bluuebunny/crossref_metadata_2025_split huggingface dataset:
CircRNA Circ_0000118 Regulates Malignancy of Cervical Cancer Cells by Regulating miR-211-5p/miR-377-3p/AKT2 Axis
Authors: Wu Lilan , Xiao Huiqin , Hong Yaqin , Xie Meihua , Yu Yanxia , Jiang Lijuan 
Published: January 2023

AbstractCircRNAs are implicated in the development of several cancers. Nevertheless, the involvement of circ_0000118 in the development of cervical cancer (CC) remains unclear. Circ_0000118 levels in tumor tissues and cells were examined by qRT-PCR. The function of circ_0000118 in regulating the malignancy of CC cells was investigated using functional assays, including CCK-8, colony formation, transwell, and tube formation experiments. The functional interaction between circ_0000118 and microRNAs were validated by dual-luciferase activity assay and RNA precipitation experiments. In vivo mouse model was employed to assess the effect of circ_0000118 in the tumorigenesis of CC cells. Circ_0000118 was overexpressed in CC cells and tissues. Loss-of-function experiments demonstrated that circ_0000118 knockdown impaired the proliferation and tumor sphere formation, as well as the angiogenic potential of CC cells. RNA interaction experiments confirmed that circ_0000118 sponged miR-211-5p and miR-377-3p. AKT2 was found to be a target gene negatively modulated by miR-211-5p and miR-377-3p. AKT2 overexpression rescued the inhibition of circ_0000118 downregulation on CC cells. Our study suggested that circ_0000118 functions as an oncogenic factor in progression of CC by maintaining AKT2 level through targeting miR-211-5p and miR-377-3p as a ceRNA (competitive endogenous RNA), which provides novel therapeutic target in the management of CC.
Corporate Responses to Community Grievance: Voluntarism and Pathologies of Practice
Authors: Owen John R. , Kemp Deanna 
Published: January 2023

AbstractGrievance landscapes form in rapidly industrialising contexts where social and environmental impacts are inevitable. This paper focuses on the complex operational and organisational settings in which grievances arise and the industrial pathologies that form around resource development projects. The arguments draw on classic and contemporary literature on “grievance”, “right” and “entitlement”, and the authors’ own sustained engagement with global mining companies and local communities. Our contention is that the grievance landscape is far more critical to understanding environmental, human rights, and mining interactions than the managerial systems that companies construct to signal compliance with voluntary international norms. These managerial systems, or operational-level grievance mechanisms, map the procedural contours of how a local grievance would travel once it is made visible to the company. In practice, however, it is fiction, illegibility and invisibility that dominate. Across the pathologies, the common denominator is the corporate propensity to avoid recognising the legitimacy of a local grievance and the source of its cause.
Odors Attracting the Long-Legged Predator Medetera signaticornis Loew to Ips typographus L. Infested Norway Spruce Trees
Authors: Sousa Maria , Birgersson Göran , Karlsson Green Kristina , Pollet Marc , Becher Paul G. 
Published: January 2023

Abstract
Predatory long-legged flies of the genus Medetera are important, but currently understudied, natural enemies of Scolytinae bark beetles such as Ips typographus. Medetera flies lay eggs on beetle-infested trees, where the developing larvae find their prey, but the chemical cues used by Medetera to locate infested trees are currently unknown. To identify odors attracting Medetera signaticornis, a species in Europe, headspace samples were collected at several time-points through different stages of I. typographus attacks on logs of Norway spruce (Picea abies). The headspace samples were analyzed using combined gas chromatography and mass spectrometry (GC–MS), and gas chromatography coupled with electroantennographic detection (GC-EAD) to determine compounds that stimulate M. signaticornis antennae. Antennae of M. signaticornis males and females were found to detect (–)-cis-verbenol, ( +)-trans-verbenol and myrtenol, which are known to be produced by bark beetles. Antennal responses were also observed for verbenene, isoterpinolene, α-pinene oxide, camphor, pinocamphone, terpinene-4-ol, myrtenal, borneol, α-terpineol, geranyl acetone, and verbenone, which are primarily produced by microorganisms, and α-pinene, α-fenchene, β-pinene, camphene, 3-carene, limonene, γ-terpinene, and terpinolene, known spruce tree compounds. In field experiments testing two synthetic blends containing 18 antennal active and two additional compounds 2-methyl-3-buten-2-ol and ipsdienol we observed significant attraction of M. signaticornis within 24 h. These attractive blends can form the basis for development of Medetera monitoring lures for use in future forest and pest management.
Prenatal Mental Representations in Italian First-Time Mothers Before and During the COVID-19 Pandemic: A Study with Interviews on Maternal Representations During Pregnancy
Authors: Smorti Martina , Mauri Giulia , Carducci Alessia , Andreol Angelica , Bonassi Lucia 
Published: January 2023

Abstract
Introduction
Psychosocial risks increase the levels of not-integrated/ambivalent and restricted/disengaged representations during pregnancy, but no study has specifically analysed the impact of the COVID-19 pandemic on maternal representation styles.

Objectives
(1) to compare maternal representation styles in primiparous women who became pregnant before and during the COVID-19 pandemic and (2) to analyse the content of representation styles during the COVID-19 pandemic.

Methods
A total of 37 Italian pregnant women were recruited from 2019 to 2021. The sample was divided into two groups: the pre-COVID-19 group (22 women, mean age = 33.14 years; SD = 3.78) and the COVID-19 group (15 women, mean age = 35.9 years; SD = 4.6). Interviews on maternal representations during pregnancy were administered and analysed for style and content. Results: Women during the COVID-19 pandemic reported more restricted/disengaged and less integrated/balanced representation styles than women pre-COVID-19. Content analysis showed that the COVID-19 pandemic led women to focus more on concrete aspects of pregnancy in lieu of emotional aspects, thus leading them to develop more restricted/disengaged representation styles.

Conclusions for practice
In future pandemics pregnant women should be supported in focusing their attention to emotions, sensations and fantasies about themselves as mothers and their children.
Lansoprazole attenuates cyclophosphamide-induced cardiopulmonary injury by modulating redox-sensitive pathways and inflammation
Authors: Hassanein Emad H. M. , Kamel Esam O. , Gad-Elrab Wail M. , Ahmed Mohammed A. , Mohammedsaleh Zuhair M. , Ali Fares E. M. 
Published: January 2023

AbstractCyclophosphamide (CPA) is a classical chemotherapeutic drug widely used as an anticancer and immunosuppressive agent. However, it is frequently associated with significant toxicities to the normal cells of different organs, including the lung and heart. Lansoprazole (LPZ), a proton pump inhibitor (PPI), possesses antioxidant and anti-inflammatory properties. The current study investigated how LPZ protects against CPA-induced cardiac and pulmonary damage, focusing on PPARγ, Nrf2, HO-1, cytoglobin, PI3K/AKT, and NF-κB signaling. Animals were randomly assigned into four groups: normal control group (received vehicle), LPZ only group (Rats received LPZ at a dose of 50 mg/kg/day P.O. for 10 days), CPA group (CPA was administered (200 mg/kg) as a single i.p. injection on the 7th day), and cotreatment group (LPZ plus CPA). Histopathological and biochemical analyses were conducted. Our results revealed that LPZ treatment revoked CPA-induced heart and lung histopathological alterations. Also, LPZ potently mitigated CPA-induced cardiac and pulmonary oxidative stress through the activation of PPARγ, Nrf2/HO-1, cytoglobin, and PI3K/AKT signaling pathways. Also, LPZ effectively suppressed inflammatory response as evidenced by down-regulating the inflammatory strategic controller NF-κB, MPO, and pro-inflammatory cytokines. The present findings could provide a mechanistic basis for understanding LPZ's role in CPA-induced cardiopulmonary injury through the alleviation of oxidative stress and inflammatory burden.
Implementation frameworks for polypharmacy management within healthcare organisations: a scoping review
Authors: Al Bulushi S. , McIntosh T. , Grant A. , Stewart D. , Cunningham S. 
Published: January 2023

Abstract
Background
Several guidelines support polypharmacy management in individual patients. More organisational-level focus is needed on the use of implementation frameworks.

Aim
To characterise the peer reviewed literature on implementation frameworks, focussing on barriers and facilitators to implementation at organisational level in the context of polypharmacy management.

Method
A scoping review protocol was devised, supporting retrieval of studies published in English, reporting from any sector of practice. Medline, International Pharmaceutical Abstracts, Cumulative Index of Nursing and Allied Health Literature and Business Source Complete were searched to January 2022 using Medical Subject Headings including: ‘polypharmacy’, ‘deprescriptions’, ‘strategic planning’ and ‘organizational innovation’. A narrative approach to data synthesis was applied. Searching, data extraction and synthesis were undertaken independently by two reviewers.

Results
After screening 797 records eight papers remained. Two were descriptive outlining details of specific initiatives, six used qualitative methods to explore determinants for implementation including barriers and enablers. Organisation level barriers included: poor organisational culture with a lack of sense of urgency and national plans, resource availability and communication issues including patient information and at transitions of care. Organisational facilitators included availability of government funding and regulatory environment promoting patient safety, a national emphasis on quality of care for older adults, co-ordinated national efforts and local evidence.

Conclusion
Limited literature focusses on the use of implementation frameworks at organisational levels. This review highlights the need for further work on implementation frameworks in this context to help achieve effective organisational change.
Climatic and Other Global Changes as Current Challenges in Improving Water Systems Management: Lessons from the Case of Italy
Authors: Rossi Giuseppe , Peres David J. 
Published: January 2023

AbstractClimate change linked to human activities is affecting natural systems, increasing frequency and severity of water-related hazards. The issue of climate change pushes to tackle the expected risks in the water sector through a comprehensive and global view, with a revision of the paradigms considered as drivers of water resources development. Based on the evolution of these paradigms in Italy the main characteristics of an adaptive approach to climate change and other global changes are discussed relatively to water infrastructures, legislative and institutional frameworks. The objective of adaptation strategies is the increase of resilience of water systems, emphasizing the capability of reducing both physical and socio-political vulnerability, improving the governance of water services. Starting from the analysis of the evolution of water management, priorities for coping with future challenges are discussed with reference to the reduction of the risk of water shortage due to drought, to the mitigation of flood risk, and to the issues concerning the water-food-energy nexus.
Religionsoffen und zuschreibungsreflexiv
Authors: Seiler Elke 
Published: January 2023

ZusammenfassungDer Artikel rückt die Bedeutung des gesellschaftlichen Diskurses um Religion und religiöse Zugehörigkeit in den Mittelpunkt des pädagogischen Interesses. Weniger als um Verständnis differenter Glaubensfragen sollten Pädagog_innen um die Wahrnehmung und Reflexion von Zuschreibungen von Zugehörigkeit und Nichtzugehörigkeit bemüht sein. Zudem wird die Frage aufgeworfen, wie angesichts einer verbreiteten Diskriminierungsrealität eine Anerkennung (auch) religiöser Ausdrucksformen gelingen kann.
Barriers to patient access of CAR T cell therapies in Austria
Authors: Hopfinger Georg , Rupp Bernhard , Greil Richard 
Published: January 2023

SummaryChimeric antigen receptor (CAR) T cell therapies offer a promising new therapeutic option for treating B cell malignancies, for instance relapsed or refractory diffuse large B cell lymphoma (DLBCL). However, patient access to this type of cellular immunotherapy may be limited due to systemic barriers even in wealthy Western countries. In Austria, the CAR T eligible DLBCL population is estimated to encompass approximately 56 patients based on the criteria applied for CAR T registrational trials. However, less than 40% of these DLBCL patients eligible for commercial standard-of-care CAR T cell therapy were finally treated with CAR T cell therapy in 2021 based on our analysis. This report discusses potential barriers that may impede current patient access to CAR T cell therapy and provides recommendations for systemic solutions to address these barriers and improve the CAR T access situation in Austria.
Exposure Factors vs. Bioaccessibility in the Soil-and-Dust Ingestion Pathway: A Comparative Assessment of Uncertainties Using MC2D Simulations in an Arsenic Exposure Scenario
Authors: Barrio-Parra F. , Serrano García H. , Izquierdo-Díaz M. , De Miguel E. 
Published: January 2023

AbstractHuman Health Risk Assessment (HHRA) is a widely applied method to make decisions about the environmental status of sites affected by toxic substances. Its conclusions are affected by the variability and uncertainty of the input variables in the HHRA model. The aim of this work is to apply an algorithm based on 2D Monte Carlo simulations to integrate the variability and uncertainty of exposure factors, concentration, and bioaccessibility, reported by various information sources, to assess and compare their influence on the risk outcome. The method is applied to a specific case study of exposure of children to arsenic from accidental soil ingestion in a residential setting in the city of Madrid (Spain) by combining information from 12 studies. The consideration of the variability and uncertainty of the exposure parameters in the Baseline Risk Assessment (BRA, deterministic) resulted in a greater reduction in the numerical value of risk estimations than that produced by considering only the bioaccessibility factor. The results of the Probabilistic Risk Assessment (PRA) showed that the risk distribution was more sensitive to the variabilities of the accidental soil intake rate and the total arsenic concentration than to other variables such as bioaccessibility. In this case study, the uncertainty introduced by using the "default" reasonable maximum exposure factors in the HHRA model and the variability of the concentration term produce overestimates of risk that are at least in the range of those produced by omitting the bioaccessibility term. Thus, the inclusion of bioaccessibility is, alone, insufficient to improve the HHRA since the selection of the exposure factors can significantly affect the estimates of risk for the soil ingestion pathway. In other sites or for other contaminants, however, the role of the uncertainties associated with the bioaccesible fraction could be more pronounced. The method applied in this work may be useful in updating exposure factors to reduce uncertainties in HHRAs.
Bio-utilization of agricultural residue banana plant shoot through solid state fermentation for production of inulinase using newly isolated Nothophoma anigozanthi JAM
Authors: Tippanavar Nisarga , Bhat Divya , Rebello Orline , Prabhu Girisa , Selvaraj Subbalaxmi , Bhat Ramananda M. 
Published: January 2023

AbstractThe present research was carried out with the objectives of isolating fungal strains capable of exhibiting inulinase activity from a novel source, then optimizing solid state fermentation for the inulinase production and characterizing crude enzyme. Production of inulinase is first reported in this study with a novel substrate, banana plant shoot powder, using newly isolated fungal strain Nothophoma anigozanthi JAM through solid state fermentation. The fungal strain was isolated from the root soil of a white Jamun (Syzygium cumini) tree. Optimization of the solid state fermentation was carried out by central composite design for determining the interaction and impact of the influential process on inulinase production. A mathematical model was developed based on the statistical analysis and recommended optimal process conditions of 2 g of substrate, 5 mL of moistening media, 5 mL of inoculum volume, and 96 h of fermentation time for enhanced production (2.578 U/gds). Crude inulinase enzyme exhibited an 8.0-fold increase in activity after optimization, in comparison with the activity under unoptimized conditions. The optimum pH (5.0), temperature (60 °C) for the enzyme activity, and Km (0.205 mM) and Vmax (0.333 µM/min) were determined based on the biochemical and inulin hydrolytic properties of the crude inulinase enzyme. The production of inulinase was further validated by using TLC, osazone, and Seliwanoff tests. Hence, the inulinase enzyme produced by Nothophoma anigozanthi JAM can be successfully utilized for the production of edible sugar fructose from non-edible polysaccharide inulin, present in agricultural residues such as banana shoot by solid state fermentation.
Muscle fat infiltration in chronic kidney disease: a marker related to muscle quality, muscle strength and sarcopenia
Authors: Avesani Carla Maria , de Abreu Aline Miroski , Ribeiro Heitor S. , Brismar Torkel B. , Stenvinkel Peter , Sabatino Alice , Lindholm Bengt 
Published: January 2023

AbstractMuscle fat infiltration (MFI) also known as myosteatosis refers to any deposit of lipids found in the skeletal muscle. MFI is preferably assessed by image-based methods like computed tomography (CT), magnetic resonance image (MRI) and ultrasound, normally from muscle groups located in the legs, arms and in the trunk. MFI is understood as a marker of muscle quality, where a muscle with higher fat deposition has lower contraction power and capacity to produce force per unit of muscle mass. This concept supports the hypothesis that a decrease in muscle strength is not always explained by a decrease in muscle mass, but also by other factors, including lipid deposition in the muscle. In the general population, MFI is associated with older age, physical inactivity and with insulin resistance and inflammation. In chronic kidney disease (CKD), MFI has been associated with a decrease in muscle strength and impaired muscle quality as well as with metabolic abnormalities, cardiovascular disease and increased mortality. Interventions aimed at reducing MFI in CKD are incipient, but it seems that guided exercise can ameliorate muscle quality in patients on hemodialysis. The aim of this narrative review about MFI in CKD is to draw attention to a still not often addressed complication in CKD. We conclude that more studies are warranted to investigate mechanisms and factors promoting MFI in CKD. Thus, clinical trials aimed at understanding the type, frequency and intensity of exercise that can diminish MFI and improve the clinical condition of the patients are needed.Graphical Abstract
The Teaching of Collaborative Creativity, a Methodological Approach to Designing the Environment
Authors: Peralta Hernández Jesús , Tirado Segura Felipe 
Published: January 2023

AbstractThe emerging problems are characterized by their high level of complexity. Faced with this scenario, the teacher must propose methodologies that promote collaborative creativity in search of solutions to emerging problems. Designing environments that promote it represents an alternative for this purpose. We conducted this research in a university course that taught collaborative creativity to solve emerging professional problems. It used a methodological approach based on the analysis and adjustments to the educational environment. For this, an Educational Design Research was carried out to improve the environment by identifying and solving its contradictions. We obtained creativity indicators to evaluate the effects of the transformations made to the environment. The overall results showed an increase in the creative value of the products, which we interpreted from the Flow Theory.
Plücker coordinates of the best-fit Stiefel tropical linear space to a mixture of Gaussian distributions
Authors: Miura Keiji , Yoshida Ruriko 
Published: January 2023

AbstractIn this research, we investigate a tropical principal component analysis (PCA) as a best-fit Stiefel tropical linear space to a given sample over the tropical projective torus for its dimensionality reduction and visualization. Especially, we characterize the best-fit Stiefel tropical linear space to a sample generated from a mixture of Gaussian distributions as the variances of the Gaussians go to zero. For a single Gaussian distribution, we show that the sum of residuals in terms of the tropical metric with the max-plus algebra over a given sample to a fitted Stiefel tropical linear space converges to zero by giving an upper bound for its convergence rate. Meanwhile, for a mixtures of Gaussian distribution, we show that the best-fit tropical linear space can be determined uniquely when we send variances to zero. We briefly consider the best-fit topical polynomial as an extension for the mixture of more than two Gaussians over the tropical projective space of dimension three. We show some geometric properties of these tropical linear spaces and polynomials.
Evidencing built health system reconfiguration policy
Authors: Mills Grant Raymond Willton , García Antonio Rojas , Raine Rosalind 
Published: January 2023

Abstract
Background
Current built health system reconfiguration evidence is insufficient to support policy decisions on the best settings for healthcare provision. As a result, the “built health system” (the buildings, physical environments, engineering infrastructure and the building standards, guidance and evidence that support them) remain misunderstood. We explore several literature review types that have supported built health system policy, and the methodological, interdisciplinary and theoretical challenges of conducting high-impacting systematised reviews. Then establish how they might provide a robust basis for prioritising the reconfiguration of significant capital investments.

Methods/design
Five literature reviews undertaken to inform built health system reconfiguration policy are used as an empirical basis to help establish clearer scientific grounds for built health system infrastructure policy. The methods, benefits and empirical limitations of systematic, scoping, narrative, realistic and rapid reviews are compared.

Discussion
The methodological, interdisciplinary and theoretical shortcomings of existing evidence on built health system reconfiguration need to be addressed. This paper conceptualises this evidence and offers a new evidence co-production framework.
VIRGIL AND SALLUST:AENEID10.354–79 ANDBELLVM CATILINAE58–60
Authors: Woodman A.J. 
Published: January 2023

AbstractSince a problematic passage in Virgil'sAeneid(10.366–7) shows the same influence of Sallust (Cat.58–60) as do the dozen lines preceding and following, it should not be deleted, as has been suggested.