bluuebunny/crossref_metadata_2025_split huggingface dataset:
Treatment Engagement as a Predictor of Therapy Outcome Following Cognitive Behaviour Therapy for Autistic Children
Authors: Albaum Carly S. , Sellitto Teresa , Vashi Nisha , Bohr Yvonne , Weiss Jonathan A. 
Published: August 2023

Abstract
Purpose
Active engagement in one’s therapy is a key contributor to successful outcomes. Research on child engagement in cognitive behaviour therapy (CBT) has largely focused on youth without autism. This longitudinal study examined multiple indicators of child engagement in relation to outcomes for autistic children who took part in CBT for emotion regulation. Method: Data were collected from 60 autistic children who were between 8 and 13 years of age (86.7% male; Mage = 9.58 years, SD = 1.44 years; 75% White). Indicators of child engagement included independent observer ratings of in-session involvement, as measured by the Child Involvement Rating Scale, and therapist ratings of the therapeutic relationship and homework completion using single-item measures. Indicators of engagement were measured at early (i.e., first third), middle (i.e., mid third), and late (i.e., final third) stages of treatment. Parent-reported emotion regulation was the primary treatment outcome, as measured by the Emotion Regulation Checklist. Results: After controlling for pre-treatment scores, in-session involvement significantly predicted some aspects of post-treatment emotion regulation, whereas therapeutic relationship and homework completion did not. Conclusions: Child in-session involvement throughout therapy may be particularly relevant for treatment change. Addressing issues related to in-session involvement early in treatment may help to promote therapeutic success for autistic children.
Entering the grey zone of aging between health and disease: a critical phenomenological account
Authors: Zeiler K. , Segernäs A. , Gunnarson M. 
Published: August 2023

AbstractPhenomenological analyses of ageing and old age have examined themes such as alterity, finitude, and time, not seldom from the perspective of “healthy” aging. Phenomenologists have also offered detailed analyses of lived experiences of illness including lived experiences of dementia. This article offers a phenomenological account of what we label as entering the grey zone of aging between “healthy” aging and aging with a disease. This account is developed through a qualitative phenomenological philosophy analysis of elderly persons’ lived experiences of being tested for dementia through primary care in Sweden, i.e., within a cultural context where dementia commonly is understood as a frightening a loss of self even though this understanding also is questioned. To enter this grey zone of aging, we argue, does not dissolve dynamic self-becoming but can involve an experience of oneself as being old. Further, in the grey zone, the self experiences itself as neither fully healthy nor as having a disease, and as needing to negotiate and live this ambiguity. To enter this grey zone is to enter an affectively charged, sociocultural and medicalized zone, and while the self can still act in different ways within it, staying in the grey zone can result in a re-orientation in the self’s mode of being, in ways that are thoroughly beyond its control. To stay in the grey zone can have detrimental effects on the self, even though the self does not have a disease: the self can become “stuck” in a reflective mode of attending to embodiment, aging, health, and disease.
Oil radish, winter rye and crimson clover: root and shoot performance in cover crop mixtures
Authors: Kemper Roman , Döring Thomas F. , Legner Nicole , Meinen Catharina , Athmann Miriam 
Published: August 2023

Abstract

Purpose
The current knowledge of belowground interactions in intercropping systems is limited due to methodological constraints. The current study aimed to investigate cereal-brassica and cereal-legume-brassica cover crop mixtures regarding mixture effects on root and shoot biomass as well as root traits, vertical root niche differentiation, and complementarity.

Methods
Sole crops and two- and three-species-mixtures of winter rye (Secale cereale L.), crimson clover (Trifolium incarnatum L.), and oil radish (Raphanus sativus L. var. oleiformis Pers.) were grown in Germany in a two-year organic field experiment. Root traits were analysed using the monolith method. For discrimination of species root mass Fourier transform infrared (FTIR) spectroscopy was used.

Results
Oil radish dominated mixtures above- and belowground. Oil radish and its mixtures had highest root length density (RLD) and root mass density (RMD) in subsoil. Rye had highest root biomass and RLD in topsoil. Clover was uncompetitive and had low RLD and RMD. Large but non-significant mixture effects occurred in the shoot, especially for shoot nutrient uptake. Mixture effects were positive for RLD and RMD in subsoil and positive for specific root length (SRL) throughout the whole profile. There was no clear evidence for vertical root niche differentiation and root mass complementarity.

Conclusion
Oil radish as a mixing partner increased rooting in subsoil. When comparing mixtures and sole crops, morphological changes, i.e. higher SRL in mixtures, were found. Contrary to expectations, changes in root allocation patterns, such as vertical niche differentiation or complementarity of root mass, were not observed.
Split Cycle: a new Condorcet-consistent voting method independent of clones and immune to spoilers
Authors: Holliday Wesley H. , Pacuit Eric 
Published: August 2023

AbstractWe propose a Condorcet-consistent voting method that we call Split Cycle. Split Cycle belongs to the small family of known voting methods satisfying the anti-vote-splitting criterion of independence of clones. In this family, only Split Cycle satisfies a new criterion we call immunity to spoilers, which concerns adding candidates to elections, as well as the known criteria of positive involvement and negative involvement, which concern adding voters to elections. Thus, in contrast to other clone-independent methods, Split Cycle mitigates both “spoiler effects” and “strong no show paradoxes.”
Corporate Leniency Programs for Antitrust: Past, Present, and Future
Authors: Hinloopen Jeroen , Onderstal Sander , Soetevent Adriaan 
Published: August 2023

AbstractThis special issue marks the 25th anniversary of the introduction of a leniency program for antitrust in the EU and contains five original papers: Each paper examines the effects of design parameters of leniency programs on their performance. Before introducing each contribution separately, we put them in perspective by introducing readers to the existing theoretical, empirical, and experimental literature on corporate leniency programs for antitrust.
Realism and the point at infinity: The end of the line?
Authors: Parkinson-Coombs Oisín , Núñez Rafael 
Published: August 2023

AbstractPhilosophers of mathematics often rely on the historical progress of mathematics in support of mathematical realism. These histories typically build on formal semantic tools to evaluate the changes in mathematics, and on these bases present later mathematical concepts as refined versions of earlier concepts which are taken to be vague. Claiming that this view does not apply to mathematical concepts in general, we present a case-study concerning projective geometry, for which we apply the tools of cognitive linguistics to analyse the developmental trajectory of the domain. On the basis of this analysis, we argue for the existence of two conceptually incompatible inferential structures, occurring at distinct moments in history, both of which yield the same projective geometric theorems; the first invoked by the French mathematicians Girard Desargues (1591–1661) and Jean-Victor Poncelet (1788–1867), and the second characterising a specific modern mode. We demonstrate that neither of these inferential structures can be considered as a refinement of the other. This case of conceptual development presents an issue to the standard account of progress and its bearing on mathematical realism. Our analysis suggests that the features that distinguish the underlying conceptually incompatible inferential structures are invisible to the standard application of the tools of formal semantics. Thus this case-study stands as an example of the manner and necessity of linguistics—specifically cognitive linguistics—to inform the philosophy of mathematics.
Quantification in the interpretational theory of validity
Authors: Grossi Marco 
Published: August 2023

AbstractAccording to the interpretational theory of logical validity (IR), logical validity is preservation of truth in all interpretations compatible with the intended meaning of logical expressions. IR suffers from a seemingly defeating objection, the so-called cardinality problem: any instance of the statement ‘There arenthings’ is true under all interpretations, since it can be written down using only logical expressions that are not to be reinterpreted; yet ‘There arenthings’ is not logically true. I argue that the cardinality problem is indeed a serious problem for IR, when understood in terms of ‘asymmetry of information’. I then argue that IR can be rehabilitated by making quantifiers context-sensitive: what we do not reinterpret is the Kaplanian character of a quantifier, rather than its content. ‘There arenthings’ is false in a context where fewer thannthings are relevant, so it is not logically true in IR. I finally discuss some objections and ramifications of my account: I discuss how to make space for the possibility of an explicitly absolutely general quantifier in my framework, how terms can be logical even though context-sensitive, and how to recapture classical logic within my framework.
Targeting MerTK decreases efferocytosis and increases anti-tumor immune infiltrate in prostate cancer
Authors: Myers Chen Kayla V. , de Groot Amber E. , Mendez Sabrina A. , Mallin Mikaela M. , Amend Sarah R. , Pienta Kenneth J. 
Published: August 2023

AbstractThe prostate cancer tumor microenvironment (TME) is comprised of many cell types that can contribute to and influence tumor progression. Some of the most abundant prostate cancer TME cells are macrophages, which can be modeled on a continuous spectrum of M1-like (anti-tumor macrophages) to M2-like (pro-tumor macrophages). A function of M2-like macrophages is efferocytosis, the phagocytosis of apoptotic cells. Based on literature from other models and contexts, efferocytosis further supports the M2-like macrophage phenotype. MerTK is a receptor tyrosine kinase that mediates efferocytosis by binding phosphatidylserine on apoptotic cells. We hypothesize efferocytosis in the prostate cancer TME is a tumor-promoting function of macrophages and that targeting MerTK-mediated efferocytosis will slow prostate cancer growth and promote an anti-tumor immune infiltrate. The aims of this study are to measure efferocytosis of prostate cancer cells by in vitro human M1/M2 macrophage models and assess changes in the M2-like, pro-tumor macrophage phenotype following prostate cancer efferocytosis. Additionally, this study aims to demonstrate that targeting MerTK decreases prostate cancer efferocytosis and promotes an anti-tumor immune infiltrate. We have developed methodology using flow cytometry to quantify efferocytosis of human prostate cancer cells using the LNCaP cell line. We observed that M2 macrophages efferocytose the LNCaP cell line more than M1 macrophages. Following efferocytosis of LNCaP cells by M2 human monocyte-derived macrophages (HMDMs), we observed an increase in the M2-like, pro-tumor phenotype by flow cytometry cell surface marker analysis. By qRT-PCR, flow cytometry, and Western blot, we detected greater MerTK expression in M2 than M1 macrophages. Targeting MerTK with antibody Mer590 decreased LNCaP efferocytosis by M2 HMDMs, establishing the role of MerTK in prostate cancer efferocytosis. In the prostate cancer mouse model hi-myc, Mertk KO increased anti-tumor immune infiltrate including CD8 T cells. These findings support targeting MerTK-mediated efferocytosis as a novel therapy for prostate cancer.
Are agricultural extension systems ready to scale up ecological intensification in East Africa? A literature review with particular attention to the Push-Pull Technology (PPT)
Authors: Isgren Ellinor , Clough Yann , Murage Alice , Andersson Elina 
Published: August 2023

AbstractAgricultural extension, or advisory services, have a key role to play in supporting farmers’ learning and adoption of new practices and technologies. This paper analyses gaps and needs which require addressing in order for extension systems to more effectively contribute to the upscaling of ecological intensification approaches in East African smallholder agriculture. Our starting point is the push-pull technology (PPT), a promising approach. PPT originated in East Africa and is being continuously improved through cycles of interdisciplinary and participatory experimentation. Despite well-documented benefits to farmers and the environment, more institutional support from agricultural extension systems (AES) is needed for PPT to realise significant impact on poverty reduction, food security, and sustainability. Departing from this assessment, we review literature on AES in five East African countries. After clarifying the AES characteristics that ecological intensification requires, emphasising the capacity to embrace complexity, we identify four thematic areas that are in urgent need of attention: first, widely recognised problems with access and inclusiveness have seen welcome innovation but remain substantial. Second, information and communication technologies provide many benefits and new possibilities, but expectations must be tempered. Third, pluralistic AES present coordination challenges that risk undermining and misdirecting extension. Finally, the political-economic underpinnings of extension require critical scrutiny and strategic interventions. While many challenges threaten extension effectiveness broadly, we highlight implications for ecological intensification approaches like PPT. Our insights thus speak to the broader question of how to design and implement extension for sustainable agricultural development in East Africa.
Application of item response theory modelling to measure an aggregate food security access score
Authors: Charamba Vonai , Kazembe Lawrence N. , Nickanor Ndeyapo 
Published: August 2023

AbstractFood security measurement is of paramount importance as it guides governance, policy formulation and intervention projects targeting and monitoring and evaluation. The measurement of food insecurity has proven to be a difficult task owing to the multi-dimensionality of the construct and different measurements have been developed to measure different dimensions of food insecurity. However, it is difficult to apply the different measurements to a holistic food security measurement as their classification might not agree. The current study proposes a composite food insecurity indicator by aggregating items from Household Dietary Diversity Score (HDDS), Household Food Insecurity Access Scale (HFIAS) and Months of Inadequate Household Food Provision (MIHFP) for Windhoek households’ data into a single measure using the Rasch Testlet Response Model. The composite measure was internally validated against the HDDS, HFIAS and MIHFP and externally validated against household income and the Lived Poverty Index (LPI) using Spearman's Rank Correlation and Cohen's Kappa. The validation results suggest that the metric could be a promising measure of aggregate food insecurity worth further investigation and discussion. However, more research is needed in coming up with cut-points for categorizing households into food insecurity statuses. In addition, the metric has only been computed and tested on a single urban sample in the Global South and hence it is not generalizable to different setups. Other researchers who might want to use the index can try to estimate and validate the index in different scenarios and suggest ways the index can be improved.
Chemotherapy following immune checkpoint inhibitors in recurrent or metastatic head and neck squamous cell carcinoma: clinical effectiveness and influence of inflammatory and nutritional factors
Authors: Sakai Akihiro , Ebisumoto Koji , Iijima Hiroaki , Yamauchi Mayu , Teramura Takanobu , Yamazaki Aritomo , Watanabe Takane , Inagi Toshihide , Maki Daisuke , Okami Kenji 
Published: August 2023

Abstract
Objective
This study aimed to evaluate the clinical effectiveness of chemotherapy following immune checkpoint inhibitors (ICI). The association between inflammatory and nutritional factors and prognosis has also been investigated.

Methods
We retrospectively reviewed the medical records of recurrent or metastatic head and neck squamous cell carcinoma (RMHNSCC) patients who received chemotherapy following ICI therapy. The response rate and survival after chemotherapy, and nutritional and inflammatory factors, were examined.

Results
The ICI before chemotherapy was nivolumab in 36 patients (70.6%) and pembrolizumab in 15 patients (29.4%). The chemotherapy regimens consisted of PTX in 32 patients (62.7%), PTX + Cmab in 9 (17.6%), and S1 in 10 (19.6%). The median overall survival (OS) was 20 months (95% CI 12–25), the estimated 12-month OS rate was 63.3%, the median progression-free survival (PFS) was 5 months (CI 4–6), and the 12-month PFS estimate was 8.9%. Univariate analysis significantly correlated Neutrophil-to-Lymphocyte Ratio (NLR), platelet-to-lymphocyte ratio (PLR), controlling nutritional status score (CONUT), and prognostic nutrition index (PNI) with OS and PFS. Additionally, these factors were significantly correlated with OS and PFS in the log-rank tests.

Conclusions
Chemotherapy following ICI is highly effective. There were no significant differences in the chemotherapy regimens. Inflammatory and nutritional factors may associate with patient prognosis after chemotherapy.
OSR1 downregulation indicates an unfavorable prognosis and activates the NF-κB pathway in ovarian cancer
Authors: Yu Zhong , Ouyang Ling 
Published: August 2023

Abstract
Background
Odd-skipped related 1 (OSR1) has been reported as a tumor suppressor gene in various malignant tumors. The mechanism through which OSR1 regulates ovarian cancer (OC) progression remains unclear.

Materials and methods
Immunohistochemistry was utilized to evaluate OSR1 expression in patients with ovarian cancer. We investigated the association between clinicopathological parameters and OSR1 expression in OC patients and the influence of OSR1 expression on patient survival and prognosis. OC cells with OSR1 overexpression or knockdown were established and validated using Western blot and Quantitative reverse-transcription polymerase chain reaction (qRT-PCR). The influence of OSR1 on the NF-κB pathway was examined by analyzing the p-IκBα, IκBα, p65, and p-p65 protein expression. In vitro assays, such as cell cycle assay, Cell Counting Kit-8 (CCK-8), transwell invasion assay, wound healing migration assay, enzyme-linked immunoassay (ELISA), and Annexin V/PI flow cytometry apoptosis assay, were conducted to explore the effect of OSR1 knockdown or dual inhibition of OSR1 and the NF-κB pathway on OC malignant biological behavior.

Results
OSR1 expression was downregulated in OC tissues, with significant associations observed between its expression and The International Federation of Gynecology and Obstetrics (FIGO) stage and tissue differentiation. Low OSR1 expression in OC patients correlated with reduced overall survival (OS) rates and poor prognosis. In vitro, experiments confirmed a negative correlation between OSR1 expression and NF-κB pathway activity. OSR1 knockdown facilitated OC cell malignant biological behavior, while the NF-κB pathway inhibitor (Bay 11-0782) reversed the impacts of OSR1 knockdown on cell proliferation, migration, invasion, and apoptosis.

Conclusion
Our findings indicate that OSR1 is downregulated and associated with OC prognosis. OSR1 suppresses NF-κB pathway activity and inhibits OC progression by targeting the NF-κB pathway.
Effect of geometry and hydraulic parameters on the bed morphology in a confluence using numerical approach
Authors: Pourvahedi Milad , Hosseini Khosrow , Mousavi Sayed-Farhad , Geranmayeh Kiarash 
Published: August 2023

AbstractThe confluence of rivers is an important phenomenon that is really vital for irrigation and water transmission networks. Investigation on bed morphology at the junction of two streams is of great importance. Flow complexity at confluences, as well as being at risks of rising water levels and flooding, interfering with the use of bridges, filling the inlets of the ponds and reducing the efficiency of water transport are resulted by this phenomenon. The purpose of this research is to investigate the effect of geometric and hydraulic parameters, such as junction angle, width ratio of two intersected canals, and Froude number on the bed morphology at intersection, using SSIIM2. Validation of the results of numerical model in terms of hydraulic and morphology parameters indicated good correlations coefficients of 0.9 and 0.68, respectively. In the next step, the effect of intersection angle (45, 60, 75, 90 and 105 degrees) on the scour depth was investigated. By decreasing the junction angle from 105° to 45°, the maximum scour depth reduced to about 96% and the scour hole dimensions were smaller and moved toward the confluence shore. Furthermore, the results showed that by increasing the width ratio from 0.5 to 1, and also, decreasing the Froude number ratio of tributary to main channel from 3 to 0.68, maximum scour depth decreased by 25% and 30%, respectively.
Benefitting Nonhuman Animals with AI: Why Going Beyond “Do No Harm” Is Important
Authors: Bossert Leonie N. 
Published: August 2023

AbstractAI technologies affect not only humans in many ways but also sentient animals. When investigating the impact of AI on other animals, it is important to consider how these technologies can harm them. However, it is equally important to explore how they can be used to enable animals to live good lives and improve their wellbeing. In this article, I present the rationale for this claim (Section 1), highlight applications through which AI systems are or can be used to benefit nonhuman animals, and show how these benefits can be classified in terms of the harm framework proposed by Coghlan and Parker (Philosophy & Technology 36:25, 2023; Section 2). Finally, I identify open research questions that need to be addressed next (Section 3).
Public Biological Databases and the Sui Generis Database Right
Authors: Bernier Alexander , Busse Christian , Bubela Tania 
Published: August 2023

AbstractThe sui generis database right is an intellectual property right created in the European Union to stimulate investment in the curation of databases. Since its inception, communities engaged in research and development efforts have questioned its potential to incentivise database production, and posit that it stifles productive downstream uses of existing datasets. European courts have restricted the right’s ambit through a restrictive interpretation of the circumstances in which it applies, which we argue, enables downstream use of biological databases. Nonetheless, residual ambiguities about potential infringement of the right exist. The prospect of unintentional infringement can frustrate downstream innovation. These ambiguities are compounded because the criteria that determine whether or not the right applies are reliant on information that is not available to the prospective downstream users of public datasets. Repealing the sui generis database right is recommended. Legislatures are advised to refrain from the implementation of broad novel intellectual property rights in the future, without first adopting safeguards that mitigate the potential for such rights to frustrate the reuse of available intangibles to the detriment of pro-social innovation.