bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of a Novel Application of the Capture-Trap-Terminate Approach for Treating Aerosol Products During Dental Procedures
Authors: Anshar Muh , Marlina Erni , Yoanita Yossy , Ruslin Muhammad , Djamaluddin Dewiani , Arsyad Thaha Muhammad , Rusman Muhammad , Hajrah Yusuf Andi Sitti 
Published: September 2023

Abstract
The present study aimed to report a novel developed technology for disinfecting pathogens in aerosols produced by dental health applications. The proposed method was integrated into a disinfection room installed inside an extraoral dental aerosol suction system. The experimental phase was designed to measure the application of the system during dental care management. These experiments assessed the effectiveness of the proposed mechanism in disinfecting captured micro-organisms. The results showed that the system reduced the quantity and coverage area of harmful splatters and aerosols by ∼50%. Future studies should verify the effectiveness of the approach for measuring the temperature inside the disinfection room and the number of pathogens, including coronavirus, that remain after the disinfection process.
Association of IFNAR2 rs2236757 and OAS3 rs10735079 Polymorphisms with Susceptibility to COVID-19 Infection and Severity in Palestine
Authors: Abdelhafez Mohammad , Nasereddin Abedelmajeed , Shamma Omar Abu , Abed Rajaa , Sinnokrot Raghida , Marof Omar , Heif Tariq , Erekat Zaid , Al-Jawabreh Amer , Ereqat Suheir 
Published: September 2023

The clinical course and severity of COVID-19 vary among patients. This study aimed to investigate the potential correlation between the gene polymorphisms of the interferon receptor (IFNAR2) rs2236757 and oligoadenylate synthetase 3 (OAS3) rs10735079 with the risk of COVID-19 infection and its severity among Palestinian patients. The study was conducted between April and May 2021 on 154 participants who were divided into three groups: the control group (RT-PCR-negative, n = 52), the community cases group (RT-PCR-positive, n = 70), and the critically ill cases (ICU group; n = 32). The genotyping of the investigated polymorphisms was performed using amplicon-based next-generation sequencing. The genotypes distribution for the IFNAR2 rs2236757 was significantly different among the study groups (P = 0.001), while no statistically significant differences were found in the distribution of genotypes for the OAS3 rs10735079 (P = 0.091). Logistic regression analysis adjusted for possible confounding factors revealed a significant association between the risk allele rs2236757A and critical COVID-19 illness

P

<

0.025

. Among all patients, those who carried the rs2236757GA were more likely to have a sore throat (OR, 2.52 (95% CI 1.02–6.24); P = 0.011); the presence of the risk allele rs2236757A was associated with an increased risk to dyspnea (OR, 4.70 (95% CI 1.80-12.27);

P

<

0.001

), while the rs10735079A carriers were less likely to develop muscle aches (OR, 0.34 (95% CI 0.13–0.88); P = 0.0248) and sore throat (OR, 0.17 (95% CI 0.05–0.55);

P

<

0.001

). In conclusion, our results revealed that the rs2236757A variant was associated with critical COVID-19 illness and dyspnea, whereas the rs10735079A variant was protective for muscle aches and sore throat.
Approach of Chronic Pelvic Pain with Top Flat Magnetic Stimulation
Authors: Salsi Benedetta , Ganassi Giulia , Lopopolo Graziella , Callarelli Silvia , Comito Alessandra , Fusco Irene , Isaza Pablo González 
Published: September 2023

Background and Objectives. Pelvic floor tension myalgia (PFTM) represents a pelvic floor dysfunction related to increased activity or hypertonicity of pelvic floor muscles that leads to chronic pelvic pain or miofascial syndrome. In the current research, we assess the efficacy and safety of a device that uses top flat magnetic stimulation for the management of hypertonicity in women with chronic pelvic pain and interstitial cystitis. Materials and Methods. Vulvar Functional Status Questionnaire (VQ) was used for the evaluation of patient’s chronic pelvic pain and muscle hypertone improvements. The interstitial cystitis was assessed by the Leary–Sant symptom and problem indexes (ICSI and ICPI). In this study, the scores resulting from the sum of the two indexes were evaluated as OSS (ICSI + ICPI). Results. Women with chronic pelvic pain and muscle hypertone showed VQ mean values significantly lower than the controls

p

<

0.005

from the second treatment up to the sixth one. In 6 patients affected by interstitial cystitis, the mean score of OSS was significantly lower than the controls

p

<

0.005

from the second treatment up to 2 months follow-up after the last treatment session. No side effects were observed. Conclusion. Based on these results, this technology may successfully manage muscle hypertonicity condition, the chronic pelvic pain, and interstitial cystitis.
Outcomes of Hip Arthroscopy in the Setting of Concomitant Symptomatic Lumbosacral Spine Pathology: A Matched Control Study With Minimum 24-Month Follow-up
Authors: Torabian Kaveh A. , Cherian Nathan J. , Dean Michael C. , Eberlin Christopher T. , Kucharik Michael P. , Dowley Kieran S. , LaPorte Zachary L. , Martin Scott D. 
Published: September 2023

Background: The overlapping biomechanical relationship between the lumbosacral spine and pelvis poses unique challenges to patients with concomitant pathologies limiting spinopelvic range of motion. Purpose: To assess the influence of concomitant, symptomatic lumbosacral spine pathology on patient-reported outcome measures (PROMs) after hip arthroscopy for the treatment of femoroacetabular impingement (FAI) and symptomatic labral tears. Study Design: Cohort study; Level of evidence, 3. Methods: A retrospective query of prospectively collected data identified patients aged ≥18 years with a minimum 24-month follow-up who underwent hip arthroscopy by a single surgeon for the treatment of symptomatic labral tears secondary to FAI. Patients were stratified into cohorts based on the presence (hip-spine [HS]) or absence (matched control [MC]) of symptomatic lumbosacral spine pathology. Inclusion within the HS cohort required confirmation of lower back pain/symptoms on preoperative surveys plus a diagnosis of lumbosacral spine pathology verified by radiology reports and correlating clinical documentation. Patients with previous spine surgery were excluded. PROMs were compared between groups, along with rates of achieving minimal clinically important difference (MCID) thresholds, Patient Acceptable Symptom State (PASS) thresholds, revision arthroscopy, and conversion to total hip arthroplasty (THA). Results: A total of 70 patients with lumbosacral pathology were coarsened exact matched to 87 control patients without spinal pathology. The HS cohort had preoperative baseline scores that were significantly worse for nearly all PROMs. Follow-ups at 3, 6, 12, and 24 months displayed similar trends, with the HS cohort demonstrating significantly worse scores for most collected outcomes. However, at every time point, HS and MC patients exhibited similar magnitudes of improvement across all PROM and pain metrics. Furthermore, while significantly fewer HS patients achieved PASS for nearly all PROMs at 12- and 24-month follow-ups, MCID thresholds were reached at similar or greater rates across all PROMs relative to the MC cohort. Finally, there were no significant differences in rates of revision or THA between cohorts at maximum available follow-up. Conclusion: After hip arthroscopy to address labral tears in the setting of FAI, patients with symptomatic lumbosacral pathologies and no history of spine surgery were found to exhibit inferior pre- and postoperative PROMs but achieved statistically similar clinical benefit and rates of PROM improvement through 24-month follow-up compared with the MC cohort with isolated hip disease. These findings aid in providing a realistic recovery timeline and evidence that coexisting hip and spine disorders are not a contraindication for arthroscopic hip preservation surgery.
In Vivo Effect of Partial Ulnar Collateral Ligament Tear Location on Ulnohumeral Joint Gapping With Stress Ultrasound in Baseball Pitchers
Authors: Ciccotti Michael C. , Paul Ryan W. , Gawel Richard J. , Erickson Brandon J. , Dodson Christopher C. , Cohen Steven B. , Nazarian Levon N. , Ciccotti Michael G. 
Published: September 2023

Background: Stress ultrasonography (SUS) has provided clinicians with an alternative means of evaluating ulnar collateral ligament (UCL) injury by dynamically assessing ulnohumeral joint space gapping under applied valgus stress. However, 3 previous cadaveric studies have evaluated the biomechanical effect of partial UCL tears at different anatomic locations with conflicting results. Purpose/Hypothesis: The purpose of this study was to use in vivo data from patients with magnetic resonance (MR)–confirmed partial UCL tears to determine if anatomic partial tear location influenced the resultant stability of the elbow in terms of ulnohumeral joint gapping on SUS. It was hypothesized that no difference would be seen in the amount of ulnohumeral joint gapping based on MR-identified anatomic partial UCL tear location. Study Design: Cohort study; Level of evidence, 3. Methods: All patients diagnosed with elbow injury from 2015 to 2020 were screened to identify competitive baseball pitchers with a partial UCL tear who received an SUS. Partial UCL tear was diagnosed via surgeon and radiologist interpretation of elbow MR imaging (MRI) as well as confirmation at the time of surgery as documented in the operative report. Demographic, injury, and treatment data were collected from the clinic notes, MRI reports, and stress ultrasound reports. Ulnohumeral joint gapping on SUS was calculated as the difference between ulnohumeral joint gapping without valgus stress versus ulnohumeral joint gapping with valgus stress (delta) as performed by a musculoskeletal radiologist. Results: Overall, 60 male baseball pitchers (age, 19.2 ± 2.1 years), including 22 (37%) high school, 26 (43%) collegiate, and 12 (20%) professional pitchers, were evaluated. Regarding the location of partial UCL tears, 32 (53%) pitchers had proximal tears and 28 (47%) had distal tears. The mean delta value cohort was 2.1 ± 1.1 mm, and 34 pitchers (57%) had delta values >2.0 mm. Ulnohumeral joint gapping (high school [1.9 mm] vs collegiate [2.6 mm] vs professional [1.6 mm]; P = .004) and the percentage of pitchers with delta values >2.0 mm (45% vs 77% vs 33%; P = .017) differed based on level of competition. After controlling for age, body mass index, and level of competition in a multivariate linear regression, tear location was not related to ulnohumeral joint gapping ( P = .499). Conclusion: No difference was observed in the amount of ulnohumeral joint gapping on SUS in symptomatic baseball pitchers with MR-identified partial UCL tears at differing anatomic locations. The findings of this study are contrary to previous cadaveric studies that have evaluated the effects of UCL tear characteristics on delta laxity.
A Survey on Alveolar Bone Grafting in Indian Cleft Centers
Authors: Thiruvenkatachari Badri , Prathap Manoj , Jauhar Preeti , Batra Panchali , Shetty Preetham , Subash Pramod 
Published: September 2023

Objective To assess the factors influencing the type and timing of Alveolar Bone Grafting (ABG) among cleft centers throughout India. To examine the decision-making criteria for orthodontic treatment and the timing of ABG. Design Cross sectional survey Method This survey was based on a convenience-based sample selected from cleft teams across India. The survey was formulated using the SurveyMonkey platform and emailed to 40 cleft teams. The survey included questions on demographics, timing, surgical protocol, orthodontic protocol, radiograph prescription rate, assessment methods for the success of ABG and three scenarios for evaluating the timing of the bone graft. The Chi-squared test was performed to evaluate the difference in opinion between specialists. The inter-examiner reliability was assessed using Kappa statistics. Results Thirty-five units completed the questionnaire. Most units operate with 1-2 surgeons, with 42.9% of them treating cleft patients for under 5 years. Only 11.4% of centres routinely advised oblique occlusal radiographs for post-surgery evaluation, and 31.4% prescribed CBCT. However, 40% of cleft teams did not perform audits to evaluate the success of ABG, and less than 50% advised radiographs six months post-surgery. Around 26% of centres do not routinely provide orthodontic treatment pre-ABG. The inter-examiner reliability for case scenarios showed poor agreement between the clinicians. Conclusion The survey showed a serious lack of consensus in the ABG treatment among cleft teams in India and emphasises the need for standardised protocols for the treatment of children with cleft palate. There is an urgent need to develop core outcome set in cleft.
The Interplay Between Blood Inflammatory Markers, Symptom Domains, and Severity of ADHD Disorder in Children
Authors: Abdel Samei Afaf Mohammed , Mahmoud Dalia Abdel Moneim , Salem Boshra Beshoy , Abd El Moneam Mohamed Hossam El-Din 
Published: September 2023

Objective: ADHD has a multi-factorial etiology among which the inflammatory theory presupposition. We aimed to explore the interplay between blood inflammatory markers; neutrophil lymphocyte ratios (NLR), platelet\lymphocyte ratio (PLR), mean platelet volume (MPV), symptom domains, and severity of ADHD. Method: A total of 50 children with ADHD and 50 healthy controls were recruited. Children were assessed using the mini-international neuropsychiatric interview for children and adolescents (MINI-KID), the Wechsler intelligence scale for children, the Conners’ parent rating scale. Then, NLR, PLR, and MPV were measured. Results: There was a statistically significant difference between children with ADHD and the control group with regard to all blood inflammatory markers (except platelet count). The subtypes and severity of ADHD had no significant relation with NLR, PLR, and MPV. Conclusion: blood inflammatory markers are significantly high in children with ADHD but could not predict specific symptom domains or severity.
Exudative vascular anomalous complex-like lesion of the peripapillary area
Authors: Temkar Shreyas , Natarajan Kaviyapriya , Deb Amit Kumar , Sagar Pradeep 
Published: September 2023

Purpose Perifoveal exudative vascular anomalous complex is an uncommon retinal lesion of idiopathic origin characteristically described as an isolated, aneurysmal lesion of the perifoveal region. We report an unusual presentation of an exudative vascular anomalous complex-like lesion affecting the peripapillary area. Case description A 69-year-old diabetic woman presented with blurred vision in her left eye for two months. Fundus examination of the left eye showed a small, reddish-orange lesion just supratemporal to the optic disc with perifoveal hard exudates and retinal thickening. Fundus fluorescein angiography demonstrated a peripapillary hyperfluorescent lesion with minimal leakage. Ocular coherence tomography showed an oval structure extending throughout the outer and inner plexiform and nuclear layers with a hyper-reflective wall accompanied by subfoveal and intraretinal fluid suggestive of an eVAC-like lesion in the peripapillary area. Intravitreal anti-vascular endothelial growth factor injection was given, and the lesion persisted even three weeks after the injection. Later, focal laser photocoagulation of the aneurysmal lesion was done. At 6 weeks follow-up, a complete resolution of the aneurysmal lesion with a marked decrease in retinal edema and an improvement of the visual acuity was observed. Conclusion Exudative intraretinal aneurysmal lesions can occur in areas other than perifoveal area. OCT is an useful investigation for knowing their characteristics and the response to treatment. These aneurysmal lesions irrespective of their location can be called by the name eVAC-like or more aptly retinal capillary macro aneurysms (RCM).
Well-being at midlife: Correlates of mental health in ambulatory menopausal women with multiple sclerosis
Authors: Morales-Rodriguez Denisse , Anderson Annika , Nylander Alyssa , Hsu Stephanie , Singh Jessica , Rowles Will , Walsh Christine M , Braley Tiffany J , Bove Riley 
Published: September 2023

Background: A majority of women with multiple sclerosis (MS) are diagnosed prior to menopause, yet their experiences during this transition are not well characterized. Objectives: To explore associations between mental health, sleep, and other quality of life metrics, and vasomotor symptoms (VMSs) in ambulatory, menopausal women with MS. Methods: A secondary analysis was performed of baseline data from two trials enrolling ambulatory peri/postmenopausal women with MS: NCT02710214 ( N = 24, bothersome VMS) and NCT04002934 (ongoing, N = 35, myelin repair). Measures analyzed were 36-Item Short-Form Survey (SF-36) (primary scale: general mental health), subjective sleep quality (Pittsburg Sleep Quality Index), VMS (daily diary, interference), mood (Center for Epidemiologist Studies—Depression Scale (CES-D)), walking impairment (timed 25-foot walk (T25FW)), and global disability (Expanded Disability Status Scale (EDSS)). Results: Participants’ characteristics ( N = 59) were: mean age 51.8 years ( SD = 3.4), mean disease duration 11.3 years ( SD = 7.6), median EDSS 3.0 (IQR = 2.0–4.0). Mental health was associated with better sleep quality (rho = −0.41, p = 0.019) and better mood (rho = −0.75, p < 0.001), but not with EDSS or T25FW (rho < 0.20, p > 0.10). Worse sleep quality also correlated with more frequent VMS (rho = 0.41, p = 0.02) and VMS interference (rho = 0.59, p < 0.001). Conclusions: Findings suggest that optimizing sleep quality, mood, and hot flash quantity/interference could substantially improve mental health in menopausal women with MS—and highlight an important care gap in this population.
Morphological characteristics of brain aneurysms among age groups
Authors: Sanchez Sebastian , Essibayi Muhammed Amir , Hickerson Meredith , Ojeda Diego J , Kasab Sami Al , Yoshimura Shinichi , Jabbour Pascal M. , Mascitelli Justin , Levitt Michael R. , Cuellar-Saenz Hugo H. , Brinjikji Waleed , Spiotta Alejandro M. , Shaban Amir , Samaniego Edgar A 
Published: September 2023

Background Patient's age is an important factor in determining the risk of aneurysm rupture. However, there is limited data on how aneurysm morphology differs among age groups. We studied morphological characteristics of brain aneurysms among age groups in a large cohort. Methods Aneurysms from the Stroke Thrombectomy and Aneurysm Registry (STAR) were analyzed. The following parameters were included: location, size, neck, width, height, aspect ratio, and regular versus irregular morphology. The risk of rupture presentation was estimated using logistic regression. Results A total of 1407 unruptured and 607 ruptured saccular aneurysms were included. The most common locations of ruptured aneurysms in patients younger than 70 years-old were the middle cerebral artery (MCA) and the anterior communicating artery (ACOM). The most common location of ruptured aneurysms in patients older than 70 years-old were the posterior communicating artery (PCOM) and ACOM. The size of unruptured aneurysms increased with age (p < .001). Conversely, the size of ruptured aneurysms was similar among age groups (p = .142). Unruptured and ruptured aneurysms became more irregular at presentation with older age (p < .001 and p .025, respectively). Irregular morphology and location were associated with rupture status across all age groups in multivariate regression. Conclusions Younger patients have small unruptured and ruptured aneurysms, and ruptured aneurysms are mostly located in the MCA and ACOM. Older patients have larger and more irregular unruptured aneurysms, and ruptured aneurysms are mostly located in the PCOM and ACOM. An irregular morphology increases the risk of rupture in all age groups.
Parallel Chondrogenesis and Osteogenesis Tissue Morphogenesis in Muscle Tissue via Combinations of TGF-β Supergene Family Members
Authors: Xiong Fei , Chevalier Yan , Klar Roland M. 
Published: September 2023

Objective This study aimed to decipher the temporal and spatial signaling code for clinical cartilage and bone regeneration. We investigated the effects of continuous equal dosages of a single, dual, or triplicate growth factor combination of bone morphogenetic protein (BMP)-2, transforming growth factor (TGF)-β3, and/or BMP-7 on muscle tissue over a culturing period. The hypothesis was that specific growth factor combinations at specific time points direct tissue transformation toward endochondral bone or cartilage formation. Design The harvested muscle tissues from F-344 adult male rats were cultured in 96-well plates maintained in a specific medium and cultured at specific conditions. And the multidimensional and multi–time point analyses were performed at both the genetic and protein levels. Results The results insinuate that the application of growth factor stimulates a chaotic tissue response that does not follow a chronological signaling cascade. Both osteogenic and chondrogenic genes showed upregulation after induction, a similar result was also observed in the semiquantitative analysis after immunohistochemical staining against different antigens. Conclusions The study showed that multiple TGF-β superfamily proteins applied to tissue stimulate developmental tissue processes that do not follow current tissue formation rules. The findings contribute to the understanding of the chronological order of signals and expression patterns needed to achieve chondrogenesis, articular chondrogenesis, or osteogenesis, which is crucial for the development of treatments that can regrow bone and articular cartilage clinically.
Google Maps Timeline: An open-access digital tool to monitor walking abilities in people with multiple sclerosis
Authors: Caliendo Daniele , Puca Anna , Lavorgna Luigi , Carotenuto Antonio , Petracca Maria , Lanzillo Roberta , Brescia Morra Vincenzo , Moccia Marcello 
Published: September 2023

Introduction Gait impairment is common in multiple sclerosis (MS), but difficult to evaluate in clinical practice. In this proof-of-concept observational study, we compared walking ability recorded by Google Maps Timeline to conventional clinical measures in people with MS. Methods We used open-access Google Maps Timeline to record the total number of days with walking activity, walking distance, walking time, and walking speed. Each Google Maps Timeline variable was included in a different stepwise linear regression model including all conventional clinical variables. Results We included nine people with MS (age 43.1 ± 6.6 years; females 55.6%; disease duration 12.7 ± 3.1 years; median Expanded Disability Status Scale 3.0 (range 1.0–5.5)). Higher percentage of days with recorded walking was associated with lower Fatigue Severity Scale ( p = 0.01), and higher MS Walking Scale ( p = 0.04). Longer average daily walking distance was associated with shorter Timed-25 Foot Walking Test ( p = 0.02), lower Expanded Disability Status Scale ( p = 0.01), and higher Euro-Quality of Life ( p = 0.04). Longer average daily walking time was associated with shorter Timed-25 Foot Walking Test ( p = 0.03). Higher walking speed was associated with lower Fatigue Severity Scale ( p = 0.04). Conclusion Google Maps Timeline parameters provide actual estimates of daily walking activities in MS.