bluuebunny/crossref_metadata_2025_split huggingface dataset:
Registration of ‘S16‐5503GT’ soybean cultivar with high yield, broad adaptation, and glyphosate tolerance
Authors: Chen P. , Ali M. L. , Shannon G. , Vieira C. C. , Lee Y.‐C. , Nascimento E. F. , Granja M. O. , Lee D. , Crisel M. , Smothers S. , Clubb M. , Selves S. , Scaboo A. , Usovsky M. , Nguyen H. T. , Li Z. , Mitchum M. G. , Averitt B. , Bond J. , Meinhardt C. , Li S. , Gillen A. M. , Mengistu A. , Robbins R. T. , Mozzoni L. A. , Zhang B. , Smith J. R. , Moseley D. 
Published: January 2023

Abstract‘S16‐5503GT’ (Reg. no. CV‐555, PI 700002) is a semi‐determinate, late‐maturity group IV (relative maturity, 4.8), glyphosate‐tolerant, high‐yielding soybean [Glycine max (L.) Merr.] cultivar developed and released in 2021 by the University of Missouri‐Fisher Delta Research, Extension, and Education Center (MU‐FDREEC) soybean breeding program. Southern U.S. growers’ preference for high‐yielding, early‐maturing cultivars with glyphosate tolerance and broad disease resistance motivated the development of S16‐5503GT soybean. It was evaluated in a total of 92 environments across 12 U.S. mid‐southern states from 2017 to 2021 for yield and agronomic traits. Across all testing environments, S16‐5503GT yielded 4,258 kg ha−1, which was equivalent to 108% of the non‐Xtend check mean and 102% of the Xtend check mean, ranking in the top 19% overall. In the 2021 Southern State Variety Trials, S16‐5503GT yielded 4,455 kg ha−1 and ranked in the top 43% overall. S16‐5503GT is resistant to soybean cyst nematode races 3 (HG type 5.7) and 5 (HG type 2.5.7) and moderately resistant to race 2 (HG type 1.2.5.7). It is also resistant to southern root‐knot nematode, reniform nematode, frogeye leaf spot, charcoal rot, and brown stem rot and is tolerant to extreme salinity conditions. The broad disease resistance package combined with high‐yielding performance and wide adaptability across multiple mid‐southern states make S16‐5503GT an excellent cultivar choice for soybean growers in the southern United States, where late‐maturity group IV varieties are in demand.
Effect of chemotherapy (with and without radiotherapy) on the intelligence of children and adolescents treated for acute lymphoblastic leukemia; a meta‐analysis
Authors: Cao Shu‐Chun , Legerstee Jeroen S. , van Bellinghen Marc , Lemiere Jurgen , Sleurs Charlotte , Segers Heidi , Danckaerts Marina , Dierckx Bram 
Published: January 2023

AbstractObjectiveThis meta‐analysis assesses cognitive functioning in children with acute lymphoblastic leukemia post‐treatment who were treated with either chemotherapy‐only (CT‐only) or in combination with radiation therapy (CTRT).MethodsThe databases Pubmed and PsychInfo were searched between 1‐1‐2000 and 31‐12‐2021. Data were analyzed using Comprehensive Meta‐Analysis (version 2).ResultsMean weighted intelligence after treatment was 100.2 (number of studies n = 51, 95% CI: 98.8–101.5). For CT‐only, it was 100.8 (95% CI: 99.5–102.2) and for CTRT 97.8 (95% CI: 95.9–100.2). Compared to recruited healthy controls, treated children had on average lower IQ scores (n = 23, mean difference −7.8, 95% CI: −10.7 to −5.0, p < 0.001). When looking only at studies using controls recruited from the patient's family, results remained significant (n = 5, mean difference −6.0, 95% CI: −8.6 to −3.5, p = 0.001). Meta‐regressions aimed at identifying predictors of IQ after treatment failed to find an effect for sex or age. We could demonstrate an effect of time between diagnosis and IQ measurement for the CTRT treated patient (B = −0.26, 95% CI: −0.40 to −0.1, p = 0.002).ConclusionsIQ scores of patients treated with CT‐only or CTRT treatment regimens did not differ from the normative population. However, compared to recruited control groups, patients showed lower mean IQ scores. The Flynn effect and/or selection effects may play a role in this discrepancy. Considering time since diagnosis may have a significant impact on IQ, at least in CTRT treated patients, long‐term clinical follow‐up of neurocognitive development may be prudent to detect possible (late) neurocognitive effects.
A qualitative study of patients with Cancer of Unknown Primary: Perceptions of communication, understanding of diagnosis and genomic testing, and information needs
Authors: Wolyniec Kamil , O’Callaghan Clare , Fisher Krista , Jessica Sharp , Tothill Richard W. , Bowtell David , Linda Mileshkin , Schofield Penelope 
Published: January 2023

AbstractObjectivePatients with Cancer of Unknown Primary (CUP) commonly report poor understanding of their illness and high levels of psychological distress. Despite the potential benefits to CUP patients, there is a paucity of research exploring the reasons behind poor understanding of a CUP diagnosis. The aim of this study was to understand patients' experiences of communication with doctors, their understanding of diagnosis and the role of genomic testing, as well as their information needs.MethodsSemi‐structured interviews explored CUP patients' perceptions of communication with their doctors, understanding of their illness, and their needs regarding medical information. Qualitative inductive thematic analysis of transcribed audio‐recordings was employed.Setting/ParticipantsNineteen patients were recruited from within a prospective cohort study involving routine genomic testing of CUP patients.ResultsCUP patients had varied perceptions of communication with doctors as well as different levels of need, readiness, and capacity for information. Some patients felt well understood and supported by their doctors while others did not. Many patients reported feeling overwhelmed and shocked when receiving their cancer diagnosis and emphasized the importance of family support in receiving and understanding medical information. While patients understood the implications of genomic testing for treatment and diagnosis, few had a detailed understanding of genomic testing.ConclusionsPatients' experience of communication and understanding of CUP could be potentially improved by clinicians' assessment of the communication style preferred by each patient and their family and the development of online resources to meet their evolving information needs.
Dissecting the genetic architecture of leaf morphology traits in mungbean (Vigna radiata (L.) Wizcek) using genome‐wide association study
Authors: Chiteri Kevin O. , Chiranjeevi Shivani , Jubery Talukder Zaki , Rairdin Ashlyn , Dutta Somak , Ganapathysubramanian Baskar , Singh Arti 
Published: January 2023

AbstractMungbean (Vigna radiata (L.) Wizcek) is an important pulse crop, increasingly used as a source of protein, fiber, low fat, carbohydrates, minerals, and bioactive compounds in human diets. Mungbean is a dicot plant with trifoliate leaves. The primary component of many plant functions, including photosynthesis, light interception, and canopy structure, are leaves. The objectives were to investigate leaf morphological attributes, use image analysis to extract leaf morphological traits from photos from the Iowa Mungbean Diversity (IMD) panel, create a regression model to predict leaflet area, and undertake association mapping. We collected over 5000 leaf images of the IMD panel consisting of 484 accessions over 2 years (2020 and 2021) with two replications per experiment. Leaf traits were extracted using image analysis, analyzed, and used for association mapping. Morphological diversity included leaflet type (oval or lobed), leaflet size (small, medium, large), lobed angle (shallow, deep), and vein coloration (green, purple). A regression model was developed to predict each ovate leaflet's area (adjusted R2 = 0.97; residual standard errors of < = 1.10). The candidate genes Vradi01g07560, Vradi05g01240, Vradi02g05730, and Vradi03g00440 are associated with multiple traits (length, width, perimeter, and area) across the leaflets (left, terminal, and right). These are suitable candidate genes for further investigation in their role in leaf development, growth, and function. Future studies will be needed to correlate the observed traits discussed here with yield or important agronomic traits for use as phenotypic or genotypic markers in marker‐aided selection methods for mungbean crop improvement.
Structural investigation of CDCA3‐Cdh1 protein–protein interactions using in vitro studies and molecular dynamics simulation
Authors: Barbhuiya Tabassum Khair , Fisher Mark , Boittier Eric D. , Bolderson Emma , O'Byrne Kenneth J. , Richard Derek J. , Adams Mark Nathaniel , Gandhi Neha S. 
Published: January 2023

AbstractThe anaphase‐promoting complex/cyclosome (APC/C) ubiquitin ligase and its cofactor, Cdh1, regulate the expression of several cell‐cycle proteins and their functions during mitosis. Levels of the protein cell division cycle‐associated protein 3 (CDCA3), which is functionally required for mitotic entry, are regulated by APC/CCdh1. CDCA3 is an intrinsically disordered protein and contains both C‐terminal KEN box and D‐box recognition motifs, enabling binding to Cdh1. Our previous findings demonstrate that CDCA3 has a phosphorylation‐dependent non‐canonical ABBA‐like motif within the linker region bridging these two recognition motifs and is required for efficient binding to Cdh1. Here, we sought to identify and further characterize additional residues that participate within this ABBA‐like motif using detailed in vitro experiments and in silico modeling studies. We identified the role of H‐bonds, hydrophobic and ionic interactions across the CDCA3 ABBA‐like motif in the linker region between KEN and D‐box motifs. This linker region adopts a well‐defined structure when bound to Cdh1 in the presence of phosphorylation. Upon alanine mutation, the structure of this region is lost, leading to higher flexibility, and alteration in affinities due to binding to alternate sites on Cdh1. Our findings identify roles for the anchoring residues in the non‐canonical ABBA‐like motif to promote binding to the APC/CCdh1 and regulation of CDCA3 protein levels.
Genetic encoding of 3‐nitro‐tyrosine reveals the impacts of 14‐3‐3 nitration on client binding and dephosphorylation
Authors: Zhu Phillip , Nguyen Kyle T. , Estelle Aidan B. , Sluchanko Nikolai N. , Mehl Ryan A. , Cooley Richard B. 
Published: January 2023

Abstract14‐3‐3 proteins are central hub regulators of hundreds of phosphorylated “client” proteins. They are subject to over 60 post‐translational modifications (PTMs), yet little is known how these PTMs alter 14‐3‐3 function and its ability to regulate downstream signaling pathways. An often neglected, but well‐documented 14‐3‐3 PTM found under physiological and immune‐stimulatory conditions is the conversion of tyrosine to 3‐nitro‐tyrosine at several Tyr sites, two of which are located at sites considered important for 14‐3‐3 function: Y130 (β‐isoform numbering) is located in the primary phospho‐client peptide‐binding groove, while Y213 is found on a secondary binding site that engages with clients for full 14‐3‐3/client complex formation and client regulation. By genetically encoding 3‐nitro‐tyrosine, we sought to understand if nitration at Y130 and Y213 effectively modulated 14‐3‐3 structure, function, and client complexation. The 1.5 Å resolution crystal structure of 14‐3‐3 nitrated at Y130 showed the nitro group altered the conformation of key residues in the primary binding site, while functional studies confirmed client proteins failed to bind this variant of 14‐3‐3. But, in contrast to other client‐binding deficient variants, it did not localize to the nucleus. The 1.9 Å resolution structure of 14‐3‐3 nitrated at Y213 revealed unusual flexibility of its C‐terminal α‐helix resulting in domain swapping, suggesting additional structural plasticity though its relevance is not clear as this nitrated form retained its ability to bind clients. Collectively, our data suggest that nitration of 14‐3‐3 will alter downstream signaling systems, and if uncontrolled could result in global dysregulation of the 14‐3‐3 interactome.
Consistent methods for fat‐free mass, creatinine clearance, and glomerular filtration rate to describe renal function from neonates to adults
Authors: O'Hanlon Conor J. , Holford Nick , Sumpter Anita , Al‐Sallami Hesham S. 
Published: January 2023

AbstractQuantifying the effect of kidney disease on glomerular filtration rate (GFR) is important when describing variability in the clearance of drugs eliminated by the kidney. We aimed to develop a continuous model for renal function (RF) from prematurity to adulthood based on consistent models for fat‐free mass (FFM), creatinine production rate (CPR), and GFR. A model for fractional FFM in premature neonates to adults was developed using pooled data from 4462 subjects and 2847 FFM observations. It was found that girls have an FFM higher than that predicted from adult women based on height, total body mass, and sex, and boys have an FFM lower than adult men until around the onset of puberty, when it approaches adult male values. Data from 108 subjects with measurements of serum creatinine (Scr) and GFR were used to construct a model for CPR. Creatinine clearance was predicted using a model for CPR (based on FFM, postmenstrual age, and sex) and Scr that avoids discontinuous predictions between neonates, children, and adults. Individual CPR may then be used with individual Scr to predict the estimated GFR (eGFR; eGFR = CPR/Scr). A previously published model for human GFR based on 1153 GFR observations in 923 subjects without known kidney disease was updated using the model for fractional FFM to predict individual size and age‐consistent values for the expected normal GFR (nGFR). Individual renal function was then calculated using RF = eGFR/nGFR.
Al‐based Isoreticular Metal‐Organic Frameworks with MIL‐53 Topology as Effective Adsorbents in Methane Purification
Authors: Wamba Honore N. , Singh Narendra , Dalakoti Suman , Divekar Swapnil , Arya Aarti , Tagne Kuate Alain C. , Ngoune Jean , Dasgupta Soumen 
Published: January 2023

AbstractIn the present investigation, an isoreticular series of Al‐based metal‐organic frameworks (MOFs) with MIL‐53 topology namely, MIL‐53(Al)‐FA, MIL‐53(Al)‐BDC, MIL‐53(Al)‐NDC and MIL‐53(Al)‐BPDC formed by organic linkers with different molecular size and correlated porosity were examined for their adsorption capacity for C3H8, C3H6, C2H4, and CH4, and C3H8/CH4, C3H6/CH4, C2H4/CH4 separation selectivity. C3H8 and C3H6 adsorption is found to be sensitive to van der Waals forces and increases with increasing micropore volume of the MOFs. Ideal Adsorption Solution Theory (IAST) has been applied to estimate binary C3H8/CH4, C3H6/CH4 (C3/C1), and C2H4/CH4 (C2/C1) selectivity. The MOFs investigated have shown high C3/C1 selectivity with MIL‐53(Al)‐FA exhibiting exceptional C3H8/CH4 and C3H6/CH4 selectivity of 330 and 246, respectively, for the 5 : 95 (v/v) mixtures. MIL‐53(Al)‐FA also exhibited the highest C2/C1 selectivity among them. The high affinity of MIL‐53 Al‐based MOFs for C3 and C2 hydrocarbons over C1 make them suitable as adsorbents for methane purification.
Design and Fabrication of Anticancer Drug‐Loaded Poly(ϵ‐caprolactone)‐Poly(ethylene glycol)‐Poly(ϵ‐caprolactone) Micelles as Controlled Release System
Authors: Gökçe Kocabay Özlem , İsmail Osman 
Published: January 2023

AbstractIn this study, doxorubicin (DOX) loaded polymeric micelles (PMs) were synthesized based on biodegradable poly(ϵ‐caprolactone)‐poly(ethylene glycol)‐poly(ϵ‐caprolactone) (PCEC) triblock copolymers. So four parameters (shaking speed (rpm) X1, time of contact (hour) X2, amount of triethylamine (TEA) (μL) X3, DOX% X4) were optimized. Then by adding valspodar (PSC 833) or D‐α‐Tocopherol polyethylene glycol 1000 succinate (TPGS 1000) to the formulations DOX/PSC 833‐PMs or DOX/TPGS 1000‐PMs were prepared by a nanoprecipitation method. The synthesized micelles exhibited high drug‐loading encapsulation efficiency (>78.98 %), high stability, and pH‐dependent drug release. The results showed that the encapsulation efficiencies were not compromised by co‐encapsulation of two agents. Finally, it was observed that the association of both DOX and PSC 833 or both DOX and TPGS 1000 within a single micelle formulation elicited the most soluble DOX as compared to DOX loaded formulations (DOX‐PMs) while using a lower amount of polymer compared to separated micelle formulations.
An efficient caching security approach for content‐centric mobile networks in internet of things systems
Authors: Du Zhuang , Obaidat Mohammad S. , Wu Guowei , Hsiao Kuei‐Fang 
Published: January 2023

AbstractWith the expansion of internet of things (IoT), the IP‐based network architecture has been difficult to support the development of IoT. Content‐centric mobile networking (CCMN) models are based on naming the content to get rid of address‐space scarcity, caching the content at intermediate nodes to provide efficient data delivery, which can solve the development bottleneck of IoT. The in‐network caching is a key factor to enable practical deployments of CCMN. And it is also subject to serious security threats of cache pollution attacks (CPA), which can tamper the distribution of content and reduce the advantages of built‐in cache. In addition, the identity and trust mechanism of mobile devices are also important factors hindering the deployment of CCMN. However, existing caching security mechanisms cannot be applied directly, because the features of the built‐in cache, including ubiquity, mobility, and heterogeneity, bring new challenges on designing the caching security mechanism against CPA. In this article, we propose a lightweight CPA detection and defense approach for CCMN. We first model the attack and defense process of CPA as a dynamic game, which can optimize the performance of the attack detection. Then, we adopt popularity analysis to detect CPA, and accurately estimate the current network and attack state by a logical regression algorithm. Our design can also intelligently maintain the identity and trust mechanism. Finally, we design a punishment mechanism to deal with the attackers. Extensive simulations demonstrate that our approach can detect CPA efficiently, mitigate the impact of CPA effectively. Our game model can reduce the impact of locality‐disruption attack and false‐locality attack by 60% and 30%, respectively, compared with the state‐of‐the‐art methods. When the game reaches Nash equilibrium, our model can reduce the impact of CPA on cache hit ratio by 55% on average.
A review on the performance of oscillating heat pipe used in battery cooling
Authors: Suresh Kumar R. , Jayanthi N. , Sudhakar K. , Muralidharan K. , Jayaprabakar J. 
Published: January 2023

AbstractWhen comparing base paths for converting to renewable energy with conventional based routes, electric vehicles (EVs) offer the most efficient and affordable solution for the aforementioned problem. EVs use lithium‐ion batteries to store energy, but these batteries face an array of difficulties, includes poor performance at both high and low temperatures, high temperature electrode life reduction and thermal runaway safety worries. These issues have a direct impact based on performance, dependability, cost, and security of the vehicle. For Lithium‐ion (Li‐ion) battery packs used in Electric Drive Vehicles (EDVs), selecting the best cooling technique and developing an effective cooling control strategy are crucial for enhancing security, increasing the pack's validity, and decreasing expenses. The appropriate range of temperatures for such battery packs range between 15°C and 35°C. Trade‐offs must be regarded when deciding how to cool and creating strategies, including those involving prices, complexity, weight, cooling results, homogeneity of temperature, and parasitic power. The batteries may be fatally destroyed if they overheat due to chemical reactions triggered by the flow of electrons during the charging and discharging operation in hot temperatures. Therefore, numerous thermal management of batteries system types as well as potential for progress are explored in this evaluation study. The Battery Thermal Management Systems (BTMS) for electric vehicles has a lot of room for further research, it is concluded. Temperature regulation of lithium‐ion batteries is challenging due to the weak heat resistance of lithium ions. The internal working temperature significantly affects influence on the functionality and lifespan of lithium‐ion batteries. To guarantee a Li‐ion batteries reliable performance for a given application, battery cell thermal characterization is crucial. Due to the high heat that commonly used Lithium‐ion (Li‐ion) batteries produce during fast charging and discharging, Thermal Management Systems (TMS) are necessary for the operation of electric cars. In this paper, an experimentally verified OHP system is suggested as a module for cooling batteries.
Colorado pet owners’ perceptions of and attitudes towards antimicrobial drug use and resistance
Authors: Taylor Daniel D. , Scallan Walter Elaine J. 
Published: January 2023

AbstractBackgroundAntimicrobial drug (AMD) use in companion animal medicine may contribute to antimicrobial resistance (AMR) in both pets and humans. However, pet owners' attitudes and perceptions regarding AMD use and AMR have not been extensively studied in the United States.MethodsA cross‐sectional survey at five Colorado veterinary hospitals collected information about pet owners' knowledge and perceptions of AMD use and AMR, adherence with AMD treatment instructions and the role of the veterinarian in the AMD prescribing process.ResultsThe pet owners surveyed did not have an adequate understanding of AMR and were unaware of the potential human health impact of AMD use in pets. However, most pet owners reported adherence with veterinary prescription instructions and indicated that they trusted their veterinarian to make appropriate decisions for their pets.LimitationsThe cross‐sectional design focusing on Colorado pet owners limits the generalisability of the results. Selection and social desirability biases may have occurred, which could have affected who participated and how participants responded to statements.ConclusionsPet owners play an important role in the AMD prescription process, and their lack of AMR understanding should be addressed in antimicrobial stewardship plans. Further research on how to effectively incorporate pet owners into stewardship interventions is needed.