bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bleeding Complications in a Patient After the Unexpected Interaction
between Valproic Acid and Phenprocoumon
Authors: Wieringa André , Fiebrich Helle-Brit , Gelder Fleur van , Valkenburg Abraham J. , Maring Jan G. , Smolders Elise J. 
Published: March 2023

Background:
Phenprocoumon is a vitamin K antagonist that is widely prescribed in Europe
and Latin America for the prophylaxis and treatment of thromboembolic events.

Case Presentation:
A 90-year-old female was admitted to our hospital with tonic-clonic seizures,
possibly due to dementia syndrome.

:
Valproic acid (VPA) was prescribed for the treatment of seizures. VPA is an inhibitor of cytochrome
P450 (CYP) 2C9 enzymes. A pharmacokinetic interaction with phenprocoumon occurred,
which is a substrate for CYP2C9 enzymes. The interaction resulted in a strong INR increase and
subsequent clinically relevant bleeding in our patient.

:
Valproic acid is not specifically mentioned in the phenprocoumon drug label as a CYP2C9 inhibitor,
and in the Dutch medication surveillance database, no medication alert is shown when prescribing
this combination, and no interaction with phenprocoumon has been reported so far.

Conclusion:
When prescribing this combination, the prescriber should be warned and advised to
intensify INR monitoring if the combination is to be continued.
Anxiety, Depression, Body Mass Index, Physical Activity in Nomophobic
Italian Nurses: A Chronic Latent Inflammation?
Authors: Vitale Elsa , Mea Rocco , Benedetto Angelo , Capizzello Donatella , Zacchino Simone , Zaminga Melania , Russo Matteo , Ingrosso Filippo , Mazzarella Chiara , Maria Giovanni Scupola , Buccolieri Teresa , Lupo Roberto 
Published: March 2023

Aim:
To investigate which risk factors are strictly connected to nomophobia in Italian nurses, according to socio-demographic characteristics, Body Mass Index scores, physical activity habits, anxiety, and depression.

Methods:
An “ad hoc” online questionnaire has been created and then administered to Italian nurses. Data include sex, age, years of work experience, shift work per day, nursing educational level, Body Mass Index, physical activity, anxiety, depression, and nomophobia conditions. Univariate logistic regression has been performed to explore what potential factors may contribute to the nomophobia condition.

Results::
A total of 430 nurses agree to participate. No respondents recorded severe levels of nomophobia, as 308(71.6%) registered mild and 58(13.5%) registered moderate levels and 64(14.9%) reported no abnormal condition. Females seem to be more exposed than males to nomophobia (p<0.001); nurses aged from 31 to 40 years and also with less than 10 years of work experience are more affected compared to the other sub groups (p<0.001). Nurses who practice low physical activity reported significantly high levels of nomophobia (p<0.001) and nurses reporting high anxiety levels also suffer from nomophobia (p<0.001). The trend is inverse when considering depression condition since most of the nurses suffering from mild or moderate nomophobia levels reported the absence of depression condition (p<0.001). No statistical differences have been reported between nomophobia levels and shift work (p=0.269), nursing educational level (p=0.242), and BMI levels (p=0.183). Anxiety and physical activity report strong relationships with nomophobia condition (p<0.001).

Conclusion:
Nomophobia affects all individuals, especially young aged individuals. Although further studies on nurses will be implemented, including the workplace and training environments of nurses by allowing a clearer picture of the levels of “nomophobia” in general, as nomophobic behavior may have negative repercussions both in social and professional spheres.
REVOLUCIÓN 4.0
Authors: Salas Alvarez Daniel José 
Published: March 2023

Las revoluciones industriales han marcado en gran manera la evolución y transformación de la humanidad, llevando al hombre adaptarse a cambios, desde la primera revolución que inició con la invención de la máquina a vapor y su aplicación en la fabricación, industria y el transporte, llevando al inicio de la industrialización; la segunda casi doscientos años más tarde con la electricidad y su aplicaciónes a la industria ytransporte, mejorando así los procesos de producción, también se dio a nuevas innovaciones como el invento del automóvil y una gran variedad de electrodomésticos, iniciando lo que hoy se conoce como sociedad del consumo. La tercera revolución que dio grandes pasos en los avances tecnológicos con la invención de la computadoras, internet, llevando a la automatización industrial, convirtiendo la tecnología en recurso clave para la economía y conocimiento.
Evaluación Del Riesgo Ambiental En Campus Universitarios. Caso Estudio: Universidad De Córdoba-Colombia
Authors: Mejia Avila Doris , Ortega Agámez Kelly , Martínez Gómez Julieth 
Published: March 2023

La presente investigación evaluó los factores de riesgo ambiental en los laboratorios de la Facultad de Ciencias Básicas de la Universidad de Córdoba en Colombia. Mediante el ajuste y la aplicación de herramientas conceptuales y metodológicas como la Guía Institucional de Gestión Ambiental para la Identificación y Evaluación del Riesgo Ambiental de la Universidad Pedagógica Nacional, la norma española UNE 150008 de análisis y evaluación de riesgo ambiental y la norma colombiana GTC 104 sobre gestión de riesgo ambiental se identificaron y valoraron los escenarios de riesgo ambiental en 18 laboratorios de la Universidad y se plantearon las acciones de manejo y prevención.
El grado de riesgo se estimó para tres entornos: natural, humano y socioeconómico, estimando la probabilidad de ocurrencia y la gravedad de las consecuencias para los escenarios de cada entorno. Se encontró que para los tres entornos, los escenarios con mayor riesgo ambiental son el Vertimiento de residuos líquidos químicos, la Volatilización de Sustancias Químicas y el Escape de gases y/o vapores contaminantes, cuyo grado de complejidad del riesgo ambiental oscila entre Leve, Moderado y Medio. No obstante, una predominancia del Riesgo Ambiental Moderado. El grado de riesgo ambiental Medio en los laboratorios evaluados solo se presentó en el entorno Humano.
A partir de los escenarios de riesgo evaluados se identificaron acciones de manejo que permitirán mitigarlos, controlarlos o prevenirlos tales como: caracterización de vertimientos; la renovación y mantenimiento periódico de las cámaras extractoras; capacitación a los usuarios acerca de la importancia del uso de los implementos de seguridad y adopción de medidas de control que induzcan el uso de estos elementos.
An Assessment of Perspectives and Concerns Among Research Participants of Childbearing Age Regarding the Health-Relatedness of Data, Online Data Privacy, and Donating Data to Researchers: Survey Study
Authors: Hendricks-Sturrup Rachele , Lu Christine Y 
Published: March 2023

Background
The June 2022 US Supreme Court decision to ban abortion care in Dobbs v Jackson Women’s Health Organization sparked ominous debate about the privacy and safety of women and families of childbearing age with digital footprints who actively engage in family planning, including abortion and miscarriage care.

Objective
To assess the perspectives of a subpopulation of research participants of childbearing age regarding the health-relatedness of their digital data, their concerns about the use and sharing of personal data online, and their concerns about donating data from various sources to researchers today or in the future.

Methods
An 18-item electronic survey was developed using Qualtrics and administered to adults (aged ≥18 years) registered in the ResearchMatch database in April 2021. Individuals were invited to participate in the survey regardless of health status, race, gender, or any other mutable or immutable characteristics. Descriptive statistical analyses were conducted using Microsoft Excel and manual queries (single layer, bottom-up topic modeling) and used to categorize illuminating quotes from free-text survey responses.

Results
A total of 470 participants initiated the survey and 402 completed and submitted the survey (for an 86% completion rate). Nearly half the participants (189/402, 47%) self-reported to be persons of childbearing age (18 to 50 years). Most participants of childbearing age agreed or strongly agreed that social media data, email data, text message data, Google search history data, online purchase history data, electronic medical record data, fitness tracker and wearable data, credit card statement data, and genetic data are health-related. Most participants disagreed or strongly disagreed that music streaming data, Yelp review and rating data, ride-sharing history data, tax records and other income history data, voting history data, and geolocation data are health-related. Most (164/189, 87%) participants were concerned about fraud or abuse based on their personal information, online companies and websites sharing information with other parties without consent, and online companies and websites using information for purposes that are not explicitly stated in their privacy policies. Free-text survey responses showed that participants were concerned about data use beyond scope of consent; exclusion from health care and insurance; government and corporate mistrust; and data confidentiality, security, and discretion.

Conclusions
Our findings in light of Dobbs and other related events indicate there are opportunities to educate research participants about the health-relatedness of their digital data. Developing strategies and best privacy practices for discretion regarding digital-footprint data related to family planning should be a priority for companies, researchers, families, and other stakeholders.
The Priorities of End Users of Emergency Department Electronic Health Records: Modified Delphi Study
Authors: Yip Matthew , Ackery Alun , Jamieson Trevor , Mehta Shaun 
Published: March 2023

Background
The needs of the emergency department (ED) pose unique challenges to modern electronic health record (EHR) systems. A diverse case load of high-acuity, high-complexity presentations, and ambulatory patients, all requiring multiple transitions of care, creates a rich environment through which to critically examine EHRs.

Objective
This investigation aims to capture and analyze the perspective of end users of EHR about the strengths, limitations, and future priorities for EHR in the setting of the ED.

Methods
In the first phase of this investigation, a literature search was conducted to identify 5 key usage categories of ED EHRs. Using key usage categories in the first phase, a modified Delphi study was conducted with a group of 12 panelists with expertise in both emergency medicine and health informatics. Across 3 rounds of surveys, panelists generated and refined a list of strengths, limitations, and key priorities.

Results
The findings from this investigation highlighted the preference of panelists for features maximizing functionality of basic clinical features relative to features of disruptive innovation.

Conclusions
By capturing the perspectives of end users in the ED, this investigation highlights areas for the improvement or development of future EHRs in acute care settings.
“Los entramados del libro político: superventas, edición y cultura”. ¿Cómo se fabrica un best seller político? La trastienda de los éxitos editoriales y su capacidad de intervenir en la agenda pública
Authors: Hurtado-Tarazona Alejandra 
Published: March 2023

Reseña de:¿Cómo se fabrica un best seller político? La trastienda de los éxitos editoriales y su capacidad de intervenir en la agenda pública. Ezequiel Saferstein. Buenos Aires: Siglo XXI Editores, 2021, 220 pp. ISBN: 978-987-801-096-0.
Censo sectorial de identificación de unidades productivas de dulces en Ocaña y la región, tipificación y caracterización de los dulces
Authors: Urbina Patiño Carlos Mauricio 
Published: March 2023

El censo sectorial de identificación de unidades productivas de dulces permitió identificar a la gran mayoría de los productores de dulces de Ocaña y la región, que actualmente se dedican a esta actividad. Por medio del cual se pudo hallar la tipología de los productos que desarrollan en la región y las características de las empresas y las personas naturales que se dedican a esta actividad.
Los hallazgos encontrados en esta investigación permitieron determinar cuáles son las características básicas en el proceso de producción, las condiciones legales del sector, la estandarización del producto, el tipo de materia primera para la realización y las características demográficas de las empresas y personas naturales vinculadas a la producción de dulces en Ocaña y la región.
La mayoría de los productores de dulces actualmente no se encuentran legalmente constituidos y al ser productos alimenticios se encuentran restringidos a la normativa legal direccionada por el Instituto Nacional de Vigilancia de Medicamentos y Alimentos (INVIMA). Esto dificulta que los productos se puedan comerciar en diferentes espacios, pues al no contar con el registro INVIMA el producto no puede ser vendido de forma legal.
Alrededor del sector se presentan varias problemáticas, sin embargo, algunos casos especiales han permitido determinar que estructurando mejor el proceso de producción y capacitándose en normativa legal y en procesos de producción que permitan reglamentar legalmente la producción de este tipo de alimentos, los productores podrían empezar a introducir sus dulces en nuevos mercados, de forma rentable.
Caña panelera como potencializador de la economía en Convención
Authors: Dulcey Nieves Juan Pablo , CORONEL MONTAGUTH YESSY LORENA 
Published: March 2023

Este artículo científico presenta las unidades de análisis resultantes que permitió la Construcción del Perfil Productivo del Municipio de Convención. Dejando estructurado estrategias que impliquen oportunidades en el mercado laboral y cimiente rutas de inclusión a población víctima, desplazamiento y extrema pobreza al desarrollo económico y actividad laboral.
La investigación logró revelar la producción e panela como una actividad que si se direcciona de la forma correcta logrará un desararrollo socioeconómico del municipio. Esto debido a las características históricas del cultivo, el cual ha hecho presencia desde principios del siglo XX, además, el momento de apertura económica ha permitido que se abran nuevos mercados que deben ser aprovechados por os productores de panela.
Sin embargo, en la actualidad la certificación que emite el INVIMA (Resolución 779 del 2006), solo es cumplida por menos del 5,0% de los trapiches en el municipio lo cual no permite aprovechar la coyuntura económica, dado que el mercado extranjero es exigente en materia de calidad y procesos productivos de los artículos comprados.
Asi mismo, la investigación está ajustada en el marco del proceso de posconflicto que está viviendo Colombia, dado que el desarrollo productivo en el marco de la legalidad, permitirá que los habitantes abandonen los cultivos ilícitos, el cual es utilizado como alternativa de generación de ingresos.
Prácticas empresariales en la actividad marmolera en el Huila
Authors: Andrade Navia Juan Manuel 
Published: March 2023

La evolución de actividades económicas, impulsadas por agentes empresariales, se constituye en objeto de estudio para comprender en toda su expresión, la realidad actual de las regiones. Es en esta lógica que el presente estudio procura identificar y comprender las características del origen de la actividad marmolera en el departamento del Huila y las prácticas sus agentes empresariales.
En consecuencia, para efectos de una mejor comprensión se clasificó la actividad en dos niveles de gestión; la actividad extractiva y la actividad transformadora, salvo algunos casos donde se presentan las dos formas bajo el mando de un mismo agente.
Igualmente, se puede deducir que la experiencia acumulada por parte de los agentes, desempeña un papel determinante para la concreción de iniciativas empresariales en la actividad.
De otra parte, se aprecia que durante las décadas de 1950 y 1960, el Estado estimuló la actividad mediante la financiación de estudios que permitiesen determinar las potencialidades del recurso mineral. Sin embargo, su rol a partir de 1990 se limitó a labores de control a la minería de hecho o tradicional, con pocos esfuerzos para su desarrollo. En este sentido, se destacan pequeños apoyos, sobretodo, por entidad como el Sena y las Alcaldías.
Biomarker Changes Associated With Both Dulaglutide and Cardiovascular Events in the REWIND Randomized Controlled Trial: A Nested Case-Control Post Hoc Analysis
Authors: Gerstein Hertzel C. , Lee Shun-Fu , Paré Guillaume , Bethel M. Angelyn , Colhoun Helen M. , Hoover Anastasia , Lakshmanan Mark , Lin Yanzhu , Pirro Valentina , Qian Hui-Rong , Ruotolo Giacomo , Ryden Lars , Wilson Jonathan M. , Duffin Kevin L. 
Published: March 2023

OBJECTIVE
The glucagon-like peptide-1 receptor agonist dulaglutide reduced MACE in the Researching Cardiovascular Events with a Weekly Incretin in Diabetes (REWIND) trial. This article expores the relationship of selected biomarkers to both dulaglutide and major adverse cardiovascular events (MACE).

RESEARCH DESIGN AND METHODS
In this post hoc analysis, stored fasting baseline and 2-year plasma samples from 824 REWIND participants with MACE during follow-up and 845 matched non-MACE participants were analyzed for 2-year changes in 19 protein biomarkers. Two-year changes in 135 metabolites were also analyzed in 600 participants with MACE during follow-up and in 601 matched non-MACE participants. Linear and logistic regression models were used to identify proteins that were associated with both dulaglutide treatment and MACE. Similar models were used to identify metabolites that were associated with both dulaglutide treatment and MACE.

RESULTS
Compared with placebo, dulaglutide was associated with a greater reduction or lesser 2-year rise from baseline in N-terminal prohormone of brain natriuretic peptide (NT-proBNP), growth differentiation factor 15 (GDF-15), high-sensitivity C-reactive protein, and a greater 2-year rise in C-peptide. Compared with placebo, dulaglutide was also associated with a greater fall from baseline in 2-hydroxybutyric acid and a greater rise in threonine (P &lt; 0.001). Increases from baseline in two of the proteins (but neither metabolite) were associated with MACE, including NT-proBNP (OR 1.267; 95% CI 1.119, 1.435; P &lt; 0.001) and GDF-15 (OR 1.937; 95% CI 1.424, 2.634; P &lt; 0.001).

CONCLUSIONS
Dulaglutide was associated with a reduced 2-year rise from baseline of NT-proBNP and GDF-15. Higher rises of these biomarkers were also associated with MACE.
PECULIARITIES OF SOOT DEPOSITION, TEARING OF CLOTHING AND HUMAN BODY SIMULATOR DURING SHOOTINGS FROM «FORT 12R» AND «AE 790G1» PISTOLS
Authors: Kuslii Yuri Yuriі , Shevchuk Yurii , Fomin Oleksandr , Adamchuk Oksana , Konopelniuk Oleksandr 
Published: March 2023

The study of macroscopic features of the clothing damage or the damage to the human body, the presence of additional factors of a shot on it – is one of the basic methods of analysis used in medical forensics. The appearance of new types of firearms requires the appropriate conduct of experimental research in order to update the theoretical database of experts.
The purpose of the work to investigate the features of soot deposition, tearing of clothing and a human body simulator when using «FORT 12R» and «AE 790G1» pistols.
Material and methods. For the study, 120 gelatin blocks were used, which later remained bare or were covered with one of the fabrics: cotton, denim or leatherette. After that, shots were fired from close range, 25 and 50 cm using «FORT 12R» and «AE 790G1» pistols, with subsequent analysis of macroscopic soot deposition around the entrance firing hole and the number of ruptures in clothing or a human body simulator, if the shot was fired at a bare block.
Results. When analyzing soot deposition, it was reliably established (p<0.0070) or a tendency (p=0.0763, only for leatherette) towards its macroscopic detection when shots were fired at close range in all studied groups of bare blocks and blocks covered with clothing when shots were fired from a distance of 25 cm and the absence of the soot when fired from a distance of 50 cm when fired from both pistols. When comparing the data on the number of ruptures between the «Fort 12R» and «AE 790G1» pistols, reliably (p<0.01-0.05) higher values were found when firing with the «AE 790G1» from a close distance into blocks covered with cotton and denim fabric, when shot from 25 cm into the blocks covered with cotton fabric and a slight tendency (p=0.095) to higher values when shot with the «AE 790G1» from a close distance into the blocks covered with leatherette.
Conclusions. When using the «FORT 12R» and «AE 790G1» pistols, practically no differences in soot deposition was found, however, when analyzing the number of ruptures in clothing and the human body simulator, higher values were found when using the «AE 790G1» pistol.
CHARACTERISTICS OF INJURIES TO DRIVERS AND PASSENGERS IN THE CABIN OF B-CLASS CARS IN AN ANGLE COLLISION
Authors: Zozulia Vitalii 
Published: March 2023

The article presents the features of damage to the driver and passenger in the cabin of a B-class car during an angle collision.
The cases of road accidents from 2008 to 2021 in the Zhytomyr, Rivne, and Volyn regions of Ukraine were analyzed. Cases of angle (right and left) collisions with fatal consequences for the driver and the passenger in the front seat of B-class cars were considered in automobile trauma. General scientific and special methods were used: system-structural analysis, observation, comparison, description. In addition, a forensic examination of the injuries was carried out. Statistical analysis included primary processing of data by methods of descriptive statistics and testing of the null hypothesis by the method of multifactorial analysis.
The results. A frequency analysis of received injuries was carried out. In the case of a left side collision in the passenger compartment of a B-class car, the drivers suffered injuries to the front of the body, often injuries to the soft tissues of the left leg. It is noteworthy that the soft tissues of the right hand were not injured in the left side collision. Passengers of B-class cars had frontal torso injuries in the case of a left angle collision, as did the drivers. Also common patterns were the absence of damage to the body from behind, rupture of the symphysis, and pelvic fractures on both sides.
Conclusion. In the case of fatal injury in the cabin of B-class cars in the case of a right-side collision, the drivers had numerous injuries to the back and front of the body. The injuries in the car interior differed in the presence of soft tissue damage to all four limbs, but bone fractures of both the upper and lower limbs were localized exclusively on the right. As with the left and right lateral impact, there was no fracture of the pelvic bones on both the left and the right side with preservation of the integrity of the pubic symphysis.
For drivers with fatal injuries in the cabin of B-class cars in the case of a right-side collision, multiple injuries of the thoracic and abdominal organs and the retroperitoneal space were observed: injuries to the right and left kidneys, lacerations of the liver, lacerations of the right and left lungs.