bluuebunny/crossref_metadata_2025_split huggingface dataset:
Carbon–Carbon Linked Organic Frameworks: An Explicit Summary and Analysis
Authors: Nath Satyapriya , Puthukkudi Adithyan , Mohapatra Jeebanjyoti , Bommakanti Suresh , Chandrasekhar Naisa , Biswal Bishnu P. 
Published: January 2023

AbstractOrganic frameworks with carbon–carbon (CC) linkage are an important class of materials owing to their outstanding chemical stability and extended π‐electron delocalization resulting in unique optoelectronic properties. In the first part of this review article, the design principles for the bottom‐up synthesis of 2D and 3D sp/sp2 CC linked organic frameworks are summarized. Representative reaction methodologies, such as Knoevenagel condensation, Aldol condensation, Horner–Wadsworth–Emmons reaction, Wittig reaction, and coupling reactions (Ullmann, Suzuki, Heck, Yamamoto, etc.) are included. This is discussed in the context of their reaction mechanism, reaction dynamics, and whether and why resulting in an amorphous or crystalline product. This is followed by a discussion of different state‐of‐the art bottom‐up synthesis methodologies, like solvothermal, interfacial, and solid‐state synthesis. In the second part, the structure–property relationships in CC linked organic frameworks with representative examples of organocatalysis, photo(electro)catalysis, energy storage and conversion, magnetism, and molecular storage and separation are analyzed. The importance of linkage type, building blocks, topology, and crystallinity of the framework material in connection with the structure–property relationship is highlighted. Finally, brief concluding remarks are presented based on the key development of bottom‐up synthetic methods and provide perspectives for future development in this field.
Loss of CRY2 promotes regenerative myogenesis by enhancing PAX7 expression and satellite cell proliferation
Authors: Hao Yingxue , Xue Ting , Liu Song‐Bai , Geng Sha , Shi Xinghong , Qian Panting , He Wei , Zheng Jiqing , Li Yanfang , Lou Jing , Shi Tianze , Wang Ge , Wang Xiaoxiao , Wang Yanli , Li Yangxin , Song Yao‐Hua 
Published: January 2023

AbstractThe regenerative capacity of skeletal muscle is dependent on satellite cells. The circadian clock regulates the maintenance and function of satellite cells. Cryptochrome 2 (CRY2) is a critical component of the circadian clock, and its role in skeletal muscle regeneration remains controversial. Using the skeletal muscle lineage and satellite cell‐specific CRY2 knockout mice (CRY2scko), we show that the deletion of CRY2 enhances muscle regeneration. Single myofiber analysis revealed that deletion of CRY2 stimulates the proliferation of myoblasts. The differentiation potential of myoblasts was enhanced by the loss of CRY2 evidenced by increased expression of myosin heavy chain (MyHC) and myotube formation inCRY2−/−cells versusCRY2+/+cells. Immunostaining revealed that the number of mononucleated paired box protein 7 (PAX7+) cells associated with myotubes formed byCRY2−/−cells was increased compared withCRY2+/+cells, suggesting that more reserve cells were produced in the absence of CRY2. Loss of CRY2 leads to the activation of the ERK1/2 signaling pathway and ETS1, which binds to the promoter of PAX7 to induce its transcription. CRY2 deficient myoblasts survived better in ischemic muscle. Therefore, CRY2 is essential in regulating skeletal muscle repair.
Design of micro‐ and macro‐scale polymeric metamaterial solutions for passive and active thermal camouflaging applications
Authors: Pisavadia Harshil , Asad Asad , Sameoto Dan , Dolez Patricia , Hogan James D. 
Published: January 2023

AbstractThis work utilizes predictive modeling techniques to guide and inform metamaterial design for heat management solutions and thermal radiation control. Specifically, micro‐ and macro‐scale polyethylene‐based solutions are proposed for passive and active thermal camouflage. A micro‐scale post design is proposed for highly‐tunable infrared emissivity based on varying unit cell geometrical configurations. Actively modulating these micro‐features through lateral straining of up to 3% allows for redshifting the emissivity spectrum by up to 0.5 µm. Macro‐scale lenticular lens designs allow for a more passive form of camouflage due to its emissive stability for a range of configurations (e.g., single and sandwiched structures, increasing lens radii and height). Overall, the proposed metamaterial designs allow the tailoring of optical properties to improve thermal radiating performance.
Predictors and significance of rapid response to behaviorally based treatment of binge eating disorder
Authors: Yurkow Sydney , Ivezaj Valentina , Grilo Carlos M. 
Published: January 2023

AbstractObjectiveThis study examined baseline predictors of rapid response and its prognostic significance in a clinical trial of behaviorally based weight loss treatment (BBWLT) for binge eating disorder in patients with obesity.MethodsOne hundred ninety‐one participants receiving BBWLT were assessed at baseline, throughout treatment, and at posttreatment (6 months) by independent assessors. Rapid response was defined as ≥ 65% reduction in binge eating by the fourth treatment week. Patients with versus without rapid response were compared on demographic features, a broad range of current/past clinical and psychiatric variables, and treatment attitudes. Rapid response was used to prospectively predict posttreatment outcomes.ResultsRapid response, which characterized 63% (N = 120) of participants, was not associated significantly with any demographic features or with any current/past clinical and psychiatric variables. Higher ratings (at week one) regarding the logic of BBWLT and greater confidence that treatment would help with binge eating and weight loss were associated significantly with rapid response (at week four). Rapid response was prospectively associated with significantly better binge eating and weight loss outcomes.ConclusionsThese findings indicate that rapid response to BBWLT for binge eating disorder prospectively predicts superior clinical outcomes in both binge eating and weight loss. Treatment attitudes, rather than patient demographic or clinical severity variables, are prospectively associated with rapid response.
Advances in the clinical management of high‐risk Wilms tumors
Authors: Ortiz Michael V. , Koenig Christa , Armstrong Amy E. , Brok Jesper , de Camargo Beatriz , Mavinkurve‐Groothuis Annelies M. C. , Herrera Thelma B. Velasquez , Venkatramani Rajkumar , Woods Andrew D. , Dome Jeffrey S. , Spreafico Filippo 
Published: January 2023

AbstractOutcomes are excellent for the majority of patients with Wilms tumors (WT). However, there remain WT subgroups for which the survival rate is approximately 50% or lower. Acknowledging that the composition of this high‐risk group has changed over time reflecting improvements in therapy, we introduce the authors’ view of the historical and current approach to the classification and treatment of high‐risk WT. For this review, we consider high‐risk WT to include patients with newly diagnosed metastatic blastemal‐type or diffuse anaplastic histology, those who relapse after having been initially treated with three or more different chemotherapeutics, or those who relapse more than once. In certain low‐ or low middle‐income settings, socio‐economic factors expand the definition of what constitutes a high‐risk WT. As conventional therapies are inadequate to cure the majority of high‐risk WT patients, advancement of laboratory and early‐phase clinical investigations to identify active agents is urgently needed.
The identification of conserved sequence features of co‐translationally decayed mRNAs and upstream open reading frames in angiosperm transcriptomes
Authors: Guo Rong , Yu Xiang , Gregory Brian D. 
Published: January 2023

AbstractRNA turnover is essential in maintaining messenger RNA (mRNA) homeostasis during various developmental stages and stress responses. Co‐translational mRNA decay (CTRD), a process in which mRNAs are degraded while still associated with translating ribosomes, has recently been discovered to function in yeast and three angiosperm transcriptomes. However, it is still unclear how prevalent CTRD across the plant lineage. Moreover, the sequence features of co‐translationally decayed mRNAs have not been well‐studied. Here, utilizing a collection of publicly available degradome sequencing datasets for another seven angiosperm transcriptomes, we have confirmed that CTRD is functioning in at least 10 angiosperms and likely throughout the plant lineage. Additionally, we have identified sequence features shared by the co‐translationally decayed mRNAs in these species, implying a possible conserved triggering mechanism for this pathway. Given that degradome sequencing datasets can also be used to identify actively translating upstream open reading frames (uORFs), which are quite understudied in plants, we have identified numerous actively translating uORFs in the same 10 angiosperms. These findings reveal that actively translating uORFs are prevalent in plant transcriptomes, some of which are conserved across this lineage. We have also observed conserved sequence features in the regions flanking these uORFs' stop codons that might contribute to ribosome stalling at these sequences. Finally, we discovered that there were very few overlaps between the mRNAs harboring actively translating uORFs and those sorted into the co‐translational decay pathway in the majority of the studied angiosperms, suggesting that these two processes might be nearly mutually exclusive in those species. In total, our findings provide the identification of CTRD and actively translating uORFs across a broad collection of plants and provide novel insights into the important sequence features associated with these collections of mRNAs and regulatory elements, respectively.
A rare case of right heart failure with the necessity for veno‐arterial extracorporeal membrane oxygenation following pulmonary vein stenosis after radiofrequency ablation for atrial fibrillation
Authors: Kopp Sabrina , Tilch Marie‐Kristin , Sagoschen Ingo , Kaes Joachim , Kuniss Malte , Neumann Thomas , Yang Yang , Schnitzler Katharina , Schmidt Kai‐Helge , Rostock Thomas , Münzel Thomas , Konstantinides Stavros , Wild Johannes , Hobohm Lukas 
Published: January 2023

AbstractPulmonary vein stenosis (PVS) after radiofrequency energy‐mediated percutaneous pulmonary vein isolation as a treatment option for atrial fibrillation is a serious complication and the prevalence in historical reports varies between 0% and 42%. Symptoms of PVS are nonspecific and can include general symptoms such as dyspnea, cough, recurrent pneumonia, and chest pain. Pathophysiologically it increases the postcapillary pressure in the pulmonary circuit and may result in pulmonary hypertension (PH). Misdiagnosis and delayed treatment are common. We here report a case of a 59‐year‐old female with a history of pulmonary vein ablation followed by progressive dyspnea (New York Heart Association IV), right heart failure, CPR, and the need for extracorporeal membrane oxygenation (ECMO). Further treatment strategy includes pulmonary vein dilatation and stenting of both the left superior pulmonary vein and left inferior pulmonary vein, as well as balloon dilatation of RIPV under temporary ECMO support. Symptomatic, severe PVS is a rare complication after catheter ablation of atrial fibrillation. PVS can result in life‐threatening complications such as PH with acute right heart failure. Early diagnosis is crucial but challenging. Mechanical cardiopulmonary support by veno‐arterial ECMO for bridging to angioplasty could be a lifesaving option.
Is there a better way of representing stationary wave functions than basis expansion?
Authors: Tao Yu , Li Yunzhi , Li Chen 
Published: January 2023

AbstractWe extend our previously developed approach for finding the exact analytical form of ground state wave function of single‐electron Schrödinger equations to target arbitrary excited states of 1D model chemical systems of hydrogen atom and with soft Coulomb potential. Our representation of the wave functions is formally unified by a factorized formula involving a polynomial prefactor encoding the nodal information, a non‐integer power prefactor, and an exponentially decaying term modulated by a modulator function. We show that our method leads to faster energy convergence than the basis expansion method, and hence is a better way of representing the wave function. This conclusion is also validated in the real‐world .
A case of a pulmonary‐renal syndrome caused by streptococcal infection
Authors: Shimokawa Junki , Nagano Hiroaki , Raita Yoshihiko 
Published: January 2023

AbstractPulmonary‐renal syndrome (PRS) is defined as a combination of diffuse alveolar haemorrhage and glomerulonephritis. An 18‐year‐old woman visited our hospital with a 2‐day history of fever, dyspnoea, and leg edema. Laboratory investigations revealed an elevated inflammatory reaction, increased serum creatinine levels, and normocytic anaemia. Additionally, the anti‐streptolysin‐O titre was positive, and complement component‐3 levels were decreased. Urinalysis revealed proteinuria and hematuria. Bronchoalveolar lavage aliquots were progressively more hemorrhagic. These findings supported a diagnosis of PRS secondary to streptococcal infection. The patient was treated with high‐dose methylprednisolone and antibiotics. After 4 days of treatment, her respiratory symptoms and serum creatinine levels improved. Steroid tapering was performed over 15 days. The findings in this case indicate that streptococcal infection is a potential cause of PRS, and that short‐term steroid therapy is an effective treatment.
Pleuroparenchymal fibroelastosis in mycobacterium avium complex lung disease
Authors: Sugino Keishi , Ono Hirotaka , Ando Masahiro , Tsuboi Eiyasu 
Published: January 2023

AbstractWe report a rare case of pleuroparenchymal fibroelastosis (PPFE) with interstitial lung disease progressed after an onset of mycobacterium avium complex (MAC) lung disease. Clinicians should pay attention to the management for patients with PPFE in MAC lung disease.
Synthesis of a Novel Hydrazone Functionality based Spectrophotometric Probe for Selective and Sensitive Estimation of Toxic Heavy Metal Ions
Authors: Amin Zainab , Rauf Tabasum , Jan Qounsar , Kuchey Mohammad Yaseen , Sofi Feroz Ahmad , Ismail Tabasum , Rashid Auqib , Bhat Bilal Ahmad , Sidiq Naheed , Bhat Mohsin Ahmad 
Published: January 2023

AbstractHeavy metal ions (HMIs), particularly Hg2+, Fe2+, Pb2+, and Cd2+, are toxic to biological systems. These HMIs display a wide distribution in aqueous systems, and due to their bioaccumulation tendency, their prevalence, even at very low concentrations, results in serious health issues in humans. This warrants the availability of easily affordable, reliable, quick, and sensitive approaches for real‐time monitoring of the concentration of HMIs in aqueous environments. Herein, we present the synthesis of a novel hydrazone functionality‐based chromogenic probe that ensures selective and sensitive spectrophotometric sensing of HMIs. More specifically, the synthesis of 3‐(2‐(2,4‐dinitrophenyl) hydrazono) Penta‐1,4‐diene‐1,5‐diyl) diphenol referred to as HZ in the MS through a two‐step approach via the low‐cost precursors viz. Salicaldehyde, acetone, and 2, 4‐dinitrophenyl hydrazine (2, 4‐DNP) is presented. The unique functionality of the as‐synthesized HZ, well‐characterized via spectroscopic approaches, is demonstrated to facilitate the spectrophotometric sensing of Hg2+, Fe2+, Pb2+, and Cd2+ with detection limits as low as 0.74 μM, 1.46 μM, 0.75 μM, and 0.75 nM respectively. Importantly the spectrophotometric response of HZ is demonstrated to be very sensitive to the nature of HMI, which does ensure selective specification of the chosen HMIs. The sensing ability of the HZ is well within concentration ranges that include WHO‐recommended safe and toxic concentrations for these HMIs.
Synthesis of Graphene oxide/Porphyrin Nanocomposite for Photocatalytic Degradation of Crystal Violet Dye
Authors: Raveena  , Singh Manoj P. , Sengar Manisha , Kumari Pratibha 
Published: January 2023

AbstractA novel nanocomposite was synthesized by covalent functionalization of graphene oxide (GO) with 5,10,15,20‐tetrakis(4‐hydroxyphenyl)porphyrinatoiron (III) chloride (Fe−THPP) via an ester linkage. The synthesized nanocomposite was characterized by various techniques such as XPS, Raman spectroscopy, BET, IR, UV‐Visible, TGA, SEM, and EDX. The synthesized nanocomposite exhibited appreciable interaction with crystal violet (CV) dye with a detection limit of 2.6×10−6 μg/mL and binding constant of 35.93×103 ppm−1 which ensured the high concentration of CV dye on the surface of synthesized photocatalyst. The nanocomposite was effectively utilized in the photo‐degradation of CV dye under visible light irradiation. The photo‐degradation efficiency was remarkably high (93.45 %) with a low catalytic dosage of 0.4 mg/L within 80 minutes. The nanocomposite exhibited good stability and reusability and thereby can be used in the photocatalytic degradation processes to treat wastewater.
Pyrazole‐Clubbed Piperazinyl Urea Derivatives: Synthesis, Characterization and Antimicrobial Studies toward Generating an Antibiotic/Antifungal Resistance Sensor
Authors: Devi Vandana , Phougat Harshita , Kumar Kapoor Jitander , Kumar Sunil , Kumar Vijay , Singh Karan 
Published: January 2023

AbstractAn efficient and practically feasible synthesis of a series of novelpyrazole‐clubbed piperazinyl urea derivatives and screening results of their antimicrobial activity along with current‐voltage studies of selected compounds were reported. The reaction of (1,3‐diaryl‐1H‐pyrazol‐4‐yl)(piperazin‐1‐yl)methanone hydrochlorides with various cycloalkyl/aryl isocyanates under basic condition afforded the formation of target compounds in good to excellent yield. The intermediate compounds 8a,b were synthesized in several steps by the method reported in the literature. The novel synthesized compounds were characterized by various spectroscopic techniques such as IR, 1H NMR, 13C NMR and mass spectra. All the novel urea derivatives have been screened for their antimicrobial activity and some of the derivatives exhibit significant activity against bacterial and fungal isolates. Further current‐voltage (IV) studies were also performed on selected compounds to see the feasibility for generating futuristic antibiotic/antifungal resistance sensor.
Eine Online‐Plattform für die Verarbeitung digitaler visueller Daten zur Zustandsbeschreibung von Beschichtungssystemen an maritimen Stahlbauten
Authors: Momber Andreas , Langenkämper Daniel , Möller Torben , Nattkemper Tim W. 
Published: January 2023

AbstractEs wird eine Online‐Plattform für die Annotation und Verwaltung von visuellen digitalen Daten vorgestellt, die es erstmalig erlaubt, Zustandsbewertung und Instandsetzungsmodellierung von Beschichtungssystemen an maritimen Stahlbauwerken ausschließlich und durchgängig auf der Basis digitaler Bilddaten vorzunehmen. Es wird ein 10‐Schritte‐Verfahren eingeführt, das die Gewinnung der Daten, ihre Übertragung in die Online‐Plattform, die Annotation und Bearbeitung der Daten mittels spezieller Werkzeuge und Methoden, die Modellierung und die Zustandsbewertung umfasst. Anhand von Beispielen werden einige spezielle Anwendungen der Plattform erläutert.
Properties of Water‐Soluble Xylan from Different Agricultural By‐Products and their Production of Xylooligosaccharides
Authors: Palaniappan Ayyappan , Mapengo Clarity R. , Emmambux Mohammad Naushad 
Published: January 2023

AbstractXylooligosaccharides (XOS) are non‐digestible oligosaccharides with a significant role as functional food ingredients in the food industry. The present research is undertaken to evaluate water soluble xylan (WSX) extraction from eight different sources using water at ambient temperature (25 ± 2 °C) and structural characterization (FTIR, NMR, XRD, and TGA). Enzymatic production of XOS from extracted substrates and its characterization using HPLC‐RID and FTIR is determined. WSX from orange fleshed sweet potato peel shows highest yield (9%), while the least (2.48%) is from Teff seed coat. FTIR structural identification of xylan confirms the presence of β‐glycosidic linkages and acetyl groups; whereas 1H NMR validates the occurrence of β‐D‐1,4‐xylopyranose backbone with α‐L‐arabinofuranose and 4‐O‐methylglucuronic acid substituents. XRD and TGA characteristics of the extracts indicate similarities in the eight sources in comparison with standard beech wood xylan. WSX is hydrolyzed with endoxylanase to obtain XOS (highest yield of 57.16 ± 1.01% in Cassava cake; lowest yield of 21.72 ± 0.72% in Bambara groundnut). HPLC‐RID reveals xylobiose as the main monomeric sugar component (DP 2) and β‐linkages are identified by FTIR in all the sources. The study suggests the potential commercial production of XOS from the analyzed agricultural by‐products.
Story Talk: Using Strategies from an Evidence‐Based Program to Improve Young Children's Vocabulary
Authors: Wasik Barbara A. , Hindman Annemarie H. 
Published: January 2023

AbstractStory Talk is an evidence‐based language intervention that has produced significant increases in children's vocabulary (Wasik & Hindman, 2020). This paper begins with a discussion of the importance of language development in learning to read, which is the basis for Story Talk. Next, a description of Story Talk components and the strategies that teachers are trained to implement in this program are presented. Five language strategies, with particular emphasis on developing vocabulary, are discussed in detail. Finally, a description of how Story Talk can look in classrooms is provided so that teachers can visualize how these strategies might work in their own settings during book reading and throughout the day.
The total amount of fluid administered is associated with postoperative complications in head and neck cancer surgery
Authors: Ziegler Andrea , Carollo Erin , Adams William , Bier‐Laning Carol 
Published: January 2023

AbstractObjectivePatients with head and neck cancer often undergo extensive ablative and reconstructive surgery. Many risk factors are unalterable, but some operative variables are possible to adjust. The goal of this study was to estimate the association between operative variables and the incidence of perioperative complications in a contemporary tertiary care university‐based head and neck patient population and a Veteran Administration hospital head and neck patient population from an earlier time period.MethodsWe retrospectively reviewed all patients who underwent major head and neck surgery.ResultsTwo‐hundred‐two university patients and 122 veteran patients were reviewed. On multivariable analysis, the total amount of intravenous (IV) fluid received during the procedure was associated with postoperative complications as were patients’ weight, American Society of Anesthesiologists (ASA) score, and adult comorbidity evaluation‐27 (ACE‐27) score. These associations did not depend on whether the patient was treated at the university or veteran hospital.ConclusionOur study suggests that the odds of a postoperative complication increase as the total amount of IV fluid increases.