bluuebunny/crossref_metadata_2025_split huggingface dataset:
Research trends and hotspots of neuropathic pain in neurodegenerative diseases: a bibliometric analysis
Authors: Fu Yujie , Gong Chan , Zhu Chenchen , Zhong Weiquan , Guo Jiabao , Chen Binglin 
Published: July 2023

BackgroundNeuropathic pain is caused by a neurological injury or disease and can have a significant impact on people’s daily lives. Studies have shown that neuropathic pain is commonly associated with neurodegenerative diseases. In recent years, there has been a lot of literature on the relationship between neuropathic pain and neurodegenerative diseases. However, bibliometrics is rarely used in analyzing the general aspects of studies on neuropathic pain in neurodegenerative diseases.MethodsThe bibliometric analysis software CiteSpace and VOSviewer were used to analyze the knowledge graph of 387 studies in the Science Citation Index Expanded of the Web of Science Core Collection Database.ResultsWe obtained 2,036 documents through the search, leaving 387 documents after culling. 387 documents were used for the data analysis. The data analysis showed that 330 papers related to neuropathic pain in neurodegenerative diseases were published from 2007–2022, accounting for 85.27% of all published literature. In terms of contributions to the scientific study of neuropathic pain, the United States is in the top tier, with the highest number of publications, citations, and H-indexes.ConclusionThe findings in our study may provide researchers with useful information about research trends, frontiers, and cooperative institutions. Multiple sclerosis, Parkinson’s disease, and Alzheimer’s disease are the three most studied neurodegenerative diseases. Among the pathological basis of neurodegenerative diseases, microglia-regulated neuroinflammation is a hot research topic. Deep brain stimulation and gamma knife radiosurgery are two popular treatments.
The prognostic value of 19S ATPase proteasome subunits in acute myeloid leukemia and other forms of cancer
Authors: Tychhon Boranai , Allen Jesse C. , Gonzalez Mayra A. , Olivas Idaly M. , Solecki Jonathan P. , Keivan Mehrshad , Velazquez Vanessa V. , McCall Emily B. , Tapia Desiree N. , Rubio Andres J. , Jordan Connor , Elliott David , Eiring Anna M. 
Published: July 2023

IntroductionThe ubiquitin-proteasome system (UPS) is an intracellular organelle responsible for targeted protein degradation, which represents a standard therapeutic target for many different human malignancies. Bortezomib, a reversible inhibitor of chymotrypsin-like proteasome activity, was first approved by the FDA in 2003 to treat multiple myeloma and is now used to treat a number of different cancers, including relapsed mantle cell lymphoma, diffuse large B-cell lymphoma, colorectal cancer, and thyroid carcinoma. Despite the success, bortezomib and other proteasome inhibitors are subject to severe side effects, and ultimately, drug resistance. We recently reported an oncogenic role for non-ATPase members of the 19S proteasome in chronic myeloid leukemia (CML), acute myeloid leukemia (AML), and several different solid tumors. In the present study, we hypothesized that ATPase members of the 19S proteasome would also serve as biomarkers and putative therapeutic targets in AML and multiple other cancers.MethodsWe used data from The Cancer Genome Atlas (TCGA) and the Clinical Proteomic Tumor Analysis Consortium (CPTAC) available at UALCAN and/or GEPIA2 to assess the expression and prognostic value of proteasome 26S subunit, ATPases 1-6 (PSMC1-6) of the 19S proteasome in cancer. UALCAN was also used to associate PSMC1-6 mRNA expression with distinct clinicopathological features. Finally, cBioPortal was employed to assess genomic alterations of PSMC genes across different cancer types.ResultsThe mRNA and protein expression of PSMC1-6 of the 19S proteasome were elevated in several cancers compared with normal controls, which often correlated with worse overall survival. In contrast, AML patients demonstrated reduced expression of these proteasome subunits compared with normal mononuclear cells. However, AML patients with high expression of PSMC2-5 had worse outcomes.DiscussionAltogether, our data suggest that components of the 19S proteasome could serve as prognostic biomarkers and novel therapeutic targets in AML and several other human malignancies.
Exploring the alteration of gut microbiota and brain function in gender-specific Parkinson’s disease based on metagenomic sequencing
Authors: Zhang Minna , Zhai Zhiyuan , Yang Bo , He Le , Wang Jingyi , Dai Weijie , Xue Liujun , Yang Xiaozhong , Feng Yun , Wang Honggang 
Published: July 2023

BackgroundThe role of the microbiota-gut-brain axis in Parkinson’s disease (PD) has received increasing attention. Although gender differences are known to an essential role in the epidemiology and clinical course of PD, there are no studies on the sex specificity of the microbiota-gut-brain axis in the development and progression of PD.MethodsFresh fecal samples from 24 PD patients (13 males, 11 females) were collected for metagenomic sequencing. The composition and function of the gut microbiota were analyzed by resting-state functional magnetic resonance imaging (fMRI). Gender-dependent differences in brain ALFF values and their correlation with microbiota were further analyzed.ResultsThe relative abundance of Propionivibrio, Thermosediminibacter, and Flavobacteriaceae_noname was increased in male PD patients. LEfse analysis showed that Verrucomicrobial, Akkermansiaceae, and Akkermansia were dominant in the males. In female patients, the relative abundance of Propionicicella was decreased and Escherichia, Escherichia_coli, and Lachnospiraceae were predominant. The expression of the sesquiterpenoid and triterpenoid biosynthesis pathways was increased in male PD patients and was statistically different from females. Compared to the Male PD patients, female patients showed decreased ALFF values in the left inferior parietal regions, and the relative abundance of Propionivibrio was positively correlated with the regional ALFF values.ConclusionOur study provides novel clinical evidence of the gender-specific relationship between gut microbiota alterations and brain function in PD patients, highlighting the critical role of the microbiota-gut-brain axis in gender differences in PD.
Production, identification, in silico analysis, and cytoprotection on H2O2-induced HUVECs of novel angiotensin-I-converting enzyme inhibitory peptides from Skipjack tuna roes
Authors: Zhu Wang-Yu , Wang Yu-Mei , Ge Ming-Xue , Wu Hua-Wei , Zheng Shuo-Lei , Zheng Huai-Yu , Wang Bin 
Published: July 2023

BackgroundExceeding 50% tuna catches are regarded as byproducts in the production of cans. Given the high amount of tuna byproducts and their environmental effects induced by disposal and elimination, the valorization of nutritional ingredients from these by-products receives increasing attention.ObjectiveThis study was to identify the angiotensin-I-converting enzyme (ACE) inhibitory (ACEi) peptides from roe hydrolysate of Skipjack tuna (Katsuwonus pelamis) and evaluate their protection functions on H2O2-induced human umbilical vein endothelial cells (HUVECs).MethodsProtein hydrolysate of tuna roes with high ACEi activity was prepared using flavourzyme, and ACEi peptides were isolated from the roe hydrolysate using ultrafiltration and chromatography methods and identified by ESI/MS and Procise Protein/Peptide Sequencer for the N-terminal amino acid sequence. The activity and mechanism of action of isolated ACEi peptides were investigated through molecular docking and cellular experiments.ResultsFour ACEi peptides were identified as WGESF (TRP3), IKSW (TRP6), YSHM (TRP9), and WSPGF (TRP12), respectively. The affinity of WGESF (TRP3), IKSW (TRP6), YSHM (TRP9), and WSPGF (TRP12) with ACE was −8.590, −9.703, −9.325, and −8.036 kcal/mol, respectively. The molecular docking experiment elucidated that the significant ACEi ability of WGESF (TRP3), IKSW (TRP6), YSHM (TRP9), and WSPGF (TRP12) was mostly owed to their tight bond with ACE’s active sites/pockets via hydrophobic interaction, electrostatic force and hydrogen bonding. Additionally, WGESF (TRP3), IKSW (TRP6), YSHM (TRP9), and WSPGF (TRP12) could dramatically elevate the Nitric Oxide (NO) production and bring down endothelin-1 (ET-1) secretion in HUVECs, but also abolish the opposite impact of norepinephrine (0.5 μM) on the production of NO and ET-1. Moreover, WGESF (TRP3), IKSW (TRP6), YSHM (TRP9), and WSPGF (TRP12) could lower the oxidative damage and apoptosis rate of H2O2-induced HUVECs, and the mechanism indicated that they could increase the content of NO and activity of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) to decrease the generation of reactive oxygen species (ROS) and malondialdehyde (MDA).ConclusionWGESF (TRP3), IKSW (TRP6), YSHM (TRP9), and WSPGF (TRP12) are beneficial ingredients for healthy products ameliorating hypertension and cardiovascular diseases.
Comparing the cognitive functioning of middle-aged and older foreign-origin population in Estonia to host and origin populations
Authors: Abuladze Liili , Sakkeus Luule , Selezneva Elena , Sinyavskaya Oksana 
Published: July 2023

BackgroundIn migration and health research, the healthy migrant effect has been a common finding, but it usually pertains to specific contexts only. Existing findings are inconsistent and inconclusive regarding the cognitive functioning of the (aging) foreign-origin population relative to the populations of their host and sending countries. Moreover, this comparison is an understudied design setting.ObjectiveWe analyze the outcomes and associations of cognitive functioning outcomes of the non-institutionalized middle-aged and older population, comparing the Russian-origin population in Estonia with Estonians in Estonia and Russians in Russia in a cross-sectional design. We aim to estimate the (long-term) effects of migration on cognitive functioning in later life, contextualizing the findings in previous research on the healthy migrant effect.Data and methodsWe use data from face-to-face interviews conducted within the SHARE Estonia (2010–2011) and SAGE Russia (2007–2010) surveys. Respondents aged 50+ living in urban areas were grouped by self-identified ethnicity, including 2,365 Estonians, 1,373 Russians in Estonia, and 2,339 Russians in Russia (total N = 6,077). Cognitive functioning was measured using a 25-percentile cut-off threshold for the results of two cognition outcomes - immediate recall and verbal fluency - and the odds of impairment were estimated using binary logistic regression.ResultsRussian men and women living in Estonia have significantly higher odds of impairment in immediate recall than Estonian men and women, though they do not differ from Russians in Russia in the final adjusted models. The differences between all groups are non-significant if age at migration is considered. There are no significant differences between the groups in verbal fluency.ConclusionContrary to the commonly found healthy migrant effect, the middle-aged and older foreign-origin population in Estonia fares initially worse than the native population in the immediate recall outcome, but does not differ from their sending country population, possibly due to Russia’s higher mortality rate and therefore the selective survival of healthier people. Different results depending on the cognitive functioning outcome suggest that migration may affect temporary memory more than crystallized knowledge. However, there are no differences between the groups if defined based on age at migration, which suggests that the age profile differences explain most of the groups’ differences in cognitive functioning.
What Drives the Ionized Gas Outflows in Radio-Quiet AGN?
Authors: Singha Mainak , O’Dea Christopher P. , Baum Stefi A. 
Published: July 2023

We review the mechanisms driving the ionized gas outflows in radio-quiet (RQ) AGN. Although it constitutes ∼90% of the AGN population, what drives these outflows in these AGNs remains an open question. High-resolution imaging and integral field unit (IFU) observation is key to spatially resolving these outflows, whereas radio observations are important to comprehend the underlying radiative processes. Radio interferometric observations have detected linear, collimated structures on the hundreds of pc scale in RQ AGN, which may be very similar to the extended radio jets in powerful galaxies. Proper motions measured in some objects are sub-relativistic. Other processes, such as synchrotron radiation from shock-accelerated gas around the outflows could give rise to radio emissions as well. Near the launching region, these outflows may be driven by the thermal energy of the accretion disk and exhibit free–free emission. IFU observations on the other hand have detected evidence of both winds and jets and the outflows driven by them in radio-quiet AGN. Some examples include nearby AGN such as Mrk 1044 and HE 1353-1917. An IFU study of nearby (z <0.06) RQ AGN has found that these outflows may be related to their radio properties on <100 pc scale, rather than their accretion properties. Recent JWST observations of RQ AGN XID 2028 have revealed that radio jets and wind could inflate bubbles, create cavities, and trigger star formation. Future high-resolution multi-wavelength observations and numerical simulations taking account of both jets and winds are hence essential to understand the complex interaction between radio-quiet AGN and the host from sub-pc to kpc scales.
Identifikasi Dan Kepadatan Sampah Anorganik Di Pantai Ujong Blang Desa Ujong Blang Kecamatan Banda Sakti Kota Lhokseumawe
Authors: Andika Yudho , Pratiwi Bengi , Erniati Erniati , Erlangga Erlangga , Imanullah Imanullah 
Published: July 2023

The phenomenon of marine debris can cause unrest among the community because it can cause marine pollution that affects the activities of coastal communities. This research was conducted with the aim of knowing the type, density and rate of increase of inorganic waste. The research location is at Ujong Blang Beach, Ujong Blang Village, Banda Sakti District, Lhokseumawe City on November 1-13 2021. The method used is purvosive sampling. The waste sampling technique uses a line transect method drawn from the shoreline along the 50 meters in the direction of the coastline and 10 meters towards the sea, in which there are 3 plots measuring 10x10 m2, the distance between the plots is 10 meters. The waste that is taken is waste that is on the substrate, the observed waste is macro-sized inorganic waste. The results showed that the garbage collected at Ujong Blang Beach, Ujong Blang Village, Banda Sakti District, Lhokseumawe City consisted of 5 types, namely plastic, metal, glass, rubber and clothing. Plastic waste has the highest density value, namely 1.59 items/m2 with a relative density value of 95.22%. The highest density value based on the mass of waste is also found in the type of plastic waste, which is 4.64 gr/m2 and a relative density of 78.64 %. The value of the highest rate of increase in waste was on Sunday with a total of 90.5 pieces of waste and a mass of 437.5 g of waste.
Identifikasi dan Uji Penangkapan Radikal 2,2 Difenil-1-Pkrilhidrazil (DPPH) dari Ekstrak Kasar Pigmen Bakteri Simbion Rumput Laut
Authors: Yenusi Tien Nova , Ayer Popy Ida L , Bukorpioper Iriani Ira , Ingratubun Jotje A , Tasak Albida Rante 
Published: July 2023

Abstrak Seaweed belongs to the group of natural antioxidants, these antioxidants are able to counteract free radicals. Secondary metabolites that are antioxidants include alkaloids, flavonoids, phenolic compounds, steroids, and terpenoids and carotenoids. This study aims to identify and test the radical scavenging of 2,2 diphenyl-1-pkrylhydrazyl (DPPH) from the crude extract of the macroalgae symbiont pigment Turbinaria conoides originating from the coastal waters of Hamadi Jayapura, Papua. The method used in this study is an experimental method by identifying pigments using Thin Chromatography (TLC), and for Antioxidant testing using the DPPH Method. The results of the study used the TLC plate Spot 1 on the yellow TLC plate, which had a Retardation frequency (Rf) value of 5/8 = 0.62 and was identified as a carotenoid. The pigment extract of the TC.11 symbiont bacterial pigment extract also has antioxidant potential which was tested by the DPPH method. See the IC50 value of TC.11 bacteria of 24315 ppm compared to the β-carotene marker of 4103 ppm
STRATEGI PENCEGAHAN TINDAK PIDANA KORUPSI PADA PEMILU DAN PILKADA SERENTAK 2024
Authors: DAIRANI, SH., MH. DAIRANI, SH., MH. 
Published: July 2023

Indonesia merupakan negara hukum yang pemerintahannya demokratis di mana semua warga negara mendapatkan hak yang sama dalam pesta demokrasi dengan asas luber jurdil. Namun demikian dalam pelaksaan pemilu banyak terjadi pelanggaran missal politik uang, kekuasaan dan pengaruh kuasa. Penelitian ini bertujuan untuk mengetahui bagaimana strategi yang tepat dalam mengatasi korupsi dalam kegiatan pemilu dan pilkada pada 2024 mendatang. Metode penelitian yuridis normatitf digunakan untuk menyelidiki, menemukan, serta menggambarkan kualitas pada pemilu 2024 mendatang. Pemilu 2019 banyak sekali pelanggaran yang terjadi dan ditemukan 6.649 pelanggar yang melakukan korupsi, berdasarkan data ICW, ada 579 kasus korupsi yang telah ditindak di Indonesia sepanjang 2022. Terdapat strategi dan langgkah dalam memberantas korupsi dalam Pemilu di Indonesia yakni dengan sistem sanksi dan pidana yang sudah diatur dalam UU No. 7 tahun 2017 serta memkasimalkan sanksi pidana bagi politik uang. Dalam upaya mencegah terjadinya politik uang pada pemilu parlemen 2024 mendatang dalam penelitian ini ditawarkan beberapa dari sisi penegakan hukum dan konstitusi yang mencakup batasan dana kampanye baik calon maupun parpol serta larangan bagi mantan terpidana korupsi untuk kembali maju. Sisi yang kedua menitikberatkan pada 3 aspek yaitu penyelenggara pemilu yang independen dan konsisten, parpol yang tidak memberikan rekomendasi terhadap calon yang tidak punya integritas dan kapasitas dan yang terakhir pemilih yang berintegeritas tanpa tergiur dengan politik transaksional yang menjadikan biaya pemilu menjadi mahal
The Infrastructure and Foreign Direct Investment: The Case of Selected Arab Countries
Authors: Alattar Asrar Tareq , Alomari Mohammad Waleed , Malawi Ahmad Ibrahim 
Published: July 2023

Objectives: This study aims to investigate the role of infrastructure in attracting foreign direct investment in selected Arab countries during the period 2007-2019 using annual data. The sample of the study utilizes panel data representing thirteen countries of the Arab region.
Methods: The study employs the ordinary least square (OLS) regression model to analyze the panel data. The study model includes the infrastructure index, trade openness, real GDP growth, and the corruption index as independent variables. At the same time, the net flow of foreign direct investment has been identified as a dependent variable.
Results: The study’s results indicate a direct and statistically significant relationship between infrastructure, GDP growth, and trade openness to FDI flows, while the results indicate a statistically significant inverse relationship between the corruption index to the selected Arab countries.
Conclusions: The study’s variables may be considered important determinants for attracting foreign capital represented by foreign direct investment. Furthermore, Arab countries still need more projects to improve infrastructure quality.
The Future of Problemy Ekorozwoju/ Problems of Sustainable Development Journal
Authors: Pawłowski Artur 
Published: July 2023

In 2023 Problemy Ekorozwoju/ Problems of Sustainable Development turned 18, entering adulthood one could say. The journal debuted on January 1, 2006 as a philosophical journal published only in Polish. From 2008 we begun to publish papers also in English and soon decided to publish only in English. The scope of the journal was expanded and we begun to be multidisciplinary, publishing papers from the humanities, economics and technical sciences (especially environmental engineering).We have always, however, been devoted to sustainable development problematics. Our wider approach offers a chance for Polish scientists to present their research in an international journal (also from the field of humanities, where there are fewer possibilities for international presentations) to foreign scholars and vice versa. Since there are no fees, the journal also is more accessible for scientists from poorer countries. So far we have published 36 numbers (18 issues) with almost 700 scientific papers. From 2010 the journal has been fully indexed in the Web of Science and Scopus. The current IF is 1.1 (in the previous year it was 0.864). Other metrics include: CiteScore (Scopus): 1.9, highest percentile: 57%, Index Copernicus Value ICV: 148.59 and SJR Scimago Journal & Country Rank h-Index: 21. Over the last few years one could observe improvement in all of our international parameters. We have always been an Open Access journal. In recent years we introduced DOI numbers, Open Access Statement and Copyright Rights, Publication Ethics and Malpractice Statement. Soon we will also be visible in the Journal Checker Tool. From this number we are introducing Open Journal System (OJS). Currently the journal has the patronage of the European Academy of Science and Arts (Salzburg, Austria). The publisher is and has always been the Lublin University of Technology (Lublin, Poland).
Analysis and Audit of Reporting on Sustainable Development for Trade Networks and Directions for Their Improvement
Authors: Us Alla , Nazarova Karina 
Published: July 2023

In the modern world, the issue of achieving a sustainable economic development model is becoming more and more urgent. One of its components is compliance with the Goal of sustainable development by companies and verification by state authorities and independent auditors of companies in matters of environmental sustainability. Thus, consideration of modern methods of submission and audit of sustainable development reports (SDR), analysis of opportunities for their improvement becomes relevant. In this work, attention is paid to companies engaged in retail trade, taking into account the peculiarities that they face when submitting the SDR. The purpose of the research was to conduct an analysis of the most common methods of reporting on sustainable development and to develop an effective model (and recommendations for it) for auditing and analyzing sustainable development reporting. Modeling became the main method when writing the paper, taking into account the developed model of analysis and verification of the SDR. The article proposed a new model of verification of non-financial information in sustainability reporting and its graphical display in the audit report. On its basis, it becomes possible to build a new methodology for the audit of the SDR. In addition, the most common international methods of SDR were analyzed, namely the Global Reporting Initiative (GRI), the Sustainability Accounting Standards Board (SASB) and the International Integrated Reporting Council (IIRC). The authors concluded that the GRI is the most universal of the three, while the SASB is focused only on investors. IIRC, being similar to both described above, is an intermediate option. Nevertheless, submission according to the SASB system is the most effective for trade networks, taking into account the peculiarities of the functioning of this type of companies and the level of their influence on the external environment. The results of the conducted research and the data presented in the article make it possible to evaluate the modern methods of submitting financial statements in a new way and provide a basis for building new standards for the audit of these reports.