bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of obesity under different metabolic status with adverse outcomes in patients with chronic myeloid leukemia: A retrospective cohort study
Authors: Dong Yingchun , Cheng Yiping , Feng Xiaoshan , Yuan Zinuo , Dong Hang , Zhang Yue , Han Junming , Wu Yafei , Wang Zhixiang , Zhong Xia , Fan Xiude , Zhao Jiajun 
Published: April 2023

AbstractBackgroundLittle is known about the association between abnormal metabolic obesity states and the outcomes of chronic myeloid leukemia (CML), especially in patients with obesity with different metabolic status. Here, we used the Nationwide Readmissions Database to assess the effects of metabolically defined obesity on adverse outcomes of CML.MethodsOf the 35 460 557 (weighted) patients, we included 7931 adults with discharge diagnoses of CML from January 1, 2018 to June 30, 2018. The study population was observed until December 31, 2018 and divided into four groups based on body mass index and metabolic status. The primary outcome was the adverse outcomes of CML, including nonremission (NR)/relapse and severe mortality risk. Multivariate logistic regression analysis was performed to analyze data.ResultsMetabolically unhealthy normal weight and metabolically unhealthy obesity were all risk factors for adverse outcomes of CML compared with metabolically healthy normal weight (all p < 0.01), and a significant difference was not found in the metabolically healthy obese. Female patients with metabolically unhealthy normal weight and metabolically unhealthy obesity had 1.23‐fold and 1.40‐fold increased NR/relapse risk, while male patients did not have this risk. Moreover, patients with a higher number of metabolic risk factors or with dyslipidemia were at higher risk of adverse outcomes, regardless of obesity status.ConclusionsMetabolic abnormalities were associated with adverse outcomes in patients with CML, irrespective of obesity status. Future treatment of patients with CML should consider the effects of obesity on their adverse outcomes under different metabolic status, especially in female patients.
Erythema nodosum caused by goserelin acetate sustained‐release: Case report and literature review
Authors: Meng Fanyu , Su Rong , Ling Li , Yan Weitian , Du Shiyu , Peng Jiangyun , Liu Weichao 
Published: April 2023

AbstractGoserelin acetate is a gonadotropin‐releasing hormone analog that is commonly used in patients with prostate cancer, endometriosis, and precocious puberty. The side effects of the drug include allergic rash, flushing, excessive sweating, skin swelling at the injection site, sexual dysfunction, erectile dysfunction, and menopausal symptoms. However, erythema nodosum has so far not been reported. In this paper, we have presented the case of erythema nodosum caused by goserelin acetate and a review of the literature on its adverse effects, thus providing useful insights into clinical management and medication safety.
The post‐registration monitoring of glyphosate‐treated plants using anecic earthworms
Authors: Stroud Jacqueline L. , Halsey Kirstie 
Published: April 2023

AbstractGlyphosate N‐(phosphonomethyl) glycine is a widely‐used herbicide in agriculture. The anecic earthworm, Lumbricus terrestris feeds and forages for surface plant materials meaning that this species has a unique and direct exposure to agrichemicals. At the recommended product rates, significantly (F1,44 = 8.67, p = .005) higher numbers of L. terrestris middens were found in the glyphosate treated areas of an arable crop field. Laboratory feeding assays using field aged plant materials indicated that previous glyphosate treatment was a statistically significant factor affecting earthworm L. terrestris biomass (F1,12 = 5.75, p = .03). Negligible glyphosate residues were detectable, and the field aged plant materials were encrusted with fungal hyphae. This suggests that glyphosate influences the colonisation of plant material by a litter‐fungus complex which improves the food quality to earthworms. Concentrations of epoxiconazole, a fungicide, were detected in some plant materials and may influence overall food quality to earthworms. Glyphosate treatment on fresh volunteer plant leaves (unwanted crop seedlings) was not a statistically significant factor affecting earthworm L. terrestris biomass (F1,6 = 0.16, p = .92). These results indicate fungal communities influence feeding behaviours, and plant materials are a direct source of agrichemicals to anecic earthworms.
Ordinance influences individuals' perceptions towards prospects of social circumstance but not the status quo: An experimental field study on sexual minorities issues in Japan
Authors: Miyajima Takeru , Nakawake Yo , Meng Xianwei , Sudo Ryunosuke 
Published: April 2023

AbstractScientific evidence shows that institutional decisions can change individuals' private attitudes towards relevant issues. However, little is known about their effect on individuals' perceptions of social norms. This intriguing question has gained the attention of scholars. Nonetheless, the findings are primarily observed only in samples of the Western, Educated, Industrialised, Rich, and Democratic countries, leading to doubts about their generalisability. This study experimentally tested residents' (N = 411) reactions to the new Tokyo ordinance prohibiting discrimination against sexual minorities enacted on October 5, 2018, and tested whether it dispelled self–other discrepancies regarding tolerance towards sexual minorities (i.e., pluralistic ignorance). The results showed that exposure to information about enactment increased future perceptions of support and understanding of sexual minorities. By contrast, private attitudes, perceptions of current social norms, and willingness to speak out did not change. Willingness to speak out was indirectly enhanced through increased perceptions of gaining future support. Furthermore, Tokyo residents overestimated other residents' negative attitudes towards sexual minorities. However, even when informed of the new ordinance, this self–other discrepancy in intolerance towards sexual minorities was not corrected. These findings suggest that institutional decisions can shape the perception of social norm change in the future beyond Western countries.
Comparison of decline in renal function between patients with chronic hepatitis B with or without antiviral therapy
Authors: Lee Jae Seung , Jung Chan‐Young , Lee Jung Il , Ahn Sang Hoon , Kim Beom Seok , Kim Seung Up 
Published: April 2023

SummaryBackground and AimsRenal function can deteriorate in patients with chronic hepatitis B (CHB). We compared the risk of renal function decline between patients with untreated and treated CHB receiving antiviral therapy.MethodsThis retrospective study included 1061 untreated CHB patients, and 366 on tenofovir alafenamide (TAF), 190 on besifovir dipivoxil maleate (BSV), and 2029 on entecavir (ETV). The primary outcome was renal function decline, a ≥ one‐stage increase in chronic kidney disease for ≥3 consecutive months.ResultsThe incidence and risk of renal function decline were significantly higher in the 1:1 propensity score‐matched treated group (588 pairs) than in the untreated (2.7 per 1000 person–years [PYs] vs. 1.3 per 1000 PYs, adjusted hazard ratio [aHR] = 2.29, all p < 0.001). The matched TAF group (222 pairs) showed a similar risk for the primary outcome (aHR = 1.89, p = 0.107) despite a significantly higher incidence thereof, compared to the untreated (3.9 vs. 1.9 per 1000 PYs, p = 0.042). The matched BSV and untreated groups (107 pairs) showed no significant differences in the incidence and risk. However, ETV users (541 pairs) carried a significantly higher outcome incidence and risk than the matched untreated (3.6 vs. 1.1 per 1000 PYs, aHR = 1.05, all p < 0.001). Compared to each matched untreated group, changes in the estimated glomerular filtration rate over time were greater in the ETV group (p = 0.010), despite being similar in the TAF (p = 0.073) and BSV groups (p = 0.926).ConclusionsCompared with untreated patients, TAF or BSV users showed similar risk, whereas ETV users showed a higher risk of renal function decline.
Self‐rated eyesight among healthy older Australians: Baseline results of the ASPREE Longitudinal Study of Older Persons
Authors: McGuinness Myra B. , Robman Liubov D. , McNeil John J. , Tran Cammie , Woods Robyn L. , Owen Alice J. , Pham Thao , Guymer Robyn H. 
Published: April 2023

AbstractBackgroundWe aimed to describe the self‐reported level of eyesight amongst a cohort of relatively healthy older Australian adults, and to investigate associations between poorer self‐rated eyesight and demographic, health, and functional characteristicsMethodsThe ASPirin in Reducing Events in the Elderly (ASPREE) Longitudinal Study of Older Persons (ALSOP) study was embedded in a multisite trial which recruited independently living Australians from general practices (2010–2014). Self‐rated eyesight was recorded on a paper‐based questionnaire as Excellent, Good, Fair, Poor, Very poor, or Completely blind at the baseline study waveResultsData from 14 592 participants (aged 70–95 years, 54.61% female) were included in this cross‐sectional analysis. Eighty percent of participants reported excellent or good eyesight (n = 11 677). People with complete blindness were precluded from enrolling but 299 participants (2.0%) reported poor or very poor eyesight, and 2616 rated their eyesight as fair (17.9%). Lower levels of eyesight were associated with being older, female, fewer years of formal education, a primary language other than English, smoking, and self‐reported macular degeneration, glaucoma, retinopathy, cataracts, and hearing problems (each p ≤ 0.021). People with lower levels of eyesight had a higher number of falls, frailty characteristics, and depressive symptoms, and lower mental and physical health functioning scores (each p < 0.001)ConclusionsWhilst most of these healthy older Australians reported good or excellent eyesight, a notable minority reported poor or very poor eyesight, and this was associated with a range of poorer health measures. These findings support the need for additional resources to prevent vision loss and associated sequelae
Oral candidiasis in patients hospitalised in the intensive care unit: Diagnosis through clinical and cytopathological examinations
Authors: dos Santos Freire Fabiane Marques , Marques Letícia Côgo , da Silva Natasha Camargo , Cunha Karin Soares , Conde Danielle Castex , Milagres Adrianna , Gonçalves Lúcio Souza , Junior Arley Silva 
Published: April 2023

AbstractObjectiveTo evaluate the prevalence and clinical aspects of oral candidiasis in patients hospitalised in the intensive care unit.MethodsThis is a longitudinal and prospective study that included 48 participants hospitalised in the intensive care unit. Sociodemographic data, presence of systemic disorders, use of medications, laboratory tests, cause of hospital admission, type of breathing, and length of hospital stay were obtained from medical records. Oral clinical inspection and cytopathological examinations were performed on all participants. The diagnosis of clinical candidiasis was based on the presence of clinical alterations together with positive cytopathological examination results. The diagnosis of subclinical candidiasis was based on the absence of clinical lesions and a positive cytopathological examination. The absence of oral candidiasis was considered when the participant did not present oral lesions and had a negative cytopathological examination.ResultsClinical candidiasis was present in 18.8% of the 48 participants, and 45.8% of them had the subclinical form. Levels of urea (P = 0.005), creatinine (P = 0.009), haemoglobin (P = 0.009), haematocrit (P = 0.011), bands (P = 0.024), international normalised ratio (INR; P = 0.034), types of breathing (P = 0.017), length of hospital stay (P = 0.037), and outcome (P = 0.014) demonstrated statistically significant differences between the groups with and without oral candidiasis.ConclusionsClinical and subclinical forms of oral candidiasis are frequent in intensive care unit patients. Levels of urea, creatinine, haemoglobin, haematocrit, bands, INR, type of breathing, length of hospital stay, and outcome can be associated with the presence of candidiasis.
Gender differences on healthcare accessibility and outcomes of a electronic inter‐clinician consultation program at the cardiology department in a Galician Health Area
Authors: Mazón‐Ramos Pilar , Rey‐Aldana Daniel , Garcia‐Vega David , Portela‐Romero Manuel , Rodríguez‐Mañero Moisés , Lage‐Fernández Ricardo , Cinza‐Sanjurjo Sergio , González‐Juanatey José R. 
Published: April 2023

AbstractAimsTo assess the longer‐term results (hospital admissions and mortality) in women versus men referred to a cardiology department from primary care using an e‐consultation in our outpatient care programme.MethodsWe selected 61,306 patients (30,312 women and 30,994 men) who visited the cardiology service at least once between 2010 and 2021: 69.1% (19,997 women and 20,462 men) were attended in e‐consultation (from 2013 to 2021) and 30.9% (8920 women and 9136 men) in in‐person consultations (from 2010 to 2012) without gender differences in the proportion of patients attended in each period. Using an interrupted time series regression model, we analysed the impact of incorporating e‐consultation into the healthcare model and evaluated the elapsed time to cardiology care, heart failure (HF), cardiovascular (CV), and all‐cause hospital admissions and mortality during the one‐year after cardiology consultation.ResultsThe introduction of e‐consultation substantially decreased waiting times to cardiology care; during the in‐person consultation period, the mean delay for cardiology care was 57.9 (24.8) days in men and 55.8 (22.8) days in women. During the e‐consultation period, the waiting time to cardiology care was markedly reduced to 9.41 (4.02) days in men and 9.46 (4.18) in women. After e‐consultation implantation, there was a significant reduction in the 1‐year rate of hospital admissions and mortality, both in women and men iRR [IC 95%]: 0.95 [0.93–0.96] for HF, 0.90 [0.89–0.91] for CV and 0.70 [0.69–0.71] for all‐cause hospitalization; and 0.93 [0.92–0.95] for HF, 0.86 [0.86–0.87] for CV and 0.88 [0.87–0.89] for all‐cause mortality in women; and 0.91 [0.89–0.92] for HF, 0.90 [0.89–0.91] for CV and 0.72 [0.71–0.73] for all‐cause hospitalization; and 0.96 [0.93–0.97] for HF, 0.87 [95% CI: 0.86–0.87] for CV and 0.87 [0.86–0.87] for all‐cause mortality, in men.ConclusionCompared with the in‐person consultation period, an outpatient care programme that includes an e‐consultation significantly reduced waiting time to cardiology care and was safe, with a lower rate of hospital admissions and mortality in the first year, without significative gender differences.
Granite rock towers shaped by mesh‐like joint sets, which formed in the shallower portion of a granite body during cooling at depth
Authors: Chigira Masahiro , Kato Hironori 
Published: April 2023

AbstractGranite is fractured according to the stress state during the cooling stage, providing predispositions for later topographic evolution. This study clarified that triangular mesh‐like joints can be made during granite cooling and that they can become the structural causes for the formation of rock towers and corestones on the ground. Tengu rock, which consists of rock towers and granite corestones in Hiroshima, was investigated using an unmanned air vehicle. The rock towers were shaped by high‐angle mesh‐like joints, which were likely made during the cooling of the granite and are dominated by three joint sets. All the joint sets have sharp planar surfaces, which suggests that they are brittle fractures. One joint set is cut by the other two joint sets, frequently accompanies aplite and quartz veins and is developed in the whole exposed granite; this set likely formed first during cooling and then was penetrated by aplite from depth. The other two joint sets are high‐angle conjugate joint sets, are limited to the shallower portion of the granite pluton and do not extend deeper, which strongly suggests that they formed in a rapidly cooled shallower portion of the pluton, probably near its roof. These three joint sets form rock columns with parallelogram cross‐sections, in which incipient corestones were made. Subsurface weathering along the joints and subsequent exhumation of the weathering products formed the present rock towers and corestones only in the shallower portion of the granite.
Memories that last: Dynamics of memory T cells throughout the body
Authors: Derksen Lyanne Y. , Tesselaar Kiki , Borghans José A. M. 
Published: April 2023

SummaryMemory T cells form an essential part of immunological memory, which can last for years or even a lifetime. Much experimental work has shown that the individual cells that make up the memory T‐cell pool are in fact relatively short‐lived. Memory T cells isolated from the blood of humans, or the lymph nodes and spleen of mice, live about 5–10 fold shorter than naive T cells, and much shorter than the immunological memory they convey. The commonly accepted view is, therefore, that long‐term T‐cell memory is maintained dynamically rather than by long‐lived cells. This view is largely based on memory T cells in the circulation, identified using rather broad phenotypic markers, and on research in mice living in overly clean conditions. We wondered to what extent there may be heterogeneity in the dynamics and lifespans of memory T cells. We here review what is currently known about the dynamics of memory T cells in different memory subsets, locations in the body and conditions of microbial exposure, and discuss how this may be related to immunometabolism and how this knowledge can be used in various clinical settings.
Body image, interoceptive awareness, depression and eating disorder symptoms: Within‐group variability among sexual minority women
Authors: Tebbe Elliot A. , Simone Melissa , Greene Madelyne Z. 
Published: April 2023

AbstractThis study investigates within‐group differences in body image concerns among sexual minority women and their related association with eating disorders and depression. Cross‐sectional data were collected in 2017 and analysed in 2020 from 201 sexual minority women in the United States. Latent profile analyses and post hoc comparison analyses were conducted to investigate within‐group variability in body image concerns and to understand their impact on depressive and eating disorder symptoms. Results suggested that a 5‐class solution best fit the data, with five distinct profiles emerging in patterns of interoceptive awareness, sociocultural attitudes toward appearance, body shame, body surveillance and appearance anxiety. Significant differences in mean scores of depressive and eating disorder symptomatology emerged among the profiles; groups that reported low interoceptive awareness and high body image concerns experienced greater levels of eating disorder and depressive symptoms, compared to groups with average or higher levels of interoceptive awareness and average or lower body image concerns. Results underscore the significant within‐group variability that exists for sexual minority women with regard to the prevalence of body image concerns, depressive symptoms and eating disorder symptoms. Efforts that aim to increase interoceptive awareness (for example, mindfulness) alongside strategies aimed at addressing negative body image concerns may be particularly effective avenues for future depression and eating disorder prevention in this diverse group. Our reporting adheres to the STROBE research reporting checklist.
“I thought it would just be, like, older men in white coats”: A qualitative exploration of first encounters with mental health services
Authors: Goodwin John , Cummins John , O'Malley Maria 
Published: April 2023

AbstractIndividuals whose mental health is becoming a concern may not receive the care they require. Although efforts have been made to reduce barriers to accessing services, including stigma reduction campaigns and healthcare practitioner training, there remains a lack of understanding of individual perspectives regarding help‐seeking behaviour. The aim of this study was to explore people's first experiences accessing mental health services. A qualitative descriptive approach was adopted. Interviews were conducted with eight service users. Data were analysed using reflexive thematic analysis. The COREQ checklist guided this study (Tong et al., 2007, International Journal for Quality in Health Care, 19, 349). Three themes were identified: learning to navigate an unfamiliar system, making sense of mental health services, and promoting a positive image for those in need of care. Uncertainty about mental health services and stigmatizing images could be mitigated by developing positive media‐based interventions. Systemic barriers need to be addressed and services need to be better resourced to ensure the benefits of early intervention are available to those experiencing mental health challenges. To encourage people to access services earlier, services need to be promoted in a positive way.
Analysing the aspects of sustainable consumption and impact of product quality, perceived value, and trust on the green product consumption
Authors: Thakur Meenakshi , Madhu  , Kumar Rakesh 
Published: April 2023

AbstractIn the current scenario, consumers’ approach and decision to go for green products is a result of the environmental challenges faced by society at large. The benefits of using green products are well known in society. Green products are user‐friendly and contribute towards sustainable consumption. This paper investigates the effect of varied aspects of sustainable consumption on the consumption of green products. The empirical evidence focused on product quality, perceived value and trust as significant factors. A survey of 350 Indian consumers using green products was used to perform a descriptive quantitative study. The proposed hypotheses were tested using regression analysis. Findings revealed that product quality, perceived value and trust all had an impact on green product consumption. The study has found that consumers prefer green products because of their attribute of maintaining the natural environment. Therefore, based on the associated quality of green products, the relative value obtained and developed trust, an increase in green‐concept‐based product consumption can be achieved. This study recommends that future research should focus on further micro‐level aspects that constitute these important factors, namely product quality and perceived value, and trust all having a vital effect on green product consumption.
First report on the life history of the marine amphipod Ceradocus mizani and its implication for aquaculture
Authors: Shahin Sharif , Okomoda Victor Tosin , Ishak Sairatul Dahlianis , Waiho Khor , Fazhan Hanafiah , Azra Mohamad Nor , Azman B. Abdul Rahim , Wongkamhaeng Koraon , Abualreesh Muyassar H. , Rasdi Nadiah W. , Ma Hongyu , Ikhwanuddin Mhd 
Published: April 2023

AbstractThe search for alternative live feed for aquaculture stocks has inspired research into marine amphipods. In this study, the life history of Ceradocus mizani was evaluated to better understand how this amphipod might be used in aquaculture as an alternative feed. The amphipods did not display copulatory behavior during the study period. The females were multivoltine and attained sexual maturity on average in 23.6 days at a mean length of 4.64 mm. The incubation period lasted 8.8 days, and the mean number of juveniles produced per brood during that incubation period was relatively low (7.58). Females produced a mean of 5.2 consecutive broods and 39.4 total juveniles over the life span. (i.e., 0.33 juveniles/day). Sex ratio was female skewed (1.55:1). Female size and the number of juveniles produced per brood were positively correlated (R2 = 0.63). The mean life span for females and males was 119.4 and 91.2 days, respectively. Mean maximum length was 9.26 mm for males and 8.18 mm for females. This is the first account of the life history of C. mizani and forms the basis for future studies of this marine amphipod.