bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of regional water cycle health based on EFAST-cloud model: A case study of Henan Province, China
Authors: Liu Peiheng , Han Yuping , Lü Subing , Wang Fuqiang 
Published: February 2023

Abstract
The regional water cycle is increasingly reflecting the dual role of natural and social processes, and is affected by global climate change and strong human intervention. The study of water cycle health evaluation has provided guidance to urban planning, development, and resource management. In this study, a water cycle health evaluation method based on EFAST-Cloud model is proposed, and Henan Province of China is selected as a typical study area. The water cycle health status is evaluated from four dimensions of water ecology, water quality, water abundance, and water utilization. The evaluation results are compared with those of fuzzy comprehensive evaluation as well. It is shown that the established EFAST-Cloud model results of assessment are consistent with the Fuzzy comprehensive evaluation method, while it has the advantage of being able to evaluate the proportion of each grade in detail by reflecting the randomness and fuzziness of the evaluation. According to the statistical data from 2007 to 2018, the whole area is in a sub-healthy state. During the 12-year period, the health status of the water cycle has been improved year by year. The research results can provide theoretical basis for repairing regional water environment and promoting regional sustainability.
Slow filtration operating conditions for the removal of opportunistic pathogens in a secondary effluent
Authors: Sun Lihua , Zhang Muxi , Zhu Junyao , Xi Zixuan , Feng Cuimin 
Published: February 2023

ABSTRACT

The secondary effluent of urban sewage treatment plants contains many opportunistic pathogens (OPs), which pose a potential threat to human health. In this study, the slow filtration technique is employed as the advanced treatment procedure, with the secondary effluent as the treatment object. The effectiveness of the operating conditions of the slow filtration process (filtration rate and Ca2+ concentration) in removing OPs (Pseudomonas aeruginosa, Legionella and Mycobacterium avium) and Escherichia coli from water, as well as the dynamic deposition process of pollutants on the surface of the slow filtration biofilm, was investigated. The results showed that under different filtration rates and different Ca2+ concentrations, biofilm slow filtration was more effective in removing OPs than slow filtration. The optimal filtration rate of biofilm slow filtration was 5 cm/h, and the optimal inlet Ca2+ concentration was 60 mg/L. When the filtration rate was 5 cm/h, the deposition of pollutants in the secondary effluent on the surface of biofilm slow filtration was mainly dominated by the physical adhesion of extracellular polymeric substances (EPS). When the concentration of Ca2+ was 60 mg/L, the adsorption of microorganisms was the primary method.
Strategies for Treatment of Thyroid Cancer
Authors: Yadav Deepika , Mishra Prem Shankar , Sharma Pramod Kumar , Malviya Rishabha 
Published: February 2023

Abstract:
More people are diagnosed with thyroid cancer than any other endocrine tumor. Differentiated
thyroid cancer is often treated by removing the thyroid gland (thyroidectomy), iodizing radiation,
or inhibiting thyroid stimulating hormone (TSH). Advanced thyroid carcinomas are notoriously
resistant to chemotherapy, thus the pursuit of alternative treatments is vital. The best methods
for treating individuals with advanced nonmedullary and medullary thyroid carcinomas are discussed
in this post. Numerous tyrosine kinase inhibitors and antiangiogenic inhibitors, two types of
novel target therapy, have shown promise in studies for individuals with thyroid cancer. Both the
positive and unfavourable outcomes of clinical studies of these drugs were addressed. The findings
presented here are encouraging, but more study is required to establish whether or not this method
is effective in the treatment of thyroid cancer.
Andrographis paniculata and Andrographolide - A Snapshot on Recent
Advances in Nano Drug Delivery Systems against Cancer
Authors: Deshmukh Rohitas , Jain Aman Kumar , Singh Rajesh , Paul Swarnali Das , Harwansh Ranjit K. 
Published: February 2023

Abstract:
Cancer is one of the deadliest illnesses of the 21st century. Chemotherapy and radiation therapies
both have considerable side effects. Antitumor antibiotics are one of them. Coughs, common colds,
fevers, laryngitis, and infectious disorders have all been treated with Andrographis paniculata for centuries.
Extracts of Andrographis effectively treat various ailments, as well as cancer. The most active
molecule in Andrographis paniculata is andrographolide a, diterpene, and lactone. Andrographis paniculata
and its derivatives have long been used to treat various ailments. Anti-inflammatory and cancerfighting
characteristics have been observed in Andrographolide. Andrographolide, a diterpene lactone
separated from Andrographis paniculata, has also been shown to have important criticalessential biological
protective properties. It has also been suggested that it could be used to treat major human diseases
like-rheumatoid like rheumatoid, colitis, and Parkinsons disease. This summary aims to highlight
Andrographolide as a promising cancer treatment option. Several databases were searched for andrographolides
cytotoxic/anti-cancer effects in pre-clinical and clinical research to serve this purpose. Several
studies have shown that Andrographolide is helpful in cancer medication, as detailed in this review.
Acridine: A Scaffold for the Development of Drugs for Alzheimer's Disease
Authors: Sharma Anuradha , Piplani Poonam 
Published: February 2023

Abstract:
Alzheimer's disease (AD) is drawing scientists' consideration, being one of the gravest diseases mankind will have to battle against in the near future. The number of people with AD is expected to triple in the next 40 years. It is a most common age-related multifactorial neurodegen-erative disease and characterized by two histopathological hallmarks; the formation of senile plaques composed of the amyloid-β (Aβ) peptide and neurofibrillary tangles composed of hyper-phosphorylated tau protein. Discovery and development of rationally designed multi-targeted lig-ands for the management of AD could be more beneficial than classical single targeted molecules. Acridine, a heterocyclic nucleus is a sole moiety in various existing drug molecules such as quina-crine (antimalarial), acriflavine and proflavine (antiseptics), ethacridine (abortifacient), amsacrine and nitracine (anticancer) and tacrine (anti-Alzheimer). It is proposed that acridine may combat the AD by acting on several targets like acetylcholinesterase (AChE), butyrylcholinesterase (BuChE), dual specificity tyrosine kinase 1A (Dyrk 1A), amyloid and prion protein (PrPC) etc. involved in its pathogenesis. The main aim of this compilation is to review the most promising therapeutic devel-opments within the vast research area dealing with acridine derivatives. Further research is required to evaluate the effectiveness of the acridine derivatives with various substitutions in the treatment of AD. In conclusion, our review will suggest the potentiality of the versatile acridine framework for drug designing and developing novel multi-target inhibitors for the Alzheimer’s disease.
Investigating Biomarkers for COVID-19 Morbidity and Mortality
Authors: Fiore Marco , Ceci Flavio Maria , Ferraguti Giampiero , Lucarelli Marco , Angeloni Antonio , Bonci Enea , Petrella Carla , Francati Silvia , Barbato Christian , Di Certo Maria Grazia , Gabanella Francesca , Gavaruzzi Francesca , Mastroianni Claudio Maria , Minni Antonio , Greco Antonio , Ralli Massimo , Ceccanti Mauro , Tarani Luigi 
Published: February 2023

Background and Objective:
This retrospective study aims to disclose further early pa-rameters of COVID-19 morbidity and mortality.

Methods:
Three hundred and eighty-two COVID-19 patients, recruited between March and April 2020, were divided into three groups according to their outcome: (1) hospital ward group (patients who entered the hospital wards and survived); (2) intensive care unit (ICU) group (patients who at-tended the ICU and survived); (3) the deceased group (patients admitted to ICU with a fatal out-come). We investigated routine laboratory parameters such as albumin, glycemia, hemoglobin am-ylase, lipase, AST, ALT, GGT, LDH, CK, MGB, TnT-hs, IL-6, ferritin, CRP, PCT, WBC, RBC, PLT, PT, INR, APTT, FBG, and D-dimer. Blood withdrawal was carried out at the beginning of the hospitalization period.

Results:
ANOVA and ROC data evidenced that the concomitant presence of alterations in albumin, lipase, AST, ALT, LDH, MGB, CK, IL-6, ferritin in women, CRP and D-dimer is an early sign of fatal outcomes.

Conclusion:
The present study confirms and extends the validity of routine laboratory biomarkers (i.e., lipase, AST, ALT, LDH, CK, IL-6, ferritin in women, CRP and D-dimer) as indicators of COVID-19 morbidity and mortality. Furthermore, the investigation suggests that both gross changes in albumin and MGB, markers of liver and heart damage, may early disclose COVID-19 fatal out-comes.
New Perspectives of Taxifolin in Neurodegenerative Diseases
Authors: Yang Rong , Yang Xinxing , Zhang Feng 
Published: February 2023

Abstract:
Neurodegenerative diseases, such as Alzheimer’s disease (AD), Parkinson’s disease (PD),
cerebral amyloid angiopathy (CAA), and Huntington’s disease (HD) are characterized by cognitive
and motor dysfunctions and neurodegeneration. These diseases have become more severe over time
and cannot be cured currently. Until now, most treatments for these diseases are only used to relieve
the symptoms. Taxifolin (TAX), 3,5,7,3,4-pentahydroxy flavanone, also named dihydroquercetin, is a
compound derived primarily from Douglas fir and Larix gemelini. TAX has been confirmed to exhibit
various pharmacological activities, including anti-inflammation, anti-cancer, anti-virus, and regulation
of oxidative stress effects. In the central nervous system, TAX has been demonstrated to inhibit Aβ fibril
formation, protect neurons and improve cerebral blood flow, cognitive ability, and dyskinesia. At
present, TAX is only applied as a health additive in clinical practice. This review aimed to summarize
the application of TAX in neurodegenerative diseases and the underlying neuroprotective mechanisms,
such as suppressing inflammation, attenuating oxidative stress, preventing Aβ protein formation,
maintaining dopamine levels, and thus reducing neuronal loss.
Alcoholic/Nonalcoholic Fatty Liver Disease Detection with Transient
Elastography: A Detailed Review and Meta-analysis
Authors: Fang Yinyou , Li Xiaofei , Zong Fang , Jiang Tianan 
Published: February 2023

Background:
The liver plays a significant role in the digestive system, and disease in the liver initiates various other problems. The liver is severely affected due
to alcohol use, and it initiates various chronic diseases, including Alcohol-Related Liver Disease (ARLD). Alcoholic/Nonalcoholic Fatty Liver
Disease (AFLD/NFLD) is a severe medical emergency, and early screening and treatment are necessary to cure the patient. The untreated
AFLD/NFLD will cause various problems, including fatigue, weight loss, and discomfort in the abdomen.

Objective:
This study aims to present a detailed review and investigation of schemes considered in medical clinics to identify the AFLD/NFLD coupled
problems and present the merit of the Transient Elastography (TE) combined with Fibroscan® practice to identify liver abnormality.

Methods:
This research aims to study the clinical significance and the accuracy of TE-supported liver illness screening.

Results:
This work aims to collect the recent research works and clinical reports published from 2011 to 2021 from the chosen databases and provide a
detailed review using the clinical information discussed in the selected articles.

Conclusion:
The essential statistical investigation of the collected data is executed with Review Manager (RevMan®) software, and the significance of the TE is
confirmed using the articles supporting a 2x2 contingency table, and each case is evaluated using a p-score and the Region of Convergence (RoC)
curve for 95% confidence intervals.
Exploring the Mechanism of Buyang Huanwu Decoction Alleviating Restenosis by Regulating VSMC Phenotype Switching and Proliferation by Network Pharmacology and Molecular Docking
Authors: Chen Xueqin , Yu Jingyue , Lei Huan , Li Lei , Liu Xupin , Liu Bo , Xie Yanfei , Fang Haihong 
Published: February 2023

Background:Buyang Huanwu Decoction (BHD) is used to regulate blood circulation and clear collaterals and is widely used in coronary heart disease. However, the active compounds and the mechanism of BHD used to treat restenosis are less understood.Objective:The study aimed to explore the potential mechanism of Buyang Huanwu decoction BHD for the treatment of restenosis using network pharmacology and molecular docking experiments.Methods:The bioactive components of BHD and their corresponding targets were retrieved from the Traditional Chinese Medicine Systems Pharmacology (TCMSP) and Encyclopaedia of Traditional Chinese Medicine (ETCM) databases as well as literature. Restenosisassociated therapeutic genes were identified from the OMIM, Drugbank, GEO, and Dis- GeNET databases. Genes related to the vascular smooth muscle cell (VSMC) phenotype were obtained from the gene ontology (GO) database and literature. The core target genes for the drug-disease-VSMC phenotype were identified using the Venn tool and Cytoscape software. Moreover, the “drug-component-target-pathway” network was constructed and analyzed, and pathway enrichment analysis was performed. The connection between the main active components and core targets was analyzed using the AutoDock tool, and PyMOL was used to visualize the results.Result:The “compound-target-disease” network included 80 active ingredients and 599 overlapping targets. Among the bioactive components, quercetin, ligustrazine, ligustilide, hydroxysafflor yellow A, and dihydrocapsaicin had high degree values, and the core targets included TP53, MYC, APP, UBC, JUN, EP300, TGFB1, UBB, SP1, MAPK1, SMAD2, CTNNB1, FOXO3, PIN1, EGR1, TCF4, FOS, SMAD3, and CREBBP. A total of 365 items were obtained from the GO functional enrichment analysis (p < 0.05), whereas the enrichment analysis of the KEGG pathway identified 30 signaling pathways (p < 0.05), which involved the TGF-β signaling pathway, Wnt signaling pathway, TRAF6-mediated induction of NF-κB and MAPK pathway, TLR7/8 cascade, and others. The molecular docking results revealed quercetin, luteolin, and ligustilide to have good affinity with the core targets MYC and TP53.Conclusion:The active ingredients in BHD might act on TP53, MYC, APP, UBC, JUN, and other targets through its active components (such as quercetin, ligustrazine, ligustilide, hydroxysafflor yellow A, and dihydrocapsaicin). This action of BHD may be transmitted via the involvement of multiple signaling pathways, including the TGF-β signaling pathway, Wnt signaling pathway, TRAF6-mediated induction of NF-κB and MAPK pathway, and TLR7/8 cascade, to treat restenosis by inhibiting the phenotype switching and proliferation of VSMC.
Protective Effect of Quercetin against Paraquat-induced Brain Mitochondrial
Disruption in Mice
Authors: Saberi-Hasanabadi Parisa , Sedaghatnejad Reza , Mohammadi Hamidreza 
Published: February 2023

Background:
Paraquat is a highly toxic quaternary ammonium herbicide widely used in
agriculture. It is an agent that induces pulmonary toxicity via the redox cyclic reaction.

Objective:
The present study investigated the protective effect of quercetin against paraquatinduced
brain mitochondria disruption in mice.

Methods:
Paraquat (1.25 mg/kg, intraperitoneally) was administered to the mice, and then quercetin
(50, 100, 200 mg/kg) was injected i.p. Oxidative damage biomarkers such as reactive oxygen
species, protein carbonyl, lipid peroxidation, glutathione content, and mitochondrial function were
assessed in the brain mitochondria.

Results:
The results showed that paraquat significantly (P < 0.001) increased the reactive oxygen
species, protein carbonyl, and lipid peroxidation and significantly (P < 0.0001) decreased the glutathione
content and mitochondrial function in the brain cells. Administration of the quercetin at
doses of 50, 100, and 200 mg/kg significantly reduced reactive oxygen species, lipid peroxidation,
and protein carbonyl and improved mitochondrial function and glutathione content in the mice
brain mitochondrial compared to the paraquat group. Quercetin at 200 mg/kg dose had better effectiveness
than 50 and 100 mg/kg doses.

Conclusion:
Our results suggest that quercetin in a dose-dependent manner has neuroprotective effects,
probably by free radicals scavenging or enhancing the antioxidant mechanisms in the brain
mitochondria. It seems that quercetin could modulate protein and lipid oxidation and improve oxidative
damage induced by paraquat in the early stages.
Antibacterial and Antioxidant Superoxide Anion Radical Inhibitors from
Myrmecodia pendans: An In silico Study
Authors: Ramadhanty Zenika Febian , Kurnia Dikdik , Situmeang Boima , Hemiawati Mieke , Asmah Nur 
Published: February 2023

Background:
Background: Ant-nest (Myrmecodia pendans) is an epiphytic plant that can prevent several
diseases, including bacterial infections. Diarrhea is caused by Escherichia coli bacteria, while infections
in the oral cavity can be caused by Enterococcus faecalis bacteria. Antibacterial activity is also influenced
by conditions of Reactive Oxygen Species (ROS). Antioxidants are needed to inhibit the formation of
excess ROS in the body. Superoxide anion radicals are included in the generation of ROS, which is produced
by several enzymes, such as nicotinamide-adenine dinucleotide phosphate (NADPH) oxidase or
commonly known as Nox and xanthine oxidase (XO).

Objective:
This study aimed to determine the potential of M. pendans as an antibacterial in vitro and in
silico correlation in the formation of superoxide anion radicals.

Methods:
The compounds were obtained by column chromatography method, followed by a spectroscopic
examination. In vitro test using the disc diffusion method and in silico test using AutoDock 4.2 program
were conducted with positive control fosfomycin and allopurinol, tethered to MurA, Nox, and XO
enzymes, and visualized using the Discovery Studio 2020.

Results:
Compound 1 (oleanolic acid) and compound 2 (pomolic acid) demonstrated antibacterial activity
against E. coli but no activity against E. faecalis. Compound 3 (3-hydroxy-eupan-20,24-dien-26-oic acid)
demonstrated no activity against these two bacteria. Based on the in silico results, compound 3 had the
best binding energy affinity for all MurA, Nox, and XO enzymes of -6.89, -9.35, and -9.75 Kcal/mol,
respectively. Similarly, compounds 1 and 2 had good binding energies for Nox protein of -9.29 Kcal/mol
and -6.54 Kcal/mol and XO of -7.66 and -4.7 Kcal/mol, respectively.

Conclusion:
In vitro results against E. coli and E. faecalis bacteria showed inhibition by compounds 1
and 2 but not by compound 3. Meanwhile, in in silico analysis, all the compounds showed potential as an
inhibitor of superoxide anion radicals generated by enzymes Nox and XO.
Microwave Synthesizer: A Biomedical Engineering Technique With
Advanced Applications
Authors: Silakari Pragati , Singh Jyoti , Sharma Shaveta 
Published: February 2023

Abstract:
In current times, all major discoveries are believed to occur at the intersections of various
fields of science. In such a manner, perhaps the main creative region joining material science,
biology and medication is the utilization of microwave advances. In such a way, the motivation
behind this work was to explain the useful conceivable outcomes of diagnostic, analytical, synthetic
and therapeutic microwave advancements. The related exploration and uses of microwave
(MW) science are the arising methodologies of modern energy-based green science, on a nuclear
and atomic self-aggregating level. As microwaves develop the synthetic response, they have the
potential to greatly impact the chemical reaction. This technology has advanced its utilization in
the field of research technology, chemical synthesis, diagnostic chemistry, wastewater treatment,
and material science. This article cumulates the various available microwave synthesizers in the
market with their pros and cons alongside their wide applications.
Formulation and Evaluation of Herbal Hair Dye: A Laboratory Scale
Project
Authors: Syed Shoaeb Mohammad , Holkar Ajinkya , Thore Priyanka , Vaidya Sakshi 
Published: February 2023

Aim:
This research was conducted to make the option for chemical-based semisynthetic
and synthetic hair dyes to overcome the problems with the use of synthetic dyes and the
acceptance rate by the public. The work involves the use of some novel natural ingredients with
novel combinations.

Methods:
The herbal hair dye was prepared y using various natural agents reported to possess
the desired properties. The plants were collected from the herbal garden of Dr. VedprakashPatil
Pharmacy College, Aurangabad & authenticated by the Dept. of Pharmacognosy. All ingredients
were passed through sieves and mixed thoroughly to get a homogenous mixture; the mixture
was dissolved in water and applied to the hairs for the evaluation of various parameters
such as organoleptic physicochemical, patch test & stability.

Results:
This Herbal hair dye prepared in the laboratory is made with all good quality materials.
It was tested in the laboratory and was found to be very safe for the regular use of this herbal
hair dye after several time intervals of time. All evaluation parameters were found to be within
the limits as prescribed for the safe use of hair dye.

Conclusion:
The prepared herbal hair dye neither shows any side effects nor skin infections. It
nourishes the skin on the scalp and hair. This herbal hair dye also aids in dandruff treatment by
removing excess oil from the scalp. If such herbal dye is used frequently or regularly, it will
give a manageable, fizz-free colored hair benefiting human as well as the industry. The formulation
is natural in origin with effective benefits compared to the marketed formulation and
cost-effective.

:
As the process is simple, small scale cosmetic industry can make use of the technique.
contratos públicos de las Empresas Productivas del Estado
Authors: Cancino Gómez Rodolfo 
Published: February 2023

La Contratación Pública en materia energética representa un esquema de apertura comercial y promoción de la inversión extranjera mediante un marco legal especializado para regular un nuevo régimen ad hoc de contratación, que tiene implicaciones directas con los tratados comerciales internacionales tales como el Tratado Integral y Progresista de Asociación Transpacífico (TIPAT) y el Nuevo Tratado de Libre Comercio (TMEC), los cuales interactúan de una forma u otra a través de la operación de los mismos capítulos que los conforman y se interrelacionan entre sí. Esto significa que el sector energético que está reservado para el Estado permite la participación de privados a través de contratos públicos, pero restringir su participación en el mercado mediante modificaciones legales internas puede violentar los compromisos adoptados a nivel internacional.