bluuebunny/crossref_metadata_2025_split huggingface dataset:
Resilience and its relationship with quality of life and comorbid substance use disorder in patients with type I bipolar disorder
Authors: Moustafa Shady Mohamed , Aldin Magda Taha Kamal , Sayed Haydy Hassan , Hendi Ahmed Elarabi 
Published: January 2025

Abstract

Background
Bipolar disorders (BD) are common psychiatric disorders. Stressful life events as well as comorbid Substance use disorders contribute to functional impairment in patients with BD. This study aimed to assess resilience and its relation to quality of life and severity of comorbid substance use disorders in patients with type I bipolar disorder.
Sixty six type I bipolar disorder patients—currently in remission—were categorized into two groups: a group including 33 patients were compared to a sociodemographically matched group of 33 patients of similar disease related clinical variables with comorbid substance use disorder. Resilience, quality of life and severity of addiction were assessed for both groups.

Results
Resilience level was found to be significantly lower in bipolar with comorbid substance use group compared to bipolar group. Quality of life of bipolar patients with comorbid substance use was not only significantly impaired but also positively correlated to resilience level. There was a strong negative correlation between resilience level and all aspects of addiction severity in patients with type I bipolar disorder.

Conclusion
Level of resilience was found to be positively correlated to quality of life and negatively correlated to severity of comorbid substance use in patients with type I bipolar disorder.
Effects of Cirsium japonicum var. maackii on avelliation of metabolic disease by improving insulin resistance
Authors: Yoon Hye-Bin , Jang Yuseong , Paik Hyeon-Gi , Choi Hwal , Choi Jihye , Kwon Jungkee 
Published: January 2025

Abstract

Background
Metabolic syndrome (MetS) refers to a group of risk factors that cause health problems, such as obesity, diabetes, dyslipidemia, and hyperglycemia. MetS is characterized by insulin resistance, which leads to abnormal insulin sensitivity. Cirsium japonicum var. maackii (CJ) is perennial herbaceous species found in Asia that exhibits antioxidant, antidiabetic, antitumor, antifungal, and anti-inflammatory activities. In this study, we aimed to measure the effects of CJ on MetS by improving insulin resistance in a db/db type 2 diabetes mouse model. After administrating CJ extract (CJE) for db/db mouse for 6 weeks, we measured with the evaluation of Insulin resistance, lipid profiles, histological analysis of liver, damage of liver and kideny.

Results
The results showed that CJE was effective in reducing body weight and fat mas and showed a positive effect on lowering blood glucose and improving insulin sensitivity. CJE improved dyslipidemia by increasing serum-HDL levels and decreasing serum-LDL levels. In addition, CJE reduced liver and kidney damage in histological analysis.

Conclusions
These results demonstrate the anti-diabetic effects of CJE and suggest its potential for improving MetS. Therefore, CJE may have potential values as a functional food material for managing MetS.
Conducting Clinical Research in Low Research Resource Countries: Lessons Learned From the International Registry of Men With Advanced Prostate Cancer Study in Nigeria
Authors: Bolajoko Opeyemi , Fathi Parisa , Fulwood Dottington , Toye Oluwaseyi , Popoola Ademola , Dogo Hassan , Nggada Haruna , Ogo Chidiebere , Fatiregun Omolara , Faruk Mohammed , Abiodun Lateef , Sowunmi Anthonia , Oladoyinbo Catherine A. , Odedina Folakemi 
Published: January 2025

PURPOSE
There is limited cancer clinical research in sub-Saharan African countries despite the significant burden of cancers. The primary objective of this strengths, weaknesses, opportunities, and threats (SWOT) analysis was to understand and document factors affecting the successful implementation of prostate cancer (CaP) clinical research in Nigeria.

METHODS
The research team used a qualitative design involving International Registry of Men with Advanced Prostate Cancer (IRONMAN) study team members as participants from four regional sites in Nigeria. One-hour listening sessions were conducted via Zoom at each site, focusing on SWOT related to the IRONMAN study. All sessions were recorded, transcribed, and analyzed. Themes were inductively coded and then synthesized across all four sites.

RESULTS
The study teams identified several strengths and weaknesses in conducting the IRONMAN study at their respective sites. Key strengths included access to robust patient population for recruitment and the availability of essential resources, such as lab space, clinical knowledge, and adequate staffing. Weaknesses centered on the social determinants of health that hinder patient participation, such as transportation challenges, distance to clinics, limited access to care, and insufficient biorepository space for sample storage. A prominent opportunity identified was the potential for Nigerian institutions to engage in more clinical research, particularly multisite global trials. Threats included difficulties in retaining research staff and political instability.

CONCLUSION
This study highlights the promising research opportunities in Nigeria. The lessons learned from the IRONMAN study provide valuable insights into the feasibility of conducting CaP clinical research and trials tailored to the needs of Black men in sub-Saharan Africa. These findings offer a roadmap for future research efforts, with the potential to expand clinical trials and improve health outcomes across the region.
Social Media Mentions are a Stronger Predictor of Citations than 5-Year Impact Factor in Neurosurgical Research
Authors: Behal Aditya , Gajjar Avi A. , Srinivasan Aditya , Burkhardt Jan-Karl , Field Nicholas C. , Paul Alexandra R. 
Published: January 2025

BACKGROUND AND OBJECTIVES:
X (formerly known as Twitter) is a social media platform gaining popularity in neurosurgery. Other disciplines have demonstrated a positive correlation between Twitter activity and traditional citation metrics. This study aims to determine if X activity is a greater predictor of citation rates than a journal's 5-year impact factor (IF) among major neurosurgical journals.

METHODS:
Using a mixed linear model, we compared the predictive value between alternative metrics (such as mentions on X and Altmetric attention score, a weighted aggregate of the attention an article receives on various platforms) and traditional citation metrics (5-year journal IF) on the number of citations an article received by analyzing 7592 articles published from January 2022 to December 2023 in 18 neurosurgical journals. It was necessary to also account for the confounding variable time since publication in the model to determine the true effect of altmetrics. The relative importance (RI) of each predictor variable was determined through permutation testing.

RESULTS:
X mentions, time since publication, 5-year journal IF, and Altmetric attention score all significantly predict citation rates (P < .001). RI of X mentions on citation rates indicate that X (RI = 0.13) is approximately 8.7x times greater of a predictor of citations than 5-year IF (RI = 0.015) and 5.4x times greater of a predictor than the Altmetric attention score (RI = 0.024). Time of publication remains the strongest predictor (RI = 0.83).

CONCLUSION:
Our study shows that in neurosurgical research, while social media mentions (X mentions) are significant, they are weaker predictors of citation rates than time since publication. Traditional journal IF and Altmetric attention scores have weaker predictive value. These findings indicate that altmetrics, especially X mentions, can complement traditional citation metrics.
Augmenting Large Language Models With Automated, Bibliometrics-Powered Literature Search for Knowledge Distillation: A Pilot Study for Common Spinal Pathologies
Authors: Kurland David B. , Alber Daniel A. , Palla Adhith , de Souza Daniel N. , Lau Darryl , Laufer Ilya , Frempong-Boadu Anthony K. , Kondziolka Douglas , Oermann Eric K. 
Published: January 2025

BACKGROUND AND OBJECTIVES:
Scholarly output is accelerating in medical domains, making it challenging to keep up with the latest neurosurgical literature. The emergence of large language models (LLMs) has facilitated rapid, high-quality text summarization. However, LLMs cannot autonomously conduct literature reviews and are prone to hallucinating source material. We devised a novel strategy that combines Reference Publication Year Spectroscopy—a bibliometric technique for identifying foundational articles within a corpus—with LLMs to automatically summarize and cite salient details from articles. We demonstrate our approach for four common spinal conditions in a proof of concept.

METHODS:
Reference Publication Year Spectroscopy identified seminal articles from the corpora of literature for cervical myelopathy, lumbar radiculopathy, lumbar stenosis, and adjacent segment disease. The article text was split into 1024-token chunks. Queries from three knowledge domains (surgical management, pathophysiology, and natural history) were constructed. The most relevant article chunks for each query were retrieved from a vector database using chain-of-thought prompting. LLMs automatically summarized the literature into a comprehensive narrative with fully referenced facts and statistics. Information was verified through manual review, and spine surgery faculty were surveyed for qualitative feedback.

RESULTS:
Our tandem approach cost less than $1 for each condition and ran within 5 minutes. Generative Pre-trained Transformer–4 was the best-performing model, with a near-perfect 97.5% citation accuracy. Surveys of spine faculty helped refine the prompting scheme to improve the cohesion and accessibility summaries. The final artificial intelligence–generated text provided high-fidelity summaries of each pathology's most clinically relevant information.

CONCLUSION:
We demonstrate the rapid, automated summarization of seminal articles for four common spinal pathologies, with a generalizable workflow implemented using consumer-grade hardware. Our tandem strategy fuses bibliometrics and artificial intelligence to bridge the gap toward fully automated knowledge distillation, obviating the need for manual literature review and article selection.
Impact of Disability on Postoperative Outcomes After Gastrointestinal Cancer Surgery
Authors: Zindani Shahzaib , Khalil Mujtaba , Woldesenbet Selamawit , Rashid Zayed , Altaf Abdullah , Kawashima Jun , Schenk Austin , Pawlik Timothy M. 
Published: January 2025

Abstract

Introduction
Approximately 61 million individuals in the United States have a disability and face unique challenges, resulting in healthcare disparities.

Objective
We aimed to evaluate the impact of disability on postoperative outcomes and number of healthy days at home (HDAH).

Methods
Patients who underwent surgery for gastrointestinal (GI) cancer between 2017 and 2020 were identified using the Medicare database. Multivariable regression models were used to examine the association between disability and postoperative complications, discharge disposition, and the number of HDAH.

Results
A total of 72,452 individuals underwent GI cancer surgery (pancreas: n = 7614, 10.5%; hepatobiliary: n = 4994, 6.9%; colorectal: n = 59,844, 82.6%). Median patient age was 75 years (interquartile range 71–81) with most patients being female (n = 37,167, 51.3%). Overall, 5432 individuals (7.2%) had a disability. Following surgery, patients with a disability were more likely to experience complications (4.6% vs. 3.3%), be discharged to a skilled nursing facility (SNF; 26.6% vs. 12.3%), and experience hospital readmission (20.0% vs. 13.5%) [all p < 0.001]. Consequently, individuals with disabilities were more likely to spend fewer (<20th percentile) HDAH (33% vs. 19.2%) [all p < 0.001]. On multivariable analysis, disability was associated with higher odds of complications (odds ratio [OR] 1.36, 95% confidence interval [CI] 1.19–1.56) and hospital readmission (OR 1.55, 95% CI 1.44–1.66). Additionally, disability was associated with higher odds of spending fewer HDAH (OR 1.88, 95% CI 1.77–1.99).

Conclusion
Following GI cancer surgery, individuals with disabilities had a higher risk of complications and spent fewer HDAH. There is a need for targeted interventions to improve the care of patients with disabilities and ensure equitable oncological and surgical outcomes.
Understanding the social return on investment of physical activity and sport: developing an international consensus
Authors: Davies Larissa , Jiménez Alfonso , Nieto Inés , Mayo Xian , Reece Lindsay 
Published: January 2025

ABSTRACT
There is growing demand from policy makers and practitioners to understand and measure the social impact of physical activity and sport (PAS) driven by the needs to justify investments from funders, improve decision-making of PAS managers, and produce robust and defensible evidence to underpin international and national PAS policy. Social return on investment (SROI) has emerged as a credible framework for measuring the non-financial impact of PAS; however, there is a lack of agreement about what and how social outcomes should be measured and valued. This article presents a research project that aims to address this gap through a systematic review and three-round Delphi study. The review identified five domains of social impact, and the Delphi study achieved consensus across 29 statements relating to health, education, crime, social capital, and well-being. The next stage of the project is to establish the most appropriate valuation techniques for capturing the monetary value of social outcomes from PAS across the domains. When complete, this research should encourage a more standardized approach to social impact measurement, which will help PAS stakeholders to articulate the social value of the sector more consistently.
The co-location of health care and leisure as part of a whole-system approach to physical activity promotion
Authors: Grinvalds Natalie , Shearn Katie , Humphreys Helen , Lowe Anna , De Vivo Marlize , Brown Beth , Copeland Robert J. 
Published: January 2025

ABSTRACT
Individual-level interventions are insufficient to create the enabling conditions for population-level shifts in physical activity. This is evidenced by a lack of progress tackling physical inactivity across the globe. A more integrative and holistic approach is needed that recognizes the different contexts within which physical activity takes place. The interactions that occur between individuals and wider policy, environmental, and structural factors are also worthy of attention. This article explores an attempt to apply systems thinking and co-design to a health care context. We argue that co-locating health care clinics within leisure facilities can make it easier for people, particularly those with a health condition, to engage in physical activity.
The Role of Physical Activity in Reducing Inflammation: Implications for Preventive Medicine
Authors: Kmieć Justyna Weronika , Kulej Piotr , Woźniak Justyna , Biesiada Wiktor , Chernysh Anna-Mariia , Dusińska Aleksandra , Waszczyński Jakub , Fuczyło Kamila , Stankevič Karolina 
Published: January 2025

Physical activity is an accessible and free, modifiable factor which influences our health and wellbeing. Increased physical activity (PA) and exercise are associated with reduced chronic disease risk. The prevalence of physical inactivity is constantly increasing. Physical inactivity is associated with the development of various chronic diseases including cancer, cardiovascular, metabolic and neurodegenerative diseases [1].
All countries should adopt policies focused on encouraging people to move at all stages of life.
Understanding the links that exist between PA and inflammation can bring new vision on common chronic disease. There is no doubt it would favorably impact global society on the economic as well as productivity side. This review highlights anti-inflammatory effects of PA and exercise training in selected, frequent illnesses our time.
Purpose of the work: The purpose of this review is to explore and synthesize current scientific evidence on the anti-inflammatory effects of PA and exercise training, focusing on their impact on the prevention and management of chronic diseases.
Materials and Methods: We conducted a literature search on the MEDLINE database in October 2024, utilizing keywords including 'physical activity', 'inflammation', ‘exercise’ and 'exerkine' to identify pertinent documents. The inclusion criterion was that the article addresses the following issues: the relationship between PA and inflammation in chronic diseases, the biochemical mechanisms linking physical activity to anti-inflammatory effects. Non-English language, or without full-text available articles, and publications not addressing the issues described in the inclusion criteria and were excluded from the analysis.
Congenital cytomegalovirus - current state of knowledge on the treatment and prevention of fetuses and newborns
Authors: Grego Katarzyna , Grego Mateusz , Stojak Łukasz , Popiela Dariusz , Urbańska Karina , Kwiatkowski Filip , Baczewski Mateusz , Czyż Witold 
Published: January 2025

Cytomegalovirus (CMV) is common pathogen in the human population and one of the most causes of intrauterine infections of the fetus. It is a component of the acronym TORCH describing pathogens which are a significant risk factor for miscarrings or serious damage to the fetus. Symptomatic congenital cytomegalovirus occurs in about 10% of infected newborns and, among of the other things, can cause hearing loosing, vision impairment or cognitive impairment in the children. Importantly, a child who is asymptomatic at the time of delivery is still at risk of developing dysfunctions in the future. Currently there is no effective vaccine against cytomegalovirus. There are attempts to treat pregnant women with antiviral drugs and hyperimmunoglobulins. The treatment is intended to protect the fetus from vertical transmission of the virus or to reduce the effects of infection. An important aspect is the time of starting treatment for the woman and the seroprevalence of expectant mothers. The risk of fetal infection increases with the age of pregnancy. Primary infection of the mother poses a greater danger to the fetus than secondary infection. The key moment of treatment apear to be the first trimester of pregnancy, because it is during this period that the greatest devastation occurs in the rapidly developing fetus. For this reason, the greatest benefit from treatment may be obtained by pregnant women with primary CMV infection in the first trimester of pregnancy. In this article, we will present the problem of congenital cytomegalovirus and describe the current proposals for treatment and prophylaxis used in fetuses and newborns infected with cytomegalovirus, we will present the current state of knowledge about potential side effects of its use.
Designing the Liner Shipping Network of Tomorrow Powered by Alternative Fuels
Authors: Johansen Mikkel Lassen , Holst Klaus Kähler , Ropke Stefan 
Published: January 2025

The liner shipping industry is undergoing an extensive decarbonization process to reduce its 275 million tons of CO2 emissions as of 2018. In this process, the long-term solution is the introduction of new alternative maritime fuels. The introduction of alternative fuels presents a great set of unknowns. Among these are the strategic concerns regarding sourcing of alternative fuels and, operationally, how the new fuels might affect the network of shipping routes. We propose a problem formulation that integrates fuel supply/demand into the liner shipping network design problem. Here, we present a model to determine the production sites and distribution of new alternative fuels—we consider methanol and ammonia. For the network design problem, we apply an adaptive large neighborhood search combined with a delayed column generation process. In addition, we wish to test the effect of designing a robust network under uncertain demand conditions because of the problem’s strategic nature and importance. Therefore, our proposed solution method will have a deterministic and stochastic setup when we apply it to the second-largest multihub instance, WorldSmall, known from LINER-LIB. In the deterministic setting, our proposed solution method finds a new best solution to three instances from LINER-LIB. For the main considered WorldSmall instance, we even noticed a new best solution in all our tested fuel settings. In addition, we note a profit drop of 7.2% between a bunker-powered and pure alternative fuel–powered network. The selected alternative fuel production sites favor a proximity to European ports and have a heavy reliance on wind turbines. The stochastic results clearly showed that the found networks were much more resilient to the demand changes. Neglecting the perspective of uncertain demand leads to highly fluctuating profits. Supplemental Material: The online appendix is available at https://doi.org/10.1287/trsc.2023.0143 .
A new STI in the city: MPOX in Barcelona. First outbreak (5/2022-5/2023) and subsequent resurgence
Authors: Palma David , Guillaumes Montserrat , Pericas Carles , de Andrés Anna , Prieto Raquel , Álvarez-Bruned Laia , Ospina Jesús , Santiá Paula , García de Olalla Patricia , Rius Cristina 
Published: January 2025

Background
In May 2022, after the suspension of the mobility restrictions due to the COVID-19 pandemic, the first outbreak of MPOX virus, transmitted from human to human, was detected outside of Africa, affecting mostly sexually active men who have sex with men. Our aim is to report the first outbreak of MPOX in Barcelona city in the period from 5/2022 to 5/2023 and the subsequent surge of cases in 8/2023.

Methods
We performed a descriptive study of all notified cases in city residents, obtained through epidemiological surveys. The analyses are presented for the hospitalized cases and the key population of men who have sex with men.

Results
Of 2037 notified cases, 82.6% were confirmed. The cumulative incidence in the general population was 1.03 (95%CI 1.00–1.06) per 1000 inhabitants and 2.13 (2.01–2.17) per 1000 in men. Men were older than women, with a median age of 37 years (interquartile range 31–43). While 84.5% of men reported having sex with partners of the same gender, 70.9% of women only reported sex with partners of the opposite gender. Complications occurred in 4.1% of infected persons, 1.6% required hospitalization, and no deaths were registered. Georeferencing was highly associated with gay venues. Gay, bisexual and other men who have sex with men (GBMSM) accounted for most cases and severe cases, and were associated with attending public sex venues and not providing contact tracing information. Digital and printed prevention campaign materials were developed for GBMSM.

Discussion
The 2022 MPOX outbreak posed a major challenge to surveillance and sexual health services worldwide. With new cases and re-infections on the rise, MPOX may become a regular infection to be incorporated in STI testing and management guidelines. Barcelona has some characteristics that may facilitate the occurrence and spread of emergencies related to sexual health.