bluuebunny/crossref_metadata_2025_split huggingface dataset:
sST2: A Bridge Between Sirt1/p53/p21 Signal-Induced Senescence and TGF-β1/Smad2/3 Regulation of Cardiac Fibrosis in Mouse Viral Myocarditis
Authors: Tan Jiajia , Wei Jing , Lu Hongxiang 
Published: April 2023

AbstractSoluble interleukin 1 receptor-like 1 (sST2) is a novel predictor of poor outcomes, which is involved in inflammatory response and fibrosis of myocarditis. Cellular senescence is a state of irreversible cell cycle arrest. Studies have shown that senescence of myofibroblasts can limit or reduce cardiac fibrosis. However, the molecular mechanism of sST2 regulating cellular senescence is still unclear. Here, we investigate the role of sST2 on cellular senescence in cardiac fibrosis. Our results found that sST2 was upregulated in coxsackievirus group B type 3 (CVB3)-induced viral myocarditis (VMC), which correlated with the expression of senescence markers. In vitro, sST2 activated TGFβ signaling through the phosphorylation of the SMAD complex to induce mouse cardiac fibroblast (MCF) activation and inhibit cellular senescence by the Sirt1/p53/p21 signaling pathway. In vivo, anti-ST2 mAb attenuated CVB3-induced cardiac fibrosis. Our findings elucidate a crucial mechanism underlying through which sST2 inhibits cellular senescence and regulates MCF activation, providing a potential treatment strategy for cardiac fibrosis.
Polymeric smart coatings containing modified capped halloysite nanotubes for corrosion protection of carbon steel
Authors: Habib Sehrish , Khan Adnan , Ismail Salman M. , Shakoor R. A. , Kahraman Ramazan , Ahmed Elsadig Mahdi 
Published: April 2023

AbstractA newly designed smart self-healing epoxy coating system comprised of modified halloysite nanotubes (HNTs) having capping is proposed for corrosion protection of steel. In the first step, HNTs were loaded with 8-hydroxyquinoline (8HQ), used as a corrosion inhibitor. Then the HNTs were sealed/capped using cobalt (II), aiming for an efficient and controlled release of the loaded inhibitor. The smart coatings were developed by reinforcing loaded HNTs into the epoxy matrix. The structural, thermal, mechanical, and electrochemical properties of capped modified HNTs and smart coatings were studied using various techniques. UV–Vis analysis depicted that the capping of the metal-inhibitor complex was decomposed at acidic pH resulting in a controlled release of the loaded inhibitor into HNTs. Electrochemical impedance spectroscopic (EIS) analysis of blank and smart coatings demonstrated that the low-frequency impedance modulus of smart coatings is 109 Ω.cm2 for 20 days compared to blank coatings (105 Ω.cm2), reflecting their excellent corrosion inhibition performance. The superior corrosion protection properties of these smart coatings can be ascribed to the controlled and efficient release of the loaded inhibitor from the capped HNTs. Finally, X-ray photoelectron spectroscopy (XPS) analysis of the steel substrate after the corrosion analysis revealed the adsorption of 8HQ on the steel surface, confirming the formation of iron complex due to the release of loaded inhibitor. This work demonstrated the adeptness of 8HQ in mitigating the corrosion due to the controlled and effective release of the inhibitor from capped HNTs because of dissociation of the metal-inhibitor complex (Co-8HQ).
Graphical abstract
Oyster shell-derived nano-hydroxyapatite and proanthocyanidin pretreatment on dentinal tubule occlusion and permeability before and after acid challenge—an in vitro study
Authors: Bhavan Ram Udatha , Sujatha Venkatappan , Vidhya Sampath , Jayasree Raghavan , Mahalaxmi Sekar 
Published: April 2023

AbstractThis in vitro study evaluated the dentinal tubule occlusion (TO), depth of penetration (DoP), and dentin permeability (DP) of oyster shell-derived nanohydroxyapatite (os-nHAp) with and without 15% proanthocyanidin (PA) pretreatment. os-nHAp was synthesized via the precipitation method and it was characterized. The morphology and particle size of os-nHAp were analyzed using a high-resolution transmission electron microscope (HRTEM). Cytotoxicity of os-nHAp, PA/os-nHAp, and casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) was assessed by (3-(4,5-dimethythiazol-2-yl) 2,5-diphenyl tetrazolium bromide (MTT) assay using human osteosarcoma (MG-63) cell line. One hundred and ninety-seven dentin discs of 3 mm thickness were prepared from the crown portion of extracted human teeth. The dentinal surfaces of the discs were etched for 2 min with 6% citric acid to simulate dentin hypersensitivity. Five discs were randomly selected and the patency of dentinal tubules was confirmed using a scanning electron microscope (SEM). The remaining 192 discs were divided into four groups (n = 48) depending on the type of remineralization as follows: group 1: os-nHAp, group 2: PA/os-nHAp, group 3: CPP-ACP, and group 4: no treatment. The remineralization protocol was followed for 21 days. Out of the 48 dentin discs in each group, 32 discs were used to evaluate dentinal tubule occlusion (TO) and depth of penetration (DoP) using SEM. The remaining 16 discs were subjected to an assessment of dentin permeability (DP) using a hydraulic conductance model. TO, DoP and DP were evaluated after remineralization and acid challenge. Characterization studies confirmed the presence of pure phase apatite. HRTEM confirmed the nanometric particle size of os-nHAp. MTT assay results showed that all the tested materials exhibited >80% cell viability when tested up to a concentration of 100 µg/mL. The results demonstrated a significantly higher mean percentage of TO, DoP, and lesser mean DP after remineralization in groups 1, 2, and 3 (p < 0.05). After the acid challenge, group 3 showed a significant reduction in TO and DoP, and increased DP (p < 0.05). However, no such changes were observed in groups 1 and 2. Within the limitations of this study, it can be concluded that os-nHAp and PA/os-nHAp could serve as potential and durable therapeutic agents in the treatment of dentin hypersensitivity.Graphical Abstract
Design and Development of Inexpensive Paper-Based Chemosensors for Detection of Divalent Copper
Authors: Geetha Mithra , Sadasivuni Kishor Kumar , Al-Ejji Maryam , Sivadas Nandagopal , Bhattacharyya Bagmita , Musthafa Farzana N. , Alfarwati Sarya , Promi Tamanna Jannat , Ahmad Sumayya Ali , Alabed Sara , Hijazi Dima Anwar , Alsaedi Fatimatulzahraa , Al-Shaibah Faozia Nasser 
Published: April 2023

Abstract
Simple, portable, and low-cost paper-based sensors are alternative devices that have the potential to replace high-cost sensing technologies. The compatibility of the paper base biosensors for both chemical and biochemical accentuates its feasibility for application in clinical diagnosis, environmental monitoring, and food quality monitoring. High concentration of copper in blood serum and urine is associated with diseases like liver diseases, carcinomas, acute and chronic infections, rheumatoid arthritis, etc. Detection of copper concentration can give an early sign of Alzheimer disease. Apart from that genetic Wilson's disease can be detected by evaluating the concentration of copper in the urine. In view of the above advantages, a novel and the highly sensitive paper-based sensor has been designed for the selective detection of Cu2+ ions. The fast and highly sensitive chemiresistive multi-dye system sensor can detect Cu2+ ions selectively in as low as 2.23 ppm concentration. Least interference has been observed for counter ion in the detection of Cu2+. Copper chloride, nitrate, and acetate were used to validate the detection process. This assay provides a very high selectivity of Cu2+ ion over other metal cations such as Na+, Mg2+, Ca2+, etc. The easy preparation and high stability of dye solutions, easy functionalization of the paper-based sensors, high selectivity over other cations, low interference of counter anion, and significantly low detection limit of 2.23 ppm make it an effective Cu2+ ion sensor for real-time application in near future.

Graphical Abstract
Equity in Economic Evaluations of Early Childhood Development Interventions in Low-and Middle-Income Countries: Scoping Review
Authors: Baek Yeji , Ademi Zanfina , Fisher Jane , Tran Thach , Owen Alice 
Published: April 2023

Abstract
Objectives
This study aimed to examine how equity is integrated into economic evaluations of early childhood development interventions in low-and middle-income countries (LMICs), and to narratively synthesize the study characteristics and findings.

Methods
We conducted a scoping review by searching three electronic databases with terms including equity, early childhood development intervention, economic evaluation, and LMICs. Interventions that aimed to improve child cognitive, physical, language, motor, or social and emotional development through health, nutrition, security and safety, responsive caregiving, and early learning interventions between conception and age 8 years were considered. Studies published in English peer-reviewed journals in the year 2000 and later were included.

Results
The review included 24 cost-effectiveness studies out of 1460 identified articles based on eligibility criteria. The included studies addressed health, nutrition, social protection, and water, sanitation and hygiene interventions for child development. The common type of intervention was immunization. Mostly, equity was measured using household wealth or geographic areas, and the study findings were presented through subgroup analyses. The study settings were LMICs, but most studies were conducted by research teams from high-income countries. Overall, 63% of included studies reported that early childhood development interventions improved equity with greater intervention benefits observed in disadvantaged groups.

Conclusions
Consideration of equity in evaluations of early childhood interventions provides a more complete picture of cost-effectiveness, and can improve equity. Greater focus on promoting equity consideration, multi-sectoral interventions, and researchers in LMICs would support evidence-based interventions and policies to achieve equity in child development.
Activation of Ca2+ transport in cardiac microsomes enriches functional sets of ER and SR proteins
Authors: Cala Steven E. , Carruthers Nicholas J. , Stemmer Paul M. , Chen Zhenhui , Chen Xuequn 
Published: April 2023

AbstractThe importance of sarcoplasmic reticulum (SR) Ca2+-handling in heart has led to detailed understanding of Ca2+-release and re-uptake protein complexes, while less is known about other endoplasmic reticulum (ER) functions in the heart. To more fully understand cardiac SR and ER functions, we analyzed cardiac microsomes based on their increased density through the actions of the SR Ca2+-ATPase (SERCA) and the ryanodine receptor that are highly active in cardiomyocytes. Crude cardiac microsomal vesicles loaded with Ca oxalate produced two higher density subfractions, MedSR and HighSR. Proteins from 20.0 μg of MV, MedSR, and HighSR protein were fractionated using SDS-PAGE, then trypsinized from 20 separate gel pieces, and analyzed by LC–MS/MS to determine protein content. From 62,000 individual peptide spectra obtained, we identified 1105 different proteins, of which 354 were enriched ≥ 2.0-fold in SR fractions compared to the crude membrane preparation. Previously studied SR proteins were all enriched, as were proteins associated with canonical ER functions. Contractile, mitochondrial, and sarcolemmal proteins were not enriched. Comparing the levels of SERCA-positive SR proteins in MedSR versus HighSR vesicles produced a range of SR subfraction enrichments signifying differing levels of Ca2+ leak co-localized in the same membrane patch. All known junctional SR proteins were more enriched in MedSR, while canonical ER proteins were more enriched in HighSR membrane. Proteins constituting other putative ER/SR subdomains also exhibited average Esub enrichment values (mean ± S.D.) that spanned the range of possible Esub values, suggesting that functional sets of proteins are localized to the same areas of the ER/SR membrane. We conclude that active Ca2+ loading of cardiac microsomes, reflecting the combined activities of Ca2+ uptake by SERCA, and Ca2+ leak by RyR, permits evaluation of multiple functional ER/SR subdomains. Sets of proteins from these subdomains exhibited similar enrichment patterns across membrane subfractions, reflecting the relative levels of SERCA and RyR present within individual patches of cardiac ER and SR.
Postpartum quality of life and associated factors: a cross-sectional study
Authors: Al Rehaili Bushra O. , Al-Raddadi Rajaa , ALEnezi Nadiyah Karim , ALYami Ala H. 
Published: April 2023

Abstract
Purpose
To determine factors associated with postpartum quality of life (QOL).

Methods
An analytic cross-sectional design was used in this study, and data was collected from December 2019 to March 2020. Participants were 252 postpartum women visiting eight governmental primary healthcare centers in Madinah city, Saudi Arabia. Data were collected using a sociodemographic questionnaire, the World Health Organization Quality of Life Assessment-BREF, Multidimensional Scale of Perceived Social Support (MSPSS), and Edinburgh Postnatal Depression Scale. Sleep problems were assessed using an item from the Prime-MD Patient Health Questionnaire.

Results
Maternal age between 26 and 35 years had a significant independent association with the physical health domain of QOL (p < .01). Postpartum depression was significantly associated with lower QOL in all dimensions (p < .01). In addition, sleep problems were associated with three out of the four QOL domains (p < .05). The significant other subscale of the MSPSS was significantly associated with higher QOL scores in all dimensions (p < .01); additionally, family and friends subscales of the MSPSS were significantly associated with the social domain of QOL (p < .01).

Conclusions
Maternal QOL, during the postpartum period, showed negative associations with age, postpartum depression, and sleep disturbances. Ultimately, social support appeared to be an essential factor in mothers’ ability to cope with the physical and psychological problems experienced during this period.
Scaffolding self-regulated learning from causal-relations texts: Diagramming and self-assessment to improve metacomprehension accuracy?
Authors: Pijeira-Díaz Héctor J. , van de Pol Janneke , Channa Faisal , de Bruin Anique 
Published: April 2023

AbstractThe accuracy of students’ relative comprehension judgments when reading texts is typically rather low. This has been ascribed to students grounding their comprehension judgments on cues that are not diagnostic of their actual comprehension level. Asking students to complete causal diagrams—a diagramming scaffold—before judging comprehension has proved effective in providing them with more diagnostic cues and thereby fostered metacomprehension accuracy and self-regulated learning. However, there is still room for improvement. We investigated experimentally whether adding the instruction to students to self-assess their causal diagrams: (1) would lead to more accurate judgments than comprehension judgments, (2) would boost their utilization of diagnostic diagram cues by increasing the saliency of those cues, and (3) would enhance metacomprehension accuracy. Participants (N = 427 secondary students in The Netherlands) were randomly assigned to one of three conditions, namely (1) only diagram completion, (2) diagram completion plus diagram self-assessment, or a (3) filler task after reading (control). Self-assessments were more accurate than comprehension judgments, while both correlated strongly. However, no significant differences were found between diagramming conditions concerning diagram cue utilization and metacomprehension accuracy. Apparently, students self-assess their diagrams even without instruction to do so. Nonetheless, the effect of the diagramming scaffold for improving relative metacomprehension accuracy was replicated and extended to absolute metacomprehension accuracy.
The application of complex network theory for resilience improvement of knowledge-intensive supply chains
Authors: Chen Jiakuan , Wen Haoyu 
Published: April 2023

AbstractWith frequent political conflicts and public health emergencies, global supply chains are constantly under risk interference, significantly reducing supply chain resilience (SCR), especially for the knowledge-intensive supply chains (KISCs). To assess and improve the resilience of KISC, this paper uses complex network theory to construct a directed weighted network model suitable for KISC and expresses the SCR as a comprehensive capability that can resist risk and recover from it. Using quantitative indicators plus qualitative assessment to quantify the resilience index and identify the network key nodes. Two resilience improvement paths are proposed for KISCs, improving firms’ development capacity and industrial backup. In the case study, the resilience of the integrated circuit (IC) supply chain is assessed and improved according to real data from the global IC industry. The findings show that (i) The resilience assessment based on the directed weighted network aligns with industrial reality. (ii) Improving firms’ development capability and industrial backup can improve SCR. (iii) Effective improvement of resilience requires targeting key nodes in the supply chain network (SCN). Moreover, the degree of firms’ development capability improvement and industrial backup intensity should be within a specific range.
Psidium or Myrcia? — The problematic lectotypification of Mitranthes O.Berg (Myrteae, Myrtaceae)
Authors: Proença Carolyn E. B. , Lucas Eve J. 
Published: April 2023

SummaryThe genus Mitranthes (Myrteae, Myrtaceae) was described with five species, but no indication of a generic type. These five species are now known to belong to the independent generic lineages Psidium and Myrcia of the tribe Myrteae. This paper traces the taxonomic and nomenclatural history of Mitranthes, showing that the most appropriate type species is currently accepted in Psidium. As a result, Mitranthes should correctly be treated as a synonym of Psidium and its recent synonymisation in Myrcia must be discounted.
Coincidence of plasma cell leukemia and COVID-19: a diagnostic pitfall
Authors: Egger Margot , Black Anne , Robier Christoph 
Published: April 2023

AbstractWe report the case of a 66-year-old man with a known history of IgD multiple myeloma (MM) which was admitted to hospital because of acute renal failure. Routine PCR testing on admission yielded a positive result for SARS-CoV-2 infection. Examination of the peripheral blood (PB) smear revealed 17% lymphoplasmacytoid cells and a few small plasma cells mimicking morphological changes frequently seen in viral diseases. However, flow cytometric examination showed 20% clonal lambda-restricted plasma cells being consistent with a diagnosis of secondary plasma cell leukemia. Circulating plasma cells as well as similar appearing lymphocyte subtypes such as plasmacytoid lymphocytes are frequently observed in infectious disorders such as COVID-19, so that the lymphocyte morphology in our patient’s case could have been easily misinterpreted as typical COVID-19-induced changes. Our observation highlights the importance of incorporating clinical, morphological, and flow-cytometric data in distinguishing between reactive and neoplastic lymphocyte changes because misinterpretation may affect disease classification and, beyond that, clinical decision-making, which may have serious consequences for patients.
Choose what suits you best: reproductive patterns and livestock management in the Iron Age Iberian Peninsula (3rd c. BC)
Authors: Messana Chiara , Tornero Carlos , Colominas Lídia 
Published: April 2023

AbstractIsotopic analyses have proven to be an essential tool for obtaining more comprehensive and precise knowledge about past livestock strategies. Nevertheless, biogeochemical data for the Iron Age and, in particular, for the Iberian Peninsula are still very scarce. This study aims to provide a first and pivotal glimpse of sheep reproductive strategies adopted by north-eastern Iberian societies during the Middle and Late Iron Age, a period in which a process of urbanisation and agricultural expansion took place. Birth seasonality and the duration of the lambing period are here investigated through sequential oxygen isotope analyses performed on sheep’s second and third lower molars from four relevant Catalan sites (Mas Castellar de Pontós, Tossal de Baltarga, Sant Esteve d’Olius, Turó de la Rovira). These are contemporary (third century BC) and are located in different ecological and cultural areas. Results display diversified sheep reproductive patterns and distinct demographical management in the four settlements, with manipulations both on the season and on the duration of the lambing period. Thus, we propose that herd management and exploitation were determined by specific economic demands and the social organisation and environmental conditions of each area. Therefore, through this biogeochemical approach, we have been able to demonstrate that the resources, knowledge and time involved in the organisation of sheep husbandry were much more complex and planned than classical zooarchaeological studies have so far documented, highlighting the importance of livestock farming as a key activity in the economy of the Iron Age Iberian communities.
How tiny species can be overlooked: the finding of Eudendrium capillaroides (Cnidaria, Hydrozoa) in the Strait of Gibraltar
Authors: González-Duarte Manuel M. , Megina Cesar , López-González Pablo J. 
Published: April 2023

AbstractEudendrium capillaroidesSchuchert, 2008 has not been reported since its original description. The new and abundant material found in Ceuta, southern coast of the Strait of Gibraltar, allows us to refine the morphological diagnosis of this species.Eudendrium capillaroidesis characterized by small monosiphonic colonies, a dense ring at the base of the hydranth, and it seems to have a preference for growing on other hydroids. Male gonophores on atrophied polyps, two-chambered (occasionally one chamber), and female gonophores on reduced polyps in the initial stages of development but hydrants later completely atrophied. Nematocysts are heterotrichous microbasic euryteles of two size classes, a larger size densely distributed in a band on the hydrant body basally and a smaller size abundant mainly on the tentacles. Furthermore, we carried out molecular analyses to assess the status ofE. capillaroidesand its most similar congenerE. capillarewithin the genusEudendrium. The use of few morphological characters or incomplete descriptions may thus lead to an incorrect wide distribution of a nominal species that actually represents a species complex. This can particularly be the case in less conspicuous species, such as many hydroids, where the degree of diversity might be underestimated. The accurate description of tiny, inconspicuous and/or cryptic species is important in order to better estimate global marine diversity as well as to understand marine communities and the relationships between their components.