bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gut Microbiota Signatures Are Associated With Psychopathological Profiles in Patients With Ulcerative Colitis: Results From an Italian Tertiary IBD Center
Authors: Scaldaferri Franco , D’Onofrio Antonio Maria , Calia Rosaria , Di Vincenzo Federica , Ferrajoli Gaspare Filippo , Petito Valentina , Maggio Eleonora , Pafundi Pia Clara , Napolitano Daniele , Masi Letizia , Schiavoni Elisa , Fanali Caterina , Puca Pierluigi , Turchini Laura , Lopetuso Loris Riccardo , Del Chierico Federica , Putignani Lorenza , Gasbarrini Antonio , Camardese and Giovanni 
Published: June 2023

Abstract

Background
Several patients with ulcerative colitis (UC) suffer from psychiatric disorders, such as major depressive disorder, anxiety, or bipolar disorder, and show specific personality traits. Despite this, there are few data about personality profiles’ characterization in UC patients and about correlation of their psychopathological profile with their intestinal microbiota.
The aim of our study is to analyze the psychopathological and personality profile of UC patients and correlate it with specific signatures of their gut microbiota.

Methods
This is a prospective interventional longitudinal cohort study. We enrolled consecutive patients affected by UC attending to the IBD Unit of Center for Digestive Disease of “A. Gemelli” IRCCS Hospital in Rome and a group of healthy subjects, matched for specific characteristics. Each patient was evaluated by a gastroenterologist and a psychiatrist. Moreover, all participants underwent psychological tests and a collection of stool samples.

Results
We recruited 39 UC patients and 37 healthy subjects. Most patients showed high level of alexithymia, anxiety symptoms, depressive symptoms, as well as neuroticism and hypochondria, with obsessive-compulsive features at the behavioral level, which significantly impaired their quality of life and abilities at work. Gut microbiota analysis in UC patients demonstrated an increase in actinobacteria, Proteobacteria and Saccharibacteria (TM7), with a reduction in verrucomicrobia, euryarchaeota and tenericutes.

Conclusions
Our study confirmed the presence of high levels of psycho-emotional distress in UC patients, alongside alterations of the intestinal microbiota, and highlighted some families and genera of bacteria (Enterobacteriaceae, Streptococcus, Veillonella, Klebsiella, and Clostridiaceae) as potential markers of an altered gut-brain axis in these patients.
Inflammatory Bowel Disease in Appalachian Kentucky: An Investigation of Outcomes and Health Care Utilization
Authors: Rhudy Christian N , Perry Courtney L , Hawk Gregory S , Flomenhoft Deborah R , Talbert Jeffery C , Barrett Terrence A 
Published: June 2023

Abstract

Background
Rural residence has been associated with a lower incidence of inflammatory bowel disease (IBD) but higher health care utilization and worse outcomes. Socioeconomic status is intrinsically tied to both IBD incidence and outcomes. Inflammatory bowel disease outcomes have not been investigated in Appalachia: a rural, economically distressed region rife with risk factors for both increased incidence and unfavorable outcomes.

Methods
Hospital inpatient discharge and outpatient services databases were utilized to assess outcomes in patients diagnosed with either Crohn’s disease (CD) or ulcerative colitis (UC) in Kentucky. Encounters were classified by patient residence in Appalachian or non-Appalachian counties. Data were reported as crude and age-adjusted rates of visits per 100,000 population per year collected in 2016 to 2019. National inpatient discharge data from 2019, stratified by rural and urban classification codes, were utilized to compare Kentucky to national trends.

Results
Crude and age-adjusted rates of inpatient, emergency department and outpatient encounters were higher in the Appalachian cohort for all 4 years observed. Appalachian inpatient encounters are more frequently associated with a surgical procedure (Appalachian, 676, 24.7% vs non-Appalachian, 1408, 22.2%; P = .0091). In 2019, the Kentucky Appalachian cohort had significantly higher crude and age-adjusted rates of inpatient discharges for all IBD diagnoses compared with national rural and nonrural populations (crude 55.2; 95% CI, 50.9-59.5; age-adjusted 56.7; 95% CI, 52.1-61.3).

Conclusions
There is disproportionately higher IBD health care utilization in Appalachian Kentucky compared with all cohorts, including the national rural population. There is a need for aggressive investigation into root causes of these disparate outcomes and identification of barriers to appropriate IBD care.
Probing the Phycosphere: Techniques to Study Bacteria-Phytoplankton Interactions
Authors: Platt Amanda J , Whalen Kristen E 
Published: June 2023

Synopsis
The cumulative outcome of bacteria-phytoplankton cell-cell interactions has global-scale consequences that necessitate a more comprehensive understanding of the species that form these relationships, the chemical exchanges that govern them, and the chemical cues that trigger them. However, the diffuse liquid environment supporting these exchanges is inherently difficult to interrogate, which has moved researchers to combine multi-omics analyses, genome mining tools, genetic probes, and mathematical models to gain insight into the species and chemical networks existing around individual phytoplankton cells. Yet, fundamental questions still remain about these micro-scale interactions, creating an opportunity for innovating new methods where biology and chemistry interface with engineering and mathematics.
The mining sector: profit-seeking strategies, innovation patterns, and commodity prices
Authors: Calzada Olvera Beatriz , Iizuka Michiko 
Published: June 2023

Abstract
Innovation in the mining sector is crucial for industrial, economic, and sustainable development, particularly for developing economies. It is important to understand the factors that stimulate innovation in this sector to upgrade productivity and growth. In the mining sector, innovation is driven by profit structure, which in turn depends strongly on commodity prices. We hypothesize two innovation responses to prices, which we test against existing evidence found in recent literature and available industry data. We find two different innovation responses to prices: exploration and in-house research and development (R&D) investments by mining companies increase as commodity prices rise, while the use of suppliers’ innovation intensifies when prices decrease. Policies to strengthen the sector should provide long-term support for the Mining Equipment, Technology and Services (METS) sector so that they can continuously invest in R&D to provide innovative solutions for mining firms, possibly extending to lateral linkages, applying digital and low-carbon solutions developed for the mining sector and beyond.
Venous concerns after lingula sparing left upper lobectomy
Authors: Lafouasse Chloé , Gossot Dominique , Seguin-Givelet Agathe 
Published: June 2023

Abstract
Postoperative ischaemia of the lingula is a complication of left upper lobe trisegmentectomy, usually attributed to a twist of the remaining lingula. It can also be related to other factors such as venous interruption. We report 3 cases of reoperation after lingula-sparing left upper lobectomy for suspected ischaemia. None were related to torsion. Accidental injury of the lingular venous drainage or abnormal venous pattern can be the leading cause of these ischaemia.
Upstaged from cT1a-c to pT2a lung cancer, related to visceral pleural invasion patients, after segmentectomy: is it an indication to complete resection to lobectomy?
Authors: Lula Lukadi Joseph , Mariolo Alessio Vincenzo , Ozgur Emrah Gokay , Gossot Dominique , Baste Jean-Marc , De Latour Bertrand , Seguin-Givelet Agathe 
Published: June 2023

Abstract

OBJECTIVES
Segmentectomy may be indicated for T1a-cN0 non-small-cell lung cancer. However, several patients are upstaged pT2a at final pathological examination due to visceral pleural invasion (VPI). As resection is usually not completed to lobectomy, this may raise issue of potential worse prognosis. The aim of this study is to compare prognosis of VPI upstaged cT1N0 patients operated on by segmentectomy or lobectomy.

METHODS
Data of patients from 3 centres were analysed. This was a retrospective study, of patients operated on from April 2007 to December 2019. Survival and recurrence were assessed by Kaplan–Meier method and cox regression analysis.

RESULTS
Lobectomy and segmentectomy were performed in 191 (75.4%) and in 62 (24.5%) patients, respectively. No difference in 5-year disease-free survival rate between lobectomy (70%) and segmentectomy (64.7%) was observed. There was no difference in loco-regional recurrence, nor in ipsilateral pleural recurrence. The distant recurrence rate was higher (P = 0.027) in the segmentectomy group. Five-year overall survival rate was similar for both lobectomy (73%) and segmentectomy (75.8%) groups. After propensity score matching, there was no difference in 5-year disease-free survival rate (P = 0.27) between lobectomy (85%) and segmentectomy (66.9%), and in 5-year overall survival rate (P = 0.42) between the 2 groups (lobectomy 76.3% vs segmentectomy 80.1%). Segmentectomy was not impacting neither recurrence, nor survival.

CONCLUSIONS
Detection of VPI (pT2a upstage) in patients who underwent segmentectomy for cT1a-c non-small-cell lung cancer does not seem to be an indication to extend resection to lobectomy.
A dynamical model of TGF-β activation in asthmatic airways
Authors: Pybus Hannah J , O’Dea Reuben D , Brook Bindi S 
Published: June 2023

Abstract
Excessive activation of the regulatory cytokine transforming growth factor $\beta $ (TGF-$\beta $) via contraction of airway smooth muscle (ASM) is associated with the development of asthma. In this study, we develop an ordinary differential equation model that describes the change in density of the key airway wall constituents, ASM and extracellular matrix (ECM), and their interplay with subcellular signalling pathways leading to the activation of TGF-$\beta $. We identify bistable parameter regimes where there are two positive steady states, corresponding to either reduced or elevated TGF-$\beta $ concentration, with the latter leading additionally to increased ASM and ECM density. We associate the former with a healthy homeostatic state and the latter with a diseased (asthmatic) state. We demonstrate that external stimuli, inducing TGF-$\beta $ activation via ASM contraction (mimicking an asthmatic exacerbation), can perturb the system irreversibly from the healthy state to the diseased one. We show that the properties of the stimuli, such as their frequency or strength, and the clearance of surplus active TGF-$\beta $, are important in determining the long-term dynamics and the development of disease. Finally, we demonstrate the utility of this model in investigating temporal responses to bronchial thermoplasty, a therapeutic intervention in which ASM is ablated by applying thermal energy to the airway wall. The model predicts the parameter-dependent threshold damage required to obtain irreversible reduction in ASM content, suggesting that certain asthma phenotypes are more likely to benefit from this intervention.
Management of children with danger signs in integrated community case management care in rural southwestern Uganda (2014–2018)
Authors: Matte Michael , Ntaro Moses , Kenney Jessica , Patel Palka , Wesuta Andrew Christopher , Kawungezi Peter Chris , Bwambale Shem , Ayebare David , Baguma Stephen , Bagenda Fred , Miller James S , Stone Geren , Mulogo Edgar Mugema 
Published: June 2023

Abstract

Background
In integrated community case management (iCCM) care, community health workers (CHWs) provide home-based management of fever, diarrhea and fast breathing for children aged &lt;5 y. The iCCM protocol recommends that children with danger signs for severe illness are referred by CHWs to health facilities within their catchment area. This study examines the management of danger signs by CHWs implementing iCCM in a rural context.

Methods
A retrospective observational study that examined clinical records for all patients with danger signs evaluated by CHWs from March 2014 to December 2018 was conducted.

Results
In total, 229 children aged &lt;5 y had been recorded as having a danger sign during 2014–2018. Of these children, 56% were males with a mean age of 25 (SD 16.9) mo, among whom 78% were referred by the CHWs as per the iCCM protocol. The age category of 12 to 35 mo had the highest numbers of prereferred and referred cases (54% and 46%, respectively).

Conclusions
CHWs play a key role in early symptomatic detection, prereferral treatment and early referral of children aged &lt;5 y. Danger signs among children aged &lt;5 y, if left untreated, can result in death. A high proportion of the children with danger signs were referred as per the iCCM protocol. Continuous CHW training is emphasized to reduce the number of referral cases that are missed. More studies need to focus on children aged 12–35 mo and why they are the most referred category. Policymakers should occasionally revise iCCM guidelines to detail the types of danger signs and how CHWs can address these.
Graffiti Writing as Creative Activism: Getting Up, Sheeplike Subversion, and Everyday Resistance
Authors: Baldini Andrea L 
Published: June 2023

Abstract
Is graffiti writing creative activism? In this paper, I challenge commonly held beliefs that graffiti writing is politically inert. On the contrary, I argue that graffiti writing is an example of creative activism. Rather than being a narcissistic form of vandalism, primarily directed at increasing one’s fame in front of an esoteric group, that is, fellow writers, writing is a form of everyday resistance allowing its practitioners to challenge authoritarian power. In questioning dominant hierarchies, graffiti is a powerful tool to help correct a specific instance of spatial injustice: the unequal distribution of access to urban surfaces for self-expression in the city, where corporations and political elites hold an unjustified monopoly over visual communication.
Genetic diversity and breed identification of Chinese and Vietnamese local chicken breeds based on microsatellite analysis
Authors: Zhuang Zhong , Zhao Long , Zong Weicheng , Guo Qixin , Li Xiaofan , Bi Yulin , Wang Zixiu , Jiang Yong , Chen Guohong , Li Bichun , Chang Guobin , Bai Hao 
Published: June 2023

AbstractSouth Asia and Southeast Asia are the origins of domestic chickens and are rich in poultry genetic resources, resulting in many unique local chicken breeds. However, with the rapid intensification of poultry farming worldwide, many local chicken breeds are threatened with extinction. In response to China’s “One Belt, One Road” policy, it is imperative to strengthen the conservation and breeding of local chicken breeds in China and Vietnam. This study characterized 18 microsatellite molecular genetic markers to analyze the genetic diversity of 21 local chicken populations in southern China (Yunnan and Guangxi Provinces) and Vietnam, breed identification tags for microsatellite loci were constructed. The results showed that a total of 377 alleles were detected in all breeds, and the most alleles (44) and the highest polymorphic information content (0.7820) were detected at the LEI0094 locus. The average polymorphic information content (PIC) content of the whole population was 0.65, indicating moderate polymorphism. The genetic diversity of the whole population was rich, except for two loci MCW0111 and MCW0016, that showed heterozygote excess at microsatellite loci, and the population had high genetic differentiation. The Vietnamese breeds showed low pairwise fixation coefficient (FST) and Nei’s standard genetic distance (DS) between them. According to the neighbor-joining dendrogram constructed by DS and the analysis of population genetic structure using the structure program, Longshengfeng chicken, Yunlong dwarf chicken, Tengchong white chicken, Xiayan chicken, and Daweishan mini chicken are similar, and Xishuangbanna game fowl, Wuding chicken, and Lanping silky chicken are similar to Yanjin black-bone chicken. In addition, excluding Dongtao chicken, other Vietnamese breeds are clustered together, indicating that the southern chicken breeds are closely related and have experienced better breeding. Overall, the whole population is rich in genetic resources, and the chicken breeds in the three regions are genetically close because of geographical factors and human activities. Dongtao chicken in Vietnamese, Chinese Yunnan local chicken breeds (Gallus gallus spadiceus), and red jungle fowl chickens (Gallus gallus) may have the same origin. We also constructed unique microsatellite molecular markers for 20 cultivars using 15 microsatellite loci. This study provides valuable insights to facilitate breed identification, improve cultivar protection, and new germplasm construction.
Insights into the toxicity, biochemical activity, and molecular docking of Cymbopogon citratus essential oils and citral on Spodoptera littoralis (Lepidoptera: Noctuidae)
Authors: Moustafa Moataz A M , Hassan Nancy N , Alfuhaid Nawal Abdulaziz , Amer Alia , Awad Mona 
Published: June 2023

Abstract
Insecticide resistance is a significant problem in insect management that can result from several processes including target-site change and increased activity of detoxifying enzymes. Spodoptera littoralis is one of the most resistant insect pests. For more effective insect management, alternatives to synthetic pesticides are encouraged. One of these alternatives is essential oils (EOs). Cymbopogon citratus EO and its main constituent citral were, therefore, considered in this study. The results revealed that C. citratus EO and citral exhibited significant larvicidal activity against S. littoralis, and the former was insignificantly more toxic than the latter. Additionally, treatments significantly affected the activity of detoxification enzymes. Cytochrome P-450 and glutathione-S-transferase were inhibited, while carboxylesterases, a-esterase and β-esterase, were induced. The molecular docking study indicated that citral bonded with the amino acids cysteine (CYS 345) and histidine (HIS 343) of cytochrome P-450. This result suggests that interaction with cytochrome P-450 enzyme is one key mechanism by which C. citratus EO and citral act in S. littoralis. The results of our study are hoped to contribute to a better understanding of the mechanism of action of essential oils at the biochemical and molecular levels and provide safer and more efficient pest management solutions for S. littoralis.
Surgical treatment of snapping proximal hamstring tendon syndrome: the resolution of snapping and excellent patient satisfaction
Authors: Mitchell Cecilia V , Lamba Abhinav , Okoroha Kelechi R , Economopoulos Kostas J , Spinner Robert J , Krych Aaron J 
Published: June 2023

ABSTRACT
Snapping proximal hamstring is an uncommon phenomenon, with few case reports documenting surgical treatment. The purpose of this study is to report snapping resolution, minimum 2-year post-operative patient-reported outcome (PRO), satisfaction scores and complications from patients who underwent surgical release of the conjoint tendon from the sacrotuberous ligament with reattachment to the ischial tuberosity. Prospectively collected data from two institutional databases were retrospectively reviewed for patients who underwent hamstring repair for partial- or full-thickness tears. Patients were included if they demonstrated ‘snapping proximal hamstrings’ on preoperative physical examination, including ultrasound confirmation, and repair subsequently performed. Patients were excluded if they had reconstruction of the proximal hamstring tendon or claimed worker’s compensation. With a total of 20 patients (15 females and 5 males), successful resolution of snapping was reported in 100% of the cohort. For patients with pre- and post-surgical lower-extremity functional scores (LEFS), post-surgical LEFS were significantly higher than pre-surgical LEFS (pre-surgical: 17.0 ± 4.0, post-surgical: 73.6 ± 3.3, P &lt; 0.001). Average post-operative PROs were as follows: International Hip Outcome Tool-12, 92.3 ± 8.3; modified Harris Hip Score, 93.2 ± 7.8; Non-arthritic Hip Score, 92.5 ± 6.8; Hip Outcome Score-Sports Specific Subscale, 94.4 ± 6.7; LEFS, 73.9 ± 3.4; and median visual analog scale of 0 with an interquartile range of 0-1. Patient satisfaction was ‘very satisfied’ in 19 (95%) patients and ‘satisfied’ in 1 (5%) patient. At a minimum 2-year follow-up, patients who underwent surgical treatment for chronic snapping of the proximal hamstrings demonstrated complete resolution of painful posterior snapping, reported high PROs and satisfaction, and had no reported post-operative complications.
Last year’s model? Investment arbitration, negotiation, and the gap between Model BITs and IIAs
Authors: Haftel Yoram Z , Link Morr , Broude Tomer 
Published: June 2023

ABSTRACT
With more than 3000 international investment agreements (IIAs) worldwide, states negotiate similar agreements multiple times with numerous partners. Accordingly, many states have developed template agreements known as ‘Model bilateral investment treaties (BITs)’. Nevertheless, concluded IIAs commonly deviate from the corresponding Model BITs, albeit to varying degrees. Investigating this variation, we examine the impact of Model Countries and their Partner Countries’ investor–state dispute settlement (ISDS) experience. Specifically, we argue that the Model Country adopts changes sought by the Partner Country during the negotiation process in order to accommodate the latter’s preferences, which were shaped by lessons learned from ISDS cases. Empirically, we introduce novel measures of divergence between Model BITs and IIAs, based on the concept and scheme of state regulatory space, with respect to several key aspects of investment rules. Coding a large number of Model BITs and IIAs on these variables and controlling for a host of alternative explanations, we find that the higher number of investment claims filed against the Partner Country, but not the Model Country, is associated with greater divergence between the Model Country’s Model BITs and its IIAs. This effect is especially noticeable with respect to important substantive investment rules.
Latest classification of ependymoma in the molecular era and advances in its treatment: a review
Authors: Yamaguchi Junya , Ohka Fumiharu , Motomura Kazuya , Saito Ryuta 
Published: June 2023

AbstractEpendymoma is a rare central nervous system (CNS) tumour occurring in all age groups and is one of the most common paediatric malignant brain tumours. Unlike other malignant brain tumours, ependymomas have few identified point mutations and genetic and epigenetic features. With advances in molecular understanding, the latest 2021 World Health Organization (WHO) classification of CNS tumours divided ependymomas into 10 diagnostic categories based on the histology, molecular information and location; this accurately reflected the prognosis and biology of this tumour. Although maximal surgical resection followed by radiotherapy is considered the standard treatment method, and chemotherapy is considered ineffective, the validation of the role of these treatment modalities continues. Although the rarity and long-term clinical course of ependymoma make designing and conducting prospective clinical trials challenging, knowledge is steadily accumulating and progress is being made. Much of the clinical knowledge obtained from clinical trials to date was based on the previous histology-based WHO classifications, and the addition of new molecular information may lead to more complex treatment strategies. Therefore, this review presents the latest findings on the molecular classification of ependymomas and advances in its treatment.