bluuebunny/crossref_metadata_2025_split huggingface dataset:
Life events sometimes alter the trajectory of personality development: Effect sizes for 25 life events estimated using a large, frequently assessed sample
Authors: Dugan Keely A. , Vogt Randi L. , Zheng Anqing , Gillath Omri , Deboeck Pascal R. , Fraley R. Chris , Briley D. A. 
Published: April 2023

AbstractObjectivePersonality changes across the life span. Life events, such as marriage, becoming a parent, and retirement, have been proposed as facilitating personality growth via the adoption of novel social roles. However, empirical evidence linking life events with personality development is sparse. Most studies have relied on few assessments separated by long time intervals and have focused on a single life event. In contrast, the content of life is composed of small, recurrent experiences (e.g., getting sick or practicing a hobby), with relatively few major events (e.g., childbirth). Small, frequently experienced life events may play an important and overlooked role in personality development.MethodThe present study examined the extent to which 25 major and minor life events alter the trajectory of personality development in a large, frequently assessed sample (Nsample = 4904, Nassessments = 47,814, median retest interval = 35 days).ResultsUsing a flexible analytic strategy to accommodate the repeated occurrence of life events, we found that the trajectory of personality development shifted in response to a single occurrence of some major life events (e.g., divorce), and recurrent, “minor” life experiences (e.g., one's partner doing something special).ConclusionBoth stark role changes and frequently reinforced minor experiences can lead to personality change.
Deep learning improves prediction of periodontal therapy effectiveness in Chinese patients
Authors: Wang Ruiyang , Wang Ruixin , Yang Tong , Jiao Jian , Cao Zhanqiang , Meng Huanxin , Shi Dong 
Published: April 2023

AbstractThe objectiveThis study aims to propose a new model to predict the specific treatment effectiveness at site level by analyzing massive amounts of periodontal clinical data with deep learning methods.The background data discussing the present status of the fieldIn light of the low accuracy of current tools, the proposed models cannot fully meet the needs of clinical effectiveness prediction and cannot be applied to on site level prognosis development and formulation of specific treatment plan.Materials and MethodsPeriodontal examination data of 9273 Chinese patients were extracted and used to propose a Sequence‐to‐Sequence model after performing data management and reconstruction. The model was optimized by introducing the Attention mechanism.ResultsIn the test set, the model obtained an average site‐level probing depth (PD) accuracy (defined as the proportion of sites with <1 mm deviation of the predicted result from the true value) of 92.4% and high sensitivity (98.6%) for the pocket closure variable. For sites with baseline PD <5 mm, the model achieved a prediction accuracy of 94.6%, while it decreased to 79.9% at sites with PD ≥5 mm. In contrast, for teeth with initial mean PD ≥5 mm, the prediction accuracy significantly differed between molars and non‐molars.ConclusionOur model is the first to predict the site‐level effectiveness with high accuracy and sensitivity. Future prediction models should incorporate deep learning for improved clinical prediction.
Biomarker panel discriminates diabetics with and without periodontitis pre‐ and post‐therapy
Authors: Miller Craig S. , Ding Xiuhua , Nagarajan Radha , Dawson Dolph R. , Ebersole Jeffrey L. 
Published: April 2023

AbstractBackground and ObjectiveBiological regulators of periodontal inflammation, collagen degradation, and insulin resistance have not been determined in association with severity of periodontitis and response to periodontal treatment in diabetics. Our objective was to determine whether type 2 diabetes (T2DM) patients with periodontal disease present a distinct salivary biomarker profile compared with T2DM patients without periodontal disease and healthy subjects (without diabetes and periodontitis) pre‐ and post‐nonsurgical therapy.MethodsClinical parameters of periodontal health and whole unstimulated saliva were collected from 92 participants (31 Not Periodontitis, NP; 32 T2DM without periodontitis, DWoP; and 29 with T2DM with periodontitis, DWP) at baseline. The T2DM groups received scaling and root planning (SRP) and provided saliva at 6‐week follow‐up. Salivary concentrations of interleukin (IL)‐1β, IL‐6, matrix metalloproteinase‐8 (MMP‐8), and resistin were measured by immunoassay.ResultsThe DWP group had significantly more disease and higher salivary concentrations at baseline for IL‐1β, MMP‐8, and resistin (p's < .01) compared with DWoP and NP. SRP resulted in significant improvement in periodontal parameters for the T2DM groups; however, more disease persisted (p < .001), and IL‐1β, MMP‐8, and resistin concentrations remained significantly higher in the DWP than the DWoP group (p < .01) at 6 weeks post‐treatment. Principal component analysis demonstrated the DWoP group appeared more biologically similar to the NP group than the DWP group. Concentrations of these salivary biomarkers increased with increasing periodontal disease severity (p < .05) in this study population.ConclusionSalivary concentrations of IL‐1β, MMP‐8, and resistin appear to serve as biomarkers of periodontal status pre‐ and post‐treatment, irrespective of diabetes status.
Low risk of viral hepatitis amongst patients with severe mental disorders
Authors: Fernández Tábatha , Plana Teresa , Tardón Laia , Marco Oriol , Navarro Lourdes , Bartrés Concepció , Colom Joan , Goikolea José Manuel , Cavero Myriam , Pacchiarotti Isabella , Lens Sabela , Forns Xavier , Martín‐Santos Rocío , Mariño Zoe 
Published: April 2023

AbstractBackground and AimsPatients with severe mental disorders (SMD) have been classically considered as a particularly high‐risk population for bloodborne virus infections. We performed a systematic screening of hepatitis B and C virus among the population with SMD in the area of influence of Hospital Clínic (Barcelona) in order to evaluate the real prevalence of these infections and achieve HCV microelimination in this subpopulation.MethodsWe screened two cohorts for anti‐HCV and HBsAg: Cohort A (hospitalized patients with SMD, done systematically) and Cohort B (outpatients, mental health centre‐CSMA, done voluntarily). Risk factors and socio‐demographic variables were collected. In positive cases, telematic review was activated by Hepatology, calculation of FIB‐4 and prescription of direct‐acting agents (DAA) in HCV or follow‐up in HBV.ResultsIn Cohort A, 404 patients were screened. 3 HBV patients were detected (0.7%). In all of them, there was a history of drug use. 12 anti‐HCV positive patients were detected (3%); 8 of them had a history of drug use. Among the HCV positive, only 2 patients were viraemic (received DAA, both achieving SVR) as most of them (n = 6) had already been cured with DAA. In cohort B, 305 patients were screened, after 542 (64% of the target population) declined to participate. No cases of HCV or HBV were detected.ConclusionsHCV/HBV prevalence among SMD population with no history of drug use does not seem to be different from the general population. These data may be of interest for defining health policies.
The Santa Filomena meteorite shower: Trajectory, classification, and opaque phases as indicators of metamorphic conditions
Authors: Tosi Amanda , Zucolotto Maria Elizabeth , Andrade Diana Paula , Winter Othon Cabo , Mourão Daniela Cardozo , Sfair Rafael , Ziegler Karen , Perez Pablo Daniel , Suarez Sergio , Ornellas Iara Deniz , Zurita Marcelo , Mendes Julio Cezar , Kellner Alexander Wilhelm , Wolff Wania 
Published: April 2023

AbstractOn August 19, 2020, at 13:18—UTC, a meteor event ended as a meteorite shower in Santa Filomena, a city in the Pernambuco State, northeast Brazil. The heliocentric orbital parameters resulting from images by cameras of the weather broadcasting system were semimajor axis a = 2.1 ± 0.1 au, eccentricity e = 0.55 ± 0.03, and inclination i = 0.15o ± 0.05. The data identified the body as an Apollo object, an Earth‐crossing object with a pericenter interior to the Earth's orbit. The chemical, mineralogical, and petrological evaluations, as well as the physical analysis, followed several traditional techniques. The meteorite was identified as a H5‐6 S4 W0 ordinary chondrite genomict breccia. The large amount of metal in the meteorite made a metallographic evaluation based on the opaque phases possible. The monocrystalline kamacite crystals suggest a higher petrological type and the distorted Neumann lines imply at least two different shock events. The absence of the plessite phase shows that the meteorite did not reach the highest shock levels S5 and S6. The well‐defined polycrystalline taenite is indicative of petrologic types 4 and 5 due to the conserved internal tetrataenite rim at the boundaries. The presence of polycrystalline taenites and the characteristics of the Agrell Effect suggest that the Santa Filomena meteorite did not reheat above 700°C. The absence of martensite confirms reheating temperatures <800°C and a slow cooling rate. The Ni contents and sizes of the zoned taenite particles indicate a slow cooling rate ranging from 1 to 10 K Myr−1.
Kalecki meets Schumpeter: The decline of competition in a demand‐led dynamic model
Authors: Bottega Ana , Ribeiro Rafael S. M. 
Published: April 2023

AbstractThis paper contributes to the post‐Keynesian literature by building a macrodynamic Kaleckian model that incorporates recent evidence on market concentration and its relationship with capital accumulation and income distribution using Schumpeterian insights. This is done in two steps. First, we model a two‐dimensional system that sets the dynamics between the wage share and the capital‐effective labor supply ratio. Then, we extend the model, in the second step, to a three‐dimensional system that incorporates the state‐transition function of concentration. Our model suggests that higher market concentration may be associated with a permanent decline in employment, capacity utilization, wage share, and capital accumulation.
Phenotypic plasticity: The role of a phosphatase family Rap in the genetic regulation ofBacilli
Authors: Gallegos‐Monterrosa Ramses , Kovács Ákos T. 
Published: April 2023

AbstractIn the last two decades, an increasing number of bacterial species have been recognized that are able to generate a phenotypically diverse population that shares an identical genotype. This ability is dependent on a complex genetic regulatory network that includes cellular and environmental signals, as well as stochastic elements. AmongBacilli, a broadly distributed family of Rap (Response‐regulatoraspartylphosphate) phosphatases is known to modulate the function of the main phenotypic heterogeneity regulators by controlling their phosphorylation. Even more, their related extracellular Phr (Phosphataseregulator) peptides function as signals, creating a cell–cell communication network that regulates the phenotypic development of the entire population. In this review, we examine the role that the Rap phosphatases and their Phr peptides play in the regulation ofBacillus subtilisphenotypic differentiation, and in other members of theBacillusgenus. We also highlight the contribution of these regulatory elements to the fitness of bacterial cells and mobile genetic elements, for example, prophages and conjugative vectors.
Blood crossmatching patterns in a population of killer whales (Orcinus orca) in managed care
Authors: Nollens Hendrik H. , Teman Sarah J. , Burgess Rebecca L. , St. Leger Judy A. , Schmitt Todd L. 
Published: April 2023

AbstractBlood crossmatching is necessary to determine transfusion compatibility between individuals, especially for species for which blood groups have not yet been defined, such as the killer whale (Orcinus orca). This study evaluated methodology for crossmatching in killer whales from a managed care population using individuals of known lineages. Twenty killer whales were evaluated for major or minor crossmatch incompatibilities, determined by evidence of macro‐agglutination. Crossmatching incompatibilities were rarely observed, both when considering 1+ reactions as incompatibilities (~15%; 59/400 pairings with 1+ to 4+) and when omitting 1+ reactions (6%; 24/400 pairings with 2+ to 4+). A universal red blood cell donor within this population (whale T) and universal recipients of red blood cells within this population (whales E, M, O, P, R, S) were identified. Relationships were examined between the most common major crossmatch phenotypes and maternal or paternal lineages. Since these whales have not been previously transfused, the diversity of crossmatch reactions could indicate the presence and diversity of preexisting alloantibodies in killer whale plasma. This study highlights the clinical value of applying a personalized medicine approach to a managed care population.
Ailments of the Soul
Authors: Beran Ondřej 
Published: April 2023

AbstractThe paper aims to trace the distinctive character of the talk of the soul and to disentangle it from the talk of the mind. The key context will be the way in which we talk about souls that are ailing. As a point of departure, I use the later Wittgenstein's notion of the soul as anti‐dualist and anti‐substantive, which brings it close to Dennett's or Davidson's philosophy of mind, but which Wittgensteinian ethicists have elaborated upon as concerned with matters of good and evil, and beauty. In relation to these concerns, the sense of the ailing soul is different from issues relating to mental health. I then discuss cases of ailments of the soul that would be misleading to analyse as matters of mental health (issues): addiction, racism, and environmental grief. I conclude with a plea for maintaining the talk of the soul as helpful for making sense of existential or beauty‐ or morality‐related ailments, yet as something that does not necessarily subscribe to any doctrine of the soul as a substance. In support, I also use arguments from the spheres of eco‐theology and public theology.
Clinical and genetic characterization of Netherton syndrome due to SPINK5 founder variant in Latvian population
Authors: Nartisa Inga , Kirsteina Rasa , Neiburga Katrina Daila , Zigure Sanita , Ozola Lota , Grantina Ineta , Micule Ieva , Murmane Daiga , Slisere Baiba , Gailite Linda , Vilne Baiba , Rots Dmitrijs , Taurina Gita , Kurjane Natalja 
Published: April 2023

AbstractObjectiveNetherton syndrome (NS) (OMIM:256500) is a very rare autosomal recessive multisystem disorder mostly affecting ectodermal derivatives (skin and hair) and immune system. It is caused by biallelic loss‐of‐function variants in the SPINK5 gene, encoding the protease inhibitor lymphoepithelial Kazal‐type‐related inhibitor (LEKTI).Material, Methods and ResultsHere, we describe NS clinical and genetic features of homogenous patient group: 9 individuals from 7 families with similar ethnic background and who have the same SPINK5 variant (NM_006846.4: c.1048C > T, p.(Arg350*)) in homozygous or compound heterozygous states, suggesting that it is a common founder variant in Latvian population. Indeed, we were able to show that the variant is common in general Latvian population, and it shares the same haplotype among the NS individual. It is estimated that the variant arose >1000 years ago. Clinically, all nine patients exhibited typical NS skin changes (scaly erythroderma, ichthyosis linearis circumflexa, itchy skin), except for one patient who has a different skin manifestation—epidermodysplasia. Additionally, we show that developmental delay, previously underrecognized in NS, is a common feature among these patients.ConclusionsThis study shows that the phenotype of NS individuals with the same genotype is highly homogeneous.
Implementation of nursing services in community corrections: A community‐academic partnership
Authors: Johnson Amy , Reising Virginia , Cruz Cindy , Franklin Charisse , Martin Andre 
Published: April 2023

AbstractPersons who are incarcerated (PWAI) suffer from a disproportionately higher number of physical and mental health conditions. While most jails and prisons provide onsite healthcare, community correctional centers often do not and accessing community healthcare is challenging due to insurance issues, inadequate health literacy, mistrust, and long waits for appointments.A registered nurse‐led wellness clinic provides a viable solution to addressing the healthcare needs of PWAI in a community correctional setting. Through a community‐academic partnership between a college of nursing and two community correctional transitional centers for men, a registered nurse (RN) faculty member and nursing students provide onsite healthcare. Services include, but are not limited to, acute and chronic disease management, case management, healthcare navigation, and health education.In the first 2 years of operation, there have been 587 new resident health assessments, 882 RN visits, and 152 group education sessions. RN visits have been primarily for: connection to resources (42.6%), medication management (15.6%), and acute conditions (12%).A RN‐led wellness clinic is an innovative way to address health needs for PWAI. While this model of care focuses on an academic RN faculty practice at community correctional centers it could be replicated across community settings.
The effects of tokenization on ride‐hailing blockchain platforms
Authors: Sun Luoyi , Hua Guowei , Teunter Ruud H. , Cheng T.C.E. , Shen Zuo‐Jun Max 
Published: April 2023

AbstractThe rapid development of blockchain has inspired many traditional centralized intermediaries to transform their transaction models, especially for the peer‐to‐peer market. Lately, the token‐based (blockchain) system (with cryptocurrency) is gaining popularity. However, little is known about the (comparative) performance of different operating types. In this study, we build an analytical framework to find the optimal strategies for the token‐based and nontoken‐based blockchain (as a special application scenario) platforms and derive the essential model properties and characteristics. We analytically show how the optimal mining bonus depends on the fraction of reserved tokens sold to customers and on the price‐to‐sales ratio. Furthermore, we obtain several actionable findings for choosing suitable platform types under different scenarios. The shift from the nontoken‐based platform to the token‐based platform may yield greater social welfare unless the nontoken‐based system operates with a much larger ride price, which we show to be unrealistic for the considered Beijing case through numerical studies. Moreover, we find that the matching probability for the token‐based platform is predominantly higher than that for the nontoken‐based one. Besides, government interventions may encourage a path toward a fair consensus mechanism or a high decentralization level in order to enhance social welfare. One unanticipated finding is that a higher decentralization level may lead to a lower mining capacity shortage and so to a more efficient system, indicating that the combination of blockchain and the sharing economy has much potential.
Transcriptome and metabolites analysis of water‐stressed grape berries at different growth stages
Authors: Ma Weifeng , Lu Shixiong , Li Wenfang , Nai Guojie , Ma Zonghuan , Li Yanmei , Chen Baihong , Mao Juan 
Published: April 2023

AbstractDrought is one of the main abiotic factors affecting grape quality. However, the impacts of drought stress on sugar and related gene expression during grape berry ripening remain unclear. In this experiment, the grapes were subjected to different levels of continuous water stress from 45 to 120 days after flowering (DAA) to study the changes in berry sugar content and the expression of genes related to sugar metabolism under different water stresses. Data supported that glucose, fructose, sucrose, and soluble sugars increased from 45 DAA. Combined with previous research results, T1, T2, and Ct grape berries with 60 ~ 75 DAA and large differences in sucrose, fructose, glucose and soluble sugars compared with the Ct were selected for RNA sequencing (RNA‐seq). Through transcriptome analysis, 4471 differentially expressed genes (DEGs) were screened, and 65 genes in photosynthesis, ABA signaling pathway and photosynthetic carbon metabolism pathway were analyzed further by qRT‐PCR. At 60 DAA, the relative expression levels of CAB1R, PsbP, SNRK2, and PYL9 were significantly upregulated in response to water stress, while AHK1, At4g02290 were down‐regulated. At 75 DAA, the relative expression levels of ELIP1, GoLS2, At4g02290, Chi5, SAPK, MAPKKK17, NHL6, KINB2, and AHK1 were upregulated. And CAB1R, PsbA, GoLS1, SnRK2, PYL9, and KINGL were significantly downregulated under moderate water stress. In addition, PsbA expression was down‐regulated in response to water stress. These results will help us to fully understand the potential connections between glucose metabolism and gene expression in grapes under drought stress.
Peripheral odontogenic fibroma in a child with Ellis‐van Creveld syndrome: Case report
Authors: Ferraresso Lucas Fernando Oliveira Tomáz , Fagundes Fábio Anevan Ubiski , Padovese Mariella , Singi Paola , Paiva Mayra Frasson , Inagaki‐Nomura Luciana Tiemi , Dezan‐Garbelini Cássia Cilene , Boer Farli Aparecida Carrilho 
Published: April 2023

AbstractIntroductionEllis‐van Creveld (EVC) syndrome is an autosomal recessive disorder predominantly characterized by a disproportionate dwarfism, ectodermal dysplasia, postaxial polydactyly, and congenital heart malformations and pulmonary hypoplasia.ObjectiveIn this article, we hereby present a case of a 6‐year‐old Brazilian boy with EVC syndrome who presented a rare oral lesion as well as a remarkable number of classical and uncommon oral and dental features.Case ReportClinical and radiographic examination revealed multiple enamel hypoplasia, teeth agenesis, conical teeth, lower canine rotation, bilateral posterior crossbite, taurodontism of deciduous and permanent molars and delayed tooth eruption, dental caries, and absent vestibular sulcus. Additionally, a whitish lobulated nodule located in the alveolar ridge in the anterior region of the mandible was noted. Anatomopathological examination was compatible with the diagnosis of peripheral odontogenic fibroma (POF). In a 10‐month clinical follow‐up, no signs of recurrence were observed.ConclusionIn view of the characteristic oral findings of EVC syndrome and the potential for recurrence of POF, the pediatric dentist plays an essential role in clinical follow‐up, planning and preventive, and rehabilitative treatment.