bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of Blockchain technology as a moderator on the relationship between big data and the risk of financial disclosure (analytical study in the Egyptian and Iraqi stock exchange)
Authors: Abdel Sabour Khaled , Al-Waeli Abbas 
Published: March 2023

This paper aims to explain the impact of Blockchain Technology as a moderator in the relationship between Big Data and The Risk of Financial Disclosure to address the Risk of Financial Disclosure. Therefore, this technique was used to reduce the risks of disclosing financial and accounting data for various companies. The estimated population size of accounting information systems and information technology professionals is more than 300 in the Egyptian and Iraqi Stock Exchange. The results indicate that all the direct hypotheses that reflect the relation between Big Data characteristics and FDR are supported which is less than 0.05. There is no impact of Volume on Financial Disclosure Risk with a p-value=0.074. the indirect effect of Blockchain Technology on the relationship between (VEL, VER and VOL) and Financial Disclosure Risk was significant with a p-value of 0.048,0.024,0.001 respectively, which is less than 0.05 and does not support the relationship between VAR and Financial Disclosure Risk a p-value of 0.735. Then, we recommend state-of-the-art studies on the use of blockchain for big data applications in different vertical domains such as smart cities, Financial transactions, smart transportation, and smart bank accounts. For a better understanding, some representative blockchain-big data projects are also presented and analysed. Finally, challenges and future directions are discussed to further drive research in the countries of the Middle East. This paper presents the novel solutions associated with Big Data with Financial Disclosure Risks that can be addressed by Blockchain technology. As Well as present the motivations behind the use of blockchain for big data. We show that blockchain has great potential for facilitating big data analytics such as control of dirty data, enhanced security and transparency, enhanced quality of data, the management of data sharing and, Addressing risk financial disclosure
The use of technologies for stabilizing the electrophysical characteristics of sensor structures used in the development and manufacture of measuring transducers
Authors: Kabdoldina Assem , Ualiyev Zhomart , Ibrayev Sayat , Jamalov Nutpulla , Ibrayeva Arman , Tuleshov Yerkebulan , Analiyeva Azhar , Arinova Dinara , Khikmetov Askar , Uaissov Bolat 
Published: March 2023

The object of the study is the design, manufacturing technology and methods of stabilizing the electrophysical characteristics of measuring transducers. The problem solved in the research is the creation of methods and design and technological solutions to ensure stability used in the development and manufacture of measuring transducers. As a result of the conducted research, designs and technologies for manufacturing and stabilizing the electrophysical characteristics of measuring transducers were developed. The features of the developed designs of measuring transducers are increased in comparison with the known time stability with a basic error of no more than 0.1 %/year. Technologies for stabilizing the parameters of measuring transducers, in contrast to the known ones, differ in their versatility, since most elastic elements that perceive mechanical magnitude are membranes and beams, on which thermocompensating films are easily applied. The stabilization of the parameters of the entire measuring transducer, unlike the known ones, is carried out after the removal of internal mechanical stresses of each element and part of the measuring transducer through the integrated use of current and vibration dynamic loads. Thus, the use of complex compensation due to the application of a new method of compensation of internal mechanical stresses in the structure, based on the use of multilayer film compositions formed on sensitive elements, followed by thermal and vibration stabilization of measuring transducers. In addition, reducing the measurement error and increasing the time and parametric stability of the measuring transducers is achieved through the use of specialized heat treatment modes, training resonant vibration and current loads. When developing structures and stabilization methods, previously developed engineering mathematical models were used, including constructive, informational, dimensional, technological and circuit engineering. At the same time, depending on the adopted design and the technology used, engineering models were modified by including known coefficients and dependencies. This method has significantly reduced the cost and complexity of development
METHOD AND SOFTWARE COMPONENT MODEL FOR SKIN DISEASE DIAGNOSIS
Authors: Lovkin V. M. , Subbotin S. A. , Oliinyk A. O. , Myronenko N. V. 
Published: March 2023

Context. The problem of skin disease diagnosis was investigated in the paper. Its actuality is caused by the necessity of automation of at least advisory medical decision making. Such decisions are made in telemedicine, for instance, when skin disease diagnostics is performed under specific conditions. These conditions are specified by situations when data for analysis are collected but a qualified doctor has no possibility to process the data and to make a diagnosis decision based on it. The object of the study is a process of skin disease diagnosis.
Objective. The objective of the study is to develop a skin disease diagnosis method to automate making of advisory medical diagnosis decisions and to increase efficiency of such decisions.
Method. The skin disease diagnosis method was proposed in the work. This method applies the modified ResNet50 model. It was proposed to add layers to the ResNet50 model and to train it using transfer learning and fine-tuning techniques. The method also defines image processing in particular through the change of its resolution and uses oversampling technique to prepare a dataset for model training.
Results. Experimental investigation of the proposed method was performed using the HAM10000 dataset which contains images of skin diseases. The images were collected using dermatoscopy method. The dataset contains observations for 7 different skin diseases. The proposed method is characterized by the accuracy of 96.31% on this dataset. It is improved accuracy in comparison with the existing neural network models. Software component model was created to give a possibility to integrate the proposed method into a medical diagnosis system.
Conclusions. The obtained results of the investigation suggest application of the proposed skin disease method in medical diagnostic system to make advisory decisions by the system and to support making final decisions by a doctor.
PARAMETER-DRIVEN GENERATION OF EVALUATION PROGRAM FOR A NEUROEVOLUTION ALGORITHM ON A BINARY MULTIPLEXER EXAMPLE
Authors: Doroshenko A. Yu. , Achour I. Z. , Yatsenko O. A. 
Published: March 2023

Context. The problem of automated development of evaluation programs for the neuroevolution of augmenting topologies. Neuroevolution algorithms apply mechanisms of mutation, recombination, and selection to find neural networks with behavior that satisfies the conditions of a certain formally defined problem. An example of such a problem is finding a neural network that implements a certain digital logic.
Objective. The goal of the work is the automated design and generation of an evaluation program for a sample neuroevolution problem (binary multiplexer).
Method. The methods and tools of Glushkov’s algebra of algorithms and hyperscheme algebra are applied for the parameterdriven generation of a neuroevolution evaluation program for a binary multiplexer. Glushkov’s algebra is the basis of the algorithmic language intended for multilevel structural design and documentation of sequential and parallel algorithms and programs in a form close to a natural language. Hyperschemes are high-level parameterized specifications intended for solving a certain class of problems. Setting parameter values and subsequent interpretation of hyperschemes allows obtaining algorithms adapted to specific conditions of their use.
Results. The facilities of hyperschemes were implemented in the developed integrated toolkit for the automated design and synthesis of programs. Based on algorithm schemes, the system generates programs in a target programming language. The advantage of the system is the possibility of describing algorithm schemes in a natural-linguistic form. An experiment was conducted consisting in the execution of the generated program for the problem of evaluating a binary multiplexer on a distributed cloud platform. The multiplexer example is included in SharpNEAT, an open-source framework that implements the genetic neuroevolution algorithm NEAT for the .NET platform. The parallel distributed implementation of the SharpNEAT was proposed in the previous work of the authors.
Conclusions. The conducted experiments demonstrated the possibility of the developed distributed system to perform evaluations on 64 cloud clients-executors and obtain an increase in 60–100% of the maximum capabilities of a single-processor local implementation.
La importancia de la Educación Física en contextos de inclusión de personas con discapacidad
Authors: Mendoza Muñoz Ricardo Alonso 
Published: March 2023

Hoy en día, en el ámbito educativo, se escuchan de manera recurrente términos como inclusión, diversidad, discapacidad, accesibilidad, estrategias de enseñanza-aprendizaje, entre otros. Durante la última década los gobiernos y el sistema educativo nacional han hecho notables esfuerzos para lograr una mejor atención educativa con criterios de equidad, igualdad y participación, que permitan a personas con discapacidad o necesidades educativas especiales disfrutar de una educación más adaptada a sus capacidades, sin ser excluidas y/o segregadas.
En este proceso, las Instituciones de Educación Superior [IES], entre ellas las universidades, juegan un rol muy importante, ya que son los lugares donde se forman ética y académicamente los profesionales del campo de la educación y que más adelante van a desempeñarse como docentes en diferentes niveles como en primaria, secundaria e incluso la misma educación superior, siendo determinantes a través de su labor para lograr un verdadero y favorable proceso educativo desde el área del saber o formación que les corresponda orientar.
Lo que se pretende por medio de este artículo es resaltar la importancia que tiene dentro de la formación profesional del Licenciado en Educación Física de la Universidad CESMAG, la realización de prácticas pedagógicas en población con discapacidad, con el fn de sensibilizar y lograr que se conviertan en agentes que favorezcan la inclusión en los contextos donde se desenvuelvan.
Lo que se pretende por medio de este artículo es resaltar la importancia de incluir las prácticas pedagógicas en población con discapacidad dentro de la formación profesional del Licenciado en Educación Física de la Universidad CESMAG, con el fin de sensibilizar y lograr que se convierta en agente que favorezca la inclusión en los contextos donde se desenvuelva.
ÖNEMİ BELİRSİZ ATİPİLİ HASTALARDAKİ POSTOPERATİF HİSTOPATOLOJİK MALİGNİTE VARLIĞI
Authors: BAŞÇEKEN Salim İlksen , TİKİCİ Deniz 
Published: March 2023

Amaç
Tiroid kanseri en sık görülen endokrin malignitesidir
ve klinik görünümü nodüllerle karakterizedir. Tiroid
patolojileri için yapılan biyopsilerde ‘Önemi belirsiz
atipi’ (ÖBA) literatürdeki farklı malignite oranları nedeniyle
klinisyenler için önemli bir endişe kaynağıdır. Bu
çalışmada, AUS tanısı alan ve tiroid cerrahisi geçiren
hastalarda malignite oranlarını güncel literatür ışığında
sunmayı amaçladık.
Gereç ve Yöntem
2016-2021 yılları arasında kliniğimizde ince iğne aspirasyon
biyopsisinde (İİAB) ÖBA tanısı alan ve tiroid
cerrahisi uygulanan 174 hastanın demografik ve histopatolojik
verileri retrospektif olarak analiz edildi. Hastalar
histopatolojik özelliklerine göre malign ve benign
olarak iki gruba ayrıldı. Gruplar arasındaki istatistiksel
anlamlılık Ki-kare ve Student t-testleri kullanılarak belirlenmiştir.
P değeri 0.05).
Sonuç
Bethesda sınıflamasına göre ÖBA için malignite oranı
%15-30 olarak belirtilmiştir. Çalışmamızda malignite
oranı, ülkemizde yapılan benzer çalışmalara benzer
olarak, %43.5 saptanmıştır. ÖBA tanısıyla tiroid cerrahisi
planlanan vakalarda, yüksek malignite olasılığı
nedeniyle, lobektomiye alternatif olarak total tiroidektomi
de bir seçenek olarak düşünülmelidir.
Results of complex treatment of patients with locally advanced squamous cell carcinoma of the paranasal sinuses and nasal cavity using induction chemotherapy
Authors: Dеshkina T.   I. , Bolotina L.  V. , Gevorkov A.  R. , Boyko A.  V. , Kornietskaya A.  L. , Polyakov A. P. , Golubev P.   V. , Sydykova R.  S. , Fedenko A. A. 
Published: March 2023

Introduction. About 600 new cases of malignant neoplasms of the paranasal sinuses and nasal cavity are detected annually in Russia. To date, there are no randomized trials to determine the optimal treatment algorithm for this group of patients. Data on the use of induction chemotherapy in squamous cell carcinoma of sino-nasal tract are limited to a small series of clinical observations and, often, are retrospective in nature.Aim. Evaluation of the effectiveness of induction chemotherapy in patients with locally advanced squamous cell carcinoma of the paranasal sinuses and nasal cavity.Materials and methods. Since 2012, 22 patients with locally advanced cancer of the paranasal sinuses and nasal cavity have been treated in our center, who underwent 3-component induction chemotherapy according to the TPF protocol. Evaluation of the effectiveness of treatment was carried out according to the criteria of Response evaluation criteria in solid tumors 1.1 (RECIST 1.1). Patients with a decrease in the tumor size by 30 % or more, were followed by radiation therapy in doses of 66–70 Gy. Patients with a residual tumor underwent surgery after the end of chemoradiotherapy.Results. In 21 patients available for analysis, overall response rate after induction chemotherapy was 71 %: complete response was registered in 3 (14 %) patients, partial response in 12 (57 %), stable disease in 4 (19 %). Progression disease after 3 courses of induction chemotherapy was detected in 2 (10 %) patients.Conclusions. Thus, induction chemotherapy in patients with squamous cell carcinoma of sino-nasal tractseems to be a promising direction for investigation, that can significantly improve the long-term results of treatment of this category of patients and help to avoid of disabling surgery in some of them.
Results of treatment of patients with poorly differentiated carcinoma of the thyroid gland
Authors: Isaev P. A. , Polkin V. V. , Severskaya N. V. , Ilyin A. A. , Plugar A. K. , Ivanov S. A. , Kaprin A. D. 
Published: March 2023

Introduction. Poorly differentiated carcinoma of the thyroid gland (PDTC) is characterised by aggressive, high rate of tumor growth, massive infiltration, early lymphogenous and hematogenous dissemination. Ways to improve treatment outcomes include developing individual treatment programmes. Given the unsatisfactory results of the treatment, the search for combined treatment options is well founded.Materials and methods. An analysis was made of the treatment of PDTC in patients from May 2014 to July 2021. The study included 24 patients aged 22 to 81 years (9 (37.5 %) men and 15 (62.5 %) women). Surgical treatment was performed in 14 (58.3 %) cases. In 8 (33.3 %) cases, a course of radioiodine therapy with a total dose of 3–4 Gbq was performed in the postoperative period. Seven (29.2 %) patients underwent external beam radiation therapy. In 2 (8.3 %) cases, chemotherapy with carboplatin was performed simultaneously with external beam radiation therapy. Four (16.7 %) patients were prescribed lenvatinib. For one reason or another, 9 (37.5 %) patients did not receive treatment.Results. For patients not treated, the overall survival rate was 5.8 ± 0.5 months, for patients treated – 9.6 ± 1.0 months (p <0.00095). According to the index Lenvatinib showed a significant increase in the general group of patients – up to 15 months.Conclusion. Combined treatment in the form of a combination of surgical, radiation and chemotherapeutic methods at PDTC, allows to achieve much higher survival. In order to achieve longer-term stabilization, further research is needed on new ways to enhance the anti-tumor effect of modern drugs.
Comparison of transoral and combined approach for surgical treatment of moderately advanced tongue and floor of the mouth cancer
Authors: Karpenko A.   V. , Sibgatullin R.  R. , Boyko A.  A. , Nikolayeva O. M. 
Published: March 2023

Introduction. Surgical approach for oral cancer treatment is one of the key factors that determines oncologic effectiveness, risk of postoperative complications, need for reconstructive methods etc. Currently, there exists lack of strict criteria for using one or another approaches based on the sound scientific evidence for a primary tumor of given depth of invasion.Aim. The aim of the study is a retrospective comparative analysis of oncologic efficiency of transoral and combined approaches for surgical treatment of tongue and floor of the mouth moderately advanced carcinoma.Materials and methods. 75 patients aged between 30 and 80 years with tongue and floor of the mouth squamous cell carcinoma with depth of invasion from 10 to 20 mm were included into the study. In 29 cases the tumor was resected transorally (Group 1), in 45 – via combined approach (Group 2). Group 2 patients had more advanced tumors both locally and regionally. 13 patients of Group 1 and 27 patients of Group 2 underwent adjuvant radiotherapy. The following parameters were used for comparative analysis: the rate of local and regional recurrence, locoregional control, the rate of distant metastasis and Kaplan–Meyer overall survival.Results. Mean follow up was 33.77 ± 27.72 months (range 14–115 months). The rate of local and regional recurrence was higher in Group 2 (20 % vs 10.3 % and 22.2 % vs 17.2 % respectively). Locoregional control was better in Group 1 (72.4 % vs 62.2 %). The difference for neither of the above-mentioned parameters did not reach statistical significance. Median survival was statistically significantly better in Group 1: 66 ± 17.42 months vs 23 ± 3.85 months (p = 0.030). Poorer treatment results in Group 2 can be explained by a higher proportion of patients with more advanced tumors in this group.Conclusion. The results of the present study do not allow to conclude that combined approach has oncologic advantage over less aggressive transoral approach for tumors with depth of invasion from 10 to 20 mm. It is questionable to recommend the combined approach as a universal one for lesions with such a stage of local invasiveness.
Targeted therapy of anaplastic thyroid cancer
Authors: Nikiforovich P.  A. , Polyakov A. P. , Sleptsov I.   V. , Boyko N.  S. , Gronskaya Yu.  A. , Timofeeva N.   I. , Chernikov R.  A. 
Published: March 2023

Introduction. Anaplastic thyroid cancer (ATC) is a very rare malignant tumor of the thyroid comprising 1–2 % of all thyroid cancers. In this pathology, response rate for standard systemic therapy is less than 15 %, and long-term results remain unsatisfactory. Additionally, there are no data conclusively showing that cytotoxic chemotherapy improves survival or quality of life in patients with ATC.Aim. To improve the results of treatment of patients with ATC through evaluation of the effectiveness of targeted therapy in cases of BRAFV600E mutation.Materials and methods. The multicenter prospective study included 29 patients with ATC IVB–C, T4a–bN1a–bM0–1. The patients were divided into 2 groups. The Group 1 (control) included 15 patients with resectable / nonresectable, metastatic / nonmetastatic ATC (without BRAFV600E mutation), stages IVB–C who received standard types of treatment (surgical intervention, radiation, and chemotherapy). The Group 2 consisted of 14 patients with nonresectable or metastatic ATC, stages IVB–C, who received combination therapy (surgical intervention, radiation, and chemotherapy) with inclusion of inhibitors of BRAF dabrafenib and trametinib in neoadjuvant and adjuvant regimens.Results. The study showed the effectiveness of targeted therapy with inhibitors of BRAF mutations in treatment of locally advanced non-operable metastatic ATC with BRAFV600E mutation. Overall response (complete response + partial response) in the Group 1 was 0 %, in the Group 2 it was 64 %. Therefore, treatment scheme dabrafenib + trametinib is a prmising approach to combination targeted therapy in patients with ATC and BRAFV600E mutation. Conclusion. Dabrafenib + trametinib is a promising combination targeted therapy option for patients with ATC with a BRAFV600 mutation demonstrates a high overall response rate, a prolonged duration of response, and an increase in survival rates with controlled toxicity.
Proton beam therapy in repeat irradiation of recurrent head and neck tumors: analysis of short-term results
Authors: Smyk D. I. , Gulidov I. A. , Gordon K. B. , Gogolin D. V. , Dyuzhenko S. S. , Semenov A. V. 
Published: March 2023

Introduction. Recurrence of head and neck tumors occurs in 50 % of cases and usually has locoregional character. Due to the characteristics of dose distribution, proton beam therapy is a promising treatment option for patients with recurrences of tumors in this location who previously underwent radiation therapy.Aim. To evaluate the effectiveness and tolerability of repeat irradiation using active scanning proton beam therapy in patients with recurrent head and neck tumors who previously underwent radiation therapy.Materials and methods. Between November of 2015 and December of 2020, 40 patients with locoregional recurrence of head and neck tumors underwent treatment using active scanning proton beam therapy at the A. F . Tsyb Medical Radiological Research Center – branch of the National Medical Research Radiological Center. Median cumulative dose of primary irradiation was 64.5 Gy. Median time between primary and repeat irradiation was 35.7 months, mean irradiated volume of the repeat course was 94.5 cm3. Proton beam therapy was performed using standard mode (2 isoGy) and accelerated hypofractionation (2.4 isoGy / 3 isoGy) with mean equivalent cumulative dose of 56.4 Gy (α / β = 10). Radiation toxicity was evaluated using the Radiation Therapy Oncology Group European (RTOG) / Organization for Research and Treatment of Cancer (EORTC) scale.Results. Treatment response was achieved in 34 (85 %) patients: in 17 (42.5 %) patients, stable disease was observed; in 10 (25 %) patients, partial response was observed; and in 7 (17.5 %) patients, complete response was observed. In 6 (15 %) cases, disease progression was diagnosed at first follow-up examination. One- and two-year locoregional control, progression-free survival and overall survival were 58.4 / 19.8; 44.5 / 19.8 and 82.3 / 38.8 % respectively with median follow-up duration of 14.2 months. Median survival was 19.5 months. Grade III and above early radiation toxicity was observed in 3 (7.5 %) patients. In total, 6 (15 %) cases of grade III complications and 2 (5 %) episodes of carotid artery rupture leading to death were observed. Overall frequency of complications of grade III and higher was 20 %.Conclusion. Repeat irradiation using proton beam therapy can be considered an effective and safe treatment method for patients with recurrent head and neck tumors. Dosimetric and radiobiological benefits of proton beams allow to achieve balance between high doses and radiation exposure in previously irradiated tissues.