bluuebunny/crossref_metadata_2025_split huggingface dataset:
Validation of complementary non-invasive tools for stress assessment in spotted paca (Cuniculus paca)
Authors: Altino Vanessa S , Rezende Darília CB , Nogueira Selene SC , Aldrigui Letícia G , Roldan Mar , Duarte José MB , Fureix Carole , Mendl Michael , Nogueira-Filho Sérgio LG 
Published: August 2023

Abstract
Monitoring the concentration of glucocorticoid metabolites (GCMs) in faecal samples is a non-invasive tool for physiological stress evaluation, particularly useful when studying wild species. However, both negative and positive stimuli (distress and eustress, respectively) can lead to a rise in glucocorticoids. Thus, besides validating whether GCM concentration in faeces reflects endogenous adrenal activity, we also need to identify behavioural indicators of distress to avoid misinterpretation. Therefore, we submitted four adult male spotted pacas (Cuniculus paca) to an exogenous adrenocorticotropic hormone (ACTH) challenge-test in a Latin square design (4 × 4) to monitor changes in the GCM concentration in faeces. We also aimed to describe behaviours potentially indicative of distress. We collected excreted faeces and video-recorded the animals’ behaviours for five consecutive days, one day before and four days after application of the following four treatments: 1st control (no-handling); 2nd control (intra-muscular [IM] injection of saline solution); low-dose ACTH (IM injection of 0.18 ml ACTH); and high-dose ACTH (IM injection of 0.37 ml ACTH). There was a peak in the concentration of GCM in faeces collected 24 h after the injection of the high-dose ACTH treatment. Additionally, independent of the treatments, spotted pacas spent less time on exploration and feeding states, while spending more time in the inactive but awake (IBA) state following the treatment application (challenge day). The use of GCM concentration in faecal samples together with the behavioural changes (less exploration and feeding, and more IBA) showed to be efficient as a non-invasive tool for welfare assessment of farmed spotted paca.
The aromatic bicomplex for the description of divergence-free aromatic forms and volume-preserving integrators
Authors: Laurent Adrien , McLachlan Robert I. , Munthe-Kaas Hans Z. , Verdier Olivier 
Published: August 2023

AbstractAromatic B-series were introduced as an extension of standard Butcher-series for the study of volume-preserving integrators. It was proven with their help that the only volume-preserving B-series method is the exact flow of the differential equation. The question was raised whether there exists a volume-preserving integrator that can be expanded as an aromatic B-series. In this work, we introduce a new algebraic tool, called the aromatic bicomplex, similar to the variational bicomplex in variational calculus. We prove the exactness of this bicomplex and use it to describe explicitly the key object in the study of volume-preserving integrators: the aromatic forms of vanishing divergence. The analysis provides us with a handful of new tools to study aromatic B-series, gives insights on the process of integration by parts of trees, and allows to describe explicitly the aromatic B-series of a volume-preserving integrator. In particular, we conclude that an aromatic Runge–Kutta method cannot preserve volume.
Gendered familialism in a Mediterranean context: women’s labor market participation and early childhood education and care in Turkey
Authors: Akkan Başak , Buğra Ayşe , Knijn Trudie 
Published: August 2023

AbstractThis article explores the relationship between women’s labor market participation and early childhood education and care (ECEC) in Turkey within a broader Mediterranean context. Since the 1990s, there have been significant changes in the familialist models in the Mediterranean region driven by women’s increased labor market participation and the expansion of ECEC services. The transformations in the region have unveiled a significant link between the expansion of preschool education and an increase in women’s labor market participation. Turkey missed this critical juncture in the 1990s, as indicated by the low employment rates of women and below-the-Organisation for Economic Co-operation and Development (OECD)-average preschool enrolment. Through a comparative perspective that examines the slow progress in both areas in Turkey as well as the gendered feature of its familialist model, the article emphasizes the need for closer analysis of the link between ECEC and the low labor force participation of women. Given that the expansion of ECEC in the 2000s has taken place through market-driven services, the article concludes that the link between ECEC and women’s labor market participation exhibits a class dimension. Thereby, women from lower socio-economic groups are increasingly experiencing the impact of the gendered characteristics inherent in the familialist regime in Turkey.
The Making of J. S. Mill'sCollected Works, and Its Aftermath
Authors: Kinzer Bruce 
Published: August 2023

AbstractIn 1973, a conference was held in Toronto to mark the bicentenary of James Mill's birth and the centenary of John Stuart Mill's death. By that time, Toronto had emerged as the centre of Mill studies. Between 1963 and 1973, the University of Toronto Press had published, in a scholarly edition, eleven volumes of Mill'sCollected works. A further twenty-two volumes would appear in the eighteen years that followed. Only two of the nine presenters at the 1973 conference were members of a Philosophy Department. Philosophers had a modest part in the production of Mill'sCollected works. Yet, philosophers came to dominate Mill studies in the decades after the Mill edition wrapped up in 1991. Philosophers contributed ten of the fourteen essays featured inThe Cambridge companion to Mill(1998), edited by John Skorupski. Philosophers constituted twenty-six of the thirty-seven contributors toA companion to Mill(2017), published by Wiley Blackwell and edited by Christopher Macleod and Dale E. Miller. This communication explains the relative unimportance of philosophers in the creation of theCollected works, and comments on the forces shaping the subsequent pre-eminence of philosophers in Mill studies.
Patient and citizen participation at the organizational level in health technology assessment: an exploratory study in five jurisdictions
Authors: Nabarette Hervé , Chastenay Marie-Hélène , Dupont Jean-Claude K. , Ganache Isabelle , Single Ann N.V. 
Published: August 2023

Abstract

Objective
While patient participation in individual health technology assessments (HTAs) has been frequently described in the literature, patient and citizen participation at the organizational level is less described and may be less understood and practiced in HTA bodies. We aimed to better understand its use by describing current practice.

Method
To elicit descriptive case studies and insights we conducted semi-structured interviews and open-ended questionnaires with HTA body staff and patients and citizens participating at the organizational level in Belgium, France, Quebec, Scotland, and Wales.

Results
We identified examples of organizational participation in managerial aspects: governance, defining patient involvement processes, evaluation processes and methods, and capacity building. Mechanisms included consultation, collaboration, and membership of standing (permanent) groups. These were sometimes combined. Participants were usually from umbrella patient organizations and patient associations, as well as individual patients and citizens.

Discussion
Although the concept, participation at the organizational level, is not well-established, we observed a trend toward growth in each jurisdiction. Some goals were shared for this participation, but HTA bodies focused more on instrumental goals, especially improving participation in HTAs, while patients and citizens were more likely to offer democratic and developmental goals beyond improving participation processes.

Conclusion
Our findings provide rationales for organizational-level participation from the perspectives of HTA bodies and patients. The case studies provide insights into how to involve participants and who may be seen as legitimate participants. These findings may be useful to HTA bodies, the patient sector, and communities when devising an organizational-level participation framework.
Friendly Visiting Programs for Older People Experiencing Social Isolation: A Realist Review of what Works, for whom, and under what Conditions
Authors: Weldrick Rachel , Dunn James R. , Andrews Gavin J. , Ploeg Jenny 
Published: August 2023

AbstractMany social interventions have been developed with the hopes of reducing and preventing social isolation among older people (e.g., recreation, arts-based programs and social prescription). Friendly visiting programs, also known as befriending schemes, have been a mainstay in this area for decades and are largely thought to be effective at reconnecting older people (≥ 60 years of age) experiencing isolation. Research and evaluations have yet to determine, however, how and why these programs may be most successful, and under what conditions. This article presents the findings of a realist synthesis aimed at identifying the critical mechanisms and contextual factors that lead to successful outcomes in friendly visiting programs. Seven studies are synthesized to inform a friendly visiting program theory accounting for key mechanisms (e.g., provision of informal support) and underlying contexts (e.g., training of volunteers) that can be used to inform future programs. Recommendations for future research are also presented.
Constraints on the Cryohydrological Warming of Firn and Ice in Greenland From Rayleigh Wave Ellipticity Data
Authors: Jones G. A. , Ferreira A. M. G. , Kulessa B. , Schimmel M. , Berbellini A. , Morelli A. 
Published: August 2023

AbstractRayleigh wave ellipticity measurements from seismic ambient noise recorded on the Greenland Ice Sheet (GrIS) show complex and anomalous behavior at wave periods sensitive to ice (T < 3–4 s). To understand these complex observations, we compare them with synthetic ellipticity measurements obtained from synthetic ambient noise computed for various seismic velocity and attenuation models, including surface wave overtone effects. We find that in dry snow conditions within the interior of the GrIS, to first order the anomalous ellipticity observations can be explained by ice models associated with the accumulation and densification of snow into firn. We also show that the distribution of ellipticity measurements is strongly sensitive to seismic attenuation and the thermal structure of the ice. Our results suggest that Rayleigh wave ellipticity is well suited for monitoring changes in firn properties and thermal composition of the Greenland and Antarctic ice sheets in a changing climate.
High‐Resolution Interseismic Strain Mapping From InSAR Phase‐Gradient Stacking: Application to the North Anatolian Fault With Implications for the Non‐Uniform Strain Distribution Related to Coseismic Slip Distribution
Authors: Liu Ziming , Wang Teng 
Published: August 2023

AbstractHigh‐resolution interseismic strain mapping is important for studying faulting behavior and for assessing seismic hazards. Interferometric Synthetic Aperture Radar has been widely applied to measure interseismic deformation along active strike‐slip faults. However, phase unwrapping errors and over‐smoothing effects limit its ability to map the extremely‐high strain due to shallow creep. Here, without the involvement of ground‐based measurement, we perform phase‐gradient stacking on wrapped Sentinel‐1 interferograms to directly map the shear strain rates along the North Anatolian Fault (NAF) with unprecedented resolution. The derived high‐resolution strain‐rate map reveals five strain‐concentrated segments on the NAF, implying shallow creeps. We find that their spatial distribution coincides with the lower coseismic slip of previous earthquakes that occurred since 1939. The proposed method can be applied to other less‐studied strike‐slip faults to distinguish segments with shallow creep and strong coupling, and thus to better quantify the shallow strain budget and its associated seismic hazards.
Observation of an Electron Microburst With an Inverse Time‐Of‐Flight Energy Dispersion
Authors: Shumko M. , Miyoshi Y. , Blum L. W. , Halford A. J. , Breneman A. W. , Johnson A. T. , Sample J. G. , Klumpar D. M. , Spence H. E. 
Published: August 2023

AbstractInteractions between whistler mode chorus waves and electrons are a dominant mechanism for particle acceleration and loss in the outer radiation belt. One form of this loss is electron microburst precipitation: a sub‐second intense burst of electrons. Despite previous investigations, details regarding the microburst‐chorus scattering mechanism—such as dominant resonance harmonic—are largely unconstrained. One way to observationally probe this is via the time‐of‐flight energy dispersion. If a single cyclotron resonance is dominant, then higher energy electrons will resonate at higher magnetic latitudes: sometimes resulting in an inverse time‐of‐flight dispersion with lower‐energy electrons leading. Here we present a clear example of this phenomena, observed by a FIREBIRD‐II CubeSat on 27 August 2015, that shows good agreement with the Miyoshi‐Saito time‐of‐flight model. When constrained by this observation, the Miyoshi‐Saito model predicts that a relatively narrowband chorus wave with a ∼0.2 of the equatorial electron gyrofrequency scattered the microburst.
Tunable optical topological transitions of plasmon polaritons in WTe2 van der Waals films
Authors: Xie Yuangang , Wang Chong , Fei Fucong , Li Yuqi , Xing Qiaoxia , Huang Shenyang , Lei Yuchen , Zhang Jiasheng , Mu Lei , Dai Yaomin , Song Fengqi , Yan Hugen 
Published: August 2023

AbstractNaturally existing in-plane hyperbolic polaritons and the associated optical topological transitions, which avoid the nano-structuring to achieve hyperbolicity, can outperform their counterparts in artificial metasurfaces. Such plasmon polaritons are rare, but experimentally revealed recently in WTe2 van der Waals thin films. Different from phonon polaritons, hyperbolic plasmon polaritons originate from the interplay of free carrier Drude response and interband transitions, which promise good intrinsic tunability. However, tunable in-plane hyperbolic plasmon polariton and its optical topological transition of the isofrequency contours to the elliptic topology in a natural material have not been realized. Here we demonstrate the tuning of the optical topological transition through Mo doping and temperature. The optical topological transition energy is tuned over a wide range, with frequencies ranging from 429 cm−1 (23.3 microns) for pure WTe2 to 270 cm−1 (37.0 microns) at the 50% Mo-doping level at 10 K. Moreover, the temperature-induced blueshift of the optical topological transition energy is also revealed, enabling active and reversible tuning. Surprisingly, the localized surface plasmon resonance in skew ribbons shows unusual polarization dependence, accurately manifesting its topology, which renders a reliable means to track the topology with far-field techniques. Our results open an avenue for reconfigurable photonic devices capable of plasmon polariton steering, such as canaling, focusing, and routing, and pave the way for low-symmetry plasmonic nanophotonics based on anisotropic natural materials.
Immunotherapy responsiveness and risk of relapse in Down syndrome regression disorder
Authors: Santoro Jonathan D. , Spinazzi Noemi A. , Filipink Robyn A. , Hayati-Rezvan Panteha , Kammeyer Ryan , Patel Lina , Sannar Elise A. , Dwyer Luke , Banerjee Abhik K. , Khoshnood Mellad , Jafarpour Saba , Boyd Natalie K. , Partridge Rebecca , Gombolay Grace Y. , Christy Alison L. , Real de Asua Diego , del Carmen Ortega Maria , Manning Melanie A. , Van Mater Heather , Worley Gordan , Franklin Cathy , Stanley Maria A. , Brown Ruth , Capone George T. , Quinn Eileen A. , Rafii Michael S. 
Published: August 2023

AbstractDown syndrome regression disorder (DSRD) is a clinical symptom cluster consisting of neuropsychiatric regression without an identifiable cause. This study evaluated the clinical effectiveness of IVIg and evaluated clinical characteristics associated with relapse after therapy discontinuation. A prospective, multi-center, non-randomized, observational study was performed. Patients met criteria for DSRD and were treated with IVIg. All patients underwent a standardized wean-off therapy after 9–12 months of treatment. Baseline, on-therapy, and relapse scores of the Neuropsychiatric Inventory Total Score (NPITS), Clinical Global Impression-Severity (CGI-S), and the Bush–Francis Catatonia Rating Scale (BFCRS) were used to track clinical symptoms. Eighty-two individuals were enrolled in this study. Patients had lower BFCRS (MD: −6.68; 95% CI: −8.23, −5.14), CGI-S (MD: −1.27; 95% CI: −1.73, −0.81), and NPITS scores (MD: −6.50; 95% CI: −7.53, −5.47) while they were on therapy compared to baseline. Approximately 46% of the patients (n = 38) experienced neurologic relapse with wean of IVIg. Patients with neurologic relapse were more likely to have any abnormal neurodiagnostic study (χ2 = 11.82, P = 0.001), abnormal MRI (χ2 = 7.78, P = 0.005), and abnormal LP (χ2 = 5.45, P = 0.02), and a personal history of autoimmunity (OR: 6.11, P < 0.001) compared to patients without relapse. IVIg was highly effective in the treatment of DSRD. Individuals with a history of personal autoimmunity or neurodiagnostic abnormalities were more likely to relapse following weaning of immunotherapy, indicating the potential for, a chronic autoimmune etiology in some cases of DSRD.
Lymph node targeted multi-epitope subunit vaccine promotes effective immunity to EBV in HLA-expressing mice
Authors: Dasari Vijayendra , McNeil Lisa K. , Beckett Kirrilee , Solomon Matthew , Ambalathingal George , Thuy T. Le , Panikkar Archana , Smith Caitlyn , Steinbuck Martin P. , Jakubowski Aniela , Seenappa Lochana M. , Palmer Erica , Zhang Jeff , Haqq Christopher M. , DeMuth Peter C. , Khanna Rajiv 
Published: August 2023

AbstractThe recent emergence of a causal link between Epstein-Barr virus (EBV) and multiple sclerosis has generated considerable interest in the development of an effective vaccine against EBV. Here we describe a vaccine formulation based on a lymph node targeting Amphiphile vaccine adjuvant, Amphiphile-CpG, admixed with EBV gp350 glycoprotein and an engineered EBV polyepitope protein that includes 20 CD8+ T cell epitopes from EBV latent and lytic antigens. Potent gp350-specific IgG responses are induced in mice with titers >100,000 in Amphiphile-CpG vaccinated mice. Immunization including Amphiphile-CpG also induces high frequencies of polyfunctional gp350-specific CD4+ T cells and EBV-specific CD8+ T cells that are 2-fold greater than soluble CpG and are maintained for >7 months post immunization. This combination of broad humoral and cellular immunity against multiple viral determinants is likely to provide better protection against primary infection and control of latently infected B cells leading to protection against the development of EBV-associated diseases.
Cryo-EM structures of Uba7 reveal the molecular basis for ISG15 activation and E1-E2 thioester transfer
Authors: Afsar Mohammad , Liu GuanQun , Jia Lijia , Ruben Eliza A. , Nayak Digant , Sayyad Zuberwasim , Bury Priscila dos Santos , Cano Kristin E. , Nayak Anindita , Zhao Xiang Ru , Shukla Ankita , Sung Patrick , Wasmuth Elizabeth V. , Gack Michaela U. , Olsen Shaun K. 
Published: August 2023

AbstractISG15 plays a crucial role in the innate immune response and has been well-studied due to its antiviral activity and regulation of signal transduction, apoptosis, and autophagy. ISG15 is a ubiquitin-like protein that is activated by an E1 enzyme (Uba7) and transferred to a cognate E2 enzyme (UBE2L6) to form a UBE2L6-ISG15 intermediate that functions with E3 ligases that catalyze conjugation of ISG15 to target proteins. Despite its biological importance, the molecular basis by which Uba7 catalyzes ISG15 activation and transfer to UBE2L6 is unknown as there is no available structure of Uba7. Here, we present cryo-EM structures of human Uba7 in complex with UBE2L6, ISG15 adenylate, and ISG15 thioester intermediate that are poised for catalysis of Uba7-UBE2L6-ISG15 thioester transfer. Our structures reveal a unique overall architecture of the complex compared to structures from the ubiquitin conjugation pathway, particularly with respect to the location of ISG15 thioester intermediate. Our structures also illuminate the molecular basis for Uba7 activities and for its exquisite specificity for ISG15 and UBE2L6. Altogether, our structural, biochemical, and human cell-based data provide significant insights into the functions of Uba7, UBE2L6, and ISG15 in cells.
Multi-proxy evidence for sea level fall at the onset of the Eocene-Oligocene transition
Authors: De Lira Mota Marcelo A. , Dunkley Jones Tom , Sulaiman Nursufiah , Edgar Kirsty M. , Yamaguchi Tatsuhiko , Leng Melanie J. , Adloff Markus , Greene Sarah E. , Norris Richard , Warren Bridget , Duffy Grace , Farrant Jennifer , Murayama Masafumi , Hall Jonathan , Bendle James 
Published: August 2023

AbstractContinental-scale expansion of the East Antarctic Ice Sheet during the Eocene-Oligocene Transition (EOT) is one of the largest non-linear events in Earth’s climate history. Declining atmospheric carbon dioxide concentrations and orbital variability triggered glacial expansion and strong feedbacks in the climate system. Prominent among these feedbacks was the repartitioning of biogeochemical cycles between the continental shelves and the deep ocean with falling sea level. Here we present multiple proxies from a shallow shelf location that identify a marked regression and an elevated flux of continental-derived organic matter at the earliest stage of the EOT, a time of deep ocean carbonate dissolution and the extinction of oligotrophic phytoplankton groups. We link these observations using an Earth System model, whereby this first regression delivers a pulse of organic carbon to the oceans that could drive the observed patterns of deep ocean dissolution and acts as a transient negative feedback to climate cooling.
Genomic dissection of endemic carbapenem resistance reveals metallo-beta-lactamase dissemination through clonal, plasmid and integron transfer
Authors: Macesic Nenad , Hawkey Jane , Vezina Ben , Wisniewski Jessica A. , Cottingham Hugh , Blakeway Luke V. , Harshegyi Taylor , Pragastis Katherine , Badoordeen Gnei Zweena , Dennison Amanda , Spelman Denis W. , Jenney Adam W. J. , Peleg Anton Y. 
Published: August 2023

AbstractInfections caused by metallo-beta-lactamase-producing organisms (MBLs) are a global health threat. Our understanding of transmission dynamics and how MBLs establish endemicity remains limited. We analysed two decades of blaIMP-4 evolution in a hospital using sequence data from 270 clinical and environmental isolates (including 169 completed genomes) and identified the blaIMP-4 gene across 7 Gram-negative genera, 68 bacterial strains and 7 distinct plasmid types. We showed how an initial multi-species outbreak of conserved IncC plasmids (95 genomes across 37 strains) allowed endemicity to be established through the ability of blaIMP-4 to disseminate in successful strain-genetic setting pairs we termed propagators, in particular Serratia marcescens and Enterobacter hormaechei. From this reservoir, blaIMP-4 persisted through diversification of genetic settings that resulted from transfer of blaIMP-4 plasmids between bacterial hosts and of the integron carrying blaIMP-4 between plasmids. Our findings provide a framework for understanding endemicity and spread of MBLs and may have broader applicability to other carbapenemase-producing organisms.