bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of cytotoxic and apoptotic activities of the Cassia angustifolia aqueous extract against SW480 colon cancer
Authors: Momenah Maha Abdullah , Alqahtani Alaa Ali , AL Qassim Fatima Abdullah , Alotaibi Amani Mohammed , Albasher Gadah , Al-Qahtani Wedad Saeed 
Published: May 2023

Abstract
The current natural extract modalities for colorectal cancer are limited. This research seeks to assess the process of extracting the plant’s bioactive constituents from Cassia angustifolia and to show the anticancer role played by the plant’s aqueous extract at 0°C by identifying the genes that alter in expression after the Cassia angustifolia treatment in colon cancer cells. The bioactive components of Cassia angustifolia extract were revealed using gas chromatography-mass spectrometry analysis. The colon carcinoma cell lines (SW480) were treated with Cassia angustifolia macrophages at concentrations of 50, 150, and 200 µg/mL for 48 h. Apoptosis was examined by fluorescence-activated cell sorting analysis of Cassia angustifolia-treated and -untreated cells. Microarray analysis was performed by using human microarray chips (HG-U95A) for untreated and treated SW480 cells. Microarray data were confirmed by the reverse transcription polymerase chain reaction. The findings showed that the Cassia angustifolia aqueous extract at 0°C/24 h contained the entire absolute phenolic content of 28.43 mg/g and the entire absolute flavonoid content of 9.16 mg/g. Cassia angustifolia enhanced the hindrance of cell development and apoptosis and decreased glucose uptake. Western blot analysis showed induction in the expression of cleaved caspases 3 and 9 in SW480 cells. Microarray data identified 11 genes and 7 expressed sequence tags (ESTs) markedly altered in treated vs non-treated SW480 cells. Several of these genes have been embroiled in multiple malignancies. In conclusion, the current study provides remarkable new data for Cassia angustifolia extracted at 0°C/24 h. We discovered 7 ESTs and 11 genes that are significantly altered in the progression of SW480 cells treated with Cassia angustifolia therapy versus no treatment, with anticancer and apoptosis inducer effects.
Impact of using a predictive neural network of multi-term zenith angle function on energy management of solar-harvesting sensor nodes
Authors: Al-Omary Murad , Aljarrah Rafat , Albatayneh Aiman , Alshabi Dua’a , Alzaareer Khaled 
Published: May 2023

AbstractUsing the Neural Networks to predict solar harvestable energy would contribute to prolonging the duration of the effective operation and thus less consumption in solar-harvesting sensor nodes. The NNs with higher prediction accuracy have the longest effective operation. Till now, the NNs that use the zenith angle function as input have been utilized with only two terms. This paper shows the advantages of using a multi-term zenith angle function on the energy management in the nodes. To this end, this paper considers two, three, and four terms for the function of the zenith angle. The results showed that the case of four terms has the lowest prediction mistakes on average (0.83%) compared to (2.13% and 1.75%) for the cases of two and three terms, respectively. This is followed by a reduction in energy consumption in favor of four terms case. For one month simulation period with hourly prediction, the sensor node worked at the higher consumption mode (M2) in the case of four terms 4 hours less than three terms and 7 hours less than two terms case. Thus, increasing the number of terms in the zenith angle function leads to higher accuracy and less energy consumption.
Islanding detection and power quality disturbance classification in multi DG based microgrid using down sampling empirical mode decomposition and multilayer neural network
Authors: Choudhury Anasuya Roy , Nayak Pravati , Mallick Ranjan Kumar , Agrawal Ramachandra , Mishra Sairam , Panda Gayadhar 
Published: May 2023

Abstract
Power Quality, Equipment and Personnel safety of any distributed generation (DG) system connected to utility Grid merely depends on accurate detection of Islanding and non-islanding Power quality disturbances. The main objective of the proposed research is to detect islanding events with very narrow non-detection zone (NDZ) and classification of power quality disturbances with higher accuracy using signal processing and intelligent method together. A noise robust down sampling empirical mode decomposition (DEMD) is used to extract signature of islanding and power quality (PQ) disturbance features from the collected voltage signals and multilayer perceptron neural network (MLNN) is proposed to classify islanding and non-islanding (PQ) events. The performance of the proposed (DEMD-MLNN) technique is verified with IEEE-9 bus distributed generation system dominated by solar &wind energy penetration. The simulation work is carried out in MATLAB/Simulink platform. The efficacy of the proposed DEMD-MLNN is verified by large number of numerical experimentations with and without noise and comparing with existing competitive well-known techniques.
Drying Kinetics of American Ginseng Slices in Thin-layer Air Impingement Dryer
Authors: Wang Dong , Dai Jian-Wu , Ju Hao-Yu , Xie Long , Xiao Hong-Wei , Liu Yan-Hong , Gao Zhen-Jiang 
Published: May 2023

Abstract
Thin-layer air impingement drying kinetics of American ginseng slices were investigated under different drying temperatures (35, 40, 45, 50, 55, 60, and 65°C), air velocities (3, 6, 9, and 12 m/s), and sample thicknesses (1, 2, 3, and 4 mm). Results indicated that the drying time is more significantly affected by drying temperature followed by sample thickness and air velocity. Drying rate curves illustrated that the whole drying process happened in the falling rate period. Additionally, from initial drying to the moisture content of about 0.5 kg/kg, the drying rate increased with the increase of drying temperature and air velocity or decreased with the increase of sample thickness. The moisture effective diffusivity (D
eff) was determined both neglecting shrinkage and considering shrinkage. The drying activation energy of American ginseng slices was 46.64 kJ/mol determined by Arrhenius relationship. The moisture effective diffusivity and drying activation energy of American ginseng slices were compared to other biomaterials and related issues were also discussed. The current work is useful for designing air impingement drying system, evaluating and saving energy consumption of American ginseng slices.
Hybrid WDM-PDM visible light communication system incorporating compressed spectrum return to zero advance modulation format
Authors: Turke Mandeep Singh , Lovkesh  
Published: May 2023

Abstract
Hybrid wavelength division multiplexing (WDM) and polarization division multiplexing (PDM) technology is a promising candidate for high capacity and extended reach in visible light communication (VLC) systems. However, multilevel modulations and direct modulation are suffered from two predominant limitations in VLC such as high complexity and frequency chirping respectively. Therefore, in this work, a high-capacity VLC system is presented by employing a hybrid WDM-PDM and compressed spectrum return to zero (CSRZ) advanced modulation format. Moreover, direct modulation is replaced with external modulation employing Mach-Zehndar modulators and red/green/blue (RGB) laser diodes (LDs). A detailed comparison of non-return to zero (NRZ) and CSRZ is performed at varied VLC lengths in terms of bit error rate (BER) and Q factor. Results revealed that CSRZ is far better than NRZ and external modulation offered an edge over direct modulation. The maximum VLC distance achieved using CSRZ is 229 cm within acceptable BER limits (10−3) without forward error correction (FEC).
Trucking (un)limited – the impact of digital platforms on labour in production networks of logistics
Authors: Helwing Veronique , Verfürth Philip , Franz Martin 
Published: May 2023

Abstract
For many years, struggles over value capture have been taking place between different actors in the logistics sector, creating ever more pressure for workers in traditional activities of logistics. New actors, in the form of digital business-to-business (B2B) platforms, which are proliferating especially in the freight transport sector, are further challenging the already contested field. Based on the Global Production Networks (GPN) approach, this study addresses the question of how B2B platforms affect labour in production networks of logistics, and what labour agency practices are emerging in the face of advancing platformisation. The study draws on interviews with various actors operating in the road freight transport sector in Germany. The results show that digital B2B platforms, due to their intermediary function, have a direct impact on the inclusion and exclusion of actors involved in production networks of logistics, and induce not only a race to the bottom in terms of labour conditions, but also produce increasingly contingent geographies of logistics. This paper contributes to the literature on platforms by examining previously neglected B2B platforms and shedding light on the different ways that labour in global production networks can be affected by new agents, such as digital platforms.
VENTRA – ESTADOS DE MOVIMENTOS
Authors: Fogaça Lopes Pâmela 
Published: May 2023

Resumo: Relato da produção da vídeo-performance Ventra – estados demovimentos realizada pelos alunos do Programa de Mestrado em Artes Visuais da Universidade Federal de Pelotas - UFPel, 2019, Pelotas/RS, Brasil.Palavras-chave: Vídeo-performance; Improvisação; Composição. VENTRA - MOVEMENT STATESAbstract: This is a report on the production of the video-performance Ventra - states of movements carried out by the students of the Graduate Program in Arts - Master in Visual Arts at the Federal University of Pelotas - UFPel, 2019, Pelotas/RS, Brazil.Keywords: Video-performance; Improvisation; Composition.
Porque esperamos [notas sobre a docência, a obsolescência e o vírus]
Authors: Bedin da Costa Cristiano 
Published: May 2023

[RESENHA DE LIVRO] Porque esperamos [notas sobre a docência, a obsolescência e o vírus] / Angélica Vier Munhoz, Cristiano Bedin da Costa, Sergio Andrés Lulkin (organizadores). 1.ed. – Porto Alegre: UFRGS, 2020. Disponível em: https://lume.ufrgs.br/handle/10183/210654Palavras-chave: Esperar; Docência; Vírus. Why we wait [notes on teaching, obsolescence and the virus] Abstract: [BOOK REVIEW] Why we hope [notes on teaching, obsolescence and the virus] / Angélica Vier Munhoz, Cristiano Bedin da Costa, Sergio Andrés Lulkin (orga­nizers). 1.ed. - Porto Alegre: UFRGS, 2020. Available at: https://lume.ufrgs.br/hand­le/10183/210654.Keywords: Waiting; Teaching; Virus.
A coordinated multiorgan metabolic response contributes to human mitochondrial myopathy
Authors: Southwell Nneka , Primiano Guido , Nadkarni Viraj , Attarwala Nabeel , Beattie Emelie , Miller Dawson , Alam Sumaitaah , Liparulo Irene , Shurubor Yevgeniya I , Valentino Maria Lucia , Carelli Valerio , Servidei Serenella , Gross Steven S , Manfredi Giovanni , Chen Qiuying , D'Aurelio Marilena 
Published: May 2023

AbstractMitochondrial diseases are a heterogeneous group of monogenic disorders that result from impaired oxidative phosphorylation (OXPHOS). As neuromuscular tissues are highly energy‐dependent, mitochondrial diseases often affect skeletal muscle. Although genetic and bioenergetic causes of OXPHOS impairment in human mitochondrial myopathies are well established, there is a limited understanding of metabolic drivers of muscle degeneration. This knowledge gap contributes to the lack of effective treatments for these disorders. Here, we discovered fundamental muscle metabolic remodeling mechanisms shared by mitochondrial disease patients and a mouse model of mitochondrial myopathy. This metabolic remodeling is triggered by a starvation‐like response that evokes accelerated oxidation of amino acids through a truncated Krebs cycle. While initially adaptive, this response evolves in an integrated multiorgan catabolic signaling, lipid store mobilization, and intramuscular lipid accumulation. We show that this multiorgan feed‐forward metabolic response involves leptin and glucocorticoid signaling. This study elucidates systemic metabolic dyshomeostasis mechanisms that underlie human mitochondrial myopathies and identifies potential new targets for metabolic intervention.
Verbesserung der Bedingungen für einen effizienteren biologischen Abbau von Molekülen
Authors: Tolnai Béla 
Published: May 2023

Bei der biologischen Wasserreinigung werden die Schadstoffmoleküle mit Hilfe von Enzymen abgebaut. Der Prozess kann in zwei aufeinander folgende Teilprozesse unterteilt werden. Die Trennung basiert auf den Phänomenen außerhalb des Biofilms und innerhalb des Biofilms. Außerhalb des Biofilms ist der Stofftransport der dominierende Faktor. Im Inneren des Biofilms herrschen die Gesetze der Biochemie.
Eine Verbesserung der Bedingungen für die Verschlechterung ist möglich, indem die Parameter der Beziehungen, die das Phänomen beschreiben, manipuliert werden. Insbesondere kann die Nährstoffversorgung von Biofilmen kontrolliert werden. Der quantitative Zustand der Nährstoffversorgung wird durch die Pe-Zahl (Peclet) charakterisiert, deren optimaler Wert bei Pe = 1 liegt. Bei der Partikelfiltration ist Pe = 10 der typische Wert, bei der biologischen Filtration unter künstlichen Bedingungen können jedoch um Größenordnungen höhere Werte erreicht werden. Die Abwasserbehandlung ist einer der Prozesse mit einem hohen Pe-Zahl. Bei der Verbesserung der Effizienz der Abwasserreinigung besteht das Ziel der Maßnahmen darin, den Pe-Zahl zu senken.
Derzeit gibt es kaum Möglichkeiten, das Geschehen innerhalb des Biofilms zu beeinflussen. Aber diese spontanen Prozesse sind ein wichtiger Bestandteil der biologischen Wasserreinigung.
Emergency department management for an unusual case of penile entrapment and strangulation
Authors: Ramawad Hamzah A. , Rhodes Adam 
Published: May 2023

A 11-year-old boy was seen at our pediatric emergency department (PED) for evaluation of a swollen and painful penis. He had placed a glass ring over his penis fourteen days prior. This resulted in straining with micturition and a fleshy circumferential non healing wound at the base of the penis with serosanguinous discharge. The glass ring eroded into the deep subcutaneous layer of the skin at the base of the penis. The distal penis was swollen and tender with no changes in skin color, texture or blurring of sensation. The glans was viable with appropriate capillary refill. Urine stream was unaffected, and the amount of serosanguinous discharge was not related to the act of voiding. Emergency measures were conducted including administration of analgesia, antiemetics, active immunization against tetanus, systemic antibiotic therapy (cefazolin), and urology consultation. Due to extensive damage, urology deferred ring removal in the PED and recommended removal in the operating room to control the probable damages better, post removal of ring. The patient was transferred as our facility did not have an inpatient unit for post operative management. The ring was successfully removed using a bone cutter under general anesthesia. Surgical exploration revealed minimal erosion into the cavernosal bodies without any injuries to the dorsal veins, dorsal and deep artery, and nerves. Intra-op cystoscopy showed no injuries to the urethra. Primary closure was done circumferentially in two layers (Buck’s fascia and skin) with an absorbable vicryl 5-0 interrupted suture, followed by pressure bandage. The case was presented to a social worker considering the clinical features of the case. The social service experts and providing physicians were reassured there was no concerns for child abuse, sexual abuse, neglect, behavioral or psychiatric disorders. The patient was discharged with Bactrim and analgesics for one week after he was able to void independently. One month follow up at the urology clinic revealed that the patient had good skin preservation, wound healing, and micturition. The patient had no difficulties with anxiety, depression, or post-traumatic stress at his follow up appointments with a behavioral health therapist.
Comparative Evaluation of the level of contamination of internal hospital surfaces, using two methods: nano biosensor and microbial culture
Authors: Ekrami Ali , Hosseini Mohammad Ali , Ekrami Hasan 
Published: May 2023

Abstract
Background: Today, out of every 5% to 10% of patients admitted to the hospital, one patient is involved in the complications of hospital infections, which has been confirmed to be directly related to the spread of these infections with the contamination of hospital surfaces. Therefore, it is very important to use an efficient method to identify microbial contamination. To this end, this study was carried out to compare the level of contamination of indoor hospital surfaces using two methods of dye detector nanosensor and microbial culture medium (traditional method).
Method: The present descriptive study was carried out with a sample size of 400 cases on ten types of medical equipment for three months using dye detector nanosensor and microbial culture medium. The results were reported as clean and contaminated.
Results: According to the results, 44% of the samples of microbial culture medium and 45.5% of nanosensor samples were reported positive (contaminated). The samples obtained from static microbial culture, ventilator, and the samples obtained from nanosensor, static, and pulse oximetry were identified as the most contaminated surfaces. Also, E. coli (55.68%), Staphylococcus aureus (28.9%), and Salmonella (23.86%) were recognized as the most common microorganisms.
Conclusion: The amount of contamination detected by both methods is acceptable due to the high sensitivity of both methods and lack of sterile surfaces. Therefore, in cases where only the detection of general contamination is considered, not isolation of bacteria, dye detector nanosensors can be used as a rapid method to control the contamination of surfaces instead of traditional methods.
The level of corona anxiety in mothers with children suffering from cancer and other diseases referring to Shahid Sadoughi Hospital in Yazd during the covid 19 pandemic
Authors: Pourmovahed Zahra , Azimi Mahya , Sadeghian Amir Mohammad , Roozbeh Behzad , Ardian Nahid 
Published: May 2023

Introduction: This study was conducted to compare Covid-19 anxiety in mothers with cancer children and mothers with children who have other diseases during the Covid-19 pandemic.
Methods: This was a descriptive-analytical and cross-sectional study conducted on 250 mothers with cancer children and mothers with children who have other diseases. They visited the clinic and oncology department of Shahid Sadoughi Hospital in Yazd in 1400.
Convenience sampling method was used. Data collection tools were demographic information and Covid-19 anxiety questionnaires. Data were analyzed with a confidence level of 95%.
Results: The mean anxiety score of mothers of children with cancer was 36.36±11.16. The mean anxiety score of mothers of children with other diseases was lower ( 34.65±10.82), based on the t-test statistical test, but no significant difference was statistically observed between them.
Conclusion: Findings showed that, in general, the average anxiety of mothers in both groups was high (more than 30 out of 54), but there was no significant difference between them regarding the anxiety score.
More studies should be done in different situations and times to more precisely determine the factors affecting the intensity of anxiety of mothers with cancer children .
Ocena korozji stali podczas geologicznej sekwestracji dwutlenku węgla
Authors:   Instytut Nafty i Gazu – Państwowy Instytut Badawczy, Masłowski Mateusz 
Published: May 2023

W artykule przedstawiono tematykę związaną z korozją stali podczas geologicznej sekwestracji dwutlenku węgla. Ma to związek z tworzeniem się środowiska korozyjnego w obecności wody w środowisku CO2. Następuje wówczas pogorszenie się właściwości stali w wyniku jej reakcji z otaczającym środowiskiem i przechodzeniem wolnego metalu w związki, co wpływa w znacznym stopniu na bezpieczeństwo pracy urządzeń oraz stan rur stalowych. Opracowaną procedurę symulacji zjawiska korozji, metodykę badań, analiz i oceny korozji zweryfikowano testami laboratoryjnymi. Do testów zastosowano próbki stali L-80 (13Cr) wycięte z rury eksploatacyjnej. Natomiast środowisko korozyjne stanowił wilgotny czysty dwutlenek węgla o zawartości wody destylowanej wynoszącej 5000 ppm. Testy korozji przeprowadzono dla dwóch temperatur (40°C i 80°C) i dwóch ciśnień (8 MPa i 20 MPa), umożliwiających uzyskanie CO2 w fazie nadkrytycznej. Na podstawie wykonanych fotografii powierzchni stali nie stwierdzono widocznej korozji. Po testach korozji powierzchnie kuponów miały nadal charakter metaliczny, błyszczący. Wyznaczone na podstawie ubytku masy wartości szybkości korozji także nie wykazały procesu korozji stali w środowisku zawilgoconego CO2 dla zadanych warunków T i P. Dodatkowo wykonane obrazowanie i analiza powierzchni stali pod mikroskopem optycznym pozwoliły na zaobserwowanie początku tworzenia się korozji ogólnej (równomiernej) i wżerowej (miejscowej). Określono wielkości charakteryzujące wżery (średnią i maksymalną głębokość). Głębokość powstałych wżerów była rzędu od 0,00569 mm do 0,017 mm. Największą głębokość uzyskano w teście 4 (T = 80°C i P = 20 MPa). Na tej podstawie wyznaczono wartości szybkości korozji oraz wykonano dodatkową teoretyczną analizę głębokości korozji po 1 roku, 10, 50 i 100 latach. Pozwoliła ona stwierdzić, że niebezpieczna głębokość wżerów dla stali L-80 (13Cr) pojawi się po okresie 10 lat.
Protective role of Nigella sativa oil against cisplatin-induced ototoxicity: a literature review
Authors: Hendriyanto Donny , Helmi Helmi 
Published: May 2023

Cisplatin is widely used for the chemotherapy of head and neck cancer. However, it has a significant ototoxicity. Nigella sativa has been scientifically proven to have numerous benefits included to prevent adverse effect of a drug. This literature review aimed to evaluate the protective role of N. sativa oil against cisplatin-induced ototoxicity. Relevant publications were searched from PubMed and Google Scholar databases within the last 10 years. Ototoxicity due to cisplatin can occur through the intrinsic and extrinsic pathways. Cisplatin causes endoplasmic reticulum stress, DNA damage, increased reactive oxygen species (ROS) and inflammatory processes, resulting in increased apoptosis of cochlear outer hair cells. The active constituents of N. sativa including flavonoids, phenolics and thymoquinone can prevent the cisplatin-induced ototoxicity. Examination of endogenous antioxidants, antiapoptotic, and proinflammatory could be used as primary approach to evaluate the protective role of N. sativa against cisplatin-induced ototoxicity.