bluuebunny/crossref_metadata_2025_split huggingface dataset:
Executive Function Predicts Older Adults’ Lure Discrimination Difficulties on the Mnemonic Similarity Task
Authors: Jensen Adelaide , Karpov Galit , Collin Charles A , Davidson Patrick S R 
Published: June 2023

AbstractObjectivesOlder adults often have difficulty remembering the details of recently encountered objects. We previously found this with the Mnemonic Similarity Task (MST). Surprisingly, the older adults’ MST Lure Discrimination Index (LDI) was significantly correlated with visual acuity but not with memory or executive function. Here we ran a replication with new, larger samples of young (N = 45) and older adults (N = 70). We then combined the original and replication older adult samples (N = 108) to critically examine the relative contributions of visual acuity, memory, and executive function composite scores to LDI performance using dominance analysis. This provided, to our knowledge, the first direct statistical comparison of all 3 of these factors and their interactions on LDI.MethodsParticipants completed the MST and a battery assessing visual acuity, memory, and executive function. We examined age group differences on MST performance in the new (i.e., replication) young and older adult samples and performed multiple regression and dominance analysis on the combined older adult sample.ResultsConsistent with previous findings, the older adults showed significantly poorer LDI but preserved item recognition. LDI was significantly correlated with both memory and executive function but not with visual acuity. In the combined older adult sample, all 3 composites predicted LDI, but dominance analysis indicated that executive function was the most important predictor.DiscussionOlder adults’ MST LDI difficulty may be predicted by their executive function and visual acuity. These factors should be considered when interpreting older adults’ MST performance.
Functional Connectivity Alterations of Cognitive Flexibility in Aging: Different Patterns of Global and Local Switch Costs
Authors: Li Ting , Xia Haishuo , Li Huai , He Qinghua , Chen Antao 
Published: June 2023

Abstract

Objectives
Cognitive flexibility declines with aging and is usually indicated by task switch costs including global and local switch costs. Cognitive flexibility in aging is associated with alterations in functional connectivity. However, whether different task-modulated connectivity mechanisms underlying global and local switch costs remain unclear.

Methods
Here we use the support vector machine to identify age-related functional connectivity in global and local switch costs between older (n = 32) and young adults (n = 33). Participants completed a cued task-switching task during the functional magnetic resonance imaging scan.

Results
Results show an age-related decline behaviorally in global but not in local switch costs. Moreover, distinct patterns of age-related alterations of connectivity were observed for each cost. Specifically, only multivariate changes in connectivity patterns were observed for local switch cost, whereas specific age-related connections were revealed for global switch cost. In older adults, the task-modulated left dorsal premotor cortex–left precuneus connectivity decreased, and the left inferior frontal junction–left inferior parietal sulcus connectivity correlated with decreased global switch cost.

Discussion
This study provides novel evidence for different neural patterns in global and local switch costs by illuminating connectivity mechanisms underlying cognitive flexibility in aging.
The Value of Medicare Coverage on Depressive Symptoms Among Older Immigrants
Authors: Jun Hankyung , Mattke Soeren , Chen Alice , Aguila Emma 
Published: June 2023

Abstract

Background and Objectives
The immigrant population, the primary driver of U.S. population growth, is aging and many immigrants remain uninsured. Lack of health insurance limits access to care, aggravating the already high level of depression for older immigrants. However, there is scarce evidence on how health insurance, particularly Medicare, affects their mental health. Using the Health and Retirement Study, this study examines the effect of Medicare coverage on depressive symptoms of older immigrants in the United States.

Research Design and Methods
Exploiting the fact that many immigrants are not covered by Medicare after passing age 65, we use a difference-in-difference model with propensity score weighting to compare differences in depressive symptoms pre- and post-age-65. We further stratify the sample by socioeconomic status and by race/ethnicity.

Results
Medicare coverage was significantly associated with a reduction in the probability of reporting depressive symptoms for immigrants with low socioeconomic status, especially for those below median wealth levels. The beneficial effect of Medicare coverage was also statistically significant for non-White immigrants—Black, Hispanic, and Asian/Pacific Islander—even when holding socioeconomic status constant.

Discussion and Implications
Our findings imply that immigration policies that expand health care protection to older immigrants can lead to further health benefits and reduce existing disparities for the aging population. Policy reforms such as providing limited Medicare access to immigrants who paid sufficient taxes but are still awaiting permanent residency status could increase coverage for the uninsured and improve participation of immigrants in the payroll system.
The Moral and Gender Implications of Measures Used to Modulate the Mobility of People With Dementia Living in Residential Care Environments: A Scoping Review
Authors: Sturge Jodi , Janus Sarah , Zuidema Sytse , Frederiks Brenda , Schweda Mark , Landeweer Elleke 
Published: June 2023

Abstract

Background and Objectives
Policies and measures often restrict the mobility of people with dementia living in residential care environments to protect them from harm. However, such measures can violate human rights and affect the quality of life. This review aims to summarize the literature on what is known about measures used to modulate the life-space mobility of residents with dementia living in a residential care environment. Furthermore, moral and sex and gender considerations were explored.

Research Design and Methods
A scoping review framework was referenced to summarize the literature. A total of 5 databases were searched: PubMed, Embase, CINAHL, SCOPUS, and Web of Science. The studies for eligibility using the Rayyan screening tool.

Results
A total of 30 articles met the inclusion criteria. A narrative description of the findings of the articles is presented across 3 themes: (1) measures and strategies used to modulate the life-space mobility; (2) moral aspects; and (3) sex and gender considerations.

Discussion and Implications
Various measures are used to modulate the life-space mobility of people with dementia living in residential care facilities. Research exploring the sex and gender differences of people with dementia is lacking. With a focus on human rights and quality of life, measures used to restrict or support mobility must support the diverse needs, capacity, and dignity of people with dementia. Noting the capacity and diversity of people with dementia will require society and public space to adopt strategies that promote safety and mobility to support the quality of life of people with dementia.
Older Adults’ Perspectives of Independence Through Time: Results of a Longitudinal Interview Study
Authors: Taylor Emily , Goodwin Victoria A , Ball Susan , Clegg Andrew , Brown Lesley , Frost Julia 
Published: June 2023

Abstract

Background and Objectives
Understanding how older people experience independence has implications for person-centered care. Existing understanding of older people’s experience of independence, generated through methods that provide a “snapshot” view of a person’s independence at a given time point, provides little insight into the process of maintaining independence through time. The aim of this study was to explore older participants’ perceptions to understand the processes and resources that were most important for maintaining independence.

Research Design and Methods
Two semistructured interviews were conducted longitudinally to explore the perspectives of 12 community-dwelling, older people, aged 76–85 years. A social constructivist approach, using dramaturgical and descriptive codes, facilitated the interpretation of the data. Sixteen analytical questions guided the exploration of participants’ perceptions of independence through time.

Results
Older people suggested that objective representations underestimated, and omitted, important aspects of their independence through time. Some participants perceived “snapshot” judgments of their independence as insensitive to their individual values and context. Change over time required some participants to adapt their methods for maintaining independence. The stability of participants’ sense of independence was value dependent and informed by the purpose a participant ascribed to maintaining independence.

Discussion and Implications
This study augments the understanding of independence as a complex and multifaceted construct. The findings challenge the congruence of common interpretations of independence with older people’s views, showing areas of commonality, and discrepancy. Exploration of independence in terms of form and function provides an important understanding of how function takes precedence to form in determining the maintenance of independence through time.
No apology necessary? How narratives impact redress for colonialism in Namibia and India
Authors: Miller Manjari Chatterjee 
Published: June 2023

Abstract
Why do victim states not ask for redress from perpetrator states? Focusing on former extractive colonies, the vast majority of which, despite having suffered brutal colonial rule, have not asked for redress—apologies, reparations or restitution—from their former colonizers, this article argues that the content of historical narratives in the victim state matters for interstate redress. When meta and sub-narratives in victim states do not conform with each other, framing and consensus mobilization on interstate redress is stymied. To show this, I code interstate redress in the Correlates of War data set of colony/colonizer states, and then use primary sources—interviews and school textbooks—to examine two victim states: Namibia, a ‘less likely’ case which has sought interstate redress, and India, a ‘more likely’ case which has not. Academic and policy conversations on interstate redress have thus far largely focused on perpetrator states. This not only denies victim states, most of which are developing countries, agency but skews our understanding of the phenomenon of seeking justice across international borders.
Blue paradigms: understanding the intellectual revolution in global ocean politics
Authors: Bueger Christian , Mallin Felix 
Published: June 2023

Abstract
The oceans have received extraordinary international attention in global policy and research. New insecurities and uncertainties, ranging from intensifying interstate disputes to persistent piracy and overfishing as well as to pollution, deoxygenation and climate change imply that the oceans are increasingly seen as being in crisis. This revolution in thinking about and addressing the oceans is driven by new ideas of why the oceans need political attention and care. In this article we demonstrate how four key new ‘blue paradigms’—maritime security, blue economy, ocean health and blue justice—have evolved and turned the oceans into a new area of priority. Each of these paradigms drives global ocean politics in different directions, which implies risks of fragmentation and conflicts. We work out the key differences between paradigms, investigating their underlying problematization, priorities and communities of practices involved. This provides a new map for navigating the complexity of global ocean politics useful for policy-makers and scholars. Thinking through paradigms also establishes a new analytical framework that allows for identifying conflicting priorities, tensions between ocean communities of practice, and ideas of how these can be managed. We conclude with a call for creative thinking of how synergies between the blue paradigms can be achieved in strategy, planning and research.
Systemic immunometabolism and responses to vaccines: insights from T and B cell perspectives
Authors: Nettelfield Sam , Yu Di , Cañete Pablo F 
Published: June 2023

Abstract
Vaccination stands as the cornerstone in the battle against infectious diseases, and its efficacy hinges on several host-related factors like genetics, age, and metabolic status. Vulnerable populations, such as malnourished individuals, the obese, and the elderly, commonly exhibit diminished vaccine responses and efficacy. While the specific factors contributing to this impairment may vary, these individuals typically display a degree of metabolic dysregulation, thereby underscoring its potential significance as a fundamental determinant of suboptimal vaccine responses. The emerging field of immunometabolism aims to unravel the intricate interplay between immune regulation and metabolic pathways, and recent research has revealed diverse metabolic signatures linked to various vaccine responses and outcomes. In this review, we summarize the major metabolic pathways utilized by B and T cells during vaccine responses, their complex and varied metabolic requirements, and the impact of micronutrients and metabolic hormones on vaccine outcomes. Furthermore, we examine how systemic metabolism influences vaccine responses and the evidence suggesting that metabolic dysregulation in vulnerable populations can lead to impaired vaccine responses. Lastly, we reflect on the challenge of proving causality with respect to the contribution of metabolic dysregulation to poor vaccine outcomes, and highlight the need for a systems biology approach that combines multimodal profiling and mathematical modelling to reveal the underlying mechanisms of such complex interactions.
Unethical Issues in Twenty-First Century International Development and Global Health Policy
Authors: Hanson-DeFusco Jessi , Malik Sakil , Assamoi Rosine , Chiromba Antony , Davis Decontee , Hounnouvi Fidèle Marc , Irfan Furqan B , Faley Patrick , Matangwa Djo Dieudonne , Muzenda Tambu , Nakiryowa Hanifa , Obondoh Andiwo , Parveen S , Pinales Ana Julia , Zimunya Rugare 
Published: June 2023

AbstractBillions in development aid is provided annually by international donors in the Majority World, much of which funds health equity. Yet, common neocolonial practices persist in development that compromise what is done in the name of well-intentioned policymaking and programming. Based on a qualitative analysis of fifteen case studies presented at a 2022 conference, this research examines trends involving unethical partnerships, policies, and practices in contemporary global health. The analysis identifies major modern-day issues of harmful policy and programming in international aid. Core issues include inequitable partnerships between and representation of international stakeholders and national actors, abuse of staff and unequal treatment, and new forms of microaggressive practices by Minority World entities on low-/middle-income nations (LMICs), made vulnerable by severe poverty and instability. When present, these issues often exacerbate institutionalized discrimination, hostile work environments, ethnocentrism, and poor sustainability in development. These unbalanced systems perpetuate a negative development culture and can place those willing to speak out at risk. At a time when the world faces increased threats including global warming and new health crises, development and global health policy and practice must evolve through inclusive dialogue and collaborative effort.
Integrating human-centered design in public health data dashboards: lessons from the development of a data dashboard of sexually transmitted infections in New York State
Authors: Ansari Bahareh , Martin Erika G 
Published: June 2023

Abstract

Objective
The increased availability of public data and accessible visualization technologies enhanced the popularity of public health data dashboards and broadened their audience from professionals to the general public. However, many dashboards have not achieved their full potential due to design complexities that are not optimized to users’ needs.

Material and Methods
We used a 4-step human-centered design approach to develop a data dashboard of sexually transmitted infections for the New York State Department of Health: (1) stakeholder requirements gathering, (2) an expert review of existing data dashboards, (3) a user evaluation of existing data dashboards, and (4) an usability evaluation of the prototype dashboard with an embedded experiment about visualizing missing race and ethnicity data.

Results
Step 1 uncovered data limitations and software requirements that informed the platform choice and measures included. Step 2 yielded a checklist of general principles for dashboard design. Step 3 revealed user preferences that influenced the chart types and interactive features. Step 4 uncovered usability problems resulting in features such as prompts, data notes, and displaying imputed values for missing race and ethnicity data.

Discussion
Our final design was accepted by program stakeholders. Our modifications to traditional human-centered design methodologies to minimize stakeholders’ time burden and collect data virtually enabled project success despite barriers to meeting participants in-person and limited public health agency staff capacity during the COVID-19 pandemic.

Conclusion
Our human-centered design approach and the final data dashboard architecture could serve as a template for designing public health data dashboards elsewhere.
Purification methods to reduce interference by dextran sodium sulfate with quantification of gene expression in intestinal tissue samples from a piglet model of colitis
Authors: Sommer Kaitlyn M , Lee Youngsoo , Donovan Sharon M , Dilger Ryan N 
Published: June 2023

Abstract
Dextran sodium sulfate (DSS) is commonly used to induce intestinal (i.e., colonic) inflammation in a variety of animal models. However, DSS is known to cause interference when using quantitative-real time polymerase chain reaction (qRT-PCR) methods, thereby invalidating accurate and precise measurement of tissue gene expression. Therefore, the goal of this study was to determine whether different mRNA purification methods would reduce DSS-interference. Colonic tissue samples were collected at postnatal days (PND) 27 or 28 from pigs that had not been administered DSS (Control), and two independent groups of pigs that received 1.25 g of DSS/kg of BW/d (DSS-1 and DSS-2) from PND 14 to 18. Tissue samples collected were subsequently stratified into three purification methods (i.e., 9 total treatment × method combinations), including: 1) no purification, 2) purification with lithium chloride (LiCl), or 3) purification using spin column filtration. All data were analyzed using a one-way ANOVA in the Mixed procedure of SAS. The average RNA concentrations across all treatments were between 1,300 and 1,800 μg/μL for all three in vivo groups. Although there were statistical differences among purification methods, the 260/280 and 260/230 ratios fell between acceptable limits of 2.0 to 2.1 and 2.0 to 2.2, respectively, for all treatment groups. This confirms the RNA quality was adequate and not influenced by purification method in addition to suggesting the absence of phenol, salts, and carbohydrate contamination. For pigs in the Control group that did not receive DSS, qRT-PCR Ct values of four cytokines were achieved, though these values were not altered by purification method. For pigs that had undergone DSS dosing, those tissues subjected to either no purification or purification using LiCl did not generate applicable Ct values. However, when tissues derive from DSS-treated pigs underwent spin column purification, half of the samples from DSS-1 and DSS-2 groups generated appropriate Ct estimates. Therefore, spin column purification appeared to be more effective than LiCl purification, but no method was 100% effective, so caution should be exercised when interpreting gene expression results from studies where animals are exposed to DSS-induced colitis.
Jujuboside A ameliorates cognitive deficiency in delirium through promoting hippocampal E4BP4 in mice
Authors: Du Jianhao , Zhang Fugui , Chen Min , Xiao Yifei , Zhang Li , Dong Linlin , Dong Dong , Wu Baojian 
Published: June 2023

Abstract

Objective
Delirium (acute brain syndrome) is a common and serious neuropsychiatric disorder characterized by an acute decline in cognitive function. However, there is no effective treatment clinically. Here we investigated the potential effect of jujuboside A (JuA, a natural triterpenoid saponin) on cognitive impairment in delirium.

Methods
Delirium models of mice were established by injecting lipopolysaccharide (LPS) plus midazolam and implementing a jet lag protocol. Novel object recognition test and Y maze test were used to evaluate the effects of JuA on delirium-associated cognitive impairment. The mRNA and protein levels of relevant clock factors and inflammatory factors were measured by qPCR and Western blotting. Hippocampal Iba1+ intensity was determined by immunofluorescence staining.

Key findings
JuA ameliorated delirium (particularly delirium-associated cognitive impairment) in mice, which was proved by the behavioural tests, including a preference for new objects, an increase of spontaneous alternation and improvement of locomotor activity. Furthermore, JuA inhibited the expression of ERK1/2, p-p65, TNFα and IL-1β in hippocampus, and repressed microglial activation in delirious mice. This was attributed to the increased expression of E4BP4 (a negative regulator of ERK1/2 cascade and microglial activation). Moreover, loss of E4bp4 in mice abrogated the effects of JuA on delirium as well as on ERK1/2 cascade and microglial activation in the hippocampus of delirious mice. Additionally, JuA treatment increased the expression of E4BP4 and decreased the expression of p-p65, TNFα and IL-1β in LPS-stimulated BV2 cells, supporting a protective effect of JuA on delirium.

Conclusions
JuA protects against delirium-associated cognitive impairment through promoting hippocampal E4BP4 in mice. Our findings are of great significance to the drug development of JuA against delirium and related disorders.
The promising application of hydrogel microneedles in medical application
Authors: Wu Yanping , Tang Ziyan , Ma Shan , Du Lina 
Published: June 2023

Abstract

Objectives
Hydrogel microneedles are emerging, and promising microneedles mainly composed of swelling polymers. This review is intended to summarize the preparation materials, formation mechanisms, applications and existing problems of hydrogel microneedles.

Methods
We collected the literature on the materials, preparation and application of hydrogel microneedles in recent years, and summarized their mechanism and application in drugs delivery.

Key findings
Hydrogel microneedles have higher safety and capabilities of controlled drug release, and have been mainly used in tumour and diabetes treatment, as well as clinical monitoring. In recent years, hydrogel microneedles have shown great potential in drug delivery, and have played the role of whitening, anti-inflammatory and promoting healing.

Conclusions
As an emerging drug delivery idea, hydrogel microneedles for drug delivery has gradually become a research hotspot. This review will provide a systematic vision for the favourable development of hydrogel microneedles and their promising application in medicine, especially drug delivery.