bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk of a second cancer and infection in patients with indolent B‐cell lymphoma exposed to first‐line bendamustine plus rituximab: A retrospective analysis of an administrative claims database
Authors: Dote Satoshi , Inose Ryo , Goto Ryota , Kobayashi Yuka , Muraki Yuichi 
Published: February 2023

AbstractBendamustine has a potent immunosuppressive effect because it causes T‐cell lymphopenia, which might lead to a second primary malignancy (SPM) and would increase the risk of infection. Using the Medical Data Vision administrative claims database, we compared the cumulative incidence of SPM, infections within 6 months, and overall survival (OS) among untreated patients with indolent B‐cell lymphomas (iBCL) who received rituximab‐based chemotherapy between 2009 and 2020. Patients with grade 3b follicular lymphoma or a previous history of malignancy were excluded. Eligible 5234 patients were assigned to three cohorts: rituximab monotherapy (N = 780), RCHOP/RCVP/RTHPCOP (doxorubicin replaced with pirarubicin) (N = 2298), or bendamustine/rituximab (BR) (N = 2156). There were 589 recorded SPMs, of which myelodysplastic syndromes were the most common (1.7%). The cumulative incidence of SPM was significantly higher in patients treated with BR than in those treated with rituximab monotherapy (p < 0.01) or RCHOP/RCVP/RTHPCOP (p < 0.0001): the 5‐year cumulative incidence function was 18.1%, 12.5%, and 12.9%, respectively. In the Fine‐Gray subdistribution hazards model, BR showed a significantly higher cumulative incidence of SPM than RCHOP/RCVP/RTHPCOP (subhazard ratio, 1.33; 95% confidence interval [CI], 1.10–1.61). Furthermore, in sensitivity analysis, a nested case‐control study using an entire cohort showed consistent results: the SPM odds ratios (95% CI) of first‐line bendamustine, bendamustine after first‐line, and any‐line bendamustine were 1.43 (1.14–1.78), 1.26 (0.96–1.64), and 1.33 (1.09–1.62), respectively. Regarding infections, adjusted odds ratios (95% CI) of BR compared to RCHOP/RCVP/RTHPCOP were as follows: cytomegalovirus infection, 13.7 (4.88–38.4); bacterial pneumonia, 0.63 (0.50–0.78); and pneumocystis pneumonia, 0.24 (0.11–0.53). There was no significant difference in OS between RCHOP/RCVP/RTHPCOP and BR in patients with follicular, mantle cell, marginal zone, or lymphoplasmacytic lymphomas. In conclusion, treatment strategies that consider the risk of SPM and infections after chemotherapy are warranted in patients with iBCL.
Evaluation of the quality of clinical guidelines for prophylaxis of venous thromboembolism in urological surgeries by the AGREE II review instrument
Authors: Shakiba Behnam , Kabir Ali , Irani Shirin , Torabi Nasim , Nourmohamad Vahid , Farid Mohaddese 
Published: February 2023

AbstractBackground and AimsVenous thromboembolism (VTE) is the most common cause of death during the first 30 days after surgery. There is not any study which critically evaluated clinical guidelines related to VTE prophylaxis in urological surgeries. Therefore, in this study, we decided to evaluate related clinical guidelines using the AGREE II instrument to take a positive step towards improving the care of these patients.MethodsThe latest version of all available clinical guidelines related to the topic of VTE prophylaxis in urological surgeries until 2021 was searched. Four appraisers, including one urologist, one cardiologist, one epidemiologist, and one MD who had prior knowledge of working with the AGREE II tool and international articles in this field appraised selected clinical guidelines. Using the AGREE II review tool, clinical guidelines were critically evaluated. Then, the score of six domains of AGREE II for each guideline was calculated and compared with each other, and the relationship between the domains was measured by Kendall's correlation test. To determine the reliability of the test, interclass correlation coefficients were calculated for all indicators.ResultsItems were rated on a 7‐point scale from 1 (strongly disagree) to 7 (strongly agree). NICE, CHEST, and EAU guidelines obtained the highest scores from the Overall Assessment criteria by scoring 6, 5.75, and 5.25, respectively. There was only a correlation between the score of Overall Assessment criterion with “Applicability” domain, with Kendall's correlation coefficient of 0.867 and p = 0.015. The domains of “Clarity and presentation” and “Scope and purpose” obtained the highest standardized scores by getting 84.49% and 75.69%, respectively, and “Applicability” with 30.04% obtained the lowest standardized score.ConclusionIn this study, NICE, CHEST, and EAU guidelines are suggested as clinical guidelines by obtaining the highest scores from Overall Assessment criterion.
Comparative study of clinical symptoms of chronic rhinosinusitis with nasal polyps patients
Authors: Hu Jingmin , Wang Le , Ma Ruixia 
Published: February 2023

AbstractAimThe aim of this study is to explore the clinical characteristics in chronic rhinosinusitis with nasal polyps (CRSwNP) patients with different serum specific IgE (SIgE) and eosinophilic granulocyte infiltration status.MethodsThis retrospective observational study included patients diagnosed with CRSwNP and underwent functional endoscopic sinus surgery at the Yinchuan First People's Hospital between June 2019 and June 2021. A total of 192 patients with CRSwNP were included (100 males). The patients were 41.7 ± 15.1 years old. The disease course ranged 4.6–18.2 months. The visual analog scale (VAS) score (p < .001), endoscopic score (p = .014), computerized tomography (CT) score (p < .00) and the sino‐nasal outcome Test‐22 (SNOT‐22) score (p < .001) were significantly different among patients with SIgE‐positive combined eosinophilic chronic rhinosinusitis (ECRS), patients with SIgE‐positive combined non‐ECRS, patients with SIgE‐negative combined ECRS, and patients with SIgE‐negative combined non‐ECRS.ResultsIn pairwise comparison, the VAS score (20.72 ± 2.24 vs. 13.09 ± 1.62, 13.84 ± 1.34, and 12.67 ± 1.20, respectively), endoscopic score (8.09 ± 1.04 vs. 7.06 ± 0.98, 7.69 ± 1.18, and 7.75 ± 1.07, respectively), CT score (13.18 ± 1.66 vs. 8.79 ± 0.88, 11.08 ± 1.12, and 11.08 ± 1.12, respectively), and SNOT‐22 score (27.62 ± 2.31 vs. 12.09 ± 1.83, 14.84 ± 1.84, and 12.97 ± 1.50, respectively) was significantly higher in patients with SIgE‐positive combined ECRS compared to patients with SIgE‐positive combined non‐ECRS, patients with SIgE‐positive combined non‐ECRS (all p < .0083). The VAS score, endoscopic score, and CT score might be higher in CRSwNP patients with SIgE‐positive combined ECRS.ConclusionIn this study, the VAS score, endoscopic score, and CT score were higher in the patients with SIgE‐positive combined ECRS. This study might provide a reference for treatment in patients with CRSwNP.
Viral load of SARS‐CoV‐2 Omicron BA.5 is lower than that of BA.2 despite the higher infectivity of BA.5
Authors: Takatsuki Yuna , Takahashi Yuta , Nakajima Jun , Iwasaki Yumi , Nagano Katsutoshi , Tani‐Sassa Chihiro , Yuasa Sonoka , Kanehira Saki , Sonobe Kazunari , Nukui Yoko , Takeuchi Hiroaki , Tanimoto Kousuke , Tanaka Yukie , Kimura Akinori , Ichimura Naoya , Tohda Shuji 
Published: February 2023

AbstractBackgroundSublineage BA.5 of the SARS‐CoV‐2 Omicron variant rapidly spread and replaced BA.2 in July 2022 in Tokyo. A high viral load can be a possible cause of high transmissibility.Methods and ResultsThe copy numbers of SARS‐CoV‐2 in nasopharyngeal swab samples obtained from all patients visiting the hospital where this research was conducted were measured using reverse transcription‐quantitative polymerase chain reaction (RT‐qPCR). Viral genotypes were determined using PCR‐based melting curve analysis. Next, whole‐genome sequencing was performed using approximately one fifth of the samples to verify the viral genotypes determined using PCR. Then, the copy numbers of the BA.1, BA.2, and BA.5 cases were compared. Contrary to expectations, the copy numbers of the BA.5 cases (median 4.7 × 104 copies/μL, n = 291) were significantly (p = .001) lower than those of BA.2 cases (median 1.1 × 105 copies/μL, n = 184). There was no significant difference (p = .44) between the BA.5 and BA.1 cases (median, 3.3 × 104 copies/μL; n = 215). Conclusion: The results presented here suggest that the increased infectivity of BA.5 is not caused by higher viral loads, but presumably by other factors such as increased affinity to human cell receptors or immune escape due to its L452R mutation.
Melatonin reduces IL‐33 and TSLP expression in human nasal epithelial cells by scavenging ROS directly
Authors: Gong Min‐jie , Zhang Hai‐bao , Lou Miao , Wang Yu‐sheng , Ma Rui‐ping , Hu Zhen‐zhen , Zheng Guo‐xi , Zhang Ya 
Published: February 2023

AbstractBackgroundChronic rhinosinusitis (CRS) is a chronic mucosal inflammation of the nasal cavity and sinuses. It is classified into CRS without nasal polyps and CRS with nasal polyps (CRSwNP). CRSwNP has high recurrence, especially CRSwNP with massive eosinophil infiltration which is mediated by type 2 inflammatory response. Melatonin is a hormone secreted by the pineal gland, it has powerful antioxidant and anti‐inflammatory effects in addition to regulating biological rhythms. There are no studies on melatonin for the treatment of CRS, so we aimed to explore whether melatonin could be used for the treatment of CRS.Materials and MethodsIn this study, we used melatonin to treat a cell model of CRS. Subsequently, MTT assay was performed to examine the cell viability of human nasal epithelial cells (HNEpCs), a reactive oxygen species (ROS) kit to detect ROS production, a malondialdehyde (MDA) kit to detect the MDA content in the cell culture supernatant, and an apoptosis kit and Western blot analysis to detect apoptosis. The expressions of Nrf2, HO‐1, IL‐33, TSLP, and IL‐25 were detected by Western blot analysis.ResultsMelatonin improved the viability of HNEpCs, reduced lipopolysaccharide‐induced ROS, reduced the MDA content, and inhibited their apoptosis. More importantly, melatonin reduced the expression of IL‐33 and TSLP, an important phenomenon for the treatment of CRSwNP.ConclusionMelatonin protects HNEpCs from damage in inflammation and reduces IL‐33 and TSLP expression of HNEpCs.
Lived experiences of utilizing cultural resiliency to navigate traumatic loss
Authors: Tyler Jessica Meléndez , Darrow Nancy E. Thacker , Outlaw Aisha B. , Guffin Jennifer P. 
Published: February 2023

AbstractExtensive literature focuses on grief and loss and individual levels of resiliency, while less research has been done on cultural resiliency. This phenomenological study examined the lived experiences of using cultural resiliency to cope with traumatic loss in 2020. Compounded grief experiences and effects, emotional impacts, learned resiliency, cultural protective factors, and therapy experiences emerged as themes from these narratives. Implications for the field are provided to expand our thinking about ways to decolonize counseling.
Helicobacter pylori‐derived outer membrane vesicles contribute to Alzheimer's disease pathogenesis via C3‐C3aR signalling
Authors: Xie Junhua , Cools Lien , Van Imschoot Griet , Van Wonterghem Elien , Pauwels Marie J. , Vlaeminck Ine , De Witte Chloë , EL Andaloussi Samir , Wierda Keimpe , De Groef Lies , Haesebrouck Freddy , Van Hoecke Lien , Vandenbroucke Roosmarijn E. 
Published: February 2023

AbstractThe gut microbiota represents a diverse and dynamic population of microorganisms that can influence the health of the host. Increasing evidence supports the role of the gut microbiota as a key player in the pathogenesis of neurodegenerative diseases, including Alzheimer's disease (AD). Unfortunately, the mechanisms behind the interplay between gut pathogens and AD are still elusive. It is known that bacteria‐derived outer membrane vesicles (OMVs) act as natural carriers of virulence factors that are central players in the pathogenesis of the bacteria. Helicobacter pylori (H. pylori) is a common gastric pathogen and H. pylori infection has been associated with an increased risk to develop AD. Here, we are the first to shed light on the role of OMVs derived from H. pylori on the brain in healthy conditions and on disease pathology in the case of AD. Our results reveal that H. pylori OMVs can cross the biological barriers, eventually reaching the brain. Once in the brain, these OMVs are taken up by astrocytes, which induce activation of glial cells and neuronal dysfunction, ultimately leading to exacerbated amyloid‐β pathology and cognitive decline. Mechanistically, we identified a critical role for the complement component 3 (C3)‐C3a receptor (C3aR) signalling in mediating the interaction between astrocytes, microglia and neurons upon the presence of gut H. pylori OMVs. Taken together, our study reveals that H. pylori has a detrimental effect on brain functionality and accelerates AD development via OMVs and C3‐C3aR signalling.
A cost‐effective DC microgrid system for resilient power supply to grid‐connected societies
Authors: Kumar Jaynendra , Agarwal Anshul , Singh Nitin 
Published: February 2023

AbstractLocal renewable energy sources have the potential to provide power security to societies. The main objective of this research is to improve electricity reliability in grid‐connected societies in case of the grid failure or during blackouts. Here, a cost‐effective method to utilize local irregular renewable energy sources for community applications has been proposed. Solar PV, pumping units, domestic loads, and pico hydro are the main parts of the proposed system. The storage water tank also performs the function of pump storage to deliver power during off‐sun periods. The pump storage generates electricity by using the unused potential of the water stored in the storage tank. In islanded mode, the system delivers power to the village to essential loads and fluctuating power to the dump load. The paper provides a case study in which the proposed DC microgrid has been demonstrated for a society to validate the system's performance for different practical scenarios. It has been validated for financial and technical feasibility through economic analysis and MATLAB Simulation performance respectively.
Strain distribution in the bursal rotator cuff based on whole‐muscle and muscle subregion‐specific loading: A cadaveric study
Authors: Yuri Takuma , Prado Maria , Trevino Jose H. , Giambini Hugo 
Published: February 2023

AbstractRotator cuff (RC) tears are common injuries leading to significant dysfunction of the shoulder. Rotator cuff tears alter tension and strain in muscles and tendons. Anatomical studies demonstrated that rotator cuff muscles are comprised of anatomical subregions. However, the strain distribution within the rotator cuff tendons generated from the tension from each anatomical subregion is unknown. We hypothesized that subregions would present distinct 3‐dimensional (3D) strain distributions within the rotator cuff tendons, and that the anatomical insertion configuration of the supraspinatus (SSP) and infraspinatus (ISP) tendons might dictate strain, thus tension, transmission. 3D‐strains in the bursal side of the SSP and ISP tendons of eight fresh‐frozen cadaveric intact shoulders were obtained by applying tension on the whole SSP and ISP muscles, and on their subregions using an MTS system. Strains in the anterior region of the SSP tendon were higher than in the posterior region with whole‐SSP anterior‐region (p < 0.05) and whole‐SSP muscle loading. Higher strains were observed in the inferior half of the ISP tendon with whole‐ISP muscle (p < 0.05), middle‐subregion (p < 0.01), and superior‐subregion (p < 0.05) loading. Tension generating from the posterior‐region of the SSP was primarily transmitted to the middle facet via an overlap between the SSP and ISP tendons insertions, while the anterior‐region mainly distributed its tension into the superior facet. Tension generating from the middle and superior‐regions of the ISP was distributed into the inferior portion of the ISP tendon. These results emphasize the importance of the distinct anatomical subregions of the SSP and ISP muscles in distributing the tension to the tendons.
Tendon cell and tissue culture: Perspectives and recommendations
Authors: Szczesny Spencer E. , Corr David T. 
Published: February 2023

AbstractThe wide variety of cell and tissue culture systems used to study and engineer tendons can make it difficult to choose the best approach and “optimal” culture conditions to test a given hypothesis. Therefore, a breakout session was organized at the 2022 ORS Tendon Section Meeting that focused on establishing a set of guidelines for conducting cell and tissue culture studies of tendon. This paper summarizes the outcomes of that discussion and presents recommendations for future studies. In the case of studying tendon cell behavior, cell and tissue culture systems are reductionist models in which the culture conditions should be strictly defined to approximate the in vivo condition as closely as possible. In contrast, for tissue engineering tendon replacements, the culture conditions do not need to replicate native tendon, but the outcome measures for success should be narrowly defined for the specific clinical application. Common recommendations for both applications are that researchers should perform a baseline phenotypic characterization of the cells that are ultimately used for experimentation. For models of tendon cell behavior, culture conditions should be well justified by existing literature and meticulously reported, tissue explant viability should be assessed, and comparisons to in vivo conditions should be made to determine baseline physiological relevance. For tissue engineering applications, the functional/structural/compositional outcome targets should be defined by the specific tendons they seek to replace, with key biologic and material properties prioritized for construct assessment. Lastly, when engineering tendon replacements, researchers should utilize clinically approved cGMP materials to facilitate clinical translation.
A seat for all: Advancing racial equity in scholarly publishing of health policy and health services research
Authors: Watts Vabren L. , Sweet Patti , Odai‐Afotey Patrick , Ashby‐Rosellon Arronoel , Dey Annesa 
Published: February 2023

Key points
Racial bias, either unconcious or concious, can be present in practices and procedures within scholarly publishing.
To address racial biases, enterprises within scholarly publishing can create a thoughtful and sustainable strategy to course correct racial bias.
Advancing and sustaining aspects of equity or health equity requires time and financial allocations. Hiring a staff member(s) to lead and implement strategy is imperative. It is also important to curate an adivsory council of non‐staff experts in equity to help guide strategy.
Make the journal's equity goals public for social accountability.
Be open to modifying or appending equity strategy. As strategies are implemented other inequities might be exposed.
“Out‐of‐the‐box” Granular Gel Bath Based on Cationic Polyvinyl Alcohol Microgels for Embedded Extrusion Printing
Authors: Zeng Jinfeng , Xie Zhengtian , Dekishima Yasumasa , Kuwagaki Setsuka , Sakai Norihito , Matsusaki Michiya 
Published: February 2023

AbstractEmbedded extrusion printing provides a versatile platform for fabricating complex hydrogel‐based biological structures with living cells. However, the time‐consuming process and rigorous storage conditions of current support baths hinder their commercial application. This work reports a novel “out‐of‐the‐box” granular support bath based on chemically crosslinked cationic polyvinyl alcohol (PVA) microgels, which is ready to use by simply dispersing the lyophilized bath in water. Notably, with ionic modification, PVA microgels yield reduced particle size, uniform distribution, and appropriate rheological properties, contributing to high‐resolution printing. Following by the lyophilization and re‐dispersion process, ion‐modified PVA baths recover to its original state, with unchanged particle size, rheological properties, and printing resolution, demonstrating its stability and recoverability. Lyophilization facilitates the long‐term storage and delivery of granular gel baths, and enables the application of “out‐of‐the‐box” support materials, which will greatly simplify experimental procedures, avoid labor‐intensive and time‐consuming operations, thus accelerating the broad commercial development of embedded bioprinting.
Modified design of x‐ray protective clothing to enhance radiation protection for interventional radiologists
Authors: Choi Tae Won , Chung Jin Wook , Kwon Yohan 
Published: February 2023

AbstractBackgroundIn interventional radiology procedures, the operator typically stands on the right side of the patient's right thigh to manipulate devices through the femoral sheath. Because the standard x‐ray protective clothing is designed as sleeveless and scatter radiations from the patient are mainly incident from the left‐anterior direction to the operator, the arm hole of the clothing may be a significant unprotected area, contributing to an increase in the operator's organ doses and effective dose.PurposeThis study aimed to compare the organ doses and effective dose received by the interventional radiologist when wearing the standard x‐ray protective clothing and when wearing the modified clothing with an additional shoulder guard.MethodsThe experimental setup aimed to simulate actual clinical practice in interventional radiology. The patient phantom was located at the beam center to generate scatter radiation. An adult female anthropomorphic phantom loaded with 126 nanoDots (Landauer Inc., Glenwood, IL) was used to measure organ and effective doses to the operator. The standard wrap‐around type x‐ray protective clothing offered 0.25‐mm lead‐equivalent protection, and the frontal overlap area offered 0.50‐mm lead‐equivalent protection. The shoulder guard was custom‐made with a material providing x‐ray protection equivalent to lead of 0.50 mm thickness. The organ and effective doses were compared between the operator wearing the standard protective clothing and the one wearing the modified clothing with a shoulder guard.ResultsAfter adding the shoulder guard, doses to the lungs, bone marrow, and esophagus decreased by 81.9%, 58.6%, and 58.7%, respectively, and the effective dose to the operator decreased by 47.7%.ConclusionsWidespread use of modified x‐ray protective clothing with shoulder guards can significantly decrease the overall occupational radiation risk in interventional radiology.
Preparation of novel Polyvinylidene fluoride/boehmite composite membrane made using nonsolvent induced phase separation method for arsenate ion removal from water
Authors: Kumar Anil , Ghosh Uttam Kumar 
Published: February 2023

AbstractPolyvinylidene fluoride/boehmite composite membranes with hydrophilic surfaces were prepared using the nonsolvent induced phase inversion technique (NIPS) method to remove arsenate ions from water. The nanoparticles were added with different boehmite filler content. The contact angle of the bare membrane is 850, and it is reduced to 530, imparting hydrophilicity due to the presence of boehmite nanoparticles. The mechanical characteristics of the membranes have significantly improved. The BET and SEM results have shown that the average pore diameter gets reduced with boehmite addition, and surface area increases. Additionally, the use of nanoparticles enhanced the membranes' thermal stability. The nanofiltration unit is used to filter the arsenic‐contaminated water. The transmembrane pressure of ~4 bar is applied to all the membranes, and arsenic rejection; the flux of the membranes was calculated. The membrane has shown the highest rejection of 55% with a flux of 3.5659 L/m2.h.