bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of a pre-scheduled appointment on attendance in a population-based mammography screening programme
Authors: Goossens Mathijs M , Kellen Eliane , Broeders Mireille J M , Vandemaele Els , Jacobs Brenda , Martens Patrick 
Published: August 2023

Abstract

Background
Pre-scheduled appointments can increase attendance in breast cancer screening programmes compared to ‘open invitations’ but relatively few randomized controlled trials exist. We investigated the effect of a pre-scheduled appointment on uptake in the Flemish population-based mammography screening programme.

Methods
Between September and December 2022, a total of 4798 women were randomly assigned to receive either a pre-scheduled appointment or open invitation. The difference in attendance was compared with Poisson regression analysis for the primary endpoint (attendance ≤92 days after date of invitation), yielding relative risks (RRs). This was done separately for three groups: women invited to a mobile unit and a history of nonattendance (group M-NA); women invited to a hospital-based unit and a history of nonattendance (group HB-NA); women invited to a hospital-based unit and a history of irregular attendance (group HB-IA). There were no women invited to a mobile unit and a history of irregular attendance.

Results
The RRs in favour of the pre-scheduled appointment were 2.3 [95% confidence interval (CI) 1.80–2.88], 1.8 (95% CI 1.07–2.97) and 1.8 (95% CI 1.43–2.39), for groups M-NA, HB-NA and HB-IA, respectively. We found no statistically significant difference between the various RRs. The respective absolute gains in attendance between pre-scheduled appointment and open invitation were 8.3%, 4.4% and 15.8%.

Conclusions
Sending an invitation with a pre-scheduled appointment is an effective tool to increase screening attendance in both mobile and hospital-based screening units. The pre-scheduled appointment is associated with a considerable absolute gain in attendance which varies depending on the screening history.
New Trends, New Possibilities: A Comment on the Proposed Fifth Amendment to China’s Trade Mark Law
Authors: Xu Liang 
Published: August 2023

Abstract
In January 2023, the China National Intellectual Property Administration (CNIPA) released the Draft Amendment to the Trade Mark Law of the PRC (Draft for Public Comment), launching the proposed fifth revision of the Trade Mark Law. This revision comes 40 years after the first version of the Trade Mark Law was implemented. Compared with previous amendments, the Draft makes significant changes, representing a new legislative trend in China’s trade mark law. This comment gives an overview of the background of the fifth amendment and highlights and comments on the fundamental changes in the Draft Amendment.
Perceptions of a prescription model for accessing nicotine vaping products: an examination of submissions made by self-reported e-cigarette users to an Australian consultation
Authors: Jongenelis Michelle I , Robinson Abby , Hughes Anastasia , Pettigrew Simone 
Published: August 2023

Abstract
In response to rapid and substantial increases in rates of e-cigarette use among young people, Australia’s Therapeutic Goods Administration (TGA) made changes to the regulations governing nicotine vaping products. As part of the regulatory change process, Australians were invited to comment on the proposed regulations, which featured the introduction of a prescription model for nicotine vaping products. To inform strategies to enhance compliance with the tightened regulations, this study examined submissions made by self-reported e-cigarette users to the TGA’s public consultation (n = 1405). A content analysis was conducted to identify and quantify key arguments. Claims about possible negative consequences associated with the regulations (e.g. people will return to smoking, inconvenience) featured in most submissions (84%). Around half (55%) of submissions mentioned perceived benefits of e-cigarettes, including favourable health outcomes (e.g. improved breathing) and enhanced tobacco cessation. Around half (52%) featured concerns about inconsistency in treatment and the argument that e-cigarettes should not be restricted when more harmful tobacco products are readily available. Alternative approaches to a prescription model were offered in nearly one-third (31%) of submissions. One-quarter (26%) included text provided by an industry-led astroturfing campaign. The arguments made in the analysed submissions suggest a lack of appreciation of (i) the negative health outcomes associated with e-cigarette use and (ii) evidence linking these devices to smoking relapse. Results highlight the need for targeted health campaigns that address (i) gaps in consumers’ knowledge and (ii) vaping-related misinformation being promulgated by the industry and its allies.
Stargardt disease-associated missense and synonymous ABCA4 variants result in aberrant splicing
Authors: Kaltak Melita , Corradi Zelia , Collin Rob W J , Swildens Jim , Cremers Frans P M 
Published: August 2023

Abstract
Missense variants in ABCA4 constitute ~50% of causal variants in Stargardt disease (STGD1). Their pathogenicity is attributed to their direct effect on protein function, whilst their potential impact on pre-mRNA splicing disruption remains poorly understood. Interestingly, synonymous ABCA4 variants have previously been classified as ‘severe’ variants based on in silico analyses. Here, we systemically investigated the role of synonymous and missense variants in ABCA4 splicing by combining computational predictions and experimental assays. To identify variants of interest, we used SpliceAI to ascribe defective splice predictions on a dataset of 5579 biallelic STGD1 probands. We selected those variants with predicted delta scores for acceptor/donor gain &gt; 0.20, and no previous reports on their effect on splicing. Fifteen ABCA4 variants were selected, 4 of which were predicted to create a new splice acceptor site and 11 to create a new splice donor site. In addition, three variants of interest with delta scores &lt; 0.20 were included. The variants were introduced in wild-type midigenes that contained 4–12 kb of ABCA4 genomic sequence, which were subsequently expressed in HEK293T cells. By using RT-PCR and Sanger sequencing, we identified splice aberrations for 16 of 18 analyzed variants. SpliceAI correctly predicted the outcomes for 15 out of 18 variants, illustrating its reliability in predicting the impact of coding ABCA4 variants on splicing. Our findings highlight a causal role for coding ABCA4 variants in splicing aberrations, improving the severity assessment of missense and synonymous ABCA4 variants, and guiding to new treatment strategies for STGD1.
Overestimating management progress—modelled vs. monitored silver eel escapement in a North Sea draining river
Authors: Höhne Leander , Freese Marko , Pohlmann Jan-Dag , Diekmann Markus , Fladung Erik , Huisman Jeroen B J , Hanel Reinhold , Marohn Lasse 
Published: August 2023

Abstract
The success of European efforts towards the recovery of the European eel (Anguilla anguilla) population will rely on accurate assessments of local stock status for the implementation of conservation measures. Yet, direct and continuous monitoring of the escapement of potential spawners (“silver eels”) is unfeasible in most habitats. Therefore, population models are widely used to estimate local silver eel escapement, but require input information on recruitment, demographic characteristics, and mortalities that are often estimated with great uncertainties. We conducted a combined mark–recapture and acoustic telemetry study across two migration seasons to quantify the actual silver eel escapement in a sub-catchment of the German river Ems. Results were compared with predictions from the demographic model used to provide stock parameters in Germany according to the EU eel-regulation. Mark–recapture results suggested an annual female silver eel escapement of ∼15–17 tons, while the demographic model predicted 90–98 tons, indicating a considerable overestimation. Our results suggest that realistic prediction of silver eel escapement is hardly feasible without high-quality input information and highlight the need for site-specific model calibrations against monitoring data. Overestimations of local stock sizes are problematic if they obscure the necessity for adequate conservation measures, hindering their implementation.
(S)-Ketamine but Not (R)-Ketamine Shows Acute Effects on Depression-Like Behavior and Sleep-Wake Architecture in Rats
Authors: Koncz Szabolcs , Papp Noémi , Pothorszki Dóra , Bagdy György 
Published: August 2023

Abstract

Background
Racemic ketamine consists of two enantiomers, namely (R)-ketamine and (S)-ketamine, with distinguishable pharmacological properties. Both enantiomers have been reported to show rapid antidepressant effects in rodents. Currently, the (S)-enantiomer has been approved for the treatment of major depression, whereas (R)-ketamine failed to show antidepressant effect in recent clinical studies. Major depressive disorder is frequently characterized by disinhibition of rapid eye movement (REM) sleep and disruption of non-REM (NREM) sleep. Racemic ketamine and most conventional antidepressants affect these parameters. However, it remains largely unknown which enantiomer is responsible for these effects.

Methods
Here, we compared acute effects of the two ketamine enantiomers (15 mg/kg i.p.) on different sleep-wake stages in freely moving, EEG-equipped rats. We also evaluated the antidepressant-like activity of the enantiomers in a chronic restraint stress model of depression.

Results
(S)-ketamine but not (R)-ketamine increased REM sleep latency and decreased REM sleep time at 2 and 3 hours, and increased electroencephalogram delta power during NREM sleep. In addition, only (S)-ketamine increased wakefulness and decreased NREM sleep in the first 2 hours. In the forced swimming test, only (S)-ketamine decreased the immobility time of chronically stressed rats.

Conclusion
Effects of the two ketamine enantiomers on rat sleep-wake architecture and behavior are markedly different when administered in the same dose. (S)-ketamine remarkably affects the sleep-wake cycle and very likely sleep-related neuroplasticity, which may be relevant for its antidepressant efficacy. Our results regarding (R)-ketamine’s lack of effect on vigilance and behavior are in line with recent clinical studies.
The Higher Education (Freedom of Speech) Act 2023: An Employment Focused Overview
Authors: Murray James 
Published: August 2023

Abstract
This article considers the provisions of the new Higher Education (Freedom of Speech) Act 2023 and focuses on its employment impact for registered higher education providers in England with respect to the management (in particular, discipline and dismissal) of their staff generally and their academic staff more specifically. Overall, it concludes that the impact on the employment relationship in this context will be significant. Alongside introducing specific provisions related to recruitment, dismissal and discipline of academic staff which will be enforceable through a statutory tort and a complaints scheme, the Act will influence how key aspects of the Employment Rights Act 1996 and the Equality Act 2010 are interpreted.
Counting Security in the Vernacular: Quantification Rhetoric in “Everyday” (In)Security Discourse
Authors: Jarvis Lee 
Published: August 2023

Abstract
Recent years have witnessed a “vernacular turn” in critical security scholarship centered on everyday constructions of (in)security. In this article, I advance this turn by arguing for greater attention to the role of numbers in non-elite discourse on (in)security. Doing so deepens understanding of the mechanisms and registers through which (in)securities are constructed in the vernacular while conceptually strengthening work on vernacular security through insight from literature on the rhetorical, sociological, and political functions of numbers. To pursue this claim, the article develops a new methodological framework through which to explore the work of numbers in vernacular security discourse before applying it to original focus group data on (counter-)radicalization. From this, I highlight the importance of numerical arguments in vernacular constructions of threat, evaluation of security policies, contestation of dominant security discourses, and performances of security literacy.
Future advancement of health care through standardized nursing terminologies: reflections from a Friends of the National Library of Medicine workshop honoring Virginia K. Saba
Authors: Dunn Lopez Karen , Heermann Langford Laura , Kennedy Rosemary , McCormick Kathleen , Delaney Connie White , Alexander Greg , Englebright Jane , Carroll Whende M , Monsen Karen A 
Published: August 2023

Abstract

Objective
To honor the legacy of nursing informatics pioneer and visionary, Dr. Virginia Saba, the Friends of the National Library of Medicine convened a group of international experts to reflect on Dr. Saba’s contributions to nursing standardized nursing terminologies.

Process
Experts led a day-and-a-half virtual update on nursing’s sustained and rigorous efforts to develop and use valid, reliable, and computable standardized nursing terminologies over the past 5 decades. Over the course of the workshop, policymakers, industry leaders, and scholars discussed the successful use of standardized nursing terminologies, the potential for expanded use of these vetted tools to advance healthcare, and future needs and opportunities. In this article, we elaborate on this vision and key recommendations for continued and expanded adoption and use of standardized nursing terminologies across settings and systems with the goal of generating new knowledge that improves health.

Conclusion
Much of the promise that the original creators of standardized nursing terminologies envisioned has been achieved. Secondary analysis of clinical data using these terminologies has repeatedly demonstrated the value of nursing and nursing’s data. With increased and widespread adoption, these achievements can be replicated across settings and systems.
Predicting dry matter intake in beef cattle
Authors: Blake Nathan E , Walker Matthew , Plum Shane , Hubbart Jason A , Hatton Joseph , Mata-Padrino Domingo , Holásková Ida , Wilson Matthew E 
Published: August 2023

Abstract
Technology that facilitates estimations of individual animal dry matter intake (DMI) rates in group-housed settings will improve production and management efficiencies. Estimating DMI in pasture settings or facilities where feed intake cannot be monitored may benefit from predictive algorithms that use other variables as proxies. This study examined the relationships between DMI, animal performance, and environmental variables. Here we determined whether a machine learning approach can predict DMI from measured water intake variables, age, sex, full body weight, and average daily gain (ADG). Two hundred and five animals were studied in a drylot setting (152 bulls for 88 d and 53 steers for 50 d). Collected data included daily DMI, water intake, daily predicted full body weights, and ADG using In-Pen-Weighing Positions and Feed Intake Nodes. After exclusion of 26 bulls of low-frequency breeds and one severe (&gt;3 standard deviations) outlier, the final number of animals used for modeling was 178 (125 bulls, 53 steers). Climate data were recorded at 30-min intervals throughout the study period. Random Forest Regression (RFR) and Repeated Measures Random Forest (RMRF) were used as machine learning approaches to develop a predictive algorithm. Repeated Measures ANOVA (RMANOVA) was used as the traditional approach. Using the RMRF method, an algorithm was constructed that predicts an animal’s DMI within 0.75 kg. Evaluation and refining of algorithms used to predict DMI in drylot by adding more representative data will allow for future extrapolation to controlled small plot grazing and, ultimately, more extensive group field settings.
War Crimes Involving Autonomous Weapons
Authors: Lewis Dustin A 
Published: August 2023

Abstract
This article identifies and evaluates key international legal aspects concerning three notions that have figured in debates on war crimes involving an autonomous weapon system (AWS): responsibility, liability and accountability. It focuses on the general contours of the existing international law of armed conflict, also known as international humanitarian law (IHL), and related fields, concepts and institutions. Regarding responsibility, this article examines, on one hand, the international responsibility of a state for an internationally wrongful act related to a breach of a rule of IHL involving an AWS that may form the basis of a war crime and, on the other hand, individual criminal responsibility for a war crime involving an AWS. As for liability, this article outlines three international legal concepts of state liability potentially related to a war crime involving an AWS. Finally, this article sets out an, at least, legally adjacent concept of accountability that involves an explanation of the conduct related to a war crime involving an AWS and imposing political, legal, social or other consequences where such an explanation is absent or insufficient.
Gut microbial diversity and function analysis of the final-instar larvae of Protohermes xanthodes (Megaloptera: Corydalidae)
Authors: Shen Zaiyun , Cao Chengquan , Xia Xiaofeng 
Published: August 2023

Abstract
Protohermes xanthodes (Megaloptera, Corydalidae, Protohermes), widespread species in China, is an important insects treated as food and medicine for aquaculture. In this study, the gut microbiota was investigated by 16S rRNA microbial profiling. A total of 600 Amplicon Sequence Variants (ASV) were identified, Proteobacteria and Firmicutes were the main dominant phyla, and 27 genera ran through the entire digestive tract, mainly Hafnia-Obesumbacterium (Proteobacteria), Lactobacillus and Lactococcus (Firmicutes). The PICRUSt2 functional prediction of gut microbiota showed that the foregut abundant pathways related to metabolism, environmental information processing, and genetic information processing. while the midgut had the most abundant metabolic and environmental information processing pathways, including the prominent phosphotransferase system (PTS), propionate metabolism, and β-lactam resistance. The hindgut had the weakest metabolic function, but its genetic information processing was more abundant than the foregut and midgut. Additionally, 26 strains of bacteria were isolated from the midgut microorganisms, with Firmicutes being the dominant bacteria, and some of the purified bacteria had potential probiotic and anti-pathogen functions. These findings suggest that there are differences in the microorganisms of the different gut floras of the larvae, and each flora has specific metabolic functions. This research could be used to further understand the function of gut microorganisms, explore the co-evolution of P. xanthodes and gut microorganisms, and promote healthy breeding based on gut microorganisms.
Non-operative management involving chemoradiation therapy combined with high-dose-rate brachytherapy for T3 rectal cancer using a vaginal shielded cylindrical applicator: a technical report
Authors: Murakami Naoya , Kojima Kanako , Okuma Kae , Kashihara Tairo , Nakamura Satoshi , Shimizu Wakako , Suda Ryuichiro , Igaki Hiroshi , Shikama Naoto 
Published: August 2023

Abstract
It has been shown that a group of rectal cancer patients will achieve a pathological complete response following preoperative chemoradiotherapy, and non-operative management has recently gained attention. To escalate the tumour dose and increase the likelihood of pathological complete response, brachytherapy can play an important role in safely increasing the total dose. However, at the time this report was published, an applicator dedicated to rectal brachytherapy was unaffordable in Japan. Here, we report two T3 rectal cancer patients who were inoperable or refused surgery and treated by chemoradiotherapy following intracavitary brachytherapy involving a vaginal cylinder applicator with lead shielding.
Hume on Modal Projection
Authors: Ehli Bridger 
Published: August 2023

Abstract
Hume’s claim that we project necessity onto objects we take to be causally related has been influential in contemporary discussions of modality, inspiring deflationary accounts of our modal commitments. Hume is commonly understood as holding that modal projection explains our judging that an effect must follow its cause. This misunderstands the role of projection in Hume’s discussions of causation and causal judgement. Projection is a diagnosis of a distinctively philosophical confusion: the commitment to mind-independent necessary connections. In arguing for this, I provide an account of the psychological process that, in Hume’s view, underlies projection. This account resolves problems with Hume’s projectivism identified by his commentators.
Explanationism versus Modalism in Debunking (and Theory Choice)
Authors: Bhogal Harjit 
Published: August 2023

Abstract
At the core of the recent debate over moral debunking arguments is a disagreement between explanationist and modalist approaches. Explanationists think that the lack of an explanatory connection between our moral beliefs and the moral truths, given a non-naturalist realist conception of morality, is a reason to reject non-naturalism. Modalists disagree. They say that, given non-naturalism, our beliefs have the appropriate modal features with respect to truth – in particular they are safe and sensitive – so there is no problem. There is a stand-off here. I argue, though, that by looking at the role explanatory and modal factors have to play in theory choice more generally, and, in particular, by considering the practice of theory choice in science, we can see that the explanationist is right. The lack of an explanatory connection between our moral beliefs and the moral truths is a reason to reject non-naturalist realism about morality.