bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ultrasound Guidance Pulsed Radiofrequency Ablation of the Medial Antebrachial Cutaneous Nerve for Palliation of Chronic Pain after Burn Injury: A Case Report
Authors: Yayik Ahmet Murat , Narayanan Madan , Karapinar Yunus Emre , Simsek Nagihan , Aydin Muhammed Enes , Ahiskalioglu Ali 
Published: January 2023

AbstractChronic burn pain persists for 6 months or longer after the wound has healed, affecting the patient’s quality of life and daily activities. Pharmacological treatments are essential in the treatment of chronic pain after burns, but interventional methods come to the fore in cases where there is no response to pharmacological treatments. Radiofrequency ablation is known as a safe, effective, and minimally invasive treatment for patients with intractable chronic pain. Various pain syndromes can be successfully treated with radiofrequency ablation however, there is no publication of chronic pain management associated with burn injury. Here, we first describe the successful management of chronic burn pain using radiofrequency ablation of the medial antebrachial cutaneous nerve.
Cauchy mutation boosted Harris hawk algorithm: optimal performance design and engineering applications
Authors: Shan Weifeng , He Xinxin , Liu Haijun , Heidari Ali Asghar , Wang Maofa , Cai Zhennao , Chen Huiling 
Published: January 2023

AbstractHarris hawks optimization (HHO) has been accepted as one of the well-established swarm-based methods in the community of optimization and machine learning that primarily works based on multiple dynamic features and various exploratory and exploitative traits. Compared with other optimization algorithms, it has been observed that HHO can obtain high-quality solutions for continuous and constrained complex and real-world problems. While there is a wide variety of strategies in the HHO for dealing with diverse situations, there are chances for sluggish performance, where the convergence rate can gradually slow with time, and the HHO may stay stuck in the current relatively better place and may be unable to explore other better areas. To mitigate this concern, this paper combines the Cauchy mutation mechanism into the HHO algorithm named CMHHO. This idea can boost performance and provide a promising optimizer for solving complex optimization problems. The Cauchy mutation mechanism can speed up the convergence of the solution and help HHO explore more promising regions compared to its basic release. On 30 IEEE CEC2017 benchmark functions, the study compared the proposed CMHHO with various conventional and advanced metaheuristics to validate its performance and quality of solutions. It has been found through experiments that the overall optimization performance of CMHHO is far superior to all competitors. The CMHHO method is applied to four engineering challenges to investigate the capabilities of the proposed algorithm in solving real-world problems, and experimental results show that the suggested algorithm is more successful than existing algorithms.
A novel feed rate scheduling method with acc-jerk-continuity and round-off error elimination for non-uniform rational B-spline interpolation
Authors: Hu Yifei , Jiang Xin , Huo Guanying , Su Cheng , Zhou Shiwei , Wang Bolun , Li Hexiong , Zheng Zhiming 
Published: January 2023

Abstract
Feed rate scheduling is a critical step in computer numerical control machining, as it has a close relationship with machining time and surface quality. It has now become a hot issue in both industry and academia. In this article, we present a novel and complete S-shape-based feed rate scheduling method for three-axis non-uniform rational B-spline (NURBS) tool paths, which can reduce high chord errors and round-off errors, and generate continuous velocity, acceleration, and jerk profile. The proposed feed rate scheduling method consists of three modules: a bidirectional scanning module, a velocity scheduling module, and a round-off error elimination module. The bidirectional scanning module aims to guarantee the continuity of the feed rate at the junctions between successive NURBS blocks, where the chord error, tangential acceleration, and tangential jerk limitations are considered. After the NURBS blocks have been classified into two cases by the previous module, the velocity scheduling module first calculates the actual maximum feed rate. It then generates the feed rate profiles of all NURBS blocks according to the proposed velocity profile. Later, the round-off error elimination module is applied to adjust the actual maximum feed rate so that the total interpolation time becomes an integer multiple of the interpolation period, which leads to the elimination of round-off errors. Finally, benchmarks are conducted to verify the applicability of the proposed method. Compared with the traditional method, the proposed method can save the interpolation time by $4.67$ to $14.26\% $.
People, places, and time: a large-scale, longitudinal study of transformed avatars and environmental context in group interaction in the metaverse
Authors: Han Eugy , Miller Mark R , DeVeaux Cyan , Jun Hanseul , Nowak Kristine L , Hancock Jeffrey T , Ram Nilam , Bailenson Jeremy N 
Published: January 2023

Abstract
As the metaverse expands, understanding how people use virtual reality to learn and connect is increasingly important. We used the Transformed Social Interaction paradigm (Bailenson et al., 2004) to examine different avatar identities and environments over time. In Study 1 (n = 81), entitativity, presence, enjoyment, and realism increased over 8 weeks. Avatars that resembled participants increased synchrony, similarities in moment-to-moment nonverbal behaviors between participants. Moreover, self-avatars increased self-presence and realism, but decreased enjoyment, compared to uniform avatars. In Study 2 (n = 137), participants cycled through 192 unique virtual environments. As visible space increased, so did nonverbal synchrony, perceived restorativeness, entitativity, pleasure, arousal, self- and spatial presence, enjoyment, and realism. Outdoor environments increased perceived restorativeness and enjoyment more than indoor environments. Self-presence and realism increased over time in both studies. We discuss implications of avatar appearance and environmental context on social behavior in classroom contexts over time.
Potential Alternatives to Spinosad as the Killing Agent Mixed With Two Attractant Products in Attract-and-Kill Formulations Used to Manage the Spotted-Wing Drosophila, Drosophila suzukii (Diptera: Drosophilidae)
Authors: Rhodes Elena M , Babu Arun , Sial Ashfaq A , Liburd Oscar E 
Published: January 2023

Abstract
Spotted-wing drosophila, Drosophila suzukii (Matsumura) (Diptera: Drosophilidae), is a key pest of many berry and fruit crops worldwide. The primary method of controlling this pest is the application of insecticides. Attract-and-kill is a management tactic that may reduce the number of insecticide applications needed to manage D. suzukii. ACTTRA SWD OR1 and ACTTRA SWD TD, developed by ISCA Technologies Inc., combine D. suzukii attractants with a gel matrix. Growers add an insecticide as a killing agent. The only USDA National Organic Program approved organic insecticide that has been shown to be effective as a killing agent is spinosad. This study aimed to determine the efficacy of other USDA National Organic Program approved organic insecticides, including Grandevo 30 WDG (Chromobacterium subtsugae strain PRAA4-1 30%), MBI-203 SC2 (C. subtsugae strain PRAA4-1 98%), Venerate XC (Burkholderia spp. Strain A396 94.45%), MBI-306 SC1 (B. rinojensis Strain A396 94.45%), Azera (azadirachtin 1.2% + pyrethrins 1.4%), and PyGanic (pyrethrins 1.4%), when used as the killing agent with the two ACTTRA SWD products. Lab and cage bioassays were conducted. Entrust (spinosad 22.5%) and PyGanic were the only compounds that showed some efficacy when used with ACTTRA SWD OR1 and ACTTRA SWD TD.
Spatial Relevance: Teaching History to Medical Students at a Medical Museum in Hong Kong
Authors: Wu Harry Yi-Jui , Wong Samson Ki Sum 
Published: January 2023

Abstract
This article examines the pedagogical significance of history workshops as part of the mandatory medical curriculum in Hong Kong. At the University of Hong Kong, year one medical students must take a three-hour long history workshop at the Hong Kong Museum of Medical Sciences. We argue that by immersing experiential museum learning into the official medical curriculum, students can grow interest in Hong Kong’s local medical history and discover its spatial relevance to their future practice. Moreover, students are equipped with analytical skills to tackle important agendas, such as historical contingency, multicausality of diseases, and perspectivism in dealing with conflicting narratives. However, we also notice that the way histories are curated in the museum and through the heritage trail could potentially constrain students to develop a limited historiography. The museum exhibitions and the trail walk mostly curated by medical professionals emphasize too much of the comparison of the bubonic plague and SARS that took place in 1894 and 2003. Students might assume the linear progression of medical sciences and the oversimplified dichotomy between traditional and modern medicine. In addition, disproportionate narratives of infectious and non-infectious disease in Hong Kong might result in oversight of the chronicity of general ill health conditions that have long been suffered by local people. Workshop conveners, therefore, need to constantly modify discussion questions to balance demands between the advancement of contemporary medicine emphasized in medical education and the critical thinking process offered by history.
Exploring the World’s First Successful Truth Commission: Argentina’s CONADEP and the Role of Victims in Truth-Seeking
Authors: Vegh Weis Valeria 
Published: January 2023

AbstractThis article will present the case of Argentina and the conditions, struggles and social actors that made the establishment of the world’s first successful truth commission possible after the most recent dictatorship, in power between 1976 and 1983. This study is aimed at not only acknowledging the work of civil society organizations, who pressure powerholders to be responsive to victims’ concerns, but to argue that victims’ organizations were the ones who took a leading role in the truth commissions/achieving justice or human rights. The article will also show that victims’ organizations have worked to reach their goals by engaging with the state from a proactive and empowered position that pushed the process forward over government resistance. Through this in-depth case study, the article aims to transform the question from what shall be done in terms of truth commissions to who shall do it. The assumption is that the leading role of victims’ organizations in engaging with the state through participatory democracy can foster truth-seeking mechanisms beyond the limits of realpolitik.
Investment Law in the Twenty-First Century: Things Will Have to Change in Order to Remain the Same
Authors: van Aaken Anne 
Published: January 2023

ABSTRACT
The future of investment law has in store fundamental shifts, not incremental changes, in three substantive issue areas, which pose immense challenges to the system as it currently stands, namely, climate change, national security, and investor obligations. This article describes those challenges and argues that for these shifts to be accommodated, abolition is not desirable, but reform is necessary and urgent. It suggests procedural ways forward.
Trade Agreements and Sustainability: Exploring the Potential of Global Value Chain (GVC) Obligations
Authors: Harrison James 
Published: January 2023

ABSTRACT
This article investigates the potential of global value chain (GVC)-orientated sustainability provisions in regional and bilateral trade agreements (FTAs). Such provisions impose social and environmental obligations directly onto GVCs, as opposed to creating obligations for governments. The theoretical potential of GVC provisions is examined, and the concepts of effectiveness and legitimacy are introduced as values by which to assess them. Four recent sets of provisions are then scrutinized. These are (i) palm oil sustainability standards from the Indonesia–European Free Trade Association (EFTA) Comprehensive Economic Partnerhsip Agreement (CEPA) FTA, (ii) hen welfare standards in the European Union–Mercosur Association Agreement, (iii) a stipulation of a minimum average wage for the automobile industry in the US–Mexico–Canada Agreement (USMCA), and (iv) enforcement of collective bargaining and freedom of association directly against factories, also in the USMCA. All of these provisions are found to have significant deficiencies. At the same time, it is argued that three different governance models underpin them, namely (i) third-party certification schemes, (ii) domestic regulations of one of the parties, and (iii) bespoke arrangements created for the FTA in question. The article therefore considers the potential and drawbacks of each governance model in terms of their effectiveness and legitimacy, as well as alternative and complementary commitments including unilateral measures and subject-specific trade agreements.
Novel Microsatellite Markers for Osmia lignaria (Hymenoptera: Megachilidae): A North American Pollinator of Agricultural Crops and Wildland Plants
Authors: Koch Jonathan Berenguer Uhuad , Branstetter Michael G , Cox-Foster Diana L , Knoblett Joyce , Lindsay Thuy-Tien Thai , Pitts-Singer Theresa L , Rohde Ashley T , Strange James P , Tobin Kerrigan B 
Published: January 2023

Abstract
Comprehensive decisions on the management of commercially produced bees, depend largely on associated knowledge of genetic diversity. In this study, we present novel microsatellite markers to support the breeding, management, and conservation of the blue orchard bee, Osmia lignaria Say (Hymenoptera: Megachilidae). Native to North America, O. lignaria has been trapped from wildlands and propagated on-crop and used to pollinate certain fruit, nut, and berry crops. Harnessing the O. lignaria genome assembly, we identified 59,632 candidate microsatellite loci in silico, of which 22 were tested using molecular techniques. Of the 22 loci, 12 loci were in Hardy-Weinberg equilibrium (HWE), demonstrated no linkage disequilibrium (LD), and achieved low genotyping error in two Intermountain North American wild populations in Idaho and Utah, USA. We found no difference in population genetic diversity between the two populations, but there was evidence for low but significant population differentiation. Also, to determine if these markers amplify in other Osmia, we assessed 23 species across the clades apicata, bicornis, emarginata, and ribifloris. Nine loci amplified in three species/subspecies of apicata, 22 loci amplified in 11 species/subspecies of bicornis, 11 loci amplified in seven species/subspecies of emarginata, and 22 loci amplified in two species/subspecies of ribifloris. Further testing is necessary to determine the capacity of these microsatellite loci to characterize genetic diversity and structure under the assumption of HWE and LD for species beyond O. lignaria. These markers will inform the conservation and commercial use of trapped and managed O. lignaria and other Osmia species for both agricultural and nonagricultural systems.
Appearances are deceptive: a cryptic lineage within the assumed distributional boundaries ofCtenomys talarum(Rodentia, Ctenomyidae)
Authors: Austrich Ailin , Tomasco Ivanna Haydée , Mapelli Fernando Javier , Kittlein Marcelo Javier , Cutrera Ana Paula , Mora Matías Sebastián 
Published: January 2023

AbstractThe coastal dunes of the southeast of Buenos Aires province, Argentina, present two different described species of tuco-tucos: Ctenomys talarum and C. australis. Formerly, C. talarum was subdivided into three subspecies (C. t. talarum, C. t. recessus, and C. t. occidentalis), mainly based on its geographic distribution and phenotypic variation in characters of external morphology (e.g., body size and pelage color). This study assesses the phylogenetic relationships of C. talarum, focusing on the populations at the western end of its coastal distribution (localities of Pehuen-Có and Sauce Grande), which have been previously identified as highly genetically divergent. In this regard, populations distributed throughout the range of the species were sampled. Complete DNA sequences of the mitochondrial cytochrome b gene (1,140 bp), partial sequences of the mitochondrial D-loop region (426 bp), and partial sequences of the nuclear DNA intron 8 of the β-fibrinogen (about 870 bp) gene were used for the analyses. Phylogenetic inferences based on mitochondrial and nuclear markers were performed separately or combined to obtain a species tree. Populations distributed at the western end of the coastal dunes (between Pehuen-Có and Sauce Grande), previously assumed as C. talarum, were found to belong to an independent lineage relative to the other populations from the Pampas region. The average genetic distance between these two lineages is within the order of the genetic distances observed between different species of the genus. Also, our results show that this lineage of Ctenomys presents a high affinity with the magellanicus group, which is distributed further south, in Patagonia. In conclusion, tuco-tuco populations occurring in the coastal expanse between these two localities should be considered a possible distinct cryptic species, highly differentiated from C. talarum.
Population Genetic Structure ofPhlebotomus sergenti(Diptera: Psychodidae) Collected in Four Regions of Morocco Based on the Analysis ofCyt bandEF-1αGenes
Authors: El Kacem Sofia , Ait Kbaich Mouad , Mhaidi Idris , Daoui Othmane , Bennani Houda , Dvořák Vít , Lemrani Meryem 
Published: January 2023

AbstractPhlebotomus (Ph.) sergenti is the main vector of Leishmania (L.) tropica (Trypanosomatida: Trypanosomatidae), the causative agent of anthroponotic cutaneous leishmaniasis in Morocco. This species has an extended geographical distribution, wider than that of the parasite. The main objective of our study was to analyze the genetic diversity of Ph. sergenti collected in four foci in Morocco: Taza, Foum Jemâa, El Hanchane, and Ouarzazate. We studied a set of diversity and population structure indices by sequencing two markers; nuclear EF-1α and mitochondrial Cyt b from 175 individual sand flies. Our results showed a considerable degree of intraspecific polymorphism with a high number of haplotypes identified in both genes. Many polymorphic sites detected in the Cyt b sequences (SCyt b = 45) indicate that it is the most polymorphic marker showing a distinct distribution of haplotypes according to their geographical origin, whereas the EF-1α marker showed no geographical isolation. Analysis by Tajima’s D and Fu’s Fs tests revealed a possible recent expansion of the populations, especially with the EF-1α marker, showing significant values in Taza and Ouarzazate sequences. The present study revealed significant genetic diversity within Ph. sergenti populations in Morocco. The results warrant further research using a combination of more than two markers including mitochondrial and non-mitochondrial markers, which may provide more information to clarify the genetic status of Ph. sergenti.
A polygenic two-hit hypothesis for prostate cancer
Authors: Houlahan Kathleen E , Livingstone Julie , Fox Natalie S , Kurganovs Natalie , Zhu Helen , Sietsma Penington Jocelyn , Jung Chol-Hee , Yamaguchi Takafumi N , Heisler Lawrence E , Jovelin Richard , Costello Anthony J , Pope Bernard J , Kishan Amar U , Corcoran Niall M , Bristow Robert G , Waszak Sebastian M , Weischenfeldt Joachim , He Housheng H , Hung Rayjean J , Hovens Christopher M , Boutros Paul C 
Published: January 2023

AbstractProstate cancer is one of the most heritable cancers. Hundreds of germline polymorphisms have been linked to prostate cancer diagnosis and prognosis. Polygenic risk scores can predict genetic risk of a prostate cancer diagnosis. Although these scores inform the probability of developing a tumor, it remains unknown how germline risk influences the tumor molecular evolution. We cultivated a cohort of 1250 localized European-descent patients with germline and somatic DNA profiling. Men of European descent with higher genetic risk were diagnosed earlier and had less genomic instability and fewer driver genes mutated. Higher genetic risk was associated with better outcome. These data imply a polygenic “two-hit” model where germline risk reduces the number of somatic alterations required for tumorigenesis. These findings support further clinical studies of polygenic risk scores as inexpensive and minimally invasive adjuncts to standard risk stratification. Further studies are required to interrogate generalizability to more ancestrally and clinically diverse populations.
Vascular injury is associated with repetitive head impacts and tau pathology in chronic traumatic encephalopathy
Authors: Kirsch Daniel , Shah Arsal , Dixon Erin , Kelley Hunter , Cherry Jonathan D , Xia Weiming , Daley Sarah , Aytan Nurgul , Cormier Kerry , Kubilus Carol , Mathias Rebecca , Alvarez Victor E , Huber Bertrand R , McKee Ann C , Stein Thor D 
Published: January 2023

Abstract
Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease linked to repetitive head impacts (RHI) and characterized by perivascular hyperphosphorylated tau (p-tau) deposits. The role of vascular injury, blood-brain barrier leakage, and neuroinflammation in CTE pathogenesis is not well understood. We performed quantitative immunoassays for intercellular adhesion molecule 1 (ICAM1), vascular cellular adhesion molecule 1 (VCAM1), and C-reactive protein (CRP) within the postmortem dorsolateral frontal cortex of participants with and without a history of RHI and CTE (n = 156), and tested for associations with RHI, microgliosis, and tau pathology measures. Levels of vascular injury-associated markers ICAM1, VCAM1, and CRP were increased in CTE compared to RHI-exposed and -naïve controls. ICAM1 and CRP increased with RHI exposure duration (p &lt; 0.01) and were associated with increased microglial density (p &lt; 0.001) and tau pathology (AT8, p-tau396, p-tau202; p &lt; 0.05). Histologically, there was significantly increased ICAM1 staining of the microvasculature, extracellular space, and astrocytes at the sulcal depths in high stage CTE compared to both low stage CTE and controls. Multifocal perivascular immunoreactivity for serum albumin was present in all RHI-exposed individuals. These findings demonstrate that vascular injury markers are associated with RHI exposure, duration, and microgliosis, are elevated in CTE, and increase with disease severity.