bluuebunny/crossref_metadata_2025_split huggingface dataset:
Titin fragment is a sensitive biomarker in Duchenne muscular dystrophy model mice carrying full-length human dystrophin gene on human artificial chromosome
Authors: Hiramuki Yosuke , Hosokawa Miwa , Osawa Kayo , Shirakawa Taku , Watanabe Yasuhiro , Hanajima Ritsuko , Kugoh Hiroyuki , Awano Hiroyuki , Matsuo Masafumi , Kazuki Yasuhiro 
Published: January 2025

Abstract
Duchenne muscular dystrophy (DMD) is an X-linked recessive disorder caused by mutations of the dystrophin gene, which spans 2.4 Mb on the X chromosome. Creatine kinase (CK) activity in blood and titin fragment levels in urine have been identified as biomarkers in DMD to monitor disease progression and evaluate therapeutic intervention. However, the difference in the sensitivity of these biomarkers in DMD remains unclear. Previously, we generated transchromosomic mice carrying the full-length human dystrophin gene on a human artificial chromosome (DYS-HAC1) vector. The human dystrophin derived from DYS-HAC1 improved pathological phenotypes observed in DMD-null mice, which lack the entire 2.4 Mb of the dystrophin gene. In this study, we compared the values of plasma CK activity and urine/plasma titin fragment levels in wild-type (WT), DYS-HAC1, DMD-null, and DYS-HAC1; DMD-null mice. Plasma CK activity and urine/plasma titin fragment levels in DMD-null mice were significantly higher than those in WT mice. Although plasma CK activity showed no significant difference between WT and DYS-HAC1; DMD-null mice, urine/plasma titin fragment levels in DYS-HAC1; DMD-null mice were higher than those in WT mice. Human dystrophin in DYS-HAC1; DMD-null mice drastically improved muscular dystrophy phenotypes seen in DMD-null mice; however, the proportion of myofibers with central nuclei in DYS-HAC1; DMD-null mice had a tendency to be slightly higher than that in WT mice. These results suggest that urine/plasma titin fragment levels could be a more sensitive biomarker than plasma CK activity.
Comparative effective dose of ciprofol and propofol in suppressing cardiovascular responses to tracheal intubation
Authors: Liao Min , Wu Xiao-Ru , Hu Jia-Ning , Lin Xing-Zhou , Zhao Tang‑yuan‑meng , Sun Hu 
Published: January 2025

Abstract
Ciprofol, a novel γ-aminobutyric acid receptor agonist, outperforms propofol with minimal cardiovascular effects, higher potency, reduced injection pain, and a broader safety margin. Despite these advantages, ciprofol’s clinical research is still emerging. This study compares the median effective dose (ED50) and adverse reactions of ciprofol and propofol, in conjunction with sufentanil, for suppressing cardiovascular responses during tracheal intubation. Fifty-three adult patients scheduled for tracheal intubation under general anesthesia were enrolled and randomly assigned to receive either ciprofol (Group C) or propofol (Group P), according to a random number table. Tracheal intubation was performed using a standardized laryngoscope and endotracheal tube. The Dixon’s up-and-down method was employed to determine the ED50 and 95% effective dose (ED95) of ciprofol and propofol in inhibiting cardiovascular responses during tracheal intubation. Based on the pilot study, the initial dose for ciprofol was set at 0.35 mg/kg (with a 0.01 mg/kg increment) and for propofol at 2.0 mg/kg (with a 0.1 mg/kg increment). Probit analysis was applied to derive dose-response curves, while adverse reactions were continuously monitored. A total of 54 participants were included, with 24 in group C (1 excluded) and 30 in group P. Probit analysis revealed that the ED50 of ciprofol for inhibiting cardiovascular responses to tracheal intubation were 0.326 mg/kg (95% CI 0.304–0.337 mg/kg), and for propofol, 1.541 mg/kg (95% CI 1.481–1.599 mg/kg). The heart rate in group P was significantly higher than the group C at 1 minute (p = 0.026) and 3 minutes (p = 0.016) post-intubation. Systolic and diastolic blood pressures (SBP and DBP) decreased significantly before and after intubation compared to baseline values in both groups (p< 0.05). Group C experienced significantly less injection pain (p = 0.001), although the incidence of other adverse effects was not statistically different between groups (p > 0.05).

Clinical Trial Registration: hppts://ClinicalTrials.gov; Identifier: NCT06095570(18/10/2023).
Future large-scale atmospheric circulation changes and Greenland precipitation
Authors: Huai Baojuan , Ding Minghu , van den Broeke Michiel R. , Reijmer Carleen H. , Noël Brice , Sun Weijun , Wang Yetang 
Published: January 2025

AbstractIn this work, we examine connections between patterns of future Greenland precipitation and large-scale atmospheric circulation changes over the Northern Hemisphere. In the last three decades of the 21st century, CMIP5 and CMIP6 ensemble mean precipitation significantly decreases over the northern part of the North Atlantic Ocean with respect to 1951–1980. This drying signal extends from the ocean to the southeastern margin of Greenland. The 500 hPa geopotential height change shows a clear pattern including a widespread increase across the Arctic with a negative anomaly centered over Iceland and surrounding regions. To identify the mechanisms linking atmospheric circulation variability with Greenland precipitation, we perform a singular value decomposition (SVD) and center of action (COA) analysis. We find that a northeastward shift of the Icelandic Low (IL) under the SSP5‐8.5 warming scenario leads to the drying signal found in southeast Greenland. This implies that the IL location will have a strong influence on precipitation changes over southeast Greenland in the future, impacting projections of Greenland ice sheet surface mass balance.
From video to vital signs: a new method for contactless multichannel seismocardiography
Authors: Rahman Mohammad Muntasir , Kakavand Bahram , Van Wurm William , Holman William L. , Movahed Mohammad Reza , Taebi Amirtahà 
Published: January 2025

AbstractSeismocardiography (SCG) is a technique that non-invasively measures the chest wall’s local vibrations caused by the heart’s mechanical activity. Traditionally, SCG signals have been recorded using accelerometers placed at a single location on the chest wall. This study presents an innovative, cost-effective SCG method that utilizes standard smartphone videos to capture data from multiple chest locations. The analysis of vibrations from multiple points can offer a more thorough understanding of the heart’s mechanical activity compared to signals obtained solely from a single chest location. Our approach employs computer vision and deep learning techniques to extract and improve the resolution of multichannel SCG maps obtained by video capture of chest movement. We attached a grid of patterned stickers to the chest surface and recorded videos of chest movements during different respiratory phases. Using a deep learning-based object detector and a template tracking method, we tracked the stickers across video frames and extracted the corresponding SCG signals from sticker displacements. We also developed a robust algorithm to estimate heart rate (HR) from these chest videos and identify the optimal chest location for HR estimation. The method was tested on 28 chest videos captured from 14 healthy participants. The results demonstrated that our method effectively extracted multichannel SCG maps and enhanced their resolution with a mean squared error of 0.1078 and 0.0418 for right-to-left and head-to-foot SCG signals, respectively. We observed intersubject chest vibration patterns corresponding to cardiac events including opening and closure of the heart valves. Moreover, our algorithm accurately estimated HR from 1968 SCG signals extracted from the videos compared to the gold-standard HR measured from each subject’s electrocardiogram (bias ± 1.96 SD = 0.04 ± 2.14 bpm; r = 0.99, p < 0.001). The findings from this study underscore the potential of our approach in developing a cardiac monitoring tool using a smartphone that would be widely accessible to the general public and might provide more timely detection of diseases.
Photocatalyst-free formate-mediated C–O cleavage by the EDA complex and SCS strategy for the synthesis of diaryl 1,4-diketone in air
Authors: Zhao Molai , Liu Yutong , Chen Xueqin , Peng Min , Wang Yawen , Liu Xiangwei , Jiang Hezhong , Tan Rui , Li Jiahong 
Published: January 2025

Under visible light, formates enable C–O cleavage via the EDA complex and SCS strategy, generating α-carbonyl alkyl radicals that react with olefins to form diaryl 1,4-dicarbonyl compounds. α-Formyloxy ketone is formed in situ from α-brominated acetophenone and formates.
Innovative distribution network design using GAN‐based distributionally robust optimization for DG planning
Authors: Li Peijin , Shen Yichen , Shang Yitong , Alhazmi Mohannad 
Published: January 2025

AbstractThe integration of renewable energy sources and the increasing demand for reliable power have posed significant challenges in the design and operation of distribution networks under uncertain conditions. The inherent variability in renewable energy generation and fluctuating consumer load demand requires advanced strategies for Distributed Energy Resources (DERs) allocation and sizing to enhance grid resilience and operational efficiency. This article introduces an innovative framework for optimizing distribution network design under these uncertainties. The approach integrates deep learning‐assisted Distributionally Robust Optimization (DRO) with Generative Adversarial Networks (GANs) to dynamically model and manage the inherent variability in renewable sources and demand fluctuations. Employing a combination of nonlinear optimization techniques and advanced statistical methods, the framework robustly optimizes network configurations to minimize losses and improve voltage stability. The model's efficacy is rigorously tested on the IEEE 33‐bus system, achieving a 15% reduction in power distribution losses and a 20% improvement in voltage stability compared to traditional models. Utilizing open‐source computational tools, the method not only boosts operational reliability and efficiency but also adapts effectively to the increasing integration of volatile renewable energy sources. These results underscore the framework's potential as a scalable and robust solution for modern power network design challenges.
Seamless augmented reality integration in arthroscopy: a pipeline for articular reconstruction and guidance
Authors: Shu Hongchao , Liu Mingxu , Seenivasan Lalithkumar , Gu Suxi , Ku Ping‐Cheng , Knopf Jonathan , Taylor Russell , Unberath Mathias 
Published: January 2025

AbstractArthroscopy is a minimally invasive surgical procedure used to diagnose and treat joint problems. The clinical workflow of arthroscopy typically involves inserting an arthroscope into the joint through a small incision, during which surgeons navigate and operate largely by relying on their visual assessment through the arthroscope. However, the arthroscope's restricted field of view and lack of depth perception pose challenges in navigating complex articular structures and achieving surgical precision during procedures. Aiming at enhancing intraoperative awareness, a robust pipeline that incorporates simultaneous localization and mapping, depth estimation, and 3D Gaussian splatting (3D GS) is presented to realistically reconstruct intra‐articular structures solely based on monocular arthroscope video. Extending 3D reconstruction to augmented reality (AR) applications, the solution offers AR assistance for articular notch measurement and annotation anchoring in a human‐in‐the‐loop manner. Compared to traditional structure‐from‐motion and neural radiance field‐based methods, the pipeline achieves dense 3D reconstruction and competitive rendering fidelity with explicit 3D representation in 7 min on average. When evaluated on four phantom datasets, our method achieves root‐mean‐square‐error reconstruction error, peak signal‐to‐noise ratio and structure similarity index measure on average. Because the pipeline enables AR reconstruction and guidance directly from monocular arthroscopy without any additional data and/or hardware, the solution may hold the potential for enhancing intraoperative awareness and facilitating surgical precision in arthroscopy. The AR measurement tool achieves accuracy within and the AR annotation tool achieves a mIoU of 0.721.
Angiotensin-converting gene and hypoxic exercise tolerance: a
randomized crossover trial
Authors: Muramoto Yuki , Momoi Mizuki , Nakashima Daisuke , Omae Kakeru , Sugai Kazuhisa , Daigo Kyohei , Iwasawa Yuji , Ichihara Genki , Okawara Hiroki , Sawada Tomonori , Kinoda Akira , Yamada Yuichi , Kimura Takeshi , Sato Kazuki , Katsumata Yoshinori 
Published: January 2025

AbstractHypoxic training enhances endurance sports tolerance. However, individual responses vary
due to physiological differences. This study investigated the relationship between
genetic factors and exercise tolerance in hypoxic conditions. This randomized crossover
study included 22 male university students (age 20.8±1.3 years, peak oxygen uptake
54.5±6.5 mL/min/kg). Incremental load tests were conducted to assess the symptomatic
limit on separate days under normoxic and hypoxic conditions (oxygen concentration
15.4±0.8%) using an ergometer. The initial test environment was randomized. The peak
oxygen uptake and blood lactate were monitored every minute, and Δ peak oxygen uptake
(peak oxygen uptake under hypoxia – peak oxygen uptake under normoxia) was calculated.
Sixteen genotypes linked to exercise tolerance (such as angiotensin-converting enzyme
[ACE]) were examined. Peak oxygen uptake significantly decreased under hypoxia
(p<0.01). Δ peak oxygen uptake varied among individuals (minimum: 0.7 and maximum:
− 18.9). Among analyzed genetic polymorphisms, ACE-II genotypes showed significantly
greater Δ peak oxygen uptake than ACE-ID/ACE-DD genotypes (p=0.02). ACE-II genotypes
exhibited lower blood lactate elevation at peak exercise in normoxic (p=0.01) and
hypoxic (p=0.03) conditions. Participants with the ACE-II genotype had lower lactate
concentrations and greater reductions in peak oxygen uptake under hypoxic conditions.
Optimizing hypoxic training requires individualized programs incorporating genetic
analysis.
Description of the Uncinate Process: A Computed Tomography Cross-Sectional Study
Authors: El-Anwar Mohammad Waheed , Alawady Mohamed Kamel , El-Hussiny Ashraf , Albasiouny Mohamed Talaat , Alloush Hany , Abdelhamid Hoda Ismail 
Published: January 2025

Abstract
Introduction The uncinate process (UP) is the most important and constant landmark in the ostiomeatal complex and the middle meatus.
Objective To identify the UP variations that have not been published before and establish a categorization using computed tomography (CT).
Methods The current study was carried out on 110 paranasal CT scans (220 sides). Axial images were acquired with multiplanar reformats to capture delicate details in other planes.
Results Out of 120 CT scans (220 sides), the UP was found to be of type 1 in 84.5%, type 2 in 12.3%, and type 3 in 3.2%, without significant diferences between genders, and it was found to be medialized in 81.9%, vertical in 16.3%, lateralized in 0.9%, and absent in 0.9%, without significant differences between genders. A total of 8.63% of the UPs were pneumatized.
Conclusion The present study improves surgeons' and radiologists' knowledge of the UP, while creating a standard classification and description to be used as a common language between otorhinolaryngologists and radiologists, which could also be used for training.
Moringa oleifera L. Nanosuspension Extract Administration Affects Heat Shock Protein-10 and -70 under Orthodontics Mechanical Force In Vivo
Authors: Triwardhani Ari , Alida Alida , Winoto Ervina Restiwulan , Pramusita Adya , Putranti Nurul Aisyah Rizki , Ariadi Kristian Satrio , Pribadi Okso Brillian , Anwar Amelia Aisyiah , Purnamasari Alqomariyah Eka , Mappananrang Rifqah Ananda , Situmorang Putri Cahaya , Riawan Wibi , Noor Tengku Natasha Eleena binti Tengku Ahmad , Nugraha Albertus Putera , Nugraha Alexander Patera 
Published: January 2025

Abstract
Objective The mechanical stimulation known as orthodontic mechanical force (OMF) causes biological reactions in orthodontic tooth movement (OTM). Heat shock protein-70 (HSP-70) needs pro-inflammatory cytokines to trigger bone resorption in OTM; nevertheless, heat shock protein-10 (HSP-10), a “Alarmin” cytokine, should control these pro-inflammatory cytokines to get the best alveolar bone remodeling (ABR). Moringa oleifera L. nanosuspension extract (MONE) has anti-inflammatory, antioxidant, and ABR-stimulating properties. The aim of the study was to examine in vivo HSP-10 and HSP-70 expressions under OMF following MONE application in Wistar rats (Rattus norvegicus).
Material and Methods A total of 36 Wistar rats (R. norvegicus) were split up into eight groups: one for treatment (OMF + MONE) and one for control (OMF + MONE administration for days 1, 7, 14, and 21). By employing nickel–titanium coil springs and using 10 g of light force per millimeter to implant the orthodontic device, the OMF was completed. According to the day of observation, all of the samples were sacrificed. To perform an immunohistochemistry investigation, the premaxilla of the sample was isolated. Tukey's Honest Significant Different (HSD) test (p < 0.05) was performed after an Analysis of Variance (ANOVA) analysis of the data.
Results In both the OMF and MONE groups, HSP-70 peaked on day 14 and began to fall on day 21. HSP-10 peaked on day 21, but along with MONE, it also began to progressively decline on days 14 and 21, with significant differences (p < 0.05).
Conclusion According to immunohistochemistry evidence, postadministration of MONE markedly elevated HSP-10 but lowered HSP-70 expression in the alveolar bone of Wistar rats under OMF.
Cerebellar Mutism/Posterior Fossa Syndrome Following Resection of Posterior Fossa Tumor in Pediatric Patients: Assessing Pathophysiology, Risk Factors, and Neuroradiographic Features
Authors: Setia Vikrant , Zeya Monirah , Srivastava Arvind Kumar , Jagetia Anita 
Published: January 2025

Background Cerebellar mutism syndrome (CMS) is a postoperative syndrome of decreased speech seen in children associated with neurobehavioral abnormalities, the incidence of which is up to 40%.
Objective To evaluate pediatric patients with posterior fossa tumors for incidence, clinical characteristics, pathophysiology, risk factors, and neuroradiographic features of this syndrome.
Materials and Methods The study included 60 pediatric patients with a posterior fossa tumor who underwent surgery by a telovelar approach. Detailed pre- and postoperative clinical and radiological evaluations were done. Patients with CMS were analyzed and compared with those without mutism to find risk factors for CMS. The presentation and characteristics of cerebellar mutism were studied along with the following risk factors:The preoperative, immediate postoperative, and 1-year postoperative imaging results were reviewed to assess the neuroradiographic features in the two groups.
Results The incidence of this syndrome was 20%. The mutism was accompanied by some neurobehavioral abnormalities (p-value = 0.05). The most significant finding was the presence of a period of cerebellar dysarthria after the resolution of the muteness (p-value < 0.001) in all cases. Brainstem and related structures' involvement was the most significant risk factor (p-value = 0.03). The presence of brainstem and peduncular edema in the immediate postoperative period (p-value = 0.04) and gross atrophy of posterior fossa structures at 1 year (p-value = 0.01) showed significance toward the development of CMS. There was delayed neurological recovery in patients with CMS with a poor Glasgow Outcome Score at 1 year of follow-up.
Conclusion The clinical presentation of this syndrome in context with neuroradiographic features suggests that it results from transient impairment of the afferent and/or efferent pathways of dentate nuclei that are involved in initiating complex volitional movements and are associated with brainstem involvement of tumor and poor functional outcome.
Postoperative Musculoskeletal Imaging and Interventions Following Hip Preservation Surgery, Deformity Correction, and Hip Arthroplasty
Authors: Samim Mohammad , Khodarahmi Iman , Burke Christopher , Fritz Jan 
Published: January 2025

AbstractTotal hip arthroplasty and hip preservation surgeries have substantially increased over the past few decades. Musculoskeletal imaging and interventions are cornerstones of comprehensive postoperative care and surveillance in patients undergoing established and more recently introduced hip surgeries. Hence the radiologist's role continues to evolve and expand. A strong understanding of hip joint anatomy and biomechanics, surgical procedures, expected normal postoperative imaging appearances, and postoperative complications ensures accurate imaging interpretation, intervention, and optimal patient care. This article presents surgical principles and procedural details pertinent to postoperative imaging evaluation strategies after common hip surgeries, such as radiography, ultrasonography, computed tomography, and magnetic resonance imaging. We review and illustrate the expected postoperative imaging appearances and complications following chondrolabral repair, acetabuloplasty, osteochondroplasty, periacetabular osteotomy, realigning and derotational femoral osteotomies, and hip arthroplasty.
An electro-optically tunable arrayed waveguide grating fabricated on thin film lithium niobate
Authors: Wang Zhe , Fang Zhiwei , Zhu Yiran , Liu Jian , Gao Lang , Yu Jianping , Zhang Haisu , Wang Min , Cheng Ya 
Published: January 2025

We design and fabricate an eight-channel thin-film lithium niobate (TFLN) arrayed-waveguide grating (AWG) and demonstrate the electro-optical tunability of the device. The monolithically integrated microelectrodes are designed for waveguide phase modulation and wavelength tuning. Experiments show that the fabricated electro-optically controlled TFLN AWG has a channel spacing of 200 GHz and a wavelength tuning efficiency of 10 pm/V.
When excuse me means excuse you!
Authors: Küttner Uwe-A. 
Published: January 2025

Abstract
This article examines the use of excuse me as a practice for invoking the complainability of
another person’s conduct in the service of sanctioning it as misconduct. It explores how a form that semantically
expresses its speaker’s desire to be excused (excuse me
) can be used to
flag another person’s doings as transgressive or untoward. It is proposed that, to elucidate this puzzle, it is
necessary to adopt a more holistic perspective and to incorporate other uses of the format (e.g., in other-initiated repair, as an
attention-drawing device), as well as possible relationships between them, into the analysis. The paper offers a sketch of such a
more holistic, integrative account. This account revolves around the idea that practices of speaking that mobilize similar or even
the same linguistic resources implicate partially overlapping sets of affordances for action which link different usages together
in a larger pragmatic landscape. As such, form-based practices of speaking and the various actions they can implement exhibit
demonstrable relationships across different domains of use which may need to be taken into account when thinking about a
practice’s fit to the action it implements. One of the key benefits of such an approach is that it allows for mapping out larger
pragmatic landscapes and to move beyond the isolated description of individual practices of speaking.