bluuebunny/crossref_metadata_2025_split huggingface dataset:
New findings on disease characteristics of multiple myeloma patients with acute renal insufficiency: a ten- year retrospective study
Authors: Wu Tianzhi , Zhao Yongfeng , Wei Shuyi , Zhou Fuling 
Published: April 2023

Abstract
Background 48% of multiple myeloma patients will develop kidney damage, and its progression, survival, hematological characteristics, and cytokine characteristics have not yet been fully characterized. We aimed to describe subgroups of multiple myeloma with acute renal insufficiency and analyze associated predictors.
Methods The patients with acute renal insufficiency were divided into one group, and the remaining were divided into another group. Risk factors were analyzed by comparing the baseline, progression-free survival, and survival outcomes between the two groups. 12 cytokines were detected by flow cytometry, and the relationship between cytokines and renal function was explored.
Results 306 patients with multiple myeloma in Zhongnan Hospital of Wuhan University from 2011 to 2021 were enrolled, including 91 patients with acute renal insufficiency. The baseline of the two groups were well matched. ISS stage and immune typing are important predictors. With the advance of the disease course, the prediction ability of the initial disease stage to the prognosis decreased, but the prediction ability of WBC and β2-MG increased. IL-6 (P=0.001) and κ-light chain (P=0.006) were significantly elevated in patients with acute renal insufficiency, and were closely related to the severity of renal function deterioration (P<0.001).
ConclusionsAcute renal insufficiency seriously affects the prognosis of myeloma patients, among which light chain is an important initiating factor. In addition to ISS staging and immunophenotyping, we propose for the first time the predictive value of leukocytes and IL-6 on disease course. And our study provides important evidence for the development of early blood purification therapy.
Surgical site infection secondary to caesarean section: Case report of unrecognized pyoderma gangrenosum
Authors: Wu Xiaoli , Chen Aner , Tong Yanyan , Wang Yinfen , He Xiaobo 
Published: April 2023

Abstract

Pyoderma gangrenosum(PG) is an uncommon form of ulcerative neutrophilic dermatosisan(ND) presented as painful ulcerated skin at sites of injury or surgery. A 19-year-old primigravida was found signs of ulcerative wound skin defects liking surgical site infection after caesarean section. Despite antibiotic treatment and consecutive debridement procedures were all performed, progressive deterioration of the wound occurred. PG was diagnosed by clinically progressive skin necrosis and negative wound cultures. After several weeks, the abdominal wall defect was surgically corrected with systemic corticosteroid therapy and skin grafting. A sense mutation identified by whole-exome sequencing (WES) was located within NFKB1, chr4:103498062–103498096, which may be related to PG. Postoperative PG can mimic infectious diseases, but the treatment is substantially different. This case of PG highlights the importance of timely recognition and treatment of the disease.
Clinico-mycological study of dermatophytosis among diabetic and non-diabetic patients in a tertiary level hospital – a comparative study
Authors: Rajagopal Abarna , Vinutha Rangappa , Ashwini Padubidri Kombettu , Vidyavathi Chitharagi B , Veeranna Shastry 
Published: April 2023

Abstract

Dermatophytosis is a major public health concern in India, especially in recent years, with an alarmingly rising trend, particularly with relation to recurrent and chronic infection. The number of studies examining the relationship between an individual's glycemic status and the development of dermatophytoses, and a comparison of the evolving species trend between diabetic and non-diabetic patients infected with dermatophytes, is limited. Our aim was to study and compare the clinical and mycological aspects of dermatophytosis among diabetic and non-diabetic patients and to compare the culture isolates in both groups. This study included 378 patients of clinically suspected dermatophytosis, divided into two groups of 189 known diabetics and non-diabetics each. We subsequently analysed and compared the demographics, clinical data, potassium hydroxide (KOH) mount, calcofluor white staining, and fungal culture results of all patients in both groups. Among the 378 patients, the male: female ratio was 1.2:1. Diabetic patients had a significantly greater extent of involvement and higher rates of recurrence when compared to the non-diabetics. The overall positivity rate was higher in Calcofluor white staining (77.8%) as compared to KOH (57.7%) in both non-diabetics and diabetics. Trichophyton mentagrophytes was the most common isolate(47.6%) in both diabetic (55.0%) and non-diabetic (61.4%) patients, followed by Trichophyton rubrum (31.8% & 29.6% respectively). The overall specificity and sensitivity of the study may have been affected by the possibility that KOH mount findings might have been misinterpreted as false negatives due to cognitive bias and inter-personal observer variance. Due to purposive sampling, we were unable to analyse and compare the total prevalence of dermatophytosis in diabetics and non-diabetics. The pattern of dermatophytosis is comparatively more chronic and severe in diabetics compared to non-diabetics. Trichophyton mentagrophytes was the most common culture isolate in both the groups. There was no change in species isolate between both the groups. Calcofluor white staining can potentially be used as the initial method of choice for the diagnosis of dermatophytosis as it has significantly outperformed the conventional KOH mount.
A Wilcoxon--mann--whitney Measure of Effect Size When There Are Two Covariates
Authors: Wilcox Rand 
Published: April 2023

Abstract
A basic method for characterizing the difference between two independent groups is p, the probability that a randomly sampled value from the first group is less than a randomly sampled value from the second group. Recently, a method for making inferences about p was proposed that deals with a covariate. A goal here is to report simulation results when there are two covariates. Included is a suggestion for picking the covariate points. The method is illustrated with data dealing with depressive symptoms among older adults.
Modification of the radiation-based Abtew reference evapotranspiration model under humid climate, Northeast India
Authors: Pandey Pankaj Kumar , Pandey Vanita 
Published: April 2023

Abstract

This study aimed to improve the Abtew model for reference evapotranspiration (ET0) calculation in Northeast India using seven temperature-based solar radiation models. The temperature-based models require only air temperature as input data, which can be easily measured in most locations worldwide. The performance of the improved Abtew models (A1-A7), along with the Stephen Stewart model (SS), the Irmak model (Ir), and the modified Turc model (MT), was evaluated under the climatic conditions of Dibrugarh, Northeast India, using statistical indices such as mean absolute error (MAE), root mean square error (RMSE), standard error (SE), coefficient of correlation (r), coefficient of determination (R2), and index of agreement (D). The results showed that the seven improved Abtew models (RMSE = 0.40–0.53 mm/day; D = 0.81–0.93) outperformed the four physical models (RMSE = 0.43–2.77 mm/day; D = 0.49–0.91) for the ET0 estimate at Dibrugarh. The statistical analysis identified that the A6 model ranked highest for Dibrugarh. This study highlights the significant improvement in ET0 estimation accuracy by utilizing temperature-based solar radiation models in the Abtew model. Therefore, we strongly recommend using the A6 model to estimate ET0, which requires only temperature data as input, for estimating ET0 under the climatic conditions of Dibrugarh, Northeast India.
My Health, My Life, My Way—An Inclusive Web-Based Self-management Program for People With Disabilities Living With Chronic Conditions: Protocol for a Multiphase Optimization Strategy Study
Authors: Evans Eric , Zengul Ayse , Knight Amy , Willig Amanda , Cherrington Andrea , Mehta Tapan , Thirumalai Mohanraj 
Published: April 2023

Background
Individuals with disabilities living with chronic health conditions require self-management programs that are accessible, sustainable, inclusive, and adaptable. Health coaching is an effective approach to promoting behavior change in self-management. Health coaching combined with telehealth technology has the potential to improve the overall quality of, and access to, health services.

Objective
This protocol outlines the study design for implementing the My Health, My Life, My Way intervention. The study will assess the feasibility, acceptability, and preliminary efficacy of the intervention for people with disabilities and optimize it.

Methods
The My Health, My Life, My Way study is a 4-arm randomized controlled trial evaluating the delivery of a 6-month intervention involving telecoaching, inclusive educational content, and technology access for 200 individuals with chronic conditions and physical disabilities. This study uses the engineering-inspired multiphase optimization strategy (MOST) framework to evaluate intervention components and assess whether a combination or lack of individual elements influences behavior. Participants will be randomized to 1 of 4 study arms: scheduled coaching calls and gamified rewards, no scheduled coaching calls and gamified rewards, scheduled coaching calls and flat rewards, and no scheduled coaching calls and flat rewards.

Results
The My Health, My Life, My Way study was approved by the institutional review board of the University of Alabama at Birmingham, and recruitment and enrollment will begin in May 2023. Data analysis is expected to be completed within 6 months of ending data collection. This clinical trial protocol was developed based on the SPIRIT (Standard Protocol Items: Recommendations for Interventional Trials) 2013 statement.

Conclusions
The My Health, My Life, My Way study will help to optimize and improve our understanding of the feasibility and efficacy of a web-based self-management program for people with physical disabilities and chronic conditions. More specifically, My Health, My Life, My Way will determine which combination of interventions (coaching calls and gamification) will result in increased participation in self-management programming. The My Health, My Life, My Way intervention has the potential to become a scalable and novel method to successfully manage chronic conditions in people with disabilities.

Trial Registration
ClinicalTrials.gov NCT05481593; https://clinicaltrials.gov/ct2/show/NCT05481593

International Registered Report Identifier (IRRID)
PRR1-10.2196/31694
Practices of oral health maintenance, caries protective factors and caries experience in adults in Sekeloa Region
Authors: Susilo Fania Syakira , Aripin Dudi , Suwargiani Anne Agustina 
Published: April 2023

Introduction: Dental caries is still the most common oral disease experienced in Indonesia. Caries is caused by various factors. Practices in maintaining proper oral health are urgently needed to maintain healthy teeth and mouth to avoid various diseases, including caries. Caries prevention is inseparable from the role of protective factors that maintain the caries balance. This study was aimed at discovering the level of oral health maintenance practices, caries protective factors, as well as caries experience in adults in Sekeloa Region. Methods: The research method was descriptive cross-sectional with purposive sampling technique. The sample consisted of 61 permanent residents aged 35-44 years in South Sekeloa. Data was collected through questionnaire and DMF-T index examination. Discussion: Dental health maintenance practices including frequency, times, duration, techniques, type of brush bristles, use of brushes according to its lifetime, use of fluoride-containing toothpaste, use of interdental cleaning tools, frequency of dental visits, frequency of scaling procedures, and food consumption along with caries protective factors including the consumption of non-cariogenic snacks, xylitol chewing gum, use of chlorhexidine or fluoride mouthwash, pit and fissure sealant and topical fluoride treatments play an important role in preventing caries. Results: This study shows that subjects performed good practices of oral health maintenance (47.54%), adequate (50.82%), bad (1.64%), and good caries protective factors (1.64%), adequate (52.46%), bad (45.90%). The caries experience degree reached 9.13 and was categorized as moderate. Conclusion: The degree of caries experience in adults aged 35-44 years in the Sekeloa Region was moderate, oral health maintenance practices and caries protective factors were adequate.
Pelvic floor muscle morphology and its impact on urinary incontinence and faecal incontinence
Authors: Lazarchuk Ivanna , Barzak Bartosz , Wozniak Slawomir 
Published: April 2023

Abstract
Health problems related to pelvic floor muscles, as faecal incontinence (FI), urinary incontinence (UI) and constipation have a significant negative impact on a person’s life. The disease is accompanied by a serious symptoms, which exclude the patient from the local community. It is noteworthy that FI and UI involve increased financial outlays for the treatment of these disorders.
Definition of the faecal incontinence is an uncontrolled passage of faecal materials that has occurred at least two to four times within four weeks of the last six months.
Anatomy of pelvic fundus is strictly corelated with those diseases, because ability to contract and relax the muscles of the pelvic floor helps with the body’s daily basic functions.
Risk factors of FI/UI include age, gender, comorbidities such as diabetes and irritable bowel syndrome, and obstetric factors. It could be treated with physiotherapy, pharmacotherapy or invasive treatment.
A review of the literature indicates that the problem of FI/UI is a significant clinical issue of concern to clinicians due to very limited treatment techniques. There is a lack of primary research covering this issue in the world literature. The authors of this paper therefore believe that a holistic view of the subject based on the latest scientific data is necessary.
Cadaver preserving methods – is it possible to do anything better?
Authors: Mrożek Andrzej , Sędzik Mikołaj , Rubin Jakub , Buras Szymon , Tarkowski Victoria , Domagała Zygmunt 
Published: April 2023

Abstract
It is impossible to imagine learning anatomy without properly fixating cadavers. Thanks to accurate preservation techniques, students can differentiate anatomical structures by their sight and touch. The formalin method was first described almost 150 years ago, and as such it may seem primitive, however it is effective and easy to use, which is why it is still in use today. Despite formaldehyde’s bactericidal, fungicidal, and insecticidal properties contact with vapors of embalming solutions such as formalin may have a negative health effect. Skin drying, eczema, allergic contact dermatitis and lowered red blood cells (RBCs) and platelets are only a few symptoms that may occur as a result of spending long periods of time in places where cadavers are stored.
Due to formalin’s features, other techniques were invented. Thiel’s method is also well known; after liquid application, tissues remain their natural color as the method is non-irritating and almost odorless. With the rise of technology, more modern methods of cadaver preservation were developed as alternative to formalin, such as the use of N-vinyl-2-pyrrolidone (NVP), which is commonly implemented in Japan and Brazil, and the Modified Larssen solution (MLS), which gives the possibility to reduce formalin concentration without losing the effectiveness of tissue preservation.
The aim of this work is to develop an integrated approach to cadaver preservation through the analysis of frequently used preservation techniques. This is a considerable issue because first-year students of medicine and related faculties encounter the preserved material while learning anatomy.
In comparison to more modern methods, formalin seems to be the worst choice due to worse joint flexibility, tissue colour and structure and, most importantly, its cancerogenic action.
Human ovarian follicular granulosa cells isolated during ART procedure reflect substantial changes in activation of hormonal signaling pathways, during long-term in vitro conditions
Authors: Zgórecka Wiktoria , Blatkiewicz Małgorzata , Jankowski Maurycy , Kranc Wiesława , Bryja Artur , Brązert Maciej , Chermuła Błażej , Pieńkowski Wojciech , Pawelczyk Leszek , Mozdziak Paul 
Published: April 2023

Abstract
The ovary is commonly known as an endocrine gland responsible for sex steroid production. One of the outstanding cells in ovarian microenvironment - granulosa cells (GCs) are responsible for converting the androgens to estrogens during follicular growth and secreting progesterone after ovulation. These secretory processes within the ovary are directly involved in hormonal signaling pathways, and they depend on different stages of cholesterol and lipid biosynthesis during the ovarian cycle. The understating of the regulation and further investigation into the processes taking part in ovary will expose new clinical advantages in detection and treatment of female reproductive system diseases associated with sex hormone abnormalities. The expression of genes belonging to ontology groups associated with steroid biosynthesis and metabolism, such as “cholesterol biosynthetic process” (GO:0006695, “regulation of lipid biosynthetic process” (GO:0046890), “regulation of lipid metabolic process” (GO:0019216), “response to insulin” (GO:0032868) and “response to lipopolysaccharide” (GO:0032496) were analyzed by using the microarray approach. The patterns of gene expression in human GCs at days 1-day, 7-day, 15-day, and 30-day of primary in vitro culture have been analyzed. Based on the microarray results, a group of upregulated genes have been selected: CCL20, CXCL5, STAR, MSMO1, and AADAC. The genes STAT5B, OPA3, PPARG, PROX1, and SEC14L2 were decreased across all the experimental groups during the 30-day cell cultivation period. These results suggest that, the GCs in cell culture under in vitro express steroidogenic markers and it is important to understand associations with lipid and liposaccharide synthesis relative to reproductive medicine.
Analysis of network information security issues under the background of big data
Authors: Zhao Xuezhi , Lin Liangcheng , Guo Tao , Du Jinbao , Feng Baozhan 
Published: April 2023

Abstract
With the progress of the times, big data will follow the development of the Internet and show a broader development space. But the characteristics of big data itself also make it more difficult to solve the problems of network attacks and theft of sensitive information. Therefore, it is more important to conduct in-depth research on network information security in many fields in the context of big data. In this paper, we build a DFN-Big Data network model based on deep feed-forward network as the algorithm, and conduct an in-depth study on network information security. The calculation results show that, among several leakage methods of personal information, the leakage caused by hacking is the most dangerous and unpredictable. The percentage of cyber incidents caused by hacking is 43%. The network security problem caused by excessive collection of personal user information is also very serious, and its percentage is 34%. Establishing a sound legal regulatory system can effectively reduce the occurrence of network information leakage. Compared with other security technology solutions, a sound legal regulatory system increases network information security by 67%. Information protection technology improves network information security by 87%.
Research on power quality assessment based on ubiquitous power IoT
Authors: Zhang Min , Zhi Huiqiang , Zhao Jun , Li Rui , Chang Xiao , Fan Rui , Xu Kai 
Published: April 2023

Abstract
With the rapid development of the Internet in this era, the traditional power grid is no longer able to meet the growing demand of the people for electricity. In order to realize a new generation of power system with comprehensive sensing, reliable transmission, intelligent processing and interconnection, the State Grid proposes the strategic goal of developing ubiquitous power IoT. Firstly, the concept and basic architecture of ubiquitous power IoT are elaborated, and then the main key technologies of the architecture of power energy consumption monitoring and management system are explained. The power quality parameters are measured and calculated, and the G1 method, which is computationally small and does not require consistency testing, is used to determine the subjective weights in the power quality evaluation process, which can truly reflect the power quality level of power grids in different regions. The information entropy method is used to determine the objective weights in the process of power quality evaluation to solve the error of artificially determined weights, and the combination of subjective weights and objective weights can more truly reflect the influence of each index on the comprehensive level of power quality. The results of the study show that PV is rated between 2 and 3 good when grid-connected and off-grid, and wind turbines are rated between 3 and 4 medium when grid-connected and off-grid. The results of the integrated assessment levels are in line with the actual situation and can meet the growing demand for electricity.
Digital Finance in the Context of Common Wealth Helps Regional Economic Development of High Quality
Authors: Zhang Chenjing , Mao Di , Ma Fenfen 
Published: April 2023

Abstract
Digital transformation has pass through aspects of social livelihood and manufacture services, and digital finance has become a new motor for progress with quality as the main goal of China’s financial condition. Here first elaborates on the connotation of progress with quality as the main goal, selects 20 indicators from five aspects of progress with quality as the main goal, necessity and progression productiveness, and measures the indicator weights using principal component analysis. Secondly, spatial panel information originate 30 all regions in China are used to study the coordinated action condition among mathematical finance and the progress with quality as the main goal regional financial condition using the spatial face-plate pattern. Finally, the coordinated action test and enclosure correlation are applied to verify coordinated action mathematical financial condition progression on capital situation in different regions high-quality development and the internal system of action. The empirical results show that the capital situation in different regions progression in China exhibits 86.67% more significant spatial autocorrelation, and the Moran I index values of the mathematical financial condition progression level and progress with quality as the main goal from 2010 to 2021 are both greater than 0, and both are important at the 1% magnitude, directive that the continuous create and progression of mathematical treasury supply important positive contribution to progress with quality as the main goal economic development. The research in here provides a acknowledge basis for strengthening the construction of mathematical infrastructure, improving the capital market and related policies, and expedite the digital reform transversion finance.