bluuebunny/crossref_metadata_2025_split huggingface dataset:
Distribution and management of Fallopia japonica in riparian biotopes in Slovakia and Austria
Authors: Vaseková B. , Majorošová M. , Belčáková I. , Slobodník B. 
Published: February 2023

Globally, invasive species represent a serious threat to biodiversity and to the ecosystem. As an undesirable part of riparian ecosystems, invasive plants form continuous growths on the banks of watercourses. One of the biggest problems at river bank sites is Japanese knotweed, Fallopia japonica (Houtt.) Ronse Decr, which is an extremely invasive and aggressive weed. The topic of the interaction of flow and invasive plant species in shore stands is rich and presents a wide range of possibilities for research. The presented paper brings the results of our studies on the invasions of F. japonica in chosen riparian vegetation sites in Austria and Slovakia from 2011–2020 (36 stands). Our research was aimed at the survey on the changes in the distribution (spread) of F. japonica at the selected river sites; assessment of the impact of the watercourse regime on the spread of F. japonica; monitoring of the population growth dynamics of F. japonica and assessment of possibilities for effective eradication of F. japonica in context of the riparian vegetation management. We used standard techniques of field survey, mapping, flow modeling/simulation, and laboratory experiments. Our research results showed that water streams are not primary invasion starters until there is a flood. As long as flooding does not exceed the critical speed of the water stream, there is no direct damage to the invasive plant. The water body can be a secondary trigger for plant invasion at normal speeds. In addition, F. japonica reproduction ability directly conditions its population dynamic growth. We can report that selective invasion removal adapted to local conditions can be most suitable and beneficial for municipalities.
Apuntando al trabajo con las emociones desde la formación en Trabajo Social con sujetos y familias
Authors: Castrillón Agudelo Natalia Andrea , Martínez Gómez Lina María 
Published: February 2023

El artículo expone el lugar central de las emociones en la propuesta educativa de Trabajo Social de la universidad del Quindío, específicamente en los espacios académicos Trabajo Social Contemporáneo II y III, destinados a la formación para la praxis profesional con sujetos y familias. Se plantean los aportes de las pioneras que dan soporte a esta apuesta formativa, y las estrategias de enseñanza-aprendizaje implementadas para concretarla en el abordaje de las dimensiones de la disciplina-profesión, desde un compromiso con la reflexividad de las(os) estudiantes de sí mismas(os) como sujetos, con emociones construidas y transformadas en interacciones significativas, como las familiares.
Solar panels problem after end-of-life and waste management (SWOT analysis for the global directives of PV's waste management)
Authors: Ghaleb Al-Aqqad Ali Omar , Menyhart Jozsef 
Published: February 2023

AbstractPhotovoltaic energy is a well-known term nowadays, and with the continuous increase in PV demand, it has become necessary to consider the other sides that may affect the success of it, which is considered one of the real effects on the environment. The PV waste has started to create a large issue with the absence of administrative procedures in many countries. Despite the estimated life of photovoltaic panels being between 20 and 30 years, many units have already started to stop working. However, research indicates the total cost of new materials to manufacture a PV panel is around USD 90 per square meter, compared to USD 13.62 for the costs of recycling a PV module. The regulations disclosed that the problem of EoL for PV modules and their management is still not considered an issue in many countries. Therefore, SWOT analysis was used to evaluate the EoL management of waste PV modules in three regions in Washington, California, and the European Union's WEEE Directive. This study presents recommendations to strengthen regulations to manage the problems of the EoL waste, and open the way for countries and the private sector to realize the responsibility that may affect the environment.
Can the transection plane be optimized in pancreatic resections?
Authors: Szuák András , Korom Csaba , Németh Károly , Nemeskéri Ágnes , Harsányi László 
Published: February 2023

AbstractPurposeAccording to current protocol, the separation of pancreatic head and body is performed at the level of superior mesenteric vein (SMV). Previous data indicate that the resection plane should be modified in portal annular pancreas. We presumed that the optimal line of pancreatic resections could also be different in other cases. Our aim is to simulate pancreatic resections in different planes and find the optimal resection line with the minimum number of cut vessels.Main methods25 abdominal vascular corrosion casts were prepared, the aorta and the portal vein were cannulated. CT scans were taken on the casts, and specific planes were reconstructed simulating different resection lines. The total amount of cross sections of vessels were calculated in the different planes.ResultsIn our series, the optimal plane is the SMV in 11/25, 2 cm left in 10/25, 1 cm left in 4/25, 1 cm right in 1/25 and 2 cm right in none of our cases. The group of left sided extension contain more than half of the cases. With left sided resections, the cut surface of the vessels may be lowered to even 29% compared to the SMV plane.ConclusionOur study revealed that pancreatic resections should be extended to the left side of the SMV in more than half of our cases. Therefore, the resection plane should be determined by preoperative imaging methods. Using DICOM viewer with multiplanar reconstruction, the resection planes can be simulated in clinical practice, which would reduce the risk of postoperative bleeding.
Breviscapine restores sevoflurane-induced cognitive dysfunction by activating the PI3K/Akt pathway and inhibiting NF-κB
Authors: Mao Qingju , Cheng Ke , Zhang Zhen 
Published: February 2023

Postoperative cognitive dysfunction (POCD) is featured by cognitive impairments in patients with high morbidity and mortality. Sevoflurane (SEV) is one of the main drugs used to maintain clinical general anesthesia and has been found to cause cognitive dysfunction. Breviscapine has various pharmacological effects. However, the effects of breviscapine on sevoflurane-induced cognitive dysfunction is unclear. The sevoflurane-induced cognitive dysfunction rat model was established. Morris water maze task was conducted to detect time in target quadrant, number of platform crossings, and the distance covered in the quadrant. Hematoxylin and eosin (H&E) staining was used to examine cell morphology. Cell apoptosis was analyzed through terminal deoxynucleotidyl transferase (TdT)-mediated dUTP Nick-End Labeling (TUNEL) staining. Quantitative reverse transcription polymerase chain reaction (qRT-PCR) detected the messenger RNA (mRNA) levels. Western blot assay was conducted to measure the protein level. Enzyme-linked immunosorbent serologic assay examined tumor necrosis factor-α, interleukin (IL)-6, IL-1β, malondialdehyde, superoxide dismutase, plasma glutathione peroxidase, and catalase levels. Breviscapine improved sevoflurane-induced cognitive dysfunctioning in rats. Breviscapine could play a suppressive role in apoptosis in the brain tissues of sevoflurane-induced rats. Further functional analysis showed that sevoflurane increased inflammation and oxidative stress in the brain tissues of sevoflurane-induced rats whereas breviscapine exerted apposite effects on sevoflurane-induced inflammation and oxidative stress. Additionally, we demonstrated that breviscapine promoted sevoflurane-induced phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) (PI3K/Akt) pathway and inhibited sevoflurane-induced nuclear factor kappa B (NF-κB) pathway in the brain tissues of rats. These results indicate that breviscapine could improve sevoflurane-induced cognitive dysfunction through activating the PI3K/Akt pathway and suppressing NF-κB pathway, which provides a therapeutic method for patients with sevoflurane-induced cognitive dysfunction.
DFT investigation of pyramidal Au\(_{9}\)M\(^{2+}\) and Au\(_{19}\)M (M = Sc-Ni): Similarities and Differences of Structural Evolution, Electronic and Magnetic Properties
Authors: Lan Ngo Thi , Mai Nguyen Thi , Dang Nguyen Van , Tung Nguyen Thanh 
Published: February 2023

Au102+ and Au20 pyramids, whose stability and inertness are comparable to those of carbon fullerene C60, are considered as important landmarks in the long-history investigation of gold nanoclusters. Numerous experimental and theoretical studies on doping Au102+ and Au20 with transition metal atoms have been carried out for specific properties that can be used as advanced materials in nanotechnology applications. In this work, we discussed the similarities and differences between the structural, stability, and electronic properties of Au9M2+ and Au19M (M = Sc-Ni) clusters using density functional theory calculations. It is found that except for the preferred dopant site, the structural evolution of Au9M2+ cluster resembles that of Au19M in general. Although the V dopant seems to be the important ingredient for the structural transformation in both species, it is remarkable that the transformation appears stronger in Au19V compared with Au9V2+. The calculated average binding energies are utilized to identify their relative stable patterns. Depending on the 3d transition metal atom dopant, the spin magnetic moments of Au9M2+ and Au19­M clusters vary from 0 to 5 μB, reaching the highest value with the Cr-doped species. We show that both Au9Cr2+ and Au19Cr have similarities in the electronic structures and are potential magnetic superatoms.
Basit Böbrek Kistlerinin Perkütan Aspirasyon ve Skleroterapisi: Tedavi Başarısında Etkili Faktörler
Authors: AKÇALAR Seray , KHALATAİ Behruz , AKHAN Okan 
Published: February 2023

Amaç: Semptomatik böbrek kistlerinin tedavisinde perkütan aspirasyon ve etanol skleroterapinin (PAS) güvenliğini, etkinliğini ve uzun dönem sonuçlarını değerlendirmek

Gereç ve Yöntem: 2004 – 2020 yılları arasında tedavisinde perkütan aspirasyon ve etanol skleroterapi ile tedavi edilen 82 hasta, 90 kist retrospektif olarak değerlendirildi. Ortalama hasta yaşı 60.6 (28-86 arası) olup, 67 hasta yağ ağrısı (%81.8), 7 hasta hipertansiyon (%8.6), 3 hasta hidronefroz (%3.5) nedeniyle tedavi edildi. Ortalama takip süresi 59 aydı (1-220 ay). Girişimden sonra ardışık olarak 1, 3, 6, 12, 18. Ve 24. aylarda ve sonrasında yıllık olmak üzere takip edildi.
Bulgular: Teknik başarı %100’dü. Prosedür ilişkili mortalite görülmedi. İşlem sonrası 3 (%3.9) hastada yan ağrısı, 1 hastada (% 1.3) hematüri gelişti. Hastaların 5’i ilk bir yıl içinde takipleri bıraktı. Birinci yıl sonunda ortalama kist hacminde azalma %93 olup kistlerin 19’u tamamen kayboldu. Bir yıllık takip sonunda radyolojik tam/tama yakın yanıt 77 hastanın 67’sinde (%78); parsiyel yanıt 13 hastada saptandı. Beş hastada tedaviye radyolojik yanıt yoktu.

Sonuç: Semptomatik böbrek kistlerinin tedavisinde Ultrasonografi eşliğinde PAS, basit, iyi tolere edilen bir teknik olup düşük komplikasyon riski ve yüksek teknik başarı ile güvenle uygulanabilir.
Kutanöz Malign Melanom Nedeniyle Takip Ettiğimiz Hastaların Klinikopatolojik Özellikleri
Authors: DOĞAN Özlem , DUZKOPRU Yakup , ŞAHİNLİ Hayriye 
Published: February 2023

ÖZ
Amaç: Bu çalışmada, merkezimizde kutanöz malign melanom tanısı alan hastaların demografik özelliklerini, aldıkları tedavileri ve yanıtlarını incelemeyi amaçladık.
Gereç ve Yöntemler: Temmuz 2012- Haziran 2022 arasında onkoloji kliniğimizde malign melanom tanısı alan 45 hasta retrospektif olarak taranarak toplam 32 hasta çalışmaya dahil edildi. Klinik ve demografik veriler deskriptif analizlerle sunuldu. Kategorik ve numerik değişkenler sayı ve yüzde olarak verildi(n,%). PFS ve OS Kaplan-Meier metoduyla hesaplandı.
Bulgular: Çalışmaya dahil edilen hastaların 19’u(%59.4) erkek, 13’ü kadın(%40.6) idi. Hastaların median yaşı 65 (38-86) idi. Primer tümör sırasıyla 13(%40.6) hastada extremitede, 6(%18.8) hastada gövdede ve 13(% 40.6) hastada baş-boyunda yerleşimli idi. 8(%25) hastada BRAF mutasyonu mevcuttu. Hastaların 22(%68.7)’si metastatik evrede idi. Metastatik evredeki hastalarda progresyonsuz sağkalım(PFS) 5.2 ay (std. err:1.21, %95CI:2.86-7.59) iken, median genel sağkalım(OS) 23.9 (std. err:3.65, %95CI:16.8-31.11) ay idi.
Sonuç: Sonuç olarak kutanöz malign melanom en sık görülen beşinci kanserdir. İleri evrede mortalite oranları çok yüksektir ve multidisipliner takip gerekmektedir.
Small-Scale EOR Pilot in the Eastern Eagle Ford Boosts Production
Authors: Bozeman Tim , Nelle Will , Nguyen Quoc 
Published: February 2023

Summary
Low primary and secondary recoveries of original oil in place from modern unconventional reservoirs beg for utilization of tertiary recovery techniques. Enhanced oil recovery (EOR) via cyclic gas injection (“huff ‘n’ puff”) has indeed enhanced the oil recovery in many fields, and many of those projects have also been documented in industry technical papers/case studies. However, the need remains to document new techniques in new reservoirs. This paper documents a small-scale EOR pilot project in the eastern Eagle Ford and shows promising well results.
In preparation for the pilot, full characterization of the oil and injection gas was done along with laboratory testing to identify the miscibility properties of the two fluids. Once the injection well facility design was completed, a series of progressively larger gas volumes were injected followed by correspondingly longer production times. Fluids in the returning liquid and gas streams were monitored for compositional changes, and the learnings from each cycle led to adjustments and facility changes to improve the next cycle.
After completing five injection/withdrawal cycles in the pilot, a few key observations can be made. The implementation of cyclic gas injection can be both a technical and a commercial success early in its life if reasonable cost controls are implemented and the scope is kept manageable. The process has proved to be both repeatable and predictable, allowing for future economic modeling to be used to help determine timing of subsequent injection cycles. A key component of the success of this pilot has been the availability of small compressors capable of the high pressures required for these projects and learning how to implement cost saving facility designs that still meet high safety standards.
Improving Drilling Efficiency and Safety Based on Hydraulic Mechanical Specific Energy in the Framework of Economic Model Predictive Control
Authors: Xu Baochang , Meng Zhuoran , Liu Wei , Luo Xionglin , Chen Yiqi 
Published: February 2023

Summary
The economic value of real-time optimization of the drilling process has attracted extensive attention in the period of crude oil price fluctuation. Because of the complicated bottomhole conditions and coupling relationship among subsystems, it is difficult for the driller to continuously adjust the primary manipulation variables—weight on bit (WOB), revolutions per minute (RPM), and managed pressure drilling (MPD) equipment—which leads to unsatisfactory drilling effect and increased nonproductive time. Here, we propose an integrated control strategy based on economic model predictive control with zone tracking (ZoneEMPC), nonlinear model predictive control (NMPC), and Lyapunov-based model predictive control (LMPC) to optimize hydraulic mechanical specific energy (HMSE) while stabilizing bottomhole pressure (BHP).
During normal drilling, ZoneEMPC is used to minimize HMSE through operating RPM, WOB, mud pump flow, and choke-valve opening as well as its tracking performance, which ensures that the BHP is maintained within the pressure window. Moreover, the controller is switched to NMPC, which adjusts the BHP to quickly reach the new setting zone. The reason for controller switching is that the tracking accuracy of ZoneEMPC could decline when encountering high-pressure formation with gas invasion. As the BHP reaches the new pressure range, the controller is switched to ZoneEMPC again and the HMSE is reoptimized. In addition, the transmission rate of mud pulse telemetry is not enough to meet the real-time control in practical engineering. Therefore, the LMPC controller is used to ensure the closed-loop stability of the system when the downhole measurement data (e.g., BHP) delayed.
This study uses the drilling data of a vertical well located in Tarim, China, to verify the control strategy. The results indicated that the proposed integrated control strategy could improve the rate of penetration (ROP), especially in a formation with high rock strength. Meanwhile, the BHP could be adjusted efficiently and stably under different conditions. This work provides a unified framework integrating multiple system models for practical engineering, which has certain theoretical guiding significance for the automation and intelligent development of the oil and gas industry.
Efficient Synthesis of Chlorin e6 and its Potential Photodynamic Immunotherapy in Mouse Melanoma by the Abscopal Effect
Authors: Kim Yong-Wan , Mallik Shyam Kumar , Shrestha Rajeev , Lim Junmo , Gurung Pallavi , Magar Til Bahadur Thapa 
Published: February 2023

Abstract
Background
Photodynamic therapy (PDT) can eradicate not only cancer cells but also stimulate an anti-tumor immune response. Herein, we describe two efficient synthetic methodologies for the preparation of the second generation of photosensitizer Chlorin e6 (Ce6) from Spirulina platensis in higher yield and purity, and we address the phototoxic effect of Ce6 in vitro along with anti-tumor activity due to photodynamic therapy in vivo.
Methods
The use of different solvents, the duration of extraction/reaction, and the yield were analyzed and compared between the two methods during the synthesis of Ce6. The synthesized Ce6 was evaluated by TLC, HPLC, LC/MS, NMR, and studied for the anti-tumor activity of melanoma in vitro and in vivo. Melanoma B16F10 cells were seeded and phototoxicity was monitored by the MTT assay. C57BL/6 mice were transplanted with B16F10 cells for the tumor allograft model. The mice were subcutaneously inoculated on the left and right flank with 0.1 mL of B16F10 cells (1×106 cells/mL). The treated mice were intravenously injected with Ce6 of 2.5 mg/kg and then exposed to red light (660 nm) on the left flank tumors at 3 h after the injection.
Results
Our results revealed that the tumor was suppressed not only in the left flank but also in the right flank, where no PDT was given. The immune response was also studied by analyzing Interferon-gamma (IFN-γ), Tumor necrosis factor-alpha (TNF-α), and Interleukin-2 (IL-2) of the right flank tumors through qPCR. The upregulated expression of IFN-γ, TNF-α, and IL-2 revealed the local anti-tumor immunity due to Ce6-PDT.
Conclusion
The finding of this study suggest an efficient methodology of Ce6 preparation and the efficacy of Ce6-PDT as a promising anti-tumor immune response.
Kidney tubular epithelial cells control interstitial fibroblast fate by releasing TNFAIP8-encapsulated exosomes
Authors: Liu Xi , Liu Zhao , Wang Cong , Miao Jinhua , Zhou Shan , Ren Qian , Jia Nan , zhou Lili , Liu Youhua 
Published: February 2023

Abstract
Kidney fibrosis, characterized by the activation and expansion of the matrix-producing fibroblasts, is the common outcome of chronic kidney disease (CKD). While fibroblast proliferation is well studied in CKD, little is known about the regulation and mechanism of fibroblast depletion. Here, we show that exosomes derived from stressed/injured tubules play a pivotal role in dictating fibroblast apoptosis and fate. When human kidney tubular cells (HK-2) were stimulated with TGF-β1, they produced and released increased amounts of exosomes (TGFβ-Exo), which prevented renal interstitial fibroblasts from apoptosis. In vivo, injections of TGFβ-Exo promoted renal fibroblast survival, whereas blockade of exosome secretion accelerated fibroblast apoptosis in obstructive nephropathy. Proteomics profiling identified the tumor necrosis factor-α-induced protein 8 (TNFAIP8) as a key component enriched in TGFβ-Exo. TNFAIP8 was induced in renal tubular epithelium and enriched in the exosomes from fibrotic kidneys. Knockdown of TNFAIP8 in tubular cells abolished the ability of TGFβ-Exo to prevent fibroblast apoptosis. In vivo, gain- or loss- of TNFAIP8 prevented or aggravated renal fibroblast apoptosis after obstructive injury. Mechanistically, exosomal-TNFAIP8 promoted p53 ubiquitination leading to its degradation, thereby inhibiting fibroblasts apoptosis and inducing their proliferation. Collectively, these results indicate that tubule-derived exosomes play a critical role in controlling the size of fibroblast population during renal fibrogenesis through shuttling TNFAIP8 to block p53 signaling. Strategies to target exosomes may be effective strategies for the therapy of fibrotic CKD.
Assessment of Multiple-Opinion Referrals and Consults at the BC Children’s Hospital Allergy Clinic
Authors: Sage Adam Patrick , James Elliot , Burke Megan , Chan Edmond S , Wong Tiffany 
Published: February 2023

Abstract
Background: Allergic disease is on the rise. Waitlists for specialists are long, and many referrals have already received prior allergic assessment. It is important to understand the prevalence and motivating factors for second opinion referrals, to deliver timely assessment for patients with allergic disease.
Methods:A retrospective chart review of demographic information, referral patterns, and motivation for new consults of pediatric patients aged 8 months – 17 years to BC Children’s Hospital Allergy Clinic from September 1, 2016 – August 31, 2017, was performed. Data were accessed through local Electronic Medical Records and subsequently analyzed for frequency and motivation for referrals to our clinic.
Results: Of 1029 new referrals received, 210 (20.4%) were multiple-opinion referrals. Food allergy was the predominant allergic concern prompting another opinion (75.7%). The main rationale for seeking further opinions was looking to speak with a certified Allergist, or dissatisfaction with previous opinions.
Conclusions: Many new consults at the BCCH Allergy Clinic are multiple-opinion assessments, contributing to long waitlists and poor patient satisfaction. Advocacy at the systems level is needed to provide better access in Canada for children needing a specialized Allergist.
Trial Registration - UBC/BCCH Research Ethics Board (H18-02528)
WITHDRAWN: Properties of Cake and Pogaca Enriched With Carob Molasses Pulp Flour
Authors: Özdemir Yüksel , YALIMKAYA SERPIL , İlhan Sevcan 
Published: February 2023

Abstract
Carob molasses pulp is a waste or by-product in carob molasses and carob syrup production. However, it contains nutritive elements like dietary fiber and polyphenols. In this study, carob molasses pulp flour (CMP) was used in cake and pogaca formulations to substitute 5, 10, and 15% of wheat flour, and its quality characteristics were investigated. The results showed that CMP addition resulted in similar results for pogaca and cakes. The use of CMP in pogaca and cake formulations caused a strong reduction in lightness and yellowness; the color of pogaca and cakes were darker, redder, and less yellow than the control, depending on the substitution level. The volume and weight loss value of pogaca and cake did not change. The hardness slightly increased, but only 15% CMP added sample was significantly different (p < 0.05) from the control. However, sensory qualities of pogaca and cakes with CMP were observed close to control. Practical Application: Thus, the nutritional values of cake and pogaca increased economically by using waste CMP