bluuebunny/crossref_metadata_2025_split huggingface dataset:
Resolución del problema integrado de enrutamiento y gestión de inventarios con múltiples vehículos mediante programación lineal entera mixta
Authors: Hincapié-Londoño Frank Alejandro , García-Guevara Jhonatan Stiven , Toro-Ocampo Eliana Mirledy 
Published: July 2023

Contexto: El control y distribución de inventarios son procesos claves en la pérdida tanto de eficiencia como de eficacia en el campo de la logística, a nivel global. Según el Departamento Nacional de Planeación de Colombia, en el año 2020, los rubros de transporte, almacenamiento e inventarios correspondieron al 73,9 % del costo logístico total. La resolución del problema de enrutamiento inventario con múltiples vehículos (IRP) representa una alternativa para hacer que los tiempos de ciclo sean más cortos, más flexibles y menos costosos.
Método: En este artículo se describen y comparan modelos matemáticos de la literatura para el problema base, adaptándolo a su variante con múltiples vehículos y resolviéndolo a través modelos de programación lineal entera mixta, mediante la solución de instancias de baja y media complejidad matemática, planteando dos maneras de gestionar el inventario y tres formas de eliminar la creación de sub-tours. Para obtener los resultados se utiliza el software AMPL en un computador con procesador Intel Core i5-5200U CPU @ 2.2 GHz y 4 GB de RAM, considerando un tiempo máximo de ejecución de una hora.
Resultados: El modelo de flujos muestra el mejor desempeño en cuanto a tiempos computacionales y calidad de la respuesta con respecto a la política de máximo nivel (ML), y la variante MTZ es el segundo mejor modelo. Por último, la variación general reporta mayores tiempos de ejecución y valores GAP más altos. Los modelos presentan buen desempeño para instancias de pequeño y mediano tamaño.
Conclusiones: En esta investigación se presenta una metodología general que puede ser adaptada a diferentes aplicaciones del problema integrado de inventarios y enrutamiento con múltiples vehículos. Se comprobó que las respuestas generadas son de buena calidad, destacando la eliminación de sub-tours por medio del modelo de flujos y la gestión de inventarios bajo la política ML. Los trabajos futuros deben encaminarse en busca de nuevas alternativas a la optimización exacta, tales como las heurísticas o metaheurísticas, que permitan estar lo más cerca posible del óptimo en tiempos de computación más cortos. Además, se podrían considerar demandas estocásticas y el manejo de productos perecederos, entre otros.
Rapid response redevelopment: a study of an English-to-Chinese translation course moving online
Authors: Cook Angela , Dianati Seb , Spinelli Franciele , Lai Yen-Ying 
Published: July 2023

Abstract
In early 2020, the tertiary sector in Australia, as in many other parts of the world, was confronted with a series of unforeseen challenges arising from the coronavirus epidemic. As governments responded to the crisis by implementing increasingly strict social distancing and isolation measures, universities had little choice but to adapt their courses for online delivery. The ensuing chaos and confusion prompted academics and support staff to adapt quickly to changing delivery while continuing to offer high-quality teaching and learning experiences. This mixed-methods study explores the approaches that were adopted in a translation course that moved fully online and examines students’ engagement with and evaluation of the new course design. The findings reveal that it is possible to maintain high levels of student satisfaction by ensuring a clearly structured course design in an online mode with interactive and engaging course materials. This has implications for university lecturers wishing to redesign courses in an online or blended format, especially under time pressure.
Comparison of performance for third order immune photonic transmission link incorporating phase shifters and biased optimized dual parallel Mach–Zehnder modulator
Authors: Berwal Pulkit , Singh Sarika 
Published: July 2023

Abstract
This paper presents a comprehension on the linearization arrangements achieved through dual drive dual parallel Mach–Zehnder (DD-DPMZM) by changing bias voltages of sub-modulators and adjusting phases of RF signals. These arrangements comprise of a DD-DPMZM and electric phase shifters. For single sideband (SSB) modulation in sub-modulators of DD-DPMZM, power at intermodulation is found to be 43 dB and 61 dB for the linearized and convention single modulator link respectively. Thus, 28 dB of improvement in suppression of third order intermodulation distortion is reported for the first arrangement of linearization. For quadrature modulation in upper MZM and optical carrier suppression (OCS) modulation in lower modulator, almost complete suppression of IMD3 terms are demonstrated and found to be better performance arrangement for bias optimized dual parallel Mach–Zehnder modulator based linearization link.
Performance evaluation of a currently in-use dry storage cask design for spent accident tolerant fuel loading case under normal operation condition
Authors: Durdu Habibe Merve , Bulut Acar Banu 
Published: July 2023

Abstract
The aim of this study is to assess the performance of an existing dry storage cask design for accident tolerant fuel loading case and to examine the compliance with the safety limits applied currently for dry storage. In the study, for a dry storage cask design currently in use, criticality calculations, dose rate evaluation and thermal analyses are performed in case of loading with the accident tolerant fuel discharged from a PWR. Firstly, for an accident tolerant fuel selected among the concepts proposed for use in light water reactors, burnup analyses are performed by utilizing the Serpent continuous energy code and spent fuel characteristics are determined. Then, criticality analyzes are carried out by using the Serpent Monte Carlo code for the case of loading the accident tolerant fuel into the selected dry storage cask design. Gamma and neutron dose rates at the outer surface and close distances of the storage cask are determined with the Serpent code. To evaluate the thermal performance of the storage cask, thermal analyzes are performed by using the ANSYS Fluent computational fluid dynamics code. The analysis results are compared with the nuclear safety criteria applied to dry storage casks. Results of the analysis show that the dry storage cask design currently in-use does not exceed the criticality, dose rate and maximum surface temperature limits when loaded with spent accident tolerant fuel.
Long non-coding RNA GNAS-AS1 knockdown inhibits proliferation and epithelial–mesenchymal transition of lung adenocarcinoma cells via the microRNA-433-3p/Rab3A axis
Authors: He Jing , Xi Xiaoxiang , Cao Peng , Zhou Jinxia , Liu Hui , Li Na 
Published: July 2023

Abstract
The goal of this study was to demonstrate the functions and specific mechanism of long non-coding RNA (lncRNA) GNAS-AS1 in lung adenocarcinoma. Levels of lncRNA GNAS-AS1, microRNA (miR)-433-3p, and Rab3A were assessed by quantitative real-time PCR (qRT-PCR). The target-binding sites of lncRNA GNAS-AS1, miR-433-3p, and Rab3A were predicted and confirmed by bioinformatics tool (StarBase) and a dual-luciferase reporter system. Cell proliferation and apoptosis were checked using MTT and flow cytometry, respectively. Additionally, the levels of apoptosis-related and epithelial–mesenchymal transition (EMT)-associated genes in A549 cells were analyzed by qRT-PCR and western blot. We found that lncRNA GNAS-AS1 was upregulated, miR-433-3p was low-expressed, and Rab3A was overexpressed in lung adenocarcinoma tissues and cell lines. LncRNA GNAS-AS1 interacted with miR-433-3p and negatively regulated miR-433-3p levels. Rab3A was a direct target of miR-433-3p. Downregulation of lncRNA GNAS-AS1 remarkably suppressed cell proliferation, promoted cell apoptosis, decreased B-cell lymphoma-2 (Bcl-2) expression, enhanced the Bcl-2-Associated X (Bax) level, promoted E-cadherin expression, and reduced N-cadherin and Rab3A levels. However, the miR-433-3p inhibitor reversed all these findings. Similarly, the inhibitory effects of miR-433-3p mimic on A549 cells were reversed by the Rab3A-plasmid. In conclusion, lncRNA GNAS-AS1 downregulation suppressed lung adenocarcinoma cell proliferation and EMT through the miR-433-3p/Rab3A axis.
Physicochemical stability of durvalumab (Imfinzi®) concentrate for solution in original vials after first opening
Authors: Almasi Jannik , Thiesen Judith , Krämer Irene 
Published: July 2023

Abstract

Objectives
Durvalumab (Imfinzi®), a PD-L1 monoclonal antibody (mAb) medication is available as concentrate (50 mg/mL) for solution for infusion. The summary of product characteristics provides information about the physicochemical stability of ready-to-administer durvalumab preparations (vehicle solution 0.9 % NaCl, G5%), but not about the concentrate after first opening. The objective of this study was to determine the physicochemical stability of durvalumab concentrate for solution after first opening over a period of 28 days.

Methods
Imfinzi® vials were punctured and stored refrigerated (2–8 °C) or at room temperature (20–25 °C) light protected. At predefined time points (day 0, 7, 14, 21, 28) the physicochemical stability of the concentrated solution was determined by ion-exchange/size-exclusion high-performance liquid chromatography (IE-/SE-HPLC) with photodiode array detection and pH measurement. Vials were inspected with regard to changes of color, clarity, and visible particles at any time point.

Results
Regardless of the storage temperature, durvalumab 50 mg/mL solutions remained physiochemically stable for 28 days in punctured vials. The concentrations of durvalumab monomer remained unchanged and no secondary peaks (fragments, aggregates) were observed in any of the SE-HPLC chromatograms. The IE-HPLC test results showed no substantial changes of the peak areas of the main peak and of the acidic and basic charge variants during the whole storage period. Appearance and pH of the test solutions remained unchanged until the end of the study.

Conclusions
Regardless of storage conditions none of the analytical methods indicated physicochemical instability of the intact durvalumab monomer over the 28 days of the study. To avoid microbiological instability storage under refrigeration is recommended.
Data management of process plants as complex systems: systematic literature review and identification of challenges and opportunities
Authors: Layer Max , Leidich Jonathan , Schwoch Sebastian , Saske Bernhard , Neubert Sebastian , Robl Peter , Paetzold-Byhain Kristin 
Published: July 2023

Abstract
Led by the manufacturing industry, virtual replicas of production systems also known as digital twins (DTs) are gradually moving into all areas of industry. Their advantages are characterized by the possibility of product optimization, simulations, improved monitoring and prediction of downtimes and optimized maintenance, to name just a few. The engineering, procurement and construction (EPC) of process plants as mechatronic systems is characterized by a high degree of project-specific modifications and interdisciplinary engineering effort with low reusability, in contrast to unit-production-driven areas such as automotive. This results in a high cost-benefit ratio for the creation of DTs over the life cycle of process plants, especially when suppliers are integrated into the value chain. The objective of this paper is to analyze the state of plant lifecycle management, data exchange and the possibilities of optimized supplier integration during the planning and EPC of process plants regarding DT creation and usage. Three research questions (RQs) were used to narrow down a total of 356 identified publications to 54, which were then examined. The papers covered a variety of topics, including combining discipline-specific models, plant management approaches and the combination of both.
Atticist Lexica and the Interpretation of Comic Language
Authors: Monaco Chiara 
Published: July 2023

Abstract
This study aims to analyse how Atticist lexicographers used ancient sources to problematize their lack of sensitivity to literary contexts. This article focuses on comic passages that are interpreted according to the prescriptive outlook of Atticist lexicographers. I will show how lexicographers’ notes on linguistic correctness betray a general indifference towards the stylistic registers and complex variety of the language of comedy. Two case studies will be investigated: (a) the backdating of koine words and (b) the misinterpretation of comic corrections. The analysis of these two cases shows that lexicographers very often interpreted comic attestations as evidence of regular Greek expressions if this reading served the purpose of censoring or supporting a specific usage, regardless of whether or not the comedians were using a word metaphorically or in a jocular way.
Lucus a non lucendo: Enantiosemy in Ancient Latin Lexicography
Authors: Gitner Adam 
Published: July 2023

AbstractEnantiosemes, words which express opposed meanings (also called auto-antonyms; e.g.altus, which can mean “high” or “low”, or the English “cleave”, which can mean “cut” or “stick together”), present a practical problem for the lexicographer. My paper surveys enantiosemes as they are explicitly discussed by ancient Roman lexicographers and provides a descriptive typology. Roman scholars distinguish between genuine auto-antonyms, which they sometimes callvoces mediae(e.g.valetudofor “health” or “sickness”), and cases of etymology by antiphrasis (e.g.lucus a non lucendo), whereby a name is given through some kind of opposition. This latter group of etymologies-by-antiphrasis can be further subdivided between cases of euphemism and irony. The paper concludes with a short lexicon of Latin enantiosemes explicitly discussed by ancient sources.
An Ongoing Supplement to Traditional Dictionaries:

WiP –

Words in Progress

and the Contribution of Greek Documentary Papyrology
Authors: D’Angelo Marzia 
Published: July 2023

Abstract
Greek lexicography is in a state of constant evolution thanks to progress in philological studies and, in a special way, to the contribution offered by papyri, which frequently provides us with new words or new meanings of already known words. In this regard, the online, freely consultable database WiP – Words in Progress. Supplementary Lexicon of Ancient Greek aims to collect new or rare words and detail corrections and additions in order to record recent progress in the updating and expansion of Ancient and Byzantine Greek. This contribution aims to describe how the database works, and what advantages it offers compared to traditional dictionaries, with a particular focus on the contribution that Greek documentary papyri offer to Greek lexicography.
Adaptation Shapes Local Cortical Reactivity: From Bifurcation Diagram and Simulations to Human Physiological and Pathological Responses
Authors: Cattani Anna , Galluzzi Andrea , Fecchio Matteo , Pigorini Andrea , Mattia Maurizio , Massimini Marcello 
Published: July 2023

AbstractHuman studies employing intracerebral and transcranial perturbations suggest that the input-output properties of cortical circuits are dramatically affected during sleep in healthy subjects as well as in awake patients with multifocal and focal brain injury. In all these conditions, cortical circuits react to direct stimulation with an initial activation followed by suppression of activity (Off-period) that disrupts the build-up of sustained causal interactions typically observed in healthy wakefulness. The transition to this stereotypical response has important clinical implications, being associated with loss of consciousness or loss of functions. Here, we provide a mechanistic explanation of these findings by means of simulations of a cortical-like module endowed with activity-dependent adaptation and mean-field theory. First, we show that fundamental aspects of the local responses elicited in humans by direct cortical stimulation can be replicated by systematically varying the relationships between adaptation strength and excitation level in the network. Then, we reveal a region in the adaptation-excitation parameter space of crucial relevance for both physiological and pathologic conditions, where spontaneous activity and responses to perturbation diverge in their ability to reveal Off-periods. Finally, we substantiate through simulations of connected cortical-like modules the role of adaptation mechanisms in preventing cortical neurons from engaging in reciprocal causal interactions, as suggested by empirical studies. These modeling results provide a general theoretical framework and a mechanistic interpretation for a body of neurophysiological measurements that bears critical relevance for physiological states as well as for the assessment and rehabilitation of brain-injured patients.
Parabrachial Nucleus Activity in Nociception and Pain in Awake Mice
Authors: Smith Jesse A. , Ji Yadong , Lorsung Rebecca , Breault Macauley S. , Koenig Jeffrey , Cramer Nathan , Masri Radi , Keller Asaf 
Published: July 2023

The parabrachial nuclear complex (PBN) is a nexus for aversion and for the sensory and affective components of pain perception. We have previously shown that during chronic pain PBN neurons in anesthetized rodents have amplified activity. We report a method to record from PBN neurons of behaving, head-restrained mice while applying reproducible noxious stimuli. We find that both spontaneous and evoked activity are higher in awake animals compared with urethane anesthetized mice. Fiber photometry of calcium responses from calcitonin-gene-related peptide–expressing PBN neurons demonstrates that these neurons respond to noxious stimuli. In both males and females with neuropathic or inflammatory pain, responses of PBN neurons remain amplified for at least 5 weeks, in parallel with increased pain metrics. We also show that PBN neurons can be rapidly conditioned to respond to innocuous stimuli after pairing with noxious stimuli. Finally, we demonstrate that changes in PBN neuronal activity are correlated with changes in arousal, measured as changes in pupil area.SIGNIFICANCE STATEMENTThe parabrachial complex is a nexus of aversion, including pain. We report a method to record from parabrachial nucleus neurons of behaving mice while applying reproducible noxious stimuli. This allowed us to track parabrachial activity over time in animals with neuropathic or inflammatory pain. It also allowed us to show that the activity of these neurons correlates with arousal states and that these neurons can be conditioned to respond to innocuous stimuli.
Antimicrobial and Immunomodulatory Action of Probiotic Composition of Bacilli on Bacterial Vaginitis in Mice
Authors: Lazarenko L.M. , Babenko L.P. , Safronova L.A. , Demchenko O.M. , Bila V.V. , Zaitseva G.M. , Spivak M.Ya. 
Published: July 2023

The purpose of this study was to investigate the antimicrobial and immunomodulatory action of a probiotic composition of Bacillus subtilis and B. megatherium strains (UnicaUro, Sirion (Ukraine)) for experimental bacterial vaginitis. Methods. Experimental studies were conducted on female BALB/c mice; we used Staphylococcus aureus strain B-918 (ATCC 6538) to induce bacterial vaginitis. The strain was vaginally introduced into mice before treatment with probiotic bacteria. In the vagina of mice, aerobic and optionally anaerobic bacteria, including representatives of the genera Staphylococcus, Streptococcus, Lactobacillus, Bifidobacterium, Pseudomonas, coliform bacteria, and microscopic fungi were identified in different periods of observation using generally accepted microbiological methods. Serum antibody titer to S. aureus was determined by the bacterial agglutination reaction. The phagocytic activity and oxygen-dependent bactericidal activity of peritoneal exudate macrophages (PEM) were evaluated using generally accepted immunological methods. Results. The formation of bacterial vaginitis in the BALB/c mice line infected with S. aureus B-918 (ATCC 6538) was evidenced by the appearance of external clinical manifestations of the infectious and inflammatory process against the background of the increased number of aerobic and optionally anaerobic microorganisms, including representatives of the genus Staphylococcus and Streptococcus, microscopic fungi, and decreased number of lactobacilli in different observation periods. The probiotic introduction to mice with bacterial vaginitis led to a dynamic change in the vaginal microbiota: the number of aerobic and optionally anaerobic microorganisms decreased, primarily due to the normalization of the number of representatives of Staphylococcus genus accompanied by a decrease in the antibody titer to staphylococcus in the blood serum. The effective therapeutic action of the probiotic was confirmed by the gradual disappearance of the external clinical signs of the infectious-inflammatory process in the vagina against the background of the functional activity of PEM. Conclusions. The probiotic composition of B. subtilis and B. megatherium (UnicaUro, Sirion, Ukraine) is a promising antimicrobial formulation that may be used in the treatment of bacterial vaginitis; however, further studies are required to confirm its therapeutic, antimicrobial, and immunomodulatory efficacy.
Update on treatment studies for compulsive buying-shopping disorder: A systematic review
Authors: Müller Astrid , Laskowski Nora M. , Thomas Tobias A. , Antons Stephanie , Tahmassebi Nadja , Steins-Loeber Sabine , Brand Matthias , Georgiadou Ekaterini 
Published: July 2023

AbstractBackground and aimsCompulsive buying-shopping disorder (CBSD) is mentioned as an example of other specified impulse control disorders in the ICD-11 coding tool, highlighting its clinical relevance and need for treatment. The aim of the present work was to provide a systematic update on treatment studies for CBSD, with a particular focus on online CBSD.MethodThe preregistered systematic review (PROSPERO, CRD42021257379) was performed in accordance with the PRISMA 2020 statement. A literature search was conducted using the PubMed, Scopus, Web of Science and PsycInfo databases. Original research published between January 2000 and December 2022 was included. Risk of reporting bias was evaluated with the CONSORT guideline for randomized controlled trials. Effect sizes for primary CBSD outcomes were calculated.ResultsThirteen studies were included (psychotherapy: 2 open, 4 waitlist control design; medication: 2 open, 3 placebo-controlled, 2 open-label phase followed by a double-blind discontinuation phase; participants treatment/control 349/149). None of the studies addressed online CBSD. Psychotherapy studies suggest that group cognitive-behavioral therapy is effective in reducing CBSD symptoms. Pharmacological studies with selective serotonin re-uptake inhibitors or topiramate did not indicate superiority over placebo. Predictors of treatment outcome were rarely examined, mechanisms of change were not studied at all. Risk of reporting bias was high in most studies.DiscussionPoor methodological and low quality of reporting of included studies reduce the reliability of conclusions. There is a lack of studies targeting online CBSD. More high-quality treatment research is needed with more emphasis on the CBSD subtype and mechanisms of change.