bluuebunny/crossref_metadata_2025_split huggingface dataset:
ADCY6 is a potential prognostic biomarker and suppresses OTSCC progression via Hippo signaling pathway
Authors: Yang Sen , Guo Li‐Juan , Liang Yong , He Zhi‐Ming , Luo Jia , Mu Yan‐Dong 
Published: August 2023

AbstractOral tongue squamous cell carcinoma (OTSCC) is a malignant tumor. Recently, studies have found that adenylate cyclase 6 (ADCY6) plays a pivotal role in many lethal tumors formation processes. The role of ADCY6 in OTSCC remains unknown. The expression of ADCY6 in OTSCC tissue samples was detected. The clinical significance of ADCY6 in OTSCC was analyzed by statistical methods. OTSCC cell lines were selected to analyze the biological function of ADCY6. Meanwhile, the effect of ADCY6 on the growth of OTSCC in vivo was explored using subcutaneous tumorigenesis assay. WB assay was used to detect the underlying signaling pathway. Cell function recovery test used to investigate the mechanism of ADCY6‐promoting OTSCC malignant biological behavior via Hippo signaling pathway. We report that ADCY6 was obviously downregulated in OTSCC tissue samples and cell lines. Importantly, lower expression of ADCY6 indicates a poorer prognosis in patients with OTSCC, and its expression is significantly correlated with TNM stage and tumor size. Functionally, forced expression of ADCY6 can significantly inhibit the proliferation, migration, invasion, and promote apoptosis of OTSCC cells. Mechanistically, we demonstrated that ADCY6 upregulation impaired Hippo signaling pathway to reduce the malignant biological behavior of OTSCC. Generally, our findings suggest that ADCY6 suppressed Hippo signaling pathway to regulate malignant biological behavior in OTSCC, which provide new cues for further exploring the mechanism of occurrence and development of OTSCC.
Systematic examination of post‐ and pre‐citation of Indian‐authored retracted papers
Authors: Palla Ishfaq Ahmad , Singson Mangkhollen , Thiyagarajan S. 
Published: August 2023

AbstractRetracted articles by Indian scholars have received significant attention in recent times. However, no comprehensive study has been conducted to analyse the citations of retracted papers authored by Indian researchers. This study aimed to assess the citations to retracted works published between 2001 and 2020 pre‐ and post‐retraction. The study found that there was an increase in retractions over time, with empirical data suggesting that the number of retractions has increased significantly, from 72 papers between 2001 and 2010 to 365 papers between 2011 and 2020. Duplication (n = 128) and plagiarism (n = 119) were the primary reasons for retraction. Notably, 90% of the retracted articles continued to receive citations after retraction. Among the retracted papers, eight received more than 50 post‐retraction citations, 39 received 20 to 50 citations, 347 received one to 19 citations, and 43 were not cited at all post‐retraction. There was an overall 8% decrease in citations after retraction. Retractions were observed across journals of varying impact factor, with a higher number of retractions observed in journals with an impact factor of less than 5 (n = 286; 65%). Furthermore, smaller research teams of two to five authors accounted for 72% of the total retractions.
The Mechanical and Biological Performance of Photopolymerized Gelatin‐Based Hydrogels as a Function of the Reaction Media
Authors: Pamplona Regina , González‐Lana Sandra , Romero Pilar , Ochoa Ignacio , Martín‐Rapún Rafael , Sánchez‐Somolinos Carlos 
Published: August 2023

AbstractFrom the first experiments with biomaterials to mimic tissue properties, the mechanical and biochemical characterization has evolved extensively. Several properties can be described, however, what should be essential is to conduct a proper and physiologically relevant characterization. Herein, the influence of the reaction media (RM) and swelling media (SM)–phosphate buffered saline (PBS) and Dulbecco's modified Eagle's medium (DMEM) with two different glucose concentrations–is described in gelatin methacrylamide (GelMA) hydrogel mechanics and in the biological behavior of two tumoral cell lines (Caco‐2 and HCT‐116). All scaffolds are UV‐photocrosslinked under identical conditions and evaluated for mass swelling ratio and stiffness. The results indicate that stiffness is highly susceptible to the RM, but not to the SM. Additionally, PBS‐prepared hydrogels exhibited a higher photopolymerization degree according to high resolution magic‐angle spinning (HR‐MAS) NMR. These findings correlate with the biological response of Caco‐2 and HCT‐116 cells seeded on the substrates, which demonstrated flatter morphologies on stiffer hydrogels. Overall, cell viability and proliferation are excellent for both cell lines, and Caco‐2 cells displayed a characteristic apical‐basal polarization based on F‐actin/Nuclei fluorescence images. These characterization experiments highlight the importance of conducting mechanical testing of biomaterials in the same medium as cell culture.
Bought but never used: How and when unused utility reduces subsequent spending
Authors: Koley Shruti , Reich Brandon 
Published: August 2023

AbstractConsumers often buy products that they later do not use. How does failing to use purchased products affect subsequent spending? Six experiments demonstrate that when consumers do not use their purchased products, it decreases their subsequent discretionary spending across product categories due to an aversion to wasted money. We find that this effect is driven primarily by perceived money waste and not product waste. Consequently, the effect persists even when consumers avoid product waste, such as by donating their unused products, but is mitigated when they avoid money waste, such as when their unused products are freely acquired. We also find that failing to use products decreases discretionary spending only when consumers perceive the failure as a temporary setback on their goal to avoid waste but not as an unredeemable goal failure. Moreover, the effect is unique to perceived waste and does not generalize to other forms of financial mismanagement, such as excess spending beyond one's budget. Overall, our research builds a psychological understanding of how consumers think about unused utility and when and why it leads to a future reduction in consumption and spending.
Preventing well leg compartment syndrome among patients in the lithotomy position—Operating room nurses' perspectives: A qualitative study
Authors: Susanne Johansson , Åsa Hörnsten 
Published: August 2023

AbstractAimTo describe operating room nurses' experiences of well leg compartment syndrome and how they work perioperative to prevent it during the lithotomy position.DesignThe study had a qualitative design.MethodsFocus group interviews were performed with 10 operating room (OR) nurses. The interviews were semi‐structured and analysed by qualitative content analysis. The study complied with the Consolidated Criteria for Reporting Qualitative Research (COREQ).ResultsThe main theme showed that the OR nurses shoulder duty and responsibility, independently and in the team, but they need more structural support and knowledge. The themes showed that they follow routines whenever possible and take responsibility for positioning; however, they have to balance between flexibility and strict routines. Although they also develop and participate in teamwork, they still need further knowledge.ConclusionThe severe complication of well leg compartment syndrome (WLCS) can occur when the patient is in the lithotomy position. Maintaining the same routines and paying attention to the WHO's surgical safety checklist were described as actions that could prevent well leg compartment syndrome.Patient or Public ContributionNo patient or public contribution. We have interviewed nurses but without financial support since the study was performed and supervised within a master programme.
Injection‐compression molding process on optical quality optimization of plastic lens array
Authors: Lin Chao‐Ming , Lin Yuan‐Qing 
Published: August 2023

AbstractPlastic lens arrays (PLAs) have the advantages of a light weight and a compact size. However, their optical performance is often degraded by warpage, caused by the accumulation of residual stress during the injection molding process. Accordingly, the present study employs mold flow analysis simulations and a Taguchi‐Gray relational analysis (GRA) framework to optimize the processing parameters of the injection compression molding (ICM) process. The analyses focus specifically on the effects of the mold temperature, melt temperature, injection velocity, packing pressure, packing time, and compression gap on the optical path difference (OPD) and lens center displacement (LCD) of the fabricated lens array. The results confirm that the optimized processing parameters significantly improve the OPD, LCD, birefringence, and imaging properties of the PLA compared to those of a PLA fabricated using standard molding conditions.
Prevalence of suspected autism spectrum disorder and attention‐deficit hyperactivity disorder in a Japanese clinical sample with gambling disorder: A cross‐sectional study
Authors: So Ryuhei , Sato Yoshitaka , Hashimoto Nozomu , Furukawa Toshi A. 
Published: August 2023

AbstractAimStudies show gambling disorders are associated with attention‐deficit hyperactivity disorder (ADHD). The association between gambling disorders and autism spectrum disorder (ASD) has not been well studied, although ASD is often comorbid with ADHD and is associated with gaming disorder. The aim of this study was to estimate the prevalence of ASD and ADHD traits comorbid with gambling disorders and to examine the relationships between these traits and gambling problems in a clinical population.MethodsThis single‐site cross‐sectional study was conducted at a Japanese addiction outpatient clinic treating gambling disorders. The Autism‐Spectrum Quotient (AQ) test and the Adult ADHD Self‐Report Scale (ASRS) were used to screen ASD and ADHD. The Problem Gambling Severity Index (PGSI) was used to assess the severity of the gambling problems. We calculated the prevalence of suspected ASD and ADHD with 95% confidence intervals (CI) based on a binomial distribution and performed univariate analyses to examine the relationships between the AQ and ASRS scores and the total PGSI score.ResultsWe included 97 of 197 potential participants. After screening the participants using the AQ and ASRS, we found that the prevalence of ASD traits was 29.8% (95% CI: 21.0%–40.2%), while the prevalence of ADHD traits was 26.0% (95% CI: 17.9%–36.2%). Univariate regression analyses revealed that the total AQ score was inversely associated with the total PGSI score. However, the total ASRS score and some ASRS subscores were positively associated with the total PGSI score.ConclusionASD and ADHD may be prevalent among patients with gambling disorders in clinical settings.
Flexural property characterization and structure analysis of graphene‐reinforced polyphenylene sulfide prepared via low‐cost pellet‐based material extrusion additive manufacturing
Authors: Wang Zhaogui , Xu Pengbo , Zhou Kexuan , Bi Chengping , Sun Ji'an 
Published: August 2023

AbstractThis paper proposed a low‐cost and high‐efficient method incorporating the graphene nanoplatelets (GNPs) into polyphenylene sulfide (PPS) as the feedstock of the pellet‐based material extrusion additive manufacturing (pMEAM). GNP/PPS particles with varying mass fractions are pre‐mixed by a mechanical mixer and then directly processed through a low‐cost screw‐based pMEAM system. The mechanical flexural properties of the samples are measured. The differential scanning calorimetry and thermogravimetric analysis are performed to explore the thermal‐related behavior of the samples. The optical microscopy and scanning electron microscopy are used for the characterization of the microstructures of the samples. The results indicate that the addition of GNP enhances the mechanical properties and thermal stability of PPS and GNP/PPS composites. Specifically, the flexural strength and modulus of the 0.05 wt.% GNP/PPS composite material increased by 21.7% and 17.5%, respectively. Nevertheless, an excessive amount of GNP can lead to decreased bending strength and other unstable mechanical properties. Microstructures of the prepared samples show that an increased fraction of graphene nanofillers reduces the hardness of the composites. Overall, the GNP/PPS prepared via our low‐cost pMEAM method exhibits a promising mechanical performance and can be further applied to large‐scale engineering applications for rapid productions.Highlights
A low‐cost and efficient method is employed to rapidly prototype GNP/PPS composites, employing a combination of pellet‐based material extrusion additive manufacturing and high‐speed mechanical mixing.
The mechanical and thermal properties of the GNP/PPS composites are notably improved by the addition of GNP fillers, resulting in increased flexural strength and stiffness, and higher material crystallinity.
Micro‐ and meso‐structural analysis reveals the uniform dispersion of graphene fillers in the interlayers, which potentially contributes to the improved mechanical properties, despite the presence of inherent micro‐voids.
Owing to the extensive functionalities of GNP, the proposed method offers a promising and viable alternative for the rapid fabrication of industrial parts and tooling on a large scale.
A review of three commonly used brief dyslexia rating scales
Authors: Storie Michelle S. , Joseph Laurice M. , Gillespie Theresa , McDougal James 
Published: August 2023

AbstractThe use of brief dyslexia rating scales is increasing given current dyslexia legislation efforts across the United States. The purpose of this article is to provide an overview of the historical context of the use of brief dyslexia rating scales, strengths, and limitations of using these measures, criteria for selecting these measures, and a review of three commonly used brief dyslexia rating scales in the United States. A discussion of how brief dyslexia rating scales can be used in conjunction with other forms of assessment is also provided. Implications for practice on using brief dyslexia rating scales are addressed in the context of both assessment and intervention.
Transcriptional analysis in multiple barley varieties identifies signatures of waterlogging response
Authors: Miricescu Alexandra , Brazel Ailbhe Jane , Beegan Joseph , Wellmer Frank , Graciet Emmanuelle 
Published: August 2023

AbstractWaterlogging leads to major crop losses globally, particularly for waterlogging‐sensitive crops such as barley. Waterlogging reduces oxygen availability and results in additional stresses, leading to the activation of hypoxia and stress response pathways that promote plant survival. Although certain barley varieties have been shown to be more tolerant to waterlogging than others and some tolerance‐related quantitative trait loci have been identified, the molecular mechanisms underlying this trait are mostly unknown. Transcriptomics approaches can provide very valuable information for our understanding of waterlogging tolerance. Here, we surveyed 21 barley varieties for the differential transcriptional activation of conserved hypoxia‐response genes under waterlogging and selected five varieties with different levels of induction of core hypoxia‐response genes. We further characterized their phenotypic response to waterlogging in terms of shoot and root traits. RNA sequencing to evaluate the genome‐wide transcriptional responses to waterlogging of these selected varieties led to the identification of a set of 98 waterlogging‐response genes common to the different datasets. Many of these genes are orthologs of the so‐called “core hypoxia response genes,” thus highlighting the conservation of plant responses to waterlogging. Hierarchical clustering analysis also identified groups of genes with intrinsic differential expression between varieties prior to waterlogging stress. These genes could constitute interesting candidates to study “predisposition” to waterlogging tolerance or sensitivity in barley.
The News Media Bargaining Code: Impacts on Australian journalism one year on
Authors: Bossio Diana , Barnet Belinda 
Published: August 2023

AbstractThe Australian News Media Bargaining Code (NMBC) is the first successful legislative attempt to compel digital platforms to pay news media organisations for third party news content. This paper focuses on the NMBC after its first year to explore whether the Code was successful in meeting one of its publicly stated purposes; supporting public interest journalism. We argue that the Code delivered outcomes that met the ACCC's policy objectives around an industry power imbalance, but there are several issues that remain unaddressed. Using semi‐structured interviews from Australian news media executives involved in negotiations with Meta and Google during the initial implementation of the Code, we explore: (a) how news organisations used financial compensation provided by agreements under the Code, (b) how individual organisational priorities were framed and articulated, and (c) whether these actions have supported public interest journalism in Australia. Our findings indicate that many of issues with the Code have emerged mostly from the unintended impacts of the Code, including: lack of designation of platforms within the legislation, the registration criteria for news outlets eligible to enter negotiation, and the definition of stakeholder relationships within the legislation.
Is digital intervention for fear of cancer recurrence beneficial to cancer patients?: A systematic review and meta‐analysis
Authors: Kang Namgu , Yu Eun‐Seung 
Published: August 2023

AbstractObjectiveThis study aimed to compare the effectiveness of digital and face‐to‐face interventions in reducing fear of cancer recurrence (FCR) among individuals with cancer.MethodsThis study was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) guidelines for evaluating the efficacy of psychological interventions for FCR published between July 2018 and December 2021. We searched for research papers using PubMed, Embase, and Cochrane and assessed their quality using the Revised Cochrane risk‐of‐bias tool for randomized trials.ResultsOf the 2113 identified studies, we analyzed 17 samples (N = 1482) from 14 studies, of which 13 were RCTs. The overall sample showed a moderate effect size (Hedges' g = 0.607; 0.356 to 0.858; p < 0.001; I2 = 81.29%) in FCR reduction. The overall effect size was 0.621 (95% CI, 0.276 to 0.966; p < 0.001; I2 = 81.78%) for face‐to‐face interventions and 0.517 (95% CI, 0.093 to 0.941; p = 0.017; I2 = 83.19%) for digital interventions. The difference between the two effect sizes was not statistically significant.ConclusionOur meta‐analysis suggests that digital interventions are moderately effective in reducing FCR, similar to face‐to‐face interventions. However, given the high degree of heterogeneity, this conclusion should be interpreted with caution. Further studies are required to identify the most effective digital interventions and the populations that may benefit from them.
Pathogenic mutation hotspots in protein kinase domain structure
Authors: Medvedev Kirill E. , Schaeffer R. Dustin , Pei Jimin , Grishin Nick V. 
Published: August 2023

AbstractControl of eukaryotic cellular function is heavily reliant on the phosphorylation of proteins at specific amino acid residues, such as serine, threonine, tyrosine, and histidine. Protein kinases that are responsible for this process comprise one of the largest families of evolutionarily related proteins. Dysregulation of protein kinase signaling pathways is a frequent cause of a large variety of human diseases including cancer, autoimmune, neurodegenerative, and cardiovascular disorders. In this study, we mapped all pathogenic mutations in 497 human protein kinase domains from the ClinVar database to the reference structure of Aurora kinase A (AURKA) and grouped them by the relevance to the disease type. Our study revealed that the majority of mutation hotspots associated with cancer are situated within the catalytic and activation loops of the kinase domain, whereas non‐cancer‐related hotspots tend to be located outside of these regions. Additionally, we identified a hotspot at residue R371 of the AURKA structure that has the highest number of exclusively non‐cancer‐related pathogenic mutations (21) and has not been previously discussed.
Evaporation of Dynamical Horizon with the Hawking Temperature in the K‐essence Emergent Vaidya Spacetime
Authors: Majumder Bivash , Ray Saibal , Manna Goutam 
Published: August 2023

AbstractIn the K‐essence Vaidya Schwarzschild spacetime, the dynamical horizon equation to measure the mass‐loss due to Hawking radiation and the tunneling formalism (Hamilton‐Jacobi method) to calculate the hawking temperature is applied. Assuming the Dirac‐Born‐Infeld kind of non‐standard action for the K‐essence here, the background physical spacetime is a static spherically symmetric black hole, and the K‐essence scalar field to be a function only of either forward or backward time is constrained. The K‐essence emergent gravity and the generalizations of Vaidya spacetime have been linked by Manna et al. In this paper, Sawayama's modified description of the dynamical horizon to show that the obtained findings deviate from the standard Vaidya spacetime geometry are used.
Effects of regional crop rotations on autumn insect pests in winter oilseed rape
Authors: Hausmann Johannes , Heimbach Udo , Gabriel Doreen , Brandes Meike 
Published: August 2023

AbstractBackgroundChemical control of insect pests in oilseed rape (OSR) is becoming increasingly difficult due to the development of resistance and restrictive insecticide approvals in Europe. At the same time, there is a lack of preventive and alternative control measures. Crop rotation mostly fails to control insects due to their mobility; however, changing regional cropping densities can dilute or concentrate pest pressure. In this study, we investigated whether the local occurrence of Psylliodes chrysocephala and Delia radicum, serious insect pests in winter OSR, is influenced by distance from the previous year's OSR fields and how changes in OSR rape cropping density at a regional scale (up to 10 km radius) affect pest pressure.ResultsAbundance of P. chrysocephala in yellow water traps decreased with increasing distance to previous year's OSR. Estimated catches in the first 3 weeks of migration were about 68–76% lower at 10 km distance compared to 1 km in autumn 2019 and 2020. However, in both seasons P. chrysocephala was able to disperse over distances of 10 km. Probability of root damage by D. radicum was affected by changes of OSR cropping area at a spatial scale of 2.5 km radius; it increased if acreage of OSR decreased. Furthermore, aphid infestation was lower when OSR was distant in the previous year.ConclusionThis study could enable field‐specific risk assessment and prediction of pest pressure. To decide about the effectiveness of cropping breaks at a regional level as a preventive crop protection measure, more knowledge on other pest species and antagonists is needed. © 2023 The Authors. Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.