bluuebunny/crossref_metadata_2025_split huggingface dataset:
Milestones on the Quantum Utility Highway: Quantum Annealing Case Study
Authors: McGeoch Catherine C. , Farré Pau 
Published: September 2023

We introduce
quantum utility
, a new approach to evaluating quantum performance that aims to capture the user experience by considering the overhead costs associated with a quantum computation. A demonstration of quantum utility by the quantum processing unit (QPU) shows that the QPU can outperform classical solvers at some tasks of interest to practitioners, when considering the costs of computational overheads. A milestone is a test of quantum utility that is restricted to a specific subset of overhead costs and input types.

We illustrate this approach with a benchmark study of a D-Wave annealing-based QPU versus seven classical solvers for a variety of problems in heuristic optimization. We consider overhead costs that arise in standalone use of the D-Wave QPU (as opposed to a hybrid computation). We define three early milestones on the path to broad-scale quantum utility. Milestone 0 is the purely quantum computation with no overhead costs and is demonstrated implicitly by positive results on other milestones. We evaluate the performance of a D-Wave Advantage QPU with respect to milestones 1 and 2: For milestone 1, the QPU outperformed all classical solvers in 99% of our tests. For milestone 2, the QPU outperformed all classical solvers in 19% of our tests, and the scenarios in which the QPU found success correspond to cases where classical solvers most frequently failed.
This approach of isolating subsets of overheads for separate analysis reveals distinct mechanisms in quantum versus classical performance, which explain the observed differences in patterns of success and failure. We present evidence-based arguments that these distinctions bode well for annealing quantum processors to support demonstrations of quantum utility on ever-expanding classes of inputs and with more challenging milestones in the very near future.
Detection of heart pathology using deep learning methods
Authors: Naizagarayeva Akgul , Abdikerimova Gulzira , Shaikhanova Aigul , Glazyrina Natalya , Bekmagambetova Gulmira , Mutovina Natalya , Yerzhan Assel , Tanirbergenov Adilbek 
Published: September 2023

<span lang="EN-US">In the directions of modern medicine, a new area of processing and analysis of visual data is actively developing - a radio municipality - a computer technology that allows you to deeply analyze medical images, such as computed tomography (CT), magnetic resonance imaging (MRI), chest radiography (CXR), electrocardiography and electrocardiography. This approach allows us to extract quantitative texture signs from signals and distinguish informative features to describe the heart's pathology, providing a personified approach to diagnosis and treatment. Cardiovascular diseases (SVD) are one of the main causes of death in the world, and early detection is crucial for timely intervention and improvement of results. This experiment aims to increase the accuracy of deep learning algorithms to determine cardiovascular diseases. To achieve the goal, the methods of deep learning were considered used to analyze cardiograms. To solve the tasks set in the work, 50 patients were used who are classified by three indicators, 13 anomalous, 24 nonbeat, and 1 healthy parameter, which is taken from the MIT-BIH Arrhythmia database.</span>
An improved YOLOv5 for real-time human detection in infrared images
Authors: Khalfaoui Aicha , Badri Abdelmajid , El Mourabit Ilham 
Published: September 2023

<span>The recent prominence of using infrared technology for human detection has garnered attention, particularly for applications in intelligent video surveillance and self-driving systems. This technology offers advantages in adverse weather conditions and night vision. However, within deep learning, the challenge of variable illumination during human detection persists. This study presents a novel method for identifying individuals in thermal images by enhancing the you only look once (YOLOv5s) algorithm. The approach incorporates the Bi-directional feature pyramid network (BiFPN) and the convolutional block attention module (CBAM) to improve the model’s feature integration and extraction capabilities. Evaluation on established thermal imaging datasets confirms the method’s superiority over state-of-the-art convolutional neural networks (CNN) based techniques, achieving remarkable precision 99.1% and recall 96.9%.</span>
A decision tree approach based on BOCR for minimizing criteria in requirements prioritization
Authors: Amelia Tan , Mohamed Rozlina 
Published: September 2023

<span>The requirements selection in the development of a software mostly requires a set of criteria. Determining the criteria used is often confusing because of the many criteria that must match with the characteristics of the project. This study introduces how to classify criteria based on benefits, opportunities, costs, risks (BOCR) to make the requirements prioritization process scalable. Project context characteristics and stakeholder perspectives are essential points discussed in this study because they are crucial in the requirements prioritization process. The criteria obtained from the literature review were followed by a survey to determine the importance of the criteria and their grouping in the BOCR using the decision tree method. There are 38 criteria and are grouped into four categories. There are two very significant criteria with a high level of importance, namely business value and stakeholder satisfaction. A decision tree based on BOCR can be used to classify the criteria for requirements prioritization. This research contributes to assisting software developers in finding and determining the criteria operated during the prioritization of requirements. Additionally, it is important to consider the project context and the collaboration the client and developer when prioritizing requirements.</span>
Implementation of a radio frequency identification and detection technology based digital class attendance system for university students
Authors: Ohanu Chibuike Peter , Christiana Ugbe Oluchi , Ogbuefi Uche C. , Sutikno Tole 
Published: September 2023

Class attendance is a key consideration when assigning final marks for courses taught, student attendance is a critical issue for higher institutions. Some institutions choose to regulate attendance with paper sheets, while others prefer to verify students' attendance with paper sheets and then manually enter this information into a computer. This mode of taking students attendance delays time and reduces the time needed for the lecture to be delivered. A system that eases the burden of time delay in taking attendance, promotes the universities, and supports parents is presented in this paper. The radio frequency identification and detection (RFID) student monitoring system has been developed to track student’s attendance in the classroom using passive RFID technology. The system uses an RFID reader and a contactless smart card to ensure time management during student’s attendance. A reader at a fixed place delivers a signal to a passive RFID chip for detection and identifies a huge number of chips in a short amount of time. The biometric thumb detection module for security was applied to improve the system. The applied enhanced technology sends a message to the parent of any students that fails to attend lectures.
Energy efficient routing protocols in wireless body area networks for health monitoring: a review
Authors: Al-Sofi Soleen Jaladet , Atroshey Salih Mustafa S. , Ali Ismail Amin 
Published: September 2023

<span>Technology nowadays is developing at an unprecedented pace in the field of wireless sensor networks (WSN). Especially in the aftermath of the pandemic, wireless body area networks (WBAN), which is a sub-category of WSN, experiences huge prominence, due to its functionality to enable remote diagnosis, treatment, and constant monitoring for patients. This functionality is a great advantage, since it allows elderly people, people with chronical diseases and even emergency cases to be monitored in real-time and, if needed, also enabling timely interventions. Furthermore, it is very cost-efficient since it reduces the occupation of hospital beds, whilst also keeping patients safer. This is possible by deploying small sensors within or around the body, where they can gather physiological data, which then at the end is send to medical terminals, where medical staff have access to them. However, a WBAN, due to its small size, is constricted by several factors. Energy consumption, security, data transmission, as well as heat generation are only a few to be named. To deal with these challenges, whilst enabling a stable communication between the components, routing protocols are required. There are many different routing protocols which are used depending on the application being used. </span>
Legal Underpinnings Drive ESG Amidst Global Flux
Authors: Gossain Rahul 
Published: September 2023

The paper studies the complex global dynamics governing Environmental, Social, and Governance (ESG), including the evolving scope and structures of ESG frameworks. The impact of the significant expansion in the scope and spread of legal underpinnings over the last decade studied along with the increase in strategic applications of ESG like risk management. There is specific focus on developments the European Union, and an assessment of the impact of the changing ESG and regulatory scenario on India. The accelerated alignment of reporting standards, post the release of Task Force on Climate-Related Financial Disclosures (TCFD) guidelines has been complemented by legal and regulatory progress globally. The gradual development of legal underpinnings has put ESG or business sustainability on a stronger footing, by providing binding mandates to transition towards sustainability, albeit in varying in strength and forms across jurisdictions. The paper studies the development of these legal underpinnings and analyses how it has been critical in ensuring progress on the ESG front. These were critical in ensuring progress continued despite significant headwinds emerging of the Ukraine War and COVID-19, albeit in a slower but sustained manner. This contrasted with the scenario over the last four decades wherein vested interests could easily derail progress on climate change fronts in the absence of the legal underpinnings and binding mandates. This analysis is based on study of recent sustainability mechanisms, including a study of the architecture of the Paris Agreement, the TCFD guidelines, the compliance-based European Union (EU) Sustainability Action Plan in EU, and other international regulatory developments, including India’s BRSR and the recent regulatory proposals by RBI and SEBI etc. Global financial investors’ strong push for ESG based risk-assessment and investments is analysed along with the introduction of mandated ESG compliances for businesses and trade is pushing companies and countries with older ESG standards to respond, which has important implication for India and Indian businesses.
Primary care providers’ perceptions on the integration of community-led advance care planning activities with primary care: a cross-sectional survey
Authors: Carter Rachel Z , Ludwig Monika , Gao Angela , Tan Amy , Barwich Doris , Howard Michelle 
Published: September 2023

Abstract
Background
Advance care planning (ACP) is a process intended to help ensure people receive medical care that is consistent with their values, goals, and preferences during serious and chronic illness. Barriers to implementing ACP in primary care settings exist. Community-led ACP initiatives exist in British Columbia to engage the public directly. These initiatives may help prepare people for conversations with their primary care providers. The objectives of this study were to elicit primary care providers’ perceptions of the utility and desired content of community-led ACP activities and suggestions for integrating community-led ACP activities with primary care.

Methods
We conducted an online cross-sectional survey of primary care providers practicing in British Columbia, Canada in 2021. Both quantitative and qualitative survey questions addressed ACP engagement in practice, the perceived role and desired outcomes of community-led ACP activities, and ways to integrate community-led ACP activities with primary care.

Results
Eighty-one providers responded. Over 80% perceived a moderate or greater potential impact of community-led ACP activities. The most common reasons for not referring a patient to a community-led ACP activity were lack of awareness of the option locally (62.1%) and in general (44.8%). Respondents wanted their patients to reflect on their values, wishes and preferences for care, to have at least thought about their goals of care and to have chosen a substitute decision maker in the community. They indicated a desire for a summary of their patient’s participation and a follow-up discussion with them about their ACP. They suggested ways to integrate referral to programs into existing health care system structures.

Conclusions
Community-led ACP activities were perceived to be useful to engage and prepare patients to continue ACP discussions with clinicians. Efforts should be made to establish and integrate community-based ACP initiatives within existing primary care systems to ensure awareness and uptake.
FIL SSF intraocular lens opacification after pars plana vitrectomy with gas tamponade for traumatic lens luxation and retinal detachment: a case report and literature review
Authors: Iannetta Danilo , Febbraro S. , Valsecchi N. , Moramarco A. , Fontana L. 
Published: September 2023

Abstract
Background
To report a case of sutureless scleral-fixated hydrophilic intraocular lens (FIL SSF IOL, Soleko, Italy) opacification following pars plana vitrectomy surgery using sulfur hexafluoride (SF6) for traumatic lens luxation associated with retinal detachment.

Case presentation
A 77-year-old woman was referred to our emergency department after blunt trauma in her right eye. At the ophthalmic evaluation, visual acuity was hand movement, biomicroscopy showed pseudoexfoliation syndrome and a traumatic lens luxation in the vitreous chamber. The patient underwent pars plana vitrectomy, subluxated cataract explantation, and FIL SSF IOL implant. During surgery, an inferior retinal detachment was encountered, requiring 20% SF6 gas tamponade. No adverse events were encountered. One month postoperatively, visual acuity (BCVA) improved to 0,3 logMAR. At the 3-month follow-up, the patient presented with BCVA of 0,5 logMAR, and biomicroscopy showed a minimal IOL opacification. Six months postoperatively, BCVA decreased to 1.0 logMAR, and diffuse, IOL opacification was noted at slit lamp examination. The patient refused any other surgical intervention for IOL exchange.

Conclusions
Although hydrophilic IOL opacification gas related is known, to the best of our knowledge, this is the first case reported in the literature of FIL SSF IOL opacification after pars plana vitrectomy with gas tamponade for retinal detachment.
Interventional pulmonary procedures and their outcomes in patients with STAT3 hyper IgE syndrome
Authors: Mahdaviani Seyed Alireza , Ghadimi Soodeh , Fallahi Mazdak , Hashemi-Moghaddam Seyedeh Atefeh , Chavoshzadeh Zahra , Puel Anne , Rezaei Nima , Rekabi Mahsa , Daneshmandi Zahra , Sheikhy Kambiz , Kakhki Abolghasem Daneshvar , Saghebi Seyed Reza , Pejhan Saviz , Jamee Mahnaz 
Published: September 2023

Abstract
Background
STAT3 hyperimmunoglobulin E syndrome (STAT3-HIES) also referred to as autosomal dominant HIES (AD-HIES) is an inborn error of immunity characterized by the classic triad of eczema, frequent opportunistic infections, and elevated serum IgE levels. As a consequence of lung sequels due to repeated infections and impaired tissue healing, patients may require interventional pulmonary procedures.

Method
Four patients with dominant-negative STAT3 mutations who had received interventional pulmonary procedures were enrolled. The demographic, clinical, and molecular characteristics were gathered through a medical record search. All reported STAT3-HIES patients in the literature requiring pulmonary procedures as part of their treatment were reviewed.

Result
Recurrent episodes of pneumonia and lung abscess were the most prevalent symptoms. The most common non-immunological features were scoliosis, failure to thrive, and dental problems such as primary teeth retention and disseminated decays. Bronchiectasis, lung abscess, pneumatocele, and cavitary lesion were the most prevalent finding on high-resolution computed tomography at the earliest recording. All patients underwent pulmonary surgery and two of them experienced complications.

Conclusion
Patients with STAT3-HIES have marked pulmonary infection susceptibility which may necessitate thoracic surgeries. Since surgical procedures involve a high risk of complication, surgical options are recommended to be utilized only in cases of drug resistance or emergencies.
Synergistic effects of flavonoids and paclitaxel in cancer treatment: a systematic review
Authors: Asnaashari Solmaz , Amjad Elham , Sokouti Babak 
Published: September 2023

AbstractPaclitaxel is a natural anticancer compound with minimal toxicity, the capacity to stabilize microtubules, and high efficiency that has remained the standard of treatment alongside platinum-based therapy as a remedy for a variety of different malignancies. In contrast, polyphenols such as flavonoids are also efficient antioxidant and anti-inflammatory and have now been shown to possess potent anticancer properties. Therefore, the synergistic effects of paclitaxel and flavonoids against cancer will be of interest. In this review, we use a Boolean query to comprehensively search the well-known Scopus database for literature research taking the advantage of paclitaxel and flavonoids simultaneously while treating various types of cancer. After retrieving and reviewing the intended investigations based on the input keywords, the anticancer mechanisms of flavonoids and paclitaxel and their synergistic effects on different targets raging from cell lines to animal models are discussed in terms of the corresponding involved signaling transduction. Most studies demonstrated that these signaling pathways will induce apoptotic / pro-apoptotic proteins, which in turn may activate several caspases leading to apoptosis. Finally, it can be concluded that the results of this review may be beneficial in serving as a theoretical foundation and reference for future studies of paclitaxel synthesis, anticancer processes, and clinical applications involving different clinical trials.
The pyrazole derivative of usnic acid inhibits the proliferation of pancreatic cancer cells in vitro and in vivo
Authors: Gimła Mariola , Pyrczak-Felczykowska Agnieszka , Malinowska Marcelina , Hać Aleksandra , Narajczyk Magdalena , Bylińska Irena , Reekie Tristan A. , Herman-Antosiewicz Anna 
Published: September 2023

Abstract
Background
Pancreatic cancer is one of the leading causes of cancer death in Western societies. Its late diagnosis and resistance to chemotherapies result in a high mortality rate; thus, the development of more effective therapies for the treatment of pancreatic cancer is strongly warranted. Usnic acid (UA) is a secondary metabolite of lichens that shows modest antiproliferative activity toward cancer cells. Recently, we reported the synthesis of a UA pyrazole derivative, named 5, which was more active than the parent compound toward cervical cancer cells. Here, its anticancer potential has been evaluated in detail in other cancer cells, particularly pancreatic cancer cells.

Methods
The impact of UA and derivative 5 on cell viability, morphology, cell cycle, and death was assessed using the MTT test, electron microscopy, flow cytometry, and immunoblotting, respectively. The calcium ions level was detected fluorometrically. In vivo, the anticancer activity of 5 was evaluated in a murine xenograft model.

Results
Derivative 5 inhibited the viability of different cancer cells. Noncancerous cells were less sensitive. It induced the release of calcium ions from the endoplasmic reticulum (ER) and ER stress, which was manifested by cell vacuolization. It was accompanied by G0/G1 cell cycle arrest and cell death of pancreatic cancer cells. When applied to nude mice with xenografted pancreatic cancer cells, 5 inhibited tumor growth, with no signs of kidney or liver toxicity.

Conclusions
UA derivative 5 is superior to UA inhibiting the growth and proliferation of pancreatic cancer cells. ER stress exaggeration is a mechanism underlying the activity of derivative 5.
GMP-grade human neural progenitors delivered subretinally protect vision in rat model of retinal degeneration and survive in minipigs
Authors: Lu Bin , Avalos Pablo , Svendsen Soshana , Zhang Changqing , Nocito Laura , Jones Melissa K. , Pieplow Cosmo , Saylor Joshua , Ghiam Sean , Block Amanda , Fernandez Michael , Ljubimov Alexander V. , Small Kent , Liao David , Svendsen Clive N. , Wang Shaomei 
Published: September 2023

Abstract
Background
Stem cell products are increasingly entering early stage clinical trials for treating retinal degeneration. The field is learning from experience about comparability of cells proposed for preclinical and clinical use. Without this, preclinical data supporting translation to a clinical study might not adequately reflect the performance of subsequent clinical-grade cells in patients.

Methods
Research-grade human neural progenitor cells (hNPC) and clinical-grade hNPC (termed CNS10-NPC) were injected into the subretinal space of the Royal College of Surgeons (RCS) rat, a rodent model of retinal degeneration such as retinitis pigmentosa. An investigational new drug (IND)-enabling study with CNS10-NPC was performed in the same rodent model. Finally, surgical methodology for subretinal cell delivery in the clinic was optimized in a large animal model with Yucatan minipigs.

Results
Both research-grade hNPC and clinical-grade hNPC can survive and provide functional and morphological protection in a dose-dependent fashion in RCS rats and the optimal cell dose was defined and used in IND-enabling studies. Grafted CNS10-NPC migrated from the injection site without differentiation into retinal cell phenotypes. Additionally, CNS10-NPC showed long-term survival, safety and efficacy in a good laboratory practice (GLP) toxicity and tumorigenicity study, with no observed cell overgrowth even at the maximum deliverable dose. Finally, using a large animal model with the Yucatan minipig, which has an eye size comparable to the human, we optimized the surgical methodology for subretinal cell delivery in the clinic.

Conclusions
These extensive studies supported an approved IND and the translation of CNS10-NPC to an ongoing Phase 1/2a clinical trial (NCT04284293) for the treatment of retinitis pigmentosa.

Graphical abstract