bluuebunny/crossref_metadata_2025_split huggingface dataset:
Metformin counters oxidative stress and mitigates adverse effects of radiation exposure: An overview
Authors: Karmanova Ekaterina , Chernikov Anatoly , Usacheva Anna , Ivanov Vladimir , Bruskov Vadim 
Published: February 2023

AbstractMetformin (1,1‐dimethylbiguanidine hydrochloride) (MF) is a drug that has long been in use for the treatment of type 2 diabetes mellitus and recently is coming into use in the radiation therapy of cancer and other conditions. Exposure to ionizing radiation disturbs the redox homeostasis of cells and causes damage to proteins, membranes, and mitochondria, destroying a number of biological processes. After irradiation, MF activates cellular antioxidant and repair systems by signaling to eliminate the harmful consequences of disruption of redox homeostasis. The use of MF in the treatment of the negative effects of irradiation has great potential in medical patients after radiotherapy and in victims of nuclear accidents or radiologic terrorism.
Predictors of online health information seeking behaviour of non‐medical undergraduate students might vary
Authors: Adegbilero‐Iwari Oluwaseun Eniola , Oluwadare Tunrayo , Adegbilero‐Iwari Idowu 
Published: February 2023

AbstractBackgroundAs more people across Generations X, Y, and Z continue to use the Internet meet their information needs, this study assesses the characteristics influencing the online health information seeking behaviour (OHISB) of non‐medical university students. Previous studies on the subject in Nigeria have largely assessed the concept of OHISB among university students without examining the determinants of such behaviour.ObjectiveTo determine the predictors of OHISB among non‐medical undergraduate students of a Nigerian private university.MethodsAdopting a cross‐sectional research design, the study utilized a semi‐structured questionnaire administered via Google forms. Some 361 non‐medical undergraduate students were recruited purposively with a response rate of 84.2%. The questionnaire obtained data on students' socio‐demographics, Internet usage, and OHISB.ResultsPresence of a chronic condition, gender, and college showed significant associations with students' OHISB. ‘Mothers' occupation’ and ‘prior experience’ became significant predictors of students' OHISB.DiscussionThe results align with studies that stressed that chronically ill persons would search for health information on the internet and that presence of chronic illness is among the predictors of OHISB.ConclusionThese findings add to evidence from other countries that had identified health literacy and presence of chronic illness as significant predictors of OHISB among students.
Molecular correlates of invasion pattern in HPV‐associated endocervical adenocarcinoma: emergence of two distinct risk‐stratified tiers
Authors: Sharma Aarti E , Hodgson Anjelica J , Howitt Brooke E , Olkhov‐Mitsel Ekaterina , Djordevic Bojana , Park Kay J , Nucci Marisa R , Parra‐Herran Carlos 
Published: February 2023

BackgroundThe pattern‐based (Silva) classification of invasive human papilloma virus (HPV)‐associated endocervical adenocarcinomas (HPVA) is an established and reproducible method to predict outcomes for this otherwise stage‐dependent group of tumours. Previous studies utilising targeted sequencing have shown a correlation between mutational profiles and an invasive pattern. However, such correlation has not been explored using comprehensive molecular testing.DesignClinicopathologic data including invasive pattern (Silva groups A, B, and C) was collected for a cohort of invasive HPVA, which previously underwent massive parallel sequencing using a panel covering 447 genes. Pathogenic alterations, molecular signatures, tumour mutational burden (TMB), and copy number alterations (CNA) were correlated with pattern of invasion.ResultsForty five HPVA (11 pattern A, 17 pattern B, and 17 pattern C tumours) were included. Patients with pattern A presented at stage I with no involved lymph nodes or evidence of recurrence (in those with >2 months of follow‐up). Patterns B and C patients also mostly presented at stage I with negative lymph nodes, but had a greater frequency of recurrence; 3/17 pattern B and 1/17 pattern C HPVAs harboured lymphovascular space invasion (LVI). An APOBEC mutational signature was detected only in Silva pattern C tumours (5/17), and pathogenic PIK3CA changes were detected only in destructively invasive HPVA (patterns B and C). When cases were grouped as low‐risk (pattern A and pattern B without LVI) and high‐risk (pattern B with LVI and pattern C), high‐risk tumours were enriched in mutations in PIK3CA, ATRX, and ERBB2. There was a statistically significant difference in TMB between low‐risk and high‐risk pattern tumours (P = 0.006), as well as between Pattern C tumours with and without an APOBEC signature (P = 0.002). CNA burden increased from pattern A to C.ConclusionOur findings further indicate that key molecular events in HPVA correlate with the morphologic invasive properties of the tumour and their aggressiveness. Pattern B tumours with LVI clustered with pattern C tumours, whereas pattern B tumours without LVI approached pattern A genotypically. Our study provides a biologic foundation for consolidating the Silva system into low‐risk (pattern A + B without LVI) and high‐risk (pattern B with LVI and pattern C) categories.
How blockchain adoption affects supply chain sustainability in the fashion industry: a systematic review and case studies
Authors: Chen Yue 
Published: February 2023

AbstractThe fashion industry is the fourth biggest industry globally, with a value of $3 trillion and a workforce of 3384 million. However, the rapid development of the fashion industry negatively impacts the environment. With industrial practice, blockchain technology is found to be efficient and effective in helping fashion supply chain members cope with sustainability issues with accessibility, security, traceability, and transparency. This paper makes a systematic literature review and in‐depth exploration of adopting blockchain technology to facilitate sustainable supply chain practices with a particular case study on the fashion industry in coastal areas and a discussion of the application of blockchain technology in the global fashion industry. Based on the combination of the literature review, the case study, and the discussion, managerial insights are generated concerning blockchain adoption for boosting sustainability in the fashion industry in various domains. Future research opportunities are also discussed.
Incidence and risk factors for surgical site infection after medial opening‐wedge high tibial osteotomy using a locking T‐shape plate
Authors: Jia Guoxing , Sun Congcong , Xie Jin , Li Jia , Liu Sen , Dong Wei , Yu Xiaoguang 
Published: February 2023

AbstractMedial opening‐wedge high tibial osteotomy (MOWHTO) is a well‐established surgical method for treatment of isolated medial compartment osteoarthritis with varus deformity, but the surgical outcomes may be compromised by surgical site infection (SSI). This study aimed to investigate the incidence and the risk factors for SSI after MOWHTO. This retrospective study included consecutive patients who underwent MOWHTO for isolated medial compartment osteoarthritis with varus deformity in two tertiary referral hospitals from January 2019 and June 2021. Patients who developed SSI within 12 months of surgery were identified by inquiring the medical records for index hospitalisation, notes of after‐discharge outpatient visits, or records of readmission for treatment of SSI. Univariate comparisons were performed to detect the differences between SSI and non‐SSI groups, and multivariate logistic regression analysis was used to identify the independent risk factors. Six hundred sixteen patients with 708 procedures were included and 30 (4.2%) cases of SSI occurred, with 0.6% rate for deep SSI and 3.6% for superficial. Univariate analyses showed significant difference between groups in terms of morbidity obesity (≥32 kg/m2) (20.0% vs 8.9%), comorbid diabetes (26.7% vs 11.1%), active smoking (20.0% vs 6.3%), time from admission to operation (5.2 ± 4.0 vs 4.1 ± 3.0), size of osteotomy ≥12 mm (40.0% vs 20.0%), type of bone grafting and lymphocyte count (2.1 ± 0.5 vs 1.9 ± 0.6). However, in the multivariate analysis, only active smoking (OR, 3.4; 95% CI, 1.4‐10.2), size of osteotomy ≥12 mm (OR, 2.8; 95% CI, 1.3‐5.9) and allogeneic/artificial vs no bone grafting (OR, 2.4; 95% CI, 1.0‐10.8) remained significant. SSI was not uncommon after MOWHTO, but the majority was superficial. The identified three independent factors, including smoking, size of osteotomy ≥12 mm and allogeneic/artificial bone grafting would help risk assessment and stratification, target risk factor modification and clinical surveillance, and inform patient counselling.
Macroeconomic News in Asset Pricing and Reality
Authors: DUFFEE GREGORY R. 
Published: February 2023

ABSTRACTRevisions in successive Greenbook forecasts of quarterly real GDP growth proxy for news of current and expected future economic growth. In the sample 1975 through 2015, news of future growth is slightly negatively related to contemporaneous changes in Treasury bond yields, while news of current growth is strongly positively related to changes in these yields. Both results are difficult to reconcile with a representative agent's bondholding first‐order condition. A continuous‐time dynamic model of output attributes almost all of the covariation with yields to martingale innovations in log output and a minimal amount to innovations in the conditional drift of log output.
The incidence of Jarisch–Herxheimer reactions and associated risk factors in pregnant women and nonpregnant women: A retrospective chart review at a university hospital in Japan
Authors: Mori Hiroshi , Shibata Eiji , Kondo Emi , Sasaki Natsuko , Sawada Yu , Yoshino Kiyoshi 
Published: February 2023

AbstractAimsJarisch–Herxheimer reactions (JHR) is a transient adverse event that occurs during initial antimicrobial treatment for syphilis patients, and is known to develop uterine contractions and fetal distress in pregnant women complicated with syphilis. The aim of this study is to identify risk factors for JHR in patients with syphilis, and to clarify whether pregnancy status is a risk factor for JHR, and to describe the characteristics of pregnant women who develop JHR.MethodsThis was a retrospective chart review in a singleton university hospital in Japan. We collected data of syphilis patients who were diagnosed and treated at department of obstetrics and gynecology, dermatology between January 2010 and May 2022. There were no validated diagnostic criteria for JHR, we defined JHR as one or more of the following in addition to raised body temperature (≧38.0°C) within 24 h of initial antibiotic treatment: headache, chills, myalgias, tachycardia (≧110 bpm), new rash.ResultsThere were 30 syphilis patients. Of whom nine (30%) were pregnant women and all their neonates were not diagnosed with congenital syphilis. Five patients (17%) developed JHR at the time of initial treatment (JHR group, n = 5). There was no difference between JHR group and non‐JHR group (n = 25) in pregnancy status. Secondary syphilis was an only significant risk factor for JHR. Two pregnant women with JHR were both treated for secondary syphilis in the third trimester of pregnancy.ConclusionPregnancy status was not a risk factor for JHR in syphilis patients. Further research is needed.
Investigating the Student in Returning to Learn After Concussion: A Systematic Review andMeta‐Analysis
Authors: Pei Yalian , Kemp Amy M. , O'Brien Katy H. 
Published: February 2023

AbstractPurposeExamine concussion effects on academic outcomes, including student perspectives.MethodsThis study included a systematic review and meta‐analysis examining post‐concussion school attendance, academic performance, perceptions of academic difficulty, and accommodations for students in elementary through college settings. The analysis considered pre‐ and post‐injury factors, along with injury factors that contribute to post‐concussion academic outcomes.ResultsThe systematic review showed that students with concussion miss more school days and perceive higher levels of academic difficulty, but results about academic performance varied. Meta‐analysis yielded small concussion effects on school absence and academic performance and moderate effects on perceptions of academic difficulty. Female sex, older age, history of migraine, prior concussions, severe or persistent symptoms, vestibular‐ocular motor, and cognitive disruptions are risk factors, but these moderators were not identified in the meta‐analysis due to lack of effect sizes.Implications for School Health Policy, Practice, and EquityThis study confirmed negative concussion effects on academic absences, performance, and perceptions of academic difficulty. Identified contributing factors will guide future practices to support students returning to learn after concussion.ConclusionsNegative impacts to academics from concussion may be amplified by complicating factors. Future investigations are needed to confirm risk factors and mitigating effects of early identification and post‐injury supports.
Influence of abiotic factors on kinetics of viable populations of biocontrol agents in the phyllosphere of lettuce and strawberry leaves
Authors: Tut Gurkan , Magan Naresh , Xu Xiangming 
Published: February 2023

AbstractThere is little information on the effect of temperature, relative humidity (RH) and vapour pressure deficit (VPD) on the viable populations of two commercial biocontrol strains, Bacillus subtilis QST 713 (recently classified as B. velezensis) and Gliocladium catenulatum J1446 (syn. Clonostachys rosea). The PMAxx‐qPCR molecular assay was used to quantify the viable biocontrol agent (BCA) populations on fully extended lettuce and strawberry leaves under a range of temperature and RH combinations. Overall, there was a small decline in the population size of viable cells for the two biocontrol organisms on strawberry and lettuce leaves within 10 days of application. However, for most experimental runs, which contained general UK agronomy climates, such a decline was not statistically significant. Moreover, for a few runs, the viable populations increased significantly in optimal BCA growth temperatures with high RH. Only temperature (ambient) and dew point significantly affected the rate of temporal changes in the viable biocontrol population size. Thus, an increasing temperature led to decreased daily mortality. It should be noted that much of the variability in the estimated daily mortality rates remains unaccounted for, thus unless under extreme conditions, the biocontrol efficacy in practice is less likely to be affected by the survival of biocontrol microbes but more likely by other factors that influence the density of biocontrol cells in the phyllosphere, especially dilution due to rapid host leaf expansion, spray coverage and rain wash‐off.
Amikacin disaggregates platelet clumps inEDTAblood samples from cats and dogs when added postcollection
Authors: Vasilatis Demitria M. , Walker Naomi J. , Borjesson Dori L. 
Published: February 2023

AbstractBackgroundPseudothrombocytopenia may lead to the erroneous diagnosis of thrombocytopenia, resulting in unnecessary testing and treatment. The addition of exogenous substances to blood samples prior to collection has been shown to mitigate platelet (PLT) clumps in blood samples. Postcollection additives aiming to disaggregate PLT clumps have been largely unexplored.ObjectivesWe aimed to determine if the addition of amikacin to blood samples postcollection aids in the disaggregation of PLT clumps in cats and dogs.MethodsFor this prospective study, EDTA‐collected blood samples from 28 cats and 17 dogs were obtained from a hospital population at UC Davis Veterinary Medical Teaching Hospital. Samples had PLT clumps detected on blood smears and thrombocytopenia per analyzer count. Amikacin was added to samples postcollection, and an additional CBC was performed. Flow cytometry was performed to assess PLT‐fibrinogen binding in amikacin‐treated aliquots.ResultsPLT‐clumped samples treated with amikacin significantly increased PLT numbers by 134% and decreased mean platelet volume (MPV) values by 14% (P ≤ 0.0001) in cats, and increased PLT numbers by 32% (P = 0.04) and increased MPV values by 9% (P = 0.02) in dogs. Mean cell volume (MCV) slightly increased (<4%) for both species. No other CBC parameters were substantially affected by the addition of amikacin. Flow cytometry showed decreased PLT‐fibrinogen binding in the majority of cats but was not significant (P > 0.05).ConclusionsAdding amikacin to PLT‐clumped blood samples postcollection may be a convenient solution for pseudothrombocytopenia in cats and dogs. Future studies are needed to elucidate the mechanism of amikacin and its effectiveness under different storage conditions. This is the first reported use of amikacin postcollection to disaggregate PLT clumps in blood samples from animals.
DETERMINATION OF PROCESS VARIABILITY BY USING TRIANGULAR FUZZY NUMBER TO MINIMIZE PRODUCTION LEAD TIME IN A DYNAMIC VALUE STREAM MAPPING
Authors: Thulasi M. , Faieza A.A , Azfanizam A.S , Leman Z. 
Published: February 2023

This paper shows the incorporation of Value Stream Mapping (VSM) with triangular fuzzy numbers to determine variability and uncertainty in a conveyor manufacturing company. VSM is a pen and paper tool which is used to indicate wastes and bottleneck processes graphically and develop an action plan to enhance the production line. However, some weaknesses are identified in the conventional VSM where it fails to consider variability in a dynamic manufacturing environment. As such, this paper fills up the research gap by using Triangular Fuzzy Number (TFN) to illustrate time intervals, inventories and other variables of VSM operation. The purpose of this paper is to minimize total production lead time (TPLT) and total value-added time (TVAT) in the current value stream of the conveyor chain. More accurate details of variability in the dynamic manufacturing environment can be illustrated by a Triangular Fuzzy Number (TFN) of VSM. As a result, the future value stream map shows 50% and 22% reduction in TPLT and TVAT respectively compared to the current value stream. In conclusion, this paper also recommends that in order to optimize the accuracy of VSM analysis further, a discrete event simulation can be used to examine the fuzzy VSM.
Self‐adjoint Laplacians and symmetric diffusions on hyperbolic attractors
Authors: Alikhanloo Shayan , Hinz Michael 
Published: February 2023

AbstractWe construct self‐adjoint Laplacians and symmetric Markov semigroups on hyperbolic attractors, endowed with Gibbs ‐measures. If the measure has full support, we can also conclude the existence of an associated symmetric diffusion process. In the special case of partially hyperbolic diffeomorphisms induced by geodesic flows on negatively curved manifolds the Laplacians we consider are self‐adjoint extensions of well‐known classical leafwise Laplacians. We observe a quasi‐invariance property of energy densities in the ‐conformal case and the existence of nonconstant functions of zero energy.
Obesity and gestational diabetes independently and collectively induce specific effects on placental structure, inflammation and endocrine function in a cohort of South African women
Authors: Musa Ezekiel , Salazar‐Petres Esteban , Arowolo Afolake , Levitt Naomi , Matjila Mushi , Sferruzzi‐Perri Amanda N. 
Published: February 2023

AbstractMaternal obesity and gestational diabetes mellitus (GDM) are associated with insulin resistance and health risks for mother and offspring. Obesity is also characterized by low‐grade inflammation, which in turn, impacts insulin sensitivity. The placenta secretes inflammatory cytokines and hormones that influence maternal glucose and insulin handling. However, little is known about the effect of maternal obesity, GDM and their interaction, on placental morphology, hormones and inflammatory cytokines. In a South African cohort of non‐obese and obese pregnant women with and without GDM, this study examined placental morphology using stereology, placental hormone and cytokine expression using real‐time PCR, western blotting and immunohistochemistry, and circulating TNFα and IL‐6 concentrations using ELISA. Placental expression of endocrine and growth factor genes was not altered by obesity or GDM. However, LEPTIN gene expression was diminished, syncytiotrophoblast TNFα immunostaining elevated and stromal and fetal vessel IL‐6 staining reduced in the placenta of obese women in a manner that was partly influenced by GDM status. Placental TNFα protein abundance and maternal circulating TNFα concentrations were reduced in GDM. Both maternal obesity and, to a lesser extent, GDM were accompanied by specific changes in placental morphometry. Maternal blood pressure and weight gain and infant ponderal index were also modified by obesity and/or GDM. Thus, obesity and GDM have specific impacts on placental morphology and endocrine and inflammatory states that may relate to pregnancy outcomes. These findings may contribute to developing placenta‐targeted treatments that improve mother and offspring outcomes, which is particularly relevant given increasing rates of obesity and GDM worldwide.
imageKey points
Rates of maternal obesity and gestational diabetes (GDM) are increasing worldwide, including in low‐middle income countries (LMIC).
Despite this, much of the work in the field is conducted in higher‐income countries.
In a well‐characterised cohort of South African women, this study shows that obesity and GDM have specific impacts on placental structure, hormone production and inflammatory profile.
Moreover, such placental changes were associated with pregnancy and neonatal outcomes in women who were obese and/or with GDM.
The identification of specific changes in the placenta may help in the design of diagnostic and therapeutic approaches to improve pregnancy and neonatal outcomes with particular significant benefit in LMICs.
Supplemental Material: Geology of a Large Intact Extensional Oceanic Arc Crustal Section with Superior Exposures: Cretaceous Alisitos Arc, Baja California (Mexico)
Authors: Busby C. , al. et 
Published: February 2023

<p>SI-1: Whole-rock X-ray fluorescence (XRF) and inductively coupled plasma–mass spectrometry (ICP-MS) major- and trace-element geochemical data; SI-2: U-Pb zircon data; SI-3: Zircon Hf isotope data; SI-4: Description of all localities plotted on the geologic map (Fig. 4); SI-5: Analytical methods; SI-6: Modal summary for plutonic rocks; and Figure 4A: Geologic map of the Rosario segment of the Alisitos oceanic arc, Baja Calinfornia, Mexico. </p>