II) and rhodamine B (RhB). Under the optimum conditions, the removal rate of total organic carbon of these four dyes reached 41.1%–89.8% and the final degradation rate could reach 100%. The physicochemical properties of Fe@BC were studied by SEM, BET, XRD, XPS and TGA. The results revealed that the specific surface area of Fe@BC was 195.6m2/g. Further, reducing iron oxide by C generated C0.09Fe1.91 and zero‐valent iron. Free radical scavenging experiments and electron paramagnetic resonance (EPR) measurements showed that the main reactive oxide species (ROS) in the Fe@BC/PS system were hydroxyl radicals (•OH) and singlet oxygen (1O2). Finally, Several Fe@BC modification systems were explored, the optimum pH of Fe@BC/PS system was analyzed, and the effects of Fe@BC and PS dosage on degradation performance were also studied. This study provides a scientific basis for the production of efficient catalysts and biochar energy, and an effective treatment scheme for printing and dyeing wastewater.
Prediction uncertainty and volatility for carbon price using an adaptive lower and upper bound estimation model
Authors: Yang Jie , Wu Zhiqiang 
Published: June 2023

AbstractThe high volatility and uncertainty of carbon price have always been two major challenges in carbon price forecasting. To solve these two challenges, an adaptive lower‐and upper‐bound estimation (LUBE) model with improved variational mode decomposition (VMD) and PSO‐based interval optimization strategy is proposed for interval prediction of carbon price. To validate effectiveness and superiority, the adaptive LUBE model and several competitive models, including the bootstrap model, delta model, and Bayesian model, were utilized for interval prediction of carbon prices of Beijing and Shanghai. Compared with other models, the adaptive LUBE model not only has excellent coverage but also has the narrowest interval width in both training set and test set. Therefore, the excellent comparison results show that the proposed model can obtain a more reliable and higher‐quality prediction interval, which can be a novel and effective carbon prices forecasting tool for governments and enterprises.
A review on workflow scheduling and resource allocation algorithms in distributed mobile clouds
Authors: Golmohammadi Akram , Kamel Tabbakh Seyed Reza , Ghaemi Reza 
Published: June 2023

AbstractThe advent of distributed computing and mobile clouds made it possible to transfer and distribute the heavy processes of complex workflows to the cloud. Managing and with the help of the mobile cloud, virtualization and shared resources managing the executing large‐scale workflows is possible. Since virtual resources are used, scheduling and resource allocation are important and key research topics in public cloud environment and mobile clouds. The cloud model of mobile devices with public or virtual cloud, which consists of temporary mobile devices, is an interesting topic to be investigated. Workflow scheduling and availability of resources in mobile clouds by high mobility and Energy efficient, it is one of the challenges and problems that must be investigated one of the main challenges in this research area. The purpose of scheduling algorithms is to improve service quality criteria by observing the constraints. In this article, the main goal is to extensively review the scheduling algorithms for the complex scientific workflow in public and mobile clouds. Furthermore, a review of the use of heuristic and meta‐heuristic techniques in dynamic and static states, with various constraints for task scheduling in cloud and mobile computing has been performed. This article accomplishes a review of using existing techniques for scheduling tasks in mobile clouds. We also present a comprehensive analysis and systematic comparison between these scheduling algorithms.
IPAPS: An improved public auditing protocol for secure data storage in cloud‐based medical storage system
Authors: Tang Caiyuan , Wang Feng , Zhao Chenbin , Chen Xiuqiang 
Published: June 2023

AbstractCloud‐based medical storage system is becoming popular. Cloud server is curious about the private information of stored cases, and the integrity of outsourced data has become increasingly concerned. Numerous public auditing protocols for the outsourced data into the cloud server were proposed. Unfortunately, in the existing protocols, some of them may neglect security to improve efficiency. Recently, Li et al. proposed an efficient privacy‐preserving public auditing protocol for cloud‐based medical storage system (EPPAP), which improved the communication efficiency by storing some of data owner's data in third part auditors, however we find that the protocol is vulnerable to collusion attack and replace attack. In this paper, we analyze the security attacks of the existing protocol, and further propose an improved public auditing protocol for secure data storage in cloud‐based medical storage system (IPAPS). In addition, we give the formal security proof and analyze the performance of our proposed protocol. The security proof shows our protocol takes into account integrity, collusion attack and replace attack at the same time. The simulation experiments in our performance analysis show that the proposed protocol is practical.
Willingness to pay brand premiums for generic medicines in Kenya: A bidding game experiment
Authors: Rockers Peter C. , Kiragu Zana Wangari , Onyango Monica A. , Laing Richard O. , Wirtz Veronika J. 
Published: June 2023

AbstractBackgroundRecent growth in the market share of higher priced branded generic medicines in low‐ and middle‐income countries (LMICs) has raised concerns around affordability and access. We examined consumer willingness to pay (WTP) for branded versus unbranded generic non‐communicable disease (NCD) medicines in Kenya.MethodsWe randomly assigned NCD patients to receive a hypothetical offer for either a Novartis Access‐branded medicine or for an unbranded generic equivalent. We then analysed WTP data captured using a bidding game methodology.ResultsWe found that WTP for Novartis Access medicines was on average 23% higher than for unbranded generic equivalents (p = 0.009). The WTP brand premium was driven almost entirely by wealthier patients.ConclusionsOur findings suggest that the dominance of branded generics in LMICs like Kenya reflect in part consumer preferences for these medicines. Governments and other health sector actors may be justified in intervening to improve access to these medicines and equivalent non‐branded generics, particularly for the poorest patients who appear to have no preference for branded medicines.
Impact of the government's restrictions and guidance in relation to “social distancing” on the lives of ethnic minority populations: A mixed methods study
Authors: Saini Pooja , Porcellato Lorna , Hunt Anna , Timpson Hannah , Harrison Rebecca , Bigland Charlotte , Levy Conan , Brett Caroline E. , Forshaw Mark J. , Hope Vivian D. ,   The Phoenix Team
Published: June 2023

AbstractBackground and AimsThe impacts of the COVID‐19 pandemic have not been equal, with a disproportionate impact among ethnic minority communities. Structural inequalities in social determinants of health such as housing and employment have contributed to COVID‐19's impact on deprived communities, including many ethnic minority communities. To compare (1) how the UK government's “social distancing” restrictions and guidance were perceived and implemented by ethnic minority populations compared to white populations, (2) the impact of restrictions and guidance upon these groups.MethodsAn explanatory sequential mixed methods study incorporated a quantitative survey and qualitative semi‐structured interviews to explore individual perceptions and experiences of COVID‐19 and the national restrictions. Survey participants (n = 1587) were recruited from North West England; 60 (4%) participants were from ethnic minority communities. Forty‐nine interviews were conducted; 19 (39%) participants were from ethnic minority communities. Interviews were transcribed verbatim and analysed using a thematic approach. Data collection was between April and August 2020.ResultsSignificant differences in demographics and household overcrowding were observed between white vs ethnic minority survey respondents, who were also significantly less confident in their knowledge of COVID‐19, less likely to be high‐risk drinkers, and marginally more likely to have experienced job loss and/or reduced household income. There were no group differences in wellbeing, perceptions, or nonfinancial impacts. Two inter‐related themes included: (1) government guidance, incorporating people's knowledge and understanding of the guidance and their confusion/frustration over messaging; (2) the impacts of restrictions on keyworkers, home‐schooling, working from home and changes in lifestyle/wellbeing.ConclusionsFurther research is needed on the long‐term impacts of COVID‐19 on ethnic minority communities. If policy responses to COVID‐19 are to benefit ethnic minority communities, there is a need for future studies to consider fundamental societal issues, such as the role of housing and economic disadvantage.
Association between interpregnancy interval and gestational diabetes mellitus: A cohort study of the National Vital Statistics System 2020
Authors: Zhu Xuejiao , Li Wei , Xi Hongli , Li Mingqun 
Published: June 2023

AbstractObjectiveTo assess the association between interpregnancy interval (IPI) and gestational diabetes mellitus (GDM).MethodsData of this retrospective cohort study were obtained from the National Vital Statistics System (NVSS) 2020. The participants were divided into different groups according to different IPI (<6, 6–11, 12–17, 18–23, 24–59 (reference), 60–119, ≥120 months). Multivariate logistic models were constructed to evaluate the association between IPI and GDM. Subgroup analysis was further performed.ResultsA total of 1 515 263 women were included, with 123 951 (8.18%) having GDM. Compared with the 24–59 months group, the <6 months (odds ratio [OR] 0.64, 95% confidence interval [CI] 0.46–0.90, P = 0.009), 12–17 months (OR 0.96, 95% CI 0.94–0.98, P < 0.001), and 18–23 months (OR 0.94, 95% CI 0.93–0.96, P < 0.001) groups had a significantly lower risk of GDM, while the 60–119 months (OR 1.13, 95% CI 1.11–1.15, P < 0.001) and ≥120 months (OR 1.18, 95% CI 1.15–1.21, P < 0.001) groups had a significantly higher risk of GDM. No significant difference was observed in the risk of GDM between the 6–11 and 24–59 months groups (P = 0.542). The PI–GDM association varied across different groups of age, pre‐pregnancy body mass index, pre‐pregnancy smoking status, history of cesarean section, history of preterm birth, prior terminations, and parity.ConclusionAn IPI of 18–23 months may be a better interval than 24–59 months in managing the risk of GDM.
Different impact of COVID‐19 on symptomatic pregnant and postpartum women in low‐income countries and low‐ and middle‐income countries
Authors: Mahajan Niraj N. , Ansari Munira , Munshi Hrishikesh , More Pradnya , Gajbhiye Rahul K. 
Published: June 2023

SynopsisThe adverse outcomes of COVID‐19 among pregnant women have been pronounced in the low‐income countries compared with low‐ and middle‐income countries.