bluuebunny/crossref_metadata_2025_split huggingface dataset:
Healing of a skin wound when using Trigonella foenum‑graecum against the background of experimental steroid hyperglycemia
Authors: Balykova L. A. , Inchina V. I. , Tarasova  T. V. , Myandina G. I. , Khaydar D. A. , Korovyakova E. A. , Mosina L. M. , Saushev I. V. , Tarasov R. S. , Bayburina G. A. , Bayburina D. E. , Trubitsyna I. E. 
Published: June 2023

Purpose. To evaluate the intensity of healing of an infected skin wound in rats using Trigonella foenum- graecum (Fenugreek) against the background of experimental steroid hyperglycemia.Materials and methods. The rats included in the study (n = 20) were divided into two equal groups. First, a model of steroid hyperglycemia was created for all animals. Then the same animals (n = 20) were used to create models of infected skin wound. The rats of the first group (the main one) were treated with wound surface ointment containing Trigonella foenum- graecum. Also, Trigonella foenum- graecum extract was constantly added to the water for the rats of the first group. Intact vaseline ointment was applied to the wound of the second group (control) rats. After 5 days, we evaluated the wound regeneration activity, blood glucose levels, and blood panel in all animals.Results. This study showed several positive aspects of the use of Trigonella foenum-g raecum in terms of treatment of infected skin wounds in animals with steroid hyperglycemia. The decrease in glucose levels almost to baseline values in the rats of the main group against the background of oral administration of Trigonella foenum-g raecum was recorded. By the end of the observation, the level of glycemia was almost two times less in animals of the first group compared to the second (p < 0.05). In animals of the first group, the number of leukocytes was higher compared to the second group, but this difference was not significant. However, we recorded a significant increase in the number of granulocytes by more than two times (p < 0.05), which indicates the immunomodulatory property of Trigonella foenum- graecum, which affected the regeneration activity of the infected wound in a positive way in rats of the first group.Conclusion. As a result of this study, promising prospects have been obtained for the use of the plant‑ derived drug Trigonella foenum- graecum in the correction of hyperglycemia and the treatment of infected wounds. Application of fenugreek topically in the form of an extract reduced inflammation and improved wound healing in rats suffering from steroid hyperglycemia.
Ciudadanías desbordadas: apuntes sobre agua y comunidad en tres prácticas artísticas
Authors: Ponce de León Alejandro 
Published: June 2023

El agua se presenta en las obras de las artistas Diana Marcela Buitrón, Dayana Camacho y Mariangela Aponte, y argumenta que los excesos de los cuerpos de agua en la práctica artística pueden ser considerados intervenciones éticas y políticas en la conversación sobre el cuidado y la reparación de las ecologías líquidas en el territorio. El ensayo tiene dos objetivos: abrir una reflexión sobre las múltiples crisis del agua y cómo estas demandan nuevas formas de habitar el presente en comunidad, y destacar la capacidad generativa de las prácticas artísticas para proponer formas más justas, inclusivas y sostenibles de relacionarse.
Urgent intraoperative cytological diagnosis of spherical mass lesions in the lungs
Authors: Kruglova I. A. , Paranina T. V. , Zinoviev S. V. , Utkin O. V. , Denisenko A. N. 
Published: June 2023

Differential diagnosis of pulmonary mass lesions is one of the most difficult tasks not only in pulmonology but also in phthisiology, because clinical manifestations, data from visual and laboratory examinations are undifferentiated in the early stages. In the case of an unclear diagnosis, morphological verification of the process played a crucial role. Urgent intraoperative examination is the most difficult option for morphologic verification of lung lesions, which requires a quick, detailed, and accurate answer.The aim of this study was to evaluate the clinical significance and efficacy of urgent intraoperative cytologic examination in the differential diagnosis between granulomatous (tuberculosis, sarcoidosis), tumor and tumor-like lesions of the lung.Methods. The results of urgent intraoperative cytologic examination of 173 tissue specimens from lung masses were retrospectively analyzed. Cytologic specimens were stained by the May – Grunwald – Giemse and Ziehl – Neelsen methods and then visualized on a Zeiss Lab A1 microscope (Carl Zeiss, Germany). The obtained data are compared with the results of histological examination. To evaluate the effectiveness of intraoperative cytologic examination, the accuracy, sensitivity, and specificity were calculated.Results. Analysis of the results of urgent cytological examinations (n = 173) shows that granulomatosis (tuberculosis/sarcoidosis) was established in 64.7% of cases, malignancy – in 31 cases (cancer – 9.2%, carcinoid tumor – 2.9%, malignant neoplasm of unclear etiology – 4%, suspected malignant lesion – 1.7%); benign process – in 9.2% of cases (hamartoma + chondroma – 5.2%, chronic inflammation – 4%). 1.2% of the cases had no diagnostic material. When comparing the obtained results, there was a discrepancy between the histological picture (2.9% of cases) and the primary clinical diagnosis (5.7% of cases). Sensitivity, specificity, and accuracy of cytologic examination of intraoperative material amounted to 95.9, 71, and 98%, respectively.Conclusion. The high sensitivity and accuracy (> 90%) of urgent cytologic diagnosis of pathologic processes in the lung under intraoperative conditions were demonstrated by the correct assessment of morphologic signs of a given lesion and by their comparison with the clinical picture and the results of additional examinations. Analysis of cytological specimens showed that urgent cytological examination significantly complements the morphological picture of lung lesions and can be considered as the first stage of phenotypic diagnosis.
Psychosomatic functional disorders in pulmonary practice
Authors: Ovcharenko S. I. , Troshina D. V. , Sokolova P. S. , Volel B. A. 
Published: June 2023

The relevance of studying psychosomatic disorders in somatic clinical practice (including pulmonary practice) stems from the significant prevalence of these disorders, as well as the difficulties in making a differential diagnosis and choosing the most effective tactics for patient management.The aim of this review was to analyze the available publications on the problem of psychosomatic functional disorders in pulmonary practice, such as hyperventilation syndrome (HVS), including HVS associated with Severe Acute Respiratory Syndrome-related CoronaVirus 2 (SARS-CoV-2) infection, vocal cord dysfunction, and psychogenic cough. The article discusses clinical features of different variants of functional disorders and accompanying psychopathological symptoms (panic attacks, generalized anxiety, etc.), as well as psychogenic factors of their manifestation and changes in the clinical features over time. The corresponding section briefly summarizes current ideas about approaches to effective treatment of this group of disorders and prevention of their chronification.Conclusion. The clinical heterogeneity of psychosomatic functional disorders in pulmonological practice has been demonstrated, as have important aspects of the diagnosis and treatment of these disorders.
Pulmonary contusion: clinical reasoning
Authors: Chuchalin A. G. , Zaitsev A. A. , Kulikova N. A. , Likhodiy V. I. , Davydov D. V. 
Published: June 2023

According to statistics, chest injuries rank third in prevalence and are characterized by high mortality, which is 35 – 45%. This article presents a patient diagnosed and treated for bilateral pulmonary contusion with post-traumatic pneumonitis after a combined mine-explosive injury.Purpose. Of particular interest to the clinician is the understanding of lung injury from the standpoint of interpretation of diagnosis, methods of diagnosis, and differential diagnosis with pneumonia, prevention of complications, and rational treatment tactics. The terms “pneumonitis” and “pneumonia” are not synonymous. In modern terminology, it is customary to use the term pneumonitis for a pathologic process in the alveoli without an infectious process in the vast majority of cases, and infectious forms of pulmonary inflammation are referred to as pneumonia. In this clinical case (and in similar situations), it is advisable to take into account the pathogenesis of changes in lung tissue after pulmonary contusion, leading to post-traumatic pneumonitis, which often requires additional specific therapy and rehabilitation for rapid recovery of lung function. Proper tactics in prescribing anti-inflammatory and antibacterial drugs are critical, as is treatment aimed at preventing complications, including prevention of fibrous changes in the lung.Conclusion. Given the relevance of this topic, it is currently advisable to introduce monitoring of CRP and procalcitonin levels, coagulogram, and gas composition of arterial blood, if necessary, in the patient management. It is advisable to use computed tomography to clarify the nature of the changes. The problem of follow-up and rehabilitation of patients with chest injuries and pulmonary contusion is relevant.
Obstructive sleep apnea syndrome: nocturnal intermittent hypoxia and telomerase complex activity
Authors: Madaeva I. M. , Kurashova N. A. , Berdina O. N. , Titova E. V. , Semenova N. V. , Kolesnikov S. I. , Kolesnikova L. I. 
Published: June 2023

Obstructive sleep apnea syndrome (OSAS) is a common pathology of the respiratory system characterized by upper airway blockage during sleep. The blockage is caused by intermittent throat collapse and thereby no lung ventilation with preserved respiratory efforts. Earlier we demonstrated that telomeres at the end of chromosomes shorten during intermittent nocturnal hypoxia and sleep fragmentation in OSA patients; the elimination of OSA triggers contributed to an increase in relative telomere length (RTL). The search for the relationship between telomeres and the telomerase complex activity with the sleep stages, as well as indicators of blood oxygen saturation in OSA, seems relevant.Aim. To evaluate the activity of the telomerase complex main components and to determine its relationship with the sleep phases and the level of desaturation in patients with OSA.Methods. The main group included 32 men (age 51.2 ± 3.1 years) with complaints of snoring, respiratory arrest during sleep, and increased daytime sleep. The control group consisted of 26 matched volunteers without clinical manifestations of OSA. Patients of both groups did not have any exacerbations of their chronic conditions at baseline. The study included questionnaires, polysomnography monitoring, analysis of the RLT by PCR, ELISA to determine activity of the telomerase complex components, and statistical analysis.Results. Differences were revealed in the functioning of telomeres and the TERT, TEP1. A positive relationship between the oxygen blood saturation, telomere length and TER1 activity was found in OSA patients.Conclusion. We have identified the decrease in RTL and the telomerase complex activity and proved their positive relationship with the oxygen saturation during intermittent nocturnal hypoxia in OSA patients.
ДІАГНОСТИКА ЛОЯЛЬНОСТІ ПЕРСОНАЛУ ПІДПРИЄМСТВ ЗАЛІЗНИЧНОГО ТРАНСПОРТУ
Authors: Панченко Н. Г. 
Published: June 2023

Статтю присвячено вивченню лояльності працівників підприємств залізничного транспорту з метою забезпечення конкурентоспроможності і сталого розвитку залізничної галузі в довгостроковій перспективі. Розкрито підходи до визначеннясутності поняття «лояльність персоналу» і з’ясовано його характерні риси.Встановлено напрямки і інструменти проведення діагностики лояльності персоналу.На основі проведеного анкетування і кластерного аналізу ідентифіковано стан лояльності персоналу підприємств залізничної галузі.
Acciones de educación en emergencia para el conflicto armado y la pandemia, caso: San José del Guaviare 2002 – 2021
Authors: Zuluaga Trujillo Gustavo Antonio 
Published: June 2023

Objetivo: Analizar prácticas de Educación en Emergencia realizadas por organismos nacionales como el Ministerio de Educación Nacional e internacionales como la UNESCO, Save the Children, la Red Interagencial para la Educación en Situaciones de Emergencia y docentes durante el periodo 2002-2018 del conflicto armado colombiano.

Originalidad/aporte: Está dada por el tratamiento de la Educación en Emergencia en el tiempo de conflicto y posacuerdo (2016-2018) y el abordaje del impacto de la pandemia para contextualizar el tiempo presente que, aunque no esté en la estimación temporal, se hace como aporte a otras formas de Educación en Emergencia diferentes a las ocasionadas por el conflicto armado que resultan útiles para el desarrollo de programas educativos para el posacuerdo.

Método: la investigación se organiza desde el paradigma cualitativo, fundamentado epistemológicamente desde el modelo histórico hermenéutico gadameriano, documental, y fenomenológico.

Estrategias/recolección de información: para la interpretación hermenéutica se utilizan las historias de vida de maestros de San José del Guaviare, recogidas y analizadas mediante entrevistas, estudio de archivos y anecdotarios publicados por docentes de la comunidad educativa guaviarense desde los inicios del Siglo XXI.

Conclusiones: de acuerdo con el análisis de las respuestas obtenidas en las entrevistas y tendiendo en cuenta la perspectiva gadameriana, se comprende que la experiencia de Educación en Emergencia, realizada en el Guaviare, impactó favorablemente y sirvió de apoyo a las poblaciones resilientes de la región.
La red académica pedagogías, paz y poblaciones resilientes: su productividad y pertinencia social
Authors: Mora García José Pascual , Mansilla Sepulveda Juan Guillermo , Correa Alfonso José Del Carmen , Fregoso Bailón Raul Olmo 
Published: June 2023

Objetivo: mostrar la producción intelectual de la red académica Pedagogías, Paz y Poblaciones Resilientes (PPPR) y su pertinencia social con los documentos emanados del Estado Educador.
Originalidad/aporte: Se realizaron trabajos conjuntos (grupos e instituciones) para el análisis de las pedagogías emergentes, la paz decolonial y las poblaciones resilientes/vulnerables, para mejorar la calidad de vida del sector de la población que ha sido víctima de los conflictos político-sociales. Pero también para sensibilizar a la población sobre un tema especialmente neurálgico que atañe a la nación colombiana y marco supranacional.[1]
Método: etnográfica y pluriversa, para esto se reflexiona sobre las experiencias concretas, vividas en el trabajo; para lo cual se presenta el impacto social en el contexto Cundiboyacense, así como los actores y las maneras de interactuar con la comunidad y proyección a futuro.
Estrategias/recolección de información: Los datos se decantan del estudio de los siguientes apartados: 1. Categorías maceradas y presentadas a la Comunidad Científica, entre ellas: Paz Transmoderna, Pedagogías Alternativas; Pedagogía de la Resiliencia; e Historia de la Educación Transmoderna; 2. Eventos; 3. Productividad de la Línea de Investigación; 4. La creación de programas de formación, como es el caso del Doctorado en Ciencias de la Educación de la Universidad de Cundinamarca (UdeC); y 5. Proyectos de Investigación finalizados y en proceso. Epistemológicamente se orienta en el giro decolonial y transmoderno.
Conclusiones: Se concluye que la red PPPR le apuesta a la formación, socialización e internacionalización con tasa de retorno social en el que se interioriza los alcances del Acuerdo Final de Paz. Hoy con los resultados del Informe Final de la Verdad se perfila con una visión prospectiva que reivindica los entornos locales, translocales y el localismo globalizado.
[1] Antecedentes en esta investigación pueden ser: José Pascual Mora García et Arnaldo D' Yongh Sosa (2014) “Educación en Emergencias (EeE): Una realidad que promete desarrollo. Experiencias en Haití; México, caso Ayotzinapa.” Heurística, No. 017. http://www.saber.ula.ve/handle/123456789/40105
Redes académicas y grupos de investigación en Iberoamérica
Authors: Mora García José Pascual , Gómez Velasco Nubia Yaneth 
Published: June 2023

El volumen 24, número 39 de la Revista de Historia de la Educación Latinoamericana -RHELA, recupera la memoria de la maestra argentina Olga Cossettini (1898-1987), pionera de la Escuela Nueva en Santa Fe- Argentina, y está dedicada a las “Redes académicas y de investigación.” La Rhela es por antonomasia la expresión de la publicación periódica de la Sociedad de Historia de la Educación Latinoamericana (SHELA), por lo que resulta un compromiso el presentar los avances de las redes que se han generado a partir de ésta y redes alternativas. En ese sentido es una experiencia que conjuga el trabajo de los grupos de investigación y en red, para presentar los resultados y la tasa de retorno social de las mismas. En el marco de los 30 años del Grupo Hisula -UPTC (1992-2022), es un compromiso el presentar la productividad sobre el tema objeto de estudio, pues ha sido gestor del conocimiento en red. Es un estudio necesario y urgente, en momentos en la inteligencia artificial reta a la producción de conocimientos resultados de proyectos de investigación y con fundamentos en contextos vulnerables y resilientes.
El monográfico se inicia con el estudio monográfico de la maestra Olga Cossettini (1898-1987), a cargo de la investigadora de la Universidad Nacional de Córdoba, María Cristina Vera de Flachs. Es un estudio que decanta la historia de vida de la maestra Olga Cossettini, con una larga trayectoria en la provincia de Santa Fe, a partir del Archivo Pedagógico Cossettini. La contribución se traduce en redimensiona la metodología de la Escuela Activa en una modalidad que definió como la Escuela Serena
Studying Anti-virulence Activity of Meta-Bromo-Thiolactone against <em>Staphylococcus aureus</em> and MRSA Phenotypes
Authors: Alfaraj Rihaf , Eltayb Esra K , AlFayez Bashayer M , Abohamad Amjad S , Eltaher Eram , Alenazi Naifa A , Hababah Sandra , Alkahtani Hamad M , Almangour Thamer A. , Alqahtani Fulwah Y , Aleanizy Fadilah Sfouq 
Published: June 2023

Of late, the focus has been shifted towards quorum sensing inhibitors which reduce bacterial virulence and lower the probability of resistance and refining infections. In this work, meta-bromo-thiolactone (mBTL), a potent quorum and virulence inhibitor against Staphylococcus aureus and MRSA phenotypes, was formulated in chitosan nanoparticles (ChNPs) using ionic gelation method. mBTL-loaded-ChNPs were characterized for particle size, polydispersity index, zeta potential. Morphology was visualized by Transmission Electron Microscopy (TEM), drug release profile and antibiofilm analysis using Confocal Laser Scanning Microscope (CLSM) and Scanning Electron Microscopy (SEM) were performed. Synthesized mBTL-loaded-CNPs showed homogenized nano-size particles ranging from 158+1.3 to 284+5.6 nm with spherical particles that exhibited sustainable release profile over 48 hr at 37 °C. These findings revealed successful preparation of mBTL-loaded-ChNPs, that further showed effective antibiofilm activity at MIC50 (0.5 mg/mL) where all strains displayed reduced biofilm formation compared to untreated strains. CLSM results showed a significant reduction in the number of viable cells, indicating the effectiveness of m-BTL as an antibacterial agent. SEM analysis permitted visualization of biofilm structure in relation to the spatial localization of important biofilm matrix components, the formed biofilms were clearly distinguished in the SEM images. Bacterial cells in the control group were enclosed in thick biofilms. In contrast, there was a considerable reduction in biofilm production when mBTL was present, where bacterial cells seemed less ordered and more scattered with no detectable biofilms. In conclusion, mBTL-loaded-ChNPs is a potential alternative treatment to overcome antimicrobial resistance and condensed MRSA infections.
Burying Hatchets into Endemic Diagnoses: Disseminated Blastomycosis in a Novel Occupational Exposure
Authors: Davar Kusha , Jeng Arthur , Donovan Suzanne 
Published: June 2023

Blastomycosis is an endemic fungal disease seen prominently in the northern regions of North America, manifested as pulmonary disease, however also with dissemination to the skin, bones, and genitourinary tract. We describe a case of a patient in Southern California diagnosed with disseminated blastomycosis due to a novel occupational exposure of axe throwing.
INTEGRATED CALCULATION AND EXPERIMENTAL TECHNOLOGY FOR ANALYSIS OF CONTACT INTERACTION WITH ACCOUNT OF ELASTIC INTERMEDIATE LAYER
Authors: Tkachuk Mykola M. , Hrechka Iryna , Tkachuk Mykola А. , Sierykov Volodymyr , Grabovskiy Andrey , Pinchuk Natalia , Tkachuk Нanna , Klochkov Illia , Tsendra Heorgii , Shevchenko Andriy , Kyrychuk Vladyslav , Friziuk Dmytro 
Published: June 2023

The work delivers solution to a relevant scientific problem of solid mechanics. It consists in developing theoretical basis for computational and experimental research of contact interaction of complex-shaped bodies with account for micromechanical models of roughness and other intermediate or surface layers. New methods and models have been developed for the analysis of contact interaction of complex-shaped bodies with account for the micromechanical properties of surface and intermediate layers characterized by nonlinear local contact stiffness. The developed methods and models as well as the numerical analysis tools have been applied to a series of model and applied problems. The deformation behaviour of novel materials with network microstructures of one-dimensional elements has been determined. Macroscopical properties of these materials have been evaluated based on the special microscopic models and the homogenization methods. Regularities in contact distribution and its dependence on geometrical and physical factors have been determined for various complexshaped bodies. New design solutions for machine elements that improve their strength and durability have been justified. The developed methods and analysis tools have been introduced into the design of new engineering products. Their implementation resulted in improved technical characteristics of protection, structural and functional elements of transport vehicles of special purpose, gear transmissions, technical equipment, hydrovolumetric drives and so on. The conducted computational and experimental studies showed good agreement with the real response of network materials and the observed behavior of interacting elastic bodies with intermediate contact layer.
Keywords: solid mechanics, complex-shaped body, contact interaction, contact pressure, intermediate layer
Manajemen Risiko Sistem Informasi Ujian Secara Daring Di Sekolah Tinggi Manajemen Asuransi Trisakti
Authors: Syahrial Sidik Syahrial Sidik , Wahyuari Wahyuari 
Published: June 2023

Penelitian ini bertujuan untuk menegtahui manajemen risiko Sistem Informasi Ujian secara Daring di Sekolah Tinggi Manajemen Asuransi Trisakti (STMA Trisakti). Penelitian ini menggunakan data yang bersifat primer yang didapat dari sumber datanya yakni wakil ketua I, kepala bidang Kompti, dosen dan mahasiswa, dianalisa sesi proses manajemen risiko yakni Komunikasi dan Konsultasi, Penentuan Konteks, Penilaian Risiko, Perlakuan Risiko, monitoring dan review. Teknik sampling yang digunakan adalah non-probability sampling (purposive sampling) dan resiko akan dianalisa menggunakan probability impact matrix. Berdasarkan hasil analisis risiko Sistem Informasi Ujian secara Daring terdapat 3 risiko dengan kategori medium yaitu : Sistem informasi ujian online sesuai prosedur ujian online, Pengelolan risiko ujian online terkendali (manageable) oleh KOMPTI, Pemeliharaan sistem tinggi.