bluuebunny/crossref_metadata_2025_split huggingface dataset:
A correlation study of serum tumor markers with systemic lupus erythematosus-associated interstitial lung disease
Authors: He Xing , Guo Lu , Ji Jiaqi , Zhou Ting , Luo Zeli , Fang Siyu , Chen Qiqi , Liu Chi , Yan Haiying 
Published: March 2023

Abstract
Background:
Systemic lupus erythematosus-associated interstitial lung disease (SLE-ILD) is one of the manifestations of SLE involvement of the lung, and currently, serum markers are lacking for its early prediction. In this study, we investigated the clinical significance of serum tumor markers (TM) in SLE-ILD to further analyze the potential correlation of serum TM with SLE affected of tissues and organs.
Methods:
Medical records of SLE patients from Sichuan Provincial People's Hospital ＆ University of Electronic Science and Technology of China were retrospectively reviewed. Serum TM including carcinoembryonic antigen (CEA), carbohydrate antigens (CA125, CA15-3, CA19-9), squamous cell carcinoma antigen (SCC), cytokeratin-19-fragment (CYFRA21-1), neuron-specific enolase (NSE), ferritin (FER) from the peripheral blood of SLE patients with or without ILD were compared and analyzed, to investigate their relevance and clinical value in patients with SLE-ILD.
Results:
A total of 927 patients eligible for the diagnosis of SLE were enrolled in this study, and 386 patients with SLE were finally included, including 64 patients with SLE-ILD. Age, and levels of erythrocyte sedimentation rate (ESR), serum lactate dehydrogenase (LDH), and serum creatine kinase (CK) in patients with SLE-ILD were higher than those with SLE (P<0.05). Patients with SLE-ILD had higher serum levels of CEA, CA125, CA15-3, CA19-9, SCC, CYFRA21-1, and FER compared to SLE patients. Results of multivariate regression showed that age [OR=1.038, 95% CI=(1.004,1.074)], CA15-3 [OR=1.099, 95% CI=(1.039,1.162)], and CA19-9 [OR=1.032, 95% CI=(1.005,1.059)] were predictors of SLE-ILD (P <0.05). Among the monitored serum TM, CA125 and CA15-3 possessed good predictive values (area under the receiver operating characteristic curve (AUC) was 0.7 and 0.722, respectively, P<0.05); serum SCC and CYFRA21-1 were moderately positively correlated with serum creatinine (Cr) levels (r value was 0.562 and 0.713, respectively, P<0.001).
Conclusions:
Serum CA125, CA15-3, and CA19-9 can serve as clinical predictive markers for SLE-ILD. In addition to lungs, serum SCC, CYFRA21-1 and FER detected in tumor-related markers may also related to kidney involvement of SLE.It is recommended to strengthen the monitoring and investigation of serum TM in patients with SLE-ILD to discover its potential clinical value.
Experimental evaluation of in-plane seismic demand on Power Actuated Fasteners (PAF) connecting CFS drywall partitions and concrete surrounding elements
Authors: FIORINO Luigi , CAMPICHE Alessia , Grzesik Peter , Landolfo Raffaele 
Published: March 2023

Abstract
The evaluation of the response of Cold-formed Steel (CFS) drywall partitions under in-plane earthquake loading is one of the open tasks for understanding the impact of nonstructural elements on the seismic performance of constructions, especially when the implementation of performance-based earthquake criteria is required. In this context, the evaluation of the seismic demand on fasteners connecting drywall partitions with the surrounding structures has not been well covered. To overcome this gap, a specific experimental study devoted to evaluate the in-plane seismic demand on Power Actuated Fasteners (PAF) connecting CFS drywall partitions and concrete surrounding elements is presented in this paper. In particular, the experimental activity includes seven quasi-static reversed cyclic tests on full-scale drywall partitions. Parameters under investigation are: type of surrounding connections; type of sliding connection; spacing of PAFs. From global point of view, results showed that the main parameter affecting the seismic response of the drywall partitions was the type of surrounding connections. PAFs connecting both studs and tracks to concrete surrounding elements exhibited elastic behaviour without significant damage in all tested walls with seismic demand equal to 0.50 mm in terms of displacement, 1.9 kN in terms of force per single PAF, 4 kN/m in terms of force per unit length of the wall.
Coloration of polyamide-6,6 fabric with carbon black nano particle for camouflage textiles of simultaneous spectrum probe in visible and near infrared
Authors: Hossain Md. Anowar 
Published: March 2023

Abstract
Polyamide 6,6 (PA-6,6) fabric was experimented for liquid phase formulation and coloration in acidic medium of seven standardized PH (0–6) with carbon black nano particle (CBNP). International commission on illumination (CIE) color value (L*, a*, b*), Kubelka-Munk (K-M) reflection and reflection (%) of CBNP dyed PA-6,6 fabric was investigated with optical condition of specular reflectance, color measurement spectrophotometer from 400 nm to 700 nm. The K-M reflection and reflection (%) of CBNP dyed PA-6,6 fabric was also measured with optical property of diffuse reflectance, Fourier transform infrared spectroscopy from 1000 nm to 2500 nm. Visible-near infrared-reflection (%) was observed comparatively lower for PH 4 to 5. Similarly, K-M reflection of simultaneous spectrum probe in visible-near infrared was found higher for PH 4 to 5. Raw CBNP and CBNP modified PA-6,6 fabric was also examined for oxidation property, aggregation property, coloring property and air permeability by scanning electron microscopy. Hence, this experimentation was only focused on color properties of CBNP modified PA-6,6 fabric in terms of camouflage textiles.
Identification of CLDN3 as a Novel Biomarker for Gastric Precancerous Lesions via Comprehensive Bioinformatics and Machine Learning Analysis
Authors: Zhang Qingqing , Liu Nanyang , Wu Di , Xu Zhengyu , Wang Yichen , Wang Ping 
Published: March 2023

Abstract

Gastric cancer (GC) poses a serious threat to human health, and early detection and treatment of Low-grade intraepithelial neoplasia (LGIN) is crucial in preventing its progression to GC. Therefore, it's important to identify decisive diagnostic biomarkers of LGIN for effective treatment selection. To achieve this, we obtained two datasets from the GEO database(GSE130823, GSE55696), using the GSE55696 as a validation set. Our analysis, using various bioinformatics strategies and machine-learning algorithms, led to the identification of 328 differentially expressed genes (DEGs) primarily involved in processes such as organic anion transport, regulation of blood pressure, and cell-cell junction assembly. Our results suggest that CLDN3 is a potentially valuable diagnostic biomarker for LGIN, as determined through algorithms such as LASSO regression, SVM-RFE, and WGCNA, and confirmed through receiver operating characteristic curves and CIBESORT analysis. Our findings indicate that CLDN3 is a reliable diagnostic biomarker for gastric cancer precursors, as confirmed by validation sets and immunohistochemical staining images in HPA. Additionally, we established a TF-CLDN3-miRNA regulatory network, which provides insights into the regulatory mechanisms of CLDN3 in the precancerous process of gastric cancer. We also found that immune cell infiltration may play a crucial role in the development of LGIN, and that CLDN3 has potential regulatory mechanisms in this process.
Understanding the Vicious Circle of Pain, Physical Activity, and Mental Health in Lipedema Patients – a Response Surface Analysis
Authors: Aitzetmüller-Klietz Marie-Luise , Busch Lena , Hamatschek Matthias , Paul Matthias , Schriek Carsten , Wiebringhaus Philipp , Aitzetmüller-Klietz Matthias , Kückelhaus Maximilian , Hirsch Tobias 
Published: March 2023

Abstract
Lipedema is a wide-spread disease with painful accumulations of subcutaneous fat in legs and arms. Often obesity co-occurs. Many patients suffer from impairment in mobility and mental health. Obesity and mental health in turn can be positively influenced by physical activity. In this study we aimed to examine the interrelations between pain and physical activity on mental health in lipedema patients. In total, 511 female lipedema patients (age M = 40.16 ± 12.45 years, BMI M = 33.86 ± 7.80 kg/m2) filled in questionnaires measuring pain (10-point scale), physical activity (7 Items; units per week), and mental health (PHQ-9; WHOQOL-BREF with subscales mental, physical, social, environmental, and overall health). Response surface analyses were calculated via R statistics. Explained variance was high for the model predicting depression severity (R2 = .18, p < .001) and physical health (R2 = .30, p < .001). Additive incongruence effects of pain and physical activity on depression severity, mental, physical, and overall health were found (all p < .001). In our study, physical activity and pain synergistically influenced physical, mental, and overall health. Pain did not only lead to low mental health but also interfered with the valuable potential of engaging in physical activity in lipedema patients.
Validity, reliability and responsiveness to change of the Child Oral Impacts on Daily Performances (C-OIDP) index: a cross-sectional and an intervention study of adolescents in Bosnia and Herzegovina
Authors: Erić Jelena , Bjelović Ljiljana , Janković Svjetlana , Davidović Bojana , Bozović Djordje , Krunić Jelena 
Published: March 2023

Abstract
Background: The clinical measures are not sufficient to assess oral health because they don’t tell us anything about functional and psychosocial aspects of oral health and do not reflect person’s concerns and subjectively perceived symptoms. This study aimed to investigate the validity, reliability and responsiveness to change of the child Oral Impacts on Daily Performances (C-OIDP) index in a Bosnian 12-14 schoolchildren.
Methods: The study population comprised 203 primary schoolchildren aged 12-14 years attending three schools in the eastern part of Bosnia and Herzegovina. Data were collected through: a clinical oral examination, oral health questionnaire and C-OIDP questionnaire. The validity and reliability of the C-OIDP were tested on a sample of 203 school-going children while responsiveness to change of the C-OIDP was assessed on 42 randomly chosen participants requiring a dental treatment.
Results: In terms of reliability, Cronbach’s alpha coefficient and the intraclass correlation coefficient were 0.86 and 0.85, respectively. Regarding the testing of construct validity, the C-OIDP score was increased as children’s self-reported oral health changed from excellent to very bad and from very satisfied to dissatisfied. There was a significant improvement in C-OIDP post-treatment score compared with C-OIDP pre-treatment score. Overall, 63.4% of participants reported at least one oral impact in the last 3 months. The most affected performances were “eating” (38.4%) and “speaking” (25.1%).
Conclusion: The Bosnian version of the C-OIDP showed satisfactory validity, reliability and responsiveness to change and can be used as an appropriate OHRQoL measure for further epidemiological researches.
Research on the influence of WeChat assisted sports education mode on college football teaching from the perspective of big data
Authors: Zhao Peng 
Published: March 2023

Abstract
In the context of the information age, more and more learners prefer to learn by using online learning systems. Online learning can not only meet the needs of learners for collaborative learning and information interaction, but also meet the needs of mobile learning. It can break the time and space constraints and conduct fragmented learning anytime, anywhere. This paper introduces big data technology to conduct teaching design research for football courses. The design objectives of education mode include curriculum, education mode, learner and environment analysis, etc. The overall process is completed based on WeChat applications, and can be combined with collaborative filtering recommendation algorithm to achieve the construction of each system module. The experimental results show that the algorithm has higher computational efficiency. In this study, 80 college football students were selected as the experimental subjects, including 40 female students and 40 male students. They were divided into the control group and the experimental group for six weeks. The experimental items of the control group remained unchanged, while the experimental group added additional skills and tactics, sports knowledge and physical fitness. After the experiment, the effect of college football teaching was analyzed. It can be seen that the experimental group was significantly better than the control group in dribbling skills, and there were significant differences in data comparison. It shows that the sports level of the experimental group has improved significantly after the sports teaching assisted by WeChat, which proves the effect of the sports education assisted by WeChat. This paper improves the efficiency and effect of college football education by combining big data technology with WeChat assisted sports.
In-house processing of Carbon Fiber Reinforced Polyetheretherketone (CFR-PEEK) 3D printable filaments and fused filament fabrication-3d printing of CFR-PEEK parts
Authors: Naganaboyina Harsha P. S. , Nagaraju Phaniteja , Sonaye Surendrasingh Y. , Bokam Vijay K. , Sikder Prabaha 
Published: March 2023

Abstract
PEEK has several approving mechanical properties; however, for certain demanding applications such as automotive, PEEK does not exhibit the required strength. Moreover, if the PEEK parts are developed by Fused Filament Fabrication (FFF)-based 3D Printing, there is a high chance of having PEEK parts with decreased mechanical properties. Carbon Fiber (CF) reinforcement is a well-known method of mitigating the low mechanical properties of PEEK. Hence, in the present study, we attempted to develop CF-reinforced PEEK (CFR-PEEK) parts via FFF. First, we developed homogeneous CFR-PEEK mixtures via ball milling and explored the effects of different milling duration and speeds on the extent of uniform dispersion of the CFs in the PEEK matrix. Next, we fed the CFR-PEEK milled powders into a high-temperature extrusion setup to develop uniform-diameter CFR-PEEK filaments. We analyzed the effects of different extrusion parameters on the uniform-diameter CFR-PEEK filament quality to make it suitable for 3D Printing. Finally, the CFR-PEEK filaments were used in a high-temperature FFF setup to develop design-specific parts. Our results indicate that 400 rpm and 4h were apt for developing uniform CFR-PEEK mixtures. Interestingly, increasing the CF content above 10 vol% resulted in brittle filaments. The extrusion temperature, speed, and cooling rate played a major role in forming the uniform-diameter CFR-PEEK filaments. Finally, the 3D printed CFR-PEEK parts exhibited a tensile strength of 49MPa, lesser than unfilled PEEK. We indicate that poor interfacial bonding of the CF with the PEEK matrix is a primary reason for this reduced strength. In addition, printing defects such as pores also contributed to the reduced strength of the CFR-PEEK parts.
The role of derivations in the nilpotence and semisimpilicity of Lietriple systems
Authors: Abdelwahab Hani , Martin Antonio J. Calderon , Mehanna Moustafa 
Published: March 2023

Abstract
We explore the role derivations of a Lie triple system Τ play in the nilpotence and semisimplicity of T. In particular analogous to two Theorems of Jacobson for Lie algebras, (by giving a sufficient condition for the nilpotence of T in terms of the existence of an invertible derivation, and in terms of the existence of certain automorphisms), are stated. The connections between the Lie algebra of derivations of Τ and the semisimplicity of T are also studied.
AMS Subject Classifications (2020): 17A30, 17A40, 17B30, 17D99, 14D06, 14L30.
Detect malicious websites by building a neural network to capture global and local features of websites
Authors: Zhang Longwen , Yan Qiao 
Published: March 2023

Abstract
Malicious websites are a common way for attackers to steal user data and are a potential security threat to Internet users. With the development of machine learning techniques, malicious website detection methods based on machine learning have been proposed. However, machine learning requires manual extraction of important features and cannot detect unknown features. This leads to unstable and time-consuming predictions. With the development of deep learning, malicious website detection has been achieved by building neural network models. Neural network models can capture high-level information features directly from the data to detect classification. There are still some problems with neural network detection models that affect the accuracy of prediction results. Feature information from malicious websites is not expressed efficiently enough. The model does not capture the feature information of malicious websites well. For this reason, we propose a new malicious website detection model. Our model uses wordpiece-level features to better represent website information. Then, the model will combine the advantages of multi-filter text convolutional neural networks and multi-headed self-attention mechanism in capturing website features. The advantage is that it can capture the global and local features of malicious websites more effectively. The final captured feature vector is detected for classification by a fully connected network. We collected two datasets containing URLs of malicious websites to verify the feature capture capability of our model. From the experimental results, our model obtains 93.08% and 98.52% accuracy on the two datasets, proving the feasibility of the proposed solution.
Vulnerability of smallholder farmers to climate variability in Chiredzi, Zimbabwe
Authors: Zvobgo Luckson , Odoulami Romaric C. , Johnston Peter , Simpson Nicholas P. , Trisos Christopher H. 
Published: March 2023

Abstract

Vulnerability to climate variability and change differs from one group to another, from sector to another, and between regions. Understanding the degree to which smallholder farmers are vulnerable to climate risk is critical when assessing adaptation responses to offset current and future risks. Here, we assessed the vulnerability of smallholder farmers to climate variability in Chiredzi, Zimbabwe. Vulnerability is assessed using a two-dimensional approach – quantitative analysis of observed climate data to assess farmers’ exposure and qualitative analysis of farmers’ socio-economic data. The Livelihood Vulnerability Index (LVI) is applied to understand levels of farmers’ livelihood vulnerability. 16 rainfall and temperature indices and extreme events critical to rainfed smallholder farmers were analysed at annual and seasonal scales from 1972–2021. A cross-sectional survey was conducted on 100 smallholder farmers. Our results confirm an increased warming trend, and forward shift of the rainy season onset, with both of these indices showing statistically significant trends. A maximum temperature increase of 0.1 oC annum-1 was observed. All the other indices and extreme events exhibited insignificant trends. The total seasonal rainfall has increased by 3.2 mm annum-1. Increased interseasonal variability of the measured indices was observed. Hot days for maize and sorghum have increased by 0.25 and 0.85 days annum-1 respectively. The combination of increased delayed rainy season onset and a decreasing trend for rainy season length suggests that the rainy season is shrinking slowly. There was alignment between farmers’ perceptions of the climate and trends from observed climate data on the majority (seven) of the indices. Livelihood vulnerability to climate risk varied for farmers in communal and resettled wards. Farmers in resettled areas had a higher LVI (0.4076) than farmers in communal areas (0.3762). The LVI-IPCC shows a relatively similar index for both communal and resettled wards (-0.0874 and -0.0849 respectively). Importantly, farmers with Indigenous knowledge (IK) and local knowledge (LK) background showed lower LVI than farmers without IK and LK, implying the important role of IK and LK, in climate vulnerability assessment and in increasing farmers’ adaptive capacity. Our results have implications on the implementation of climate adaptation responses by smallholder farmers in Chiredzi. Adaptation measures should be tailored based on the vulnerability levels of farmers and their exposure to climate risks. This is important for the implementation of effective climate adaptation responses in the Chiredzi district.
Health-Related Quality of Life and Impact of Socioeconomic Status among Primary and Secondary School Students after the third COVID-19 Wave in Berlin, Germany
Authors: Kern Mascha , Glatz Toivo , Mall Marcus A. , Seybold Joachim , Kurth Tobias , Mockenhaupt Frank P. , Theuring Stefanie 
Published: March 2023

Abstract

In the earlier phases of the COVID-19 pandemic, studies in Germany and elsewhere found an overall reduction in health-related quality of life (HRQoL) among students. However, there is little evidence on later pandemic stages as well as socioeconomic influencing factors. We aimed to 1) describe HRQoL in a Berlin student cohort at two time points in mid-2021, and to 2) analyze the effects of household income and education. We assessed HRQoL of students from 24 randomly selected primary and secondary schools in Berlin, Germany with the KIDSCREEN-10 index in June and September 2021. To adjust for non-response bias, inverse probability weighting was applied. The potential effects of both household income and education (lower vs. higher) were estimated in generalized linear mixed models, based on prior assumptions presented in directed acyclic graphs. Our cohort comprised 660 students aged 7-19 years. In June 2021, 11.3% reported low HRQoL, whereas in September 2021, this increased to 13.7%, with adolescent girls more frequently reporting low HRQoL than boys and younger children at both time points (20% and 29%). While there was no statistically significant total effect of lower household income on HRQoL, a negative effect of lower household education was statistically significant (β= -2.15, SE = 0.95, 95% CI = -4.01 to -0.29,p= 0.024). In summary, students’ HRQoL in mid-2021 was better than that documented in other studies conducted at pandemic onset. Female adolescents reported low HRQoL more often, and lower household education significantly reduced children's HRQoL. Support strategies for psychosocial wellbeing should consider socioeconomically disadvantaged children as important target groups.
DsRNA sequencing revealed previously missed terminal sequence of an ssRNA virus that infects dinoflagellate Heterocapsa circularisquama
Authors: Takahashi Michiko , Masuda Yuichi , Chiba Yuto , Urayama Syun-ichi , Nagasaki Keizo 
Published: March 2023

Abstract
Heterocapsa circularisquama RNA virus (HcRNAV) is the only dinoflagellate-infecting RNA virus cultured. However, only two strains of HcRNAV have been registered with complete genome sequences (strains 34 and 109 for UA and CY types, respectively). To extend the genomic information of HcRNAV, we performed full-genome sequencing of an unsequenced strain of HcRNAV (strain A8) using the fragmented and primer ligated double-stranded RNA (dsRNA) sequencing (FLDS) method. The complete genome of HcRNAV A8 with 4457 nucleotides (nt) was successfully determined, and sequence alignment of the major capsid protein gene suggested that A8 was a UA type strain, consistent with its intraspecific host specificity. The complete sequence was found to be 80 nt longer at the 5’ terminus than the registered sequences of HcRNAV strains, suggesting that FLDS is more reliable for determining the terminal sequence than conventional methods (5’ Rapid Amplification of cDNA End). Our study contributes to a better understanding of dinoflagellate-infecting viruses with limited sequence data.