bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chinese expert consensus on the diagnosis and treatment of malignant pleural mesothelioma
Authors: Wang Qian , Xu Chunwei , Wang Wenxian , Zhang Yongchang , Li Ziming , Song Zhengbo , Wang Jiandong , Yu Jinpu , Liu Jingjing , Zhang Shirong , Cai Xiuyu , Li Wen , Zhan Ping , Liu Hongbing , Lv Tangfeng , Miao Liyun , Min Lingfeng , Li Jiancheng , Liu Baogang , Yuan Jingping , Jiang Zhansheng , Lin Gen , Chen Xiaohui , Pu Xingxiang , Rao Chuangzhou , Lv Dongqing , Yu Zongyang , Li Xiaoyan , Tang Chuanhao , Zhou Chengzhi , Zhang Junping , Guo Hui , Chu Qian , Meng Rui , Liu Xuewen , Wu Jingxun , Hu Xiao , Zhou Jin , Zhu Zhengfei , Chen Xiaofeng , Pan Weiwei , Pang Fei , Zhang Wenpan , Jian Qijie , Wang Kai , Wang Liping , Zhu Youcai , Yang Guocai , Lin Xinqing , Cai Jing , Feng Huijing , Wang Lin , Du Yingying , Yao Wang , Shi Xuefei , Niu Xiaomin , Yuan Dongmei , Yao Yanwen , Huang Jianhui , Wang Xiaomin , Zhang Yinbin , Sun Pingli , Wang Hong , Ye Mingxiang , Wang Dong , Wang Zhaofeng , Hao Yue , Wang Zhen , Wan Bing , Lv Donglai , Yu Jianwei , Kang Jin , Zhang Jiatao , Zhang Chao , Wu Lixin , Shi Lin , Ye Leiguang , Wang Gaoming , Wang Yina , Gao Feng , Huang Jianfei , Wang Guifang , Wei Jianguo , Huang Long , Li Bihui , Zhang Zhang , Li Zhongwu , Liu Yueping , Li Yuan , Liu Zhefeng , Yang Nong , Wu Lin , Wang Qiming , Huang Wenbin , Hong Zhuan , Wang Guansong , Qu Fengli , Fang Meiyu , Fang Yong , Zhu Xixu , Du Kaiqi , Ji Jiansong , Shen Yi , Chen Jing , Zhang Yiping , Ma Shenglin , Lu Yuanzhi , Song Yong , Liu Anwen , Zhong Wenzhao , Fang Wenfeng 
Published: July 2023

AbstractMalignant pleural mesothelioma (MPM) is a malignant tumor originating from the pleura, and its incidence has been increasing in recent years. Due to the insidious onset and strong local invasiveness of MPM, most patients are diagnosed in the late stage and early screening and treatment for high‐risk populations are crucial. The treatment of MPM mainly includes surgery, chemotherapy, and radiotherapy. Immunotherapy and electric field therapy have also been applied, leading to further improvements in patient survival. The Mesothelioma Group of the Yangtze River Delta Lung Cancer Cooperation Group (East China LUng caNcer Group, ECLUNG; Youth Committee) developed a national consensus on the clinical diagnosis and treatment of MPM based on existing clinical research evidence and the opinions of national experts. This consensus aims to promote the homogenization and standardization of MPM diagnosis and treatment in China, covering epidemiology, diagnosis, treatment, and follow‐up.
Production similarity and the cross‐section of stock returns: A machine learning approach
Authors: Ge Yao , Qiao Zheng , Shen Zhe , Zhang Zhiyu 
Published: July 2023

AbstractThis paper employs a machine learning approach to capture firm‐pair production similarity, which depicts how firms' production processes resemble each other using textual data in corporate MD&As. We show that production‐linked firms' average return has strong predictive power on focal firm's future stock return. A hedging portfolio yields an annualised return of 11.69%, which cannot be subsumed by existing factor models. For mechanism tests, we find that the main findings are stronger in firms with higher information asymmetry and higher costs of arbitrage. The production‐linkage measure also predicts future unexpected earnings, suggesting it possibly includes valuable information on firm fundamentals.
Robot‐assisted versus three‐dimensional laparoscopic radical prostatectomy: 12‐month outcomes of a randomised controlled trial
Authors: Haapiainen Henry , Murtola Teemu J. , Koskimäki Juha , Riikonen Jarno , Pakarainen Tomi , Haney Caelán M. , Raitanen Mika , Kaipia Antti 
Published: July 2023

ObjectivesTo compare functional and oncological outcomes of robot‐assisted laparoscopic prostatectomy (RALP) to three‐dimensional laparoscopic radical prostatectomy (3D‐LRP) at 12 months after surgery.Patients and methodsProspective randomised single‐centre study of 145 consecutive men referred to radical prostatectomy in a tertiary referral centre in Finland. Patients were randomised 1:1 to the RALP (N = 75) and 3D‐LRP (N = 70) groups. The primary outcome was urinary continence evaluated with the Expanded Prostate Cancer Index Composite 26‐item version (EPIC‐26) incontinence domain score at 12 months after surgery. Secondary outcomes included the use of protective pads at 12 months after surgery, EPIC‐26 domain scores of irritative/obstructive, bowel, sexual and hormonal symptoms, positive surgical margin (PSM) rate, and biochemical recurrence (BCR). Complication frequency within the 3‐month period after surgery was evaluated according to Clavien–Dindo classification. Statistical significance between groups was analysed using Mann–Whitney, chi‐square and Fisher's exact tests. The trial was terminated after interim analysis based on no statistically significant difference in EPIC‐26 urinary incontinence domain scores. Altogether 145 patients of the target accrual of 280 patients were recruited.ResultsPostoperative continence at 12 months after surgery according to the EPIC‐26 incontinence domain was 79.25 in both groups (P = 0.4). Between group difference was −5.8 (95% confidence interval –15.2 to 3.6). There was no statistically significant difference in the rates of PSM or BCR between the two surgical modality groups.ConclusionWe were unable to demonstrate a difference between the RALP and 3D‐LRP groups for functional and oncological outcomes at 12 months after surgery.
International Society of Urological Pathology (ISUP) Gleason Grade Groups stratify outcomes in the CHHiP Phase 3 prostate radiotherapy trial
Authors: Dearnaley David , Griffin Clare L. , Silva Pedro , Wilkins Anna , Stuttle Christine , Syndikus Isabel , Hassan Shama , Pugh Julia , Cruickshank Clare , Hall Emma , Corbishley Catherine M. 
Published: July 2023

ObjectivesTo compare the results of Gleason Grade Group (GGG) classification following central pathology review with previous local pathology assessment, and to examine the difference between using overall and worst GGG in a large patient cohort treated with radiotherapy and short‐course hormone therapy.Patients and MethodsPatients with low‐ to high‐risk localized prostate cancer were randomized into the multicentre CHHiP fractionation trial between 2002 and 2011. Patients received short‐course hormone therapy (≤6 month) and radical intensity‐modulated radiotherapy (IMRT). Of 2749 consented patients, 1875 had adequate diagnostic biopsy tissue for blinded central pathology review. The median follow‐up was 9.3 years. Agreement between local pathology and central pathology‐derived GGG and between central pathology‐derived overall and worst GGG was assessed using kappa (κ) statistics. Multivariate Cox regression and Kaplan–Meier methods were used to compare the biochemical/clinical failure (BCF) and distant metastases (DM) outcomes of patients with GGG 1–5.ResultsThere was poor agreement between local pathology‐ and central pathology‐derived GGG (κ = 0.19) but good agreement between overall and worst GGG on central pathology review (κ = 0.89). Central pathology‐derived GGG stratified BCF and DM outcomes better than local pathology, while overall and worst GGG on central pathology review performed similarly. GGG 3 segregated with GGG 4 for BCF, with BCF‐free rates of 90%, 82%, 74%, 71% and 58% for GGGs 1–5, respectively, at 8 years when assessed using overall GGG. There was a progressive decrease in DM‐free rates from 98%, 96%, 92%, 88% and 83% for GGGs 1–5, respectively, at 8 years with overall GGG. Patients (n = 57) who were upgraded from GGG 2–3 using worst GS had BCF‐free and DM‐free rates of 74% and 92% at 8 years. CHHiP eligibility criteria limit the interpretation of these results.ConclusionContemporary review of International Society of Urological Pathology GGG successfully stratified patients treated with short‐course hormone therapy and IMRT with regard to both BCF‐free and DM‐free outcomes. Patients upgraded from GGG 2 to GGG 3 using worst biopsy GS segregate with GGG 3 on long‐term follow‐up. We recommend that both overall and worst GS be used to derive GGG.
Novel Tu translation elongation factor, mitochondrial (TUFM) homozygous variant in a consanguineous family with premature ovarian insufficiency
Authors: Zhang Jun , Zhou Xing‐Yu , Wang Ao , Lai Yun‐Hui , Zhang Xiao‐Fei , Liu Xiao‐Tong , Wang Zhe , Liu Yu‐Dong , Tang Shu‐Yan , Chen Shi‐Ling 
Published: July 2023

AbstractPremature ovarian insufficiency (POI) is a clinical syndrome of ovarian dysfunction characterized by cessation of menstruation occurring before the age of 40 years. The genetic causes of idiopathic POI remain unclear. Here we recruited a POI patient from a consanguineous family to screen for potential pathogenic variants associated with POI. Genetic variants of the pedigree were screened using whole‐exome sequencing analysis and validated through direct Sanger sequencing. A homozygous variant in TUFM (c.524G>C: p.Gly175Ala) was identified in this family. TUFM (Tu translation elongation factor, mitochondrial) is a nuclear‐encoded mitochondrial protein translation elongation factor that plays a critical role in maintaining normal mitochondrial function. The variant position was highly conserved among species and predicted to be disease causing. Our in vitro functional studies demonstrated that this variant causes decreased TUFM protein expression, leading to mitochondrial dysfunction and impaired autophagy activation. Moreover, we found that mice with targeted Tufm variant recapitulated the phenotypes of human POI. Thus, this is the first report of a homozygous pathogenic TUFM variant in POI. Our findings highlighted the essential role of mitochondrial genes in folliculogenesis and ovarian function maintenance.
The clinical efficacy of autogenous dentin blocks prepared chairside for alveolar ridge augmentation: A systematic review and meta‐analysis
Authors: Mahardawi Basel , Kyaw Thiha Tin , Mattheos Nikos , Pimkhaokham Atiphan 
Published: July 2023

AbstractObjectivesThis systematic review aimed to evaluate the current evidence on the effectiveness of autogenous dentin block graft prepared chairside for alveolar ridge augmentation and compare its clinical outcomes to the main available grafting materials and techniques.Materials and MethodsThree databases were screened, including prospective clinical studies, utilizing autogenous dentin blocks for ridge augmentation, with at least 3 months of postoperative follow‐up.ResultsEight articles were included, and four of them were meta‐analyzed. Dentin blocks demonstrated similar vertical bone gain and significantly higher width gain, compared to bone blocks (WMD = 0.03, 95% CI −0.51 to 0.57, p = .92 and WMD = 1.34, 95% CI 0.57 to 2.12, p = .0007, respectively). Vertical and horizontal resorption were similar between the two groups (WMD = −0.36, 95% CI −0.91 to 0.18, p = .19, and WMD = −0.47, 95% CI −1.05 to 0.11, p = .11, respectively). Dentin blocks showed more incidences of postoperative complications, however, with no statistical significance (RR = 4.30, 95% CI 0.97 to 18.96, p = .054). The need for additional augmentation upon implant placement was also similar between both grafts (RR = 0.95, 95% CI 0.39 to 2.28, p = .90). Recorded incidences of graft exposure were low (2.27%), and no study stated surgical site infection.ConclusionWithin its limitations, this study indicates that the autogenous dentin blocks prepared chairside could be a possible alternative to the other established bone augmentation techniques for staged ridge augmentation. Nevertheless, future studies are needed to confirm its efficacy and implant success/survival in sites grafted with this material.
Wheat‐dependent exercise‐induced anaphylaxis: subtypes, diagnosis, and management
Authors: Faihs Valentina , Kugler Claudia , Schmalhofer Viktoria , Scherf Katharina Anne , Lexhaller Barbara , Mortz Charlotte G , Bindslev‐Jensen Carsten , Biedermann Tilo , Brockow Knut 
Published: July 2023

SummaryWheat‐dependent exercise‐induced anaphylaxis (WDEIA) is an IgE‐mediated food allergy with allergic symptoms ranging from intermittent urticaria to severe anaphylaxis that occurs when wheat ingestion is combined with augmenting cofactors such as exercise, non‐steroidal anti‐inflammatory drugs, or alcohol. In most cases, patients are identified by sensitization to ω5‐gliadins in the gluten fraction of wheat. ω5‐gliadin‐negative subtypes of WDEIA are often difficult to diagnose and may be caused by Tri a 14 (wheat lipid transfer protein), after percutaneous sensitization with hydrolyzed wheat proteins, or, in rare cases, by cross‐reactivity to grass pollen. Diagnosis is established based on the patients’ history in combination with serum IgE profile, skin testing, basophil activation tests, and challenge tests with cofactors. Individual dietary counselling remains the central pillar in the management of WDEIA patients. A completely wheat‐free diet is a possible option. However, this appears to promote tolerance less than continued regular consumption of gluten‐containing cereals in the absence of cofactors. All patients should have an emergency set for self‐treatment including an adrenaline autoinjector and receive adequate instruction. More data are needed on sublingual immunotherapy for WDEIA, a potentially promising therapeutic prospect. This article provides an overview of current knowledge on the diagnosis and management of WDEIA including an optimized challenge protocol using wheat gluten and cofactors.
Ethics and professionalism among community health workers in Tamil Nadu, India: A qualitative study
Authors: Gopichandran Vijayaprasad , Subramaniam Sudharshini , Palanisamy Balasubramanian , Chidambaram Priyadarshini 
Published: July 2023

AbstractCommunity health workers (CHW) are the backbone of the public health system in developing countries. Little is known about the practice of ethics and professionalism in their work. This study was conducted to explore the experiential wisdom of ethics and professionalism among CHWs in Tamil Nadu. We conducted a qualitative study among 125 CHWs in six districts of Tamil Nadu. We found that the CHWs went beyond the call of their duty to do good to the community. Their conceptualization of autonomy ranged from shared to full paternalistic decision making. The CHWs were sensitive to issues of privacy and confidentiality, but the discussion on these topics were limited. They reflected the societal norms of gender, class, and caste hierarchies in their work. They had to work amidst difficult power struggles and had their own innovative strategies to subvert power. In conclusion, there is a need for framing a code of ethics and professionalism for CHWs and training in ethics and professionalism for them to help them effectively deliberate on ethical issues.
From objects of study to worldmaking beings: The history of botany at the corner of the plant turn
Authors: Gutierrez Kathleen Cruz 
Published: July 2023

AbstractThe “plant turn” of recent years has surfaced as an interdisciplinary position that sees plants as more than inert, passive objects subject to the whims of humans and of more charismatic animal life. Recent research in STEM, the social sciences, and the humanities, alongside scholarly publishing pursuits, have opened a field in which a small yet expanding community of scholars are proposing the worldmaking and agential capacities of plants. While the field of environmental history has already spent decades centering vegetal life and its profound impact on human societies, this essay considers what the plant turn might look like for the history of science and more specifically, the history of botany. What might it mean for plants to transform from objects of study to worldmaking beings in histories of the science? Drawing on two brief historical case studies from the Philippines, the essay invites consideration of plant worldmaking, understood in tandem with alternative ontologies, and of theorizing with plants. Though it may be much too soon to draw conclusions about what the plant turn may portend for the history of science (and the writing that may come from it), historians may have something to offer the plant turn—in discipline and method—in order to make this promising bed of scholarship rigorous and accessible.
Design process knowledge for crisis‐driven information systems solutions: Insights on building digital resilience from an action design research study
Authors: Tim Yenni , Chiew Thiam Kian , Lim Hooi Min , Teo Chin Hai , Ng Chirk Jenn 
Published: July 2023

AbstractAs global disruptions escalate, digital resilience (DR)—the capacity to anticipate, absorb, and adapt to external shocks by leveraging Information Systems (IS)—has become crucial for individuals and organisations confronting and managing unprecedented crises. This research advances understanding on how to develop DR, drawing on insights from an Action Design Research (ADR) study conducted during the COVID‐19 pandemic. Our research explores a particular facet of DR: the capacity to manage exogenous shocks through the design of new IS solutions. We introduce the ADAPT framework, comprising five key enablers—Agility, Designation, Alignment, Participation, and Trust—recommended to support design teams developing IS solutions during and for crises. Our ADR project, which resulted in the creation of a telemonitoring system used by over 115 frontline healthcare workers to monitor the symptoms of more than 1000 COVID‐19 patients, demonstrates the instrumental role these five enablers play in supporting a crisis‐propelled IS design process that is urgent, resource‐limited, and multi‐partite. By presenting new design process knowledge and practical recommendations that guide crisis‐driven IS design, we aim to equip design teams with the understanding they need to effectively navigate similar challenges in the future. We also hope to inspire and support IS researchers to apply their expertise in the design, deployment, and use of IS solutions to contribute to crisis‐driven design endeavours that tackle the pressing and urgent challenges of our time.
Synthesis of new lead‐containing MAX phases of Zr3PbC2 and Hf3PbC2
Authors: Zhang Qiqiang , Wen Bo , Luo Jia , Zhou Yanchun , San Xingyuan , Bao Yiwang , Chu Longsheng , Feng Qingguo , Grasso Salvatore , Hu Chunfeng 
Published: July 2023

AbstractIn this work, two new 312 MAX phases of Zr3PbC2 and Hf3PbC2 were successfully synthesized by spark plasma sintering. It is the first discovery of lead‐containing 312 MAX phases, which together with M2PbC (M = Ti, Zr, Hf) form the lead‐containing MAX phase family. Considering the extremely low electrical conductivity of Hf2PbC, these two new compounds are of great research value. Based on the Rietveld refinement results, their lattice parameters and atomic positions were well determined, as a = 3.3771(5) Å, c = 20.0070(9) Å for Zr3PbC2 and a = 3.3357(1) Å, c = 19.7659(8) Å for Hf3PbC2, where M atoms are located at (0, 0, 0) and (1/3, 2/3, 0.1258(6)[Zr]; 0.1255(2)[Hf]), Pb atoms are located at (0, 0, 1/4), and C atoms are located at (1/3, 2/3, 0.0663(2)[Zr]; 0.0641(3)[Hf]), respectively. Additionally, the typical laminar microstructure of Zr3PbC2 and Hf3PbC2 grains was observed.
Space‐confined growth of CsPbBr3 nanocrystals in mesoporous KIT‐6 and application in LEDs
Authors: Zhu Mengmeng , Liu Yunpeng , Ding Haojie , Zhang Shulan , Qu Mujing , Xuan Tongtong , Li Huili 
Published: July 2023

AbstractAll‐inorganic CsPbX3 (X = Cl, Br, and I) perovskite nanocrystals (NCs) have great application prospects in many fields due to their excellent photoelectric properties. However, CsPbX3 NCs are extremely sensitive to water, heat, light, and oxygen, which leads to dramatic photoluminescence quenching and seriously restricts their future commercial applications. Herein, a novel, simple one‐step solution strategy for synthesizing high‐quality CsPbBr3 NCs was reported. By the combination of the hot‐injection process with the mesoporous template confinement effect of the KIT‐6 matrix, the space‐confined growth of NCs was precisely achieved. The CsPbBr3 NCs encapsulated by KIT‐6 (CsPbBr3@KIT‐6 composite) exhibited a uniform size, a high photoluminescence quantum yield (PLQY) of up to 82%, and a narrow full width at half‐maximum (FWHM) of 24 nm. Most importantly, CsPbBr3@KIT‐6 powder composites had dramatically enhanced light, thermal and water stability in comparison with colloidal CsPbBr3 NCs due to the dual protection of organic ligands and matrix templates. Ultimately, a white light‐emitting diode (LED) device was successfully fabricated by encapsulating a mixture of green‐emitting CsPbBr3@KIT‐6 composite and red‐emitting K2SiF6:Mn4+ phosphor onto a blue‐emitting InGaN LED chip. A color coordinate of (0.327, 0.337) and a wide color gamut of 128% NTSC well demonstrate their potential applications in lighting and display.
Expansions and contractions of the inverted repeat, as well as gene loss and potential pseudogenization shape plastome evolution in Hechtioideae (Bromeliaceae, Poales)
Authors: Ramírez‐Morillo Ivón M. , Espinosa‐Barrera Laura A. , Granados Mendoza Carolina , Vera‐Paz Sandra I. , Díaz Contreras Díaz Daniel D. , Romero‐Soler Katya J. 
Published: July 2023

AbstractFull plastomes have recently proven to be a valuable data source for resolving recalcitrant phylogenetic relationships in the flowering plant family Bromeliaceae. The study of complete plastomes has additionally led to the discovery of new structural rearrangements and advanced our understanding of bromeliad plastome diversity and evolution. Here, we focus on the study of full plastomes of the bromeliad subfamily Hechtioideae to assess phylogenetic relationships, marker informativeness, and plastome structure and evolution. Using whole‐genome sequencing data, we de novo assembled and annotated new plastid genomes of 19 Hechtioideae species plus one representative each from the Pitcairnioideae and Puyoideae subfamilies and compared them with four additional available plastomes from other bromeliad subfamilies. Our phylogenetic analysis using complete plastome sequences not only recovered the three currently recognized genera of Hechtioideae as monophyletic, strongly supporting Mesoamerantha as sister of Bakerantha and Hechtia, but also improved statistical support at different phylogenetic depths within the subfamily. We identified a set of highly informative loci, some of them explored for the first time in Hechtioideae. Structural rearrangements, including expansions and contractions of the inverted repeats, large inversions, and gene loss and potential pseudogenization were detected mainly within the genus Hechtia. Evolutionary trait rate shifts were associated with the size and guanine–cytosine content of the small single copy and inverted repeats.