bluuebunny/crossref_metadata_2025_split huggingface dataset:
Oxidative Stress and Dopaminergic Metabolism: A Major PD Pathogenic
Mechanism and Basis of Potential Antioxidant Therapies
Authors: Rasool Aamir , Manzoor Robina , Kaleem Ullah  , Afzal Ramsha , Ul-Haq Asad , Imran Hadia , Kaleem Imdad , Akhtar Tanveer , Farrukh Anum , Hameed Sahir , Bashir Shahid 
Published: June 2023

Abstract:
Reactive oxygen species (ROS)-induced oxidative stress triggers the vicious cycle leading
to the degeneration of dopaminergic neurons in the nigra pars compacta. ROS produced during the
metabolism of dopamine is immediately neutralized by the endogenous antioxidant defense system
(EADS) under physiological conditions. Aging decreases the vigilance of EADS and makes the dopaminergic
neurons more vulnerable to oxidative stress. As a result, ROS left over by EADS oxidize the
dopamine-derived catechols and produces a number of reactive dopamine quinones, which are precursors
to endogenous neurotoxins. In addition, ROS causes lipid peroxidation, uncoupling of the electron
transport chain, and DNA damage, which lead to mitochondrial dysfunction, lysosomal dysfunction,
and synaptic dysfunction. The mutations in genes such as DNAJC6, SYNJ1, SH3GL2, LRRK2,
PRKN, and VPS35 caused by ROS have been associated with synaptic dysfunction and the pathogenesis
of Parkinson’s disease (PD). The available drugs that are used against PD can only delay the progression
of the disease, but they produce various side effects. Through their antioxidant activity, flavonoids
can substantiate the EADS of dopaminergic neurons and disrupt the vicious cycle incepted by
oxidative stress. In this review, we show how the oxidative metabolism of dopamine generates ROS
and dopamine-quinones, which then exert unrestrained OS, causing mutations in several genes involved
in the proper functioning of mitochondrion, synapse, and lysosome. Besides, we also present
some examples of approved drugs used for the treatment of PD, therapies in the clinical trial phase,
and an update on the flavonoids that have been tested to boost the EADS of dopaminergic neurons.
5‑ Sulphosalicylic Acid: An Expeditious Organocatalyst for One‑pot
Synthesis of Indenopyrazolones and its Derivatives
Authors: Kushwaha Smriti , Singh Swastika , Baranwal Jyoti , Jyoti Archana 
Published: June 2023

Abstract:
An efficient, 5‑Sulphosalicylic acid (5-SSA) catalysed green protocol for the synthesis of
Indenopyrazolones and its derivatives is reported under metal-free conditions in an ethyl lactate
system. The main advantages of this procedure include the use of an organocatalyst, ethyl lactate as
a recyclable promoting media, practical simplicity, high yields, shorter reaction times, atom economy,
and ease of isolation of the product. These results showed that aromatic aldehydes with electron-
withdrawing groups reacted faster than aldehydes with electron-releasing groups as expected.
According to these observations, aromatic aldehydes with electron-withdrawing groups reacted
more quickly than aldehydes with electron-releasing groups.
Kollaboratív robotok összehasonlító elemzése
Authors: Buri Zsolt 
Published: June 2023

Az alábbi tanulmány négy, az iparban elterjedt robotkar összehasonlítását mutatja be olyan szempontból, hogy az egyetemi oktatásba melyik modell adaptálható a legmegfelelőbben. Az összehasonlító esettanulmány a következő gyártók robotkarjait veszi figyelembe: ABB, Kuka, Universal Robots, Techman Robot. Az összehasonlítás kritériumait a fontossági tényező és a tapasztalatok alapján határoztuk meg. Ezután a kritériumokat az Analitycal Hierarchy Process (AHP) módszer segítségével rangsoroltuk. A négy alternatíva közötti sorrendet a Kesselring módszer segítségével állítottuk fel. A vizsgálat egy kiválasztási módszert mutat be az ipari robotok területén az egyetemi oktatás szemszögéből.
Evaluación de la actividad antimicrobiana de Bacillus australimaris y Pseudoalteromonas sp. asociadas al octocoral Leptogorgia alba
Authors: Avila-Castro Elizabeth , Vargas-Ponce Ofelia , Díaz-Pérez Leopoldo , Rodríguez-Zaragoza Fabián Alejandro , Hernández-Zulueta Joicye , Aguila-Ramírez Ruth Noemí 
Published: June 2023

Los ensamblajes bacterianos asociados a los octocorales les aportan estrategias defensivas mediante la producción de compuestos antimicrobianos para protección frente a los microorganismos patógenos al evitar la colonización por otros microorganismos. Debido a la disminución en el descubrimiento de nuevos compuestos en los entornos terrestres, el potencial de las cepas bacterianas marinas representa una fuente de novedosos compuestos bioactivos. Nuestro objetivo fue evaluar la actividad antimicrobiana de las cepas bacterianas de Bacillus australimaris y las de Pseudoalteromonas sp. aisladas del octocoral Leptogorgia alba de las zonas someras y de las mesofóticas, para conocer el grado de capacidad que tienen para inhibir el crecimiento de los patógenos humanos y de los acuícolas por lo que se realizaron los ensayos cross-streak, difusión en agar por gota, difusión en pozo, difusión en disco, crecimiento sobre celulosa y microplaca de poliestireno. El antagonismo de B. australimaris fue evidente hacia los patógenos de Escherichia coli, Listonella anguillarum, Listeria monocytogenes, Pseudomonas aeruginosa, Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus iniae, y Vibrio campbellii. Por su parte, Pseudoalteromonas sp. impidió el desarrollo de los patógenos E. coli, L. anguillarum, L. monocytogenes, S. iniae, y V. campbellii. Los resultados de este trabajo muestran que las bacterias asociadas a organismos gorgónidos son un recurso biotecnológico potencial en la actividad antimicrobiana.
Perkembangan Teknologi Komunikasi dan Informasi Akar Revolusi di Sekolah Dasar
Authors: Kamelia Kamelia , Reskiana Reskiana , Rahmi Rahmi , Lubis Adiyanata 
Published: June 2023

Informasi di SD merupakan unsur pokok yang secara implisit melekat dalam konsep pembangunan yang terencara. Meskipun peranan informasi di dalam beberapa dekade kurang mendapat perhatian, namun sesungguhnya kebutuhan akan informasi di SD merupakan hal yang tidak kalah pentingnya dari kebutuhan sandang dan pangan bagi siswa sekoal dasar. Kegiatan pembangunan manapun hanya dapat berlangsung dan bisa mencapai sasaran bila dalam setiap tahapnya atau perencanaan, pelaksanaan, dan pengawasan - didasarkan pada informasi yang memadai. Informasi memang diperoleh melalui kegiatan komunikasi tetapi yang sesungguhnya menentukan nilai komunikasi siswa sekolah dasar adalah informasi yang di bawa oleh seorang guru. Revolusi informasi, biasanya difahami sebagai perubahan yang di hasilkan oleh teknologi komunikasi Siswa SD paling penting adalah teknologi untuk menyalurkan informasi dan sistem komputer modern untuk memprosesnya. Dikatakan revolusi karena karena dapat memberikan perubahan yang sangat cepat dalam perkebangan siswa Dasar. Hal yang mendasar dari teknologi komunikasi dan informasi adalah standar. Sementara itu, perkembangan jaringan sangat membutuhkan sebuah standar sistem operasional. Ketika seorang guru menggunakan jaringan untuk berkomunikasi dengan siswanya, maka sesungguhnya secara tidak langsung membutuhkan sistem yang kompatibel antara guru dengan siswanya tersebut. Teknologi memang dapat memberi berbagai dampak positif dan negatif, tetapi dengan pemahaman yang terkait problematika dan dinamakan teknologi yang berkembang, maka setiap individu siswa sekolah dasar yang ada di sebuah Negara menjadi Penguasa teknologi dan bukan sebaliknya menjadi siswa SD yang dikuasai dan dikendalikan oleh teknologi.
Implementasi Supervisi Pendidikan Disekolah SMP Negeri 2 Binjai
Authors: Inom Nasution  , Isma Hayati  , Aldi Bayu Anggara  , Chairunnisa Sagala  , Dwi Hartina  , Nadya Putri Mtd  , Tegar Jaya Putra  
Published: June 2023

Supervisi pendidikan didefinisikan sebagai proses pemberian layanan bantuan profesional kepada guru untuk meningkatkan kemampuannya dalam melaksanakan tugas-tugas pengelolaan proses pembelajaran secara efektif dan efisien. Supervisi juga diartikan sebagai pandangan dari orang yang lebih ahi kepada orang yang memiliki keahlian di bawahnya. Istilah supervise adalah seorang yang professional ketika menjalankan tugasnya. Tujuan pengawasan pendidikan adalah menilai dan memperbaiki faktor-faktor yang mempengaruhi proses pembelajaran dan meningkatkan mutu pembelajaran sehingga menciptakan lulusan yang baik dalam kualitas dan kuantitas. Tujuan dari supervisi pendidikan adalah usaha untuk meningkatkan kualitas pembelajaran dengan cara memberikan layanan dan bantuan untuk meningkatkan kualitas mengajar guru di kelas sehingga membantu guru mengembangkan profesi, pribadi dan membantu kepala sekolah menyesuaikan program pendidikan yang sesuai dengan kondisi masyarakat. Implementasi yang terjadi dilapangan supervisi ini masih sering menemui kendala pengadaan calon supervisor yang kurang dirasa tepat, kreativitas dari seorang supervisor yang masih dikatakan rendah, serta fasilitas yang menjadi pendukung pembelajaran yang tidak merata.
Evaluasi Program Praktek Kerja Lapangan SMK Negeri 2 Padangsidimpuan
Authors: Juri Arfin , Alexsandra Alexsandra , Purwanto Wawan , Indrawan Eko 
Published: June 2023

Penelitian ini bertujuan untuk mengevaluasi pelaksananaan Program PKL SMK Negeri 2 Padangsidimpuan. Evaluasi PKL tersebut dilihat dari aspek context, input, process,product yang dihadapi dalam pelaksanaan program PKL. Metode penelitian yang digunakan yaitu metode kombinasi desain equental Explanatory, menggabungkan metode penelitian kuantitatif dengan menggunakan angket/kuesioner dan kualitatif dengan wawancara secara berurutan, dimana teknik analisis data menggunakan persentase tingkat capaian responden (uji TCR) untuk data kuantitatif dan untuk data kualitatif menggunakan teknik analisis data Miles dan Huberman yaitu: data reduction, data display dan conclusion/verification. Hasil Penelitian menunjukkan bahwa pelaksanaan di SMK Negeri 2 Padangsidimpuan secara keseluruhan meliputi: Evaluasi context memperoleh standar skor rata-rata 83,00% baik. Evaluasi input memperoleh standar skor rata-rata 78,96% cukup. Evaluasi Process memperoleh standar skor rata-rata 68,94% cukup. Evaluasi product memperoleh standar skor rata-rata 77,89% cukup. Berdasarkan temuan penelitian ini disimpulkan bahwa program PKL SMK Negeri 2 Padangsidimpuan adalah 79,09% masih dalam kategori cukup, dan perlu diperbaiki dari berbagai aspek sehingga bisa tercapainya tujuan dari PKL sebagai praktek kerja industry tercapai.
A remnant kidney surgery model in cats induces acute and chronic outcomes that mimic spontaneous chronic kidney disease
Authors: Schmiedt Chad W. , Beita Keren G. , Lourenço Bianca N. , Erickson Maëva C.M. , Herrera Courtney T. , Rissi Daniel R. , Brown Cathy A. , Brown Scott A. 
Published: June 2023

Abstract

OBJECTIVE
To report acute and chronic outcomes of cats with chronic kidney disease (CKD) induced by a remnant kidney model.

ANIMALS
32 purpose-bred cats (n = 15 female, n = 17 male).

PROCEDURES
Cats underwent a 2-stage reduction in renal mass through partial arterial ligation of 1 kidney (day 28) and delayed contralateral nephrectomy (day 0), targeting an 11/12th functional nephrectomy. Acute (days 28 to 29) survival and renal function parameters were compared over time, and the latter were evaluated as predictors for acute mortality. Chronic (days 30 to >1,100) survival, renal function, and morphology were described.

RESULTS
Acutely, renal function deteriorated in all cats (mean ± SD baseline and day 28 serum creatinine mean concentration, 1.13 ± 0.23 mg/dL and 3.03 ± 1.20 mg/dL, respectively; P < .001; and GFR, 3.22 mL/min/kg ± 0.12 and 1.21 mL/min/kg ± 0.08, respectively; P < .001). Seven (22%) cats were euthanized because of clinical signs of uremia after partial nephrectomy. Prenephrectomy renal function tests were not significant indicators for survival during this acute phase. Twenty-five cats entered the chronic phase. Ten cats were euthanized at a median of 163 days from nephrectomy because of progressive renal dysfunction. Median survival times were significantly different when stratified by acute kidney injury grade at day 29. Cats in the chronic phase had clinical courses similar to cats with naturally occurring CKD, and most (13/15) were in CKD stage 2.

CLINICAL RELEVANCE
The remnant kidney model is effective at reducing kidney function to an extent that mimics important characteristics of spontaneous CKD in cats.
SCLang: Graphical Domain-Specific Modeling Language for Stream Cipher
Authors: Qassir Samar Amil , Gaata Methaq Talib , Sadiq Ahmed T. 
Published: June 2023

Abstract
A Stream Cipher (SC) is a symmetric-key encryption type that scrambles each piece of data in clear text to conceal it from hackers. Despite its advantages, it has a substantial challenge. Correct handwriting of the script code for the cipher scheme is a challenge for programmers. In this paper, we propose a graphical Domain-Specific Modeling Language (DSML) to make it easier for non-technical users and domain specialists to implement an SC domain. The proposed language, SCLang, offers great expressiveness and flexibility. Six different methods of keystream generation are provided to obtain a random sequence. In addition, fifteen tests in the NIST suite are provided for random statistical analysis. The concepts of the SC domain and their relationships are presented in a meta-model. The evaluation of SCLang is based on qualitative analysis and is presented to demonstrate its effectiveness and efficiency.
Novel Approaches for Searching and Recommending Learning Resources
Authors: Dien Tran Thanh , Thanh-Hai Nguyen , Thai-Nghe Nguyen 
Published: June 2023

Abstract
This study proposes models for searching and recommending learning resources to meet the needs of learners, helping to achieve better student performance results. The study suggests a general architecture for searching and recommending learning resources. It specifically proposes (1) the model of learning resource classification based on deep learning techniques such as MLP; (2) the approach for searching learning resources based on document similarity; (3) the model to predict learning performance using deep learning techniques including learning performance prediction model on all student data using CNN, another model on ability group using MLP, and the other model on per student using LSTM; (4) the learning resource recommendation model using deep matrix factorization. Experimental results show that the proposed models are feasible for the classification, search, ranking prediction, and recommendation of learning resources in higher education institutions.
Impacts of different planting times on fruit quality and some bioactive contents of different strawberry cultivars
Authors: Unal Nafiye , Okatan Volkan , Bilgin Jale , Kahramanoğlu Ibrahim , Hajizadeh Hanifeh Seyed 
Published: June 2023

ABSTRACT
Strawberry fruit quality traits can be affected by genotype-environment interactions, which determine the consumer acceptance of fruits. This factorial experiment was based on completely randomised blocks (RCBD) with two planting dates (5 and 20 April) and cultivars (‘Albion’, ‘San Andreas’ and ‘Portola’) of strawberry with three replications, and some of pomological and qualitative factors of berry were investigated at harvest. The results showed no significant difference on fruit width, length, weight and firmness, while the plant yield and stem diameter (SD) were affected by different cultivars and planting dates. The minimum SD (19.80) was recorded in cv. ‘Portola’ in the planting date of 20 April. Although the lowest fruit yield was achieved in cv. ‘Portola’ at both planting dates, it had the highest titratable acidity (TA) (0.83%) at the first planting date (5 April). The amount of soluble solid concentration (SSC), electrolyte conductivity (EC), pH, TA and chlorophyll were not affected by cultivar and planting dates. The effect of planting dates and cultivar had no significant effect on berry colour. The highest total phenolic (275.44 mg GAE · 100 mL-1 FW) was recorded in cv. ‘San Andreas’ on the planting date of 20 April, while the lowest value (251.22 mg GAE · 100 mL-1 FW) was recorded in cv. ‘Portola’ on the planting date of 5 April. In general, it is suggested that the least fruit yield in strawberry cv. ‘Portola’ can be correlated with the least SD of the cultivar.
Application and Efficiency of Micro Sprinkler Irrigation
Authors: Jobbágy Ján , Bulla Matúš , Bullová Tatiana 
Published: June 2023

Abstract
In the presented paper, we evaluated the quality of work and the economics of use of irrigation system consisting of micro-sprinklers. The experiment took place on the football field in countryside of southwest Slovakia. The original irrigation system was replaced with a modern one, using a control unit, rainfall sensor, in-ground distribution pipes and micro-sprinklers. The irrigation system consisted of components forming the main and detailed irrigation equipment for irrigating an area of 4,272 m2. The water source was a drilled well with a depth of 80 m. Detailed irrigation equipment consisted of sector micro sprinklers of two types. We monitored 13 rotary micro-sprinklers on the given playground in total. During the measurements, we proceeded according to the international standard ISO 7749-2, while the rain measuring containers were distributed into eight beams. The value of the quality of the work of individual sprinklers, expressed by the coefficient of uniformity of spraying, reached a maximum of 78.18%, but with total coverage it was higher than 90%. Anova statistical analysis did not show a significant dependence of the quality of work on the type of micro-sprinkler (for micro-sprinklers A1, A2 A3: F = 2.95, P >0.05; for micro-sprinklers B, C: F = 0.35, P >0.05). From the viewpoint of evaluating the economic return, the investment proved to return within the period of 4.2 years.
Bioeconomy Adaptation to Climate Change: A Case Study of Food Waste in Slovakia
Authors: Lazorčáková Ema , Rajčániová Miroslava 
Published: June 2023

Abstract
Climate change, periods of droughts or, conversely, increased rainfall significantly affect agronomic patterns and biomass production. In addition, if agriculture and food industry compete with other industries for land and biomass, the priority is given to agro-food use and ensuring food security. This is the main reason why food waste is a promising alternative source of biomass for the industrial segment of the bioeconomy. Moreover, the reuse of food waste leads to circular and sustainable value chains. The aim of this paper is to explore the situation of food waste utilization in Slovakia. We assess the current level of food waste produced by households and its potential as a biomass source. However, to convert food waste into a valid industrial input, it has to be collected separately. The study shows the practice of food waste collection in two Slovak cities, where food waste is used to produce soil substrate and bioelectricity, respectively.
Geopolitical Advantages of Arab Countries and their Impact on the Stability of the Arab Region 2001
Authors: Sabah Nueas Shanafah  
Published: June 2023

The geopolitics means the linkage of geographical elements to the act and activities of policy-making and foreign policy of a state, and the geopolitics theories associated also with the politics of power and influence.
The Arab countries possess a unique site in the map of the world since it linked three continents ( Asia, Africa and Europe ) ,it also overseeing universal straits(Gibralter, Aden ,Bab el Mandeb ,Hormuz and Suez Canal ) through which 70% of the world trade is passing , besides the wealth of fertile soil and mineral and diligent population.
The Arabs states s geopolitics needs to activate and monopolize to achieve prosperity and power.
The leaders and policy –makers of Arab states have to reread their geography and determine the vital points of their geopolitical position.
The challenges of rail linkage between Iraq and Kuwait and the opportunities for national alternatives (the port of Faw، the dry canal، and the link with the Belt and Road project as a model)"
Authors: SAAD OBAID ALWAN AL SAEEDI  
Published: June 2023

Decision-makers in each country work to define a list of internal and external interests، goals and threats to their countries according to the nature of their awareness of these interests، goals and threats.
Hence، Iraq is not an exception to this rule، and the process of evaluating its interests and the objectives of its foreign policy is subject to the pattern of awareness of decision-makers and the influencing forces in defining its basic interests، which often witness some kind of difference in defining them، evaluating their importance and determining the size of the threats they face. And among these interests and threats that have witnessed a difference in the assessment of their importance or danger is the railway connection with Kuwait or other countries، including Iran،
At a time when some political forces and some personalities see the importance of the railway connection to Iraq، others، and with them the majority of the Iraqi people، see the danger of this connection to the interests of Iraq. In particular، its negative impact on the completion of the construction of the Grand Port of Faw and the dry canal، which are considered major national projects on which they are relied upon in creating a major development leap that mitigates the impact of the rentier impact of the economy and contributes to diversifying the national economy Especially when it is successful in linking with international trade projects، including the Chinese Belt and Road project، which will give Iraq an important economic-strategic advantage.
" The origins of the neo-conservative political thought between Straussie and Trotskyism and its implications for the Arab region"
Authors: Husam  kassyai Hussein  
Published: June 2023

The origins of the political thought of the neo-conservative movement stem from non-American European references, and non-Christian Jewish theological beliefs, especially the ideas of Leo Strauss, the German Jewish thinker, and Leo Trotsky, the Russian Jewish thinker who formulated the idea of ​​the neo-conservative movement with this conclusion that drew its horizons to the world, especially the Middle East from In order to achieve the greatness of the American Empire, its hegemony and its sovereignty over the whole world, and because the theological references of the movement are of Jewish fundamentalism (Strauss and Trotsky), this opened the door of ideological affiliation to the movement in front of the Jews of America and Europe. And then, in a geopolitical way, it affected the Middle East, where securing the existence of (the Zionist entity) / “the State of Israel” required that intervention in the affairs of the countries of the Arab region as neighbors of the Zionist entity, and demanded a just solution to the Palestinian issue, and this influence is one of the most prominent pillars and foundations of the political thought of the neo-conservative movement In the USA and the world.
It seems that the influence of the revolutionary Trotskyite philosophy is more evident in neo-conservative thought than the influence of Straussian philosophy, although this reference was not explicitly declared in the literature of American political thought or political thought critical of neo-conservative thought, which is what we perceive in this study as new, especially if We looked at the origins of the Zionist movement in its infancy with "Leo Pinsker", "Theodor Herzl", "Vladimir-Raif Jabotinsky" who write down the most socialist whose heirs from the Zionists benefited from the exploitation and employment of Trotsky's socialist ideas to a greater extent than Strauss, and they presented the socialist system over the liberal in formulating the idea Zionism