bluuebunny/crossref_metadata_2025_split huggingface dataset:
FLEKSIBILITAS TENAGA PENDIDIK TERHADAP PERGANTIAN KURIKULUM 2013 MENJADI KURIKULUM MERDEKA
Authors: Fadhila Alfia Zahro 
Published: July 2023

Indonesia adalah salah satu negara yang terdampak covid 19 sehingga dunia pendidikan ikut terdampak melalui PSBB dan pergantian kurikulum dari kuirkulum 2013 menjadi kurikulum merdeka. Pada tahapan kurikurum 2013 dan kurikulum merdeka di MTsN Ponorogo sudah melakukan tahapan kurikulum yang sangat baik mulai dari kurikulum mulai dari perencanaan hingga evaluasi dengan baik. Penelitian ini menggunakan metode kualitatif dan pengambilan data menggunakan observasi dan wawancara. Setelah data terkumpul di analisis dan di olah kemudian di tarik menjadi sebuah kesimpulan. Hasil penelitian menunjukkan bahwa terdapat tantangan mengenai fleksibilitas dan cara upgrade guru dalam melakukan pembelajaran berbasis kurikulum merdeka. Penelitian yang kami lakukan, bertujuan untuk tolak ukur dalam menjalankan kurikulum sehingga mengetahui bagaimana faktor keberlangsungan kurikulum hingga dampak yang terjadi pada perencanaan, pelaksanaan dan evaluasi yang dilakukan oleh tenaga guru di MTsN Ponorogo.
PENGABDIAN MASYARAKAT SOCIAL EDUCATION ‘’ANTI BULLYING’’ DI SMA HASANUDIN
Authors: Fatmawati Rosa Nur , Jati Ibnu Eka Nugroho , Widyaningrum Diyah Ayu , Mukarom Mukarom 
Published: July 2023

Bullying is behavior that intentionally wants to dominate, hurt, or get rid of the victim, either directly (physically) or indirectly (verbally). The impact of bullying can cause psychological pressure and if left untreated will worsen the victim to commit suicide. This study aims to determine the most appropriate types of interventions that can be implemented to reduce bullying and prevent suicide risk using a systematic review based on PRISMA guidelines.
The studies were searched across five databases: Scopus, ScienceDirect, Proquest, Pubmed and CINHL and must have been published from 2014-2019. Articles are identified using the keywords "bullying" AND "intervention", "anti-bullying program". 14 articles were found to be used using this systematic review. The article reviewed stated that the anti-bullying program involving several parties has the benefit of reducing intimidation. Several intervention efforts can be used to prevent the recurrence of violations and can also be used as promotive and preventive by carrying out anti-bullying counseling at the Hasanudin Vocational School, Wajak Village, Wajak District, Malang Regency.
Comparison of biomechanical parameters of two Chinese cervical spine rotation manipulations based on motion capture and finite element analysis
Authors: Lin Dongxin , He Zaopeng , Weng Rui , Zhu Yuhua , Lin Zhiwei , Deng Yuping , Yang Yang , Tan Jinchuan , Wang Mian , Li Yanbin , Huang Gang , Yu Guanghao , Cai Daozhang , Huang Xuecheng , Huang Wenhua 
Published: July 2023

Objective: The purpose of this study was to obtain the stress-strain of the cervical spine structure during the simulated manipulation of the oblique pulling manipulation and the cervical rotation-traction manipulation in order to compare the mechanical mechanism of the two manipulations.Methods: A motion capture system was used to record the key kinematic parameters of operating the two manipulations. At the same time, a three-dimensional finite element model of the C0-T1 full healthy cervical spine was established, and the key kinematic parameters were loaded onto the finite element model in steps to analyze and simulate the detailed process of the operation of the two manipulations.Results: A detailed finite element model of the whole cervical spine including spinal nerve roots was established, and the validity of this 3D finite element model was verified. During the stepwise simulation of the two cervical spine rotation manipulations to the right, the disc (including the annulus fibrosus and nucleus pulposus) and facet joints stresses and displacements were greater in the oblique pulling manipulation group than in the cervical rotation-traction manipulation group, while the spinal cord and nerve root stresses were greater in the cervical rotation-traction manipulation group than in the oblique pulling manipulation group. The spinal cord and nerve root stresses in the cervical rotation-traction manipulation group were mainly concentrated in the C4/5 and C5/6 segments.Conclusion: The oblique pulling manipulation may be more appropriate for the treatment of cervical spondylotic radiculopathy, while cervical rotation-traction manipulation is more appropriate for the treatment of cervical spondylosis of cervical type. Clinicians should select cervical rotation manipulations for different types of cervical spondylosis according to the patient’s symptoms and needs.
Leishmania infection alters macrophage and dendritic cell migration in a three-dimensional environment
Authors: Luz Yasmin , Rebouças Amanda , Bernardes Carla Polyana O. S. , Rossi Erik A. , Machado Taíse S. , Souza Bruno S. F. , Brodskyn Claudia Ida , Veras Patricia S. T. , dos Santos Washington L. C. , de Menezes Juliana P. B. 
Published: July 2023

Background: Leishmaniasis results in a wide spectrum of clinical manifestations, ranging from skin lesions at the site of infection to disseminated lesions in internal organs, such as the spleen and liver. While the ability of Leishmania-infected host cells to migrate may be important to lesion distribution and parasite dissemination, the underlying mechanisms and the accompanying role of host cells remain poorly understood. Previously published work has shown that Leishmania infection inhibits macrophage migration in a 2-dimensional (2D) environment by altering actin dynamics and impairing the expression of proteins involved in plasma membrane-extracellular matrix interactions. Although it was shown that L. infantum induces the 2D migration of dendritic cells, in vivo cell migration primarily occurs in 3-dimensional (3D) environments. The present study aimed to investigate the migration of macrophages and dendritic cells infected by Leishmania using a 3-dimensional environment, as well as shed light on the mechanisms involved in this process.Methods: Following the infection of murine bone marrow-derived macrophages (BMDM), human macrophages and human dendritic cells by L. amazonensis, L. braziliensis, or L. infantum, cellular migration, the formation of adhesion complexes and actin polymerization were evaluated.Results: Our results indicate that Leishmania infection inhibited 3D migration in both BMDM and human macrophages. Reduced expression of proteins involved in adhesion complex formation and alterations in actin dynamics were also observed in Leishmania-infected macrophages. By contrast, increased human dendritic cell migration in a 3D environment was found to be associated with enhanced adhesion complex formation and increased actin dynamics.Conclusion: Taken together, our results show that Leishmania infection inhibits macrophage 3D migration, while enhancing dendritic 3D migration by altering actin dynamics and the expression of proteins involved in plasma membrane extracellular matrix interactions, suggesting a potential association between dendritic cells and disease visceralization.
The evolution of spatiotemporal patterns and influencing factors of high-level tourist attractions in the Yellow River Basin
Authors: Shu Rentian , Xiao Jingyi , Yang Yanxia , Kong Xiangdan 
Published: July 2023

Introduction: High-level tourist attractions (HLTAs) are essential components of high-quality tourism development in the Yellow River Basin. In the context of holistic tourism and mass tourism, it is necessary to re-examine the spatial pattern of HLTAs.Methods: Selecting the Qing–Gan–Ning region of the Yellow River Basin as a case study site, based on the data on 590 high-level tourist attractions in 2009, 2015, and 2021, and with the help of ArcGIS10.8 spatial analysis tools, the nearest neighbor index, kernel density analysis, and standard deviation ellipse methods, such as ellipse and ESDA spatial exploratory analysis, were used to analyze the spatiotemporal pattern of the spatial distribution of high-level tourist attractions in the study area from the aspects of type, density, and spatial autocorrelation. Overlay analysis, buffer analysis, and other methods were used to select the influencing factors, and finally, the influencing factors were verified with the help of GeoDetector.Conclusions: The conclusions are as follows: the NNI values for the Qing–Gan–Ning area of the Yellow River Basin are 0.699, 0.7, and 0.618, and the spatial structure type was clustered. The distribution density showed an evolutionary trend of point-like agglomeration and linear expansion, with the provincial capital as the core and the Yellow River as the axis. The distribution density of high-level tourist attractions is 27, 44, and 74 per 10,000 km2. In terms of the dynamic distribution direction of the center of mass, there was little interannual variation, showing a northeast–southwest direction, which is consistent with the flow direction of the Yellow River in the region. Furthermore, the analysis of Moran’s I index showed clear spatial autocorrelation at the county scale. HLTAs exhibited clustering and wider distribution in H–H and L–L zones, while the L–H and H–L zones displayed a more dispersed and narrower distribution. The order of factors affecting the spatial distribution of HLTAs was economic factors (0.5257) &gt; social factors (0.5235) &gt; natural factors (0.491), and interactive detection showed that there were two-factor enhancements and nonlinear enhancements in the factors.Dicussions: This study contributes to the conservation development and sustainable development of ecotourism resources in the Yellow River Basin.
Association between the triglyceride to high-density lipoprotein cholesterol ratio and the risk of gestational diabetes mellitus: a second analysis based on data from a prospective cohort study
Authors: You Yun , Hu Haofei , Cao Changchun , Han Yong , Tang Jie , Zhao Weihua 
Published: July 2023

BackgroundAlthough there is strong evidence linking triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio to insulin resistance and diabetes mellitus, its clinical importance in pregnant women has not been well determined. This study sought to determine the connection between the TG/HDL-C ratio in the first trimester and the eventual onset of gestational diabetes mellitus (GDM).MethodsWe performed a secondary analysis of open-access data from a prospective cohort study. This present study included 590 singleton pregnant women at 10-14 weeks who visited the outpatient clinics for prenatal checks and were recorded at Incheon Seoul Women’s Hospital and Seoul Metropolitan Government Seoul National University Boramae Medical Center in Korea. A binary logistic regression model, a series of sensitivity analyses, and subgroup analysis were used to examine the relationship between TG/HDL-C ratio and incident GDM. A receiver operating characteristic (ROC) analysis was also conducted to assess the ability of the TG/HDL-C ratio to predict GDM.ResultsThe mean age of the included individuals was 32.06 ± 3.80 years old. The mean TG/HDL-C ratio was 1.96 ± 1.09. The incidence rate of GDM was 6.27%. After adjustment for potentially confounding variables, TG/HDL-C ratio was positively associated with incident GDM (OR=1.77, 95%CI: 1.32-2.38, P=0.0001). Sensitivity analyses and subgroup analysis demonstrated the validity of the relationship between the TG/HDL-C ratio and GDM. The TG/HDL-C ratio was a good predictor of GDM, with an area under the ROC curve of 0.7863 (95% CI: 0.7090-0.8637). The optimal TG/HDL-C ratio cut-off value for detecting GDM was 2.2684, with a sensitivity of 72.97% and specificity of 75.05%.ConclusionOur results demonstrate that the elevated TG/HDL-C ratio is related to incident GDM. The TG/HDL-C ratio at 10-14 weeks could help identify pregnant women at risk for GDM and may make it possible for them to receive early and effective treatment to improve their prognosis.
Relationships between intra-pancreatic fat deposition and lifestyle factors: a cross-sectional study
Authors: Mitsushio Kento , Baden Megu Y. , Kato Sarasa , Niki Akiko , Ozawa Harutoshi , Motoda Saori , Ishibashi Chisaki , Hosokawa Yoshiya , Fujita Yukari , Tokunaga Ayumi , Nammo Takao , Kozawa Junji , Shimomura Iichiro 
Published: July 2023

AimsThe excess deposition of intra-pancreatic fat deposition (IPFD) has been reported to be associated with type 2 diabetes, chronic pancreatitis, and pancreatic ductal adenocarcinoma. In the current study, we aimed to identify a relationship between lifestyle factors and IPFD.Materials and methods99 patients admitted to the Osaka University Hospital who had undergone abdominal computed tomography were selected. We evaluated the mean computed tomography values of the pancreas and spleen and then calculated IPFD score. Multiple regression analyses were used to assess the associations between IPFD score and lifestyle factors.ResultsFast eating speed, late-night eating, and early morning awakening were significantly associated with a high IPFD score after adjusting for age, sex, diabetes status and Body Mass Index (p=0.04, 0.01, 0.01, respectively).ConclusionThe current study has elucidated the significant associations of fast eating speed, late-night eating, and early morning awakening with IPFD.
Effect of near-surface winds on the measurement of forest soil CO2 fluxes using closed air chambers
Authors: Jiang Junjie , Hu Junguo , Xu Xiaojun , Li Yongfu , Sheng Jie 
Published: July 2023

Forest soil CO2 flux measurements are important for studying global climate change. Current monitoring methods are based on closed gas chambers, which block the wind pumping effect of near-surface winds in the measurements, resulting in biased values. Therefore, in this study, the effects of near-surface winds on chamber-monitored fluxes were investigated. The CO2 flux was quantified using a designed flux reference system with different CO2 concentrations, and the monitoring performance of the closed chamber was studied. Wavelet coherence was used to analyze the response relationship between near-surface winds and soil gas, and was combined with a flux calculation model to explore the relevant factors influencing gas chamber measurement-produced bias. The data indicate that at near-surface wind speeds greater than 0.8 m·s−1, gas transport enhancement was significant and further increased the deviation of the gas chamber-monitored CO2 fluxes. The monitoring error of the flow chamber (NSF) increased from 7% to 30% in soils with low carbon content, but did not vary significantly (3–7%) in soils with high CO2 concentrations. The flux measurement bias of the non-flow chamber (NSNF) was positively correlated with the soil carbon content, with the measurement error expanding by 16–24% with increasing soil CO2 concentrations. The measurement errors of the exponential and linear models in a windless environment were 9.8% (Exp) and 18.7% (Lin), respectively. The estimation errors of both models were positively correlated with both the time of a single monitoring event and the wind-induced coefficient Dw. Therefore, flux calculation models should be improved by considering environments with wind disturbances to reduce the effect of wind on measured values, which will help improve the accuracy of ecosystem carbon budgets.
Identification of stromal cell proportion-related genes in the breast cancer tumor microenvironment using CorDelSFS feature selection: implications for tumor progression and prognosis
Authors: Guo Sicheng , Ma Yuting , Li Xiaokang , Li Wei , He Xiaogang , Yuan Zheming , Hu Yuan 
Published: July 2023

Background: The tumor microenvironment (TME) of breast cancer (BRCA) is a complex and dynamic micro-ecosystem that influences BRCA occurrence, progression, and prognosis through its cellular and molecular components. However, as the tumor progresses, the dynamic changes of stromal and immune cells in TME become unclear.Objective: The aim of this study was to identify differentially co-expressed genes (DCGs) associated with the proportion of stromal cells in TME of BRCA, to explore the patterns of cell proportion changes, and ultimately, their impact on prognosis.Methods: A new heuristic feature selection strategy (CorDelSFS) was combined with differential co-expression analysis to identify TME-key DCGs. The expression pattern and co-expression network of TME-key DCGs were analyzed across different TMEs. A prognostic model was constructed using six TME-key DCGs, and the correlation between the risk score and the proportion of stromal cells and immune cells in TME was evaluated.Results: TME-key DCGs mimicked the dynamic trend of BRCA TME and formed cell type-specific subnetworks. The IG gene-related subnetwork, plasmablast-specific expression, played a vital role in the BRCA TME through its adaptive immune function and tumor progression inhibition. The prognostic model showed that the risk score was significantly correlated with the proportion of stromal cells and immune cells in TME, and low-risk patients had stronger adaptive immune function. IGKV1D-39 was identified as a novel BRCA prognostic marker specifically expressed in plasmablasts and involved in adaptive immune responses.Conclusions: This study explores the role of proportionate-related genes in the tumor microenvironment using a machine learning approach and provides new insights for discovering the key biological processes in tumor progression and clinical prognosis.
In utero position matters for littermate cell transfer in mice: an additional and confounding source with maternal microchimerism
Authors: Giassi Mathilde , Hemon Marie F. , Martin Marielle , Roudier Jean , Auger Isabelle , Lambert Nathalie C. 
Published: July 2023

IntroductionFeto-maternal cell transfer during pregnancy is called microchimerism (Mc). Its persistence in respective hosts is increasingly studied as to its potential role in immune tolerance, autoimmunity, cancer, and degenerative diseases. Murine models with transgenic reporter genes, heterozygously carried by the mother, allow maternal Mc tracking in wild-type (WT) offspring. However, as gestation in mice is multi-embryonic, an exchange of cells between fetuses carrying the same reporter gene as their mother and negative WT littermate, named littermate Mc (LMc), can occur and be confounded with the maternal source. We propose here to evaluate LMc contribution in mice.MethodsTo avoid the maternal confounding source of Mc, transgenic males, heterozygous for a reporter gene, here, the human leukocyte antigen DRB1*04 (DR4+/−), were crossed with WT females (DR4−/−). DR4+/− LMc was specifically quantified by HLA-DR4 quantitative PCR, i) in utero in main organs from 15 DR4−/− fetuses from three litters of 11, nine, and five; and ii) after birth in two litters of eight pups: in two DR4−/− stillborns and four DR4−/− adult mice.ResultsAt embryonic stages, DR4−/− fetuses having one or two nearby DR4+/− littermates in the same uterine horn were almost seven times more frequently positive for DR4− microchimerism in their organs (p = 0.01) and had quantitatively more LMc (p = 0.009) than those without nearby DR4+/− littermates. Furthermore, LMc persists at birth and into adulthood with interindividual heterogeneity.ConclusionsThis study identifies heterogeneity for LMc acquisition according to in utero position and different interpretation of previously published results on maternal Mc in mice.
Different vertical heat transport induced by submesoscale motions in the shelf and open sea of the northwestern South China Sea
Authors: Pan Hao , Qiu Chunhua , Liang Hong , Zou Liwei , Zhang Ziqi , He Benjun 
Published: July 2023

Submesoscale currents are known to be associated with strong vertical velocities (O (10) m/day), regulating the redistributions of energy and matter balances. The northern South China Sea (SCS) is fulfilled with submesoscale motions, which might induce strong vertical heat transport (VHT). We set up a 1-km horizontal resolution Massachusetts Institute of Technology General Circulation Model (MITgcm) to study the seasonal variations in submesoscale vertical heat transport in shelf regions and open seas. Spectrum analysis shows that the spatial scale separating submesoscale and mesoscale motions are 14 and 30 km for the shelf and open regions, respectively. The submesoscale VHT in the shelf region is one order of magnitude larger than that in the open ocean. The former has the largest value in summer and winter, which might be induced by summer upwelling and winter downwelling, while the latter is strongest in winter and weakest in summer in open regions. The submesoscale VHT also appears to have intra-seasonal variations and might be attributed to the disturbances of tropical cyclones and life stages of submesoscale eddies. The submesoscale VHT is strongest in the pregeneration phase of the eddies, and the maximum VHT belt has an entrainment type at the developing and mature stages. The chlorophyll-a concentration also has the same temporal variation as the different life-stage of eddies. This study provides local VHT induced by submesoscale motions, which is expected to improve our understanding of submesoscale air–sea interactions and their biological effects.
Absolute configuration assignment of marine natural products in Brazil
Authors: Batista Andrea N. L. , dos Santos Fernando M. , Valverde Alessandra L. 
Published: July 2023

Brazil is one of the most biodiverse countries in the world, with a coastline that stretches over 7,000 km including various marine ecosystems, such as coral reefs, mangroves, and seagrass beds, among other habitats. These diverse environments provide a rich source of compounds, derived from primary or secondary metabolism, which may have countless biological activities. Research on marine natural products (MNP) in Brazil has been ongoing for several decades and led to the discovery of numerous bioactive compounds with potential applications in medicine, agriculture, and cosmetics. These MNP are structurally complex, both from an architectural and stereochemical point of view. However, even with all the well-established techniques for the absolute configuration (AC) assignment, this stage of structural characterization of natural products is still under-explored and remains a challenge. This review presents an overview of natural product chemistry in Brazil, focusing on the stereochemical assignment of marine chiral compounds. The main goals are to describe the techniques employed in the assignments as well as to highlight the importance of choosing the appropriate methods for chiral natural products AC determinations.