bluuebunny/crossref_metadata_2025_split huggingface dataset:
Karakteritik Pasien Dan Kategori Gangguan Penglihatan Pra Operasi Dan Pasca Operasi Katarak Berbasis Komunitas Pusat Mata Nasional Rumah Sakit Mata Cicendo
Authors: Hayyi Indri Nurul , Syumarti  
Published: June 2023

Introduction : The main causes of blindness in the world are cataract. Community-based cataract surgery plays an important role in reducing the burden of cataract blindness.
Objective : To describe patient’s characteristic and visual impairment before and after community-based cataract surgery.
Methods : This is a retrospective descriptive study with secondary data from community-based cataract surgery by the Community Ophthalmology Installation of National Eye Center Cicendo Eye Hospital from January 2019 to December 2020. Visual impairment is divided into four categories based on WHO classification.
Result : There were 3890 patients included. Most of patients were aged 60 to 69 years in 1533 people (39,41%). The most common diagnosis was immature senile cataract in 1826 people (46,94%). Most of patients underwent unilateral cataract surgery using Manual Small Incision Cataract Surgery method and implantation of intraocular lens. The most common category of visual impairment in one eye before surgery was blind, in 3714 eyes (95,48%) and one day after surgery was poor outcome, in 2466 eyes (63,39%). The two-eye blindness before surgery were 1492 people (38,35%) and after surgery were 652 people (16,76%). Sight restoration rate was 26,8%.
Conclusion : Most of the patients were aged 60-69 years. The most common diagnosis is immature senile cataract. The category of one eye visual impairment before surgery was mostly blind, after surgery was moderate visual impairment. There number of blind patients was decrease from 38,35% before surgery to 16,76% after surgery.
Karakteristik Klinis Pasien Ptosis Yang Telah Dilakukan Operasi Di Pusat Mata Nasional Rumah Sakit Mata Cicendo
Authors: Madyaputra Faris Mufid , Kartiwa Raden Angga , Dahlan M Rinaldi , Boesoirie Shanti Fitrianti 
Published: June 2023

Introduction Ptosis is a condition of abnormal upper eyelid position in the primary gaze resulting in a decrease palpebral fissure width. Comprehensive assessments including history taking, physical and thorough eye examination are essential to determine the diagnosis and to decide the most appropriate management of ptosis according to the underlying etiology. The surgical intervention used in ptosis patients is based on the result of the physical examination.
Purpose To describe the clinical characteristic of ptosis patient whom underwent surgical intervention at National Eye Center Cicendo Eye Hospital.
Methods A descriptive retrospective study was conducted from medical records of ptosis patient after surgical intervention at National Eye Center Cicendo Eye Hospital, from January 2018 to December 2020.
Results A total of 91 patients were reviewed. The median age was 19 years old, gender dominated by women. Of these patients, 66 (72.5%) patients had congenital ptosis and unilateral in 80 (87.9%) cases. Results obtained severe ptosis was the highest in ptosis degree as for 72 (79.1%). In total, 58 (63.7%) patients having moderate levator function. Levator resection repair technique was the method of choice in 51 (56%) patients.
Conclusion The most commonly found clinical characteristics in ptosis patients whom underwent surgical intervention was severe degree ptosis and congenital ptosis.
How Not to Do UN Peacekeeping
Authors: de Coning Cedric 
Published: June 2023

Abstract
Looking back over the past seventy-five years of UN peacekeeping, the most enduring question has been: Is peacekeeping effective? Historically, most peacekeeping operations have been. However, peacekeeping is currently suffering from a significant trust deficit. One important factor that differentiates contemporary peacekeeping operations with a stabilization mandate from the historic record is the absence of a viable political or peace process. When security is not directed to serve a peace process, it produces a stabilization dilemma: the more effectively a peace operation protects and achieves stability, the less incentive there is for ruling political elites to find long-term political solutions. This dilemma generates several perverse effects, including prolonging the conflict, trapping operations in place with no exit options, increasing the resilience of armed groups, and embedding peacekeeping in the local political economy. The article identifies five factors that help prevent the stabilization dilemma and influence the effectiveness of peace operations.
The Context of the 2018–20 “Protracted” El Niño Episode: Australian Drought and Terrestrial, Marine, and Ecophysiological Impacts
Authors: Allan Rob , Stone Roger , Gergis Joëlle , Baillie Zak , Heidemann Hanna , Caputi Nick , D’Arrigo Rosanne , Pudmenzky Christa 
Published: June 2023

Abstract
A “protracted” El Niño episode occurred from March–April 2018 to April–May 2020. It was manifested by the interlinked Indo-Pacific influences of two components of El Niño phases. Positive Indian Ocean dipoles (IODs) in 2018 and 2019 suppressed the formation of northwest cloud bands and southern Australia rainfall, and a persistent teleconnection, with enhanced convection generated by positive Niño-4 region sea surface temperature (SST) anomalies and strong subsidence over eastern Australia, exacerbated this Australian drought. As with “classical” El Niño–Southern Oscillation (ENSO) events, which usually last 12–18 months, protracted ENSO episodes, which last for more than 2 yr, show a similar pattern of impacts on society and the environment across the Indo-Pacific domain, and often extend globally. The second half of this study puts the impact of the 2018–20 protracted El Niño episode on both the Australian terrestrial agricultural and marine ecophysiological environments in a broader context. These impacts are often modulated not only by the direct effects of ENSO events and episodes, but by interrelated local to region ocean–atmosphere interactions and synoptic weather patterns. Even though the indices of protracted ENSO episodes are often weaker in magnitude than those of major classical ENSO events, it is the longer duration of the former that poses its own set of problems. Thus, there is an urgent need to investigate the potential to forecast protracted ENSO episodes, particularly when the mid-2020 to current 2022 period has been experiencing a major protracted La Niña episode with near-global impacts.

Significance Statement
The major 2018–20 Australian drought and its terrestrial and marine impacts were caused by a “protracted” El Niño episode, exacerbated by global warming. Indo-Pacific ocean–atmosphere interactions resulted in a persistent positive western Pacific Niño-4 sea surface temperature anomaly during the period 2018–20 and positive Indian Ocean dipoles (IODs) in 2018 and 2019. These suppressed rainfall across eastern Australia and limited northwest Australian cloud band rainfall across southern Australia. Australian agricultural and ecophysiological impacts caused by protracted El Niño–Southern Oscillation (ENSO) episodes permeate, overstress, and expose society, infrastructure, and livelihoods to longer temporal-scale pressures than those experienced during shorter “classical” ENSO events. Thus, there is an urgent need to investigate the potential to forecast protracted ENSO episodes.
Heating of thick continuous glass fiber reinforced thermoplastic plates via embedded metal mesh networks
Authors: Gayton James T , Davids William G , Haller James C , Duffy Jordan , Sheltra Cody , Lopez-Anido Roberto A , Dagher Habib J , Lapp Justin L 
Published: June 2023

A method is proposed to locally heat areas of thick (>25.4 mm) continuous glass fiber reinforced thermoplastic (C-FRTP) composites with embedded wire mesh resistive heating elements. Four test specimens including 10.6 cm wide nichrome mesh heating elements embedded in C-FRTP laminates were fabricated and used for heating trials, showing that the composite can be locally heated to near the thermoplastic forming temperature over its entire thickness in less than 1 hour. The heating trials were simulated using a purpose-built finite difference model to investigate detailed temperature distributions. The simulations show that the internal resistive heating elements are capable of locally increasing the temperature of the composite with negligible effect on the adjacent material. Heating efficiency is between 73% and 77%, with temperature differences in the z-direction at peak temperatures less than 35°C. Temperature uniformity can be improved by longer heating times and more heating elements. The local heating method does not cause deconsolidation of the part. The heating method was also experimentally assessed on a more complex cross-section laminate with varying thickness and a foam core using stainless steel mesh heating elements. Results from the first heating tests were applied to the experimental assessment of the more complex laminate to reduce z-direction temperature differences. Numerical simulation of the heating of the foam core laminate showed a z-direction temperature range of 15.5°C. The results of this study show that embedded resistive heating is a cost-effective and simple method for heating a local portion of a thick fiber reinforced thermoplastic composite.
Prolonged Grief in Times of Lockdown During the COVID-19 Pandemic
Authors: von Blanckenburg Pia , Seifart Carola , Ramaswamy Annette , Berthold Daniel , Volberg Christian 
Published: June 2023

This study aimed to estimate the prevalence of prolonged grief (PG) during the COVID-19 pandemic and to analyze associated variables. 142 family members of patients who died during the lockdown at a hospital were surveyed 6 months after the death. Prolonged grief, depression and anxiety, grief rumination, and loss-related variables were captured. Logistic regression analyses were conducted to detect the associated variables of PG symptoms. Prolonged grief was present in 44.4% of the bereaved. 76.2% of the relatives reported feeling distressed due to visitor restrictions, and the majority of them were unable to bid farewell to their family member at the time of death. Pastoral or psychological care was also lacking. Low education ( p < 0.001), emotional closeness ( p = 0.007), loss of a spouse ( p < 0.001), inability to bid farewell after death ( p = 0.024), feeling of threat due to the pandemic ( p < 0.001), depression ( p = 0.014), and anxiety ( p = 0.028) were significantly associated with prolonged grief.
Effect of External Shocks on the Predictability of Remittance Flows From Developed Countries
Authors: Gnangnon Sèna Kimm 
Published: June 2023

The present analysis has explored the effect of external shocks on the predictability of remittance outflows, by relying on an unbalanced panel of 24 developed countries over the period from 1996 to 2020. The indicator of predictability of remittance outflows for a given country in a given year is the deviation of the remittance outflows (as a share of gross domestic product) from its trend. Results are obtained by means of the within-fixed effects estimator, and indicate that external shocks reduce the predictability of remittance outflows, with a larger negative effect on the positive predictability of these capital outflows than on the negative predictability of these capital outflows. The negative effect of external shocks on the predictability of remittance outflows operates through the economic growth channel, with the magnitude of this negative effect being higher in countries with low economic growth rates. Finally, external shocks reduce the predictability of remittance outflows in countries that experience a decline in migrant inflows. This finding has implications for the economic and development prospects of migrants’ countries of origin. JEL Classification: F24, F43, O11
Challenges and opportunities for improvement when people with an intellectual disability or serious mental illness also need palliative care: A qualitative meta-ethnography
Authors: Ashok Nivedita , Hughes Daniel , Yardley Sarah 
Published: June 2023

Background: People with diagnoses of intellectual disability or serious mental illness have higher mortality rates due to physical comorbidities; better understanding is needed to guide best practice in provision of palliative care for these populations. Aims: To identify multivoiced perspectives, drawn from lived experience of: what works, and what does not, in palliative care for people with intellectual disability or serious mental illness; challenges in, and opportunities to improve, palliative care. Design: A systematically constructed qualitative meta-ethnography. Protocol published (PROSPERO: CRD42021236616). Data sources: MEDLINE, PsychINFO, CINAHL PLUS and Embase used without date limitations. Papers published in English, containing qualitative data on palliative care provision for people with a diagnosis of intellectual disability or serious mental illness were included. Global five-point strength score applied for relevance/quality appraisal. Results: Familiarity (of location, people and/or things) is important for good palliative care. Assumptions and misunderstandings about the role of mental capacity assessment to appropriately involve the patient in decision-making are common. Adapting training for palliative care staff to address concerns and beliefs about mental illness is one of the methods that helps avoid diagnostic overshadowing. Proactive identification of service arrangements to meet needs of persons with personality, psychotic, delusional and bipolar affective disorders will help optimise care. Conclusions: Evidence, including the voices of people with intellectual disability or serious mental illness is urgently needed to guide efforts to improve their access to and experience of palliative care. More evidence is especially needed to understand, develop and implement best practice for people with psychosis, bipolar affective disorder, mania and personality disorder.
Salvianolate Ameliorates Renal Damage Induced by C-BSA in Membranous Nephropathy Rats Through Inhibiting Hypercoagulable State and Alleviating Podocyte Injury
Authors: Chen Wenjun , Tan Jinchuan , Chen Suzhi , Yang Fengwen , Yan Huiming , Duo Huiling , Zhou Huijie 
Published: June 2023

Background Membranous nephropathy (MN), one of the primary pathogenic forms of adult nephrotic syndromes, frequently coexists with hypercoagulability and hyperviscosity. MN is prone to thrombosis, embolism, and other complications, leading to the accelerated occurrence of glomerulosclerosis and renal fibrosis. Therefore, it is particularly important to promote blood circulation and remove stasis through anticoagulant therapy. Salvianolate (SAL) is a Chinese patent anticoagulant commonly used in clinical practice to promote blood circulation and remove blood stasis. SAL plays an important role in alleviating urinary protein and renal pathological damage in MN patients. Objectives In the present study, we aimed to investigate the kidney-protective effect of SAL on MN in a rat model. Materials and Methods The rat model of MN was established by tail vein injection of cationic bovine serum albumin (C-BSA). After the treatment, urinary proteins, hypercoagulable state index (fibrinogen (Fib), D dimer (D-D)), hepatic and renal functions, renal pathology, and podocyte marker proteins were analyzed to explore the renal protective effect of SAL on MN rats and its underlying mechanism. Results In the modeled rats, we discovered a significant rise in urinary protein, a hypercoagulable state, and hypoproteinemia. Additionally, the expressions of Wilms’ tumor protein 1 (WT-1), podocalyxin (PCX), and vascular endothelial growth factor (VEGF) in renal tissues were significantly downregulated, indicating remarkable pathological damage to podocytes and renal tissues in MN rats. The expressions of the above-mentioned indices could be greatly reversed by SAL, which could also regulate the hypercoagulable state and suppress podocyte damage and renal pathological harm. Conclusion Our results suggested that the renal protective effect of SAL on C-BSA-induced MN was related to its ability to inhibit hypercoagulable states, upregulate the expressions of WT-1, PCX, and VEGF in the renal tissue, and repair podocyte injury.
Schisandrin A Suppresses Inflammation in DSS-induced IBD Mice and H2O2-induced MODE-K Cells through Wnt/β-Catenin Signaling
Authors: Xu Hong , Chen Xi , Li Xinlei , Dou Deqiang , Xu Zhili 
Published: June 2023

Background Schisandrin A (SchA) has multiple pharmacological features, and inflammatory bowel disease (IBD) represents a common digestive system disease mainly characterized by inflammation. Objectives To assess the anti-inflammatory effects and the mechanism of SchA in mice with enteritis and in MODE-K cells representing in vivo and in vitro models of inflammation. Materials and Methods DSS-induced IBD mouse models and MODE-K cells (an in vitro model of the intestine) were used to assess the effects of SchA on IBD inflammation and to determine the related signaling pathways. Results Our data showed that SchA exerted anti-inflammatory effects by reducing the general clinical symptoms and the pathological damage to the colonic mucosa in mice with IBD and by promoting the migration of H2O2-induced MODE-K cells, inhibiting apoptotic death, and reducing the release of inflammatory factors. Moreover, SchA downregulated Wnt/β-catenin in both enteritis mice and H2O2-induced cells. Conclusion SchA inhibits inflammation in DSS-induced IBD mice and H2O2-induced MODE-K cells by repressing Wnt/β-catenin signaling.
PD-L1 Expression in Ampullary Adenocarcinoma
Authors: Siddiqui Saima Haleem , Kumari Niraj , Mishra Shravan , Radha Paturu , Mohindra Samir , Singh Rajneesh K , Krishnani Narendra 
Published: June 2023

Introduction Ampullary adenocarcinoma is a rare neoplasm often treated by the complex Whipple's procedure. Several histological factors predict poor prognosis including pancreatobiliary morphology, presence of lymphovascular, perineural invasion and local or distant metastasis. Systemic therapy with gemcitabine, 5-fluorouracil regimens are given with variable benefits. Immunotherapy checkpoint inhibitors have shown beneficial anti-tumor effects in several carcinomas, the most remarkable being in non-small cell lung cancer. Administration of these novel drugs is based on immunohistochemical expression (which may or may not be indicative of response to therapy) along with meticulous decision making by the multidisciplinary team. Immunohistochemistry (IHC) is an effective means of immune marker demonstration and has been used in various tumor types for predictive and prognostic purposes. Methods PD-L1 IHC (clone E1L3N) was applied in 101 cases of ampullary adenocarcinoma. Tumor infiltrating lymphocytes were also evaluated. The immunoreactivity was assessed and categorized into following staining thresholds: <1%, <5%, <10% and ≥10% for tumor cells (membranous and/or cytoplasmic staining pattern), and 5% and 10% cut-offs for immune cells. Results We found that at a 10% cut-off, 73.3% (74/101) patients were men ( P  =  .006) older than 50 years of age ( P < .001) presenting with a tumor measuring <3 cm ( P  =  .001). It was significantly associated with intestinal differentiation ( P  =  .004) and grade 1 tumors ( P  =  .001). Twelve patients presented with recurrence as well ( P  =  .03). Conclusion In the context of ampullary adenocarcinoma, this study highlights the positivity observed with the PD-L1 IHC clone E1L3N at different thresholds, with the particularly stronger associations being evident at a 10% cut-off.
Benchmarking a Center of Excellence in Vascular Surgery: Using Acute Physiology and Chronic Health Evaluation II to Validate Outcomes in a Tertiary Care Institute
Authors: Laczynski DJ , Gallop J , Sicard GA , Sidawy AN , Rowse JW , Lyden SP , Smolock CJ , Kirksey L , Quatromoni JG , Caputo FJ 
Published: June 2023

Objective The Society of Vascular Surgery (SVS) has made it a top priority to implement verification of vascular “centers of excellence”. Our institutional aortic network was established in 2008 in order to standardize care of patients with suspected acute aortic pathology. The implementation and success of this program has been previously reported. We sought to use our experience as a benchmark for which to develop prognostic modeling to quantify clinical status upon admission and help predict outcomes. Our objective was to validate the Acute Physiology and Chronic Health Evaluation (APACHE) II scoring system using a cohort of aortic emergencies transferred by an organized transfer network. Method This was a retrospective, single institution review of patients transferred through an institutional aortic network for acute aortic pathology from 2017-2018. Demographics, comorbidities, aortic diagnosis, APACHE II score, as well as 30-day mortality were recorded. Associations with 30-day mortality were evaluated using two-sample t-tests, ANOVA models, Pearson chi-square tests and Fisher exact tests. Receiver operating characteristic (ROC) curves were fit overall and by pathology to predict 30-day mortality by Apache II total score. Results There were 395 consecutive transfers were identified. The mean age was 64.7 years. Diagnoses included Type A Dissection (n = 134), Type B (n = 81), Aortic Aneurysm (n = 122), and PAU/IMH (n = 27). Mean APACHE II score on arrival was 12. Overall there were 53 deaths (13.4%) in the cohort. Patients that died had significantly higher Apache II total scores (11.3 vs 16.5, P < .001). The area under the receiver operator characteristic (ROC) curve (AUC) was .66 for the full cohort, indicating a poor clinical prediction test. Conclusion APACHE II score is a poor predictor of 30-day mortality in a large transfer network accepting all aortic emergencies. The authors believe further refining a prognostic model for diverse population will not only help in predicting outcomes but to objectively quantify illness severity in order to have a basis for comparison among institutions and verification of “centers of excellence”.