bluuebunny/crossref_metadata_2025_split huggingface dataset:
The impact of agarose immobilization on the activity of lytic Pseudomonas aeruginosa phages combined with chemicals
Authors: Dorotkiewicz-Jach Agata , Markwitz Paweł , Rachuna Jarosław , Arabski Michał , Drulis-Kawa Zuzanna 
Published: January 2023

Abstract
The implementation of non-traditional antibacterials is currently one of the most intensively explored areas of modern medical and biological sciences. One of the most promising alternative strategies to combat bacterial infections is the application of lytic phages combined with established and new antibacterials. The presented study investigates the potential of agarose-based biocomposites containing lytic Pseudomonas phages (KT28, KTN4, and LUZ19), cupric ions (Cu2+), strawberry furanone (HDMF), and gentamicin (GE) as antibacterials and anti-virulent compounds for novel wound dressings. Phages (KT28, KTN4, LUZ19, and triple-phage cocktail) alone and in combination with a triple-chemical mixture (Cu + GE + HDMF) when applied as the liquid formulation caused a significant bacterial count reduction and biofilm production inhibition of clinical P. aeruginosa strains. The immobilization in the agarose scaffold significantly impaired the bioavailability and diffusion of phage particles, depending on virion morphology and targeted receptor specificity. The antibacterial potential of chemicals was also reduced by the agarose scaffold. Moreover, the Cu + GE + HDMF mixture impaired the lytic activity of phages depending on viral particles’ susceptibility to cupric ion toxicity. Therefore, three administration types were tested and the optimal turned out to be the one separating antibacterials both physically and temporally. Taken together, the additive effect of phages combined with chemicals makes biocomposite a good solution for designing new wound dressings. Nevertheless, the phage utilization should involve an application of aqueous cocktails directly onto the wound, followed by chemicals immobilized in hydrogel dressings which allow for taking advantage of the antibacterial and anti-virulent effects of all components.

Key points
• The immobilization in the agarose impairs the bioavailability of phage particles and the Cu + GE + HDMF mixture.
• The cupric ions are toxic to phages and are sequestrated on phage particles and agarose matrix.
• The elaborated TIME-SHIFT administration effectively separates antibacterials both physically and temporally.
Do we still need to screen our patients?—Orthopaedic scoring based on motion tracking
Authors: Raab Dominik , Heitzer Falko , Liaw Jin Cheng , Müller Katharina , Weber Lina , Flores Francisco Geu , Kecskeméthy Andrés , Mayer Constantin , Jäger Marcus 
Published: January 2023

Abstract
Purpose
Orthopaedic scores are essential for the clinical assessment of movement disorders but require an experienced clinician for the manual scoring. Wearable systems are taking root in the medical field and offer a possibility for the convenient collection of motion tracking data. The purpose of this work is to demonstrate the feasibility of automated orthopaedic scorings based on motion tracking data using the Harris Hip Score and the Knee Society Score as examples.

Methods
Seventy-eight patients received a clinical examination and an instrumental gait analysis after hip or knee arthroplasty. Seven hundred forty-four gait features were extracted from each patient’s representative gait cycle. For each score, a hierarchical multiple regression analysis was conducted with a subsequent tenfold cross-validation. A data split of 70%/30% was applied for training/testing.

Results
Both scores can be reproduced with excellent coefficients of determination R2 for training, testing and cross-validation by applying regression models based on four to six features from instrumental gait analysis as well as the patient-reported parameter ‘pain’ as an offset factor.

Conclusion
Computing established orthopaedic scores based on motion tracking data yields an automated evaluation of a joint function at the hip and knee which is suitable for direct clinical interpretation. In combination with novel technologies for wearable data collection, these computations can support healthcare staff with objective and telemedical applicable scorings for a large number of patients without the need for trained clinicians.
Assessment of cataract surgery outcomes in Nampula (Mozambique): visual acuity, visual function and quality of life
Authors: Sengo Dulnério Barbosa , Saravila Pires João , Chivinde Sancho Sanuel , Mate Laura Mavota , Faquihe Momade Fumo , Moragues Raul , López-Izquierdo Inmaculada , Caballero Pablo 
Published: January 2023

Abstract
Background
Despite advances in surgical techniques, cataract remains the leading cause of preventable blindness, and massive surgeries have been adopted as a strategy to change this situation. Monitoring the results of cataract surgeries has become imperative to ensure their quality. Therefore, this study aims to assess the cataract surgery outcomes performed at the Central Hospital of Nampula Mozambique.

Methods
This is a prospective and longitudinal study in which translation, cultural adaptation and validation of the visual function (VF) and quality of life (QoL) questionnaire were performed. The appearance, content, construct, criterion, internal consistency and responsiveness were validated using the most common methods and indicators. Visual acuity (VA), VF and QoL were evaluated on 447 patients before and after surgery by t-test and effect sizes.

Results
VF and QoL questionnaires showed one-dimension, good values of TLI (0.973, 0.951) and SRMR (0.057, 0.054), and for each item, weights > 0.7, H2 > 0.5, ranges > 5.8 and the RMSEA < 0.08. Correlations for criterion validity were high and for responsiveness were high for QoL and moderate for VF one and the ordinal Cronbach’s alpha coefficients were greater than 0.97. Difference between VA, VF and QoL before and after surgery was statistically significant (p < 0.001). After surgery, 74.3% of patients had good, 23.5% had borderline and 2.2% had poor VA.

Conclusions
The cataract surgery outcomes are outside the WHO recommendations regarding VA, but they have had a great impact on improving VF and QoL. The questionnaires showed excellent psychometric properties and should be used in daily clinical practice to evaluate the results of cataract surgeries.
Working situation and burden of work limitations in sarcoma patients: results from the multi-center prospective PROSa study
Authors: Zapata Bonilla Sergio Armando , Fried Marius , Singer Susanne , Hentschel Leopold , Richter Stephan , Hohenberger Peter , Kasper Bernd , Andreou Dimosthenis , Pink Daniel , Arndt Karin , Bornhäuser Martin , Schmitt Jochen , Schuler Markus K. , Eichler Martin 
Published: January 2023

Abstract
Purpose
We investigated predictors of limitations in work performance, odds of drop out of work, and odds of receiving disability pension in sarcoma patients.

Methods
We measured clinical and sociodemographic data in adult sarcoma patients and recorded if the patients received a (1) disability pension at baseline or (2) had dropped out of work 1 year after initial assessment. (3) Work limitations were assessed using the Work-limitations questionnaire (WLQ©). We analyzed exploratively.

Results
(1) Amongst 364 analyzed patients, odds to receive a disability pension were higher in patients with abdominal tumors, older patients, high grade patients and with increasing time since diagnosis. (2) Of 356 patients employed at baseline, 21% (n = 76) had dropped out of work after 1 year. The odds of dropping out of work were higher in bone sarcoma patients and in patients who received additive radiotherapy ± systemic therapy compared with patients who received surgery alone. Odds of dropping out of work were less amongst self-employed patients and dropped with increasing time since diagnosis. (3) Work limitations were higher in woman and increased with age. Patients with bone and fibrous sarcomas were more affected than liposarcoma patients. Patients with abdominal tumors reported highest restrictions. Sarcoma treatment in the last 6 months increased work limitations.

Conclusion
Work limitations, drop out of work and dependence on a disability pension occurs frequently in patients with sarcoma adding to the burden of this condition. We were able to identify vulnerable groups in both the socioeconomic and disease categories.
Characteristics of the IGS receiver clock performance from multi-GNSS PPP solutions
Authors: Mikoś Marcin , Kazmierski Kamil , Sośnica Krzysztof 
Published: January 2023

AbstractGlobal navigation satellite system (GNSS) receivers belonging to the International GNSS Service (IGS) are equipped with different types of clocks, such as internal crystal quartz clocks, rubidium and cesium atomic clocks, as well as hydrogen masers. These clocks are characterized by different phase and frequency accuracies and stabilities, resulting in different systematic clock time series patterns. We analyze the clock offsets between different GNSS systems, provide noise characteristics of the undifferenced and differenced clock parameters, and detect systematic patterns of the clocks. The time series of the receiver clocks are dominated by the diurnal, semidiurnal, and sometimes terdiurnal signals with amplitudes up to several meters. Hydrogen masers provide the highest clock stability, and the lowest is by internal clocks. However, there are also groups of very stable internal clocks that perform similarly to low-performing hydrogen masers and rubidium clocks. The interquartile ranges for epoch-differenced clock parameters fall between 3 and 250 mm for the best hydrogen masers and the worst internal clocks, respectively.
Generalised Wendland functions for the sphere
Authors: Hubbert Simon , Jäger Janin 
Published: January 2023

AbstractIn this paper, we compute the spherical Fourier expansion coefficients for the restriction of the generalised Wendland functions fromd-dimensional Euclidean space to the (d− 1)-dimensional unit sphere. We use results from the theory of special functions to show that they can be expressed in a closed form as a multiple of a certain3F2hypergeometric function. We present tight asymptotic bounds on the decay rate of the spherical Fourier coefficients and, in the case wheredis odd, we are able to provide the precise asymptotic rate of decay. Numerical evidence suggests that this precise asymptotic rate also holds whendis even and we pose this as an open problem. Finally, we observe a close connection between the asymptotic decay rate of the spherical Fourier coefficients and that of the corresponding Euclidean Fourier transform.
The Virtuousness of Ethical Networks: How to Foster Virtuous Practices in Nonprofit Organizations
Authors: Mion Giorgio , Vigolo Vania , Bonfanti Angelo , Tessari Riccardo 
Published: January 2023

AbstractEthical networks are an emerging form of social alliance based on collaboration between organizations that share a common ethical commitment. Grounded in a theoretical framework of virtue-based business ethics and focusing on nonprofit alliances, this study investigates the virtuousness of ethical networks; that is, how they trigger virtuous practices in their member nonprofit organizations. Adopting a qualitative grounded theory approach, the study focuses on one of the largest Italian ethical networks of nonprofit organizations operating in the social care sector. The findings show that shared ethical values and religious beliefs are positively associated with ethical network building. Based on these findings, a circular model of virtuousness is proposed in which ethical networks foster virtuous practices among their members at four levels: (1) the strategic orientation level, (2) the institutional level, (3) the organizational level, and (4) the relational level. At each of these levels, ethical networks foster a habituation to virtues and the propagation of virtuous behaviors among their members. Theoretical, practical, and social implications of the research findings are discussed.
Mathematics intelligent tutoring system for learning multiplication and division of fractions based on diagnostic teaching
Authors: Shih Shu-Chuan , Chang Chih-Chia , Kuo Bor-Chen , Huang Yu-Han 
Published: January 2023

AbstractA one-on-one dialogue-based mathematics intelligent tutoring system (ITS) for learning multiplication and division of fractions was developed and evaluated in this study. This system could identify students’ error types and misconceptions in real-time by using a block-based matching method. The adaptive dialogue-based instruction was supported by a response-driven tutoring model, which was constructed based on the diagnostic teaching methodology. Instructional strategies including provoking cognitive conflict, problem simplification and representational teaching were used in the tutoring model of the system. Effectiveness of the math ITS in remedial instruction was evaluated through a quasi-experimental study. The participants of the study were 66 sixth graders chosen from central Taiwan. They were divided into an experimental group of 35 and a control group of 31. One week after the pretest, the experimental group received 2-h one-on-one instruction via the math ITS, while the control group took a 2-h conventional teacher instruction with the same teaching content in the classroom. All participants took a post-test within 2 days after the remedial instruction. The results showed that the experimental group using the math ITS significantly outperformed the control group. Further analysis indicated that the math ITS had a significant effect on the lesser-performing group (the lower 75% in the pretest score). In addition, a usability and user experience survey showed that students were willing and likely to learn mathematics using the dialogue-based math ITS.
Associations Between Parenting Stress and Quality Time in Families of Youth with Autism Spectrum Disorder
Authors: Bradley Rebecca S. , Staples Grace L. , Quetsch Lauren B. , Aloia Lindsey S. , Brown Cynthia E. , Kanne Stephen M. 
Published: January 2023

AbstractIncreased stress among parents of youth with ASD has been well-documented. However, research on aspects of the parent-child relationship and subsequent links to parenting stress is limited. We assessed parents (N = 511) of youth with ASD to examine relations between parenting stress and parent-child quality time (amount of quality time, shared enjoyment, synchronicity). Elevated parenting stress was associated with less time spent engaging with youth in shared activities and decreased parent and child enjoyment during shared interactions. Parents with elevated stress reported engaging in shared activities and experiencing synchronicity with their child less often than parents below the clinical threshold. Future research should emphasize longitudinal efforts examining the directionality of this relationship to better inform family-focused intervention.
Measuring the Readability of Geometric Proofs: The Area Method Case
Authors: Quaresma Pedro , Graziani Pierluigi 
Published: January 2023

AbstractUsing an approach, inspired by our modernisation of Lemoine’s Geometrography, this paper proposes a new readability criterion for formal proofs produced by automated theorem provers for geometry. We analyse two criteria to measure the readability of a proof: the criterion given by Chou et al. and the one given by Wiedijk. After discussing the limitations of these two criteria, we introduce a novel approach, which provides a new criterion. We conclude discussing some future work.
Calculation of the degree of crystallinity of HDPE/GNPs nanocomposites by using various experimental techniques: a comparative study
Authors: Tarani Evangelia , Arvanitidis Ioannis , Christofilos Dimitrios , Bikiaris Dimitrios N. , Chrissafis Konstantinos , Vourlias George 
Published: January 2023

AbstractThis work is a comparative study of four different techniques to determine the crystallinity of high-density polyethylene (HDPE) nanocomposites filled with different diameter sizes (5, 15 and 25 μm) of graphene nanoplatelets (GNPs) at various amounts (0.5–5 wt%). The structure of HDPE/GNPs nanocomposites was extensively studied by using different experimental methods, such as X-ray diffraction, X-ray photoelectron spectroscopy, Fourier transform infrared spectroscopy, and Raman spectroscopy. To further provide a complete comparison, differential scanning calorimetry measurements were utilized to calculate the crystallinity values, while temperature-modulated DSC was employed to investigate the possible mechanism of the different crystalline structures. It was found that these methods can be used to estimate the crystallinity, but the sample parameters and experimental conditions must be taken into consideration. All the techniques showed that the crystallinity depends on GNPs size and content. The distance between dispersed platelets was substantial at low concentrations of GNPs, making it comparatively easy for additional nucleation sites to incorporate the polymer matrix, and the crystal nucleus was simply formed. However, at high concentrations of GNPs, the diffusion of polymer chains to the growing crystallites was hindered by large GNPs particles, despite the formation of additional nucleation sites.
On von Neumann regularity of cellular automata
Authors: Salo Ville 
Published: January 2023

AbstractWe show that a cellular automaton on a one-dimensional two-sided mixing subshift of finite type is a von Neumann regular element in the semigroup of cellular automata if and only if it is split epic onto its image in the category of sofic shifts and block maps. It follows from previous joint work of the author and Törmä that von Neumann regularity is a decidable condition, and we decide it for all elementary CA, obtaining the optimal radii for weak generalized inverses. Two sufficient conditions for non-regularity are having a proper sofic image or having a point in the image with no preimage of the same period. We show that the non-regular ECA 9 and 28 cannot be proven non-regular using these methods. We also show that a random cellular automaton is non-regular with high probability.
Healthcare utilization and costs among intracranial meningioma patients during long-term follow-up
Authors: Huynh Kevin A. , Coopmans Eva C. , Zamanipoor Najafabadi Amir H. , Dirven Linda , Peerdeman Saskia M. , Biermasz Nienke R. , Verstegen Marco J. T. , van Furth Wouter R. ,   the Dutch Meningioma Consortium, Boele Florien W. , Klein Martin , Koekkoek Johan , Lagerwaard Frank , van der Meer Pim B. , Taphoorn Martin J. B. , Moojen Wouter A. , Reijneveld Jaap C. 
Published: January 2023

Abstract
Purpose
Few studies have reported on healthcare utilization and costs for intracranial meningioma patients, while the tumor and its treatment profoundly affect patients’ functioning and well-being. Here we evaluated healthcare utilization and costs, including their determinants.

Methods
A multicenter cross-sectional study of adult meningioma patients ≥ 5 years after intervention. Patients completed three validated patient-reported outcome measures (PROMs) assessing patients ‘functioning and wellbeing (SF-36, EORTC QLQ-BN20, and HADS) and a study-specific questionnaire assessing healthcare utilization over the previous twelve months. Healthcare costs of the twelve months prior were calculated using reported healthcare utilization ≥ 5 years after intervention by the Dutch Manual for Economic Evaluation in Healthcare. Determinants for healthcare utilization and costs were determined with regression analyses.

Results
We included 190 patients with WHO grade I or II meningioma after a mean follow-up since intervention of 9.2 years (SD 4.0). The general practitioner (80.5%), physiotherapist (37.9%), and neurologist (25.4%) were visited most often by patients. Median annual healthcare costs were €871 (IQR €262–€1933). Main contributors to these costs were medication (45.8% of total costs, of which anti-seizure medication was utilized most [21.6%]), specialist care (17.7%), and physiotherapy (15.5%). Lower HRQoL was a significant determinant for higher healthcare utilization and costs.

Conclusion
In patients with meningioma, medication costs constituted the largest expenditure of total healthcare costs, in particular anti-seizure medication. Particularly a lower HRQoL was a determinant for healthcare utilization and costs. A patient-specific approach aimed at improving patients’ HRQoL and needs could be beneficial in reducing disease burden and functional recovery.
Tailoring load balancing of cellular automata parallel execution to the case of a two-dimensional partitioned domain
Authors: De Rango Alessio , Giordano Andrea , Mendicino Giuseppe , Rongo Rocco , Spataro William 
Published: January 2023

AbstractIn this paper, techniques for dynamic load balancing of the cellular automata parallel execution are presented for the case of domain space partitioned along two dimensions. Starting from general closed-form expressions that allow to compute the optimal workload assignment in a dynamic fashion when partitioning takes place along only one dimension, we tailor the procedure to allow partitioning and balancing along both dimensions. Both qualitative and quantitative experiments are carried out that assess performance improvement in applying load balancing for the case of two-dimensional partitioned domain, especially when the load balancing takes place along both dimensions.
Deep learning-based semantic vessel graph extraction for intracranial aneurysm rupture risk management
Authors: Niemann Annika , Behme Daniel , Larsen Naomi , Preim Bernhard , Saalfeld Sylvia 
Published: January 2023

Abstract
Purpose
Intracranial aneurysms are vascular deformations in the brain which are complicated to treat. In clinical routines, the risk assessment of intracranial aneurysm rupture is simplified and might be unreliable, especially for patients with multiple aneurysms. Clinical research proposed more advanced analysis of intracranial aneurysm, but requires many complex preprocessing steps. Advanced tools for automatic aneurysm analysis are needed to transfer current research into clinical routine.

Methods
We propose a pipeline for intracranial aneurysm analysis using deep learning-based mesh segmentation, automatic centerline and outlet detection and automatic generation of a semantic vessel graph. We use the semantic vessel graph for morphological analysis and an automatic rupture state classification.

Results
The deep learning-based mesh segmentation can be successfully applied to aneurysm surface meshes. With the subsequent semantic graph extraction, additional morphological parameters can be extracted that take the whole vascular domain into account. The vessels near ruptured aneurysms had a slightly higher average torsion and curvature compared to vessels near unruptured aneurysms. The 3D surface models can be further employed for rupture state classification which achieves an accuracy of 83.3%.

Conclusion
The presented pipeline addresses several aspects of current research and can be used for aneurysm analysis with minimal user effort. The semantic graph representation with automatic separation of the aneurysm from the parent vessel is advantageous for morphological and hemodynamical parameter extraction and has great potential for deep learning-based rupture state classification.