bluuebunny/crossref_metadata_2025_split huggingface dataset:
Are reduced fetal movements “merely” a maternal perception or truly a reflection of umbilical cord complications? A clinical trial
Authors: Cohen Gal , Pinchas‐Cohen Tally , Blickstein Ophir , Ben Zion Maya , Schreiber Hanoch , Biron‐Shental Tal , Shechter‐Maor Gil 
Published: September 2023

AbstractObjectiveTo characterize obstetric outcomes and the association with umbilical cord (UC) complications among women complaining of reduced fetal movements (RFMs).MethodsThis retrospective cohort compared women with a perception of RFMs within 2 weeks prior to delivery with women who reported no changes in fetal movements in terms of maternal characteristics and neonatal outcomes. A primary outcome of UC complications at delivery was defined. Multivariable regression analysis was performed to identify independent associations with RFMs and UC complications.ResultsIn all, 46 103 women were included, 2591 (5.6%) of whom reported RFMs and 43 512 (94.4%) in the control group. Compared with controls, the RFM group was more likely to be nulliparous (42.6% vs 32.2%, P < 0.001), smokers (6.4% vs 5.4%, P = 0.029), or obese (body mass index >30) (16.4% vs 11.6%, P < 0.001). They were also more likely to have an anterior placenta (56.2% vs 51.8%, P < 0.001) and poly/oligohydramnios (0.7% vs 0.4%, P = 0.015 and 3.6% vs 2.1%, P < 0.001, respectively). Induction of labor was more common in the RFM group (33.9% vs 19.7%, P < 0.001), as well as meconium (16.8% vs 15.0%, P = 0.026) and vacuum extractions (10.1% vs 8.0%, P < 0.001). Higher rates of stillbirth and the severe composite neonatal outcome were observed in the RFM group (1.5% vs 0.2%, P < 0.001 and 0.6% vs 0.3%, P = 0.010, respectively). The RFM group was characterized by higher rates of triple nuchal cord (P = 0.015), UC around body or neck (32.2% vs 29.6%, P = 0.010), and true knot (2.3% vs 1.4%, P = 0.002). Multivariable logistic regression found RFMs to be independently associated with triple nuchal cord and with a true cord knot. A sub‐analysis including only cases of stillbirth (n = 127) revealed even higher rates of UC complications: 7% of all stillbirths presented with a true cord knot (20% true knots were found in stillbirths preceded by RFMs vs 6.1% in stillbirth cases without RFMs). Additionally, 33.8% of all stillbirths presented with nuchal cord (40% preceded by RFMs vs 33.3% without RFMs).ConclusionsRFMs are associated with increased risk of UC complications observed at delivery, as well as increased risk of stillbirth and neonatal adverse outcomes.
Loss of Panx1 function in zebrafish alters motor behavior in a lab‐on‐chip model of Parkinson's disease
Authors: Khalili Arezoo , Safarian Nickie , van Wijngaarden Ellen , Zoidl Georg S. , Zoidl Georg R. , Rezai Pouya 
Published: September 2023

AbstractPannexin 1 (Panx1) forms ATP‐permeable membrane channels that play roles in purinergic signaling in the nervous system. A link between Panx1 activity and neurodegenerative disorders including Parkinson's disease (PD) has been suggested, but experimental evidence is limited. Here, a zebrafish model of PD was produced by exposing panx1a+/+ and panx1a−/− zebrafish larvae to 6‐hydroxydopamine (6‐OHDA). Electrical stimulation in a microfluidic chip and quantitative real‐time‐qPCR of zebrafish larvae tested the role of Panx1 in both pathological and normal conditions. After 72‐h treatment with 6‐OHDA, the electric‐induced locomotor activity of 5 days post fertilization (5dpf) panx1a+/+ larvae were reduced, while the stimulus did not affect locomotor activity of age‐matched panx1a−/− larvae. A RT‐qPCR analysis showed an increase in the expression of genes that are functionally related to dopaminergic signaling, like the tyrosine hydroxylase (th2) and the leucine‐rich repeat kinase 2 (lrrk2). Extending the 6‐OHDA treatment duration to 120 h caused a significant reduction in the locomotor response of 7dpf panx1a−/− larvae compared to the untreated panx1a−/− group. The RT‐qPCR data showed a reduced expression of dopaminergic signaling genes in both genotypes. It was concluded that the absence of Panx1a channels compromised dopaminergic signaling in 6‐OHDA‐treated zebrafish larvae and that the increase in the expression of dopaminergic genes was transient, most likely due to a compensatory upregulation. We propose that zebrafish Panx1a models offer opportunities to shed light on PD's physiological and molecular basis. Panx1a might play a role on the progression of PD, and therefore deserves further investigation.
A liquid chromatography‐tandem mass spectrometry method for comprehensive determination of metabolites in the purine pathway of rat plasma and its application in anti‐gout effects of Lycium ruthenicum Murr.
Authors: Jia Qiangqiang , Yang Zufan , Wang Qian , Yang Haishan , Tang Xiaofeng , Zhang Hongyang , Cao Lingling , Zhang Gong 
Published: September 2023

It has been proved that purine metabolites are implicated in various biological syndromes and disorders. Therefore, the realization of panoramic detection of purine metabolites will be of great significance to the pathogenesis of purine metabolic disorders. In the present study, an ultra‐high performance liquid chromatography with tandem mass spectrometry method was developed for the comprehensive quantification of purine metabolites in rat plasma. The 17 purine metabolites were separated and quantified in the short running time of 15 min. The proposed method was strictly validated by applying SeraSub solution as a matrix and proved to be linear (R2 ≥ 0.9944), accurate (the recoveries of all analytes ranged from 85.3% to 103.0%, with relative standard deviation values ≤ 9.3%), and precise (the intra‐ and inter‐day precisions were less than 10.8% and 12.4%, respectively). The method was then successfully applied to the qualification of the endogenous purine metabolites in acute gouty arthritis rats, as well as colchicine and anthocyanin‐intervened rats. Results showed that uric acid, xanthine, hypoxanthine, and xanthine were considered the key factors of acute gouty arthritis. The established method and measurement of purines in rat plasma might help the investigation of the action mechanisms between purine disorders and related diseases.
Biochar/sodium alginate mixed matrix membrane as adsorbent for in‐syringe solid‐phase extraction towards trace nitroimidazoles in water samples prior to ultra‐high‐performance liquid chromatography‐tandem mass spectrometry analysis
Authors: Zhang Hongyu , Zhang Sijia , Li Yingying , Li Lin , Hou Xiaohong 
Published: September 2023

In the present work, the herb (Poria cocos (Schw.) Wolf) residue, as an environmentally friendly and renewable biomass source, was converted into novel biochar. Biochar/sodium alginate mixed matrix membrane was fabricated. On this basis, a biochar/sodium alginate mixed matrix membrane‐based in‐syringe solid‐phase extraction was developed combined with ultra‐high performance liquid chromatography‐tandem mass spectrometry to determine nitroimidazoles in water samples. The factors including times of exaction, type, and volume of elution solvent, and sample solution pH were thoroughly optimized. Then the correlation coefficient was 0.9995–0.9997. The limit of detection of four analytes was between 0.006 and 0.014 ng/mL, and the recovery was between 79.02% and 99.1%. Consequently, the established method would provide a new perspective on monitoring nitroimidazoles in water samples.
High‐performance liquid chromatography‐tandem mass spectrometry method for the analysis of N‐oleoyl glycine and N‐oleoyl alanine in brain and plasma
Authors: Karin Kimberly N. , Mustafa Mohammed A. , Lichtman Aron H. , Poklis Justin L. 
Published: September 2023

Interest has increased in the role of N‐acyl amino acids in a variety of disease states and as potential pharmacotherapies. Recently, N‐oleoyl glycine and N‐oleoyl alanine have shown promise in reducing the rewarding effects of drugs of abuse and alleviating withdrawal signs in rodent models. Previously published methods for the quantitation of these analytes by high‐performance liquid chromatography‐tandem mass spectrometry (HPLC‐MS/MS) in tissue were part of extensive lipidomic panels which may result in limited sensitivity and selectivity and also reported low recovery. Presented is a method for the extraction and HPLC‐MS/MS analysis of N‐oleoyl glycine and N‐oleoyl alanine. The bias and precision of the assay were determined to be within ± 20%. The method was shown to be reliable and robust, with over 90% recovery for the low‐level analytes. Increasing concentrations of N‐oleoyl glycine and N‐oleoyl alanine were quantitated in mouse brain and plasma following exogenous administration. This method was developed to serve to support studies investigating the pharmacokinetics and involvement of N‐oleoyl glycine and N‐oleoyl alanine in drug dependence and other diseases.
Comparison Between Lung Ultrasonography Score in the Emergency Department and Clinical Outcomes of Patients With or With Suspected COVID‐19
Authors: Benchoufi Mehdi , Bokobza Jerôme , Chauvin Anthony , Dion Elisabeth , Baranne Marie‐Laure , Levan Fabien , Gautier Maxime , Cantin Delphine , d'Humières Thomas , Gil‐Jardiné Cédric , Benenati Sylvain , Orbelin Mathieu , Martinez Mikaël , Pierre‐Kahn Nathalie , Diallo Abdourahmane , Vicaut Eric , Bourrier Pierre 
Published: September 2023

ObjectiveChest CT is the reference test for assessing pulmonary injury in suspected or diagnosed COVID‐19 with signs of clinical severity. This study aimed to evaluate the association of a lung ultrasonography score and unfavorable clinical evolution at 28 days.MethodsThe eChoVid is a multicentric study based on routinely collected data that was conducted in 8 emergency units in France; patients were included between March 19, 2020 and April 28, 2020 and underwent lung ultrasonography, a short clinical assessment by 2 emergency physicians blinded to each other's assessment, and chest CT. Lung ultrasonography consisted of scoring lesions from 0 to 3 in 8 chest zones, thus defining a global score (GS) of severity from 0 to 24. The primary outcome was the association of lung damage severity as assessed by the GS at day 0 and patient status at 28 days. Secondary outcomes were comparing the performance between GS and CT scan and the performance between a new trainee physician and an ultrasonography expert in scores.ResultsFor the 328 patients analyzed, the GS showed good performance in predicting clinical worsening at 28 days (area under the receiver operating characteristic curve [AUC] 0.83, sensitivity 84.2%, specificity 76.4%). The GS showed good performance in predicting the CT severity assessment (AUC 0.84, sensitivity 77.2%, specificity 83.7%).ConclusionA lung ultrasonography GS is a simple tool that can be used in the emergency department to predict unfavorable assessment at 28 days in patients with COVID‐19.
When and why signaling frontline employee inexperience can prove to be an asset: Effects on consumer forgiveness for service failure
Authors: Flacandji Michaël , Cusin Julien , Lunardo Renaud 
Published: September 2023

AbstractThe extant literature on service failure focuses mainly on how to recover from such incidents. However, companies can act before a service failure occurs to mitigate its negative effects. Building on signaling theory, we adopt a mixed‐method approach based on five studies using different types of analyses (textual and content analysis, and multivariate analysis) to investigate the effect of signaling frontline employee inexperience on customer responses to service failure due to an error committed by an employee. Five studies provide evidence that highlighting inexperience—either informally (through a conversation) or formally (through an in‐training badge)—can act as a signal that prompts customers to be more forgiving toward frontline employees, and such consumer forgiveness then serves as an underlying mechanism to explain repatronage intention. This research also tests and explores the boundary conditions for the effectiveness of the inexperience signal. Our findings have various implications for professionals showing how useful it can be to signal the inexperience of a frontline employee who makes an error that leads to a service failure to be given a second chance, and how certain precautions should be taken to avoid the pitfalls of such a signaling strategy.
Supercharged deep inferior epigastric perforator flap for reconstruction of soft tissue defect after excision of giant invasive squamous cell carcinoma of the thigh in a refractory diabetic with Pseudomonas aeruginosa infection
Authors: Malkoc Aldin , Landau Mark Jonathan , Hodgkin Savannah , Leong Darren Sze Mynn , Johna Samir Dankha , Chang Walter Ting‐Yu 
Published: September 2023

AbstractPatients with large defects after oncologic surgery often require enhanced surgical planning to optimize reconstructive outcomes. As such, medically complex patients require innovative solutions when utilizing abdominal flaps due to concern for ischemia of the distal tissue. Vascular augmentations, such as supercharging or turbocharging, serve to increase perfusion in these medical complex patients to ensure flap survival. In this report, we highlight the use of a supercharged bilateral pedicled deep inferior epigastric perforator (DIEP) flap in a patient with a 231 cm2 thigh defect in the setting of uncontrolled diabetes. A 57‐year‐old male with poorly‐controlled diabetes (blood sugar prior to surgery 510 mg/dL) and iron deficiency anemia presented with a two‐year history of a large nonmetastatic squamous cell carcinoma (SCC) measuring 19 × 9 cm2 on the right thigh. Positron emission tomography/computed tomography and biopsies of the right retroperitoneal and inguinal lymph nodes diagnosed the mass as Stage 3 localized SCC. After excision, we performed immediate reconstruction of the resultant defect with a supercharged bilateral pedicled DIEP flap. The flap was pedicled on the ipsilateral DIEP and the contralateral perforator was anastomosed to the descending branch of the lateral circumflex femoral artery (DLCFA) at the inferior aspect of the defect. A venous coupler was used for the veins and the arteries were hand‐sewn in end‐to‐end fashion. The supercharged bilateral pedicled DIEP flap was utilized for enhanced augmented perfusion to the distal edge of the pedicled flap in a high‐risk patient. The patient's clinical course was complicated by a Pseudomonas infection of a small hematoma requiring operative washout and debridement of necrotic fat. However, the flap survived and covered the defect completely. The patient required outpatient antibiotics for the Pseudomonas infection which resolved completely without further need for operative intervention. At 6‐month follow up, the reconstruction was stable with no tumor recurrence on clinical exam. Our results suggest that a supercharged pedicled DIEP flap may be a viable option for large defects of the thigh and can may be utilized in medically complex patients with poor capacity for wound healing.
The role of beliefs in teacher candidates' development of self‐regulated learning promoting practices
Authors: Brenner Charlotte A. 
Published: September 2023

AbstractSelf‐regulated learning (SRL)‐promoting practices enhance students' positive academic, social, and emotional development. While effective, these practices are complex and often difficult for teacher candidates (TCs) to learn and implement. This theoretical review presents the benefits and challenges of SRL‐promoting practices and examines how TCs' beliefs about SRL are implicated in their development and implementation of these practices. Conditions within teacher education programs that attend to TCs' beliefs about these practices are examined and suggestions are provided for further research in the area of TCs' beliefs and their development of teaching practices that promote SRL.
Co‐Ni/MOF‐74 catalyst packed‐bed DBD plasma for ammonia synthesis
Authors: Liu Yang , Xu Xiaofang , Song Qinlong , Guo Zihan , Wu Xuan , Chen Chongchong , Chen Qiang , Zhang Haibao 
Published: September 2023

AbstractNonthermal plasma (NTP) provides a potential and sustainable route for the synthesis of ammonia. In this work, a Co–Ni/MOF‐74 catalyst was developed to synthesize ammonia from N2 and H2 in a dielectric barrier discharge (DBD) plasma at low temperature and atmospheric pressure. Co–Ni/MOF‐74 showed the highest ammonia synthesis rate up to 2608.70 μmol g−1 h−1 at 200°C, with V(N2):V(H2) ratio of 1:1 and specific energy input of 33.27 kJ L−1. The catalytic activity was increased by 19.57% for Co–Ni/MCM‐41 and 375% for Co‐Ni/Al2O3, respectively. It was observed that the average electric field (E) and power efficiency were enhanced while adding Co–Ni/MOF‐74 to the reaction system.
Can socialized pest control service reduce the intensity of pesticide use? Evidence from rice farmers in China
Authors: Yan Aqian , Luo Xiaofeng , Tang Lin , Huang Yanzhong , Du Sanxia 
Published: September 2023

AbstractBACKGROUNDAlthough a great deal of research has examined the impact of socialized pest control service, few studies have discussed the relationship between socialized pest control service and pesticide use intensity. In particular, the literature ignores the impact of advanced application technologies (drone sprayers) on the intensity of pesticide use by farmers.RESULTSBased on a survey of 1185 rice growers in Hubei Province, China, this study found that 64.13% of the sample farmers used pesticides more than three times in one rice season. Importantly, socialized pest control services have a significant negative effect on the pesticide use intensity of farmers. Compared to the sample that did not purchase the service, farmers who purchased socialized pest control services demonstrated 9.30% less pesticide intensity. Further, there was a significant difference among farmers using different application devices on pesticide use intensity. Compared to the sample using ground backpack sprayers, farmers using drone sprayers used 12.40% less pesticide intensity.CONCLUSIONThis study found that the frequency of pesticide use by farmers during rice cultivation was generally high. Socialized pest control services have played a positive role in reducing the intensity of pesticide use, especially with the more obvious pesticide reduction effect of the adoption of drone sprayers. Therefore, improving socialized pest control services and promoting advanced equipment such as drone sprayers may be an important way to reduce the use of pesticides in China. © 2023 Society of Chemical Industry.
A Sensitive Fluorescence Probe for the Trace Detection of Fe(III) Based on a Post‐Synthesis‐Modified Copper‐Based Metal‐Organic Framework
Authors: Pamei Mala , Achumi Abel G , Puzari Amrit 
Published: September 2023

AbstractThis work presents the generation of a post‐synthetically modified Metal‐Organic Framework (MOF), denoted as Cu‐BDC‐NH2‐DHB, achieved through a Schiff‐base reaction by converting the pendant amino group in pristine Cu‐BDC‐NH2 MOF to an imine group using 3,4‐dihydroxybenzaldehyde (DHB). The resulting material exhibited exceptional luminescence and fluorescence stability in water, prompting investigation into its potential as a metal sensor. Fluorescence tests revealed that Cu‐BDC‐NH2‐DHB could be transformed into a highly selective and sensitive sensor for detecting Fe3+ ions amid co‐interfering metal ions, with a remarkable detection limit of 3.08 μM. Furthermore, the results demonstrated that Fe3+ induced a rapid and strong quenching effect, with a reaction time measured in seconds. This research provides a promising technique for the facile and immediate detection of Fe3+ ions in practical applications.
Anti‐Epileptic Drug‐Lipid Conjugates for Delivery to the Brain: In Silico ADMET Prediction, Molecular Docking and Molecular Dynamics Simulations
Authors: Athalye Mansi , Teli Divya , Sharma Abhilasha , Patel Mrunali 
Published: September 2023

AbstractNeurological disease epilepsy has unfortunately become widespread, affecting around 50 million individuals worldwide. Levetiracetam (LVM) is a newer‐generation drug but its hydrophilic nature restricts its BBB (blood‐brain barrier) permeability. This results in increased dose, dosing frequency, and side effects. Therefore, different lipid‐drug conjugates (LDCs) were studied to identify the compound capable of BBB permeation. The binding potential of LDCs with human brain fatty‐acid binding protein (HBFABP) (PDB id: 1FDQ) was determined by molecular docking through extra‐precision (XP) algorithm of Maestro. In simulations, OPLS3e force field was applied. The ADMET prediction was performed by QikProp and pkCSM web tool. The selected compounds were investigated for LDC‐BFABP complex stability through molecular dynamics (MD) study. All compounds indicated good pharmacokinetic profiles. The LVM‐palmitic acid and LVM‐stearic acid conjugates indicated higher docking scores and greater stability than LVM alone. Thus, they can be selected as potential molecules for further drug development to obtain clinically useful LDC for treatment of CNS disorder.
Guiding the Path to Healing: CuO2‐Laden Nanocomposite Membrane for Diabetic Wound Treatment
Authors: Qi Lin , Huang Yong , Sun Dan , Liu Zheng , Jiang Yulin , Liu Jiangshan , Wang Jing , Liu Limin , Feng Ganjun , Li Yubao , Zhang Li 
Published: September 2023

AbstractDiabetic chronic wounds pose significant clinical challenges due to their characteristic features of impaired extracellular matrix (ECM) function, diminished angiogenesis, chronic inflammation, and increased susceptibility to infection. To tackle these challenges and provide a comprehensive therapeutic approach for diabetic wounds, the first coaxial electrospun nanocomposite membrane is developed that incorporates multifunctional copper peroxide nanoparticles (n‐CuO2). The membrane's nanofiber possesses a unique “core/sheath” structure consisting of n‐CuO2+PVP (Polyvinylpyrrolidone)/PCL (Polycaprolactone) composite sheath and a PCL core. When exposed to the wound's moist environment, PVP within the sheath gradually disintegrates, releasing the embedded n‐CuO2. Under a weakly acidic microenvironment (typically diabetic and infected wounds), n‐CuO2 decomposes to release H2O2 and Cu2+ ions and subsequently produce ·OH through chemodynamic reactions. This enables the anti‐bacterial activity mediated by reactive oxygen species (ROS), suppressing the inflammation while enhancing angiogenesis. At the same time, the dissolution of PVP unveils unique nano‐grooved surface patterns on the nanofibers, providing desirable cell‐guiding function required for accelerated skin regeneration. Through meticulous material selection and design, this study pioneers the development of functional nanocomposites for multi‐modal wound therapy, which holds great promise in guiding the path to healing for diabetic wounds.