bluuebunny/crossref_metadata_2025_split huggingface dataset:
Seni Musik Sebagai Pendekatan Pembelajaran Berbasis Budaya di Sekolah Dasar
Authors: Loustiawaty Lousy , Fitriyani Yani , Andri Nur Patrio  
Published: January 2025

Kesenian musik merupakan salah satu kekayaan budaya dalam masyarakat, seni berperan dalam pemenuhan kebutuhan dasar pendidikan manusia seperti untuk memenuhi kebutuhan dasar estetika, pengembangan sikap dan kepribadian dan sebagai determinan terhadap kecerdasan. Penelitian ini bertujuan untuk ini mengkaji penggunaan seni musik sebagai pendekatan pembelajaran dalam pembelajaran seni musik di sekolah dasar. Penelitian ini menggunakan pendekatan kualitatif. Metode yang digunakan adalah deskriptif bertujuan untuk mengamati dan menganalisis serta menggambarkan pentas seni sebagai pendekatan pembelajaran dalam pendidikan seni musik. Subjek penelitian ini adalah peserta didik sekolah dasar kelas III. Hasil penelitian menunjukan bahwa seni musik dapat meningkatkan keterlibatan peserta didik, memfasilitasi pemahaman konsep yang lebih mendalam, dan memperkaya pengalaman belajar secara keseluruhan. Melalui pendekatan interdisipliner yang menggabungkan teori pendidikan, psikologi, dan seni. Penelitian ini menunjukkan bahwa integrasi musik dalam proses pembelajaran tidak hanya meningkatkan motivasi dan partisipasi peserta didik untuk belajar, tetapi juga mengembangkan keterampilan kognitif dan sosial mereka. Hasil penelitian ini diharapkan dapat memberikan wawasan baru bagi pendidik dan praktisi untuk mengadopsi metode pembelajaran yang lebih kreatif dan efektif.
Lipid metabolism indicators provide tools for the diagnosis of non-alcoholic fatty liver disease: results of a nationwide survey
Authors: Wang Yongxin , Fu Chang , Jin Hengwei , Yang Yibo , Li Xiaocong , Liu Kai 
Published: January 2025

BackgroundCardiometabolic index (CMI), visceral adiposity index (VAI), and lipid accumulation product (LAP) are lipid-related parameters that reflect central obesity, which is closely associated with the development of non-alcoholic fatty liver disease (NAFLD). The aim of this study is to investigate the effectiveness of these lipid-related parameters in diagnosing NAFLD and to compare their predictive abilities.MethodsThis population-based study extracted datasets from the National Health and Nutrition Examination Survey (NHANES) 2017–2020. CMI, VAI, and LAP were included in the multivariate logistic model as both continuous and categorical variables to assess the relationship between different lipid-related parameters and NAFLD. To further elucidate this connection, we utilized restricted cubic splines and conducted subgroup analysis. Additionally, the receiver operating characteristics (ROC) curve was employed to evaluate the predictive effectiveness of CMI, VAI, and LAP for NAFLD.ResultsThe study included 2,878 adults as the study population, of whom 1,263 participants were diagnosed with NAFLD. When lipid-related parameters were analyzed as continuous variables, they showed a positive correlation with NAFLD. The OR(95%CI) were 2.29(1.81,2.89) for CMI (per 1-unit), 1.40(1.28,1.52) for VAI (per 1-unit) and 1.15(1.11,1.20) for LAP (per 10-units). This correlation remains statistically significant when the lipid-related parameters are analyzed as categorical variables. In descending order of diagnostic capability for NAFLD, the AUC values are as follows: LAP (0.794), CMI (0.752), and VAI (0.719).ConclusionCMI, VAI, and LAP may be important clinical indicators for identifying NAFLD, with LAP demonstrating the best predictive ability among them.
Genomic deletions on 16p11.2 associated with severe obesity in Brazil
Authors: da Silva Assis Izadora Sthephanie , Salum Kaio Cezar Rodrigues , Felício Rafaela de Freitas Martins , Palhinha Lohanna , de Medeiros Abreu Gabriella , Silva Tamara , Mattos Fernanda Cristina Carvalho , Rosado Eliane Lopes , Zembrzuski Verônica Marques , Campos Junior Mario , Maya-Monteiro Clarissa Menezes , Cabello Pedro Hernán , Carneiro João Regis Ivar , Bozza Patrícia Torres , da Fonseca Ana Carolina Proença 
Published: January 2025

IntroductionGenetic obesity is considered a rare disease, affecting up to 10% of patients with severe early-onset obesity. Over the past years, significant advances have been made; however, the majority of patients are misdiagnosed with polygenic obesity. Thus, this study aimed to identify deleterious copy number variations (CNVs) linked to obesity and explore the clinical phenotypes.MethodThe sample comprised 195 adults with severe obesity (BMI≥35kg/m2) who developed this phenotype during childhood or adolescence. We investigated the CNV using Multiplex Ligation-dependent Probe Amplification [MLPA] and real-time PCR. Chromosomal microarray analysis was used to assess the extent of genomic alterations.ResultsOne patient showed a ~206 kb deletion in the distal of the 16p11.2 region, encompassing twelve genes. The gene linked to the development of severe obesity was SH2B1. This alteration was found in a male patient with metabolic syndrome (MS), and hypertension. Two patients exhibited a large deletion in the proximal of the 16p11.2 region. One patient showed a ~534 kb deletion without twenty-nine genes. This female patient had hypertension and bronchitis. The other patient presented a ~598 kb deletion of the proximal 16p11.2 region, including thirty-two genes. This female patient exhibited MS, and moderate binge-eating disorder.ConclusionOur study showed three genomic deletions at the 16p11.2 region in patients with severe obesity from Brazil. These results support the clinical utility of genetic testing to identify patients with the genetic form of obesity who may benefit from specific medical treatment, family genetic counseling, and targeted therapeutic intervention.
Evaluating the influence of anti-PD-1 immunotherapy combined with IMRT on thyroid dysfunction in nasopharyngeal carcinoma
Authors: Chen Liqianqi , Li Zihuang , Li Xianming , Wu Shihai , Gong Long , Xu Gang , Chen Shanyi , Zhang Yucong 
Published: January 2025

BackgroundImmunotherapy represents a major breakthrough in malignant tumor treatment in recent years. Anti-PD-1 immunotherapy has significantly prolonged Event-free Survival (EFS) in Nasopharyngeal Carcinoma (NPC). However, its potent anti-tumor effects can also attack normal tissues and organs, leading to immune-related adverse effects (irAE), with the thyroid being one of the most commonly affected organs. This study aims to analyze the incidence and related factors of thyroid dysfunction in NPC patients receiving anti-PD-1 immunotherapy with/without Intensity-modulated radiotherapy (IMRT), and further explore whether radiotherapy interacts with thyroid immune-related adverse reactions.Methods108 NPC patients receiving immunotherapy combined with chemotherapy or chemoradiotherapy were retrospectively included. Data collected included smoking status, BMI, presence of thyroid nodules, staging, treatment modality, thyroid mean dose (Dmean), percentage of thyroid volume receiving more than x Gy, pituitary mean dose (Dmean), and TSH and FT4 levels per cycle. T-tests, rank-sum tests, multivariate logistic regression analysis, ROC curves, and Cox proportional hazards models were used to evaluate the effects of anti-PD-1 immunotherapy combined with chemoradiotherapy on thyroid function.ResultsPatients with pre-treatment smoking history, thyroid nodules, and cervical lymph node metastasis were more likely to develop thyroid dysfunction (P&lt;0.05). During treatment, 81 patients developed varying degrees of thyroid dysfunction. Subclinical hyperthyroidism (33.9%) was most common in the immunotherapy plus chemoradiotherapy group, while subclinical hypothyroidism (23.9%) was most common in the immunotherapy plus chemotherapy group. Compared to the immunotherapy plus chemotherapy group, the immunotherapy plus chemoradiotherapy group showed higher incidence and severity of hyperthyroidism (median peak FT4 concentration: 19.11 pmol/L vs 16.21 pmol/L) (P=0.001). The immunotherapy plus chemoradiotherapy group showed lower incidence but increased severity of hypothyroidism compared to the immunotherapy plus chemotherapy group, though these differences were not statistically significant.ConclusionNPC patients with smoking history, thyroid nodules, and cervical lymph node metastasis have significantly increased risk of thyroid dysfunction when receiving anti-PD-1 immunotherapy combined with IMRT. The combination of anti-PD-1 immunotherapy and IMRT increases both the incidence and severity of thyroid dysfunction.
Severe Guillain-Barré syndrome with concurrent optic neuritis in a pediatric patient: a case report
Authors: Xue Xin , Bao Yingcun , Yu Yakun , Li Qun , Liu Mei , Li Xiaoling 
Published: January 2025

IntroductionGuillain-Barré syndrome (GBS) is a rare, immune-mediated polyneuropathy primarily affecting the peripheral nervous system. Diagnosis is often supported by neuroconduction studies showing polyradiculoneuropathy and cerebrospinal fluid (CSF) analysis revealing albumin-cytological dissociation. However, these features may not appear in the early stages, leading to potential misdiagnosis. The central nervous system (CNS) is generally not affected due to differences in antigen expression, optic neuritis (ON), a demyelinating inflammation of the optic nerve, occasionally co-occurs with GBS as a rare variant. Although GBS can manifest with various neurological symptoms, the co-occurrence of optic neuritis (ON) is rare, especially in pediatric cases. This report documents the first known case in China of a child with severe GBS complicated by ON, which developed following an upper respiratory infection.Case presentationA 14-year-old male presented with acute progressive quadriparesis and visual impairment following a febrile illness. On admission, he displayed severe respiratory and autonomic instability requiring mechanical ventilation. Neurological examination revealed flaccid paralysis of all four limbs with absent reflexes, along with bilateral optic neuritis, confirmed by MRI showing inflammation of the optic nerve. Initial cerebrospinal fluid (CSF) analysis was normal, but subsequent testing revealed elevated protein levels typical of GBS. Neurophysiological studies indicated widespread demyelinating and axonal damage.Interventions and outcomesThe patient received intravenous immunoglobulin (IVIG) therapy, high-dose corticosteroids, and, given the severe progression, rituximab. Despite initial worsening, gradual improvement in muscle strength and visual acuity was observed over several weeks. At three months, the patient was discharged with significantly restored function, with muscle strength nearing baseline and partial visual recovery.ConclusionThis case highlights the clinical complexity of GBS with ON in pediatric patients, emphasizing the importance of timely immunomodulatory treatment. It also underscores the need for awareness of overlapping central and peripheral autoimmune neuropathies to improve diagnostic accuracy and patient outcomes.
Antibodies against neuronal surface antigens in acute stroke: a systematic review and meta-analysis
Authors: Paolucci Matteo , Zini Andrea , Morelli Luana , Liguori Rocco , Giannoccaro Maria Pia 
Published: January 2025

BackgroundAntibodies against neuronal surface antigens (NSA-Abs), particularly against the NMDA receptor (NMDAR-Ab), have been reported in acute stroke patients (ASP). However, their role in stroke is far from being understood.MethodsWe conducted a systematic review and meta-analysis to investigate: 1) the frequency of NSA-Abs in patients with acute stroke compared to controls; 2) the de novo appearance of NSA-Abs after stroke; and 3) their effects on the clinical outcome.ResultsWe included nine studies in the qualitative analysis and seven in the quantitative analysis. Analyses were restricted to NMDAR-Abs due to the lack of data about other NSA-Abs. Considering only studies that adopted a cell-based assay, IgA-IgM NMDAR-Abs isotypes (but not the IgG) were found more frequently in patients with acute stroke (OR 2.69, 95% CI 2.00–3.62, I2 = 4%). There was no de novo NMDAR-Abs formation after stroke. There was no statistical difference in mean discharge/day–7 NIHSS (SMD 0.21, 95% CI -1.10–1.52, I2 = 84%) and 3–12-month mRS (SMD 0.38, 95% CI -0.56-1.32, I2 = 78%) between patients with stroke with and without NMDAR-Abs seropositivity.ConclusionsSerum IgA/IgM NMDAR-Abs are more frequent in patients with stroke than controls. Due to several methodological issues, these findings should be interpreted cautiously. Additional, methodologically robust studies are needed to clarify the prevalence and significance of NMDAR-Abs in patients with stroke.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42022241278#:~:text=https%3A//www.crd.york.ac.uk/prospero/display_record.php%3FID%3DCRD42022241278, identifier CRD42022241278.
Orbital cycle records in shallow unconsolidated sediments: implications for global carbon cycle and hydrate system evolution in deep-sea area sediments of the Qiongdongnan Basin
Authors: Dong Yang , Wang Ren , Liang Jinqiang , He Yulin , Ren Jinfeng , Shi Wanzhong , Wei Xiaosong , Du Hao , Xie Xiangyang , Busbey Arthur B. 
Published: January 2025

IntroductionMilankovitch theory has extensive application in sequence stratigraphy and the establishment of time scales. However, it is rarely applied to shallow strata rich in hydrates. Cyclostratigraphic analysis of the Quaternary unconsolidated sediments can help identify climate and sea level changes that correspond to orbital cycles and improve our understanding of the dynamic evolution of hydrates.MethodsUsing the natural gamma-ray log data from the deepwater area well W01 in the Qiongdongnan Basin, Milankovitch cycle analysis was conducted to identify the primary astronomical period in W01. Anchored to existing AMS-14 C age from bivalve shell as reference point, an astronomical age scale of W01 was established. Simultaneously, through the analyses of major trace elements and total organic carbon content (TOC) in sediment samples, how astronomical orbital cycles influenced past environmental conditions. Furthermore, employing sedimentary noise models, the relative sea level change of well W01 was reconstructed.ResultsSedimentary cycles of 27.34 m and 6.73 m were identified in the GR data from well W01, corresponding to orbital periods of 405 kyr and 100 kyr eccentricity, with a duration of approximately 2.5 Myr. The spectral analysis of paleoenvironmental proxies reveals a sedimentary cycle of approximately 27 m, while the sedimentary noise model reconstructs the fluctuating rise in sea level change. An obliquity modulation period of approximately 170 kyr was identified in the TOC data, which may reflect the combined effects of obliquity and other orbital parameters.DiscussionSpectral analysis of paleoenvironmental indicators showed that long eccentricity cycle had varying degrees of influence on changes in paleoclimate, paleosalinity, and paleoredox conditions. Additionally, a 1.2 Myr cycle was identified as a significant factor influencing sea level changes during the early Pleistocene in the South China Sea (SCS). In addition, it is confirmed that the dominant period of the glacial-interglacial cycle in the SCS from 0.6 Ma to the present is 100 kyr period. Synthesize the above analysis, during phases of low amplitude in the 405 kyr cycle or minimum value of the 100 kyr cycle, which are associated with lower temperature, conditions become more conducive to hydrate accumulation.
Associations between systemic immune-inflammatory index and visceral adipose tissue area: results of a national survey
Authors: Liao Yayun , Zhou Kejian , Lin Baoquan , Deng Shan , Weng Baohui , Pan Liya 
Published: January 2025

BackgroundGlobal health issues related to obesity are growing. Visceral adipose tissue (VAT) significantly contributes to complications associated with obesity. Reducing adipose tissue accumulation can improves inflammation. However, it is still unknown how the systemic immune-inflammation index (SII) and VAT area are related.MethodsWith the help of multivariate linear regression and smooth curve fitting, the relationship between SII and VAT area was explored with data from the 2013 and 2014 National Health and Nutrition Examination Survey (NHANES). Analyzing subgroups and testing for interaction were used to investigate whether the relationship was accurate across demographics.ResultsFrom 20 to 59 years of age, 3,290 individuals were observed to have a positive correlation between SII and VAT area. In accordance with the fully adjusted model, the VAT area increased by 9.34 cm2 for every unit increase in log SII [β = 9.34, 95% CI (4.02, 14.67)]. In the highest quartile of SII, the VAT area was 5.46 cm2 [β = 5.46, 95% CI (2.21, 8.71)] higher than that in the lowest quartile. Additionally, the population that was overweight or obese showed a stronger positive correlation.ConclusionSII has a positive correlation with VAT area in US adults. SII may be valuable in clinical applications to evaluate the severity of VAT area.
Perfil discente do Curso Jardins Amigos da Fauna, Escola Municipal de Jardinagem, Prefeitura do Município de São Paulo
Authors: Silva Linda Lacerda da , Brischi Ana Maria , Beloni Thiago , Lacerda Luciene L. , Roncatti Nicolle W 
Published: January 2025

O curso Jardins Amigos da Fauna foi criado em 2018, na Escola Municipal de Jardinagem, da Prefeitura do Município de São Paulo, para ensinar noções básicas de: morfologia floral, polinização, fecundação, morfologia e dispersão de frutos e sementes, nomenclatura biológica, plantio e paisagismo, visando abrigar e alimentar a fauna silvestre do Município de São Paulo, auxiliar na escolha da espécie vegetal, enfatizando-se plantas nativas. Os objetivos foram os de ensinar, sensibilizar, criar agentes multiplicadores e conhecer o perfil dos alunos para o aprimoramento do curso. Ministraram-se aulas teóricas e práticas. Grande parte dos alunos era novata (67,57%), de faixa etária ampla, de 19 a 60 anos, sendo que a maioria era do sexo feminino (72,33%) e vindos da zona Sul (33,33%). A maioria dos alunos (23) respondeu que escolheu fazer o curso por razões pessoais. Estes resultados correspondem com aqueles encontrados na literatura, em cursos de paisagismo, nos quais há um número maior de mulheres participantes, com ampla faixa etária, e as motivações para fazer o curso são, predominantemente, pessoais.
Clima organizacional y satisfacción laboral en el distrito educativo de Santa Elena
Authors: Domínguez Ruiz Ximena Alexandra , Guerrero Bejarano María Auxiliadora , Manosalvas Vaca Carlos Aníbal , Vaca López Gonzalo Ramón 
Published: January 2025

The general objective of this work was to analyze the impact of the environment within companies on the sense of well-being of the administrative officials of the Santa Elena Educational District. It was theoretically based, with a basic, quantitative approach in which the survey was used as the main technique for collecting information using the questionnaires of Paúl Spector (1985) to measure satisfaction and that of Litwin and Stringer (1968) to measure the organizational climate; It had an adequate analysis to obtain the results in order to identify the impact that exists on the workers' sense of well-being and contribute internally to the improvement of processes in the institution. The specific hypotheses H3, H4, H5, H6, H7, H8 were accepted, except for H2, which is rejected as this dimension has no impact, which causes the general hypothesis H1 to be partially accepted. The results obtained show how the variables are related, although with variations in the influence of their different dimensions, which encourages the creation of improvement strategies within the Santa Elena Educational District to improve the organizational environment of the institution to thus positively affecting the sense of well-being of workers for the benefit of students.
PENGELOMPOKAN TEKANAN DARAH LANSIA DENGAN ALGORITMA K-MEANS DI KP.LEBAK JERO
Authors: Elsa Safutri  , Purnamasari Ade Irma , Bahtiar Agus , Wahyudin Edi 
Published: January 2025

Hipertensi merupakan salah satu masalah kesehatan utama yang sering dialami oleh lansia dan memerlukan penanganan yang tepat. Namun, keterbatasan sumber daya di Posbindu sering kali menjadi hambatan dalam mengidentifikasi kelompok risiko hipertensi secara efektif. Penelitian ini bertujuan untuk merancang model pengelompokan risiko hipertensi pada lansia di Posbindu Kp. Lebak Jero menggunakan algoritma k-means, dalam mendukung intervensi kesehatan yang lebih terarah. Data yang dianalisis mencakup tekanan darah sistolik, diastolik, usia, jenis kelamin, dan berat badan, berdasarkan catatan Posbindu selama bulan Agustus-September 2024. Proses analisis dilakukan melalui tahapan Knowledge Discovery in Database (KDD), yang meliputi pengumpulan, pra-pemrosesan, transformasi data, pengelompokan, dan evaluasi. Untuk mengevaluasi kualitas hasil pengelompokan, digunakan Davies-Bouldin Index (DBI). Hasil penelitian menunjukkan bahwa DBI optimal sebesar 0,881 dengan k=2. Cluster pertama (Cluster_0) terdiri dari 75 lansia berisiko rendah (19 orang dengan tekanan darah normal dan 56 orang pra-hipertensi), dengan rentang usia 45-59 tahun (46 orang), 60-69 tahun (22 orang), dan >70 tahun (7 orang). Cluster kedua (Cluster_1) terdiri dari 71 lansia berisiko tinggi (28 orang hipertensi tingkat 1 dan 43 orang hipertensi tingkat 2), dengan rentang usia 45-59 tahun (26 orang), 60-69 tahun (30 orang), dan >70 tahun (15 orang). Tekanan darah sistolik pada Cluster_0 berada pada kisaran 80-143 mmHg dan diastolik 80-90 mmHg, sementara pada Cluster_1 sistolik 140-200 mmHg dan diastolik 78-130 mmHg. Penelitian ini menunjukkan bahwa algoritma k-means mampu memetakan kelompok risiko hipertensi dan membantu pemantauan serta mendukung pelaksanaan intervensi kesehatan yang lebih efektif dan terarah di Posbindu Kp. Lebak Jero.