bluuebunny/crossref_metadata_2025_split huggingface dataset:
Approach and Management of Alcohol Withdrawal Syndrome in Operative Head and Neck Cancer Patients
Authors: Desai Veeral , Lamba Wiplove , de Almeida John , Goldstein David 
Published: February 2023

AbstractPostoperative head and neck cancer patients are at increased risk for alcohol withdrawal syndrome. Literature has shown that in this patient population, alcohol withdrawal is associated with an increase in postoperative medical and surgical complications, length of hospitalization, and hospital‐related costs. Harm reduction and addiction medicine philosophies can reduce morbidity and mortality, but have not been fully validated in perioperative surgical management for head and neck cancer. This commentary synthesizes key principles of addiction medicine and current strategies that Otolaryngology–Head and Neck Surgery surgeons can consider in their perioperative assessment and management of alcohol withdrawal syndrome in their patients.
Regionalization of Head and Neck Oncology Tumor Boards: Perspectives of Collaborating Physicians
Authors: Amin Neha B. , Bridgham Kelly M. , Brown Jessica P. , Moyer Kelly F. , Taylor Rodney J. , Wolf Jeffrey S. , Witek Matthew E. , Molitoris Jason K. , Mehra Ranee , Cullen Kevin J. , Papadimitriou John C. , Raghavan Prashant , Hatten Kyle M. 
Published: February 2023

AbstractObjectivesTo survey academic and community physician preferences regarding the virtual multidisciplinary tumor board (MTB) for further improvement and expansion.Study DesignThis anonymous 14‐question survey was sent to individuals that participated in the head and neck virtual MTBs. The survey was sent via email beginning August 3, 2021, through October 5, 2021.SettingThe University of Maryland Medical Center and regional practices in the state of Maryland.MethodsSurvey responses were recorded and presented as percentages. Subset analysis was performed to obtain frequency distributions by facility and provider type.ResultsThere were 50 survey responses obtained with a response rate of 56%. Survey participants included 11 surgeons (22%), 19 radiation oncologists (38%), and 8 medical oncologists (16%), amongst others. More than 96% of participants found the virtual MTB to be useful when discussing complex cases and impactful to future patient care. A majority of respondents perceived a reduction in time to adjuvant care (64%). Community and academic physician responses strongly agreed that the virtual MTB improved communication (82% vs 73%), provided patient‐specific information for cancer care (82% vs 73%), and improved access to other specialties (66% vs 64%). Academic physicians, more so than community physicians, strongly agreed that the virtual MTB improves access to clinical trial enrollment (64% vs 29%) and can be useful in obtaining CME (64% vs 55%).ConclusionAcademic and community physicians view the virtual MTB favorably. This platform can be adapted regionally and further expanded to improve communication between physicians and improve multidisciplinary care for patients.
Healthcare Provider Feedback Improves Outpatient E/M Billing and Coding in Otolaryngology Clinics
Authors: Gill Amarbir S. , Menjivar Dennis , Shipman Paige , Sumsion Jorgen , Error Marc , Alt Jeremiah A. 
Published: February 2023

AbstractObjectiveDiscrepancies in medical coding can negatively impact institutional revenue and result in accusations of medical fraud. The objective of the present study was to prospectively assess the utility of a dynamic feedback system for otolaryngology providers in improving the coding/billing accuracy of outpatient clinic encounters.MethodsA billing audit of outpatient clinic visits was performed. Dynamic billing/coding feedback, consisting of a virtual lecture and targeted e‐mails, was provided at distinct intervals by the institutional billing and coding department. χ2 was used for categorical data, and the Wilcoxon test was used to compare changes in accuracy over time.ResultsA total of 176 clinic encounters were reviewed. Prior to feedback, 60% of encounters were inaccurately billed by otolaryngology providers, requiring upcoding and representing a potential 35% work relative value unit (wRVU) loss of E/M generated productivity. After 1 year of feedback, providers significantly increased the accuracy of their billing from 40% to 70% (odds ratio [OR]: 3.55, p < .001, 95% confidence interval [CI]: 1.69, 7.29), with a corresponding decrease in potential wRVU loss from 35% to 10% (OR: 4.87, p < .001, 95% CI: 0.81, 10.51).DiscussionDynamic billing feedback significantly improved outpatient E/M coding among otolaryngology healthcare providers in this study.Implications for PracticeThis study demonstrates that educating providers on appropriate medical coding and billing policies, while providing dynamic, intermittent feedback, may improve billing accuracy, translating into appropriate charges and reimbursements for services provided.
Tailoring high mechanical performances of self‐healable poly(vinyl alcohol)‐based elastomers via judicious grafting of side chains
Authors: Xu Xingran , Li Zili , Huang Yanwei , Zhang Ziying , Xiong Shisheng 
Published: February 2023

AbstractSelf‐healing conductive materials have become promising candidates for flexible sensor devices. However, the mechanical properties of the substrate elastomers are often poor due to the inherent performance of the materials. Here, a poly(vinyl alcohol) (PVA)‐based self‐healing material with high strength and good thermal stability was prepared by side‐linked grafting modification of PVA with a one‐step esterification reaction. Benefiting from the hydrogen bonds and ion coordination between iron ions and carboxyl groups, the synthesized elastomer exhibited excellent mechanical properties (tensile strength of 38.6 MPa, fracture elongation of 1565.0%) and good self‐healing performance (self‐healing efficiency of 53.4% at room temperature). In addition, the high sensitivity and self‐healing performance of a silver nanowire‐coated elastomer strain sensor demonstrated the wide potential applicability of the prepared PVA‐based elastomers in health care, electrocardiography and safety monitoring. © 2023 Society of Industrial Chemistry.
Registration of ‘MT Sidney’ hard red spring wheat
Authors: Crutcher Frankie K. , Lamb Peggy F. , Nash Deanna , Fiedler Jason D. , Eberly Jed , Kephart Kenneth D. , McVay Kent , Torrion Jessica , Beiermann Clint W. , Vetch Justin M. , Chen Chengci , Holen Doug , Blake Nancy K. , Heo Hwa‐Young , Cook Jason P. 
Published: February 2023

Abstract‘MT Sidney’ (Reg. no. CV‐1199; PI 699957) hard red spring wheat (Triticum aestivum L.) was released by the Montana Agricultural Experiment Station in January 2021 as a new cultivar adapted to Montana's rainfed growing environments. MT Sidney was a selection from the cross MT1274/‘RB07’ and was tested in Montana as experimental line MT1716 from 2018 to 2020. MT1274 is an unreleased, Montana experimental line, and RB07 was released by the University of Minnesota in 2007 for high yield, moderate Fusarium head blight (FHB) resistance, and good end‐use quality. MT Sidney was in the top‐yielding statistical group in our advanced yield trial that includes ‘Vida’ (PI 642366), the most widely grown cultivar in Montana. MT Sidney also has significantly higher test weight and an earlier heading date than Vida. Multiple years of FHB resistance screening indicate MT Sidney is moderately resistant to FHB. MT Sidney was released based on high yield potential, high test weight, early heading date, and moderate FHB resistance.
Prospective role of 3βHSD1 in prostate cancer precision medicine
Authors: Zhuang Qian , Huang Shengsong , Li Zhenfei 
Published: February 2023

AbstractBackgroundProstate cancer is addicted to androgens. The steroidogenic enzyme 3β‐hydroxysteroid dehydrogenase 1 (3βHSD1) recognizes pregnenolone, dehydroepiandrosterone (DHEA), and steroidal medicine abiraterone as substrates to accelerate disease progression.MethodsReferences for this review were identified through searches of PubMed with the search terms “prostate cancer”, “HSD3B1”, and “3bHSD1” from 1990 until June, 2022.ResultsGenotype of 3βHSD1 has been reported to correlate with tumor aggressiveness of advanced prostate cancer in multiple clinical scenarios. The ethnic differences and limitations of using 3βHSD1 genotype as a prognostic biomarker have been discussed here. The activity of 3βHSD1 increases in patients treated with abiraterone and enzalutamide, giving rise to treatment resistance. Further elucidation of 3βHSD1 regulatory mechanisms will shed light on more approaches for disease intervention. We also review the recent advance on 3βHSD1 inhibitors and targeting 3βHSD1 for prostate cancer management. Novel 3βHSD1 inhibitors will be needed to provide additional options for prostate cancer management.Conclusion3βHSD1 is both a predictive biomarker and a promising therapeutic target for prostate cancer.
Managerialization, professionalization and firm performance in family business: A Systems Thinking perspective
Authors: Songini Lucrezia , Armenia Stefano , Morelli Chiara , Pompei Alessandro 
Published: February 2023

AbstractThis paper proposes a systemic model on the intertwined relations among managerialization, professionalization and firm economic performance, considering both business‐ and family‐specific features and issues. It sheds light on the role that, in the family business, the firm economic performance may play in favouring a positive development of both the business and the family itself. It aims at understanding how, in family businesses, the firm managerialization and professionalization may represent relevant drivers of firm performance. A Systems Thinking model based on causal loop diagrams was developed, to provide a clear framing of the interrelationships among the various aspects at stake. The conceptual model combines with systemic perspective all the variables and relationships that come into play when considering jointly the growth and development of the company and the family. This paper provides not only a conceptual background but also practical insights for family business' owners, managers and consultants.
Rheological characterization of linear low‐density polyethylene–Fischer–Tropsch wax blends
Authors: Mhlabeni Thobile , Ngobese Cebo , Ramjee Shatish , Focke Walter 
Published: February 2023

AbstractThe thermal and rheological behavior of blends of a Fischer–Tropsch (F‐T) wax with linear low‐density polyethylene (LLDPE) were investigated by differential scanning calorimetry and cone‐and‐plate rheometry. F‐T wax is used as a possible low‐cost processing aid alternative for LLDPE masterbatch applications. The melting‐ and crystallization thermograms indicated a two‐phase solid‐state morphology and full compatibility in the fully molten material. Both the high‐melting and low‐melting phase contained co‐crystalized wax and polymer. Rheological data of F‐T wax‐LLDPE blends over the full composition range was also obtained. The zero‐shear viscosity data was adequately predicted by the Friedman and Porter mixing rule: with α = 3.4. This implies that the melt viscosity is dominated by the effects of polymer chain entanglement and that the main consequence of adding the wax is to reduce the concentration of the polymer present. The complex viscosity also fitted this model albeit with α = 4.81. All Han plots, that is, plots of the logarithm of the storage modulus (G') against the logarithm of the loss modulus (G"), were linear. Within the experimental uncertainty, they were essentially unaffected by variations in blend composition, temperature and the applied angular frequency. Additionally, Cole–Cole plots were also in agreement that wax‐LLDPE blends are miscible at melt state. This supports full miscibility of the F‐T wax‐LLDPE blend system down to temperatures as low as 120°C.
TRIPS: Co-design as a Method for Accessible Design in Transport
Authors: Vasconcelos Elvia , Andersen Kristina , Alčiauskaitė Laura , König Alexandra , Hatzakis Tally , Launo Carolina 
Published: February 2023

AbstractCo-design is an established method for ensuring a more democratic approach to design and change propositions. It is however not without friction. In this chapter we describe parts of a process aimed at co-designing inclusive transport systems. In response to the friction of putting such theory into practice, we propose a set of coping mechanisms based on participant feedback. We suggest that such mechanisms have the potential to improve the co-design process beyond this particular case.
Subjectification, Technology, and Rationality – Sustainable Transformation of the Mobility Sector from a Governmentality Perspective
Authors: Hansel Julia , Graf Antonia 
Published: February 2023

AbstractShared mobility services play an essential role in a sustainable mobility transition and unfold among so-called smart technologies. Although this can positively affect mobility, it also poses challenges for the development of sustainable urban mobility, for example, because the smart options are not equally available to all people or are inaccessible. Issues of social or ecological inequality as well as the digital exclusion of people in the mobility sector are increasingly becoming the focus of attention. Largely unexplored in this context is how the subjects of shared mobility services will be conceived, and what knowledge, skills, and resources they should bring to use smart and shared mobility services in the future. We contribute to closing this research gap by investigating the rationalities that sustainable smart and shared mobility transformation follow, which developments are triggered by the technologies, and in which ways identification offers address subjects. Foucault’s concept of governmentality is used as a theoretical perspective and nuanced with critical (feminist) literature on identity formation. Methodologically, this article works with qualitative content analysis of policy documents and an ethnographically oriented observation of registration conditions in various car-, bike-, electronic moped, and scooter-sharing services. The results show that subjects are addressed in a rather general way, and their (special) needs are hardly considered. Instead, they are addressed as flexible citizen-consumers and correspond with the rationality of (green) economic growth and the liberal paradigm. Accordingly, the technologies aim for innovation, fair competition, and the provision of public space by the state.
Creating a More Inclusive and Accessible Digital Transport System: Developing the INDIMO Inclusive Service Evaluation Tool
Authors: Delaere Hannes , Basu Samyajit , Keseru Imre 
Published: February 2023

AbstractThe introduction of smart technologies in mobility has created a vast landscape of possibilities and options, but at the same time they have also created uneven impacts across society. It is, therefore, the goal of this paper to introduce the online Service and Policy Evaluation Tool (SPET) for evaluating the accessibility and inclusivity of digital mobility and delivery services. The tool shall enable policy makers to design strategies necessary for all citizens to fully benefit from the digital mobility system (e.g. social and educational strategies, new regulations, etc.) and identify strategies to avoid digital exclusion in terms of social and spatial aspects. Structurally, the tool is built on the capabilities approach, in combination with the principles of universal design, and co-creation was used for the development of the tool contents. The recommendations from the SPET will assist policy makers, developers, operators and other parties to provide promised benefits of digital services to all sections of the society, especially to people vulnerable to exclusion.
Integrating Inclusive Digital Mobility Solutions into German Transport Systems
Authors: Pinto Alexandra , Leitão Joana , Wilsch Benjamin 
Published: February 2023

AbstractDigital technologies constitute an essential building block for the modernisation of transport systems and their sustainability. Since improvements in usability and accessibility are intrinsic to most digital solutions, their integration in mobility systems may further contribute to an increased inclusiveness. Nonetheless, digital solutions could potentially exclude vulnerable groups by not catering to their specific needs. Inclusiveness can, however, be maximised when individual technologies are established with such goals in mind and are accompanied by the necessary development of the required (hardware) infrastructure. The widespread introduction of digital applications was triggered by a major German funding programme aiming at enhancing digitalisation in German municipal transport systems to improve air quality. Given the versatility and high adaptability of digital solutions, the substantial progress toward that objective unlocked a high potential for a more inclusive mobility system, so that further improvements in this direction have become low-hanging fruit that can be easily reaped with further projects and funding directed immediately at this objective. The potential of digital solutions to contribute to various societal and thus political objectives, particularly inclusiveness, is identified in this chapter through an analysis of projects that serve as a collection of successful real-world examples.
Leaving No One Behind: Involving Users in Creating Inclusive Digital Mobility
Authors: Bulanowski Kathryn , Lima Sandra , Marlier Evelien 
Published: February 2023

AbstractWith a shift towards the digitisation of mobility services, user involvement is vital for success. Especially critical is the inclusion of groups vulnerable to exclusion, so they can equally benefit from such services. In this respect, the Inclusive Digital Mobility Solutions (INDIMO) project established a multidisciplinary perspective on digital mobility services by considering the needs and concerns of vulnerable-to exclusion groups such as those who lack digital skills, belong to an ethnic minority or have reduced mobility.Using data collection methods such as interviews and surveys targeted at vulnerable persons in five pilot locations, we collected information about user needs, intentions and preferences when using a digital mobility service. In this paper, we provide insights into the user recruitment process for this study and share tips for working with groups vulnerable to exclusion. Not to be forgotten are the lessons learnt from conducting this research during the COVID-19 pandemic.
INDIMO Communities of Practice in Monghidoro, Antwerp, Galilée, Madrid, and Berlin: A Common Space for Co-designing Inclusive Digital Mobility Solutions
Authors: Di Ciommo Floridea , Tu Eleonora , Devis Juanita , Specktor Michelle , Shiftan Yoram , Jaenike Miguel , Rondinella Gianni , Acosta Esau , Lamoza Thais , Schuss Martina , Nys Arne 
Published: February 2023

AbstractThis paper demonstrates the co-creation process of digital mobility and delivery services applied in the Inclusive Digital Mobility Solutions (INDIMO) project mainly based on the local Communities of Practice (CoP) drawing on the knowledge and experience of their members to propose solutions adapted to their needs and interests. In the context of the INDIMO project, CoPs were established at five pilot locations and included users, mobility service providers, (digital) developers, user interface designers, and policymakers associated with each pilot. This chapter aims to report on the experience of the INDIMO project in employing the CoP as a tool to integrate the development of digital mobility and delivery services and the contribution and cooperation of different actors such as operators, developers, policymakers, and organizations representing the end-users. The creation of common spaces such as the INDIMO communities of practice was fundamental to enhance cooperation among different actors, co-design inclusive digital mobility solutions, and empower the participants in using the above-mentioned services. This chapter shows the development of the CoP process, the activities and challenges, and its role in making digital mobility services inclusive and universally usable.
Chronic in situ tissue cooling does not reduce lignification at the Swiss treeline but enhances the risk of ‘blue’ frost rings
Authors: Körner Christian , Lenz Armando , Hoch Günter 
Published: February 2023

AbstractIn their 2013 paper, Lenz et al. illustrated how trees growing at the low-temperature limit respond to a chronic in situ warming or cooling by 3 K, by employing Peltier-thermostated branch collars that tracked ambient temperatures. The micro-coring-based analysis of seasonal tree ring formation included double-staining microtome cross sections for lignification, but these data had not been included in the publication. In this short communication, we complement these data, collected in 2009 at the Swiss treeline, and we show that a 3 K cooling that corresponds to a 500–600 m higher elevation, had no influence on lignification. However, when a frost event occurred during the early part of ring formation, the 3 K cooling produced a blue (non-lignified) layer of cells, followed by normally lignified cells for the rest of the season. Hence, the event did not affect the cambium, but interrupted cell wall maturation in cells that were in a critical developmental stage. We conclude, that chronic cooling does not affect lignification at treeline, but it increases the risk of frost damage in premature xylem tissue.
Hemispheric asymmetries in mental disorders: evidence from rodent studies
Authors: Mundorf Annakarina , Ocklenburg Sebastian 
Published: February 2023

AbstractThe brain is built with hemispheric asymmetries in structure and function to enable fast neuronal processing. In neuroimaging studies, several mental disorders have been associated with altered or attenuated hemispheric asymmetries. However, the exact mechanism linking asymmetries and disorders is not known. Here, studies in animal models of mental disorders render important insights into the etiology and neuronal alterations associated with both disorders and atypical asymmetry. In this review, the current literature of animal studies in rats and mice focusing on anxiety and fear, anhedonia and despair, addiction or substance misuse, neurodegenerative disorders as well as stress exposure, and atypical hemispheric asymmetries is summarized. Results indicate overall increased right-hemispheric neuronal activity and a left-sided behavioral bias associated with symptoms of anxiety, fear, anhedonia, behavioral despair as well as stress exposure. Addiction behavior is associated with right-sided bias and transgenic models of Alzheimer’s disease indicate an asymmetrical accumulation of fibrillar plaques. Most studies focused on changes in the bilateral amygdala and frontal cortex. Across studies, two crucial factors influencing atypical asymmetries arose independently of the disorder modeled: sex and developmental age. In conclusion, animal models of mental disorders demonstrate atypical hemispheric asymmetries similar to findings in patients. Particularly, increased left-sided behavior and greater right-hemispheric activity were found across models applying stress-based paradigms. However, sex- and age-dependent effects on atypical hemispheric asymmetries are present that require further investigation. Animal models enable the analysis of hemispheric changes on the molecular level which may be most effective to detect early alterations.