bluuebunny/crossref_metadata_2025_split huggingface dataset:
INTERNAL CONTROL SYSTEM AND ORGANIZATIONAL COMMITMENT TO REGIONAL GOVERNMENT MANAGERIAL PERFORMANCE
Authors: Basmar Nur Azizah , Rosihan Muhammad Zulfikar 
Published: February 2023

Purpose – This study aims to determine whether the Internal Control System, and Organizational Commitment affect the performance of the Regional Government Managerial in GOWA district SKPD
Design/methodology/approach – The method of data analysis uses multiple linear regression techniques
Findings – The results of this study indicate that the influence of the Internal Control System, and Organizational Commitment has an influence on the Managerial Performance of Local Governments. Based on the results of the R square test in this study is relatively strong. This is because almost all respondents answered strongly agree and agree.
Originality – Collecting data using primary data obtained from 51 respondents in GOWA district SKPD
Kajian Sosio-Yuridis Keistimewaan Yogyakarta Ditinjau Dari Status Daerah Khusus dan Isitimewa Dalam Teori Negara Kesatuan di Negara Kesatuan Republik Indonesia
Authors: Robuan Rahmat 
Published: February 2023

Penulisan dalam penelitian ini bertujuan untuk mengetahui dan menganalisa terkait kajian sosio-yuridis keistimewaan Yogyakarta ditinjau dari status daerah khusus dan istimewa dalam teori negara kesatuan di negara republik Indonesia. Jenis penulisan dalam penelitian ini dengan menggunakan jenis penelitian normatif. Adapun isu hukum permasalahan yang diangkat dalam penulisan jurnal ini yakni, pertama, Apa landasan filosofi masyarakat Yogyakarta terkait keistimewaan Yogyakarta yang menjadikan Yogyakarta sebagai pelopor demokrasi budaya. Kedua, Bagaimana pandangan sosio-yuridis mengenai keistimewaan Yogyakarta. Adapun hasil dari penelitian ini yakni status keistimewaan bagi Daerah Istimewa Yogyakarta dibedakan pada aspek keistimewaan yang mengacu pada aspek sosio-historis, sosio-politik, sosiokultural, dan sosio-spiritual. Status istimewa mengacu pada aturan hukum atas dasar perubahan tata pemerintahan yang awalnya adalah sebuah Kerajaan Ngayogyakarta Hadiningrat menjadi tata pemerintahan demokrasi yang berbentuk provinsi. Kemudian mengenai keistimewaan terletak pada pengangkatan Gubernur dan Wakil Gubernur dengan mempertimbangkan calon keturunan Sri Sultan Hamengku Buwono IV dan Paku Alam VIII yang memenuhi syarat-syarat sesuai undang-undang.
Tinjauan Kriminologis Pembinaan Narapidana Anak Pelaku Penganiayaan di Lembaga Pembinaan Khusus Anak Kelas II Pangkalpinang
Authors: Meliana Yang 
Published: February 2023

Hasil penelitian menunjukkan bahwa terhadap pembinaan narapidana anak pelaku penganiayaan yang dilakukan di (Lembaga Pembinaan Khusus Anak (LPKA) Kelas II Pangkalpinang adalah pendidikan dan pelatihan yang dilakukan oleh tenaga kerja yang tersedia yang harus memiliki kekuatan untuk membina narapidana anak daripada pembinaan terhadap narapidana dewasa.
Sedangkan hasil penelitian terhadap faktor-faktor yang menjadi penyebab terjadinya tindak pidana penganiayaan yang dilakukan oleh anak, antara lain : adanya faktor bullying, faktor mental, faktor lingkungan/pergaulan anak, faktor media massa, dan faktor ekonomi, dan faktor pendidikan.
Intentionnalité, perceptions et stratégies de parents d’enfants présentant des besoins particuliers lors du processus de choix de parcours scolaires au secondaire
Authors: Castonguay-Payant Justine 
Published: February 2023

Depuis le Rapport Parent, le système scolaire québécois permet les choix scolaires entre deux réseaux d’enseignement, l’un public et l’autre privé. Cependant, pour plusieurs parents d’enfants à besoins particuliers, les processus de choix d’une école secondaire s’accompagnent de différentes contraintes (scolaires, familiales). Cette étude examine des processus parentaux de choix scolaires en mariant une approche d’inspiration interactionniste sur les choix scolaires (van Zanten, 2009) et l’approche des parcours de vie. Embrassant une posture compréhensive et interprétative, l’analyse inductive d’entretiens semi-dirigés révèle que différents mécanismes inhérents au processus de choix de l’école secondaire (p. ex., perceptions subjectives et contraintes liées au territoire) peuvent produire des inégalités et réduire le potentiel de ces enfants à leurs difficultés.
Entre maladresse et authenticité : la recherche du plaisir dans Mrs. Fletcher
Authors: Boni Marta 
Published: February 2023

Dans les nouvelles formes de sérialité télévisuelle se dégage une figure de personnages de femmes qui se trouvent en décalage avec la norme, grotesques, dissidentes : cet article propose de se pencher sur un personnage en particulier, la protagoniste de la série Mrs. Fletcher. Cette série de HBO, à cheval entre comédie et drame, met en scène la découverte de la pornographie par une femme de 45 ans, rôle joué par Kathryn Hahn. En analysant la représentation du désir et de la transgression présente dans cette série, nous aborderons l’idée d’un plaisir qui devient forme de connaissance et proposerons une piste de lecture de la sérialité contemporaine à l’aune de la maladresse et de l’authenticité.
Adherence to Healthy Lifestyle Prior to Infection and Risk of Post–COVID-19 Condition
Authors: Wang Siwen , Li Yanping , Yue Yiyang , Yuan Changzheng , Kang Jae Hee , Chavarro Jorge E. , Bhupathiraju Shilpa N. , Roberts Andrea L. 
Published: February 2023

ImportanceFew modifiable risk factors for post–COVID-19 condition (PCC) have been identified.ObjectiveTo investigate the association between healthy lifestyle factors prior to SARS-CoV-2 infection and risk of PCC.Design, Setting, and ParticipantsIn this prospective cohort study, 32 249 women in the Nurses’ Health Study II cohort reported preinfection lifestyle habits in 2015 and 2017. Healthy lifestyle factors included healthy body mass index (BMI, 18.5-24.9; calculated as weight in kilograms divided by height in meters squared), never smoking, at least 150 minutes per week of moderate to vigorous physical activity, moderate alcohol intake (5 to 15 g/d), high diet quality (upper 40% of Alternate Healthy Eating Index–2010 score), and adequate sleep (7 to 9 h/d).Main Outcomes and MeasuresSARS-CoV-2 infection (confirmed by test) and PCC (at least 4 weeks of symptoms) were self-reported on 7 periodic surveys administered from April 2020 to November 2021. Among participants with SARS-CoV-2 infection, the relative risk (RR) of PCC in association with the number of healthy lifestyle factors (0 to 6) was estimated using Poisson regression and adjusting for demographic factors and comorbidities.ResultsA total of 1981 women with a positive SARS-CoV-2 test over 19 months of follow-up were documented. Among those participants, mean age was 64.7 years (SD, 4.6; range, 55-75); 97.4% (n = 1929) were White; and 42.8% (n = 848) were active health care workers. Among these, 871 (44.0%) developed PCC. Healthy lifestyle was associated with lower risk of PCC in a dose-dependent manner. Compared with women without any healthy lifestyle factors, those with 5 to 6 had 49% lower risk (RR, 0.51; 95% CI, 0.33-0.78) of PCC. In a model mutually adjusted for all lifestyle factors, BMI and sleep were independently associated with risk of PCC (BMI, 18.5-24.9 vs others, RR, 0.85; 95% CI, 0.73-1.00, P = .046; sleep, 7-9 h/d vs others, RR, 0.83; 95% CI, 0.72-0.95, P = .008). If these associations were causal, 36.0% of PCC cases would have been prevented if all participants had 5 to 6 healthy lifestyle factors (population attributable risk percentage, 36.0%; 95% CI, 14.1%-52.7%). Results were comparable when PCC was defined as symptoms of at least 2-month duration or having ongoing symptoms at the time of PCC assessment.Conclusions and RelevanceIn this prospective cohort study, pre-infection healthy lifestyle was associated with a substantially lower risk of PCC. Future research should investigate whether lifestyle interventions may reduce risk of developing PCC or mitigate symptoms among individuals with PCC or possibly other postinfection syndromes.
Prevaccination Prevalence of Type-Specific Human Papillomavirus Infection by Grade of Cervical Cytology in Estonia
Authors: Uusküla Anneli , Oja Marek , Tamm Sirli , Tisler Anna , Laanpere Made , Padrik Lee , Nygard Mari , Reisberg Sulev , Vilo Jaak , Kolde Raivo 
Published: February 2023

ImportanceLarge-scale data on type-specific human papillomavirus (HPV) prevalence and disease burden worldwide are needed to guide cervical cancer prevention efforts. Promoting the research and application of health care big data has become a key factor in modern medical research.ObjectiveTo examine the prevaccination prevalence of high-risk HPV (hrHPV) and type distribution by cervical cytology grade in Estonia.Design, Setting, and ParticipantsThis cross-sectional study used text mining and the linking of data from electronic health records and health care claims to examine type-specific hrHPV positivity in Estonia from 2012 to 2019. Participants were women aged at least 18 years. Statistical analysis was performed from September 2021 to August 2022.Main Outcomes and MeasuresType-specific hrHPV positivity rate by cervical cytological grade.ResultsA total of 11 017 cases of cervical cytology complemented with data on hrHPV testing results between 2012 and 2019 from 66 451 women aged at least 18 years (mean [SD] age, 48.1 [21.0] years) were included. The most common hrHPV types were HPV16, 18, 31, 33, 51 and 52, which accounted for 73.8% of all hrHPV types detected. There was a marked decline in the positivity rate of hrHPV infection with increasing age, but the proportion did not vary significantly based on HPV type. Implementation of nonavalent prophylactic vaccination was estimated to reduce the number of women with high-grade cytology by 50.5% (95% CI, 47.4%-53.6%) and the number with low-grade cytology by 27.8% (95% CI, 26.3%-29.3%), giving an overall estimated reduction of 33.1% (95% CI, 31.7%-34.5%) in the number of women with precancerous cervical cytology findings.Conclusions and RelevanceIn this cross-sectional study, text mining and natural language processing techniques allowed the detection of precursors to cervical cancer based on data stored by the nationwide health system. These findings contribute to the literature on type-specific HPV distribution by cervical cytology grade and document that α-9 phylogenetic group HPV types 16, 31, 33, 52 and α-7 phylogenetic group HPV 18 are the most frequently detected in normal-to-high-grade precancerous lesions in Estonia.
Changes in Alcohol Consumption and Risk of Dementia in a Nationwide Cohort in South Korea
Authors: Jeon Keun Hye , Han Kyungdo , Jeong Su-Min , Park Junhee , Yoo Jung Eun , Yoo Juhwan , Lee Jinkook , Kim SangYun , Shin Dong Wook 
Published: February 2023

ImportanceThe impact of serial changes in alcohol consumption on dementia risk has rarely been investigated to date.ObjectiveTo investigate the association of comprehensive patterns of changes in alcohol consumption with the incidence of all-cause dementia, Alzheimer disease (AD), and vascular dementia (VaD).Design, Setting, and ParticipantsThis is a retrospective cohort study. Data were obtained from the Korean National Health Insurance Service database. Adults aged 40 years and older underwent 2 health examinations in 2009 and 2011. The cohort was assessed until December 31, 2018, and statistical analysis was performed in December 2021.ExposuresAlcohol consumption level was categorized into none (0 g per day), mild (&amp;lt;15 g per day), moderate (15-29.9 g per day), and heavy (≥30 g per day) drinking. On the basis of changes in alcohol consumption level from 2009 to 2011, participants were categorized into the following groups: nondrinker, quitter, reducer, sustainer, and increaser.Main Outcomes and MeasuresThe primary outcome was newly diagnosed AD, VaD, or other dementia.ResultsAmong 3 933 382 participants (mean [SD] age, 55.0 [9.6] years; 2 037 948 men [51.8%]), during a mean (SD) follow-up of 6.3 (0.7) years, there were 100 282 cases of all-cause dementia, 79 982 cases of AD, and 11 085 cases of VaD. Compared with sustained nondrinking, sustained mild (adjusted hazard ratio [aHR], 0.79; 95% CI, 0.77-0.81) and moderate (aHR, 0.83; 95% CI, 0.79-0.88) drinking were associated with a decreased risk of all-cause dementia, whereas sustained heavy drinking was associated with an increased risk of all-cause dementia (aHR, 1.08; 95% CI, 1.03-1.12). Compared with sustained levels of drinking, reducing alcohol consumption from a heavy to a moderate level (aHR, 0.92; 95% CI, 0.86-0.99) and the initiation of mild alcohol consumption (aHR, 0.93; 95% CI, 0.90-0.96) were associated with a decreased risk of all-cause dementia. Increasers and quitters exhibited an increased risk of all-cause dementia compared with sustainers. The trends in AD and VaD remained consistent.Conclusions and RelevanceIn this cohort study of a Korean population, decreased risk of dementia was associated with maintaining mild to moderate alcohol consumption, reducing alcohol consumption from a heavy to a moderate level, and the initiation of mild alcohol consumption, suggesting that the threshold of alcohol consumption for dementia risk reduction is low.
PRNP expression predicts imaging findings in sporadic Creutzfeldt‐Jakob disease
Authors: Broce Iris J. , Caverzasi Eduardo , Sacco Simone , Nillo Ryan Michael , Paoletti Matteo , Desikan Rahul S. , Geschwind Michael , Sugrue Leo P. 
Published: February 2023

AbstractObjectiveWe explored the relationship between regional PRNP expression from healthy brain tissue and patterns of increased and decreased diffusion and regional brain atrophy in patients with sporadic Creutzfeldt‐Jakob disease (sCJD).MethodsWe used PRNP microarray data from 6 healthy adult brains from Allen Brain Institute and T1‐weighted and diffusion‐weighted MRIs from 34 patients diagnosed with sCJD and 30 age‐ and sex‐matched healthy controls to construct partial correlation matrices across brain regions for specific measures of interest: PRNP expression, mean diffusivity, volume, cortical thickness, and local gyrification index, a measure of cortical folding.ResultsRegional patterns of PRNP expression in the healthy brain correlated with regional patterns of diffusion signal abnormalities and atrophy in sCJD. Among different measures of cortical morphology, regional patterns of local gyrification index in sCJD most strongly correlated with regional patterns of PRNP expression. At the vertex‐wise level, different molecular subtypes of sCJD showed distinct regional correlations in local gyrification index across the cortex. Local gyrification index correlation patterns most closely matched patterns of PRNP expression in sCJD subtypes known to have greatest pathologic involvement of the cerebral cortex.InterpretationThese results suggest that the specific genetic and molecular environment in which the prion protein is expressed confer variable vulnerability to misfolding across different brain regions that is reflected in patterns of imaging findings in sCJD. Further work in larger samples will be needed to determine whether these regional imaging patterns can serve as reliable markers of distinct disease subtypes to improve diagnosis and treatment targeting.
Crystalline Antibody‐Laden Alginate Particles: A Platform for Enabling High Concentration Subcutaneous Delivery of Antibodies
Authors: Erfani Amir , Schieferstein Jeremy M. , Reichert Paul , Narasimhan Chakravarthy N. , Pastuskovas Cinthia , Parab Vaishali , Simmons Denarra , Yang Xiaoyu , Shanker Apoorv , Hammond Paula , Doyle Patrick S. 
Published: February 2023

AbstractSubcutaneous (SC) administration is a desired route for monoclonal antibodies (mAbs). However, formulating mAbs for small injection volumes at high concentrations with suitable stability and injectability is a significant challenge. Here, this work presents a platform technology that combines the stability of crystalline antibodies with injectability and tunability of soft hydrogel particles. Composite alginate hydrogel particles are generated via a gentle centrifugal encapsulation process which avoids use of chemical reactions or an external organic phase. Crystalline suspension of anti‐programmed cell death protein 1 (PD‐1) antibody (pembrolizumab) is utilized as a model therapeutic antibody. Crystalline forms of the mAb encapsuled in the hydrogel particles lead to stable, high concentration, and injectable formulations. Formulation concentrations as high as 315 mg mL−1 antibody are achieved with encapsulation efficiencies in the range of 89–97%, with no perceivable increase in the number of antibody aggregates. Bioanalytical studies confirm superior maintained quality of the antibody in comparison with formulation approaches involving organic phases and chemical reactions. This work illustrates tuning the alginate particles’ disintegration by using partially oxide alginates. Crystalline mAb‐laden particles are evaluated for their biocompatibility using cell‐based in vitro assays. Furthermore, the pharmacokinetics (PK) of the subcutaneously delivered human anti‐PD‐1 mAb in crystalline antibody‐laden alginate hydrogel particles in Wistar rats is evaluated.
DNA Nanoclusters Combined with One‐Shot Radiotherapy Augment Cancer Immunotherapy Efficiency
Authors: Xie Yuexia , Li Huishan , Xu Lei , Zou Hanbing , Wang Xingang , He Xiaozhen , Tang Qianyun , Zhou Yan , Zhao Xue , Chen Xiaojing , Liu Hongmei , Pu Jun , Luo Dan , Liu Peifeng 
Published: February 2023

AbstractImmunotherapy shows immense promise for improving cancer treatment. Combining immunotherapy with radiotherapy provides a conspicuous advantage due to its enhanced abscopal effect. However, established immune tolerance mechanisms in the tumor microenvironment can hamper the generation of a sufficient abscopal effect. Herein, a type of DNA nanocluster (DNAnc) that is self‐assembled by a CpG‐ODNs‐loaded Y‐shaped double‐stranded DNA vector based on the unique complementary base‐pairing rules is designed. The unique structure of DNAnc makes it load more than ≈8125.5 ± 822.5 copies of CpG ODNs within one single nanostructure, which effectively increases resistance to nuclease degradation and elevates the efficiency of repolarizing macrophages to an M1‐like phenotype. Mechanistic studies reveal that more DNAncs are endocytosed by macrophages in the cancer tissue and repolarized macrophages to elicit a robust abscopal effect with the accumulation of macrophages induced by radiotherapy, generating potent, long‐term, and durable antitumor immunity for the inhibition of tumor metastasis and the prevention of tumor recurrence, which provides a novel strategy to boost cancer immunotherapy.
Blocking Spatiotemporal Crosstalk between Subcellular Organelles for Enhancing Anticancer Therapy with Nanointercepters
Authors: Li Huiyan , Zhang Huilin , He Xiaofang , Zhao Peiran , Wu Tong , Xiahou Jinxuan , Wu Yelin , Liu Yanyan , Chen Yang , Jiang Xingwu , Lv Guanglei , Yao Zhenwei , Wu Jian , Bu Wenbo 
Published: February 2023

AbstractThe spatiotemporal characterization of signaling crosstalk between subcellular organelles is crucial for the therapeutic effect of malignant tumors. Blocking interactive crosstalk in this fashion is significant but challenging. Herein, a communication interception strategy is reported, which blocks spatiotemporal crosstalk between subcellular organelles for cancer therapy with underlying molecular mechanisms. Briefly, amorphous‐core@crystalline‐shell Fe@Fe3O4 nanoparticles (ACFeNPs) are fabricated to specifically block the crosstalk between lysosomes and endoplasmic reticulum (ER) by hydroxyl radicals generated along with their trajectory through heterogeneous Fenton reaction. ACFeNPs initially enter lysosomes and trigger autophagy, then continuous lysosomal damage blocks the generation of functional autolysosomes, which mediates ER–lysosome crosstalk, thus the autophagy is paralyzed. Thereafter, released ACFeNPs from lysosomes induce ER stress. Without the alleviation by autophagy, the ER‐stress‐associated apoptotic pathway is fully activated, resulting in a remarkable therapeutic effect. This strategy provides a wide venue for nanomedicine to exert biological advantages and confers new perspective for the design of novel anticancer drugs.
Dynamic Reconstitution Between Copper Single Atoms and Clusters for Electrocatalytic Urea Synthesis
Authors: Wei Xiaoxiao , Liu Yingying , Zhu Xiaorong , Bo Shuowen , Xiao Lei , Chen Chen , Nga Ta Thi Thuy , He Yuanqing , Qiu Mengyi , Xie Chao , Wang Dongdong , Liu Qinghua , Dong Fan , Dong Chung‐Li , Fu Xian‐Zhu , Wang Shuangyin 
Published: February 2023

AbstractElectrocatalytic CN coupling between carbon dioxide and nitrate has emerged to meet the comprehensive demands of carbon footprint closing, valorization of waste, and sustainable manufacture of urea. However, the identification of catalytic active sites and the design of efficient electrocatalysts remain a challenge. Herein, the synthesis of urea catalyzed by copper single atoms decorated on a CeO2 support (denoted as Cu1–CeO2) is reported. The catalyst exhibits an average urea yield rate of 52.84 mmol h−1 gcat.−1 at −1.6 V versus reversible hydrogen electrode. Operando X‐ray absorption spectra demonstrate the reconstitution of copper single atoms (Cu1) to clusters (Cu4) during electrolysis. These electrochemically reconstituted Cu4 clusters are real active sites for electrocatalytic urea synthesis. Favorable CN coupling reactions and urea formation on Cu4 are validated using operando synchrotron‐radiation Fourier transform infrared spectroscopy and theoretical calculations. Dynamic and reversible transformations of clusters to single‐atom configurations occur when the applied potential is switched to an open‐circuit potential, endowing the catalyst with superior structural and electrochemical stabilities.
Extended Isogeometric Analysis of Cracked Piezoelectric Materials in the Presence of Flexoelectricity
Authors: Unnikrishnan Gokul Krishna , Sharma Saurav , Pathak Himanshu , Chauhan Vishal Singh , Jain Satish Chandra 
Published: February 2023

AbstractTo accurately analyze the fracture behavior of piezoceramics at small length scales, flexoelectricity must be considered along with piezoelectricity. Due to its dependence on size, flexoelectricity predominates at the micro‐ and nano‐length scales. Additionally, crack tips having the largest strain gradient state cause large flexoelectricity around them. Different approaches are employed in the past to model cracks computationally. However, extended isogeometric analysis (XIGA) is proven to be an accurate and efficient method. C1 continuity requirements for modeling gradients in flexoelectricity are met by non‐uniform rational B‐splines (NURBS) basis functions used in XIGA. In this work, XIGA‐based computational model is developed and implemented to study the fracture behavior of the piezoelectric‐flexoelectric domain. An in‐house MATLAB code is developed for the same. Several numerical examples are studied to ensure the efficacy and efficiency of the implemented model, and crack behavior is presented in the form of an electro‐mechanical J‐integral. The analysis is carried out to investigate how cracks behave for different flexoelectric coefficients under different electrical and mechanical loading combinations. J‐integral is also analyzed against crack parameters such as crack orientation and length. It is observed that boundary loads and flexoelectric material constants significantly influence J‐integral. Results also show a considerable amount of fracture toughening in the presence of flexoelectricity. The peak value of J‐integral is found to be reduced with an increase in the flexoelectric coefficient. A significant reduction in J‐integral, as much as 45%, is observed when the flexoelectric constant varied from 0.5 to 2 µCm−1.