bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sports-Related Health Problems in Para-Sports: A Systematic Review With Quality Assessment
Authors: Luijten Sietske C.M. , te Loo Leonie M. , Nauta Joske , Janssen Thomas W.J. , Holla Jasmijn F.M. , Otten René H.J. , Vriend Ingrid , Verhagen Evert 
Published: June 2023

Context:Participation in sports is associated with a risk of sports-related health problems. For athletes with an impairment, sports-related health problems further burden an already restricted lifestyle, underlining the importance of prevention strategies in para-sports.Objective:To provide a comprehensive overview with quality assessment of the literature on sports-related health problems, their etiology, and available preventive measures in para-sports following the steps of the Sequence of Prevention.Data Sources:A literature search (in PubMed, Embase, SPORTDiscus, CINAHL and the Cochrane Library) was performed up to December 8, 2021, in collaboration with a medical information specialist.Study Selection:The search yielded 3006 articles, of which 64 met all inclusion criteria.Study Design:Systematic review with quality assessment.Level of Evidence:Level 3.Data Extraction:Two independent researchers carried out the screening process and quality assessment. One researcher extracted data, and the Sequence of Prevention categorized evidence.Results:A total of 64 studies were included, of which 61 reported on the magnitude and risk factors of sports-related health problems, while only 3 reported on the effectiveness of preventive measures. Of these, 30 studies were of high quality. Most studies (84%) included elite-level athletes. The reported injury incidence varied widely between sports (0-91 per 1000 athlete days) and impairment categories (1-50 per 1000 athlete days). The same applies to illness incidence with regard to different sports (3-49 per 1000 athlete days) and impairment categories (6-14 per 1000 athlete days).Conclusion:This review shows the current vast range of reported sport-related health problems in para-sports. There is limited evidence concerning the severity of these sports-related health problems and inconclusive evidence on the risk factors. Lastly, the evidence regarding the development and effectiveness of preventive measures for para-athletes is sparse.
Prolonged Transient Global Amnesia: Part of the Clinical Spectrum or a Separate Disease Entity?
Authors: Yong Heather Y.F. , Camara-Lemarroy Carlos R. 
Published: June 2023

Background Transient global amnesia (TGA) is the prototypical neurologic disease for acute-onset reversible amnesia. It is currently defined by resolution of symptoms within 24-hours. In this case report we describe an atypical case of prolonged TGA, emphasizing our current lack of knowledge surrounding this disease entity and its pathophysiology. Results A 66-year old female presented acutely with profound anterograde amnesia and variable retrograde amnesia with no inciting event. A thorough workup to exclude alternative causes of amnesia (including computed tomography angiogram and electroencephalogram) was normal. Her magnetic resonance imaging was consistent with TGA, with punctate diffusion restriction changes bilaterally in the hippocampi. She was also mildly hypoxemic with no discernible cause. She was ultimately diagnosed with TGA although her diagnosis remains controversial as her symptoms persisted for 72-hours. Conclusion Our patients clinical and imaging features (apart from her protracted time-course and hypoxemia) were in keeping with a diagnosis of TGA. The association of hypoxemia, COVID-19, obstructive sleep apnea, and the development of TGA remains to be elucidated. Although the underlying pathophysiology for TGA is unknown several mechanisms have been postulated including cortical spreading depression and reversible hypoxic-ischemic injury. The time course for symptom resolution, could be an important clue in discerning the pathophysiology of TGA on an individual basis. Importantly, a clinician should not be deterred by amnestic symptoms lasting >24-hours, if the patients clinical/radiologic presentation is consistent with TGA.
Effectiveness of medication review services on diabetes self-care in primary care patients-A randomised controlled study
Authors: Tay Sarah Siew Cheng , Lim Christina Jit Fan , Tan Daphne Soo Chieng , Tan Maureen Seok Yee , Chen Jieying , Oh Wan Lin , Khoo Shu Yuen , Goh Boon Kwang , Tang Woh Peng , Goh Bandy Qiuling 
Published: June 2023

Background Though self-care is a critical component of diabetes management, it is unknown whether pharmacist-run medication review service (MRS) can be an additional intervention to enhance self-care in diabetic patients. Objectives Hence, this study aims to determine the effectiveness of MRS in addition to existing care protocol in improving self-care in diabetic patients. Methods This randomised controlled study was conducted in five polyclinics from December 2014 to October 2016. Participants were 40 to 80 years of age and had been diagnosed with type 2 diabetes. These participants were prescribed with five or more chronic medications, of which at least one was an antidiabetic medication, by the primary healthcare centres’ doctors. The participants were randomly recruited into the intervention or control arm. A self-developed questionnaire which incorporated the validated Diabetes Self-Management Questionnaire (DSMQ) was administered face-to-face by the study team to the participants prior to and after MRS. MRS was not administered to participants in the control group. Results A total of 221 participants completed the follow up. There were 105 participants in the control arm and 116 in the intervention arm. The DSMQ Sum Scale score of the control group improved by 0.16 ± 1.11 ( p = 0.136) while the intervention group improved by 0.40 ± 0.99 ( p = 0.000). Participants in the intervention group reported a better improvement in their self-care of diabetes, specifically in glucose management ( p = 0.003), dietary control ( p = 0.096) and physical activity ( p = 0.003). Conclusions Pharmacist-run MRS can be included in addition to existing care to improve self-care in patients with diabetes.
Developing an eMental health monitoring module for older mourners using fuzzy cognitive maps
Authors: Brandl Lena , van Velsen Lex , Brodbeck Jeannette , Jacinto Sofia , Hofs Dennis , Heylen Dirk 
Published: June 2023

Objective Effective internet interventions often combine online self-help with regular professional guidance. In the absence of regularly scheduled contact with a professional, the internet intervention should refer users to professional human care if their condition deteriorates. The current article presents a monitoring module to recommend proactively seeking offline support in an eMental health service to aid older mourners. Method The module consists of two components: a user profile that collects relevant information about the user from the application, enabling the second component, a fuzzy cognitive map (FCM) decision-making algorithm that detects risk situations and to recommend the user to seek offline support, whenever advisable. In this article, we show how we configured the FCM with the help of eight clinical psychologists and we investigate the utility of the resulting decision tool using four fictitious scenarios. Results The current FCM algorithm succeeds in detecting unambiguous risk situations, as well as unambiguously safe situations, but it has more difficulty classifying borderline cases correctly. Based on recommendations from the participants and an analysis of the algorithm's erroneous classifications, we propose how the current FCM algorithm can be further improved. Conclusion The configuration of FCMs does not necessarily demand large amounts of privacy-sensitive data and their decisions are scrutable. Thus, they hold great potential for automatic decision-making algorithms in mental eHealth. Nevertheless, we conclude that there is a need for clear guidelines and best practices for developing FCMs, specifically for eMental health.
Impact of an Observation Medicine Educational Intervention on Residents’ Confidence, Knowledge, and Attitudes: A Quasi-Experimental Study
Authors: Sabir Riffat , Umar Muhammad , Medarametla Venkatrao , Sreedhrala Aseesh 
Published: June 2023

OBJECTIVES Driven by innovations in healthcare, observation medicine (OM) is expanding as a medical specialty. Despite exponential growth, education on OM remains underemphasized in the internal medicine (IM) residency programs. We assessed the impact of an educational intervention pairing didactic and experiential learning with an interdepartmental approach on IM residents’ confidence, knowledge, and attitudes when providing observation care to patients with neuro-cardiovascular diseases in the hospital setting. METHODS Our multifaceted intervention incorporated OM’s principles and practice in a flipped classroom with the team-, case-, lecture- and evidence-based learning model. Kirkpatrick’s evaluation model was used to assess the educational intervention’s effectiveness according to the first three levels, ie, reaction, learning, and behavior, using quantitative surveys. The surveys were completed pre-intervention, and immediately upon completion of the educational intervention. RESULTS Of 55 eligible residents, 55 (100%) participated in this intervention. Fifty (90%) completed the pre-intervention survey, and 21 (38%) completed the immediate post-intervention survey. Kirkpatrick’s evaluation framework showed that the intervention had a positive impact on residents’ motivational reaction ( attention, relevance, confidence, and satisfaction [ARCS], M = 3.8, SD = 0.87), their knowledge of common observation diagnoses (pre = 49%, post = 63%), particularly on cardiac diagnostic workup and approach to patients with transient neurological symptoms ( P < .05), and their behavior and self-assessment of core competency domains (pre-mean = 2.69, post-mean = 3.18, P < .001). CONCLUSIONS Our multimodal intervention provides a framework for a structured OM educational experience that can be incorporated into residency training, even without a formal observation unit rotation. The analysis also offers literary data on the current state of OM education in an IM residency program and supports the need to expand OM's educational resources to counteract the growth in hospital observation services. Future research should include an analysis of residents’ knowledge and skills from a longitudinal OM experience and advancing the results to residency programs where observation care is as applicable as ours.
Geographical origin classification of Phoebe zhennan and Phoebe bournei by solid phase micro-extraction and gas chromatography-mass spectrometry
Authors: Chen Zhenan , Xue Xiaoming , Cheng Ruoyi , Wu Haoqi , Gao Handng , Gao Zexun 
Published: June 2023

AbstractPhoebe zhennan and Phoebe bournei are favored for their fine-grain, insect resistance, special fragrance, not easily cracked and deformed, which had been widely used in furniture and construction. Wood authenticity regarding different varieties and geographical origins is increasingly becoming a concern for consumers. Due to the difference in wood quality characteristics and economic value of genus Phoebe species from different geographical origins, it is important to establish a fast, efficient, and reliable method to discriminate the geographical origin of Phoebe zhennan and Phoebe bournei. Solid phase micro-extraction (SPME) was used as sample preparation approach and gas chromatography-mass spectrometry (GC–MS) technique was employed to analyze the volatile compounds. As a result, a total of 40 volatiles were identified by SPME–GC–MS among Phoebe zhennan samples from four origins, while 34 substances identified among Phoebe bournei samples. The wood samples of Phoebe zhennan and Phoebe bournei from different major production areas in China were able be discriminated by GC–MS spectroscopy. This finding indicated that genus Phoebe species from different climate zones had different chemical composition, which verified that the SPME–GC–MS technique can be used to classify different species of wood with characteristic compounds.
BeEM: fast and faithful conversion of mmCIF format structure files to PDB format
Authors: Zhang Chengxin 
Published: June 2023

Abstract
Background
Although mmCIF is the current official format for deposition of protein and nucleic acid structures to the protein data bank (PDB) database, the legacy PDB format is still the primary supported format for many structural bioinformatics tools. Therefore, reliable software to convert mmCIF structure files to PDB files is needed. Unfortunately, existing conversion programs fail to correctly convert many mmCIF files, especially those with many atoms and/or long chain identifies.

Results
This study proposed BeEM, which converts any mmCIF format structure files to PDB format. BeEM conversion faithfully retains all atomic and chain information, including chain IDs with more than 2 characters, which are not supported by any existing mmCIF to PDB converters. The conversion speed of BeEM is at least ten times faster than existing converters such as MAXIT and Phenix. Part of the reason for the speed improvement is the avoidance of conversion between numerical values and text strings.

Conclusion
BeEM is a fast and accurate tool for mmCIF-to-PDB format conversion, which is a common procedure in structural biology. The source code is available under the BSD licence at https://github.com/kad-ecoli/BeEM/.
Investigation of KIR/HLA relationship and other clinical variables after T-cell-replete haploidentical bone marrow transplantation in patients with acute myeloid leukemia (AML)
Authors: Bakhtiari Tahereh , Ahmadvand Mohammad , Yaghmaie Marjan , Sadeghi Alireza , Mousavi Seied Asadollah , Rostami Tahereh , Ganjalikhani-Hakemi Mazdak 
Published: June 2023

Abstract
Background
KIR/HLA mismatch in hematopoietic stem cell transplantation (HSCT), particularly in patients with acute myeloid leukemia (AML), was related to decreased recurrence rates, improved engraftment, and a reduction in graft-versus-host disease, according to recent research (GVHD). Uncertainty exists about the impact of KIR/HLA mismatch on haploidentical-HSCTs treated with post-transplant cyclophosphamide (PTCy). We attempted to analyze the effects of KIR/HLA mismatch on clinical outcomes on transplant outcomes using the cohort of 54 AML patients who received a haplo-HSCT with PTCy.

Results
In contrast to KIR/HLA match, our findings showed that donor KIR/HLA mismatch was substantially associated with superior OS (HR, 2.92; (P = 0.04)). Moreover, donor KIR/HLA mismatch (KIR2DS1D/C2+R and KIR2DS2D/C1+R mismatch versus KIR2DL1D/C2−R mm, KIR2DL2/3D/C1−R mm and KIR3DL1D/Bw4− mm) was correlated with the improvements in OS (HR, 0.74; P = 0.085) and activating. KIR/HLA mismatch versus KIR/HLA match was significantly correlated with improvements in OS (HR, .46; P = 0.03) and inhibitory. KIR/HLA mismatch versus KIR/HLA match was enhancement in the OS (HR, .93; P = 0.06). Despite a higher rate of aGvHD (grade I-IV) in the patients with KIR/HLA mismatch compared to KIR/HLA matched (57% vs. 33% (p = 0.04). However, the KIR/HLA mismatch group saw a decreased relapse rate (3.2% vs. 23%, p = 0.04).

Conclusion
This analysis shows the significance of KIR/HLA Incompatibility, other clinical variables like CMV, the relationship between donor/recipient and donor age, and the relationship between donor/recipient and donor age in the haplo-donor selection process. It also suggests that KIR and HLA mismatching between donor and recipient could be routinely performed for haplo-donor selection and may improve clinical outcomes after haplo-HSCTs with PTCy.
Genome-wide identification and expression analysis of VQ gene family under abiotic stress in Coix lacryma-jobi L.
Authors: Wang Yujiao , Lu Xianyong , Fu Yuhua , Wang Hongjuan , Yu Chun , Chu Jiasong , Jiang Benli , Zhu Jiabao 
Published: June 2023

Abstract
Background
Valine-glutamine (VQ) proteins are non-specific plant proteins that have a highly conserved motif: FxxhVQxhTG. These proteins are involved in the development of various plant organs such as seeds, hypocotyls, flowers, leaves and also play a role in response to salt, drought and cold stresses. Despite their importance, there is limited information available on the evolutionary and structural characteristics of VQ family genes in Coix lacryma-jobi.

Results
In this study, a total of 31 VQ genes were identified from the coix genome and classified into seven subgroups (I–VII) based on phylogenetic analysis. These genes were found to be unevenly distributed on 10 chromosomes. Gene structure analysis revealed that these genes had a similar type of structure within each subfamily. Moreover, 27 of ClVQ genes were found to have no introns. Conserved domain and multiple sequence alignment analysis revealed the presence of a highly conserved sequences in the ClVQ protein. This research utilized quantitative real-time PCR (qRT-PCR) and promoter analysis to investigate the expression of ClVQ genes under different stress conditions. Results showed that most ClVQ genes responded to polyethylene glycol, heat treatment, salt, abscisic acid and methyl jasmonate treatment with varying degrees of expression. Furthermore, some ClVQ genes exhibited significant correlation in expression changes under abiotic stress, indicating that these genes may act synergistically in response to adversarial stress. Additionally, yeast dihybrid verification revealed an interaction between ClVQ4, ClVQ12, and ClVQ26.

Conclusions
This study conducted a genome-wide analysis of the VQ gene family in coix, including an examination of phylogenetic relationships, conserved domains, cis-elements and expression patterns. The goal of the study was to identify potential drought resistance candidate genes, providing a theoretical foundation for molecular resistance breeding.
Ecological factors affecting first-time mothers’ satisfaction with Sanhujoriwons (postpartum care centres) from South Korea: a cross-sectional and correlational study
Authors: Song Ju-Eun , Lee Soyeon , Lee Min Kyong , Chae Hyun-Ju 
Published: June 2023

AbstractBackgroundIn South Korea, commercial postpartum care centres, known asSanhujoriwons, have emerged as important institutions aiding mothers’ physical recovery after childbirth. Although previous studies have measured mothers’ satisfaction level withSanhujoriwons, this study applies Bronfenbrenner’s ecological model to identify the factors influencing first-time mothers’ satisfaction withSanhujoriwons.MethodsThis descriptive correlational study involved 212 first-time mothers admitted toSanhujoriwons for two weeks with their new-borns (healthy babies weighing at least 2.5 kg) after giving birth after 37 weeks of pregnancy. Data were collected using a self-report questionnaire at five postpartum care centres in the metropolitan area of South Korea from October to December 2021, on the day of the mothers’ discharge. This study considered ecological factors such as perceived health status, postpartum depression, childcare stress, maternal identity at the individual level; partnership withSanhujoriwonstaff at the microsystem level; and theSanhujoriwons’ education support system at the exo-system level. The data were analysed using descriptive statistics, t-test, one-way ANOVA, correlation analysis, and hierarchical regression analysis using the SPSS 25.0 Win program.ResultsThe mean score of satisfaction withSanhujoriwonswas 59.67 ± 10.14 out of 70, indicating a high level of satisfaction. The hierarchical regression analysis showed that satisfaction withSanhujoriwonswas significantly affected by the perceived health status (β = 0.19,p < 0.001), partnership between mothers and the caregivers (β = 0.26,p < 0.001), and education support system of theSanhujoriwons(β = 0.47,p < 0.001). The explanatory power of the model for these variables was 62.3%.ConclusionsOur results indicate that not only the mother’s health status but also the educational support system of postpartum care centres and partnerships are important for improving first-time mothers’ satisfaction with postpartum care centres. Thus, when developing an intervention program for postpartum care centres, practitioners should focus on developing various kinds of support and strategies to improve the physical health condition of mothers, build partnerships between mothers and care staff, and improve the quality of the educational support offered to mothers. Further studies to develop and test the effectiveness of such intervention programs are strongly suggested.
Contemplating the necessity of surgical treatment for posterior lenticonus: a case report
Authors: Lu Ming-zhi , Cao Wen-li , Xing Yi-qiao 
Published: June 2023

Abstract
Background
Posterior lenticonus is an uncommon congenital abnormality that causes a progressive, localized spherical or conical bulging of the posterior capsular membrane, resulting in an abnormal shape of the lens.

Case presentation
A 13-year-old girl presented with ametropia in both eyes. After mydriasis, examination revealed an oval bubble-shaped alteration with a distinct boundary above the temporal region on the center of the posterior capsule of her left lens. The subcortical region surrounding the alteration appeared feathery and turbid. The patient had no history of trauma or family history of visual impairment. Systemic investigations were normal. A thorough eye examination was performed, which included optometry, ultrasound biomicroscopy, ocular B-Scan, and anterior segment optical coherence, to assess the disease. The patient was diagnosed with posterior lenticonus in the left eye, as well as ametropia and anisometropia in both eyes. Conservative treatment was initiated since the patient’s current best corrected visual acuity was good, and regular monitoring of the condition’s progression was scheduled.

Conclusions
This case report presents a rare instance of posterior lenticonus. The findings of this report raise new considerations regarding the necessity of surgical intervention for this condition.