bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unlocking the Conservation Potential of Non-Timber Forest Products in Mago National Park: A Pathway to Preserving Plant Diversity in Southwest Ethiopia
Authors: Gulilat Meseret , Tilahun Abera 
Published: July 2023

Abstract
NTFP exploitation is less environmentally damaging than timber harvesting and other forest use due to this great role for plant biodiversity conservation. This study focused on type identify NTFPs and assesses the potential of NTFPs from the Mago National Park for plant diversity conservation. 15 key informants (KI) were used for listing the NTFPs bearing species collected from the park by the local communities. A parallel line transects were laid for vegetation inventory using QGIS, a total of 237 sample plots and 37 line transects were strategically placed throughout the park, covering forest, woodland, and bushland areas. The plot size 400m2 (20x20m) with nested plot. The Shannon diversity index (H’), Simpson diversity index (D) and Shannon evenness (E) were used to analyse the diversity of NTFPs bearing plant species. A total of 34 NTFPs-bearing plant species were identified. The identified NFTPs bearing plant species were categorized into eight classes based on the intended purposes for the local community. The average H’ NTFPs bearing plant species was 1.35 and E index values was 0.83. The NFTPs bearing plant species for fuelwood fodder and Honeybee more divers in park and the more available for local communities than others. NTFPs-bearing plant species more less than others study this indicate that the park plant resources faced different problems. Farther study needs to sustain NTFPs plant species.
Mineralogical characterization and environmental radiation health assessment in brick samples of Tamil Nadu
Authors: Karthikayini S. , Chandrasekaran A. 
Published: July 2023

Abstract
Natural radioactivity due to 238U, 232Th, and 40K in brick samples from Tamil Nadu was determined using gamma-ray spectrometry. The calculated mean activity concentrations of 238U, 232Th, and 40K, 69 ± 6, 62 ± 6, and 462 ± 23 Bq kg− 1, are higher than the world recommended limits of 35, 45, and 420 Bq kg− 1, respectively, and they are compared with the other countries. The calculated radiological parameters radium equivalent activity (193 ± 17 Bq kg− 1), internal hazard index (0.71 ± 0.06), activity utilization index (1.43 ± 0.13) were lower, while absorbed dose rate (89 ± 8 nGy h− 1), annual effective dose equivalent (0.43 ± 0.04 mSv y− 1) and excess lifetime cancer risk (1.52 ± 0.13 mSv y− 1), which are slightly higher than the world’s recommended limits. The minerals presented in the soil samples were identified using FT-IR and XRD techniques. Both techniques revealed that the presence of quartz, orthoclase, kaolinite, microcline, albite, illite, calcite, montmorillonite and organic carbon in the samples. Bi-variate statistical analysis was estimated to corroborate the relationship between radionuclides and radiological hazards.
Scandio-winchite, ideally ☐(NaCa)(Mg4Sc)(Si8O22)(OH)2: The first Sc-dominant amphibole-supergroup mineral from Jordanów Śląski, Lower Silesia, southwestern Poland
Authors: Pieczka Adam , Stachowicz Marcin , Zelek-Pogudz Sylwia , Gołębiowska Bożena , Sęk Mateusz , Nejbert Krzysztof , Kotowski Jakub , Marciniak-Maliszewska Beata , Szuszkiewicz Adam , Szełęg Eligiusz , Stadnicka Katarzyna M. , Woźniak Krzysztof 
Published: July 2023

Abstract
Scandio-winchite, the first natural Sc-dominant amphibole-supergroup mineral, has been discovered in a granitic pegmatite that crops out in close association with rodingite-like calc-silicate rocks and metasomatized granitic bodies in a serpentinite quarry at a Jordanów Śląski village near Sobótka, ~30 km south of Wrocław, Lower Silesia, SW Poland. It occurs as an isolated subhedral crystal, with the size of ~20 × 8 μm in planar section, and as three polycrystalline aggregates, up to 50 μm across, composed of needle-shaped crystals dominated by {110}. It is present within chlorite aggregates that supposedly represent remnants of partly recrystallized xenoliths of the blackwall chlorite schists and is in quartz-feldspar portions of the pegmatite adjoining such xenolithic assemblages. Owing to the scarcity of the material and the exceptionally small size of the crystals, the color, streak, and optical properties could not be measured. By analogy with other amphiboles, scandio-winchite has a vitreous luster, brittle tenacity, and a Mohs hardness of ~5½. The mineral shows an uneven fracture and {110} perfect cleavage, with an angle of ~56° between cleavage planes. The density calculated from the empirical formula and refined unit-cell parameters is 3.026 g/cm3. The holotype crystal is composed of (in wt%): 55.88 SiO2, 0.11 TiO2, 0.53 Al2O3, 9.22 Sc2O3, 0.44 MnO, 8.89 FeO, 12.77 MgO, 5.71 CaO, 4.12 Na2O, 0.17 K2O, and 2.09 H2Ocalc(+); total 99.93. The composition normalized on the basis of 22 O2– + 2 (OH)– ions corresponds to the empirical formula A(☐0.966K0.031Na0.003)Σ1B(Na1.132 Ca0.868)Σ2C(Mg2.704Fe1.0552+Mn0.053Sc1.140Al0.023Ti0.012)Σ4.987T(Si7.935Al0.065)Σ8.000O22(OH)2, simplified formula (☐,K)(Na,Ca)2[(Mg,Fe)4Sc](Si8O22)(OH)2, and the ideal formula ☐(NaCa)(Mg4Sc)(Si8O22)(OH)2. The crystal structure was refined in the monoclinic system, space-group symmetry C2/m, with R1 index of 6.57%. Its unit-cell parameters are: a = 9.864(2) Å, b = 18.163(3) Å, c = 5.3053(16) Å, β = 104.41(3)°, V = 920.6(4) Å3; Z = 2, and the a:b:c ratio is 0.5431:1:0.2921. The crystal-structure refinement indicates almost exclusively Si-occupied T sites, the M4 sites occupied by nearly equal amounts of Na and Ca, M1 and M3 sites by divalent Mg + Fe cations, and M2 filled in equal proportions by divalent cations and Sc. These results, along with the dominant vacancy at the A site, univocally indicate that the mineral corresponds to a M2Sc-analog of winchite. Scandio-winchite is most likely a secondary phase of metasomatic origin related to the evolution of the country rocks and partial alteration of the blackwall chlorite schists xenolith induced by the pegmatitic melt and associated fluids.
MicroRNA Profiles in Critically Ill Patients
Authors: Alikiaii Babak , Bagherniya Mohammad , Askari Gholamreza , Rajendram Rajkumar , Sahebkar Amirhossein 
Published: July 2023

:
The use of biomarkers to expedite diagnosis, prognostication, and treatment
could significantly improve patient outcomes. The early diagnosis and treatment of critical
illnesses can greatly reduce mortality and morbidity. Therefore, there is great interest
in the discovery of biomarkers for critical illnesses. Micro-ribonucleic acids (miRNAs)
are a highly conserved group of non-coding RNA molecules. They regulate the expression
of genes involved in several developmental, physiological, and pathological processes.
The characteristics of miRNAs suggest that they could be versatile biomarkers. Assay
panels to measure the expression of several miRNAs could facilitate clinical decision--
making for a range of diseases. We have, in this paper, reviewed the current understanding
of the role of miRNAs as biomarkers in critically ill patients.
Recent Advances in Research on Active Compounds Against Hepatic
Fibrosis
Authors: Liu Chuang , Li Siqi , Zhang Changhao , Jin Cheng-Hua 
Published: July 2023

Background:
Almost all chronic liver diseases cause fibrosis, which can lead to cirrhosis and eventually liver cancer. Liver fibrosis is now considered to be a reversible pathophysiological process and suppression of fibrosis is necessary to prevent liver cancer. At present, no specific drugs have been found that have hepatic anti-fibrotic activity

Objective:
The research progress of anti-hepatic fibrosis compounds in recent ten years was reviewed to provide a reference for the design and development of anti-hepatic fibrosis drugs.

Methods:
According to the structure of the compounds, they are divided into monocyclic compounds, fused-heterocyclic compounds, and acyclic compounds.

Results:
In this article, the natural products and synthetic compounds with anti-fibrotic activity in recent ten years were reviewed, with emphasis on their pharmacological activity and structure-activity relationship (SAR).

Conclusion:
Most of these compounds are natural active products and their derivatives, and there are few researches on synthetic compounds and SAR studies on natural product.
Cardiac Organoids: A 3D Technology for Disease Modeling and Drug
Screening
Authors: Zhu Yuxin , Yang Sheng , Zhang Tianyi , Ge Yiling , Wan Xin , Liang Geyu 
Published: July 2023

:
Cardiovascular diseases remain the leading cause of death worldwide; therefore,
there is increasing attention to developing physiological-related in vitro cardiovascular
tissue models suitable for personalized healthcare and preclinical test. Recently, more
complex and powerful in vitro models have emerged for cardiac research. Human cardiac
organoids (HCOs) are three-dimensional (3D) cellular constructs similar to in vivo organs.
They are derived from pluripotent stem cells and can replicate the structure, function,
and biogenetic information of primitive tissues. High-fidelity HCOs are closer to natural
human myocardial tissue than animal and cell models to some extent, which helps
to study better the development process of the heart and the occurrence of related diseases.
In this review, we introduce the methods for constructing HCOs and the application
of them, especially in cardiovascular disease modeling and cardiac drug screening. In addition,
we propose the prospects and limitations of HCOs. In summary, we have introduced
the research progress of HCOs and described their innovation and practicality of
them in the biomedical field.
The Role of Monosodium Glutamate (MSG) in Epilepsy and other
Neurodegenerative Diseases: Phytochemical-based Therapeutic
Approa-ches and Mechanisms
Authors: Singh Mansi , Panda Siva Prasad 
Published: July 2023

Abstract:
Epilepsy is a common neurological disease affecting 50 million individuals worldwide,
and some forms of epilepsy do not respond to available treatments. Overactivation of the glutamate
pathway and excessive entrance of calcium ions into neurons are proposed as the biochemical
mechanisms behind epileptic seizures. However, the overactivation of neurons has also been
associated with other neurodegenerative diseases (NDDs), such as Alzheimer's, Parkinson's, Huntington's,
and multiple sclerosis. The most widely used food ingredient, monosodium glutamate
(MSG), increases the level of free glutamate in the brain, putting humans at risk for NDDs and
epilepsy. Glutamate is a key neurotransmitter that activates nerve cells. MSG acts on glutamate
receptors, specifically NMDA and AMPA receptors, leading to an imbalance between excitatory
glutamate and inhibitory GABA neurotransmission. This imbalance can cause hyperexcitability of
neurons and lead to epileptic seizures. Overuse of MSG causes neuronal cells to become overexcited,
which in turn leads to an increase in the flow of Ca2+ and Na+ ions, mutations, and upregulation
in the enzymes superoxide dismutase 1 (SOD-1) and TDP43, all of which contribute to the
development of NDDs. While TDP43 and SOD-1 protect cells from damage, a mutation in their
genes makes the proteins unprotective and cause neurodegeneration. Yet to what extent mutant
SOD1 and TDP43 aggregates contribute to neurotoxicity is generally unknown. This study is focused
on neuroprotective herbal medications that can pass the blood-brain barrier and cure MSGinduced
NDDs and the factors that influence MSG-induced glutaminergic, astrocyte, and GABAergic
neuron abnormalities causing neurodegeneration.
Phosphate Toxicity and Vascular Calcification in Chronic Kidney Disease:
A Closer Look Utilizing Transmission Electron Microscopy
Authors: Yang Ying , Yang Ke , Xiong Yuxin , He Yusong , Zhou Yuanyuan , Hayden Melvin R. 
Published: July 2023

Abstract:
Hyperphosphatemia is independently linked with vascular calcification, cardiovascular
disease, bone-mineral disease, progression of renal insufficiency, and all-cause mortality in chronic
kidney disease (CKD) and end-stage renal disease (ESRD). The emerging importance of fibroblast
growth factor-23 (FGF-23) and its co-factor Klotho play very important roles as phosphaturic hormones;
however, phosphate levels rise due to a loss of renal Klotho production and the phosphaturic
effects of the FGF-23/Klotho axis. Hyperphosphatemia is also associated with calciphylaxis,
acceleration of renal tubulointerstitial disease, renal osteodystrophy, and uremic cardiomyopathy.
This review incorporates ultrastructural remodeling of the thoracic aorta to provide a different perspective
on vascular calcification. Nine-week-old male heterozygous (mRen2) 27 (Ren2) rat models
of hypertension, insulin resistance, vascular oxidative stress and albuminuria are utilized to demonstrate
aortic remodeling associated with vascular calcification. Nine-week-old male Zucker
obese (fa/fa) rat models are utilized to better understand nephrolith formation. Phosphate homeostasis,
toxicity, multiple metabolic and uremic toxicities, renal osteodystrophy, and vascular calcification
are also discussed. Additionally, the role of the endothelium, vascular smooth muscle cells, inflammatory
monocytes/macrophages and mast cells, pericytes, oxidative stress, hydrogen sulfide,
and extraosseous calcification in the kidney are discussed as they relate to CKD, ESRD and calciphylaxis.
Recent Literature on the Synthesis of Thiazole Derivatives and their
Biological Activities
Authors: Farghaly Thoraya A. , Alfaifi Ghaidaa H. , Gomha Sobhi M. 
Published: July 2023

Abstract:
The thiazole ring is naturally occurring and is primarily found in marine and microbial
sources. It has been identified in various compounds such as peptides, vitamins (thiamine), alkaloids,
epothilone, and chlorophyll. Thiazole-containing compounds are widely recognized for their antibacterial,
antifungal, anti-inflammatory, antimalarial, antitubercular, antidiabetic, antioxidant, anticonvulsant,
anticancer, and cardiovascular activities. The objective of this review is to present recent advancements
in the discovery of biologically active thiazole derivatives, including their synthetic
methods and biological effects. This review comprehensively discusses the synthesis methods of thiazole
and its corresponding biological activities within a specific timeframe, from 2017 until the conclusion
of 2022.
A Narrative Review of Signaling Pathway and Treatment Options for Diabetic Nephropathy
Authors: Bhupesh Semwal , Chauhan Neha , Jyoti Verma , Ankit Kumar , Sonia Singh , Bhupendra Singh 
Published: July 2023

Background:
Diabetic nephropathy is a progressive kidney disease that
frequently results in end-stage renal disorders and is characterized by proteinuria,
albuminuria, decreased filtration, and renal fibrosis. Despite the fact that there are a
number of therapeutic alternatives available, DN continues to be the main contributor to
end-stage renal disease. Therefore, significant innovation is required to enhance
outcomes in DN patients.

Methods:
Information was collected from online search engines like, Google Scholar,
Web of Science, PubMed, Scopus, and Sci-Hub databases using keywords like
diabetes, nephropathy, kidney disease, autophagy, etc.

Results:
Natural compounds have anti-inflammatory and antioxidant properties and
impact various signaling pathways. They ameliorate kidney damage by decreasing
oxidative stress, inflammatory process, and fibrosis and enhance the antioxidant system,
most likely by activating and deactivating several signaling pathways. This review
focuses on the role of metabolic memory and various signaling pathways involved in the
pathogenesis of DN and therapeutic approaches available for the management of DN.
Special attention is given to the various pathways modulated by the phytoconstituents.
Quorum Sensing in Gram-Negative Bacteria: Strategies to
Overcome Antibiotic Resistance in Ocular Infections
Authors: Tiwari Sakshi , Gidwani Bina , Vyas Amber 
Published: July 2023

Abstract:
Truly miraculous medications and antibiotics have helped save untold millions
of lives. Antibiotic resistance, however, is a significant issue related to health that
jeopardizes the effectiveness of antibiotics and could harm everyone's health. Bacteria,
not humans or animals, become antibiotic-resistant. Bacteria use quorum-sensing
communication routes to manage an assortment of physiological exercises. Quorum
sensing is significant for appropriate biofilm development. Antibiotic resistance occurs
when bacteria establish a biofilm on a surface, shielding them from the effects of
infection-fighting drugs. Acylated homoserine lactones are used as autoinducers by
gram-negative microscopic organisms to impart. However, antibiotic resistance among
ocular pathogens is increasing worldwide. Bacteria are a significant contributor to ocular
infections around the world. Gram-negative microscopic organisms are dangerous to
ophthalmic tissues. This review highlights the use of elective drug targets and
treatments, for example, combinational treatment, to vanquish antibiotic-resistant
bacteria. Also, it briefly portrays anti-biotic resistance brought about by gram-negative
bacteria and approaches to overcome resistance with the help of quorum sensing
inhibitors and nanotechnology as a promising medication conveyance approach to give
insurance of anti-microbials and improve pathways for the administration of inhibitors of
quorum sensing with a blend of anti-microbials to explicit target destinations and
penetration through biofilms for treatment of ocular infections. It centres on the
methodologies to sidestep the confinements of ocular anti-biotic delivery with new visual
innovation.
Advances in Small Molecules of Flavonoids for the Regulation of
Gluconeogenesis
Authors: Wu Xiaoran , Wang Aidong , Ning Chuchu , Wu Yangyang , Chen Sunhui 
Published: July 2023

Abstract:
Hyperglycemia resulting from over-gluconeogenesis is a prominent feature of type 2 dia-betes mellitus (T2DM). Therefore, it is very important to reduce glucose output, especially liver glucose output, and maintain blood glucose homeostasis in the treatment of T2DM. It has been found that small molecules of natural flavonoids are able to act on various targets in the gluconeo-genic pathways, interfering with rate-limiting enzyme activity or regulating the cascade of hormonal signaling and affecting all levels of transcription factors by limiting the transport of non-sugar sub-strates. As a result, gluconeogenesis is inhibited. Literature indicated that gluconeogenesis regulated by flavonoids could be divided into two pathways, namely the pre-translational pathway and the pro-translational pathway. The pre-translational pathway mainly interferes with the signaling path-way and transcription factors in gluconeogenesis and inhibits RNA transcription and the expression of gluconeogenic genes, while the post-translational pathway mainly regulates the transport of non-glucose substrates and directly inhibits four rate-limiting enzymes. This review describes the effects of small flavonoid molecules on different targets and signaling pathways during gluconeogenesis, as well as relevant validation methods, in the hope of providing references for similar studies and promoting the development of anti-diabetic drugs.
In silico Pharmacodynamics, Antineoplastic Activity and Molecular Docking of two Phytochemicals Isolated from Thymelaea microphylla
Authors: Ghanem Hasna , Khaoua Oussama , Ouahab Ammar , Benbellat Noura , Haba Hamada 
Published: July 2023

Background:
The lead compounds isolated from medicinal plants constitute a matrix for
research and discovery of new drugs using in silico study and molecular docking.

Objective:
This work explores the in silico study and the molecular docking of two rare phytochemicals,
namely Microphynolide A (1) and Microphynolide B (2), isolated from the Saharan medicinal plant
Thymelaea microphylla (Thymelaeaceae family).

Methods:
In the current work, several integrated web-based in silico pharmacokinetic tools were used to
estimate the druggability of two isolated phytochemicals. In addition, molecular docking was conducted
using AutoDockVina 4.2 to study the binding interactions with the targets predicted employing the
PharmMapper server. The toxicological study was evaluated using ProTox-II online server. DFT methods
were utilized to evaluate some physicochemical properties of structures, vibrational wavenumbers, and
molecular electrostatic potentials.

Results:
Molecules (1) and (2) showed good ADMET profiles and antineoplastic activity. Also, they
exhibited non-toxicity and belong to the Toxicity class VI (LD50 >8000 mg/kg) with immunotoxic
activity. A good correlation was observed between the experimental and theoretical IR spectra, with no
negative values in the theoretical spectra indicating the high stability of these compounds. Docking
simulation studies against protein receptors Sulfotransferase 1A1 (PDB ID: 1LS6) and Angiogenin (PDB
ID: 1B1I) displayed good binding affinity values of -5.8 and -6.8 kcal/mol, respectively, with number of
H-bonding interactions. Furthermore, the control molecules p-Nitrophenol (pNP), Dopamine, Axitinib
and Bevacizumab displayed values of binding energies of -6.7, -6.7, -6.9 and -6.3 Kcal/mol, respectively.

Conclusion:
This study provides evidence supporting that the two molecules could be effective drugs to
inhibit cancer cells and did not show any acute toxicity or mutagenic effects.
Appraisal of Cardiovascular Risk Factors, Biomarkers, and Ocular
Imaging in Cardiovascular Risk Prediction
Authors: Moore Julie S. , Nesbit M. Andrew , Moore Tara 
Published: July 2023

Abstract:
Cardiovascular disease remains a leading cause of death worldwide despite the use of
available cardiovascular disease risk prediction tools. Identification of high-risk individuals via risk
stratification and screening at sub-clinical stages, which may be offered by ocular screening, is important
to prevent major adverse cardiac events. Retinal microvasculature has been widely researched
for potential application in both diabetes and cardiovascular disease risk prediction. However,
the conjunctival microvasculature as a tool for cardiovascular disease risk prediction remains
largely unexplored. The purpose of this review is to evaluate the current cardiovascular risk assessment
methods, identifying gaps in the literature that imaging of the ocular microcirculation
may have the potential to fill. This review also explores the themes of machine learning, risk
scores, biomarkers, medical imaging, and clinical risk factors. Cardiovascular risk classification
varies based on the population assessed, the risk factors included, and the assessment methods. A
more tailored, standardised and feasible approach to cardiovascular risk prediction that utilises
technological and medical imaging advances, which may be offered by ocular imaging, is required
to support cardiovascular disease prevention strategies and clinical guidelines.