bluuebunny/crossref_metadata_2025_split huggingface dataset:
Observational Evidence for Cosmological Coupling of Black Holes and its Implications for an Astrophysical Source of Dark Energy
Authors: Farrah Duncan , Croker Kevin S. , Zevin Michael , Tarlé Gregory , Faraoni Valerio , Petty Sara , Afonso Jose , Fernandez Nicolas , Nishimura Kurtis A. , Pearson Chris , Wang Lingyu , Clements David L , Efstathiou Andreas , Hatziminaoglou Evanthia , Lacy Mark , McPartland Conor , Pitchford Lura K , Sakai Nobuyuki , Weiner Joel 
Published: February 2023

Abstract
Observations have found black holes spanning 10 orders of magnitude in mass across most of cosmic history. The Kerr black hole solution is, however, provisional as its behavior at infinity is incompatible with an expanding universe. Black hole models with realistic behavior at infinity predict that the gravitating mass of a black hole can increase with the expansion of the universe independently of accretion or mergers, in a manner that depends on the black hole’s interior solution. We test this prediction by considering the growth of supermassive black holes in elliptical galaxies over 0 < z ≲ 2.5. We find evidence for cosmologically coupled mass growth among these black holes, with zero cosmological coupling excluded at 99.98% confidence. The redshift dependence of the mass growth implies that, at z ≲ 7, black holes contribute an effectively constant cosmological energy density to Friedmann’s equations. The continuity equation then requires that black holes contribute cosmologically as vacuum energy. We further show that black hole production from the cosmic star formation history gives the value of ΩΛ measured by Planck while being consistent with constraints from massive compact halo objects. We thus propose that stellar remnant black holes are the astrophysical origin of dark energy, explaining the onset of accelerating expansion at z ∼ 0.7.
Discovery of Dust Emission Activity Emanating from Main-belt Asteroid 2015 FW412
Authors: Chandler Colin Orion , Trujillo Chadwick A. , Oldroyd William J. , Kueny Jay K. , Burris William A. , Hsieh Henry H. , Mazzucato Michele T. , Bosch Milton K. D. , Shaw-Diaz Tiffany 
Published: February 2023

Abstract
We present the discovery of activity emanating from main-belt asteroid 2015 FW412, a finding stemming from the Citizen Science project Active Asteroids, a NASA Partner program. We identified a pronounced tail originating from 2015 FW412 and oriented in the anti-motion direction in archival Blanco 4 m (Cerro Tololo Inter-American Observatory, Chile) Dark Energy Camera images from UT 2015 April 13, 18, 19, 21 and 22. Activity occurred near perihelion, consistent with the main-belt comets (MBCs), an active asteroid subset known for sublimation-driven activity in the main asteroid belt; thus 2015 FW412 is a candidate MBC. We did not detect activity on UT 2021 December 12 using the Inamori-Magellan Areal Camera and Spectrograph on the 6.5 m Baade telescope, when 2015 FW412 was near aphelion.
The JWST Resolved Stellar Populations Early Release Science Program. III. Photometric Star–Galaxy Separations for NIRCam
Authors: Warfield Jack T. , Richstein Hannah , Kallivayalil Nitya , Cohen Roger E. , Savino Alessandro , Boyer Martha L. , Garling Christopher T. , Gennaro Mario , McQuinn Kristen B. W. , Newman Max J. B. , Anderson Jay , Cole Andrew A. , Correnti Matteo , Dolphin Andrew E. , Geha Marla C. , Sandstrom Karin M. , Weisz Daniel R. , Williams Benjamin F. 
Published: February 2023

Abstract
We present criteria for separately classifying stars and unresolved background galaxies in photometric catalogs generated with the point-spread function fitting photometry software DOLPHOT from images taken of Draco II, WLM, and M92 with the Near Infrared Camera (NIRCam) on JWST. Photometric quality metrics from DOLPHOT in one or two filters can recover a pure sample of stars. Conversely, colors formed between short-wavelength and long-wavelength filters can be used to effectively identify pure samples of galaxies. Our results highlight that the existing DOLPHOT output parameters can be used to reliably classify stars in our NIRCam data without the need to resort to external tools or more complex heuristics.
Early Infrared and Visible Spectra from the 2022 Outburst of the Recurrent Novae U Scorpii
Authors: Rudy Richard J. , Subasavage John P. , Mauerhan Jon C. , Nofi Larissa 
Published: February 2023

Abstract
Spectroscopy from 0.46–2.5 μm is presented for the 2022 outburst of the recurrent nova U Scorpii from 2.54, 3.60, and 8.59 days after maximum light. During this period the spectra evolved from comparatively low excitation to the verge of displaying coronal lines. Between days 2.54 and 3.60, the nova showed a marked decrease in the low excitation lines of N i, O i, and Mg ii , an increase in He i, the emergence of N iii, and changes to the very broad line profiles. By day 8.59, the He i lines had been largely replaced by He ii emission and most broad component were weak or undetectable. No optical coronal lines were observed during or immediately following the detection of infrared coronal lines by Banerjee et al.
Gouverner une assemblée citoyenne . Le rôle du Comité de gouvernance de la Convention citoyenne pour le climat
Authors: Fourniau Jean-Michel 
Published: February 2023

« Qui gouverne une assemblée citoyenne ? » La question vise les conditions qui permettraient de pérenniser et d’institutionnaliser ce type d’exercice démocratique. Cet article en témoigne : en France, même les approches qui voient dans les assemblées citoyennes tirées au sort une nouvelle forme de représentation démocratique ont répondu à cette question selon les schèmes anciens de la participation du public. Ceux-ci ont conduit à penser la « souveraineté » de la Convention citoyenne pour le climat (CCC) dans les termes d’un pilotage indépendant de l’exécutif, et non comme la prérogative d’un Parlement des citoyen·nes. Les travaux internationaux sur les mini-publics abordent quant à eux la question en termes d’autonomie de la délibération citoyenne, qui doit être protégée par des règles de fonctionnement et encouragée par l’animation. Cela conduit à des dispositifs très différents, concentrant en France dans un comité de gouvernance les fonctions de pilotage stratégique, de conseil scientifique et d’organisation, plus souvent distribuées à l’étranger entre différentes instances. Cet article retrace la genèse et certains aspects du fonctionnement du Comité de gouvernance de la CCC. Son fil directeur est de considérer que les enjeux de pouvoir révélés par le pilotage et l’organisation d’une assemblée citoyenne engagent le regard que l’on porte sur ces exercices – participation à l’élaboration des décisions publiques ou fabrique de la loi –, qui conditionne à son tour la manière d’aborder leur gouvernance.
La Convention citoyenne pour le climat : un dispositif hors norme parmi les assemblées citoyennes sur le climat ?
Authors: Smith Graham , Fourniau Jean-Michel , Deshautel Lise 
Published: February 2023

La Convention citoyenne pour le climat, qui s’est tenue en France entre 2019 et 2021, se situe au sommet de ce que l’OCDE appelle la « vague délibérative ». Si elle présente un fort air de famille avec les autres assemblées climatiques, cela peut masquer des différences significatives. En comparant la Convention avec les cinq autres assemblées nationales pour le climat qui ont achevé leurs travaux à la fin de 2021, l’unicité du phénomène des assemblées pour le climat est remise en question. Grâce à cette comparaison, il apparaît clairement que certains aspects de la commande, de la gouvernance, de la conception et de l’impact de la Convention citoyenne pour le climat la distinguent des autres assemblées climatiques. Il s’agit d’une « donnée aberrante » en termes de sciences sociales. Et ce statut d’exception peut jouer un rôle important dans la remise en question des principes établis pour la pratique des mini-publics délibératifs.
Abstract 106
Authors: Jamwal Juhi 
Published: February 2023

Case Report: A 45 years male married with 3 kids, former smoker and no underlying comorbidities presented to medical emergency with sudden onset heaviness of head in occipital area and lightheadedness at around 8 pm. It was followed by excessive generalised sweating and altered sensorium in the form of unresponsiveness that lasted for 5- 10 minutes. During same period he developed urinary incontinence. He had no episode of abnormal body movements. His Blood pressure was 140/100 mmHg, GCS was 15/15, Pupils Bilateral normal size with reaction to light present. Systemic examination was normal. Random Blood glucose was 92 mg/dl. Noncontrast CT brain was advised that showed 13.8 X 9.3 mm well- delineated hyperdense lesion in the region of sella [Fig. 1] with Subarachnoid haemorrhage. MR angiography was done that showed narrow neck giant aneurysm at C5 segment of distal ICA and ophthalmic artery is arising from base of the aneurysm. Cerebral angiogram was performed that confirmed the findings and after that balloon assisted coiling of aneurysm was done and flow diverter was placed across left Internal carotid artery – terminal [ophthalmic] segment. Check angiogram revealed no filling or recurrence of aneurysm with good filling of ophthalmic artery. He developed transient mild hyponatremia post procedure and got improved with normal saline.
After 15 days from discharge from hospital, he started with dryness of mouth, increase in thirst and craving for cold water. Also he noticed increased frequency of micturition so much so that he had to get up 4-5 times during night to pass urine. His appetite also decreased. No associated nausea or vomiting. He also developed cold intolerance and erectile dysfunction over one-and-a-half-month period. With these complaints, he visited Outpatient department. Hormone evaluation revealed, Total T4 7.63 mcg/dl, Cortisol 0.72 mcg/dl, FSH 1.23 IU/L, LH 0.87 IU/L, Testosterone 28.28 ng/dl, Prolactin 16.74 ng/ml, Serum Sodium 148, Potassium 3.78, 24 hour urinary volume 4.5 litres. Serum osmolality 304 mosml/l, Urine osmolarity 121 mosm/l. He was started on prednisolone 5 mg, Thyroxine 50 mcg, Desmopressin 0.1 mg bedtime and testosterone injections 100 mg Intramuscular every 21 days. He noticed improvement in his symptoms within 3 days of starting treatment and hypernatremia also settled. Contrast MRI sella was done after 3 months from procedure and noted 15 X 10 mm T1/T2 hypointense area in suprasellar location likely thrombosed aneurysm causing mass effect on pituitary stalk and pituitary bright spot not seen.
Abstract 121
Authors: Ali Syed Farooque , Sunanda T , Vijaya Sarathi H A , Anudeep G , Rakesh Venkata , Ravindra Shruthi 
Published: February 2023

Introduction: Neonatal Diabetes mellitus in first 6 months of life is usually monogenic and is usually referred to as neonatal diabetes mellitus. The incidence of neonatal diabetes is extremely rare and varies from 1:89000 to 1:400000 live births. The most common cause of permanent neonatal diabetes is heterozygous activating mutation in the KCNJ11 gene encoding kir 6.2.

Case Report: we report a 1 month 25 days male infant presented to our hospital with complaints of excessive inconsolable cry, up rolling of eyes, staring look, difficulty in breathing, refusal of feeds and repeated seizures, diagnosed outside as diabetic ketoacidosis (GRBS- 600 mg/dl, PH- 6.96, HCO3- 2.1, PCO2- 10) and managed accordingly with IV fluids, insulin and antiepileptic. Referred to our hospital for further management. On evaluation diagnosed as neonatal DM. 4th hourly GRBS was done and insulin Glargine given as basal regimen. Bolus doses of regular insulin was given based on GRBS. C peptide levels were low. Genetic study revealed heterozygous missense variation in exon1 of KCNJ11 gene (pArg201Cys).
After genetic analysis baby was admitted to change over from insulin to sulfonylurea treatment. The patient was put on CGMS (Medtronic) on day2 of admission. Baby was started on Tab. Glibenclamide (0.1 mg/kg/dose) BD and gradually increased to 1 mg/kg/dose BD. Gradually regular insulin was tapered to 0.5 units sos and Inj. Glargine was reduced from 3 units BD to 0.5 units BD and blood sugars were under control.
He was gradually transitioned from insulin to glibenclamide. He is presently 3.5 years with a weight of 12 kgs and height of 94.5 cms. He is presently in good glycaemic control, with the tablets being given twice a day.

Conclusion: This genetic diagnosis has therapeutic implications as patients can switch from insulin therapy to sulphonylurea, as described in this case report. Most of the children with a KCNJ11 gene mutation have an overall good prognosis with good glycaemic control attained with oral sulphonylurea therapy.
Abstract 153
Authors: Phadte Aditya , Memon Saba , Budyal Sweta , Patil Virendra , Lila Anurag , Bandgar Tushar 
Published: February 2023

Background: Gonadotropin-dependent precocious puberty (GDPP) is the most common cause of precocious puberty. Data on GDPP from Indian subcontinent is scarce.

Objectives: We aim to describe single centre experience of patients with GDPP.

Methods: The clinical, biochemical features and therapeutic outcomes of patients presenting with diagnosis of GDPP from Jan 2000 to July 2021 were analyzed.

Results: 78 patients (girls, n = 61, 78.2%) with GDPP were included. The median age of pubertal onset (29 vs. 75 months) and age at presentation (58 vs. 82 months) was earlier in boys than in girls. The commonest presenting symptom was genitalia growth (76.47%) in boys and breast development (75.4%) in females, followed by height spurt (boys: 17.6%, girls: 11.4%), pubic hair development (boys: 5.8%, girls: 6.5%) and vaginal bleeding (6.5%). The height at presentation and target height SDS were 1.02 and -0.77 in males and 0.75 and -0.82 in females, respectively.
In boys, median (range) basal serum FSH, LH and testosterone were 2.48 mIU/ml (0.42-5.7), 2.6 mIU/ml (0.52-10.01), and 3.75 ng/ml (0.1-8.27) respectively. In girls, the median (range) basal serum FSH and LH were 5.24 mIU/ml (1.03-19.8) and 2.2 mIU/ml (0.05-15.8); basal serum LH being <0.3 mIU/ml was seen in 11 females. The median post gonadotropin stimulated peak serum LH in the latter 11 females (age range: 82-99 months) was 9.37 mIU/ml (range: 5.42-19 mIU/ml). At 60 minutes, all except one patient reached a stimulated serum LH value of ³ 5 mIU/ml. The median (range) difference in bone age and chronological age was 33 months (-2.0 to 98) and 2.5 months (4.0 to 76) in boys and girls, respectively. Ultrasonogram pelvis was available for 38 females. Uterine length ³ 3.2 cm was found in 84.2% of patients.
In boys, precocity-related MRI brain abnormality was seen in 80% whereas it was found in 23.6% of girls. Fifty-five patients were treated with injection leuprolide acetate depot [monthly 3.75 mg per (n = 2) or 7.5 mg (n = 1), three monthly 11.25 mg (n = 27) or 22.5 mg (n = 25)] whereas five patients were treated with triptorelin. Only one girl had an allergic reaction to leuprolide and was switched to triptorelin. In males, final height SDS was 0.16 (n = 2); in females, final height SDS was -0.25 (n = 20). MPH SDS in treated patients were -0.38 and -0.86 in boys and girls, respectively.

Conclusion: GDPP was more common in girls. Post gonadotropin stimulated peak serum LH ³5 mIU/ml at60 min aids in diagnosis in those with LH £0.3 mIU/ml. GnRH therapy helps in reducing height loss.
Abstract 172
Authors: Bishnoi Alka 
Published: February 2023

Introduction: Dent’s disease is a rare X-linked renal tubulopathy characterized by low-molecular-weight proteinuria, hypercalciuria, nephrocalcinosis, nephrolithiasis, and progressive renal failure. Common features are rickets or osteomalacia, growth retardation, and short stature. Short staturein children suffering from this diseasecould be multifactorial, including rickets, GH resistance, reduced GH secretion rate or functional IGF deficiency and increased IGFBP. To the best of our knowledge, this is only the fourth report on the use of growth hormone therapy in a child with poor growth associated with Dent’s disease. We report two siblings with Dent’s disease and growth failure who responded to growth hormone (GH) treatment.

Summary: Initially the elder sibling presented at the age of five yearsto pediatrics with proteinuria, calciuria, phosphaturia and growth failure and was treated with calcium, vitamin D and multivitamin supplementation and ACE inhibitor. During evaluation foretiology of renal wasting, genotyping revealed ahemizygous two base pair duplication in exon 6 of the CLCNS gene resulting in frame-shiftmutation. Laterthe younger sibling presented with similar features and hence he was also subjected to genotyping which revealed same mutation along with parents being carriers. Both were referred to us for short stature at a chronological age of 11 years (younger) and 15 years (older). Evaluation revealed GH deficiency (IGF 49.21 ng/ml range 37-459) in the younger brother but elder brother had normal GH-IGF axis along with features of Rickets and nephrocalcinosis in both brothers. Bone-age was delayed in both, 4.5 years and 11 years respectively. Literature search revealed three different cases of short stature where GH therapy had been tried with success. Hence GH therapy was started at the dose of 0.18 mcg/kg/week in both along with vitamin D, potassium, phosphorous supplements and thiazide diuretic. After 1 year of GH treatment, height increased from 113 cm (−4.1 S.D.) to 121.5 cm (− 3.5 S.D.) in younger one and 139 cm (-3.5 SD) to 148 cm (-2.7 SD) in the elder brother. IGF-1 levels increased in the younger one from 49.2 ng/ml (37-459) to 191 ng/ml. Bone age also increased from 4.5 years to 6.5 years in the younger one and from 11 years to 13 years in the elder sibling. Our preliminary findings showed beneficial effects of GH treatment on growth velocity of around 8 cm in younger sibling and 9 cm in elder sibling after one year.
GH treatment should be considered in children with Dent’s disease and short stature since positive effects on linear growth can be obtained.
Abstract 42
Authors: Thomas Glady , Divyasri Namburi , Verma Padmanabha , Kunnuru Sumana , Anne Beatrice 
Published: February 2023

Introduction: Dyggve-Melchior-Clausen syndrome (DMC) is a rare, progressive genetic disorder characterized by abnormal skeletal development, microcephaly and intellectual disability. It involves mutation of Dymeclin (DYM) gene on chromosome 18q12.1 that encodes for DYM protein which is expressed in cartilage, bone, and brain.

Case Discussion: Child aged 9 years with complains of failure to gain height-since infancy with intellectual disability. Child developed generalized joint pains since-4 years. Born as the first child to a second-degree consanguineous marriage. Oligohydramnios was diagnosed in second trimester and was delivered at 34 weeks by LSCS due to PPROM. Birth weight was 2 kg and APGAR was 9. Developmental milestones were delayed. Child has impaired speech and behavioral abnormalities like aggressive behavior, self harming tendencies, hyperactivity, poor attention span and temper tantrums. Younger sibling expired at the age of 3 months due to recurrent vomiting and seizures. Anthropometry showed height of117 cm (Ht SDS -2.09) and weight of 24 kg (25-50 percentile). US/LSratio-1.02, Arm span-119.5 cm, Head circumference-48.8 cm (-2SDS), Mid-parental height unable to assess as father is abroad. There was short forehead, flat occiput, large ears, poor dental hygiene, deformities of hands, widened wrists, short broad fingers, knock knees and widened ankle joint. Spinal examination showed kyphosis in upper back, exaggerated lordosis in lower back. Gait was of waddling nature.
Laboratory evaluation showed hemogram was within normal limits. Calcium-9.9 mg/dl. Phosphorus-4.9 mg/dl, Alkaline phosphatase-299 IU. Creatinine-0.34 mg/dl.TT3-1.70 ng/ml, TT4-4.7 m/dl, TSH-1.56 mIU/ml. VIT D—29.12 ng/ml, S.PTH—38.2 pg/ml. C spine Xray suggestive of atlantoaxial dislocation. Thoraco-lumbo-sacral spine showed decreased vertebral body height, central notching and beaking of superior and inferior end plates. Hand x ray showed small metacarpals and enlarged epiphysis of distal radius and ulna. Pelvic Xray showed bilateral small iliac wing, lacy appearance of iliac crests, multiple small translucent areas in pelvic rami, symmetric enlargement of femoral heads on lateral aspect and displaced laterally. Leg Xray showed enlarged medial epiphysis of distal femur, tibia and irregularities of metaphyses. Karyotyping-46XY. Genetic analyses revealed homozygous mutation of DYM gene on exon7 of chromosome 18–autosomal recessive suggestive of DYGGVE MELCHIOR CLAUSEN DISEASE. Mother had a pericentric inversion of chromosome 9.

Conclusion: This is a rare case of Dyggve Melchior-Clausen syndrome with typical features of skeletal dysplasias and intellectual disability. Patient is being planned for atlanto-axial stabilisation surgery. Genetic counselling given to parents.
Abstract 56
Authors: Parekh Tapan D. , Chakraborty Partha Pratim , Bhattacharjee Rana , Sinha Anirban , Maiti Animesh 
Published: February 2023

Introduction: Camurati-Engelmann disease (CED) also known as progressive diaphyseal dysplasia, is a rare autosomal dominant type of bone disease with variable penetrance. It belongs to the group of sclerosing bone dysplasia and is due to increased intramembranous bone formation.

Case Presentation: A 5 yr old boy presented with complain of recurrent fractures following trivial trauma since 9 months age. Most common site of fracture is left tibia and other fractures were also in lower limb. Patient also complains of progressive gait abnormality since age of 2.5 yrs. Patient was born out of nonconsanguineous union at term by normal vaginal delivery with unremarkable birth history. No history of similar complains in other family members. On examination, there is deformity of both lower limb (left > right). There is no blue sclera, hearing loss, spinal deformity, rachitic features or proximal myopathy.

Investigation: X ray (skeletal survey)- Bilateral and symmetrical cortical thickening of diaphysis of long bones. Epiphysis and metaphysis are spared. No osteosclerosis at skull base, mandible and axial skeleton. Relevant biochemical and hormonal investigations are normal.
Bone scintigraphy showing increased tracer uptake in shaft of both femur, tibia and proximal part of both forearm. Based on clinical and radiological finding diagnosis of CED is made (mutational analysis report is pending).

Discussion: CED is rare genetic disorder, most cases due to TGFβ1 gene mutation. The presenting symptoms include pain in extremities, waddling gait, muscle weakness and rarely hearing loss. The hallmark of the disorder is bilateral symmetrical cortical thickening of the diaphyses of the long bones with sparing epiphysis. Several reports have described successful treatment with short-term corticosteroids.