bluuebunny/crossref_metadata_2025_split huggingface dataset:
A novel 3D non-degenerate hyperchaotic map with ultra-wide parameter rang and coexisting attractors periodic switching
Authors: Huang Lilian , Li Chuang , Liu Jin , Zhong Yu , Zhang Hao 
Published: May 2023

Abstract
With the maximum number of positive Lyapunov exponents, the non-degenerate hyperchaotic systems typically have more complex dynamics and better anti-degradation properties than general chaotic systems. By introducing trigonometric functions, this paper proposes a three-dimensional(3D) hyperchaotic map with a concise symmetric structure. From the perspective of the Lyapunov exponent, it is proved mathematically that the new map can always maintain the chaotic state in an infinitely wide parameter range. Numerical simulations further show that the map has rich dynamic behaviors, such as antimonotonicity, transient chaos, and coexisting symmetric attractors. In particular, periodic switching of symmetric attractors can be achieved by changing the initial value, which is rarely seen in other chaotic maps. Furthermore, combined with an offset constant, the polarity transformation of the attractors in a single direction has been realized successfully. Finally, the performance analysis indicates that the sequence generated by the new map has extremely higher complexity and pseudo-randomness, and the physical realizability of the map is also verified by the results of the DSP hardware experiment.
Elastic porous microspheres combined with extracellular matrix hydrogel as injectable composites for the dual-release of bioactive factors to promote tissue regeneration
Authors: Zhu Meifeng , Li Yi , Kong Deling , Liu Siyang , Li Wen , Zhang Jingjing , wang Yumeng , Midgley Adam , Lu Hongjiang , Song Guangzhou , Niu Fanhua , Shen Yufan , Zhang Yuexi 
Published: May 2023

Abstract
Injectable biomaterials have garnered increasing attention for their potential and beneficial applications in minimally invasive surgical procedures and tissue regeneration. Extracellular matrix (ECM) hydrogels and porous synthetic polymer microspheres can be prepared for injectable administration to achieve in situ tissue regeneration. However, the rapid degradation of ECM hydrogels and the poor injectability and biological inertness of most polymeric microspheres limit their pro-regenerative capabilities. Here, we developed a biomaterial system consisting of elastic porous poly(l-lactide-co-ε-caprolactone) (PLCL) microspheres mixed with ECM hydrogels as injectable composites with interleukin-4 (IL-4) and insulin-like growth factor-1 (IGF-1) dual-release functionality. The developed multifunctional composites had favorable injectability and biocompatibility, and regulated the behavior of macrophages and myogenic cells following injection into muscle tissue. The elicited promotive effects on tissue regeneration were evidenced by enhanced neomusle formation, vascularization, and neuralization at 2-months post-implantation in a rat model of volumetric muscle loss. Our developed system provides a promising strategy for engineering bioactive injectable composites that demonstrates desirable properties for clinical use and holds translational potential for application as a minimally invasive and pro-regenerative implant material in multiple types of surgical procedures.
Guide-Needle Angle and Sleeve Placement Evaluation on Skin Entry in Percutaneous Endoscopy Lumbar Discectomy Procedure Based on Three-dimensional Computed Tomography
Authors: Magetsari Rahadyan , Rukmoyo Tedjo , Wicaksono Andreas Wahyu , Sakti Yudha Mathan 
Published: May 2023

Abstract
Background: Low back pain and sciatic pain are some of the most common and infuriating pains. The prevalences are about 18-29%. The minimally invasive technique of spine decompression offers several advantages. One of the methods is percutaneous endoscopic lumbar discectomy (PELD) using the transforaminal approach. This study aimed to evaluate the needle angle and sleeve placement based on skin entry point using 3-dimensional (3D) computed tomography morphometric measurements.
Methods: The data were collected using 3D computed tomography morphometric measurements on the 4th – 5th lumbar. The parameters comprised several aspects of the vertebral morphometry. The vertebral AP length, spinous to skin length, AP vertebral body length, 30% of vertebral body length, and angle of the needle insertion data were collected. All the data were then analyzed using SPSS.
Results: There were 50 patients enrolled in this study. From vertebral morphometry, the average angle for the needle insertion for 4th lumbar spine in the coronal plane was 48.224 (± 4.138)°. The average distance of the needle insertion was 8.185 (±1.709) cm. The average twice the distance of the needle insertion was 16.370 (±3.417) cm and the average angle with the length doubled was 22.268 (±0.953)°. The average angle for 4th lumbar in the sagittal plane was 78.169 (±1.445)°.
Conclusion: We found the angle in the coronal plane for PELD in the 4th vertebra lumbar was 48.224°. The angle of insertion was 22.268° when the distance was doubled. The angle in the sagittal plane for PELD in the 4th lumbar spine was 78.169°.
Lever positioning manipulation alters real-time brain activity in patients with lumbar disc herniation: An amplitude of low- frequency fluctuation and regional homogeneity study
Authors: Zhou Xing-chen , Huang Yu-bo , Wu Shuang , Hong Shuang-wei , Tian Yu , Hu Hui-jie , Lv Li-jiang , Lv Zhi-zhen 
Published: May 2023

Abstract
Introduction
Lumbar disc herniation (LDH) is the preeminent disease of lever positioning manipulation (LPM), a complex disorder involving alterations in brain function. Resting-state functional magnetic resonance imaging (rs-fMRI) has the advantages of non-trauma, zero radiation, and high spatial resolution, which has become an effective means to study brain science in contemporary physical therapy. Furthermore, it can better elucidate the response characteristics of the brain region of LPM intervention in LDH. We utilized two data analysis methods, the amplitude of low-frequency fluctuation (ALFF) and regional homogeneity (ReHo) of rs-fMRI, to assess the effects of LPM on real-time brain activity in patients with LDH.
Methods
Patients with LDH (Group 1, n = 21) and age-, gender- and education-matched healthy controls without LDH (Group 2, n = 21) were prospectively enrolled. Brain fMRI was performed for Group 1 at two-time points (TPs): before LPM (TP1) and after one LPM session (TP2). The healthy controls (Group 2) did not receive LPM and underwent only one fMRI scan. Participants in Group 1 completed clinical questionnaires assessing pain and functional disorders using a Visual Analog Scale and the Japanese Orthopaedic Association (JOA), respectively.
Results
Compared to the healthy controls (Group 2), the patients with LDH (Group 1) had significant variation in ALFF and ReHo values in brain activity. After the LPM session (TP2), Group 1 at TP1 also showed significant variation in ALFF and ReHo values in brain activity. In addition, the latter (TP2 vs TP1) showed more significant changes in brain regions than the former (Group 1 vs Group 2). The ALFF values were increased in the Frontal_Mid_R and decreased in the Precentral_L in Group 1 at TP2 compared with TP1. The Reho values were increased in the Frontal_Mid_R and decreased in the Precentral_L in Group 1 at TP2 compared with TP1. The ALFF values were increased in the Precuneus_R and decreased in the Frontal_Mid_Orb_L in Group 1 compared with Group 2. Only three brain areas with significant activity in Group 1 compared with Group 2: Frontal_Mid_Orb_L, Frontal_Sup_Orb_L, and Frontal_Mid_R. ALFF value in the Frontal_Mid_R at TP2 correlated positively with the change rates of JOA scores between TP1 and TP2 (P = 0.04, r = 0.319, R2 = 0.102).
Discussion
Patients with LDH showed abnormal brain ALFF and ReHo values, which were altered after LPM. The default mode network, prefrontal cortex, and primary somatosensory cortex regions could predict real-time brain activity for sensory and emotional pain management in patients with LDH after LPM.
Low Tacrolimus trough concentration and high intra-patient variability are associated with chronic lung allograft dysfunction and mortality in lung transplantation recipients
Authors: Du Wenwen , Wang Xiaoxing , Zhang Dan , Chen Wenqian , Qin Wei , Li Shu , Zuo Xianbo , Li Pengmei 
Published: May 2023

Abstract
Background Erratic tacrolimus (Tac) exposure is associated with poor long-term outcomes after kidney transplantation. However, detailed data on the association in lung transplant recipients are lacking.Aim We hypothesized that Tac intra-patient variability (Tac IPV) or mean concentration was associated with chronic lung allograft dysfunction (CLAD) and survival after lung transplantation.Methods Data from 132 lung transplant recipients were analyzed retrospectively. Tac trough concentration during 0–6, 6–12 and 12–24 months after transplantation were collected. Tac IPV was calculated based on coefficient of variation. Univariate and multivariate COX analyses were performed to identify risk factors for CLAD and survival.Results Of the 132 patients analyzed, 31 (23.5%) developed CLAD and 20 (15.2%) died. Patients received significantly more intensive monitoring of Tac concentration at 0–6 months and Tac IPV was the highest (median: 33.98%) at this period, while after 6 months it lowered to a relatively steady level. A higher mean concentration at 6–12 months [Hazard Ratio (HR) 0.358 (95% CI: 0.137–0.933)] and at 12–24 months [HR 0.351 (95% CI: 0.136–0.904)] was a protective factor for CLAD incidence, while a higher Tac IPV at 6–12 months [HR 2.839 (95% CI: 1.063–7.585)] was associated with increased risk of mortality.Conclusion Our data indicates that Tac mean concentration and IPV had significant impact on CLAD incidence and mortality in lung transplant recipients. Routine monitoring of Tac concentration and IPV may help identify in patients at increased risk for inferior long-term outcomes.
Construction and validation of an angiogenesis-related lncRNA signature to predict prognosis and immune landscape in colon adenocarcinoma
Authors: Lu Yunfei , Chen Yang , Wang Zhenling , Shen Hengyang , Xu Lei , Huang Changzhi , Wu Jingyu , Shao Yu , Zhang Hongqiang , Chen Tao , Qiu Lei , Fu Zan 
Published: May 2023

Abstract
Background Angiogenesis is critical for the progression, invasion, and metastasis of malignant tumors and is closely related to the prognosis of tumor patients. LncRNAs regulate tumor angiogenesis and progression and hold great promise as novel biomarkers and treatment targets for cancer. Since patients with progressive colon cancer have poor clinical outcomes, it is necessary to develop a novel risk model for patients with colon adenocarcinoma. In our study, we developed a risk model containing five lncRNAs to investigate the association between tumor angiogenesis and the prognosis of the patient and to predict the infiltration of the tumor immune microenvironment in COAD patients.Results The risk model independently predicted the prognosis of COAD patients and supported clinical drug selection. There were significant differences in prognosis and immune infiltration between the high and low-risk groups. Patients in the high-risk group had a worse prognosis and higher expression of CD31, CD34, and CD105, while patients in the low-risk group had the opposite.Conclusions We constructed an angiogenesis-related signature to predict the prognosis and immune infiltration of COAD patients, demonstrating that our risk model is closely connected with the tumor microenvironment. The angiogenesis-related risk model can provide helpful insights into facilitating anti-angiogenic therapy and immunotherapy in COAD patients.
The effect of music intervention on cognitive aging: from the view of EEG microstates
Authors: Guo Sijia , Feng Liangfeng , Chen Jiaxian , Li Yan , Bian Haoyu , Li Longhan , Yang Hua , Lu Jing , Yao Dezhong 
Published: May 2023

Abstract
The effectiveness of music intervention on cognitive aging has been proved by many behavioral and clinical studies. However, the underlying neural mechanism remains to be explored. EEG microstate helps study the complex relationship of functional networks across cognitive and sensory functions such as working memory, attention, inhibitory control, and auditory and visual processing, which helps study the mechanism of music intervention on cognitive aging. In this work, we calculated EEG microstates parameters and found a lower duration of microstate D in old adults than that in young adults, and music training had a mitigating effect on this change. In addition, the age x music training experience interaction was significant for the transition rate between microstate D and microstates A, B, C. Combined with the correlation analysis between these parameters and working memory performance, and we thought that music training could prevent age-related cognitive decline which might relate to the ability to suppress task-irrelevant information in old adults. The underlying mechanism may be the top-down control of fronto-central regions on the sensory network. This work contributes to understanding the neural mechanism of music intervention on cognitive aging.
Existence and Verification of Nash Equilibria in Non-Cooperative Contribution Games with Resource Contention
Authors: Troquard Nicolas 
Published: May 2023

Abstract

In resource contribution games, a class of non-cooperative games, the players want to obtain a bundle of resources and are endowed with bags of bundles of resources that they can make available into a common for all to enjoy. Available resources can then be used towards their private goals.
A player is potentially satisfied with a profile of contributed resources when his bundle could be extracted from the contributed resources. Resource contention occurs when the players who are potentially satisfied, cannot actually all obtain their bundle. The player’s preferences are always single-minded (they consider a profile good or they do not) and parsimonious (between two profiles that are equally good, they prefer the profile where they contribute less). What makes a profile of contributed resources good for a player depends on their attitude towards resource contention.
We study the problem of deciding whether an outcome is a pure Nash equilibrium for three kinds of players’ attitudes towards resource contention: public contention-aversity, private contention-aversity, and contention-tolerance.
In particular, we demonstrate that in the general case when the players are contention-averse, then the problem is harder than when they are contention-tolerant. We then identify a natural class of games where, in presence of contention-averse preferences, it becomes tractable, and where there is always a Nash equilibrium.
Construction of nanoparticle array membranes by tumour metastasis-inspired self-seeded phase inversion for microplastic wastewater treatment
Authors: Ma Yu , He Bin 
Published: May 2023

AbstractIn a typical phase inversion-fabricated membrane, the arrangements and sizes of polymers are random, which generates a wide pore size distribution. Larger pores in the membrane result in inadequate rejection of pollutants; therefore, the designed membrane must feature a mean pore size smaller than the theoretical size to achieve high rejection of pollutants. However, the flow resistance of the membrane significantly increases with a reduction in the mean pore size, which considerably decreases the membrane flux. Herein, inspired by tumour metastasis, we present “self-seeded phase inversion (SSPI)”. This technique utilises partial dissolution of polyvinylidene fluoride nanoparticles to produce seed crystals that are uniformly distributed by vacuum filtration to induce non-solvent induced phase inversion (NIPS). Using this process, nanoparticle array membranes with uniform sizes and regular arrangements can be prepared in a simple, controllable, and practical mannerviafiltration at room temperature and NIPS. Because of their narrow pore-size distributions, low pore tortuosities, and low thicknesses, the obtained membranes demonstrate higher fluxes and rejection of microplastics with sizes similar to the pore sizes of the membranes. SSPI provides a facile way to overcome the current constraints of water-treatment membrane technology, which can facilitate the sustainable development of water-treatment membrane technology and has the potential for wider applications.
Single-trial EEG analysis reveals burst structure during photic driving
Authors: Oppermann Hannes , Thelen Antonia , Haueisen Jens 
Published: May 2023

Abstract
Photic driving in the human visual cortex evoked by intermittent photic stimulation is usually characterized in averaged data by an ongoing oscillation showing frequency entrainment and resonance phenomena during the course of stimulation. We challenge this view of an ongoing oscillation by analyzing unaveraged data. 64-channel EEGs were recorded during visual stimulation with light flashes at eight stimulation frequencies for fourteen healthy volunteers. Time-frequency analyses were performed in averaged and unaveraged data. While we find ongoing oscillations in the averaged data during intermittent photic stimulation, we find transient events (bursts) of activity in the unaveraged data. Both resonance and entrainment occur for the ongoing oscillations in the averaged data and the bursts in the unaveraged data. We argue that the continuous oscillations in the averaged signal may be composed of brief, transient bursts in single trials. Our results can also explain previously observed amplitude fluctuations in averaged photic driving data. Single trail analyses might consequently improve our understanding of resonance and entrainment phenomena in the brain.
Carbon ion irradiation combined with PD-1 inhibitor trigger abscopal effect in Lewis lung cancer via a threshold dose
Authors: Liu Ruifeng , Geng Yichao , Luo Hongtao , Zhang Qiuning , Yang Zhen , Sun Shilong , Liu Zhiqiang , Dong Meng , Du Tianqi , Che Tuanjie , Wang Xiaohu 
Published: May 2023

Abstract
Background and purpose Carbon ion is radiobiologically more effective than photons and are beneficial for treating radioresistant tumors, several animal experiment with tumor-bearing suggest that carbon ion beam irradiation in combination with immunotherapy yields better results, especially in controlling distant metastases, which suggests that carbon ion beam induces a different anti-tumor immune response than photon beam, more complex molecular mechanisms need to be further explored. We conduct this in vivo and in vitro experiment was to investigate the radio-immune effects and its mechanism of different LET rays combined PD-1 inhibitors.Methods and Materials: Lewis lung adenocarcinoma cells and C57BL/6 mice were stablished tumor-bearing mouse model, the irradiated tumor located on the left back and the non-irradiated tumor located on the right hind limb. The left back tumor was irradiated with 10Gy X-ray or carbon ion beam, combined with or without PD-1 inhibitor. Immunohistochemistry was used to detect the expression of immunogenicity-related molecules and the infiltration of CD8 + T cells in tumor tissues. ELISA was used to detect the changes of IFN-β in mouse serum, and flow cytometry was used to detect the changes of CD8 + T cells in mouse peripheral blood. Lewis cells were irradiated with different doses of X-ray and carbon ion. The changes of TREX1, PD-L1, and IFN-β in mRNA and protein levels were detected with RT-PCR or Western blot respectively. TREX1 knockdown were constructed by siRNA transfection and irradiated with different rays. Changes in cell proliferation, viability, apoptosis rate were detected using CCK8 assay, BrdU assay, and flow cytometry.Results X-ray or carbon ion combined with αPD-1 had a significant inhibitory effect on bilateral tumors, especially carbon ion in non-irradiated side tumor(p < 0.05). 10 Gy carbon ion irradiation enhanced the proportion of infiltrating CD8 + T cells and the expression level of IFN-β in irradiated side tumor, however, it also increased PD-L1 and TREX1 expression level. Lewis cell in vitro experiment further confirmed that both X-ray and carbon ion irradiation can up-regulate the expression levels of PD-L1 and TREX1 with dose-dependent in tumor, especially the trend of up-regulation TREX1 is more obvious at a higher dose in carbon ions, i.e 8 or 10Gy, while the level of IFN-βis decreased. By gene silencing TREX1, IFN-βlevels were also significantly increased under hypofractioned dose with carbon ion irradiation.Conclusions The combination of X-ray or carbon ion irradiation and PD-1 inhibitors produce better anti-tumor effect and trigger abscopal effect on Lewis lung adenocarcinoma bearing mice through enhanced tumor immunogenicity and increased CD8 + T infiltration in TME via a threshold dose. TREX1 could serve as a prognostic marker and potential target of immunotherapy.
Based polymer nanoparticles from bee pollen attenuate non-small lung cancer through enhancement of apoptosis and cell cycle arrest in vivo
Authors: Salim Elsayed I. , Mahfouz Magdy E. , Eltonouby Eman A. , Hamed Ezar H. , hanafy nemany 
Published: May 2023

Abstract
Bee pollen extract (BPE)-based polymer nanoparticles (BPENP) were fabricated by using bovine serum albumin (BSA) and targeted with folic acid and were further characterized. Mice groups are : Group 1 received saline, whereas Groups 2, 3, 4, 5, and 6 received a single dose of urethane, followed by weekly injections of butylated hydroxy-toluene (BHT). After the BHT injection, the mice in Groups 3, 4, 5, and 6 received BPE, Avastin,BPENP, and BNENP + Avastin, respectively. The number and size of tumors decreased in Group 6 compared to those in the other groups. The ratios of early and late apoptotic cells in Groups 3, 4, 5, and 6 (42.8%, 41.4%, 26.2%, and 45.4%, respectively) were lower than that in the untreated group. The PCNA-labeling indices (LI)% in tissues and lesions from Group 6 were lower than those in the other groups; on the other hand, the caspase 3 LI (%) was higher than those in the other groups. No significant differences in HRAS and MAPK levels were observed between Group 6 and the other groups. However, the level of Baxwas significantly increased, whereas those of Bcl2 and P21 were decreased in Group 6 compared to those in Groups 4 and 5.
Clinical characteristics and prognosis of acute pulmonary embolism with hemoptysis in autoimmune disease patients
Authors: Li Yiyao , Peng Min , Yang Jianian , Xue Peijun , Shi Juhong 
Published: May 2023

Abstract
Background Hemoptysis is prevalent in acute pulmonary embolism (PE) and holds a significant bearing on clinical decision-making. Although PE is increasingly reported in autoimmune disease patients, few studies have examined the association between acute PE with hemoptysis and autoimmune disease.Methods This retrospective study evaluated autoimmune disease patients presenting with acute PE and hemoptysis at Peking Union Medical College Hospital (PUMCH) between January 2012 and October 2020. Hemoptysis and non-hemoptysis patients were compared, and autoimmune disease patients were compared to those without autoimmune disease. Clinical characteristics, PE risk stratification, hemoptysis amount, initial anticoagulation management, and prognosis were analyzed descriptively.Results The study analyzed 896 patients diagnosed with acute pulmonary embolism, of which 105 (11.7%) presented with hemoptysis. Hemoptysis was often associated with autoimmune diseases, with a younger patient population, lower-risk PE, and milder volume of hemoptysis. Most patients received therapeutic-dose anticoagulation, and the autoimmune disease subgroup had a higher survival rate (97.5%) compared to the non-autoimmune subgroup (82.8%) with statistical significance (p = 0.022). Patients were grouped based on maximum daily blood volume and PE risk stratification, receiving different treatments and having a hierarchical prognosis.Conclusions It is crucial to consider the underlying cause of hemoptysis in acute PE diagnosis and effectively treat the primary autoimmune disease. Therapeutic decisions should balance PE risk stratification and hemoptysis volume.