bluuebunny/crossref_metadata_2025_split huggingface dataset:
TMEM151A Variants Associated with Paroxysmal Kinesigenic Dyskinesia
Authors: Huang Hualin , Zhang Qingxia , Huang Fei , Long Xiaoyan , Song Zhi , Xiao Bo , Li Guoliang , Ma Caiyu , Liu Ding 
Published: December 2022

Abstract
TMEM151A, located at 11q13.2 and encoding transmembrane protein 151A, was recently reported as causative for autosomal dominant paroxysmal kinesigenic dyskinesia (PKD). Here, through comprehensive analysis of sporadic and familial cases, we expand the clinical and mutation spectrum of PKD. In doing so, we clarify the clinical and genetic features of Chinese PKD patients harboring TMEM151A variants and further explore the relationship between TMEM151A mutations and PKD. Whole exome sequencing was performed on 26 sporadic PKD patients and nine familial PKD pedigrees without PRRT2 variants. Quantitative real-time PCR was used to assess the gene expression of frameshift mutant TMEM151A in a PKD patient. TMEM151A variants reported to date were reviewed. Four TMEM151A variants were detected in four unrelated families with 12 individuals, including a frameshift mutation [c.606_607insA (p.Val203fs)], two missense mutations [c.166G > A (p.Gly56Arg) and c.791T > C (p.Val264Ala)], and a non-pathogenic variant [c.994G > A (p.Gly332Arg)]. The monoallelic frameshift mutation (c.606_607insA) may cause TMEM151A mRNA decay, suggesting a potential pathogenic mechanism of haploinsufficiency. Patients with TMEM151A variants had short-duration attacks and presented with dystonia. Our study provides a detailed clinical description of PKD patients with TMEM151A mutations and reports a new disease-causing mutation, expanding the known phenotypes caused by TMEM151A mutations and providing further detail about the pathoetiology of PKD.
Discrimination of groundwater mineralization process in the Jemna oases (southwestern Tunisia) between anthropogenic effect and evaporate dissolution
Authors: ELhamdi Rafika , Bencheikh Narjess , Moumni Yahya , Boukchina Rachid 
Published: December 2022

Abstract
Southern Tunisia is characterized by high temperatures, scarcity of rainfall (less than 90 mm/year), and high evaporation. In such an arid environment, most oases are developed thanks to groundwater springs and deep wells in artesian aquifers. Located in the southwestern part of Tunisia, the Jemna oases are considered among the most important palm groves in the country. In recent years, various modernization interventions and significant financial resources have been mobilized in this area to produce groundwater from the Continental Intercalaire (CI) and the Complex Terminal (CT) aquifers to supply the ever- increasing demand for water for agricultural activities. However, the overexploitation of these aquifers has led to the decline of groundwater heads and, therefore, a drying up of most natural springs. The results show that the dissolution of evaporitic minerals constitutes the principal cause of the observed groundwater mineralization. These salinization problems were greatly accentuated by local corrosion of the casing of a central groundwater production well exploiting the CI 11 aquifer in 2014. Since this date, the problem of contamination seems to have reached all the surrounding shallower aquifers. Caused by several combined anthropogenic and geological factors, the degradation of groundwater quality in this arid region constitutes a serious risk of limitation of water resources and even the extinction of the Jemna oases. Combined isotopic and hydrochemical investigations were conducted to understand the hydrodynamic characteristics of the different aquifer systems in the Jemna area and identify the main factors and mechanisms that control groundwater mineralization.The isotopic data highlights the significant mixing of waters from underlying aquiferes in realtion to the geological complexity of the region.
Lacunary Summability and Lacunary Statistical Convergence Concepts in Partial Metric Spaces
Authors: Gülle Esra , Dündar Erdinç , Ulusu Uğur 
Published: December 2022

Abstract
In this study, firstly, we introduce the concepts of strong lacunary and strong q-lacunary summability in the partial metric space (X, p) and then, we give some properties and theorems related with these concepts. Also, we present the concept of lacunary statistical convergence in the partial metric space (X, p) and examine some relations.
Influence of Logistics Management on Availability and Affordability of Antihypertensive Medicines in Rwanda. Case Study: RMS Ltd and District Hospitals
Authors: Cyprien NTIBIRINGIRWA 
Published: December 2022

AbstractBackground Hypertension is one of the five causes of death globally, and it is a significant risk factor in more than 40% of deaths from cardiovascular and renal diseases [1]. The management of patients with hypertension requires the availability and affordability of medicines used to prevent and treat hypertension to achieve universal health coverage by 2030, as well as Rwanda's ministry of health strategic plan 2019–2024 of achieving 90% target of availability of essential medicines, including ones used for management of hypertension. Method In this study, a descriptive, cross-sectional study was undertaken in 14 public district hospitals, one central medical store, and its 30 branches across the country. Data was collected using excel sheets for surveyed antihypertensive medicines, and questionnaires were sent to all respondents. SPSS Version 22 and advanced excel were used to analyze the data. The treatment of affordability was evaluated by comparing if the patient's contribution to the total treatment was less than their daily salary wages. Results The overall availability of 15 selected antihypertensive medicines was 65%, 64%, and 71% for central medical stores, district stores, and district hospitals, respectively, compared to 80% targeted by WHO and 95% HSSP IV. Only 33.4% of individual items, the availability was greater than 83% and met the WHO target of 80%. The results have shown that stock levels were 40%, 28%, 83% and 20%, 21%, and 0% at maximum and minimum levels for RMS branches, district hospitals, and RMS for the central level, respectively. The results have shown that all surveyed antihypertensives was affordable. Conclusion The availability of antihypertensive medicines remains a challenge in Rwanda's health supply chain, though they are affordable. Therefore, more efforts and improvements are needed to increase the availability of antihypertensive medicines to provide quality health care to patients in need.
Implementing Mindfulness at Work: qualitative study about integrating mindfulness digitally supported into the large corporation setting by using systems theory
Authors: Wrede Sammy J.S. , Sobke Sophie C. , Michaelsen Maren M. , Esch Tobias 
Published: December 2022

Abstract
Current research states the benefits of implementing mindfulness within the workplace. In large corporations, financial and personnel resources for a mindfulness-based intervention may exist, but successfully implementing interventions within a corporation may also require a change in the workplace culture as a whole. This study aims to depict the integration of a mindfulness-based intervention in a digitally augmented setting in order to promote mindfulness in the digital workplace. Because change in an organization cannot be managed one-dimensional, systems theory is implemented within this study in order to meet the requirements of a complex system. Interviews with experts working in or with large companies on the topic of mindfulness in new work contexts reveal an integration process. Subsequently, information is extracted from the interviews and the content is qualitatively analysed to find answers to the research question. Differentiated results from a) employees, b) employers, and c) consultants perspective, with information about input (1.), throughput (2.), and output (3.) of a mindfulness-based intervention in the corporate setting were stated, e.g., with respect to communication by using the employees’ language as well as internal resources such as social media and communication platforms. Guidelines for implementing digitally-supported mindfulness at work are derived and discussed.
Modeling the Impact of Mentoring on Women’s Work-Life Balance: A Grounded Theory Approach
Authors: Bahrami Parvaneh , Nosratabadi Saeed , Palouzian Khodayar , Hegedűs Szilárd 
Published: December 2022

Abstract
The purpose of this study was to model the impact of mentoring on women’s work-life balance. Indeed, this study considered mentoring as a solution to create a work-life balance of women. For this purpose, semi-structured interviews with both mentors and mentees of Tehran Municipality were conducted and the collected data were analyzed using constructivist grounded theory. Findings provided a model of how mentoring affects women's work-life balance. According to this model, role management is the key criterion for balancing work-life of women. In this model, antecedents of role management and the contextual factors affecting role management, the constraints of mentoring in the organization, as well as the consequences of effective mentoring in the organization are described. The findings of this research contribute to the mentoring literature as well as to the role management literature and provide recommendations for organizations and for future research.
Comparison of carcass condemnation causes in two broiler hybrids differing in growth rates
Authors: Forseth Merete , Moe Randi Oppermann , Kittelsen Käthe , Skjerve Eystein , Toftaker Ingrid 
Published: December 2022

Abstract
Experimental studies concluded that genetic factors enabling fast growth rate might negatively affect broiler health and welfare. Recently, the proportion of slower-growing broilers has been increasing. However, studies of health in broilers with different growth rates in commercial systems are still scarce. This repeated cross-sectional study aimed to describe causes of carcass condemnations in two broiler hybrids with different growth rates, Ross 308, and Hubbard JA787, and to estimate the effect of hybrid. The study sample consisted of 63 209 415 broilers slaughtered in 4295 batches from 139 farms. All broilers were slaughtered from January 1st, 2015, to June 22nd, 2021, by the same company (Norsk Kylling). All causes of condemnation, except fractures, were more prevalent in Ross 308. The five most common causes (ascites, discolouration, hepatitis, small and skin lesions) were investigated in greater detail, and the effect of hybrid was assessed using mixed effects negative binomial models with the condemnation codes as outcome variables. For the five selected causes, variation in prevalence between slaughter batches was considerable for Ross and minor for Hubbard. The notable differences between hybrids in prevalence and causes of condemnation have important implications for animal health, welfare, economy, and sustainability in broiler production.
The Synergetic Effect of Sitafloxacin-Arbekacin Combination in the Mycobacterium abscessus Species
Authors: Watanabe Junko , Ihara Hiroaki , Takei Satomi , Nakamura Ayako , Fujimoto Yuichi , Handoh Tetsuya , Kurokawa Kana , Arai Yuta , Shibayama Kohei , Sumiyoshi Issei , Ochi Yusuke , Okabe Takahiro , Misawa Shigeki , Togo Shinsaku , Naito Toshio , Tabe Yoko , Miida Takashi , Takahashi Kazuhisa 
Published: December 2022

Abstract
Mycobacterium abscessus species (MABS) is the most commonly isolated rapidly growing mycobacteria (RGM) and is one of the most antibiotic-resistant RGM with rapid progression, therefore, treatment of MABS is still challenging. We here presented a new combination treatment with sitafloxacin that targeted rough morphotypes of MABS, causing aggressive infections. Thirty-four clinical strains of MABS were isolated from various clinical samples at the Juntendo university hospital from 2011 to 2020. The susceptibility to a combination of sitafloxacin and antimicrobial agents was compared to that of the antimicrobial agents alone. Out of 34 MABS, 8 strains treated with sitafloxacin-amikacin combination, 9 of sitafloxacin-imipenem combination, 19 of sitafloxacin-arbekacin combination, and 9 of sitafloxacin-clarithromycin combination showed synergistic effects, respectively. Sitafloxacin-arbekacin combination also exhibited the synergistic effects against 10 of 22 Mycobacterium abscessus subspecies massiliense (Mma) strains and 8 of 11 Mycobacterium abscessus subspecies abscessus (Mab) strains, a highly resistant subspecies of MABS. The sitafloxacin-arbekacin combination revealed more synergistic effects in rough morphotypes of MABS (p = 0.008). We demonstrated the synergistic effect of the sitafloxacin-arbekacin combination against MABS. Further, this combination regimen might be more effective against Mab or rough morphotypes of MABS.
Effect of Yeast Biosorbents on Wine Quality
Authors: Ageyeva Natalia , Tikhonova Anastasia , Burtsev Boris , Khrapov Anton 
Published: December 2022

Foreign food industries know a variety of products derived from wine yeast cells. These products are used to improve the sensory properties of wine. This article describes the effect of a new yeast biosorbent on the sensory and physicochemical properties of white and red wine, e.g., their sorption capacity for heavy metals.
The research featured red and white wines treated with the novel biosorbent. Glutarom (France) served as control. The study relied on various physicochemical, organoleptic, biochemical, and microbiological methods.
The biosorbent affected neither the volume fraction of ethyl alcohol nor the mass concentration of sugars and titrated acids. However, the biosorbent reduced the mass concentration of volatile acids in terms of acetic acid: it decreased by 20% in the white wines and by 50% in the red wine samples. The mass concentration of the reduced extract decreased by 0.2–0.7 g/dm3 as the amount of sorbent increased. In the white wine samples, the protein concentration decreased by 1.5–1.8 times, while the concentration of polysaccharides decreased by 110–115 mg/dm3. The content of phenolic compounds decreased by 13–37%, depending on the amount of the sorbent, due to their condensed forms. The biosorbent reduced the value of the redox potential. The yeast sorbents effectively adsorbed metal cations, including those of heavy metals. A set of experiments also revealed the difference in sorption time for different metal cations. The effectiveness of the biosorbent was dose-dependent. The wines treated with the biosorbent had better sensory assessment results, especially the red wine samples. They had a soft, round, and harmonious flavor and a bright aroma with pronounced varietal tones.
The novel biosorbent proved to have a good sorption capacity for phenolic compounds, as well as cations of toxic metals. It improved the sensory profile of the red and white wines. This biosorbent can substitute their imported analogs in the Russian wine industry.
Acidification in Distillation Technology
Authors: Krikunova Ludmila , Dubinina Elena , Peschanskaya Violetta , Obodeeva Olga 
Published: December 2022

The quality of distillates depends on the biochemical composition of the raw material, the operating parameters of the wort production and fermentation, and the methods and modes of distillation. The active acidity of the medium (pH) can affect wort fermentation and distillation processes. The research objective was to study the effect of the active acidity of bakery waste wort on fermentation and distillation processes.
The study featured fermented wort samples from wheat bread, a mix of wheat and rye-wheat bread, and distillate fractions obtained by a single fractionated distillation of fermented wort. The distillation occurred in laboratory conditions in a direct distillation unit (Kothe Destillationstechnik, Germany) with a 10 dm3 cube. The effect of the acidification degree of saccharified wort on the fermentation efficiency was determined by the strength of the fermented wort. The composition of volatile components in the distillates was defined by gas chromatography in a Thermo Trace GC Ultra chromatograph (Thermo, USA).
When the pH of saccharified wort fell from 5.5 to 4.5–3.5, the synthesis of higher alcohols and ethers of higher fatty acids decreased during fermentation, while the acetone mass concentration increased. The acidification of fermented wort to pH = 3.5–3.0 at the distillation stage had a positive effect on the distillates from recyclable baking waste. This technique increased the yield of the middle fraction (distillate) by reducing the loss of absolute alcohol with the head and tail fractions. The concentration of acetaldehyde and ethyl acetate in the middle fraction decreased by 1.5 times while the content of enanthic ether components increased by more than 75%. As a result, the sensory profile increased by 0.4–0.5 points. The distillates from the mix of wheat and rye-wheat bread were superior to distillates from wheat bread. The statistical analysis provided the following criteria for a qualitative assessment of the distillates from recyclable baking waste: the mass concentration of acetaldehyde and the ratio of alcohols C5 to the sum of alcohols C3 and C4.
Pre-fermentation oxidation of saccharified wort proved impractical for bakery waste recycling, whereas acidification of fermented wort before distillation increased the distillate yield and improved its sensory profile.
Sustainable Raw Material Base as a Factor of Competitiveness of Cheese-Making Enterprises
Authors: Panasenko Svetlana , Suray Natalya , Tatochenko Alexander , Rodinova Nadezhda , Ostrouhov Vladimir 
Published: December 2022

Russian cheese producers strive to increase their production. A sustainable best-experience raw material base can solve this problem. The authors analyzed the raw material supply in the leading cheese-producing countries in order to develop a system of new targets for Russian cheesemakers.
The study featured the performance indicators of the world's leading cheese producers in terms of raw material supply. It relied on scientific, regulatory, and legislative documents. The study also included databases (2017–2022) published by the Federal State Statistics Service, the dairy economic consulting firm CLAL, and the Atlas Big site of international and regional data statistics. The data were processed by statistical methods, e.g., generalization, systematization, distribution, etc., and econometrics, e.g., correlation, regression analysis, etc. The authors calculated the statistical characteristics of raw material supply indicators, assessed the interfactorial relationships, and obtained regression equations to describe these relationships in quantitative terms.
The calculations involved the volumes of total and per capita cheese production in various regions of the world. The group of leaders included twenty countries with an average production per capita of 26.5 kg. The key indicators of raw material supply included milk production per capita, livestock, structure, and milk cattle productivity. The research revealed some raw material problems in the domestic cheese industry. For instance, domestic milk production per capita (206.3 kg) is below the average for the leading countries (489.4 kg). This issue is associated with the low milk cattle productivity, which is 4492 kg in the Russian Federation and 7061 kg in the leading cheese-producing countries. The regression equations used determination coefficients of ≥ 0.8 to calculate the main parameters of the domestic cheese-making base that would meet dairy food security criteria. A milk production of 388 kg per capita proved to be the minimal amount that would guarantee food security in the domestic cheese sector. However, the existing number of cows (7.9 million) means that the milk productivity cannot fall below 7146 kg. The required value can be obtained by improving diets and selection.
The analytical methods developed in this research provided highly reliable results. These results can solve the problems of providing Russian cheesemakers with a sustainable raw material base, as well as set new targets for agro-industrial dairy enterprises.
Functional Food Market Analysis: Russian and International Aspects
Authors: Moliboga Elena , Sukhostav Elizaveta , Kozlova Oksana , Zinich Alla 
Published: December 2022

The modern food market is undergoing a period of rapid development following the changes in marketing technologies and consumer behavior patterns. Nowadays, people pay more attention to the quality and composition of food products, as well as their functional properties. The present article reviews the international and Russian market of functional foods in order to define the consumer demand for new specialized products.
The methods included data comparison, grouping, and systematization. The analysis involved Russian and foreign papers published in 2018–2022 and registered in Scopus, eLibrary, Cyberleninka, and the Library of the Russian Foundation for Basic Research. It also covered the National Demography Project, the Healthy Nutrition Project, and the Strategy for Improving the Quality of Food Products through 2030.
Consumers’ growing interest in improving their health and immune system proved to be the key factor in the functional food market. The COVID-19 pandemic intensified such trends as the priority of healthy, high-protein, and low-sugar foods. Japan and the USA are the current leaders on this market. Russia supports healthy food policy at the state level.
The functional food market is likely to become the most promising and competitive sector of global food economy. Consumer demand for these products is steadily growing: the volume of demand for functional food products will reach 17 trillion rubles by 2027. However, Russian food science needs more research in this area to catalyze import substitution. The Omsk Agrarian University has numerous projects that are meant to increase the competitiveness of the domestic functional food industry.
Confectionery Standards in the Eurasian Economic Union
Authors: Demchenko Elena 
Published: December 2022

A barrier-free trade in the Eurasian Economic Union (EAEU) market is impossible without a unified approach to standardization. The research objective was to analyze and develop proposals that would make it possible to unify the standards of the Eurasian Economic Commission (EAEC) on the content of sulfur dioxide and sulfites in confectionery products.
The study featured technical regulations and standards for confectionery products, methods for determining sulfur dioxide, and EAEU resources on the results of control oversight activities. The methods included comparison, analogy, analysis, synthesis, peer review, integrated standardization, and system analysis.
The analysis involved the official websites of the authorized bodies of the EAEU states on control and supervisory measures for compliance with technical regulations. It revealed the main reasons behind the limited confectionery turnover associated with excessive sulfur dioxide and sulfites. The standards showed discrepancies with Technical Regulations of Customs Union TR CU 022/2011 and TR CU 029/2012. The content standards for sulfur dioxide and sulfites in finished products were different. The analysis detected no unified approach to indicators, measurement units, and detection methods. The authors also assessed the advantages and disadvantages of the existing domestic State Standards for methods of sulfur dioxide and sulfite detection in confectionery products. The state standards have to be adapted to the international standards and EU Directives, in particular, by certifying the Monier-Williams method.
The results can help to unify national and international regulations in order to remove technical barriers in the EAEU market and increase the export volume. They also can help confectionery producers to improve the quality and safety of confectionery products.