bluuebunny/crossref_metadata_2025_split huggingface dataset:
ERN1 dependent impact of glucose and glutamine deprivations on PBX3, PBXIP1, PAX6, MEIS1, and MEIS2 genes expression in U87 glioma cells
Authors: Krasnytska Dariia O. , Viletska Yuliia M. , Minchenko Dmytro O. , Khita Olena O. , Tsymbal Dariia O. , Cherednychenko Anastasiia A. , Kozynkevych Halyna E. , Oksiom Nataliia S. , Minchenko Oleksandr H. 
Published: February 2023

Abstract

Objective. Homeobox genes play a fundamental role in the embryogenesis, but some of them have been linked to oncogenesis. The present study is aimed to investigate the impact of glucose and glutamine deprivations on the expression of homeobox genes such as PAX6 (paired box 6), PBX3 (PBX homeobox 3), PBXIP1 (PBX homeobox interacting protein 1), MEIS1 (MEIS homeobox 1), and MEIS2 in ERN1 knockdown U87 glioma cells with the intent to reveal the role of ERN1 (endoplasmic reticulum to nucleus signaling 1) signaling pathway on the endoplasmic reticulum stress dependent regulation of homeobox genes.

Methods. The control (transfected by empty vector) and ERN1 knockdown (transfected by dominant-negative ERN1) U87 glioma cells were exposed to glucose and glutamine deprivations for 24 h. The cells RNA was extracted and reverse transcribed. The expression level of PAX6, PBX3, PBXIP1, MEIS1, and MEIS2 genes was evaluated by a real-time quantitative polymerase chain reaction analysis and normalized to ACTB.

Results. It was found that glucose deprivation down-regulated the expression level of PAX6, MEIS1, and MEIS2 genes in control glioma cells, but did not significantly alter PBX3 and PBXIP1 genes expression. At the same time, ERN1 knockdown significantly modified the sensitivity of all studied genes to glucose deprivation. Other changes in gene expression were detected in control glioma cells under the glutamine deprivation. The expression of PBX3 and MEIS2 genes was down- while PAX6 and PBXIP1 genes up-regulated. Furthermore, ERN1 knockdown significantly modified the effect of glutamine deprivation on the majority of studied genes expression in U87 glioma cells.

Conclusion. The results of the present study demonstrate that the exposure of U87 glioma cells under glucose and glutamine deprivations affected the expression of the majority of the studied homeobox genes and that the sensitivity of PAX6, PBX3, PBXIP1, MEIS1, and MEIS2 genes expression under these experimental conditions is mediated by ERN1, the major pathway of the endoplasmic reticulum stress signaling.
Measuring and Analyzing the Efficiency of Firms in the Insurance Industry Using DEA Techniques
Authors: Vintilă Alexandra , Trucmel Irina-Maria , Roman Mihai Daniel 
Published: February 2023

Abstract
The insurance industry has an important role in the economy, being constantly focused on diversifying product portfolios and dispersing risks. Since the uncertainty, the asymmetric information, the current economic and social-political challenges affect the economic performance and competitiveness on the insurance market, it is necessary to focus on the evaluation of the technical efficiency of the players. One of the most complex analytical research tools with increased utility that can be applied to measure the efficiency is the Data Envelopment Analysis (DEA). Our work is designed to analyze the performance of a sample made up of the ten main players in the insurance industry in Romania. Assuming a predefined set of five inputs (total expenses, provisions, average number of employees, total placements and intangible assets) and one output (total income) selected from the firms’ balance sheets, we calculate the efficiency scores with the help of DEA techniques for each year from 2016 to 2020. Our results show that Allianz and City are the most efficient firms regardless of the model type VRS or CRS, while Groupama and Omniasig fail to operate at an optimal level in any of the analyzed periods.
Waste Management. The Trigger of Circular Economy
Authors: Maricuţ Alin-Cristian , Grădinaru Giani-Ionel , Matei Florin-Bogdan 
Published: February 2023

Abstract
The circular economy has increasingly attracted the attention of regulators as a result of the emergence of the challenges associated with climate change and the need to increase the lifetime of goods in order to reduce waste and high consumption of resources. Therefore, the paper aims to identify the current state of the circular economy in Romania by analyzing waste recovery in territorial profile. Also, another objective of the work is to identify the gaps in the territorial profile of the recovery rate of collected waste. To achieve the goals of the research, appropriate statistical methods were used in this study, such as: the Jenks algorithm and the Gini Coefficient. The main results of research suggest there are a lot of gaps in territorial profile from recycling rate perspective and a low concern about circular economy in Romania.
The Role of procollagen type 1 amino-terminal propertied (P1NP) Cytochrome P450 (CYPs) and Osteoprotegerin (OPG) as Potential Bone function markers in Prostate Cancer Bone Metastasis
Authors: Yousif Pshtiwan A. , Ismail Parween Abdulsamad 
Published: February 2023

Abstract

Background: Procollagen type I amino-terminal propeptide (PINP) is often present during osteoblast development and could be a biomarker of early bone development. Osteoprotegerin (OPG) may protect tumor cells from apoptosis. Cytochrome P450 enzymes help tumor development and treatment (CYPs). Cytochrome P450 activates and deactivates anticancer drugs and procarcinogens.

Objective: The study examined the amounts of a diagnostic marker of bone formation, the amino terminal propeptide of type I procollagen (PINP), Osteoprotegerin (OPG), and P450, in prostate cancer patients at different stages and its ability to detect osteoblastic metastases.

Methods: ELISA was used to measure PINP, OPG, and P450 levels in 30 prostate cancer patients. (n = 32) and healthy men’s serum (n = 36).

Results: Prostate cancer patients had higher blood levels of PINP, OPG, and P450 than healthy persons (301.3±134.9, 980±467.2, and 84.2±28.4 pg/mL, respectively). Compared to I+II prostate cancer patients, III+IV patients showed higher serum PINP, OPG, and P450 levels (P 0.001). OPG, P450, and PINP had statistically significant Area under the ROC curve (0.9467, P= 0.0001, 0.91, P= 0.0001, and 0.6977, P= 0.4035) in prostate cancer patients.

Conclusions: Metastatic prostate cancer patients had greater PINP, OPG, and P450 levels, according to our findings. PINP, OPG, and P450 levels may affect prostate cancer progression. These findings imply that serum PINP, OPG, and P450 levels may predict and diagnose prostate cancer.
Beyond the Whiteness
Authors: Quagliati Noemi 
Published: February 2023

Saverio Salvioni, Cava di Ravaccione, 1810–1813 (Source: Archivio di Stato Massa e Pontremoli)

Marble extraction in the Italian Apuan Alps has been known since Roman times, and its historical importance is symbolized by masterpieces of Western art history. However, the Carrara marble industry has recently received harsh criticism for operating in the protected area of the Apuan Alps Regional Park, recognized by UNESCO since 2015. Environmental and social concerns about mining have arisen from the extreme acceleration of all the productive phases of the extractive industry. From the mid-twentieth century, the exploitation of geological deposits of marble grew exponentially thanks to the development of powerful extraction technologies and a global export economy that creates only relatively few occupations in Carrara.
Within this context, photographic and cinematographic projects have increasingly focused on the environmental risks created by the marble mining industry. This article shows how visual representations of Carrara have changed in recent years via an analysis of three case studies: the internationally acclaimed documentary Anthropocene: The Human Epoch (2018), the climbing project and Italian short film Carie (Cavity 2019), and Lorenzo Shoubridge’s naturalistic photographs in Apuane: terre selvagge (Apuan Wildlands 2018).
These case studies offer an innovative perspective on the landscapes of marble extraction. Previously, these landscapes were represented following other visual trends emphasizing the technological sublime found in the geometric shapes of the white quarries, the working conditions of marble laborers, and the myth of the purity of marble used in artistic sculptures. The three examples analyzed in this paper attempt to go ‘beyond the whiteness’ by focusing on the scale of environmental destruction (Anthropocene: The Human Epoch), the more-thanhuman perspective (Apuane terre selvagge), and the social struggle for preserving a mountain region through creative solutions (Carie). In other words, new aesthetic and ethical sensibilities are challenging established twentieth-century narratives of the Carrara marble quarries by focusing on a new element: the environment.
On the question of the periodic solutions of a system of differential equations describing the oscillations of two loosely coupled Van der Pol oscillators
Authors: Баева Ольга Владимировна , Куликов Дмитрий Анатольевич 
Published: February 2023

Изучается система двух слабосвязанных полностью идентичных осцилляторов Ван дер Поля в случае диффузионной связи.В работе изучен в полном объеме вопрос о существовании и устойчивости периодических решений рассматриваемой системы. Показано, что у нее могут быть периодические решения трех типов, которые порождают циклы Андронова-Хопфа, противофазный, и третий тип циклов синхронизации: асимметричные циклы. Анализ задачи использовал метод нормальных форм Пуанкаре-Дюлака, а также метод интегральных многообразий.
We study a system of two weakly coupled completely identical van der Pol oscillators in the case of diffusion coupling. the question of the existence and stability of periodic solutions of the system under consideration. It is shown that it can have periodic solutions of three types, which generate Andronov-Hopf cycles, antiphase, and the third type of synchronization cycles: asymmetric cycles. The analysis of the problem used the Poincare-Dulac method of normal forms, as well as the method of integral manifolds.
Pengaruh Latihan Kekuatan Arm Muscles dan Abdominal Muscles Terhadap Shooting Bola Tangan (Studi Pada Atlet Bola Tangan Bojonegoro)
Authors: Al-ayyubi Iwan Burhannudin , Januardi Irawan Roy 
Published: February 2023

Latar Belakang: Penelitian ini bertujuan untuk mengetahui pengaruh kekuatan otot perut dan otot lengan terhadap lemparan (shooting) pada atlet bola tangan Bojonegoro.
Metode: Dalam penelitian metode yang digunakan adalah deskriptif kuantitatif. Untuk mengetahui hasil lemparan (shooting) ini diukur menggunakan instrumen standing shoot test, sedangkan variabel otot perut dan otot lengan menggunakan instrumen sit up dan push up.
Hasil: Hasil dari penelitian ini menunjukkan bahwa shooting bola tangan di pengaruhi oleh banyak aspek, salah satunya adalah kekuatan otot lengan dan otot perut.
Kesimpulan: Secara individu kekuatan otot lengan memberikan pengaruh paling besar terhadap variabel shooting yang dilakukan dalam bola tangan. Kesimpulannya variabel kekuatan otot lengan dan otot perut sangat berpengaruh terhadap variabel shooting yang dilakukan dalam olahraga bola tangan secara individual maupun bersama-sama.
PENGARUH SISTEM PENILAIAN KINERJA MENGGUNAKAN RATING BINTANG TERHADAP KINERJA DENGAN DISIPLIN KERJA SEBAGAI VARIABEL MEDIASI
Authors: Widyaningtyas Ambar Sari , Suharti Lieli 
Published: February 2023

Penilaian kinerja adalah hasil atau tingkat keberhasilan seseorang selama periode tertentu dalam melaksanakan tugas. Sedangkan pemberian rating merupakan bagian dari evaluasi terhadap kinerja yang dicoba oleh karyawan. Penelitian ini bertujuan untuk mengetahui pengaruh sistem penilaian kinerja menggunakan rating bintang terhadap kinerja dengan disiplin kerja sebagai variabel mediasi pada driver gojek di Kabupaten Semarang. Penelitian ini menggunakan jenis dan desain penelitian kuantitatif. Teknik pengambilan sampel yang digunakan merupakan non probability sampling yaitu accidental sampling. Metode analisis data menggunakan regresi sederhana dan peran mediasi menggunakan uji sobel. Hasil penelitian membuktikan bahwa sistem penilaian kinerja dengan rating bintang berpengaruh positif terhadap disiplin kerja driver, disiplin kerja dan sistem penilaian kinerja dengan rating bintang berpengaruh positif signifikan terhadap kinerja driver, dan disiplin kerja mampu memediasi pengaruh sistem penilaian kinerja dengan rating bintang terhadap kinerja.
Quantitative Structure-Activity relationship, Molecular Docking and ADMET Screening of Tetrahydroquinoline Derivatives as Anti-Small Cell Lung Cancer Agents
Authors: Erazua Ehimen Annastasia , Oyebamiji Abel Kolawole , Akintelu Sunday Adewale , Adewole Pelumi Daniel , Adelakun Adedayo , Adeleke Babatunde Benjamin 
Published: February 2023

Lung carcinoma (LC) is responsible for almost one-third of all cancer fatalities worldwide. Tetrahydroquinoline is an organic molecule that is the semi-hydrogenated derivative of quinoline and could be found in several naturally occurring compounds such as flindersine, oricine etc. Some tetrahydroquinoline derivatives with pyrazole and hydrazide moieties were evaluated in silico against A549 (human lung cancer cell lines). The quantitative structural-activity relationship (QSAR) model created was statistically significant with validation metrics of R2 (0.9525), R2adj (0.9314), and CV.R (0.9719). The molecular docking analysis revealed that compound C14 demonstrated the best binding affinity towards the studied protein with binding affinity value of –10.1 kcal mol–1 (4LRM). This is in accordance with the experimental result (IC50 = 0.69). The factors observed for ADME&T correlated well with the factors observed for the referenced drug. This study indicates that compounds C1 and C9 can be further developed as anti-epidermal growth factor receptor (EGFR) compounds. Thus, our findings may open door for the design and development of library of efficient Tetrahydroquinoline-based drug-like compounds as potential anti-LC agents.
Limits of time-of-flight-diffraction method applicability at pipeline transport facilities
Authors: Колесников Олег Игоревич , Гейт Алексей Викторович , Голосов Петр Сергеевич 
Published: February 2023

Одним из главных факторов обеспечения надежности и безопасности объектов магистральных трубопроводов является оценка их технического состояния как на стадии строительства, так и в процессе эксплуатации. Объектом исследования определен дифракционно-временной метод ультразвукового контроля (ДВМ), основным преимуществом которого относительно эхо-метода является, по заявлениям производителей оборудования, малая зависимость вероятности выявления дефекта от его ориентации и формы и, как следствие, повышение достоверности оценки высоты и глубины залегания дефекта. Целью работы является совершенствование системы оценки качества сварных соединений на объектах трубопроводного транспорта нефти и нефтепродуктов путем уточнения границ применимости ДВМ. В качестве предмета исследования рассматриваются факторы, определяющие указанные границы: ограничение области контроля из-за наличия мертвых зон, ограничение возможности измерения высоты дефекта параметром разрешающей способности метода, ограничения вследствие влияния особенностей геометрии или коррозионных повреждений сварных соединений, ограничение по ориентации, форме и месту расположения дефектов. В результате выполненных исследований выявлены границы применимости дифракционно-временного метода контроля на объектах трубопроводного транспорта, обусловленные исследованными факторами.
One of the main factors of ensuring the reliability and safety of main pipeline facilities is the estimation of their technical condition both at the construction stage and during operation. The object of the study is the ultrasonic time-of-flight-diffraction method (TOFD). According to the information from the equipment manufacturers, TOFD main advantage relative to the echo method is the low dependence of the defect detection probability on its orientation and shape and, as a result, an increase in the reliability of defect height and depth estimation. The purpose of the work is to improve the system for assessing the quality of welded joints at oil and oil product pipeline facilities by clarifying the limits of TOFD applicability. The factors that determine these limits are considered as the study subject: the limitation of inspection area due to the presence of dead areas, the limitation of the possibility to measure the defect height by the resolution parameter of the method, the limitations imposed by the geometry of welded joints, limitation on the orientation, shape and location of defects. As a result of the performed studies, the limits of the time-of-flight-diffraction method applicability at pipeline transport facilities, caused by the studied factors, have been revealed.
Electrodeposición de paladio sobre un electrodo de HOPG en soluciones amoniacales
Authors: Garrido Márquez David , Mendoza-Huizar L.H. 
Published: February 2023

En el presente trabajo se llevó a cabo un estudio cinético y morfológico de la electrodeposición de paladio en un electrodo de grafito pirolítico altamente orientado a partir de una solución [0.001 M PdCl2 + 1 M NH4Cl (pH=7)]. A partir de un estudio potenciostático se calculó el coeficiente de difusión (1.21x10-6 cm2 s-1), el número de sitios activos de nucleación (N0), la velocidad de nucleación (A) y la constante del proceso de reducción de protones (kPR). Se encontró que los valores de A, N0 y kPR son dependientes del potencial y estos incrementan con el aumento del mismo. A mayores sobrepotenciales, es posible inducir a la formación de pequeños cúmulos de Pd con una altura de 5 nm y un tamaño promedio de 20-30 nm de diámetro.
“A Dona da Rua (...)”: transcrevendo o projeto de pesquisa de Satine (Rodrigues Borges) junto ao PPGAnt/UFGD
Authors: Borges Satine Rodrigues , Becker Simone , Seraguza Lauriene , Dos Santos Yuri Tomaz 
Published: February 2023

A decisão de veicular o projeto de pesquisa de Satine Rodrigues Borges submetido ao edital de 2010-2011 da FUNDECT/MS, a fim de ser desenvolvido ao largo dos anos de 2012 e 2013, junto ao mestrado acadêmico em Antropologia da UFGD – o PPGAnt, e sob a orientação de Simone Becker, se deu no “apagar das luzes”.
O dossiê "Memórias e Práticas {Sociais} de Resistências" já estava em vias de se findar, quando o projeto de Satine saltou em meio às revisões de arquivos do “google drive” que Simone estava a fazer. Assim, rimando Memórias e Práticas Sociais de Resistências à vida em potência que pulsa em cada uma das pessoas que com Satine conviveram, ao lembrarmos dela. E àquelas tocadas a partir de suas memórias.
Analysis of Rentability Trends of Islamic Commercial Banks in the Covid-19 Pandemic
Authors: Kusuma Alto Wirahadi , Muhajir Ammar , Lutfiah Lutfiah , Rahmawati Rafika 
Published: February 2023

<p>The Covid 19 pandemic has caused possible risks to the financial performance of Islamic banking. This study aimed to determine the rentability performance level predictions of Bank Muamalat Indonesia, Bank Mega Syariah, and Bank KB Bukopin Syariah by using the ratio of Return on Assets (ROA) and Return on Equity (ROE) in the pandemic for the period December 2021 to December 2023. The Islamic commercial bank was chosen because its rentability performance showed different trends during the pandemic. The research methods used the quantitative and trend analysis techniques with the least square method. The results have indicated that the rentability performance level of Bank Muamalat Indonesia and Bank KB Bukopin Syariah in terms of the ratio of Return on Assets (ROA) and Return on Equity (ROE) was predicted to decrease from December 2021 to December 2023. Meanwhile, the rentability performance level of Bank Mega Syariah in terms of the ratio of Return on Assets (ROA) and Return on Equity (ROE) was predicted to increase from December 2021 to December 2023. Concerning this, the research is hoped to contribute as reference material for further academic research and as material for consideration in determining policies for Islamic commercial banks.</p>
Economic Exploitation of Children: Returning Child Labor to the World of Education Through Interpersonal Communication Towards Equal Education
Authors: Sudarto Aye , Mustofa Muhamad Bisri , Malik Anas 
Published: February 2023

<p class="abstrak">Low family incomes force children to support households and become Child Labourers (PA) in the agricultural and household sectors. The agricultural sector is still the main source of income for most Indonesians; at least 70% of the archipelago's population is dependent on the agricultural sector. However, rural poverty remains relatively high. At least 16% of rural areas are poor compared to 9.9% of urban areas. Farm labourers have not been able to benefit significantly from economic growth, as it is undeniable that several problems have caused the agricultural sector to lag behind other sectors. This qualitative study will describe the processes that influence and shift the mindset of children and parents of child laborers to change their mindset and desire to continue their education. Economic exploitation in children is actually carried out by families, for example, by placing, allowing, and telling children to work as a form of economic exploitation. Good economic exploitation will result in good child development, but bad exploitation will have a bad impact on children, including lying, insensitivity, low self-esteem, developmental disorders, oppressing the weak, difficulty forming and interacting with the environment, anxiety, low self-esteem, and personality disorders. Equality education is another way for children to re-enter school. It is necessary to optimise all stakeholders to eliminate child labour and return child labourers to school. It is necessary to strengthen equivalency schools in various places so that they can be reached by children with economic difficulties or difficulties integrating into public schools. Preventive efforts must be made to ensure that children do not drop out of school and are prepared to enter the global workforce, including introducing and raising awareness of the importance of education, as well as providing affordable education to all.</p>