bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploration of microbial profile of traditional starters and its influence on aroma profile and quality of Chinese steamed bread
Authors: Wei Guanmian , Chitrakar Bimal , Wu Jiangna , Sang Yaxin 
Published: January 2023

AbstractBACKGROUNDChinese steamed bread (CSB) is a popular staple food in China with traditional ethnic characteristics. CSB with traditional starters has good flavor and texture but is unstable and requires a long preparation time. Therefore, it is necessary to analyze the traditional starters (ST) and their influence on the flavor and quality of steamed bread to meet people's requirements as a staple food.RESULTSThe count of yeast, lactic acid bacteria and total microbial population significantly varied in different traditional starters; Saccharomyces and Lactobacillus were the predominant genera. Among the tested samples, fungi were found in ST from Shijiazhuang (SJ), Handan (HD) and Langfang (LF), while bacteria were found in ST from Tangshan (TS) and SJ at sub‐predominant levels. In terms of the bread quality, the highest specific volume and porosity were in XT‐CSB (Xingtai); the highest height/diameter ratio was in SJ‐CSB; and the highest sensory score was in TS‐CSB. A total of 26 aroma compounds (VIP > 1; variable importance for predictive components) were identified to discriminate CSB fermented with different starters, which were separated by stepwise canonical discriminant analysis using two functions. The correlation analysis among microbiota, aroma compounds and bread quality showed a higher contribution of bacteria than of fungi.CONCLUSIONDifferences in microbial profiles caused different aroma profiles and quality of CSB; and the CSB fermented with traditional starters were sufficiently separated by stepwise canonical discriminant analysis based on aroma compounds. © 2023 Society of Chemical Industry.
Ternary eluent compositions in supercritical fluid chromatography improved fingerprinting of therapeutic peptides
Authors: Neumann Jonas , Schmidtsdorff Sebastian , Schmidt Alexander H. , Parr Maria K. 
Published: January 2023

Currently, little information has been published on the application of ternary eluent compositions in supercritical fluid chromatography for separating peptides. This work investigates the benefits of adding acetonitrile to methanol as the modifier. Three cyclic antibiotic peptides (bacitracin, colistin, and daptomycin) ranging between 1000 and 2000 Da were chosen as model substances. The ternary mixture of carbon dioxide, methanol, and acetonitrile is optimized to increase the resolution of the peptide's fingerprint. In addition, varying compositions of methanol and acetonitrile were found to change the elution order of the analytes, which is a valuable tool during method development. An individual gradient method using two Torus 2‐PIC columns (each 100 × 3.0 mm, 1.7 μm), carbon dioxide, and a modifier consisting of acetonitrile/methanol/water/methanesulfonic acid (60:40:2:0.1, v:v:v:v) was optimized for each of the peptides. Subsequently, a generic method development protocol applicable to polypeptides is proposed.
Patient Satisfaction and Acoustic Changes in Trans Women after Gender Affirming Voice Training
Authors: Rapoport Sarah K. , Varelas Eleni A , Park Christopher , Brown Sarah K. , Goldberg Leanne , Courey Mark S. 
Published: January 2023

ObjectivesGains in pitch from gender affirming voice training (GVT) alone in trans women have historically been shown to decline after 1 year. Currently no standard exists for length and type of GVT that yields meaningful behavioral change and patient satisfaction with voice outcomes in trans women. This study aims to determine whether GVT alone leads to sustained pitch elevation and patient satisfaction in trans women.MethodsRetrospective review from 2016 to 2020 of trans women patients who underwent GVT alone for voice change. Charts were reviewed for acoustic analysis of pitch including sustained vowel fundamental frequency, speaking fundamental frequency, and quality of life data from the Trans Woman Voice Questionnaire at pre‐therapy, immediate post‐therapy, and extended post‐therapy time intervals.ResultsA total of 157 patients presented to our Voice Center, of which 34 participated in the full course of GVT. Patients underwent an average of six sessions of GVT (range 5–7) over an average of 13.14 weeks (range 6–16). Average time between completing GVT and presenting for extended follow‐up was 11.37 months (range 6–31). Compared to initial presentation prior to therapy, at extended follow‐up after completing GVT average change in F0/a/, SF0, and TWVQ were 64.6 Hz, 31.3 Hz, and 32.45. No significant change was noted between immediate post‐therapy and extended post‐therapy acoustic measures. TWVQ demonstrated continued improvement between immediate post‐therapy and extended post‐therapy.ConclusionsIn self‐selected patients who present for extended follow‐up, GVT alone can result in sustained pitch elevation and voice‐related quality life in trans women.Level of Evidence4 Laryngoscope, 133:2340–2345, 2023
The impact of product defect severity and product attachment on consumer negative emotions
Authors: Wei Jiuchang , Jiang Ming , Li Yi‐Na , Li Wenjing , Mead James A. 
Published: January 2023

AbstractConsumers often experience negative emotions when confronted with a product defect. This is especially true when the product is integrated into many aspects of the consumer's life, such as the case with automotive vehicles. In this research, we draw on the consumer expectations and attachment literature to explore the impact of defect severity and product attachment, operationalized via both ownership length/usage (mileage) and the psychological construct of object attachment, on the negative emotions consumers experience. Using sentiment analysis of archived data of consumers' complaints from the Defective Product Administrative Center in China and a controlled experiment among US consumers, we find that defect severity and mileage/attachment interact in a novel curvilinear manner to influence the amount of negative emotion consumers experience. When defect severity is low, our results indicate a U‐shape relationship between mileage/attachment and negative emotions. However, when defect severity is high, an inverted U‐shaped relationship emerges. Furthermore, we link the specific emotion of anger to consumers' downstream perceptions (loyalty, quality, satisfaction, and more) of their vehicle, manufacturer, and retailer.
Clinical Diagnostic Accuracy of Parkinson's Disease: Where Do We Stand?
Authors: Virameteekul Sasivimol , Revesz Tamas , Jaunmuktane Zane , Warner Thomas T. , De Pablo‐Fernández Eduardo 
Published: January 2023

AbstractBackgroundClinical diagnostic accuracy of Parkinson's disease (PD) remains suboptimal. Changes in disease concept may have improved clinical diagnostic accuracy in the past decade. However, current clinical diagnostic criteria have not been validated against neuropathological confirmation.ObjectivesThis study aims to provide up‐to‐date clinical diagnostic accuracy data and validate current clinical diagnostic criteria for PD against neuropathology.MethodsA retrospective review of medical records of consecutive patients with parkinsonism from the Queen Square Brain Bank was performed between 2009 and 2019. Clinical diagnosis was documented at early (within 5 years of motor symptom onset) and final stages and categorized by movement disorder experts or regular clinicians. Movement Disorder Society Parkinson's disease (MDS‐PD) diagnostic criteria were retrospectively applied. Diagnostic accuracy parameters (sensitivity, specificity, positive/negative predictive value, and accuracy) were calculated using neuropathological diagnosis as the gold standard.ResultsA total of 267 patients (141 PD and 126 non‐PD parkinsonism) were included. Clinical diagnostic accuracy was 97.2% for experts, 92.5% for the MDS clinically probable PD criteria, and 90.3% for clinicians. Similar figures were obtained when applied at an early stage (91.5%, 89.5%, and 84.2% diagnostic accuracy, respectively). MDS clinically established early PD criteria demonstrated very high specificity (98.4%) at early stages.ConclusionsOur results showed an important improvement in PD clinical diagnostic accuracy in clinical practice over the past decade, more marked at early stages of the disease. MDS‐PD diagnostic criteria is a valid tool in clinical practice and research for the identification of PD patients showing excellent sensitivity and specificity, although movement disorder experts' diagnosis remains the gold standard PD diagnosis during life. © 2023 International Parkinson and Movement Disorder Society.
Microstructural parameters from DW‐MRI for tumour characterization and local recurrence prediction in particle therapy of skull‐base chordoma
Authors: Morelli Letizia , Palombo Marco , Buizza Giulia , Riva Giulia , Pella Andrea , Fontana Giulia , Imparato Sara , Iannalfi Alberto , Orlandi Ester , Paganelli Chiara , Baroni Guido 
Published: January 2023

AbstractBackgroundQuantitative imaging such as Diffusion‐Weighted MRI (DW‐MRI) can be exploited to non‐invasively derive patient‐specific tumor microstructure information for tumor characterization and local recurrence risk prediction in radiotherapy.PurposeTo characterize tumor microstructure according to proliferative capacity and predict local recurrence through microstructural markers derived from pre‐treatment conventional DW‐MRI, in skull‐base chordoma (SBC) patients treated with proton (PT) and carbon ion (CIRT) radiotherapy.MethodsForty‐eight patients affected by SBC, who underwent conventional DW‐MRI before treatment and were enrolled for CIRT (n = 25) or PT (n = 23), were retrospectively selected. Clinically verified local recurrence information (LR) and histological information (Ki‐67, proliferation index) were collected. Apparent diffusion coefficient (ADC) maps were calculated from pre‐treatment DW‐MRI and, from these, a set of microstructural parameters (cellular radius R, volume fraction vf, diffusion D) were derived by applying a fine‐tuning procedure to a framework employing Monte Carlo simulations on synthetic cell substrates. In addition, apparent cellularity (ρapp) was estimated from vf and R for an easier clinical interpretation. Histogram‐based metrics (mean, median, variance, entropy) from estimated parameters were considered to investigate differences (Mann‐Whitney U‐test, α = 0.05) in estimated tumor microstructure in SBCs characterized by low or high cell proliferation (Ki‐67). Recurrence‐free survival analyses were also performed to assess the ability of the microstructural parameters to stratify patients according to the risk of local recurrence (Kaplan‐Meier curves, log‐rank test α = 0.05).ResultsRefined microstructural markers revealed optimal capabilities in discriminating patients according to cell proliferation, achieving best results with mean values (p‐values were 0.0383, 0.0284, 0.0284, 0.0468, and 0.0088 for ADC, R, vf, D, and ρapp, respectively). Recurrence‐free survival analyses showed significant differences between populations at high and low risk of local recurrence as stratified by entropy values of estimated microstructural parameters (p = 0.0110).ConclusionPatient‐specific microstructural information was non‐invasively derived providing potentially useful tools for SBC treatment personalization and optimization in particle therapy.
Compensation for respiratory motion–induced signal loss and phase corruption in free‐breathing self‐navigated cine DENSE using deep learning
Authors: Abdi Mohamad , Bilchick Kenneth C. , Epstein Frederick H. 
Published: January 2023

PurposeTo introduce a model that describes the effects of rigid translation due to respiratory motion in displacement encoding with stimulated echoes (DENSE) and to use the model to develop a deep convolutional neural network to aid in first‐order respiratory motion compensation for self‐navigated free‐breathing cine DENSE of the heart.MethodsThe motion model includes conventional position shifts of magnetization and further describes the phase shift of the stimulated echo due to breathing. These image‐domain effects correspond to linear and constant phase errors, respectively, in k‐space. The model was validated using phantom experiments and Bloch‐equation simulations and was used along with the simulation of respiratory motion to generate synthetic images with phase‐shift artifacts to train a U‐Net, DENSE‐RESP‐NET, to perform motion correction. DENSE‐RESP‐NET‐corrected self‐navigated free‐breathing DENSE was evaluated in human subjects through comparisons with signal averaging, uncorrected self‐navigated free‐breathing DENSE, and breath‐hold DENSE.ResultsPhantom experiments and Bloch‐equation simulations showed that breathing‐induced constant phase errors in segmented DENSE leads to signal loss in magnitude images and phase corruption in phase images of the stimulated echo, and that these artifacts can be corrected using the known respiratory motion and the model. For self‐navigated free‐breathing DENSE where the respiratory motion is not known, DENSE‐RESP‐NET corrected the signal loss and phase‐corruption artifacts and provided reliable strain measurements for systolic and diastolic parameters.ConclusionDENSE‐RESP‐NET is an effective method to correct for breathing‐associated constant phase errors. DENSE‐RESP‐NET used in concert with self‐navigation methods provides reliable free‐breathing DENSE myocardial strain measurement.
Maternal anemia and the risk of childhood cancer: A population‐based cohort study in Taiwan
Authors: Orimoloye Helen T. , Qureshi Naveen , Lee Pei‐Chen , Wu Chia‐Kai , Saechao Chai , Federman Noah , Li Chung‐Yi , Ritz Beate , Arah Onyebuchi A. , Heck Julia E. 
Published: January 2023

AbstractBackgroundChildhood cancer may be related to maternal health in pregnancy. Maternal anemia is a common condition in pregnancy, especially in low‐income countries, but the association between maternal anemia and childhood cancer has not been widely studied.ObjectiveTo examine the potential relation between maternal anemia during pregnancy and childhood cancers in a population‐based cohort study in Taiwan.MethodsWe examined the relationship between maternal anemia and childhood cancer in Taiwan (N = 2160 cancer cases, 2,076,877 noncases). Cases were taken from the National Cancer Registry, and noncases were selected from birth records. Using national health registries, we obtained maternal anemia diagnoses. We estimated the risks for childhood cancers using Cox proportional hazard analysis.ResultsThere was an increased risk of cancers in children born to mothers with nutritional anemia (hazard ratio (HR): 1.32, 95% CI 0.99, 1.76). Iron deficiency anemia (HR: 1.30, 95% CI 0.97–1.75) carried an increased risk, while non‐nutritional anemias were not associated with childhood cancer risk.ConclusionOur results provide additional support for screening for anemia during pregnancy. Adequate nutrition and vitamin supplementation may help to prevent some childhood cancer.
“There's no playbook for when your kid has cancer”: Desired elements of an electronic resource to support pediatric cancer communication
Authors: Greenzang Katie A. , Scavotto Madison L. , Revette Anna C. , Schlegel Sarah F. , Silverman Lewis B. , Mack Jennifer W. 
Published: January 2023

AbstractIntroductionAcute lymphoblastic leukemia (ALL), the most common childhood malignancy, has a relatively favorable long‐term prognosis. Yet the complexity of treatment and the emotionality of the diagnosis leave families feeling unprepared for many aspects of therapy. This qualitative study aimed to identify desired elements and format of a communication resource to support patients and families facing a diagnosis of ALL.MethodsSemi‐structured interviews of 12 parents of children receiving ALL treatment, 10 parents of survivors of ALL, and eight adolescent and young adult (AYA) survivors of ALL were conducted between February and June 2021. The interviews focused on communication experiences throughout treatment and identified domains to be addressed in a resource in development.ResultsAll participants supported the development of an interactive, electronic health (eHealth) resource to help navigate ALL treatment. They felt a website would be helpful in addressing information gaps and mitigating pervasive feelings of overwhelm. Participants specifically sought: (a) information resources to address feelings of cognitive overload; (b) practical tips to help navigate logistical challenges; (c) clear depictions of treatment choices and trajectories to facilitate decision‐making; and (d) additional psychosocial resources and support. Two overarching themes that families felt should be interwoven throughout the eHealth resource were connections with other patients/families and extra support at transitions between phases of treatment.ConclusionsA new diagnosis of ALL and its treatment are extremely overwhelming. Patients and families unanimously supported an eHealth resource to provide additional information and connect them with emotional support, starting at diagnosis and extending throughout treatment.
Shear amplification of orientation in Nylon 11/clay nanocomposites during melt casting and resulting electrical properties
Authors: Jain Mayank , Mutlu Zeynep , Mao Jiahao , Zhou Jierui , Zhou Peinan , Wu Chao , Isik Tugba , Cao Yang , Ortalan Volkan , Cakmak Mukerrem 
Published: January 2023

AbstractIn this study, the effect of organically modified clay on the orientation enhancement in Nylon 11 in melt casting was investigated. Nylon 11 was mixed with 1 and 3 wt% Cloisite 20A using twin screw extrusion and they were cast into films with varying take‐up speeds. The addition of clay in Nylon 11 helped increase orientation levels substantially in melt cast films, both as a function of clay concentration as well as take‐up speeds. This was primarily due to shear amplification effect caused by the movement of adjacent clay nanoparticles due to the shear flow gradient within the die. At low clay concentrations, the sub‐Tm stretchability, and electrical breakdown strength improve as the presence of clay reduces inter/intrachain hydrogen bonding. At higher clay concentrations, both orientation and electrical breakdown levels decrease. The latter is primarily caused by increased percolation path of charge carriers. Nevertheless, clay nanoplatelets were very effective in their role as melt processing aids, as they enhance orientation levels of Nylon 11 thin films by shear amplification effect where they increase local chain orientation of chains trapped between clay platelets while their orientation relaxation is suppressed.
The prevalence of pulmonary hypertension after successful tuberculosis treatment in a community sample of adult patients
Authors: Louw Elizabeth , Baines Nicola , Maarman Gerald , Osman Muhammad , Sigwadhi Lovemore , Irusen Elvis , Koegelenberg Coenraad , Doubell Anton , Nathan Steven , Channick Richard , Allwood Brian 
Published: January 2023

AbstractThere are an estimated 155 million survivors of tuberculosis (TB). Clinical experience suggests that post tuberculosis lung disease (PTLD) is an important cause of Group 3 pulmonary hypertension (PH). However, TB is not listed as a cause of PH in most guidelines. A cross‐sectional, community‐based study was conducted in nonhealthcare seeking adults who had successfully completed TB treatment. Subjects underwent questionnaires, spirometry, a 6‐min walk distance test (6MWD) and transthoracic echocardiography (TTE). Screen probable PH was defined on TTE as an estimated pulmonary artery peak systolic pressure (PASP) of ≥40 mmHg. One hundred adults (71 males) were enrolled, with a mean age of 42 years (SD 13.8 years) and a median of one TB episode (interquartile range: 1–2). Co‐morbidities included hypertension (21%), diabetes (16%), human immunodeficiency virus (10%) and asthma/COPD (5%). Only 25% had no residual symptoms after TB. Probable PH was found in 9%, while 7% had borderline raised PASP values (PASP 35–40 mmHg). An association was found between PH and the number of previous TB episodes, with each additional episode of TB increasing the odds of PH‐postTB 2.13‐fold (confidence interval [CI]: 1.17–3.88; p = 0.013). All of those found to have PH were smokers or ex‐smokers yielding an unadjusted odds ratio for PH‐postTB of 3.67 (95% CI: 0.77–17.46). There was no statistical difference in spirometry or 6MWD, between those with and without PH. Neither symptoms nor co‐morbidities demonstrated significant association with PH. PH after TB was a common finding in this community‐based population. Further research is needed to confirm and determine the significance of these findings.
Coupling Engineering of NH4+ Pre‐Intercalation and Rich Oxygen Vacancies in Tunnel WO3 Toward Fast and Stable Rocking Chair Zinc‐Ion Battery
Authors: Tian Guofu , Wang Qi , Qu Zaiting , Yu Hao , Zhang Daohong , Wang Qiufan 
Published: January 2023

AbstractHerein, for the first time, a pre‐intercalated non‐metal ion (NH4+) with rich oxygen vacancies stabilized tunnel WO3 is proposed as a new intercalation anode to construct Zn‐metal‐free rocking‐chair ZIBs. With the ethylene glycol additive in the aqueous electrolyte, the Zn2+ solvation structure can be regulated and the side reaction of hydrogen evolution can also be suppressed. Owing to the integrated synergetic modification, a high‐rate and ultra‐stable aqueous Zn‐(NH4)xWO3 battery can be constructed, which exhibits an improved specific capacity (153 mAh g−1 at 0.1 A g−1), excellent rate performance (when the current density increases to 3 A g−1, the specific capacitance is still 86 mAh g−1), and a high cycle stability with 100% capacity retention after 2,200 cycles under 5 A g−1. Ex situ X‐ray diffraction and XPS reveal the reversible insertion/extraction of Zn2+ in (NH4)xWO3. The assembled (NH4)xWO3//MnO2 rocking‐chair ZIBs delivers excellent capacity of 82 mAh g−1 at 0.1 A g−1, impressive cyclic stability. Additionally, the flexible (NH4)xWO3//MnO2 ZIBs can power the electrochromic device‐based PANI/WO3 with high color contrast and fast response time. This study provides new insight for developing high‐performance rechargeable aqueous ZIBs.
Electronic Structure‐Dependent Water‐Dissociation Pathways of Ruthenium‐Based Catalysts in Alkaline H2‐Evolution
Authors: Yang Chengdong , Wu Zihe , Zhao Zhenyang , Gao Yun , Ma Tian , He Chao , Wu Changzhu , Liu Xikui , Luo Xianglin , Li Shuang , Cheng Chong , Zhao Changsheng 
Published: January 2023

AbstractRuthenium (Ru)‐based catalysts have displayed compelling hydrogen evolution activities, which hold the promising potential to substitute platinum in alkaline H2‐evolution. In the challenging alkaline electrolytes, the water‐dissociation process involves multistep reactions, while the profound origin and intrinsic factors of diverse Ru species on water‐dissociation pathways and reaction principles remain ambiguous. Here the fundamental origin of water‐dissociation pathways of Ru‐based catalysts in alkaline media to be from their unique electronic structures in complex coordination environments are disclosed. These theoretical results validate that the modulated electronic structures with delocalization‐localization coexistence at their boundaries between the Ru nanocluster and single‐atom site have a profound influence on water‐dissociation pathways, which push H2O* migration and binding orientation during the splitting process, thus enhancing the dissociation kinetics. By creating Ru catalysts with well‐defined nanocluster, single‐atom site, and also complex site, the electrocatalytic data shows that both the nanocluster and single‐atom play essential roles in water‐dissociation, while the complex site possesses synergistically enhanced roles in alkaline electrolytes. This study discloses a new electronic structure‐dependent water‐dissociation pathway and reaction principle in Ru‐based catalysts, thus offering new inspiration to design efficient and durable catalysts for the practical production of H2in alkaline electrolytes.