bluuebunny/crossref_metadata_2025_split huggingface dataset:
Photochemical Tissue Bonding of Amnion Allograft Membranes for Peripheral Nerve Repair: A Biomechanical Analysis
Authors: King Nicholas C. , McGuire Kalyn R. , Bejar-Chapa Maria , Hoftiezer Yannick A. J. , Randolph Mark A. , Winograd Jonathan M. 
Published: September 2023

Abstract
Background Photochemical tissue bonding (PTB) is a technique for peripheral nerve repair in which a collagenous membrane is bonded around approximated nerve ends. Studies using PTB with cryopreserved human amnion have shown promising results in a rat sciatic nerve transection model including a more rapid and complete return of function, larger axon size, and thicker myelination than suture repair. Commercial collagen membranes, such as dehydrated amnion allograft, are readily available, offer ease of storage, and have no risk of disease transmission or tissue rejection. However, the biomechanical properties of these membranes using PTB are currently unknown in comparison to PTB of cryopreserved human amnion and suture neurorrhaphy.
Methods Rat sciatic nerves (n = 10 per group) were transected and repaired using either suture neurorrhaphy or PTB with one of the following membranes: cryopreserved human amnion, monolayer human amnion allograft (crosslinked and noncrosslinked), trilayer human amnion/chorion allograft (crosslinked and noncrosslinked), or swine submucosa. Repaired nerves were subjected to mechanical testing.
Results During ultimate stress testing, the repair groups that withstood the greatest strain increases were suture neurorrhaphy (69 ± 14%), PTB with crosslinked trilayer amnion (52 ± 10%), and PTB with cryopreserved human amnion (46 ± 20%), although the differences between these groups were not statistically significant. Neurorrhaphy repairs had a maximum load (0.98 ± 0.30 N) significantly greater than all other repair groups except for noncrosslinked trilayer amnion (0.51 ± 0.27 N). During fatigue testing, all samples repaired with suture, or PTBs with either crosslinked or noncrosslinked trilayer amnion were able to withstand strain increases of at least 50%.
Conclusion PTB repairs with commercial noncrosslinked amnion allograft membranes can withstand physiological strain and have comparable performance to repairs with human amnion, which has demonstrated efficacy in vivo. These results indicate the need for further testing of these membranes using in vivo animal model repairs.
The Role of Neuroglobin in the Sleep-Wake Cycle
Authors: García-García Fabio , Acosta-Hernández Mario Eduardo , Beltrán-Parrazal Luis , Rodríguez-Alba Juan Carlos 
Published: September 2023

AbstractNeuroglobin (Ngb) is a protein expressed in the central and peripherical nervous systems of the vertebrate. The Ngb has different functions in neurons, including regulating O2 homeostasis, oxidative stress, and as a neuroprotector after ischemia/hypoxia events. The Ngb is a hemoprotein of the globin family, structurally like myoglobin and hemoglobin. Ngb has higher expression in the cortex, hypothalamus, thalamus, brainstem, and cerebellum in mammals. Interestingly, Ngb immunoreactivity oscillates according to the sleep-wake cycle and decreases after 24 hours of sleep deprivation, suggesting that sleep homeostasis regulates Ngb expression. In addition, Ngb expresses in brain areas related to REM sleep regulation. Therefore, in the present review, we discuss the potential role of the Ngb in the sleep-wake regulation of mammals.
Association Involving Possible Sleep Bruxism, Stress, and Depressive Symptoms in Brazilian University Students: A Cross-sectional Study
Authors: Costa Francine dos Santos , Fernandez Matheus dos Santos , Silva-Junior Ivan Freire da , Karam Sarah Arangurem , Chisini Luiz Alexandre , Goettems Marília Leão 
Published: September 2023

AbstractThe aim of the present study was to examine the association regarding sleep bruxism (SB), depression, and stress in Brazilian university students. We conducted a cross-sectional study with a large-sample of university students (n = 2,089) in the city of Pelotas, Rio Grande do Sul, Southern Brazil. A self-administered questionnaire was sent to classrooms to evaluate socioeconomic and demographic characteristics. Possible SB was detected by self-report according to the International Consensus on The Assessment of Bruxism Criteria (2018). The Patient Health Questionnaire-9 and the Perceived Stress Scale were used to assess depression and stress symptoms respectively. Crude and adjusted Poisson regression analyses were performed. The prevalence of possible SB, high level of stress, and depressive symptoms in the sample were of 20.4%, 16.6%, and 16.6% respectively. Stress in female students was significantly associated with an increased prevalence of possible SB, but not in male students. Regarding depression, the prevalence of SB was 28% higher in students with depressive symptoms. Students with stress or depression had a 35% higher prevalence of SB than those without any symptoms.
Conclusion The findings have shown that university students with stress and depressive symptoms were more likely to be detected with possible SB.
Obstructive Sleep Apnea Treatment with Oral Appliance in a Myotonic Dystrophy Type I Subject: A Case Report
Authors: Guimarães Maria de Lourdes Rabelo , Ribeiro Milena Carvalho Tourino , Barbosa Thiago Antunes da Silva , Costa Laila Gabriela de Figueiredo , Bastos Patricia Souza 
Published: September 2023

Abstract
Objective to report a myotonic dystrophy type 1 (MD1) subject with obstructive sleep apnea syndrome treated with oral appliance.
Methods A review of individual's history and records, associated with a photographic register of all diagnostic methods and literature research about the topic were done.
Final Statements This case depicts the therapeutical choices disposable to treat subjects with obstructive sleep apnea and DM1. Although considered an uncommon treatment, the oral appliances, if well indicated in adequately selected cases, can satisfactorily improve respiratory parameters, symptoms and quality of life.
Impact on Neonatal Outcomes with Late Preterm and Early Term Delivery in Women with Diabetes
Authors: Austin Brittany A. , McFarling Kelli M. , Likins Benjamin , Chapman Alison , Cuff Ryan D. , Head Barbara , Finneran Matthew M. 
Published: September 2023

Objective Late preterm and early term deliveries are common in pregnancies complicated by diabetes due to higher rates of obstetric complications including increased stillbirth risk. However, early delivery is associated with multiple neonatal adverse outcomes, which may be further increased by maternal diabetes. We examined whether there is an additive effect on adverse neonatal outcomes in the setting of maternal diabetes in the late preterm and early term periods.
Study Design This was a retrospective cohort study of women with a singleton, nonanomalous pregnancy delivering at a single academic medical center in the late preterm (340/7–366/7 weeks) or early term (370/7–386/7 weeks) period between 2010 and 2019. Women were categorized by diabetes status: no diabetes, type 1 (T1DM), type 2 (T2DM), or gestational diabetes (GDM). Multivariate logistic regression was used to calculate adjusted odds ratios (aOR) and 95% confidence intervals (CI) for risk of both mild and severe composite neonatal outcome with delivery in the late preterm or early term period using pregnancies without diabetes as the referent.
Results A total of 8,072 pregnancies were included with T1DM, T2DM, and GDM complicating 1.8, 5.6, and 9.9% of pregnancies, respectively. Expected demographic differences were seen among groups including higher rates of non-Hispanic Black race, chronic hypertension, and higher body mass index in women with T2DM. The probability of severe composite adverse neonatal outcome was significantly increased in women with T1DM in the late preterm (aOR: 4.4; CI: 2.4–8.1) and early term (aOR: 1.6; CI: 1.1–2.3) periods, largely driven by the need for mechanical ventilation. The mild composite outcome was increased among all women with diabetes with early term delivery but highest in women with T1DM.
Conclusion Pregnancies complicated by diabetes, particularly T1DM, have higher rates of neonatal adverse outcomes independent of gestational age at delivery, which is an important consideration when late preterm or early term delivery is planned.
Key Points
Surgical and Interventional Radiology Management of Vascular and Biliary Complications in Liver Transplantation: Narrative Review
Authors: Barragan Camilo , Vera Alonso , Hoyos Sergio , Bejarano Diana , Lopez-Ruiz Ana Maria , Grippi Francisco , Mejia Alejandro , Bayona Molano María del Pilar 
Published: September 2023

AbstractLiver transplant patients require a multidisciplinary and personalized approach to optimize outcomes. Posttransplant complications can be devastating for the patient and can jeopardize graft survival. Therefore, a careful evaluation and stepwise decision-making process is necessary to determine the best strategy, whether it is surgical, interventional, or a combination of both. While access to liver transplant interventions in Latin America can be more limited compared with other parts of the world, many countries in the region have made significant progress in developing their liver transplant programs and improving the management of posttransplant complications. For example, in Brazil, specialized transplant centers and multidisciplinary teams have been established to reduce morbidity and improve graft survival rates. The article also explores the latest advancements in interventional radiology techniques, such as angioplasty, stent placement, and embolization, and how they can be used to successfully treat these complications. Overall, this article highlights the importance of a comprehensive approach to managing complications in liver transplant patients and emphasizes how individualized treatment plans can lead to improved outcomes, even in settings with limited resources.
The Transition to Ophthalmology Residency: A National Survey of the Combined Ophthalmology PGY-1 Program
Authors: Azad Amee D. , Yuan Melissa , Weinert Marguerite , Rosenblatt Tatiana R. , Miller Joan W. , Lorch Alice 
Published: September 2023

Abstract
Background In 2017, the Accreditation Council for Graduate Medical Education announced all ophthalmology residency programs would provide a combined transitional or joint preliminary program for first postgraduate year (PGY-1) residents, with mandatory implementation by 2023.
Purpose This study aimed to survey ophthalmology residency program directors, postgraduate year 2 (PGY-2) ophthalmology residents who were a part of the first, official combined ophthalmology PGY-1 year, and postgraduate year 3 (PGY-3) residents who were a PGY-1 resident the year prior to integration to evaluate characteristics and perspectives on the combined ophthalmology PGY-1 year.
Methods A national, internet survey-based study approved by the Association of University Professors of Ophthalmology (AUPO) was disseminated to the AUPO listserv of program directors (PDs) and PGY-2 and PGY-3 ophthalmology residents from July to August 2022 and then again April to June 2023.
Results Twenty-six PDs completed the survey (response rate 20.3% out of 128 PDs). Forty-one PGY-2 ophthalmology residents who underwent the combined ophthalmology PGY-1 year and 33 PGY-3 ophthalmology residents also completed the survey. Most PGY-1 curricula focused on exposure to comprehensive ophthalmology and provided indirect ophthalmoscope, slit lamp, and refraction skills training to residents. Early exposure to fundamentals and clinical workflows were commonly cited benefits to the integration. When PDs were surveyed about how well-prepared PGY-1 residents who went through the combined year are for the PGY-2 relative to the prior year's class, 16 (61.5%) responded “better prepared.” PGY-2 residents also reported a relatively higher level of clinical preparedness and familiarity with ophthalmology co-residents than PGY-3 residents. Several areas of improvement cited by both PDs and residents were identified including a dedicated didactic curriculum and more time in ophthalmology during the PGY-1 year.
Conclusions We found an overall net benefit from the integration of the combined ophthalmology PGY-1 year. Benefits include early exposure to clinical skills and knowledge specific to ophthalmology, leading to increased confidence and preparedness for the rigorous transition to ophthalmology residency. We also identified many areas for improvement to optimize the PGY-1 year including a formal curriculum and additional time in ophthalmology. Programs should work closely with their residents, faculty, and non-ophthalmology PDs to refine the PGY-1 for the benefit of future ophthalmologists.
Improved Performance of ChatGPT-4 on the OKAP Examination: A Comparative Study with ChatGPT-3.5
Authors: Teebagy Sean , Colwell Lauren , Wood Emma , Yaghy Antonio , Faustina Misha 
Published: September 2023

Abstract
Introduction: This study aims to evaluate the performance of ChatGPT-4, an advanced artificial intelligence (AI) language model, on the Ophthalmology Knowledge Assessment Program (OKAP) examination compared to its predecessor, ChatGPT-3.5.
Methods: Both models were tested on 180 OKAP practice questions covering various ophthalmology subject categories.
Results: ChatGPT-4 significantly outperformed ChatGPT-3.5 (81% vs. 57%; p<0.001), indicating improvements in medical knowledge assessment.
Discussion: The superior performance of ChatGPT-4 suggests potential applicability in ophthalmologic education and clinical decision support systems. Future research should focus on refining AI models, ensuring a balanced representation of fundamental and specialized knowledge, and determining the optimal method of integrating AI into medical education and practice.
Trust across borders: a review of the research on interorganizational trust in international business
Authors: Zou Tengjian , Ertug Gokhan , Cuypers Ilya R. P. , Ferrin Donald L. 
Published: September 2023

AbstractTrust between organizations has been recognized as crucial in international business (IB) and has attracted extensive research attention. Researchers have conceptualized and measured interorganizational trust in multiple ways, investigated numerous determinants and outcomes of interorganizational trust, and explored interorganizational trust in several types of international relationships across a range of country combinations using varied research methodologies. Our review aims to consolidate and advance this literature by focusing on (i) how interorganizational trust has been conceptualized in IB; (ii) how interorganizational trust has been operationalized in IB; (iii) what factors promote or hinder interorganizational trust in IB; (iv) what the outcomes are of interorganizational trust in IB; and (v) how interorganizational trust has been studied in IB. For each question, we analyze the literature and then provide recommendations and directions for future research. We aim to provide a solid grounding for future research that will keep this area theoretically sound, empirically robust, and phenomenologically relevant.
Radiation tolerance and self-healing in triple halide perovskite solar cells
Authors: Afshari Hadi , Chacon Sergio A. , Sourabh Shashi , Byers Todd A. , Whiteside Vincent R. , Crawford Rose , Rout Bibhudutta , Eperon Giles E. , Sellers Ian R. 
Published: September 2023

The high tolerance and stability of triple halide perovskite solar cells is demonstrated in practical space conditions at high irradiation levels. The solar cells were irradiated for a range of proton energies (75 keV, 300 keV, and 1 MeV) and fluences (up to 4 × 1014 p/cm2). The fluences of the energy proton irradiations were varied to induce the same amount of vacancies in the absorber layer due to non-ionizing nuclear energy loss (predominant at &lt;300 keV) and electron ionization loss (predominant at &gt;300 keV). While proton irradiation of the solar cells initially resulted in degradation of the photovoltaic parameters, self-healing was observed after two months where the performance of the devices was shown to return to their pristine operation levels. Their ability to recover upon radiation exposure supports the practical potential of perovskite solar cells for next-generation space missions.
Development and testing of secondary ion accelerator for ITER neutral particle diagnostic system
Authors: Afanasyev V. I. , Chernyshev F. V. , Kozlovsky S. S. , Melnik A. D. , Mironov M. I. , Mokeev A. N. , Navolotsky A. S. , Nesenevich V. G. , Petrov M. P. , Petrov S. Ya 
Published: September 2023

This paper presents the results of the development and testing of a secondary ion accelerator for the diagnostic complex of neutral particle analyzers at ITER. The accelerator is part of an analyzer designed to measure fluxes of neutral deuterium and tritium particles escaping from reactor plasma in a total range of 10–200 keV. The aim of the accelerator is to improve the signal/background ratio of the analyzer. It is especially important for the region with a relatively low energy of 10–50 keV. The accelerator has the function of converting atoms into secondary ions and accelerating them in an electrostatic field with a voltage of up to +100 kV. The accelerator is based on two high-voltage accelerating tubes. A special unit is built into the central electrode of the accelerator, which provides the replacement of stripping foils used for the conversion of the flux of neutral particles into a flux of secondary ions. The high-voltage tube assembly is encompassed by a sealed steel housing, in which electrical insulation is provided by a gas gap (nitrogen at 6 bar). The results of tests of the accelerator under ITER relevant conditions, namely, under high-intensity gamma irradiation and seismic loads, have shown its high reliability for use in the diagnostic complex of the fusion reactor.
A high-bandwidth voltage amplifier for driving piezoelectric actuators in high-speed atomic force microscopy
Authors: Andany Santiago H. , Nievergelt Adrian P. , Kangül Mustafa , Ziegler Dominik , Fantner Georg E. 
Published: September 2023

High-speed atomic force microscopy (HS-AFM) is a technique capable of revealing the dynamics of biomolecules and living organisms at the nanoscale with a remarkable temporal resolution. The phase delay in the feedback loop dictates the achievable speed of HS-AFM instruments that rely on fast nanopositioners operated predominantly in conjunction with piezoelectric actuators (PEAs). The high capacitance and high operating voltage of PEAs make them difficult to drive. The limited bandwidth of associated high-voltage piezo-amplifiers is one of the bottlenecks to higher scan speeds. In this study, we report a high-voltage, wideband voltage amplifier comprised of a separate amplification and novel voltage-follower power stage, requiring no global feedback. The reported amplifier can deliver a current over ±2 amps, offers a small-signal bandwidth of 1 MHz, and exhibits an exceptionally low phase lag, making it particularly well suited for the needs of next-generation HS-AFMs. We demonstrate its capabilities by reporting its achievable bandwidth under various PEA loads and showcasing its merit for HS-AFM by imaging tubulin protofilament dynamics at sub-second frame rates.
Polyzwitterion fast and slow mode behavior are coupled to phase separation as observed by dynamic laser light scattering
Authors: Pickett Phillip D. , Ma Yuanchi , Prabhu Vivek M. 
Published: September 2023

A model zwitterionic polysulfobetaine, poly(3-(acrylamidopropyl-dimethyl-ammonium) propyl-1-sulfonate) (pAPAPS), phase separates upon cooling and exhibits an upper critical solution temperature (UCST) behavior with no added salt in deuterium oxide solutions. Dynamic light scattering measurements indicate the presence of distinct fast and slow diffusive modes, where the fast mode is interpreted as a collective diffusion coefficient and the slow mode is attributed to the diffusion of multi-chain dynamic clusters. The relative population of fast and slow modes varies systematically with temperature and concentration. A clustering temperature (T*) was assigned when the slow mode first appeared upon cooling. The slow mode then increases in relative scattering amplitude as the phase boundary is approached. The fast mode exhibits a concentration dependence above T* consistent with the virial expansion in the collective diffusion. The sign of the virial coefficient (kd) is negative, even in the good solvent region above the expected Flory temperature (Θ ≈ 39 °C), a behavior distinct from synthetic neutral polymers in organic solvents. The onset of multi-chain clustering at T &lt; T* coincides with the poor solvent regime (T &lt; Θ). Attractive dipolar interactions due to the zwitterionic sulfobetaine groups in pAPAPS are suggested as the origin of the multi-chain clusters with no salt. Upon the addition of 100 mM NaCl, the slow mode is suppressed, and the hydrodynamic radius is consistent with polyzwitterion chain dimensions in a dilute solution. We find that concentration dependent diffusion is highly linked to the theta temperature and the emergence of dynamic clusters as the polymer goes from good to poor solvent on approach to the UCST. The slow mode in the semidilute regime is reported along with preliminary small-angle neutron scattering data that show salt reduces clustering and leads to predominantly chain scattering.
Assessing lead curtains’ impact on radiation protection in coronary interventions
Authors: Zhiting Wang , Xiang Zheng , Chang Yu , Yinuo Lin , Fang Lin , Xiao Chen 
Published: September 2023

Abstract
The objective of this investigation is to assess the impact of supplementary lead curtains on the reduction of radiation dose exposure to operators during coronary interventional procedures. Seven standard positions during coronary angiography (foot, right foot, head, left foot, left lateral, left head, and right lateral) were simulated on a standard anthropomorphic phantom with radial artery access. Measurements were taken at two different heights, 125 cm and 155 cm, and dosimeters were used to measured surface incident dose rates for the first and second operators, both with and without additional lead curtains at various positions. Each position was measured 20 times, and arithmetic means were computed. A t-test was utilised to compare dose rates with and without supplementary lead curtains, as well as dose rates with additional lead curtains at varying heights. The finding indicate that the dose rates of the first operator with supplementary lead curtains were not significantly lower compared to those without, except for the 125 cm head and left foot positions and the 155 cm head position with the additional lead curtain edge 10 cm below the umbilical level (t
umbilical = 0.9, 0.4, 0.5, P > 0.05). The dose rates of the second operator with additional lead curtains were significantly lower than those without, with statistically significant differences (P < 0.05). The arithmetic mean dose rates for the first and second operators at each position were lowest when the upper edge of the additional lead curtain was situated 10 cm above the umbilical level. Employing supplementary lead curtains during coronary interventions effectively reduces radiation doses received by operators. The protective effect is enhanced when the additional lead curtain is closer to the irradiation field. Hence, it is recommended that additional curtains be employed judiciously, while ensuring that clinical procedures are not impeded, in order to effectively mitigate the radiation exposure of operators.