bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of cardiometabolic risk factors on blood pressure in outpatients at Sominé DOLO hospital, Mopti, Mali
Authors: Coulibaly Modibo , Kondé Adama , Traoré Djibril , Bah Ousmane , Sagara Valentin , Maiga Bakary 
Published: April 2023

Blood cardiometabolic impairments are associated to high blood pressure which is a pivot cardiovascular risk factor. The objective of this study was to assess cardiometabolic risk factors rates in subjects with high blood pressure in the steady state. A total of 292subjects, 107 cases and 185 controls were enrolled in cross-sectional study. Clinical and biological data were assessed during visits and after overnight fasting. Data were analyzed on R. A p-value &#60; 0.05 was considered for statistical significance.Univariate analysis showed thatage &#62; 50 years, visceral obesity, metabolic syndrome and hs- CRP ≥ 3 mg/L were significant predictors of high blood pressure: OR = 2.1, 95% CI [1.3-3.5], p = 0.003; OR = 1.6, 95% CI [1.0-2.6], p = 0.05; OR = 3.3; 95% CI [2.0-5.4], p &#60; 0.001; OR = 16.8; 95% CI [9.4-31.4], p &#60; 0.001, respectively. Multivariate analysis showed a positive association between obesity, metabolic syndrome, hs-CRP and high blood pressure: aOR = 2.29; 95% CI [1.14-4.69], p = 0.02; aOR = 3.47; 95% CI [1.64-7.61], p = 0.001; aOR = 18.10; CI, 2.5% to 95% [9.40-36.99], p &#60; 0.001, respectively. In contrast, female sex was negatively associated with high blood pressure aOR = 0.31; CI, 95% CI [0.13-0.72], p &#60; 0.008. Prevention policiesshould take into account blood cardiometabolic level for subjects with high blood pressure even though in the steady sate.
Safety and tolerability of agalsidase beta infusions shorter than 90 minutes in patients with Fabry disease: post-hoc analysis of a Japanese post-marketing study
Authors: Lee Chae Sung , Tsurumi Mina , Eto Yoshikatsu 
Published: April 2023

Abstract
Background: Agalsidase beta, an enzyme replacement therapy for Fabry disease, is dosed biweekly at 1 mg/kg body weight, with increasing infusion rates based on tolerability. The US label specifies ≥90-minute infusions for all patients; the US and EU labels require ≤15 mg/hr infusions in patients <30 kg. The Japanese label allows infusions up to 30 mg/hr, allowing <90-minute dosing for some patients weighing <45 kg. Japanese post-marketing data were analyzed for rate of infusion-associated reactions (IARs), adverse events (AEs), and serious AEs (SAEs) based on infusion rate and patient attributes (weight, antibody status).
Results: Data were available for 436 reduced-duration infusions (<90 minutes) and 2,242 standard infusions (≥90 minutes). SAEs were rare (0.6%), and the frequency of all safety events decreased over the treatment course. Little impact of infusion duration on safety outcomes was observed: IARs and AEs were numerically more common when infusion duration was ≥90 minutes compared to <90 minutes (IARs: 2.0% vs 0.9%; AEs: 2.9% vs 1.4%), while the rate of SAEs was similar (0.4% vs 0.5%). IAR, AE, and SAE frequencies decreased significantly with increasing infusion rates, and this trend was consistent in patients <30 kg. Safety events tended to be less frequent in patients <30 kg vs those ≥30 kg (IARs: 1.8% vs 2.1%; AEs: 2.3% vs 3.6%; SAEs: 0.0% vs 0.6%), although the differences were not statistically significant. IARs occurred in <1% of all infusions in the <30 kg group, 84% of which were <90 minutes. More anti-agalsidase beta antibody-positive patients experienced IARs (41.9% vs 30.7%; P=0.0445) and AEs (61.1% vs 49.3%; P=0.0497) vs antibody-negative patients; however, there was no significant difference in the frequency of SAEs.
Conclusions: The results of this post-hoc analysis demonstrated no significant impact of infusion duration on safety outcomes, and no significant difference in outcomes between patients of different weights. These findings suggest that infusion times in patients who are tolerating treatment can, with careful monitoring, be gradually decreased.
Dimethyl fumarate as a covalent inhibitor of Cathepsin C: a novel mechanism of action explored in in-vitro and in-vivo.
Authors: Alam Qadir , Krishnamurthy Sairam , Tomar Munendra 
Published: April 2023

Abstract
Dimethyl fumarate (DMF) is an enoate ester approved for treating autoimmune diseases like relapsing-remitting multiple sclerosis (RRMS) and psoriasis. Although its efficacy is attributed to its immunomodulatory properties but the exact mechanism of action is undeciphered. DMF tends to make Michael-adduct with cysteine residues of enzymes. The current study focuses on in-vitro experiments to find out the time-dependent enzyme inhibition of cathepsin C, which is an essential upstream target for immune cells controlling apoptosis. An in-vivo study was also performed by inducing experimental autoimmune encephalitis (EAE) on the day-1 of the experiment, and clinical scoring was done after 4 hours onwards up to day-33. Oral drug treatment was done from day-7 onwards with DMF-50 mg/kg. A significant improvement in the clinical score with DMF treatment compared to the EAE group has been observed. DMF has been shown to ameliorate demyelination in the spinal cord and reduce CD8+ and CD4+ T lymphocyte infiltration in the CNS. Moreover, a significant reduction in the cathepsin C activity and its downstream granzyme B activity in the CNS on day-33 has been noticed. The irreversible inhibition of cathepsin C indicates the efficacy of DMF on mononuclear cells.
Impact of SARS-CoV-2 infection and vaccination on migraine symptoms during the COVID-19 pandemic
Authors: Silva Lénia , Lopes Adriana , Pontes Ana , Gonçalves Ana , Chiteculo Arlinda , Soares Beatriz , Teixeira Inês , Gonçalves Maria , Alves Maria , Cardia Maria , Monteiro Mariana , Eiras Raquel , Costa Sara , Laranjinha Inês , Andrade Carlos , Gabriel Denis 
Published: April 2023

Abstract
Introduction
Migraine is one of the most disabling neurological diseases and is aggravated by anxiety, stress, and sleep dysfunction. Recent studies have shown worsening of migraine associated with the COVID-19 infection and the pandemic more broadly. COVID-19 vaccination has also been associated with symptomatic headache, with high frequency among migraineurs. We aim to assess the impact of COVID-19 diagnosis and vaccine administration on migraine, during the SARS-CoV-2 pandemic.
Methods
An online questionnaire was sent to migraine patients followed in a neurology outpatient clinic. The survey inquired about migraine symptoms and treatment changes, as well as sleep changes, anxiety and depressive symptoms during the pandemic, after a COVID-19 diagnosis and/or vaccination.
Results
Out of the 185 patients included, 108 (58.4%) reported a change in headache pattern (42% before a COVID-19 diagnosis) and 72.2% needed to escalate treatment during the pandemic, regardless of infection. Migraine worsening was associated with higher rates of persistent symptomatic headache. A change in sleep pattern was more frequently reported in migraineurs after COVID-19 and in the group with worsening migraine. Abnormal levels of anxiety and depression were high among patients with worsening migraine, irrespective of COVID-19 diagnosis. After vaccination, 49 (27.1%) described a change in headache pattern, with worsening pattern in 29 (16%), 48% up to 3 weeks.
Conclusion
Worsening of migraine was more likely associated to psychosocial factors related to the pandemic rather than COVID-19 diagnosis per se. COVID-19 vaccination might have acted as an additional but less relevant and temporary trigger for migraine worsening.
Dermis resident macrophages orchestrate
localized ILC2-eosinophil circuitries to maintain their M2-like properties and promote
non-healing cutaneous leishmaniasis
Authors: Lee Sang Hun , Kang Byunghyun , Kamenyeva Olena , Ferreira Tiago , Cho Kyoungin , Khillan Jaspal , Kabat Juraj , Kelsall Brian , Sacks David 
Published: April 2023

Abstract
Tissue-resident macrophages (TRMs) are critical for tissue homeostasis/repair. We previously showed that dermal TRMs produce CCL24 (eotaxin2) which mediates their interaction with IL-4 producing eosinophils, required to maintain their number and M2-like properties in the TH1 environment of the Leishmania major infected skin. Here, we unveil another layer of TRM self-maintenance involving their production of TSLP, an alarmin typically characterized as epithelial cell-derived. Both TSLP signaling and IL-5+ innate lymphoid cell 2 (ILC2s) were shown to maintain the number of dermal TRMs and promote infection. Single cell RNA sequencing identified the dermal TRMs as the sole source of TSLP and CCL24. Development of Ccl24-cre mice permitted specific labeling of dermal TRMs, as well as interstitial TRMs from other organs. Genetic ablation of TSLP from dermal TRMs reduced the number of dermal TRMs, and disease was ameliorated. Thus, by orchestrating localized type 2 circuitries with ILC2s and eosinophils, dermal TRMs are self-maintained as a replicative niche for L. major.
Artificial intelligence system for evaluating county-level government social governance based on heterogeneous network
Authors: Ma Yutong , Xie Bingxue 
Published: April 2023

Abstract
With the rapid development of mobile communication network technology and the increase of various demands, users have put forward higher requirements for the performance of today's communication technology. Different types of communication subnets can be combined to create different heterogeneous network technologies, which can effectively expand network coverage and improve system communication performance. This paper studies the allocation and decomposition of D2D resources into different heterogeneous network systems. In contrast, this article optimizes the functions of the social information system based on management needs, and integrates the artificial intelligence system into a multi-case study method set of three components based on the correlation between the advantages of the equal embedded artificial intelligence system, and integrates the social management the most common situations in information systems are the subject of research. Research shows that the three basic elements of artificial intelligence systems have been incorporated into social management information systems. The ability, perception, and political promotion of the artificial intelligence system were unearthed, thereby establishing a county-level government social governance evaluation system. Reasonably determining the weights of indicators at all levels is the key to a reasonable assessment of social governance. The weight values ​​of indicators at all levels directly affect the results of the comprehensive evaluation of social governance by county-level governments. The indicator system should use expert scoring methods to determine the weight of each indicator. In terms of data collection, it can be collected through annual statistical data and questionnaire data. Finally, a comprehensive social governance index will be formed for county-level governments, and further research and analysis will be required in terms of index analysis, weighting, and data availability.
Application of fuzzy image processing and Iot real-time monitoring in sports training mode
Authors: Shi Longlong , Liu Siwen , Zhang Ligong , Zhu Yongguo 
Published: April 2023

Abstract
Blurred images are very complicated because imaging is affected by computer technology, sensor technology, vision, mathematics, environment, human activities, etc. Sometimes the available visual information is not what we can accept. The image sometimes has poor contrast, and due to different levels of damage, the sound or blind spots are also different. The Internet of Things has become the main focus of the industry. It can be considered as an extension of the three existing networks of Internet, telecommunications, and radio and television networks. And it gradually surpassed the interaction of people's information, and expanded to the information exchange between people and things, things and people, things and things. With the rapid development of the Internet of Things technology, especially the diversity of remote transmission methods and the improvement of the technical level, the remote real-time monitoring of the Internet of Things has been more and more widely used in the Internet. In the IoT monitoring system, the service is the bridge between data collection and data application. In order to improve the efficiency of the communication module and support the availability of multiple devices, it is very important to design an efficient communication server. Through real-time analysis of the exercise data brought by multiple students, personalized exercise training plans can be customized according to the different physiques of the students. It can be seen from the results of the simulation experiment that whether it is a separate analysis or an objective judgment, the test results show that the method in this paper is effective and it is possible to improve the image quality.
Superconductivity in Twisted Bilayer Graphene: Cooper-pairs distribution function analysis
Authors: González-Pedreros Guillermo , Camargo-Martínez Jose , Mesa Fredy 
Published: April 2023

Abstract
Cooper-pair distribution function Dcp(ω, Tc) for Twisted Bilayer Graphene (TBLG) in the presence of an external electric field is presented. The TBLG structure is proposed in the geometric approximation frame that allows mimicking structures with layers rotated in tiny angles, avoiding supercell calculations. The results show that the proposed geometric method manages to reproduce TBLG theoretical calculations reported in the literature in a good approximation. Dcp(ω, Tc) for TBLG suggests that Cooper-pairs are possible in the low-frequency vibration region. The calculations appear to be consistent with the existence of the superconducting state in TBLG, and it allows us to suggest the effect of the electric field for specific angles of rotation of TBLG.
Effects and challenges of public-health measures for zeroing out emerging contagions with varying transmissibility
Authors: Lai Shengjie , Ge Yong , Wu Xilin , Zhang Wenbin , Wang Xiaoli , Zhang Die , Wang Jianghao , Liu Haiyan , Ren Zhoupeng , Ruktanonchai Nick , Ruktanonchai Corrine W. , Cleary Eimear , Yao Yongcheng , Wesolowski Amy , Cummings Derek A.T. , Li Zhongjie , Tatem Andrew 
Published: April 2023

Abstract
Targeted public health interventions for an emerging epidemic are essential for preventing pandemics and reducing their impact on health and society. During 2020–2022, China invested significant efforts in strict zero-COVID policies to contain outbreaks of varying scales caused by different SARS-CoV-2 variants. This presented a unique opportunity to utilise a real-world dataset to investigate the effects and challenges of public health interventions aimed at eliminating local transmission of emerging or introduced respiratory infections in diverse settings. Based on a multi-year empirical dataset containing 131 outbreaks observed in China from April 2020 to May 2022 and simulated scenarios, we ranked the relative effectiveness of the public health interventions by their reduction in instantaneous reproduction number. We found that, overall, reducing physical contact between individuals was most effective (median 23%, interquartile range [IQR] 20–26%), followed by the use of face masks (19%, IQR 16–23%) and close contact tracing (15%, IQR 14–16%). However, contact tracing played a more critical role in containing outbreaks during the initial phases, but as the spread persisted, social distancing measures became increasingly prominent and mass screening likely had little effect. In addition, these measures struggled to zero out infections that had high transmissibility and a short latent period, regardless of population size. Our findings provide quantitative insights on the impacts of different rapid public-health responses against emerging contagions with varying epidemiological and socio-economic contexts.
An Analysis of FPGA LUT Bias and Entropy for Physical Unclonable Functions
Authors: Jao Jenilee , Wilcox Ian , Thotakura Sriram , Chan Calvin , Plusquellic Jim , Paskaleva Bilana S , Bochev Pavel B 
Published: April 2023

Abstract
Process variations within Field Programmable Gate Arrays (FPGAs) provide a rich source of entropy and are therefore well-suited for the implementation of Physical Unclonable Funtions (PUFs). However, careful considerations must be given to the design of the PUF architecture as a means of avoiding undesirable localized bias effects that adversely impact randomness, an important statistical quality characteristic of a PUF. In this paper, we investigate a ring-oscillator (RO) PUF that leverages localized entropy from individual look-up table (LUT) primitives. A novel RO construction is presented that enables the individual paths through the LUT primitive to be measured and isolated at high precision and an analysis is presented that demonstrates significant levels of localized design bias. The analysis demonstrates that delay-based PUFs that utilize LUTs as a source of entropy should avoid using FPGA primitives that are localized to specific regions of the FPGA, and instead a more robust PUF architecture can be constructed by distributing path delay components over a wider region of the FPGA fabric. Compact RO PUF architectures that utilize multiple configurations within a small group of LUTs are particularly susceptible to these types of design-level bias effects. The analysis is carried out on data collected from a set of identically-designed, hard macro instantiations of the RO implemented on 30 copies of a Zynq 7010 SoC.
Histone Deacetylase Inhibitors inhibit lung adenocarcinoma metastasis via HDAC2/YY1 mediated downregulation of Cdh1
Authors: Wang Dongmei , Yang Yixiao , Cao Yuxiang , Meng Meiyao , Wang Xiaobo , Zhang Zhengxun , Fu Wei , Duan Shichao , Tang Liming 
Published: April 2023

Abstract
Metastasis leads to high mortality of lung adenocarcinoma patients. Histone deacetylases are reliable targets of anti-tumor drugs, and histone deacetylase inhibitors (HDACi) have become a hot field of anti-tumor drug research. However, the specific mechanisms by which HDACi inhibits lung cancer metastasis have not been fully elucidated. Here, we detected the role of HDACi and HDAC2/YY1 in the process of lung adenocarcinoma migration by qPCR, immunobloting, co-immunoprecipitation, chromatin-immunoprecipitation and cell migration assay, combined with online database analysis. We found both trichostatin A (TSA) and sodium butyrate (NaBu) inhibit lung cancer cell invasion and migration significantly via Histone Deacetylase 2 (HDAC2). HDAC2 overexpression promotes lung cancer cell migration, while shHDAC2 inhibits lung cancer cell migration obviously. Further investigation show that HDAC2 interacts with YY1 and deacelytes Lycine 27 of Histone 3 to inhibits Cdh1 transcriptional activity and then promotes cell migration. This study revealed a new functional mechanism of HDAC2/YY1 in lung adenocarcinoma cell migration.
Clinical control study of acute idiopathic abducens nerve palsy treated with injections of dexamethasone into the lateral rectus muscle
Authors: Shi Minghua , Qin Aijiao , Cheng Jing , Ren Hongxing , Chen Simin , Xing Yiqiao 
Published: April 2023

Abstract
PURPOSE:
To explore the efficacy and safety of local injections of dexamethasone into the lateral rectus muscle for treatment of acute idiopathic abducens nerve palsy (AIANP).
METHODS:
A study group and a control group were established for this study. The former received dexamethasone injections into the paralyzed lateral rectus muscle in combination with oral mecobalamin tablets. The control group only received mecobalamin tablets for no more than two months. The follow-up period was > 6 months. Incidence of lateral rectus palsy and diplopia were recorded, as well as complications.
RESULTS:
Between September 2019 and September 2022, a total of 72 patients with AIANP were included in this study (mean age: 54.1 ± 15.8 y). After treatment, all 39 patients in the study group were successfully treated (100%), while only 27/33 (81.8%) patients in the control group were successfully treated. This difference between groups was statistically significant (Fisher’s exact test, P = 0.01). Recovery times for the two groups also differed (3.45 ± 1.49 weeks vs. 12.1 ± 9.83 weeks, respectively; P < 0.001). Among the two groups, only one case of conjunctival congestion was reported at the injection site in the treatment group. Furthermore, recurrence was not observed during the follow-up period (17.9 ± 8.17 months).
CONCLUSION:
Dexamethasone injections into the lateral rectus muscle of AIANP patients are found to be a safe and effective treatment. They also improved the treatment rate and shortened treatment time．
An infant with hand dorsal compartment syndrome due to intravenous infiltration of glucose-acetate Ringer's solution
Authors: Tomori Shinya , Korematsu Seigo , Momose Taichi , Urushihara Yasuko , Moriwaki Koichi 
Published: April 2023

Abstract
Introduction: Compartment syndrome caused by infusion pump in children has not been sufficiently reported.
Case presentation: A five-month-old boy was admitted to the hospital and underwent decompression of a dorsal hand compartment while receiving only glucose-acetate Ringer's solution.
Conclusion: Infiltration, a commonly seen complication with intravenous fluids and their administration, can cause compartment syndrome due to a variety of factors and should be treated promptly when infiltration or extravasation is detected. Guidelines and recommendations for the management of such cases have not been sufficiently described, and specific guidelines to prevent and detect fluid leakage early in infants are necessary.
Advanced Operation of Heated Fluidic Resonators via Mechanical and Thermal Loss Reduction in Vacuo
Authors: Lee Jungchul , Ko Juhee , Lee Bong Jae 
Published: April 2023

Abstract
For simultaneous and quantitative thermophysical properties measurements of ultra-small liquid volume, we have recently developed and reported heated fluidic resonators (HFRs). In this paper, we improve the precision of HFRs in vacuum by significantly reducing thermal loss around the sensing element. A vacuum chamber with optical, electrical, and microfluidic access is custom-made to decrease the convection loss by two orders of magnitude at 10-4 mbar. As a result, measurement sensitivities for thermal conductivity and specific heat capacity are increased by 4.1 and 1.6 times, respectively. Upon differentiation between deionized water (H2O) and heavy water (D2O) exhibiting similar thermophysical properties but ~10% different mass density, signal-to-noise ratios, property difference between H2O and D2O divided by the standard error, are increased by 9 and 5 times for thermal conductivity and specific heat capacity, respectively.