bluuebunny/crossref_metadata_2025_split huggingface dataset:
Management of traumatic dental injuries: a survey of paediatric emergency department health professionals
Authors: Gallichan Nathalie , Albadri Sondos , Watkins Francine , Jarad Fadi , Messahel Shrouk , Hartshorn Stuart , Gartshore Laura 
Published: March 2023

ObjectiveTo assess paediatric emergency department (PED) health professionals’ confidence, experience and awareness in managing traumatic dental injuries (TDIs).DesignA cross-sectional online survey.SettingPED at Alder Hey Children’s Hospital and Birmingham Children’s Hospital.Results94 ED health professionals responded. One-third of responders (n=26) encounter children with dental trauma daily or weekly. TDI teaching during undergraduate training was received by 13% (n=12) of responders, and 32% (n=30) had never received training. Responders thought they would benefit from online resources and regular teaching on paediatric TDIs, in addition to an easy-to-use decision-making tool to signpost families.ED health professionals’ confidence in giving advice to families following a TDI, and in recognising types of TDIs, was notably low; −79 and −76 Net Promotor Score, respectively.Responders’ awareness of how to recognise and manage TDIs was varied. Majority were aware of the need to attempt to reimplant an avulsed permanent tooth, and the need to refer a child presenting with a complex permanent tooth injury to the oncall dentist. However, very few responders commented on the importance of follow-up. Responders also raised concerns about the lack of dental services to treat TDIs in children.ConclusionsThere is a need to enhance dental trauma teaching for all ED health professionals who encounter TDIs to increase their confidence and enable them to triage and advise patients appropriately. Additionally, increased signposting for families to the appropriate service could in turn improve outcomes and experience for children who experience a TDI.
Effectiveness and safety profile of greater occipital nerve blockade in cluster headache: a systematic review
Authors: Gordon Alexander , Roe Thomas , Villar-Martínez María Dolores , Moreno-Ajona David , Goadsby Peter J , Hoffmann Jan 
Published: March 2023

BackgroundGreater occipital nerve (GON) blockade is a short-term preventive therapy for cluster headache (CH). We conducted a systematic review to evaluate the effectiveness and safety of GON blockade in patients with CH.MethodsOn 23 October 2020, we searched MEDLINE, Embase, Embase Classic, PsycINFO, CINAHL, CENTRAL and Web of Science databases from their inception date. Studies included participants with a CH diagnosis who received corticosteroid and local anaesthetic suboccipital region injections. Outcomes were change in the frequency/severity/duration of attacks; proportion of participants responding to treatment, time to attack freedom from an attack, change in attack bout length and/or the presence of adverse effects after GON blockade. Risk of bias was assessed with the Cochrane Risk of Bias V.2.0 (RoB2)/Risk of Bias in Non-randomized Studies - of Interventions (ROBINS- I) tools and a specific tool for case reports/series.ResultsTwo RCTs, eight prospective and eight retrospective studies, and four case reports were included in the narrative synthesis. Every effectiveness study found a significant response in one or more of frequency/severity/duration of individual attacks or proportion of patients responding to treatment (47.8%–100.0%). There were five instances of potentially irreversible adverse effects. A higher injectate volume and use of concurrent prophylaxis may be associated with an increased likelihood of response. Methylprednisolone may have the best safety profile of available corticosteroids.DiscussionGON blockade is safe and effective for CH prevention. Higher injectate volumes may improve likelihood of response, and the likelihood of serious adverse events may be reduced by using methylprednisolone.PROSPERO registration numberCRD42020208435.
Methodological quality of systematic reviews of the local management of anogenital warts: a systematic review using AMSTAR II, ROBIS and PRISMA
Authors: Desmoulin Anissa , Joly Elisa , Tran Phuong , Derancourt Christian , Bertolotti Antoine 
Published: March 2023

IntroductionAnogenital warts (AGWs) are among the most common STDs. Many therapy options are available but are not codified. Systematic reviews (SRs) and meta-analyses (MAs) are helpful to elaborate recommendations on the management of AGWs. The objective of our study was to assess the quality and consistency of SRs for the local management of AGWs using three international tools.MethodsSeven electronic databases were searched from inception to 10 January 2022 for this SR. The intervention of interest was any local treatment of AGWs. There was no restriction on language and population. The methodological quality, reporting quality and risk of bias (ROB) of the included SRs for the local treatments of AGWs were assessed independently by two investigators with A Measurement Tool to Assess systematic Reviews version II (AMSTAR II), Risk of Bias in Systematic Reviews (ROBIS) and Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA).ResultsTwenty-two SRs/MAs met all inclusion criteria. According to the results of the AMSTAR II, nine included reviews were rated critically as being of low quality, and only five were of high quality. Based on the ROBIS tool, only nine SRs/MAs had a low ROB. The domain-assessed ‘study eligibility criteria’ were mostly rated at a low ROB, unlike the other domains. With PRISMA, the reporting checklist was relatively complete for ten SRs/MAs, but some reporting weaknesses remained in the topics of the abstract, protocol and registration, ROB and funding.DiscussionSeveral therapy options are available for the local management of AGWs and are widely studied. However, due to the many ROB and low quality of these SRs/MAs, only a few of them have the sufficient methodological quality to support guidelines.PROSPERO registration numberCRD42021265175.
Inhaled pirfenidone solution (AP01) for IPF: a randomised, open-label, dose–response trial
Authors: West Alex , Chaudhuri Nazia , Barczyk Adam , Wilsher Margaret L , Hopkins Peter , Glaspole Ian , Corte Tamera Jo , Šterclová Martina , Veale Antony , Jassem Ewa , Wijsenbeek Marlies S , Grainge Christopher , Piotrowski Wojciech , Raghu Ganesh , Shaffer Michele L , Nair Deepthi , Freeman Lisa , Otto Kelly , Montgomery A Bruce 
Published: March 2023

IntroductionOral pirfenidone reduces lung function decline and mortality in patients with idiopathic pulmonary fibrosis (IPF). Systemic exposure can have significant side effects, including nausea, rash, photosensitivity, weight loss and fatigue. Reduced doses may be suboptimal in slowing disease progression.MethodsThis phase 1b, randomised, open-label, dose–response trial at 25 sites in six countries (Australian New Zealand Clinical Trials Registry (ANZCTR) registration number ACTRN12618001838202) assessed safety, tolerability and efficacy of inhaled pirfenidone (AP01) in IPF. Patients diagnosed within 5 years, with forced vital capacity (FVC) 40%–90% predicted, and intolerant, unwilling or ineligible for oral pirfenidone or nintedanib were randomly assigned 1:1 to nebulised AP01 50 mg once per day or 100 mg two times per day for up to 72 weeks.ResultsWe present results for week 24, the primary endpoint and week 48 for comparability with published trials of antifibrotics. Week 72 data will be reported as a separate analysis pooled with the ongoing open-label extension study. Ninety-one patients (50 mg once per day: n=46, 100 mg two times per day: n=45) were enrolled from May 2019 to April 2020. The most common treatment-related adverse events (frequency, % of patients) were all mild or moderate and included cough (14, 15.4%), rash (11, 12.1%), nausea (8, 8.8%), throat irritation (5, 5.5%), fatigue (4, 4.4%) and taste disorder, dizziness and dyspnoea (three each, 3.3%). Changes in FVC % predicted over 24 and 48 weeks, respectively, were −2.5 (95% CI −5.3 to 0.4, −88 mL) and −4.9 (−7.5 to −2.3,–188 mL) in the 50 mg once per day and 0.6 (−2.2 to 3.4, 10 mL) and −0.4 (−3.2 to 2.3, −34 mL) in the 100 mg two times per day group.DiscussionSide effects commonly associated with oral pirfenidone in other clinical trials were less frequent with AP01. Mean FVC % predicted remained stable in the 100 mg two times per day group. Further study of AP01 is warranted.Trial registration numberACTRN12618001838202 Australian New Zealand Clinical Trials Registry.
Dynamical analysis in regularized 4D Einstein–Gauss–Bonnet gravity with non-minimal coupling
Authors: Bayarsaikhan Bilguun , Khimphun Sunly , Rithy Phearun , Tumurtushaa Gansukh 
Published: March 2023

AbstractWe investigate the regularized four-dimensional Einstein–Gauss–Bonnet (4DEGB) gravity with a non-minimal scalar coupling function, which is an extension of the regularized 4DEGB theory. By introducing non-minimal coupling to the Gauss-Bonnet term, we demonstrate the additional contribution to the dynamical equations which is otherwise absent in the dimensionally regularized theory. Furthermore, we analyze the stability of the system by using the dynamical system approach based on fixed points. Then, we consider time evolution to investigate the history of the universe and to constrain observational data to obtain the cosmological parameters of the model.
Stochastic Games with Synchronization Objectives
Authors: Doyen Laurent 
Published: March 2023

We consider two-player stochastic games played on a finite graph for infinitely many rounds. Stochastic games generalize both Markov decision processes (MDP) by adding an adversary player, and two-player deterministic games by adding stochasticity. The outcome of the game is a sequence of distributions over the graph states, representing the evolution of a population consisting of a continuum number of identical copies of a process modeled by the game graph. We consider synchronization objectives, which require the probability mass to accumulate in a set of target states, either always, once, infinitely often, or always after some point in the outcome sequence; and the winning modes of sure winning (if the accumulated probability is equal to 1) and almost-sure winning (if the accumulated probability is arbitrarily close to 1).
We present algorithms to compute the set of winning distributions for each of these synchronization modes, showing that the corresponding decision problem is PSPACE-complete for synchronizing once and infinitely often and PTIME-complete for synchronizing always and always after some point. These bounds are remarkably in line with the special case of MDPs, while the algorithmic solution and proof technique are considerably more involved, even for deterministic games. This is because those games have a flavor of imperfect information, in particular they are not determined and randomized strategies need to be considered, even if there is no stochastic choice in the game graph. Moreover, in combination with stochasticity in the game graph, finite-memory strategies are not sufficient in general.
Whole-genome and Epigenomic Landscapes of Malignant Gastrointestinal Stromal Tumors HarboringKITExon 11 557–558 Deletion Mutations
Authors: Ohshima Keiichi , Nagashima Takeshi , Fujiya Keiichi , Hatakeyama Keiichi , Watanabe Yuko , Morimoto Kimiko , Kamada Fukumi , Shimoda Yuji , Ohnami Sumiko , Naruoka Akane , Serizawa Masakuni , Ohnami Shumpei , Kenmotsu Hirotsugu , Shiomi Akio , Tsubosa Yasuhiro , Bando Etsuro , Sugiura Teiichi , Sugino Takashi , Terashima Masanori , Uesaka Katsuhiko , Urakami Kenichi , Akiyama Yasuto , Yamaguchi Ken 
Published: March 2023

Gastrointestinal stromal tumors (GIST) with KIT exon 11 deletions involving in codons 557–558 (KIT Δ557–558) exhibit higher proliferation rates and shorter disease-free survival times compared with GISTs with other KIT exon 11 mutations. We analyzed 30 GIST cases and observed genomic instability and global DNA hypomethylation only in high-risk malignant GISTs with KIT Δ557–558. Whole-genome sequencing revealed that the high-risk malignant GISTs with KIT Δ557–558 (12 cases) had more structural variations (SV), single-nucleotide variants, and insertions and deletions compared with the low-risk, less malignant GISTs with KIT Δ557–558 (six cases) and the high-risk (six cases) or low-risk (6 cases) GISTs with other KIT exon 11 mutations. The malignant GISTs with KIT Δ557–558 showed higher frequency and significance in copy number (CN) reduction on chromosome arms 9p and 22q, and 50% of them had LOH or CN-dependent expression reduction in CDKN2A. In addition, SVs with driver potential were detected in 75% of them, in which AKT3 and MGMT were recurrently identified. Genome-wide DNA methylation and gene expression analyses showed global intergenic DNA hypomethylation, SNAI2 upregulation, and higher expression signatures, including p53 inactivation and chromosomal instability, as characteristics of malignant GISTs with KIT Δ557–558 that distinguished them from other GISTs. These genomic and epigenomic profiling results revealed that KIT Δ557–558 mutations are associated with increased genomic instability in malignant GISTs.Significance:We present genomic and epigenomic insights into the malignant progression of GISTs with KIT exon 11 deletions involving in 557–558, demonstrating their unique chromosomal instability and global intergenic DNA hypomethylation.
Systemic LRG1 Expression in Melanoma is Associated with Disease Progression and Recurrence
Authors: Hoefsmit Esmee P. , Völlmy Franziska , Rozeman Elisa A. , Reijers Irene L.M. , Versluis Judith M. , Hoekman Liesbeth , van Akkooi Alexander C.J. , Long Georgina V. , Schadendorf Dirk , Dummer Reinhard , Altelaar Maarten , Blank Christian U. 
Published: March 2023

The response rates upon neoadjuvant immune checkpoint blockade (ICB) in stage III melanoma are higher as compared with stage IV disease. Given that successful ICB depends on systemic immune response, we hypothesized that systemic immune suppression might be a mechanism responsible for lower response rates in late-stage disease, and also potentially with disease recurrence in early-stage disease. Plasma and serum samples of cohorts of patients with melanoma were analyzed for circulating proteins using mass spectrometry proteomic profiling and Olink proteomic assay. A cohort of paired samples of patients with stage III that progressed to stage IV disease (n = 64) was used to identify markers associated with higher tumor burden. Baseline patient samples from the OpACIN-neo study (n = 83) and PRADO study (n = 49; NCT02977052) were used as two independent cohorts to analyze whether the potential identified markers are also associated with disease recurrence after neoadjuvant ICB therapy. When comparing baseline proteins overlapping between patients with progressive disease and patients with recurrent disease, we found leucine-rich alpha-2-glycoprotein 1 (LRG1) to be associated with worse prognosis. Especially nonresponder patients to neoadjuvant ICB (OpACIN-neo) with high LRG1 expression had a poor outcome with an estimated 36-month event-free survival of 14% as compared with 83% for nonresponders with a low LRG1 expression (P = 0.014). This finding was validated in an independent cohort (P = 0.0021). LRG1 can be used as a biomarker to identify patients with high risk for disease progression and recurrence, and might be a target to be combined with neoadjuvant ICB.

Significance:
LRG1 could serve as a potential target and as a biomarker to identify patients with high risk for disease recurrence, and consequently benefit from additional therapies and intensive follow-up.
Asymmetric Exchange Rate Pass Through to Consumer Prices: Evidence from Zambia
Authors: Fandamu Humphrey , Ndulo Manenga , Mudenda Dale , Fandamu Mercy 
Published: March 2023

The purpose of this study was to examine the asymmetric exchange rate pass through (ERPT) to consumer price inflation in Zambia. We examined ERPT to consumer price inflation arising from kwacha depreciation and appreciation for the period between the first quarter of 1985 to the fourth quarter of 2017. We employed the structural vector autoregressive model. The results showed that ERPT to consumer price inflation is incomplete and asymmetric. Consumer prices in Zambia are more responsive to kwacha depreciation than to appreciation. The depreciation of the kwacha has a greater significant impact on consumer prices than the appreciation of the kwacha. The impulse response function analysis showed that the shock to kwacha depreciation is very persistent than that of kwacha appreciation. Finally, the forecast error variance decomposition showed that a depreciation shock explains a bigger portion of the variance in consumer price inflation than an appreciation shock. These findings show that kwacha depreciation and appreciation have different effects on consumer price inflation, thereby confirming the presence of asymmetries in the ERPT. The study also accounted for the effect of commodity price booms in influencing ERPT. However, results of ERPT did not change much with the inclusion of commodity price booms. JEL Codes: E31, F31
From Teams to Teamness: Future Directions in the Science of Team Cognition
Authors: Cooke Nancy J. , Cohen Myke C. , Fazio Walter C. , Inderberg Laura H. , Johnson Craig J. , Lematta Glenn J. , Peel Matthew , Teo Aaron 
Published: March 2023

Objective We review the current state-of-the-art in team cognition research, but more importantly describe the limitations of existing theories, laboratory paradigms, and measures considering the increasing complexities of modern teams and the study of team cognition. Background Research on, and applications of, team cognition has led to theories, data, and measures over the last several decades. Method This article is based on research questions generated in a spring 2022 seminar on team cognition at Arizona State University led by the first author. Results Future research directions are proposed for extending the conceptualization of teams and team cognition by examining dimensions of teamness; extending laboratory paradigms to attain more realistic teaming, including nonhuman teammates; and advancing measures of team cognition in a direction such that data can be collected unobtrusively, in real time, and automatically. Conclusion The future of team cognition is one of the new discoveries, new research paradigms, and new measures. Application Extending the concepts of teams and team cognition can also extend the potential applications of these concepts.
Burnout and patient safety perceptions among surgeons in the United Kingdom during the early phases of the coronavirus disease 2019 pandemic: A two-wave survey
Authors: Al-Ghunaim Tmam , Johnson Judith , Biyani Chandra S , Yiasemidou Marina , O’Connor Daryl B 
Published: March 2023

Background Surgeons in the UK report high burnout levels. Burnout has been found to be associated with adverse patient outcomes but there are few studies that have examined this association in surgeons and even fewer which have examined this relationship over time. Purpose The main aim was to examine the relationships between surgeon burnout and surgeons’ perceptions of patient safety cross-sectionally and longitudinally. The secondary aim was to test whether surgeons’ burnout levels varied over the first six months of the coronavirus disease 2019 pandemic. Methods This paper reports data from a two-wave survey (first wave from 5 May and 30 June 2020, the second wave 5 January to 30 February 2021). The dataset was divided into a longitudinal group (for surgeons who responded at both the time points) and two cross-sectional groups (for surgeons who responded at a one-time point, but not the other). Results The first key finding was that burnout was associated with patient safety outcomes measured at the same time point (Group 1 = 108, r = 0.309 , p < 0.05 and Group 2 = 84, r = 0.238, p < 0.05). Second, burnout predicted poor patients’ safety perceptions over time, and poor patient safety predicted burnout over time (Group 3 = 39, p < 0.05). Third, burnout increased between the first and second surveys ( t = -4.034, p < 0.05). Conclusion Burnout in surgeons may have serious implications for patient safety. Interventions to support surgeons should be prioritised, and healthcare organisations, surgeons and psychological specialists should collaborate on their development.
Can automated CT body composition analysis predict high-grade Clavien–Dindo complications in patients with RCC undergoing partial and radical nephrectomy?
Authors: Demirel Emin , Dilek Okan 
Published: March 2023

Introduction This study investigated the relationship between body tissue composition analysis and complications according to the Clavien–Dindo classification in patients with renal cell carcinoma (RCC) who underwent partial (PN) or radical nephrectomies (RN). Methods We obtained all data of 210 patients with RCC from the 2019 Kidney and Kidney Tumor Segmentation Challenge (C4KC-KiTS) dataset and obtained radiological images from the cancer image archive. Body composition was assessed with automated artificial intelligence software using the convolutional network segmentation technique from abdominal computed tomography images. We included 125 PN and 63 RN in the study. The relationship between body fat and muscle tissue distribution and complications according to the Clavien–Dindo classification was evaluated between these two groups. Results Clavien–Dindo 3A and higher (high grade) complications were developed in 9 of 125 patients who underwent PN and 7 of 63 patients who underwent RN. There was no significant difference between all body composition values between patients with and without high-grade complications. Conclusion This study showed that body muscle-fat tissue distribution did not affect patients with 3A and above complications according to the Clavien–Dindo classification in patients who underwent nephrectomy due to RCC.
Compostability of wool textiles by soil burial
Authors: Hodgson Alexandra , Leighs Samuel James , van Koten Chikako 
Published: March 2023

Chemical processing has the potential to impact the composting of wool fabrics, influencing potential end of life options. The aim of this study was to investigate the comparative composting behaviors of a range of knitted and woven merino apparel fabrics. The range included scoured only control fabrics and variants which had undergone different chemical processes during manufacturing, including dyeing, bleaching, stain-repellence and various shrink-resist treatments. Biodegradation by composting was elicited by a soil-burial process incorporating three sets of randomized samples buried to a depth of 10 cm. Replicates were removed at regular intervals up to a maximum of 15 weeks burial. The dyes present in the fabric showed the greatest impact on composting. Chrome dyed samples exhibited only 60% mass loss over the trial period, whereas the other 10 fabrics all lost on average over 95%. When assessing easy care treatments, chlorine–Hercosett provided consistent initial resistance to decomposition. Soil burial test results suggested that chemical processing does impact the composting of wool fabrics, under the conditions of soil burial. Statistically significant longer-term effects were only observed for the chrome dyed sample.  • Chemical processing of wool fabrics influences the onset of composting as a result of soil burial.  • Dyeing fabrics had the greatest impact on the onset of composting as a result of soil burial.  • Machine-washable wool has initial resistance to decomposition, compared with untreated wool, as a result of soil burial.