bluuebunny/crossref_metadata_2025_split huggingface dataset:
Changes in symmetric dimethylarginine and glomerular filtration rates in hyperthyroid cats undergoing radioiodine therapy
Authors: Van Vertloo Laura R , Palerme Jean-Sébastien , Miles Kristina G , Bourgois-Mochel Agnes , Jergens Albert E 
Published: March 2023

Objectives The aims of this study were to evaluate concentrations of symmetric dimethylarginine (SDMA) in hyperthyroid cats before and after radioiodine treatment, and to compare results with other variables used to assess kidney function in cats (creatinine, urine specific gravity [USG] and glomerular filtration rate [GFR] measured by renal scintigraphy). Methods Thirteen cats diagnosed with hyperthyroidism based on clinical signs and increased serum total thyroxine (TT4) were included in this prospective study. Study design included physical examination, complete blood count, serum chemistry, TT4, urinalysis and SDMA before treatment (T0) and at 1 month (T1) and 3 months post-treatment (T3). GFR was quantified by renal scintigraphy at T0 and T3. Results Median GFR decreased significantly from baseline (3.18 ml/kg/min; range 1.35–4.87) at T3 (2.22 ml/kg/min; range 1.81–3.42 [ P = 0.005]). While median creatinine and serum urea nitrogen increased post-treatment (creatinine: T0 = 0.8 mg/dl [range 0.4–1.1], T1 = 1.3 mg/dl [range 0.9–2]; T3 = 1.65 mg/dl [range 0.8–2.8]; P <0.001; serum urea nitrogen: T0 = 23 mg/dl [range 15–26]; T1 = 27 mg/dl [range 20–40]; T3 = 27.5 mg/dl [range 20–36]; P <0.001), SDMA and USG did not change significantly (SDMA: T0 = 11 µg/dl [range 7–15]; T1 = 12 µg/dl [range 6–16]; T3 = 10.5 µg/dl [range 8–21]; P = 0.789; USG: T0 = 1.030 [range 1.011–1.059]; T1 = 1.035 [range 1.012–1.044]; T3 = 1.030 [range 1.007–1.055]; P = 0.792). Conclusions and relevance Our data suggest that factors other than GFR may affect serum SDMA in hyperthyroid cats and that SDMA does not offer an advantage over other biomarkers traditionally used to predict changes in renal function following radioiodine therapy.
Synergistic Interactions of Insufficient Physical Activity and a High Systemic Immune-Inflammation Index on Psychological Problems in Indonesians With Type 2 Diabetes Mellitus
Authors: Rias Yohanes Andy , Tsai Hsiu Ting , Thato Ratsiri , Apriyanto Bagus Sholeh , Chou Kuei Ru , Ho Shu Chuan , Sun Chia Hsuan 
Published: March 2023

Background High-grade inflammation represents a critical contribution to the onset of depression and might be manageable by physical activity (PA). Nevertheless, no study has examined synergistic interactions of insufficient PA and high values of the systemic immune-inflammation index (SII) on psychological problems. Objective We investigated independent and synergistic interactions of insufficient PA and high SII levels on stress, anxiety, and depression in T2DM patients. Methods A cross-sectional research design with 294 T2DM patients was conducted. An XP-100 automated hematology analyzer was used to evaluate inflammatory biomarkers. Depression, Anxiety, and Stress Scale-21 items and a standardized questionnaire about PA were respectively used to measure psychological problems and metabolic equivalent of task (MET)-h/week. Results A multiple linear regression demonstrated that patients with insufficient PA were significantly more likely to have higher stress ( β = 1.84, 95% confidence interval (CI) = 1.03–2.65), anxiety ( β = 1.88, 95% CI = 1.81–2.96), and depression ( β = 2.53, 95% CI = 0.82–4.24) than those with active PA. A high SII level was a key predictor and was most strongly associated with stress ( β = 2.61, 95% CI = 2.02–3.20), anxiety ( β = 3.16, 95% CI = 2.37–3.94), and depression ( β = 3.72, 95% CI = 2.49–4.96) compared to those who had low SII levels. Notably, additive interaction results showed that combining insufficient PA and a high SII level had a significantly escalated 1.71-fold risk of stress, 1.82-fold risk of anxiety, and 2.69-fold risk of depression. Conclusions Active PA and a low SII had a positive synergistic effect of decreasing psychological problems.
Keratoconus in two siblings with congenital distichiasis
Authors: Dongre Pankaj , Bothra Nandini , Chaurasia Sunita 
Published: March 2023

Purpose To describe a previously unreported association of keratoconus in congenital distichiasis. Methods Observational case series of ocular findings in 2 siblings with congenital distichiasis. Results A 17-year-old male presented with tearing and photophobia in both eyes. His parents revealed that he was photophobic since birth. He had a lid surgery previously in both eyes. Clinical examination revealed a central scar with Descemet membrane tear suggestive of healed hydrops in the right eye. The left eye showed topographic features of keratoconus. His younger sibling, a 14-year-old female, also had similar symptoms of photophobia and tearing since birth. She had undergone electrolysis in both eyes. At the present visit, she had an epithelial defect with congestion in the right eye. Electrolysis of the distichiatic eyelashes was performed along with bandage contact lens application, which relieved her symptoms. Her topography revealed subclinical keratoconus in both eyes. The siblings’ father also had complaints of photophobia since birth and had lid surgery and electrolysis in the second decade of his life. Conclusions Patients with congenital distichiasis may have associated keratoconus. Chronic ocular irritation and subsequent eye rubbing in distichiasis could be the risk factor for keratoconus.
Direct anterior approach associated with lower dislocation risk after primary total hip arthroplasty in patients with prior lumbar spine fusion
Authors: Iturregui Jose M , Sebro Ronnie , Baranek Morgan , Garner Hillary W , Stanborough Rupert O , Goulding Krista A , Ledford Cameron K , Wilke Benjamn K 
Published: March 2023

Background: While there has been much interest in the increased dislocation rate in total hip arthroplasty (THA) patients with a lumbar spine fusion (LSF), there is minimal literature comparing the risk based on surgical approach. The purpose of this study was to determine if a direct anterior (DA) approach was protective against dislocation when compared to the anterolateral and posterior approaches in this high-risk patient population. Methods: A retrospective review was performed of 6554 THAs performed at our institution from January 2011 to May 2021. 294 (4.5%) patients had a prior LSF and were included in the analysis. The surgical approach, timing of LSF in relation to THA, vertebral levels fused, timing of THA dislocation, and the need for revision surgery were recorded for statistical analysis. Results: In total, 39.7.3% of patients underwent a DA approach (n = 117), 25.9% underwent an anterolateral approach ( n = 76), and 34.3% underwent a posterior approach ( n = 101). There was no difference in number of vertebral levels fused between groups (mean 2.5, all p > 0.05). There was a total of 13 (4.4%) THA dislocation events, with an average time from surgery to dislocation of 5.6 months (0.3–30.5 months). There were fewer dislocations in the DA cohort (0.9%) in comparison to both the anterolateral (6.6%, p = 0.036) and posterior groups (6.9%, p = 0.026). Conclusions: The DA approach demonstrated a significantly lower THA dislocation rate compared to both the anterolateral and posterior approaches in patients with a concomitant LSF.
Predicting and Analyzing Restenosis Risk after Endovascular Treatment in Lower Extremity Arterial Disease: Development and Assessment of a Predictive Nomogram
Authors: Chen Jinxing , Tang Yanan , Shen Zekun , Wang Weiyi , Hou Jiaxuan , Li Jiayan , Chen Bingyi , Mei Yifan , Liu Shuang , Zhang Liwei , Lu Shaoying 
Published: March 2023

Purpose: This study aimed to develop and internally validate nomograms for predicting restenosis after endovascular treatment of lower extremity arterial diseases. Materials and Methods: A total of 181 hospitalized patients with lower extremity arterial disease diagnosed for the first time between 2018 and 2019 were retrospectively collected. Patients were randomly divided into a primary cohort (n=127) and a validation cohort (n=54) at a ratio of 7:3. The least absolute shrinkage and selection operator (LASSO) regression was used to optimize the feature selection of the prediction model. Combined with the best characteristics of LASSO regression, the prediction model was established by multivariate Cox regression analysis. The predictive models’ identification, calibration, and clinical practicability were evaluated by the C index, calibration curve, and decision curve. The prognosis of patients with different grades was compared by survival analysis. Internal validation of the model used data from the validation cohort. Results: The predictive factors included in the nomogram were lesion site, use of antiplatelet drugs, application of drug coating technology, calibration, coronary heart disease, and international normalized ratio (INR). The prediction model demonstrated good calibration ability, and the C index was 0.762 (95% confidence interval: 0.691-0.823). The C index of the validation cohort was 0.864 (95% confidence interval: 0.801-0.927), which also showed good calibration ability. The decision curve shows that when the threshold probability of the prediction model is more significant than 2.5%, the patients benefit significantly from our prediction model, and the maximum net benefit rate is 30.9%. Patients were graded according to the nomogram. Survival analysis found that there was a significant difference in the postoperative primary patency rate between patients of different classifications (log-rank p<0.001) in both the primary cohort and the validation cohort. Conclusion: We developed a nomogram to predict the risk of target vessel restenosis after endovascular treatment by considering information on lesion site, postoperative antiplatelet drugs, calcification, coronary heart disease, drug coating technology, and INR. Clinical Impact Clinicians can grade patients after endovascular procedure according to the scores of the nomograms and apply intervention measures of different intensities for people at different risk levels. During the follow-up process, an individualized follow-up plan can be further formulated according to the risk classification. Identifying and analyzing risk factors is essential for making appropriate clinical decisions to prevent restenosis.
The relationship between preoperative opioid use and adverse events following total shoulder arthroplasty
Authors: Kingston Kiera A. , Qin Charles , Qin Mia , Strelzow Jason , Shi Lewis 
Published: March 2023

Introduction Few studies have analyzed the effect of preoperative opioid use on postoperative outcomes after total shoulder arthroplasty (TSA). Methods Patients undergoing TSA were identified in the Pearldiver Humana Claims Dataset and stratified by level of preoperative opioid use. Primary outcomes were 90-day complications, readmissions, and revision surgery. Chi-square test and ANOVA were used to evaluate categorical and continuous variables respectively. A multivariable logistic regression analysis and a sub analysis excluding fracture as a primary diagnosis were completed. Results 18,791 patients underwent aTSA and rTSA including 9933 opioid naïve patients, 3016 sporadic opioid users and 5842 persistent opioid users. Significant differences were found in complications (6.0% vs 6.1% vs 9.1%, p < .001), readmission (7.6% vs 8.2% vs 12.6%, p < .001), and revision procedures (1.1% vs 1.1% vs 2.3%, p < .001) which remained significant after excluding fractures. After adjusting for comorbidity burden, persistent opioid use was associated with increased likelihood of complications (OR 1.4, 1.2–1.6), readmission (OR 1.6, 1.5–1.8) and revision procedures (OR 1.9, 1.5–2.4). This association remained after excluding fractures. Conclusion Persistent preoperative opioid use is associated with increased risk of early postoperative complications, readmission, and revision surgery for patients undergoing shoulder arthroplasty.
The Frequency and Severity of Complications in Surgical Treatment of Osteochondral Lesions of the Talus: A Systematic Review and Meta-Analysis of 6,962 Lesions
Authors: Hollander Julian J. , Dahmen Jari , Emanuel Kaj S. , Stufkens Sjoerd A.S. , Kennedy John G. , Kerkhoffs Gino M.M.J. 
Published: March 2023

Objective The primary aim was to determine and compare the complication rate of different surgical treatment options for osteochondral lesions of the talus (OLTs). The secondary aim was to analyze and compare the severity and types of complications. Design A literature search was performed in MEDLINE (PubMed), EMBASE (Ovid), and the Cochrane Library. Methodological quality was assessed using the Methodological Index for Non-Randomized Studies (MINORS). Primary outcome was the complication rate per surgical treatment option. Secondary outcomes included the severity (using the Modified Clavien-Dindo-Sink Complication Classification System for Orthopedic Surgery) and types of complications. The primary outcome, the severity, and the sub-analyses were analyzed using a random effects model. A moderator test for subgroup-analysis was used to determine differences. The types of complications were presented as rates. Results In all, 178 articles from the literature search were included for analysis, comprising 6,962 OLTs with a pooled mean age of 35.5 years and follow-up of 46.3 months. Methodological quality was fair. The overall complication rate was 5% (4%-6%; treatment group effect, P = 0.0015). Analysis resulted in rates from 3% (2%-4%) for matrix-assisted bone marrow stimulation to 15% (5%-35%) for metal implants. Nerve injury was the most observed complication. Conclusions In 1 out of 20 patients treated surgically for an OLT, a complication occurs. Metal implants have a significantly higher complication rate compared with other treatment modalities. No life-threatening complications were reported.
Online counselling for family carers of people with young onset dementia: The RHAPSODY-Plus pilot study
Authors: Perin Stephanie , Lai Rhoda , Diehl-Schmid Janine , You Emily , Kurz Alexander , Tensil Maria , Wenz Michael , Foertsch Bettina , Lautenschlager Nicola T 
Published: March 2023

Objective Compared to late life dementia, Young Onset Dementia (YOD) has its own distinct challenges, including a lack of specialised and age-appropriate support services. Carers of people with YOD experience higher levels of psychological and physical symptoms, and lower quality of life. This study (RHAPSODY-Plus) assessed the acceptability and feasibility of combining RHAPSODY (Research to Assess Policies and Strategies for Dementia in the Young; a web-based information and skill-building programme for carers of people with YOD) with individually tailored support sessions with health professionals (a social worker and a clinical psychologist) provided via online videoconferencing. Methods Participants (n = 20) were informal carers aged over 18 years, who were caring for a person with YOD (either Alzheimer's disease or frontotemporal dementia type). Participants used the RHAPSODY programme for 4 weeks, then attended 2 support sessions. Participants and the health professionals then attended individual feedback sessions. Feedback was collected via open-ended and Likert-style questions. Results The majority of carers rated the RHAPSODY-Plus programme as good to very good, demonstrating a high level of acceptability. Positive feedback about the programme included being able to receive personal advice additionally to the information provided in RHAPSODY. The healthcare professionals also thought the programme was acceptable and beneficial for access to support. Some limitations in the feasibility of videoconferencing included network and technical issues and the loss of non-verbal communication. Conclusions This online pilot study had a high level of acceptability, demonstrating the potential of an individualised multi-modal intervention for carers of people with YOD which offers opportunities to overcome geographical and service access barriers.
Airway Complications After Anterior Cervical Spine Surgery: Etiology and Risk Factors
Authors: Colón Luis Felipe , Barber Lauren , Soffin Ellen , Albert Todd J. , Katsuura Yoshihiro 
Published: March 2023

Study Design Narrative Review Objective To provide an overview of etiology and risk factors of airway complications after anterior cervical spine surgery (ACSS). Methods A search was performed in PubMed and adapted for use in other databases, including Embase, Cochrane Library, Cochrane Register of Controlled Trials, Health Technology Assessment database, and NHS Economic Evaluation Database. Results 81 full-text studies were reviewed. A total of 53 papers were included were included in the review and an additional four references were extracted from other references. 39 papers were categorized as etiology and 42 as risk factors. Conclusions Most of the literature on airway compromise after ACSS is level III or IV evidence. Currently, there are no systems in place to risk-stratify patients undergoing ACSS regarding airway compromise or guidelines on how to manage patients when these complications do occur. This review focused on theory, primarily etiology and risk factors.
The Relationship Between Coping Strategies, Compassion Satisfaction, and Compassion Fatigue During the COVID-19 Pandemic
Authors: Abou Hashish Ebtsam Aly , Ghanem Atalla Amal Diab 
Published: March 2023

Introduction The rapid spread of COVID-19 poses a significant threat to nurses’ lives and health, resulting in varying degrees of mental distress. Nurses may experience compassion fatigue, and their professional quality of life and satisfaction may suffer as a result. Their coping mechanisms may vary as well, influencing their compassionate and safe care. Objectives The study's objectives are to explore levels of compassion satisfaction and fatigue among nurses and identify their coping strategies. Further, to investigate the relationship between coping strategies, compassion satisfaction, and compassion fatigue during the COVID-19 pandemic. Methods Using a descriptive correlational design, this study was conducted with a convenience sample of 443 nurses working in an Egyptian university hospital. Nurses completed the coping strategy indicator scale and the professional quality of life (compassion satisfaction and compassion fatigue) scale. The data were analyzed using descriptive statistics, Pearson correlation, and regression analysis. Results Nurses’ professional quality of life was average in terms of compassion satisfaction (2.95 ± 0.92) and compassion fatigue (2.38 ± 0.35). Nurses have a moderate use of coping strategies (2.13 ± 0.35). Problem-solving was rated as the highest coping strategy, while avoidance was rated as the lowest. Coping strategies showed a positive correlation with compassion satisfaction ( r = 0.503, p < .001) and a negative correlation with compassion fatigue ( r = −0.352, p < .001). In addition, coping strategies could predict 25.4% and 12.4% of compassion satisfaction and compassion fatigue, respectively ( p < .001). Conclusion Compassion satisfaction and fatigue are key determinants of nurses’ quality of work life. Coping strategies, especially problem-solving and support systems, are vital to increase compassion satisfaction and mitigate burnout and secondary stress syndrome. Nurse managers should establish supportive work environments that promote nurses’ well-being. Resilience-building programs and coping strategies’ training are recommended to enhance the nurses’ quality of work life and positive work attitudes.
Developing a national dataset of bicycle infrastructure for Canada using open data sources
Authors: Ferster Colin , Nelson Trisalyn , Manaugh Kevin , Beairsto Jeneva , Laberee Karen , Winters Meghan 
Published: March 2023

High-quality and consistent cycling infrastructure data are needed to advance research into equity and safety and for planning active transportation. With recent growth in cycling and investments in cycling infrastructure, there are concerns that these investments have not been equitable across communities. There is no consistent and complete national dataset for cycling infrastructure in Canada. Our goal is to develop a national cycling infrastructure dataset by (1) classifying OpenStreetMap (OSM) using the Canadian Bikeway Comfort and Safety Classification System (Can-BICS) as consistent criteria and categorisation for comfort class and infrastructure type; (2) performing a site-specific accuracy assessment by comparing the classification with more than 2000 reference points from a stratified random sample in 15 cities; and (3) presenting summary results from the national dataset. Based on reference data collected in 15 test cities, the classification had an estimated accuracy of 76 ± 3% for presence or absence of infrastructure, 71 ± 4% for comfort class and 69 ± 4% (by length) for infrastructure type. High comfort infrastructure was slightly underestimated (since bike paths were sometimes confused with multi-use paths) and low comfort infrastructure was slightly overestimated. Nationally, we identified 22,992 km of cycling infrastructure meeting Can-BICS standards and 48,953 km of non-conforming infrastructure. Multi-use paths are the most common infrastructure type by length (16.6%), followed by painted bike lanes (11.0%), and then high comfort infrastructure (cycle tracks, local street bikeways and bike paths) (4.3%). There was a wider range in access to cycling infrastructure in small cities than in medium and large cities. To reduce repeated effort assembling data and increase reproducible active transportation research, we encourage contribution to OSM.
Diagnostic options for pulmonary fungal diseases in Africa
Authors: Mushi Martha F. , Zaki Sherif M. , Penney Richard O.S. , Bamba Sanata , Ngouanom Kuate Marius Paulin , Kasamba Eric L. , Amona Fructueux M. , Werkneh Sara , Ceesay Buntung , Dibba Bakary , Ocansey Bright , Sy Ousmane , Yahaya Mohammed , Jiba Darlinda , Boyles Tom , Mkumbaye Sixbert I. , Kwizera Richard , Sibanda Elopy , Koffi David , Sissinto Savi De Tove Yolande , Orefuwa Emma , Denning David W. 
Published: March 2023

BackgroundFungal lung diseases are global in distribution and require specific tests for diagnosis. We report a survey of diagnostic service provision in Africa.MethodsA written questionnaire was followed by a video conference call with each respondent(s) and external validation. To disseminate the questionnaire, a snowball sample was used.ResultsData were successfully collected from 50 of 51 African countries with populations >1 million. The questionnaire was completed by respondents affiliated with 72 health facilities. Of these 72 respondents, 33 (45.8%) reported data for the whole country while others reported data for a specific region/province within their country. In the public sector, chest X-ray and computed tomography are performed often in 49 countries (98%) and occasionally in 37 countries (74%), and less often in the private sector. Bronchoscopy and spirometry were done often in 28 countries (56%) and occasionally in 18 countries (36%) in the tertiary health facilities of public sector. The most conducted laboratory diagnostic assay was fungal culture (often or occasionally) in 29 countries (58%). In collaboration with the Africa Centre for Disease Control and Prevention, regional webinars and individual country profiles provided further data validation.ConclusionThis survey has found a huge disparity of diagnostic test capability across the African continent. Some good examples of good diagnostic provision and very high-quality care were seen, but this was unusual. The unavailability of essential testing such as spirometry was noted, which has a high impact in the diagnosis of lung diseases. It is important for countries to implement tests based on the World Health Organization Essential Diagnostics List.