bluuebunny/crossref_metadata_2025_split huggingface dataset:
JAKs and STATs from a Clinical Perspective: Loss-of-Function Mutations, Gain-of-Function Mutations, and Their Multidimensional Consequences
Authors: Ott Nils , Faletti Laura , Heeg Maximilian , Andreani Virginia , Grimbacher Bodo 
Published: May 2023

AbstractThe JAK/STAT signaling pathway plays a key role in cytokine signaling and is involved in development, immunity, and tumorigenesis for nearly any cell. At first glance, the JAK/STAT signaling pathway appears to be straightforward. However, on closer examination, the factors influencing the JAK/STAT signaling activity, such as cytokine diversity, receptor profile, overlapping JAK and STAT specificity among non-redundant functions of the JAK/STAT complexes, positive regulators (e.g., cooperating transcription factors), and negative regulators (e.g., SOCS, PIAS, PTP), demonstrate the complexity of the pathway’s architecture, which can be quickly disturbed by mutations. The JAK/STAT signaling pathway has been, and still is, subject of basic research and offers an enormous potential for the development of new methods of personalized medicine and thus the translation of basic molecular research into clinical practice beyond the use of JAK inhibitors. Gain-of-function and loss-of-function mutations in the three immunologically particularly relevant signal transducers STAT1, STAT3, and STAT6 as well as JAK1 and JAK3 present themselves through individual phenotypic clinical pictures. The established, traditional paradigm of loss-of-function mutations leading to immunodeficiency and gain-of-function mutation leading to autoimmunity breaks down and a more differentiated picture of disease patterns evolve. This review is intended to provide an overview of these specific syndromes from a clinical perspective and to summarize current findings on pathomechanism, symptoms, immunological features, and therapeutic options of STAT1, STAT3, STAT6, JAK1, and JAK3 loss-of-function and gain-of-function diseases.
‘It was Dangerous, Corrosive and Cruel but not Illegal’: Legal help-seeking Behaviours Amongst LGBTQA+ Domestic and Family Violence Victim-survivors Experiencing Coercive Control in Australia
Authors: Reeves Ellen , McGowan Jasmine , Scott Ben 
Published: May 2023

Abstract

Purpose
There is an expanding body of research interrogating lesbian, gay, bisexual, transgender, queer, asexual and other gender and sexuality diverse (LGBTQA+) persons’ experiences of domestic and family violence (DFV). However, few studies have considered LGBTQA+ persons’ specific experiences of ‘coercive control’ and none have considered legal help-seeking behaviours and decisions within this context. This article addresses this gap, through an examination of LGBTQA+ Australians’ experiences of legal help-seeking behaviours when experiencing coercive control from an intimate partner and/or family member.

Method
The article draws on the qualitative responses of a sample of 137 LGBTQA+ victim-survivors who participated in a survey on Australians’ experiences of coercive control. The analysis considers the reasons why some participants did not report abuse to the police, and the impact of police reporting for those who did.

Results
The study found that many of the concerns about the impact of reporting held by those who did not report to the police, were actualized in the experiences of those who did. Further, the study found that LGBTQA+ persons experience similar barriers to help-seeking compared to heterosexual and cisgender women, in addition to barriers that speak specifically to LGBTQA+ communities.

Conclusion
The findings of this study highlight the shortcomings of the law’s response to domestic and family violence and the need for intersectional responses to coercive control in Australia and beyond. The emerging findings presented in this article reinforce the importance and further need for research that specifically examines LGBTQA+ experiences of coercive control.
Improving Quantum Computation by Optimized Qubit Routing
Authors: Wagner Friedrich , Bärmann Andreas , Liers Frauke , Weissenbäck Markus 
Published: May 2023

AbstractIn this work we propose a high-quality decomposition approach for qubit routing by swap insertion. This optimization problem arises in the context of compiling quantum algorithms formulated in the circuit model of computation onto specific quantum hardware. Our approach decomposes the routing problem into an allocation subproblem and a set of token swapping problems. This allows us to tackle the allocation part and the token swapping part separately. Extracting the allocation part from the qubit routing model of Nannicini et al. (Optimal qubit assignment and routing via integer programming, 2021,http://arxiv.org/abs/2106.06446), we formulate the allocation subproblem as a binary linear program. Herein, we employ a cost function that is a lower bound on the overall routing problem objective. We strengthen the linear relaxation by novel valid inequalities. For the token swapping part we develop an exact branch-and-bound algorithm. In this context, we improve upon known lower bounds on the token swapping problem. Furthermore, we enhance an existing approximation algorithm which runs much faster than the exact approach and typically is able to determine solutions close to the optimum. We present numerical results for the fully integrated allocation and token swapping problem. Obtained solutions may not be globally optimal due to the decomposition and the usage of an approximation algorithm. However, the solutions are obtained fast and are typically close to optimal. In addition, there is a significant reduction in the number of artificial gates and output circuit depth when compared to various state-of-the-art heuristics. Reducing these figures is crucial for minimizing noise when running quantum algorithms on near-term hardware. As a consequence, using the novel decomposition approach leads to compiled algorithms with improved quality. Indeed, when compiled with the novel routing procedure and executed on real hardware, our experimental results for quantum approximate optimization algorithms show an significant increase in solution quality in comparison to standard routing methods.
Data based constitutive modelling of rate independent inelastic effects in composite cables using Preisach hysteresis operators
Authors: Manfredo Davide , Dörlich Vanessa , Linn Joachim , Arnold Martin 
Published: May 2023

AbstractThis contribution aims at introducing first steps to develop hysteresis operator type inelastic constitutive laws for Cosserat rods for the simulation of cables composed of complex interior components. Motivated by the basic elements of Cosserat rod theory, we develop a specific approach to constitutive modelling adapted for this application. Afterwards, we describe the hysteretical behaviour arising from cyclic bending experiments on cables by means of the Preisach operator. As shown in pure bending experiments, slender structures such as electric cables behave inelastically, and open hysteresis loops arise with noticeable difference between the first load cycle and the following ones. The Preisach operator plays an important role in describing the input-output relation in hysteresis behaviours, and it can be expressed as a superposition of relay operators. Hence, a mathematical formulation of the problem is introduced, and a first attempt is made to determine the hysteresis behaviour that describes the relation between curvature and bending moment. Therefore, a suitable kernel function is identified in a way that its integration over the Preisach plane results in the bending moment of the specimen, and a comparison between different kernel functions is performed.
Genome-wide profiling of patient-derived glioblastoma stem-like cells reveals recurrent genetic and transcriptomic signatures associated with brain tumors
Authors: Lazzarini Elisabetta , Silvestris Domenico Alessandro , Benvenuto Giuseppe , Osti Daniela , Fattore Luigi , Paterra Rosina , Finocchiaro Gaetano , Malatesta Paolo , Daga Antonio , Gallotti Alberto L. , Galli Rossella , Pelicci Giuliana , Tesei Anna , Bedeschi Martina , Pallini Roberto , Pasqualini Lorenza , Romualdi Chiara , Gallo Angela , Ricci-Vitiani Lucia , Indraccolo Stefano 
Published: May 2023

Abstract
Purpose
Patient-derived cancer cell lines can be very useful to investigate genetic as well as epigenetic mechanisms of transformation and to test new drugs. In this multi-centric study, we performed genomic and transcriptomic characterization of a large set of patient-derived glioblastoma (GBM) stem-like cells (GSCs).

Methods
94 (80 I surgery/14 II surgery) and 53 (42 I surgery/11 II surgery) GSCs lines underwent whole exome and trascriptome analysis, respectively.

Results
Exome sequencing revealed TP53 as the main mutated gene (41/94 samples, 44%), followed by PTEN (33/94, 35%), RB1 (16/94, 17%) and NF1 (15/94, 16%), among other genes associated to brain tumors. One GSC sample bearing a BRAF p.V600E mutation showed sensitivity in vitro to a BRAF inhibitor. Gene Ontology and Reactome analysis uncovered several biological processes mostly associated to gliogenesis and glial cell differentiation, S − adenosylmethionine metabolic process, mismatch repair and methylation. Comparison of I and II surgery samples disclosed a similar distribution of mutated genes, with an overrepresentation of mutations in mismatch repair, cell cycle, p53 and methylation pathways in I surgery samples, and of mutations in receptor tyrosine kinase and MAPK signaling pathways in II surgery samples. Unsupervised hierarchical clustering of RNA-seq data produced 3 clusters characterized by distinctive sets of up-regulated genes and signaling pathways.

Conclusion
The availability of a large set of fully molecularly characterized GCSs represents a valuable public resource to support the advancement of precision oncology for the treatment of GBM.
Meta-uncertainty and the proof paradoxes
Authors: Steele Katie , Colyvan Mark 
Published: May 2023

AbstractVarious real and imagined criminal law cases rest on “naked statistical evidence”. That is, they rest more or less entirely on a probability for guilt/liability derived from a single statistical model. The intuition is that there is something missing in these cases, high as the probability for guilt/liability may be, such that the relevant standard for legal proof is not met. Here we contribute to the considerable debate about how this intuition is best explained and what it teaches us about evidential reasoning in the legal setting. We part ways with the recent scholarship, however. Unlike most others, our diagnosis is not that there is an important qualitative property that some evidence or bodies of evidence have, and that naked statistical evidence, most strikingly, lacks. Rather, we see cases resting on naked statistical evidence as lying at the extreme of a continuum of cases that are vulnerable to challenge due to “meta-uncertainty” about the underlying model.
How risky is distracted driving?
Authors: Karl J. Bradley , Nyce Charles M. , Powell Lawrence , Zhuang Boyi 
Published: May 2023

AbstractWe use data on fatal crashes to quantify the risk of distracted driving. We repurpose, extend, and improve a methodology used to estimate the riskiness of drinking drivers (Levitt & Porter, 2001). Our analysis suggests that distracted drivers are three times more likely to cause a fatal crash than focused drivers. We also estimate that distracted drivers represent three to four percent of drivers on the road at any given time. Further, we find that distractions associated with cellphone use are less likely to cause a fatal crash than are distractions from other sources. The externality costs between $0.02 and $0.05 per mile driven. The insurance surcharge for a distracted driving citation that could internalize the avoidable insurance losses is approximately $577 per year. Our work extends the literature on distracted driving and traffic fatalities. We believe our results can inform policymakers on the traffic-safety and economic consequences of distracted driving.
Effect of exogenus protease on performance, nutrient digestibility, intestinal histomorphometric, meat quality characteristics, carcass yield in broilers fed low protein diets
Authors: Duque-Ramírez C. F. , Javierre J. A. , Peñuela-Sierra L. M. , Diaz-Vargas M. 
Published: May 2023

Abstract
The objective of the present study was to evaluate the effects of increasing doses of protease on broilers from 1 to 42 days of age. A total of 1290 Ross AP broilers were used, distributed among five treatments: positive control diet, negative control diet (NC), NC + 50 ppm of protease, NC + 100 ppm of protease, and NC + 200 ppm of protease. Each treatment contained six replicates of 43 animals each. The inclusion of proteases in the diet had effects (P < 0.05) on body weight, feed intake, weight gain, and feed conversion in the 12 to 21 day period; body weight, weight gain, and feed intake in the 29 to 42 day period; nutrient digestibility (energy metabolizability coefficient and crude protein at 28 days); and intestinal parameters (crypt and muscle width of jejunum and ileum at 28 days and villus length, crypt length, and jejunum thickness muscle layer at 42 days). These results indicate that the inclusion of protease in broiler feed can improve production parameters when the amount of crude protein in the diet is reduced.
The Mediating Role of Migrant Community-Based Organizations: Challenges and Coping Strategies
Authors: Martinez-Damia Sara , Marzana Daniela , Paloma Virginia , Marta Elena 
Published: May 2023

AbstractMigrant community-based organizations (MCBOs) are key mediating structures between immigrants and host societies. However, when implementing this role in host societies, MCBOs often face a number of challenges that reduce their chances to be effective in promoting social justice. This paper aims to analyze the challenges that MCBOs settled in Milan (Northern Italy) experience and the coping strategies that they use in order to provide some guidelines on how to support them. In-depth interviews, observations and document analysis with 15 MCBOs were conducted. Based on a situational analysis, we present the main challenges perceived by MCBOs at three levels: internal (i.e., surviving), inter-organizational (i.e., collaborating) and community (i.e., being recognized as mediating actors). We provide specific guidelines for action on how to address such challenges and thus foster the role of MCBOs as mediating structures in receiving societies.
Cyanobacteria as a Valuable Natural Resource for Improved Agriculture, Environment, and Plant Protection
Authors: Abo-Shady Atef M. , Osman Mohamed El-Anwar H. , Gaafar Reda M. , Ismail Gehan A. , El-Nagar Maysa M. F. 
Published: May 2023

AbstractTaking into consideration, the challenges faced by the environment and agro-ecosystem make increased for suggestions more reliable methods to help increase food security and deal with difficult environmental problems. Environmental factors play a critical role in the growth, development, and productivity of crop plants. Unfavorable changes in these factors, such as abiotic stresses, can result in plant growth deficiencies, yield reductions, long-lasting damage, and even death of the plants. In reflection of this, cyanobacteria are now considered important microorganisms that can improve the fertility of soils and the productivity of crop plants due to their different features like photosynthesis, great biomass yield, ability to fix the atmospheric N2,capability to grow on non-arable lands, and varied water sources. Furthermore, numerous cyanobacteria consist of biologically active substances like pigments, amino acids, polysaccharides, phytohormones, and vitamins that support plant growth enhancement. Many studies have exposed the probable role of these compounds in the alleviation of abiotic stress in crop plants and have concluded with evidence of physiological, biochemical, and molecular mechanisms that confirm that cyanobacteria can decrease the stress and induce plant growth. This review discussed the promising effects of cyanobacteria and their possible mode of action to control the growth and development of crop plants as an effective method to overcome different stresses.Graphical Abstract
Factors Influencing Primary Care Practitioners’ Cancer Screening Recommendations for Older Adults: a Systematic Review
Authors: Smith Jenna , Dodd Rachael H. , Gainey Karen M. , Naganathan Vasi , Cvejic Erin , Jansen Jesse , McCaffery Kirsten J. 
Published: May 2023

Background
Primary care practitioners (PCPs) play a key role in cancer screening decisions for older adults (≥ 65 years), but recommendations vary by cancer type and jurisdiction.

Purpose
To examine the factors influencing PCPs’ recommendations for breast, cervical, prostate, and colorectal cancer screening for older adults.

Data Sources
MEDLINE, Pre-Medline, EMBASE, PsycINFO, and CINAHL, searched from 1 January 2000 to July 2021, and citation searching in July 2022.

Study Selection
Assessed factors influencing PCPs’ breast, prostate, colorectal, or cervical cancer screening decisions for older adults’ (defined either as ≥ 65 years or < 10-year life expectancy).

Data Extraction
Two authors independently conducted data extraction and quality appraisal. Decisions were crosschecked and discussed where necessary.

Data Synthesis
From 1926 records, 30 studies met inclusion criteria. Twenty were quantitative, nine were qualitative, and one used a mixed method design. Twenty-nine were conducted in the USA, and one in the UK. Factors were synthesized into six categories: patient demographic characteristics, patient health characteristics, patient and clinician psycho-social factors, clinician characteristics, and health system factors. Patient preference was most reported as influential across both quantitative and qualitative studies. Age, health status, and life expectancy were also commonly influential, but PCPs held nuanced views about life expectancy. Weighing benefits/harms was also commonly reported with variation across cancer screening types. Other factors included patient screening history, clinician attitudes/personal experiences, patient/provider relationship, guidelines, reminders, and time.

Limitations
We could not conduct a meta-analysis due to variability in study designs and measurement. The vast majority of included studies were conducted in the USA.

Conclusions
Although PCPs play a role in individualizing cancer screening for older adults, multi-level interventions are needed to improve these decisions. Decision support should continue to be developed and implemented to support informed choice for older adults and assist PCPs to consistently provide evidence-based recommendations.

Registration
PROSPERO CRD42021268219.

Funding Source
NHMRC APP1113532.
Peri- and Postoperative Outcomes for Obstructive Sleep Apnoea Patients after Bariatric Surgery—a Systematic Review and Meta-analysis
Authors: Katasani Tarun , Holt Guy , Al-Khyatt Waleed , Idris Iskandar 
Published: May 2023

Abstract
Background
Obstructive sleep apnoea (OSA) is prevalent among patients undergoing bariatric surgery. Previous studies have reported a higher risk of complications, ICU admission and longer length of stay in patients with OSA following surgery. However, clinical outcomes following bariatric surgery are unclear. The hypothesis is that patients with OSA will have an increased risk of these outcome measures after bariatric surgery.

Methods
A systematic review and meta-analysis were performed to answer the research question. Searches for bariatric surgery and obstructive sleep apnoea were performed using PubMed and Ovid Medline. Studies which compared OSA and non-OSA patients undergoing bariatric surgery and used outcome measures that included length of stay, risk of complications, 30-day readmission and need for ICU admission were selected for the systematic review. Comparable datasets from these studies were used for the meta-analysis.

Results
Patients with OSA are at greater risk of complications after bariatric surgery (RR = 1.23 [CI: 1.01, 1.5], P = 0.04), driven mostly by an increased risk of cardiac complications (RR = 2.44 [CI: 1.26, 4.76], P = 0.009). There were no significant differences between the OSA and non-OSA cohorts in the other outcome variables (respiratory complications, length of stay, 30-day readmission and need for ICU admission).

Conclusion
Following bariatric surgery, patients with OSA must be managed carefully due to the increased risk of cardiac complications. However, patients with OSA are not more likely to require a longer length of stay or readmission.

Graphical Abstract
Effect of Different Listening Behaviors of Social Robots on Perceived Trust in Human-robot Interactions
Authors: Anzabi Naeimeh , Umemuro Hiroyuki 
Published: May 2023

AbstractWith the increased use of social robots in prominence and beyond functional performance, they are expected to foster trust and confidence in people. Various factors involve providing social robots with more trustworthy behavior. This study investigated whether the listening behavior of a social robot can affect the perception of being trustworthy in human–robot interaction. Therefore, we designed four different listening behaviors, including nonactive listening, active listening, active empathic listening, and verbal-only empathic listening, for a social robot and evaluated the impact of each behavior on the participants’ likelihood of trusting the robot, using a between-subject design. Participants in the four conditions conversed with a robot that simulated one of the listening behaviors, and their general, cognitive and affective trust toward the robot was measured. The results indicated that active empathic listening behavior provided the participants with the highest impression of trustworthiness, specifically in affective trust. Both active listening and active empathic listening were evaluated higher than nonactive listening in general, affective, and cognitive trust. However, active empathic listening behavior was differentiated from active listening behavior only in terms of affective trust. For verbal and nonverbal dimensions of listening behaviors, it was confirmed that nonverbal behaviors such as nodding, body movement, and eye gaze along with verbal behaviors, had a significant effect in eliciting higher affective trust in human-robot interaction. Consequently, we concluded that designing social robots with active (empathic) listening behavior can enhance trust perception in human-robot interaction in different fields such as education, healthcare, and business.