bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploration of Novel PDEδ Inhibitor Based on Pharmacophore and
Molecular Docking against KRAS Mutant in Colorectal Cancer
Authors: Mouhcine Mohammed , Kadil Youness , Rahmoune Imane , Filali Houda 
Published: April 2023

Aim:
The prenyl-binding protein, phosphodiesterase-δ (PDEδ), is essential for the localization
of prenylated KRas to the plasma membrane for its signaling in cancer.

Introduction:
The general objective of this work was to develop virtually new potential inhibitors of
the PDEδ protein that prevent Ras enrichment at the plasma membrane.

Methods:
All computational molecular modeling studies were performed by Molecular Operating Environment
(MOE). In this study, sixteen crystal structures of PDEδ in complex with fifteen different
fragment inhibitors were used in the protein-ligand interaction fingerprints (PLIF) study to identify the
chemical features responsible for the inhibition of the PDEδ protein. Based on these chemical characteristics,
a pharmacophore with representative characteristics was obtained for screening the BindingDB
database. Compounds that matched the pharmacophore model were filtered by the Lipinski filter.
The ADMET properties of the compounds that passed the Lipinski filter were predicted by the
Swiss ADME webserver and by the ProTox-II-Prediction of Toxicity of Chemicals web server. The
selected compounds were subjected to a molecular docking study.

Results:
In the PLIF study, it was shown that the fifteen inhibitors formed interactions with residues
Met20, Trp32, Ile53, Cys56, Lys57, Arg61, Gln78, Val80, Glu88, Ile109, Ala11, Met117, Met118,
Ile129, Thr131, and Tyr149 of the prenyl-binding pocket of PDEδ. Based on these chemical features,
a pharmacophore with representative characteristics was composed of three bond acceptors, two hydrophobic
elements, and one hydrogen bond donor. When the pharmacophore model was used in the
virtual screening of the Binding DB database, 2532 compounds were selected. Then, the 2532 compounds
were screened by the Lipinski rule filter. Among the 2532 compounds, two compounds met
the Lipinski's rule. Subsequently, a comparison of the ADMET properties and the drug properties of
the two compounds was performed. Finally, compound 2 was selected for molecular docking analysis
and as a potential inhibitor against PDEδ.

Conclusion:
The hit found by the combination of structure-based pharmacophore generation, pharmacophore-
based virtual screening, and molecular docking showed interaction with key amino acids in
the hydrophobic pocket of PDEδ, leading to the discovery of a novel scaffold as a potential inhibitor
of PDEδ.
Oral Linezolid Induced Early Onset Hepatic Encephalopathy- A Case
Report of 65-year Old Diabetic Female
Authors: Upadhyay Mitul , Purohit Bhargav , Pargi Piyush 
Published: April 2023

Introduction:
Linezolid is increasingly utilized to treat gram-positive bacteria that are
resistant to other antibiotics like vancomycin-resistant Staphylococcus aureus, methicillinresistant
Staphylococcus aureus as well as drug-resistant tuberculosis. It acts by inhibiting protein
synthesis in bacteria. Although it is a relatively safe medicine, many reports of hepatotoxicity
and neurotoxicity linked to long-term usage have been received but patients with pre-existing
risk factors, such as diabetes and alcoholism, may have toxicity even after short-term use of linezolid.

Case Presentation:
Here we are presenting a case of a 65-year-old female with diabetes who developed
hepatic encephalopathy after one week of treatment with linezolid prescribed for nonhealing
diabetic ulcer after a culture sensitivity test. After the use of linezolid 600 mg BD for 8
days patient developed altered sensorium and breathlessness and had high bilirubin, SGOT, and
SGPT. She was diagnosed with hepatic encephalopathy. Linezolid was withdrawn and after 10
days all laboratory parameters for liver function test were improved.

Conclusion:
Care should be taken when prescribing linezolid in such patients with pre-existing
risk factors as they are prone to develop hepatotoxic and neurotoxic adverse effects even after
short-term use of linezolid.
Effect of Organic Solvents on Acetylcholinesterase Inhibition and Enzyme Kinetics
Authors: Baswar Dnyaneshwar , Mishra Awanish 
Published: April 2023

Background:
The most widespread signalling system in the brain is the cholinergic system,
which plays a central role in the progress of Alzheimer’s diseases (AD). Current AD treatment primarily
targets the neuronal acetylcholinesterase (AChE) enzyme. The finding of AChE activity may play a
vital role in optimizing assays for drug discovery of new AChE inhibiting agents. During in-vitro assay
of AChE activity, the use of various organic solvents is imperative.

Objective:
The present study is designed to evaluate the effect of different organic solvents on enzyme
activity and enzyme kinetics.

Method:
Organic solvents' AChE inhibitory potential (including enzyme kinetics: Vmax, Km and
Kcat) was evaluated using substrate velocity curve by using non-linear reversion Michaelis-Menten
kinetic function.

Results:
DMSO was found to have the most potent AChE inhibitory effect, followed by acetonitrile
and ethanol. The kinetic study revealed DMSO as a mixed inhibitory effect (competitive/noncompetitive
manner), ethanol as non-competitive, and acetonitrile as a competitive inhibitor of the
AChE enzyme. Methanol has shown a negligible impact on enzyme inhibition and kinetics, suggesting
its suitability for the AChE assay.

Conclusion:
We assume that our study results will help design the experimental protocols and support
analyzing investigational outcomes while screening and biological evaluation of new molecules using
methanol as solvent/cosolvent.
RNA-based Therapeutics: Master Regulator for Bioengineering Systems in Medicine World
Authors: Singla Richu , Arora Malika , Bansal Parveen 
Published: April 2023

Abstract:
Ribonucleic acid (RNA) and its types have emerged as master regulators of biological processes and expanded knowledge regarding the role of RNA in the gene expression inside the cell have dramatically changed the therapeutic strategies in the past few years. RNA has become a focus for developing novel therapeutic schemes and hence RNA-based therapies, particularly in viral dis-eases have become more enthralling and promising. It is due to the fact that RNA offers various ad-vantages in disease management as it can be edited and customized in its various forms such as sec-ondary and tertiary structures. Principles and mechanisms regarding RNA therapeutics are well de-scribed in volumes, however, the information regarding long-awaited RNA-based drug develop-ment and potential hurdles as well as barriers in the way is still scattered. In this regard, these agents are required to overcome a plethora of barriers such as stability of drug targets, immunogenicity, adequate binding, targeted delivery, etc. to become effective drugs. Most of the trials are changing their way from in-vitro to in-vivo studies and it is not far away when RNA-based therapeutics will find their way from bench to bedside. In this communication, the authors give a brief review of im-portant recent advances in above said domains of miRNA therapeutics.
The Efficacy of Current Medications and Biomarkers in Hepatic Ischemia-
Reperfusion Damage
Authors: Kumar  Gupta Jeetendra , Singh Kuldeep , Singh Krishanveer , Kumar Shivendra 
Published: April 2023

Abstract:
Hepatic ischemia-reperfusion injury is a complicated systemic process that affects several tissues and organs in addition to being a pathologic process that affects the liver. Several studies have shown that hepatic reperfusion severely impairs liver function. That also produces irreversible damage that causes dysfunction of many organs. The regulation of hepatic ischemia-reperfusion injury (IRI) is influenced by various factors, such as mitochondrial damage, anaerobic metabolism, intracellular Ca2+ overload, oxidative stress and ROS production, and chemokines as well as cytokines generation. Most of the cytokines are generated by helper T cells and neutrophils. A target of Matrix Metalloproteinases (MMPs) in chronic and acute liver injury caused by ischemia can be a significant facilitator of early leukocyte recruitment. Neutrophil gelatinase-associated lipocalin (NGAL) and MMPs could be employed as indicators of the severity of ischemia-reperfusion (I-R) injuries. This review examines the relationship between the components of hepatic IRI, MMPs, and the available pharmaceutical treatments for this condition.
Strategi pengembangan karakter kepemimpinan mahasiswa melalui pembelajaran Pendidikan Agama Islam di Politeknik
Authors: Suhendar Waway Qodratulloh , Milanti Ajeng Ayu , Suhartini Ida , Rahman Rini 
Published: April 2023

Artikel ini membahas strategi pengembangan karakter kepemimpinan pada mahasiswa melalui pembelajaran PAI. Dari hasil kajian yang dilakukan oleh tim peneliti dari berbagai literatur, saat ini sedang terjadinya krisis kepemimpinan di dalam semua level, baik pada tingkat lokal, nasional, maupun global. Krisis kepemimpinan terjadi akibat ketidakmampuan memanajemen krisis multidimensional dan perilaku amoral. Tim peneliti menilai bahwa keberadaan mata kuliah PAI mempunyai peran penting dalam penanaman dan pembinaan karakter kepemimpinan kepada mahasiswa. Hal tersebut karena mata kuliah PAI mempunyai posisi penting dalam kurikulum pendidikan di Indonesia, mengacu pada peraturan UU No. 20 Tahun 2003 dan berbagai turunannya yang menempatkan mata kuliah PAI sebagai mata kuliah wajib nasional. Penelitian ini menggunakan metode kualitatif-deskritif. Data dikumpulkan melalui studi lapangan, wawancara dan studi dokumen pada perkuliahan PAI di Polban dan PNJ. Hasil kajian menunjukkan bahwa perkuliahan PAI mempunyai peran dalam mengembangkan karakter kepemimpinan mahasiswa melalui 2 langkah strategi, yakni mengkaji konsep kepemimpinan dalam Al-Quran kemudian menginsersikan karakter kepemimpinan dalam bahan ajar PAI dan melaksanakan pembelajaran dengan pendekatan pembelajaran aktif (active learning).This article discussed strategies for developing students’ leadership character through Islamic education. From the results of the study conducted by the researchers, taken from various literatures, there is currently a leadership crisis occurring at all levels, both at the local, national, and global levels. The leadership crisis occurs due to the inability to manage multidimensional crises and immoral behavior. The researchers considered that the existence of the PAI course played an important role in instilling and fostering leadership characters in the students. This is because PAI subjects have a vital position in the education curriculum in Indonesia, referring to Law no. 20 of 2003 and its various derivatives, which place the PAI course as a national compulsory subject. This study used a qualitative-descriptive method. Data was collected through field studies, interviews and document studies at PAI lectures in Polban and PNJ. The results of the study show that PAI lectures have a role in developing student leadership character through 2 strategic steps, namely examining the concept of leadership in the Qur’an and then introducing leadership character into PAI teaching materials and carrying out learning with an active learning approach (active learning).
Analisis Penerapan Perhitungan Fisik dan Pencatatan Persediaan pada Koperasi Karyawan
Authors: Arlindayani Erika Vegy , Yutanto Hariadi , Sihotang Ellen Theresia 
Published: April 2023

Abstrak: Analisis Penerapan Perhitungan Fisik dan Pencatatan Persediaan pada Koperasi Karyawan. Koperasi karyawan STIE Perbanas Surabaya memiliki permasalahan perbedaan pencatatan dengan jumlah fisik persediaan. Penelitian ini bertujuan untuk mengetahui penyebab perbedaan tersebut dan solusinya. Metode penelitian yang digunakan adalah deskriptif kualitatif. Data diperoleh melalui observasi dan wawancara kemudian diolah dan dibandingkan antara teori dengan proses pelaksanaan perhitungan fisik persediaan. Hasil dari penelitian ini mengungkapkan bahwa terdapat perbedaan jumlah fisik dan pencatatan pada akun persediaan karena kesalahan pencatatan pada sistem kasir pada awal periode sehingga berdampak pada periode selanjutnya. Selisih juga terjadi pada proses inputan transaksi penjualan harian dan kartu gudang tidak digunakan. Solusi terhadap permasalahan tersebut adalah melakukan penyesuaian dan penerapan perhitungan fisik persediaan secara rutin sebagai bagian dari implementasi pengendalian internal.Kata kunci: Persediaan, Perhitungan Fisik, Pengendalian InternalAbstract: Analysis of the Application of Physical Calculations and Inventory Recording of Employee Cooperative. The Employee Cooperatives of STIE Perbanas, Surabaya, has difference problems between the recorded amount and the physical amount of inventory. The study aims to determine the causes of these differences and the solutions. The study method used is descriptive qualitative. The data were obtained through observation and interviews, and then processed and compared with the theory and implementation process of inventory physical count. The results of this study revealed that there were differences between physical amount and recorded amount of inventory due to recording errors in the cashier system at the beginning of the period, so that they affected the next period. The differences also occurred in the daily sales transaction input process and warehouse cards not used. The solution to these problems is making adjustments and applying inventory stock opname regularly as a part of internal control implementation.Keywords: Inventory, Stock Opname, Internal Control
Pengejawantahan Teori Psikoanalitik pada Etika Bisnis
Authors: Nur Amalia Shabrina Rahutami , Hamidah Hamidah 
Published: April 2023

ABSTACTHow can the unconscious side of managerial style cause the failure of business ethics? So far, discussions about unethical behavior in companies, especially fraud, are often linked to motivational theories that only pay attention to the human side of consciousness. The psychoanalytic theory is one of the well-known theories in explaining the human unconscious not to act unethically. This article aims to review how the manifestation of psychoanalytic theory explains unethical behavior in a business organization which is illustrated through the failure to achieve stakeholder theory. This research contributes to the management accounting by providing a new perspective on ethical violations and fraud from the perspective of human psychology. The results of this research show that the subconscious side of the manager can be manifested in his managerial style and exploiting the loopholes in the stakeholder theory causes ethical failure.Keywords: Psychoanalytic Theory, Business Ethic, Stakeholder TheoryABSTRAKBagaimanakah sisi alam bawah sadar manajerial style dapat menyebabkan kegagalan etika bisnis? Selama ini pembahasan mengenai perilaku tidak etis dalam perusahaan, khususnya fraud, seringkali dihubungkan pada teori-teori motivasi yang hanya memperhatikan sisi consciousness dari manusia. Teori psikoanalitik merupakan salah satu teori yang terkenal dalam menjelaskan sisi unconsciousness manusia untuk tidak berbuat tidak etis. Artikel ini bertujuan untuk mengulas bagaimana manifestasi dari teori psikoanalitik dalam menjelaskan perilaku tidak etis dalam sebuah organisasi bisnis yang digambarkan melalui kegagalan pencapaian teori stakeholder. Penelitian ini berkontribusi pada akuntansi manajemen dengan memberikan perspektif baru atas tindakan melanggar etika dan fraud dari sisi ilmu psikologis manusia. Hasil penelitian menunjukkan bahwa sisi bawah sadar manajer dapat termanifestasi dalam gaya manjerialnya dan dengan memanfaatkan celah pada teori stakeholder menyebabkan kegagalan etika.Kata Kunci: Teori Psikoanalitik, Etika Bisnis, Teori Stakeholder
Panel Data Model in Analyzing Factors Affecting Market Value Added (MVA) in Companies Listed on the LQ45 Index
Authors: Ardana Yudhistira , Syamsiyah Nur , Faiz Akhmad 
Published: April 2023

ABSTRACTTo increase shareholder value, companies are required to improve their financial performance. MVA (Market Value Added) is one of the company's performance indicators for increasing MVA. This study aims to measure the factors that affect the market value added (MVA) of companies listed on the LQ45 index using a panel data model. The variables used are economic value added (X1), return on equity (X2), return on assets (X3), earnings per share (X4), dividend per share (X5), and market value added (Y). The best model used in this study is the random-effects model. The estimation results show that all variables used in this study (EVA, ROA, ROE, EPS, and DPS) have a significant effect on the MVA of companies incorporated in the LQ45 index, with a percentage of 64.68%. The results of the partial estimation of the ROA, ROE, and EVA variables have a significant positive effect on MVA. The DPS variable has no significant positive impact on MVA, and the EPS variable has no significant negative impact on MVA.Keywords: Economic Value Added, Profitability Ratio, Market Value AddedABSTRAKUntuk meningkatkan nilai pemegang saham, perusahaan dituntut dalam meningkatkan kinerja keuangannya. Market Value Added (MVA) merupakan salah satu indikator kinerja perusahaan dalam meningkatkan nilai tambah pasar. Penelitian ini bertujuan untuk mengukur faktor-faktor yang mempengaruhi Market Value Added (MVA) perusahaan yang terdaftar pada indeks LQ45 dengan menggunakan model data panel. Variabel yang digunakan adalah Economic Value Added (X1), Return on Equity (X2), Return on Asset (X3), Earning Per Share (X4), Dividend Per Share (X5), dan Market Value Added (Y). Model terbaik yang digunakan dalam penelitian ini adalah model random-effect. Hasil estimasi menunjukkan bahwa semua variabel yang digunakan dalam penelitian ini (EVA, ROA, ROE, EPS, dan DPS) berpengaruh signifikan terhadap MVA perusahaan yang tergabung dalam indeks LQ45 dengan persentase 64,68%. Hasil estimasi parsial variabel ROA, ROE, dan EVA berpengaruh positif signifikan terhadap MVA. Variabel DPS berpengaruh positif tidak signifikan terhadap MVA dan variabel EPS berpengaruh negatif tidak signifikan terhadap MVA.Kata Kunci: Nilai Tambah Ekonomi, Rasio Profitabilitas, Nilai Tambah Pasar
Correlation Among Dividend Policy and Market Value of Equity In Banking Industry: A Residual Income Approach
Authors: Fadila Ardhiani , Nugraheni Siwi , Utami Kery 
Published: April 2023

ABSTRACTThis research aims to examine the correlation between dividend payment and the market value of equity of banking firms in the Indonesia Stock Exchange-listed company. The sample includes firms focused on the banking sector period between 2011 to 2020. This study employs the residual income approach based on Ohlson's (1995) valuation model. The models are tested using panel regression analysis. Moreover, additional tests are used to ensure the main results. The finding shows that dividend payment has an insignificant effect on the market value of equity. The analysis states that the use of Ohlson's (1995) model and the firm's book value are statistically significant factors in determining the market value of equity. The study suggests that the dividend irrelevance hypothesis is valid in the case of banking firms on IDX. This paper encourages empirical evidence about the relationship between dividend payment and market value on Indonesia Stock Exchange, more importantly, in the banking firms.Keywords: Dividend Policy, Market Value, Residual IncomeABSTRAKTujuan penelitian ini untuk mengetahui korelasi antara pembayaran dividen dan nilai pasar saham pada perusahaan perbankan di Bursa Efek Indonesia. Sampel penelitian ini berfokus pada perusahaan perbankan selama periode 2011 sampai 2020. Penelitian ini menggunakan pendekatan residual income oleh model valuasi Ohlson’s (1995). Model penelitian menggunakan analsis regresi panel. Selanjutnya, pengujian tambahan dilakukan untuk memastikan hasil pengujian utama. Temuan penelitian menunjukan bahwa pembayaran dividen tidak memiliki pengaruh terhadap nilai pasar saham. Hasil analisis menyatakan model Ohlson’s (1995) dan nilai buku perusahaan secara statistik berpengaruh terhadap faktor penentu nilai pasar saham. Penelitian ini membuktikan teori ketidakrelevanan dividen berlaku dalam kasus perusahaan perbankan di BEI. Studi ini mendorong bukti empiris mengenai hubungan antara pembayaran dividen dan nilai pasar di BEI, khususnya pada perusahaan bank.Kata Kunci: Kebijakan Dividen, Laba Sisa, Nilai Pasar
The Effect of Coronavirus Disease (Covid19) Positive Cases on Indonesia’s Gold Price
Authors: Hasan Abdullah Abdurahman , Dewanti Patriani Wahyu , Abdullah Shamsul Nahar 
Published: April 2023

ABSTRACTIn 2020, the world was shaken by the presence of the COVID-19 pandemic, which resulted in various sectors, such as financial markets, rupiah exchange rates and commodities. This study aims to determine the effects of Daily Positive Cases of COVID-19 on Indonesia's Gold Prices. The period used in this research is eight months, starting from 13th March 2020 to 13th November 2020. This type of research is based on associative research using a quantitative approach. The sample in this study was obtained from the official website of the Task Force for Handling COVID-19 and Precious Metals, amounting to 238. The data analysis technique used was regression analysis. The research showed that the daily positive cases of COVID-19 have a positive impact on Gold Prices in Indonesia. This is supported by the regression coefficient value of 16.944 and a significance value of 0.00 0.05. The coefficient of determination is 0.549. It shows the magnitude of the influence of the variable is 54.9%, while the rest is explained by other variables outside of this study.Keywords: Covid-19, Gold Price, Associative ResearchABSTRAKPada tahun 2020, dunia diguncangkan dengan keberadaan pandemi COVID-19 yang mengakibatkan berbagai macam sektor seperti pasar keuangan, nilai tukar rupiah dan komoditas. Penelitian ini mempunyai tujuan untuk mengetahui pengaruh Kasus Positif Harian COVID-19 terhadap Harga Emas di Indonesia. Periode yang digunakan dalam penelitian ini adalah delapan bulan, yaitu mulai dari tanggal 13 Maret 2020 sampai dengan tanggal 13 November 2020. Jenis penelitian ini merupakan penelitian asosiatif dengan menggunakan pendekatan kuantitatif. Sampel dalam penelitian ini diperoleh dari situs resmi Satuan Tugas Penanganan COVID-19 dan Logam Mulia yang berjumlah 238. Teknik analisis data yang digunakan adalah statistik deskriptif, uji asumsi klasik dan analisis regresi sederhana. Berdasarkan hasil penelitian, penelitian ini menunjukkan bahwa Kasus Positif Harian COVID-19 berdampak positif terhadap Harga Emas di Indonesia. Hal ini dibuktikan dengan nilai koefisien regresi sebesar 16,944 dan nilai signifikansi sebesar 0,00 0,05. Nilai koefisien determinasi yaitu sebesar 0,549. Hal ini menunjukkan besarnya pengaruh variabel adalah sebesar 54,9% sedangkan sisanya dijelaskan oleh variabel lain di luar penelitian ini.Kata Kunci: Covid-19, Harga Emas, Penenlitian Asosiatif