bluuebunny/crossref_metadata_2025_split huggingface dataset:
SrCuSi4O10/GelMA Composite Hydrogel‐Mediated Vital Pulp Therapy: Integrating Antibacterial Property and Enhanced Pulp Regeneration Activity
Authors: Qiu Yu , Tian Jun , Kong Siyi , Feng Yanping , Lu Yangyu , Su Lefeng , Cai Yanling , Li Mengjie , Chang Jiang , Yang Chen , Wei Xi 
Published: June 2023

AbstractVital pulp therapy (VPT) is considered a conservative treatment for preserving pulp viability in caries‐induced dental pulp infections. However, bacterial contamination negatively affects dentine‐pulp complex repair. The common capping materials show limited antimicrobial effects against some microorganisms. To improve the VPT efficacy, capping materials with increased antibacterial properties and enhanced odontogenic and angiogenic activities are needed. Herein, a SrCuSi4O10/gelatin methacrylate(SC/Gel) composite hydrogel has been proposed for infected dental pulp treatment. SrCuSi4O10 (SC) is a microscale bioceramic composed of assembled multilayered nanosheets that possesses good near‐infrared photothermal conversion ability and multiple bioactivities due to sustained Sr2+, Cu2+, and SiO32− ion release. It is shown that the SC/Gel composite hydrogel efficiently eliminates Streptococcus mutans and Lactobacillus casei and inhibits biofilm formation under photothermal heating, while the ion extract from SC promotes odontogenesis of rat dental pulp stem cells and angiogenesis of human umbilical vein endothelial cells. The as‐designed therapeutic effect of SC/Gel composite hydrogel‐mediated VPT has been proven in a rat dental pulp infection model and yielded improved dentine‐pulp complex repair compared with the commercially used iRoot® BP Plus. This study suggests that the SC/Gel composite hydrogel is a potential pulp‐capping material with improved effects on dentine−pulp complex repair in infected pulp.
A Non‐G‐Quadruplex DNA Aptamer Targeting NCL for Diagnosis and Therapy in Bladder Cancer
Authors: Liu Yunyi , Hu Bei , Pei Xiaming , Li Juan , Qi Dan , Xu Yuxi , Ou Hailong , Wu Yatao , Xue Lei , Huang Jason H. , Wu Erxi , Hu Xiaoxiao 
Published: June 2023

AbstractBladder cancer (BC) is a highly aggressive malignant tumor affecting the urinary system, characterized by metastasis and a poor prognosis that often leads to limited therapeutic success. This study aims to develop a novel DNA aptamer for the diagnosis and treatment of BC using a tissue‐based systematic evolution of ligands by an exponential enrichment (SELEX) process. By using SELEX, this work successfully generates a new aptamer named TB‐5, which demonstrates a remarkable and specific affinity for nucleolin (NCL) in BC tissues and displays marked biocompatibility both in vitro and in vivo. Additionally, this work shows that NCL is a reliable tissue‐specific biomarker in BC. Moreover, according to circular dichroism spectroscopy, TB‐5 forms a non‐G‐quadruplex structure, distinguishing it from the current NCL–targeting aptamer AS1411, and exhibits a distinct binding region on NCL compared to AS1411. Notably, this study further reveals that TB‐5 activates NCL function by promoting autophagy and suppressing the migration and invasion of BC cells, which occurs by disrupting mRNA transcription processes. These findings highlight the critical role of NCL in the pathological examination of BC and warrant more comprehensive investigations on anti‐NCL aptamers in BC imaging and treatment.
Short‐Wavelength Infrared Organic Light‐Emitting Diodes from A–D–A′–D–A Type Small Molecules with Emission beyond 1100 nm
Authors: Liu Wansheng , Deng Suinan , Zhang Lianjie , Ju Cheng‐Wei , Xie Yuan , Deng Wanyuan , Chen Junwu , Wu Hongbin , Cao Yong 
Published: June 2023

AbstractShort‐wavelength infrared (SWIR) organic light‐emitting diodes (OLEDs) have attracted great interest due to their potential applications in biological imaging, infrared lighting, optical communication, environmental monitoring, and surveillance. Due to an intrinsic limitation posed by the energy‐gap law, achieving high‐brightness in SWIR OLEDs remains a challenge. Herein, the study reports the use of novel A–D–A′–D–A type small molecules NTQ and BTQ for high‐performance SWIR OLEDs. Benefiting from multiple D–A effect in conjugated skeleton, the small molecules NTQ and BTQ exhibit narrow optical gaps of 1.23 and 1.13 eV, respectively. SWIR electroluminescence (EL) emission from OLEDs based on NTQ and BTQ is achieved, with emission peaks at 1140 and 1175 nm, respectively. Not only owing to a negligible efficiency roll‐off across the full range of applied current density but also the ability to afford a high operation current density of 5200 mA cm−2, the resultant SWIR OLEDs based on NTQ exhibit a maximal radiant exitance of =1.12 mW cm−2. Furthermore, the NTQ‐based OLEDs also possess sub‐gap turn‐on voltage of 0.85 V, which is close to the physical limits derived from the generalized Kirchhoff and Planck equation. This work demonstrates that A–D–A′–D–A type small molecules offer significant promise for NIR/SWIR emitting material innovations.
Carboline Regioisomers Based on Unified Synthetic Approaches
Authors: Arshad Ahmad Saifuddin Mohamad , Mordi Mohd Nizam 
Published: May 2023

AbstractCarbolines are a prominent class of tricyclic alkaloids omnipresent in natural products and bioactive compounds. Four different carboline regioisomers are known (α‐, β‐, γ‐, and δ‐carbolines), which can be classified according to the nitrogen atom position inside the pyridine ring. As an emerging structural motif in drug discovery, a multitude of synthetic methods have been established for the construction of carboline frameworks, which in general requires customized approaches for the assembly of each regioisomer. Distinguishingly, their frameworks are also accessible from unified approaches, which are capable of generating multiple regioisomers, thus suitable for introducing diversity in isomeric carbolines. In this review, the construction of isomeric carbolines based on unified synthetic approaches is summarized.
A Generic “Engraving in Aprotic Medium” Strategy toward Stabilized Zn Anodes
Authors: Zou Yuhan , Su Yiwen , Qiao Changpeng , Li Weiping , Xue Zaikun , Yang Xianzhong , Lu Miaoyu , Guo Wenyi , Sun Jingyu 
Published: June 2023

AbstractZn foil pretreatment is a direct route to alleviating Zn anode instability and maintaining high energy performance in Zn metal batteries. Unfortunately, prevailing methods for achieving an ideal Zn surface texture do not enable durable operation under a large depth of discharge, thus impairing the Zn utilization ratio. Zn etching is a more feasible way to control the surface texture, but this approach remains relatively unexplored. In this study, a general strategy is reported for Zn foil engraving in aprotic media to realize efficient anode pretreatment in terms of stability. These tests are performed using high‐valence metal ions (especially Mo5+) in an aprotic environment as the key etchant to render a homogenously‐distributed, 3D porous architecture on the Zn foil surface. Comprehensive experimental results and theoretical simulations revealed enhanced Zn nucleation and growth. This specially designed electrode exhibited a long lifespan with a large depth of discharge of 88% in symmetric cells. When assembled with a ZnxV2O5 cathode, the constructed cell demonstrated nearly full capacity retention even under stringent conditions (e.g., an N/P capacity ratio of 5.5). This study demonstrates the potential of a Zn etching pretreatment to address the prototypical instability issues of Zn anodes.
Time from Onset to Remote Ischemic Conditioning and Clinical Outcome After Acute Moderate Ischemic Stroke
Authors: Cui Yu , Chen Yi‐Ning , Nguyen Thanh N. , Chen Hui‐Sheng 
Published: May 2023

ObjectiveWe conducted a post hoc exploratory analysis of Remote Ischemic Conditioning for Acute Moderate Ischemic Stroke (RICAMIS) to determine whether early remote ischemic conditioning (RIC) initiation after stroke onset was associated with clinical outcome in patients with acute moderate ischemic stroke.MethodsIn RICAMIS, patients receiving RIC treatment in the intention‐to‐treat analysis were divided into 2 groups based on onset‐to‐treatment time (OTT): early RIC group (OTT ≤ 24 hours) and late RIC group (OTT 24–48 hours). Patients receiving usual care without RIC treatment from intention‐to‐treat analysis were assigned as the control group. The primary outcome was excellent functional outcome at 90 days.ResultsAmong 1,776 patients from intention‐to‐treat analysis, 387 were in the early RIC group, 476 in the late RIC group, and 913 in the control group. In the post hoc exploratory analysis, a higher proportion of excellent functional outcome was found in the early RIC versus control group (adjusted absolute difference = 8.1%, 95% confidence interval [CI] = 2.5%–13.8%, p = 0.005), but no difference in outcomes was detected in the late RIC versus control group (adjusted absolute difference = 3.3%, 95% CI = −2.1% to 8.6%, p = 0.23), or in the early RIC versus late RIC group (adjusted absolute difference = 5.0%, 95% CI = −1.3% to 11.2%, p = 0.12). Similar results were found in the per‐protocol analysis.InterpretationAmong patients with acute moderate ischemic stroke who are not candidates for intravenous thrombolysis or endovascular therapy, early RIC initiation within 24 hours of onset may be associated with higher likelihood of excellent clinical outcome. ANN NEUROL 2023;94:561–571
Control of Quantum‐Memory Induced by Generated Thermal XYZ‐Heisenberg Entanglement: y‐Component DM Interaction
Authors: Aldosari Fahad M. , Alsahli Abdallah M. , Mohamed Abdel‐Baset A. , Rahman Atta 
Published: May 2023

AbstractThis study explores the thermal quantum‐memory‐assisted entropic uncertainty relation (QM‐EUR) and entanglement in a general two‐qubit XYZ‐Heisenberg spin chain model in the presence of the Dzyaloshinskii–Moriya (DM) interaction. The characterization of y‐component DM and spin–spin interactions are particularly focused. It is found that the DM and spin–spin interaction strengths highly regulate the flow behavior and the initial final levels of QM‐EUR and entanglement. In comparison, the spin–spin interaction strength in the z‐direction remains useful in both ferromagnetic and anti‐ferromagnetic regimes for entropic uncertainty suppression and entanglement generation. Additionally, the negative and the positive directed DM values can usefully turn classical states into resourceful quantum states. The dynamics of thermal QM‐EUR and entanglement‐of‐formation have symmetric behaviors only with respect to y‐component DM and z‐component spin–spin interaction. Finally, different critical points of temperature, component DM as well as spin–spin interaction are encountered, which should be opted to preserve quantum correlations and degrade uncertainty.
Totalsynthese von Thiamyxin A–C und Thiamyxin E, potente RNA‐Virus inhibierende (Cyclo)depsipeptide
Authors: Bauer Kevin , Kazmaier Uli 
Published: May 2023

AbstractWir präsentieren die erste Totalsynthese der Thiamyxine A–C und des jetzt vollständig charakterisierten Thiamyxins E, einer interessanten Klasse thiazol‐ und thiazolinreicher Depsipeptide mit vielfältiger antiviraler Aktivität. Die Synthese zeichnet sich aus durch einen parallelen Ringschluss zu zwei Methylthiazolin‐Einheiten unter geringer Epimerisierung des sehr labilen benachbarten stereogenen Zentrums. Des Weiteren wird die dreistufige Synthese einer ungewöhnlichen Hydroxysäure sowie die oxidationsfreie Eliminierung eines Phenylselenids zum Dehydroalanin gezeigt. Die Ausnutzung des säurelabilen Stereozentrums am Isoleucin‐Rest und die erneute Öffnung der Makrolactone ermöglichen den Zugang zu den vier Thiamyxinen in guten Ausbeuten und Diastereomerenverhältnissen aus einem einzigen Vorläufer. Durch die modular gestaltete Totalsynthese sind weitere Bioaktivitätstests und die Erforschung eines Pharmakophors über die Synthese weiterer Derivate möglich.
Directional and Ultrafast Charge Transfer in Oxygen‐Vacancy‐Rich ZnO@Single‐Atom Cobalt Core‐Shell Junction for Photo‐Fenton‐Like Reaction
Authors: Wu Xi‐Lin , Liu Shiang , Li Yu , Yan Minjia , Lin Hongjun , Chen Jianrong , Liu Shoujie , Wang Shaobin , Duan Xiaoguang 
Published: May 2023

AbstractIn photosynthesis, solar energy is harvested by photosensitizers, and then, the excited electrons transfer via a Z‐Scheme mode to enzymatic catalytic centers to trigger redox reactions. Herein, we constructed a core–shell Z‐scheme heterojunction of semiconductor@single‐atom catalysts (SACs). The oxygen‐vacancy‐rich ZnO core and single‐atom Co−N4 sites supported on nitrogen‐rich carbon shell (SA‐Co‐CN) act as the photosensitizer and the enzyme‐mimicking active centers, respectively. Driven by built‐in electric field across the heterojunction, photoexcited electrons could rapidly (2 ps) transfer from the n‐type ZnO core to the p‐type SA‐Co‐CN shell, finally boosting the catalytic performance of the surface‐exposed single‐atom Co−N4 sites for peroxymonosulfate (PMS) activation under light irradiation. The synergies between photocatalysis and heterogeneous Fenton‐like reaction lead to phenomenally enhanced production of various reactive oxygen species for rapid degradation of various microcontaminants in water. Experimental and theoretical results validate that the interfacial coupling of SA‐Co‐CN with ZnO greatly facilitates PMS adsorption and activation by reducing the adsorption energy and enhancing the cascade electron transfer processes for the photo‐Fenton‐like reaction.
Achieving Digital Catalysis: Strategies for Data Acquisition, Storage and Use
Authors: Marshall Clara Patricia , Schumann Julia , Trunschke Annette 
Published: May 2023

AbstractHeterogeneous catalysis is an important area of research that generates data as intricate as the phenomenon itself. Complexity is inherently coupled to the function of the catalyst and advance in knowledge can only be achieved if this complexity is adequately captured and accounted for. This requires integration of experiment and theory, high data quality and quality control, close interdisciplinary collaboration, and sharing of data and metadata, which is facilitated by the application of joint data management strategies. This Viewpoint Article first discusses the potential of a digital transition in catalysis research. Then, a summary of the current status in terms of data infrastructure in heterogeneous catalysis is presented, defining the various types of (meta‐) data, from catalyst synthesis to functional analysis. Finally, an already implemented working concept for local data acquisition and storage is introduced and the benefits and further development directions for catalysis data use and sharing are discussed.
Experimental study on the plugging and profile control of preformed particle gels in high temperature and salinity reservoir
Authors: Fan Huancai , Pu Wanfen , Du Daijun , Xu Mengsheng , Chen Lan , Xu Liang , Jin Fayang 
Published: May 2023

AbstractA novel modified polysaccharide composite preformed particle gel (MCPG) was synthesized as a profile control agent to improve the situation of high water cut and low oil recovery. Then, the structure of MCPG was characterized by Fourier transform infrared spectroscopy (FTIR), X‐ray diffraction (XRD), and environmental scanning electron microscope (ESEM). Subsequently, the impact of MCPG on enhanced oil recovery was investigated through nuclear magnetic resonance (NMR) and core displacement experiments. The results of FTIR, XRD, and ESEM indicate that monomers have been successfully intercalated into the layered structure of nanoscale sodium bentonite. In the condition of 130°C and salinity of 240,000 mg/L, the value of the swelling ratio and the toughness factor can reach about 30 and 0.87, respectively. The results of nonlinear fitting indicate that the relationship between the resistance coefficient and residual resistance coefficient with the matching coefficient (β) followed a power function, while the blocking water efficiency with β followed an exponential function. When the permeability ratio was as high as 30.58, MCPG still exhibited excellent profile improvement performance. NMR experiments proved that MCPG increased the displacement resistance in large pores and effectively enhanced the displacement efficiency in medium pores and small pores. The oil displacement efficiency in MCPG flooding and subsequent water flooding stages increased by 18.65% and 8.42%, respectively.
Tracing the spatial organization and activity zones of an Early Mediaeval homestead at the Pohansko stronghold (Czechia) by combining geophysics and geochemical mapping
Authors: Prišťáková Michaela , Adameková Katarína , Petřík Jan , Dresler Petr , Prokeš Lubomír 
Published: May 2023

AbstractGeoarchaeological prospection techniques were applied to identify activity zones and the inner structure of a homestead at the Early Mediaeval site Pohansko near Břeclav (Czechia). By a combination of geophysical methods, the spatial distribution of microartefacts, geochemical analysis and multivariate statistical analysis, we outlined various manifestations of anthropogenic activity. We examined obtained data by Spearman's correlation coefficient, spatial autocorrelation (Global Moran's I) and robust Principal component analysis to identify the spatial pattern of the area. Recognized joint presence of heavy metals (Pb, Zn and Cu) and elements related mostly to organic matter, waste and ashes (S, P and Ca) as well as a small number of slag fragments probably indicate presence of metalworking zones or mixed zones with domestic and industrial debris at the homestead. Further anthropogenic activities could be connected to manuring, animal management or some kind of production activities based on the presence of Mn, P and Cu. Bone and charcoal concentrations supplement the information of geochemical analysis and may indicate the manner of waste management in the peripheral parts of the homestead. In the middle of the homestead, the location of archaeological features indicates an open space in which no specific activity was detected. By means of magnetic susceptibility and judging from the presence of daub, we defined the potential presence of non‐sunken features, which were not recognized by magnetometry. The outcome of the study is yet to be verified by excavation.
Dopamine transporter binding in the brain is linked to irritable bowel syndrome in Parkinson's disease
Authors: Murtomäki Kirsi , Joutsa Juho , Mertsalmi Tuomas , Jaakkola Elina , Mäkinen Elina , Levo Reeta , Eklund Mikael , Nuuttila Simo , Pekkonen Eero , Noponen Tommi , Ihalainen Toni , Kaasinen Valtteri , Scheperjans Filip 
Published: May 2023

AbstractBackgroundGastrointestinal symptoms are common in Parkinson's disease (PD), but their neurophysiological correlates are not well understood. We recently reported that functional gastrointestinal symptoms were not associated with asymmetry per se but might be associated with lower left striatal dopamine transporter (DAT) binding. The purpose of this study was to further investigate if specific gastrointestinal symptoms associate with monoamine transporter changes in specific striatal or extrastriatal areas.MethodsNinety PD patients, who underwent DAT ¹23I‐FP‐CIT SPECT imaging, were assessed using the MDS‐Unified Parkinson's Disease Rating Scale part III, Rome III, and Wexner constipation score. DAT binding was calculated from striatal subregions using region‐to‐occipital cortex ratio. Voxel‐wise analysis was used to assess the relationship between gastrointestinal symptoms and striatal DAT and extrastriatal serotonin transporter (SERT) binding.ResultsIrritable bowel syndrome (IBS) criteria were fulfilled in 17 patients and were linked to higher ¹23I‐FP‐CIT binding in the right posterior putamen and adjacent areas as compared to patients without IBS. No other significant associations between gastrointestinal symptoms and DAT or SERT binding were found.ConclusionsThese findings suggest that PD patients with IBS may have higher DAT binding in the right hemisphere. This finding implicates alterations of brain neurotransmitter physiology in the gastrointestinal symptoms of PD patients.
Added value of molecular karyotype in childhood acute lymphoblastic leukemia
Authors: Camuset Margaux , Le Calvez Baptiste , Theisen Olivier , Godon Catherine , Grain Audrey , Thomas Caroline , Couec Marie‐Laure , Béné Marie C. , Rialland Fanny , Eveillard Marion 
Published: June 2023

AbstractBackgroundThanks to an improved therapeutic regimen in childhood B‐cell precursor acute lymphoblastic leukemia (BCP‐ALL), 5 year‐overall survival now exceeds 90%. Unfortunately, the 25% of children who relapse have an initial poor prognosis, potentially driven by pre‐existing or emerging molecular anomalies. The latter are initially and essentially identified by cytogenetics. However, some subtle alterations are not visible through karyotyping.MethodsSingle nucleotide polymorphisms (SNP) array is an alternative way of chromosomal analysis allowing for a more in‐depth evaluation of chromosomal modifications such as the assessment of copy number alterations (CNA) and loss of heterozygosity (LOH). This method was applied here in retrospective diagnosis/relapse paired samples from seven children with BCP‐ALL and in a prospective cohort of 38 newly diagnosed childhood cases.ResultsIn the matched study, compared to the initial karyotype, SNP array analysis reclassified two patients as poor prognosis cases. Modulation during relapse was seen for 4 CNA and 0.9 LOH. In the prospective study, SNP reclassified the 10 patients with intermediate karyotype as 7 good prognosis and 3 poor prognosis. Ultimately, in all the children tested, SNP array allowed to identify additional anomalies compared to conventional karyotype, refine its prognostic value and identify some druggable anomalies that could be used for precision medicine. Overall, the anomalies detected could be segregated in four groups respectively involved in B‐cell development, cell proliferation, transcription and molecular pathways.ConclusionSNP therefore appears to be a method of choice in the integrated diagnosis of BCP ALL, especially for patients initially classified as intermediate prognosis. This complementary method of both cytogenetics and high throughput sequencing allows to obtain further classified information and can be useful in case of failure of these techniques.
Tyrosine kinase inhibitors in HER2‐positive breast cancer brain metastases: A systematic review and meta‐analysis
Authors: Yu Yushuai , Huang Kaiyan , Lin Yuxiang , Zhang Jie , Song Chuangui 
Published: May 2023

AbstractBackgroundSmall tyrosine kinase inhibitors (TKIs) show activity against breast cancer brain metastases (BCBM) of the human epidermal growth factor receptor 2 (HER2)‐positive subtype. This meta‐analysis aimed to objectively explore the efficacy and safety of TKIs.MethodsElectronic databases were searched for relevant clinical trials. We conducted a pairwise meta‐analysis, pooled analysis, and estimated summary survival curves to compare survival outcomes following TKIs therapy for BCBM patients using Stata version 16.0 or R x64 4.0.5.ResultsThirteen clinical trials involving 987 HER2‐positive BCBM patients were analyzed. A trend of longer progression‐free survival (PFS) was observed in the TKI‐containing arm compared to the non‐TKI‐containing arm (hazard ratio = 0.64, 95% confidence interval [CI]: 0.35–1.15, p = 0.132), although the difference is not statistically significant. Summary survival curves reported the summary median PFS and overall survival were 7.9 months and 12.3 months. Subgroup analysis revealed that TKIs combined with capecitabine (TKI + Cap) regimens resulted in improved survival outcomes. Tucatinib may be more effective in BCBM patients. The main grade 3–5 adverse events (AEs) were diarrhea (22%, 95% CI: 14%–32%), neutropenia (11%, 95% CI: 5%–18%), hepatic toxicity (7%, 95% CI: 1%–16%), and sensory neuropathy (6%, 95% CI: 2%–12%).ConclusionTKIs therapy improved the survival outcomes of HER2‐positive BCBM patients, especially when combined with capecitabine and tolerable AEs. We also identified the clinical value of tucatinib, which appears to be the most favorable TKI drug for BCBM patients.