bluuebunny/crossref_metadata_2025_split huggingface dataset:
Society 5.0 versus Industry 5.0: An examination of industrialization models in driving sustainable development from a normative stakeholder theory perspective
Authors: Zhang Yindan , Li Yuanyuan 
Published: June 2023

AbstractThe research on Society 5.0 (s5.0) and Industry 5.0 (i5.0) is a relatively new and emerging domain where researchers are still striving to explore the influence within distinct contexts, worldwide. The study investigates the impact of two major models of industrialization, that is, s5.0 and i5.0 to understand the insights into how it triggers the firms' sustainable development by showing empirical examinations from the Chinese industrial sector drawing on normative stakeholder theory perspective. The results asserted that the i5.0 model positively affects sustainable performance (SSP). The empirical analysis confirmed a positive association of s5.0 model toward SSP. In addition, it found that s5.0 and i5.0 models have a positive correlation with the economic perspective of SSP. Second, the findings asserted the positive linkage between i5.0 and s5.0 from a social perspective. Finally, the study found a significant correlation between i5.0 and s5.0 on the environmental factors, respectively. This study equipped both frameworks to empirically conduct the contextual examination showing insights into the embodiment of such capabilities that may support achieving SSP. This study shows insights into certain policy implications. For instance, i5.0 and s5.0 both models support shaping innovative ecosystems, encouraging ethical and sustainable practices, encouraging effective infrastructure, empowering citizen participation, and supporting work for the betterment of society. Finally, the study enlists certain managerial and theoretical recommendations for the industries together with possibilities of future research for scholars of the world.
Causal inference for recurrent events via aggregated marginal odds ratio
Authors: Zhang Wenling , Cotton Cecilia A. 
Published: June 2023

SummaryResearchers often work with treatments and outcomes that vary over time. For example, psychologists are interested in the curative effect of cognitive behavior therapies on patients' recurrent depression symptoms. While there are various causal effect measures designed for one‐time treatment, the causal effect measures for time‐varying treatment and recurrent events are relatively under‐developed. In this article, a new causal measure is proposed to quantify the causal effect of time‐varying treatments on recurrent events. We suggest estimators with robust standard errors that are based on various weight models for both conventional causal measures and the proposed measure in different time settings. We outline the approaches and describe how using some stabilized inverse probability weight models are more advantageous than others. We demonstrate that the proposed causal estimand can be consistently estimated for study periods of moderate length, and the estimation results are compared under different treatment settings with various weight models. We also find that the proposed method is suitable for both absorbing and nonabsorbing treatments. The methods are applied to the 1997 National Longitudinal Study of Youth as an illustrative example.
Pyrazolo[5,1‐b]quinazolines and Their Bis‐analogues Linked to Different Spacers: Regioselective Synthesis, Antibacterial Screening and SwissADME Prediction Study
Authors: Sanad Sherif M. H. , Mekky Ahmed E. M. , Ahmed Ahmed A M. 
Published: June 2023

AbstractThe regioselective synthesis of a new series of pyrazolo[5,1‐b]quinazolines was carried out using a three‐component protocol. The protocol involved the reaction of the appropriate benzaldehydes, dimedone, and 1H‐pyrazole‐ 3,5‐diamine in DMF at 150 °C. Using a similar protocol, three additional series of bis(pyrazolo[5,1‐b]quinazolines), linked to different spacers, were prepared utilizing the respective bis(aldehydes). The new products showed a wide spectrum of antibacterial activity against six different the American Type Culture Collection (ATCC) bacterial strains. In general, p‐xylene‐linked bis(pyrazolo[5,1‐b]quinazolines) had good antibacterial activity with minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) values up to 8.3 and 16.6 μM, respectively. Additionally, (4‐nitrophenyl)‐linked pyrazolo[5,1‐b]quinazoline had the best antibacterial activity with MIC/MBC values up to 2.1/4.3 μM. The Salmonella typhimurium reverse mutation assay (Ames mutagenicity test) was used to conclude that the (4‐nitrophenyl)‐linked product was not mutagenic to the Salmonella strains. Both the drug‐likeness model score and the SwissADME predict the (4‐nitrophenyl)‐linked product‘s good physicochemical properties, and drug likeness.
Influence of Acid Catalyst on the Synthesis of trans‐Porphyrins and Crystal Structure of a 5‐(Pyren‐1‐yl)dipyrromethane
Authors: Sundharamurthi Subramani , Bhyrappa Puttaiah 
Published: June 2023

AbstractA family of trans‐porphyrins (A2B2, A2BC and A2C2), including fewer fused cyclic aromatics, was synthesized using 5‐mesityldipyrromethane under negligible scrambling reaction conditions in high yields (15–48 %) with BF3(OEt2)/EtOH relative to that in trifluoroacetic acid (12–22 %) in CHCl3. The push‐pull trans‐A2BC, Zn(II)‐carboxy porphyrins were prepared from their ester porphyrins and examined their fluorescence and electrochemical redox properties. In addition, the synthesis and single‐crystal X‐ray structure of a 5‐(pyren‐1‐yl)dipyrromethane are also reported.
Unveiling the N‐Nucleophilicity of Non‐Aromatic Pyrroles Through Rhodium Catalysis: A Case of Synthesis and Luminescence Studies of Pyrrolo[2,1‐a]isoquinolinium Salts
Authors: Shabalin Dmitrii A. , Zelenkov Lev E. 
Published: June 2023

AbstractAn expedient synthesis of hitherto unknown pyrrolo[2,1‐a]isoquinolinium salts from non‐aromatic aryl‐substituted 2H‐ and 3H‐pyrroles and internal alkynes has been developed. The process represents a rare example of N‐nucleophilic reaction of 2H‐ and 3H‐pyrroles and relies on theortho‐C−H bond activation of non‐aromatic arylpyrroles in the presence of rhodium catalyst followed by alkyne annulation reaction. A broad range of diversely substituted salts was obtained in high yields under mild reaction conditions. The photophysical properties for selected representatives of novel pyrrolo[2,1‐a]isoquinolinium salts have been evaluated to demonstrate their potential as fluorescent materials for light‐emitting devices and bioimaging.
Standardization Approaches for Extracellular Vesicle Loading with Oligonucleotides and Biologics
Authors: Roerig Josepha , Schulz‐Siegmund Michaela 
Published: June 2023

AbstractExtracellular vesicles (EVs) are widely recognized for their potential as drug delivery systems. EVs are membranous nanoparticles shed from cells. Among their natural features are their ability to shield cargo molecules against degradation and enable their functional internalization into target cells. Especially biological or bio‐inspired large molecules (LMs), like nucleic acids, proteins, peptides, and others, may profit from encapsulation in EVs for drug delivery purposes. In the last years, a variety of loading protocols are explored for different LMs. The lack of standardization in the EV drug delivery field has impeded their comparability so far. Currently, the first reporting frameworks and workflows for EV drug loading are proposed. The aim of this review is to summarize these evolving standardization approaches and set recently developed methods into context. This will allow for enhanced comparability of future work on EV drug loading with LMs.
Construction of Microfluidic Chip Structure for Cell Migration Studies in Bioactive Ceramics
Authors: Ye Sheng , Cao Quanle , Ni Panxianzhi , Xiong Shuting , Zhong Meng , Yuan Tun , Shan Jing , Liang Jie , Fan Yujiang , Zhang Xingdong 
Published: June 2023

AbstractCell migration is an essential bioactive ceramics property and critical for bone induction, clinical application, and mechanism research. Standardized cell migration detection methods have many limitations, including a lack of dynamic fluid circulation and the inability to simulate cell behavior in vivo. Microfluidic chip technology, which mimics the human microenvironment and provides controlled dynamic fluid cycling, has the potential to solve these questions and generate reliable models of cell migration in vitro. In this study, a microfluidic chip is reconstructed to integrate the bioactive ceramic into the microfluidic chip structure to constitute a ceramic microbridge microfluidic chip system. Migration differences in the chip system are measured. By combining conventional detection methods with new biotechnology to analyze the causes of cell migration differences, it is found that the concentration gradients of ions and proteins adsorbed on the microbridge materials are directly related to the occurrence of cell migration behavior, which is consistent with previous reports and demonstrates the effectiveness of the microfluidic chip model. This model provides in vivo environment simulation and controllability of input and output conditions superior to standardized cell migration detection methods. The microfluidic chip system provides a new approach to studying and evaluating bioactive ceramics.
Positive Charge Holes Revealed by Energy Band Theory in Multiphase TixO2x‐1 and Exploration of its Microscopic Electromagnetic Loss Mechanism
Authors: Li Yang , Qing Yuchang , Cao Yaru , Luo Fa , Wu Hongjing 
Published: June 2023

AbstractAlthough numerous experimental investigations have been carried out on the problem of defect engineering in semiconductor absorbers, the relationship among charge carrier, defects, heterointerfaces, and electromagnetic (EM) wave absorption has not been established systematically. Herein, the new thermodynamic and kinetic control strategy is proposed to establish multiphase TixO2x−1 (1 ≤ x ≤ 6) through a hydrogenation calcination. The TiOC‐900 composite shows the efficient EM wave absorption capability with a minimum reflection loss (RLmin) of −69.6 dB at a thickness of 2.04 mm corresponding to an effective absorption bandwidth (EAB) of 4.0 GHz due to the holes induced conductance loss and heterointerfaces induced interfacial polarization. Benefiting from the controllable preparation of multiphase TixO2x−1, a new pathway is proposed for designing high‐efficiency EM wave absorbing semiconducting oxides. The validity of the method for adopting energy band theory to explore the underlying relations among charge carriers, defects, heterointerfaces, and EM properties in multiphase TixO2x−1 is demonstrated for the first time, which is of great importance in optimizing the EM wave absorption performance by electronic structure tailoring.
Violet Antimony Phosphorus with Enhanced Photocatalytic Hydrogen Evolution
Authors: Zhao Xuewen , Gu Mengyue , Zhai Rui , Zhang Yuhao , Jin Mengting , Wang Yanhao , Li Jiangfan , Cheng Yonghong , Xiao Bing , Zhang Jinying 
Published: June 2023

AbstractViolet phosphorus (VP), a recently confirmed layered elemental structure, is demonstrated to have unique photoelectric, mechanical, and photocatalytic properties. Element substitution plays a significant role in modifying the physical/chemical properties of semiconducting materials. Herein, antimony is adopted to substitute some phosphorus atoms in VP crystals to tune their physical and chemical properties, resulting in a significantly enhanced photocatalytic hydrogen evolution performance. The antimony‐substituted violet phosphorus single crystal (VP‐Sb) is synthesized and characterized by single crystal X‐ray diffraction (CSD‐2214937). The bandgap of VP‐Sb has been found to be lowered from that of VP by UV/vis diffuse reflectance spectroscopy and density‐functional theory (DFT) calculation, enhancing the optical absorption during photocatalytic reaction. The conducting band minimum of VP‐Sb is found to be upshifted from that of VP from measurements and calculation, enhancing its hydrogen reduction activity. The valance band maximum is found to be lowered to weaken its oxidation activity. The edge of VP‐Sb is calculated to have an excellent H* adsorption–desorption performance and superior H2 generation kinetics. The H2 evolution rate of VP‐Sb is demonstrated to be significantly enhanced to be 1473 µmol h−1 g−1, about five times of that of pristine VP (299 µmol h−1 g−1) under the same experimental conditions.
A call to address structural barriers to Hispanic/Latino representation in clinical trials on Alzheimer's disease and related dementias: A micro‐meso‐macro perspective
Authors: Aranda María P. , Marquez David X. , Gallagher‐Thompson Dolores , Pérez Adriana , Rojas Julio C. , Hill Carl V. , Reyes Yarissa , Dilworth‐Anderson Peggye , Portacolone Elena 
Published: June 2023

AbstractIntroductionThis perspective paper addresses the US Hispanic/Latino (herein, Latino) experience with regards to a significant public health concern—the underrepresentation of Latino persons in Alzheimer's disease and related dementias (AD/ADRD) clinical trials. Latino individuals are at increased risk for AD/ADRD, experience higher disease burden, and low receipt of care and services. We present a novel theoretical framework—the Micro‐Meso‐Macro Framework for Diversifying AD/ADRD Trial Recruitment—which considers multi‐level barriers and their impact on Latino trial recruitment.MethodsBased on a review of the peer‐reviewed literature and our lived experience with the Latino community, we drew from our interdisciplinary expertise in health equity and disparities research, Latino studies, social work, nursing, political economy, medicine, public health, and clinical AD/ADRD trials. We discuss factors likely to impede or accelerate Latino representation, and end with a call for action and recommendations for a bold path forward.ResultsIn the 200+ clinical trials conducted with over 70,000 US Americans, Latino participants comprise a fraction of AD/ADRD trial samples. Efforts to recruit Latino participants typically address individual‐ and family‐level factors (micro‐level) such as language, cultural beliefs, knowledge of aging and memory loss, limited awareness of research, and logistical considerations. Scientific efforts to understand recruitment barriers largely remain at this level, resulting in diminished attention to upstream institutional‐ and policy‐level barriers, where decisions around scientific policies and funding allocations are ultimately made. These structural barriers are comprised of inadequacies or misalignments in trial budgets, study protocols, workforce competencies, healthcare‐related barriers, criteria for reviewing and approving clinical trial funding, criteria for disseminating findings, etiological focus and social determinants of health, among others.ConclusionFuture scientific work should apply and test the Micro‐Meso‐Macro Framework for Diversifying AD/ADRD Trial Recruitment to examine structural recruitment barriers for historically underrepresented groups in AD/ADRD research and care.
Comparison of the prognostic validity of three simplified consciousness assessment scales with the Glasgow Coma Scale
Authors: Anestis Dimitrios M. , Marinos Konstantinos , Tsitsopoulos Parmenion P. 
Published: June 2023

Abstract
Background
Various tools simpler than the Glasgow Coma Scale (GCS) have been proposed for the assessment of consciousness. In this study, the validity of three coma scales [Simplified Motor Scale, Modified GCS Motor Response, and AVPU (alert, verbal, painful, unresponsive)] is evaluated for the recognition of coma and the prediction of short- and long-term mortality and poor outcome. The predictive validity of these scales is also compared to the GCS.

Methods
Patients treated in the Department of Neurosurgery and the Intensive Care Unit in need of consciousness monitoring were assessed by four raters (two consultants, a resident and a nurse) using the GCS. The corresponding values of the simplified scales were estimated. Outcome was recorded at discharge and at 6 months. Areas Under the Receiver Operating Characteristic Curve (AUCs) were calculated for the prediction of mortality and poor outcome, and the identification of coma.

Results
Eighty-six patients were included. The simplified scales showed good overall validity (AUCs > 0.720 for all outcomes of interest), but lower than the GCS. For the identification of coma and the prediction of long-term poor outcome, the difference was significant (p < 0.050) for all the ratings of the most experienced rater. The validity of these scales was comparable to the GCS only in predicting in-hospital mortality, but without this being consistent for all raters.

Conclusion
The simplified scales showed inferior validity than the GCS. Their potential role in clinical practice needs further investigation. Thus, the replacement of the GCS as the main scale for consciousness assessment cannot be currently supported.
Risikofaktoren für postoperative Hypoxämie während des Transportes in den Aufwachraum und Einfluss von Transport-Monitoring
Authors: Haller Katharina , Trauzeddel Ralf Felix , Treskatsch Sascha , Berger Christian 
Published: June 2023

Zusammenfassung
Hintergrund
Auf Transportwegen innerhalb eines Zentral-OP nach der Narkoseausleitung in den Aufwachraum (AWR) sind Patienten hypoxämiegefährdet. Spezifische Risikofaktoren sind jedoch nicht abschließend geklärt, und einheitliche Empfehlungen zur Überwachung der Vitalparameter bei Transporten innerhalb eines OP-Komplexes existieren nicht. Ziel dieser retrospektiven Datenbankanalyse war es, Risikofaktoren für eine Hypoxämie auf diesen Transporten zu identifizieren und zu prüfen, ob die Verwendung eines Transport-Monitorings (TM) den initialen Wert der peripher-venösen Sauerstoffsättigung (SpO2) im AWR beeinflusst.

Material und Methoden
An einem retrospektiv extrahierten Datensatz von Eingriffen in Allgemeinanästhesie innerhalb eines Zentral-OP einer Universitätsklinik von 2015 bis 2020 wurden Risikofaktoren für eine initiale Hypoxämie im AWR (SpO2 < 90 %) mittels multivariater Analyse ermittelt. Nach Aufteilung des Datensatzes in Patienten ohne TM (Gruppe OM) und mit TM (Gruppe MM) und Propensity Score Matching wurde der Einfluss des TM untersucht.

Ergebnisse und Diskussion
Acht Risikofaktoren für eine initiale Hypoxämie im AWR konnten identifiziert werden: Alter > 65 Jahre, body mass index (BMI) > 30 kg/m2, chronisch obstruktive Lungenerkrankung (COPD), intraoperativer Beatmungsdruck-Hub (∆p) > 15 mbar und positiver endexpiratorischer Druck (PEEP) > 5 mbar, intraoperative Gabe eines lang wirksamen Opioids, erste präoperative SpO2 < 97 % sowie nach Anästhesieausleitung letzte im OP gemessene SpO2 < 97 %. Bei 90 % aller Patienten lag mindestens ein Risikofaktor für eine postoperative Hypoxämie vor. Bei Vorliegen von Risikofaktoren geht die Verwendung eines TM mit einer geringeren initialen Desaturierung (MM: 97 [94; 99] %, OM: 96 [94; 98] %, p < 0,001) im AWR einher. Demnach erscheint eine konsequente Nutzung von TM auch auf kurzen Transporten innerhalb eines zusammenhängenden OP-Komplexes sinnvoll.
Features and outcomes of bailout repeat transcatheter aortic valve implantation (TAVI): the Bailout Acute TAVI-in-TAVI to Lessen Events (BATTLE) international registry
Authors: Giordano Arturo , Corcione Nicola , Barbanti Marco , Costa Giuliano , Dipietro Elena , Amat-Santos Ignacio J. , Gómez-Herrero Javier , Latib Azeem , Scotti Andrea , Testa Luca , Bedogni Francesco , Schaefer Andreas , Russo Marco , Musumeci Francesco , Ferraro Paolo , Morello Alberto , Cimmino Michele , Albanese Michele , Pepe Martino , Giordano Salvatore , Biondi-Zoccai Giuseppe 
Published: June 2023

Abstract
Aim
Transcatheter aortic valve implantation (TAVI) is a mainstay in the management of severe aortic stenosis in patients with intermediate to prohibitive surgical risk. When a single TAVI device fails and cannot be retrieved, TAVI-in-TAVI must be performed acutely, but outcomes of bailout TAVI-in-TAVI have been incompletely appraised. We aimed at analyzing patient, procedural and outcome features of patients undergoing bailout TAVI-in-TAVI in a multicenter registry.

Methods
Details of patients undergoing bailout TAVI-in-TAVI, performed acutely or within 24 h of index TAVI, in 6 international high-volume institutions, were collected. For every case provided, 2 same-week consecutive controls (prior TAVI, and subsequent TAVI) were provided. Outcomes of interest were procedural and long-term events, including death, myocardial infarction, stroke, access site complication, major bleeding, and reintervention, and their composite (i.e. major adverse events [MAE]).

Results
A total of 106 patients undergoing bailout TAVI-in-TAVI were included, as well as 212 controls, for a total of 318 individuals. Bailout TAVI-in-TAVI was less common in younger patients, those with higher body mass index, or treated with Portico/Navitor or Sapien devices (all p < 0.05). Bailout TAVI-in-TAVI was associated with higher in-hospital rates of death, emergency surgery, MAE, and permanent pacemaker implantation (all p < 0.05). Long-term follow-up showed that bailout TAVI-in-TAVI was associated with higher rates of death and MAE (both < 0.05). Similar findings were obtained at adjusted analyses (all p < 0.05). However, censoring early events, outlook was not significantly different when comparing the two groups (p = 0.897 for death, and p = 0.645 for MAE).

Conclusions
Bail-out TAVI-in-TAVI is associated with significant early and long-term mortality and morbidity. Thus, meticulous preprocedural planning and sophisticated intraprocedural techniques are of paramount importance to avoid these emergency procedures.
Automated inversion time selection for black-blood late gadolinium enhancement cardiac imaging in clinical practice
Authors: Maillot Aurélien , Sridi Soumaya , Pineau Xavier , André-Billeau Amandine , Hosteins Stéphanie , Maes Jean-David , Montier Géraldine , Nuñez-Garcia Marta , Quesson Bruno , Sermesant Maxime , Cochet Hubert , Stuber Matthias , Bustin Aurélien 
Published: June 2023

Abstract
Objective
To simplify black-blood late gadolinium enhancement (BL-LGE) cardiac imaging in clinical practice using an image-based algorithm for automated inversion time (TI) selection.

Materials and methods
The algorithm selects from BL-LGE TI scout images, the TI corresponding to the image with the highest number of sub-threshold pixels within a region of interest (ROI) encompassing the blood-pool and myocardium. The threshold value corresponds to the most recurrent pixel intensity of all scout images within the ROI. ROI dimensions were optimized in 40 patients’ scans. The algorithm was validated retrospectively (80 patients) versus two experts and tested prospectively (5 patients) on a 1.5 T clinical scanner.

Results
Automated TI selection took ~ 40 ms per dataset (manual: ~ 17 s). Fleiss’ kappa coefficient for automated-manual, intra-observer and inter-observer agreements were $$\overline{\kappa }$$

κ
¯

= 0.73, $$\overline{\kappa }$$

κ
¯

= 0.70 and $$\overline{\kappa }$$

κ
¯

= 0.63, respectively. The agreement between the algorithm and any expert was better than the agreement between the two experts or between two selections of one expert.

Discussion
Thanks to its good performance and simplicity of implementation, the proposed algorithm is a good candidate for automated BL-LGE imaging in clinical practice.