bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association Between Chronic Fatigue Syndrome/Myalgic Encephalomyelitis and Cardiovascular Disease
Authors: Denu Mawulorm KI , Revoori Ritika , Eghan Cherita , Kwapong Fredrick Larbi , Hillman Andrew , Normeshie Cornelius A , Berko Kofi Poku , Aidoo Emily L. , Buadu Maame Araba E 
Published: September 2023

Abstract

Background: Chronic Fatigue Syndrome or Myalgic Encephalomyelitis (CFS/ME) is a medical condition characterized by severe and prolonged fatigue that is not relieved by rest or attributed to any underlying medical or psychological condition. Individuals with CFS/ME are considered to have an increased risk of a wide range of comorbid conditions, including cardiovascular disease (CVD). The association between CFS/ME and CVD is not fully understood.
Objective: To determine the prevalence of CFS/ME in a sample population and examine its association with CVD.
Methods: Data was analyzed from the 2021 National Health Interview Survey (NHIS). Information on sociodemographic factors, CVD risk factors, and history of CFS/ME and CVD were collected. Multivariate logistic regression model was used to determine the association between CFS/ME and CVD, adjusting for traditional CVD risk factors (age, sex, race, hypertension, diabetes, dyslipidemia, smoking, and body mass index (BMI).
Results: Median age of participants was 53 years, and majority of participants were female (53.9%). Prevalence of CFS/ME was 1.4%. A history of CFS/ME was significantly associated with CVD (aOR: 3.13, 95%CI: 2.37, 4.15, p-value: <0.001) after adjusting for traditional CVD risk factors.
Conclusion: A history of CFS/ME was independently associated with CVD after adjusting for traditional CVD risk factors. Patients with CFS/ME need close evaluation for CVD. Further studies are needed to better understand the relationship between CFS/ME and CVD.
A comparative study of cement-augmented pedicle screw fixation combined with vertebroplasty and PKP alone in the treatment of osteoporotic vertebral burst fracture
Authors: Zheng Jianqing , Wu Yue , Guo Chunliang , Zhang Qin , Xue Yuntao , Ding Tao 
Published: September 2023

Abstract

To compare the clinical efficacy of cement-augmented pedicle screw fixation combined with vertebroplasty (PS-VP) and PKP alone in the treatment of osteoporotic vertebral burst fracture (OVBF), The clinical data of 41 OVBF patients admitted to our department from January 2017 to December 2022 were retrospectively analyzed, including 18 patients who underwent PS-VP and 23 patients who underwent PKP alone. The age, BMI, LSS, NRS, ODI, KA and AHR were compared between the two groups to assess the efficacy of the two procedures. The differences between the postoperative clinical indicators of the two procedures were statistically significant compared with the preoperative ones (P＜0.05). The NRS, ODI, KA and AHR showed great difference between the two groups at 6 months postoperatively(P＜0.05). The KA and AHR in the PS-VP group at 6 months postoperatively were close to those at 3 days (P＞0.05), whereas the KA in the PKP alone group at 6 months postoperatively was larger and AHR was lower than that at 3 days postoperatively with statistical significance (P＜0.05). To conclude, there is no significant difference in the near-term efficacy between PS-VP and PKP alone for OVBF, but the former has advantages in improving clinical symptoms and dysfunction, restoring height of the injured vertebra and maintaining spinal loading capacity in the medium and long term.
Effect of temperature on the growth, reproduction, and germination pattern of two populations of Chloris virgata
Authors: Desai Het , Chauhan Bhagirath Singh 
Published: September 2023

Abstract

A holistic knowledge about the growth of weed species (i.e., from germination to seed production) in response to environmental factors (e.g., temperature, sunlight, moisture, etc.) is of utmost importance to understand the intensity of infestation, especially for Chloris virgata which demonstrates year-round germinability. An experiment in naturally lit greenhouse was conducted to assess the vegetative and reproductive growth of two C. virgata populations [FTR3 (glyphosate-susceptible, GS) and FTR11 (glyphosate-resistant, GR)] at two alternating temperature regimes: 25/15°C, low temperature and 35/25°C, high temperature. The average seed production of both populations was about 78% higher (12635 seeds/plants) at 25/15°C than at 35/25°C (7117 seeds/plants), indicating that late-winter/early-summer maturing cohorts will produce more seeds compared to the cohorts that mature in mid/late summer. The germination pattern of FTR3 and FTR11 maturing at two alternating temperature regimes (25/15°C and 35/25°C) was evaluated in an incubator calibrated to deliver 30/20°C with a 12 h/ 12 h photoperiod. The seeds collected from FTR3 and FTR11, which completed the lifecycle at 35/25°C, released dormancy faster than those matured at 25/15°C, suggesting the late-winter maturing flushes will have an extended germination period. In the light of climate change, these results could aid in designing sustainable integrated management programs to effectively manage this weed species in Australian farming systems.
Total Synthesis of Tetracyclic Spirooxindole Alkaloids via a Double Oxidative Rearrangement/Cyclization Cascade
Authors: Qi Xiangbing , Wang Xin , Zhang Mengjiao , liu Xiaolei , Lou Mingliang , Li gen 
Published: September 2023

Abstract
Piperidine and pyridine are the most significant structural components of bioactive molecules. Aza-Achmatowicz rearrangement is a broadly appliable approach to access piperidine or pyridine derivatives owing to the easily adjustable electronic properties of the amino group. When combined with other chemical transformations, such as nucleophilic cyclization or cycloaddition, it provides entries to a variety of polycyclic skeletons present in naturally-derived alkaloids. Herein, we developed a one-pot reaction cascade of double oxidative rearrangement of furan and indole followed by a nucleophilic cyclization that was successfully applied for the formal synthesis of rhynchophylline/isorhynchophylline and the first total synthesis of 7(R)-geissoschizol oxindole/7(S)-geissoschizol oxindole. The reaction cascade has a broad substrate scope, with a variety of substitutions on the indoles and furans. Other innovative features include the chemo-selective dearomatization of the pyridinium moiety to form the C(sp3)-enriched, three-dimensional spiro[indolizidine-1,3´-oxindole] skeleton and a late-stage, regio- and stereoselective carbene insertion into a C(sp3)-H bond that enabled the successful installation of the adjacent carbon functionality for rhynchophylline and isorhynchophylline. In addition, 7(R)-geissoschizol oxindole/7(S)-geissoschizol oxindole were revised to their C-3 epimers and the mechanism for the reversed stereochemistry through the retro-Mannich/Mannich cascade was proposed and supported by the DFT calculations.
Analysis of the top-down and bottom-up controls on the zooplankton of eutrophic freshwater Yeniçağa Lake (Turkey)
Authors: Sorguç Bura Uğur , Demirkalp Fatma Yıldız , Saygı Yasemin 
Published: September 2023

Abstract
The objective of this study is to determine the relationship between zooplankton biomass and the factors that affect it and to assess the trophic status in Yeniçağa Lake, Turkey. For this purpose, chlorophyll-a values were used as the bottom-up effect, while planktivorous fish CPUE was used as the top-down effect. Additionally, to understand which nutrient has a stronger impact on chlorophyll-a, total nitrogen, and total phosphorus values were determined. Structural Equation Modeling was used to examine the bottom-up and top-down relationships, and it was understood that Cladocera, Calanoida, and Rotifera groups were negatively controlled by bottom-up effects, while Calanoida is negatively controlled and Cyclopoida and Rotifera are positively controlled by top-down effects. Moreover, it was understood that chlorophyll-a is influenced by both total nitrogen and total phosphorus, with a higher impact of total nitrogen. To determine the trophic status, chlorophyll-a, total phosphorus, Secchi depth, and Carlson TSI Indices obtained from these values were used. According to the findings from these values, the lake can be considered to be at the eutrophic level with a hypertrophic tendency.
Dosimetric study of line scanning for prostate cancer in comparison with passive scattering and volumetric modulated arc therapy
Authors: Takagi Masaru , Hasegawa Yasuhiro , Tateoka Kunihiko , Takada Yu , Hareyama Masato 
Published: September 2023

Abstract
Purpose
We performed a planning study to compare the dose distribution of the line scanning (LS) method with that of passive scattering (PS) method and volumetric modulated arc therapy (VMAT) for patients with localized prostate cancer.
Methods
Thirty patients treated in 2017–2019 were randomly selected. The dose constraints were the clinical target volume (CTV) D98 ≥ 73.0 Gy (RBE), rectal wall V65 < 17% and V40 < 35%, and bladder wall V65 < 25% and V40 < 50%. The CTV doses and rectal and bladder wall dose volumes were calculated and evaluated using the Freidman test. P < 0.05 was determined to be statistically significant.
Results
In all patients, the LS technique satisfied the dose restrictions for the CTV, rectal wall, and bladder wall. Ten (33.3%) and 21 (70.0%) patients using the PS method and five (16.7%) and one (3.3%) patients using the VMAT, respectively, failed to meet the requirements for the rectal and bladder walls. Wide ranges of the rectal and bladder wall volumes of V10–V70 were lower with LS than with PS and VMAT. LS was superior to VMAT in all dose-volume rectal and bladder wall indexes. PS outperformed the other two methods at Dmax.
Conclusion
Compared with PS and VMAT, the LS method enables further reduction of the rectal and bladder doses while maintaining the CTV dose. Our results suggest that proton therapy for patients with localized prostate cancer could lower gastrointestinal and genitourinary toxicities by changing from PS to LS.
Exploring the interplay of phytohormones and polyamines in drought-stressed Cress (Lepidium sativum) leaves
Authors: Alsharafa Khalid 
Published: September 2023

Abstract

The study investigated prolonged drought stress effects on phytohormone and polyamine levels in cress leaves, elucidating plant responses to harsh environments. The study found that various phytohormones, including 12-oxophytodienoic acid (OPDA), Jasmonic acid (JA), Jasmonyl-Isoleucine (JA-Ile), Abscisic acid (ABA), and salicylic acid (SA), increased during drought stress. ABA rose progressively. Similarly, indole-3-acetic acid (IAA) responded similarly to ABA and SA. Cytokinins, zeatin (ZT) and isopentenyl adenine (iP), played diverse roles in cress leaves' drought tolerance. ZT declined, while iP remained stable. Gibberellic acid (GA3) levels fell, but brassinolide (BL) increased significantly with drought. The study also explored drought stress's impact on polyamines, which decreased, revealing their sensitivity to severe drought. The research highlighted the complex regulatory mechanisms governing plant adaptation to water scarcity. The interplay between phytohormones (OPDA, JA, JA-Ile, ABA, SA, auxin, cytokinins, GA3, and BL) and polyamines contributes to plants ability to withstand drought stress and maintain physiological balance under adverse conditions. These findings provide insights into cress leaves dynamic response to drought and enhance our understanding of drought tolerance mechanisms in plants.
Impact of ohmic heating and ultrasound pretreatments on oil absorption and other quality parameters of fried potato
Authors: Sari Ferda , Incedayi Bige , Erol Nihal Turkmen , Akpinar Pınar , Copur O.Utku 
Published: September 2023

Abstract
In this study, the effect of pretreatments ((hot water blanching (HWB), ultrasound (US) and ohmic heating (OH)) on reducing the oil absorption of potato during frying and the changes in the quality parameters of the product ((total polyphenol (TP), in vitro digestion, total flavonoid (TF), antioxidant capacity (AC), chlorogenic acid (CA), textural and sensorial properties)) were investigated. The pretreatments applied significantly affected oil absorption and quality parameters of fried potato. The oil content of fried potatoes ranged from 26.06% to 32.01% depending on the pretreatment. OH pretreated potato had the highest content of TP (41.27 mg GAE/100g DM), TF (32.89 mg RE/100g DM) and CA (1.72 mg/100g DM). However, there was no significant difference between the pretreatments in terms of bioaccessibility of polyphenols at the end of digestion. Also, AC value of fried potato pretreated by OH (124.13 mmol AAE/100g DM) was higher compared to that of fresh potato (83.91 mmol AAE/100g DM), but other two pretreatments caused a decrease in AC. The highest hardness was observed in HWB treated potato strips. OH treated potato had the best color parameters. Sensory data indicated that US pretreated potato had the highest sensory scores followed by OH and HWB pretreated ones, respectively. Consequently, based on the above comprehensive quality evaluation, it can be suggested that OH pretreatment is a better choice for preparing deep fried potato.
Plasmonic Characterization of 3D Printing Metal-Polymer Nanocomposites
Authors: Mata María de la , de León Alberto Sanz , Valencia-Liñán Luisa , Molina Sergio 
Published: September 2023

Abstract
Plasmonic polymer nanocomposites (i.e., polymer matrices containing plasmonic nanostructures) are appealing candidates for the development of manifold technological devices relying on light-matter interactions, provided their inherent properties and processing capabilities. The smart development of plasmonic nanocomposites requires from in-depth optical analyses proving the material performance, along with correlative studies guiding the synthesis of tailored materials. Importantly, plasmon resonances emerging from metal nanoparticles affect the macroscopic optical response of the nanocomposite, leading to far- and near-field perturbations useful to address the optical activity of the material. We analyze the plasmonic behavior of two nanocomposites suitable for 3D printing, based on acrylic resin matrices loaded with Au or Ag nanoparticles. We compare experimental and computed UV-Vis macroscopic spectra (far-field) with single particle EELS analyses (near-field). We have extended the calculations of Au and Ag plasmon related resonances over different environments and nanoparticle sizes. Discrepancies between UV-Vis and EELS are dependent on the interplay between the metal considered, the surrounding media and the size of the nanoparticles. The study allows comparing in detail the plasmonic performance of Au- and Ag- polymer nanocomposites, whose plasmonic response is better addressed accounting for their intended applications (i.e., whether they rely on far- or near- field interactions).
Safety and Efficacy of 3% Hypertonic Saline Bolus Via Peripheral Intravenous Catheter for Neurological Emergencies
Authors: Khasiyev Farid , Hakoun Abdullah , Christopher Kara , Braun James , Wang Fajun 
Published: September 2023

Abstract
Background:
Elevated intracranial pressure (ICP) is a neurological emergency in patients suffering from acute brain injuries. Such a state requires immediate and effective interventions to prevent potential neurological deterioration. Current clinical guidelines recommend hypertonic saline (HTS) and mannitol as first-line therapeutic agents. Notably, HTS is conventionally administered through central venous catheters (CVC), which may introduce delays in treatment due to the complexities associated with CVC placement. These delays can critically affect patient outcomes, necessitating the exploration of more rapid therapeutic avenues. This study aimed to investigate the safety and efficacy of administering rapid boluses of 3% HTS via peripheral intravenous (PIV) catheters.
Methods:
A retrospective cohort study was performed on patients admitted to SSM Health Saint Louis University Hospital from March 2019 to September 2022 who received at least one 3% HTS bolus via PIV at a rate of 999 mL/hour for neurological emergencies. Outcomes assessed included complications related to 3% HTS bolus and its therapeutic effects as determined by changes in ICP, sodium, chloride, and serum osmolality.
Results:
Out of 216 3% HTS boluses administered in 124 patients, complications occurred in 8 administrations (3.7%). Pain at injection site (4 administrations; 1.9%) and thrombophlebitis (3 administrations; 1.4%) were most common. The median ICP reduced by 4.6 mmHg after 3% HTS bolus, with significant increases in serum sodium, chloride and osmolality (all p < 0.001).
Conclusions:
Rapid bolus of 3% HTS via PIV presents itself as a relatively safe and efficacious approach, with a compellingly low rate of complications. Its implementation could provide an invaluable alternative to the traditional CVC-based administration, potentially minimizing CVC-associated complications and expediting life-saving interventions for patients with neurological emergencies.
Impact and Post-Impact Damage Response of Interlayer Nonwoven Reinforced Hybrid Composites
Authors: Tiyek Tebernuş , Kaya Gaye 
Published: September 2023

Abstract
This study aims to increase the ductility and the damage tolerance capability of composite structures with interlayer nonwoven reinforcement. The novelty of this study stems from its innovative approach: a comprehensive examination of the arrangement of warp and weft fibres, as well as the preform layer, coupled with both intra-layer and inter-layer hybridization, all while accounting for the incorporation of nonwoven reinforcement. The flexural, compressive, impact and post-impact compressive strengths of unreinforced and interlayer nonwoven reinforced glass/carbon/epoxy hybrid composites are carefully investigated and compared. The nonwoven reinforcement led to a reduction in flexural strength and modulus for composite structures, while enhancing their strain, thus imparting greater ductility to the structure. Both hybridization and interlayer nonwoven reinforcement increased the peak forces of composites while reducing deformations. The cracks occurring in the composite structure under load were arrested by the barrier created by the nonwoven surfaces used between the layers, which was considered an enhancement in the damage tolerance of composite structures.
Virtual screening to investigate the potential targets and mechanisms of action of "Astragalus-Ligustrum" drug pair in the treatment of non-small cell lung cancer
Authors: Deng Zhengting , Tian Hu , Ding Yuanhua , Jin Qiming , Liu Yichen , Liu Tao , Zhao Tong 
Published: September 2023

Abstract
Astragalus membranaceus and Ligustrum lucidum are the common main components in Chinese patent medicine preparations which have been widely used in combination chemotherapy for tumor treatment. However, the specific mechanism of their anti-cancer effect has not been fully elucidated, and the traditional monomer research mode can hardly reflect the feature of Chinese medicine in treating diseases. In this study, virtual screening was used to explore the mechanism of “Astragalus-Ligustrum” drug pair in the treatment of non-small cell lung cancer (NSCLC). 28 active ingredients and 180 active ingredient targets were screened out from the drug pair by network pharmacology. Among them, 10 components, including quercetin and kaempferol, are the main active ingredients in the drug pair, whose mechanism of anti-NSCLC is to modulate the pathways of PI3K-Akt, PD-1/PD-L1, and T-cell receptor, and by affecting the biological processes such as protein phosphorylation and cellular response to growth factor stimulation. Then molecular docking and molecular dynamics validation showed that the complexes can bind tightly to target proteins in the active pocket through van der Waals, hydrophobic and π-bonds. The binding of PD-L1 to the main active ingredient may be one of the important mechanisms of its anti-NSCLC action. At last, Survival curve analysis and immunohistochemical analysis showed TP53, PIK3R1, PD-L1 and other target genes above had significant differences in expression in lung cancer patients. In conclusion, this study explored the active components of "Astragalus-Ligustrum" drug pair in anti-NSCLC and elucidated the mechanism of its action.
Unraveling the Causal Relationship between Blood Metabolites and Acne: A Metabolomic Mendelian Randomization Study
Authors: Li Min , Huang Yu-Liang , Zhan Dan Dan , Wang Yu , Hu Xiao Han , Zhang Ming , Zhou Zhou 
Published: September 2023

Abstract

Background: Acne is a prevalent skin disorder with potential links to metabolic dysfunction. The causal impact of blood metabolites on acne remains underexplored.
Methods: Using a genome-wide association dataset, we conducted a metabolome-wide Mendelian randomization (MR) analysis on 486 blood metabolites and acne. The study included preliminary IVW analysis, multivariable MR analysis, linkage disequilibrium score (LDSC)analysis, and colocalization analysis, with reverse MR to address reverse causation.
Results: We identified 12 metabolites with significant associations with acne. LDSC analysis revealed a genetic correlation between nonanoylcarnitine and acne. Colocalization analysis confirmed shared genetic variants, and metabolic pathway analysis implicated the Arginine biosynthesis pathway and the Selenocompound metabolism pathway in acne development.
Conclusion:Our study provides a comprehensive understanding of the causal relationships between plasma metabolites and acne. The findings offer insights into potential biomarkers and therapeutic targets for acne treatment and emphasize the need for further research.
Global Trends on β-thalassemia Research over 10 Years: A Bibliometric Analysis
Authors: lv aixiang , li jingmin , Chen Meihuan , Wang Wei , Xu Liang-pu , Huang Hai-long 
Published: September 2023

Abstract
Introduction
Thalassemia, an inherited quantitative globin disorder, is the most prevalent monogenic disease globally. While severe alpha thalassemia results in intrauterine death, β-thalassemia manifests during childhood due to the "second conversion of hemoglobin," garnering increased attention in recent decades.
Methods
In this study, a bibliometric analysis will be conducted of thalassemia articles published in the Web of Science Core Collection database between 2013 and 2023 to establish a comprehensive overview and to identify emerging trends. A total of 5655 studies published between 2013 and 2023 were systematically retrieved, and annual publications demonstrated a steady increase, maintaining a high level over the past decade.
Results
The United States contributed the highest number of publications, followed by China. Notably, the journal Blood emerged as the leading authority in β-thalassemia research. Analysis of research hotspots revealed that the pathogenesis of β-thalassemia is primarily linked to iron overload, anemia, gene mutations, and ineffective erythropoiesis. Furthermore, recent studies focusing on gene editing therapies present promising avenues for future investigation.
Conclusion
These findings grasp the research status of β-thalassemia and shed new light on future research frontiers.
Analytical Investigation on BER Performance and Power Spectral Density in Constant Envelope OFDM Optical Fiber Communication Systems
Authors: M Sathish Kumar. 
Published: September 2023

Abstract
Theoretical analysis of a direct detection Constant Envelope Orthogonal Frequency Division Multiplexing (CEOFDM) optical communication link is carried out with a motivation to arrive at its Bit Error Rate (BER) performance. Insights on the spectral densities of the signal as well as noise at various key points of the direct detection CEOFDM optical communication link is discussed. Improvement in the BER performance for increasing optical signal to amplified spontaneous noise power was observed. The theoretical analysis results in an interesting observation that there exists an optimum bias voltage Vb of the Mach Zehnder Modulator which optimizes the BER performance.