bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impaired glymphatic system as evidenced by low diffusivity along perivascular spaces is associated with cerebral small vessel disease: a population-based study
Authors: Tian Yu , Cai Xueli , Zhou Yijun , Jin Aoming , Wang Suying , Yang Yingying , Mei Lerong , Jing Jing , Li Shan , Meng Xia , Wei Tiemin , Liu Tao , Wang Yongjun , Pan Yuesong , Wang Yilong 
Published: April 2023

ObjectiveThis study aims to investigate the associations of glymphatic system with the presence, severity and neuroimaging phenotypes of cerebral small vessel disease (CSVD) in a community-based population.MethodThis report included 2219 community-dwelling people aged 50–75 years who participated in the PolyvasculaR Evaluation for Cognitive Impairment and vaScular Events cohort. The diffusivity along perivascular spaces based on diffusion tensor imaging (DTI-ALPS index) was measured to assess glymphatic pathway. The presence and severity of CSVD were estimated using a CSVD score (points from 0 to 6) and a modified CSVD score (points from 0 to 4), which were driven by 4 neuroimaging features of CSVD, including white matter hyperintensity (WMH), enlarged perivascular spaces (EPVS), lacunes, cerebral microbleeds. Brain atrophy (BA) was also evaluated. Binary or ordinal logistic regression analyses were carried out to investigate the relationships of DTI-ALPS index with CSVD.ResultThe mean age was 61.3 (SD 6.6) years, and 1019 (45.9%) participants were men. The average DTI-ALPS index was 1.67±0.14. Individuals in the first quartile (Q1) of the DTI-ALPS index had higher risks of the presence of CSVD (OR 1.77, 95% CI 1.33 to 2.35, p<0.001), modified presence of CSVD (odds ratio (OR) 1.80, 95% CI 1.38 to 2.34, p<0.001), total burden of CSVD (common OR (cOR) 1.89, 95% CI 1.43 to 2.49, p<0.001) and modified total burden of CSVD (cOR 1.95, 95% CI 1.51 to 2.50, p<0.001) compared with those in the fourth quartile (Q4). Additionally, individuals in Q1 of the DTI-ALPS index had increased risks of WMH burden, modified WMH burden, lacunes, basal ganglia-EPVS and BA (all p<0.05).ConclusionA lower DTI-ALPS index underlay the presence, severity and typical neuroimaging markers of CSVD, implying that glymphatic impairment may interact with CSVD-related pathology in the general ageing population.Trial registration numberNCT03178448.
Effects of sugarcane extract on growth and diarrhea of growing piglets
Authors: Wang Kai , Ren Xin , Shen Xiangxing , Li Yansen , Xia Yangchun , Li Zhaojian , Li Chunmei 
Published: April 2023

This experiment evaluated the effects of sugarcane extract (SCE) on growing pigs' diarrhea incidence, serum immunity, intestinal morphology, and antioxidant enzyme activity. A total of 116 52-day-old commercial pigs (Duroc × Landrace × Jiaxing Black, average weight of 11 ± 1 kg) were randomly allocated to control (CON, basal diet) and 1% SCE group (SCEG, basal diet + 1% SCE). The experiment lasted four weeks. Compared with CON, diarrhea incidence (SCEG: 74.11% versus CON: 54.76%) and diarrhea index (SCEG: 83.65% versus CON: 73.61%) dropped largely in pigs supplemented with SCE. Villus height in the duodenum ( p < 0.01) and the ratio of villus height to crypt depth ( p < 0.05) increased in SCEG. Dietary SCE enhanced the activity of catalase (CAT) capacity, and decreased tumor necrosis factor α, and malondialdehyde levels in serum ( p < 0.05). CAT activity in the ileum increased ( p < 0.05) in piglets supplemented with SCE. Thus, dietary supplementation with SCE improved diarrhea incidence, serum antioxidant capacity and immunity, and intestinal villus morphology and may be used as an efficient antibiotic alternative in weaned piglet feed.
Echoes of black holes in Einstein-nonlinear electrodynamic theories
Authors: Sang Aofei , Zhang Ming , Wei Shao-Wen , Jiang Jie 
Published: April 2023

AbstractBlack hole echo is an important observable that can help us better understand gravitational theories. The non-linear electrodynamic black holes can admit multi-horizon, and the destruction of outer horizons does not violate the weak cosmic censorship, which leads to the multi-peak effective potential for the scalar perturbations and give rise to the echoes. Putting the initial wave packet released outside the peaks, we find that the time-domain profile of the echo will split when the peaks of the effective potential change from two to three. This is a distinctive phenomenon of black hole echo and it might be possible to determine the geometric structure of the non-linear electrodynamic black hole. We also analyse the properties of echo produced by different kinds of effective potentials.
A positive cosmological constant as a geometrical artifact
Authors: Apostolopoulos Pantelis S. , Tsipogiannis Christos 
Published: April 2023

In this paper, we revisit the classical mechanism to produce [Formula: see text]-dimensional spacetimes via Kaluza–Klein compactification. We made the assumption that the [Formula: see text]-dimensional bulk geometry [Formula: see text] admits a Homothetic Vector Field (HVF) [Formula: see text] relaxing the existence of a zero i.e. [Formula: see text] holds on [Formula: see text] and the homothetic bivector [Formula: see text]. Under these circumstances, we identify the origin of a positive cosmological constant in the [Formula: see text]-dimensional spacetime as the homothetic factor representing a geometrical artifact of late time state of the [Formula: see text]-dimensional bulk spacetime.
Preclinical Profile of BYON3521 Predicts an Effective and Safe MET Antibody–Drug Conjugate
Authors: Groothuis Patrick G. , Jacobs Daniëlle C.H. , Hermens Inge A.T. , Damming Désirée , Berentsen Kim , Mattaar-Hepp Ellen , Stokman Marloes E.M. , Boekel Tinie van , Rouwette Myrthe , van der Vleuten Monique A.J. , Sesink Aloys , Dijcks Fred A. , Coumans Ruud G.E. , Schouten Jan , Glaudemans Dirk H. , Wijk Daniëlle van , Blomenröhr Marion , Kappers Wendela A. , Ubink Ruud , van der Lee Miranda M.C. , Dokter Wim H.A. 
Published: April 2023

Abstract
MET, the cell-surface receptor for the hepatocyte growth factor/scatter factor, which is widely overexpressed in various solid cancer types, is an attractive target for the development of antibody-based therapeutics. BYON3521 is a novel site-specifically conjugated duocarmycin-based antibody–drug conjugate (ADC), comprising a humanized cysteine-engineered IgG1 monoclonal antibody with low pmol/L binding affinity towards both human and cynomolgus MET. In vitro studies showed that BYON3521 internalizes efficiently upon MET binding and induces both target- and bystander-mediated cell killing. BYON3521 showed good potency and full efficacy in MET-amplified and high MET–expressing cancer cell lines; in moderate and low MET–expressing cancer cell lines good potencies and partial efficacy were observed. In mouse xenograft models, BYON3521 showed significant antitumor activity upon single-dose administration in multiple non-MET–amplified tumor types with low, moderate, and high MET expression, including complete tumor remissions in models with moderate MET expression. In the repeat-dose Good Laboratory Practice (GLP) safety assessment in cynomolgus monkeys, BYON3521 was well tolerated and based on the observed toxicities and their reversibility, the highest non-severely toxic dose was set at 15 mg/kg. A human pharmacokinetics (PK) model was derived from the PK data from the cynomolgus safety assessments, and the minimal efficacious dose in humans is estimated to be in the range of 3 to 4 mg/kg. In all, our nonclinical data suggests that BYON3521 is a safe ADC with potential for clinical benefit in patients. A first-in-human dose-escalation study is currently ongoing to determine the maximum tolerated dose and recommended dose for expansion (NCT05323045).
Theology’s Concern for Wellbeing and Human Flourishing: A Research Program
Authors: Oviedo Lluis 
Published: April 2023

Abstract
This article proposes a new perspective for theology calling for fresh studies on religion and coping, resilience, wellbeing and flourishing. These studies have grown far from theological areas and could be seen as quite strange to that tradition, its methods, and views. However, theology can learn a lot from these new studies when trying to update its message of salvation, endowing it with a more explicit content and can offer interesting points to other treaties, like Christian Anthropology and Practical Theology. To that end the article reports and briefly reviews those relevant developments, tries to address several doubts and to connect better theology with that research, after assuming a more pragmatic and empirical stance.
The Chinese Textual Tradition of the Story of The King and His Dreams: An Analytical Investigation of Two Unstudied Recensions of the Story
Authors: Dehghani Farsani Yoones 
Published: April 2023

Abstract
This article provides the first translation into a European language of a barely-studied Chinese version (i.e., Yijing’s version) of a story found in Kalīla wa-Dimna known as “The King and His Dreams.” The article then compares the story with three versions from the Arabic textual tradition. Moreover, discussing the structure and content of this story, yet another unstudied Chinese version (i.e., Kinkara’s version) of the story is introduced. Both Chinese texts belong to the Chinese Buddhist canon (Taishō Tripiṭaka). Our study shows that of the two Chinese texts, Kinkara’s version bears less similarity to the three Arabic versions in terms of structure and content. Yijing’s text and the three Arabic versions are very close, but display in a number of scenes discrepancies in the general plot as well as in details, thereby creating different morals for the story in the two traditions. While the Arabic versions can be regarded as belonging to political advice literature, Yijing’s version remains a story with a religious moral. The variances between Yijing’s text and the three Arabic texts could partly be ascribed to possible adjustment of the original Sanskrit text of the story by the compiler-author of the Middle Persian Kalīla wa-Dimna in order to make the story adaptable to the agenda and the context of his book. Yijing’s text shows distinct similarities to the Tibetan version of the story.
De Ikoon Van Jezus' Doop in de Jordaan
Authors: Jacobs A. 
Published: April 2023

L’icône du baptème de Jésus dans le Jourdain
Le baptème du Christ est une des images les plus anciennes de l’iconographie chrétienne. On la trouve déjà au 3e siècle. Le bapteme était un thème important à cause de la manifestation du Christ comme Fils-de Dieu et de la révélation du mystère de la Trinité. Avec le baptème le Christ commence sa mission sur terre.
A partir du 5e siècle la composition des différents éléments est déjà fixe. II n’y a que des nuances et des détails qui varient.
II existe un lien étroit entre l’icône du baptème et celle de la résurrection. Le Christ descend dans l’eau du Jourdain, symbole du mal et de la mort, et il sort de l’eau comme signe de la rédemption. L’icône de la résurrection nous montre le Christ descendant dans les ténèbres pour déliver tous ceux qui attendent la rédemption.
Intercomparison between Ground-Based and Spaceborne Radars’ Echo-Top Heights: Application to the Multi-Radar Multi-Sensor and the Global Precipitation Measurement
Authors: Mandement Marc , Kirstetter Pierre , Reeves Heather 
Published: April 2023

Abstract
The accuracy and uncertainty of radar echo-top heights estimated by ground-based radars remain largely unknown despite their critical importance for applications ranging from aviation weather forecasting to severe weather diagnosis. Because the vantage point of space is more suited than that of ground-based radars for the estimation of echo-top heights, the use of spaceborne radar observations is explored as an external reference for cross comparison. An investigation has been carried out across the conterminous United States by comparing the NOAA/National Severe Storms Laboratory Multi-Radar Multi-Sensor (MRMS) system with the space-based radar on board the NASA–JAXA Global Precipitation Measurement satellite platform. No major bias was assessed between the two products. An annual cycle of differences is found, driven by an underestimation of the stratiform cloud echo-top heights and an overestimation of the convective ones. The investigation of the systematic biases for different radar volume coverage patterns (VCP) shows that scanning strategies with fewer tilts and greater voids as VCP 21/121/221 contribute to overestimations observed for high MRMS tops. For VCP 12/212, the automated volume scan evaluation and termination (AVSET) function increases the radar cone of silence, causing overestimations when the echo top lies above the highest elevation scan. However, it seems that for low echo tops the shorter refresh rates contribute to mitigate underestimations, especially in stratiform cases.
Satisfaction of Patients Other Than COVID-19 During the Pandemic at a Multidisciplinary Centre with COVID-19 Services
Authors: Sah Mukesh Kumar , Yadav Manoj Kumar , Silwal Shruti , Raut Randip , Joshi Arabind 
Published: April 2023

Background The services rendered by hospitals during the pandemic may not be efficient. This might impact the satisfaction of patients seeking healthcare. The aim of this study is to assess the satisfaction level of patients other than those with COVID-19 during the pandemic with different services provided by the hospital. Method A quantitative, analytical and cross-sectional study was carried out in a multidisciplinary hospital. Valid questionnaire, derived from PSQ III and PSQ 18, was used for data collection from 250 outpatients. Ethical approval was obtained. Systematic random sampling was done to enrol patients into the study after taking their consent. Descriptive analysis was performed using frequency, proportion, median and inter-quartile range. Mann–Whitney U test and Kruskal–Wallis test were carried out to find the association between overall satisfaction and different socio-demographic and other variables. Statistical significance was set at p-value < 0.05. Result Almost two-thirds of the respondents visiting the hospital during the pandemic were female (male: 35.6% and female: 64.4%). More than half (50.4%) of the patients reported that access to the hospital was feasible. Of the patients reporting dissatisfaction, most of them (86.4%) considered the establishment of separate COVID-19 hospitals as the best option. The median satisfaction score for the overall satisfaction of patients towards different service domains was 54.0 (45–60). Almost all respondents (95.6%) found that services were easily available. Patient satisfaction score was significantly associated with expenditure ( p < 0.001). Satisfaction score was also significantly associated with the time spent in the hospital by the patients ( p < 0.001). Conclusion Majority of the patients reporting to the multidisciplinary hospital were satisfied with the provisioning of treatment and different services during the COVID-19 pandemic. Relatively lesser satisfaction was reported for the provision of maintenance of social distance, availability of hand washing/sanitisation, overall hospital cleanliness and cost of treatment. Moreover, satisfaction among patients was associated with their perceived fear of the pandemic.
A Randomized Control Trial Testing a Medication Safety Dashboard in Veteran Transplant Recipients
Authors: Taber David J. , Milfred-LaForest Sherry , Rife Kelsey , Felkner Rebecca , Cooney Danielle , Super Nicholas , McClelland Samantha , Buchanan Casey 
Published: April 2023

Introduction Medication errors, adverse events, and nonadherence in organ transplant recipients are common and can lead to suboptimal outcomes. A medication safety dashboard was developed to identify issues in medication therapy. Research Questions Can a multicenter bioinformatics dashboard accurately identify clinically relevant medication safety issues in US military Veteran transplant recipients? Design The dashboard was tested through a 24-month, prospective, cluster-randomized controlled multicenter study. Pharmacists used the dashboard to identify and address potential medication safety issues, which was compared with usual care. Results Across the 10 sites (5 control sites and 5 intervention sites), 2012 patients were enrolled (1197 intervention vs 831 control). The mean age was 65 (10) years, 95% male, and 27% Black. The dashboard produced 18 132 alerts at a rate of 0.61(0.32) alerts per patient-month, ranging from 0.44 to 0.72 across the 5 intervention sites. Lab-based issues were most common (83.4%), followed by nonadherence (9.4%) and transitions in care (6.4%); 56% of alerts were addressed, taking an average of 43 (29) days. Common responses to alerts included those already resolved by another provider (N = 4431, 44%), the alert not clinically relevant (N = 3131, 31%), scheduling of follow-up labs (N = 591, 6%), and providing medication reconciliation/education (N = 99, 1%). Inaccurate flags significantly decreased over the study by a mean of −0.6% per month (95% CI −0.1 to −1.0; P = .0265), starting at 13.4% and ending at 2.6%. Conclusion This multicenter cluster-randomized controlled trial demonstrated that a medication safety dashboard was feasibly deployable across the VA healthcare system, creating valid alerts.
Primary Spontaneous Pneumothorax Outcomes in Children: A National Analysis
Authors: Huerta Carlos Theodore , Saberi Rebecca A. , Gilna Gareth P. , Ramsey Walter A. , Kodia Karishma , Parreco Joshua , Thorson Chad M. , Sola Juan E. , Perez Eduardo A. 
Published: April 2023

Objective: Considerable variation in primary spontaneous pneumothorax (PSP) management exists in the pediatric population. This study aims to compare nationwide outcomes of children with PSP. Methods: The Nationwide Readmissions Database (2016 to 2018) was used to identify patients 1 to 18 years old with PSP. Trauma, secondary pneumothoraces, and elective admissions were excluded. Demographics and complications were compared among patients undergoing initial nonoperative management (NOM; observation or percutaneous drainage) or operative resection using standard statistical tests. Results: A total of 3,890 patients were identified with PSP (median age, 16 [interquartile range 14 to 17] years). Most (78%) underwent NOM, of which 17% failed requiring operative resection. Of the intent-to-treat cohort, 28% failed NOM during index admission or required repeat percutaneous drainage or operative resection on readmission. Patients treated by NOM had higher 30-day and overall readmission rates compared with operative resection (all P < 0.001). Ipsilateral recurrent pneumothorax was higher in those receiving NOM (13% vs 3%, P < 0.001). Patients from the lowest median household income quartile more frequently received NOM compared with the highest income quartile (82% vs 76%) with more readmissions. Conclusions: Patients with PSP who underwent initial NOM experienced higher readmission rates than those receiving operative resection. Furthermore, socioeconomic status was associated with the utilization of nonoperative versus operative management.
Propensity for Clinically Meaningful Improvement and Surgical Failure After Anterior Cruciate Ligament Repair
Authors: Batista Jorge Pablo , Maestu Rodrigo , Barbier Jose , Chahla Jorge , Kunze Kyle N. 
Published: April 2023

Background: Primary repair of the anterior cruciate ligament (ACL) confers an alternative to ACL reconstruction in appropriately selected patients. Purpose: To prospectively assess survivorship and to define the clinically meaningful outcomes after ACL repair. Study Design: Case series; Level of evidence, 4. Methods: Included were consecutive patients with Sherman grade 1-2 tears who underwent primary ACL repair with or without suture augmentation between 2017 and 2019. Patient-reported outcomes (Lysholm, Tegner, International Knee Documentation Committee, Western Ontario and McMaster Universities Osteoarthritis Index, and Knee injury and Osteoarthritis Outcome Score [KOOS] subscales) were collected preoperatively and at 6 months, 1 year, and 2 years postoperatively. The minimal clinically important difference (MCID) was calculated using a distribution-based method, whereas the Patient Acceptable Symptom State (PASS) and substantial clinical benefit (SCB) were calculated using an anchor-based method. Plain radiographs and magnetic resonance imaging (MRI) were obtained at 6 months, 1 year, and 2 years postoperatively. Results: A total of 120 patients were included. The overall failure rate was 11.3% at 2 years postoperatively. Changes in outcome scores required to achieve the MCID ranged between 5.1 and 14.3 at 6 months, 4.6 and 8.4 at 1 year, and 4.7 and 11.9 at 2 years postoperatively. Thresholds for PASS achievement ranged between 62.5 and 89 at 6 months, 75 and 89 at 1 year, and 78.6 and 93.2 at 2 years postoperatively. Threshold scores (absolute/change based) for achieving the SCB ranged between 82.8 and 96.4/17.7 and 40.1 at 6 months, between 94.7 and 100/23 and 45 at 1 year, and between 95.3 and 100/29.4 and 45 at 2 years. More patients achieved the MCID and PASS at 1 year compared with 6 months and 2 years. For SCB, this trend was also observed for non-KOOS outcomes, while for KOOS subdomains, more patients achieved the SCB at 2 years. High-intensity signal of the ACL repair (odds ratio [OR], 31.7 [95% CI, 1.5-73.4]; P = .030) and bone contusions on MRI (OR, 4.2 [95% CI, 1.7-25.2]; P = .041) at 1 year postoperatively were independently associated with increased risk of ACL repair failure. Conclusion: The rate of clinically meaningful outcome improvement was high early after ACL repair, with the greatest proportion of patients achieving the MCID, PASS, and SCB at 1 year postoperatively. Bone contusions involving the posterolateral tibia and lateral femoral condyle as well as high repair signal intensity at 1 year postoperatively were independent predictors of failure at 2 years postoperatively.