bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Trojan Horse Delivery Vehicle Carrying siRNA Nanotherapeutics with Multiple Tumor Microenvironment Responsiveness Elicits Robust Antitumor Immune Responses In Situ via a “Self‐Synergistic” Approach
Authors: Fang Yan , Chen Shuai , Zhang Mingyi , Lin Xiaojie , Jin Xuechao , Zhang Mingming , Liu Yunmeng , Wang Yaxin , Shi Kai 
Published: August 2023

AbstractThe potential of small interfering RNAs (siRNAs) in the treatment of malignant tumors has attracted increasing attention due to their inherent advantages. However, their therapeutic performance strongly depends on the efficiency of their cytoplasmic delivery in vivo by the delivery vehicle with good cellular permeability and histocompatibility. Herein, a polycationic carrier camouflaged with macrophage membrane (MPM) is constructed biomimetically, which is condensed from endogenous spermine monomers through diselenide bonds. The developed Trojan horse delivery vehicle has desirable compression efficacy for siRNA oligo against PD‐L1 (siPDL1) as well as intracytoplasmic release properties derived from its sequential degradation triggered by redox microenvironment in tumor cells. Furthermore, the coloading of photosensitizer can mediate photodynamic therapy (PDT) accompanied by the generation of reactive oxygen species (ROS) upon light irradiation applied, which accelerated the degradation of the carrier as well as the release of cargoes while enhancing the PD‐L1 blockage‐mediated immunotherapy by inducing in‐situ immunogenic cell death. Moreover, the synchronously delivered siPDL1 attenuated the ROS‐induced increase in immunosuppressive PD‐L1 expression, thereby effectively eliciting a robust antitumor immune response with a “self‐synergistic” manner in the xenograft breast cancer mouse model.
A Review on Quantum Dot‐Based Color Conversion Layers for Mini/Micro‐LED Displays: Packaging, Light Management, and Pixelation
Authors: Chen Junchi , Zhao Qiliang , Yu Binhai , Lemmer Uli 
Published: August 2023

AbstractMini/microlight‐emitting diodes (LEDs) are one of the most promising technologies for next‐generation displays to meet the requirements of demanding applications, including augmented reality/virtual reality displays, wearable devices, and microprojectors. To realize full‐color displays, the strategy of combining miniaturized blue nitride‐based LEDs with color conversion layers is promising due to the high efficiencies of the LEDs and the advantageous manufacturing. Quantum dots (QDs), owing to their high photoluminescence quantum yield, small particle size, and solution processability, have emerged as the color conversion material with the most potential for mini/micro‐LEDs. However, the integration of QDs into display technologies poses several challenges. From the material side, the stability of QD materials is still challenging. For the case of packaging QDs in a matrix, the dispersion quality of QDs and the light extraction of the emission need to be improved. From the fabrication side, the lack of high‐precision mass manufacturing strategies in QD pixelation hinders the widespread application of QDs. Toward the issues above, this review summarizes the research on QD materials for color conversion display in recent years to systematically draw an overview of the packaging strategies, the light management approaches, and the pixelation methods of QD materials toward mini/micro‐LED‐based display technologies.
Determination of Free Charge Carrier Luminescence and Quasi‐Fermi Level Separation in Organic Solar Cells via Transient Photoluminescence Measurements
Authors: List Mathias , Faisst Jared , Heinz Friedemann , Würfel Uli 
Published: August 2023

AbstractThe detection of photoluminescence (PL) is extremely valuable for photovoltaic technologies as it provides direct information about the free charge carrier densities and therefore about the separation of the quasi‐Fermi levels (ΔEF). However, for organic solar cells the PL is strongly dominated by photogenerated excitons that in part decay radiatively before they form free charge carriers via dissociation at a donor/acceptor interface. For this reason, it is impossible to deduce the free charge carrier densities and ΔEF directly from the PL signal. To overcome this severe limitation, a new approach is developed that allows disentangling the luminescence of photogenerated excitons from the one of free charge carriers. Due to the large difference in respective lifetimes—for photogenerated excitons it is ≤ ns whereas for free charge carriers it is in the µs‐range—this is achieved by time‐resolved PL measurements. For highly efficient organic solar cells, it is found that ΔEF determined from these PL transients matches perfectly with the electrical voltage. Moreover, the new method also allows for the determination of ΔEF from mere absorber films without electrodes and thus paves the way for a better understanding of organic solar cells.
Solution‐Processable Ultrapure‐Blue Light‐Emitting Electrochemical Cells
Authors: Tanaka Yuki , Ito Shun‐ichiro , Liu Junfeng , Ou Hao , Tanaka Hisaaki , Pu Jiang , Ikeno Atsuhiro , Hatakeyama Takuji , Takenobu Taishi 
Published: August 2023

AbstractLight‐emitting electrochemical cells (LECs) have attracted considerable attention owing to their unique luminescence mechanisms and device structures, making them suitable for solution processing. However, these cells encounter problems related to color purity, which plays an important role in efficient and high‐resolution displays. Here, two types of solution‐processed LECs are reported that exhibit ultrapure blue emissions at 467 and 452 nm with narrow emission full‐widths at half‐maximum (FWHM) values of 21 and 30 nm, corresponding to the Commission Internationale de l'éclairage (CIE) coordinates of (0.12, 0.15) and (0.16, 0.10), respectively. These values are obtained using the multi‐resonance‐induced thermally activated delayed fluorescence (MR‐TADF) materials, namely, ν‐DABNA and DABNA‐4TBC. The suppression of structural relaxation and vibronic coupling in these MR‐TADF materials results in high‐color‐purity emissions with a small FWHM. Host‐guest‐type LECs employing these molecules as guest emitters in a spin‐coated single active layer exhibit both ultrapure blue electroluminescence (EL) and solution processability, strongly supporting their use in building a sustainable society in the future.
Screen‐Printing Technology for Scale Manufacturing of Perovskite Solar Cells
Authors: Chen Changshun , Ran Chenxin , Yao Qing , Wang Jinpei , Guo Chunyu , Gu Lei , Han Huchen , Wang Xiaobo , Chao Lingfeng , Xia Yingdong , Chen Yonghua 
Published: August 2023

AbstractAs a key contender in the field of photovoltaics, third‐generation thin‐film perovskite solar cells (PSCs) have gained significant research and investment interest due to their superior power conversion efficiency (PCE) and great potential for large‐scale production. For commercialization consideration, low‐cost and scalable fabrication is of primary importance for PSCs, and the development of the applicable film‐forming techniques that meet the above requirements plays a key role. Currently, large‐area perovskite films are mainly produced by printing techniques, such as slot‐die coating, inkjet printing, blade coating, and screen‐printing. Among these techniques, screen printing offers a high degree of functional layer compatibility, pattern design flexibility, and large‐scale ability, showing great promise. In this work, the advanced progress on applying screen‐printing technology in fabricating PSCs from technique fundamentals to practical applications is presented. The fundamentals of screen‐printing technique are introduced and the state‐of‐the‐art studies on screen‐printing different functional layers in PSCs and the control strategies to realize fully screen‐printed PSCs are summarized. Moreover, the current challenges and opportunities faced by screen‐printed perovskite devices are discussed. This work highlights the critical significance of high throughput screen‐printing technology in accelerating the commercialization course of PSCs products.
Tris‐benzo[cd]indole Cyanine Enables the NIR‐photosensitized Radical and Thiol‐ene Polymerizations at 940 nm
Authors: Elian Christine , Mourot Benjamin , Benbouziyane Camil , Malval Jean‐Pierre , Lajnef Sonia , Peyrot Fabienne , Massuyeau Florian , Siri Olivier , Jacquemin Denis , Pascal Simon , Versace Davy‐Louis 
Published: August 2023

AbstractA near‐infrared‐absorbing heptamethine (HM+) incorporating three bulky benzo[cd]indole heterocycles was designed to efficiently prevent self‐aggregation of the dye, which results in a strong enhancement of its photoinitiating reactivity as compared to a parent bis‐benzo[cd]indole heptamethine (HMCl+) used as a reference system. In this context, we highlight an efficient free‐radical NIR‐polymerization up to a 100 % acrylates C=C bonds conversion even under air conditions. Such an important initiating performance was obtained by incorporating our NIR‐sensitizer into a three‐component system leading to its self‐regeneration. This original photoredox cycle was thoroughly investigated through the identification of each intermediary species using EPR spectroscopy.
Comparison of solvent systems on extraction, quality characteristics, and volatile compounds of palm kernel oil
Authors: Asuzu Peace C. , Wyatt Victor T. , Asare‐Okai Papa Nii , Tawiah Nii Adjetey , Jones Kerby C. , Aryee Alberta N. A. 
Published: August 2023

AbstractHexane (HEX) and dichloromethane (DCM) have been used to extract oils from various sources due to their expansive solubility and low volatility that ease removal at low temperatures. However, environmental and health concerns make them undesirable solvents. The aim of this study was to evaluate the extraction efficiency and physicochemical characteristics of palm kernel oil (PKO) extracted with the addition of acetone in HEX‐acetone (1:1, vol/vol) and DCM‐acetone (1:1, vol/vol) mixtures as an alternative to DCM and HEX alone. PKO extracted with co‐solvent systems had better quality characteristics compared with single solvent extracts. The oil recovered, free fatty acid content, peroxide value and other quality characteristics, and thermal properties were within the range for PKO, and similar oils as stipulated in standards. Monounsaturated fatty acid content in PKO was up to 70% of which lauric acid was the most abundant (48%–52%). A total of 50 volatile compounds were identified by GC–MS in all the extracts including amide (1), alcohol (1), aldehydes (2), ketones (3), acids (6), esters (6) and hydrocarbons (31) with higher numbers of volatiles in the HEX extracts compared to the DCM extracts. Dodecanoic acid, hexanal, and 2‐undecanone were the most abundant acid, aldehyde, and ketone, respectively. Principal component analysis (PCA) differentiated the volatiles identified on the polar and non‐polar columns with 88.2% and 8.8%, and 67.3% and 19.6% of the variation accounted for by PC1 and PC2, respectively, with several common volatile components forming a cluster from all the solvents used.
The size, number, and distribution of nerve endings around and within the human epiglottis, focusing on tracheal intubation maneuvers
Authors: Reina Miguel Angel , Sala‐Blanch Xavier , Boezaart André P. , Tubbs Richard Shane , Pérez‐Rodríguez Francisco José , Riera‐Pérez Rita , Sanromán Junquera Margarita 
Published: August 2023

AbstractThe aim of this study was to examine the distribution of nerve endings in the mucosa, submucosa, and cartilage of the epiglottis and the vallecula area and to quantify them. The findings could inform the choice of laryngoscope blades for intubation procedures. Fourteen neck slices from seven unembalmed, cryopreserved human cadavers were analyzed. The slices were stained, and cross and longitudinal sections were obtained from each. The nerve endings and cartilage were identified. The primary metrics recorded were the number, area, and circumference of nerve endings located in the mucosa and submucosa of the pharyngeal and laryngeal sides of the epiglottis, epiglottis cartilage, and epiglottic vallecula zone. The length and thickness of the epiglottis and cartilage were also measured. The elastic cartilage of the epiglottis was primarily continuous; however, it contained several fragments. It was covered with dense collagen fibers and surrounded by adipose cells from the pharyngeal and laryngeal submucosa. Nerve endings were found within the submucosa of pharyngeal and laryngeal epiglottis and epiglottic vallecula. There were significantly more nerve endings on the posterior surface of the epiglottis than on the anterior surface. The epiglottic cartilage was twice the length of the epiglottis. The study demonstrated that the distribution of nerve endings in the epiglottis differed significantly between the posterior and anterior sides; there were considerably more in the former. The findings have implications for tracheal intubation and laryngoscope blade selection and design.
Rolling Circle Amplification/G‐Quadruplex‐Based Dual‐Signal Ratiometric Electrochemical Aptasensor for Ultrasensitive Detection of Pathogenic Bacteria
Authors: Ding Zishan , Yang Sha , Wang Jue , Zhao Zhuyang , Xu Hanqing , Chen Zhiguo , Liu Zhiyong , Wang Yunxia , Bao Jing , Chang Kai , Chen Ming 
Published: August 2023

AbstractAccurate and efficient detection of pathogenic bacteria plays a crucial role in the diagnosis of infectious diseases. However, rapid and highly sensitive detection of specific bacteria in clinical samples remains challenging. In this study, we developed a ratiometric dual‐signal electrochemical biosensor for ultrasensitive detection of pathogenic bacteria, based on an aptamer recognition‐induced rolling circle amplification (RCA)/G‐quadruplex strategy. On the surface of a gold electrode chip, we used an aptamer sequence (P1) conjugated to ferrocene (Fc) to capture the target bacterium. This capture released a different, previously bound sequence (P2) sequence that initiated the RCA/G‐quadruplex cascade, which, in the presence of potassium ions, was able to bind the electrochemical indicator methylene blue (MB). We integrated the signals from the loss of Fc and the appearance of MB (IMB/IFC ratio) to quantify the target bacteria concentration. This biosensor showed excellent detection performance and specificity, with a detection limit of 10 CFU/mL. Notably, it showed great diagnostic potential for clinical infectious diseases caused by pathogenic bacteria in precise/personalized medicine applications.
Co‐precipitation of NCM 811 Using Recycled and Purified Manganese: Effect of Impurities on the Battery Cell Performance
Authors: Kauppinen Toni , Laine Petteri , Välikangas Juho , Tynjälä Pekka , Hu Tao , Salminen Justin , Lassi Ulla 
Published: August 2023

AbstractCo‐precipitation of NCM811 precursors and cathodes for lithium‐ion batteries was carried out using recycled and purified manganese solution. In this paper, the aim is to study the role of the impurities in the co‐precipitation step of NMC811 and further in the battery cell performance. Based on the results, cationic impurities (Ca, Zn, Mg, and Fe) are co‐precipitated in the NMC811 precursors, as expected based on the thermodynamic considerations. The presence of these impurities was confirmed by several characterizations. Impurities did not affect the particle morphology or tap density of NMC811. Impurities had surprisingly minor effect on the cell performance. During the cycling, these cells provided good cyclability and high‐capacity retention after 1100 cycles compared to reference samples.
Ca2V2O7 as an Anode‐Active Material for Lithium‐Ion Batteries: Effect of Conductive Additive and Mass Loading on Electrochemical Performance
Authors: Silvano Leticia Trezecik , Sandherr Jens , Valadares Folgueras Marilena , Ferreira de Souza Eder Carlos , Kaya Pinar , Knoblauch Volker 
Published: August 2023

AbstractLithium‐ion batteries (LIBs) play a crucial role in using renewable sources. Vanadates have been applied as anode material due to the combined diffusion mechanisms and higher and stable capacities. Despite the interest in vanadates as anode materials, only a few studies have considered Ca2V2O7 (CVO) as an active material for LIBs. This work focuses on the use of CVO as a potential alternative anode‐active material for LIBs. Additionally, we investigate the effect of the conductive additive (C65) on the electrochemical properties of the electrodes, utilizing densified electrodes with a porosity of about 40 %. In doing so, this study provides important insights into new materials for LIBs, where the electrodes were manufactured using the commercial slurry methodology, replacing graphite by CVO – which was synthesized via the Pechini route (D50: 8 μm after milling). In summary, the results reveal that the amount of C65 positively affects the electrode‘s capacity. An increase in specific capacity was observed by up to 30 % using 10 wt.% C65. Such electrodes showed 235 mAh/gAM at C/10 and, when cycled at 1 C, completed 300 cycles with a retained capacity of 39 %. The results demonstrate that CVO might be a promising anode material for LIB energy storage systems.
Bilateral tone mapping scheme for color correction and contrast adjustment in nearly invisible medical images
Authors: Subramani Bharath , Veluchamy Magudeeswaran 
Published: August 2023

AbstractMedical images are commonly used to diagnose and screen various diseases. However, medical images taken by operators with different skill levels have a considerable variation in visual quality. Poor illumination of images increases uncertainty in clinical treatment and lead to the risk of misdiagnosis. This paper proposes a novel bilateral tone‐mapped gamma correction to enhance the visual quality of medical images without affecting the natural color quality. First, the proposed tone‐mapped gamma correction is employed to enhance the intensity values of poorly illuminated medical images. Then, bilateral enhancement curve adjustment is performed to effectively improve the global luminance content of the input image with features and richer information. The image quality assessment measures like entropy, blind/reference less image spatial quality evaluator, natural image quality evaluator, perception‐based image quality evaluator, contrast enhancement based image quality parameter, and color contrast fog density evaluates the superior performance of the proposed technique. The experimental results significantly enhance the intensity difference between dark and bright areas and can aid clinical experts and intelligent health fields.
Stay Hydrated! Impact of Solvation Phenomena on the CO2 Reduction Reaction at Pb(100) and Ag(100) surfaces
Authors: Cheong Oskar , Bornhake Thomas , Zhu Xinwei , Eikerling Michael H. 
Published: August 2023

AbstractHerein, a comprehensive computational study of the impact of solvation on the reduction reaction of CO2 to formic acid (HCOOH) and carbon monoxide on Pb(100) and Ag(100) surfaces is presented. Results further the understanding of how solvation phenomena influence the adsorption energies of reaction intermediates. We applied an explicit solvation scheme harnessing a combined density functional theory (DFT)/microkinetic modeling approach for the CO2 reduction reaction. This approach reveals high selectivities for CO formation at Ag and HCOOH formation on Pb, resolving the prior disparity between ab initio calculations and experimental observations. Furthermore, the detailed analysis of adsorption energies of relevant reaction intermediates shows that the total number of hydrogen bonds formed by HCOO plays a primary role for the adsorption strength of intermediates and the electrocatalytic activity. Results emphasize the importance of explicit solvation for adsorption and electrochemical reaction phenomena on metal surfaces.
Intensive therapy can improve long‐term survival in newly diagnosed, advanced‐stage extranodal NK/T‐cell lymphoma: A multi‐institutional, real‐world study
Authors: Wei Yu‐Ce , Qi Fei , Zheng Bao‐Min , Zhang Chang‐Gong , Xie Yan , Chen Bo , Liu Wei‐Xin , Liu Wei‐Ping , Fang Hui , Qi Shu‐Nan , Zhang Di , Chai Yue , Li Ye‐Xiong , Wang Wei‐Hu , Song Yu‐Qin , Zhu Jun , Dong Mei 
Published: August 2023

AbstractThe study investigated the treatment and prognosis of advanced‐stage extranodal natural killer/T‐cell lymphoma (ENKTL). With a median follow‐up of 75.03 months, the median overall survival (mOS) for the 195 newly diagnosed stage III/IV ENKTL patients was 19.43 months, and estimated 1‐, 2‐, 3‐ and 5‐year OS were 59.5%, 46.3%, 41.8% and 35.1%, respectively. Chemotherapy (CT) + radiotherapy (RT) compared to CT alone (P = .007), and hematopoietic stem cell transplantation (HSCT) compared to non‐HSCT (P < .001), both improved OS. For patients ≤60 years and ineligible for HSCT, other therapies with complete remission led to comparable OS (P = .141). Nine patients ever treated with chidamide achieved a median progression‐free survival (mPFS) and mOS of 53.63 (range, 3.47‐92.33) and 54.80 (range, 5.50‐95.70) months, and four with chidamide maintenance therapy (MT) achieved a mPFS and mOS of 55.83 (range, 53.27‐92.33) and 60.65 (range, 53.70‐95.70) months, possibly providing an alternative option for non‐HSCT patients. Non‐anthracycline (ANT)‐ compared to ANT‐, asparaginase (Aspa)‐ compared to non‐Aspa‐ and gemcitabine (Gem)‐ compared to non‐Gem‐based regimens, prolonged PFS (P = .031; P = .005; P = .009) and OS (P = .010; P = .086; P = .003), respectively. Multivariate analysis demonstrated that Gem‐based regimens improved PFS (HR = 0.691, P = .061) and OS (HR = 0.624, P = .037). Gem + Aspa combinations slightly improved PFS and OS compared to regimens containing Gem or Aspa alone (P > 0.05). First‐line “intensive therapy,” including CT (particularly Gem + Aspa regimens), RT, HSCT and alternative chidamide MT, was proposed and could improve long‐term survival for advanced‐stage ENKTLs. Ongoing prospective clinical studies may shed further light on the value of chidamide MT.
Inside Cover
Authors: Zhu Yirui , Zhao Yanzhi , Shi Jiulin , Gomez Alvarez‐arenas Tomas E. , Yang Hongwei , Cai Hongling , Zhang Dong , He Xingdao , Wu Xiaoshan 
Published: August 2023

A novel ARF‐OCE system based on a ultrasmall ultrasound transducer is presented for in vivo rabbit corneal biomechanics evaluation. This is the smallest ultrasound transducer reported in the literature for nondestructive mechanical excitation of cornea. The biomechanics of healthy corneas, keratoconus, and CXL procedures were evaluated, and the results demonstrate that ARF‐OCE can evaluate the effects of different surgical protocols on corneal biomechanics. This suggests that proposed ARF‐OCE has good clinical translation potential.For further details please visit the article by Yirui Zhu, Yanzhi Zhao, Jiulin Shi, Tomas E. Gomez Alvarez‐arenas, Hongwei Yang, Hongling Cai, Dong Zhang, Xingdao He, and Xiaoshan Wu (e202300074).
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