bluuebunny/crossref_metadata_2025_split huggingface dataset:
The interplay between social and food environments on UK adolescents’ food choices: implications for policy
Authors: Shaw Sarah , Muir Sarah , Strömmer Sofia , Crozier Sarah , Cooper Cyrus , Smith Dianna , Barker Mary , Vogel Christina 
Published: August 2023

Abstract
Factors from social and food environments can influence the food choices of adolescents in ways not experienced during childhood. Evidence suggests these two environments influence adolescents’ food choices independently, but there is limited knowledge of how the interplay between these environments influence adolescents’ diets. An enhanced understanding of this interplay surrounding adolescent food choice could aid the development of more nuanced interventions and policies. This qualitative study involved 13 online focus groups with adolescents (n = 45) aged 11–18 years, attending secondary school or college in England, UK. Data were analysed using thematic analysis. Social experiences which accompanied eating were perceived as more important than the food itself, and fast-food outlets were described as uniquely suited to facilitating these interactions. Young people wanted to spend their money on foods they considered worthwhile, but this did not always relate to the most affordable foods. Adolescents wanted to put little effort into making food decisions and appreciated factors that helped them make quick decisions such as prominent placement and eye-catching promotions on foods they wanted to buy. Chain food outlets were valued as they offered familiar and frequently advertised foods, which minimized the effort needed for food decisions. Adolescents’ sense of autonomy underpinned all themes. Participants described having limited opportunities to make their own food choices and they did not want to waste these buying unappealing ‘healthy’ foods. Interventions and government policies should align with adolescents’ experiences and values relating to food choice to ensure that they are effective with this important age group.
Defining the Roles of Inflammatory Bowel Disease Clinical Pharmacists in the United States: A Systematic Review and National RAND/UCLA Consensus
Authors: Bhat Shubha , Lyu Ruishen , Agarwal Mitali , Becker Michelle , Bloomfeld Richard , Bruining David H , Cohen Benjamin L , Ivanov Marina , Leighton Jonathan A , Stewart Alyssa P , Trocke Lindsay , Tse Stacy S , Ungaro Ryan C , Vaughn Byron P , Regueiro Miguel , Sokn Erick , Rieder Florian 
Published: August 2023

Abstract

Background
Given the complexity of inflammatory bowel disease (IBD) care, utilization of multidisciplinary teams is recommended to optimize outcomes. There is a growing recognition that clinical pharmacists should be an integral part of this care model. We sought to define the roles of IBD clinical pharmacists in the United States.

Methods
A national multidisciplinary expert panel of 12 gastroenterologists and clinical pharmacists practicing in IBD clinics was assembled. We used the RAND/University of California, Los Angeles appropriateness method, with a total of 281 statements generated based on a systematic literature review and expert opinion. Each statement was anonymously rated as appropriate, uncertain, or inappropriate in 2 rounds of voting.

Results
The number of publications evaluating the clinical pharmacists’ roles in IBD is limited, primarily focusing on thiopurine initiation and monitoring, medication adherence, and switching to biosimilars. Medication education; medication initiation and monitoring; therapeutic drug monitoring; biosimilar management; health maintenance review; and transitions of care were deemed by the panel to be appropriate roles for IBD clinical pharmacists. In considering real-world settings, IBD clinical pharmacists should practice clinically under a predefined scope and primarily focus on complex treatments (eg, immunomodulators, biologics, and small molecules). Clinical pharmacists should also be included in practice settings with IBD specialized physicians. Additionally, clinical pharmacists caring for patients with IBD should be residency trained and board certified.

Conclusions
This consensus defines IBD clinical pharmacists’ roles and provides a framework for embedded clinical pharmacists in IBD care.
Differentiation of Active Ulcerative Colitis vs Noninflammatory Bowel Disease Proctitis by Transperineal Superb Microvascular Imaging
Authors: Tokushima Kaori , Jimbo Keisuke , Suzuki Mitsuyoshi , Endo Yoshiko , Hibio Musashi , Maruyama Kimiko , Kashiwagi Kosuke , Arai Nobuyasu , Sato Masamichi , Kudo Takahiro , Hoshino Eri , Ohtsuka Yoshikazu , Shimizu Toshiaki 
Published: August 2023

Abstract

Background
Transabdominal ultrasonography and transperineal ultrasonography (TPUS) appear correspond to colonoscopy (CS) for evaluating ulcerative colitis (UC) activity, but their utility in UC diagnosis remains unclear. This research compared the accuracy of TPUS and CS for assessing rectal activity and differentiating noninflammatory bowel disease proctitis from UC in pediatric cases.

Methods
The study is a blinded, prospective, and controlled trial. Prospectively, values of fecal calprotectin (FCP) and findings of the TPUS and CS were compared between child cases of UC and non-IBD proctitis. Findings of rectal wall thickening (RWT), rectal wall flow (RWF) on power Doppler, and microvascular signal at wall circumference (MSWC) on monochrome superb microvascular imaging assessed using TPUS were compared with the CS.

Results
Thirty patients with Mayo endoscopic subscore (MES) 0 to 1 UC, 57 with MES 2 to 3 UC, and 44 with proctitis were registered. Fecal calprotectin, RWF, and MSWC indicated significant differences among the groups (P &lt; .05). Rectal wall thickening showed no significant difference between MES 0–1 and proctitis (P = .76). Rectal wall thickening and MSWC were independent predictors of endoscopic activity of UC, resulting in a sensitivity and specificity of 100% for RWT ≥4.5 mm and positive MSWC. Fecal calprotectin and RWF were independent predictors for differentiating MES 0 to 1 and proctitis, and FCP and RWT were independent predictors for differentiating MES 2 to 3 and proctitis. Sensitivity and specificity were 77.2% and 80.9%, respectively, for FCP &gt;242.5 μg/g and RWF negative; and they were both 100% for RWT &gt;4.1 mm and MSWC positive.

Conclusions
Transperineal ultrasonography with mSMI may enable the evaluation of rectal activity and differentiation of UC from non-IBD proctitis with accuracy comparable to endoscopy.
Learn to be green: FDI spillover effects on eco-innovation in China
Authors: Wu Lichao , Wang Lili , Lin Lan 
Published: August 2023

Abstract
Global knowledge flows are not only important in promoting economic activities but also in addressing global environmental issues. In order to examine the mechanisms of how firms in emerging economies can learn from global partners in finding solutions to environmental challenges, we explore a rich data set covering nearly 190,595 Chinese firms and analyze the knowledge flows that local firms received from foreign firms in developing eco-innovations. We examine both knowledge flows in the same industry and those in the up- and down-stream industries, and, in particular, provide a nuanced consideration around the under-explored industrial conditions and regional institutions of technology spillovers and domestic eco-innovation. We find clear evidence that foreign green technology spillovers have a positive impact on the eco-innovation of domestic firms in China. This superior performance is particularly pronounced in certain industries (e.g., technology-intensive, pollution-intensive, and highly competitive) and cities with higher levels of environmental regulation stringency. Our results show that domestic firms differ significantly in the extent to which they benefit from global knowledge flows.
Reflecting on the recent history of coastal Maine fisheries and marine resource monitoring: the value of collaborative research, changing ecosystems, and thoughts on preparing for the future
Authors: Waller J , Bartlett J , Bates E , Bray H , Brown M , Cieri M , Clark C , DeVoe W , Donahue B , Frechette D , Glon H , Hunter M , Huntsberger C , Kanwit K , Ledwin S , Lewis B , Peters R , Reardon K , Russell R , Smith M , Uraneck C , Watts R , Wilson C 
Published: August 2023

AbstractThe Maine Department of Marine Resources (MEDMR) is a state agency tasked with developing, conserving, researching, and promoting commercial and recreational marine fisheries across Maine’s vast coastline. Close collaborations with industry members in each of the 30 or more fisheries that support Maine’s coastal economy are central to MEDMR’s efforts to address this suite of tasks. Here we reflect on recent decades of MEDMR's work and demonstrate how MEDMR fisheries research programmes are preparing for an uncertain future through the lens of three broadly applicable climate-driven challenges: (1) a rapidly changing marine ecosystem; (2) recommendations driven by state and federal climate initiatives; and (3) the need to share institutional knowledge with a new generation of marine resource scientists. We do this by highlighting our scientific and co-management approach to coastal Maine fisheries that have prospered, declined, or followed a unique trend over the last 25+ years. We use these examples to illustrate our lessons learned when studying a diverse array of fisheries, highlight the importance of collaborations with academia and the commercial fishing industry, and share our recommendations to marine resource scientists for addressing the climate-driven challenges that motivated this work.
Comparative study on net-zero masonry walls made of clay and fly ash bricks and grouts/mortars/stuccos with the effect of super fine fly ash blended cement—low carbon cement
Authors: Kumar Prem , Nakkeeran G , Onyelowe Kennedy C , Krishnaraj L 
Published: August 2023

Abstract
In the construction sector, cement plays a vital role in all the members and components in which it acts as a binder and strength-dependent material. The production of cement material emits a large quantity of CO2 gas, which has been the main cause of global warming and other environmental and health issues. To overcome this issue, low carbon or net-zero cement production and utilization is a necessity, which equally satisfies the binder ability of conventional ordinary Portland cement (OPC). The fly ash from thermal power stations that is deposited in the yard is the most frequently used replacement material for cement. Due to its excellent pozzolanic properties, this fly ash can be utilized in place of binding materials in the building industry to achieve carbon neutrality. In this investigation, fly ash is used to prepare net-zero mortars in place of a significant amount of cement. Fly ash is utilized both in its natural form and after being ground into tiny particles for increased reactivity and effectiveness. The test for compressive strength allows for a detailed examination of the mechanical properties by altering the ratio of water to cement with and without the use of super plasticizer (SP). The best mortar is fine F fly ash (FFFA), which is made using a water-to-cement ratio of 0.4 + 1% SP. To validate the outcomes of this investigation, a characterization study of the improved mortars was examined.
Fractional Yamabe Problem on Locally Flat Conformal Infinities of Poincaré-Einstein Manifolds
Authors: Mayer Martin , Ndiaye Cheikh Birahim 
Published: August 2023

Abstract
We study the fractional Yamabe problem first considered by Gonzalez-Qing [36] on the conformal infinity $(M^{n}, \;[h])$ of a Poincaré-Einstein manifold $(X^{n+1}, \;g^{+})$ with either $n=2$ or $n\geq 3$ and $(M^{n}, \;[h])$ locally flat, namely $(M, h),$ is locally conformally flat. However, as for the classical Yamabe problem, because of the involved quantization phenomena, the variational analysis of the fractional one exhibits a local situation and also a global one. The latter global situation includes the case of conformal infinities of Poincaré-Einstein manifolds of dimension either $n=2$ or of dimension $n\geq 3$ and which are locally flat, and hence the minimizing technique of Aubin [4] and Schoen [48] in that case clearly requires an analogue of the positive mass theorem of Schoen-Yau [49], which is not known to hold. Using the algebraic topological argument of Bahri-Coron [8], we bypass the latter positive mass issue and show that any conformal infinity of a Poincaré-Einstein manifold of dimension either $n=2$ or of dimension $n\geq 3$ and which is locally flat admits a Riemannian metric of constant fractional scalar curvature.
Association of Gut Microbiota With Objective Sleep Measures in Women With and Without Human Immunodeficiency Virus Infection: The IDOze Study
Authors: Zhang Yanbo , Lin Chin Lun , Weber Kathleen M , Xing Jiaqian , Peters Brandilyn A , Sollecito Christopher C , Grassi Evan , Wiek Fanua , Xue Xiaonan , Seaberg Eric C , Gustafson Deborah , Anastos Kathryn , Sharma Anjali , Burgess Helen J , Burk Robert D , Qi Qibin , French Audrey L 
Published: August 2023

Abstract

Background
Poor sleep health is an underrecognized health challenge, especially for people with human immunodeficiency virus (HIV). Gut microbiota related to sleep are underinvestigated.

Methods
The IDOze microbiota substudy included 190 women (114 with HIV and 76 without HIV). Wrist actigraphy measured total sleep duration, sleep efficiency, number of wake bouts, wake after sleep onset, fragmentation index, and sleep timing. 16S rRNA gene sequencing identified gut microbial genera. Analysis of compositions of microbiomes with bias correction was used to investigate cross-sectional associations between gut microbiota and sleep. Abundances of sleep-related gut microbial genera were compared between women with and without HIV.

Results
Enrichment of 7 short-chain fatty acid–producing genera (eg, Butyricimonas, Roseburia, and Blautia) was associated with lower fragmentation index. Enrichment of 9 genera (eg, Dorea) was associated with lower sleep efficiency and/or more wake after sleep onset. Enrichment of proinflammatory Acidaminococcus was associated with late sleep midpoint and offset time. These associations were largely consistent regardless of HIV status. The abundance of Butyricimonas was lower among women with HIV compared to those without HIV.

Conclusions
Seventeen genera were identified to be associated with sleep continuity or timing. Butyricimonas, a potentially beneficial genus associated with sleep continuity, was less abundant among women with HIV.
Clinical and Immunologic Correlates of Vasodilatory Shock Among Ebola Virus–Infected Nonhuman Primates in a Critical Care Model
Authors: Stein Sydney R , Platt Andrew P , Teague Heather L , Anthony Scott M , Reeder Rebecca J , Cooper Kurt , Byrum Russell , Drawbaugh David J , Liu David X , Burdette Tracey L , Hadley Kyra , Barr Bobbi , Warner Seth , Rodriguez-Hernandez Francisco , Johnson Cristal , Stanek Phil , Hischak Joseph , Kendall Heather , Huzella Louis M , Strich Jeffrey R , Herbert Richard , St. Claire Marisa , Vannella Kevin M , Holbrook Michael R , Chertow Daniel S 
Published: August 2023

Abstract

Background
Existing models of Ebola virus infection have not fully characterized the pathophysiology of shock in connection with daily virologic, clinical, and immunologic parameters. We implemented a nonhuman primate critical care model to investigate these associations.

Methods
Two rhesus macaques received a target dose of 1000 plaque-forming units of Ebola virus intramuscularly with supportive care initiated on day 3. High-dimensional spectral cytometry was used to phenotype neutrophils and peripheral blood mononuclear cells daily.

Results
We observed progressive vasodilatory shock with preserved cardiac function following viremia onset on day 5. Multiorgan dysfunction began on day 6 coincident with the nadir of circulating neutrophils. Consumptive coagulopathy and anemia occurred on days 7 to 8 along with irreversible shock, followed by death. The monocyte repertoire began shifting on day 4 with a decline in classical and expansion of double-negative monocytes. A selective loss of CXCR3-positive B and T cells, expansion of naive B cells, and activation of natural killer cells followed viremia onset.

Conclusions
Our model allows for high-fidelity characterization of the pathophysiology of acute Ebola virus infection with host innate and adaptive immune responses, which may advance host-targeted therapy design and evaluation for use after the onset of multiorgan failure.
Transportability of bacterial infection prediction models for critically ill patients
Authors: Eickelberg Garrett , Sanchez-Pinto Lazaro Nelson , Kline Adrienne Sarah , Luo Yuan 
Published: August 2023

Abstract

Objective
Bacterial infections (BIs) are common, costly, and potentially life-threatening in critically ill patients. Patients with suspected BIs may require empiric multidrug antibiotic regimens and therefore potentially be exposed to prolonged and unnecessary antibiotics. We previously developed a BI risk model to augment practices and help shorten the duration of unnecessary antibiotics to improve patient outcomes. Here, we have performed a transportability assessment of this BI risk model in 2 tertiary intensive care unit (ICU) settings and a community ICU setting. We additionally explored how simple multisite learning techniques impacted model transportability.

Methods
Patients suspected of having a community-acquired BI were identified in 3 datasets: Medical Information Mart for Intensive Care III (MIMIC), Northwestern Medicine Tertiary (NM-T) ICUs, and NM “community-based” ICUs. ICU encounters from MIMIC and NM-T datasets were split into 70/30 train and test sets. Models developed on training data were evaluated against the NM-T and MIMIC test sets, as well as NM community validation data.

Results
During internal validations, models achieved AUROCs of 0.78 (MIMIC) and 0.81 (NM-T) and were well calibrated. In the external community ICU validation, the NM-T model had robust transportability (AUROC 0.81) while the MIMIC model transported less favorably (AUROC 0.74), likely due to case-mix differences. Multisite learning provided no significant discrimination benefit in internal validation studies but offered more stability during transport across all evaluation datasets.

Discussion
These results suggest that our BI risk models maintain predictive utility when transported to external cohorts.

Conclusion
Our findings highlight the importance of performing external model validation on myriad clinically relevant populations prior to implementation.
Technical note: Validation of energy dispersive X-ray fluorescence for determination of indigestible markers in ruminant fecal and rumen fluid samples
Authors: King Mindy E , Foote Andrew P 
Published: August 2023

Abstract
Determination of digestibility and passage rate is important for further understanding of nutrient utilization and thereby aids in improving nutrient utilization efficiency. Titanium dioxide and chromium ethylenediaminetetraacetic acid are commonly used as indigestible markers for determining passage rates of diets to aid in determination of digestibility. Analyzing Ti and Cr involves the use of procedures such as acid digestions, inductively coupled plasma spectroscopy, and atomic absorption. These commonly used methodologies involve hazardous chemicals, destruction of samples, and low sample throughput. The objective of this experiment was to develop and validate an accurate and precise method for measuring both Ti and Cr using energy dispersive X-ray fluorescence (ED-XRF). Energy dispersive X-ray fluorescence is an analytical technique used for analyzing elements in various sample types. The samples were added to the ED-XRF machine and irradiated with X-rays. The intensity of the X-rays emitted (termed fluorescent X-rays) was used for calculation of the concentration of the element. The method for Ti was constructed using fecal samples from cattle consuming three different diet types (finishing diet, dairy lactation diet, and grazing native range pasture). The Cr method was developed for rumen fluid analysis. We compared the machine-calculated concentrations of each element to the concentration calculated by a standard curve. For both the Ti and Cr, the standard curve-calculated value had a lower percent difference overall at 4.56% and 12.59%, respectively, compared to the machine percent difference of 8.35% and 16.38% for Ti and Cr, respectively. To determine accuracy and precision of the method, samples were spiked with various amounts of Ti or Cr and measured for their respective compounds with percent recovery and inter- and intra-assay CV-calculated thereafter. The average recovery for Ti across all diet types was 100.3%, and the recovery for Cr in rumen fluid was 95.7%. The average inter- and intra-assay CV for Ti, across all diet types, were 9.70% and 2.16%, respectively. For Cr, the average inter- and intra-assay CV were 5.42% and 8.45%, respectively. The ED-XRF method requires minimal additional chemicals, is cost-effective, and allows for sample preservation as well as a high throughput of samples. Our results indicate utilization of ED-XRF is an accurate and precise method for determination of Ti in feces and Cr in rumen fluid.
Conjugated linoleic acids inhibit lipid deposition in subcutaneous adipose tissue and alter lipid profiles in serum of pigs
Authors: Wang Liyi , Zhang Shu , Huang Yuqin , Zhou Yanbing , Shan Tizhong 
Published: August 2023

Abstract
Conjugated linoleic acids (CLAs) have served as a nutritional strategy to reduce fat deposition in adipose tissues of pigs. However, the effects of CLAs on lipid profiles in serum and how these lipid molecules regulate fat deposition are still unclear. In this study, we explored the effects of CLAs on regulating lipid deposition in adipose tissues in terms of lipid molecules and microbiota based on a Heigai pig model. A total of 56 Heigai finishing pigs (body weight: 85.58 ± 10.39 kg) were randomly divided into two treatments and fed diets containing 1% soyabean oil or 1% CLAs for 40 d. CLAs reduced fat deposition and affected fatty acids composition in adipose tissues of Heigai pigs via upregulating the expression of the lipolytic gene (hormone-sensitive lipase, HSL) in vivo and in vitro. CLAs also altered the biochemical immune indexes including reduced content of total cholesterol (TChol), high-density lipoprotein (HDL-C), and low-density lipoprotein (LDL-C) and changed lipids profiles including decreased sphingolipids especially ceramides (Cers) and sphingomyelins (SMs) in serum of Heigai pigs. Mechanically, CLAs may decrease peroxisome proliferator-activated receptorγ (PPARγ) expression and further inhibit adipogenic differentiation in adipose tissues of pigs by suppressing the function of Cers in serum. Furthermore, Pearson’s correlation analysis showed HSL expression was positively related to short-chain fatty acids (SCFAs) in the gut (P ≤ 0.05) but the abundance of Cers was negatively related to the production and functions of SCFAs (P ≤ 0.05). CLAs altered the distribution of the lipid in serum and inhibited adipogenic differentiation by suppressing the function of Cers and further decreasing PPARγ expression in adipose tissues of Heigai pigs. Besides, the HSL expression and the abundance of Cers are associated with the production and functions of SCFAs in the gut.