bluuebunny/crossref_metadata_2025_split huggingface dataset:
KEWIRAUSAHAAN: ANALISIS PENGARUH COVID TERHADAP KEGIATAN USAHA
Authors: Marasabessy Andi Ismail , Nafis Raihan Wishal 
Published: January 2023

AbstractThis study aims to determine the impact of covid-19 on the business sector in Ambon city. This research was conducted with a descriptive qualitative approach. The research object was carried out in the city of Ambon. Data collection techniques used observation techniques and semi-structured interviews. The results show that covid-19 has an impact on the economy in Ambon city, but the increase in cases of covid-19 does not affect economic activity in Ambon city, this is evidenced by the business sector of shops and cafes that started operations and can develop during the pandemic period to date. Other results show that many of the café and tavern sector businesses survived during the pandemic.Keyword: Covid-19, Pandemic, Business Activity AbstrakPenelitian ini bertujuan untuk mengetahui dampak dari covid-19 terhadap sektor usaha di kota Ambon. Penelitian ini dilakukan dengan pendekatan kualitatif deskriptif. Objek penelitian dilakukan di kota Ambon. Teknik pengumpulan data menggunakan teknik observasi dan wawancara semi terstruktur. Hasil penelitian menunjukan bahwa covid-19 berdampak terhadap perekonomian di kota Ambon, namun peningkatan kasus covid-19 tidak mempengaruhi kegiatan perekonomian di kota Ambon, hal ini dibuktikan dengan sektor usaha kedai dan café yang memulai operasi dan dapat berkembang selama masa pandemi sampai saat ini. Hasil lain menunjukan bahwa banyak usaha sektor café dan kedai tetap bertahan sampai saat ini selama masa pandemi.Kata Kunci: Covid-19, Pandemi, Kegiatan Usaha
PENGARUH PROFITABILITAS, PERTUMBUHAN ASSET DAN UKURAN PERUSAHAAN TERHADAP STRUKTUR MODAL PADA PERUSAHAAN MANUFAKTUR DI BURSA EFEK INDONESIA (BEI)
Authors: Pelupessy Fatmah Watty 
Published: January 2023

ABSTRACT The purpose of scientific writing is to know the effect of Profitability, Asset Growth and Firm Size Of Capital Structure On Manufacturing Company in Indonesia Stock Exchange (BEI) Period 2010-2014. The analysis technique used is a statistical test with multiple regression analysis and hypothesis testing using t test (Partial Test). In the study proved that Profitability and Growth Asset partially positive and significant impact on the capital structure while variable size persahaan negative effect on Capital Structure. From this research, the R2 value of 0.683 indicating that the change amounted to 68.3%, which is caused by the independent variable (Profitability, Asset Growth and size of the company) together will affect the capital structure. While the rest of the larger, ie 31.7% explained by other variables that are not entered in the regression model in this study. Keywords: Profitability, Asset Growth, Company Size and Structure of Capital ABSTRAK Tujuan penulisan ilmiah ini adalah untuk mengetahui pengaruh Profitabilitas, Pertumbuhan Asset dan Ukuran Perusahaan Terhadap Struktur Modal Pada Perusahaan Manufaktur Di Bursa Efek Indonesia (BEI) Periode 2010-2014. Teknik analisis yang digunakan adalah uji statistik dengan metode regresi berganda dan uji hipotesis menggunakan uji t (Uji Parsial). Dalam penelitian terbukti bahwa Profitabilitas dan Pertumbuhan Asset secara parsial berpengaruh positif dan signifikan terhadap Struktur Modal sedangkan variabel Ukuran persahaan berpengaruh negatif terhadap Struktur Modal. Dari penelitian ini diperoleh nilai R2 sebesar 0,683 yang menunjukkan bahwa adanya perubahan sebesar 68.3% yang terjadi disebabkan oleh variabel independen (Profitabilitas, Pertumbuhan Asset dan Ukuran Perusahaan) secara bersama-sama akan berpengaruh terhadap Struktur Modal. Sedangkan sisanya yang lebih besar yaitu 31.7% diterangkan oleh variabel lain yang tidak di masukkan dalam model persamaan regresi pada penelitian ini.Kata Kunci: Profitabilitas, Pertumbuhan Asset, Ukuran Perusahaan dan Struktur Modal
PENGARUH NARASI BAHASA DALAM LABEL PRODUK TERHADAP PERSEPSI KONSUMEN
Authors: Masniati Andi 
Published: January 2023

AbstractThis study aims to explore how a language narrative placed on a product can influence consumer perceptions in their decision making. The strategy in placing language as the selling point of a product is a product that is characteristic of a particular region. The results of research conducted using quantitative methods with samples selected by purposive sampling and processed using regression analysis. The results of the regression test show that there is a correlation between the independent variable knowledge of narrative / label on the dependent variable of perception formed.Keywords: Language, Product Label, Perception, Consumer Behavior AbstrakPenelitian ini bertujuan mendalami bagaiman sebuah narasi Bahasa yang ditempatkan pada suatu produk mampu mempengaruhi persepsi konsumen dalam pengambilan keputusannya. Strategi dalam menempatkan bahsa sebagai nilai jual sebuah produk diantaranya merupakan produk yang berciri khas suatu wilayah tertentu. Hasil penelitian yang dilakukan menggunakan metode kuantitatif dengan sampel yang dipilih secara purposive sampling dan diolah menggunakan analisis regresi. Hasil uji regresi menunjukan bahwa terdapat korelasi antara variabel independen pengetahuan narasi / label terhadap variabel dependen persepsi yang terbentuk.Kata Kunci: Bahasa, Label Produk, Persepsi, Perilaku Konsumen
INDUSTRI HALAL FASHION DI KOTA PATI: PELUANG DAN TANTANGAN
Authors: Rizkyana Elza , Syafa'ah Putri , Husnurrosyidah Husnurrosyidah 
Published: January 2023

AbstractThis study aims to determine the magnitude of the opportunities and challenges that must be faced in developing the halal fashion industry in the city of Pati. This type of research is a field research with a qualitative descriptive method, using primary and secondary data sources. The results of the study show: 1) Pati City has a great opportunity in developing the halal fashion industry, which is marked by high consumer interest in halal fashion, the number of business actors in the fashion sector, and the availability of various halal fashion products. 2) The challenges that need to be faced in the process of developing halal fashion in the city of Pati, namely the awareness of the people of Pati in covering their genitals is still lacking, halal certification is not yet owned by fashion business actors, and the lack of public understanding of the concept of halal in fashion (halal awareness).Keyword: Halal Industry, Halal Fashion, Halal Fashion Indicator AbstrakPenelitian ini bertujuan untuk mengetahui besarnya peluang dan tantangan yang harus dihadapi dalam mengembangkan industri halal fashion di kota Pati. Jenis penelitian ini adalah penelitian lapangan (field research) dengan metode deskriptif kualitatif, menggunakan sumber data primer dan sekunder. Hasil penelitian menunjukkan: 1) Kota Pati memiliki peluang besar dalam mengembangkan industri halal fashion, yang ditandai dengan tingginya minat konsumen terhadap fashion halal, banyaknya pelaku usaha di bidang fashion, dan ketersediaan produk fashion halal yang beragam. 2) Tantangan yang perlu dihadapi dalam proses pengembangan halal fashion di kota Pati, yakni kesadaran masyarakat Pati dalam menutup aurat masih kurang, sertifkasi halal yang belum dimiliki oleh pelaku usaha fashion, serta kurangnya pemahaman masyarakat akan konsep halal dalam fashion (halal awareness).Kata Kunci: Industri Halal, Fashion Halal, Indikator Halal Fashion
KAJIAN PENGENDALIAN PERSEDIAAN OBAT DI INSTALASI FARMASI DINAS KESEHATAN KABUPATEN “X” JAWA TENGAH
Authors: Munisih Siti , Setiawati H Maria Caecilia N. , WS FX Sulistiyanto 
Published: January 2023

ABC critical index analysis is a combination of ABC analysis which includes ABC analysis of value in use and ABC analysis of investment value. The ABC analysis method is a method of making classifications based on the set of values from the highest to the lowest value and is divided into 3 major groups called group A (high investment value), B (medium investment value), and C (low investment value).The purpose of this study was to determine the compatibility, and realization and provide an evaluation of the planning for the use of drugs using the ABC method in the pharmaceutical installation health department of “X” district, Central Java. The sampling technique used in this research is purposive sampling where the sample is taken according to the sample criteria.Data on Usage Reports and Drug Request Sheets for all UPTD Public Health Centers of “X” Regency from January - December 2019 and January - December 2020. In the use of drugs in 2019 there were 343 types of drugs, consisting of group A as many as 64 drug items (18.66%) with a procurement cost of Rp. 3,647,892,228.00,- (74.83%), group B as many as 98 drug items (28.57%) with a cost of Rp. 980.902.019.40,- (20.12%). While those included in group C were 181 items (52.77%) with a cost of Rp. 246.216,758.60,- (5.29%). The results show that the budget needed for drug procurement in 2019 is IDR 4,875,011,006,00, - in 2020 there are 487 types of drugs, group A consists of 50 drug items (10.27%) with procurement costs of IDR 5,167,276,066 ,00,- (74.38%). A total of 104 drug items were included in group B (21.36%) with a cost of Rp. 1,392,954,441.00 (34.1%). While those included in group C were 333 items (68.38%) with a cost of Rp. 387,321,439.00, - (8.41%). The results show that the budget needed for drug procurement in 2020 is IDR 6,974,551,946,00,-. Keywords: compatibility, realization, evaluation, ABC
Gallium-modified gelatin nanoparticles loaded with quercetin promote skin wound healing via the regulation of bacterial proliferation and macrophage polarization
Authors: Yang Ning , Shi Nianyuan , Yao Zhou , Liu Hang , Guo Weinan 
Published: January 2023

Background: Wound healing is a complicated process involving multiple cell components and can help the re-establishment of the skin’s barrier function. Previous studies have pointed out that bacterial infection and sustained inflammatory reactions are the main causes of the delay of wound closure and scar formation during wound healing. The effect of current approaches for scar-free wound repair still faces many challenges, and alternative therapeutic methods are urgently needed to be established.Methods: The basic characteristics of the new-designed nanoparticles were clarified through the characterization of the material. The biocompatibility of the nanoparticles, as well as its effect on fibroblast function, anti-bacterial capacity, inflammation suppressive role, and the underlying mechanism were further verified by a panel of biochemical assays in vitro. Ultimately, pre-clinical rat model was employed to testify its role in wound healing and scar formation in vivo.Results: Firstly, gallium-modified gelatin nanoparticles loaded with quercetin was successfully established, displaying good biocompatibility and facilitative effect on fibroblast function. In addition, the nanoparticles showed prominent anti-bacterial and inflammation-suppressive effects. What’s more important, the nanoparticles could also induce the polarization of macrophages from M1 to M2 phenotype to exert its inflammatory inhibitory role through TGF-β/Smad signaling pathway. Ultimately, in vivo experiment showed that the nanoparticles could effectively promote wound repair and inhibit scar formation during the process of wound healing.Conclusion: Taken together, the new nanoparticles have good anti-bacterial and anti-scar formation effects and great potential in the field of skin wound repair, which provides a promising therapeutic strategy for wound treatment.
The relationship between national cultural dimensions, maternal anxiety and depression, and national breastfeeding rates: An analysis of data from 122 countries
Authors: Rajkumar Ravi Philip 
Published: January 2023

IntroductionBreastfeeding is a natural and universal practice across countries and cultures. It is estimated that several thousand lives could be saved per year if optimal breastfeeding practices were adopted across countries. In addition, breastfeeding has numerous health, emotional and developmental benefits for both the mother and her infant. Despite widespread awareness of these benefits, rates of breastfeeding initiation and maintenance remain suboptimal, both in high- and in low- and middle-income countries. Unfavorable breastfeeding outcomes are related to several factors, including variations in cultural values and the occurrence of common mental disorders in women during pregnancy and in the postnatal period. However, the relative contributions of culture and mental health to variations in national breastfeeding rates have not been examined to date.MethodsIn the current study, recent United Nations International Children's Emergency Fund (UNICEF) data on lifetime breastfeeding rates is analyzed in two stages, to first explore and then confirm the impact of cultural values and maternal mental health status at a cross-national level.ResultsIt was found that the estimated prevalence of both depression and anxiety disorders in women of childbearing age was negatively correlated with breastfeeding rates. Significant associations were also observed for the cultural dimensions of individualism-collectivism and masculinity-femininity. The association between anxiety disorders and breastfeeding outcomes remained significant in multivariate analysis incorporating demographic and health variables that could exert a confounding effect.DiscussionThese results suggest that both cultural values and the assessment and treatment of maternal mental illness should be components of any programme aimed at communicating the benefits of breastfeeding or at improving breastfeeding outcomes. The inclusion of these components could help promote the values of cultural sensitivity, inclusiveness and equity in breastfeeding from a global perspective.
Plasma homocysteine levels and risk of congestive heart failure or cardiomyopathy: A Mendelian randomization study
Authors: Wang Xinyi , Chen Zhuo , Tian Wende , Zhang Jie , Li Qiuyi , Ju Jianqing , Xu Hao , Chen Keji 
Published: January 2023

BackgroundAlthough observational studies have demonstrated associations between elevated plasma homocysteine levels and the risk of cardiovascular diseases, controversy remains.ObjectiveThis study investigated the causal association of plasma homocysteine levels with congestive heart failure and cardiomyopathy risk.MethodsWe performed a two-sample Mendelian randomization (MR) study of congestive heart failure (n = 218,792), cardiomyopathy (n = 159,811), and non-ischemic cardiomyopathy (n = 187,152). Genetic summary data on the association of single-nucleotide polymorphisms with homocysteine were extracted from the most extensive genome-wide association study of 44,147 individuals. MR analyses, including the random-effect inverse variance-weighted (IVW) meta-analysis, weighted median, simple median, maximum likelihood, penalized weighted median, MR-PRESSO, and MR-Egger regression, were used to estimate the associations between the selected single-nucleotide polymorphisms and congestive heart failure or cardiomyopathy.ResultsThe MR analyses revealed no causal role of higher genetically predicted plasma homocysteine levels with congestive heart failure risk (random-effect IVW, odds ratio [OR] per standard deviation (SD) increase in homocysteine levels = 1.753, 95% confidence interval [CI] = 0.674–4.562, P = 0.250), cardiomyopathy (random-effect IVW, OR per SD increase in homocysteine levels = 0.805, 95% CI = 0.583 to 1.020, P = 0.189), or non-ischemic cardiomyopathy (random-effect IVW, OR per SD increase in homocysteine levels = 1.064, 95% CI = 0.927–1.222, P = 0.379). The results were consistent with other analytical methods and sensitivity analyses.ConclusionGenetically predicted homocysteine level was not associated with congestive heart failure or cardiomyopathy risk. It is unlikely that homocysteine-lowering therapy decreases the incidence or improves the outcomes of congestive heart failure and cardiomyopathy.
Mineralization age and genesis of the makeng-style iron deposits in the Paleo-Pacific tectonic domain of South China: In situ LA-ICPMS garnet U-Pb chronological and geochemical constraints
Authors: Wang Sen , Cao Ke , Zhang Da , Yi Jin-Jun , Hu Bo-Jie , Yang Jing , Cai Meng-Ying , Zhang Yao-Yao , Yuan Yuan , Pan Tian-Wang 
Published: January 2023

To reveal the genesis of Makeng-style iron polymetallic deposits from SE China in the paleo-Pacific tectonic domain, a new analytical method of LA-ICPMS garnet U-Pb dating and rare Earth element analysis was conducted for the Makeng, Luoyang, Dapai and Pantian deposits. The U-Pb dating results of nine garnet skarn samples from these deposits suggested that the Makeng-style iron polymetallic deposits mainly formed during 137–130 Ma, which is consistent with the zircon U-Pb and molybdenite Re-Os ages. This study provides more direct evidence of the mineralization age and the relationship between mineralization and granite, compared with previous studies on the zircon U-Pb dating for granites in the ore fields. Rare Earth element (REE) analysis results and REE patterns of four representative garnet samples from the Makeng, Luoyang, Dapai and Pantian deposits show that they are similar to typical skarn deposits, but obvious differences in the REE distribution types indicate that the ore-forming process may be distinct due to different mineralizing fluid for these Makeng-style deposits. Our new garnet U-Pb dating and rare Earth element analysis result not only provides new evidence for the mineralization age and genesis of the Makeng-style deposits but is also of great significance to promote the application of U-Pb dating methods to research skarn type deposits.
Sub-macroscopic skin presentation of acromegaly and effect of pituitary tumor surgery: A study using dermatoscopy and ultra-high-frequency ultrasound
Authors: Guo Xiaopeng , Wang Yukun , Yao Yong , Bao Xinjie , Duan Lian , Zhu Huijuan , Xing Bing , Liu Jie 
Published: January 2023

ObjectiveExcessive growth hormone and insulin-like growth factor 1 contribute to cutaneous changes in acromegaly. We investigated the sub-macroscopic skin manifestation of acromegaly patients and explored its reversibility upon hormone reduction after pituitary adenoma surgery.DesignProspectively cohort study.MethodsWe enrolled 26 patients with acromegaly and 26 patients with non-functioning pituitary adenomas undergoing pituitary adenomectomy at Peking Union Medical College Hospital from July 2021 to March 2022. Skin presentations were evaluated by dermatoscopy and ultra-high-frequency ultrasound before and after surgery.ResultsSkin thickening, follicular plugs, perifollicular pigmentations, perifollicular orange haloes, red structureless areas, increased hair shafts, honeycomb-like pigmentations, widened dermatoglyphics, dilated appendage openings, excessive seborrhea, hyperhidrosis, enlarged pores, and acne-like lesions were commonly occurring in acromegaly patients, and their incidences were higher than the controls (P&lt;0.05). At 3-month follow-up after surgery, the thickness of skin reduced (4.0 ± 0.4 to 3.7 ± 0.4, P=0.007), the incidences of hyperhidrosis (92.3% to 69.2%, P=0.035) and acne-like lesions (53.8% to 26.9%, P=0.048) declined, and the severity of multiple cutaneous lesions improved. Patients with surgical endocrine remission (53.8%) had greater declines in the thickness of skin than those without remission. Patients with improvement of &gt;1 skin lesions were younger (P=0.028) and had higher baseline GH levels (P=0.021) than those with improvement of ≤1 skin lesion.ConclusionsDermatoscopy and ultra-high-frequency ultrasound provided augmented visual examination of the cutaneous changes in acromegaly. Some of the skin lesions could improve or reverse after pituitary surgery. Baseline GH levels, age, and endocrine remission were correlated with skin improvement at 3-month follow-up.
Responses of Phytoplanktonic Chlorophyll-a Composition to Inorganic Turbidity Caused by Mine Tailings
Authors: Nunes Patrícia , Roland Fabio , Amado André M. , Resende Nathália da Silva , Cardoso Simone Jaqueline 
Published: January 2023

Inorganic turbidity can limit light penetration in water and reduce phytoplankton photosynthesis. Anthropogenic activities such as mining can produce or augment the amount of suspended inorganic particles in water. Recent mining disasters in Brazil have released tons of mine tailings into aquatic ecosystems, with known and unknown negative consequences for aquatic life, biodiversity, and ecosystem services beyond the human and material losses. Here, we investigated the effects of inorganic turbidity on phytoplankton chlorophyll content and composition caused by sediments from two areas in Lake Batata, one natural and the other impacted by bauxite tailings. We experimentally compared the effects of different levels of turbidity (12, 50, and 300 NTU) caused by the addition of sediments from the two lake areas on a chlorophyll-a gradient (5, 15, and 25 μg/L). Inorganic turbidity did not consistently reduce chlorophyll-a concentrations. In treatments with high chlorophyll-a, high turbidity was associated with lower chlorophyll-a concentrations at the end of the experiment. On the other hand, in low-chlorophyll treatments, high turbidity was associated with higher chlorophyll-a concentrations. In treatments with sediments from the natural area, overall chlorophyll-a levels were higher than in treatments with sediments from the impacted area. Phagotrophic algae dominated both in treatments with sediments from the impacted area (Chrysophyceae 34%, Chlorophyceae 26%, and Cyanobacteria 22% of total density) and in treatments with sediment from the natural area (Euglenophyceae 26%, Chrysophyceae 23%, and Chlorophyceae 20%). We conclude that high turbidity does not lead to a reduction in chlorophyll-a concentrations and sediment from the natural area allowed higher chlorophyll-a levels, indicating that impacted area sediment affected more phytoplankton.
An investigation of the influence of the morphological indexes of trees on the outdoor microclimate at high altitude in summer
Authors: Zhang Yingzi , Chen Lixing , Sun Chen , Fu Yunchao , Xie Yibing 
Published: January 2023

Trees have significant effects of shading, humidifying, and cooling, and at the same time, they can create a more comfortable space for people. However, due to the complexity of their own biology, there are also some differences in the regulation mechanism of the space microclimate among different trees. Under the background of a high altitude and cold climate, based on field measurements and numerical simulation, this paper discussed the effects of the morphological indexes, including the height, crown width, leaf area index (LAI), and under branch height of trees and their interactions on the urban microclimate and thermal comfort in Lhasa city, which belongs to the Warm Summer Winter Dry Cold Climate (Dwb). The study revealed the following: 1) LAI is the key factor affecting the thermal environment and thermal comfort of the space under a tree, followed by height and crown width, and the improvement potential of under branch height is relatively weak. 2) The interaction between height and LAI and crown width affects the thermal comfort of the space under a tree. 3) In summer, the optimal combination of tree morphological indexes in Lhasa is LAI = 2, height = 12 m, crown width = 11 m, ground reflectance = 0.2.