bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of IKZF1 genetic mutations as new molecular subtypes in acute myeloid leukaemia
Authors: Wang Yang , Cheng Wenyan , Zhang Yvyin , Zhang Yuliang , Sun Tengfei , Zhu Yongmei , Yin Wei , Zhang Jianan , Li Jianfeng , Shen Yang 
Published: June 2023

AbstractBackgroundGenetic mutations of IKZF1 have been frequently delineated in B‐lineage acute leukaemia (B‐ALL) but rarely elucidated in acute myeloid leukaemia (AML). IKZF1 mutations confer a poor prognosis in AML, and hotspot mutations of IKZF1, N159Y and N159S tend to occur in B‐ALL and AML respectively. However, the pathogenesis of IKZF1 N159S in AML and IKZF1 lineage susceptibility are largely unknown.MethodsThe genetic and clinical characteristics of IKZF1‐mutated AML patients were evaluated. Multi‐omics analysis and functional assays were performed in vitro using IKZF1 mutations knock‐in AML cell lines.Results23 (4.84%) small sequence variants of IKZF1 were identified in 475 newly diagnosed AML (non‐M3) patients. Based on RNA sequencing, three classes of IKZF1‐related AML were defined, including 9 patients (39.13%) with IKZF1 N159S mutations, 10 (43.47%) with CEBPA mutations and 4 others (17.39%). IKZF1 N159S may define a unique subgroup with higher HOXA/B expression and native B‐cell immune fractions. Gene expression data of multiple knock‐in cell lines indicate that the lymphocyte differentiation‐related MME and CD44 kept high expression in IKZF1 N159Y but were downregulated in N159S. CUT&TAG sequencing showed that IKZF1 N159S reshaped the binding profiles of IKZF1. Integration analysis suggested that the pathogenesis of IKZF1 N159S may depend on the deregulation of several cofactors, such as oncogenic MYC and CPNE7 targets.ConclusionsCollectively, we dissected the molecular spectrum and clinical features of IKZF1‐related AML, which may promote an in‐depth understanding of the pathogenesis, lineage susceptibility and clinical research of AML.
Small bowel capsule endoscopy examination and open access database with artificial intelligence: The SEE‐artificial intelligence project
Authors: Yokote Akihito , Umeno Junji , Kawasaki Keisuke , Fujioka Shin , Fuyuno Yuta , Matsuno Yuichi , Yoshida Yuichiro , Imazu Noriyuki , Miyazono Satoshi , Moriyama Tomohiko , Kitazono Takanari , Torisu Takehiro 
Published: June 2023

AbstractObjectivesArtificial intelligence (AI) may be practical for image classification of small bowel capsule endoscopy (CE). However, creating a functional AI model is challenging. We attempted to create a dataset and an object detection CE AI model to explore modeling problems to assist in reading small bowel CE.MethodsWe extracted 18,481 images from 523 small bowel CE procedures performed at Kyushu University Hospital from September 2014 to June 2021. We annotated 12,320 images with 23,033 disease lesions, combined them with 6161 normal images as the dataset, and examined the characteristics. Based on the dataset, we created an object detection AI model using YOLO v5 and we tested validation.ResultsWe annotated the dataset with 12 types of annotations, and multiple annotation types were observed in the same image. We test validated our AI model with 1396 images, and sensitivity for all 12 types of annotations was about 91%, with 1375 true positives, 659 false positives, and 120 false negatives detected. The highest sensitivity for individual annotations was 97%, and the highest area under the receiver operating characteristic curve was 0.98, but the quality of detection varied depending on the specific annotation.ConclusionsObject detection AI model in small bowel CE using YOLO v5 may provide effective and easy‐to‐understand reading assistance. In this SEE‐AI project, we open our dataset, the weights of the AI model, and a demonstration to experience our AI. We look forward to further improving the AI model in the future.
Reliability analysis of bridges under different loads using polynomial chaos and subset simulation
Authors: Ni Pinghe , Li Jun , Hao Hong 
Published: June 2023

AbstractReliability analysis of bridges is essential for the design of civil engineering structures. The classical methods, such as Monte Carlo Simulation (MCS) and subset simulation techniques, may provide accurate results. However, since the finite element model of the large‐scale civil engineering structures usually consists of a large number of degrees of freedom, structural reliability analysis of such structures is time‐consuming and computational intensive, which may restrict the use of these methods. This paper proposes a novel method for the reliability analysis of bridge under different types of loads by combining Polynomial Chaos (PC) and subset simulation techniques. The surrogate model of the limit state function is approximated by using the PC expansion, in which the PC coefficients are obtained from the least‐squares method. The subset simulation with a PC‐based surrogate model is then used to estimate the rare failure probability. Reliability analyses of bridge structures under different loading types, that is, static load, dynamic moving load, and seismic load are performed. Studies by using the MCS method and the classical subset simulation are also conducted, and the results from the proposed approach are compared with those from MCS and subset simulation to demonstrate the accuracy and efficiency of the proposed method.
Where does it hurt? Small area estimates and inequality in the prevalence of chronic pain
Authors: Lynch Marty , Peat George , Jordan Kelvin , Yu Dahai , Wilkie Ross 
Published: June 2023

AbstractBackgroundChronic pain affects up to half of UK adults, impacting quality of life and demand on local health services. Whilst local health planning is currently based on subnational prevalence estimates, associations between pain and sociodemographic characteristics suggest that inequalities in the prevalence of chronic and high‐impact chronic pain between neighbourhoods within local authorities are likely. We aimed to derive lower super output area (LSOA) estimates of the prevalence of chronic and high‐impact chronic pain.MethodsPresence of self‐reported chronic and high‐impact chronic pain were measured in adults aged 35+ in North Staffordshire and modelled using multilevel regression as a function of demographic and geographic predictors. Multilevel model predictions were post‐stratified using the North Staffordshire age‐sex population structure and LSOA demographic characteristics to estimate the prevalence of chronic and high‐impact chronic pain in 298 LSOAs, corrected for ethnic diversity underrepresented in the data. Confidence intervals were generated for high‐impact chronic pain using bootstrapping.ResultsData were analysed from 4162 survey respondents (2358 women, 1804 men). The estimated prevalence of chronic and high‐impact chronic pain in North Staffordshire LSOAs ranged from 18.6% to 50.1% and 6.18 [1.71, 16.0]% to 33.09 [13.3, 44.7]%, respectively.ConclusionsPrevalence of chronic and high‐impact chronic pain in adults aged 35+ varies substantially between neighbourhoods within local authorities. Further insight into small‐area level variation will help target resources to improve the management and prevention of chronic and high‐impact chronic pain to reduce the impact on individuals, communities, workplaces, services and the economy.SignificancePost‐stratified multilevel model predictions can produce small‐area estimates of pain prevalence and impact. The evidence of substantial variation indicates a need to collect local‐level data on pain and its impact to understand health needs and to guide interventions.
Comprehensive evaluation of target spectra for selecting bidirectional ground motions in nonlinear response history analysis of frame buildings at far‐field sites
Authors: Reyes Juan C. , Acosta Juan E. , Kwong N. Simon 
Published: June 2023

AbstractAn ensemble of bidirectional ground motions (GMs) is required as input for nonlinear response history analysis (RHA) of complex 3D structures. In building codes, an ensemble of GMs is often developed from a given design spectrum, or target spectrum. In the research literature, several target spectra have been proposed for such intensity‐based assessments. The present study aims to comprehensively evaluate different options for developing target spectra to select bidirectional GMs as inputs to nonlinear RHAs of 3D structural systems. To achieve this goal, we conducted both intensity‐based and risk‐based assessments of 49 multistory buildings with varying dynamic characteristics, heights, and plan shapes. The results from performing 11,074 bidirectional nonlinear RHAs and deriving the seismic demand hazard suggest that the Conditional Mean Spectrum‐Uniform Hazard Spectrum (CMS‐UHS) Composite Spectrum appears to be the most promising alternative. With less computational effort than use of multiple CMS, the Composite Spectrum tends to accurately estimate story drift ratios (average overestimation of 4%) and floor accelerations (average overestimation of 3%). Moreover, the relative ranking between the various target spectra options remains largely independent of the building type, height, and plan shape. However, the precision in estimates of demand tends to decrease for buildings with increasing complexity (e.g., more realistic, or taller, or more asymmetrical in plan).
Pathways between childhood maltreatment and life satisfaction in adolescents with eating disorders: A network analysis
Authors: Monteleone Alessio Maria , Cascino Giammarco , Meule Adrian , Barone Eugenia , Voderholzer Ulrich , Kolar David R. 
Published: June 2023

AbstractObjectiveThis study explored the association between Childhood maltreatment (CM) experiences and life satisfaction in adolescents with eating disorders (EDs).MethodsAdolescent inpatients with EDs completed the Childhood Trauma Questionnaire, the Satisfaction With Life Scale, the Brief Symptom Inventory and the Eating Disorder Inventory–2 at admission (n = 361) and discharge (n = 354). A network analysis was conducted to identify the shortest pathways between different types of CM and life satisfaction at admission and discharge.ResultsGeneral psychopathology, life satisfaction, and ED symptoms improved from admission to discharge. At admission, emotional abuse and emotional neglect were included in the pathway between sexual/physical abuse and life satisfaction. Emotional neglect was directly connected with life satisfaction while emotional abuse was connected through feeling disliked by others, feelings of inferiority and worthlessness. At discharge, only the direct negative connection between emotional neglect and perception of excellent conditions in the life persisted.ConclusionsEmotional maltreatment experiences and general psychopathology, but not disordered eating symptoms, are involved in the association between sexual/physical CM and life satisfaction in adolescents with EDs. Emotional neglect may affect life satisfaction regardless of symptoms severity. These findings inform clinicians for assessment and treatment of maltreated adolescents with EDs.
Epinecidin‐1 (an active marine antimicrobial peptide): Effects on the survival of inoculated Escherichia Coli O157:H7 And Staphylococcus aureus bacteria, antioxidant, and sensory attributes in raw milk
Authors: Salimnejhad Ziba , Hassanzadazar Hassan , Aminzare Majid 
Published: June 2023

AbstractThis study aimed to evaluate the effects of Epinecidin‐1 (Epi‐1) on total viable count (TVC), total psychrotrophic count (TPC), sensory attributes, and the survival of Escherichia Coli O157:H7 and Staphylococcus aureus bacteria inoculated in pasteurized milk samples during cold storage (4°C). Four treatments of milk samples were prepared including milk samples containing three concentrations of Epi‐1 (0.0025, 0.005, and 0.01%) and control (without Epi‐1). The treated milk samples were evaluated in vitro (minimum inhibitory concentration, Minimum bactericidal concentration, disk diffusion test, DPPH, reducing power assays) and in vivo (TVC, TPC, sensory properties, and enumeration of inoculated E. coli and S. aureus) during 9 days at cold storage. The best antibacterial and antioxidant power of Epi‐1 was observed at a concentration of 0.01%. Based on the MICs and MBCs, the most susceptible and resistant bacteria to Epi‐1 were B. cereus and S. aureus strains, respectively. The DPPH scavenging potential of Epi‐1 was in the range of 77%–80%. Treated samples containing 0.01% Epi‐1 had the lowest TVC and TPC and reached 3.9 and 2.96 CFU log/mL at the end day of storage. A decrease of 6 and 1.4 logs CFU/g of E. coli O157:H7 and S. aureus was seen in all treatments containing Epi‐1, respectively, on the last day of storage period. There are no unpleasant sensory properties in treated samples with Epi‐1. Our results indicate that Epi‐1 has good potential as a bio‐preservative to prevent raw milk spoilage and reduction of milk‐borne pathogens.
Comparative impact of grade on mortality across salivary cancers: A novel, unifying staging system
Authors: Ho Allen S. , Luu Michael , Balzer Bonnie L. , Aro Katri , Jang Julie K. , Mita Alain C. , Scher Kevin S. , Mallen‐St. Clair Jon , Vasquez Missael , Bastien Amanda J. , Epstein Joel B. , Lin De‐Chen , Chen Michelle M. , Zumsteg Zachary S. 
Published: June 2023

AbstractBackgroundThe comparative impact of histologic variants and grade has not been well described.MethodsSalivary cancer histologies were profiled using hospital and population‐based cancer registries. Multivariable models were employed to assess relationships between histology, grade, and survival.ResultsOn univariate analysis, histologic variants exhibited a wide spectrum of mortality risk (5‐year overall survival (OS): 86% (acinic cell carcinoma), 78% (mucoepidermoid carcinoma), 72% (adenoid cystic carcinoma), 64% (carcinoma ex‐pleomorphic adenoma), 52% (adenocarcinoma NOS), and 47% (salivary duct carcinoma) (p < 0.001). However, on multivariable analysis these differences largely vanished. Worsening grade corresponded with deteriorating survival (5‐year OS: 89% [low‐grade], 81% [intermediate‐grade], 45% [high‐grade]; p < 0.001), which was upheld on multivariable analysis and propensity score matching. Recursive partitioning analysis generated TNM + G schema (c‐index 0.75) superior to the existing system (c‐index 0.73).ConclusionGrade represents a primary determinant of salivary cancer prognosis. Integrating grade into stage strengthens current staging systems.
Sovereign credit and geopolitical risks during and after the EMU crisis
Authors: Bratis Theodoros , Kouretas Georgios P. , Laopodis Nikiforos T. , Vlamis Prodromos 
Published: June 2023

AbstractThis paper focuses on the sovereign crisis of the Euro debt crisis era, and we address the existence of the relationship of CDS and bond markets sovereign credit risk pricing for selected core and periphery EMU countries, during and after the 2009 EMU crisis. We study this relationship in conjunction to geopolitical risk as a measure of macroeconomic uncertainty. We use daily observations for several bond maturities and CDS premium with reference to the core (France and Germany) versus periphery EMU countries (Portugal, Italy, Ireland Spain, and Greece) for the period 2009 to 2014. To measure global geopolitical risk, we employ the Caldara and Iacoviello (2022) global geopolitics index (GPR). Using alternative econometric approaches, we find adequate evidence of volatility spillovers between the geopolitical risk index and sovereign risk markets mainly during the crisis period (2009–2012) and weaker during the easing of the eurozone debt crisis period (2012–2014). Moreover, based on Granger causality the estimation of the short‐ term dynamics reveals a significant linkage during the post‐crisis period rather than during crisis. During the crisis period, we found significant dynamic responses between GPR and bond yields.
Impact of HIV infection on access to cancer care and survival among women with invasive cervical cancer in Côte d'Ivoire: A prospective cohort study
Authors: Boni Simon P. , Horo Apollinaire , Didi‐Kouko‐Coulibaly Judith , Tanon Aristophane , Tchounga Boris K. , Coffie Patrick A. , Comoe Jean‐Claude , Moh Raoul D. , Dabis François , Adoubi Innocent , Jaquet Antoine ,   The IeDEA West Africa Collaboration
Published: June 2023

AbstractObjectiveTo assess the impact of HIV on access to invasive cervical cancer (ICC) care and overall survival (OS) in a time of universal access to antiretroviral therapy (ART).MethodsA cohort of women prospectively diagnosed with ICC was consecutively recruited from 2018 to 2020 in public/private cancer centers in Côte d'Ivoire. Follow‐up data were collected through facility‐ and phone‐based approaches. Logistic and Cox regression models allowed analysis of factors associated with access to cancer care and OS, respectively.ResultsOverall, 294 women with ICC aged 50 years (interquartile range [IQR] 43–60) were enrolled, including 21.4% of women living with HIV (WLHIV), 87% being on ART. An advanced ICC clinical stage (III–IV) was less frequent in WLHIV (63.5% vs. 77.1% in HIV‐uninfected women; P = 0.029). Cancer care was initiated in 124 (42.2%) women (54.0% in WLHIV; 39.0% in HIV‐uninfected; P = 0.030). Factors independently associated with access to cancer care were International Federation of Gynecology and Obstetrics (FIGO) stage I–II (adjusted odds ratio [aOR] 3.58, 95% CI 2.01–6.38) and no treatment by traditional healers prior to ICC diagnosis (aOR 3.69, 95% CI 1.96–6.96). The 2‐year OS was 37.9% (95% CI 30.0–47.9). HIV status was not predictive of mortality (adjusted hazard ratio [aHR] 0.98, 95% CI 0.60–1.69). An advanced clinical stage was the only measured predictor of death (aHR 1.59, 95% CI 1.02–2.47).ConclusionIn a time of universal access to ART, HIV infection was not associated with OS among women with ICC in Côte d'Ivoire. Higher access to cancer care in WLHIV might be mediated by enhanced access to ICC screening services, supporting the need to expand these services to other types of healthcare facilities.
An integrated qualitative and quantitative study on sexual and reproductive health problems faced by women with disabilities in Chandigarh, India
Authors: Sharma Ruchi , Kumar Ajit , Suri Vanita , Kaur Sukhpal , Singh Amar Jeet 
Published: June 2023

AbstractObjectivesTo estimate the prevalence of sexual and reproductive health (SRH) problems among women with disabilities (WWD) in Chandigarh, India, and to ascertain the difficulties experienced by WWD in accessing hospital services.MethodsThis cross‐sectional study was conducted during 2014 to 2017 in Chandigarh, India. The study participants were women 15 years and older with at least 40% disability. A pretested questionnaire and in‐depth interview were used to determine sociodemographic profile, medical history, sexual and reproductive morbidity, treatment‐seeking behavior, and the type, extent, and course of the disability. Verbatim responses of the participants were noted. Data were manually coded and collated into possible themes.ResultsPostpolio residual paralysis (80; 30.7%) was the main reported disability, followed by severe sight impairment (52; 19.9%). A majority (170; 65%) of participants were unmarried. Of them, 66 (39%) were not willing to get married. The prevalence of SRH problems was high (151; 57.9%) among WWD, and only 82 (54%) took treatment. Dysmenorrhea (47; 31.1%), irregular periods (36; 23.8%), and vaginal discharge (17; 11.3%) were the main problems reported. The WWD in this study were likely to hide their SRH problems from others out of shame or fear.ConclusionAmong WWD, the prevalence of SRH problems is high and obtaining relief is difficult.
Research for accurate auxiliary diagnosis of lung cancer based on intracellular fluorescent fingerprint information
Authors: Tian Chongxuan , Zhu He , Meng Xiangwei , Ma Zhixiang , Yuan Shuanghu , Li Wei 
Published: June 2023

AbstractThe distinctions in pathological types and genetic subtypes of lung cancer have a direct impact on the choice of treatment choices and clinical prognosis in clinical practice. This study used pathological histological sections of surgically removed or biopsied tumor tissue from 36 patients. Based on a small sample size, millions of spectral data points were extracted to investigate the feasibility of employing intracellular fluorescent fingerprint information to diagnose the pathological types and mutational status of lung cancer. The intracellular fluorescent fingerprint information revealed the EGFR gene mutation characteristics in lung cancer, and the area under the curve (AUC) value for the optimal model was 0.98. For the classification of lung cancer pathological types, the macro average AUC value for the ensemble‐learning model was 0.97. Our research contributes new idea for pathological diagnosis of lung cancer and offers a quick, easy, and accurate auxiliary diagnostic approach.
Perspective in resource recovery from reverse osmosis brines: the case for sustainable seawater refineries for small islands
Authors: Acevedo Diego , Mijts Eric , John Nigel , El Bouzidi Mohamed , van der Bruggen Bart 
Published: June 2023

AbstractReverse osmosis has become the dominant technique for desalination while at the same time there is a steady increase in reliance on desalination systems for water production globally. Resource recovery and mitigation of adverse effects from brine discharge are important factors and are increasingly being considered by researchers and industrial actors. The island nation of Aruba, with over 100 years of commercial desalination history, is used as a case study to illustrate the possibilities of shifting from centralized seawater desalination plants to seawater refineries in which freshwater is considered only one of the possible products. We identify possible economic value from desalination plants of medium scale (as is the case in Aruba) from the production of magnesium, caustic soda, chlorine‐based products and rubidium and possible energy recovery possibilities through osmotic gradients and/or hydrogen storage while at the same time highlighting the insufficient potential for lithium harvesting from seawater desalination brines. We have found that the economic value from resources recovered from brine may be even larger than the value of the freshwater produced by these plants. Furthermore, reduction of salinity and quantity of brine can reduce the overall ecological impact from current brine effluents. © 2023 Society of Chemical Industry (SCI).