bluuebunny/crossref_metadata_2025_split huggingface dataset:
Glucose‐Responsive Microneedle Patch With Variable Crosslinking Density and Flexible Core–Shell Structure for Insulin Delivery
Authors: Chen Xiang , Yu Haojie , Wang Li , Shen Di , Wang Yu , Hong Yichuan 
Published: April 2023

AbstractDeveloping glucose‐responsive microneedle patches with features of simple preparation, high insulin loading, and safety has a great contribution to the treatment of diabetic patients. In this work, a novel glucose‐responsive core–shell microneedle patch is prepared from biocompatible materials by a facile process. The exterior glucose‐responsive shell is composed of polyvinyl alcohol (PVA) and ɛ‐polylysine modified with phenylboronic acid , and the inner flexible core is prepared by pure PVA loaded with insulin. The shell shows superior glucose‐induced swelling and controlled insulin release ability due to the decomposition of borate ester bonds under the synergistic effect of glucose and water. The microneedle patch also features flexibility and high insulin loading capacity (36 IU cm−2). It shows high puncture efficiency (92%) and maintains a relatively complete morphology after being removed, enabling to reduce material residues in the skin. Moreover, the microneedle patch reveals a good hypoglycemic effect in diabetic rats, achieves a hypoglycemic rate similar to that of direct injection after swelling, and works effectively to prevent excess insulin transmission. The high glucose‐responsive ability, simple preparation, high loading capacity, rapid hypoglycemic speed, high conformability to skin, and low component dissolution make this microneedle patch a suitable candidate for diabetic treatment.
Swelling under Constraints: Exploiting 3D‐Printing to Optimize the Performance of Gel‐Based Devices
Authors: Levin Michal , Cohen Noy 
Published: April 2023

AbstractStimuli‐responsive hydrogels that swell under constraints such as spatial geometric confinement are employed in many applications, including biomedical devices and actuators, to perform mechanical work. Due to the heterogeneous deformations that arise from these constraints, the computation of the swelling‐induced stress poses numerical difficulties. This work proposes a simple experimental method based on 3D‐printing technologies to characterize this stress. The swelling is investigated under two types of geometric confinements—transversely constraining and elastically constraining boxes. In the former, the box enforces uniaxial swelling of the gel. The results show that the longitudinal deformations decrease as the transverse stretches increase. The elastically constraining box comprises soft walls with various stiffnesses and sizes that deform in response to the swelling‐induced stress exerted by the gel. By employing elastic plate theory, a method to determine this stress is developed. The results reveal that: 1) the maximum volumetric deformation is achieved by free swelling and 2) the stress gels exert depends on the wall stiffness and non‐linearly decreases as the gel nears its freely swollen state. The insights from this work can be used to optimize the performance of swelling‐based systems and characterize the stress generated due to other stimuli such as pH and temperature.
An All‐In‐One Self‐Degradable Flexible Skin Patch with Thermostatic Control and Spontaneous Release of Antibacterial Ions to Accelerate Wound Healing
Authors: Liu Jiayin , Li Jiameng , Wu Ziyue , Xu Song , Wan Chunyou , Huang Xian 
Published: April 2023

AbstractSmart wound dressings supply new techniques for wound management. Nevertheless, techniques to combine microenvironment control of the wound beds and spontaneous release of antibacterial agents while reducing secondary injury of the wound due to frequent replacement of wound dressings have not been sufficiently developed. Herein, this work proposes a degradable and flexible skin patch that can assist wound healing through the combined effect of thermostatic control, slow release of antibacterial metallic ions, and humidity control. The skin patch features a degradable zinc‐silver (Zn‐Ag) gird line heater and a Zn temperature sensor fabricated through screen printing and water sintering. The sintered degradable patterns of Zn‐Ag and Zn offer electrical conductivities of 307664.4 and 72400 S m−1, enabling closed‐loop thermostatic control of the wound under a temperature range of 43 ± 2 °C. The gradual degradation of the nanocomposites in a humid environment results in an antibacterial effect with more than 99% antibacterial efficiency (AE) on the wound site due to the release of Ag and Zn ions. The skin patches are demonstrated to improve wound healing in rats and rabbits by 18.35% and 51.57%, respectively. The flexible skin patch revolutionizes the wound treatment procedure by replacing traditional wound dressing with degradable materials and flexible circuits.
Liquid Metal Coated Textiles with Autonomous Electrical Healing and Antibacterial Properties
Authors: Yang Jiayi , Nithyanandam Praneshnandan , Kanetkar Shreyas , Kwon Ki Yoon , Ma Jinwoo , Im Sooik , Oh Ji‐Hyun , Shamsi Mohammad , Wilkins Mike , Daniele Michael , Kim Tae‐il , Nguyen Huu Ngoc , Truong Vi Khanh , Dickey Michael D. 
Published: April 2023

AbstractConductive textiles are promising for human–machine interfaces and wearable electronics. A simple way to create conductive textiles by coating fabric with liquid metal (LM) particles is reported. The coating process involves dip‐coating the fabric into a suspension of LM particles at room temperature. Despite being coated uniformly after drying, the textiles remain electrically insulating due to the native oxide that forms on the LM particles. Yet, they can be rendered conductive by compressing the textile to rupture the oxide and thereby percolate the particles. Thus, compressing the textile with a patterned mold can pattern conductive circuits on the textile. The electrical conductivity of these circuits increases by coating more particles on the textile. Notably, the conductive patterns autonomously heal when cut by forming new conductive paths along the edge of the cut. The textiles prove to be useful as circuit interconnects, Joule heaters, and flexible electrodes to measure ECG signals. Further, the LM‐coated textiles provide antimicrobial protection against Pseudomonas aeruginosa and Staphylococcus aureus. Such simple coatings provide a route to convert otherwise insulating textiles into electrical circuits with the ability to autonomously heal and provide antimicrobial properties.
Large Optical Modulation of Dielectric Huygens’ Metasurface Absorber
Authors: Cheng Hao‐Yu , Ye Ming‐Jyun , Chen Wei‐Ruei , Yang Chi‐Yin , Chu Shi‐Wei , Chen Kuo‐Ping , Lin Kung‐Hsuan 
Published: April 2023

AbstractHigh‐index nanostructures are found to exhibit large nonlinearity of spectral responses under photoexcitation, which is applicable to all‐optical modulation. The nonlinearity stems from Mie‐type resonance shift due to photoinduced variation of refractive index. Here, amorphous silicon‐based Huygens’ metasurface absorber and ultrafast excitation are used to demonstrate two orders of magnitude enhancement of modulation depth, both theoretically and experimentally, when electric dipole lattice resonance matches the magnetic dipole resonance. Within a few square micrometer spatial confinement and picosecond scale delay, over 100% photothermal modulation depth is experimentally achieved at matched resonance condition. This concept is not limited to photothermal modulation in the amorphous silicon but is applicable to dielectric materials with various mechanisms to achieve modulation of refractive index. This work opens the avenue toward all‐optical information processing via optimized modulation by careful spatiotemporal and spectral control over a metasurface.
Paleoepidemiology of cribra orbitalia: Insights from early seventh millennium BP Con Co Ngua, Vietnam
Authors: Wang Tianyi , McFadden Clare , Buckley Hallie , Domett Kate , Willis Anna , Trinh Hiep H. , Matsumura Hirofumi , Vlok Melandri , Oxenham Marc F. 
Published: April 2023

AbstractObjectivesWe test the hypothesis that the condition(s) leading to the development of cribra orbitalia at Con Co Ngua, an early seventh millennium sedentary foraging community in Vietnam, effectively reduced the resilience of the population to subsequent health/disease impacts. An assessment of both the implications and potential etiology of cribra orbitalia in this specific population is carried out.MethodsThe effective sample included 141 adults aged ≥15 years (53 females, 71 males, and 17 unknown sex) and 15 pre‐adults aged ≤14 years. Cribra orbitalia was identified by way of cortical bone porosity of the orbital roof initiated within the diplöic space, rather than initiated subperiosteally. The approach is also robust to the misidentification of various pseudo‐lesions. Resultant data was analyzed using Kaplan–Meier survival analysis.ResultsMedian survival is higher in adults aged ≥15 years without cribra orbitalia than those with this lesion. For the pre‐adult cohort, the opposite pattern is seen where median survival is higher in those with cribra orbitalia than those without.ConclusionAdults displayed increased frailty and pre‐adults increased resilience with respect to cribra orbitalia. The differential diagnosis for a survival analysis of adults and pre‐adults with and without cribra orbitalia included iron deficiency anemia and B12/folate deficiency, parasitism (including hydatid disease and malaria) in addition to thalassemia. The most parsimonious explanation for observed results is for both thalassemia and malaria being the chief etiological agents, while appreciating these conditions interact with, and can cause, other forms such as hematinic deficiency anemias.
Phantom Cosmological Model with Observational Constraints in f(Q)$f(Q)$ Gravity
Authors: Narawade Shubham A. , Mishra Bivudutta 
Published: April 2023

AbstractIn this paper, the cosmological model of the Universe has been presented in gravity and the parameters are constrained from the cosmological data sets. At the beginning, a well motivated form of has been employed, where α, β, and n are model parameters. The Hubble parameter is obtained in redshift with some algebraic manipulation from the considered form of . Then it is parameterized with the recent data and data using Markov chain Monte Carlo analysis. The obtained model parameter values are validated with the baryon acoustic oscillation data set. A parametrization of the cosmographic parameters shows the early deceleration and late time acceleration with the transition at . The diagnostics gives positive slope which shows that the model is in the phantom phase. Also the current age of the Universe has been obtained as, . Based on the present analysis, it indicates that the gravity may provide an alternative to dark energy for addressing the current cosmic acceleration.
Die Erddrucktheorie von 1700 bis 1850: 250 Jahre Coulombsche Erddrucktheorie
Authors: Kurrer Karl‐Eugen 
Published: April 2023

AbstractDie Erddrucktheorie kann auf eine über 300jährige Geschichte zurückblicken. Ihre erste Hälfte wurde von französischen Ingenieuroffizieren geprägt, die sich von Sébastien le Prêstre de Vauban (1633–1707) über Bernard Forest de Bélidor (1697/98–1761) und Charles Augustin Coulomb (1736–1806) bis zu Jean‐Victor Poncelet (1788–1867) mit dem Entwurf, der Konstruktion, dem Bau und der Unterhaltung von Festungen zu befassen hatten. Dabei bildet das vor 250 Jahren der Pariser Académie Royale des Sciences vorgelegte Coulombsche Mémoire Sur une application des règles de Maximis et Minimis à quelques Problèmes de Statique, relatifs à l'Architecture – das auch bahnbrechende Erkenntnisse zur Balken‐ und Gewölbetheorie enthält – die historisch‐logische Mitte der Entwicklung der Erddrucktheorie von 1700 bis 1850. Nachfolgend wird die These entwickelt, dass die französischen Militäringenieure vom Ausgang des 17. Jahrhunderts bis zur Mitte des 19. Jahrhunderts nicht nur eine wichtige Rolle bei der Herausbildung der modernen Bauingenieurprofession spielten, sondern mit der Erddrucktheorie die erste genuin technikwissenschaftliche Theorie schufen, die das wissenschaftliche Selbstverständnis des Bauingenieurs konstituierte.
Highly efficient CRISPR‐mediated base editing for the gut Bacteroides spp. with pnCasBS‐CBE
Authors: Liang Jing , Tan Yang 
Published: April 2023

AbstractBacteroidales are the most abundant order of bacteria in the healthy human gut and have the potential as a therapeutic agent. We constructed a pnCasBS‐CBE system for base editing in the Bacteroides thetaiotaomicron to expand their genetic toolkit, which is able to efficiently convert a C:G to a T:A in the genome. As a functional proof‐of‐concept, we used the pnCasBS‐CBE system to successfully introduce nonsynonymous mutation and stop codons to the genes involved in carbohydrate metabolism. The system also allowed for multiplexed gene editing with a single plasmid, enabling efficient editing of up to four genes in a single experiment. Furthermore, the pnCasBS‐CBE editing system was validated and successfully applied in four other non‐model gut Bacteroides species for genome editing. An unbiased genome‐wide SNPs analysis indicated that the pnCasBS‐CBE system showed high fidelity and applicability. Thus, this study provides a powerful clustered regularly interspaced short palindromic repeats (CRISPR)‐mediated genome editing toolbox for functional genomic analysis in Bacteroidales.
Unusual malar rash with ulceration: What can we expect?
Authors: Chaima Kouki , Manaa Linda , Bahloul Emna , Boudaya Sonia , Amouri Mariem , Turki Hamida 
Published: April 2023

AbstractConsidering the clinical polymorphism of the disease, longstanding skin lesions located on the face, resembling erysipelas in an endemic area should always be investigated for CL and thus, atypical presentations should be kept in mind.
Gas holdup, bubble size distribution, and mass transfer in an airlift reactor with ceramic membrane and perforated plate distributor
Authors: Zhang Yanan , Lu Zhe , Qiao Yong , Guo Kai , Li Wei , Liu Hui , Li Xue , Liu Chunjiang 
Published: April 2023

AbstractThe airlift reactor is one of the most commonly used gas–liquid two‐phase reactors in chemical and biological processes. The objective of this study is to generate different‐sized bubbles in an internal loop airlift reactor and characterize the behaviours of the bubbly flows. The bubble size, gas holdup, liquid circulation velocity, and the volumetric mass transfer coefficient of gas–liquid two‐phase co‐current flow in an internal loop airlift reactor equipped with a ceramic membrane module (CMM) and a perforated‐plate distributor (PPD) are measured. Experimental results show that CMM can generate small bubbles with Sauter mean diameter d32 less than 2.5 mm. As the liquid inlet velocity increases, the bubble size decreases and the gas holdup increases. In contrast, PPD can generate large bubbles with 4 mm < d32 < 10 mm. The bubble size and liquid circulation velocity increase as the superficial gas velocity increases. Multiscale bubbles with 0.5 mm < d32 < 10 mm can be generated by the CMM and PPD together. The volumetric mass transfer coefficient kLa of the multiscale bubbles is 0.033–0.062 s−1, while that of small bubbles is 0.011–0.057 s−1. Under the same flow rate of oxygen, the kLa of the multiscale bubbles increases by up to 160% in comparison to that of the small bubbles. Finally, empirical correlations for kLa are obtained.
5‐Alkoxy‐1‐aryl‐3‐polyfluoroalkylpyrazoles with Antinociceptive Activity: Partial Agonists of TRPV1 Ion Channels
Authors: Khudina Olga G. , Burgart Yanina V. , Malkova Natalia A. , Shchegolkov Evgeny V. , Krasnykh Olga P. , Triandafilova Galina A. , Malysheva Ksenia O. , Solodnikov Sergey Yu. , Dubodel Elisaveta S. , Korolkova Yuliya V. , Kozlov Sergey A. , Borisevich Sophia S. , Mozhaitsev Evgenii S. , Saloutin Victor I. 
Published: April 2023

AbstractChemoselective O‐alkylation of 1‐aryl‐3‐polyfluoroalkylpyrazol‐5‐oles under basic conditions resulted in a series of 5‐alkoxypyrazoles (26 derivatives). They showed an acceptable ADME profile (in silico) and can be considered as drug‐like. In experiments in vivo (CD‐1 mice), it was found that the obtained compounds do not have toxic properties at a dose of more than 150 mg/kg (for most compounds at a dose of >300 mg/kg, and for lead compounds – >600 mg/kg). 22 Compounds from this series demonstrated from moderate to high analgesic effects (28–104 % at 1 h and 37–109 % at 2 h after administration) in vivo in the hot plate test (SD rats, 15 mg/kg, intraperitoneal (ip)). The lead compound was 4‐([1‐phenyl‐3‐(trifluoromethyl)pyrazol‐5‐yl]oxy)butan‐1‐ol, which not only increased the latent period in the hot plate test by 103 % at both measurement points but also showed a pronounced analgesic effect under conditions of capsaicin‐induced nociception (CD‐1 mice, 15 mg/kg, ip). According to molecular modeling, all synthesized compounds can interact with the TRPV1 ion channel. This biological target was confirmed in in vitro experiments on Chinese hamster ovary cells expressing rTRPV1. 5‐Alkoxypyrazoles were partial agonists of the TRPV1 ion channel in various degree, and the most active was the same pyrazole as in in vivo tests.
Optimization of RNA Extraction from Dry Blood Spots for Nanostring Analysis
Authors: McFarlin Brian K. , Sass Tatum N. , Bridgeman Elizabeth A. 
Published: April 2023

AbstractDry blood spot (DBS) technology has been widely used since the 1960's for the detection of protein biomarkers associated with various disease states. In this manuscript we report a revised approach using DBS samples to extract total RNA for use in downstream multiplex RNA detection methodology (Nanostring). To accomplish this objective, we have used commercially available supplies, kits, and equipment to ensure that the procedure described in this report can be adopted by any laboratory. The methods described in this report allow for the extraction of high‐quality, total RNA from a minimal volume (∼200 µl) of DBS spots. The isolated RNA can be analyzed using a multiplex, Nanostring system to yield results for up to 800 RNA targets. Additional bioinformatics and pathway annotation can be conducted to determine changes in biological signaling pathways. © 2023 Wiley Periodicals LLC.Basic Protocol: RNA extraction from DBS for multiplex RNA nanostring analysisSupport Protocol 1: RNA extraction from PAXgene bloodSupport Protocol 2: Concentration of DBS RNA
Investigation on Dynamic Impact Mechanism of Single Crystal Sapphire 3D Model Based on Cohesive Zone Law
Authors: Li Xiaolong , Wang Lifang , Li Fang 
Published: April 2023

AbstractBased on mesh reconstruction technology, a 3D solid model of single crystal sapphire (SCS) with global embedded cohesive element is established in this study. Using exponential cohesive zone law (CZL), the anisotropy of SCS can be effectively characterized by assigning the mechanical properties of matrix element and cohesive element. Taking the C‐plane SCS model as the research object, the whole process of dynamic evolution of cracks in the model under high‐speed surface impact and high concentrated stress impact is reproduced by finite element simulation technology. The simulation is compared with the experimental results from the aspects of crack initiation morphology, crack propagation path, sample fragmentation form, and mechanical response curve. The dynamic compressive strength reaches 1630.3 MPa with the impact velocity of 30 m s–1 in surface impact type. The initial maximum loading force reaches 320 N when the impact velocity is 8.35 m s–1 in the indentation impact type. In addition, by combining the simulation results, this study clarifies the mechanism of strain rate effect exhibited by SCS from the perspective of stress–strain data and crack evolution characteristics. Therefore, the model established in this study can effectively reflect the mechanical behavior of SCS under impact load.
Machine learning‐based clustering protocols for Internet of Things networks: An overview
Authors: Merah Malha , Aliouat Zibouda , Harbi Yasmine , Batta Mohamed Sofiane 
Published: April 2023

SummaryThe Internet of Things (IoT) continues to expand the current Internet, opening the door to a wide range of novel applications. The increasing volume of the IoT requires effective strategies to overcome its challenges. Machine Learning (ML) has led to a growing technology that enables computers to solve problems without the need for knowledge of their intricate details. Over the past years, various ML techniques have been used to efficiently manage IoT networks. Clustering is a technique that has proven its performance in the networking domain. Many works in the literature have studied ML‐based clustering methods for IoT networks, including their main properties, characteristics, underlying technologies, and open issues. In this paper, we focus on topology‐centered ML‐based clustering protocols for IoT networks. Specifically, we investigate the potential benefits of adopting the clustering approach to address several IoT challenges. Moreover, we provide a comprehensive taxonomy of ML‐based clustering algorithms for IoT networks. Finally, we statistically analyze the incorporation of ML techniques for clustering in various IoT systems and highlight the related open issues.
Decreasing the public health burden of eating disorders: Commentary Schleider et al. (2023)
Authors: Fitzsimmons‐Craft Ellen E. 
Published: April 2023

AbstractEating disorders (EDs) are common, disabling, and costly; yet, less than 20% of those with EDs receive treatment. EDs have also skyrocketed in the COVID‐19 pandemic, with access to care worse than ever, further solidifying the need to not only make EDs a priority but also embrace new approaches to address this major public health problem. Schleider et al. argue for the single‐session intervention (SSI) as one such option and outline an agenda that would aid in building the evidence base and realizing the promise of SSIs for EDs. This commentary details three additional key issues that need to be addressed in order to realize the full potential of SSIs and related approaches and ultimately decrease the public health burden of EDs. These include conducting work to optimize interventions for greatest effectiveness, recognizing the value and working to massively increase reach of interventions like SSIs that can scale and meet diverse needs, and engaging in the work needed to address structural barriers to widespread dissemination of these approaches. Through this agenda, we will do more than embrace a single‐session “mindset” and will catalyze the work needed to disseminate SSIs and related approaches at massive scale and maximize their impact.