bluuebunny/crossref_metadata_2025_split huggingface dataset:
First documentation of population dynamics and reproductive biology of big-scale sand smelt, A. boyeri Risso, 1810 in the coastal waters of the Southeast Caspian Sea- Northern Iran
Authors: Hajiradkouchak Eisa , Rahnama Behzad , Fazli Hasan 
Published: February 2025

IntroductionTo effectively manage fish stocks, evaluating various aspects of population dynamics is considered crucial. Understanding invasive species is essential for conservation efforts. This study represents the first documentation of population parameters.MethodsFor this purpose, the population dynamics parameters, including growth, mortality, and recruitment of A. boyeri, found in the Coastal Waters of the southeast Caspian Sea of Northern Iran, were analyzed using FiSAT II software. ResultThe analyzed specimens were sampled with a total weight range of 1.2 to 12.51 g and a total length range of 60 to 125 mm. The population has a 5-year life cycle. The length-weight relationship was estimated as W=0.0055 L3.0774 for males and W= 0.0083 L2.9185 for females. The slope value (b) of the length-weight relationships obtained for A. boyeri were between 2.69-3.13 with an average value of 2.91. While populations of A. boyeri showed negative allometric growth patterns, the males of exhibited positive allometric growth patterns, whereas the females had negative allometric growth patterns. The von Bertalanffy growth function fitted to back-calculated size at age data was: Lt = 126.5 [1- exp - 0.34(t + 0.234)] and Lt =131.3[1-exp- 0.35(t + 0.374)] for males and females respectively. The average relative condition factor was reported to be 0.62 and 0.79 for males and females respectively. The growth performance index (∅’) was reported to be 1.74 and 2.10 for males and females respectively. The total mortality of 1.73 year–1, consisting of natural mortality of 1.38 year–1 and fishing mortality of 0.35 year–1 and 1.21 year–1, consisting of natural mortality of 0.90 year–1 and fishing mortality of 0.31 year–1 was reported for males and females respectively. An exploitation rate of 0.20 and 0.26 for males and females respectively, is suggestive of a less exploited state of the fish. For both sexes, the length at first maturity was found to be higher than the length at first capture, a condition that can disturb the stock, as such the utility of a net with a relatively larger mesh size is advisable. The sex ratio was 1:1.34 in favor of females. For both sexes, the reproductive season, evaluated from GSI, extended from March to June, with a peak in April. The average absolute and relative fecundities were 2865 eggs and 684 eggs g-1 of body weight respectively. The diameter of oocytes ranged from 0.028 to 0.25 mm with a mean value of 0.54. DiscussionThe life-history patterns of A. boyeri in the population under study imply that the population of this species in the southeast Caspian Sea differs markedly from those of other localities of its range distribution. The differences were thought to be due to differences in geographical locations. The current research on the population dynamics of A. boyeri can be used as the baseline data for its management stocks.
Visual acuities as measured with an automatic intelligent visual acuity chart projector and standard logarithmic visual acuity chart: a prospective comparative study
Authors: Luo Mingyue , Liu Xinyu , Zhang Dingding , Chen Youxin , Kang Weijuan 
Published: February 2025

PurposeThis study aimed to test the repeatability of visual acuity (VA) measurement using an novel intelligent projector visual acuity (IP) chart (LSJ-IVAC-6000A, Hunan Liangshi Jia Biotechnology Co., Ltd.) and the consistency of VA measurement between the IP chart and the 5 m standard logarithmic visual acuity (SL) chart (GB11533-2011).MethodsIn this prospective comparative study, 53 subjects were included to test the internal repeatability of the IP chart. Both eyes of the subjects were tested three times, with a minimum interval of 10 min. The intraclass correlation coefficient (ICC) was used to evaluate the repeatability. One hundred subjects were included to test the consistency between two charts. Both eyes of the subjects were tested with two charts in random order with an interval of 10 min for each test. ICC and the Bland–Altman statistical analyses were used to analyze the consistency of the two charts. VA values were expressed by the logMAR recording method. The time consumption for each test was recorded in seconds.ResultsIn the repeatability analysis, the ICC values of the right and left eye were 0.968 (95% CI, 0.950–0.981, p &lt; 0.001) and 0.964 (95% CI, 0.944–0.978, p &lt; 0.001), respectively. In the consistency analysis, the ICC values of the right and left eye were 0.946 (95% CI, 0.919–0.963, p &lt; 0.001) and 0.817 (95% CI, 0.727–0.877, p &lt; 0.001), respectively. However, the 95% limits of agreement (LoA) of the differences in the VA measurements between the IP and SL chart for the right and left eye were −0.26 to 0.31 and −0.34 to 0.39, respectively, suggesting a certain degree of instability in the measurements of the SL chart. There was no significant difference in the time consumption of VA measurements between the two charts (p = 0.668). In the consistency analysis of subgroups by age, the ICC values were &gt;0.8 (p &lt; 0.001) in the most groups except for the left eyes of 51–70 years old subgroup which had an ICC value of 0.448 (95% CI, −0.919 to 0.841, p = 0.17), with 95% LoA of −1.02 to 0.77.ConclusionThe IP chart demonstrated good repeatability and overall consistency with the SL chart.
Changes in the blood cyclosporine level after switching from voriconazole to isavuconazole in a patient with aplastic anemia: insights from physiologically based pharmacokinetic model simulation and the Adverse Event Reporting System database study
Authors: Shiraishi Chihiro , Kato Hideo , Ino Kazuko , Iwamoto Takuya 
Published: February 2025

IntroductionIsavuconazole, a broad-spectrum triazole approved by the United States Food and Drug Administration (FDA) in 2015, moderately inhibits cytochrome P450 3A4. Although antifungal agents are often used concomitantly with cyclosporine, the effect of switching from voriconazole to isavuconazole on the blood cyclosporine level remains unclear.CaseA 63-year-old Japanese male was administered oral cyclosporine (10:00 and 21:00) for severe aplastic anemia. Following pneumonia with positive Aspergillus antigen and an elevated β-D-glucan level, antifungal therapy was initiated. After switching from voriconazole (10:00 and 21:00) to isavuconazole (approximately 08:00), the blood cyclosporine level decreased by more than half. Although the blood cyclosporine level decreased after switching to isavuconazole, the dose of cyclosporine was not increased because of its possible effect on renal function. Considering the inhibitory effects on the gastrointestinal tract, a physiologically based pharmacokinetic analysis estimated that isavuconazole increased the area under the curve (AUC) and Cmax of cyclosporine by 1.48-fold and 1.84-fold, respectively, although assuming no change in gastrointestinal metabolism, these effects were minimal. For interaction with voriconazole considering gastrointestinal metabolism, the predicted increases in AUC and Cmax were 3.74-fold and 3.86-fold, respectively. The FDA Adverse Event Reporting System database included 9,144 reports on cyclosporine and 174 on cyclosporine with voriconazole, but none concomitant with isavuconazole. The reporting odds ratios for cyclosporine and isavuconazole could not be assessed because of insufficient reports.ConclusionThe interaction of isavuconazole with cyclosporine was weaker than that with voriconazole. Maintaining a two-hour dosing interval between isavuconazole and cyclosporine may minimize gastrointestinal drug interactions.
Long-term straw return with moderate nitrogen levels reshapes soil bacterial communities in a vertisol
Authors: Guo Zichun , Qian Rui , Li Wei , Ding Tianyu , Gao Lei , Peng Xinhua 
Published: February 2025

IntroductionIncorporating straw into the soil is a sustainable practice that can mitigate some of the adverse effects of excessive N fertilization on soil structure degradation and microbial diversity reduction.MethodsThis objective of this study was to determine the combined effects of straw management (straw return and straw removal) and N fertilization (0, 360, 450, 540, 630, and 720 kg N ha−1 yr.−1) on crop yields, soil properties, and soil microbial communities in a long-term wheat-maize cropping system.Results and discussionThe results showed that moderate N application (N450–N540) with straw return optimized wheat (283.5 kg ha−1) and maize (346.5 kg ha−1) yields, whereas higher N fertilization (N630, N720) led to soil acidification (pH decline of 0.51–1.67 units), irrespective of straw management. Straw return increased soil organic carbon (SOC), total nitrogen (TN), nitrate (NO3−-N), and available potassium (AK), but decreased ammonium (NH4+-N). Bacterial diversity increased at moderate N rates but decreased at higher N rates. Fungal diversity was generally higher under straw removal, with Chaetomiaceae increasing under straw return, whereas Mortierellaceae and Trichocomaceae declined at high N levels. The Mantel test showed a strong correlation between soil pH and bacterial diversity, while fungal composition was influenced by SOC, TN, and NO3−-N. Partial Least Squares Path Modeling (PLS-PM) demonstrated that N fertilization directly and indirectly increased wheat yield through improved soil properties, while straw return enhanced bacterial diversity, indirectly supported wheat yield. This study highlights the importance of balanced N fertilization and straw incorporation in maintaining bacterial community structure, fertility, and long-term crop productivity in intensive cropping systems on Vertisol.
Case Report: A case series on histiocytic sarcoma – various clinical features and patient outcomes
Authors: Nam Hohyung , Min Gi-June , Kim Tong Yoon , Jeon Youngwoo , Cho Seok-Goo 
Published: February 2025

IntroductionHistiocytic sarcoma (HS) is a rare and aggressive hematologic malignancy with a poor prognosis. HS can present with either isolated organ involvement or multi-systemic disease. This case series reports on nine patients with diverse clinical presentations and outcomes.MethodsDiagnoses of HS were confirmed using immunohistochemistry, with markers such as CD68 and lysozyme. Treatment primarily involved anthracycline-based chemotherapy with autologous hematopoietic stem cell transplantation (auto-HSCT) consolidation, and with salvage therapies for resistant or relapsed cases including allogeneic HSCT (allo-HSCT).ResultsDespite intensive treatment, long-term remission was rare. Among the nine patients, three achieved complete remission but relapsed, three had stable disease, two experienced progressive disease, and one is under treatment. No patient maintained complete remission for at least three years, indicating the chemo-resistant nature of HS. Moreover, of three cases in our cohort that achieved complete remission, two declined auto-HSCT owing to the intensity of first-line chemotherapy, and one relapsed shortly after achieving remission. To overcome chemo-resistance, four patients underwent allo-HSCT, and two of them achieved long-term remission.ConclusionThese findings highlight the importance of early diagnosis and suggest potential benefits of either autologous or allogeneic transplantation, while emphasizing the need for further research on treatment protocols.
Engineered exosomes restore miR-508-5p expression in uterine corpus endometrial carcinoma and reduce tumor progression and metastasis by targeting DLL3
Authors: Li Yue-Ying , Liu Hui , Feng Jia-Lu , Tian Wen-Yan , Du Juan , Zhang Li-Ping 
Published: February 2025

IntroductionEndometrial cancer (EC) is a growing global health concern. Understanding the molecular mechanisms driving EC is crucial for developing effective diagnostic and therapeutic strategies. This study investigates the roles of DLL3 and miR-508-5p in EC progression and explores a therapeutic approach using engineered exosomes to modulate their expression.MethodsTCGA data were analyzed, in vitro and in vivo experiments were performed to assess DLL3 and miR-508-5p function, and bioinformatics was used to confirm their interaction. Mesenchymal stem cells (MSCs) were engineered to produce miR-508-5p-overexpressing exosomes, and their therapeutic effects were tested in mouse models.ResultsElevated DLL3 and downregulated miR-508-5p were observed in EC and correlated with poor outcomes. miR-508-5p directly targets DLL3. Engineered exosomes restored miR-508-5p, inhibited DLL3, and reduced tumor growth and metastasis in mouse models.DiscussionThe findings highlight the roles of DLL3 and miR-508-5p in EC. Targeting the miR-508-5p/DLL3 axis via exosome-mediated delivery represents a promising therapeutic strategy for EC.
The influence of genetic polymorphisms on cytokine profiles in pediatric COVID-19: a pilot study
Authors: Kozak Kateryna , Pavlyshyn Halyna , Kamyshnyi Oleksandr , Shevchuk Oksana , Korda Mykhaylo , Vari Sandor G. 
Published: February 2025

IntroductionRecent studies have underscored the importance of genetic factors in predicting COVID-19 susceptibility and severity. While cytokine storms are crucial in disease severity, genetic predisposition significantly influences immune responses. Our study examined genes related to SARS-CoV-2 invasion (ACE2 rs2074192) and interferon-induced immunity (IFNAR2 rs2236757, TYK2 rs2304256, OAS1 rs10774671, OAS3 rs10735079). Additionally, we investigated genes linked to Kawasaki disease (CD40 rs4813003, FCGR2A rs1801274, CASP3 rs113420705) that play roles in immunogenesis.MethodsThe pilot study, which involved 75 pediatric patients aged one month to 17 years [43 patients with active COVID-19, 17 children with multisystem inflammatory syndrome in children (MIS-C), and 15 healthy controls], was conducted in Ternopil, Ukraine. Gene polymorphism was studied for all patients. ELISA kits were used for interleukin studies, including Human IL-1β (Interleukin 1 Beta), Human IL-6 (Interleukin 6), Human IL-8 (Interleukin 8), Human IL-12 (Interleukin 12), Human IFN-α (Interferon Alpha), and Human TNF-α (Tumor Necrosis Factor Alpha). Statistical analysis was performed using IBM SPSS Statistics 21 and GraphPad Prism 8.4.3.ResultsThe analysis identified significant gene-cytokine associations in pediatric COVID-19 patients. The ACE2 rs2074192 T allele correlated with increased IL-1β, IL-6, IL-8, and TNF-α. The IFNAR2 rs2236757 A allele was linked to elevated IL-1β and IL-12 levels and low IFN-α levels, while OAS1 rs10774671 A allele carriers also exhibited lower IFN-α levels. OAS1 rs10774671 was prognostically crucial for determining IL-8 levels in children infected with SARS-CoV-2. OAS3 gene polymorphism rs10735079 was associated with changes in IL-6 levels, precisely a high level. The CD40 rs4813003 T allele increased IFN-α levels, while carriers of allele C had higher levels of IL-12. The results of our study revealed a correlation between IL-8 levels and the FCGR2A gene polymorphism rs1801274 (A/G). The CASP3 gene polymorphism rs113420705 led to an increase in IL-6.ConclusionThese findings enhance our understanding of pediatric COVID-19 and may hold promise for developing targeted interventions and providing a personalized medical approach for each patient.
The effects of training intervention on the prevention of knee joint injuries: a systematic review and meta-analysis
Authors: Zheng Gangbin , Zeng Sai , Li Tiangeng , Guo Liang , Li Ling 
Published: February 2025

ObjectiveTo evaluate the impact of neuromuscular, core strength, balance, and proprioceptive training on preventing knee injuries in young athletes, to identify optimal intervention characteristics.MethodsThis review followed the 2020 guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). A systematic search of English and Chinese literature in databases included PubMed, Web of Science, EBSCO, CNKI, and Wanfang, covering studies published from January 1, 2000, to 12 April 2024. Inclusion criteria targeted randomized controlled trials (RCTs) on training interventions aimed at knee injury prevention among young athletes. The analysis used a random-effects model to pool data from studies meeting our criteria, ensuring a comprehensive evaluation of intervention effectiveness.ResultsA total of 19 randomized controlled trials (RCTs) involving 28,176 subjects were included. The meta-analysis showed that training intervention programs reduced the risk of lower extremity knee injuries by 25% (RR = 0.75, 95% CI: 0.65–0.85). The most notable effects were observed in intervention with exercise duration of 5–15 min, frequencies of 4–5 times per week, and program lengths exceeding 26 weeks.ConclusionThe findings highlight the effectiveness of specific training interventions in reducing knee injury risk among athletes. These insights provide a clear framework for designing training routines that effectively prevent knee injuries.
A taxonomy of athletic values and implications for clinical practice
Authors: Collins Jordan , Merz Zachary C. , Gfeller Jeffrey D. , Ross Michael 
Published: February 2025

IntroductionThe current study surveyed collegiate student-athletes regarding their perceived level of importance surrounding 30 previously derived and empirically obtained athletic values to improve viability of sport psychological practices.MethodsA total of 162 student-athletes enrolled in a private Midwestern NCAA Division 1 university within the United States of America completed tasks asking them to sort and rate utilized values based upon perceived importance surrounding athletic performance and sustained excellence.ResultsResults revealed a hierarchy of athletic values, favoring intrinsic values, useable when emphasizing the importance of value-driven behavior in applied sport psychological practices. Minimal differences were seen across gender, ethnicity, sport classification, and other comparative groups.DiscussionCurrent results may help inform sport psychological practice while working within value-based frameworks.
Problematic online behaviors and their early patterns of co-occurrence in young adults: insights from directed and undirected networks
Authors: Błoch Marta , Misiak Błażej 
Published: February 2025

IntroductionThe study aimed to identify early patterns of clustering within problematic online behaviors (POBs), their dynamics, and associations with several domains of psychopathology in young adults without a history of psychiatric treatment.MethodsParticipants (n = 1441, aged 29.5 ± 6.3 years, 51.4% females) completed self-report measures recording the level of various POBs and several domains of psychopathology. Various approaches were used to analyze the data, including a principal component analysis together with the analysis of partial correlation networks (undirected associations) and Bayesian networks (directed associations).ResultsThree distinct communities of variables were identified, including two communities of POBs (the first one: problematic use of social networking, problematic online shopping, and cyberchondria; the second one: problematic online gaming and gambling, cybersex) and one community of psychopathology. However, correlations between specific POBs were small to moderate. Problematic use of social networking sites, obsessive-compulsive disorder (OCD) symptoms, and problematic online gaming were found to be the bridge nodes. However, OCD symptoms were most likely to predict other POBs (all POBs except for cybersex). In turn, problematic use of social networking sites predicted the greatest number of other POBs (cyberchondria, gaming, and gambling).DiscussionThese findings suggest that POBs tend to cluster into specific comorbidity patterns while remaining distinct entities. The symptoms of OCD are most likely to trigger the occurrence of POBs. Among POBs, problematic use of social networking sites might be most likely to predict the emergence of other POBs.
A machine learning analysis of suicidal ideation and suicide attempt among U.S. youth and young adults from multilevel, longitudinal survey data
Authors: Jacobs Molly M. , Kirby Anne V. , Kramer Jessica M. , Marlow Nicole M. 
Published: February 2025

ObjectivesTo investigate individual, interpersonal, health system, and community factors associated with suicidal ideation (SI) and attempts (SA).MethodsUtilizing nationally representative data from the National Longitudinal Study of Adolescent to Adult Health (7th-12th graders in 1994-95 followed &gt;20 years until 2016-18, N=18,375), least absolute shrinkage selector operator (LASSO) regression determined multilevel predictors of SA and SI. Models comprised full and diagnosis subgroups (ADD/ADHD, depression, PTSD, anxiety, learning disabilities [LD]).ResultsApproximately 2.48% and 8.97% reported SA and SI, respectively. Over 25% had depression, and 20.98% anxiety, 6.42% PTSD, 4.55% ADD/ADHD, and 2.50% LD. LASSO regression identified 20 and 21 factors associated with SA and SI. Individual-level factors associated with SI and SA included educational attainment, substance use, ADD/ADHD, depression, anxiety, and PTSD. Interpersonal-level factors included social support, household size, and parental education, while health system-level factors comprised health care receipt, health insurance, and counseling. The strongest associations were among individual-level factors followed by interpersonal and health system factors.ConclusionsThe distinct factors associated with SI and SA across diagnostic subgroups highlight the importance of targeted, subgroup-specific suicide prevention interventions. These findings emphasize the value of precise, data-driven approaches for suicide prevention among diverse populations and individuals with disabilities across the life-course.