bluuebunny/crossref_metadata_2025_split huggingface dataset:
Imaging of pituitary tumors: an update with the 5th WHO Classifications—part 2. Neoplasms other than PitNET and tumor-mimicking lesions
Authors: Tsukamoto Taro , Miki Yukio 
Published: March 2023

AbstractMany types of tumors can develop in the pituitary gland. In the recently revised 5th editions of the World Health Organization (WHO) classifications (2021 WHO Classification of Central Nervous System Tumors and the 2022 WHO Classification of Endocrine and Neuroendocrine Tumors), various changes have been made to the tumors other than pituitary neuroendocrine tumor (PitNET)/pituitary adenoma, as well as PitNET. Adamantinomatous craniopharyngioma and papillary craniopharyngioma are now considered separate tumors in the 5th edition of the WHO classification. Tumors positive for thyroid transcription factor 1, a marker of posterior pituitary cells, are now grouped together in the pituicyte tumor family in the 5th edition of the WHO classification of Endocrine and Neuroendocrine Tumors. Poorly differentiated chordoma is newly listed in the 5th edition of the WHO Classification of Endocrine and Neuroendocrine Tumors. In this paper, we present the latest WHO classification of pituitary tumors (adamantinomatous craniopharyngioma, papillary craniopharyngioma, pituitary blastoma, pituicyte tumor family, tumors of pituitary origin other than those of the pituicyte tumor family, germinoma, meningioma, chordoma, metastatic tumors, lymphoma, and pituitary incidentaloma), review diseases requiring differentiation from tumors (pituitary abscess, hypophysitis, pituitary hyperplasia, Rathke’s cleft cyst, arachnoid cyst, and aneurysm), and discuss diagnoses based on imaging findings.
Robotic-assisted pyeloplasty in children: a systematic review of the literature
Authors: Esposito Ciro , Cerulo Mariapina , Lepore Benedetta , Coppola Vincenzo , D’Auria Daniela , Esposito Giorgia , Carulli Roberto , Del Conte Fulvia , Escolino Maria 
Published: March 2023

AbstractRobotic pyeloplasty has become a natural progression from the development of open, then laparoscopic procedures to treat pediatric patients with ureteropelvic junction obstruction (UPJO). Robotic-assisted pyeloplasty (RALP) is now considered a new gold standard in pediatric MIS. A systematic review of the literature retrieved from PubMed and published in the last 10 years (2012–2022) was performed. This review underlines that in all children except the smallest infants, where the open procedure has benefits in terms of duration of general anesthetic and there are limitations in the size of instruments, robotic pyeloplasty is becoming the preferred procedure to perform in patients with UPJO. Results for the robotic approach are extremely promising, with shorter operative times than laparoscopy and equal success rates, length of stay and complications. In case of redo pyeloplasty, RALP is easier to perform than other open or MIS procedures. By 2009, robotic surgery became the most used modality to treat all UPJO and continues to grow in popularity. Robot-assisted laparoscopic pyeloplasty in children is safe and effective with excellent outcomes, even in redo pyeloplasty or challenging anatomical cases. Moreover, robotic approach shortens the learning curve for junior surgeons, who can readily achieve levels of expertise comparable to senior practitioners. However, there are still concerns regarding the cost associated with this procedure. Further high-quality prospective observational studies and clinical trials, as well as new technologies specific for the pediatric population, are advisable for RALP to reach the level of gold standard.
Real-world performance analysis of a novel computational method in the precision oncology of pediatric tumors
Authors: Vodicska Barbara , Déri Júlia , Tihanyi Dóra , Várkondi Edit , Kispéter Enikő , Dóczi Róbert , Lakatos Dóra , Dirner Anna , Vidermann Mátyás , Filotás Péter , Szalkai-Dénes Réka , Szegedi István , Bartyik Katalin , Gábor Krisztina Míta , Simon Réka , Hauser Péter , Péter György , Kiss Csongor , Garami Miklós , Peták István 
Published: March 2023

AbstractBackgroundThe utility of routine extensive molecular profiling of pediatric tumors is a matter of debate due to the high number of genetic alterations of unknown significance or low evidence and the lack of standardized and personalized decision support methods. Digital drug assignment (DDA) is a novel computational method to prioritize treatment options by aggregating numerous evidence-based associations between multiple drivers, targets, and targeted agents. DDA has been validated to improve personalized treatment decisions based on the outcome data of adult patients treated in the SHIVA01 clinical trial. The aim of this study was to evaluate the utility of DDA in pediatric oncology.MethodsBetween 2017 and 2020, 103 high-risk pediatric cancer patients (< 21 years) were involved in our precision oncology program, and samples from 100 patients were eligible for further analysis. Tissue or blood samples were analyzed by whole-exome (WES) or targeted panel sequencing and other molecular diagnostic modalities and processed by a software system using the DDA algorithm for therapeutic decision support. Finally, a molecular tumor board (MTB) evaluated the results to provide therapy recommendations.ResultsOf the 100 cases with comprehensive molecular diagnostic data, 88 yielded WES and 12 panel sequencing results. DDA identified matching off-label targeted treatment options (actionability) in 72/100 cases (72%), while 57/100 (57%) showed potential drug resistance. Actionability reached 88% (29/33) by 2020 due to the continuous updates of the evidence database. MTB approved the clinical use of a DDA-top-listed treatment in 56 of 72 actionable cases (78%). The approved therapies had significantly higher aggregated evidence levels (AELs) than dismissed therapies. Filtering of WES results for targeted panels missed important mutations affecting therapy selection.ConclusionsDDA is a promising approach to overcome challenges associated with the interpretation of extensive molecular profiling in the routine care of high-risk pediatric cancers. Knowledgebase updates enable automatic interpretation of a continuously expanding gene set, a “virtual” panel, filtered out from genome-wide analysis to always maximize the performance of precision treatment planning.
CatSight, a direct path to proper multi-variate time series change detection: perceiving a concept drift through common spatial pattern
Authors: Flórez Arantzazu , Rodríguez-Moreno Itsaso , Artetxe Arkaitz , Olaizola Igor García , Sierra Basilio 
Published: March 2023

AbstractDetecting changes in data streams, with the data flowing continuously, is an important problem which Industry 4.0 has to deal with. In industrial monitoring, the data distribution may vary after a change in the machine’s operating point; this situation is known as concept drift, and it is key to detecting this change. One drawback of conventional machine learning algorithms is that they are usually static, trained offline, and require monitoring at the input level. A change in the distribution of data, in the relationship between the input and the output data, would result in the deterioration of the predictive performance of the models due to the lack of an ability to generalize the model to new concepts. Drift detecting methods emerge as a solution to identify the concept drift in the data. This paper proposes a new approach for concept drift detection—a novel approach to deal with sudden or abrupt drift, the most common drift found in industrial processes-, called CatSight. Briefly, this method is composed of two steps: (i) Use of Common Spatial Patterns (a statistical approach to deal with data streaming, closely related to Principal Component Analysis) to maximize the difference between two different distributions of a multivariate temporal data, and (ii) Machine Learning conventional algorithms to detect whether a change in the data flow has been occurred or not. The performance of the CatSight method, has been evaluated on a real use case, training six state of the art Machine Learning (ML) classifiers; obtained results indicate how adequate the new approach is.
Effect of garden and park waste hydrochar and biochar in soil application: a comparative study
Authors: Suarez Eneko , Tobajas Montserrat , Mohedano Angel F. , Reguera Maria , Esteban Elvira , de la Rubia Angeles 
Published: March 2023

AbstractThe
thermochemical treatments of biowaste yield alternative renewable carbon-rich materials, while achieving waste valorization. These technologies allow to reduce amount of biowaste and enhance its life span avoiding the landfill disposal. The agronomic application as a soil amendment strategy using fresh hydrochar (obtained via the hydrothermal treatment of garden and park waste (GPW) at 180 °C for 1 h), post-treated hydrochar (washed, aged, and thermally treated), and biochar (obtained via the pyrolysis of GPW at 900 °C for 90 min) has been studied and compared in order to stablish the best approach for its valorization. We evaluated the effects of mixing fresh hydrochar (1–5% on dry weight) with different peat-based growth substrates on the seed germination index as well as the fresh and dry weights of Arabidopsis thaliana, Chenopodium quinoa, and Solanum lycopersicum (tomato). We also performed a germination assay with marginal agricultural soil mixed with fresh and post-treated chars as well as biochar using the same doses. All carbonaceous materials complied with the European legal framework being categorized as a class A amendment and present a favorable chemical composition for their agronomic use, carbon sources with a low heavy-metal content, and a high mineral and organic matter content. Application of post-treated hydrochar to the agricultural marginal soil improved the germination index of tomato seeds (by 10–20%) at low dosages (< 3% on dry weight) when washed and thermally treated hydrochar was used. However, fresh hydrochar negatively affected seed germination and plant growth when applied to marginal soil and peat-based growth media, particularly sandy substrates. Washing improved the germination index (by approximately 18%), reduced 90% of the total volatile fatty acid content, and effectively removed furans, amines, amides, pyridines, pyrazines, benzoic compounds, and organic acids that can affect seed germination and plant growth. Because the use of hydrochar in soils for agricultural purposes requires post-treatment to alleviate germination and plant growth inhibition, washing is the most suitable option considering the energy and technological requirements.
A New Method in Applying the Universal Wave Equation to Measure the Speed of Sound in Water as a Function of Temperature with Low Frequency Ultrasound
Authors: Check G. R. , Watson I. A. 
Published: March 2023

AbstractA new methodology was used to determine the speed of sound in water by using low frequency ultrasound over the temperature range 20 to 95° C. The initial procedure was developed based on finding the resonant locations over variable pathlengths in an acoustic tube and calculating their separation distances through the water, yielding the wavelength (λ) measurement. An in-house gain detector was employed to detect the resonant points, through detection of the amplitude voltage peaks in response to the displacement of the moving transmitter. The λ was calculated as 53 mm for water at 20° C with the fixed frequency of 28 kHz. As a result, using the universal wave equation, the speed of sound was estimated to be 1484 m/s with an accuracy of 99.89% compared to the references. The methodology was then followed through the second procedure to measure the sound speeds at temperatures higher than 20 °C, using coincidence frequency determination over different temperatures. In a fixed acoustic pathlength equal to the calculated λ at 20° C, the initial frequency, 28 kHz, was linearly swept to track the coincidence frequency corresponding to certain temperatures. The gain detector was used to obtain the coincidence frequencies, wherein the amplitude voltage peaks were recorded during the frequency adjustment. The simultaneous monitoring with an oscilloscope consolidated data when the phase differences between radiated and received waves were eliminated at the coincidence frequencies. The measured coincidence frequencies were then directly used to determine the speed of sound in water as function of temperature. The third order curve fitted to the results yielded an R2 equal to 0.9856, representing excellent agreement with the reference data.
Accuracy of high-order, discrete approximations to the lifting-line equation
Authors: Coder J.G. 
Published: March 2023

AbstractThe accuracy of several numerical schemes for solving the lifting-line equation is investigated. Circulation is represented on discrete elements using polynomials of varying degree, and a novel scheme is introduced based on a discontinuous representation that permits arbitrary polynomial degrees to be used. Satisfying the Helmholtz theorems at inter-element boundaries penalises the discontinuities in the circulation distribution, which helps ensure the solution converges towards the correct, continuous behaviour as the number of elements increases. It is found that the singular vorticity at the wing tips drives the leading-order error of the solution. With constant panel widths, numerical schemes exhibit suboptimal accuracy irrespective of the basis degree; however, driving the width of the tip panel to zero at a rate faster than the domain average enables improved accuracy to be recovered for the quadratic-strength elements. In all cases considered, higher-order circulation elements exhibit higher accuracy than their lower-order counterparts for the same total degrees of freedom in the solution. It is also found that the discontinuous quadratic elements are more accurate than their continuous counterparts while also being more flexible for geometric representation.
A Contribution to the Discussion of the Theory of Anomie
Authors: Novaković Filip 
Published: March 2023

AbstractThe paper analyses the notion of anomie through various theories presented in the works of classical Greek thinkers up to today’s understanding of this notion. In this regard, the article will touch on some previous understandings of this phenomenon, and the beginnings of modern thought on anomie in the work of Jean-Marie Guyau, and the developed understandings of Robert Merton and Émil Durkheim as the two most prominent authors dealing with this topic. In addition, the attitudes of marginalized writers will be analysed, as well as neglected and underrepresented understandings in criminology and wider science. The purpose of this paper is to find common ground between all previous understandings of the theory of anomie, and to try to find a more specific meaning of the term in order to contribute to the discussion on this topic.
Global Asymptotics of the Sixth Painlevé Equation in Okamoto’s Space
Authors: Heu Viktoria , Joshi Nalini , Radnović Milena 
Published: March 2023

Abstract
We study dynamics of solutions in the initial value space of the sixth Painlevé equation as the independent variable approaches zero. Our main results describe the repeller set, show that the number of poles and zeroes of general solutions is unbounded and that the complex limit set of each solution exists and is compact and connected.
Quantification of time delay between screening and subsequent initiation of contact isolation for carriers of extended-spectrum beta-lactamase (ESBL)–producing Enterobacterales: A post hoc subgroup analysis of the R-GNOSIS WP5 Trial
Authors: Maechler Friederike , Schwab Frank , Hansen Sonja , Behnke Michael , Bonten Marc J. , Canton Rafael , Diaz Agero Cristina , Fankhauser Carolina , Harbarth Stephan , Huttner Benedikt D. , Kola Axel , Gastmeier Petra 
Published: March 2023

AbstractObjectives:The aim of this study was to quantify the time delay between screening and initiation of contact isolation for carriers of extended-spectrum beta-lactamase (ESBL)–producing Enterobacterales (ESBL-E).Methods:This study was a secondary analysis of contact isolation periods in a cluster-randomized controlled trial that compared 2 strategies to control ESBL-E (trial no. ISRCTN57648070). Patients admitted to 20 non-ICU wards in Germany, the Netherlands, Spain, and Switzerland were screened for ESBL-E carriage on admission, weekly thereafter, and on discharge. Data collection included the day of sampling, the day the wards were notified of the result, and subsequent ESBL-E isolation days.Results:Between January 2014 and August 2016, 19,122 patients, with a length of stay ≥2 days were included. At least 1 culture was collected for 16,091 patients (84%), with a median duration between the admission day and the day of first sample collection of 2 days (interquartile range [IQR], 1–3). Moreover, 854 (41%) of all 2,078 ESBL-E carriers remained without isolation during their hospital stay. In total, 6,040 ESBL-E days (32% of all ESBL-E days) accrued for patients who were not isolated. Of 2,078 ESBL-E-carriers, 1,478 ESBL-E carriers (71%) had no previous history of ESBL-E carriage. Also, 697 (34%) were placed in contact isolation with a delay of 4 days (IQR, 2–5), accounting for 2,723 nonisolation days (15% of ESBL-E days).Conclusions:Even with extensive surveillance screening, almost one-third of all ESBL-E days were nonisolation days. Limitations in routine culture-based ESBL-E detection impeded timely and exhaustive implementation of targeted contact isolation.
Patient-facing job role is associated with SARS-CoV-2 positivity among healthcare workers in long term care facilities in Minnesota, August–December, 2020
Authors: Bakare R. Adetunji , Mulcahy John F. , Pullen Matthew F. , Demmer Ryan T. , Cox Sara L. , Thurn Julie A. , Galdys Alison L. 
Published: March 2023

AbstractObjective:Healthcare workers (HCWs) in long-term care facilities (LTCFs) are disproportionately affected by severe acute respiratory coronavirus virus 2 (SARS-CoV-2), the virus that causes coronavirus disease 2019 (COVID-19). To characterize factors associated with SARS-CoV-2 positivity among LTCF HCWs, we performed a retrospective cohort study among HCWs in 32 LTCFs in the Minneapolis–St Paul region.Methods:We analyzed the outcome of SARS-CoV-2 polymerase chain reaction (PCR) positivity among LTCF HCWs during weeks 34–52 of 2020. LTCF and HCW-level characteristics, including facility size, facility risk score for resident-HCW contact, and resident-facing job role, were modeled in univariable and multivariable generalized linear regressions to determine their association with SARS-CoV-2 positivity.Results:Between weeks 34 and 52, 440 (20.7%) of 2,130 unique HCWs tested positive for SARS-CoV-2 at least once. In the univariable model, non–resident-facing HCWs had lower odds of infection (odds ratio [OR], 0.50; 95% confidence interval [CI], 0.36–0.70). In the multivariable model, the odds remained lower for non–resident-facing HCW (OR, 0.50; 95% CI, 0.36–0.71), and those in medium- versus low-risk facilities experienced higher odds of testing positive for SARS-CoV-2 (OR, 1.47; 95% CI, 1.08–2.02).Conclusions:Our findings suggest that COVID-19 cases are related to contact between HCW and residents in LTCFs. This association should be considered when formulating infection prevention and control policies to mitigate the spread of SARS-CoV-2 in LTCFs.
ON COHESIVE POWERS OF LINEAR ORDERS
Authors: DIMITROV RUMEN , HARIZANOV VALENTINA , MOROZOV ANDREY , SHAFER PAUL , SOSKOVA ALEXANDRA A. , VATEV STEFAN V. 
Published: March 2023

AbstractCohesive powersof computable structures are effective analogs of ultrapowers, where cohesive sets play the role of ultrafilters. Let$\omega $,$\zeta $, and$\eta $denote the respective order-types of the natural numbers, the integers, and the rationals when thought of as linear orders. We investigate the cohesive powers of computable linear orders, with special emphasis on computable copies of$\omega $. If$\mathcal {L}$is a computable copy of$\omega $that is computably isomorphic to the usual presentation of$\omega $, then every cohesive power of$\mathcal {L}$has order-type$\omega + \zeta \eta $. However, there are computable copies of$\omega $, necessarily not computably isomorphic to the usual presentation, having cohesive powers not elementarily equivalent to$\omega + \zeta \eta $. For example, we show that there is a computable copy of$\omega $with a cohesive power of order-type$\omega + \eta $. Our most general result is that if$X \subseteq \mathbb {N} \setminus \{0\}$is a Boolean combination of$\Sigma _2$sets, thought of as a set of finite order-types, then there is a computable copy of$\omega $with a cohesive power of order-type$\omega + \boldsymbol {\sigma }(X \cup \{\omega + \zeta \eta + \omega ^*\})$, where$\boldsymbol {\sigma }(X \cup \{\omega + \zeta \eta + \omega ^*\})$denotes the shuffle of the order-types inXand the order-type$\omega + \zeta \eta + \omega ^*$. Furthermore, ifXis finite and non-empty, then there is a computable copy of$\omega $with a cohesive power of order-type$\omega + \boldsymbol {\sigma }(X)$.
Too Legit to Quit? Analyzing the Effect of No-Confidence Motions on Cabinet Members’ Instability in Presidential Systems: The Cases of Colombia and Peru
Authors: Bonilla-Aranzales Jhon Kelly 
Published: March 2023

ABSTRACTHow does the execution of horizontal accountability mechanisms affect cabinet members’ instability? This article analyzes distinct features of no-confidence motions (NCMs) in presidential systems, using a mixed-method research design that identifies elements of legislative control mechanisms in Peruvian and Colombian polities. Although the congress in presidential systems rarely approves NCMs, high salience policy shocks trigger their proposal, resulting in the dismissal or resignation of the cabinet member in question. Those results are subtle opportunities for opposition legislators to indicate the incompetence of the incumbent government in particular policy areas. This study contributes to understanding how contextual factors affect the effectiveness of the check and balance principle in presidential systems.
Antimicrobial susceptibility and biofilm forming ability of staphylococci from subclinical buffalo mastitis
Authors: Ürer Ece Koldaş , Aslantaş Özkan , Tek Erhan , Yılmaz Mehmet Ali , Ergün Yaşar 
Published: March 2023

AbstractThe starting objective of this research communication was to determine the prevalence of subclinical mastitis in buffalo in Turkey. We also seeked to isolate and identify staphylococci, determine their antimicrobial susceptibilities and biofilm-forming abilities as well as investigating the presence of biofilm-related genes and microbial surface components recognizing adhesive matrix molecules. A total of 107 (66.9%) staphylococci (28 S. aureus and 79 coagulase-negative staphylococci, CoNS) were isolated from 160 mastitic milk samples collected from 200 lactating water buffalos. The staphylococci were especially resistant to beta-lactams except for cefoxitin but were less resistant to the other antimicrobials that were tested. Based on the Congo red agar method, 92.9% of the S. aureus and 70.9% of the CoNS isolates were positive for biofilm-forming ability, while all S. aureus and 97.5% of CoNS isolates were positive by a microtiter plate analysis. The presence of icaA and icaD genes was not always correlated with biofilm synthesis, and even in the absence of these genes, the isolates were able to synthesize biofilm.