bluuebunny/crossref_metadata_2025_split huggingface dataset:
Endoscopic Treatment of Stump Infection of the Residual Synovial Cavity After Through-the-Knee Amputation
Authors: Furrer Pascal R. , Zimmermann Stefan M. , Böni Thomas , Waibel Felix W.A. 
Published: December 2022

Case:
We report the case of a 35-year-old patient who presented with a septic residual synovial cavity infection 8 weeks after a through-the-knee amputation because of a parosteal sarcoma. An endoscopic evacuation of the turbid fluid and synovial debridement through parapatellar portals as in a standard knee arthroscopy was performed, in conjunction with appropriate antibiotic therapy. One year postoperatively, there were no signs of residual infection.

Conclusion:
Endoscopic treatment of a septic stump infection of the residual synovial cavity after through-the-knee amputation is feasible. In our case, this approach resulted in rapid wound healing and early prosthesis mobility.
Bundled Care in Elective Total Joint Replacement: Payment Models in Sweden, Canada, and the United States
Authors: Sniderman Jhase , Krueger Chad , Wolfstadt Jesse 
Published: December 2022

» Rising health-care expenditures and payer dissatisfaction with traditional models of reimbursement have driven an interest in alternative payment model initiatives.» Bundled payments, an alternative payment model, have been introduced for total joint replacement in Sweden, the United States, and Canada to help to curb costs, with varying degrees of success.» Outpatient total knee arthroplasty and total hip arthroplasty are becoming increasingly common and provide value for patients and payers, but have negatively impacted providers participating in bundled payment models due to considerable losses and decreased reimbursement.» A fine balance exists between achieving cost savings for payers and enticing participation by providers in bundled payment models.» The design of each model is key to payer, provider, and patient satisfaction and should feature comprehensive coverage for a full cycle of care whether it is in the inpatient or outpatient setting, is linked to quality and patient-reported outcomes, features appropriate risk adjustment, and sets limits on responsibility for unrelated complications and extreme outlier events.
Surgeon-Performed Intraoperative Peripheral Nerve Blocks and Periarticular Infiltration During Total Hip and Knee Arthroplasty
Authors: Drapeau-Zgoralski Véronique , Bourget-Murray Jonathan , Hall Brandon , Horton Isabel , Dervin Geoffrey , Duncan Kenneth , Addy Keith , Garceau Simon 
Published: December 2022

» Surgeon-performed intraoperative peripheral nerve blocks may improve operating room efficiency and reduce hospital resource utilization and, ultimately, costs. Additionally, these blocks can be safely performed intraoperatively by most orthopaedic surgeons, while only specifically trained physicians are able to perform ultrasound-guided peripheral nerve blocks.» IPACK (infiltration between the popliteal artery and capsule of the knee) blocks are at least noninferior to periarticular infiltration when combined with an adductor canal block for analgesia following total knee arthroplasty.» Surgeon-performed intraoperative adductor canal blocks are technically feasible and offer reliable anesthesia comparable with ultrasound-guided blocks performed by anesthesiologists. While clinical studies have shown promising results, additional Level-I studies are required.» A surgeon-performed intraoperative psoas compartment block has been described as a readily available and safe technique, although there is some concern for femoral nerve analgesia, and temporary sensory changes have been reported.
Arthroscopic Remplissage for the Treatment of Anterior Shoulder Instability
Authors: Hwang Simon T. , Horinek Jeffrey L. , Ardebol Javier , Menendez Mariano E. , Denard Patrick J. 
Published: December 2022

» A Hill-Sachs lesion (HSL) is a compression fracture on the posterolateral humeral head that can increase the risk of recurrent shoulder instability after isolated arthroscopic Bankart repair.» Remplissage involves capsulotenodesis of the infraspinatus tendon and posterior capsule into the HSL to prevent its engagement with the glenoid rim through extra-articular conversion and restraint against humeral head anterior translation.» The glenoid track concept can be applied preoperatively and intraoperatively to evaluate risk of recurrence and help direct clinical management options for recurrent shoulder instability.» Recent literature supports expanding indications for remplissage to include patients with on-track HSLs who are at increased risk of recurrence including collision athletes, military personal, and patients with joint hyperlaxity.» New techniques and suture constructs have demonstrated improved biomechanical strength while avoiding the need to access the subacromial space.
Reconstructing paleosinuosity and sedimentary mass balance in the Upper Triassic Shinarump paleoriver in Utah and Arizona, U.S.A.
Authors: Hayes Robert , DeCelles Peter 
Published: December 2022

ABSTRACT
The Upper Triassic Shinarump Member forms the basal part of the Chinle Formation in the western interior United States and was deposited by a continental-scale fluvial system which ran approximately 2,500 km from the Ouachita Orogen in the east into the Auld Lang Syne marine basin in the west. Previous studies of the Shinarump Member have concluded that the deposits represent a braided-river system but have not produced estimates for paleo-sinuosity and paleo-discharge. Recent advances in sedimentology allow detailed morphometric assessment of the nature of the river system that deposited the Shinarump Member enabling us to produce quantitative estimates for these parameters. We therefore present architectural data from the Shinarump Member in northern Arizona and Utah, supported by lithofacies data and 39 sandstone petrographic analyses, and a dataset of 4,298 paleocurrent measurements from trough cross-strata.
Lithofacies and architectural analysis supports previous interpretations of the Shinarump and equivalent strata as braided-river deposits. Petrographic analysis shows that the Shinarump is dominated by monocrystalline quartz and exhibits low spatial variation in composition, ranging from 85.4% to 99.8% total quartz. Paleocurrent measurements are used to calculate the channel sinuosity of the fluvial system as varying between 1.02 and 1.77, with a median value of 1.33 (compared to the Yangtze River, ranging from 1.05 to 1.50 and the Ganges–Brahmaputra, ranging from 1.05 to 1.13 in their lower 250 km). Paleohydrological estimates using data from the architectural surveys produce slope estimates from 2.01 × 10–4 to 6.51 × 10–4 and bankfull discharge estimates from 4.36 × 103 m3 s–1 to 2.38 × 104 m3 s–1 for individual channels, comparable to extant continental-scale fluvial systems. Estimates of lifetime sediment transport volume range from 7.75 × 104 km3 to 6.09 × 105 km3, which are in order-of-magnitude agreement with estimates for the volume of the depositional sink (1.35 × 105 km3 to 4.17 × 105 km3). These results demonstrate the potential for paleohydrologic estimates to provide new avenues for analysis of heavily studied units.
Developing Evidence on Water, Sanitation and Hygiene Facilities in the Climate Vulnerable Slums through WASH Poverty Index: A Case Study on Selected Slums in Rajshahi City Corporation, Bangladesh
Authors: Tabassum Tahsin , Fatema-Tuz-Zohora  , Manzoor-Al-Islam Saief , Tahsin Nazwa 
Published: December 2022

Abstract
At present, people worldwide are facing the negative impacts of climate change. On top of that, Bangladesh is one of the most climate vulnerable countries. Many climate migrants from rural vulnerable areas now choosing to seek refuge in slums of cities in Bangladesh. The study has identified the WASH condition of the selected slums in Rajshahi district through WASH poverty index, a multidimensional, WASH-focused, thematic indicator that is also a powerful tool for planning, targeting and prioritizing WASH challenges. Through integrated analysis of WASH and poverty linkages, the index assists to identify key issues which can guiding policymakers towards appropriate action. The index itself is an agglomeration of 3 different indices and few more subindices comprising them. Among those, water poverty index (WPI) accounts for availability, accessibility, water points, use of water and relevant environment. The second indicator, sanitation poverty index (SPI), considers access, capacity, and use. Lastly, hygiene poverty index (HPI) deals with water safety plan, food hygiene, personal hygiene, and domestic hygiene. Weightage of the sub-indices have been determined by literature review and experts’ opinion. The indices and WASH poverty index is measured using the method of multivariative summation and arithmetic mean respectively. While the SPI and HPI both are lowest in the slum named Ashrayan, WPI is the lowest in Char Christan Para. Almost half of the slum dwellers of Char Christan don’t have access to pure water. Interestingly, 67% respondents from all slums using shared toilets, and more than half respondents considered the toilets unhygienic, SPI of all slums are close to zero. Based on the study, people are most likely to maintain hygiene, but to do so is difficult due to economic crisis and lack of service provision. Overall, though Ashrayan has the lowest WASH poverty index, each slum is lagging behind mainly in maintaining a standard level of sanitation facilities and hygiene.
Targeting JunB Induces a Shift of Low- to High-thermogenic Adipocytes and Ameliorates Diet-induced Insulin Resistance
Authors: Zhang Xing , Ding Xiaofeng , Wang Chunqing , Le Que , Wu Dandan , Song Anying , Huang Guixiang , Luo Liping , Luo Yan , Yang Xin , Goins Aleyah , Desai Sharina , Silva Floyd , Feldman Lily , Spafford Michael , Boyd Nathan , Prossnitz Eric , Yang Xuexian , Wang Qiong , Liu Meilian 
Published: December 2022

Abstract
The coexistence of brown adipocytes with low and high thermogenic activity is a fundamental feature of brown adipose tissue (BAT) heterogeneity and plasticity. However, the mechanisms that govern thermogenic adipocyte heterogeneity and its significance in obesity and metabolic disease remain poorly understood. In the current study, we identified a population of JunB-enriched adipocytes (JunB+ adipocytes) within the brown fat depot that exhibits lower thermogenic capacity and smaller lipid droplets compared to high-thermogenic adipocytes. This population of JunB+ adipocytes exhibited marked expansion during obesity, in part through the induction of pro-inflammatory cytokines TNFα and IL-6. Depletion of JunB in adipocytes or UCP1+ adipocytes increased the fraction of adipocytes exhibiting high mitochondrial content and thermogenic capacity, leading to enhanced basal and cold-induced energy expenditure and protection against diet-induced obesity and insulin resistance. Mechanistically, JunB directly binds to the promoter of estrogen-related receptor α (Errα), a downstream effector of PGC1α, and suppresses its transcriptional function. JunB antagonizes the stimulatory effects of PGC1α-ERRα on mitochondrial biogenesis and high-thermogenic adipocyte formation. Taken together, our studies uncover a novel mechanism involving JunB that integrates metabolic and inflammatory signals and shapes the thermogenic adipocyte heterogeneity, serving a critical role in maintaining systemic metabolic health.
On some properties of the compliance-volume fraction Pareto front in topology optimization useful for material selection.
Authors: Duriez Edouard , Charlotte Miguel , Azzaro-Pantel Catherine , Morlier Joseph 
Published: December 2022

Abstract
Selecting the optimal material for a part designed through topology optimization is a complex problem. The shape and properties of the Pareto front plays an important role in this selection. In this paper we show that the compliance-volume fraction Pareto fronts of some topology optimization problems in linear elasticity share some useful properties. These properties provide an interesting point of view on the efficiency of topology optimization compared to other design approaches such as parametric structural optimization. We construct a simple meta-model which requires only one full topology optimization to fit the whole Pareto fronts. Precise Pareto fronts are obtained independently. The fast meta-model constructed has a maximum error of 6.4% with respect to these precise Pareto fronts, on the different problems tested. The selection of the optimal material is then successfully tested on the mass minimization of an MBB beam with an illustrative choice of 4 materials.
Sperm physiology and in vitro fertility outcomes rely on their basal metabolic activity
Authors: Mateo-Otero Yentel , Madrid-Gambin Francisco , Llavanera Marc , Gomez-Gomez Alex , Haro Noemi , Pozo Oscar , Yeste Marc 
Published: December 2022

Abstract

Although looking into the sperm metabolome could help to estimate the reproductive performance, no study has investigated through which mechanisms might sperm metabolism influence fertility outcomes. In this context, the present work sought to interrogate the energy source preferred by pig sperm, as well as the relationship of energetic metabolism with sperm quality, function andin vitrofertilisation (IVF) outcomes. To this end, a targeted metabolomic approach was used to determine the levels of metabolites belonging to glycolysis, ketone bodies and polycarboxylic acids cycle. Here we show that high-quality sperm were associated to greater levels of glycolysis derived metabolites. Additionally, embryo development, but not oocyte fertilisation, was conditioned by sperm metabolic status. Specifically, glycolysis appeared to be the preferential catabolic pathway in sperm giving rise to greater IVF outcomes. This study shows that the basal metabolic activity of sperm influences their function, even beyond post-fertilisation events.
Disrupted topological organization of functional brain networks in traumatic axonal injury
Authors: Li Jian , Shu Yongqiang , Chen Liting , Wang Bo , Chen Linglong , Zhan Jie , Kuang Hongmei , Xia Guojin , Zhou Fuqing , Gong Honghan , Zeng Xianjun 
Published: December 2022

Abstract
Traumatic axonal injury (TAI) may result in the disruption of brain functional networks and is strongly associated with cognitive impairment. However, the neural mechanisms affecting the neurocognitive function after TAI remain to be elucidated. We collected the resting-state functional magnetic resonance imaging data from 28 patients with TAI and 28 matched healthy controls. An automated anatomical labeling atlas was used to construct a functional brain connectome. We utilized a graph theoretical approach to investigate the alterations in global and regional network topologies, and network-based statistics analysis was utilized to localize the connected networks more precisely. The current study revealed that patients with TAI and healthy controls both showed a typical small-world topology of the functional brain networks. However, patients with TAI exhibited a significantly lower local efficiency compared to healthy controls, whereas no significant difference emerged in other small-world properties (Cp, Lp, γ, λ, and σ) and global efficiency. Moreover, patients with TAI exhibited aberrant nodal centralities in some regions, including the frontal lobes, parietal lobes, caudate nucleus, and cerebellum bilaterally, and right olfactory cortex. The network-based statistics results showed alterations in the long-distance functional connections in the subnetwork in patients with TAI, involving these brain regions with significantly altered nodal centralities. These alterations suggest that brain networks of individuals with TAI present aberrant topological attributes that are associated with cognitive impairment, which could be potential biomarkers for predicting cognitive dysfunction and help understanding the neuropathological mechanisms in patients with TAI.
Territórios teatrais a partir das máscaras brincantes
Authors: Gomes Vanéssia 
Published: December 2022

Este artigo trata sobre as máscaras teatrais presentes nas manifestações tradicionais populares. Trago como questão demarcadora desenvolver um pensamento que apresente as manifestações tradicionais como lugar de referência para os estudos e práticas de procedimentos de atuação teatral. Associo a este pensamento as experiências criadas e executadas por brincantes, mestras e mestres que partem de práticas cênicas construídas e repassadas entre si, e entre grupos. Intento colaborar com artistas/pesquisadores(as) de teatro que tomam como referência estas práticas para suas criações, resultando em diversos tipos de aproximações, diálogos, encontros e similitudes. Proponho a articulação de matrizes que possam ser deflagradoras de novos campos de investigação a partir da cena popular. Estas inquietudes emergem do meu trabalho, como atriz e diretora, desde os processos de pesquisa e criação que dei início no princípio dos anos 90, onde também ocorre minha aproximação a estas expressões. Destaco nesta trajetória os espetáculos e as investigações desenvolvidas como integrante do Grupo Teatro de Caretas (CE).
Synthesis of Piperidine Conjugated Quinoxalines as Potential Antibiofilm Agents
Authors: Shruthi Jeegundipattana B. , Kiran Kuppalli R. , Gunashree Kodagahally T. , Divyashree Shivakumar , Sreenivasa Marikunte Y. , Sadashiva Maralinganadoddi P. , Rangappa Kanchugarakoppal S. 
Published: December 2022

Background:
The most common cause of food-borne illness is bacterial or viral contamination.
Although there are several therapeutics available to combat these microbes, they lost their efficacy in
long-term medication. Because, over a period of time, microbes developed resistance against drugs and
this antimicrobial resistance is a serious threat to global public health as a consequence of the widely disseminated
and careless use of antimicrobials. Therefore, there is a need to develop some new chemical
moieties with a safety factor and better efficacy. A series of substituted N-(1-benzylpiperidin-4-
yl)quinoxalin-2-amines (5a-j) (5ab, 5ac) were synthesized and screened for their in vitro antibacterial
activity against Salmonella paratyphi, a well-known food-borne pathogen.

Methods:
Experimental methods, agar diffusion and broth microdilution assays were carried out to evaluate
the antibacterial activity of the lead compounds. Further, antibiofilm methods, crystal violet, and MTT
assays were subjected to investigate their biofilm inhibition capacity against S. paratyphi.

Results:
Among the tested compounds, 5b, 5e, 5h, and 5j bearing 4-chloro, 3,4-dimethoxy, 4-methyl and
thienyl groups on the phenyl ring of quinoxalines emerged as potential candidates having significant antisalmonella
activity. In these four potential candidates, compounds 5b and 5h were effective against Salmonella
whereas compounds 5e and 5j effectively inhibited the biofilm formation of Salmonella.

Conclusion:
N-(1-benzylpiperidin-4-yl)quinoxalin-2-amines (5a-j) (5ab, 5ac) were synthesized and evaluated
for antisalmonella activity against S. paratyphi. Among the series of compounds, four compounds
significantly showed good activity and emerged as antibacterial agents for further studies in the future.
Synthesis and Anticancer Activity of Novel Chromene Derivatives,
Chromeno[2,3-d][1,3]Oxazines, and Chromeno[2,3-d]Pyrimidines
Authors: Yousif Mahmoud N.M. , Fathy Usama , Yousif Nabil M. 
Published: December 2022

Background:
Several chromene derivatives have a wide variety of biological and pharmacological
activity. They had anticancer activity, antimicrobial activity, antituberculosis activity, anticonvulsant
activity, antidiabetic activity, antichlolinesterase activity, and inhibitor of monoamine
oxidase activity. The above-mentioned activities directed us to synthesize novel chromene derivatives,
chromeno[2,3-d][1,3]oxazines, and chromeno[2,3-d]pyrimidines. The starting material was 2-
amino-8-(2-chlorobenzylidene)-4-(2-chlorophenyl)-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile.

Methods:
Several novel chromene derivatives had been synthesized. Compound 1 reacted with carbon
disulfide, and ethyl chloroformate to afford chromene derivatives 2, 3. Chromene derivative 3
reacted with hydrazine dydrate to give compound 4. Chromene derivative 1 reacted with acetic acid
and sulphuric acid to produce compounds 5, and 6. Amino derivative 5 reacted with chloroacyl derivative
to afford compounds 7a-c which cycalized in dry xylene to afford compounds 8a-c.
Chromene derivative 8a reacted with hydroxyl amine to afford compound 9.

Results:
The structures of novel synthesized chromene derivatives had been confirmed using mass
spectroscopy, infrared spectroscopy, nuclear magnetic resonance spectroscopy, and elemental analysis.
Most of the prepared compounds were screened against liver cancer cell lines (HepG-2), human
colon cancer cell lines (HT-29), and breast adenocarcinoma cell lines (MCF-7). Chromene derivative
2 had anticancer activity against human colon cancer cell lines (HT-29) higher than the reference
drug doxorubicin. The rest of the tested compounds had anticancer activity against human colon
cancer cell lines (HT-29) lower than that of the reference drug doxorubicin. Chromene derivative 5
had anticancer activity against liver cancer cell lines (HepG-2) higher than the reference drug doxorubicin.

Conclusion:
Several chromene derivatives had been synthesized and their structures had been confirmed
using different spectroscopic techniques. Some of the chromene derivatives that were
screened against different cancer cell lines showed promising anticancer activity higher than the reference
standard drug. For example, chromene derivative 2 had anticancer activity against human
colon cancer cell lines (HT-29) higher than the reference drug doxorubicin. Chromene derivative 5
had anticancer activity against liver cancer cell lines (HepG-2) higher than the reference drug doxorubicin.
Chromene derivative 6 had anticancer activity against breast adenocarcinoma cell lines
(MCF-7) higher than the standard drug.
Relation between Apolipoprotein E in Alzheimer’s Disease and
SARS-CoV-2 and their Treatment Strategy: A Review
Authors: Ramachandran Anu Kunnath , Das Subham , Shenoy Gurupur Gautham , Mudgal Jayesh , Joseph Alex 
Published: December 2022

Abstract:
COVID-19, which primarily affects the pulmonary system, turned out to be a global pandemic,
whereas the effects on other systems are still unknown. SARS-CoV-2, binds to angiotensinconverting
enzyme 2 (ACE2) receptors in the lungs, causing pneumonia-like symptoms. The same
ACE receptors are also present in organs other than the lungs. Therefore, there is a need to study the
impact of coronavirus on other human body organs. Recently, UK Biobank reports on the genetic risk
factor of the virus attack. A double mutation in the apolipoprotein E (APOE4) allele has shown a significant
role in COVID-19. The same APOE4 mutation has already been proven to hold a key role in
developing early-onset Alzheimer’s disease (EOAD). Despite this data, Alzheimer’s disease is believed
to be a comorbidity of COVID-19. Previous virus attacks on the same viral family, Coronaviridae,
produced neurological effects like neurodegeneration, neuronal inflammation, and other central
nervous system-related dysfunctions. Since the long-term implications of COVID-19 are unknown,
more research into the impact of the virus on the central nervous system is needed. Both COVID-19
and AD share a common genetic factor, so that AD patients may have a greater risk of SARS-CoV-2.
Here, in this review, we have briefly discussed the role of APOE4 in the pathogenesis of AD and
SARS-CoV-2, along with their treatment strategy, current scenario, and possible future directions.