bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preparation and performance of grinding wheel with orderly arranged abrasive particles based on laser processing technology
Authors: Li Kangwei , Zhang Mingjun , Zhang Jian , Mao Cong , Dai Longzhou , Zhang Yun , Zhang Yan , Bi Zhuming , Tang Kun , Hu Yongle 
Published: February 2023

Abstract
Laser processing has its advantages of high energy density, good controllability and high flexibility; it has shown its importance in advancing modern manufacturing. Laser processing is used in this paper to fabricate an end grinding wheel with orderly arranged abrasive particles, and the performance of the fabricated grinding wheel is compared with that of a conventional grinding wheel. Our experiment and comparative studies have drawn the conclusions of (1) active laser brazing has been successfully used to arrange diamond particles in Archimedes’ spirals; (2) the resulted grinding wheel has shown the enhanced effectiveness in comparison with the conventional grinding wheel in terms of reduced grinding force; when the spiral change rate i is set 0.25, the tangential grinding force has been reduced by up to 60%; (3) for a grinding wheel with specific spiral change rate, ground debris are discharged from the grinding zone in a certain direction, and the grinding temperature can be reduced; (4) in high-speed grinding, the surface quality by the grinding wheel with orderly arranged abrasive particles is better than that of conventional grinding wheel; under the tested grinding conditions, the roughness of the ground surface has been reduced up to 47% of that by conventional grinding wheels; (5) the grinding wheel with orderly arranged abrasive particles has shown the better wear-resistance that conventional grinding wheels; abrasive particles of all four conventional grinding wheels are damaged to certain extent but orderly arranged abrasive particles on the fabricated wheel maintain mostly their protruded heights.
Analysis of Muti-agent low-carbon behavioral strategies in the construction industry: An Evolutionary Game based on Prospect Theory
Authors: Duan Jiajun , Wang Yousong , Zhang Yangbing 
Published: February 2023

Abstract
As a major energy consumption sector in China, the construction industry has been a hot spot of concern regarding carbon reduction. The local governments have launched various policies to promote low-carbon production. However, the response of different parties is still confusing. Thus, based on prospect theory, this paper investigated the relationship among government policy intervention, enterprises’ production strategies and consumers’ purchasing behavior. Then, a tripartite evolutionary game model was established and a case study was applied to simulate the model. The results show that: 1) government subsidies and penalties can directly influence the strategy of each party, but excessive supervision costs can also be counterproductive to policy intervention; 2) corporate revenue and technical costs are also the main drivers affecting the low-carbon strategies of construction enterprises; 3) enhancing consumers’ environmental preference or awareness is also an effective way to promote low-carbon production. The findings are valuable for governments to further realize related parties’ responses to different policies and make appropriate development for low-carbon construction.
Virtual Element Method for nonlinear Sobolev equation on Polygonal Meshes
Authors: Liu Wanxiang , Chen Yanping , Gu Qiling , Huang Yunqing 
Published: February 2023

Abstract
In this work, the virtual element method (VEM) on convex polygonal meshes for the Sobolev equations is developed, where the semi-discrete and fully discrete formulations are presented and analysed. To overcome the complexity of nonlinear terms, the nonlinear coefficient is approximated by employing the orthogonal L2 projection operator, which is directly computable from the degrees of freedom. Under some assumptions about the nonlinear coefficient, the existence and uniqueness of the semi-discrete solution are analyzed. Furthermore, a priori error estimate showing optimal order of convergence with respect to the H1 semi-norm was derived. Finally, some numerical experiments are conducted to illustrate the theoretical convergence rate.
The auxiliary effects of low-molecular-weight fucoidan on the quality of life for locally advanced rectal cancer patients receiving neoadjuvant concurrent chemoradiotherapy before surgery: A double-blind, randomized, placebo- controlled study
Authors: Tsai Hsiang-Lin , Yeh Yung-Sung , Chen Po-Jung , Chang Yu-Tang , Chen Yen-Cheng , Li Ching-Chun , Su Wei-Chih , Chang Tsung-Kun , Huang Ching-Wen , Wang Jaw-Yuan 
Published: February 2023

Abstract
Background
Patients with cancer use low-molecular-weight fucoidan (LMF) as a supplement to therapy. However, most studies of LMF are in vitro or conducted using animals. Concurrent chemoradiotherapy (CCRT) is the gold standard for locally advanced rectal cancer (LARC). This study investigated the quality of life and clinical outcomes of patients with LARC taking LMF as a supplement to neoadjuvant CCRT before surgery.
Methods
This was a double-blind, randomized, placebo-controlled study. The sample comprised 87 patients, of whom 44 were included in a fucoidan group and 43 were included in a placebo group. We compared their scores of the quality of life and clinical outcomes before treatment, and at 1 month, 2 months, and 3 months posttreatment. Pretreatment and posttreatment gut microbiota differences were also compared.
Results
Although the enhanced quality of the life was observed in the fucoidan group at 2 months and 3 months posttreatment (both P < 0.05), the efficacies were nonsignificant (all P > 0.05). Skin rash and itching and fatigue were less common in the fucoidan group (both P < 0.05). Posttreatment, the genus Parabacteroides was significantly more common in the gut microbiota of the fucoidan group (P = 0.015).
Conclusions
LMF administration improved the quality of life, skin rash and itching, fatigue, and gut microbiota composition of the patients with LARC receiving CCRT.
Computed Tomographic Analysis of Frontal Recess Cell Prevalence According to International Frontal Sinus Anatomy Classification
Authors: Yaylacı Atılay , Değer Hasan Mervan 
Published: February 2023

Abstract
Purpose
The frontal recess (FR) has a complex anatomy composed of a number of cells that dictate the frontal sinus drainage pathway. The International Frontal Sinus Anatomy Classification (IFAC) is a new system for classifying FR cells. This study investigated the prevalence and symmetry of IFAC cells in healthy sinuses and assessed the interrater agreement of IFAC cells.
Methods
509 adult patients with non-diseased paranasal sinuses were included in this retrospective cross-sectional study. Two rhinologists independently identified IFAC cells on 1018 sides using triplanar CT reconstructions. The prevalence of each cell type was assessed, and interobserver agreement was measured using the kappa coefficient (κ).
Results
The prevalence of FR cells varied, with the agger nasi cell (ANC) being the most prevalent at 88.0% and the supra bulla frontal cell (SBFC) being the least prevalent at 7.1%. FR cells that pneumatize into the frontal sinus were identified in 28.6% of the FRs, with male patients having a significantly higher prevalence than female patients. The ANC had the highest bilateral incidence at 80.4%, while the SBFC had the lowest at 2.2%. All IFAC cells had excellent interrater agreement, with κ values ranging from 0.94 to 1.0.
Conclusion
The prevalence of FR cells varies among populations. Male patients were more likely to have FR cells that pneumatize across the frontal sinus. These results highlight the importance of considering population- and gender- specific prevalence rates of individual FR cells in endoscopic sinus surgery planning. IFAC is a reliable tool for identifying cells in the FR with a high level of interrater agreement.
Remnant liver function is associated with long-term survival in patients with hepatocellular carcinoma undergoing hepatectomy
Authors: Miki Atsushi , Sakuma Yasunaru , Watanabe Jun , Endo Kazuhiro , Sasanuma Hideki , Teratani Takumi , Lefor Alan Kawarai , Shimizu Atsushi , Kitayama Joji , Yasuda Yoshikazu , Sata Naohiro 
Published: February 2023

Abstract
Purpose
It is important to assess the prognosis and intervene before and after surgery in patients with hepatocellular carcinoma. This study aims to elucidate the association of outcomes and residual liver function after hepatectomy.
Methods
A total of 176 patients who underwent the initial resection for hepatocellular carcinoma between January 2011 and March 2021 at Jichi Medical University were included. Hepatic clearance of the remnant liver was measured using 99mTc-galactosyl serum albumin scintigraphy. The log-rank test was used to analyze survival using the Kaplan-Meier method. Hazard ratios (HR) and 95% confidence intervals (CI) for overall survival were calculated using Cox’s proportional hazard model.
Results
In multivariate analysis, microvascular invasion (HR 2.34, P = 0.0327, 95%CI 1.072–5.117), intraoperative blood loss (HR 2.27, P = 0.0313, 95%CI 1.077–4.797), and hepatic clearance of the remnant liver (HR 0.48, P = 0.0174, 95%CI 0.266–0.880) were independently associated with overall survival. Hepatic clearance of the remnant liver (HR 0.63, P = 0.0398, 95%CI 0.411–0.979) was independently associated with recurrence free survival.
Conclusions
This is the first report to show that lower residual liver function is associated with shorter survival in patients with hepatocellular carcinoma undergoing hepatectomy. Preoperative determination of remnant liver function may allow assessment of prognosis in patients planned to undergo resection of hepatocellular carcinoma. Preservation of liver functional reserve may be crucial for improved long-term outcomes after hepatectomy in patient with hepatocellular carcinoma.
Generalization of the Local Diabatization Approach for Propagating Electronic Degrees of Freedom in Nonadiabatic Dynamics
Authors: Shakiba Mohammad , Akimov Alexey V. 
Published: February 2023

Abstract
In this Festschrift contribution in honor of Prof. Maurizio Persico, we present a systematic derivation and comprehensive assessment of several integrators for quantum-classical time-dependent Schrodinger (TD-SE) and Liouville (QCLE) equations. We construct a systematic formalism that naturally accounts for trivial state crossing effects and helps solve related phenomena that often pose significant numerical problems in nonadiabatic molecular dynamics simulations. Our derivations generalize and extend the local diabatization approach pioneered by Prof. Persico and co-workers, leading to several new integrators for TD-SE. Further, we extend this formalism to the QCLE integration. We generalize the symmetric splitting integrator proposed by one of us earlier, and demonstrate how it can be applied to integrate both TD-SE and QCLE. We provide detailed discussion of the algorithms and their implementation in the Libra software, and we present their comprehensive assessment with several well-designed model problems.
Albumin-to-Fibrinogen Ratio is an Independent Prognostic Parameter in De Novo non-M3 acute myeloid leukemia
Authors: Ding Yaqun , Qi Xiangyu , Li Yang , Sun Yanni , Wan Jia , Luo Chengxin , Huang Yarui , Li Qingrong , Wu Guixian , Zhu Xiaoqing , Xu Shuangnian 
Published: February 2023

Abstract
Inflammation and nutrition related proteins participate in the development of acute myeloid leukemia (AML). It has been reported that the albumin-to-fibrinogen ratio (AFR) could serve as a prognostic indicator in patients with malignancy, but the precise relevance of AML is unclear. This study aimed to evaluate the effect of AFR on survival prognosis in patients with AML. We analyzed 227 patients newly diagnosed with non-M3 AML. AFR was calculated as albumin divided by fibrinogen. Based on the cutoff point from X-tile program, patients were divided into AFR-high (38.8%) and AFR-low (61.2%) groups. AFR-low group showed poorer complete remission rate (P < 0.001) and median time to relapse (P = 0.026); while the mortality was higher (P = 0.009) than AFR-high ones. According to the log-rank test, AFR-low group had shorter OS (P < 0.001) and DFS (P = 0.034). Multivariate analysis identified AFR, ELN risk, bone marrow transplant, and hemoglobin as independent prognostic variables associated with OS. A visualized nomogram for predicting OS was performed. The C-index (0.75), calibration plots, and decision curve analyses of new model showed better discrimination, calibration, and net benefits than the ELN risk model. The time-dependent receiver operating characteristic (ROC) curve of 1-, 2-, and 3-year also functioned well (AUC, 0.81, 0.93, 0.90, respectively). Our study provided a comprehensive view of AFR which could be an independent prognostic indicator in AML patients. The prognostic model utilized readily available information from ordinary clinical practice to improve predictive performance, identify risks, and assist in therapeutic decision-making.
Comprehensive analysis of the diagnostic and therapeutic value of the hypoxia- related gene PLAUR in the progression of atherosclerosis
Authors: Dai Chengyi , Lin Yuhang 
Published: February 2023

Abstract
Atherosclerosis (AS) is a major contributor to a variety of negative clinical outcomes, including stroke and myocardial infarction. The progression of the lesion is accompanied by a decrease in oxygen diffusion in the area of the plaque. Our research aims to reveal whether hypoxia-related genes are involved in the occurrence and development of AS, and whether they have potential diagnostic and therapeutic value. Combined with the results of differential expression genes (DEG) analysis, weighted gene co-expression network analysis (WGCNA), and random forest analysis, the key hypoxia-related genes highly related to AS progression were selected. To investigate differences in immune infiltration in lesions and the relationship between hypoxia and immune infiltration, single-sample gene set enrichment analysis (ssGSEA), ESTIMATE, and CIBERSORT analyses were performed. On the basis of TarBase, MirTarBase, and DIANA databases, a competitive endogenous RNA (ceRNA) network was constructed to regulate the expression of key gene. Use the DrugMatrix database to predict targeted drugs, and use AutoDock to verify the binding ability of drugs and proteins. We found that hypoxia was prominent in advanced-stage plaques and that there was a broad correlation between the hypoxia microenvironment and immune infiltration. The PLAUR gene has been identified as an effective diagnostic marker for the progression of AS lesions. PLAUR was positively correlated with HIF1A expression and macrophage infiltration in plaques. We predicted that HCG17-hsa-miR-424-5p-HIF1A is a ceRNA network that regulates PLAUR expression. Finally, alprostadil, valsartan, biotin A, luteolin, and curcumin were predicted as potential drugs to delay lesion progression by antagonizing PLAUR. This research has significant implications for the search for new treatment targets and disease prevention as it advances our understanding of the molecular mechanisms that underpin the role of hypoxia in AS progression.
Mining of alluvial cassiterite and its compositional diversity at the Mayo Darlé area, northern Cameron
Authors: Njiganga Nwamba Maurice , Tebogo Tebogo Kelepile , Ngatcha Ralain Bryan , Suh Cheo Emmanuel , Ilouga Charles Dieudonne Isiodore , Shemang Elisha Mutum , Tantoh Bih Solange , Tata Ernest Tata , Agyingi Christopher M. 
Published: February 2023

Abstract

Cassiterite mineralization occurs in both the rock and the alluvial system in the Mayo-Darlé area of northern Cameroon. This study focuses on the morphology, mineral inclusions, and composition of alluvial cassiterite derived from Bambol and Mayo Seni localities, where active alluvial mining by artisans constitutes the most important rural economic activity. The cassiterite grains were primarily analyzed by backscattered electron (BSE) images to investigate their morphological characteristics and mineral inclusions. The composition was examined through electron microprobe analysis (EMPA). The cassiterite grains have an irregular to sub-rounded morphology, indicating proximity to the source, although most of the cassiterite grains display evidence of mechanical transport and abrasion. EMPA results show mainly high SnO2content (93–103 wt. %), highlighting the predominance of cassiterite minerals in the humid tropical region. Among the Sn substituting elements, only Fe, Ta, and Mn were detected at very low concentrations (Fe = 0.02 to 0.3 FeO, Mn = 0 to 0.04 MnO, and Ta = 0 to 0.2 Ta2O5) all in wt. % respectively, suggesting little variation in the alluvial cassiterite compositions. This high SnO2content indicates the purity of cassiterite in the area. Binary plots of compositional variation have similar trends, suggesting that cassiterite was derived from a single bedrock source, despite having a mixed signature of pegmatite- and hydrothermal-derived cassiterite. Mineral inclusions include quartz, hematite, and columbite group minerals (CGMs), which were similar in all the samples, suggesting a homogeneous source. The quartz inclusions highlight quartz veins associated with the mineralization and potential felsic plutonic bedrocks. The chemical signatures of the studied cassiterite grains are useful tools to explore the environment of an unknown primary source that can greatly help in mineral exploration in northern Cameroon.
Metabonomics Application on Screening Serum Biomarkers of Golden
Hamsters with Nonalcoholic Steatohepatitis Induced by High-Fat Diet
Authors: Hu Jingjing , Shen Yueliang , Chen Yunwen 
Published: February 2023

Background:
Nonalcoholic steatohepatitis (NASH) is a common liver injury which will
develop into advanced fibrosis and cirrhosis. This study was designed to identify the different serum
metabolites of NASH hamsters and predict the diagnosis biomarkers for NASH.

Methods:
Golden hamsters were randomly divided into a control group that received a normal diet
and a NASH group that received a high-fat diet (HFD). After 12 weeks of feeding, the body and
liver weight of the hamsters were monitored. Serum biochemical parameters and liver histopathological
changes were analyzed. Moreover, an untargeted metabolomics analysis based on a GCTOF/
MS system was performed to identify the serum differential metabolites between the NASH
and control groups.

Results:
The liver weight was increased in the NASH group, accompanied by significantly higher
levels of serum TC, TG, ALT, AST, LDL-C, and lower HDL-C. HE, Masson, and oil red O staining
showed the hepatocyte structure destroyed, lipid droplets accumulated, and fibers proliferated
in the NASH group. Furthermore, 63 differential metabolites were identified by metabolomic analysis.
Lipids and fatty acids were significantly up-regulated in the NASH group. The top 9 differential
metabolites included cholesterol, methyl phosphate, taurine, alpha-tocopherol, aspartic acid,
etc. Metabolites were mainly involved in amino acid metabolism (glycine, cysteine, taurine),
spermine, fatty acid biosynthesis, urea cycle, bile acid metabolism pathways, etc.

Conclusion:
Metabonomics analysis identified 63 differential metabolites in the serum of NASH
hamsters; among them, lipids and fatty acids had a key role and may be used as biomarkers for the
early diagnosis of NASH.
An Effective Approach to Enhance the Dissolution Profile of Curcumin
and Quercetin: Liquisolid Compacts
Authors: Sharma Shaveta , Arora Vimal , Sharma Teenu 
Published: February 2023

Background:
The drugs categorized under BCS class II and IV are poorly water-soluble,
which in turn affects their dissolution and bioavailability. To overcome these limitations, namely, poor
solubility and bioavailability, several approaches have been tried so far, like, co-solvency, size reduction
or micronization, complexation, adsorption on high surface area carriers, etc.

Objective:
The present article aims to explore the utilization of the liquisolid technique to improve the
dissolution profile of curcumin and quercetin, used as a combination in a solid dosage form. It covers the
study of the impact of various carriers employed in liquisolid technology on drug dissolution profiles;
Avicel pH 101, Fujicalin and Neusilin were used as carriers in this study.

Methods:
The solubility of the drugs was evaluated in various non-volatile solvents except water to select
the vehicle having maximum solubility. All formulations were then prepared using curcumin and quercetin
in a ratio of 2:1 (150 mg curcumin : 75 mg Quercetin), comprising a proportion of 40-60% w/w of the
total mass of the formulation and were estimated for post-compression parameters. During the final processing
of the liquisolid compacts, the carrier is to coating material ratio was kept consistent, i.e., 20:1.

Results:
Powder X-ray Diffraction (PXRD) and Fourier Transform Infrared Spectroscopy (FTIR) were
utilized to analyze drug-excipient interaction; these studies stated no evidence of any physical or chemical
interaction between drug(s) and the excipients. The final product was then evaluated for the liquid adsorption
capacity and in vitro release of the drugs as a combination, and it was observed that these two properties
were found to be significantly improved in the liquisolid compacts.

Conclusion:
The outcomes indicated that the combination of Neusilin as the carrier and castor oil as a
non-volatile solvent was the best-performing formulation appropriate for targeting an improved dissolution
profile.
Organocatalyzed Stereoselective Glycosylation: An Overview of the Last
Decade
Authors: López Mildred , de Parrodi Cecilia Anaya , Huelgas Gabriela , Lozada-Ramírez José Daniel 
Published: February 2023

Abstract:
Even though there has been an important evolution in the synthesis of oligosaccharides, the
efficient and stereoselective study of glycosidic bonds through non-toxic, moderate, and inexpensive
techniques is one of the most challenging fields in organic synthesis. Glycosyl reactions play a
fundamental role in biological material and structure-activity relationships, having numerous medicinal
chemistry applications. For this, interesting strategies have evolved over the years to control the
stereoselectivity of glycosidic bonds, including the manipulation of different reaction elements, mainly
promoters or catalysts, but also involving the nature of donors and solvents. This review looks at
glycosylation methodologies in the last decade resulting in the specific formation of alpha or beta
glycosidic bonds.