bluuebunny/crossref_metadata_2025_split huggingface dataset:
Real options analysis for valuation of climate adaptation pathways with application to transit infrastructure
Authors: Martello Michael V. , Whittle Andrew J. , Oddo Perry C. , de Neufville Richard 
Published: September 2023

AbstractClimate change and sea‐level rise (SLR) are expected to increase the frequency and intensity of coastal flood events, posing risks to coastal communities and infrastructure. While regional climate adaptation investments can provide substantive flood protection, existing plans often neglect uncertainty in future climate conditions and adaptation performance, consequently neglecting the option value of flexibly implementing proposed projects. Addressing this gap, we develop and employ a generalizable real options analysis (ROA) valuation framework that considers how uncertainty in adaptation project costs, SLR, flood severity, and flood losses inform the full range of adaptation performance outcomes. We further propose and apply a novel, computationally efficient flood loss sampling algorithm to estimate the consequences of randomly arriving coastal flood events. We apply this ROA framework to assess the option value of flexibly timing adaptation investments over time, investigating an adaptation pathway proposed by the City of Boston from the perspective of the regional transit system manager. Our results suggest that flexible implementation can provide significant option value in the near‐ to mid‐term (>30 years), with the highest option values under low‐probability, high‐consequence scenarios. Our results also suggest adaptation pathway performance in the latter half of the 21st century is most sensitive to uncertainty in SLR, flood loss estimates, and flood frequency, underscoring the importance of uncertainty quantification in the long‐term valuation of adaptation investments.
Exchange rate shocks, multinational firms and access to finance
Authors: Sharma Anisha 
Published: September 2023

AbstractI estimate the effect of financial constraints on the response of firms that import inputs to a large exchange rate depreciation. Using data from a census on Indonesian firms, I find that while domestic importers face lower value added due to a rise in their costs of production, foreign‐owned importers fare better: they are more likely to sustain higher value added, hire more labor and use more materials than domestic owned firms. These effects are driven by firms in industries with high demand for external finance, emphasizing the importance of access to finance in mitigating the impact of trade and credit shocks. This suggests another channel through which FDI can add value to a firm in a developing country, particularly with the increasing importance of trade in intermediate goods.
The politics of energy privatization in Latin America: Contours and directions
Authors: Venegas Mario 
Published: September 2023

AbstractPrescribed as a measure from international organizations such as the International Monetary Fund and networks of creditors to manage debt, privatization of energy in Latin America has been a key policy from the Washington Consensus since the 1980s into the current period. The waves of privatization and neoliberal reforms that have swept Latin America during the 1980s and through the 1990s and 2000s have also brought with them massive resistance from constituencies such as labor unions, indigenous communities, students, and workers in the region. This review essay explores key debates on the politics of energy privatization in Latin America, with attention to three central questions: (1) How do foreign (exogenous) and national (endogenous) factors interact in the diffusion and implementation of energy privatization? (2) Under what conditions are protests against energy privatization effective in reversing these policies? And (3) What are the broader effects of energy privatization in the 21st century? I end this review essay with new directions for research that can help sociologists synthesize insights across political science and economics, and shed light to approaches that can be beneficial to sociologists conducting research on privatization and neoliberal reforms in Latin America in the 21st century.
Towards a spatio‐temporal multicriteria evaluation method: A suitability analysis of residential units in a 3D urban environment
Authors: Munn Kendra , Dragićević Suzana 
Published: September 2023

AbstractSpatial multi‐criteria evaluation (MCE) techniques aid urban planning management by analyzing decision problem alternatives for solutions to help inform decision‐making. However, there is a lack of such methods that incorporate the temporal dimension, an important factor when analyzing the dynamic urban landscape and decisions surrounding its changes. A novel spatio‐temporal MCE approach is proposed that operates in three‐dimensional (3D) space and time to identify changing suitability values of decision alternatives. This space–time method is implemented to evaluate the suitability of residential units over a 15‐year period in part of downtown City of Vancouver, Canada. The results indicate that the majority of units exhibit a decrease in suitability with time due to depreciation and reduction of assets like view and privacy from the construction of new buildings. The proposed method can be used by urban planners and developers to assist in long‐term assessments of proposed development scenarios and their impact on existing urban infrastructure.
Effect of Layer Addition on Residual Stresses of Wire Arc Additive Manufactured Stainless Steel Specimens
Authors: Rouquette Sébastien , Cambon Camille , Bendaoud Issam , Cabeza Sandra , Soulié Fabien 
Published: September 2023

Abstract
Residual stresses have been characterized in four Wire Arc Additive Manufacturing specimens with neutron diffraction technique. First, two methods are investigated for obtaining the reference diffracted angle θ0 that is required for the computation of microstrains and, thus, the stresses; θ0 was obtained with two approaches. The first one required a strain-free specimen in order to get directly the reference diffracted angles θ0 in the three principal directions. The second one is based on the plane stress assumption to get θ0 indirectly by imposing that the normal stress was equal to zero. Both methods led to similar residual stress profiles for the one-layer specimen which validated this approach for all specimens without a strain-free specimen available. The second part of this work focused on the modification of the residual stresses in the specimen following the addition of a new deposit. The neutron diffraction measurements showed that the longitudinal stress was tensile in the heat-affected and fusion zones with a maximum value located at the parent material–layers interface where the thermal loadings were applied. A decrease of this maximum value from 257 MPa to 199 MPa appeared after deposition of a new layer which is due to some stress relaxation effect. Inside the parent material, a large zone presents compressive longitudinal stress up to −170 MPa. The bottom part of the parent material is under tensile stress likely due to its upward bending following the thermal contraction of the deposited layers during cooling to ambient temperature.
Isolation of novel simian adenoviruses from macaques for development of a vector for human gene therapy and vaccines
Authors: Lan Wendong , Quan Lulu , Li Yiqiang , Ou Junxian , Duan Biyan , Mei Ting , Tan Xiao , Chen Weiwei , Feng Liqiang , Wan Chengsong , Zhao Wei , Chodosh James , Seto Donald , Zhang Qiwei 
Published: September 2023

ABSTRACT
Both human and non-human simian adenoviruses (HAdVs and SAdVs, respectively) have been used as gene therapy and vaccine vectors. The high prevalence of HAdVs and the neutralizing antibodies associated with prior infection, may limit HAdV-based vector use in human subjects. To overcome this drawback, a vector derived from a newly isolated and characterized macaque adenovirus was constructed. SAdVs (33.9%) were screened from 115 SAdV fecal samples collected at a zoological park. One novel SAdV was isolated and the whole genome was sequenced and analyzed. The pre-existing neutralizing antibody levels were very low against this isolate (10%). Interestingly, SAdV vector constructs that lack E3 region could not produce infectious progeny in HEK293 cells, suggesting that the E3 region is necessary for SAdV replication. The absence of E3 region could be compensated for by replacement with HAdV-5 E4orf6; the resultant construct could replicate well in HEK293 cells. The enhanced Green Fluorescent Protein (eGFP) was inserted into SAdV E3 region and expressed at high level. One-step growth curve showed that the replication of the SAdVs with HAdV-5 E4orf6 substitution and E1/E3 deletion was similar to that of wild-type SAdVs in HEK293 cells, but the modified SAdVs were replication-deficient in A549 cells which lack HAdV-5 E1A and E1B. Finally, we demonstrated that GZ3-12 could infect cells expressing hCAR or hDSG2 receptors. The successful isolation, characterization, and modification of novel SAdVs provide a potentially important vaccine and gene therapy candidate and a new strategy for the rapid acquisition and development of non-HAdV-based alternative vectors for human health applications.

IMPORTANCE
Adenoviruses are widely used in gene therapy and vaccine delivery. Due to the high prevalence of human adenoviruses (HAdVs), the pre-existing immunity against HAdVs in humans is common, which limits the wide and repetitive use of HAdV vectors. In contrast, the pre-existing immunity against simian adenoviruses (SAdVs) is low in humans. Therefore, we performed epidemiological investigations of SAdVs in simians and found that the SAdV prevalence was as high as 33.9%. The whole-genome sequencing and sequence analysis showed SAdV diversity and possible cross species transmission. One isolate with low level of pre-existing neutralizing antibodies in humans was used to construct replication-deficient SAdV vectors with E4orf6 substitution and E1/E3 deletion. Interestingly, we found that the E3 region plays a critical role in its replication in human cells, but the absence of this region could be compensated for by the E4orf6 from HAdV-5 and the E1 expression intrinsic to HEK293 cells.
Retrospective identification of pathogenic mycobacterial species in fish:
Mycobacterium pseudoshottsii
YM-3, isolated from a yellowtail fish in 1986 in Kochi, Japan
Authors: Imajoh Masayuki , Yoshida Shiomi , Nonaka Lisa , Fukushima Yukari , Nakajima Chie , Suzuki Yasuhiko , Wada Takayuki 
Published: September 2023

ABSTRACT

The complete genome sequence of mycobacterial strain YM-3, isolated from cultured yellowtail in 1986, was determined. The strain was
Mycobacterium pseudoshottsii
, a closely related subspecies of
Mycobacterium marinum
, so the strain was isolated earlier than the first report of the subspecies in 2005.
Genome sequences of key bacterial symbionts of entomopathogenic nematodes:
Xenorhabdus cabanillasii
DSM17905,
Xenorhabdus ehlersii
DSM16337,
Xenorhabdus japonica
DSM16522,
Xenorhabdus koppenhoeferii
DSM18168, and
Xenorhabdus mauleonii
DSM17908
Authors: Robertson Raegan , Conrad Katie , Ahuja Baarik , Göker Markus , Hahnke Richard L. , Spunde Alex , Ivanova Natalia N. , Seshadri Rekha , Stephens Craig 
Published: September 2023

ABSTRACT

Xenorhabdus
species are bacterial symbionts of entomopathogenic
Steinernema
nematodes, in which they produce diverse secondary metabolites implicated in pathogenesis. To expand resources for natural product prospecting and exploration of host-symbiont-pathogen relationships, the genomes of
Xenorhabdus cabanillasi, Xenorhabdus ehlersii
,
Xenorhabdus japonica
,
Xenorhabdus koppenhoeferii
, and
Xenorhabdus mauleonii
were analyzed.
Draft genome sequence of biofilm-forming methicillin-resistant
Staphylococcus aureus
MTR_V1 strain isolated from a ready-to-eat food in Bangladesh
Authors: Ballah Fatimah Muhammad , Islam Md. Saiful , Ievy Samina , Ferdous Farhana Binte , Sobur Md. Abdus , Rahman AMM Taufiquer , Rahman Marzia , Hoque M. Nazmul , Hassan Jayedul , Rahman Md. Tanvir 
Published: September 2023

ABSTRACT

This announcement provides the genome sequence of the biofilm-forming methicillin-resistant
Staphylococcus aureus
MTR_V1 strain isolated from a ready-to-eat food sample in Bangladesh. Our assembled genome had a length of 2.8 Mb, 27 contigs, two CRISPR arrays, 38 predicted antibiotic resistance genes, and 66 predicted virulence factor genes.
Incidence of infections in patients with psoriatic arthritis and axial spondyloarthritis treated with biological or targeted disease-modifying agents: a systematic review and meta-analysis of randomised controlled trials, open-label studies and observational studies
Authors: Aureal Melanie , Seauve Milene , Laplane Soline , Lega Jean-Christophe , Cabrera Natalia , Coury Fabienne 
Published: September 2023

ObjectiveTo estimate the incidence of infections among patients with psoriatic arthritis (PsA) or axial spondyloarthritis (axSpA), two distinct phenotypes included in the large group of spondyloarthritis (SpA), treated with tumour necrosis-factor-inhibitors, interleukin-17-inhibitors, Janus kinase-inhibitors, IL-23 or IL-12/23-inhibitors (IL-12/23i), phosphodiesterase 4-inhibitors or cytotoxic T-lymphocyte associated protein 4-Ig.MethodsA meta-analysis of randomised controlled trials (RCTs), open-label extension and observational studies was conducted. Serious infections were defined as infections that were life-threatening, required intravenous antibiotics and/or hospitalisation. Non-serious infections did not meet these severity criteria. The incidence rates (IR) were reported for each diagnosis by treatment class and study type using random-effect model to create a 95% CI.ResultsAmong 23 333 PsA patients and 11 457 axSpA patients, there were 1.09 serious infections per 100 patient-years (PY) (95% CI 0.85 to 1.35) with similar IR in PsA (0.96 per 100 PY 95% CI 0.69 to 1.28) and axSpA (1.09 per 100 PY 95% CI 0.76 to 1.46). The IR was lower in RCTs (0.77 per 100 PY 95% CI 0.41 to 1.20) compared with observational studies (1.68 per 100 PY 95% CI 1.03 to 2.47). In PsA patients, the lowest IR value was observed with IL-12/23i (0.29 per 100 PY 95% CI 0.00 to 1.03). There were 53.0 non-serious infections per 100 PY (95% CI 43.47 to 63.55) in 7257 PsA patients and 5638 axSpA patients. The IR was higher in RCTs (69.95 per 100 PY 95% CI 61.59 to 78.84) compared with observational studies (15.37 per 100 PY 95% CI 5.11 to 30.97).ConclusionSerious infections were rare events in RCTs and real-life studies. Non-serious infections were common adverse events, mainly in RCTs.PROSPERO registration numberCRD42020196711
Evaluation of Vicia faba plant genotypes using non-destructive vibrational molecular spectroscopic technique (ATR-FT/IR): molecular structure profiles of protein in relation to nutritional characteristics
Authors: Espinosa Maria E. Rodríguez , Yu Peiqiang 
Published: September 2023

This study aimed to evaluate the impact of genotypes and tannin levels on the nutritional characteristics of faba bean seeds and their relation to protein molecular structure profiles using Fourier transform infrared spectroscopy (FTIR). Eight genotypes with low tannin (LT, n = 3) and normal tannin (NT, n = 5) levels were studied. Standard methods of analysis and NRC 2001 were used to obtain chemical and energy parameters. The protein molecular spectral study was performed using a spectrometer JASCO FT/IR–4200. Molecular features were analyzed in the mid-infrared region at ~4000–800 cm−1 and protein-related functional groups were obtained using OMNIC software. Results showed higher ( P < 0.01) soluble crude protein (SCP), rapidly degradable protein fraction (PA2), and intestinal digestibility of bypass protein (dIDP) in LT than NT. The slowly degradable protein fraction (PB2) was higher in NT ( P < 0.01) compared to LT. Higher absorbance was observed in spectral peaks related to amide I, amide II, and β-sheet in NT ( P < 0.05) compared to LT. The area ratio of amide I to amide II and the height ratio of α-helix to β-sheet were higher in LT compared to NT ( P < 0.01). This study provides a better understanding of associations between structure and nutritional characteristics in faba bean genotypes with different tannin levels.
Minor minerals, major implications: using key mineral phases to unravel the formation and evolution of Earth's crust
Authors: van Schijndel Valby , Cutts Kathryn A. , Pereira Inês , Guitreau Martin , Volante Silvia , Tedeschi Mahyra 
Published: September 2023

Abstract

The investigation of key minerals including zircon, apatite, titanite, rutile, monazite, xenotime, allanite, baddeleyite and garnet can retain critical information about petrogenetic and geodynamic processes and may be utilized to understand complex geological histories and the dynamic evolution of the continental crust. They act as small but often robust petrochronological capsules and provide information about crustal evolution, from local processes to plate tectonics and supercontinent cycles. They offer us insights into processes of magmatism, sedimentation, metamorphism and alteration, even when the original protolith is not preserved.
In situ
techniques have enabled a more in-depth understanding of trace element behaviour in these minerals within their textural context. This has led to more meaningful ages for many stages of geological events. New developments of analytical procedures have further allowed us to expand our petrochronological toolbox while improving precision and accuracy. Combining multiple proxies with multiple minerals has contributed to new interpretations of the crustal history of our planet.
Influence of Deposition Parameters of ITO Films on the Performance of HJT Solar Cells
Authors: Huang Guoping , Zhao Guixiang , Huang Xixi , Zhuang Hao , Zhang Zhongjian , Gao Ronggang , Xie Fengxian 
Published: September 2023

TCO (transparent conductive oxide) films are widely used in solar cells due to the characteristics of transparency and conductivity. In this paper, ITO (indium tin oxide) transparent conductive films are prepared on common slides by DC magnetron sputtering, and the preparation process and characteristics of ITO films are studied. The target for sputtering is ITO, with the mass ratio of In203 and Sn02 was 90% : 10%. The sheet resistance, carrier concentration, and carrier mobility of ITO films are measured and analyzed by a UV-Vis spectrophotometer, four-point probe, and Hall effect measurement system. By changing the oxygen content, deposition temperature, and sputtering power to studied the effects on the light transmittance and electrical conductivity of the ITO films, further studied the effects on the HJT (heterojunction with intrinsic thin film) solar cells, and finally determined the appropriate preparation parameters. Results show that the resistance is

6
.

4

∗

10

−
4

Ω
•
cm

, the light transmittance is beyond 90.6%, efficiency is 23.78%, and bifacial ratio is 84% when oxygen content is 2.2%, sputtering power is 3 kw, and deposition temperature is 190°C.
Precision Oncology Comes of Age: Designing Best-in-Class Small Molecules by Integrating Two Decades of Advances in Chemistry, Target Biology, and Data Science
Authors: Stuart Darrin D. , Guzman-Perez Angel , Brooijmans Natasja , Jackson Erica L. , Kryukov Gregory V. , Friedman Adam A. , Hoos Axel 
Published: September 2023

Abstract

Small-molecule drugs have enabled the practice of precision oncology for genetically defined patient populations since the first approval of imatinib in 2001. Scientific and technology advances over this 20-year period have driven the evolution of cancer biology, medicinal chemistry, and data science. Collectively, these advances provide tools to more consistently design best-in-class small-molecule drugs against known, previously undruggable, and novel cancer targets. The integration of these tools and their customization in the hands of skilled drug hunters will be necessary to enable the discovery of transformational therapies for patients across a wider spectrum of cancers.

Significance:
Target-centric small-molecule drug discovery necessitates the consideration of multiple approaches to identify chemical matter that can be optimized into drug candidates. To do this successfully and consistently, drug hunters require a comprehensive toolbox to avoid following the “law of instrument” or Maslow's hammer concept where only one tool is applied regardless of the requirements of the task. Combining our ever-increasing understanding of cancer and cancer targets with the technological advances in drug discovery described below will accelerate the next generation of small-molecule drugs in oncology.
Integrated Assessment of Computational Coronary Physiology From a Single Angiographic View in Patients Undergoing TAVI
Authors: Fezzi Simone , Ding Daixin , Scarsini Roberto , Huang Jiayue , Del Sole Paolo Alberto , Zhao Qiang , Pesarini Gabriele , Simpkin Andrew , Wijns William , Ribichini Flavio , Tu Shengxian 
Published: September 2023

BACKGROUND:
Angiography-derived computational physiology is an appealing alternative to pressure-wire coronary physiology assessment. However, little is known about its reliability in the setting of severe aortic stenosis. This study sought to provide an integrated assessment of epicardial and microvascular coronary circulation by means of single-view angiography-derived physiology in patients with severe aortic stenosis undergoing transcatheter aortic valve implantation (TAVI).

METHODS:
Pre-TAVI angiographic projections of 198 stenotic coronary arteries (123 patients) were analyzed by means of Murray’s law-based quantitative flow ratio and angiography microvascular resistance. Wire-based reference measurements were available for comparison: fractional flow reserve (FFR) in all cases, instantaneous wave-free ratio in 148, and index of microvascular resistance in 42 arteries.

RESULTS:

No difference in terms of the number of ischemia-causing stenoses was detected between FFR ≤0.80 and Murray’s law-based quantitative flow ratio ≤0.80 (19.7% versus 19.2%;
P
=0.899), while this was significantly higher when instantaneous wave-free ratio ≤0.89 (44.6%;
P
=0.001) was used. The accuracy of Murray’s law-based quantitative flow ratio ≤0.80 in predicting pre-TAVI FFR ≤0.80 was significantly higher than the accuracy of instantaneous wave-free ratio ≤0.89 (93.4% versus 77.0%;
P
=0.001), driven by a higher positive predictive value (86.9% versus 50%). Similar findings were observed when considering post-TAVI FFR ≤0.80 as reference. In 82 cases with post-TAVI angiographic projections, Murray’s law-based quantitative flow ratio values remained stable, with a low rate of reclassification of stenosis significance (9.9%), similar to FFR and instantaneous wave-free ratio. Angiography microvascular resistance demonstrated a significant correlation (Rho=0.458;
P
=0.002) with index of microvascular resistance, showing an area under the curve of 0.887 (95% CI, 0.752–0.964) in predicting index of microvascular resistance ≥25.

CONCLUSIONS:
Angiography-derived physiology provides a valid, reliable, and systematic assessment of the coronary circulation in a complex scenario, such as severe aortic stenosis.