bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cytokine release syndrome complicated with severe rashes induced by nivolumab plus ipilimumab therapy in a patient with non‐small cell lung cancer: A case report
Authors: Tsutsui Toshiharu , Hata Koki , Kawaguchi Makoto , Kobayashi Hiroaki , Kakizaki Yumiko , Miyashita Yoshihiro 
Published: June 2023

AbstractCytokine release syndrome (CRS) is a severe and life‐threatening toxicity typically reported in chimeric antigen receptor T cell therapy and is rarely reported in immune checkpoint inhibitor (ICI) therapy. This study reports the case of a 75‐year‐old Japanese woman who received nivolumab plus ipilimumab therapy for the postoperative recurrence of non‐small cell lung cancer. She was admitted to our hospital with fever, hypotension, hepatic disorder, and thrombocytopenia. We observed slight skin rashes on her neck on admission, which spread rapidly across her body within a few days. We diagnosed CRS complicated by severe rashes. CRS symptoms were resolved with corticosteroid therapy, and did not recur thereafter. CRS is a rare, but important, immune‐related adverse event associated with ICI therapy.
Current endodontic practice and use of newer technologies in Australia and New Zealand
Authors: Cheung MC , Parashos P 
Published: June 2023

AbstractBackgroundThis study investigated endodontic clinical preferences, adoption of newer technologies and information sources among dentists and endodontists.MethodsDental and endodontic society members in Australia and New Zealand were surveyed online regarding their endodontic treatment preferences, armamentarium, information sources and continuing professional education (CPE) attendance.ResultsComplete responses were received from 71 endodontic specialists or postgraduates (Group E) and 139 general dentists (Group D). Most of Group E used dental operating microscopes (95.8%), endodontic cone‐beam computed tomography (CBCT; 98.6%) and calcium silicate‐based materials (CSBMs; 97.2%), significantly more (P < 0.001) than Group D (86.3% used loupes, <32% used CBCT for endodontics or CSBMs). Most respondents used dental dam always for endodontics (94.3%), electronic apex locators (EAL; 81.0%) and engine‐driven nickel‐titanium (NiTi) instruments (91.4%); Group E had more experience with engine‐driven NiTi (P < 0.001). Endodontic CPE attendance was highest at dental association programs (P < 0.001) while hands‐on NiTi training attendance was highest via commercial companies (P < 0.05). Online information sources were commonly used (38.8% of Group D, 59.2% of Group E).ConclusionDental dam, EAL and engine‐driven NiTi were almost universally used. The endodontic group reported high adoption of newer endodontic technologies. Endodontic CPE and information sources should be further surveyed as online engagement evolves. © 2023 Australian Dental Association.
Diabetic retinopathy in China: Epidemiology, screening and treatment trends—A review
Authors: Li Xiaorong , Tan Tien‐En , Wong Tien Y. , Sun Xiaodong 
Published: June 2023

AbstractDiabetic retinopathy (DR) is the leading cause of vision impairment in the global working‐age population. In China, with one‐third of the world's diabetes population estimated at 141 million, the blindness prevalence due to DR has increased significantly. The country's geographic variations in socioeconomic status have led to prominent disparities in DR prevalence, screening and management. Reported risk factors for DR in China include the classic ones, such as long diabetes duration, hyperglycaemia, hypertension and rural habitats. There is no national‐level DR screening programme in China, but significant pilot efforts are underway for screening innovations. Novel agents with longer durations, noninvasive delivery or multi‐target are undergoing clinical trials in China. Although optimised medical insurance policies have enhanced accessibility for expensive therapies like anti‐VEGF drugs, further efforts in DR prevention and management in China are required to establish nationwide cost‐effective screening programmes, including telemedicine and AI‐based solutions, and to improve insurance coverage for related out‐of‐pocket expenses.
Surgical peri‐implantitis treatment with and without guided bone regeneration. A randomized controlled trial
Authors: Heitz‐Mayfield Lisa J. A. , Heitz Fritz , Koong Bernard , Huang Tom , Chivers Paola 
Published: June 2023

AbstractObjectiveTo evaluate the efficacy of reconstructive peri‐implantitis treatment.Materials and MethodsForty participants, with peri‐implantitis and a contained intraosseous defect, were randomized to access flap (control) or access flap with xenograft and collagen membrane (test). All received systemic antimicrobials. Blinded examiners recorded probing depths (PD), bleeding and suppuration on probing (BOP & SOP), soft tissue levels, and marginal bone levels (MBL) at baseline and 12 months. Patient reported outcomes were recorded. The primary outcome was PD change.ResultsAll 40 participants (40 implants) completed the 12‐month study. The mean (standard deviation) PD reduction (deepest site) was 4.2 (1.8) mm in the control and 3.7 (1.9) mm in the test group. MBL gain (deepest site) was 1.7 (1.6) mm in the control and 2.4 (1.4) mm in the test group. Absence of BOP & SOP was observed at 60% of both control and test implants. Buccal recession was 0.9 (1.6) mm in the control and 0.4 (1.1) mm in the test group. A successful outcome (absence of PD ≥ 5 mm with BOP, absence of SOP and absence of progressive bone loss) was achieved for 90% of the control and 85% of test group implants. No statistically significant differences in clinical or radiographic parameters were found between treatment groups. 30% of participants experienced mild gastro‐intestinal disturbances. Reporting followed CONSORT guidelines.ConclusionSimilar clinical and radiographic improvements at 12 months were observed with high levels of patient satisfaction for both the access flap and xenograft covered by collagen membrane groups.Registered clinical trials.gov. ID:NCT03163602 (23/05/2017).
F‐words and early intervention ingredients for non‐ambulant children with cerebral palsy: A scoping review
Authors: De Campos Ana Carolina , Hidalgo‐Robles Álvaro , Longo Egmar , Shrader Claire , Paleg Ginny 
Published: June 2023

AbstractAimTo explore the ingredients of early interventions provided to young children with cerebral palsy (CP) who are classified in Gross Motor Function Classification System (GMFCS) levels IV and V, and to identify the ‘F‐words’ addressed by the interventions.MethodSearches were completed in four electronic databases. Inclusion criteria were the original experimental studies that fitted the following PCC components: population, young children (aged 0–5 years, at least 30% of the sample) with CP and significant motor impairment (GMFCS levels IV or V, at least 30% of the sample); concept, non‐surgical and non‐pharmacological early intervention services measuring outcomes from any of the International Classification of Functioning, Disability and Health domains; and context, studies published from 2001 to 2021, from all settings and not limited to any specific geographical location.ResultsEighty‐seven papers were included for review, with qualitative (n = 3), mixed‐methods (n = 4), quantitative descriptive (n = 22), quantitative non‐randomized (n = 39), and quantitative randomized (n = 19) designs. Fitness (n = 59), family (n = 46), and functioning (n = 33) ingredients were addressed by most experimental studies, whereas studies on fun (n = 6), friends (n = 5), and future (n = 14) were scarce. Several other factors (n = 55) related to the environment, for example, service provision, professional training, therapy dose, and environmental modifications, were also relevant.InterpretationMany studies positively supported formal parent training and use of assistive technology to promote several F‐words. A menu of intervention ingredients was provided, with suggestions for future research, to incorporate them into a real context within the family and clinical practice.What this paper adds

Family‐centred care (including coaching and caregiver‐delivered interventions) and formal parental training are effective strategies for children in GMFCS levels IV and V.
Assistive technology ingredients (power, mobility, supported, sitting, stepping, and standing) may promote several ‘F‐words’ (functioning, fitness, family, fun, friends, and future).
The lowest level of evidence was found for fun, friends, and future.
Other factors (service provision, professional training, therapy dose, environmental modifications) are relevant for young children in GMFCS levels IV and V.
Bayesian multilevel hidden Markov models identify stable state dynamics in longitudinal recordings from macaque primary motor cortex
Authors: Kirchherr Sebastien , Mildiner Moraga Sebastian , Coudé Gino , Bimbi Marco , Ferrari Pier F. , Aarts Emmeke , Bonaiuto James J. 
Published: June 2023

AbstractNeural populations, rather than single neurons, may be the fundamental unit of cortical computation. Analysing chronically recorded neural population activity is challenging not only because of the high dimensionality of activity but also because of changes in the signal that may or may not be due to neural plasticity. Hidden Markov models (HMMs) are a promising technique for analysing such data in terms of discrete latent states, but previous approaches have not considered the statistical properties of neural spiking data, have not been adaptable to longitudinal data, or have not modelled condition‐specific differences. We present a multilevel Bayesian HMM addresses these shortcomings by incorporating multivariate Poisson log‐normal emission probability distributions, multilevel parameter estimation and trial‐specific condition covariates. We applied this framework to multi‐unit neural spiking data recorded using chronically implanted multi‐electrode arrays from macaque primary motor cortex during a cued reaching, grasping and placing task. We show that, in line with previous work, the model identifies latent neural population states which are tightly linked to behavioural events, despite the model being trained without any information about event timing. The association between these states and corresponding behaviour is consistent across multiple days of recording. Notably, this consistency is not observed in the case of a single‐level HMM, which fails to generalise across distinct recording sessions. The utility and stability of this approach is demonstrated using a previously learned task, but this multilevel Bayesian HMM framework would be especially suited for future studies of long‐term plasticity in neural populations.
Multidimensional assessment of heartbeat‐evoked responses in disorders of consciousness
Authors: Candia‐Rivera Diego , Machado Calixto 
Published: June 2023

AbstractBecause consciousness does not necessarily translate into overt behaviour, detecting residual consciousness in noncommunicating patients remains a challenge. Bedside diagnostic methods based on EEG are promising and cost‐effective alternatives to detect residual consciousness. Recent evidence showed that the cortical activations triggered by each heartbeat, namely, heartbeat‐evoked responses (HERs), can detect through machine learning the presence of minimal consciousness and distinguish between overt and covert minimal consciousness. In this study, we explore different markers to characterize HERs to investigate whether different dimensions of the neural responses to heartbeats provide complementary information that is not typically found under standard event‐related potential analyses. We evaluated HERs and EEG average non‐locked to heartbeats in six types of participants: healthy state, locked‐in syndrome, minimally conscious state, vegetative state/unresponsive wakefulness syndrome, comatose and brain‐dead patients. We computed a series of markers from HERs that can generally separate the unconscious from the conscious. Our findings indicate that HER variance and HER frontal segregation tend to be higher in the presence of consciousness. These indices, when combined with heart rate variability, have the potential to enhance the differentiation between different levels of awareness. We propose that a multidimensional evaluation of brain–heart interactions could be included in a battery of tests to characterize disorders of consciousness. Our results may motivate further exploration of markers in brain–heart communication for the detection of consciousness at the bedside. The development of diagnostic methods based on brain–heart interactions may be translated into more feasible methods for clinical practice.
Marketing information system based on unsupervised visual data to manage transportation industry using signal processing
Authors: Aggarwal Kapil , Khoa Bui Thanh , Sagar K. V. Daya , Agrawal Ruchi , Dhingra Mallika , Dhingra Jagrit , R Lakshmana Kumar 
Published: June 2023

AbstractAdvance signal processing techniques are becoming one of the essential requirements for secure and efficient communication in the future innovative world. These requirements are due to the tremendous advancement of various latest cutting‐edge technologies that are very useful for the present generation. Marketing information system visualization is essential for the services of every advanced technology established in this way to reach people. Citing this, signal processing is a significant issue in most new technological innovations and challenges in various applications. A marketing information system, or MIS, based on these processes provides a valuable marketing method that helps marketers make better decisions. In this mode of operation, the existing methods are discarded, and the new methods, such as visual images, sound waves, and seismic waves, are implemented as digital signal processes, and their benefits are used as inputs for the processing of humankind. Based on this perspective, collaborative Management Information Systems (MIS) is proposed. This process‐based bridge enables MIS professionals to benefit from their investments in personnel, equipment, and business processes. In particular, transportation challenges such as total order intensity ratio, rising fuel prices, unexpected delays in transportation, shortage of skilled workers, deplorable warehouse conditions, insufficient and over‐stressed delivery staff, etc., and how road transport is giving its full attention to these fluctuations. Research paper explains very clearly and adequately explains the impact of such explained traffic problems, such as the volume of traffic and passengers, road network, lack of rehabilitation of half of the roads, and lack of national highways. Performance analysis for MIS measures with various factors is taken, and how the process varies in them and the answers to them are clarified through this research. This research citation shows how the marketing performance of an MIS measures the best practices in this research. Through this, online marketing performance based on MIS measures can be increased through MIS analysis reports for MIS measures. Finally, the Performance of the proposed MIS‐Transport with the MIS‐hospital Industry is taken as an example and explained.
Reciprocal associations between commitment, forgiveness, and different aspects of marital well‐being among Chinese newlywed couples
Authors: Li Qingyin , Guo Jinxuan , Chen Ziyuan , Ju Xiaoyan , Lan Jing , Fang Xiaoyi 
Published: June 2023

AbstractThis study examined the reciprocal prospective associations between commitment, forgiveness, and different aspects of marital well‐being (marital satisfaction and marital instability) among Chinese newlywed couples and the gender differences in these associations. The Vulnerability‐Stress‐Adaptation (VSA) model posits reciprocal associations between adaptive processes and relationship satisfaction. However, the directionality of the associations between adaptive processes and marital satisfaction may differ from the associations between adaptive processes and marital instability in Chinese societies due to the emphasis on relationship maintenance. Based on three annual waves of data from 268 Chinese newlywed couples (Mage = 29.59, SD = 3.25 for husbands; Mage = 28.08, SD = 2.51 for wives), a cross‐lagged approach was used to examine the reciprocal associations between commitment, forgiveness, and marital satisfaction/instability. We found: (a) reciprocal associations between commitment/forgiveness and marital satisfaction (wives only); (b) reciprocal associations between forgiveness and marital instability (husbands only); and (c) wives' commitment at Wave 2 mediated the association between wives' commitment at Wave 1 and wives' marital satisfaction at Wave 3. Extending the VSA model, findings suggest different reciprocal associations between commitment, forgiveness, and different aspects of marital well‐being among Chinese newlywed couples. Results highlight the important role of culture and gender in marital relationships and clinical practice.
Field‐scale analysis of miscanthus production indicates climate change may increase the opportunity for water quality improvement in a key Iowa watershed
Authors: Ferin Kelsie M. , Balson Tyler , Audia Ellen , Ward Adam S. , Liess Stefan , Twine Tracy E. , VanLoocke Andy 
Published: June 2023

AbstractThe Raccoon River Basin is the primary source for drinking water in Iowa's largest city and plays a major role in the Mississippi River Basin's high nutrient exports. Future climate change may have major impacts on the biological, physiological, and agronomic processes imposing a threat to ecosystem services. Efforts to reduce nitrogen (N) loads within this basin have included local litigation and the implementation of the Iowa Nutrient Reduction Strategy, which suggest incorporating bioenergy crops (i.e., miscanthus) within the current corn–soybean landscape to reach a 41% reduction in nitrate loads. This study focuses on simulating N export for historical and future land use scenarios by using an agroecosystem model (Agro‐IBIS) and a hydrology model (THMB) at the 500‐m resolution, similar to the scale of agricultural fields. Model simulations are driven by CMIP5 climate data for historical, mid‐century, and late‐century under the RCP 4.5 and 8.5 warming projections. Using recent crop profit analyses for the state of Iowa, profitability maps were generated and nitrogen leaching thresholds were used to determine where miscanthus should replace corn–soybean area to maximize reductions in N pollution. Our results show that miscanthus inclusion on low profit and high N leaching areas can result in a 4% reduction of N loss under current climate conditions and may reduce N loss by 21%–26% under future climate conditions, implying that water quality has the potential continue to improve under future climate conditions when strategically implemented conservation practices are included in future farm management plans.
Educational initiatives in headache medicine: A 20‐year scoping review
Authors: Dominguez Moises , Minen Mia , Robbins Matthew S. 
Published: June 2023

AbstractBackgroundHeadache disorders are among the most common and disabling medical conditions worldwide, have a great societal impact and are a common reason to seek medical care. Headache disorders are often misdiagnosed and undertreated, and the number of headache fellowship‐trained physicians cannot meet patient demand. Educational initiatives for non‐headache‐specialist clinicians may be an avenue to increase clinician competency and patient access to appropriate management.ObjectiveTo undertake a scoping review of the educational initiatives in headache medicine for medical students, trainees, general practitioners/primary care physicians, and neurologists.MethodsFollowing the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses guidelines for scoping reviews, an author (M.D.), with the help of a medical librarian, conducted a search of the Embase, Ovid Medline, and PsychInfo databases for articles related to medical educational initiatives on headache medicine in medical students, residents, and physicians over the last 20 years.ResultsA total of 17 articles met the inclusion criteria for this scoping review. Six articles were identified for medical students, seven for general practitioners/primary care physicians, one for emergency medicine residents, two for neurology residents, and one for neurologists. Certain educational initiatives were headache‐focused while others had headaches as one of the educational topics. Educational content was delivered and assessed via diverse and innovative means, such as flipped classroom, simulation, theatrical performance, repeated quizzing and study, and a formalized headache elective.ConclusionEducation initiatives in headache medicine are important to improve competency and patient access to appropriate management of various headache disorders. Future research should focus on using innovative and evidence‐based methods of content delivery, knowledge, and procedural assessment, and evaluating changes in practice behaviors.
The expression and function of theB7family inHelicobacter pyloriinfection and gastric carcinogenesis process
Authors: Zhang Yuan , Zhao Zhenkun , Fu Weiwei , Ding Shigang 
Published: June 2023

AbstractBackgroundThe B7 protein family is one of the most important immune checkpoint proteins. Gastric cancer (GC) is the fourth most common cause of cancer‐related mortality worldwide and shows a significant correlation with the B7 family in tumorigenesis and progression.Helicobacter pyloriinfection is the most important risk factor promoting the progression of gastric precancerous lesions and GC,which also affects the expression of B7 family members. We aimed to systematically summarize and review current studies on the expression and function of B7 family members duringH. pyloriinfection in precancerous gastric lesions and GC.Materials and MethodsPubMed was searched for the relationship between B7 family,H. pyloriand gastric carcinogenesis until April 5, 2023. Different permutation and combination of the search terms, including “H. pylori,” “Helicobacter pylori,” “B7,” “gastric cancer,” and “gastric precancerous lesions,” all the different names of specific B7 molecules, and the names of signaling pathways were used. Literature related to our research topic was selected and summarized.ResultsThe B7 family participates in gastric carcinogenesis through certain immune signaling pathways by binding to their receptors and exhibiting co‐inhibitory or co‐stimulatory effects. Targeting the B7 family members with mAbs may be a promising therapeutic strategy for treating gastric diseases.ConclusionsA thorough understanding of the role of B7 molecules duringH. pyloriinfection and GC progression is helpful for the treatment and prevention of GC and the prediction ofH. pyloriinfection outcomes, providing evidence forH. pylorieradication.