bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ce‐Induced Differentiated Regulation of Co Sites via Gradient Orbital Coupling for Bifunctional Water‐Splitting Reactions
Authors: Li Meng , Wang Xuan , Liu Kun , Zhu Zhuoya , Guo Hanyu , Li Meize , Du Han , Sun Dongmei , Li Hao , Huang Kai , Tang Yawen , Fu Gengtao 
Published: June 2023

AbstractRare‐earth (RE) elements have emerged as crucial promoters to regulate the electrocatalysis of transition metals (TM), but knowledge about the RE‐enhanced mechanism of TM in electrocatalysis is limited. Herein, an array‐like Ce‐CoP catalyst is constructed to explore the origin and distinction of the Ce‐induced enhanced mechanism of Co sites in both the hydrogen evolution reaction (HER) and the oxygen evolution reaction (OER). Compared with individual CoP, the developed Ce‐CoP exhibits superior bifunctional electrocatalytic activity with the overpotentials of 81 and 240 mV at 10 mA cm−2, respectively for HER and OER, with excellent electrocatalytic stability. Theoretical calculations show that the unique 4f valence electron structure of Ce endows the Co sites with differentiated regulation in the HER and OER through f‐p‐d gradient orbital coupling. In the HER, the retained Ce‐4f state induces electron spin parallelism at the surrounding Co sites, promoting the adsorption of *H intermediates. While in the OER, the Ce‐4f band acts as sacrificing band to protect the Co sites from overoxidation through the Ce‐O‐Co chain with an optimized Co‐3d state, providing additional spin coupling with oxygen intermediates. These findings provide new insights into comprehending the RE‐enhanced mechanism of electrocatalysis and present valuable design guidelines for the development of efficient multi‐functional electrocatalysts.
Active Site Tailoring of Metal‐Organic Frameworks for Highly Efficient Oxygen Evolution
Authors: Hu Feng , Yu Deshuang , Zeng Wen‐Jing , Lin Zih‐Yi , Han Silin , Sun Yajie , Wang Hui , Ren Jianwei , Hung Sung‐Fu , Li Linlin , Peng Shengjie 
Published: June 2023

AbstractThe direct correlation between active sites and catalytic activity in multiple‐component metal‐organic frameworks (MOFs) is key to understanding their mechanism of oxygen evolution reaction (OER) but remains vague. Herein, supported multiple‐site MOFs are adopted as model catalysts to quantitatively study the composition‐dependent OER performance. Ni MOFs on Fe metal substrate possess the highest intrinsic OER activity with the Ni/Fe ratio of 1:2 in the presence of metal leaching of the substrate during synthesis. Further introducing a proper amount of Cu further boosts the OER performance of Cu‐doped NiFe MOFs with an impressively low overpotential of 200 mV at 10 mA cm−2. Spectroscopic analysis with theoretical study indicates that the copper doping within the NiFe MOFs induces electron redistribution for high valence Fe sites with an optimized balance of OH/OOH adsorption and decreased energy barrier for improved OER. This work sheds light on the active site tailoring of MOFs which highly correlates with the OER activity.
What kinds of subsidies affect technical efficiency? The case of Italian dairy farms
Authors: Agostino Mariarosaria , Comert Ercan Enzo , Demaria Federica , Ruberto Sabrina 
Published: June 2023

AbstractThe relationship between subsidies and the technical efficiency of farms has important policy implications. The impact on efficiency can depend on the type of grant. Here, three macrocategories of subsidy are distinguished. With reference to a large sample of Italian dairy farms, the macrocategory of rural development payments is further broken down according to the main types of subsidy received. A stochastic frontier analysis based on the Farm Accountancy Data Network reveals a heterogeneous influence of these categories. Subsidies coupled with production are associated with greater efficiency. Decoupled grants have a negative influence on efficiency when pursuing agri‐environmental policy objectives, and no impact on efficiency when supporting the income of farms or promoting the transfer of knowledge and competitiveness. [EconLit Citations: C13, Q12].
Development of a concentration‐controlled sequential nanoprecipitation for making lipid nanoparticles with high drug loading
Authors: Xu Letao , Wang Xing , Yang Guangze , Zhao Zihan , Weng Yilun , Li Yang , Liu Yun , Zhao Chun‐Xia 
Published: June 2023

AbstractLipid‐based nanostructures have garnered considerable interests over the last two decades, and have achieved tremendous clinical success including the first clinical approval of a liposome (Doxil) for cancer therapy in 1995 and the recent COVID‐19 mRNA lipid nanoparticle vaccines. Compared to liposomes which have a lipid bilayer surrounding an aqueous core, lipid nanoparticles with a particle structure have several attractive advantages for encapsulating poorly water‐soluble drugs such as better stability due to the particle structure, high drug encapsulation efficiency because of a pre‐ or co‐drug‐loading strategy. While many studies have reported the synthesis of lipid nanoparticles for hydrophobic drug encapsulation, the precise control of drug loading and encapsulation efficiency remains a significant challenge. This work reports a new concentration‐controlled nanoprecipitation platform technology for fabricating lipid nanoparticles with tunable drug loading up to 70 wt%. This method is applicable for encapsulating a wide range of drugs from very hydrophobic to slightly hydrophilic. Using this facile method, nanoparticles with tunable drug loading exhibited excellent properties such as small particle size, narrow size distribution, good particle stability, showing great promise for future drug delivery applications.
Adaptive katalytische Systeme für die chemische Energiekonversion
Authors: Bordet Alexis , Leitner Walter 
Published: June 2023

AbstractDie stark wachsende Bedeutung von grünem Wasserstoff und erneuerbaren Kohlenstoffressourcen als Rohstoffbasis für nachhaltige Wertschöpfungsketten eröffnet Raum für bahnbrechende Innovationen bei chemischen Produktionsprozessen. Die Fluktuation und Variabilität, die mit der Versorgung mit nicht‐fossilen Energieträgern und Rohstoffen einhergehen, stellen Katalysatoren vor viele Herausforderungen, um die daraus resultierende Dynamik zu bewältigen. Allerdings ergeben sich auch viele neue Möglichkeiten, wenn das Katalysatordesign auf eine Leistung abzielt, die “adaptiv” und nicht “aufgabenspezifisch” ist. In diesem Beitrag schlagen wir vor, Adaptivität in der Katalyse auf der Grundlage von drei wesentlichen Eigenschaften zu definieren, nämlich Reversibilität, Rapidität und Robustheit (R3‐Regel). Zur Begründung des wissenschaftlichen Konzepts und zur Darstellung seines Potenzials für die chemische Energiekonversion werden vielversprechende Designstrategien und ausgewählte Beispiele beschrieben.
Cognitive, behavioral, and brain functional connectivity correlates of fatigue in amyotrophic lateral sclerosis
Authors: Trojsi Francesca , Di Nardo Federica , D'Alvano Giulia , Passaniti Carla , Sharbafshaaer Minoo , Canale Fabrizio , Russo Antonio , Silvestro Marcello , Lavorgna Luigi , Cirillo Mario , Esposito Fabrizio , Tedeschi Gioacchino , Siciliano Mattia 
Published: June 2023

AbstractIntroductionFatigue is defined as a symptom of exhaustion unexplained by drug effects or psychiatric disorders and comprises two main components (i.e., central or “mental” and peripheral or “physical” components), both influencing global disability in amyotrophic lateral sclerosis (ALS). We aim at investigating the clinical correlations between “physical” and “mental” components of fatigue, measured by the Multidimensional Fatigue Inventory scale, and motor and cognitive/behavioral disability in a large sample of patients with ALS. We also investigated the correlations between these measures of fatigue and resting‐state functional connectivity of brain functional magnetic resonance imaging (RS‐fMRI) large‐scale networks in a subset of patients.MethodsOne hundred and thirty ALS patients were assessed for motor disability, cognitive and behavioral dysfunctions, fatigue, anxiety, apathy, and daytime sleepiness. Moreover, the collected clinical parameters were correlated with RS‐fMRI functional connectivity changes in the large‐scale brain networks of 30 ALS patients who underwent MRI.ResultsMultivariate correlation analysis revealed that “physical” fatigue was related to anxiety and respiratory dysfunction, while “mental” fatigue was related to memory impairment and apathy. Moreover, the mental fatigue score was directly related to functional connectivity in the right and left insula (within the salience network), and inversely related to functional connectivity in the left middle temporal gyrus (within the default mode network).ConclusionsAlthough the “physical” component of fatigue may be influenced by the disease itself, in ALS the “mental” component of fatigue correlates with cognitive and behavioral impairment, as well as with alterations of functional connectivity in extra‐motor networks.
Right heart catheterization predictors of symptomatic improvement in patients undergoing transcatheter tricuspid valve edge‐to‐edge repair
Authors: Rezkalla Joshua , Reddy Yogesh , Nishimura Rick A. , Padang Ratnasari , Pislaru Sorin V. , Rihal Charanjit S. , Eleid Mackram F. 
Published: June 2023

AbstractBackgroundTranscatheter tricuspid valve edge‐to‐edge repair (TTEER) is associated with improvement in outcomes for symptomatic patients with severe tricuspid regurgitation (TR). However, reliable predictors for clinical success are not yet fully defined. This study aims to describe right heart catheterization (RHC) findings in patients referred for TTEER and identify hemodynamic characteristics of patients who experience immediate symptomatic improvement following successful TR intervention.MethodsPatients who underwent TTEER and had a separate RHC within the preceding 6 months were included. Hemodynamic tracings from the RHC and TTEER procedures were reviewed and recorded. Clinical success was defined as a successful device implant with at least 1‐grade of TR reduction and improvement in NYHA class by 1 or more grades on 30‐day echocardiogram and clinical follow‐up.ResultsThirteen patients underwent an RHC within 6 months of TTEER procedure (median age 76 years [IQR: 73–80]). All patients were on a stable dose of loop diuretics. Baseline right atrial pressure was severely elevated (mean 19 mmHg [IQR: 9–24 mmHg]) with prominent CV waves. Median pulmonary capillary wedge pressure (PCWP) was 20 mmHg (IQR: 14–22) and 70% of patients had a mean PCWP > 15 mmHg at rest. Median PCWP CV‐wave was 34 mmHg (IQR: 23–42). Higher PCWP CV‐wave height (40 mmHg [IQR 33–43] versus 18 mmHg [IQR 17–31]) was associated with lower likelihood of clinical success (OR 0.83, 95% CI: 0.35–0.97,p = 0.04).ConclusionsInclusion of invasive hemodynamics as part of pre‐TTEER evaluation may allow for improved TR phenotyping and patient selection. Patients with a large left atrial CV wave on resting RHC were less likely to experience immediate symptomatic improvement despite procedural success with TTEER.
Covalent Modification of Nanoparticle‐Imprinted Matrices for Selective Nanoparticle Recognition
Authors: Samuel Sweety Ann , Wittstock Gunther 
Published: June 2023

AbstractNanoparticle‐imprinted matrices (NAIMs) were prepared using ammonium‐terminated SiO2 nanoparticles (NPs) as templates initially attached to activated glassy carbon. After electrodeposition of a matrix of polyplumbagin and polyphenol, the selectivity of the polymer matrix was tuned towards the ligand shell of the Au analyte NPs by conjugate addition of substituted thiols to the plumbagin moiety within the matrix. The reactions were followed by cyclic voltammetry (CV) and the presence of thiols and amino groups in the film was verified by X‐ray photoelectron spectroscopy (XPS). After dissolution of the template NPs, the matrix had complementary cavities for the uptake of Au NPs. The amount of Au NP inside the cavities was quantified by the charge transferred during electrodissolution of the Au NPs in 3 M KCl in linear sweep voltammetry, which depended on the covalent modification of the polyplumbagin matrix, the pH during uptake and the size of the Au analyte NPs. The NAIM system modified with 1,2‐ethanedithiol showed the best uptake with 9.6×107 NPs cm−2 at pH 10, which is five times higher than the uptake of the same matrix at pH 5. In contrast, the cysteamine‐modified NAIM exhibited the highest uptake at pH 5.
Probing Achiral Benzene‐1,3,5‐tricarboxamide Monomers as Inducers of Homochirality in Supramolecular Helical Catalysts**
Authors: Kong Huanjun , Li Yan , Hammoud Ahmad , Dubreucq Ludovic , Troufflard Claire , Maruchenko Régina , Bouteiller Laurent , Raynal Matthieu 
Published: June 2023

AbstractAdding a complementary achiral monomer to polymers embedding a mixture of enantiopure monomers (the “sergeants”) and achiral monomers (the “soldiers”) is expected to decrease the optical purity of the polymer main chain. This study reports the influence of such achiral benzene‐1,3,5‐tricarboxamide (BTA) additives on the properties of “sergeants‐and‐soldiers” mixtures composed of an achiral BTA ligand coordinated to copper and of an enantiopure BTA monomer. Whilst N,N’,N’’‐tris(octyl)benzene‐1,3,5‐tricarboxamide (BTA C8) shows no significant improvement in term of enantioselectivity in the catalytic reaction of reference, achiral BTA monomers derived from α,α’‐disubstituted amino esters all lead to an increase in the selectivity at low “sergeant” ratio. This different behaviour was probed by characterizing the coassemblies embedding BTA C8, i. e. the worst‐performing achiral additive, and the BTA derived from the ester of 1‐aminocyclohexane carboxylic acid (BTA Achc), the best‐performing one. Both additives were found to efficiently intercalate with the ligand and the “sergeant” leading to the formation of single helices. However, only the terpolymer embedding BTA Achc appears to be homochiral, accounting for the good enantioselectivity even at very low “sergeant” ratio (0.25 %).
Synthesis of TMP esters as a biolubricant from canola oil via a two‐step transesterification–transesterification process
Authors: Kamyab Behzad , Beims Ramon Filipe , Chio Chonlong , Qin Wensheng , Chambers Darren W. , Xu Chunbao Charles 
Published: June 2023

AbstractTrimethylolpropane esters were synthesized from canola oil by a two‐step transesterification–transesterification process. In the first step, canola oil is reacted with ethanol to produce canola oil ethyl ester, while in the second step, canola oil trimethylolpropane ester was obtained by reacting the canola oil ethyl ester and trimethylolpropane using K2CO3 as a catalyst. In the first step, under the optimal reaction conditions (70°C, 2 h, ethanol‐to‐canola oil molar ratio of 10:1, and 0.25 wt.% catalyst loading), canola oil ethyl ester was successfully synthesized with a yield of 95.7 wt.%. In the second step, the final product with the maximum total concentration of canola oil trimethylolpropane ester (82%) and the maximum conversion of canola oil ethyl ester (85%) was obtained at 130°C for 3 h with a canola oil ethyl ester to trimethylolpropane molar ratio of 3.1:1, and 1 wt.% loading of K2CO3 catalyst. The produced polyol esters can be a promising biolubricant with excellent lubricant characteristics, quenching performance, biodegradability, and rheological/tribological properties.
Calcium Carbide: From Elemental Carbon to Isotope‐Economic Synthesis of 13C2‐Labeled Heterocycles†
Authors: Ledovskaya Maria S. , Voronin Vladimir V. , Valov Nikita R. , Samoylenko Dmitriy E. 
Published: June 2023

Comprehensive Summary13C‐Carbon is the most available source of carbon‐13. It is a relatively inexpensive solid material, which can be easily converted to calcium carbide‐13C2. In current work, Ca13C2 was used for in situ generation of 13C2‐acetylene in 1,3‐dipolar cycloaddition and [4+2] cycloaddition reaction. For the first time, 1H‐1,2,3‐triazoles‐4,5‐13C2 and isoxazoles‐4,5‐13C2 were synthesized using calcium carbide‐13C2. A Diels‐Alder type cycloaddition of 3,6‐di(pyridin‐2‐yl)‐1,2,4,5‐tetrazine and Ca13C2 was investigated, and the best way for the synthesis of 3,6‐di(pyridin‐2‐yl)pyridazine‐4,5‐13C2 was proposed for the first time. Here we perform a detailled description of NMR spectra of 13C2‐labeled triazoles, isoxazoles and 3,6‐di(pyridin‐2‐yl)pyridazine.
Enhancing privacy‐preserving mechanisms in Cloud storage: A novel conceptual framework
Authors: Mishra Alok , Jabar Thr Satar , Alzoubi Yehia Ibrahim , Mishra Kamta Nath 
Published: June 2023

SummaryData privacy is critical for users who want to use Cloud storage services. There is a significant focus on Cloud service providers to address this need. However, in the evolving dynamic cyber‐space, privacy infractions are rising and pose threats to Cloud storage infrastructures. Several studies developed various models and techniques to ensure the privacy of Cloud storage contents. However, these models came with several shortages in the privacy‐preserving attributes they cover. Thus, this article identified a comprehensive set of Cloud data storage privacy‐preserving attributes to propose a flexible and efficient framework to handle the privacy problem. This framework uses a multi‐layer encryption storage structure and a one‐time password authentication technique. The findings of this article intend to help future communities to enhance existing techniques or develop new research‐based practical alternatives. Since Cloud computing is a rapidly growing technology, new privacy vulnerabilities emerge daily. Future research might confirm the findings of this article and test the suggested framework in different contexts.
Design, Synthesis and Evaluation of Fluorescent Properties of Benzothiazole Derivatives
Authors: Sun Yi‐Tao , Zhang Chun , Gao Li‐Xin , Liu Min‐Min , Yang Yuting , Shao Andong , Zhou Yu‐Bo , Zhu Yun‐Long , Li Jia , Wang Wen‐Long 
Published: June 2023

AbstractFluorescence imaging is conducive to establish a bridge between molecular biology and clinical medicine, and provides new tools for disease process research, early diagnosis, and efficacy evaluation, because of the advantages of rapid imaging and nondestructive detection. Herein, a series of fluorescent molecules with thiadiazole, or thiazole, or benzothiazole cores were designed and synthesized to develop more excellent fluorescent molecules in bio‐imaging. According to theoretical and experimental methods, we found that benzothiazole derivative 14 B with conjugate expansion by (4‐aminophenyl) ethynyl group was the most excellent fluorescent molecule among all the investigated compounds and exhibited low cytotoxicity and strong blue and green fluorescence by confocal cell imaging.
Identification of bird cherry‐oat aphid and greenbug resistance sources from Aegilops tauschii for wheat improvement
Authors: Xu Xiangyang , Li Genqiao , Lhamo Dhondup , Carver Brett F. , Wulff Brande B. H. , Gu Yongqiang , Xu Steven S. , Armstrong Scott 
Published: June 2023

AbstractBird cherry‐oat aphid (BCOA) and greenbug pose a persistent threat to wheat production in many wheat‐growing regions. Currently, greenbug resistance genes are limited for wheat improvement, and BCOA resistance sources are even more scarce. Thus, it is urgent to identify BCOA and greenbug resistance sources in wheat gene pools. An Aegilops tauschii (Ae. tauschii) panel of 260 accessions, which accounted for 48% of the total Ae. tauschii accessions available in global germplasm banks, was evaluated for BCOA resistance, and a set of BCOA‐resistant lines were identified. The same panel was evaluated for response to greenbug biotypes C, E, F, G, I, and TX1. A total of 102 lines exhibited 14 unique resistance profiles or phenotypes featuring resistance to at least one biotype. The frequency of resistant lines varied among lineages or subspecies, from 62% in Lineage 1 (subspecies tauschii) to 18% in Lineage 2 (subspecies stangulata), indicating conservation of genetic variance for greenbug resistance was nonrandom. Ae. tauschii accessions resistant to both BCOA and greenbug were identified for enhancing aphid resistance.
The interaction between Epstein–Barr virus and multiple sclerosis genetic risk loci: insights into disease pathogenesis and therapeutic opportunities
Authors: Afrasiabi Ali , Ahlenstiel Chantelle , Swaminathan Sanjay , Parnell Grant P 
Published: June 2023

AbstractMultiple sclerosis (MS) is a chronic neurodegenerative autoimmune disease, characterised by the demyelination of neurons in the central nervous system. Whilst it is unclear what precisely leads to MS, it is believed that genetic predisposition combined with environmental factors plays a pivotal role. It is estimated that close to half the disease risk is determined by genetic factors. However, the risk of developing MS cannot be attributed to genetic factors alone, and environmental factors are likely to play a significant role by themselves or in concert with host genetics. Epstein–Barr virus (EBV) infection is the strongest known environmental risk factor for MS. There has been increasing evidence that leaves little doubt that EBV is necessary, but not sufficient, for developing MS. One plausible explanation is EBV may alter the host immune response in the presence of MS risk alleles and this contributes to the pathogenesis of MS. In this review, we discuss recent findings regarding how EBV infection may contribute to MS pathogenesis via interactions with genetic risk loci and discuss possible therapeutic interventions.
Good neighbors? Does aggregation of nests in an Arctic‐breeding shorebird influence daily survival rates?
Authors: Freeman Scott L. , Luff Katelyn M. , Gurney Kirsty E. B. 
Published: June 2023

AbstractOur current understanding of the factors that influence where birds nest is incomplete, yet such information is important for accurate demographic assessments. To address questions related to spatial distributions of shorebird nests and to evaluate factors that may affect nest distribution in these species, during 2017 and 2019, we studied a small population of semipalmated sandpiperCalidris pusillabreeding in the Central Canadian Arctic, near the Karrak Lake Research Station, in Nunavut. The spatial distribution of semipalmated sandpiper nests at this site suggested loose aggregation, with median nearest neighbor distances of 73.8 m and 92.0 m in 2017 and 2019, respectively, while no nests were detected on mainland areas in the vicinity. Evidence for the influence of nesting distribution on the daily survival rate of nests, however, was mixed. Neither nearest neighbor distance nor local nest density had a significant effect on daily nest survival in 2017, but in 2019, the best approximating model included an effect of local nest density, which indicated that nests in areas of high density had reduced survival rates. Contrary to other studies assessing settlement and nest site selection in semipalmated sandpipers, the spatial distribution of nests in this population demonstrates aggregation in an otherwise territorial species, but suggests that aggregated nesting can impose a cost on nest survival under certain conditions.