bluuebunny/crossref_metadata_2025_split huggingface dataset:
A qualitative study on stress, coping strategies and feasibility of music intervention among women with cancer receiving chemotherapy during COVID-19 pandemic in Vietnam
Authors: Nguyen Khanh T. , Vu Nhung T. H. , Tran Mai T. T. , Chan Carmen W. H. 
Published: January 2023

AbstractBreast and gynaecological cancer (BGC) patients receiving chemotherapy may experience high levels of stress during the COVID-19 pandemic. Music interventions may be effective in lowering their stress levels. This study explored stressors, coping strategies, and the feasibility of music interventions among BGC patients in Vietnam. An exploratory qualitative study with individual face-to-face semi-structured interviews was conducted. A convenience sample of BGC patients receiving chemotherapy was recruited from the oncology centre of a public hospital in Vietnam. Twenty patients were interviewed with open-ended questions developed based on the transactional model of stress and coping to explore stress-causing factors and coping strategies and based on guidelines for music therapy practice to explore their music preferences and perceptions. Field notes and interview transcripts were analysed following the qualitative content analysis approach. Two stressor themes were identified: undesirable experiences during treatment and patients’ inability to fulfil their own roles and responsibilities. Our findings revealed a new coping strategy—self-realisation of responsibilities towards the family—that is not listed in the transactional model of stress and coping. Future psychological interventions for stress management among BGC patients should focus on raising the patients’ awareness of their values and responsibilities towards their families. Three categories of preferred music genres for stress reduction were identified: religious, softly melodic, and revolutionary music. The patients were aware of the positive effects of music and had different musical preferences. This study also explored the acceptance of music interventions and facilitators and barriers to implementing them among BGC patients in Vietnam. The findings suggest that before implementing music interventions, the musical preferences, religions, and beliefs of each individual should be considered to achieve desirable results. Music interventions for BGC patients receiving chemotherapy in Vietnam are feasible. Further intervention studies are needed to evaluate their effectiveness.
CT-radiomics and clinical risk scores for response and overall survival prognostication in TACE HCC patients
Authors: Bernatz Simon , Elenberger Oleg , Ackermann Jörg , Lenga Lukas , Martin Simon S. , Scholtz Jan-Erik , Koch Vitali , Grünewald Leon D. , Herrmann Yannis , Kinzler Maximilian N. , Stehle Angelika , Koch Ina , Zeuzem Stefan , Bankov Katrin , Doering Claudia , Reis Henning , Flinner Nadine , Schulze Falko , Wild Peter J. , Hammerstingl Renate , Eichler Katrin , Gruber-Rouh Tatjana , Vogl Thomas J. , dos Santos Daniel Pinto , Mahmoudi Scherwin 
Published: January 2023

AbstractWe aimed to identify hepatocellular carcinoma (HCC) patients who will respond to repetitive transarterial chemoembolization (TACE) to improve the treatment algorithm. Retrospectively, 61 patients (mean age, 65.3 years ± 10.0 [SD]; 49 men) with 94 HCC mRECIST target-lesions who had three consecutive TACE between 01/2012 and 01/2020 were included. Robust and non-redundant radiomics features were extracted from the 24 h post-embolization CT. Five different clinical TACE-scores were assessed. Seven different feature selection methods and machine learning models were used. Radiomics, clinical and combined models were built to predict response to TACE on a lesion-wise and patient-wise level as well as its impact on overall-survival prognostication. 29 target-lesions of 19 patients were evaluated in the test set. Response rates were 37.9% (11/29) on the lesion-level and 42.1% (8/19) on the patient-level. Radiomics top lesion-wise response prognostications was AUC 0.55–0.67. Clinical scores revealed top AUCs of 0.65–0.69. The best working model combined the radiomic feature LargeDependenceHighGrayLevelEmphasis and the clinical score mHAP_II_score_group with AUC = 0.70, accuracy = 0.72. We transferred this model on a patient-level to achieve AUC = 0.62, CI = 0.41–0.83. The two radiomics-clinical features revealed overall-survival prognostication of C-index = 0.67. In conclusion, a random forest model using the radiomic feature LargeDependenceHighGrayLevelEmphasis and the clinical mHAP-II-score-group seems promising for TACE response prognostication.
Photo-plasmonic effect as the hot electron generation mechanism
Authors: Akbari-Moghanjoughi M. 
Published: January 2023

AbstractBased on the effective Schrödinger–Poisson model a new physical mechanism for resonant hot-electron generation at irradiated half-space metal–vacuum interface of electron gas with arbitrary degree of degeneracy is proposed. The energy dispersion of undamped plasmons in the coupled Hermitian Schrödinger–Poisson system reveals an exceptional point coinciding the minimum energy of plasmon conduction band. Existence of such exceptional behavior is a well-know character of damped oscillation which in this case refers to resonant wave–particle interactions analogous to the collisionless Landau damping effect. The damped Schrödinger–Poisson system is used to model the collective electron tunneling into the vacuum. The damped plasmon energy dispersion is shown to have a full-featured exceptional point structure with variety of interesting technological applications. In the band gap of the damped collective excitation,depending on the tunneling parameter value, there is a resonant energy orbital for which the wave-like growing of collective excitations cancels the damping of the single electron tunneling wavefunction. This important feature is solely due to dual-tone wave-particle oscillations, characteristics of the collective excitations in the quantum electron system leading to a resonant photo-plasmonic effect, as a collective analog of the well-known photo-electric effect. The few nanometer wavelengths high-energy collective photo-electrons emanating from the metallic surfaces can lead to a much higher efficiency of plasmonic solar cell devices, as compared to their semiconductor counterpart of electron–hole excitations at the Fermi energy level. The photo-plasmonic effect may also be used to study the quantum electron tunneling and electron spill-out at metallic surfaces. Current findings may help to design more efficient spasers by using the feature-rich plasmonic exceptional point structure.
Auxin supplementation under nitrogen limitation enhanced oleic acid and MUFA content in Eustigmatos calaminaris biomass with potential for biodiesel production
Authors: Krzemińska Izabela , Szymańska Marlena , Ciempiel Wioleta , Piasecka Agata 
Published: January 2023

AbstractDue to their lipid accumulation potential, microalgae are widely studied in terms of their use in the production of biodiesel. The present study was focused on determination of changes in the biomass production, biochemical composition, accumulation and distribution of fatty acids in neutral lipids, glycolipids, phospholipids and biodiesel properties of soil microalga Eustigmatos calaminaris in response to various levels of nitrogen stress and indole-3-acetic acid supplementation. The highest growth rate, the highest lipid content and daily lipid productivity were noted at the nitrogen limitation up to 25% with IAA supplementation. The increase in NL was associated with nutrient stress. An increase in the level of GL and PL were recorded upon the reduction of the nitrogen content (25% N) and the addition of IAA. The gas chromatography/mass spectrometry analysis demonstrated that C16:0, C16:1, and C18:1 were the main fatty acids in E. calaminaris lipids. As shown by the lipidomic analysis, the IAA supplementation in the nitrogen limitation variants enhanced the content of TAGs in C18:1 and monounsaturated fatty acids. The current findings indicated a potential strategy to improve the fatty acid profile in neutral lipids and high potential of E. calaminaris for biodiesel applications.
Synthesis of superhydrophobic coatings based on silica nanostructure modified with organosilane compounds by sol–gel method for glass surfaces
Authors: Ghodrati Mohammad , Mousavi-Kamazani Mehdi , Bahrami Zohreh 
Published: January 2023

AbstractIn the present study, the superhydrophobic coating was synthesized by spherical silica nanostructures modified with organosilane compounds for glass surfaces. To optimize the conditions in terms of cost-effectiveness and create a super-hydrophobic coating with a high contact angle, the response surface method of the central composite design (CCD) model was performed for the StÖber method, and the contact angle was defined as the response surface for the model. Tetraethoxysilane (TEOS) was used as a precursor and poly(dimethylsiloxane) (PDMS) was used to modify the surface of a spherical silica nanostructure synthesized by a one-step sol–gel method using a base catalyst. The accuracy of the research was checked by the contact angle measurement test and an angle of 162° was obtained. XRD, FT-IR, EDS, SEM, DLS, and AFM analyzes were performed to investigate the synthesis of silica nanostructure. Chemical resistance was performed in acidic, neutral, and alkaline environments and the contact angles were 127°, 134°, and 90°, respectively, which indicates that the coating created on the surface glass has good chemical resistance in acidic and neutral environments.
Modeling and affinity maturation of an anti-CD20 nanobody: a comprehensive in-silico investigation
Authors: Poustforoosh Alireza , Faramarz Sanaz , Negahdaripour Manica , Hashemipour Hassan 
Published: January 2023

AbstractB-cell Non-Hodgkin lymphomas are the malignancies of lymphocytes. CD20 is a membrane protein, which is highly expressed on the cell surface of the B-cells in NHL. Treatments using monoclonal antibodies (mAbs) have resulted in failure in some cases. Nanobodies (NBs), single-domain antibodies with low molecular weights and a high specificity in antigen recognition, could be practical alternatives for traditional mAbs with superior characteristics. To design an optimized NB as a candidate CD20 inhibitor with raised binding affinity to CD20, the structure of anti-CD20 NB was optimized to selectively target CD20. The 3D structure of the NB was constructed based on the optimal templates (6C5W and 5JQH), and the key residues were determined by applying a molecular docking study. After identifying the key residues, some mutations were introduced using a rational protocol to improve the binding affinity of the NB to CD20. The rational mutations were conducted using the experimental design (Taguchi method). Six residues (Ser27, Thr28, Phe29, Ile31, Asp99, and Asn100) were selected as the key residues, and five residues were targeted for rational mutation (Trp, Phe, His, Asp, and Tyr). Based on the mutations suggested by the experimental design, two optimized NB structures were constructed. NB2 showed a remarkable binding affinity to CD20 in docking studies with a binding energy of − 853 kcal/mol. The optimized NB was further evaluated using molecular dynamics simulation. The results revealed that CDR1 (complementarity determining regions1) and CDR3 are essential loops for recognizing the antigen. NB2 could be considered as a potential inhibitor of CD20, though experimental evaluations are needed to confirm it.
Antibody-drug conjugates in lung cancer: dawn of a new era?
Authors: Coleman Niamh , Yap Timothy A. , Heymach John V. , Meric-Bernstam Funda , Le Xiuning 
Published: January 2023

AbstractAntibody-drug conjugates (ADCs) are one of fastest growing classes of oncology drugs in modern drug development. By harnessing the powers of both cytotoxic chemotherapy and targeted therapy, ADCs are unique in offering the potential to deliver highly potent cytotoxic agents to cancer cells which express a pre-defined cell surface target. In lung cancer, the treatment paradigm has shifted dramatically in recent years, and now ADCs are now joining the list as potential options for lung cancer patients. Since 2020, the first ADC for NSCLC patients has been FDA-approved (trastuzumab deruxtecan) and two ADCs have been granted FDA Breakthrough Therapy Designation, currently under evaluation (patritumab deruxtecan, telisotuzumab vedotin). Furthermore, several early-phase trials are assessing various novel ADCs, either as monotherapy or in combinations with advanced lung cancer, and more selective and potent ADCs are expected to become therapeutic options in clinic soon. In this review, we discuss the structure and mechanism of action of ADCs, including insights from pre-clinical work; we summarize the ADCs’ recent progress in lung cancer, describe toxicity profiles of ADCs, and explore strategies designed to enhance ADC potency and overcome resistance. In addition, we discuss novel ADC strategies of interest in lung cancer, including non-cytotoxic payloads, such as immunomodulatory and anti-apoptotic agents.
Effectiveness of gamified team competition as mHealth intervention for medical interns: a cluster micro-randomized trial
Authors: Wang Jitao , Fang Yu , Frank Elena , Walton Maureen A. , Burmeister Margit , Tewari Ambuj , Dempsey Walter , NeCamp Timothy , Sen Srijan , Wu Zhenke 
Published: January 2023

AbstractGamification, the application of gaming elements to increase enjoyment and engagement, has the potential to improve the effectiveness of digital health interventions, while the effectiveness of competition gamification components remains poorly understood on residency. To address this gap, we evaluate the effect of smartphone-based gamified team competition intervention on daily step count and sleep duration via a micro-randomized trial on medical interns. Our aim is to assess potential improvements in the factors (namely step count and sleep) that may help interns cope with stress and improve well-being. In 1779 interns, team competition intervention significantly increases the mean daily step count by 105.8 steps (SE 35.8, p = 0.03) relative to the no competition arm, while does not significantly affect the mean daily sleep minutes (p = 0.76). Moderator analyses indicate that the causal effects of competition on daily step count and sleep minutes decreased by 14.5 steps (SE 10.2, p = 0.16) and 1.9 minutes (SE 0.6, p = 0.003) for each additional week-in-study, respectively. Intra-institutional competition negatively moderates the causal effect of competition upon daily step count by −90.3 steps (SE 86.5, p = 0.30). Our results show that gamified team competition delivered via mobile app significantly increases daily physical activity which suggests that team competition can function as a mobile health intervention tool to increase short-term physical activity levels for medical interns. Future improvements in strategies of forming competition opponents and introducing occasional competition breaks may improve the overall effectiveness.
DNA uptake from a laboratory environment drives unexpected adaptation of a thermophile to a minor medium component
Authors: Zeldes Benjamin , Poehlein Anja , Jain Surbhi , Baum Christoph , Daniel Rolf , Müller Volker , Basen Mirko 
Published: January 2023

Abstract
DNA uptake is widespread among microorganisms and considered a strategy for rapid adaptation to new conditions. While both DNA uptake and adaptation are referred to in the context of natural environments, they are often studied in laboratories under defined conditions. For example, a strain of the thermophile Thermoanaerobacter kivui had been adapted to growth on high concentrations of carbon monoxide (CO). Unusual phenotypes of the CO-adapted strain prompted us to examine it more closely, revealing a horizontal gene transfer (HGT) event from another thermophile, Thermoanaerobacter sp. strain X514, being cultured in the same laboratory. The transferred genes conferred on T. kivui the ability to utilize trehalose, a trace component of the yeast-extract added to the media during CO-adaptation. This same HGT event simultaneously deleted a native operon for thiamine biosynthesis, which likely explains why the CO-adapted strain grows poorly without added vitamins. Attempts to replicate this HGT by providing T. kivui with genomic DNA from Thermoanaerobacter sp. strain X514 revealed that it is easily reproducible in the lab. This subtle form of “genome contamination” is difficult to detect, since the genome remains predominantly T. kivui, and no living cells from the original contamination remain. Unexpected HGT between two microorganisms as well as simultaneous adaptation to several conditions may occur often and unrecognized in laboratory environments, requiring caution and careful monitoring of phenotype and genotype of microorganisms that are naturally-competent for DNA uptake.
Impact of nanoparticles on amyloid β-induced Alzheimer’s disease, tuberculosis, leprosy and cancer: a systematic review
Authors: Chakraborty Ayon , Mohapatra Saswati Soumya , Barik Subhashree , Roy Ipsita , Gupta Bhavika , Biswas Ashis 
Published: January 2023

Abstract
Nanotechnology is an interdisciplinary domain of science, technology and engineering that deals with nano-sized materials/particles. Usually, the size of nanoparticles lies between 1 and 100 nm. Due to their small size and large surface area-to-volume ratio, nanoparticles exhibit high reactivity, greater stability and adsorption capacity. These important physicochemical properties attract scientific community to utilize them in biomedical field. Various types of nanoparticles (inorganic and organic) have broad applications in medical field ranging from imaging to gene therapy. These are also effective drug carriers. In recent times, nanoparticles are utilized to circumvent different treatment limitations. For example, the ability of nanoparticles to cross the blood−brain barrier and having a certain degree of specificity towards amyloid deposits makes themselves important candidates for the treatment of Alzheimer’s disease. Furthermore, nanotechnology has been used extensively to overcome several pertinent issues like drug-resistance phenomenon, side effects of conventional drugs and targeted drug delivery issue in leprosy, tuberculosis and cancer. Thus, in this review, the application of different nanoparticles for the treatment of these four important diseases (Alzheimer’s disease, tuberculosis, leprosy and cancer) as well as for the effective delivery of drugs used in these diseases has been presented systematically. Although nanoformulations have many advantages over traditional therapeutics for treating these diseases, nanotoxicity is a major concern that has been discussed subsequently. Lastly, we have presented the promising future prospective of nanoparticles as alternative therapeutics. In that section, we have discussed about the futuristic approach(es) that could provide promising candidate(s) for the treatment of these four diseases.
Healing From Home: Examination of an Online Mindfulness-Based Tinnitus Stress Reduction Course During the 2020 COVID Pandemic
Authors: Gans Jennifer J. , Holst Jennifer , Holmes Corrie , Hudock Daniel 
Published: January 2023

Purpose:
The purpose of this study was to assess the effectiveness of an Internet delivered Mindfulness Based Tinnitus Stress Reduction (i-MBTSR) program during the COVID-19 pandemic. Tinnitus, often a chronic condition, is experienced by 15% of the population. For those with severe, bothersome tinnitus, quality of life is reduced and the treatment options are limited. We evaluated an approach intended to decrease tinnitus-related distress.

Method:
This study examined the data collected for an online i-MBTSR course using a retrospective design. The intervention included an 8-week self-paced i-MBTSR course, including didactic information about mindfulness and tinnitus, as well as meditation practices. Outcome measures included the Tinnitus Functional Index (TFI) and Perceived Stress Scale (PSS), which were measured at four time periods. These time points included pretreatment, midtreatment at 3 weeks, immediately posttreatment, and at 6-month follow-up.

Results:

Forty-three participants completed the intervention. The mean preintervention tinnitus severity rating was 59.96 (“severe tinnitus”) as measured by the TFI. Mean TFI scores dropped to 44.16 (
p
< .001) at midtreatment and to 34.23 (
p
= .001) at posttreatment. Repeated-measures analysis of variance and multivariate analysis of variance tests were conducted to determine changes in the two scales at the four time periods. There were significant differences in perceived stress and tinnitus self-function found in all measures and submeasures between the pre-, mid-, and posttreatment time points with the exception of the TFI Auditory subtest. These gains remained significant for those who completed the 6-month follow-up.

Conclusions:
The i-MBTSR course appears to be a viable and effective treatment modality. A shorter 3-week course may be effective. Case-control studies to more systematically investigate the effectiveness of i-MBTSR for tinnitus are required.
Self-Reported Communication Attitudes of Children With Childhood Apraxia of Speech: An Exploratory Study
Authors: Keller Sydney , Maas Edwin 
Published: January 2023

Purpose:
Much of the research literature on childhood apraxia of speech (CAS) has focused on understanding, diagnosing, and treating the impairment, rather than examining its functional effect on children's daily lives. This study focuses on the Personal Factors component of the World Health Organization International Classification of Functioning, Disability and Health–Children and Youth Version Framework. Specifically, the purpose was to examine the self-reported communication attitudes of children with CAS.

Method:
Two validated communication attitude questionnaires were administered to 12 children with CAS enrolled in an intensive speech-focused intervention (age range: 4–10 years old). Children's scores were compared to the questionnaires' typically developing norms. Descriptive analyses explored relationships between communication attitude and CAS severity, caregiver perceptions of communicative participation, frustration ratings during therapy, and change in communication attitude over a brief time.

Results:
Older (ages 6–10 years) but not younger (ages 4–5;11 [years;months]) children with CAS were more likely to have negative attitudes about their speech. No clear relationships were observed between communication attitudes and caregiver perceptions of communicative participation; small positive relationships were observed between communication attitude and frustration during therapy. For the younger children, there was also a relationship with CAS severity. For most children, no change in communication attitude was observed over a brief period, though one child appeared to develop more negative and one appeared to develop more positive attitudes.

Conclusions:
These initial findings suggest that older children with CAS may be at greater risk for negative communication attitudes than their peers without CAS. The findings also highlight the need to include more child self-report measures in research. Further implications for CAS assessment and intervention are discussed.

Supplemental Material:

https://doi.org/10.23641/asha.21834432