bluuebunny/crossref_metadata_2025_split huggingface dataset:
The PEPSI Exoplanet Transit Survey (PETS)
Authors: Scandariato G. , Borsa F. , Bonomo A. S. , Gaudi B. S. , Henning Th. , Ilyin I. , Johnson M. C. , Malavolta L. , Mallonn M. , Molaverdikhani K. , Nascimbeni V. , Patience J. , Pino L. , Poppenhaeger K. , Schlawin E. , Shkolnik E. L. , Sicilia D. , Sozzetti A. , Strassmeier K. G. , Veillet C. , Wang J. , Yan F. 
Published: April 2023

Context. Hot giant planets such as MASCARA-1 b are expected to have thermally inverted atmospheres, which makes them perfect laboratories for atmospheric characterization through high-resolution spectroscopy. Nonetheless, previous attempts at detecting the atmosphere of MASCARA-1 b in transmission have led to negative results.
Aims. We aim to detect the optical emission spectrum of MASCARA-1 b.
Methods. We used the high-resolution spectrograph PEPSI to observe MASCARA-1 (spectral type A8) near the secondary eclipse of the planet. We cross-correlated the spectra with synthetic templates computed for several atomic and molecular species.
Results. We detect Fe I, Cr I, and Ti I in the atmosphere of MASCARA-1 b with a S/N ≈ 7, 4, and 5, respectively, and confirm the expected systemic velocity of ≈13 km s−1 and the radial velocity semi-amplitude of MASCARA-1 b of ≈200 km s−1. The detection of Ti is of particular importance in the context of the recently proposed phenomenon of Ti cold-trapping below a certain planetary equilibrium temperature.
Conclusions. We confirm the presence of an atmosphere around MASCARA-1 b through emission spectroscopy. We conclude that the atmospheric non-detection in transmission spectroscopy is due to the strong gravity of the planet and/or to the overlap between the planetary track and its Doppler shadow.
Reactions of Benzylboronate Nucleophiles
Authors: Barker Timothy J. , Bogatkevich Andrew , Crowder Dallas W. , Gierszal Sophia G. , Hayes Jacob C. , Hollerbach Michael R. , Russell Richard W. 
Published: April 2023

AbstractThis short review summarizes our laboratory’s development of benzylboronic esters as nucleophiles. Activation of the benzylboronic ester is achieved by irreversible coordination of an alkyllithium Lewis base to form a nucleophilic benzylboronate. This boronate was found to react with aldehydes, imines, ketones, and alkyl bromides. A copper catalyst was employed in reactions of the boronate with epoxides and aziridines.1	Introduction2	1,2-Additions3	Additions to sp3 Electrophiles4	Conclusion and Outlook
Palladium-Catalyzed Asymmetric Cycloaddition/Cope Rearrangement Relay: Synthesis of Chiral Endocyclic Allenes
Authors: Lu Liang-Qiu , Shi Bin , Xiao Wen-Jing 
Published: April 2023

AbstractThe synthesis of chiral endocyclic allenes, especially the medium-sized ones, remains a challenge in allene chemistry due to unfavorable tension and difficult stereocontrol. Herein, an efficient protocol for the construction of chiral nine-membered endocyclic allenes via palladium-catalyzed asymmetric cycloaddition/Cope rearrangement relay of vinyl carbonates with activated enynes is highlighted. This process provides rapid access to a variety of chiral nine-membered endocyclic allenes in good yields with excellent enantioselectivities. In particular, a chiral P,S-ligand shows good performance on stereoinduction, generating central and axial chirality in a single transformation, which is rationalized by DFT calculations and by a proposed transition state.1	Introduction2	Pd-Catalyzed Asymmetric Cycloaddition/Cope Rearrangement Relay3	Plausible Mechanism and Stereochemical Outcome4	Conclusion and Outlook
Management of Dysplasia in Inflammatory Bowel Disease
Authors: Rubens Merrill , Smith Radhika 
Published: April 2023

AbstractGiven the chronic nature of mucosal inflammation present in patients with inflammatory bowel disease (IBD), there is a high risk of dysplastic lesions progressing to cancer, in addition to a high risk of synchronous and/or metachronous cancers developing in those diagnosed with dysplasia. Due to this, consensus guidelines recommend regular surveillance. When visible dysplasia is encountered, options include endoscopic or surgical resection depending on characteristics of the lesion. Advancements in endoscopic tools increasingly allow for endoscopic removal when appropriate. Invisible dysplasia discovered on random biopsy should prompt referral to physicians who specialize in IBD. While surgical resection with proctocolectomy significantly decreases the risk of colorectal cancer, the risk must be balanced against the morbidity of surgery and quality-of-life concerns. Management of dysplasia in IBD patients requires complex decision-making that requires balance of patient values and goals of care with cancer-related risk factors.
Nonoperative Management of dMMR/MSI-H Colorectal Cancer following Neoadjuvant Immunotherapy: A Narrative Review
Authors: Xiao Binyi , Yu Jiehai , Ding Pei-Rong 
Published: April 2023

AbstractImmunotherapy with PD-1 blockade has achieved a great success in colorectal cancers (CRCs) with high microsatellite instability (MSI-H) and deficient mismatch repair (dMMR), and has become the first-line therapy in metastatic setting. Studies of neoadjuvant immunotherapy also report exciting results, showing high rates of clinical complete response (cCR) and pathological complete response. The high efficacy and long duration of response of immunotherapy has prompt attempts to adopt watch-and-wait strategy for patients achieving cCR following the treatment. Thankfully, the watch-and-wait approach has been proposed for nearly 20 years for patients undergoing chemoradiotherapy and has gained ground among patients as well as clinicians. In this narrative review, we combed through the available information on immunotherapy for CRC and on the watch-and-wait strategy in chemoradiotherapy, and looked forward to a future where neoadjuvant immunotherapy as a curative therapy would play a big part in the treatment of MSI-H/dMMR CRC.
The Progress of Colorectal Polyposis Syndrome in Chinese Population
Authors: Yuan Zhijun , Yang Mengyuan , Yuan Ying 
Published: April 2023

AbstractThe pathogenesis, clinical phenotype, treatment strategy, and family management of hereditary tumor syndromes are different from those of sporadic tumors. Nearly a quarter of patients with colorectal cancer show significant familial aggregation and genetic predisposition, and 5 to 10% are associated with definite genetic factors. According to the clinical phenotype, it can be divided into nonpolyposis syndrome and polyposis syndrome. Among the polyposis syndrome patients with definite clinical symptoms, there are still some patients with unknown etiology (especially attenuated familial adenomatous polyposis), which is a difficult problem in clinical diagnosis and treatment. Therefore, for this rare disease, it is urgent to carry out multicenter studies, complete the gene variation spectrum, explore new pathogenic factors, and accumulate clinical experience. This article mainly introduces the research progress and related work of colorectal polyposis syndrome in China.
Targeting the Contact Pathway of Coagulation for the Prevention and Management of Medical Device-Associated Thrombosis
Authors: Goel Abhishek , Tathireddy Harsha , Wang Si-Han , Vu Helen H. , Puy Cristina , Hinds Monica T. , Zonies David , McCarty Owen J.T. , Shatzel Joseph J. 
Published: April 2023

AbstractHemorrhage remains a major complication of anticoagulants, with bleeding leading to serious and even life-threatening outcomes in rare settings. Currently available anticoagulants target either multiple coagulation factors or specifically coagulation factor (F) Xa or thrombin; however, inhibiting these pathways universally impairs hemostasis. Bleeding complications are especially salient in the medically complex population who benefit from medical devices. Extracorporeal devices—such as extracorporeal membrane oxygenation, hemodialysis, and cardiac bypass—require anticoagulation for optimal use. Nonetheless, bleeding complications are common, and with certain devices, highly morbid. Likewise, pharmacologic prophylaxis to prevent thrombosis is not commonly used with many medical devices like central venous catheters due to high rates of bleeding. The contact pathway members FXI, FXII, and prekallikrein serve as a nexus, connecting biomaterial surface-mediated thrombin generation and inflammation, and may represent safe, druggable targets to improve medical device hemocompatibility and thrombogenicity. Recent in vivo and clinical data suggest that selectively targeting the contact pathway of coagulation through the inhibition of FXI and FXII can reduce the incidence of medical device-associated thrombotic events, and potentially systemic inflammation, without impairing hemostasis. In the following review, we will outline the current in vivo and clinical data encompassing the mechanism of action of drugs targeting the contact pathway. This new class of inhibitors has the potential to herald a new era of effective and low-risk anticoagulation for the management of patients requiring the use of medical devices.
47.1.2.1.6 Alkyl-Mizoroki–Heck-Type Reactions
Authors: Lei A. , Tang S. 
Published: April 2023

AbstractSubstituted alkenes are basic structural motifs in a large number of organic molecules and their synthesis has received continuous attention from synthetic chemists. One of the most straightforward methods for constructing substituted alkenes is the Mizoroki–Heck reaction. Generally, this transformation is catalyzed by palladium and mainly deals with the synthesis of substituted alkenes from aryl or vinyl electrophiles. In sharp contrast, the Mizoroki–Heck reaction of alkyl electrophiles has long been considered a challenging transformation due to the decreased rates of oxidative addition and subsequent facile β-hydride elimination. To address this limitation in traditional Mizoroki–Heck reactions, radical processes have been introduced to achieve the alkenylation of alkyl electrophiles. This review provides an overview of the recent developments in alkyl-Mizoroki–Heck-type reactions. Particular attention is paid to the intermolecular Mizoroki–Heck-type reaction between alkyl radicals and terminal alkenes. The limitations and advantages of using different catalytic methods are discussed and compared.
Spurring and sustaining online consumer activism: the role of cause support and brand relationship in microlevel action frames
Authors: Muraro Iago S. , Thorson Kjerstin , Huddleston Patricia T. 
Published: April 2023

AbstractResearch suggests that social media consumer activism can be motivated through multiple microlevel action frames (MAFs – or simply, microframes). In this study, we examine an online consumer activism campaign against the supermarket chain Carrefour in Brazil and develop a typology of microframes that emerged during this episode of consumer activism. We leverage Twitter data to illustrate the distinction between cause-oriented (centered on animal rights issues) and brand-oriented MAFs (emphasizing consumer disappointment in Carrefour) and examine their influence on the emergence of other online consumer activism microframes. Our findings reveal the complex interplay between cause support (cause-oriented MAF) and perceptions of a brand transgression (brand-oriented MAF) to galvanize collective action. We theorize the roles of distinct MAFs in spurring and sustaining consumers’ online mobilization. Practical recommendations for brand managers are discussed.
Nucleation and growth of crystalline ices from amorphous ices
Authors: Tonauer Christina M. , Fidler Lilli-Ruth , Giebelmann Johannes , Yamashita Keishiro , Loerting Thomas 
Published: April 2023

We here review mostly experimental and some computational work devoted to nucleation in amorphous ices. In fact, there are only a handful of studies in which nucleation and growth in amorphous ices are investigated as two separate processes. In most studies, crystallization temperatures Tx or crystallization rates RJG are accessed for the combined process. Our Review deals with different amorphous ices, namely, vapor-deposited amorphous solid water (ASW) encountered in many astrophysical environments; hyperquenched glassy water (HGW) produced from μm-droplets of liquid water; and low density amorphous (LDA), high density amorphous (HDA), and very high density amorphous (VHDA) ices produced via pressure-induced amorphization of ice I or from high-pressure polymorphs. We cover the pressure range of up to about 6 GPa and the temperature range of up to 270 K, where only the presence of salts allows for the observation of amorphous ices at such high temperatures. In the case of ASW, its microporosity and very high internal surface to volume ratio are the key factors determining its crystallization kinetics. For HGW, the role of interfaces between individual glassy droplets is crucial but mostly neglected in nucleation or crystallization studies. In the case of LDA, HDA, and VHDA, parallel crystallization kinetics to different ice phases is observed, where the fraction of crystallized ices is controlled by the heating rate. A key aspect here is that in different experiments, amorphous ices of different “purities” are obtained, where “purity” here means the “absence of crystalline nuclei.” For this reason, “preseeded amorphous ice” and “nuclei-free amorphous ice” should be distinguished carefully, which has not been done properly in most studies. This makes a direct comparison of results obtained in different laboratories very hard, and even results obtained in the same laboratory are affected by very small changes in the preparation protocol. In terms of mechanism, the results are consistent with amorphous ices turning into an ultraviscous, deeply supercooled liquid prior to nucleation. However, especially in preseeded amorphous ices, crystallization from the preexisting nuclei takes place simultaneously. To separate the time scales of crystallization from the time scale of structure relaxation cleanly, the goal needs to be to produce amorphous ices free from crystalline ice nuclei. Such ices have only been produced in very few studies.
A genome-wide optical pooled screen reveals regulators of cellular antiviral responses
Authors: Carlson Rebecca J. , Leiken Michael D. , Guna Alina , Hacohen Nir , Blainey Paul C. 
Published: April 2023

The infection of mammalian cells by viruses and innate immune responses to infection are spatiotemporally organized processes. Cytosolic RNA sensors trigger nuclear translocation of the transcription factor interferon regulatory factor 3 (IRF3) and consequent induction of host immune responses to RNA viruses. Previous genetic screens for factors involved in viral sensing did not resolve changes in the subcellular localization of host or viral proteins. Here, we increased the throughput of our optical pooled screening technology by over fourfold. This allowed us to carry out a genome-wide CRISPR knockout screen using high-resolution multiparameter imaging of cellular responses to Sendai virus infection coupled with in situ cDNA sequencing by synthesis (SBS) to identify 80,408 single guide RNAs (sgRNAs) in 10,366,390 cells—over an order of magnitude more genomic perturbations than demonstrated previously using an in situ SBS readout. By ranking perturbations using human-designed and deep learning image feature scores, we identified regulators of IRF3 translocation, Sendai virus localization, and peroxisomal biogenesis. Among the hits, we found that ATP13A1, an ER-localized P5A-type ATPase, is essential for viral sensing and is required for targeting of mitochondrial antiviral signaling protein (MAVS) to mitochondrial membranes where MAVS must be localized for effective signaling through retinoic acid-inducible gene I (RIG-I). The ability to carry out genome-wide pooled screens with complex high-resolution image-based phenotyping dramatically expands the scope of functional genomics approaches.
Interdisciplinary practice in performance sport: A scoping review of evidence of collaboration
Authors: Burns Andrew , Collins Dave 
Published: April 2023

ABSTRACTPerformance support teams are increasingly comprised of sub‐disciplines, bringing varied expertise to support an athlete or team in achieving the desired result. With more voices in the room, however, there is a need to investigate how these individuals can effectively work together collaboratively. Accordingly, the present study reviewed empirical articles that have examined interdisciplinary practice in performance sport. In total, 22 articles met the full inclusion criteria. We discuss the four key themes that emerged from the literature linked to these contexts: namely, Theoretical frameworks, Facilitative leadership and culture, Organisational and logistical structure and processes, and Personal and interpersonal qualities. To deepen the understanding in this intricate field, conducting future research such as longitudinal studies that follow team working practices over time and delve into the lived experiences of teams, as well as the perspectives of various stakeholders, would be beneficial.
Visually clear diffusive light panel with embedded semi-reflective rough-surface planar outcouplers
Authors: Park Hongbae , Stoeber Boris 
Published: April 2023

Abstract
We present a visually transparent light-diffusing panel in the form of a light guide, which has semi-reflective, thin-film blades buried within it acting as diffusive outcouplers. The semi-reflective blades can be tilted relative to the length of the light guide and are textured to partially scatter the light incident upon them in the reflection domain, while transmitting the rest. We show that the texturization of the outcouplers can be achieved following a simple molding process using a mold with well-defined roughness regions to subsequently create light-scattering surfaces. The mold is either based on frosted glass or on a photolithographic process using a polymer photomask. We demonstrate with a prototype that the view through the textured outcouplers is visually clear. Also, we demonstrate that by varying the angular difference between the incidence of the propagating light rays and the outcoupler angle, the ratio of the amount of diffused light emanating from the two surfaces of the light guide can be biased from ∼1:2 to ∼1:20. The proposed device can be used as a transparent light source that provides an occlusion-free and undistorted see-through view.
Sonication-assisted liquid exfoliation and size-dependent properties of magnetic two-dimensional α-RuCl3
Authors: Synnatschke Kevin , Jonak Martin , Storm Alexander , Laha Sourav , Köster Janis , Petry Julian , Ott Steffen , Szydłowska Beata , Duesberg Georg S , Kaiser Ute , Klingeler Rüdiger , Lotsch Bettina V , Backes Claudia 
Published: April 2023

Abstract
Originating from the hexagonal arrangement of magnetic ions in the presence of strong spin orbit coupling, α-RuCl3 is considered as model system for the Kitaev-Heisenberg model. While the magnetic properties of α-RuCl3 have been studied in bulk single crystals or micromechanically-exfoliated nanosheets, little is known about the nanosheets’ properties after exfoliation by techniques suitable for mass production such as liquid phase exfoliation (LPE). Here, we demonstrate sonication-assisted LPE on α-RuCl3 single crystals in an inert atmosphere. Coupled with centrifugation-based size selection techniques, the accessible size- and thickness range is quantified by statistical atomic force microscopy. Individual nanosheets obtained after centrifugation-based size selection are subjected to transmission electron microscopy to confirm their structural integrity after the exfoliation. The results are combined with bulk characterisation methods, including Raman and x-ray photoelectron spectroscopy, and powder diffraction experiments to evaluate the structural integrity of the nanosheets. We report changes of the magnetic properties of the nanomaterial with nanosheet size, as well as photospectroscopic metrics for the material concentration and average layer number. Finally, a quantitative analysis on environmental effects on the nanomaterial integrity is performed based on time and temperature dependent absorbance spectroscopy revealing a relatively slow decay (half-life of ∼2000 h at 20 °C), albeit with low activation energies of 6–20 kJ mol−1.
Nanoscale morphology tailoring in plasma deposited CN
x
layers
Authors: Vasin Andrii , Slobodian Olexander , Rusavsky Andrii , Gudymenko Olexander , Lytvyn Petro , Tiagulskyi Stanislav , Yatskiv Roman , Grym Jan , Bortchagovsky Eugene , Dzhagan Volodymyr , Zahn Dietrich , Nazarov Alexei 
Published: April 2023

Abstract
Magnetron discharge plasma was applied for the synthesis of CN
x
thin layers using methane and nitrogen gas precursors. The incorporation of nitrogen in the carbon network resulted in the dramatic evolution of growth morphology: from a ‘buried’ porous layer observed at low nitrogen incorporation to aligned bundles of nanorods grown perpendicular to the substrate surface at maximum discharge power and nitrogen flow. The films deposited at the low discharge power and high nitrogen incorporation exhibited a mesoporous sponge-like morphology after vacuum annealing. Relevant physical mechanisms responsible for the formation of nano- and mesoshaped morphology are discussed in terms of the effects of internal mechanical stresses and plasma etching. In addition, the sensing properties of the sponge-like layer were preliminarily examined in water vapor and ammonia ambients. The CN
x
films showed enhanced sensitivity to ammonia and reverse electrical response to moisture in comparison with a nitrogen-free nanoporous carbon film, which were assigned to modification of the electronic properties of the nitridated surface.
Optimal periodicity-enhanced group sparse for bearing incipient fault feature extraction
Authors: Zhang Sicheng , Jiang Hongkai , Yao Renhe , Zhu Hongxuan 
Published: April 2023

Abstract
Efficient and automatic fault feature extraction of rotating machinery, especially for incipient faults is a challenging task of great significance. In this article, an optimal periodicity-enhanced group sparse method is proposed. Firstly, a period sequence determination method without any prior information is proposed, and the amplitude is calculated by the numerical characteristics of the vibration signal to obtain period square waves. Secondly, the periodic square waves are embedded into the group sparse algorithm, to eliminate the influence of random impulses, and intensify the periodicity of the acquisition signal. Thirdly, a fault feature indicator reflecting both signal periodicity and sparsity within and across groups is proposed as the fitness of the marine predator algorithm for parameter automatic selection. In addition, the method proposed is evaluated and compared by simulation and experiment. The results show that it can effectively extract incipient fault features and outperforms traditional overlapping group shrinkage and Fast Kurtogram.