bluuebunny/crossref_metadata_2025_split huggingface dataset:
Soil Organic Carbon Stabilization Is Dominated by Non‐Sorptive Process Among the Subsoils From Different Parent Material
Authors: Yu Mengxiao , Wang Ying‐Ping , Jiang Jun , Cao Nannan , Chang Zhongbing , Zhang Shuo , Yan Junhua 
Published: March 2023

AbstractSoil parent material can strongly influence soil's physical and chemical properties, significantly affecting soil organic carbon (SOC) stabilization. However, the importance of different soil parent materials on the amount and composition of subsoil carbon in subtropical soils remains poorly qualified. Subsoil SOC (below A horizon) is chosen for this study because of its higher proportion of stable carbon than surface soils in A horizon. Here, we investigated the dependence of soil mineral‐associated organic carbon (MAOC) and its three mineral‐stabilized fractions on soil physical and chemical parameters (clay content, cation exchange capacity (CEC) and metal oxides) in the subsoil soil (B and C horizons) originating from three contrasting parent materials (sandshale, granite, limestone). The results showed that MAOC accounts for an average of 88% of total SOC, of which organo‐metal complexes (extracted with sodium pyrophosphate) are the dominant form at all three sites. MAOC and its three fractions were significantly correlated with soil clay, CEC, sodium pyrophosphate extractable Fe and oxalate extractable Fe concentrations (P < 0.05), which varied significantly with soil parent material. Since the sodium pyrophosphate plus oxalate‐ extracted mineral‐associated carbon accounted for more than 70% of MAOC, and the molar ratio between sodium pyrophosphate or oxalate‐ extracted mineral‐associated carbon and Fe (C:Fe) ranged from 2.7 to 17.1. The formation of Fe‐associated organic complex is dominated by co‐precipitation when C:Fe is >1. Therefore we conclude that non‐sorptive interactions with the mineral phase through co‐precipitation are the dominant mechanism for SOC stabilization in subtropical forest soils.
Hydrodynamic Feedbacks of Salt‐Marsh Loss in the Shallow Microtidal Back‐Barrier Lagoon of Venice (Italy)
Authors: Finotello Alvise , Tognin Davide , Carniello Luca , Ghinassi Massimiliano , Bertuzzo Enrico , D’Alpaos Andrea 
Published: March 2023

AbstractExtensive loss of salt marshes in back‐barrier tidal embayments is ongoing worldwide as a consequence of land‐use changes, wave‐driven lateral marsh erosion, and relative sea‐level rise compounded by mineral sediment starvation. However, how salt‐marsh loss affects the hydrodynamics of back‐barrier systems and feeds back into their morphodynamic evolution is still poorly understood. Here we use a depth‐averaged numerical hydrodynamic model to investigate the feedback between salt‐marsh erosion and hydrodynamic changes in the Venice Lagoon, a large microtidal back‐barrier system in northeastern Italy. Numerical simulations are carried out for past morphological configurations of the lagoon dating back up to 1887, as well as for hypothetical scenarios involving additional marsh erosion relative to the present‐day conditions. The progressive loss of salt marshes significantly impacted the lagoon hydrodynamics, both directly and indirectly, by amplifying high‐tide water levels, reducing wind‐wave energy dissipation, and critically affecting tidal asymmetries across the lagoon. Restoration projects and manmade protection of marsh margins, which have been implemented over the past few decades, limited the detrimental effects of marsh loss on the lagoon hydrodynamics, while not substantially changing the risk of flooding in urban lagoon settlements. Compared to previous studies, our analyses suggest that the hydrodynamic response of back‐barrier systems to salt‐marsh erosion is extremely site‐specific, depending closely on the morphological characteristics of the embayment as well as on the external tidal and wind forcings.
Disengagement and loss to follow-up in intravitreal injection clinics for neovascular age-related macular degeneration
Authors: Jones Rebecca , Stratton Irene M. , Scanlon Peter H. , Theodoropoulou Sofia 
Published: March 2023

Abstract
Background/Objectives
Timely assessment and treatment of patients with neovascular AMD (nAMD) are crucial to preservation of vision. Loss to follow up (LTFU) in these patients is a problem but this has not been systematically investigated.

Subjects/Methods
A retrospective review of electronic medical records of patients with nAMD first treated with anti-VEGF therapy from 1st Jan 2014 to 31st Dec 2018, was conducted in January 2021. Any patient not seen for more than 12 months was classed as no longer attending.

Results
Of the 1328 patients who attended between 2014 and 2018, 348 had failed to attend and were eligible for inclusion in this study. Reasons noted for discontinuation of care: discharged by clinician (33.3%), died (20.7%), moved to another unit outside of area (17.5%), stopped attending due to ill-health (13.5%), discharged due to failure to attend (5.6%) and patient choice to no longer attend (4.6%). There were 16 (4.6%) who did not receive any further appointments despite clinician request for follow-up. After 5 years, 50.5% of patients were no longer attending for treatment. Age was a factor in failure to attend, with 7 out of 12 patients aged >100 years no longer being followed up, compared to 1 out of 11 of 50–59 year-olds.

Conclusions
When analysing visual outcomes in an AMD service it is important to characterise the patients who are lost to follow up. The outcomes for this group may be avoidably poor and understanding the factors influencing LTFU rate is crucial to addressing shortcomings in a hospital AMD service.
Noninvasive electromyometrial imaging of human uterine maturation during term labor
Authors: Wang Hui , Wen Zichao , Wu Wenjie , Sun Zhexian , Kisrieva-Ware Zulfia , Lin Yiqi , Wang Sicheng , Gao Hansong , Xu Haonan , Zhao Peinan , Wang Qing , Macones George A. , Schwartz Alan L. , Cuculich Phillip , Cahill Alison G. , Wang Yong 
Published: March 2023

AbstractElectromyometrial imaging (EMMI) was recently developed to image the three-dimensional (3D) uterine electrical activation during contractions noninvasively and accurately in sheep. Herein we describe the development and application of a human EMMI system to image and evaluate 3D uterine electrical activation patterns at high spatial and temporal resolution during human term labor. We demonstrate the successful integration of the human EMMI system during subjects’ clinical visits to generate noninvasively the uterine surface electrical potential maps, electrograms, and activation sequence through an inverse solution using up to 192 electrodes distributed around the abdomen surface. Quantitative indices, including the uterine activation curve, are developed and defined to characterize uterine surface contraction patterns. We thus show that the human EMMI system can provide detailed 3D images and quantification of uterine contractions as well as novel insights into the role of human uterine maturation during labor progression.
Regional clozapine, ECT and lithium usage inversely associated with excess suicide rates in male adolescents
Authors: Desai Boström Adrian E. , Andersson Peter , Rask-Andersen Mathias , Jarbin Håkan , Lundberg Johan , Jokinen Jussi 
Published: March 2023

AbstractAdvanced psychiatric treatments remain uncertain in preventing suicide among adolescents. Across the 21 Swedish regions, using nationwide registers between 2016–2020, we found negative correlation between adolescent excess suicide mortality (AESM) and regional frequencies of clozapine, ECT, and lithium (CEL) usage among adolescents (β = −0.613, p = 0.0003, 95% CI: −0.338, −0.889) and males (β = −0.404, p = 0.009, 95% CI: −0.130, −0.678). No correlation was found among females (p = 0.197). Highest CEL usage among male adolescents was seen in regions with lowest quartile (Q1) AESM (W = 74, p = 0.012). Regional CEL treatment frequency in 15–19-year-olds was related to lower AESM in males, reflecting potential treatment efficacy, treatment compliance or better-quality mental health care. Suicide prevention may benefit from early recognition and CEL treatment for severe mental illness in male adolescents. The results indicate association but further research, using independent samples and both prospective and observational methodologies, is needed to confirm causality.
Polarization-directed growth of spiral nanostructures by laser direct writing with vector beams
Authors: Lu Xiaolin , Wang Xujie , Wang Shuangshuang , Ding Tao 
Published: March 2023

AbstractChirality is pivotal in nature which attracts wide research interests from all disciplines and creating chiral matter is one of the central themes for chemists and material scientists. Despite of significant efforts, a simple, cost-effective and general method that can produce different kinds of chiral metamaterials with high regularity and tailorability is still demanding but greatly missing. Here, we introduce polarization-directed growth of spiral nanostructures via vector beams, which is simple, tailorable and generally applicable to both plasmonic and dielectric materials. The self-aligned near field enhances the photochemical growth along the polarization, which is crucial for the oriented growth. The obtained plasmonic chiral nanostructures present prominent optical activity with a g-factor up to 0.4, which can be tuned by adjusting the spirality of the vector beams. These spiral plasmonic nanostructures can be used for the sensing of different chiral enantiomers. The dielectric chiral metasurfaces can also be formed in arrays of sub-mm scale, which exhibit a g-factor over 0.1. However, photoluminescence of chiral cadmium sulfide presents a very weak luminescence g-factor with the excitation of linearly polarized light. A number of applications can be envisioned with these chiral nanostructures such as chiral sensing, chiral separation and chiral information storage.
Natural resources modulate the nexus between environmental shocks and human mobility
Authors: Brottrager Michael , Crespo Cuaresma Jesus , Kniveton Dominic , Ali Saleem H. 
Published: March 2023

AbstractIn the context of natural resource degradation, migration can act as means of adaptation both for those leaving and those supported by remittances. Migration can also result from an inability to adapt in-situ, with people forced to move, sometimes to situations of worse or of the same exposure to environmental threats. The deleterious impacts of resource degradation have been proposed in some situations to limit the ability to move. In this contribution, we use remote sensed information coupled with population density data for continental Africa to assess quantitatively the prevalence of migration and immobility in the context of one cause of resource degradation: drought. We find that the effect of drought on mobility is amplified with the frequency at which droughts are experienced and that higher income households appear more resilient to climatic shocks and are less likely to resort to mobility as an adaptation response.
BRD9-mediated chromatin remodeling suppresses osteoclastogenesis through negative feedback mechanism
Authors: Du Jiahui , Liu Yili , Wu Xiaolin , Sun Jinrui , Shi Junfeng , Zhang Hongming , Zheng Ao , Zhou Mingliang , Jiang Xinquan 
Published: March 2023

AbstractBromodomain-containing protein 9 (BRD9), a component of non-canonical BAF chromatin remodeling complex, has been identified as a critical therapeutic target in hematological diseases. Despite the hematopoietic origin of osteoclasts, the role of BRD9 in osteoclastogenesis and bone diseases remains unresolved. Here, we show Brd9 deficiency in myeloid lineage enhances osteoclast lineage commitment and bone resorption through downregulating interferon-beta (IFN-β) signaling with released constraint on osteoclastogenesis. Notably, we show that BRD9 interacts with transcription factor FOXP1 activating Stat1 transcription and IFN-β signaling thereafter. Besides, function specificity of BRD9 distinguished from BRD4 during osteoclastogenesis has been evaluated. Leveraging advantages of pharmacological modulation of BRD9 and flexible injectable silk fibroin hydrogel, we design a local deliver system for effectively mitigating zoledronate related osteonecrosis of the jaw and alleviating acute bone loss in lipopolysaccharide-induced localized aggressive periodontitis. Overall, these results demonstrate the function of BRD9 in osteoclastogenesis and its therapeutic potential for bone diseases.
Risk factors for, and prediction of, exertional heat illness in Thoroughbred racehorses at British racecourses
Authors: Trigg Leah E , Lyons Sally , Mullan Siobhan 
Published: March 2023

AbstractThe development of exertional heat illness (EHI) is a health, welfare and performance concern for racehorses. However, there has been limited multivariable assessment of the possible risk factors for EHI in racehorses, despite such information being vital for regulators to effectively manage the condition. Consequently, this study aimed to identify the risk factors associated with the occurrence of EHI in Thoroughbred racehorses and assess the ability of the risk factor model to predict the occurrence of EHI in racehorses to assist in early identification. Runners at British racecourses recorded in the British Horseracing Authority database between 1st July 2010 and 30th April 2018 were used to model the probability that a horse would present with EHI as a function of a suite of environmental, horse level and race level factors. EHI was reported in 0.1% of runners. Race distance, wet bulb globe temperature, preceding 5-day temperature average, occurrence of a previous EHI incident, going, year and race off time were identified as risk factors for EHI. The model performed better than chance in classifying incidents with a mean area under the receiver operating characteristic curve score of 0.884 (SD = 0.02) but had a large number of false positives. The results provide vital evidence for industry on the need to provide appropriate cool down facilities, identify horses that have repeated EHI incidents for early intervention, and collect new data streams such as on course wet bulb globe temperature measurements. The results are especially relevant as the sport is operating in a changing climate and must mitigate against more extreme and longer spells of hot weather.
Wavelet-artificial neural network to predict the acetone sensing by indium oxide/iron oxide nanocomposites
Authors: Iranmanesh Reza , Pourahmad Afham , Shabestani Danial Soltani , Jazayeri Seyed Sajjad , Sadeqi Hamed , Akhavan Javid , Tounsi Abdelouahed 
Published: March 2023

AbstractThis study applies a hybridized wavelet transform-artificial neural network (WT-ANN) model to simulate the acetone detecting ability of the Indium oxide/Iron oxide (In2O3/Fe2O3) nanocomposite sensors. The WT-ANN has been constructed to extract the sensor resistance ratio (SRR) in the air with respect to the acetone from the nanocomposite chemistry, operating temperature, and acetone concentration. The performed sensitivity analyses demonstrate that a single hidden layer WT-ANN with nine nodes is the highest accurate model for automating the acetone-detecting ability of the In2O3/Fe2O3 sensors. Furthermore, the genetic algorithm has fine-tuned the shape-related parameters of the B-spline wavelet transfer function. This model accurately predicts the SRR of the 119 nanocomposite sensors with a mean absolute error of 0.7, absolute average relative deviation of 10.12%, root mean squared error of 1.14, and correlation coefficient of 0.95813. The In2O3-based nanocomposite with a 15 mol percent of Fe2O3 is the best sensor for detecting acetone at wide temperatures and concentration ranges. This type of reliable estimator is a step toward fully automating the gas-detecting ability of In2O3/Fe2O3 nanocomposite sensors.
Mindfulness may be associated with less prosocial engagement among high intelligence individuals
Authors: Guo Qingke , Li Sisi , Liang Jingu , Yu Xinxin , Lv Yiqing 
Published: March 2023

AbstractThis study examined the role of dispositional mindfulness in the association between intelligence and prosocial behavior. A total of 759 college students (mean age is 22.03; 477 females) participated in exchange for extra credit in psychology course. The results confirmed a positive relationship between intelligence and prosocial behavior as revealed by many studies, with empathy serving as a potential mediator. Mindfulness negatively moderated all the hypothesized pathways between research variables. Specifically, with the increase of the levels of dispositional mindfulness, (1) the intelligence-prosociality association changed from positive to negative, (2) the intelligence-empathy association changed from positively significant to insignificant, (3) the empathy-prosociality association changed from stronger to weaker. These findings may suggest some limitations of mindfulness. That is, present moment awareness and acceptance of the status quo may result in reduced arousal when witnessing others suffering, thereby preventing high intelligence individuals from helping the sufferers to get rid of trouble.
Use of dual genomic sequencing to screen mitochondrial diseases in pediatrics: a retrospective analysis
Authors: Wu Teng-Hui , Peng Jing , Yang Li , Chen Yan-Hui , Lu Xiu-Lan , Huang Jiao-Tian , You Jie-Yu , Ou-Yang Wen-Xian , Sun Yue-Yu , Xue Yi-Nan , Mao Xiao , Yan Hui-Ming , Ren Rong-Na , Xie Jing , Chen Zhi-Heng , Zhang Victor-Wei , Lyu Gui-Zhen , He Fang 
Published: March 2023

AbstractMitochondrial diseases (MDs) were a large group multisystem disorders, attributable in part to the dual genomic control. The advent of massively sequencing has improved diagnostic rates and speed, and was increasingly being used as a first-line diagnostic test. Paediatric patients (aged < 18 years) who underwent dual genomic sequencing were enrolled in this retrospective multicentre study. We evaluated the mitochondrial disease criteria (MDC) and molecular diagnostic yield of dual genomic sequencing. Causative variants were identified in 177 out of 503 (35.2%) patients using dual genomic sequencing. Forty-six patients (9.1%) had mitochondria-related variants, including 25 patients with nuclear DNA (nDNA) variants, 15 with mitochondrial DNA (mtDNA) variants, and six with dual genomic variants (MT-ND6 and POLG; MT-ND5 and RARS2; MT-TL1 and NARS2; MT-CO2 and NDUFS1; MT-CYB and SMARCA2; and CHRNA4 and MT-CO3). Based on the MDC, 15.2% of the patients with mitochondria-related variants were classified as “unlikely to have mitochondrial disorder”. Moreover, 4.5% of the patients with non-mitochondria-related variants and 1.43% with negative genetic tests, were classified as “probably having mitochondrial disorder”. Dual genomic sequencing in suspected MDs provided a more comprehensive and accurate diagnosis for pediatric patients, especially for patients with dual genomic variants.
Development and validation of deep learning based embryo selection across multiple days of transfer
Authors: Theilgaard Lassen Jacob , Fly Kragh Mikkel , Rimestad Jens , Nygård Johansen Martin , Berntsen Jørgen 
Published: March 2023

AbstractThis work describes the development and validation of a fully automated deep learning model, iDAScore v2.0, for the evaluation of human embryos incubated for 2, 3, and 5 or more days. We trained and evaluated the model on an extensive and diverse dataset including 181,428 embryos from 22 IVF clinics across the world. To discriminate the transferred embryos with known outcome, we show areas under the receiver operating curve ranging from 0.621 to 0.707 depending on the day of transfer. Predictive performance increased over time and showed a strong correlation with morphokinetic parameters. The model’s performance is equivalent to the KIDScore D3 model on day 3 embryos while it significantly surpasses the performance of KIDScore D5 v3 on day 5+ embryos. This model provides an analysis of time-lapse sequences without the need for user input, and provides a reliable method for ranking embryos for their likelihood of implantation, at both cleavage and blastocyst stages. This greatly improves embryo grading consistency and saves time compared to traditional embryo evaluation methods.
Erbium-doped (Pb0.9-Er0.01-Zr0.09) and (Pb0.9-Er0.01-Zr0.045-Ti0.045) nano-crystalline films and nano-rods ceramic synthesis by sol–gel technique for energy-storage application
Authors: Ibrahim F. A. , El-Desoky M. M. 
Published: March 2023

AbstractThe development of dielectric constant materials for energy storage applications is in high demand. Lead zirconate and lead zirconate titanate doping with erbium thin films and bulk-based devices with variant dielectric constant were created in this work. Pb(0.9)-Er0.01Zr(0.09) (PEZ) and Pb0.9-Er0.01-Zr0.045-Ti0.045 (PEZT) thin films were produced on a glass substrate using a sol–gel doctor blade technique at low temperature. X-ray diffraction (XRD), transmission electron microscopy (TEM), and electron diffraction (ED) were used to examine the structure of the produced nanocrystals. PEZ and PEZT films had nanocrystals that were 9.5 nm and 15 nm in size, respectively, whereas PEZ and PEZT bulk nano-rods had 455 ± 5 nm in length and 45 ± 1 nm in diameter. The TEM and XRD results were found to be completely consistent in terms of particle size. Ferroelectric properties and dielectric characteristics were found to be frequency dependent. Dielectric experiments revealed that the dielectric constant was decreasing for bulk samples compared to film samples. The energy-storage efficiency of PEZ films was roughly 66.01%, and 67.8% for PEZT. The residual polarization of the Er-doped PEZ and PEZT films was the highest, reaching 36.25 μC/cm2 and 69.79 μC/cm2, respectively, and the coercive fields were 43 kV/cm and 45.43 kV/cm, respectively. On the other hand, PEZ and PEZT bulk samples had residual polarizations of 27.15 μC/cm2 and 37.29 μC/cm2, respectively, while having coercive fields of 32.3 kV/cm and 39.3 kV/cm, respectively. It was found that (PEZ) and (PEZT) samples may have potential use in energy storage applications.
Histologic and histomorphometric evaluation of Aloe vera adjunctive to β-tricalcium phosphate in class II furcation defects in dogs
Authors: Taalab Maha R. , Rehim Samia S. Abd El , Eldeeb Dina W. , El-Moslemany Riham M. , Abdelrahman Hams 
Published: March 2023

AbstractAloe vera has antimicrobial activity and enhances the osseointegration process, thus it may have the potential in treating periodontal defects. This study aimed to evaluate the effect of Aloe vera as an adjunction to Beta-tricalcium phosphate (β-TCP) bone graft in Grade II furcation defects. A randomized study was conducted on six healthy mongrel dogs' premolars. A total of twenty-four Grade II furcation critical-sized defects were surgically created after reflecting a full-thickness flap, twelve defects were filled with β-TCP while the other twelve defects were filled with Aloe vera mixed with β-TCP and both covered by collagen membrane. Animals were euthanized at the end of the fourth and eighth week and defects were analyzed histologically and histomorphometrically. Histologically, Aloe vera mixed with β-TCP resulted in more bone formation and new PDL fibers compared to β-TCP alone. After 2 and 4 weeks, the experimental group had significantly higher newly formed interradicular bone height (p < 0.0001, and p < 0.0001, respectively), bone thickness (p < 0.0001, and p < 0.0001, respectively), and percentage of the surface area (p = 0.009, and p = 0.023, respectively). Aloe vera gel adjunctive to β-TCP is an effective bioactive agent that enhances periodontal tissue regeneration and bone formation in critically sized defects.