bluuebunny/crossref_metadata_2025_split huggingface dataset:
Compassion and engineering students' moral reasoning: The emotional experience of engineering ethics cases
Authors: Kotluk Nihat , Tormey Roland 
Published: June 2023

AbstractBackgroundThere has been an increase in interest in emotion in engineering and science ethics education. There is also evidence that emotional content in case studies may improve students' learning and enhance awareness, understanding, and motivation concerning ethical issues. Despite these potential benefits, however, emotions' relationship to moral reasoning remains controversial, with ongoing debate as to how much and in what way emotional content impacts on moral reasoning. Furthermore, only limited empirical research has explored how emotions affect students' moral reasoning in educational settings.PurposeThe purpose of this study was to determine whether mild to moderate compassion‐induced engineering ethics case contents affected the moral reasoning schemas activated in students.Design/MethodWe conducted experimental research using the Engineering and Science Issues Test (ESIT). First, we modified the six case studies of the ESIT, to increase the compassion associated with the cases' protagonists to a mild to moderate level. We tested this instrument with 207 participants to ensure the changes did affect compassion without impacting on other potential emotions. Then, in a second study with 305 participants, we investigated whether the changed compassion intensity of the protagonists in the case studies affected the moral reasoning schemas activated in participants.ResultsThe induction of mild to moderate compassion did not impact the moral reasoning schemas activated. Findings also show that we managed to affect compassion intensity in the case studies without changing other emotions.ConclusionThis study reveals how to include a targeted emotion in engineering case studies in order to improve students' learning without affecting the moral reasoning schemas activated.
Laccaria murina and L. pumila from Pakistan, a study based on SEM and nrITS molecular marker
Authors: Razzaq Fauzia , Razaq Abdul , Izhar Aiman , Zahid Omema , Rani Afifa Kainat , Khalid Abdul Nasir 
Published: June 2023

AbstractTwo species of the genus Laccaria, are described as new reports for Pakistan. Laccaria murina has been collected from a Himalayan moist temperate forest in Khanspur, KP, while L. pumila was found in the moist temperate forests of Kumrat Valley in Dir Upper, KP, and at higher altitudes of the Deosai plains of Gilgit‐Baltistan, Pakistan. Phylogenetic analysis based on the nrITS region clustered the Pakistani species with L. murina sequences with other Asian collections and L. pumila from USA and Netherlands. SEM of basidiospores along with detailed micro‐morphological data are provided. General distribution, habitat, ecology, and diagnostic features are also discussed.Research Highlights
It has new reports from Pakistan, studies based on light, scanning electron microscopy, and nrITS molecular markers.
These species have been described with detailed micro‐morphological and molecular phylogenetic analyses.
General distribution, ecology, diagnostic features, and comparisons with closely related specimens have been provided.
Graphical representation of DNA extraction and geographical locations of sampling sites are also illustrated (Figures 1 and 2).
Very few members of this genus are already described from Pakistan.
Tuberous Sclerosis Complex cell‐derived EVs have an altered protein cargo capable of regulating their microenvironment and have potential as disease biomarkers
Authors: Ní Bhaoighill Muireann , Falcón‐Pérez Juan M. , Royo Félix , Tee Andrew R. , Webber Jason P. , Dunlop Elaine A. 
Published: June 2023

AbstractHyperactivation of mechanistic target of rapamycin complex 1 (mTORC1) is a feature of many solid tumours and is a key pathogenic driver in the inherited condition Tuberous Sclerosis Complex (TSC). Modulation of the tumour microenvironment by extracellular vesicles (EVs) is known to facilitate the development of various cancers. The role of EVs in modulating the tumour microenvironment and their impact on the development of TSC tumours, however, remains unclear. This study, therefore, focuses on the poorly defined contribution of EVs to tumour growth in TSC. We characterised EVs secreted from TSC2‐deficient and TSC2‐expressing cells and identified a distinct protein cargo in TSC2‐deficient EVs, containing an enrichment of proteins thought to be involved in tumour‐supporting signalling pathways. We show EVs from TSC2‐deficient cells promote cell viability, proliferation and growth factor secretion from recipient fibroblasts within the tumour microenvironment. Rapalogs (mTORC1 inhibitors) are the current therapy for TSC tumours. Here, we demonstrate a previously unknown intercellular therapeutic effect of rapamycin in altering EV cargo and reducing capacity to promote cell proliferation in the tumour microenvironment. Furthermore, EV cargo proteins have the potential for clinical applications as TSC biomarkers, and we reveal three EV‐associated proteins that are elevated in plasma from TSC patients compared to healthy donor plasma.
Efficacy of endoscopic ultrasound‐guided abscess drainage for non‐pancreatic abscesses: A retrospective study
Authors: Tanikawa Tomohiro , Kawada Mayuko , Ishii Katsunori , Urata Noriyo , Nishino Ken , Suehiro Mitsuhiko , Kawanaka Miwa , Haruma Ken , Kawamoto Hirofumi 
Published: June 2023

AbstractBackground and AimPercutaneous drainage of intra‐abdominal abscesses is often uncomfortable for the patient and may result in prolonged hospital stays. Recent studies have shown that endoscopic ultrasound‐guided abscess drainage (EUS‐AD) could effectively treat various abscesses and fluid collections. However, no indications or procedures have been established for EUS‐AD treatments, and studies on its usefulness and safety are insufficient. The present study aimed to evaluate the efficacy and safety of EUS‐AD for treating non‐pancreatic abscesses.MethodsThis retrospective study included 20 patients, aged ≥20 years, who underwent EUS‐AD for an abscess or fluid accumulation in the abdomen or mediastinum, but not the pancreas. Patients were treated at the Kawasaki University General Medical Center between March 2013 and June 2021. All EUS‐AD procedures were performed prior to a percutaneous drainage or surgical drainage.ResultsAmong the 20 patients who underwent an EUS‐AD for abscess, 8 (40%) had liver abscesses, 6 (30%) had intraperitoneal abscesses, 3 had (15%) splenic abscesses, 1 (5%) had a mediastinal abscess, 1 (5%) had an iliopsoas abscess (n = 1, 5%), and 1 (5%) had an abdominal wall abscess. The technical success rate was 95% (n = 19/20). We inserted nasobiliary catheters in 4/20 patients (20%). The clinical success rate was 90% (n = 18/20). Two clinical failures required reintervention, and both were treated with percutaneous drainage. Adverse events were observed in 2/20 patients (10%). One patient experienced fever after the procedure, and the other experienced localized peritonitis.ConclusionEUS‐AD was effective and safe for abscess removal, particularly when approached from the upper gastrointestinal tract.
Integrating 3HP‐based tuberculosis preventive treatment into Zimbabwe's Fast Track HIV treatment model: experiences from a pilot study
Authors: Mapingure Munyaradzi P. , Zech Jennifer M. , Hirsch‐Moverman Yael , Msukwa Martin , Howard Andrea A. , Makoni Tatenda , Gwanzura Clorata , Apollo Tsitsi , Sandy Charles , Musuka Godfrey N. , Rabkin Miriam 
Published: June 2023

AbstractIntroductionTuberculosis (TB) causes one‐third of HIV‐related deaths worldwide, making TB preventive treatment (TPT) a critical element of HIV programmes. Approximately 16% of people living with HIV (PLHIV) on antiretrovirals in Zimbabwe are enrolled in the Fast Track (FT) differentiated service delivery model, which includes multi‐month dispensing of antiretrovirals and quarterly health facility (HF) visits. We assessed the feasibility and acceptability of utilizing FT to deliver 3HP (3 months of once‐weekly rifapentine and isoniazid) for TPT by aligning TPT and HIV visits, providing multi‐month dispensing of 3HP, and using phone‐based monitoring and adherence support.MethodsWe recruited a purposive sample of 50 PLHIV enrolled in FT at a high‐volume HF in urban Zimbabwe. At enrolment, participants provided written informed consent, completed a baseline survey, and received counselling, education and a 3‐month supply of 3HP. A study nurse mentor called participants at weeks 2, 4 and 8 to monitor and support adherence and side effects. When participants returned for their routine 3‐month FT visit, they completed another survey, and study staff conducted a structured medical record review. In‐depth interviews were conducted with providers who participated in the pilot.ResultsParticipants were enrolled between April and June 2021 and followed through September 2021. Median age = 32 years (IQR 24,41), 50% female, median time in FT 1.8 years (IQR 0.8,2.7). Forty‐eight participants (96%) completed 3HP in 13 weeks; one completed in 16 weeks, and one stopped due to jaundice. Most participants (94%) reported “always” or “almost always” taking 3HP correctly. All reported they were very satisfied with the counselling, education, support and quality of care they received from providers and FT service efficiency. Almost all (98%) said they would recommend it to other PLHIV. Challenges reported included pill burden (12%) and tolerability (24%), but none had difficulty with phone‐based counselling or wished for additional HF‐based visits.DiscussionUsing FT to deliver 3HP was feasible and acceptable. Some reported tolerability challenges but 98% completed 3HP, and all appreciated the efficiency of aligning TPT and HIV HF visits, multi‐month dispensing and phone‐based counselling.ConclusionsScaling up this approach could expand TPT coverage in Zimbabwe.
Quantitative Assessment of Myocardial Edema by MR T2 Mapping in Children With Kawasaki Disease
Authors: Hu Lei , A‐zhe Shi‐gan‐mo , Zhou Zhong‐qin , Zhang Nan‐jun , Peng Sheng‐kun , Wang Chuan , Guo Ying‐kun , Wen Ling‐yi 
Published: June 2023

BackgroundFew studies assessed myocardial inflammation using Cardiovascular Magnetic Resonance Imaging in Kawasaki disease (KD) patients.PurposeTo quantify myocardial edema in KD patients using T2 mapping and explore the independent predictors of T2 values.Study TypeProspective.SubjectsNinety KD patients including 40 in acute phase (26 males, 65.0%) and 50 in chronic phase (34 males, 68.0%). Thirty‐one healthy volunteers (21 males, 70.0%).Field Strength/Sequence3.0 T T2‐weighted Turbo Spin Echo‐Short Time of Inversion Recovery sequence, True fast imaging with steady precession flash sequence and fast low‐angle shot 3D spoiled gradient echo sequence.AssessmentT2 values were compared among KD groups and controls.Statistical TestStudent's t test and Fisher's exact test; One‐way analysis of variance; Pearson correlation analysis; Receiver operating curve analysis; Multivariable linear regression.ResultsGlobal T2 value of KD patients in acute phase was the highest, followed by those of chronic‐phase patients and controls (38.83 ± 2.41 msec vs. 37.55 ± 2.28 msec vs. 36.05 ± 1.64 msec). Regional T2 values showed a same trend. There were no significant differences in global and regional T2 values between KD patients with and without coronary artery (CA) dilation, no matter in acute or chronic phase (all KD patients: P = 0.51, 0.51, 0.53, 0.72; acute KD: P = 0.61, 0.37, 0.33, 0.83; chronic KD: P = 0.65, 0.79, 0.62, 0.79). No significant difference was observed in global T2 values between KD patients with Z score > 5.0 and 2.0 < Z score ≤ 5.0 (P = 0.65). Multivariate analysis demonstrated that stage of disease (β = −0.123) and heart rate (β = 0.280) were independently associated with global T2 values.Data ConclusionThe degree of myocardial edema was more severe in acute‐phase than in chronic‐phase KD patients. Myocardial edema persists in patients regardless of the existence or degree of CA dilation.Evidence Level2Technical EfficacyStage 2
Deconstructing SARS‐CoV‐2 neutralization: A modular molecular framework for computational design and comparison of antibodies and nanobodies targeting the spike RBD
Authors: Tragni Vincenzo , Mercurio Ivan , Paoletti Diletta Pia , Onofrio Angelo , Laera Luna , Cafferati Beltrame Lucas , Sgobba Maria Noemi , Guerra Lorenzo , Volpicella Mariateresa , De Grassi Anna , Elia Gabriella , Pierri Ciro Leonardo 
Published: June 2023

AbstractSince 2020 the COVID‐19 pandemic has led scientists to search for strategies to predict the transmissibility and virulence of new severe acute respiratory syndrome coronavirus 2 variants based on the estimation of the affinity of the spike receptor binding domain (RBD) for the human angiotensin‐converting enzyme 2 (ACE2) receptor and/or neutralizing antibodies. In this context, our lab developed a computational pipeline to quickly quantify the free energy of interaction at the spike RBD/ACE2 protein–protein interface, reflecting the incidence trend observed in the transmissibility/virulence of the investigated variants. In this new study, we used our pipeline to estimate the free energy of interaction between the RBD from 10 variants, and 14 antibodies (ab), or 5 nanobodies (nb), highlighting the RBD regions preferentially targeted by the investigated ab/nb. Our structural comparative analysis and interaction energy calculations allowed us to propose the most promising RBD regions to be targeted by future ab/nb to be designed by site‐directed mutagenesis of existing high‐affinity ab/nb, to increase their affinity for the target RBD region, for preventing spike‐RBD/ACE2 interactions and virus entry in host cells. Furthermore, we evaluated the ability of the investigated ab/nb to simultaneously interact with the three RBD located on the surface of the trimeric spike protein, which can alternatively be in up‐ or down‐ (all‐3‐up‐, all‐3‐down‐, 1‐up‐/2‐down‐, 2‐up‐/1‐down‐) conformations.
Development of antioxidant and smart NH3‐sensing packaging film by incorporating bilirubin into κ‐carrageenan matrix
Authors: Liu Yingnan , Tong Fei , Xu Yingran , Hu Yunyun , Liu Wenya , Yang Zan , Yu Zhenyu , Xiong Guoyuan , Zhou Yibin , Xiao Yaqing 
Published: June 2023

AbstractBACKGROUNDActive and smart food packaging based on natural polymers and pH‐sensitive dyes as indicators has attracted widespread attention. In the present study, an antioxidant and amine‐response color indicator film was developed by incorporating bilirubin (BIL) into the κ‐carrageenan (Carr) matrix.RESULTSIt was found that the introduction of BIL had no effect on the crystal/chemical structure, water sensitivity and mechanical performance of the Carr‐based films. However, the barrier properties to light and the thermal stability were significantly improved after the addition BIL. The Carr/BIL composite films exhibited excellent 1,1‐diphenyl‐2‐picryl‐hydrazyl (i.e. DPPH)/2,2′‐azino‐bis‐(3‐ethylbenzothiazoline‐6‐sulfonic acid) (i.e. ABTS) free radical scavenging abilities and color responsiveness to different concentrations of ammonia. The application assay reflected that the Carr/BIL0.0075 film was effective in delaying the oxidative deterioration of shrimp during storage and realizing the color response of its freshness through the change of b* value.CONCLUSIONActive and smart packaging films were successfully prepared by incorporating different contents of BIL into the Carr matrix. The present study helps to further encourage the design and development of a multi‐functional packaging material. © 2023 Society of Chemical Industry.
Associations among posttraumatic growth, demographic characteristics, posttraumatic stress symptoms, and trauma type, with a focus on sexual violence
Authors: Jónsdóttir Erla Katrín , Sigurvinsdottir Rannveig S. , Ásgeirsdóttir Bryndís Björk 
Published: June 2023

AbstractThis study assessed posttraumatic growth (PTG) across multiple trauma types and by demographic characteristics (i.e., sex, age, education). Moreover, we examined the association between PTG and posttraumatic stress disorder (PTSD) symptoms as well as the characteristics and predictors of PTG after sexual violence. A phone survey was conducted in a nationally representative sample of 1,766 Icelandic adults. In total, 1,528 individuals reported having experienced some form of trauma and were included in the analysis, and 563 reported experiencing sexual violence. Interpersonal trauma (e.g., sexual violence, emotional abuse, and domestic violence) was associated with the highest levels of PTG. Moderate levels of PTSD symptoms were associated with the highest levels of PTG, whereas high‐ or low‐level PTSD symptoms were related to less PTG. Women reported significantly more PTG than men, d = 0.16 and survivors of sexual violence reported significantly more PTG than individuals who reported other forms of trauma exposure, d = 0.28. Among sexual violence survivors, no demographic factors were associated with PTG, but cumulative trauma and positive social reactions were significantly related to higher levels of PTG. This study highlights that personal growth can result from aversive experiences and suggests a curvilinear association between PTG and PTSD symptoms.
New capacities and enhanced research agenda for science: Exploring relational cooperation with industry
Authors: Verre Vladimiro , Milesi Darío , Petelski Natalia 
Published: June 2023

AbstractThe effects that cooperation with industry generates in public research depend on the specific collaboration scheme. Joint research and research service share some features, such as the frequency and intensity of interactions and knowledge based exchanges, which allow them to be considered as relational schemes. This work investigates the effects that such schemes generate in public research, based on the contributions that industry makes and the way in which they are linked to public learning and the direction of research agenda. A case study is carried out in three sectors, agrobiotechnology, biopharmaceutical and nanotechnology, from a developing country like Argentina, which covers R&D projects included in both schemes. Among the main findings, it is highlighted that, regardless of the intensity of knowledge of the industrial contribution, it can induce in public researchers both learning dynamics and feedback on more basic aspects of their activity. Likewise, industrial contributions in the conception stage of the project make the public applied research agenda expand toward more relevant topics from the economic and social point of view. Finally, industry's knowledge contributions in the laboratory phase, scale change and regulatory aspects, allow public researchers to absorb new for them capacities.
Engineering Quantum Nanophotonic Components from Hexagonal Boron Nitride
Authors: Nonahal Milad , Li Chi , Ren Haoran , Spencer Lesley , Kianinia Mehran , Toth Milos , Aharonovich Igor 
Published: June 2023

AbstractIntegrated quantum photonics (IQP) provides a path to practical, scalable quantum computation, communications and information processing. Realization of an IQP platform requires controlled engineering of many nanophotonic components. However, the range of materials for monolithic platforms is limited by the simultaneous need for high‐quality quantum light sources, high optical performance, and availability of scalable nanofabrication techniques. Here, the fabrication of IQP components from the recently emerged material hexagonal boron nitride (hBN), including tapered waveguides, microdisks, and 1D and 2D photonic crystal cavities, is demonstrated. Resonators with quality factors greater than 4000 are achieved, and proof‐of‐principle complex, free‐standing IQP circuitry fabricated from single‐crystal hBN is engineered. The results show the potential of hBN for scalable integrated quantum technologies.
Carbon steel corrosion in a bentonite buffer: A comparison between in situ exposure and lab based experiments
Authors: Hesketh James , Haynes Haydn , Reddy Bharti , Rance Andy , Bevas Clayton , Padovani Cristiano , Diomidis Nikitas 
Published: June 2023

AbstractIn this paper, carbon steel corrosion rates from experiments performed in situ (performed in an underground rock laboratory) and ex situ (performed in a conventional laboratory) test methods in anaerobic saturated bentonite are compared. The results indicate that the long‐term corrosion rate follows a power law decay curve, with a higher initial rate and greater rate of decay at higher temperature. In compacted bentonite blocks, varying the density has no significant effect on the corrosion rate measured during in situ testing, whereas granular bentonite of an equal dry density leads to a higher corrosion rate. Precorrosion of test specimens in an aerated solution at room temperature has a negligible effect on the subsequent anaerobic corrosion rate when tested ex situ for durations up to 11.8 years. The main difference between in situ and ex situ tests is the formation of silicon‐rich corrosion products in the ex situ tests but not in the in situ tests. Despite these differences, the corrosion rates in both tests exhibit the same general temporal evolution and similar magnitudes, suggesting that the main steel degradation processes are maintained in both configurations.
3D‐Printed Inherently Porous Structures with Tetrahedral Lattice Architecture: Experimental and Computational Study of Their Mechanical Behavior
Authors: Kuzina Maria A. , Kurpiers Chantal M. , Tsai Ya‐Yun , Schwaiger Ruth , Chang Shu‐Wei , Levkin Pavel 
Published: June 2023

AbstractIncreasing demand in automotive, construction, and medical industries for materials with reduced weight and high mechanical durability has given rise to porous materials and composites. Materials combining nano‐ and microporosity and a well‐defined cellular macroporous architecture offer great potential weight reduction while maintaining mechanical durability. To achieve predictable mechanical performance, it is essential to apply experimental and computational efforts to precisely describe material structure–properties relationships. This study explores polymer structures with polymerization‐inherited porosity and well‐defined macroporous geometry, fabricated via digital light processing (DLP) 3Dprinting. Pore size and relative density are varied by ink composition and printing parameters to track their influence on the structure stiffness. Simulated stiffness values for the base polymer correspond to the experimentally determined elastic properties, showing Young's moduli of 554–722 MPa depending on the cosolvent ratio, which confirms the structure–properties relationship. Macroporosity is introduced in the form of a 3D tetrahedral bending‐dominated architecture with the resulting specific Young's moduli of 79.5 MPa cm3 g−1, comparable to foams. To merge the gap in stiffnesses, further investigation of structure–property relationships of various 3D–printed lattice architectures, as well as its application to other stereolithography methods to eliminate the negative effects from printing artifacts and resolution limit of the DLP 3D‐printing, are envisioned.