bluuebunny/crossref_metadata_2025_split huggingface dataset:
Glycolysis and de novo fatty acid synthesis cooperatively regulate pathological vascular smooth muscle cell phenotypic switching and neointimal hyperplasia
Authors: Cao Kaixiang , Zhang Tiejun , Li Zou , Song Mingchuan , Li Anqi , Yan Jingwei , Guo Shuai , Wang Litao , Huang Shuqi , Li Ziling , Hou Wenzhong , Dai Xiaoyan , Wang Yong , Feng Du , He Jun , Fu Xiaodong , Xu Yiming 
Published: January 2023

AbstractSwitching of vascular smooth muscle cells (VSMCs) from a contractile phenotype to a dedifferentiated (proliferative) phenotype contributes to neointima formation, which has been demonstrated to possess a tumor‐like nature. Dysregulated glucose and lipid metabolism is recognized as a hallmark of tumors but has not thoroughly been elucidated in neointima formation. Here, we investigated the cooperative role of glycolysis and fatty acid synthesis in vascular injury‐induced VSMC dedifferentiation and neointima formation. We found that the expression of hypoxia‐inducible factor‐1α (HIF‐1α) and its target 6‐phosphofructo‐2‐kinase/fructose‐2,6‐bisphosphatase (PFKFB3), a critical glycolytic enzyme, were induced in the neointimal VSMCs of human stenotic carotid arteries and wire‐injured mouse carotid arteries. HIF‐1α overexpression led to elevated glycolysis and resulted in a decreased contractile phenotype while promoting VSMC proliferation and activation of the mechanistic target of rapamycin complex 1 (mTORC1). Conversely, silencing Pfkfb3 had the opposite effects. Mechanistic studies demonstrated that glycolysis generates acetyl coenzyme A to fuel de novo fatty acid synthesis and mTORC1 activation. Whole‐transcriptome sequencing analysis confirmed the increased expression of PFKFB3 and fatty acid synthetase (FASN) in dedifferentiated VSMCs. More importantly, FASN upregulation was observed in neointimal VSMCs of human stenotic carotid arteries. Finally, interfering with PFKFB3 or FASN suppressed vascular injury‐induced mTORC1 activation, VSMC dedifferentiation, and neointima formation. Together, this study demonstrated that PFKFB3‐mediated glycolytic reprogramming and FASN‐mediated lipid metabolic reprogramming are distinctive features of VSMC phenotypic switching and could be potential therapeutic targets for treating vascular diseases with neointima formation. © 2023 The Pathological Society of Great Britain and Ireland.
In‐silico identification of Tyr232 in AMPKα2 as a dephosphorylation site for the protein tyrosine phosphatase PTP‐PEST
Authors: Manikandan Amrutha , T.S. Sreevidya , Manoj Narayanan , Vemparala Satyavani , Dixit Madhulika 
Published: January 2023

AbstractThe AMP‐activated protein kinase (AMPK) is known to be activated by the protein tyrosine phosphatase non‐receptor type 12 (PTP‐PEST) under hypoxic conditions. This activation is mediated by tyrosine dephosphorylation of the AMPKα subunit. However, the identity of the phosphotyrosine residues that PTP‐PEST dephosphorylates remains unknown. In this study, we first predicted the structure of the complex of the AMPKα2 subunit and PTP‐PEST catalytic domain using bioinformatics tools and further confirmed the stability of the complex using molecular dynamics simulations. Evaluation of the protein–protein interfaces indicated that residue Tyr232 is the most likely dephosphorylation site on AMPKα2. In addition, we explored the effect of phosphorylation of PTP‐PEST residue Tyr64 on the stability of the complex. Phosphorylation of the highly conserved Tyr64, an interface residue, enhances the stability of the complex via the rearrangement of a network of electrostatic interactions in conjunction with conformational changes in the catalytic WPD loop. We generated a phosphomimetic (PTP‐PEST‐Y64D) mutant and used co‐immunoprecipitation to study the effect of PTP‐PEST phosphorylation on AMPKα2 binding. The mutant exhibited an increased affinity for AMPKα2 and corroborated the in‐silico predictions. Together, our findings present a plausible structural basis of AMPK regulation by PTP‐PEST and show how phosphorylation of PTP‐PEST affects its interaction with AMPKα2.
Effect of Nigella sativa L. seed oil on urinary incontinence and quality of life in menopausal women: A triple‐blind randomized controlled trial
Authors: Alizadeh Afsaneh , Mohammah‐Alizadeh‐Charandabi Sakineh , Khodaie Laleh , Mirghafourvand Mojgan 
Published: January 2023

AbstractIncreased urinary incontinence is one of the most common changes during menopause. This study aimed to investigate the effect of Nigella sativa L. seed oil on urinary incontinence and quality of life (QoL) (primary outcomes) and sexual function (secondary outcome) in menopausal women. In this triple‐blind randomized controlled trial, 60 women in Tabriz‐Iran were equally allocated into two treatment and control groups using block randomization. The women applied 2–3 drops of Nigella sativa L. seed oil or placebo on their stomachs below the novel twice a day for 8 weeks. The data collection instruments were completed at baseline and just after the intervention. After intervention, the mean rank score of mixed urinary incontinence was significantly lower (p = .04) and the mean score of the incontinence‐QoL was significantly higher (mean difference 12.63, 95% CI 2.33 to 22.93; p = .017) in the treatment group than the control group. However, there were no significant differences in stress incontinence, urge incontinence, sexual function, and menopause‐specific QoL of women between the groups (p > .05). The results indicated the positive effect of the Nigella sativa L. seed oil on mixed incontinence and incontinence‐QoL; nevertheless, to make a certain conclusion, further studies are required.
Design, Synthesis of Dioxopiperidinamide Derivatives by Amide Coupling Reaction and Study of Their Biological Activity
Authors: Kaliraj S. , Radhakrishnan Jeyalakshmi 
Published: January 2023

AbstractA series of fifteen dioxopiperidinamide derivatives synthesized and their spectra chemical data were reported. An alternative amide coupling reaction has been followed by using 3‐aminopiperidine‐2,6‐dione through amide bond functionalization between N‐Ethyl‐N′‐(3‐dimethylaminopropyl)carbodiimide hydrochloride (EDC.HCl) and Hydroxybenzotriazole (HOBt). All the designed compounds were docked in to the active sites of 2 A73: Human Complement Component C3. All the docked compounds is favorable to make both hydrogen and hydrophobic interaction with amino acids located at the binding site. The most of potential compounds (E)‐N‐(2,6‐dioxopiperidin‐3‐yl)‐3‐(m‐tolyl)acrylamide (4 g), (E)‐3‐(4‐bromophenyl)‐N‐(2,6‐dioxopiperidin‐3‐yl)acrylamide (4 h) and N‐(2,6‐dioxopiperidin‐3‐yl)‐3‐methyl‐4‐oxo‐4,6,7,8,9,10‐hexahydrothieno [2′,3′:4,5]pyrimido[1,2‐a]azepine‐2‐carboxamide (7) studied for their anticancer activity on the THP‐1 cancer cells line. It was also further established their Anti‐inflammatory activity and Antioxidant activity with the comparable efficiency against those of clinically used drugs.
Highly Selective Aminopyrazine‐Based Colorimetric Probe for “Naked‐Eye” Detection of Al3+: Experimental, Computational Studies and Applications in Molecular Logic Circuits
Authors: Sharma Shivani , Chayawan  , Jayaraman Adithyan , Debnath Joy , Ghosh Kalyan Sundar 
Published: January 2023

AbstractA simple colorimetric probe NPA was synthesized using 2‐aminopyrazine and 2‐hydroxynaphthaldehyde. The probe had demonstrated quick response and high selectivity toward Al3+ in the presence of other interfering metal ions. A notable color change from bright yellow to colorless was noticed on addition of aqueou solutions of Al3+ to NPA in CH3CN‐H2O (1 : 1, v/v) in physiological pH range. 1 : 1 stoichiometry in NPA‐Al3+ complex was confirmed from Job's plot and mass spectrometry. Complexation of Al3+ with the probe molecule was also confirmed using 1H NMR spectroscopy. A theoretical model structure of the complex was proposed based on density functional theory (DFT). Disruption of conjugation in the naphthalene moiety and enhancement in intramolecular charge transfer (ICT) in the complex had decreased the absorbance of NPA. Paper strip of NPA was used for fast “on‐site” detection of Al3+ without using any spectroscopic instrument. The probe was found reusable for several times. The probe can also be used for the development of molecular logic gate for the detection of Al3+.
A BaCO3 Nanomaterial for Pyrolysis of Sustainable Waste and Virgin Polystyrene into Green Aromatic Derivatives
Authors: Singh Man Vir 
Published: January 2023

AbstractGreen aromatic derivatives (GADs) were obtained from waste polystyrene thermocol (WPST) and virgin polystyrene (VPS) through pyrolysis using BaCO3 (Barium carbonate nanomaterial). BaCO3 nanomaterial was synthesized in the laboratory, and their properties were characterized through XRD, EDX, and SEM. WPST and VPS were analyzed through TGA for thermal stability, and FT‐IR determined the functional groups. GADs obtained from WPST and VPS were analyzed through GC‐MS‐MS and FT‐IR. GADs were analyzed through GC‐MS‐MS and found their results were aromatic derivatives (99.29 % from VPS, while 88.77 % from WPST) and aliphatic (0.29 % from VPS, while 11.23 % from WPST). In the first experiment, 95 g VPS plastics and 5 g BaCO3 were used; the recovered quantities of liquid GADs, py‐gases, and residues amount to 90 %, 9.9 %, and 0.12 %. In the second experiment, 93 % liquid GADs, 6.85 % py‐gases (pyrolysis gases), and 0.15 % residue from 70 g VPS+20 g WTPS and 10 g BaCO3 were obtained. In the third experiment, 85 % GADs, 14.82 % py‐gases, and 0.18 % residue from 100 g WTPS without catalyst were collected. GADs were successfully obtained without any problem. GADs can be used as raw materials in chemical industries and refineries.
Bandgap Tunable Oxynitride LaNb2O7–xNx Nanosheets
Authors: Hsu Chu‐Wei , Miyano Takuro , Awaya Keisuke , Tsushida Masayuki , Hatakeyama Kazuto , Koinuma Michio , Ida Shintaro 
Published: January 2023

AbstractBandgap tunable lanthanum niobium oxynitride [LaNb2O7‐xNx](1+x)− nanosheet is prepared by the delamination of a Ruddlesden−Popper phase perovskite oxynitride via ion−exchange and two−step intercalation processes. The lanthanum niobium oxynitride nanosheets have a homogeneous thickness of 1.6 nm and exhibit a variety of chromatic colors depending on the nitridation temperature of the parent‐layered oxynitride. The bandgap energy of the nanosheets is determined by ultraviolet photoemission spectroscopy, Mott–Schottky, and photoelectrochemical measurements and is found to be tunable in the range of 2.03–2.63 eV. Furthermore, the oxide/oxynitride superlattice structures are fabricated by face−to−face stacking of 2D crystals using oxynitride [LaNb2O7‐xNx](1+x)− and oxide [Ca2Nb3O10]− nanosheets as building blocks. Moreover, the superlattices‐like restacked oxynitride/oxide nanosheets hybrid exhibits unique proton conductivity and dielectric properties strongly influenced by the oxynitride nanosheets and enhanced photocatalytic activity under visible light irradiation.
Role of MoOx Surficial Modification in Enhancing the OER Performance of Ru–Pyrochlore
Authors: Liu Tongtong , Guo Hengyu , Chen Yanan , Zhang Zhengping , Wang Feng 
Published: January 2023

AbstractPyrochlore ruthenate (Y2Ru2O7–δ) is highlighted as a promising oxygen evolution reaction (OER) catalyst for water splitting in polymer electrolyte membrane electrolyzers. However, an efficient electronic modulation strategy for Y2Ru2O7–δ is required to overcome its electrochemical inertness. Herein, a surface manipulation strategy involving implanting MoOx moieties on nano Y2Ru2O7–δ (Mo–YRO) using wet chemical peroxone method is demonstrated. In contrast to electronic structure regulation by intramolecular charge transfer (i.e., substitutional strategies), the heterogeneous Mo−O−Ru micro‐interfaces facilitate efficient intermolecular electron transfer from [RuO6] to MoOx. This eliminates the bandgap by inducing Ru 4d delocalization and band alignment rearrangement. The MoOx modifiers also alleviate distortion of [RuO6] by shortening Ru−O bond and enlarging Ru−O−Ru bond angle. This electronic and geometric structure tailoring enhances the OER performance, showing a small overpotential of 240 mV at 10 mA cm−2. Moreover, the electron‐accepting MoOx moieties provide more electronegative surfaces, which serve as a protective “fence” to inhibit the dissolution of metal ions, thereby stabilizing the electrochemical activity. This study offers fresh insights into the design of new‐based pyrochlore electrocatalysts, and also highlights the versatility of surface engineering as a way of optimizing electronic structure and catalytic performance of other related materials.
Multi‐Scale Design of Ultra‐Broadband Microwave Metamaterial Absorber Based on Hollow Carbon/MXene/Mo2C Microtube
Authors: Wang Jianqiao , Wu Ze , Xing Youqiang , Li Bingjue , Huang Peng , Liu Lei 
Published: January 2023

AbstractDeveloping various nanocomposite microwave absorbers is a crucial means to address the issue of electromagnetic pollution, but remains a challenge in satisfying broadband absorption at low thickness with dielectric loss materials. Herein, an ultra‐broadband microwave metamaterial absorber (MMA) based on hollow carbon/MXene/Mo2C (HCMM) is fabricated by a multi‐scale design strategy. The microscopic 1D hierarchical microtube structure of HCMM contributes to break through the limit of thickness, exhibiting a strong reflection loss of ‐66.30 dB (99.99997 wave absorption) at the thinnest matching thickness of 1.0 mm. Meanwhile, the strongest reflection loss of ‐87.28 dB is reached at 1.4 mm, superior to most MXene‐based and Mo2C‐based microwave absorbers. Then, the macroscopic 3D structural metasurface based on the HCMM is simulated, optimized, and finally manufactured. The as‐prepared flexible HCMM‐based MMA realizes an ultra‐broadband effective absorption in the range of 3.7‐40.0 GHz at a thickness of 5.0 mm, revealing its potential for practical application in the electromagnetic compatibility field.
FLUIDOT: A Modular Microfluidic Platform for Single‐Cell Study and Retrieval, with Applications in Drug Tolerance Screening and Antibody Mining
Authors: Breukers Jolien , Ven Karen , Struyfs Caroline , Ampofo Louanne , Rutten Iene , Imbrechts Maya , Pollet Francesca , Van Lent Julie , Kerstens Winnie , Noppen Sam , Schols Dominique , De Munter Paul , Thibaut Hendrik Jan , Vanhoorelbeke Karen , Spasic Dragana , Declerck Paul , Cammue Bruno P. A. , Geukens Nick , Thevissen Karin , Lammertyn Jeroen 
Published: January 2023

AbstractAdvancements in lab‐on‐a‐chip technologies have revolutionized the single‐cell analysis field. However, an accessible platform for in‐depth screening and specific retrieval of single cells, which moreover enables studying diverse cell types and performing various downstream analyses, is still lacking. As a solution, FLUIDOT is introduced, a versatile microfluidic platform incorporating customizable microwells, optical tweezers and an interchangeable cell‐retrieval system. Thanks to its smart microfluidic design, FLUIDOT is straightforward to fabricate and operate, rendering the technology widely accessible. The performance of FLUIDOT is validated and its versatility is subsequently demonstrated in two applications. First, drug tolerance in yeast cells is studied, resulting in the discovery of two treatment‐tolerant populations. Second, B cells from convalescent COVID‐19 patients are screened, leading to the discovery of highly affine, in vitro neutralizing monoclonal antibodies against SARS‐CoV‐2. Owing to its performance, flexibility, and accessibility, it is foreseen that FLUIDOT will enable phenotypic and genotypic analysis of diverse cell samples and thus elucidate unexplored biological questions.
The Current Status and Trends of Chinese Medicine Polysaccharides: A Bibliometric Review [1998–2021]
Authors: Feng Tao , Ma Zicheng , Li Jingya , Sun Lili , Wang Meng , Chen Meiling , Ren Xiaoliang 
Published: January 2023

AbstractChinese medicine polysaccharides refer to a class of active polysaccharides extracted from traditional Chinese medicines. They are widely used natural macromolecules with various pharmacological activities such as antiviral, antibacterial, anti‐inflammatory, anti‐cancer, anti‐hypertensive, and antioxidant effects, as well as affecting the immunomodulation and regulation of intestinal flora. In recent years, the research on Chinese medicine polysaccharides in pharmacological disciplines has grown rapidly. To understand the research trends of Chinese medicine polysaccharides, this study adopts a bibliometric approach based on the Web of Science core database (WoSCC) by analyzing the publication year, authors, countries/regions, organizations, journals, and critical characteristics of relevant literature to explore the current and future research trends related to Chinese medicine polysaccharides. In addition, the traditional and modern extraction methods of Chinese medicine polysaccharides are reviewed. This paper lays a framework for the development of Chinese medicine polysaccharides. The information helps researchers explore new directions and perspectives for future research.
The creation and diffusion of international business research
Authors: Buckley Peter J. 
Published: January 2023

Abstract“W(h)ither U.S. Hegemony in International Business Research?” by Grigorios Livanis and Michael Geringer, is an excellent effort to encompass the growth of international business (IB) scholarly research worldwide. This commentary examines the implicit assumptions and models of their analysis, showing that IB models are useful in explaining the scholarly growth of IB.
Mobile Eye-Tracking as a Research Method to Explore the D/Deaf Experience at Arts and Cultural Venues
Authors: Cumper Vanessa , Scarles Caroline , Liu Hongbo , Kimbu Albert 
Published: January 2023

AbstractD/deaf activists have consistently lamented their exclusion from the decision-making process by service providers. Accessibility is only effective when designed with contributions from those affected by the perceived or known barrier. This paper redresses the historic absence of the D/deaf paradigm, and recenters the focus to the individual’s perspective of accessibility requirements by developing a conceptual framework, constructed through the review of empirical and theoretical literature. The conceptual dimensions presented are from the D/deaf person’s perspective as valued through shared power and ownership. The aim of this conceptual paper is to explore how D/deaf-centric research can be applied and qualitatively measured through the combination of self-report, observation and Mobile eye tracking (MET).
Metaverse and Tourism: From a New Niche to a Transformation
Authors: Volchek Katerina , Brysch Armin 
Published: January 2023

AbstractMetaverse is named among the technologies that are predicted to transform everyday life. The proliferation of such technologies as the Internet and smartphones has triggered major transformations in the tourism industry. This paper conceptualises the phenomenon of Metaverse towards the phenomenon of tourism. It applies a semi-systematic literature review methodology to identify existing alignment between the phenomena. The paper concludes that there is a conceptual alignment between the critical dimensions of the Metaverse and tourism. Tourism should be ready for the reciprocal effects of metaverse development on tourism and vice versa, from new opportunities to enhance tourist experience to a possible dissolution of the contemporary understanding of tourism.
The investigations of the P-wave Bs states combining quark model and lattice QCD in the coupled channel framework
Authors: Yang Zhi , Wang Guang-Juan , Wu Jia-Jun , Oka Makoto , Zhu Shi-Lin 
Published: January 2023

Abstract
Combining the quark model, the quark-pair-creation mechanism and B(*)$$ \overline{K} $$

K
¯

interaction, we have investigated the near-threshold P-wave Bs states in the framework of the Hamiltonian effective field theory. With the heavy quark flavor symmetry, all the parameters are determined in the Ds sector by fitting the lattice data. The masses of the bottom-strange partners of the $$ {D}_{s0}^{\ast }(2317) $$

D

s
0

∗

2317

and $$ {D}_{s1}^{\ast }(2460) $$

D

s
1

∗

2460

are predicted to be $$ {M}_{B_{s0}^{\ast }}={5730.2}_{-1.5}^{+2.4} $$

M

B

s
0

∗

=

5730.2

−
1.5

+
2.4

MeV and $$ {M}_{B_{s1}^{\ast }}={5769.6}_{-1.6}^{+2.4} $$

M

B

s
1

∗

=

5769.6

−
1.6

+
2.4

MeV, respectively, which are well consistent with the lattice QCD component. The two P-wave Bs states are the mixtures of the bare $$ \overline{b}s $$

b
¯

s
core and B(*)$$ \overline{K} $$

K
¯

component. Moreover, we find a crossing point between the energy levels with and without the interaction Hamiltonian in the finite volume spectrum in the 0+ case, which corresponds to a CDD (Castillejo-Dalitz-Dyson) zero in the T-matrix of the $$ B\overline{K} $$
B

K
¯

scattering. This CDD zero will help deepen the insights of the near-threshold states and can be examined by future lattice calculation.
Effective field theory for leptoquarks
Authors: Meçaj Bianka , Neubert Matthias 
Published: January 2023

Abstract
Leptoquarks enter in several extensions of the Standard Model as possible solutions to a number of observed anomalies. We work within the soft-collinear effective theory framework to present a detailed analysis of the decay rates of the three leptoquarks that appear the most in literature, the scalars S1 and S3 and the vector $$ {U}_1^{\mu } $$

U
1
μ

. Using renormalization-group methods we resum the large logarithms arising from the evolution of the Wilson coefficients between the New Physics scale and the electroweak scale. We also derive the tree-level matching relations for the Wilson coefficients in the effective theory for some specific leptoquark models.
Simulation-based anomaly detection for multileptons at the LHC
Authors: Krzyzanska Katarzyna , Nachman Benjamin 
Published: January 2023

Abstract
Decays of Higgs boson-like particles into multileptons is a well-motivated process for investigating physics beyond the Standard Model (SM). A unique feature of this final state is the precision with which the SM is known. As a result, simulations are used directly to estimate the background. Current searches consider specific models and typically focus on those with a single free parameter to simplify the analysis and interpretation. In this paper, we explore recent proposals for signal model agnostic searches using machine learning in the multilepton final state. These tools can be used to simultaneously search for many models, some of which have no dedicated search at the Large Hadron Collider. We find that the machine learning methods offer broad coverage across parameter space beyond where current searches are sensitive, with a necessary loss of performance compared to dedicated searches by only about one order of magnitude.
Chaotic string motion in a near pp-wave limit
Authors: Kushiro Shodai , Yoshida Kentaroh 
Published: January 2023

Abstract
We revisit classical string motion in a near pp-wave limit of AdS5 × S5. It is known that the Toda lattice models are integrable. But if the exponential potential is truncated at finite order, then the system may become non-integrable. In particular, when the exponential potential in a three-particle periodic Toda chain is truncated at the third order of the dynamical variables, the resulting system becomes a well-known non-integrable system, Henon-Heiles model. The same thing may happen in a near pp-wave limit of AdS5 × S5, on which the classical string motion becomes chaotic.