bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phase transformation induced fatigue of a Ce‐TZP/Al2O3 composite
Authors: Cheng Yung‐Shin , Chen Yu‐Xin , Tuan Wei‐Hsing , Chen Jin‐Ren , Lai Po‐Liang 
Published: August 2023

AbstractIn this study, the stress–cycle number (S–N curve) of a composite consisting of ceria‐stabilized zirconia (Ce‐TZP) and alumina (Al2O3) was measured. First, the initial bending strength of the Ce‐TZP/Al2O3 composite was determined using a four‐point bending technique. Next, stress above 70% of the initial bending strength was applied on the composite for up to 1,000,000 cycles. Transformation bands were formed on the tensile surface in the first several cycles as the stress was higher than a critical value. The number and width of bands then changed marginally after their fomraiton. Fatigue failure occured at the band with the largest width, as a result of slow crack growth process. The transformation bands could be removed using a post‐fatigue heating treatment. After removal of these bands, the strength was consequently enhanced.
Clinical and histologic findings after use of a novel combined retinol, tripeptide, and glaucine containing cream in the treatment of photo‐aged skin
Authors: Rao Shikha , Goldberg David 
Published: August 2023

AbstractBackgroundNeck skin is thinner and has a more delicate dermal layer than facial skin. The studied product was specifically formulated for the neck combining a hydrating delivery system with a trifunctional corrective technology composed of 0.2% pure retinol, 2.5% tripeptide concentrate, and 5.0% glaucine complex to help improvement in signs of aging.ObjectivesTo evaluate cosmetic and histologic changes 3 months after treatment using immunostains for Type I collagen, Type III collagen, and glycosaminoglycan (GAGS). In addition, overall clinical improvement in photoaged skin was measured by both Griffith's photonumeric photoaging scale, photographic improvement, and questionnaires.MethodsThis study was an open‐label, blinded clinical trial evaluating a combined retinol, tripeptide, and glaucine containing cream in the treatment of photo‐aged skin. The study enrolled a total of 20 healthy male or female subjects, who applied the product for 3 months to their face and neck.ResultsClinical as well histologic changes were consistent with improvement in all 20 subjects.ConclusionUse of a combined retinol, tripeptide, and glaucine containing cream led to both clinical and histologic improvement of phototoaging.
Accuracy of torque controllers on healing abutments in implant dentistry—an in vitro study
Authors: Goyal Varun , Delgado‐Ruiz Rafael , Kurtz Kenneth S. , Romanos Georgios E. 
Published: August 2023

AbstractPurposeTo evaluate the accuracy of three torque‐control devices used on healing abutments in implant prosthodontics.Materials and MethodsIn this in vitro experiment, three torque controllers, Ankylos friction‐based, Straumann spring‐based, and Anthogyr pre‐calibrated torque control devices were used to tighten the healing abutments of Ankylos and Straumann dental implants to a pre‐determined value of 15 Ncm. A digital torque meter (DT), Cedar DID‐4A, was used to assess removal torque as a surrogate for the accuracy of the torque controllers to apply a tightening force of 15 Ncm on healing abutments. One‐way analysis of variance (ANOVA) was used to identify differences between each torque controller and the digital torquemeter, a p < 0.05 was considered significant.ResultsThe torque required to remove the healing abutments was 16.05 ± 0.66 Ncm for the Ankylos ratchet, 12.61 ± 0.90 Ncm for the Straumann ratchet, and 14.37 ± 1.08 Ncm for the Anthogyr torque‐control device. Significant statistical differences were observed between Ankylos and the control digital torquemeter (p = 1.84E−8; F = 50.3); Anthogyr and control digital torquemeter (p = 0.01; F = 6.79); and Straumann and control digital torquemeter (p = 0.01; F = 141.15).ConclusionFriction‐based (Ankylos), spring‐based (Straumann), and pre‐calibrated (Anthogyr) torque control devices present over‐torque and under‐torque values when used over healing abutments of Ankylos and Straumann implant systems.
The experience of eating for older nursing home residents with dysphagia: A qualitative descriptive study
Authors: Hsu Wen‐Ching , Tsai Hsiu‐Hsin , Weng Li‐Cheng , Wang Yi‐Wen 
Published: August 2023

AbstractBackgroundUnderstanding the experience of eating for nursing home residents with dysphagia is essential for developing effective and holistic compensatory intervention programmes for older adults with dysphagia. However, there is a lack of studies on the experience of eating for older adults with dysphagia, especially for individuals in Asian cultures.ObjectivesThis study aimed to understand the experience of eating for older nursing home residents who have difficulty swallowing (dysphagia), which is often a problem for this population.MethodsThis qualitative descriptive study recruited older nursing home residents with dysphagia from facilities in central Taiwan. Residents were recruited by purposive sampling. Data were collected through individual in‐depth semistructured face‐to‐face interviews. Interviews were audio‐recorded and transcribed interview data were analysed with content analysis.ResultsA total of 20 residents participated in the study; the mean age was 78.7 years (standard deviation = 8.54 years); male and female residents were equally represented. The main core theme describing the experience of eating for nursing home residents with dysphagia was irregular coughing, which often occurred spontaneously. Three subthemes described how residents responded: making adjustments to eating and swallowing, receiving assistance from NH staff and fear of eating.ConclusionsOur findings can serve as an evidence‐based reference for clinical care aimed at nursing home residents with dysphagia. Support programmes that provide safe swallowing skills and emotional support for managing dysphagia are recommended.Implications for practiceNursing home residents with dysphagia should receive interventions focussed on self‐supporting care, training in swallowing skills and emotional support.
Functional characterization and structural basis of a reversible glycosyltransferase involves in plant chemical defence
Authors: Cheng Weijia , Fang Xueting , Guan Zhifeng , Yao Yan , Xu Zhenni , Bi Yunya , Ren Kexin , Li Jiwen , Chen Fangfang , Chen Xiangsong , Ma Weihua , Chu Zhaohui , Deng Zixin , Zhang Zhengyu , Lu Li 
Published: August 2023

SummaryPlants experience numerous biotic stresses throughout their lifespan, such as pathogens and pests, which can substantially affect crop production. In response, plants have evolved various metabolites that help them withstand these stresses. Here, we show that two specialized metabolites in the herbaceous perennial Belamcanda chinensis, tectorigenin and its glycoside tectoridin, have diverse defensive effects against phytopathogenic microorganisms and antifeeding effects against insect pest. We further functionally characterized a 7‐O‐uridine diphosphate glycosyltransferase Bc7OUGT, which catalyses a novel reversible glycosylation of tectorigenin and tectoridin. To elucidate the catalytic mechanisms of Bc7OUGT, we solved its crystal structure in complex with UDP and UDP/tectorigenin respectively. Structural analysis revealed the Bc7OUGT possesses a narrow but novel substrate‐binding pocket made up by plentiful aromatic residues. Further structure‐guided mutagenesis of these residues increased both glycosylation and deglycosylation activities. The catalytic reversibility of Bc7OUGT was also successfully applied in an one‐pot aglycon exchange reaction. Our findings demonstrated the promising biopesticide activity of tectorigenin and its glycosides, and the characterization and mechanistic study of Bc7OUGT could facilitate the design of novel reversible UGTs to produce valuable glycosides with health benefits for both plants and humans.
The limits of the just‐too‐different argument
Authors: Francén Ragnar , Moberger Victor 
Published: August 2023

AbstractAccording to moral non‐naturalism, the kind of genuine or robust normativity that is characteristic of moral requirements cannot be accounted for within a wholly naturalistic worldview, but requires us to posit a domain of non‐natural properties and facts. The main argument for this core non‐naturalist claim appeals to what David Enoch calls the ‘just‐too‐different intuition’. According to Enoch, robust normativity cannot be natural, since it is just too different from anything natural. Derek Parfit makes essentially the same claim under the heading of ‘the normativity objection’, and several other non‐naturalists have said similar things. While some naturalists may be tempted to reject this argument as methodologically or dialectically illegitimate, we argue instead that there are important limits to what the just‐too‐different intuition can show, even setting all other worries aside. More specifically, we argue that the just‐too‐different argument will backfire on any positive, independent specification of the distinction between the natural and the non‐natural. The upshot is that the just‐too‐different argument can show significantly less than non‐naturalists have suggested.
The cosmological ideas in Kant's critical philosophy: Their unique status and twofold regulative use
Authors: Howard Stephen 
Published: August 2023

AbstractKant's theory of the regulative use of ideas of reason has been clarified considerably in recent scholarship. Little attention has been paid, however, to the question of whether the three classes of transcendental ideas—psychological, cosmological, and theological—may differ with regard to their regulative use. This article argues that there is a fundamental difference between the classes of ideas in this respect and that an examination of this heterogeneity can provide much‐needed insight into Kant's account of the utility of the cosmological ideas. First, I set out Kant's distinction between the cosmological ideas and their psychological and theological counterparts. Second, I clarify the two distinct regulative uses of each cosmological idea. I argue that the two opposed sides of the cosmological antinomies provide two different heuristic functions, aligned with the theoretical and practical interests of reason.
Risk factors associated with pressure ulcer recurrence after reconstruction: Analysis of a national database
Authors: McCranie Alec S. , Constantine Ryan S. , Lee Nayun , Le Elliot L. H. , Gehring Michael , Iorio Matthew L. 
Published: August 2023

AbstractIn this study, we sought to clarify the patient traits and comorbidities that are associated with pressure injury recurrence following pressure injury reconstruction. An insurance claims database, PearlDiver, was used to conduct a retrospective cohort study. The two cohorts included patients who underwent pressure injury reconstruction without recurrence and patients who experienced recurrence with subsequent reconstruction. Multiple logistic regression analysis was used to identify risk factors for recurrence after reconstruction. Recurrence was associated with hypoalbuminemia (p < 0.05), paraplegia (p < 0.05), and osteomyelitis (p < 0.05). In patients with osteomyelitis, primary closure was associated with recurrence (p < 0.05) while flap reconstruction was not (p > 0.05). Osteomyelitis was not associated with recurrence after flap reconstruction. Prior to reconstruction, patients with osteomyelitis and hypoalbuminemia should have their nutrition and infection optimised.
Crystallographic Helly groups
Authors: Hoda Nima 
Published: August 2023

AbstractWe prove that asymptotic cones of Helly graphs are countably hyperconvex. We use this to show that virtually nilpotent Helly groups are virtually abelian and to characterize virtually abelian Helly groups via their point groups. In fact, we do this for the more general class of coarsely injective spaces and groups. We apply this to prove that the 3‐3‐3‐Coxeter group is not Helly (nor even coarsely injective), thus obtaining the first example of a systolic group that is not Helly, answering a question of Chalopin, Chepoi, Genevois, Hirai, and Osajda.
New Insights Into Accelerometer-Measured Habitual Physical Activity and Sedentary Time During Early Recovery in Pediatric Concussion
Authors: Sharma Bhanu , Obeid Joyce , DeMatteo Carol , Noseworthy Michael D. , Timmons Brian W. 
Published: August 2023

Purpose: Concussion management is shifting away from a rest-is-best approach, as data now suggest that exercise-is-medicine for this mild brain injury. Despite this, we have limited data on habitual physical activity following concussion. Therefore, our objective was to quantify accelerometer-measured physical activity and sedentary time in children with concussion (within the first month of injury) and healthy controls. We hypothesized that children with concussion would be less active than their healthy peers. Methods: We performed a secondary analysis of prospectively collected accelerometer data. Our sample included children with concussion (n = 60, 31 females) and historical controls (n = 60) matched for age, sex, and season of accelerometer wear. Results: Children with concussion were significantly more sedentary than controls (mean difference [MD], 38.3 min/d, P = .006), and spent less time performing light physical activity (MD, −19.5 min/d, P = .008), moderate physical activity (MD, −9.8 min/d, P < .001), and vigorous physical activity (MD, −12.0 min/d, P < .001); these differences were observed from 8:00 AM to 9:00 PM. Sex-specific analyses identified that girls with concussion were less active and more sedentary than both boys with concussion (P = .010) and healthy girls (P < .010). Conclusion: There is an activity deficit observed within the first month of pediatric concussion. Physical activity guidelines should address this while considering sex effects.
Complete genome sequence of
Roseinatronobacter
sp. strain S2, a chemolithoheterotroph isolated from a pH 12 serpentinizing system
Authors: Trutschel Leah R. , Rowe Annette R. , Sackett Joshua D. 
Published: August 2023

ABSTRACT

Here, we report the complete genome sequence for
Roseinatronobacter
sp. S2, a sulfur-oxidizing heterotroph isolated from a serpentinizing system in Northern California. The S2 genome is 4.4 Mb and contains 4,570 protein-encoding genes. This organism contains the genes necessary for sulfur species oxidation and complete ethylmalonyl and pentose phosphate pathways.
Suicidal thoughts and behaviours among military veterans: protocol for a prospective, observational, neuroimaging study
Authors: Namaky Nauder , Swearingen Hannah R , Winter Jake , Bozzay Melanie , Primack Jennifer M , Philip Noah S , Barredo Jennifer 
Published: August 2023

IntroductionThis study’s overarching goal is to examine the relationship between brain circuits and suicidal thoughts and behaviours (STBs) in a transdiagnostic sample of US military veterans. Because STBs have been linked with maladaptive decision-making and disorders linked to impulsivity, this investigation focuses on valence and inhibitory control circuits.Methods and analysisIn this prospective, observational study, we will collect functional MRI (fMRI), cognitive and clinical data from 136 veterans (target sample size) recruited from the Providence VA Health System (PVAHS): 68 with STBs and 68 matched controls. Behavioural data will be collected using standardised measures of STBs, psychiatric symptoms, cognition, functioning and medical history. Neuroimaging data will include structural, task and resting fMRI. We will conduct follow-up interviews and assessments at 6, 12 and 24 months post-enrolment. Primary analyses will compare data from veterans with and without STBs and will also evaluate whether activation and connectivity within circuits of valence and inhibition covary with historical and prospective patterns of suicidal ideation and behaviour.Ethics and disseminationThe PVAHS Institutional Review Board approved this study (2018–051). Written informed consent will be obtained from all participants. Findings from this study will be published in peer-reviewed journals and presented at local, regional, national and international conferences.Nauder Namaky, Ph.D.* nauder_namaky@brown.edu
Paediatric organ donation following neurological determinants of death in intensive care units in Saudi Arabia: a retrospective cross-sectional study
Authors: Kazzaz Yasser Mohammed , Maghrabi Fidaa , Alkhathaami Raghad Ali , Alghannam Rahaf Fahad , Alonazi Nora Mohammad , Alrubaiaan Alanood Abdullah , Alkadeeb Nayla Anwar , Antar Mohannad , Babakr Razan 
Published: August 2023

ObjectivesThe aim of this retrospective cross-sectional study was to assess the performance of paediatric organ donation in intensive care units following neurological determinants of death in Saudi Arabia.DesignRetrospective cross-sectional study.SettingPaediatric intensive care units at three tertiary centres over 5 years.Participants423 paediatric deaths (<14 years) from January 2017 to December 2021.Primary outcomePatients were identified as either possible, potential, eligible, approached, consented or actual donors based on organ donation definitions from the WHO, Transplantation Society and UK potential donor audit.Secondary outcomeSecondary outcome was causative mechanisms of brain injury in possible donors. Demographics of the study cohort (age, sex, hospital length of stay (LOS), paediatric intensive care unit LOS, pre-existing comorbidities, admission type and diagnosis category) were compared between possible and non-possible donors. Demographics were also compared between patients who underwent neurological determination of death and patients who did not.ResultsAmong the 423 paediatric deaths, 125 (29.6%) were identified as possible donors by neurological criteria (devastating brain insult with likelihood of brain death, Glasgow Coma Score of 3 and ≥2 absent brainstem reflexes). Of them, 41 (32.8%) patients were identified as potential donors (neurological determination of death examinations initiated by the treating team), while only two became actual donors. The eligible death conversion rate was 6.9%. The reporting rate to organ procurement organisation was 70.7% with a consent rate of 8.3%. The most common causes of brain insult causing death were cardiac arrest (44 of 125 patients, 35.2%), followed by traumatic brain injury and drowning (31 of 125 patients, 24.8%), and intracranial bleeding (13 of 125 patients, 11.4%).ConclusionMajor contributors to low actual donation rate were consent, donor identification and donor referral.
Exploring barriers to living donor kidney transplant for African, Caribbean and Black communities in the Greater Toronto Area, Ontario: a qualitative study protocol
Authors: Edwards Beth , Marshall Lydia-Joi , Ahmadzadeh Ghazaleh , Ahmed Ranie , Angarso Lydia , Balaji Shilpa , Okoh Princess , Rogers Emma , Neves Paula , Boakye Priscilla , Gill Jagbir , James Carl Everton , Mucsi Istvan 
Published: August 2023

IntroductionLiving donor (LD) kidney transplant (KT) is the best treatment option for many patients with kidney failure as it improves quality of life and survival compared with dialysis and deceased donor KT. Unfortunately, LDKT is underused, especially among groups marginalised by race and ethnicity. African, Caribbean and Black (ACB) patients are 60%–70% less likely to receive LDKT in Canada compared with white patients. Research from the USA and the UK suggests that mistrust, cultural and generational norms, access, and affordability may contribute to inequities. To date, no Canadian studies have explored the beliefs and behaviours related to LDKT in ACB communities. Research approaches that use a critical, community-based approach can help illuminate broader structural factors that may shape individual beliefs and behaviours. In this qualitative study, we will investigate barriers to accessing LDKT in ACB communities in the Greater Toronto Area, to enhance our understanding of the perspectives and experiences of ACB community members, both with and without lived experience of chronic kidney disease (CKD).Methods and analysisHospital-based and community-based recruitment strategies will be used to recruit participants for focus groups and individual interviews. Participants will include self-identified ACB individuals with and without experiences of CKD and nephrology professionals. Collaboration with ACB community partners will facilitate a community-based research approach. Data will be analysed using reflexive thematic analysis and critical race theory. Findings will be revised based on feedback from ACB community partners.Ethics and disseminationThis study has been approved by the University Health Network Research Ethics Board UHN REB file #15-9775. Study findings will contribute to the codevelopment of culturally safe and responsive educational materials to raise awareness about CKD and its treatments and to improve equitable access to high-quality kidney care, including LDKT, for ACB patients.
KLF12 overcomes anti-PD-1 resistance by reducing galectin-1 in cancer cells
Authors: Zheng Yujia , Zhang Hao , Xiao Chu , Deng Ziqin , Fan Tao , Zheng Bo , Li Chunxiang , He Jie 
Published: August 2023

BackgroundsImmune checkpoint blockade has revolutionized cancer treatment and has improved the survival of a subset of patients with cancer. However, numerous patients do not benefit from immunotherapy, and treatment resistance is a major challenge. Krüppel-like factor 12 (KLF12) is a transcriptional inhibitor whose role in tumor immunity is unclear.MethodsWe demonstrated a relationship between KLF12 and CD8+T cells in vivo and in vitro by flow cytometry. The role and underlying mechanism that KLF12 regulates CD8+T cells were investigated using reverse transcription and quantitative PCR, western blot FACS, chromatin immunoprecipitation-PCR and Dual-Luciferase reporter assays, etc, and employing small interfering RNA (siRNA) and inhibitors. In vivo efficacy studies were conducted with multiple mouse tumor models, employing anti-programmed cell death protein 1 combined with KLF12 or galectin-1 (Gal-1) inhibitor.ResultsHere, we found that the expression of tumor KLF12 correlates with immunotherapy resistance. KLF12 suppresses CD8+T cells infiltration and function in vitro and in vivo. Mechanistically, KLF12 inhibits the expression of Gal-1 by binding with its promoter, thereby improving the infiltration and function of CD8+T cells, which plays a vital role in cancer immunotherapy.ConclusionsThis work identifies a novel pathway regulating CD8+T-cell intratumoral infiltration, and targeting the KLF12/Gal-1 axis may serve as a novel therapeutic target for patients with immunotherapy resistance.