bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengembangan Infrastruktur Jaringan Komputer PNP PSDKU Solok Selatan Menggunakan Metode Network Development Life Cycle (NDLC)
Authors: Rosman Edwar , Flomina Katrina , Hasanah Miftahul , Febriani Widya , Gaputra Ideva 
Published: January 2025

Penelitian ini bertujuan untuk menganalisis dan merancang infrastruktur jaringan komputer di Politeknik Negeri Padang (PNP) Program Studi Di luar Kampus Utama (PSDKU) Solok Selatan guna meningkatkan performa jaringan. Saat ini ada 4 unit Optical Network Terminal (ONT) dari ISP Indihome dengan bandwidth untuk 2 ONT sebesar 100 Mbps dan 1 ONT 300 Mbps serta 1 ONT khusus sebagai akses point Wifi id untuk memenuhi kebutuhan internet Dosen, Mahasiswa dan Tenaga kependidikan. Namun terdapat permasalahan yang teridentifikasi, yakni pengelolaan bandwidth belum optimal, yang mengakibatkan bottleneck pada salah satu jalur ISP dan tidak maksimalnya penggunaan kapasitas bandwidth yang tersedia serta belum adanya back up jika salah satu ONT bermasalah. Penelitian ini menggunakan metode Network Development Life Cycle (NDLC) yang terdiri dari tahapan analisis, desain, simulasi, implementasi, monitoring, dan manajemen. Pada tahap awal dilakukan analisis kebutuhan jaringan dan perancangan topologi jaringan dengan penambahan Router. Pengujian jaringan dilakukan pada tahap akhir untuk memastikan bahwa infrastruktur jaringan yang baru mampu bekerja dengan baik. Hasil dari penelitian ini memberikan optimasi jaringan internet yang lebih baik di PNP PSDKU Solok Selatan.
Combinatorial Game Theory Meets Deep Learning:Efficient Endgame Analysis
Authors: Frejlak Stanisław 
Published: January 2025

The endgame stage of Go presents a unique challenge for scientific research. Contrary to previous stages, in the endgame the key to a successful analysis is board decomposition into smaller, independent local positions. Go players typically analyze these positions separately and prioritize moves based on their value. In this paper, I introduce a novel program that automates this decomposition-based analysis for the endgame stage of Go.
AlphaZero has revolutionized Computer Go, by applying a generic move-selection mechanism, based on neural network judgments and the MCTS search algorithm. However, it does not specifically address the complexity of endgame in the aforementioned manner. On the other hand, by leveraging the decomposition-based analysis, my program reaches decisions in the endgame with relatively little computation. Additionally, it offers insights for Go practitioners by providing accurate move value evaluations.
Notable prior work on automated endgame analysis was done by Martin Müller (1995). His program Explorer checked all possible variations in every undecided position and aggregated the results based on an algorithm inspired by the Combinatorial Game Theory (CGT). However, due to the exponential growth of the number of variations, Explorer’s application was limited to small, tightly bounded local positions.
In contrast, my program leverages a neural network to predict optimal local moves, dramatically reducing the number of variations that need to be explored. Provided that the neural network’s predictions are correct, the program can accurately evaluate move values by considering relatively few variations, just like human Go experts do. Thanks to this approach, it is the first program capable of analyzing large, unbounded local positions, which are commonly encountered in real games.
The neural network was fine-tuned from a pre-trained AlphaZero reimplementation on the task of optimal local move prediction. Training data was gathered from KataGo self-play games, utilizing KataGo’s network to perform board decomposition.
The Effectiveness Of Health Education On Public Perception and Knowledge Regarding The Use Of Garlic Extract To Lower Cholesterol in Suco Seloi Malere Aldeia Namanei Posto Administrativo Aileu Municipiu Aileu in 2024
Authors: Leny Blegur  , Rahaju Ningtyas  , Maria Goreti Owa  , Novio De Almeida Pereira  , Yoseph Uli Yanto  , Gonzalo Jose Texeira  
Published: January 2025

This study aims to evaluate effectiveness of health education on public perception and knowledge regarding the use of garlic extract to reduce cholesterol in Suco Seloi Malere Aldeia Namanei Posto Administrativo Aileu Municipiu Aileu in 2024. This research uses a quasi-experimental design with a pretest-posttest approach. Data was collected from the community in Suco Seloi Malere Aldeia Namanei Posto Administrativo Aileu Municipiu Aileu in 2024 through questionnaires before and after being given health education. Before education, 62% of respondents had moderate knowledge; After education, 64% of respondents had high knowledge about the use of garlic extract to lower cholesterol. Before education, 60% of respondents had a moderate perception; After education, 62% of respondents showed an increase in perception to high perception. Before education, 38% of respondents had little experience, after education, 98% of respondents had good experience regarding the use of garlic extract to lower cholesterol. Before education, the majority of respondents (60%) had a secondary education level. After education, the proportion of respondents with a secondary education level remained stable at 60%. Before education, 40% of respondents felt a high cultural influence regarding the use of garlic extract. After education, this figure increases to 70%. The health education provided is effective in increasing public knowledge and perception regarding the use of garlic extract to lower cholesterol.
A IMPORTÂNCIA DO FARMACÊUTICO NA ORIENTAÇÃO E ADESÃO FARMACOLÓGICA EM PORTADORES DO TRANSTORNO DO ESPECTRO AUTISTA
Authors: NASCIMENTO Ana Luisa Reis , FERREIRA Luziânia Oliveira , ROCHA Rayane de Abreu , SILVA Maria Mercês Gonçalves , SIRQUEIRA Laise Silva , ANDRADE Valéria Farias , FIGUEIREDO Flávio Junior Barbosa , PEREIRA Nayara Gonçalves , PINHEIRO Thaisa de Almeida , PINHEIRO Thales de Almeida , RUAS Luis Paulo Ribeiro , GUIMARÃES Talita Antunes 
Published: January 2025

Introduction: Autism Spectrum Disorder (ASD) is configured as a complex neurobiological disorder that affects communication and social behavior. Since there is no cure for autism, various medications can be used to help control specific symptoms, such as anxiety, hyperactivity, and sleep disturbances. Pharmacological interventions in autism are challenging due to etiological and clinical heterogeneity. Although there is no cure or adequate management, including pharmaceutical care, it is crucial to promote the quality of life of individuals with ASD. Objective: to understand the importance of pharmaceutical assistance exercised by pharmacists in the orientation and administration of medication treatments by two patients with autism spectrum disorder. Methodology: This study was carried out based on a bibliographic survey of articles in the last 5 years, regarding the proposed topic, in order to emphasize the relevance of pharmaceutical assistance in the social sphere. Results and discussion: from the searches carried out in the databases of electronic data Scielo, Google Academic and BVS, a qualitative analysis was carried out, where 6 foramed articles were selected and described according to the title and conclusion of each study. Conclusion: it can be affirmed that the presence of a pharmacist not accompanying two ASD carriers is of great importance, not that it says respect for the treatment and specific guidance and management regarding the proposed drug therapies: side effects and adverse effects, drug interactions, dosages and other relevant aspects, mitigating low adesão and possible failures in treatment.
The Impact of Midlife on Professional Life: A Study of Workplace Challenges for Women
Authors: Naila Hina Qazi  , Mumtazjehan  , Nida Hamid  , Sana Abbasi  , Rubina Mushtaq  , Uzma Manzoor  
Published: January 2025

Objective: To determine the impact of midlife on professional life by exploring the workplace challenges faced by women
Methodology: This cross-sectional study was performed on midlife working women aged 40-65 years from different fields from March 2024 to July 2024. Data were gathered utilizing a structured questionnaire that included demographic information, job stresses, physical and emotional health concerns, and professional challenges. Deep conversations were conducted with a selection of participants to provide qualitative insights. Statistical analysis, including chi-square tests and logistic regression, was undertaken to investigate the association between demographic characteristics and workplace problems.
Results: Overall mean age of women was 51.23 years. 48% women had mild depression, 18% moderate, and 12% severe. Midlife women reported major employment issues, with 36% feeling severely overworked and 44% suffering with role balance. Physical discomfort affected 52%, emotional instability was moderate to severe in 79%, and 65% reported effects on family relationships. Other issues were excessive job pressure (30%), a lack of support (35%), inadequate career advancement (32%), insufficient balance between work and life (26%), and age-related discrimination (22%). Women aged 40-50 faced higher depression, work-life imbalance, and emotional instability (p=0.001). Higher education correlated with more work stress and pain, while lower socioeconomic status linked to greater emotional instability and work-life conflicts. Married women and those with comorbidities reported higher depression and physical pain (p<0.05.
Conclusion: Study concluded that the midlife has a substantial impact on women's professional lives, with common issues such as work-life balance, volatile emotions, and physical discomfort. Age discrimination, had also a negative impact on job satisfaction and career advancement.
The Effect of Dietary Sodium Alginate on the Growth and Survival of Giant Freshwater Prawn (Macrobrachium rosenbergii)
Authors: Rana Rushirajsinh J. , Kotiya A. S. , Jungivala Mansi D. , Sakariya Kishan 
Published: January 2025

The giant freshwater prawn, Macrobrachium rosenbergii, is a valuable aquaculture species known for its rapid growth, adaptability to environmental variations, and high nutritional value. However, challenges such as high mortality rates, algal blooms, dissolved oxygen depletion, and pathogen outbreaks constrain its cultivation. The overuse of antibiotics in aquaculture raises significant environmental and health concerns, including antimicrobial resistance. This study explores the potential of sodium alginate, a natural polysaccharide derived from brown algae, as a prebiotic and immunostimulant for improving growth and feed efficiency in M. rosenbergii. Juvenile prawns (~0.2 g) were cultured for 60 days and fed experimental diets supplemented with sodium alginate at concentrations of 0 g/kg (control, T0), 1.0 g/kg (T1), 2.0 g/kg (T2), and 3.0 g/kg (T3). Growth performance, feed utilization, and survival rates were assessed bi-weekly. Results showed significant improvements (p<0.05) in growth parameters, including mean weight gain (MWG) and specific growth rate (SGR), in prawns fed a 2.0 g/kg sodium alginate diet (T2). At the end of the experiment, T2 recorded the highest mean weight, MWG, SGR, and lowest feed conversion ratio (FCR, 2.395 ± 0.068), demonstrating superior feed utilization efficiency. In contrast, prawns fed a 3.0 g/kg sodium alginate diet (T3) showed reduced growth performance and feed efficiency. This study highlights the efficacy of sodium alginate as a dietary supplement to enhance growth, feed efficiency, and sustainability in freshwater prawn aquaculture, with the optimal dosage identified as 2.0 g/kg. These findings support sodium alginate's potential as an eco-friendly alternative to antibiotics in aquaculture systems.
Endothelial Biomarkers of Systemic Sclerosis–Associated Pulmonary Hypertension
Authors: Lammi Matthew R. , Kolstad Kathleen D. , Saketkoo Lesley Ann , Khatri Avani , Utz Paul J. , Steen Virginia D. , Chung Lorinda 
Published: June 2023

ObjectiveDespite efforts at early detection, patients with systemic sclerosis (SSc) pulmonary hypertension (PH) present with advanced disease. We sought to determine whether endothelial biomarkers (asymmetric dimethylarginine [ADMA], soluble endoglin [sEng], and pentraxin‐3 [PTX‐3]) can determine SSc‐PH risk or differentiate between SSc‐PH subgroups.MethodsADMA, sEng, and PTX‐3 were measured by enzyme‐linked immunosorbent assay in four groups: 1) 18 healthy controls, 2) 74 patients with SSc‐PH, 3) 44 patients at high risk for PH features, and 4) 10 patients with low risk for PH features. High‐risk features included a diffusion capacity (DLco) less than 55% with a forced vital capacity (FVC) greater than 70%, an FVC/DLco ratio of >1.6, or a right ventricular systolic pressure on an echocardiogram greater than or equal to 40 mm Hg. ADMA, sEng, and PTX‐3 were compared between these four groups as well as stratified based on the three SSc‐PH clinical classification groups (pulmonary arterial hypertension [PAH], left‐heart disease, and interstitial lung disease [ILD]).ResultsPTX‐3 was significantly lower in subjects with SSc at low risk for PH (median 27.0 pg/ml [interquartile range (IQR) 19.0–47.3]; P < 0.003) than the other groups. The area under the receiver operating characteristic curve was 0.87 (95% confidence interval 0.76–0.98, P = 0.0002) to differentiate low risk from high risk for patients with PH. PTX‐3 was significantly lower in SSc‐PH from disease of the left side of the heart (57.5 pg/ml [IQR 39.8–79.0]; P < 0.01) compared to SSc‐PH from either PAH (85.5 pg/ml [IQR 56.3–104.5]) or ILD (90.3 pg/ml [IQR 74.9–111.0]). Neither ADMA nor sEng differed between the four groups.ConclusionPTX‐3 is a promising biomarker of PH risk status in patients with SSc as well as a possible marker of precapillary PH, which should be validated in an external cohort.image
Nanoassemblies Derived from Natural Flavonoid Compounds as New Antioxidant Oral Preparations for Targeted Inflammatory Bowel Disease Therapy
Authors: Tang Nan , Ding Zhen , Zhang Siqi , Luo Danfeng , Liu Xiaocan , Bao Xingfu , Liu Chaoyong , Liu Zhen 
Published: June 2023

AbstractPossessing the largest surface area of mucosa in the body, the gastrointestinal (GI) tract can easily sufferfrom inflammatory damage under various adverse external exposures, resulting in the occurrence of inflammatory bowel disease (IBD). Excessive reactive oxygen species (ROS) usually lead to local mucosal injury, accelerate the formation of niduses, andamplify the inflammatory and immune response. Antioxidant therapy, therefore, is considered as a potential strategy against IBDs. Herein, a series of novel dihydromyricetin‐based nanoassemblies with excellent antioxidant activities and high dispersion in GI tract as oral preparations are developed for the targeted IBD treatment. By changing raw materials, the current strategy can be well extended to the preparation of other insoluble natural flavonoid compound‐based nanoassemblies. The well‐designed dihydromyricetin‐PEG 1000‐based nanoassemblies (DMY‐1000 NAs) with high stability and great ROS scavenging capacity in the harsh environment of GI tract hold an admirable targeted capability toward the intestinal inflamed lesions. Therefore, these biocompatible DMY‐1000 NAs show promising therapeutic effects for typical IBDs including ulcerative colitis and Crohn's disease in murine models. This study not only provides a new method for constructing antioxidant therapy platforms but also illustrates their prominent therapeutic promise against IBDs.
Controlled Quenching of Agarose Defines Hydrogels with Tunable Structural, Bulk Mechanical, Surface Nanomechanical, and Cell Response in 2D Cultures
Authors: Piazza Francesco , Parisse Pietro , Passerino Julia , Marsich Eleonora , Bersanini Luca , Porrelli Davide , Baj Gabriele , Donati Ivan , Sacco Pasquale 
Published: June 2023

AbstractThe scaffolding of agarose hydrogel networks depends critically on the rate of cooling (quenching) after heating. Efforts are made to understand the kinetics and evolution of biopolymer self‐assembly upon cooling, but information is lacking on whether quenching might affect the final hydrogel structure and performance. Here, a material strategy for the fine modulation of quenching that involves temperature‐curing steps of agarose is reported. Combining microscopy techniques, standard and advanced macro/nanomechanical tools, it is revealed that agarose accumulates on the surface when the curing temperature is set at 121 °C. The inhomogeneity can be mostly recovered when it is reduced to 42 °C. This has a drastic effect on the stiffness of the surface, but not on the viscoelasticity, roughness, and wettability. When hydrogels are strained at small/large deformations, the curing temperature has no effect on the viscoelastic response of the hydrogel bulk but does play a role in the onset of the non‐linear region. Cells cultured on these hydrogels exhibit surface stiffness‐sensing that affects cell adhesion, spreading, F‐actin fiber tension, and assembly of vinculin‐rich focal adhesions. Collectively, the results indicate that the temperature curing of agarose is an efficient strategy to produce networks with tunable mechanics and is suitable for mechanobiology studies.
Dark Exciton in 2D Hybrid Halide Perovskite Films Revealed by Magneto‐Photoluminescence at High Magnetic Field
Authors: Zhang Chuang , Jiang Xiaomei , Sercel Peter C. , Lu Haipeng , Beard Matthew C. , McGill Stephen , Semenov Dmitry , Vardeny Z. Valy 
Published: June 2023

AbstractA comprehensive study of the exciton fine structure (EFS) is presented in 2D‐phenethylammonium lead iodide films using magnetic field‐induced polarization of photoluminescence (PL) in both Faraday and Voigt configurations at fields up to 25 Tesla. Three exciton bands are identified in the PL spectrum associated with bound, dark, and bright excitons, respectively. Under a high magnetic field in Faraday/Voigt configuration, large field‐induced circular/linear polarization is observed in the PL band related to the dark exciton, which is magnetically activated. Furthermore, it is found that the dark exciton has an anomalous field‐induced circular polarization, which cannot be explained by the classical Boltzmann distribution of spin‐polarized species. These findings are well explained by an effective mass model that includes exchange terms unique to the monoclinic symmetry as a perturbation of the EFS in the approximate tetragonal symmetry. It is also confirmed that the field‐induced linear polarization is sensitive to the monoclinic exchange term, whereas the field‐induced circular polarization is immune to such term.
Dehydrogenative Fluorination of gem‐Difluoroalkenes to Access Multi‐Substituted Trifluoromethylalkenes
Authors: Wang Manman , Wu Mengyu , Ma Rui , Chen Kai , Zhu Chuan , Feng Chao 
Published: June 2023

AbstractA dehydrogenative fluorination method is developed to access multi‐substituted trifluoromethylalkenes starting from a variety of gem‐difluoroalkenes. The reaction proceeds with electrophilic fluorination source NFSI only and accommodates a wide range of functional groups, thus complementing the previously reported protocols. Additionally, a visible‐light‐promoted stereoinversion is revealed to enable the access to E‐isomer enriched products.
A Nanocarrier Approach for Oral Peptide Delivery: Evaluation of Cell‐Penetrating‐Peptide‐Modified Liposomal Formulations in Dogs
Authors: Uhl Philipp , Bajraktari‐Sylejmani Gzona , Witzigmann Dominik , Bay Cindy , Zimmermann Stefan , Burhenne Jürgen , Weiss Johanna , Haefeli Walter E. , Sauter Max 
Published: June 2023

AbstractOral delivery of peptides is severely limited by their instability and poor absorption in the gastrointestinal tract. In contrast to coadministration strategies using medium‐chain fatty acids, which have recently gained regulatory approval with low oral bioavailabilities ≤ 1% (Rybelsus and Mycapssa), efforts to clinically implement delivery systems based on nanocarriers have not been successful to date. The approved drug‐delivery formulations show fairly accurate correlation between clinical results and nonrodent mammal bioavailability, including Beagle dogs for Rybelsus, indicating that Beagle dogs represent a translationally relevant model. Here, a nanocarrier formulation for the oral administration of peptide therapeutics is reported with systemic targets consisting of liposomes decorated with cyclic cell‐penetrating peptides, which significantly increase oral bioavailability in translationally relevant Beagle dogs. This nanocarrier formulation is optimized using the glycopeptide vancomycin, and results in a considerable oral bioavailability of 3.9%. Further, this nanocarrier system increases the oral bioavailability of the large linear peptide therapeutic exenatide 20‐fold, and consistently achieves effective plasma concentrations in Beagle dogs.
Dual‐Supporter and Dual‐Salt Strategy for Solid Polymer Electrolyte with High Ionic Conductivity and Elastic Toughness
Authors: Lee Hyo Chan , Kim Min‐Jae , Kim Myeong‐Hyeon , Yoon Tae Woong , Kim Myeong‐Eun , Lee Hwa Sung , Ham Dong Seok , Lee Dongki , Ha Chaeyeon , Kim Young‐Jun , Kang Boseok 
Published: June 2023

AbstractIn recent years, ionic liquid (IL)‐based solid polymer electrolytes (SPEs) have attracted much attention as conducting or capacitive materials for stretchable electronics. To fabricate fast and mechanically robust electronic devices, the high ionic conductivity and high elastic toughness of the SPE are essential. However, it has been challenging to achieve both high ionic conductivity and high elastic toughness simultaneously because high ionic conductivity generally requires low crystallinity of the polymer chains. Herein, a facile strategy for fabricating highly conductive, mechanically robust, and thermally stable SPE is demonstrated. A glass fiber mesh and La0.57Li0.29TiO3 particles as dual‐supporters are introduced, and 1‐ethyl‐3‐methylimidazolium bis(trifluoromethylsulfonyl)imide ([EMIM][TFSI]) and bis(trifluoromethylsulfonyl)amine lithium salt (LiTFSI) (having the same anion) as the dual salt in the polymer electrolyte is introduced. Consequently, the SPE exhibits a superior ionic conductivity of 2.4 × 10−2 S cm−1 at room temperature and an outstanding elastic toughness of ≈170.3 kJ m−2. Finally, the dual‐salt/dual‐supporter SPE is successfully applied to high‐performance organic electrolyte‐gated transistors as gate dielectric materials and highly sensitive capacitive pressure sensors as force‐sensitive dielectric layers.
Double jeopardy: COVID‐19, coup d'état and poverty in Myanmar
Authors: Boughton Duncan , Headey Derek , Mahrt Kristi , Cho Ame , Diao Xinshen , Lambrecht Isabel , Minten Bart , Goeb Joey , Masias Ian , Belton Ben , Aung Nilar , San Cho Cho 
Published: June 2023

AbstractMyanmar experienced multiple COVID shocks as well as a military takeover in February 2021. Impacts on household poverty remain uncertain, however, because large‐scale in‐person surveys were impossible during the pandemic and heightened internal conflict. We use ex ante simulation models and phone survey evidence to estimate the poverty effects of these shocks and identify factors correlated with them. While each approach has limitations, and cannot explicitly validate each other, they both indicate rising rural and urban poverty and capital‐depleting coping mechanisms. Wider use of simulation modeling could help mobilize social protection faster than waiting for survey results in emergencies.