bluuebunny/crossref_metadata_2025_split huggingface dataset:
APPLICATIO OF SCIENCE AND TECHNOLOGY IN DEVELOPING OF CACTUS PLANTS TO INCREASE PUBLICK KNOWLEDGE AND INCOME
Authors: Munandar Denna Eriani , Sundahri Sundahri 
Published: July 2023

Cactus plants are ornamental plants that have many benefits and high value so they are profitable when developed. The Faculty of Agriculture, University of Jember has developing a lot of horticultural plants including ornamental plants such as cactus plants. The partner of these program is the owner of the ornamental plant business "Kartini Nursery" located in Kepatihan Village, Kaliwatesi District,Jember which has problems abaout benefits, propagation, maintenance and making an attractive appearance of cactus plant that can be display and sold. The purpose of this program was to increase knowledge and technology of partner programme regarding the benefits, methods of propagation, and maintenance of cactus plants,, to produce hight quality and attractive plants wich have high economic value. The programme carried out using socialization and practice method of propagation, maintenance and planting of cactus plants tiny plants in pots or mini gardens.The evaluation is carried out during the implementation and at the end of the activity. The results of the activities showed that the activity runs smoothly, the partners are very enthusiastic in participating in each stage of the programme and planting cactus in mini pots. Conclusion of the activities, partners knowledge and technology increased in the developing, maintenance and planting provitable cactus in beautiful pots.
Analisis Perbandingan Motivasi Kerja, Kedisiplinan, dan Kreativitas Guru di SD Negeri Se-Kecamatan Dolopo Berdasarkan Status Kepegawaian
Authors: Yenny Ika Fatmasari  , Andhita Dessy Wulansari  
Published: July 2023

Keberhasilan suatu pendidikan tentu saja tidak lepas dari peran serta pemerintah dan komponen pendidikan yang terkait, salah satunya yaitu guru. Seiring dengan perkembangan zaman, maka guru dituntut untuk memiliki kompetensi unggul dalam perannya mewujudkan tujuan pendidikan nasional. Motivasi kerja, kedisiplinan dan kreativitas guru dalam mengajar sangat diperlukan untuk mencapai kinerja yang tinggi. Penelitian ini menggunakan pendekatan kuantitatif. Populasi dalam penelitian ini adalah guru PNS dan Non PNS di 28 SD Negeri se-Kecamatan Dolopo dengan jumlah sampel 87 guru PNS dan 66 guru Non PNS. Data yang diperoleh dari penelitian diuji prasyaratkan terlebih dahulu dengan uji normalitas multivariat dan uji homogenitas matriks varian-kovarian/Box’s M, kemudian dianalisis menggunakan uji MANOVA (Multivariate of Analisys). Penelitian ini bertujuan untuk mengetahui perbedaan motivasi kerja pada guru PNS dan Non PNS di SDN se-Kecamatan Dolopo, untuk mengetahui perbedaan kedisiplinan pada guru PNS dan Non PNS di SDN se-Kecamatan Dolopo, untuk mengetahui perbedaan kreativitas pada guru PNS dan Non PNS di SDN se-Kecamatan Dolopo, dan untuk mengetahui perbedaan motivasi kerja, kedisiplinan dan kreativitas secara simultan pada guru PNS dan Non PNS di SDN se-Kecamatan Dolopo. Hasil penelitian ini adalah: 1) tidak terdapat perbedaan motivasi kerja pada guru PNS dan Non PNS di SDN se-Kecamatan Dolopo dengan nilai probabilitas 0,075. 2) tidak terdapat perbedaan kedisiplinan pada guru PNS dan Non PNS di SDN se-Kecamatan Dolopo dengan nilai probabilitas 0,1571. 3) tidak terdapat perbedaan kreativitas guru PNS dan Non PNS di SDN se-Kecamatan Dolopo dengan nilai probabilitas 0,279. 4) tidak terdapat perbedaan motivasi kerja, kedisiplinan dan kreativitas secara simultan pada guru PNS dan Non PNS di SDN se-Kecamatan Dolopo dengan nilai probabilitas 0,336.
An artesunate pharmacometric model to explain therapeutic responses in falciparum malaria
Authors: Saralamba Sompob , Simpson Julie A , Choosri Noppon , White Lisa , Pan-Ngum Wirichada , Dondorp Arjen M , White Nicholas J 
Published: July 2023

Abstract

Background
The artemisinins are potent and widely used antimalarial drugs which are eliminated rapidly. A simple concentration-effect pharmacometric model does not explain why dosing more frequently than once daily fails to augment parasite clearance and improve therapeutic responses in-vivo. Artemisinins can induce a temporary non-replicative or “dormant” drug refractory state in Plasmodium falciparum malaria parasites which may explain recrudescences observed in clinical trials despite full drug susceptibility, but whether it explains the dosing-response relationship is uncertain.
Objectives
To propose a revised model of antimalarial pharmacodynamics which incorporates reversible asexual parasite injury and temporary drug refractoriness in order to explain the failure of frequent dosing to augment therapeutic efficacy.
Methods
The model was fitted using Bayesian Markov Chain Monte Carlo approach with the parasite clearance data from 39 patients with uncomplicated falciparum malaria treated with artesunate from western Cambodia and 40 patients from Northwestern Thailand reported previously.
Results
The model captured the dynamics of parasite clearance data. Its predictions are consistent with observed therapeutic responses.
Conclusions
A within-host pharmacometric model is proposed in which it is hypothesised that some malaria parasites enter a temporary drug refractory state after exposure to artemisinin antimalarials which is followed by delayed parasite death or reactivation. The model fitted the observed sequential parasite density data from patients with acute P. falciparum malaria, and it supported reduced ring stage activity in artemisinin resistant infections.
Recommendation Modelling based on Contextual Weather Data in an Adaptive Coaching System: A Semantic and Explainable Approach
Authors: Chatterjee Ayan , Ganesh K , Pahari Nibedita , Riegler Michael A. 
Published: July 2023

Abstract
Physical activities are of two types-indoor and outdoor. Outdoor exercise is an enjoyable way for individuals to improve their fitness; however, it depends on the weather. Staying active year-round can help to maintain strength, control weight gain, and improve overall health. The weather has been identified as a barrier to physical activity participation. The adverse weather conditions are most important to lead to reduced physical activity. As cold, rainy, foggy, and snowy weather settles in, individual exercise and physical activity may begin to decrease. The effects of heat stress and/or dehydration may lead to decreased physical activities. Physical activity is stressful in high ambient temperature and humidity. Cold injuries are a common result of exposure to cold during physical activities. Many people engage in physical fitness programs year-round in cold, wet or windy conditions (or a combination thereof), putting themselves at risk of injury from the cold. In this regard, a continuous evidence-based and goal-oriented monitoring system can be beneficial to guide people with automatic personalized recommendation generation to perform either indoor or outdoor activities based on the probabilistic distribution of external weather data. In this research, we have conceptualized the design of an automatic coaching system (eCoaching) that can generate recommendations based on the processing of contextual external weather data. Moreover, we have proposed an algorithm to annotate collected data, process and classify them, generate recommendations, and semantically represent the obtained knowledge using an Ontology. For the overall experiment, we collected weather data variations for one and a half years from thirteen cities of the Southern-Norway. Followed by, we added rule for indoor and outdoor activity types. The classification performance has been evaluated using the metrics such as accuracy, precision, recall, F1-score, brier-score, and Mathew’s coefficient (MCC) and achieves 99.99% accuracy with DecisionTree Classifier. Moreover, we used SHapley Additive exPlanations (SHAP) and Local Interpretable Model-Agnostic Explanations (LIME) to explain the classifications. The consistency of the Ontology model has been evaluated with reasoners and reasoning time. The Ontology model has been useful for semantic representation of collected and processed data, and the rule-based recommendation modeling with machine learning algorithm, a knowledge base and description logics.
Adaptive High-order Sliding Mode Control for Vibration Displacement System of Continuous Casting Mold
Authors: Yuan Na , Ma Zhuang , Zhou Jian 
Published: July 2023

Abstract
To solve the non-unique problem of inverse solutions of nonlinear periodic function and the uncertainties in the transmission mechanism of vibration displacement system of continuous casting mold driven by servo motor, an adaptive high-order sliding mode control(HOSMC) strategy based on nonlinear processing method is proposed. Firstly, a new nonlinear processing method is utilized to solve the problem that the output equation of the system has the non-unique problem of inverse solutions of a nonlinear periodic function, which is convenient for the controller design of displacement loop. Secondly, an adaptive HOSMC controller is proposed to suppress the uncertainties including the initial zero position deviation of the eccentric shaft, parameter perturbation, and fast time-varying load disturbance, and track the desired displacement accurately in the displacement loop system, and it is proved that the displacement tracking error is stable and convergent to the near origin in finite time. Finally, the simulation and experimental researches are all verified that the proposed control method is superior to the PI control method in the field and has better dynamic and steady-state tracking performance.
Insight into the Environmental Fate, hazard, Detection, and Sustainable Degradation Technologies of Chlorpyrifos - An Organophosphorus Pesticide
Authors: Kumar Pankaj , Arshad Muhammad , Gacem Amel , Soni Sunil , Singh Snigdha , Kumar Manoj , Yadav Virendra Kumar , Tariq Mohd , Kumar Ramesh , Shah Deepankshi , Wanale Shivraj Gangadhar , Mesfer Mohammed Khaloofah Mola Al , Bhutto Javed Khan , Yadav Krishna Kumar 
Published: July 2023

Abstract

Pesticides play a critical role in terms of agricultural output nowadays. On top of that, pesticides provide economic support to our farmers. However, the usage of pesticides has created a public health issue and environmental hazard. Chlorpyrifos, an organophosphate pesticide, is extensively applied as an insecticide, acaricide, and termiticide against pests in a variety of applications. Environmental pollution has occurred because of the widespread usage of chlorpyrifos, and it is harming several ecosystems including soil, sediment, water, air, and biogeochemical cycles. While residual levels in soil, water, vegetables, foodstuffs, and human fluids have been discovered, chlorpyrifos has also been found in the sediment, soil, and water. The irrefutable pieces of evidence indicate that chlorpyrifos exposure inhibits the choline esterase enzyme, which impairs the ability of the body to use choline and as a result, neurological, immunological, and psychological consequences are seen in people and the natural environment. Several research studies have been conducted worldwide to identify and develop chlorpyrifos remediation approaches and its derivatives from the environment. Currently, many detoxification methods are available for pesticides such as chlorpyrifos, but recent research has shown that the breakdown of chlorpyrifos using bacteria is the most proficient, cost-effective, and sustainable. This current article aims to outline relevant research events and provide a summary of the possible breakdown of chlorpyrifos into a variety of compounds, along with a discussion of analytical summaries of current research findings on bacterial degradation of chlorpyrifos and the potential degradation mechanism.
The effect of smartphone distraction on depression among Chinese nursing students: the mediating role of rumination and social withdrawal
Authors: Li Chaoyang , Wu Man , Zeng Lijuan , Zhao Xueyang , Yu Yiqing , Hu Ting , Yang Fen , Han Yang Yang 
Published: July 2023

Abstract
Background
Smartphones have fully penetrated into the daily life of Chinese nursing students. While smartphones bring convenience to nursing students, they have also become an important risk factor for depression among nursing students. Among them, smartphone distraction is closely related to depression, and the prevalence of smartphone distraction among nursing students is gradually increasing. However, the potential mechanism of the effect of smartphone distraction on nursing students' depression is unclear.
Methods
A cross-sectional study design was used in this study. This study conducted an online questionnaire survey of undergraduate nursing students from several universities in Wuhan between September 2021 and May 2022. A total of 574 nursing students completed an online questionnaire in this study, which measured their levels of smartphone distractions, rumination, social withdrawal, and depression. The data were analyzed in this study using SPSS 25 and PROCESS 4.2.
Results
Smartphone distraction among nursing students had an impact on depression through four pathways: (1) Smartphone distraction significantly positively predicted depression (β = 0.353, P < 0.001); (2) Rumination (β = 0.199, 95% CI: 0.081 to 0.162) and social withdrawal (β = 0.061, 95% CI: 0.034 to 0.091) mediate the effects of smartphone distractions on depression, respectively; and (3) Rumination and social withdrawal played a chain mediating role in the effect of smartphone distractions on nursing students’ depression (β = 0.027, 95% CI: 0.015 to 0.042).
Conclusion
The negative impact of smartphone distraction on nursing students' mental health should not be taken lightly. Both schools and families should guide nursing students to use smartphones correctly and keep abreast of their motivation and thinking dynamics; enhance their social connection and social skills to reduce their risk of depression.
Determinants of common mental disorders among residents of Quiha town, Tigray, Northern Ethiopia: a case-control study
Authors: Mebrahtu Kalayu , Tesfay Kenfe , Sied Jemal , Girmay Bereket 
Published: July 2023

Abstract
Background: Common mental disorder (anxiety and depression) are the most prevalent mental disorders in the world. The study aimed to identify the determinants of common mental disorders among residents of Quiha town, northern Ethiopia.
Methods: A community based unmatched case-control study was employed with a total of 297 study subjects (99 cases and 198 controls) in Quiha town. Common mental disorder was measured by the self-reported questionnaire (SRQ 20) scale. Bivariate and multiple logistic regression analyses were performed to determine between the independent and dependent variables.
Result: The study shows that participants who were Son/daughter (AOR = 0.37, 95% CI:0.14 - 98, P= 0.046) and being dependent (AOR = 6.50, 95% CI:1.17 - 36.20, P = 0.033), chronic illness (AOR = 2.52; 95% CI: 1.10 - 5.80, P = 0.030), stressful life event (AOR = 2.50; 95% CI: 1.20 - 5.13, P = 0.012), moderate stress level (AOR = 5.92; 95% CI:2.85 - 12.27, P = 0.000 ) and high perceived stress level (AOR= 122.82; 95% CI: 114.83 - 1063.60, P = 0.000) were significant factors of common mental disorders.
Conclusion:Factors like son/daughter, dependent, chronic illness, experiencing stressful life events, moderate and high perceived stress levels were significant factors of with common mental disorders.
Future Hydropower Expansion in Eco-Sensitive River Basins under Global Energy-Economic Change
Authors: Chowdhury AFM Kamal , Wild Thomas , Zhang Ying , Binsted Matthew , Iyer Gokul , Kim Son , Lamontagne Jonathan 
Published: July 2023

Abstract
Vast hydropower resources remain untapped globally, the deployment of which could provide energy-economic benefits but impact riverine ecosystems. Across eco-sensitive river basins, it is unclear how drivers of hydropower expansion, such as rapid economic growth and a low-carbon energy transition, could interact with countervailing forces, such as increasingly cost-competitive variable renewable energy (VRE). Using an integrated energy-water-economy model, we explore the effects of these forces on long-term hydropower expansion in the world's 20 most eco-sensitive basins, which have high ecological richness and untapped hydropower potential. We find that a low-carbon transition exerts the strongest development pressure, causing deployment exceeding 80% of exploitable potential in more than 72% of eco-sensitive basins by 2050, most of which have limited deployment today. Rapid economic growth induces such extensive deployment in only 44% of eco-sensitive basins. Enhanced integration of VRE reduces deployment, alleviating the impacts of rapid economic growth but not the low-carbon transition.
Green cocoon-derived sericin reduces cellular damage caused by radiation in human keratinocytes
Authors: Kakihara Nahoko , Sato Mami , Sato Momoko , Koguchi Mizuki , Yamauchi Shiori , Nakano Toshimichi , Sasamoto Ryuta , Sato Hideyo 
Published: July 2023

Abstract
Radiation therapy used in the treatment of cancer causes skin damage, and no method of care has been established thus far. Recently, it has become clear that sericin derived from silkworm cocoons has moisturizing and antioxidant functions. In addition, green cocoon-derived sericin, which is rich in flavonoids, may have enhanced functions. However, whether this green cocoon-derived sericin can reduce radiotherapy-induced skin damage is unclear. In the present study, we aimed at establishing care methods to reduce skin cell damage caused by X-irradiation using green cocoon-derived sericin. We investigated its effect on human keratinocytes using lactate dehydrogenase activity to indicate damage reduction. Our results showed that green cocoon-derived sericin reduced cell damage caused by X-irradiation. However, this effect was not observed when cells were treated before X-irradiation or with a sericin derived from white cocoons. In addition, dialysis-treated green cocoon-derived sericin decreased cytotoxicity-reducing effect. Our results suggest that green cocoon sericin mitigates the damaging effect of X-irradiation on cells, hence presenting potential usefulness in reducing skin damage from radiation therapy and opening new avenues in the care of cancer patients.
A Phase 3 Randomized Precision Medicine Clinical Trial Using Low-Dose Ondansetron (a 5-HT3 Antagonist) to Treat Alcohol Use Disorder
Authors: Johnson Bankole , Alho Hannu , Addolorato Giovanni , Lesch Otto , Chick Jonathan , Liu Lei , Reich Jack , Schuyler Vinzant , Rodd Zachary 
Published: July 2023

Abstract
Genetic predisposition may determine treatment response in alcohol use disorder (AUD). This 6-month, double-blind, randomized trial assessed ondansetron (0.33 mg twice daily; AD04) in genotype-specific AUD subjects stratified by drinking endophenotype (<10 (‘heavy’) or ≥10 (‘severe’) drinks per drinking day). In heavy drinkers, at study end (Month 6), the least-squares (LS) mean change in percentage of heavy drinking days from baseline was 8.5% greater with AD04 vs. placebo treatment (LS mean (standard deviation): -46.7% (2.7%) vs. -38.1% (2.9%); p<0.03), with a non-significant effect (LS mean difference: 7.0%, p=0.07) for Months 5 and 6 combined. AD04 vs. placebo treatment increased quality of life (odds ratio=3.4, 95% Confidence Interval: 1.03-11.45; p=0.04) and reduced AUD symptoms (mild symptoms: 33% vs. 39%; severe symptoms: 10% vs. 24%; p=0.05). AD04 had a similar adverse events profile to placebo. ADO4 showed promise as a precision medicine treatment for genotype-specific heavy drinkers.
Psychosocial dimensions of access and their association with contraceptive use and intention to use
Authors: ZAN Lonkila Moussa , ROSSIER Clementine 
Published: July 2023

Abstract
Background
Several studies suggest that psychosocial accessibility appears to be the key remaining hurdle to contraceptive use when issues of geographic and financial accessibility have been resolved. To date, the literature has considered various dimensions of psychosocial accessibility, which are not well measured by the two main sources of contraceptive data (DHS and PMA2020). In a previous work, we have designed a framework that outlines four subdimensions of cognitive and psychosocial accessibility and their theoretical relationship to contraceptive use and intention to use. This paper aims to study the associations between the cognitive and psychosocial dimensions of access to contraception with the contraceptive use and intention to use. It also aims to explore the mediation effect of psychosocial dimensions of access in the relationships between classical individual characteristics and contraceptive use and intention to use.
Methods
Data we used came from the 6th round of the PMA2020 survey in Burkina Faso in 2018–19. This survey included 2,763 households (98.4% response rate) and 3329 women (97.7% response rate). In addition to PMA's core questions, this survey collected data on psychosocial accessibility. Each group of questions was added to address one dimension. We use a multilevel generalized structural equation and mediation modeling to test the associations between psychosocial accessibility and contraceptive use, while controlling for other individual and contextual characteristics.
Results
Approval, contraceptive knowledge, and agency were associated with contraceptive use, while fears of side effects were not. Approval and agency explain part of the effects of education and parity on contraceptive use. Diffusion FP message had a positive effect on women contraceptive agency.
Conclusion
FP messages can help enhance women contraceptive agency, and then, contraceptive use, regardless of women age and parity. The analysis highlights the mediator effects of contraceptive approval and agency on the relationship between parity, and education and contraceptive use. It also confirms the effects of FP messages on women's contraceptive agency.
Treatment patterns and outcomes of BCG-treated non-muscle invasive bladder cancer patients in Germany
Authors: Doobaree Indraraj Umesh , Quignot Nadia , Jiang Heng , Lehmann Jan , Khachatryan Artak , Ghatnekar Ola 
Published: July 2023

Abstract
Background: Non-muscle-invasive bladder cancer (NMIBC) has a high rate of recurrence and progression. Nearly half of patients become unresponsive to guideline-recommended intravesical Bacillus Calmette-Guérin (BCG) treatment. We aimed to describe contemporary treatment patterns and outcomes of BCG-treated patients in Germany.
Methods: This observational, retrospective cohort study using German statutory health insurance data included NMIBC patients who received BCG instillation between 1st January 2012 and 31st December 2017. Patients were followed from BCG initiation for treatment patterns and from final BCG instillation for recurrence, progression to muscle-invasive bladder cancer (MIBC), death or end of follow-up (31st December 2019).
Results: Most of the BCG-treated cohort (N=1,049) were male with a mean age of 70.4 years. Overall, patients received a median (interquartile range) of 12.0 (6.0 – 18.0) BCG instillations over a median duration of 9.8 (2.3 – 21.3) months. After receipt of their final BCG instillation (median follow-up from final BCG instillation: 2.5 years), 57% of patients did not receive any further treatment while 11% had at least one evidence record of NMIBC recurrence and 30% progressed to MIBC. Among the 353 patients who received treatment following their final BCG instillation, 33% received mitomycin and 37% underwent a radical cystectomy.
Conclusions: A substantial proportion of patients with NMIBC who received further treatment after their final BCG instillation underwent a radical cystectomy, and one third were treated with mitomycin; treatment options after mitomycin varied. Findings from this study suggest an unmet need for optimal treatments for BCG-unresponsive patients who are at higher risk of recurrence but unable or unwilling to undergo radical cystectomy.