bluuebunny/crossref_metadata_2025_split huggingface dataset:
Defect Engineering Activates Schottky Heterointerfaces of Graphene/CoSe2 Composites with Ultrathin and Lightweight Design Strategies to Boost Electromagnetic Wave Absorption
Authors: Ding Jiawei , Shi Rongrong , Gong Chuangchuang , Wang Chenxu , Guo Yue , Chen Tong , Zhang Yijing , Cong Hongwei , Shi Chunsheng , He Fang 
Published: September 2023

AbstractTo tackle the increasingly complex electromagnetic (EM) pollution environment, the application‐oriented electromagnetic wave (EMW) absorption materials with ultra‐thin, light weight and strong tolerance to harsh environment are urgently explored. Although graphene aerogel‐based lightweight EMW absorbers have been developed, thinner thickness and more effective polarization loss strategies are still essential. Based on the theory of EMW transmission, this work innovatively proposes a high attenuation design strategy for obtaining ultra‐thin EMW absorption materials, cobalt selenide (CoSe2) is determined as animportant part of ultra‐thin absorbers. In order to obtain a dielectric parameter range that satisfies the ultra‐thin absorption characteristics and improve the lightweight properties of EMW absorption materials, a composite of CoSe2 modified N‐doped reduced graphene oxide (N‐RGO/CoSe2) is designed. Meanwhile, the controllable introduction of defect engineering into RGO can activate Schottky heterointerfaces of composites to generate a strong interfacial polarization effect, achieving ultra‐thin characteristics while significantly improving the EM loss capability. In addition, infrared thermal images and anti‐icing experiments show that the composite has good corrosion resistance, infrared stealth, and thermal insulation properties. Therefore, this work provides an effective strategy for obtaining thin‐thickness, light‐weight, and high‐performance EMW absorption materials, embodying the advantages of N‐RGO/CoSe2 composites in practical applications.
Injectable Shear‐Thinning Hydrogels with Sclerosing and Matrix Metalloproteinase Modulatory Properties for the Treatment of Vascular Malformations
Authors: Zehtabi Fatemeh , Gangrade Ankit , Tseng Kaylee , Haghniaz Reihaneh , Abbasgholizadeh Reza , Montazerian Hossein , Khorsandi Danial , Bahari Jamal , Ahari Amir , Mohaghegh Neda , Hosseinzadeh Kouchehbaghi Negar , Mandal Kalpana , Mecwan Marvin , Rashad Ahmad , Roberto de Barros Natan , Byun Youngjoo , Ermis Menekse , Kim Han‐Jun , Khademhosseini Ali 
Published: September 2023

AbstractSac embolization of abdominal aortic aneurysms (AAAs) remains clinically limited by endoleak recurrences. These recurrences are correlated with recanalization due to the presence of endothelial lining and matrix metalloproteinases (MMPs)‐mediated aneurysm progression. This study incorporates doxycycline (DOX), a well‐known sclerosant and MMPs inhibitor, into a shear‐thinning biomaterial (STB)‐based vascular embolizing hydrogel. The addition of DOX is expected to improve embolizing efficacy while preventing endoleaks by inhibiting MMP activity and promoting endothelial removal. The results show that STBs containing 4.5% w/w silicate nanoplatelet and 0.3% w/v of DOX are injectable and have a twofold increase in storage modulus compared to those without DOX. STB‐DOX hydrogels also reduced clotting time by 33% compared to untreated blood. The burst release of DOX from the hydrogels show sclerosing effects after 6 h in an ex vivo pig aorta model. Sustained release of DOX from hydrogels on endothelial cells shows MMP inhibition (approximately an order of magnitude larger than control groups) after 7 days. The hydrogels successfully occlude a patient‐derived abdominal aneurysm model at physiological blood pressures and flow rates. The sclerosing and MMP inhibition characteristics in the engineered multifunctional STB‐DOX hydrogels may provide promising opportunities for the efficient embolization of aneurysms in blood vessels.
Advanced Interfacial Design for Electronic Skins with Customizable Functionalities and Wearability
Authors: Tan Di , Xu Bingang 
Published: September 2023

AbstractElectronic skins (E‐skins), which are intelligent extensions of the human skin, are in great demand because of the rapid development of information technology and intelligence in human civilization. Essentially, E‐skin systems are composed of functional and interface components. The function portion carries out various functions like sensing, power production, and therapy. In addition to ensuring consistent wear and comfort, the interface of the E‐skin system is necessary for the transfer of energy or mass between the skin and the functional components of the E‐skin system. The interface serves as the foundation, conduit, and link between the skin and functional components of E‐skin systems. The wearability and functionality of the E‐skin system are significantly impacted by the interfacial adhesion and the intermediate effect. It is crucial to build the interface in accordance with the functions of the E‐skin system. However, there are few reviews on the impact of the interface on the functionality and wearability of E‐skins. Here, the design of the E‐skin interface is thoroughly reviewed, taking into account how skin adhesion mechanisms affect wearability and function. At last, the future development direction and perspective of next‐generation E‐skin systems are presented.
Protocells Capable of Generating a Cytoskeleton‐Like Structure from Intracellular Membrane‐Active Artificial Organelles
Authors: Wang Dishi , Moreno Silvia , Gao Mengfei , Guo Jiaqi , Xu Bing , Voigt Dagmar , Voit Brigitte , Appelhans Dietmar 
Published: September 2023

AbstractThe intricate nature of eukaryotic cells with intracellular compartments having differences in component concentration and viscosity in their lumen provides (membrane‐active) enzymes to trigger time‐ and concentration‐dependent processes in the intra‐/extracellular matrix. Herein, membrane‐active, enzyme‐loaded artificial organelles (AOs) are capitalized upon to develop fluidic and stable proteinaceous membrane‐based protocells. AOs in protocells induce the self‐assembly of oligopeptides into an artificial cytoskeleton that underlines their influence on the structure and functionality of protocells. A series of microscopical tools is used to validate the intracellular assembly and distribution of cytoskeleton, the changing protocells morphology, and AOs inclusion within cytoskeletal growth. Thus, the dynamics, diffusion, and viscosity of intracellular components in the presence of cytoskeleton are evaluated by fluorescence tools and enzymatic assay. Membrane‐active alkaline phosphatase in polymersomes as AOs fulfills the requirements of biomimetic eukaryotic cells to trigger intracellular environment, mobility, viscosity, diffusion, and enzymatic activity itself as well as high mechanical stability and high membrane fluidity of protocells. Thus membrane‐active AOs in protocells provide a variable reaction space in a changing intracellular environment and underline their regulatory role in the fabrication of complex protocell architectures and functions. This study contributes significantly to the effective biomimetics of cell‐like structures, shapes, and functions.
Consistent Assessment of the Cooling Performance of Radiative Cooling Materials
Authors: Bu Kunlang , Huang Xingyi , Li Xiangyu , Bao Hua 
Published: September 2023

AbstractRadiative cooling has emerged as a passive cooling strategy and has attracted significant attention, particularly over the past five years. While many researchers have designed various radiative cooling materials and evaluated their cooling performance, inconsistent or even erroneous measurement data and different reporting styles widely exist. This lack of consistency adds complexity to the comparison and reproduction of cooling performance across the diverse range of radiative cooling materials studied by different researchers. In this paper, general considerations for assessing cooling performance measurements, including optical characterization and outdoor thermal measurements, are outlined. Moreover, guidelines on properly reporting measurement settings and results are provided. This work aims to help the radiative cooling community achieve consistent cooling performance assessment, ultimately advancing this promising technology toward alleviating global cooling demands.
Hierarchically Porous Iron Alloys with High Sintering Resistance During Cyclic Steam Oxidation and Hydrogen Reduction
Authors: Pennell Samuel M. , Chappuis Benoît , Carpenter Julia A. , Dunand David C. 
Published: September 2023

AbstractHydrogen release/storage materials for iron/air batteries are fabricated as Fe‐16Mo and Fe‐24Ni (at.%) lattices via 3D‐extrusion printing of foamed inks containing oxide microparticles, followed by H2 reduction and sintering. A hierarchical open porosity is designed: (i) channels between walls created during printing, (ii) mesopores within walls, created during ink foaming, and (iii) micropores within ligaments between mesopores, created from partial sintering metal particles and gas escape during cycling. When subjected to H2/H2O redox cycling at 800 °C, the lattices of both compositions gradually undergo sintering. The Fe‐16Mo lattice remains fully redox‐active after 50 cycles unlike the Fe‐24Ni lattice, which loses 90% of its redox capacity after 30 cycles. The increased lifetime of the Fe‐16Mo lattice is attributed to the sintering inhibition of Mo, the formation of a mixture of oxide phases in the oxidized state, and the cyclic formation of submicron Fe2Mo by reduction of MoO2 and Fe2Mo3O8. The microstructure of the foamed walls is examined throughout cycling to track changes in morphology and composition. These are correlated to volume and porosity changes in the lattice. A comparison is made to previously‐studied Fe‐Mo and Fe‐Ni freeze‐cast lamellar foams, and variations in performance are discussed in the context of the different architectures.
A 3D Framework with an In Situ Generated Li3N Solid Electrolyte Interphase for Superior Lithium Metal Batteries
Authors: Fu Xiangxiang , Duan Huanhuan , Zhang Leiting , Hu Yangming , Deng Yuanfu 
Published: September 2023

AbstractThe practical application of lithium (Li) metal for next‐generation rechargeable batteries is still hampered by uncontrolled growth of Li dendrite and severe volume change under repeated plating/stripping. Introducing a 3D structure to reserve space for Li storage and inducing uniform plating/stripping by a lithophilic interface layer are effective strategies to solve these problems. Herein, a novel 3D composite Li anode (Fe‐N@SSM‐Li) is constructed via an in situ reaction between Li and lithiophilic Fe2N/Fe3N (Fe‐N) uniformly anchored on a stainless‐steel mesh (SSM). The unique lithiophilic‐conductive structure of the Fe‐N@SSM‐Li can stabilize the Li anode by effectively inducing uniform and dense deposition and confining Li deposition inside the Fe‐N@SSM‐Li to alleviate volume changes. The Fe‐N@SSM‐Li displays a distinguished electrochemical performance, with superior lifespan of 5000, 2250, and 1350 h under 1 mA cm−2/1 mAh cm−2, 5 mA cm−2/3 mAh cm−2, and 20 mA cm−2/3 mAh cm−2 in symmetric cells, respectively. Combined with this highly stable Fe‐N@SSM‐Li, the full cells using LiFePO4 (LFP) and S/C cathodes both show significantly improved electrochemical performances. This work provides a low‐cost and scalable strategy for the construction of high‐efficiency Li anode with a novel 3D structure, offers new insights to the research of Li metal batteries and beyond.
Conducting Polymer Nanoparticles with Intrinsic Aqueous Dispersibility for Conductive Hydrogels
Authors: Tropp Joshua , Collins Caralyn P. , Xie Xinran , Daso Rachel E. , Mehta Abijeet Singh , Patel Shiv P. , Reddy Manideep M. , Levin Sophia E. , Sun Cheng , Rivnay Jonathan 
Published: September 2023

AbstractConductive hydrogels are promising materials with mixed ionic‐electronic conduction to interface living tissue (ionic signal transmission) with medical devices (electronic signal transmission). The hydrogel form factor also uniquely bridges the wet/soft biological environment with the dry/hard environment of electronics. The synthesis of hydrogels for bioelectronics requires scalable, biocompatible fillers with high electronic conductivity and compatibility with common aqueous hydrogel formulations/resins. Despite significant advances in the processing of carbon nanomaterials, fillers that satisfy all these requirements are lacking. Herein, intrinsically dispersible acid‐crystalized PEDOT:PSS nanoparticles (ncrys‐PEDOTX) are reported which are processed through a facile and scalable nonsolvent induced phase separation method from commercial PEDOT:PSS without complex instrumentation. The particles feature conductivities of up to 410 S cm−1, and when compared to other common conductive fillers, display remarkable dispersibility, enabling homogeneous incorporation at relatively high loadings within diverse aqueous biomaterial solutions without additives or surfactants. The aqueous dispersibility of the ncrys‐PEDOTX particles also allows simple incorporation into resins designed for microstereolithography without sonication or surfactant optimization; complex biomedical structures with fine features (< 150 µm) are printed with up to 10% particle loading . The ncrys‐PEDOTX particles overcome the challenges of traditional conductive fillers, providing a scalable, biocompatible, plug‐and‐play platform for soft organic bioelectronic materials.
Thermally Controllable Tuning of Emission Properties of Phenoxazine‐Substituted Acridones as One Step Forward to Efficient Organic Light‐Emitting Diodes Based on Crystalline Emitters
Authors: Guzauskas Matas , Volyniuk Dmytro , Kulszewicz‐Bajer Irena , Mahmoudi Malek , Lazauskas Algirdas , Jasinskas Vidmantas , Gulbinas Vidmantas , Pron Adam , Grazulevicius Juozas V. 
Published: September 2023

AbstractThe overwhelming majority of efficient organic light‐emitting diodes (OLEDs) are based on amorphous emitting layers. The devices with crystalline emitters usually show significantly worse performance. It is demonstrated that controlled thermal treatments of phenoxazine‐substituted acridones may lead to a spectacular improvement of photo‐ and electroluminescence of these luminophores. The three acridone derivatives studied, namely 2‐phenoxazine‐N‐hexylacridone (PHhA), 2,7‐bis‐(phenoxazine)‐N‐hexylacridone (bPHhA), and 2,7‐bis[3‐(phenoxazine)phenyl]‐N‐hexylacridone (PHPhhA), are characterized by relatively narrow photoluminescence spectra and photoluminescence quantum yields approaching 100%. These spectra can be reversibly tuned through appropriate thermal treatment of the deposited layers, undergoing shifts up to 92 nm upon transformation from amorphous to crystalline states. Strong thermally activated delayed fluorescence (TADF) observed for these compounds is manifested by a significantly higher reverse intersystem crossing rate of 1.92×106 s−1 as compared to the intersystem crossing rate of 5.68×105 s−1. These improvements are attributed to the annealing‐induced conformational equilibration due to crystallisation in combination with hosting. Adequacy of the proposed concept is demonstrated by the fabrication of devices exhibiting external quantum efficiencies reaching 20.7% – a record value for OLEDs with crystalline emitting layers. The presented approach of annealing‐induced conformational equilibration can lead to improved TADF properties for other fluorescent organic emitters presently considered inefficient.
Use of Deep‐Learning Assisted Assessment of Cardiac Parameters in Zebrafish to Discover Cyanidin Chloride as a Novel Keap1 Inhibitor Against Doxorubicin‐Induced Cardiotoxicity
Authors: Liu Changtong , Wang Yingchao , Zeng Yixin , Kang Zirong , Zhao Hong , Qi Kun , Wu Hongzhi , Zhao Lu , Wang Yi 
Published: September 2023

AbstractDoxorubicin‐induced cardiomyopathy (DIC) brings tough clinical challenges as well as continued demand in developing agents for adjuvant cardioprotective therapies. Here, a zebrafish phenotypic screening with deep‐learning assisted multiplex cardiac functional analysis using motion videos of larval hearts is established. Through training the model on a dataset of 2125 labeled ventricular images, ZVSegNet and HRNet exhibit superior performance over previous methods. As a result of high‐content phenotypic screening, cyanidin chloride (CyCl) is identified as a potent suppressor of DIC. CyCl effectively rescues cardiac cell death and improves heart function in both in vitro and in vivo models of Doxorubicin (Dox) exposure. CyCl shows strong inhibitory effects on lipid peroxidation and mitochondrial damage and prevents ferroptosis and apoptosis‐related cell death. Molecular docking and thermal shift assay further suggest a direct binding between CyCl and Keap1, which may compete for the Keap1‐Nrf2 interaction, promote nuclear accumulation of Nrf2, and subsequentially transactivate Gpx4 and other antioxidant factors. Site‐specific mutation of R415A in Keap1 significantly attenuates the protective effects of CyCl against Dox‐induced cardiotoxicity. Taken together, the capability of deep‐learning‐assisted phenotypic screening in identifying promising lead compounds against DIC is exhibited, and new perspectives into drug discovery in the era of artificial intelligence are provided.
Uncovering the role of FOXA2 in the Development of Human Serotonin Neurons
Authors: Xu Ting , Cao Lining , Duan Jinjin , Li Yingqi , Li You , Hu Zhangsen , Li Shuanqing , Zhang Meihui , Wang Guanhao , Guo Fei , Lu Jianfeng 
Published: September 2023

AbstractDirected differentiation of serotonin neurons (SNs) from human pluripotent stem cells (hPSCs) provides a valuable tool for uncovering the mechanism of human SN development and the associated neuropsychiatric disorders. Previous studies report that FOXA2 is expressed by serotonergic progenitors (SNPs) and functioned as a serotonergic fate determinant in mouse. However, in the routine differentiation experiments, it is accidentally found that less SNs and more non‐neuronal cells are obtained from SNP stage with higher percentage of FOXA2‐positive cells. This phenomenon prompted them to question the role of FOXA2 as an intrinsic fate determinant for human SN differentiation. Herein, by direct differentiation of engineered hPSCs into SNs, it is found that the SNs are not derived from FOXA2‐lineage cells; FOXA2‐knockout hPSCs can still differentiate into mature and functional SNs with typical serotonergic identity; FOXA2 overexpression suppresses the SN differentiation, indicating that FOXA2 is not intrinsically required for human SN differentiation. Furthermore, repressing FOXA2 expression by retinoic acid (RA) and dynamically modulating Sonic Hedgehog (SHH) signaling pathway promotes human SN differentiation. This study uncovers the role of FOXA2 in human SN development and improves the differentiation efficiency of hPSCs into SNs by repressing FOXA2 expression.
Advances and Regulation Strategies of the Active Moiety in Dual‐Atom Site Catalysts for Efficient Electrocatalysis
Authors: Zhu Peng , Xiong Xiang , Wang Dingsheng , Li Yadong 
Published: September 2023

AbstractDual‐atom site catalysts (DACs) have emerged as a new frontier in the heterogeneous catalysis field for electrochemical energy conversion systems. In this review, the superiority of DACs over single‐atom site catalysts is fully discussed. The origin of synergistic effects such as optimized d‐band structure, tailored spin state, and tuned charge transfer are pointed out. The merits in geometric and electronic structure render the active moiety versatile binding behavior toward adsorbed intermediate and beneficial synergistic effects to break the scaling relationships. The approaches to engineer the active moiety of DACs through modulating the central atoms, tuning the coordination environment, and engineering the metal‐support interaction are summarized. Finally, the current challenges and future research perspectives of DACs for efficient electrocatalysis are outlined.
Whole mount of adult ear skin as a model to study vascular malformations
Authors: Decker‐Rockefeller Brandee , Li Qingfen , Pumiglia Kevin 
Published: September 2023

AbstractBackgroundGenetic analysis in human patients has linked mutations in PIK3CA, the catalytic subunit of PI‐3′Kinase, to sporadic incidences of vascular malformations.MethodsWe have developed a mouse model with inducible and endothelial‐specific expression of PIK3CAH1047R, resulting in the development of vascular malformations. Systemic induction of this mutation in adult mice results in rapid lethality, limiting our ability to track and study these lesions; therefore, we developed a topical and local induction protocol using the active metabolite of tamoxifen, 4OH‐T, on the ear skin of adults.ResultsThis approach allows us to successfully model the human disease in a mature and established vascular bed and track the development of vascular malformations. To validate the utility of this model, we applied a topical rapamycin ointment, as rapamycin is therapeutically beneficial to patients in clinical trials. We found that the induced ear lesions showed significant attenuation after treatment, which was easily quantified.ConclusionsThese data collectively provide evidence of a new model to study vascular malformations in adult tissues, which should be particularly useful in environments lacking specialized small‐animal imaging facilities.
Activatable Type I Photosensitizer with Quenched Photosensitization Pre and Post Photodynamic Therapy
Authors: Tian Jianwu , Li Bowen , Zhang Fu , Yao Zhuo , Song Wentao , Tang Yufu , Ping Yuan , Liu Bin 
Published: September 2023

AbstractThe phototoxicity of photosensitizers (PSs) pre and post photodynamic therapy (PDT), and the hypoxic tumor microenvironment are two major problems limiting the application of PDT. While activatable PSs can successfully address the PS phototoxicity pre PDT, and type I PS can generate reactive oxygen species (ROS) effectively in hypoxic environment, very limited approaches are available for addressing the phototoxicity post PDT. There is virtually no solution available to address all these issues using a single design. Herein, we propose a proof‐of‐concept on‐demand switchable photosensitizer with quenched photosensitization pre and post PDT, which could be activated only in tumor hypoxic environment. Particularly, a hypoxia‐normoxia cycling responsive type I PS TPFN‐AzoCF3 was designed to demonstrate the concept, which was further formulated into TPFN‐AzoCF3 nanoparticles (NPs) using DSPE‐PEG‐2000 as the encapsulation matrix. The NPs could be activated only in hypoxic tumors to generate type I ROS during PDT treatment, but remain non‐toxic in normal tissues, pre or after PDT, thus minimizing side effects and improving the therapeutic effect. With promising results in in vitro and in vivo tumor treatment, this presented strategy will pave the way for the design of more on‐demand switchable photosensitizers with minimized side effects in the future.
Synthesis of Neocaesalpin A, AA, and Nominal Neocaesalpin K**
Authors: Papidocha Sven M. , Bulthaupt Hendrik H. , Carreira Erick M. 
Published: September 2023

AbstractThe first total synthesis of heavily oxidized cassane‐type diterpenoid neocaesalpin A (1) is disclosed. At the heart of the synthesis lies an intermolecular Diels–Alder reaction that rapidly assembles the target framework from commercial materials. A carefully orchestrated sequence of oxidations secured the desired oxygenation pattern. Late‐stage release of the characteristic butenolide occurred through a novel mercury(II)‐mediated furan oxidation. Successful extension of the route allowed preparation of neocaesalpin AA (2) as well as nominal neocaesalpin K (3) and suggested structural revision of neocaesalpin K, leading to the hypothesis that the two are likely the same natural product with correct assignment as 2.