bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Japanese Circular Economy and Sound Material-Cycle Society Policies: Discourse and Policy Analysis
Authors: Arai Risa , Calisto Friant Martin , Vermeulen Walter J. V. 
Published: September 2023

AbstractAlthough the Japanese government is an early adopter of Circular Economy (CE) policies and developed the concept of the Sound Material-Cycle Society in the early 2000s, its CE policies have nonetheless been poorly researched and understood, especially in English academic literature. This article addresses this research gap by answering the following questions: What are the dominant discourses of key stakeholders in Japan regarding CE? And to what extent does the current CE policy in Japan relate to that? Methodologically, this paper conducted a discourse analysis through a mix of policy analysis, media analysis, stakeholder interviews, keyword mining, qualitative content analysis, and analysis of stakeholder presence. Results show that, while CE discourses in Japan are rather diverse, they mostly fall within the Reformist Circular Society discourse type, with some smaller Technocentric Circular Economy and Transformational Circular Society elements. Results also show that businesses and academics were over-represented in policy meetings and the media, compared to NGOs and local government actors, which are more likely to hold transformational circularity discourses. Most circularity discourses in Japan are thus focused on a growth-optimistic narrative that emphasises innovative technologies and lacks a stronger understanding of social justice and planetary boundaries. Based on these findings, this article suggests recommendations, such as revisiting Japanese ecological thinking and Buddhist philosophy, which can inspire degrowth-oriented circularity approaches, as well as encompassing more participation of neglected societal groups in the development and implementation of CE policies and practices. By highlighting the challenges in current CE discourse and implementation in Japan, this study presents implications for a more socially inclusive and ecologically sustainable path towards a circular society.
Evaluating Causal Arctic‐Midlatitude Teleconnections in CMIP6
Authors: Galytska Evgenia , Weigel Katja , Handorf Dörthe , Jaiser Ralf , Köhler Raphael , Runge Jakob , Eyring Veronika 
Published: September 2023

AbstractTo analyze links among key processes that contribute to Arctic‐midlatitude teleconnections we apply causal discovery based on graphical models known as causal graphs. First, we calculate the causal dependencies from observations during 1980–2021. Observations show several robust connections from early to late winter, such as atmospheric blocking within central Asia via the Ural blocking and Siberian High, the North Atlantic Oscillation phase and the polar vortex (PV). The PV is affected by poleward eddy heat flux at 100 hPa, which is also directly connected with the Aleutian Low. We then evaluate climate models participating in the Coupled Model Intercomparison Project Phase 6 (CMIP6) by comparing their causal graphs with those derived from observations. Compared to observations, CMIP6 historical and future simulations do not robustly capture Arctic‐midlatitude teleconnections arising from Arctic sea ice variability. This highlights the role of atmospheric internal variability in modulating the Arctic‐midlatitude teleconnections. However, we find several distinct patterns that are simulated by most of the analyzed climate models. For example, both historical and future model simulations robustly capture observed atmospheric blocking in central Asia. But contrary to observations, model simulations show a robust link between the Arctic temperature and sea ice cover over Barents and Kara seas. The analysis of future changes also reveals that the connection between the Aleutian Low and the poleward eddy heat flux at 100 hPa is expected to become more robust toward the end of the 21st century than in the analyzed past.
Regional‐Scale Heavy Precipitation Over Fujian‐Jiangxi Region in the Late Spring‐Early Summer of 2006 and Its Connection With Baroclinic Wave Packets in the Upper Troposphere
Authors: Ye Dechao , Guan Zhaoyong , Sun Siyuan , Jin Dachao 
Published: September 2023

AbstractThe most serious heavy precipitation in the past 43 years occurred over Fujian‐Jiangxi region from late May to early June of 2006, causing significant economic losses. Using the ERA5 reanalysis database and daily precipitation collected at 2,479 surface meteorological stations in China, the present study investigates the relationship between the heavy precipitation over Fujian‐Jiangxi region in late spring‐early summer of 2006 and baroclinic wave packets in the upper troposphere. Information flow between the two systems has been diagnosed. Results indicate that different from the disturbance source for Meiyu in the middle and lower reaches of the Yangzi River, the disturbance source for this heavy precipitation originated from areas near the Syrian Desert to the north of the Arabian Peninsula and propagated along the northwest‐southeast direction, reaching Fujian‐Jiangxi region 4 days later. This kind of baroclinic wave packets provide the necessary energy for the occurrence and persistence of heavy precipitation. Analysis of wave activity flux vectors indicates that during the heavy precipitation period, disturbance energy was transported from the upstream westerly belt to Fujian‐Jiangxi region almost every day. Obviously, there existed information transfer between the two regions, re‐confirming that the upstream Rossby wave packets affect the Fujian‐Jiangxi precipitation. The above results provide helpful hints for a better understanding of the mechanisms for heavy precipitation in this region and will be helpful for its effective prediction.
Biomarker Records of Environmental Shifts on the Labrador Shelf During the Holocene
Authors: Kolling Henriette , Schneider Ralph , Gross Felix , Hamann Christian , Kienast Markus , Kienast Stephanie , Doering Kristin , Fahl Kirsten , Stein Ruediger 
Published: September 2023

AbstractThe ultimate demise of the Laurentide Ice Sheet (LIS) and the preceding and succeeding oceanographic changes along the western Labrador Sea offer insights critically important to improve climate predictions of expected future climate warming and further melting of the Greenland ice cap. However, while the final disappearance of the LIS during the Holocene is rather well constrained, the response of sea ice during the resulting meltwater events is not fully understood. Here, we present reconstructions of paleoceanographic changes over the past 9.3 Kyr BP on the northwestern Labrador Shelf, with a special focus on the interaction between the final meltwater event around 8.2 Kyr BP and sea ice and phytoplankton productivity (e.g., IP25, HBI III (Z), brassicasterol, dinosterol, biogenic opal, total organic carbon). Our records indicate low sea‐ice cover and high phytoplankton productivity on the Labrador Shelf prior to 8.9 Kyr BP, sea‐ice formation was favored by decreased surface salinities due to the meltwater events from Lake Agassiz‐Ojibway and the Hudson Bay Ice Saddle from 8.55 Kyr BP onwards. For the past ca. 7.5 Kyr BP sea ice is mainly transported to the study area by local ocean currents such as the inner Labrador and Baffin Current. Our findings provide new insights into the response of sea ice to increased meltwater discharge as well as shifts in atmospheric and oceanic circulation.
On the Links Between Ice Nucleation, Cloud Phase, and Climate Sensitivity in CESM2
Authors: McGraw Zachary , Storelvmo Trude , Polvani Lorenzo M. , Hofer Stefan , Shaw Jonah K. , Gettelman Andrew 
Published: September 2023

AbstractIce nucleation in mixed‐phase clouds has been identified as a critical factor in projections of future climate. Here we explore how this process influences climate sensitivity using the Community Earth System Model 2 (CESM2). We find that ice nucleation affects simulated cloud feedbacks over most regions and levels of the troposphere, not just extratropical low clouds. However, with present‐day global mean cloud phase adjusted to replicate satellite retrievals, similar total cloud feedback is attained whether ice nucleation is simulated as aerosol‐sensitive, insensitive, or absent. These model experiments all result in a strongly positive total cloud feedback, as in the default CESM2. A microphysics update from CESM1 to CESM2 had substantially weakened ice nucleation, due partly to a model issue. Our findings indicate that this update reduced global cloud phase bias, with CESM2's high climate sensitivity reflecting improved mixed‐phase cloud representation.
Percolation of Low‐Dimensional Water at Crystalline Interfaces Mediates Fluid Migration in Subducting Slabs
Authors: Chen Meng , Zhu Runliang , Zhu Jianxi , He Hongping 
Published: September 2023

AbstractDuring subduction, metamorphic dehydration reactions in the downgoing slab release fluids, generating fluid overpressure. It has been suggested that fluid is driven to flow upward by buoyancy, but a sufficiently high permeability allowing formation of a fluid percolation network is required. Traditionally, fluid percolation has been identified based on the textural equilibrium assumption by measuring the dihedral angle at the triple junction of grains. According to this theory, grain boundaries generally cannot be infiltrated by fluid, and only the grain edge can form a fluid flow channel. We argue that this theory is insufficient because we have found that water from fluid can be adsorbed into the crystalline interface, that is, a layered mineral interlayer, a crack, or a grain boundary. The high pressure in a subducting slab drives water adsorption into the crystalline interface, forming a low‐dimensional fluidic phase, and thus fluid percolation is achieved. Because water adsorbed in the interface is fluidic, water diffusion drives fluid transport in the subducting slab. Due to water adsorption, fluid overpressure at the dehydration front may release, so that dehydration embrittlement may be excluded. Stable water adsorption in the subduction‐slab conditions is determined here by combining molecular dynamics simulations and thermodynamic calculations. Analysis based on simulations shows that water adsorption requires crystalline surfaces which do not form hydrogen bonds well.
Emission Factors for Crop Residue and Prescribed Fires in the Eastern US During FIREX‐AQ
Authors: Travis Katherine R. , Crawford James. H. , Soja Amber J. , Gargulinski Emily M. , Moore Richard H. , Wiggins Elizabeth B. , Diskin Glenn S. , DiGangi Joshua P. , Nowak John B. , Halliday Hannah , Yokelson Robert J. , McCarty Jessica L. , Simpson Isobel J. , Blake Donald R. , Meinardi Simone , Hornbrook Rebecca S. , Apel Eric C. , Hills Alan J. , Warneke Carsten , Coggon Matthew M. , Rollins Andrew W. , Gilman Jessica B. , Womack Caroline C. , Robinson Michael A. , Katich Joseph M. , Peischl Jeff , Gkatzelis Georgios I. , Bourgeois Ilann , Rickly Pamela S. , Lamplugh Aaron , Dibb Jack E. , Jimenez Jose L. , Campuzano‐Jost Pedro , Day Douglas A. , Guo Hongyu , Pagonis Demetrios , Wennberg Paul O. , Crounse John D. , Xu Lu , Hanisco Thomas F. , Wolfe Glenn M. , Liao Jin , St. Clair Jason M. , Nault Benjamin A. , Fried Alan , Perring Anne E. 
Published: September 2023

AbstractAgricultural and prescribed burning activities emit large amounts of trace gases and aerosols on regional to global scales. We present a compilation of emission factors (EFs) and emission ratios from the eastern portion of the Fire Influence on Regional to Global Environments and Air Quality (FIREX‐AQ) campaign in 2019 in the United States, which sampled burning of crop residues and other prescribed fire fuels. FIREX‐AQ provided comprehensive chemical characterization of 53 crop residue and 22 prescribed fires. Crop residues burned at different modified combustion efficiencies (MCE), with corn residue burning at higher MCE than other fuel types. Prescribed fires burned at lower MCE (<0.90) which is typical, while grasslands burned at lower MCE (0.90) than normally observed due to moist, green, growing season fuels. Most non‐methane volatile organic compounds (NMVOCs) were significantly anticorrelated with MCE except for ethanol and NMVOCs that were measured with less certainty. We identified 23 species where crop residue fires differed by more than 50% from prescribed fires at the same MCE. Crop residue EFs were greater for species related to agricultural chemical use and fuel composition as well as oxygenated NMVOCs possibly due to the presence of metals such as potassium. Prescribed EFs were greater for monoterpenes (5×). FIREX‐AQ crop residue average EFs generally agreed with the previous agricultural fire study in the US but had large disagreements with global compilations. FIREX‐AQ observations show the importance of regionally‐specific and fuel‐specific EFs as first steps to reduce uncertainty in modeling the air quality impacts of fire emissions.
The mediating role of obesity on the prospective association between urinary sucrose and diabetes incidence in a sub-cohort of the EPIC-Norfolk
Authors: Lang Alexander , Kuss Oliver , Filla Tim , Kuhnle Gunter , Schlesinger Sabrina 
Published: September 2023

Abstract
Background/objectives
Findings from epidemiological studies showed controversial findings between dietary sugar intake and the development of diabetes. Most of these studies assessed dietary sugar intake by self-reports which might be prone to bias. Urinary sucrose, an objective biomarker of sucrose intake, might provide better insights into this association. Thus, the aim of this study was to investigate the associations between sucrose intake, measured via self-reports and urinary sucrose, with incident diabetes and to detect the impact of obesity on this association.

Subjects/methods
Data of a sub-group (n = 2996) from the prospective EPIC-Norfolk cohort were investigated. Sucrose intake was assessed by self-reports (validated food frequency questionnaire (FFQ) and 7-day diet diaries (7DD)) and as an objective urinary sucrose biomarker. Cox proportional hazard models were conducted to calculate hazard ratios (HRs) and 95% confidence intervals (CI) for the associations between urinary and dietary sucrose intake and incident diabetes. Mediation analysis was performed to investigate the mediated percentage of body mass index (BMI) and waist circumference (WC) on this association.

Results
The mean age of the participants was 60.6 ± 9.5 years and 53% were women. After a mean follow-up of 11.2 ± 2.9 years, 97 participants developed diabetes. Findings suggested inverse associations regarding incident diabetes for self-reported sucrose intake per 50 g/d via 7DD [HR: 0.63 (95% CI: 0.43, 0.91)], and a tendency via FFQ [HR: 0.81 (95% CI: 0.46, 1.42)]. Urinary sucrose indicated a positive association with incident diabetes for each increase of 100 µM [HR: 1.14 (95% CI: 0.95, 1.36)]. The proportion mediated of BMI and WC for this association was 16 and 22%.

Conclusions
These findings indicate that sucrose measured as objective urinary biomarker points to a positive association with incident diabetes. BMI might partly mediate this association. However, to obtain more precise results, more studies are warranted that consider this objective biomarker.
N7-methylguanosine methylation of tRNAs regulates survival to stress in cancer
Authors: García-Vílchez Raquel , Añazco-Guenkova Ana M. , López Judith , Dietmann Sabine , Tomé Mercedes , Jimeno Sonia , Azkargorta Mikel , Elortza Félix , Bárcena Laura , Gonzalez-Lopez Monika , Aransay Ana M. , Sánchez-Martín Manuel A. , Huertas Pablo , Durán Raúl V. , Blanco Sandra 
Published: September 2023

AbstractTumour progression and therapy tolerance are highly regulated and complex processes largely dependent on the plasticity of cancer cells and their capacity to respond to stress. The higher plasticity of cancer cells highlights the need for identifying targetable molecular pathways that challenge cancer cell survival. Here, we show that N7-guanosine methylation (m7G) of tRNAs, mediated by METTL1, regulates survival to stress conditions in cancer cells. Mechanistically, we find that m7G in tRNAs protects them from stress-induced cleavage and processing into 5’ tRNA fragments. Our analyses reveal that the loss of tRNA m7G methylation activates stress response pathways, sensitising cancer cells to stress. Furthermore, we find that the loss of METTL1 reduces tumour growth and increases cytotoxic stress in vivo. Our study uncovers the role of m7G methylation of tRNAs in stress responses and highlights the potential of targeting METTL1 to sensitise cancer cells to chemotherapy.
Impact of intraspecific variation in insect microbiomes on host phenotype and evolution
Authors: Lange Claudia , Boyer Stéphane , Bezemer T Martijn , Lefort Marie-Caroline , Dhami Manpreet K , Biggs Eva , Groenteman Ronny , Fowler Simon V , Paynter Quentin , Verdecia Mogena Arletys M , Kaltenpoth Martin 
Published: September 2023

Abstract
Microbes can be an important source of phenotypic plasticity in insects. Insect physiology, behaviour, and ecology are influenced by individual variation in the microbial communities held within the insect gut, reproductive organs, bacteriome, and other tissues. It is becoming increasingly clear how important the insect microbiome is for insect fitness, expansion into novel ecological niches, and novel environments. These investigations have garnered heightened interest recently, yet a comprehensive understanding of how intraspecific variation in the assembly and function of these insect-associated microbial communities can shape the plasticity of insects is still lacking. Most research focuses on the core microbiome associated with a species of interest and ignores intraspecific variation. We argue that microbiome variation among insects can be an important driver of evolution, and we provide examples showing how such variation can influence fitness and health of insects, insect invasions, their persistence in new environments, and their responses to global environmental changes.
Brain mediators of biased social learning of self-perception in social anxiety disorder
Authors: Koban Leonie , Andrews-Hanna Jessica R. , Ives Lindsay , Wager Tor D. , Arch Joanna J. 
Published: September 2023

AbstractSocial anxiety disorder (SAD) is characterized by an excessive fear of social evaluation and a persistently negative view of the self. Here we test the hypothesis that negative biases in brain responses and in social learning of self-related information contribute to the negative self-image and low self-esteem characteristic of SAD. Adult participants diagnosed with social anxiety (N = 21) and matched controls (N = 23) rated their performance and received social feedback following a stressful public speaking task. We investigated how positive versus negative social feedback altered self-evaluation and state self-esteem and used functional Magnetic Resonance Imaging (fMRI) to characterize brain responses to positive versus negative feedback. Compared to controls, participants with SAD updated their self-evaluation and state self-esteem significantly more based on negative compared to positive social feedback. Responses in the frontoparietal network correlated with and mirrored these behavioral effects, with greater responses to positive than negative feedback in non-anxious controls but not in participants with SAD. Responses to social feedback in the anterior insula and other areas mediated the effects of negative versus positive feedback on changes in self-evaluation. In non-anxious participants, frontoparietal brain areas may contribute to a positive social learning bias. In SAD, frontoparietal areas are less recruited overall and less attuned to positive feedback, possibly reflecting differences in attention allocation and cognitive regulation. More negatively biased brain responses and social learning could contribute to maintaining a negative self-image in SAD and other internalizing disorders, thereby offering important new targets for interventions.
Ufmylation on UFBP1 alleviates non-alcoholic fatty liver disease by modulating hepatic endoplasmic reticulum stress
Authors: Mao Ziming , Ma Xiaowen , Jing Yu , Shen Minyan , Ma Xirui , Zhu Jing , Liu Huifang , Zhang Guangya , Chen Fengling 
Published: September 2023

AbstractNon-alcoholic fatty liver disease (NAFLD) is the most common liver disease characterized by lipid accumulation and endoplasmic reticulum (ER) stress, while effective therapies targeting the specific characteristics of NAFLD are limited. Ufmylation is a newly found post-translational modification process that involves the attachment of the Ubiquitin-fold modifier 1 (UFM1) protein to its substrates via ufmylation modification system. Ufmylation regulates ER stress via modifying UFM1 binding protein 1 (UFBP1), suggesting a potential role for ufmylation in NAFLD pathogenesis. However, the precise role of ufmylation in NAFLD remains unclear. Herein, we aim to elucidate the impact of ufmylation on UFBP1 in NAFLD and explore the underlying mechanisms involved. We observed increased expression of UFM1-conjugated proteins and ufmylation modification system components in livers with steatosis derived from NAFLD patients and NAFLD models. Upregulation of ufmylation on hepatic proteins appeared to be an adaptive response to hepatic ER stress in NAFLD. In vitro, knocking down UFBP1 resulted in increased lipid accumulation and lipogenesis in hepatocytes treated with free fatty acids (FFA), which could be rescued by wild-type UFBP1 (WT UFBP1) but not by a mutant form of UFBP1 lacking the main ufmylation site lys267 (UFBP1 K267R). In vivo, ufmylation on UFBP1 ameliorated obesity, hepatic steatosis, hepatic lipogenesis, dyslipidemia, insulin resistance and liver damage in mice with NAFLD induced by a high fat diet (HFD). We also demonstrated that the downregulation of UFBP1 induced ER stress, whereas the reintroduction or overexpression of UFBP1 alleviated ER stress in a manner dependent on ufmylation in NAFLD. This mechanism could be responsible for the amelioration of aberrant hepatic lipogenesis and insulin resistance in NAFLD. Our data reveal a protective role of ufmylation on UFBP1 against NAFLD and offer a specific target for NAFLD treatment.
BCL2L13 promotes mitophagy through DNM1L-mediated mitochondrial fission in glioblastoma
Authors: Wang Jiwei , Chen Anbin , Xue Zhiwei , Liu Junzhi , He Ying , Liu Guowei , Zhao Zhimin , Li Wenjie , Zhang Qing , Chen Anjing , Wang Jian , Li Xingang , Wang Xinyu , Huang Bin 
Published: September 2023

AbstractThere is an urgent need for novel diagnostic and therapeutic strategies for patients with Glioblastoma multiforme (GBM). Previous studies have shown that BCL2 like 13 (BCL2L13) is a member of the BCL2 family regulating cell growth and apoptosis in different types of tumors. However, the clinical significance, biological role, and potential mechanism in GBM remain unexplored. In this study, we showed that BCL2L13 expression is significantly upregulated in GBM cell lines and clinical GBM tissue samples. Mechanistically, BCL2L13 targeted DNM1L at the Ser616 site, leading to mitochondrial fission and high mitophagy flux. Functionally, these alterations significantly promoted the proliferation and invasion of GBM cells both in vitro and in vivo. Overall, our findings demonstrated that BCL2L13 plays a significant role in promoting mitophagy via DNM1L-mediated mitochondrial fission in GBM. Therefore, the regulation and biological function of BCL2L13 render it a candidate molecular target for treating GBM.