bluuebunny/crossref_metadata_2025_split huggingface dataset:
Targeting the pathogenesis and boosting the therapeutic efficacy of Parkinson's disease by advanced nanoparticles
Authors: Liu Hanghang , Hua Menglong , Zheng Qing , Gao Yifan , Li Zhen 
Published: June 2023

AbstractWith the aging of global population, the early diagnosis and treatment of neurodegenerative diseases such as Parkinson's disease (PD) have attracted considerable attention. Despite great advances achieved during the past decades, PD as the second largest neurodegenerative disease is still incurable. In the clinical practice, PD patients are mainly treated by drugs, and supplemented with deep brain stimulation or nerve nucleus destruction. The existing drugs can only relieve the symptoms of motor disorder, and cannot stop the progression of PD. Compared with small molecular drugs, nanoparticles exhibit multiple functions in the neuroprotection and neurorepair due to their tunable physical and chemical properties, easy modification and functionalization. Herein, we first briefly review the characteristics of nanoparticles crossing the blood–brain barrier, which is a primary challenge for the treatment of PD. Then, we summarize the pathologic mechanisms of PD and comprehensively discuss the novel PD therapy based on diverse nanoparticles, including alleviating oxidative stress, scavenging α‐synuclein aggregates, chelating metal ions, delivering neurotrophic factors and genes, and transplanting stem cells. This review aims to highlight the great potential of advanced nanoparticles in the therapy of PD.
Tracing green growth through industrial resource efficiency patterns: The role of competitiveness and clean technologies
Authors: Chatzistamoulou Nikos , Kounetas Kostas 
Published: June 2023

AbstractThe European Green Deal entails benefits for industrial transition to cleaner production through resource efficiency, paving the way to green transition. We develop a conceptual framework to study the drivers of resource efficiency of European industries towards green growth via segments of the countries' competitiveness under technological heterogeneity. Data on 13 industries in 17 European countries over an 8‐year period is used. Evidence shows that isolated efforts to improve productive performance harms environmental efficiency in low competitiveness countries. Results show that industrial environmental performance is affected by country's competitiveness, contributing to the implementation of the New Industrial Strategy of Europe.
Is Chemical Control for Crayfish in Hatchery Fish Shipments Practical?
Authors: Allert Ann L. , Westrich Daniel J. , Whites David W. , Knott Katrina K. , Storts Nathan , DiStefano Robert J. 
Published: June 2023

Abstract
Invasive crayfish (family Cambaridae) displace native crayfish species and alter aquatic habitat, community structure, and ecosystem function. We evaluated whether chemical control can be a reliable control agent for crayfish to ensure that shipments from fish hatcheries did not result in new infestations of invasive crayfish. A series of acute (≤1 h) toxicity tests were conducted to evaluate the toxicity of cypermethrin and pyrethrin to crayfish, freshwater mussels, and fish; chemical concentrations in test organisms; effectiveness of carbon-block filters to remove cypermethrin from test waters; and the cost of chemical control relative to extra handling of fish. Cypermethrin dosed at 75 μg/L for 15 min resulted in 100% mortality of adult white river crawfish Procambarus acutus and virile crayfish Faxonius virilis but did not cause &gt;20% mortality in adult pondmussel Ligumia subrostrata, juvenile fatmucket Lampsilis siliquoidea, fingerling Bluegill Lepomis macrochirus, hybrid sunfish (Bluegill × Green Sunfish L. cyanellus), hybrid Striped Bass (White Bass Morone chrysops × Striped Bass M. saxatilis), yearling Paddlefish Polyodon spathula, or ready-to-eat Bluegill, hybrid sunfish, and Channel Catfish Ictalurus punctatus. Behavioral effects, such as loss of equilibrium or head shaking, were generally limited to 1 h postexposure. Mean concentrations of cypermethrin increased in fish fillets (4–26 μg/g) and whole fish (5–1,770 μg/g); therefore, regulations limiting harvest for up to 7 d following stocking may be required. A carbon-block filtration system was effective in reducing (&lt;90%) cypermethrin concentrations and thus reducing potential effects to nontarget species in receiving waters. Extra handling of fish was more cost-effective for all fish tested except for Paddlefish, where the cost of chemical control was half that for extra handling. For all other fish tested, chemical control was 4–10 times more expensive than extra handling. Special use permits or chemical registration are needed before chemical control for crayfish could be routinely used at fish hatcheries.
Nurses' experience of integrating evidence‐based changes into their practice: A qualitative study
Authors: Khoddam Homeira , Modanloo Mahnaz , Mehrdad Neda , Heydari Fatemeh , Talebi Razieh 
Published: June 2023

AbstractAimTo explore the experiences of neonatal and NICU nurses on participating in evidence‐based changes in their neonatal pain management practice.DesignIt is a qualitative conventional content analysis.MethodsA purposive sample with nurses working in neonatal and NICUs was used. The data were collected through 11 semi‐structured in‐depth individual interviews, five focused group discussions, and observations and analyzed using the conventional content analysis method based on the Elo and Kyngäs model. The COREQ checklist was used for writing the report.ResultsAnalysis of gathered data led to the emergence of four themes, including ‘being in a supportive and encouraging atmosphere’, ‘a journey from resistance to adherence’, ‘achieving multi‐dimensional improvements’, and ‘facing obstructive challenges’.
An acid test for metformin†
Authors: Benjamin Don 
Published: June 2023

AbstractLactic acid export from highly glycolytic cancer cells is critical to maintain cellular homeostasis. The identification of syrosingopine as an inhibitor of the lactate transporters monocarboxylate transporter (MCT) 1 and the tumor‐induced isoform MCT4 suggests a potential therapeutic intervention. In a recent issue of this journal, Van der Vreken, Oudaert I and colleagues showed that syrosingopine, together with another drug metformin, had a synergistic effect in killing cultured multiple myeloma (MM) cell lines, primary MM blasts from patients, and in a mouse MM model. The antidiabetic drug metformin is currently also being investigated for anticancer efficacy. The synthetic lethality of these two drugs, which have good safety records and are approved for noncancer indications, raises the possibility of their combination for clinical anticancer therapy. © 2023 The Author. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland.
Prediction of the optimal vulcanization of a fiber‐reinforced elastomeric isolator made of natural rubber‐ethylene propylene diene monomer blend
Authors: Pianese G. , Milani G. , Milani F. 
Published: June 2023

AbstractTo seismically isolate a structure, it is possible to interpose a rubber device between the foundation and superstructure that increases the period of the superstructure, a feature that allows the structure to be “transparent” to the seismic excitation. A package of several rubber pads typically constitutes a seismic isolator; they are 10–20 mm thick vertically interspersed with either steel laminas or fiber‐reinforced polymer dry textiles suitably treated. So, the rubber has a primary role and must be vulcanized correctly to create the polymer cross‐linking properly. All rubber mechanical properties are strongly affected by curing temperature and curing time. Under vulcanization is a typical production error that suppliers make in large‐scale productions, especially when the size of the devices is considerable. It is common to deal with elastomeric isolators where rubber pads have been treated at a largely suboptimal temperature. This article proposes a numerical model for predicting the cross‐linking degree of rubber pads used in seismic isolation and made by a natural rubber‐ethylene propylene diene monomer rubber compound. The aim is to correctly define the optimal curing temperature and exposition time for producing a rubber quadruple shear test specimen and a fiber reinforced elastomeric isolator (FREI). The model is a kinetic one and takes into consideration the induction time. An experimental investigation has been conducted to validate the model with visible inspections and hardness measurements taken on the rubber pads (quadruple shear specimens) and the rubber devices. The results have shown the reliability of the new numerical model proposed, with a homogeneous mechanical properties distribution obtained within the rubber pads and the FREI.
Investigating the exchange of plant material between European and African botanical institutions for research and development
Authors: Ashenafi Ayenew , Smith Paul , Kiehn Michael , Woldeyes Feleke , Demissew Sebsebe 
Published: June 2023

Social Impact StatementThe exchange of plant material and data is essential for supporting collaborative research efforts to address global challenges. In order to promote collaboration between Plant Genetic Resource (PGR) organizations in conservation research and development and to improve the sustainable utilization of PGRs, constraints to plant material and data exchange must be addressed. This can only be achieved through the introduction of policy measures that will build trust among institutions and encourage facilitated plant material exchange, equitable benefit sharing, and compliance with Access and Benefit Sharing (ABS) instruments. The resulting improvements in the conservation and sustainable utilization of PGRs will improve food security, public health, livelihoods, sustainable development, and ecological sustainability.Summary

The aim of this study was to assess the extent of plant material exchange between European and African Plant Genetic Resource (PGR) organizations for research and development.
Data were collected from Index Seminum databases and through a survey questionnaire. They were statistically analyzed using a chi‐square test and Spearman correlation coefficient using SPSS, version 25.
The study indicated that the extent of plant material exchange between African and European PGR organizations for research and development is insignificant compared with the exchange between European institutions. Plant material exchange usually included benefit sharing, and the most commonly shared benefits were knowledge transfer, participation in research, access to research results, and joint authorship of publications. Many of the respondents were not very familiar with Access and Benefit Sharing (ABS) principles and regulations. The major constraints to plant material exchange were found to be cumbersome bureaucratic procedures, poor knowledge of compliance requirements, lack of national ABS regulations, poor quality of data associated with collections, and lack of tracking mechanisms.
The low level of plant material exchange between African and European institutions is also most probably due to limited human and technological capacity in African institutions that restrict their involvement in research and development. Therefore, there is a need to build trust and to increase human and technological capacities for research in African institutions to strengthen collaboration by ensuring facilitated exchange and equitable benefit sharing.
Anterior component of Y‐Balance test is correlated to ankle dorsiflexion range of motion in futsal players: A cross‐sectional study
Authors: Rafagnin Camilo Zumbi , Ferreira Arthur de Sá , Telles Gustavo Felicio , Lemos de Carvalho Thiago , Alexandre Dângelo José de Andrade , Nogueira Leandro Alberto Calazans 
Published: June 2023

AbstractBackground and purposeRestricted dorsiflexion range of motion (DFROM) could impact dynamic balance in sports. This study aimed to investigate the relationship between dorsiflexion range of motion and the Y‐Balance Test (YBT) in elite futsal players.MethodsSixty‐one asymptomatic male futsal players (mean age 26.57 (5.64) years, a mean body mass index of 25.40 (2.69) kg/m2) were included. DFROM was measured by the weight‐bearing lunge test (WBLT). DFROM data were obtained using smartphone‐based motion capture. The Pearson correlation coefficient verified the correlation between the variables.ResultsDominant and nondominant leg ankle DFROM was significantly correlated with the anterior component of YBT (r = 0.27 and 0.51, respectively). The posteromedial component and the composite score of the YBT were also significantly correlated with nondominant leg ankle DFROM (r = 0.31 and 0.34, respectively)]. The other measures were not statistically significant. DFROM explained between 7% and 24% of the variation of the distances reached in the YBT.ConclusionDorsiflexion range of motion measured by weight bearing lunge test is positively correlated with dynamic balance in futsal players.
Effect of temperature and nucleotide on the binding of BiP chaperone to a protein substrate
Authors: Rivera Maira , Burgos‐Bravo Francesca , Engelberger Felipe , Asor Roi , Lagos‐Espinoza Miguel I. A. , Figueroa Maximiliano , Kukura Philipp , Ramírez‐Sarmiento César A. , Baez Mauricio , Smith Steven B. , Wilson Christian A. M. 
Published: June 2023

AbstractBiP (immunoglobulin heavy‐chain binding protein) is a Hsp70 monomeric ATPase motor that plays broad and crucial roles in maintaining proteostasis inside the cell. Structurally, BiP is formed by two domains, a nucleotide‐binding domain (NBD) with ATPase activity connected by a flexible hydrophobic linker to the substrate‐binding domain. While the ATPase and substrate binding activities of BiP are allosterically coupled, the latter is also dependent on nucleotide binding. Recent structural studies have provided new insights into BiP's allostery; however, the influence of temperature on the coupling between substrate and nucleotide binding to BiP remains unexplored. Here, we study BiP's binding to its substrate at the single molecule level using thermo‐regulated optical tweezers which allows us to mechanically unfold the client protein and explore the effect of temperature and different nucleotides on BiP binding. Our results confirm that the affinity of BiP for its protein substrate relies on nucleotide binding, by mainly regulating the binding kinetics between BiP and its substrate. Interestingly, our findings also showed that the apparent affinity of BiP for its protein substrate in the presence of nucleotides remains invariable over a wide range of temperatures, suggesting that BiP may interact with its client proteins with similar affinities even when the temperature is not optimal. Thus, BiP could play a role as a “thermal buffer” in proteostasis.
Influence of the number of hosts and the risk of predation on the foraging behavior of the parasitoid Eretmocerus eremicus
Authors: Chavarín‐Gómez Luis Enrique , Torres‐Enciso Pedro , Palmeros‐Suárez Paola Andrea , Ramirez‐Romero Ricardo 
Published: June 2023

AbstractBackgroundParasitoids are natural enemies that can modify their behaviors as they search for hosts based on the characteristics of the sites in which they forage. Theoretical models predict that a parasitoid will stay for longer periods in high‐quality sites or patches than in those of low quality. In turn, patch quality may be linked to factors such as the number of hosts and the risk of predation. In the present study, we sought to determine if the factors of the number of hosts, risk of predation, and their interaction influence the foraging behavior of the parasitoid Eretmocerus eremicus (Hymenoptera: Aphelinidae) as theory predicts. To do this, we evaluated different parameters of parasitoid foraging behavior, such as residence time, number of oviposition events, and attacks, in sites of different patch quality.ResultsOur results show that when the factors, number of hosts, and, risk of predation, were evaluated separately, E. eremicus resided for longer periods and oviposited more frequently in patches with a high number of hosts and low risk of predation than in other patches. However, when both of these factors were combined, only the number of hosts influenced some aspects of the foraging behavior of this parasitoid, such as the number of oviposition events and attacks.ConclusionFor some parasitoids like E. eremicus, theoretical predictions may be fulfilled when patch quality is linked to the number of hosts but will not be fully satisfied when patch quality is related to the risk of predation. Furthermore, at sites with different combinations of host numbers and risk of predation, host number appears to be more critical than predation risk. These results suggest that the performance of the parasitoid E. eremicus to control whiteflies will be mainly mediated by the levels of whitefly infestation and, to a small extent, by the risk of predation to which the parasitoid is subjected. © 2023 Society of Chemical Industry.
Clinical features do not identify risk of progression from isolated postcapillary pulmonary hypertension to combined pre‐ and postcapillary pulmonary hypertension
Authors: Babu Gautam , Annis Jeffrey S. , Garry Jonah D. , Freiberg Matthew S. , Hemnes Anna R. , Brittain Evan L. 
Published: June 2023

AbstractPulmonary hypertension is a common sequelae of left heart failure and may present as isolated postcapillary pulmonary hypertension (Ipc‐PH) or combined pre‐ and postcapillary pulmonary hypertension (Cpc‐PH). Clinical features associated with progression from Ipc‐PH to Cpc‐PH have not yet been described. We extracted clinical data from patients who underwent right heart catheterizations (RHC) on two separate occasions. Ipc‐PH was defined as mean pulmonary pressure >20 mmHg, pulmonary capillary wedge pressure >15 mmHg, and pulmonary vascular resistance (PVR) < 3 WU. Progression to Cpc‐PH required an increase in PVR to ≥3 WU. We performed a retrospective cohort study with repeated assessments comparing subjects that progressed to Cpc‐PH to subjects that remained with Ipc‐PH. Of 153 patients with Ipc‐PH at baseline who underwent a repeat RHC after a median of 0.7 years (IQR 0.2, 2.1), 33% (50/153) had developed Cpc‐PH. In univariate analysis comparing the two groups at baseline, body mass index (BMI) and right atrial pressure were lower, while the prevalence of moderate or worse mitral regurgitation (MR) was higher among those who progressed. In age‐ and sex‐adjusted multivariable analysis, only BMI (OR 0.94, 95% CI 0.90–0.99, p = 0.017, C = 0.655) and moderate or worse MR (OR 3.00, 95% CI 1.37–6.60, p = 0.006, C = 0.654) predicted progression, but with poor discriminatory power. This study suggests that clinical features alone cannot distinguish patients at risk for development of Cpc‐PH and support the need for molecular and genetic studies to identify biomarkers of progression.
Endometrial thickness after dilation and evacuation: A retrospective cohort study
Authors: Mastey Namrata , Baker Courtney C. , Uhm Suji , Chen Melissa J. , Matulich Melissa C. , Melo Juliana , Hou Melody Y. , Creinin Mitchell D. 
Published: June 2023

AbstractObjectiveTo evaluate endometrial thickness 1–2 h after dilation and evacuation (D&E).MethodsWe used a deidentified single‐institution database to retrospectively evaluate endometrial thickness measurements obtained as part of routine care 1–2 h postprocedure using transabdominal ultrasonography from 17 March 2020 to 16 October 2020. From this database, we extracted measurements, procedural outcomes and postoperative bleeding interventions. We assessed our primary outcome of endometrial thickness and the relationship between endometrial thickness and the need for bleeding‐related interventions within 4 h postprocedure.ResultsWe performed 213 endometrial thickness evaluations at a mean gestational age of 19.2 ± 2.8 weeks with median quantitative intraoperative blood loss of 150 mL (10–2000 mL). We found a median endometrial thickness of 12.2 mm (interquartile range [IQR]: 9.1–16 mm) performed 89.6 ± 19.3 min after the D&E. Eleven (5.2%) patients needed further interventions for bleeding during recovery, with all but one having bleeding issues before or at the same time as the ultrasound examination. Patients with and without bleeding issues had median endometrial thicknesses of 20.3 mm (IQR: 12.5–29.2 mm, range: 1.2–42 mm) and 12.2 mm (IQR: 9.0–15.8 mm, range: 2.1–43 mm), respectively, p = 0.008.ConclusionEndometrial thickness 1–2 h after D&E can vary widely but 75% of patients have a measurement <16 mm. Although patients with bleeding complications have slightly thicker endometrial linings, these patients typically present clinically and endometrial assessment does not predict the need for intervention.
Sulfide Oxidation on Ladder‐Type Heteroarenes to Construct All‐Acceptor Copolymers for Visible‐Light‐Driven Hydrogen Evolution
Authors: Lin Wei‐Cheng , Chang Chih‐Li , Shih Chin‐Hsuan , Lin Wan‐Chi , Yu Lai Ze‐ , Chang Je‐Wei , Ting Li‐Yu , Huang Tse‐Fu , Sun Yu‐En , Huang Hung‐Yi , Lin Yu‐Tung , Liu Jia‐Jen , Wu Yi‐Hsiang , Tseng Yuan‐Ting , Zhuang Ying‐Rang , Li Bing‐Heng , Su An‐Chung , Yu Chi‐Hua , Chen Chin‐Wen , Lin Kun‐Han , Jeng U‐Ser , Chou Ho‐Hsiu 
Published: June 2023

AbstractConjugated polymers (CPs) have recently gained increasing attention as photocatalysts for sunlight‐driven hydrogen evolution. However, they suffer from insufficient electron output sites and poor solubility in organic solvents, severely limiting their photocatalytic performance and applicability. Herein, solution‐processable all–acceptor (A1–A2)‐type CPs based on sulfide‐oxidized ladder‐type heteroarene are synthesized. A1–A2‐type CPs showed upsurging efficiency improvements by two to three orders of magnitude, compared to their donor–acceptor ‐type CP counterparts. Furthermore, by seawater splitting, PBDTTTSOS exhibited an apparent quantum yield of 18.9% to 14.8% at 500 to 550 nm. More importantly, PBDTTTSOS achieved an excellent hydrogen evolution rate of 35.7 mmol h−1 g−1 and 150.7 mmol h−1 m−2 in the thin‐film state, which is among the highest efficiencies in thin film polymer photocatalysts to date. This work provides a novel strategy for designing polymer photocatalysts with high efficiency and broad applicability.
Synthesis, Characterization, and Investigation of Coating Properties of Carboxymethyl Acorn Starch (CMAS)
Authors: Celikci Nuran , Shaikiyeva Nurzat , Moldobaev Mirlan , Kemelov Kubat , Iskakova Janyl , Dolaz Mustafa 
Published: June 2023

AbstractKyrgyzstan is a landlocked country in Central Asia, famous for its crystal‐clear lakes, majestic Tien Shan Mountains that bisect the territory of Turkistan, and magnificent natural beauty. This study aims to evaluate the fruit (acorns) of the oak trees (Quercus roburL.) grown in Bishkek, the capital city of Kyrgyzstan. For this purpose, carboxymethyl acorn starch (CMAS), which is not synthesized in literature, is first synthesized by isolating acorn starch (AS) from the acorns. The structures of CMASs are characterized by1H(13C)‐NMR, FT‐IR, XRD, and SEM techniques. The viscosities of the samples with different degrees of substitution (DS), such as 0.62, 0.95, and 1.01, determined by the titrimetric method, are measured as 247, 600, and 388 mPa s, respectively. In addition, considering the film‐forming properties of CMASs, tomatoes are coated, and their shelf lives are investigated. Weight loss (WL) is 38.36% in control and 25.52% in coated tomato after 4 weeks. The needle penetration depth is measured as 388 mm in the control and 249 mm in the coated tomato. Total soluble solids (TSS) content showed approximate results in both samples. Control tomatoes containing 78.8 mg 100 g−1ascorbic acid lost significantly during storage, reducing to 13.90 mg 100 g−1.