bluuebunny/crossref_metadata_2025_split huggingface dataset:
Understanding the role of organizational agility in the context of digital transformation: an integrative literature review
Authors: Gong Cheng , Ribiere Vincent 
Published: February 2023

Purpose
The purpose of this paper is to clarify the conceptual confusion in the extant literature about organizational agility and explore its role in different relationships in the context of digital transformation.

Design/methodology/approach
An integrative review of the relevant literature on agility was conducted. The literature on organizational agility and other variables in recent quantitative research was also examined to explore its role in different relationships.

Findings
Organizational agility is the ability to quickly respond and proactively embrace unanticipated changes in dynamic environments through effective resource reconfiguration and rapid decision-making. The role of organizational agility in achieving digital transformation has not been addressed from a holistic conceptual perspective. This paper addresses that gap and proposes that organizational agility is the underlying mechanism for an organization to fully use and engage its workforce, operation and network in the process of digital transformation.

Research limitations/implications
This research is an integrative review of the existing literature on the concept of agility and its relationships. The next phase of research needed for theory building will be the operationalization of constructs.

Practical implications
Organizations should strive to strategically develop both the reactivity and proactivity sides of organizational agility in achieving digital transformation that involves fundamental changes at different levels of the organization.

Originality
This paper explores the role of organizational agility in digital transformation through an integrative review of the relevant literature.
Discussing Patients in Private and in Print: The Records of an Eighteenth‐Century Dispensary
Authors: Cunynghame Daisy 
Published: February 2023

AbstractThis essay studies the variation between the ways in which physicians wrote about their patients in private and their presentation of these case histories to the wider world in print. Focusing particularly on the case of Andrew Duncan, who founded the Edinburgh Public Dispensary in 1776, this paper will investigate the differences detailed in Duncan's handwritten case notes with the ways in which he chose to portray these patient cases in his published works. This paper will argue that not only does Duncan demonstrate a tendency to exaggerate the positive outcomes from his treatments but also his published works simplify the diagnoses performed on dispensary patients. The self‐editing which is apparent in his medical publishing includes the omission of details of the range of complaints individual patients suffer from and exclusion of certain disease categories, including hysteria, from the printed record. This paper will argue that a historiographical focus on printed material such as disease studies and annual reports can result in the distortion of information regarding diagnosis, medical outcomes, and the relationship between patient and practitioner during the eighteenth century.
Medicating Georgia: Writing Doctors in the Old South
Authors: Ingram Allan 
Published: February 2023

AbstractThis essay looks at two medical families in Georgia between the eighteenth and nineteenth centuries, the Kollocks from Savannah and the Fort family from Milledgeville. Lemuel Kollock (1766–1823) moved there in 1792 from Connecticut to set up a medical practice. He married and had two sons and a daughter (Phineas, 1804–1872; Mary, 1806–1885; and George, 1810–1894). Phineas became a doctor and returned south after qualifying to practise in Savannah. The correspondence covers the social and professional contexts of practice, as well as the challenges of life and work in a climate like Georgia. A striking picture emerges of the place and importance of medicine in people's lives. Tomlinson Fort (1787–1859) was a native Georgian who set up in medicine in Milledgeville in 1810. He developed a wider public profile than Kollock, both as a doctor and in banking and politics. Most significantly, he published in 1849 his Dissertation on the Practice of Medicine, written in clear jargon‐free English, which gives a detailed and practical perspective on health in the deep South. These surviving writings allow us to examine the place of medicine within the distinctive conditions of the society of the time.
‘Make the Medick Art my Whole Concern’: Poetry as Women's Literary Medical Practice
Authors: Blackwood Ashleigh 
Published: February 2023

AbstractThe act of writing has long been acknowledged as integral to eighteenth‐century medical practice, with medical practitioners relying on their ability to communicate via the written word for professional success. Partly as a result of their literary activities, the achievements of male physicians, surgeons, and apothecaries are frequently well‐documented, yet the same cannot be said of women engaging in medical work. This essay argues that eighteenth‐century women's medical practice extended into their creative writing, with numerous women writers utilising poetry as a central form of authoritative expression on matters of health. Verse offered opportunities to scrutinise, advise on, and influence medical knowledge and practice. Print and manuscript works by authors Jane Barker (1652‐1732), Martha Hodges (fl.1675‐1725), and Susanna Blamire (1747‐94), serve a variety of functions, including arguing for women's medical education, reimagining the workings of the body, and advocating holistic forms of practice that unite physical and emotional forms of care.
‘Meanders of [the] Purple Flood’: Blood and Bloodletting in Eighteenth‐Century Literature and Medicine
Authors: Meek Heather 
Published: February 2023

AbstractThis essay considers understandings and representations of blood and bloodletting in a range of eighteenth‐century medical and literary texts. Reflecting a historical moment of complex and uneven transition, these texts present models of blood that are variously orthodox, idiosyncratic, and imaginative. Representations of bloodletting, in particular, show doctors and laypeople, including women, contesting, welcoming, and orchestrating the therapy, which could both injure and soothe. Taken together, the texts this essay explores reinforce, refute, and enlarge humoral, mechanist, rational–empirical, vitalist, and other master paradigms, commonly conceiving body, mind, spirit, and earth as intricately connected and illustrating how medical ideas in this period were formed not merely through the consensus of an elite group of male authorities but also through the co‐existence of a range of variable, oftentimes conflicting, theories; through dissent and debate; through the voices of non‐experts; and through a reliance on the creative imagination.
‘The Doctor and Devil’: The Literary Writing of Slave‐Ship Surgeons
Authors: Faubert Michelle 
Published: February 2023

AbstractIn the annals of writing by physicians from the long eighteenth century, there exists a neglected subset that demands greater attention: the writing of slave‐ship surgeons. Such physicians existed on many slave ships, and they were required to attend the crew and kidnapped Africans during the Middle Passage to the colonies. They were also required to keep meticulous records, which became the basis for some of the most powerful evidence brought to bear by parliamentary committees tasked with investigating the slave trade in Britain. I argue that the literary productions of slave‐ship surgeons, such as Thomas Trotter's Sea‐Weeds (1829) and Thomas Boulton's The Sailor's Farewell (1768), can also shed light on their experiences. The writings of slave‐ship surgeons offer an intriguing glimpse into the cognitive dissonance these doctors felt in answering their calling in circumstances designed to undermine its basic principle: to treat and foster human life.
Fish species lifespan prediction from promoter cytosine‐phosphate‐guanine density
Authors: Budd Alyssa M. , Mayne Benjamin , Berry Oliver , Jarman Simon 
Published: February 2023

AbstractLifespan is a key attribute of a species' life cycle and varies extensively among major lineages of animals. In fish, lifespan varies by several orders of magnitude, with reported values ranging from less than 1 year to approximately 400 years. Lifespan information is particularly useful for species management, as it can be used to estimate invasion potential, extinction risk and sustainable harvest rates. Despite its utility, lifespan is unknown for most fish species. This is due to the difficulties associated with accurately identifying the oldest individual(s) of a given species, and/or deriving lifespan estimates that are representative for an entire species. Recently it has been shown that CpG density in gene promoter regions can be used to predict lifespan in mammals and other vertebrates, with variable accuracy across taxa. To improve accuracy of lifespan prediction in a non‐mammalian vertebrate group, here we develop a fish‐specific genomic lifespan predictor. Our new model includes more than eight times the number of fish species included in the previous vertebrate model (n = 442) and uses fish‐specific gene promoters as reference sequences. The model predicts fish lifespan from genomic CpG density alone (measured as CpG observed/expected ratio), explaining 64% of the variance between known and predicted lifespans. The predictions are highly robust to variation in genome quality and are applicable to all classes of fish; a taxonomically diverse and speciose group. The results demonstrate the value of promoter CpG density as a universal predictor of fish lifespan that can applied where empirical data are unavailable, or impracticable to obtain.
Budding uninhibited by benzimidazoles 1 overexpression is associated with poor prognosis and malignant phenotype: A promising therapeutic target for lung adenocarcinoma
Authors: Chen Rui , Wang Zhiping , Lu Tianzhu , Liu Yuzhen , Ji Yulong , Yu Yilin , Tou Fangfang , Guo Shanxian 
Published: February 2023

AbstractBackgroundThe budding uninhibited by benzimidazoles (BUB) family is involved in the cell cycle process as mitotic checkpoint components. Abnormal proliferation is a vital process in the development of lung adenocarcinoma (LUAD). Nevertheless, the roles of BUB1 in LUAD remain unclear. In this study, we evaluated the prognostic value and biological functions of BUB1 in LUAD using data from The Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO), clinical LUAD samples, and in vitro experiments.MethodsThe expression, prognostic significance, functions, immune infiltration, and methylation of BUB1 in LUAD were comprehensively analyzed using TCGA, GEO, Gene Expression Profiling Interactive Analysis, Metascape, cBioPortal, MethSurv, and cancerSEA databases. Furthermore, we performed a battery of in vitro experiments and immunohistochemistry (IHC) to verify the bioinformatics results.ResultsMultivariate analysis revealed that BUB1 overexpression was an independent prognostic factor (hazard ratio = 1.499, p = 0.013). Functional enrichment analysis showed that BUB1 was correlated with cell cycle, proliferation, DNA repair, DNA damage, and invasion (p < 0.05). Finally, in vitro experiments showed that downregulation of BUB1 inhibited the proliferation, migration, and invasion of LUAD cells and promoted LUAD cell apoptosis. IHC also showed that BUB1 was overexpressed in LUAD (p < 0.001) and was significantly associated with poor prognosis (p < 0.001).ConclusionsOur bioinformatics and IHC analyses revealed that BUB1 overexpression was an adverse prognostic factor in LUAD. In vitro experiments demonstrated that BUB1 promoted tumor cell proliferation, migration, and invasion in LUAD. These results indicated that BUB1 was a promising biomarker and potential therapeutic target in LUAD.
The relation between trait flow and engagement, understanding, and grades in undergraduate lectures
Authors: Smith Alyssa C. , Ralph Brandon C. W. , Smilek Daniel , Wammes Jeffrey D. 
Published: February 2023

AbstractBackgroundMuch work has focused on inattention in the classroom, examining how episodes of task‐unrelated thought (i.e., mind wandering) and engagement with various forms of media (e.g., media multitasking, smartphone use) influence retention of lecture material. However, considerably less work has examined factors that may positively influence attentiveness in lectures.AimsWe aimed to explore whether the trait‐level tendency to experience ‘flow’—defined here as the subjective experience of deep and effortless concentration—is related to in‐class reports of engagement and understanding during undergraduate lectures, as well as academic performance.SampleParticipants were undergraduate students in Psychology at a University in Ontario, Canada.MethodsWe measured trait flow (i.e., deep, effortless concentration) at the beginning of each semester, and assessed engagement and understanding during lectures via experience sampling probes throughout two semesters in several university courses. Experience sampling probes were presented intermittently using a laptop application. We also measured students' trait mind wandering and grit, and collected students' course grades.ResultsThe general tendency to experience deep, effortless concentration predicted engagement and understanding in lectures throughout the term, as well as final course grades, over and above students' grittiness and tendency to mind wander.ConclusionsThese findings suggest that the everyday tendency to experience flow extends to a classroom environment and has implications for academic success.
Daratumumab, bortezomib and dexamethasone at first relapse for patients with multiple myeloma: A real‐world multicentre UK retrospective analysis
Authors: McMillan Annabel , Basu Supratik , Karunanithi Kamaraj , Parkins Elizabeth , Lau Edward Yan Ming , Cook Gordon , Parrish Christopher , Al‐Kaisi Firas , Pratt Guy , Shafeek Salim , Jenkins Stephen , Memon Danish , Bygrave Ceri , Papanikolaou Xenofon , Maisel Tara , Hassan Sandra , Moosai Shivir , Chander Gurvin , Rakesh Pallav , Kishore Bhuvan , Karim Farheen , Talbot Georgina , Wandroo Farooq , Yong Kwee , Popat Rakesh 
Published: February 2023

SummaryDaratumumab, bortezomib and dexamethasone (DVd) is approved for patients with relapsed multiple myeloma following the CASTOR phase 3 clinical trial. This retrospective multicentre analysis assesses the overall response rate (ORR) and progression‐free survival (PFS) in routine clinical practice for patients at first relapse treated with DVd incorporating weekly bortezomib. Data were collected from 296 sequential patients treated across 15 UK centres. After a median follow‐up of 21 months, the ORR was 82% (26% partial response, 56% very good partial response or better) and the median PFS was 16 months [95% confidence interval (CI) 12–20 months]. Results were similar regardless of prior lenalidomide exposure. The median time to next treatment was 20 months (95% CI 15–25 months) and the estimated overall survival at two years was 74%. Patients with high‐risk features (by cytogenetics, International Staging System or extramedullary disease) and those treated within 18 months of initiation of progression‐free treatment, or within 12 months of autologous stem cell transplant, had significantly inferior outcomes. The grade 2 and 3 peripheral neuropathy rate was 7%. DVd with weekly bortezomib was effective in a heterogenous real‐world population at first relapse with a low rate of peripheral neuropathy. However, high‐risk patients had inferior outcomes and should be considered for alternative treatments.
The roles of moral sensitivity and father presence on the relationship between violent video game exposure and aggression among left‐behind adolescents
Authors: Li Jiayu , Zhang Xiaoli , Du Qian , Zhan Danni , Gao Xuemei 
Published: February 2023

AbstractThis cross‐sectional study explored the relationship between violent video game exposure (VVGE) and aggression in left‐behind adolescents (LBAs) in China, taking into account the effects of moral sensitivity and father presence. A cluster sampling design was applied in this study; we recruited 615 adolescents (45.85% male, age range 12–18 years, Mage = 14.70 years, SD = 1.66) from China. The results by using SPSS 25.0 and the PROCESS macro showed that VVGE was positively associated with LBAs' trait aggression and its items, and moral sensitivity played a partial mediating role in these relationships. Moreover, father presence moderated VVGE and LBAs' trait aggression, verbal aggression and hostility. Specifically, at a high level of father presence, the direct effect of VVGE on trait aggression was significantly moderated by increasing the level of father presence, whereas this moderating effect was not significant at a low level of father presence. The results were similar for verbal aggression and hostility. Thus, moral sensitivity and father presence should be considered in prevention and intervention strategies aimed at reducing LBAs' aggression.
Species distributions models may predict accurately future distributions but poorly how distributions change: A critical perspective on model validation
Authors: Piirainen Sirke , Lehikoinen Aleksi , Husby Magne , Kålås John Atle , Lindström Åke , Ovaskainen Otso 
Published: February 2023

AbstractAimSpecies distribution models (SDMs) are widely used to make predictions on how species distributions may change as a response to climatic change. To assess the reliability of those predictions, they need to be critically validated with respect to what they are used for. While ecologists are typically interested in how and where distributions will change, we argue that SDMs have seldom been evaluated in terms of their capacity to predict such change. Instead, typical retrospective validation methods estimate model's ability to predict to only one static time in future. Here, we apply two validation methods, one that predicts and evaluates a static pattern, while the other measures change and compare their estimates of predictive performance.LocationFennoscandia.MethodsWe applied a joint SDM to model the distributions of 120 bird species in four model validation settings. We trained models with a dataset from 1975 to 1999 and predicted species' future occurrence and abundance in two ways: for one static time period (2013–2016, ‘static validation’) and for a change between two time periods (difference between 1996–1999 and 2013–2016, ‘change validation’). We then measured predictive performance using correlation between predicted and observed values. We also related predictive performance to species traits.ResultsEven though static validation method evaluated predictive performance as good, change method indicated very poor performance. Predictive performance was not strongly related to any trait.Main ConclusionsStatic validation method might overestimate predictive performance by not revealing the model's inability to predict change events. If species' distributions remain mostly stable, then even an unfit model can predict the near future well due to temporal autocorrelation. We urge caution when working with forecasts of changes in spatial patterns of species occupancy or abundance, even for SDMs that are based on time series datasets unless they are critically validated for forecasting such change.
Threat and challenge: Holocaust survivors, succeeding generations, and the coronavirus pandemic
Authors: Glick Laurie , Romem Anat 
Published: February 2023

AbstractObjectiveTo examine the “sense of threat” and “sense of challenge” among Holocaust survivors and second‐ and third‐generation cohorts during the first coronavirus lockdown in Israel.BackgroundAging, especially among people who experienced trauma during their early years, as did Holocaust survivors, can be challenging when unusual circumstances, such as the coronavirus pandemic, coincide with it. Studies are inconclusive regarding the effect of transgenerational transmission of trauma of survivors to their offspring.Methods129 participants filled out a questionnaire based on Lazarus and Folkman's cognitive theory of psychological stress and coping. Data were collected through online questionnaires or phone interviews.ResultsAll generations reported “feeling this is a difficult situation.” Compared with the second generation, survivors reported a significantly higher “sense of threat” and significantly lower “sense of challenge.”DiscussionThis study found that all generations felt some degree of vulnerability, although their response overall was resilient.ImplicationsAwareness of the harmful effects of stressful life events on the vulnerable Holocaust survivors and their descendants has prompted the need to establish support systems that can be activated to assist them. Future research should also investigate whether these reactions were prevalent among Holocaust survivors and their descendants in other countries.
Distress tolerance, family cohesion and adaptability, and posttraumatic stress symptoms among combat veterans and their parents
Authors: Zerach Gadi , Gordon‐Shalev Tamar 
Published: February 2023

AbstractObjectiveThe aversive impact of combat‐related posttraumatic stress disorder (PTSD) on family members has been examined mainly among veterans' partners as well as veterans' offspring.BackgroundOnly a few studies have examined secondary PTSD symptoms (PTSS) in veterans' parents, and the conditions in which distress tolerance (DT) contributes to veterans' PTSS and parents' secondary PTSS (SPTSS) remain unexplored. In the present study, we aimed to use a dyadic approach to explore the association between veterans' and parents' DT and their PTSS and that of their parents, as well as to examine the moderating role of family cohesion and adaptability in these associations.MethodA volunteer sample of 102 dyads of Israeli combat veterans and their parents responded to online validated self‐report questionnaires in a cross‐sectional study. Analysis included actor–partner interdependence modeling (APIM) and moderation analyses.ResultsVeterans' PTSS was positively correlated with parents' SPTSS. Moreover, two actor effects were revealed wherein veterans' DT contributed to their own PTSS, and parents' DT negatively predicted their own SPTSS. Moreover, veterans' DT negatively predicted their parents' SPTSS (partner effect). Importantly, analysis of moderation revealed that under average and high levels of parental perception of family cohesion, higher levels of DT were tied to lower PTSS among veterans.ConclusionExposure to a traumatized veteran offspring might entail SPTSS among parents. Veterans' high DT is associated with lower PTSS, and their parents' perception of the family as cohesive might augment this association.ImplicationsThe findings highlight the importance of acknowledging distress of indirectly exposed parents of combat veterans. Strengthening military families' cohesion might be important for veterans coping with posttraumatic stress.