bluuebunny/crossref_metadata_2025_split huggingface dataset:
Biliary Complications After Liver Transplantation in the United States: Changing Trends and Economic Implications
Authors: Manay Priyadarshini , Seth Abhinav , Jackson Kyle , Lentine Krista L. , Schnitzler Mark A. , Xiao Huiling , Segev Dorry L. , Axelrod David A. 
Published: March 2023

Background.
Biliary complications (BCs) continue to impact patient and graft survival after liver transplant (LT), despite improvements in organ preservation, surgical technique, and posttransplant care. Real-world evidence provides a national estimate of the incidence of BC after LT, implications for patient and graft outcomes, and attributable cost not available in transplant registry data.

Methods.
An administrative health claims–based BC identification algorithm was validated using electronic health records (N = 128) and then applied to nationally linked Medicare and transplant registry claims.

Results.
The real-world evidence algorithm identified 97% of BCs in the electronic health record review. Nationally, the incidence of BCs within 1 y of LT appears to have improved from 22.2% in 2002 to 20.8% in 2018. Factors associated with BCs include donor type (living versus deceased), recipient age, diagnosis, prior transplant, donor age, and donor cause of death. BCs increased the risk-adjusted hazard ratio (aHR) for posttransplant death (aHR, 1.43; P < 0.0001) and graft loss (aHR, 1.48; P < 0.0001). Nationally, BCs requiring intervention increased risk-adjusted first-year Medicare spending by $39 710 (P < 0.0001).

Conclusions.
BCs remain an important cause of morbidity and expense after LT and would benefit from a systematic quality-improvement program.
Sleep/Wake Disorders After Sports Concussion: Risks, Revelations, and Interventions
Authors: Grigg-Damberger Madeleine M. 
Published: March 2023

Summary:Sleep-wake disturbances (SWDs) are among the most prevalent, persistent, and often disregarded sequelae of traumatic brain injury. Identification and treatment of SWDs in patients with traumatic brain injury is important and can complement other efforts to promote maximum functional recovery. SWDs can accentuate other consequences of traumatic brain injury, negatively affect mood, exacerbate pain, heighten irritability, and diminish cognitive abilities and the potential for recovery. The risk for sports injuries increases when athletes are sleep deprived. Sleep deprivation increases risk-taking behaviors, predisposing to injuries. SWDs are an independent risk factor for prolonged recovery after sports-related concussion. SWDs following sports-related concussion have been shown to impede recovery, rehabilitation, and return to preinjury activities.
Mean structure of the supercritical turbulent spiral in Taylor–Couette flow
Authors: Wang B. , Mellibovsky F. , Ayats R. , Deguchi K. , Meseguer A. 
Published: March 2023

The large-scale laminar/turbulent spiral patterns that appear in the linearly unstable regime of counter-rotating Taylor–Couette flow are investigated from a statistical perspective by means of direct numerical simulation. Unlike the vast majority of previous numerical studies, we analyse the flow in periodic parallelogram-annular domains, following a coordinate change that aligns one of the parallelogram sides with the spiral pattern. The domain size, shape and spatial resolution have been varied and the results compared with those in a sufficiently large computational orthogonal domain with natural axial and azimuthal periodicity. We find that a minimal parallelogram of the right tilt significantly reduces the computational cost without notably compromising the statistical properties of the supercritical turbulent spiral. Its mean structure, obtained from extremely long time integrations in a co-rotating reference frame using the method of slices, bears remarkable similarity with the turbulent stripes observed in plane Couette flow, the centrifugal instability playing only a secondary role.This article is part of the theme issue ‘Taylor–Couette and related flows on the centennial of Taylor’s seminalPhilosophical transactionspaper (Part 2)’.
Modelling the viral dynamics of the SARS-CoV-2 Delta and Omicron variants in different cell types
Authors: McCormack Clare P. , Yan Ada W. C. , Brown Jonathan C. , Sukhova Ksenia , Peacock Thomas P. , Barclay Wendy S. , Dorigatti Ilaria 
Published: March 2023

AbstractWe use viral kinetic models fitted to viral load data fromin vitrostudies to explain why the SARS-CoV-2 Omicron variant replicates faster than the Delta variant in nasal cells, but slower than Delta in lung cells, which could explain Omicron’s higher transmission potential and lower severity. We find that in both nasal and lung cells, viral infectivity is higher for Omicron but the virus production rate is higher for Delta. However, the differences are unequal between cell types, and ultimately leads to the basic reproduction number and growth rate being higher for Omicron in nasal cells, and higher for Delta in lung cells. In nasal cells, Omicron alone can enter via a TMPRSS2-independent pathway, but it is primarily increased efficiency of TMPRSS2-dependent entry which accounts for Omicron’s increased activity. This work paves the way for using within-host mathematical models to understand the transmission potential and severity of future variants.
Division of labor promotes the entrenchment of multicellularity
Authors: Conlin Peter L. , Goldsby Heather J. , Libby Eric , Skocelas Katherine G. , Ratcliff William C. , Ofria Charles , Kerr Benjamin 
Published: March 2023

AbstractSimple multicellularity evolves readily in diverse unicellular species, but nascent multicellular groups are prone to reversion to unicellularity. Successful transitions to multicellularity therefore require subsequent mutations that promote the entrenchment of the higher-level unit, stabilizing it through time. Here we explore the causes of entrenchment using digital evolution. When faced with a trade-off between cellular metabolic productivity and information fidelity, digital “multicells” often evolve reproductive division of labor. Because digital “unicells” cannot circumvent this trade-off, unicellular revertants tend to exhibit low fitness relative to their differentiated multicellular ancestors. Thus, division of labor can drive the entrenchment of multicellularity. More generally, division of labor may play a crucial role in major transitions, enriching the complexity and functionality of higher-level units while enhancing their evolutionary stability.
Cross-species single-cell comparison of systemic and cardiac inflammatory responses after cardiac injury
Authors: Cortada Eric , Yao Jun , Xia Yu , Dündar Friederike , Zumbo Paul , Yang Boris , Rubio-Navarro Alfonso , Perder Björn , Qiu Miaoyan , Pettinato Anthony M. , Homan Edwin A. , Stoll Lisa , Betel Doron , Cao Jingli , Lo James C. 
Published: March 2023

AbstractThe immune system coordinates the response to cardiac injury and is known to control regenerative and fibrotic scar outcomes in the heart and subsequent chronic low-grade inflammation associated with heart failure. Here we profiled the inflammatory response to heart injury using single cell transcriptomics to compare and contrast two experimental models with disparate outcomes. We used adult mice, which like humans lack the ability to fully recover and zebrafish which spontaneously regenerate after heart injury. The extracardiac reaction to cardiomyocyte necrosis was also interrogated to assess the specific peripheral tissue and immune cell reaction to chronic stress. Cardiac macrophages are known to play a critical role in determining tissue homeostasis by healing versus scarring. We identified distinct transcriptional clusters of monocytes/macrophages in each species and found analogous pairs in zebrafish and mice. However, the reaction to myocardial injury was largely disparate between mice and zebrafish. The dichotomous response to heart damage between the mammalian and zebrafish monocytes/macrophages may underlie the impaired regenerative process in mice, representing a future therapeutic target.
Germline-mediated immunoediting sculpts breast cancer subtypes and metastatic proclivity
Authors: Houlahan Kathleen E. , Khan Aziz , Greenwald Noah F , West Robert B. , Angelo Michael , Curtis Christina 
Published: March 2023

AbstractCancer represents a broad spectrum of molecularly and morphologically diverse diseases. Individuals with the same clinical diagnosis can have tumors with drastically different molecular profiles and clinical response to treatment. It remains unclear when these differences arise during disease course and why some tumors are addicted to one oncogenic pathway over another. Somatic genomic aberrations occur within the context of an individual’s germline genome, which can vary across millions of polymorphic sites. An open question is whether germline differences influence somatic tumor evolution. Interrogating 3,855 breast cancer lesions, spanning pre-invasive to metastatic disease, we demonstrate that germline variants in highly expressed and amplified genes influence somatic evolution by modulating immunoediting at early stages of tumor development. Specifically, we show that the burden of germline-derived epitopes in recurrently amplified genes selects against somatic gene amplification in breast cancer. For example, individuals with a high burden of germline-derived epitopes inERBB2,encoding human epidermal growth factor receptor 2 (HER2), are significantly less likely to develop HER2-positive breast cancer compared to other subtypes. The same holds true for recurrent amplicons that define four subgroups of ER-positive breast cancers at high risk of distant relapse. High epitope burden in these recurrently amplified regions is associated with decreased likelihood of developing high risk ER-positive cancer. Tumors that overcome such immune-mediated negative selection are more aggressive and demonstrate an “immune cold” phenotype. These data show the germline genome plays a previously unappreciated role in dictating somatic evolution. Exploiting germline-mediated immunoediting may inform the development of biomarkers that refine risk stratification within breast cancer subtypes.
The role of digital orientation in moderating the relationship between innovation and internationalization
Authors: You Hui Wei , Brahmana Rayenda Khresna 
Published: March 2023

PurposeThis research aims to examine the moderating role of digital orientation (DO) on the relationship between innovation and internationalization by framing the relationship under an agency, resource-based view (RBV) and organization orientation (OO) theory.Design/methodology/approachThis study focuses on a sample of 392 listed companies in Malaysia from 2011 to 2018 and estimates the model under the double clustered regression, dynamic GMM panel model and one-lagged model to tackle endogeneity and reversal causality. This study also did a logit model as an additional robustness check.FindingsThe findings support the RBV perspective: Companies with intensive innovation have high internationalization. However, the findings refute OO theory by revealing the evidence that DO leads to low internationalization. Supplemental analysis suggests that innovation impact on internationalization occurs in assets and sales internationalization (exports).Research limitations/implicationsAccording to the RBV theory, innovation is strategic value creation for the organization to achieve competitiveness. A company can expand its market internationally when the business process is more productive and efficient due to innovation. The innovation process is closely related to DO. Hence, this research explores whether DO may strengthen the effect of innovation on the internationalization process.Originality/valueThis study examines the effect of DO on innovation and internationalization implementation by contesting agency theory, RBV theory and OO theory within an emerging country context.
Do institutional determinants matter for FDI inflows location choice? Evidence from sub-national panel data in India
Authors: Goswami Vandana 
Published: March 2023

PurposeThe present paper makes an attempt to investigate the determinants that affect FDI inflows distribution among Indian states. Together with traditional determinants, the impact of institutional determinants on state-level FDI inflows distribution in India has been analysed.Design/methodology/approachThe study uses panel data for a period of 20 years (2000–2019) for 17 groups of Indian states (29 states and 7 UTs). The empirical evidence is based on the panel data method and the findings support Dunning's OLI theory. As the data for some indicators for the institutional environment is not available at the state level, hence we used component analysis to arrive at the single component for the institutional factor. The study takes into account corruption, legal system, industrial disputes, man-days lost, labour availability, political risk, protection of IPR and agglomeration as potential macroeconomic and institutional determinants.FindingsResults show that FDI inflows into Indian states is driven mainly by institutional environment. From our analysis, the author infers that the institutional variables such as legal system, IPR, corruption, political instability play an important role in determining the distribution of FDI inflows at the state level in India. Together with that GFCF and agglomeration are also important determinants of state-wise FDI inflows.Research limitations/implicationsThe major limitation of the study is that it doesn't include moderated impact of economic and institutional determinants of FDI inflows in Indian states, which can be an avenue for future research. Future research can also carried out taking district-level data to further examine the determinants at district level in India.Originality/valueThe contribution of the present paper is three-fold, first, the author constructs a measure of different institutional variables, after normalization of data for the period 2000–2019, and the author choose the highest explaining factor with the highest variance explained then we constructed the indices for select variable, which further has been used in the panel data analysis technique. The author has found that macroeconomic variables, as well as institutional variables, are significant to attract FDI at the state level in India. The paper shows that corruption, political risk, IPR and legal system are the major institutional determinants of FDI inflows in India at the state level. States with higher domestic investment attract more FDI inflows, moreover, agglomeration is a very important determinant as the investors are more confident in investing at the same location, the reason behind this may be that the investors want to avoid the registration procedure for new land, administrative formalities or they feel more secure at the same place and keen to invest at the same place again.
The social role of supply chain firms during the pandemic period
Authors: Najaf Khakan , Dhiaf Mohamed Mahjoub M. , Marashdeh Hazem , Atayah Osama F. 
Published: March 2023

PurposeSocial risk management is vital for growth and business continuity. This study investigates the social risk shift in supply chain management during the Coronavirus Disease 2019 (COVID-19) pandemic.Design/methodology/approachData were retrieved from Bloomberg between 2010 and 2021 regarding all supply chain enterprises from nine countries. The authors undertake a confirmatory examination of formulated hypotheses. Social supply chain risk (SSCR) refers to “firms that took the necessary steps to decrease social risks in their supply chain. Social risks involve the child or forced labor, poor working conditions, lack of a living and fair or minimum wage”. The authors complement the analysis and address the endogeneity issue using the dynamic generalized moments method (GMM).FindingsA significant positive relationship between COVID-19 and SSCR was discovered in this study. Due to the COVID-19 pandemic, supply chain firms faced supply chain social risk. Notably, SSCR policies differ from one country to another during this period.Research limitations/implicationsThe research has some limitations. The sample data are limited to 9 countries. Furthermore, it was somewhat difficult to determine the country-wise difference using COVID-19 as a dummy variable. Future research may adopt qualitative approaches, such as structural or semi-structural interviews.Practical implicationsThe results have important implications for supply chain practitioners to consider the critical role of social risk in their operations. COVID-19 has exposed the new political economy and re-centered governments as the key actors in tackling grand challenges to safeguard workers, produce socially useful products and protect their stakeholders. Also, the study highlights the importance of governments and policymakers having a well-structured regulatory framework and environment for firms to comply with the social norms in their supply chain management. Finally, the study's findings should encourage supply chain managers to adopt a proactive mechanism that reduces the social risk impacts of pandemics.Originality/valueConsidering the historical backdrop of the COVID-19 pandemic, this study is unique in measuring the SSCR of enterprises from a worldwide viewpoint.
The impact of spirituality on religious competition in the USA marketplace of religion
Authors: von der Ruhr Marc 
Published: March 2023

PurposeThe USA has long been known to provide a competitive environment in which religions compete for believers. The data clearly show winners and losers in this marketplace. Major Christian denominations are generally experiencing a decline in membership while religious “nones” are growing in number. Of note, the recent Pew studies of the US Religious Landscape (2008 and 2015a) indicate that measures of spirituality are rising in this environment. This paper empirically investigates how the demand for spirituality in religion may better understand these trends.Design/methodology/approachThis paper applies ordinary least squares to survey data from the 2015 Pew study to empirically investigate how belonging to a major Christian faith and attending religious services impacts feeling of spirituality, while conditioning on a host of other demographic variables, in order to better understand these trends.FindingsThe author finds that being a member of a Christian denomination generally reduces the measure of spirituality relative to religious “nones.” However, this effect is almost always offset by a measure of attendance at religious services suggesting spirituality is positively associated with social interaction.Originality/valueThe results have implications for religious leaders concerned about maintaining and growing the church's membership. The results suggest that Church leaders may benefit from de-emphasizing hierarchical top-down rules and emphasizing community.Peer reviewThe peer review history for this article is available at: https://publons.com/publon/10.1108/IJSE-05-2022-0342
Does online–offline channel integration matter for supply chain resilience? The moderating role of environmental uncertainty
Authors: Wu Xia , Li Yang , Zhu Zujun 
Published: March 2023

PurposeDrawing on dynamic capability theory, this study investigates how online–offline channel integration (OOCI) affects a firm's supply chain resilience and how such an effect is moderated by market turbulence and regulatory uncertainty.Design/methodology/approachA sample of 273 Chinese firms that conduct online and offline business and hierarchical regression analysis were used to examine the research model.FindingsThe results suggest that the effect of OOCI on supply chain resilience differs in terms of its dimensions (i.e. information integration, transaction integration and service integration). While information integration and service integration were positively associated with supply chain resilience, transaction integration had a non-significant relationship with supply chain resilience. Moreover, market turbulence negatively moderated the effect of transaction integration and positively moderated the effect of service integration. Regulatory uncertainty positively moderated the effect of transaction integration and negatively moderated the effect of service integration. Implications and suggestions for future research are discussed.Originality/valueThis study examines the effect of OOCI on supply chain resilience. It further explores the influence of market turbulence and regulatory uncertainty on the relationship between OOCI and supply chain resilience.
Modelling the barriers of rice supply chain in India using the fuzzy logic approach
Authors: Sreejith J. , Saleeshya P.G. 
Published: March 2023

PurposeRice is an important grain in Indian scenarios, and the purpose of the research work is to identify the attributes which can be the possible barriers in the traditional rice supply chain network.Design/methodology/approachA multilevel conceptual model is developed based on the literature review, and a field study is conducted by administering a questionnaire from the experts. Fuzzy logic methodology and a ranking score method is applied to identify the rice supply chain performance and the barriers of the traditional rice supply chain network.FindingsThe rice supply chain performance index for the traditional rice supply chain network is obtained, and the performance of the existing rice supply chain is found to be “fair”. The “information flow” is the attribute that can be a critical weak attribute in the traditional rice supply chain network. A proposed model of the blockchain technology-enabled rice supply chain network is developed as a solution for the “information flow” barrier.Research limitations/implicationsThe present research work is focussed on the generalized rice supply chain model of the Indian scenario, and more detailed studies can be carried out based on the regional issues.Originality/valueThe rice supply chain plays an important role in Indian economic development, and hence the current research paper focusses on identifying the barriers and the performance of the existing rice supply chain network.