bluuebunny/crossref_metadata_2025_split huggingface dataset:
Crucial neuroprotective roles of the metabolite BH4 in dopaminergic neurons
Authors: Cronin Shane J. F. , Yu Weonjin , Hale Ashley , Licht-Mayer Simon , Crabtree Mark J , Korecka Joanna A. , Tretiakov Evgenii O. , Sealey-Cardona Marco , Somlyay Mate , Onji Masahiro , An Meilin , Fox Jesse D. , Turnes Bruna Lenfers , Gomez-Diaz Carlos , da Luz Scheffer Débora , Cikes Domagoj , Nagy Vanja , Weidinger Adelheid , Wolf Alexandra , Reither Harald , Chabloz Antoine , Kavirayani Anoop , Rao Shuan , Andrews Nick , Latremoliere Alban , Costigan Michael , Douglas Gillian , Freitas Fernando Cini , Pifl Christian , Walz Roger , Konrat Robert , Mahad Don J. , Koslov Andrey V. , Latini Alexandra , Isacson Ole , Harkany Tibor , Hallett Penelope J. , Bagby Stefan , Woolf Clifford J. , Channon Keith M. , Je Hyunsoo Shawn , Penninger Josef M. 
Published: May 2023

AbstractDopa-responsive dystonia (DRD) and Parkinson’s disease (PD) are movement disorders caused by the dysfunction of nigrostriatal dopaminergic neurons. Identifying druggable pathways and biomarkers for guiding therapies is crucial due to the debilitating nature of these disorders. Recent genetic studies have identified variants of GTP cyclohydrolase-1 (GCH1), the rate-limiting enzyme in tetrahydrobiopterin (BH4) synthesis, as causative for these movement disorders. Here, we show that genetic and pharmacological inhibition of BH4 synthesis in mice and human midbrain-like organoids accurately recapitulates motor, behavioral and biochemical characteristics of these human diseases, with severity of the phenotype correlating with extent of BH4 deficiency. We also show that BH4 deficiency increases sensitivities to several PD-related stressors in mice and PD human cells, resulting in worse behavioral and physiological outcomes. Conversely, genetic and pharmacological augmentation of BH4 protects mice from genetically- and chemically induced PD-related stressors. Importantly, increasing BH4 levels also protects primary cells from PD-affected individuals and human midbrain-like organoids (hMLOs) from these stressors. Mechanistically, BH4 not only serves as an essential cofactor for dopamine synthesis, but also independently regulates tyrosine hydroxylase levels, protects against ferroptosis, scavenges mitochondrial ROS, maintains neuronal excitability and promotes mitochondrial ATP production, thereby enhancing mitochondrial fitness and cellular respiration in multiple preclinical PD animal models, human dopaminergic midbrain-like organoids and primary cells from PD-affected individuals. Our findings pinpoint the BH4 pathway as a key metabolic program at the intersection of multiple protective mechanisms for the health and function of midbrain dopaminergic neurons, identifying it as a potential therapeutic target for PD.
Enhancing Collaborative Neuroimaging Research: Introducing COINSTAC Vaults for Federated Analysis and Reproducibility
Authors: Martin Dylan , Basodi Sunitha , Panta Sandeep , Rootes-Murdy Kelly , Prae Paul , Sarwate Anand D. , Kelly Ross , Romero Javier , Baker Bradley T. , Gazula Harshvardhan , Bockholt Jeremy , Turner Jessica , Esper Nathalia B. , Franco Alexandre R. , Plis Sergey , Calhoun Vince D. 
Published: May 2023

ABSTRACTCollaborative neuroimaging research is often hindered by technological, policy, administrative, and methodological barriers, despite the abundance of available data. COINSTAC is a platform that successfully tackles these challenges through federated analysis, allowing researchers to analyze datasets without publicly sharing their data. This paper presents a significant enhancement to the COINSTAC platform: COINSTAC Vaults (CVs). CVs are designed to further reduce barriers by hosting standardized, persistent, and highly-available datasets, while seamlessly integrating with COINSTAC’s federated analysis capabilities. CVs offer a user-friendly interface for self-service analysis, streamlining collaboration and eliminating the need for manual coordination with data owners. Importantly, CVs can also be used in conjunction with open data as well, by simply creating a CV hosting the open data one would like to include in the analysis, thus filling an important gap in the data sharing ecosystem. We demonstrate the impact of CVs through several functional and structural neuroimaging studies utilizing federated analysis showcasing their potential to improve the reproducibility of research and increase sample sizes in neuroimaging studies.
RNase H genes cause distinct impacts on RNA:DNA hybrid formation and mutagenesis genome-wide
Authors: Schroeder Jeremy W. , Hurto Rebecca L. , Randall Justin R. , Wozniak Katherine J. , Timko Taylor A. , Nye Taylor M. , Wang Jue D. , Freddolino Peter L. , Simmons Lyle A. 
Published: May 2023

ABSTRACTRNA:DNA hybrids such as R-loops affect genome integrity and DNA replication fork progression. The overall impacts of naturally occurring RNA:DNA hybrids on genome integrity, and the relative contributions of ribonucleases H to mitigating the negative effects of hybrids, remain unknown. Here, we investigate the contributions of RNases HII (RnhB) and HIII (RnhC) to hybrid removal, DNA replication, and mutagenesis genome-wide. Deletion of eitherrnhBorrnhCtriggers RNA:DNA hybrid accumulation, but with distinct patterns of mutagenesis and hybrid accumulation. Across all cells, hybrids accumulate most strongly in non-coding RNAs and 5′-UTRs of coding sequences. For ΔrnhB, hybrids accumulate preferentially in untranslated regions and early in coding sequences. Hybrid accumulation is particularly sensitive to gene expression in ΔrnhC; in cells lacking RnhC, DNA replication is disrupted leading to transversions and structural variation. Our results resolve the outstanding question of how hybrids in native genomic contexts interact with replication to cause mutagenesis and shape genome organization.
Prior context and individual alpha frequency (IAF) influence predictive processing during language comprehension
Authors: Jano Sophie , Cross Zachariah , Chatburn Alex , Schlesewsky Matthias , Bornkessel-Schlesewsky Ina 
Published: May 2023

AbstractThe extent to which the brain predicts upcoming information during language processing remains controversial. To shed light on this debate, the present study reanalysed Nieuwland and colleagues’ (2018) replication of DeLong et al. (2005). Participants (N= 356) viewed sentences containing articles and nouns of varying predictability, while their electroencephalogram was recorded. We measured event-related potentials (ERPs) preceding the critical words (namely the semantic prediction potential; SPP), in conjunction with post-word N400 patterns and individual neural metrics. ERP activity was compared with two measures of word predictability: cloze probability and lexical surprisal. In contrast to prior literature, SPP amplitudes did not increase as cloze probability increased, suggesting that the component may not reflect prediction during natural language processing. Initial N400 results at the article provided evidence against phonological prediction in language, in line with Nieuwland and colleagues’ findings. Strikingly however, when the surprisal of the prior words in the sentence was included in the analysis, increases in article surprisal were associated with increased N400 amplitudes, consistent with prediction accounts. This relationship between surprisal and N400 amplitude was not observed when the surprisal of the two prior words was low, suggesting that expectation violations at the article may be overlooked under highly predictable conditions. Individual alpha frequency (IAF) also modulated the relationship between article surprisal and the N400, emphasising the importance of individual neural factors for prediction. The present study extends upon existing neurocognitive models of language and prediction more generally, by illuminating the flexible and subject-specific nature of predictive processing.
Drivers of customers' efforts to cope with wearable device usage problems and the role of demographics in a study in China
Authors: Ren Tianbao , Le Hoang T.P.M. , Park Jungkun 
Published: May 2023

PurposeThis study aims to investigate determinants such as performance expectancy (PE), health beliefs (HB), technological compatibility, trust and social influence (SI) of customers' efforts to cope with problems associated with using wearable health technology, thereby determining their use intention of such products. The moderating effect of the demographic variables is also investigated.Design/methodology/approachAn online survey was used to collect panel data from 285 respondents in China. Structural equation modeling was used to test the hypotheses, and interaction moderation was applied to test the moderating effect of the demographic variables.FindingsThe results show that HB, technological compatibility, trust and SI significantly impact coping efforts associated with usage, which significantly influences intention to use. Only income significantly moderated the effect of coping efforts on the intention to use.Originality/valueThis is the first study combining coping theory and UTAUT to develop a model of drivers that encourages customers to overcome the constraints of using wearable technologies.
Diversity–performance nexus in an emerging economy: an investigation of family and non-family firms
Authors: Islam Md Tariqul , Saha Shrabani , Rahman Mahfuzur 
Published: May 2023

PurposeThe empirical study aims to examine the impact of board diversity with respect to gender and nationality on firm performance in an emerging economy. This research further splits the sample into family and non-family domains and investigates the diversity–performance nexus in isolation.Design/methodology/approachThe sample consists of 183 listed companies in Bangladesh over the period 2007 to 2017. This study employed the generalised method of moments (GMM) technique to address the possible endogeneity issue in the governance–performance connection. To underscore the strength of diversity, three distinctive assessment measures were used: percentage representation of females and foreign directors, the Blau index and the Shannon index.FindingsThe results for the full sample models reveal that board heterogeneity regarding both female and foreign directors positively and significantly influences firm performance as measured by return on assets (ROA). Further to this, female directors in family-owned businesses have a positive association with profitability, whereas foreign nationals demonstrate a significant positive association with performance in non-family firms. Additionally, at least three women directors are needed to make a positive difference in profitability; however, a sole director with foreign nationality is capable of demonstrating a similar impact on performance.Practical implicationsThe findings are significant for policymakers and organisations that advocate diversity on corporate boards of directors, and the minimum number of diverse board members needs to be considered depending on the identity to bring about a significant change in organisational outcome. Therefore, the findings of this study may be applied to other emerging economies with similar institutional characteristics.Originality/valueThis study reinforces the existing stock of knowledge on the impact of board diversity on the profitability of firms, especially in the context of an emerging economy – Bangladesh. Irrespective of the given backdrop, this study finds that both gender and nationality diversity in the case of Bangladesh is found to have a positive and significant effect on financial performance with respect to all the diversity metrics, i.e. the proportionate number of female and foreign directors on the boards, the Blau index and the Shannon index.
Bridging the digital divide in Africa via universal service funds: an institutional theory perspective
Authors: Arakpogun Emmanuel Ogiemwonyi , Whalley Jason , Wanjiru Roseline , Elsahn Ziad , Kummitha Rama Krishna Reddy 
Published: May 2023

PurposeThe purpose of this paper is to provide evidence-based policy recommendations for improving the implementation of universal service funds (USF) with a view to closing the digital divide in Africa.Design/methodology/approachThe paper adopts a qualitative approach that draws examples from various African countries supported by 25 interviews from key stakeholders with hands-on experience and roles that shape telecommunications policy in Africa and other developing countries.FindingsThe study's findings point out that institutional voids which characterize several African countries inhibit the effectiveness of USF in African countries. The authors identify several institutional and organisational factors and explain how they negatively affect the performance of USF. The authors find that in order to overcome these obstacles, there is a need for a clear redefinition of Universal Access and Service (UAS) policies, restructuring the governance of USF, encouraging cross-sectoral collaborations, and bottom-up initiatives to bridge the digital divide in African countries.Originality/valueThe paper contributes to the underexplored USF literature by shedding light on the role of institutional factors in determining the success of USF. The paper thus complements and provides a different perspective on promoting digital inclusion in Africa from the viewpoint of institutional voids, bringing new insights into the existing literature on how to deal with an intractable area of UAS policy and the wider digital divide debate in developing countries.
The evolving field of global mobility: responses to global volatility (2013–2022)
Authors: Ridgway Maranda , Langinier Hélène 
Published: May 2023

PurposeA decade has passed since Dabicet al. (2015) published a systematic review of the evolution of the expatriate literature from 1970 to 2012. Moreover, the past five years have been turbulent, with many global crises affecting organizational approaches to the global movement of people, particularly expatriate workers. Thus, this article seeks to understand how global mobility has continued to evolve during such turbulence and propose avenues for future research.Design/methodology/approachIn this study, the authors undertook a constructive replication (Köhler and Cortina, 2021) of the systematic literature review conducted by Dabicet al. (2015), informed by guidelines offered by Donthuet al. (2021) for the period 2013 to 2022. The authors conducted a performance analysis of 1,517 academic articles about expatriates and broader globally mobile workers. Additionally, the authors analyzed all expatriate-related special issues published in the past decade and provide a narrative review of seminal works from the past five years.FindingsThe expatriation field has grown exponentially; greater attention has been paid to contextualizing research, particularly concerning emerging markets, although the field remains Western-dominant. This analysis stresses the increasingly strategic nature of expatriation at a time when global staffing has become dramatically challenging. Thus, this review highlights the need for more interdisciplinarity at different levels between expatriation and the field of strategy. The authors argue the need for a multifaceted understanding of the expatriation experience.Originality/valueThe authors offer a constructive replication of a bibliometric literature review extended by a narrative analysis to complement a critical perspective on a large set of bibliographic data on the broad subject of expatriation. This addition offers an integrated view of the different themes identified by the bibliometric analysis and paves the way for future replication studies to examine how fields evolve.
Leader–member exchange and innovative work behavior: a 2-1-1 model
Authors: Dar Nasib , Kundi Yasir Mansoor , Soomro Shuaib Ahmed 
Published: May 2023

PurposeThis study aims to examine the link between leader–member exchange (LMX) and employee innovative work behavior (IWB) by using employee job crafting as a mediator.Design/methodology/approachThe study uses multilevel, multisource and multiwave data collected from 284 employees working in the banking sector of Pakistan.FindingsThe study findings suggest a significant positive relationship between (i) LMX and job crafting dimensions and (ii) job crafting dimensions and employee IWB. Job crafting dimensions mediated the impact of LMX on IWB, except for relational crafting, which was not significant. Multilevel analysis demonstrated significant individual-level job crafting and IWB.Originality/valueThis study undertakes a multilevel mediational analysis to examine the relationship between LMX and IWB, which is rarely applied in the existing literature. Moreover, this study contributes to understanding how LMX influences IWB using the conservation of resources theory.
Algorithms for better decision-making: a qualitative study exploring the landscape of robo-advisors in India
Authors: Nain Indu , Rajan Sruthi 
Published: May 2023

PurposeThis paper explores the current state of Robo-advisory services in India. This paper further highlights the problems experienced by the service providers in disseminating the innovative business model among the Indians.Design/methodology/approachThe study adopts a qualitative approach to investigate the industry experts by conducting semi-structured interviews. The data collected were transcripted and further analyzed using the content analysis technique. Finally, the authors utilized categorization and coding techniques to frame broad study themes.FindingsThe study findings reveal that the three pillars of Robo-advisory are ease and convenience, the time factor and transparency in operations. Robo-advisory services are still at a nascent stage in India. Furthermore, keeping the sentiments of Indians in mind, FinTech companies could combine automated Robo-advisory with a human touch of a wealth manager for optimal advisory services.Research limitations/implicationsSince the present study is qualitative, the authors cannot generalize the study results. Future research can focus on empirically proving the constructs of the study using quantitative methods.Practical implicationsRobo-advisors have a well-established market in developed nations but are still nascent in developing countries like India. The current focus of service providers and regulatory authorities must be to increase awareness among investors by educating the investors and building trust.Originality/valueThe present study is the first to qualitatively synthesize the challenges faced by the FinTech service providers in the Indian market.
Barrier function and ultrastructure characteristics of epidermis in patients with primary cutaneous amyloidosis
Authors: Zhang Yuling , Le Ya , Guo Junyi , Wu Fangfang , Li Qing , Lu Ping 
Published: May 2023

AbstractPrevious studies on primary cutaneous amyloidosis (PCA) have mainly focused on exploring genetic mutation and components of amyloid in patients with PCA. However, studies on skin barrier function in PCA patients are scarce. Here, we detected the skin barrier function in PCA patients and healthy people by using noninvasive techniques and characterized ultrastructural features of PCA lesions compared with healthy people using transmission electron microscopy (TEM). The expression of proteins related to skin barrier function was examined by immunohistochemistry staining. A total of 191 patients with clinically diagnosed PCA and 168 healthy individuals were enrolled in the study. Our analysis revealed that all investigated lesion areas displayed higher transepidermal water loss and pH values, and lower Sebum levels and stratum corneum hydration levels in PCA patients compared with the same site area in healthy individuals. The TEM results showed that the intercellular spaces between the basal cells were enlarged and the number of hemidesmosomes decreased in PCA lesions. Immunohistochemical staining showed that the expression of integrin α6 and E‐cadherin in PCA patients was less than that in healthy controls, while no differences in the expression of loricrin and filaggrin were observed. Our study revealed that individuals with PCA displayed skin barrier dysfunction, which may be related to alterations in epidermal ultrastructure and a decrease in the skin barrier‐related protein E‐cadherin. However, the molecular mechanisms underlying skin barrier dysfunction in PCA remain to be elucidated.
Soil filtration‐sedimentation improves shelled protist recovery in eukaryotic eDNA surveys
Authors: Lentendu Guillaume , Bruni Estelle P. , Ah‐Peng Claudine , Fujinuma Junichi , Kubota Yasuhiro , Lorite Juan , Peñas Julio , Huang Shuyin , Strasberg Dominique , Vittoz Pascal , Mitchell Edward A. D. 
Published: May 2023

AbstractA large part of the soil protist diversity is missed in metabarcoding studies based on 0.25 g of soil environmental DNA (eDNA) and universal primers due to ca. 80% co‐amplification of non‐target plants, animals and fungi. To overcome this problem, enrichment of the substrate used for eDNA extraction is an easily implemented option but its effect has not yet been tested. In this study, we evaluated the effect of a 150 μm mesh size filtration and sedimentation method to improve the recovery of protist eDNA, while reducing the co‐extraction of plant, animal and fungal eDNA, using a set of contrasted forest and alpine soils from La Réunion, Japan, Spain and Switzerland. Total eukaryotic diversity was estimated by V4 18S rRNA metabarcoding and classical amplicon sequence variant calling. A 2‐ to 3‐fold enrichment in shelled protists (Euglyphida, Arcellinida and Chrysophyceae) was observed at the sample level with the proposed method, with, at the same time, a 2‐fold depletion of Fungi and a 3‐fold depletion of Embryophyceae. Protist alpha diversity was slightly lower in filtered samples due to reduced coverage in Variosea and Sarcomonadea, but significant differences were observed in only one region. Beta diversity varied mostly between regions and habitats, which explained the same proportion of variance in bulk soil and filtered samples. The increased resolution in soil protist diversity estimates provided by the filtration‐sedimentation method is a strong argument in favour of including it in the standard protocol for soil protist eDNA metabarcoding studies.
The dual nature of cyberloafing
Authors: Spector Paul E. 
Published: May 2023

AbstractCyberloafing occurs when employees use electronic devices for nonwork activities while at work. It can have both constructive (means of regulating stress) and destructive (form of counterproductive work behavior) impact. For jobs where there is a fixed schedule of work versus break time, defining cyberloafing is clearcut. In other jobs where employees are allowed to self‐regulate their work flows, it can be difficult to distinguish cyberloafing from legitimate breaks.