bluuebunny/crossref_metadata_2025_split huggingface dataset:
TRAINING THE NEXT GENERATION OF GERONTOLOGICAL LEADERSHIP: WHO AND HOW?
Authors: Charness Neil , Heyn Patricia , Appleby James 
Published: December 2022

Abstract
Knowing how to train the next generation of gerontological leaders involves understanding where we are now and where we want to be in the coming decades. We outline the results of a survey of the membership of Directors of Aging Centers. The Directors of Aging Centers interest group in GSA has representation from the USA, Canada, and Europe. A survey was sent to the membership in late December with reminders in January and had 31 respondents. We discuss the results of the survey, highlighting the demographics of the current leadership (Neil Charness), perceived need for training by current leaders (Peter Lichtenberg), and consensus content of leadership training programs (Patricia Heyn). Patricia D’Antonio provides a perspective on GSA’s approach to professional development programs and avenues for soliciting funding for leadership training. Our discussant (James Appleby, CEO of GSA) will reflect on the need for training in the context of building the next generation of gerontological leadership. We plan to devote significant symposium time to solicit audience input on next steps for supporting the effort to improve the quantity, quality, and diversity of the gerontological leadership workforce.
GSA ACTIVITIES TO SUPPORT CAREER DEVELOPMENT: RELEVANCE TO DIRECTORS OF AGING CENTERS
Authors: D'Antonio Patricia 
Published: December 2022

Abstract
GSA continues to support our members through career development activities. These activities are designed to empower members to develop the necessary skills to advance their careers as leaders in the field of aging. Through activities like the GSA NIA R13 Diversity, Mentoring, and Career Development Technical Assistance Workshop, we strive to support, promote, and advance the training of diverse students in aging. This presentation will discuss how the experiences with this R13 project and other career development efforts inform additional activities of the Society through a well-framed aging lens. We also discuss the process of soliciting funding to support leadership training and the role that GSA can play in the application process.
STUDYING BIOLOGICAL AGING AND GEROSCIENCE IN HUMANS
Authors: Newman Anne 
Published: December 2022

Abstract
For geroscience to impact human health, its scientific underpinnings observed in animal models must also be relevant to humans, and therapies grounded in geroscience principles must be translatable to humans. Given the heterogeneity of human aging, chronological age alone is not a sufficient indicator of susceptibility to specific diseases, disabilities, or death, nor does it provide insights into the likelihood of benefiting from specific geroscience-inspired approaches. Bringing these metrics to large epidemiological studies and clinical trials has provided a number of important insights. For example, indices developed from aggregates of biomarker, physiological and clinical data have been shown to perform well in terms of predicting healthy aging, specific aging-related traits and mortality. Functional or composite outcomes have been favored for capturing health span in translational trials.
ASSESSING PURPORTED AGING THERAPIES IN THE CLINIC
Authors: Newman John 
Published: December 2022

Abstract
Aging is a universal human experience that looms large in popular and commercial culture. It can be difficult for patients and providers alike to sort fact from unproven plausibility and from potentially harmful fiction. Geroscience is an emerging field, and while some interventions involve repurposed or over-the-counter drugs with early clinical data, it is important to note that none yet have a specific aging-related indication and none have a consensus recommendation for clinical use in an aging context. Even highly plausible links to mechanisms of aging do not ensure that an intervention will be effective or risk-free, and not all purported therapies align with preclinical science. Finally, some purported therapies fall into potentially problematic regulatory gaps. With all of these considerations in mind, attendees will gain insights into applying their existing skills to evaluate this field, and new tools for critically evaluating geroscience literature to assist in patient-centered decision making.
DEMENTIA LIFE EXPECTANCIES: NEW KNOWLEDGE AND CONSIDERATIONS FROM THE HEALTH AND RETIREMENT STUDY
Authors: Garcia Marc , Tarraf Wassim , Chiu Chi-Tsun , Saenz Joseph , Reyes Adriana 
Published: December 2022

Abstract
Alzheimer's disease and related dementias (ADRD) are a growing public health crisis. Estimates on the prevalence and incidence of ADRD across and within population-based studies have varied in part due to competing measures to assess dementia status. Disentangling these inconsistencies is crucial for understanding dementia disparities among racial/ethnic, and nativity groups among older adults. Based on the Health and Retirement Study we examined across (Whites, Blacks) and within-group differences (US- and non-US-born Latinos) in estimates of dementia life expectancy, using four competing algorithmic techniques (i.e., the Langa-Weir, Expert, Hurd, and Lasso) for the classification of dementia ascertainment. Estimates of dementia life expectancy across algorithms largely point to dementia disparities in the prevalence of the disease across racial/ethnic, and nativity groups, regardless of the algorithmic technique utilized. Elucidating algorithms that can be utilized with different racial/ethnic groups may reduce bias in dementia assessment in the future.
NEW BEREAVEMENT IS A RISK FACTOR FOR BINGE DRINKING, SMOKING, AND POOR MENTAL HEALTH (2019 GEORGIA BRFSS)
Authors: Miles Toni 
Published: December 2022

Abstract
This presentation advances studies of population health by estimating the association between new bereavement and binge drinking rates among adults aged 50 years and older. In other reports, bereavement is associated with significantly higher rates of binge drinking among older adults. In 2019, the state of Georgia used an optional module in the Behavioral Risk Factor Surveillance Survey (BRFSS) to measure the prevalence of new bereavement. This is the first effort to capture population-level data on bereavement in Georgia. 45% of adults (4 million persons) aged 18 and older were newly bereaved in the 24 months prior to survey. Highest bereavement rates: adults aged 55 to 64 years (51%), unemployed (49%), and Black respondents (60%). Binge drinking rate for bereaved was 31 % (versus 23.6% not bereaved). Combined bereavement and binge drinking increased risk for poor mental health (OR = 2.83) and smoking (OR = 4.54).
REGULATION OF NEURONAL MITOCHONDRIAL BIOENERGETICS BY LIPID METABOLITES UPREGULATED IN DEMENTIA
Authors: Heimler Stephanie , Amick K Allison , Bergstrom Jaclyn , Jain Mohit , Molina Anthony J 
Published: December 2022

Abstract
Mitochondrial dysfunction occurs early in Alzheimer’s disease (AD) progression and is evident in the Central Nervous System (CNS) and peripheral circulating cells. While there is evidence indicating that bioenergetic decline can drive the early pathogenesis of AD, little is known about the extracellular factors that alter neuronal bioenergetic capacity. We hypothesized that circulating metabolites contribute to neuronal bioenergetic decline associated with AD. Using a cohort comprised of participants with normal cognition, mild cognitive impairment, and dementia, we show that human serum harbors circulating, non-cellular factors capable of mediating neuronal bioenergetic differences according to the cognitive status of the serum donor. We developed a novel screening-based approach to identify candidate “mito-active” lipid metabolites in human serum that could mediate differences in bioenergetic capacity. Among these, Nervonic Acid and 15-epi-PGA1 were predicted to be mitochondrial inhibitors upregulated in participants with dementia. Neurons exposed to physiologically-relevant ranges of these molecules in-vitro exhibited a dose-dependent reduction in maximal mitochondrial respiration. We found that 500ug/mL of Nervonic Acid and 9ug/mL of 15-epi-PGA1 reduced maximal mitochondrial respiration by 62.3% and 63.3%, respectively, thereby validating our screening and prediction approach. Future experiments may be directed towards investigating if and how these and other mito-active metabolites of interest cross the blood-brain barrier to meaningfully affect AD. Furthermore, identified mito-active molecules can be investigated in other clinical cohorts to examine their role/s in multiple age-related or neurological conditions. This work expands our mechanistic understanding of how extrinsic factors associated with age and cognitive status contribute to neuronal bioenergetic decline.
LANGUAGE-BASED DISCRIMINATION RELATES TO MEMORY COMPLAINTS AMONG LATINX/HISPANIC OLDER ADULTS
Authors: Soto Elizabeth , Chapman Silvia , Turney Indira , Zahodne Laura , Cosentino Stephanie , Brickman Adam , Vonk Jet , Manly Jennifer 
Published: December 2022

Abstract
Memory Complaints (MCs) are a risk factor for dementia, but research in this area has largely been limited to non-Latinx White adults. Previous studies have shown that Latinx/Hispanic individuals are at higher risk for Alzheimer’s Disease and Related Disorders (ADRD). The mechanisms underlying this disparity in ADRD are multidimensional and can include negative social stressors such as discrimination. Language discrimination can be a source of stress in this population and might be an important contributor to MCs. We examined if MCs varies as a function of language-based discrimination in a total of 495 Latinx/Hispanic older adults without dementia from the community-based Washington Heights Inwood Columbia Aging Project. Language-based discrimination was measured with a dichotomous item that inquired if individuals had been discriminated against because they do not speak English well (yes or no). A linear regression was conducted to examine the cross-sectional association between language-based discrimination and MCs adjusted for age, education, sex/gender, socioeconomic status (income), and depressive symptoms. The experience of language discrimination was independently associated with MCs (B= 0.83, 95% CI=0.13, 1.54, SE= 0.36, p= .021). Results demonstrate a relationship between negative stressors and the expression of MCs. Future studies should comprehensively examine other discriminatory stressors which may also impact the expression of MCs and the risk for progression to ADRD. Identifying language-based and other discriminatory stressors that negatively affect Latinx/Hispanic communities will allow us to develop models that aim to assess and prevent discrimination, as a protective mechanism for the development of MCs and ADRDs.
RACIAL AND ETHNIC VARIATIONS IN DEMENTIA DIAGNOSIS, SURVIVAL, AND END-OF-LIFE CARE QUALITY
Authors: Jarrín Olga , Rahemi Zahra , Gusmano Michael 
Published: December 2022

Abstract
In the United States most adults have a preference to die at home and is an indicator of good end-of-life care. In the context of dementia, family members and caregivers are decision makers and part of good and equitable care involves understanding cultural variation in attitudes and social norms related to dementia, death and dying, and the meaning of a good death. This symposium explores racial and ethnic variation in lifetime dementia diagnosis and end-of-life care quality indicators. The first presentation examines racial, ethnic, and geographic variation in the rarely discussed lifetime prevalence of dementia and survival time from dementia diagnosis to death using national Medicare data. The second presentation describes the relationship between end-of-life care planning and satisfaction with end-of-life care using data from the Health and Retirement Study. The third presentation describes variation in place of death, a key indicator of end-of-life care quality, by dementia diagnosis and race/ethnicity using national Medicare data. The fourth presentation examines variation in hospice use, another indicator of end-of-life-care quality, and place of death by dementia diagnosis, race, and ethnicity using national Medicare data. The symposium concludes with a presentation examining the relationship between place of death and satisfaction with care received using data from the Health and Retirement Study. The Institute for Healthcare Improvement’s Triple Aim (improving the experience of care, improving the health of populations, and reducing per capita costs of health care) serves as a lens for discussing policy and practice implications of the major findings from each presentation.
LATINO FAMILY CAREGIVERS’ EXPERIENCES COVERING OUT-OF-POCKET COSTS WHEN CARING FOR SOMEONE LIVING WITH DEMENTIA
Authors: Mage Susanna , Benton Donna , Gonzalez Alexander , Zaragoza Gabriela , Wilber Kathleen , Tucker-Seeley Reginald , Meyer Kylie 
Published: December 2022

Abstract
Family caregivers to persons living with dementia spend an average of $11,293 annually out-of-pocket on caregiving costs. Costs include home modifications, medications, and other daily expenses. Financial strain from caregiving affects caregiver mental and physical health and is unequally distributed across race/ethnicity groups. While other caregivers spend approximately one-quarter of their income on caregiving, the cost for Latinos family caregivers comprises nearly half of annual income. To gain insight into this disparity, eleven 1-hour in-depth qualitative interviews were conducted with Latino caregivers of persons living with dementia living in California and Texas. Interview transcripts were thematically coded, guided by the Tucker-Seeley Material–Psychosocial–Behavioral Model of financial strain. We identified four themes: 1) caregivers were concerned with meeting the daily needs of care recipients and would incur additional costs, such as credit card interest, to address immediate needs; 2) high levels of psychological distress were expressed regarding caregivers paying for the care of loved ones and themselves in the future; 3) caregivers wanted to use community resources that help older adults and their families but described stressful barriers accessing support. Further, Latino culture affected spending. For example, caregivers incurred shared living costs given reluctance to place loved ones in a nursing facility, exemplifying the concept of familismo. By understanding the factors contributing to high caregiving costs for Latino caregivers and the challenges met when addressing these costs, we can build approaches at both the individual- and policy-levels and develop culturally relevant interventions to help Latino families to lower care costs.
HOW AGE-FRIENDLY UNIVERSITIES CAN COMBAT AGEISM
Authors: Graf Allyson , Han Heather , Phillips Will , Wiley Jessica 
Published: December 2022

Abstract
At a time of growing enrollment among adult learners, student bodies are increasingly age diverse. Identifying and reducing age-related bias on campus may be multipurpose in supporting those who experience ageism while promoting professional skills to combat ageism in students' future careers. The extant literature has primarily focused on ageism in the workplace and ageism experienced by faculty and staff in higher education while less has focused on ageism experienced by adult students and the possible disruption this creates to feeling included as part of the campus community. We present data from a mixed methods study of adult learners assessing the extent to which they experience and are impacted by age-related bias on campus. Data are used to justify faculty and student training to improve intergenerational contact in the classroom and beyond under the broader umbrella of DEI initiatives.
IMPROVING DEMENTIA CARE IN CO-CREATION BETWEEN SCIENCE, PRACTICE, AND EDUCATION
Authors: de Bruin Simone , de Bruin Simone 
Published: December 2022

Abstract
Long-term care is transitioning from a medical-somatic model of care to a psychosocial model of care. This transition requires new ways of working, and thus different competences of health and social care professionals. Innovative learning environments of multiple stakeholders in long-term care are increasingly being created in the Netherlands to foster co-creation between science, practice (including persons with dementia) and education of current and future health and social care professionals. In this symposium, we will share experiences from the Netherlands. The first presentation describes the challenges current and future health and social care professionals are facing with regard to innovation in dementia care. We will further explain how these experiences were used to set up a learning community ‘living well with dementia’. The second presentation is dedicated to a participatory action research to develop new collaboration practices to address the often under-addressed theme of meaning in life among community dwelling older adults. The third presentation will focus on a co-creation project dedicated to a care innovation for migrants with dementia, being a guideline for managing challenging behaviour at home. In the plenary discussion after the three presentations, participants are invited to share experiences from their own countries and discuss the lessons learned.
WORKING TOWARD A LEARNING COMMUNITY ENABLING LIVING WELL WITH DEMENTIA
Authors: de Bruin Simone , Bakker Franka 
Published: December 2022

Abstract
Health and social care professionals play an important role in enabling to live well with dementia. Supporting living well from a psychosocial approach to care requires new ways of working and different competences compared to a medical-somatic approach to care. Interviews and group meetings with future (i.e. students) and current health and social care professionals organized in 2021, however, revealed that training to develop such competences and adopt these new ways of working receive little attention in the curricula of existing training programs. They further experience that their organisations insufficiently facilitate them (e.g. in terms of time, creating a positive learning climate) to actually use these competences and innovate their ways of working. Therefore, there is a need for creating innovative learning environments in the form of learning communities. These collaborations of stakeholders from science, practice, and education aim to accelerate innovation in dementia care based on lifelong learning and development.
ASSOCIATIONS BETWEEN SLEEP AND REST: ACTIVITY CHARACTERISTICS AND METABOLOMIC PROFILES IN OLDER MEN
Authors: Xiao Qian , Sampson Joshua , Shadyab Aladdin , LaCroix Andrea , Yaffe Kristine , Stone Katie 
Published: December 2022

Abstract
The association of sleep and rest-activity rhythms (RAR) with metabolic health is not fully understood. Previous studies have identified multiple metabolite markers in amino acid and lipid pathways associated with various characteristics of sleep. However, most of the studies used self-reported sleep, and limited studies have examined 24-hour RAR profiles, a more complete picture of activity. We studied 950 older men and measured metabolomics from fasting blood samples. We identified numerous metabolomic markers that were cross-sectionally associated with actigraphy-based measures of sleep (total sleep time, sleep efficiency, sleep timing) and RAR (amplitude, acrophase, mesor and overall rhythmicity). The majority of the associated metabolites were amino acids and lipids from a wide range of pathways, including metabolism pathways of branched chain amino acid metabolism, fatty acids, and gamma-glutamyl amino acids. Our preliminary findings suggest that sleep and RAR are widely involved in human metabolism.
NEW SPINS ON CLASSIC IDEAS ABOUT CONTEXT IN ADULT EMOTIONAL DEVELOPMENT
Authors: Springstein Tabea , English Tammy 
Published: December 2022

Abstract
Individuals often experience improvements in emotional well-being into old age. Understanding mechanisms contributing to these emotional outcomes in daily contexts can inform ways to support healthy aging. Development is embedded within various contexts that shape individuals’ experiences. Novel perspectives are emerging on how to conceptualize context and the way it can contribute to emotional development during the aging process. This symposium illustrates four innovative ways to consider contextual contributions to emotional well-being across adulthood. The first talk will use experience sampling to illustrate age differences in how daily situations contribute to emotion regulation related processes, showing that older adults can more easily distinguish between emotions when in familiar situations. The second talk will take a fresh perspective on psychosocial contexts by distinguishing between types of social interactions in couples, highlighting the important role of affection for well-being in adulthood. The third talk will introduce the idea that the body itself provides context for emotional processes, showcasing that the way this context affects emotional experience changes as individuals age. The fourth talk will center on how renewing our classical developmental models of context in modern ways can help to overcome shortcomings of previous research and provide insight into how engagement with environmental features contributes to well-being across the lifespan. In sum, this symposium features innovative perspectives on how context can be leveraged to gain a deeper understanding of psychosocial development into old adulthood and illustrates specific ways individuals can navigate their social world to preserve or improve mental health across adulthood.
INFLUENCE OF EARTH, WIND, AND FIRE ON WELL-BEING: THE CLASSIC CONCENTRIC CIRCLES MODEL OF CONTEXT IS ALSO FROM THE 1970S
Authors: Ng Michelle , Garron Angelina , Gerstorf Denis , Ram Nilam 
Published: December 2022

Abstract
Classic bioecological models of human development (Bronfenbrenner, 1979) highlight the influence that five layers of context have on individuals’ function and growth. Modern versions specifically highlight five specific aspects of context (socio-economic, social, physical, care/service, and technology) that influence both how older adults negotiate their daily lives and how they age. Using a collection of empirical findings obtained from our analyses of longitudinal panel data from the German SOEP, experience sampling data from iSAHIB, and screenome data from the Stanford HSP, we illustrate how differences in individuals’ engagement with green spaces (earth), ambient air pollution (wind), and smartphones (fire) may contribute to differences in daily emotional well-being and developmental changes in life satisfaction. We then use these examples to elucidate shortcomings of the hierarchical models used to frame investigations of context and development for the past 40 years – and suggest the classic models be renewed rather than continually recycled.