bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pre-stack seismic inversion for reservoir characterization in Pleistocene to Pliocene channels, Baltim gas field, Nile Delta, Egypt
Authors: El-Sayed Ali S. , Mabrouk Walid M. , Metwally Ahmed M. 
Published: January 2025

AbstractThe Nile Delta, North Africa’s leading gas-producing region, was the focus of this study aimed at delineating gas-bearing sandstone reservoirs from the Pleistocene to Pliocene formations using a combination of pre-stack inversion and rock physics analysis. This research employed seismic inversion techniques, including full-angle stack seismic volumes, well logs, and 3-D with rock physics modeling to refine volumes of P-wave velocity (Vp), S-wave velocity (Vs), and density. Traditional seismic attributes, such as far amplitude, proved insufficient for confirming gas presence, highlighting partial angle stacks, integrated the need for advanced methods. Extended Elastic Impedance (EEI) analysis was used to predict fluids and identify lithology in clastic reservoir environments. The EEI approach facilitated the determination of optimal projection angles for key petrophysical properties such as porosity, shale volume, and water saturation. This method was applied to the middle Pliocene (Kafr El Sheikh Formation) and the Pleistocene (El Wastani Formation), revealing promising drilling sites. In the Kafr El Sheikh Formation, porosity ranged from 16 to 29%, shale volume from 21 to 40%, and hydrocarbon saturation from 25 to 90%. The study concludes that integrating pre-stack seismic inversion with EEI significantly enhances the likelihood of identifying gas-bearing sands while reducing exploration risks. The improved POS for the Pleistocene anomaly gas bearing sand (from 49 to 69%) and the middle Pliocene anomaly (from 46 to 66%) underscores the effectiveness of this approach in the Baltim Field, Offshore Nile Delta, and supports further drilling and development wells.
Two-year follow-up of gait and postural control following initiation of recombinant human tripeptidyl intracerebroventricular enzyme replacement therapy in two atypical CLN2 patients
Authors: Soangra Rahul , Grant-Beuttler Marybeth , Chang Harriet , Wang Raymond Y. 
Published: January 2025

AbstractNeuronal ceroid lipofuscinosis type 2 (CLN2) is a rapidly progressive neurodegenerative disorder leading to premature mortality. Ambulatory CLN2 patients typically receive standard of care treatment through biweekly intracerebroventricular (ICV) enzyme replacement therapy (ERT) involving recombinant human tripeptidyl peptidase 1, known as cerliponase alfa (Brineura®, Biomarin Pharmaceuticals). This study longitudinally assessed the impact of ICV cerliponase alfa ERT on gait, and postural control across a two-year span in two siblings diagnosed with atypical CLN2 disease. Both participants, ID01 (18 years and 8 months old at enrollment) and ID02 (13 years and 3 months old at enrollment), exhibited symptomatic characteristics which were studied longitudinally over three years. Their evaluations assessed postural sway variability, potential for slips and trips, gait metrics, sit-to-stand durations, scores from the sensory organization test (SOT), and gross motor function measure (GMFM) scores. Findings indicated a decline in postural complexity and stability in the medial-lateral (ML) axis, a reduction in toe clearance, and an augmented risk of stumbling for the participants. Over the two-year period of ERT, both siblings exhibited a progressive decline in walking velocity, characterized by reductions in step length and prolonged gait cycle time. The elder sibling demonstrated a notable increase in double support duration, indicative of heightened reliance on proprioceptive input to maintain stability during ambulation. Additionally, sit-to-stand times lengthened for siblings, further reflecting declines in motor function. Despite these challenges, SOT scores showed improvement after two years of ERT, suggesting some preservation of sensory integration. These findings in SOT scores indicate that cerliponase alfa treatment in patients with atypical CLN2 disease may confer benefits in postural stability, lower extremity strength, and ankle stiffness. However, declines in more complex motor functions, including sit-to-stand performance and postural complexity, persist, underscoring the progressive nature of the disease despite ongoing therapeutic intervention.
Enhancing repeatability of follicle counting with deep learning reconstruction high-resolution MRI in PCOS patients
Authors: Yang Renjie , Zou Yujie , Li Liang , Liu Weiyin Vivian , Liu Changsheng , Wen Zhi , Zha Yunfei 
Published: January 2025

Abstract
Follicle count, a pivotal metric in the adjunct diagnosis of polycystic ovary syndrome (PCOS), is often underestimated when assessed via transvaginal ultrasonography compared to MRI. Nevertheless, the repeatability of follicle counting using traditional MR images is still compromised by motion artifacts or inadequate spatial resolution. In this prospective study involving 22 PCOS patients, we employed periodically rotated overlapping parallel lines with enhanced reconstruction (PROPELLER) and single-shot fast spin-echo (SSFSE) T2-weighted sequences to suppress motion artifacts in high-resolution ovarian MRI. Additionally, deep learning (DL) reconstruction was utilized to compensate noise in SSFSE imaging. We compared the performance of DL reconstruction SSFSE (SSFSE-DL) images with conventional reconstruction SSFSE (SSFSE-C) and PROPELLER images in follicle detection, employing qualitative indices (blurring artifacts, subjective noise, and conspicuity of follicles) and the repeatability of follicle number per ovary (FNPO) assessment. Despite similar subjective noise between SSFSE-DL and PROPELLER as assessed by one observer, SSFSE-DL images outperformed SSFSE-C and PROPELLER images across all three qualitative indices, resulting in enhanced repeatability in FNPO assessment. These results highlighted the potential of DL reconstruction high-resolution SSFSE imaging as a more dependable method for identifying polycystic ovary, thus facilitating more accurate diagnosis of PCOS in future clinical practices.
Antimicrobial susceptibility profiles of Mycoplasma hyosynoviae strains isolated from five European countries between 2018 and 2023
Authors: Klein Ulrich , Földi Dorottya , Nagy Eszter Zsófia , Tóth Lilla , Belecz Nikolett , Költő Karola , Wehmann Enikő , Marton Szilvia , Merenda Marianna , Gastaldelli Michele , Catania Salvatore , Spergser Joachim , Siesenop Ute , Vyt Philip , Bányai Krisztián , Kreizinger Zsuzsa , Depondt Wouter , Gyuranecz Miklós 
Published: January 2025

AbstractMycoplasma (M.) hyosynoviae is a facultative pathogen, causing arthritis in finisher pigs world-wide. In the absence of a commercial vaccine improvement of housing conditions and antibiotic therapy are the only options to alleviate the clinical signs. This study aimed to determine antibiotic susceptibility profiles of 106 M. hyosynoviae isolates against ten antibiotics licensed for veterinary use in cases of arthritis. The isolates were collected between 2018 and 2023 from five European countries: Austria (n = 20), Belgium (n = 20), Germany (n = 25), Hungary (n = 21) and Italy (n = 20). The minimal inhibitory concentrations (MIC) were determined by broth micro-dilution assay. The tested isolates were highly susceptible to tiamulin (MIC90 ≤ 0.039 µg/ml), tylvalosin (MIC90 ≤ 0.039 µg/ml) and lincomycin (MIC90 ≤ 0.25 µg/ml). Low concentrations of tylosin (MIC90 0.5 µg/ml) and tilmicosin (MIC90 1 µg/ml) inhibited the growth of the isolates. While moderate minimal inhibitory concentrations were detected for doxycycline (MIC90 0.312 µg/ml), oxytetracycline (MIC90 2 µg/ml), enrofloxacin (MIC90 0.625 µg/ml) and florfenicol (MIC90 2 µg/ml), only high concentrations of tulathromycin (MIC90 64 µg/ml) inhibited the growth of the isolates. Statistical analysis revealed significant differences between countries in case of enrofloxacin, where the Hungarian isolates showed the lowest MIC values, and the German isolates the highest MIC values among the tested countries. Our results show that European M. hyosynoviae isolates are generally susceptible to the tested antibiotics with the exception of tulathromycin. The country specific differences indicate the importance of regular susceptibility testing of isolates on a Pan-European level.
Site-designed dual-active-center catalysts for co-catalysis in advanced oxidation processes
Authors: Sun Wenxin , Liu Guoshuai , Zou Hua , Wang Shaobin , Duan Xiaoguang 
Published: January 2025

AbstractAdvanced Oxidation Processes (AOPs) are promising for treating persistent pollutants, yet challenges arise due to the step-wise oxidants activation process, which traditional single-active-center catalysts struggle to facilitate effectively. Recently, dual-active-center catalysts have emerged as a solution by enabling synergistic reactions. This review covers advances in these catalysts, their co-catalytic mechanisms, and applications in electro-Fenton, photocatalytic, peroxymonosulfate-, and pollutant-as-electron-donor based Fenton-like processes, along with active site design considerations and future challenges.
Schizophrenia-related Xpo7 haploinsufficiency leads to behavioral and nuclear transport pathologies
Authors: Toyoda Saori , Kikuchi Masataka , Abe Yoshifumi , Tashiro Kyosei , Handa Takehisa , Katayama Shingo , Motokawa Yukiko , Tanaka Kenji F , Takahashi Hidehiko , Shiwaku Hiroki 
Published: January 2025

Abstract
Recent genetic studies by the Schizophrenia Exome Sequencing Meta-Analysis (SCHEMA) consortium have identified that protein-truncating variants of exportin 7 (XPO7) can increase the risk of schizophrenia (odds ratio, 28.1). Here we show that mice with Xpo7 haploinsufficiency (Xpo7+/− mice) present with cognitive and social behavioral impairments. Through proteome analysis using immunoprecipitation and frontal cortex nuclear isolation of Xpo7+/− mice, we identify 45 molecules interacting with Xpo7, including CutC, Rbfox3, and Gria3. Through single-nucleus RNA sequencing of the frontal cortex and striatum of Xpo7+/− mice differentiating between the onset and progressive stages, we also identify 284 gene expression changes that correlate with these stages. These genes encompass high-odds risk genes of schizophrenia identified by SCHEMA, including Gria3, Grin2A, Herc1, and Trio. Furthermore, our approach reveals 15 gene expression changes in the frontal cortex that correlate with the progressive stages. Our findings indicate the importance of investigating whether the interactions among the high-risk genes identified by SCHEMA contribute to a common schizophrenia pathology and underscore the significance of stage-dependent analysis.
Ginger leaf polyphenols mitigate β-amyloid toxicity via JNK/FOXO pathway activation in Caenorhabditis elegans
Authors: Gao Tao , Yan Ningning , Pu Yaying , Zhang Zhonghao , Duan Zhihao , Tang Zizhong , Huang Daojian , Chen Yanger , Yuan Shu , Yan Xiaorong , Yuan Ming 
Published: January 2025

Ginger leaf polyphenols (GLP) alleviated β-amyloid toxicity by activating the JNK/FOXO signaling pathway in Caenorhabditis elegans.
Synthetic biology in Mexico: Brief history, current landscape, and perspectives towards a bio‐based economy
Authors: Barboza‐Pérez Uriel E. , Pérez‐Zavala Ma de L. , Barboza‐Corona José E. 
Published: January 2025

AbstractSynthetic biology (SynBio) makes biology easier by leveraging engineering principles and other disciplines to design and construct biological systems with novel or enhanced functions. SynBio has led to the development of more sustainable biotechnological innovations that are in harmony with the environment, aiding the shift from a traditional to a bio‐based economy. Mexico has made significant advancements in biotechnology in academia and industry, but progress in engineering biology has been different. Nevertheless, several initiatives, mainly supported by the participation of Mexican International Genetically Engineered Machine (iGEM) teams in the jamboree, have contributed to the interest of SynBio. This review provides a brief overview of the significant role of the iGEM competition and the current landscape of synthetic biology in Mexico, including educational and citizen science initiatives, as well as an overview of Synbio research and the industrial landscape. Additionally, a brief description of the current laws governing biotechnology in the country is provided. Finally, we highlight the challenges, opportunities and perspectives for the development of synthetic biology and the potential that Mexico has for a biologically based economy.
The Senior Managers and Certification Regime in UK practice and global context
Authors: Hickman Eleanore , Brener Alan 
Published: January 2025

AbstractPublic anger following the 2007/9 financial crisis was exacerbated by the failure to hold people accountable. A Parliamentary Commission recommended new legislation which resulted in the Senior Managers and Certification Regime (SMCR). A few other jurisdictions (e.g. Ireland and Australia) adopted similar requirements. In this article we document interviews with individuals who are or have been directly involved in implementing the regime or are currently personally impacted by it. These interviews were conducted to assess the regimes effectiveness 8 years after its introduction and consider how the regime compares to those adopted elsewhere. Our research indicates a perception that when the SMCR was initially implemented in 2016, regulated firms went into over-drive to make the new regime effective, but that regulatory focus has since moved on. Our participants all appear to agree that the quality of documentation and level of accountability has improved, but the impact on culture and professionalism was more conflicted. On top of this there are specific concerns about regulatory process delays, the provision of references and recruitment and retention. Conversely, the question of lack of enforcement, over which concerns have previously been raised, appears to matter little except in relation to its role as a signalling device.
The incidence of cardiac surgery in adults with treated kidney failure in Australia: a retrospective cohort study
Authors: Keuskamp Dominic , Davies Christopher E. , Baker Robert A. , Polkinghorne Kevan R. , Reid Christopher M. , Smith Julian A. , Tran Lavinia , Williams-Spence Jenni , Wolfe Rory , Mcdonald Stephen P. 
Published: January 2025

Objective Kidney failure increases people’s risk of cardiovascular disease, sometimes requiring cardiac surgery. The aim of this study was to estimate the risk of cardiac surgery for adults with treated kidney failure in comparison with the general population in Australia. Methods We performed a population-based retrospective cohort study by linking data between the Australia and New Zealand Dialysis and Transplant Registry and the Australian and New Zealand Society of Cardiac and Thoracic Surgeons Cardiac Surgery Database, for 2010–2019. Age–sex-standardised surgery risk relative to the general population was estimated for adults receiving long-term dialysis and kidney transplant recipients, and subpopulations defined by procedure type, comorbidity, clinical status and dialysis-related factors. Results Among 1541 adults receiving treatment for kidney failure at the time of cardiac surgery in 2010–2019, the prevalence of comorbidity and risk factors was usually highest in those receiving dialysis, followed by transplant recipients and the general population (n = 113,126). For all major cardiac surgical procedure types, the incidence of surgery for adults receiving dialysis and transplant recipients exceeded that for the general population (e.g. isolated coronary artery bypass grafting relative rates 15.3 [95% CI 13.7–17.0] and 2.0 [1.6–2.6] respectively). Relative incidence was especially high for the dialysis cohorts with insulin-treated diabetes and those with body mass index <25 kg/m2. Conclusions Adults with treated kidney failure had a higher risk of cardiac surgery than the general population in Australia in 2010–2019, especially when associated with diabetes. Data linkage between clinical quality registries enabled estimation of the extent of cardiac surgical burden.
Open indirect inguinal hernia repair: a feasibility study on simple purse-string suture (SPSS) application at deep ring
Authors: Japhleth Elvis B. , Machine Edwin M. 
Published: January 2025

Background The standard sac ligation technique in open indirect inguinal hernia repair is characterised by isolation, transfixation and excision of the hernial sac followed by posterior wall repair. It is not clear how applying purse string at deep ring instead of ligating the sac impacts the postoperative outcomes. The aim of this study was to investigate the feasibility of simple purse-string suture (SPSS) application at deep ring in open inguinal hernia repair. Methods Patients in this prospective study had the sac identified and opened to expose deep ring. Vicryl 1 suture was then placed around deep ring, taking only peritoneum and leaving the distal sac. The posterior wall repair was standard. A 12-week follow-up postoperatively assessed the length of the operating time, length of hospital stays, postoperative pain, postoperative scrotal swelling, and haematoma. Cosmetic, hydrocele formation and recurrence follow up was for 24 months total. Results 104 patients had SPSS application. Mean operating time was 32.2 min. The 24-h postoperative pain scores were 94, 6 and 1% for pain scale scores of 2, 4, and 6 respectively. The mean length of hospital stay was 2.1 days. Recurrence rate was 2%, which is acceptable. There was no postoperative haematoma. Postoperative hydrocele occurred in one case. Conclusion SPSS application at deep ring in open indirect inguinal hernia repair involves minimal tissue dissection and has as good, if not more favourable outcomes than the standard sac ligation. SPSS technique is simple, safe, practical and its application could be used as an alternative technique to standard sac ligation.
Opening up research on English-medium instruction
Authors: Hultgren Anna Kristina , Yuksel Dogan , Zuaro Beatrice , Nao Marion , Wingrove Peter 
Published: January 2025

Abstract
The introductory paper to this special issue makes a call for interdisciplinarity in English as a medium of instruction (EMI) on the grounds that EMI can only be properly studied and its challenges addressed by understanding its entanglement with a wider political, economic and social restructuring of higher education. The paper first offers a taxonomy of interdisciplinarity, drawing a distinction between interdisciplinarity within and beyond applied linguistics, the former of which has been most common within EMI to date. Following a synopsis of each of the five contributions, we evaluate the extent to which the issue has achieved its objectives. While the special issue advocates strongly for interdisciplinarity, it also acknowledges the challenges of engaging in genuine interdisciplinary scholarship and points to the structures that work to uphold disciplinary boundaries. We conclude by offering some ways forward for interdisciplinarity in EMI, arguing particularly for interdisciplinarity that extends beyond applied linguistics.
Is p-Type Doping in SeO2 Feasible?
Authors: Xiao 肖 Zewen 泽文 
Published: January 2025

Abstract

p-type transparent oxide semiconductors (TOSs) are significant in the semiconductor industry, driving advancements in optoelectronic technologies for transparent electronic devices with unique properties. The recent discovery of p-type behavior in SeO2 has stimulated interest and confusion in the scientific community. In this Letter, we employ density functional theory calculations to reveal the intrinsic intrinsic insulating characteristics of SeO2 and highlight the substantial challenges in carrier doping. Our electronic structure analyses indicate that the Se 5s
2 states are energetically positioned too low to effectively interact with the O 2p orbitals, resulting in a valence band maximum (VBM) primarily dominated by the O 2p orbitals. The deep and localized nature of the VBM of SeO2 limits its potential as a high-mobility p-type TOS. Defect calculations demonstrate that all intrinsic defects in SeO2 exhibit deep transition levels within the bandgap. Regardless of the synthesis conditions, the Fermi level consistently resides in the mid-gap region. Furthermore, deep intrinsic acceptors and donors exhibit negative formation energies in the n-type and p-type regions, respectively, facilitating spontaneous formation and impeding external doping efforts. Thus, the reported p-type conductivity in SeO2 samples is unlikely to be intrinsic and is more plausibly attributable to reduced elemental Se, a well-known p-type semiconductor.
Applying the method of cases of equilibrium: from the unprecedented ‘case of equilibrium of Ampère’s motor’ to a contemporary deduction of Ampère’s electrodynamic force
Authors: Chaib João Paulo M C 
Published: January 2025

Abstract
The method of cases of equilibrium is a lesser-known technique that effectively bridges theory and practice to derive fundamental natural laws. In this article, we will explain the method of equilibrium cases: we will introduce the historical motivation behind the development of this technique and outline the differences from the interpolation method. We will describe how to obtain an unprecedented equilibrium case — suitable for easy replication in the classroom — based on Ampère’s motor phenomenon, which, along with two already known cases, will allow us to develop a contemporary approach to deducing Ampère’s force between current elements. To our knowledge, this method is unknown in courses of experimental or mathematical methods of electrodynamics. The deduction section will require prior knowledge of calculus and unit vector notation.
Compact wide-stopband slow-wave half-mode substrate integrated waveguide filter with interdigital complementary split-ring resonator metasurface
Authors: Huang Yong Mao , Huang Yujie , Ding Shuai , Wang Guoan , Bozzi Maurizio 
Published: January 2025

Abstract
In this work, a compact slow-wave half-mode substrate integrated waveguide (HMSIW) bandpass filter is developed by loading the proposed interdigital complementary split-ring resonator (IDCSRR) metasurface for wireless communication and sensing applications. The IDCSRR metasurface is constituted by etching interdigital slots inside the conventional CSRR, which can effectively enhance the product of the equivalent capacitance and inductance of the structure, and eventually reduce the resonant frequency. Through the evanescent-mode transmission generated in the HMSIW by the negative permittivity effect of the IDCSRR metasurface, a miniaturized filter can be realized. Later, to further reduce the filter size, capacitance-enhanced ring-mushroom units are patterned onto the HMSIW to generate slow-wave effects. Then, to improve the filter’s out-of-band suppression, the source-load coupling scheme is utilized to generate extra transmission zeros. Meanwhile, to further widen the stopband, meander spurlines are etched on the input and output microstrip lines to suppress the higher-order harmonics with their bandgap function. To demonstrate the availability of the aforementioned concepts, a bandpass filter based on the HMSIW-IDCSRR unit cell is realized. Measurements show that the fabricated prototype exhibits a center frequency (f
0) of 0.97 GHz. Moreover, the out-of-band suppression can reach 30 dB, with the upper stopband up to 4.31 f
0. Hence, the proposed filter achieves a good stopband and miniaturization performance.