bluuebunny/crossref_metadata_2025_split huggingface dataset:
EVALUATION OF THE GEROPROTECTIVE EFFECT OF SQUALENE ON THE CAENORHABDITIS ELEGANS MODEL
Authors: Vesnina Anna D. , Dolganyuk Vyacheslav F. , Dmitrieva Anastasia I. , Loseva Anna I. , Milentyeva Irina S. 
Published: March 2023

Background. Increasing healthy life expectancy is a priority in modern healthcare. Squalene, a triterpene exhibiting antioxidant, anti-inflammatory and other properties, is a promising candidate for geroprotectors.
Purpose. Assess the activity of squalene, that is, the possibility of its further use as a geroprotector.
Materials and methods. Squalene was purchased from Sigma-Aldrich (USA) for research. Squalene solutions were prepared with concentrations of 10, 50, 100, 200, 400, 800, and 1600 µmol/L (solvent dimethyl sulfoxide—DMSO). The work was carried out on the basis of the Laboratory for Biotesting of Natural Nutraceuticals (KemGU, Russia). Antioxidant activity was assessed by capturing ABTS radical cations in comparison with the activity of ascorbic acid. The model organism Caenorhabditis elegans N2 Bristol was purchased from the Laboratory for the Development of Innovative Medicines and Agrobiotechnologies of the Moscow Institute of Physics and Technology. To assess the stress resistance of nematodes during cultivation, conditions of thermal (33°C) and oxidative (adding 15 μl of 1 M paraquat, 20°C) stress were created for 24 and 48 h. conditions (20 °C) for 61 days. The statistical significance of the results was assessed using Student’s t-test (in Microsoft Office Excel 2007). Lifespan data were assessed using a Kaplan-Meier survival plot combined with a log-rank test (Mantel-Cox). Data processing was carried out using the OASIS online application (https://sbi.postech.ac.kr/oasis/).
Results. The results showed that squalene solutions did not exhibit antioxidant properties; did not trap radical cations with ABTS. A solution of squalene at a concentration of 10 μM contributed to an increase in the stress resistance of nematodes. Under conditions of oxidative stress, the survival of nematodes during cultivation for 24 hours is 3.1% higher than in the control. Under conditions of heat stress during cultivation for 48 hours, the survival rate is higher by 11.3%. Squalene solutions did not affect the lifespan of nematodes.
Conclusion. Presumably, the antioxidant activity of squalene is expressed not in the capture of free radicals, but in the ability to act on biomolecules that lead to oxidative stress. A squalene solution with a concentration of 10 μM can reduce the negative impact of one of the factors causing premature aging. In order to assess the possibility of using squalene as a geroprotector without relying on cation-radical capture, further studies are needed to study the impact of the substance on other targets, mechanisms of action related to the occurrence of age-associated diseases. For example, analysis of the effect of squalene solutions on the growth rate of C. elegans larvae, the ability to influence the expression of antioxidant defense genes, the presence of anti-inflammatory and other properties.
Analysis of antibacterial and antioxidant potential of commercial essential oils from Tuzla markets
Authors: HoroziÄ‡ Emir , ImamoviÄ‡ Merima , BjeliÄ‡ Edita , SalkoviÄ‡ Vedad , KariÄ‡ Enida , HusejnagiÄ‡ Darja , AhmetoviÄ‡ Nihada 
Published: March 2023

Essential oils are natural products that contain a wide range of biologically active organic compounds. Therefore, they are intensively researched as potential antioxidant, antimicrobial and antitumor preparations, which could to some extent replace the classic synthetic drugs used to treat various pathological conditions. In this paper, the antioxidant and antibacterial activity of selected essential oils available in local markets in the area of Tuzla was examined. The efficiency of neutralization of free radicals was determined by spectrophotometric method, while the antibacterial potential was determined by diffusion technique on reference bacterial strains. For essential oils that showed antibacterial activity, the minimum inhibitory concentration (MIC) was determined using a dilution technique. The results showed that commercial essential oils have a high ability to neutralize DPPH radicals in vitro. The diffusion technique confirmed the high antibacterial activity for the essential oils of tea tree, eucalyptus, immortelle and wormwood, while the essential oils of lemon and cedar showed extremely weak antibacterial activity.Â Â
Involvement of venture capital companies in innovative companies
Authors: Elloumi Faiza , Ben Ammar Rania , Boujelbene Younes 
Published: March 2023

Previous work on venture capital proves an essential role for the investor, which goes beyond that of a simple proxy for funds. To better manage their investments, venture capital firms must specify the level of venture capital activism which fluctuates according to the composition of the completed investments, thus the investor is required to guarantee an appropriate contribution as a specific investor (EVCA, European Private Equity & Venture Capital Association, 2016). Studies on this subject show that the main characteristic of VCCs is their active involvement in the companies they finance. The aim is to target the intention and establish the satisfaction of business leaders with the in-kind contribution provided or imposed by venture capital firms. The organizational and decision-making structure of the company leads us to study the different perceptions taking into account the characteristics of SMEs and their great complexity. To achieve this goal, we conducted a questionnaire that we sent to several Tunisian companies financed by venture capital. This relationship between firms and venture capitalists can be visualized by the hypothesis results of our study. To ensure the reliability and accuracy of our work, we tried to take a sample that was very varied and included a fairly large number of companies.Â Â
A comparative study of parametric and semiparametric autoregressive models
Authors: Sapra Sunil 
Published: March 2023

Dynamic linear regression models are used widely in applied econometric research. Most applications employ linear autoregressive (AR) models, distributed lag (DL) models or autoregressive distributed lag (ARDL) models. These models, however, perform poorly for data sets with unknown, complex nonlinear patterns. This paper studies nonlinear and semiparametric extensions of the dynamic linear regression model and explores the autoregressive (AR) extensions of two semiparametric techniques to allow unknown forms of nonlinearities in the regression function. The autoregressive GAM (GAM-AR) and autoregressive multivariate adaptive regression splines (MARS-AR) studied in the paper automatically discover and incorporate nonlinearities in autoregressive (AR) models.Â Performance comparisons among these semiparametric AR models and the linear AR model are carried out via their application to Australian data on growth in GDP and unemployment using RMSE and GCV measures.Â Â
Petrography and geochemical framework of guÃ©bakÃ© dolerites dyke swarms (north Cameroon, central Africa)
Authors: Togo Abondou , Oumarou Faarouk Nkouandou , Tefogoum Ghislain Zangmo , Mefire Aminatou Fagny , Dawai Daouda , Appoliaire Dinamou , Dagwai Justin Guihdama , Haman Adama 
Published: March 2023

Dolerites dykes of 4.5 to 25 m wide extend from 200m to 1km, crosscut the GuÃ©bakÃ© granitoids basement in northern Cameroon along EW to N100E directions. Petrographic studies reveal the microlitic porphyritic texture to classical doleritic texture of ophitic to sub-ophitic types. GuÃ©bakÃ© dolerites are mainly composed in various proportions of skeletal plagioclase and feldspar, clinopyxene, amphibole and oxides crystals. ICP-MS and ICP-AES geochemical analyses have distiguished a lava series composed of trachybasalts, basaltic trachyandesites, trachyandesites, trachytes and rhyolites of continentale tholeiites affinity. Lavas have been differenciated trough fractional crystallization process coupled with crustal contamination and metasomatism. GuÃ©bakÃ© dolerites are products of relatively high partial melting rate of E-MORB mantle component. They stand as fingerprints of the post pan African crustal consolidation and precursor of the development of central African rift system at Cretaceous times.Â Â
Modeling of dielectric permittivity in the aggregation of erythrocyte molecules: application to deoxy-hemoglobin S
Authors: W. Akadry OlawolÃ© , L. Essoun AdÃ©bayo , Adomou A. , Massou S. 
Published: March 2023

In this paper, study of the impact of a new treatment approach in the aggregation kinetics of deoxy-hemoglobin S molecules is developed. New approach exploring mathematical model of dielectric permittivity of Davidson-Cole and takes into account several relaxation times of the dielectrics substances like blood. Results are such that, (i) only a fine analysis of intrinsic energy dissipation curves allow sufficient precision to be obtained to describe chronic hemolytic anemia due to sickle cell anemia based on the frequency of relaxation, (ii) hematocrit calculation by the formula allowed to show the uniqueness of the relaxation time of deoxy-hemoglobin S, (iii) hematocrit levels are low and the dispersion coefficient is the parameter most influential in the aggregation of hemoglobin S. From the analysis of all these results, it appears that, the mathematical model of Davidson-Cole is a good model interpretation and knowledge of sickle cell disease. The interest of this work is the understanding of the molecular mechanism that can help develop new treatment approaches capable of preventing or limiting the risk of complications of red blood cell diseases.Â Â
Study and design of a coconut stripper
Authors: Claude Vodounnou Edmond , Clarence Semassou Guy , H. Ahouansou Roger 
Published: March 2023

The predominance of the primary sector is noticeable in the economy of most African countries, particularly in Benin. Thus, to make this sector a vector of wealth and development, it is imperative to think about the development of technologies to improve the efficiency of processing and product quality. The mechanization of this sector is therefore necessary to make it more competitive. In Benin we have a lot of products which are made with the coconut. This sector has been relegated to a non-priority plan, whereas the coconut palm is a plant with a very considerable value like the oil palm, of which all the derived products are usable. It seems necessary to pass to the revival of this sector to help to stabilize the incomes of the small producers and traders in particular and to improve the commercial balance of the country in general. The maximization of the output of this sector directs towards the formula of Lavoisier: "nothing is lost, nothing is created, everything is transformed". The application of this formula allows us to transform the by-products of the said product. Currently, the de-shearing of the coconut is done manually with a cutter or with a pointed object. This way of making is too painful for producers who have large exploitations of coconut trees. In order to make this sector more profitable, our end-of-training work focuses on the study and design of a coconut de-sheathing machine intended to accompany coconut producers by reducing their pains and increasing their productivity in order to enhance the transformation of the said product.Â Â
Evaluation and suitability of a biomaterial as oil-based drilling fluids viscosifier using chemical structural properties approach
Authors: Uwaezuoke Nnaemeka , C. Igwilo Kevin , Oguamah Ifeanyi , C. Samuel George 
Published: March 2023

Mucuna solannie is a locally sourced material in Nigeria and other parts of Africa that enhances the viscosity of a drilling fluid. Due to its effectiveness, studies have been carried out on the structural properties of its seed flour for suitability as additive in oil-base mud. The chemical structures, name and other physiochemical properties of Mucuna solannie were determined using X-Ray Diffraction method, and the Fourier Transform Infrared Spectrometer. The scanned sample of Mucuna solannie was used to confirm the molecular bonding form, chemical structures and certain functional groups as basis of spectrum type. The result showed that Mucuna solannie was close to chitosan with covalent bonded molecular structure having calcium salt alone. It is a crystalline polymer and would require high calorific value to break the bonding energy existing in the molecules. Then, the FTIR discovered some functional groups and the position of carbon-carbon, carbon-hydrogen indicating the double bond.Â Â
Geomechanical effects of co2 storage in geological structures: two case studies
Authors: Soltanzadeh M. , Hakim SJS , Ibrahim MHW. , Shahidan S. , Mokhatar SN. , Lim AJMS 
Published: March 2023

Storage of CO2 in subsurface can assist to mitigate CO2 emission without extensively interfering with industrial activity and development. The main reason for geological storage to trap CO2 underground for a long time. However, the injection of CO2 may compromise the sealing characteristics of the caprock and, consequently, the containment of the underground CO2 storage unit as well. For instance, the injection of CO2 into a reservoir resulted in pore pressure and temperature changes leading to deformation and stress changes in the injection target and the rocks that surround it. These changes can influence the hydraulic integrity of the geological storage. The potential hazards could then impose different environmental, health, safety, and economic risks. Therefore, the geomechanical assessment of caprock integrity is critical for the storage of carbon dioxide. This research reviewed two different cases of underground CO2 storage in Canada and the workflows used for the assessment of geomechanical effects of CO2 injection on caprock integrity. It reviewed the processes of data collection, geomechanical characterization, and fluid flow modeling. These reviews highlighted the significance of geomechanical characterization and the fact that it is faced with significance challenges that could be addressed by data integration and geostatistical analysis. These reviewed studies implemented both analytical and numerical geomechanical models. While analytical models seem to be great choices for preliminary geomechanical analysis, numerical models are also necessary for a more detailed analysis.Â Â
Coronavirus disease 2019 in an elderly patient who became severely ill despite antibody cocktail therapy but improved with lung-protective management: A case report
Authors: Mitsutome Eriko , Une Kazunobu , Nakanuno Ryuichi 
Published: March 2023

Casilivimab/imdevimab, called antibody cocktail therapy, is a treatment for mildly and moderately ill COVID-19 patients. In our care facility, we encountered an elderly patient treated with an antibody cocktail after being diagnosed with a moderate disease at the initial presentation that became severe. An 80-year-old man with a history of diabetes, hypertension, and cerebral infarction presented with a 5-day history of fever and was diagnosed with coronavirus disease 2019. He was diagnosed with moderate disease and immediately ad-ministered the antibody cocktail therapy. However, his respiratory status deteriorated rapidly, and mechanical ventilation was initiated. We performed lung-protective ventilation, centered on low tidal volume and prone position therapy, with good outcomes. Throughout the pandemic, his case, as well as others, highlighted that immediate intervention for mild and moderate cases and intensive treatment, such as lung-protective ventilation and prone position, for severe cases improved patient outcomes.Â Â Â
Evaluating the protective impact of pumpkin seeds oil against ciprofloxacin induced hepatorenal toxicity in the male albino rats
Authors: Sabry Abd El-Shafi Ahmed Hanan , A. A.Elkomy Ashraf , A.H. Farag Enas 
Published: March 2023

Background: Ciprofloxacin increased the production of reactive oxygen species, As a result of its intracellular accumulation, which leads to extracellular membrane damage, resulting in the release of apoptotic components into the bloodstream, a condition known as apoptosis.Objective: The goal of this study is to investigate the protective effect of pumpkin seeds oil (PSO), a well-known natural antioxidant against Ciprofloxacin-induced liver and kidney impairment (CPFX[i]).Material and methods: Forty-Four male albino rats weighing approximately 180â€“200 gm were formed. (n = 10): (1) control saline, (2) PSO [ii] (4ml/kg/day orally for 4 weeks), (3) CPFX (80mg/kg/day orally for 2 weeks), and (4) PSO (4ml/kg/day orally for 4 weeks) + CPFX (80mg/kg/day orally for 2 weeks), starting on the first day of the third week. Finally, Serum and tissue specimens are collected at the conclusion of the experiment for biochemical and histopathological examination. Results: It ended up being found in the CPFX-treated group. ALT [iii], AST [iv], and TNFÎ±[v] levels were all significantly elevated in the serum. While this medication reduced the hepatocellular content of GSH [vi], it increased the tissue content of MDA [vii], which clearly shows oxidative stress Reduced BCL2[viii] levels also indicate the presence of apoptosis. CPFX causes an increase in kidney-specific markers such as creatinine and urea, indicating kidney disease. When PSO was combined with CPFX BAX [ix], MDA, AST, ALT, and TNFÎ± levels were considerably reduced, while GSH and BCL2 levels increased, indicating that PSO has antioxidant action and reduces apoptosis. Additionally, the renal function parameters improved, as seen by lower serum creatinine and urea levels.Conclusion: In rats, employing PSO as a concurrent prophylactic therapy while administering CPFX effectively reduced CPFX-induced oxidative stress and apoptotic damage. PSO could be used as a preventive medication to prevent CPFX-induced cellular damage to the kidneys and liver.Â Â Â
Software engineering's role in visualizing large data as medical datasets
Authors: Abdel Amir Sebti Hind , A. Najim Safa 
Published: March 2023

Although both 'information visualization' and â€˜software engineering visualization' are data collection operations, their motivations are clearly distinct. The visualization of software engineering integrates the original design modules and identifies the connections between the main components. The purpose of software engineering is to develop high-quality programs and create appropriate work. The goal of visualization is to get insight into many components of a process we are interested in, such as a scientific simulation or a real-world process, using interactive graphs. Medical imaging techniques are used to detect and comprehend illness progression in the human body. To be able to make a diagnosis concerning it. In health centers and hospitals, managing vast collections of medical pictures is a challenge. Because the image database has grown in size over the last year, meaningful information is needed to assist the specialist in assessing the patient's condition. In this review, we will highlight some of the techniques that we use in data analysis.Â Â Â
Peranan Taurin pada Pertumbuhan dan Kelangsungan Hidup Larva Ikan Kerapu Bebek Cromileptes altivelis (Valenciennes, 1828)
Authors: Melianawati Regina , Astuti Ni Wayan Widya , Tridjoko Tridjoko 
Published: March 2023

Taurine is an important amino acid for the growth of marine fish larvae The humpback grouper (Cromileptes altivelis) is a highly valuable marine fish that has been farmed in hactheries. The increasing of larval growth and survival rate of humpback grouper was carried out by taurine addition as enrichment ingredient to zooplankton as live feed for larvae. The purpose of this study was to find out the role of taurine on larval growth and survival rate. Two treatments tested were taurine addition by bioencapsulated through zooplankton rotifers Brachionus rotundiformis (A) and without taurine addition in rotifers (B). The observed parameters were larval growth and survival rate. Larval samples were taken on day 1 and 5, then continued every 5 days until the end of the study, by using10 larval samples at each time. The results showed that mostly all larvae have already metamorphosed and become juveniles at 35 days old. At that time, larvae with taurine addition (A) have bigger in size, faster growth and also higher survival rate compared than larvae without taurine addition(B). Therefore, the result of this study indicated that the addition of taurine could improve larval growth and the survival rate of humpback grouper. Taurin merupakan asam amino penting untuk pertumbuhan larva ikan laut. Ikan kerapu bebek (Cromileptes altivelis) adalah salah satu jenis ikan laut bernilai ekonomis tinggi yang sudah dapat dibudidayakan. Peningkatan pertumbuhan dan kelangsungan hidup larva ikan kerapu bebek dilakukan dengan penambahan taurin sebagai bahan pengkaya ke dalam zooplankton sebagai pakan alami larva. Tujuan penelitian ini adalah mengetahui peranan taurin pada pertumbuhan dan kelangsungan hidup larva. Dua perlakuan yang diujikan adalah penambahan taurin melalui bioenkapsulasi pada zooplankton rotifer Brachionus rotundiformis (A) dan tanpa penambahan taurin pada rotifer (B). Parameter yang diamati adalah pertumbuhan dan kelangsungan hidup larva. Sampel larva diambil pada umur 1 dan 5 hari, selanjutnya setiap 5 hari sekali hingga akhir penelitian, dengan menggunakan 10 ekor larva setiap waktu pengambilan sampel. Hasil penelitian menunjukkan bahwa sebagian besar populasi larva telah bermetamorfosis menjadi juvenil pada umur 35 hari. Pada umur tersebut, larva yang diberi penambahan taurin (A) memiliki ukuran yang lebih besar, pertumbuhan yang lebih cepat dan tingkat kelangsungan hidup yang lebih tinggi dibandingkan dengan larva yang tidak diberi penambahan taurin (B). Oleh karenanya, hasil penelitian ini menunjukkan bahwa penambahan taurin pada rotifer dapat meningkatkan pertumbuhan dan kelangsungan hidup larva ikan kerapu bebek.
Pain assessment 3 × 3: a clinical reasoning framework for healthcare professionals
Authors: Bäckryd Emmanuel 
Published: March 2023

Abstract

Objectives
To give an overview of central aspects of pain medicine-specific clinical reasoning when assessing a pain patient. Clinical reasoning is the thinking and decision-making processes associated with clinical practice.

Methods
Three core pain assessment areas that are crucial for clinical reasoning in the field of pain medicine are discussed, each of them consisting of three points.

Results
First, it is important to distinguish acute, chronic non-cancer, and cancer-related pain conditions. This classical and very simple trichotomy still has important implications treatment-wise, e.g., concerning the use of opioids. Second, the pain mechanism needs to be assessed. Is the pain nociceptive, neuropathic, or nociplastic? Simply put, nociceptive pain has to do with injury of non-neural tissue, neuropathic pain is caused by a disease or lesion of the somatosensory nervous system, and nociplastic pain is believed to be related to a sensitized nervous system (c.f. the concept of “central sensitization”). This also has implications concerning treatment. Some chronic pain conditions are nowadays viewed more as diseases rather than the pain being merely a symptom. In the new ICD-11 pain classification, this is conceptualized by the characterization of some chronic pains as “primary”. Third, in addition to a conventional biomedical evaluation, psychosocial and behavioral aspects must also be assessed, the pain patient being viewed as an active agent and not merely as the passive recipient of an intervention. Hence, the importance of a dynamic bio-psycho-social perspective. The dynamic interplay of biological, psychological, and social aspects must be taken into account, putative behavioral “vicious circles” thereby being identified. Some core psycho-social concepts in pain medicine are mentioned.

Conclusions
The clinical applicability and clinical reasoning power of the 3 × 3 framework is illustrated by three short (albeit fictional) case descriptions.