bluuebunny/crossref_metadata_2025_split huggingface dataset:
Aplikasi Bakteri Endofit sebagai Pengendali Penyakit Hawar Pelepah secara In Vitro dan In Vivo
Authors: Utami Oktavia Rezky 
Published: June 2023

Penelitian bertujuan untuk menentukan isolat bakteri endofit akar padi yang mampu mengendalikan hawar pelepah padi (R. solani) secara in vitro dan in vivo serta menentukan kerapatan isolat bakteri endofit akar padi. Penelitian dilaksanakan secara in-vitro di Laboratorium Perlindungan Tanaman Fakultas Pertanian Universitas Jenderal Soedirman Purwokerto dan in vivo di Rumah Kasa Desa Tambaksari Kidul. Pada bulan Desember 2021 sampai dengan Juni 2022. Penelitian menggunakan Rancangan Acak Lengkap (RAL) pada uji in vitro dengan jumlah perlakuan yang diujikan sebanyak 6 perlakuan dan 4 kali ulangan dan Rancangan Acak Kelompok (RAK) uji in vivo dengan jumlah perlakuan yang diujikan sebanyak 6 perlakuan dan 4 kali ulangan dengan 3 tanaman setiap perlakuan sehingga diperoleh 72 tanaman. Perlakuan meliputi (kontrol) R. solani (P0), isolat bakteri A5 x R. solani (P1), isolat bakteri A6 x R. solani (P2), isolat bakteri KR4 x R. solani (P3), isolat bakteri KR7 x R. solani (P4) dan isolat bakteri SB3 x R. solani (P5). Hasil menunjukkan semua perlakuan isolat bakteri endofit memiliki potensi yang sama dalam menghambat pertumbuhan jamur patogen R. solani. Perlakuan P1 (isolat A5) memiliki daya hambat tertinggi yaitu 63,38 % dan pada perlakuan P4 (isolat KR7) memiliki daya hambat terendah yaitu 46,55 %. Bakteri endofit pada perlakuan P2 (isolat A6) mampu mengendalikan hawar pelepah padi karena memiliki nilai intensitas penyakit serta nilai AUDPC paling rendah yaitu sebesar 12,07% dan AUDPC sebesar 215,31%.hari. Nilai kerapatan bakteri endofit tertinggi terdapat pada isolat KR4 sebesar 131,93 x 108 cfu/ml dan terendah terdapat pada isolat SB3 sebesar 4,63 x 108 cfu/ml. Kata kunci : bakteri endofit, Rhizoctonia solani, hawar pelepah.
Analisis Kesalahan Penulisan Aksara Jawa Pada Papan Nama Jalan di Kota Surakarta
Authors: Nugroho Himawan Adi , Sulaksono Djoko , Rahmat Rahmat 
Published: June 2023

<p><em>This study aims to describe the unfitting usage of Aksara Jawa (Javanese script) found on the street name signs in Surakarta City. This study used descriptive qualitative method with case studies approach Surakarta City. Data sources used in this study include places (street name signs bards with Javanese script) and documents (Paugeran Sriwedari 1926 and tiga Gubernur 1996). Purposive sampling method is selected for this study for specific purpose. Findings indicate that (1) Unfitting usage of carakan, sandhangan, murda, and swara in Aksara Jawa was found on the street name signs in Surakarta City in accordance with Sriwedari and Tiga Gubernur guideliness</em><em>.</em><em></em></p>
Analisis Pembentukan Kata dan Makna Leksikal Penaman Umbul Di Kabupaten Klaten Serta Relevansinya Sebagai Materi Ajar Teks Deskriptif Peristiwa Budaya di Sekolah Menengah Pertama
Authors: Rahmmawati Rofika Ayu , Suryanto Edy , Rahadini Astiana Ajeng 
Published: June 2023

<p><em>This research is based on language learning in understanding a discourse. Morphological analysis and lexical meaning can help students and educators more easily understand discourse, especially descriptive texts of cultural events. Learning descriptive text of cultural events is contained in Basic Competencies, in Grade VII, Junior High School in 2013 curriculum, Central Java Province. In addition, it can enrich new vocabulary, especially in Javanese. Researchers have brought up the naming of umbul in Klaten Regency with the aim of introducing potential to the younger generation by learning the Javanese language in particular. The name of the umbul or feather is also suitable as a research object with a study of morphology and lexical meaning. The morphological processes found include: zero derivation, application, abbreviation, composition. The lexical meanings found are described according to the origin of the name umbul or feathers, which are divided into the following categories: tree names, animal names, leaf names, figures/figures, object names, genus, hamlet name, village name, building, geographical situation, character based on of location near another building, verb, form. The object retrieval technique is targeted sampling and snowball sampling. Data collection techniques using face-to-face or fishing techniques, recording techniques, note-taking techniques. The validity test used theoretical triangulation and data source triangulation from both informants and external supporting data. Data analysis procedures using fixed methods of comparison include: data reduction. Categorization, synthesis, formulation of working hypotheses. The results of the study are relevant for learning descriptive texts of cultural events KD 3.1 understands the content of descriptive texts about cultural events and KD 4.1 Responds to the content of descriptive texts about cultural events, in addition, it can promote the character of students responsible for the environment.</em></p>
Konflik Batin Tokoh Karsana dalam Novel Tabon Karya Margareth Widhy Pratiwi
Authors: Puspitasari Novi , Rohmadi Mohammad , Kurwidaria Favorita 
Published: June 2023

<p><em>Conflict is a special attraction for readers of literary works. Moreover, the conflict experienced by the character. Therefore, an in-depth analysis is needed to find out the inner conflicts contained in a literary work. Novels are a type of literary work that tells the story of people's lives where the conditions for the conflicts of the characters. The purpose of this study is to describe the inner conflict of the character Karsana in the novel Tabon by Margareth Widhy Pratiwi. This research is in the form of a qualitative descriptive using a literary psychology approach. The data of this study are quotes and dialogues contained in the novel Tabon by Margareth Widhy Pratiwi. The sources of data of this study are documents. The sampling technique in this study used purposive sampling technique. The data collection techniques used are document analysis. The validity test techniques used are theoretical triangulation and source triangulation. Data analysis techniques use interactive analysis techniques. The research procedure includes three stages, namely the preparatory stage, the research implementation stage, and the presentation stage of the research results. The result of this study is that </em><em>K</em><em>arsana figures experience id dominance so that the personality structure in Karsana's character is an unbalanced personality.</em></p><p> </p>
“Can You Feel It”: An Early Experience with Simulated Vibration to Recreate Glenoid Reaming
Authors: Strelzow Jason A. , Kusins Jonathan R. , Ferreira Louis M. , LeBel Marie-Eve 
Published: June 2023

Background:
When developing educational simulators, meaningful haptic feedback is important. To our knowledge, no shoulder arthroplasty surgical simulator exists. This study focuses on simulating vibration haptics of glenoid reaming for shoulder arthroplasty using a novel glenoid reaming simulator.

Methods:
We validated a novel custom simulator constructed using a vibration transducer transmitting simulated reaming vibrations to a powered nonwearing reamer tip through a 3D-printed glenoid. Validation and system fidelity were evaluated by 9 fellowship-trained shoulder surgeon experts performing a series of simulated reamings. We then completed the validation process through a questionnaire focused on experts' experience with the simulator.

Results:
Experts correctly identified 52% ± 8% of surface profiles and 69% ± 21% of cartilage layers. Experts identified the vibration interface between simulated cartilage and subchondral bone (77% ± 23% of the time), indicating high fidelity for the system. An interclass correlation coefficient for experts' reaming to the subchondral plate was 0.682 (confidence interval 0.262-0.908). On a general questionnaire, the perceived utility of the simulator as a teaching tool was highly ranked (4/5), and experts scored “ease of instrument manipulation” (4.19/5) and “realism of the simulator” (4.11/5) the highest. The mean global evaluation score was 6.8/10 (range 5-10).

Conclusions:
We examined a simulated glenoid reamer and feasibility of haptic vibrational feedback for training. Experts validated simulated vibration feedback for glenoid simulation reaming, and the results suggested that this may be a useful additional training adjuvant.

Level of Evidence:
Level II, prospective study.
Biweekly CAPOX versus Triweekly CAPOX in the adjuvant therapy of post-surgery CRC: a randomized controlled trial
Authors: Zhang Hangyu , Wang Danyang , Tong Zhou , Xiang Tao , Dai Xiaomeng , Bao Xuanwen , Zhu Xudong , Liu Lulu , Zheng Yi , Zhao Peng , Fang Weijia , Chen Wenbin 
Published: June 2023

Abstract
Background: Adjuvant CAPOX (capecitabine plus oxaliplatin) provided significant disease-free survival (DFS) benefit in patients with high-risk stage II or stage III colorectal cancer (CRC). Conventional triweekly CAPOX results in 14-38% 3-4 grade hematological toxicity. Modified biweekly CAPOX was observed to be generally well-tolerated in previous studies.
Methods: High-risk stage II and stage III post-surgery CRC patients were randomized in the control triweekly group (intravenous infusion of oxaliplatin 130 mg/m2 on day 1 and oral capecitabine 1000 mg/m2, twice daily from d1 to d14) and the experimental biweekly group (intravenous infusion of oxaliplatin 85 mg/m2 on day 1 and oral capecitabine 1000 mg/m2, twice daily from d1 to d10). The primary endpoint was incidence of thrombocytopenia. The secondary endpoint was 18-month DFS rate.
Results: Between Jul 25, 2018, and May 14, 2021, 160 patients were 1:1 randomly enrolled and received treatment. The primary endpoint thrombocytopenia occurred 33% and 49% in biweekly and triweekly group (P=0.02). The second endpoint 18-month DFS in 3-month group was 94.1% in biweekly CAPOX group, and 93.8% in triweekly CPOX group (P=0.96). Neutropenia was 36% and 51% in biweekly and triweekly group, respectively (P=0.04). The rate of uncomplete therapy patient was 7% and 15% in biweekly and triweekly group, respectively (P=0.13).
Conclusion: Biweekly CAPOX presented significant less thrombocytopenia and neutropenia than triweekly CAPOX regimen. And biweekly CAPOX did not affect the 18-month DFS rate.
Clinical trial registration: First registration date: 21/06/2018. ClinicalTials.gov (NCT03564912).
Application of postoperative analgesia with different doses of nalbuphine in children with cleft palate
Authors: Chen Zhan-ming , Gao Bao-hua , Wang Liang-shan 
Published: June 2023

Abstract
Background: Cleft palate repair surgery may result in severe pain in the immediate postoperative period. This study aims to compare the effects of different doses of nalbuphine on postoperative analgesia in children with cleft palate.
Methods: From September 2019 to June 2021, 90 children (45 males and 45 females, 9-20 months old, ASA Ⅰ - Ⅱ) were selected for palatoplasty. They were randomly divided into three groups: control group (Group C), postoperative analgesia nalbuphine 0.05mg/kg/h (N1 group) and postoperative analgesia nalbuphine 0.075mg/kg/h (N2 group), 30 cases in each group. No analgesia drug was used in group C, and the postoperative analgesia regimen in group N1 and N2 was continuous pump infusion of nalbuphine 0.05mg/kg/h and 0.075mg/kg/h. For 24 hours. FLACC analgesia score and Ramsay Sedation score were recorded at 10min (T1), 30min (T2), 2h (T3), 12h (T4) and 24h (T5) after operation. Adverse reactions such as nausea, vomiting and respiratory depression were observed and recorded.
Results: Compared with group C, FLACC scores of N1 and N2 groups decreased significantly at T1-T5 (p<0.05); Ramsay Sedation score in N1 group was significantly higher at T3 and T4 (p<0.05), and that in N2 group was significantly higher at T1-T5 (p<0.05). Compared with N1 group, there was no significant difference in FLACC score in N2 group, and Ramsay Sedation score increased significantly at T5 (p<0.05).
Conclusion: Using Nalbuphine with 0.05mg/kg/h continuous for 24 hours for postoperative analgesia in children with cleft palate has better effect and less adverse reactions.
Trial registration: This study was registered at (ChiCTR1900027385，11/11/2019)
Empirical approches for non-linear site response: results from the ESG6-blind test.
Authors: REGNIER Julie , Bard Pierre-Yves , Castro-Cruz David , Derras Boumédiène , Bertrand Etienne 
Published: June 2023

Abstract

As a contribution to step 3 of the ESG6 blind prediction exercise, we present an application of two different, purely empirical approaches to estimate the strong ground motion at a soft site ("KUMA") from the observed ground motion at a reference rock site ("SEVO") for the two largest shocks of the Kumamoto 2016 sequence (a foreshock with Mj=6.5, and the mainshock with Mj=7.3). The two methods estimate the non-linear transfer function between a reference rock and a sedimentary site by modifying the linear transfer function derived from weak motion recordings. The modification is based either on a machine learning tool based on a wide collection of Japanese weak and strong motion recordings and the associated site metadata (method M1), or on an estimate of a site-specific parameter related to an average non-linear site response (M2). The acceleration time series are then derived at the sedimentary site of interest using an estimation of the time delay between wave arrivals at the rock and site stations, and a minimum phase assumption for the site transfer function.
These predictions were made blindly, but after the ESG6 conference they could be compared both with the actual ground motion recorded at KUMA during the two shocks, and the average and range of all other predictions preformed for this benchmark.
The quality of predictions is quantified through various "goodness of fit" (GOF) measures. The agreement may be considered as "excellent" for the foreshock and "good" for the mainshock for usual engineering ground motion parameters (peak values, response spectra, integral parameters), but is very poor in terms of waveform details – as usual for all ground motion predictions even in the linear domain –. The performance of these two purely empirical approaches is at least comparable to those of the numerical simulation methods for the foreshock – if not better -, and slightly worse for the (largest) mainshock. This may come either from an underestimation of non-linear effects, or from the relatively large distance (8 km) between the reference and the target site which limits the reliability of the empirical transfer functions and thus the applicability of the approaches used here for such an instrumental layout.
Both of these purely empirical methods provide an honorable prediction of the Fourier spectra and acceleration time histories of the two target events, as the methods required only recordings of weak motions at the target and a referent sites and very simple description of the soil profile. The use of moderate motions to constrain the frequency shift prediction for the second method and the consideration of an alternative phase modification are possible ways to improvement.
Fetal mesenchymal stem cells promote osteogenesis via Notch signaling
Authors: Lee Jaemin , An Hyun-Ju , Rim Jong Seop , Kong Taeho , Won Jihye , Kim Junsung , Shim So Hyun , Lee Soonchul 
Published: June 2023

Abstract

Background Mesenchymal stem cells (MSCs) as a source of osteoblasts play a key role in bone repair and regeneration. Fetal mesenchymal stem cells (Fetal-MSCs) exhibit lower immunogenicity, higher potential for expansion, and higher differentiation potential into various cell lineages than adult MSCs. Herein,in vitroandin vivoevaluations were performed to study the role of human Fetal-MSCs in osteogenic differentiation and bone regeneration in comparison to that of adult bone marrow mesenchymal stem cells (BM-MSCs). Methods Fetal-MSCs were isolated from fetal tissues derived from ectopic pregnancy at eight and half and half weeks of gestation and studied for karyotypic stability, proliferation over successive passages, and expression of embryonal and mesenchymal markers using flow cytometry. The ability of BM-MSCs and Fetal-MSCs to differentiate into osteoblasts was assessed using alkaline phosphatase (ALP) and alizarin red staining(ARS). The expression of osteogenic markers such as ALP, osteopontin(OPN), RUNX2, and osteocalcin(OCN) was evaluated using quantitative reverse transcription polymerase chain reaction. mRNA sequencing was performed to identify the differences in gene expression between Fetal-MSCs and BM-MSCs. In addition, their effects were assessed in rat calvarial defect model using micro-computed tomography, immunohistochemistry, and histological examination. Results Fetal-MSCs were more efficient than BM-MSCs in promoting osteogenesis and had a greater bone regeneration capacityin vitroandin vivo. In particular, Hairy ears Y-linked (HEY)1andHEY2, which are involved in osteoblast development, showed a significantly high differential expression between Fetal-MSCs and BM-MSCs and were the key target genes in the Notch signaling pathway. Notch signaling plays a key role in the osteogenic differentiation of Fetal-MSCs. Conclusions We demonstrated for the first time that Notch signaling plays a key regulatory role in promoting the osteogenic differentiation of Fetal-MSCs. In addition, Fetal-MSCs with their strong bone formation ability may be a promising alternative to adult-derived MSCs for bone disease treatment.
Using AI to Identify Chest Radiographs with No Actionable Disease in Outpatient Imaging
Authors: Mansoor Awais , Schmuecking Ingo , Ghesu Florin-Cristian , Georgescu Bogdan , Grbic Sasa , Vishwanath R S , Farri Oladimeji , Gosh Rikhiya , Vunikili Ramya , Zimmermann Mathis , Sutcliffe James , Mendelsohn Steven , Gefter Warren , Comaniciu Dorin 
Published: June 2023

Abstract
Background: Chest radiographs are one of the most frequently performed imaging examinations in radiology. Chest radiograph reading is characterized by a high volume of cases, leading to long worklists. However, a substantial percentage of chest radiographs in outpatient imaging are without actionable findings. Identifying these cases could lead to numerous workflow efficiency improvements.
Objective: To assess the performance of an AI system to identify chest radiographs with no actionable disease (NAD) in an outpatient imaging population in the United States.
Materials and Methods: The study includes a random sample of 15,000 patients with chest radiographs in posterior-anterior (PA) and optional lateral projections from an outpatient imaging center with multiple locations in the Northeast United States. The ground truth was established by manually reviewing procedure reports and classifying cases as non-actionable disease (NAD) or actionable disease (AD) based on predetermined criteria. The NAD cases include both completely normal chest radiographs without any abnormal findings and radiographs with non-actionable findings. The AI NAD Analyzer1 trained on more than 1.3 million radiographs provides a binary case level output for the chest radiographs as either NAD or potential actionable disease (PAD). Two systems A (more specific) and B (more sensitive) were trained. Both systems were capable of processing either frontal only or frontal-lateral pair.
Results: After excluding patients < 18 years (n=861) as well as the cases not meeting the image quality requirements of the AI NAD Analyzer (n=82), 14057 cases (average age 56±16.1 years, 7722 women and 6328 men) remained for the analysis. The AI NAD Analyzer with input consisting of PA and lateral images, correctly classified 2891 cases as NAD with concordance between ground truth and AI, which is 20.6% of all cases and 29.1% of all ground truth NAD cases. The miss rate was 0.3% and included 0.06% significant findings. With a more specific version of the AI NAD Analyzer (System A), there were 12.2% of all NAD cases were identified correctly with a miss rate of 0.1%. No cases with critical findings were missed by either system.
Conclusion: The AI system can identify a meaningful number of chest radiographs with no actionable disease in an outpatient imaging population with a very low rate of missed findings.
1For research purposes only. Not for clinical use. Future commercial availability cannot be guaranteed.
Genomic and epidemiological analysis of SARS-CoV-2 variants isolated in Guinea: A routine sequencing implementation.
Authors: Mbaye Aminata , Diallo Haby , GNIMADI Thibaut , Kadio Kadio , SOUMAH Abdoul , Koivogui Joel , Monemou Jean , Povogui Moriba , KABA Djiba , HOUNMENOU Castro , SERRANO Laetitia , Butel Christelle , Fernandez Nicolas , VIDAL Nicole , Guichet Emilande , Delaporte Eric , Ayouba Ahidjo , Peeters Martine , Toure Abdoulaye , Keita Alpha 
Published: June 2023

Abstract
Background
Several variants of SARS-CoV-2 have a demonstrated impact on public health, including high and increased transmissibility, severity of infection and immune escape. Therefore, this study aimed to describe the genetic modifications and distribution of SARS-CoV-2 lineages and better characterize the dynamics of the pandemic during the different waves that occurred in Guinea.
Methods
Nasopharyngeal samples of 24638 and socio Demographic data were collected from consent patients in consultation at the health centers of Gbessia, Kenien and Matam, in the Republic of Guinea. Virus quantification of nasopharyngeal samples was performed by quantitative PCR. 363 samples with Ct values under 30 were sequenced on Illumina iSeq 100 platform. The sequences were then analyzed using GeVarli pipeline to generate consensus sequences, variants calling, and lineage classifications (using Nextclade and Pangolin). The phylogenetic tree was constructed using Nextstain tools. Statistical analysis was done using R programming.
Results
The circulation of SARS-CoV-2 in Guinea can be distributed in three periods independent to waves. The first lasting from May to June 2020 was characterized by one lineage B1 (n=6). The second period from January 2021 to July 2021 was characterized by the lineages B.1.1.7 (Alpha, n=25), AY.122 (Delta; n=2), B.1.1.318 (n=8), R1 (n=7), B.1.525 (n=9) and B.1.629 (n=13). The third period, between December 2021 and March 2023, was characterized by the Omicron variant, with nine sub-variants in the majority. In addition, detection of variants in the period out of there circulation were documented.
Conclusion
In summary, SARS-CoV-2 genomic surveillance projects like AFROSCREEN help African scientists to contribute to describe the natural history of the COVID epidemic and to implement a routine sequencing capacity using next generation sequencing platforms. This successful implementation system for SARS-CoV-2 must be adapted for other diseases. However, the organization of sample collection and conservation is a big challenge in Africa.