bluuebunny/crossref_metadata_2025_split huggingface dataset:
UPLOAD MANDIRI PADA REPOSITORI INSTITUSI PERPUSTAKAAN UNIVERSITAS MUHAMMADIYAH SURAKARTA (UMS) LEBIH PRAKTIS DAN PRESTIGE
Authors: Widada Cahyana Kumbul 
Published: August 2023

Penelitian ini membahas tentang repositori institusi Perpustakaan Universitas Muhammadiyah Surakarta (UMS). Tujuan penelitian ini untuk menggambarkan pengelolaan repositori institusi Perpustakaan UMS dengan upload mandiri dan menjelaskan bahwa upload mandiri memberikan manfaat terhadap perkembangan baik personal dan institusi. Penelitian ini menggunakan metode kualitatif deskriptif yaitu dengan melakukan penggambaran pengelolaan Repositori institusi di Perpustakaan UMS dan manfaat dari program upload mandiri dalam pengembangan Repositori institusi, dari sisi pustakawan, dan civitas akademika UMS melalui pengamatan dan wawancara langsung. Berdasarkan data yang diperoleh memberikan gambaran bahwa upload mandiri memberikan kemanfaatan dari visibilitas, mendorong paradigma baru pemanfaatan open access dalam proses publikasi ilmiah dan meningkatkan sarana komunikasi ilmiah di Universitas Muhammadiyah Surakarta. Program upload mandiri institutional repository menjadi lebih praktis dan mudah. Pengelolaan repositori institusi yang optimal akan mengangkat reputasi perguruan tinggi tersebut dan pada akhirnya. Prestige di antara komunitas perguruan tinggi pun akan dapat dirasakan.
The (im)possibility of being a breastfeeding working mother: experiences of Ecuadorian healthcare providers
Authors: Mendoza-Gordillo Maria J. , Bates Benjamin R. , Vivat Bella 
Published: August 2023

BackgroundThroughout the twentieth century, public health agencies and expert healthcare professionals have recognized breastfeeding as the most nutritious and appropriate option for feeding infants. The Ecuadorian government, in line with international guidelines, has therefore developed laws and initiatives to improve the initiation and maintenance of breastfeeding, especially among working mothers. However, breastfeeding rates in Ecuador are low.MethodsA qualitative methodology following social constructionist approaches was applied to explore the breastfeeding experiences of Ecuadorian women who are both mothers and healthcare professionals. Using snowball sampling, 60 healthcare professionals who breastfed their babies: 20 nurses, 20 physicians, and 20 nutritionists, took part in research interviews lasting between 30 and 92 minutes. All participants are currently offering telehealth or face-to-face consultation to their patients in Ecuador. Since Ecuador is a multicultural country, efforts were made to include participants from different regions of the country. Data gathering employed virtual semi-structured interviews including Photovoice. The interviews were carried out in Spanish, following a semi-structured topic guide. The data analysis employed constant comparative methods.ResultsThe analysis produced three overarching themes: Integrating breastfeeding in life and work; Establishing space for breastfeeding at work; Negotiations and tensions. The first theme: Integrating breastfeeding in life and work addresses participants' corporeal and emotional experiences when breastfeeding. This theme also includes the participants' experiences of how they integrated their maternal identity and adapted their breastfeeding bodies to their daily routines. The second theme: Establishing space for breastfeeding at work includes the challenges that some women encounter when incorporating and seeking to combine breastfeeding in their professional identities. The third theme: Negotiations and tensions covers how this group of female healthcare professionals had to negotiate the time and space to continue breastfeeding their children while working.
Association between clustering of cardiovascular risk factors and left ventricular geometric remodeling in Chinese children
Authors: Liu Qin , Wang Huan , Zhao Min , Zhang Cheng , Bovet Pascal , Xi Bo 
Published: August 2023

BackgroundSeveral cardiovascular (CV) risk factors are reported to be associated with abnormal cardiac structure in children and adults. However, no study has assessed the association between clustering of multiple CV risk factors and left ventricular geometric (LVG) remodeling. We examined the association between clustering of CV risk factors and LVG remodeling among Chinese children.MethodsThis cross-sectional study included 1,406 children aged 6–11 years. Clustering of CV risk factors was quantified as the sum of the number of five CV risk factors (abdominal obesity, elevated blood pressure, high fasting blood glucose, high triglycerides and low high-density lipoprotein cholesterol). Based on left ventricular mass index and relative wall thickness (RWT), left ventricular hypertrophy (LVH), high RWT and LVG remodeling [concentric remodeling (CR), eccentric hypertrophy (EH) and concentric hypertrophy (CH)] were defined.ResultsCompared to participants without CV risk factor, those with 1, 2 and ≥3 risk factors were at increased risk of LVH [ORs (95% CIs): 3.49 (2.19–5.56), 5.53 (3.20–9.55), and 19.19 (9.67–38.08), respectively]; corresponding values for high RWT were 2.47 (1.63–3.74), 3.76 (2.25–6.27), and 5.47 (2.65–11.28). Similar associations between clustering of CV risk factors and LVG remodeling were found [CR: 1.71 (1.06–2.76), 2.83 (1.54–5.18), and 3.82 (1.37–10.62); EH: 2.42 (1.42–4.11), 4.23 (2.24–7.96), and 16.86 (7.70–36.92); CH: 14.92 (4.41–50.47), 23.15 (6.32–84.83), and 71.19 (17.09–296.56)].ConclusionCV risk factors in isolation and combination were associated with an increased risk of LVH, high RWT and LVG remodeling among children, emphasizing the need to consider multiple risk factors when assessing the risk of cardiac outcomes.
Manipulation of components of the renin angiotensin system in renal proximal tubules fails to alter atherosclerosis in hypercholesterolemic mice
Authors: Kukida Masayoshi , Amioka Naofumi , Ye Dien , Chen Hui , Moorleghen Jessica J. , Liang Ching-Ling , Howatt Deborah A. , Katsumata Yuriko , Yanagita Motoko , Sawada Hisashi , Daugherty Alan , Lu Hong S. 
Published: August 2023

Background and objectiveWhole body manipulation of the renin-angiotensin system (RAS) consistently exerts profound effects on experimental atherosclerosis development. A deficit in the literature has been a lack of attention to the effects of sex. Also, based on data with gene-deleted mice, the site of RAS activity that influences lesion formation is at an unknown distant location. Since angiotensin (AngII) concentrations are high in kidney and the major components of the RAS are present in renal proximal tubule cells (PTCs), this study evaluated the role of the RAS in PTCs in atherosclerosis development.Methods and resultsMice with an LDL receptor −/− background were fed Western diet to induce hypercholesterolemia and atherosclerosis. We first demonstrated the role of AT1 receptor antagonism on atherosclerosis in both sexes. Losartan, an AngII type 1 (AT1) receptor blocker, had greater blood pressure-lowering effects in females than males, but equivalent effects between sexes in reducing atherosclerotic lesion size. To determine the roles of renal AT1a receptor and angiotensin-converting enzyme (ACE), either component was deleted in PTCs after weaning using a tamoxifen-inducible Cre expressed under the control of an Ndrg1 promoter. Despite profound deletion of AT1a receptor or ACE in PTCs, the absence of either protein did not influence development of atherosclerosis in either sex. Conversely, mice expressing human angiotensinogen and renin in PTCs or expressing human angiotensinogen in liver but human renin in PTCs did not change atherosclerotic lesion size in male mice.ConclusionWhole-body AT1R inhibition reduced atherosclerosis equivalently in both male and female mice; however, PTC-specific manipulation of the RAS components had no effects on hypercholesterolemia-induced atherosclerosis.
Experimental study on flow-induced motion and energy conversion for two triangular prisms in tandem arrangement
Authors: Shao Nan , Xu Guobin , Wu Zhichuan , Liu Fang , Yan Xiang , Wang Xiaoqun 
Published: August 2023

Experimental tests on two tandem triangular prisms were accomplished in synergistic flow-induced motion (FIM) to collect ocean current energy (OCE) with varied spacing ratios and Reynolds number ranges. Typical FIM responses and energy conversion are discussed and presented. The effects of parameters (system stiffness, spacing ratio, and load resistance) were considered to improve the energy harvesting of the system. The main findings can be summarized as follows: 1) with varied spacing ratios between the two tandem prisms, the active power (Pharn) was up to 1.95 times that of the single triangular prism (STP); 2) In general, the harnessed OCE capacity of the upstream triangular prism (UTP) was improved, while the energy harvesting of the downstream triangular prism (DTP) was suppressed by the interaction of the two prisms, 3) In the tests, electricity was generated atU= 0.516 m/s, and the active power, which consistently increased as flow velocity increased, reachedPharn= 32.24 W, with a corresponding efficiency ofηharn= 10.31%; and 4) The best energy conservation performance for harvesting the OCE occurred atL/D= 5, and the optimal load resistance was found atRL= 11 Ω.
Effects of plant diversity and big-sized trees on ecosystem function in a tropical montane evergreen broad-leaved forest
Authors: Li Shuaifeng , Lang Xuedong , Huang Xiaobo , Wang Yanhong , Tang Rong , Liu Wande , Xu Chonghua , Su Jianrong 
Published: August 2023

IntroductionScale dependencies play a vital role in defining the biodiversity-ecosystem functioning relationship in forest ecosystems, which varies based on the magnitude of multiple plant diversity attributes, soil properties, and aboveground biomass in forest ecosystems. However, the effects of plant diversity and big-sized trees on the relationship between plant diversity and aboveground biomass across different scales remain unclear in forest ecosystems.MethodsBased on a 30-ha tropical montane evergreen broad-leaved forest dynamics plot in Yunnan province, China, we comparatively analyzed the importance of scale-dependent effects of multiple plant diversity attributes, soil properties, neighborhood competition intensity and aboveground biomass of big-sized trees, as well as stand structural complexity on aboveground biomass of all woody individuals. The aim is therefore to identify the main predictors for sustaining aboveground biomass of all woody individuals, considering multiple biotic and abiotic factors jointly, as well as underlying mechanisms.ResultsOur results suggest that indicators such as species richness and phylogenetic diversity did not strongly contribute to aboveground biomass of all woody individuals with increasing spatial scales, while aboveground biomass of big-sized trees exhibited the greatest contribution to aboveground biomass of all woody individuals. Stand structural complexity, characterized by variances in woody plant diameter at breast height, also contributed more to aboveground biomass of all woody individuals indirectly via neighborhood competition intensity and aboveground biomass of big-sized trees. Contributions of functional dispersion and community-weighted mean of leaf phosphorus concentration to aboveground biomass of all woody individuals became stronger with increasing spatial scales. Neighborhood competition intensity exhibited a negative linear relationship with aboveground biomass of all woody individuals at the smallest scale, but it affected positively aboveground biomass of all woody individuals across spatial scales, likely due to indirect effects via aboveground biomass of big-sized trees.DiscussionBig-sized trees will likely become more important in biodiversity maintenance and ecosystem function management as deforestation and forest degradation.
Clinical efficacy and drug resistance of ceftazidime-avibactam in the treatment of Carbapenem-resistant gram-negative bacilli infection
Authors: Xiao Shuang , Fu Qianwen , Miao Youhan , Zhao Manna , Lu Shengwei , Xu Jie , Zhao Weifeng 
Published: August 2023

ObjectiveTo examine the clinical efficacy, safety, and resistance of Ceftazidime-Avibactam (CAZ-AVI) in patients with Carbapenem-resistant Gram-negative bacilli (CR-GNB) infections.MethodsWe retrospectively analyzed relevant data of CR-GNB infected patients receiving CAZ-AVI treatment, analyzed relevant factors affecting drug efficacy, and compared the efficacy and safety with patients receiving Polymyxin B treatment.ResultsA total of 139 patients were included. Agranulocytosis, septic shock, SOFA score, and CAZ-AVI treatment course were independent risk factors affecting the prognosis of patients with CR-GNB infection treated with CAZ-AVI while prolonging the treatment course of CAZ-AVI was the only protective factor for bacterial clearance. The fundamental indicators showed no statistically significant differences between CAZ-AVI and Polymyxin B treatment groups. At the same time, the proportion of patients treated with monotherapy was significantly higher in the CAZ-AVI group than in the Polymyxin B group (37.2% vs. 8.9%, p &lt; 0.05), the 30-day mortality rate of the CAZ-AVI treatment group (27.7% vs. 46.7%, p = 0.027) was lower than that of the Polymyxin B treatment group. The 30-day clinical cure rate (59.6% vs. 40% p = 0.030) and 14-day microbiological clearance rate (42.6% vs. 24.4%, p = 0.038) were significantly higher in the CAZ-AVI than in the Polymyxin B treatment group. Eighty nine patients were monitored for CAZ-AVI resistance, and the total resistance rate was 14.6% (13/89). The resistance rates of Carbapenem-resistant Klebsiella pneumoniae (CRKP) and Carbapenem-resistant Pseudomonas aeruginosa (CRPA) to CAZ-AVI were 13.5 and 15.4%, respectively.ConclusionCAZ-AVI has shown high clinical efficacy and bacterial clearance in treating CR-GNB infections. Compared with Polymyxin B, CAZ-AVI significantly improved the outcome of mechanical ventilation in patients with septic shock, agranulocytosis, Intensive Care Unit (ICU) patients, bloodstream infection, and patients with SOFA score &gt; 6, and had a lower incidence of adverse events. We monitored the emergence of CAZ-AVI resistance and should strengthen the monitoring of drug susceptibility in clinical practice and the rational selection of antibiotic regimens to delay the onset of resistance.
Evaluation of MRI in the diagnostic accuracy of extrahepatic metastases in neuroendocrine tumors in comparison with the reference standard somatostatin-receptor–PET/CT
Authors: Ingenerf Maria , Rübenthaler Johannes , Wenter Vera , Zacherl Mathias , Völter Friederike , Winkelmann Michael , Karim Homeira , Schinner Regina , Ricke Jens , Berger Frank , Schmid-Tannwald Christine 
Published: August 2023

PurposeThe aim of this study was to compare the diagnostic performance of different sets of MR sequences in detecting extrahepatic disease of NETs on routine liver magnetic resonance imaging (MRI).MethodOne hundred twenty-seven patients with NETs with and without hepatic and extrahepatic metastases who underwent liver MRI and SSTR-PET/CT were retrospectively analyzed. Two radiologists evaluated in consensus in four sessions: (1) non-contrast T1w+T2w (NC), (2) NC+DWI, (3) NC+ contrast-enhanced T1w (CE), and (4) NC+DWI+CE the presence and number of metastases (lymph nodes, bone, peritoneal surface, lung base, and abdominal organ). Sensitivity, specificity, positive, and negative predictive value for detection of metastases were calculated for each session in a patient-based manner; detection and error rates were calculated for lesion-based analysis. Comparison between the MR-sessions and positron emission tomography–computed tomography (PET/CT) was performed with the McNemar test.ResultsRegarding all 1,094 lesions detected in PET/CT, NC+DWI, and NC, CE+DWI identified most true-positive lesions 779 (71%) and 775 (71%), respectively. Patient-based analysis revealed significantly higher sensitivity by NC+DWI (85%) than NC and NC+CE (p = 0.011 and 0.004, respectively); the highest specificity was reached by NC+CE+DWI (100%). Site-based analysis revealed highest detection rates for lymph node metastases for NC+DWI and NC, CE+DWI (73 and 76%, respectively); error rates were lower for NC, CE+DWI with 5% compared with 17% (NC+DWI). Detection rates for bone metastases were similarly high in NC+DWI and NC, CE+DWI (75 and 74%, respectively), while CE showed no benefit. For peritoneal metastases highest sensitivity was reached by NC+DWI (67%).ConclusionThe combination of NC+DWI showed better sensitivities than the combination of NC+CE. NC+DWI showed similar, sometimes even better sensitivities than NC+CE+DWI, but with lower specificities.
Chest compression rates of 60/min versus 90/min during neonatal cardiopulmonary resuscitation: a randomized controlled animal trial
Authors: Bruckner Marlies , O'Reilly Megan , Lee Tze-Fun , Cheung Po-Yin , Schmölzer Georg M. 
Published: August 2023

BackgroundTo compare chest compression (CC) rates of 60/min with 90/min and their effect on the time to return of spontaneous circulation (ROSC), survival, hemodynamic, and respiratory parameters. We hypothesized that asphyxiated newborn piglets that received CC at 60/min vs. 90/min during cardiopulmonary resuscitation would have a shorter time to ROSC.MethodsNewborn piglets (n = 7/group) were anesthetized, tracheotomized and intubated, instrumented and exposed to 45 min normocapnic hypoxia followed by asphyxia and cardiac arrest. Piglets were randomly allocated to a CC rate of 60/min or 90/min. CC was performed using an automated CC machine using CC superimposed with sustained inflation. Hemodynamic parameters, respiratory parameters, and applied compression force were continuously measured.ResultsThe mean (IQR) time to ROSC was 97 (65–149) s and 136 (88–395) s for CC rates of 60/min and 90/min, respectively (p = 0.31). The number of piglets that achieved ROSC was 5 (71%) and 5 (71%) with 60/min and 90/min CC rates, respectively (p = 1.00). Hemodynamic parameters (i.e., diastolic and mean blood pressure, carotid blood flow, stroke volume, end-diastolic volume, left ventricular contractile function) and respiratory parameters (i.e., minute ventilation, peak inflation and peak expiration flow) were all similar with a CC rate of 60/min compared to 90/min.ConclusionTime to ROSC, hemodynamic, and respiratory parameters were not significantly different between CC rates of 60/min vs. 90/min. Different CC rates during neonatal resuscitation warrant further investigation.
Comparative pharmacokinetics and safety evaluation of high dosage regimens of Andrographis paniculata aqueous extract after single and multiple oral administration in healthy participants
Authors: Songvut Phanit , Rangkadilok Nuchanart , Pholphana Nanthanit , Suriyo Tawit , Panomvana Duangchit , Puranajoti Porranee , Akanimanee Jaratluck , Satayavivad Jutamaad 
Published: August 2023

Background:The prolonged situation of the COVID-19 pandemic, with the emergence of new variants of SARS-CoV-2, not only imposes a financial burden on healthcare supports but also contributes to the issue of medication shortages, particularly in countries with limited access to medical resources or developing countries. To provide an alternative therapeutic approach during this crisis, there is an increasing research that has investigated the potential uses ofAndrographis paniculatain supporting the application of herbal medicine for COVID-19.Purpose:This study aimed to investigate the safety profiles and clinical pharmacokinetics, specifically focusing on dose proportionality of the four major active diterpenoids ofAndrographis paniculataaqueous extract following oral administration of two different high doses of andrographolide.Methods:The participants received the aqueous extract capsules equivalent to 60 or 120 mg of andrographolide; and as multiple doses administered three times daily, calculated as 180 or 360 mg/day of andrographolide. Safety evaluation was assessed following the oral administration of the multiple doses.Results:The results indicated a dose-dependent effect observed between the respective two doses. A twofold increase in the dose of the extract demonstrated twofold higher plasma concentrations of the four major parent compounds; 1) andrographolide, 2) 14-deoxy-11, 12-didehydroandrographolide, 3) neoandrographolide, and 4) 14-deoxyandrographolide, as well as their conjugated metabolites. The observed diterpenoids are biotransformed partly through a phase II metabolic pathway of conjugation, thus reducing in the parent compounds in the plasma and existing the majority as conjugated metabolites. These metabolites are then excreted through the hepatobiliary system and urinary elimination. For the results of the safety evaluation, the occasional adverse events experienced by individuals were of mild intensity, infrequent in occurrence, and reversible to the normal baseline. Safety consideration should be given to the individual patient’s pertinent health conditions when using this extract in patients with hepatic or kidney dysfunction.Clinical Trial Registration:https://www.thaiclinicaltrials.org/show/TCTR20210201005; Identifier: TCTR20210201005.
Diosgenin normalization of disrupted behavioral and central neurochemical activity after single prolonged stress
Authors: Malik Hurmat , Usman Muhammad , Arif Mehreen , Ahmed Zainab , Ali Gowhar , Rauf Khalid , Sewell Robert D. E. 
Published: August 2023

Introduction: Post-traumatic stress disorder (PTSD) is a chronic mental illness triggered by traumatic experiences such as wars, natural disasters, or catastrophes, and it is characterized by anxiety, depression and cognitive impairment. Diosgenin is a steroidal sapogenin with known neuroprotective and antioxidant properties. This study aimed to assess the pharmacological potential of diosgenin in a single prolonged stress (SPS) model of PTSD, plus other behavioral models along with any consequent alterations in brain neurochemistry in male mice.Methodology: SPS was induced by restraining animals for 2 h, followed by 20 min of forced swim, recuperation for 15 min, and finally, exposure to ether to induce anesthesia. The SPS-exposed animals were treated with diosgenin (20, 40, and 60 mg/kg) and compared with the positive controls, fluoxetine or donepezil, then they were observed for any changes in anxiety/depression-like behaviors, and cognitive impairment. After behavioral screening, postmortem serotonin, noradrenaline, dopamine, vitamin C, adenosine and its metabolites inosine and hypoxanthine were quantified in the frontal cortex, hippocampus, and striatum by high-performance liquid chromatography. Additionally, animal serum was screened for changes in corticosterone levels.Results: The results showed that diosgenin reversed anxiety- and depression-like behaviors, and ameliorated cognitive impairment in a dose-dependent manner. Additionally, diosgenin restored monoamine and vitamin C levels dose-dependently and modulated adenosine and its metabolites in the brain regions. Diosgenin also reinstated otherwise increased serum corticosterone levels in SPS mice.Conclusion: The findings suggest that diosgenin may be a potential candidate for improving symptoms of PTSD.