bluuebunny/crossref_metadata_2025_split huggingface dataset:
PROTAGONISMO DO ECOSSISTEMA CATARINENSE DE INOVAÇÃO
Authors: Felizola Matheus Pereira Mattos , De Aragão Iracema Machado de Aragão , Silva Amanda Luiza Soares 
Published: September 2023

A presente pesquisa teve como objetivo analisar o ecossistema de inovação do estado de Santa Catarina, a partir do confronto da literatura científica e dos resultados da pesquisa empírica. Na metodologia qualitativa, buscou-se um protocolo de estudo de caso, a partir de uma amostra não probabilística por cotas. Como fontes de evidências foram realizadas entrevistas semiestruturadas, observação não participante, análise de documentos, registro em arquivos e artefatos físicos. Para o embasamento teórico, foi realizada uma revisão sistemática do conceito, atores e casos de ecossistema de inovação a partir da análise de publicações na base de dados da Web of Science. Como técnica de pesquisa, utilizou-se a análise de conteúdo com o auxílio do software Nvivo 12 licenciado para analisar todo o conteúdo investigado. Observa-se que Santa Catarina tem um ecossistema de inovação maduro e pulverizado entre os seus 295 municípios. É um ambiente com intenso desenvolvimento de inovação e tecnologia, onde despontam atores, tais como, a Associação Catarinense de Tecnologia (ACATE), o Sistema S, a Universidade Federal de Santa Catarina (UFSC), o Parque Sapiens, o Governo de Santa Catarina e outros atores de inovação espalhados por vários municípios. A conexão do ecossistema de Santa Catarina, está muito atrelada aos seus 13 polos de inovação, que são responsáveis por interligar as diversas regiões geográficas.
Palavras-chave: Empreendedorismo. Habitats de Inovação. Conexão. Inovação. Santa Catarina.
RNA Interference and Neuromuscular Diseases: A Focus on Hereditary
Transthyretin Amyloidosis
Authors: Ceccanti Marco , Inghilleri Maurizio 
Published: September 2023

Abstract:
Neuromuscular diseases are severe disorders affecting the peripheral nervous system, usually
driving to death in a limited time. Many new drugs, through RNA-interference technology, are revolutionizing
the prognosis and quality of life for these patients. Nevertheless, given the increased life expectancy,
some new issues and phenotypes are expected to be revealed. In the transthyretin-mediated hereditary
amyloidosis (ATTR-v, "v" for "variant"), the RNA interference was demonstrated to effectively reduce
the hepatic synthesis of transthyretin, with a significant increase in disease progression in terms of
polyneuropathy and cardiomyopathy. The increased life expectancy could promote the involvement of
organs where the extra-hepatic transthyretin is deposited, such as the brain and eye, which are probably
not targeted by the available treatments. All these issues are discussed in this editorial.
Quality by Design (QbD): A Comprehensive Understanding and
Implementation in Pharmaceuticals Development
Authors: Pawar Sarita S. , Mahale Yash S. , Kalamkar Prachi A. , Satdive Rohini A. , Sonawane Sujata K. , Bhapkar Sneha P. 
Published: September 2023

Abstract:
Quality by Design (QbD) is a systematic approach for improvement that stresses product
and process and begins with a predetermined objective, as recommended by the USFDA and International
Council Harmonization (ICH). Regulatory bodies frequently highlight the use of ICH
quality criteria, which include Q8, Q9, Q10, and Q11. The differentiation between the traditional
and QbD helps to study the risk assessment and technique for developing new products. There are
a few steps involved in pharmaceutical and Analytical QbD. Various factors were used for the
study of QbD, such as Analytical Target Product Profile (ATPP), Risk Assessment Quality Design
Space, Control Strategy, etc. Critical Quality Attribute (CQA) may be understood and analyzed via
a way of means of understanding the goods and technique and risk evaluation is useful for effective
verbal exchange among FDA and industry, research/improvement and production, and amongst a
couple of production sites inside the company. Life-cycle management of analytical procedure begins
off evolving with the establishment of ATP and maintains until the approach is in use. The design
of the experiment (DoE) involves the Q8 guidelines. DoE has been used in the rational development
and optimization of analytical methods. Culture media composition, mobile phase composition,
flow rate, and time of incubation are input factors (independent variables) that may be
screened and optimized using DoE. Process analytical technology is implemented for the understanding
and identification of developing a product and techniques. There are various benefits and
applications of QbD in the pharmaceutical industry.
PLTS Terapung: Review Pembangunan dan Simulasi Numerik Untuk Rekomendasi Penempatan Panel Surya di Waduk Cirata
Authors: Marupa Ivan , Moe Idham Riyando , Mardjono Airlangga , Malindo Duki 
Published: September 2023

PLTS Terapung adalah salah satu proyek strategis nasional dari pemerintah Indonesia. Review teknis dan sosial adalah hal yang perlu dipertimbangkan.Â Dalam hal teknis, beberapa hal yang perlu dipertimbangkan dalam penempatan panel PLTS Terapung adalah inflow, velocity, tinggi gelombang, distribusi sediment melayang dan angin kencang. Selain itu, lokasi penempatan PLTS terapung tidak dekat dengan lokasi spillway pada Bendungan. Pada aspek sosial, keterlibatan dan pelaksanaan koordinasi yang baik antara stakeholder dan pihak terkait sangat perlu dalam tahap perencanaan, terutama meyakinkan masyarakat terhadap penerimaan PLTS Terapung. Sebagai evaluasi teknis, simulasi numeris dilakukan dalam memberikan rekomendasi area panel PLTS Terapung di area Waduk Cirata. Simulasi numerik dilakukan untuk memahami kondisi terberat yang akan dialami oleh PLTS Terapung khususnya pada kondisi ekstrim dan angin kencang. Hasil simulasi akan menunjukkan lokasi dengan kecepatan aliran dan konsentrasi sedimen paling kecil untuk penempatan PLTS Terapung. Sebagai hasil analisa didapatkan area seluas 242.93 Ha atau Â± 4.1% dari total luas genangan Waduk Cirata. Area ini adalah area genangan dengan kecepatan aliran air minimal, yakni < 5 cm/s, dan konsentrasi sedimen layang < 10 gr/m3. Nilai tersebut dapat dijadikan penilaian awal dalam melakukan rekomendasi penempatan panel PLTS Terapung di area Waduk Cirata.
Improvement, Implementation, and Evaluation of the CMyLife Digital Care Platform: Participatory Action Research Approach
Authors: Verweij Lynn , Metsemakers Sanne J J P M , Ector Geneviève I C G , Rademaker Peter , Bekker Charlotte L , van Vlijmen Bas , van der Reijden Bert A , Blijlevens Nicole M A , Hermens Rosella P M G 
Published: September 2023

BackgroundThe evaluation of a continuously evolving eHealth tool in terms of improvement and implementation in daily practice is unclear. The CMyLife digital care platform provides patient-centered care by empowering patients with chronic myeloid leukemia, with a focus on making medication compliance insightful, discussable, and optimal, and achieving optimal control of the biomarker BCR-ABL1.ObjectiveThe aim of this study was to investigate to what extent the participatory action research approach is suitable for the improvement and scientific evaluation of eHealth innovations in daily clinical practice (measured by user experiences) combined with the promotion of patient empowerment.MethodsThe study used iterative cycles of planning, action, and reflection, whereby participants’ experiences (patients, health care providers, the CMyLife team, and app suppliers) with the platform determined next actions. Co-design workshops were the foundation of this cyclic process. Moreover, patients filled in 2 sets of questionnaires for assessing experiences with CMyLife, the actual use of the platform, and the influence of the platform after 3 and at least 6 months. Data collected during the workshops were analyzed using content analysis, which is often used for making a practical guide to action. Descriptive statistics were used to characterize the study population in terms of information related to chronic myeloid leukemia and sociodemographics, and to describe experiences with the CMyLife digital care platform and the actual use of this platform.ResultsThe co-design workshops provided insights that contributed to the improvement, implementation, and evaluation of CMyLife and empowered patients with chronic myeloid leukemia (for example, simplification of language, and improvement of the user friendliness of functionalities). The results of the questionnaires indicated that (1) the platform improved information provision on chronic myeloid leukemia in 67% (33/49) of patients, (2) the use of the medication app improved medication compliance in 42% (16/38) of patients, (3) the use of the guideline app improved guideline adherence in 44% (11/25) of patients, and (4) the use of the platform caused patients to feel more empowered.ConclusionsA participatory action research approach is suited to scientifically evaluate digital care platforms in daily clinical practice in terms of improvement, implementation, and patient empowerment. Systematic iterative evaluation of users’ needs and wishes is needed to keep care centered on patients and keep the innovation up-to-date and valuable for users.
Development of an Information Guideline for Kidney Transplant Recipients in a Clinical Trial: Protocol for a Modified Delphi Method
Authors: Faraldo-Cabana Araceli , Sánchez-Fructuoso Ana , Pérez-Flores Isabel , Beneit-Montesinos Juan Vicente , Muñoz-Jiménez Daniel , Peix Jiménez Belén , Asensio Arredondo Sara , Nuño Santana Enriqueta Isabel , Santana Valeros María José , Hidalgo González Virginia , González García Fernando , Ortuño-Soriano Ismael 
Published: September 2023

Background
Renal transplantation is the treatment of choice for most cases of end-stage renal disease. Recipients need to lead a healthy lifestyle to minimize the potential side effects of immunosuppressive drugs and improve transplant outcomes. There is not much evidence about the best way to increase adherence to healthy lifestyles in kidney transplant recipients, so one of the objectives set by the nursing team is to train people to acquire the necessary skills and tools to be able to take care of themselves. In this sense, the consensual development of appropriate materials may be useful and of interest.

Objective
The aim of this study was to develop an information guide for adults with kidney transplants to be assessed in a subsequent clinical trial as an intervention to increase adherence to healthy habits.

Methods
We used a 3-step, methodological, sequential approach: (1) training from a group of experts and item consensus; (2) review of the medical literature available; and (3) use of the Delphi technique with on-site meetings. A total of 5 nurses from the Community of Madrid Kidney Transplantation Unit in Spain were asked to participate. The patients’ lifestyle factors that, according to the medical literature available and experts’ opinions, have the greatest impact on the survival of the transplanted organ and the recipients themselves were all described.

Results
After using the modified Delphi method to reach a consensus on the items to be included and the information needed in each, an information guide for adult kidney transplant patients was developed. This guide facilitates the structuring of health care, information, and recommendations necessary for effective self-care for each person. The result is considered to be an easy-to-understand tool, useful for transplant doctors and nurses, in simple language, with information based on the latest scientific-medical evidence published to date, aspects of which will be evaluated in a clinical trial designed for this purpose.

Conclusions
Currently, this guide is the main intervention variable of a clinical trial (registered on ClinicalTrials.gov; NCT05715580) aimed at improving compliance with healthy habits in kidney transplant recipients in the Community of Madrid, Spain. The method used in its development has been useful and agile, and the result is a guide that can be easily updated periodically following the same procedure.

International Registered Report Identifier (IRRID)
DERR1-10.2196/46961
The Potential of ChatGPT as a Self-Diagnostic Tool in Common Orthopedic Diseases: Exploratory Study
Authors: Kuroiwa Tomoyuki , Sarcon Aida , Ibara Takuya , Yamada Eriku , Yamamoto Akiko , Tsukamoto Kazuya , Fujita Koji 
Published: September 2023

Background
Artificial intelligence (AI) has gained tremendous popularity recently, especially the use of natural language processing (NLP). ChatGPT is a state-of-the-art chatbot capable of creating natural conversations using NLP. The use of AI in medicine can have a tremendous impact on health care delivery. Although some studies have evaluated ChatGPT’s accuracy in self-diagnosis, there is no research regarding its precision and the degree to which it recommends medical consultations.

Objective
The aim of this study was to evaluate ChatGPT’s ability to accurately and precisely self-diagnose common orthopedic diseases, as well as the degree of recommendation it provides for medical consultations.

Methods
Over a 5-day course, each of the study authors submitted the same questions to ChatGPT. The conditions evaluated were carpal tunnel syndrome (CTS), cervical myelopathy (CM), lumbar spinal stenosis (LSS), knee osteoarthritis (KOA), and hip osteoarthritis (HOA). Answers were categorized as either correct, partially correct, incorrect, or a differential diagnosis. The percentage of correct answers and reproducibility were calculated. The reproducibility between days and raters were calculated using the Fleiss κ coefficient. Answers that recommended that the patient seek medical attention were recategorized according to the strength of the recommendation as defined by the study.

Results
The ratios of correct answers were 25/25, 1/25, 24/25, 16/25, and 17/25 for CTS, CM, LSS, KOA, and HOA, respectively. The ratios of incorrect answers were 23/25 for CM and 0/25 for all other conditions. The reproducibility between days was 1.0, 0.15, 0.7, 0.6, and 0.6 for CTS, CM, LSS, KOA, and HOA, respectively. The reproducibility between raters was 1.0, 0.1, 0.64, –0.12, and 0.04 for CTS, CM, LSS, KOA, and HOA, respectively. Among the answers recommending medical attention, the phrases “essential,” “recommended,” “best,” and “important” were used. Specifically, “essential” occurred in 4 out of 125, “recommended” in 12 out of 125, “best” in 6 out of 125, and “important” in 94 out of 125 answers. Additionally, 7 out of the 125 answers did not include a recommendation to seek medical attention.

Conclusions
The accuracy and reproducibility of ChatGPT to self-diagnose five common orthopedic conditions were inconsistent. The accuracy could potentially be improved by adding symptoms that could easily identify a specific location. Only a few answers were accompanied by a strong recommendation to seek medical attention according to our study standards. Although ChatGPT could serve as a potential first step in accessing care, we found variability in accurate self-diagnosis. Given the risk of harm with self-diagnosis without medical follow-up, it would be prudent for an NLP to include clear language alerting patients to seek expert medical opinions. We hope to shed further light on the use of AI in a future clinical study.
Nutrient Evaluation for Sod Production within the Lake Okeechobee Watershed
Authors: McMillan Mica , Cisar John , McGroary Pauric , Snyder George , Fidanza Michael 
Published: September 2023

Abstract
Nutrient pollution from agricultural production is an environmental concern in the Everglades Agricultural Area. Sod farms within the Lake Okeechobee watershed in south Florida were surveyed to determine their production and fertilizer practices, and to determine the nitrogen (N) and phosphorous (P) impacts for the watershed. Ten of twenty sod farms participated in the in-person survey for a 50% response rate. Bahiagrass (Paspalum notatum) was grown on the greatest area at 5,463 ha (13,500 acres), followed-by St. Augustinegrass (Stenotaphrum secundatum) at 3,726 ha (9,208 acres), bermudagrass (Cynodon dactylon × C. transvaalensis. at 188 ha (465 acres), and zoysiagrass (Zoysia japonica) at 121 ha (299 acres). Growing and harvest cycle duration varied by turfgrass species. All farms follow guidelines for best management practices using fertilizer recommendations published by Florida’s Department of Agriculture and Consumer Services. The predominate nitrogen (N) source used was ammonium sulfate, and diammonium phosphate was the most commonly utilized phosphorous (P) source. Survey results indicated that 90% of sod farms had net exports of N and 100% of sod farms had net export of P. Thus, sod production provides a route for removing these two nutrients from this fragile hydrologically-linked ecosystem.
Species used in this study: bahiagrass (Paspalum notatum Flüggé), bermudagrass (Cynodon dactylon (L.) Pers. × C. transvaalensis Burtt-Davy, St. Augustinegrass (Stenotaphrum secundatum (Walt.) Kuntze), zoysiagrass (Zoysia japonica Steud.).
Natural Dyeing with Madder: Exploring Traditional Techniques and Color Characteristics
Authors: Tian Guangguo , Cui Rongrong , Liu Chuanlan , Hu Xiaorui 
Published: September 2023

Abstract
The color red has a significant presence in cultures around the world. The organic dye madder, derived from plants, has been used throughout human civilization and remains an important natural dye. The research reviews five traditional madder dyeing techniques from China, Europe, Turkey, and Japan. The techniques are applied to cotton, linen, silk, and wool fabrics, and their similarities and differences are compared and analyzed. Additionally, the environmental sustainability, resource conservation, and process efficiency of these dyeing techniques are also evaluated in this article. The chromatic value of dyed textile color was tested by means of an American Hunterlab spectrophotometer, the influence of different dyeing techniques on textile color characteristics was analyzed, and the artistic features of textile color were analyzed from the perspective of visual art.
BAC, U KRY! Space, Albanian Commemoration and the Gheg Variety as a Linguistic Symbol of State Independence in Postwar Kosovo
Authors: Demaj Uranela , Alla Aida 
Published: September 2023

Abstract
This paper investigates the reconstruction of Albanian identity in Kosovo after the region's transformation to state independence in 2008. The cultural environment emerged as a site of ethnic appropriation and contestation in the longstanding interethnic struggles between the Albanians and the Serbs. The study examines the socio-symbolic and linguistic manifestations of national identity in Pristina, the capital city of Kosovo, through the lens of Linguistic Landscape Studies. The first aspect of the study investigates M. Theresa Boulevard, the central promenade of the city and a site of memory and commemoration, to highlight how the period of South Slavic hegemony in Kosovo and the recent interethnic war resulted in a redefinition of Albanian identity. The second aspect of the study focuses on the written manifestation of the Gheg variety of Albanian as a symbol of Kosovo's independence. Through this dual focus on memory and language, the study aims to arrive at an understanding of how new national and political self-identifications are shaped in contexts that have undergone ethno-political conflicts and socio-political shifts. We argue that the symbolic configuration of Kosovo suggests a redefinition of Kosovo-based Albanian identity following the transformation to state independence. The study contributes to an understanding of the multi-layered redefinition of Albanian identity in Kosovo, calling attention to language and memory in the process of constructing national identities in postwar contexts.
Experimental Investigation on the Impact of Micro-Steel Fibers on the Flat Slabs' Punching Shear Resistance
Authors: Salman Ban A. , Hassan Rafea F. 
Published: September 2023

This research examined the effects of micro-straight steel fiber percentage and column form on the punching shear of SFRC slabs. Fibers made of micro steel with a diameter of 0.2 mm and a length of 13mm with an aspect ratio equal to 65 were used. The fiber content varied between 0.5%, 1%, and 1.5% by volume. Four different types of concrete mixes were adopted and tested. Experimental results showed that when the percentage of steel fibers in SFRC increased, its compressive strength, flexural strength, splitting tensile strength, and direct tensile strength improved. This investigation applied a monotonic load to eight cast slabs (two each of conventional concrete of square and circular column sections of the equivalent area while the other six slabs were made with steel fiber concrete. The dimensions of each slab were (920 x 920 x 80 ) mm. Each slab specimen had essential, edge-based support with square and round column sections. It has been demonstrated that slabs with square column sections endured a relatively higher ultimate load than slabs with circular column segments when the steel fiber dosage was 0.5% or 1.0%. Still, at a steel fiber dosage of 1.5%, circular column segment slabs approached the ultimate load of square column segment slabs. The heterogeneous behavior in concrete can be attributed to the random and unequal distribution of steel fibers throughout the material. There were only flexural fractures visible on the tensile face of the slab. New fractures emerged in the center of the slab as the load increased.
invidia e a ambitionis como motivação para os conflitos civis em Lucrécio
Authors: Freire Antonio Julio Garcia 
Published: September 2023

O poema filosófico De rerum natura (DRN) do epicurista Lucrécio (séc. I a.C.) foi escrito e publicado em um período de grande agitação social e política da República Romana. Ao longo do poema, Lucrécio indica a sua preocupação com os conflitos civis da sua época, fato que levou a algumas interpretações do DRN como um trabalho de natureza política (McCONNEL, 2012). Trata-se de uma tese estranha à tradição do Jardim, uma vez que o próprio Epicuro aconselhava o sábio a afastar-se de qualquer atividade política (DL, X, 2008). Tal interpretação pode ser baseada, principalmente, na apropriação do conceito de stásis, usado na antiguidade para denominar os conflitos e guerras civis entre as cidades-estado gregas. Em relação aos conflitos civis, Lucrécio trata de dois conceitos que estão relacionados à tais revoltas: o primeiro, é o da invidia. O segundo – o qual aparece de forma implícita no poema – é o da ambitionis. As duas noções estão ainda relacionadas a duas outras instâncias da argumentação de Lucrécio: a primeira diz respeito ao medo da morte como causa da invidia. A segunda, tem como foco, demonstrar como a ambitionis leva à queda de governantes e reis. O objetivo deste artigo é analisar passagens específicas do De rerum natura nos Livros III e V, verificando a maneira como Lucrécio relaciona os conflitos civis às noções de invidia e ambitionis.