bluuebunny/crossref_metadata_2025_split huggingface dataset:
COVID-19 and persistent inflammation, immunosuppression and catabolism syndrome
Authors: TATLISULUOĞLU Derya , TURAN Güldem 
Published: July 2023

Purpose: Multiple organ failure (MOF) is a disease group that necessitates intensive care monitoring and carries a significant mortality rate. If these individuals are not dead as a result of early MOF, they will either quickly restore immunological balance or their immunological dysfunction may persist, resulting in chronic critical illness (CCI). Some of these patients have CCI, which is characterized by chronic inflammation, immunosuppression, and the syndrome of catabolism (PICS). With this study, we aimed to evaluate PICS cases in our intensive care unit, their effects on mortality, and their biomarkers.
Materials and Methods: This is a retrospective, observational study involving 190 patients diagnosed with acute respiratory distress syndrome (ARDS) due to SARS-CoV-2 and followed up in the ICU. Patients' laboratory data and body mass index (BMI) were compared between the first and twenty-first days of ICU admission. In addition, the patients were evaluated according to PICS utilizing the number of days they spent in the ICU, CRP, albumin, prealbumin, lymphocytes, and BMI data.
Results: The laboratory values of the patients on the 21st day were as follows, and the results obtained were statistically significant when compared with the values on the 1st day. Albumin 2.56±0.57 g/L, prealbumin 9±15 g/L, d-dimer 4.41±4.70 (interquartile range (IQR): 2.53-4.76) µgFEU/mL, fibrinogen 497±189,35 mg/dl, hemoglobin 10.15±1.82 g/dL, leukocytes 13.94±8.12 (IQR: 12.34-7.69) 109/L, immature granulocyte 1.16±2.13 (IQR: 0.46-1)109/L and BMI of 26.92±3.27 (IQR: 26.7-4.8). Again in these patients, lymphocyte values were 0.92±0.80 (IQR: 0.71-0.74)109/L, CRP was 101.42±99,96 mg/L, and platelet values were 214.24±128.08 109/L.
Conclusion: PICS is a significant condition affecting mortality and morbidity in critical care patients. In this group of patients, immature granulocytes may also serve as a useful biomarker. Due to the lack of studies regarding PICS, we are in the premature phase of understanding the pathogenesis and management of PICS and therefore need more comprehensive research regarding the topic.
Effects of herbal mixture on burned rat skin infected with Pseudomonas aeruginosa
Authors: YİĞİT Serdar , GEZER Arzu , BALKAN BOZLAK Çiğdem Eda , ÇELİK Seda , BİNGÖL Seyit Ali 
Published: July 2023

Purpose: The purpose of this study is to investigate the healing impact of an ointment derived from the Alkanna tinctoria plant upon Pseudomonas aeruginosa-induced infections.
Material and Methods: In this study, 18 male adolescent rats (mean age 6 weeks) weighed an average of 180 g were used. Animals were divided into 3 groups. Group 1: Control group (consisting of burns, no treatment was done), Group 2 (P. aeruginosa): Burn was created and infected with P. aeruginosa, Group 3 (Cream): P. aeruginosa was used to infect the burns area and the herbal mixture was administered twice a day, once in the morning and once in the afternoon. Under anesthesia, the backs of the rats were shaved, and a specially produced steel bar with a diameter of 1*1 cm was immersed in boiling water for 15 seconds before being applied to their backs for 20 seconds. The burned area was subsequently infected with the ATCC Pseudomonas aeruginosa strain, and samples were collected 24 hours later. To detect bacterial growth in this area, the samples were inoculated on blood and EMB (Eosin Methylene Blue) media in a microbiology laboratory. After inoculation, the animals were placed in separate sterile cages and randomly divided into three groups. Once the growth was observed, the tissue and blood samples were harvested from the rats on the 2nd, 7th, 14th, and 21st days.
Results: Epithelial regeneration in this group was more prominent. Vascularization was remarkable on the 2nd day, especially in the group in where we induced a burn and applied the ointment. VEGF levels increased more in the ointment group than in that of others. On the 2nd day of the study, the average bacterial count was 105 in sample of both 2nd and 3rd groups. At the end of the study, while the average of bacterial count was increased in the 2nd group, the average of bacterial count was decreased in the 3rd group.
Conclusion: It was concluded that the ointment obtained from A. tinctorial successfully repaired the epithelial tissue and contributed to the healing of wounds by modifying increasing VEGF in the blood. However, further research is needed before this ointment can be highly recommended for therapeutic usage
Factors affecting the false negativity of fine-needle aspiration biopsy in thyroid nodules with indeterminate cytology
Authors: ÖZEMİR İbrahim Ali 
Published: July 2023

Purpose: False negative results of fine needle aspiration biopsies (FNAB) remain one of the most important problems in the management of thyroid nodules. The aim of this study was to evaluate the factors affecting the false negative results of FNAB, especially in thyroid nodules with indeterminate cytology.
Materials and Methods: Patients with thyroid nodules who underwent FNAB and subsequent thyroidectomy between January 2017 and January 2020 were included in the study. FNAB was performed on suspicious nodules according to the TIRADS classification. Nodules with "atypia/follicular lesion of undetermined significance (AUS/FLUS)", "non-diagnostic (ND)" cytology or "follicular neoplasm/suspicious for follicular neoplasm (FN/SFN)" according to FNAB were defined as "indeterminate cytology (IC)". Nodules were analyzed in two groups. Nodules with false negative FNAB were included in Group-1, while nodules with true positive and true negative FNAB were included in Group-2. Demographic and clinical data, pathologic results and genetic profiles of the patients were statistically compared for all patients and IC group separately.
Results: The results of FNAB and final pathology were discordant in 94 patients (Group-1) and concordant in 233 patients (Group-2). In the IC subgroup, 56 of 95 patients were in IC/Group-1 and 39 patients were in IC/Group-2. The accuracy of FNAB was statistically significantly higher in the presence of extrathyroidal extension (71.4% vs. 30.8%), perineural/lymphovascular invasion (60.0% vs. 29.6%), classical variants (68.5% vs. 50.7%), non-encapsulated tumors (67.9% vs. 50.0%) and multicentricity (47.2% vs. 24.1%). In the IC group, the presence of thyroiditis (75.0% vs. 49.2%) and high serum Anti-TPO levels (60.0% vs. 30.7%) increased the rate of false negativity on FNAB. High serum Neutrophil to Lymphocyte Ratio (NLR) and small tumor size also increase the false negativity of FNAB, especially in IC group patients.
Conclusion: The diagnostic accuracy of FNAB is increased in classical variant tumors and in tumors expected to be aggressive due to presence of extra-thyroidal extension, perineural/lymphovascular invasion, non-encapsulated tumors and multicentricity. It should be kept in mind that the false negative results of FNAB increase in the presence of thyroiditis, high level of serum anti-TPO and high level of NLR.
Evaluation of demographic, clinical characteristics and cost of immigrant patients with end-stage renal failure
Authors: TELAFARLI Mehmet Ali , ÇAKIR Adem 
Published: July 2023

Purpose: Due to wars and disasters, people migrate forcibly due to their need for safe housing and health care. In our study, we aimed to the demographic and clinical typical of immigrants with end-stage renal disease and to make a cost analysis.
Materials and Methods: Our study is single-center and retrospective. Migrant patients who have end-stage renal disease who met the study criteria were included in the study. Demographic data, clinical data, laboratory data and treatment cost data of the cases were added to the previously created form.
Results: Our study was conducted with 696 patients. 64.2% of the cases were female and the median age was 67 years. 65.5% of the cases were of Syrian nationality. Hemodialysis was applied to all of the cases, of which 47% were urgently. 55.2% of these cases were hospitalized and mortality was observed in 13.2% of all cases. Age was statistically higher in cases with mortality. Urea and creatinine in patients with mortality were significantly higher; pH, HCO3 and GFR were statistically lower. Mortality was statistically higher in cases requiring urgent hemodialysis and hospitalized in the ICU. The cost of health was statistically higher in surviving cases. Again, in patients who were hospitalized, both the time allocated for care and the cost of health were statistically higher than in outpatients.
Conclusion: Establishing routine dialysis programs by identifying immigrant cases with end-stage renal disease will both reduce mortality and morbidity for patients, reduce health costs in countries, and reduce emergency department densities.
Effect of serum adropin levels on circulating endothelial dysfunction biomarkers in COVID-19 patients
Authors: GÜNEŞAÇAR Ramazan , DEMİR EKŞİ Durkadın , ALPAY Ali Seydi , HANİKOĞLU Ferhat , ERDOĞAN Haluk 
Published: July 2023

Purpose: Several studies show that the symptoms of severe COVID-19 infection reflect the clinical phenotype of endothelial dysfunction and share common pathophysiological mechanisms with endothelial dysfunction. Therefore, the aim of the study was to investigate the effect of serum adropin levels on endothelial dysfunction biomarkers and determine whether adropin could be a new biomarker for COVID-19.
Materials and Methods: The study included 40 patients with mild/moderate COVID-19, 48 patients with severe/critical COVID-19, and 37 controls. Serum adropin and circulating biomarkers of endothelial dysfunction including asymmetric dimethylarginine (ADMA), endothelin-1 (ET-1), endothelial nitric oxide synthase (eNOS), soluble intercellular adhesion molecule-1 (sICAM-1) and plasminogen activator inhibitor-1 (PAI-1) levels were determined by micro-ELISA.
Results: Serum adropin levels were found to be significantly higher in COVID-19 patients (165.2±11.49 pg/ml) than in controls (85.46±12.08 pg/ml). Serum adropin levels of patients with severe/critical symptoms (194±16.23 pg/ml) were significantly higher than the patients with mild/moderate symptoms (130.6 ±14.53). In addition, serum ADMA, eNOS, and, ET-1 levels were significantly higher in the COVID-19 subjects (150.5±8.67 ng/ml, 172.4±14.01 pg/ml, 159.3±10.19 pg/ml, respectively) than that those in the controls (104.5±9.182 ng/ml, 141.4±17.74 pg/ml, 100.1±11.37 pg/ml, respectively). Significant positive correlations were found between adropin and ADMA, eNOS, ET-1, sICAM-1, and PAI-1 levels in the patients.
Conclusion: We suggest that adropin may be a new potential biomarker for COVID-19 and an important molecule in restoring endothelial cell damage. Positive correlations between serum adropin levels and ADMA, eNOS, ET-1, sICAM-1 and PAI-1 levels in patients suggest that adropin may compensate for damage to endothelial cells.
Implementación de BITCOIN en El Salvador
Authors: Garay Rodríguez Andrya Miriam 
Published: July 2023

Septiembre 7 de 2021 en El Salvador adopto el BITCOIN está criptomoneda como moneda de curso legal con el fin de facilitar la inclusión financiera e impulsar el crecimiento económico, por lo que el presente articulo busca analizar el uso BITCOIN en las micro y pequeñas empresas en el desarrollo de sus transacciones comerciales ante el establecimiento de esta moneda. Para ello se realiza un estudio cualitativo mediante encuestas a 133 empresas definidas en un muestreo no probabilístico por conveniencia, a fin de obtener información acerca del uso del BITCOIN en su implementación como moneda de curso legal que permitiera identificar su posicionamiento de las empresas con esta estrategia. En las empresas encuestadas, se determina el bajo nivel de aceptación en el uso del BITCOIN, para cobrar o pagar en la realización de sus operaciones comerciales y aquellos empresarios que la aceptaban lo retenían en la billetera de Chivo emitida en el Gobierno en Dólares. La mayoría de los negocios manifiestan que no han percibido un beneficio como efecto en la implementación del BITCOIN. El BITCOIN como moneda de curso legal se estableció en El Salvador como una medida de inclusión financiera, donde 40,00% de las personas tienen acceso a una cuenta bancaria, pero el desconocimiento de funcionamiento de las criptomonedas ha llevado a que no la acepten en su uso, lo que presenta un reto de formación. La inclusión financiera no debe hacerse desvinculada de mecanismos de alfabetización financiera para que cumpla sus objetivos de uso, acceso, calidad y bienestar, donde el mostrar a las poblaciones vulnerables los beneficios y riesgos de los distintos productos entre ellos las Criptomonedas se vuelven relevantes para su implementación.
Comprometidos con la renovación de la acreditación del programa de Contaduría Pública de la Universidad Libre, seccional Barranquilla
Authors: Jiménez Castro Joaquin 
Published: July 2023

En agosto de este año se recibirá la visita de los pares académicos del Consejo Nacional de Acreditación, CNA, con miras a la renovación de la acreditación del programa de Contaduría Pública. Simultáneamente, el programa de Administración de Negocios Internacionales se viene preparando para someterse a la acreditación de alta calidad. Este reto lo asumió un equipo de docentes, administrativos y directivos de la Facultad CEAC, comprometidos con altos niveles de exigencia para garantizar la calidad del programa, cuya fortaleza está en la formación de sus líderes, quienes guían los esfuerzos de la comunidad académica hacia las metas de los objetivos de desarrollo sostenible, respetando la identidad cultural de la región y el país.
Acorde a la visión de nuestra Alma Mater, el programa de Contaduría Pública busca fortalecer la solución pacifista del entorno en el que se encuentran inmersos los estudiantes y egresados, promoviendo su liderazgo y el mejoramiento continuo de los procesos contables, económicos y administrativos. Este programa cuenta con el marco legal de la International Federation of Accountants (IFAC) y del Institute Management Accountant, en el ámbito internacional, y con el marco Legal Nacional de la Junta Central de Contadores, el Consejo Técnico de la Contaduría y la Contaduría General de la Nación.
La Universidad pretende que sus Contadores Públicos estén capacitados para manejar las normas internacionales de información financiera y el aseguramiento de la información financiera (NIIF y NIIA, en su orden). Es decir, que no sólo se busca el desarrollo de las competencias cuantitativas de la formación contable, sino que se fortalece su interpretación. Se busca desarrollar las habilidades humanas del profesional contable ante el inminente reto que representa la inteligencia artificial.
Effect of matrix rhythm therapy on pain, disability, and quality of life among patient with frozen shoulder
Authors: Chamola Sunil Kumar , Kanuja  , Chamola Yogesh , Mohapatra S C 
Published: July 2023

Frozen shoulder also known as adhesive capsulitis is a condition that causes pain and stiffness in the shoulder joint. It occurs when the tissues in the shoulder joint become thick and stiff and making it difficult to move the shoulder. It is an experimental design conducted in SGT medical college amongst 40 to 60 years population in the department of physiotherapy collaborative to the department of community medicine. To investigate the impact of Matrix Rhythm Therapy on shoulder joint discomfort, restricted ROM, and quality of life. There were three scale used NPRS, SPADI and WHOQL. It was observed that in comparison of conventional group the experimental group was more significant with highly effective results. Shoulder pain was common in today’s perspective due to cause of change in lifestyle and quality of life.
Increased preanalytical errors during Covid-19 Pandemic
Authors: Tyagi Surbhi 
Published: July 2023

The clinical laboratories worldwide have faced numerous obstacles due to the COVID-19 pandemic. In the midst of this outbreak, mistakes that occur during the preanalytical phase of sample collection, transportation, and processing can result in unfavorable clinical outcomes. Therefore, the aim of this investigation was to ascertain and contrast the rate at which blood specimens are rejected by a clinical laboratory and to analyze and compare the types of preanalytical errors during the pre-pandemic and pandemic periods. The present retrospective study was done in Chhatrapati Shivaji Subharti Hospital; India. Information was gathered from two distinct time periods - the pre-pandemic phase, which spanned from December 30th, 2019 to March 22, 2020, and the pandemic phase, which ran from March 23th to November 30, 2020. The rate of rejection for blood samples was established by determining the percentage of blood collection tubes containing preanalytical mistakes out of the total number of tubes received. A total of 102,000 blood samples were examined, out of which 40,800 (40%) were collected during the pandemic. The pandemic phase witnessed a significantly higher rate of rejection of blood samples (4%) as compared to the pre-pandemic phase (1%) (P &#60; 0.001). In both phases, the most common preanalytical error was the clotting of samples. There was a significant increase in improperly labeled samples during the pandemic, while there was a notable decrease in hemolyzed samples. Given the prevailing situation of the Corona pandemic, altered logistics have led to a significant surge in preanalytical errors and consequent rejection of blood specimens in clinical laboratories. Therefore, it is imperative to take corrective measures at different levels to minimize preanalytical errors, which would ultimately enhance patient care and optimize the utilization of resources.
The Limits of Liberalism. Tradition, Individualism, and the crisis of freedom, Mark. T. Mitchell, University of Notre Dame Press, Indiana 2019, ss. 328 – Artykuł Recenzyjny
Authors: Dzięcioł Mateusz 
Published: July 2023

Mark T. Mitchell w recenzowanej pracy prezentuje model krytyki liberalizmu. Punktem wyjścia dla jego argumentacji jest obserwacja Michaela Polanyiego, zgodnie z którą źródła politycznego i duchowego kryzysu stanowią rezultat przyjęcia błędnej koncepcji wiedzy. Uniemożliwia ona formułowanie sensownych twierdzeń na temat kategorii, które utożsamia się z triadą platońską: prawdą, dobrem i pięknem. Autor korzysta też z argumentów religijnych. W toku swojego wywodu stwierdza, że człowiek potrzebuje łaski Boga, by przezwyciężyć swoją niedoskonałość, która stanowi immanen- tną część ludzkiej natury.
Wartość erudycyjna publikacji jest trudna do przecenienia, a propozycja rozumienia tradycji w kategoriach epistemicznych i uczynienia z niej fundamentu dla konstrukcji nowego porządku społeczno-politycznego stanowi kwestię wartą poddania szerszej dyskusji. Widoczne są jednak pewne braki metodologiczne: niekompletność rekonstrukcji prezentowanych stanowisk, brak rozróżnień terminologicznych, które mogą powodować konfuzję znaczeniową oraz dyskusyjność przyjmowanych założeń. Książkę Mitchella należy więc postrzegać wielowymiarowo.
Religious Moderation Reflected on Students' Digital Comic: A Speech Act Analysis
Authors: Yanottama Fourica , Optara Kusuma Andhika , Hidayatulloh Aris 
Published: July 2023

This study discusses speech acts in Digital Comic discourse created by UIN Raden Mas Said Surakarta students who are members of the Creative Digital Skills Development Class. The comic discourse campaigns for the importance of tolerance both from religion and fellow human beings. By using Searle's theory, analysis of speech acts in discourse is carried out. Searle provides further categories of illocutionary speech acts into representative, directive, commissive, expressive, and declarative categories. These categories make it easier for researchers to see the specific meaning in question.
The data from this study emphasize the utterances uttered by the main comic characters. In addition, images from data become secondary data from this study because discourse consists of two units, namely text (verbal) and images (non-verbal). The data is processed and classified into several speech act classifications proposed by Searle. Data is described by qualitative methods.
The results of this study indicate that the speech acts reflected from digital comics by UIN Raden Mas Said Surakarta students have topics that refer to tolerance and maintaining harmony between religious communities or among people. From the 15 data, there are directive, expressive, and representative speech acts with dominant directive speech acts. The results show that the use of directive speech acts is the main and most effective reference in conveying the moral message of invitation, namely the invitation to maintain harmony. While expressive speech acts are used as speech acts that reflect empathy for others. In this case, it is the empathy between friends or religion.
English Learners Speaking Performance: Do Self-Perception and Exteroception Influence Their Language Acquisition?
Authors: Liani Silva , Hamid Radiah 
Published: July 2023

The research aimed to find out how students’ perception and its’ influence toward students’ speaking performance. There were two types of perception recorded, namely self-perception and exteroception. Self-perception is a perception that is formed based on internal factors or from within , while exteroception is a perception that is formed based on external factors or from outside of a person . The research methodology used was quantitative research. The data obtained using two instruments, namely close-ended questionnaire and students’ speaking performance score. The data were analysed through Multiple Linear Regression Analysis . The results of data analysis from 46 samples found that 1) Students’ self-perception (72.09) and exteroception (67.85) categorized as good perception, 2) Simultaneously, self-perception and exteroception has significance influence toward speaking performance (F-test 8.73 > F-table 4.07). 3) Self-perception has significance influence toward speaking performance (T-test 2.347 > T-table 2.014), and Exteroception has no significance influence toward speaking performance (T-test 0.590 < T-table 2.014). Therefore, it can be concluded that students’ self-perception has the higher score than students’ exteroception. Simultaneously, both them were have significance influence toward speaking performance, while partially self-perception was the only variable has significance influence toward speaking performance. The needs and desires of students toward speaking were dominated positively. They need English speaking for their future career, which indirectly becomes motivation in speaking class.