bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bevacizumab reduces peritumoral brain edema in lung cancer brain metastases after radiotherapy
Authors: Hua Yi‐Chun , Gao De‐Zhi , Wang Kuan‐Yu , Ding Xiao‐Sheng , Xu Wei‐Ran , Li Yu‐Bin , Shi Wei‐Wei , Sun Shi‐Bin , Li Xiao‐Yan 
Published: September 2023

AbstractBackgroundThe aim of this study was to investigate the efficacy of bevacizumab (Bev) in reducing peritumoral brain edema (PTBE) after stereotactic radiotherapy (SRT) for lung cancer brain metastases.MethodsA retrospective analysis was conducted on 44 patients with lung cancer brain metastases (70 lesions) who were admitted to our oncology and Gamma Knife center from January 2020 to May 2022. All patients received intracranial SRT and had PTBE. Based on treatment with Bev, patients were categorized as SRT + Bev and SRT groups. Follow‐up head magnetic resonance imaging was performed to calculate PTBE and tumor volume changes. The edema index (EI) was used to assess the severity of PTBE. Additionally, the extent of tumor reduction and intracranial progression‐free survival (PFS) were compared between the two groups.ResultsThe SRT + Bev group showed a statistically significant difference in EI values before and after radiotherapy (p = 0.0115), with lower values observed after treatment, but there was no difference in the SRT group (p = 0.4008). There was a difference in the distribution of EI grades in the SRT + Bev group (p = 0.0186), with an increased proportion of patients at grades 1–2 after radiotherapy, while there was no difference in the SRT group (p > 0.9999). Both groups demonstrated a significant reduction in tumor volume after radiotherapy (p < 0.05), but there was no difference in tumor volume changes between the two groups (p = 0.4089). There was no difference in intracranial PFS between the two groups (p = 0.1541).ConclusionBevacizumab significantly reduces the severity of PTBE after radiotherapy for lung cancer. However, its impact on tumor volume reduction and intracranial PFS does not reach statistical significance.
The Water‐Exclusion Trap (WET): A 3D printable window trap collector that prevents DNA degradation
Authors: Lee Seunghyun , Seung Jinbae , Yang Yunho , Orr Michael , Lee Minhyeuk , Tak Jun‐Hyung , Vogler Alfried P. , Bai Ming , Lee Seunghwan 
Published: September 2023

Abstract

Sampling is one of the most important and fundamental processes in field biology. Among many sampling methods in entomology, window traps have long been considered one of the most effective and standardized methods. Unfortunately, the DNA quality of samples collected by window traps is typically low due to incursion by water, mainly via rainfall. Water cannot be avoided in long‐term surveys, even with a roof, due to wind and condensation. As we move into the genomics era, this shortfall in DNA quality has become problematic for molecular biomonitoring, and solutions are urgently needed.

In this study, we developed the Water‐Exclusion Trap (WET), a 3D printable long‐term storable bottom collector for window or pitfall traps. The collection medium in WETs does not dilute because water is excluded and evaporation is limited, maximizing DNA preservation.

Our field tests show that the WET outperforms conventional traps in preserving DNA quality. Insect samples preserved in WETs in the field had significantly higher PCR success rates and DNA Integrity Numbers compared to conventional traps.

The WET addresses a critical challenge in the use of window traps, DNA degradation caused by water intrusion, and represents a significant advancement in fieldwork for genomic research in entomology. We provide the 3D printing template of the WET, enabling immediate, free use for all. Furthermore, it can be easily customized for different environments and purposes, and can be adapted to a variety of other traps, including pitfall traps, funnel traps and more.
Deroceras laeve as a potential agricultural pest in Darjeeling Himalayas, India: Palatability and preference of economically important plants
Authors: Gupta Neha Kumari , Paul Pranesh , Aditya Gautam 
Published: September 2023

AbstractThe invasion of the terrestrial ecosystem by gastropods has immense negative impacts on ecosystem functions, health, and agricultural plants. The non‐native slug, Deroceras laeve (O. F. Müller, 1774), a recognised agricultural pest in native and invaded regions, was recently reported from the Darjeeling Himalayas, India. We assessed the plant palatability and preference of D. laeve using selected plants being farmed in Darjeeling Himalayas (basil, cabbage, coriander, lettuce, mint, pumpkin leaf, and spinach) by laboratory‐based choice and non‐choice experiments. Moreover, we evaluated the correlation between different chemical features of the plants with the consumption rate of D. laeve and observed the fecundity of D. laeve reared on different plant diets. The highest consumption rate of D. laeve was observed for pumpkin (12.99 ± 1.33 mg dry mass) and the lowest for mint (1.63 ± 0.13 mg dry mass), with a significant positive correlation between consumption rate and D. laeve body mass (for lettuce: R = .47, p = .0009 and other plant species: R = .52, p = .00004) was observed through the non‐choice experiment. Moreover, the consumption rate of the non‐native slug, D. laeve, was considerably higher than a controphic slug, Meghimatium bilineatum. In the choice experiment, D. laeve preferred lettuce, followed by pumpkin, cabbage, and coriander, even in the presence of detritus and significantly avoided spinach, mint, and basil. The consumption rate of D. laeve had a significant negative correlation with calcium (R = −.49, p = .003) and potassium (R = −.37, p = .03), and a positive correlation was observed for magnesium (R = .37, p = .03). However, no correlation was observed for zinc, silica, total carbohydrate, protein, and phenol content of the leaves. The highest fecundity of D. laeve was observed in the lettuce and cabbage diet, while no eggs were laid on the mint diet. Hence, the consumption of different leaves, irrespective of physical and chemical features (hairiness, amount of silicon, protein, carbohydrate, and phenol), suitable life history traits, and suitable habitats, may facilitate D. laeve as a potential agricultural pest in the Darjeeling Himalayas, India.
Daily‐level simultaneous alcohol and marijuana use and its associations with alcohol use, marijuana use, and negative consequences in a young adult community sample
Authors: Fairlie Anne M. , Calhoun Brian H. , Graupensperger Scott , Patrick Megan E. , Lee Christine M. 
Published: September 2023

AbstractBackgroundSimultaneous alcohol and marijuana (SAM) use has been associated with greater alcohol use and consequences at the daily level, but limited research has examined SAM use in relation to marijuana use and its consequences. This study tested daily associations between SAM use and four outcomes: alcohol use (number of drinks), marijuana use (hours high), negative alcohol consequences, and negative marijuana consequences.MethodsA community sample of young adults [ages 18–25, mean (SD) = 21.61 (2.17) years] with recent alcohol and SAM use was recruited (N = 409; 50.9% female; 48.2% non‐Hispanic/Latinx White). Participants completed a baseline survey and six 2‐week bursts of daily surveys (81.1% of morning surveys completed) and reported on substance use and negative substance‐related consequences. Multilevel modeling was used to test the main aims and to explore each specific consequence.ResultsAmong days with any alcohol use, SAM use days were associated with consuming more drinks and experiencing more total negative alcohol‐related consequences than non‐SAM use days. Among days with any marijuana use, SAM use days were associated with more hours being high than non‐SAM use days. Exploratory models showed that SAM use was related to five specific alcohol‐related consequences and two specific marijuana‐related consequences.ConclusionsThese findings build upon prior research by showing that SAM use days are linked to consuming more drinks, reporting more hours being high from marijuana, and experiencing more total alcohol‐related consequences even after controlling for the number of drinks, the number of hours high, any tobacco/nicotine use, and any other substance use. SAM use was also associated with a greater likelihood of experiencing some specific consequences related to alcohol and marijuana. The findings underscore the need for additional research on SAM use and marijuana‐related outcomes.
The activity‐regulated cytoskeleton‐associated protein, Arc, functions in the nucleus accumbens shell to limit multiple triggers of cocaine‐seeking behaviour
Authors: Barry Sarah M. , Barry Gabriella M. , Martinez Dalia , Penrod Rachel D. , Cowan Christopher W. 
Published: September 2023

AbstractUse of addictive substances like cocaine produces enduring associations between the drug experience and cues in the drug‐taking environment. In individuals with a substance use disorder (SUD) and attempting to remain abstinent, these powerful drug‐cue associations can trigger a return to active drug use, but the molecular mechanisms regulating drug‐cue associations remain poorly understood. The activity‐regulated cytoskeleton‐associated protein (Arc) is induced by cocaine in the nucleus accumbens (NAc), an important brain reward region, but Arc's NAc function in SUD‐related behaviour remains unclear. We show here that cocaine self‐administration (SA) in rats produced a significant upregulation of Arc protein in both the core and shell subregions of the NAc. Subregion‐specific Arc reduction (shRNA) in the medial NAc Shell enhanced both context‐associated and cue‐reinstated cocaine seeking, but without altering the motivation to work for cocaine, the sensitivity to the reinforcing effects of cocaine or the ability of cocaine priming to reinstate drug seeking. In contrast, we observed no effects of Arc knockdown in the NAc core on any aspect of cocaine SA, extinction or reinstated cocaine seeking, suggesting that Arc functions within the medial NAc shell, but not NAc core, to limit the strength of drug‐context and drug‐cue associations that promote cocaine‐seeking behaviour.
What do voters know, and why does it matter? Investigating issue‐specific knowledge and candidate choice in the 2020 U.S. primaries
Authors: Beattie Peter , Milojevich Jovan 
Published: September 2023

AbstractAre differences in issue‐specific knowledge associated with different candidate preferences, as would be expected if voters are judging candidates and their policy commitments on the basis of essential contextual knowledge they receive from the media? By utilizing a bias‐sensitive method of measuring politically relevant knowledge—on economic, foreign policy, and environmental issues—we were able to identify candidate‐selection effects of policy‐specific information. The study also offers new evidence on how psychological traits affect political thinking within a partisan group, whereas most research has focused on psychological asymmetries across ideological and partisan groups. Based on previous research, we expected Sanders supporters and supporters of other “anti‐establishment” candidates to have less accurate knowledge on these issues than Biden (and other establishment candidate) supporters, as the demographic groups that differentially supported Sanders tend to have lower levels of political knowledge. Instead, Sanders and anti‐establishment candidate supporters were found to be more knowledgeable on these issues. We also found psychological asymmetries among Democrats and Democrat‐leaning Independents, which were associated with candidate preference. Overall, issue‐specific political knowledge was found to be an important predictor of vote choice.
L'offre active de services de santé mentale en français en Ontario et au Manitoba : les rôles clés des instruments et des outils
Authors: Cardinal Linda , de Moissac Danielle , Deschênes‐Thériault Guillaume 
Published: September 2023

SommaireCet article présente les données d'un sondage réalisé en 2019 sur la connaissance des gestionnaires et des professionnels œuvrant dans le domaine de la santé mentale en Ontario et au Manitoba de leurs obligations linguistiques et des outils qui favorisent la pratique de l'offre active de services français. L'étude permet de souligner que plus les professionnels et les gestionnaires comprennent leurs obligations, tant en Ontario qu'au Manitoba, plus ils peuvent profiter des outils existants pour s'en acquitter. L'étude montre qu'il existe en effet un lien entre la connaissance des obligations et l'utilisation des outils pour faire de l'offre active de services de santé mentale en français. Elle permet aussi d'insister sur le rôle clé des outils pour faire de l'offre active de services en français.
Anti‐aquaporin‐4 immunoglobulin G/anti‐myelin oligodendrocyte glycoprotein immunoglobulin G double‐positive paraneoplastic neurological syndrome in a patient with triple‐negative breast cancer
Authors: Siddiqui Amna , Ross Dylan , Jani Ronak H. , Prabhu Vikram C. , Lo Shelly , Wainwright Derek A. , Rouse Stasia , Refaat Tamer , Zhu Yirong , Thakkar Jigisha P. 
Published: September 2023

AbstractWe report a rare case of paraneoplastic neurological syndrome with dual seropositivity of anti‐aquaporin‐4 and myelin oligodendrocyte glycoprotein antibodies in a 40 year‐old woman with metastatic triple‐negative breast cancer. She received multiple lines of anti‐neoplastic treatment, including immunotherapy with pembrolizumab, as well as cytotoxic chemotherapy. Paraneoplastic meningoencephalomyelitis developed 2 years after diagnosis of breast cancer and 1 year after discontinuation of immunotherapy with pembrolizumab. She first developed longitudinally extending transverse myelitis followed by left optic neuritis and meningoencephalitis with new enhancing lesions in the brain and spinal leptomeninges. Cerebrospinal fluid analysis during both episodes showed normal glucose and protein, and elevated white blood cell count. Cytology was negative for malignancy. Cerebrospinal fluid was positive for neuromyelitis optica immunoglobulin G antibody anti‐aquaporin‐4, and autoimmune myelopathy panel was positive for myelin oligodendrocyte glycoprotein antibody. The patient had significant clinical and radiographic improvement after completion of five cycles of plasmapheresis followed by intravenous immunoglobulin. She did not have recurrence of paraneoplastic syndrome with maintenance rituximab every 6 months and daily low‐dose prednisone. She succumbed to progressive systemic metastatic disease 4.5 years after her breast cancer diagnosis. This case shows that these antibodies can occur concurrently and cause clinical features, such as both neuromyelitis optica spectrum disorder and myelin oligodendrocyte glycoprotein antibody disease, in a patient with a singular type of cancer. We highlight the importance of testing for paraneoplastic etiology in cancer patients with radiographic menigoencephalomyelitis or meningitis with atypical symptoms of meningeal carcinomatosis and/or cerebrospinal fluid profile negative for leptomeningeal carcinomatosis.
miR135a administration ameliorates brain ischemic damage by preventing TRPM7 activation during brain ischemia
Authors: Cepparulo P. , Brancaccio P. , Sirabella R. , Anzilotti S. , Guida N. , Laudati G. , Valsecchi V. , Vinciguerra A. , Viscardi V. , D'Esposito L. , Formisano L. , Annunziato L. , Pignataro G. , Cuomo O. 
Published: September 2023

AbstractBackgroundmiRNA‐based strategies have recently emerged as a promising therapeutic approach in several neurodegenerative diseases. Unregulated cation influx is implicated in several cellular mechanisms underlying neural cell death during ischemia. The brain constitutively active isoform of transient receptor potential melastatin 7 (TRPM7) represents a glutamate excitotoxicity‐independent pathway that significantly contributes to the pathological Ca2+ overload during ischemia.AimsIn the light of these premises, inhibition of TRPM7 may be a reasonable strategy to reduce ischemic injury. Since TRPM7 is a putative target of miRNA135a, the aim of the present paper was to evaluate the role played by miRNA135a in cerebral ischemia. Therefore, the specific objectives of the present paper were: (1) to evaluate miR135a expression in temporoparietal cortex of ischemic rats; (2) to investigate the effect of the intracerebroventricular (icv) infusion of miR135a on ischemic damage and neurological functions; and (3) to verify whether miR135a effects may be mediated by an alteration of TRPM7 expression.MethodsmiR135a expression was evaluated by RT‐ PCR and FISH assay in temporoparietal cortex of ischemic rats. Ischemic volume and neurological functions were determined in rats subjected to transient middle cerebral artery occlusion (tMCAo) after miR135a intracerebroventricular perfusion. Target analysis was performed by Western blot.ResultsOur results demonstrated that, in brain cortex, 72 h after ischemia, miR135a expression increased, while TRPM7 expression was parallelly downregulated. Interestingly, miR135a icv perfusion strongly ameliorated the ischemic damage and improved neurological functions, and downregulated TRPM7 protein levels.ConclusionsThe early prevention of TRPM7 activation is protective during brain ischemia.
VIRMA promotes neuron apoptosis via inducing m6A methylation of STK10 in spinal cord injury animal models
Authors: Hong Hongxiang , Xu Guanhua , Bao Guofeng , Zhang Jinlong , Chen Chu , Chen Jiajia , Wu Chunshuai , Jiang Jiawei , Huang Jiayi , Huang Haiming , Cui Zhiming 
Published: September 2023

AbstractBackgroundSpinal cord injury (SCI) occurs as a devastating neuropathic disease. The role of serine–threonine kinase 10 (STK10) in the development of SCI remains unclear.ObjectiveThis study aimed to investigate the action of m6A methylation on STK10 in the apoptosis of spinal cord neurons in the pathogenesis of SCI and the possible underlying mechanisms.MethodsRat model of SCI was established and subsequently evaluated for motor function, pathological conditions, and apoptosis of spinal cord neurons. And the effects of overexpression of STK10 on neuronal cells in animal models of spinal cord injury and glyoxylate deprivation (OGD) cell models were evaluated. m6A2Target database and SRAMP database were used to predict the m6A methylation sites of STK10. The methylation kits were used to detect overall m6A methylation. Finally, the interaction between STK10 and vir like m6A methyltransferase associated (VIRMA) was explored in animal and cellular models.ResultsSTK10 is markedly decreased in spinal cord injury models and overexpression of STK10 inhibits neuronal apoptosis. VIRMA can induce m6A methylation of STK10. VIRMA is over‐expressed in spinal cord injury models and negatively regulates the expression of STK10. m6A methylation and apoptosis of neuronal cells are reduced by the knockdown of VIRMA and STK10 shRNA have shown the opposite effects.ConclusionsVIRMA promotes neuronal apoptosis in spinal cord injury by regulating STK10 m6A methylation.
Investigation of dyeing, antibacterial and antifungal properties of blended fabrics treated with plant‐based dyestuffs and mordants as shoe materials
Authors: Sabyrkhanova Saltanat , Ork Efendioglu Nilay , Yeldiyar Gulzinat , Bitlisli Behzat Oral 
Published: September 2023

AbstractIn this research article, it is reported the preparation and characterisation of four types of blended cotton‐polyester based textile materials in different dye ratios with four kinds of natural dyes of agro waste (walnut shell, onion peel) and wildflowers (tansy, Hypericum) with/without mordants as antibacterial and antifungal species for shoe materials. The dyed samples were spectrophotometrically measured and the results were obtained as colour strength (K/S) as well as CIELab values. As a result, dyed fabrics with natural dyes showed yellow, grey, orange and brown colours. With the help of a mordant, aluminium‐potassium, the dyed fabrics obtained natural, not distorted shades of these colours, and with the addition of copper sulphate, they showed changing yellow to light green, orange to dark red, grey to a darker shade of grey and brown to a darker colour. The dyed samples were tested for colour fastness to circle rubbing and satisfactory results were found. The fabrics dyed only with natural dyes and treated with natural dye and mordants were evaluated for antibacterial and antifungal properties against Escherichia coli, Staphylococcus aureus, and Candida albicans. The results indicated that fabrics treated with these natural dyes and mordants had excellent antibacterial and antifungal activity. All natural dyes and mordants used in this study were the most effective and showed the maximum inhibition zone, indicating the best antimicrobial and antifungal activity against tested microbes. The results showed that all these natural dyes can provide some antibacterial and antifungal activity on mixed fabrics.
Primary cutaneous apocrine carcinoma, arising in tubular apocrine adenoma
Authors: Griffith MacKenzie , Singh Raj , Alabkaa Anas , Reddy Vijaya , Ahmed Aadil 
Published: September 2023

AbstractPrimary cutaneous apocrine carcinoma is a rare adnexal tumor that arises from apocrine progenitor cells. These tumors may be associated with benign apocrine hyperplasia, and a longstanding history of a lesion should not preclude a malignant diagnosis. We report a case of a 70‐year‐old female who presented to the clinic with a 3‐year history of an asymptomatic vulvar lesion. An excisional biopsy was performed. Histopathologic examination revealed a tumor with two distinct components. The first component was determined to be a benign tubular apocrine adenoma. The second component, arising within the apocrine adenoma, was determined to be an apocrine carcinoma based on histopathologic features and immunohistochemical profile. Twelve months after subsequent wide local excision and sentinel node biopsy, the patient is alive without recurrence.
The response to fire by two eusocial bee species
Authors: Nakas Georgios , Lazarina Maria , Chtenelli Taxiarchoula‐Tzoanna , Sgardelis Stefanos , Dimitrakopoulos Panayiotis G. , Devalez Jelle , Petanidou Theodora 
Published: September 2023

Abstract
Fire is a common worldwide disturbance that affected the evolution of life and shaped plant and animal diversity; this is especially applicable in the Mediterranean.
In this study, we explore the response to fire of two eusocial bee species of Halictidae, namely, Lasioglossum marginatum (Brullé, 1832) and Lasioglossum malachurum (Kirby, 1802), as to their population number, body size and pollination specialisation.
The study was carried out on Chios Island, Greece, during the first 3 years after a wildfire (2013–2015). Fire effect was examined from a spatial viewpoint by comparing unburnt with burnt sites and from a temporal one by comparing populations among different postfire years.
We found that L. malachurum populations increased with time after fire, while they were more abundant in the burnt sites during the second postfire year. In contrast, L. marginatum populations decreased in both burnt and unburnt sites, which suggests that the decline was not an effect of the fire alone.
Insect body size differed among years for both species, with L. marginatum individuals being smaller in the burnt sites compared to the unburnt, albeit only in the first postfire year. Finally, both species show high partner fidelity but to different plant partners.
Our results underscore the importance of studies focusing on the effects of a disturbance at the intraspecific level. However long‐term monitoring is required, especially in the context of the global pollinator crisis and the more frequent and severe wildfires as an effect of climate change.