bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bringing Bonhoeffer into Dialogue with Schmitt in Contemporary China
Authors: Lam Jason 
Published: May 2023

Abstract
Since the 2000s there has been a group of prominent scholars in China embracing the political views of Carl Schmitt. They are aware of the dangerous side of his thought but have provided reasonable analysis in relation to the Chinese social situation. Outlining their discussions, this article will depict the phenomenon with a focus on Schmitt’s controversial political theology. That will be compared with the thought of Dietrich Bonhoeffer. Although their political alignments were opposed to each other, the theoretical structure of their thinking reveals striking similarities. This article will thus articulate the theological reasons that allow for the differences between their ideas and actions and will produce a reflection on the contemporary situation in China. It is not due to the theoretical structure, but to the image of the sovereign embraced, that the stances of the two thinkers differed. From this we may draw implications from a public theological discussion for constructing a democratic society in the context of China.
The Evolving Role of the General Assembly vis-à-vis the Security Council in the Maintenance of Peace
Authors: Barber Rebecca 
Published: May 2023

Abstract
In recent years, the UN Security Council has proved unable to respond to pressing global security crises. The General Assembly has been stepping up, passing robust resolutions including on Syria, Myanmar and Russia/Ukraine, and most recently committing to meet every time a veto is cast in the Security Council.
This article considers whether the Assembly’s recent interventions have altered its position in the UN system vis-à-vis that of the Security Council. It first reviews the Assembly’s powers as described in the UN Charter, then reviews the Assembly’s evolving practice, and then elaborates how, legally, that practice shapes the Assembly’s competence. The article concludes that the Assembly’s recent interventions have not further expanded its powers, but have shifted the status quo pertaining to the relative roles of the General Assembly and Security Council. The final part of the article proceeds on the assumption that we may now look to the Assembly to intervene more routinely in global crises, and considers what we should thus look to the Assembly to usefully do.
Crying Wolf: A Qualitative Review of Misinformation and Conspiracy Theories in Lupus Erythematosus
Authors: Porter Emma , Murphy Michelle , O’Connor Cathal 
Published: May 2023

Background Lupus comprises a complex group of inflammatory disorders including cutaneous lupus erythematosus (CLE) and systemic lupus erythematosus (SLE). The issue of health misinformation is increasingly problematic, although the content of misinformation related to lupus available online has not been deeply explored. This study aimed to qualitatively assess the type of misinformation related to lupus available online. Methods A literature search on PubMed was conducted, using search terms “cutaneous lupus” OR “discoid lupus” OR “lupus” AND “misinformation” OR “conspiracy” OR “disinformation.” Further searches were also performed on Google, YouTube, Twitter, Facebook, Instagram, and TikTok. Results Published literature describing lupus-related misinformation was minimal, with only three manuscripts identified. Conversely, a variety of points of misinformation were identified online and on social media. Key themes identified in online content included suggestion of incorrect causes such as infection or aspartame consumption, false risk assessments such as lupus never developing in males, false claims about conventional treatments, and promotion of alternative treatments or “cures” without evidence. Conclusion Dermatologists, rheumatologists, and all clinicians treating patients with lupus play an essential role in dispelling the pervasive misinformation surrounding the disease and its treatments, encouraging patients to seek reliable sources of information, and advocating for evidence-based guidance.
Non-perfusion severity correlates with central macular thickness and microvascular impairment in branch retinal vein occlusions
Authors: Antropoli Alessio , Bianco Lorenzo , Arrigo Alessandro , Bandello Francesco , Battaglia Parodi Maurizio 
Published: May 2023

Purpose To study peripheral capillary non-perfusion (PCN-P) in branch retinal vein occlusion (BRVO) by means of ultra wide-field fluorescein angiography (UWFFA), and to correlate its extent and severity with optical coherence tomography (OCT) and OCT-angiography (OCTA) parameters and best corrected visual acuity (BCVA). Methods Prospective case series with 2 years of planned follow-up. We recruited patients from June 2019 to December 2019. Ophthalmologic examination included BCVA, UWFFA, OCT and OCTA. Partial (p) and complete (c) ischemic index (ISI) were evaluated on UWFFA images. Vessel density (VD) in both the macular region and the optic nerve head (ONH) was calculated. Results Twelve BRVO subjects and 12 healthy controls were recruited. Mean age was 63.8  ±  8.74 years. Mean BCVA improved from 0.43  ±  0.25 logMAR to 0.15  ±  0.18 after two years (p < 0.01), while mean central macular thickness (CMT) decreased from 463.83  ±  200.85 µm to 353.17  ±  108.85 µm (p > 0.05). Mean cISI, pISI and total ISI were 25.2  ±  13.0%, 6.3  ±  5.0% and 31.5  ±  12.0%, respectively. Except for VDs of the superficial capillary plexus and choriocapillaris in the macular region, all VDs were lower in the BRVO group (p < 0.01). cISI and tISI negatively correlated with mDCP (p < 0.01), whereas only pISI correlated with CMT at baseline (p < 0.05). Additionally, cISI also negatively correlated with VD at the ONH (p < 0.05). Conclusion The amount of complete and partial ischemia may have different implications in BRVO, with the former being more associated with microvascular impairment and the latter with macular edema.
Parents’ expectation of antibiotic prescriptions for respiratory infections in children: a systematic review and meta-analysis
Authors: Shamim Muhammad Aaqib , Padhi Bijaya K. , Satapathy Prakasini , Siddiq Abdelmonem , Manna Subhanwita , Aggarwal Arun K. , Al-Ahdal Tareq , Khubchandani Jagdish , Henao-Martinez Andrés F. , Sah Ranjit 
Published: May 2023

Objectives: Despite most childhood infections being self-limiting, children are among the leading consumers of antibiotics. Little is known about parental expectations of antibiotics for childhood infections. A comprehensive systematic review and meta-analysis was conducted to explore the nature and extent of parental expectations of antibiotic prescriptions for children with respiratory infections. Design: Systematic review and meta-analysis. Methods: An extensive literature search using six major scientific databases was conducted for all published articles until 7 December 2022. Primary studies reporting parents’ expectations of antibiotics for children with upper respiratory tract infections were included after assessment for quality. Heterogeneity between the studies was assessed using the I2 statistic and publication bias was analyzed using funnel plots and Egger regression tests. The primary outcome was a summary estimate of the percentage of parents who expect antibiotics from their physicians when their child presents with an upper respiratory tract infection. Results: From a total of 4510 studies found in the initial searches, a final pool of 19 eligible studies with 15,664 individuals was included in this meta-analysis. Nine of the 19 studies were from the United States or Saudi Arabia. The pooled prevalence of parental expectations of antibiotics in the population reviewed was 55.78% (95% CI = 44.60–66.41). There was significant heterogeneity between the studies, but funnel plot and meta-regression did not detect any publication bias. Conclusion: More than half of parents expect antibiotics for their children during consultation for upper respiratory tract infections. Such practices may cause undue side effects among children, contribute to the growing burden of antibiotic resistance, and lead to treatment failure for many common infections in the future. To optimize efforts to tackle antimicrobial resistance, shared decision-making and education emphasizing the proper and judicious use of antibiotics are much needed in pediatric healthcare settings. This can also help to manage parents’ expectations when seeking antibiotics for their children. Despite pressure from parents, pediatric healthcare providers should continue to advocate for antibiotic use only when warranted and help improve knowledge and awareness amongst parents. Registration: The protocol has been registered with PROSPERO (CRD42022364198)
The orally bioavailable GSPT1/2 degrader SJ6986 exhibits in vivo efficacy in acute lymphoblastic leukemia
Authors: Chang Yunchao , Keramatnia Fatemeh , Ghate Pankaj S. , Nishiguchi Gisele , Gao Qingsong , Iacobucci Ilaria , Yang Lei , Chepyala Divyabharathi , Mishra Ashutosh , High Anthony A. , Goto Hiroaki , Akahane Koshi , Peng Junmin , Yang Jun J. , Fischer Marcus , Rankovic Zoran , Mullighan Charles G. 
Published: May 2023

Abstract
Advancing cure rates for high-risk acute lymphoblastic leukemia (ALL) has been limited by the lack of agents that effectively kill leukemic cells, sparing normal hematopoietic tissue. Molecular glues direct the ubiquitin ligase cellular machinery to target neosubstrates for protein degradation. We developed a novel cereblon modulator, SJ6986, that exhibits potent and selective degradation of GSPT1 and GSPT2 and cytotoxic activity against childhood cancer cell lines. Here, we report in vitro and in vivo testing of the activity of this agent in a panel of ALL cell lines and xenografts. SJ6986 exhibited similar cytotoxicity to the previously described GSPT1 degrader CC-90009 in a panel of leukemia cell lines in vitro, resulting in apoptosis and perturbation of cell cycle progression. SJ6986 was more effective than CC-90009 in suppressing leukemic cell growth in vivo, partly attributable to favorable pharmacokinetic properties, and did not significantly impair differentiation of human CD34+ cells ex vivo. Genome-wide CRISPR/Cas9 screening of ALL cell lines treated with SJ6986 confirmed that components of the CRL4CRBN complex, associated adaptors, regulators, and effectors were integral in mediating the action of SJ6986. SJ6986 is a potent, selective, orally bioavailable GSPT1/2 degrader that shows broad antileukemic activity and has potential for clinical development.
Factors associated with non-invasive positive pressure ventilation failure in a COVID-19 intermediate care unit
Authors: Farinha Inês , da Cunha Alexandra Tenda , Nogueira Ana Rita , Ribeiro André , Silva Carlos , Rua João , Trêpa João , Mateus José Eduardo , Costa Filipa 
Published: May 2023

Abstract
Background
The use of non-invasive positive pressure ventilation (NIPPV) in COVID-19 patients with hypoxaemia is still under debate. The aim was to evaluate the efficacy of NIPPV (CPAP, HELMET-CPAP or NIV) in COVID-19 patients treated in the dedicated COVID-19 Intermediate Care Unit of Coimbra Hospital and University Centre, Portugal, and to assess factors associated with NIPPV failure.

Methods
Patients admitted from December 1st 2020 to February 28th 2021, treated with NIPPV due to COVID-19 were included. Failure was defined as orotracheal intubation (OTI) or death during hospital stay. Factors associated with NIPPV failure were included in a univariate binary logistic regression analysis; those with a significance level of p < 0.001 entered a multivariate logistic regression model.

Results
A total of 163 patients were included, 64.4% were males (n = 105). The median age was 66 years (IQR 56–75). NIPPV failure was observed in 66 (40.5%) patients, 26 (39.4%) were intubated and 40 (60.6%) died during their hospital stay. The highest CRP (OR 1.164; 95%CI 1.036–1.308) and morphine use (OR 24.771; 95%CI 1.809–339.241) were identified as predictors of failure after applying multivariate logistic regression. Adherence to prone positioning (OR 0.109; 95%CI 0.017–0.700) and a higher value of the lowest platelet count during hospital stay (OR 0.977; 95%CI 0.960–0.994) were associated with a favorable outcome.

Conclusions
NIPPV was successful in over half of patients. Highest CRP during hospital stay and morphine use were predictors of failure. Adherence to prone positioning and a higher value of the lowest platelet count during hospital stay were associated with a favourable outcome.
Atypical presentation of bilateral Epstein-Barr virus dacryoadenitis: a case report of corticosteroid resistant orbital inflammation
Authors: Tan Charissa H. , Tauchi-Nishi Pamela S. , Sweeney Adam R. 
Published: May 2023

AbstractEpstein-Barr virus is a known cause of dacryoadenitis that is typically sensitive to corticosteroid treatment. When affecting the orbit, particularly the lacrimal gland, Epstein-Barr virus may cause chronic proptosis and a bilateral lacrimal mass effect. We provide a case of bilateral Epstein-Barr virus associated dacryoadenitis initially resistant to corticosteroid treatment requiring biopsy and confirmation by polymerase chain reaction of lacrimal tissue. Herein, we discuss the presentation with associated magnetic resonance imaging and histopathologic images, diagnostic dilemma, and treatment of an atypical case.
Perovskite quantum dots modulating upconversion nanomaterials for cancer early detections
Authors: He Yue , Rao Hongtao , Wang JingJing , Wu Ying , Han Caiqin , Yan Changchun , Temple Hunter , Zhang Le , Chen Wei , Liu Ying 
Published: May 2023

AbstractThe accurate diagnosis and treatment of cancer cell lesions need a high standard of detection technology. Fluorescent probes to perform cancer biomarker detection have become a popular research issue. However, fluorescent probes still face enormous challenges of complex design and difficult detection. In this work, we propose a novel composite material UCNP@SiO2 + QDs based on the combination of rare earth upconversion (UCNPs) and perovskite quantum dots (QDs) and design a new fluorescent probe MB-UCNP@SiO2 + QDs with molecular beacon (MB) as the carrier, that can be excited by near-infrared light, emitted in the visible wavelength, specifically identified and highly sensitive. Under the excitation of 980 nm near-infrared light, the UCNPs and QDs in the composite produced the maximum efficiency of energy transfer through fluorescence resonance, and the multi-emission light of UCNPs synergistically excited the re-emission of QDs, and the energy transfer efficiency is 70.6%. By changing the doping ratio of QDs halogen elements in UCNP@SiO2 + QDs, it is possible to modulate the precise luminescence of UCNP@SiO2 + QDs in the entire wavelength range of visible light at different positions. The novel fluorescent probe is obtained using UCNP@SiO2 + QDs and Black Hole Quencher-1 (BHQ1) quenching groups linked to the two respective sides of MB, selecting as the target of detection the myeloma cancer biomarker miRNA-155, a difficult diagnostic and complex developmental type, and have achieved specific recognition and low concentration of miRNA-155 and a detection limit of 73.5 pM. This fluorescent probe design can provide new ideas for the early diagnosis and treatment of cancer, tumors, and cardiovascular diseases.
Graphical Abstract
Improving variant calling using population data and deep learning
Authors: Chen Nae-Chyun , Kolesnikov Alexey , Goel Sidharth , Yun Taedong , Chang Pi-Chuan , Carroll Andrew 
Published: May 2023

AbstractLarge-scale population variant data is often used to filter and aid interpretation of variant calls in a single sample. These approaches do not incorporate population information directly into the process of variant calling, and are often limited to filtering which trades recall for precision. In this study, we develop population-aware DeepVariant models with a new channel encoding allele frequencies from the 1000 Genomes Project. This model reduces variant calling errors, improving both precision and recall in single samples, and reduces rare homozygous and pathogenic clinvar calls cohort-wide. We assess the use of population-specific or diverse reference panels, finding the greatest accuracy with diverse panels, suggesting that large, diverse panels are preferable to individual populations, even when the population matches sample ancestry. Finally, we show that this benefit generalizes to samples with different ancestry from the training data even when the ancestry is also excluded from the reference panel.
Congenital absence of the left pericardium: a case report
Authors: Li Xiang-Yi , Jiang Yan , Li Hao-Wen , Liu Yong-Kang , Bai Jing 
Published: May 2023

Abstract
Background
Congenital absence of the pericardium (CAP) is rare in clinical practice, the symptoms vary among patients, and most doctors do not have enough knowledge of the condition. Most reported CAP cases are incidental findings. Therefore, this case report aimed to present a rare case of left partial CAP that presented with non-specific, possibly cardiac-related symptoms.

Case presentation
The patient, male, 56 years old, Asian, was admitted on March 2, 2021. The patient complained of occasional dizziness in the past week. The patient was suffering from hyperlipidemia and hypertension (stage 2), both untreated. The patient reported chest pain, palpitations, discomfort in the precordium, and dyspnea in the lateral recumbent position after strenuous activities, all of which started when he was about 15 years old. ECG showed sinus rhythm, 76 bpm, premature ventricular beats, incomplete right bundle branch block, and clockwise rotation of the electrical axis. Most of the ascending aorta could be detected in the parasternal intercostal space 2–4 by transthoracic echocardiography in the left lateral position. Chest computed tomography revealed the absence of pericardium between the aorta and the pulmonary artery, and part of the left lung was extending into the space. No changes in his condition have been reported up to now (March 2023).

Conclusions
CAP should be considered when multiple examinations suggest heart rotation and a large moving range of the heart in the thoracic cavity.
Sleep duration affects the sequential change of body mass index and muscle strength: a contribution to dynapenic obesity
Authors: Zhang Zeyi , Wang Jingjing , Wang Jingyi , Ma Bin , Jia Yuanmin , Chen Ou 
Published: May 2023

Abstract
Background
With aging, body mass index (BMI) increases and muscle strength declines, resulting in dynapenic obesity. It remains unknown whether and how sleep duration contributes to the sequence of BMI and muscle strength change in the progression of dynapenic obesity.

Methods
Data were derived from the first two waves of China Health and Retirement Longitudinal Study. Sleep duration was self-reported. BMI was calculated and grip strength (GS) was measured to reflect muscle strength. The effect of baseline sleep duration on the sequential change of BMI and GS was assessed using two mediation models considering the nonlinear associations between them. The moderating effect of metabolic disorder was also tested.

Results
Totally 4986 participants aged ≥ 50 years (50.8% females) with complete information on variables were included. Baseline BMI fully mediated the nonlinear association between sleep duration and follow-up GS change, but baseline GS did not mediate between sleep duration and follow-up BMI change for older men and women. Short sleep duration positively affected BMI-induced GS change (β = 0.038; 95%CI, 0.015–0.074), while this favorable effect became nonsignificant for moderate sleep duration (β = 0.008; 95% CI, -0.003–0.024) and turned negative with prolonged sleep duration (β =  − 0.022; 95%CI, − 0.051 to − 0.003). This nonlinear mediation effect was more pronounced in older women who are relatively metabolically healthy at baseline.

Conclusion
For older adults in China, the influence of sleep duration on BMI-induced GS change but not the GS-induced BMI change suggested the contribution of sleep duration to the sequential course in the progression of dynapenic obesity. Sleep duration deviated either above or below normal range may confer adverse impact on GS through BMI. Strategies addressing sleep and obesity jointly to improve muscle function and delay the progression of dynapenic obesity are required.
Indirect effects of the COVID-19 pandemic on risk of gestational diabetes and factors contributing to increased risk in a multiethnic population: a retrospective cohort study
Authors: Rhou Yoon Ji Jina , Elhindi James , Melov Sarah J. , Cheung N. Wah , Pasupathy Dharmintra ,   the Western Sydney COVID-19 Pregnancy Study Group
Published: May 2023

Abstract
Background
The COVID-19 pandemic has had indirect effects on pregnancy outcomes. There is limited data on the impact on gestational diabetes (GDM) in diverse populations and the possible underlying mediators. This study aimed to assess the risk of GDM pre-COVID-19 and in two distinct pandemic exposure periods, and to determine the potential factors contributing to increased risk in a multiethnic population.

Methods
A multicentre, retrospective cohort study was performed of women with singleton pregnancy receiving antenatal care at three hospitals two years pre-COVID-19 (January 2018 – January 2020), first year of COVID-19 with limited pandemic-mitigating restrictions (February 2020 – January 2021) and second year of COVID-19 with stringent restrictions (February 2021 – January 2022). Baseline maternal characteristics and gestational weight gain (GWG) were compared between cohorts. The primary outcome was GDM, assessed using univariate and multivariate generalised estimating equations models.

Results
28,207 pregnancies met the inclusion criteria, 14,663 pregnancies two years pre-COVID-19, 6,890 in COVID-19 Year 1 and 6,654 in COVID-19 Year 2. Maternal age increased across exposure periods (30.7 ± 5.0 years pre-COVID-19 vs 31.0 ± 5.0 years COVID-19 Year 1 vs 31.3 ± 5 years COVID-19 Year 2; p < 0.001). There were increases in pre-pregnancy body mass index (BMI) (25.5 ± 5.7 kg/m2 vs 25.7 ± 5.6 kg/m2 vs 26.1 ± 5.7 kg/m2; p < 0.001), proportion who were obese (17.5% vs 18.1% vs 20.7%; p < 0.001) and proportion with other traditional risk factors for GDM including South Asian ethnicity and prior history of GDM. Rate of GWG and proportion exceeding recommended GWG increased with pandemic exposure (64.3% vs 66.0% vs 66.6%; p = 0.009). GDM diagnosis increased across exposure periods (21.2% vs 22.9% vs 24.8%; p < 0.001). Both pandemic exposure periods were associated with increased risk of GDM on univariate analysis, only COVID-19 Year 2 remaining significantly associated after adjusting for maternal baseline characteristics and GWG (OR 1.17 [1.06, 1.28], p = 0.01).

Conclusions
Diagnosis of GDM increased with pandemic exposure. Progressive sociodemographic changes and greater GWG may have contributed to increased risk. However, exposure to the second year of COVID-19 remained independently associated with GDM after adjusting for shifts in maternal characteristics and GWG.