bluuebunny/crossref_metadata_2025_split huggingface dataset:
Flying cars economically favor battery electric over fuel cell and internal combustion engine
Authors: Liu Ming , Hao Han , Lin Zhenhong , He Xin , Qian Yuping , Sun Xin , Geng Jingxuan , Liu Zongwei , Zhao Fuquan 
Published: March 2023

Abstract
Flying cars, essentially vertical takeoff and landing aircraft (VTOL), are an emerging, disruptive technology that is expected to reshape future transportation. VTOLs can be powered by battery electric, fuel cell, or internal combustion engine, which point to entirely different needs for industry expertise, research & development, supply chain, and infrastructure supports. A pre-analysis of the propulsion technology competition is crucial to avoid potential wrong directions of research, investment, and policy making efforts. In this study, we comprehensively examined the cost competitiveness of the three propulsion technologies. Here we show that battery electric has already become the lowest-cost option for below-200-km VTOL applications, covering intra-city and short-range inter-city travels. This cost advantage can be robustly strengthened in the long term under various technology development scenarios. Battery energy density improvement is the key to reducing cost. In particular, a 600 Wh/kg battery energy density provides battery electric with all-range cost advantage, and promises high return in business. Fuel cell and internal combustion engine, under certain technology development scenarios, can obtain cost advantage in long-range applications, but face intense competition from ground transportation such as high-speed rail. The findings suggest a battery-electric-prioritized VTOL development strategy, and the necessity of developing VTOL-customized high-energy-density batteries.
Management of systemic sclerosis: British Society for Rheumatology guideline scope
Authors: Denton Christopher P , De Lorenzis Enrico , Roblin Elen , Goldman Nina , Alcacer-Pitarch Begonya , Blamont Emma , Buch Maya , Carulli Maresa , Cotton Caroline , del Galdo Francesco , Derrett-Smith Emma , Douglas Karen , Farrington Sue , Fligelstone Kim , Gompels Luke , Griffiths Bridget , Herrick Ariane , Hughes Michael , Pain Clare , Pantano Georgina , Pauling John , Prabu Athiveeraramapandian , O’Donoghue Nuala , Renzoni Elisabetta , Royle Jeremy , Samaranayaka Muditha , Spierings Julia , Tynan Aoife , Warburton Louise , Ong Voon 
Published: March 2023

AbstractThis guideline will provide a practical roadmap for management of SSc that builds upon the previous treatment guideline to incorporate advances in evidence-based treatment and increased knowledge about assessment, classification and management. General approaches to management as well as treatment of specific complications will be covered, including lung, cardiac, renal and gastrointestinal tract disease, as well as RP, digital vasculopathy, skin manifestations, calcinosis and impact on quality of life. It will include guidance related to emerging approved therapies for interstitial lung disease and account for National Health Service England prescribing policies and national guidance relevant to SSc. The guideline will be developed using the methods and processes outlined in Creating Clinical Guidelines: Our Protocol. This development process to produce guidance, advice and recommendations for practice has National Institute for Health and Care Excellence accreditation.
The diagnostic value of urinary N-terminal fragment of titin for skeletal muscle damage in idiopathic inflammatory myopathy
Authors: Sun Jianhong , Ye Sheng , Yin Geng , Xie Qibing 
Published: March 2023

Abstract

Objectives
N-terminal fragment of titin (N-titin) is a marker of sarcomere damage in striated muscles; however, its value in patients with IIM (idiopathic inflammatory myopathy) is unclear. This study aimed to investigate the diagnostic value of N-titin for skeletal muscle damage in patients with IIM.

Methods
Urine samples from 62 patients with IIM, 59 patients with other CTD diseases, and 29 healthy controls were collected to detect N-titin by ELISA assays. Clinical features and laboratory data were all included in logistic regression analysis to obtain the independent predictive factor for skeletal muscle damage.

Results
Urinary N-titin level of the IIM group [168.3 (19.0, 1279.0) pmol/mg cr] was significantly higher than that in CTD controls [2.80 (1.53, 3.60)] and healthy controls [1.83 (1.09, 2.95)] (P &lt; 0.001). IIM patients with skeletal muscle injury had a significantly higher level of urinary N-titin [1001.0, (181.8, 1977.0)] than those without [9.3, (5.8, 23.9)] (P &lt; 0.001). The N-titin level was strongly correlated with CK (r = 0.907, P &lt; 0.001) and muscle disease activity assessment scores by Spearman correlation analysis. After adjusting for the anti-MDA5 antibody and cardiac troponin T, N-titin was shown to independently predict skeletal muscle damage in patients with IIM (odds ratio = 1.035, 95% CI: 1.002, 1.069, P = 0.039). The cut-off value of urinary N-titin to diagnose skeletal muscle damage was 89.9 pmol/mg Cr, with a sensitivity of 87.8% and a specificity of 100% (AUC = 0.971, 95% CI: 0.938, 1.000, P &lt; 0.001).

Conclusion
Urinary N-titin is a non-invasive and independent predictive factor for determining skeletal muscle damage in patients with IIM.
Genetics of longitudinal kidney function in children and adults with systemic lupus erythematosus
Authors: Tang Thai-Son , Liao Fangming , Webber Declan , Gold Nicholas , Cao Jingjing , Dominguez Daniela , Gladman Dafna , Knight Andrea , Levy Deborah M , Ng Lawrence , Paterson Andrew D , Touma Zahi , Urowitz Murray B , Wither Joan , Silverman Earl D , Pullenayegum Eleanor M , Hiraki Linda T 
Published: March 2023

Abstract

Objectives
Genome-wide association studies (GWAS) have identified loci associated with estimated glomerular filtration rate (eGFR). Few LN risk loci have been identified to date. We tested the association of SLE and eGFR polygenic risk scores (PRS) with repeated eGFR measures from children and adults with SLE.

Methods
Patients from two tertiary care lupus clinics that met ≥4 ACR and/or SLICC criteria for SLE were genotyped on the Illumina MEGA or Omni1-Quad arrays. PRSs were calculated for SLE and eGFR, using published weighted GWA-significant alleles. eGFR was calculated using the CKD-EPI and Schwartz equations. We tested the effect of eGFR- and SLE-PRSs on eGFR mean and variance, adjusting for age at diagnosis, sex, ancestry, follow-up time, and clinical event flags.

Results
We included 1158 SLE patients (37% biopsy-confirmed LN) with 36 733 eGFR measures over a median of 7.6 years (IQR: 3.9–15.3). LN was associated with lower within-person mean eGFR [LN: 93.8 (s.d. 26.4) vs non-LN: 101.6 (s.d. 17.7) mL/min per 1.73 m2; P &lt; 0.0001] and higher variance [LN median: 157.0 (IQR: 89.5, 268.9) vs non-LN median: 84.9 (IQR: 46.9, 138.2) (mL/min per 1.73 m2)2; P &lt; 0.0001]. Increasing SLE-PRSs were associated with lower mean eGFR and greater variance, while increasing eGFR-PRS was associated with increased eGFR mean and variance.

Conclusion
We observed significant associations between SLE and eGFR PRSs and repeated eGFR measurements, in a large cohort of children and adults with SLE. Longitudinal eGFR may serve as a powerful alternative outcome to LN categories for discovery of LN risk loci.
UK experience of professional registration in radiation protection
Authors: Chapple Claire-Louise , Marsden Peter J , Rankine Alex 
Published: March 2023

Abstract
The UK Radiation Protection Council (RPC) was established in 2019, under the Royal Charter of the Society for Radiological Protection. The RPC holds the registers for three grades of professional registration—Chartered, Incorporated and Technical Radiation Protection Professional. Individual radiation protection practitioners may apply for registration through any society or organisation that has been accepted as a Licensee of the RPC. This paper will give an overview of the criteria used for registration at each level, along with the benefits of professional registration to individuals, employers, the radiation protection profession and the public. We will discuss the operation of the RPC and share the experience of its establishment, identifying key issues and potential pitfalls for other Societies wishing to go down this route. Future expectations for professional registration will be considered.
The Difficulties of Grandiose Delusions: Harms, Challenges, and Implications for Treatment Engagement
Authors: Isham Louise , Loe Bao Sheng , Hicks Alice , Wilson Natalie , Bentall Richard P , Freeman Daniel 
Published: March 2023

AbstractBackground and HypothesisGrandiose delusions may entail difficult responsibilities and detrimental actions for patients. Recognition of these consequences by patients may provide an avenue for engagement in treatment. Furthermore, when patients carry out actions within the delusional system (“immersion behaviors”) or spend considerable time thinking about their grandiose beliefs this may contribute to the persistence of the grandiosity and further harmful consequences. We, therefore, investigated grandiose-related subjective harm, immersion behaviors, and perseverative thinking.Study DesignA cross-sectional study with 798 patients with psychosis (375 of whom had grandiose delusions) and 4518 nonclinical adults. Factor analyses using data from participants scoring highly on grandiosity were used to form 3 scales: subjective harm from exceptional experiences questionnaire; immersion behaviors questionnaire; and thinking about exceptional experiences questionnaire. Associations with grandiosity were tested using structural equation modeling.Study ResultsA total of 268 (77.9%) patients with grandiose delusions identified grandiose-related harms in the past 6 months and 199 (55.1%) wanted help. Immersion behaviors and perseverative thinking were highly prevalent, and explained 39.5% and 20.4% of the variance in grandiosity, respectively. Immersion behaviors and perseverative thinking were significantly associated with subjective harm, even when severity of grandiosity was controlled. Requests for help were associated with higher levels of subjective harm, use of immersion behaviors, and perseverative thinking but not severity of grandiosity.ConclusionsActing on grandiose delusions, including harmful behaviors and excessive thinking about grandiose delusions, may be routes for clinicians to engage patients in treatment. This could be a starting point for targeted psychological interventions for grandiose delusions.
Boundary work in the regional innovation policy mix: SME digital technology diffusion policies in Wales
Authors: Henderson Dylan 
Published: March 2023

Abstract
In recent decades, research has begun to examine the concept of the regional policy mix and its implications for regional innovation. While this has highlighted the role of interactions between multilevel policy instruments and the potential for duplication and synergies, it has tended to underplay the contribution of policy actors to managing such policy mix processes. This paper seeks to add to this literature by introducing the concept of boundary work, viewing it as a form of agency practice seeking to create, maintain, and disrupt instruments within the policy mix. Through a case study of digital technology diffusion instruments in Wales (UK), this paper examines the actors, practices, and effects of boundary work in the regional policy mix. The findings show that boundary work can help manage tensions in the policy mix through anticipatory practices but that complexity and uncertainty in the regional innovation policy mix present ongoing challenges to policymakers.
Natural selection differences detected in key protein domains between non-pathogenic and pathogenic feline coronavirus phenotypes
Authors: Zehr Jordan D , Kosakovsky Pond Sergei L , Millet Jean K , Olarte-Castillo Ximena A , Lucaci Alexander G , Shank Stephen D , Ceres Kristina M , Choi Annette , Whittaker Gary R , Goodman Laura B , Stanhope Michael J 
Published: March 2023

AbstractFeline coronaviruses (FCoVs) commonly cause mild enteric infections in felines worldwide (termed feline enteric coronavirus [FECV]), with around 12 per cent developing into deadly feline infectious peritonitis (FIP; feline infectious peritonitis virus [FIPV]). Genomic differences between FECV and FIPV have been reported, yet the putative genotypic basis of the highly pathogenic phenotype remains unclear. Here, we used state-of-the-art molecular evolutionary genetic statistical techniques to identify and compare differences in natural selection pressure between FECV and FIPV sequences, as well as to identify FIPV- and FECV-specific signals of positive selection. We analyzed full-length FCoV protein coding genes thought to contain mutations associated with FIPV (Spike, ORF3abc, and ORF7ab). We identified two sites exhibiting differences in natural selection pressure between FECV and FIPV: one within the S1/S2 furin cleavage site (FCS) and the other within the fusion domain of Spike. We also found fifteen sites subject to positive selection associated with FIPV within Spike, eleven of which have not previously been suggested as possibly relevant to FIP development. These sites fall within Spike protein subdomains that participate in host cell receptor interaction, immune evasion, tropism shifts, host cellular entry, and viral escape. There were fourteen sites (twelve novel sites) within Spike under positive selection associated with the FECV phenotype, almost exclusively within the S1/S2 FCS and adjacent to C domain, along with a signal of relaxed selection in FIPV relative to FECV, suggesting that furin cleavage functionality may not be needed for FIPV. Positive selection inferred in ORF7b was associated with the FECV phenotype and included twenty-four positively selected sites, while ORF7b had signals of relaxed selection in FIPV. We found evidence of positive selection in ORF3c in FCoV-wide analyses, but no specific association with the FIPV or FECV phenotype. We hypothesize that some combination of mutations in FECV may contribute to FIP development, and that it is unlikely to be one singular ‘switch’ mutational event. This work expands our understanding of the complexities of FIP development and provides insights into how evolutionary forces may alter pathogenesis in coronavirus genomes.
Molecular phylogeny and taxonomy of three anaerobic plagiopyleans (Alveolata: Ciliophora), retrieved from two geographically distant localities in Asia and North America
Authors: Li Ran , Zhuang Wenbao , Feng Xiaochen , Al-Farraj Saleh A , Schrecengost Anna , Rotterova Johana , Beinart Roxanne A , Hu Xiaozhong 
Published: March 2023

Abstract
Anaerobic ciliates are key organisms for studying adaptations to an anaerobic lifestyle, the evolution of eukaryotic cell organelles, mechanisms of energy metabolism, and symbiosis with prokaryotes; however, the biodiversity of their marine representatives remains poorly known. In this study, three species of ciliates belonging to the class Plagiopylea, i.e. Trimyema foissnerisp. nov.,Plagiopyla rarisetasp. nov., and Plagiopyla frontata, collected from various marine anoxic habitats from two geographically distant continents, Asia and North America, were investigated using morphological and molecular methods. Trimyema foissneri can be recognized by three complete somatic ciliary girdles, special arrangement of kinetosomes near the anterior end of the oral kineties, and the presence of a ventrolateral fragment. Plagiopyla rariseta is distinguished by sparse cilia on the frontal region and particular orientation of the buccal cavity. Plagiopyla frontata is newly recorded and is redescribed in detail and redefined based on new populations. Phylogenetic analyses based on the small subunit ribosomal ribonucleic acid (SSU rRNA) gene supported the generic assignment of the three species and corroborated the monophyly of the families Trimyemidae and Plagiopylidae. An improved key to the identification of the valid species of genus Trimyema is also supplied.
Development of Glycine max Germplasm Highly Resistant to Sclerotinia sclerotiorum
Authors: Webster Richard W. , McCaghey Megan , Mueller Brian D. , Groves Carol L. , Mathew Febina M. , Singh Asheesh K. , Kabbage Mehdi , Smith Damon L. 
Published: March 2023

Sclerotinia stem rot (SSR) of soybean caused by Sclerotinia sclerotiorum is a devastating disease of soybean, especially in the Upper Midwest region of the United States. To mitigate yield losses due to this disease, many control methods are available for producers, including cultural control practices, chemical control, and cultivars with quantitative resistance. However, due to there being few commercial cultivars with high levels of resistance, producers are often limited in their seed selection. The aim of this study was to develop novel conventional soybean cultivars with high levels of resistance to SSR, favorable agronomic traits, and resistance to additional economically important diseases. Initial crosses were conducted in 2016 with two different sources of SSR resistance. Across multiple generations of screening for resistance to SSR, three highly resistant soybean lines were identified as the elite lines. These elite lines were demonstrated to be highly resistant across multiple years in both greenhouse and field trials, including high levels of resistance to multiple diverse S. sclerotiorum isolates. The three selected elite lines also resulted in moderately high yields and favorable agronomic traits, such as low lodging and moderate branching, indicating their viability to be released for production. In addition to SSR resistance, these three elite lines demonstrated resistance to other economically important soybean diseases, such as frogeye leaf spot, anthracnose, Cercospora leaf blight, and brown stem rot. Overall, this work has led to three SSR-resistant soybean lines that could be useful for future breeding efforts or commercial soybean production. [Formula: see text] Copyright © 2023 The Author(s). This is an open access article distributed under the CC BY-NC-ND 4.0 International license .
The #ObGynInternChallenge: Reach, Adoption, Implementation, and Effectiveness of a Microlearning SMS-Distributed Curriculum
Authors: Cai Fei , Santiago Sarah , Southworth Elizabeth , Stephenson-Famy Alyssa , Fay Emily , Wang Eileen Y. , Burns R. Nicholas 
Published: March 2023

Problem
While many medical schools have implemented bootcamps or specialized curricula to prepare medical students for residency, these programs are neither universal nor consistent in their content.

Approach
The authors created an electronic, multimodal, short messaging service (SMS)-distributed curriculum, called the #ObGynInternChallenge, to improve learners’ medical knowledge, based on the Council on Resident Education in Obstetrics and Gynecology educational objectives. The curriculum was open to all fourth-year medical students who matched into obstetrics and gynecology (Ob/Gyn). Daily messages were delivered to participants’ mobile devices via SMS for 25 consecutive weekdays, May 3–June 4, 2021. Each day’s message included an introduction with key facts, an infographic, a website link with a podcast and additional reference materials, and at least one question. The authors assessed its reach, adoption, implementation, and effectiveness.

Outcomes
For reach and adoption, total enrollment for the curriculum was 1,057 (72.0%) of 1,469 filled Ob/Gyn residency positions in the 2021 Match. The total cost of the intervention was $2,503.20 or $2.37 per participant. For implementation, all participants who signed up for the course received the daily messages, and 858/1,057 (81.2%) completed the course. Participants felt the curriculum was an excellent resource for studying (391/426, 91.8%) and the course was enjoyable to use (395/424, 93.2%). For effectiveness, mean score improvement was 11.6% (pre-test: 62.4%, post-test: 74.0%; P < .001). In the multivariate linear regression analysis, high podcast (P = .02) and website use (P = .002) were associated with greater score improvement. High social media use was associated with less improvement (P = .02).

Next Steps
This study suggests promise for a low-cost, largely satisfying SMS-distributed curriculum in terms of offering some benefit for short-term knowledge gain. Next steps include expanding such a curriculum to meet standard learning objectives for all fourth-year medical students entering residency.
The Relationship Between Chronic Pain, Depression, Psychosocial Factors, and Suicidality in Adolescents
Authors: Wildeboer Emily M. , Chambers Christine T. , Soltani Sabine , Noel Melanie 
Published: March 2023

Background:Chronic pain in youth is often associated with social conflict, depression, and suicidality. The interpersonal theory of suicide posits that there are psychosocial factors, such as peer victimization and lack of fear of pain, that may also influence suicidality.Objectives:The objective of this study was to determine whether depressive symptoms, peer victimization, and lack of fear of pain predict suicidality in adolescents with chronic pain. It was hypothesized that higher levels of depressive symptoms and peer victimization, and lower levels of fear of pain, would predict a higher lifetime prevalence of suicidality.Methods:Participants consisted of 184 youth with primary chronic pain conditions (10 to 18 y,M= 14.27 y). Measures included diagnostic clinical interviews assessing suicidality and self-report questionnaires assessing depressive symptoms, peer victimization, and fear of pain.Results:Forty-two (22.8%) participants reported suicidality. Regression analyses demonstrated that the occurrence of suicidality was associated with higher rates of depressive symptoms (β = 1.03,P= 0.020, 95% CI: 1.01, 1.06) and peer victimization (β = 2.23,P< 0.05, 95% CI: 1.07, 4.63), though there was no association between lower fear of pain and suicidality.Discussion:These results suggest that depressive symptoms and peer victimization are significant predictors of suicidality in adolescents with chronic pain; however, lower fear of pain was not shown to be a significant predictor. Given these findings, depression and peer victimization should be further explored and considered in the design and implementation of prevention and early intervention strategies that target chronic pain and suicidality in youth.