bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gadolinium (III)‐Chelated Deformable Mesoporous Organosilica Nanoparticles as Magnetic Resonance Imaging Contrast Agent
Authors: Chen Xiangyu , Teng Shiyong , Li Jinming , Qiao Xuezhi , Zhao Weidong , Xue Zhengjie , Shi Xudong , Wang Yuguang , Yang Wensheng , Wang Tie 
Published: March 2023

AbstractMagnetic resonance imaging (MRI) contrast agents, such as Magnevist (Gd‐DTPA), are routinely used for detecting tumors at an early stage. However, the rapid clearance by the kidney of Gd‐DTPA leads to short blood circulation time, which limits further improvement of the contrast between tumorous and normal tissue. Inspired by the deformability of red blood cells, which improves their blood circulation, this work fabricates a novel MRI contrast agent by incorporating Gd‐DTPA into deformable mesoporous organosilica nanoparticles (D‐MON). In vivo distribution shows that the novel contrast agent is able to depress rapid clearance by the liver and spleen, and the mean residence time is 20 h longer than Gd‐DTPA. Tumor MRI studies demonstrated that the D‐MON‐based contrast agent is highly enriched in the tumor tissue and achieves prolonged high‐contrast imaging. D‐MON significantly improves the performance of clinical contrast agent Gd‐DTPA, exhibiting good potential in clinical applications.
Advances in Electrochemical Sensors for Detecting Analytes in Biofluids
Authors: Lee Jimin , Kim Myung Chul , Soltis Ira , Lee Sung Hoon , Yeo Woon‐Hong 
Published: March 2023

AbstractMore than half of all Americans suffer from chronic diseases, the leading causes of death and disability. However, prompt treatment of chronic diseases can lead to better patient outcomes and a reduced burden on the healthcare system. This highlights the urgent need for electrochemical (EC) sensors that provide non‐invasive, real‐time monitoring of disease‐indicating biomarkers. Due to their high sensitivity, high selectivity, and cost‐effectiveness, EC biosensors have recently shown tremendous promise for individualized health monitoring. This review explains the working principles of EC biosensors. It summarizes the recent advances and improvements of EC biosensors for detecting biomarkers in different biofluids, including tears, saliva, breath, urine, and sweat. Through a comprehensive overview of EC biosensor technologies, this article is expected to aid the development of flexible and wearable EC biosensing systems that have the potential to provide continuous, long‐term health monitoring for both clinical and at‐home use.
Can a sustainability facts label reduce the halo surrounding organic labels?
Authors: Neuhofer Zachary T. , Lusk Jayson L. , Villas‐Boas Sofia 
Published: March 2023

AbstractConsumers often form beliefs about credence attributes unsupported by the best available evidence. In particular, prior research has revealed many consumers have overly‐optimistic beliefs about the environmental and nutritional impacts of organic food. We propose and study the effects of a sustainability facts label (SFL), which displays quantitative environmental information related to global warming potential, land use, and energy use per serving size of the product. The SFL is akin to a nutrition facts label (NFL), which we also study. We surveyed a nationally representative sample of milk consumers in the United States (USA) to measure their choices and beliefs about organic vs. conventional milk under one of three different label information treatments; the NFL only, the SFL only, and both labels relative to a control without any nutrition or sustainability information. Unexpectedly, our results show that the SFL increased the likelihood of organic purchases. Facts panels altered beliefs; The participants exposed to the SFL increased their perception that organic performs better on environmental metrics, despite the fact the information contained in the label provided a nuanced picture with organic better in some dimensions and worse in others. Consistent with the information provided, consumers exposed to the NFL decreased their perception that organic had fewer calories and more protein than conventional milk. Prior beliefs about organic were found to be important determinants of choice and information acquisition.
High response rates and transition to transplant after novel targeted and cellular therapies in adults with relapsed/refractory acute lymphoblastic leukemia with Philadelphia‐like fusions
Authors: Aldoss Ibrahim , Afkhami Michelle , Yang Dongyun , Gu Zhaohui , Mokhtari Sally , Shahani Shilpa , Pourhassan Hoda , Agrawal Vaibhav , Koller Paul , Arslan Shukaib , Tomasian Vanina , Al Malki Monzr M. , Artz Andrew , Salhotra Amandeep , Ali Haris , Aribi Ahmed , Sandhu Karamjeet S. , Ball Brian , Otoukesh Salman , Amanam Idoroenyi , Becker Pamela S. , Stewart Forrest M. , Curtin Peter , Smith Eileen , Telatar Milhan , Stein Anthony S. , Marcucci Guido , Forman Stephen J. , Nakamura Ryotaro , Pullarkat Vinod 
Published: March 2023

AbstractPhiladelphia (Ph)‐like acute lymphoblastic leukemia (ALL) is associated with a poor response to standard chemotherapy. However, outcomes with novel antibody and cellular therapies in relapsed/refractory (r/r) Ph‐like ALL are largely unknown. We conducted a single‐center retrospective analysis of adult patients (n = 96) with r/r B‐ALL and fusions associated with Ph‐like who received novel salvage therapies. Patients were treated with 149 individual novel regimens (blinatumomab = 83, inotuzumab ozogamicin [InO] = 36, and CD19CAR T cells = 30). The median age at first novel salvage therapy was 36 years (range; 18–71). Ph‐like fusions were IGH::CRLF2 (n = 48), P2RY8::CRLF2 (n = 26), JAK2 (n = 9), ABL‐class (n = 8), EPOR::IGH (n = 4) and ETV6::NTRK2 (n = 1). CD19CAR T cells were administered later in the course of therapy compared to blinatumomab and InO (p < .001) and more frequently in recipients who relapsed after allogeneic hematopoietic cell transplantation (alloHCT) (p = .002). Blinatumomab was administered at an older age compared to InO and CAR T‐cells (p = .004). The complete remission (CR)/CR with incomplete hematologic recovery (CRi) rates were 63%, 72%, and 90% following blinatumomab, InO and CD19CAR, respectively, among which 50%, 50%, and 44% of responders underwent consolidation with alloHCT, respectively. In multivariable analysis, the type of novel therapy (p = .044) and pretreatment marrow blasts (p = .006) predicted the CR/CRi rate, while the Ph‐like fusion subtype (p = .016), pretreatment marrow blasts (p = .022) and post‐response consolidation with alloHCT (p < .001) influenced event‐free survival. In conclusion, novel therapies are effective in inducing high remission rates in patients with r/r Ph‐like ALL and successfully transitioning the responders to alloHCT.
Multitargeted Platinum(IV) Anticancer Complexes Bearing Pyridinyl Ligands as Axial Leaving Groups
Authors: Zhou Qiyuan , Chen Shu , Xu Zoufeng , Liu Gongyuan , Zhang Shuyuan , Wang Zhigang , Tse Man‐Kit , Yiu Shek‐Man , Zhu Guangyu 
Published: March 2023

AbstractAlthough multitargeted PtIV anticancer prodrugs have shown significant activities in reducing drug resistance, the types of bioactive ligands and drugs that can be conjugated to the Pt center remain limited to O‐donors. Herein, we report the synthesis of PtIV complexes bearing axial pyridines via ligand exchange reactions. Unexpectedly, the axial pyridines are quickly released after reduction, indicating their potential to be utilized as axial leaving groups. We further expand our synthetic approach to obtaining two multitargeted PtIV prodrugs containing bioactive pyridinyl ligands: a PARP inhibitor and an EGFR tyrosine kinase inhibitor; these conjugates exhibit great potential for overcoming drug resistance, and the latter conjugate inhibits the growth of Pt‐resistant tumor in vivo. This research adds to the array of synthetic methods for accessing PtIV prodrugs and significantly increases the types of bioactive axial ligands that can be conjugated to a PtIV center.
Muscle architecture of the hindlimb of Tyto furcata (Aves Strigiformes): Highlights in owl morphology
Authors: Tudisca Alejandro M. , Mosto Clelia , Picasso Mariana B. J. 
Published: March 2023

AbstractThe American barn owl is a nocturnal bird of prey in which hind limb movements are a key factor in obtaining food; however, the architectural properties of its hind limb muscles have not been studied. This study sought to identify functional trends in the Tyto furcata hindlimb muscles by studying muscular architecture. The architectural parameters of the selected hip, knee, ankle, and digit muscles were studied in three specimens of the Tyto furcata and joint muscular proportions with an additional dataset were calculated. Previously published information on Asio otus was used for comparison. The flexor muscles of the digits had the highest muscle mass. Regarding architectural parameters, the main flexor of the digits (flexor digitorum longus) and the muscles that extend the knee and ankle joints (femorotibialis and gastrocnemius) showed a high physiological cross‐sectional area (PCSA) and short fibers, allowing powerful digit flexion and knee and ankle extension. These mentioned features are in accordance with hunting behavior, in which prey capture is not only closely linked to the flexion of the digits but also to the movements of the ankle. During hunting, the distal hind limb is flexed and then fully extended at the moment of contact with the prey, whereas the digits are close to grasping the prey. The hip muscles showed a predominance of extensors over flexors, which were more massive, with parallel fibers and without tendons or short fibers. These features lead to a higher capacity to generate velocity to the detriment of forces, as indicated by the high values of the architectural index, their relatively low PCSA, and short or intermediate fiber length, which enhance the control of the joint positions and muscle length. Compared to Asio otus, Tyto furcata showed longer fibers; however, the relationship between fiber length and PCSA was similar for both species.
A statistical study on promoting effects of tropical cyclones over the Bay of Bengal on the South China Sea summer monsoon onset
Authors: Fan Xiaoting , Li Ying 
Published: March 2023

AbstractThe onset date of the South China Sea (SCS) summer monsoon (SCSSM) and the generation time of the first tropical cyclone (TC) over the Bay of Bengal (BoB) during late April and early June were significantly correlated with a correlation coefficient of 0.58 during 1979–2020. The composite analysis found that under the impact of BoB TCs, an enhanced southwesterly low‐level flow transported abundant moisture from the BoB to the northern SCS. Besides, the diabatic heating related to TC convection stimulated an anticyclonic anomaly in the upper troposphere over the southern Tibetan Plateau, which was conducive to the enhancement and expansion of the South Asian high (SAH) over the Indo‐China Peninsula. The stronger easterly outflows from the eastern periphery of the SAH overlapped with low‐level water vapor convergence over the northern SCS, enhancing the development of monsoon convection. Thus, more condensation heating warmed the tropospheric atmosphere and reversed the meridional temperature gradient over the SCS, implying the SCSSM onset.
Study of the microstructure of brain white matter in medial temporal lobe epilepsy based on diffusion tensor imaging
Authors: Zhang Yiwei , Liu Zhaoxi , Dou Wanchen , Wei Juan , Lv Yuelei , Hou Bo , You Hui , Feng Feng 
Published: March 2023

AbstractObjectivesTo compare the white matter (WM) asymmetry in left and right medial temporal lobe epilepsy (mTLE) with and without hippocampal sclerosis (HS+, HS–) and assess the correlation of preoperative asymmetry and the dynamics of WM fibers with surgical outcomes.Materials and methodsPreoperative MRI scans were collected from 58 mTLE patients (40 HS+, 18 HS–); 15 (11 HS+, 4 HS–) then underwent postoperative MRI scans. DTI parameters, including the fractional anisotropy (FA), mean diffusion coefficient (MD), axial diffusion coefficient (AD), and radial diffusion coefficient (RD), were extracted from 20 paired WM tracts by PANDA based on the JHU WM tractography atlas. The bilateral cerebral parameters and the pre‐ to postoperative changes in the DTI parameters of specific fiber tracts were compared. The asymmetry indexes (AIs) of paired fibers were also analyzed.ResultsThere were fewer asymmetrical WM fibers in HS– patients than in HS+ patients. The pattern of WM asymmetry differed between left and right mTLE patients. Differences in the FA AI of the inferior fronto‐occipital fasciculus and inferior longitudinal fasciculus (ILF) were found in left HS+ patients with different surgical outcomes. All mTLE patients exhibited decreases in FA and increases in MD and RD in specific ipsilateral WM fibers. In International League Against Epilepsy (ILAE) grade 1 patients, the MD values in the ipsilateral CGH increased over time, whereas the RD values in the ipsilateral ILF and the AD values in the ipsilateral ILF and UNC decreased. In ILAE grade 2–5 patients, the FA values in the ipsilateral cingulate gyrus part of the cingulum (CGC) increased over time.ConclusionThe WM tract asymmetry was more extensive in HS+ patients than in HS– patients. The preoperative WM fiber AIs in left HS+ patients may be useful for surgical prognosis. Additionally, pre‐ to postoperative changes in WM fibers may help predict surgical outcomes.
The senile plaque: Morphological differences in APP knock‐in mice brains by fixatives
Authors: Yoshimura Rikuya , Miyasaka Tomohiro , Funamoto Satoru , Saito Takashi , Saido Takaomi C. , Ikegawa Masaya , Kakuda Nobuto 
Published: March 2023

AbstractThe morphology of senile plaques depends on the APP knock‐in mice brain fixative. Solid forms of senile plaques were detected in APP knock‐in mice after formic acid treatment with Davidson's and Bouin's fluid fixative as the brain of AD patients. Aβ42 was deposited as cored plaques and Aβ38 accumulated around Aβ42.
Mental health symptoms among those affected by Huntington's disease: A cross‐sectional study
Authors: Gunn Sarah , Dale Maria , Ovaska‐Stafford Noora , Maltby John 
Published: March 2023

AbstractBackgroundAlthough cognitive and motor symptoms of Huntington's disease (HD) are associated with disease progression, the underlying causes of psychological symptoms are not as clearly understood. Recent evidence suggests that some mental health difficulties experienced by people with HD are shared by noncarriers within HD families. Accordingly, there is a need to evaluate potential systemic contributors to HD mental distress, to support meaningful interventions for psychological symptoms in people with HD and affected families.MethodWe used short‐form Problem Behaviors Assessment mental health symptom data from the international Enroll‐HD data set to characterize mental health symptoms across eight HD groups: Stages 1–5, premanifest and genotype‐negative individuals, and family controls (n = 8567) using chi‐square analysis with post hoc comparisons.ResultsWe identified that people with later‐stage HD (Stages 2–5) had significantly higher apathy, obsessive–compulsiveness, and (from Stage 3) disorientation than the remaining groups at a medium effect size, and that these findings largely held across three measure administrations over time.ConclusionsThese findings highlight the critical symptoms in manifest HD from Stage 2 onward, but also demonstrate that crucial symptoms such as depression, anxiety, and irritability are present across HD‐affected groups (including noncarriers of the gene expansion). The outcomes highlight a need for specific clinical management of later‐stage HD psychological symptoms, and for systemic support across affected families.
Association between telomere length and hepatocellular carcinoma risk: A Mendelian randomization study
Authors: Yang Chenglei , Wu Xi , Chen Siyu , Xiang Bangde 
Published: March 2023

AbstractBackgroundHepatocellular carcinoma (HCC) is a common cancer threatening the public health globally. Although HCC has been associated with the telomere length (TL), the causal relationship between them is not well understood. Therefore, we attempted to explore the linear causal relationship between TL and HCC through Mendelian randomization (MR) analysis among Asian and European populations.MethodsThe summary statistics of TL‐associated single nucleotide polymorphisms (SNPs) were obtained from a genome‐wide association study (GWAS) in the Asian population (N = 23,096). The data of TL‐associated SNPs in the European population (N = 472,174) and the GWAS summary statistics of HCC in the Asian population (1866 cases, 195,745 controls) as well as the European population (168 cases, 372,016 controls) were downloaded from the public GWAS database. Two‐sample MR was performed using inverse variance weighting (IVW), weighted median estimate, MR–Egger regression, weighted‐mode estimate, and simple‐mode estimate methods. Sensitivity analysis was performed to text the primary results' robustness.ResultsNine SNPs associated with TL in Asian populations and 98 SNPs in European populations were selected as instrumental variables. No linear causal relationship between heritable TL and the HCC risk was recorded in the Asian (IVW analysis odds ratio [OR] = 1.023, 95% confidence interval [CI] 0.745, 1.405, p = 0.887) and European populations (IVW analysis OR = 0.487, 95% CI 0.180, 1.320, p = 0.157). Other methods also achieved similar outcomes. Sensitivity analysis was performed and revealed no heterogeneity and horizontal pleiotropy.ConclusionsNo linear causal association was recorded between heritable TL and HCC in Asian and European populations.
Planning for return to work during the first year after breast cancer metastasis: A Swedish cohort study
Authors: Johnsson Aina , Kiani Narsis A. , Gernaat Sofie A. M. , Wilking Ulla , Shabo Ivan , Hedayati Elham 
Published: March 2023

AbstractBackgroundPlanning for return to work (RTW) is relevant among sub‐groups of metastatic breast cancer (mBC) survivors. RTW and protective factors for RTW in patients with mBC were determined.MethodsPatients with mBC, ages 18–63 years, were identified in Swedish registers, and data were collected starting 1 year before their mBC diagnosis. The prevalence of working net days (WNDs) (>90 and >180) during the year after mBC diagnosis (y1) was determined. Factors associated with RTW were assessed using regression analysis. The impact of contemporary oncological treatment of mBC on RTW and 5‐year mBC‐specific survival was compared between those diagnosed in 1997–2002 and 2003–2011.ResultsOf 490 patients, 239 (48.8%) and 189 (36.8%) had >90 and >180 WNDs, respectively, during y1. Adjusted odds ratios (AORs) of WNDs >90 or >180 during y1 were significantly higher for patients with age ≤50 years (AOR180 = 1.54), synchronous metastasis (AOR90 = 1.68, AOR180 = 1.67), metastasis within 24 months (AOR180 = 1.51), soft tissue, visceral, brain as first metastatic site (AOR90 = 1.47) and sickness absence <90 net days in the year before mBC diagnosis, suggesting limited comorbidities (AOR90 = 1.28, AOR180 = 2.00), respectively. Mean (standard deviation) WNDs were 134.9 (140.1) and 161.3 (152.4) for patients diagnosed with mBC in 1997–2002 and 2003–2011, respectively (p = 0.046). Median (standard error) mBC‐specific survivals were 41.0 (2.5) and 62.0 (9.6) months for patients diagnosed with mBC in 1997–2002 and 2003–2011, respectively (p < 0.001).ConclusionsRTW of more than 180 WNDs was associated with younger age, early development of metastases and limited comorbidities during the year before the diagnosis of mBC. Patients diagnosed with mBC in 2003 or later had more WNDs and better survival than those diagnosed earlier.
Sulfotransferase 1C2 promotes hepatocellular carcinoma progression by enhancing glycolysis and fatty acid metabolism
Authors: Jiang Liya , Xu Fang , Li Chenglong , Liu Ting , Zhao Qianwei , Liu Yixian , Zhao Ying , Li Yamei , Zhang Zhendong , Tang Xiaolei , Zhang Jintao 
Published: March 2023

AbstractBackgroundHepatocellular carcinoma (HCC) is aggressive liver cancer. Despite advanced imaging and other diagnostic measures, HCC in a significant portion of patients had reached the advanced stage at the first diagnosis. Unfortunately, there is no cure for advanced HCC. As a result, HCC is still a leading cause of cancer death, and there is a pressing need for new diagnostic markers and therapeutic targets.MethodsWe investigated sulfotransferase 1C2 (SUTL1C2), which we recently showed was overexpressed in human HCC cancerous tissues. Specifically, we analyzed the effects of SULT1C2 knockdown on the growth, survival, migration, and invasiveness of two HCC cell lines, i.e., HepG2 and Huh7 cells. We also studied the transcriptomes and metabolomes in the two HCC cell lines before and after SULT1C2 knockdown. Based on the transcriptome and metabolome data, we further investigated the SULT1C2 knockdown‐mediated shared changes, i.e., glycolysis and fatty acid metabolism, in the two HCC cell lines. Finally, we performed rescue experiments to determine whether the inhibitory effects of SULT1C2 knockdown could be rescued via overexpression.ResultsWe showed that SULT1C2 overexpression promoted the growth, survival, migration, and invasiveness of HCC cells. In addition, SULT1C2 knockdown resulted in a wide range of gene expression and metabolome changes in HCC cells. Moreover, analysis of shared alterations showed that SULT1C2 knockdown significantly suppressed glycolysis and fatty acid metabolism, which could be rescued via SULT1C2 overexpression.ConclusionsOur data suggest that SULT1C2 is a potential diagnostic marker and therapeutic target for human HCC.
Obesity in children and adolescents: Overview of the diagnosis and management
Authors: Tung Joanna Y. L. , Poon Grace W. K. , Du Juan , Wong Kenneth K. Y. 
Published: March 2023

AbstractChildhood obesity is one of the biggest public health challenges globally. It is associated with various adverse health consequences throughout life. Prevention and early intervention represent the most reasonable and cost‐effective approaches. Considerable progress has been achieved in the management of obesity in children and adolescents; yet, implementation in the real world remains a challenge. This article aimed to present an overview of the diagnosis and management of obesity in children and adolescents.