bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of risk prediction models for depression combining genetic and early life risk factors
Authors: Lu Tianyuan , Silveira Patrícia Pelufo , Greenwood Celia M. T. 
Published: July 2023

BackgroundBoth genetic and early life risk factors play important roles in the pathogenesis and progression of adult depression. However, the interplay between these risk factors and their added value to risk prediction models have not been fully elucidated.MethodsLeveraging a meta-analysis of major depressive disorder genome-wide association studies (N = 45,591 cases and 97,674 controls), we developed and optimized a polygenic risk score for depression using LDpred in a model selection dataset from the UK Biobank (N = 130,092 European ancestry individuals). In a UK Biobank test dataset (N = 278,730 European ancestry individuals), we tested whether the polygenic risk score and early life risk factors were associated with each other and compared their associations with depression phenotypes. Finally, we conducted joint predictive modeling to combine this polygenic risk score with early life risk factors by stepwise regression, and assessed the model performance in identifying individuals at high risk of depression.ResultsIn the UK Biobank test dataset, the polygenic risk score for depression was moderately associated with multiple early life risk factors. For instance, a one standard deviation increase in the polygenic risk score was associated with 1.16-fold increased odds of frequent domestic violence (95% CI: 1.14–1.19) and 1.09-fold increased odds of not having access to medical care as a child (95% CI: 1.05–1.14). However, the polygenic risk score was more strongly associated with depression phenotypes than most early life risk factors. A joint predictive model integrating the polygenic risk score, early life risk factors, age and sex achieved an AUROC of 0.6766 for predicting strictly defined major depressive disorder, while a model without the polygenic risk score and a model without any early life risk factors had an AUROC of 0.6593 and 0.6318, respectively.ConclusionWe have developed a polygenic risk score to partly capture the genetic liability to depression. Although genetic and early life risk factors can be correlated, joint predictive models improved risk stratification despite limited improvement in magnitude, and may be explored as tools to better identify individuals at high risk of depression.
Development of a questionnaire on nutritional knowledge for the obese hospitalized patient: the NUTRIKOB questionnaire
Authors: Mambrini Sara Paola , Soranna Davide , Averna Eva , Di Guglielmo Giulia , Lucchetti Elisa , Tinozzi Tiziana , Vinci Calogero , Barbieri Valerio , Zambon Antonella , Bertoli Simona , Scacchi Massimo 
Published: July 2023

IntroductionDifferent approaches, involving different areas and figures, are useful for the rehabilitation of obese subjects through a multidisciplinary hospital path. A focal point of rehabilitation is represented by education on healthy eating by increasing the dietary knowledge patients. Few tools investigating food knowledge are available in Italy: therefore, the need has emerged to develop easy-to-use tools for clinical practice that allow to detect food knowledge to set up a more targeted food re-education. The following work aimed at building and validating a questionnaire capable of investigating the dietary knowledge of the population affected by obesity.MethodsA pool of experts carried out a review of the literature, gathering all the information necessary to select and construct the best set of questions and the format of the final project of the questionnaire. During statistical analysis the validity, reproducibility and stability of the questionnaire were investigate in a sample of 450 subjects with obesity.ResultsEarly analysis disclosed that 5 questions of the original questionnaire had no discriminating power. The successive validation phases were successful, confirming good content validity, stability and reproducibility over time.DiscussionThe questionnaire has all the characteristics to be considered a valid tool for investigating dietary knowledge in the obese population. The psychometric tests confirmed a good internal consistency of the structure, a validity of the content, a good reproducibility and stability over time.
Associations of Migration, Socioeconomic Position and Social Relations With Depressive Symptoms – Analyses of the German National Cohort Baseline Data
Authors: Vonneilich Nico , Becher Heiko , Bohn Barbara , Brandes Berit , Castell Stefanie , Deckert Andreas , Dragano Nico , Franzke Claus-Werner , Führer Amand , Gastell Sylvia , Greiser Halina , Keil Thomas , Klett-Tammen Carolina , Koch-Gallenkamp Lena , Krist Lilian , Leitzmann Michael , Meinke-Franze Claudia , Mikolajczyk Rafael , Moreno Velasquez Ilais , Obi Nadia , Peters Annette , Pischon Tobias , Reuter Marvin , Schikowski Tamara , Schmidt Börge , Schulze Matthias , Sergeev Dmitry , Stang Andreas , Völzke Henry , Wiessner Christian , Zeeb Hajo , Lüdecke Daniel , von dem Knesebeck Olaf 
Published: July 2023

Objectives: We analyze whether the prevalence of depressive symptoms differs among various migrant and non-migrant populations in Germany and to what extent these differences can be attributed to socioeconomic position (SEP) and social relations.Methods: The German National Cohort health study (NAKO) is a prospective multicenter cohort study (N = 204,878). Migration background (assessed based on citizenship and country of birth of both participant and parents) was used as independent variable, age, sex, Social Network Index, the availability of emotional support, SEP (relative income position and educational status) and employment status were introduced as covariates and depressive symptoms (PHQ-9) as dependent variable in logistic regression models.Results: Increased odds ratios of depressive symptoms were found in all migrant subgroups compared to non-migrants and varied regarding regions of origins. Elevated odds ratios decreased when SEP and social relations were included. Attenuations varied across migrant subgroups.Conclusion: The gap in depressive symptoms can partly be attributed to SEP and social relations, with variations between migrant subgroups. The integration paradox is likely to contribute to the explanation of the results. Future studies need to consider heterogeneity among migrant subgroups whenever possible.
HUBUNGAN SELF EFFICACY DENGAN KEPATUHAN MINUM OBAT PADA PASIEN TUBERCULOSIS PARU DI PUSKESMAS PEKAYON JAYA KECAMATAN BEKASI SELATAN KOTA BEKASI
Authors: Saputri Tania Anggraini , Istiqomah Istiqomah 
Published: July 2023

Tuberkulosis merupakan salah satu penyakit menular yang dapat disembuhkan hanya saja dalam pengobatannya membutuhkan waktu yang cukup lama dan meminum obat secara terus-menerus. Tingginya kasus Tuberkulosis Paru(TB Paru) dan rendahnya angka capaian pengobatan yang salah satunya diakibatkan putus obat menyebabkan pengobatan memakan waktu yang lebih lama. Kepatuhan merupakan ketaatan pada tujuan yang telah ditentukan. Salah satu faktor yang mempengaruhi kepatuhan ialah self efficacy. Self efficacy adalah persepsi diri atau keyakinan diri mengenai kemampuan melakukan tindakan yang dihaarapkan. Tujuan penelitian ini untuk mengetahui hubungan self efficacy dengan kepatuhan minum obat pada pasien TB paru di Puskesmas Pekayon Jaya. Metode penelitian menggunakan deskriptif korelasional dengan pendekatan cross sectional, tempat penelitian di Puskesmas Pekayon Jaya. Jumlah populasi 50 pasien TB Paru dengan sampel yang diambil menggunakan teknik total sampling. Analisa yang digunakan univariat dan bivariat menggunakan uji chi-square dengan α = 5% (0,05).Hasil penelitian analisis univariat didapatkan gambaran self efficacy rendah 54% dan Kepatuhan Minum Obat rendah 42% analisa bivariate diperoleh nilai p atau Asym. Sig. (2-sided) = 0,002 dengan nilai α = 5% (0,05). Simpulan terdapat hubungan antara self efficacy dengan kepatuhan minum obat pada pasien TB paru di Puskesmas Pekayon Jaya. Saran Agar lebih meningkatkan self efficacy dengan kepatuhan minum obat.
GAMBARAN TINDAKAN ORANG TUA DALAM MENGATASI EFEK SAMPING KEMOTERAPI PADA ANAK KANKER
Authors: Nabilla Hanaa , Utami Agnita , Roza Adila Dian 
Published: July 2023

Orang tua merupakan pemberi perawatan dan dukungan pada anak kanker untuk memenuhi seluruh kebutuhan pasien termasuk mengatasi efek samping kemoterapi yang dirasakan pasien. Penelitian bertujuan untuk mengetahui tindakan yang dilakukan orang tua dalam mengatasi efek samping kemoterapi pada anak dengan metode penelitian deskriptif kuantitatif dengan responden 30 orang tua anak kanker. Instrumen penelitian menggunakan kuesioner. Hasil penelitian didapatkan tindakan yang dilakukan orang tua untuk mengatasi mual muntah mayoritas adalah pemberian obat (61.1%). Tindakan mengatasi kerontokan rambut dengan menggunakan minyak kelapa/ kemiri ke kepala pasien (38.8%). Untuk mengatasi sariawan, mulut kering dan sakit tenggorokan banyak diberikan kumur-kumur mulut 3-4 kali sehari (57.1%). Untuk masalah diare orang tua memberikan minum air putih 8-10 gelas perhari (66.6%). Untuk masalah gangguan saraf otot diberikan obat mengatasi nyeri (33,3%). Tindakan mengatasi kelelahan dianjurkan istirahat atau tidur ketika merasa lelah (44.4%). Tindakan mengatasi risiko infeksi (demam, batuk, flu) banyak diberikan minum air putih dan konsumsi makanan sehat (78.5%). Tindakan mengatasi anemia orang tua memberikan makanan yang mengandung zat besi pada anak (77.7%). Masalah kulit banyak diatasi dengan mengoleskan handbody lotion (60.0%). Masalah konstipasi diatasi orang tua dengan memberi anak minum air putih (63.6%). Tindakan mengatasi efek samping penurunan nafsu makan paling banyak dilakukan orang tua menemani anak dalam setiap makannya dan memberikan minuman sehat (70.5%). Diharapkan petugas YKAKI dapat membimbing orang tua terhadap tindakan yang dapat diberikan orang tua terkait efek samping kemoterapi anak agar tidak menimbulkan komplikasi kedepannya.
Programa de entrenamiento de parotidectomia en modelo cadavérico perfundido
Authors: Jara Contreras Rocio , Rappoport W. Daniel , Moraga T. Felipe , Soto V Miguel , Aguilar N William 
Published: July 2023

Introducción: La parotidectomía es una cirugía infrecuente y técnicamente compleja determinada por la dificultad de disección del nervio facial, cuya lesión produce alto grado de morbilidad en los pacientes. Los modelos de simulación animales no logran reproducir las características de la anatomía regional, por lo que se hace necesario explorar otras alternativas para el entrenamiento de estas habilidades. Nuestro objetivo es evaluar un programa de entrenamiento de técnicas de parotidectomía en un modelo cadavérico perfundido. Métodos: Se diseñó un programa educacional de Kern de entrenamiento de residentes de Cirugía de Cabeza y Cuello para la realización de parotidectomía total en un modelo cadavérico perfundido. La evaluación se realizó mediante el modelo de Kirkpatrick, en los niveles 1 (reacción), 2A (cambio de actitudes) y 2B (adquisición de conocimientos y habilidades). Resultados: Se elaboró un programa teórico-práctico basado en cátedras y simulación de alta fidelidad. En su mayoría los participantes: recomendarían el curso (Nivel 1); tuvieron mayor motivación para el aprendizaje (Nivel 2) y presentaron mejores indicadores sobre conocimientos, habilidades y percepción de mejoría de sus competencias (Nivel 2B). Conclusion: La utilización de un programa de parotidectomia simulado en un modelo de alta fidelidad basado en modelos cadavéricos humanos perfundidos es una alternativa que mejora la calidad de entrenamiento y es útil y factible para el aprendizaje de técnicas de parotidectomía en residentes de Cirugía de Cabeza y Cuello.
EDUKASI DAN DEMONSTRASI PEMBUATAN SABUN PENCUCI TANGAN ANTISEPTIK BERBAHAN KERTAS PADA KELOMPOK WANITA TANI DI KOTA PALEMBANG
Authors: Marlina Dewi , Fadly Fadly 
Published: July 2023

Mencuci tangan dengan sabun dikenal juga sebagai salah satu upaya pencegahan penyakit. Hal ini dilakukan karena tangan sering kali menjadi agen yang membawa kuman dan menyebabkan patogen berpindah dari satu orang ke orang lain. Salah satu bagian tubuh yang rentan terkena bakteri dan virus adalah tangan. Bentuk sabun yang belum banyak beredar dipasaran adalah sabun dalam bentuk lembaran atau dalam bentuk kertas. Bentuk lembaran akan memberikan keuntungan, yaitu mudah disimpan dan dapat dibawa kemana-mana, serta pemakaian satu lembar satu kali pakai dapat menjaga kwalitas sabun. Maka telah dilakukan kegiatan Pengabdian kepada Masyarakat berupa edukasi tentang perilaku hidup bersih dan sehat, serta demo pembuatan sabun cuci tangan Antiseptik dari kertas pada Kelompok Wanita Tani BPP Talang Betutu Palembang.. Target capaian adalah adanya peningkatan pengetahuan dan keterampilan, yang diukur dengan menggunakan kuesioner melalui pretest dan postest, dan evaluasi terhadap hasil demostrasi. Target capaian adalah adanya peningkatan pengetahuan dan keterampilan, yang diukur dengan menggunakan kuesioner melalui pretest dan postest, dan evaluasi terhadap hasil demostrasi. Dari kegiatan ini didapatkan peningkatan pengetahuan masyarakat yang bermakna dan peningkatan keterampilan tentang pembuatan Sabun Pencuci Tangan Antiseptik Berbahan Kertas. Peserta puas terhadap pelaksanaan Edukasi dan Demostrasi dan menyatakan bahwa Edukasi dan Demostrasi ini memberikan manfaat.
Analisis Kandungan Logam Berat (Pb, Hg, Cu dan As) Pada Kerupuk Kemplang Di Desa Tebing Gerinting Utara, Kecamatan Indralaya Selatan, Kabupaten Ogan Ilir
Authors: Ariansya Kiki Agus , Yuliati Kiki , R.J. Siti Hanggita 
Published: July 2023

The purpose of research was to investigated the heavy metal (Pb, Hg, Cu, and As) content on the kerupuk kemplang (traditional fish cracker) at the North Tebing Gerinting Region, District of South Indralaya, Ogan Ilir Regency.This research was conducted on September until May 2012 the north region Tebing Gerinting, district of South Indralaya, Ogan Ilir regency and Laboratory of Balai Riset dan Standarisasi Industri dan Perdagangan, Palembang.This research used survey method to obtain primary data. The data showed the value of heavy metal content differs, there were fish source (marine fish and fresh water fish),Â location (in the roadside and in the village), and drying method (with and without rack) and each sample was replicated two times.Â The parameter of observation were conducted on plumbum (Pb), mercury (Hg), copper (Cu) and arsenic (As).The result of the research revealedÂ that plumbum (Pb) of Kerupuk kemplang with raw material from marine fishÂ and dried in the roadside with rack had value of plumbum 0,0025 mg/kg and in the roadside without rack had 0,0108 mg/kg. Drying on the village with rackÂ had 0,005 mg/kg and without rack had 0,0005 mg/kg. Kerupuk kemplang with raw material from freshwater fish and dried in the rack of roadside had value of Â plumbum 0,0021 mg/kg and without rack had the value of 0,0055 mg/kg. Drying on the village with rack had 0 mg/kg and without rack had 0,005 mg/kg.Â Plumbumâ€™s content on kerupuk kemplang still below the threshold were allowed, had the value of 0,3 mg/kg, but it should be able attention because of its heavy metal that could be accumulated in humanâ€™s body especially on kidney, heart and brain.
PENGUJIAN AKTIVITAS ANTIOKSIDAN EKSTRAK BUNGA LOTUS (Nelumbo nucifera)
Authors: Romadanu Romadanu , Hanggita Siti , Lestari Shanti Dwita 
Published: July 2023

The purpose of this research was to observe antioxidant activity of lotus leaves extract (Nelumbo nucifera). The extractionÂ process was carried out using three different solvents namely methanol, ethyl acetate and n-hexane. The observed parameters were extraction yields phytochemical compounds (alkaloid, flavonoid and tanin) and antioxidant activity using DPPH method. The results showed that the methanol extract exhibited the highest yield with a value of 0.708% and had a flavonoid tannin content of 1161 ppm. The antoxidant activity of the same extract as indicated by IC50 value was 199 ppm. The extract ethyl acetate and n-hexane solvents did not show potential antioxidant activities
A Narrative Inquiry of Two English Teachers’ Identity Construction
Authors: Fitaloka Devia , Gandana Isti Siti Saleha 
Published: July 2023

Teacher identity is one of the essential aspects influencing the form and quality of educational processes. The present study examines the narratives of one of the writers, Devia, and an English teacher, Trisa, throughout their learning and teaching experiences and the process that were involved as they negotiated their identities as teachers. The data were collected from an autobiographical narrative of Devia as an English teacher, as well as intensive life-history interviews with Trisa. Analysis of the narratives and interview data led to four major themes: inspiring figures, teaching practicum experiences, becoming an English teacher, and pursuing a postgraduate study. The findings revealed that Devia’s and Trisa’s engagement in the practices and activities of learning and teaching shaped their teacher identity constructions. Keywords: narrative inquiry, teacher identity, teacher identity construction
Impactos psicosociales de la pandemia covid- 19 en la educación
Authors: Benítez Carolina E., 
Published: July 2023

La Pandemia COVID-19 y su rápida propagación ha requerido como medida sanitaria el confinamiento para evitar el contagio. Este aislamiento social generó riesgos en la salud mental y efectos psicológicos a corto y largo plazo. Además, el cambio de la relación presencial profesor alumnos otra virtual ha traído consigo consecuencias como a falta de acceso a la explicación detallada. El presente estudio tiene como objetivo analizar los impactos psicosociales de la pandemia de COVID-19 en la educación. Se realizó una revisión exhaustiva de la literatura científica publicada en los últimos cinco años. En cuanto a la metodología, se utilizó un enfoque de investigación documental, revisando y analizando los artículos seleccionados en busca de información relevante sobre los efectos psicosociales de la pandemia en el ámbito educativo. Se aplicaron criterios de inclusión y exclusión para seleccionar los estudios más pertinentes y se llevó a cabo un análisis comparativo de los resultados. Este estudio resalta la importancia de abordar los impactos psicosociales de la pandemia en la educación y propone la implementación de estrategias de apoyo emocional y social para mitigar los efectos negativos. Se destaca la necesidad de fortalecer la comunicación entre docentes y alumnos, así como de brindar recursos y herramientas adecuadas para el aprendizaje virtual.
A Blueprint for the Milky Way’s Stellar Populations. IV. A String of Pearls—the Galactic Starburst Sequence
Authors: An Deokkeun , Beers Timothy C. , Lee Young Sun , Masseron Thomas 
Published: July 2023

Abstract
We continue our series of papers on phase-space distributions of stars in the Milky Way based on photometrically derived metallicities and Gaia astrometry, with a focus on the halo−disk interface in the local volume. To exploit various photometric databases, we develop a method of empirically calibrating synthetic stellar spectra based on a comparison with observations of stellar sequences and individual stars in the Sloan Digital Sky Survey, the SkyMapper Sky Survey, and the Pan-STARRS1 surveys, overcoming band-specific corrections employed in our previous work. In addition, photometric zero-point corrections are derived to provide an internally consistent photometric system with a spatially uniform metallicity zero-point. Using our phase-space diagrams, we find a remarkably narrow sequence in the rotational velocity (v

ϕ
) versus metallicity ([Fe/H]) space for a sample of high proper-motion stars (>25 mas yr−1), which runs along Gaia Sausage/Enceladus (GSE) and the Splash substructures and is linked to the disk, spanning nearly 2 dex in [Fe/H]. Notably, a rapid increase of v

ϕ
from a nearly zero net rotation to ∼180 km s−1 in a narrow metallicity interval (−0.6 ≲ [Fe/H] ≲ −0.4) suggests that some of these stars emerged quickly on a short gas-depletion timescale. Through measurements of a scale height and length, we argue that these stars are distinct from those heated dynamically by mergers. This chain of high proper-motion stars provides additional support for recent discoveries suggesting that a starburst took place when the young Milky Way encountered the gas-rich GSE progenitor, which eventually led to the settling of metal-enriched gas onto the disk.
Les libéraux du Trienio constitucional (1820-1823) en quête de leurs origines : des fictions oniriques au service d’une mythologie politique
Authors: Le Guellec Maud 
Published: July 2023

Le Trienio constitucional, pendant lequel le roi absolutiste Ferdinand VII est contraint de régner avec un gouvernement libéral, constitue un moment crucial de l’histoire de l’Espagne. C’est en effet en 1820 que, pour la première fois, l’idéologie issue du Cadix de 1812 a enfin l’occasion d’être véritablement mise en pratique. Mais une fois aux commandes, les libéraux doivent s’imposer comme un acteur majeur sur l’échiquier politique national, et modifier les mentalités face à des schémas absolutistes bien ancrés dans les esprits. Dans cette tâche épineuse de mise en place d’un nouvel imaginaire politique, ils font appel à tous les canaux possibles : textes, images, cérémonies, symboles, etc. Ils mobilisent, également, différentes stratégies de légitimation qui alternent ou se combinent selon les moments, les publics et les supports. Cet article se propose d’explorer une des stratégies auxquelles ont recours les libéraux du Trienio – la mise en scène de la genèse du libéralisme –, à travers l’un des corpus propices à cette mise en mots et en images d’un mythe des origines : les fictions oniriques. La réflexion prendra notamment appui sur El Anteojo mágico, o La visión de los dos palacios en el bosque (D.J.A.R., Oviedo, 1820) ; El Dos de mayo. Fragmento (in El Espectador, 2 mai 1821) ; Mi sueño, o visión de un hombre libre (B… M…, Séville, 1821) ; Mi viaje a la luna o sueños políticos y morales. Primera insurrección del pueblo de Airebi (in Diario constitucional de Palma, 11 et 12 mai 1820) et Profecía de lo que se verá el día 9 de julio de 1820 (Madrid, 1820).
The Safety to Switch from Constant Voltage to Constant Current with a Mixed Internal Pulse Generator in Deep Brain Stimulation
Authors: Öztürk Gülşah , Paksoy Kemal 
Published: July 2023

Abstract

Background:
Deep brain stimulation (DBS) is an efficient modality for the treatment of movement disorders. Differing from the constant voltage (CV)-DBS devices, constant current (CC)-DBS devices may allow more precise stimulation of the target brain regions since they are less influenced by impedance. If internal pulse generators (IPGs) of DBS devices are required to be connected with electrodes of different brands, employing proper adapters is necessary. Such connected DBS devices are called mixed or hybrid devices.

Objectives:
As there is sparse information about the clinical mixed devices, we studied their safety and efficacy.

Materials and Methods:
Clinical scores of 13 patients implanted with mixed DBS devices were determined with the Unified Parkinson’s Disease Rating Scale (UPDRS) in Parkinson’s disease (PD) (n = 10) and with the Burke–Fahn–Marsden Dystonia Rating Scale (BFMDRS) in dystonia (n = 3). Patient satisfaction was assessed with the Timmerman questionnaire. The Clinical Global Impression Improvement (CGI-I) Scale was also evaluated.

Results:
Patients’ overall satisfaction was considerably higher with mixed devices. The UPDRS and BFMDRS clinical scores did not significantly differ after switching to a mixed DBS device. Three patients before the DBS switch suffered from side effects under the CV mode. These patients got rid of the side effects in their follow-up with a reduction in pulse width values.

Discussion:
Mixed devices working in CC mode are well tolerated with high patient satisfaction.

Conclusion:
Besides patient satisfaction, mixed IPGs are also considered safe.