bluuebunny/crossref_metadata_2025_split huggingface dataset:
URGENSI PENDIDIKAN ANTI KORUPSI DI SEKOLAH
Authors: Shaliadi Ikrom , Dannur Moh. 
Published: September 2023

Tujuan penelitian ini untuk menganalisis urgensi pendidikan anti korupsi di Sekolah. Metode yang digunakan adalah metode penelitian kualitatif dengan jenis penelitian studi pustaka. Jenis penelitian studi pustaka digunakan untuk menggali pemahaman yang mendalam tentang suatu topik atau fenomena dengan menganalisis literatur dan sumber-sumber yang relevan yang dimana dalam penelitian ini berkaitan dengan urgensi pendidikan anti korupsi di Sekolah. Adapun data, diperoleh melalui kajian dan analisis terhadap berbagai referensi seperti buku, jurnal ilmiah, artikel, dan dokumen-dokumen lainnya yang berkaitan dengan topik yang diteliti dan kemudian peneliti menarik benang merah dan menyimpulkan dari hasil temuan dan kajian penelitian. Hasil penelitian ini mendapatkan kesimpulan pendidikan anti korupsi di sekolah menjadi sangat krusial di Indonesia saat ini. Melalui pendidikan ini, siswa akan menerima pemahaman yang mendalam tentang korupsi, dampaknya, dan bagaimana cara mencegahnya. Pendidikan anti korupsi akan membentuk sikap, perilaku, dan nilai-nilai siswa yang integritas, adil, dan transparan. Dengan melibatkan semua pemangku kepentingan dan melaksanakan pendekatan holistik, pendidikan anti korupsi di sekolah dapat membantu mengatasi darurat korupsi dan membawa perubahan positif dalam pembangunan Indonesia
Ex auditorio - 13.09.1991
Authors: Nordenbo Sven Erik 
Published: September 2023

i anledning afBo Jacobsen: Studier i dansk voksenundervisning og folkeoplysning. Socio-psykologiske analyser.København: Akademisk Forlag, 1991, 366 sider.
Artiklen gengiver den ordrette opposition ved Bo Jacobsens disputatsforsvar. Oppositionen rummer tre hovedkritikker, samt tre diagnosticerende bemærkninger.Det konstateres for det første, at disputatsen bygger på en »pædagogisk grundmodel«, der reelt er en model for pædagogisk evaluering. Det søges vist, at denne mode~ grundet præses' bestemmelse af behovs-begrebet, ikke vil kunne fungere som ønsket. Det hævdes for det andet, at præses på utilladelig milde i disputatsen sammenblander teoretiske elementer fra forskelligartede teorier. Og for det tredie, at præses anvender Poppers videnskabsteoretiske anvisninger på en fejlagtig måde.De tre diagnosticerende bemærkninger fremdrager, hvad vi i al almindelighed kan lære af det foreliggende arbejde, nemlig: ( 1) atden pædagogiske teoridannelse er nødt til at distancere sig fra de paradigmer, man almindeligvis diskuterer pædagogik inden for ioffentligheden, (2) at forsøg på fastholde en meget omfattende del af den pædagogiske virkelighed videnskabeligt på den pædagogiske videnskabs nuværende udviklingstrin er ufrugtbart, fordi en sådan tilgang snarere rummer et pædagogisk program frem for en pædagogisk analyse, og (3) at en frugtbar forskning i voksenpædagogiske forhold indtil videre først og fremmest bør ske på et fagdidaktisk grundlag.
Protective effect of astaxanthin nanoemulsion on mammalian inner ear hair cells
Authors: Kobayashi Yuki , Sugahara Kazuma , Takemoto Yosuke , Tsuda Junko , Hirose Yoshinobu , Hashimoto Makoto , Yamashita Hiroshi 
Published: September 2023

Background
Aminoglycoside antibiotics are used for treating certain acute infections. However, these drugs cause ototoxicity by inducing inner ear hair cell death.

Aims/Objectives
We investigated the protective effect of a nanoemulsion of the carotenoid astaxanthin on mammalian inner ear hair cells against neomycin-induced ototoxicity.

Material and Methods
Dose-response relationship, quantification of hair cell loss, and reactive oxygen species production were assayed in response to neomycin with and without astaxanthin in cultured utricles of CBA/N mice. In addition, auditory brain response (ABR) and hair cell loss after exposure to the nanoformulation and loud noise were examined in vivo in guinea pigs.

Results
Astaxanthin suppressed neomycin-induced reduction of hair cells by reducing the production of hydroxy radicals. Furthermore, hair cell loss in the second rotation of the cochlea was significantly lower in the astaxanthin group than in the noise-only group.

Conclusions and Significance
The blood-labyrinth barrier limits the successful delivery of drugs for inner ear complications. However, in the nanoemulsion form, astaxanthin can penetrate the round window (fenestra ovale) membrane, enabling topical administration. Thus, astaxanthin nanoemulsion could be useful in treating ototoxicity in individuals with inner ear complications.
Ferrostatin-1 post-treatment attenuates acute kidney injury in mice by inhibiting ferritin production and regulating iron uptake-related proteins
Authors: Zhao Yanxiu , Jiang Binhua , Huang Dinghui , Lou Juxiang , Li Guoshun , Liu Jianqi , Duan Fuhui , Yuan Yuan , Su Xiaoyan 
Published: September 2023

Background
Acute kidney injury (AKI) is a common and serious medical condition with high morbidity and mortality. Recent research has highlighted ferroptosis, a novel form of programmed cell death, as a potential therapeutic target in mitigating renal tubular injury in AKI. Ferrostatin-1, a specific ferroptosis inhibitor, has been demonstrated to prevent renal injury through ferroptosis inhibition.

Methods
Utilizing a murine AKI model, we investigated the effects of Ferrostatin-1 by administering it post-injury. Through high-throughput sequencing and pathological analysis, we focused on the critical role of ferroptosis-related pathways in the treatment.

Results
Ferrostatin-1 post-conditioning effectively mitigated oxidative damage and reduced iron content associated with AKI. Additionally, critical ferroptosis-related proteins, such as GPX4, SLC7A11, NRF2, and FTH1, exhibited increased expression levels. In vitro, Ferrostatin-1 treatment of HK-2 cells significantly diminished lipid peroxidation and iron accumulation. Furthermore, Ferrostatin-1 was found to downregulate the PI3K signalling pathway.

Conclusion
Ferrostatin-1 acted as a potential ferroptosis inhibitor with the capacity to enhance antioxidant defences. This study suggests that Ferrostatin-1 could serve as a promising novel strategy for improving the treatment of AKI and promoting recovery from the condition.
Effect of Levels of Phosphorus and Zinc-EDTA on Growth and Yield of Blackgram (Vigna mungo L.) in Zinc-Deficient Vertisol
Authors: Chama Tasso , Shanmugasundaram R. , Selvi D. , Chandrasekhar C. N. , Srinivasan K. 
Published: September 2023

Aim: In pursuit of optimizing crop productivity and nutritional quality, this study aimed to investigate the influence and interaction of phosphorus (P) and zinc (Zn) on the growth, yield, and quality parameters of Blackgram (Vigna mungo L.), variety VBN 8.
Study Design: The experiment was designed using Factorial Randomized Block Design (FRBD), incorporating 12 treatment combinations and three replications.
Place and duration of Study: The experiment was conducted in the field no. A 4 of Wetland farm, Tamil Nadu Agricultural University, Coimbatore; from May 2023 to August 2023.
Methodology: The experiment consisted of 12 treatments, each replicated three times, resulting in a total of 36 experimental plots. The treatments included different combinations of P levels (0, 25, 50, and 75 kg ha-1) and concentrations of foliar-applied Zn-EDTA (0%, 0.5%, and 1.0%) applied twice at 30 and 45 days after sowing. The recommended dose of nitrogen (N) and potassium (K2O) at 25 kg ha-1 each, along with a recommended dose of zinc sulfate (ZnSO4) at 25 kg ha-1, was applied as a blanket recommendation to ensure consistent nutrient supply across treatments.
Results: It was found that the treatment combination of 50 kg ha-1 P2O5 and 0.5% Zn-EDTA increased morphological characters and yield compared to other treatments followed by treatment combination of 50 kg ha-1 P2O5 and 1% Zn-EDTA. The minimum yield and morphological characters were recorded in the control plot where neither P2O5 nor Zn-EDTA was applied.
Conclusion: This research depicted that the combined application of 50 kg ha-1 P2O5 and 0.5% Zn-EDTA spray has a positive impact on the growth, yield and quality of blackgram in zinc deficient soil under field conditions resulting in improved morphological characters and crop yield. Hence, it may be concluded that an optimum dose of 50 kg ha-1 P2O5 and 0.5% Zn-EDTA spray can be recommended for blackgram to enhance crop productivity.
Primary Endovascular Thrombectomy in Acute Ischemic Stroke in Patients Ineligible for Intravenous Thrombolysis
Authors: Ahmed Raed , Yassin Ossama , Ghaly Azza , Bonafe Alain , Tageldeen Elsayed 
Published: September 2023

Endovascular treatment (EVT) of acute ischemic stroke (AIS) is the main treatment of large vessel occlusion (LVO). Nonetheless, access to EVT is limited specially in developing countries. It is not uncommon in these regions to miss the time window for intravenous thrombolysis (IVT) or to arrive within the IVT window but with a contraindication for it. Hence, a lot of patients with LVO face a situation where either they receive EVT only or conservative management according to available logistics.
Aim: To study the outcome of EVT vs best medical treatment (BMT) in two Egyptian stroke centres (Tanta and Alexandria) in AIS patients ineligible for IVT.
Results: 390 patients with AIS and LVO were included in the study. 74 underwent EVT while 316 underwent BMT. There were no statistical differences in age, sex, time of onset, initial severity, or imaging scores in both groups. The EVT group had more diabetes mellitus (DM) patients, more smokers and more systolic and diastolic blood pressure (BP) while the BMT had more anticoagulated patients. The EVT group had better functional outcome but more symptomatic intracerebral haemorrhage with no difference in mortality.
Conclusion: Endovascular treatment doubles the good functional outcome of AIS in LVO patients but ICH is more with no effect on mortality.
Curved Architected Triboelectric Metamaterials: Auxeticity‐Enabled Enhanced Figure‐of‐Merit
Authors: Chen Haoyu , Shi Jiahao , Akbarzadeh Abdolhamid 
Published: September 2023

AbstractTriboelectric generators are integrated into curved architected materials to realize triboelectric metamaterials that simultaneously harvest electricity from wasted mechanical energy and perform mechanical energy absorption. Novel triboelectric mechanical metamaterials (TMMs) of distance‐changing, angle‐changing, and mixed modes are designed, fabricated, and tested under a cyclic compressive load. The open‐circuit voltage and short‐circuit current of lightweight TMMs are found to be as high as 40 V and 10 nA. The introduced TMMs can effectively harvest energy under loadings from two distinctive directions. A theoretical model for predicting the energy harvesting properties of TMMs is developed, and the role of auxeticity on the energy harvesting figure‐of‐merit (FOMes) is elicited. The introduced TMMs exhibit enhanced FOMes enabled by a decrease in their negative Poisson's ratio and an increase in their resilience. The FOMes of curved architected TMMs surpasses by more than 16 times the FOMes of triboelectric materials with conventional architectures (i.e., triangular, quadrilateral, and hexagonal cell topologies). An intelligent skateboard with integrated TMMs is fabricated as a proof of concept to demonstrate motion sensing, shock‐absorbing, and energy harvesting functionalities of multimodal triboelectric metamaterials. The introduced design strategy for triboelectric metamaterials unlocks their applications in self‐powered and self‐monitoring sports equipment, smart soft robots, and large‐scale energy harvesters.
Metasurface‐Driven and Nanomaterial‐Coupled Plasmonic Biosensor for the Rapid and Quantitative Clinical Identification of Neutralizing Antibodies against SARS‐CoV‐2 Variants
Authors: Li Rui , Zhao Ya , Fan Hongli , Zhou Hanlin , Yin Shaoping , Zhang Qiang , Jin Meilin , Liu Gang L. , Huang Liping 
Published: September 2023

AbstractA robust serological test is required to detect neutralizing antibodies (NAbs) against severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2). A nanomaterial‐coupled metasurface plasmon resonance (MetaSPR) biosensor is developed for rapid multiplexing quantitative tests of the half maximal inhibitory concentration (IC50) value of SARS‐CoV‐2 NAbs in human sera. This biosensor is applied to a MetaSPR competitive or surrogate virus neutralization test (MSPR VNT) used for quantifying NAb‐mediated blockage of the interaction between the human angiotensin‐converting enzyme 2 (hACE2) receptor and the receptor‐binding domain (RBD) of the SARS‐CoV‐2 spike protein. Novel nanomaterial, gold platinum nanoflowers (Au@Pt NFs), is combined with the optimized MetaSPR chip for dual signal amplification. The clinical utility of this biosensor is validated in 40 participants, and the results are confirmed with the IC50 values calculated using the pseudovirus neutralization test. Similarly, the neutralization titer of Omicron and Delta variants and the ability of NAbs to resist these variants are monitored. The MSPR VNT miniaturized optical biosensor instrument has a high throughput and enables one‐step, rapid, and accurate quantification of SARS‐CoV‐2 variants or viruses causing other infectious diseases, which is applicable in vaccine trials, immune response studies, and epidemiological studies.
Boosting Photocatalytic Hydrogen Evolution Through Local Charge Polarization in Chemically Bonded Single‐Molecule Junctions Between Ketone Molecules and Covalent Organic Frameworks
Authors: Huang Kaihui , Bai Junxian , Shen Rongchen , Li Xiuzhi , Qin Chaochao , Zhang Peng , Li Xin 
Published: September 2023

AbstractEfficient charge carrier separation is widely recognized as crucial for effective photocatalytic solar energy conversion. Although certain covalent organic frameworks (COFs) exhibit visible light absorption, rapid carrier recombination often severely restricts their photocatalytic efficiency. This study presents a novel molecular‐engineering approach to enhance carrier separation in 2D substoichiometric COFs post‐treatment with polar ketone molecules. Remarkably, through molecular engineering, incorporating polar ketone molecules induces local charge polarization within the COFs, substantially improving photocatalytic hydrogen evolution performance. Specifically, the modified COFs single‐molecule junctions demonstrate a 5.6‐fold increase in efficiency compared to the unmodified COFs. Experimental and theoretical investigations provide comprehensive evidence that introducing ketone‐based single‐molecule junctions induces local charge polarization and delocalization, thereby facilitating efficient carrier separation, rapid charge transfer, and enhanced dispersion in water. These findings validate the potential of fine‐tuning the carrier separation properties of COFs at the molecular level, offering new prospects for artificial photosynthesis.
Interface Interaction Enhanced Piezo‐Catalytic Hydrogen Peroxide Generation via One‐Electron Water Oxidation
Authors: Wen Yingying , Liu Wei , Wang Peifang , Che Huinan , Tang Chunmei , Liu Bin , Ao Yanhui 
Published: September 2023

AbstractPiezo‐catalysis, which is possible to utilize natural mechanical energy, is an ideal technology for synthesizing hydrogen peroxide (H2O2) but is still challenging. Herein, C‐layer coated ZnO (C‐ZnO) with modulated electronic structure is constructed for piezo‐catalytic H2O2 generation. The C‐layer not only provides more active sites but also induces higher piezo‐response to mechanical stimuli. As a result, the optimized C‐ZnO exhibits ultrahigh piezocatalytic activity for H2O2 yield with a rate of 294 µM h−1 in pure water. Theoretical calculation demonstrates that the interaction at the interface induces charge redistribution, leading to the hole accumulation on the surface, thus promoting one‐electron water oxidation. In addition, the C‐ZnO exhibits excellent piezo‐catalytic performance for the degradation of different pollutants. This study not only provides a promising way (utilization of mechanical energy) for efficient H2O2 production in pure water but also opens a new avenue for designing highly active piezo‐catalytic systems for pollutants degradation.
Greatly Boosting Seawater Hydrogen Evolution by Surface Amorphization and Morphology Engineering on MoO2/Ni3(PO4)2
Authors: Lu Jianxi , Chen Songbo , Zhuo Yuling , Mao Xinya , Liu Dong , Wang Zhenbo 
Published: September 2023

AbstractHydrogen production through seawater electrolysis faces several challenges, one of which involves the development of electrocatalysts with high catalytic performance. Here, surface amorphization and morphology engineering are combined to design a novel electrocatalyst for highly‐efficient hydrogen evolution reaction (HER). The surface‐amorphized MoO2/Ni3(PO4)2 microcolumns supported on nickel foam (SA‐MoO2/Ni3(PO4)2/NF) display remarkable performance with low overpotentials of 34 and 46 mV at a current density of 10 mA cm−2 in 1 m KOH and alkaline seawater, respectively. In addition, the alkaline electrolysis cell (AEC) integrated with SA‐MoO2/Ni3(PO4)2/NF as the cathode and Ni foam as the anode achieves a current density of 100 mA cm−2 at 1.87 V in 6 m KOH seawater at 60 °C, superior to that of industrial NiMo electrode as cathode (2.05 V). DFT calculations demonstrate that the surface amorphous layer (MoOx) improves the hydrogen adsorption energy of sample and reduces the energy barrier of water dissociation. It is found that substantial improvement in catalytic performance stems from the synergistic effect between surface amorphization and unique microcolumn morphology. These findings may provide insights into combining surface amorphization and morphology engineering strategies to enhance catalytic performance and pave the way for the development of highly efficient seawater HER electrocatalysts.
Mechano‐Activated Cell Therapy for Accelerated Diabetic Wound Healing
Authors: Shou Yufeng , Le Zhicheng , Cheng Hong Sheng , Liu Qimin , Ng Yi Zhen , Becker David Laurence , Li Xianlei , Liu Ling , Xue Chencheng , Yeo Natalie Jia Ying , Tan Runcheng , Low Jessalyn , Kumar Arun R.K. , Wu Kenny Zhuoran , Li Hua , Cheung Christine , Lim Chwee Teck , Tan Nguan Soon , Chen Yongming , Liu Zhijia , Tay Andy 
Published: September 2023

AbstractChronic diabetic wounds are a significant global healthcare challenge. Current strategies, such as biomaterials, cell therapies, and medical devices, however, only target a few pathological features and have limited efficacy. A powerful platform technology combining magneto‐responsive hydrogel, cells, and wireless magneto‐induced dynamic mechanical stimulation (MDMS) is developed to accelerate diabetic wound healing. The hydrogel encapsulates U.S. Food and Drug Administration (FDA)‐approved fibroblasts and keratinocytes to achieve ∼3‐fold better wound closure in a diabetic mouse model. MDMS acts as a nongenetic mechano‐rheostat to activate fibroblasts, resulting in ∼240% better proliferation, ∼220% more collagen deposition, and improved keratinocyte paracrine profiles via the Ras/MEK/ERK pathway to boost angiogenesis. The magneto‐responsive property also enables on‐demand insulin release for spatiotemporal glucose regulation through increasing network deformation and interstitial flow. By mining scRNAseq data, a mechanosensitive fibroblast subpopulation is identified that can be mechanically tuned for enhanced proliferation and collagen production, maximizing therapeutic impact. The “all‐in‐one” system addresses major pathological factors associated with diabetic wounds in a single platform, with potential applications for other challenging wound types.
Photochemically Activated 3D Printing Inks: Current Status, Challenges, and Opportunities
Authors: Gauci Steven C. , Vranic Aleksandra , Blasco Eva , Bräse Stefan , Wegener Martin , Barner‐Kowollik Christopher 
Published: September 2023

Abstract3D printing with light is enabled by the photochemistry underpinning it. Without fine control over the ability to photochemically gate covalent bond formation by the light at a certain wavelength and intensity, advanced photoresists with functions spanning from on‐demand degradability, adaptability, rapid printing speeds, and tailored functionality are impossible to design. Herein, recent advances in photoresist design for light‐driven 3D printing applications are critically assessed, and an outlook of the outstanding challenges and opportunities is provided. This is achieved by classing the discussed photoresists in chemistries that function photoinitiator‐free and those that require a photoinitiator to proceed. Such a taxonomy is based on the efficiency with which photons are able to generate covalent bonds, with each concept featuring distinct advantages and drawbacks.
Chemical Reactions in Living Systems
Authors: Schauenburg Dominik , Weil Tanja 
Published: September 2023

AbstractThe term “in vivo (“in the living”) chemistry” refers to chemical reactions that take place in a complex living system such as cells, tissue, body liquids, or even in an entire organism. In contrast, reactions that occur generally outside living organisms in an artificial environment (e.g., in a test tube) are referred to as in vitro. Over the past decades, significant contributions have been made in this rapidly growing field of in vivo chemistry, but it is still not fully understood, which transformations proceed efficiently without the formation of by‐products or how product formation in such complex environments can be characterized. Potential applications can be imagined that synthesize drug molecules directly within the cell or confer new cellular functions through controlled chemical transformations that will improve the understanding of living systems and develop new therapeutic strategies. The guiding principles of this contribution are twofold: 1) Which chemical reactions can be translated from the laboratory to the living system? 2) Which characterization methods are suitable for studying reactions and structure formation in complex living environments?
Capillary dysfunction in healthy elderly APOE ε4 carriers with raised brain Aβ deposition
Authors: Madsen Lasse S. , Kjeldsen Pernille L. , Ismail Rola , Parbo Peter , Østergaard Leif , Brooks David J. , Eskildsen Simon F. 
Published: September 2023

AbstractINTRODUCTIONCapillary dysfunction, characterized by disturbances in capillary blood flow distribution, might be an overlooked factor in the development of Alzheimer's disease (AD). This study investigated microvascular blood flow in preclinical and prodromal AD individuals.METHODSUsing dynamic susceptibility contrast magnetic resonance imaging and positron emission tomography, we examined alterations in microvascular circulation and levels of Aβ deposition in two independent cohorts of APOE ε4 carriers.RESULTSCapillary dysfunction was elevated in both prodromal and preclinical AD individuals compared to age‐matched controls. Additionally, the prodromal group exhibited higher levels of capillary dysfunction compared to the preclinical group.DISCUSSIONThese findings suggest that capillary dysfunction can be detected at the preclinical stage of AD and indicates a worsening of capillary dysfunction throughout the AD continuum. Understanding the interaction between capillary dysfunction and Aβ could provide insights into the relationship between cardiovascular risk factors and the development of AD.Highlights
Alzheimer's disease (AD) is associated with disturbances in microvascular circulation.
Capillary dysfunction can be detected in preclinical AD.
As cognitive symptoms progress in prodromal AD, capillary dysfunction worsens.
Capillary dysfunction may impede the clearance of beta‐amyloid (Aβ).
Capillary dysfunction might contribute to the development of AD.