bluuebunny/crossref_metadata_2025_split huggingface dataset:
Trauma and female reproductive health across the lifecourse: motivating a research agenda for the future of women’s health
Authors: Hillcoat Alexandra , Prakash Jaya , Martin Leah , Zhang Yu , Rosa Gabriela , Tiemeier Henning , Torres Nicole , Mustieles Vicente , Adams Charleen D , Messerlian Carmen 
Published: May 2023

Abstract
The aetiology behind many female reproductive disorders is poorly studied and incompletely understood despite the prevalence of such conditions and substantial burden they impose on women’s lives. In light of evidence demonstrating a higher incidence of trauma exposure in women with many such disorders, we present a set of interlinked working hypotheses proposing relationships between traumatic events and reproductive and mental health that can define a research agenda to better understand reproductive outcomes from a trauma-informed perspective across the lifecourse. Additionally, we note the potential for racism to act as a traumatic experience, highlight the importance of considering the interaction between mental and reproductive health concerns, and propose several neuroendocrinological mechanisms by which traumatic experiences might increase the risk of adverse health outcomes in these domains. Finally, we emphasize the need for future primary research investigating the proposed pathways between traumatic experiences and adverse female reproductive outcomes.
Deployment of machine learning algorithms to predict sepsis: systematic review and application of the SALIENT clinical AI implementation framework
Authors: van der Vegt Anton H , Scott Ian A , Dermawan Krishna , Schnetler Rudolf J , Kalke Vikrant R , Lane Paul J 
Published: May 2023

Abstract

Objective
To retrieve and appraise studies of deployed artificial intelligence (AI)-based sepsis prediction algorithms using systematic methods, identify implementation barriers, enablers, and key decisions and then map these to a novel end-to-end clinical AI implementation framework.

Materials and Methods
Systematically review studies of clinically applied AI-based sepsis prediction algorithms in regard to methodological quality, deployment and evaluation methods, and outcomes. Identify contextual factors that influence implementation and map these factors to the SALIENT implementation framework.

Results
The review identified 30 articles of algorithms applied in adult hospital settings, with 5 studies reporting significantly decreased mortality post-implementation. Eight groups of algorithms were identified, each sharing a common algorithm. We identified 14 barriers, 26 enablers, and 22 decision points which were able to be mapped to the 5 stages of the SALIENT implementation framework.

Discussion
Empirical studies of deployed sepsis prediction algorithms demonstrate their potential for improving care and reducing mortality but reveal persisting gaps in existing implementation guidance. In the examined publications, key decision points reflecting real-word implementation experience could be mapped to the SALIENT framework and, as these decision points appear to be AI-task agnostic, this framework may also be applicable to non-sepsis algorithms. The mapping clarified where and when barriers, enablers, and key decisions arise within the end-to-end AI implementation process.

Conclusions
A systematic review of real-world implementation studies of sepsis prediction algorithms was used to validate an end-to-end staged implementation framework that has the ability to account for key factors that warrant attention in ensuring successful deployment, and which extends on previous AI implementation frameworks.
Height relative to body weight in nursery pigs
Authors: Kaiser Marianne , Foldager Leslie , Herskin Mette S 
Published: May 2023

Abstract
Among the physical dimensions of the pig body, the height has received limited scientific focus. During transport, however, where multideck trucks and trailers typically are used, detailed knowledge about the height of pigs is relevant. The body weight of pigs is often known, whereas height is more difficult to quantify as part of the pre-transport management of the pigs. Nursery pigs are one category of European pig production often subjected to long distance transport for further fattening some weeks after weaning. The present study aimed to determine the height of pigs from 5 to 40 kg of body weight, as well as the relation between height and body weight. The height and weight were measured for 1,614 randomly selected pigs (castrates and females) from 10 Danish pig herds balanced between the two large breeding systems, DanBred (DB) and Danish Genetics (DG). From 9 herds, data from 1,435 pigs with 2.8 to 40.6 kg body weight were used for establishing prediction equations, while pigs from the tenth herd were set aside for validation.
The study considered using 1) polynomial regressions of various order; 2) power functions; or 3) nonlinear growth curve models. Overall, the third-order polynomial with sex-specific intercept and the power function with sex-specific log-intercept were optimal for prediction. Nevertheless, for feasibility and due to only marginal sex differences, we suggest using common intercepts for prediction of height from weight. Taken together, the results of the present study present data for pig height in the interval from 5 to 40 kg body weight. Further, we suggest that a third-order polynomial or a power function can be used for pigs from at least the genetic systems DB and DG, if the pig height is to be predicted based on body weight.
Come Together: Firm Boundaries and Delegation
Authors: Alfaro Laura , Bloom Nick , Conconi Paola , Fadinger Harald , Legros Patrick , Newman Andrew F , Sadun Raffaella , Van Reenen John 
Published: May 2023

Abstract
We jointly study firm boundaries and the allocation of decision rights within them by confronting an incomplete-contracts model with data on vertical integration and delegation for thousands of firms around the world. Integration has an option value: it confers authority to delegate or centralize decision rights, depending on who can best solve problems that arise in the course of an uncertain production process. In line with the model’s predictions, we find that firms are more likely to integrate suppliers that produce more valuable inputs and operate in industries with more dispersed productivity, and that firms delegate more decisions to integrated suppliers that produce more valuable inputs and operate in more productive industries.
A Sufi conception of order: Ibn ʿArabī’s discourse on governance
Authors: Hemida Doha Tazi 
Published: May 2023

Abstract
This article outlines, through a reading of Muḥyī al-Dīn Ibn ʿArabī’s Tadbīrāt al-ilāhiyya fī iṣlāḥ al-mamlaka al-insāniyya (Divine governance in the improvement of the kingdom of the self), a Sufi conception of order that encompasses a discourse on political governance and cuts across the realms of the cosmos, the self, and the polity. It explores the isomorphic relation and mutual ‘folding’ linking the governance of the worldly realm with that of the soul. In contrast to Montesquieu’s scheme of the ‘countervailing passions’, governance at both levels is built on the Sufi notion of ‘struggle against the self (jihād al-nafs)’ and on a theory of the human being as a microcosm. Within Ibn ʿArabī’s system, the political order is not an autonomous domain with its own rationality as developed by early modern European theorists of reason of state. A single rationality guides the governance of the microcosm and the macrocosm.
Molecular and geographic evaluations of the Heteromys pictus–spectabilis species complex indicate multiple cryptic species
Authors: Bateman Joanna , Vance Victoria A , Rogers Duke S 
Published: May 2023

Abstract
The Heteromys pictus–spectabilis species complex currently consists of two species: H. pictus, which is distributed across western, central, and southern Mexico; and H. spectabilis, an endangered species which is restricted to a small region of southeastern Jalisco. Previous phylogenetic studies have indicated that H. spectabilis renders H. pictus as paraphyletic, and therefore revisions are needed to resolve this paraphyly. Phylogenetic trees based on mitochondrial DNA and nuclear DNA genes were constructed using maximum likelihood and Bayesian methods, grouping individuals into previously established Cytochrome b (Cytb) haplogroups across the geography. Phylogenetic trees were run through bPTP and GMYC analyses to estimate the number of predicted species that may be present, and when these lineages likely diverged based on the genes tested. To assist with species delimitation predictions (based on the Genetic Species Concept), intra- and interspecific Kimura two-parameter (K2P) values were calculated to predict species-level lineages within the species complex. We found evidence to support the hypothesis that there are multiple cryptic species present within H. pictus, with some K2P values between the Cytb haplogroups being on par with what is expected between different species and genera within Rodentia. This is further supported by the phylogenetic trees (individual and concatenated) constructed from Cytb and three nuclear genes (Bfib, IRBP, and PRKCI), which consistently group certain Cytb haplogroups together in ways that correspond to geographic filter barriers in Mexico.
Coculturing rice with aquatic animals promotes ecological intensification of paddy ecosystem
Authors: Ji Zi-Jun , Zhao Lu-Feng , Zhang Tao-Jie , Dai Ran-Xin , Tang Jian-Jun , Hu Liang-Liang , Chen Xin 
Published: May 2023

AbstractSpecies coculture can increase agro-biodiversity and therefore constitutes an ecological intensification measure for agriculture. Rice–aquatic animal coculture, one type of species coculture, has been practiced and researched widely. Here, we review recent studies and present results of a quantitative analysis of literature on rice–aquatic animal coculture systems. We address three questions: (i) can rice yield and soil fertility be maintained or increased with less chemical input through rice–aquatic animal coculture? (ii) how do aquatic animals benefit the paddy ecosystem? (iii) how can coculture be implemented for ecological intensification? Meta-analysis based on published papers showed that rice–aquatic animal cocultures increased rice yield, soil organic carbon and total nitrogen and decreased insect pests and weeds compared with rice monocultures. Studies also showed that rice–aquatic animal cocultures reduced pesticide and fertilizer application compared with rice monocultures. Rice plants provide a beneficial environment for aquatic animals, leading to high animal activities in the field. Aquatic animals, in turn, help remove rice pests and act as ecological engineers that affect soil conditions, which favor the growth of rice plants. Aquatic animals promote nutrient cycling and the complementary use of nutrients between rice and aquatic animals, which enhances nutrient-use efficiency in the coculture. To generate beneficial outcomes, how to develop compatible partnerships between rice and aquatic animals, and compatible culturing strategies for coculture systems are the key points. Investigating which traits of aquatic animals and rice varieties could best match to create productive and sustainable coculture systems could be one of the future focuses.
Dioscorides and Galen in the Syriac Tradition: A Reconsideration of Three Passages About Herbs in an Anonymous Syriac Pharmacological Book
Authors: Lin Lijuan 
Published: May 2023

Abstract
This article centres on three passages about herbs and herb remedies (§91, §92 and §97) selected from the anonymous Syriac pharmacological book which Philippe Gignoux recently edited. It argues that all three passages have parallels in Galen’s On Simple Drugs, while the last section of §91 finds a parallel in Dioscorides’ De materia medica 1.107. The parallels not only help us to decipher several terms which remain unresolved in earlier research, but also facilitate a better understanding of some passages which are occasionally misleading due to the highly abbreviated character of the Syriac text. Furthermore, a comparison between the anonymous Syriac pharmacological text and earlier Syriac translations of Galen shows that our text is a multiple-layered pharmacopoeia which combines both earlier elements from Sergius of Rēš ͑ainā in the sixth century and new terminologies from Ḥunayn ibn Isḥāq in the ʿAbbāsid translation movement.
Multidisciplinary approach to the treatment of sexual dysfunction in couples using a biopsychosocial model
Authors: Lynn Mary , Iftekhar Noama , Adams William , Mumby Patricia 
Published: May 2023

Abstract

Background
Given the complexity of the psychological and biological pathologies associated with sexual dysfunction, which affects at least a third of adult women and men worldwide, a multidisciplinary approach has been advocated.

Aim
To assess sexual functioning, relationship satisfaction, and mood stability pre- and post- treatment at the Loyola University Sexual Wellness Program.

Methods
Couples attending the 6-week multidisciplinary Sexual Wellness Program provided consent and completed pre- and post- intervention assessments. Linear mixed effects models were used to estimate the mean change from baseline to first follow-up. A covariance matrix was used to account for dependency.

Outcomes
All patients completed self-reported surveys: Dyadic Adjustment Scale, PROMIS Sexual Function and Satisfaction Measures Brief Profile (Patient-Reported Outcomes Measurement Information), and International Index of Erectile Function.

Results
There were 85 respondents: 42 men and 43 women. The mean age was 49.82 years (range, 25-77). The largest improvement was on the total Dyadic Adjustment Scale score, which increased by approximately 5.18 points (95% CI, 2.55-7.81). PROMIS scores for global satisfaction with sex life, erectile function, and interest in sexual activity significantly increased from baseline, while the vaginal discomfort score significantly declined. Overall the score for global satisfaction with sex life increased from baseline by approximately 5.57 points (95% CI, 3.03-8.10). On average, men reported a 4.33-point increase (95% CI, 0.04-8.62) in their International Index of Erectile Function score from baseline.

Clinical Implications
A multidisciplinary treatment approach focused on the couple positively affects a couple’s relationship, including global satisfaction with sex life, relationship satisfaction, interest in sexual activity, and erectile function.

Strengths and Limitations
This study is one of the few to document the effects of a multidisciplinary treatment approach for both members of a heterosexual couple—male and female. Limitations include the narrow demographics and lack of a control group in our population. Furthermore, this was completed at 1 academic center.

Conclusion
These findings emphasize that multidisciplinary sexual therapy programs aimed at the couple can help address multiple aspects of sexual well-being.
Plant biochemical genetics in the multiomics era
Authors: Alseekh Saleh , Karakas Esra , Zhu Feng , Wijesingha Ahchige Micha , Fernie Alisdair R 
Published: May 2023

AbstractOur understanding of plant biology has been revolutionized by modern genetics and biochemistry. However, biochemical genetics can be traced back to the foundation of Mendelian genetics; indeed, one of Mendel’s milestone discoveries of seven characteristics of pea plants later came to be ascribed to a mutation in a starch branching enzyme. Here, we review both current and historical strategies for the elucidation of plant metabolic pathways and the genes that encode their component enzymes and regulators. We use this historical review to discuss a range of classical genetic phenomena including epistasis, canalization, and heterosis as viewed through the lens of contemporary high-throughput data obtained via the array of approaches currently adopted in multiomics studies.
Deciphering transcriptional mechanisms of maize internodal elongation by regulatory network analysis
Authors: Ren Zhaobin , Liu Yingru , Li Lu , Wang Xing , Zhou Yuyi , Zhang Mingcai , Li Zhaohu , Yi Fei , Duan Liusheng 
Published: May 2023

Abstract
The lengths of the basal internodes is an important factor for lodging resistance of maize (Zea mays). In this study, foliar application of coronatine (COR) to 10 cultivars at the V8 growth stage had different suppression effects on the length of the eighth internode, with three being categorized as strong-inhibition cultivars (SC), five as moderate (MC), and two as weak (WC). RNA-sequencing of the eighth internode of the cultivars revealed a total of 7895 internode elongation-regulating genes, including 777 transcription factors (TFs). Genes related to the hormones cytokinin, gibberellin, auxin, and ethylene in the SC group were significantly down-regulated compared to WC, and more cell-cycle regulatory factors and cell wall-related genes showed significant changes, which severely inhibited internode elongation. In addition, we used EMSAs to explore the direct regulatory relationship between two important TFs, ZmABI7 and ZmMYB117, which regulate the cell cycle and cell wall modification by directly binding to the promoters of their target genes ZmCYC1, ZmCYC3, ZmCYC7, and ZmCPP1. The transcriptome reported in this study will provide a useful resource for studying maize internode development, with potential use for targeted genetic control of internode length to improve the lodging resistance of maize.
Boundless baryons: how diffuse gas contributes to anisotropic tSZ signal around simulated Three Hundred clusters
Authors: Lokken Martine , Cui Weiguang , Bond J Richard , Hložek Renée , Murray Norman , Davé Romeel , van Engelen Alexander 
Published: May 2023

ABSTRACT
Upcoming advances in galaxy surveys and cosmic microwave background data will enable measurements of the anisotropic distribution of diffuse gas in filaments and superclusters at redshift z = 1 and beyond, observed through the thermal Sunyaev–Zel’dovich (tSZ) effect. These measurements will help distinguish between different astrophysical feedback models, account for baryons that appear to be ‘missing’ from the cosmic census, and present opportunities for using locally anisotropic tSZ statistics as cosmological probes. This study seeks to guide such future measurements by analysing whether diffuse intergalactic gas is a major contributor to anisotropic tSZ signal in The Three Hundred  Gizmo-Simba  hydrodynamic simulations. We apply multiple different halo boundary and temperature criteria to divide concentrated from diffuse gas at z = 1, then create mock Compton- y maps for the separated components. The maps from 98 simulation snapshots are centred on massive galaxy clusters, oriented by the most prominent filament axis in the galaxy distribution, and stacked. Results vary significantly depending on the definition used for diffuse gas, indicating that assumptions should be clearly defined when claiming observations of the warm-hot intergalactic medium. In all cases, the diffuse gas is important, contributing 25–60 per cent of the tSZ signal in the far field (&gt;4 h−1 comoving Mpc) from the stacked clusters. The gas 1–2 virial radii from halo centres is especially key. Oriented stacking and environmental selections help to amplify the signal from the warm-hot intergalactic medium, which is aligned but less concentrated along the filament axis than the hot halo gas.
SDSS-IV MaNGA: The incidence of major mergers in type I and II AGN host galaxies in the DR15 sample
Authors: Hernández-Toledo H M , Cortes-Suárez E , Vázquez-Mata J A , Nevin R , Ávila-Reese V , Ibarra-Medel H , Negrete C A 
Published: May 2023

ABSTRACT
We present a study on the incidence of major mergers and their impact on the triggering of nuclear activity in 47 type I and 236 type II optically selected AGN from the MaNGA DR15 sample. From an estimate of non-parametric image predictors (Gini, M20, concentration (C), asymmetry (A), clumpiness (S), Sérsic index (n), and shape asymmetry (AS)) using the SDSS images, in combination with a Linear Discriminant Analysis Method, we identified major mergers and merger stages. We reinforced our results by looking for bright tidal features in our post-processed SDSS and DESI legacy images. We find a statistically significant higher incidence of major mergers of 29 per cent ± 3 per cent in our type I+II AGN sample compared to 22 per cent ± 0.8 per cent for a non-AGN sample matched in redshift, stellar mass, colour, and morphological type, finding also a prevalence of post-coalescence (51 per cent ± 5 per cent) over pre-coalescence (23 per cent ± 6 per cent) merger stages. The levels of AGN activity among our massive major mergers are similar to those reported in other works using [O iii] tracers. However, similar levels are produced by our AGN-galaxies hosting stellar bars, suggesting that major mergers are important promoters of nuclear activity but are not the main nor the only mechanism behind the AGN triggering. The tidal strength parameter Q was considered at various scales looking for environmental differences that could affect our results on the merger incidence, finding non-significant differences. Finally, the H-H β diagram could be used as an empirical predictor for the flux coming from an AGN source, useful to correct photometric quantities in large AGN samples emerging from surveys.
Androgen signalling in the ovaries and endometrium
Authors: Lissaman Abbey C , Girling Jane E , Cree Lynsey M , Campbell Rebecca E , Ponnampalam Anna P 
Published: May 2023

Abstract
Currently, our understanding of hormonal regulation within the female reproductive system is largely based on our knowledge of estrogen and progesterone signalling. However, while the important functions of androgens in male physiology are well known, it is also recognized that androgens play critical roles in the female reproductive system. Further, androgen signalling is altered in a variety of gynaecological conditions, including endometriosis and polycystic ovary syndrome, indicative of regulatory roles in endometrial and ovarian function. Co-regulatory mechanisms exist between different androgens, estrogens, and progesterone, resulting in a complex network of steroid hormone interactions. Evidence from animal knockout studies, in vitro experiments, and human data indicate that androgen receptor expression is cell-specific and menstrual cycle stage-dependent, with important regulatory roles in the menstrual cycle, endometrial biology, and follicular development in the ovaries. This review will discuss the expression and co-regulatory interactions of androgen receptors, highlighting the complexity of the androgen signalling pathway in the endometrium and ovaries, and the synthesis of androgens from additional alternative pathways previously disregarded as male-specific. Moreover, it will illustrate the challenges faced when studying androgens in female biology, and the need for a more in-depth, integrative view of androgen metabolism and signalling in the female reproductive system.