bluuebunny/crossref_metadata_2025_split huggingface dataset:
Structural damage identification based on pattern matching using the flexibility change rate
Authors: Nie Zhenhua , Chen Tao , Xia Guanghao , Li Zuanfeng , Gao Ruofan , Ma Hongwei 
Published: March 2023

AbstractIn this paper, a rapid identification method for postearthquake structural damage is proposed based on pattern matching using the flexibility change rate. In the first stage, a small number of dynamic signals are collected for extracting the modal information, which is used as a reference for model updating. Using the updated finite element model of the structure to be monitored, the characteristic vector of the flexibility change rate is calculated by modal analysis from the first two orders of modal information of various damage scenarios to establish a pattern database. For the real structure, the measured responses are used to identify the modal parameters to calculate the flexibility change rate characteristic vector, which is treated as the observed pattern. Then, the similarity between the observed pattern and the pattern in the pattern database is calculated using the Euclidean distance (ED). The damage location and severity of the measured structure are treated to be the same as the pattern corresponding to the minimum value of ED, so that the damage is identified. Numerical simulations and experiments of two types of concentrated mass structures, four floors, and six floors confirm that the proposed method can identify the damage well. In addition, the matching results based on different sensor combinations demonstrate that the method can quickly identify the damage location and severity of a structure even using a limited number of sensors. The proposed method can provide support for the government in rapid postearthquake emergency decision‐making.
Fibroblastic reticular cells provide a supportive niche for lymph node–resident macrophages
Authors: D'Rozario Joshua , Knoblich Konstantin , Lütge Mechthild , Shibayama Christian Pérez , Cheng Hung‐Wei , Alexandre Yannick O. , Roberts David , Campos Joana , Dutton Emma E. , Suliman Muath , Denton Alice E. , Turley Shannon J. , Boyd Richard L. , Mueller Scott N. , Ludewig Burkhard , Heng Tracy S.P. , Fletcher Anne L. 
Published: March 2023

AbstractThe lymph node (LN) is home to resident macrophage populations that are essential for immune function and homeostasis, but key factors controlling this niche are undefined. Here, we show that fibroblastic reticular cells (FRCs) are an essential component of the LN macrophage niche. Genetic ablation of FRCs caused rapid loss of macrophages and monocytes from LNs across two in vivo models. Macrophages co‐localized with FRCs in human LNs, and murine single‐cell RNA‐sequencing revealed that FRC subsets broadly expressed master macrophage regulator CSF1. Functional assays containing purified FRCs and monocytes showed that CSF1R signaling was sufficient to support macrophage development. These effects were conserved between mouse and human systems. These data indicate an important role for FRCs in maintaining the LN parenchymal macrophage niche.
Photosensitive occipital lobe epilepsy: Delineation of an under‐recognized reflex epilepsy syndrome according to the new ILAE criteria and long‐term follow‐up
Authors: Cerrahoğlu Şirin Tuba , Yılmaz Tülay , Elmalı Ayşe Deniz , Bebek Nerses , Demirbilek Veysi , Baykan Betül 
Published: March 2023

AbstractObjectivePhotosensitive occipital lobe epilepsy (POLE) should be suspected in patients with occipital lobe seizures triggered by photic stimuli, who have normal motor‐mental development and brain imaging. We aimed to examine the clinical, electrophysiological, and prognostic features of POLE, which is a rare and under‐investigated syndrome.MethodsArchives from two tertiary epilepsy centers were retrospectively scanned and patients with normal neurological examination and cranial imaging were identified with POLE if they had: (1) seizures consistently triggered by photic stimuli; (2) non‐motor seizures with visual symptoms; and (3) photosensitivity documented on EEG. The clinical and electrophysiological features and prognostic factors were evaluated for patients who had follow‐up ≥5 years.ResultsWe identified 29 patients diagnosed with POLE with a mean age of 20.1 ± 7.6 years. In one‐third of the patients, POLE syndrome overlapped with genetic generalized epilepsy (GGE). The overlap group had higher rates of febrile seizure history and self‐induction; when compared to pure POLE patients, their EEGs showed more frequent interictal generalized epileptic discharges and posterior multiple spikes during intermittent photic stimulation. During long‐term follow‐up, the remission rate for POLE was 80%, but EEG photosensitivity persisted in three quarters of patients despite clinical remission, and more than half had relapsed after clinical remission.SignificanceThis first long‐term follow‐up study, utilizing newly suggested criteria of the International League Against Epilepsy, showed that POLE syndrome shows a notable overlap with GGE but also has distinctive features. POLE has a good prognosis; however, relapses are common, and photosensitivity persists as an EEG finding in the majority of patients.
Genomic landscape of follicular lymphoma across a wide spectrum of clinical behaviors
Authors: Mozas Pablo , López Cristina , Grau Marta , Nadeu Ferran , Clot Guillem , Valle Sara , Kulis Marta , Navarro Alba , Ramis‐Zaldivar Joan Enric , González‐Farré Blanca , Rivas‐Delgado Alfredo , Rivero Andrea , Frigola Gerard , Balagué Olga , Giné Eva , Delgado Julio , Villamor Neus , Matutes Estella , Magnano Laura , García‐Sanz Ramón , Huet Sarah , Russell Robert B. , Campo Elías , López‐Guillermo Armando , Beà Sílvia 
Published: March 2023

AbstractWhile some follicular lymphoma (FL) patients do not require treatment or experience prolonged responses, others relapse early, and little is known about genetic alterations specific to patients with a particular clinical behavior. We selected 56 grade 1–3A FL patients according to their need of treatment or timing of relapse: never treated (n = 7), non‐relapsed (19), late relapse (14), early relapse or POD24 (11), and primary refractory (5). We analyzed 56 diagnostic and 12 paired relapse lymphoid tissue biopsies and performed copy number alteration (CNA) analysis and next generation sequencing (NGS). We identified six focal driver losses (1p36.32, 6p21.32, 6q14.1, 6q23.3, 9p21.3, 10q23.33) and 1p36.33 copy‐neutral loss of heterozygosity (CN‐LOH). By integrating CNA and NGS results, the most frequently altered genes/regions were KMT2D (79%), CREBBP (67%), TNFRSF14 (46%) and BCL2 (40%). Although we found that mutations in PIM1, FOXO1 and TMEM30A were associated with an adverse clinical behavior, definitive conclusions cannot be drawn, due to the small sample size. We identified common precursor cells harboring early oncogenic alterations of the KMT2D, CREBBP, TNFRSF14 and EP300 genes and 16p13.3‐p13.2 CN‐LOH. Finally, we established the functional consequences of mutations by means of protein modeling (CD79B, PLCG2, PIM1, MCL1 and IRF8). These data expand the knowledge on the genomics behind the heterogeneous FL population and, upon replication in larger cohorts, could contribute to risk stratification and the development of targeted therapies.
Reduction in thrombolytic order‐to‐needle time with addition of a pharmacist to a pulmonary embolism response team
Authors: Berdahl Gideon J. , Cascone Ava E. , Ackerbauer Kimberly A. , Feeney Megan E. 
Published: March 2023

AbstractIntroductionPulmonary embolism (PE) is the third most common cause of cardiovascular death in the United States. Institutions have implemented pulmonary embolism response teams (PERT) to hasten clinical decision making and therapeutic interventions. The extent to which critical care pharmacists are included in PERTs is not known. Although improved outcomes with pharmacist involvement in other emergency response teams (e.g., stroke teams) is well described, literature surrounding the impact of pharmacist inclusion in PERTs is limited. The objective was to evaluate if direct pharmacist inclusion in a PERT resulted in reduced time to systemic thrombolysis from time of medication order release in appropriate PE candidates.MethodsThis was a retrospective, observational study of patients with submassive or massive PE who received systemic thrombolysis at a large academic medical center. Patients were divided into two groups based on if they received systemic thrombolysis before or after the intervention. This intervention was the addition of a pharmacist to the PERT with emphasis on early communication between the PERT pharmacist and other stakeholders at time of PERT activation, and a revised thrombolytic preparation workflow emphasizing bedside preparation by the pharmacist. The primary outcome was time to administration of thrombolytic from time of medication order release.ResultsThirty‐four patients were included. Median time to thrombolytic administration was reduced in the post‐intervention group compared to the pre‐intervention group (23 min [14.8–42] vs. 54 min [42.8–69], p = 0.007). Bleeding events were not different between groups. Time to resumption of systemic anticoagulation after systemic thrombolysis was greater in the post‐intervention group.ConclusionInclusion of a pharmacist in the PERT at this institution significantly reduced time to administration of systemic thrombolysis from time of medication order release in appropriate PE candidates. Larger studies should be conducted to expand upon and confirm these findings.
When can we ignore measurement error in the running variable?
Authors: Dong Yingying , Kolesár Michal 
Published: March 2023

SummaryIn many applications of regression discontinuity designs, the running variable used to assign treatment is only observed with error. We show that, provided the observed running variable (i) correctly classifies treatment assignment and (ii) affects the conditional means of potential outcomes smoothly, ignoring the measurement error nonetheless yields an estimate with a causal interpretation: the average treatment effect for units whose observed running variable equals the cutoff. Possibly after doughnut trimming, these assumptions accommodate a variety of settings where support of the measurement error is not too wide. An empirical application illustrates the results for both sharp and fuzzy designs.
Heavy metal‐free electrochemical detection of pyrophosphate ions by Nafion/carbon dots decorated screen printed carbon electrodes
Authors: Chang Che‐Wei , Liao Wei‐Ssu 
Published: March 2023

AbstractWe employ Nafion‐mixed carbon dots (CDs) and low‐cost screen‐printed carbon electrodes (SPCEs) as foundation matrices for the fabrication of electrochemical biosensors. The NH2 and COOH functional groups present on the SPCE surface after Nafion/CDs deposition allow for pyrophosphate ions (PPis) collection. Using Fe(CN)63− as the electrochemical mediator, the SPCE‐Nafion/CDs are applied to the detection of aqueous PPi by square wave voltammetry. Between 50 and 1 μM, a linear connection is established between the square wave voltammetry current and the PPi concentration. The limit of detection is determined to be 1.01 μM, and recoveries of 113% (±1.9%) and 108% (±3.9%) are achieved for human urine samples spiked with 6 and 3 μM of PPi, respectively. Furthermore, this PPi assay is suitable for the usage of complicated urine matrices without the inclusion of heavy metals. We anticipate that this unique approach will be beneficial for PPi level monitoring in urine during therapeutic treatments of illnesses and malignancies.
The effects of COVID‐19 on child mental health: Biannual assessments up to April 2022 in a clinical and two general population samples
Authors: Zijlmans Josjan , Tieskens Jacintha M. , van Oers Hedy A. , Alrouh Hekmat , Luijten Michiel A. J. , de Groot Rowdy , van der Doelen Daniël , Klip Helen , van der Lans Rikkert M. , de Meyer Ronald , van der Mheen Malindi , Ruisch I. Hyun , van den Berg Germie , Bruining Hilgo , Buitelaar Jan , van der Rijken Rachel , Hoekstra Pieter J. , Kleinjan Marloes , Lindauer Ramón J. L. , Oostrom Kim J. , Staal Wouter , Vermeiren Robert , Cornet Ronald , Haverman Lotte , Popma Arne , Bartels Meike , Polderman Tinca J. C. 
Published: March 2023

AbstractBackgroundThe COVID‐19 pandemic has had an acute impact on child mental and social health, but long‐term effects are still unclear. We examined how child mental health has developed since the start of the COVID‐19 pandemic up to 2 years into the pandemic (April 2022).MethodsWe included children (age 8–18) from two general population samples (N = 222–1333 per measurement and N = 2401–13,362 for pre‐covid data) and one clinical sample receiving psychiatric care (N = 334–748). Behavioral questionnaire data were assessed five times from April 2020 till April 2022 and pre‐pandemic data were available for both general population samples. We collected parent‐reported data on internalizing and externalizing problems with the Brief Problem Monitor and self‐reported data on Anxiety, Depressive symptoms, Sleep‐related impairments, Anger, Global health, and Peer relations with the Patient‐Reported Outcomes Measurement Information System (PROMIS®).ResultsIn all samples, parents reported overall increased internalizing problems, but no increases in externalizing problems, in their children. Children from the general population self‐reported increased mental health problems from before to during the pandemic on all six PROMIS domains, with generally worst scores in April 2021, and scores improving toward April 2022 but not to pre‐pandemic norms. Children from the clinical sample reported increased mental health problems throughout the pandemic, with generally worst scores in April 2021 or April 2022 and no improvement. We found evidence of minor age effects and no sex effects.ConclusionsChild mental health in the general population has deteriorated during the first phase of the COVID‐19 pandemic, has improved since April 2021, but has not yet returned to pre‐pandemic levels. Children in psychiatric care show worsening of mental health problems during the pandemic, which has not improved since. Changes in child mental health should be monitored comprehensively to inform health care and policy.
Enumeration of spanning trees of complete multipartite graphs containing a fixed spanning forest
Authors: Li Danyi , Chen Wuxian , Yan Weigen 
Published: March 2023

AbstractMoon's classical result implies that the number of spanning trees of a complete graph with vertices containing a given spanning forest equals , where is the number of components of , and are the numbers of vertices of component of . Dong and Ge extended this result to the complete bipartite graph, and obtain an interesting formula to count spanning trees of a complete bipartite graph containing a given spanning forest . They also posed the problem to count spanning trees of a complete ‐partite graph containing a given spanning forest for . In this paper, we propose a technique to solve this problem. Using this technique, we obtain closed formulae to count spanning trees of complete ‐partite graphs containing a given spanning forest for and 4. Our technique also results in a new and simple proof of Dong and Ge's formula.
C5 ${C}_{5}$ is almost a fractalizer
Authors: Lidický Bernard , Mattes Connor , Pfender Florian 
Published: March 2023

AbstractWe determine the maximum number of induced copies of a 5‐cycle in a graph on vertices for every . Every extremal construction is a balanced iterated blow‐up of the 5‐cycle with the possible exception of the smallest level where for , the Möbius ladder achieves the same number of induced 5‐cycles as the blow‐up of a 5‐cycle on eight vertices. This result completes the work of Balogh, Hu, Lidický, and Pfender, who proved an asymptotic version of the result. Similarly to their result, we also use the flag algebra method, but we use a new and more sophisticated approach which allows us to extend its use to small graphs.
Comparison of clinical manifestations in mpox patients living with HIV versus without HIV: A systematic review and meta‐analysis
Authors: Shin Hyoin , Shin Heeje , Rahmati Masoud , Koyanagi Ai , Jacob Louis , Smith Lee , Rhee Sang Youl , Kwon Rosie , Kim Min Seo , Kim Sunyoung , Il Shin Jae , Min Chanyang , Cho Wonyoung , Yon Dong Keon 
Published: March 2023

AbstractCurrently, many cases of mpox patients living with the human immunodeficiency virus (HIV) have been reported. Immunocompromised mpox patients, including those living with HIV are noted for an increased risk for severe symptoms; however, existing studies did not focus on the statistical comparison of mpox outcomes associated with HIV. Thus, we conducted a systematic review and meta‐analysis to evaluate and compare the clinical manifestations of mpox in people living with HIV (PLWH) and people without HIV. In this systematic review and meta‐analysis, PubMed/MEDLINE, Embase, and Google Scholar were searched up to March 7, 2023. A random effects model was used to calculate the pooled prevalence along with the 95% confidence intervals (CI), and the odds ratio and its corresponding 95% CIs were calculated to elucidate the significance of each clinical feature for mpox patients with and without HIV. In this study, we included 99 published papers with 2413 patients with mpox (median age, 35.5 years; PLWH n = 1151) from 27 countries across six continents. The odds ratio of the mpox outcomes with PLWH in comparison to patients without HIV was found to be significant for skin rash (1.24, 95% CI: 1.01–1.53), proctitis (2.03, 95% CI: 1.36–3.04), cough (0.57, 95% CI: 0.33–0.98), and diarrhea (3.85, 95% CI: 1.24–11.98). The odds ratio of mpox patients with HIV for historical infections of syphilis was 2.14 (95% CI: 1.38–3.32), compared with those without HIV. This is the first international and comprehensive study that performed a systematic review and meta‐analysis to statistically measure mpox manifestations according to HIV status. As clinical features related to mucosal contact were characteristically pronounced in PLWH, our systematic review provides insight that the primary invasion site of infection strongly relates to the outcomes of mpox.
Holographic waveguide display with large field of view based on volume holographic grating
Authors: Wang Chuang , Zhang Yuning , Weng Yishi , Shen Zhongwen , Wei Ran , Gu Yuchen , Zhang Lixuan 
Published: March 2023

AbstractThe field of view (FOV) of waveguide display systems based on volume holographic grating (VHG) is primarily constrained by the diffraction response bandwidth, which is currently insufficient to meet the need for AR immersive displays. Through the composite diffraction response bandwidths, red‐responsive and green‐responsive double‐layer VHG structures are proposed to expand the FOV under varied image sources. The influence of several input spectral bandwidths on FOV improvement is also considered, and OLED micro‐display and LCOS micro‐display are selected as image sources. As a consequence, the horizontal FOV of the red‐responsive double‐layer VHG waveguide based on the LCOS micro‐display is 19.5°, and that of the green‐responsive double‐layer VHG waveguide based on the OLED micro‐display is 33.4°. Through the simulation and experiment, we effectively illustrate the effect of the double‐layer VHG and the input spectral bandwidth on the FOV.
Authentic omnichannel: Providing consumers with a seamless brand experience through authenticity
Authors: Massi Marta , Piancatelli Chiara , Vocino Andrea 
Published: March 2023

AbstractOmnichannel represents a customer‐oriented distribution paradigm through which retailers can deliver a seamless customer experience and create an authentic brand narrative that is communicated to customers across diverse touchpoints. Despite the increasing relevance of the omnichannel approach, research on how omnichannel can affect the customer experience remains scant. This research consists of a qualitative study and three experimental studies. Drawing from signaling theory, we contend that the signal congruency established by omnichannel—where all the channels are aligned and convey a consistent message to customers—can enhance consumers' purchase intention and perceptions of brand authenticity. We further investigate the role of brand authenticity as a mediator of the relationship between multichannel customer experience (seamless vs. nonseamless) and purchase intention, as well as of brand untrustworthiness as a moderator of the relationship between multichannel customer experience and brand authenticity. The results show that a seamless multichannel customer experience has a significant main effect on purchase intention and that participants in the seamless multichannel customer experience condition perceive the brand as more authentic than those in the nonseamless multichannel customer experience condition. Both the mediation and moderation hypotheses are supported. These findings enhance the literature on signaling theory and omnichannel. They also provide insightful implications for retailers in terms of managing the omnichannel customer experience. Overall, this study integrates the research areas of brand authenticity and omnichannel and provides valuable insights by indicating how seamlessness can boost consumers' perception of brand authenticity. Furthermore, the study advances our knowledge by investigating the impact of brand authenticity as both a result of the omnichannel customer experience and a predictor of purchase intention.
Characterization and quantification of oxidative stress induced particle debris from polypropylene surgical mesh
Authors: Farr Nicholas T. H. , Rauert Cassandra , Knight Alexander J. , Tartakovskii Alexander I. , Thomas Kevin V. 
Published: March 2023

AbstractExplanted polypropylene (PP) surgical mesh has frequently been reported to show surface alterations, such as cracks and flaking. However, to date the consequence of PP mesh degradation is not clearly understood, particularly its potential to influence the biological host response of surrounding tissues. Of particular concern is a possible host reaction to polypropylene particles released through degradation of surgical mesh in vivo. This concern is driven by previous studies which have postulated that an oxidative stress environment has the potential to etch away particles from the surface of a PP fibers. The release of such particles is of considerable significance as particles in the nano‐ to micro range have been shown to have the capacity to irritate cells and stimulate the immune system. The authors are not aware of any previous studies that have attempted to characterize, quantify or identify any particles released from PP mesh after exposure to an oxidative stress environment. Characterization of the PP mesh, post oxidative stress exposure, including identification of particles was achieved through application of a range of techniques: low voltage‐scanning electron microscopy (LV‐SEM), pyrolysis gas chromatography mass spectrometry (Pyr‐GCMS), nano‐Fourier transform infrared spectroscopy (nano‐FTIR), scattering‐type, scanning near‐field optical microscopy (s‐SNOM), atomic force microscopy (AFM), attenuated total reflectance‐Fourier transform infrared spectroscopy (ATR‐FTIR) and uniaxial tensile testing. The findings of this study indicate that oxidative stress alone is a major factor in the production of PP particle debris. PP debris identified within solution, using Pyr‐GCMS, was shown to be in order of the micron scale.