bluuebunny/crossref_metadata_2025_split huggingface dataset:
A study of post‐traumatic stress disorder in schizophrenic patients 35 years after experiencing the Tangshan earthquake
Authors: Ma Wenyou , Lei Rong , Sun Yan , Liang Xiaoliang , Zhang Shun , Wang Changqi , Tang Ying , Wang Gang , Li Hebin , Yu Zhenjian 
Published: April 2023

AbstractBackgroundThis study aimed to investigate the relationship between dissociative experiences, post‐traumatic stress disorder (PTSD), and psychiatric symptoms exhibited by schizophrenic patients 35 years after the Tangshan earthquake.MethodsSeventy‐one schizophrenic patients who had experienced the Tangshan earthquake were selected and evaluated by the Post‐traumatic Dissociative Experience Questionnaire (PDEQ), thPTSD Checklist‐Civilian Version (PCL‐C), and the Positive and Negative Symptom Scale (PANSS).ResultsThe score of Group B (re‐experiencing symptoms) in PCL‐C was significantly positively correlated with age and significantly negatively correlated with the course of schizophrenia. Both gender and marriage were significantly positively correlated with the score of PCL‐C Group D (irritability symptoms caused by hyperarousal). The PDEQ score was negatively correlated with thecourse of schizophrenia and positively correlated with the presence of sleep difficulties. Significant differences were found between the PCL‐C scores of the positive and negative symptoms of the three core symptom groups; the positive rate of Group B was significantly higher than that of Group D, and the positive rate of Group C was significantly higher than that of Group D. The PCL‐C total score was positively correlated with the negative symptom factor score of PANSS; Group C's symptoms were significantly negativelycorrelated with the positive factor score of PNASS; andGroup D's‘ symptoms were significantly negatively correlated with the PANSS total score and the positive factor score.ConclusionWhen consiering patients with schizophrenia post the Tangshan earthquake, age, gender, and marital status were all positively correlated with PTSD. The course of schizophrenia was negatively associated with PTSD and dissociative experiences. PTSD was positively correlated with the negative symptoms of schizophrenia and negatively correlated with the positive symptoms of schizophrenia. Thus, the conditions and symptoms of PTSD may interact with those of schizophrenia.
Measuring the bandwagon effect: Development of a generalized bandwagon luxury motivation scale
Authors: Eastman Jacqueline Kilsheimer , Iyer Rajesh 
Published: April 2023

AbstractThis study presents a reliable, valid, and generalizable four‐item unidimensional scale that captures general bandwagon luxury motivation. After a thorough review of the bandwagon luxury literature, the authors developed an initial set of items which were then reviewed by academic experts. The scale was tested in a series of four studies to refine the scale and demonstrate its reliability and validity: Study 1 was conducted with a student sample in the Southeast, Study 2 with a student referral sample of adults in the Midwest, Study 3 with a national Qualtrics panel sample in the United States, and Study 4 with another national Qualtrics panel sample in the United States that included only those who had bought or consumed a luxury product in the past 12 months. Study 4 was done to corroborate the evidence from Study 3 with a sample of luxury consumers. The generalized bandwagon luxury motivation scale is positively related to status consumption motivation, congruity with one's internal self, a preference for visible luxury brands, and conspicuous consumption. It is negatively related to the inconspicuous luxury motivation of being unknown to the masses and independent self‐construal. This research contributes to the literature by developing a generalized scale to measure the luxury bandwagon effect that is not limited to one luxury product domain.
Right atrial and pulmonary cement embolization following vertebral laminectomy: An incidental finding
Authors: Borjian Solmaz , Borjian Mohammad Amin , Ayati Aryan , Zoroufian Arezou 
Published: April 2023

AbstractRight heart cement embolization is a rare but potentially life‐threatening complication of vertebroplasty surgeries. Transthoracic echocardiography is the first‐line imaging modality for detecting cement particles in cardiac chambers. Anticoagulation treatments or surgical interventions are necessary, depending on the patient's condition.
Hydatid cyst of the middle mediastinum complicated by fistulated ascending aorta: A case report and review of the literature
Authors: Mehri Ali , Esparham Ali , Tashnizi Mohammad Abbasi , Rezaei Reza 
Published: April 2023

AbstractClinicians must pay attention to the clinical presentation and consequences of hydatid cysts in rare sites. Cysts close to the aorta require planning and assistance of a cardiac or vascular surgeon before surgical intervention can be considered.
Occlusion of femoral artery using Foley catheter: A REBOA inspired tale to save a life
Authors: Papan Amir Mohammad , Husseinzade Mofid , Heydari Kamran , Hamidi Hossein 
Published: April 2023

AbstractIn this case report, we emphasized the need to control bleeding in emergency departments by any measure possible, as it is the first step toward successful resuscitation for saving the lives of patients with active bleeding.
Recurring desmoid tumor of the neck: A case report
Authors: Pribuišis Kipras , Vaidelys Lukas , Piluckis Julius , Padervinskis Evaldas , Vaitkus Saulius , Šarauskas Valdas 
Published: April 2023

AbstractThe infiltrative growth pattern of desmoid tumors and their proximity to important anatomical structures make them difficult to manage. Mutilating surgery should be avoided, while surveillance or radiotherapy remain valid options.
A Greener Pathway to Enantiopurity: Mechanochemical Deracemization through Abrasive Grinding
Authors: Lopes Chrystal , Cartigny Yohann , Brandel Clément , Dupray Valérie , Body Carole , Shemchuk Oleksii , Leyssens Tom 
Published: April 2023

AbstractWe report the first case of mechanochemical deracemization by using liquid‐assisted abrasive grinding. The target molecule is a precursor of Paclobutrazol, an important fungicide and plant growth inhibitor. Using mechanochemical deracemization, we are even able to transform a 10 % ee scalemic mixture of this latter in an enantioenriched product of 97 % ee in a couple of hours. This is substantially shorter compared to solution‐based deracemization methodologies. The present paper thus introduces an efficient and greener process to enantiopure material.
A Novel C Doped MoS2/CoP/MoO2 Ternary Heterostructure Nanoflower for Hydrogen Evolution Reaction at Wide pH Range and Efficient Overall Water Splitting in Alkaline Media
Authors: Wang Yan , Gao Shanshan , Jiang Yu , Song Xiaoming , Tang Guofeng , Zhang Xiangbin 
Published: April 2023

AbstractThe development of low‐cost and high‐efficiency bifunctional catalysts is still a challenge for hydrogen production through overall water splitting. This paper reports the in‐situ synthesis of C‐doped MoS2/CoP/MoO2 using bacterial cellulose (BC) as the reducing agent and the source of C and using BC (MoS2/Co1.2MoO4.2 ⋅ 1.2H2O/BC) as the template. Heterogeneous structure for hydrogen evolution reaction (HER) and alkaline water electrolysis in a wide pH range. Due to the large number of defect sites caused by C doping and the synergy between these three active components (MoS2, CoP and MoO2), the HER and oxygen evolution reaction (OER) activities of the catalyst have been greatly improved. Therefore, during HER, a small initial overpotential (27 mV) was achieved in 1.0 M KOH. In 0.5 M H2SO4, 0.1 M PBS and 1.0 M KOH, the current density reached 10 mA cm−2 at overpotentials of 123.4, 150, and 139 mV, respectively. For OER, an overpotential of 268 mV was required to achieve 10 mA cm−2. The alkaline two‐electrode device composed of C doped MoS2/CoP/MoO2 delivers 10 mA cm−2 at a low potential of 1.51 V and can be easily driven by a single AA battery. This work provides a new design strategy of C doped ternary heterostructures for electrocatalysis and related energy applications.
Synthesis and Structure‐Activity Relationship Studies of C(13)‐Desmethylene‐(−)‐Zampanolide Analogs
Authors: Brütsch Tobias M. , Cotter Etienne , Lucena‐Agell Daniel , Redondo‐Horcajo Mariano , Davies Carolina , Pfeiffer Bernhard , Pagani Sandro , Berardozzi Simone , Fernando Díaz J. , Miller John H. , Altmann Karl‐Heinz 
Published: April 2023

AbstractWe describe the synthesis and biochemical and cellular profiling of five partially reduced or demethylated analogs of the marine macrolide (−)‐zampanolide (ZMP). These analogs were derived from 13‐desmethylene‐(−)‐zampanolide (DM‐ZMP), which is an equally potent cancer cell growth inhibitor as ZMP. Key steps in the synthesis of all compounds were the formation of the dioxabicyclo[15.3.1]heneicosane core by an intramolecular HWE reaction (67–95 % yield) and a stereoselective aza‐aldol reaction with an (S)‐BINOL‐derived sorbamide transfer complex, to establish the C(20) stereocenter (24–71 % yield). As the sole exception, for the 5‐desmethyl macrocycle, ring‐closure relied on macrolactonization; however, elaboration of the macrocyclization product into the corresponding zampanolide analog was unsuccessful. All modifications led to reduced cellular activity and lowered microtubule‐binding affinity compared to DM‐ZMP, albeit to a different extent. For compounds incorporating the reactive enone moiety of ZMP, IC50 values for cancer cell growth inhibition varied between 5 and 133 nM, compared to 1–12 nM for DM‐ZMP. Reduction of the enone double bond led to a several hundred‐fold loss in growth inhibition. The cellular potency of 2,3‐dihydro‐13‐desmethylene zampanolide, as the most potent analog identified, remained within a ninefold range of that of DM‐ZMP.
Organoiridium Complexes Enhance Cellular Defense Against Reactive Aldehydes Species
Authors: Jana Rahul D. , Ngo Anh H. , Bose Sohini , Do Loi H. 
Published: April 2023

AbstractAlthough reactive aldehyde species (RASP) are associated with the pathogenesis of many major diseases, there are currently no clinically approved treatments for RASP overload. Conventional aldehyde detox agents are stoichiometric reactants that get consumed upon reacting with their biological targets, which limits their therapeutic efficiency. To achieve longer‐lasting detoxification effects, small‐molecule intracellular metal catalysts (SIMCats) were used to protect cells by converting RASP into non‐toxic alcohols. It was shown that SIMCats were significantly more effective in lowering cell death from the treatment with 4‐hydroxynon‐2‐enal than aldehyde scavengers over a 72 h period. Studies revealed that SIMCats reduced the aldehyde accumulation in cells exposed to the known RASP inducer arsenic trioxide. This work demonstrates that SIMCats offer unique benefits over stochiometric agents, potentially providing new ways to combat diseases with greater selectivity and efficiency than existing approaches.
An efficient energy consumption model using data aggregation for wireless sensor network
Authors: Sheena B. Gracelin , Snehalatha N. 
Published: April 2023

SummaryWireless sensor networks (WSNs) have become increasingly important in recent years. Small and low‐power sensor nodes make up these sensor networks. A random distribution of nodes is made throughout an unmanaged target region. One of WSN's key challenges is its limited and irreplaceable energy supply. In most situations, sensor nodes cannot be replaced since they operate in a hostile physical environment. The act of gathering and aggregating usable data from different sensor nodes situated to perceive almost the same attribute of the occurrence is known as data aggregation. The mathematical model is used in this research study to generate cluster‐based data aggregation, which is an effective technique to increase energy usage by minimising the number of data transfers. The proposed mathematical model‐based data aggregation (MM‐DA) attains a 97% packet delivery ratio with minimal energy consumption. The MM‐DA outperforms other existing approaches in terms of packet delivery ratio (PDR), energy consumption (EC), network lifetime and control overhead.
Factors associated with cognitive impairment in Latin American older adults: A cross‐sectional observational study of COVID‐19 confinement
Authors: Ramos‐Henderson Miguel , Soto‐Añari Marcio , Herrera‐Pino Jorge , Porto María F. , Camargo Loida , Hesse Heike , Ferrel‐Ortega † Robert , Quispe‐Ayala Cesar , García de la Cadena Claudia , Mendoza‐Ruvalcaba Neyda , Caldichoury Nicole , Castellanos Cesar , Varón Claudia , Aguilar Dolores , Antezana Regulo , Martinez Juan , Román Norbel , Boza Carolina , Ducassou Alejandro , Saldías Carol , López Norman 
Published: April 2023

AbstractINTRODUCTIONThe effects of COVID‐19 confinement have been severe, especially in older adults. Therefore, we analyzed the factors associated with cognitive impairment (CI) in Latin America (LA).METHODSWe conducted a cross‐sectional observational study with a total of 5245 older adults from 10 countries in LA.MeasurementWe used the Telephone Montreal Cognitive Assessment (T‐MoCA) and the Eight‐item Informant Interview to Differentiate Aging and Dementia (AD8) scale.RESULTSWe found that age, depressive symptomatology, bone fractures, being widowed, having a family member with dementia, and unemployment were associated with an increased risk of CI. In contrast, higher education, hypertension with continuous treatment, quarantine, and keeping stimulating cognitive and physical activities were associated with a lower probability of CI. No significant association was found between suffering from diabetes or being retired and CI.DISCUSSIONIt is essential to conduct follow‐up studies on these factors, considering their relationship with CI and the duration of confinement.
Detection time comparison of non‐hydrolysed sulphated metabolites of metenolone, mesterolone and 17α‐methyltestosterone analysed by four different mass spectrometric techniques
Authors: Albertsdóttir Aðalheiður Dóra , Van Gansbeke Wim , Van Eenoo Peter , Polet Michael 
Published: April 2023

AbstractThe frequent detection of anabolic androgenic steroids (AAS) indicates their popularity among rule‐breaking athletes. The so called long‐term metabolites play a crucial role in their detection, and non‐hydrolysed sulphated metabolites have gained renewed interest, as research has demonstrated their extended detection time compared to the more conventional markers (e.g., for metenolone and mesterolone). Their potential has been investigated using liquid and gas chromatography–mass spectrometry (LC‐ and GC‐MS). However, due to their complementary nature, chances are that the most promising metabolite on one technique does not necessarily exhibit the same behaviour on the other and vice versa. Therefore, a comparison was carried out where as a trial model, metenolone, mesterolone and 17α‐methyltestosterone were selected and the most likely long‐term sulphated metabolites identified on four mass spectrometric instruments. Additionally, using a modified sample preparation procedure, comparison between conventional and non‐hydrolysed sulphated metabolites between different GC‐MS instruments was also included. When focusing on each individual marker, no cases were observed where a single metabolite provided a superior detection time on all instruments. Furthermore, for each AAS, there were incidences where a metabolite provided the best detection time on one instrument but could only be detected for a shorter period or not at all on other instruments. This demonstrates that metabolite detection windows and hence their added‐value as target substance are unique and dependent on the analytical technique and not only on their pharmacokinetic behaviour. Consequently, in each case, a metabolite versus instrument evaluation is needed to maximise the probabilities of detecting doping offences.
Analysis of tetramisole metabolites – Is “Aminorex” found in forensic samples of cocaine users actually 4‐phenyl‐2‐imidazolidinone?
Authors: Hundertmark Marica , Hess Cornelius , Röhrich Jörg , Wunder Cora , Losacker Moritz 
Published: April 2023

AbstractPhenyltetrahydroimidazothiazole (PTHIT, tetramisole) is a common adulterant in cocaine samples. Little is known about its human metabolism. p‐hydroxy‐PTHIT has long been the only proven phase‐I‐metabolite. Another putative metabolite is the stimulant aminorex. However, data on its analytical proof is rare and contradictory. Even less known is its constitutional isomer 4‐phenyl‐2‐imidazolidinone which has only been proven in animal samples so far. The aim of the study was to get insight into the metabolism of PTHIT after controlled nasal uptake of PTHIT and in real forensic cocaine/benzoylecgonine‐positive samples.A liquid chromatography–tandem mass spectrometry (LC–MS/MS) method was validated for quantification of 4‐phenyl‐2‐imidazolidinone and p‐hydroxy‐PTHIT (LOQ 0.05 ng/ml each). Selectivity was ensured for 4‐phenyl‐2‐imidazolidinone and aminorex (LOD 0.05 ng/ml). After controlled nasal uptake of tetramisole (10 mg, n = 3) a shorter half‐life for p‐hydroxy‐PTHIT (3.4–5.8 h) was determined than for 4‐phenyl‐2‐imidazolidinone (14.0–15.9 h). p‐hydroxy‐PTHIT (33%) and 4‐phenyl‐2‐imidazolidinone (51%) were also detected in serum samples from cocaine users tested previously positive for PTHIT (n = 73). Aminorex was never detected.The potential of misinterpreting 4‐phenyl‐2‐imidazolidinone as aminorex was tested using a gas chromatography–mass spectrometry (GC–MS) method used in the literature and an in‐house liquid chromatography‐time‐of‐flight mass spectrometry (LC‐QTOF) screening‐method. Using GC–MS the analysed bis‐trimethylsilyl‐derivatives cannot be differentiated due to co‐elution. Both substances were chromatographically separated using the LC‐QTOF method, but library comparison workflows misinterpreted 4‐phenyl‐2‐imidazolidinone as aminorex.It seems likely that aminorex, which was allegedly identified as a metabolite of PTHIT in samples of cocaine users in previous studies, is in fact 4‐phenyl‐2‐imidazolidinone.
The promise of single‐session interventions to inform stepped care approaches for complex mental health problems: Commentary on Schleider et al. (2023)
Authors: Rizvi Shireen L. , Kleiman Evan M. 
Published: April 2023

AbstractSchleider et al. (2023, International Journal of Eating Disorders) provide an overview and compelling rationale for incorporating single‐session interventions (SSIs) into the eating disorder field. As intervention researchers working with complex mental health problems, including suicide risk, we agree that there is much to be gained by developing and deploying SSIs on a broader scale and for historically difficult‐to‐treat problems. In this commentary, we describe some additional strengths of the SSI approach and highlight their potential in the use of stepped care models of treatment. Ultimately, determining who could benefit from a low dose of treatment and for whom longer treatment is warranted could pave the way for addressing the current mental health burden.
Cardiac and kidney benefits of empagliflozin in heart failure across the spectrum of kidney function: Insights from the EMPEROR‐Preserved trial
Authors: Sharma Abhinav , Ferreira João Pedro , Zannad Faiez , Pocock Stuart J. , Filippatos Gerasimos , Pfarr Egon , Petrini Michaela , Kraus Bettina J. , Wanner Christoph , Packer Milton , Butler Javed , Anker Stefan D. 
Published: April 2023

AbstractAimIn the EMPEROR‐Preserved trial, empagliflozin improved clinical outcomes of patients with heart failure (HF) with preserved ejection fraction. In this pre‐specified analysis, we aim to study the effect of empagliflozin on cardiovascular and kidney outcomes across the spectrum of kidney function.Methods and resultsPatients were categorized by the presence or absence of chronic kidney disease (CKD) at baseline (CKD defined by an estimated glomerular filtration rate [eGFR] <60 ml/min/1.73 m2 or urine albumin to creatinine ratio >300 mg/g). The primary and key secondary outcomes were (i) a composite of cardiovascular death or first HF hospitalization (primary outcome); (ii) total number of HF hospitalization, (iii) eGFR slope; and a pre‐specified exploratory composite kidney outcome including a sustained ≥40% decline in eGFR, chronic dialysis or renal transplant. The median follow‐up was 26.2 months. A total of 5988 patients were randomized to empagliflozin or placebo, of whom 3198 (53.5%) had CKD. Irrespective of CKD status, empagliflozin reduced the primary outcome (with CKD: hazard ratio [HR] 0.80, 95% confidence interval [CI] 0.69–0.94; without CKD: HR 0.75, 95% CI 0.60–0.95; interaction p = 0.67) and total (first and recurrent) hospitalizations for HF (with CKD: HR 0.68, 95% CI 0.54–0.86; without CKD: HR 0.89, 95% CI 0.66–1.21; interaction p = 0.17). Empagliflozin slowed the slope of eGFR decline by 1.43 (1.01–1.85) ml/min/1.73 m2/year in patients with CKD and 1.31 (0.88–1.74) ml/min/1.73 m2/year in patients without CKD (interaction p = 0.70). Empagliflozin did not reduce the pre‐specified kidney outcome in patients with or without CKD (with CKD: HR 0.97, 95% CI 0.71–1.34; without CKD: HR 0.92, 95% CI 0.58–1.48; interaction p = 0.86) but slowed progression to macroalbuminuria and reduced the risk of acute kidney injury. The effect of empagliflozin on the primary composite outcome and the key secondary outcomes was consistent across five baseline eGFR categories (all interaction p >0.05). Empagliflozin was well tolerated independent of CKD status.ConclusionsIn EMPEROR‐Preserved, empagliflozin had a beneficial effect on the key efficacy outcomes in patients with and without CKD. Overall, the benefit and safety of empagliflozin was consistent across a wide range of kidney function spectrum, down to a baseline eGFR of 20 ml/min/1.73 m2.
Decreased serum concentrations of antiseizure medications in children with drug resistant epilepsy following treatment with ketogenic diet
Authors: Pedersen Sigrid , Kverneland Magnhild , Rudi Knut , Gervin Kristina , Landmark Cecilie Johannessen , Iversen Per Ole , Selmer Kaja Kristine 
Published: April 2023

AbstractObjectiveTo examine the potential influence of a ketogenic diet on serum concentrations of antiseizure medications (ASMs) in children with drug resistant epilepsy.MethodsWe investigated the serum concentrations of ASMs in 25 children with drug resistant epilepsy, 2–13 years of age, treated with a classical ketogenic diet for 12 weeks. The patients were recruited from the National Centre for Epilepsy from August 15th, 2017, to January 24th, 2022. Changes in ASM serum concentrations were analyzed using a mixed effect model analysis. Significance level was set at P < 0.05 for all comparisons.ResultsThe participants used 12 different ASMs during the study. The mean number of ASMs was 2.4 (±SD 0.7). None of the participants changed the type or dose of the ASMs during the intervention period. The serum concentrations of clobazam (n = 9, P = 0.002), desmethylclobazam (n = 9, P = 0.010), and lamotrigine (n = 6, P = 0.016) decreased significantly during the dietary treatment. The analytes with the largest reduction in serum concentration after 12 weeks of dietary treatment were clobazam (mean change −38%) and desmethylclobazam (mean change −37%). We found no significant change in the serum concentrations of levetiracetam, topiramate, and valproic acid.SignificanceWe identified a significant decrease in the serum concentrations of clobazam, desmethylclobazam, and lamotrigine following a 12‐week ketogenic diet intervention in children with drug resistant epilepsy. An unintended decrease in the serum concentrations of ASMs may render the patient prone to seizures. Measurements of ASM serum concentrations might be useful in patients on a ketogenic diet, especially in patients with lack of efficacy of the dietary treatment.