bluuebunny/crossref_metadata_2025_split huggingface dataset:
Loss control case reports to OPE25 on FinTech for SOX ratio to consider for solvency and insurance underwriting
Authors: Koeplin John P. , Lélé Pascal 
Published: February 2023

AbstractWith the OPE25 we now have a 3rd ratio for the capital structure: Economic Capital/Incentivized Pay. The SOX ratio is the financial instrument for internal audit, solvency monitoring by the investor and banking supervision for OPE—Calculation of RWA for operational risk, new version in force on January 1, 2023. It is part of the entity's process to meet the three minimum conditions required by BCBS for the use of the standardized approach: (a) Its board of directors and senior management, as appropriate, are actively involved in the oversight of the operational risk management framework; (b) It has an operational risk management system that is conceptually sound and is implemented with integrity; and (c) It has sufficient resources in the use of the approach in the major business lines as well as the control and audit areas. Equity corresponds to the means made available to a bank by its shareholders or other investors, as well as to the profits it has made, and which have not been distributed. Economic Capital (EC) belongs to this last category of means. The OPE30 in force so far based on the mathematical approach (statistics and probabilities), will expire on December 31, 2022.
Population Pharmacokinetics, Exposure–Safety, and Probability of Target Attainment Analyses for Isavuconazole in Japanese Patients With Deep‐Seated Mycoses
Authors: Shirae Shinichiro , Tsuruya Yuri , Kozaki Tomohito , Mizuhata Junnosuke , Ose Atsushi 
Published: February 2023

AbstractIsavuconazonium sulfate is the water‐soluble prodrug of the novel, broad‐spectrum, triazole antifungal agent isavuconazole. Its pharmacokinetics (PK) and exposure–response relationship have been well investigated, but not in a Japanese patient population. The objectives of this analysis were to (1) develop a population PK model for Japanese patients with deep‐seated mycoses and healthy subjects, and to identify significant covariates; (2) determine the probability of PK‐pharmacodynamic (PK‐PD) target attainment in Japanese patients by a clinical dosing regimen; and (3) evaluate the exposure–safety relationship of isavuconazole in Japanese patients. Data from 2 phase 1 studies and 1 phase 3 study in Japanese patients were pooled to develop the population PK model using NONMEM. The PK of isavuconazole in Japanese patients was best described as a 2‐compartment model with a Weibull absorption function and first‐order elimination. The identified covariates on clearance were creatinine clearance and lean body mass. The probability of target attainment showed that >90% of simulated Japanese patients would achieve the PK‐PD target, an exposure index corresponding to 50% survival of nonneutropenic infected mice, with minimal inhibitory concentration values of ≤1 mg/L according to Clinical and Laboratory Standards Institute methodology and of ≤2 mg/L according to European Committee on Antimicrobial Susceptibility Testing methodology by the clinical dosing regimen. No apparent relationships were found for any of the exposure parameters of isavuconazole with any assessed safety end points in Japanese patients. Taken together, the clinical dosing regimen is appropriate for the treatment of Japanese patients with deep‐seated mycoses.
Improving prenatal detection of abdominal supraumbilical anomalies: The sonographic examination of fetal anechoic spaces of upper abdomen revisited
Authors: Sepulveda Waldo , Wong Amy E. , Ranzini Angela C. 
Published: February 2023

AbstractVisualization of the axial plane of the fetal abdomen is mandatory to obtain abdominal biometry in the assessment of fetal growth in the second and third trimesters. The main anatomic landmarks that must be identified in this view include the fetal stomach and the intrahepatic portion of the umbilical vein, which are easily identifiable as they appear anechoic on ultrasound. The gallbladder is the other prominent anechoic structure in this plane. Focused study of the morphological characteristics of, and spatial relationship among, these three anechoic spaces is a simple technique to detect anomalies involving fetal upper abdominal organs. In this review, the sonographic features of those conditions that can be detected using this technique, which was termed the Fetal Examination of the Anechoic Spaces of upper abdomen Technique (FEAST), are classified and illustrated.
Delineating early developmental pathways to ADHD: Setting an international research agenda
Authors: Miller Meghan , Arnett Anne B. , Shephard Elizabeth , Charman Tony , Gustafsson Hanna C. , Joseph Heather M. , Karalunas Sarah , Nigg Joel T. , Polanczyk Guilherme V. , Sullivan Elinor L. , Jones Emily J. H. 
Published: February 2023

AbstractBackgroundAttention‐deficit/hyperactivity disorder (ADHD) is a prevalent, impairing, and highly heritable condition typically diagnosed in middle childhood. However, it is now recognized that symptoms emerge much earlier in development. Research focused on understanding—using multiple units of analysis—the cascade of early‐life (i.e., prenatal‐infant‐toddler) developmental changes that will later emerge as ADHD has the potential to transform early identification, prevention, and intervention. To this end, we introduce the recently established Early ADHD Consortium, an international network of investigators engaged in prospective, longitudinal studies of risk for ADHD beginning early in life, conducted within a developmental framework, and which incorporate multimethod approaches. This network seeks to harmonize measures and methodological approaches to increase the potential for data sharing and subsequent impact.MethodsThis perspective paper highlights the importance of investigating pre‐diagnostic markers of ADHD, and potential models and mechanisms of ADHD risk and development, with the long‐term objective of facilitating development of preemptive interventions that will minimize the impact of ADHD symptoms on everyday functioning and maximize health and developmental outcomes.ResultsWe selectively describe key challenges and questions for this field related to theoretical models and developmental mechanisms in ADHD and recommend next steps for the science, including methodological, measurement, and study design considerations. We then describe potential implications for preemptive intervention development. We conclude by considering other issues including ethical concerns and the critical value of incorporating stakeholder input.ConclusionsIt is hoped that this perspective puts forth a research agenda that will enhance collaborative efforts and accelerate progress in understanding developmental mechanisms and the early ADHD phenotype, with implications for early intervention enhancement of healthy development for infants, young children, and their families.
Mutation pattern of cancer suppressor p53 gene in factory workers exposed to polypropylene and impact on their reproductive hormones
Authors: Razak Suhail , Asharf Naeem Mahmood , Abbas Hira , Shaheen Ghazala , Ahmad Waqar , Afsar Tayyaba , Almajwal Ali , Shabbir Maria , Shafique Huma , Jahan Sarwat 
Published: February 2023

AbstractBackgroundPolypropylene is a thermoplastic polymer playing the role of an endocrine disruptor that interferes with the union, emission, transport or elimination of normal hormones. Epidemiological information indicated the relation of endocrine‐disturbing chemicals with prostate cancer, testis tumor and diminished fertility. p53 is a key tumor silencer gene. The present study aimed to evaluate luteinizing hormone (LH) and follicle‐stimulating hormone (FSH) levels and the risk of p53 mutations as a result of exposure to polypropylene in non‐tumorous adult male factory workers.MethodsIn total, 150 (controls = 35, workers = 115) subjects were recruited. Groups were maintained according to the tenure of exposure G1 (1–5 years), G2 (6–10 years), G3 (11–15 years) and G4 (16–20 years). Concentrations of LH and FSH were determined through an enzyme‐linked immunosorbent assay. Genotyping analysis was performed by polymerase chain reaction based gel electrophoresis followed by DNA sequencing. The structural and functional impact of the mutation on the p53 structure was evaluated using 50‐ns molecular dynamics (MD) simulations and protein‐DNA docking.ResultsMean plasma LH levels were significantly decreased in G1 (p > 0.05) as well as the G2, G3 and G4 (p > 0.001) groups. Similarly, FSH levels were significant decrease in G1 (p > 0.05), G2 (p > 0.01), G3 (p > 0.001) and G4 (p > 0.001) compared to the control group. Sequencing results found three variants i.e. g.13450 T>G, g.13430C>T and g.13737G>A. One of them was predicted to be disease‐causing others are polymorphisms. MD simulation of missense mutation R273H showed no structural impact on the protein structure in MD simulation, but it resulted in weaker binding of p53 with the DNA that might lower the gene expression of cell cycle regulatory proteins.ConclusionsThese findings predict decreased fertility and risk of malignancies in the future. The spectrum of p53 mutations as a result of polypropylene exposure in the Pakistani population has not been investigated before. Further studies and meta‐analyses are required to elucidate the role of different plasticizers in reproduction and cancer‐causing risk factors in a larger population.
Field experiments in operations management
Authors: Gao Yang , Li Meng , Sun Shujing 
Published: February 2023

AbstractWhile the field experiment is a powerful and well‐established method to investigate causal relationships, operations management (OM) has embraced this methodology only in recent years. This paper provides a comprehensive review of the existing OM literature leveraging field experiments. It also serves as a one‐stop guide for future application of field experiments in the OM area. We start by recapping the characteristics that distinguish field experiments from other common types of experiments and organizing the relevant OM studies by topic. Corresponding to the commonly overlooked issues in field experiment‐based OM studies, we then provide a detailed roadmap, ranging from experimental design and implementation to post‐experiment analysis. We further outline the methodological and practical issues as well as corresponding solutions when applying field experiments. We conclude by identifying future research directions from an OM perspective.
A novel radial orientation treatment of nematic liquid crystals using magnetic field lines with permanent magnet and applying the assisted electric field
Authors: Takahashi Taiju , Kudoh Yukihiro , Saito Yuichi , Aoyagi Yoshihiro 
Published: February 2023

AbstractRecently, there has been considerable research on optical devices, such as liquid crystal (LC) lenses and special optical plates, using LCs. In such devices, relatively small LC cells are frequently used, or unique LC orientations are required. As an LC orientation process, we focused on the LC director's orientation induced by the magnetic force line distribution of a small neodymium magnet. We propose a simple method for obtaining radial orientation, which is rather difficult to obtain using the ordinary rubbing method. The initial orientation in the LC cell is a vertical orientation cell with almost zero azimuth anchoring. With the proposed method, the reorientation process is performed with an assisting electric field and a small permanent magnet, unlike the conventional magnetic field orientation process that requires a large electromagnet. Furthermore, a polymer stabilization treatment is used to fix the obtained radial orientation pattern in the LC cell. After the treatment, the applying voltage can control the tilt angle of the director in weak polymer treatment, and a completely fixed orientation pattern can be obtained that in strong.
The role of symptom accommodation in trauma‐focused treatment engagement and response
Authors: Howard Kristen P. , Spoont Michele R. , Polusny Melissa A. , Eftekhari Afsoon , Rosen Craig S. , Meis Laura A. 
Published: February 2023

AbstractAlthough trauma‐focused treatments (TFTs) are generally effective, not all patients improve. Symptom accommodation (i.e., altering one's behavior in response to another's symptoms) by loved ones may be particularly relevant to TFT treatment response and engagement. We examined the role of symptom accommodation by support persons (SPs) in veterans’ PTSD treatment response, including the mediating role of treatment engagement and the moderating role of relationship strain. Veterans engaging in prolonged exposure or cognitive processing therapy and a loved one (N = 172 dyads) were sampled at two time points approximately four months apart. Measures of treatment engagement (i.e., highest session completed from the treatment protocol and homework completion) were obtained from hospital records. We found that relationship strain moderated the effect of symptom accommodation on treatment response, ∆R2 = .02. Specifically, Time 1 (T1) accommodation predicted poorer treatment response (i.e., Time 2 [T2] PTSD symptom severity, controlling for T1 symptoms) among veterans who reported below‐average relationship strain only. Additionally, symptom accommodation was indirectly related to treatment response such that T1 accommodation predicted higher T2 PTSD symptom severity specifically through reduced homework completion, β = .01. The findings suggest that attending to accommodating behaviors of veterans’ supportive partners may be an important way to boost both engagement in and response to TFTs for PTSD.
Detailed tribological analysis of compressor lubricants used in electrical technology
Authors: Vasco Marina Cardozo , Dill Laís Pastre , Moreira Heloisa Colli , Wollmann Daniela , Wilhelm Helena , Zanin Thiago L. , Pintaude Giuseppe 
Published: February 2023

AbstractThis work presents a comprehensive tribological analysis comparing the performance of two types of lubricants—a synthetic and a natural ester—used in industrial reciprocating air compressors. A comprehensive tribological analysis comparing the performance of two types of lubricants—synthetic and natural esters—used in industrial reciprocating air compressors were carried out using surface characterisation methods and lubricant analyses. The formed and detected tribo‐films were not efficient to avoid the wear observed on the cylinders, although they may have been to avoid the wear on the rings. Regarding the lubricant analyses, particle analysis showed that none of the lubricants favoured solid particle leaching to a greater extent. A biolubricant such as the one employed in this study would be suitable for replacing a mineral lubricant in situations like the ones observed in this work.
The implications of the carbon tax on the vehicle remanufacturing industry in the complex competitive environment
Authors: Wang Yue , Wang Zhe , Gong Yande , Li Bangyi , Cheng Yongbo 
Published: February 2023

AbstractUnder the carbon tax policy, the vehicle remanufacturing has become popular, which threatens the new vehicle market. Facing the complicated competitive environment, the automobile manufacturer always adjusts product modular design to deal with the challenges from the internal and external remanufacturing. Currently, considering the impacts of the complicated market competitions and product modular design on the enterprise's operation management, how the carbon tax policy affects the vehicle remanufacturing is still uncertain. Thus, we construct a duopoly remanufacturing competition model consisting of an automobile manufacturer and remanufacturer with the aim of maximizing profit and determine the optimal product modular design, production, and remanufacturing decisions as well as profits. Then, we explore the impacts of the carbon tax on the vehicle remanufacturing supply chain from the perspectives of the economic, environment, and consumer surplus. The results show that the carbon tax is always disadvantageous to automobile manufacturer's profit but may benefit the automobile remanufacturer's profit. Contrary to the intuition, improving the carbon tax is not always conducive to the environment and harmful to the consumer.
Future time perspective and academic procrastination among nursing students: The mediating role of mindfulness
Authors: Li Shuang , Su Jingwen , Zhao Di , Wang Juan , Wang Gongchao 
Published: February 2023

AbstractAimTo explore the relationship between university nursing students' academic procrastination, mindfulness, and future time perspective.DesignA cross‐sectional study.MethodsA total of 343 university nursing students recruited from eight provinces in China have reported procrastination characteristics through fulfilling an online website link. The main instruments involved Mindfulness Attention Awareness Scale (MAAS), Zimbardo Time Perspective Scale, and Procrastination Assessment Scale (PASS).ResultsParticipants who self‐assessed higher frequency and degree of academic procrastination tended to possess lower future time consciousness, and lower mindfulness. Mindfulness served as a mediation effect between future time perspective and academic procrastination. The study indicates that weakening an individual's procrastination can be alleviated through future time awareness and mindfulness. Concentrating on influencing factors, strengthening nursing student's future time perspective, and practicing mindfulness training could assist educators to decrease students' procrastination intentions and behaviours.
Longitudinal body weight dynamics in relation to cognitive decline over two decades: A prospective cohort study
Authors: Zhou Tianjing , Chen Hui , Huang Yuhui , Wang Binghan , Zheng Yan , Wang Liang , Rong Shuang , Ma Yuan , Yuan Changzheng 
Published: February 2023

AbstractObjectiveThe aim of this study was to investigate the associations of body weight change (BWC) and body weight variability (BWV) with changes in cognitive function.MethodsIn 10,340 Health and Retirement Study participants (mean age: 68.0 years), body weight was reported biennially from 1993/1994 to 2016, and cognitive function was measured biennially from 1998 to 2016. We calculated BWC and BWV as the slope and root‐mean‐square error by regressing body weight on time for each individual. BWC was categorized by quintiles (Q): stable weight (Q2 to Q4), weight loss (Q1), and weight gain (Q5). BWV was categorized by tertiles. We used linear mixed regression models to assess associations with cognitive change.ResultsCompared with stable weight (median: 0 kg/y), weight loss (median: −1.3 kg/y) predicted faster cognitive decline as demonstrated by mean difference of −0.023 (95% CI: −0.027 to −0.019) in cognitive change z score per year, whereas weight gain (median: 1 kg/y) was related to slower cognitive decline (β = 0.006; 95% CI: 0.003 to 0.009). Larger BWV was also associated with faster cognitive decline (β comparing the top with bottom tertile = −0.003; 95% CI: −0.006 to −0.0002). Similar associations were observed for episodic and working memory.ConclusionsWeight loss and large BWV over a long time independently predicted faster cognitive decline in middle‐aged and older adults, underscoring the importance of long‐term dynamic body weight monitoring.
Non‐OH‐driven liquid‐phase chemistry in water microdroplets
Authors: Nayak Gaurav , Wang Jianan , Li Rui , Aranzales Diana , Thagard Selma Mededovic , Bruggeman Peter J. 
Published: February 2023

AbstractWater microdroplets containing organic and fluorinated compounds, such as formate, perfluorooctanoic acid (PFOA) and triflic acid, were exposed to a radiofrequency glow discharge plasma with a droplet residence time on the order of milliseconds. Triflic acid remained unaffected by any plasma condition while >75% decomposition of formate and PFOA could be achieved. In situ hydroxyl (OH)‐laser‐induced fluorescence measurements near the droplets confirmed that the conversion was independent of the OH flux to the droplet. A series of control experiments suggest that the contribution of vacuum UV photons in such decomposition of aqueous compounds can be significant for He and He + 17% Ar plasmas and can also explain unexpected decomposition trends as a function of droplet residence time in the plasma.
Distinguishing features of fold‐switching proteins
Authors: Chakravarty Devlina , Schafer Joseph W. , Porter Lauren L. 
Published: February 2023

AbstractThough many folded proteins assume one stable structure that performs one function, a small‐but‐increasing number remodel their secondary and tertiary structures and change their functions in response to cellular stimuli. These fold‐switching proteins regulate biological processes and are associated with autoimmune dysfunction, severe acute respiratory syndrome coronavirus‐2 infection, and more. Despite their biological importance, it is difficult to computationally predict fold switching. With the aim of advancing computational prediction and experimental characterization of fold switchers, this review discusses several features that distinguish fold‐switching proteins from their single‐fold and intrinsically disordered counterparts. First, the isolated structures of fold switchers are less stable and more heterogeneous than single folders but more stable and less heterogeneous than intrinsically disordered proteins (IDPs). Second, the sequences of single fold, fold switching, and intrinsically disordered proteins can evolve at distinct rates. Third, proteins from these three classes are best predicted using different computational techniques. Finally, late‐breaking results suggest that single folders, fold switchers, and IDPs have distinct patterns of residue–residue coevolution. The review closes by discussing high‐throughput and medium‐throughput experimental approaches that might be used to identify new fold‐switching proteins.
Plasticizers' effect on pH indicator film based on starch and red grape skin extract for monitoring fish freshness
Authors: Góes Mariana Moraes , Simões Bruno Matheus , Yamashita Fabio , Mali de Oliveira Suzana , de Carvalho Gizilene Maria 
Published: February 2023

AbstractThis work aimed to develop a novel colorimetric indicator film from cassava starch, isomalt and glycerol with 20% wt.% of grape skin extract (GSE) by casting to be used as an indicator of fish freshness. The plasticizers were used in the concentration of 33% at five levels: 100/0, 70/30, 60/40, 50/50 and 0/100 (%w/w isomalt/glycerol). Fourier transform infrared spectroscopy (FTIR), X‐ray diffraction (XRD) and RGB colour analysis showed the homogenous distribution of GSE in the starch matrix. The presence of GSE reduces the thermal stability, k1 value, solubility, swelling values and the %E and increases the tensile strength (TS), revealing its plasticizing potential action in the presence of isomalt. The influence of pH on the colours of the film containing GSE and its indicator activity were evaluated. The results showed that the film produced operates in a wide pH range, being an excellent candidate as an indicator for monitoring fish freshness.