bluuebunny/crossref_metadata_2025_split huggingface dataset:
Are epigenetic mechanisms and nutrition effective in male and female infertility?
Authors: Erdoğan Kadriye , Sanlier Nazlı Tunca , Sanlier Nevin 
Published: September 2023

AbstractThis review discusses epigenetic mechanisms and the relationship of infertility in men and women in relation to parameters pertaining to nutrition. The prevalence of infertility worldwide is 8–12 %, and one out of every eight couples receives medical treatment. Epigenetic mechanisms, aging, environmental factors, dietary energy and nutrients and non-nutrient compounds; more or less energy intake, and methionine come into play in the occurrence of infertility. It also interacts with vitamins B12, D and B6, biotin, choline, selenium, zinc, folic acid, resveratrol, quercetin and similar factors. To understand the molecular mechanisms regulating the expression of genes that affect infertility, the environment, the role of genotype, age, health, nutrition and changes in the individual's epigenotype must first be considered. This will pave the way for the identification of the unknown causes of infertility. Insufficient or excessive intake of energy and certain macro and micronutrients may contribute to the occurrence of infertility as well. In addition, it is reported that 5–10 % of body weight loss, moderate physical activity and nutritional interventions for improvement in insulin sensitivity contribute to the development of fertility. Processes that pertain to epigenetics carry alterations which are inherited yet not encoded via the DNA sequence. Nutrition is believed to have an impact over the epigenetic mechanisms which are effective in the pathogenesis of several diseases like infertility. Epigenetic mechanisms of individuals with infertility are different from healthy individuals. Infertility is associated with epigenetic mechanisms, nutrients, bioactive components and numerous other factors.
Ice-flow model emulator based on physics-informed deep learning
Authors: Jouvet Guillaume , Cordonnier Guillaume 
Published: September 2023

Abstract
Convolutional neural networks (CNN) trained from high-order ice-flow model realisations have proven to be outstanding emulators in terms of fidelity and computational performance. However, the dependence on an ensemble of realisations of an instructor model renders this strategy difficult to generalise to a variety of ice-flow regimes found in the nature. To overcome this issue, we adopt the approach of physics-informed deep learning, which fuses traditional numerical solutions by finite differences/elements and deep-learning approaches. Here, we train a CNN to minimise the energy associated with high-order ice-flow equations within the time iterations of a glacier evolution model. As a result, our emulator is a promising alternative to traditional solvers thanks to its high computational efficiency (especially on GPU), its high fidelity to the original model, its simplified training (without requiring any data), its capability to handle a variety of ice-flow regimes and memorise previous solutions, and its relatively simple implementation. Embedded into the ‘Instructed Glacier Model’ (IGM) framework, the potential of the emulator is illustrated with three applications including a large-scale high-resolution (2400x4000) forward glacier evolution model, an inverse modelling case for data assimilation, and an ice shelf.
Constitutionalising Israel's Constitutional System
Authors: Totry-Jubran Manal 
Published: September 2023

AbstractThe current political landscape in Israel, with countrywide demonstrations occurring weekly, and citizens calling for democracy in the face of initiatives introduced by the coalition, may be regarded as transformative events with potential constitutional implications. This article explores the question of whether Israel is experiencing a ‘constitutional moment’ and what such a moment entails, taking into account the intricate social, legal and political reality of the country. I argue that the current events should be examined and analysed within a broader context of processes that have been occurring in the Israeli society and legal system over the past two decades. These processes may hinder or create challenges for the realisation of a constitutional moment, rather than facilitating progress towards that goal. Correspondingly, the article lays the basic foundations for the occurrence of an Israeli constitutional moment, which I refer to as ‘constitutionalising Israel's constitutional system’.
Projected Changes in Mountain Precipitation Under CO2‐Induced Warmer Climate
Authors: Kad Pratik , Ha Kyung‐Ja , Lee Sun‐Seon , Chu Jung‐Eun 
Published: September 2023

AbstractMountains play a vital role in shaping regional and global climate, altering atmospheric circulation and precipitation patterns. To this end, identifying projected changes in mountain precipitation is significantly challenging due to topographic complexity. This study explains how mountain precipitation could respond to rising greenhouse gases. Using a series of century‐long fully coupled high‐resolution simulations conducted with the Community Earth System Model, we aim to disentangle future changes in mountain precipitation in response to atmospheric carbon dioxide (CO2) perturbations. Our research findings indicate that the warming observed in global mountains is more pronounced when compared to the mean warming rates experienced globally and in the ocean under elevated CO2. We identify five low‐latitude mountain ranges with elevation‐dependent precipitation response, including New Guinea, East Africa, Eastern Himalayas, Central America, and Central Andes. Those mountains are expected to have a mixture of increasing and decreasing precipitation in response to CO2‐induced warming, especially over the summit and steep topography. To elucidate the mechanisms controlling future changes in mountain precipitation, we propose “Orographic moisture omega feedback” in which an increase in low‐level relative humidity enhances local precipitation by strengthening the upward motion through moist processes for the wetting response and vice versa for the drying response. The effects of Mountain precipitation changes can be extended to hydrology and could lead to significant consequences for human societies and ecosystems.
Comment on “Unraveling the Role of IMF Bx in Driving Geomagnetic Activity” by Kubyshkina et al
Authors: Holappa Lauri , Reistad Jone Peter , Ohma Anders 
Published: September 2023

AbstractThe coupling of the interplanetary magnetic field (IMF) with the Earth's magnetic field can result in spectacular auroral displays, including substorms. An important feature of substorms is the westward electrojet that is routinely monitored by the AL index, based on ground magnetometer measurements. Recent research shows that, during periods of significant dipole tilt, the value of the AL index is strongly modulated by the dawn‐dusk (or y) component of the IMF (By): the AL index is stronger for By > 0 than By < 0 during negative dipole tilt (Northern Hemisphere winter). Kubyshkina et al. (2023, https://doi.org/10.1029/2022ja031275) argued that this By dependence of the AL index is not really caused by IMF By but by the component along the Sun‐Earth line (x axis)—namely IMF Bx, which is strongly anticorrelated with By. Here we provide strong evidence that the By dependence of the AL index is indeed much stronger than the suggested Bx dependence. In fact, the analysis of Kubyshkina et al. (2023, https://doi.org/10.1029/2022ja031275) provided similar evidence. We also note that the physical mechanism proposed by Kubyshkina et al. (2023, https://doi.org/10.1029/2022ja031275) to explain the suggested Bx dependence is contradicted by observations. However, we cannot completely rule out its existence.
Water Charge and Conservation of Natural Areas: An Ex‐Ante Assessment of a Policy Proposal for the Mantiqueira Region, Brazil
Authors: Rocha Ademir , Haddad Eduardo , Leal Alan , Corrêa João 
Published: September 2023

AbstractWater plays a central role in several socioeconomic and environmental nexuses. Faced with various anthropogenic pressures that act as water scarcity drivers and knowing that the unavailability of water can be a limiting factor for economic development, there is an urgent need for the design and evaluation of economic instruments that help in the management of water resources. This article presents a proposal and assessment for a Pigouvian water charge instrument. The instrument suggests imposing a charge based on the amount of water consumed, targeting the agriculture, livestock, forest extraction, and aquaculture sectors. The revenue generated from this charge could be utilized to fund reforestation initiatives and support government expenditures, thereby creating both environmental and economic advantages. Based on a calibrated static computable general equilibrium economic model for the Brazilian Mantiqueira region, it was possible to estimate that a water charge policy at a rate of R$ 0.10/m3 (US$ 0.026/m3) could lead to an increase in the Brazilian GDP in the benchmark year by US$ 10.7 million. Economic benefits could also be verified at the regional level, especially in those areas where there are water‐intensive economic activities. On the environmental side, the water charge could incentivize actions capable of recovering approximately 80 km2 of natural areas.
YAP1 expression is associated with survival and immunosuppression in small cell lung cancer
Authors: Chen Peixin , Sun Chenglong , Wang Hao , Zhao Wencheng , Wu Yan , Guo Haoyue , Zhou Caicun , He Yayi 
Published: September 2023

AbstractImmunotherapy is considered a major breakthrough in the treatment of small cell lung cancer (SCLC), although its anti-tumor efficacy is limited. With a high degree of malignancy and high heterogeneity, SCLC is difficult to treat in the clinic. A new combination strategy is urgently needed to further improve the efficacy of immunotherapy in patients with SCLC. By immunofluorescence, 100 SCLC patients in a local cohort were classified into the SCLC-A (high ASCL1 expression; n = 36), SCLC-N (high NEUROD1 expression; n = 32), SCLC-P (high POU2F3 expression; n = 14), and SCLC-Y (high YAP1 expression; n = 18) subtypes. Each SCLC molecular subtype represented different prognoses, tumor microenvironment traits, and immunotherapy sensitivities. Analysis of both the local and public cohorts suggested that the SCLC-Y subtype exhibited the worst clinical outcome (p < 0.05) when compared with other subtypes. SCLC with high YAP1 expression was characterized by high PD-L1 expression, high stromal score, T-cell functional impairment, and a close relationship with immune-related pathways. YAP1 upregulated PD-L1 expression and suppressed T cell activation, thus leading to immune evasion. In in vitro experiments, blockade of YAP1 promoted cancer cell apoptosis, immune cell proliferation, T-cell activation, and cytotoxic T-cell infiltration, thus further potentiating the efficacy of immunotherapy in patients with the SCLC-Y subtype.
Earthworms contribute significantly to global food production
Authors: Fonte Steven J. , Hsieh Marian , Mueller Nathaniel D. 
Published: September 2023

AbstractEarthworms are critical soil ecosystem engineers that support plant growth in numerous ways; however, their contribution to global agricultural production has not been quantified. We estimate the impacts of earthworms on global production of key crops by analyzing maps of earthworm abundance, soil properties, and crop yields together with earthworm-yield responses from the literature. Our findings indicate that earthworms contribute to roughly 6.5% of global grain (maize, rice, wheat, barley) production and 2.3% of legume production, equivalent to over 140 million metric tons annually. The earthworm contribution is especially notable in the global South, where earthworms contribute 10% of total grain production in Sub-Saharan Africa and 8% in Latin America and the Caribbean. Our findings suggest that earthworms are important drivers of global food production and that investment in agroecological policies and practices to support earthworm populations and overall soil biodiversity could contribute greatly to sustainable agricultural goals.
Natural product P57 induces hypothermia through targeting pyridoxal kinase
Authors: Wang Ruina , Xiao Lei , Pan Jianbo , Bao Guangsen , Zhu Yunmei , Zhu Di , Wang Jun , Pei Chengfeng , Ma Qinfeng , Fu Xian , Wang Ziruoyu , Zhu Mengdi , Wang Guoxiang , Gong Ling , Tong Qiuping , Jiang Min , Hu Junchi , He Miao , Wang Yun , Li Tiejun , Liang Chunmin , Li Wei , Xia Chunmei , Li Zengxia , Ma Dengke K. , Tan Minjia , Liu Jun Yan , Jiang Wei , Luo Cheng , Yu Biao , Dang Yongjun 
Published: September 2023

AbstractInduction of hypothermia during hibernation/torpor enables certain mammals to survive under extreme environmental conditions. However, pharmacological induction of hypothermia in most mammals remains a huge challenge. Here we show that a natural product P57 promptly induces hypothermia and decreases energy expenditure in mice. Mechanistically, P57 inhibits the kinase activity of pyridoxal kinase (PDXK), a key metabolic enzyme of vitamin B6 catalyzing phosphorylation of pyridoxal (PL), resulting in the accumulation of PL in hypothalamus to cause hypothermia. The hypothermia induced by P57 is significantly blunted in the mice with knockout of PDXK in the preoptic area (POA) of hypothalamus. We further found that P57 and PL have consistent effects on gene expression regulation in hypothalamus, and they may activate medial preoptic area (MPA) neurons in POA to induce hypothermia. Taken together, our findings demonstrate that P57 has a potential application in therapeutic hypothermia through regulation of vitamin B6 metabolism and PDXK serves as a previously unknown target of P57 in thermoregulation. In addition, P57 may serve as a chemical probe for exploring the neuron circuitry related to hypothermia state in mice.
1/4 is the new 1/2 when topology is intertwined with Mottness
Authors: Mai Peizhi , Zhao Jinchao , Feldman Benjamin E. , Phillips Philip W. 
Published: September 2023

AbstractIn non-interacting systems, bands from non-trivial topology emerge strictly at half-filling and exhibit either the quantum anomalous Hall or spin Hall effects. Here we show using determinantal quantum Monte Carlo and an exactly solvable strongly interacting model that these topological states now shift to quarter filling. A topological Mott insulator is the underlying cause. The peak in the spin susceptibility is consistent with a possible ferromagnetic state at T = 0. The onset of such magnetism would convert the quantum spin Hall to a quantum anomalous Hall effect. While such a symmetry-broken phase typically is accompanied by a gap, we find that the interaction strength must exceed a critical value for this to occur. Hence, we predict that topology can obtain in a gapless phase but only in the presence of interactions in dispersive bands. These results explain the recent quarter-filled quantum anomalous Hall effects seen in moiré systems.
Spatiotemporal observation of quantum crystallization of electrons
Authors: Murase Hideaki , Arai Shunto , Hasegawa Tatsuo , Miyagawa Kazuya , Kanoda Kazushi 
Published: September 2023

AbstractLiquids crystallize as they cool; however, when crystallization is avoided in some way, they supercool, maintaining their liquidity, and freezing into glass at low temperatures, as ubiquitously observed. These metastable states crystallize over time through the classical dynamics of nucleation and growth. However, it was recently found that Coulomb interacting electrons on charge-frustrated triangular lattices exhibit supercooled liquid and glass with quantum nature and they crystallize, raising fundamental issues: what features are universal to crystallization at large and specific to that of quantum systems? Here, we report our experimental challenges that address this issue through the spatiotemporal observation of electronic crystallization in an organic material. With Raman microspectroscopy, we have successfully performed real-space and real-time imaging of electronic crystallization. The results directly capture strongly temperature-dependent crystallization profiles indicating that nucleation and growth proceed at distinctive temperature-dependent rates, which is common to conventional crystallization. However, the growth rate is many orders of magnitude larger than that in the conventional case. The temperature characteristics of nucleation and growth are universal, whereas unusually fast growth kinetics features quantum crystallization where a quantum-to-classical catastrophe occurs in interacting electrons.
Establishment of a recombinase polymerase amplification detection method for Puccinia striiformis f. sp. tritici
Authors: Liu Yaoxia , Hao Jianyun , Guo Qingyun , Yan Jiahui , Yao Qiang 
Published: September 2023

AbstractWheat stripe rust caused by Puccinia striiformis f. sp. tritici (Pst) is an airborne disease that endangers wheat during its entire growth period. In this study, the Pst134EA_003354 uncharacterized protein (GenBank: XM_047941824.1) of Pst was used as the target sequence, and the primers PS-RPA-F and PS-RPA-R, as well as the probe PS-LF-probe, were designed for recombinase polymerase amplification (RPA) technology. Flow chromatography was combined with the process to establish an RPA detection method for Pst. This method successfully established visual detection within 10 min under a constant temperature of 39 °C, and the detection results were consistent with those of ordinary PCR analysis. However, it only had high specificity for Pst, and the detection limit was 10 fg/μL. In addition, this rapid method successfully detected Pst from wheat leaves during the field incubation period, indicating substantial benefits for applied use. In summary, the RPA detection method established in this study has the favourable characteristics of high efficiency, simple functionality, and rapid and universal practicability, providing a theoretical basis for the early detection and prevention of Pst.
Role of pinch in Argon impurity transport in ohmic discharges of Aditya-U Tokamak
Authors: Shah K. , Ghosh J. , Patel S. , Chowdhuri M. B. , Jadeja K. A. , Shukla G. , Macwan T. , Kumar A. , Dolui S. , Singh K. , Tanna R. L. , Patel K. M. , Dey R. , Manchanda R. , Ramaiya N. , Kumar R. , Aich S. , Yadava N. , Purohit S. , Gupta M. K. , Nagora U. C. , Pathak S. K. , Atrey P. K. , Mayya K. B. K. 
Published: September 2023

AbstractWe present experimental results of the trace argon impurity puffing in the ohmic plasmas of Aditya-U tokamak performed to study the argon transport behaviour. Argon line emissions in visible and Vacuum Ultra Violet (VUV) spectral ranges arising from the plasma edge and core respectively are measured simultaneously. During the experiments, space resolved brightness profile of Ar1+ line emissions at 472.69 nm (3p44s 2P3/2–3p44p 2D3/2), 473.59 nm (3p44s 4P5/2–3p44p 4P3/2), 476.49 nm (3p44s 2P1/2–3p44p 2P3/2), 480.60 nm (3p44s 4P5/2–3p44p 4P5/2) are recorded using a high resolution visible spectrometer. Also, a VUV spectrometer has been used to simultaneously observe Ar13+ line emission at 18.79 nm (2s22p 2P3/2–2s2p22P3/2) and Ar14+ line emission at 22.11 nm (2s21S0–2s2p 1P1). The diffusivity and convective velocity of Ar are obtained by comparing the measured radial emissivity profile of Ar1+ emission and the line intensity ratio of Ar13+ and Ar14+ ions, with those simulated using the impurity transport code, STRAHL. Argon diffusivities ~ 12 m2/s and ~ 0.3 m2/s have been observed in the edge (ρ > 0.85) and core region of the Aditya-U, respectively. The diffusivity values both in the edge and core region are found to be higher than the neo-classical values suggesting that the argon impurity transport is mainly anomalous in the Aditya-U tokamak. Also, an inward pinch of ~ 10 m/s mainly driven by Ware pinch is required to match the measured and simulated data. The measured peaked profile of Ar density suggests impurity accumulation in these discharges.
Kardar–Parisi–Zhang roughening associated with nucleation-limited steady crystal growth
Authors: Akutsu Noriko 
Published: September 2023

AbstractThe roughness of crystal surfaces and the shape of crystals play important roles in multiscale phenomena. For example, the roughness of the crystal surface affects the frictional and optical properties of materials such as ice or silica. Theoretical studies on crystal surfaces based on the symmetry principle proposed that the growing surfaces of crystal growth could be classified in the universal class of Kardar–Parisi–Zhang (KPZ), but experiments rarely observe KPZ properties. To fill this the gap, extensive numerical calculations of the crystal growth rates and the surface roughness (surface width) have been performed for a nanoscale lattice model using the Monte Carlo method. The results indicate that a (001) surface is smooth within the single nucleation growth region. In contrast, the same surface is atomically smooth but thermodynamically rough in the poly-nucleation growth region in conjunction with a KPZ roughness exponent. Inclined surfaces are known to become Berezinskii–Kosterlitz–Thouless (BKT) rough surfaces both at and near equilibrium. The two types of steps associated with the (001) and (111) terraces were found to induce KPZ surface roughness, while the interplay between steps and multilayered islands promoted BKT roughness.
The influence of energy and temperature distributions on EHD destabilization of an Oldroyd-B liquid jet
Authors: Moatimid Galal M. , Amer Mohamed F. E. 
Published: September 2023

AbstractThis work examines the impact of an unchanged longitudinal electric field and the ambient gas on the EHD instability of an Oldroyd-B fluid in a vertical cylinder, where the system is immersed in permeable media. In order to explore the possible subject uses in thermo-fluid systems, numerous experimental and theoretical types of research on the subject are conducted. The main factors influencing the dispersion and stability configurations are represented by the energy and concentration equations. The linear Boussinesq approximating framework is recommended for further convenience. A huge growth in numerous physical and technical implications is what motivated this study. Using the standard normal modes of examination, the characteristics of velocity fields, temperature, and concentration are analyzed. The conventional stability results in a non-dimensional convoluted transcendental dispersion connection between the non-dimensional growth rate and all other physical parameters. The Maranogoni phenomenon, in which temperature and concentration distributions affect surface tension, has been addressed. It is observed that the intense electric field, the Prandtl numeral, the Lewis numeral, and the Lewis numeral velocity ratio have a stabilizing influence. As opposed to the Weber numeral, the Ohnesorge numeral, and the density ratio have a destabilizing influence.