bluuebunny/crossref_metadata_2025_split huggingface dataset:
Myosin light chain phosphorylation exhibits a gradient across the wall of cerebellar arteries under sustained ex vivo vascular tone
Authors: Sun Zhe , Li Zhaohui , Rodgers Mackenna , Zhang Liping , Hill Michael A. 
Published: January 2023

AbstractSmall blood vessel diseases are often associated with impaired regulation of vascular tone. The current understanding of resistance arteries often focuses on how a level of vascular tone is achieved in the acute phase, while less emphasis is placed on mechanisms that maintain vascular tone. In this study, cannulated rat superior cerebellar arteries (SCA) developed spontaneous myogenic tone and showed a marked and sustained constriction in the presence of diluted serum (10%), a stimulus relevant to cerebrovascular disease. Both phosphorylated myosin light chain (MLC-p) and smooth muscle alpha actin (SM-α-actin) aligned with phalloidin-stained actin filaments in the vessel wall, while exhibiting a ‘high to low’ gradient across the layers of vascular smooth muscle cells (VSMC), peaking in the outer layer. The MLC-p distribution profile shifted towards the adventitia in serum treated vessels, while removal of the serum reversed it. Furthermore, a positive correlation between the MLC-p signal and vessel wall tension was also evident. The gradients of phosphorylated MLC and SM-α-actin are consistent with a spatial regulation of the myosin-actin apparatus in the vessel wall during the maintenance of vascular tone. Further, the changing profiles of MLC-p and SM-α-actin are consistent with SCA vasoconstriction being accompanied by VSMC cytoskeletal reorganization.
Cardiovascular risk factors mediating the protective effect of education on cervical spondylosis risk
Authors: Sun Yang , Jin Manqiu , Yu Tiecheng , Zhang Jiting 
Published: January 2023

AbstractThe causal association between education and cervical spondylosis may be mediated partly through risk factors of cardiovascular disease. The identification of the protective effect of education and the evaluation of risk factors will help to optimize disease prevention at both clinical and public health levels. In this study, we applied several different Mendelian randomization (MR) methods to identify which cardiovascular factors underlie the clustering of cervical spondylosis with cardiovascular disease, and the degree to which these mediate an effect of education. Univariable MR analyses provided evidence supporting a protective effect of genetically predicted education on cervical spondylosis risk, and MVMR further identified the direct effect of education level. Our results also provided evidence supporting the detrimental effects of BMI and smoking on cervical spondylosis risk, with evidence that the effect of education is mediated through BMI and smoking. The proportions of the effect of education mediated through BMI and smoking were 12% and 3%, respectively. These findings highlight education, obesity, and smoking as common mechanisms underlying the clustering of cervical spondylosis with risk factors of cardiovascular disease, which might represent clinical and public health targets for reducing multi-morbidity and the burden of these common conditions.
Novel 3D Flipwell system that models gut mucosal microenvironment for studying interactions between gut microbiota, epithelia and immunity
Authors: Beamer Maria A. , Zamora Cassandra , Nestor-Kalinoski Andrea L. , Fernando Veani , Sharma Vandana , Furuta Saori 
Published: January 2023

AbstractGut mucosa consists of stratified layers of microbes, semi-permeable mucus, epithelium and stroma abundant in immune cells. Although tightly regulated, interactions between gut commensals and immune cells play indispensable roles in homeostasis and cancer pathogenesis in the body. Thus, there is a critical need to develop a robust model for the gut mucosal microenvironment. Here, we report our novel co-culture utilizing 3D Flipwell system for establishing the stratified layers of discrete mucosal components. This method allows for analyzing synchronous effects of test stimuli on gut bacteria, mucus, epithelium and immune cells, as well as their crosstalks. In the present report, we tested the immuno-stimulatory effects of sepiapterin (SEP, the precursor of the cofactor of nitric oxide synthase (NOS)—BH4) on the gut mucosal community. We previously reported that SEP effectively reprogrammed tumor-associated macrophages and inhibited breast tumor cell growth. In our co-cultures, SEP largely promoted mucus integrity, bacterial binding, and M1-like polarization of macrophages. Conversely, these phenomena were absent in control-treated cultures. Our results demonstrate that this novel co-culture may serve as a robust in vitro system to recapitulate the effects of pharmacological agents on the gut mucosal microenvironment, and could potentially be expanded to test the effects outside the gut.
A deeply conserved protease, acylamino acid-releasing enzyme (AARE), acts in ageing in Physcomitrella and Arabidopsis
Authors: Hoernstein Sebastian N. W. , Özdemir Buğra , van Gessel Nico , Miniera Alessandra A. , Rogalla von Bieberstein Bruno , Nilges Lars , Schweikert Farinha Joana , Komoll Ramona , Glauz Stella , Weckerle Tim , Scherzinger Friedrich , Rodriguez‐Franco Marta , Müller-Schüssele Stefanie J. , Reski Ralf 
Published: January 2023

AbstractReactive oxygen species (ROS) are constant by-products of aerobic life. In excess, ROS lead to cytotoxic protein aggregates, which are a hallmark of ageing in animals and linked to age-related pathologies in humans. Acylamino acid-releasing enzymes (AARE) are bifunctional serine proteases, acting on oxidized proteins. AARE are found in all domains of life, albeit under different names, such as acylpeptide hydrolase (APEH/ACPH), acylaminoacyl peptidase (AAP), or oxidized protein hydrolase (OPH). In humans, AARE malfunction is associated with age-related pathologies, while their function in plants is less clear. Here, we provide a detailed analysis of AARE genes in the plant lineage and an in-depth analysis of AARE localization and function in the moss Physcomitrella and the angiosperm Arabidopsis. AARE loss-of-function mutants have not been described for any organism so far. We generated and analysed such mutants and describe a connection between AARE function, aggregation of oxidized proteins and plant ageing, including accelerated developmental progression and reduced life span. Our findings complement similar findings in animals and humans, and suggest a unified concept of ageing may exist in different life forms.
Retracted: Research on intelligent elevation control method of shearer drum based on deep learning
Authors: Zhang Pu 
Published: January 2023

AbstractRetraction: [Pu Zhang, Research on intelligent elevation control method of shearer drum based on deep learning, IET Software 2023 (https://doi.org/10.1049/sfw2.12089)].The above article from IET Software, published online on 17 January 2023 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the Editor‐in‐Chief, Hana Chockler, the Institution of Engineering and Technology (the IET) and John Wiley and Sons Ltd. This article was published as part of a Guest Edited special issue. Following an investigation, the IET and the journal have determined that the article was not reviewed in line with the journal’s peer review standards and there is evidence that the peer review process of the special issue underwent systematic manipulation. Accordingly, we cannot vouch for the integrity or reliability of the content. As such we have taken the decision to retract the article. The authors have been informed of the decision to retract.
Speech-Language Pathology Services in Pediatric Cancer: Survey and Interview Data on Caregiver Experiences
Authors: Knollhoff Stephanie M. , Krueger Breanna I. , Imgrund Caitlin M. 
Published: January 2023

AbstractPediatric cancer and its treatment can cause disruption in typical child development, including the development of speech, language, and swallowing skills. Despite the potential for significant impact on communication and swallowing, speech-language pathologists are not routinely involved in the care teams of children diagnosed with cancer. The goal of this investigation was to enhance the understanding of the speech-language pathology services rendered and caregivers' perspectives on the current needs of children and adolescents who have undergone cancer treatment. Caregiver's perspectives offer unique insights and are beneficial when utilizing a person- and family-centered care framework. Eleven caregivers of children treated for cancer completed an online survey, and an additional three caregivers participated in a semistructured interview. Results provided insight into caregivers' perspectives regarding speech-language pathology-related needs and services. Survey results and thematic analysis of the semistructured interviews indicated the need for involvement of speech-language pathology services during and after cancer treatment. Cancer diagnoses and oncological treatment occur during key developmental periods, and may negatively impact children's speech, language, and swallowing abilities. Speech-language pathologists are uniquely positioned to provide support for children undergoing or following cancer treatment.
Sharing of misinformation is habitual, not just lazy or biased
Authors: Ceylan Gizem , Anderson Ian A. , Wood Wendy 
Published: January 2023

Why do people share misinformation on social media? In this research (
N
= 2,476), we show that the structure of online sharing built into social platforms is more important than individual deficits in critical reasoning and partisan bias—commonly cited drivers of misinformation. Due to the reward-based learning systems on social media, users form habits of sharing information that attracts others' attention. Once habits form, information sharing is automatically activated by cues on the platform without users considering response outcomes such as spreading misinformation. As a result of user habits, 30 to 40% of the false news shared in our research was due to the 15% most habitual news sharers. Suggesting that sharing of false news is part of a broader response pattern established by social media platforms, habitual users also shared information that challenged their own political beliefs. Finally, we show that sharing of false news is not an inevitable consequence of user habits: Social media sites could be restructured to build habits to share accurate information.
Final ion charge spectra upon cascade decay of inner-shell vacancies in atomic Au
Authors: Chaynikov A P , Kochur A G , Dudenko A I , Petrov I D , Yavna V A 
Published: January 2023

Abstract
Final ion charge spectra produced by the cascade de-excitations of 1s- to 5p
3/2-vacancies of the gold atom are calculated by direct construction and analysis of the cascade decay trees. The energies of multivacancy configurations arising in the course of the cascade development, and the partial widths of radiation and radiationless cascade transitions are calculated using the Pauli–Fock approximation. The energies of the cascade transitions are calculated as the differences of total Pauli–Fock energies of initial and final ionic configurations which allowed excluding energy-forbidden radiationless transitions in numerous multivacancy configurations. Partial widths of transitions are expressed in the form that allowed accounting for the effect of electron subshell populations on the transition widths. The partial widths of the transitions between the states of the overlapping initial and final state multiplets are corrected so as to exclude energy-forbidden transitions between the multiplet states. It is demonstrated that accurate accounting for possible forbiddance of transitions between cascade configurations and the exclusion of energy-forbidden term-to-term transitions between the multiplets’ states are crucial in deep-initial-vacancy cascade simulations.
Coulomb-blockade oscillation in CdS, ZnS and CdS/ZnS core-shell quantum dots
Authors: Kalita Pradip Kumar , Nanung Yowa , Das Hirendra 
Published: January 2023

Abstract
CdS, ZnS and core–shell CdS/ZnS quantum dots (QDs) with different ratio concentration of core to shell (1:1, 1:2, 1:3, 1:4, 1:5) were synthesized and their structural, optical and electrical properties were studied with respect to the increase shell thickness. XRD exhibits the wurtzite structure of CdS QDs along with the cubic trace of ZnS. HRTEM images exhibit spherical shaped particle morphology for both CdS and CdS/ZnS core–shell QDs. The optical properties show a defect control mechanism in carrier transport. Enhancing shell thickness introduces higher defect density, defect induced crystal strain and charge separation which leads to quantum mechanical tunneling in determination of conduction mechanism through QDs. The current-voltage (I-V) characteristics of the QD devices shows an oscillatory behavior which may be attributed to coulomb-blockade oscillations because of quantum structure of QDs. Room temperature quantum oscillation behavior has been studied systematically for the synthesized semiconductor core/shell QDs which is the major finding of the present work. Mullen’s two tunnel junction model has been used for the QD devices, which is in agreement with the observed coulomb oscillations for R1 ≪ R2 and C1 ≪ C2, originated from defect induced surface and interface of core/shell structure. The present experimental results may contribute towards study and development of futuristic quantum oscillatory nanoscale devices.
Combining cosmic shear data with correlated photo-z uncertainties: constraints from DESY1 and HSC-DR1
Authors: García-García Carlos , Alonso David , G. Ferreira Pedro , Hadzhiyska Boryana , Nicola Andrina , Sánchez Carles , Slosar Anže 
Published: January 2023

Abstract
An accurate calibration of the source redshift distribution p(z) is a key aspect in the analysis of cosmic shear data. This, one way or another, requires the use of spectroscopic or high-quality photometric samples. However, the difficulty to obtain colour-complete spectroscopic samples matching the depth of weak lensing catalogs means that the analyses of different cosmic shear datasets often use the same samples for redshift calibration. This introduces a source of statistical and systematic uncertainty that is highly correlated across different weak lensing datasets, and which must be accurately characterised and propagated in order to obtain robust cosmological constraints from their combination. In this paper we introduce a method to quantify and propagate the uncertainties on the source redshift distribution in two different surveys sharing the same calibrating sample. The method is based on an approximate analytical marginalisation of the p(z) statistical uncertainties and the correlated marginalisation of residual systematics. We apply this method to the combined analysis of cosmic shear data from the DESY1 data release and the HSC-DR1 data, using the COSMOS 30-band catalog as a common redshift calibration sample. We find that, although there is significant correlation in the uncertainties on the redshift distributions of both samples, this does not change the final constraints on cosmological parameters significantly. The same is true also for the impact of residual systematic uncertainties from the errors in the COSMOS 30-band photometric redshifts. Additionally, we show that these effects will still be negligible in Stage-IV datasets. Finally, the combination of DESY1 and HSC-DR1 allows us to constrain the “clumpiness” parameter to S
8 = 0.768+0.021
-0.017. This corresponds to a ∼√(2) improvement in uncertainties with respect to either DES or HSC alone.
Multiple-participant measurement-device-independent quantum secret sharing protocol based on entanglement swapping
Authors: Zhang Tao , Zhou Lan , Zhong Wei , Sheng Yu-Bo 
Published: January 2023

Abstract
Quantum secret sharing (QSS) is a multi-party quantum communication mode, which allows the dealer to split a key into several parts and send each part of a key to a participant. The participants can obtain the key only by cooperation. Entanglement swapping is a promising method to construct the entanglement channel. In the paper, we propose a multiple-participant measurement-device-independent QSS protocol based on entanglement swapping. All the measurement tasks are handed over to an untrusted measurement party, so that our protocol can resist all possible attacks from imperfect measurement devices. Our protocol requires the linear-optical Bell state analysis, which is easy to operate. Our protocol has application potential in the future quantum communication field.
Capturing and characterizing geometric complexities of metal additively manufactured parts using x-ray micro-computed tomography and multiscale curvature analyses
Authors: Bartkowiak Tomasz , Gapiński Bartosz , Wieczorowski Michał , Mietliński Patryk , Brown Christopher A 
Published: January 2023

Abstract
This study explores a quantitative analysis of multiscale geometric characterization of laser melted parts made of Ti-6Al-4V to establish functional relations between geometric characterisations and formation, or process, parameters. A focus is here is on multiscale curvature as a characterization of local shape which, unlike conventional texture characterizations, does not require a datum. Surfaces were measured using microCT scanner which, unlike conventional optical and stylus methods, can measure surfaces of re-entrant features. Laser power and scanning speed were considered as crucial AM process parameters in this study. It was found that curvature performed well in discriminating surfaces by both crucial process parameters and their combination for all analysed scales ranging from 0.005 to 1.000 mm. Strong functional correlations were established using linear regression (R2 = 0.83) for the largest considered scale, while no correlations were observed for fine scales associated with the powder particle sizes. It was noticed that large scale curvature increases with laser power and decreases with the scanning speed. That showed that multiscale curvature can be an easy-to-implement and valuable analysis for complex, freeform, AM metal surfaces.
A new technique for 3D printing dielectric structures using aerosol-jettable photopolymers
Authors: Areias Christopher , Piro Yuri , Ranasingha Oshadha , Akyurtlu Alkim 
Published: January 2023

Abstract
In this article, we report the development of a new method for the 3D printing of dielectrics. An aerosol-jet printer is used to deposit overlapping layers of photopolymer material under ultraviolet floodlight in the assembly of ramping microstructures in situ without the need for supporting structures. Printing is conducted using an in-house photodielectric ink, the development of which is presented with an emphasis on dielectric and mechanical bulk material characterization. Low dielectric loss at the X-band and structural strength are demonstrated, followed by print characterization wherein the driving mechanisms of the new method are explored, tied to print conditions, and related to specific material properties. Finally, a complex structure in the form of a 3D flower is printed to demonstrate the controlled and repeatable performance of the proposed technique.
Signal regulatory protein alpha is a conserved marker for mouse and rat spermatogonial stem cells
Authors: Miyazaki Takehiro , Kanatsu-Shinohara Mito , Ema Masatsugu , Shinohara Takashi 
Published: January 2023

AbstractCharacterization of spermatogonial stem cells (SSCs) has been hampered by their low frequency and lack of features that distinguish them from committed spermatogonia. Few conserved SSC markers have been discovered. To identify a new SSC marker, we evaluated SIRPA expression in mouse and rat SSCs. SIRPA was expressed in a small population of undifferentiated spermatogonia. SIRPA, and its ligand CD47 were expressed in cultured SSCs. Expression of both SIRPA and CD47 was upregulated by supplementation of GDNF and FGF2, which promoted SSC self-renewal. Sirpa depletion by short hairpin RNA impaired the proliferation of cultured SSCs, and these cells showed decreased MAP2K1 activation and PTPN11 phosphorylation. Immunoprecipitation experiments showed that SIRPA associates with PTPN11. Ptpn11 depletion impaired SSC activity in a manner similar to Sirpa depletion. SIRPA was expressed in undifferentiated spermatogonia in rat and monkey testes. Xenogenic transplantation experiments demonstrated that SIRPA is expressed in rat SSCs. These results suggest that SIRPA is a conserved SSC marker that promotes SSC self-renewal division by activating the MAP2K1 pathway via PTPN11.
An Autoethnographic Perspective of Life Story Work
Authors: Ricketts Deyanna 
Published: January 2023

Abstract
Life Story Work (LSW) is an intervention primarily used with care-experienced young people to help them produce a coherent, co-produced life narrative. The intervention has been in circulation since the 1960s, yet it has still been vastly under-researched. This article examines two models of LSW in circulation in the UK today and concludes that each model has its advantages and limitations. However, more research into the outcomes of LSW is needed. The article offers an autoethnographic case study of the author’s own experience of LSW and its potential outcomes to help inspire more researchers examine this vital intervention for a young person’s development.
Cataloging natural sialic acids and other nonulosonic acids (NulOs), and their representation using the Symbol Nomenclature for Glycans
Authors: Lewis Amanda L , Toukach Philip , Bolton Evan , Chen Xi , Frank Martin , Lütteke Thomas , Knirel Yuriy , Schoenhofen Ian , Varki Ajit , Vinogradov Evgeny , Woods Robert J , Zachara Natasha , Zhang Jian , Kamerling Johannis P , Neelamegham Sriram ,   the SNFG Discussion Group, Darvill Alan , Dell Anne , Henrissat Bernard , Bertozzi Carolyn , Lisacek Frederique , Hart Gerald , Narimatsu Hisashi , Freeze Hudson , Yamada Issaku , Paulson James , Marth Jamey , Vliegenthart J F G , Aoki-Kinoshita Kiyoko F , Etzler Marilynn , Aebi Markus , Campbell Matthew , Tiemeyer Michael , Kanehisa Minoru , Taniguchi Naoyuki , Edwards Nathan , Packer Nicolle , Stanley Pamela , Rudd Pauline , Seeberger Peter , Mazumder Raja , Ranzinger Rene , Cummings Richard , Sayle Roger , Schnaar Ronald , Perez Serge , Kornfeld Stuart , Kinoshita Taroh , York William 
Published: January 2023

AbstractNonulosonic acids or non-2-ulosonic acids (NulOs) are an ancient family of 2-ketoaldonic acids (α-ketoaldonic acids) with a 9-carbon backbone. In nature, these monosaccharides occur either in a 3-deoxy form (referred to as “sialic acids”) or in a 3,9-dideoxy “sialic-acid-like” form. The former sialic acids are most common in the deuterostome lineage, including vertebrates, and mimicked by some of their pathogens. The latter sialic-acid-like molecules are found in bacteria and archaea. NulOs are often prominently positioned at the outermost tips of cell surface glycans, and have many key roles in evolution, biology and disease. The diversity of stereochemistry and structural modifications among the NulOs contributes to more than 90 sialic acid forms and 50 sialic-acid-like variants described thus far in nature. This paper reports the curation of these diverse naturally occurring NulOs at the NCBI sialic acid page (https://www.ncbi.nlm.nih.gov/glycans/sialic.html) as part of the NCBI-Glycans initiative. This includes external links to relevant Carbohydrate Structure Databases. As the amino and hydroxyl groups of these monosaccharides are extensively derivatized by various substituents in nature, the Symbol Nomenclature For Glycans (SNFG) rules have been expanded to represent this natural diversity. These developments help illustrate the natural diversity of sialic acids and related NulOs, and enable their systematic representation in publications and online resources.