bluuebunny/crossref_metadata_2025_split huggingface dataset:
The ever wider clinical spectrum of RMND1-related disorders and limitedness of phenotype-based classifications
Authors: Rioux Alexis V. , Riopel Julie , Marcoux Nicolas , Thériault Catherine , Gould Peter V. , Garneau Alexandre P. , Isenring Paul 
Published: April 2023

Abstract
RMND1 has been identified as a mitochondriopathy-associated gene less than 12 years ago. The most common phenotype related to this gene is an early onset, severe form of encephalomyopathy that leads to death in a medium time of three years after birth. However, milder and later onset presentations have been reported in some individuals, including two in whom the mitochondriopathy was identified at ~ 40 years of age, and the early onset presentations have been the object of no reports in those who survived beyond age 10. It is thus unclear how lethal RMND1-related conditions really are. We herein describe the oldest case to have been identified hitherto with this condition, i.e., that of a white female who was 61 at the time of diagnosis but was still active in her everyday life. The gene defect identified was nonetheless associated with many manifestations including ovarian insufficiency and sensorineural hearing loss (two features of what is currently designated as Perrault syndrome) as well as chronic renal failure, asymptomatic myopathy, leukopenia and a few others. In our opinion, this case is of great translational interest for at least three reasons. First, it hints towards the possibility of near-normal life expectancies in some if not many individuals with RMND1 insufficiency. Second, it underlines the wide clinical spectrum associated with this gene. Third, it brings us to question the use of eponyms and syndromic features to identify the true etiology of multisystemic phenotypes.
Enteral L-citrulline supplementation in preterm infants is safe and effective in increasing plasma arginine and citrulline levels – A pilot randomized-controlled trial
Authors: Jain Sunil , Qasim Amna , Bhatia Snigdha , Fuenmayor Maria Franco , Mehdi Mohammad 
Published: April 2023

Abstract
Objective
Deficiencies of citrulline and arginine have been associated with adverse outcomes in preterm-infants (PI) and data regarding enteral supplementation in PI is unknown.
Study Design:
This randomized-controlled-trial [NCT03649932] included 42 PI (gestational age ≤ 33 weeks) randomized to receive enteral L-citrulline in low (100 mg/kg/day), medium (200 mg/kg/day) and high-dose (300 mg/kg/day) groups for 7 days. Plasma citrulline and arginine levels were obtained pre-and-post supplementation and efficacy was determined by a significant increase in levels after supplementation. A p < 0.05 was considered significant. Safety monitoring included blood-pressure-monitoring as well as complications and death during hospitalization.
Results
A total of 40/42 (95%) of the recruits completed the 7-day supplementation with no adverse events. Plasma-citrulline levels increased significantly in all 3 groups while plasma-arginine levels increased significantly in the medium and high-dose groups.
Conclusion
Enteral L-citrulline supplementation in PI is safe and effective in increasing plasma citrulline and arginine levels.
High-Gain Printed Monopole Antenna with Dual-Band Characteristics using FSS- Loading and Top-Hat Structure
Authors: Danuor Patrick , Jung Young-Bae , Moon Jung-Ick 
Published: April 2023

Abstract
This paper presents a high-gain printed monopole antenna with dual-band omnidirectional radiation pattern characteristics for applications in WLAN and IoT sensor networks. The antenna is loaded with a layer of frequency selective surface (FSS) unit cells and a top-hat structure which is seated on top of the dielectric substrate. The proposed antenna structure realizes a high gain without compromising the omnidirectional radiation patterns within the antenna’s operating band. A prototype of the proposed antenna is fabricated where good agreement is achieved between the measured and full-wave simulation results. The proposed antenna attains an impedance bandwidth |S11| < -10 dB at 1.6–2.1 GHz and 2.4–2.85 GHz with a measured peak gain of 5.2 dBi and 6.1 dBi, respectively.
A novel biomarker for Ataxia-Telangiectasia: Evaluating the lack of hypointensity of the dentate nuclei
Authors: Tiet May Yung , Scoffings Daniel J , Blanchard Caroline , Dineen Robert A , Horvath Rita , Hensiek Anke E 
Published: April 2023

Abstract

Ataxia-Telangiectasia (A-T) is a very rare autosomal recessive disease characterised by cerebellar ataxia, extrapyramidal movements and cancer predisposition. Delayed diagnosis is common due to clinical heterogeneity. The development of clinical trials in A-T is limited by a lack of suitable biomarkers. Abnormal hypointensity of the dentate nuclei (DN) has been demonstrated in some genetic ataxias. We assess the degree of hypointensity of the DN in paediatric and adult A-T patients using the Gupta visual ranking score and report a novel observation of a lack of hypointensity of the DN in adults. Adult A-T patients had significantly lower visual rating scores than paediatric patients (0.07 versus 0.55 respectively). Our findings demonstrate that the normal process leading to hypointensity of the DN is initiated in children with A-T, but the physiological DN hypointensity is lost by adulthood.
Preparation of porous silica materials using a eucalyptus template method and its efficient adsorption of methylene blue
Authors: Zhu Wenxin , Liu Leping , Lao YuanXia , He Yan 
Published: April 2023

Abstract
Mesoporous silica has become one of the primary adsorbent materials for solving dye wastewater pollution due to its high specific surface area and good adsorption properties. However, the high cost of the traditional chemical synthesis method limits its wide application. In this thesis, low-cost and high-efficiency porous silica adsorbent materials (PSAM) were successfully prepared by dissolving quartz powder in NaOH solution and depositing and growing in the pores of eucalyptus wood under hydrothermal conditions using eucalyptus wood as a templating agent. The experimental results showed the prepared materials have a loose, porous slit pore structure and many active adsorption sites. The adsorption efficiency of methylene blue was high, reaching more than 85% within 10 min, and the maximum adsorption amount was 90.01 mg/g. The adsorption process was by the pseudo-first-order，pseudo-second-order, and Langmuir models. The analysis of thermodynamic data showed that the adsorption of methylene blue by PSAM was a heat-absorbing process and spontaneous. Therefore, PSAM can be effectively used for the application of methylene blue dye removal in water.
WITHDRAWN: Exploring the features of quanvolutional neural networks for improved image classification
Authors: Tuan Hai Vu , Le Lawrence H , The Bao Pham 
Published: April 2023

Abstract
In several machine learning applications, image classification is a crucial problem. Numerous classification techniques based on quantum machine learning have been presented recently. In this article, we investigate the features of the quanvolutional neural network - a hybrid quantum-classical image classification technique inspired by the convolutional neural network which has the potential to outperform current image processing techniques. We improve the training strategy and evaluate the classification tasks on traditional datasets by different topologies, sizes, and depth of filters. Finally, we propose an efficient configuration for the quanvolutional neural network, making it a promising solution for image classification problems.
Interfacial thermal transport of carbon nanotube on substrate
Authors: Chen Jiao , Hu Baoyi , Wang Zhaoliang 
Published: April 2023

Abstract
Exploring the thermal transport properties of the interface structure of low-dimensional nanomaterials contributes to a deeper understanding of the interface phonon modes and may provide theoretical support for efficient chip cooling devices. In this manuscript, we have simulated in detail the effects of system temperature, substrate location and heat flow density on the thermal transport at the SWCNT/Si interface using the Non-equilibrium Molecular Dynamics approach and predicted the interfacial thermal conductance of SWCNT/Si for second, third and fourth order phonon using the Anharmonic Inelastic model. The results show that the low-frequency acoustic branch of SWCNT is suppressed by phonon scattering from the substrate, and the low-frequency phonon branch of SWCNT is boosted by about 1 THz. The anharmonic channels and inelastic phonon scattering significantly affect the interface phonon modes at higher temperatures, and the anharmonic interactions could increase additional thermal transport channels, which result in an increased number of additional phonon peaks. The increase in temperature gradually consumes the phonons incident at the interface in SWCNT, which enhances the anharmonic scattering and weakens the nonlinear characteristics of the bimaterial heterostructure, while the weakening of the acoustic branch accompanied by the temperature increase makes the LA phonon branch thermal conduction rate slower and the interfacial thermal conductance gradually stabilizes, which leads to the weakening of the thermal rectification effect.
Hydro-thermal Coupling Characteristics of Soil in Loess-Aeolian Sand Coal Mining Subsidence Area During Freezing and Thawing Period
Authors: Dang Xiaohong , Li Peng , Li Xiaole , Liu Jiayue , Gao Yong , Meng Zhongju , Yan Yu 
Published: April 2023

Abstract
Runoff is a valuable water resource during seasonal freezing and thawing period in arid and semi-arid areas, and is of great significance to ecological restoration in coal mining subsidence areas. Through automatic in-situ monitoring of the dynamic changes of soil moisture and temperature inside and outside the coal mining subsidence area of different site types, the spatio-temporal heterogeneity of soil moisture and temperature during freezing and thawing period was analyzed, so that to explore the characteristics of soil moisture and temperature changes in the loess-aeolian mining subsidence area during the seasonal freeze-thaw process in the area connected Shanxi and Inner Mongolia. The results show that: (1) The study area belongs to seasonal frozen soil, and the freezing time is generally from December to March of the following year, and there is a certain hysteresis of soil freezing and thawing to atmospheric temperature. The influence of temperature on soil temperature is mainly concentrated in 0 ~ 40cm topsoil, and such effect intensity is negatively correlated with soil depth. (2) Different types of coal mining subsidence areas have different characteristics in soil Hydro-thermal coupling. The thawing time of the four sites from early to late: outside the loess subsidence area > within the loess subsidence area > outside the aeolian sand subsidence area > within the aeolian sand subsidence area. Among them, soil thawing in the sand and loess coal mining subsidence area lags behind the outside area. 2d. (3) The variation coefficient of soil moisture in the aeolian sand subsidence area during freezing and thawing period ranges from 0.1568 to 0.6271, which is larger than that in the loess subsidence area. Except for the 20-30cm soil layer in the loess coal mining subsidence area, the water content of other soil layers is higher than the outside; while the 0-20cm, surface layer, in the wind-sand coal mining subsidence area has higher soil water content than the 20-60cm layer outside the subsidence area. The water content is lower than outside the subsidence zone. (4) During the freeze-thaw process, the soil temperature and moisture at different depths showed a polynomial function relationship, and the correlation in the surface layer was stronger than that in the deep one. The research results can provide an important reference for understanding the relationship between soil freezing-thawing and hydrological processes in coal mining subsidence areas.
The role of cytoreductive surgery in multifocal/multicentric glioblastomas
Authors: Dimov Diyan , Brainman Daniel , Berger Björn , Coras Roland , Grote Alexander , Simon Matthias 
Published: April 2023

Abstract
Purpose: Multifocal/multicentric glioblastomas (mGBM) account for up to 20% of all newly diagnosed glioblastomas. The present study investigates the impact of cytoreductive surgery on survival and functional outcomes in patients with mGBM.Methods: We retrospectively reviewed clinical and imaging data of 71 patients with newly diagnosed primary (IDH1 wildtype) mGBM who underwent operative treatment in 2015–2020 at the authors’ institution. Multicentric/multifocal growth was defined by the presence of ≥ 2 contrast enhancing lesions ≥ 1 cm apart from each other.Results: 36 (50.7%) patients had a resection and 35 (49.3%) a biopsy procedure. MGMT status, age, preoperative KPI and NANO scores as well as the postoperative KPI and NANO scores did not differ significantly between resected and biopsied cases. Median overall survival was 6.4 months and varied significantly with the extent of resection (GTR: 13.6, STR: 6.4, biopsy: 3.4 months; P = 0.043). 21 (58.3%) of resected vs. only 12 (34.3%) of biopsied cases had radiochemotherapy (p = 0.022). Multivariate analysis revealed chemo- and radiotherapy and also (albeit with smaller hazard ratios) extent of resection (resection vs. biopsy) and multicentric growth as independent predictors of patient survival. Involvement of eleoquent brain regions, as well as neurodeficit rates and functional outcomes did not vary significantly between the biopsy and the resection cohorts.Conclusion: Resective surgery in mGBM is associated with better survival. This benefit seems to relate prominently to an increased number of patients being able to tolerate effective adjuvant therapies after tumor resections. In addition, cytoreductive surgery may have a survival impact per se.
Exploring Factors Affecting User Satisfaction and Behavioral Intention towards Telemedicine Services among Gen-Z and Millennials in Indonesia: A PLS-SEM Study on Alodokter Application
Authors: Pramudita Eka , Achmadi Hendra , Nurhaida Hansa 
Published: April 2023

Abstract
Telemedicine has become increasingly important in healthcare, especially with the COVID-19 pandemic. Alodokter, one of the pioneers of health applications providing telemedicine services in Indonesia since 2014, has gained significant attention. Younger generations–Millennials and Gen Z–are more fluent in using technology. However, previous study shows that older generations (Gen X) is more satisfied in using telemedicine compared to younger generations. This study aims to identify the factors influencing user satisfaction and behavioral intention towards Alodokter's telemedicine service application usage among Millennials and Gen-Z in Indonesia. A survey was conducted on 160 respondents using a purposive sampling technique. The data was analyzed using the PLS-SEM based method with the SmartPLS MacOS application version 3.2.9. The study focused on examining the relationships between the variables of behavioral intention, customer satisfaction, and factors including performance expectancy, effort expectancy, price value, and social influence. The study findings indicate that customer satisfaction positively affects behavioral intention. Performance expectancy, effort expectancy, price value, and social influence positively impact customer satisfaction. Price value was shown to have the most positive influence on behavioral intention. The study provides insights into the factors influencing user satisfaction and behavioral intention towards telemedicine service application usage among younger generations in Indonesia. The results can be used to improve telemedicine services and enhance the experience of users, particularly Millennials and Gen-Z.
Effect of additives on the microstructure and properties of electrolytic copper foils
Authors: Liu Jingpei , Sun Wanchang , Bai Zhongbo , Liu Eryong , Cai Hui , Tian Shasha , Zhang Congxiao , Xu Yifan , Zhang Bo , Zhou Mengran 
Published: April 2023

Abstract
A low-roughness ultra-thin copper foil was prepared by pulsed electrodeposition on titanium substrate. The influence of sodium 3,3'-dithiodipropane sulfonate (SPS), hydroxyethyl cellulose (HEC), gelatin and collagen additives on the microstructure, mechanical properties and electrochemical behavior of electrolytic copper foil was explored. Furthermore, the reaction mechanism of SPS and collagen additives on electrodeposited copper was discussed. The results showed that at 0.08 g/L collagen concentration, the lowest thickness, the highest microhardness and the optimal surface roughness were achieved to be 5.12 µm, 279.63 HV0.05 and 1.885 µm, respectively. X-ray diffraction results confirmed that electrolytic copper foils prepared by SPS was introduced into the blank solution had a preferred orientation of (220) texture, which benefitted from the synergistic effect of copper ions and additives. The intermediates formed by the additive and Cu+ occupied the active sites on the cathode surface that increased nucleation sites for deposition. Besides, the formed complexes can act as a barrier to narrow ion deposition channels and inhibit the growth of Cu ions.
Untangling the role of optimism, pessimism and coping influences on student mood, motivation and satisfaction.
Authors: Gibbons Chris 
Published: April 2023

Abstract
The aims explored the associations between stress and eustress ratings and influences on coping (control, support and personality), on mood, course satisfaction and learning motivation. Undergraduate students, (N = 175), were surveyed on student stressors, personality, support and control against mood, course satisfaction and motivation. Defensive pessimism, context control and agreeableness lowered anxiety, while neuroticism, extraversion and hassle ratings of tutor support, increased it. Control and neuroticism mediated between the hassle ratings accorded to support from family and friends and anxiety. Optimism and defensive pessimism lowered depression scores. Those in the upper quartile on Defensive pessimism, compared to those in the upper quartile on optimism, scored lower on anxiety, higher on learning motivation and course satisfaction and this is despite the optimism group being higher in self-efficacy, control and conscientiousness. Both groups scored higher than the cohort average on GPA, with the upper quartile in optimism, highest. The results suggest context control, defensive pessimism and optimism all offer effective coping, with individual difference an important caveat – for those capable and high in anxiety, defensive pessimism was effective. An optimistic outlook is unlikely to be helpful. It may even have negatives, while optimistic thinking strategies together with defensive pessimism are likely to boost motivation, satisfaction and mood.
Psoriasis and cardiovascular comorbidity – a mutually aggravating relationship
Authors: Kovaleva Yu. S. , Vedler A. A. 
Published: April 2023

Introduction. The systemic psoriatic process affects not only the skin, but also other organ systems, including the cardiovascular system. Immunopathological inflammation that occurs in the skin and articular tissues is a central link in the pathology of the cardiovascular system in psoriasis.Objective. Identify diseases of the cardiovascular system and factors of their development in patients with psoriasis and to assess their severity depending on the severity of dermatosis.Materials and methods. The study included 406 patients with psoriasis aged 18 to 74 years, who were divided into three subgroups depending on the severity of the course. Assessment of the state of the cardiovascular system was carried out using the following methods: uestionnaire, clinical, physical, laboratory and statistical. The comparison group consisted of 200 people.Results. In 53.9% of patients, psoriasis occurred against the background of cardiovascular comorbidity. More than 90% of patients with moderate to severe psoriasis have more than three risk factors for CCC diseases. Patients are more susceptible to the development of hypertension, hypercholesterolemia, obesity, abdominal obesity, stress and smoking. The higher the cardiovascular risk, the more severe psoriasis is.Conclusions. The presence of unmodified and modifiable risk factors for the development of cardiovascular diseases is aggravating for the course of psoriasis, which means that the risk of undesirable fatal events is higher. Patients with psoriasis need additional preventive measures aimed at preventing the development of cardiovascular pathology.
TRATAMIENTO ANAEROBIO Y VALORIZACIÓN ENERGÉTICA DE LAS AGUAS RESIDUALES DEL PROCESO DE NIXTAMALIZACIÓN DEL MAÍZ: UNA REVISIÓN
Authors: Vázquez-López Monserrat , Jiménez-Ocampo Ulises Emmanuel , Moreno-Andrade Iván 
Published: April 2023

La generación de aguas residuales de la industria de nixtamalización del maíz (conocida como nejayote) en México asciende a 14.4 millones de m3/año. Este tipo de aguas residuales se distinguen por tener un pH alcalino >10, alto contenido de materia orgánica (33.2 gDQO/L en promedio) y una relación DBO5/DQO de 0.4, indicando que corresponde a un residuo con alta biodegradabilidad a través de su tratamiento por procesos biológicos anaerobios con valorización energética. En este sentido, la fermentación oscura y la digestión anaerobia son procesos que ofrecen alternativas de aprovechamiento de esta agua residual, ya que además de estabilizar el residuo, genera subproductos de valor agregado como los ácidos grasos volátiles, metano, hidrógeno y digestato. Pocas investigaciones se han centrado en la producción de biogás a partir del nejayote, reportando rendimientos máximos de 282 mLCH4/gDQO y 49.3 NmLH2/gDQO, remociones entre el 50% hasta el 95% en términos de DQO. La valorización energética del agua residual de la nixtamalización tiene un potencial energético que puede alcanzar hasta 20.4 kWh/m3 , la cual puede ser utilizada para cubrir el requerimiento energético de los equipos dinámicos y servicios auxiliares dentro del tratamiento y el remante puede ser utilizado dentro del giro industrial.
The Broader Economic Value of Treatment for Diabetic Macular Edema
Authors: Mulligan Karen , Kim Jaehong , Tysinger Bryan , Blim Jill , Emerson Geoffrey , Ferrone Philip J. , Kim Judy E. , Seabury Seth , Hahn Paul 
Published: April 2023

OBJECTIVE
To simulate economic outcomes for individuals with diabetic macular edema (DME) and estimate the economic value of direct and indirect benefits associated with DME treatment.

RESEARCH DESIGN AND METHODS
Our study pairs individual and cohort analyses to demonstrate the value of treatment for DME. We used a microsimulation model to simulate self-reported vision (SRV) and economic outcomes for individuals with DME. Four scenarios derived from clinical trial data were simulated and compared for a lifetime horizon: untreated, anti-VEGF therapy, laser, and steroid. To quantify the relative magnitude of costs and benefits of DME treatment in the U.S., we used a cohort-level analysis based on real-world treatment parameters derived from published data.

RESULTS
In the model, excellent/good SRV roughly corresponded to 20/40 or better visual acuity. A representative 51-year-old treated for DME would spend 30–35% additional years with excellent/good SRV and 29–32% fewer years with fair/poor SRV relative to being untreated. A treated individual would experience 4–5% greater life expectancy and 9–13% more quality-adjusted life-years. Indirect benefits from treatment included 6–9% more years working, 12–19% greater lifetime earnings, and 8–16% fewer years with disability. For the U.S. DME cohort (1.1. million people), total direct benefit was $63.0 billion over 20 years, and total indirect benefit was $4.8 billion. Net value (benefit − cost) of treatment ranged from $28.1 billion to $52.8 billion.

CONCLUSIONS
Treatment for DME provides economic value to patients and society through improved vision, life expectancy, and quality of life and indirectly through improved employment and disability outcomes.