bluuebunny/crossref_metadata_2025_split huggingface dataset:
Numerical study of the circulation and its contribution to the oil slick transport in the southeastern part of the Black Sea
Authors: Demetrashvili Demuri , Kukhalashvili Vepkhia , Kvaratskhelia Diana 
Published: April 2023

Abstract

The relevance of studying and forecasting regional circulation and the spread of impurities in the shelf/coastal zones of the seas is determined by intensive human economic activity, which causes a large anthropogenic load on coastal marine ecosystems. The aim of this paper is to study the mesoscale circulation under real atmospheric forcing and its contribution to the oil slick transport in the southeastern part of the Black Sea using a regional model of the Black Sea dynamics (RM-IG) and a 2-D oil slick transport model, which is coupled to the RM-IG. The RM-IG with 1 km horizontal resolution is based on a z-level primitive equations system of ocean hydrothermodynamics. During the EC project ARENA (2003–2005) the RM-IG was nested in the basin-scale model of the Black Sea dynamics of Marine Hydrophysical Institute (Sevastopol, Ukraine) with 5 km horizontal resolution. The transport model is based on 2-D advection-diffusion equation for non-conservative substances. Atmospheric forcing is taken into account by prognostic meteorological fields derived from the atmospheric model SKIRON. Numerical experiments have shown that during all seasons there is a generation, deformation, and disappearance of anticyclonic and cyclonic meso- and submesoscale vortex formations, which have a significant impact on the pollutants dispersion process. Intensive vortex formations are observed during light winds. Strong winds have a smoothing effect and prevent the formation of vortex structures. In a number of cases, the unstable eddy formations with a diameter of 5–20 km are generated in a narrow strip along the Georgian coast presenting a width of about 20–30 km.
Dynamic damage and response characteristics of the tunnel by FEM modeling and field trials
Authors: Zheng Xianjun , Wu Tingyao , Wu Chao , Wang Xiaoqin 
Published: April 2023

The dynamic response characteristics of the tunnel and the stability of the surrounding rock are crucial to its safety of the tunnel. Combining the numerical simulation software and field measurement results, the change of peak particle vibration (PPV) and stress were analyzed, based on the longitudinal wave data from the acoustic tests, the blasting damage effects under the action of different blasting counts, including different locations in the deep part of the surrounding rock, were investigated. The results show that: (1) in the vertical direction of the tunnel, the PPV of the tunnel floor and tunnel sidewall is larger, the PPV of the tunnel top is the second, and the tunnel arch shoulder and arch foot is the smallest; (2) under the action of blasting, the stress concentration at the tunnel bottom and arch foot is easier, and the stress monitoring should be strengthened; (3) The depth of damage at different distances was 1.5 m and 3.0 m, respectively, and the depth of damage to the surrounding rock increased from 2.5 m to 4.0 m when the number of blasts was 10 and the number of blasts was 10.
Aldehyde Dehydrogenases as Promising Targets for Treating Toxic
Aldehyde-related Diseases
Authors: Chen Yu , Li Xin 
Published: April 2023

Background:
Mammals are exposed to various endogenous and exogenous aldehydes,
and aldehyde dehydrogenases (ALDHs) function to metabolize these aldehydes
into acids in order to counteract aldehyde over-load. ALDHs, therefore, play important
roles in a series of physiological and pathophysiological processes. ALDHs activators and
inhibitors are not only important probes for exploring ALDHs functions, but promising
for the treatment of toxic aldehyde-related diseases.

Methods:
This review has comprehensively summarized the categories and characteristics
of 19 human ALDHs, elaborated their related biological pathways, such as alcohol metabolism,
retinoic acid (RA) production, neurotransmitter metabolism, etc. In addition, reported
ALDHs activators and inhibitors have been summarized by listing their target, inhibition
form, and clinical application.

Results:
On the one hand, summarization of the types and relative functions is useful for
further research on aldehyde metabolic pathways and related diseases. On the other hand,
a review of existing activators and inhibitors of ALDHs contributes to discovering new
leading compounds and provides new insights.

Conclusion:
In consideration of the important role ALDH plays in toxic aldehyde-related
diseases, ALDHs are promising targets for the treatment of toxic aldehyde-related diseases,
and more research efforts are required to explore their pathophysiology and to develop
new regulators.
PBPK Modeling as an Alternative Method of Interspecies Extrapolation
that Reduces the Use of Animals: A Systematic Review
Authors: Lancheros Porras Karen Dayana , Alves Izabel Almeida , Novoa Diana Marcela Aragón 
Published: April 2023

Introduction:
Physiologically based pharmacokinetic (PBPK) modeling is a computational
approach that simulates the anatomical structure of the studied species and presents
the organs and tissues as compartments interconnected by arterial and venous blood flows.

Aim:
The aim of this systematic review was to analyze the published articles focused on
the development of PBPK models for interspecies extrapolation in the disposition of
drugs and health risk assessment, presenting to this modeling an alternative to reduce the
use of animals.

Methods:
For this purpose, a systematic search was performed in PubMed using the following
search terms: “PBPK” and “Interspecies extrapolation”. The revision was performed
according to PRISMA guidelines.

Results:
In the analysis of the articles, it was found that rats and mice are the most commonly
used animal models in the PBPK models; however, most of the physiological and
physicochemical information used in the reviewed studies were obtained from previous
publications. Additionally, most of the PBPK models were developed to extrapolate
pharmacokinetic parameters to humans and the main application of the models was for
toxicity testing.

Conclusion:
PBPK modeling is an alternative that allows the integration of in vitro and in
silico data as well as parameters reported in the literature to predict the pharmacokinetics
of chemical substances, reducing in large quantity the use of animals that are required in
traditional studies.
Molecular Mechanism of Tau Misfolding and Aggregation: Insights
from Molecular Dynamics Simulation
Authors: Zhong Haiyang , Liu Hongli , Liu Huanxiang 
Published: April 2023

Abstract:
Tau dysfunction has a close association with many neurodegenerative diseases,
which are collectively referred to as tauopathies. Neurofibrillary tangles (NFTs)
formed by misfolding and aggregation of tau are the main pathological process of tauopathy.
Therefore, uncovering the misfolding and aggregation mechanism of tau protein will
help to reveal the pathogenic mechanism of tauopathies. Molecular dynamics (MD) simulation
is well suited for studying the dynamic process of protein structure changes. It provides
detailed information on protein structure changes over time at the atomic resolution.
At the same time, MD simulation can also simulate various conditions conveniently.
Based on these advantages, MD simulations are widely used to study conformational
transition problems such as protein misfolding and aggregation. Here, we summarized
the structural features of tau, the factors affecting its misfolding and aggregation, and the
applications of MD simulations in the study of tau misfolding and aggregation.
The Structure-property Relationships of Clinically Approved
Protease Inhibitors
Authors: Choi Kihang 
Published: April 2023

Background:
Proteases play important roles in the regulation of many physiological
processes, and protease inhibitors have become one of the important drug classes.
Especially because the development of protease inhibitors often starts from a substrate-
based peptidomimetic strategy, many of the initial lead compounds suffer from pharmacokinetic
liabilities.

Objective:
To reduce drug attrition rates, drug metabolism and pharmacokinetics studies
are fully integrated into modern drug discovery research, and the structure-property relationship
illustrates how the modification of the chemical structure influences the pharmacokinetic
and toxicological properties of drug compounds. Understanding the structure-
property relationships of clinically approved protease inhibitor drugs and their analogues
could provide useful information on the lead-to-candidate optimization strategies.

Methods:
About 70 inhibitors against human or pathogenic viral proteases have been approved
until the end of 2021. In this review, 17 inhibitors are chosen for the structure-
property relationship analysis because detailed pharmacological and/or physicochemical
data have been disclosed in the medicinal chemistry literature for these inhibitors
and their close analogues.

Results:
The compiled data are analyzed primarily focusing on the pharmacokinetic or
toxicological deficiencies found in lead compounds and the structural modification strategies
used to generate candidate compounds.

Conclusion:
The structure-property relationships hereby summarized how the overall
druglike properties could be successfully improved by modifying the structure of protease
inhibitors. These specific examples are expected to serve as useful references and
guidance for developing new protease inhibitor drugs in the future.
Estrategia lúdica para estimular el aprendizaje en la asignatura de Biología Celular e Histología Médica
Authors: Muñoz Comonfort Armando , Rojas-Lemus Marcela , López-Valdez Nelly , Bizarro-Nevares Patricia , Fortoul Teresa Imelda 
Published: April 2023

Introducción: En la licenciatura de médico cirujano se incluyen asignaturas que tienen un alto índice de no acreditación, como es el caso de Biología Celular e Histología Médica (BCeHM), en especial por la identificación de imágenes. Una manera de ayudar al estudiantado a mejorar su desempeño académico es incluir actividades lúdicas.
Objetivo: Identificar el efecto de una estrategia lúdica en el desempeño académico en esta asignatura.
Método: 520 estudiantes de 3 generaciones de 6 grupos diferentes integraron la muestra de estudio. Tres grupos recibieron el material que llamamos “pirámide” y la manera de aplicarlo. Por cada estudiante del grupo experimental se buscó otro en los grupos control con las mismas condiciones iniciales de calificación del examen diagnóstico, bachillerato de procedencia y mismo sexo. El desempeño académico se determinó por las calificaciones promedio y los porcentajes de acreditación.
Resultados: Los estudiantes a los que se les aplicó la estrategia lúdica tuvieron en promedio calificaciones más altas en los exámenes departamentales y se apreció un porcentaje mayor de acreditación comparados con el grupo control, diferencias que fueron estadísticamente significativas.
Conclusión: La estrategia lúdica ayudó a que los estudiantes tuvieran un mayor desempeño académico y un mayor índice de aprobación en la asignatura de BCeHM.
Climate change impact on food security: A review
Authors: Rosalia Amelia Choya Tia , Mulyaningsih Tri 
Published: April 2023

Countries all over the globe are facing climate change. Global warming is a real problem that occurs and affects food production. Precipitation and temperature rise are causes of the changes observed in this study. This study examines the relationship between food security level due to climate change. To provide further clarity, a systematic literature review (SLR) towards the impacts of climate change was conducted to identify the extent of its impacts on food security and to identify the extent of its impacts on the level of food security and research gaps. This systematic review identifies and analyzes documents on the impact of climate change on the level of food security in terms of the impact of climate change, the methods used to analyze climate change, and the available climate change adaptation policies. Following SLR guidelines, Google Scholar is the main database. This research can broaden our knowledge about the impacts of climate change and the role we can play in maintaining food security.
The efficacy of chewing gum in the reduction of orthodontic pain at its peak intensity: a systematic review and meta-analysis
Authors: Mando Mahmoud , Talaat Sameh , Bourauel Christoph 
Published: April 2023

ABSTRACT

Objectives
To evaluate the efficacy of chewing gum on the intensity of pain in patients undergoing orthodontic treatment.

Materials and Methods
A search strategy that included both a manual search and a search of electronic databases was implemented; the electronic databases included PubMed, Cochrane Central Register of Controlled Trials (CENTRAL), ScienceDirect, Scopus, and EBSCO. Only randomized controlled trials were included in this study. All of the studies were assessed independently and in duplicate in accordance with the exclusion and inclusion criteria. The Cochrane risk of bias tool was used to evaluate the risk of bias within the included studies, and the GRADE approach was used to evaluate the certainty of evidence.

Results
Sixteen RCTs were included in the final analysis. The meta-analysis revealed that chewing gum significantly reduced pain intensity in comparison to pharmacologic agents (mean difference [MD] −0.50 [95% confidence interval {CI} −0.90 to −0.10], P = .01). When compared with a placebo, chewing gum significantly reduced pain intensity (MD −0.60 [95% CI −1.06 to −0.13], P = .01), while bite wafer and chewing gum groups had the same levels of reduction in pain intensity (MD −0.15 [95% CI −0.56 to 0.26], P = .48).

Conclusions
In patients undergoing fixed orthodontic treatment, chewing gum was significantly more effective than both pharmacologic agents and placebo in reducing orthodontic pain 24 hours after the initial placement of the archwire.
Gestational Diabetes Mellitus, Postpartum Lipidomic Signatures, and Subsequent Risk of Type 2 Diabetes: A Lipidome-Wide Association Study
Authors: Wang Guoying , Buckley Jessie P. , Bartell Tami R. , Hong Xiumei , Pearson Colleen , Wang Xiaobin 
Published: April 2023

OBJECTIVE
To identify a postpartum lipidomic signature associated with gestational diabetes mellitus (GDM) and investigate the role of the identified lipids in the progression to type 2 diabetes (T2D).

RESEARCH DESIGN AND METHODS
This prospective cohort study enrolled 1,409 women at 24–72 h after delivery of a singleton baby and followed them prospectively at the Boston Medical Center. The lipidome was profiled by liquid chromatography-tandem mass spectrometry. Diagnoses of GDM and incident T2D were extracted from medical records and verified using plasma glucose levels.

RESULTS
Mean (SD) age of study women at baseline was 28.5 (6.6) years. A total of 219 (16.4%) women developed incident diabetes over a median follow-up of 11.8 (interquartile range 8.2–14.8) years. We identified 33 postpartum lipid species associated with GDM, including 16 inverse associations (primarily cholesterol esters and phosphatidylcholine plasmalogens), and 17 positive associations (primarily diacyglycerols and triacyglycerols). Of these, four were associated with risk of incident T2D and mediated ∼12% of the progression from GDM to T2D. The identified lipid species modestly improved the predictive performance for incident T2D above classical risk factors when the entire follow-up period was considered.

CONCLUSIONS
GDM was associated with a wide range of lipid metabolic alterations at early postpartum, among which some lipid species were also associated with incident T2D and mediated the progression from GDM to T2D. The improvements attained by including lipid species in the prediction of T2D provides new insights regarding the early detection and prevention of progression to T2D.
Cost Analysis of Outpatient Care for Mental and Behavioral Disorders due to Psychoactive Substance Use: A Study of Four Community and Two General Hospitals in Thailand
Authors: Suanrueang Passakorn , Wongsin Utoomporn 
Published: April 2023

This cost analysis study gathered cost information from four community hospitals and two general hospitals in the fiscal year 2014, including service data, hospital statistics, and financial information. The study aimed to analysis and estimate the treatment costs of outpatient mental and behavioral disorders (MBDs) due to psychoactive substance use, provided at community and general hospitals in Thailand. We used ICD-10 codes, F10-F19, to handle the diagnosis codes of MBDs due to psychoactive substances and cost analysis. The unit cost per OPD visit was analyzed according to the cost analysis guidelines of the Ministry of Public Health, Thailand, using two procedures: a traditional method and a cost-to-charge ratio.
The great majority of service expenses were labour costs (53%), followed by material costs (42%) and capital costs (6%). The unit cost per OPD visit for substance use disorders (SUD) in 2014 ranged between 172 and 762 THB. It was adjusted by the inflation rate to estimate the cost for 2021. The costs were growth in the range of 204 to 905 THB. The median cost estimate in 2021 from four community hospitals and two general hospitals, each accounting for 396 and 769 THB, respectively.
The unit SUD visit costs of OPD from these six hospitals are quite close to the unit costs of the drug treatment centers. The greatest proportion of total service expenses was labor costs. Accordingly, human resources are believed to be a crucial challenge that needs to be considered and planned to deliver successful services.
Notably, these hospitals were selected by purposive sampling and might not be representative of each hospital type. More hospitals should, therefore, be recruited in further research to represent the actual cost by hospital type.
The Effectiveness of Scenario-Based Training of Clinicians in the Use of Electronic Health Records – A Systematic Literature Review
Authors: Olley Richard , Hozynka Jeremy 
Published: April 2023

The digitalisation of healthcare represents another change challenge for clinicians, and the most prominent of these is the Electronic Health Record (EHR). Adopting the EHR, including the training of clinicians of all disciplines, often does not occur effectively, which increases the risk of adverse events and the reduction in the quality and safety of clinical care. The competent use of the EHR requires clinician user training. One form of training is scenario-based. The questions asked of the literature in this SLR are what evidence exists as to the effectiveness of using scenarios to train clinicians in using the EHR, and is there a research gap in this evidence to inform future research?
To undertake this systematic review of the literature, the researchers implemented the PRISMA Method. Only highly ranked, health-related academic databases accessed through an electronic library catalogue were used to search for relevant peer-reviewed/refereed articles. The decision to apply the PRISMA method was based on the PRISMA statement, which safeguards comprehensive reporting and transparency to ensure inferred recommendations and interventions are based on the best available evidence.
6,898 records were returned from Boolean searches for articles published between November 2018 to November 2021. Five articles were included for greater analysis following exclusions by title review, abstract review, and quality assessment. Quality assessment of articles reporting empirical studies relating to the effectiveness of using scenarios in this type of training was performed using the standard quality assessment scoresheet by Kmet [48].
Three themes emerged from the literature. The centrality of workflow, Clinician engagement are key, and scenario-based training is one of many training strategies implemented.
The authors found that further rigorous research studies are required to enhance the evidence body for the continued usage of scenario-based training of clinicians to effectively use the EHR, particularly as the digital landscape within health continues to evolve. Moreover, the authors posit that further research on scenario-based EHR training of clinicians should include:

Scenario-based training is just one part of a broader and blended EHR training suite.
Ensuring future studies encompass a diversity of all fields of clinical roles within the research and,
Include standardised terminology naming for clinicians' scenario-based EHR training within the studies.
Barriers And Facilitators to Accessing Medical Services in Rural And Remote Australia: A systematic review
Authors: Thorn Harrison , Olley Richard 
Published: April 2023

Objective: This qualitative review aims to identify and list the barriers and facilitators to accessing medical services for rural and remote Australians, within the current literature to inform policy development and highlight the need for further research.
Methods: The review was guided by the PRISMA method. Boolean search strings identified relevant articles using the Griffith University Library electronic catalogue. The study included only English language research articles published between August 31st, 2018 and August 31st, 2021, focusing on facilitators and barriers within the Australian context considering both access and rurality/remoteness.
Results: Thematic analysis of six articles identified ten barriers: communication, confidentiality, fear and shame, funding, geography, health behaviours, reliance on others, service provision, staffing, transport; and eight facilitators: collaboration/partnerships, communication, cultural safety funding, service provision, staffing, and telehealth, to accessing medical services in rural and remote Australia.
Conclusion: Ten barriers and eight facilitators to accessing medical services in rural and remote Australia were identified and listed from six articles identified through a qualitative review. This review identified a research gap regarding understanding the underlying challenges behind these barriers and facilitators and the implications for policy implementation to improve access to medical services.
Resource-based View: A new strategic perspective for public health service managers
Authors: Kosiol Jennifer , Fraser Linda , Fitzgerald Anneke , Radford Katrina 
Published: April 2023

The resource-based view (RBV) theory is a widely accepted strategic management theory, particularly within private sector organisations. [1,2,3] However, within public healthcare settings, the level of empirical support available on the use and appropriateness of RBV within this environment is largely unchartered. Consequently, this paper aimed to further understand the level of evidence for the purpose of providing an insight into how it may be used to improve the efficiency and effectiveness of public health organisations.
An extensive literature search returned a total of 859 studies. Of these, just 13 studies met the inclusion criteria of being an investigation of the use of RBV theory in public sector healthcare organisations. The analysis conducted demonstrates that while the use of RBV theory has been relatively slow, the benefits are positive.
The practical application of RBV theory lies in strategically mapping the relationships between resources, capabilities, and public value, relevant to healthcare organisations, in order to gain and understand how public value is created to provide a competitive advantage and superior performance for the organisation.