bluuebunny/crossref_metadata_2025_split huggingface dataset:
The preliminary development and psychometric properties of the Psychotherapy Side Effects Scale
Authors: Fazhan Chen , Liang Liu , Xudong Zhao , Qiang Feng , Congcong Ge , Yunhan Zhao 
Published: January 2023

AbstractBackgroundSide effects in psychotherapy are common and have a negative impact on patients or clients. However, effective evaluation tools are still lacking and have not been fully studied. The present study aims to develop a scale with good reliability and validity to measure the side effects of psychotherapy.MethodsThe 25 items in the Psychotherapy Side Effects Scale (PSES) were condensed and distributed to 420 subjects online to test its psychometric properties.ResultsThe internal consistency of the PSES was satisfactory to excellent (Cronbach's ɑ coefficient was .95, and the Guttman split‐half coefficient was 0.88). A statistically significant negative correlation between the satisfaction score and the total score of the PSES was shown (r = −0.51, p < .001). The PSES could effectively discriminate between two groups with and without side effects (F = 250.95, p < .001) and was able to predict the occurrence of side effects in psychotherapy with an area under curve of 0.932 and a 95% confidence interval of 0.900–0.964 (p < .001). A cutoff was set at 36 points in total PSES score, from which the maximum Youden's index (= 0.72) could be obtained. The positive rate of the PSES was 24% (101/420).ConclusionThe PSES showed good internal consistency, content validity, concurrent validity, discriminant validity and predictive validity in evaluating and identifying side effects in psychotherapy. More advanced reliability testing methods and structural validity testing for PESE need to be practiced in the future to better serve clinical practice.
Characterization of the gene signature correlated with favorable response to chemoradiotherapy in rectal cancer: A hypothesis‐generating study
Authors: Jeon Seung Hyuck , Chie Eui Kyu 
Published: January 2023

AbstractPurposeThis study aimed to define the gene signature associated with response to neoadjuvant chemoradiotherapy (nCRT), or chemoradiosensitivity (CRS) signature, in rectal cancer, and investigate the correlation between the CRS signature and characteristics of tumor.Materials and MethodsThree public microarray datasets of pre‐nCRT rectal cancer were used to discover and validate the CRS signature, and the pathway analysis of the CRS signature was performed. Patients in The Cancer Genome Atlas (TCGA) dataset were stratified according to the CRS signature enrichment score, and mutational profile and proportions of infiltrated immune cells were compared.ResultsIn the discovery dataset (GSE53781), 95 genes were upregulated in complete responders compared to non‐complete responders and defined as the CRS signature. Pathways regarding DNA replication and repair processes as well as inflammatory response were enriched in the CRS signature. In the validation datasets (GSE35452 and GSE45404), patients with favorable response to nCRT exhibited higher enrichment score of the CRS. In TCGA‐READ cohort, patients with high CRS signature harbored KRAS mutation in lower frequency than those with low CRS signature. In addition, proportions of proinflammatory immune cells were higher, but proportion of immunosuppressive M2 macrophages was lower in patients with high CRS signature than those with low CRS signature.ConclusionsThe current integrative bioinformatic analysis suggests the CRS signature and showed that the CRS signature is associated with dissimilar mutational profile and increased immune response. The discovered CRS signature and related characteristics may serve as candidate of stratification factor in upcoming studies for rectal cancer.
Autologous menisci–cruciate ligament composite as a flap for soft tissue reconstruction following malignant bone tumor resection around the knee
Authors: Xu Yu , Li Yan , Fu Yiwei , Wang Bo , Lin Tiao , Zou Changye , Huang Gang , Shen Jingnan , Yin Junqiang 
Published: January 2023

AbstractBackgroundDespite significant improvements in oncological treatment, the management of soft tissue defects following malignant tumor resection remains challenging. We investigated whether autologous menisci and cruciate ligament, which are traditionally discarded, can be recycled as a supplemental flap in repairing soft tissue defects following malignant bone tumor resection and endoprosthetic reconstruction around the knee.MethodsFour knee specimens were dissected to provide a basis for the design of the menisci–cruciate ligament composite. Then, 40 patients with bone malignancies around the knee were enrolled and underwent reconstruction with free or vascularized composite following malignant tumor resection. The clinical, radiographic, and functional outcomes of this technique were evaluated in >1‐year follow‐up in each patient and compared with 87 patients who suffered from bone malignancies around the knee and were treated by limb salvage but without composite at our center over the same period. During the follow‐up, a composite from one patient who underwent secondary amputation was retrieved and examined for in vivo remodeling.ResultsFourteen patients were treated with vascularized composite transfer (10 distal femurs and 4 proximal tibias) and 26 patients with free composite transfer (19 distal femurs and 7 proximal tibias). The composite can be used to cover the area of soft tissue defect from 22 to 48.38 cm2 (34.67 ± 6.48 cm2). With contrast‐enhanced ultrasound, peripheral rim healing and dotted blood flow signal at the side of anastomosis were detected on a patient 16 months after free composite transfer. Gross macroscopic remodeling and histopathologic analysis of a retrieved composite also indicated good healing with surrounding tissues and living cells in the composite. The complications and oncologic outcomes were comparable between study and control cohorts, but better Musculoskeletal Tumor Society (MSTS) score for patients reconstructed with composite (26.68 vs. 25.66, p = 0.004). Of note, MSTS score was higher for patients reconstructed with composite at distal femur subdivision compared with the same subdivision in the control cohort (26.97 vs. 25.90, p = 0.009). No statically significant difference was noted in complications, oncologic, and functional outcomes for patients reconstructed with free or vascularized composite.ConclusionAutogenous menisci–cruciate ligament composite is an alternative option for soft tissue reconstruction. Either vascularized or free composite can be applied, depending on the size and localization of the defect.
Different situations of identifying second primary malignant tumors in lymphoma patients with synchronous solid tumors
Authors: Gao Hongye , Wang Xiaogan , Lai Yumei , Zhang Chen , Mi Lan , Ji Xinqiang , Wang Xiaopei , Song Yuqin , Zhu Jun , Liu Weiping 
Published: January 2023

AbstractBackgroundTo our knowledge, the different situations of identifying second primary malignant tumors (SPMTs) in lymphoma patients with synchronous solid tumors remain to be comprehensively investigated.MethodsWe retrospectively collected information pertaining to lymphoma patients with synchronous solid tumors (diagnosed within 6 months) at Peking University Cancer Hospital & Institute between 2009 and 2019. The non‐parametric Aalen–Johansen estimator was applied to calculate cumulative incidence function in the competing risk model. Furthermore, propensity score‐matched analysis was performed to compare survival differences in lymphoma patients with or without synchronous solid tumors.ResultsThirty‐eight patients were enrolled. There were three situations of identifying SPMTs. First, in 15 patients (39.5%), SPMTs were identified before the initiation of any treatment. Among them, priority was given to anti‐lymphoma treatment in case of only three patients. Second, in 17 patients (44.7%), SPMTs were unexpectedly detected on surgical specimen assessment; of them, 13 received anti‐lymphoma treatment after surgery. Third, in six patients (15.8%), SPMTs were identified after the outset of treatment for the primary tumor; in this population, three of four patients with lymphoma switched toward the treatment plan for SPMTs. The 5‐year overall survival was 58.7%. The cumulative incidence function within 5 years was 26.6% for lymphoma and 14.7% for other solid tumors. The early identification of SPMTs was associated with better outcomes (p = 0.048). After balancing the baseline characteristics, no differences in survival were observed between lymphoma patients with and without synchronous solid tumors (p = 0.664).ConclusionsThis is the first study to present the different situations of identifying SPMTs in lymphoma patients with synchronous solid tumors. In only <50% patients, SPMTs were identifiable at baseline. SPMT identification at different situations may make it difficult to choose the optimal therapeutic option, which may consequently impact patient survival.
Quality Data from Messy Spectra: How Isometric Points Increase Information Content in Highly Overlapping Spectra
Authors: Kaspar Felix 
Published: January 2023

AbstractSpectroscopic techniques are immensely useful for obtaining information about chemical transformations while they are happening. However, such data are often messy, and it is challenging to extract reliable information from them without careful calibrations or internal standards. This short introductory review discusses how isometric points (points in a spectrum where the signal intensity remains constant throughout the progress of a chemical transformation) can be used to derive high‐quality data from messy spectra. Such analyses are helpful in a variety of (bio‐)chemical settings, as selected case studies demonstrate.
N‐doped Nanocarbon Inserted NiCo‐LDH Nanoplates on NF with High OER/ORR Performances for Zinc‐Air Battery
Authors: Jia Zhe , Shang Jiayin , Xue Kaijing , Yang Xi , Wang Sumin , Xu Changhua , Wang Qiguan 
Published: January 2023

AbstractHerein, a high performance bifunctional catalyst was prepared by inserting N‐doped nanomaterials into Ni−Co layered dihydroxides (NiCo‐LDH) nanoplates for high performance zinc‐air battery. By using self‐assembly of perylenetetracarboxylic dianhydride and dicyandiamide in the hydrothermal condition, a nitrogen‐containing super thin carbonaceous nanosheet is achieved after calcination. Then NCM inserted NiCo‐LDH nanoplates attached to nickel foam (NiCo‐LDH/NCM@NF) are synthesized by in‐situ production of NiCo‐LDH species on NCM wrapped NF. The specific NCM improves the conductivity, electroactive surface area and the ORR/OER bifunctional activity of NiCo‐LDH nanoplates. In addition, benefited from the formed rich oxygen vacancies, NiCo‐LDH/NCM@NF delivers the low OER overpotential (352 mV at 50 mA cm−2) and boosted ORR performance with a half‐wave potential of 0.765 V vs RHE. As the air cathode, the fabricated ZAB devices show a satisfactory capacity of 685 mAh g−1 and the energy density of 158 mW cm−2.
Plugging the 3MC Sink in RuII‐Based Photocatalysts
Authors: Shillito Georgina E. , Rau Sven , Kupfer Stephan 
Published: January 2023

AbstractQuantum chemical methods have been utilised to explore the kinetics and thermodynamics of a prominent charge recombination pathway in a series of RuII based molecular photocatalysts. Selective tuning of the RuII coordination sphere, replacing the tbbpy ligands of the hydrogen evolving parent photocatalyst with electron rich, biimidazole based ligands, promotes unidirectional charge transfer towards the bridging ligand during initial photoexcitation. These electronic effects are also significant in the triplet manifold, where the predicted rate of the undesired deactivation process from the 3MLCT state on the bridging ligand to a 3MC state on the ruthenium centre, is decreased relative to the parent complex, by 1–2 orders of magnitude, alongside a decrease in electronic coupling. This design methodology could be utilised to promote targeted (light‐driven) electron transfer pathways, as well as to potentially reduce 3MC deactivation pathways in commonly used polypyridyl‐based RuII photocentres, thus enhancing the quantum efficiency of light driven catalysis.
Improved Catalytic Performance of Direct Dehydrogenation of Ethylbenzene by Creating Boron Defects on Phosphorus‐doped Boron Nitride
Authors: Liu Yuwei , Liu Hongyang , Luo Lukai , Lin Baining , Zhou Yonghua , Wang Hanqing , Wang Ping , Mao Yu 
Published: January 2023

AbstractPhosphorus‐doped boron nitride (PBN) has been confirmed as an effective metal‐free catalyst for the direct dehydrogenation (DDH) of ethylbenzene to styrene. In this paper, we further used barbituric acid as co‐reactant sources to create B defects in both PBN and mesoporous PBN (m‐PBN) materials. The XPS, N2 adsorption‐desorption, UV‐vis DRS, EPR, 11B SS NMR characterizations indicated both the electronic and pore structures of the catalyst with B defects were adjusted. Except for the improvement of mass transfer caused by B defects, DFT calculations showed the increase of electron density in B defects areas could enhance the breaking of C−H in ethylbenzene and the bond‐forming of H−H, which was acted to improve the catalytic activity. The m‐PBN with B defects delivered the styrene production rate of 22.54 mmolST g−1 h−1 and stably run 300 h when in‐situ grown on Al2O3, proving that defect tuning strategy is useful to construct efficient catalysts for styrene production.
Chiral Silanols: Strategies and Tactics for Their Synthesis
Authors: Gao Jihui , He Chuan 
Published: January 2023

AbstractSilanols are valuable and important compounds, which have found widespread applications in the field of materials science, synthetic chemistry, and medicinal chemistry. Although a handful of approaches have been developed for the synthesis of various silanols, access to enantioenriched silicon‐stereogenic silanols remains underdeveloped. This Concept article intends to summarize and highlight recent advances in the construction of silicon‐stereogenic silanols and endeavors to encourage further research in this area.
High Content Imaging and Quantification of Microglia Phagocytosis In Vitro
Authors: McPherson Christopher A. , Kelly‐Rajan Kiran , Lefebvre d'Hellencourt Christian , Harry G. Jean 
Published: January 2023

AbstractMicroglia function as the tissue‐specific resident macrophages of the nervous system, performing immune and non‐immune functions. These functions are critical to development and to maintain homeostasis in the nervous system throughout the lifespan, and during brain injury or disease. One method by which microglia maintain homeostasis is phagocytosis of aberrant proteins, extracellular debris, synapses, or apoptotic cells. Phagocytic function can be changed by environmental or genetic risk factors that affect microglia. These protocols present a rapid and simple in vitro high‐content imaging protocol for studying phagocytosis in the murine microglia BV‐2 cell line. High‐content imaging and analysis enable versatility of the assay, which can be used to test multiple experimental conditions, or as a screening tool. © 2023 Wiley Periodicals LLC. This article has been contributed to by U.S. Government employees and their work is in the public domain in the USA.Basic Protocol 1: Phagocytosis of fluorescently labeled particlesBasic Protocol 2: Examining modifications to phagocytosis by test substancesBasic Protocol 3: High content imaging and analysis of phagocytic cells
A power management strategy for a grid‐connected multi‐energy storage resources with a multiport converter
Authors: Tarassodi Pouya , Adabi Jafar , Rezanejad Mohammad 
Published: January 2023

SummaryThis paper presents a power management strategy to control a multiport converter as an interface among a three‐phase power grid, a renewable energy source (RES), and two energy storage resources (ESRs). The ESRs include electric energy storage (EES) and electric vehicle (EV). With the expansion of the use of EVs, batteries from EVs can be used as energy storage and support the integrated RES‐based electricity systems. EES and EV differ in availability, capacity, and charge/discharge rates. The multiport converter has a simple structure and reduced number of elements that allows simultaneous and independent use of resources. Two bidirectional DC ports enable two‐way power flow for ESRs. A two‐level power management system (TLPMS) is presented to deal with controlling battery charging, Vehicle‐to‐Grid (V2G) operation, and RES and power grid utilization. This way, TLPMS changes the case studies (CSs) based on the availability of EV and photovoltaic (PV) as well as batteries' state‐of‐charge (SOC). The performance of the proposed TLPMS has been evaluated by simulation results and experimental tests. The results show the fast and robust performance of the proposed TLPMS. So that the current on the power grid side, under consecutive changes in the CSs, achieves a steady state during a cycle (20 ms). Also, the speed of DC sources in achieving their reference values is high, which indicates the outstanding features of the proposed system.
What determines plant species diversity along the Modern Silk Road in the east?
Authors: Liu Yanlei , Xu Chao , Dong Wenpan , Chen Xun , Zhang Wen , Sun Yuzhe , Wang Guohong , Wang Yufei , Zhou Shiliang 
Published: January 2023

AbstractAs primary producers, plants provide food, oxygen, and other resources for global ecosystems, and should therefore be given priority in biodiversity protection. Most biodiversity research focuses on biodiversity hotspots, while biodiversity coldspots, such as deserts, are largely ignored. We propose that the factors shaping plant species diversity differ between biodiversity hot spots and cold spots, especially for desert ecosystems. To test this hypothesis, we investigated plant species diversity along the Modern Silk Road in the Northwest China desert, an area characterized by low precipitation, scarce vegetation, a limited number of species, and variable human activities. Surface soil was sampled from 144 plots, environmental DNA (eDNA) was extracted from soil samples, and seed plant species were identified using DNA metabarcoding technology. A total of 671 seed plant species were detected, which was more diverse than indicated by plot survey data. Plant species diversity gradually decreased from east to west along the Silk Road. In this area, temperature determines plant species diversity more than precipitation. Additionally, human activity has altered plant species diversity by introducing crops and invasive plants and eliminating environmentally adapted indigenous plants. Our results demonstrate the potential of eDNA metabarcoding technology for plant species diversity surveying. Desert plants have adapted to dry environments by relying on underground water or utilizing occasional rainfall as ephemerals, which are often not visible during surface surveys because of their short aboveground life cycle but can be detected with eDNA metabarcoding technology. Groundwater maintenance and human activity control are recommended for plant species diversity conservation and desertification control.
Perceptions on pregnancy and parenthood among program directors in pediatric dentistry
Authors: Canares Glenn , Rashed Heba , El‐Sayed Omar 
Published: January 2023

AbstractPurposeThis cross‐sectional study assessed the perceptions of pediatric dental residency program directors (PDs) regarding policies and attitudes on pregnancy and parenthood during residency training.MethodsA 28‐item electronic survey was administered to PDs of pediatric dental residencies in the United States. Statistical tests were performed. Variables were reported as counts (percentages) and compared using Fischer's exact test and chi‐squared tests at a significance level of 0.05.ResultsForty‐two of the 97 PDs completed the survey for 43% response rate. Almost all programs had a formal maternal leave policy, but perceptions and policies varied regarding the effects of both pregnancy and parenthood on residents during training. Chi‐square results compared if parenthood had a negative impact on the well‐being a female trainee versus a male trainee had a p‐value < .05.ConclusionsThere appeared to be a lack of national uniformity regarding program policies on parental leave. Most PDs perceived having a child during residency had at least one negative effect on their female residents. Finally, PDs were likely to perceive parenthood to adversely impact the well‐being and work of female trainees more so than their male counterparts.
Proof of a conjecture of Plummer and Zha
Authors: Chudnovsky Maria , Seymour Paul 
Published: January 2023

AbstractSay a graph is a pentagraph if every cycle has length at least five, and every induced cycle of odd length has length five. Robertson proposed the conjecture that the Petersen graph is the only internally 4‐connected pentagraph, but this was disproved by Plummer and Zha in 2014. Plummer and Zha conjectured that every internally 4‐connected pentagraph is three‐colourable. We prove this: indeed, we will prove that every pentagraph is three‐colourable.
A leadless pacemaker in the real‐world setting: Patient profile and performance over time
Authors: Roberts Paul R. , Clémenty Nicolas , Mondoly Pierre , Winter Stefan , Bordachar Pierre , Sharman David , Jung Werner , Eschalier Romain , Theis Cathrin , Defaye Pascal , Anderson Christopher , Pol Aimée , Butler Kiah , Garweg Christophe 
Published: January 2023

AbstractBackgroundWhile prior Micra trials demonstrated a high implant success rate and favorable safety and efficacy results, changes in implant populations and safety over time is not well studied. The objective of this analysis was to report the performance of Micra in European and Middle Eastern patients and compare to the Micra Investigational Device Exemption (IDE) and Micra Post Approval Registry (PAR) studies.MethodsThe prospective, single‐arm Micra Acute Performance European and Middle Eastern (MAP EMEA) registry was designed to further study the performance of Micra in patients from EMEA. The primary endpoint was to characterize acute (30‐day) major complications. Electrical performance was analyzed. The major complication rate through 12 months was compared with the IDE and PAR studies.ResultsThe MAP EMEA cohort (n = 928 patients) had an implant success rate of 99.9% and were followed for an average of 9.7 ± 6.5 months. Compared to prior studies, MAP EMEA patients were more likely to have undergone dialysis and have a condition which precluded the use of a transvenous pacemaker (p < .001). Within 30 days of implantation, the MAP EMEA cohort had a major complication rate of 2.59%. Mean pacing thresholds were low and stable through 12 months (0.61 ± 0.40 V at 0.24 ms at implant and 12 months). Through 12 months post‐implantation, the major complication rate for MAP EMEA was not significantly different from IDE (p = .56) or PAR (p = .79).ConclusionDespite patient differences over time, the Micra leadless pacemaker was implanted with a high success rate and low complication rate, in‐line with prior reports.