bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genetic Landscape of Major Depressive Disorder: Assessment of Potential Diagnostic and Antidepressant Response Markers
Authors: Singh Priyanka , Srivastava Ankit , Guin Debleena , Thakran Sarita , Yadav Jyoti , Chandna Puneet , Sood Mamta , Chadda Rakesh Kumar , Kukreti Ritushree 
Published: January 2023

AbstractBackgroundThe clinical heterogeneity in major depressive disorder (MDD), variable treatment response, and conflicting findings limit the ability of genomics toward the discovery of evidence-based diagnosis and treatment regimen. This study attempts to curate all genetic association findings to evaluate potential variants for clinical translation.MethodsWe systematically reviewed all candidates and genome-wide association studies for both MDD susceptibility and antidepressant response, independently, using MEDLINE, particularly to identify replicated findings. These variants were evaluated for functional consequences using different in silico tools and further estimated their diagnostic predictability by calculating positive predictive values.ResultsA total of 217 significantly associated studies comprising 1200 variants across 545 genes and 128 studies including 921 variants across 412 genes were included with MDD susceptibility and antidepressant response, respectively. Although the majority of associations were confirmed by a single study, we identified 31 and 18 replicated variants (in at least 2 studies) for MDD and antidepressant response. Functional annotation of these 31 variants predicted 20% coding variants as deleterious/damaging and 80.6% variants with regulatory effect. Similarly, the response-related 18 variants revealed 25% coding variant as damaging and 88.2% with substantial regulatory potential. Finally, we could calculate the diagnostic predictability of 19 and 5 variants whose positive predictive values ranges from 0.49 to 0.66 for MDD and 0.36 to 0.66 for response.ConclusionsThe replicated variants presented in our data are promising for disease diagnosis and improved response outcomes. Although these quantitative assessment measures are solely directive of available observational evidence, robust homogenous validation studies are required to strengthen these variants for molecular diagnostic application.
Error estimates for physics-informed neural networks approximating the Navier–Stokes equations
Authors: De Ryck Tim , Jagtap Ameya D , Mishra Siddhartha 
Published: January 2023

Abstract
We prove rigorous bounds on the errors resulting from the approximation of the incompressible Navier–Stokes equations with (extended) physics-informed neural networks. We show that the underlying partial differential equation residual can be made arbitrarily small for tanh neural networks with two hidden layers. Moreover, the total error can be estimated in terms of the training error, network size and number of quadrature points. The theory is illustrated with numerical experiments.
P22 Patient-level meta-analysis of efficacy and safety from STRIVE and ReSTORE: randomized, double-blinded, multicentre Phase 2 and Phase 3 trials of rezafungin in the treatment of candidaemia and/or invasive candidiasis
Authors: Soriano A , Thompson G R , Cornely O A , Kullberg B J , Kollef M , Vazquez J , Honore P M , Bassetti M , Pullman J , Dignani C , Das A F , Sandison T , Pappas P G 
Published: January 2023

Abstract

Background
Rezafungin is a next-generation echinocandin in development for treatment of candidaemia and invasive candidiasis (IC) and for prevention of invasive fungal disease caused by Candida, Aspergillus and Pneumocystis spp. in blood and marrow transplantation. Rezafungin once-weekly (QWk) was compared to caspofungin once-daily (QD) in two double-blind, randomized, controlled trials in patients with candidaemia and/or IC: STRIVE (Phase 2; NCT02734862) and the recently completed ReSTORE (Phase 3; NCT03667690). STRIVE demonstrated the efficacy and safety profile of rezafungin. ReSTORE showed rezafungin noninferiority to caspofungin for 30 day all-cause mortality (ACM) and global response at Day 14 with comparable safety. Patient-level meta-analyses of efficacy and safety from both trials are presented.

Methods
Details of STRIVE and ReSTORE were previously described. In this analysis of data from both trials, patients who received rezafungin QWk (400 mg in Week 1, then 200 mg) were compared with those who received caspofungin QD (70 mg on Day 1 followed by 50 mg) for ≥14 days (up to 4 weeks). Efficacy endpoints included 30 day ACM (primary US FDA), mycological response at Day 5 (secondary), and time to first negative blood culture (TTNBC) (exploratory). Safety was evaluated by adverse events (AEs).

Results
Groups were well matched (Table 1). Figure 1 shows 30 day ACM (overall and by final diagnosis). Mycological response at Day 5 was 73.4% (102/139) and 64.5% (100/155) in rezafungin and caspofungin groups, respectively (difference=9.5, 95% CI=−0.9, 19.9). In patients with positive blood culture before randomization, median TTNBC was 22.3 h in rezafungin-treated versus 26.3 h in caspofungin-treated patients (stratified log rank p=0.0034, not adjusted for multiplicity). The summary of AEs (Table 2) demonstrates similar outcomes for rezafungin and caspofungin groups.

Conclusions
In the Phase 2/3 patient-level meta-analysis, rezafungin QWk demonstrated efficacy with a similar 30 day ACM rate and safety comparable to that of caspofungin QD. Data for mycological eradication at Day 5 and TTNBC support results from the primary efficacy endpoint and provide initial evidence for the theory that high, front-loaded drug exposure leads to faster fungal clearance. Further analysis of this integrated dataset may provide additional insights on rezafungin efficacy and safety.
The PhenX Toolkit: standard measurement resources for cancer outcomes and survivorship research
Authors: Nekhlyudov Larissa , Bellizzi Keith , Galligan Andrew , King-Kallimanis Bellinda , Mayer Deborah K , Miaskowski Christine , Salz Talya , McCarty Catherine , Cox Lisa , Hill Christine , Hendershot Tabitha P , Maiese Deborah R , Hamilton Carol M 
Published: January 2023

AbstractThis brief report introduces the Cancer Outcomes and Survivorship domain in the PhenX Toolkit (consensus measures for Phenotypes and eXposures), which includes 15 validated measurement protocols for cancer survivorship research that were recommended for inclusion in this publicly available resource. Developed with input from the scientific community, the domain provides researchers with well-established measurement protocols for evaluating physical and psychological effects, financial toxicity, and patient experiences with cancer care. The PhenX Toolkit, funded by the National Human Genome Research Institute since 2007, is an online resource that provides high-quality standard measurement protocols for a wide range of research areas (eg, smoking cessation, harm reduction and biomarkers, and social determinants of health). Use of the PhenX Cancer Survivorship Outcomes and Survivorship domain can simplify the selection of measurement protocols, data sharing, and comparisons across studies investigating the cancer survivorship experience.
Same Same but Different? Ideological Differentiation and Intra-jihadist Competition in the Syrian Civil War
Authors: Schwab Regine 
Published: January 2023

AbstractHow do rebel groups survive and thrive in multiparty civil wars where numerous groups not only fight against a common enemy but also compete with each other for support, recruits, and resources? Literature on the internal dynamics of civil wars has mostly focused on violence as the negative side of inter-rebel competition. The aim of this paper is threefold: First, it aims at explaining when armed groups attempt to use ideological differentiation instead of violence against rivals. Second, it analyzes when this strategy will succeed, and third, it demonstrates what successful differentiation means. The argument is probed by analyzing the puzzling case of Ahrar al-Sham in the Syrian war that emerged as both winner and loser of intra-jihadist competition with the Islamic State in Iraq and Syria (ISIS) and Jabhat al-Nusra/Hayat Tahrir al-Sham. Next to offering a new and original analysis of one of the most important Syrian insurgent groups based on interviews and primary documents, the article studies an under-researched rebel strategy whose use is relevant not only for armed groups themselves but also for local civilians, prospective recruits, and external supporters.
Parental Mental Health and Parenting Behaviors Following Very Preterm Birth: Associations in Mothers and Fathers and Implications for Child Cognitive Outcome
Authors: McMahon Grace E , Treyvaud Karli , Spittle Alicia J , Giallo Rebecca , Lee Katherine J , Cheong Jeanie L , Doyle Lex W , Spencer-Smith Megan M , Anderson Peter J 
Published: January 2023

AbstractObjectivesTo investigate the longitudinal associations between parental mental health symptoms within 4 weeks of birth, parenting behaviors at 1 year, and child general cognitive ability at 4.5–5 years in a sample of children born very preterm (VP). This study also examined whether these associations differed based on level of family social risk.MethodsParticipants were 143 children born &lt;30 weeks’ gestation and their parents. Within 4 weeks of birth, mothers’ and fathers’ depressive and anxiety symptoms were assessed using the Center for Epidemiologic Studies Depression Scale and Hospital Anxiety Depression Scale-Anxiety Subscale. Parents’ sensitive and structuring parenting behaviors were assessed at 1 year using the Emotional Availability Scales. Child general cognitive ability was assessed at 4.5–5 years using the Wechsler Preschool & Primary Scale of Intelligence–Fourth Edition.ResultsHigher maternal depressive symptoms were associated with lower levels of sensitive and structuring parenting behavior, while higher maternal anxiety symptoms were associated with higher levels of structuring parenting behavior. There was weak evidence for positive associations between mothers’ sensitive parenting behavior and fathers’ structuring parenting behavior and child general cognitive ability. There was also weak evidence for stronger associations between mothers’ mental health symptoms, parenting behaviors, and child general cognitive ability, in families of higher compared with lower social risk.ConclusionsDepressive and anxiety symptoms experienced by mothers in the initial weeks following VP birth can have long-term effects on their parenting behaviors. Enquiring about parents’ mental health during their child’s hospitalization in the neonatal intensive care unit is crucial.
One-anastomosis gastric bypass reversal due to severe malnutrition and acute hepatic failure: a case report
Authors: Verboonen Sotelo José Sergio , Romero Manzano Jeffry , Vega Tostado Guillermo , Guzmán Barba José Aldo , Esparza Estrada Isaac , Orozco Álvarez Malo José Oscar , González Ojeda Alejandro 
Published: January 2023

Abstract
The one-anastomosis gastric bypass (OAGB) is one of the most popular performed bariatric surgeries and has good long-term success for treating obesity and metabolic diseases. However, some patients can develop severe complications such as malnutrition and hepatic steatosis, which can be corrected with a reversal procedure, as seen in this case. A 20-year-old woman underwent OAGB surgery, which was converted to Roux-en-Y gastric bypass 4 months after the initial procedure due to malnutrition, both surgeries were performed at a hospital in southern Mexico. After the second surgery, she presented to our hospital with intolerance to oral feeding, vomiting and loss of 44 kg in 4 months. The patient was stabilized and scheduled for reversion surgery to normal anatomy 5 months later. She had good short-term nutritional outcomes and at the 1-year follow-up her total weight gain was 14 kg.
Metabolism along the life journey of T cells
Authors: Peng Min , Li Ming O 
Published: January 2023

Abstract
T cells are one of few cell types in adult mammals that can proliferate extensively and differentiate diversely upon stimulation, which serves as an excellent example to dissect the metabolic basis of cell fate decisions. During the last decade, there has been an explosion of research into the metabolic control of T-cell responses. The roles of common metabolic pathways, including glycolysis, lipid metabolism, and mitochondrial oxidative phosphorylation, in T-cell responses have been well characterized, and their mechanisms of action are starting to emerge. In this review, we present several considerations for T-cell metabolism-focused research, while providing an overview of the metabolic control of T-cell fate decisions during their life journey. We try to synthesize principles that explain the causal relationship between cellular metabolism and T-cell fate decision. We also discuss key unresolved questions and challenges in targeting T-cell metabolism to treat disease.
Constraining the physics of star formation from CIB-cosmic shear cross-correlations
Authors: Jego Baptiste , Alonso David , García-García Carlos , Ruiz-Zapatero Jaime 
Published: January 2023

ABSTRACT
Understanding the physics of star formation is one of the key problems facing modern astrophysics. The cosmic infrared background (CIB), sourced by the emission from all dusty star-forming galaxies since the epoch of reionization, is a complementary probe to study the star formation history, as well as an important extragalactic foreground for studies of the cosmic microwave background. In this paper, we make high signal-to-noise measurements of the cross-correlation between maps of the CIB from the Planck experiment, and cosmic shear measurements from the Dark Energy Survey and Kilo-Degree Survey. Cosmic shear is a direct tracer of the matter distribution and thus we can use its cross-correlation with the CIB to directly test our understanding of the link between the star formation rate (SFR) density and the matter density. We use our measurements to place constraints on a halo-based model of the SFR that parametrizes the efficiency with which gas is transformed into stars as a function of halo mass and redshift. These constraints are enhanced by using model-independent measurements of the bias-weighted SFR density extracted from the tomographic cross-correlation of galaxies and the CIB. We are able to place constraints on the peak efficiency at low redshifts, $\eta =0.445^{+0.055}_{-0.11}$, and on the halo mass at which this peak efficiency is achieved today log10(M1/M⊙) = 12.17 ± 0.25. Our constraints are in excellent agreement with direct measurements of the SFR density, as well as other CIB-based studies.
Tracing of magnetic fields with gradients: subsonic turbulence
Authors: Ho K W , Lazarian A 
Published: January 2023

ABSTRACT
The recent development of the velocity gradient technique shows the capability of the technique for tracing magnetic field morphology in diffuse interstellar gas and molecular clouds. In this paper, we perform a systematic numerical study of the performance of the velocity and synchrotron gradient for a wide range of magnetization in the subsonic environment. Addressing the studies of magnetic fields in atomic hydrogen, we also study the formation of velocity caustics in spectroscopic channel maps in the presence of thermal broadening. We show that the velocity caustics can be recovered when applied to the cold neutral medium and the gradient technique (GT) can reliably trace magnetic fields there. Finally, we discuss the changes in the anisotropy of observed structure functions when we apply to the analysis the procedures developed within the framework of GT studies.
From dark matter halos to pre-stellar cores: high resolution follow-up of cosmological Lyman–Werner simulations
Authors: Prole Lewis R , Schauer Anna T P , Clark Paul C , Glover Simon C O , Priestley Felix D , Klessen Ralf S 
Published: January 2023

ABSTRACT
Molecular hydrogen allows cooling in primordial gas, facilitating its collapse into Population III stars within primordial halos. Lyman–Werner (LW) radiation from these stars can escape the halo and delay further star formation by destroying H2 in other halos. As cosmological simulations show that increasing the background LW field strength increases the average halo mass required for star formation, we perform follow-up simulations of selected halos to investigate the knock-on effects this has on the Population III IMF. We follow 5 halos for each of the J21 = 0, 0.01, and 0.1 LW field strengths, resolving the pre-stellar core density of 10−6 g cm−3 (1018 cm−3) before inserting sink particles and following the fragmentation behaviour for hundreds of years further. We find that the mass accreted onto sinks by the end of the simulations is proportional to the mass within the ∼10−2 pc molecular core, which is not correlated to the initial mass of the halo. As such, the IMFs for masses above the brown dwarf limit show little dependence on the LW strength, although they do show variance in the number of low-mass clumps formed. As the range of background LW field strengths tested here covers the most likely values from literature, we conclude that the IMF for so-called Pop III.2 stars is not significantly different from the initial population of Pop III.1 stars. The primordial IMF therefore likely remains unchanged until the formation of the next generation of Population II stars.
The imprint of bursty star formation on alpha-element abundance patterns in Milky Way-like galaxies
Authors: Parul Hanna , Bailin Jeremy , Wetzel Andrew , Gurvich Alexander B , Faucher-Giguère Claude-André , Hafen Zachary , Stern Jonathan , Snaith Owain 
Published: January 2023

ABSTRACT
Milky Way-mass galaxies in the FIRE-2 simulations demonstrate two main modes of star formation. At high redshifts star formation occurs in a series of short and intense bursts, while at low redshifts star formation proceeds at a steady rate with a transition from one mode to another at times ranging from 3 to 7 Gyr ago for different galaxies. We analyse how the mode of star formation affects iron and alpha-element abundance. We find that the early bursty regime imprints a measurable pattern in stellar elemental abundances in the form of a ‘sideways chevron’ shape on the [Fe/H] – [O/Fe] plane and the scatter in [O/Fe] at a given stellar age is higher than when a galaxy is in the steady regime. That suggests that the evolution of [O/Fe] scatter with age provides an estimate of the end of the bursty phase. We investigate the feasibility of observing of this effect by adding mock observational errors to a simulated stellar survey and find that the transition between the bursty and steady phase should be detectable in the Milky Way, although larger observational uncertainties make the transition shallower. We apply our method to observations of the Milky Way from the Second APOKASC Catalogue and estimate that the transition to steady star formation in the Milky Way happened 7 – 8 Gyrs ago, earlier than transition times measured in the simulations.
Oxygen abundances in the narrow line regions of Seyfert galaxies and the metallicity–luminosity relation
Authors: Armah Mark , Riffel Rogério , Dors O L , Oh Kyuseok , Koss Michael J , Ricci Claudio , Trakhtenbrot Benny , Valerdi Mabel , Riffel Rogemar A , Krabbe Angela C 
Published: January 2023

ABSTRACT
We present oxygen abundances relative to hydrogen (O/H) in the narrow line regions (NLRs) gas phases of Seyferts 1 (Sy 1s) and Seyferts 2 (Sy 2s) active galactic nuclei (AGNs). We used fluxes of the optical narrow emission line intensities [$3\, 500\lt \lambda ($Å$)\lt 7\, 000$] of 561 Seyfert nuclei in the local Universe ( z ≲ 0.31) from the second catalogue and data release (DR2) of the BAT AGN Spectroscopic Survey, which focuses on the Swift-BAT hard X-ray (≳ 10 keV) detected AGNs. We derived O/H from relative intensities of the emission lines via the strong-line methods. We find that the AGN O/H abundances are related to their hosts stellar masses and that they follow a downward redshift evolution. The derived O/H together with the hard X-ray luminosity (LX) were used to study the X-ray luminosity–metallicity (LX–ZNLR) relation for the first time in Seyfert galaxies. In contrast to the broad-line focused (LX–ZBLR) studies, we find that the LX–ZNLR exhibit significant anticorrelations with the Eddington ratio (λEdd) and these correlations vary with redshifts. This result indicates that the low-luminous AGNs are more actively undergoing interstellar medium enrichment through star formation in comparison with the more luminous X-ray sources. Our results suggest that the AGN is somehow driving the galaxy chemical enrichment, as a result of the inflow of pristine gas that is diluting the metal rich gas, together with a recent cessation on the circumnuclear star-formation.
Estimating the feasibility of ‘standard speed-gun’ distances
Authors: Hodgson Jeffrey A , L’Huillier Benjamin , Liodakis Ioannis , Lee Sang-Sung , Shafieloo Arman 
Published: January 2023

ABSTRACT
In a previous paper, we demonstrated a single-rung method for measuring cosmological distances in active galactic nuclei (AGNs) that can be used from low redshift (z &lt; 0.1) to high redshift (z &gt; 3). This method relies on the assumption that the variability seen in AGNs is constrained by the speed of light during a flare event and can therefore be used to estimate the size of an emitting region. A limitation of this method is that previously, the Doppler factor was required to be known. In this paper, we derive an extension of the ‘standard speed-gun’ method for measuring cosmological distances that depends on the maximum intrinsic brightness temperature that a source can reach, rather than the Doppler factor. If the precise value of the intrinsic brightness temperature does not evolve with redshift, and flares are statistically independent, we can in principle improve the errors on measurements of the matter content of the Universe (in a flat Lambda cold dark matter model) statistically. We then explored how well a future observing programme would constrain cosmological parameters. We found that recovering the input cosmology depends critically on the uncertainty of the intrinsic brightness temperature and the number of flares observed.
The FANCC–FANCE–FANCF complex is evolutionarily conserved and regulates meiotic recombination
Authors: Singh Dipesh Kumar , Gamboa Rigel Salinas , Singh Avinash Kumar , Walkemeier Birgit , Van Leene Jelle , De Jaeger Geert , Siddiqi Imran , Guerois Raphael , Crismani Wayne , Mercier Raphael 
Published: January 2023

AbstractAt meiosis, programmed meiotic DNA double-strand breaks are repaired via homologous recombination, resulting in crossovers (COs). From a large excess of DNA double-strand breaks that are formed, only a small proportion gets converted into COs because of active mechanisms that restrict CO formation. The Fanconi anemia (FA) complex proteins AtFANCM, MHF1 and MHF2 were previously identified in a genetic screen as anti-CO factors that function during meiosis in Arabidopsis thaliana. Here, pursuing the same screen, we identify FANCC as a new anti-CO gene. FANCC was previously only identified in mammals because of low primary sequence conservation. We show that FANCC, and its physical interaction with FANCE–FANCF, is conserved from vertebrates to plants. Further, we show that FANCC, together with its subcomplex partners FANCE and FANCF, regulates meiotic recombination. Mutations of any of these three genes partially rescues CO-defective mutants, which is particularly marked in female meiosis. Functional loss of FANCC, FANCE, or FANCF results in synthetic meiotic catastrophe with the pro-CO factor MUS81. This work reveals that FANCC is conserved outside mammals and has an anti-CO role during meiosis together with FANCE and FANCF.