bluuebunny/crossref_metadata_2025_split huggingface dataset:
Systematic Workflow and Electrogram guidance to reduce X-ray Exposure Time during cryoballoon ablation of atrial fibrillation: the SWEET-Cryo strategy
Authors: Rodríguez Muñoz Daniel , Marco del Castillo Álvaro , Rajjoub Al-Mahdi Ez Alddin , Lázaro Rivera Carla , Guisasola Cienfuegos María , Ramos Jiménez Javier , Borrego Bernabé Luis , Arribas Ynsaurriaga Fernando , Salguero-Bodes Rafael 
Published: July 2023

Abstract

Aims
Cryoballoon pulmonary vein isolation (CB-PVI) offers similar efficacy to point-by-point radiofrequency PVI for patients with atrial fibrillation (AF), but generally with higher X-ray exposure. Strategies aimed at reducing fluoroscopy mostly rely on other costly imaging techniques, limiting their applicability. We designed a Systematic Workflow and Electrogram guidance to reduce X-ray Exposure Time during CB-PVI (SWEET-Cryo) strategy and analysed its impact on fluoroscopy use and acute procedural and clinical outcomes.

Methods and results
We enrolled 100 patients with paroxysmal or persistent AF undergoing CB-PVI by two operators with different levels of expertise. Patients treated with the SWEET-Cryo strategy (prospective cohort; n = 50) or conventional fluoroscopy (retrospective control cohort; n = 50) were compared. When applied by the senior operator, the SWEET-Cryo strategy significantly reduced the mean fluoroscopy time (FT) (2.6 ± 1.25 vs. 20.3 ± 10.8 min) and mean dose area product (DAP) (5.1 ± 3.8 vs. 35.3 ± 22.3 Gy cm2) compared with those of the control group, respectively (P &lt; 0.001). Significant reductions in FT (6.4 ± 2.5 min vs. 32.5 ± 10.05) and DAP (13.9 ± 7.7 vs. 92.3 ± 63.8) were also achieved by the less experienced operator (P &lt; 0.001). No difference was observed in acute and long-term complications or freedom from AF between fluoroscopy strategies during a 33-month median follow-up. Mean FT was maintained below 3 min in randomly selected cases performed during the follow-up period.

Conclusion
In contrast to conventional protocols and regardless of the operator’s experience, the optimized SWEET-Cryo strategy dramatically reduced fluoroscopy exposure during CB-PVI. The efficacy, safety, or added costs of the ablation procedure were not compromised.
Urine-based Detection of Congenital Portosystemic Shunt in C57BL/6 Mice
Authors: Yeoh Beng San , Golonka Rachel M , Saha Piu , Kandalgaonkar Mrunmayee R , Tian Yuan , Osman Islam , Patterson Andrew D , Gewirtz Andrew T , Joe Bina , Vijay-Kumar Matam 
Published: July 2023

Abstract
Sporadic occurrence of congenital portosystemic shunt (PSS) at a rate of ∼1 out of 10 among C57BL/6 J mice, which are widely used in biomedical research, results in aberrancies in serologic, metabolic, and physiologic parameters. Therefore, mice with PSS should be identified as outliers in research. Accordingly, we sought methods to, reliably and efficiently, identify PSS mice. Serum total bile acids ≥ 40 µm is a bona fide biomarker of PSS in mice but utility of this biomarker is limited by its cost and invasiveness, particularly if large numbers of mice are to be screened. This led us to investigate if assay of urine might serve as a simple, inexpensive, noninvasive means of PSS diagnosis. Metabolome profiling uncovered that Krebs cycle intermediates, that is, citrate, α-ketoglutarate, and fumarate, were strikingly and distinctly elevated in the urine of PSS mice. We leveraged the iron-chelating and pH-lowering properties of such metabolites as the basis for 3 urine-based PSS screening tests: urinary iron-chelation assay, pH strip test, and phenol red assay. Our findings demonstrate the feasibility of using these colorimetric assays, whereby their readout can be assessed by direct observation, to diagnose PSS in an inexpensive, rapid, and noninvasive manner. Application of our urinary PSS screening protocols can aid biomedical research by enabling stratification of PSS mice, which, at present, likely confound numerous ongoing studies.
Dictionary Representation of the Semantics of Adjectives Signifying Emotions
Authors: Halczak Paulina 
Published: July 2023

Abstract
Naming emotions may pose a serious problem for foreign language learners as emotion words constitute a complex semantic field. Here is where monolingual learners’ dictionaries turn out to be useful. The paper reports on a comparative analysis of dictionary representation of the semantics of adjectives signifying emotions. To investigate the treatment of this semantic field, twenty-four adjectives are looked up in the five British pedagogical dictionaries published by Oxford, Cambridge, Longman, Macmillan and Collins. The qualitative analysis concentrates on definitions as primary carriers of meaning. Yet, examples, grammatical information and additional sources of information within a dictionary entry are also given attention. The study demonstrates that some inconsistencies in defining emotion words in individual dictionaries can be spotted. The value of examples is limited: some focus merely on presenting a word’s syntactic properties. Thus, the combination of the definition and the examples both clarifying meaning and illustrating the typical use of the words is judged to best represent meaning. The paper suggests model definitions of adjectives signifying emotions and offers recommendations aiming at improving the representation of their meaning in dictionaries.
Breast cancer care amidst a pandemic: a scoping review to understand the impact of coronavirus disease 2019 on health services and health outcomes
Authors: Myers Charlotte , Bennett Kathleen , Cahir Caitriona 
Published: July 2023

AbstractSince the onset of the coronavirus disease 2019 (COVID-19) pandemic, health services for breast cancer (BC) have been disrupted. Our scoping review examines the impact of the COVID-19 pandemic on BC services, health outcomes, and well-being for women. Additionally, this review identifies social inequalities specific to BC during the pandemic. Using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for scoping reviews guidelines, the literature search was conducted using scientific databases starting from March 2020 through November 2021. Studies were identified and selected by two researchers based on inclusion criteria, and the relevant data were extracted and charted to summarize the findings. Ninety-three articles were included in this review. Main themes included are as follows: (i) the impact of COVID-19 on BC services; (ii) the impact of COVID-19 on health outcomes and well-being in women with BC; and (iii) any variation in the impact of COVID-19 on BC by social determinants of health. There were apparent disruptions to BC services across the cancer continuum, especially screening services. Clinical repercussions were a result of such disruptions, and women with BC experienced worsened quality of life and psychosocial well-being. Finally, there were social inequalities dependent on social determinants of health such as age, race, insurance status, and region. Due to the disruption of BC services during the COVID-19 pandemic, women were impacted on their health and overall well-being. The variation in impact demonstrates how health inequities have been exacerbated during the pandemic. This comprehensive review will inform timely health-care changes to minimize long-term impacts of the pandemic and improve evidence-based multidisciplinary needs.
New Method for Rapid 3D Reconstruction of Semi-Transparent Underwater Animals and Structures
Authors: Daniels Joost , Sainz Giovanna , Katija Kakani 
Published: July 2023

Synopsis
Morphological features are the primary identifying properties of most animals and key to many comparative physiological studies, yet current techniques for preservation and documentation of soft-bodied marine animals are limited in terms of quality and accessibility. Digital records can complement physical specimens, with a wide array of applications ranging from species description to kinematics modeling, but options are lacking for creating models of soft-bodied semi-transparent underwater animals. We developed a lab-based technique that can live-scan semi-transparent, submerged animals, and objects within seconds. To demonstrate the method, we generated full three-dimensional reconstructions (3DRs) of an object of known dimensions for verification, as well as two live marine animals—a siphonophore and an amphipod—allowing detailed measurements on each. Techniques like these pave the way for faster data capture, integrative and comparative quantitative approaches, and more accessible collections of fragile and rare biological samples.
An E-survey study protocol for the perception of African healthcare professionals on the intrathecal injection of antitetanic serum for the treatment of tetanus
Authors: Tangmi Djabo Eric Adrien , Mbougo Voufo Jolyvette , Muili Abdulbasit Opeyemi , Tchato Ngassam Fustel Valmy , Naeem Ahmed , Ibekwe Jonas Lotanna , Emhemed Marwa SaedAli , Asogwa Chukwebuka Stanley , Kyaruzi Victor Meza 
Published: July 2023

Abstract

Background
Tetanus remains a public health neuroinfectious burden in Africa, accounting for the long stay in hospitals. For the past two decades, intrathecal injection of antitetanic serum has been described by several meta-analyses as the therapy for the treatment of tetanus with the best outcome. Particularly with neonatal tetanus, but in Africa, the reality faced by healthcare professionals is in contradiction to the literature. This study aims to assess the perception of healthcare professionals regarding the intrathecal administration of antitetanic serum for the treatment of tetanus, to decide on which action to undertake to preserve patients’ health.

Methodology
Data will be collected through a self-administered Qualtrics questionnaire from a Qualtrics account. The minimum and maximum sample sizes calculated were, respectively, 384 and 426. Anonymous links to the three versions of the questionnaire will be disseminated from 15 May 2023 to 15 July 2023, through mobile phones, social media (WhatsApp, LinkedIn, Telegram) and e-mail. Ata shall be analyzed with SPSS version 26 (IBM, WA, USA). The analyzed data will be presented as frequency tables and charts. Odds ratios and their 95% confidence intervals, Chi-Square test and analysis of variance will be used to test for associations between independent and dependent variables. A P-value &lt;0.05 will be considered statistically significant.

Dissemination
Our study findings will be published in a peer-reviewed journal, and the abstract will be presented at an international conference.
Clinical evaluation of a dermatophyte RT-PCR assay and its impact on the turn-around-time: A prospective study
Authors: Debuysschere Cyril , Blairon Laurent , Cupaiolo Roberto , Beukinga Ingrid , Tré-Hardy Marie 
Published: July 2023

Abstract
Onychomycosis is an important public health problem whose prevalence continues to grow and impact public health at several levels. Nevertheless, today the main diagnostic methods used in routine practice have many drawbacks. The aim of this study was to evaluate, for the first time, the clinical performance of a new multiplex polymerase chain reaction (PCR) (Novaplex®) in the identification of the causative agent on nail samples, and its impact on the turnaround time, compared to our traditional laboratory methods.
From June 2022 to December 2022, all nail samples sent to our laboratory for suspected onychomycosis were included in this prospective study. We collected for each sample the results obtained with the Novaplex® PCR method and with the traditional direct microscopy examination and culture. Each discordant result was checked using a third method, which is another PCR method (DermaGenius® kit) as a resolver. For culture-positive samples, a turnaround time was calculated and compared to the one obtained with the Novaplex® method.
A total of 131 samples were included. Among them, 5 were positive (3.8%) on direct microscopy, 33 were positive (25.2%) after culture, and 98 were negative (74.8%). All positive (n = 33) and negative (n = 69) cultures were also positive/negative with the Novaplex® PCR. Twenty-nine samples were positive with the Novaplex® method but negative with culture (discordant results). The percentage agreement between the culture and the Novaplex® methods was 77.9% (102 out of 131). While tested with the resolver (DermaGenius® PCR), 28 out of 29 discordant results were similarly found positive. The percentage agreement between the two PCR methods (Novaplex® and DermaGenius®) was 96.6%. The Novaplex® PCR method evaluated proved to be very reliable and allowed the direct identification of 62 out of 131 positive samples (47.3%) with the following distribution: 79.0% of Trichophyton rubrum complex, 11.3% of Trichophyton mentagrophytes complex, 6.5% of both Trichophyton rubrum complex and Trichophyton mentagrophytes complex, and 3.2% of Candida albicans. The median time [± 95% CI] for positive culture (between incubation and validation of the final identification) was 15 [12–23] days, while the turnaround time for the Novaplex® method adapted to our clinical laboratory routine is ≤7 days.
Laboratory confirmation of onychomycosis is crucial and should always be obtained before starting treatment. The evaluated PCR method offered a rapid, reliable, robust, and inexpensive method of identification of the causative agent compared to traditional methods.
Testing the dynamic origin of Quasi-periodic Oscillations in MAXI J1535−571 and H 1743−322
Authors: Rawat Divya , Husain Nazma , Misra Ranjeev 
Published: July 2023

ABSTRACT
We investigate spectro-temporal properties for two black hole X-ray binary sources, MAXI J1535−571 and H 1743−322, during their hard and hard-intermediate states. For MAXI J1535−571, we analyse swift/XRT, NuSTAR, and nicer observations, specifically focusing on the occurrence of type-C Quasi-periodic Oscillations (QPOs). Regarding H 1743−322, we analyse multi-epoch observations of nicer and AstroSat, identifying a type-C QPO with centroid frequency ranging from 0.1–0.6 Hz. In both sources, we fit the spectra with a relativistic truncated disc and a power-law component. In MAXI J1535−571, we also observe an additional relativistically smeared iron-line. Through temporal and spectral analysis, we estimate the QPO centroid frequency and spectral parameters, such as the accretion rate and inner disc radii. We test the origin of type-C QPOs as relativistic precession frequency, and dynamic frequency (i.e. the inverse of the sound crossing time $\frac{r}{c_\mathrm{ s}(r)}$). The dependence of QPO frequency on both the accretion rate and inner disc radii favours the QPO origin as dynamic frequency. We discuss the implications of these results.
Mapping the stellar population and gas excitation of MaNGA galaxies with megacubes. Results for AGN versus control sample
Authors: Riffel Rogério , Mallmann Nicolas D , Rembold Sandro B , Ilha Gabriele S , Riffel Rogemar A , Storchi-Bergmann Thaisa , Ruschel-Dutra Daniel , Vazdekis Alexandre , Martín-Navarro Ignacio , Schimoia Jaderson S , Ramos Almeida Cristina , da Costa Luiz N , Vila-Verde Glauber C , Gatto Lara 
Published: July 2023

ABSTRACT
We present spaxel-by-spaxel stellar population fits for the ∼10 000 MaNGA data cubes. We provide multiple extension fits files, nominated as megacubes, with maps of several properties as well as emission-line profiles that are provided for each spaxel. All the megacubes are available through a web interface (https://manga.linea.org.br/ or http://www.if.ufrgs.br/~riffel/software/megacubes/). We also defined a final Active Galactic Nuclei (AGN) sample, as well as a control sample matching the AGN host galaxy properties. We have analysed the stellar populations and spatially resolved emission-line diagnostic diagrams of these AGNs and compared them with the control galaxies sample. We find that the relative fractions of young (t ≤56 Myr) and intermediate-age (100 Myr ≤t ≤ 2 Gyr) show predominantly a positive gradient for both AGNs and controls. The relative fraction of intermediate-age stellar population is higher in AGN hosts when compared to the control sample, and this difference becomes larger for higher [O iii] luminosity AGNs. We attribute this to the fact that extra gas is available in these more luminous sources and that it most likely originates from mass-loss from the intermediate-age stars. The spatially resolved diagnostic diagrams reveal that the AGN emission is concentrated in the inner 0.5 Re (effective radius) region of the galaxies, showing that the AGN classification is aperture dependent and that emission-line ratios have to be taken together with the H α equivalent width for proper activity classification. We present a composite ‘BPT+WHAN’ diagram that produces a more comprehensive mapping of the gas excitation.
Galaxy evolution in compact groups – I. Revealing a transitional galaxy population through a multiwavelength approach
Authors: Montaguth Gissel P , Torres-Flores Sergio , Monachesi Antonela , Gómez Facundo A , Lima-Dias Ciria , Cortesi Arianna , Mendes de Oliveira Claudia , Telles Eduardo , Panda Swayamtrupta , Grossi Marco , Lopes Paulo A A , Hernandez-Jimenez Jose A , Kanaan Antonio , Ribeiro Tiago , Schoenell William 
Published: July 2023

ABSTRACT
Compact groups (CGs) of galaxies show members with morphological disturbances, mainly products of galaxy–galaxy interactions, thus making them ideal systems to study galaxy evolution, in high-density environment. To understand how this environment affects the properties of galaxies, we select a sample of 340 CGs in the Stripe 82 region, for a total of 1083 galaxies, and a sample of 2281 field galaxies as a control sample. By performing a multiwavelength morphological fitting process using Southern Photometric Local Universe Survey data, we divide our sample into early-type galaxies (ETGs), late-type galaxies (LTGs), and transition galaxies using the r-band Sérsic index and the colour (u − r). We find a bimodal distribution in the plane of the effective radius – Sérsic index, where a secondary ‘peculiar’ galaxy population of smaller and more compact galaxies is found in CGs, which is not observed in the control sample. This indicates that galaxies are undergoing a morphological transformation in CGs. In addition, we find significant statistical differences in the distribution of specific star-formation rate (sSFR) when we compare both environments for LTGs and ETGs. We also find a higher fraction of quenched galaxies and a lower median sSFR in CGs than in the control sample, suggesting the existence of environmental effects favouring the cessation of star formation, regardless of galaxy type. Our results support the notion that CGs promote morphological and physical transformations, highlighting their potential as ideal systems for galaxy pre-processing.
Hubble Space Telescope survey of Magellanic Cloud star clusters: UV-dim stars in young clusters
Authors: Milone A P , Cordoni G , Marino A F , Muratore F , D’Antona F , Di Criscienzo M , Dondoglio E , Lagioia E P , Legnardi M V , Mohandasan A , Ziliotto T , Dell’Agli F , Tailo M , Ventura P 
Published: July 2023

ABSTRACT
Young and intermediate-age star clusters of both Magellanic Clouds exhibit complex colour–magnitude diagrams. In addition to the extended main-sequence turn-offs (eMSTOs), commonly observed in star clusters younger than ∼2 Gyr, the clusters younger than ∼800 Myr exhibit split main sequences (MSs). These comprise a blue MS, composed of stars with low rotation rates, and a red MS, which hosts fast-rotating stars. While it is widely accepted that stellar populations with different rotation rates are responsible for the eMSTOs and split MSs, their formation and evolution are still debated. A recent investigation of the ∼1.7-Gyr-old cluster NGC 1783 detected a group of eMSTO stars extremely dim in ultraviolet (UV) bands. Here, we use multiband Hubble Space Telescope photometry to investigate five star clusters younger than ∼200 Myr, including NGC 1805, NGC 1818, NGC 1850, and NGC 2164 in the Large Magellanic Cloud, and the Small Magellanic Cloud cluster NGC 330. We discover a group of bright MS stars in each cluster that are significantly dim in the F225W and F275W bands, similar to what is observed in NGC 1783. Our result suggests that UV-dim stars are common in young clusters. The evidence that most of them populate the blue MS indicates that they are slow rotators. As a by-product, we show that the star clusters NGC 1850 and BHRT 5b exhibit different proper motions, thus corroborating the evidence that they are not gravitationally bound.
On the need of an ultramassive black hole in OJ 287
Authors: Valtonen Mauri J , Zola Staszek , Gopakumar A , Lähteenmäki Anne , Tornikoski Merja , Dey Lankeswar , Gupta Alok C , Pursimo Tapio , Knudstrup Emil , Gomez Jose L , Hudec Rene , Jelínek Martin , Štrobl Jan , Berdyugin Andrei V , Ciprini Stefano , Reichart Daniel E , Kouprianov Vladimir V , Matsumoto Katsura , Drozdz Marek , Mugrauer Markus , Sadun Alberto , Zejmo Michal , Sillanpää Aimo , Lehto Harry J , Nilsson Kari , Imazawa Ryo , Uemura Makoto , Davidson James W 
Published: July 2023

ABSTRACT
The highly variable blazar OJ 287 is commonly discussed as an example of a binary black hole system. The 130 yr long optical light curve is well explained by a model where the central body is a massive black hole of 18.35 $\times$ 109 solar mass that supports a thin accretion disc. The secondary black hole of 0.15 $\times$ 109 solar mass impacts the disc twice during its 12 yr orbit, and causes observable flares. Recently, it has been argued that an accretion disc with a typical Active Galactic Nuclei (AGN) accretion rate and above mentioned central body mass should be at least six magnitudes brighter than OJ 287’s host galaxy and would therefore be observationally excluded. Based on the observations of OJ 287’s radio jet, detailed in Marscher and Jorstad (2011), and up-to-date accretion disc models of Azadi et al. (2022), we show that the V-band magnitude of the accretion disc is unlikely to exceed the host galaxy brightness by more than one magnitude, and could well be fainter than the host. This is because accretion power is necessary to launch the jet as well as to create electromagnetic radiation, distributed across many wavelengths, and not concentrated especially on the optical V-band. Further, we note that the claimed V-band concentration of accretion power leads to serious problems while interpreting observations of other AGN. Therefore, we infer that the mass of the primary black hole and its accretion rate do not need to be smaller than what is determined in the standard model for OJ 287.
On the origin of extreme trans-Neptunian objects within Modified Newtonian Dynamics
Authors: Migaszewski Cezary 
Published: July 2023

ABSTRACT
In this work, we investigate the dynamical origin of extreme trans-Neptunian objects (ETNOs) under the action of the External Field Effect (EFE), which is a consequence of Modified Newtonian Dynamics (MOND) applied to gravity around the Sun embedded in the gravitational field of the Galaxy. We perform N-body integrations of known ETNOs treated as massless particles and perturbed by four giant planets and EFE. Backward integrations show that these objects originated in the giant planet region, from where they were scattered and then evolved to their current orbits. A striking example of such evolution is Sedna, which may have been temporarily in a horseshoe orbit with Jupiter and Saturn only 30 Myr ago. Another interesting example is the newly discovered retrograde ETNOs, whose dynamical connection with prograde ETNOs and Centaurs is shown. The EFE is considered as an alternative to Planet Nine in explaining the anomalous distribution of ETNO orbits, namely the orbital plane clustering and apsidal confinement. We also analyse the effect of MOND on the obliquity of the solar spin with respect to the invariant plane of the solar system.