bluuebunny/crossref_metadata_2025_split huggingface dataset:
EXPERIENCE OF USING THE IMMUNE-COMPLEX VACCINE PULVAK MAGNIPLEX IN THE PREVENTION OF INFECTIOUS BURSA DISEASE OF BROILERS
Authors: Avdosieva I. K. , Basarab O. B. , Chaikovska O. I. , Rudyk Yu. P. 
Published: June 2023

The article presents the results of serological control of the effectiveness of vaccination of broilers against infectious bursal disease (IBD) when the immune-complex vaccine Pulvak MagniPlex is used in the incubator.
Immune-complex vaccines are vaccines of a new generation, the use of which completely eliminates post-vaccination complications in birds and interference phenomena. The vaccine includes a mixture of specific antibodies and the vaccine strain of the IBH virus. The main property of these vaccines is that when administered subcutaneously in day-old chicks or 18-day-old chicken embryos by the in ovo method, immunity is quickly created even in the presence of high maternal antibodies (MAB). Vaccination in the incubator using immune-complex vaccines is more accurate and provides protection to the whole bird, unlike live vaccines, the main method of which is administration with drinking water. Immuno-complex vaccines are effective even in the presence of high MAT in chickens. Due to this, they provide a much higher level of protection due to the high homogeneity of protective antibodies compared to live attenuated vaccines.
We present the data of serological monitoring on the average titer of antibodies to the IBH virus in blood sera from 15 batches of broilers aged 45-50 days, which were immunized on the first day in the incubator with the immune-complex vaccine Pulvak MagniPlex. It was established that during a single vaccination in the incubator (15 batches), the Pulvak MagniPlex vaccine stimulates the formation of an active immune response to the IBH virus for the entire period of fattening of broilers. The average titers in the blood sera of broilers aged 45-50 days to the IBH virus ranged from 6,995 to 12,388 after a single vaccination in the incubator (15 batches). The percentage of protective antibodies to the IBH virus in 15 batches of broilers varied from 77.3 to 100, which indicates the intensity of immunity to IBH. A single application of the immune-complex vaccine Pulvak MagniPlex in the incubator stimulates the formation of an active immune response to the IBD virus for the entire period of broiler fattening and provides 100 % protection of 12 batches of broilers and 77.3 % of broilers of 3 batches to IBD. The use of Pulvak MagniPlex allows: to create stable immunity against IBD; to form immunity in each individual broiler, regardless of the level of maternal antibodies; to reduce the impact of stress (compared to mass vaccination in the poultry house by the drinking method. Constant control of the effectiveness of the Pulvak MagniPlex immune-complex vaccine by means of serological monitoring of blood sera in ELISA will allow, depending on the epizootic situation, to timely adjust the vaccination scheme of poultry against IBD.
POTENTIATION OF PROBIOTIC ACTIVITY BY SIMULTANEOUS USE OF AEROCOCCUS VIRIDANS AND MYCOBACTERIUM VACCAE
Authors: Biben I. A. , Sosnytskyi O. I. , Zazharskyi V. V. , Sosnytska A. O. , Useeva N. G. 
Published: June 2023

In modern animal husbandry, progressive intensive technologies for keeping animals and the productive exploitation of animals are economically efficient, but they deplete the physiological reserves of the body and lead to undesirable pathophysiological changes of a complex nature. The immune-reactive potential of the integral and censoring systems of the macroorganism decreases, the metabolic activity of enzyme complexes at the level of cells and organs changes, antimicrobial resistance decreases, and the quantitative and qualitative composition of the normal flora of the covering tissues and hollow organs is disturbed. The stress of debilitating technological leads to systemic pathologies of infectious and non-infectious origin and deterioration of the health and well-being of the animals.
One of the physiological ways of correcting the systemic pathology based on damage to the native bioprotective mechanisms of the macroorganism is the use of resident prokaryotes of the microbiome artificially cultivated and given per os as a feed dietary supplement. In our research, we isolated probiotic cultures of A. viridans and M. vaccae from healthy broiler chickens, studied their biological properties, established their biosafety for other animals, and determined probiotic potencies when used monovalently and in association. It was shown that the combined use of probiotic prokaryotes significantly improves the stimulation of the immune-reactive potential of the macroorganism and, in association, increases the colonization capabilities of indigenous prokaryotes. Isolated probiotic cultures of the resident microbiota are suitable for the production of probiotics and symbiotics for farm and domestic animals and for prophylactic and therapeutic use both in monoculture and in association. Simultaneous use of probiotic associations is more effective than monocultures.
PECULIARITY OF PRODUCT MARKET RESEARCH FOR VETERINARY MEDICINE. MARKETING ASPECT
Authors: Grymak A. V. 
Published: June 2023

With the transition of veterinary enterprises to market relations, issues of improving the quality, respectively, and competitiveness of products become a priority in their activities, without which it is impossible to defend positions both on domestic and foreign markets.
The experience of the leading enterprises of veterinary medicine confirms that an important condition for competitiveness in the product market is the implementation of marketing research in the practice of their activities, the use of the results of which makes it possible to objectively evaluate one's participation in market relations.
This effectively affects the performance of the enterprise. Implemented and effectively functioning marketing at the enterprise is a kind of system of excellence in planning the strategy of the enterprise, covers all aspects necessary for this, makes them more measurable and aimed at constant improvement in order to achieve a specific goal, the indisputable component of which is quality. And this is an indicator of absolute confidence in one's products, their competitiveness. Therefore, one of the main areas of research of the market of veterinary medicine products is the study and forecasting of its conjuncture, the state of the economy of the industry, the results of the activities of competitors, manufacturers and suppliers of products to the market.
The general purpose of market research is to determine the conditions under which the most complete satisfaction of consumer demand is ensured. Without a doubt, this is one of the directions of market research.
DEVELOPMENT OF METHOD FOR QUANTITATIVE DETERMINATION OF CEFQUINOME SULFATE IN PIGLETS BLOOD PLASMA USING HPLC/DMD
Authors: Melikyan S. , Biront N. , Pazderska O. , Mysko G. , Yanovych D. 
Published: June 2023

This manuscript presents a developed method for determining cefquinome sulfate in piglets blood plasma intended for clinical and pharmaceutical research of veterinary drugs based on it. Blood plasma proteins were precipitated twice with a solution of trichloroacetic acid. The supernatant was further purified by a series of solid-phase extraction. Separation was performed on an inverted phase Kinetex EVO С18 column using acetonitrile and 0,1 % trifluoroacetic acide solusion as the mobile phase. The gradient mode of eluents was used during 10 min at a flow rate of 1,4 ml/min. The peak retention time of cefquinome sulfate is 4,2 min. The specificity of the analytical method was checked by comparing the chromatographic separation of a sample of blood plasma enriched with a standard solution of cefquinome sulfate and a sample of blood plasma placebo. The preparing loaded blood plasma samples procedure for building a calibration graph is described in the article. The validation parameters of the method “recovery” and “coefficient of variation” were considered in accordance with the criteria of Council Directive 2002/657/EC. The procedure of sample preparation of fortified blood plasma to construct calibration graph is described in the manuscript. The mean recovery from fortified blood plasma samples in the range of 0.1-2.0 μg/ml cefquinom sulfate was 102.3 %. The method is linear in the concentration range of 0.1 – 4.0 μg/ml of cefquinome sulfate. The correlation coefficient for the determination method is 0.9998. The results obtained in the study of the linearity of this technique were used to estimate the correctness and convergence. The accuracy of the measurements was evaluated by examining the known amounts of analyte added to the control blood plasma. Recovery data are acceptable because they are within ± 10% of the target value. The method has sufficient convergence (accuracy). The evaluation of the intermediate precision of cefquinome sulfate determination was assessed on three different days of analysis. The limit of detection for cefquinom sulfate is 0.05 μg/ml and limit of quantification - 0.10 μg/ml. The average CV for each compound was <10%. The procedure was confirmed and then applied to determination cefquinome sulfate in the pig blood plasma obtained during the study of the pharmacokinetics of the veterinary drug. The HPLC/DMD method can be used for study of the pharmacokinetics of the veterinary drug.
THE EFFICIENCY OF THE DRUG APPLIKUS-VET IN THE COMPLEX THERAPY OF CATS WITH CLINICAL SIGNS OF ASEPTIC SKIN NECROSIS
Authors: Ostapiuk A. , Pyatnychko O. , Shkodyak N. , Zhyla M. , Lisova N. , Aisina A. 
Published: June 2023

In order to reduce the use of antibiotics for the treatment of skin diseases in dogs and cats it is relevant to introduce alternative drugs that have antimicrobial properties into veterinary practice. Applikus-vet is a new domestic combined veterinary agent for external use, which has adsorption and bactericidal action. The preparation is designed on the basis of hydrogel of methylcremic acid with immobilized Cuprum ions and is intended for the treatment of wounds and ulcerative lesions of the skin. Hydrogel of methylcremic acid has an adsorption capacity, Cuprum ions have an antimicrobial effect and cause the denaturation of microorganism’s proteins.
The article outlines the clinical study of a new veterinary drug Applikus-vet, paste for external use, production of PJSC "EOF" Creom-Farm "(Ukraine), in the treatment of cats with clinical signs of aseptic skin necrosis (brittle skin syndrome).
The drug was used in the complex treatment of two cats of long-haired breeds – female, aged 7 years, and male, 14 years of age, with clinical signs of aseptic skin necrosis in the area of the thoracic, the lumbar departments of the back and abdominal wall. The female had a much larger area of the affected skin than the male. Diagnosis was put on the basis of anamnesis, a clinical picture of the disease. The veterinarian of the clinic prescribed complex therapy, which included the drug Applikus-vet for application to the wounds of animals. The general course of treatment with the test drug lasted 4–8 weeks.
The drug Applikus-vet showed good therapeutic efficiency in the complex treatment of cats with clinical signs of aseptic skin necrosis. Depending on the complexity of the disease, epithelialization and reduction of the inflammatory process in the affected area of animal’s skin were observed on 21–35 days of treatment. A significant decrease in the area of the affected skin and the formation of scars and scab was noted on 28–50 days of treatment. In this case, the drug was well tolerated by animals, didn’t show unexpected negative local and general effects.
According to the results of laboratory tests, the positive effect of the drug Applikus-vet was found in the complex therapy of aseptic skin necrosis on the morpho-functional condition of the cat’s organism, which is confirmed by the normalization of most morphological and biochemical indicators of blood to the values of clinically healthy animals.
Saberes para la sobrevivencia.
Authors: Mejía-Reyes Enrique , Jiménez-Vidiella Lourdes Georgina 
Published: June 2023

Esta propuesta surge a partir de las condiciones del tiempo histórico presente referentes a lo educativo, las cuales exigen hacer un alto para reflexionar sobre los saberes y experiencias para la sobrevivencia que ponen en marcha los sujetos ante un mundo hegemónico que se enfrenta al acontecimiento inédito del COVID-19. Más que pensar la hegemonía como una abstracción la observamos en un capitalismo (nuestro y de los otros) que no es uniforme, demostrado en un patriarcado y en un racismo devastadores y aniquilantes de las subjetividades de los sujetos; frente a eso, aquí buscamos aquellos saberes surgidos en lo limítrofe de la institucionalidad, en ocasiones en concordancia con lo instituido, pero otras muchas en el contrapunteo entre quienes son sujetos de poder y sujetos de diferencia en lo educativo. De este modo, nos interesa visibilizar perspectivas y experiencias de lo educativo estrechamente ligadas con la idea de hacer posible el futuro, para lo cual se precisa reivindicar la centralidad de la vida como vía para la subversión de los valores capitalistas hegemónicos vigentes, tanto a nivel
de experiencias de los sujetos como de ideas de pensadoras y pensadores quienes han enfatizado la noción de sobrevivencia.
A partir de lo dicho, el planteamiento de este artículo es ¿Qué saberes para la sobrevivencia han construido los sujetos para lo educativo?, con lo anterior perseguimos como objetivo: Recuperar los saberes para la sobrevivencia para un futuro de vida dentro del acontecimiento del COVID-19. Sobre este eje se pueden reconstruir las pautas político-culturales para un futuro posible a partir del COVID-19 como acontecimiento inédito y que atrae varios efectos como las amenazas a la vida, el confinamiento, el cambio en la espacialidad de los procesos educativos y la transformación emergente del trabajo docente en la predominancia de la virtualidad.
Propuesta de mejora en el índice de titulación en la licenciatura de médico cirujano de la Facultad de Medicina, UAEMéx
Authors: Miranda-Saucedo Catalina , Arceo-Guzmán Mario , Pimentel-Ramírez María Luisa 
Published: June 2023

Introducción
Se realizó una investigación educativa con el objetivo de evaluar las posibles causas que retrasan la titulación de los estudiantes de la licenciatura de Médico Cirujano, tomando como base los parámetros que valoran la calidad a través de programas educativos de medicina, en donde la Asociación Nacional de Universidades e Instituciones de Educación Superior (ANUIES), contribuye en aportaciones y directrices en la formulación de planes y programas en educación superior, para el mejoramiento de la calidad. Un parámetro a evaluar que refleja productividad de Instituciones de Educación Superior (IES) son egresados y titulados, en donde el índice de titulación es un indicador que estima su funcionamiento y logros. La aportación de una mejora en el proceso a través de la simplificación administrativa beneficiará directamente al alumno y al índice de titulación.
Materiales y Métodos
La metodología utilizada consistió en una revisión histórica de los índices de titulación llevados a cabo durante 2 años en la licenciatura de Médico Cirujano y una breve encuesta realizada a alumnos al azar sobre conocimiento de procedimiento y modalidades de titulación.
Resultados
Los resultados más sobresalientes hacen referencia a la disminución de la titulación aún con las diferentes modalidades de la obtención del documento correspondiente.
Conclusiones
La disminución de la titulación a pesar de las modalidades implementadas se debe a la falta de información que tienen los alumnos sobre la diversidad de opciones para tal fin.
De La Brecha Digital A La Brecha Epistémica: Un Análisis Del Impacto De La COVID 19 En México Agustina Ortiz-Soriano
Authors: Ortiz-Soriano Agustina , Villa-Fajardo Moisés Ramón , Lira-Mendoza Francisco Javier 
Published: June 2023

En el primer trimestre del año 2020, la noticia de la propagación de un virus se escuchaba en todo el mundo, la incertidumbre de lo que podría pasar se apoderó de la mayoría de las personas que habitamos este planeta. Para el segundo trimestre del 2020, tras la llegada de la pandemia mundial originada por el SARS-CoV-2, las esferas de la vida del ser humano se trastocaron, principalmente aquellas que tienen que ver con el contacto y convivencia directo, destacando la esfera educativa.
A partir de un análisis metodológico de corte documental, y de una investigación correlacional del sistema educativo mexicano de educación Preescolar, Primaria y Secundaria. Las variables son: acciones emprendidas como respuesta a la pandemia, condiciones alfabéticas del tutor o padre de familia para hacer el acompañamiento académico, así como el uso y manejo de las tecnologías de la información y comunicación aplicados al conocimiento.
Como resultado de este estudio, detectamos un problema principal, a saber; la brecha digital que tenemos en nuestro país, pues apenas el 44.2% de los hogares cuenta con computadora y el 60.6% con internet, a esto debemos añadir que México no tiene cubierto al 100% el servicio de energía eléctrica, principalmente en zonas rurales.
La conclusión a la que llegamos es, que precisamente esta brecha digital, es la que agudizará la brecha epistémica, la cual, desde la postura de Bonilla (2021), tiene expresiones diferenciadas conforme al desarrollo desigual y combinado del capitalismo, en tanto tiene dimensiones territoriales; no es lo mismo la brecha epistémica en el centro del sistema mundo capitalista que en sus periferias. Sin recursos tecnológicos, fue imposible la permanencia en el sistema educativo, lo que trajo consigo que los porcentajes de abandono y deserción escolar se incrementaran, aún con la política de la Secretaría de Educación Pública de cero reprobados.
PENGARUH PEMBERIAN MINUMAN “KAKATUL” TERHADAP KADARGLUKOSA DARAH PENDERITA DIABETES MELITUS
Authors: Nova Marisa  , Podojoyo Podojoyo , Hana Yuniarti  , Susyani  
Published: June 2023

Latar Belakang: Diabetes mellitus adalah penyakit degeneratif yang ditandai dengan kadar gula darah sewaktu ?200 mg/dl. Penderita diabetes mellitus dianjurkan mengonsumsi serat sesuai anjuran adalah 20-35 g/hari yang berasal dari berbagai sumber bahan makanan. Minuman Kakatul adalah serbuk instan tinggi serat berasal dari kakao dan bekatul sebagai minuman yang dapat membantu menurunkan kadar glukosa dalam darah. Tujuan. Penelitian ini untuk mengetahui pengaruh pemberian minuman Kakatul terhadap kadar glukosa darah penderita DM tipe II di Puskesmas Merdeka Palembang. Metode: Jenis penelitian menggunakan rancangan quasi experiment dengan metode pre-test and post-test with two group. Indonesian translation. Polulasi penelitian ini adalah pasien diabetes melitus tipe II di Puskesmas dan jumlah sampelnya adalah 30 orang dengan kriteria kadar gulose darah 200 mg/dl.
Hasil: Rata-rata kadar glukosa sebelum perlakuan pada kelompok perlakuan yaitu 316,60 mg/dl dan 324,43 mg/dl pada kelompok pembanding. Rata-rata glukosa darah setelah perlakuan pada kelompok perlakuan sebesar 280,76 mg/dl dan pada kelompok pembanding sebesar 318,10 mg/dl. Sedangkan hasil independent sampel t-test menunjukkan selisih nilai rata-rata kadar glukosa darah kelompok perlakuan 37,93 mg/dl dan kelompok pembanding 6,33 mg/dl (p-value = 0,000).
Kesimpulan: Pemberian minuman kakatul berpengaruh terhadap glukosa darah penderita DM tipe II dengan perbedaan selisih rata-rata kadar glukosa darah kelompok perlakuan lebih tinggi dibandingkan dengan kelompok pembanding dikarenakan memiliki kandungan serat yang tinggi.
PENERAPAN UNSUR KEBARUAN (NOVELTY) BERDASARKAN UNDANG-UNDANG NOMOR 31 TAHUN 2000 TENTANG DESAIN INDUSTRI
Authors: Razak Muhammad Hendra , Riyanto Riyanto , Sunandi Andi 
Published: June 2023

Penelitian ini bertujuan untuk mengetahui Pendapat dan Putusan Majelis Hakim Pengadilan Niaga pada Pengadilan Negeri Surabaya Nomor 02/HKI.Desain Industri/2014/PN Niaga Sby. dan Mahkamah Agung Nomor 286 K/Pdt.Sus- HKI/2015 apakah telah memenuhi Prinsip/Asas/Kaidah Nasional dan Internasional dalam menilai unsur kebaruan (Novelty) desain industri. Penelitian ini dilakukan dengan menggunakan metode penelitian normatif empiris. Berdasarkan penelitian ini dapat disimpulkan bahwa Pengadilan Niaga pada Pengadilan Negeri Surabaya berpendapat bahwa penggugat bukan termasuk dalam â€œPihak yang Berkepentingan (legal standing)â€ untuk mengajukan gugatan pembatalan pendaftaran hak desain industri. Karena, yang dapat mengajukan gugatan adalah subjek hukum desain industri dalam hal ini adalah pendesain. Pengadilan Niaga pada Pengadilan Negeri Surabaya telah memenuhi ketentuan Prinsip/Asas/Kaidah Hak Kekayaan Intelektual Nasional maupun Internasional terkait pendapatnya tersebut.
Implementasi Pasal 29 Undang-Undang Nomor 36 Tahun 2009 Tentang Kesehatan Terkait Upaya Penyelesaian Sengketa Medis
Authors: Yanto Apri 
Published: June 2023

ABSTRACT
The implementation of Article 29 of Law No. 36 of 2009 concerning Health in resolving medical disputes that fall into the realm of criminal law is still very little to be used as an effort to resolve medical disputes because law enforcement still tends to choose settlement through litigation which leads to court decisions as an effort to resolve it rather than seeking penal mediation. Efforts to resolve medical disputes for health workers who commit medical malpractice according to Law Number 36 of 2009 concerning Health, the mediation route has now become one of the ways proposed by MHKI and accommodated in the latest Criminal Code to seek first settlement with a penal mediation route before entering the realm of litigation.

Keywords : Medical Dispute, Malparktek, Dispute Resolution.

ABSTRAK
Implementasi Pasal 29 Undang-Undang No 36 Tahun 2009 tentang Kesehatan dalam penyelesaian sengketa medik yang masuk pada ranah dalam hukum pidana masih sangat sedikit untuk dijadikan upaya penyelesaian sengketa medis karena penegak hukum masih cenderung memlih penyelesaian melalui litigasi yang bermuara pada putusan pengadilan sebagi upaya penyelesaiannya dari pada mengupayakan mediasi penal. Upaya penyelesaian sengketa medis bagi Tenaga kesehatan yang melakukan malpraktik medis menurut Undang-Undang Nomor 36 Tahun 2009 tentang Kesehatan jalur mediasi saat ini telah menjadi salah satu cara yang diusulkan oleh MHKI dan terakomodir dalam KUHP terbaru agar mengupayakan terlebih dahulu penyelesaian dengan jalur mediasi penal sebelum masuk kedalam ranah litigasi.
Kata Kunci : Sengketa Medis, Malparktek, Penyelesaian Sengketa
Från nära till fjärran
Authors: Lindholm Pia 
Published: June 2023

Resandet är viktigt för många idag - det är nästan en plikt att vara berest. Det ligger ett egenvärde i att besöka olika platser, att kunna införlivas i främmande sammanhang och uppleva nytt. Dagens turister har så gott som obegränsade möjligheter att förverkliga sina resedrömmar då dagens utbud av reseprodukter och -service är så rikt. I takt med att samhället har förändrats och tekniken utvecklats har också resebranschen blivit allt mer omfattande, vilket i förlängningen har präglat resandet under olika tidsperioder.
I min avhandling pro gradu koncentrerade jag mig på kategorin äldre resenärer och deras karriärer som turister, utgående från ett material bestående av 30 personers berättelser. Det centrala gällande äldre resenärer är att de har haft möjlighet att resa en längre tid och samla på sig omfattande turistkarriärer. Via detta långa perspektiv på resandet kan man få en insyn i den biografiska dimensionen av resandet, d.v.s. hur resandet har tett sig under olika perioder i livet och vilka företeelser som har påverkat resandet. I denna artikel vill jag också belysa de äldre resenärernas turistkarriärer i skenet av förändringarna i synen på människans ålder och hennes livslopp samt turismindustrins utveckling.