bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reconciling continuous and discrete models of C4 and CAM evolution
Authors: Edwards Erika J 
Published: September 2023

Abstract

Background
A current argument in the CAM biology literature has focused on the nature of the CAM evolutionary trajectory: whether there is a smooth continuum of phenotypes between plants with C3 and CAM photosynthesis or whether there are discrete steps of phenotypic evolutionary change such as has been modelled for the evolution of C4 photosynthesis. A further implication is that a smooth continuum would increase the evolvability of CAM, whereas discrete changes would make the evolutionary transition from C3 to CAM more difficult.

Scope
In this essay, I attempt to reconcile these two viewpoints, because I think in many ways this is a false dichotomy that is constraining progress in understanding how both CAM and C4 evolved. In reality, the phenotypic space connecting C3 species and strong CAM/C4 species is both a continuum of variably expressed quantitative traits and yet also contains certain combinations of traits that we are able to identify as discrete, recognizable phenotypes. In this sense, the evolutionary mechanics of CAM origination are no different from those of C4 photosynthesis, nor from the evolution of any other complex trait assemblage.

Conclusions
To make progress, we must embrace the concept of discrete phenotypic phases of CAM evolution, because their delineation will force us to articulate what aspects of phenotypic variation we think are significant. There are some current phenotypic gaps that are limiting our ability to build a complete CAM evolutionary model: the first is how a rudimentary CAM biochemical cycle becomes established, and the second is how the ‘accessory’ CAM cycle in C3+CAM plants is recruited into a primary metabolism. The connections to the C3 phenotype we are looking for are potentially found in the behaviour of C3 plants when undergoing physiological stress – behaviour that, strangely enough, remains essentially unexplored in this context.
Artificial intelligence–based opportunistic detection of coronary artery stenosis on aortic computed tomography angiography in emergency department patients with acute chest pain
Authors: Glessgen Carl G , Boulougouri Marianthi , Vallée Jean-Paul , Noble Stéphane , Platon Alexandra , Poletti Pierre-Alexandre , Paul Jean-François , Deux Jean-François 
Published: September 2023

Abstract

Aims
To evaluate a deep-learning model (DLM) for detecting coronary stenoses in emergency room patients with acute chest pain (ACP) explored with electrocardiogram-gated aortic computed tomography angiography (CTA) to rule out aortic dissection.

Methods and results
This retrospective study included 217 emergency room patients (41% female, mean age 67.2 years) presenting with ACP and evaluated by aortic CTA at our institution. Computed tomography angiography was assessed by two readers, who rated the coronary arteries as 1 (no stenosis), 2 (&lt;50% stenosis), or 3 (≥50% stenosis). Computed tomography angiography was categorized as high quality (HQ), if all three main coronary arteries were analysable and low quality (LQ) otherwise. Curvilinear coronary images were rated by a DLM using the same system. Per-patient and per-vessel analyses were conducted. One hundred and twenty-one patients had HQ and 96 LQ CTA. Sensitivity, specificity, positive predictive value, negative predictive value (NPV), and accuracy of the DLM in patients with high-quality image for detecting ≥50% stenoses were 100, 62, 59, 100, and 75% at the patient level and 98, 79, 57, 99, and 84% at the vessel level, respectively. Sensitivity was lower (79%) for detecting ≥50% stenoses at the vessel level in patients with low-quality image. Diagnostic accuracy was 84% in both groups. All 12 patients with acute coronary syndrome (ACS) and stenoses by invasive coronary angiography (ICA) were rated 3 by the DLM.

Conclusion
A DLM demonstrated high NPV for significant coronary artery stenosis in patients with ACP. All patients with ACS and stenoses by ICA were identified by the DLM.
Mechanisms of benefits of sodium-glucose cotransporter 2 inhibitors in heart failure with preserved ejection fraction
Authors: Pandey Arjun K , Bhatt Deepak L , Pandey Avinash , Marx Nikolaus , Cosentino Francesco , Pandey Ambarish , Verma Subodh 
Published: September 2023

Abstract
For decades, heart failure with preserved ejection fraction (HFpEF) proved an elusive entity to treat. Sodium-glucose cotransporter 2 (SGLT2) inhibitors have recently been shown to reduce the composite of heart failure hospitalization or cardiovascular death in patients with HFpEF in the landmark DELIVER and EMPEROR-Preserved trials. While improvements in blood sugar, blood pressure, and attenuation of kidney disease progression all may play some role, preclinical and translational research have identified additional mechanisms of these agents. The SGLT2 inhibitors have intriguingly been shown to induce a nutrient-deprivation and hypoxic-like transcriptional paradigm, with increased ketosis, erythropoietin, and autophagic flux in addition to altering iron homeostasis, which may contribute to improved cardiac energetics and function. These agents also reduce epicardial adipose tissue and alter adipokine signalling, which may play a role in the reductions in inflammation and oxidative stress observed with SGLT2 inhibition. Emerging evidence also indicates that these drugs impact cardiomyocyte ionic homeostasis although whether this is through indirect mechanisms or via direct, off-target effects on other ion channels has yet to be clearly characterized. Finally, SGLT2 inhibitors have been shown to reduce myofilament stiffness as well as extracellular matrix remodelling/fibrosis in the heart, improving diastolic function. The SGLT2 inhibitors have established themselves as robust, disease-modifying therapies and as recent trial results are incorporated into clinical guidelines, will likely become foundational in the therapy of HFpEF.
Predicting pediatric healthcare provider use of virtual reality using a technology acceptance model
Authors: Wang Ellen Y , Kennedy Kristin M , Zhang Lijin , Qian Daniel , Forbes Ty , Zuniga-Hernandez Michelle , Li Brian S-K , Domingue Benjamin , Caruso Thomas J 
Published: September 2023

Abstract

Objective
The primary aim of this study was to apply a novel technology acceptance model (TAM) for virtual reality (VR) in healthcare. The secondary aim was to assess reliability of this model to evaluate factors that predict the intentions of pediatric health providers’ use of VR as an anxiolytic for hospitalized pediatric patients.

Materials and Methods
Healthcare providers that interacted with pediatric patients participated in a VR experience available as anxiolysis for minor procedures and then completed a survey evaluating attitudes, behaviors, and technology factors that influence adoption of new technologies.

Results
Reliability for all domain measurements were good, and all confirmatory factor analysis models demonstrated good fit. Usefulness, ease of use, curiosity, and enjoyment of the VR experience all strongly predict intention to use and purchase VR technologies. Age of providers, past use, and cost of technology did not influence future purchase or use, suggesting that VR technologies may be broadly adopted in the pediatric healthcare setting.

Discussion
Previous VR-TAM models in non-healthcare consumers formulated that age, past use, price willing to pay, and curiosity impacted perceived ease of use. This study established that age, past use, and cost may not influence use in healthcare. Future studies should be directed at evaluating the social influences and facilitating conditions within healthcare that play a larger influence on technology adoption.

Conclusion
The VR-TAM model demonstrated validity and reliability for predicting intent to use VR in a pediatric hospital.
Metastatic site patterns by intrinsic subtype and HER2DX in early HER2-positive breast cancer
Authors: Dieci Maria Vittoria , Conte PierFranco , Bisagni Giancarlo , Bartolini Stefania , Frassoldati Antonio , Generali Daniele , Piacentini Federico , Griguolo Gaia , Tagliafico Enrico , Brasó Maristany Fara , Chic Nuria , Paré Laia , Miglietta Federica , Vicini Roberto , D’Amico Roberto , Balduzzi Sara , Prat Aleix , Guarneri Valentina 
Published: September 2023

Abstract

Background
Even with contemporary treatment strategies, more than 10% of HER2-positive early stage breast cancer patients may experience distant metastasis as first event during follow-up. Tools for predicting unique patterns of metastatic spread are needed to plan personalized surveillance. We evaluated how molecular heterogeneity affects the pattern of distant relapse in HER2-positive breast cancer.

Methods
A total of 677 HER2-positive stage I-III breast cancer patients from ShortHER trial, Cher-LOB trial, and 2 institutional cohorts were included. PAM50 molecular subtypes and research-based HER2DX scores were evaluated. The cumulative incidence of distant relapse as the first event (any site and site specific) was evaluated using competing risk analysis. Median follow-up was 8.4 years. Tests of statistical significance are 2-sided.

Results
Stage III and high HER2DX risk score identified patients at the highest risk of distant relapse as first event (10-year incidence 24.5% and 19.7%, respectively). Intrinsic molecular subtypes were associated with specific patterns of metastatic spread: compared with other subtypes, HER2-enriched tumors were more prone to develop brain metastases (10-year incidence 3.8% vs 0.6%, P = .005), basal-like tumors were associated with an increased risk of lung metastases (10-year incidence 11.1% vs 2.6%, P = .001), and luminal tumors developed more frequently bone-only metastases (10-year incidence 5.1% vs 2.0%, P = .042). When added to stage or HER2DX risk score in competing risk regression models, intrinsic subtype maintained an independent association with site-specific metastases.

Conclusions
The integration of intrinsic molecular subtypes with stage or HER2DX risk score predicts site-specific metastatic risk in HER2-positive breast cancer, with potential implications for personalized surveillance and clinical trials aimed at preventing site-specific recurrence.
Association between a network-based physician linchpin score and cancer patient mortality: a SEER-Medicare analysis
Authors: Moen Erika L , Schmidt Rachel O , Onega Tracy , Brooks Gabriel A , O’Malley A James 
Published: September 2023

Abstract

Background
Patients with cancer frequently require multidisciplinary teams for optimal cancer outcomes. Network analysis can capture relationships among cancer specialists, and we developed a novel physician linchpin score to characterize “linchpin” physicians whose peers have fewer ties to other physicians of the same oncologic specialty. Our study examined whether being treated by a linchpin physician was associated with worse survival.

Methods
In this cross-sectional study, we analyzed Surveillance, Epidemiology, and End Results–Medicare data for patients diagnosed with stage I to III non-small cell lung cancer or colorectal cancer (CRC) in 2016-2017. We assembled patient-sharing networks and calculated linchpin scores for medical oncologists, radiation oncologists, and surgeons. Physicians were considered linchpins if their linchpin score was within the top 15% for their specialty. We used Cox proportional hazards models to examine associations between being treated by a linchpin physician and survival, with a 2-year follow-up period.

Results
The study cohort included 10 081 patients with non-small cell lung cancer and 9036 patients with CRC. Patients with lung cancer treated by a linchpin radiation oncologist had a 17% (95% confidence interval = 1.04 to 1.32) greater hazard of mortality, and similar trends were observed for linchpin medical oncologists. Patients with CRC treated by a linchpin surgeon had a 22% (95% confidence interval = 1.03 to 1.43) greater hazard of mortality.

Conclusions
In an analysis of Medicare beneficiaries with nonmetastatic lung cancer or CRC, those treated by linchpin physicians often experienced worse survival. Efforts to improve outcomes can use network analysis to identify areas with reduced access to multidisciplinary specialists.
Mobile colistin resistance (mcr) genes and recent developments in colistin resistance detection
Authors: Lakshmanan Divya , Ramasamy Dhamodharan , Subramanyam Veni , Saravanan Suresh Kumar 
Published: September 2023

Abstract
The peptide antibiotic colistin has been reserved as a last resort antibiotic treatment option for cases where other antibiotics including carbapenems have failed. Recent emergence of colistin resistance and discovery of mobile colistin resistance (mcr) genes, which encode the cell wall modifying phosphoethanolamine transferase enzyme, complicates the issue. The mcr genes have been associated with conjugative plasmids and can be horizontally transferred between different bacterial species. The global spread of mcr genes has been extensively documented and this warrants surveillance of the resistance genes in the community. However, susceptibility testing of colistin is fraught with practical challenges owing to the chemical nature of the drug and multiple mechanisms of resistance. Although broth microdilution is the current gold standard for colistin susceptibility testing, the method poses technical challenges. Hence, alternative detection methods for screening colistin resistance are the need of the hour. Several methods have been studied in the recent times to address this issue. In this review, we discuss some of the recent developments in the detection of colistin resistance.
The elemental abundance of quiescent galaxies in the LEGA-C survey: the (non-)evolution of [α/Fe] from z = 0.75 to z = 0
Authors: Bevacqua Davide , Saracco Paolo , La Barbera Francesco , D’Ago Giuseppe , De Propris Roberto , Ferreras Ignacio , Gallazzi Anna , Pasquali Anna , Spiniello Chiara 
Published: September 2023

ABSTRACT
We measure the [α/Fe] abundances for 183 quiescent galaxies at z = 0.60−0.75 with stellar masses ranging 10.4 ≤ log10(M*/M⊙) ≤ 11.6 selected from the Large Early Galaxy Astrophysics Census survey. We estimate [α/Fe] from the ratio of the spectral indices Mgb (λ ∼ 5177 Å) and Fe4383, compared to predictions of simple stellar population models. We find that 91 per cent of quiescents in our sample have supersolar [α/Fe], with an average value of [α/Fe] = +0.24 ± 0.01. We find no significant correlation between [α/Fe] and stellar metallicity, mass, velocity dispersion, and average formation time. Galaxies that formed the bulk of their stellar mass on time-scales shorter than 1 Gyr follow the same [α/Fe] distribution as those which formed on longer time-scales. In comparison to local early-type galaxies and to stacked spectra of quiescent galaxies at z = 0.38 and z = 0.07, we find that the average [α/Fe] has not changed between z = 0.75 and the present time. Our work shows that the vast majority of massive quiescent galaxies at z ∼ 0.7 are α-enhanced, and that no detectable evolution of the average [α/Fe] has taken place over the last ∼6.5 Gyr.
ALMA observations of the Extended Green Object G19.01–0.03 – ii. A massive protostar with typical chemical abundances surrounded by four low-mass pre-stellar core candidates
Authors: Williams G M , Cyganowski C J , Brogan C L , Hunter T R , Nazari P , Smith R J 
Published: September 2023

ABSTRACT
We present a study of the physical and chemical properties of the Extended Green Object (EGO) G19.01−0.03 using sub-arcsecond angular resolution Atacama Large Millimetre/submillimetre Array (ALMA) 1.05 mm and Karl G. Jansky Very Large Array (VLA) 1.21 cm data. G19.01−0.03 MM1, the millimetre source associated with the central massive young stellar object (MYSO), appeared isolated and potentially chemically young in previous Submillimetre Array observations. In our ∼0.4 arcsec-resolution ALMA data, MM1 has four low-mass millimetre companions within 0.12 pc, all lacking maser or outflow emission, indicating they may be pre-stellar cores. With a rich ALMA spectrum full of complex organic molecules, MM1 does not appear chemically young, but has molecular abundances typical of high-mass hot cores in the literature. At the 1.05 mm continuum peak of MM1, N(CH3OH) = (2.22 ± 0.01) × 1018 cm−2 and $T_{\mathrm{ex}} = 162.7\substack{+0.3 \\ -0.5}$ K based on pixel-by-pixel Bayesian analysis of LTE synthetic methanol spectra across MM1. Intriguingly, the peak CH3OH Tex = 165.5 ± 0.6 K is offset from MM1’s millimetre continuum peak by 0.22 arcsec ∼ 880 au, and a region of elevated CH3OH Tex coincides with free–free VLA 5.01 cm continuum, adding to the tentative evidence for a possible unresolved high-mass binary in MM1. In our VLA 1.21 cm data, we report the first NH3(3,3) maser detections towards G19.01−0.03, along with candidate 25 GHz CH3OH 5(2, 3) − 5(1, 4) maser emission; both are spatially and kinematically coincident with 44 GHz Class I CH3OH masers in the MM1 outflow. We also report the ALMA detection of candidate 278.3 GHz Class I CH3OH maser emission towards this outflow, strengthening the connection of these three maser types to MYSO outflows.
Resolving the physics of quasar Ly α nebulae (RePhyNe): I. Constraining quasar host halo masses through circumgalactic medium kinematics
Authors: de Beer S , Cantalupo S , Travascio A , Pezzulli G , Galbiati M , Fossati M , Fumagalli M , Lazeyras T , Pensabene A , Theuns T , Wang W 
Published: September 2023

ABSTRACT
Ly α nebulae ubiquitously found around z &gt; 2 quasars can supply unique constraints on the properties of the circumgalactic medium, such as its density distribution, provided the quasar halo mass is known. We present a new method to constrain quasar halo masses based on the line-of-sight velocity dispersion maps of Ly α nebulae. By using MUSE-like mock observations obtained from cosmological hydrodynamic simulations under the assumption of maximal quasar fluorescence, we show that the velocity dispersion radial profiles of Ly α emitting gas are strongly determined by gravity and that they are thus self-similar with respect to halo mass when rescaled by the virial radius. Through simple analytical arguments and by exploiting the kinematics of He ii1640 Å emission for a set of observed nebulae, we show that Ly α radiative transfer effects plausibly do not change the shape of the velocity dispersion profiles but only their normalization without breaking their self-similarity. Taking advantage of these results, we define the variable $\eta ^{140-200}_{40-100}$ as the ratio of the median velocity dispersion in two specifically selected annuli and derive an analytical relation between $\eta ^{140-200}_{40-100}$ and the halo mass which can be directly applied to observations. We apply our method to 37 observed quasar Ly α nebulae at 3 &lt; z &lt; 4.7 and find that their associated quasars are typically hosted by ∼1012.16 ± 0.14M⊙ haloes independent of redshift within the explored range. This measurement, which is completely independent of clustering methods, is consistent with the lowest mass estimates based on quasar autocorrelation clustering at z∼3 and with quasar-galaxies cross-correlation results.
Exploring the evolution of dust temperature using spectral energy distribution fitting in a large photometric survey
Authors: Jones Gareth T , Stanway Elizabeth R 
Published: September 2023

ABSTRACT
Panchromatic analysis of galaxy spectral energy distributions, spanning from the ultraviolet to the far-infrared, probes not only the stellar population but also the properties of interstellar dust through its extinction and long-wavelength re-emission. However, little work has exploited the full power of such fitting to constrain the redshift evolution of dust temperature in galaxies. To do so, we simultaneously fit ultraviolet, optical, and infrared observations of stacked galaxy subsamples at a range of stellar masses and photometric redshifts at 0 &lt; z &lt; 5, using an energy-balance formalism. However, we find UV-emission beyond the Lyman limit in some photometric redshift selected galaxy subsamples, giving rise to the possibility of contaminated observations. We carefully define a robust clean subsample which extends to no further than z ∼ 2. This has consistently lower derived temperatures by $4.0^{+5.0}_{-1.9}$ K, relative to the full sample. We find a linear increase in dust temperature with redshift, with Td (z) = (4.8 ± 1.5) × z + (26.2 ± 1.5) K. Our inferred temperature evolution is consistent with a modest rise in dust temperature with redshift, but inconsistent with some previous analyses. We also find a majority of photometrically selected subsamples at z &gt; 4.5 underpredict the IR emission while giving reasonable fits to the UV-optical. This could be due to a spatial disconnect in the locations of the UV and IR emission peaks, suggesting that an energy-balance formalism may not always be applicable in the distant Universe.
Ultraluminous quasars at high redshift show evolution in their radio-loudness fraction in both redshift and ultraviolet luminosity
Authors: Lah Philip , Onken Christopher A , Norris Ray P , D’Eugenio Francesco 
Published: September 2023

ABSTRACT
We take a sample of 94 ultraluminous, optical quasars from the search of over 14 486 deg2 by Onken et al. in the range 4.4 &lt; redshift &lt; 5.2 and match them against the Rapid ASKAP Continuum Survey (RACS) observed on the Australian Square Kilometre Array Pathfinder (ASKAP). From this most complete sample of the bright end of the redshift ∼5 quasar luminosity function, there are 10 radio continuum detections, of which eight are considered radio-loud quasars. The radio-loud fraction for this sample is 8.5 ± 2.9 per cent. Jiang et al. found that there is a decrease in the radio-loud fraction of quasars with increasing redshift and an increase with increasing absolute magnitude at rest frame 2500 Å. We show that the radio-loud fraction of our quasar sample is consistent with that predicted by Jiang et al.,extending their result to higher redshifts.
Buoyancy response of a disc to an embedded planet: a cross-code comparison at high resolution
Authors: Ziampras Alexandros , Paardekooper Sijme-Jan , Nelson Richard P 
Published: September 2023

ABSTRACT
In radiatively inefficient, laminar protoplanetary discs, embedded planets can excite a buoyancy response as gas gets deflected vertically near the planet. This results in vertical oscillations that drive a vortensity growth in the planet’s corotating region, speeding up inward migration in the type-I regime. We present a comparison between pluto/idefix and fargo3D using 3D, inviscid, adiabatic numerical simulations of planet–disc interaction that feature the buoyancy response of the disc, and show that pluto/idefix struggle to resolve higher-order modes of the buoyancy-related oscillations, weakening vortensity growth, and the associated torque. We interpret this as a drawback of total-energy-conserving finite-volume schemes. Our results indicate that a very high resolution or high-order scheme is required in shock-capturing codes in order to adequately capture this effect.
Complexity of Infectious Diseases Compared With Other Medical Subspecialties
Authors: Grundy Brian , Houpt Eric 
Published: September 2023

Abstract
We aimed to highlight the complexity of the field of clinical infectious diseases compared with other medical specialties. Using available metrics, the body of knowledge within clinical infectious diseases is comparatively large and complex. This increasing complexity is underappreciated by current physician compensation schemes, needs to be carefully managed to educate future physicians, and may serve as a barrier to recruitment into the field.