bluuebunny/crossref_metadata_2025_split huggingface dataset:
Randomized Trial Comparing Left Colon Mucus Production Using Water Versus Saline During Water Exchange Colonoscopy
Authors: Cheng Chi-Liang , Kuo Yen-Lin , Liu Nai-Jen , Lien Jau-Min , Su I-Chia , Tang Chia-Pei , Hsieh Yu-Hsi , Leung Felix W. 
Published: May 2023

Abstract

INTRODUCTION
Water-assisted colonoscopy increases left colon mucus production; however, the effect of saline on mucus production is unclear. We tested the hypothesis that saline infusion may reduce mucus production in a dose-related manner.

METHODS
In a randomized trial, patients were assigned to colonoscopy with CO2 insufflation, water exchange (WE) with warm water, 25% saline, or 50% saline. The primary outcome was the Left Colon Mucus Scale (LCMS) score (5-point scale). Blood electrolytes were measured before and after saline infusion.

RESULTS
A total of 296 patients with similar baseline demographics were included. The mean LCMS score for WE with water was significantly higher than that for WE with saline and CO2 (1.4 ± 0.8 [WE water] vs 0.7 ± 0.6 [WE 25% saline] vs 0.5 ± 0.5 [WE 50% saline] vs 0.2 ± 0.4 [CO2]; overall P < 0.0001), with no significant difference between the 25% and 50% saline groups. The left colon adenoma detection rate (ADR) was highest in the 50% saline group, followed by the 25% saline and the water groups (25.0% vs 18.7% vs 13.3%) but the difference was not significant. Logistic regression showed water infusion as the only predictor of moderate mucus production (odds ratio, 33.3; 95% confidence interval, 7.2-153.2). No acute electrolyte abnormalities were documented indicating a safe modification.

CONCLUSIONS
The use of 25% and 50% saline significantly inhibited mucus production and numerically increased ADR in the left colon. Evaluation of the impact of mucus inhibition by saline on ADR may refine the outcomes of WE.
Hubungan Self-Efficacy dengan Academic Resilience Dimediasi Self-Regulated Learning pada Mahasiswa di Masa Pandemi COVID-19
Authors: Yoelianita Betty Erda , Toga Ervia 
Published: May 2023

Introduction: The COVID-19 pandemic had affected of higher education, especially nursing students in online clinical practice learning. The impact of online learning was students difficulties and limitations in direct clinical learning. A significant decrease in the statistical value of nursing practice pre-pandemic and during the pandemic in this situation, students with adaptive responses through their capacity used self-regulated learning (SRL) and academic resilience strategies. This study aimed to examine the role of SRL as a mediator of the correlation between self-efficacy and academic resilience at bachelor of nursing students during the Covid-19 pandemic. Methods: This study used a quantitative approach with a cross-sectional study design. The research sample consisted of 138 bachelor of nursing students at a health institution in East Java, taken using purposive sampling techniques. The inclusion criteria were bachelor of nursing students, who had practiced clinial at hospitals or other practice areas, during the Covid-19 pandemic. The research instrument used self-efficacy scale (17 items), academic resilience scale (25 items), and SRL scale (39 items). Data analysis used analyze regression Process Hayes Version 4.0 with the IBM SPSS (Statistical Program for Social Science) version 25 program for windows. Results: The results showed that there was a positive and significant correlation between self-efficacy and academic resilience, either directly (β=1.396, p=0.000) or partially mediated by SRL (β=0.7126, p=0.000), which mean that students with high self-efficacy can increase academic resilience with the mediating role of SRL.Conclusion: Self-efficacy has a positive and significant effect on academic resilience, either directly or partially mediated by SRL. Keywords: Academic Resilience, Self-Efficacy, Self-Regulated Learning.
ESTIMASI RISIKO PORTOFOLIO SAHAM PERUSAHAAN PERKEBUNAN DI BURSA EFEK INDONESIA MENGGUNAKAN VALUE AT RISK NON-NORMAL
Authors: Ikhsan Aulia , Sutisna Tatang , Widiati Siti 
Published: May 2023

Stock investment portfolio aims to minimize the investment risk. However, problems of the portfolio formation are determining funds allocation for each stock and measuring its risk. Fund allocation is determined using the Mean-Variance Efficient Portfolio method, while risk measurement is carried out using Value at Risk (VaR). Nevertheless, problem on VaR is determining a fit distribution which would be involved to obtain quantile values at certain probability. This study discusses way of funds allocation determination and VaR value calculation that is aimed to analyze their impact in estimating the VaR value. The study used stock price return rate data of plantation companies listed on Indonesia Stock Exchange such as Astra Agro Lestari Tbk. (AALI), BISI International Tbk. (BISI), and PP London Sumatra Indonesia Tbk. (LSIP). The result showed BISI stock has high volatility so that its funds allocation is relatively smaller. The distribution identified for portfolio return rate is Logistics Distribution with the estimated parameters 0.0001187447 and 0.008810698. Portfolio VaR value at the 95% confidence level is -0.02582382. We conclude the determination of funds allocation does not minimize risk and the calculation of VaR with distributions do not match the data result a relatively higher VaR value.
Optimal design of pressure swing adsorption units for hydrogen recovery under uncertainty
Authors: Golubyatnikov Oleg , Akulinin Evgeny , Dvoretsky Stanislav 
Published: May 2023

Abstract
The paper proposes an approach to the optimal design of pressure swing adsorption (PSA) units for hydrogen recovery under uncertainty, which provides a reasonable margin of the potential resource of the PSA hydrogen unit and compensates for the negative impact of a random change in uncertain parameters within specified limits. A heuristic iterative algorithm is proposed to solve the design problem with a profit criterion, which is guaranteed to provide the technological requirements for the PSA unit, regardless of the values that take uncertain parameters from the specified intervals of their possible change. An experimental verification of the approach with the root-mean-square error of 19.43 % has been carried out. Optimization problems of searching for a combination of mode and design parameters under uncertainty for a range of 4-bed 4-step VPSA units with a capacity of 100–2000 L/min STP have been solved taking into account the requirements for hydrogen purity of 99.99+ %, gas inlet velocity of 0.2 m/s, and bed pressure drop (no more than 1 atm). It has been established that taking into account uncertainties leads to an increase in energy costs by 8–10 %, a decrease in profit by 10–15 %, and a decrease in hydrogen recovery by 4–5 %, which is a payment for the uninterrupted operation of the PSA unit. The effect of uncertain parameters (percentage composition of the gas mixture; gas temperature; the diameter of adsorbent particles) on the key indicators of the PSA process (recovery, profit, hydrogen purity, unit capacity) has been established and trends in adsorption duration, adsorption and desorption pressure, P/F ratio, valve capacity, bed length, adsorber diameter for design of hydrogen PSA unit, which are necessary for subsequent design and scaling of units.
Determination of essential and toxic elements in Algerian plant Matricaria chamomilla L.
Authors: Kherraz Khaled , Messaoudi Mohammed , Benchikha Naima , Benmohamed Mokhtar , Bouhila Zohra , Azli Tarek , Ben Seghir Bachir , Rebiai Abdelkrim , Ouakouak Hamza , Benarfa Adel 
Published: May 2023

Abstract
The chamomile plant, Matricaria chamomilla L., is a well-known medicinal plant species that is widely utilized in folk and traditional medicine to provide sedative as well as spasmolytic effects. In the present study and for the first time in Algeria, we examined in particular the content of essential and toxic elements in the Algerian plant M. chamomilla L., by using two analytical techniques Instrumental neutron activation analysis (INAA) and Inductively Coupled Plasma Optical Emission Spectrometry (ICP-OES). The findings from the two analytical techniques showed that there were twenty-one elements, comprising macro and microelements, including Ba, Br, Ca, Cl, Co, Cr, Cs, Eu, Fe, K, Mg, Mn, Mo, Na, Rb, Sb, Sc, Sr, Th, U, and Zn. The accuracy of these methods was verified and confirmed by analyzing three certified reference materials. This study demonstrated the abundance of mineral elements in M. chamomilla L. Additionally, the concentration of the toxic elements determined were within the Food and Agriculture Organization’s tolerance limits (FAO).
Oncogenic stress‐induced Netrin is a humoral signaling molecule that reprograms systemic metabolism in Drosophila
Authors: Okada Morihiro , Takano Tomomi , Ikegawa Yuko , Ciesielski Hanna , Nishida Hiroshi , Yoo Sa Kan 
Published: May 2023

AbstractCancer exerts pleiotropic, systemic effects on organisms, leading to health deterioration and eventually to organismal death. How cancer induces systemic effects on remote organs and the organism itself still remains elusive. Here we describe a role for NetrinB (NetB), a protein with a particularly well‐characterized role as a tissue‐level axon guidance cue, in mediating oncogenic stress‐induced organismal, metabolic reprogramming as a systemic humoral factor. In Drosophila, Ras‐induced dysplastic cells upregulate and secrete NetB. Inhibition of either NetB from the transformed tissue or its receptor in the fat body suppresses oncogenic stress‐induced organismal death. NetB from the dysplastic tissue remotely suppresses carnitine biosynthesis in the fat body, which is critical for acetyl‐CoA generation and systemic metabolism. Supplementation of carnitine or acetyl‐CoA ameliorates organismal health under oncogenic stress. This is the first identification, to our knowledge, of a role for the Netrin molecule, which has been studied extensively for its role within tissues, in humorally mediating systemic effects of local oncogenic stress on remote organs and organismal metabolism.
A network of small RNAs regulates sporulation initiation in Clostridioides difficile
Authors: Fuchs Manuela , Lamm‐Schmidt Vanessa , Lenče Tina , Sulzer Johannes , Bublitz Arne , Wackenreuter Janet , Gerovac Milan , Strowig Till , Faber Franziska 
Published: May 2023

AbstractThe obligate anaerobic, enteric pathogen Clostridioides difficile persists in the intestinal tract by forming antibiotic‐resistant endospores that contribute to relapsing and recurrent infections. Despite the importance of sporulation for C. difficile pathogenesis, environmental cues and molecular mechanisms that regulate sporulation initiation remain ill‐defined. Here, by using RIL‐seq to globally capture the Hfq‐dependent RNA–RNA interactome, we discovered a network of small RNAs that bind to mRNAs encoding sporulation‐related genes. We show that two of these small RNAs, SpoX and SpoY, regulate translation of the master regulator of sporulation, Spo0A, in an opposing manner, which ultimately leads to altered sporulation rates. Infection of antibiotic‐treated mice with SpoX and SpoY deletion mutants revealed a global effect on gut colonization and intestinal sporulation. Our work uncovers an elaborate RNA–RNA interactome controlling the physiology and virulence of C. difficile and identifies a complex post‐transcriptional layer in the regulation of spore formation in this important human pathogen.
DOHaD: A Menagerie of Adaptations and Perspectives: The interplay between early embryo metabolism and mitoepigenetic programming of development
Authors: Bruna de Lima Camila , Cristina dos Santos Érika , Sirard Marc-André 
Published: May 2023

In brief
This review discusses advances in the knowledge of epigenetic mechanisms regulating mitochondrial DNA and the relationship with reproductive biology.

Abstract
Initially perceived simply as an ATP producer, mitochondria also participate in a wide range of other cellular functions. Mitochondrial communication with the nucleus, as well as signaling to other cellular compartments, is critical to cell homeostasis. Therefore, during early mammalian development, mitochondrial function is reported as a key element for survival. Any mitochondrial dysfunction may reflect in poor oocyte quality and may impair embryo development with possible long-lasting consequences to cell functions and the overall embryo phenotype. Growing evidence suggests that the availability of metabolic modulators can alter the landscape of epigenetic modifications in the nuclear genome providing an important layer for the regulation of nuclear-encoded gene expression. However, whether mitochondria could also be subjected to such similar epigenetic alterations and the mechanisms involved remain largely obscure and controversial. Mitochondrial epigenetics, also known as ‘mitoepigenetics’ is an intriguing regulatory mechanism in mitochondrial DNA (mtDNA)-encoded gene expression. In this review, we summarized the recent advances in mitoepigenetics, with a special focus on mtDNA methylation in reproductive biology and preimplantation development. A better comprehension of the regulatory role of mitoepigenetics will help the understanding of mitochondrial dysfunction and provide novel strategies for in vitro production systems and assisted reproduction technologies, as well as prevent metabolic related stress and diseases.
Un modo de resistir al biopoder: El lugar de la parrhesia en las reflexiones ético políticas de Michel Focault
Authors: Cadahia L. 
Published: May 2023

La propuesta del presente artículo versa sobre la posibilidad de pensar la importancia del vínculo entre los conceptos de libertad y parrhesia dentro del proyecto filosófico de Michel Foucault. Para llevar a cabo esta tarea vamos a mostrar, por un lado, de qué manera emerge el problema de la libertad en los escritos foucaultianos. Estudiaremos que el giro suscitado entre el primero y el segundo momento del proyecto del filósofo plantea una vía que, a la vez que resuelve ciertas tensiones de los primeros análisis de la noción de poder, también abre un espacio de inteligibilidad para pensar de otra manera el vínculo entre libertad y poder. Asimismo, mostraremos en qué medida la noción de parrhesia abre un espacio para trabajar el problema de la libertad y su vínculo con la ética y la política. Finalmente, la propuesta consiste en bosquejar cómo el concepto de la parrhesia, en los términos de un decir franco, emerge como un ejercicio de resistencia al biopoder.
The Problem of Human Rights in Direct Democracy
Authors: KRZYWOSZYNSKI Przemyslaw 
Published: May 2023

El objetivo principal de este artículo es ilustrar la relación entre los derechos humanos y los referendos. En la teoría del derecho internacional y constitucional, los derechos humanos son considerados fundamentales. Un Estado democrático moderno debe garantizar la protección de los derechos humanos como la dignidad, la libertad y la propiedad de los bienes, así como garantizar la igualdad y los derechos sociales y económicos. Sin embargo, desde sus inicios, los fundamentos de estos derechos han sido asociados con el conflicto y en épocas como la Revolución francesa y el tiempo de terror, en situaciones como dictaduras y sistemas totalitarios a menudo se abusa de términos tomados del vocabulario de los derechos humanos, entre ellos la libertad e igualdad.
Como la institución más básica de la democracia directa moderna, el referéndum parece ser un excelente medio de protección de los derechos humanos. Sin embargo, los referendos también ofrecen oportunidades para limitar estos derechos, y no sólo por parte de regímenes totalitarios y autoritarios que buscan utilizar esta institución para legitimar su poder. En las democracias, cuando se pregunta acerca de un tema muy difícil (por ejemplo, un problema moral) a menudo son impulsados por emociones durante las campañas y la hora de votar. En relación con los derechos humanos, los referendos por lo tanto puede ser un arma de doble filo.
As the most basic institution of modern direct democracy, the referendum would seem to be an excellent means of protecting human rights. However, referendums also provide opportunities for limiting these rights, and not only by totalitarian and authoritarian regimes seeking use this institution to legitimize their power. In democracies, when people are asked about a very difficult subject (e.g. a moral problem) they are often driven by emotions during the campaigns and when voting. In relation to human rights, referendums can thus be a double-edged sword.
Hydrodynamic normalization conditions in the theory of degenerate Beltrami equations
Authors: Gutlyanskiĭ V.Ya. , Ryazanov V.I. , Sevost’yanov E.A. , Yakubov E. 
Published: May 2023

We study the existence of normalized homeomorphic solutions for the degenerate Beltrami equation fz = μ(z )f in the whole complex plane C , assuming that its measurable coefficient μ(z ), | μ(z ) |<1 a. e., has compact support and the degeneration of the equation is controlled by the tangential dilatation quotient KT μ (z , z0) . We show that if KT μ (z , z0) has bounded or finite mean oscillation dominants, or satisfies the Lehto type integral divergence condition, then the Beltrami equation admits a regular homeomorphic W1,1loc solution f with the hydrodynamic normalization at infinity. We also give integral criteria of Calderon-Zygmund or Orlicz types for the existence of the normalized solutions in terms of KT μ (z , z0) and the maximal dilatation Kμ (z ) .
A catequese católica: caminhos da secularização ou da abertura?
Authors: Diniz Lira André Augusto , Adam Júlio Cézar 
Published: May 2023

No século XX, foram muitas as mudanças ocorridas na Igreja Católica Apostólica Romana (ICAR) na liturgia, no entendimento de questões contemporâneas, na evangelização e na catequese, entre outras. Essas se processaram sob alegações contrapostas nas quais figura a disputa sobre a interpretação legítima da ortodoxia católica. Este artigo apresenta, inicialmente, esses posicionamentos em disputa, vinculando a catequese à secularização ou à abertura da ICAR; considera, a seguir, uma análise mais atual dos limites desse tipo de abordagem da secularização; e, finalmente, debruça-se sobre os três últimos Diretórios para a catequese [Diretório Catequístico Geral (1971), Diretório Geral para a Catequese (1997), do Diretório para a Catequese(2020)], procurando nesses o movimento de constituição oficial da ICAR.
Severe Neonatal Skin Infection: Clinical Case
Authors: Efimov Denis K. , Goncharova Ekaterina A. , Khachaturyan Maria A. , Turti Tatyana V. , Makarova Lyudmila M. 
Published: May 2023

Background. Pyoderma is the most common skin infectious disease of early age, it is a group of dermatoses characterized by purulent-inflammatory damage to the skin, dermal appendages, and subcutaneous fat. The diagnosis is based on medical history and physical examination. The main treatment methods are antibacterial therapy (local or systemic) and antiseptic skin toilet. Some forms of deep pyoderma require surgical interventions.Clinical case description. Girl A., 14 days of life, was admitted to the neonatal department of infectious disease with complaints of the mass in the left shoulder joint area. Historical information: 27 years old mother was not observed in any maternity welfare centre; chorioamnionitis was revealed at admission to the obstetric hospital. She received broad-spectrum antibacterial therapy perinatally. A girl from spontaneous vaginal delivery born on the 39th week with body weight of 2700 g, body length of 50 cm, and APGAR score of 8/9, she was breastfed. The condition on admission was severe. There were multiple indurated rash elements (pustules with turbid fluid) on the skin of the chest, limbs, and back. Skin desquamation was noted. There was hyperemia area up to 3.5 × 1.5 cm in the left shoulder joint area, with soft-elastic consistency, fluctuation symptom was positive. Complete blood count has shown: leukocytosis and neutrophilosis. Methicillin-resistant Staphylococcus aureus (MRSA) was revealed in blood via PCR method, in hemoculture, and in throat and nose cultures. C-reactive protein level was increased. Abscess culture — MRSA. Screening by immunological assay was performed to exclude primary immunodeficiency. Abscess incision and drainage were performed; 5 mL of thick yellow-green pus was obtained. Combination therapy with broad-spectrum antibiotic was carried out.Conclusion. There was positive dynamics on the administered therapy: the child condition was satisfactory, skin cleared of infectious rash, abscess was sanitized, laboratory parameters normalized, the child had no fever.
Linguistic accuracy and authenticity of the content of the Russian version of the module of gastrointestinal symptoms of the PedsQL<sup>™</sup> questionnaire for pediatric patients
Authors: Arakelyan Anna L. , Surkov Andrey N. , Baranov Aleksander A. , Namazova-Baranova Leyla S. , Gorev Valeri V. , Moskvina Elena B. , Skvorcova Tamara A. , Nikitin Artem V. , Chernikov Vladislav V. 
Published: May 2023

Background. Health Related Quality of Life (HRQL) is a person’s perception of the effect of a disease on physical, social and psychological functioning and wealth. Questionnaires that help assess the HRQL can give a concept of child’s state, identify arcane issues and they are of great importance for a full understanding of how the state of health affects the child. Universal HRQL tools allow to compare results with general parameters, indicators with specific symptoms better reflect clinically significant moments. The most widespread in the Russian Federation was the general PedsQLTM 4.0 questionnaire, widely used in practice to assess HRQL in children with various pathologies. Objective.The aim of the study is to describe the analysis of linguistic accuracy and authenticity of the content of the Russian version of the module of gastrointestinal symptoms of the PedsQLTM questionnaire, measuring HRQL, in children with gastrointestinal disorders (GIDs).Materials and methods. The establishment of linguistic accuracy and authenticity of the content was carried out according to international standards. The process included forward translation, scientific assessment and coordination, reverse translation, verification of the reverse translation and interviews with 17 children aged 5–18 years with symptoms of GIDs and 20 parents of children with symptoms of GIDs aged 2–18 years.Results. The Russian version of PedsQLTM module of gastrointestinal symptoms (report from children 5-18 years old, report from parents for children 2–18 years old) was developed without significant difficulties. Eight questions required discussion after the forward translation, one change was made after the reverse translation, and three changes were made after the study of the symptom’s module by patients and parents.Conclusion. A conceptually equivalent version of the of PedsQLTM module of gastrointestinal symptoms in Russian has been developed for children aged 2–18 years. It allows to improve the assessment of HRQL in children with GIDs in the Russian Federation. To assess authenticity and reliability of the Russian version of the module, it’s recommended to conduct further research using a larger sample