bluuebunny/crossref_metadata_2025_split huggingface dataset:
Meta-analysis of the Modified Checklist for Autism in Toddlers, Revised/Follow-up for Screening
Authors: Aishworiya Ramkumar , Ma Van Kim , Stewart Susan , Hagerman Randi , Feldman Heidi M. 
Published: May 2023

CONTEXT
The Modified Checklist for Autism in Toddlers, Revised with Follow-up (M-CHAT-R/F) is used worldwide to screen for autism spectrum disorder (ASD).

OBJECTIVE
To calculate psychometric properties of the M-CHAT-R/F for subsequent diagnosis of ASD.

DATA SOURCES
Systematic searches of Medline, Embase, SCOPUS, and Trip Pro databases from January 2014 to November 2021.

STUDY SELECTION
Studies were included if they (1) used the M-CHAT-R/F (2) applied standard scoring protocol, (3) used a diagnostic assessment for ASD, and (4) reported at least 1 psychometric property of the M-CHAT-R/F.

DATA EXTRACTION
Two independent reviewers completed screening, full-text review, data extraction, and quality assessment, following Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines. A random-effects model was used to derive pooled estimates and assess for between-study heterogeneity.

RESULTS
Of 667 studies identified, 15 with 18 distinct samples from 10 countries (49 841 children) were used in the meta-analysis. Pooled positive predictive value (PPV), was 57.7% (95% confidence interval [CI] 48.6–66.8, τ2 = 0.031). PPV was higher among high-risk (75.6% [95% CI 66.0–85.2]) than low-risk samples (51.2% [95% CI 43.0–59.5]). Pooled negative predictive value was 72.5% (95% CI 62.5–82.4 τ2 = 0.031), sensitivity was 82.6% (95% CI 76.2–88.9) and specificity 45.7% (95% CI 25.0–66.4).

LIMITATIONS
Negative predictive value, sensitivity, and specificity were calculated based on small sample sizes because of limited or no evaluation of screen-negative children.

CONCLUSIONS
These results support use of the M-CHAT-R/F as a screening tool for ASD. Caregiver counseling regarding likelihood of an ASD diagnosis after positive screen should acknowledge the moderate PPV.
Inyección percutánea de etanol en el bocio multinodular no tóxico benigno
Authors: Lorda Lázaro , Igarza Jacinto Oscar Navas , Gómez Osvaldo Miranda , Campa Belkis Ortega de la , López Henry Pérez 
Published: May 2023

Introducción: El bocio multinodular no tóxico benigno es una de las enfermedades endocrinas más comunes que afectan a la población actual, y es a su vez la enfermedad endocrina que con mayor frecuencia requiere intervención quirúrgica.
Objetivo: Mostrar los resultados de la inyección percutánea de etanol en el tratamiento de pacientes con bocio multinodular no tóxico benigno a corto y mediano plazo.
Métodos: Se realizó un estudio longitudinal, prospectivo, en pacientes con bocio multinodular no tóxico benigno, tratados con inyección percutánea de etanol. Las variables categóricas se describieron por frecuencias absolutas y porcentajes y para las numéricas se calculó la media, la desviación estándar, así como el valor mínimo y el máximo. Para evaluar los cambios entre los volúmenes inicial y final de los nódulos se utilizó la prueba t de Student para muestras relacionadas.
Resultados: La media del por ciento de reducción del volumen de los nódulos fue de 48,23 ± 9,55; 58,05 ± 11,79 y 69,49 ± 13,11; al mes, 3 meses y 6 meses de realizado el tratamiento respectivamente. El éxito clínico fue completo en el 67,3 %, 75,5 % y el 87,8 % de los pacientes, al mes, 3 meses y 6 meses de seguimiento post tratamiento respectivamente. No se presentaron complicaciones.
Conclusiones: La inyección percutánea de etanol es una alternativa a la cirugía para el tratamiento de los pacientes con bocio multinodular no tóxico benigno, es segura, efectiva, con efectos adversos transitorios y complicaciones muy poco frecuentes a corto y mediano plazo.
Effects of the CB1 receptor antagonists AM6545 and AM4113 on metabolic syndrome-induced prostatic hyperplasia in rats
Authors: Eid Basma G. , Neamatallah Thikryat , Binmahfouz Lenah S. , Bagher Amina M. , Alamoudi Abdulmohsin J. , Aldawsari Hibah Mubarak , Hanafy Abeer , Hasan Atif , El-Bassossy Hany M. , Abdel-Naim Ashraf B. , Vemuri Kiran , Makriyannis Alexandros 
Published: May 2023

Metabolic syndrome (MetS) is a combination of metabolic disorders that can predispose individuals to benign prostatic hyperplasia (BPH). The inhibition of the cannabinoid 1 (CB1) receptor has been used to treat metabolic disorders in animal models. This study reports the use of a peripherally restricted CB1 antagonist (AM6545) and a neutral CB1 antagonist (AM4113) to improve MetS-related BPH in rats. Animals were divided into three control groups to receive either a normal rodent diet, AM6545, or AM4113. MetS was induced in the fourth, fifth, and sixth groups using a concentrated fructose solution and high-salt diet delivered as food pellets for eight weeks. The fifth and sixth groups were further given AM6545 or AM4113 for additional four weeks. Body and prostate weights were measured and prostate sections were stained with haematoxylin eosin. Cyclin D1, markers of oxidative stress and inflammation, and levels of the endocannabinoids were recorded. BPH in rats with MetS was confirmed through increased prostate weight and index, as well as histopathology. Treatment with either AM6545 or AM4113 significantly decreased prostate weight, improved prostate histology, and reduced cyclin D1 expression compared with the MetS group. Groups treated with CB1 antagonists experienced reduced lipid peroxidation, recovered glutathione depletion, restored catalase activity, and had lower inflammatory markers interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF-α). MetS rats treated with either AM6545 or AM4113 showed reduced concentrations of anandamide (AEA) and 2-arachidonoylglycerol (2-AG) in the prostate compared with the MetS group. In conclusion, the CB1 antagonists AM6545 and AM4113 protect against MetS-induced BPH through their anti-proliferative, antioxidant, and anti-inflammatory effects.
Rupture Directivity of the 25 October 2022 Mw 5.1 Alum Rock Earthquake
Authors: Hirakawa Evan , Parker Grace A. , Baltay Annemarie , Hanks Thomas 
Published: May 2023

Abstract
The 25 October 2022 Mw 5.1 Alum Rock earthquake shows strong evidence for southeast rupture directivity along the central Calaveras fault (CCF), as indicated by observed ground motions and simulated kinematic ruptures. Peak ground accelerations (PGAs) and peak ground velocities (PGVs) are notably higher to the southeast, with an order of magnitude difference for stations at the same distance but different azimuths. In addition, PGAs are lower than that predicted by ground-motion models by a factor of 3 on average in all the directions, indicating a low stress drop (∼1.57 MPa). Directivity function modeling and ground-motion simulations both indicate rupture propagation to the southeast with rupture velocity between 2.3 and 2.5 km/s. We suggest that the southward rupture propagation and relatively low stress drop may be typical of M ∼5 earthquakes on this portion of the CCF.
Three cases of Actinomyces isolation from the eye lesions of patients with a chronic and recurrent ophthalmic infection
Authors: Kirti Madhavi , Sharma Bhawna , Gajashree Samikkunnu 
Published: May 2023

Actinomycosis is an indolent, slowly progressive infection caused by Gram-positive facultative anaerobic bacteria from the genus Actinomyces. These bacteria have been reported as a cause of ophthalmic infections such as endophthalmitis, keratitis, and canaliculitis. The objective of the present study was to investigate the pattern and antibiotic sensitivity profile of anaerobes isolated from lesions in the medial canthus of the eye.
Three pus aspirate samples (from eye) were delivered to a microbiology laboratory in a strict anaerobic condition in Robertson Cooked Meat media (RCM). The samples were inoculated on Blood Agar and incubated anaerobically in a Gas Pack Jar incubator at 5%-10% CO2 and in aerobic condition at 37°C. Pure colonies isolated on anaerobically incubated plates were identified by the VITEK® 2 COMPACT system. Antibiotic sensitivity testing was conducted using an Epsilometer-strip test.
Three isolates identified and confirmed with the help of VITEK® 2 were Actinomyces israelii, Actinomyces odontolyticus, and Actinomyces meyeri. All three species of Actinomyces were sensitive to Vancomycin, Moxifloxacin, and Imipenem, but they were resistant to Metronidazole.
Since there have been several cases of anaerobic ophthalmic infections reported to date, samples from patients with chronic eye infections should be analyzed for anaerobic culture for correct diagnosis and proper treatment. Moxifloxacin but not Metronidazole is a suitable drug for the treatment of anaerobic eye infection.
ORALIDADE, ARGUMENTAÇÃO E TECNOLOGIAS DIGITAIS NO PROJETO POLÊMICAS EM DEBATE
Authors: Batista Júnior José Ribamar Lopes , Peixoto Gercivaldo Vale 
Published: May 2023

O Polêmicas em Debate visa sanar a dificuldade de estudantes do Ensino Médio em argumentar a partir de situações relacionadas ao mundo do trabalho e exercício da cidadania. Neste trabalho, apresentamos resultados das edições realizadas nos anos de 2020 a 2022. Alicerçado no conceito de letramento (BARTON, 2007), o projeto é composto por seis etapas, após o qual espera-se que os discentes tenham incremento na capacidade argumentativa, compreensão social e desenvolvimento ético. Os resultados demonstram que o projeto promove a integração dos alunos com os debates atuais e geram a melhoria da autopercepção como cidadãos detentores de voz e protagonismo.
Chronic Intramedullary Spinal Cord Abscess Mimicking Intramedullary Spinal Cord Tumor—“Phantom Tumor”
Authors: Kothari Ajay Ramesh , Katkade Siddharth Manik , Kaparthi Sughandh , Sancheti Parag Kantilal 
Published: May 2023

Case:
A 33-year-old woman with back pain and radiculopathy had presented with bilateral ankle weakness. MRI showed an intramedullary conus lesion suggestive of neoplasm, but posterior midline durotomy revealed only pus. Pus samples showed Staphylococcus aureus, which was treated with 6 weeks of antibiotics. Two-year follow-up showed complete neurological recovery with no clinicoradiological signs of recurrence.

Conclusion:
Usually, intramedullary spinal cord abscess (ISCA) has an acute presentation and warrants an emergent line of treatment with a risk of mortality. Very rarely chronic ISCA can mimic intramedullary spinal cord tumor. It is the first case reported in the literature of chronic ISCA mimicking conus IMST.
A Novel Technique for Lateral Ankle Ligament Reconstruction with Total Ankle Total Talus Replacement
Authors: Tabarestani Troy Q. , Anastasio Albert T. , Lukosius Eric Z. , Schweitzer Karl M. 
Published: May 2023

Case:
A 65-year-old man with severe left talar avascular necrosis, arthritis, and chronic lateral ankle instability underwent total ankle total talus replacement (TATTR) with lateral ligament reconstruction. Tibial component placement was performed using preoperative computed tomography navigation and patient-specific guides. A custom, total talus replacement to mate with the fixed-bearing tibial component was implanted. Last, a modified Brostrom procedure was performed to restore lateral ankle stability. The patient has performed well through 1 year with improved pain-free function.

Conclusion:
This case report details a novel technique for performing a modified Brostrom procedure in conjunction with TATTR to restore lateral ankle stability.
analisis keputusan muzakki melaksanakan pembayaran zakat di badan amil zakat nasional kabupaten di sumatera utara
Authors: Hasibuan Siti Masitoh 
Published: May 2023

Artikel ini mendiskusikan tentang kepercayaan muzakki terhadap badan amil zakat nasional yang menuntut adanya kesadaran. Tujuan dari penelitian ini adalah untuk mengetahui penngaruh langsung dan tidak langsung antara variabel pengetahuan, religiusitas, ulama, transparansi dan kepercayaan sebagai variabel interveningterhadap keputusan muzakki melaksanakan pembayaran zakat melalui baznas kabupaten di Sumatera Utara. Metode penelitian ini menggunakan pendekatan kuantitatif dengan jalur dan menggunakan bantuan program SPSS. Dari hasil uji signifikansi diperoleh pengetahuan dan transparansi berpengaruh signifikan dan nyata terhadap keputusan membayar zakat melalui badan amil zakat nasional kabupaten melalui kepercayaan sebagai variabel intervening di Sumatera Utara. Religiusitas dan ulama tidak berpengaruh signifikan dan nyata terhadap keputusan membayar zakat melalui badan amil zakat nasional kabupaten melalui kepercayaan sebagai variabel intervening di Sumatera Utara dengan tingkat kepercayaan 95% atau tingkat kesalahan sebesar 5 %.
A Comparative Study between Ali bin Abi Thalib Islamic Institute and Badr Al-Saleh Purwoasri Islamic Institute for the Arabic Language/ دراسة مقارنة بين معهد علي بن أبي طالب ومعهد بدر الصالح فورواأسري في اللغة العربية
Authors: Naufal Ahmad 
Published: May 2023

تهدف هذا البحث إلى معرفة كفاءة الطلاب في مهارات اللغة العربية المنتجة ، يعني مهارة الكلام ومهارة الكتابة ، وكيف تفوق طلاب السنة الثالثة في معهد علي بن أبي طالب الإسلامية بسورابايا على طلاب الصف الثالث في معهد بدر الصالح فورواأسري بكديري. في هاتين المهارتين وبصرف النظر عن الطلاب في معهد علي بن طالب إسلامية بسورابايا، في معهد علي بن أبي طالب الإسلامية بسورابايا ، هناك طلاب من المدرسة الحكومية (SMA) ، أي من لم يتعلم اللغة العربية، أو من غير المعهد الذي يهتم بتعليم اللغة العربية. وأما في معهد بدر الصالح فورواأسري بكديري أكثر الطلاب من المعاهد التي يهتم بتعليم اللغة العربية والدراسة الإسلامية. من الاستقراء الذي بستخدمه الباحث في هذا البحث العلمي هو دراسة الحالة ، وكانت المداخل التي استخدمها الباحث في هذا البحث هي المدخل الكيفي والمدخل الكيمي. ومهارة التي اختار الباحث في هذا البحث هي المهارات الإنتاجية يعني مهارة الكلام ومهارة الكتابة.الكلمات الرئيسية: الطلاب، دراسة مقارنة، مهارة الكلام, مهارة الكتابة
Efficacy of vitamin D supplementation and metformin compared to metformin alone in infertile females with polycystic ovary syndrome: a randomized open label trial.
Authors: Rehman Rehana , Naz Sumaira , Khan Haq Nawaz , Sheikh Aisha , Azhar Arfa , Ashraf Mussarat , Afzal Shaista , Khan Aysha Habib 
Published: May 2023

Abstract
Background: WHO has declared Infertility as the fifth-highest serious global disability with prevalence of approximately 22% in Pakistan; 80% due to polycystic ovarian syndrome (PCOS). PCOS is characterized by “the presence of any two out of three criteria, that is oligo and/or anovulation, excess androgen activity and/or polycystic ovarian morphology on ultrasound”. Vitamin D deficiency (VDD) [serum 25(OH) D <20 ng/ml] is vital for female health and becoming public health problem even in sun-drenched cities. With high prevalence (58%) of VDD in Pakistani PCOS. The hypothesis: “VD supplementation can improve fertility by correcting in IR, ovulatory dysfunction, endometrial thickness and hyperandrogenism in primary infertile PCOS patients of our population”.
We aim to evaluate impact of oral VD supplementation on fertility potential of VDD PCOS (VD <20 ng/ml) in a 2-years randomized clinical trial; Group-1 VDD control PCOS (n=100) and Group-2 VDD intervention group (n=100). Group-1will receive 1.5 g/day metformin therapy for 24 weeks. Group-2 will be given 50,000 I.U of VD once weekly for 8 weeks, followed by 50,000 I.U once every fortnight from 9- 24 weeks plus metformin therapy.
Impact will be assessed by comparing trans-vaginal ultrasound (TVS; Day 12) at the start with TVS at end point (24 weeks) to observe change in dominantfollicle size (≥14 mm) and endometrial thickness (≥8 mm).
Discussion: The proposed interventions will help to evaluate the impact of vitamin D supplementation on follicular maturation and endometrial thickness and PCOS parameters including lipid index and insulin resistance.
Trial registration: ClinicalTrials.gov, NCT03989778
Application of Time Series Analysis to Vendor Selection Problem:
A Problem of Multi-Objective Decision Making
Authors: Gupta Srikant , Gupta Neha , Kamal Murshid , Vijayvargy Lokesh 
Published: May 2023

Abstract
The attainment of a competitive advantage can be facilitated by the presence of a vendor who is both effective and efficient. The process of selecting a vendor is a complex decision-making task that entails consideration of multiple quantitative and qualitative factors. The objective of this study is to minimise the net ordering cost, transportation cost, and late deliveries. When examining the various circumstances of existence, it is impossible to make anticipatory prognostications. The utilisation of Interval type-2 trapezoidal fuzzy numbers has been employed to effectively demonstrate the presence of uncertainty in the input parameters. A precise equivalent form has been derived through the calculation of the expected value. Exponential smoothing forecasting analysis has been utilised to ascertain the precise demand for the product in order to mitigate the risk of shortages and consequent financial losses. Ultimately, an effective methodology utilising fuzzy goal programming has been employed to attain a mutually satisfactory solution. The proposed methodology has been elucidated through the addition of a numerical illustration of its underlying concepts.
Digital media use and the Chinese elderly’s physical activity: Evidence from a national aging social survey
Authors: Zhang Yunliang , Chen Gaoran , Qi Shaojie 
Published: May 2023

Abstract
Background and Objectives: Constructing a national fitness service system is important in realizing high-quality development. This study analyze the impact and mechanism of digital media use on physical activity (PA) in the elderly.
Research Design and Methods: This study uses the China Longitudinal Aging Social Survey data. At first, we uses the ordinary least square model (OLS) and binary selection modelto test the relationship between digital media use and elderly’s PA.Then, we uses the three-step causal analysis and Bootstrap methods to test whether there is a mediating effect.
Results: The study found that: first, physical activity of the elderly involves multiple difficulties, such as lack of PA venues, PA organizations and PA guidance. Second, the use of digital media such as smartphones and the internet have a positive impact on the elderly’s PA, and this conclusion still holds after using multiple robustness tests. Thirdly, promoting the elderly’s participation in community governance, enhancing interpersonal support of the elderly, and improving positive efficacy of the elderly are mediating mechanisms.
Discussion and Implications: This study highlights the importance of using digital media, upgrading sports public service resources, participating in community governance, and building social support for the elderly.
Geotechnical Characteristics and Seismic stability Evaluation of Pumice-fall Deposits Soil on Collapse Slope by the 2018 Hokkaido Eastern Iburi earthquake
Authors: KAWAJIRI Shunzo , Watanabe Tatsuya , Yamaguchi Kohei , Minabe Yuki , Nakamura Dai , Kawaguchi Takayuki , Yamashita Satoshi 
Published: May 2023

Abstract
The September 6, 2018, earthquake in the eastern part of Hokkaido, Japan, caused extensive slope failures in Atsuma-town, Hokkaido, Japan. In this study, the authors performed in-situ investigations, including trenching and portable dynamic cone penetration tests, on weathered fallen pumice sediments, which are one of the causes of the slope failures. In addition, we performed direct box shear tests on undisturbed samples collected from an undisturbed area under various shear conditions to characterize mechanical properties of the soil. The parameters obtained from the mechanical tests were used to evaluate slope stability under normal and seismic conditions with an infinite-length slope model. The results showed that the slopes where seismic failures occurred had a fragile layer from the surface to a depth of approximately 1.5 m, which generally corresponded to the depth of failure. Weathered pumice deposits with extremely high water content existed at the boundary between the weak layer and the basement layer, and their shear strength was velocity dependent. It has been shown that an infinite-length slope stability analysis can be performed by using mechanical parameters for which velocity dependence of horizontal acceleration and shear strength due to seismic motion are accounted for.
Sustainable regional biogas networks in Southern Brazil
Authors: Schmedeman Phillip , Rajasekaran Karthik , Siddiqi Afreen , Junge Cristian , Tan Chun Hern , Lofhagen Janaina , Marques Felipe , de Weck Olivier 
Published: May 2023

Abstract
Biogas production from livestock manure has been implemented on large farms in many regions for generating energy while curbing air and water pollution that otherwise results from untreated manure. Traditional biogas systems have required subsidies for implementation on large farms, while implementation on small farms remains rare. Using a new non-linear optimization model with validated field data from Southern Brazil, we explore the feasibility of manure-to-energy systems with cooperative collection and energy production. We generate technical designs for several regions while accounting for costs and greenhouse gas emissions. Our results indicate that profitable and environmentally responsible biogas networks are possible for the areas studied. In one case, a consortium of 26 municipalities in Parana, Brazil, may generate 718 million m3 of biomethane while offsetting 10.5 billion kg of CO2 equivalent greenhouse gas annually, with profits up to US$250 million. Results show that municipality-level biomethane production is more profitable than electricity generation and highlight the need for concurrent policy and technical design for enabling viable biomass to energy systems.
Effect of preoperative oral rehydration before cesarean section on ultrasound assessment of gastric volume and intraoperative hemodynamic changes: a randomized controlled trial
Authors: Ijiri Eriko. , Mori Chie. , Sasakawa Tomoki. 
Published: May 2023

Abstract
Background
Cesarean section often requires an urgent transfusion load due to decreased blood pressure after spinal anesthesia. This prospective randomized study aimed to investigate whether a preoperative oral rehydration solution (ORS) stabilized perioperative circulatory dynamics.
Methods
Sixty-three parturients scheduled for cesarean section under combined spinal epidural anesthesia (CSEA) were randomly allocated to one of three groups: Group O received 500 mL ORS before bedtime and 500 mL 2 h before CSEA, Group M received mineral water instead of ORS, and Group C had no fluid intake (controls). After entering the operating room, stomach size was measured using ultrasound. Blood samples were obtained, and CSEA was induced. Vasopressors were administered when systolic blood pressure was < 90 mmHg or decreased by > 20%. In addition, phenylephrine (0.1 mg) was administered when the heart rate was ≥ 60 bpm, or ephedrine (5 mg) at < 60 bpm. The primary outcome was the total vasopressor dose administered. Secondary outcomes were the cross-sectional area of the stomach antrum, maternal plasma glucose levels, serum sodium levels, total intravenous fluid, bleeding volume, urine volume, operative time, and cord blood gas values after delivery.
Results
The total vasopressor dose was lower in Group O than in Group C (P < 0.05). Group O had lower total dose of phenylephrine than Group C (P < 0.05). There were no significant differences between Group M and other groups. No differences were detected regarding secondary outcomes.
Conclusions
In women scheduled for cesarean section, preoperative ORS stabilized perioperative circulatory dynamics. Neither ORS nor mineral water consumption increased the stomach content volume.
Trial registration:
UMIN000019825 (Date of registration 17/11/2015)