bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hypophosphatemia in infants with severe bronchiolitis and association with length of mechanical ventilation
Authors: Lusteau Alessandra , Valla Frederic , Javouhey Etienne , Baudin Florent 
Published: June 2023

AbstractObjectivesElectrolyte disorders occurs frequently in children with bronchiolitis. The aim of the present study was to describe the frequency of hypophosphatemia and to evaluate its association with length of mechanical ventilation in infants admitted to a pediatric intensive care unit (PICU) with bronchiolitis.MethodsThis retrospective cohort study included infants aged between 7 days and 3 months admitted to a PICU between September 2018 and March 2020 and diagnosed with severe acute bronchiolitis requiring respiratory support. Infants with a chronic condition that could potentially be a confounding factor were excluded. The primary outcome was the frequency of hypophosphatemia (<1.55 mmol/L); the secondary outcomes were the frequency of hypophosphatemia during the PICU stay, and the association with length of mechanical ventilation (LOMV).ResultsAmong the 319 infants admitted 178 had at least one phosphatemia value and were included in the study. The frequency of hypophosphatemia was 41% at PICU admission (61/148) and 46% during the PICU stay (80/172). The median [IQR] LOMV was significantly longer in children with hypophosphatemia at admission (109 [65–195] h vs. 67 [43–128] h, p = 0.007), and in multivariable linear regression lower phosphatemia at admission was associated with longer LOMV (p < 0.001) after controlling for severity (PELOD2 score) and weight.ConclusionHypophosphatemia was frequent in infants with severe bronchiolitis admitted to a PICU and was associated with a longer LOMV.
Incorporating Chaotropic/Kosmotropic Chemistries onto Plasmonic Nanoheater to Boost Steam Generation Beyond its Photothermal Property
Authors: Chong Carice , Tan Zher Nin , Boong Siew Kheng , Ang Zhi Zhong , Leong Shi Xuan , Lee Yih Hong , Li Haitao , Lee Hiang Kwee 
Published: June 2023

AbstractPhotothermal steam generation promises decentralized water purification, but current methods suffer from slow water evaporation even at high photothermal efficiency of ≈98%. This drawback arises from the high latent heat of vaporization that is required to overcome the strong and extensive hydrogen bonding network in water for steam generation. Here, light‐to‐vapor conversion is boosted by incorporating chaotropic/kosmotropic chemistries onto plasmonic nanoheater to manipulate water intermolecular network at the point‐of‐heating. The chaotropic‐plasmonic nanoheater affords rapid light‐to‐vapor conversion (2.79 kg m−2 h−1 kW−1) at ≈83% efficiency, with the steam generation rate up to 6‐fold better than kosmotropic platforms or emerging photothermal designs. Notably, the chaotropic‐plasmonic nanoheater also lowers the enthalpy of water vaporization by 1.6‐fold when compared to bulk water, signifying that a correspondingly higher amount of steam can be generated with the same energy input. Simulation studies unveil chaotropic surface chemistry is crucial to disrupt water hydrogen bonding network and suppress the energy barrier for water evaporation. Using the chaotropic‐plasmonic nanoheater, organic‐polluted water is purified at ≈100% efficiency, a feat otherwise challenging in conventional treatments. This study offers a unique chemistry approach to boost light‐driven steam generation beyond a material photothermal property.
[Ba4(S2)][ZnGa4S10]: Design of an Unprecedented Infrared Nonlinear Salt‐Inclusion Chalcogenide with Disulfide‐Bonds
Authors: Ding Kaixuan , Wu Hongping , Hu Zhanggui , Wang Jiyang , Wu Yicheng , Yu Hongwei 
Published: June 2023

AbstractSalt‐inclusion chalcogenides (SICs) have been receiving widespread attention due to their large second harmonic generation (SHG) responses and wide bandgaps, however most of them suffer from small birefringence limiting their technical application. Herein, by introducing the π‐conjugated (S2)2− units in the ionic guest of salt‐inclusion structure, the first disulfide‐bond‐containing SIC, [Ba4(S2)][ZnGa4S10] has been synthesized. It exhibits the widest bandgap up to 3.39 eV among polychalcogenides and strong SHG response as large as that of AgGaS2 (AGS). Importantly, its birefringence reaches a max value of 0.053@1064 nm among AGS‐like SICs, indicating it is a promising IR nonlinear optical (NLO) material. Theoretical calculations reveal that the π‐conjugated (S2)2− units and covalent GaS layers favor the enhanced birefringence and large SHG response. This work provides not only a new type of SIC for the first time, but also new lights on the design of IR NLO materials.
Emergence of ATP‐ and GTP‐Binding Aptamers from Single RNA Sequences by Error‐Prone Replication and Selection**
Authors: Wachowius Falk , Porebski Benjamin T. , Johnson Christopher M. , Holliger Philipp 
Published: June 2023

AbstractThe spontaneous emergence of function from diverse RNA sequence pools is widely considered an important transition in the origin of life. Here we show that diverse sequence pools are not a prerequisite for the emergence of function. Starting five independent selection experiments each from a single RNA seed sequence ‐ comprising a central homopolymeric poly‐A (or poly‐U) segment flanked by different conserved primer binding sites ‐ we observe transformation (continuous drift) of the seeds into low diversity sequence pools by mutation, truncation and recombination without ever reaching that of a random pool even after 24 rounds. Upon continuous error prone replication and selection for ATP binding we isolate specific ATP‐ or GTP‐binding aptamers with low micromolar affinities. Our results have implications for early RNA evolution in the light of the high mutation rates associated with both non‐enzymatic and enzymatic prebiotic RNA replication.
Evaluating the influence of environmental and biological factors on migration behavior and residence duration of wild subyearling Chinook Salmon in a fjord estuary using miniature acoustic transmitters
Authors: Lingard Stephanie A. , Bass Arthur L. , Cook Katrina V. , Fortier Michelle , Price Geoffrey G. , Hinch Scott G. 
Published: June 2023

Abstract

Objective
Seaward migration and early marine residence are periods of high mortality in the lifecycle of Pacific salmon Oncorhynchus spp. The conservation of these species requires knowledge of habitat use patterns during early life to address survival bottlenecks. Using new miniaturized transmitters (V3 307-kHz tag; Innovasea Systems), we investigated the association between biological and environmental factors and the residence behavior of subyearling Chinook Salmon Oncorhynchus tshawytscha in a fjord estuary in British Columbia.

Methods
Tagged wild subyearling Chinook Salmon (n = 49; 67–95 mm) were experimentally released into an estuary. Using time-to-event analysis and model selection, we evaluated the association between biological (size, growth, day of release) and environmental (temperature, salinity, depth, discharge, tide direction) factors and estuary residence patterns.

Result
Of the 49 fish released, 36 were inferred to have exited the estuary successfully. In this sample of subyearling Chinook Salmon, the median residence duration was estimated to be 11.2 days (95% CI = 6.5–15.5). We found tide direction and salinity to be important factors influencing the probability of a fish leaving the estuary. Fish were 75% more likely to leave the estuary on an ebb tide. Higher salinity also increased the probability of a fish leaving the estuary. Fish successful in leaving the estuary displayed either direct or indirect movement patterns in the estuary, with most fish (71%) being indirect movers that made multiple trips upstream and downstream. Within the estuary, most movements occurred at night (76%), regardless of tide direction.

Conclusion
This study provides the first direct measure of estuary residence duration in wild subyearling Chinook Salmon and a valuable description of movement ecology in this age-class of fish. While this was a small study in a single year, our results indicate this estuary is likely a stopover habitat for larger subyearlings. Studies indicating the use of habitats by specific populations, as presented here, are integral to the design of habitat-based conservation measures for mobile species.
Ultrasonographic features of a histologically confirmed pilomatricoma in a dog
Authors: Fenet Marion , Zacharopoulou Maria , Garapin Bénédicte , Delverdier Maxence , Layssol‐Lamour Catherine 
Published: June 2023

AbstractA 6‐year‐old, neutered, crossbreed, female dog was presented for a well‐defined subcutaneous mass on the head evolving for a year. An ultrasound exam revealed a well‐circumscribed, oval, heterogeneous and hyperechoic soft tissue mass, with hyperechoic internal foci, a hypoechoic peripheral rim, a cystic fluid component and a high vascularisation in colour Doppler. An isolated hair was also detected and removed from the fluid component. The mass was sampled and histological examination suggested a benign pilomatricoma. The owner declined further investigation and complete resection of the mass. This is the first report of ultrasonographic features of a pilomatricoma in a dog.
Different presentations of unerupted canine teeth in three juvenile dogs
Authors: Feuer Rebecca , Mulherin Brenda L. 
Published: June 2023

AbstractCanine teeth should show evidence of eruption by the time a dog is 7 months old. Before 7 months of age, unerupted teeth in juvenile patients can often be overlooked due to varying eruption patterns. However, if a tooth has not demonstrated evidence of eruption by 7 months of age, it is considered abnormal. Differentials for unerupted teeth include congenital abnormalities causing tooth absence (anodontia, oligodontia or hypodontia), traumatic loss of a tooth and impaction of the tooth beneath either the gingiva or the alveolar bone and the gingiva. This case series explores three different presentations of unerupted teeth in juvenile dogs. All three dogs were under 10 months of age when they presented for evaluation and treatment.
Support for nonlead shot for dove hunting in Illinois
Authors: Ellis Matthew B. , Miller Craig A. , Vaske Jerry J. 
Published: June 2023

AbstractMourning doves are the most hunted game species in the United States. Mourning dove populations are declining, and the continued use of lead shot has been cited as one contributory factor. We examined the relationship between support for a ban on lead shot when dove hunting and 3 sets of variables: (1) beliefs about lead and steel shot, (2) prior dove hunting experiences, and (3) hunter demographics. Data were obtained from a mailed survey of 4,330 dove hunters in Illinois (response rate = 59%). Our results indicated that 81% of respondents were opposed to restrictions on the use of lead shot and these individuals believed that lead ammunition did not pose a risk to wildlife and that steel shot was less effective than lead shot. Supporters of banning lead shot were almost twice as likely to use steel shot, reported 2 fewer years hunting doves, went dove hunting 75% as much, and harvested 2/3 as many doves as those who opposed a ban. Consistent with social‐psychological theory, beliefs were the best predictors of whether an individual supported or opposed a ban, followed by dove hunting experiences and demographic variables.
Antillean manatee calves in captive rehabilitation change vocal behavior in anticipation of feeding
Authors: Ramos Eric Angel , Brady Beth , Lasala Jake Andrew , Liebschner Angus , Obbink Sander , Walker Zoe , Rebello Maegan , Magnasco Marcelo O. 
Published: June 2023

AbstractCaptive animals typically develop anticipatory behaviors, actions of increased frequency done in anticipation of an event such as feeding. Anticipatory behaviors can be an indicator of an animal's welfare. However, for rehabilitating animals that are expected to be reintroduced into the wild, these behaviors need to be extinguished to ensure successful release. Scheduled activities such as feeding occur daily and vocalizations could potentially be used to identify anticipatory behavior. Here, we tested the hypothesis that manatee calves modify their vocal production rate as a form of anticipatory behavior. Vocalizations of two Antillean manatee (Trichechus manatus manatus) calves were recorded for 10 min before, during, and after feeding sessions at Wildtracks, a manatee rehabilitation center in Belize. The number of calls were counted across recording sessions and three acoustic parameters were measured from calls including duration, frequency modulation, and center frequency. A repeated measures ANOVA comparing the number of calls across sessions indicated manatees produced significantly more calls before feeding sessions than during and after sessions. In addition, manatees increased the duration and lowered the frequency of calls before feeding sessions. This information can give further insight on ways to improve rehabilitation protocols and manage human interactions to increase the overall survival rate of rehabilitated manatees when released back into the wild.
Why Am I Waiting? Data-Driven Analysis of Waiting Times in Business Processes
Authors: Lashkevich Katsiaryna , Milani Fredrik , Chapela-Campa David , Suvorau Ihar , Dumas Marlon 
Published: June 2023

AbstractWaiting times in a business process often arise when a case transitions from one activity to another. Accordingly, analyzing the causes of waiting times of activity transitions can help analysts to identify opportunities for reducing the cycle time of a process. This paper proposes a process mining approach to decompose the waiting time observed in each activity transition into multiple direct causes and to analyze the impact of each identified cause on the cycle time efficiency of the process. An empirical evaluation shows that the proposed approach is able to discover different direct causes of waiting times. The applicability of the proposed approach is demonstrated in a real-life process.
A Case Study on the Impact of Forensic-Ready Information Systems on the Security Posture
Authors: Daubner Lukas , Matulevičius Raimundas , Buhnova Barbora , Antol Matej , Růžička Michal , Pitner Tomas 
Published: June 2023

AbstractWhile approaches aimed at developing forensic-ready systems are starting to emerge, it is still primarily a theoretical concept. This paper presents a case study of integrating forensic readiness capabilities into SensitiveCloud, an information system for storing and processing sensitive data. A risk-based approach to forensic readiness design is followed to achieve it. Consequently, weaknesses in both processes and systems are identified, and forensic readiness requirements are formulated. This case study reports on lessons learned in a practical implementation of a forensic-ready system, its impact on security, and its support towards ISO/IEC 27k.
Building Collaborative Cybersecurity for Critical Infrastructure Protection: Empirical Evidence of Collective Intelligence Information Sharing Dynamics on ThreatFox
Authors: Jollès Eric , Gillard Sébastien , Percia David Dimitri , Strohmeier Martin , Mermoud Alain 
Published: June 2023

AbstractThis article describes three collective intelligence dynamics observed on ThreatFox, a free platform operated by abuse.ch that collects and shares indicators of compromise. These three dynamics are empirically analyzed with an exclusive dataset provided by the sharing platform. First, participants’ onboarding dynamics are investigated and the importance of building collaborative cybersecurity on an established network of trust is highlighted. Thus, when a new sharing platform is created by abuse.ch, an existing trusted community with ’power users’ will migrate swiftly to it, in order to enact the first sparks of collective intelligence dynamics. Second, the platform publication dynamics are analyzed and two different superlinear growths are observed. Third, the rewarding dynamics of a credit system is described - a promising incentive mechanism that could improve cooperation and information sharing in open-source intelligence communities through the gamification of the sharing activity. Overall, our study highlights future avenues of research to study the institutional rules enacting collective intelligence dynamics in cybersecurity. Thus, we show how the platform may improve the efficiency of information sharing between critical infrastructures, for example within Information Sharing and Analysis Centers using ThreatFox. Finally, a broad agenda for future empirical research in the field of cybersecurity information sharing is presented - an important activity to reduce information asymmetry between attackers and defenders.
Themenkarten für die Praxis, aus der Theorie
Authors: Locher Maximilian , Thomas Martina , Baecker Dirk , März Anna 
Published: June 2023

Zusammenfassung
Der Beitrag erläutert die im KILPaD-Projekt verwendeten Begriffe Organisation, Digitalisierung, Schnittstellenanalyse, Vision, Arbeit, Netzwerkorganisation, Oberflächen, Akzeptanz, Lernen, Innovation, Human und agil mit knappen Definitionen und Schaubildern. Er versucht, begriffliche Präzision mit anregender Reflexion zu verbinden. Keins der Themen ist abschließend zu behandeln. Jedes einzelne ist ein Türöffner für die Betrachtung von Veränderung.
Synthetic CTs for MRI-only brain RT treatment: integration of immobilization systems
Authors: Masitho Siti , Grigo Johanna , Brandt Tobias , Lambrecht Ulrike , Szkitsak Juliane , Weiss Alexander , Fietkau Rainer , Putz Florian , Bert Christoph 
Published: June 2023

Abstract
Purpose
Auxiliary devices such as immobilization systems should be considered in synthetic CT (sCT)-based treatment planning (TP) for MRI-only brain radiotherapy (RT). A method for auxiliary device definition in the sCT is introduced, and its dosimetric impact on the sCT-based TP is addressed.

Methods
T1-VIBE DIXON was acquired in an RT setup. Ten datasets were retrospectively used for sCT generation. Silicone markers were used to determine the auxiliary devices’ relative position. An auxiliary structure template (AST) was created in the TP system and placed manually on the MRI. Various RT mask characteristics were simulated in the sCT and investigated by recalculating the CT-based clinical plan on the sCT. The influence of auxiliary devices was investigated by creating static fields aimed at artificial planning target volumes (PTVs) in the CT and recalculated in the sCT. The dose covering 50% of the PTV (D50) deviation percentage between CT-based/recalculated plan (∆D50[%]) was evaluated.

Results
Defining an optimal RT mask yielded a ∆D50[%] of 0.2 ± 1.03% for the PTV and between −1.6 ± 3.4% and 1.1 ± 2.0% for OARs. Evaluating each static field, the largest ∆D50[%] was delivered by AST positioning inaccuracy (max: 3.5 ± 2.4%), followed by the RT table (max: 3.6 ± 1.2%) and the RT mask (max: 3.0 ± 0.8% [anterior], 1.6 ± 0.4% [rest]). No correlation between ∆D50[%] and beam depth was found for the sum of opposing beams, except for (45° + 315°).

Conclusion
This study evaluated the integration of auxiliary devices and their dosimetric influence on sCT-based TP. The AST can be easily integrated into the sCT-based TP. Further, we found that the dosimetric impact was within an acceptable range for an MRI-only workflow.
Radiosurgery for ventricular tachycardia (RAVENTA): interim analysis of a multicenter multiplatform feasibility trial
Authors: Krug David , Zaman Adrian , Eidinger Lina , Grehn Melanie , Boda-Heggemann Judit , Rudic Boris , Mehrhof Felix , Boldt Leif-Hendrik , Hohmann Stephan , Merten Roland , Buergy Daniel , Fleckenstein Jens , Kluge Anne , Rogge Annette , Both Marcus , Rades Dirk , Tilz Roland Richard , Olbrich Denise , König Inke R. , Siebert Frank-Andre , Schweikard Achim , Vonthein Reinhard , Bonnemeier Hendrik , Dunst Jürgen , Blanck Oliver 
Published: June 2023

Abstract
Background
Single-session cardiac stereotactic radiation therapy (SBRT) has demonstrated promising results for patients with refractory ventricular tachycardia (VT). However, the full safety profile of this novel treatment remains unknown and very limited data from prospective clinical multicenter trials are available.

Methods
The prospective multicenter multiplatform RAVENTA (radiosurgery for ventricular tachycardia) study assesses high-precision image-guided cardiac SBRT with 25 Gy delivered to the VT substrate determined by high-definition endocardial and/or epicardial electrophysiological mapping in patients with refractory VT ineligible for catheter ablation and an implanted cardioverter defibrillator (ICD). Primary endpoint is the feasibility of full-dose application and procedural safety (defined as an incidence of serious [grade ≥ 3] treatment-related complications ≤ 5% within 30 days after therapy). Secondary endpoints comprise VT burden, ICD interventions, treatment-related toxicity, and quality of life. We present the results of a protocol-defined interim analysis.

Results
Between 10/2019 and 12/2021, a total of five patients were included at three university medical centers. In all cases, the treatment was carried out without complications. There were no serious potentially treatment-related adverse events and no deterioration of left ventricular ejection fraction upon echocardiography. Three patients had a decrease in VT episodes during follow-up. One patient underwent subsequent catheter ablation for a new VT with different morphology. One patient with local VT recurrence died 6 weeks after treatment in cardiogenic shock.

Conclusion
The interim analysis of the RAVENTA trial demonstrates early initial feasibility of this new treatment without serious complications within 30 days after treatment in five patients. Recruitment will continue as planned and the study has been expanded to further university medical centers.

Trial registration number
NCT03867747 (clinicaltrials.gov). Registered March 8, 2019. Study start: October 1, 2019.
Characteristics and Risk Assessment of Microplastics in Water and Mussels Sampled from Cape Town Harbour and Two Oceans Aquarium, South Africa
Authors: Sparks Conrad , Viljoen Nathalie , Hill Deen , Lassen Jonathan , Awe Adetunji 
Published: June 2023

AbstractThe aim of this study was to measure the characteristics and risk assessment of microplastics (MPs) in Cape Town Harbour (CTH) and the Two Oceans Aquarium (TOA) in Cape Town, South Africa from 2018 to 2020. Water and mussel MP samples were analyzed at 3 sites in CTH and TOA, respectively. Microplastics were mainly filamentous, black/grey and 1000–2000 μm in size. A total of 1778 MPs, averaging 7.50 (± 0.6 standard error of the mean, SEM) MPs/unit were recorded. Average MP concentrations were 10.3 ± 1.1 MPs/L in water and 6.27 ± 0.59 MPs/individual or, based on weight, 3.05 ± 1.09 MPs/g soft tissue wet weight in mussels. Average MPs in seawater in CTH (12.08 ± 1.3 SEM MPs/L) was significantly higher (4.61 ± 1.1 MPs/L) than inside the TOA (U = 536, p = 0.04). Various risk assessment calculations indicate that MPs in seawater poses a greater ecological risk than MPs in mussels at the sites sampled.