bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interactions between potassium ashes and oxygen carriers based on natural and waste materials at different initial oxidation states
Authors: Purnomo Victor , Hildor Fredrik , Knutsson Pavleta , Leion Henrik 
Published: March 2023

AbstractOne of the most essential features of an oxygen carrier is its ability to be oxidized and reduced in order to transfer oxygen in a chemical looping system. A highly reduced oxygen carrier can experience multiple performance issues, such as decreased reactivity, agglomeration, and defluidization. This is crucial for processes that require limited oxygen transfer from the air reactor to the fuel reactor. Meanwhile, biomasses as environmentally friendly fuel options contain ashes, which would inevitably react with oxygen carriers and exacerbate the performance issues. To mimic the interactions between a highly reduced oxygen carrier and biomass ash compounds, four iron‐based oxygen carriers, based on natural ores and waste materials, and three potassium salts, K2CO3, KH2PO4, and K2SO4, were investigated in a tubular reactor under an atmosphere consisting of 2.5% H2 and 10% steam in Ar and N2 at 900°C for 3 h. The results from the X‐ray diffraction (XRD) material analysis showed that both initially fully oxidized and highly reduced materials reach the same oxidation state after the experiment. Based on the scanning electron microscopy coupled with energy dispersive X‐ray spectroscopy results, K from K2CO3 and K2SO4 diffuses in the oxygen carrier particles, while K from KH2PO4 always forms a distinct layer around the particles. The initial oxidation state of an oxygen carrier surface affects the interactions with the potassium salt only to minor extents. Thus, the final state of the material and its performance in a large‐scale process are only occasionally and mildly affected by its initial oxidation state. © 2023 The Authors. Greenhouse Gases: Science and Technology published by Society of Chemical Industry and John Wiley & Sons Ltd.
BSSE‐corrected consistent Gaussian basis sets of triple‐zeta valence quality of the lanthanides La‐Lu for solid‐state calculations
Authors: Seidler Leopold Maximilian , Laun Joachim , Bredow Thomas 
Published: March 2023

AbstractConsistent basis sets of triple‐zeta valence quality for the elements La‐Lu were derived for periodic quantum‐chemical solid‐state calculations. They are an extension of the pob‐TZVP‐rev2 [D. Vilela Oliveira, et al., J. Comput. Chem. 2019, 40(27), 2364–2376], [J. Laun and T. Bredow, J. Comput. Chem. 2021, 42(15), 1064–1072], [J. Laun and T. Bredow, J. Comput. Chem. 2022, 43(12), 839–846] basis sets and are based on the fully relativistic effective core potentials of the Stuttgart/Cologne group and on the def2‐TZVP valence basis of the Ahlrichs group. The basis sets are constructed to minimize the basis set superposition error in crystalline systems. The contraction scheme, orbital exponents, and contraction coefficients were optimized in order to ensure robust and stable self‐consistent‐field convergence for a set of compounds and metals. For the applied PW1PW hybrid functional, the average deviations of the calculated lattice constants from experimental references are smaller with pob‐TZV‐rev2 than with standard basis sets available from the CRYSTAL basis set database. After augmentation with single diffuse s‐ and p‐functions, reference plane‐wave band structures of metals can be accurately reproduced.
Aluminabenzene‐based Lewis superacids and weakly coordinating anions
Authors: Brzeski Jakub 
Published: March 2023

AbstractQuantum‐chemical calculations were used to describe both the acidity of aluminabenzene‐based Lewis acids and stability of aluminabenzene‐based anions. Aluminabenzene itself was found to exhibit greater acidity than antimony pentaflouride, and thus can be qualified as a Lewis superacid. Substitution of the heterocyclic ring with electron withdrawing groups results in formation of extremely strong Lewis superacids. Two of them, namely AlC5Cl5 and AlC5(CN)5 are the strongest Lewis acids described in the literature so far. Whereas, anions formed after the addition of fluoride anion to substituted aluminabenzene‐based Lewis acids, while characterized by somewhat lower electronic stability than the least coordinating anions hitherto known, are considerably more stable in terms of thermodynamic stability (measured by the propensity to electrophile attack). On this account they are expected to act as counterions for the most reactive cations. The proposed Lewis acids may be prone to the isomerization and dimerization, whereas studied anions are expected to be stable with regard to such processes.
The importance of acculturation orientation in understanding the impact of pre‐ and post‐migration stressors on behavioral health: Evidence from a crisis migrant sample
Authors: Salas‐Wright Christopher P. , Vaughn Michael G. , Maldonado‐Molina Mildred M. , Bates Melissa , Brown Eric C. , García María F. , Rodríguez José , Schwartz Seth J. 
Published: March 2023

AbstractObjectiveWe examine the interplay of acculturation orientation, cultural stress, and hurricane trauma exposure with behavioral health among Puerto Rican crisis migrants who relocated to the US mainland after Hurricane Maria.MethodParticipants were 319 adult (Mage = 39 years; 71% female; 90% arriving in 2017−2018) Hurricane Maria survivors surveyed on the US mainland. Latent profile analysis was used to model acculturation subtypes. In turn, ordinary least squares regression was executed to examine the associations of cultural stress and hurricane trauma exposure with behavioral health while stratifying by acculturation subtype.ResultsFive acculturation orientation subtypes were modeled, three of which—Separated (24%), Marginalized (13%), and Full Bicultural (14%)—align closely with prior theorizing. We also identified Partially Bicultural (21%) and Moderate (28%) subtypes. Stratifying by acculturation subtype, with behavioral health (depression/anxiety symptoms) specified as the dependent variable, hurricane trauma and cultural stress accounted for only 4% of explained variance in the Moderate class, a somewhat greater percentage in the Partial Bicultural (12%) and Separated (15%) classes, and substantially greater amounts of variance in the Marginalized (25%) and Full Bicultural (56%) classes.ConclusionFindings underscore the importance of accounting for acculturation in understanding the relationship between stress and behavioral health among climate migrants.
NiO/MoO2/MoO3 prepared by normal pulse voltammetry as cathode catalysts to investigate the properties of microbial electrolysis cells
Authors: Zhang Wusheng , Zhao Yu , Zhang Jie , Chen Shuwei 
Published: March 2023

AbstractBACKGROUNDA microbial electrolysis cell (MEC) is a bio‐hydrogen production device that uses electrochemically active bacteria on the anode combined with applied voltage to break down organic matter. However, the effects of element content on cathode reduction and cathode catalysts on bioanode activity remain unknown.RESULTSMEC cathodes with different content of Na2MoO4·2H2O (i.e. 0 g L−1 (Ni), 12.5 g L−1 (Ni–Mo 1), 25 g L−1 (Ni–Mo 2) and 37.5 g L−1 (Ni–Mo 3)) were fabricated by normal pulse voltammetry to evaluate the cathode performance. Nanoparticles of Ni electrode are crystalline NiO on the carbon fiber surface. Compared with the Ni electrode, the catalysts of Ni–Mo electrodes are composed of smaller crystalline NiO and amorphous Mo oxides. The results of electrochemical analysis confirmed that Ni–Mo 1 exhibited low exchange transfer resistance (148.72 Ω), high electrochemically active surface area and strong conductivity, resulting in optimal electrocatalysis performance. The newly fabricated electrodes are applied as cathodes in single‐chamber MEC reactors and inoculated with activated sludge from a municipal wastewater treatment plant. High peak current density determined using cyclic voltammetry of the bioanode indicated the strong electrochemical activity of electroactive bacteria in the bioanode of Ni–Mo 1. This is because the low resistance in the MECs could accelerate electron transfer and boost electrochemical reaction.CONCLUSIONSThe performance of cathodes with different Ni and Mo content in terms of electrochemical activity was evaluated. Consequently, the optimal cathode electrode in MECs was Ni–Mo 1. The obtained results reveal that the cathode affects the bioanode activity in MECs. © 2023 Society of Chemical Industry (SCI).
WDR3 promotes stem cell‐like properties in prostate cancer by inhibiting USF2‐mediated transcription of RASSF1A
Authors: Liu Weijing , Xie An , Xiong Jing , Li Sheng , Yang Lin , Liu Weipeng 
Published: March 2023

AbstractBackgroundWD repeat domain 3 (WDR3) is involved in tumor growth and proliferation, but its role in the pathological mechanism of prostate cancer (PCa) is still unclear.MethodsWDR3 gene expression levels were obtained by analyzing databases and our clinical specimens. The expression levels of genes and proteins were determined by a real‐time polymerase chain reaction, western blotting and immunohistochemistry, respectively. Cell‐counting kit‐8 assays were used to measure the proliferation of PCa cells. Cell transfection was used to investigate the role of WDR3 and USF2 in PCa. Fluorescence reporter and chromatin immunoprecipitation assays were used to detect USF2 binding to the promoter region of RASSF1A. Mouse experiments were used to confirm the mechanism in vivo.ResultsBy analyzing the database and our clinical specimens, we found that WDR3 expression was significantly increased in PCa tissues. Overexpression of WDR3 enhanced PCa cell proliferation, decreased cell apoptosis rate, increased spherical cell number and increased indicators of stem cell‐like properties. However, these effects were reversed by WDR3 knockdown. WDR3 was negatively correlated with USF2, which was degraded by promoting ubiquitination of USF2, and USF2 interacted with promoter region‐binding elements of RASSF1A to depress PCa stemness and growth. In vivo studies showed that WDR3 knockdown reduced tumor size and weight, reduced cell proliferation and enhanced cell apoptosis.ConclusionsWDR3 ubiquitinated USF2 and inhibited its stability, whereas USF2 interacted with promoter region‐binding elements of RASSF1A. USF2 transcriptionally activated RASSF1A, which inhibited the carcinogenic effect of WDR3 overexpression.
Acquired hemophilia A (AHA) due to anti‐SARS‐CoV‐2 vaccination: A systematic review
Authors: Amisha Fnu , Saluja Prachi , Malik Paras , Van Rhee Frits 
Published: March 2023

AbstractVaccination against SARS‐CoV2 has been the largest vaccination campaign over the past two decades. The aim of this study is to qualitatively assess the reported cases of acquired hemophilia A (AHA) that developed after COVID‐19 vaccination to further elaborate on incidence, presentation, treatment, and outcomes.We queried Medline (PubMed), Google Scholar, and Embase databases to find reported cases of AHA after COVID‐19 vaccines. We found 14 studies (19 cases) for this descriptive analysis. Most patients were elderly (mean age 73 years) and males (n = 12) with multiple comorbidities. All cases developed after mRNA vaccines ‐ BNT162b2 Pfizer‐BioNTech (n = 13) and mRNA‐1273 Moderna (n = 6). All except one patient were treated, with the most common therapy being a combination of steroids, immunosuppression, and rFVIII (n = 13). Two patients died due to acute respiratory distress, and gall bladder rupture with persistent bleeding, respectively. While evaluating a patient with bleeding diathesis after COVID‐19 vaccination, AHA should be kept in the differential diagnosis. Given the low incidence, we believe that the benefit of vaccination still outweighs the risk of disease acquisition.
Viruses and phospholipids: Friends and foes during infection
Authors: Rattay Stephanie , Hufbauer Martin , Hoboth Peter , Sztacho Martin , Akgül Baki 
Published: March 2023

AbstractViruses have evolved complex and dynamic interactions with their host cells to enable viral replication. In recent years, insights have been gained into the increasingly important role of the host cell lipidome in the life cycle of several viruses. In particular, viruses target phospholipid signaling, synthesis, and metabolism to remodel their host cells into an optimal environment for their replication cycle. Conversely, phospholipids and their associated regulatory enzymes can interfere with viral infection or replication. This review highlights examples of different viruses that illustrate the importance of these diverse virus–phospholipid interactions in different cellular compartments, particularly the role of nuclear phospholipids and their association with human papillomavirus (HPV)‐mediated cancer development.
ORF45, a multifunctional immediate early and tegument protein of KSHV
Authors: Liang Qiming , Zhu Fanxiu 
Published: March 2023

AbstractKaposi sarcoma‐associated herpesvirus (KSHV) is the etiological agent of several human diseases, including Kaposi sarcoma, primary effusion lymphoma, and a subset of multicentric Castleman's disease. KSHV uses its gene products to manipulate many aspects of the host responses during its life cycles. Among KSHV‐encoded proteins, ORF45 is unique in both temporal and spatial expression: it is expressed as an immediate‐early gene product and is an abundant tegument protein contained in the virion. ORF45 is specific to the gammaherpesvirinae subfamily but the homologs share only very limited homology and differ dramatically in protein length. In the past two decades, we and others have shown that ORF45 plays critical roles in immune evasion, viral replication, and virion assembly by targeting various host and viral factors. Herein, we summarize our current knowledge of ORF45 throughout the KSHV life cycle. We discuss the cellular processes targeted by ORF45 with emphasis on the modulation of host innate immune responses and rewiring the host signaling through impacting three major posttranslational modifications: phosphorylation, SUMOylation, and ubiquitination.
Risk of hospitalization and sequelae in patients with COVID‐19 treated with 3‐day early remdesivir vs. controls in the vaccine and Omicron era: A real‐life cohort study
Authors: Mazzitelli Maria , Trunfio Mattia , Sasset Lolita , Scaglione Vincenzo , Ferrari Anna , Mengato Daniele , Gardin Samuele , Bonadiman Nicola , Calandrino Lucrezia , Agostini Elena , Cattelan Anna Maria 
Published: March 2023

AbstractRecently, a benefit from administration of a 3‐day course of early remdesivir (ER) in the outpatients' setting was reported. However, real‐life data on its use is scarce. Therefore, we explored the ER clinical outcome in our outpatients' s cohort, compared to untreated controls. We included all patients who were prescribed ER from February to May 2022 and followed them up for 3 months and compared patients who received treatment with untreated controls. In the two groups the following outcomes were investigated: hospitalization and mortality rate, time of negativization and symptom's resolution, and postacute coronavirus disease 19 (COVID‐19) syndrome prevalence. Overall, 681 patients were analyzed, mostly females (53.6%), and with a median age of 66 years (interquartile range: 54–77), 316 (46.4%) patients received ER, and 365 (53.6%) did not receive antiviral treatment (control group). Overall, 8.5% patients eventually required oxygen support, 8.7% were hospitalized for COVID‐19, and 1.5% died. Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) immunization and ER (adjusted odds ratio [aOR]: 0.049 [0.015; 0.16], p < 0.001) independently reduced hospitalization risk. ER was significantly associated with a shorter duration of SARS‐CoV‐2 positivity at nasopharyngeal swabs (aβ −8.15 [−9.21; −7.09], p < 0.001) and of symptoms (aβ −5.11 [−5.82; −4.39], p < 0.001), and with lower rate of COVID‐19 sequelae compared to control group (aOR: 0.18 [0.10; 0.31], p < 0.001). Even in the SARS‐CoV‐2 vaccination and Omicron era, in patients at high risk of developing severe disease, ER demonstrated to have a good safety profile and to significantly reduce the risk of disease progression and COVID‐19 sequelae compared to untreated controls.
Evaluation of analgesic and prophylactic activity of curcumin against chikungunya‐infected acute/chronic arthralgic mice
Authors: Sengupta Siddhartha , Tripathi Anusri 
Published: March 2023

AbstractChikungunya virus (CHIKV) infection, a global public health problem, might lead to acute/chronic polyarthritis causing long‐term morbidity among infected patients. But, except nonsteroidal anti‐inflammatory drugs (NSAIDs) with gastrointestinal, cardiovascular, and immune‐related side‐effects, no Food and Drug Administration (FDA)‐approved analgesic drug is available till date for the treatment of CHIKV‐induced arthritis. Curcumin, a plant product with minimal toxicity has been FDA‐approved as a Generally Recognized As Safe drug. This study aimed to determine the analgesic and prophylactic effect of curcumin, if any, among CHIKV‐induced arthralgic mice. Arthritic pain was evaluated by von Frey assay, locomotory behavior by open‐field test, and feet swelling by calipers. Cartilage integrity and proteoglycan loss were evaluated by Safranin O staining followed by Osteoarthritis Research Society International (OARSI), Standardized Microscopic Arthritis Scoring of Histological sections (SMASH) score, and type II collagen loss by immunohistochemistry. Mice were administered high (HD), mid (MD), and low (LD) curcumin doses, before (PT: pretreatment), during (CT: cotreatment) and after (Post‐T: posttreatment) CHIKV‐infection. Curcumin treatment using PTHD (2000 mg/kg), CTHD, and Post‐TMD (1000 mg/kg) significantly alleviated CHIKV‐induced arthritic pain by improving pain‐threshold, locomotory behavior and reducing feet swelling of infected mice. Also, decreased proteoglycan loss and cartilage erosion with lower OARSI, SMASH scores were observed among these three subgroups compared to infected ones. Compared to infected ones, one‐ to twofold increased intensity of type II collagen in knee medial femoral condyle and medial tibial plateau regions of these subgroups was observed by immunohistochemical staining. Thus, this study highlighted both the analgesic (CT, Post‐T), and prophylactic (PT) activity of curcumin in alleviating CHIKV‐induced acute/chronic arthritis within mouse model.
Stable and durable antibody responses in SARS‐recovered donors vaccinated with inactivated SARS‐CoV‐2 vaccine
Authors: Jia Tingting , Wu Yuankai , Liao Guancheng , Lei Yuxuan , Wu Zhengyu , Yang Fangji , Chen Jiamin , Xie Qian , Luo Chuming , Chong Yutian , Luo Huanle , Shu Yuelong 
Published: March 2023

AbstractWhether the immune imprinting caused by severe acute respiratory syndrome coronavirus (SARS‐CoV) affects the efficiency of SARS‐CoV‐2 vaccination has attracted global concern. Little is known about the dynamic changes of antibody response in SARS convalescents inoculated with three doses of inactivated SARS‐CoV‐2 vaccine although lack of cross‐neutralizing antibody response to SARS‐CoV‐2 in SARS survivors has been reported. We longitudinally examined the neutralizing antibodies (nAbs) against SARS‐CoV and SARS‐CoV‐2 as well as spikes binding IgA, IgG, IgM, IgG1, and IgG3 antibodies in 9 SARS‐recovered donors and 21 SARS‐naïve donors. Stably higher nAbs and spike antigens‐specific IgA, IgG antibodies against SARS‐CoV‐2 were observed in SARS‐recovered donors compared with SARS‐naïve donors during the period with two doses of BBIBP‐CorV vaccination. However, the third‐dose BBIBP‐CorV stimulated a sharply and shortly higher increase of nAbs in SARS‐naïve donors than in SARS‐recovered donors. It is worth noting that, regardless of prior SARS infection, the Omicron subvariants were found to subvert immune responses. Moreover, certain subvariants such as BA.2, BA.2.75, or BA.5 exhibited a high degree of immune evasion in SARS survivors. Interestingly, BBIBP‐CorV recalled higher nAbs against SARS‐CoV compared with SARS‐CoV‐2 in SARS‐recovered donors. In SARS survivors, a single dose of inactivated SARS‐CoV‐2 vaccine provoked immune imprinting for the SARS antigen, providing protection against wild‐type SARS‐CoV‐2, and the earlier variants of concern (VOCs) including Alpha, Beta, Gamma, and Delta but not against Omicron subvariants. As such, it is important to evaluate the type and dosage of SARS‐CoV‐2 vaccine for SARS survivors.
Characterization of hepatitis virus co‐infections in a cohort of immigrants living in southern Italy
Authors: Pisaturo Mariantonietta , Alessio Loredana , Starace Mario , Macera Margherita , Occhiello Laura , Cordua Emanuele , Capuano Salvatore , Onorato Lorenzo , Scotto Gaetano , Di Caprio Giovanni , Calò Federica , Monari Caterina , Sagnelli Caterina , Coppola Nicola 
Published: March 2023

AbstractTo characterize viral hepatitis co‐infections in a cohort of immigrants living in southern Italy. In a prospective multicenter study, all undocumented immigrants and low‐income refugees consecutively evaluated for a clinical consultation at one of the five first‐level clinical centers in southern Italy from January 2012 to February 2020 were enrolled. All subjects included in the study were screened for hepatitis B surface antigen (HBsAg), anti‐hepatitis C virus (HCV) and anti‐HIV; the HBsAg‐positive were screened also for anti‐delta. Of the 2923 subjects enrolled, 257 (8%) were HBsAg‐positive alone (Control group B), 85 (2.9%) only anti‐HCV‐positive (Control group C), 16 (0.5%) HBsAg/anti‐HCV‐positive (Case group BC), and 8 (0.2%) HBsAg/anti‐HDV‐positive (Case group BD). Moreover, 57 (1.9%) subjects were anti‐HIV‐positive. HBV‐DNA positivity was found less frequently in the 16 subjects in Case group BC (43%) and in the 8 in Case group BD (12.5%) than in the 257 in Control group B (76%; p = 0.03 and 0.0000, respectively). Similarly, HCV‐RNA positivity was more frequent in Case group BC than in Control group C (75% vs. 44.7% p = 0.02). The subjects in Group BC had a lower prevalence of asymptomatic liver disease (12.5%) than Control group B (62.2%, p = 0.0001) and Control group C (62.3%, p = 0.0002). Conversely, liver cirrhosis was more frequently identified in Case group BC (25%) than in Control groups B and C (3.11% and 2.35%, p = 0.0000 and 0.0004, respectively). The present study contributes to the characterization of hepatitis virus co‐infections in the immigrant population.