bluuebunny/crossref_metadata_2025_split huggingface dataset:
Α rare case of myopathy, lactic acidosis, and severe rhabdomyolysis, due to a homozygous mutation of the ferredoxin‐2 (FDX2) gene
Authors: Gkiourtzis Nikolaos , Tramma Despoina , Papadopoulou‐Legbelou Kyriaki , Moutafi Maria , Evangeliou Athanasios 
Published: August 2023

AbstractMitochondrial myopathy is a severe metabolic myopathy related to nuclear or mitochondrial DNA dysfunction. We present a rare case of mitochondrial myopathy, presented with multiple episodes of proximal muscle weakness, lactic acidosis, and severe rhabdomyolysis (CPK 319,990 U/L, lactic acid 22.31 mmol/L, and GFR 3.82 mL/min/1.73m2). She was hospitalized in the pediatric intensive care unit due to acute kidney injury, elevated blood pressure, and deterioration of respiratory and cardiac function. Investigation for inherited metabolic disorders showed elevated levels of ammonia, lactic acid to pyruvic acid ratio, and urine ketone bodies. Exome sequencing detected a homozygous pathogenic variant in FDX2 (ENST00000541276:p.Met4Leu/c.10A > T) and a heterozygous variant of uncertain significance in MSTO1 (ENST00000538143:p.Leu137Pro/c.410 T > C). After Sanger sequencing, the p.Met4Leu pathogenic variant in FDX2 (ENST00000541276:p.Met4Leu/c.10A > T) was identified in a heterozygous state in both her parents and sister. Recently, pathogenic variants in the FDX2 gene have been associated with mitochondrial myopathy, lactic acidosis, optic atrophy, and leukoencephalopathy. Only four reports of FDX2‐related rhabdomyolysis have been described before, but none of the previous patients had hyperammonemia. This is a rare case of severe mitochondrial myopathy in a pediatric patient related to a pathogenic FDX2 variant, suggesting the need for genetic analysis of the FDX2 gene in cases of suspicion of mitochondrial myopathies.
Uninterrupted use of continuous positive airway pressure after endoscopic endonasal approach for pituitary tumors
Authors: North Lauren M. , Rohde Rebecca L. , Cornell Sarah , Long Christopher M. , Zwagerman Nathan T. 
Published: August 2023

Key Points
Resumption of continuous positive airway pressure (CPAP) in the immediate postoperative period after endoscopic endonasal approaches (EEA) for pituitary adenomas can be safe.
Hepatic transcriptome signatures in mice and humans with nonalcoholic fatty liver disease
Authors: Ding Yiming , Dai Xulei , Bao Miaoye , Xing Yuanming , Liu Junhui , Zhao Sihai , Liu Enqi , Yuan Zuyi , Bai Liang 
Published: August 2023

AbstractBackgroundNonalcoholic fatty liver disease (NAFLD) is the main reason for cirrhosis and hepatocellular carcinoma. As a starting point for NAFLD, the treatment of nonalcoholic fatty liver (NAFL) is receiving increasing attention. Mice fed a high‐fat diet (HFD) and hereditary leptin deficiency (ob/ob) mice are important NAFL animal models. However, the comparison of these mouse models with human NAFL is still unclear.MethodsIn this study, HFD‐fed mice and ob/ob mice were used as NAFL animal models. Liver histopathological characteristics were compared, and liver transcriptome from both mouse models was performed using RNA sequencing (RNA‐seq). RNA‐seq data obtained from the livers of NAFL patients was downloaded from the GEO database. Global gene expression profiles in the livers were further analyzed using functional enrichment analysis and the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway.ResultsOur results showed that the biochemical parameters of both mouse models and human NAFL were similar. Compared with HFD‐fed mice, ob/ob mice were more similar in histologic appearance to NAFL patients. The liver transcriptome characteristics partly overlapped in mice and humans. Furthermore, in the NAFL pathway, most genes showed similar trends in mice and humans, thus demonstrating that both types of mice can be used as models for basic research on NAFL, considering the differences.ConclusionOur findings show that HFD‐fed mice and ob/ob mice can mimic human NAFL partly in pathophysiological process. The comparative analysis of liver transcriptome profile in mouse models and human NAFL presented here provides insights into the molecular characteristics across these NAFL models.
Synergistic flame retardancy of solid acid, hindered N‐alkoxy amine, and halogen compound for polypropylene
Authors: Nakashima Erika , Hosokawa Yoshifumi , Ueno Tomonaga 
Published: August 2023

AbstractPolypropylene (PP) is a thermoplastic resin widely used in various industrial applications. However, the flammability of PP is a severe drawback that lowers operational safety. This study demonstrates the development of flame‐retardant PP. The co‐adding with various solid acids and a hindered N‐alkoxy amine (NOR116 – Flamestab® NOR 116 FF) affects the combustion behavior of PP in a vertical flame test. The co‐adding of silica alumina (SA) and NOR116 with PP promoted the melt drip, suppressed upward combustion heat, and shorter the combustion time. The decomposition products of NOR116 induced the cleavage of the main chain of PP, and it quenched the radicals on the surface of the SA particles because SA has abundant acidic sites and large pores, facilitating the adsorption of a substantial quantity of NOR116. The molecular weight of PP was controlled to 103 ~ 104 before the combustion to achieve an increase in the melt flow ability and suppress the upward combustion. Furthermore, a small amount of a halogen‐based flame retardant was incorporated into the PP/SA/NOR116 sample, and the specimens could instantly self‐extinguish on the gas phase by radical trap.
Radiation risks and information needs of pregnant and lactating women
Authors: Mettler Fred A. 
Published: August 2023

AbstractThis a historical review and current information regarding risks and effects of ionizing radiation in the context of human pregnancy and in particular the information needed for pregnant women to understand the type and magnitude of risks placing them in a realistic context. Much of our understanding comes from early animal studies but has been supported by studies of human exposure to medical radiation, radiation accidents and nuclear weapons.
Validation of a modified Chinese‐language version of the Davos Assessment of Cognitive Biases Scale (MCL‐DACOBS) in a sample of Chinese patients with schizophrenia
Authors: Chen Guangdong , Li Ranli , Tian Hongjun , Ma Xiaoyan , Sun Yun , Jia Feng , Ping Jing , Cai Ziyao , Zhu Jingjing , Zhuo Chuanjun , Pan Zhi 
Published: August 2023

AbstractIntroductionThe Davos Assessment of Cognitive Biases Scale (DACOBS) is widely used to assess cognitive biases in patients who have schizophrenia. However, the lack of a modified Chinese‐language version of the DACOBS (MCL‐DACOBS) precludes Chinese schizophrenic patients from treatment aimed at normalizing cognitive biases, impacting their prognosis. Here, we aimed to produce a DACOBS for China and test the validity and reliability of the resultant MCL‐DACOBS.MethodsEighteen researchers collaborated to develop the MCL‐DACOBS: A total of 15 researchers modified and translated the English version of the DACOBS, 1 native‐English‐speaking researcher back‐translated the scale, and 2 Chinese sinologists localized and optimized the language of the MCL‐DACOBS. Forty‐two volunteers checked the scale items’ comprehensibility, and the two sinologists performed further localization and optimization based on their feedback. The final version of the MCL‐DACOBS used in this study was thus derived from the harmonized English‐language version of the scale. Confirmatory factor analyses (CFAs) were used to examine the best latent structure of the MCL‐DACOBS. Cronbach's α and intraclass correlation coefficients (ICCs) were used to check the reliability. The discriminative ability of the MCL‐DACOBS was assessed according to the area under the receiver operating characteristic curve.ResultsThe CFA showed that all items loaded onto factors with loadings >0.400. A two‐factor structure showed a good model fit (root mean square error of approximation = .018, Tucker–Lewis index = .978, comparative fit index = .984). Promax rotation demonstrated that each item had a high factor load (0.432–0.774). Cronbach's α coefficient and ICC for the MCL‐DOCABS were .965 and .957, respectively, indicating that the scale has ideal reliability.ConclusionThe MCL‐DACOBS has good validity and good reliability, and its psychometric properties indicate that it is a valid tool for measuring cognitive biases in Chinese patients with schizophrenia.
Meta‐analysis of PD‐(L)1 inhibitor plus chemotherapy versus chemotherapy as first‐line treatment in extensive‐stage small‐cell lung cancer
Authors: Lu Jiangyue , Lei Xiao , Zhang Pei , Du Lehui , Zhang Zhibo , Qu Baolin 
Published: August 2023

AbstractBackgroundImmunotherapy targeting programmed death 1(PD‐1) and its ligand (PD‐L1) has been successful in extensive‐stage small cell lung cancer (ES‐SCLC). However, first‐line PD‐(L)1 inhibitor combined with chemotherapy (immunochemotherapy) versus chemotherapy has not been well studied.MethodsRandomized controlled trials had been searched from PubMed, Embase, and the Cochrane Library until December 29, 2022. Randomized effect consistency models were applied for estimating the pooled hazard ratios (HRs) and odds ratios (ORs). Study outcomes included overall response rate (ORR), progression‐free survival (PFS), overall survival (OS), 6‐month and 1‐year disease progression rate, 1‐year and 2‐year mortality rate, and Grade ≥3 adverse events (AEs).ResultsSix eligible trials with 2600 ES‐SCLC patients were included. Compared with chemotherapy, immunochemotherapy significantly improved ORR (OR 1.32, 95% CI 1.07–1.63; p = 0.01), PFS (HR 0.68, 95% CI 0.58–0.78; p < 0.001), and OS (HR 0.72, 96% CI 0.66–0.78, p < 0.001) without increasing Grade ≥3 AEs (p = 0.07). Compared with patients with chemotherapy, the 6‐month disease progression rate was reduced by 0.39 (p = 0.01) and the 1‐year disease progression rate was reduced by 0.75 (p < 0.001), the 1‐year mortality rate was reduced by 0.33 (p < 0.001) and the 2‐year mortality rate was reduced by 0.50 (p < 0.001) respectively in patients with immunochemotherapy. However, patients with brain metastases failed to prolong PFS and OS from immunochemotherapy (p > 0.05).ConclusionCompared with chemotherapy, PD‐(L)1 inhibitor plus chemotherapy as first‐line treatment could improve the efficacy and prognosis of ES‐SCLC patients without more serious side effects. However, more research is needed to validate these results.
Behavior of a Dynamic Covalent Library Driven by Combined Pd(II) and Biphasic Effectors for Metal Transport between Phases
Authors: Moneuse Raphaël , Bourgeois Damien , Le Goff Xavier , Lehn Jean‐Marie , Meyer Daniel 
Published: August 2023

AbstractThis work reports the effect of Pd(II) as chemical effector on an acylhydrazone‐based dynamic covalent library (DCL) in biphasic systems (water/chloroform). The constituents of the DCL are self‐built and distributed in the two phases, two of them are lipophilic enough to play the role of a carrier agent that may transfer Pd(II) from the aqueous phase to the organic phase. Upon addition of Pd(II), the DCL of components exhibits a strong amplification of the constituent that is the most adapted to stabilize Pd(II) in chloroform as well as its agonist in water. This evolution is driven by the combination of the interaction of the DCL with Pd(II) and the presence of the two phases. This study paves the way to a novel approach for liquid/liquid extraction and metal recovery by means of adaptive extractant species generated in situ by a DCL.
Measurement of Adsorption Properties at Different Scales: from Zero Length Column Experiments on Single Pellets to Breakthrough Curves
Authors: Kalaitzopoulos Stylianos , Mangano Enzo , Brandani Stefano 
Published: August 2023

AbstractThe ZLC technique is a powerful technique for the measurement of diffusion in nanoporous materials using mg quantities of a sample. Questions remain on whether the measured properties are representative of larger samples. A methodology has been developed to carry out single pellet experiments to determine average properties and variability of equilibrium and kinetic properties. To demonstrate the approach, n‐pentane on HISIV3000 extrudates was used as the test system, which was shown to be macropore diffusion controlled. Results on nine pellets provided average values showing a perfect match to breakthrough column experiments with a sample two orders of magnitudes larger.
Organometallic Allene [(μ‐C)(Fe(CO)4)2]: Bridging Carbon Showing Transformation from Classical Electron‐Sharing Bonding to Double σ‐Donor and Double π‐Acceptor Ligation
Authors: Parvathy Parameswaran , Parameswaran Pattiyil 
Published: August 2023

AbstractAllenes (R2C=C=CR2) have been traditionally perceived to feature localized orthogonal π‐bonds between the carbon centres. We have carried out quantum‐mechanical studies of the organometallic allenes envisioned by the isolobal replacement of the terminal CH2 groups by the d8 Fe(CO)4 fragment. Our studies have identified two organometallic allenes viz. D2d symmetric [(μ‐C)(Fe(CO)4)2] (2) and D3 symmetric [(μ‐C)(Fe(CO)4)2] (3) with trigonal bipyramidal coordination at the Fe atoms. Compound 2 features the bridging carbon atom in an equatorial position with respect to the ligands on the TM centre, while 3 features the central carbon atom in an axial position. The bis‐pseudoallylic anionic delocalisation proposed in the C2‐C1‐C3 spine of organic allene is retained in the organometallic allene 2, and is transformed to a typical three‐centre bis‐allylic anionic delocalisation in the organometallic allene 3. The topological analysis of electron density also indicates a bis‐allylic anionic type delocalisation in the organometallic allenes. The quantitative bonding analysis using the EDA‐NOCV method suggests a transition from classical electron‐sharing bonding between the central carbon atom and the terminal groups in 1 to donor‐acceptor bonding in 3. Meanwhile, both electron‐sharing and donor‐acceptor bonding models are found to be probable heuristic bonding representations in the organometallic allene 2.
Corporate social responsibility and dividend payout policy in extraordinary time: Empirical study of South Africa
Authors: Buertey Samuel , Ramsawak Richard , Dziwornu Raymond K. , Lee Yong‐Seok 
Published: August 2023

AbstractCorporate social responsibility (CSR) is a strategic tool that firms use to gain competitive advantage and enhance profitability in the long run, yet its effect on dividend payout in extraordinary times is limited. Grounded in stakeholder and dual responsibility theories, this study examines the effect of CSR on the relationship between COVID‐19 and dividend payout. Data from the period 2015–2021 were obtained from 114 non‐financial listed firms on the Johannesburg Stock Exchange, South Africa, and analyzed by multivariate and logit regression techniques. COVID‐19 has a negative effect on the amount and likelihood of dividend payment, while CSR performance has a positive effect on the likelihood and amount of dividend payment. However, the result of the negative effect of COVID‐19 on dividend payment does not differ between high and low CSR performing firms. Conversely, the impact of COVID‐19 and CSR on dividend payment differ between high and low financial constraint firms. Shareholders should learn to manage their expectations of dividends payment during times of crisis like COVID‐19, as firms tend to focus more on addressing the needs of stakeholders through CSR initiatives, which will enhance profit in the long term, rather than paying out dividend to shareholders.
An intervention mapping adaptation framework to develop a self‐help intervention for athletes with eating disorder symptoms
Authors: Sandgren Sebastian S. , Haycraft Emma , Arcelus Jon , Plateau Carolyn R. 
Published: August 2023

AbstractObjectiveThis research forum describes the use of the intervention mapping for adaptation (IMA) framework to develop and evaluate a novel intervention for athletes with mild eating disorder (ED) symptoms.MethodsThe six IMA steps were followed. In step 1 (needs assessment), we conducted a systematic review of athlete ED interventions and held interviews/focus groups with athletes and sports professionals to inform intervention format and delivery. In step 2 (intervention search), needs assessment information guided the search for an evidence‐based intervention suitable for adaptation to athletes. In steps 3 and 4 (intervention development), the identified intervention was adapted and feedback sought from athletes and sport professionals. In steps 5 and 6 (implementation and evaluation), a feasibility study was conducted with athletes (n = 35; females: n = 27; Mage = 27.1).ResultsThe review highlighted poor evidence for the acceptability and relative efficacy of existing interventions, which were all delivered face‐to‐face in groups. Interview/focus group data suggested a need for more accessible intervention formats (e.g., self‐help). One non‐athlete self‐help intervention was determined suitable for adaptation to athletes, and adaptations were made. Initial feedback suggested the adapted intervention was relevant within sport settings. The feasibility study revealed that the intervention (MOPED‐A: Motivational and Psycho‐Educational Self‐Help Programme for Athletes with Mild Eating Disorder Symptoms) can be feasibly implemented, is acceptable to athletes and shows potential for reducing ED symptoms.DiscussionIMA is a useful framework for developing participant‐centered and evidence‐based interventions. The findings and approach taken provide a framework for other researchers and clinicians in developing similar interventions in the ED domain.Public SignificanceThe novel self‐help intervention described in this article was developed using intervention mapping and provides promise as a tool for reducing eating disorder symptoms in athletes. We describe how adopting and systematically following a health intervention development approach, such as intervention mapping, can ensure that eating disorder interventions are participant‐centered, contextually relevant, and evidence‐based, which in turn could help to maximize their reach and effectiveness.
Chronic encephalomyelitis virus exhibits cellular tropism and evades pDCs by binding to sialylated integrins as the cell surface receptors
Authors: Takeda Kazuya , Kaifu Tomonori , Michihata Ryunosuke , Kinugawa Naotaka , Fujioka Atushi , Tateno Ayaka , Toshima Kaoru , Kanoh Hirotaka , Inamori Kei‐Ichiro , Kamijo Keiju , Himeda Toshiki , Ohara Yoshiro , Inokuchi Jin‐Ichi , Nakamura Akira 
Published: August 2023

AbstractTheiler's murine encephalomyelitis virus (TMEV) causes a chronic demyelinating disease similar to multiple sclerosis in mice. Although sialic acids have been shown to be essential for TMEV attachment to the host, the surface receptor has not been identified. While type I interferons play a pivotal role in the elimination of the chronic infectious Daniel (DA) strain, the role of plasmacytoid dendritic cells (pDCs) is controversial. We herein found that TMEV binds to conventional DCs but not to pDCs. A glycomics analysis showed that the sialylated N‐glycan fractions were lower in pDCs than in conventional DCs, indicating that pDCs are not susceptible to TMEV infection due to the low levels of sialic acid. TMEV capsid proteins contain an integrin recognition motif, and dot blot assays showed that the integrin proteins bind to TMEV and that the viral binding was reduced in the desialylated αXβ2. αXβ2 protein suppressed TMEV replication in vivo, and TMEV co‐localized with integrin αM at the cell membrane and TLR 3 in the cytoplasm, suggesting that αM serves as the viral attachment and entry. These results show that the chronic encephalomyelitis virus utilizes sialylated integrins as cell surface receptors, leading to cellular tropism to evade pDC activation.
The effect of lacosamide in peripheral neuropathic pain: A randomized, double‐blind, placebo‐controlled, phenotype‐stratified trial
Authors: Carmland Malin Erika , Kreutzfeldt Melissa Dall , Holbech Jakob Vormstrup , Brask‐Thomsen Peter Kolind , Krøigård Thomas , Hansen Peter Nørregaard , Tankisi Hatice , Jensen Troels Staehelin , Bach Flemming Winther , Sindrup Søren Hein , Finnerup Nanna Brix 
Published: August 2023

AbstractBackgroundNeuropathic pain is common and difficult to treat. The sodium channel blocker lacosamide is efficacious in animal models of pain, but its effect on neuropathic pain in humans is inconclusive.MethodsIn a multicentre, randomized, double‐blinded placebo‐controlled phenotype stratified trial, we examined if lacosamide produced better pain relief in patients with the irritable nociceptor phenotype compared to those without. The primary outcome was the change in daily average pain from baseline to last week of 12 weeks of treatment. Secondary and tertiary outcomes included pain relief, patient global impression of change and presence of 30% and 50% pain reduction.ResultsThe study was prematurely closed with 93 patients included and 63 randomized to lacosamide or placebo in a 2:1 ratio, of which 49 fulfilled the per protocol criteria and was used for the primary objective. We did not find a better effect of lacosamide in patients with the irritable nociceptor phenotype, the 95% CI for the primary objective was 0.41 (−1.2 to 2.0). For all patients randomized, lacosamide had no effect on the primary outcome, but significantly more patients were responders to lacosamide than during placebo, with an NNT of 4.0 (95% CI 2.3–16.1) and 5.0 (95% CI 2.8–24.5) for 30% and 50% pain reduction respectively. We did not identify any predictors for response. Lacosamide was generally well tolerated.ConclusionWe could not confirm that lacosamide was more efficacious in patients with the irritable nociceptor type, but the study was prematurely closed, so we cannot exclude a small difference.SignificanceTreatment of neuropathic pain is often a trial and error process. Little is known about which patient benefit from which kind of medication. The sodium channel blocker lacosamide shows variable effect on neuropathic pain. Pain sensory phenotype, as defined by quantitative sensory testing, did not predict response to treatment with lacosamide.
The effect of irrigation management on rice grain yield, irrigation water productivity and methane emissions in northern Iran
Authors: Yousefian Mostafa , Shahnazari Ali , Ahmadi Mirkhalegh Z. , Sarjaz Mahmoud Raeini , Arabzadeh Behrouz 
Published: August 2023

AbstractThis experiment aims to study the effect of water‐saving irrigation on rice production and methane emissions. Three irrigation methods, that is, flooding irrigation, deficit irrigation (DI) and alternate partial root‐zone drying (APRD), were employed in a 2‐year field trial. The experiment was conducted in a randomized complete block design with three replications. For the DI and APRD treatments, plots were not irrigated until the soil matric potential reached −10 (DI10 and APRD10), −30 (DI30 and APRD30) and −60 kPa (DI60 and APRD60). In the APRD treatments, two adjacent furrows of each plant row were alternately irrigated in consecutive irrigation events. The DI and APRD treatments did not affect yield components when the soil matric potential was −10 kPa. Applying APRD treatments increased irrigation water productivity by 45%, 51% and 31% for soil matric potentials of −10, −30 and −60 kPa, respectively. On average, water stress treatments reduced methane emissions by 78% compared to flooding treatment. On average, the APRD treatments decreased the water input by 10% compared with the DI treatments while achieving a 2.5% higher yield. This is the first study to outline the effect of APRD on methane emissions and rice production. These findings suggest that APRD could be a valuable strategy to mitigate methane emissions without risking rice yield reduction.