bluuebunny/crossref_metadata_2025_split huggingface dataset:
A comparison of machine learning algorithms and traditional regression-based statistical modeling for predicting hypertension incidence in a Canadian population
Authors: Chowdhury Mohammad Ziaul Islam , Leung Alexander A. , Walker Robin L. , Sikdar Khokan C. , O’Beirne Maeve , Quan Hude , Turin Tanvir C. 
Published: January 2023

AbstractRisk prediction models are frequently used to identify individuals at risk of developing hypertension. This study evaluates different machine learning algorithms and compares their predictive performance with the conventional Cox proportional hazards (PH) model to predict hypertension incidence using survival data. This study analyzed 18,322 participants on 24 candidate features from the large Alberta’s Tomorrow Project (ATP) to develop different prediction models. To select the top features, we applied five feature selection methods, including two filter-based: a univariate Cox p-value and C-index; two embedded-based: random survival forest and least absolute shrinkage and selection operator (Lasso); and one constraint-based: the statistically equivalent signature (SES). Five machine learning algorithms were developed to predict hypertension incidence: penalized regression Ridge, Lasso, Elastic Net (EN), random survival forest (RSF), and gradient boosting (GB), along with the conventional Cox PH model. The predictive performance of the models was assessed using C-index. The performance of machine learning algorithms was observed, similar to the conventional Cox PH model. Average C-indexes were 0.78, 0.78, 0.78, 0.76, 0.76, and 0.77 for Ridge, Lasso, EN, RSF, GB and Cox PH, respectively. Important features associated with each model were also presented. Our study findings demonstrate little predictive performance difference between machine learning algorithms and the conventional Cox PH regression model in predicting hypertension incidence. In a moderate dataset with a reasonable number of features, conventional regression-based models perform similar to machine learning algorithms with good predictive accuracy.
Combining convolutional neural networks and self-attention for fundus diseases identification
Authors: Wang Keya , Xu Chuanyun , Li Gang , Zhang Yang , Zheng Yu , Sun Chengjie 
Published: January 2023

AbstractEarly detection of lesions is of great significance for treating fundus diseases. Fundus photography is an effective and convenient screening technique by which common fundus diseases can be detected. In this study, we use color fundus images to distinguish among multiple fundus diseases. Existing research on fundus disease classification has achieved some success through deep learning techniques, but there is still much room for improvement in model evaluation metrics using only deep convolutional neural network (CNN) architectures with limited global modeling ability; the simultaneous diagnosis of multiple fundus diseases still faces great challenges. Therefore, given that the self-attention (SA) model with a global receptive field may have robust global-level feature modeling ability, we propose a multistage fundus image classification model MBSaNet which combines CNN and SA mechanism. The convolution block extracts the local information of the fundus image, and the SA module further captures the complex relationships between different spatial positions, thereby directly detecting one or more fundus diseases in retinal fundus image. In the initial stage of feature extraction, we propose a multiscale feature fusion stem, which uses convolutional kernels of different scales to extract low-level features of the input image and fuse them to improve recognition accuracy. The training and testing were performed based on the ODIR-5k dataset. The experimental results show that MBSaNet achieves state-of-the-art performance with fewer parameters. The wide range of diseases and different fundus image collection conditions confirmed the applicability of MBSaNet.
High performance antenna-on-chip inspired by SIW and metasurface technologies for THz band operation
Authors: Alibakhshikenari Mohammad , Virdee Bal S. , Rajaguru Renu Karthick , Iqbal Amjad , Al‑Hasan Muath , See Chan H. , Falcone Francisco 
Published: January 2023

AbstractIn this paper, a high-performance antenna-on-chip (AoC) is implemented on gallium arsenide (GaAs) wafer based on the substrate integrated waveguide (SIW) and metasurface (MTS) technologies for terahertz band applications. The proposed antenna is constructed using five stacked layers comprising metal-GaAs-metal-GaAs-metal. The conductive electromagnetic radiators are implemented on the upper side of the top GaAs layer, which has a metallic ground-plane at its underside. The metallic feedline is implemented at the underside of the bottom GaAs layer. Dual wrench-shaped radiators are framed by metallic vias connected to the ground-plane to create SIW cavity. This technique mitigates the surface waves and the substrate losses, thereby improving the antenna’s radiation characteristics. The antenna is excited by a T-shaped feedline implemented on the underside of the bottom GaAs substrate layer. Electromagnetic (EM) energy from the feedline is coupled to the radiating elements through the circular and linear slots etched in the middle ground-plane layer. To mitigate the surface-wave interactions and the substrate losses in the bottom GaAs layer, the feedline is contained inside a SIW cavity. To enhance the antenna’s performance, the radiators are transformed into a metamaterial-inspired surface (i.e., metasurface), by engraving periodic arrangement of circular slots of sub-wavelength diameter and periodicity. Essentially, the slots act as resonant scatterers,which control the EM response of the surface. The antenna of dimensions of 400 × 400 × 8 μm3is demonstrated to operate over a wide frequency range from 0.445 to 0.470 THz having a bandwidth of 25 GHz with an average return-loss of − 27 dB. The measured average gain and radiation efficiency are 4.6 dBi and 74%, respectively. These results make the proposed antenna suitable for AoC terahertz applications.
Expanded genetic testing of GIST patients identifies high proportion of non-syndromic patients with germline alterations
Authors: Mandelker Diana , Marra Antonio , Mehta Nikita , Selenica Pier , Yelskaya Zarina , Yang Ciyu , Somar Joshua , Mehine Miika , Misyura Maksym , Basturk Olca , Latham Alicia , Carlo Maria , Walsh Michael , Stadler Zsofia K. , Offit Kenneth , Bandlamudi Chaitanya , Hameed Meera , Chi Ping , Reis-Filho Jorge S. , Ceyhan-Birsoy Ozge 
Published: January 2023

AbstractTraditional genetic testing for patients with gastrointestinal stromal tumors (GISTs) focus on those with syndromic features. To assess whether expanded genetic testing of GIST patients could identify hereditary cancer predisposition, we analyzed matched tumor-germline sequencing results from 103 patients with GISTs over a 6-year period. Germline pathogenic/likely pathogenic (P/LP) variants in GIST-associated genes (SDHA, SDHB, SDHC, NF1, KIT) were identified in 69% of patients with KIT/PDGFRA-wildtype GISTs, 63% of whom did not have any personal or family history of syndromic features. To evaluate the frequency of somatic versus germline variants identified in tumor-only sequencing of GISTs, we analyzed 499 de-identified tumor-normal pairs. P/LP variants in certain genes (e.g., BRCA1/2, SDHB) identified in tumor-only sequencing of GISTs were almost exclusively germline in origin. Our results provide guidance for genetic testing of GIST patients and indicate that germline testing should be offered to all patients with KIT/PDGFRA-wildtype GISTs regardless of their history of syndromic features.
Friction hysteretic behavior of supported atomically thin nanofilms
Authors: Xu Chaochen , Ye Zhijiang , Egberts Philip 
Published: January 2023

AbstractHysteretic friction behavior has been observed on varied 2D nanofilms. However, no unanimous conclusion has yet been drawn on to the exact mechanism or relative contribution of each mechanism to the observed behavior. Here we report on hysteretic friction behavior of supported atomically thin nanofilms studied using atomic force microscopy (AFM) experiments and molecular dynamics (MD) simulations. Load dependent friction measurements were conducted on unheated and heated samples of graphene, h-BN, and MoS2 supported by silica substrates. Two diverging friction trends are reported: the unheated samples showed higher friction during unloading than during loading, and the heated samples showed a reversed hysteresis. Further, the friction force increased sub-linearly with normal force for heated samples, compared with unheated samples. Tapping mode AFM suggested that the interaction strength of the substrate was increased with heating. Roughened substrates in the MD simulations that mimicked strong/weak interaction forces reproduced the experimental observations and revealed that the evolution of real contact area in different interface interaction situation caused the diverging behaviors. Surface roughness and interaction strength were found to be the key parameters for controlling the out-of-plane deformation of atomically thin nanofilms.
Synthesis of trans-1,2-dimetalloalkenes through reductive anti-dimagnesiation and dialumination of alkynes
Authors: Takahashi Fumiya , Kurogi Takashi , Yorimitsu Hideki 
Published: January 2023

AbstractPolar reactive organometallic species have been key reagents in synthesis for more than a century. Stereodefined 1,2-dimetallated alkenes offer promising synthetic utility; however, few methods are available for their preparation due to their relatively low stability. Here we report the reductive anti-1,2-dimetallation of alkynes to stereoselectively generate trans-1,2-dimagnesio- and 1,2-dialuminoalkenes, which are stable and have been demonstrated in organic synthesis. These stereodefined 1,2-dimetallated alkenes are prepared through the use of a sodium dispersion as a reducing agent, and organomagnesium and organoaluminium halides as reduction-resistant electrophiles. Highly nucleophilic 1,2-dimagnesioalkenes serve as dual Grignard reagents and have been demonstrated to react with various electrophiles to afford anti-difunctionalized alkenes. The 1,2-dialuminoalkenes react with paraformaldehyde with dearomatization of the aryl moieties to form the corresponding dearomatized 1,4-diols, with the overall reaction being regarded as alkynyl-directed dearomatization of arenes. X-ray crystallographic analysis further supports the formation of trans-1,2-dimagnesio- and 1,2-dialuminoalkenes, with computational studies providing insight into the mechanism of dearomative difunctionalization.
Advances in Exploring Cyclopentadienyl (Cp) Rhodium Catalysts Featuring Diastereotopic or Enantiotopic Cp Faces for Asymmetric C–H Activation
Authors: Wang Jun , Yan Xiaoqiang 
Published: January 2023

AbstractChiral cyclopentadienyl rhodium (CpRh) complexes have emerged as a class of powerful catalysts for enantioselective C–H activation reactions. In terms of Cp ligand development, the mainstream is to design chiral ligands with C
2 symmetry in order to avoid the problem of Cp face selectivity during their metalation with rhodium. In recent years, CpRh catalysts with diastereotopic or enantiotopic Cp faces were also revealed and successfully applied in asymmetric C–H activation. These advances are summarized in this short review together with perspectives for their future development.1	Introduction2	Cp Ligands with Diastereotopic Cp Faces3	Cp Ligands with Enantiotopic Cp Faces4	Conclusion and Outlook
A Mn(OAc)3-Triggered Formation of Cyclopropanes from Ugi Adducts
Authors: El Kaïm Laurent , Cheibas Cristina , Vieu Emilie , Casaretto Nicolas , Vitale Maxime , Grimaud Laurence 
Published: January 2023

AbstractUgi adducts involving malonic acid monoesters and dialkoxy-substituted aromatic aldehydes can undergo an oxidative dearomatization when treated with Mn(OAc)3 leading to the formation of fused cyclopropanes as observed in the Buchner reaction of diazo compounds.
Addition of Alcohols onto Electron-Deficient Heteroarenium Salts: A Reversible Covalent Bonding Process under Basic Conditions
Authors: Chen Baoli , Li En , Chen Jiean , Huang Yong , Song Feifei , Guimond Nicolas 
Published: January 2023

AbstractThe reversible addition of benzyl alcohol onto heteroarenium salts under basic conditions was studied. Fine-tuning of the nature of the arenium and substituents allowed the discovery of a range of pyrimidinium substrates that can undergo C6-selective alcohol addition. Crossover experiments were also performed to confirm the addition-elimination equilibrium under basic conditions.
Anti-glutamatergic Effects of Three Lignan Compounds: Arctigenin, Matairesinol and Trachelogenin – An ex vivo Study on Rat Brain Slices
Authors: Koech Peter Kiplangʼat , Jócsák Gergely , Boldizsár Imre , Moldován Kinga , Borbély Sándor , Világi Ildikó , Dobolyi Arpád , Varró Petra 
Published: January 2023

AbstractArctigenin is a bioactive dibenzylbutyrolactone-type lignan exhibiting various pharmacological activities. The neuroprotective effects of arctigenin were demonstrated to be mediated via
inhibition of AMPA and KA type glutamate receptors in the somatosensory cortex of the rat brain. The aim of this study was to compare the effects of arctigenin with matairesinol and
trachelogenin on synaptic activity in ex vivo rat brain slices. Arctigenin, matairesinol and trachelogenin were isolated from Arctium lappa, Centaurea scabiosa and Cirsium
arvense, respectively, and applied on brain slices via perfusion medium at the concentration range of 0.5 – 40 µM. The effects of the lignans were examined in the CA1 hippocampus and the
somatosensory cortex by recording electrically evoked field potentials. Arctigenin and trachelogenin caused a significant dose-dependent decrease in the amplitude of hippocampal population
spikes (POPS) and the slope of excitatory postsynaptic potentials (EPSPs), whereas matairesinol (1 µM and 10 µM) decreased EPSP slope but had no effect on POPS amplitude. Trachelogenin
effect (0.5 µM, 10 µM, 20 µM) was comparable to arctigenin (1 µM, 20 µM, 40 µM) (p > 0.05). In the neocortex, arctigenin (10 µM, 20 µM) and trachelogenin (10 µM) significantly decreased
the amplitude of evoked potential early component, while matairesinol (1 µM and 10 µM) had no significant effect (p > 0.05). The results suggest that trachelogenin and arctigenin act via
inhibition of AMPA and KA receptors in the brain and trachelogenin has a higher potency than arctigenin. Thus, trachelogenin and arctigenin could serve as lead compounds in the development
of neuroprotective drugs.
Stem Cells in the Periodontium—Anatomically Related Yet Physiologically Diverse
Authors: Ponnaiyan Deepa , Rughwani Roshan R. , Victor Dhayanand John , Shetty Ganesh 
Published: January 2023

AbstractPeriodontitis is a complex chronic disease discernible by the deterioration of periodontal tissue. The goal of periodontal therapy is to achieve complete tissue regeneration, and one of the most promising treatment options is to harness the regenerative potential of stem cells available within the periodontal complex. Periodontal ligament stem cells, gingival mesenchymal stem cells, oral periosteal stem cells, and dental follicle stem cells have structural similarities, but their immunological responses and features differ. The qualities of diverse periodontal stem cells, their immune-modulatory effects, and variances in their phenotypes and characteristics will be discussed in this review. Although there is evidence on each stem cell population in the periodontium, understanding the differences in markers expressed, the various research conducted so far on their regenerative potential, will help in understanding which stem cell population will be a better candidate for tissue engineering. The possibility of selecting the most amenable stem cell population for optimal periodontal regeneration and the development and current application of superior tissue engineering treatment options such as autologous transplantation, three-dimensional bioengineered scaffolds, dental stem cell-derived extracellular vesicles will be explored.
What Is the Safest Intersurgical Interval between Staged Bilateral Total Knee Arthroplasty? A Nationwide Analysis of 20,279 Patients
Authors: Pan Xuankang , Emara Ahmed K. , Zhou Guangjin , Koroukian Siran , Klika Alison K. , Molloy Robert M. , Piuzzi Nicolas S. 
Published: January 2023

AbstractIn staged bilateral total knee arthroplasty (BTKA), the intersurgical time is yet to be determined. This study aimed to (1) test for differences in in-hospital metrics between the index and contralateral TKA and (2) determine the safest intersurgical time interval to minimize adverse outcomes after the contralateral surgery. The National Readmissions Database was queried for patients who received staged BTKA (2016–2017). A total of 20,279 patients were included. Demographics, comorbidities, baseline determinants, and intersurgical time between index and contralateral TKAs (≤ 3 month, 4–6 months, 7–9 months, and 10–12 months intervals) were captured. Outcomes included healthcare utilization (length of stay [LOS] and nonhome discharge), in-hospital costs, and in-hospital complications. Outcomes were compared between index versus contralateral surgeries and among contralateral surgeries of various intersurgical intervals. Contralateral surgeries had shorter LOS (2.2 ± 1.9 vs. 2.4 ± 2.0 days; p < 0.001), lower nonhome discharge (n = 2692[13.2%] vs. n = 2963[14.7%]; p = 0.001), and in-hospital costs ($16,476 ± $7,404 vs. 16,774 ± $9,621; p < 0.001), but similar rates of nonmechanical (p = 0.40) complications compared with index TKA. Multivariable regression demonstrated that intersurgical time was not associated with nonmechanical complications or transfusion, or 30-day readmission (p > 0.05, each). Compared with the less than or equal to 3-month interval, the 4 to 6-month interval exhibited highest odds ratio (OR) of any infection (OR: 1.81; 95% confidence interval [CI]: [1.13–2.88]; p = 0.013), urinary tract infection (OR:1.81, 95%CI: [1.13–2.90]; p = 0.014), and any-cardiac complications (OR:1.17; 95%CI: [1.01–1.35]; p = 0.037). Patients in the 10–12-month cohort had lowest odds of posthemorrhagic anemia (OR: 0.84; 95% CI: [0.72–0.98]; p = 0.03). Overall, the second surgery of a staged BTKA has lower healthcare utilization despite similar complication rates. While patients in the 10 to 12-month intersurgical interval had the most favorable overall safety profile, no single interval exhibited consistently lower complications for all measured outcomes. Special care pathways should be optimized to care for patients undergoing staged BTKA.
Does Time Spent in the Post-Anesthesia Care Unit Affect Hospital Lengths of Stay following Primary Total Knee Arthroplasty?
Authors: Sayegh Michael J. , Garbarino Luke J. , Gold Peter A. , Anis Hiba K. , Chen Zhongming , Sodhi Nipun , Danoff Jonathan R. , Mont Michael A. 
Published: January 2023

AbstractGiven the current healthcare economic environment, substantial efforts have been made to help streamline the in-hospital care for total knee arthroplasty (TKA) patients. While potential cost-reducing factors have been identified in the literature, analyses specifically considering post-anesthesia care unit (PACU) lengths of stay (LOS) are lacking. Therefore, the purpose of this study was to identify factors associated with (1) longer PACU LOS as well as (2) longer Hospital LOS. Prospectively collected TKA data from seven participating hospitals within a large health system were evaluated for patient demographics, body mass indices, Charlson Comorbidity Indices (CCI), surgeon volumes/training, admission types, anesthesia types, PACU LOS, and overall hospital LOS. Complete data was available for 1,690 patients (1,082 females, mean age: 67 years). Univariate and multivariate analytical models were constructed to identify which factors were predictive of longer PACU and overall hospital LOS. Same-day admissions, higher volume surgeons (≥ 100 cases per year), fellowship-trained arthroplasty surgeons, and longer operative times were associated with longer PACU LOS (p < 0.05). Multivariate analyses found age more than or equal to 65 years (β= 0.124) and CCI more than or equal to 3 (β= 0.088) to be associated with longer hospital LOS (p < 0.001). Operative times, PACU LOS, and procedure times (operative time plus PACU LOS) were not associated with longer hospital LOS (p > 0.05). These data identify associative factors for PACU LOS, as well as the influence of time spent in the PACU on overall hospital LOS. Interestingly, this analysis revealed that patients of arthroplasty fellowship-trained and higher-volume surgeons had longer PACU LOS; however, this could be explained by the observation that these particular surgeons tend to perform more complex deformity cases. Also of importance, increased PACU LOS, meaning the patient spent more time in a high-monitored setting immediately after surgery, did not necessarily confer a longer overall hospital LOS. Based on these data, it may be more beneficial to identify alternate sources than time spent in the operating room or PACU to potentially help reduce overall hospital LOS.
Level of Evidence II, prospective cohort
Fermionic-propagator and alternating-basis quantum Monte Carlo methods for correlated electrons on a lattice
Authors: Janković Veljko , Vučičević Jakša 
Published: January 2023

Ultracold-atom simulations of the Hubbard model provide insights into the character of charge and spin correlations in and out of equilibrium. The corresponding numerical simulations, on the other hand, remain a significant challenge. We build on recent progress in the quantum Monte Carlo (QMC) simulation of electrons in continuous space and apply similar ideas to the square-lattice Hubbard model. We devise and benchmark two discrete-time QMC methods, namely the fermionic-propagator QMC (FPQMC) and the alternating-basis QMC (ABQMC). In FPQMC, the time evolution is represented by snapshots in real space, whereas the snapshots in ABQMC alternate between real and reciprocal space. The methods may be applied to study equilibrium properties within the grand-canonical or canonical ensemble, external field quenches, and even the evolution of pure states. Various real-space/reciprocal-space correlation functions are also within their reach. Both methods deal with matrices of size equal to the number of particles (thus independent of the number of orbitals or time slices), which allows for cheap updates. We benchmark the methods in relevant setups. In equilibrium, the FPQMC method is found to have an excellent average sign and, in some cases, yields correct results even with poor imaginary-time discretization. ABQMC has a significantly worse average sign, but also produces good results. Out of equilibrium, FPQMC suffers from a strong dynamical sign problem. On the contrary, in ABQMC, the sign problem is not time-dependent. Using ABQMC, we compute survival probabilities for several experimentally relevant pure states.