bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sex‐specific differences in myocardial injury incidence after COVID‐19 mRNA‐1273 booster vaccination
Authors: Buergin Natacha , Lopez‐Ayala Pedro , Hirsiger Julia R. , Mueller Philip , Median Daniela , Glarner Noemi , Rumora Klara , Herrmann Timon , Koechlin Luca , Haaf Philip , Rentsch Katharina , Battegay Manuel , Banderet Florian , Berger Christoph T. , Mueller Christian 
Published: July 2023

AbstractAimsTo explore the incidence and potential mechanisms of oligosymptomatic myocardial injury following COVID‐19 mRNA booster vaccination.Methods and resultsHospital employees scheduled to undergo mRNA‐1273 booster vaccination were assessed for mRNA‐1273 vaccination‐associated myocardial injury, defined as acute dynamic increase in high‐sensitivity cardiac troponin T (hs‐cTnT) concentration above the sex‐specific upper limit of normal on day 3 (48–96 h) after vaccination without evidence of an alternative cause. To explore possible mechanisms, antibodies against interleukin‐1 receptor antagonist (IL‐1RA), the SARS‐CoV‐2‐nucleoprotein (NP) and ‐spike (S1) proteins and an array of 14 inflammatory cytokines were quantified. Among 777 participants (median age 37 years, 69.5% women), 40 participants (5.1%; 95% confidence interval [CI] 3.7–7.0%) had elevated hs‐cTnT concentration on day 3 and mRNA‐1273 vaccine‐associated myocardial injury was adjudicated in 22 participants (2.8% [95% CI 1.7–4.3%]). Twenty cases occurred in women (3.7% [95% CI 2.3–5.7%]), two in men (0.8% [95% CI 0.1–3.0%]). Hs‐cTnT elevations were mild and only temporary. No patient had electrocardiographic changes, and none developed major adverse cardiac events within 30 days (0% [95% CI 0–0.4%]). In the overall booster cohort, hs‐cTnT concentrations (day 3; median 5, interquartile range [IQR] 4–6 ng/L) were significantly higher compared to matched controls (n = 777, median 3 [IQR 3–5] ng/L, p < 0.001). Cases had comparable systemic reactogenicity, concentrations of anti‐IL‐1RA, anti‐NP, anti‐S1, and markers quantifying systemic inflammation, but lower concentrations of interferon (IFN)‐λ1 (IL‐29) and granulocyte‐macrophage colony‐stimulating factor (GM‐CSF) versus persons without vaccine‐associated myocardial injury.ConclusionmRNA‐1273 vaccine‐associated myocardial injury was more common than previously thought, being mild and transient, and more frequent in women versus men. The possible protective role of IFN‐λ1 (IL‐29) and GM‐CSF warrant further studies.
Progress on Separation and Hydrothermal Carbonization of Rice Husk Toward Environmental Applications
Authors: Abe Hiroya , Nakayasu Yuta , Haga Kazutoshi , Watanabe Masaru 
Published: July 2023

AbstractOwing to the increasing global demand for carbon resources, pressure on finite materials, including petroleum and inorganic resources, is expected to increase in the future. Efficient utilization of waste resources has become crucial for sustainable resource acquisition for creating the next generation of industries. Rice husks, which are abundant worldwide as agricultural waste, are a rich carbon source with a high silica content and have the potential to be an effective raw material for energy‐related and environmental purification materials such as battery, catalyst, and adsorbent. Converting these into valuable resources often requires separation and carbonization; however, these processes incur significant energy losses, which may offset the benefits of using biomass resources in the process steps. This review summarizes and discusses the high value of RHs, which are abundant as agricultural waste. Technologies for separating and converting RHs into valuable resources by hydrothermal carbonization are summarized based on the energy efficiency of the process.
Energized people in prominent places: Political support networks, relational energy, and employee innovation implementation
Authors: Grosser Travis J. , Sterling Christopher M. , Piplani Rohit S. 
Published: July 2023

SummaryAlthough affect is a factor likely to impact the success of innovation, little research has been done on the relationship between affect and innovation implementation performance (i.e., an employee's ability to successfully implement innovative ideas and practices). We address this oversight by adopting a social network approach to examine relational energy (i.e., how energized one person is when interacting with another) as a form of high‐activation positive affect likely to influence innovation implementation. We test our hypotheses using a sample of employees in a pharmaceutical research firm (Study 1). Our results indicate that the number of people an employee goes to for political support who report being energized by that employee is positively related to innovation implementation performance. In contrast, the number of people an employee seeks out for political support who are not energized by that employee has negative implications for innovation implementation performance. The average network centrality of an individual's energized network contacts also relates to implementation performance, with this effect being stronger for employees not in a managerial position. A scenario‐based experiment (Study 2) provides support for the causal linkage between feeling energized by a co‐worker and one's willingness to provide instrumental help to the co‐worker.
Successful treatment with atezolizumab in a haemodialysis patient with large cell neuroendocrine carcinoma
Authors: Imai Ryosuke , Kitamura Atsushi 
Published: July 2023

AbstractIn this report, a modified regimen based on IMpower 133 (carboplatin + etoposide + atezolizumab) was administered to a patient diagnosed with large cell neuroendocrine carcinoma (LCNEC) who was concurrently undergoing haemodialysis. Adverse events led to the discontinuation of carboplatin and etoposide after the first course. Nevertheless, the patient exhibited reduction in pulmonary nodule and adrenal metastasis while receiving atezolizumab, indicating its sustained efficacy for a duration of 7 months. To the best of our knowledge, this is the first documented case demonstrating successful treatment with atezolizumab in LCNEC patients undergoing haemodialysis. Atezolizumab can be administered safely in patients undergoing dialysis and is a promising therapeutic option for dialysis patients with LCNEC.
Internal Electric Field‐Modulated Charge Migration Behavior in MoS2/MIL‐53(Fe) S‐Scheme Heterojunction for Boosting Visible‐Light‐Driven Photocatalytic Chlorinated Antibiotics Degradation
Authors: Liu Meng , Ning Yuting , Ren Meng , Fu Xinping , Cui Xuedan , Hou Daibing , Wang Zihan , Cui Jun , Lin Aijun 
Published: July 2023

AbstractInadequate photo‐generated charge separation, migration, and utilization efficiency limit the photocatalytic efficiency. Herein, a MoS2/MIL‐53(Fe) photocatalyst/activator with the S‐scheme heterojunction structure is designed and the charge migration behavior is modulated by the internal electric field (IEF). The IEF intensity is enhanced to 40 mV by modulating band bending potential and the depletion layer length of MoS2. The photo‐generated electron migration process is boosted by constructing the electron migration bridge (Fe‐O‐S) and modulating the IEF as the driving force, confirmed by the density functional theory calculation. Compared with the pristine materials, the photocurrent density of MoS2/MIL‐53(Fe) is significantly enhanced 27.5 times. Contributed by the visible‐light‐driven cooperative catalytic degradation and the high‐efficiency direct photo‐generated electron reduction dichlorination process, satisfactory chlorinated antibiotics removal and detoxification performances are achieved. This study opens up new insights into the application of heterojunctions in photocatalytic activation of PDS in environmental remediation.
Scrophularia amplexicaulis increases anti‐cancer potential of doxorubicin in gastric cancer cells
Authors: Safavi Reza , Soltanzadeh Hossein , Hojjati Bonab Zahra 
Published: July 2023

AbstractIncreased drug resistance has reduced efficiency of chemotherapic drugs such as Doxorubicin (Dox). Scrophularia amplexicaulis (Scr) is one of the most important medicinal plants in Iran that has anti‐cancer activity. The aim of this study was to investigate a novel approach to enhance therapeutic efficacy of Dox (as a chemotherapeutic agent) by co‐administration of Scr (as a bioactive herbal compound) in gastric cancer treatment. In the present study, effects of Dox, Scr, and their combinations (Scr‐Dox) were evaluated on viability and proliferation of two gastric cancer cell lines (AGS and MKN28). Moreover, morphological changes, invasion, migration, colony formation, and apoptosis rate in the treated cancer cells were evaluated. Expression of BAX, BCL2, SAMC, SURVIVIN, CASP9, P53, MMP9, and MMP2 in the treated cancer cells and untreated controls were evaluated by Real‐Time PCR method. Treatments of cancer cells by Scr, Dox, and Scr‐Dox significantly decreased proliferation, invasion, migration, and colony formation of gastric cancer cells. Treatments of cancer cells by Scr, Dox, and Scr‐Dox significantly increased apoptosis rate as well as decreased cells mobility through modification of apoptosis‐ and metastasis‐related genes expression. However, anti‐cancer activity of Scr‐Dox combination was significantly more than Scr and Dox treatments alone. In general, we demonstrated that Scr‐Dox combination therapy exerts more profound anti‐cancer effects on AGS and MKN28 cell lines than Scr and Dox monotherapy.
The rostromedial tegmental nucleus RMTg is not a critical site for ethanol-induced motor activation in rats
Authors: Esposito-Zapero Claudia , Fernández-Rodríguez Sandra , Sánchez-Catalán María José , Zornoza Teodoro , Cano-Cebrián María José , Granero Luis 
Published: July 2023

Abstract
Rationale
Opioid drugs indirectly activate dopamine (DA) neurons in the ventral tegmental area (VTA) through a disinhibition mechanism mediated by mu opioid receptors (MORs) present both on the GABA projection neurons located in the medial tegmental nucleus/tail of the VTA (RMTg/tVTA) and on the VTA GABA interneurons. It is well demonstrated that ethanol, like opioid drugs, provokes VTA DA neuron disinhibition by interacting (through its secondary metabolite, salsolinol) with MORs present in VTA GABA interneurons, but it is not known whether ethanol could disinhibit VTA DA neurons through the MORs present in the RMTg/tVTA.

Objectives
The objective of the present study was to determine whether ethanol, directly microinjected into the tVTA/RMTg, is also able to induce VTA DA neurons disinhibition.

Methods
Disinhibition of VTA DA neurons was indirectly assessed through the analysis of the motor activity of rats. Cannulae were placed into the tVTA/RMTg to perform microinjections of DAMGO (0.13 nmol), ethanol (150 or 300 nmol) or acetaldehyde (250 nmol) in animals pre-treated with either aCSF or the irreversible antagonist of MORs, beta-funaltrexamine (beta-FNA; 2.5 nmol). After injections, spontaneous activity was monitored for 30 min.

Results
Neither ethanol nor acetaldehyde directly administered into the RMTg/tVTA were able to increase the locomotor activity of rats at doses that, in previous studies performed in the posterior VTA, were effective in increasing motor activities. However, microinjections of 0.13 nmol of DAMGO into the tVTA/RMTg significantly increased the locomotor activity of rats. These activating effects were reduced by local pre-treatment of rats with beta-FNA (2.5 nmol).

Conclusions
The tVTA/RMTg does not appear to be a key brain region for the disinhibiting action of ethanol on VTA DA neurons. The absence of dopamine in the tVTA/RMTg extracellular medium, the lack of local ethanol metabolism or both could explain the present results.
Introducing Metaethics
Authors: Johnson King Zoë 
Published: July 2023

AbstractWe often describe actions as good, bad, right, wrong, fair, unkind, deserved, disrespectful, a bit much, and so on. This article asks: Do these terms describe facts about our actions? And do those facts tell us to perform certain actions and refrain from performing others? If so, what exactly does that mean? And, if not, what are we doing when we describe actions in these various ways?
In Defence of Obfuscation
Authors: Høeg Mette Leonard 
Published: July 2023

AbstractIn this article I challenge the standard view that clarity and coherence in moral philosophy and ethics are always good and obscurity necessarily bad. The appraisal of clarity, I argue, entails a risk of reducing and misrepresenting the complex and multifaceted nature of good, productive and true thinking and communication. Uncertainty and obscurity do not necessarily lead to vagueness, imprecision or meaning-obstruction. There are productive forms of uncertainty and there are unproductive forms. Indeed, to be precise, lucid and truthful sometimes requires respecting and linguistically and conceptually reproducing the incoherence, obscurity and uncertainty of reality.
Ablation‐Limited Erosion Rates of Permafrost Riverbanks
Authors: Douglas Madison M. , Miller Kimberly Litwin , Schmeer Maria N. , Lamb Michael P. 
Published: July 2023

AbstractPermafrost thaw is hypothesized to increase riverbank erosion rates, which threatens Arctic communities and infrastructure. However, existing erosion models have not been tested against controlled flume experiments with open‐channel flow past an erodible, hydraulically rough permafrost bank. We conducted temperature‐controlled flume experiments where turbulent water eroded laterally into riverbanks consisting of sand and pore ice. The experiments were designed to produce ablation‐limited erosion such that any thawed sediment was quickly transported away from the bank. Bank erosion rates increased linearly with water temperature, decreased with pore ice content, and were insensitive to changes in bank temperature, consistent with theory. However, erosion rates were approximately a factor of three greater than expected. The heightened erosion rates were due to a greater coefficient of heat transfer from the turbulent water to the permafrost bank caused by bank grain roughness. A revised ablation‐limited bank erosion model with a heat transfer coefficient that includes bank roughness matched our experimental results well. Results indicate that bank erosion along Arctic rivers can accelerate under scenarios of warming river water temperatures for cases where the cadence of bank erosion is set by pore‐ice melting rather than sediment entrainment.
Long-term effect of neoadjuvant radiotherapy in patients with locally advanced rectal mucinous adenocarcinoma: a population-based study of 1514 patients
Authors: Chen Can , Chen Xi , Jiang Jingting 
Published: July 2023

AbstractRectal mucinous adenocarcinoma (RMAC) is a rare and aggressive form of rectal cancer. The effectiveness of neoadjuvant radiotherapy (NRT) for RMAC has not been well studied, and the survival benefit remains controversial. The purpose of this work was to determine the prognostic role of NRT in patients with RMAC by propensity-score matching (PSM). A retrospective cohort study using the Surveillance, Epidemiology, and End Results from 2004 to 2015 was performed. In the multivariate analysis before PSM, NRT provided better OS (HR 0.61, 95% CI 0.52–0.71, p < 0.001) and CSS (HR 0.68, 95% CI 0.56–0.82, p < 0.001). Multivariate analysis after PSM (n = 844) confirmed that patients receiving NRT survived longer than those without NRT (OS: HR 0.60, 95% CI 0.50–0.78, p < 0.001 and CSS: HR 0.68, 95% CI 0.54–0.84, p < 0.001). Subgroup analysis indicated that NRT had significantly improved OS and CSS in stage II RMAC and OS in stage III RMAC after adjusting for various confounding factors.
Mixed-Methods-Ansatz zur Evaluation der Reform der
Psychotherapie-Richtlinie: ein Studienprotokoll
Authors: Diekmann Sandra , Schlierenkamp Sarah , Walendzik Anke , Abels Carina , zur Nieden Pauline , Best Dieter , Schaff Christa , Timmermann Helene , Klipker Kathrin , Marschall Ursula , Wasem Jürgen , Neusser Silke 
Published: July 2023

Zusammenfassung
Hintergrund Die Psychotherapie-Richtlinie (PT-RL) gestaltet die
Rahmenbedingungen der Psychotherapie in der vertragsärztlichen
Versorgung in Deutschland. Aufgrund der Diskussion um Wartezeiten und
inadäquate Versorgung von Betroffenen trat 2017 eine Reform in Kraft, um
den Zugang zur Psychotherapie sowie den gesamten Versorgungs- und
Behandlungsverlauf zu verbessern. Ziel des Projektes ist die Evaluation der neu
eingeführten Versorgungselemente in der PT-RL sowie die Identifikation
möglicher Implementierungsschwierigkeiten.
Methoden Zur Evaluation der Reform der PT-RL finden sowohl quantitative
als auch qualitative Methoden Anwendung. Um einen Vergleich der
Versorgungssituation vor und nach der Reform durchzuführen, wird eine
vergleichende retrospektive, kohortenbasierte Analyse auf Basis anonymisierter
Routinedaten der BARMER und der AOK durchgeführt. Zusätzlich
wird mit Hilfe einer Querschnittsanalyse erfasst, wie die neuen
Versorgungselemente in der Praxis umgesetzt werden. Dazu erfolgt eine Befragung
von Psychotherapeut*innen, Hausärzt*innen und
Patient*innen. Fokusgruppen mit relevanten Interessensgruppen stellen
zusammen mit einer Literaturrecherche die Basis für die Befragung dar.
Zusammen mit den Routinedaten zur Versorgungssituation nach Reform der PT-RL und
aggregierten, anonymisierten Daten der KBV zur vertragsärztlichen
Versorgung sowie zur Inanspruchnahme der Terminservicestellen ergeben die
Befragungsergebnisse die Datenbasis für die Querschnittsanalyse.
Schlussfolgerung Durch die Verbindung von quantitativen und qualitativen
Daten können die Auswirkungen der Strukturreform der PT-RL von 2016 auf
individueller und struktureller Ebene sowie in Bezug auf den gesamten
Versorgungs- und Behandlungsprozess analysiert werden. Darauf aufbauend werden
Vorschläge für eine bedarfsgerechte Weiterentwicklung der PT-RL
unter Berücksichtigung der Perspektiven verschiedener Interessensgruppen
ausgearbeitet.
A socio-psychological analysis of goal-setting when deciding to learn a second language
Authors: D’Orazzi Giuseppe 
Published: July 2023

Abstract
This study bridges a gap in the current research on motivation and demotivation learning a second language (L2). It is meant to provide an overview of students’ goal setting when they start to learn an L2 at university level in Australia. Drawing on goal-setting and learning goal orientation constructs (cf. Miller, 2020), goal formation is deconstructed and analysed to throw new light on students’ psychological processes identified at the micro level and the influences on goal setting stemming from the social context at the macro level in which students operate. The interaction between the two levels is explored in order to understand which dynamics lie behind research participants’ desire of gaining proficiency in French, German, Italian, and Spanish. Qualitative data analysis outcomes are shown in an attempt to provide clear and applicable pedagogical suggestions for L2 practitioners (see, e.g., Al-Hoorie et al., 2021).
Updates to the Diagnosis and Clinical Management of Helicobacter pylori Infections
Authors: Shakir Salika Mehreen , Shakir Faiz Ahmed , Couturier Marc Roger 
Published: July 2023

Abstract

Background
Helicobacter pylori (H. pylori) affects nearly half of the world's populations with high incidence and prevalence rates in developing countries. Infection with H. pylori increases the risk of developing peptic ulcer disease and gastric cancer. This review provides a summary of the prevalence and microbiology of H. pylori with emphasis on the current diagnostic methods and clinical management strategies.

Content
This review discusses current options and developments in H. pylori diagnosis with the challenges and advantages associated with both noninvasive and invasive methods. The advantages of molecular methods for the diagnosis of H. pylori infection and prediction of clarithromycin resistance directly from stool or tissue biopsies are discussed. In addition, we provide a brief review on the treatment for H. pylori indicated in patients with evidence of active infection with the organism's antimicrobial resistance patterns taken into consideration.

Summary
Testing for H. pylori has largely centered around fecal antigen testing, urea breath testing, and immunohistochemical staining from tissue biopsies. Culture-based diagnostics followed by phenotypic antimicrobial susceptibility testing is the gold standard for detection of resistance patterns. Due to the fastidious nature of the organism, culture methods are time consuming and labor intensive. Rapid nucleic acid amplification tests for H. pylori identification from direct specimens and molecular determination of drug resistance markers are accurate alternatives for H. pylori diagnosis but are not widely adopted. H. pylori antimicrobial resistance rates are on the rise due to the widespread use of antibiotics. Antibiotic regimens including the quadruple therapy and non-clarithromycin triple therapies have a higher success rate, with newer vonoprazon-based regimens showing promising eradication rates.
Filming the Photographic Object
Authors: Hallas Roger 
Published: July 2023

Abstract
Chapter 2 examines how photographic materiality impacts the representability of violence in documentaries about war, conflict, and atrocity. The material objecthood of vernacular photographs plays as significant a role as the indexical quality of the images. These documentary films engage with three facets of photographic materiality. The first section examines films about rediscovered photo albums made by German war perpetrators in which their emphatic foundness promises rare photographic evidence of atrocity, but simultaneously engenders opacity from the album’s missing oral narration. The second section turns to the physical handling of photographs in documentary films, in which bodily gestures toward photographic objects facilitate several political meanings, from destabilizing the public/private division to bearing witness to the disappeared by an embodied performance of habeas corpus. The final section addresses metadata as part of digital photography’s materiality in documentaries that pursue the forensic investigation of human-rights violations through digitally rendered mise-en-scène.
The Covenant with Death
Authors: Landy Francis 
Published: July 2023

Abstract
This chapter juxtaposes two chapters concerned with death: chs 5 and 28. In ch. 5 there is a series of woe-oracles condemning the false values, exploitation, and injustice of the Judean elite. At their centre, the drunkards descend into the underworld and continue feasting there. Drunkenness becomes a symbol for all human defences against the imminence of death. The chapter relates this passage to the misogynistic stripping of the daughters of Zion in 3.16–24, since Sheol, the underworld, is a female subject. In ch. 28, the sceptical rulers/aphorists of Jerusalem make a covenant with death, which they think will protect them from annihilation. In contrast, there will be a new Temple, founded with justice and righteousness, and a new era, in which YHWH will replace the glory of Samaria.