bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENGARUH K3 (KESELAMATAN DAN KESEHATAN KERJA) DAN LINGKUNGAN KERJA TERHADAP KINERJA KARYAWAN DI PT. SAIPEM INDONESIA KARIMUN YARD
Authors: Zhaflesia Zhetta Zhahiriyah , Dewi Aditya Mutiara , Febri Anti Rekha Dea 
Published: February 2025

Tujuan penelitian ini adalah untuk mengetahui pengaruh K3 (Keselamatan dan Kesehatan Kerja) dan lingkungan kerja terhadap kinerja karyawan yang ada di PT. Saipem Indonesia Karimun Yard. Populasi dalam penelitian adalah karyawan yang ada di PT. Saipem Indonesia Karimun Yard. Respoden dalam penelitian ini sebanyak 100 orang. Pengambilan sampel dilakukan dengan menggunakan teknik purposive sampling. Pengumpulan data dilakukan dengan menggunakan data primer melalui kuesioner menggunakan skala likert untuk mengukur 16 pernyataan indikator.Teknik analisis data menggunakan metode kuantitatif, Pengolahan data menggunakan aplikasi SPSS 25.0. Analisis data menggunakan teknik analisis regresi linear, uji t, uji f. Hasil penelitian menunjukan bahwa pengaruh Keselamatan dan Kesehatan Kerja (K3) dan lingkungan kerja secara bersama-sama berpengaruh terhadap kinerja karyawan. Dari hasil pembahasan, dapat ditarik kesimpulan bahwa K3 (Keselamatan dan Kesehatan Kerja) dan lingkungan kerja di PT. Saipem Indonesia Karimun Yard bisa dikatakan baik, serta dapat dipertahankan untuk program dan usaha yang telah dilaksanakan.
Evaluating diabetes-related nutrition knowledge and dietary beliefs among type 2 diabetes patients in Vidarbha region, Maharashtra: a mixed method approach for insightful analysis
Authors: Kawalkar Umesh , Mankar Amar , Puri Mahesh , Singh Anshu , Telrandhe Shital , Gaidhane Abhay , Talapalliwar Manoj , Fuladi Sayali 
Published: February 2025

IntroductionThe purpose of this study is to evaluate diabetes-related nutrition knowledge and dietary beliefs among Type 2 Diabetes Mellitus (T2DM) patients in the Vidarbha region, Maharashtra, utilizing a mixed method approach. The study aims to assess the existing gaps in nutritional education and dietary practices among T2DM patients, with a specific focus on understanding gender-based differences in knowledge levels.MethodsA convergent parallel mixed method approach was employed at tertiary care hospital in Vidarbha region, over 18 months. Participants aged 30 years and above, diagnosed with T2DM for at least 6 months, were included. Quantitative data collection utilized structured questionnaires during interviews to assess socio-demographic characteristics and diabetes-related nutrition knowledge. Qualitative data collection involved in-depth interviews to explore participants’ perspectives on dietary beliefs and practices, ensuring ethical approval and informed consent.ResultsTotal 384 T2DM patients participated, revealing significant gender disparities in diabetes-related nutrition knowledge. Male participants exhibited higher awareness levels across various aspects of dietary recommendations. Quantitative analysis highlighted gender differences in knowledge regarding recommended fruit and vegetable intake, milk product consumption, types of fruits suitable for diabetics, inclusion of rice in diabetic diets, alcohol consumption, and recommended salt intake. Qualitative analysis identified key themes related to food choices, meal timing, portion control, dietary restrictions, and cultural influences.ConclusionThe study emphasizes gender-sensitive educational interventions to enhance diabetes-related nutrition knowledge and self-management practices among T2DM patients. Tailored interventions addressing gender-based knowledge gaps are crucial for improving diabetes management outcomes and overall health among T2DM patients in Vidarbha, Maharashtra.
The post-orchiectomy systemic inflammatory index is associated with tumor characteristics in clinical stage I germ cell tumors
Authors: Lesko Peter , Mego Michal 
Published: February 2025

BackgroundApproximately 25% to 30% of clinical stage I (CSI) germ cell cancer (GCT) patients will experience disease relapse after an orchiectomy. Adding adjuvant treatment will decrease the relapse rate but could lead to over-treatment. Prognostic biomarkers such as lymphovascular invasion (LVI) and/or embryonal carcinoma (EC) in non-seminoma (NSGCT) and rete testis invasion (RTI) and/or primary tumor size (PTS) in seminoma (SGCT) add limited value in treatment decision- making. The aim of this study is to assess the systemic inflammatory index (SII) and lactate-dehydrogenase (LDH) with clinicopathological findings along with their prognostic impact.MethodsThis is a retrospective study that included 159 diagnosed CSI GCT patients, who underwent active surveillance (AS) from June 2004 to November 2023. Medical records and pathology reports were collected retrospectively. Drawn blood must have been done less than 3 months after the orchiectomy had been done. For the survival analysis, we used dichotomized values of the studied biomarkers from “low” to “high” based on the median values.ResultsThe median follow-up time was 61 months (ranging from 1 to 230 months), with 2-year relapse- free survival (RFS) of 81.3% and 69.0% in SGCT and NSGCT, respectively. We confirm inferior RFS in the presence of LVI compared to an absence of LVI in NSGCT ([HR]= 2.59, 95%CI (0.74-9.07), p=0.04). A trend of inferior RFS in NSGCT patients with EC predominance (≥50%) was also observed ([HR]= 2.59, 95%CI (0.98-6.85), p=0.06). A prognostic impact of RTI and a PTS &gt;4cm in SGCT was not observed with p=0.24 and p=0.51, respectively. The SII was assessed in the population, and a higher neutrophil- to- lymphocyte ratio (NLR) value was associated with LVI presence and with advanced tumor stage in NSGCT. In SGCT, a higher SII level was associated with LVI presence and advanced pathological stage. A PTS &gt;4cm was associated with a higher LDH level among all the studied patients, without significance in SGCT or NSGCT. A higher LDH value in NSGCT was also associated with EC predominance (≥50%).ConclusionOur study, for the first time, revealed associations of post-orchiectomy systemic inflammatory indices and/or LDH in CSI GCT. These new associations deserve further evaluation in a larger cohort of patients with CSI GCT to elucidate whether its associations in certain histology subgroups will improve the stratification of the at-risk population.
Association between human leukocyte antigen E expression and outcomes in solid tumors: a systematic review and meta-analysis
Authors: Benitez Fuentes Javier David , Bartolome Arcilla Jorge , Lazaro Sanchez Antonio David , de Luna Aguilar Alicia , Mohamed Mohamed Kauzar , Guevara-Hoyer Kissy , Ballestin Martinez Pablo , Borregon Rivilla Miguel , Ferrandez Arias Asia , Sánchez-Ramon Silvia , Ocaña Alberto 
Published: February 2025

BackgroundImmunotherapy has gained momentum with the discovery of novel antibodies targeting immunosuppressive proteins. HLA-E, a non-classical major histocompatibility complex class I (MHC-I) protein, exhibits immunosuppressive properties, potentially influencing tumor immune evasion mechanisms. The association between Human Leukocyte Antigen E (HLA-E) expression and outcomes in solid tumors remains unclear.MethodsA systematic review of MEDLINE, Scopus, and the Cochrane Library up to March 15, 2024, was conducted following the PRISMA guidelines. Studies investigating HLA-E expression in solid tumors and its association with OS and DFS were included. Statistical analysis was performed using Comprehensive Meta-Analysis (version 3.0) with random-effects models.ResultsAfter screening 657 articles, 11 studies were included, comprising a total of 1781 patients. The studies encompassed a variety of cancer types, follow-up periods, and staging details, with the majority focusing on non-metastatic cases. Notably, three studies evaluated colorectal cancer, while others focused on pancreatic, esophageal, brain, renal cell, gastric, endometrial, cervical, and hepatocellular carcinomas. The mean age of the patients was 59.81 ± 2.01 years, and the median follow-up period was 57.45 ± 8.91 months. HLA-E expression demonstrated no statistically significant association with OS (HR 0.913, 95% CI = 0.567-1.469; P=0.707), with significant heterogeneity observed (I2 = 84%). However, HLA-E non-expression was significantly associated with improved DFS (HR 1.406, 95% CI = 1.027-1.930; P=0.03), with moderate heterogeneity (I2 = 45%).ConclusionThis systematic review highlights that HLA-E expression in solid tumors could be a biomarker of better prognosis, measured by DFS. These findings align with the clinical benefit observed for agents targeting this pathway. However, further studies should be performed to confirm these preliminary observations.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42024527598, identifier CRD42024527598.
Efficacy and prognostic impact of preoperative risk factors for salvage liver transplantation and repeat hepatectomy in patients with early-stage recurrent hepatocellular carcinoma: a propensity score-matched analysis
Authors: Yang Linfeng , Huang Yang , Deng Dawei , Liu Junning , Xu Liangliang , Yi Pengsheng 
Published: February 2025

BackgroundThe optimal treatment strategy for recurrent hepatocellular carcinoma (rHCC) remains unclear. This study is based on cases of rHCC after liver resection, aiming to evaluate the influence of preoperative risk factors on the long-term prognosis of patients with rHCC by comparing patients who underwent salvage liver transplantation (SLT) with those who underwent repeat hepatectomy (RH).MethodsWe retrospectively analyzed 401 consecutive patients with rHCC who underwent SLT or RH between March 2015 and December 2022. Next, we performed propensity score matching, subgroup analyses, and both univariate and multivariate analyses. In addition, Kaplan–Meier analysis was used to estimate the overall survival (OS) and recurrence-free survival (RFS) after recurrence.ResultsThe 1-, 3-, and 5-year OS and RFS rates in the SLT group were significantly higher than those in the RH group (p=0.0131 and p=0.0010, respectively), and similar results were observed after propensity score matching. In the presence of zero or one risk factors, the OS and RFS in the SLT group were significantly better than those in the RH group (p=0.0386 and p=0.0117, respectively). However, in the presence of two to four risk factors, no significant differences in OS or RFS were detected between the two groups (p=0.1119 and p=0.1035, respectively).ConclusionOur analysis identified a number of risk factors that were strongly correlated with a long term prognosis for patients with rHCC who underwent SLT and RH: multiple tumors, a maximum tumor diameter ≥5 cm, microvascular invasion, and a recurrence time ≤2 years. Our findings provide important reference guidelines for organ allocation and clinical decision-making.
Role of artificial intelligence in pediatric intensive care: a survey of healthcare staff perspectives in Saudi Arabia
Authors: Al-Sofyani Khouloud Abdulrhman 
Published: February 2025

BackgroundArtificial Intelligence (AI) has the potential to revolutionize Pediatric Intensive Care Units (PICUs) by enhancing diagnostic accuracy, improving patient outcomes, and streamlining routine tasks. However, integrating AI into PICU environments poses significant ethical and data privacy challenges, necessitating effective governance and robust regulatory frameworks to ensure safe and ethical implementation. This study aimed to explore valuable insights into healthcare professionals' current perceptions and readiness to adopt AI in pediatric critical care, highlighting the opportunities and challenges ahead.MethodsA cross-sectional study conducted an online survey among healthcare practitioners at King Abdulaziz University Hospital in Jeddah, Saudi Arabia. The survey included questions about professional roles, experience, and familiarity with AI, their opinions on AI's role, trust in AI-driven decisions, and ethical and privacy concerns. Statistical analyses were performed using IBM SPSS.ResultsResults found varying familiarity with AI among healthcare professionals, with many expressing limited knowledge of AI applications in PICU settings. Despite this, there was growing recognition of AI's current applications. Trust in AI-driven decisions for PICU management was mixed, with most expressing partial trust. Opinions on AI's role in enhancing diagnostic accuracy and improving patient outcomes varied. Ethical considerations, data privacy, and effective governance to address regulatory and ethical challenges were highlighted as critical concerns.ConclusionHealthcare practitioners in the PICU preferred using AI for routine patient monitoring but had concerns about its use in diagnoses and advanced healthcare. Concerns were held regarding data privacy, security breaches, and patient confidentiality.
Mechanical countermeasures for spaceflight-associated neuro-ocular syndrome during 30-days of head down tilt bed rest: design, implementation, and tolerability
Authors: Moestl Stefan , De Boni Laura , Hoenemann Jan-Niklas , Kramer Tilmann , Schmitz Jan , Pesta Dominik , Frett Timo , Bohmeier Maria , Frings-Meuthen Petra , Ewald Ann Charlotte , Nitsche Andrea , Loehr Patricia , Noppe Alexandra , Klischies Nicolas , Huang Alex S. , Laurie Steven S. , Marshall-Goebel Karina , Macias Brandon R. , Tank Jens , Jordan Jens , Mulder Edwin 
Published: February 2025

After longer duration space missions, some astronauts experience structural and functional changes in the eye and structural changes in the brain, termed Spaceflight-Associated Neuro-Ocular Syndrome (SANS). Countermeasures against SANS are required to minimize potential operation impacts and negative long-term health consequences. Headward fluid shifts, which appear to promote SANS, provide a target for countermeasures. The SANS countermeasures study, a 30 days strict head down tilt bed rest (HDTBR) study, tested two mechanical countermeasures aimed at reversing cephalad fluid overload. This work presents design and methodology of the study with a focus on countermeasure implementation and tolerability. Following baseline evaluations, participants were randomized to four groups and HDTBR commenced: Daily application of 25 mmHg lower body negative pressure for 6 h, six-hour bilateral venous constrictive thigh cuffs following moderate cycling exercise on 6 days per week, a negative control group without countermeasures, and a positive control group with HDTBR interruption for 6 h per day by sitting upright. The potential of these countermeasures for future space applications was examined in 86 different experiments, which will be reported elsewhere. Comfort ratings ranging from 1 (very uncomfortable) to 5 (very comfortable) were used to asses tolerability. Overall, 47 participants (20 women) completed the study. Out of 4,032 h scheduled for both countermeasures, 10.5 h were not performed due to medical issues unrelated to the countermeasures. Mean comfort ratings were 3.9 in men and 4.4 in women in the lower body negative pressure group (p = 0.1356) and 4.2 in men and 3.9 in women in the thigh cuff group (p = 0.1604). We conclude that both countermeasures were well tolerated and applied under well controlled conditions, thus, allowing for meaningful analyses of efficacy in attenuating HDTBR effects.
Determinants of suicidal behavior among elders in Northwest Ethiopia: implications for prevention
Authors: Siraj Seid , Belete Habte , Beka Michael , Shegaw Maregu , Belete Asmare , Birhan Zelalem 
Published: February 2025

BackgroundWorldwide suicide rates increases with age. Globally, suicidal behavior is a leading cause of injury and death. In many countries, older adult suicidal behavior is highly lethal because old people are unwilling to talk about their emotional problems and are less likely to report depression and suicidal thoughts. Exploring the phenomenon of suicide in the elderly in Ethiopia can provide a dependable source of reflection and add to the global aging, and suicide prevention conversation, generally in the low-income countries and middle-income countries (LMICs). This study aimed to assess the prevalence of suicidal behavior and its associated factors among elders in Bahir Dar city, Northwest Ethiopia.MethodA community-based cross-sectional study and multistage sampling technique were conducted among elders in Bahir Dar city. A systematic random sampling procedure was used to choose 626 elderly people over 65 years old in total who had lived in Bahir Dar city. Utilizing the revised Suicidal Behavior Questionnaire (SBQ-R), suicidal behavior was assessed. We quantify the related components using multivariable logistic regressions. The factors’ associations were delineated with odds ratios, 95% confidence intervals, and p-values that were deemed statistically significant at less than 0.05.ResultOverall, 12.8% (95% CI: 10.2, 15.3) of the population engaged in suicidal behaviors. The lifetime prevalence of suicidal ideation, plan, and attempts were 13.9%, 8.15%, and 1%, respectively. The prevalence of suicidal ideation in the past 12 months was 10.86%. The odds of being single (AOR: 2.19, 95% CI: 1.18, 4.06), having no social networks (AOR: 2.25, 95% CI: 1.01, 5.01), being depressed (AOR: 4.01, 95% CI: 1.97, 8.17), having a chronic illness (AOR: 3.03, 95% CI: 1.69, 5.44), and geriatric mistreatment (AOR: 7.81, 95% CI: 4.06, 15.05) were the independent predictors of suicidal behavior.ConclusionThe extent of suicidal behavior was found to be high in this study. The associated factors of suicide behavior include being unmarried, having a poor social network, having depression, chronic illness, and geriatric mistreatments. Therefore, clinicians should do routine mental health examinations for older persons, focusing on those who have a history of elder abuse or chronic illnesses, as these are major risk factors for suicide behavior. To detect and treat suicidal thoughts in elder populations, healthcare professionals should get culturally appropriate training. For legislators: create policies that address elder abuse by instituting community reporting mechanisms and legal protections for elder citizens, and give top priority to developing national healthcare initiatives that include elder-specific mental health and suicide prevention programs.
Prevalence of occupational injuries and associated factors among small scale industry Workers in Harar Town, eastern Ethiopia
Authors: Debelu Desi , Tolera Sina Temesgen , Baraki Negga , Mengistu Dechasa Adare 
Published: February 2025

BackgroundCurrently, small-scale industries pose significant risks for occupational injuries, particularly in developing countries, including Ethiopia. Despite this problem, there is limited evidence on the prevalence of occupation-related injuries in small-scale industries that can be utilized for proposing interventions. Therefore, this study aims to determine the prevalence of occupational injuries and associated factors among small-scale industry workers in Harar town, Ethiopia.MethodsA cross-sectional study employing a quantitative analysis was conducted in Harare town, Eastern Ethiopia, from March 12, 2023, to June 1, 2023. The source of population was all small-scale industry workers in Harar town, while the study population was workers working in selected small-scale industries. The sample size was determined based on the previous study finding reported 35.98% prevalence of occupational injuries. A simple random sampling method was employed to select the study participant, resulting in the inclusion of 639 participants in the study. Data were collected using pretested questionnaires and observational checklists, covering sociodemographic, occupational injuries, occupational health and safety practices, work environment, and behavioral related factors. The data were analyzed via SPSS version 22, and a p value of &lt;0.05 was considered the cut-off point for statistical significance in multivariate analysis.ResultsOut of the 639 small-scale industry workers included in the current study, 634 provided a response, resulting in a 99.2% response rate. Among these workers, 417 workers (65.8%) reported exposure to occupational injuries at least once in their careers, of which 223 (35.2%) were exposed to injuries in the last 12 months. The most commonly injured body parts were the hands (34.11%), legs (29.13%), and fingers (26.69%). The study found a significant associations between occupational injuries and type of industry (AOR: 2.41, 95% CI: 1.07, 5.46), educational status (AOR: 2.49, 95% CI: 1.01, 2.83), training (AOR: 1.4, 95% CI: 1.35, 3.22), working space (AOR: 4.6, 95% CI: 2.62, 7.51), and workload (AOR: 2.88, 95% CI: 2.78, 11.64).ConclusionMore than six out of 10 workers experienced injuries during their careers, with more than one-third being injured in the last 12 months. Workers with lower educational status, have no training, working in poor working conditions, and with higher workloads are at high risk of exposure. This highlights the need for improving occupational health and safety practices, including tailored training and supportive supervision to reduce injury in small-scale industries.Originality/valueThe findings from this study will be important for concerned bodies aiming to improve the occupational health and safety practices in small-scale industries and enhance the safe practices by addressing the safety culture in the working environment and policy making process.
Trends in Indicators of Violence Among Adolescents in Europe and North America 1994–2022
Authors: Molcho Michal , Walsh Sophie D. , King Nathan , Pickett William , Donnelly Peter D. , Cosma Alina , Elgar Frank J. , Ng Kwok , Augustine Lilly , Malinowska-Cieślik Marta , Bjereld Ylva , Craig Wendy 
Published: February 2025

ObjectivesTo describe age and gender specific time trends in adolescent violence across 19 countries over 28 years.MethodsThe paper presents analysis of eight cycles of the Health Behaviour in School-aged Children (HBSC) Study from 1994–2022, involving 789,531 children aged 11, 13, and 15. Indicators of violence included physical fighting, school bullying and cyberbullying (from 2018). Log-binomial regression models were used to test for linear temporal trends, with Generalized Estimating Equations used to account for clustering by country.ResultsSchool bullying perpetration and victimization declined over time in each age/gender group in most countries. Similar declines were reported for frequent physical fighting among boys (all ages) and girls (age 15 only). The prevalence of violent behaviour was almost universally higher in boys in the early cycles than in girls, but this gender difference attenuated over time. For cyberbullying, significant increases were observed since 2018 in all groups except age 15 girls in most countries.ConclusionThis analysis of a large cross-national dataset suggests a decline in traditional forms of adolescent violence. However, the increases in cyberbullying warrant further monitoring.