bluuebunny/crossref_metadata_2025_split huggingface dataset:
ZILVERPASS Study: ZILVER PTX Stent versus Prosthetic Above-the-Knee Bypass Surgery in Femoropopliteal Lesions, 5-year Results
Authors: Bosiers Michel J. , De Donato Gianmarco , Torsello Giovanni , Silveira Pierre Galvagni , Scheinert Dierk , Veroux Pierfrancesco , Hendriks Jeroen , Maene Lieven , Keirse Koen , Navarro Tulio , Eckstein Hans-Henning , Teβarek Jörg , Giaquinta Alessia , van den Eynde Wouter , Verbist Jürgen , Callaert Joren , Deloose Koen , Bosiers Marc 
Published: September 2023

Abstract
Purpose
To report the 60-month safety and effectiveness results of a multicenter, prospective, randomized controlled trial comparing the ZILVER PTX paclitaxel-eluting stent to prosthetic above-the-knee bypass for the treatment of symptomatic TransAtlantic Inter-Society Consensus (TASC) C and D femoropopliteal lesions.

Materials and methods
Patients were enrolled between October 2013 and July 2017. One of the secondary outcomes was primary patency at 60 months, defined as no evidence of binary restenosis or occlusion within the target lesion or bypass graft based on a duplex ultrasound peak systolic velocity ratio < 2.4 and no clinically-driven target lesion revascularization (TLR) in endovascular cases or reintervention to restore flow in the bypass at 60 months. Survival rates after 5 years were also analyzed.

Results
220 patients (mean age 68.6 ± 10.5 years; 159 men) were included and randomized to ZILVER PTX (n = 113, 51.40%) or BYPASS group (n = 107, 48.60%). The 60-month primary patency rate was 49.3% for the ZILVER PTX group versus 40.7% for the bypass group (p = 0.6915). Freedom from TLR was 63.8% for the ZILVER PTX group versus 52.8% for the bypass group (p = 0.2637). At 5 years, no significant difference in survival rate could be seen between the ZILVER PTX and the bypass group (69.1% vs. 71% respectively, p = 0.5503).

Conclusion
Even at 5 years, non-inferior safety and effectiveness results of the ZILVER PTX could be seen. These findings confirmed that the use of ZILVER PTX stents can be considered as a valid alternative for bypass surgery when treating long and complex femoropopliteal lesions.

Graphical Abstract
Axo-glial interactions between midbrain dopamine neurons and oligodendrocyte lineage cells in the anterior corpus callosum
Authors: Caldwell Megan , Ayo-Jibunoh Vanessa , Mendoza Josue Criollo , Brimblecombe Katherine R. , Reynolds Lauren M. , Zhu Jiang Xin Yan , Alarcon Colin , Fiore Elizabeth , N. Tomaio Jacquelyn , Phillips Greg R. , Mingote Susana , Flores Cecilia , Casaccia Patrizia , Liu Jia , Cragg Stephanie J. , McCloskey Dan P. , Yetnikoff Leora 
Published: September 2023

AbstractOligodendrocyte progenitor cells (OPCs) receive synaptic innervation from glutamatergic and GABAergic axons and can be dynamically regulated by neural activity, resulting in activity-dependent changes in patterns of axon myelination. However, it remains unclear to what extent other types of neurons may innervate OPCs. Here, we provide evidence implicating midbrain dopamine neurons in the innervation of oligodendrocyte lineage cells in the anterior corpus callosum and nearby white matter tracts of male and female adult mice. Dopaminergic axon terminals were identified in the corpus callosum of DAT-Cre mice after injection of an eYFP reporter virus into the midbrain. Furthermore, fast-scan cyclic voltammetry revealed monoaminergic transients in the anterior corpus callosum, consistent with the anatomical findings. Using RNAscope, we further demonstrate that ~ 40% of Olig2 + /Pdfgra + cells and ~ 20% of Olig2 + /Pdgfra- cells in the anterior corpus callosum express Drd1 and Drd2 transcripts. These results suggest that oligodendrocyte lineage cells may respond to dopamine released from midbrain dopamine axons, which could affect myelination. Together, this work broadens our understanding of neuron-glia interactions with important implications for myelin plasticity by identifying midbrain dopamine axons as a potential regulator of corpus callosal oligodendrocyte lineage cells.
High expression of NOLC1 as an independent prognostic factor for survival in patients with colorectal cancer
Authors: Sun Zhiwei , Zhang Qianshi , lv Jinjuan , Sun Yuzhu , Feng Zhen , Zhang Mengyan , Zhang Feifan , Xia Cong , Gao Yina , Zhang Zhenyu , Zuo Yun-Fei , Ren Shuang-Yi 
Published: September 2023

Abstract
Background
As a phosphorylated protein, NOLC1 is mainly located in the nucleus and is highly expressed in a variety of tumors, participating in the regulation of cell proliferation and aging. This study further investigated the role of NOLC1 in colorectal cancer tumors, aiming to provide sufficient scientific evidence for the clinical treatment of colorectal cancer.

Methods
We used TCGA, GEO, TNMplot, GEPIA, and other databases to explore the expression level of NOLC1 in colorectal cancer patients, as well as the correlation between the clinical characteristics of colorectal cancer patients and their expression, and conducted the prognostic analysis. Immunohistofluorescence (IHF) staining verified the analytical results. Subsequently, KEGG and GO enrichment analysis was used to identify the potential molecular mechanism of NOLC1 promoting the occurrence and development of colorectal cancer. The influence of NOLC1 expression on the immune microenvironment of colorectal cancer patients was further investigated using the TIMER database. GDSC database analysis was used to screen out possible anti-colorectal cancer drugs against NOLC1. Finally, we demonstrated the effect of NOLC1 on the activity and migration of colorectal cancer cells by Edu Cell proliferation assay and Wound Healing assay in vitro.

Results
Our results suggest that NOLC1 is overexpressed in colorectal cancer, and that overexpression of NOLC1 is associated with relevant clinical features. NOLC1, as an independent risk factor affecting the prognosis of colorectal cancer patients, can lead to a poor prognosis of colorectal cancer. In addition, NOLC1 may be associated with MCM10, HELLS, NOC3L, and other genes through participating in Wnt signaling pathways and jointly regulate the occurrence and development of colorectal cancer under the influence of the tumor microenvironment and many other influencing factors. Related to NOLC1: Selumetinib, Imatinib, and targeted drugs such as Lapatinib have potential value in the clinical application of colorectal cancer. NOLC1 enhances the proliferation and migration of colorectal cancer cells.

Conclusions
High expression of NOLC1 as an independent prognostic factor for survival in patients with colorectal cancer. NOLC1 enhances the proliferation and migration of colorectal cancer cells. Further studies and clinical trials are needed to confirm the role of NOLC1 in the development and progression of colorectal cancer.
U–Pb zircon age and chronology of the Torfufell central volcano: implications for timing of rift relocation in North Iceland
Authors: Árnadóttir Sigurveig , Thordarson Thor , Hjartarson Árni , Gautason Bjarni 
Published: September 2023

AbstractThe Late-Miocene Torfufell central volcano (ToCV), situated between the now extinct Snæfellsnes-Húnaflói rift zone and the presently active rift in North Iceland, provides an excellent opportunity to recreate the construction history of a volcanic edifice. We present new U–Pb zircon ages from six silicic units of the ToCV. The results range from 7.15 ± 0.12 to 6.76 ± 0.02 Ma, taken here to represent a ~ 400 kyr time-span for silicic activity at the volcano. Before that, the central volcano had produced basaltic lavas for 600–800 kyr, implying that it was active for ~ 1–1.2 Myr. A stratigraphically documented ~ 1 Myr hiatus above the volcano is contemporaneous with, but shorter than, a major unconformity in the Flateyjarskagi peninsula, considered to result from a major rift relocation in North Iceland. The new U–Pb ages show that silicic volcanism at the ToCV took place 1–2 Myr earlier than assumed previously and nearly synchronously with the rift relocation. As the age progression of the ToCV and the neighboring 5–6 Ma Tinná central volcano conflicts with the generally established geotectonic framework of central N-Iceland, we propose that these two volcanoes were formed at a leaky transform zone that developed to accommodate the rift relocation, with the ToCV formed at its junction with the embryonic rift zone, thus marking the initiation of the presently active rift in North Iceland. Since then, the two volcanoes have drifted away from the rift system due to plate spreading and migration of the plate boundary relative to the Iceland mantle plume.
Characterising the wind-advected medial fall deposit from fissure 8 fountaining during the 2018 lower East Rift Zone eruption, Kīlauea
Authors: Watts Emma J. , Cockshell Wendy A. , Houghton Bruce F. 
Published: September 2023

AbstractThe 2018 eruption on the lower East Rift Zone, Hawaii, involved the opening of 24 fissures before the eruption focussed on a single point source, fissure 8 (F8). This study characterises the preserved medial F8 tephra deposit using an isopach map, maximum clast size data, and total grain size distribution analysis, shedding light on the tephra transport and dispersal mechanisms beyond the F8 cone occurring during the fountaining. The medial sheet-like deposit covers approximately 0.22 km2, best fit by a Power-Law thinning rate. The TephraFits model estimated the corresponding volume of the continuous medial tephra blanket to be ~ 2 $$\times$$
×
104 m3, just 0.02% of the total volume erupted from fissure 8. Samples from the preserved medial deposit have grain size modes of − 3.5 to − 4 Φ, compatible with Voronoi tessellation calculations. Maximum clast size did not show a ‘typical’ fining relationship with distance from the vent; instead, it shows no clear pattern. One factor was that the extremely low clast density, a function of a secondary vesiculation event, enabled the pyroclasts to be re-entrained, often repeatedly, by large eddies downwind of the vent. This should be considered in future studies of prolonged fountaining episodes as the clasts involved in the medial fall are rarely well preserved in the geologic record due to their fragile nature but their presence adds complexity to the inferred eruption dynamics.
The Online Broadcast Range-Assignment Problem
Authors: de Berg Mark , Markovic Aleksandar , Umboh Seeun William 
Published: September 2023

AbstractLet $$P=\{p_0,\ldots ,p_{n-1}\}$$

P
=
{

p
0

,
…
,

p

n
-
1

}

be a set of points in $${\mathbb R}^d$$

R

d

, modeling devices in a wireless network. A range assignment assigns a range $$r(p_i)$$

r
(

p
i

)

to each point $$p_i\in P$$

p
i

∈
P

, thus inducing a directed communication graph $$\mathcal {G}_r$$

G
r

in which there is a directed edge $$(p_i,p_j)$$

(

p
i

,

p
j

)

iff $${{\,\textrm{dist}\,}}(p_i, p_j) \leqslant r(p_i)$$

dist

(

p
i

,

p
j

)

⩽
r

(

p
i

)

, where $${{\,\textrm{dist}\,}}(p_i,p_j)$$

dist

(

p
i

,

p
j

)

denotes the distance between $$p_i$$

p
i

and $$p_j$$

p
j

. The range-assignment problem is to assign the transmission ranges such that $$\mathcal {G}_r$$

G
r

has a certain desirable property, while minimizing the cost of the assignment; here the cost is given by $$\sum _{p_i\in P} r(p_i)^{\alpha }$$

∑

p
i

∈
P

r

(

p
i

)

α

, for some constant $$\alpha >1$$

α
>
1

called the distance-power gradient. We introduce the online version of the range-assignment problem, where the points $$p_j$$

p
j

arrive one by one, and the range assignment has to be updated at each arrival. Following the standard in online algorithms, resources given out cannot be taken away—in our case this means that the transmission ranges will never decrease. The property we want to maintain is that $$\mathcal {G}_r$$

G
r

has a broadcast tree rooted at the first point $$p_0$$

p
0

. Our results include the following.

We prove that already in $${\mathbb R}^1$$

R

1

, a 1-competitive algorithm does not exist. In particular, for distance-power gradient $$\alpha =2$$

α
=
2

any online algorithm has competitive ratio at least 1.57.

For points in $${\mathbb R}^1$$

R

1

and $${\mathbb R}^2$$

R

2

, we analyze two natural strategies for updating the range assignment upon the arrival of a new point $$p_j$$

p
j

. The strategies do not change the assignment if $$p_j$$

p
j

is already within range of an existing point, otherwise they increase the range of a single point, as follows: Nearest-Neighbor (nn) increases the range of $${{\,\textrm{nn}\,}}(p_j)$$

nn

(

p
j

)

, the nearest neighbor of $$p_j$$

p
j

, to $${{\,\textrm{dist}\,}}(p_j, {{\,\textrm{nn}\,}}(p_j))$$

dist

(

p
j

,

nn

(

p
j

)

)

, and Cheapest Increase (ci) increases the range of the point $$p_i$$

p
i

for which the resulting cost increase to be able to reach the new point $$p_j$$

p
j

is minimal. We give lower and upper bounds on the competitive ratio of these strategies as a function of the distance-power gradient $$\alpha $$
α
. We also analyze the following variant of nn in $${\mathbb R}^2$$

R

2

for $$\alpha =2$$

α
=
2

: 2-Nearest-Neighbor (2-nn) increases the range of $${{\,\textrm{nn}\,}}(p_j)$$

nn

(

p
j

)

to $$2\cdot {{\,\textrm{dist}\,}}(p_j,{{\,\textrm{nn}\,}}(p_j))$$

2
·

dist

(

p
j

,

nn

(

p
j

)

)

,

We generalize the problem to points in arbitrary metric spaces, where we present an $$O(\log n)$$

O
(
log
n
)

-competitive algorithm.
The neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) levels following erector spinae plane block (ESPB) in posterior lumbar decompression: a randomized, controlled trial
Authors: Domagalska Małgorzata , Ciftsi Bahadir , Janusz Piotr , Reysner Tomasz , Kolasinski Jerzy , Wieczorowska - Tobis Katarzyna , Kowalski Grzegorz 
Published: September 2023

Abstract
Purpose
Neutrophile-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are the inflammatory biomarkers of the stress response. In this study, we aimed to evaluate the effects of erector spinae plane block (ESPB) on posterior lumbar decompression and stabilization by comparing NLR, PLR, postoperative pain, opioid consumption, and functional recovery between sham block and ESPB.

Methods
This was a prospective, double-blinded, randomized controlled trial in a tertiary referral hospital. Sixty patients were randomized into two equal groups, each receiving either a sham block or ESPB. The primary outcome was the NLR and PLR 12 h and 24 h after lumbar posterior decompression and stabilization. The secondary outcomes were total opioid consumption and pain score 24 h postoperatively. Also, functional recovery determined by getting out of bed, verticalization, and walking by the balcony were reviewed as secondary outcomes.

Results
Significant differences existed between the sham block and ESPB group in NLR (29.08 ± 12.29 vs. 16.97 ± 10.38; p < 0.0001) and PLR (556.77 ± 110.32 vs. 346.43 ± 117.34; p < 0.0001) 12 h after surgery. Also, there was a significant difference in NLR (p = 0.0466) and PLR (p < 0.0001) 24 h after surgery. In addition, there was a substantial difference in pain score, total opioid consumption, and functional recovery.

Conclusion
ESPB performance during spinal surgery lowers NRL and PLR ratios 12 h and 24 h after surgery. In addition, ESPB provides better analgesia and improves functional recovery compared to sham block following posterior lumbar decompression and stabilization.
Platelet-rich plasma for jumper's knee: a comprehensive review of efficacy, protocols, and future directions
Authors: Bosco Francesco , Giai Via Riccardo , Giustra Fortunato , Ghirri Alessandro , Cacciola Giorgio , Massè Alessandro 
Published: September 2023

Abstract
Purpose
This comprehensive review evaluates the current state of platelet-rich plasma (PRP) treatment for jumper's knee, also known as patellar tendinopathy. The aim is to assess the efficacy of PRP as a therapeutic option compared to other available procedures, investigate the benefits and potential drawbacks of PRP infiltration, and provide insights into the optimal protocols for PRP preparation and administration.

Methods
A comprehensive literature search of English articles published up to June 2023 was conducted using PubMed and Scopus databases. Studies evaluating PRP for treating jumper's knee or patellar tendinopathy were analyzed to assess the current state of research in this field.

Results
PRP has demonstrated promising results in promoting cellular remodeling and accelerating the healing process in the jumper's knee. It shows potential benefits in pain reduction, improved function, and accelerated recovery. However, the efficacy of PRP varies depending on patient characteristics, disease severity, and the specific administration methodology. Establishing standardized PRP preparation and administration protocols are necessary to optimize its effectiveness. Further research is needed to define appropriate patient selection criteria and refine the application of PRP therapy in patellar tendinopathy management.

Conclusion
Jumper's knee is commonly managed conservatively, but there is a lack of consensus on further treatment options. PRP treatment holds promise in promoting tissue healing and repair. However, standardized protocols for PRP preparation and administration, as well as optimal dosage and number of injections, require further investigation to enhance its efficacy. Continued research efforts are necessary to ascertain the precise role of PRP and its refinement in the management of patellar tendinopathy.
Simulation to determine the approach of transcatheter aortic valve implantation in patients undergoing hemodialysis
Authors: Takei Yusuke , Saito Shunsuke , Shibasaki Ikuko , Kuwata Toshiyuki , Yamada Yasuyuki , Fukuda Hirotsugu 
Published: September 2023

Abstract
Purpose
The present study investigated potential access vessels in patients receiving hemodialysis who underwent surgical aortic valve replacement and determined which approaches were most suitable for performing transcatheter aortic valve implantation.

Methods
Consecutive patients undergoing hemodialysis with aortic valve stenosis who underwent surgical aortic valve replacement were included. Preoperative computed tomography data were analyzed to assess the vessel diameter and calcification. Simulations were conducted to determine the feasibility of inserting the 14-F eSheath of Sapien 3 via transfemoral, trans-cervical, trans-subclavian, and direct aorta approaches.

Results
A total of 72 patients were included in this study. The access route was characterized by severe calcification of the common iliac artery. The transfemoral approach was feasible in 77.8% of the cases, but the rate decreased to 33% when the calculations were based on the maximum sheath extension diameter. The trans-cervical, trans-subclavian, and direct aortic approaches were suitable for many patients. Lower extremity artery disease was identified as a risk factor for the unsuitability of the transfemoral approach.

Conclusions
Common iliac artery calcification in patients undergoing hemodialysis restricts the use of the transfemoral approach. Therefore, some patients require alternative approaches.
When details are difficult to portray: enriching vision videos
Authors: Nagel Lukas , Schmedes Melanie , Ahrens Maike , Schneider Kurt 
Published: September 2023

AbstractThe creation of a shared understanding of the project vision of all relevant stakeholders is vital to the requirements engineering process. One way to create such a shared understanding is through the use of vision videos that visualize the project vision at an early project stage. However, not all functional aspects can be presented. For example, the fact that an access code is valid for only a single use can be hard to visualize. One low-effort solution could be the insertion of short texts or short audio clips. In this work, our question is twofold: What effects do short pieces of additional information have in vision videos? What are suitable ways to add this information to vision videos? To answer these research questions, we investigated three different methods of inserting additional information to vision videos in an eye tracking study. We inserted short texts either below the scene or as overlays and also investigated the addition of short audio clips. These methods were evaluated in terms of participants’ video comprehension, visual effort, cognitive load and subjective preference. The results of our study show that the pieces of additional information improve vision comprehension, thereby supporting the creation of a shared understanding. All investigated methods lead to only marginal increases of the viewers’ cognitive load. Based on our results, we derive recommendations on how to insert additional information in vision videos.
Impact of Drought on Ecohydrology of Southern California Grassland and Shrubland
Authors: Chavez Rodriguez Luciana , Parker Scot , Fiore Nicole M. , Allison Steven D. , Goulden Michael L. 
Published: September 2023

AbstractThrough their rooting profiles and water demands, plants affect the distribution of water in the soil profile. Simultaneously, soil water content controls plant development and interactions within and between plant communities. These plant-soil water feedbacks might vary across plant communities with different rooting depths and species composition. In semiarid environments, understanding these differences will be essential to predict how ecosystems will respond to drought, which may become more frequent and severe with climate change. In this study, we tested how plant-soil water feedbacks responded to drought in two contrasting ecosystem types—grassland and shrubland—in the coastal foothills of southern California. During years 5–8 of an ongoing precipitation manipulation experiment, we measured changes in plant communities and soil moisture up to 2 m depth. We observed different water use patterns in grassland and shrubland communities with distinct plant functional types and water use strategies. Drought treatment did not affect perennial, deep-rooted shrubs because they could access deep soil water pools. However, mid-rooted shrubs were sensitive to drought and experienced decreased productivity and die-off. As a result, water content actually increased with drought at soil depths from 50–150 cm. In grassland, biomass production by annual species, including annual grasses and forbs, declined with drought, resulting in lower water uptake from the surface soil layer. An opportunistic “live fast, die young“ life strategy allowed these species to recover quickly once water availability increased. Our results show how drought interacts with plant community composition to affect the soil water balance of semiarid ecosystems, information that could be integrated into global scale models.
Rapid prototyping of multi-compartment models for urea kinetics in hemodialysis: a System Dynamics approach
Authors: Rubin David M. , Letts Robyn F. R. , Richards Xriz L. , Achari Shamin , Pantanowitz Adam 
Published: September 2023

AbstractModels of urea kinetics facilitate a mechanistic understanding of urea transfer and provide a tool for optimizing dialysis efficacy. Dual-compartment models have largely replaced single-compartment models as they are able to accommodate the urea rebound on the cessation of dialysis. Modeling the kinetics of urea and other molecular species is frequently regarded as a rarefied academic exercise with little relevance at the bedside. We demonstrate the utility of System Dynamics in creating multi-compartment models of urea kinetics by developing a dual-compartment model that is efficient, intuitive, and widely accessible to a range of practitioners. Notwithstanding its simplicity, we show that the System Dynamics model compares favorably with the performance of a more complex volume-average model in terms of calibration to clinical data and parameter estimation. Its intuitive nature, ease of development/modification, and excellent performance with real-world data may make System Dynamics an invaluable tool in widening the accessibility of hemodialysis modeling.