bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characteristics of Comorbid Physical Disease in Patients with Severe Mental Illness in South Korea: A Nationwide Population-Based Study (2014-2019)
Authors: Na Eun Jin , Lee JungSun , Sohn Jee Hoon , Yang Mi , Park Yoomi , Sim Hyun-Bo , Lee Hae-woo 
Published: March 2023

Abstract

Purpose: The purpose of this study was to identify the associations of chronic physical disease between patients with severe mental illness and the general population of South Korea.
Methods: This study was conducted with National Health Insurance Corporation (NHIC) data from 2014 to 2019. A total of 842,459 people were diagnosed with severe mental illness (SMI) in this period, and the same number of controls were established by matching by sex and age. A descriptive analysis was conducted on the sociodemographic characteristics of patients with SMI. Conditional logistic regression analysis was performed to identify the associations between comorbid physical disease in patients with SMI and those of the general population. SAS Enterprise Guide 7.1 (SAS, Inc, Cary, NC) were used to perform all statistical tests.
Result: The analysis revealed significant differences in medical insurance, income level, and Charlson Comorbidity Index (CCI) weighted by chronic physical disease, between patients with severe mental illness and the general population. Conditional logistic regression analysis between the two groups also revealed significant differences in all nine chronic physical diseases.
Conclusions: The study found that people with severe mental illness had more chronic comorbid physical diseases than the general population. Therefore, people with severe mental illness have a reduced quality of life and a higher risk of excess mortality.
Study on coastal sediment budget imbalance in cells resulted from land cover change in the savanna desertification area, west Hainan Island (China)
Authors: Luo Shilong , Jin Ruifang , Wang Jiaxin , Wang Xinhao , Huang Manyu , Peng Mengjiao , Xu Shuolei , Zhao Ruolin 
Published: March 2023

Abstract
Based on the superior natural environment of the coastal zone, the construction of the coastal zone has developed rapidly in recent years. In order to better adapt to the coastal zone and protect the coastal zone resources, we need to fully understand the sedimentary dynamic environment of the coastal zone, so this study was carried out. In this paper, the data of geographical environment and climatic factors in the study area are collected. Field observation was carried out in the study area, with satellite image analysis and software simulation, detailed studies were made on the evolution process of the shoreline, the stability of the shoreline and the sediment level in the last 20 years. On this basis, the conceptual model of sediment transport is presented, and the coastal dune can be used as a transport engine to drive sediment migration between coastal cells and maintain the stable development of the coastal area. Under the same dynamic conditions, once the engine is turned off, such as forest replacing natural coastal dunes, the sediment transport path is blocked, which will cause accretion of the upstream flank and erosion of the downstream flank. Human beings tend to change the natural environment for their own interests, and the feedback mechanism of the natural environment is often characterized by hysteresis effect, which is not worth the loss in the long run. We should respect nature and reduce unnecessary environmental damage.
Lactational exposure of human infants to metal (loid)s: A comparison of industrial and urban inhabitants in north of the Persian Gulf
Authors: Amiri Leila , Doroodzani Atefeh Khalili , Ostovar Afshin , Dobaradaran Sina , Mohammadi Azam , Nabipour Iraj , Raeisi Alireza , Malekizadeh Hasan , Farhadi Akram , Saeedi Reza , Afrashteh Sima , Nazmara Shahrokh , Keshtkar Mozhgan 
Published: March 2023

Abstract
In this study, postnatal metal (loid)s (MLs) exposure was compared between the petrochemical and gas area of Asaluyeh (PGA) and urban area of Kaki (UA) in Bushehr province, Iran. Two hundred human breast milk (BM) samples from the industrial and urban areas were analyzed for MLs using Inductivity Coupled Plasma-Optical Emission Spectrometry (ICP-OES). Boron (B), cooper (Cu), iron (Fe), and nickel (Ni) were found at the highest levels in both study areas. Adjusted multiple linear regression models revealed that the mean concentration of total MLs in BM samples collected from the PGA was statistically significantly greater than that of the UA (655.85 vs. 338.17 µg/L). Also, the mean concentrations of all detected MLs in BM samples collected from the PGA were statistically significantly higher than those collected from the UA. The hazard index (HI) of combined MLs in the PGA and UA illustrated non-cancer risk for infants. Lead (Pb) and chromium (Cr) in the PGA and Cr in the UA showed the risk of cancer. So it can be concluded that nursing infants from an industrial area are most at risk for MLs exposure during entire lactation course than those from an urban area.
Kaempferol attenuates gouty arthritis by regulating the balance of Th17/Treg cells and secretion of IL-17
Authors: Li Nan , Chen Shulin , Deng Weiqing , Gong Zhaohui , Zeng Shan , Guo Yu , Xu Qiang 
Published: March 2023

Abstract
Background
Kaempferol is a common flavonoid aglycone widely found in plants. It exhibits beneficial therapeutic effects in the treatment of arthritis. However, the effects of kaempferol on gouty arthritis (GA) have not been verified. This study aimed to explore the potential mechanisms by which kaempferol regulates GA by network pharmacology and experimental validation.
Methods
Potential drug targets for GA were identified with a protein–protein interaction network. Then, we performed a KEGG pathway analysis to elucidate the major pathway involved in the kaempferol-mediated treatment of GA. In addition, the molecular docking was performed. A rat model of GA was constructed to verify the results of network pharmacology analysis and investigate the mechanism of kaempferol against GA.
Results
The network pharmacology study indicated that there were 275 common targets of kaempferol and GA treatment. Kaempferol exerted therapeutic effects on GA, in part, by regulating the IL-17, AGE-RAGE, p53, TNF, and FoxO signalling pathways. Molecular docking results showed that kaempferol stably docked with the core MMP9, ALB, CASP3, TNF, VEGFA, CCL2, CXCL8, AKT1, JUN and INS. Experimental validation suggested that kaempferol eased MSU-induced mechanical allodynia, ankle oedema and inflammation. It significantly suppressed the expression of IL-1β, IL-6, TNF-α, and TGF-β1. Kaempferol also restored IL-6-induced Th17/Treg imbalance and affected RORγt and Foxp3 through IL-17 pathway.
Conclusion
The present study clarifies the mechanism of kaempferol against GA and provides evidence to support its clinical use.
Road mortality of water snakes in active versus protected floodplains in light of landscape structure and traffic volume in north-eastern Hungary
Authors: Szabolcs Márton , Mizsei Edvárd , Zsólyomi Tamás , Mester Béla , Lengyel Szabolcs 
Published: March 2023

Abstract
Flood protection measures can have large impacts on ecosystems and their biodiversity, yet direct comparisons of active and inactive floodplains are rare. We compared the number of roadkilled individuals of two semiaquatic water snakes (Natrix natrix and N. tessellata) on 58 km of road sections bordered either by an active floodplain or a flood-protected former floodplain in NE Hungary based on surveys conducted once every two weeks in three years. We found unexpectedly high road mortality of snakes, which was rather similar across years. Mortality had a spring and an autumn peak, corresponding to the times when snakes emerge from and return to hibernating sites. Road mortality was more severe and more predictable in the flooded than in the flood-protected area, even though traffic was more intense in the latter. Our results show that small-scale spatial differences in road mortality are mediated by landscape structure along the road, while the effects of traffic intensity and the age and sex of the individuals were negligible. For conservation implications, our study suggests that establishing culvert passages under the road and artificial hibernating sites on the floodplain-side of the roads in critical sections to reduce the road-related mortality.
Effect of multimedia teaching tools in parental anxiety and comprehension of informed consent procedure in pediatric surgical procedures
Authors: Shreyas K , Jadhav Avinash , Goel Akhil , Pathak Manish , Nayak Shubhalaxmi , Rathod Kirtikumar , Saxena Rahul , Sinha Arvind 
Published: March 2023

Abstract
Introduction: Informed consent is an essential component of medical ethics. A number of adjuncts have been developed to supplement the consent process, which includes informational pamphlets, and multimedia tools such as interactive apps and videos. Unfortunately, there is little information regarding the use of Multimedia tools in pediatric settings in the developing world. The purpose of this study was to measure the impact of Multimedia tool-assisted versus the conventional consenting method on parental anxiety and their comprehension of surgical procedures.
Methods: A randomized control trial was conducted between 2018-2020, including MMT and conventional groups. A novel Multimedia tool with Microsoft PowerPoint presentation was created. A 5-Question knowledge-based test, State-Trait Anxiety Inventory (STAI) tool, and a Likert-based questionnaire were used to assess the comprehension, anxiety, and satisfaction of parents.
Results: Among 122 randomized cohorts, the mean value of percentage fall in anxiety STAI score in the MMT group was 44.64 ± 10.14 whereas in the Conventional group it was 26.6 ± 11.91 (p<0.05). MMT cohort scored higher in the knowledge-based test (p<0.05) and recorded higher parental satisfaction.
Conclusion: The Multimedia tool aided consent procedure is effective in reducing parental anxiety and improving their comprehension and overall satisfaction. Thus, they can be used as an effective supplement in preoperative surgical education and consent procedure.
HRAS (Harvey rat sarcoma proto-oncogene), the prognostic cancer biomarker: Phylogenetic and proteomic analyses across 32 primates
Authors: Lim Leonard Whye Kit 
Published: March 2023

Abstract
HRAS protein is indispensable cell division regulator, mutated HRAS gene can lead to unregulated cell growth and subsequently cause cancer. In this study, we assembled all 32 complete primate HRAS proteins from the public GenBank database and further characterized them from phylogenetic and proteomic angles. The New World primate HRAS proteins were unravelled to be very greatly conserved in terms of amino acid length, molecular weight and isoelectric point. Motif distribution and predicted protein modelling of all primate HRAS proteins exhibited non-distinctive features. The maximum likelihood phylogenetic tree unearthed two main clades, with seven protein members housing the minor clade. The data produced from this study can channel clues to combat HRAS-related cancers in the future.
Study of the influence of thermobaric conditions on the rheological characteristics of plugging solutions for insulation works
Authors: Sudaba Novruzova , Aliyev Inglab , Ahmad Fariz 
Published: March 2023

Since most of the fields in the Absheron peninsula of the Republic of Azerbaijan are at the final stage of development, an inevitable reduction in hydrocarbon production is expected. An increase in the proportion of formation water in well production, the presence of intra-reservoir, annulus and other cross-flows in this region, in most cases, is associated with inefficient isolation work.
The development of effective recipes for cement slurries with controlled rheological properties is relevant. Natural zeolite was used as an additive to control the rheological properties of cement slurries. A feature of zeolites is the presence of a system of regular channels and communicating cavities capable of holding ions, atoms and molecules of substances, whose size corresponds to the size of free space.
Zeolite (clinoptilolite) has the following properties: adsorption ‒ the ability to absorb and release various substances; ion exchange ‒ the ability to exchange cations; catalytic ‒ the ability to speed up chemical reactions. In addition, clinoptilolite has a molecular sieve effect that transmits (filtration) and absorbs molecules of various substances selectively. In the course of experiments, the effects of zeolite dispersions on the physicochemical parameters of cement stone were studied. When regulating the rheological properties of cement slurries with zeolite additives, it is necessary to determine the effect of thermobaric factors on the values of these properties. In studies to assess the effect of temperature on the rheological properties of zeolite-cement mortars, they were carried out for the temperature range of 25÷75 ℃
Characterization of Influenza-Like Illness Burden Using Commercial Wearable Sensor Data and Patient-Reported Outcomes: Mixed Methods Cohort Study
Authors: Hunter Victoria , Shapiro Allison , Chawla Devika , Drawnel Faye , Ramirez Ernesto , Phillips Elizabeth , Tadesse-Bell Sara , Foschini Luca , Ukachukwu Vincent 
Published: March 2023

Background
The burden of influenza-like illness (ILI) is typically estimated via hospitalizations and deaths. However, ILI-associated morbidity that does not require hospitalization remains poorly characterized.

Objective
The main objective of this study was to characterize ILI burden using commercial wearable sensor data and investigate the extent to which these data correlate with self-reported illness severity and duration. Furthermore, we aimed to determine whether ILI-associated changes in wearable sensor data differed between care-seeking and non–care-seeking populations as well as between those with confirmed influenza infection and those with ILI symptoms only.

Methods
This study comprised participants enrolled in either the FluStudy2020 or the Home Testing of Respiratory Illness (HTRI) study; both studies were similar in design and conducted between December 2019 and October 2020 in the United States. The participants self-reported ILI-related symptoms and health care–seeking behaviors via daily, biweekly, and monthly surveys. Wearable sensor data were recorded for 120 and 150 days for FluStudy2020 and HTRI, respectively. The following features were assessed: total daily steps, active time (time spent with >50 steps per minute), sleep duration, sleep efficiency, and resting heart rate. ILI-related changes in wearable sensor data were compared between the participants who sought health care and those who did not and between the participants who tested positive for influenza and those with symptoms only. Correlative analyses were performed between wearable sensor data and patient-reported outcomes.

Results
After combining the FluStudy2020 and HTRI data sets, the final ILI population comprised 2435 participants. Compared with healthy days (baseline), the participants with ILI exhibited significantly reduced total daily steps, active time, and sleep efficiency as well as increased sleep duration and resting heart rate. Deviations from baseline typically began before symptom onset and were greater in the participants who sought health care than in those who did not and greater in the participants who tested positive for influenza than in those with symptoms only. During an ILI event, changes in wearable sensor data consistently varied with those in patient-reported outcomes.

Conclusions
Our results underscore the potential of wearable sensors to discriminate not only between individuals with and without influenza infections but also between care-seeking and non–care-seeking populations, which may have future application in health care resource planning.

Trial Registration
Clinicaltrials.gov NCT04245800; https://clinicaltrials.gov/ct2/show/NCT04245800
Racial/Ethnic Disparity in Association Between Fetal Alcohol Syndrome and Alcohol Intake During Pregnancy: Multisite Retrospective Cohort Study
Authors: Oh Sarah Soyeon , Kang Bada , Park Jewel , Kim SangMin , Park Eun-Cheol , Lee Seung Hee , Kawachi Ichiro 
Published: March 2023

Background
Alcohol consumption during pregnancy is associated with a range of adverse birth-related outcomes, including stillbirth, low birth weight, preterm birth, and fetal alcohol syndrome (FAS). With more than 10% of women consuming alcohol during pregnancy worldwide, it is increasingly important to understand how racial/ethnic variations affect FAS onset. However, whether race and ethnicity inform FAS risk assessment when daily ethanol intake is controlled for remains unknown.

Objective
This study aimed to assess racial/ethnic disparities in FAS risk associated with alcohol consumption during pregnancy.

Methods
We used data from a longitudinal cohort study (the Collaborative Initiative on Fetal Alcohol Spectrum Disorders) at 5 hospital sites around the United States of 595 women who consumed alcohol during pregnancy from 2007 to 2017. Questionnaires, in-person interviews, and reviews of medical, legal, and social service records were used to gather data on average alcoholic content (AAC) during pregnancy. Self-reports of maternal race (American Indian/Alaska Native [AI/AN], Asian, Native Hawaiian or other Pacific Islander, Black or African American, White, more than one race, and other) and ethnicity (Hispanic/Latino or not Hispanic/Latino), as well as FAS diagnoses based on standardized dysmorphological criteria, were used for analysis. Log-binomial regression was used to examine the risk of FAS associated with each 1-gram increase in ethanol consumption during pregnancy, stratified by race/ethnicity.

Results
A total of 3.4% (20/595) of women who reported consuming alcohol during pregnancy gave birth to a baby with FAS. Women who gave birth to a baby with FAS had a mean AAC of 32.06 (SD 9.09) grams, which was higher than that of women who did not give birth to a baby with FAS (mean 12.07, SD 15.87 grams). AI/AN mothers with FAS babies had the highest AAC (mean 42.62, SD 8.35 grams), followed by White (mean 30.13, SD 4.88 grams) and Black mothers (mean 27.05, SD 12.78 grams). White (prevalence ratio [PR] 1.10, 95% CI 1.03-1.19), Black (PR 1.13, 95% CI 1.04-1.23), and AI/AN (PR 1.10, 95% CI 1.00-1.21) mothers had 10% to 13% increased odds of giving birth to a baby with FAS given the same exposure to alcohol during pregnancy. Regardless of race, a 1-gram increase in AAC resulted in a 4% increase (PR 1.04, 95% CI 1.02-1.07) in the chance of giving birth to a baby with ≥2 facial anomalies (ie, short palpebral fissures, thin vermilion border of the upper lip, and smooth philtrum) and a 4% increase (PR 1.04, 95% CI 1.01-1.07) in the chance of deficient brain growth.

Conclusions
The risk of delivering a baby with FAS was comparable among White, Black, and AI/AN women at similar levels of drinking during pregnancy. Regardless of race, a 1-gram increase in AAC resulted in increased odds of giving birth to a baby with facial anomalies or deficient brain growth.
On the Rule and the Use of Precedents: Brief Comments on the Works of Fabio Pulido Ortiz and Silvia Zorzetto
Authors: Núñez Álvaro 
Published: March 2023

It filled me with pleasure to be asked by Problema editor-in-chief Sandra Gómora Juárez to lead a discussion on the theories and doctrine on precedent in our context alongside Prof. Marina Gascón Abellán. Besides the undeniable and recognized prestige of the Problema journal, there was also the possibility of working with Prof. Marina Gascón again and with Sandra Gómora for the first time. It was also an opportunity to discuss issues regarding precedent with old friends like Flavia Carbonell, Fabio Pulido and Silvia Zorzetto, and exchange opinions with new ones like Rodrigo Camarena. On this occasion, I would like to comment specifically on the works of Prof. Fabio Pulido Ortiz and Prof. Silvia Zorzetto, both of which are of unquestionable quality. The article by Prof. Pulido Ortiz of the Universidad de la Sabana in Colombia is a work of analytical finesse and subtlety that discusses some fundamental problems of legal theory from the standpoint of the theory of precedent. Prof. Silvia Zorzetto from Università Statale di Milano has conducted an analytical and metalinguistic survey of the use of precedents in Italy, particularly at the Italian Sezioni Unite Civili della Corte di Cassazione. This work is priceless not only in terms of its value as a study of (internal) Italian legal culture, but also because the analysis can be generalized, at least in part, to explain how precedents are used in civil law systems.
Stages of evolution of the Glinka manor near Moscow, developed by Ya.V. Bruce on the basis of historical, architectural and field studies
Authors: Chekmaryov Vladimir M. 
Published: March 2023

Introduction. The purpose of this article is to consider the gradual evolution of a unique manor in the Moscow region,
consolidated by Ya.V. Bruce, a famous statesman and scientist of the Peter the Great era. It is located 42 km from Moscow
in the immediate vicinity of Losino-Petrovsky, north of the village of Corpus and the Vorya river. Being an item of cultural
heritage of federal significance, this manor underwent a number of structural changes, which affected both its original layout
and spatial structure. The purpose of the study is to clarify the history of the manor and to trace the main stages of its
transformation from the middle of the 18th century to the present time. In this regard, it was particularly important to clarify
the initial (basic) structure of its layout by tracing the original idea of Ya.V. Bruce, the customer. The issue of original architectural
solution is also fundamental.
Materials and methods. The study of the establishment and further transformation of the manor is based on the method
of consolidated studies of the sources, which includes a search for and analysis of archived and bibliographic sources. Field
studies were accompanied by the in-depth study of the entire territory of the monument, its topography, water bodies and
landscaping, as well as the architectural features of its buildings.
Results. The construction periodization of the monument was identified; dates of construction of buildings in this territory,
including their late reconstruction, were clarified to identify the main stages in the manor development to draft a detailed
project of its consolidated research-based restoration.
Conclusions. Analysis of the evolution of the manor led to the clarification of its original look, taking into account structural
changes in the elements of its development, to complement the information about the manor culture of the 1st half of the 18th
century. It also clarifies the intentions of the customer, an extraordinary person of the Peter the Great era.
El artefacto del relato. Conferencia de Nicole d'Almeida
Authors: Giaimo Mariangela 
Published: March 2023

Las narraciones crean y reproducen la cultura de una comunidad y su lazo social. Este artículo recupera una conferencia dictada por Nicole d ́Almeida en la Universidad Católica del Uruguay, en la cual la autora problematiza el análisis del relato a través de la presentación de una tipología y un acercamiento metodológico a él.Este texto surge de la conferencia “Relatos de exclusión e inclusión” que Nicole d'Almeida presentó el viernes 31 de octubre de 2008 en la Universidad Católica. Esta conferencia formó parte de la “Semana sobre los procesos sociales de exclusión e inclusión”, organizada por la Embajada de Francia en el Uruguay, la Universidad Católica, la Universidad de la República, el Instituto Universitario CLAEH y el Polo Mercosur. El texto fue recuperado por Mariangela Giaimo, a partir de la traducción de la Prof. Ana Guarnerio.