bluuebunny/crossref_metadata_2025_split huggingface dataset:
Postsynaptic Protein Shank3a Deficiency Synergizes with Alzheimer's Disease Neuropathology to Impair Cognitive Performance in the 3xTg-AD Murine Model
Authors: Landry Olivier , François Arnaud , Oye Mintsa Mi-Mba Méryl-Farelle , Traversy Marie-Therese , Tremblay Cyntia , Emond Vincent , Bennett David A. , Gylys Karen H. , Buxbaum Joseph D. , Calon Frédéric 
Published: May 2023

Synaptic loss is intrinsically linked to Alzheimer's disease (AD) neuropathology and symptoms, but its direct impact on clinical symptoms remains elusive. The postsynaptic protein Shank3 (SH3 and multiple ankyrin repeat domains) is of particular interest, as the loss of a single allele of theSHANK3gene is sufficient to cause profound cognitive symptoms in children. We thus sought to determine whether a SHANK3 deficiency could contribute to the emergence or worsening of AD symptoms and neuropathology. We first found a 30%-50% postmortem loss of SHANK3a associated with cognitive decline in the parietal cortex of individuals with AD. To further probe the role of SHANK3 in AD, we crossed male and female 3xTg-AD mice modelling Aβ and tau pathologies withShank3a-deficient mice (Shank3Δex4-9). We observed synergistic deleterious effects of Shank3a deficiency and AD neuropathology on object recognition memory at 9, 12, and 18 months of age and on anxious behavior at 9 and 12 months of age in hemizygous Shank3Δex4-9-3xTg-AD mice. In addition to the expected 50% loss of Shank3a, levels of other synaptic proteins, such as PSD-95, drebrin, and homer1, remained unchanged in the parietotemporal cortex of hemizygous Shank3Δex4-9animals. However, Shank3a deficiency increased the levels of soluble Aβ42and human tau at 18 months of age compared with 3xTg-AD mice with normal Shank3 expression. The results of this study in human brain samples and in transgenic mice are consistent with the hypothesis that Shank3 deficiency makes a key contribution to cognitive impairment in AD.SIGNIFICANCE STATEMENTAlthough the loss of several synaptic proteins has been described in Alzheimer's disease (AD), it remains unclear whether their reduction contributes to clinical symptoms. The results of this study in human samples show lower levels of SHANK3a in AD brain, correlating with cognitive decline. Data gathered in a novel transgenic mouse suggest that Shank3a deficiency synergizes with AD neuropathology to induce cognitive impairment, consistent with a causal role in AD. Therefore, treatment aiming at preserving Shank3 in the aging brain may be beneficial to prevent AD.
Ovol1/2 loss‐induced epidermal defects elicit skin immune activation and alter global metabolism
Authors: Dragan Morgan , Chen Zeyu , Li Yumei , Le Johnny , Sun Peng , Haensel Daniel , Sureshchandra Suhas , Pham Anh , Lu Eddie , Pham Katherine Thanh , Verlande Amandine , Vu Remy , Gutierrez Guadalupe , Li Wei , Jang Cholsoon , Masri Selma , Dai Xing 
Published: May 2023

AbstractSkin epidermis constitutes the outer permeability barrier that protects the body from dehydration, heat loss, and myriad external assaults. Mechanisms that maintain barrier integrity in constantly challenged adult skin and how epidermal dysregulation shapes the local immune microenvironment and whole‐body metabolism remain poorly understood. Here, we demonstrate that inducible and simultaneous ablation of transcription factor‐encoding Ovol1 and Ovol2 in adult epidermis results in barrier dysregulation through impacting epithelial‐mesenchymal plasticity and inflammatory gene expression. We find that aberrant skin immune activation then ensues, featuring Langerhans cell mobilization and T cell responses, and leading to elevated levels of secreted inflammatory factors in circulation. Finally, we identify failure to gain body weight and accumulate body fat as long‐term consequences of epidermal‐specific Ovol1/2 loss and show that these global metabolic changes along with the skin barrier/immune defects are partially rescued by immunosuppressant dexamethasone. Collectively, our study reveals key regulators of adult barrier maintenance and suggests a causal connection between epidermal dysregulation and whole‐body metabolism that is in part mediated through aberrant immune activation.
O‐GlcNAcylation promotes topoisomerase IIα catalytic activity in breast cancer chemoresistance
Authors: Liu Yangzhi , Yu Kairan , Zhang Keren , Niu Mingshan , Chen Qiushi , Liu Yajie , Wang Lingyan , Zhang Nana , Li Wenli , Zhong Xiaomin , Li Guohui , Wu Sijin , Zhang Jianing , Liu Yubo 
Published: May 2023

AbstractDNA topoisomerase IIα (TOP2A) plays a vital role in replication and cell division by catalytically altering DNA topology. It is a prominent target for anticancer drugs, but clinical efficacy is often compromised due to chemoresistance. In this study, we investigate the role of TOP2A O‐GlcNAcylation in breast cancer cells and patient tumor tissues. Our results demonstrate that elevated TOP2A, especially its O‐GlcNAcylation, promotes breast cancer malignant progression and resistance to adriamycin (Adm). O‐GlcNAcylation at Ser1469 enhances TOP2A chromatin DNA binding and catalytic activity, leading to resistance to Adm in breast cancer cells and xenograft models. Mechanistically, O‐GlcNAcylation‐modulated interactions between TOP2A and cell cycle regulators influence downstream gene expression and contribute to breast cancer drug resistance. These results reveal a previously unrecognized mechanistic role for TOP2A O‐GlcNAcylation in breast cancer chemotherapy resistance and provide support for targeting TOP2A O‐GlcNAcylation in cancer therapy.
The Analysis of Leverage, Return on Assets, and Firm Size on Tax Avoidance
Authors: Paramita Astriyani Sandya , Ardiansah Muhammad Noor , Delyuzar Raissa Arham , Dzulfikar Arif 
Published: May 2023

Purpose : The study aims to analyze the effect of leverage, return on assets, and firm size on tax avoidance in Property and Real Estate Companies listed on the Indonesia Stock Exchange (IDX) for the 2010-2016 period.
Method : The population in this research are real estate companies listed on the Indonesia Stock Exchange. The sample selection process in this research used a purposive sampling method. Testing the effect of leverage, return on assets, and firm size on tax avoidance is done using multiple linear regression analysis models.
Findings : Based on the results of the study, the CETR level is positively and significantly influenced by the level of return on assets and company size. Meanwhile, CETR is negatively and significantly affected by the level of leverage.
Novelty : In this study, the sample is focused on property and real estate companies listed on the Indonesia Stock Exchange based on sharia stocks because related research has not been widely studied, so it is necessary to do more about tax avoidance in sharia stocks.
Keywords : Tax Avoidance; Return on Assets; Leverage; Firm Size
What Factors Determine Banking Profitability In Indonesia During The Covid-19 Pandemic?
Authors: Rohman Abdul , Nurkhin Ahmad 
Published: May 2023

Purpose : The banking industry faced significant challenges during the COVID-19 pandemic. Banking performance is being scrutinized for interested parties to evaluate future business projections. The purpose of this study is to analysis the profitability of Indonesian banks during the COVID-19 pandemic and to investigate what factors influence the profitability.
Method : This research is quantitative research and uses panel data. The research sample is a banking company listed on the Indonesia Stock Exchange with a two-year observation period (2020-2021), that is, during the COVID-19 pandemic. There are 49 banks and unbalanced panel data obtained from 97-unit analysis. Return on Assets (ROA), Return on Equity (ROE), and Net Interest Margin are all used to measure banking profitability (NIM). The documentation method was used to collect data. The data was analyzed using descriptive statistics and multiple regression analysis with random effect model.
Findings : The result indicate that only NPL has a significant negative effect on ROA and ROE, according to the findings. Meanwhile, even though it is negative, CAR has a significant impact on ROA and ROE. The effects of size and liquidity on ROA and ROE were not significant. Similarly, there is no significant evidence of size, liquidity, CAR, or NPL on the Indonesian banking NIM. It can be concluded that only NPL and CAR have a significant impact on Indonesian banking profitability.
Novelty : The novelty in this paper is an analysis of banking profitability in Indonesia during the COVID-19 pandemic (2020-2021) and a study of the factors that influence it. Unbalanced data panel regression with random effect model was used to analyze the data.
Keywords : Profitability; Return on Assets; Return on Equity; Net Interest Margin; Non-Performing Loan
Mesenchymal stem cell secretome alters gene expression and upregulates motility of human endometrial stromal cells
Authors: Zhao Qingshi , Larios Karla , Naaldijk Yahaira , Sherman Lauren S , Chemerinski Anat , Okereke Kennisha , Rameshwar Pranela , Lemenze Alexander , Douglas Nataki C , Morelli Sara S 
Published: May 2023

In brief
Endometrial stromal cell motility is fundamental to regeneration and repair of this tissue and crucial for successful reproduction. This paper shows a role for the mesenchymal stem cell (MSC) secretome in enhancing endometrial stromal cell motility.

Abstract
Cyclic regeneration and repair of the endometrium are crucial for successful reproduction. Mesenchymal stem cells (MSCs) derived from bone marrow (BM-MSC) and umbilical cord (UC-MSC) facilitate tissue repair via their secretome, which contains growth factors and cytokines that promote wound healing. Despite the implication of MSCs in endometrial regeneration and repair, mechanisms remain unclear. This study tested the hypothesis that the BM-MSC and UC-MSC secretomes upregulate human endometrial stromal cell (HESC) proliferation, migration, and invasion and activate pathways to increase HESC motility. BM-MSCs were purchased from ATCC and cultured from the BM aspirate of three healthy female donors. UC-MSCs were cultured from umbilical cords of two healthy male term infants. Using indirect co-culture of MSCs and hTERT-immortalized HESCs via a transwell system, we demonstrated that co-culture of HESCs with BM-MSCs or UC-MSCs from all donors significantly increased HESC migration and invasion, whereas effects on HESC proliferation varied among BM-MSC and UC-MSC donors. Analysis of gene expression by mRNA sequencing and RT-qPCR showed that expression of CCL2 and HGF was upregulated in HESCs that had been cocultured with BM-MSCs or UC-MSCs. Validation studies revealed that exposure to recombinant CCL2 for 48 h significantly increased HESC migration and invasion. Increased HESC motility by the BM-MSC and UC-MSC secretome appears to be mediated in part by upregulated HESC CCL2 expression. Our data support the potential for leveraging MSC secretome as a novel cell-free therapy to treat disorders of endometrial regeneration.
Paid Family Caregiving for Children With Medical Complexity
Authors: Brittan Mark S. , Chavez Catia , Blakely Christy , Holliman Brooke Dorsey , Zuk Jeannie 
Published: May 2023

OBJECTIVES
We evaluated Colorado’s paid family caregiver certified nursing assistant (CNA) program by assessing stakeholders’ perceptions of the model’s strengths and potential areas for improvement.

METHODS
A professional bilingual research assistant conducted key informant interviews of English- and Spanish-speaking certified nursing assistant (CNA) family caregivers (FCs), primary care providers, and pediatric home health administrators of children with medical complexity in the family caregiver CNA program. Interview questions focused on the program’s benefits, drawbacks, and implications for the child and caregiver’s quality of life. Transcripts were coded and analyzed, and themes summarizing program benefits and disadvantages were identified.

RESULTS
Semistructured interviews were completed by phone with 25 FCs, 10 home health administrators, and 10 primary care providers between September 2020 and June 2021. Overall, the program was highly valued and uniformly recommended for prospective families. Perceived benefits included: (1) fulfilling the desire to be a good parent, (2) providing stable and high-quality home health care, (3) benefitting the child’s health and wellbeing, and (4) enhancing family financial stability. Perceived drawbacks included: (1) FCs experiencing mental and physical health burdens, (2) difficult access for some community members, (3) extraneous training requirements, and (4) low program visibility.

CONCLUSIONS
Given the perceived benefits of the family CNA program, the model may be considered for future dissemination to other communities. However, additional research and program improvements are needed to help make this a more equitable and sustainable home health care model for children with medical complexity.
ФАЗОВІ РІВНОВАГИ В СИСТЕМІ La2O3-Lu2O3-Er2O3 ЗА 1500 і 1600 °
Authors: Чудінович Ольга В. , Широков Олександр В. , Самелюк Анатолій В. 
Published: May 2023

Фазові співвідношення в потрійній системі La2O3-Lu2O3-Er2O3 за 1500 і 1600 °С вивчали в усьому діапазоні концентрацій методами рентгенівської дифракції (РФА) і скануючої електронної мікроскопії (СЕМ). Як вихідні речовини використовували оксиди La, Lu та Er (99.99 %). Зразки готували з кроком концентрування 1–5 мол. %. Оксиди розчиняли в HNO3 (1 : 1) з наступним випарюванням розчинів і розкладанням нітратів за 800 °C протягом 2 годин. Зразки піддавали термічній обробці за 1500 °C (протягом 70 годин) та 1600 °C (протягом 10 годин) на повітрі. Фазовий склад досліджуваних зразків вивчали за допомогою рентгенофазового (РФА, ДРОН-3), мікроструктурного та електронно-мікрозондового (Superprobe-733, JEOL, Японія, Пало-Альто, Каліфорнія) аналізів. У системі виявлено тверді розчини на основі різних поліморфних форм вихідних оксидів і впорядкованих фаз LaLuO3 (LaErO3). Нових фаз у системі не виявлено. Ізотермічні перерізи фазової діаграми стану La2O3-Lu2O3-Er2O3 при 1500 і 1600 °С характеризуються наявністю трьох однофазних (A-La2O3, R, C-Lu2O3 (Er2O3)) і двох двофазних (C+R, A+R) областей. Система утворює безперервні серії твердих розчинів на основі кубічної модифікації C-Lu2O3(Er2O3) та впорядкованої фази типу перовскіту (R-фаза). Визначено межі розчинності та побудовано концентраційні залежності періодів і параметрів ґратки елементарної комірки фаз, що утворюються в системі. Діапазон гомогенності твердих розчинів на основі R-фази простягається від 46 до 54 мол. % La2O3 за 1500 °C і від ~48 до 54 мол. % La2O3 за 1600 °C. Оксиди лютецію та ербію утворюють неперервний ряд твердих розчинів оксидів C-REE.
ВПЛИВ ПАРАМЕТРІВ ЕКСТРАГУВАННЯ НА ВЛАСТИВОСТІ СУБКРИТИЧНИХ ВОДНИХ ЕКСТРАКТІВ СОЄВОГО ШРОТУ
Authors: Сукманов Валерій О. , Ковальчук Олена В. 
Published: May 2023

Робота присвячена дослідженню процесу екстрагування субкритичною водою соєвого шроту та впливу па-раметрів екстрагування на властивості рідких та сухих екстрактів. Метою дослідження є встановлення впли-ву параметрів процесу субкритичного водного екстрагування (температура: 120–160 °С, тривалість екстра-гування: 5…15 хв, гідромодуль: 1 : 15…25) на властивості рідких та сухих екстрактів соєвого шроту та їх опти-мальних значень. Характер залежності показників екстрактів від параметрів процесу екстрагування встано-влено емпірично. Для визначення коефіцієнтів інтерполяційної моделі було заплановано проведення дроб-нофакторного експерименту 33–1 за ортогональним композиційним планом 2-го порядку. Рідкі екстракти отримано на лабораторній установці на базі реактора високого тиску. Сухі екстракти отримували методом випарювання. Для рідких екстрактів визначали pH та вміст сухих речовин. Для сухих екстрактів визначали вміст мінеральних речовин, залишкової води, білку та ізофлавонів. Аналіз екстрактів виконували за інструментальними методиками відповідно до вимог Державної фармакопеї України, із використанням сучасного обладнання. Встановлено коефіцієнти квадратичних інтерполяційних моделей, аналіз яких дозволив встановити оптимальні параметри екстрагування. Встановлено, що на досліджуваних діапазонах тривалості та температури екстрагування вміст сухих речовин у рідких екстрактах та вміст білка у сухих екстрактах мають максимуми, величина яких монотонно зростає зі збільшенням частки води в екст-ракційній суміші. Вміст мінеральних речовин мав максимум лише за температурою, а ізофлавонів – за трива-лістю екстрагування. Отримані результати можуть бути використані при удосконаленні технології отриман-ня соєвих білкових концентратів та ізолятів із застосуванням методу субкритичного водного екстрагування.
Mujeres del Sur en el quehacer teatral costarricense (1970-1990)
Authors: Gutiérrez Rojas Marisol , Barrionuevo Claudia 
Published: May 2023

Esta investigación identifica y sistematiza los aportes de las chilenas Carmen Bunster, Sara Astica y Bélgica Castro y las argentinas Haydée de Lev, Gladys Catania y Ana María Barrionuevo, en tres décadas medulares para las artes escénicas de Costa Rica: 1970-1990. La actuación, la enseñanza del teatro y la divulgación de la tarea teatral, así como el trabajo en cine, radio o actividades gremiales, marcan el trabajo de estas mujeres quienes, por migración voluntaria o por exilio político, llegaron al país. La revisión del contexto cultural y teatral de esos treinta años del siglo pasado evidencian un camino que va desde la profesionalización del teatro en la década de 1970 hasta el teatro comercial y ligero de la década de 1990, pasando por las interrogantes de un teatro de 1980 en busca de su identidad.
cuestión masónica en la izquierda italiana
Authors: Novarino Marco 
Published: May 2023

La moción antimasónica, votada en el congreso del Partido Socialista Italiano (PSI) de 1914, zanjó una polémica en el movimiento socialista desde principios del siglo XX y que había creado una cesura en las relaciones entre las dos organizaciones. Cuando, en 1919, el PSI decidió adherirse a la nueva Internacional comunista, la polémica antimasónica formó parte de los debates en los congresos de antes de la muerte de Lenin. Sobre todo, cuando resultó claro que muchos socialistas-masones se habían adherido al Partido comunista francés, la Internacional, principalmente por voluntad de Trotsky, que adoptó posiciones muy rígidas sobre la cuestión.
Inhabilitación absoluta y perpetua de Vicent Sampedro Ramo
Authors: Vicente Sánchez Hector 
Published: May 2023

Reseña del libro Inhabilitación absoluta y perpetua. La represión franquista contra los masones de Castelló de Vicent Sampedro Ramo. Castelló de la Plana: Universitat Jaume I, 2020. 374 páginas. ISBN: 978-84-17900-86-1.
Investigating gaming structural features associated with gaming disorder and proposing a revised taxonomical model: A scoping review
Authors: Saini Nirav , Hodgins David Carson 
Published: May 2023

AbstractBackground and aimsGaming disorder (GD) is a mental health concern that has been heavily contested by experts. This scoping review synthesizes the literature to identify the structural features of video game design that can contribute to GD. Furthermore, a taxonomy of the structural features implicated with GD is proposed, revised from earlier work.MethodsSeven databases, in addition to Google Scholar, were searched. Peer-reviewed studies were included if they assessed a link between gaming structural characteristics and GD or a proxy. The final pool included 105 articles.ResultsAvatar creation and customizability, multiplayer characteristics, and reward and punishment features were highly represented in the literature. There was no evidence for three categories in the original taxonomy: support network features, sexual content, and explicit language. Furthermore, structural feature sub-categories emerged that were absent from the previous taxonomy, such as general socialization features, type of virtual world, and in-game currency. Manipulation and control features and presentation features were less represented than social features, narrative and identity features, and reward and punishment features. The reviewers propose two broad classes of addictive gaming structural features: ‘features enhancing in-game immersion and realism’ and ‘gambling-like features’.Discussion and conclusionsNumerous studies found a relationship between social, narrative and identity, and reward and punishment structural characteristics with GD. Two broad classes of gaming structural features were associated with addiction. The first, ‘features enhancing in-game immersion and realism,’ including social gameplay, avatar creation, storytelling, and graphics/sound. The second, ‘gambling-like features,’ included different mechanisms of rewards-and-punishment.
The SsPmp phase in regional wave propagation
Authors: Langston Charles A. 
Published: May 2023

Abstract
Regional broadband waveforms of deep- and intermediate-depth earthquakes written at College, Alaska, and Matsushiro, Japan, show large SsPmp phases that may be the largest phase seen on the seismogram. SsPmp is created when the direct, upgoing SV wave converts to a P wave at the free surface and subsequently becomes trapped in the crust because of postcritical P-wave reflection at the Moho. SsPmp may arrive between the P- and S-wave phases or it may arrive after S, depending on source depth and distance. Thus, it can be used as an additional constraint on source depth and location. It is important to recognize the existence of this phase since it is easily confused with the S-wave arrival, resulting in erroneous S-wave arrival time picks, or it may be interpreted as a split shear wave, incorrectly implying shear-wave anisotropy in the medium. Such a wave propagation effect will also be important for a crustal source for structures that contain low-velocity layers near the surface.
Fish Image Classification Using Adaptive Learning Rate In Transfer Learning Method
Authors: Suhana Rizka , Mahmudy Wayan Firdaus , Budi Agung Setia 
Published: May 2023

The existence of fish species diversity in coastal ecosystems which include mangrove forests, seagrass beds and coral reefs is one of the benchmarks in determining health in coastal ecosystems. It is certain that we must maintain, preserve and care for so that conservation efforts need to be carried out in water areas. Many experts at the Indonesian Fisheries and Marine Research and Development Agency often classify fish images manually, of course it will take a long time, therefore with today's developments they can use the latest technology. One of the reliable techniques in terms of image classification is Convolutional Neural Network (CNN). As time goes by, of course, many people want fast learning and solving new problems faster and better, so transfer learning appears, which adopts part of CNN, the name is modified convolution layer. Observing the needs of experts in the field of marine conservation, the researchers decided to solve this problem by using transfer learning modifications. The transfer learning used is an architectural model from the pre-trained Mobilenet V2, which is known for its light computing process and can be applied to our gadgets and other embedded tools. The research image data used is 49.281 data of various sizes and there are 18 types of fish, in the pre-processing data there is a resize of the image to a size of 224x224 pixels. testing with the modified transfer learning architectural model obtained an accuracy score of 99.54%, this model is quite reliable in classifying fish images.