bluuebunny/crossref_metadata_2025_split huggingface dataset:
Calidad educativa y modalidad de estudios en la educación superior
Authors: Ledesma Silva Yolanda Esperanza , Cobos Reina Ángel Rodrigo 
Published: January 2025

Introducción: Es un hecho que las instituciones de educación superior están preocupadas por mejorar la calidad educativa en sus diferentes modalidades ofertadas mediante la implementación de nuevas estrategias académicas y la optimización de recursos que permitan mejorar los contenidos de aprendizaje. Metodología: La investigación llevada a cabo fue de tipo descriptivo – correlacional, con enfoque cuantitativo, de corte transversal y diseño no experimental. La muestra poblacional incluyó a 280 estudiantes de dos Facultades de la Universidad Central del Ecuador, con una muestra de 280 alumnos; se utilizó un cuestionario con preguntas de escala Likert y preguntas de selección múltiple. Resultados: Se comprobó que existe una relación positiva moderada entre la modalidad de estudio y la calidad educativa y sus dimensiones; además, se realizó el proceso de regresión lineal mediante el análisis de la varianza (ANOVA) para la obtención de los coeficientes del modelo; también se hizo un análisis de las estrategias y recursos aplicados. Discusión: Los resultados de la presente investigación coincidieron con los obtenidos por varios autores. Conclusiones: El uso de estrategias, recursos adecuados y una capacitación en competencias digitales a docentes y estudiantes en las diferentes modalidades de estudio permite una mayor calidad educativa.
Pengaruh Disiplin Kerja dan Budaya Organisasi terhadap Kinerja Karyawan pada PT Kimia Farma Tbk Plant Jakarta
Authors: Dewi Novia Alvionita , Gandung Muhammad 
Published: January 2025

Penelitian ini bertujuan untuk mengetahui seberapa besarnya pengaruh antara disiplin kerja dan budaya organisasi terhadap kinerja karyawan pada PT Kimia Farma Tbk Plant Jakarta baik secara parsial maupun simultan. Metode yang digunakan dalam penelitian ini adalah metode kuantitatif dengan pendekatan Assosiatif Kausal. Jumlah populasi yang digunakan adalah 205 karyawan, lalu diambil sampel menggunakan rumus slovin dan diperoleh sampel berjumlah 67 responden. Hasil penelitian ini adalah Disiplin kerja secara parsial berpengaruh signifikan terhadap kinerja karyawan dengan regresi persamaan Y = 6.499 + 0,805 X1, lalu nilai t hitung (8,461 > 1,295) dan nilai sig 0,000 < 0,1 dengan demikian maka H01 ditolak Ha1 diterima, nilai korelasi sebesar 0,724 artinya memiliki tingkat hubungan yang kuat dan didapatkan nilai koefisien determinasi sebesar 52,4%. Budaya Organisasi secara parsial berpengaruh signifikan terhadap kinerja karyawan dengan regresi persamaan Y= 11.670 + 0,700 X2, lalu nilai t hitung (8,397 > 1,295) dan nilai sig 0,000 < 0,1. Dengan demikian maka H02 ditolak Ha2 diterima, nilai koefisien kolerasi sebesar 0,721 artinya memiliki tingkat hubungan yang kuat dan didapatkan nilai koefisien Determinasi 0,520. Disiplin Kerja dan Budaya Organisasi secara simultan berpengaruh signifikan terhadap kinerja karyawan dengan persamaan regresi Y= 6.534 + 0,445 X1+ 0,372 X2, lalu uji hipotesis F diperoleh nilai F hitung (41,830 > 2,39) dan nilai sig 0,000 < 0,1 maka dapat disimpulkan bahwa H03 ditolak dan Ha3 diterima, nilai korelasi sebesar 0,553 yang artinya memiliki tingkat hubungan sedang. Besarnya Adjusted R Square adalah sebesar 55,3 % dan sisanya 44,7% dipengaruhi oleh variabel lain yang tidak diteliti dalam penelitian ini.
Pengaruh Book Tax Differences dan Ukuran Perusahaan terhadap Persisten Laba di Perusahaan Sub-Sektor Farmasi yang Terdaftar di BEI Periode 2013-2023
Authors: Suherman Tiara Seftiani , Khuzaeni Khuzaeni 
Published: January 2025

Penelitian mengenai faktor-faktor yang memengaruhi persistensi laba menjadi menarik guna mengetahui apakah ada faktor pasti yang dapat memengaruhi persistensi laba. Penelitian ini mengambil dua faktor sebagai variabel bebas yaitu book tax differences dan ukuran perusahaan, book tax differences dapat memberikan keuntungan berupa beban pajak yang minimal, dan ukuran perusahaan merupakan gambaran tentang besar-kecilnya perusahaan berdasarkan (dalam penelitian ini) nilai total aset tahun berjalan. Penelitian ini bertujuan untuk mengetahui pengaruh book tax differences dan ukuran perusahaan terhadap persistensi laba dengan sampel berasal dari laporan keuangan perusahaan sub-sektor farmasi yang terdaftar di BEI periode 2013-2023. Metode analisis yang digunakan dalam penelitian ini adalah regresi panel data. Hasil analisis menunjukkan tidak adanya pengaruh secara signifikan book tax differences terhadap persistensi laba, namun ukuran perusahaan memberikan pengaruh signifikan terhdadap persistensi laba dan secara simultan book tax differences dan ukuran perusahaan berpengaruh signifikan terhadap persistensi laba di perusahaan sub-sektor farmasi periode 2013-2023. Dari hasil tersebut sangat penting bagi perusahaan untuk melakukan strategi perencanaan pajak dan menjaga pertumbuhan aktiva lancar dan aktiva tidak lancar.
Retensi Informasi Berbasis Aksesibilitas Buku Non-Teks Cerita Bergambar Dalam Meningkatkan Hasil Belajar Peserta Didik Sekolah Dasar
Authors: Sukniasih  , Sarwi  , Sudarmin  , Nur Cahyono Adi 
Published: January 2025

Penelitian ini bertujuan untuk mengetahui bagaimana Retensi Informasi siswa melalui pengembangan aksesibilitas buku non-teks sebagai media pembelajaran untuk meningkatkan pencapaian hasil tujuan pembelajaran pada siswa sekolah dasar kelas rendah yaitu kelas 1. Metode penelitian yang di gunakan menggunakan metode literature review atau tinjauan pustaka. Literature review merupakan kegiatan yang fokus terhadap sebuah topik spesifik yang menjadi minat untuk dianalisis secara kritis terhadap isi naskah yang dipelajari. Literature review ini menggunakan literatur terbitan tahun 2017-2024 yang dapat diakses fulltext dalam format pdf dan scholarly (peer reviewed journals) dengan menggunakan google schoolar dalam aplikasi Publish or Perish (PoP), penelitian ini mengeksplorasi bagaimana buku non-teks dapat diakses dan digunakan oleh siswa, serta dampaknya terhadap motivasi dan hasil belajar. Hasil penelitian menunjukkan bahwa penggunaan buku non-teks yang dirancang dengan baik dapat meningkatkan keterlibatan siswa dan hasil belajar.
Performance of Fluid Infusion Systems in the Changing Atmospheric Pressures Encountered in Aviation
Authors: Fan Ka Siu , Paterson Megan , Shojaee-Moradie Fariba , Manoli Antonios , Edwards Victoria , Lee Vivienne , Hutchison Ewan , Gifford Robert M. , Parsons Iain T. , Koehler Gerd , Mathieu Chantal , Mader Julia K. , King Bruce R. , Russell-Jones David , Consortium EASA 
Published: January 2025

INTRODUCTION: With the increasing use of aeromedical transport for critically ill patients, it is essential to understand the impact of pressure changes on drug infusion delivery systems. As airplanes ascend and descend, gases/bubbles are released from solutions when ambient pressure decreases and dissolves when pressure increases. This may affect mechanical fluid delivery systems and cause clinically significant changes, especially within a critical care setting. We aimed to evaluate the impact of pressure changes on volumetric pumps and syringe drivers.
METHODS: An in vitro study of six volumetric pumps and eight syringe drivers was conducted in a hypobaric chamber to mimic pressure changes during flights. Infusion devices were set to deliver water at 0.2 ml ⋅ h−1 and infused volumes were measured. There were 15 open-ended syringes also studied.
RESULTS: During ascent, syringe drivers and volumetric pumps over-delivered 173 µL and 38 µL of fluid. During descent, syringe drivers under-delivered by 166 µL, whereas volumetric pumps under-delivered by 9 µL. Syringe drivers experienced statistically significant changes in fluid delivery during both ascent and descent. In volumetric pumps, only the descent phase infusion differed significantly from other phases. The volume of fluid expansion is dependent on volume and the mechanical properties of the fluid.
DISCUSSION: Decreasing ambient pressure causes bubble formation, which displaces fluid, and increasing ambient pressure causes bubble reabsorption in mechanical infusion devices. Hence, atmospheric pressure changes during air travel may alter fluid delivery from medical fluid delivery systems and affect critically ill patients who require both aeromedical evacuation and accurate infusion of drugs.
Fan KS, Paterson M, Shojaee-Moradie F, Manoli A, Edwards V, Lee V, Hutchison E, Gifford RM, Parsons IT, Koehler G, Mathieu C, Mader JK, King BR, Russell-Jones D; EASA Consortium. Performance of fluid infusion systems in the changing atmospheric pressures encountered in aviation. Aerosp Med Hum Perform. 2025; 96(1):4–11.
Evidence-Based Aeromedical Assessments
Authors: Saehle Terje 
Published: January 2025

INTRODUCTION: Assessment of fitness for flight constitutes one of the core tasks of aeromedical professionals. The value of such evaluations depends on the decision to be based on complete medical information, valid risk methodology, and genuine flight safety indicators. To achieve these goals, the aeromedical practitioner should ensure an evidence-based approach.
METHODS: This article describes a pragmatic and evidence-based methodology for aeromedical fitness assessments, grounded on already validated principles within scientific epistemology and evidence-based clinical medicine.
RESULTS: The aeromedical assessment should integrate both individual variables of the particular applicant, deductive reasoning by relevant experts, and the best available scientific evidence. Each of these three pillars includes a set of specific aspects based on knowledge of precision medicine, flight environment, risk methodology, statistics, metacognition, and scientific method.
DISCUSSION: Despite evidence-based approach being the benchmark, the aeromedical practitioner should be aware of limitations and potential pitfalls. The conclusion should be based on both functional performance and future risk of medical incapacitation using a transparent and objective risk matrix.
Saehle T. Evidence-based aeromedical assessments. Aerosp Med Hum Perform. 2025; 96(1):71–77.
Analysis of respiratory pathogens in pediatric acute respiratory infections in Lanzhou, Northwest China, 2019-2024
Authors: Wang Qian , Pan Yunyan , Gao Hongwei , Zhao Youli , Gao Xinzhe , Da Yichen , Niu Shaomin , You Chongge 
Published: January 2025

ObjectiveThis study aimed to assess the prevalence and distribution of respiratory pathogens in children under 18 years old with Acute Respiratory Infections (ARTIs) in Lanzhou, Northwest China, from July 2019 to January 2024.MethodsThe respiratory pathogens studied were FluA, FluB, PIV, RSV, ADV, MP, CP, CB, and LP, detected by indirect immunofluorescence assay (IIF). Data were obtained from the laboratory information system (LIS) of the Lanzhou University Second Hospital. As in Lanzhou, NPIs were implemented in January 2020, and were lifted in December 2022, data were divided into pre-NPIs (July 2019 to December 2019), NPIs (January 2020 to December 2022) and post-NPIs (January 2023 to January 2024) periods for analysis. Pearson’s chi-square test, ANOVA, and Fisher’s exact test were used to evaluate statistical significance in variable differences, with P &lt; 0.05 considered significant.ResultsA total of 29,659 children diagnosed with ARTIs were included in the study, with 13030(43.93%) test positive for at least one pathogen. Single-pathogen infections predominated (33.10%), while co-detection of MP and PIV was the most common among multi-pathogen cases (52.96%). Pathogen detection rates were notably higher in female children (50.62%) and preschool-aged children (53.45%) and exhibited seasonal variations, with a pronounced increase in winter (47.61%) and a peak in November (48.92%). MP had the highest detection rate (38.59%), followed by PIV (10.18%). Detection rates significantly increased following the lifting of NPIs, rising from 33.82% (SD ± 13.13) during NPIs to 64.42% (SD ± 4.67) (P &lt; 0.001), with 2023 showing the highest detection rate (64.61%) and largest participant count (9,591). In November 2023, detection rates reached their highest level at 73.09%. Post-NPI, most pathogens, except CB and LP, demonstrated significantly higher prevalence (P&lt;0.001).ConclusionIn the Lanzhou region, MP and PIV were identified as the most prevalent respiratory pathogens among children with ARTIs, with peak detection rates during the winter season. Boys and school-age children exhibited higher susceptibility to these infections. NPIs played a critical role in reducing respiratory pathogen transmission. Once NPIs were lifted, a marked resurgence in pathogen incidence highlighted their impact on controlling infection spread.
Molecular insights into the interplay between type 2 diabetes mellitus and osteoporosis: implications for endocrine health
Authors: Jiang Liyun , Song Xia , Yan Li , Liu Yali , Qiao Xiumei , Zhang Wen 
Published: January 2025

BackgroundType 2 diabetes mellitus (T2DM) and osteoporosis are prevalent, interconnected chronic diseases that significantly impact global health. Understanding their complex biological relationship is crucial for improving patient outcomes and treatment strategies.MethodThis review examines recent research on the mechanisms linking T2DM with osteoporosis. It focuses on how abnormalities in bone metabolism, autophagy, ferroptosis, and vitamin D receptor (VDR) gene polymorphisms contribute to osteoporosis in T2DM patients.ResultsOur analysis indicates that T2DM is associated with reduced bone formation and increased bone resorption, which are influenced by hormonal changes, inflammation, and disrupted cellular signaling pathways. Additionally, increased perirenal fat thickness worsens osteoporosis through local inflammation and altered adipokine levels. VDR gene polymorphisms provide new molecular insights into this connection.ConclusionAddressing the identified mechanisms with targeted management strategies may improve bone health in individuals with T2DM. Future research should explore these associations in greater detail to develop more effective prevention and treatment strategies.
Identification of biomarkers for tumor regression grade in esophageal squamous cell carcinoma patients after neoadjuvant chemoradiotherapy
Authors: Chen Zhifu , Wang Yan , Chen Jun , Xu Zijun , Zhang Tingjuan , Sun Lu , Zhu Lihua , Xu Liben , Wu Chaoyang , Qiu Zhiyuan , Wang Dianjun , Wu Ting 
Published: January 2025

BackgroundEsophageal cancer is a highly invasive malignancy. Neoadjuvant chemoradiotherapy not only increases the rate of complete resection but also improves the median survival. However, a sensitive biomarker is urgently needed in clinical practice.Methods60 esophageal squamous cell carcinoma (ESCC) patients undergoing neoadjuvant chemoradiotherapy (NCRT) were enrolled at the People's Hospital Affiliated to Jiangsu University. Patients were grouped according to tumor regression grade (TRG) criteria from the College of American Pathologists (CAP). The correlation between TRG groups, clinicopathologic characteristics, and prognosis was analyzed. Differential gene expression analysis was performed on ESCC patients before and after NCRT using the public database (GSE43519). MMP9, NFIX, and GPR56 were identified as candidate genes, and their expression and correlation with prognosis were evaluated by immunohistochemical analysis.ResultsAmong 60 ESCC patients who underwent surgery after NCRT, the pathological complete response (pCR) rate was 35.0% (21/60), and the major pathological response (MPR) rate was 60.0% (36/60). Poor tumor differentiation and neural or vascular invasion were associated with inadequate tumor regression grade and were independent factors influencing TRG. ESCC patients were divided into effective (TRG 0 + 1) and ineffective (TRG 2 + 3) groups. Higher TRG was significantly associated with shorter overall survival (OS). Our study also identified TRG as an independent prognostic factor through univariate and multivariate Cox regression analyses (P &lt; 0.05). The differentially expressed genes GPR56, MMP9, and NFIX selected from the GSE43519 dataset were significantly downregulated after NCRT (P &lt; 0.001). Immunohistochemistry showed that GPR56 was highly expressed in ESCC, while it was negatively expressed in paracancerous tissues. There was a significant difference in expression between cancerous and paracancerous tissues. GPR56 expression was consistent with the public dataset, and patients with high GPR56 expression had significantly shorter OS (P &lt; 0.05). In addition, patients with inadequate MPR and high GPR56 expression had shorter OS (P &lt; 0.05).ConclusionsThe findings suggest that TRG serves as an independent prognostic factor for ESCC following NCRT. High GPR56 expression is found to be associated with a poor prognosis of ESCC. Downregulation of GPR56 suggests a potential significant predictive value in conjunction with MPR analysis.
The application of a clinical-multimodal ultrasound radiomics model for predicting cervical lymph node metastasis of thyroid papillary carcinoma
Authors: Liu Chang , Yang Shangjie , Xue Tian , Zhang Qian , Zhang Yanjing , Zhao Yufang , Yin Guolin , Yan Xiaohui , Liang Ping , Liu Liping 
Published: January 2025

BackgroundPTC (papillary thyroid cancer) is a lymphotropic malignancy associated with cervical lymph node metastasis (CLNM, including central and lateral LNM), which compromises the effect of treatment and prognosis of patients. Accurate preoperative identification will provide valuable reference information for the formulation of diagnostic and treatment strategies. The aim of this study was to develop and validate a clinical-multimodal ultrasound radiomics model for predicting CLNM of PTC.MethodsOne hundred sixty-four patients with PTC who underwent treatment at our hospital between March 2016 and December 2021 were included in this study. The patients were grouped into a training cohort (n=115) and a validation cohort (n=49). Radiomic features were extracted from the conventional ultrasound (US), contrast-enhanced ultrasound (CEUS) and strain elastography-ultrasound (SE-US) images of patients with PTC. Multivariate logistic regression analysis was used to identify the independent risk factors. FAE software was used for radiomic feature extraction and the construction of different prediction models. The diagnostic performance of each model was evaluated and compared in terms of the area under the curve (AUC), sensitivity, specificity, accuracy, negative predictive value (NPV) and positive predictive value (PPV). RStudio software was used to develop the decision curve and assess the clinical value of the prediction model.ResultsThe clinical-multimodal ultrasound radiomics model developed in this study can successfully detect CLNM in PTC patients. A total of 3720 radiomic features (930 features per modality) were extracted from the ROIs of the multimodal images, and 15 representative features were ultimately screened. The combined model showed the best prediction performance in both the training and validation cohorts, with AUCs of 0.957 (95% CI: 0.918–0.987) and 0.932 (95% CI: 0.822–0.984), respectively. Decision curve analysis revealed that the combined model was superior to the other models.ConclusionThe clinical-multimodal ultrasound radiomics model constructed with multimodal ultrasound radiomic features and clinical risk factors has favorable potential and high diagnostic value for predicting CLNM in PTC patients.
Pediatric reference values for total psoas muscle area in Korean children and adolescents
Authors: Kim Jisoo , Lee Mi-Jung , Lim Hyun Ji , Kwon Yonghan , Han Kyunghwa , Yoon Haesung 
Published: January 2025

BackgroundUniform cut-off values cannot be applied to children because muscle mass changes significantly with growth and different population groups have different races and lifestyles, so reference values from healthy children are needed.Materials and methodsPediatric patients (≤18 years of age) who underwent abdominal CT for abdominal pain in the emergency room without a past history from January 2015 to January 2021 were enrolled. Total psoas muscle area (tPMA) was calculated as bilateral psoas muscle areas drawn semi-automatically at the levels of L3–4 and L4–5. Graphs for weight and height were drawn and compared using data from the Korean national growth chart. tPMA distributions according to sex and age were obtained using quantile regression with smoothed polynomials. We analyzed correlations of tPMA with weight and height.ResultsA total of 740 pediatric patients were included [M:F = 340:400, 12 years (interquartile range 9–16)]. When compared to the Korean national growth chart, the 50th percentile values for height and weight in study population were not significantly different. At L3–4, the 50th percentile tPMA values ranged from 416 to 2,802 mm2 in males and 370 to 1,501 mm2 in females. The 50th percentile tPMA values for L4–5 ranged from 556 to 3,563 mm2 in males and from 579 to 2007 mm2 in females. In males, tPMA at L3–4 and L4–5 showed positive correlations with weight (r = 0.87; r = 0.87, P &lt; 0.001, both) and height (r = 0.82; r = 0.84, P &lt; 0.001, both). tPMA at L3–4 and L4–5 were positively correlated with weight (r = 0.77; r = 0.81, P &lt; 0.001, both) and height (r = 0.61; r = 0.67, P &lt; 0.001, both) in females.ConclusionWe provided sex-specific and age-specific growth charts and developed an online calculator for tPMA at the levels of L3–4 and L4–5, which can serve as an evaluation guide for muscle mass in Korean children.
Effects of blood flow restriction training on cardiometabolic health and body composition in adults with overweight and obesity: a meta-analysis
Authors: Kong Hao , Zhang Yilin , Yin Mingyue , Xu Kai , Sun QingGuo , Xie Yun , Girard Olivier 
Published: January 2025

ObjectiveThis meta-analysis aims to evaluate the effects of blood flow restriction (BFR) training on cardiometabolic health and body composition in adults with overweight and obesity.MethodFollowing PRISMA guidelines, a systematic search of PubMed (MEDLINE), EMBASE, Web of Science, Cochrane, and Scopus databases was conducted on 15 March 2024. Pooled effects for each outcome were summarized using Hedge’s g (g) through meta-analysis-based random effects models, and subgroup analyses were used to explore moderators.ResultsA total of 11 studies with 242 participants (Age:32.6 ± 3.6, BMI:27.2 ± 3.5) were included. Regarding cardiometabolic health, BFR training significantly reduced systolic blood pressure (g = 0.62 [0.08, 1.16], p = 0.02), while no significant differences were observed in maximal oxygen uptake (g = 0.48 [-0.21, 1.17], p = 0.17) or diastolic blood pressure (g = 0.31 [-0.22, 0.84], p = 0.25). Regarding body composition, BFR training significantly reduced body fat percentage (g = 0.30 [0.01, 0.58]; p = 0.04), while no significant differences (p &gt; 0.05) were observed in body weight (g = 0.14 [-0.14, 0.42]), body mass index (g = 0.08 [-0.21, 0.38]), waist circumference (g = 0.13 [-0.28, 0.53]), or waist-to-hip ratio (g = 0.48 [-0.19, 1.15]). Subgroup analysis revealed no significant difference in improving systolic blood pressure (g = 0.57 [-0.10, 1.24] vs. g = 0.70 [-0.18, 1.59]) and body fat percentage (g = 0.20 [-0.20, 0.61] vs. g = 0.45 [-0.05, 0.95]) between BFR resistance training and BFR aerobic training. In all selected studies, the overall risk of bias was categorized as “some concern”. The certainty of evidence for the BFR outcomes was low.ConclusionBFR training shows promise in improving cardiometabolic health and body composition, indicating that it may serve as a beneficial, individualized exercise prescription for improving cardiovascular disease risk and fat loss in adults with excess body weight and obesity.Systematic Review Registration:https://archive.org/details/osf-registrations-uv6jx-v1.