bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vapor-Deposited Polymer Films and Structure: Methods and Applications
Authors: Chou Fang-Yu , Ramli Theresia Cecylia , Lee Chin-Yun , Hu Shu-Man , Christy Jane , Chen Hsien-Yeh 
Published: April 2023

Vapor deposition of polymers is known to result in densified thin films, and recent developments have advanced these polymers with interesting fabrication techniques to a variety of controlled structures other than thin films. With the advantages of chemical modification and functionalization of these polymers, advancements have combined both the physical and chemical properties of these vapor-deposited polymers to obtain controlled anisotropic polymers, including layer-by-layer, gradient, hierarchical, porosity, and the combination of the above, meaning that the produced polymers are functional and are addressed in devised physical configurations and chemical compositions. The main purpose of using polymer coatings as a tool for surface modification is to provide additional properties that decouple the natural properties of the underlying materials (including metals, polymers, oxides/ceramics, glass, silicon, etc.), and recent advancements have rendered novel insights into combined physical and chemical properties to fulfill the increasing needs of sophisticated requirements of materials for users. The review herein intends to deliver messages of recent progress of the advancements of vapor-deposited polymers, with discussions of the variations of the physical structures and chemical functionalities, and how these two aspects are integrated with novel fabrication techniques. The advanced vapor polymers now have the capability of controlled anisotropy in the physical structure and chemical composition and are expected to pave the way for interface engineering toward prospective material designs.Table of content:1. Introduction2. Fabrication and Materials3. Controls of Anisotropy4. Applications5. Conclusions and Outlook
Biocatalytic Synthesis of Chiral Benzylic Alcohols via Enantioselective Hydroxylation by a Self-Sufficient Cytochrome P450 from Deinococcus gobiensis
Authors: Chen Yong-Zheng , Cui Hai-Bo , Ma Ting , Zhang Ru-Yue , Shan Jing , Wang Zhong-Qiang , Bai Mei 
Published: April 2023

AbstractEnzymatic asymmetric benzylic hydroxylation represents a green synthesis of valuable chiral benzylic alcohols. The stereoselective C–H direct hydroxylation profile possessed by cytochrome P450 monooxygenases (P450s) makes it more attractive. Here, we successfully expressed a self-sufficient cytochrome P450 monooxygenase from Deinococcus gobiensis in Escherichia coli BL21(DE3) host. The recombinant E. coli (P450DG) strain performed well in terms of functionality and has stereoselective benzylic hydroxylation ability for propylbenzene substrates. Asymmetric benzylic hydroxylation of various aromatic compounds was further investigated using the recombinant E. coli (P450DG) strain based on the optimal conditions, producing the corresponding enantioenriched pharmaceutically relevant benzylic alcohols in moderate yields with good to excellent enantioselectivity.
Efficacy of Antiseizure Medications in Wolf–Hirschhorn Syndrome
Authors: Horiguchi Ayumi , Koichihara Reiko , Kikuchi Kenjiro , Nonoyama Hazuki , Daida Atsuro , Oba Daiju , Hirata Yuko , Matsuura Ryuki , Ohashi Hirofumi , Hamano Shin-ichiro 
Published: April 2023

AbstractWolf–Hirschhorn syndrome (WHS) is caused by deletion of the terminal region of chromosome 4 short arm and is frequently associated with intractable epilepsy. This article evaluates the clinical features of epileptic seizures in WHS and the therapeutic efficacy of oral antiseizure medications (ASMs). Patients with WHS who were treated for epilepsy at the Saitama Children's Medical Center under 5 years of age were included. WHS was diagnosed based on genetic tests and clinical symptoms. Medical records regarding the age of onset of epilepsy, seizure type, treatment of status epilepticus (SE), and effectiveness of ASMs were retrospectively reviewed. Oral ASMs were considered effective when seizures were reduced by at least 50% compared with the premedication level. Eleven patients were included in the study. The median age at the onset of epilepsy was 9 months (range: 5–32 months). Unknown-onset bilateral tonic-clonic seizure was the most common type of seizure, occurring in 10 patients. Focal clonic seizures occurred in four patients. Ten patients exhibited recurrent episodes of SE, and its frequency during infancy was monthly in eight patients and yearly in two. SE occurrence peaked at 1 year of age and decreased after 3 years of age. The most effective ASM was levetiracetam. Although WHS-associated epilepsy is intractable with frequent SE occurrence during infancy, improvement in seizure control is expected with age. Levetiracetam may be a novel ASM for WHS.
A Straightforward Synthesis of Emericellamide A Using Matteson’s Homologation Approach
Authors: Kazmaier Uli , Priester Ronja 
Published: April 2023

AbstractThe Matteson homologation is the perfect approach for the synthesis of polyketide–peptide natural products such as the emericellamides. In only four steps, the polyketide fragment with three stereogenic centers can be obtained as a single stereoisomer. The peptide fragment is easily available via solid-phase peptide synthesis.
Synthesis of Highly Substituted 3-Acylpyrroles by a Four-Component Sonogashira Alkynylation–Amine Addition–Nitroalkene Michael Addition–Cyclocondensation
Authors: Müller Thomas J. J. , Schmitz G. Hendrik , Lampiri Panagiota 
Published: April 2023

AbstractA consecutive four-component alkynylation–amine addition–nitroalkene addition–cyclocondensation one-pot reaction of acid chlorides, alkynes, amines, and nitroalkenes furnished a library of 3-acylpyrroles in modest to good yields. The sequence takes advantage of a synergism between a Brønsted acid (acetic acid) and a Lewis acid [iron(III) chloride] in the terminal addition-cyclocondensation step of the intermediately formed enaminones with nitroalkenes.
Meek Micrografting Technique for Reconstruction of Extensive Necrotizing Fasciitis of the Anterior Abdomen and Bilateral Femoral Region: A Case Report
Authors: Ng Jyi Cheng , Ahmad Zaidi Ahmad Ibrahim , Lee Jun De , Jabar Mohd Faisal 
Published: April 2023

AbstractNecrotizing fasciitis is an uncommon yet fatal soft tissue infection. Current recommended treatment includes antibiotics with repeat surgical exploration and wound debridement followed by reconstruction. In burn patients, the Meek micrograft has demonstrated a higher true expansion ratio, faster reepithelialization rate, more resilient toward infection, and reduced risk of graft failure as compared with meshed graft. To our best knowledge, the use of Meek micrografting technique in reconstruction of postdebridement wounds of necrotizing fasciitis has not been reported. Hereby, we present a case of a 57-year-old gentleman who was referred to us for wound reconstruction after surgical debridement of Fournier's gangrene and extensive necrotizing fasciitis involving the anterior abdomen and bilateral femoral region. Meek micrografting technique was used to reconstruct the anterior abdomen as the wound bed was large. Although the graft was complicated with a small area of localized infection, it did not spread across the entire graft and was successfully treated with topical antibiotics and regular wound dressing. In our case, wound reconstruction using Meek micrografting technique in a patient with extensive necrotizing fasciitis was successful and showed positive outcome. Therefore, we suggest further studies to be conducted to investigate the applications and outcomes of the Meek micrografting technique, especially in patients with extensive wound bed and limited donor site availability.
Actigraphy-Based Sleep Parameters in Wheelchair Basketball Athletes: Influence of Training and Competition Load
Authors: López-Flores Marcos , Suárez-Iglesias David , Rodríguez-Marroyo José Antonio 
Published: April 2023

Abstract
Objective This study aimed to analyze the actigraphy-based sleep parameters in wheelchair basketball (WB) athletes during the 3 weeks leading up to the playoffs, the week of playoffs, and the week after playoffs. Secondarily, the relationship between training load, sleep, and recovery was evaluated.
Methods During 5 consecutive weeks, 10 male elite WB athletes wore a triaxial accelerometer. The session rating of perceived exertion (sRPE) and athletes' quality of recovery were also measured.
Results There were no significant differences (p > 0.05) in any of the studied parameters between the 3 weeks leading up to the playoffs, the week of playoffs, and the week after playoffs. No significant relationship between training load, sleep parameters, and recovery values was detected.
Discussion The WB competition does not affect sleep quantity and quality.
Altitude and Breathing during Sleep in Healthy Persons and Sleep Disordered Patients: A Systematic Review
Authors: Rojas-Córdova Stephanie , Torres-Fraga Martha Guadalupe , Rodríguez-Reyes Yadira Guadalupe , Guerrero-Zúñiga Selene , Vázquez-García Juan Carlos , Carrillo-Alduenda José Luis 
Published: April 2023

Abstract
Objetive The aim of this systematic review is to analyze the recent scientific evidence of the clinical effects of altitude on breathing during sleep in healthy persons and sleep disordered patients.
Material and Methods A search was carried out in PubMed and Scopus looking for articles published between January 1, 2010 and December 31, 2021, in English and Spanish, with the following search terms: “sleep disorders breathing and altitude”. Investigations in adults and carried out at an altitude of 2000 meters above mean sea level (MAMSL) or higher were included. The correlation between altitude, apnea hypopnea index (AHI) and mean SpO2 during sleep was calculated.
Results 18 articles of the 112 identified were included. A good correlation was found between altitude and AHI (Rs = 0.66 P = 0.001), at the expense of an increase in the central apnea index. Altitude is inversely proportional to oxygenation during sleep (Rs = −0.93 P = 0.001), and an increase in the desaturation index was observed (3% and 4%). On the treatment of respiratory disorders of sleeping at altitude, oxygen is better than servoventilation to correct oxygenation during sleep in healthy subjects and acetazolamide controlled respiratory events and oxygenation during sleep in patients with obstructive sleep apnea under treatment with CPAP.
Conclusions Altitude increases AHI and decreases oxygenation during sleep; oxygen and acetazolamide could be an effective treatment for sleep-disordered breathing at altitude above 2000 MAMSL.
Immediate and Medium-Term Follow-Up of Patients with Obstructive Sleep Apnea Undergoing Pharyngeal and Nasal Surgery: A Pilot Study
Authors: Stefanini Renato , Campanholo Milena de Almeida Torres , Prescinotto Renato , Caparroz Fábio de Azevedo , Bittencourt Lia Rita Azeredo , Tufik Sergio , Haddad Fernanda Louise Martinho 
Published: April 2023

Abstract
Objectives To evaluate the evolution of obstructive sleep apnea (OSA), comparing data from preoperative, immediate postoperative and late postoperative, in patients undergoing pharyngeal surgery associated with nasal surgery, and to compare the findings of arterial tonometry and type 1 polysomnography in the late postoperative period.
Methods Seventeen adults with moderate or severe OSA were included in the study. They underwent clinical evaluation, surgical intervention, and sleep study preoperatively, on the 1st night after surgery, and after a minimum period of 3 months. The data for the three moments were compared.
Results The mean age was 38.1 ± 12.5 years old (22 to 59 years old), and 82.3% were male. Body mass index (BMI) ranged from 25.6 to 45.1 kg/m2 (mean = 33.1 ± 5.8 kg/m2). Fifteen patients (88.2%) were diagnosed with severe OSA. There was a progressive improvement, with a decrease in the indexes (AHI and RDI) and in the percentage of time with peripheral oxyhemoglobin saturation below 90% (tSpO < 90%), and an increase in nadir of SpO2. In the comparison between the 2 methods used in the late postoperative period – arterial tonometry and polysomnography – there was no difference in the indexes and in the tSpO < 90%.
Discussion There was a progressive and favorable impact of pharyngeal surgery on the improvement of polysomnographic and clinical respiratory parameters; however, many patients maintained residual OSA, suggesting the need for a new sleep study in the postoperative period. The arterial tonometry showed similar findings to polysomnography, which can be considered as an option in postoperative follow-up of patients.
Is Being a Lark Healthier for Patients with Type 1 Diabetes Mellitus?
Authors: Valiensi Stella Maris , Folgueira Agustín Leandro , Diez Joaquin Jose , Gonzalez-Cardozo Agustin , Vera Vanesa Antonella , Camji Julieta Marina , Alvarez Adriana Mabel 
Published: April 2023

Abstract
Background Sleep quality and mood have been evaluated in type 1 diabetic (T1DM) patients, but chronotypes were not studied. Our objectives were to analyze chronotypes, sleep and mood variables and to describe their association with some metabolic variables in this population.
Methods An observational, cross-sectional study was performed. Adults with a diagnosis of T1DM were included. We evaluated chronotypes by the Morningness-Eveningness Questionnaires, sleep quality by Pittsburgh Sleep Quality Index (PSQI), excessive daytime sleepiness by Epworth Sleepiness Scale (ESS), symptoms of depression by Patient Health Questionnaire - 9 (PHQ-9) and emotional well-being by Emotional Well Being Index (IWHO-5). A few metabolic variables were included.
Results Ninety-five patients participated. The mean age was 38 years old (range 18–70). The average body mass index (BMI) was 24.4 Kg/m2 (standard deviation [SD]: 4.6). Out of the total sample, 52.6% were males. The Intermediate chronotype was predominant: n = 56 (55%). We found poor quality of sleep in 67.4% of the sample, excessive daytime sleepiness in 14.7%, depressive symptoms in 6.3% by PHQ9 and low perception of well-being by IWHO-5 in 16.8%. Evening chronotype scored worse in sleep quality (p = 0.05) and had lower well-being (p = 0.03) compared with the other chronotypes. Higher MEQ values (morningness) correlated with lower height (p = 0.043), lower values in the PSQI (p = 0.021); and higher values in emotional well-being (p = 0.040).
Conclusions We found that the predominant chronotype in T1DM was the intermediate. Two-thirds reported poor quality of sleep and 14,7% excessive daytime sleepiness. Possible diagnosis of a depressive disorder in 6.3% and poor self-perception of emotional well-being in 16. 8% were observed. The morning chronotype had significant correlation with better sleep quality and higher scores in emotional well-being.
Insomnia Severity is Associated with Morning Cortisol and Psychological Health
Authors: Passos Giselle Soares , Youngstedt Shawn D. , Rozales Ariella Ariella Rodrigues Cordeiro , Ferreira Walkyria Silva , De-Assis Daniela Elias , De-Assis Bernardo Pessoa , Santana Marcos Gonçalves 
Published: April 2023

AbstractStudies suggest associations between cortisol and sleep, and cortisol shows a profound diurnal rhythm. The evidence about the relationship between chronic insomnia and cortisol is mixed. Chronic insomnia is associated with the risk of mental health disorders. The aim of this study was to evaluate the association of insomnia severity and objective sleep pattern with morning cortisol level and psychological health. The instruments used were the Insomnia Severity Index (ISI), polysomnography, Beck Depression Inventory (BDI), and Profile of Mood States (POMS). Serum cortisol was analyzed by chemiluminescence. The data revealed significant positive correlations of ISI with morning cortisol level (r = 0.37, p = 0.03), BDI score (r = 0.44, p < 0.01), and POMS-tension anxiety (r = 0.39, p = 0.02). Sleep stages N2 and N3 were correlated with POMS-fatigue (r = 0.46, p < 0.01; r = -0.37, p = 0.04). Sleep stage N3 was also negatively correlated with POMS-tension-anxiety (r = -0.36, p = 0.04). Higher insomnia severity was associated with higher morning cortisol, depression, and tension-anxiety. Sleep stage N2 was associated with higher fatigue and N3 was associated with lower tension-anxiety and fatigue.
Assessment of the Anterior Clinoid Process and Optic Strut in Chiari Malformation Type I: A Computed Tomography Study
Authors: Özalp Hakan , Özgüral Onur , Alpergin Baran C. , İnceoğlu Ayşenur , Özalp Sibel , Armağan Ercan , Uçar Hadice , Beger Orhan 
Published: April 2023

Abstract
Objective This study aimed to evaluate morphological features of the anterior clinoid process (ACP) and the optic strut (OS) in Chiari malformation Type I (CM-I).
Methods The study universe consisted of computed tomography images of 41 CM-I patients and 45 normal subjects. Comparison of the parameters for CM-I and the control group was performed with the Student's t-test. A “p < 0.05” was accepted as the significance level.
Results ACP length was smaller in CM-I than the control group (p < 0.001). In contrast to ACP length, ACP angle (p < 0.001), OS length (p = 0.022), and the distance between ACP and OS (p = 0.020) were found greater in CM-I in comparison to the control group (p < 0.05). ACP width (p = 0.233) and OS width (p = 0.376) were similar in both groups. ACP pneumatization in CM-I group was found as 12.20%, whereas in the control group as 8.90%. Two different types about the pneumatization were identified in CM-I group (Type 1: 4.9% and Type 2: 7.3%), whereas three different types in the control group (Type 1: 3.3%, Type 2: 4.4%, and Type 3: 1.1%). Relative to ACP, three different types about OS position were identified in CM-I group (Type C: 31.70%, Type D: 64.60%, and Type E: 3.70%) and the control group (Type C: 7.80%, Type D: 64.40%, and Type E: 27.80%).
Conclusion Shorter ACP, wide-angled ACP, longer OS, and more anteriorly located OS were found in CM-I group compared with the normal group. Our findings showed that the pneumatization of ACP was not affected by CM-I.
Voice assistants in private households: a conceptual framework for future research in an interdisciplinary field
Authors: Minder Bettina , Wolf Patricia , Baldauf Matthias , Verma Surabhi 
Published: April 2023

AbstractThe present study identifies, organizes, and structures the available scientific knowledge on the recent use and the prospects of Voice Assistants (VA) in private households. The systematic review of the 207 articles from the Computer, Social, and Business and Management research domains combines bibliometric with qualitative content analysis. The study contributes to earlier research by consolidating the as yet dispersed insights from scholarly research, and by conceptualizing linkages between research domains around common themes. We find that, despite advances in the technological development of VA, research largely lacks cross-fertilization between findings from the Social and Business and Management Sciences. This is needed for developing and monetizing meaningful VA use cases and solutions that match the needs of private households. Few articles show that future research is well-advised to make interdisciplinary efforts to create a common understanding from complementary findings—e.g., what necessary social, legal, functional, and technological extensions could integrate social, behavioral, and business aspects with technological development. We identify future VA-based business opportunities and propose integrated future research avenues for aligning the different disciplines’ scholarly efforts.
Generational effects of culture and digital media in former Soviet Republics
Authors: Horne Benjamin D. , Rice Natalie M. , Luther Catherine A. , Ruck Damian J. , Borycz Joshua , Allard Suzie L. , Fitzgerald Michael , Manaev Oleg , Prins Brandon C. , Taylor Maureen , Bentley R. Alexander 
Published: April 2023

AbstractIn public opinion, social and digital media provide means for influence as well as sorting according to pre-existing values. Here we consider types of media usage versus opinion using new polling results in the former Soviet republics (FSRs) of Belarus, Ukraine, and Georgia. Over 1000 individuals in each country were asked about a news event (the January 6 riot at the U.S. Capitol) and about the long-term future of their country. We find that year of birth and country of residence, rather than self-reported media reliance, consistently predicted the respondents’ views, particularly on the future of their country. The timing of these differences suggests a cultural difference between generations growing up in the Soviet Union (likely more pro-Russian) versus afterward, in an FSR (more pro-Western). Whereas digital media choice is somewhat correlated with perceptions of a recent, international news event, the more predictive factors are longer-term cultural values and age cohorts within each nation.
Overexpression of ClRAP2.4 in Chrysanthemum enhances tolerance to cold stress
Authors: Ren Manrong , Yang Wenting , Zhang Jianing , Zhao Li , Quan Yingjie , He Zihan , Xu Yanan , Zhang Fageng , Yin Ming , Wang Yaoying , Gao Ri 
Published: April 2023

The apetala/ethylene responsive factor (AP2/ERF) family is one of the largest plant-specific transcription factors and plays a vital role in plant development and response to stress. The apetala 2.4 (RAP2.4) gene is a member of the AP2/ERF family. In this study, ClRAP2.4 cDNA fragment with 768 bp open reading frame was cloned and the resistance of ClRAP2.4 overexpression to low temperature was investigated to understand whether RAP2.4 is involved in low-temperature stress in chrysanthemum (Chrysamthemum lavandulifolium). Phylogenetic analysis showed that ClRAP2.4 belonged to the DREB subfamily and was most closely related to AT1G22190. ClRAP2.4 was localised in cell nucleus and promotes transcriptional activation in yeast. In addition, ClRAP2.4 was transformed by using the Agrobacterium-mediated leaf disc method, and four overexpression lines (OX-1, OX-2, OX-7, and OX-8) were obtained. The activities of superoxide dismutase and peroxidase, and proline content in leaves in the four overexpression line were higher than those in the wild type (WT), whereas the electrical conductivity and malondialdehyde content were decreased, indicating that the tolerance of plants with ClRAP2.4 overexpression to cold stress was increased. RNA-Seq showed 390 differentially expressed genes (DEGs) between the transgenic and WT plants(229 upregulated, 161 downregulated). The number of ABRE, LTR, and DRE cis-elements in the promoters of DEGs were 175, 106, and 46, respectively. The relative expression levels of ClCOR, ClFe/MnSOD, ClPOD, ClNCL, ClPLK, ClFAD, and ClPRP in the transgenic plants were higher than those in WT plants at low temperatures. These data suggest that ClRAP2.4 may increase chrysanthemum tolerance to cold stress.