bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mujeres con “La Soja al Cuello”. Experiencias y Evidencias en Torno a la Contaminación de Cuerpos y Territorios en Buenos Aires
Authors: Gárgano Cecilia 
Published: December 2022

El uso intensivo de plaguicidas en la actividad agrícola ha configurado múltiples efectos socioambientales entre los que se destacan la contaminación de aguas y la aparición de diversas patologías en la población. Este artículo aborda un estudio de caso radicado en el partido de Pergamino, provincia de Buenos Aires, Argentina. Mediante el análisis de prensa gráfica, documentos de investigación, informes de peritos, la totalidad de una causa judicial, así como de entrevistas realizadas a residentes, investigadores y querellantes, se analizan dos ejes. Por un lado, se reconstruyen experiencias de vida de mujeres afectadas. Por otro lado, se problematiza el lugar que ocupan en esta problemática estas experiencias y las evidencias que son instadas a presentar para probar los daños asociados. Las conclusiones señalan que el proceso de construcción de la evidencia científica opera en forma divergente cuando involucra ámbitos oficiales y cuando es demandada a población afectada. La depredación de los cuerpos y las aguas es posibilitada por diversos mecanismos institucionales, jurídicos, discursivos y materiales que fragmentan situaciones comunes y construyen a los efectos ambientales y sanitarios en episodios aislados. De este modo, la inversión de la carga de prueba se presenta como una de las condiciones necesarias para la expansión de estas prácticas productivas.
Fuerzas Armadas en orden interno: Normalización de la excepcionalidad chilena
Authors: Álvarez Gonzalo , Gómez Giovana 
Published: December 2022

Abstract: Armed forces in internal order. Normalisation of Chilean exceptionalityIn Latin America, it has been argued that the involvement of the armed forces in tasks of internal order is mainly a consequence of the overflow of public security. In the case of Chile, although this trend was not observed, there is a growing participation of the military in internal missions. This article argues that this is due to civil neglect of defence matters, where the institutionalization of the roles and missions of the armed forces towards non-traditional functions has been promoted without consolidating the development of new capabilities and regulations on their operations. This has lead to civil irresponsibility, in which the authorities are promoting the deliberate use of the military in internal affairs through specific policies and through the normalization of states of constitutional exception, which generates problems both for the military institutions as for its democratic control. ResumenEn América Latina se ha planteado que el involucramiento de las fuerzas armadas en tareas de orden interno es principalmente consecuencia del desborde de la seguridad pública. En el caso de Chile, si bien no se observaba esta tendencia, se advierte una participación creciente de los militares en misiones internas. En este artículo se sostiene que esto obedece a un descuido civil por los asuntos de defensa, donde se ha impulsado la institucionalización de los roles y misiones de las fuerzas armadas hacia funciones no tradicionales sin consolidar el desarrollo de nuevas capacidades y normativas sobre sus operaciones. Esto ha abierto la puerta a una irresponsabilidad civil, en que las autoridades están promoviendo el uso deliberado de los militares en asuntos internos a través de políticas específicas y mediante la normalización de estados de excepción constitucional, lo cual genera problemas tanto para las instituciones militares como para su control democrático.
Ciudadanía, ¿por qué no? Prácticas políticas de juventudes afrocolombianas en Quibdó
Authors: Howald Claudia 
Published: December 2022

El texto explora qué puede significar ciudadanía para las juventudes afrocolombianas en Quibdó, en el Pacífico colombiano. Un entorno urbano marcado por exclusiones y violencias protagonizadas por jóvenes, pero también por un sinnúmero de iniciativas sociales, culturales y deportivas impulsadas por jóvenes. La creatividad y la dimensión política de estas iniciativas juveniles estimulan mi reflexión: ¿Estas formas de agencia política juvenil pueden ser analizadas como prácticas de ciudadanía? Una mirada atenta me lleva a cuestionar la misma categoría ciudadanía: ¿Porque analizar las prácticas políticas de las juventudes en Quibdó a partir de un concepto que no es movilizado localmente? ¿Cuáles son los límites del concepto de ciudadanía para las organizaciones juveniles en el Pacífico? En fin, ¿porqué ciudadanía no?
Project publication: Two-year follow-up of infant and maternal outcomes after planned early delivery or expectant management for late preterm pre-eclampsia (PHOENIX): a randomised controlled trial
Authors: Chappell Lucy C , Brocklehurst Peter , Green Marcus , Hardy Pollyanna , Hunter Rachael , Beardmore-Gray Alice , Bowler Ursula , Brockbank Anna , Chiocchia Virginia , Cox Alice , Duhig Kate , Fleminger Jessica , Gill Carolyn , Greenland Melanie , Hendy Eleanor , Kennedy Ann , Leeson Paul , Linsell Louise , McCarthy Fergus P , O’Driscoll Jamie , Placzek Anna , Poston Lucilla , Robson Stephen , Rushby Pauline , Sandall Jane , Scholtz Laura , Seed Paul T , Sparkes Jenie , Stanbury Kayleigh , Tohill Sue , Thilaganathan Basky , Townend John , Juszczak Edmund , Marlow Neil , Shennan Andrew 
Published: December 2022

Objective
We evaluated the best time to initiate delivery in late preterm pre-eclampsia in order to optimise long-term infant and maternal outcomes.

Design
Parallel-group, non-masked, randomised controlled trial.

Setting
46 UK maternity units.

Population
Women with pre-eclampsia between 34+0 and 36+6 weeks’ gestation, without severe disease, were randomised to planned delivery or expectant management.

Primary long-term outcome
Infant neurodevelopmental outcome at 2 years of age, using the PARCA-R (Parent Report of Children’s Abilities-Revised) composite score.

Results
Between 29 September 2014 and 10 December 2018, 901 women were enrolled in the trial, with 450 allocated to planned delivery and 451 to expectant management. At 2-year follow-up, the intention-to-treat analysis population included 276 women (290 infants) allocated to planned delivery and 251 women (256 infants) to expectant management. The mean composite standardised PARCA-R scores were 89.5 [standard deviation (SD) 18.2] in the planned delivery group and 91.9 (SD 18.4) in the expectant management group, with an adjusted mean difference of −2.4 (95% CI −5.4 to 0.5) points.

Conclusion
In infants of women with late preterm pre-eclampsia, average neurodevelopmental assessment at 2 years lies within the normal range, regardless of whether planned delivery or expectant management is pursued. Because of lower than anticipated follow-up, there was limited power to demonstrate these scores were not different, but the small between-group difference in PARCA-R scores is unlikely to be clinically important.
Cost-utility analysis of planned early delivery or expectant management for late preterm pre-eclampsia (PHOENIX)
Authors: Chappell Lucy C , Brocklehurst Peter , Green Marcus , Hardy Pollyanna , Hunter Rachael , Beardmore-Gray Alice , Bowler Ursula , Brockbank Anna , Chiocchia Virginia , Cox Alice , Duhig Kate , Fleminger Jessica , Gill Carolyn , Greenland Melanie , Hendy Eleanor , Kennedy Ann , Leeson Paul , Linsell Louise , McCarthy Fergus P , O’Driscoll Jamie , Placzek Anna , Poston Lucilla , Robson Stephen , Rushby Pauline , Sandall Jane , Scholtz Laura , Seed Paul T , Sparkes Jenie , Stanbury Kayleigh , Tohill Sue , Thilaganathan Basky , Townend John , Juszczak Edmund , Marlow Neil , Shennan Andrew 
Published: December 2022

Aim
There is currently limited evidence on the costs associated with late preterm pre-eclampsia beyond antenatal care and post-natal discharge from hospital. The aim of this analysis is to evaluate the 24-month cost-utility of planned delivery for women with late preterm pre-eclampsia at 34+0 and 36+6 weeks’ gestation compared to expectant management from an English National Health Service perspective using participant-level data from the PHOENIX trial.

Methods
Women between 34+0 and 36+6 weeks' gestation in 46 maternity units in England and Wales were individually randomised to planned delivery or expectant management. Resource use was collected from hospital records between randomisation and primary hospital discharge following birth. Women were followed up at 6 months and 24 months following birth and self-reported resource use for themselves and their infant(s) covering the previous 6 months. Women completed the EQ-5D-5L at randomisation and follow-up.

Results
A total of 450 women were randomised to planned delivery, 451 to expectant management: 187 and 170 women, respectively, had complete data at 24 months. Planned delivery resulted in a significantly lower mean cost per woman and infant(s) over 24 months [−£2711, 95% confidence interval (CI) −4840 to −637], with a mean incremental difference in QALYs of 0.019 (95% CI −0.039 to 0.063). Short-term and 24-month infant costs were not significantly different between the intervention arms. There is a 99% probability that planned delivery is cost-effective at all thresholds below £37,000 per QALY gained.

Conclusion
There is a high probability that planned delivery is cost-effective compared to expectant management. These results need to be considered alongside clinical outcomes and in the wider context of maternity care.

Trial registration
ISRCTN registry ISRCTN01879376. Registered 25 November 2013.
Pemanfaatan Website Desa Dalam Optimalisasi Informasi Publik kepada masyarakat di Desa Kiringan
Authors: Pamungkas Ridho , Saifullah Saifullah , Pratama Qoirrudin Raga , Try Cahyo Okky Aldhy 
Published: December 2022

Abstractâ€” Information and communication technology is currently developing very rapidly, this is indicated by the use of the internet by the general public. The internet as a medium of communication and information has now become a primary need. The benefits of the internet are very large, especially in the world of education, entertainment, business and government. Kiringan village is one of the villages located in Takeran District, Magetan Regency. Kiringan Village still uses conventional information media, namely by using a notice board located at the village office to convey public information such as an introduction to the organizational structure, activities, location and village potentials that the community feels is less legible. With the development of information and communication technology that is increasingly rapid and massive, the village of Kiringan needs an online information medium which can also be called a village website. So that this village website is expected to optimize public information to the Kiringan village community and the community outside the Kiringan village as a village promotion media in introducing the village potentials as well as the administration of public services in the Kiringan village.Â Keywordsâ€”: Information Technology; Kiringan Village; Public service; Village Website.
RH5.1-CyRPA-Ripr antigen combination vaccine shows little improvement over RH5.1 in a preclinical setting
Authors: Healer Julie , Thompson Jennifer K. , Mackwell Karen L. , Browne Cecille D. , Seager Benjamin A. , Ngo Anna , Lowes Kym N. , Silk Sarah E. , Pulido David , King Lloyd D. W. , Christen Jayne M. , Noe Amy R. , Kotraiah Vinayaka , Masendycz Paul J. , Rajagopalan Rajkannan , Lucas Leanne , Stanford Marianne M. , Soisson Lorraine , Diggs Carter , Miller Robin , Youll Susan , Wycherley Kaye , Draper Simon J. , Cowman Alan F. 
Published: December 2022

BackgroundRH5 is the leading vaccine candidate for the Plasmodium falciparum blood stage and has shown impact on parasite growth in the blood in a human clinical trial. RH5 binds to Ripr and CyRPA at the apical end of the invasive merozoite form, and this complex, designated RCR, is essential for entry into human erythrocytes. RH5 has advanced to human clinical trials, and the impact on parasite growth in the blood was encouraging but modest. This study assessed the potential of a protein-in-adjuvant blood stage malaria vaccine based on a combination of RH5, Ripr and CyRPA to provide improved neutralizing activity against P. falciparum in vitro.MethodsMice were immunized with the individual RCR antigens to down select the best performing adjuvant formulation and rats were immunized with the individual RCR antigens to select the correct antigen dose. A second cohort of rats were immunized with single, double and triple antigen combinations to assess immunogenicity and parasite neutralizing activity in growth inhibition assays.ResultsThe DPX® platform was identified as the best performing formulation in potentiating P. falciparum inhibitory antibody responses to these antigens. The three antigens derived from RH5, Ripr and CyRPA proteins formulated with DPX induced highly inhibitory parasite neutralising antibodies. Notably, RH5 either as a single antigen or in combination with Ripr and/or CyRPA, induced inhibitory antibodies that outperformed CyRPA, Ripr.ConclusionAn RCR combination vaccine may not induce substantially improved protective immunity as compared with RH5 as a single immunogen in a clinical setting and leaves the development pathway open for other antigens to be combined with RH5 as a next generation malaria vaccine.
Edgeworthia gardneri (Wall.) Meisn. extract protects against myocardial infarction by inhibiting NF-κB-and MAPK-mediated endothelial inflammation
Authors: Wei Dan , Tang Le , Su Lingqing , Zeng Sufen , Telushi Ajdora , Lang Xiaoya , Zhang Yanli , Qin Manman , Qiu Liang , Zhong Chao , Yu Jun 
Published: December 2022

BackgroundExperimental and clinical evidence has demonstrated a pivotal role of inflammation in the pathogenesis of ischemic heart disease, and targeting inflammation has been shown to provide clinical benefits for patients with coronary disease. Endothelial cells constitute the majority of non-cardiomyocytes in the heart. Endothelial pro-inflammatory activation is recognized as a critical component in the pathophysiology of cardiovascular disease. The dried flowers of Edgeworthia gardneri (Wall.) Meisn. (EG) have been widely used as Tibetan folk medicine to ameliorate a range of metabolic disorders, such as diabetes mellitus, hyperlipidemia, hypertension, and obesity. However, its role in modulating endothelial inflammation and ischemic heart disease has not been evaluated.Methods and resultsHerein, using a preclinical rat model of coronary artery ligation-induced myocardial infarction (MI), we demonstrated that systemic administration of EG extract (EEEG) attenuated ischemic cardiac injury. EEEG reduced myocardial infarct size, improved cardiac function, and ameliorated adverse cardiac remodeling. Moreover, the cardioprotective effects of EEEG were associated with decreased MI-induced myocardial inflammation. Consistent with the anti-inflammatory role of EEEG in vivo, EEEG attenuated TNF-α-stimulated human umbilical vein endothelial cells (HUVECs) activation and monocyte-endothelial cell firm adhesion in vitro. Mechanistically, our data showed that EEEG’s mode of action suppresses the activation of NF-κB, ERK, and p38 MAPK signaling pathways in ECs. Importantly, we demonstrated that EEEG inhibits endothelial inflammation in an NF-κB- and p38 MAPK-dependent manner using pharmacological inhibitors.ConclusionCollectively, this study identified EG as a potential therapeutic agent in attenuating endothelial inflammation and managing ischemic cardiovascular disease.
Markers of extracellular matrix remodeling and systemic inflammation in patients with heritable thoracic aortic diseases
Authors: Seim Bjørn Edvard , Holt Margrethe Flesvig , Ratajska Aleksandra , Michelsen Annika , Ringseth Monica Myklebust , Halvorsen Bente Evy , Skjelland Mona , Kvitting John-Peder Escobar , Lundblad Runar , Krohg-Sørensen Kirsten , Osnes Liv T. N. , Aukrust Pål , Paus Benedicte , Ueland Thor 
Published: December 2022

BackgroundIn approximately 20% of patients with thoracic aortic aneurysms or dissections a heritable thoracic aortic disease (HTAD) is suspected. Several monogenic connective tissue diseases imply high risk of aortic disease, including both non-syndromic and syndromic forms. There are some studies assessing inflammation and extracellular matrix remodeling in patients with non-hereditary aortic disease, but such studies in patients with hereditary diseases are scarce.AimsTo quantify markers of extracellular matrix (ECM) and inflammation in patients with vascular connective tissue diseases versus healthy controls.MethodsPatients with Loeys-Dietz syndrome (LDS, n = 12), Marfan syndrome (MFS, n = 11), and familial thoracic aortic aneurysm 6 (FTAA6, n = 9), i.e., actin alpha 2 (ACTA2) pathogenic variants, were recruited. Exome or genome sequencing was performed for genetic diagnosis. Several markers of inflammation and ECM remodeling were measured in plasma by enzyme immunoassays. Flow cytometry of T-cell subpopulations was performed on a subgroup of patients. For comparison, blood samples were drawn from 14 healthy controls.Results(i) All groups of HTAD patients had increased levels matrix metalloproteinase-9 (MMP-9) as compared with healthy controls, also in adjusted analyses, reflecting altered ECM remodeling. (ii) LDS patients had increased levels of pentraxin 3 (PTX3), reflecting systemic inflammation. (iii) LDS patients have increased levels of soluble CD25, a marker of T-cell activation.ConclusionOur data suggest that upregulated MMP-9, a matrix degrading enzyme, is a common feature of several subgroups of HTAD. In addition, LDS patients have increased levels of PTX3 reflecting systemic and in particular vascular inflammation.
Prognostic implication of left ventricular hypertrophy regression after antihypertensive therapy in patients with hypertension
Authors: Kim Hyue Mee , Hwang In-Chang , Choi Hong-Mi , Yoon Yeonyee Elizabeth , Cho Goo-Yeong 
Published: December 2022

BackgroundLeft ventricular (LV) hypertrophy (LVH) in patients with hypertension is a significant risk factor for cardiovascular mortality and morbidity. However, the prognostic implication of LVH regression after antihypertensive therapy has not been clearly investigated.MethodsPatients who underwent echocardiography at the time of the diagnosis of hypertension and repeated echocardiography at an interval of 6–18 months were retrospectively identified. LVH was defined as LV mass index (LVMI) &gt;115 g/m2 (men) and &gt;95 g/m2 (women). LVH regression was defined as LVH at initial echocardiography with normal geometry or concentric LV remodeling at follow-up echocardiography. Cardiovascular mortality, hospitalization for heart failure (HHF), coronary revascularization, stroke, and aortic events were analyzed according to changes in LVMI and geometry.ResultsOf 1,872 patients, 44.7% (n = 837) had LVH at the time of diagnosis; among these, 30.7% showed LVH regression. The reduction in LVMI was associated with the reduction in BP, especially in those with LVH at baseline. During follow up (median, 50.4 months; interquartile range, 24.9–103.2 months), 68 patients died of cardiovascular causes, 127 had HHF, and 162 had vascular events (coronary revascularization, stroke, and aortic events). Persistent or newly developed LVH during antihypertensive therapy was a significant predictor of cardiovascular mortality and events, especially HHF. On multivariable analysis, women, diabetes, atrial fibrillation, coronary artery disease, larger LVMI and end-diastolic dimension, and less reduction in systolic BP were associated with persistent or newly developed LVH.ConclusionLVH regression in patients with hypertension is associated with a reduction in cardiovascular events and can be used as a prognostic marker.
Pathways of carbonate sediment accumulation in a large, shallow lake
Authors: Rostási Ágnes , Rácz Kornél , Fodor Melinda A. , Topa Boglárka , Molnár Zsombor , Weiszburg Tamás G. , Pósfai Mihály 
Published: December 2022

Since carbonate formation is an important process linking inorganic and biological components of freshwater ecosystems, we characterized the formation of modern carbonate sediments in a large, shallow, calcareous lake (Lake Balaton in Hungary). We measured the amount of allochtonous mineral particles delivered to the lake by tributaries and through the atmosphere over a 2-year period, and estimated the mass of carbonate minerals that precipitated from lakewater. Chemical and structural features of mineral particles from various sources were also studied. Both the mineralogical character and the amount of particles delivered by streams and through the atmosphere were similar, and formed a minor fraction of the annual sediment increment (∼5%–6% by mass). Since the watercourses feeding the lake had high concentrations of Ca2+, Mg2+, and HCO3− (with a Mg/Ca mol ratio ranging from 1 to 4), Mg-bearing calcite (with 2–17 mol% MgCO3) was found to continually precipitate in the lake. According to X-ray powder diffraction measurements, the Mg content of calcite increased from West to East, in parallel with changes in water chemistry. Dolomite was detected as a minor phase, and in the eastern part of the lake it typically produced a split 104 peak in X-ray diffractograms, suggesting two distinct sources: stoichiometric dolomite was allochtonous, whereas a Ca-rich protodolomite fraction formed in the lake. Mg-bearing calcite precipitating in the lake was found by far the largest contributor to sediment formation, with an estimated annual accumulation of about 0.75–0.9 mm consolidated sediment; thus, ∼89% of the currently forming sediment consists of autochtonous carbonate. In addition to providing new estimates for the rates of accumulation of distinct sediment fractions, our results also provide a baseline for further studies on the retention and release of nutrients by sediment minerals.
Retrospective analysis: The application of human menopausal gonadotropin combined with letrozole for IUI in patients undergoing artificial insemination by husband due to unexplained or mild male factors
Authors: Li Hua-qing , Pan Xin-ling , Su Nian-jun , Lu Xi-ping , Chen Jun-qing , Chen Xu-wei 
Published: December 2022

ObjectiveTo compare the effects of human menopausal gonadotropin (HMG) combined with letrozole (LE) to HMG only for ovarian stimulation on pregnancy outcome of infertile patients undergoing artificial insemination by husband (AIH) due to unexplained or mild male factors.Materials and methodsInfertile patients with unexplained or mild male factors treated from July 2015 to December 2021 were selected as subjects. The patients were divided into two groups according to the ovarian stimulation schemes they received, namely HMG combined with LE or HMG only. We analyzed the laboratory examination results before drug treatment (baseline) and during ovarian stimulation and compared the pregnancy outcomes of the two groups using univariable analysis and multivariable logistic regression analysis.ResultsIn total, 526 cycles of 372 couples were included. The univariate analysis showed that the clinical pregnancy rate of the HMG combined with LE group was 24.8%, significantly higher than that of the HMG group (14.8%, P = 0.007). The live birth rate (19.9%) of the HMG combined with LE group were also significantly higher than those of the HMG group (11.2%, respectively). In multivariate logistic analysis, the age of males was negatively associated with the clinical pregnancy rate (OR 0.874, 95% CI 0.793~0.963, P=0.006) and live birth (OR0.875, 95% CI 0.783~0.977, P=0.018). Moreover, ovarian stimulation with HMG+LE was the only beneficial factor significantly associated with clinical pregnancy (OR 1.929, 95% CI 1.068~3.485, P=0.029) and live birth (OR 2.255, 95% CI 1.188~4.282, P=0.013).ConclusionOvarian stimulation using HMG combined with LE can increase the clinical outcomes (live birth and clinical pregnancy) among infertile patients undergoing AIH due to explained or mild male factors.