bluuebunny/crossref_metadata_2025_split huggingface dataset:
Green synthesis of silver nanoparticles via Taxus wallichiana Zucc. plant-derived Taxol: Novel utilization as anticancer, antioxidation, anti-inflammation, and antiurolithic potential
Authors: Bhusari Sachin , Sah Parvindar M. , Lakkakula Jaya , Roy Arpita , Raut Rajesh , Chondekar Ramesh , Alghamdi Saad , Almehmadi Mazen , Allahyani Mamdouh , Alsaiari Ahad Amer , Aljuaid Abdulelah , Al-Abdullah Nabeela 
Published: August 2023

Abstract
Throughout history, the utilization of plant products as medicinal remedies has been widespread, with numerous modern drugs finding their origins in the plant kingdom. Taxol, derived from Taxus species, stands out as an exceptional and highly potent anticancer medication. In this study, we present a rapid one-pot synthesis method for silver nanoparticles (AgNPs) using the leaves of Taxus wallichiana Zucca in the presence of sunlight. The synthesized AgNPs were comprehensively characterized using X-ray diffraction, transmission electron microscopy, and HPLC Q-TOF. The AgNPs were further investigated for their antioxidative, anticancer, anti-inflammatory, and antiurolithi properties. The anticancer activity was assessed through a sulforhodamine B assay conducted on the MDA-MB-231 human breast carcinoma cell line and SiHa human cervical cancer cell line. The findings of this study reveal the impressive antioxidative, anticancer, anti-inflammatory, and antiurolithi characteristics exhibited by AgNPs synthesized from leaf extracts. This research highlights an environmentally friendly and cost-effective approach to producing AgNPs by utilizing plant extracts as reducing agents, underscoring the immense potential of natural resources in advancing nanotechnology and its applications.
Intracellular spatially-targeted chemical chaperones increase native state stability of mutant SOD1 barrel
Authors: Ribeiro Sara S. , Gnutt David , Azoulay-Ginsburg Salome , Fetahaj Zamira , Spurlock Ella , Lindner Felix , Kuz Damon , Cohen-Erez Yfat , Rapaport Hanna , Israelson Adrian , Gruzman Arie-lev , Ebbinghaus Simon 
Published: August 2023

Abstract
Amyotrophic lateral sclerosis (ALS) is a progressive neurological disorder with currently no cure. Central to the cellular dysfunction associated with this fatal proteinopathy is the accumulation of unfolded/misfolded superoxide dismutase 1 (SOD1) in various subcellular locations. The molecular mechanism driving the formation of SOD1 aggregates is not fully understood but numerous studies suggest that aberrant aggregation escalates with folding instability of mutant apoSOD1. Recent advances on combining organelle-targeting therapies with the anti-aggregation capacity of chemical chaperones have successfully reduce the subcellular load of misfolded/aggregated SOD1 as well as their downstream anomalous cellular processes at low concentrations (micromolar range). Nevertheless, if such local aggregate reduction directly correlates with increased folding stability remains to be explored. To fill this gap, we synthesized and tested here the effect of 9 ER-, mitochondria- and lysosome-targeted chemical chaperones on the folding stability of truncated monomeric SOD1 (SOD1bar) mutants directed to those organelles. We found that compound ER-15 specifically increased the native state stability of ER-SOD1bar-A4V, while scaffold compound FDA-approved 4-phenylbutyric acid (PBA) decreased it. Furthermore, our results suggested that ER15 mechanism of action is distinct from that of PBA, opening new therapeutic perspectives of this novel chemical chaperone on ALS treatment.
Harris hawks optimization algorithm for load frequency control of isolated multi-source power generating systems
Authors: Karnavas Yannis L. , Nivolianiti Evaggelia 
Published: August 2023

Abstract
This paper presents a recent bio-inspired optimization algorithm for the critical topic of load frequency control (LFC) in an isolated multi-source power generating system. A specific model that emerges from the scientific literature and consists of reheated thermal, hydro and gas-turbine power sources is examined. The main goal is to tune the controller of each generating source i.e. find their optimal gains through bio-inspired optimization algorithms. Namely, the algorithms applied are the Whale Optimization Algorithm (WOA), Grey Wolf Optimizer (GWO), Particle Swarm Optimization (PSO), and the newly proposed Harris Hawks Optimization (HHO). It was observed that all optimization algorithms succeeded in obtaining controllers’ gain values which ensure stable system operation. Also, the simulation results indicated the superiority of the proposed HHO algorithm over the other algorithms for all the considered scenarios. In this article, for the first time to the authors’ knowledge extend an attempt has been made to optimize an isolated multi-source system using the bio-inspired HHO algorithm. The present study considered the LFC problem with a variety of different scenarios, taking into account both sub-cases of nonlinearities (e.g., generation rate constraint, boiler dynamics, etc.) and their combinations, as well as combinations of different controllers and load disturbances, which are not found in the literature. Last but not least, the robustness of the selected controller was further evaluated. The obtained results clearly demonstrated that the controller’s gains established in normal conditions do not require retuning when critical system parameters undergo a significant variation.
Effects of osmotic dehydration pretreatment on the drying and characteristics of pineapple slices after microwave hot air rolling bed drying
Authors: Li Guohua , Wang Bo , Du Zhilong , Li Mengge , Lv Weiqiao 
Published: August 2023

Abstract
This study aimed to investigate the effects of osmotic dehydration (OD) pretreatment on the drying and quality of pineapple slices dehydrated using microwave hot air rolling bed drying method. The result suggested the OD pretreatment significantly reduced the moisture content of the food material before drying. It also slightly increased the moisture ratio decreasing rate in the early stage of drying based on the formation of microchannels during the pretreatment. The pretreatment also increased overall temperature and facilitated the transition of free water to bounded water during drying. Based on the pretreatment, the undesired browning of pineapple slices during drying was significantly inhibited. However, the OD pretreatment with 60 % (w/v) sucrose solution caused significant dehydration of the sample before drying, finally resulting in more dramatic browning. Compared with the sample without OD pretreatment, the dried pretreated pineapple slices exhibited an increased amount of collapsed cell structures and pores, due to the cell deformation and water diffusion during the pretreatment. These microstructure changes finally contributed to their increased hardness, springiness and chewiness. Although the pretreatment caused a slightly higher ascorbic acid loss in the final dried food materials, the product with an improved sugar-to-acid ratio was prepared, indicating its improved acceptability. Considering the overall characteristics profile of the dried pineapple slices, the OD pretreatment using 50 % sucrose solution for 24 h was the optimum condition to develop promising dried pineapple slices products.
The gelation mechanism of mung bean starch as affected by edible alum
Authors: Gu Yue , Li Qingyun , Yang Yisu , Yang Xi 
Published: August 2023

Abstract
To understand the gelation mechanism of mung bean starch (MBS) as affected by addition of edible alum, the physicochemical properties of MBS gels and their gelation process under 0–0.25 % of alum addition were studied. The results showed that alum incorporation enhanced the gel texture and starch-water interaction in a concentration-dependent manner. With increasing amount of alum addition, the pH value and ζ-potential of MBS decreased, while the swelling power, pasting viscosity, the leached amylose content, gelation temperature, short-range ordered structure and the crystallinity of MBS gels increased. It is believed that alum addition improved the texture of MBS gels by promoting amylose leaching, starch aggregation and recrystallization. The increase in starch-water interaction might be due to the destruction of MBS structure by polar ions and the formation of clathrates by leached amylose and Al3+ ions.
Influence of flexoelectric effect on the bending rigidity of a Timoshenko graphene-reinforced nanorod
Authors: Nevhal Subhash K. , Gupta Madhur , Kundalwal Shailesh I. 
Published: August 2023

Abstract
The focus of this work is to study the influence of flexoelectric phenomenon on the electromechanical response of graphene-reinforced nanocomposite (GNC) nanorods. An analytical model has been derived by utilizing the Timoshenko beam theory and the principle of variational work by incorporating flexoelectric effects. The GNC nanorod is subjected to a concentrated load acting downward for clamped-free and simply supported support types. The GNC is reinforced with a defective graphene sheet as it is known to show enhanced polarization. The elastic properties of defective graphene sheets have been evaluated using molecular dynamic simulations. The outcome of our model shows that the flexoelectric effect must be considered for accurate modeling of nanostructures. Irrespective of the support type, flexoelectric effect improves the stiffness of the nanorod. We also observed that the stiffness of the nanorod is significantly influenced by the support type. This work presents an opportunity for the development of high-performance graphene-based nanoactuators/sensors.
Taste the feeling: an ecolinguistic analysis of Coca-Cola advertising
Authors: Stibbe Arran 
Published: August 2023

Abstract
This article presents an ecolinguistic framework for analysing advertising and applies it to a wide range of TV advertisements for Coca-Cola. This particular product was selected because of well-publicised criticisms of its impact on health and the environment. The framework classifies advertisements into one of five types: classic-type, identity-type, narrative-type, cause-type, and counter-type, with many advertisements being hybrids of more than one type. The analysis uses multimodal discourse analysis to reveal underlying messages behind the advertisements, and judges these according to an ecosophy based on the World Health Organisation’s concept of One Health. The aim of the analysis is to reveal linguistic and multimodal features that are used to persuade people to purchase products which potentially harm both the consumer and the environment. The results can be practically applied in critical language awareness materials that can promote healthier and more environmentally beneficial purchasing.
Study to compare the effect of casirivimab and imdevimab, remdesivir, and favipiravir on progression and multi-organ function of hospitalized COVID-19 patients
Authors: Hegazy Sahar K. , Tharwat Samar , Hassan Ahmed H. 
Published: August 2023

Abstract
Coronavirus disease 2019 (COVID-19) caused a progress in research to find a solution to this pandemic. Also, various advances in pharmacotherapy against COVID-19 have emerged. Regarding antiviral therapy, casirivimab and imdevimab are antibodies combination against COVID-19. Standard antiviral therapy against COVID-19 includes remdesivir and favipiravir. The objectives were to compare progression and multi-organ function of hospitalized COVID-19 patients between these three antiviral groups. 265 COVID-19 hospitalized patients were included in this study and were divided into 3 groups (1:2:2), respectively, Group (A): casirivimab and imdevimab, group (B): remdesivir, and group (C): favipiravir. The design of the study is a single blind non-randomized controlled trial. This study is a phase IV clinical trial (post-marketing study). The duration of the study was about 6 months after receiving the ethical approval. Casirivimab and imdevimab achieved less case progression as presented by lower World Health Organization scale (P < 0.05 in comparing group A with B and C) and better multi-organ functions as presented by lower Sequential Organ Function Assessment score (P < 0.05 in comparing group A with B and C) than remdesivir and favipiravir. From all these results, it is concluded that Group A (casirivimab and imdevimab) produces better outcomes than B (remdesivir) and C (favipiravir) intervention groups.
Correlation between microvessel maturity and ISUP grades assessed using contrast-enhanced transrectal ultrasonography in prostate cancer
Authors: Gao Yong , Zeng Xuerong , Liao Xinhong 
Published: August 2023

Abstract
This study aimed to assess the correlation among the peak intensity (PI) values of quantitative parameters, microvessel density (MVD), microvessel maturity, and International Society of Urological Pathology (ISUP) grades in biopsy specimens from prostate cancer (PCa) patients. The study population included PCa patients who underwent targeted and systematic biopsy, without radiation or chemohormonal therapy before biopsy. Contrast-enhanced transrectal ultrasonography (CE-TRUS) was performed in all patients before biopsy. Contrast-enhancement patterns and PI values of quantitative parameters were observed. Tumor tissue samples were immunostained for CD31 expression. MVD, microvessel maturity, and ISUP grades were determined in prostate biopsy specimens. Based on the contrast enhancement patterns of prostate lesions, 16 patients were assigned to a low-enhancement group and 45 to a high-enhancement group. The number of mature vessels, MVD, mature vessel index, and ISUP grades were all higher in the high-enhancement group than in the low-enhancement group (all P < 0.05). The immature vessel index was lower in the high-enhancement group than in the low-enhancement group (P < 0.05). The PI value was positively correlated with the number of mature vessels (r = 0.372). In conclusion, enhancement patterns on CE-TRUS can reflect microvessel maturity in PCa. The PI value was positively correlated with the number of mature vessels.
The crystal structure of the co-crystal 1,4-dioxane–4,6-bis(nitroimino)-1,3,5-triazinan-2-one(2/1), C11H19N7O9
Authors: Guannan Zhao , Tong Zhang , Jun Chen , Hongxia Pan , LiZhen Chen , Jianlong Wang 
Published: August 2023

Abstract
C11H19N7O9, orthorhombic, P212121 (no. 19), a = 6.2578(2) Å, b = 15.4188(5) Å, c = 17.6841(7) Å, V = 1706.30(1) Å3, Z = 4, Rgt
(F) = 0.0428, wRref
(F
2) = 0.0972, T = 100 K.
Adsorption of Th(IV) ions from aqueous solutions by ZnO functionalized graphene oxide
Authors: Kaptanoglu Ikbal Gozde , Yusan Sabriye 
Published: August 2023

Abstract
Graphene oxide (GO) and zinc oxide (ZnO) were synthesized via the Tour’ and sol-gel methods, respectively. Adsorption potentials of Th(IV) ions were investigated with the functionalization of GO with ZnO nanoparticles (GO-ZnO) and compared with the GO. Studies concerning factors affecting the adsorption process, kinetics, adsorption isotherms, and thermodynamic properties were carried out. In this study, the optimum pH for the adsorption of Th(IV) ions is 3.0, and quickly reaching equilibrium is an indication of the high efficacy of the sorbent. A pseudo-second order adsorption model fits the kinetic data well. Experimental results were compared with Langmuir, Freundlich, and Dubinin–Radushkevich isotherm models. These results show that the Langmuir model fits the data well. Measured thermodynamic parameters, Gibbs free energy change (ΔG°), enthalpy change (ΔH°), and entropy change (ΔS°) indicate that the adsorption of Th(IV) on GO−ZnO is spontaneous and endothermic in nature. According to the linear fit in the Langmuir isotherm model, the maximum adsorption capacity of GO and GO-ZnO at 298 K occurs at 109.89 mg/g and 243.90 mg/g, respectively. The results show that decoration with ZnO nanoparticles is a good method to improve the adsorption capacity of GO for Th(IV) removal.
Interneuron-Targeted Disruption ofSYNGAP1Alters Sensory Representations in the Neocortex and Impairs Sensory Learning
Authors: Zhao Meiling , Kwon Sung Eun 
Published: August 2023

SYNGAP1haploinsufficiency in humans leads to severe neurodevelopmental disorders characterized by intellectual disability, autism, epilepsy, and sensory processing deficits. However, the circuit mechanisms underlying these disorders are not well understood. In mice, a decrease of SynGAP levels results in cognitive deficits by interfering with the development of excitatory glutamatergic connections. Recent evidence suggests that SynGAP also plays a crucial role in the development and function of GABAergic inhibitory interneurons. Nevertheless, it remains uncertain whether and to what extent the expression ofSYNGAP1in inhibitory interneurons contributes to cortical circuit function and related behaviors. The activity of cortical neurons has not been measured simultaneously with behavior. To address these gaps, we recorded from layer 2/3 neurons in the primary whisker somatosensory cortex (wS1) of mice while they learned to perform a whisker tactile detection task. Our results demonstrate that mice with interneuron-specificSYNGAP1haploinsufficiency exhibit learning deficits characterized by heightened behavioral responses in the absence of relevant sensory input and premature responses to unrelated sensory stimuli not associated with reward acquisition. These behavioral deficits are accompanied by specific circuit abnormalities within wS1. Interneuron-specificSYNGAP1haploinsufficiency increases detrimental neuronal correlations directly related to task performance and enhances responses to irrelevant sensory stimuli unrelated to the reward acquisition. In summary, our findings indicate that a reduction of SynGAP in inhibitory interneurons impairs sensory representation in the primary sensory cortex by disrupting neuronal correlations, which likely contributes to the observed cognitive deficits in mice with pan-neuronalSYNGAP1haploinsufficiency.SIGNIFICANCE STATEMENTSYNGAP1haploinsufficiency leads to severe neurodevelopmental disorders. The exact nature of neural circuit dysfunction caused bySYNGAP1haploinsufficiency remains poorly understood. SynGAP plays a critical role in the function of GABAergic inhibitory interneurons as well as glutamatergic pyramidal neurons in the neocortex. Whether and how decreasingSYNGAP1level in inhibitory interneurons disrupts a behaviorally relevant circuit remains unclear. We measure neural activity and behavior in mice learning a perceptual task. Mice with interneuron-targeted disruption ofSYNGAP1display increased detrimental neuronal correlations and elevated responses to irrelevant sensory inputs, which are related to impaired task performance. These results show that cortical interneuron dysfunction contributes to sensory deficits inSYNGAP1haploinsufficiency with important implications for identifying therapeutic targets.
Knowledge of Chronic Obstructive Pulmonary Diseases among Healthcare Workers: Nigerian COPD Research Project (NICORP)
Authors: Omotola Ogunkoya John , John Sodeinde Kolawole , Temitope Okwudishu Oluyemisi , Emmanuel Ladele Akindele , Olufemi Osinaike Abiodun , Emmanue Bamidele Fikayo , Tobore Imishue Onome , Olufemi Solaja Taiwo 
Published: August 2023

Background: Chronic obstructive pulmonary disease (COPD) is a preventable and treatable chronic inflammatory lung disease that often causes obstruction to airflow in the lungs. The main risk factor in Nigeria is long term exposure to indoor pollution from cooking with firewood and fossil fuel in poorly ventilated spaces. Aims/ objectives: The aim was to evaluate the level of COPD knowledge among healthcare workers (HCWs) in the southwestern state of Nigeria.Materials/ methods: Self-administered online BCKQ which is made up of 65 stem questions was used to evaluate the level of knowledge of HCWs. The overall score of individual participants was represented in percentages and frequencies. Tests of statistical significance like the Chi-square test are applied to find out the statistical significance of the difference in percentages. Univariate analysis was done using respondent knowledge about COPD as the dependent variable and the socio-demographic were identified as independent variables. A p-value of <0.05 was taken as statistically significant in the calculations of variables. Results: Four hundred and five healthcare workers were involved in this study, 53.3% of whom were females. The mean age of the study cohort was 48.7±0.55 years, significant majority (75.6%) of whom were <40 years. (p< 0.001). Majority of cohorts (39.3%) were doctors, while 32.0% were nurses. Only 11.7% had PhD or Fellowship as their highest educational qualification. The overall mean total score of cohorts on the Bristol COPD questionnaire was 51.9±21.9 %, with 40.4% having good scores and only 11.3% had excellent score. Mean knowledge scores were high among doctors (69.9±02.4), HCWs with medical fellowships /PhD (69.9±02.4) and had worked for <10 years. A positive correlation was demonstrated between age, level of education and knowledge score (p<0.05). Conclusion: This study examined knowledge of COPD among healthcare workers in the southwestern part of Nigeria and confirmed that the knowledge of COPD among healthcare workers was essentially good but there were serious gaps in knowledge observed in areas of vaccination, inhalational therapy, and use of inhaled and oral steroid.
Evaluación de Algamix® y dos porcentajes de drenaje en chile dulce (Capsicum annuum) cultivado en invernadero
Authors: Monge Pérez José Eladio , Loáiciga Arias Julio César , Loría Coto Michelle 
Published: August 2023

La aplicación de bioestimulantes y el uso de diversos porcentajes de drenaje pueden afectar la producción en la agricultura protegida. Se evaluó el efecto de la aplicación del bioestimulante Algamix® (vía foliar, vía radicular, y testigo) y dos porcentajes de drenaje (10 % y 30 %) sobre el rendimiento y la calidad del chile dulce cv. Nathalie cultivado bajo invernadero. Las variables evaluadas fueron: altura de planta (cm), diámetro de tallo (mm), número de frutos por planta, peso del fruto (g), rendimiento (ton/ha), y porcentaje de sólidos solubles totales (°Brix). La aplicación del bioestimulante no produjo diferencias estadísticamente significativas en ninguna de las variables, excepto en el rendimiento de frutos de tercera calidad, donde las plantas que recibieron la aplicación foliar del bioestimulante produjeron un menor rendimiento, en relación con el testigo. En comparación con las plantas que tuvieron un 30 % de drenaje, las plantas con un 10 % de drenaje presentaron: una menor cantidad de frutos por planta y un menor rendimiento, en el caso de primera calidad; una mayor cantidad de frutos por planta y un mayor rendimiento, en el caso de tercera calidad; un menor peso del fruto (total y de primera calidad); y un menor porcentaje de sólidos solubles totales del fruto. La aplicación del bioestimulante no mejoró ni el rendimiento ni la calidad del chile dulce, por lo que no se recomienda su uso, bajo las condiciones en que se realizó el estudio. Se recomienda el uso de un drenaje del 30 % en chile dulce cultivado en invernadero, dado que produjo el mayor rendimiento de frutos de primera calidad.