bluuebunny/crossref_metadata_2025_split huggingface dataset:
Percepção de boca seca em adultos usuários de próteses removíveis
Authors: Costa Monalisa Sena da , Faria Natália Spadini de , Sousa Yara Terezinha Corrêa Silva , Silva Silvio Rocha Corrêa da 
Published: March 2023

Objetivo: O objetivo deste estudo foi avaliar a percepção de boca seca em uma amostra de pacientes, de uma clínica de um curso de odontologia, usuários de próteses totais.
Métodos: Fizeram parte do estudo 80 pacientes, que responderam a um questionário com 12 questões que caracterizavam o participante e abordava a sensação de boca seca e como a pessoa a percebia. O questionário foi pré-testado antes de sua aplicação definitiva. A análise estatística foi realizada por meio do Teste Exato de Fischer para identificar a associação da xerostomia com as variáveis independentes, com nível de significância de 5%.
Resultados: Os participantes do estudo tinham, em média, 62,3 anos de idade e 55% eram do gênero feminino. Metade (50,0%) dos participantes percebiam a boca seca e 72,5% apresentavam alguma doença crônica, principalmente a hipertensão (36,1%) e a diabetes (17,1%) e estas doenças se refletiam na alta (78,8%) utilização de medicamentos de uso contínuo. Apresentavam hábitos bucais nocivos 38,8% dos participantes, principalmente o tabagismo e o bruxismo. A sensação de boca seca foi associada ao gênero, a presença de mau hálito, ao uso de medicamentos contínuos e a sensação de ardência na boca.
Conclusão: A partir dos dados coletados pode-se concluir que a xerostomia foi frequente na população estudada e deve ter impacto negativo na qualidade de vida dessas pessoas.
Descritores: Saliva. Xerostomia.
Avaliação da condição bucal de pacientes com doença renal crônica em tratamento na Fundação Hospital Adriano Jorge – AM
Authors: Gonçalves Jéssica Lourdes de Aguiar , Ribeiro Eliane de Oliveira Aranha , Prestes Gimol Resende , Soares Keuly Sousa 
Published: March 2023

Objetivo: Avaliar a condição bucal e o conhecimento a respeito da importância do atendimento odontológico de indivíduos com doença renal crônica (DRC) em tratamento hemodialítico.
Métodos: Estudo transversal descritivo, com avaliação de 50 pacientes, em atendimento no Serviço de Hemodiálise da Fundação Hospital Adriano Jorge na cidade de Manaus-AM. Foram coletados dados socioeconômicos, saúde geral, higiene bucal, autopercepção dos problemas bucais. Um único examinador calibrado realizou o exame clínico intrabucal. Os resultados quantitativos e qualitativos foram dispostos em tabelas e gráficos, utilizando Excel®, Word®. O programa Excel foi utilizado para formar um banco de dados que foram analisados e transformados em gráficos ou tabelas para demonstrar os resultados obtidos com a pesquisa.
Resultados: A maioria dos participantes era do sexo masculino (62%). Houve o predomínio da hipertensão arterial (54%) como doença sistêmica de base. Em relação à autopercepção dos problemas bucais, a xerostomia teve maior frequência (56 %). A maioria dos pacientes realizava três escovações diárias (46%) e não utilizavam fio dental (58%). Dentre as manifestações bucais, (66%) apresentou palidez na mucosa, seguido de recessão gengival (54%). Houve relato de (94%) dos participantes de não terem recebido informações sobre escovação, como evitar cárie dentária e cuidados de higiene bucal. Nestes pacientes com DRC em hemodiálise, notou-se deficiência nos hábitos de higiene bucal.
Conclusão: A motivação e orientação dos cuidados odontológicos devem ser enfatizadas pelo dentista a fim de melhorar a saúde bucal e consequentemente a saúde sistêmica.
Descritores: Diálise renal. Nefropatias. Higiene bucal.
Avaliação da prática de prescrição de antibióticos pelos cirurgiões-dentistas da Rede Pública de um município de médio porte
Authors: Lucchette Ana Carolina Torres , Tenani Carla Fabiana , Possobon Rosana de Fátima , Batista Marília Jesus 
Published: March 2023

Introdução: O cirurgião-dentista como um profissional da saúde, utiliza amplamente antibióticos na sua prática clínica, por isso é relevante conhecer como tem sido a prescrição desse fármaco e a influência da prescrição pelos profissionais frente à resistência bacteriana.
Objetivo: Conhecer a conduta para as prescrições de antimicrobianos pelos cirurgiões-dentistas (CDs) da rede pública, de um município de médio porte do interior do estado de São Paulo.
Materiais e Métodos: Todos CDs da rede pública do município de Piracicaba–SP foram convidados a participar (N=79). A coleta de dados foi realizada em 2015, por meio de uma entrevista, questionário estruturado, como entrevista, nas unidades de saúde. O questionário continha questões sobre as características dos CDs, condições clínicas e sistêmicas que levariam ou não a prescrição de antibiótico, droga de escolha e forma de prescrição. Foi realizada a análise descritiva, utilizando o programa SPSS ® (Statistical Package for the Social Sciences) versão 20.0 para Microsoft Windows.
Resultados: No total, 74 CDs aceitaram participar da pesquisa, e 68,9% (N=51) relataram prescrever antimicrobianos para abscesso localizado, alveolite seca, pulpite aguda. Situações sistêmicas que necessitam de profilaxia antibiótica eram desconhecidas pelos CDs, sendo que 56,8% (N=42) não sabiam a conduta correta com a prescrição em casos de pacientes que fazem uso de bisfosfonatos e 35,0% (N=26) após a quimioterapia. A droga de escolha de 97,3% dos CDs foi a amoxicilina.
Conclusão: Os resultados obtidos pelos relatos das condutas terapêuticas permitiram concluir que houve um excesso de prescrição de antibióticos, inclusive para situções clínicas que não havia necessidade, sendo o mais receitado a amoxicilina. Deve-se pensar no desenvolvimento de estratégias públicas de educação permanente, voltadas para os profissionais de odontologia, para o controle da resistência bacteriana.
Descritores: Saúde pública. Antibióticos. Odontólogos.
POLICY CONSIDERATIONS FOR THE UTILIZATION AND RATIONALIZATION OF PPE IN MATERNAL CARE DURING COVID-19 PANDEMIC – LITERATURE REVIEW
Authors: Soebangil Mas Aditya , Gani Ascobat , Oktamianti Puput 
Published: March 2023

Policies regarding utilizing and rationalizing Personal Protective Equipment (PPE) during the COVID-19 pandemic challenge every healthcare service provider. Within the maternal health sector, it is suspected that the negative perception of patients and the lack of implementation and compliance with infection prevention and control policies disrupt the quality of care provided. This research is a narrative review highlighting all proper considerations for using and rationalizing PPE within the maternal health sector. Articles are gathered and filtered from well-known scientific publishing sites, and ten articles became the main discussion of this research. The utilization of PPE impacts all levels of maternal health service, from prenatal care to postnatal and neonatal care. Standardized PPE utilization and rationalization are needed to maintain the quality of care and reduce any negative impacts that PPE use might bring. Policies regarding the use of PPE must be well thought out to ensure that it will benefit its user without the risks of its side effects.
Effect of Organic Manures, Biofertilizers and Cow Urine Spray on Growth, Yield and Quality of Clusterbean (Cyamopsis tetragonoloba L.)
Authors: Ghoya Snehal K. , Kumar Mukesh , Patel C. K. 
Published: March 2023

A field experiment was conducted during the kharif season of the year 2021 at Agronomy Instructional Farm, Department of Agronomy, CPCA, Sardarkrushinagar Dantiwada Agricultural University, Sardarkrushinagar to evaluate the “Effect of organic manures, biofertilizers and cow urine spray on growth, yield and quality of clusterbean (Cyamopsis tetragonoloba L.)” under loamy sand soil. The experiment was laid out in randomized block design with three replications. Thirteen treatments comprises different organic sources viz., T1: 100% RDF through chemical fertilizers (control), T2: 100% RDN through castor cake (CC), T3: 100% RDN through poultry manure (PM), T4: 100% RDN through neem cake (NC), T5: 75% RDN through CC + biofertilizers (NPK), T6: 75% RDN through PM + biofertilizers (NPK), T7: 75% RDN through NC + biofertilizers (NPK), T8: 75% RDN through CC + 5% cow urine, T9: 75% RDN through PM + 5% cow urine, T10: 75% RDN through NC + 5% cow urine, T11: 75% RDN through CC + biofertilizers (NPK) + 5% cow urine, T12: 75% RDN through PM + biofertilizers (NPK) + 5% cow urine and T13: 75% RDN through NC + biofertilizers (NPK) + 5% cow urine. The results revealed that an application of 75% RDN through PM + biofertilizers (NPK) + 5% cow urine (T12) recorded significantly higher plant height, number of branches per plant, number of pods per plant, seed index, seed yield, stover yield and crude protein content in seed. However, gum content in seed was recorded significantly higher in treatment T13. Therefore, the application of different organic sources of nutrients treatment application significantly influenced the growth, yield and quality of clusterbean. It is concluded that the combined application of poultry manure, biofertilizers and cow urine spray (T12) can be obtained maximum seed and stover yield with better seed quality.
Best practices for documentation of psychotropic drug-drug interactions in an adult psychiatric clinic
Authors: Collins Kathryn , Dopheide Julie A. , Wang Mengxi , Keshishian Talene 
Published: March 2023

AbstractIntroductionPsychotropic drug-drug interactions (DDIs) contribute to adverse drug events, but many go undetected or unmanaged. Thorough documentation of potential DDIs can improve patient safety. The primary objective of this study is to determine the quality of and factors associated with documentation of DDIs in an adult psychiatric clinic run by postgraduate year 3 psychiatry residents (PGY3s).MethodsA list of high-alert psychotropic medications was identified by consulting primary literature on DDIs and clinic records. Charts of patients prescribed these medications by PGY3 residents from July 2021 to March 2022 were reviewed to detect potential DDIs and assess documentation. Chart documentation of DDIs was noted as none, partial, or complete.ResultsChart review identified 146 DDIs among 129 patients. Among the 146 DDIs, 65% were not documented, 24% were partially documented, and 11% had complete documentation. The percentage of pharmacodynamic interactions documented was 68.6% with 35.3% of pharmacokinetic interactions documented. Factors associated with partial or complete documentation included diagnosis of psychotic disorder (p = .003), treatment with clozapine (p = .02), treatment with benzodiazepine-receptor agonist (p &lt; .01), and assumption of care during July (p = .04). Factors associated with no documentation include diagnosis of “other (primarily impulse control disorder)” (p &lt; .01) and taking an enzyme-inhibiting antidepressant (p &lt; .01).DiscussionInvestigators propose best practices for psychotropic DDI documentation: (1) description and potential outcome of DDI, (2) monitoring and management, (3) Patient education on DDI, and (4) patient response to DDI education. Strategies to improve DDI documentation quality include targeted provider education, incentives, and electronic medical record “DDI smart phrases.”
First-line Systemic Treatment Options for Metastatic Castration-Sensitive Prostate Cancer
Authors: Riaz Irbaz Bin , Naqvi Syed Arsalan Ahmed , He Huan , Asghar Noureen , Siddiqi Rabbia , Liu Hongfang , Singh Parminder , Childs Daniel S. , Ravi Praful , Hussain Syed A. , Murad Mohammad Hassan , Boorjian Stephen A. , Sweeney Christopher , Van Allen Eliezer M. , Bryce Alan H. 
Published: March 2023

ImportanceThe effectiveness of triplet therapy compared with androgen pathway inhibitor (API) doublets in a heterogeneous patient population with metastatic castration-sensitive prostate cancer (mCSPC) is unknown.ObjectiveTo assess the comparative effectiveness of contemporary systemic treatment options for patients with mCSPC across clinically relevant subgroups.Data SourcesFor this systematic review and meta-analysis, Ovid MEDLINE and Embase were searched from each database’s inception (MEDLINE, 1946; Embase, 1974) through June 16, 2021. Subsequently, a “living” auto search was created with weekly updates to identify new evidence as it became available.Study SelectionPhase 3 randomized clinical trials (RCTs) assessing first-line treatment options for mCSPC.Data Extraction and SynthesisTwo independent reviewers extracted data from eligible RCTs. The comparative effectiveness of different treatment options was assessed with a fixed-effect network meta-analysis. Data were analyzed on July 10, 2022.Main Outcomes and MeasuresOutcomes of interest included overall survival (OS), progression-free survival (PFS), grade 3 or higher adverse events, and health-related quality of life.ResultsThis report included 10 RCTs with 11 043 patients and 9 unique treatment groups. Median ages of the included population ranged from 63 to 70 years. Current evidence for the overall population suggests that the darolutamide (DARO) triplet (DARO + docetaxel [D] + androgen deprivation therapy [ADT]; hazard ratio [HR], 0.68; 95% CI, 0.57-0.81), as well as the abiraterone (AAP) triplet (AAP + D + ADT; HR, 0.75; 95% CI, 0.59-0.95), are associated with improved OS compared with D doublet (D + ADT) but not compared with API doublets. Among patients with high-volume disease, AAP + D + ADT may improve OS compared with D + ADT (HR, 0.72; 95% CI, 0.55-0.95) but not compared with AAP + ADT, enzalutamide (E) + ADT, and apalutamide (APA) + ADT. For patients with low-volume disease, AAP + D + ADT may not improve OS compared with APA + ADT, AAP + ADT, E + ADT, and D + ADT.Conclusions and RelevanceThe potential benefit observed with triplet therapy must be interpreted with careful accounting for the volume of disease and the choice of doublet comparisons used in the clinical trials. These findings suggest an equipoise to how triplet regimens compare with API doublet combinations and provide direction for future clinical trials.
Electropolymerized Poly(3,4‐ethylenedioxythiophene) Coatings on Porous Carbon Electrodes for Electrochemical Separation of Metals
Authors: Boz Emre B. , Fritz Marcell , Forner‐Cuenca Antoni 
Published: March 2023

AbstractElectrode‐assisted techniques are well suited for the separation of ions from solutions with reduced energy and chemical consumption. This emerging platform can benefit greatly from the convection enhanced and zero‐gap reactor designs unlocked by macroporous electrodes, but immobilizing ion‐selective layers on such complex 3D architectures is challenging. Electropolymerization of conductive polymers is proposed as a coating methodology to fabricate highly conformal coatings with electrochemically switchable ion‐exchange functionality. To demonstrate this, the synthetic parameters, resulting morphology, and ionic separation performance of poly(3,4‐ethylenedioxythiophene) (PEDOT) on commercially available carbon paper electrodes are studied. Electropolymerization of PEDOT in organic solvents results in rougher morphologies with high sensitivity to electrochemical protocols employed. When polymerized in aqueous solutions of poly(4‐styrenesulfonate) (PSS−), the resulting PEDOT/PSS blend polymer forms smooth coatings with a controllable thickness down to 0.1 µm. With appropriate voltage bias, PEDOT/PSS coated electrodes can take up and release Ni2+ in the presence of excess Na+. Increasing the coating thickness decreases the adsorption capacity due to mass transfer limitations, and the maximum adsorption capacity for Ni2+ is reached for the thinnest coatings at 228 mg g−1. Through a systematic study of PEDOT/PSS coated carbon paper, electropolymerization is identified to be a promising avenue for porous electrode functionalization.
An Effective Spectral Processing Method for Low‐Cost Fiber Loop Ring‐Down Systems
Authors: Cha Guozhi , Wang Ruoyu , Ma Jiangtao , Shao Guifang , Liu Tundong 
Published: March 2023

AbstractFiber loop ring‐down spectroscopy (FLRDS) is a highly sensitive spectroscopic technology. Here, a spectral processing method is proposed for low‐cost fiber loop ring‐down systems. In the proposed method, the amplitude modulation theory is used to establish a new ring‐down spectral model, and the particle swarm optimization algorithm is introduced into FLRDS. The experimental results demonstrate that the proposed method can effectively process the ring‐down spectral signals acquired from the low‐cost fiber loop ring‐down system. Moreover, this method demonstrates higher accuracy and stronger adaptability than the current widely used method. Owing to its excellent performance, the proposed method has considerable potential to be applied in low‐cost fiber loop ring‐down systems.
All‐Natural Immunomodulatory Bioadhesive Hydrogel Promotes Angiogenesis and Diabetic Wound Healing by Regulating Macrophage Heterogeneity
Authors: Fu Ya‐Jun , Shi Yi‐Feng , Wang Li‐Ya , Zhao Yi‐Fan , Wang Rao‐Kaijuan , Li Kai , Zhang Shu‐Ting , Zha Xiang‐Jun , Wang Wei , Zhao Xing , Yang Wei 
Published: March 2023

AbstractMacrophages are highly heterogeneous and exhibit a diversity of functions and phenotypes. They can be divided into pro‐inflammatory macrophages (M1) and anti‐inflammatory macrophages (M2). Diabetic wounds are characterized by a prolonged inflammatory phase and difficulty in healing due to the accumulation of pro‐inflammatory (M1) macrophages in the wound. Therefore, hydrogel dressings with macrophage heterogeneity regulation function hold great promise in promoting diabetic wound healing in clinical applications. However, the precise conversion of pro‐inflammatory M1 to anti‐inflammatory M2 macrophages by simple and biosafe approaches is still a great challenge. Here, an all‐natural hydrogel with the ability to regulate macrophage heterogeneity is developed to promote angiogenesis and diabetic wound healing. The protocatechuic aldehyde hybridized collagen‐based all‐natural hydrogel exhibits good bioadhesive and antibacterial properties as well as reactive oxygen species scavenging ability. More importantly, the hydrogel is able to convert M1 macrophages into M2 macrophages without the need for any additional ingredients or external intervention. This simple and safe immunomodulatory approach shows great application potential for shortening the inflammatory phase of diabetic wound repair and accelerating wound healing.
How prenatal cortisol levels relate to grandmother‐mother relationships among a cohort of Latina women
Authors: Fox Molly M. , Knorr Delaney A. , Kwon Dayoon , Wiley Kyle S. , Parrish Michael H. 
Published: March 2023

AbstractIntroductionAs part of the human reproductive strategy, mothers receive childcare assistance from others. For kin, allomothers are adaptively incentivized to provide assistance due to inclusive fitness benefits. Previous studies across a broad range of populations identify grandmothers as particularly consistent allomothers. Minimal attention has been paid to the possibility that allomothers may begin investing in offspring quality during the prenatal stage of life. Here, we innovate within the area of grandmother allocare research by examining the prenatal stage of life and biopsychosocial mechanisms by which prenatal grandmother effects may be enacted.MethodsData derive from the Mothers' Cultural Experiences study, a cohort of 107 pregnant Latina women in Southern California. At <16 weeks' gestation, we administered questionnaires, collected morning urine samples, and measured cortisol by enzyme‐linked immunosorbent assay, correcting for specific gravity. We measured the soon‐to‐be maternal and paternal grandmothers' relationship quality, social support, frequency of seeing each other, communicating, and geographic proximity to pregnant mothers, that is, their daughters and daughters‐in‐law. These measures were self‐reported by the pregnant mothers. We assessed how grandmother constructs related to the pregnant women's depression, stress, anxiety, and cortisol levels.ResultsWe observed benefits conferred by maternal grandmothers for mothers' prenatal mental health and lower cortisol levels. Paternal grandmothers also conferred mental health benefits to pregnant daughters‐in‐law, but higher cortisol levels.ConclusionOur results suggest that grandmothers, especially maternal grandmothers, are able to improve their inclusive fitness by caring for pregnant daughters, and allomother support may positively impact prenatal health. This work extends the traditional cooperative breeding model by identifying a prenatal grandmother effect, and, by examining a maternal biomarker.
Determinants and clinical outcomes of stroke following revascularization among patients with reduced ejection fraction
Authors: Wang Shaoping , Ran Yuhua , Cheng Shujuan , Lyu Yi , Liu Jinghua 
Published: March 2023

AbstractObjectiveStoke after revascularization including both percutaneous coronary intervention (PCI) and coronary artery bypass grafting (CABG) is an uncommon but devastating complication. Patients with reduced ejection fraction (EF) had an increased risk of stroke after revascularization. However, little is known about the determinants and outcomes of stroke among patients with reduced EF following revascularization.Materials and MethodsA cohort study of patients with preoperative reduced EF (≤40%) who received revascularization by either PCI or CABG between January 1, 2005 and December 31, 2014 was performed. Multivariate logistic regression was used to identify independent correlates of stroke. Logistic regression models were applied to evaluate the association of stroke with clinical outcomes.ResultsA total of 1937 patients were enrolled in this study. Of these, 111 (5.7%) patients suffered from stroke during the median 3.5‐year follow‐up. Older age (odds ratio [OR], 1.03; 95% CI, 1.01–1.05; p = .009), history of hypertension (OR, 1.79; 95% CI, 1.18–2.73; p = .007), and history of stroke (OR, 2.00; 95% CI, 1.19–3.36; p = .008) were found to be independent predictors for stroke. Patients with and without stroke had similar risk of all‐cause death (OR, 0.91; 95% CI, 0.59–1.41; p = .670). However, stroke was associated with higher odds ratio of heart failure (HF) hospitalization (OR, 2.77; 95% CI, 1.74–4.40; p < .001) and composite end point (OR, 1.61; 95% CI, 1.07–2.42; p = .021).ConclusionsFurther research appears warranted to minimize the complication of stroke and improve long‐term outcomes among patients with reduced EF who underwent such high risk revascularization procedural.
Thrombocytosis as a paraneoplastic syndrome in metastatic malignant peritoneal mesothelioma of biphasic morphology mimicking ovarian adenocarcinoma: A case report
Authors: Alhamadh Moustafa S. , Alanazi Rakan B. , Wadaan Osama Mohaamad , Alhabeeb Abdulrahman Yousef , Alkaiyat Mohammad , Aljarbou Ohoud Zaid , Sabatin Fouad 
Published: March 2023

AbstractMalignant peritoneal mesothelioma (MPM) is a rare malignancy, presenting with non‐specific and potentially‐misleading manifestations. It represents a diagnostic pitfall as it mimics ovarian carcinoma. Maintaining a low diagnostic threshold, obtaining a detailed history, and utilizing immunohistochemical markers to diagnose MPM is crucial as early diagnosis and treatment might improve survival.