bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quantitative proteomic analysis of local and systemic extracellular vesicles during Eimeria falciformis infectious cycle in the host
Authors: Olajide Joshua Seun , Qu Zigang , Yang Shunli , Yang Bin , Xu Xiao , Wang Jing , Cai Jianping 
Published: September 2023

Abstract
Background
Extracellular vesicles (EVs) are membranous structures that are formed during pathophysiology, host-parasite interactions and parasite motility. Typically, apicomplexan-infected host cells secrete EVs which traverse local and systemic strata of the host as the parasites develop.

Methods
Extracellular vesicles were isolated from the caecum and serum of Eimeria falciformis-infected mice during oocyst ingestion (0 h post-infection [0 hpi]), merozont stages 1 and 2 (68 and 116 hpi), oocyst shedding (7 days post-infection [7 dpi]) and host recovery (10 dpi) and subsequently characterized and profiled by tandem mass tag (TMT).

Results
With the progression of E. falciformis life stages, subpopulation of EVs bearing EV biomarkers, including CD9, CD82, heat shock protein 70 (HSP70) and major histocompatibility complex (MHC) molecules, increased. A total of 860 and 1024 differentially expressed proteins were identified in serum EVs (sEVs) and caecum EVs (cEVs), respectively. Identified immune-related molecules (such as cytokines, receptors, immunoglobins, complements, hormones, inflammasomes), ion exchange and cell death-associated proteins were significantly expressed, at least during the E. falciformis first and second merozont stages. Bioinformatics assessment indicated that sEV proteins were at all time points implicated in antigen processing and presentation as well as natural killer cell-mediated cytotoxicity (68 hpi), complement activation/blood coagulation (116 hpi/10 dpi) and catabolic activities (7 dpi). In contrast, cEV proteins were involved in catabolic process, ion transport and antigen presentation (68 and 116 hpi). Host response to E. falciformis infection was similar to intestinal bacterium at 7 dpi and cell adhesion and intercellular protein transport at 10 dpi. In both systems, ferroptosis and necroptosis were common across the parasite’s infectious cycle while apoptosis occurred at 68 hpi.

Conclusion
The proteomic data indicate that E. falciformis infection co-opts cellular and humoral responses through EV secretions, and that, host cell death and ionic imbalance are associated with E. falciformis infection. This study offers additional insight into host-parasite interactions and host regulatory EV proteins as potential disease indicators or diagnostic molecules.

Graphical Abstract
Dynamics of protozoal excretion in the faeces of calves during the first 28 days after arrival at the fattening farm indicate infection before regrouping and show poor temporal correlation with diarrhoea
Authors: Bauer Jessica , Kaske Martin , Oehm Andreas , Schnyder Manuela 
Published: September 2023

Abstract
Background
Calves in dairy cattle production in Switzerland are transported to a fattening farm at the age of 3–5 weeks, and frequently suffer from diarrhoea within the first 14 days after arrival. To characterise the role of intestinal protozoa in this, we investigated the excretion dynamics of Eimeria, Cryptosporidium and Giardia during the first 28 days after the arrival and regrouping of calves at fattening farms.

Methods
A total of 610 faecal samples from 122 calves (mean age 37.3 days; mean body weight 79.8 kg) were collected on seven different fattening farms during the first 28 days after the arrival and regrouping of the animals. The farms were visited between January and April (cold season; n = 4) and between June and August (warm season; n = 3). The samples were collected rectally on days 1, 4, 7, 14 and 28, assessed for consistency, and analysed using the McMaster method for quantitative determination of the number of Eimeria oocysts per gram of faeces (OPG), flotation for morphological differentiation of the unsporulated Eimeria oocysts, a concentration method for the semi-quantitative determination of Giardia cysts, and modified Ziehl–Neelsen staining for semi-quantitative determination of Cryptosporidium oocysts.

Results
Overall, 50.8% (62/122) of the animals had diarrhoea during the study period. However, the faecal excretion of protozoal pathogens was neither associated with diarrhoea nor with body weight gain of the animals. Altogether, 90.2% (110/122) of the calves were Eimeria positive. Eimeria zuernii was excreted by 51 (41.8%) and Eimeria bovis by 68 (55.7%) animals. In the warm season more animals tested positive for Eimeria and OPGs were higher than in the cold season. There was no correlation between the age of the calves and the OPG values. Overall, 64.8% (79/122) of the calves excreted Eimeria oocysts within the first 7 days, indicating that they had been infected with the parasite on the dairy farm of origin. Eighty-nine calves (73.0%) excreted Giardia cysts, with more positive animals in the cold (80.3%) compared with the warm season (64.3%). Only Giardia duodenalis assemblage E was identified. Cryptosporidium oocysts were microscopically detected in 14 animals (11.5%) on five farms. Cryptosporidium spp. were present in a total of 12 animals, i.e. Cryptosporidium parvum in nine, Cryptosporidium ryanae in two, and Cryptosporidium bovis in one animal.

Conclusions
A better understanding of the temporal dynamics of protozoal infections in calves is helpful for the implementation of appropriate measures to protect the health of these animals at a critical phase in their lives. Our results indicate that factors other than those examined in the present study contributed to the onset of diarrhoea in the calves.

Graphical abstract
Hard Labor and Sweet Delights
Authors: Highfill Juli 
Published: September 2023

Abstract
Luisa Carnés’s novel Tea Rooms: Mujeres obreras (1934) recounts the corporeal and sensory experience of workers in a pastelería, capturing their hunger and fatigue amid the smells of freshly baked pastries. These working women are thus inserted into economic space, defined as the production, distribution, and consumption of the material goods that sustain life and give pleasure. The novel makes palpable their desire to enjoy the consumer products that surround them—whether in the tea room, in nearby shops, or in the cinema across the street—pleasurable goods that remain beyond their means. In the musical comedy El bailarín y el trabajador (1936), a ruined señorito, formerly a ballroom dancer, finds himself relegated to working in a cookie factory. As he redirects his bodily exertion from nonproductive to productive labor, he sings of the working life as “dulce y sabrosa” (sweet and flavorful). Based on a play by Jacinto Benavente (1925), and repurposed in the era of the Popular Front, the film attempts to ease class conflict by celebrating the working life and asserting interclass harmony, thereby appealing to viewers on both the left and right. But despite its bourgeois perspective, the striking shots of the machinery, with the masa (dough) emerging from the cylinders—flattened, stamped, and cut into cookies—clearly suggest the masses in the process of organizing and coming to consciousness. And juxtaposed with these factory scenes are segments showing the glamorous, “sweet” life of the idle rich. Both the novel, with its Marxist critique, and the film, with its bourgeois message, mobilize affects by deploying the material metaphors of foodstuffs—sweets, in this case—that provide not so much sustenance as pleasure. These two works thus foreground in quite different ways the notion of “communal luxury,” the right of workers to beauty, to pleasure, and to a life of the mind.
Skin to Skin
Authors: Viestenz William 
Published: September 2023

AbstractThis article analyzes two Catalan novels, Albert Sánchez Piñol’s Victus: Barcelona 1714 (2012) and Martí Domínguez’s L’esperit del temps (2019), in light of the concept of immunity developed by the Italian theorist Roberto Esposito. It is argued that the two works share an affinity by demonstrating the material relevance of Esposito’s concepts, especially with reference to the skin as the basis for biopolitics. Victus links the rending of skin to textuality but simultaneously uses the breaking open of the body to highlight community as an assemblage of diverse material actors and agents. L’esperit del temps situates Nazi thanatopolitics at the intersection of biology and law, emphasizing how a politics of death relies on what kinds of matter, such as the phenotype of skin, are fetishized, pathologized, and subjected to human-centered techniques of power. Domínguez returns to the Second World War to comment on more contemporary concerns regarding bioethics and the increasingly mainstream presence of extremist politics in Europe. Opening the discussion with the reflections on skin of Donna Haraway and Jean-Luc Nancy, the article closes by engaging with Haraway’s work on companionship and the “illicit fusion” of beings, particularly in the historical period referred to as the “Chthulucene,” in which kinship and multispecies assemblages are viewed as tools for survival.
Picturing Herself in Africa
Authors: Johnson Grace L. Sanders 
Published: September 2023

Abstract
This essay explores the relationship between imaging, archival cataloging, and African diasporic belonging through the developed and undeveloped photography of Haitian anthropologist Suzanne Comhaire-Sylvain. Using her family correspondences and research on folklore to contextualize her image-based archive on Haiti, the Belgian Congo, and Nigeria, the author proposes that Comhaire-Sylvain’s visual catalog is rendered legible through her undeveloped images taken in Africa. Tracing Comhaire-Sylvain’s contortions in front of and behind the camera, the author shows that her undeveloped and unpublished imaging practices of play and experimentation exemplify a medium of scholarly and personal reflexivity that troubled the authority of her professional research practice and enlivened the range of her diasporic expression. With particular attention given to photos taken during her time in the Belgian Congo between 1943 and 1945 and her long-stay return to Haiti in 1957, the author argues that Comhaire-Sylvain’s imaging catalog is most provocatively read as an assemblage bound by her use of folklore as a unique technology for crafting meaning between overlapping sites of diasporic belonging and intellectual inquiry.
Synthesis, Characterization, and Application of a Cyclic Stilbene Derivative with Simultaneous Two-photon Absorption Character
Authors: Santiko Erik Budi , Babu Shrestha Binod , Zhang Fan , Wu Cheng-Lin , Lin Tzu-Chau , Abe Manabu 
Published: September 2023

Abstract
A new cyclic stilbene derivative, 6-(4-(diphenylamino)phenyl)-N,N-diphenyl-7,8-dihydronaphthalen-2-amine (D2PDN), featuring a quadrupolar system having electron-donating substituents (NPh2), was synthesized and characterized in this study. The fluorescence quantum yield was 89% (under air) and 99% (under argon) in toluene. The two-photon (2P) cross-section was determined to be 166 GM at 700 nm using 2P-excitation fluorescence method. The 2P-responsive chromophore in near-infrared region has reversible oxidation signals at 0.17, 0.28, and 0.53 V vs Fc0/Fc+. Compound D2PDN, E*ox = −2.83 V, was found to be a simultaneous 2P-responsive photoredox catalyst.
Blind Dynamic Resource Allocation in Closed Networks via Mirror Backpressure
Authors: Kanoria Yash , Qian Pengyu 
Published: September 2023

We study the problem of maximizing payoff generated over a period of time in a general class of closed queueing networks with a finite, fixed number of supply units that circulate in the system. Demand arrives stochastically, and serving a demand unit (customer) causes a supply unit to relocate from the “origin” to the “destination” of the customer. The key challenge is to manage the distribution of supply in the network. We consider general controls including customer entry control, pricing, and assignment. Motivating applications include shared transportation platforms and scrip systems. Inspired by the mirror descent algorithm for optimization and the backpressure policy for network control, we introduce a rich family of mirror backpressure (MBP) control policies. The MBP policies are simple and practical and crucially do not need any statistical knowledge of the demand (customer) arrival rates (these rates are permitted to vary in time). Under mild conditions, we propose MBP policies that are provably near optimal. Specifically, our policies lose at most [Formula: see text] payoff per customer relative to the optimal policy that knows the demand arrival rates, where K is the number of supply units, T is the total number of customers over the time horizon, and η is the demand process’ average rate of change per customer arrival. An adaptation of MBP is found to perform well in numerical experiments based on data from NYC Cab. This paper was accepted by Gabriel Weintraub, revenue management and market analytics. Funding: Y. Kanoria was supported by the National Science Foundation’s Division of Civil, Mechanical, and Manufacturing Innovation [Grant CMMI-1653477]. Supplemental Material: The data files and online appendices are available at https://doi.org/10.1287/mnsc.2023.4934 .
The effect of implementing the COMFORT communication model on communication skills of nursing students
Authors: Mahdiabadi Farzad Reisi , Mirzaei Samaneh , Entezari Ahmad , Nasiriani Khadijeh 
Published: September 2023

Background: Effective communication as a key component of palliative care requires sufficient knowledge and experience to make nursing interventions successful. Aim: This quasi-experimental study was conducted to determine the effectiveness of the COMFORT communication model as an intervention to improve student nurses’ communication skills while they are under clinical training in specialist palliative care inpatient units. Methods: The population sample included 86 student nurses who were randomly assigned into two groups of 40. The intervention group received training on communication skills using the COMFORT communication model. Nine lectures were delivered online or offline; the lectures lasted between 25 to 60 minutes. The control group received the conventional educational programme about communication with patients and families, according to the curriculum of the bachelor's degree in nursing. Data were collected using the Communication Skills Questionnaire and Communication Skills Attitude Scale and analysed using IBM® SPSS® Statistics 22.0. Results: The findings showed that, after the implementation of COMFORT communication model, there was a statistically significant difference in communication skills between the intervention group (122.95±9.36) and the control group (110.1±8.92). There was also a significant difference in attitudes toward communication skills between the intervention group (90.25±8.86) and the control group (90.85±9.15) (P=0.0001). The findings of the study revealed that the COMFORT Communication model created significant statistical differences in the student's attitude, knowledge and communication skills. Conclusion: Novice nurses sometimes struggle with the level of communication skills needed when caring for patients with an end-stage illness. The implementation of the COMFORT communication model significantly improved communication skills and attitudes toward communication. Due to the need to establish effective communication as the core of nursing practice, the implementation of this training programme is recommended for students and qualified nurses, particularly when providing palliative care.
Caring ability and its related factors in the family caregivers of patients with cancer
Authors: Rassouli Maryam , Beiranvand Samira , Karami Maryam , Dorcheh Azam Eshaghian , Ashrafizadeh Hadis 
Published: September 2023

Background: Caregivers of cancer patients experience a variety of challenges caused by the prolonged burden of care. Many of these caregivers do not have the necessary knowledge, skills and caring ability to fulfil their caring role. Therefore, healthcare providers should support them in learning to provide high-quality care. Evaluating caregivers’ ability will be the first step of this supportive programme. Aim: The aim of this study was to determine the caring ability of the caregivers of cancer patients and its related factors. Methods: This descriptive correlational study was performed with 271 caregivers of cancer patients who were selected through convenience sampling conducted from July to December 2021 in selected hospitals in Tehran, the capital city of Iran. The data were collected using the caring ability of family caregivers of patients with cancer scale (CAFCPCS), which was developed by Nemati et al (2020) . In addition, the stability reliability coefficient was calculated to be ICC=0.93. Data analysis was performed through Statistical Package for the Social Sciences (version 26), using descriptive and inferential statistics and correlation coefficient tests at a significance level of 0.05. Results: The mean score for the caring ability of the family caregivers of cancer patients in this study was 91.86±7.59. The mean total score of caring ability scale had a statistically significant correlation with the type of cancer and the duration of patient care (P-value=0.05). Conclusion: The results of the study demonstrated that the family caregivers of cancer patients do not have the necessary knowledge and awareness to perform their caring role effectively. Therefore, it is recommended to empower caregivers and use strategies to improve their trust, especially in caregivers who oversee patient care for a significant period of time.
Aprendizaje-servicio y comunicación en las ONG locales: una propuesta para la ONG Maset de Frater
Authors: Ibarra-Limiñana Rafael , Mallén-Broch Fermín , Tortosa-Edo Vicent 
Published: September 2023

INTRODUCCIÓN. El presente trabajo se enmarca en una experiencia de innovación docente, en la que se propone un proyecto de aprendizaje-servicio (ApS) centrado en la ONG local Maset de Frater. Esta organización está integrada por personas con discapacidad. El principal objetivo del artículo es mostrar cómo implementar una campaña de concienciación («ApS microhistorias de vida»), a realizar por alumnado del módulo formativo Marketing Digital y centrada en los integrantes de dicha ONG. Asimismo, se presenta la valoración que diferentes agentes implicados hacen de la propuesta.
MÉTODO. Se adopta una metodología cualitativa basada en la realización de entrevistas multifocales. En concreto, se entrevistó en profundidad a tres profesores del ciclo formativo Marketing y Publicidad en el IES La Mola (Novelda, Alicante) y al tutor del grupo de teatro que forma parte de la ONG Maset de Frater (Castelló).
RESULTADOS. Se evidencia que la propuesta de ApS puede ser de utilidad para el aprendizaje del alumnado y para ofrecer un servicio a la ONG Maset de Frater.
DISCUSIÓN. La investigación contribuye académicamente al mostrar las ventajas que, según los implicados, tiene esta propuesta de innovación docente. Finalmente, se recomienda realizar este proyecto de manera interdisciplinar entre diferentes módulos del ciclo formativo.
Photoelasticity of CNGS crystals
Authors: Mytsyk Bohdan , Erba Alessandro , Maul Jefferson , Demyanyshyn Nataliya , Shchepanskyi Pavlo , Syrotynsky Oleh 
Published: September 2023

All piezo-optic coefficients (POCs) and elasto-optic coefficients (ELOCs) of Ca3NbGa3Si2O14 (CNGS) and Ca3TaGa3Si2O14 (CTGS) trigonal crystals of the langasite group are determined from quantum mechanical calculations based on the hybrid density functional theory, as implemented in the CRYSTAL program. The calculation results for CTGS crystals are compared with experimental data. Indicative surfaces of piezo- and elasto-optic effects are constructed based on the POC and ELOC matrices of CNGS crystals and the largest values of these effects are determined. The maximum values of the coefficient of the acousto-optic figure of merit M2 of the CNGS crystal are determined for the geometries of elasto-optic interaction, which correspond to the maxima of the elasto-optic effect. These results are compared to the corresponding results for CTGS and langasite crystals. The spectral dependence of the POCs and ELOCs of CNGS and CTGS crystals on the light wavelength is investigated in the 600–1500 nm range.
Decision to delivery interval for emergency caesarean section in Eastern Uganda: A cross-sectional study
Authors: Apako Teddy , Wani Solomon , Oguttu Faith , Nambozo Brendah , Nahurira Doreck , Nantale Ritah , Kamwesigye Assen , Wandabwa Julius , Obbo Stephen , Mugabe Kenneth , Mukunya David , Musaba Milton W. 
Published: September 2023

Introduction
The decision to delivery interval is a key indicator of the quality of obstetric care. This study assessed the decision to delivery interval for emergency cesarean sections and factors associated with delay.

Methods
We conducted a cross-sectional study between October 2022 and December 2022 in the labor ward at Mbale regional referral hospital. Our primary outcome variable was the decision to delivery interval defined as the time interval in minutes from the decision to perform the emergency caesarean section to delivery of the baby. We used an observer checklist and interviewer administered questionnaire to collect data. Stata version 14.0 (StataCorp; College Station, TX, USA) was used to analyze the data.

Results
We enrolled 352 participants; the mean age was 25.9 years and standard deviation (SD) ±5.9 years. The median (interquartile range) decision to delivery interval was 110 minutes (80 to 145). Only 7/352 (2.0%) participants had a decision to delivery time interval of ≤30 minutes. More than three quarters 281 /352 (79.8%) had a decision to delivery interval of greater than 75 minutes. Emergency cesarean section done by intern doctors compared to specialists [Adjusted Prevalence Ratio (aPR): 1.26; 95% CI: (1.09–1.45)] was associated with a prolonged decision to delivery interval.

Conclusion
The average decision to delivery interval was almost 2 hours. Delays were mostly due to health system challenges. We recommend routine monitoring of decision to delivery interval as an indicator of the quality of obstetric care.
Influence of scar age, laser type and laser treatment intervals on adult burn scars: A systematic review and meta-analysis
Authors: Ma Yangmyung , Barnes Sabrina P. , Chen Yung-Yi , Moiemen Naiem S. , Lord Janet M. , Sardeli Amanda V. 
Published: September 2023

Aim
The study aims to identify whether factors such as time to initiation of laser therapy following scar formation, type of laser used, laser treatment interval and presence of complications influence burn scar outcomes in adults, by meta-analysis of previous studies.

Methods
A literature search was conducted in May 2022 in seven databases to select studies on the effects of laser therapy in adult hypertrophic burn scars. The study protocol was registered with PROSPERO (CRD42022347836).

Results
Eleven studies were included in the meta-analysis, with a total of 491 patients. Laser therapy significantly improved overall VSS/POSAS, vascularity, pliability, pigmentation and scar height of burn scars. Vascularity improvement was greater when laser therapy was performed >12 months (-1.50 [95%CI = -2.58;-0.42], p = 0.01) compared to <12 months after injury (-0.39 [95%CI = -0.68; -0.10], p = 0.01), the same was true for scar height ((-1.36 [95%CI = -2.07; -0.66], p<0.001) vs (-0.56 [95%CI = -0.70; -0.42], p<0.001)). Pulse dye laser (-4.35 [95%CI = -6.83; -1.86], p<0.001) gave a greater reduction in VSS/POSAS scores compared to non-ablative (-1.52 [95%CI = -2.24; -0.83], p<0.001) and ablative lasers (-0.95 [95%CI = -1.31; -0.59], p<0.001).

Conclusion
Efficacy of laser therapy is influenced by the time lapse after injury, the type of laser used and the interval between laser treatments. Significant heterogeneity was observed among studies, suggesting the need to explore other factors that may affect scar outcomes.