bluuebunny/crossref_metadata_2025_split huggingface dataset:
Discovery and evaluation of active compounds from Xuanfei Baidu Formula against COVID-19 via SARS-Cov-2 Mpro
Authors: Zhang Min , Liu Liting , Zhao Yao , Cao Yipeng , Zhu Yan , Han Lifeng , Yang Qi , Wang Yu , Dang Ruoyu , Wang Changjian , Zhang Han , Wang Yuefei , Zhang Junhua 
Published: April 2023

Abstract
Background The coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus (SARS-CoV-2) is still a widespread concern. As one of the effective traditional Chinese medicine (TCM) formula, Xuanfei Baidu formula (XFBD) shows significant efficacy for treatment of COVID-19 patients. However, its antiviral compounds and mechanism are still unclear.
Purpose: In this study, we explored the bioactive compounds of XFBD and its antiviral mechanism by integrating computational analysis and experimental testing.
Methods Aiming at the SARS-CoV-2 main protease (Mpro), as a key target in virus replication, the fluorescence resonance energy transfer (FRET) assay was built to screen out satisfactory natural inhibitors from XFBD. The surface plasmon resonance (SPR) and isothermal titration calorimetry (ITC) were undertaken to verify the binding affinity of Mpro-ligand. Omicron BA.1.1 and BA.2 variants were used to evaluate the antiviral activity of the focused compounds in non-cytotoxicity concentrations. For introducing the molecular mechanism, computational modeling and NMR spectra were employed to predict the binding mode and binding site of Mpro-ligand.
Results From a library of 83 natural compounds, acteoside, licochalcone B, licochalcone D, linoleic acid, and physcion showed the satisfactory inhibition effect on Mpro with IC50 from 1.93 to 42.96 µM, which were further verified by SPR. Showing the excellent binding affinity, acteoside was witnessed to gain valuable insights into the thermodynamic signatures by ITC and presented antiviral activity on Omicron BA.1.1 and BA.2.3 variants in vitro. The results revealed that acteoside inhibited Mpro via forming the hydrogen bond between 7-H of acteoside and Mpro.
Conclusion Acteoside is regarded as a representative active natural compound in XFBD to inhibit replication of SARS-CoV-2, which provides the antiviral evidence and some insight into the identifications of SARS-CoV-2 Mpro natural inhibitors.
Paranormal beliefs are driving the bias seen in the classification of ambiguous stimuli in perceptual decision-making paradigm
Authors: Narmashiri Abdolvahed , Sohrabi Ahmad , Hatami Javad 
Published: April 2023

Abstract

Previous studies showed that paranormal believers are more tendency to find meaningful patterns in noise. This study develops these results via examine the sensory biases correlated to paranormal beliefs by using a perceptual decision-making task. To investigate whether paranormal believers differ in their sensitivity to recognizing significant face and house patterns in visual noise levels (from 40–70%), we used a face/house categorization task. The results show that paranormal believers are less efficient at discrimination between face and house stimulus in visual noise levels. It reflects a correlation between paranormal beliefs and a tendency for ambiguous stimuli. Our results revealed that paranormal beliefs are effective in face/house categorization task in the perceptual decision-making paradigm. Also, these findings show the effects of prior beliefs on cognitive processes and emphasize the influence of personal characteristics such as gender, age, and education on paranormal beliefs.
The Sensitivity of the North American Monsoon to Gulf of California Sea Surface Temperatures
Authors: Wallace Brendan , Minder Justin 
Published: April 2023

Abstract
The sensitivity of North American Monsoon rainfall to sea surface temperatures (SST) in the Gulf of California (GoC) is assessed using a set of convection-permitting regional climate models. Simulations are performed from May through September 1994 and consist of one control run and two experimental runs that positively and negatively perturb SSTs exclusively within the GoC. Averaged across the season, rainfall increases by 23% in response to spatial mean warming of 1.4 K for the GoC. The direct conversion of GoC moisture into precipitation accounts for 19% of this total increase in rainfall. Increases in rainfall early in the season are more strongly supported by changes in mean thermodynamics that favor stronger moisture flux convergence. Additionally, enhanced inland moisture transport from the GoC increases the amount of convective available potential energy across the region and allows for stronger vertical convective fluxes that intensifies precipitation. A secondary mean circulation response also favors greater precipitation and is related to the advection of cooler air off the mountains of the Sierre Madre Occidental over the GoC. This cooler air mass lowers geopotential heights and drives a cyclonic wind anomaly that favors enhanced flow from the GoC towards the Sierre Madre Occidental mountain range. Later in the season, comparatively smaller increases in rainfall are attributed to increases in local terrestrial evaporation that serve as a positive feedback to initial increases in rainfall driven by perturbed SSTs.
Polyurea Membrane as potential purifying technology for Water Cleaning: Kinetic and Equilibrium Modeling of Dyes Adsorption
Authors: Calvo Pablo , de Oliveira Lilian , Oliveira Nicole , Molina Eduardo Ferreira 
Published: April 2023

Abstract
A treatment of water from aqueous solutions was reported in this work using polyurea (PU) as a novel adsorbent. Dyes with different characteristics (Congo red (CR) and methylene blue (MB)) were examined for their adsorption on polyurea. The PU membrane was achieved by a reaction between a polyetheramine and polyisocyanate using sol-gel chemistry. FTIR results confirmed the formation of urea groups, and the polymeric membrane showed high homogeneity, making it a viable purifying technology for wastewater. The high swelling capacity of the membrane showed an important role in CR dye diffusion/adsorption. PU membranes exhibited excellent adsorption to CR anionic dye, with a removal efficiency of more than 85%. However, MB dye adsorption was not favorable, suggesting a high affinity with anionic species. Adsorption of CR dye onto PU followed the pseudo-second order kinetic and Langmuir isotherm models. The intraparticle diffusion model demonstrated that the swelling of PU facilitated the asorption/diffusion process and accelerated the mass transfer of the CR dye onto the membrane. Our findings suggest that PU membranes derived from commercially available reagents are promising for the decontamination of dye wastewater.
Experiences of Nurses and Midwives with the Use of Indecorously Structured Duty Rosters at Selected Health Facilities in Ho, Volta Region of Ghana: A Qualitative Study
Authors: Dartey Anita Fafa , Tackie Vivian , Lotse Comfort Worna , Sagbo Francis Mawougnon , Dodoo Lily 
Published: April 2023

Abstract
Background Decent working time in the health sector is critical to providing quality care. It balances health workers’ well-being with health service requirements, including providing healthcare 24 hours a day, seven days a week. Nursing and midwifery staff form the largest group in the health workforce, and comprehending their experience and challenges around duty roster is critical to effectively improving and enhancing nurses’ work conditions, and job satisfaction and increasing the quality of care. The purpose of this study was to describe the lived experiences of nurses and midwives using indecorously structured hospital duty rosters at selected health facilities in Ho, the Volta Region of Ghana.Method A descriptive qualitative design was used to explore the experiences of nurses and midwives with the hospital duty roster at selected health facilities in Ho, the Volta Region of Ghana. A semi-structured interview guide was used to collect the data and transcribed verbatim. The data were analyzed using thematic analysis by a deductive approach. The researchers read through the raw data and created a list of initial codes to represent new concepts of interest.Results It was found that the duty roster is often organized in ways that are detrimental to nurses’ and midwives’ health and wellbeing, their job performance, and subsequently, to the patient care they provide. Also, nurses and midwives are at considerable risk for work-related stress, burnout, and mental health problems as they do not employ effective coping strategies toward the hospital duty roster.Conclusion Our findings highlight several factors that may be important in influencing nurses’ choice of shift patterns and the resulting outcomes for quality of care and the staff themselves. Further research should explore the extent to which nurses’ preferences are considered when designing the hospital duty roster.
A Boolean Circuit-Based Revocable Ciphertext Policy Attribute-Based Encryption Scheme
Authors: Ma Chao , Gao Haiying , Hu Bin 
Published: April 2023

Abstract

Attribute-based encryption is a new cryptosystem that supports fine-grained access control of cloud data, and its access control function is realized through the interaction of attributes and access structures. To achieve more flexible access control, attribute revocation has become an important problem that must be considered in the application process of attribute-based encryption. We propose and implement an efficient revocable ciphertext policy attribute-based encryption scheme based on the improvement of the scheme proposed by Tomida et al. Our scheme has the following features: (i) it is adaptively secure under the Matrix Decisional Diffie-Hellman assumption; (ii) it supports the multi-use of attribute class and the negation of attribute value; (iii) it supports the revocation of system attributes. (iv) the update of the key and ciphertext is completed by the trusted center and the cloud server respectively, which reduces the revocation overhead for users.
The optimization of residual stress in arc bridge Hastelloy X components fabricated by Laser Powder Bed Fusion
Authors: Liu Yi , Fang Xuewei , Li XinZhi , Huang Ke 
Published: April 2023

Abstract
Laser Powder Bed Fusion (L-PBF) has been widely used in various fields, but due to the inherent complex thermal history and ultra-high solidification rate in the L-PBF process, detrimental residual stresses inevitably form inside the component. In this study, the formation mechanisms of residual stress and the strategies to reduce them were investigated during L-PBF of Hastelloy components. Components with simple block geometry were first fabricated with different deposition strategies, i.e., scanning island size and rotation angle. The microstructure and residual stress of these samples were characterized. The optimal deposition strategy in terms of maximum tensile residual stress was then used to deposit the arc bridge components with complex geometry. The results clearly show that different deposition strategy is needed for components with complex geometry due to the change in cross-sectional area and the different heat transfer behavior between the new deposition layer and the previously deposited solid layer. Finally, the arch bridge samples with no warping deformation were achieved by optimized random scanning strategies and crossline scanning strategies. The results provided in this study thus provide a theoretical basis for tailoring residual stress during L-PBF of complex components.
APE1 promotes radiation resistance against radiation-induced pyroptosis by inhibiting the STING pathway in lung adenocarcinoma
Authors: Zhou Jing , Wei Zixin , Yang Chuan , Jia Dexin , Pan Bo , Zeng Yuan , Sun Di , Yu Yan 
Published: April 2023

Abstract
Background: Mammalian apurinic/apyrimidinic endonuclease 1 (APE1, APEX1) is a multifunctional enzyme that maintains cell homeostasis. It is involved in the base excision repair (BER) pathway and plays a key role in radiation-induced DNA damage response. Nevertheless, the relationship between APE1-driven radiation resistance and pyroptosis in lung adenocarcinoma (LUAD) cells and the underlying molecular mechanisms remain unclear.
Methods: The up-regulated expression gene APE1 that was screened out through differential expression analysis of biogenic data and RNA-seq results. The q-PCR experiments and immunohistochemical these two techniques were used to detect its expression both in lung adenocarcinoma and normal lung tissues. The effect of APE1 on the proliferation was determined by two experiments as CCK-8 and EdU. The Transwell and scratch tests were both used to evaluate the invasion and migration ability. The effect of APE1 on DNA damage and radiotherapy sensitivity was determined by clonal formation, immunofluorescence and flow cytometry. Through biogenic analysis and enrichment of APE1 related molecules and pathways, the regulation of APE1 on STING and its downstream signaling pathways was verified by western blot. In addition, APE1 directly interacts with AIM2 and DDX41 detected by RNA-seq and co-immunoprecipitation to inactivate the interferon gene stimulating factor (STING) pathway, thereby inhibiting pyroptosis after radiotherapy. The effect of APE1 on tumor occurrence and radiotherapy in vivo was observed in nude mouse model.
Results: The expression level of APE1 was significantly increased in LUAD and can promote the activity levels of proliferation, migration and invasion in LUAD cells. APE1 plays an anti-radiation role by regulating STING pathway through DDX41. APE1 can induce pyroptosis of cells after radiotherapy through AIM2; APE1 can promote tumor generation, enhance tumor load and inhibit radiosensitivity in vivo.
Conclusions: APE1 protects LUAD cells against radiation-induced damage and induces radio-resistance by targeting the STING pathway. could induce pyroptosis and negatively regulate by interaction with AIM2 and DDX41. APE1 inhibitors should be considered for enhancing the radiosensitivity of LUAD cells and improving patient prognosis and therapeutic outcomes. Thus, APE1 may play a role in affecting tumor immune microenvironment and tumor immunotherapy.
The Ljubljana 1895 earthquake: source parametres from the inversion of macroseismic data
Authors: Jukić Ivana , Pettenati Franco , Sirovich Livio , Cecić Ina , Costa Giovanni , Suhadolc Peter 
Published: April 2023

Abstract
The 14 April 1895 earthquake (Mw 6.1, in the Ljubljana area, Slovenia) is still not fully explained. The aim of this paper is to derive information on its source from the inversion of an updated dataset of intensities (evaluated using EMS-98). This was done by the KF-NGA automatic non-linear geophysical inversion, with a Niching Genetic Algorithm technique, already presented in other articles. The distribution of damage caused by this earthquake is not homogeneous, often with significant differences of intensity between neighboring sites. The statistical analysis of intensities, epicentral distances and sites geology suggests some site effects. Despite this, the resulting solution is compatible with the regional seismotectonics, i.e. an almost pure dip-slip mechanism: strike angle 282°5°, dip 38°±7°, rake 86°±9° (±180° because of the intrinsic ambiguity of the KF-NGA inversion). Since the rake angle is close to 90°, there is an almost perfect ambiguity between the two planes of the focal mechanism. Thus, our solution has a Dinaric direction and could be associated with either a fault plane dipping NE or with one dipping SW.
Fuzzy Second Order Change in Home Energy Economy: Photovoltaic cells for sustainability in Mexico
Authors: Rivera Rubén Chávez , Brotons-Martínez José Manuel , Ramos-Sánchez Jesús Ricardo 
Published: April 2023

Abstract
According to the Comisión Federal de Electricidad (CFE) in Mexico, despite high investment costs and the lack of confidence in photovoltaics (PV) technology, the number of PV users has increased in recent years. In many cases, expected savings are not achieved, which can be put down to shortcomings in maintenance, an insufficient number of PVs, or obsolete equipment, among others. We consider three sets of factors that affect energy saving and sustainability: collateral factors, cognitive factors, and strategic change. The learning process approach is divided into two stages: first and second-order learning. We use fuzzy logic, fuzzy hamming distance and neural networks to emulate training - learning by analyzing the homeostatic sensitivity of the alpha coefficient in the transformation from first order to second order change through mean squared error and application of the backpropagation algorithm. Energy consumption records indicate that the oldest installations do not achieve energy saving due to bad practices in energy consumption and poor equipment maintenance. We found there was a positive disposition towards technological changes, while influencing others to decrease electricity consumption is weak. Evolution of training can be measured by a decrease in mean squared error, and the homeostatic process can be measured by applying α coefficient.
Brain radiotherapy and anlotinib had a good intracranial control on primary cardiac angiosarcoma with multiple metastases: a case report
Authors: Ma Ying-Ying , Li Zhi-Ke , Liao Zi-Yi , Peng Yang , Ma Dai-Yuan 
Published: April 2023

Abstract
Primary cardiac angiosarcoma (PCA) is a relatively rare and fatal disease with poor prognosis. It remains controversial whether its survival can be improved with additional treatment besides complete surgical excision. In this case,we presented a 52-year-old man with PCA in the right atrial who underwent a palliative resection, but suffered from metastases of the brain, lung and liver rapidly. He accepted multi-mode combination therapy including first-line chemotherapy, second-line anlotinib which was not only concurrent with brain radiotherapy but also concurrent with immunotherapy in the end. Although anlotinib combined with brain radiotherapy had a effectively control on the intracranial lesions, progression free survival was 5 months. But overall survival didn’t significantly prolonged, for he only survived for 12 months. In conclusion, the treatment for those metastatic PCA still needs further exploration.
Understanding preferences of stroke survivors for feedback provision about functional movement behavior from wearable sensors: a mixed-methods study
Authors: Demers Marika , Cain Amelia , Bishop Lauri , Gunby Tanisha , Rowe Justin B , Zondervan Daniel , Winstein Carolee J 
Published: April 2023

Abstract
Background In stroke rehabilitation, wearable technology can be used as an intervention modality by providing timely, meaningful feedback on motor performance. Stroke survivors’ preferences may offer a unique perspective on what metrics are intuitive, actionable, and meaningful to change behavior. However, few studies have identified feedback preferences from stroke survivors. This project aims to determine stroke survivors’ satisfaction with feedback from wearable sensors (both mobility and arm/hand use) and to identify preferences for feedback type and delivery schedule.Methods A sample of 30 chronic stroke survivors wore a multi-sensor system in the natural environment over a 1-week monitoring period. The sensor system captured time in active movement of each arm, arm use ratio, step counts and stance time symmetry. Using the data from the monitoring period, participants were presented with a movement report with visual displays of quantitative and qualitative feedback. A survey and qualitative interview were used to assess ease of understanding, actionability and components of feedback that users found most meaningful to drive lasting behavior change.Results Arm/hand use and mobility sensor-derived feedback metrics were easy to understand and actionable. The preferred metric to encourage arm/hand use was the hourly arm use bar plot, and similarly the preferred metric to encourage mobility was the hourly steps bar plot, which were each ranked as top choice by 40% of participants. Participants perceived that quantitative (i.e., step counts) and qualitative (i.e., stance time symmetry) mobility metrics provided complementary information. Three main themes emerged from the qualitative analysis: 1) Motivation for behavior change, 2) Real-time feedback based on individual goals, and 3) Value of experienced clinicians for prescription and accountability. Participants stressed the importance of having feedback tailored to their own personalized goals and receiving guidance from clinicians on strategies to progress and increase functional movement behavior in the unsupervised home and community setting.Conclusion The resulting technology has the potential to integrate engineering and personalized rehabilitation to maximize participation in meaningful life activities outside clinical settings in a less structured environment—one where stroke survivors live their lives.
Multicenter Real-World Study of Huaiqihuang Granules in the Treatment of Pediatric Henoch-Schonlein Purpura Nephritis
Authors: Tang Ying , Wu Yubin 
Published: April 2023

Abstract
Background: Henoch-Schonlein purpura nephritis (HSPN) is one of the most common secondary glomerular diseases. Effective treatment of HSPN is particularly important. The therapeutic efficacy of Huaiqihuang(HQH) granules for HSPN has only been investigated in small, single-center studies. Multicentered, large sample, real-world study is still lacking.
Methods: In this real-world study, 835 children with HSPN from 21 hospitals were divided into isolated hematuria and proteinuria groups. Patients were treated with Huaiqihuang granules combined with conventional treatment (HQH group) or conventional treatment alone (control group). The remission rate of HQH group and control group were compared using life table method, factors associated with remission were identified using Cox regression analyses, and the incidence of adverse events was observed.
Results: Patients were aged 8.85 ± 2.86 years on average, and 58% were male. In 154 HSPN patients with isolated hematuria. The 12th week remission rate of HQH group was 58.31 %( 95%CI, 49.38%–67.50%) while that in the control group was 26.99 %( 95%CI, 15.03%–45.52%), the hazard ratio(HR) of HQH treatment for hematuria remission was 2.77 (95% CI, 1.57–4.89; p < 0.01) in multivariate Cox regression analysis. Of 681 patients with proteinuria, those treated with HQH had 12th week remission rate of 76.81%( 95% CI,72.97%– 80.45%) while those in the control group was 67.70 %(95% CI, 60.00%–75.18%),the HR of HQH treatment for proteinuria remission was 1.23(95% CI, 1.01–1.50; p = 0.04) in multivariate Cox regression analysis.Stratified analysis indicated in patients with non-nephrotic-range proteinuria, the HR of HQH treatment for proteinuria remission were 1.26 (95% CI, 1.01–1.59; p = 0.04) The incidence of adverse reactions did not differ between the Huaiqihuang and control groups (p < 0.05).
Conclusion: Huaiqihuang granules combined with conventional treatment can significantly increase the remission rate in cases of isolated hematuria HSPN and HSPN with proteinuria and be a protective factor on isolated hematuria HSPN and non-nephrotic-range proteinuria (NNRP)-type HSPN, with good safety.