bluuebunny/crossref_metadata_2025_split huggingface dataset:
Precise Fabrication of Tactile Sensors using a Custom Additive Manufacturing Platform
Authors: Wei Danming , Zhang Ruoshi , Lin Ji-Tzuoh , Ratnayake Dilan , Olowo Olalekan , Nimon Andrew , Alqatamin Moath , Sherehiy Andriy , Popa Dan 
Published: January 2023

Abstract
This paper presents the NeXus, a precision robotic platform with additive manufacturing capabilities that can be used to prototype strain gauge-based tactile sensors – SkinCells - on flexible substrates. An Aerosol Inkjet printer was employed to print the strain gauge structures of the SkinCell sensor. The design of this sensor combines curvilinear geometries representing both a radial shape structure and an arc shape structure, which have opposite gauge responses when the force is applied to the center of the sensor. The fabrication process of the SkinCell sensor is predicated on a parametric kinematic calibration of the NeXus to identify features on the sensor substrate and align them to the printing and metrology tools. Several strain gauge SkinCell sensor samples were printed on pre-fabricated flexible substrates using the NeXus. Results indicate a calibration precision of approximately 36 microns with 100 microns line-width features. This precision is sufficient to ensure that all printed gauges are electrically connected to the prefabricated contacts. Furthermore, the printing errors accumulating during a continuous four-sensor array print also fall within the contact tolerance.
Exploration of biological significance of m6A-related genes in Wilms tumor
Authors: Zhuo Yingquan , Zhang Wengqi , Du Jun , jiang Hua , Sun Xu , Chen Youwang , Nie Meilan , Xu Zhongmin , Gu Huajian 
Published: January 2023

Abstract
Background: Wilms tumor (WT) is an embryonal abdominal malignant tumor which is a common renal malignant tumor in children. N6-methyladenosine (m6A) RNA methylation can dynamically regulate the development of tumors. However, m6A-related genes in WT have not yet been identified and researched.
Methods: In this study, the RNA-seq data of TARGET-WT were extracted from the UCSC Xena for bioinformatics analysis.
Results: 296 candidate hub genes were obtained by intersecting 3 gene sets (8610 gene modules with significantly associated m6A RNA methylation score, 7774 differentially expressed genes (DEGs) between 121 WT patients and 6 control samples, 763 DEGs between high and low score groups of m6A RNA methylation). Survival analysis of the 296 genes yielded 4 hub genes (ADGRG2, CPD, CTHRC1, and LRTM2) associated with WT prognosis. Subsequently, a prediction model with the 4 hub genes was developed and the model had good predictive power for the WT prognosis. In addition, 7 immune gene sets were obtained by intersecting 2 gene sets (18 significant difference immune gene sets between the WT group and control group, 10 immune gene sets related to the hub genes). Among them, APC_co_stimulation, CCR, Macrophages, Parainflammation, Treg, and Type_II_IFN_Reponse were low expressed in the WT, and only Th1_cells were highly expressed in the WT. APC_co_stimulation, CCR, Macrophages, Parainflammation, Treg, and Type_II_IFN_Reponse are negatively correlated with LRTM2, Th1_cells are positively correlated with ADGRG2, CCR is negatively correlated with CPD, CCR is positively correlated with CTHRC1. Finally, qRT-PCR results showed that the expression levels of the 4 hub genes were up-regulated in different WT cell lines compared with 293T cell lines.
Conclusion: In conclusion, ADGRG2, CPD, CTHRC1, and LRTM2 may be m6A-related genes in WT, which have potential prognostic value and play an immunoregulation role in WT.
Cost Effectiveness Comparison of Implementing Intraoperative Margin Assessment using Radiofrequency Spectroscopy or Full Cavity Shave Margins to Reduce Re-excision in Breast Conserving Surgery: A Pro-Forma
Authors: Gilmore Richard C. , Chen Jennifer , Dembinski Robert , Reissis Yannis , Milek David , Cadena Lisa , Habibi Mehran 
Published: January 2023

Abstract
Background:
In an effort to reduce positive margins and subsequent re-excisions after breast conserving surgery (BCS), many providers utilize either a Full Cavity Shave (FCS) approach or intraoperative margin assessment using MarginProbe Radiofrequency Spectroscopy. Although both FCS and MarginProbe have been shown to reduce positive margins by ³50%, little has been reported about their economic impacts. We created a functioning Pro-Forma for use by facilities and payers to evaluate the cost-effectiveness of implementing FCS or MarginProbe.
Methods:
A decision tree demonstrating three possible surgical pathways, BCS, BCS+FCS, and BCS+MarginProbe was developed with clinical inputs for re-excision rate, rate of mastectomy conversion, and rate of breast reconstruction derived from literature review. A pathway cost formula was created using the decision tree and financial inputs derived from the nation’s largest database of private payor and Medicare claims data (fairhealth.org). This data was utilized to create a customizable Pro-Forma for cost-effectiveness analysis.
Results:
In the privately insured population, MarginProbe provides a cost-savings over BCS alone when baseline re-excision rates are over 20% and FCS becomes cost-saving when baseline re-excision rates are over 29%. For Medicare patients, MarginProbe provides a cost-savings when baseline re-excision rates exceed 34%, and FCS becomes cost-saving for re-excision rates over 52%.
Conclusions:
Utilizing either an FCS approach or the MarginProbe system may be cost-effective solutions to reducing breast re-excisions rates depending on surgical volume and baseline re-excision rates. The degree of cost effectiveness of these interventions for healthcare facilities and payers can be evaluated using the Pro-Forma outlined herein.
Environmental Impact of MSW Landfills in Arid Climates - Case Study of Mathuradaspura, Jaipur
Authors: Kulhar Kuldeep Singh , Singh Om Prakash , Meena Charat Lal 
Published: January 2023

Abstract
For disposal of solid waste, the conventionally utilized approach in Jaipur is the landfilling. It is a notable fact that landfill causes pollution of whole environmental elements that can be demonstrated by analysing the figure for climatic, hydrological and geological properties about the state. The emission of gas as well as leachate arising through the sanitary dumping ground in the atmosphere poses a significant threat for the environmental concern and human that comprises groundwater and air pollution. The methane emission causes an effect on environment with prospective health hazards. The organic matter lying in the heaps of waste at the landfill site decomposes being responsible for GHG emissions (Green House Gas emissions) sharing global warming. GHGs are responsible for extreme weather conditions and uncertain climate sequences. This study demonstrates a review of those environmental threats coming from landfilling applications and negative environmental impact. A comprehensive investigation was carried out for landfill site through sampling and testing for assessing the results of release of SW (solid wastes). The investigations revealed the effects of MSW at the landfill site showing presence of heavy metal (Fe, Cd, Pb, and Ni) indicating the pollution level. The present study is an endeavor to evaluate the current framework of SWM (solid waste management) and to propose corrective measures required to diminish the environmental as well as socio-economic effects for enhancing sustainability of SWM system of Jaipur.
Relative Solution Equilibria and Chemical Speciation study of Divalent Manganese and Cobalt Ternary complexes with Azelaic acid dihydrazide (AZDH), L-Proline &amp; L-Lysine
Authors: Devi D. Nirmala , Rani B. Uma , Shyamala P. , Satyanarayana A. 
Published: January 2023

Abstract
A solution equilibria study of ternary systems containing Mn2+ and Co2+ with Azelaic acid dihydrazide (AZDH) as L and α-amino acids L - Proline and L - Lysine as X of type [MmLlX xHh], was carried out with the help of potentiometric method for data acquisition followed by chemometric modelling studies, (where m = 1, 2; The SOPHD programme is used to generate relative simulation and titration curves. The speciation analysis and evaluation of formation constants (303K and 0.01M ionic strength) were computed with the MINIQUAD-75 computer software, and concentration distribution graphs were generated with the HySS programme. Various statistical parameters were considered to choose the best-fit chemical models. The ∆log K formulation was used to compare the stability of ternary compleyxes with binary complexes.
Possible Protective Effects of Uridine on Atrial Fibrillation: A Mendelian Randomization Study
Authors: Xu Xintian , Zhang Xiaoyu , Cheng Shiyao , Ouyang Mao 
Published: January 2023

Abstract
Uridine, a pyrimidine nucleoside, plays a crucial role in the synthesis of metabolites. According to recent research, higher plasma uridine levels are associated with a lower risk of atrial fibrillation (AF). However, the casual inference between uridine and AF is still unknown. In this study, we used the Mendelian randomization (MR) approach to elucidate possible causality. Three genetic variants associated with uridine were identified from the Metabolomics GWAS server (7,824 participants); summary-level datasets associated with AF were acquired from a genome-wide association study (GWAS) meta-analysis containing 1,030,836 European participants (60,620 AF cases). We duplicated the MR analyses using datasets from AF HRC studies and the FinnGen consortium and conducted a meta-analysis to combine the main results. The incidence of AF was incidentally associated with a one standard deviation increase in genetically determined plasma uridine [odds ratio (OR), 0.27; 95% confidence interval (CI), 0.16, 0.47; p = 2.39 ⋅ 10− 6)]. In the meta-analysis that combined the various datasets, the association remained consistent (OR, 0.27; 95% CI, 0.17, 0.42; p = 1.34 ⋅ 10− 8). In conclusion, genetic liability for higher plasma uridine levels is associated with a reduction in the risk of AF. Raising plasma uridine levels might provide new opportunities for AF prophylaxis.
Agreement between CO2 gap determined from peripheral blood and mixed venous blood in septic shock patients
Authors: Orso Daniele , Molinari Chiara , Bacchetti Giacomo , Zanini Victor , Montanar Valentina , Copetti Roberto , Guglielmo Nicola , Bove Tiziana 
Published: January 2023

Abstract
Purpose: The veno-arterial CO2 difference (Pv-aCO2) is a useful marker capable of identifying a subpopulation of shocked patients who present a cardiac output insufficient for the tissue metabolic demands. Some Authors have highlighted a linear relationship between Pv-aCO2 determined by mixed or central venous blood. This research aims to establish whether there is a linear relationship between Pv-aCO2 determined by peripheral venous blood (Pv-aCO2p) and mixed venous blood and the agreement between the two measures.
Methods: Prospective, single-centre, observational clinical study on septic shocked and invasively ventilated patients during the first 24 hours from admission in ICU.
Results: On 38 determinations, the Bravais-Pearson r between Pv-aCO2 and Pv-aCO2p was 0.70 (95%CI 0.48 – 0.83; p-value = 1.25 x 10^-6). The Bland-Altman test's mean bias was 4.11 mmHg (95%CI 2.82 – 5.39); the repeatability coefficient was 11.05. The differential and proportional bias were 2.81 (95%CI 0.52 – 5.11) and 1.29 (95%CI 0.86 – 1.72), respectively, through the Taffé method.
Conclusion: Pv-aCO2p could be used in clinical settings wider than the ICU alone, where central venous access is not routine, to establish early the adequacy of the circulation and, more specifically, of cardiac output versus tissue metabolic demands in septic patients.
WITHDRAWN: Influence of a structured microbiological endotracheal monitoring on the outcome of critically ill COVID-19 patients: an observational study
Authors: Dibos Miriam , Haschka Stefanie Julia , Abbassi Rami , Schneider Jochen , Schmid Roland M. , Rasch Sebastian , Lahmer Tobias 
Published: January 2023

Abstract
Purpose
In past influenza pandemics and the current COVID-19 pandemic, bacterial endotracheal superinfections are a well-known risk factor for higher morbidity and mortality. The goal of this study was to investigate the influence of a structured, objective, microbiological monitoring on the prognosis of COVID-19 patients with mechanical ventilation.
Methods
A structured microbiological monitoring (at intubation, then every 3 days) included collection of endotracheal material. Data analysis focused on the spectrum of bacterial pathogens, mortality, as well as ICU-, hospital-, and mechanical ventilation duration.
Results
29% of the patients showed bacterial coinfection at the time of intubation or within 48h, 56% developed ventilator-associated pneumonia (VAP). Even though patients with VAP had significantly longer ICU-, hospital and mechanical ventilation duration, there was no significant difference in mortality between patients with ventilator-associated pneumonia and patients without bacterial infection.
Conclusion
Bacterial coinfections and ventilator-associated pneumonia are common complications in influenza and COVID-19 patients. In contrast to already published studies, in our study implementing a structured microbiological monitoring, COVID-19 patients with ventilator-associated pneumonia did not show higher mortality. Thus, a standardized, objective, microbiological screening can help detect coinfections and ventilator-associated infections, refining the anti-infective therapy and influencing the patient outcome positively.
Can Low-High-Density Lipoprotein Be a New Ri̇sk Factor for Multisystemic Inflammatory Syndrome in Children?
Authors: Bostancı Muharrem , Cagan Eren 
Published: January 2023

Abstract
Objectives: Increasing acute phase reactants due to inflammation or infection cause some changes in lipid and lipoprotein metabolism. High-density lipoprotein(HDL) is part of the innate immune system that fights pathogens entering the body. Therefore, we think HDL has prognostic value in multisystemic inflammatory syndrome associated with Coronavirus (MIS-C) as in Kawasaki disease and other diseases.
Study Design: We followed the 51 patients diagnosed with MİSS-C. We divided the patient into two groups according to cardiac involvement, and we compared the laboratory values of the patients.
Results: Of these 51 patients, 65% (33) were male, and 35% (18) were female. We performed the echocardiographic examination on all patients, 69% (35) of the patients had cardiac pathology, and 31%(16) patients had no cardiac involvement. When comparing the patients' cholesterol levels according to cardiac involvement, the triglyceride value was higher in patients with the cardiac involvement group. The median triglyceride values of patients with cardiac participation were 192.6 mg/dl, and those without cardiac involvement were 134.2 mg/dl. (p=0.028) (IQR 119.4 – 122.9). And also, the HDL value was lower in patients with cardiac involvement. We found that the median HDL values of the patients with cardiac participation were 13.65mg/dl, and the median HDL values of the patients without cardiac involvement were 21.8mg/dl(p=0.003)(IQR 6 - 31)
Conclusion: We found that not only high leukocyte and CRP values were associated with the severity of the disease, but also low HDL and high triglyceride values were associated with cardiac involvement.
Occurrence and risk evaluation of endocrine disrupting chemicals in wastewater and surface water of Lahore, Pakistan
Authors: Ashfaq Muhammad , Li Yan , Zubair Muhammad , Rehman Muhammad Saif Ur , Sumrra Sajjad Hussain , Nazar Muhammad Faizan , Mustafa Ghulam , Fazal Muhammad Tahir , Ashraf Humayun , Sun Qian 
Published: January 2023

Abstract
The current study highlights the occurrence, spatial distribution and risk assessment of sixteen endocrine disrupting chemicals (EDCs) including their transformation products (TPs) in the wastewater and surface water of Lahore, Pakistan. The parent EDCs include bisphenol A (BPA), triclosan (TCS), triclocarban (TCC), estrone (E1), estradiol (E2), estriol (E3), ethinylestradiol (EE2), 4-n-octylphenol (4n-OP ), and 4-n-nonylphenol (4n-NP). The TPs include two TPs each of BPA, TCC and estrogens along with a TP of TCS. Most EDCs showed 100% detection frequency in the wastewater with highest median concentration of 1310 ng/L for E3. In the surface water, the highest median concentration was however observed for BPA (54.6 ng/L). Spatial variations in terms of sum of concentration due to all EDCs and their TPs were observed at different sampling points which suggests contamination due to industrial sources. Risk evaluation in terms of risk quotient (RQ) and estradiol equivalent factor (EEQ) showed that most of EDCs and their TPs could pose high risk and estrogenicity to the surrounding environment. From the results of the current study, it is observed that the environment of Pakistan is deteriorating and is potential risk for endocrine disruption. It is therefore recommended to take stringent measures to make it sustainable for current as well as for future generations.
Phytoremediation capabilities of eight wild plants in absorption of three heavy metals (Al, Pb and Zn) in Meyghan Wetland
Authors: Faraji Raziyeh , abdi nourollah , Varvani Javad , ahmadi abbas , Toranjzar Hamid 
Published: January 2023

Abstract
Phytoremediation plant is one of the proposed methods that by accumulating heavy metals in the aerial parts of plants, it is possible to remove these elements from contaminated soils. The aim of this study was to investigate the situation of removal of three heavy metals, Al, Pb and Zn in the soil based on 8 plant species in Meyghan wetland in Markazi province, Iran. One-way analysis of variance (ANOVA) was used to investigate the difference between of heavy elements in the aerial parts, roots of plant species and soil. The results showed that there were significant difference in the contaminants of Al, Pb and Zn in the aerial, root organs of plant and soil. The results of the study of Al changes in the soil and the studied species showed that the amount of this element in the soil is very high and the studied plants do not have the high adsorption capacity of this element. The results of a study of the amount of Pb in aerial parts and roots of plant species showed that the amount of this metal in aerial parts is higher than the root and Halocenemum Strobilaceum has the highest rate of Pb contaminants (0.82 mg/cm3) among the studied species. The results of Zn change in aerial and root limbs showed that the amount of Zn metal contaminants in aerial organs was higher than the root, and Scirpus lacustris (2.14 mg/cm3) had the highest total absorption rate among the species studied.
Quality of raw material and yield of exported sawn wood in the rational use of tropical timber from the Amazon
Authors: STRAGLIOTTO Michelly Casagrande , PEREIRA Bárbara Luísa Corradi , OLIVEIRA Aylson Costa , LENGOWSKI Elaine Cristina , ARRUDA Tatiana Paula Marques , SILVA José Reinaldo Moreira 
Published: January 2023

Abstract
The low sawn timber yield of tropical species is caused by quality of the logs, among other factors. The objective was to evaluate the quality of logs and the sawn wood yield for export of the tropical species Dinizia excelsa Ducke, Hymenolobium heterocarpum Ducke, Dipteryx odorata (Aubl.) Willd., Astronium lecointei Ducke and Qualea paraensis Ducke. The log quality parameters analyzed were conicity, flattening, curving, buttresses, cracks, heartwood percentage and net volume. After sawing, the sawn wood yield was determined. The values of conicity (0.92 cm.m− 1) and flattening (96%) did not differ between species. Qualea paraensis and Hymenolobium heterocarpum showed a better classification for curving. Astronium lecointei showed no buttresses. Qualea paraensis showed better classification for annular ring cracks and Dipteryx odorata for surface and diametrical cracks. Dipteryx odorata (86.75%) and Hymenolobium heterocarpum (82.4%) showed better results for heartwood percentage. Dinizia excelsa (90.1%), Dipteryx odorata (83.6%) and Hymenolobium heterocarpum (82.6%) logs showed higher net volume values. The yield of sawn timber for export differed between species and ranged from 23.9–40.2% for Dinizia excelsa and Qualea paraensis, respectively. There was variation in the quality of the logs and the yield of sawn timber for export due to the distinctive characteristics of the species evaluated.
Green environmental static pressed pile penetration mechanism based on FBG-MEMS joint test technology
Authors: Li Jie , Wang Xin , Wang Yonghong , Wang Zhen , Wang Kai , Jiang Yishun 
Published: January 2023

Abstract
Green environmental static pressure pile technology has always been one of the problems that many scholars urgently need to study. For the stress test of pile-soil interface, this experiment designed the FBG-MEMS joint test technology between the pile-soil interface during the penetration of static pressure piles in cohesive soil. In this test, a model pile is set up in the model bucket. By studying what effects will happen to the pile-soil interface when the pile is in different positions in the bucket, and studying how the boundary effect affects the changes of the indoor test results, the loading device and monitoring system are used to test the pile pressing force, pile shaft axial force and pile-soil interface stress generated during the penetration of the model pile in the model box. The preliminary test verifies the characteristics of simple operation and high accuracy of the test, and also draws the conclusion that with the increase of the penetration depth, the axial force of the pile shaft and the effective lateral pressure of the pile-soil interface increase, but the lateral pressure at the same depth gradually decreases. In addition, the influence of boundary effect is further analyzed. Finally, it is concluded that the boundary effect will increase the pile driving force, pile shaft axial force and effective side friction. The research results have important reference significance for green environmental protection static pressure pile technology in practical engineering.
Association between alcohol consumption and kidney stones in American adults：2007-2016 NHANES
Authors: Zhou Zhen , Huang Zhicong , Ai Guoyao , Guo Xin , Zeng Guohua , Zhu Wei 
Published: January 2023

Abstract
Purpose
To investigate the association between alcohol consumption and kidney stones in American adults.
Materials and Methods
National Health and Nutrition Examination Survey (NHANES) datasets from 2007 to 2016 were utilized. Participants with a history of kidney stones and alcohol consumption aged 20 or older were included. Weighted proportions and regression analysis were used to assess the association between alcohol consumption and kidney stones by adjusting age, gender, race, marital status, education, recreational activities, smoking, and several comorbidities.
Results
Ten samples related to alcohol consumption were included based on questions from the Alcohol Use Questionnaire (ALQ). In the fully adjusted regression model, none of these ten samples demonstrated a significant association with urolithiasis, that is, alcohol consumption was not significantly associated with the incidence of kidney stones.
Conclusions
Alcohol consumption is not significantly associated with the prevalence of kidney stones. This finding requires a more adequate sample size and a more detailed review of the history of kidney stones to be further verified.