bluuebunny/crossref_metadata_2025_split huggingface dataset:
Korean NGOs and Reconciliation with Japan
Authors: Easley Leif-Eric 
Published: February 2023

AbstractStrained South Korea–Japan ties are frequently attributed to the use and abuse of history by national leaders. This article considers a more bottom-up explanation by examining how Korean civil society is taking three different pathways to exert influence on bilateral relations. First, non-governmental organizations are expanding domestic and international awareness of grievances regarding Japan's 1910–1945 colonization of the Korean Peninsula. Second, activists are pushing court cases in attempts to change legal interpretations and government policies. Third, certain civic groups demand maximalist positions on history and stigmatize cooperation with Tokyo. While influential over Korean public opinion, these efforts win few hearts and minds in Japan and complicate productive diplomacy. With particular attention to the 2015 Korea–Japan agreement for “comfort women” survivors and the 2018 South Korean Supreme Court decisions on wartime labor, this article unpacks the relationship between activist Korean civil society and historical reconciliation with Japan, offering implications for foreign policy and state-society relations.
WHEN IS A NUMERICAL SEMIGROUP A QUOTIENT?
Authors: BOGART TRISTRAM , O’NEILL CHRISTOPHER , WOODS KEVIN 
Published: February 2023

AbstractA natural operation on numerical semigroups is taking a quotient by a positive integer. If
$\mathcal {S}$
is a quotient of a numerical semigroup with k generators, we call
$\mathcal {S}$
a k-quotient. We give a necessary condition for a given numerical semigroup
$\mathcal {S}$
to be a k-quotient and present, for each
$k \ge 3$
, the first known family of numerical semigroups that cannot be written as a k-quotient. We also examine the probability that a randomly selected numerical semigroup with k generators is a k-quotient.
Populism and Democratic Conflict: An Aristotelian View
Authors: Polansky David 
Published: February 2023

AbstractPopulism has lately become a matter of concern in both popular and academic circles. Yet contemporary writers have had difficulty parsing populism's relationship to democracy, partly because they are universally committed to the latter. It is worth turning to a thinker like Aristotle, who—despite not explicitly addressing populism itself—is able to reflect clearly on various democratic phenomena that we tend to consider populist, because he does not share our normative or analytical assumptions about democracy. Aristotle's discussions in books 3 and 4 of the Politics allow us to see that what we call populism is a function of a broader problem of class conflict in democracies. In light of this analysis, we can see populist movements not as an external challenge to the democratic regime, but rather as a characteristic expression of a recurring dispute over the contours and prerogatives of the people.
Targeting drug lords: Challenges to IHL between lege lata and lege ferenda
Authors: Redaelli Chiara , Arévalo Carlos 
Published: February 2023

AbstractThis article aims to clarify how international humanitarian law (IHL) rules on targeting apply when drug cartels are party to a non-international armed conflict. The question of distinguishing between a cartel's armed forces and the rest of the cartel members is a pertinent matter. It is crucial to avoid considering every drug dealer a legitimate target, just as we do not consider that everyone working for the government is a legitimate target. Nevertheless, it is unclear at what point a member of a cartel would change from being a criminal to being a member of the armed wing of the cartel, hence becoming a legitimate target. The present article will suggest a teleological approach to solving this conundrum.
Emancipation and Imperialism in a Borderland: The Challenge to Settler Sovereignty over Slavery in Belize in the 1820s
Authors: Dutt Rajeshwari 
Published: February 2023

AbstractThis article points to the 1820s as a crucial period that saw a great reversal in the location of sovereignty in Belize. The article employs two inflection points—first, an 1822 case of ‘Indian’ slaves from Mosquito Shore, and second, slave desertion in 1825—to point to unprecedented challenges to settler sovereignty over slavery in Belize that arose during the 1820s. While British amelioration allowed the metropolitan government to bring frontier and borderland regions within its legal purview, thus challenging settler autonomy, the concurrent event of Central American emancipation provided enslaved people in Belize additional opportunity to desert their masters at a moment when restitution of runaway slaves became increasingly difficult. Yet, this essay is about more than just the fracturing of settler sovereignty over slavery. Rather it also illuminates how settlers responded to these challenges by using force, diplomacy, and the print media. The settlers’ most potent response was in portraying Belizean slavery as ‘benign,’ creating a surprisingly robust narrative that would endure for generations. The essay illuminates how emancipation and imperialism remained inextricably linked in borderland areas such as Belize, which straddled the boundaries between Spanish America and the British Caribbean.
Spatial and Temporal Quantification of Subaerial Volcanism From 1980 to 2019: Solid Products, Masses, and Average Eruptive Rates
Authors: Galetto Federico , Pritchard Matthew E. , Hornby Adrian J. , Gazel Esteban , Mahowald Natalie M. 
Published: February 2023

AbstractVolcanism is one of the main mechanisms transferring mass and energy between the interior of the Earth and the Earth's surface. However, the global mass flux of lava, volcanic ash and explosive pyroclastic deposits is not well constrained. Here we review published estimates of the mass of the erupted products from 1980 to 2019 by a global compilation. We identified 1,064 magmatic eruptions that occurred between 1980 and 2019 from the Smithsonian Global Volcanism Program database. For each eruption, we reported both the total erupted mass and its partitioning into the different volcanic products. Using this data set, we quantified the temporal and spatial evolution of subaerial volcanism and its products from 1980 to 2019 at a global and regional scale. The mass of magma erupted in each analyzed decade ranged from 1.1–4.9 × 1013 kg. Lava is the main subaerial erupted product representing ∼57% of the total erupted mass of magma. The products related to the biggest eruptions (Magnitude ≥6), with long recurrence times, can temporarily make explosive products more abundant than lava (e.g., decade 1990–1999). Twenty‐three volcanoes produced ∼72% of the total mass, while two different sets of 15 volcanoes erupted >70% of the total mass of either effusive or explosive products. At a global scale, the 10 and 40‐year average eruptive rates calculated from 1980 to 2019 have the same magnitude as the long‐term average eruptive rates (from thousand to millions of years), because in both cases rates are scaled for times comparable to the recurrence time of the biggest eruptions occurred.
Land Surfaces at the Tipping‐Point for Water and Energy Balance Coupling
Authors: Dong Jianzhi , Akbar Ruzbeh , Feldman Andrew F. , Gianotti Daniel Short , Entekhabi Dara 
Published: February 2023

AbstractThe surface water and energy balances can be coupled or uncoupled depending on whether the evaporation regime is water‐limited or energy‐limited. As the landscape loses soil moisture during drydowns, a transition between the regimes may occur, which signifies a nonlinear change in water‐energy‐carbon coupling. Regions that switch often between these two regimes, that is, are dominated by neither regime, are particularly vulnerable to climate variability and change. To robustly identify these tipping points, we identify drydown events based on global soil moisture data sets from remote sensing. The event identification does not rely on precipitation information and is robust with respect to measurement noise. Then, the soil moisture thresholds delineating the evaporation regime transitions are determined by Sequential Monte Carlo Sampling and a two‐stage parametrization strategy. Based on the estimated soil moisture thresholds across the globe, we estimate observation‐based water availability indices which quantify the nonlinear controls of soil moisture on evaporation. This framework is tested and applied globally using Soil Moisture Active Passive soil moisture retrievals. Combined with a new tippling‐point metric that describes the frequency of evaporation regime transitions, we identify regions that switch often between different evaporation regimes at the global scale. Given unit shifts in soil moisture, these regions will experience the most change in how their surface water and energy are coupled.
Effect of Seepage Velocity on Pore Clogging Growth Behavior and Its Effect on Permeability Reduction During Fines Migration in Porous Media
Authors: Han Gyeol , Kwon Tae‐Hyuk 
Published: February 2023

AbstractFines migration driven by fluid flows often causes pore clogging in porous media and thus reduces the permeability of the porous media. The clogging can pose serious problems in various practices, such as formation damage in hydrocarbon reservoirs, degradation of fluid withdrawal or injection efficiency, particle‐induced fouling in filtration membranes, or even a risk of sediment failure with geostructures. However, the effect of seepage flow velocity on the spatial growth pattern of fines‐induced pore clogging remains poorly identified. This study explores the pore clogging growth behaviors caused by flow‐driven fines migration and accumulation in porous media and the associated permeability reductions through a series of column experiments and concurrent X‐ray computed tomography imaging. Particularly, the X‐ray image analysis captures the spatial distributions of fines, and thus the homogeneous or heterogeneous (localized) clogging growth pattern under various seepage velocities. Our results reveal that an increase in the seepage flow velocity increases the likelihood of localized clogging growth, attributable to the direct interception of fines by the sand grains. The localized clogging growth causes a faster reduction in permeability than the homogeneous clogging growth. The presented study provides well‐controlled experiment data on fines distribution and associated permeability change, which gives insights into fines‐induced clogging behavior in porous media.
Impact of Matrix Diffusion on Heat Transport Through Heterogeneous Fractured Aquifers
Authors: De Simone Silvia , Bour Olivier , Davy Philippe 
Published: February 2023

AbstractHeat transport in fractured aquifers is determined by the combined effects of flow velocity heterogeneity in the fracture system, and diffusive exchange between the fluid in the fractures and the rock matrix, which can be assumed as impervious. We analyze the impacts of this diffusive exchange on the response to heat transport, as opposite to the pure advective displacement, which governs solute transport. We focus on the post‐peak behavior where we observe pre‐asymptotic regimes with slopes that differ from the signature of matrix diffusion, which exhibits a decay rate of −3/2. This deviation is driven by the variability of both velocity field and fracture aperture field. We derive theoretical models that predict these pre‐asymptotic tails under three extreme cases that can be related with specific network structures, that is, networks dominated by large or small fractures, networks with highly or poorly channelized flow. These theoretical predictions are compared with results from numerical simulations in different sets of three‐dimensional discrete fracture networks. We determine that the combined observation of solute and heat transport responses allows classifying the network in terms of connectivity structure, and partially characterizing the fracture aperture variability in terms of upscaled parameters.
Activating transcription factor-2 supports the antioxidant capacity and ability of human mesenchymal stem cells to prevent asthmatic airway inflammation
Authors: Ju Hyein , Yun HongDuck , Kim YongHwan , Nam Yun Ji , Lee Seungun , Lee Jinwon , Jeong Seon Min , Heo Jinbeom , Kwon Hyungu , Cho You Sook , Jeong Gowun , Ryu Chae-Min , Shin Dong-Myung 
Published: February 2023

AbstractGlutathione (GSH), an abundant nonprotein thiol antioxidant, participates in several biological processes and determines the functionality of stem cells. A detailed understanding of the molecular network mediating GSH dynamics is still lacking. Here, we show that activating transcription factor-2 (ATF2), a cAMP-response element binding protein (CREB), plays a crucial role in maintaining the level and activity of GSH in human mesenchymal stem cells (MSCs) by crosstalking with nuclear factor erythroid-2 like-2 (NRF2), a well-known master regulator of cellular redox homeostasis. Priming with ascorbic acid 2-glucoside (AA2G), a stable vitamin C derivative, increased the expression and activity of ATF2 in MSCs derived from human embryonic stem cells and umbilical cord. Subsequently, activated ATF2 crosstalked with the CREB1-NRF2 pathway to preserve the GSH dynamics of MSCs through the induction of genes involved in GSH synthesis (GCLC and GCLM) and redox cycling (GSR and PRDX1). Accordingly, shRNA-mediated silencing of ATF2 significantly impaired the self-renewal, migratory, proangiogenic, and anti-inflammatory capacities of MSCs, and these defects were rescued by supplementation of the cells with GSH. In addition, silencing ATF2 attenuated the ability of MSCs to alleviate airway inflammatory responses in an ovalbumin-induced mouse model of allergic asthma. Consistently, activation of ATF2 by overexpression or the AA2G-based priming procedure enhanced the core functions of MSCs, improving the in vivo therapeutic efficacy of MSCs for treating asthma. Collectively, our findings suggest that ATF2 is a novel modulator of GSH dynamics that determines the core functionality and therapeutic potency of MSCs used to treat allergic asthma.
Nuclear receptor 5A2 regulation of Agrp underlies olanzapine-induced hyperphagia
Authors: Zapata Rizaldy C. , Zhang Dinghong , Libster Avraham , Porcu Alessandra , Montilla-Perez Patricia , Nur Aisha , Xu Baijie , Zhang Zhi , Correa Stephanie M. , Liu Chen , Telese Francesca , Osborn Olivia 
Published: February 2023

AbstractAntipsychotic (AP) drugs are efficacious treatments for various psychiatric disorders, but excessive weight gain and subsequent development of metabolic disease remain serious side effects of their use. Increased food intake leads to AP-induced weight gain, but the underlying molecular mechanisms remain unknown. In previous studies, we identified the neuropeptide Agrp and the transcription factor nuclear receptor subfamily 5 group A member 2 (Nr5a2) as significantly upregulated genes in the hypothalamus following AP-induced hyperphagia. While Agrp is expressed specifically in the arcuate nucleus of the hypothalamus and plays a critical role in appetite stimulation, Nr5a2 is expressed in both the CNS and periphery, but its role in food intake behaviors remains unknown. In this study, we investigated the role of hypothalamic Nr5a2 in AP-induced hyperphagia and weight gain. In hypothalamic cell lines, olanzapine treatment resulted in a dose-dependent increase in gene expression of Nr5a2 and Agrp. In mice, the pharmacological inhibition of NR5A2 decreased olanzapine-induced hyperphagia and weight gain, while the knockdown of Nr5a2 in the arcuate nucleus partially reversed olanzapine-induced hyperphagia. Chromatin-immunoprecipitation studies showed for the first time that NR5A2 directly binds to the Agrp promoter region. Lastly, the analysis of single-cell RNA seq data confirms that Nr5a2 and Agrp are co-expressed in a subset of neurons in the arcuate nucleus. In summary, we identify Nr5a2 as a key mechanistic driver of AP-induced food intake. These findings can inform future clinical development of APs that do not activate hyperphagia and weight gain.
O-GlcNAcylation of YTHDF2 promotes HBV-related hepatocellular carcinoma progression in an N6-methyladenosine-dependent manner
Authors: Yang Yang , Yan Yu , Yin Jiaxin , Tang Ni , Wang Kai , Huang Luyi , Hu Jie , Feng Zhongqi , Gao Qingzhu , Huang Ailong 
Published: February 2023

AbstractHepatitis B virus (HBV) infection is a major risk factor for hepatocellular carcinoma (HCC), but its pathogenic mechanism remains to be explored. The RNA N6-methyladenosine (m6A) reader, YTH (YT521-B homology) domain 2 (YTHDF2), plays a critical role in the HCC progression. However, the function and regulatory mechanisms of YTHDF2 in HBV-related HCC remain largely elusive. Here, we discovered that YTHDF2 O-GlcNAcylation was markedly increased upon HBV infection. O-GlcNAc transferase (OGT)-mediated O-GlcNAcylation of YTHDF2 on serine 263 enhanced its protein stability and oncogenic activity by inhibiting its ubiquitination. Mechanistically, YTHDF2 stabilized minichromosome maintenance protein 2 (MCM2) and MCM5 transcripts in an m6A-dependent manner, thus promoting cell cycle progression and HBV-related HCC tumorigenesis. Moreover, targeting YTHDF2 O-GlcNAcylation by the OGT inhibitor OSMI-1 significantly suppressed HCC progression. Taken together, our findings reveal a new regulatory mechanism for YTHDF2 and highlight an essential role of YTHDF2 O-GlcNAcylation in RNA m6A methylation and HCC progression. Further description of the molecular pathway has the potential to yield therapeutic targets for suppression of HCC progression due to HBV infection.
The phosphorylation of PHF5A by TrkA-ERK1/2-ABL1 cascade regulates centrosome separation
Authors: Song Chen , Zhang Yu , Li Yutong , Bie Juntao , Wang Zhe , Yang Xin , Li Haishuang , Zhu Liangyi , Zhang Tianzhuo , Chang Qing , Luo Jianyuan 
Published: February 2023

AbstractDuring interphase, the newly duplicated pairs of centrosomes are held together by a centrosome linker, and the centrosome separation needs the disruption of this linker to induce the duplicated centrosomes separating into two distinct microtubule organization centers. The mechanism of regulating centrosome separation is however poorly understood. Here, we demonstrated that the phosphorylation of PHF5A at Y36 by the TrkA-ERK1/2-ABL1 cascade plays a critical role in regulating centrosome separation. PHF5A, a well-characterized spliceosome component, is enriched in the centrosome. The pY36-PHF5A promotes the interaction between CEP250 and Nek2A in a spliceosomal-independent manner, which leads to premature centrosome separation. Furthermore, the unmatured centrosome remodels the microtubule and subsequently regulates cell proliferation and migration. Importantly, we found that the phosphorylation cascade of TrkA-ERK1/2-ABL1-PHF5A is hyper-regulated in medulloblastoma. The inhibition of this cascade can induce senescence and restrict the proliferation of medulloblastoma. Our findings on this phosphorylation cascade in regulating centrosome separation could provide a series of potential targets for restricting the progress of medulloblastoma.
MLKL deficiency attenuated hepatocyte oxidative DNA damage by activating mitophagy to suppress macrophage cGAS-STING signaling during liver ischemia and reperfusion injury
Authors: Xu Jian , Wu Dongming , Zhou Shun , Hu Haoran , Li Fei , Guan Zhu , Zhan Xinyu , Gao Yiyun , Wang Ping , Rao Zhuqing 
Published: February 2023

AbstractMixed-lineage kinase domain-like protein (MLKL)-mediated necroptosis has been implicated in aggravating liver ischemia and reperfusion (IR) injury. However, the precise role and mechanism of MLKL in regulating oxidative DNA damage of hepatocytes and subsequent activation of macrophage stimulator of interferon genes (STING) signaling remains unclear. In this study, we investigated the role of MLKL in regulating the interplay between hepatocyte injury and macrophage pro-inflammatory responses during liver IR injury. We found that IR increased MLKL expression in liver tissues of wild type (WT) mice. MLKL knockout (KO) attenuated liver IR injury and suppressed the activation of cGAS-STING signaling in intrahepatic macrophages, which was abrogated by STING activation with its agonist. Mechanistically, IR induced oxidative DNA damage in hepatocytes, leading to cGAS-STING activation in macrophages, which was suppressed by MLKL KO. Moreover, increased PTEN-induced kinase 1 (PINK1)-mediated mitophagy contributed to reduced oxidative DNA damage in hepatocytes and subsequent decreased activation of STING signaling in macrophages in MLKL KO mice. Our findings demonstrated a non-canonical role of MLKL in the pathogenesis of liver IR. MLKL deficiency significantly promoted PINK1-mediated mitophagy activation to inhibit oxidative DNA damage in hepatocytes, which in turn suppressed macrophage cGAS-STING activation and inflammatory liver IR injury.
Human epidermal growth factor receptor 3 serves as a novel therapeutic target for acral melanoma
Authors: Tanaka Yuka , Ito Takamichi , Kaku-Ito Yumiko , Tanegashima Keiko , Tsuji Gaku , Kido-Nakahara Makiko , Oda Yoshinao , Nakahara Takeshi 
Published: February 2023

AbstractAcral melanoma (AM) is a rare, life-threatening skin cancer. Since AM bears unique features, existing therapies for other types of malignant melanomas have limited effects and the establishment of effective treatments for AM is strongly desired. Human epidermal growth factor receptor 3 (HER3) is a receptor tyrosine kinase that is frequently elevated in tumors and contributes to tumor progression, so it is considered a promising therapeutic target for tumors. This study was established to evaluate the potential of HER3-targeted therapy to treat AM by investigating the expression and function of HER3. HER3 expression was immunohistochemically analyzed in AM lesions of 72 patients and in AM cell lines. To investigate function of HER3, effects of HER3 inhibition on cell proliferation, apoptosis/survival, anchorage-independent growth, and underlying signals were assessed. HER3 was expressed in patients’ AM tissues with various intensities and HER3 expression was significantly correlated with patient’s disease-free survival. In vitro analyses revealed that HER3 is more highly expressed in AM cells than in normal epidermal melanocytes. AM cells were also shown to be sensitive to the cytotoxic part of a HER3-targeted antibody-drug conjugate. Inhibition of HER3 did not affect cell proliferation, whereas it decreased the anchorage-independent growth of AM cells likely through affecting the nuclear translocation of Yes-associated protein. It is implied that HER3 may serve as a novel therapeutic target for AM.