bluuebunny/crossref_metadata_2025_split huggingface dataset:
Role of Oxalic Acid in Expression of Resistance against the Pod Borer Helicoverpa armigera (Lepidoptera: Noctuidae) in Chickpea Varieties
Authors: Mishra Yogendra Kumar , Sharma Amit Kumar , Sondhia Shobha , Ramakrishnan R. Shiv , Panday A.K. , Gharde Yogita , Singh Sanjay 
Published: December 2022

Background: Pod borer is most serious problem to cultivation of chickpea across the world. In India, Madhya Pradesh rank first in both area and production of chickpea. This region is considered most affected yield of chickpea due to H. armigera. Host plant resistance is an important component for managing this pest. To develop cultivars with resistance to insects, it is important to understand the role of oxalic acid associated with resistance to this pest. The current study aimed to study the role of oxalic acid in expression of resistance against the pod borer Helicoverpa armigera (Lepidoptera: Noctuidae) in chickpea varieties under climate change. Methods: This investigation was carried out at Research Farm of Soybean Seed Production-Unit, College of Agriculture, JNKVV (MP) during Rabi season 2019-20 and 2020-21. The field experiment was laid out in split split plot design with 24 treatments and three replications. The treatments included three date of sowing i.e. 15th November, 30th November and 15th December as a main plots, two irrigation levels i.e. I0-no irrigation and I1- irrigation at 35 DAS as a sub plots and four chickpea varieties i.e. JG 12, JG 36, JG 14 and JG 24 as sub sub plots. The observation on number of eggs and larval population of H. armigera were recorded from one-meter row length (mrl). At five randomly selected places were averaged separately for each plot and made in to number of eggs and larval population per meter row length (mrl). The amount of oxalic acid in chickpea leaves was determined by UFLC method. The correlation was worked out with population of pod borer and amount of oxalic acid in chickpea varieties. Result: In this investigation, the ultra-fast liquid chromatography (UFLC) profiles of the leaf exudates of chickpea varieties exhibited amounts of oxalic acid significantly negative correlation with egg count and larvae incidence of H. armigera.
Redistribution of gas between the bulk and bubble phases in water irradiated with low-intensity electromagnetic waves
Authors: Almazova Оlena , Lysychenko Mykola 
Published: December 2022

It has been established that the irradiation of liquid water with low-intensity electromagnetic waves of the centimeters range provides:

Increasing the amount of light scattering (and optical density) of the water sample.
An increase in the volume of free air contained in the water.

These changes are due to the transfer of part of the gas dissolved in water into air bubbles.
The mechanism "bubble" can explain the effects of low-intensity electromagnetic waves on biological fluids. Also, a change in the "standard" mode of functioning of a living cell. Figs.:1, Tabl.: , Refs.: 18 titles.
Keywords: electromagnetic waves, irradiation, air bubbles.
Method for determining the levels of detail of spatial objects as part of a three-dimensional information model of an urban area
Authors: Honcharenko Tetyana 
Published: December 2022

The article proposes a method for determining the levels of detail for spatial objects, which is part of the three-dimensional information model of the urban area in order to reduce the computational load in operations related to visualization. The method adapts the concept of multi-level detailing to the list of spatial objects of the urban territory, where ranges of levels of detail are chosen for each of them, based on the needs of different management subjects when making decisions in emergency situations. Figs.: 4. Refs.: 14 titles.
Keywords: information model of the urban area, modeling of spatial objects, levels of detail, LoD; CityGML.
Generation of parallel colocation difference schemes using the integro-interpolation approach
Authors: Dmitrieva Olga , Huskova Vira 
Published: December 2022

The issues of development of stable parallel difference schemes of a given order of accuracy, focused on the discretization of differential equations or their systems with concentrated and distributed parameters using an integro-interpolation approach to the generation of calculation coefficients, are considered. The proposed difference schemes improve the efficiency of parallel simulation and optimization of dynamic processes described by evolution equations with distributed parameters. Such equations are characterized by the absence of analytical solutions. The introduction of higher-order derivatives into difference schemes improves the accuracy of the obtained results and equalizes the approximation orders for all calculation points in the block.The proposed approach is universal for obtaining difference equations of various types. The computational formulas obtained on the basis of this approach for multipoint difference equations have less computational complexity and are oriented to implementation in computing systems with a parallel architecture.
Keywords: integro-interpolation approach, difference schemes, colocation block methods, parallel computing
Diagnosis and monitoring of a person's psychophysiological state based on multidimensional transient functions of the oculo-motor system
Authors: Pavlenko Vitaliy , Shamanina Tatiana , Chori Vladyslav 
Published: December 2022

An important scientific and practical problem has been solved, which consists in the creation of methods and tools for nonlinear dynamic identification "input-output" of the human oculomotor system (OMS). Identification is carried out based on Volterra models in the form of multidimensional transient functions (n-dimensional integrals from Volterra kernels) using innovative eye tracking technology. As test signals, visual stimuli are used, which are displayed on the monitor screen at different distances from the starting position, which formally corresponds to the action of step signals with different amplitudes at the OMS input. Experimental studies of the OMS of individuals were carried out using the Tobii Pro TX300 eye tracker. The transient functions of the first and diagonal intersections of the transient functions of the second and third order were determined based on the data of oculographic studies. The models differ from the known ones in that they provide the possibility of modeling the OMS in each interval of input signals beyond the radius of convergence of the Volterra series. The obtained multidimensional functions are used as a source of primary data in the implementation of intelligent information technology for the diagnosis and monitoring of human psychophysiological states. A set of heuristic features are proposed, which are determined using integral and differential transformations of the obtained transient functions of the OMS. The informativeness of individual signs and all their possible combinations in pairs according to the indicator of the probability of correct recognition was studied. The research results were obtained using the construction of Bayesian classifiers in different spaces of the proposed features. Figs.: 2. Refs.: 15 titles.
Keywords: psychophysiological state, diagnosis, monitoring, oculo-motor system, identification, Volterra model, multidimensional transient functions, test visual stimuli, eye-tracking technology
Reflexões sobre a indissociabilidade do ensino, pesquisa e extensão a partir do projeto de ensino no curso técnico integrado ao ensino médio
Authors: Ribeiro Eduardo , Boligian Levon , Reinert Marcos 
Published: December 2022

O presente relato de experiência abordará impressões de um projetos de ensino executado na disciplina de Geografia dos primeiros anos dos cursos técnico integrado ao ensino médio no campus de São Francisco do Sul do Instituto Federal Catarinense (IFC) com o tema CENSO 2022. O projeto também propiciou vivenciar as etapas de uma pesquisa de campo e a realização de um evento de extensão. Todas as ações em sintonia com a discussão teórica sobre a indissociabilidade do ensino, pesquisa e extensão. Além de pontuar os referenciais teóricos que fundam este princípio, este relato também aborda a diferença entre a natureza de um projeto de ensino de um projeto integrado. O projeto de ensino é uma iniciativa pedagógica interessante e não é exclusiva a educação profissional e tecnológica. A experiência deve ser mais discutida e vivenciada no ensino básico como um todo.
Hyperlocal super-learned PM2.5 components across the contiguous US
Authors: Amini Heresh , Danesh-Yazdi Mahdieh , Di Qian , Requia Weeberb , Wei Yaguang , Abu-Awad Yara , Shi Liuhua , Franklin Meredith , Kang Choong-Min , Wolfson Jack , James Peter , Habre Rima , Zhu Qiao , Apte Joshua , Andersen Zorana , Xing Xiaoshi , Hultquist Carolynne , kloog Itai , Dominici Francesca , Koutrakis Petros , Schwartz Joel 
Published: December 2022

Abstract
Particulate matter with aerodynamic diameter less than 2.5 μm (PM2.5) increases mortality and morbidity.1,2 PM2.5 is composed of a mixture of chemical components that vary across space and time.3 Due to limited hyperlocal data availability, less is known about health risks of PM2.5 components, their US-wide exposure disparities, or which species are driving the biggest intra-urban changes in PM2.5 mass. Here, we developed the first national super-learned models across the US for hyperlocal estimation of annual mean elemental carbon (EC), ammonium (NH4+), nitrate (NO3-), organic carbon (OC), and sulfate (SO42-) concentrations across 3,535 urban areas at a 50-m spatial resolution, and at a 1-km resolution for non-urban areas from 2000 to 2019. Using ensembles of machine learning models and ~82 billion predictions across 20 years, hyperlocal super-learned PM2.5 components are now available for further research. We found remarkable spatiotemporal intra-urban and inter-urban variabilities in PM2.5 components. We anticipate our work to be a critical milestone for conducting new studies on individual and combined health risks of PM2.5 components, environmental justice analysis, or understanding fine-scale spatiotemporal variabilities of PM2.5 composition. Urban planners and regulators may also use these predictions for selecting locations of new daycares, schools, nursing homes, or air-quality monitors.
American Jatropha curcas L. accessions for crop improvement in biodiesel Production
Authors: Teco-Bravo Jalsen Iván , Mijangos-Cortés Javier Orlando , Barahona-Pérez Luis F. , Navarrete-Yabur Abelardo , Tovar-Juárez Edgar 
Published: December 2022

Abstract
In this study, the variation of morphological and agronomic characters of 10 accessions of J. curcas selected from Yucatan, Mexico, and Honduras was analyzed. The characters associated with the proportions of the plants (height, number, and length of branches), the fruits (diameter and thickness), and the seeds (length, width, and volume), as well as those associated with the agronomic yield (number and yield of seeds plant− 1), explained the greatest variation between the accessions, 40 and 24%, respectively. The CAM32 and GAGI10 accessions had the lowest vegetative proportions and the highest agronomic yield, SUCILATEBEC and B5F59P19 had the lowest proportion and low yield, B3F119P1 had the highest proportion and high oil content, but low yield; while B5F83P1 had high values of vegetative proportions, and agronomic performance. The characters with the greatest variation among the accessions were ABM (59.93%), WV (56.91%), NS plant− 1 (57.18%), the SY plant− 1 (55.49%), and NL (54.37%). The similarity analysis grouped the accessions that had in common the geographical origin and the magnitudes of the characters associated with the agronomic performance and with the proportions of the plants, fruits, and seeds. The present study allowed the identification of J. curcas accessions with desirable agronomic and morphological traits, such as seed yield, oil content, and plant height, which can serve as progenitors in breeding programs for this species.
The relationship between the neck and low back pain in association with gender
Authors: Baygutalp Fatih , Urak Faruk , Bilgic Abdulbaki , Kul Ayhan 
Published: December 2022

Abstract
Background: There are very few large population studies in Turkey that evaluate the risk factors associated with low back and neck pain in terms of gender. This study aimed to reveal the determinants of the co-occurrence of low back pain (LBP) and neck pain (NP) in terms of gender by synthesizing evidence regarding the risk factors of LBP and NP disease burden.
Methods: The study obtains the up-to-date 2019 Turkey Health Survey data from the Turkish Statistical Institute and covers 8163 families with 16253 individuals aged 18 and older. The dependent variable consisted of those who had neither LBP nor NP, had one, and had both, within the last 12 months using the random-effects ordered probit model.
Results: The 1-year total prevalence of LBP and/or NP in the Turkish population in 2019 was 39.49%. The dual burden of disease was 2.34 times higher in women than in men. In both sexes, the prevalence of dual disease increased significantly with increasing age and in the presence of severe obesity (P<0.05). When double disease prevalence in women compared with men, it was investigated that it was 2.49 times less common in unmarried people, 1.76 times less in those with a bachelor's degree, 1.79 times less in those who walked for more than an hour a day, and 2.83 times less in those who consumed one meal or more of fruit a day. As the monthly income of women increases, the probability of having a double disease decreases by 2.2 times compared to the probability of contracting a single disease. However, when the prevalence of double disease in women was compared with men, it was 3.94 times higher for the employed, 6 times higher for smokers, and 1.5 times higher for those with depression.
Conclusions: By disaggregating the data according to gender, statistical relationships between each group's LBP and NP burden and some risk factors were revealed to facilitate the treatment of modifiable risk factors.
Management of Large conjunctival cysts in a patient with Stevens-Johnson syndrome; a case report and review of the literature
Authors: Hooshmandi Sadid , Hassanpour Kiana , Veisi Amirreza , Movafaghi Vahid , Sadoughi Mohammad-Mehdi , Javadi Mohammad Ali 
Published: December 2022

Abstract
Background: To report the management of a patient with two conjunctival cysts as a late Stevens-Johnson syndrome (SJS) sequela. SJS is a life-threatening mucocutaneous disease with various etiologies including drugs, infections, and malignancies. Ocular manifestations of SJS vary from the membrane, symblepharon formation, and epithelial defect in the acute phase totrichiasis, eyelid margin keratinization, and lacrimal duct obstruction in the chronic phase.
Case presentation: A 13-year-old boy with a history of drug-induced SJS presented to our clinic complaining of a mass in the nasal side and inferior fornix of the right eye from 1 year ago. The mass-like lesion in the medial side of the right eye was accompanied by ankyloblepharon, symblepharon, and ptosis and limited ocular movement. Orbital imaging showed cystic lesions on the medial side of the right globe and the inferior fornix.
Two large cysts were entirely surgically excised. Histopathologic investigation revealed conjunctival tissue with nonkeratinized epithelium and goblet cells. There was no sign of conjunctival cyst recurrence or symblepharon formation on the 6th-month follow-up. The inferior fornix achieved acceptable depth and the ocular movements became normal.
Conclusion: Spontaneous conjunctival cysts may occur in SJS and should be managed carefully to improve the ocular surface and movements.
High-protein beverages, the impact on normalized protein catabolic rate and inflammation markers in a hemodialysis population: A study protocol for a double-blind randomized crossover design trial
Authors: Aycart Danielle Francesca , Andrade Jeanette 
Published: December 2022

Abstract
Background: Chronic kidney disease is considered a silent killer compared to more prominent non-communicable diseases such as cardiovascular disease and diabetes. In the final stage of this disease, end-stage kidney disease (ESKD), inflammation attributed to the presence of cytokines, acidosis and oxidative stress ensues, which contributes to other complications such as protein-energy wasting. In recent years, the kidney community has been focused on reducing this inflammation by recommending plant proteins compared to animal proteins. However, there is a lack of randomized clinical trials in the ESKD population, thus, recommendations of which proteins to consume are mixed.
Methods: A 12-week interventional, double-blind randomized controlled crossover clinical trial will be conducted to evaluate the impact 135g of whey (control) and 135g of soy (intervention) protein isolate beverages on protein status and inflammation in adults on hemodialysis. A simple randomization method will indicate which protein source the participants will receive first. Baseline data collections will be conducted after participant allocation but before the participant consumes the beverage. The first beverage will be provided to the participants after every dialysis treatment for 4-consecutive weeks. The participants will then have a 4-week washout period to avoid carryover effect. After the washout period has concluded, the second beverage will be provided for 4-consecutive weeks. The primary outcome is impact on inflammation as detected by serum C-reactive protein from baseline to post-intervention. Secondary outcomes are the differences in estimated normalized protein catabolic rate and interleukin 6. Exploratory outcomes include detection in amino acids, differences in uremic toxins, dietary habits as identified through a food frequency questionnaire and malnutrition as detected by the malnutrition inflammation scores from baseline to post-intervention.
Discussion: If the soy protein isolate beverage improves protein status and reduces inflammation, this study will have major clinical implications for providing plant-based proteins within the ESKD population to help mitigate complications.
Trial registration: This study was registered in ClinicalTrial.gov on February 7, 2022, identifier NCT05227755.
Pharmacokinetic and safety analysis of biosimilar adalimumab in healthy volunteers in Bangladesh
Authors: Kulsum Umme , Azad Kasrina , Washif Mubasshir , Hossain Mohabbat , Sultana Nishat , Hossain Ismail , Ahmed Faez , Rahman Ridwanur , Muktadir Abdul , Muktadir Hasneen , Karim Mahbubul , Rahman Mohammad Mizanur , Hossain Md Shawkat , Monim Syed Abdul , Panday Alex S. , Qadri Firdausi , Kawser Zannat 
Published: December 2022

Abstract
Aims
Advixa is a monoclonal antibody manufactured as a biosimilar to adalimumab (Humira, Abbvie Inc.). The key objectives of this study were to use a healthy population group to assess pharmacokinetics (PK) and safety similarity between Advixa and Humira in healthy participants and to quantify the effects of potential covariates on adalimumab PK and safety to assess the impact of treatment with Advixa.
Methods
A group of healthy participants selected by screening aged between 18 and 45 years. According to the randomization table, each participant was given Adalimumab (Advixa and Humira) in the inpatient facilities in a hospital and observed for 72 hours. Several blood samples were collected from the participants at different time points up to day 64 to measure their Pharmacokinetics and biosimilarity.
Results
The serum concentration-time profiles for PK and safety were compared in this randomized, double-blinded study between Humira and Advixa. A review of the data for biosimilarity confirmed that these products are similar to each other regarding healthy participants. 90% confidence interval of the relative mean Cmax, AUC0-t, and AUCo-inf of the Advixa and Humira were found within the acceptance criteria. No differences in safety profiles were observed in these studies.
Conclusion
PK and safety are similar between Advixa and Humira in participants with healthy status demonstrated in this clinical trial (NCT05172817; Registration Date/Initial Release Date: 28/09/2021). Adalimumab PK was also similar to treatment with Humira and Advixa.
Dual novel homozygous mutations in ISG15 and MPO lead to classic type I interferonopathy and a new phenotype of recurrent parenchymal pneumonia
Authors: Xu Qiling , Li Wenyan , zhao Qian , Lv Ge , Sun Gan , Gao Yelei , Ding Yuan , Zhang Zhiyong , Zhou Lina , Tang Xuemei , Zhao Xiaodong , An Yunfei 
Published: December 2022

Abstract
Purpose
ISG15 deficiency, a rare human inborn error of immunity characterized by susceptibility to Mycobacterium tuberculosis infection, shows neuropathic and dermatological manifestations. MPO deficiency is a common inherited defect of phagocytes, but it is not classified as an independent primary immune deficiency due to lack of clinical symptoms. Dual mutation of ISG15 and MPO has not been reported.
Methods
We analyzed the clinical, genetic, and immunological features of two siblings with ISG15 deficiency combined with MPO mutations, and explored therapeutic candidates.
Results
The major manifestation observed in patient 2 was necrotic skin lesions, while those in patient 1 were intracranial calcification and recurrent pneumonia. Whole-exome sequencing indicated novel, dual mutations in ISG15 and MPO, leading to lack of ISG15 expression and reduced MPO expression. PBMCs and B-cell lines derived from the patients showed hyperactivated JAK/STAT signaling and elevated oxidative stress. A "False-Positive" DHR test for MPO was reversed by exogenous peroxidase. RNA sequencing analyses identified baricitinib as an available therapeutic candidate for hyper-inflammation associated with ISG15 deficiency.
Conclusions
We reported two sibling patients with the same novel ISG5 mutation combined with partial MPO deficiency. These patients showed different presentations, and one of them harbored a new phenotype of recurrent pneumonia. These findings expand the clinical spectrum of ISG15 deficiency, reinforce its diversity, and identify a potential therapeutic candidate for this rare disease.
Simultaneous adsorption of Amoxicillin and Cefixime by facile synthesized Chitosan@Polyacrylamide@ZIF-8; Isotherm and Kinetic study
Authors: Zadvarzi saber Babaee , Amooey Aliakbar 
Published: December 2022

Abstract
In recent years, drug use around the world due to population growth and the spread of disease is increasing these include antibiotics which account for about 10 to 15% of drug use. The studies show that antibiotics have a permanent and destructive effect on the environment which not completely removed in refineries. In this study, the Chitosan@Polyacrylamide@ZIF-8 as an adsorbent was simultaneously used to removal of Cefixime and Amoxicillin from the aqueous solution by adsorption method. XRD and FTIR patterns were analyzed for investigation of the surface crystallinity and the chemical properties of the adsorbent. In the following, SEM and TEM images were used for surface morphology study. Finally, a numerical investigation have been done for predicting the adsorption effective parameters. The results show that pH 4, contact time 30 minutes, initial concentration 50 mg/L, temperature 25° C and 15 mg of adsorbent are optimal condition which removal percentage achieved up to %90. The Langmuir, Friendlich, Tamkin, and Dubinin-Radushkovich isotherms were examined by experimental data and Langmuir model presented the best consistency with the experimental results and the maximum calculated adsorption capacity for Amoxicillin and Cefixime are 910 mg/g and 588 mg/g, respectively. Pseudo-first order, Pseudo-second order and intra-particle diffusion were investigated for kinetic studies. The results of the calculations illustrated the Pseudo second order model has been dominant. Overall, this study expresses, Chitosan@Polyacrylamide coated by ZIF-8 can be used an appropriate, effective and economical adsorbent for the adsorption of Amoxicillin and Cefixime.