bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of Multiple High-Risk Factors on Observed Outcomes in Real-World Patients With Advanced Ovarian Cancer Treated With First-Line Therapy
Authors: Chase Dana , Perhanidis Jessica , Gupta Divya , Kalilani Linda , Golembesky Amanda , González-Martín Antonio 
Published: June 2023

PURPOSE To identify risk factors for disease progression or death and assess outcomes by risk categories in real-world patients with advanced ovarian cancer. METHODS This retrospective study included adult patients from a nationwide electronic health record–derived deidentified database with stage III/IV ovarian cancer who received first-line therapy and had ≥12 weeks of follow-up after index date (end of first-line therapy). Factors predictive of time to next treatment and overall survival (OS) were assessed. Patients were grouped according to the cumulative number of high-risk factors present (stage IV disease, no debulking surgery or neoadjuvant therapy and interval debulking surgery, visible residual disease after surgery, and breast cancer gene [ BRCA] wild-type disease/unknown BRCA status), and time to next treatment and OS were assessed. RESULTS Region of residence, disease stage, histology, BRCA status, surgery modality, and visible residual disease were significant predictors of time to next treatment; age, Eastern Cooperative Oncology Group performance status, disease stage, BRCA status, surgery modality, visible residual disease, and platelet levels were significant predictors of OS (N = 1,920). Overall, 96.4%, 74.1%, and 40.3% of patients had at least 1, 2, or 3 high-risk factors, respectively; 15.7% of patients had all four high-risk factors. Observed median time to next treatment was 26.4 months (95% CI, 17.1 to 49.2) in patients with no high-risk factors and 4.6 months (95% CI, 4.1 to 5.7) in patients with four high-risk factors. Observed median OS was shorter among patients with more high-risk factors. CONCLUSION These results underscore the complexity of risk assessment and demonstrate the importance of assessing a patient's cumulative risk profile rather than the impact of individual high-risk factors. They also highlight the potential for bias in cross-trial comparisons of median progression-free survival because of differences in risk-factor distribution among patient populations.
Prevalence and Clinical Characteristics of PDX1 Variant Induced Diabetes in Chinese Early-Onset Type 2 Diabetes
Authors: Lian Hong , Gong Siqian , Li Meng , Wang Xirui , Wang Fang , Cai Xiaoling , Liu Wei , Luo Yingying , Zhang Simin , Zhang Rui , Zhou Lingli , Zhu Yu , Ma Yumin , Ren Qian , Zhang Xiuying , Chen Jing , Chen Ling , Wu Jing , Gao Leili , Zhou Xianghai , Li Yufeng , Zhong Liyong , Han Xueyao , Ji Linong 
Published: June 2023

Abstract

Context
Maturity-onset diabetes of the young 4 (MODY4) is caused by mutations of PDX1; its prevalence and clinical features are not well known.

Objective
This study aimed to investigate the prevalence and clinical characteristics of MODY4 in Chinese people clinically diagnosed with early-onset type 2 diabetes (EOD), and to evaluate the relationship between the PDX1 genotype and the clinical phenotype.

Method
The study cohort consisted of 679 patients with EOD. PDX1 mutations were screened by DNA sequencing, and their pathogenicity was evaluated by functional experiments and American College of Medical Genetics and Genomics guidelines. MODY4 was diagnosed in individuals with diabetes who carry a pathogenic or likely pathogenic PDX1 variant. All reported cases were reviewed for analyzing the genotype–phenotype relationship.

Result
4 patients with MODY4 were identified, representing 0.59% of this Chinese EOD cohort. All the patients were diagnosed before 35 years old, either obese or not obese. Combined with previously reported cases, the analysis revealed that the carriers of homeodomain variants were diagnosed earlier than those with transactivation domain variants (26.10 ± 11.00 vs 41.85 ± 14.66 years old, P &lt; .001), and the proportions of overweight and obese individuals with missense mutation were higher than those with nonsense or frameshift mutations (27/34 [79.4%] vs 3/8 [37.5%], P = .031).

Conclusion
Our study suggested that MODY4 was prevalent in 0.59% of patients with EOD in a Chinese population. It was more difficult to identify clinically than other MODY subtypes owning to its clinical similarity to EOD. Also, this study revealed that there is some relationship between genotype and phenotype.
NEAT1_2/RRAD/EHF Positive Feedback Loop Facilitates Aerobic Glycolysis in Papillary Thyroid Cancer Cells
Authors: Sun Wei , Wang Zhiyuan , Qin Yuan , Ji Xiaoyu , Huang Jiapeng , Zhang Fan , Wang Zhihong , Dong Wenwu , He Liang , Zhang Hao 
Published: June 2023

Abstract
Papillary thyroid carcinoma (PTC) is the most prevalent endocrine-related malignancy. In spite of the good prognosis, a more aggressive disease can develop in some PTC patients, leading to poor survival. Nuclear paraspeckle assembly transcript 1 (NEAT1) enhances tumorigenesis; however, the relationship between NEAT1_2 and glycolysis in PTC has not been identified. The expressions of NEAT1_2, KDM5B, Ras-related associated with diabetes (RRAD), and EHF were determined by quantitative reverse transcription polymerase chain reaction and immunocytochemistry. The effects of NEAT1_2, KDM5B, RRAD, and EHF on PTC glycolysis were ascertained employing in vitro as well as in vivo experiments. Chromatin immunoprecipitation (ChIP), RNA binding protein immunoprecipitation, luciferase reporter assays, and co-immunoprecipitation were utilized to analyze the binding abilities among NEAT1_2, KDM5B, RRAD, and EHF. Overexpression of NEAT1_2 was associated with glycolysis in PTC. NEAT1_2 could activate glycolysis by regulating the expression of RRAD in PTC. NEAT1_2 mediated H3K4me3 modification at the promoter of RRAD by recruiting KDM5B. RRAD further negatively regulated glycolysis by binding and regulating the subcellular location of the transcription factor EHF. EHF could activate the transcription of NEAT1_2, hexokinase 2, and pyruvate kinase M2, thereby forming the NEAT1_2/RRAD/EHF feedback loop. Our study revealed that the NEAT1_2/RRAD/EHF positive feedback loop facilitated glycolysis in PTC, which might avail meaningful insight for PTC management.
Parabens Promote Protumorigenic Effects in Luminal Breast Cancer Cell Lines With Diverse Genetic Ancestry
Authors: Tapia Jazma L , McDonough Jillian C , Cauble Emily L , Gonzalez Cesar G , Teteh Dede K , Treviño Lindsey S 
Published: June 2023

Abstract

Context
One in 8 women will develop breast cancer in their lifetime. Yet, the burden of disease is greater in Black women. Black women have a 40% higher mortality rate than White women, and a higher incidence of breast cancer at age 40 and younger. While the underlying cause of this disparity is multifactorial, exposure to endocrine disrupting chemicals (EDCs) in hair and other personal care products has been associated with an increased risk of breast cancer. Parabens are known EDCs that are commonly used as preservatives in hair and other personal care products, and Black women are disproportionately exposed to products containing parabens.

Objective
Studies have shown that parabens impact breast cancer cell proliferation, death, migration/invasion, and metabolism, as well as gene expression in vitro. However, these studies were conducted using cell lines of European ancestry; to date, no studies have utilized breast cancer cell lines of West African ancestry to examine the effects of parabens on breast cancer progression. Like breast cancer cell lines with European ancestry, we hypothesize that parabens promote protumorigenic effects in breast cancer cell lines of West African ancestry.

Methods
Luminal breast cancer cell lines with West African ancestry (HCC1500) and European ancestry (MCF-7) were treated with biologically relevant doses of methylparaben, propylparaben, and butylparaben.

Results
Following treatment, estrogen receptor target gene expression and cell viability were examined. We observed altered estrogen receptor target gene expression and cell viability that was paraben and cell line specific.

Conclusion
This study provides greater insight into the tumorigenic role of parabens in the progression of breast cancer in Black women.
Introduction
Authors: Banerjee Anindita , Safran Gabriella 
Published: June 2023

AbstractThis special issue provokes a radical reconsideration of the pasts and futures of world literature thirty years after the dissolution of the Soviet Union, accompanied by triumphalist declarations of the end of history. Conceived in the wake of racial justice protests in the summer of 2020 and completed amid the invasion of Ukraine in 2022—two events with global reverberations that decisively punctured the illusions of a post-imperial, post-socialist, and post-racial world order homogenized by the unfettered spread of neoliberal capitalism—the articles collected here return to the prehistories and afterlives of a distinct body of transnational, transregional, and transmedian works that emerged from a shared desire to think beyond racial capitalism and socialism conceived within narrow ethnocentric and geopolitical frameworks. Looking backward and forward from the turn of the twentieth century to the present and beyond, they present new theoretical approaches and critical toolkits for what we call the literature of socialist anti-racisms. The connected histories of socialist anti-racist literature, however, were far from unadulterated dreamworlds of solidarity and emancipation; its inherent contradictions, visible on the very surfaces of the texts and contexts examined by our authors, assume particularly nightmarish contours from the vantage point of our shared, violent present.
Civilizational Myth and Class Politics
Authors: Chu Jinyi 
Published: June 2023

AbstractWhat is the connection between class and race? Socialist revolutionaries in early twentieth-century Russia engaged with this question in their political essays. The imperial partition of China and the construction of the Trans-Siberian Railway made the China question one of the most topical issues in Russia. This article examines Lenin’s essays on China in which he criticizes racist ideas popular in Russia and Europe. By comparing his essays with other Russian political commentaries on China, this article argues that Lenin views racism as a matter of political economy and global class politics. On the one hand, the myth of racial rivalry and clash of civilizations veils class struggle. On the other, racial and ethnic issues complicate class politics. Lenin’s critique of racism elaborated in the discussion of wars and revolutions in China is not a dogmatic extension of Marx, but directly addresses the transnational migration, geopolitical tension, and intellectual network.
Ethnoracial Utopianism and Speculative Aesthetics after the End of History
Authors: Vint Sherryl 
Published: June 2023

Abstract
Using a reading of Hari Kunzru’s novel Red Pill to frame our contemporary political moment, this article asks what techniques of cultural critique are available to the Left today when the strategies of imaginary worldbuilding have become so central to the ethnonationalist politics of the Right. It argues that the end of the Cold War prompted a reconfiguration of political identities and public discourse in both the West and the former Soviet territories—through distinct but interrelated logics—that highlighted the failures of liberalism in ways that set the stage for the mainstream return of fascist politics of white supremacy. In this context of alternative histories taken as fact, of conspiracy rhetoric seemingly impervious to reason, this article asks how we can respond in intellectually robust ways that will help us to ground an inclusive culture and build a better future, practices the author situates in the broad field of Marxist-informed utopian studies.
Whither Trans Studies?
Authors: Amin Kadji 
Published: June 2023

Abstract
In the face of incisive and important critiques by Andrea Long Chu, Emmett Harsin Drager, Che Gossett, and Eva Hayward, this article proposes that trans studies is a field at a crossroads. It can slide further into irrelevance by continuing to promote trans- as an abstract prefix of crossing, or it can become relevant to trans people by focusing on the material heterogeneity of trans populations, histories, and epistemologies. The article sketches out some of the rich and exciting directions the latter inquiry could take. With reference to particularly generative proposals by graduate students in this issue, it argues that trans and gender-variant life is a more than sufficient basis for the field.
Chapter Eight: Toxic Colonialism, Alienation, and Posthuman Dystopia in Chen Qiufan
Authors: Wang Ban 
Published: June 2023

Abstract
Chen Qiufan's sci-fi novel Waste Tide attests to the dual alienation of nature and humans. Global capitalism, geopolitical conflict, the scramble for natural resources, and rash development have destroyed the rural community, ruined the health of local populations, and eroded the natural environment. Technical advances—artificial intelligence, brain-computer interface, biochemical technologies, and cyborg construction—aggravate metabolic rifts in the human-nature relations, threatening human bodies, regional culture, and local traditions. Driven by profit motives and the desire for power, the advanced technologies are accelerating the alienation of humans from their bodies, from one another, and from nature.
Sex-specific transgenerational plasticity: developmental temperatures of mothers and fathers have different effects on sons and daughters
Authors: Seebacher Frank , Bamford Stephanie M. , Le Roy Amelie 
Published: June 2023

ABSTRACT
Each parent can influence offspring phenotype via provisioning of the zygote or sex-specific DNA methylation. Transgenerational plasticity may therefore depend on the environmental conditions experienced by each parent. We tested this hypothesis by conducting a fully factorial experiment across three generations of guppies (Poecilia reticulata), determining the effects of warm (28°C) and cold (21°C) thermal backgrounds of mothers and fathers on mass and length, and thermal performance (sustained and sprint swimming speeds, citrate synthase and lactate dehydrogenase activities; 18, 24, 28, 32 and 36°C test temperatures) of sons and daughters. Offspring sex was significant for all traits except for sprint speed. Warmer mothers produced sons and daughters with reduced mass and length, and warmer fathers produced shorter sons. Sustained swimming speed (Ucrit) of male offspring was greatest when both parents were raised at 28°C, and warmer fathers produced daughters with greater Ucrit. Similarly, warmer fathers produced sons and daughters with greater metabolic capacity. We show that the thermal variation experienced by parents can modify offspring phenotype, and that predicting the impacts of environmental change on populations would require knowledge of the thermal background of each mother and father, particularly where sexes are spatially segregated.
Curtailing Bank Loan and Loan Insurance Under Risk Regulations in Supply Chain Finance
Authors: Wang Wenli , Cai Gangshu (George) 
Published: June 2023

Because of many firms’ lack of collateral, banks have imposed loan limits as a form of risk-control regulations of bank financing. In response, loan insurance has emerged as a useful instrument to lift loan limits. To study the joint value of bank loans and loan insurance, this article investigates a supply chain composed of one supplier and one capital-constrained buyer who takes out a bank loan and potentially purchases loan insurance. The analysis reveals that both the supplier and the buyer can benefit from the bank financing with loan insurance in an insurance-cooperation region wherein the supplier is willing to reduce the wholesale price to entice the buyer to purchase insurance. Further still, in the insurance-cooperation region, worse contract terms of the bank loan benefit the supplier, whereas worse policy terms of loan insurance help the buyer. Such benefits can lead to a higher order quantity than the capital-abundant one and partially coordinate the entire supply chain. However, when production cost is low, the supplier and the buyer can encounter a Stackelberg prisoner’s dilemma, in which both firms no longer cooperate with each other, and both are worse off. Nevertheless, a government subsidy for the insurance premium can not only reduce the Stackelberg prisoner’s dilemma, but also improve the social welfare although it is not always optimal for the government to provide that subsidy. The main qualitative results are robust in a variety of extensions. This paper was accepted by Jayashankar Swaminathan, operations management. Funding: The first author acknowledges support from the National Natural Science Foundation of China (NSFC) [Grant 72171162] and the Humanity and Social Science Youth Foundation of Ministry of Education of China [Grant 20YJC630148], and the second author acknowledges support from the NSFC [Grant 72232001]. Supplemental Material: The online appendix and data are available at https://doi.org/10.1287/mnsc.2023.4827 .
Consent, assent and randomised evaluations
Authors: Sanders Michael , Summers Jack , Hirneis Vanessa , Hume Susannah , McGannon Gabrielle 
Published: June 2023

Background:Randomised trials have been on the rise in social policy over the last decade and a half, particularly in areas working with young people and vulnerable adults. Informed consent is an important principle for ethics committees governing research conducted by universities.
Aims and objectives:We consider the arguments for and against opt-in consent by parents, and opt-out assent, when it comes to trials taking place, particularly in schools.
Methods:We review what is known about this from a methodological standpoint.
Findings:We find that extant evidence suggests that requiring opt-in consent, rather than assent, to participation, risks reducing the ethical standards of trials by minimising participation; and by potentially risking disclosure of sensitive information about a child’s life to their parents. Moreover, there are important equity considerations, with more vulnerable groups likely to be excluded from research findings under an opt-in framework.
Discussion and conclusion:We conclude that the ethical argument for assent rather than consent is compelling under some circumstances, and should be considered on a case-by-case basis. Precautions must always be taken to safeguard participants.
Effect of Healthy Transitions intervention in improving family planning uptake among adolescents and young women in Western Nepal: A pre-and post-intervention study
Authors: Thakuri Dipendra Singh , Bhandari Rajan , Khatri Sangita , Dhungana Adhish , Balami Roma , Hanson-Hall Nana Apenem 
Published: June 2023

Background
Contraceptive use can prevent unintended pregnancies, early childbearing, and abortion-related deaths. Despite these benefits, the use of modern contraceptives remains low among adolescent girls and young women (AGYW) in Nepal. To address this gap, the Healthy Transitions Project was implemented in Karnali Province, Nepal from February 2019 to September 2021. This study aimed at measuring the effect of Healthy Transitions’ intervention on improving knowledge and use of modern family planning methods among AGYW in Nepal.

Methods
We used a pre- and post-intervention study design to assess the effect of Healthy Transitions project. A quantitative survey was conducted at baseline and after the first cohort of AGYW had completed the intervention (1 year later). The baseline survey was conducted in 2019 with a cohort of 786 married and unmarried AGYW aged 15–24 years. An end line survey was conducted in 2020 with 565 AGYW who were interviewed at baseline. Data analysis was done using STATA version 15.1. The exact McNemar significance probability value was used to decide the significance of difference between baseline and endline.

Results
The knowledge and uptake of modern family planning methods have increased in the endline compared to the baseline. AGYW recognised 10 out of the ten modern methods at endline, a significant increase from 7 at baseline (p<0.001). Among AGYW, 99% were aware of sources to obtain family planning methods, compared with 92% at baseline (p< 0.001). The proportion of married AGYW using modern contraceptive methods was significantly higher at the endline 33%, than baseline (26%) (p<0.001).

Conclusion
Our results show that multilevel demand and supply-side interventions, targeting adolescents and young women, their families, community, and health system helped to improve knowledge and use of modern family planning methods among AGYW. The study suggests that these intervention approaches can be adopted to improve family planning use among adolescents and young women in other similar settings.
Video-based teach-to-goal intervention on inhaler technique on adults with asthma and COPD: A randomized controlled trial
Authors: Al-Kharouf Mohammad Samer , Abdeljalil Mariam Hantash , Obeidat Nathir M. , Oweidat Khaled Al , Awwad Oriana 
Published: June 2023

Background
Incorrect use of inhalers is a problem associated with poor patient outcomes. Despite improvement in the technique after verbal educations, this deteriorates over-time requiring re-enforcement through different educative strategies. This study aimed to assess the impact of a novel video-based teach-to-goal (TTG) educational intervention on: mastery of inhaler technique, disease control, medication adherence and disease-related quality of life (QoL) over-time among asthma and COPD patients.

Methods
This prospective, open-label, randomized controlled trial was registered in ClinicalTrials.gov: Identifier NCT05664347. After baseline assessment participants received either a verbal (control group) or a video-based (intervention group) TTG strategy. After 3-month the intervention was assessed for impact on the intended outcomes. Inhaler technique was assessed using standardized checklists, disease control using the Asthma control test and COPD assessment test respectively for asthma and COPD patients while adherence using the Morisky Green Levine scale. For QoL, the mini asthma quality of life questionnaire and the St. George respiratory questionnaire were used for asthmatic and COPD patients, respectively. Differences in outcomes between intervention-control groups were analyzed using either Chi-Square (X2)/Fisher Exact or Mann Whitney test. The impact of intervention on outcomes over-time was examined using either McNemar or Wilcoxon test.

Results
At baseline, intervention (n = 51) and control (n = 52) groups had comparable demographic/clinical characteristics. At follow-up, inhaler technique improved among intervention group compared to control group (93.4% vs 67%) and to baseline (93.4% to 49.5%), (P<0.05). Similarly, medication adherence ameliorated among the intervention group in comparison to control group (88.2% to 61.5%) and to baseline (88.2% to 66.7%), (P<0.05). In regards to disease control, results showed an amelioration among the intervention group compared to baseline (35.3% to 54.9%) (P<0.05). QoL scores improved significantly among asthma patients (intervention group) at follow-up vs baseline. Better scores were also observed for COPD patients compared to controls, (P<0.05).

Conclusion
Video-based (TTG) was effective in enhancing inhaler technique over time as well as improving disease control, medication adherence, and QoL.

Trial registration
ClinicalTrials.gov: NCT05664347. https://clinicaltrials.gov/ct2/show/NCT05664347.
Italia–Russia: Un secolo di cinema, Italija–Rossija: Vek kino, Olga Strada and Claudia Olivieri (eds) (2020)
Authors: Paranyuk Viktoria 
Published: June 2023

Review of: Italia–Russia: Un secolo di cinema, Italija–Rossija: Vek kino, Olga Strada and Claudia Olivieri (eds) (2020)
Moscow: ABCDesign and PBN Print, 416 pp.,
ISBN 978-5-91103-558-7, h/bk, price unavailable