bluuebunny/crossref_metadata_2025_split huggingface dataset:
Maize heat shock proteins—prospection, validation, categorization and in silico analysis of the different ZmHSP families
Authors: Diogo- Rubens , de Resende Von Pinho Edila Vilela , Pinto Renan Terassi , Zhang Lingrui , Condori-Apfata Jorge Alberto , Pereira Paula Andrade , Vilela Danielle Rezende 
Published: September 2023

AbstractAmong the plant molecular mechanisms capable of effectively mitigating the effects of adverse weather conditions, the heat shock proteins (HSPs), a group of chaperones with multiple functions, stand out. At a time of full progress on the omic sciences, they look very promising in the genetic engineering field, especially in order to conceive superior genotypes, potentially tolerant to abiotic stresses (AbSts). Recently, some works concerning certain families of maize HSPs (ZmHSPs) were published. However, there was still a lack of a study that, with a high degree of criteria, would fully conglomerate them. Using distinct but complementary strategies, we have prospected as many ZmHSPs candidates as possible, gathering more than a thousand accessions. After detailed data mining, we accounted for 182 validated ones, belonging to seven families, which were subcategorized into classes with potential for functional parity. In them, we identified dozens of motifs with some degree of similarity with proteins from different kingdoms, which may help explain some of their still poorly understood means of action. Through in silico and in vitro approaches, we compared their expression levels after controlled exposure to several AbSts' sources, applied at diverse tissues, on varied phenological stages. Based on gene ontology concepts, we still analyzed them from different perspectives of term enrichment. We have also searched, in model plants and close species, for potentially orthologous genes. With all these new insights, which culminated in a plentiful supplementary material, rich in tables, we aim to constitute a fertile consultation source for those maize researchers attracted by these interesting stress proteins.
Confederal Union and Empire: Placing the Albany Plan (1754) in Imperial Context
Authors: Pincus Steve 
Published: September 2023

AbstractWhy did British politicians on both sides of the Atlantic propose a confederal rather than incorporating union in 1754? This question has been difficult to answer because most scholars have focused on the Albany Plan of Union outside of its imperial context, seeing in the plan either evidence of nascent American nationalism, a point of divergence between American and British conceptions of empire, or a missed moment to establish parliamentary supremacy over America. I show instead that the British and American plans for confederal union in 1754 formed part of an intensely partisan and pan-imperial debate about the nature of the British imperial constitution. The failure to adopt a confederal imperial constitution in 1754 had more to do with the contingency of the outbreak of the Seven Years’ War than with diverging British and American visions of empire or nascent American nationalism.
Revisiting “Racial Capitalism”
Authors: Subrahmanyam Sanjay 
Published: September 2023

AbstractThe brief essay is a response to an article by the French sociologist Loïc Wacquant which critiques the concept of “racial capitalism” that has gained much prominence and currency in recent times. It offers a historical analysis of the emergence of “race” as a concept in the Euro-Atlantic sphere and points to the complexities in extending it beyond that space, into the Indian Ocean world for example. As a consequence, the ambitious claims made by some theorists of “racial capitalism” appear difficult to sustain.
The effects of conjugated linoleic acid supplementation on anthropometrics and body composition indices in adults: a systematic review and dose–response meta-analysis
Authors: Asbaghi Omid , Shimi Ghazaleh , Hosseini Oskouie Fatemeh , Naseri Kaveh , Bagheri Reza , Ashtary-Larky Damoon , Nordvall Michael , Rastgoo Samira , Zamani Mohammad , Wong Alexei 
Published: September 2023

AbstractPrior meta-analytic investigations over a decade ago rather inconclusively indicated that conjugated linoleic acid (CLA) supplementation could improve anthropometric and body composition indices in the general adult population. More recent investigations have emerged, and an up-to-date systematic review and meta-analysis on this topic must be improved. Therefore, this investigation provides a comprehensive systematic review and meta-analysis of randomised controlled trials (RCT) on the impact of CLA supplementation on anthropometric and body composition (body mass (BM), BMI, waist circumference (WC), fat mass (FM), body fat percentage (BFP) and fat-free mass (FFM)) markers in adults. Online databases search, including PubMed, Scopus, the Cochrane Library and Web of Science up to March 2022, were utilised to retrieve RCT examining the effect of CLA supplementation on anthropometric and body composition markers in adults. Meta-analysis was carried out using a random-effects model. The I2 index was used as an index of statistical heterogeneity of RCT. Among the initial 8351 studies identified from electronic databases search, seventy RCT with ninety-six effect sizes involving 4159 participants were included for data analyses. The results of random-effects modelling demonstrated that CLA supplementation significantly reduced BM (weighted mean difference (WMD): −0·35, 95 % CI (−0·54, −0·15), P < 0·001), BMI (WMD: −0·15, 95 % CI (−0·24, −0·06), P = 0·001), WC (WMD: −0·62, 95% CI (−1·04, −0·20), P = 0·004), FM (WMD: −0·44, 95 % CI (−0·66, −0·23), P < 0·001), BFP (WMD: −0·77 %, 95 % CI (−1·09, −0·45), P < 0·001) and increased FFM (WMD: 0·27, 95 % CI (0·09, 0·45), P = 0·003). The high-quality subgroup showed that CLA supplementation fails to change FM and BFP. However, according to high-quality studies, CLA intake resulted in small but significant increases in FFM and decreases in BM and BMI. This meta-analysis study suggests that CLA supplementation may result in a small but significant improvement in anthropometric and body composition markers in an adult population. However, data from high-quality studies failed to show CLA’s body fat-lowering properties. Moreover, it should be noted that the weight-loss properties of CLA were small and may not reach clinical importance.
The Reidemeister spectrum of finite abelian groups
Authors: Senden Pieter 
Published: September 2023

AbstractFor a finite abelian group A, the Reidemeister number of an endomorphism φ is the same as the number of fixed points of φ, and the Reidemeister spectrum of A is completely determined by the Reidemeister spectra of its Sylow p-subgroups. To compute the Reidemeister spectrum of a finite abelian p-group P, we introduce a new number associated to an automorphism ψ of P that captures the number of fixed points of ψ and its (additive) multiples, we provide upper and lower bounds for that number, and we prove that every power of p between those bounds occurs as such a number.
Reassessing the Marginalization of Astrology in the Early Modern World
Authors: Pfeffer Michelle 
Published: September 2023

AbstractThe marginalization of astrology – the protracted process by which a rich scholarly field and a highly skilled trade migrated into the margins of European culture – is coming to be recognized as one of the most fundamental transformations in the transition from the pre-modern to the modern world. Long assumed to be a casualty of the ‘scientific revolution’ and ‘Enlightenment’, since the 1970s historians have questioned the power of intellectual developments to carry the weight of this major shift, and have constructed alternative social, political, and cultural narratives. However, in the last fifteen years, the field has been making a (re-)turn to intellectual history, albeit in innovative ways. This critical historiographical review accumulates and digests this large body of new work, showing how these historiographical about-turns leave us with broader questions about the role of ideas in cultural transformations, as well as – on a smaller scale – the processes by which individuals change their minds. I close the review by contending that after decades of neglect, it is an opportune time to bring intellectual history back into our studies of the ‘disenchantment of the world’.
A Scato-sexual Message: The Secundinus Stone with Phallus from Vindolanda
Authors: Meyer Alexander , Mullen Alex , Vanhala Joonas 
Published: September 2023

AbstractThe Secundinus stone, with its combination of carved phallus and text, was found in 2022 in excavations within the stone fort at Vindolanda. We consider comparanda for the imagery from Vindolanda, Britannia and further afield, and textual parallels particularly from Pompeii. We offer several possible interpretations of the object and prefer an analysis which takes the text, SECVNDINVS CACOR, as it is carved. This interpretation would add an otherwise unattested verbal form to the Latin scato-sexual vocabulary.
Agriculture and Population: Occupation and Burials in the Extramural Area of Margidunum on the Fosse Way in Nottinghamshire
Authors: Simmonds Andrew , Allen Martyn , McIntyre Lauren , Champness Carl 
Published: September 2023

AbstractThis paper presents the results of an excavation that uncovered c. 390 m of roadside plots within the ribbon development alongside the Fosse Way on the south-west periphery of the walled small town of Margidunum in Nottinghamshire. The roadside plots appear to have been used for a combination of domestic occupation and agricultural activity, and to the rear lay 54 inhumation burials in 52 graves (including two double burials) and a single urned cremation burial, whose skeletons bore evidence for the tough working lives of the individuals. These are interpreted as the remains of peasant farmers and as evidence for the agricultural focus of the settlement, and of ‘small towns’ more generally. A contrast is drawn between the apparent poverty of this community and the apparently more high-status occupation within the defended core of the town.
Dirichlet law for factorisation of integers, polynomials and permutations
Authors: LEUNG SUN–KAI 
Published: September 2023

AbstractLet
$k \geqslant 2$
be an integer. We prove that factorisation of integers into k parts follows the Dirichlet distribution
$\mathrm{Dir}\left({1}/{k},\ldots,{1}/{k}\right)$
by multidimensional contour integration, thereby generalising the Deshouillers–Dress–Tenenbaum (DDT) arcsine law on divisors where
$k=2$
. The same holds for factorisation of polynomials or permutations. Dirichlet distribution with arbitrary parameters can be modelled similarly.
COVID-19 Direct Relief Payments and Political and Economic Attitudes among Tertiary Students: A Quasi-Experimental Study
Authors: Wong Mathew Y. H. , Kwong Ying-Ho 
Published: September 2023

ABSTRACTDuring the COVID-19 pandemic, ad hoc direct relief payments were used extensively as a means of economic stimulation and individual compensation. Current studies are focusing on the economic impact of these policies, but they seldom consider how these payments affect individual beliefs and attitudes. This study used a survey with quasi-experimental elements to examine how these payments affected tertiary students in Hong Kong by focusing primarily on a cohort including both eligible and noneligible students. Whereas satisfaction with the economy and government and support for democracy were not affected, nonrecipients assigned greater importance to meritocratic factors in improving life outcomes. The findings of this study shed light on how governments inadvertently may be affecting the outlook of young adults with transfers during the COVID-19 pandemic.
Integrating Logic Rules with Everything Else, Seamlessly
Authors: LIU YANHONG A. , STOLLER SCOTT D. , TONG YI , LIN BO 
Published: September 2023

AbstractThis paper presents a language, Alda, that supports all of logic rules, sets, functions, updates, and objects as seamlessly integrated built-ins. The key idea is to support predicates in rules as set-valued variables that can be used and updated in any scope, and support queries using rules as either explicit or implicit automatic calls to an inference function. We have defined a formal semantics of the language, implemented a prototype compiler that builds on an object-oriented language that supports concurrent and distributed programming and on an efficient logic rule system, and successfully used the language and implementation on benchmarks and problems from a wide variety of application domains. We describe the compilation method and results of experimental evaluation.
International environmental law as a means for enhancing the protection of the environment in warfare: A critical assessment of scholarly theoretical frameworks
Authors: van Steenberghe Raphaël 
Published: September 2023

AbstractThe protection of the environment during warfare attracted significant attention in the 1990s, especially after the 1990–91 Gulf War. It became clear at that time that the few rules provided by international humanitarian law (IHL) aimed specifically at protecting the environment were insufficient. Various studies have since been undertaken with the aim of strengthening that protection from an IHL perspective. It is only recently that scholars and institutions like the International Law Commission have started to reflect on how to better protect the environment in armed conflict through the lens of another branch of international law, namely, international environmental law (IEL). Such an approach has involved examining the interplay between IHL and IEL, and scholars have subsequently proposed and then elaborated on frameworks in that respect. This paper intends to identify common trends of those frameworks and to critically appraise them, with the aim of providing a suitable approach to the interplay between IHL and IEL.
Synergies Between NASA's Hyperspectral Aquatic Missions PACE, GLIMR, and SBG: Opportunities for New Science and Applications
Authors: Dierssen H. M. , Gierach M. , Guild L. S. , Mannino A. , Salisbury J. , Schollaert Uz S. , Scott J. , Townsend P. A. , Turpie K. , Tzortziou M. , Urquhart E. , Vandermeulen R. , Werdell P. J. 
Published: September 2023

AbstractWithin the next decade, NASA plans to launch three new missions with imaging spectrometers for aquatic science and applications: Plankton, Aerosol, Cloud, ocean Ecosystem (PACE) in 2024, Geostationary Littoral Imaging Radiometer (GLIMR) in 2026, and Surface Biology and Geology (SBG) in 2028. Taken together, these missions will evaluate long‐term trends in phytoplankton biomass linked to climate change, and provide new spectral capabilities to assess aquatic biogeochemistry, biophysics, and habitats. Hyperspectral measurements of ocean color, paired with advanced retrieval algorithms, can provide new information on phytoplankton community composition and water quality. We compare the mission architecture and sensor characteristics to identify the synergistic opportunities to merge algorithms, field data, and calibration and validation techniques. Each mission has unique temporal and spatial characteristics to monitor the aquatic transitions from watershed to open ocean ecosystems. SBG provides observations at high spatial scales to monitor emergent, floating, submerged, and benthic habitats from inland to coastal waters. With global daily coverage, PACE can track the fate of material as it meanders offshore and provides an enhanced context for phytoplankton diversity and global biogeochemical cycling. GLIMR is optimized to resolve temporal processes that give rise to aquatic rates and fluxes including phytoplankton growth rates, physiology, and episodic events such as storms. Applications with high spectral, spatial, and temporal resolution from these NASA missions include assessing carbon dynamics and biogeochemical cycling across the land‐ocean continuum, harmful algal blooms, and oil spills.
Effects of probiotics in patients with morbid obesity undergoing bariatric surgery: a systematic review and meta-analysis
Authors: Wang Yuting , Zheng Youwei , Kuang Lirun , Yang Keyu , Xie Jiaji , Liu Xinde , Shen Shan , Li Xinchao , Wu Shiran , Yang Yuyi , Shi Jiafei , Wu Jialiang , Wang Yong 
Published: September 2023

Abstract
Background
Probiotics are commonly used after bariatric surgery. However, uncertainty remains regarding their effects. The purpose of this systematic review was to assess the effect of probiotics in patients with morbid obesity undergoing bariatric surgery.

Methods
PubMed, Cochrane Library, Embase, Science Direct, and Web of Science were searched from inception to April 4, 2023. No language restrictions were applied. Relevant randomized controlled trials and controlled clinical trials were included. We used the aggregated data extracted from the trials and assessed the heterogeneity. When severe heterogeneity was detected, a random effect model was used. All stages of the review were done by independent authors.

Results
We screened 2024 references and included 11 randomized controlled trials and controlled clinical trials. Compared with the protocol groups, probiotics showed significant effects on regulating aspartate amino transferase level (MD = −4.32 U/L; 95% CI [−7.10, −1.53], p = 0.002), triglycerides (MD = −20.16 mg/dL; 95% CI [−34.51, −5.82], p = 0.006), weight (MD = −1.99 kg; 95% CI [−3.97, −0.01], p = 0.05), vitamin B12 (MD = 2.24 pg/dL; 95% CI [−0.02, 4.51], p = 0.05), dietary energy (MD = −151.03 kcal; 95% CI [−215.68, −86.37], p < 0.00001), dietary protein (MD = −4.48 g/day, 95% CI [−8.76, −0.20], p = 0.04), dietary carbohydrate (MD = −34.25 g/day, 95% CI [−44.87, −23.62], p < 0.00001), and dietary fiber (MD = −2.17 g/day, 95% CI [−3.21, −1.14], p < 0.0001). There were no severe side effects related to probiotics.

Conclusions
Our meta-analysis suggested that probiotics may delay the progression of liver function injury, improve lipid metabolism, reduce weight, and reduce food intake, although the effects on other indicators were insignificant. Probiotics may be helpful for patients undergoing bariatric surgery. The review was registered on PROSPERO (International prospective register of systematic reviews): CRD42023407970. No primary source of funding.
Host and microbiome jointly contribute to environmental adaptation
Authors: Petersen Carola , Hamerich Inga K , Adair Karen L , Griem-Krey Hanne , Torres Oliva Montserrat , Hoeppner Marc P , Bohannan Brendan J M , Schulenburg Hinrich 
Published: September 2023

Abstract
Most animals and plants have associated microorganisms, collectively referred to as their microbiomes, which can provide essential functions. Given their importance, host-associated microbiomes have the potential to contribute substantially to adaptation of the host-microbiome assemblage (the “metaorganism”). Microbiomes may be especially important for rapid adaptation to novel environments because microbiomes can change more rapidly than host genomes. However, it is not well understood how hosts and microbiomes jointly contribute to metaorganism adaptation. We developed a model system with which to disentangle the contributions of hosts and microbiomes to metaorganism adaptation. We established replicate mesocosms containing the nematode Caenorhabditis elegans co-cultured with microorganisms in a novel complex environment (laboratory compost). After approximately 30 nematode generations (100 days), we harvested worm populations and associated microbiomes, and subjected them to a common garden experiment designed to unravel the impacts of microbiome composition and host genetics on metaorganism adaptation. We observed that adaptation took different trajectories in different mesocosm lines, with some increasing in fitness and others decreasing, and that interactions between host and microbiome played an important role in these contrasting evolutionary paths. We chose two exemplary mesocosms (one with a fitness increase and one with a decrease) for detailed study. For each example, we identified specific changes in both microbiome composition (for both bacteria and fungi) and nematode gene expression associated with each change in fitness. Our study provides experimental evidence that adaptation to a novel environment can be jointly influenced by host and microbiome.
Novel SPEG variants in a neonate with severe dilated cardiomyopathy and relatively mild hypotonia
Authors: Fujimoto Hana Milena , Fujimoto Masanori , Sugiura Takahiro , Nakane Shigeharu , Wakano Yasuhiro , Sato Emi , Oshita Hironori , Togawa Yasuko , Sugimoto Mari , Kato Takenori , Yasuda Kazushi , Muramatsu Kanji , Saitoh Shinji 
Published: September 2023

AbstractStriated muscle preferentially expressed protein kinase (SPEG) variants have been reported to cause centronuclear myopathy associated with cardiac diseases. The severity of skeletal muscle symptoms and cardiac symptoms are presumably related to the location of the variant. Here, we report novel SPEG compound heterozygous pathological variants in a neonate with severe dilated cardiomyopathy and relatively mild hypotonia. This report expands the genotype-phenotype correlations of patients with SPEG variants.
NAD(H) homeostasis underlies host protection mediated by glycolytic myeloid cells in tuberculosis
Authors: Pacl Hayden T. , Chinta Krishna C. , Reddy Vineel P. , Nadeem Sajid , Sevalkar Ritesh R. , Nargan Kievershen , Lumamba Kapongo , Naidoo Threnesan , Glasgow Joel N. , Agarwal Anupam , Steyn Adrie J. C. 
Published: September 2023

AbstractMycobacterium tuberculosis (Mtb) disrupts glycolytic flux in infected myeloid cells through an unclear mechanism. Flux through the glycolytic pathway in myeloid cells is inextricably linked to the availability of NAD+, which is maintained by NAD+ salvage and lactate metabolism. Using lung tissue from tuberculosis (TB) patients and myeloid deficient LDHA (LdhaLysM−/−) mice, we demonstrate that glycolysis in myeloid cells is essential for protective immunity in TB. Glycolytic myeloid cells are essential for the early recruitment of multiple classes of immune cells and IFNγ-mediated protection. We identify NAD+ depletion as central to the glycolytic inhibition caused by Mtb. Lastly, we show that the NAD+ precursor nicotinamide exerts a host-dependent, antimycobacterial effect, and that nicotinamide prophylaxis and treatment reduce Mtb lung burden in mice. These findings provide insight into how Mtb alters host metabolism through perturbation of NAD(H) homeostasis and reprogramming of glycolysis, highlighting this pathway as a potential therapeutic target.
The mutational landscape of the adult healthy parous and nulliparous human breast
Authors: Cereser Biancastella , Yiu Angela , Tabassum Neha , Del Bel Belluz Lisa , Zagorac Sladjana , Ancheta Kenneth Russell Zapanta , Zhong Rongrong , Miere Cristian , Jeffries-Jones Alicia Rose , Moderau Nina , Werner Benjamin , Stebbing Justin 
Published: September 2023

AbstractThe accumulation of somatic mutations in healthy human tissues has been extensively characterized, but the mutational landscape of the healthy breast is still poorly understood. Our analysis of whole-genome sequencing shows that in line with other healthy organs, the healthy breast during the reproduction years accumulates mutations with age, with the rate of accumulation in the epithelium of 15.24 ± 5 mutations/year. Both epithelial and stromal compartments contain mutations in breast-specific driver genes, indicative of subsequent positive selection. Parity- and age-associated differences are evident in the mammary epithelium, partly explaining the observed difference in breast cancer risk amongst women of different childbearing age. Parity is associated with an age-dependent increase in the clone size of mutated epithelial cells, suggesting that older first-time mothers have a higher probability of accumulating oncogenic events in the epithelium compared to younger mothers or nulliparous women. In conclusion, we describe the reference genome of the healthy female human breast during reproductive years and provide evidence of how parity affects the genomic landscape of the mammary gland.