bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reducing Southern Ocean Shortwave Radiation Errors in the ERA5 Reanalysis with Machine Learning and 25 Years of Surface Observations
Authors: Mallet Marc D. , Alexander Simon P. , Protat Alain , Fiddes Sonya L. 
Published: February 2023

Abstract
Earth system models struggle to simulate clouds and their radiative effects over the Southern Ocean, partly due to a lack of measurements and targeted cloud microphysics knowledge. We have evaluated biases of downwelling shortwave radiation in the ERA5 climate reanalysis using 25 years (1995–2019) of summertime surface measurements, collected on the Research and Supply Vessel (RSV) Aurora Australis, the Research Vessel (R/V) Investigator, and at Macquarie Island. During October–March daylight hours, the ERA5 simulation of SWdown exhibited large errors (mean bias = 54 W m−2, mean absolute error = 82 W m−2, root-mean-square error = 132 W m−2, and R2 = 0.71). To determine whether we could improve these statistics, we bypassed ERA5’s radiative transfer model for SWdown with machine learning–based models using a number of ERA5’s gridscale meteorological variables as predictors. These models were trained and tested with the surface measurements of SWdown using a 10-fold shuffle split. An extreme gradient boosting (XGBoost) and a random forest–based model setup had the best performance relative to ERA5, both with a near complete reduction of the mean bias error, a decrease in the mean absolute error and root-mean-square error by 25% ± 3%, and an increase in the R2 value of 5% ± 1% over the 10 splits. Large improvements occurred at higher latitudes and cyclone cold sectors, where ERA5 performed most poorly. We further interpret our methods using Shapley additive explanations. Our results indicate that data-driven techniques could have an important role in simulating surface radiation fluxes and in improving reanalysis products.

Significance Statement
Simulating the amount of sunlight reaching Earth’s surface is difficult because it relies on a good understanding of how much clouds absorb and scatter sunlight. Relative to summertime surface observations, the ERA5 reanalysis still overestimates the amount of sunlight entering the Southern Ocean. We taught some models how to predict the amount of sunlight entering the Southern Ocean using 25 years of surface observations and a small set of meteorological variables from ERA5. By bypassing the ERA5’s internal simulation of the absorption and scattering of sunlight, we can drastically reduce biases in the predicted surface shortwave radiation. Large improvements in cold sectors of cyclones and closer to Antarctica were observed in regions where many numerical models struggle to simulate the amount of incoming sunlight correctly.
Aberrant expression of GOLM1 protects ALK+ anaplastic large cell lymphoma from apoptosis by enhancing BCL-XL stability
Authors: Zi Zhenguo , Du Shujuan , Zhang Liming , Wang Yuebo , Ding Ling , Zhang Chongqi , Wang Huanyu , Pawlicki Jan , Cai Yuan , Yao Yazhou , Zhou Feng , Tong Yin , Riley James L. , Cai Qiliang , Ma Xiaojing , Wei Fang 
Published: February 2023

Abstract
Golgi membrane protein 1 (GOLM1) is aberrantly expressed in many types of solid tumors and contributes to cancer development; however, its role in hematopoietic and lymphoid neoplasms remains unknown. Here, we report that GOLM1 was significantly upregulated in anaplastic large cell lymphoma (ALCL), particularly in anaplastic lymphoma kinase-positive (ALK+) ALCL. Mechanistically, the expression of GOLM1 was induced by nucleophosmin-ALK in both ALK-transformed T cells and ALCL cell lines through AKT/mTOR pathway. Knockdown of GOLM1 expression led to a reduction in the growth and viability of ALCL cells with increased spontaneous apoptosis, whereas ectopic expression of GOLM1 protected ALCL cells from apoptosis induced by staurosporine treatment. Moreover, GOLM1 directly interacted with B-cell lymphoma-extra large protein (a crucial anti-apoptosis regulator) and significantly prolonged its stability. Introduction of GOLM1 promoted ALK+ ALCL cells colony formation in vitro and tumor growth in a murine xenograft model. Taken together, our findings demonstrate, to our knowledge, for the first time that GOLM1 plays a critical role in suppressing apoptosis and promoting the progression of ALK+ ALCL and provide evidence that GOLM1 is a potential biomarker and therapeutic target in ALK-induced hematological malignancies.
The role of systemic ımmune ınflammatory ındex in showing active lesion ın patients with multiple sclerosis
Authors: Gokce Seyda Figul , Bolayır Asli , Cigdem Burhanettin , Yildiz Bulent 
Published: February 2023

Abstract
Background
Multiple sclerosis (MS) has two pathophysiological processes, one inflammatory and the other degenerative. We investigated the relationship between active lesions on magnetic resonance imaging showing the inflammatory phase in MS patients and serum parameters that can be used as inflammatory biomarkers. Thus, we aim to detect the inflammatory period in clinical and radiological follow-up and to reveal the period in which disease-modifying treatments are effective with serum parameters.

Methods
One hundred eighty-six MS patients presented to our hospital between January 2016 and November 2021 and 94 age- and sex-matched healthy volunteers were recruited for our study. While 99 patients had active lesions on magnetic resonance imaging, 87 patients did not have any active lesions. Neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), and monocyte/lymphocyte ratio (MLR) were determined. The SII (systemic immune inflammatory index) value was calculated according to the platelet X neutrophil/lymphocyte ratio formula.

Results
NLR, MLR, PLR and SII values were found to be statistically significantly higher in MS patients than in the control group. The NLR, MLR, PLR and SII were higher in the active group with gadolonium than in the group without active lesions. In addition, the cutoff values that we can use to determine the presence of active lesions were 1.53, 0.18, 117.15, and 434.45 for NLR, MLR PLR and SII, respectively.

Conclusions
We found that all parameters correlated with radiological activity. In addition, we showed that we can detect the inflammatory period with high sensitivity and specificity with the cutoff value used for SII and PLR. Among these easily accessible and inexpensive evaluations, we concluded that SII, including the values in the PLR formula, can come to the fore.
Association between sedentary behavior and chronic kidney disease in Korean adults
Authors: Jang Ye Seul , Park Yu Shin , Kim Hyunkyu , Hurh Kyungduk , Park Eun-Cheol , Jang Suk-Yong 
Published: February 2023

Abstract
Background

Chronic kidney disease (CKD) is a significant health care burden, with a worldwide prevalence of approximately 11%. The general population spends over 50% of the awake time sedentary activities. However, to the best of our knowledge, no study has evaluated the association between sedentary time and CKD, with a focus on both kidney damage and kidney function, in the South Korean population. Accordingly, the present study aimed to address this gap in the knowledge.

Method
We used data from the 8th Korea National Health and Nutrition Examination Survey. The analysis included 9,534 participants, especially excluded those who had been diagnosed with kidney disease or who were currently undergoing treatment. Sedentary behavior was self-reported by the participants. An estimated glomerular filtration rate (eGFR) and/or albuminuria were used as measures for detection of CKD according to the guidelines of the Kidney Disease Improving Global Outcomes. We analyzed the data using multiple logistic regression.

Results
Among the women, the risk of CKD was significantly greater among those who sat for ≥ 12 h/d relative to those who sat for < 6 h/d, after adjusting for physical activity and other covariates (odds ratio [OR]: 1.45, 95% confidence interval [CI]: 1.01–2.06). Similarly, among those who sat over 12 h/d, those who engaged in low levels of physical activity had a higher risk of CKD than those who engaged in high levels of activity (OR: 1.65, 95% CI: 1.04–2.61). No statistically significant results were found for men.

Conclusion
Excessive sedentary behavior was associated with an increased risk of CKD, especially albuminuria, regardless of the level of physical activity, only in women. These findings emphasize the importance of avoiding excessive sitting for a long time and increasing overall physical activity levels.
Factors impacting implementation of nutrition and physical activity policies in rural schools
Authors: Ausenhus Caryn , Gold Joshua M. , Perry Cynthia K. , Kozak Andrea T. , Wang Monica L. , Jang Sou Hyun , Leong Judy , Rodriguez Edgar , Duggan Catherine , Ko Linda K. 
Published: February 2023

Abstract
Background
Rural Latino children have higher rates of obesity compared to non-Latino Whites. Schools are in a unique position to address rural childhood obesity through policies. While evidence exists on factors that promote or impede school-based physical activity (PA) and nutrition policies, only a fraction has been in rural communities. This study seeks to understand 1) the knowledge and perceptions of school nutrition and PA policies and 2) barriers and facilitators to their implementation among rural school stakeholders from Washington State.

Methods
We conducted 20 semi-structured, in-depth interviews with school stakeholders (e.g., principals and school nutrition directors) from four K–12 school districts in the Lower Yakima Valley of Eastern Washington State. Thematic analysis was conducted using inductive, constant comparison approach to identify themes around knowledge and perceptions of policies and barriers and facilitators of policy implementation.

Results
Three main themes were identified: perceptions and knowledge of school PA and nutrition policies, barriers to policy implementation, and facilitators of policy implementation. The majority of stakeholders were supportive of school-based policies promoting PA and a healthy diet, even when lacking a specific understanding of these policies. Four subthemes were identified as barriers to policy implementation: viewing PA as a low priority, misuse of recess time, funding constraints, and lack of strong leadership. Facilitators of implementation included strong leadership at the district level, creating healthy norms through school-community linkages and pooling community resources to improve nutrition and PA among children.

Conclusions
Schools provide a unique setting to promote healthy diet and PA behaviors among children and their families. Study findings show that while knowledge of specific nutrition and PA policies may vary, support for such policies were high among rural stakeholders. Study findings can inform policy development and support strategies for policy implementation in rural settings. Future studies may want to examine whether implementation of strategies addressing the barriers and enhancing facilitators lead to success in rural school settings.
Simultaneous bilateral traumatic clavicle fractures: incidence, characteristics, and surgical outcomes
Authors: Feng Dongxu , Jiang Wuqiang , Kang Xiaomin , Jiang Yuxuan , Zhu Yangjun , Zhang Jun 
Published: February 2023

Abstract
Background
Although clavicle fractures are common injuries in adults, simultaneous bilateral clavicle fractures are rarely reported. The present report describes 13 patients with simultaneous bilateral traumatic clavicle fractures who were treated with surgical management and followed for more than 12 months postoperatively.

Methods
This retrospective chart review involved skeletally mature patients with traumatic clavicle injuries. Patients with bilateral clavicle fractures who were followed up for at least 12 months after surgery were included. Data regarding the patients’ demographics, injury characteristics, fracture classification, comorbidities, concomitant injuries, and treatment strategies were collected. Each displaced fracture was managed with open reduction and internal fixation. Postoperative follow-up included radiographs for assessment of bone union; calculation of the Constant–Murley score for shoulder function; administration of the Disability of the Arm, Shoulder, and Hand questionnaire for upper limb function; determination of the visual analogue scale score for pain; and assessment of complications.

Results
From October 2013 to November 2021, 15 patients (10 men, 5 women) were diagnosed with bilateral clavicle fractures among 1542 patients with clavicle injuries (overall incidence of 1.0%). Of these 15 patients, this study included 13 patients (8 men, 5 women; mean age, 38.3 ± 15.3 years) who were followed up for more than 12 months postoperatively. Among the 13 patients, 10 (77.0%) had associated concomitant injuries, and 25 sides were fixed with internal plate fixation. After a follow-up period of 29.9 ± 28.5 months, all fractures achieved bone healing. Eleven patients attained excellent shoulder function on both sides and returned to their pre-injury daily activities, and the remaining two patients had unilateral shoulder dysfunction. No complications occurred.

Conclusions
Bilateral clavicle fractures are extremely rare and associated with polytrauma. Open reduction and internal fixation is recommended for such patients, especially those with severe chest injuries, because osteosynthesis of the clavicle can improve respiratory function and reduce the duration of functional disability.
Prevalence of dental caries and relation with nutritional status among school-age children in resource limited setting of southern Ethiopia
Authors: Bassa Selamawit , Workie Shimelash Bitew , Kassa Yibeltal , Tegbaru Dawit Worku 
Published: February 2023

Abstract
Background
Globally, dental caries appears a major public health problem and a widespread non -communicable disease. It is more prevalent among children school-age children (6–12 years), However, there are few studies that correlate dental caries with nutritional status. Thus, this study aims to determine the relation of dental caries with nutritional status among school-age children at resource limited setting of southern Ethiopia.

Methodology
A community-based cross sectional study was employed on randomly selected 761 school-age children of Areka town. Data were collected by face-to-face interviewer-administered questionnaire and clinical assessment of dental caries. After that, the collected data were entered into Epi data 3.2.1 and exported to SPSS 20 for further analysis. On the other hand, bivariate and multiple logistic regression analyses were used to identify the association of dependent and independent variables. p Value < 0.05 was considered to declare a result as statistically significant.

Results
Prevalence of dental caries among school-age children was 15.6% (95% CI 13.0–18.5). In technical senses, 4.3% (95% CI 2.9–5.8%) of children were underweight and 14.2% (95% CI 11.7–16.6%) were overweight. However, it has been unfolded that the relationship between dental caries and nutritional status was not statistically significant with a p value (p = 0.32). Factors associated with dental caries were educational status of a mother AOR 3.14, (95% CI 1.03–9.56), not cleaning teeth AOR 7.70, (95% CI 4.00–14.85), sugared coffee drinking AOR 3.22, (95% CI 1.68–6.18.0), sweet food consumption AOR 4.19, (95% CI 1.76–9.96) and non-consuming milk AOR 5.66 ( 95% CI 1.49–21.49).

Conclusion and recommendation
Dental caries at south Ethiopia were low compared to WHO’s reports on oral health on school-age children. Tooth cleaning habit, parental education, sweet food consumption and milk consumption are associated factors. Therefore, behavioral intervention on dental hygiene and dietary practices are mandatory for school-age children.
What drives patients’ acceptance of Digital Therapeutics? Establishing a new framework to measure the interplay between rational and institutional factors
Authors: Carrera Alessandro , Zoccarato Francesca , Mazzeo Margherita , Lettieri Emanuele , Toletti Giovanni , Bertoli Simona , Castelnuovo Gianluca , Fresa Emanuele 
Published: February 2023

AbstractBackgroundThe rising incidence of chronic diseases among the population, further exacerbated by the phenomenon of aging, is a primary concern and a serious challenge for the healthcare systems worldwide. Among the wide realm of health digital technologies, the rise of Digital Therapeutics (DTx), which are medical devices able to deliver evidence-based treatments to manage and treat diseases, opens new opportunities. However, their diffusion and usage are still fragmented among countries. As the diffusion results from the adoption of technology from a social system and individual acceptance, this study aims to design and test a theoretical model that investigates the intention to use DTx, with a particular focus on the treatment of obesity, as a widespread and burdensome chronic condition.MethodsThis research is built on 336 answers coming from a survey to test the proposed model, which consists of a combination of organizational mechanisms, derived from Institutional Theory, and rational factors, derived from the Technology Acceptance Model (TAM). The survey has been delivered to patients and former patients of Istituto Auxologico Italiano, a hospital with several locations in northern Italy, recognized as a center of excellence for the treatment of obesity.ResultsThe analyses of the answers, performed through the Structural Equation Modelling (SEM) technique, confirmed the influence of the Perceived Usefulness on Intention To Use, and of the Perceived Ease Of Use on the Perceived Usefulness, confirming the validity of the assumptions derived from the TAM. On the other hand, institutional factors were introduced as antecedents of the Perceived Usefulness, and the Perceived Ease Of Use. Results show that the Regulative Pillar influences both the TAM constructs, the Normative Pillar (peer influence) has a positive effect only on the Perceived Usefulness, and finally, the Cultural Pillar impacts the Perceived Ease Of Use.ConclusionThis study allows filling the knowledge gap regarding the usage of the Institutional as a means to predict individuals’ intentions. Moreover, managerial contributions are available as the results have been operationalized into practical advice to managers and healthcare professionals to foster the adoption, and thus the diffusion, of Digital Therapeutics.
Symptom-based clusters in people with ME/CFS: an illustration of clinical variety in a cross-sectional cohort
Authors: Vaes Anouk W. , Van Herck Maarten , Deng Qichen , Delbressine Jeannet M. , Jason Leonard A. , Spruit Martijn A. 
Published: February 2023

Abstract
Background
Myalgic encephalomyelitis (ME)/chronic fatigue syndrome (CFS) is a complex, heterogenous disease. It has been suggested that subgroups of people with ME/CFS exist, displaying a specific cluster of symptoms. Investigating symptom-based clusters may provide a better understanding of ME/CFS. Therefore, this study aimed to identify clusters in people with ME/CFS based on the frequency and severity of symptoms.

Methods
Members of the Dutch ME/CFS Foundation completed an online version of the DePaul Symptom Questionnaire version 2. Self-organizing maps (SOM) were used to generate symptom-based clusters using severity and frequency scores of the 79 measured symptoms. An extra dataset (n = 252) was used to assess the reproducibility of the symptom-based clusters.

Results
Data of 337 participants were analyzed (82% female; median (IQR) age: 55 (44–63) years). 45 clusters were identified, of which 13 clusters included ≥ 10 patients. Fatigue and PEM were reported across all of the symptom-based clusters, but the clusters were defined by a distinct pattern of symptom severity and frequency, as well as differences in clinical characteristics. 11% of the patients could not be classified into one of the 13 largest clusters. Applying the trained SOM to validation sample, resulted in a similar symptom pattern compared the Dutch dataset.

Conclusion
This study demonstrated that in ME/CFS there are subgroups of patients displaying a similar pattern of symptoms. These symptom-based clusters were confirmed in an independent ME/CFS sample. Classification of ME/CFS patients according to severity and symptom patterns might be useful to develop tailored treatment options.
Discovery of potential FGFR3 inhibitors via QSAR, pharmacophore modeling, virtual screening and molecular docking studies against bladder cancer
Authors: Ganji Mahmoud , Bakhshi Shohreh , Shoari Alireza , Ahangari Cohan Reza 
Published: February 2023

Abstract
Background
Fibroblast growth factor receptor 3 is known as a favorable aim in vast range of cancers, particularly in bladder cancer treatment. Pharmacophore and QSAR modeling approaches are broadly utilized for developing novel compounds for the determination of inhibitory activity versus the biological target. In this study, these methods employed to identify FGFR3 potential inhibitors.

Methods
To find the potential compounds for bladder cancer targeting, ZINC and NCI databases were screened. Pharmacophore and QSAR modeling of FGFR3 inhibitors were utilized for dataset screening. Then, with regard to several factors such as Absorption, Distribution, Metabolism, Excretion and Toxicity (ADMET) properties and Lipinski’s Rule of Five, the recognized compounds were filtered. In further step, utilizing the flexible docking technique, the obtained compounds interactions with FGFR3 were analyzed.

Results
The best five compounds, namely ZINC09045651, ZINC08433190, ZINC00702764, ZINC00710252 and ZINC00668789 were selected for Molecular Dynamics (MD) studies. Off-targeting of screened compounds was also investigated through CDD search and molecular docking. MD outcomes confirmed docking investigations and revealed that five selected compounds could make steady interactions with the FGFR3 and might have effective inhibitory potencies on FGFR3.

Conclusion
These compounds can be considered as candidates for bladder cancer therapy with improved therapeutic properties and less adverse effects.
Identification of a variant in NLRP3 gene in a patient with Muckle-Wells syndrome: a case report and review of literature
Authors: Liu Jia , Zhang Ranran , Yi Zhi , Lin Yi , Chang Hong , Zhang Qiuye 
Published: February 2023

Abstract
Background
Cryopyrin-associated periodic syndrome (CAPS), a rare genetic autoimmune disease, is composed of familial cold autoinflammatory syndrome (FCAs), Muckle-Wells syndrome (MWS), and neonatal onset multisystem inflammatory disease (NOMID). MWS is caused by dominantly inherited or de novo gain-of-function mutations in the NOD-like receptor 3 (NLRP3) gene. At present, there is no report about the variation of R262W in China.

Case presentation
We reported a 3-year-old Chinese boy who had recurrent fever without obvious inducement, bilateral conjunctival congestion, and urticarial-like rash. Laboratory examination showed elevation in leukocyte count, neutrophil count, erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP) and serum amyloid protein (SAA) levels. Whole exome sequencing identified a missense variation c.784-786delinsTGG (p.R262W) in the coding region of the NLRP3 gene.

Conclusion
A classical variant of the NLRP3 gene in a patient with MWS was first reported in China.