bluuebunny/crossref_metadata_2025_split huggingface dataset:
Early Family Intervention for Youth at Risk for Bipolar Disorder: Psychosocial
and Neural Mediators of Outcome
Authors: Miklowitz David J. , Weintraub Marc J. , Walshaw Patricia D. , Schneck Christopher D. , Chang Kiki D. , Merranko John , Garrett Amy S. , Singh Manpreet K. 
Published: January 2023

Background:
The impairing neurodevelopmental course of bipolar disorder (BD) suggests the importance of early intervention for youth in the beginning phases of the illness.

Objective:
We report the results of a 3-site randomized trial of family-focused therapy for youth
at high-risk (FFT-HR) for BD, and explore psychosocial and neuroimaging variables as
mediators of treatment effects.

Methods:
High-risk youth (<18 years) with major depressive disorder or other specified BD,
active mood symptoms, and a family history of BD were randomly assigned to 4 months of FFT-
HR (psychoeducation, communication and problem-solving skills training) or 4 months of
enhanced care psychoeducation. Adjunctive pharmacotherapy was provided by study
psychiatrists. Neuroimaging scans were conducted before and after psychosocial treatments in
eligible participants. Independent evaluators interviewed participants every 4-6 months over 1-4
years regarding symptomatic outcomes.

Results:
Among 127 youth (mean 13.2+2.6 years) over a median of 98 weeks, FFT-HR was
associated with longer intervals prior to new mood episodes and lower levels of suicidal ideation
than enhanced care. Reductions in perceived family conflict mediated the effects of
psychosocial interventions on the course of mood symptoms. Among 34 participants with pre-
/post-treatment fMRI scans, youth in FFT-HR had (a) stronger resting state connectivity between
ventrolateral PFC and anterior default mode network, and (b) increased activity of dorsolateral
and medial PFC in emotion processing and problem-solving tasks, compared to youth in
enhanced care.

Conclusion:
FFT-HR may delay new mood episodes in symptomatic youth with familial liability
to BD. Putative treatment mechanisms include neural adaptations suggestive of improved
emotion regulation.
A Comparative Analytical Review on Machine Learning Methods in Drugtarget
Interactions Prediction
Authors: Nikraftar Zahra , Keyvanpour Mohammad Reza 
Published: January 2023

Background:
Predicting drug-target interactions (DTIs) is an important topic of study in the field of drug discovery and development. Since DTI prediction in vitro studies is very expensive and time-consuming, computational techniques for predicting drug-target interactions have been introduced successfully to solve these problems and have received extensive attention.

Objective:
In this paper, we provided a summary of databases that are useful in DTI prediction and intend to concentrate on machine learning methods as a chemogenomic approach in drug discovery. Unlike previous surveys, we propose a comparative analytical framework based on the evaluation criteria.

Methods:
In our suggested framework, there are three stages to follow: First, we present a comprehensive categorization of machine learning-based techniques as a chemogenomic approach for drug-target interaction prediction problems; Second, to evaluate the proposed classification, several general criteria are provided; Third, unlike other surveys, according to the evaluation criteria introduced in the previous stage, a comparative analytical evaluation is performed for each approach.

Results:
This systematic research covers the earliest, most recent, and outstanding techniques in the DTI prediction problem and identifies the advantages and weaknesses of each approach separately. Additionally, it can be helpful in the effective selection and improvement of DTI prediction techniques, which is the main superiority of the proposed framework.

Conclusion:
This paper gives a thorough overview to serve as a guide and reference for other researchers by providing an analytical framework which can help to select, compare, and improve DTI prediction methods.
L-Tartaric Acid Exhibits Antihypertensive and Vasorelaxant Effects:
The Possible Role of eNOS/NO/cGMP Pathways
Authors: Amssayef Ayoub , Bouadid Ismail , Eddouks Mohamed 
Published: January 2023

Aims:
The aim of the study was to investigate the antihypertensive effect of L-Tartaric
acid.

Background:
L-Tartaric acid (L-TA) is a well-known weak organic acid that naturally occurs in a
wide range of fruits, most notably in grapes, tamarind, and citrus.

Objective:
The present study aimed to assess the effect of acute and subchronic administration of
L-TA on blood pressure parameters in normotensive and hypertensive rats as well as its vasorelaxant
potency.

Methods:
In the current study, the antihypertensive activity of L-TA was pharmacologically studied.
L-NAME-induced hypertensive and normotensive rats received L-TA (80 and 240 mg/kg)
orally over six hours for the acute experiment and seven days for the subchronic treatment. Thereafter,
systolic, diastolic, mean, mid arterial blood pressure, and pulse pressure as well as heart rate
were evaluated. In the in vitro experiment, the vasorelaxant ability of L-TA was performed in ratisolated
thoracic aorta.

Results:
An important drop in blood pressure was recorded in L-NAME-induced hypertensives
treated with L-TA. This molecule also produced a dose-dependent relaxation of the aorta precontracted
with norepinephrine (NEP) and KCl. The study demonstrated that the vasorelaxant capacity
of L-TA seems to be exerted through the activation of eNOS/NO/cGMP pathways.
A Study of Federated Learning with Internet of Things for Data Privacy
and Security using Privacy Preserving Techniques
Authors: Shakeer Shaik Mahamad , Babu Madda Rajasekhara 
Published: January 2023

Abstract:
Privacy leakage that occurs when many IoT devices are utilized for training centralized
models, a new distributed learning framework known as federated learning was created, where devices
train models together while keeping their private datasets local. In a federated learning setup, a
central aggregator coordinates the efforts of several clients working together to solve machine learning
issues. The privacy of each device's data is protected by this setup's decentralized training data.
Federated learning reduces traditional centralized machine learning systems' systemic privacy issues
and costs by emphasizing local processing and model transfer. Client information is stored locally
and cannot be copied or shared. By utilizing a centralized server, federated learning enables each
participant's device to collect data locally for training purposes before sending the resulting model
to the server for aggregate and subsequent distribution. As a means of providing a comprehensive
review and encouraging further research into the topic, we introduce the works of federated learning
from five different vantage points: data partitioning, privacy method, machine learning model,
communication architecture, and systems heterogeneity. Then, we organize the issues plaguing federated
learning today and the potential avenues for a prospective study. Finally, we provide a brief
overview of the features of existing federated knowledge and discuss how it is currently being used
in the field.
Studi Perencanaan Dinding Penahan Sebagai Upaya Penanganan Kelongsoran Lereng Pada Ruas Jalan Trenggalek - Ponorogo Provinsi Jawa Timur
Authors: Rosdiyono Anangga , Hendrawan Andre Primantyo , Asmaranto Runi 
Published: January 2023

Slope failure and landslide are still a seriously problem and occur on various parts in Indonesia. If this slope failure occurs, it can cause property losses and fatalities. This slope failure study is located on Trenggalek â€“ Ponorogo road (Km 16+650 â€“ Km 16+750) and (Km 17+400 â€“ Km 17+550) East Java Province which has steep topography condition.. From the results of the original slope analysis using the Geo5 software, it found that the safety factor values for slope stability was â‰¤ 1,5 without earthquake effect. As for the stability of the slope with the influence of the earthquake, the results of the safety factor for the original slopes of â‰¤ 1,1. Based on the analysis of the safety factor, the existing condition that the original slope is not safe therefor necessary to improve the slope repair using retaining wall as an effort to handle slope failure .From the results analysis slope stability of the slope again after repairing the slope with retaining wall, it show better safety without earthquake effect with value â‰¥ 1,5 and safe value of â‰¥ 1,1 due to earthquake load. Meanwhile to resolve the problem solve of slope failure using retaining wall requires a budget of Rp. 11.934.155.000.Kegagalan lereng dan tanah longsor masih menjadi masalah serius dan sering terjadi di berbagai wilayah Indonesia. Bila terjadi kegagalan lereng ini maka dapat menyebabkan kerugian baik secara materil dan imateril. Studi kegagalan lereng ini berada di ruas jalan Trenggalek â€“ Ponorogo (Km 16+650 â€“ Km 17+750) dan (Km 17+400 â€“ Km 17+550) Provinsi Jawa Timur dimana memiliki kondisi topografi curam. Dari berbagai macam faktor penyebab kegagalan lereng dan tanah longsor maka perlu mengetahui faktor aman lereng pada ruas jalan Trenggalek â€“ Ponorogo. Dari hasil analisis stabilitas lereng asli menggunakan bantuan software Geo5 didapatkan hasil bahwa nilai faktor aman terhadap stabilitas lerengÂ â‰¤ 1,5 tanpa adanya pengaruh gempa. Sedangkan untuk stabilitas lereng dengan pengaruh gempa didapatkan hasil faktor aman terhadap lereng alami â‰¤ 1,1. Berdasarkan analisis nilai faktor aman kondisi eksisting yang menyatakan bahwa lereng asli tidak aman oleh sebab itu, perlu adanya perbaikan lereng menggunakan dinding penahan sebagai upaya penanganan kelongsoran lereng. Dari hasil analisis stabilitas lereng kembali setelah adanya perbaikan lereng dengan dinding penahan menunjukan nilai angka aman yang lebih baik dengan kondisi tanpa gampa dengan nilai â‰¥ 1,5 dan nilai angka aman â‰¥ 1,1 akibat beban gempa. Sedangkan untuk mengatasi masalah kegagalan lereng menggunakan dinding penahan membutuhkan anggaran biaya sebesar Rp. 11.934.155.000,00.
BILATERAL PNEUMOTHORAX IN LUNG METASTASES OF BREAST CARCINOMA: A CASE REPORT
Authors: Kusdjianto Amanda Yuanita , Samsuri  , Andri  , Andi Wijayanto , Agus Subiyantoro , Adi Habibie 
Published: January 2023

Introduction: Bilateral pneumothorax is a rare case which happens in 1.3 to 1.9 percent of all cases ofÂ pneumothorax.1 In breast carcinoma patients, it is due to lung metastasis and first selected conservative therapy.2 Lung metastasis can be found in the appearance of pulmonary nodules called cannon-ball metastases in chest X-Ray (CXR).3 Method: Case report based on findings in chest X-Ray. Result: A 42 year-old female came to ER with sudden shortness of breath and pleuritic pain. She was diagnosed with breast carcinoma 3 years prior the ER visit and had undergone mastectomy on breasts and chemotherapy. Physical examination showed bilaterally decreased breath sounds. CXR AP postion showed bilateral pneumothorax and multiple nodules varied in size indicated lung metastases. Chest tubes with water-sealed drainage were inserted in both side of the lungs. CXR after the insertion showed reduction of the volume of pneumothorax in both side of the lungs and cannon-ball metastases in both sides of the lungs. CXR was performed serially until hospital discharge. Discussion: Bilateral pneumothorax which develops in patients who have history of breast carcinoma is considered very rare.It is caused by the metastatic process and treatment.2 CXR can be used to detect the metastasis and its complications such as pneumothorax.4 Conclusion: Bilateral pneumothorax is rarely seen in patients with breast carcinoma. Early detection of lung metastasis and appropriate therapy of tumor can prevent complications such as pneumothorax.Keywords: bilateral pneumothorax; lung metastases; breast carcinoma; chest X-Ray
Knowledge, Attitude and Practice toward COVID‐19 among Iraqi Adults in Karbala
Authors: Al-Ghabban Saad Ibrahim 
Published: January 2023

Objectives: to assess the knowledge, attitude and practice scores regarding COVID-19 in relation to sociodemographic states among the Iraqi adults in Karbala,
Methods: This cross-sectional population based interview survey involved 425 Iraqi adult population in Karbala, Iraq between December 2021 and February 2022 using a cluster sampling technique. Closed-ended questionnaire regarding the sociodemographic variables and questions about the knowledge, attitude and practice towards COVD-19. The data were analysed using SPSS software (version 25). The mean scores were calculated, and Independent-samples t test, one-way analysis of variance (ANOVA), or Chi-square test (X2) were used to test for differences.
Results: The mean knowledge, attitude, and practice scores were 80.67%, 54.35%, and 50.83% % of total achievable scores respectively. Females showed significantly higher knowledge attitude, and practice mean scores than males. Higher mean score of attitude was found among 18-25 years of age among those with bachelor’s degree. The unmarried showed higher scores of attitude, and practice than married. Students showed higher attitude score than other occupational groups.
Conclusion: Karbala adult population have high knowledge, negative attitude and weak practice in the precautionary measures about COVID-19, with an uneven distribution of behavioral patterns among socio-demographic subgroups. Further research targeting the vulnerable people is recommended so that the health education and communication interventions be ensured according to their needs.
Assessment of serum uric acid level in patients with systemic arterial hypertension
Authors: Abdul-Wahhab Abdul-Razzaq Mohammed , Abed Abu Saiba Mohammed , R Hadi Najah 
Published: January 2023

Objectives: To study the association between elevated serum uric acid and systemic arterial hypertension.
Methods: This study is a case-control study conducted in Al-Sadr Teaching City / Al-Najaf city from December 2019 till the end of February 2020, and included (69) cases diagnosed with systemic arterial hypertension and (71) non- hypertensive. All participants underwent anthropometric measurements and laboratory investigations for serum uric acid level, total cholesterol, high-density lipoprotein level, triglyceride level, serum blood urea and serum creatinine.
Results: The study enrolled a total of (140) participants whose mean age was (47.21 ± 12.53) years. Males comprised (57.14%) of total study sample. Serum uric acid level was found to be significantly higher among hypertensive compared to non-hypertensive, P-value = 0.003. Hyperuricemia was found to be significantly correlated with hypertension, with P-value of 0.017, Odds ratio = 9.18 (95% C.I.: 1.12 – 75.50).
Conclusions: Serum uric acid level is significantly higher in hypertensive group compared to non-hypertensive group, with the presence of significant numbers with hyperuricemia among hypertensive patients.
Rural Residence Is Associated With a Delayed Trend Away From Sulfonylurea Use for Treatment Intensification of Type 2 Diabetes
Authors: Nagy Danielle K. , Bresee Lauren C. , Eurich Dean T. , Simpson Scot H. 
Published: January 2023

OBJECTIVETo examine the intersection between location of residence along the rural–urban continuum (metropolitan, urban, and rural) and sulfonylurea dispensation records for the management of type 2 diabetes.RESEARCH DESIGN AND METHODSThis retrospective cohort study used administrative health records of adult new metformin users between April 2008 and March 2019 in Alberta, Canada. Multivariable logistic regression was performed to examine the association between sulfonylurea-based treatment intensification and location of residence.RESULTSTreatment was intensified in 66,084 (38%) of 171,759 new metformin users after a mean of 1.5 years. At treatment intensification, mean age was 55 years, 62% of users were male, and 27% were rural residents. The most common antihyperglycemic drug, given to 30,297 people (46%) for treatment intensification, was a sulfonylurea. At the beginning of our observation period, the proportion of people dispensed a sulfonylurea at first treatment intensification was highest in rural (57%), compared with urban (54%) and metropolitan (52%) areas (P = 0.009). Although proportions decreased over time across the province, rural residents continued to constitute the highest proportion of sulfonylurea users (45%), compared with urban (35%) and metropolitan (37%) residents (P &lt; 0.001), and the trend away from sulfonylurea use was delayed by ∼4 years for rural residents. Adjusting for potential sources of confounding, rural residence was associated with a significantly higher likelihood of using a sulfonylurea compared with metropolitan residence (adjusted odds ratio 1.34; 95% CI 1.29–1.39).CONCLUSIONSVariation in sulfonylurea dispensation across the rural–urban continuum provides a basis for continued research in the differences in process of care by location.
Incidence, Severity, and Presentation of Type 2 Diabetes in Youth During the First and Second Year of the COVID-19 Pandemic
Authors: Sasidharan Pillai Sabitha , Has Phinnara , Quintos Jose Bernardo , Serrano Gonzalez Monica , Kasper Vania L. , Topor Lisa Swartz , Fredette Meghan E. 
Published: January 2023

OBJECTIVE
To describe the evolving impact of the coronavirus disease 2019 pandemic on the incidence and presentation of new-onset pediatric type 2 diabetes.

RESEARCH DESIGN AND METHODS
Retrospective medical record review of youth with new-onset type 2 diabetes comparing the prepandemic period (1 January 2017–29 February 2020) with the first (1 March 2020–31 December 2020) and second pandemic year (1 January 2021–31 December 2021).

RESULTS
The annualized incidence of type 2 diabetes increased nearly threefold during the pandemic versus prior, with a 61% increase in the 2nd versus 1st year. BMI increased during the pandemic versus prior (129% of 95th percentile vs. 141%, P = 0.02). In the 1st year, patients were younger (12.9 years vs. 14.8, P &lt; 0.001), with higher incidence of diabetic ketoacidosis and/or hyperglycemic hyperosmolar syndrome (20% vs. 3.5%, P = 0.02) versus prior.

CONCLUSIONS
Providers should be aware of the escalating incidence of youth-onset type 2 diabetes to avoid delays in diagnosis and inform educational programs to combat the continued impact of the pandemic on health outcomes.
Trends in the Prevalence and Treatment of Diabetic Macular Edema and Vision-Threatening Diabetic Retinopathy Among Commercially Insured Adults Aged &lt;65 Years
Authors: Lundeen Elizabeth A. , Kim Minchul , Rein David B. , Wittenborn John S. , Saaddine Jinan , Ehrlich Joshua R. , Holliday Christopher S. 
Published: January 2023

OBJECTIVEExamine the 10-year trend in the prevalence and treatment of diabetic macular edema (DME) and vision-threatening diabetic retinopathy (VTDR) among commercially insured adults with diabetes.RESEARCH DESIGN AND METHODSWe analyzed the 10-year trend (2009–2018) in health care claims for adults aged 18–64 years using the IBM MarketScan Database, a national convenience sample of employer-sponsored health insurance. We included patients continuously enrolled in commercial fee-for-service health insurance for 24 months who had a diabetes ICD-9/10-CM code on one or more inpatient or two or more different-day outpatient claims in the index year or previous calendar year. We used diagnosis and procedure codes to calculate the annual prevalence of patients with one or more claims for 1) any DME, 2) either DME or VTDR, and 3) antivascular endothelial growth factor (anti-VEGF) injections and laser photocoagulation treatment, stratified by any DME, VTDR with DME, and VTDR without DME. We calculated the average annual percent change (AAPC).RESULTSFrom 2009 to 2018, there was an increase in the annual prevalence of patients with DME or VTDR (2.1% to 3.4%; AAPC 7.5%; P &lt; 0.001) and any DME (0.7% to 2.6%; AAPC 19.8%; P &lt; 0.001). There were sex differences in the annual prevalence of DME or VTDR and any DME, with men having a higher prevalence than women. Annual claims for anti-VEGF injections increased among patients with any DME (327%) and VTDR with DME (206%); laser photocoagulation decreased among patients with any DME (−68%), VTDR with DME (−54%), and VTDR without DME (−62%).CONCLUSIONSAnnual claims for DME or VTDR and anti-VEGF injections increased whereas those for laser photocoagulation decreased among commercially insured adults with diabetes.
Profesores de Educación: perfiles y prácticas profesionales
Authors: Vicente María 
Published: January 2023

En el marco de los cambios ocurridos en el campo profesional de las Ciencias de la Educación, el presente artículo es un trabajo de investigación cuyo objetivo es reconstruir los perfiles de los egresados en relación con: la edad, el género, la formación, la constitución familiar, el trabajo y los lugares de residencia. Para ello, se utilizan tres fuentes de datos, 730 legajos de los egresados, un cuestionario aplicado a una muestra de 92 egresados y censos o anuarios estadísticos que permiten contextualizar la unidad de análisis. Las características del perfil sociodemográfico de los egresados en Ciencias de la Educación aportan datos para avanzar con futuras investigaciones en relación a las biografías y trayectorias laborales y educativas de los egresados.
Professional, service and service-combat activity of the National Police: essence and definition of concepts
Authors: Zavistovskyi O. 
Published: January 2023

The article is devoted to research of the essence of the concepts of professional, service and service-combat activity of the National Police from the point of view of their definition in the current legislation and scientific literature, their interdependence and demarcation, including from the point of view of their definitions given in relation to the law enforcement activities of law enforcement forces and other units that perform military and law enforcement functions.
It is emphasized that the performance by police officers in accordance with the Law of Ukraine "On the National Police" of both peacetime and military service tasks introduced in Ukraine during the martial law as part of their law enforcement activities necessitates a detailed study of these concepts. If there is a distinction in the relevant Law between the terms "service" and "professional", it is noted that there is no definition of their content
Сonsidering to the contextual search in the current legislation, it was clarified that the only definition of the concept of "service activity" is proposed in the subordinate legal act of the Ministry of Internal Affairs of Ukraine, which concerns the organization and service of military units of the National Guard of Ukraine. It is noted that such a definition, although it can be taken by analogy as a basis for defining police activity, nevertheless needs to be specified in terms of the functional demarcation of bodies and units of the MIA system of Ukraine.
The definition of the service and combat activity of the National Police is given in accordance with the specifics of its service activity, and the prospective direction of legal regulation and the need for scientific substantiation of the conditions and order of belonging of the National Police not only to the law enforcement forces, but also to the security forces during the martial law in accordance with the newly introduced Paragraph 34 of Art. 23 of the Law of Ukraine "On the National Police", which is tasked with combating subversion and intelligence forces of the aggressor and paramilitary or armed formations not provided for by the laws of Ukraine in cooperation with military and other law enforcement services, bodies and units.