bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effectiveness of mRNA COVID-19 Vaccines and Hybrid Immunity in Preventing SARS-CoV-2 Infection and Symptomatic COVID-19 Among Adults in the United States
Authors: Feldstein Leora R , Ruffin Jasmine , Wiegand Ryan E , Borkowf Craig B , James-Gist Jade , Babu Tara M , Briggs-Hagen Melissa , Chappell James , Chu Helen Y , Englund Janet A , Kuntz Jennifer L , Lauring Adam S , Lo Natalie , Carone Marco , Lockwood Christina , Martin Emily T , Midgley Claire M , Monto Arnold S , Naleway Allison L , Ogilvie Tara , Saydah Sharon , Schmidt Mark A , Schmitz Jonathan E , Smith Ning , Sohn Ine , Starita Lea , Talbot H Keipp , Weil Ana A , Grijalva Carlos G 
Published: January 2025

Abstract

Background
Understanding protection against SARS-CoV-2 infection by vaccine and hybrid immunity is important for informing public health strategies as new variants emerge.

Methods
We analyzed data from 3 cohort studies spanning 1 September 2022 to 31 July 2023 to estimate COVID-19 vaccine effectiveness (VE) against SARS-CoV-2 infection and symptomatic COVID-19 among adults with and without prior infection in the United States. Participants collected weekly nasal swabs irrespective of symptoms, participated in annual blood draws, and completed periodic surveys, which included vaccination status and infection history. Swabs were tested molecularly for SARS-CoV-2. VE was estimated by Cox proportional hazards models for the hazard ratios of infections, adjusting for covariates. VE was calculated considering prior infection and recency of vaccination.

Results
Among 3344 adults, the adjusted VE of a bivalent vaccine against infection was 37.2% (95% CI, 12.3%–55.7%) within 7 to 59 days of vaccination and 21.1% (95% CI, −0.5% to 37.1%) within 60 to 179 days of vaccination when compared with participants who were unvaccinated or had received an original monovalent vaccine dose ≥180 days prior. Overall, the adjusted VE of a bivalent vaccine against infection, in conjunction with prior infection, was 62.2% (95% CI, 46.0%–74.5%) within 7 to 179 days of vaccination and 39.4% (95% CI, 12.5%–61.6%) at ≥180 days when compared with naive participants who were unvaccinated or had received a monovalent vaccine dose ≥180 days prior.

Conclusions
Adults with prior infection and recent vaccination had high protection against infection and symptomatic illness. Recent vaccination alone provided moderate protection.
Safety and efficacy of long-acting cabotegravir/rilpivirine versus standard oral antiretroviral therapy: a systematic review and meta-analysis
Authors: Manalu Samuel Bungaran Partahi Saud , Perez Navarro Andrea , Fairhead Cassandra , Hill Andrew 
Published: January 2025

Abstract

Background
In 2023, there were 39.9 million people living with HIV (PLWH) worldwide and 630 000 deaths related to HIV. New strategies are needed, and long-acting antiretrovirals (LAAs) are now widely considered to have great potential to help end the HIV epidemic. This systematic review and meta-analysis compare the safety and efficacy of LAA versus standard oral treatment (SOT) for HIV.

Methods
PubMed and Embase databases, supplemented by ClinicalTrials.gov and grey literature, were searched. Randomized controlled trials (RCTs) reporting efficacy and/or safety of LAA versus SOT for PLWH until June 2024 were included. Efficacy (HIV RNA &lt; 50 copies/mL) and HIV RNA ≥ 50 copies/mL, adverse events (AEs), treatment discontinuation, CD4 count, metabolic parameters and drug resistance were assessed. Prespecified subgroup analyses were conducted. The risk of bias was assessed with Cochrane RoB 2.0. Certainty of evidence was assessed using GRADE.

Results
Six RCTs were eligible for inclusion, involving 2829 participants. LAA was non-inferior to SOT in suppressing HIV RNA &lt; 50 copies/mL [Risk Difference (RD), −0.00; 95% CI, −0.03–0.02; P = 0.83; I2 = 51%; high quality of evidence (QoE)]. LAA was associated with higher drug resistance (percentage pooled estimate, 57%; 95% CI, 33%–78% versus 9%; 95% CI, 2%–30%; moderate QoE) and risk of grade 1–4 AEs than SOT [Risk Ratio (RR), 1.22; 95% CI, 1.12–1.33; P &lt; 0.001; I2 = 62%; moderate QoE].

Conclusions
LAA has non-inferior efficacy compared to SOT. However, participants receiving LAA were at a higher risk of developing drug resistance, cross-resistance and AEs.
Optimizing decision-making potential, cost, and environmental impact of traps for monitoring olive fruit fly Bactrocera oleae (Rossi) (Diptera: Tephritidae)
Authors: Moreno-Alcaide Flora , Quesada-Moraga Enrique , Valverde-García Pablo , Yousef-Yousef Meelad 
Published: January 2025

Abstract
This work aimed to optimize olive fruit fly (OFF) Bactrocera oleae (Rossi) (Diptera: Tephritidae) monitoring and integrated management, thereby ensuring optimal and less-costly decision-making and timely intervention. Field trials in Andalusia (Spain) were undertaken over 2 years to optimize trap model, color, size, and density for the accurate determination of pest spatial distribution and damage as a function of olive cultivar. McPhail traps and yellow sticky panels outperformed the other 4 models with respect to the number of OFF captured. However, McPhail traps caught more natural enemies than yellow sticky panels and so sticky panels were selected to unravel the effect of color on the number of both OFF and natural enemies [hymenopteran parasitoids (Psyttalia concolor) and lacewings (Chrysopidae)] captured. Yellow sticky panels outperformed white, green, and blue ones for the number of OFF captured and captured the fewest natural enemies. When comparing the surface area of yellow sticky panels, 20 × 25 and 10 × 25 cm double-sided panels were equally effective at catching OFF. However, large double-sided yellow sticky panels caught significantly more natural enemies than the small double-sided panels, a key result for developing a less costly and environmentally friendly monitoring system. Furthermore, it was shown that the damage curve had a cultivar-based shape, i.e., for the same population size of OFF the damage caused varied depending on cultivar. Finally, 15 sticky panels per hectare were the optimal number for estimation of OFF spatial distribution. The present research provides key information for new trap design, OFF forecasting, and IPM development.
Establishing best practices for insect resistance management: a new paradigm for genetically engineered toxins in cotton expressing Mpp51Aa2
Authors: Reisig Dominic , Huseth Anders 
Published: January 2025

Abstract
Debate over resistance management tactics for genetically engineered (GE) crops expressing insecticidal toxins is not new. For several decades, researchers, regulators, and agricultural industry scientists have developed strategies to limit the evolution of resistance in populations of lepidopteran and coleopteran pests. A key attribute of many of these events was insecticide resistance management (IRM) strategies designed around a presumed high-dose expression sufficient to kill 99.5% of exposed larvae for some of the main target pests in corn, Zea mays L. and cotton, Gossypium hirsutum L. In contrast, other target pests did not meet this high-dose criterion. Similarly, the recent release of ThryvOn cotton that expresses thysanopteran and hemipteran active Mpp51Aa2.834_16 toxin is not high dose, working on a combination of behavioral and sublethal effects to suppress populations. This unique mode of control has generated considerable uncertainty about what IRM strategies will be most effective to limit field-evolved resistance to this unique spectrum of pests. The goal of this manuscript is to present several knowledge gaps that exist in proposed Mpp51Aa2 IRM plans, focusing on its activity on thrips, Frankliniella spp. Addressing these gaps will be crucial to limit resistance and preserve the benefits that this technology may provide by alleviating reliance on conventional insecticides and seed treatments. Broadly, these considerations will be important for future GE events that are non-high dose but remain valuable components of a more holistic insect management programs that integrate multiple tactics to reduce conventional insecticide use for challenging pests.
Development and reproduction of Grapholita molesta (Lepidoptera: Tortricidae) on the 3 artificial diets in the laboratory
Authors: Sun Xiaoting , Ge Shishuai , Chu Bo , He Wei , Yang Xianming , Wu Kongming 
Published: January 2025

Abstract
Grapholita molesta (Busck) (Lepidoptera: Tortricidae) is a major pest of many fruit trees. The large-scale artificial propagation technology of the insect is the basis for the field application of the sterile insect technique and biological control products based on host mass reproduction. However, a low-cost diet with easily accessible materials remains lacking. In this study, we assessed the insect rearing performance feeding on 3 artificial diets: D1: an artificial diet based on wheat bran and soybean powders; D2: an artificial diet based on soybean powder, maize powders, and tomato sauce; and D3: an artificial diet based on soybean powder, maize powder, tomato sauce, and wheat bran, with apples as a control, using 2-sex life table. At 26 ± 1 °C, 70 ± 5% humidity, and 16:8 h L:D photoperiod, the biological indicators of G. molesta fed D1 were consistent with those fed apples, with a larval stage of 14.88 d, a pupal stage of 7.57 d, adult longevity of 22.69 d, egg deposition count of 223.22, intrinsic rate of increase (r) of 0.1359, finite rate of increase (λ) of 1.1456, and net reproductive rate (R0) of 94.50. D1 was used to continuously rear G. molesta population for 5 generations, all life parameters remained normal. These results indicated that the artificial diet based on wheat bran and soybean powder could be used for rearing of the insect. This study proposes an available and cost-effective artificial diet for G. molesta, facilitating the application of green prevention and control technology.
Heterogeneity in Household Inflation Expectations and Monetary Policy
Authors: Doh Taeyoung , Lee Ji Hyung , Park Woong Yong 
Published: January 2025

Abstract
We empirically characterize the heterogeneity in the conditional distribution of household inflation expectations across demographic groups using the Survey of Consumer Expectations and also investigate how monetary policy shocks affect the conditional distribution. We find that, across all the groups, the peak of the group-specific distribution of household inflation expectations aligns closely with the 2% target set by the Federal Reserve, but there is substantial heterogeneity both within and across groups, primarily on the right. However, in response to a contractionary monetary policy shock identified by high-frequency financial market responses, households overall adjust their inflation expectations significantly downwards. In addition, the magnitude of the reaction is more pronounced in the upper quantile of low-income groups whose unconditional inflation expectations are less well anchored.
Acupuncture gone awry: surgical management of a popliteal artery pseudoaneurysm with concurrent abdominal aortic aneurysm
Authors: Asteguieta Sebastian , Diaz Q Carlos , Jacobs Luis P , Villeda Kelly , Estrada Sebastian 
Published: January 2025

Abstract
Popliteal artery pseudoaneurysms are rare, especially from acupuncture-related trauma. We report a 67-year-old male with hypertension, diabetes, chronic kidney disease, and an abdominal aortic aneurysm (AAA), who developed a popliteal pseudoaneurysm after acupuncture. Imaging confirmed the pseudoaneurysm and a 55 mm AAA. Urgent surgical repair with a Gore-Tex graft led to a smooth recovery. This case emphasizes the vascular risks of acupuncture and the importance of early diagnosis, multidisciplinary care, and personalized follow-up in patients with complex comorbidities.
Chronology of transcriptome and proteome expression during early Arabidopsis flower development
Authors: Álvarez-Urdiola Raquel , Matus José Tomás , González-Miguel Víctor Manuel , Bernardo-Faura Martí , Riechmann José Luis 
Published: January 2025

Abstract
The complex gene regulatory landscape underlying early flower development in Arabidopsis has been extensively studied through transcriptome profiling, and gene networks controlling floral organ development have been derived from the analyses of genome-wide binding of key transcription factors. In contrast, the dynamic nature of the proteome during the flower development process is much less understood. In this study, we characterized the floral proteome at different stages during early flower development and correlated it with unbiased transcript expression data. Shotgun proteomics and transcript profiling were conducted using an APETALA1 (AP1)-based floral induction system. A specific analysis pipeline to process the time-course proteomics data was developed. In total, 8924 proteins and 23 069 transcripts were identified. Co-expression analysis revealed that RNA–protein pairs clustered in various expression pattern modules. An overall positive correlation between RNA and protein level changes was observed, but subgroups of RNA–protein pairs with anti-correlated gene expression changes were also identified and found to be enriched in hormone-responsive pathways. In addition, the RNA-seq dataset reported here further expanded the identification of genes whose expression changes during early flower development, and its combination with previously published AP1 ChIP-seq datasets allowed the identification of additional direct and high-confidence targets of AP1.
Identification of a gene controlling levels of the copper response regulator 1 transcription factor in Chlamydomonas reinhardtii
Authors: Sun Xiaoqing , LaVoie Matthew , Lefebvre Paul A , Gallaher Sean D , Glaesener Anne G , Strenkert Daniela , Mehta Radhika , Merchant Sabeeha S , Silflow Carolyn D 
Published: January 2025

Abstract
Oxygen prevents hydrogen production in Chlamydomonas (Chlamydomonas reinhardtii), in part by inhibiting the transcription of hydrogenase genes. We developed a screen for mutants showing constitutive accumulation of iron hydrogenase 1 (HYDA1) transcripts in normoxia. A reporter gene required for ciliary motility placed under the control of the HYDA1 promoter conferred motility only in hypoxia. By selecting for mutants able to swim even in normoxia, we obtained strains that constitutively express the reporter gene. One identified mutant was affected in a gene encoding an F-box protein 3 (FBXO3) that participates in ubiquitylation and proteasomal degradation pathways in other eukaryotes. Transcriptome profiles revealed that the mutation, termed cehc1-1 (constitutive expression of hydrogenases and copper-responsive genes), triggers the upregulation of genes known to be targets of copper response regulator 1 (CRR1), a transcription factor involved in the nutritional copper signaling pathway and in the hypoxia response pathway. CRR1 was required for upregulating the HYDA1 reporter gene expression in response to hypoxia and for the constitutive expression of the reporter gene in cehc1-1 mutant cells. The CRR1 protein, normally degraded in Cu-supplemented cells, was stabilized in cehc1-1 cells, supporting the conclusion that CEHC1 facilitates CRR1 degradation. Our results describe a previously unknown pathway for CRR1 inhibition and possibly other pathways leading to complex metabolic changes.
The effect of conditional incentives in an email–web valuation survey of recreational anglers
Authors: Carter David W , Lovell Sabrina , Records David , Liese Christopher 
Published: January 2025

Abstract
Web surveys often suffer from low response rates when invitations are sent via email. We conducted an experiment testing the effects of a $5 Starbucks gift card incentive on response rates and survey results from an email–web survey of Gulf of Mexico recreational anglers. Half the sample was randomly assigned to be offered the incentive for completion of the survey. Despite this, response rates were nearly identical between the incentivized (12 percent) and non-incentivized (13 percent) groups. Respondent demographics, fishing trip characteristics, and econometric estimates were highly consistent across groups. Statistical tests could not reject the null of no difference between the incentive treatments. Our results suggest foregoing small conditional non-monetary incentives can be cost-effective for this type of specialized recreation survey using an email protocol. However, generalizability to other populations, incentives, and protocols requires further research. The non-monetary incentive did not meaningfully impact response rates or estimates in this context.
The Possible effect of Bosentan on the methotrexate-induced salivary gland changes in male rats: histological and Immunohistochemical study
Authors: Attarbashee Rana Khairi , Hamodat Heba Faiz , Mammdoh Jawnaa Khalid , Ridha-Salman Hayder 
Published: January 2025

Abstract
Methotrexate (MTX) is an antimetabolite drug utilized for managing a variety of cancers and autoinflammatory conditions. MTX may trigger detrimental effects in mout, h tissues, including salivary gland impairment. Bosentan (BOS), a drug that blocks endothelin receptors, has strengthened antioxidant, anti-inflammatory, and anti-apoptotic properties. The study aimed to estimate the protective effect of BOS on MTX-exacerbated salivary changes in Wistar Albino rats. Thirty male rats were arbitrarily sorted into three groups of ten animals each. The control group received a normal saline for 18 days. The MTX (induction) group received MTX (25 mg/kg) intraperitoneally on the 7th day of the experiment once daily for 6 consecutive days. The MTX + BOS group received BOS (50 mg/kg) orally once a day for 18 days: 6 days before induction, 6 days 2-h after induction, and 6 days post-induction. Animals were euthanized on day 19, and salivary gland tissues were dissected for biochemical, histopathological, and immunohistochemical analyses. BOS dramatically improved MTX-aggravated biochemical and histopathological abnormalities, as evidenced by diminished Bax, caspase 3, TNF-α, IL-1β, MDA, and MPO levels, increased SOD, GSH, and GPX levels, and reduced degenerative changes in the granular convolute tubule, mucous acini, and striate duct. BOS further substantially upregulated MTX-induced decline of the Ki-67 and Bcl-2, as indicated by immunohistochemistry scoring methods. The anti-oxidative, ant-inflammatory, and antiapoptotic properties of BOS are a promising strategy for ameliorating the toxic effect of MTX on submandibular glandular tissues.
A Supervised Home-Based Exercise Program to Improve Functional Performance in Women With Breast Cancer (Home-Pac): A Randomized Controlled Trial
Authors: Ramos Pedro G.F. , Júdice Pedro B. , Valadas Gabriela , Bento Alexandra , Nobre Inês , Rodrigues Bruno , Carraça Eliana V. 
Published: January 2025

Background:
Endocrine therapy’s effects may hinder the functional performance and quality of life of women with breast cancer. Physical activity can counteract these effects, but this population does not regularly adopt it. This study aimed to test the impact of a 12-week home-based exercise intervention with a supervised component on the functional performance, quality of life, and physical activity of women with breast cancer undergoing endocrine therapy.

Methods:
Twenty-one women were initially randomized. Three participants were missing at random before the intervention started, leaving 18 with breast cancer stage I to III diagnosis, aged 18 to 75 years, receiving endocrine therapy, and reporting low to moderate activity levels. The study comprised a weekly online exercise session and, an exercise booklet intervention, and control group. Functional performance, quality of life, and physical activity were assessed. ANOVAs with repeated measures and Bonferroni-adjusted pairwise comparisons were conducted.

Results:
High adherence to program was observed (80%). Significant group-by-time interactions, favoring the intervention group, were found for functional performance—sit-to-stand (F = 19.64; P < .001; Eta2 = .55), arm curl (F = 13.01; P = .002; Eta2 = .45), and timed-up-go (F = 12.22; P = .003; Eta2 = .43); quality of life—insomnia (F = 6.05; P = 0.026; Eta2 = .27) and global health status (F = 6.81; P = .020; Eta2 = .31); and total physical activity (F = 5.95; P = .027; Eta2 = .27).

Conclusion:
The findings suggest that home-based exercise programs might be feasible and improve strength and overall mobility. These programs may contribute to increasing physical activity and quality of life of women with breast cancer. Further studies with larger samples are needed to confirm these findings.
Understanding the rising abuse of veterinary medicine xylazine: a review
Authors: Ikram Areeba , Ikram Sameen , Zainab Asra , Inam Mubah , Azhar Ayesha , Elsayed Saeed Ahmed Saleh 
Published: January 2025

Xylazine, the new “zombie drug” is a veterinary medicine utilized for anesthesia, sedation, muscle relaxation and pain relief, to facilitate the approach of medical examinations, X rays, minor superficial surgeries, and any other painful manipulative procedure across a variety of species. Xylazine use as an adulterant among other drugs of abuse like heroin and fentanyl was first reported in Puerto Rico in 2006. Over time it has made its way to illicit drug trades, implicated in xylazine-positive overdose deaths. It acts as an ‘Alpha 2 Adrenergic Agonist’ and accelerates the activation of ‘inhibitory neurons’ in CNS. Owing to its inhibitory effects, prolonged duration of action and easy accessibility, xylazine serves widely as a recreational drug. Its long-drawn abuse aggravates toxic effects including hypotension, necrotic skin lesion, respiratory and CNS depression and cardiac arrest.
Xylazine, a veterinary tranquilizer, not approved for human use by the FDA has emerged as a new drug of abuse on the streets. Multiple studies suggest a high rise in xylazine associated overdose deaths especially in the United States due to its endemic region of Puerto Rico, where it is widely and easily available. FDA has issued a high alert highlighting rise in “zombie drug” abuse. Awareness of xylazine and its fatal outcomes among public is of immense importance in preventing its abuse.
Technological innovation and revolution with single-use digital flexible ureteroscopes: a review from section of EAU Endourology
Authors: Talyshinskii Ali , Tzelves Lazaros , Ventimiglia Eugenio , Yuen Steffi Kar Kai , Gauhar Vineet , Traxer Oliver , Somani Bhaskar 
Published: January 2025

Purpose of review
Numerous scope-related innovations have taken place in the field of endourology. The presented analytical review is aimed at studying the technical innovations of the single-use digital flexible ureteroscopes. In November 2024, a comprehensive search was done for information on latest disposable flexible digital ureteroscopes, as well as their various unique characteristics. A thorough examination was conducted for image qualities; sizes and channels; and deflection capabilities. Furthermore, supplementary features about the latest advances were assigned to a separate group including ‘Unique’ solutions. Using the last search query, various innovations in flexible ureteroscopy in general were also searched and sorted into appropriate groups.

Recent findings
Modern single-use flexible digital ureteroscopes are characterized by advanced technologies for transmitting light and images, miniaturization, as well as by a number of unique solutions that were previously characteristic only of semi-rigid or fiberoptic endoscopes. These include features such as integrated buttons for data recording, self-locking mechanism, separate ports, rotating shaft, direct-in-scope suction, pressure monitoring, enhanced tip control and customizable settings.

Summary
Since their introduction in urology, endoscopes have undergone many changes, as illustrated by the example of single-use flexible digital ureteroscopes. The imaging quality has improved, the dimensions of both the distal tip and shaft have decreased, with over 15 manufactures producing and distributing these scopes. A lot of new additional new features are likely to enhance the efficacy and safety of ureteroscopic procedures.