bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pharmacist review of chronic inhaler therapy appropriateness for hospitalized patients with COPD or asthma
Authors: Parrott Tate D. , Wallace Matthew D. , Niehoff Kristina M. , Eble Sarah H. , Blumenfeld Lauren , Sevin Carla M. , Choma Neesha N. , Gao Yue , Choi Leena , Lindsell Christopher J. , Zuckerman Autumn D. 
Published: July 2023

AbstractPatients with asthma and chronic obstructive pulmonary disease rely on inhaler therapy to reduce disease progression and exacerbation risk. Patients admitted to the hospital are at an increased risk for exacerbations and readmission if their inhaler therapy upon discharge is not aligned with current guidelines and/or affordable. The objective of this study was to assess the appropriateness of the chronic inhaler regimen for patients admitted to the hospital based on clinical practice guidelines and insurance coverage. A sub‐study was designed to analyze a cohort of a single‐center, pragmatic, prospective randomized controlled trial at a large academic medical center. Patients admitted to a medicine service with a pharmacist and prescribed a long‐acting inhaler were included. Participants randomized to a pharmacist‐led intervention were assessed for inhaler appropriateness based on clinical guidelines and patient insurance. The objective of this sub‐study is to assess the number of inhalers identified as inappropriate based on the pharmacist's review. A patient was considered to have an inappropriate inhaler regimen if any of their inhalers were inconsistent with guideline recommendations or not covered by insurance. Descriptive statistics were used to characterize appropriate inhaler use. The study pharmacist reviewed 552 unique inhalers for 348 patients. Overall, 42% of inhalers were inappropriate, affecting 50.3% of participants; 20% of inhalers were inappropriate based on insurance, 26% were inappropriate based on guidelines, and 7% were inappropriate based on both criteria. Recommendations were placed via a pharmacy consult for 198 patients (57%), most recommending an inhaler initiation (55%), followed by inhaler discontinuation (38%). A pharmacist‐led review of chronic inhaler therapy for patients admitted to the hospital identified the need for a change in therapy based on financial or clinical guidelines in over half of the patients reviewed. Interventions to increase the appropriateness of prescribed inhalers are needed to reduce disease progression and disease exacerbation.
Tendon‐derived matrix crosslinking techniques for electrospun multi‐layered scaffolds
Authors: Jenkins Thomas L. , Sarmiento Huertas Paula A. , Umemori Kentaro , Guilak Farshid , Little Dianne 
Published: July 2023

AbstractTendon tears are common and healing often occurs incompletely and by fibrosis. Tissue engineering seeks to improve repair, and one approach under investigation uses cell‐seeded scaffolds containing biomimetic factors. Retention of biomimetic factors on the scaffolds is likely critical to maximize their benefit, while minimizing the risk of adverse effects, and without losing the beneficial effects of the biomimetic factors. The aim of the current study was to evaluate cross‐linking methods to enhance the retention of tendon‐derived matrix (TDM) on electrospun poly(ε‐caprolactone) (PCL) scaffolds. We tested the effects of ultraviolet (UV) or carbodiimide (EDC:NHS:COOH) crosslinking methods to better retain TDM to the scaffolds and stimulate tendon‐like matrix synthesis. Initially, we tested various crosslinking configurations of carbodiimide (2.5:1:1, 5:2:1, and 10:4:1 EDC:NHS:COOH ratios) and UV (30 s 1 J/cm2, 60 s 1 J/cm2, and 60 s 4 J/cm2) on PCL films compared to un‐crosslinked TDM. We found that no crosslinking tested retained more TDM than coating alone (Kruskal‐Wallis: p > .05), but that human adipose stem cells (hASCs) spread most on the 60 s 1 J/cm2 UV‐ and 2.5:1:1 EDC‐crosslinked films (Kruskal‐Wallis: p < .05). Next, we compared the effects of 60 s 1 J/cm2 UV‐ and 2.5:1:1 EDC‐crosslinked to TDM‐coated and untreated PCL scaffolds on hASC‐induced tendon‐like differentiation. UV‐crosslinked scaffolds had greater modulus and stiffness than PCL or TDM scaffolds, and hASCs spread more on UV‐crosslinked scaffolds (ANOVA: p < .05). Fourier transform infrared spectra revealed that UV‐ or EDC‐crosslinking TDM did not affect the peaks at wavenumbers characteristic of tendon. Crosslinking TDM to electrospun scaffolds improves tendon‐like matrix synthesis, providing a viable strategy for improving retention of TDM on electrospun PCL scaffolds.
Black males and school counselors: Do they experience the culture in counseling programs and departments differently from Black females?
Authors: Bryan Julia , Kim Jungnam , Liu Chang 
Published: July 2023

AbstractThis study examined the effects of school counseling college‐going culture (SCCGC) on Black male students’ college outcomes using a sample from the High School Longitudinal Study, and whether these effects differed for males versus females. Regression analyses revealed that different aspects of SCCGC were more salient for Black males compared to Black females. For example, counselor expectations appeared more important for males and school connectedness for females suggesting the dangers of a one‐size‐fits‐all approach to college going.
Displacement of human milk during fortification: An experimental study
Authors: Bingham Rhyan , Pineda Daphne , Gates Amy , Thompson Amy B. , Stansfield Brian K. 
Published: July 2023

AbstractBackgroundThis study quantified the displacement of human milk by commercial human milk fortifiers (HMFs) and infant formulas.MethodsCommercial liquid HMFs and powder infant formulas were added to pasteurized pooled donor human milk in triplicate, stirred, and weighed. The difference in weight between unfortified and fortified human milk at 22, 24, 26, 27, 28, and 30 kcal/ounce was calculated.ResultsThe displacement of human milk by liquid HMFs and powder infant formulas and powder HMF was highly associated with energy density. A human milk–derived HMF displaced significantly more human milk when compared with bovine milk–derived HMFs at equivalent energy densities. Similarly, powder infant formulas displaced less human milk when compared with a powder HMF, and the addition of hydrolyzed powder infant formulas resulted in less human milk displacement when compared with nonhydrolyzed powder infant formulas.ConclusionsThe displacement of human milk by commercial liquid HMFs and infant formulas must be considered when selecting a fortifying strategy.
Decision tree scoring system to guide selection for consumer preference in sweetpotato breeding trials
Authors: Nakitto Mariam , Ssali Reuben T , Johanningsmeier Suzanne D , Moyo Mukani , de Kock Henriette , Berget Ingunn , Okello Julius J , Mayanja Sarah , Tinyiro Samuel Edgar , Mendes Thiago , Benard Yada , Chelengat Doreen , Osaru Florence , Bugaud Christophe 
Published: July 2023

AbstractBACKGROUNDPreviously, a lexicon and protocol for quantitative descriptive analysis (QDA) was established for the Uganda sweetpotato breeding program. The implication of QDA scores for priority sensory attributes on consumer preference should be determined to interpret results efficiently and make decisions effectively. The present study aimed to develop a gender‐responsive decision tree to obtain an overall sweetpotato eating quality score to facilitate demand‐led targeted breeding selection. It focused on Kamuli and Hoima districts (Uganda) and uses pre‐lease advanced clones (‘NKB3’, ‘NKB105’, ‘NKB135’, ‘D11’ and ‘D20’), released varieties (‘NASPOT 8’ and ‘NAROSPOT 1’) and landraces (‘Muwulu‐Aduduma’, ‘Umbrella’).RESULTSIncluding boiled sweetpotato sensory characteristics, namely mealy, sweet taste, sweetpotato smell, firm and not fibrous, in breeding design would benefit end‐users, especially women given their role in varietal selection, food preparation and marketing. ‘D20’, ‘NASPOT 8’ and ‘NAROSPOT 1’ were most liked in both districts. ‘NKB3’ and ‘D11’ were the least liked in Hoima, whereas ‘Muwulu‐Aduduma’ was the least liked in Kamuli. There was a positive correlation between color and overall liking (r2 = 0.8) and consumers liked the color (average rating ≥ 6 on a nine‐point hedonic scale) of all genotypes. Threshold values (average rating on 11‐point scales) for consumer acceptability were identified (sweet taste = 6, sweetpotato aroma and flavor = 6, firmness = 3, and mealiness = 4). A regression decision tree tool was created to calculate an eating quality selection index when screening lines in breeding programs using the values.CONCLUSIONDecision trees that include consumer needs and gender considerations would facilitate demand‐led breeding and make varietal selection in sweetpotato breeding programs more effective. © 2023 The Authors. Journal of The Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
Inter‐ and Intra‐Operator Variability of Regularized Backscatter Quantitative Ultrasound for the Characterization of Breast Masses
Authors: Argueta‐Lozano Ana K. , Castañeda‐Martinez Laura , Bass Vivian , Mateos Maria‐Julieta , Castillo‐López Jorge P. , Perez‐Badillo M. Patricia , Aguilar‐Cortazar Lesvia O. , Porras‐Reyes Fanny , Sollozo‐Dupont M. Isabel , Torres‐Robles Fabian , Márquez‐Flores Jorge , Villaseñor‐Navarro Yolanda , Esquivel‐Sirvent Raul , Rosado‐Mendez Ivan M. 
Published: July 2023

ObjectivesHere we report on the intra‐ and inter‐operator variability of the backscatter coefficient (BSC) estimated with a new low‐variance quantitative ultrasound (QUS) approach applied to breast lesions in vivo.MethodsRadiofrequency (RF) echo signals were acquired from 29 BIRADS 4 and 5 breast lesions in 2 sequential cohorts following 2 imaging protocols: cohort 1) radial and antiradial views, and cohort 2) short‐ and long‐axis views. Protocol 2 was implemented after retraining and discussion on how to improve reproducibility. Each patient was scanned by at least 2 of 3 radiologists; each performed 3 acquisitions with transducer and patient repositioning in between acquisitions. BSC was estimated using a low‐variance QUS approach based on regularization. Intra‐ and inter‐operator variability of the intra‐lesion median BSC was evaluated with a multifactorial ANOVA test (P‐values) and the intraclass correlation coefficient (ICC).ResultsInter‐operator variability was only significant in the first protocol (P < .007); ICCinter = .77 (95% CI .71–.82), indicating good inter‐operator agreement. In the second protocol, the inter‐operator variability was not significant (P > .05) and agreement was excellent (ICCinter = .92 [.89–.94]). In both protocols, the intra‐operator variability was not significant.ConclusionsOur findings demonstrate the need for standardizing image acquisition protocols for backscatter‐based QUS to reduce inter‐operator variability and ensure its successful translation to the characterization of suspicious breast masses.
RNA sequencing resolves novel DYNC2H1 variants causing short‐rib thoracic dysplasia type 3: Case report
Authors: Marshall Aren E. , MacDonald Stella K. , Liang Yijing , Couse Madeline ,   Care4Rare Canada Consortium, Boycott Kym M. , Richer Julie , Kernohan Kristin D. 
Published: July 2023

AbstractBackgroundIntronic variants outside the canonical splice site are challenging to interpret and therefore likely represent an underreported cause of human disease. Autosomal recessive variants in DYNC2H1 are associated with short‐rib thoracic dysplasia 3 with or without polydactyly (SRTD3), a clinically heterogeneous disease generally presenting with short ribs, shortened tubular bones, narrow thorax and acetabular roof anomalies. We describe a case of SRTD3 with compound heterozygous frameshift and intronic variants and highlight the essential role of RNA sequencing (RNA‐Seq) in variant interpretation.MethodsFollowing inconclusive clinical genetic testing identifying a likely pathogenic frameshift variant and an intronic variant of uncertain significance (VUS) in DYNC2H1 in trans, the family enrolled in the Care4Rare Canada research program, where RNA‐Seq studies were performed.ResultsThe proband presented with post‐axial polydactyly of all four limbs, a significantly small chest with a pectus excavatum and anterior flaring of the ribs. RNA‐Seq investigations revealed a novel splice junction as a result of the intronic VUS and significantly decreased DYNC2H1 gene expression in the proband.ConclusionThis case demonstrates the diagnostic utility of RNA‐Seq for variant interpretation following inconclusive clinical testing, which can ultimately lead to diagnosis for patients with rare disease.
Effect of copepod Apocyclops dengizicus addition on growth, survival, and proximate composition of Macrobrachium rosenbergii postlarvae cultured in brackish-water biofloc system
Authors: Hosain Md. Eilious , Amin S. M. Nurul , Arshad Aziz , Kamarudin Mohd Salleh , Karim Murni , Shohaimi Shamarina , Naser Md. Niamul , Romano Nicholas 
Published: July 2023

Abstract

Objective
The effects of periodically adding the cyclopoid copepod Apocyclops dengizicus (every 4 days at a rate of 4 individuals/mL) with biofloc technology (BFT-C) was compared with conventional biofloc technology (BFT; without copepod) or a clear-water control for Macrobrachium rosenbergii postlarvae nursery culture.

Methods
Survival, growth, proximate composition, and economics of SMacrobrachium rosenbergii postlarvae was calculated. Water quality and biofloc proximate composition were also measured among treatments. For the BFT, maize starch was applied to achieve a C:N ratio of 20:1. Triplicate 125-L polyethylene tanks containing 500 postlarvae each (9.40 ± 1.88 mg) were evaluated.

Result
Specific growth rate was significantly greater in the BFT-C group (8.40 ± 0.24% per day) than BFT (7.23 ± 0.21% per day) and control (7.12 ± 0.42% per day) groups. Postlarvae survival was significantly increased with the BFT-C (94.46%) treatment compared with the BFT (87.33%) and control (82.60%). A significantly lower food conversion ratio (1.08) was obtained in BFT-C than both the BFT (1.73) and control (1.90), possibly due to significantly higher biofloc crude protein and lipid contents in the BFT-C than BFT. Postlarvae whole-body protein and lipid contents were significantly elevated in BFT-C compared to the BFT and control treatments. Economics of gross return, net return, and cost-benefit ratio were significantly better at BFT-C than in either the BFT or control groups.

Conclusion
This study indicates that copepod additions with BFT enhanced prawn postlarvae survival, growth, and whole body protein and lipid, as well as economics, which could augment productivity and sustainability in this industry.
Pacific Lamprey and Western River Lamprey marine ecology: Insight from new ocean collections
Authors: Weitkamp Laurie A. , Tuttle Vanessa , Ward Eric J. , Kamikawa Daniel , Billings Alicia , Buchanan John , Hess Jon E. 
Published: July 2023

Abstract

Objective
Little is known about the marine ecology of anadromous Pacific Lamprey Entosphenus tridentatus and Western River Lamprey Lampetra ayresii. This information is needed to determine how marine life regulates adult abundances and to identify management actions that may benefit declining populations.

Methods
To address this deficit, we compiled historic data, collected lamprey from marine stock assessment surveys and commercial fisheries, and documented fish with Pacific Lamprey wounds.

Result
Pacific Lamprey were most commonly caught by midwater trawls targeting Pacific Hake Merluccius productus along the continental shelf break from northern California to northern Washington. Pacific Lamprey ranged in size from 115 mm total length (TL) and 2.9 g to 714 mm TL and 655 g (n = 1912) and were expected to represent multiple ocean ages. The vast majority (93%) of Pacific Lamprey were small (≤300 mm TL) and thus were likely in their first year in marine waters. Growth for small Pacific Lamprey was estimated as 0.37 mm/day and 0.13 g/day over the summer. Gut fullness for Pacific Lamprey was high (5.5% of body weight [BW]), but it was highly variable for larger individuals (range = 0–55% BW). Our results suggest that there is a positive relationship between calendar day and lamprey length and condition factor in most years, while the effect of latitude varies by life stage. We documented Pacific Lamprey wounds on 240 individual fish representing 16 species, of which six species are newly identified as lamprey hosts. We had comparably few records for Western River Lamprey (n = 72; mean length = 285.5 mm TL), which were primarily found in surface waters on the continental shelf from northern California to southern British Columbia.

Conclusion
Our results have implications for both fisheries and conservation management, including development of best practices for lamprey caught by net fisheries and the use of new marine information to inform conservation actions.
High‐performance epoxy hybrid non‐isocyanate polyurethanes prepared from diol‐cyclocarbonation bisphenol A dicyclocarbonate
Authors: Liu Xiang‐nan , Wang Yuan‐meng , Li Xiang‐yuan , Zhang Jun‐ying , Zhao Jing‐bo 
Published: July 2023

AbstractA new synthesis route different from convenient epoxy/CO2 method was established to synthesize a five‐membered dicyclocarbonate of bisphenol A (BisA‐5dCC), and its hybrid non‐isocyanate polyurethanes with epoxy resins (HNIPUs) were reported. Bisphenol A was first reacted with 3‐chloro‐1,2‐propanediol to prepare a bisphenol A tetraol (BisA‐4OH), and then was reacted with excess diethyl carbonate to obtain BisA‐5dCC. Three polyhydroxyurethanes with H2N‐terminal groups (PHUs) were synthesized from the aminolysis polyaddition of BisA‐5dCC and excess hexanediamine. The PHUs were crosslinked with 1,4‐butanediol diglycidyl ether and bisphenol A diglycidyl ether, respectively, and different HNIPUs were prepared. The structures of BisA‐4OH, BisA‐5dCC, and PHUs were confirmed, and the HNIPUs were characterized by Fourier transform infrared, differential scanning calorimetry, dynamic mechanical analysis, thermogravimetric analysis, and tensile tests. HNIPUs prepared from aromatic epoxy showed higher Tg (up to 81°C) and better tensile strength (as high as 60 MPa) than those from aliphatic epoxy. High‐performance HNIPUs with excellent thermal and mechanical properties were successfully synthesized.Highlights
Dicyclocarbonate of bisphenol A (BisA‐5dCC) was prepared from a BisA tetraol.
H2N‐terminated PHUs were synthesized further from the aminolysis of BisA‐5dCC.
Hybrid non‐isocyanate polyurethanes (HNIPUs) were obtained from PHUs and epoxys.
HNIPUs prepared from aromatic epoxy showed high Tg up to 81°C.
They showed excellent tensile strength as high as 60 MPa.
Examining values in community stories of the electronic platform for adult learning in Europe
Authors: Durnali Mehmet , Ocak Mehmet Akif 
Published: July 2023

AbstractThis research aimed to examine the community stories of the Electronic Platform for Adult Learning in Europe (EPALE) to understand and manage the de facto learning needs of adults in Europe and whether it has the functional capacity to be considered an innovative tool. The EPALE demands high‐quality publication and provides users with six key content types (news, blogs, resources, events, discussions, and community stories) to read, write, and comment on. Specifically, this research delved just into the community stories. We used a qualitative research approach while designing the research in phenomenology. The series of data included adult educators' and learners' stories in the 2020 and 2021 EPALE Community Story Books, and in the EPALE. We employed descriptive and content analysis approaches to find values in the content of the community stories, including the views of 214 users regarding their experiences with adult education. Accordingly, the participants' community tales for 2020 were categorized into four key themes: social inclusion, work skills, basic skills, and culture. The 2021 community stories were categorized into three key themes: inclusive social change, digital transition, and life and work skills. These findings showed the de facto learning themes of adults in Europe. As a result, we understood that community stories and the EPALE are effective adult education tools for gathering and disseminating users' views and experiences to understand diverse learning patterns, which has an influence on the success of adult education implementations.
Preparation of nitro‐phenothiazine‐based oxime esters as dual photo/thermal initiators for 3D printing
Authors: Zhang Xiaoxiang , Peng Xiaotong , Zhu Di , Zhang Yijun , Le Dot Marie , Ozen Serife , Schmitt Michael , Morlet‐Savary Fabrice , Xiao Pu , Dumur Frédéric , Lalevée Jacques 
Published: July 2023

AbstractNowadays, photopolymerization has spanned across all academic and industrial applications due to its appealing features such as energy saving, environmentally‐friendly polymerization conditions, high monomer conversions, rapid polymerization kinetics and so on. Photoinitiator (PI), as a crucial component of the photoinitiating system (PIS) are capable of interacting with light efficiently, enabling to generate initiating species in mono or multicomponent systems. In this work, 13 phenothiazine‐based oxime esters (OXEs) (never reported before) were synthesized and their photoinitiation abilities for the free radical photopolymerization (FRP) of acrylates were examined upon irradiation with LED@405 nm. Parallel to their photochemical reactivities, their abilities to initiate thermal polymerization processes were also investigated. Finally, these OXEs exhibited excellent photo/thermal initiation performances, demonstrating their dual initiation properties. Phenothiazine‐based oxime esters can be used as PIs in 3D printing as well as thermal initiator in the manufacturing of carbon fiber composites.
Black Hole Solutions with Dark Matter Halos in the Four‐Dimensional Einstein‐Gauss‐Bonnet Gravity
Authors: Errehymy Abdelghani , Maurya S. K. , Mustafa G. , Hansraj Sudan , Alrebdi H. I. , Abdel‐Aty Abdel‐Haleem 
Published: July 2023

AbstractBlack holes (BHs) convey information about different matter‐energy distributions in their immediate environment, as they bear the imprints of the intrinsic spacetime geometry and exotic surrounding matter. In this regard, exact spherically symmetric regular black hole (BH) solutions supported by two phenomenological distributions of dark matter galactic halos in Eintein‐Gauss‐Bonnet gravity are explored. Analytical solutions for the metric and the corresponding thermodynamic properties, including heat capacity (), Gibbs' free energy (), and Hawking temperature () associated with the BH's horizon radius and quasinormal modes (QNMs) are found. The specific heat is investigated, and it is discovered that a Hawking‐Page phase transition with divergent occurred at a critical radius, . Consequently, the authors have regular BHs with Cauchy and event horizons, and evaporation results in thermodynamically stable double‐horizon BH remnants with zero temperatures. The QNMs of the scalar field perturbations on the regular background of the BHs are then discussed comprehensively.