bluuebunny/crossref_metadata_2025_split huggingface dataset:
Left ventricular electrical potential measured by the NOGA XP electromechanical mapping method as a predictor of response to cardiac resynchronization therapy
Authors: Wilczek Jacek , Jadczyk Tomasz , Wojakowski Wojciech , Gołba Krzysztof S. 
Published: May 2023

ObjectivesThe aim of the study was to determine whether left ventricular electrical potential measured by electromechanical mapping with the NOGA XP system has predictive value for response to CRT.BackgroundApproximately 30% of patients who undergo cardiac resynchronization therapy do not see the expected effects.MethodsThe group of 38 patients qualified for CRT implantation were included in the study, of which 33 patients were analyzed. A 15% reduction in ESV after 6 months of pacing was used as a criterion for a positive response to CRT. The mean value and sum of unipolar and bipolar potentials obtained by mapping with the NOGA XP system and their predictive value in relation to the effect of CRT were analyzed using a bulls-eye projection at three levels: 1) the global value of the left ventricular (LV) potentials, 2) the potentials of the individual LV walls and 3) the mean value of the potentials of the individual segments (basal and middle) of the individual LV walls.Results24 patients met the criterion of a positive response to CRT vs. 9 non-responders. At the global analysis stage, the independent predictors of favorable response to CRT were the sum of the unipolar potential and bipolar mean potential. In the analysis of individual left ventricular walls, the mean bipolar potential of the anterior and posterior wall and in the unipolar system, mean septal potential was found to be an independent predictor of favorable response to CRT. In the detailed segmental analysis, the independent predictors were the bipolar potential of the mid-posterior wall segment and the basal anterior wall segment.ConclusionsMeasurement of bipolar and unipolar electrical potentials with the NOGA XP system is a valuable method for predicting a favorable response to CRT.
Evaluation of transitions from early hypertension to hypertensive chronic kidney disease, coronary artery disease, stroke and mortality: a Thai real-world data cohort
Authors: Teza Htun , Boonmanunt Suparee , Unwanatham Nattawut , Thadanipon Kunlawat , Limpijankit Thosaphol , Pattanaprateep Oraluck , Pattanateepapon Anuchate , McKay Gareth J. , Attia John , Thakkinstian Ammarin 
Published: May 2023

ObjectiveSystemic arterial hypertension (HT) is a major modifiable risk factor for cardiovascular disease (CVDs), associated with all-cause death (ACD). Understanding its progression from the early state to late complications should lead to more timely intensification of treatment. This study aimed to construct a real-world cohort profile of HT and to estimate transition probabilities from the uncomplicated state to any of these long-term complications; chronic kidney disease (CKD), coronary artery disease (CAD), stroke, and ACD.MethodsThis real-world cohort study used routine clinical practice data for all adult patients diagnosed with HT in the Ramathibodi Hospital, Thailand from 2010 to 2022. A multi-state model was developed based on the following: state 1-uncomplicated HT, 2-CKD, 3-CAD, 4-stroke, and 5-ACD. Transition probabilities were estimated using Kaplan-Meier method.ResultsA total of 144,149 patients were initially classified as having uncomplicated HT. The transition probabilities (95% CI) from the initial state to CKD, CAD, stroke, and ACD at 10-years were 19.6% (19.3%, 20.0%), 18.2% (17.9%, 18.6%), 7.4% (7.1%, 7.6%), and 1.7% (1.5%, 1.8%), respectively. Once in the intermediate-states of CKD, CAD, and stroke, 10-year transition probabilities to death were 7.5% (6.8%, 8.4%), 9.0% (8.2%, 9.9%), and 10.8% (9.3%, 12.5%).ConclusionsIn this 13-year cohort, CKD was observed as the most common complication, followed by CAD and stroke. Among these, stroke carried the highest risk of ACD, followed by CAD and CKD. These findings provide improved understanding of disease progression to guide appropriate prevention measures. Further investigations of prognostic factors and treatment effectiveness are warranted.
An escalating continuum of learning and attention difficulties from premutation to full mutation in female carriers of FMR1 expansion
Authors: Gabis Lidia V. , Shaham Meirav , Attia Odelia Leon , Kowal Tamar , David Sivan , Banet-Levi Yonit , Shefer Shahar , Gabis Daniel , Mula-Topf Dana , Avrech Bar Michal , Bart Orit , Segal Osnat 
Published: May 2023

ObjectiveCarriers of Fragile X premutation may have associated medical comorbidities, such as Fragile X-associated tremor and ataxia (FXTAS) and Fragile X-associated premature ovarian insufficiency (FXPOI). We examined the Fragile X premutation effect on cognition, and we assumed that there is a direct correlation between the continuous spectrum of specific learning and attention deficits to the number of CGG repeats on the FMR1 gene.MethodsA total of 108 women were referred to our center due to a related Fragile X syndrome (FXS) patient, 79 women carried a premutation of 56–199 repeats, and 19 women carried a full mutation of more than 200 CGG repeats on FMR1 gene. Genetic results of CGG repeats, demographic information, structured questionnaires for ADHD, learning disabilities of language and mathematics, and independence level were analyzed in women carrying the FMR1 premutation and compared to the group carrying the full mutation. Women with FXS and FXTAS were excluded.ResultsWhen analyzed as a continuum, there was a significant increase in the following complaints which were associated with a higher number of repeats: specific daily function skills such as driving a car, writing checks, disorientation in directions, and also specific learning difficulties such as spelling and math difficulties. Additionally, when tested as a categorical independent variable, we observe that women with the full mutation were more likely to have ADHD or other learning disability diagnoses in the past than during premutation (&lt;200 CGG repetitions).ConclusionSpecific learning and attention difficulties and resulting daily function difficulties correlate with an increased number of CGG repeats and are more likely to be associated as a common feature of premutation and full mutation in a female premutation carrier. Despite evidence of learning and attention difficulties, it is encouraging that most female carriers of the premutation and full mutation function well in most areas. Nevertheless, they face significant difficulties in specific areas of functioning such as driving, and confusion in times and schedules. Those daily function skills are mostly impacted by dyscalculia, right and left disorientation, and attention difficulties. This may aid to design specific interventions to address specific learning deficits in order to improve daily function skills and quality of life.
Evaluating brain modularity benefits of an acting intervention: a discriminant-analysis framework
Authors: Rajesh Aishwarya , Betzel Richard , Daugherty Ana M. , Noice Tony , Noice Helga , Baniqued Pauline L. , Voss Michelle W. , Kramer Arthur F. 
Published: May 2023

PurposeAging is associated with a reduction in brain modularity as well as aspects of executive function, namely, updating, shifting, and inhibition. Previous research has suggested that the aging brain exhibits plasticity. Further, it has been hypothesized that broad-based intervention models may be more effective in eliciting overall gains in executive function than interventions targeted at specific executive skills (e.g., computer-based training). To this end, we designed a 4-week theater-based acting intervention in older adults within an RCT framework. We hypothesized that older adults would show improvements in brain modularity and aspects of executive function, ascribed to the acting intervention.Materials and methodsThe participants were 179 adults from the community, aged 60–89 years and on average, college educated. They completed a battery of executive function tasks and resting state functional MRI scans to measure brain network modularity pre- and post-intervention. Participants in the active intervention group (n = 93) enacted scenes with a partner that involved executive function, whereas the active control group (n = 86) learned about the history and styles of acting. Both groups met two times/week for 75-min for 4 weeks. A mixed model was used to evaluate intervention effects related to brain modularity. Discriminant-analysis was used to determine the role of seven executive functioning tasks in discriminating the two groups. These tasks indexed subdomains of updating, switching, and inhibition. Discriminant tasks were subject to a logistic regression analysis to determine how post-intervention executive function performance interacted with changes in modularity to predict group membership.ResultsWe noted an increase in brain modularity in the acting group, relative to pre-intervention and controls. Performance on updating tasks were representative of the intervention group. However, post-intervention performance on updating did not interact with the observed increase in brain modularity to distinguish groups.ConclusionAn acting intervention can facilitate improvements in modularity and updating, both of which are sensitive to aging and may confer benefits to daily functioning and the ability to learn.
Molecular characteristics of multiple primary pulmonary nodules under a three-dimensional reconstruction model and relevant multi-omics analyses: a case report
Authors: Luo Zhilin , Xiao Yajie , Luo Chengwen , Zhang Liping , Zhou Runquan , Zhao Zhikun , Sun Chao , Wu Dongfang , Wang Tianhu 
Published: May 2023

BackgroundIn addition to CT images and pathological features, many other molecular characteristics remain unknown about multiple primary lung cancer (MPLC) from intrapulmonary metastatic lung cancer.Case presentationIn this study, we reported a patient with an early-stage MPLC with both adenocarcinoma in situ (AIS) subtype and minimally invasive adenocarcinoma (MIA) subtype. The patient was diagnosed with more than 10 nodules and underwent precise surgery assisted by three-dimensional (3D) reconstruction at the left upper lung lobe. Whole-exome sequencing (WES) and multiple immunohistochemistry (mIHC) were performed to reveal the genomic profiling and tumor microenvironments of multiple nodules in this patient with MPLC. Based on 3D reconstruction location information, we found that the genomic and pathological results of adjacent lymph nodes were quite different. On the other hand, PD-L1 expression and the proportion of infiltrating lymphocytes in tumor microenvironments were all at a low status and did not vary in adjacent lymph nodes. Additionally, maximum diameter and tumor mutational burden levels were found to be significantly associated with CD8+ T cell proportion (p&lt;0.05). Besides, CD163+ macrophages and CD4+ T cell proportion were higher in MIA nodules than in AIS nodules (p&lt;0.05). This patient reached a recurrence-free survival of 39 months.ConclusionGenerally, in addition to CT imaging and pathological results, genomic profiling and tumor microenvironments may facilitate identifying the potential molecular mechanisms and clinical outcomes in patients with early-stage MPLC.
Development and validation of the novel subclassification of pN3 for patients with esophageal cancer
Authors: Ma Keru , Wang Hao , Fang Chengyuan , Jiang Xiangyu , Ma Jianqun 
Published: May 2023

BackgroundPatients with stage pN3 esophageal cancer (EC) have a large number of metastatic lymph nodes (mLNs) and have poor prognosis. This study was to elucidate whether subclassification of pN3 according to the number of mLNs could improve the discrimination ability of EC patients.MethodsThis study retrospectively analyzed patients with pN3 EC from the Surveillance, Epidemiology, and End Results (SEER) database as a training cohort and SEER validation cohort. Patients with pN3 esophageal cancer from the Affiliated Cancer Hospital of Harbin Medical University were used as the validation cohort. The optimal cutoff value of mLNs was identified using the X-tile software, and group pN3 into pN3-I and pN3-II based on mLNs. Kaplan-Meier method and log-rank test were used to analyze the disease-specific survival (DSS). The Cox proportional hazards regression analysis was used to identify the independent prognostic factors.ResultsFor the training cohort, patients with 7 to 9 mLNs were categorized as pN3-I, while those with more than 9 mLNs were categorized as pN3-II. There were 183 (53.8%) pN3-I and 157 (46.2%) pN3-II. The 5-year DSS rates of pN3-I and pN3-II in the training cohort were 11.7% and 5.2% (P=0.033), and the pN3 subclassification was an independent risk factor associated with patient prognosis. More RLNs may not improve patient prognosis, but the use of mLNs/RLNs is effective in predicting patient prognosis. Furthermore, the pN3 subclassification was well validated in the validation cohort.ConclusionSubclassification of pN3 can better distinguish survival differences in EC patients.
Effects of a neuromuscular training program on physical performance and asymmetries in female soccer
Authors: Roso-Moliner Alberto , Mainer-Pardos Elena , Cartón-Llorente Antonio , Nobari Hadi , Pettersen Svein Arne , Lozano Demetrio 
Published: May 2023

Introduction: Women’s football require optimal neuromuscular system development for injury prevention and performance optimization. Standardized neuromuscular training programs have shown promising results in reducing injuries and functional asymmetries, but evidence on their impact on performance is limited.Methods: This research examined the effects of a 10-week neuromuscular training program on physical performance and asymmetries in female football players. Thirty-eight female players from two Spanish Second Division women’s football teams participated in the study. The physical performance tests used were: ankle dorsiflexion, bilateral and unilateral horizontal jump, bilateral and unilateral vertical countermovement jump, 40 m sprint including partial times at 10, 20 and 30 m and the 505 test for change of direction evaluation. For 10 weeks, players in the experimental group performed three weekly 24-min neuromuscular training sessions. Participants in the control group completed their normal 24-min strength and conditioning program.Results: The main results were that maximal linear velocity and change of direction skills showed the most notable improvements [effect size (ES), 0.46 to 0.59] after implementation of the training program, ankle dorsiflexion and jumping skills, also improved although, to a lesser extent (ES, &lt;0.35) while asymmetries between limbs were reduced. Maximal running speed improved in the intervention group (p &lt; 0.001) with a mean ES −0.59.Discussion: We conclude that a 10-week neuromuscular training program can be a sufficient stimulus to improve football-specific performance variables in high-level female football players. Therefore, female players and coaches should be aware that weekly inclusion of strength, power and dynamic balance exercises following a neuromuscular paradigm is helpful for football-specific performance improvement.
Validity and reliability of a Chinese version of the Bergen Work Addiction Scale
Authors: Liu Yuanyuan , Tian Hongjun , Chen Xinying , Jia Feng , Li Ranli , Sun Yun , Chen Langlang , Zhu Jingjing , Jiang Deguo , Zhuo Chuanjun 
Published: May 2023

BackgroundWork addiction (WA), which can impair personal relationships, engagement in recreational activities, and/or health, is a behavioral addiction. A tool for the early detection of WA in China is needed.ObjectiveThe aim of this study was to develop and determine the validity and reliability of a Chinese version of the Bergen Work Addiction Scale (C-BWAS).MethodsTwo hundred social workers who provided post-discharge services for adolescents with non-suicidal self-injury (NSSI) were enrolled in this study. The construct validity of the C-BWAS was assessed by confirmatory factor analysis (CFA). Criterion validity was assessed by conducting Pearson correlation analyses of C-CWAS scores with Hamilton Depression Scale (HAM-D) and Hamilton Anxiety Scale (HAM-A) scores. Cronbach’s α and the intra-class correlation coefficient (ICC) were used to evaluate the reliability of the C-BWAS.ResultsCFA confirmed a one-dimensional structure of the C-BWAS with good construct validity indices [comparative fit index (CFI) = 0.964, Tucker–Lewis index (TLI) = 0.951, root-mean-square error of approximation (RMSEA) = 0.079, and minimum discrepancy Ĉ/degrees of freedom (Cmin/DF) = 0.362]. The standardized regression weights ranged from 0.523 to 0.753. All C-BWAS items loaded on one major factor (loading weights, 0.646–0.943). Coefficients of correlation between C-BWAS scores and HAM-D and HAM-A scores were 0.889 and 0.933, respectively. The Cronbach’s α coefficient and ICC for the instrument was 0.837 and 0.905, respectively.ConclusionThe presently developed C-BWAS showed very good reliability and acceptably validity. It can be employed as a useful tool for assessing WA severity in social workers who provide post-discharge services for adolescents with NSSI.
Secular trends and sociodemographic determinants of thinness, overweight and obesity among Chinese children and adolescents aged 7–18 years from 2010 to 2018
Authors: Li Chengyue , Zhang Mingxuan , Tarken Alimujiang Yimiti , Cao Yuping , Li Qian , Wang Hao 
Published: May 2023

BackgroundMost studies have focused on overweight/obesity and its secular trend, with insufficient studies on the factors influencing thinness and trends recently. To examine the trends of prevalence and sociodemographic determinants of thinness, overweight, and obesity among Chinese children and adolescents aged 7 to 18 years from 2010 to 2018.MethodsThis study was based on cross-sectional data of 11,234 children and adolescents aged 7 to 18 years from the Chinese Family Panel Studies (CFPS) in 2010, 2014, and 2018, including anthropometric and sociodemographic characteristics variables. The nutritional status of each individual was determined according to China and WHO criteria. The demographic characteristics of different subgroups were tested by chi-square, and log-binomial regression was used to analyze the trend of prevalence and the relationship between sociodemographic characteristics and different nutritional statuses.ResultsAfter adjusting for age, from 2010 to 2018, the overall prevalence of thinness decreased, and the prevalence of overweight increased in Chinese children and adolescents. The overall prevalence of obesity declined in boys and increased in girls, but in adolescents aged 16–18 years, it increased significantly. Log-binomial regression analysis showed that among all subjects, time (years), 16–18 years were negatively associated with thinness, while 13–15 years, walking to school, large family size, and paternal age at childbirth older than 30 years old were positively associated with thinness; 10–12/13–15/16–18 years, boarding at school, medium and large family sizes, and mother's education at junior middle school/junior high school and above were negatively associated with overweight/obesity, while time (years), boys were positively associated with overweight/obesity in the multivariate model by adjusting for the statistically significant factors (all p &lt; 0.05).ConclusionChinese children and adolescents are facing a double burden of malnutrition. Future public health policies and interventions should prioritize high-risk groups specifically young age groups, boys, larger family sizes and so on.
Experiences in the training of specialist family and community nurses: a qualitative study
Authors: Sánchez-Muñoz Francisca , Fernández-Medina Isabel María , Granero-Molina José , Suazo-Galdames Iván Claudio , Nunez-Nagy Susana , Ventura-Miranda María Isabel , Ruíz-Fernández María Dolores 
Published: May 2023

IntroductionThe specialist Family and Community Nurse Practitioner (FCNP) is a professional who, after a period of training, is qualified to be part of multidisciplinary teams in primary care. The aim of this study was to describe and understand the experiences of nurses during their training process in the specialty of Family and Community Nursing in Spain.MethodsA descriptive qualitative study was carried out. Participants were recruited by means of convenience sampling from January to April 2022. Sixteen specialist nurses in Family and Community Nursing from different autonomous communities in Spain participated in the study. Twelve individual interviews and one focus group were conducted. Data were analyzed following a thematic analysis method in ATLAS.ti 9.ResultsThe results showed two themes and six subthemes: (1) Residency period, more than a training: (a) Training during the residency period; (b) Specializing through a constant struggle; (c) Moderate optimism about the future of the specialty; and (2) A journey from illusion to disappointment: (a) Beginning of the residency: feeling special; (b) During the residency: between satisfaction and misunderstanding; (c) At the end of the residency: power and frustration.ConclusionsThe residency period is important in the training and acquisition of competencies for the Family and Community Nurse Practitioner. Improvements are needed to ensure quality training during residency and to help give visibility to the specialty.
Dengesiz Metin Sınıflandırmada Öznitelik Seçim Yöntemlerinin Etkililiği
Authors: TİRYAKİ Hande , UYSAL Alper Kürşat 
Published: May 2023

Metin verilerinin sınıflar arasında dağılımı genellikle eşit değildir. Bu durum, metin sınıflandırma
işleminde sınıflandırıcıların performansına olumsuz yansımaktadır. Dengesiz metin sınıflandırma ile ilgili
birçok çalışma yapılmıştır. Metin sınıflandırma işleminin önemli aşamalarından olan öznitelik seçim
aşaması, dengesiz metin probleminde de kritik öneme sahiptir. Öznitelik seçme metotlarının dengesiz
metinlerin sınıflandırılması üzerindeki etkisi bu çalışmada etraflıca araştırılmıştır. Bu doğrultuda, iki
farklı veri seti üzerinde üç farklı sınıflandırıcı ve dokuz farklı öznitelik seçim metodu ile birçok deney
yapılmıştır. Ayrıca öznitelik seçim yöntemlerinin başarıları farklı öznitelik sayılarında da gözlemlenmiştir.
NDM, DFSS, PFS, POISSON, CHI2, IG, GINI, DFS ve MDFS olarak adlandırılan 9 farklı öznitelik seçim
metodu değerlendirilmiştir. Destek Vektör Makinesi (SVM), Karar Ağacı (DTREE) ve Basit Bayes (MNB)
sınıflandırıcıları ile deneysel sonuçlar elde edilmiştir. Reuters-21578 veri setinde DFS ve CHI2 öznitelik
seçim yöntemleri Makro-F1 değerlendirme metriği üzerinden yaklaşık en yüksek 80 değerini alırken,
SPAM SMS veri setinde, DFS öznitelik seçim yöntemi en yüksek skor olarak 95 ve CHI2 öznitelik seçim
yöntemi 94 değerlerini almıştır. Öznitelik seçme metotlarından DFS ve CHI2’nin dengesiz metin
sınıflandırmada daha başarılı olduğu görülmektedir.
Magnetic and electric properties of spinel oxide CoV2O4 (001) films
Authors: Hidaka Atsushi , Koizumi Hiroki , Yanagihara Hideto 
Published: May 2023

Abstract
The epitaxial film growth of CoV2O4 (CVO) on a MgO (001) substrate was successfully achieved using a reactive co-sputtering technique. To explore the conductive CVO films at RT, we grew the films under various conditions, including oxygen-gas flow rates and input radio-frequency power for each target. The Néel temperature of the film was approximately 160 K, which is consistent with previously reported values for bulk CVO. The film was found to be conductive over a wide temperature range and exhibited a negative resistivity temperature coefficient. The mechanism governing the temperature-dependent resistivity of the film can be explained using the one-dimensional variable range-hopping model, at least for temperatures higher than the Néel temperature. The CVO films exhibited a lattice constant close to that of spinel ferrites; therefore, they can be used as conductive buffer layers for electrodes in spintronic applications.