bluuebunny/crossref_metadata_2025_split huggingface dataset:
Structural features of the Achilles tendon in men with dyslipidemia and atherosclerosis
Authors: Anikina A. V. , Shcherbakova L. V. , Nikitin Yu. P. , Ragino Yu. I. 
Published: February 2023

Highlights. A large number of studies are devoted to changes in connective tissues in persons with familial hypercholesterolemia. Studies that are focused on these changes in patients with dyslipidemia without family history of dyslipidemia are few, and most of them are based on ultrasound methods. The data presented in the article make it possible to timely assess the presence of minor changes in the Achilles tendons and thereby obtain additional information about the mechanism of lipid deposition in various tissues.Aim. To determine structural features of the Achilles tendon in men with dyslipidemia and atherosclerosis.Methods. The study included 138 men aged 45–65 years with or without atherosclerosis of the common carotid artery or the abdominal aorta and their aortic branches verified by multislice computed tomography.Results. In individuals with atherosclerosis, the frequency of calcification of the Achilles tendon was 2.5 times higher than in individuals without atherosclerosis. In individuals with carotid artery atherosclerosis, the cross-sectional area of the Achilles tendon was 1.2 times larger than in individuals with abdominal aortic atherosclerosis. In individuals with carotid artery atherosclerosis, the density of the Achilles tendon was 1.1 times higher than in individuals with abdominal aortic atherosclerosis. In individuals with carotid artery atherosclerosis, the frequency of calcification of the Achilles tendon was 2.0 times higher than in individuals with abdominal aortic atherosclerosis. An increase in the cross-sectional area of the tendon and its density, regardless of other factors, including the localization of the atherosclerosis, is directly associated with the total blood cholesterol. The presence of lipid and calcium deposition in the tendons, regardless of other factors, is directly associated with the total blood cholesterol and some of its fractions. The presence of lipid deposition in the tendons is inversely associated with the level of level of phosphate in the blood. The thickening of the tendon and the increase in its density is directly associated with the age of men.Conclusion. The study results revealed that persons with dyslipidemia and atherosclerosis present with changes in the connective tissues – in the structure of tendons, regardless of family history.
Recent advances in the biological activity of quinazoline
Authors: Nagrale Sudarshan , Pondkule Amit , Babar Vishal 
Published: February 2023

The aim of this review is to produce an outline of numerous pharmacologic activities of quinazoline moiety. Quinazoline has become a famous topic up of two fused six-membered simple aromatic rings, a benzene ring and a pyrimidine ring because of its manifold uses. various quinazoline derivatives have been found to gives a broad spectrum of biological activities, which stimulated the research activity in this field. Quinazolines and its derivatives represent one in all the foremost active categories of compounds, that possess wide selection of biological activities like anti-bacterial, analgesic, anti-microbial, anti-inflammatory drug, anticancer, and anti-hypertensive, antifungal, anti-HIV, inhibitor, analgesic, medicament, antiprotozoal, antitumor, anti-tubercular activities. This review is an effort to magnify the immense potentiality of this ring system. This study may accelerate the designing process to come up with a lot of range of therapeutically viable clinical candidates.
Healing of wounds in diabetic rats treated with Rosa rubiginosa oil
Authors: Nascimento Isadora , Pinheiro Gomes Maria Eduarda Pinheiro Gomes , Gomes Fernandes Naíla Esther , Medeiros Azevedo Ítalo , De Alcântara Oliveira Ramalho Borges Rachel , Cunha Medeiros Aldo 
Published: February 2023

PURPOSE: This study aimed to examine if Rosa rubiginosa oil (Rro) influences the healing of skin wounds of diabetic rats. METHODS: Four groups of Wistar rats were used (6 rats/group). Group 1: skin wounds were topically treated with normal saline (NS). Group 2 had skin wounds treated with Rro for 10 days. Diabetes was induced with Streptozotocin (STZ) in groups 3 and 4. Group 3 had the wounds treated with NS. The wounds of groups 4 were treated with Rro. After anesthesia, all rats had skin excisional wounds 0.8 cm diameter. On 10th day, blood glucose and wound tissue cytokines were measured. Histometry of wounds was studied. RESULTS: Glycemia levels of 3 an 4 group rats were >250 mg%. Diabetic and non diabetic rats treated with Rro had wound tissue TNF-α, IL-1β and IL-6 expression lower than in rats receiving NS. The histological inflammatory score of Rro treated diabetic rats (19±2.7) was significantly higher than in rats treatment with NS (14±2.5). CONCLUSION: The topical treatment of skin wounds in diabetic rats with Rosa rubiginosa oil positively influenced the healing.
Scapular Dyskinesis in the Athletic Patient
Authors: Sonnier John Hayden , Ciccotti Michael C. , Darius Danielle , Hall Anya T. , Freedman Kevin B. , Tjoumakaris Fotios 
Published: February 2023

» Scapular dyskinesis is an alteration of normal scapular kinematics. It is essential that each patient be evaluated holistically and that sport-related factors be taken into account.» The presentation of scapular dyskinesis may be highly variable depending on the underlying etiology or associated pathology, but the onset of symptoms is often gradual.» Sport-specific literature on scapular dyskinesis is most commonly reported in the context of baseball, swimming, and tennis. Treatment is most often conservative and involves physical therapy directed at the scapular stabilizers.
Void Fraction Measurement Method in Gas/Liquid Two-Phase Stratified Flow
Authors: Han Bangbang , Ge Bin , Faraj Yousef , Wang Xiaojie , Fang Lide 
Published: February 2023

Summary
The void fraction is a basic parameter to characterize the two-phase flow. Accurate measurement of its value is of great significance for industrial production. In this study, an optical correction system combined with software and hardware is developed. Stereoscopic particle image velocimetry (SPIV) technology is used to measure the void fraction in gas/liquid two-phase stratified flow. The measurement results are compared with those of 2D particle image velocimetry under the same conditions, and the correction effect appears to be reasonably good. The void fraction value is obtained by the image processing of the corrected image. The accuracy of the measurement results is verified by comparing the experimental liquid-phase volumetric flow rate with that measured through a standard flowmeter. Twenty types of void fraction prediction models are evaluated using the mean absolute relative deviation (MARD), root mean square error (RMSE), and gray correlation analysis methods. The results suggest that the Armand (1946) model has the smallest MARD, RMSE value, the largest correlation degree (Ri) value, and the best prediction performance. On this basis, an improved model is proposed by fitting the relationship between void fraction and gas volume holdup.
Long-term results of valgus intertrochanteric osteotomy for partial avascular necrosis of the femoral head after femoral neck fracture in adolescents
Authors: Chochola Antonín , Bartoníček Jan , Douša Pavel , Tuček Michal 
Published: February 2023

Abstract
Purpose: The study evaluates long-term results in patients treated by valgus intertrochanteric osteotomy (VITO) for partial avascular necrosis of the femoral head (ANFH) after fracture of the femoral neck in adolescent age. Although this method is mentioned in literature frequently, there are only few studies in the literature dealing with it in detail.
Methods: Authors evaluated five patients at the interval of 15 to 20 years following VITO. The mean age of the patients at the time of injury was 13.6 years and at the time of VITO 16.7 years. The studied parameters included resorption of necrotic segment of femoral head, development of posttraumatic osteoarthritis and leg shortening
Results:Comparison of radiographs and MRI scans before and after VITO showed resorption of the necrotic segment of the femoral head and its remodeling in all five patients. However, two patients gradually developed slight osteoarthritic changes. In one patient, remodeling of the femoral head occurred during the first 6 years postoperatively. Subsequently, the patient developed severe osteoarthritis with marked clinical symptoms.
Conclusion:VITO can improve the long-term function of the hip joint in adolescents with ANFH after a femoral neck fracture, but cannot restore completely the original shape and structure of the femoral head.
Spatial planning and management to control multi-ecological environmental problems: A case study of Anshan city, Liaoning, China
Authors: Zhang Tingshuang , Liu Miao , Li Chunlin , Chen Tan , Yin Hongyan , Du Yan 
Published: February 2023

Abstract
Spatial pattern and process studies are of global interest and typically focus on one certain environmental or ecological process, and the methods employed mostly rely upon spatial process models. Meanwhile, spatial planning is an important administrative management in regional development, especially in China. However, traditional urban planners focused more on social economy and less on eco-environment. How to conduct scientific planning is the key to solving and preventing eco-environmental problems. In this study, we proposed a synthetic spatial analysis and planning method that involves atmospheric, edaphic, hydrographic and ecological processes to zoning management and control strategies for regional sustainable goals. The method can identify key eco-environmental processes and regions effectively, divide scientific spatial control unit, and set precise management polices to prevent environmental pollution and ecological damage events. The synthetic method was conducted using advanced multi-process models and spatial statistical methods, including CMAQ and SWAT models. The case study in Anshan city indicated that the models we proposed can effectively reflect the link between pollutants and land use pattern. According to the process simulation results of pollutant distribution, we combined the administrative districts and land use, divided 67 types of eco-environmental management units based on atmospheric pollution discharge, hydrographic pollution discharge, edaphic heavy metal pollution, and ecological space. For each unit, we proposed feasible management policies and control measures. This synthetic method can provide scientific analysis and guidance support spatial planning and ecological construction for multi-purpose ecological environmental protection.
Accessory hepatic vein recanalization for Budd-Chiari syndrome: a systematic review and meta-analysis
Authors: Lv Lu-Lu , Xu Han-Bo , Li Sheng-Li , Xu Peng 
Published: February 2023

Abstract
Background
Budd-Chiari syndrome (BCS) results when the outflow of the hepatic vein (HV) is obstructed. BCS patients exhibiting an accessory HV (AHV) that is dilated but obstructed can achieve significant alleviation of liver congestion after undergoing AHV recanalization. This meta-analysis was developed to explore the clinical efficacy of AHV recanalization in patients with BCS.
Materials and Methods
PubMed, Embase, and Wanfang databases were searched for relevant studies published as of November 2022, and RevMan 5.3 and Stata 12.0 were used for pooled endpoint analyses.
Results
Twelve total studies were identified for analysis. Pooled primary clinical success, re-stenosis, 1- and 5-year primary patency, 1- and 5-year secondary patency, 1-year overall survival (OS), and 5-year OS rates of patients in these studies following AHV recanalization were 96%, 17%, 91%, 75%, 98%, 91%, 97%, and 96%, respectively. Patients also exhibited a significant reduction in AHV pressure after recanalization relative to preoperative levels (P < 0.00001). Endpoints exhibiting significant heterogeneity among these studies included, AHV pressure (I2 = 95%), 1-year primary patency (I2 = 51.2%), and 5-year primary patency (I2 = 62.4%). Relative to HC recanalization, AHV recanalization was related to a lower rate of re-stenosis (P = 0.002) and longer primary patency (P < 0.00001), but was not associated with any improvements in clinical success (P = 0.88) or OS (P = 0.29) relative to HV recanalization.
Conclusions
The present meta-analysis highlights AHV recanalization as an effective means of achieving positive long-term outcomes in patients affected by BCS, potentially achieving better long-term results than those associated with HV recanalization.
Improving paramedic responses for patients dying at home: a theory of change-based approach
Authors: Simpson Jane , Remawi Bader Nael , Potts Kieran , Blackmore Tania , French Maddy , Haydock Karen , Peters Richard , Hill Michael , Tidball Oliver-Jon , Parker Georgina , Waddington Michelle , Preston Nancy 
Published: February 2023

Abstract
Background
Paramedics are increasingly being called to attend patients dying from advanced incurable conditions. However, confidence to deal with such calls varies, with many feeling relatively unskilled in this aspect of their role. A number of interventions have been piloted to improve their skills in end-of-life care but without a fully specified theoretical model. Theory of change models can provide theoretical and testable links from intervention activities to proposed long-term outcomes and indicate the areas for assessment of effectiveness. This study aimed to develop an intervention for improving paramedic end-of-life care for patients in the community.
Methods
A theory of change approach was used as the overarching theoretical framework for developing an intervention to improve paramedic end-of-life skills. Relevant stakeholders - including specialist community paramedics, ambulance call handlers and palliative care specialists - were recruited to five consecutive online workshops. Over multiple workshops, stakeholders decided on the desired impact, short- and long-term outcomes, and possible interventions. During and between these workshops a theory of change model was created, with the components shared with stakeholders.
Results
The stakeholders agreed the desired impact was to provide consistent, holistic, patient-centred, and effective end-of-life care. Four potential long-term outcomes were suggested: 1) increased use of anticipatory and regular end-of-life medications; 2) reduced end-of-life clinical and medication errors; 3) reduced unnecessary hospitalisations; 4) increased concordance between patient preferred and actual place of death. Key interventions focused on providing immediate information on what to do in such situations including: appraising the situation, developing an algorithm for a treatment plan (including whether or not to convey to hospital) and how to identify ongoing support in the community.
Conclusions
A theory of change approach was effective at identifying impact, outcomes, and the important features of an end of life intervention for paramedics. This study identified the need for paramedics to have immediate access to information and resources to support end-of-life care, which the workshop stakeholders are now seeking to develop as an intervention.
Integrative analysis of immune infiltration and microenvironment characteristics in renal clear cell carcinoma induced by cell senescence
Authors: Zhang Xiangxiang , Wang Xiaoping , Li Hengping , Wang Xiangrong , Zhang Mao , Liu Yang , Li Xuanpeng 
Published: February 2023

Abstract
Background
Our study aims to investigate the characteristics of the tumor microenvironment as well as to study the immunological infiltration in renal clear cell carcinoma that results from cell senescence.
Methods
Firstly, based on information from the Cancer Genome Atlas (TCGA) database, we collected ccRCC's mRNA, clinical data, and mutation data. From the comprehensive gene expression database (GEO), we acquired individuals gene expression profiles and relevant clinical data with ccRCC. We obtained senescence genes from the Aging Atlas database, extracted the expression of senescence genes from TCGA and GEO databases, and subsequently analyzed the differences. After which, the Kaplan Meier (KM) survival rate was utilised to determine survival-related prognostic genes; Cross genes were obtained from the intersection of differential genes and prognostic genes. By utilising the least absolute shrinkage and selection operator (lasso) regression and cross-validation, the genes included in the construction of the prognostic model were identified. The risk score was detected based on the signature, and the sample was then categorized into high-risk and low-risk groups. GSEA enrichment analysis, immune checkpoint analysis and the expression degree analysis of each model gene in immune cells were conducted among high-risk group and low-risk group respectively. The model we built was validated using the IMvigor210 database. Finally, we screened drugs that can inhibit the expression of high-risk genes from the Connectivity Map (CMAP) database by using risk differential genes.
Results
We obtained 37 cross genes and identified 17 genes that could be used to construct prediction model. We found that the tumor mutation load was higher in the high-risk groups. Even though high-risk patients were more likely to evade immunotherapy, there was no significant difference between the two groups when treated with PD-1, CTLA-4, or PD-1, combined with CTLA-4 immunotherapy. The verification results of IMvigor210 database were compatible with the study outcomes. Finally, we screened 6 drugs that can inhibit the expression of high-risk genes from the CMAP database by using risk differential genes.
Conclusion
The tumor microenvironment of ccRCC induced by cell senescence may have an immune escape or resistance when receiving immunotherapy. These findings may have some guiding significance for clinical individualized immunotherapy.
Ketamine versus Etomidate for Rapid Sequence Intubation in Patients with Trauma: A Retrospective Study in a Level 1 Trauma center in Korea
Authors: Kim Jinjoo , Jung Kyoungwon , Moon Jonghwan , Kwon Junsik , Kang Byung Hee , Yoo Jayoung , Song Seoyoung , Bang Eunsook , Kim Sora , Huh Yo 
Published: February 2023

Abstract
Background
Ketamine and etomidate are commonly used as sedatives in rapid sequence intubation (RSI). However, there is no consensus on which agent should be favoured when treating patients with trauma. This study aimed to compare the effects of ketamine and etomidate on first-pass success and mortality in patients with trauma after RSI-facilitated emergency intubation.
Methods
We retrospectively reviewed 944 patients who underwent endotracheal intubation in a trauma bay at a Korean level 1 trauma centre between January 2019 and December 2021. Outcomes were compared between the ketamine and etomidate groups after propensity score matching to balance the overall distribution between the two groups.
Results
In total, 620 patients were included in the analysis, of which 118 (19.9%) were administered ketamine and the remaining 502 (80.1%) were treated with etomidate. Patients in the ketamine group showed a significantly faster initial heart rate (105.0 ± 25.7 vs. 97.7 ± 23.6, p = 0.003), more hypotensive (114.2 ± 32.8 mmHg vs. 139.3 ± 34.4 mmHg, p < 0.001), higher GCS (9.1 ± 4.0 vs. 8.2 ±4.0, P=0.031), and higher Injury Severity Score (32.5 ± 16.3 vs. 27.0 ± 13.3, p < 0.001) than those in the etomidate group. There were no significant differences in the first-pass success rate (90.7% vs. 90.1%, p > 0.999), mortality (16.1% vs. 20.6, p=0.348), ICU LOS (14.8 ± 31.9 vs. 14.8 ± 15.5, p = 0.998), ventilator days (9.0 ± 17.9 vs. 9.6 ± 12.2, p = 0.735), or hospital stay (31.0 ± 38.6 vs. 27.3 ± 22.9, p=0.322) in the 1:3 propensity score matching analysis.
Conclusion
During trauma resuscitation, ketamine was found to be the preferred sedative for patients who were hemodynamically unstable and conscious. However, there was no significant difference in clinical outcomes between patients sedated with ketamine and those treated with etomidate.
A Reconfigurable Graphene Patch Antenna Inverse Design at Terahertz Frequencies
Authors: Mashayekhi Mohammad , Kabiri Pooria , Nooramin Amir saman , Soleimani Mohammad 
Published: February 2023

Abstract
This article investigates the inverse design of a reconfigurable multi-band patch antenna based on graphene for terahertz applications to operate frequency range (2THz – 5THz). In the first step, this article evaluates the dependence of the antenna radiation characteristics on its geometric parameters and the graphene properties. The simulation results show that it is possible to achieve up to 8.8 dB gain, 13 frequency bands, and 360° beam steering. Then and due to the complexity of the design of graphene antenna, a deep neural network (DNN) is used to predict the antenna parameters by given inputs like desired realized gain, main lobe direction, half power beam width, and return loss in each resonance frequency. The trained DNN model predicts almost with 93% accuracy and 3% mean square error in the shortest time. Then, this network was used to design five-band and three-band antennas, and it has been shown that the desired antenna parameters are achieved with negligible errors. Therefore, the proposed antenna finds many potential applications in the THz frequency band.
An instantaneous comparison between the chemometrics-assisted spectrophotometric method and liquid chromatography, a technique for identifying antibiotics in their compounded dosage formulations
Authors: Jain Pritam , Patil Deepak 
Published: February 2023

Abstract

Our study used chemometric-based UV–visible spectrophotometry and Reversed-phase chromatography (habitually stated to as RP chromatography) methods to estimate the amounts of pharmacological dosage forms with a combination of ofloxacin and tinidazole. Quantifying each drug in mixtures was done using UV absorption spectra of 280 to 320 nm and ∆λ of 0.5 nm. For the development of the chemometric model, 24 binary mixture solutions were used, and for validation, twelve solutions were chosen. No prior separation is required for the chemometric-assisted analysis. RP-HPLC units were constructed for quantification by using a THERMOSIL C18 column, a 0.8 and 1.0 ml/min flow rate, and an 85% phosphate: 15% acetonitrile mobile phase. Using these methods, multiple drugs were determined simultaneously in a synthetic mixture. RP-HPLC had a good agreement with PCR and PLS results when compared with the PCR and PLS results.