bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Appeals Chamber’s Jurisdictional Judgment in Abd-Al-Rahman and the Issue of Applicable Law at the International Criminal Court
Authors: Lemos Miguel 
Published: July 2023

Abstract
On 1 November 2021, the Appeals Chamber of the ICC upheld the notion that, depending on the type of case over which the court exercises jurisdiction, it must use two different bodies of substantive law to evaluate whether certain conduct is criminal and, hence, whether the court has the power to prosecute and convict individuals for such conduct. This contribution argues that this bifurcation in the substantive law applicable at the ICC leads to disconcerting results, no sound normative principle supports it, and it does not correspond to the design of the creators of the court.
Management of patients on antithrombotic therapy with severe infections: a joint clinical consensus statement of the ESC Working Group on Thrombosis, the ESC Working Group on Atherosclerosis and Vascular Biology, and the International Society on Thrombosis and Haemostasis
Authors: Gigante Bruna , Levy Jerrold H , van Gorp Eric , Bartoloni Alessandro , Bochaton-Piallat Marie-Luce , Bäck Magnus , ten Cate Hugo , Christersson Christina , Ferreiro José Luis , Geisler Tobias , Lutgens Esther , Schulman Sam , Storey Robert F , Thachil Jecko , Vilahur Gemma , Liaw Patricia C , Rocca Bianca 
Published: July 2023

Abstract
Patients with severe infections and a pre-existing indication for antithrombotic therapy, i.e. antiplatelet agents, anticoagulant drugs, or their combinations, require integrated clinical counselling among coagulation, infectious disease, and cardiology specialists, due to sepsis-induced coagulopathy that frequently occurs. Bacterial and viral pathogens constitute an increasing threat to global public health, especially for patients with ongoing antithrombotic treatment who have a high risk of thrombotic recurrences and high susceptibility to severe infections with increased morbidity and mortality. Similarly, sepsis survivors are at increased risk for major vascular events. Coagulopathy, which often complicates severe infections, is associated with a high mortality and obligates clinicians to adjust antithrombotic drug type and dosing to avoid bleeding while preventing thrombotic complications. This clinical consensus statement reviews the best available evidence to provide expert opinion and statements on the management of patients hospitalized for severe bacterial or viral infections with a pre-existing indication for antithrombotic therapy (single or combined), in whom sepsis-induced coagulopathy is often observed. Balancing the risk of thrombosis and bleeding in these patients and preventing infections with vaccines, if available, are crucial to prevent events or improve outcomes and prognosis.
Faecalibacterium: a bacterial genus with promising human health applications
Authors: Martín Rebeca , Rios-Covian David , Huillet Eugénie , Auger Sandrine , Khazaal Sarah , Bermúdez-Humarán Luis G , Sokol Harry , Chatel Jean-Marc , Langella Philippe 
Published: July 2023

AbstractIn humans, many diseases are associated with alterations in gut microbiota, namely increases or decreases in the abundance of specific bacterial groups. One example is the genus Faecalibacterium. Numerous studies have underscored that low levels of Faecalibacterium are correlated with inflammatory conditions, with inflammatory bowel disease (IBD) in the forefront. Its representation is also diminished in the case of several diseases, including colorectal cancer (CRC), dermatitis, and depression. Additionally, the relative presence of this genus is considered to reflect, at least in part, intestinal health status because Faecalibacterium is frequently present at reduced levels in individuals with gastrointestinal diseases or disorders. In this review, we first thoroughly describe updates to the taxonomy of Faecalibacterium, which has transformed a single-species taxon to a multispecies taxon over the last decade. We then explore the links discovered between Faecalibacterium abundance and various diseases since the first IBD-focused studies were published. Next, we examine current available strategies for modulating Faecalibacterium levels in the gut. Finally, we summarize the mechanisms underlying the beneficial effects that have been attributed to this genus. Together, epidemiological and experimental data strongly support the use of Faecalibacterium as a next-generation probiotic (NGP) or live biotherapeutic product (LBP).
Financial Self-Efficacy, Retirement Goal Clarity, and Pre-retirement Anxiety among Nurses in Southeast, Nigeria: The Mediating Role of Job Embeddedness
Authors: Ujoatuonu Ikechukwu V N , Ike Obinna O , Amazue Lawrence O , Kanu Gabriel C 
Published: July 2023

Abstract

Background and Objectives
It has been evidenced that retirement transitions are accompanied by pre-retirement anxiety about transitioning from a work-oriented lifestyle to retirement. Most employees do not proactively address these concerns during this transitional period. Thus, identifying the factors inherent in pre-retirement anxiety is imperative for a positive retirement transition. This study explored the role of financial self-efficacy and pre-retirement goal clarity on pre-retirement anxiety and the mediating role of job embeddedness in such relationships among prospective retiree nurses in Sub-Saharan Africa.

Research Design and Methods
This cross-sectional study used self-report measures of the Pre-retirement Anxiety scale, Financial Self-Efficacy Scale, Retirement Goal Clarity Scale, and Job Embeddedness Scale for data collection. A total of 236 nurses participated in the study. Descriptive analyses were done to determine the bivariate correlations among the study variables, while regression-based path analysis was carried out to test the hypotheses.

Results
Results revealed that goal clarity and financial self-efficacy showed a strong negative association with pre-retirement anxiety. Also, higher job embeddedness was negatively associated with pre-retirement anxiety. In addition, there was a significant indirect relationship between financial self-efficacy and pre-retirement anxiety, as well as pre-retirement goal clarity and pre-retirement anxiety through job embeddedness. Hence, the influence of financial self-efficacy and pre-retirement goal clarity on pre-retirement anxiety was mediated by job embeddedness.

Discussion and Implication
The results emphasised that financial self-efficacy and pre-retirement planning are imperative for a positive perception towards retirement transition. In addition, job embeddedness should be encouraged among employees because it facilitates connectedness and interrelatedness in social fusion, ideas, and projections towards retirement transition. This connotes that the development of attachment to place and the formation of strong social ties are sacrosanct for retirement transition. These results are crucial for developing a methodology for support services for prospective employees in retirement transition.
Predictors of Multiwave Opioid Use Among Older American Adults
Authors: Fennell Gillian , Jacobson Mireille , Grol-Prokopczyk Hanna 
Published: July 2023

Abstract

Background and Objectives
Despite limited analgesic benefits, long-term opioid therapy (L-TOT) is common among older adults with chronic pain. Extended opioid use poses a threat to older adults as aging metabolisms retain opioids for longer, increasing the risk of injury, overdose, and other negative health outcomes. In contrast to predictors of general opioid use, predictors of L-TOT in older adults are not well documented. We aimed to identify such predictors using all available data on self-reported opioid use in the Health and Retirement Study.

Research Design and Methods
Using 5 waves of data, respondents (N = 10,713) aged 51 and older were identified as reporting no opioid use (n = 8,621), a single wave of use (n = 1,410), or multiple waves of use (n = 682). We conducted a multinomial logistic regression to predict both single- and multiwave opioid use relative to no use. Demographic, socioeconomic, geographic, health, and health care–related factors were included in our model.

Results
Multivariable findings show that, relative to nonusers, both single- and multiwave users were significantly more likely to be younger (relative risk ratio [RRR] = 1.33; RRR = 2.88); report lower household wealth (RRR = 1.47; RRR = 2.88); live in the U.S. Midwest (RRR = 1.29; RRR = 1.56), South (RRR = 1.34; RRR = 1.58), or West (RRR = 1.46; RRR = 2.34); experience interfering pain (RRR = 1.59; RRR = 3.39), back pain (RRR = 1.35; RRR = 1.53), or arthritic pain (RRR = 1.46; RRR = 2.32); and see the doctor frequently (RRR = 1.50; RRR = 2.02). Multiwave users were less likely to be Black (RRR = 0.69) or Hispanic (RRR = 0.45), and less likely to be never married (RRR = 0.52).

Discussion and Implications
We identified demographic, socioeconomic, geographic, and health care-related predictors of chronic multiyear opioid use. Our focus on individuals taking opioids for this extended duration is novel. Differences in opioid use by geographic region and frequency of doctor visits particularly warrant attention from policy-makers and researchers. We make additional recommendations based on a sensitivity analysis limited to 2016–2020 data.
The Effectiveness and Characteristics of Communication Partner Training Programs for Families of People With Dementia: A Systematic Review
Authors: Folder Naomi , Power Emma , Rietdijk Rachael , Christensen Iben , Togher Leanne , Parker Deborah 
Published: July 2023

Abstract

Background and Objectives
Communication partner training (CPT) is essential in dementia care. Despite families being the largest group of community carers, previous reviews primarily focused on formal carers. This study aimed to understand the characteristics and effectiveness of CPT for families of people with dementia.

Research Design and Methods
The systematic review included intervention/protocol studies on dementia CPT for families, excluding formal carers and programs not focused on communication. CINAHL, PsycINFO, SpeechBITE, Medline, SCOPUS, and Embase were searched between November 30 and December 6, 2021. After deduplication, 3,172 records were screened. Quality assessment used JBI Critical Appraisal tools and the Mixed Methods Appraisal Tool. Data synthesis utilized three reporting tools, the International Classification of Functioning, Disability, and Health, and content analysis.

Results
Of 30 studies (27 programs), there were 10 quasi-experimental, 5 RCTs, 4 mixed methods, 4 case studies, 4 qualitative, and 2 protocols. Studies were published between 1998 and 2021 and included 671 family members. Characteristics varied with 7/27 programs including consumers during creation and one program including telehealth. One study included all reporting tool criteria. Programs typically used 4 intervention functions, with 12/27 programs addressing 3 behavior change areas. 33/74 outcome measures targeted the “Environment” of the person with dementia. Studies showed positive improvements in communication skills and knowledge, with mixed results on behavior/psychosocial outcomes. Qualitative results identified improvements in conversation and attitudes.

Discussion and Implications
CPT for families improves communication outcomes, however, quality of studies varied significantly. Future research should address gaps in telehealth, consumer involvement, and intervention descriptions.
A numerical assessment of local strain measurements on the attenuation and modulus dispersion in rocks with fluid heterogeneities
Authors: Sun Chao , Tang Genyan , Chapman Samuel , Zhang Huai , Fortin Jérôme , Wang Shangxu , Pan Dongming , Yue Jianhua 
Published: July 2023

SUMMARY
The forced oscillation method is widely used to investigate intrinsic seismic wave dispersion and attenuation in rock samples by measuring their dynamic stress–strain response. However, using strain gauges to locally measure the strains on samples surfaces can result in errors in determining the attenuation and moduli of rocks with mesoscopic scale heterogeneities. In this study, we developed a 3-D numerical model based on Biot's poroelastic theory to investigate the effect of strain gauge location, number and size on attenuation and dispersion in response to wave-induced fluid flow. Our results show that increasing the strain gauge length, number, and size can reduce the error between local and bulk responses. In a homogeneous and isotropic rock with a quasi-fractal fluid heterogeneity at 12 per cent gas saturation, the relative error between local and bulk responses stays below 6 per cent when the strain gauge length surpasses 8.6 times the correlation length. As the gas saturation becomes larger, the ratio minimally changes non-monotonically, initially increasing and then decreasing. We also used the Monte Carlo method to demonstrate that local laboratory measurements can approximate the reservoir-scale response with a minimum relative error of 1.5 per cent as the sample number increases. Our findings provide guidance for (i) interpreting local low-frequency measurements in terms of bulk properties of rock and (ii) upscaling lab measurements to reservoir-scale properties.
Do health service waiting areas contribute to the health literacy of consumers? A scoping review
Authors: McDonald Cassie E , Voutier Catherine , Govil Dhruv , D’Souza Aruska N , Truong Dominic , Abo Shaza , Remedios Louisa J , Granger Catherine L 
Published: July 2023

Abstract
Health service waiting areas commonly provide health information, resources and supports for consumers; however, the effect on health literacy and related outcomes remains unclear. This scoping review of the literature aimed to explore the use of waiting areas as a place to contribute to the health literacy and related outcomes of consumers attending health appointments. Articles were included if they focussed on health literacy or health literacy responsiveness (concept) in outpatient or primary care health service waiting areas (context) for adult consumers (population) and were published after 2010. Ten bibliographic databases, one full-text archive, dissertation repositories and web sources were searched. The search yielded 5095 records. After duplicate removal, 3942 title/abstract records were screened and 360 full-text records assessed. Data were charted into a standardized data extraction tool. A total of 116 unique articles (published empirical and grey literature) were included. Most articles were set in primary and community care (49%) waiting areas. A diverse range of health topics and resource types were available, but results demonstrated they were not always used by consumers. Outcomes measured in intervention studies were health knowledge, intentions and other psychological factors, self-reported and observed behaviours, clinical outcomes and health service utilization. Intervention studies overall demonstrated positive trends in health literacy-related outcomes, although the benefit declined after 3–6 months. Research on using waiting areas for health literacy purposes is increasing globally. Future research investigating the needs of consumers to inform optimal intervention design is needed.
Pomegranate sarcotesta lectin (PgTeL) inhibits planktonic growth and disrupts biofilm formed by Cryptococcus neoformans
Authors: Ferreira Gustavo Ramos Salles , da Silva Pollyanna Michelle , Lopes William , Feitosa Ana Paula Sampaio , Coelho Luana Cassandra Breitenbach Barroso , Brayner Fábio André , Alves Luiz Carlos , Paiva Patrícia Maria Guedes , de Moura Maiara Celine , Vainstein Marilene Henning , Napoleão Thiago Henrique 
Published: July 2023

Abstract

Aims
We investigated the putative fungistatic and fungicidal activities of pomegranate sarcotesta lectin (PgTeL) against Cryptococcus neoformans B3501 (serotype D), specifically the ability of PgTeL to inhibit yeast capsule and biofilm formation in this strain.

Methods and results
PgTeL showed a minimum inhibitory concentration of 172.0 μg ml−1, at which it did not exhibit a fungicidal effect. PgTeL concentrations of 4.0–256.0 μg ml−1 reduced biofilm biomass by 31.0%–64.0%. Furthermore, 32.0–256.0 μg ml−1 PgTeL decreased the metabolic activity of the biofilm by 32.0%–93.0%. Scanning electron microscopy images clearly revealed disruption of the biofilm matrix. Moreover, PgTeL disrupted preformed biofilms. At concentrations of 8.0–256.0 μg ml−1, PgTeL reduced metabolic activity in C. neoformans by 36.0%–92.0%. However, PgTeL did not inhibit the ability of B3501 cells to form capsules under stress conditions.

Conclusions
PgTeL inhibited biofilm formation and disrupted preformed biofilms, demonstrating its potential for use as an anticryptococcal agent.
A novel method to create realistic synthetic medication data
Authors: Hodges Robert , Tokunaga Kristen , LeGrand Joseph 
Published: July 2023

Abstract

Objective
Synthea is a synthetic patient generator that creates synthetic medical records, including medication profiles. Prior to our work, Synthea produced unrealistic medication data that did not accurately reflect prescribing patterns. This project aimed to create an open-source synthetic medication database that could integrate with Synthea to create realistic patient medication profiles.

Materials and Methods
The Medication Diversification Tool (MDT) created from this study combines publicly available prescription data from the Medical Expenditure Panel Survey (MEPS) and standard medication terminology/classifications from RxNorm/RxClass to produce machine-readable information about medication use in the United States.

Results
The MDT was validated using a chi-square goodness-of-fit test by comparing medication distributions from Synthea, Synthea+MDT, and the MEPS. Using a pediatric asthma population, results show that Synthea+MDT had no statistical difference compared to the real-world MEPS with a P value = .84.

Discussion
The MDT is designed to generate realistic medication distributions for drugs and populations. This tool can be used to enhance medication records generated by Synthea by calculating medication-use data at a national level or specific to patient subpopulations. MDT’s contributions to synthetic data may enable the acceleration of application development, access to more realistic healthcare datasets for education, and patient-centered outcomes’ research.

Conclusions
The MDT, when used with Synthea, provides a free and open-source method for making synthetic patient medication profiles that mimic the real world.
Senso-immunology: the past, present, and future
Authors: Miyamoto Satoshi , Kondo Takeshi , Maruyama Kenta 
Published: July 2023

Abstract
Pain and mechanical stimulation are thought to be alarm systems that alert the brain to physical abnormalities. When we experience unpleasant feelings in infected or traumatized tissues, our awareness is directed to the afflicted region, prompting activities such as resting or licking the tissue. Despite extensive research into the molecular biology of nociceptors, it was unclear whether their role was limited to the generation and transmission of unpleasant feelings or whether they actively modulate the pathogenesis of infected or traumatized tissues. Recently, it has become clear how the sensory and immune systems interact with one another and share similar receptors and ligands to modify the pathogenesis of various diseases. In this paper, we summarize the mechanisms of crosstalk between the sensory and immune systems and the impact of this new interdisciplinary field, which should be dubbed ‘senso-immunology,’ on medical science.
Resistance againstLeucoptera sinuella(Lepidoptera: Lyonetiidae) among hybrid clones ofPopulusspp. in central Chile
Authors: Yánez-Segovia Sebastián , Ramírez Claudio C , Lindroth Richard L , Fuentes-Contreras Eduardo 
Published: July 2023

AbstractLeucoptera sinuella (Reutti) (Lepidoptera: Lyonetiidae) is a leaf miner specialist on Salicaceae recently introduced to Chile and Argentina, where it is causing economic damage to poplar plantations. We report a field survey in a poplar nursery naturally infested showing that regardless of the poplar hybrid taxon, high variability in resistance was observed among clones within families for oviposition and leaf-mining damage. A group of susceptible and resistant hybrid poplar clones was then selected for a laboratory evaluation of oviposition (antixenosis) and leaf-mining damage (antibiosis) on potted, rooted shoot cuttings. The concentration of condensed tannins (CTs) and salicinoid phenolic glucosides (SPGs) of the leaves of the selected clones from the laboratory study was also measured. Total oviposited eggs were positively correlated with leaf area, with the lowest oviposition on TMxT 11372 clone. The lowest percentage of mined leaf area was obtained for clones TMxT 11372, TMxT 11463, and TDxD 17574, but surprisingly no correlation between the percentage of mined leaf area and concentration of CTs and SPGs was found. Resistant poplar hybrids of our study could be suitable for breeding programs aimed for L. sinuella integrated pest management.
Expression of TMEM59L associated with radiosensitive in glioblastoma
Authors: Gao Dezhi , Wang Peng , Zhi Lin , Sun Shibin , Qiu Xiaoguang , Liu Yanwei 
Published: July 2023

Abstract
Radiotherapy is one of the cornerstone of the glioblastoma treatment paradigm. However, the resistance of tumor cells to radiation results in poor survival. The mechanism of radioresistance has not been fully elucidated. This study aimed to screen the differential expressed genes related with radiosensitivity. The differentially expressed genes were screened based on RNA sequencing in 15 pairs of primary and recurrent glioblastoma that have undergone radiotherapy. Candidate genes were validated in 226 primary and 134 recurrent glioblastoma (GBM) obtained from the Chinese Glioma Genome Atlas (CGGA) database. RNA and protein expression were verified by Quantitative Real-time PCR (qPCR) and western blot in irradiated GBM cell lines. The candidate gene was investigated to explore the relationship between mRNA levels and clinical characteristics in the CGGA and The Cancer Genome Atlas dataset. Kaplan–Meier survival analysis and Cox regression analysis were used for survival analysis. Gene ontology and KEGG pathway analysis were used for bioinformatics analysis. Four genes (TMEM59L, Gelsolin, ZBTB7A and ATX) were screened. TMEM59L expression was significantly elevated in recurrent glioblastoma and lower in normal brain tissue. We selected TMEM59L as the target gene for further study. The increasing of TMEM59L expression induced by radiation was confirmed by mRNA and western blot in irradiated GBM cell. Further investigation revealed that high expression of TMEM59L was enriched in IDH mutant and MGMT methylated gliomas and associated with a better prognosis. Gene ontology and KEGG pathway analysis revealed that TMEM59L was closely related to the DNA damage repair and oxidative stress respond process. We speculated that the high expression of TMEM59L might enhance radiotherapy sensitivity by increasing ROS-induced DNA damage and inhibiting DNA damage repair process.
Hydrometrocolpos in an infant with urological complications: a rare case and review of literature
Authors: Ngowi Bartholomeo N , Bright Frank , Lodhia Jay , Kimolo Mathias , Shirima Denis , Mbwambo Jasper S , Mteta Alfred K , Mbwambo Orgeness J 
Published: July 2023

Abstract
Hydrometrocolpos is a rare congenital anomaly characterized by gross distension of the uterus and vagina with fluid, which may result in obstruction to the urine flow. The insertion of Foley catheter into the uterus can relieve the obstruction to the flow of urine and improve renal function. Herein we present a case of infant who was diagnosed with an abdominal mass and renal insufficiency that was managed by the placement of Foley catheter into the dilated uterus and the renal function recovered.