bluuebunny/crossref_metadata_2025_split huggingface dataset:
Advances in Exosome Research in the Management of Lung Cancer
Authors: Shen Huiqing , Cao Dawei , Zhang Xinri 
Published: May 2023

Abstract:
Lung cancer is one of the most common malignant tumors, and its death rate is much higher than that of colon, kidney, breast, and prostate cancers, and its 5-year survival rate is only 18%. Lung cancer has no specific clinical symptoms in its early stages and lacks effective detection, making early detection difficult. The survival rate for advanced lung cancer is meager, with a medi-an survival of only 12 months for stage IIIB/IV non-small cell lung cancer treated with platinum-based chemotherapy. Exosomes could provide vital information for the early diagnosis of lung can-cer and have the potential to become a tumor marker for lung cancer. In addition, scientists have proposed encouraging ways to treat lung cancer by loading drugs, proteins, microRNAs, and siR-NAs into exosomes. Therefore, studying lung cancer exosomes and exosomal nano drugs will pro-vide new ideas and approaches for the diagnosis and treatment of lung cancer. This paper reviews the progress of research on the biological functions of exosomes and exosomal nanomedicines and their applications in clinical practice.
Investigation of the Dyeing Ability of Some Reactive Triazine Azo Dyes
Containing Pyrazole Fragment
Authors: Omar Alaa Z. , Mohamed Mohamed G. , Hamed Ezzat A. , El-Atawy Mohamed A. 
Published: May 2023

Abstract:
A series of reactive disperse dyes bearing azo and cyanuric groups were synthesized, and their structures were established using spectral and elemental analyses.

Methods:
The IR, 1H NMR, and DFT studies indicated that the prepared reactive disperse dyes predominately exist as hydrazone tautomers. The electronic absorption spectra in methanol were observed and compared to those computed using B3LYP/6-311G(d,p). The dyeing efficiency of the produced dispersed reactive dyes was examined on polyester, cotton, and polyester/cotton blended fabrics.

Results:
The degree of exhaustion and the fastness properties of the dyed samples in terms of perspiration, washing, scorch and light fastness were assessed. It was found that reactive disperse dyes under investigation have a higher affinity for dyeing polyester textiles than cotton textiles.

Conclusion:
Moreover, the reflectance and color strength of the synthesized dyes were measured and discussed.
Design, Antimicrobial Testing, and Molecular Docking Studies of New Chalcone and Pyrimidine Derivatives based on 2-phenyl-1H-pyrazol-3(2H)-one
Authors: Alolayan Ruba A. , Elkanzi Nadia A.A. , Hrichi Hajer , Dhafer Cyrine El Baher , Zahou Faten M. , Bakr Rania B. 
Published: May 2023

Background & Objectives:
Heterocyclic pyrimidine and pyrazole rings have attracted the interest
of medicinal chemists because of their pharmacological potential including antimicrobial activity.
Based on molecular hybridization, new chalcones 6a-g and pyrimidines 7a-g based on a pyrazole scaffold
were designed.

Methods:
The synthesis of these compounds involved mild condensation reactions between compound 4
and various aromatic aldehydes in a mixture of ethanol/NaOH (95:5 v/v) to give the corresponding chalcones
6a-g. These chalcones were further reacted with urea in the presence of a base in ethanol to produce
the pyrimidine derivatives 7a-g. These new candidates were screened for their in vitro antimicrobial activities
and molecular docking studies were evaluated.

Results:
The antibacterial and antifungal studies of all synthesized compounds against the strains tested
showed that compounds 6c, d, and 7c, d exhibited the highest antibacterial and antifungal activities. In
addition, the structure-activity relationship and docking studies are discussed.

Conclusion:
The synthesized compounds 6c, 6d, 7c, and 7d showed the highest antibacterial and antifungal
activities against the tested strains.
Ionic Liquids as a Non-conventional Catalyst for the Synthesis of
N-heterocycles
Authors: Singh Pradeep Pratap , Kanodia Saraswati , Ambika  
Published: May 2023

Abstract:
Ionic liquids (ILs) have emerged as one of the potential alternates of organic solvents in
chemistry. Nitrogen-containing heterocyclic compounds are the important structural motifs of some
bioactive compounds. A variety of ILs, such as first-generation, second-generation, and thirdgeneration
ILs have been used in the synthesis of various types of nitrogen-containing heterocyclic
compounds, such as aziridine, indole, pyrrazole, imidazole, oxazole, thiazole, triazole, pyridine, pyrimidine,
quinolones, benzodiazapiene and their derivatives. Due to their unique chemical and physical
properties, ILs can act as both solvent and catalyst and have contributed towards high efficiency, improved
yield and recyclability for the synthesis of heterocyclic skeleton. In this review, the application
of ILs in the synthesis of different nitrogen-containing heterocyclic compounds has been discussed.
An Overview of Pharmaceutical Care in Type II Diabetes Mellitus
Patients: Current Position and Prospects
Authors: Theivasigamani Kumutha , Palaniappan Senthilkumar 
Published: May 2023

Abstract:
Diabetes mellitus is an ongoing disease that is related to a high mortality rate due to severe
complications. Diabetes mellitus type 2 (DMT2) is a persistent metabolic deficiency and its
prevalence has been increasing consistently worldwide. As a result, it is rapidly turning into a
plague in some parts of the world, and the number of people affected is expected to double in the
following decade due to an increase in the maturing populace, adding to the overall existing importance
for medical service providers, particularly in the underdeveloped nations. Extensive diabetes
care is an intricate task that takes a whole group of medical care experts, including drug specialists,
to provide multidisciplinary care for the patients. The duty of drug experts has changed
significantly in recent years, changing from conventional drug dispensing in the drug store to patient-
centered clinical support services. Upgrading the medication treatment to accomplish better
remedial results without causing drug-related issues has been considered the essential objective of
treatment for diabetic patients. This review discusses the healthcare needs of patients with T2DM,
the current evidence for the role of pharmacists in diabetes care, and insight into the upcoming role
of pharmacists in its management. The advanced role of clinical pharmacists in diabetes control
through drug treatment, diabetes care centers, and diabetes health counselor schooling, is also discussed
in this review.
Analysis of Vitamin C Content and Preferences for Modisco Pudding with
the Addition of Crystal Guava Juice (Psidium guajava L Cultivar Kristal)
Authors: Rohmawati Ninna , Farikha Tera Rizki , Akbar Abdul Azis 
Published: May 2023

Background:
Indonesia has made progress in achieving the target of reducing malnutrition
cases, but 10.2% are still malnourished, according to data from The Global Nutrition Report
2020. Intake of micronutrients, one of which is vitamin C, affects the incidence of malnutrition
cases. Vitamin C has the function of maintaining health through the immune system. One supplementary
feeding program that can overcome cases of malnutrition is Modified Dietetic Skimmed
Milk and Coconut Oil (Modisco). Modisco's reception is not very good, especially for toddlers,
because it is in the form of liquid. Modisco pudding, with the addition of crystal guava juice, aims
to improve the taste and increase the nutritional value of Vitamin C.

Objective:
The objective of the study is to analyze the content of Vitamin C in the preference test of
Modisco pudding with the addition of crystal guava juice at 0%, 15%, 30%, and 45% concentration.

Methods:
This study used a quasi experimental design involving 4 treatments and 3 replications.
The research subjects were 25 panelists of elementary school students.

Results:
The results showed the levels of Vitamin C in various proportions to be significantly different
(p ≤ 0,05). The results of the preference test showed significant differences in the color, aroma,
taste, and texture of the modisco pudding with the addition of crystal guava juice (p ≤ 0,05).

Conclusion:
The results showed that with more addition of crystal guava juice, the level of vitamin
C increased, but the level of preference decreased. The most preferred Modisco pudding was X1
(addition of 15%) with a vitamin C content of 14,4 mg.
Mitochondrial Transplantation and Immune Response of Human Bone
Marrow Mesenchymal Stem Cells for the Therapeutic of Ischemic Stroke
Authors: Liao Yidong , Ming Jiang , Song Wenxue , Chen Guangtang , Cui Junshuan , He Longcai , Wang Zili , Wang Xudong , Xiong Mingsong , Yang Hua , Xu Kaya 
Published: May 2023

Abstract:
Ischemic stroke is the leading cause of death and disability worldwide, with increasing incidence
and mortality, imposing a significant social and economic burden on patients and their families.
However, cerebral vascular occlusion leads to acute loss of neurons and destruction of synaptic structures.
The limited treatment options cannot adequately address intra-neuronal mitochondrial dysfunction due to
stroke. Therefore, stem cell-derived mitochondria transplantation plays an important role in neuronal
protection and recovery after stroke, when combined with the intracranial and extracranial immunoregulatory
effects of stem cell therapy, revealing the mechanism of transferred mitochondria in stem cells in
protecting neurological function among chronic-phase ischemic stroke by affecting the endogenous apoptotic
pathway of neuronal cells. This research elaborated on the mitochondrial dysfunction in neurons
after ischemic stroke, followed by human bone marrow mesenchymal stem cells (hBMSC) rescued damaged
neurons by mitochondrial transfer through tunneling nanotubes (TNTs), and the immunomodulatory
effect of the preferential transfer of stem cells to the spleen when transplanted into the body，which created
an immune environment for nerve repair, as well as improved neurological recovery after the chronic
phase of stroke. This review is expected to provide a novel idea for applying intracranial stem cell transplantation
in chronic-phase ischemic stroke treatment.
Translation of Circular RNAs: Functions of Translated Products and
Related Bioinformatics Approaches
Authors: Hwang Jae Yeon , Kook Tae Lim , Paulus Sydney M. , Park Juw Won 
Published: May 2023

Abstract:
Over the past two decades, studies have discovered a special form of alternative splicing (AS) that produces a circular form of RNA. This stands in contrast to normal AS, which produces a linear form of RNA. Although these circRNAs have garnered considerable attention in the scientific community for their biogenesis and functions, the focus of these studies has been on the regulatory role of circRNAs with the assumption that circRNAs are non-coding. As non-coding RNAs, they may regulate mRNA transcription, tumor initiation, and translation by sponging miRNAs and RNA-binding proteins (RBPs). In addition to these regulatory roles of circRNAs, however, recent studies have provided strong evidence for their translation. The translation of circRNAs is expected to have an important role in promoting cancer cell growth and activating molecular pathways related to cancer development. In some cases, the translation of circRNAs is shown to be efficiently driven by an internal ribosome entry site (IRES). The development of a computational tool for identifying and characterizing the translation of circRNAs using high-throughput sequencing and IRES increases identifiable proteins translated from circRNAs. In turn, it has a substantial impact on helping researchers understand the functional role of proteins derived from circRNAs. New web resources for aggregating, cataloging, and visualizing translational information of circRNAs derived from previous studies have been developed. In this paper, general concepts of circRNA, circRNA biogenesis, translation of circRNA, and existing circRNA tools and databases are summarized to provide new insight into circRNA studies.
A Secure and Energy-efficient Framework for Air Quality Prediction
Using Smart Sensors and ISHO-DCNN
Authors: Singh Vineet , Singh Kamlesh Kumar , Singh Sarvpal 
Published: May 2023

Background:
The World Health Organization (WHO) reported that Air pollution (AP) is
prone to the highest environmental risk and has caused numerous deaths. Polluted air has many constituents
where Particulate Matter (PM) is majorly reported as a global concern. Currently, the most
crucial challenges faced by the globe are the identification and treatment of augmenting AP. The air
pollution level was indicated by the Air Quality Index (AQI). It is affected by the concentrations of
several pollutants in the air. Many pollutants in the air are harmful to human health. Thus, an efficient
prediction system is required. Many security problems and lower classification accuracy are faced by
them even though several prediction systems have been formed. A secure air quality prediction system
(AQPS) centered upon the energy efficiency of smart sensing is proposed in this paper to overcome
these issues. From disparate sensor nodes, the input data is initially amassed in the proposed work.
The gathered data is stored in the temporary server. Next, the air-polluted data of the temporary server
is offered to the AQPS, wherein preprocessing of the input data along with classification is executed.

Methods:
Utilizing the Improved Spotted Hyena Optimization-based Deep Convolution Neural Network
(ISHO-DCNN) algorithm, the classification is executed. Utilizing the Repetitive Data Coding
Based Huffman Encoding (RDC-HE) method, the polluted data attained from the classified output is
compressed and encrypted by employing the American Standard Code for Information Interchange
based Elliptical Curve Cryptography (ASCII-ECC) method.

Results:
Afterward, the encrypted and compressed data is saved in the Cloud Server (CS). Finally, for
notifying about the AP, the decrypted and decompressed data is offered to the Base Stations (BS).

Conclusion:
The proposed work is more effective when analogized to the prevailing methods as denoted
by the experimental outcomes. Higher accuracy of 97.14% and precision of 91.44% were obtained
by the proposed model. Further, lower Encryption Time (ET) and Decryption Time (DT) of
0.565584 sec and 0.005137 sec were obtained by the model.
A Review on the Efficacy of Plant-derived Bio-active Compounds Curcumin
and Aged Garlic Extract in Modulating Cancer and Age-related Diseases
Authors: Das Diptimayee , M Kanchan , Mitra Abhijit , Zaky Mohamed Y. , Pathak Surajit , Banerjee Antara 
Published: May 2023

Abstract:
Aging is a process characterized by accumulating degenerative changes resulting in the
death of an organism. Aging is mediated by various pathways that are directly linked to the individual's
lifespan and are shunted for many age-related diseases. Many strategies for alleviating age-related
diseases have been studied, which can target cells and molecules. Modern drugs such as Metformin,
Rapamycin, and other drugs are used to reduce the effects of age-related diseases. Despite their beneficial
activity, they possess some side effects which can limit their applications, mainly in older adults.
Natural phytochemicals which have anti-aging activities have been studied by many researchers from
a broader aspect and suggested that plant-based compounds can be a possible, direct, and practical
way to treat age-related diseases which has enormous anti-aging activity. Also, studies indicated that
the synergistic action of phytochemicals might enhance the biological effect rather than the individual
or summative effects of natural compounds. Curcumin has an antioxidant property and is an effective
scavenger of reactive oxygen species. Curcumin also has a beneficial role in many age-related diseases
like diabetes, cardiovascular disease, neurological disorder, and cancer. Aged garlic extracts are also
another bioactive component that has high antioxidant properties. Many studies demonstrated aged
garlic extract, which has high antioxidant properties, could play a significant role in anti-aging and
age-related diseases. The synergistic effect of these compounds can decrease the requirement of doses
of a single drug, thus reducing its side effects caused by increased concentration of the single drug.
Entrevista a Ana María Falchetti
Authors: Falchetti Ana María 
Published: May 2023

Gloria Lopera: Buenas tardes, profesora Ana María. Le agradecemos que haya aceptado nuestra invitación a participar en Razón Crítica. Queremos empezar esta entrevista preguntándole sobre su trayectoria académica y profesional: ¿cómo se va encontrando con esa manera de construir una aproximación a los pueblos originarios en los que se tejen la antropología, la arqueología y la historia?
Ana María Falchetti: Gracias. Yo creo que toda la historia empezó en el Museo del Oro. Allá están las décadas de trabajo que son antecedentes de la investigación sobre metalurgia y simbolismo, el tema de mi último libro, y sobre mi investigación sobre la historia de los uwas de la Sierra Nevada del Cocuy.
Methodologies for Monitoring Mental Health on Twitter: Systematic Review
Authors: Di Cara Nina H , Maggio Valerio , Davis Oliver S P , Haworth Claire M A 
Published: May 2023

Background
The use of social media data to predict mental health outcomes has the potential to allow for the continuous monitoring of mental health and well-being and provide timely information that can supplement traditional clinical assessments. However, it is crucial that the methodologies used to create models for this purpose are of high quality from both a mental health and machine learning perspective. Twitter has been a popular choice of social media because of the accessibility of its data, but access to big data sets is not a guarantee of robust results.

Objective
This study aims to review the current methodologies used in the literature for predicting mental health outcomes from Twitter data, with a focus on the quality of the underlying mental health data and the machine learning methods used.

Methods
A systematic search was performed across 6 databases, using keywords related to mental health disorders, algorithms, and social media. In total, 2759 records were screened, of which 164 (5.94%) papers were analyzed. Information about methodologies for data acquisition, preprocessing, model creation, and validation was collected, as well as information about replicability and ethical considerations.

Results
The 164 studies reviewed used 119 primary data sets. There were an additional 8 data sets identified that were not described in enough detail to include, and 6.1% (10/164) of the papers did not describe their data sets at all. Of these 119 data sets, only 16 (13.4%) had access to ground truth data (ie, known characteristics) about the mental health disorders of social media users. The other 86.6% (103/119) of data sets collected data by searching keywords or phrases, which may not be representative of patterns of Twitter use for those with mental health disorders. The annotation of mental health disorders for classification labels was variable, and 57.1% (68/119) of the data sets had no ground truth or clinical input on this annotation. Despite being a common mental health disorder, anxiety received little attention.

Conclusions
The sharing of high-quality ground truth data sets is crucial for the development of trustworthy algorithms that have clinical and research utility. Further collaboration across disciplines and contexts is encouraged to better understand what types of predictions will be useful in supporting the management and identification of mental health disorders. A series of recommendations for researchers in this field and for the wider research community are made, with the aim of enhancing the quality and utility of future outputs.
Al-'Arabiyyah Baina Yadaik Book Speaking Skill Material Based On Common European Framework of Reference (CEFR)
Authors: Samsudin Muhammad Zahid 'Afifarrasyihab Rahimadinullah , Asrori Imam , Mahliatussikah Hanik , Algharibeh Alaualdeen Ahmad Muhammad 
Published: May 2023

This research was conducted with the purpose of describing scope of speaking skill material including theme, functional competency, and types of text exercises and describing level of speaking skill material in Al-‘Arabiyyah Baina Yadaik (ABY) book volume 1 based on the Common European Framework of Reference (CEFR). Approach used in this research is descriptive qualitative approach with the type of library research. The data collection technique used is documentation technique. The analysis technique used is content analysis technique. The result of this research showed that: (a) speaking skill material about theme includes 7 major themes, functional competence includes 5 main functions, and there are 5 types of text exercises in general, (b) ABY 1 book speaking skill materials are at level A1-B1 based on the CEFR.
aulas de educação física como espaço de ensino-aprendizagem das lutas
Authors: Gomes Mariana Simões Pimentel , Scarazzato Juliana , Fabiani Débora Jaqueline Farias 
Published: May 2023

O ensino das lutas, por tradição, é feito por mestres e professores faixas-preta que, em sua maioria, não têm formação em Educação Física (EF) aprendem técnicas da modalidade em suas academias e transmitem para seus alunos tal como aprenderam, muitas vezes sem o devido tratamento pedagógico para os diferentes contextos e personagens destas práticas. Neste artigo, buscamos possibilitar reflexões e discussões acerca do ensino das lutas na escola, oferecendo subsídios teórico-práticos, que foram desenvolvidos baseados em uma experiência, materializada nas aulas de Educação Física (EF) do Ensino Fundamental I de uma escola particular. Nesta pesquisa, de natureza descritiva e propositiva, utilizamos as observações, os registros produzidos e posteriormente as análises feitas a partir desses registros, para organizar objetivos de aprendizagem, entrelaçados com as competências e habilidades da BNCC em um currículo “vivo”, que possa ser ensinado por qualquer professor de EF e não apenas por aqueles com formação em artes marciais e esportes de combate.
A CONSTRUÇÃO DE POLÍTICAS LINGUÍSTICAS EM PERIÓDICOS CIENTÍFICOS
Authors: Ferreira Valmeria Brito Almeida Vilela 
Published: May 2023

Este artigo aborda os discursos que regulam e endossam as políticas linguísticas de periódicos na área da saúde. A pesquisa está fundamenta nos pressupostos teóricos do Círculo de Bakhtin e busca atender os seguintes objetivos i) descrever e analisar os discursos normativos sobre as políticas linguísticas de periódicos científicos; ii) discutir como determinados valores sobre as línguas de publicação científica foram sendo (re) construídos nos discursos dos periódicos investigados. O corpus deste trabalho é composto por editorias e instruções aos autores de periódicos da área médica, publicados entre 1987 e 2020. Os resultados apontam que a busca por visibilidade internacional leva parte dos periódicos a adotar uma política monolíngue, prescrevendo o uso do inglês como a língua franca. Por outro lado, percebem-se políticas editoriais que instituem espaço para o multilinguismo e práticas de escrita científica multilín