bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring phosphoryl oxygen basicity in U(VI) complexation: A comparative study from trialkyl phosphate to phosphine oxide
Authors: Sachin Aditya Ramesh , Gopakumar Gopinadhanpillai , Rao Cherukuri Venkata Siva Brahmananda , Nagarajan Sivaraman 
Published: September 2023

AbstractThe conventional argument that extraction efficiency depends on the “basicity of the phosphoryl oxygen” is thoroughly examined in this study. The analysis involves studying the electronic structures of various ligands, such as phosphate, phosphonate, phosphinate, and phosphine oxide, as well as variations in their alkyl chain length, and their corresponding uranium complexes. The studies revealed a significant amount of destabilizing strain and steric repulsion for ligands having longer alkyl chains upon complexation. A considerable amount of stabilizing orbital and dispersion interactions compensate for these repulsions, forming stable complexes. Dispersion interactions become more significant upon chain elongation and are mainly responsible for the preference for U(VI) metal ions by ligands with lengthy alkyl chain units. The preference of phosphine oxide ligands for U(VI) is analyzed within the context of enhanced orbital interactions resulting from the energetically close donor (ligand) and acceptor (metal nitrate) orbitals. Additionally, dispersion‐based interactions also become significant, especially with larger chain lengths. The electronegative environment around the phosphorus atom, along with the existence of low‐dipole moment structures, is also examined in relation to their possible role in solvent extraction and their influence on the selectivity of ligands for uranyl species.
Downregulation of AP1S1 causes the lysosomal degradation of EGFR in non‐small cell lung cancer
Authors: Jeong Jangho , Hwang Ye Eun , Lee Minwoo , Keum Seula , Song Seongeun , Kim Jung‐Woong , Choi Jee‐Hye , Rhee Sangmyung 
Published: September 2023

AbstractMatrix stiffness has been shown to play a critical role in cancer progression by influencing various cellular processes, including epidermal growth factor (EGF) signaling. However, the underlying molecular mechanisms are not fully understood. Here, we investigated the role of adaptor‐related protein complex 1 subunit sigma 1 (AP1S1), a component of adaptor protein complex‐1, in the regulation of EGF receptor (EGFR) intracellular trafficking during cancer cell progression. We found that AP1S1 expression was upregulated under stiff matrix conditions, resulting in the regulation of EGFR trafficking in non‐small cell lung adenocarcinoma cells. Knockout of AP1S1 caused the lysosomal degradation of EGFR, leading to suppressed EGF‐induced anaplastic lymphoma receptor tyrosine kinase phosphorylation. In addition, the downregulation of AP1S1 increased the sensitivity of H1975 cancer cells, which are resistant to tyrosine kinase inhibitors, to erlotinib. Collectively, our results suggest that AP1S1 could regulate EGFR recycling under stiff matrix conditions, and AP1S1 inhibition could be a novel strategy for treating cancer cells resistant to EGFR‐targeted anticancer drugs.
Development and evaluation of an educational resource for parents of children with 22q11.2 deletion syndrome about the psychiatric manifestations of the condition
Authors: Blankenship Kayla , Chieffo Stephanie , Morris Emily , Slomp Caitlin , Batallones Rolan , Prijoles Eloise , Hill‐Chapman Crystal , Austin Jehannine 
Published: September 2023

AbstractParents of children with 22q11.2 deletion syndrome (22q11DS) report concern about the psychiatric manifestations of the condition, but typically receive little information about this in clinical encounters and instead find information about it elsewhere. We developed an educational booklet about the psychiatric manifestations of 22q11DS and assessed its utility among parents of children with the condition. First, six parents of individuals with 22q11DS completed cognitive interviews to review an established generic booklet about the genetics of psychiatric conditions—and to suggest 22q11DS‐specific adaptations. We used these suggestions to develop a novel booklet specific to psychiatric conditions and 22q1DS. Then, before and 1‐month after reading the novel 22q11DS‐specific online booklet, 73 parents of children with 22q11DS (with/without psychiatric conditions) completed validated scales (measuring empowerment, stigma, intolerance of uncertainty), an adapted version of a scale measuring worry about their child developing psychiatric illness, and purpose‐designed items assessing perceptions of understanding of 22q11DS and mental illness, confidence in recognizing early signs, etc. After reading the 22q11DS online booklet, participants' feelings of empowerment increased (p = 0.002), while feelings of worry about their child developing psychiatric illness decreased (p = 0.05), and they reported better understanding 22q11DS and mental illness, and increased confidence in recognizing early warning signs. There is potential benefit in broadly distributing this educational booklet to parents of children with 22q11DS.
Impact of antithrombotic therapy on postpancreatectomy hemorrhage in 7116 patients: A project study by the Japanese Society of Hepato‐Biliary‐Pancreatic Surgery
Authors: Nakamura Kota , Nagai Minako , Matsumoto Ippei , Satoi Sohei , Motoi Fuyuhiko , Kawai Manabu , Hosouchi Yasuo , Higuchi Ryota , Mizuno Shugo , Ohtsuka Takao , Akahoshi Keiichi , Hakamada Kenichi , Unno Michiaki , Yamaue Hiroki , Nakamura Masafumi , Endo Itaru , Sho Masayuki 
Published: September 2023

AbstractBackgroundWe previously reported an association between antithrombotic therapy and an increased risk of postpancreatectomy hemorrhage (PPH). To validate our findings, we conducted a large‐scale multicenter retrospective study from 63 high‐volume centers in Japan.MethodsBetween 2015 and 2018, 7116 patients who underwent pancreatectomy were enrolled. The antithrombotic group consisted of 920 patients (12.9%) who received preoperative antithrombotic agents including aspirin, clopidogrel, ticlopidine, prasugrel, warfarin, and direct oral anticoagulants.ResultsPPH occurred in 235 (3.3%) of the patients. The incidence of PPH and mortality were significantly higher in the antithrombotic group than in the control group (5.7 vs. 3.0% and 2.2 vs. 0.9%, respectively; both p < .001). In multivariate analysis, a history of antithrombotic use was an independent risk factor for grade C PPH (p = .036). In the antithrombotic group, PPH tended to be delayed in the patients with restarting antithrombotic therapy. Notably, the occurrence of delayed PPH after restarting antithrombotic therapy was observed only when antithrombotic therapy was restarted within 10 days after pancreatectomy.ConclusionsThis multicenter study demonstrated that a history of antithrombotic use was a significant risk factor for PPH and mortality. In particular, the resumption of antithrombotic therapy in the early postoperative period should be done with caution.
Cheminformatics and systems pharmacology approaches to unveil the potential plant bioactives to combat COVID‐19
Authors: Muralitharan Dhivyadharshini , Varadharajan Venkatramanan , Venkidasamy Baskar 
Published: September 2023

AbstractCOVID‐19 was a global pandemic in the year 2020. Several treatment options failed to cure the disease. Thus, plant‐based medicines are becoming a trend nowadays due to their less side effects. Bioactive chemicals from natural sources have been utilised for centuries as treatment options for a variety of ailments. To find out the potent bioactive compounds to counteract COVID‐19, we use systems pharmacology and cheminformatics. They use the definitive data and predict the possible outcomes. In this study, we collected a total of 72 phytocompounds from the medicinally important plants such as Garcinia mangostana and Cinnamomum verum, of which 13 potential phytocompounds were identified to be active against the COVID‐19 infection based on Swiss Target Prediction and compound target network analysis. These phytocompounds were annotated to identify the specific human receptor that targets COVID‐19‐specific genes such as MAPK8, MAPK14, ACE, CYP3A4, TLR4 and TYK2. Among these, compounds such as smeathxanthone A, demethylcalabaxanthone, mangostanol, trapezifolixanthone from Garcinia mangostana and camphene from C. verum were putatively target various COVID‐19‐related genes. Molecular docking results showed that smeathxanthone A and demethylcalabaxanthone exhibit increased binding efficiency towards the COVID‐19‐related receptor proteins. These compounds also showed efficient putative pharmacoactive properties than the commercial drugs ((R)‐remdesivir, favipiravir and hydroxychloroquine) used to cure COVID‐19. In conclusion, our study highlights the use of cheminformatics approach to unravel the potent and novel phytocompounds against COVID‐19. These phytocompounds may be safer to use, more efficient and less harmful. This study highlights the value of natural products in the search for new drugs and identifies candidates with great promise.
Blood–Brain Barrier Disruption and Perivascular Spaces in Small Vessel Disease and Neurodegenerative Diseases: A Review on MRI Methods and Insights
Authors: Voorter Paulien H. M. , van Dinther Maud , Jansen Willemijn J. , Postma Alida A. , Staals Julie , Jansen Jacobus F. A. , van Oostenbrugge Robert J. , van der Thiel Merel M. , Backes Walter H. 
Published: September 2023

Perivascular spaces (PVS) and blood–brain barrier (BBB) disruption are two key features of cerebral small vessel disease (cSVD) and neurodegenerative diseases that have been linked to cognitive impairment and are involved in the cerebral waste clearance system. Magnetic resonance imaging (MRI) offers the possibility to study these pathophysiological processes noninvasively in vivo. This educational review provides an overview of the MRI techniques used to assess PVS functionality and BBB disruption. MRI‐visible PVS can be scored on structural images by either (subjectively) counting or (automatically) delineating the PVS. We highlight emerging (diffusion) techniques to measure proxies of perivascular fluid and its movement, which may provide a more comprehensive understanding of the role of PVS in diseases. For the measurement of BBB disruption, we explain the most commonly used MRI technique, dynamic contrast‐enhanced (DCE) MRI, as well as a more recently developed technique based on arterial spin labeling (ASL). DCE MRI and ASL are thought to measure complementary characteristics of the BBB. Furthermore, we describe clinical studies that have utilized these MRI techniques in cSVD and neurodegenerative diseases, particularly Alzheimer's disease (AD). These studies demonstrate the role of PVS and BBB dysfunction in these diseases and provide insight into the large overlap, but also into the differences between cSVD and AD. Overall, MRI techniques may provide valuable insights into the pathophysiological mechanisms underlying these diseases and have the potential to be used as markers for disease progression and treatment response.Level of Evidence3Technical EfficacyStage 2
The role of indium composition in InxGa1−xN prestrained layer towards optical characteristics of EBL free GaN/InGaN nanowire LEDs for enhanced luminescence
Authors: Das Samadrita , Lenka Trupti Ranjan , Talukdar Fazal Ahmed , Nguyen Hieu Pham Trung , Crupi Giovanni 
Published: September 2023

AbstractIn this work, an electron blocking layer (EBL) free light emitting diode (LED) nanowire is proposed with alternate prestrained layers of InxGa1−xN/GaN, which are inserted between the GaN/InGaN multi‐quantum wells (MQWs) and n‐GaN layer. This study signifies the role of prestrained layers on the piezoelectric polarization of LED nanowires, for enhanced luminescence. When compared with the conventional one, the EBL free LED nanowire with prestrained layer shows an enhancement of ~2.897% efficiency, which occurs due to the reduction of polarization field in the active region. The LED with 15% indium in the prestrained layer obtains a maximum efficiency of 85.21% along with a minimum efficiency droop of 3.848% at 40 mA injected current. The proposed III‐nitride LED nanostructure allows for achieving superior optical power across the output spectral range.
FOXA1 prolongs S phase and promotes cancer progression in non‐small cell lung cancer through upregulation of CDC5L and activation of the ERK1/2 and JAK2 pathways
Authors: Chen Gang , Wei Rui‐Shi , Ma Jie , Li Xin‐Hua , Feng Li , Yu Jian‐Rong 
Published: September 2023

AbstractNon‐small cell lung cancer (NSCLC) causes high mortality worldwide; however, its molecular pathways have not been fully investigated. The relationship between FOXA1 and CDC5L as well as their roles in NSCLC have not been comprehensively studied. Clinical tissues were collected from 78 NSCLC patients for clinical studies. The BEAS‐2B human normal lung epithelial cell line and the A549, Calu‐3, H526 and H2170 human NSCLC cell lines were used for in vitro studies. sh‐FOXA1 and oe‐CDC5L constructs were used to generate knockdown and overexpression models, respectively. The CCK‐8 assay was used to analyze cell viability. The cell cycle and apoptosis were evaluated by flow cytometry analysis. The relationship between FOXA1 and CDC5L was demonstrated using dual‐luciferase and ChIP assays. Gene levels were examined via immunohistochemistry, qRT‐PCR and western blot analysis. FOXA1 levels were increased in NSCLC clinical tissues and cell lines. Depletion of FOXA1 increased the apoptosis rate and increased the proportion of cells in G2/M phase. In addition, we demonstrated that FOXA1 was directly bound to the promoter of CDC5L and that depletion of FOXA1 inhibited CDC5L expression. Overexpression of CDC5L induced ERK1/2 phosphorylation, induced JAK2 phosphorylation, inhibited cell apoptosis, prolonged S phase, and significantly reversed the effects of FOXA1 knockdown on the progression of NSCLC. The present study demonstrated that FOXA1 prolongs S phase and promotes NSCLC progression through upregulation of CDC5L and activation of the ERK1/2 and JAK2 pathways.
Unawareness of hepatitis B infection and lack of surveillance are associated with severity of hepatocellular carcinoma
Authors: Lee Kuan‐I , Liang Po‐Cheng , Hsu Po‐Yau , Jang Tyng‐Yuan , Wei Yu‐Ju , Huang Ching‐I , Hsieh Ming‐Yen , Lin Zu‐Yau , Yeh Ming‐Lun , Huang Chung‐Feng , Huang Jee‐Fu , Dai Chia‐Yen , Chuang Wan‐Long , Yu Ming‐Lung 
Published: September 2023

AbstractUnawareness of hepatitis B virus (HBV) infection and lack of surveillance may serve as major barriers to HBV control and contributors to severe hepatocellular carcinoma (HCC) at presentation. This study evaluated the risk of HBV unawareness and its relationship with HCC severity. This retrospective study was conducted in a tertiary hospital in Taiwan. Patients with HBV‐related HCC diagnosed from 2011 to 2021 were enrolled. The demographic, clinical, and HCC characteristics were collected and compared between patients with HBV unawareness and awareness with and without surveillance. Of 501 HBV‐related HCC patients enrolled, 105 (21%) patients were unaware of HBV infection at the time of HCC diagnosis. Patients with HBV unawareness were significantly younger and had poorer liver function than those with HBV awareness. Patients with HBV unawareness also had a significantly higher rate of detectable HBV DNA and an advanced stage of HCC. Ninety‐one (23%) of the HBV‐aware patients did not receive regular surveillance. Patients with HBV unawareness and awareness without surveillance shared similar clinical characteristics with more severe HCC status. Further regression analysis demonstrated that HBV awareness with periodic surveillance was associated with early stage HCC. Meanwhile, we observed that there was no change in the proportion of HBV awareness over the past 10 years. Patients with surveillance also had better HCC survival than patients without surveillance or unawareness. HBV unawareness and lack of regular surveillance correlated with advanced HCC at presentation. Efforts to improve HBV education, disease awareness, and HCC surveillance are needed.
Compare the effectiveness of extracorporeal shockwave and hyperbaric oxygen therapy on enhancing wound healing in a streptozotocin‐induced diabetic rodent model
Authors: Chen Rong‐Fu , Lin Yun‐Nan , Liu Keng‐Fan , Lee Chia‐Chun , Hu Chieh‐Ju , Wang Chun‐Ting , Wang Ching‐Jen , Kuo Yur‐Ren 
Published: September 2023

AbstractStudies have revealed that both extracorporeal shock‐wave therapy (ESWT) and hyperbaric oxygen therapy (HBOT) can accelerate wound healing. This study aimed to compare the effectiveness of ESWT and HBOT in enhancing diabetic wound healing. A dorsal skin defect in a streptozotocin‐induced diabetes rodent model was used. Postoperative wound healing was assessed once every 3 days. Histologic examination was performed with hematoxylin and eosin staining. Proliferation marker protein Ki‐67 (Ki‐67), endothelial nitric oxide synthase (eNOS), vascular endothelial growth factor (VEGF), and 8‐hydroxy‐2‐deoxyguanosine (8‐OHdG) were evaluated with immunohistochemical (IHC) staining. The wound area was significantly reduced in the ESWT and HBOT groups compared to that in the diabetic controls. However, the wound healing time was significantly increased in the HBOT group compared to the ESWT group. Histological findings showed a statistical increase in neovascularization and suppression of the inflammatory response by both HBOT and ESWT compared to the controls. IHC staining revealed a significant increase in Ki‐67, VEGF, and eNOS but suppressed 8‐OHdG expression in the ESWT group compared to the HBOT group. ESWT facilitated diabetic wound healing more effectively than HBOT by suppressing the inflammatory response and enhancing cellular proliferation and neovascularization and tissue regeneration.
Environmental Sustainability: Waste Audit Comparison Operating Roomand In‐Office Laryngeal Surgery
Authors: Anderson Jennifer , Hu Huixin 
Published: September 2023

IntroductionWith vast improvements in imaging and endoscopic technology, there has been a massive shift towards in office procedures for various laryngeal disorders with significant health system and patient benefits. Another benefit which has yet to be investigated is the potential environmental effects and waste reduction of in‐office laryngeal procedures over traditional operating room surgery.ObjectivesThe purpose of this study is to perform a waste audit and compare the results between operating room and in‐office laser laryngeal surgery.MethodsTen cases of in‐office and operating room laser laryngeal surgery, performed for recurrent respiratory papillomatosis, were subjected to a waste audit with four waste streams identified. Recyclable, general waste, anesthesia source and sharps. All waste was included from the time of case preparation to termination.ResultsThe cases were extremely homogeneous in the waste produced. The mean waste total produced for the operating room laser surgery was 2972 g of which 18% was recoverable/recyclable. Contamination rate was very low. Recycling was performed very well by nursing/prep staff; however, anesthesia was not recovering 13% of potential materials.The in‐office waste produced was approximately one tenth of the operating room waste with almost all delegated into general waste. Potentially divertible/recyclable materials accounted for 38% of the waste in‐office procedures.ConclusionsIn‐office laryngeal procedures produce 13% of waste compared to surgery performed for similar pathology. These procedures are cost effective, safe and have been demonstrated to enhance environmental sustainability.Level of EvidenceNA Laryngoscope, 134:803–806, 2024
A Pilot Study of Decellularized Cartilage for Laryngotracheal Reconstruction in a Neonatal Pig Model
Authors: Gehret Paul M. , Dumas Alexandra A. , Jacobs Ian N. , Gottardi Riccardo 
Published: September 2023

ObjectiveSevere subglottic stenosis develops as a response to intubation in 1% of the >200,000 neonatal intensive care unit infants per year and may require laryngotracheal reconstruction (LTR) with autologous hyaline cartilage. Although effective, LTR is limited by comorbidities, severity of stenosis, and graft integration. In children, there is a significant incidence of restenosis requiring revision surgery. Tissue engineering has been proposed to develop alterative grafting options to improve outcomes and eliminate donor‐site morbidity. Our objective is to engineer a decellularized, channel‐laden xenogeneic cartilage graft, that we deployed in a proof‐of‐concept, neonatal porcine LTR model.MethodsMeniscal porcine cartilage was freeze–thawed and washed with pepsin/elastase to decellularize and create microchannels. A 6 × 10‐mm decellularized cartilage graft was then implanted in 4 infant pigs in an anterior cricoid split. Airway patency and host response were monitored endoscopically until sacrifice at 12 weeks, when the construct phenotype, cricoid expansion, mechanics, and histomorphometry were evaluated.ResultsThe selective digestion of meniscal components yielded decellularized cartilage with cell‐size channels. After LTR with decellularized meniscus, neonatal pigs were monitored via periodic endoscopy observing re‐epithelization, integration, and neocartilage formation. At 12 weeks, the graft appeared integrated and exhibited airway expansion of 4 mm in micro‐CT and endoscopy. Micro‐CT revealed a larger lumen compared with age‐matched controls. Finally, histology showed significant neocartilage formation.ConclusionOur neonatal porcine LTR model with a decellularized cartilage graft is a novel approach to tissue engineered pediatric LTR. This pilot study sets the stage for “off‐the‐shelf” graft procurement and future optimization of MEND for LTR.Level of EvidenceNA Laryngoscope, 134:807–814, 2024
Survival Benefit from Cancer‐Directed Surgery for Metastatic Head and Neck Cancer
Authors: Zhu Runqiu , Zhu Huiyong 
Published: September 2023

ObjectivesThis study aimed to gather evidence for the survival benefit of cancer‐directed surgery (CDS) in metastatic head and neck cancer (M1 HNC) and identify which patients will benefit most from CDS.MethodsPatients with M1 HNC were identified within the SEER database. According to whether received CDS, patients were divided into the CDS and non‐CDS groups. The bias between the two groups was minimized using Propensity Score Matching (PSM), and the prognostic role of CDS was investigated using Kaplan–Meier analysis, log‐rank test, and Cox proportional hazard models. The primary endpoint was overall survival (OS), and the secondary endpoint was cancer‐specific survival (CSS).ResultsA total of 3215 patients with M1 HNC were extracted, including 566 patients who received CDS that were 1:1 propensity score‐matched with patients who did not receive CDS. In the matched dataset, the median OS and CSS in CDS groups were significantly higher than in non‐CDS groups (OS: 19.0 vs. 9.0 months, p < 0.001; CSS: 21.0 vs. 9.0 months, p < 0.001). Meanwhile, multivariable Cox regression analysis also revealed that CDS was a favorable prognostic factor for both OS and CSS. Furthermore, subgroups of patients with M1 HNC (younger age, being married, grade I–II, oropharynx site, earlier T/N stage, radiotherapy) were inclined to benefit from CDS, while those patients who received chemotherapy failed to benefit from CDS.ConclusionsThis study indicated that CDS was associated with improved survival in M1 HNC, especially for those subpopulations that benefit more from CDS treatment.Level of Evidence3 Laryngoscope, 134:1288–1298, 2024