bluuebunny/crossref_metadata_2025_split huggingface dataset:
Uric acid mitigates cognitive deficits via transcription factor EB - mediated microglial autophagy in mice models of Alzheimer's disease
Authors: Xiao Qian , Wang Jiaojiao , Tian Qiuyun , Tian Na , Tian Qi , He Xin , Wang Yutian , Dong Zhifang 
Published: September 2023

Abstract
Clinical trials have demonstrated the potential neuroprotective effects of uric acid in Alzheimer's disease. However, the specific mechanism underlying the neuroprotective effect of uric acid remains unclear. In the present study, we investigated the neuroprotective effect and underlying mechanism of uric acid in Alzheimer's disease mouse models. Various behavioral tests including elevated plus maze, Barnes maze, and Morris water maze was conducted to evaluate the impact of uric acid on cognitive function in β-amyloid microinjection and APP23/PS45 double transgenic mice models of Alzheimer's disease. Immunohistochemical staining was employed to visualize pathological changes in the brains of Alzheimer's disease mice. Western blotting and immunofluorescence techniques were used to assess levels of autophagy-related proteins and transcription factor EB -related signaling pathways. BV2 cells were used to investigate the association between uric acid and microglial autophagy. We reported that uric acid treatment significantly alleviated memory decline and β-amyloid pathology in β-amyloid -induced Alzheimer's disease model mice and APP23/PS45 double transgenic Alzheimer's disease model mice. Furthermore, uric acid activated microglia and upregulated the autophagy-related proteins such as LC3II/I ratio, Beclin-1 and LAMP1 in the hippocampus of Alzheimer's disease model mice. Similarly, uric acid protected BV2 cells from β-amyloid toxicity by upregulating the expressions of Beclin-1, LAMP1 and the LC3II/I ratio, whereas genetic inhibition of transcription factor EB completely abolished these protective effects. Our results indicate that uric acid may serve as a novel activator of transcription factor EB to induce microglia autophagy and facilitate β-amyloid degradation, thereby improving cognitive function in Alzheimer's disease model mice. Therefore, these findings suggest that uric acid may be a novel therapeutic agent for Alzheimer's disease treatment.
Impact of Chilling Temperature and Its Exposure Period on Survival, Flight Ability and Sterility of Aedes aegypti (Linnaeus) (Diptera: Culicidae)
Authors: Hossain Md. Forhad , Ghosh Ananna , Hossain M Aftab , Seheli Kajla 
Published: September 2023

Abstract

The tiny bloodsuckers Aedes aegypti is the primary vector of some fatal diseases like dengue, zika and yellow fever which presents a significant concern for the healthcare sector of Bangladesh. To manage this insect pest, the feasibility of sterile insect technique (SIT) in Bangladesh is being investigated for which quality radio-sterilized males are indispensable. Typically, the sterile males are chilled at low temperature to facilitate their transportation from rear-out-facility to the release site, concurrently to minimize the metabolism, stress and physical damage. In this study, the impact of chilling temperatures (4, 7 and 10°C) and exposure periods (1, 4, 8 and 24h) have been studied on the survival, chill-coma recovery rate (CCRR), induced sterility and flight ability of lab-reared local A. aegypti strain. Different chilling temperatures showed insignificant effect on CCRR except the 24h exposure duration. Log-rank test of Kaplan-Meier survival curve resulted the significant effect of chilling temperature and duration on the survival. Notably, the chilling temperature of 7°C exposed for 1h was found to be optimum in terms of survival. Hence, the induced sterility and flight ability were studied only for this specific temperature and duration, revealing the insignificant effects between the sterile-chilled and sterile but non-chilled A. aegypti. This study underscores the recommendation to chill the mosquitoes at 7°C for 1h which will be helpful for the implementation of SIT in Bangladesh.
The study of the role of Purified anti-mouse CD193 (CCR3) Antibody in allergic rhinitis mouse animal models
Authors: Bao Youwei , Wu Zhaokun , Zhu Xinhua , Jiang Yinli , Zhang Ying , Zhu Yu , Deng Yi , Liu Wenqiang , Wei Mengyi , Xiao Yating , Luo Weiming , Liu Zheng , Wu Jun 
Published: September 2023

Abstract
The pathogenesis of allergic asthma is similar to that of allergic rhinitis, with inflammation cells producing and releasing inflammatory mediators and cytokines closely related to CCR3. Related literature has reported that the use of CCR3 monoclonal antibodies can improve symptoms such as allergic enteritis and allergic pneumonitis. Based on the theory of "one airway, one disease", the use of CCR3 monoclonal antibodies may also have a similar effect on allergic rhinitis. However, there are currently few research reports on the application of CCR3 monoclonal antibodies in allergic rhinitis. Therefore, this study aims to explore the effective concentration of CCR3 monoclonal antibodies and compare the effects of different dosing methods, as well as detecting the lung condition of allergic mice to investigate whether antibody treatment can protect the lungs.
On the basis of successfully constructing a mouse model of allergic rhinitis, this study uses intraperitoneal injection of three different doses of CCR3 mAb (5uL/mg, 10uL/mg, and 20uL/mg) to observe its therapeutic effects: observing changes in tissue morphology of nasal mucosa, infiltration of inflammation, and using ELISA to detect changes in relevant inflammatory mediators and cytokines, studying the role of CCR3 mAb in inhibiting CCR3-related actions on the nasal mucosa of allergic rhinitis mice. Furthermore, based on the effective concentration, two dosing methods were compared: intraperitoneal injection and topical administration to study the therapeutic effects of both dosing methods.
Potential of Waste Wood Ash as an Additive in Soil Grouting
Authors: Hamed Majid , Abdulhaleem Khamees N. , Mohammed Waleed 
Published: September 2023

Abstract
The study investigated the use of waste wood ash (WWA) as a cement replacement in low-plasticity clayey soil. Various replacement ratios of WWA were examined (0%, 5%, 10%, 15% and 20%). A binder (cement + WWA) to soil was 0.2 and the water to the binder ratios was 1.4, 1.6 and 1.8 has been conducted. The results indicated a moderate improvement in the unconfined compressive strength (UCS) of the soil up to a replacement ratio of 6%. However, higher replacement ratios resulted in a longer setting time of the binder. The bulk density of the soil decreased with increasing WWA content. Overall, the use of WWA as a cement replacement has the potential to enhance soil strength, but careful consideration of the replacement ratio is necessary to avoid negative effects on strength and setting time. Further research is needed to explore the impact of WWA on other geotechnical properties of the soil for a comprehensive evaluation of its suitability as a soil stabilization technique.
Downregulation of enhancer RNA AC003092.1 is associated with poor prognosis in kidney renal clear cell carcinoma
Authors: Chen Chen , Li Lili , Xiong Xi , Yuan Yuan , Yang Jun , Luo Pengcheng , Zhang Wei 
Published: September 2023

Abstract
Purpose: Kidney renal clear cell carcinoma (KIRC) is the most common histological type of renal cancer, enhancer RNA plays a significant role in tumor growth, however, it has been less studied in renal cancer. The aim of this study was to investigate the role of eRNA AC003092.1 in KIRC.
Methods：Clinical and RNA expression data were downloaded from a TCGA database, and performed bioinformatics analysis, including expression level analysis, survival analysis, clinical correlation analysis, immune correlation analysis. We further confirmed the expression level of AC003092.1 between normal and tumor cell, predicted the biological role of AC003092.1 in KIRC, and performed cell proliferation and wound healing assays, followed by GSEA enrichment analysis and western blot to detect the proteins of the enriched pathway.
Results: Bioinformatics results showed that AC003092.1 expression was elevated in tumor tissues, and knockdown of AC003092.1 expression inhibited cell proliferation and migration. GSEA and western blot results showed that knockdown AC003092.1 expression alleviated the extracellular matrix (ECM) process in KIRC cell lines.
Conclusion：Our study provides evidence that AC003092.1 play an important role in KIRC, and AC003092.1 may promote tumor cell progression by affecting the ECM process during tumor development.
Exogenous input autoregressive model optimization based on mixed variables for offline prediction CNC Swiss lathes thermal errors
Authors: Wu Shan , Kong Lingfei , Wang Aokun , Lu Qianhai , Feng Xiaoyang 
Published: September 2023

Abstract
Accurate prediction models of thermal errors are very useful for improving the machining accuracy of machine tools; it is also the core of thermal error compensation technology. Often, it is preferable to predict thermal deformation using the exogenous input autoregressive model, as opposed to computational inaccuracy and non-robustness existing in the static model. However, the autoregressive model needs to measure the thermal error online, which can be intrusive to the production process and reduce production efficiency. Previously, applying models to solving the engineering problem of machine thermal errors requires balancing accuracy and productivity. To simultaneously ensure prediction accuracy, robustness and productivity, this paper presents a new exogenous input autoregressive modeling approach based on mixed variables (MV-ARX) in CNC Swiss lathes. In addition, offline prediction is achieved by replacing online measurements with estimates of thermal errors. The effects of factors on thermal error, such as ambient temperature and spindle speed, are analyzed through thermal characteristic experiments. The K-means clustering method was used to select the thermal critical point, and the exogenous input autoregressive prediction model was optimized by combining the selected temperature variables with the spindle speed to improve the accuracy and robustness of offline prediction. The effectiveness of the proposed model is verified by comparing it with conventional models based on temperature-variable autoregression (TV-ARX) and multiple linear regression (MLR).
Foreign Ownership in Tax and Tunneling Incentive Relations - Transfer Pricing: The Case of a Multinational Company on the Indonesia Stock Exchange
Authors: Yuliana Indah , Rasheeda Salma , Nasikin Yayan , Ainiyah Faida 
Published: September 2023

Abstract
This study aims to analyze the direct relationship between tax and tunneling incentives with transfer pricing and moderation of foreign ownership in the relationship between tax and tunneling incentives and transfer pricing in multinational manufacturing companies in Indonesia. These results are useful for viewing company behavior in tunneling activities from a different perspective as well as for seeing companies with foreign ownership as vulnerable to transfer pricing and tunneling incentive transactions. The results of the study show that taxes and tunneling incentives simultaneously have an effect on transfer pricing, but partially tunneling incentives have no effect on transfer pricing and taxes have a positive effect on transfer pricing. Foreign ownership is able to moderate the effect of the tax variable on transfer pricing and foreign ownership is unable to moderate the effect of tunneling incentives on transfer pricing.
Compartmental intra-abdominal pressure risk in severe acute pancreatitis is prospectively assessed
Authors: Saad Hassan A. , Eraky Mohamed E. , El-Tahe¹ Ahmed K , Riad¹ Mohamed , Farid Mohamed I , Sharaf Khaled 
Published: September 2023

Abstract

Background
Hospital death is significant in patients with severe acute pancreatitis (SAP). These patients have elevated intraabdominal pressure (IAP), which may result in organ dysfunction. The goals of this study were to examine the overall incidence of rising IAP in patients with SAP, as well as the progression of organ dysfunction and risk of mortality factors for higher IAP.
Methods
Between 2020 and 2023, 118 cases of acute pancreatitis were managed in the intensive care unit of (University). Patients were categorized into quartiles 1–4. The intravesical technique was used to assess elevated IAP levels.
Results
Peak IAP, max SOFA score, max APACHE II score, top creatinine level, and age, with lactate peak level, were substantially related to IAP and were higher in nonsurvivors. The maximal IAP in retrospective groups 1–4 was 7–14, 15–18, 19–24, and 25–33 mmHg, respectively, with hospital mortality rates of 10%, 12.5%, 22.2%, and 50%, respectively. Respectively, the difference was statistically significant. The highest quality ICU-free days were 45.7, 38.8, 32.0, and 27.5 days, respectively. Categories one–four had significant statistical significance.
Conclusion
A greater IAP in SAP cases presented with early organ damage and fewer ICU-free days. IAP was assessed throughout ICU inpatient care to determine the cure rate after decompression.
Effect of host preference on bacterial microbiota of the bed bug species Cimex hemipterus
Authors: Mwamundela Baraka E. , Ismail Ashura M. , Mariën Joachim , Nzalawahe Jahashi S. , Mnyone Ladslaus L. 
Published: September 2023

Abstract
Bed bug infestations are growing globally as a result of increased travel, poor hygiene, and chemical resistance, making treatment more difficult. Like in other arthropods, understanding the bed bug gut microbiota composition can provide valuable insights for developing safe and effective control strategies by manipulating the bacteria found within. So far, little is known about how blood-meal sources impact the microbial compositions of bed bugs (Cimex hemipterus). We studied bed bug bacterial diversity after feeding on five host species: Humans, rats, mice, guinea pigs and bats. Bed bugs were fed on different blood sources every two days for 10 minutes, and DNA samples were extracted and analyzed using Illumina sequencing and the DADA2 pipeline method. The findings show that bacterial composition and diversity differed based on the blood-meal source, with only the Proteobacteria phylum consistently dominant across all bed bug samples (158011 sequences ), the most dominant genera were Wolbachia (136134 sequences, 86.15%) followed by Pectobacterium (21708, 13.74% sequences). The Wolbachia was found in three strains: Wolbachia1, Wolbachia2 and Wolbachia3. These represented 85.03% (134,367 sequences), 1.08% (1,701 sequences), and 0.04% (66 sequences) of the Wolbachia diversity in our samples. Furthermore, Salmonella with 158 (0.1%) sequences and Massilia with 11 (0.01%) sequences were the only pathogenic bacteria and were found in bed bugs fed on Guinea pigs and humans respectively. Our findings indicate that bed bugs feeding on humans have greater microbial diversity compared to those feeding on guinea pigs, rats, mice, or bats.
Exploration and research on ammonium free green leaching agent for ionic rare earth ore and influencing factors of soil slope stability
Authors: dengy yunchuan , Kang Shijie , Yang Jie , Yu Hongdong 
Published: September 2023

Abstract
This study analyzes the factors affecting the stability of soil slopes in the mining process of ammonium-free green leach of ionic rare earth ore through the research exploration related to ammonium-free green leach on the indoor similar simulation test, this paper sets up the research exploration of several ammonium-free green leach indoor similar simulation factors according to the role of soil particles, groundwater, etc., comparing and analyzing the role of ammonium-free green leach on seepage, time, and the role of precipitation on friction and cohesion. According to these three intrinsic influencing factors of ionic rare earth ore soil slope stability, combined with the relevant extrinsic influencing factors, the mine landslide was studied, which contributes to the exploration research of ammonium-free green leaching agent for ionic rare earth ore and analyzing influencing factors of soil slope stability, and provides an important theoretical basis for ammonium-free green, safe mining of ionic rare earth ore.
An Effective and Environmentally Friendly One-pot Multicomponent Approach for the Synthesis of spiroannulated hybrid molecules with Preferred Substructures using Indium Triflate as an efficient and Reusable Catalyst
Authors: Verma Asha , Kumar Sandeep , Khatri Vineeta , Pathak Gargi , Arya Dinesh Kumar 
Published: September 2023

Abstract
An Effective and Environmentally friendly, In(OTf)3 catalysed multicomponent approach to the synthesis of spiroannulated indolinequinolines, indoline pyridopyrimidines, chromeno pyridineindolines and indeno pyridineindolines has been presented the first time. The current approach uses an indium triflate catalyst in a one-pot four-component reaction of isatin, malononitrile, 1,3-Diketone, and 4-ethylaniline in ethyl alcohol. The current protocol presents multiple advantages that including operational simplicity with easy workup, moderate reaction conditions, shorter reaction times (25-40 min), excellent yields (85-96%) with superior atom economy, and environmentally friendly reaction conditions due to the use of recyclable, and non-hazardous catalyst.
Machine learning-based predictions and analyses of the creep rupture life of the Ni-based single crystal superalloy
Authors: Chen Yanzhan , Zhao Yaohua 
Published: September 2023

Abstract

The evaluation of creep rupture life is complex due to its variable formation mechanism. In this paper, machine learning algorithms are applied to explore the creep rupture life span as a function of 27 physical properties to address this issue. By training several classical machine learning models and comparing their prediction performance, XGBoost is finally selected as the predictive model for creep rupture life. Moreover, we introduce an interpretable method, Shapley additive explanations (SHAP), to explain the creep rupture life predicted by the XGBoost model. The SHAP values are then calculated, and the feature importance of the creep rupture life yielded by the XGBoost model is discussed. Finally, the creep fracture life is optimized by using the chaotic sparrow optimization algorithm. We then show that our proposed method can accurately predict creep properties in a cheaper and faster way than other approaches in the experiments. The proposed method can be used for the inverse design of alloys.
3D3C rainbow particle tracking velocimetry: improving depth resolution and velocity vector acquisition rate by using color space for a multi-cycle rainbow pattern
Authors: Takeyama Mao , Suto Hitoshi , Hattori Yasuo 
Published: September 2023

Abstract

Rainbow particle tracking velocimetry can be used to measure 3D3C flow velocity vectors with a single color camera. The particle depth position is calculated from the hue degree of a particle color. A liquid-crystal display (LCD) projector can be used conveniently as a light source of the color pattern in place of the spectral diffraction of white light. Another advantage of using an LCD projector is the ability to change the RGB components of the color pattern. In this study, the rainbow color pattern was modified to increase available color. Colors with the same hue degree but different saturations were used in the color pattern. Using color space enhanced positional resolution in the color change direction. The parameters of new color patterns were number of cycles, saturation continuity and range of color space. They were designed and their performances were compared. The effective resolution in color change direction enhanced 2.4 times from original patten (single cycle rainbow), and velocity vector acquisition rate improved, in particular, for the range of small amount movement per step. Graphical Abstract
Re-exploration of prognosis in type B thymomas: establishment of a predictive nomogram model
Authors: Zhao Ke , Liu Lei , Zhou Xiaoyun , Wang Guige , Zhang Jiaqi , Gao Xuehan , Yang Libing , Rao Ke , Guo Chao , Zhang Ye , Huang Cheng , Liu Hongsheng , Li Shanqing , Chen Yeye 
Published: September 2023

Abstract
Objective
To explore the risk factors for disease progression after initial treatment of type B thymomas using a predictive nomogram model.
Methods
A single-center retrospective study of patients with type B thymoma was performed. The Cox proportional hazard model was used for univariate and multivariate analyses. Variables with statistical and clinical significance in the multivariate Cox regression were integrated into a nomogram to establish a predictive model for disease progression.
Results
A total of 353 cases with type B thymoma were retrieved between January 2012 and December 2021. The median follow-up was 58 months (range: 1-128 months). The 10-year progression-free survival (PFS) was 91.8%. The final nomogram model included R0 resection status and Masaoka stage, with a concordance index of 0.880. Non-R0 resection and advanced Masaoka stage were negative prognostic factors for disease progression (p < 0.001). No benefits of postoperative radiotherapy (PORT) were observed in patients with advanced stage and non-R0 resection (p = 0.114 and 0.284, respectively).
Conclusion
The best treatment strategy for type B thymoma is the detection and achievement of R0 resection as early as possible. Long-term follow-up is necessary, especially for patients with advanced Masaoka stage and who have not achieved R0 resection. No prognostic benefits were observed for PORT.
Initial characterization of a transgenic mouse with overexpression of the human D1-dopamine receptor in the heart
Authors: Rayo-Abella Lina Maria , Jacob Hannes , Hofmann Britt , Schneider Sarah , Schindler Lisa , Keller Max , Buchwalow Igor B. , Jin CongYu , Panula Pertti , Dhein Stefan , Klimas Jan , Hadova Katarína , Gergs Ulrich , Neumann Joachim 
Published: September 2023

Abstract
Dopamine can exert effects in the mammalian heart via five different dopamine receptors. There is controversy whether dopamine receptors increase contractility in the human heart. Therefore, we have generated mice that overexpress the human D1-dopamine receptor in the heart (D1-TG) and hypothesized that dopamine increases force of contraction and beating rate compared to wild type mice (WT). In D1-TG hearts, we ascertained the presence of D1-dopamine receptors by autoradiography using [3H]SKF 38393. The mRNA for human D1-dopamine receptors was present in D1-TG hearts and absent in WT. We detected by in-situ-hybridization mRNA for D1-dopamine receptors in atrial and ventricular D1-TG cardiomyocytes compared to WT but also in human atrial preparations. We noted that in the presence of 10 µM propranolol (to antagonize β-adrenoceptors), dopamine alone and the D1- and D5-dopamine receptor agonist SKF 38393 (0.1 µM – 10 µM cumulatively applied) exerted concentration- and time-dependent positive inotropic effects and positive chronotropic effects in left or right atrial preparations from D1-TG. The positive inotropic effects of SKF 38393 in left atrial preparations from D1-TG led to an increased rate of relaxation and accompanied by and probably caused by an augmented phosphorylation state of the inhibitory subunit of troponin. In the presence of 0.4 µM propranolol, 1 µM dopamine could increase left ventricular force of contraction in isolated perfused hearts from D1-TG. In this model, we have demonstrated a positive inotropic and chronotropic effect of dopamine. Thus, in principle, the human D1-dopamine receptor can couple to contractility in the mammalian heart.