bluuebunny/crossref_metadata_2025_split huggingface dataset:
Wireless and Flexible Tactile Sensing Array Based on an Adjustable Resonator with Machine‐Learning Perception
Authors: Xu Baochun , Chen Da , Wang Yu , Tang Ruili , Yang Lina , Feng Hui , Liu Yijian , Wang Zhuopeng , Wang Fei , Zhang Tong 
Published: April 2023

AbstractIntelligent soft robotics and wearable electronics require flexible, wireless radio frequency (RF) pressure sensors for human‐like tactile perception of their moving parts. Existing devices face two challenges for array extension: the construction of sensitive units over a limited area and the handling of resonant peaks overlapping within the channel width. Herein, a simply adjustable RF‐resonator‐based tactile array (RFTA) is reported, in which the initial frequency of each resonator unit is regulated by doping polydimethylsiloxane (PDMS) dielectric layers with various concentrations of multiwalled carbon nanotubes (MWCNTs). An array is constructed using four sensor units with a frequency interval of 15 MHz and a multi‐layer micropyramid structure is employed to obtain a low detection limit (<1 Pa) and high sensitivity (17.49 MHz kPa‐1 in the low‐pressure range). A machine‐learning‐based strategy identifies tactile positions precisely via a one‐time S11 reading, achieving 98.5% accuracy with six stimulation modes. Furthermore, the RFTA distinguishes six objects during the grasping process when installed on a soft manipulator. The device shows considerable potential to be extended for flexible moving scenarios and high‐integrated tactile sensing systems for soft robotics.
Uncovering the Different Components of Contact Resistance to Atomically Thin Semiconductors
Authors: Ber Emanuel , Grady Ryan W. , Pop Eric , Yalon Eilam 
Published: April 2023

AbstractAchieving good electrical contacts is one of the major challenges in realizing devices based on atomically thin 2D semiconductors. Several studies have examined this hurdle, but a universal understanding of the contact resistance (Rc) and an underlying approach to its reduction are currently lacking. Here, the classical Rc transmission line model description of contacts to 2D materials is experimentally examined, and a modification based on an additional lateral resistance component, namely, the junction resistance (Rjun) is offered. A combination of transfer length method and contact‐end measurements to characterize contacts to monolayer MoS2 and separate the different Rc components is used. Technology computer‐aided design simulations are also used to study Rc in Fermi‐level pinned and unpinned contacts. This study finds that Rjun is the dominating component of Rc in atomically thin semiconductor devices, and is also responsible for most of the back‐gate bias and temperature dependence. The experimental results help understand the underlying physics of state‐of‐the‐art contact engineering in the context of minimizing Rjun.
Coming to the Caribbean—acclimation of Rhesus macaques (Macaca mulatta) at Cayo Santiago
Authors: Francis George , Wang Qian 
Published: April 2023

AbstractObjectivesTo investigate whether the Cayo Santiago, Puerto Rico (Latitude: 18.1564°N; temperature range 19°C to 32°C) rhesus macaque population has acclimated to their tropical island conditions since arriving from Lucknow, India (Latitude: 26.8470°N; temperature range 8°C to 41°C) in 1938.Materials and MethodsUsing the derived skeletal collection, measurements were taken of long bone lengths, diaphyseal circumference, and body weight using 635 (237 males and 398 females) skeletally mature individuals. Measurements sampled colony members born over a 51‐year time span at Cayo Santiago, from 1951 to 2002.ResultsResults demonstrated that body weights and diaphyseal circumferences significantly declined in both males and females. Long bone lengths relative to body weight and diaphyseal circumference also increased in females. Whereas body weight, long bone length and diaphyseal circumference declined at near parallel rates in males.DiscussionThe population has acclimated to homogenous, tropical, conditions of the Caribbean island since their arrival over 80 years ago. Trends in both sexes aligned with Bergmann's rule, though females displayed a greater decline in body weight, as well as greater affinity with Allen's rule, than did males. Buffering effects related to male competition may be responsible for this discrepancy. Overall, the Cayo Santiago populations, as shown over a significant period (1951–2002) of their history, have acclimated to their island conditions by decreasing in size and altering body proportions.
The unique C‐mannosylated hypertrehalosemic hormone of Carausius morosus: Identity, release, and biological activity
Authors: Gäde Gerd , Marco Heather G. 
Published: April 2023

AbstractPrevious studies had shown that the corpora cardiaca (CC) of the Indian stick insect, Carausius morosus, synthesizes two hypertrehalosemic hormones (HrTHs)—decapeptides which differ in the way that the chromatographically less‐hydrophobic form, code‐named Carmo‐HrTH‐I, is modified by an unique C‐mannosylated tryptophan residue at position 8. The availability of milligram amounts of this modified peptide in synthetic form now makes it possible to study physico‐chemical and physiological properties. This study revealed that the synthetic peptide co‐elutes with the natural peptide from the CC chromatographically, is heat stable for at least 30 min at 100°C, and causes hyperlipemia in acceptor locusts (a heterologous bioassay) and hypertrehalosemia in ligated stick insects (conspecific bioassay). In vitro incubation of Carmo‐HrTH‐I together with stick insect hemolymph (a natural source of peptidases) demonstrated clearly via chromatographic separation that the C‐mannosylated Trp bond is stable and is not broken down to Carmo‐HrTH‐II (the more‐hydrophobic decapeptide with an unmodified Trp residue). This notwithstanding, breakdown of Carmo‐HrTH‐I did take place, and the half‐life of the compound was calculated as about 5 min. Finally, the natural peptide is releasable when CC are treated in vitro with a depolarizing saline (high potassium concentration) suggesting its role as true HrTHs in the stick insect. In conclusion, the results indicate that Carmo‐HrTH‐I which is synthesized in the CC is released into the hemolymph, binds to a HrTH receptor in the fat body, activates the carbohydrate metabolism pathway and is quickly inactivated in the hemolymph by (an) as yet unknown peptidase(s).
Effect of green marketing orientation dimensions on green innovation and organizational performance: A mediation‐moderation analysis
Authors: Negi Raghuveer , Gupta Amit Kumar , Gaur Vidhu 
Published: April 2023

AbstractThe study aims to explore the effect of dimensions of green marketing orientation (GMO) on green innovation and organizational performance utilizing the fundamental concepts of GMO theory, institutional theory, and resource‐based theory, or natural resource‐based view. In this research, we mainly explore the unplumbed effect of internal (IGMO), strategic (SGMO), and tactical green marketing orientation (TGMO) of the firm using the GMO theory. Although few scientific attempts tried to measure the effect of IGMO, SGMO, and TGMO, a majority of them disdained the idea of its integrated effect and adopted a futile approach while positioning these constructs in their model. In addition, we investigated stakeholders' role (moderating) in green innovation practices and organizational performance. The proposed model is tested using survey data collected from 201 top and middle‐level working professionals from manufacturing to service industries in India. We used a structured questionnaire and covariance‐based structure equation modeling for the path estimation. All three dimensions showed a direct positive significant effect on green innovation. Only tactical TGMO showed a direct effect on organizational performance, while the other two showed an indirect effect only on organizational performance mediated through green innovation. The study also established the moderating effect of stakeholders' view on the relationships between green innovation and organizational performance. Conclusively, we contribute to GMO theory by extending the scope for further academic/market validation and concurrently advancing managerial inferences for business strategists and market practitioners on sustainable organizational development.
Automated assessment of human engineered heart tissues using deep learning and template matching for segmentation and tracking
Authors: Rivera‐Arbeláez José M. , Keekstra Danjel , Cofiño‐Fabres Carla , Boonen Tom , Dostanic Milica , ten Den Simone A. , Vermeul Kim , Mastrangeli Massimo , van den Berg Albert , Segerink Loes I. , Ribeiro Marcelo C. , Strisciuglio Nicola , Passier Robert 
Published: April 2023

AbstractThe high rate of drug withdrawal from the market due to cardiovascular toxicity or lack of efficacy, the economic burden, and extremely long time before a compound reaches the market, have increased the relevance of human in vitro models like human (patient‐derived) pluripotent stem cell (hPSC)‐derived engineered heart tissues (EHTs) for the evaluation of the efficacy and toxicity of compounds at the early phase in the drug development pipeline. Consequently, the EHT contractile properties are highly relevant parameters for the analysis of cardiotoxicity, disease phenotype, and longitudinal measurements of cardiac function over time. In this study, we developed and validated the software HAARTA (Highly Accurate, Automatic and Robust Tracking Algorithm), which automatically analyzes contractile properties of EHTs by segmenting and tracking brightfield videos, using deep learning and template matching with sub‐pixel precision. We demonstrate the robustness, accuracy, and computational efficiency of the software by comparing it to the state‐of‐the‐art method (MUSCLEMOTION), and by testing it with a data set of EHTs from three different hPSC lines. HAARTA will facilitate standardized analysis of contractile properties of EHTs, which will be beneficial for in vitro drug screening and longitudinal measurements of cardiac function.
TP53 mutations predict poor response to immunotherapy in patients with metastatic solid tumors
Authors: Kim Ji‐Yeon , Jung Jaeyun , Kim Kyoung‐Mee , Lee Jeeyun , Im Young‐Hyuck 
Published: April 2023

AbstractBackgroundTP53 is the most commonly mutated gene across all cancer types. R175H mutation was considered structural mutation where the mutation causes misfolding of the protein and leads to a significant conformational alterations within p53's DNA binding domain. The aim of this study was to explain the reason why R175H worse the response to immunotherapy by analyzing tumor immune microenvironment through the expression of immune cells and PD‐1.Materials and MethodsPatients diagnosed with metastatic carcinoma, including colorectal cancer (CRC), breast cancer (BRCA), gastric cancer (GC), non‐small cell lung cancer (NSCLC), and 20 other cancer types, treated in a palliative setting at Samsung Medical Center between October 2019 and April 2021, were enrolled. Of these patients, those who underwent TDS analysis (TruSight™ Oncology 500 assay [TSO 500]) were finally analyzed.ResultsOf 1770 patients, 1012 (57.2%) harbored genetic alterations in TP53. All mutations were single nucleotide variants (SNVs), and the most frequent SNV was R175H (n = 84, 7.5%) which was known as one of the most common hotspot TP53 mutation. The overall survival of patients with TP53 R175H mutations was significantly worse following chemotherapy (606 vs. 456 days, p < 0.001) or immunotherapy (822 vs. 350 days, p  < 0.001) compared to those with TP53 mutation in other loci. RNA sequencing indicated that the immune response‐related pathways were downregulated in tumors harboring TP53 R175H mutation. Moreover, the expression of CD8(+) T cells PD‐1 were lowered in R175H mutation tumors. In the analysis of TP53 structural domain, compared to those having TP53 mutation in other domain, patients with mutations occurring in the nuclear exporter signal (NES) and E4F1‐binding domains had significantly worse overall survival following chemotherapy (NES: 606 vs. 451 days, p = 0.043; E4F1: 606 vs. 469 days, p = 0.046) and immunotherapy (NES: 822 vs. 403 days, p  < 0.001; E4F1: 822 vs. 413 days, p  < 0.001). In addition, tumors with TP53 mutation and co‐existing copy number amplification of CCND1, FGF4, and FGF19 in chromosome 11 conferred worse prognosis than those with only TP53 mutation (p  < 0.050).DiscussionEach TP53 mutations indicated differential treatment outcomes following chemotherapy or immunotherapy in patients with metastatic cancer. Functional analysis including RNASeq suggested that TP53 mutation downregulated immune response.ConclusionOverall, we found each TP53 mutation to indicate different prognoses in patients with metastatic tumors undergoing chemotherapy and ICI treatment. Further validations, including a prospective cohort study or a functional study, would be particularly valuable in advancing the knowledge on this aspect and developing improved prognostic parameters.
Hypoxic lung adenocarcinoma‐derived exosomal miR‐1290 induces M2 macrophage polarization by targeting SOCS3
Authors: Gu Jiahui , Yang Shengrui , Wang Xueying , Wu Yining , Wei Jia , Xu Jian 
Published: April 2023

AbstractBackgroundExosomes are critical mediators of tumor cell‐microenvironment cross talk. However, the mechanisms by which hypoxic Lung adenocarcinoma (LUAD)‐derived exosomes modulate macrophage polarization remain largely unknown. The aim of this study was to investigate the effects of hypoxic LUAD‐derived exosome on macrophage polarization and explore the underlying molecular mechanism.Materials and methodsLUAD‐derived exosomes were isolated, and then confirmed by transmission electron microscopy, nanoparticle tracking analysis, and Western blot. Internalization of exosomes in macrophages was detected by confocal microscope. Gain‐ and loss‐of‐function experiments, rescue experiments, and xenograft models were performed to uncover the underlying mechanisms of exosomal miR‐1290 induced macrophage polarization in vitro and in vivo.ResultsmiR‐1290 was enriched in hypoxic LUAD cancer cell‐derived exosomes and could be transferred to macrophages. Overexpression of miR‐1290 in macrophages‐induced polarization of M2 phenotype. Luciferase assay verified SOCS3 was the target of miR‐1290. Hypoxic LUAD cell‐derived exosomal miR‐1290 activated the STAT3 signaling pathway by targeting SOCS3 to promote M2 macrophage polarization.ConclusionHypoxic LUAD cells generate miR‐1290‐rich exosomes that promote M2 polarization of macrophages. Targeting exosomal miR‐1290 may provide a potential immunotherapeutic strategy for LUAD.
Aminoguanidine Derived N‐Rich Mesoporous Carbon Nitrides with Tunable Nitrogen Contents for Knoevenagel Condensation
Authors: Ruban Sujanya Maria , Singh Gurwinder , Ramadass Kavitha , Joseph Stalin , Ismaili Arsh , Huang Chien‐Yu , Guan Xinwei , Kumar Prashant , Sugi Yoshihiro , Vinu Ajayan 
Published: April 2023

AbstractNitrogen‐rich carbon nitrides are desired materials for base‐catalysed transformations; however, their synthesis is challenging due to the volatile nature of N at high temperatures. Herein, we report on the temperature‐controlled synthesis of ordered N‐rich mesoporous carbon nitrides (MCNs) via pyrolysis of aminoguanidine by using SBA‐15 as a hard template. The properties and the nitrogen content of the materials were tuned by varying the carbonization temperature in the range of 350–500 °C. At 350 and 400 °C, higher amounts of N could be retained in the MCN framework with the predominant formation of C3N6 having a six‐membered aromatic ring with diamino‐s‐tetrazine moiety, whereas C3N5 with 1‐amino/imino‐1,2,4‐triazole moieties was produced at 450 and 500 °C. The base catalytic activity of MCNs in Knoevenagel condensation of benzaldehyde with malononitrile revealed that the MCN‐400 exhibited the highest catalytic performance by displaying a 96.4 % product yield with toluene as a solvent. The superior catalytic activity of MCN‐400 is attributed to high N content (62.6 wt%), high surface area (235 m2 g−1), and large pore volume (0.74 cm3 g−1). The optimum temperature for obtaining the highest yield of the products is 80 °C, and the catalyst showed good cycling stability for 5 consecutive cycles.
Synthesis of Polysubstituted Enamides by Hydrogen Atom Transfer Alkene Isomerization Using Dual Cobalt/Photoredox Catalysis
Authors: Seino Yusuke , Yamaguchi Yuto , Suzuki Akihiko , Yamashita Masaaki , Kamei Yuji , Kamiyama Futa , Yoshino Tatsuhiko , Kojima Masahiro , Matsunaga Shigeki 
Published: April 2023

AbstractM‐HAT isomerization is a highly reliable method to access thermodynamically stable alkenes with high functional group tolerance. However, synthesis of heteroatom‐substituted alkenes by M‐HAT isomerization reaction is still underdeveloped. Herein, we report an enamide synthesis using M‐HAT via a combination of cobalt and photoredox catalysis. This method tolerates a variety of functional groups including haloarenes, heteroarenes, free hydroxy groups, non‐protected indoles, and drug derivatives. Furthermore, this method can isomerize styrene derivatives in good yield andE/Zselectivity.
Bromobenzene Transforms Lanthanoid Pseudo‐Grignard Chemistry
Authors: Halim Md Abdul , Guo Zhifang , Deacon Glen B. , Junk Peter C. 
Published: April 2023

AbstractDivalent lanthanoid pseudo‐Grignard reagents PhLnBr (Ln=Sm, Eu and Yb) can be easily prepared by the oxidative addition of bromobenzene (PhBr) to lanthanoid metals in tetrahydrofuran (THF). PhLnBr reacts with bulky N,N′‐bis(2,6‐di‐isopropylphenyl)formamidine (DippFormH) to generate LnII complexes, namely [Ln(DippForm)Br(thf)3]2⋅6thf (1; Sm, 2; Eu), and [Yb(DippForm)Br(thf)2]2⋅2thf (3; Yb). Samarium and europium (in 1 and 2) are seven coordinate, whereas ytterbium (in 3) is six coordinate, and all are bromine‐bridged dimers. When PhLnBr reacts with 3,5‐diphenylpyrazole (Ph2pzH), both divalent (5; [Eu(Ph2pz)2(thf)4]) and trivalent (4 a; [Sm(Ph2pz)3(thf)3]⋅3thf, 4 b; [Sm(Ph2pz)3(dme)2]⋅dme) complexes are obtained. In the monomeric compounds 4(a,b), samarium is nine coordinate but europium is eight coordinate in 5. The use of PhLnBr in this work transforms the outcomes from earlier reactions of PhLnI.
Oncofertility‐related psycho‐educational therapy for young adult patients with breast cancer and their partners: Randomized controlled trial
Authors: Koizumi Tomoe , Sugishita Yodo , Suzuki‐Takahashi Yuki , Nara Kazuko , Miyagawa Tomoko , Nakajima Misako , Sugimoto Kouhei , Futamura Manabu , Furui Tatsuro , Takai Yasushi , Matsumoto Hiroshi , Yamauchi Hideko , Ohno Shinji , Kataoka Akemi , Kawai Kiyotaka , Fukuma Eisuke , Nogi Hiroko , Tsugawa Koichiro , Suzuki Nao 
Published: April 2023

AbstractBackgroundA couples' psycho‐educational program called Oncofertility! Psycho‐Education and Couple Enrichment (O!PEACE) therapy was created and its effect when provided before cancer treatment was examined.MethodsThis multicenter randomized controlled trial with nonmasking, parallel two‐group comparison enrolled women aged 20 to 39 years with early‐stage breast cancer and their partners. They were randomly assigned to receive O!PEACE (37 couples) or usual care (37 couples). Primary end points were cancer‐related posttraumatic stress symptoms, symptoms of depression, and anxiety. Secondary end points were stress‐coping strategies, resilience, and marital relationship.ResultsWomen receiving psycho‐educational therapy had significantly reduced Impact of Event Scale‐revised version for Japanese scores (p = .011, ηp2 = = .089). For patients with Impact of Event Scale‐revised version for Japanese scores at baseline ≥18.27, O!PEACE therapy improved these scores when compared with usual care (U = 172.80, p = .027, r = 0.258). A >5‐point reduction was present in 59.3% and 30% of women in the O!PEACE therapy and usual‐care groups, respectively. For partners, O!PEACE therapy significantly improved stress‐coping strategies (95% CI, −0.60 to –0.05; p = .018, ηp2 = = .074) and escape‐avoidance marital communication (95% CI, –0.33 to –0.08; p = .001, ηp2 = .136). O!PEACE therapy significantly improved the partners' support (95% CI, 0.10–0.50; p = .001, ηp2 = .127), the rate of receiving fertility preservation consultations, and knowledge levels.ConclusionsO!PEACE therapy before cancer treatment can improve posttraumatic stress symptoms, stress‐coping behavior, and marital relationships. Larger sample sizes and longer term follow‐up are required.Plain Language Summary

A psycho‐educational program, the Oncofertility! Psycho‐Education and Couple Enrichment (O!PEACE) therapy program was developed and evaluated for women diagnosed with breast cancer and their partners.
A multicenter randomized controlled trial showed that the O!PEACE psycho‐educational therapy, with only two precancer treatment sessions, can reduce cancer‐related posttraumatic stress symptoms and improve oncofertility knowledge and marital relationships in young adult patients with breast cancer.
The therapy could also improve stress‐coping strategies in marital communications with their partners. Couples may use O!PEACE psycho‐educational therapy to consider fertility preservation and improve their psychosocial aspects.
Intersectional disparities in climate vulnerability and cancer risk
Authors: Ashad‐Bishop Kilan C. , Cruz Mayra , Bailey Zinzi D. , Kobetz Erin K. 
Published: April 2023

AbstractDespite significant progress in the early detection, treatment, and survivorship of cancer in recent decades, cancer disparities continue to plague segments of the US population. Many of these cancer disparities, especially those among historically marginalized racial and ethnic groups and those with lower socioeconomic resources, are caused and perpetuated by social and structural barriers to health. These social and structural barriers, which operate beyond the framework of cancer control, also systematically increase vulnerability to and decrease adaptive capacity for the deleterious effects of anthropogenic climate change. The established and emerging overlap between climate vulnerability and cancer risk presents complex challenges to cancer control, specifically among populations who suffer compounding hazards and intersectional vulnerabilities. By embracing these intersections, we may be able to conceptualize promising new research frameworks and programmatic opportunities that decrease vulnerability to a wide range of climate and health threats to advance health equity.
Rod bipolar cells receive cone photoreceptor inputs through both invaginating synapses and flat contacts in the mouse and guinea pig retinas
Authors: Xiao Jiayi , Wang Fenglan , Yang Qingwen , Zhong Wenhui , Zang Keduo , Tan Hang , Lin Xin , Rao Bilin , Gao Meiling , Zhang Jun 
Published: April 2023

AbstractThe light pathways are segregated into rod and cone pathways in which rods synapse with rod bipolar cells (RBCs), while cones contact cone bipolar cells (CBCs). However, previous studies found that cones can make synapse with RBCs (cone–RBC synapses) and rods can contact OFF CBC in primate and rabbit retinas. Recently, such cone–RBC synapses have been reported physiologically and morphologically in the mouse retina. Nevertheless, the precise subcellular evidence to determine whether it is the invaginating synapse or the flat contact remains absent. This is due to a lack of immunochemically verified ultrastructural data. Here, we investigated the precise expression of protein kinase C alpha (PKCα) using pre‐embedding immunoelectron microscopy (immuno‐EM) with a monoclonal antibody against PKCα, a biomarker for the RBCs. We determined the nanoscale localization of PKCα in the outer plexiform layer of the mouse and guinea pig retinas. Our results demonstrate the existence of both the direct invaginating synapse and the basal/flat contact of the cone–RBCs, providing for the first time immunochemically verified ultrastructural evidence for the cone–RBC synapse in the mouse and guinea pig retinas. These results suggest that the cross talk between cone and rod pathways is much more extensive than previously assumed.