bluuebunny/crossref_metadata_2025_split huggingface dataset:
OSTRACISMO ENTRE ENFERMEIROS EM AMBIENTE HOSPITALAR: UMA REVISÃO SISTEMÁTICA
Authors: Sabino Paulo Jorge Rodrigues 
Published: August 2023

Enquadramento: O ostracismo no local de trabalho (OLT) entre enfermeiros é um fenómeno atual, com conotação negativa, que pode afetar seriamente o equilíbrio social, emocional e laboral do profissional de enfermagem. Objetivo: Obter e analisar a evidência científica existente sobre a temática do ostracismo entre enfermeiros em ambiente hospitalar. Metodologia: Revisão sistemática da literatura (RSL), com análise de artigos publicados entre 2018 e 2023 nas bases B-ON, EBSCO, PMC e PubMed, com descritores MeSH e DeCS, sendo selecionados 4 artigos. Resultados: Os estudos evidenciaram que o OLT afeta, negativamente e de forma efetiva, vários fatores associados ao profissional de enfermagem, destacando-se a interação social, a exaustão emocional ou a ineficiência laboral. Conclusões: Ficou claro que o OLT, sendo de difícil identificação e caraterização, apresenta uma estreita ligação ao perfil social e emocional de cada profissional de enfermagem, condiciona comportamentos e atitudes, a partir de fatores potenciadores e atenuantes, e pode levar a situações de incumprimento laboral, de burnout e de abandono precoce da profissão.
Anthropogenic activities significantly increase annual greenhouse gas (GHG) fluxes from temperate headwater streams in Germany
Authors: Mwanake Ricky Mwangada , Gettel Gretchen Maria , Wangari Elizabeth Gachibu , Glaser Clarissa , Houska Tobias , Breuer Lutz , Butterbach-Bahl Klaus , Kiese Ralf 
Published: August 2023

Abstract. Anthropogenic activities increase the contributions of inland waters to
global greenhouse gas (GHG; CO2, CH4, and N2O) budgets, yet
the mechanisms driving these increases are still not well constrained. In
this study, we quantified year-long GHG concentrations, fluxes, and water
physico-chemical variables from 28 sites contrasted by land use across five
headwater catchments in Germany. Based on linear mixed-effects models, we
showed that land use was more significant than seasonality in controlling
the intra-annual variability of the GHGs. Streams in agriculture-dominated
catchments or with wastewater inflows had up to 10 times higher daily
CO2, CH4, and N2O emissions and were also more temporally
variable (CV > 55 %) than forested streams. Our findings also
suggested that nutrient, labile carbon, and dissolved GHG inputs from the
agricultural and settlement areas may have supported these hotspots and
hot-moments of fluvial GHG emissions. Overall, the annual emission from
anthropogenic-influenced streams in CO2 equivalents was up to 20 times
higher (∼ 71 kg CO2 m−2 yr−1) than from
natural streams (∼ 3 kg CO2 m−2 yr−1), with
CO2 accounting for up to 81 % of these annual emissions, while
N2O and CH4 accounted for up to 18 % and 7 %, respectively. The
positive influence of anthropogenic activities on fluvial GHG emissions also
resulted in a breakdown of the expected declining trends of fluvial GHG
emissions with stream size. Therefore, future studies should focus on
anthropogenically perturbed streams, as their GHG emissions are much more
variable in space and time and can potentially introduce the largest
uncertainties to fluvial GHG estimates.
Modelling the development and decay of cryoconite holes in northwestern Greenland
Authors: Onuma Yukihiko , Fujita Koji , Takeuchi Nozomu , Niwano Masashi , Aoki Teruo 
Published: August 2023

Abstract. Cryoconite holes (CHs) are water-filled cylindrical holes with cryoconite (dark-coloured sediment) deposited at their bottoms, forming on ablating
ice surfaces of glaciers and ice sheets worldwide. Because the collapse of CHs may disperse cryoconite on the ice surface, thereby decreasing the
ice surface albedo, accurate simulation of the temporal changes in CH depth is essential for understanding ice surface melt. We established a novel
model that simulates the temporal changes in CH depth using heat budgets calculated independently at the ice surface and CH bottom based on
hole-shaped geometry. We evaluated the model with in situ observations of the CH depths on the Qaanaaq ice cap in northwestern Greenland during the
2012, 2014, and 2017 melt seasons. The model reproduced the observed depth changes and timing of CH collapse well. Although earlier models have
shown that CH depth tends to be deeper when downward shortwave radiation is intense, our sensitivity tests suggest that deeper CH tends to form when
the diffuse component of downward shortwave radiation is dominant, whereas CHs tend to be shallower when the direct component is dominant. In
addition, the total heat flux to the CH bottom is dominated by shortwave radiation transmitted through ice rather than that directly from the
CH mouths when the CH is deeper than 0.01 m. Because the shortwave radiation transmitted through ice can reach the CH bottom regardless of
CH diameter, CH depth is unlikely to be correlated with CH diameter. The relationship is consistent with previous observational
studies. Furthermore, the simulations highlighted that the difference in albedo between ice surface and CH bottom was a key factor for reproducing
the timing of CH collapse. It implies that lower ice surface albedo could induce CH collapse and thus cause further lowering of the albedo. Heat
component analysis suggests that CH depth is governed by the balance between the intensity of the diffuse component of downward shortwave radiation
and the turbulent heat transfer. Therefore, these meteorological conditions may be important factors contributing to the recent surface darkening of
the Greenland ice sheet and other glaciers via the redistribution of CHs.
PELATIHAN PRAKTIKUM IPA BERBAHAN LINGKUNGAN SEKITAR PADA GURU IPA SMP KABUPATEN MAROS
Authors: Nur Amaliah Akhmad  , Andi Nur Samsi  , Fandi Ahmad  , Surahman Nur  , St. Humaerah Syarif  , Rusmidin  
Published: August 2023

Pelatihan praktikum untuk guru IPA berbasis lingkungan bertujuan untuk melatih guru dalam mengembangkan kreativitas dalam menciptakan alat peraga sederhana yang ada di lingkungan. Pelaksanakan Pelatihan ini ada 4 tahap yakni survey, pelaksanaan, pendampingan dan evaluasi pelatihan. Survey dilaksanakan pada kelompok guru MGMP IPA Kabupaten Maros dan menganalisa kesulitan yang dihadapi guru selama pandemi Covid-19 ini. Guru diberikan pelatihan menciptakan praktikum sederhana berbasis lingungan agar mampu digunakan oleh guru dan siswa selama pandemi tanpa harus masuk ke laboratorium. Setelah pelatihan, guru-guru didampingi selama 2 minggu untuk melihat kendala yang dihadapi guru. Proses evaluasi bertujuan melihat sejauh mana kemampuan guru berkreativitas dalam mengembangkan alat peraga berbasis lingkungan ini. Hasil dari kegiatan ini didapatkan bahwa guru semakin terampil dalam mengolah dan menciptakan praktikum sederhana berbasis lingkungan sehingga memudahkan proses pembelajaran IPA selama pandemi ini berlangsung
ESCOLA QUEERSTIONADORA: Por um currículo que problematize as supostas estruturas de gênero e sexualidade
Authors: Rezende Graziela Pinho , Amim Valéria 
Published: August 2023

Ainda que não se discuta a respeito da diversidade de gênero e sexualidade de maneira aberta na escola, ela está presente no cotidiano dos estudantes, nos diálogos e na demarcação dos espaços físicos dessa instituição. Entretanto, ao analisarmos como os documentos norteadores do currículo citam tais questões, desde os Parâmetros Curriculares Nacionais (PCN) à Base Nacional Comum Curricular (BNCC), percebemos a prevalência da ideologia de um regime de dominação que contribui para o amoldamento da escola aos modelos hegemônicos, inviabilizando e marginalizando todos aqueles que não se encaixam no padrão cis-heteropatriarcal. Assim, o currículo também é um espaço de poder, de autoridade e de disputas ideológicas. Nesse sentido, inspirados na pedagogia queer, proposta de autoras como Deborah Britzman (1999) e Guacira Lopes Louro (2000), sugerimos uma Escola queerstionadora, na qual o currículo escolar adotaria estratégias em que estudantes seriam estimulados a questionar modelos hegemônicos e as supostas estruturas binárias de gênero e sexualidade, nos auxiliando a pensar um currículo vivo, dialógico e que potencialize as diferenças constitutivas do ser humano.
Palavras-chave: Educação. Diversidade sexual. Gênero. Currículo.
CURRÍCULO INTEGRADO NA MODALIDADE PROEJA NO INSTITUTO FEDERAL FARROUPILHA: Um olhar a partir dos docentes
Authors: Ernst Daniela Carolina , Soares Luciano Gonçalves , Nonenmacher Sandra Elizabet Bazana , Fontoura Ana Rita Kraemer da 
Published: August 2023

Apesar de diversas pesquisas educacionais apontarem a importância do Currículo Integrado (CI) para a formação de sujeitos omnilaterais, ainda existe descontinuidade entre o que se ensina e o que se pretende formar com o currículo integrado. Buscando caminhos para a superação dessas dualidades presentes na formação de Jovens e Adultos, estudantes de cursos PROEJA, desenvolveu-se essa pesquisa, realizada de maneira qualitativa com os professores de Ciências da Natureza, com o intuito de investigar possíveis caminhos para a implementação do Currículo Integrado em cursos de PROEJA, tentando identificar e entender seus processos formativos e de educação continuada, além de compreender e explicar os limites e reflexões desses professores e de seus processos dentro do CI. Os dados provenientes das análises dos documentos sobre CI Proeja foram categorizados seguindo o sistema de codificação proposto por Bogdan e Biklen (2006). Para isso, foram entrevistados 3 professores que trabalham com Ciências da Natureza no Instituto Federal Farroupilha na modalidade PROEJA: docentes de Química, Física e Biologia. Entendemos que o tempo-espaço da sala de aula constitui o âmago da implementação desse currículo e esse entendimento pode direcionar à percepção do conjunto de diferenças que dele fazem parte e assim contribuir para a sua efetiva aplicação.
Palavras-chave: Currículo Integrado. Proeja. Saberes Docentes.
Aplikasi Analytical Hierarchy Process (AHP) Metode Parwise Comparison Untuk Penentuan Kawasan Rawan Banjir di Balikpapan Tengah
Authors: Ryka Hamriani , Pratikno Fathony Akbar , Battu Desianto Payung 
Published: August 2023

Balikpapan City has recently often experienced flood natural disasters in certain locations, one of which is the Central Balikpapan District which results in losses, this study aims to analyze the flood-prone areas of Central Balikpapan. Analysis of flood-prone areas in this study used a Geographic Information System approach that was aligned with remote sensing. This analysis uses four parameters, namely (1) Slope Slope (2) Land Use (3) Distance to River (4) Rainfall. From the slope analysis of the slope of the study area located in the plain area (at a marble level of 0-13% to 21-55%). The land use analysis of the dominant research area is residential or built-up land. Analyze the distance to the river with <100-meters closest to the river. Daily rainfall analysis using the Ishoyet method resulted in a rainfall distribution of <13.6 mm which entered the low category. After processing the data of each parameter, a classification of each parameter was obtained in the form of a map, namely a rainfall map with a weight of 0.618448999, a map of the distance to the river with a weight of 0.144534112, a slope map with a weight of 0.122975261 and a land use map with a weight of 0.114041629. Obtained the flood vulnerability level of Central Balikpapan is the safest to occupy 8% of the research area, safely occupy 32% of the research area, threatened to occupy 45% of the research area and the last one is flood-prone by occupying 5% of the research area.Keywords: Flood, Geographic Information System (GIS), Analytic Hierarchy Processes (AHP), Balikpapan Tengah
Teaching English to Very Young Learners in Kindergartens in Myanmar
Authors: Po Ei Thet Hmoo , Pransiska Rismareni 
Published: August 2023

The purpose of this study is to determine the Implementation of Teaching English To Very Young Learners in kindergartens in Myanmar. The subjects of this study are the early childhood education teachers from Myanmar. The research problem is going to investigate is the practice of teaching in Myanmar particularly on the methods of teaching tend to implement in Yangon city Myanmar. Data is obtained through questionnaires. The Research findings on teachers’ involvement are first briefly reviewed, and then the analyses using the data are discussed to identify the trend and practice of teaching English in Kindergarten. It can be concluded that the planning, methods, the analysis used in this paper are in accordance with the references.
Introducción
Authors: Cuevas Vallejo Carlos Armando 
Published: August 2023

Los reportes de problemas en la enseñanza y aprendizaje del cálculo comparten mucho de la problemática de la enseñanza de la matemática en general y de las ciencias naturales. Problemas como:

Los cursos de matemáticas se encuentran desvinculados de las materas de especialidad que utilizan la matemática en escuelas de ingeniería y sociales.
Los cursos son ajenos a los intereses de los estudiantes y al entorno en donde viven.
Existe la bipolaridad de cursos meramente operativos, con empleo de fórmulas de forma memorística, descontextualizadas y carentes de significado. Y por la otra con un exceso de rigor y formalidad en donde los conceptos quedan ocultos.
Los profesores de matemáticas tienen muy poca comunicación con especialistas de otros cursos que componen la curricula escolar.
Existe poca disposición hacia el uso de softwares o tecnología digital de apoyo a los cursos.
Existe un alto grado de estudiantes que fallan en sus cursos lo cual conduce a un alto índice de reprobación y en consecuencia deserción.• La mayoría de los docentes carecen de una clara orientación didáctica que les permita estructurar sus cursos de acuerdo con la importancia de conceptos y necesidades.
Existe confusión al evaluar, dado que no se específica claramente el marco didáctico
Dado que se práctica una didáctica tradicional poco se hace para establecer una mejor conversión entre los registros de representación semiótica.
Effect of Healthcare Facilities on Climate Change: A Systematic Review of the Carbon Footprint of the Nigerian Healthcare Sector
Authors: Sumayya Al-Mansur , Adekunle Adeniji Abdur-Rahman , Olatunji Tijani Yusuf , Oluwatomisin Lawal Abdulwahab , Praise Ogunleke , Rolake Akin-Adewale , Rasheedat Shittu , Maryam Akande , Sanyolu Solagbade Remi 
Published: August 2023

Background: Climate change has continued to pose a global concern, as the resulting effect of the increase in greenhouse gas (GHG) emissions continues to have significant consequences on the planet and its inhabitants.
One of the major sectors contributing to the greenhouse effect is the healthcare sector, however, it is one of the sectors that has been overlooked and under reported.
Objective: This article aims at reviewing the carbon footprint of healthcare facilities in Nigeria and its impact on climate change, while highlighting important and effective strategies towards addressing it.
Methods: Data was obtained through a systematic review of available research articles obtained online via PubMed and Google scholar search engines, using the key words; climate change, healthcare facilities, global warming, and carbon footprint.
Results: Effective policy and regulatory frame works are essential towards addressing the carbon footprint of healthcare facilities; however a lot of gap still exists in curbing the effect of GHG emissions by healthcare facilities in Nigeria, as majority of healthcare facilities in Nigeria still rely significantly on the combustion of fossil fuels for generation of power due to its epileptic electrical power supply.
Conclusion: There is great need in addressing the effect of the carbon footprint of healthcare facilities on climate change. This can be achieved through the use of renewable energy technologies like solar and wind power, as well as the use of energy conservative measures such as the use of LED lighting and High-efficiency Heating, Ventilation, and Air Conditioning (HVAC) systems.
Computationally Guided Synthesis of MXenes by Dry Selective Extraction
Authors: Rems Ervin , Anayee Mark , Fajardo Eiara , Lord Robert L. , Bugallo David , Gogotsi Yury , Hu Yong‐Jie 
Published: August 2023

AbstractMXenes are a rapidly growing family of 2D transition metal carbides and nitrides that are promising for various applications, including energy storage and conversion, electronics, and healthcare. Hydrofluoric‐acid‐based etchants are typically used for large‐scale and high‐throughput synthesis of MXenes, which also leads to a mixture of surface terminations that impede MXene properties. Herein, a computational thermodynamic model with experimental validation is presented to explore the feasibility of fluorine‐free synthesis of MXenes with uniform surface terminations by dry selective extraction (DSE) from precursor MAX phases using iodine vapors. A range of MXenes and respective precursor compositions are systematically screened using first‐principles calculations to find candidates with high phase stability and low etching energy. A thermodynamic model based on the “CALculation of PHAse Diagrams” (CALPHAD) approach is further demonstrated, using Ti3C2I2 as an example, to assess the Gibbs free energy of the DSE reaction and the state of the byproducts as a function of temperature and pressure. Based on the assessment, the optimal synthesis temperature and vapor pressure are predicted and further verified by experiments. This work opens an avenue for scalable, fluorine‐free dry synthesis of MXenes with compositions and surface chemistries that are not accessible using wet chemical etching.
Iron‐Catalyzed Transfer Hydrogenation: Divergent Synthesis of Quinolines and Quinolones from ortho‐Nitrobenzyl Alcohols
Authors: Chun Simin , Reddy Putta Ramachandra , Hong Junhwa , Choi Seung Hyun , Oh Dong‐Chan , Hong Suckchang 
Published: August 2023

AbstractHerein, we report the divergent synthesis of quinolines and quinolones via a transfer hydrogenative condensation of ortho‐nitrobenzyl alcohols in one step. The reaction proceeded using the cyclopentadienone iron complex without any additional redox reagents. After transfer hydrogenation between ortho‐nitrobenzyl alcohols and secondary alcohols, the subsequent Friedländer annulation affords polysubstituted quinoline products in 22–90% (39 examples). The developed method was also applied to synthesize quinolones by using primary alcohols instead of secondary alcohols (12 examples). The obtained quinoline products were converted into several drug candidates to demonstrate its synthetic potential.
Development of Lysine Crotonyl‐Mimic Probe to Covalently Identify H3K27Cr Interacting Proteins
Authors: Guo Xiaochun , Wang Yuena , An Yuhao , Liu Zhihong , Liu Jianbo , Chen Jiaxin , Zhan Mei‐miao , Liang Mingcha , Hou Zhanfeng , Wan Chuan , Yin Feng , Wang Rui , Li Zigang 
Published: August 2023

AbstractHistone lysine crotonylation (Kcr) is one newly discovered acylation modification and regulates numerous pathophysiological processes. The binding affinity between Kcr and its interacting proteins is generally weak, which makes it difficult to effectively identify Kcr‐interacting partners. Changing the amide of crotonyl to an ester increased reactivity with proximal cysteines and retained specificity for Kcr antibody. The probe “H3g27Cr” was designed by incorporating the ester functionality into a H3K27 peptide. Using this probe, multiple Kcr‐interacting partners including STAT3 were successfully identified, and this has not been reported previously. Further experiments suggested that STAT3 possibly could form complexes with Histone deacetylase HDACs to downregulate the acetylation and crotonylation of Histone H3K27. Our unique design provided intriguing tools to further explore Kcr‐interacting proteins and elucidate their working mechanisms.
Laser induced fluorescence spectroscopy analysis of kidney tissues: A pilot study for the identification of renal cell carcinoma
Authors: Pavithran M Sanoop , Lukose Jijo , Barik Bijay Kumar , Periasami Ammasi , Kartha V. B. , Chawla Arun , Chidangil Santhosh 
Published: August 2023

AbstractThe 325 nm‐excited autofluorescence spectra from cancerous and normal renal tissues were collected ex vivo biopsy tissue samples, through an optical fiber probe‐based system. Noticeable changes in intensity/wavelength were observed in the fluorescence emissions from endogenous fluorophores such as collagen, Nicotinamide adenine dinucleotide (NADH), Vitamin A (retinol), and flavin adenine dinucleotide, in pathological conditions with respect to the normal state. The energy metabolism involved in clear cell renal cell carcinoma (ccRCC) and chromophobe renal cell carcinoma (chRCC) are reflected in the fluorescence emission band at 445 nm due to bound NADH attributed to enhanced oxidative phosphorylation in chRCC and emission at 465 nm contributed by free NADH showing higher glycolytic action in ccRCC. The principal component analysis and one‐way ANOVA effectively discriminate ccRCC from chRCC. It is shown that laser induced fluorescence technique with 325 nm excitation can be a suitable technique for optical pathology and in vivo surgical boundary demarcation in renal cell carcinoma.
Pharmacokinetics and Pharmacodynamics of GalNAc‐Conjugated siRNAs
Authors: An Guohua 
Published: August 2023

AbstractSmall interfering RNAs (siRNAs) represent a new class of drugs with tremendous potential for battling previously “undruggable” diseases. After nearly 2 decades of efforts in addressing the problems of the poor drug profile of naked unmodified siRNAs, this new modality has finally come to fruition, with 5 agents (patisiran, givosiran, lumasiran, inclisiran, and vutrisiran) being approved since 2018, and with many others in the different phases of clinical development. Unlike small‐molecule drugs and protein therapeutics, siRNAs have different sizes, distinct mechanisms of action, differing physicochemical and pharmacological properties, and, accordingly, a unique pharmacokinetic/pharmacodynamic (PK/PD) relationship. To support the continuous development of siRNAs, it is important to have a thorough and deep understanding of the PK/PD and clinical pharmacology related features of siRNAs. As most of the current siRNA products are conjugated by N‐acetylgalactosamine (GalNAc), this review focuses on the PK/PD relationships and clinical pharmacology of GalNAc‐conjugated siRNAs, including their absorption, distribution, metabolism, excretion (ADME) properties, PK/PD models, drug–drug interactions, clinical pharmacology in special populations, and safety evaluation. In addition, necessary background information related to the development of siRNAs as a therapeutic modality, including the mechanisms of action, the advantages of siRNAs, the problems of naked siRNAs, as well as the strategies used to enhance the clinical utility of siRNAs, have also been covered. The goal of this review is to serve as a “primer” on siRNA PK/PD, and I hope the readers, especially those who have a limited background on siRNA therapeutics, will have a fundamental understanding of siRNA PK/PD and clinical pharmacology after reading this review.