bluuebunny/crossref_metadata_2025_split huggingface dataset:
Halolactonization of N-Acyl-N-(2-cyclohex-1-en-1-yl-6-methylphenyl)glycines: Towards Production of 4,1-Benzoxazoheterocycles
Authors: Gataullin Rail R. 
Published: March 2023

AbstractA significant influence of the nature of the acyl substituent at the nitrogen atom on the direction of the reaction in the interaction of N-acyl-N-(2-cyclohex-1-en-1-yl-6-methylphenyl)glycines with bromine was found. In the case of the N-benzoyl derivative, along with benzoxazocinone, which is formed through the stages of pseudoallyl halogenation and subsequent lactonization due to the replacement of the bromine atom by the oxygen atom of the carboxyl group, a mixture of axially chiral isomers of spiro-fused 2′-bromocyclohexane-benzoxazepin-3-ones was also obtained. The aR*,R*,R*-isomer of benzoxazepinone, which initially is four times predominant in the reaction mixture, upon dissolution in deuterochloroform, slowly transforms into aS*-conformer until a ratio of 2:1 is established. In the case of the N-acetyl analogue of this glycine, the only heterocycle is the product of 7-exo-halogenlactonization, the benzoxazepinone spiro-fused with 2′-bromocyclohexane and an undetermined configuration of the axial chirality.
Full-dimensional quantum mechanical study of three-body recombination for cold 4He–4He–20Ne system
Authors: Zhao Ming-Ming , Wang Bin-Bin , Wang Gao-Ren , Fu Bina , Shundalau Maksim , Han Yong-Chang 
Published: March 2023

The increase of the number of the two-body recombination channels strongly challenges the numerical calculation of the accurate rates for the three-body recombination (TBR) process and its reverse process, collision-induced dissociation (CID), at ultracold temperatures. By taking the 4He–4He–20Ne collision system as an example, we have obtained the rates for its TBR and CID processes involving all four recombination channels, including the two-body states 4He2 (l = 0) and 4He20Ne (l = 0, 1, 2) with l the rotational quantum number. By using the adiabatic hyperspherical method, we have considered not only total angular momentum J = 0 but also J &gt; 0 in the ultracold collision energies (E = 0.01 − 100 mK × kB). It is found that 4He2 (l = 0) is the major product after the TBR process in the ultracold limit (E ≤ 0.1 mK × kB). The TBR rate into 4He2 (l = 0) is nearly one order of magnitude larger than the sum of the other three products, 4He20Ne (l = 0, 1, 2). Moreover, the CID rates for the three 4He20Ne (l = 0, 1, 2) + 4He initial states are close to each other and are smaller than that for the 4He2 (l = 0) + 20Ne initial state. Additionally, we have, for the first time, performed the channel-resolved scattering calculation that can explain the above-mentioned findings quantitatively.
Superstructured NiMoO
4
@CoMoO
4
core-shell nanofibers for supercapacitors with ultrahigh areal capacitance
Authors: Chang Liang , Chen Shaoqin , Fei Yuhuan , Stacchiola Dario J. , Hu Yun Hang 
Published: March 2023

High areal capacitance for a practical supercapacitor electrode requires both large mass loading and high utilization efficiency of electroactive materials, which presents a great challenge. Herein, we demonstrated the unprecedented synthesis of superstructured NiMoO
4
@CoMoO
4
core-shell nanofiber arrays (NFAs) on a Mo-transition-layer-modified nickel foam (NF) current collector as a new material, achieving the synergistic combination of highly conductive CoMoO
4
and electrochemical active NiMoO
4
. Moreover, this superstructured material exhibited a large gravimetric capacitance of 1,282.2 F/g in 2 M KOH with a mass loading of 7.8 mg/cm
2
, leading to an ultrahigh areal capacitance of 10.0 F/cm
2
that is larger than any reported values of CoMoO
4
and NiMoO
4
electrodes. This work provides a strategic insight for rational design of electrodes with high areal capacitances for supercapacitors.
In situ FRET-based localization of the N terminus of myosin binding protein-C in heart muscle cells
Authors: Chandler Jessica , Treacy Conor , Ameer-Beg Simon , Ehler Elisabeth , Irving Malcolm , Kampourakis Thomas 
Published: March 2023

Cardiac myosin binding protein-C (cMyBP-C) is a thick filament–associated regulatory protein frequently found mutated in patients suffering from hypertrophic cardiomyopathy (HCM). Recent in vitro experiments have highlighted the functional significance of its N-terminal region (NcMyBP-C) for heart muscle contraction, reporting regulatory interactions with both thick and thin filaments. To better understand the interactions of cMyBP-C in its native sarcomere environment, in situ Foerster resonance energy transfer–fluorescence lifetime imaging (FRET–FLIM) assays were developed to determine the spatial relationship between the NcMyBP-C and the thick and thin filaments in isolated neonatal rat cardiomyocytes (NRCs). In vitro studies showed that ligation of genetically encoded fluorophores to NcMyBP-C had no or little effect on its binding to thick and thin filament proteins. Using this assay, FRET between mTFP conjugated to NcMyBP-C and Phalloidin-iFluor 514 labeling the actin filaments in NRCs was detected by time-domain FLIM. The measured FRET efficiencies were intermediate between those observed when the donor was attached to the cardiac myosin regulatory light chain in the thick filaments and troponin T in the thin filaments. These results are consistent with the coexistence of multiple conformations of cMyBP-C, some with their N-terminal domains binding to the thin filament and others binding to the thick filament, supporting the hypothesis that the dynamic interchange between these conformations mediates interfilament signaling in the regulation of contractility. Moreover, stimulation of NRCs with β-adrenergic agonists reduces FRET between NcMyBP-C and actin-bound Phalloidin, suggesting that cMyBP-C phosphorylation reduces its interaction with the thin filament.
Gate-tunable transport in van der Waals topological insulator Bi4Br4 nanobelts
Authors: Wu Si-Li , Ren Zhi-Hui , Zhang Yu-Qi , Li Yong-Kai , Han Jun-Feng , Duan Jun-Xi , Wang Zhi-Wei , Li Cai-Zhen , Yao Yu-Gui 
Published: March 2023

Abstract
Bi4Br4 is a quasi-one-dimensional van der Waals topological insulator with novel electronic properties. Several efforts have been devoted to the understanding of its bulk form, yet it remains a challenge to explore the transport properties in low-dimensional structures due to the difficulty of device fabrication. Here we report for the first time a gate-tunable transport in exfoliated Bi4Br4 nanobelts. Notable two-frequency Shubnikov–de Haas oscillations oscillations are discovered at low temperatures, with the low- and high-frequency parts coming from the three-dimensional bulk state and the two-dimensional surface state, respectively. In addition, ambipolar field effect is realized with a longitudinal resistance peak and a sign reverse in the Hall coefficient. Our successful measurements of quantum oscillations and realization of gate-tunable transport lay a foundation for further investigation of novel topological properties and room-temperature quantum spin Hall states in Bi4Br4.
A rotating machinery fault feature extraction approach based on an adaptive wavelet denoising method and synthetic detection index
Authors: Zhou Tingxin , Zhang Guangtao , Lu Na , Yuan Wenlin , Guo Chaoyu , Zhang Jiaming 
Published: March 2023

Abstract
Feature extraction from vibration signals plays a vital role in rotating machinery fault diagnosis. The noise contained in the signals will interfere with the fault feature extraction result. Wavelet denoising (WD) is a commonly used method to reduce the noise, but its parameters are generally selected based on subjective experience. With this problem in mind, an adaptive wavelet denoising (AWD) method is proposed in this paper. Using permutation entropy to evaluate the signal noise level and taking its minimum value as the fitness function, the whale optimization algorithm is applied to optimize the WD parameters. Based on the AWD method and a synthetic detection index, a new feature extraction approach is proposed. Results from simulation experiments and engineering applications prove that the signal denoising performance of the AWD method and the fault feature extraction approach are satisfactory.
Coherence controlled generation of Gaussian quantum discord in a quantum beat laser
Authors: Qureshi Haleema Sadia , Ullah Shakir , Ghafoor Fazal 
Published: March 2023

Abstract
Quantum discord, an appropriate measure of quantum correlation, is analyzed in a two-mode Gaussian state of the cavity field evolved by a system of quantum beat laser. In the laser system, two arbitrary single-mode Gaussian states of the cavity fields and an external classical field couple to the atomic lasing medium. We calculate the time-dependent expression for the quantum discord both analytically and numerically, by following the reduced density matrix equation of the resulting cavity field. In this framework, we investigate the generation and control of Gaussian quantum discord in the two-mode Gaussian state of the cavity field at the output in terms of the purity and non-classicality of the two input cavity modes, the Rabi frequency of the classical driving field, the relative phase of the coupling parameters, and the damping rates of the cavity modes. The behaviour of quantum discord appears oscillatory due to the quantum beats in the output cavity field developed by the classical driving field in the medium as time passes. Moreover, we find that quantum discord switches on and off while adjusting the relative phase of the coupling parameters. Analysis of the analytical results agrees well with our numerical simulations.
A Census of Archival X-Ray Spectra for Modeling Tidal Disruption Events
Authors: Goldtooth Aaron , Zabludoff Ann I , Wen Sixiang , Jonker Peter G. , Stone Nicholas C. , Cao Zheng 
Published: March 2023

Abstract
Tidal disruption events (TDEs) are highly energetic phenomena that occur when a star is tidally disrupted by the central massive black hole in a galaxy. Fitting the observed X-ray spectra of TDEs with a first-principles, general-relativistic slim-disk model for the emission from the inner accretion disk can constrain the black hole mass M
• and dimensionless spin a
•. Multiepoch spectra can break degeneracies in parameter estimation, particularly when they include a period of super-Eddington mass accretion. Even one observed super-Eddington epoch can be useful. Constraints on {M
•, a
•} improve as a power law with the number of spectral counts; the power-law index is higher for a higher mass accretion rate. These results are supported by the successful modeling of real spectra in the nearby (0.0206 ≤ z ≤ 0.145) TDEs ASASSN-14li, 3XMM J150052.0+015452, and 3XMM J215022.4–055108, which were observed over multiple epochs with >1 ks exposure times. Guided by these results, we create an updated and expanded TDE catalog from the Open TDE compilation. We then explore the XMM-Newton and Chandra archives to identify 37 TDE candidates with promising spectra for constraining {M
•, a
•} with slim-disk model fits. At least seven TDEs are likely associated with intermediate-mass black holes. Three of the 24 TDEs with multiepoch UV/optical photometry from Swift have late-time observations that allow their light curves to be compared directly to model predictions from the X-ray spectral fits. Existing X-ray spectra for other TDEs can be augmented with future optical/UV data. Ultimately, our new TDE catalog will reveal the {M
•, a
•} distributions traced by TDEs, thereby discriminating among black hole growth scenarios and providing insights on general relativity and dark matter particle candidates. The new TDE catalog is here: https://github.com/aarongoldtooth/Census-of-TDE-and-Archival-X-Ray-UV-Data/blob/main/Full%20New%20TDE%20Catalog%20(Published).tsv, and the codes used to construct it are here: https://github.com/aarongoldtooth/Census-of-TDE-and-Archival-X-Ray-UV-Data.
Survival in a nanoforest of absorbing pillars
Authors: Grebenkov Denis S , Skvortsov Alexei T 
Published: March 2023

Abstract
We investigate the survival probability of a particle diffusing between two parallel reflecting planes toward a periodic array of absorbing pillars. We approximate the periodic cell of this system by a cylindrical tube containing a single pillar. Using a mode matching method, we obtain an exact solution of the modified Helmholtz equation in this domain that determines the Laplace transform of the survival probability and the associated distribution of first-passage times (FPTs). This solution reveals the respective roles of several geometric parameters: the height and radius of the pillar, the inter-pillar distance, and the distance between confining planes. This model allows us to explore different asymptotic regimes in the probability density of the FPT. In the practically relevant case of a large distance between confining planes, we argue that the mean FPT is much larger than the typical time and thus uninformative. We also illustrate the failure of the capacitance approximation for the principal eigenvalue of the Laplace operator. Some practical implications and future perspectives are discussed.
Enlightening the temperature coefficient of triple mesoscopic CH3NH3PbI3−x
Cl
x
/NiO and double mesoscopic CsFAMAPbI3−x
Br
x
/CuSCN carbon perovskite solar cells
Authors: Bhandari Shubhranshu , Mallick Tapas Kumar , Sundaram Senthilarasu 
Published: March 2023

Abstract
Temperature is one of the most crucial outdoor variables that influence the photovoltaic performance and stability of carbon perovskite solar cells (CPSCs), although not many reports are there on temperature-dependent CPSCs performance based on various mesoscopic structures. This study demonstrates the temperature coefficient (T
C) of carbon-based triple and double mesoscopic devices having MAPICL [MAPbI3−x
Cl
x
] and CSFAMA [Cs0.05(FA0.83MA0.17)0.95Pb(I0.83Br0.17)3] to understand the performance compatibility of different CPSC configurations despite the thermal treatment (MA = methylammonium, FA = formamidinium). While treating a single device in the range of 5 °C–65 °C, MAPICL-based CPSC maintained a power conversion efficiency (PCE) of ∼9%–11.7%. In contrast, CSFAMA-based double mesoscopic devices showed a PCE variation of ∼14%–16% in the same temperature window. The interesting fact of this analysis is that the average T
C values for MAPICL and CSFAMA are in the order of 10−4, implying better retention of performance for both mesoscopic devices despite thermal stress. A photoluminescence analysis has been done to understand the temperature-dependent charge transfer properties between the perovskite and transport layer. To the best of our knowledge, this analysis, for the first time, provides insight into the temperature coefficient of different CPSC mesoscopic structures to promote suitable future development.
Predation by the Introduced Brown Widow Spider (Araneae: Theridiidae) May Explain Local Extinctions of Native Black Widows in Urban Habitats
Authors: Coticchio Louis A , Vetter Richard , Cassill Deby L 
Published: March 2023

Abstract
Invertebrates that successfully colonize new habitats often share life history characteristics including high fertility, rapid development, and early maturation. Since its introduction into Florida, USA, the non-native Brown Widow, Latrodectus geometricus (Kock 1841, Araneae: Theridiidae), has rapidly expanded its range into urban areas as far north as Kansas and as far west as California. During its expansion, the Brown Widow has displaced Florida’s Southern Black Widow, L. mactans (Fabricius 1775, Araneae: Tjerodoodae) and California’s Western Black Widow, L. Hesperus (Chamber lin & Ivie 1935, Araneae: Theridiidae). Here, based on a field survey and controlled laboratory experiments, we report possible causes for the rapid disappearance of Florida’s Southern Black Widows. Our field survey revealed that Brown Widows have twice the fertility potential as Southern Black Widows. In experiments comparing development, we show that sub-adult Brown Widows grew faster and matured earlier relative to Southern Black Widows. In our experiments on cohabitation with neighbors, bold Brown Widows were six times more likely to kill and consume shy Southern Black Widows than bold cobweb spiders and three times more likely to cohabitate with bold cobweb spiders than with shy Southern Black Widows. Our model of maternal risk-management revealed that competition for scarce prey was not a significant cause of offspring mortality for Latrodectus species. Hence, Brown Widows are not predating Black Widows or other cobweb spiders because prey is scarce. To our knowledge, this study is the first to suggest that aggressive predation by Brown Widows is a significant factor contributing to the local extinction of the shy Southern Black Widow in urban structures.
Non-linear consensus dynamics on temporal hypergraphs with random noisy higher-order interactions
Authors: Shang Yilun 
Published: March 2023

AbstractComplex networks encoding the topological architecture of real-world complex systems have recently been undergoing a fundamental transition beyond pairwise interactions described by dyadic connections among nodes. Higher-order structures such as hypergraphs and simplicial complexes have been utilized to model group interactions for varied networked systems from brain, society, to biological and physical systems. In this article, we investigate the consensus dynamics over temporal hypergraphs featuring non-linear modulating functions, time-dependent topology and random perturbations. Based upon analytical tools in matrix, hypergraph, stochastic process and real analysis, we establish the sufficient conditions for all nodes in the network to reach consensus in the sense of almost sure convergence and $\mathscr{L}^2$ convergence. The rate of consensus and the moments of the equilibrium have been determined. Our results offer a theoretical foundation for the recent series of numerical studies and physical observations in the multi-body non-linear dynamical systems.
Technical success in performing esophageal high-resolution manometry: a review of competency recommendations, predictors of failure, and alternative techniques
Authors: Cohen Daniel L , Shirin Haim 
Published: March 2023

Abstract
Esophageal high-resolution manometry (HRM) is the gold standard for diagnosing esophageal motility disorders. As this is performed without sedation, it may be poorly tolerated by patients. Additionally, advancing the catheter tip until the stomach may also be difficult, especially if there is a disease affecting the esophagus or esophagogastric junction which may lead to coiling of the catheter. Currently, there are no guidelines as to who can perform HRM. An expert opinion has recommended minimum numbers of cases for the operator to perform in order to obtain and maintain competency. Several studies have reported on the rates of flawed HRM studies with approximately 20% being imperfect, including about 3% with critical flaws. The presence of a large hiatal hernia and achalasia have been identified as predictors of technical failure. Studies with minor flaws are usually still interpretable and clinically useful. Reports have also described several techniques for sedation-assisted placement of the HRM catheter, and this appears to be a promising alternative in cases of failed HRM, especially as sedation does not appear to significantly affect HRM measurements. An algorithm on how to proceed after a technically imperfect HRM study is proposed. Further research in this field is warranted including confirmation of the recommended competency numbers, assessing for quality measures in performing HRM such as technical success rate, identifying additional predictors of technical failure, standardization of the terminology, and qualifying the benefit of sedation-assisted HRM.
A Systematic Review on Long-Term Efficacy Outcome Measures in Crohn’s Disease Patients
Authors: Janssen Laura M , Creemers Rob H , van Bodegraven Adriaan A , Pierik Marie J 
Published: March 2023

Abstract

Background
The traditional long-term treatment goal of Crohn’s disease [CD] is maintenance of corticosteroid-free clinical remission. Additional treatment targets, such as biochemical, endoscopic and patient-reported remission, are advocated. The relapsing–remitting nature of CD provides a challenge to the timing of target assessment. Cross-sectional assessment at predetermined moments disregards the health state in between measurements. In this systematic review, we provide an overview of outcomes used to assess long-term efficacy in clinical trials in CD.

Methods
A systematic search of the PubMed and EMBASE databases was performed to identify clinical trials in luminal CD reporting on maintenance treatment [strategies] since 1995. Two independent reviewers selected eligible articles for full text retrieval, and assessed if long-term corticosteroid-free clinical, biochemical, endoscopic or patient-reported efficacy outcomes were used.

Results
The search resulted in 2452 hits and 82 articles were included. Clinical activity was used in 80 studies [98%] as the long-term efficacy outcome, and in 21 [26%] of these concomitant corticosteroid use was taken into account. C-reactive protein was used in 32 studies [41%], faecal calprotectin in 15 studies [18%], endoscopic activity in 34 studies [41%] and patient-reported outcome in 32 studies [39%]. In seven studies, clinical, biochemical, endoscopic activity and the patient’s perspective were measured. In most studies cross-sectional measures or multiple measurements over time were used.

Conclusion
In none of the published clinical trials in CD was sustained remission on all treatment targets reported. Cross-sectional outcomes at predetermined times were widely applied, leading to lack of information regarding sustained corticosteroid-free remission for this relapsing–remitting chronic disease.
MADS-box protein AGL8 interacts with chromatin-remodelling component SWC4 to activate thermotolerance and environment-dependent immunity in pepper
Authors: Zhang Yapeng , Cai Weiwei , Wang Aiwen , Huang Xueying , Zheng Xiang , Liu Qian , Cheng Xingge , Wan Meiyun , Lv Jingang , Guan Deyi , Yang Sheng , He Shuilin 
Published: March 2023

AbstractPepper (Capsicum annuum) employs distinct defence responses against Ralstonia solanacearum infection (RSI); however, the mechanisms by which pepper activates these defence responses in a context-dependent manner is unclear. Here we study pepper plants defence response to RSI under room temperature-high humidity (RSRT, 28 °C / 90%) and high temperature-high humidity (RSHT, 37 °C / 90%) conditions, and non-infected plants under high temperature-high humidity (HTHH, 42 °C / 90%) stress. Herein, we found that the MADS-box transcription factor CaAGL8 was up-regulated by HTHH stress and RSRT or RSHT, and its silencing significantly reduced pepper thermotolerance and susceptibility to infection under both room and high temperature-high humidity (RSRT and RSHT). This was coupled with down-regulation of CaSTH2 and CaDEF1 upon RSRT, down-regulation of CaMgst3 and CaPRP1 upon RSHT, and down-regulation of CaHSP24 upon HTHH. In contrast, the ectopic overexpression of CaAGL8 significantly increased the resistance of Nicotiana benthamiana plants to RSRT, RSHT, and HTHH. In addition, CaAGL8 was found to interact with CaSWC4, which acted as a positive regulator of the pepper response to RSRT, RSHT, and HTHH. Silencing of either CaAGL8 or CaSWC4 blocked the hypersensitive response (HR) cell death and context-dependent up-regulation of defence-related genes triggered by the other. Importantly, enrichment of H4K5Ac, H3K9Ac, H3K4me3, and H3K9me2 on the tested defence-related genes was context- and gene-specifically regulated through synergistic interaction between CaSWC4 and CaAGL8. Our results indicate that pepper employs CaAGL8 to modulate chromatin remodelling by interacting with CaSWC4, thereby activating defence responses to RSRT, RSHT, and HTHH.