bluuebunny/crossref_metadata_2025_split huggingface dataset:
FDA approves Brixadi, new buprenorphine treatment option
Authors: Knopf Alison 
Published: June 2023

Last month the U.S. Food and Drug Administration approved Brixadi (buprenorphine) extended‐release injection for subcutaneous use to treat moderate to severe opioid use disorder (OUD). Brixadi is available in two formulations: A weekly injection that can be used in patients who have started treatment with a single dose of a transmucosal buprenorphine product or who are already being treated with buprenorphine, and a monthly version for patients already being treated with buprenorphine. It is not for induction or new treatment. The weekly doses are 8 milligrams (mg), 16 mg, 24 mg, 32 mg; and the monthly doses are 64 mg, 96 mg, and 128 mg. The approved weekly formulation in various lower strengths offers a new option for people in recovery who may benefit from a weekly injection to maintain treatment adherence. Brixadi will be available through a risk evaluation and mitigation strategy program and administered only by health care providers in a health care setting. The FDA granted approval of Brixadi to Braeburn Inc.
Enhanced Transdermal Peptide‐Modified Flexible Liposomes for Efficient Percutaneous Delivery of Chrysomycin A to Treat Subcutaneous Melanoma and Intradermal MRSA Infection
Authors: Cai Yue , Chu Yuteng , Gong Yubei , Hong Yulu , Song Fuhang , Wang Hong , Zhang Huawei , Sun Xuanrong 
Published: June 2023

AbstractSuperficial skin diseases, including skin infections and tumors, are common healthcare burdens. In this study, the in vivo activity of chrysomycin A (CA) is explored, and a transdermal liposomal CA formulation is further constructed for the simultaneous treatment of cutaneous melanoma and cutaneous methicillin‐resistant Staphylococcus aureus (MRSA) infection. The prepared liposomes (TD‐LP‐CA) display a strong antitumor effect with an IC50 value of less than 0.1 µm in B16‐F10 cells, suppress the proliferation of MRSA with a minimum inhibitory concentration (MIC) of 1 µm, and eradicate established MRSA biofilms at 10× MIC in vitro. More importantly, TD‐LP‐CA shows enhanced stratum corneum (SC) penetration, reaching more than 500 µm beneath the skin's surface due to modification with the TD peptide, and demonstrates excellent subcutaneous tumor penetration after skin application in vivo. TD‐LP‐CA displays an excellent therapeutic effect against intradermal MRSA infection in mice after topical dermal administration, as well as a moderate inhibitory effect on subcutaneous melanoma with a 75% tumor inhibition rate. The liposomes prepared herein can be a promising carrier for transcutaneous CA transfer for the treatment of superficial diseases such as skin tumors and infections due to their ability to overcome the skin barrier.
Interfacial Passivation Enormously Enhances Electroluminescence of Triphenylphosphine Cu4I4 Cube
Authors: Li Ying , Zhang Xianfa , Man Yi , Xu Shiwei , Zhang Jing , Zhang Guangming , Chen Shuo , Duan Chunbo , Han Chunmiao , Xu Hui 
Published: June 2023

AbstractDefect is one of the key factors limiting optoelectronic performances of organic–inorganic hybrid systems. Although high‐efficiency bidentate ligands based electroluminescent (EL) clusters reported, until present, only few EL clusters based on monodentate ligands are realized since their structural instability induces more surface/interface defects. Herein, this bottleneck is first overcome in virtue of interfacial passivation by electron transporting layers (ETL). Through using TmPyPB with meta‐linked pyridines as ETL, photoluminescent (PL) and EL quantum efficiencies of the simplest monophosphine Cu4I4 cube [TPP]4Cu4I4 are greatly improved by ≈2 and 23 folds, respectively, as well as ≈200 folds increased luminance, corresponding to a huge leap from nearly unlighted (<20 nits) to highly bright (>3000 nits). The passivation effect of TmPyPB on surface defects of cluster layer is embodied as preventing interfacial charge trapping and suppressing exciton nonradiation.
Large‐Area Flexible Thin Film Encapsulation with High Barrier and Super‐Hydrophobic Property
Authors: Li Chao , Yue Shizhong , Tian Wang , Ye Yumin , Liu Jun , Huang Yanbin , Huang Zhitao , Wu Yulin , Sun Jiaqian , Zhao Zeren , Dong Keqian , Liu Kong , Wang Zhijie , Qu Shengchun 
Published: June 2023

AbstractWith the development of optoelectronic devices toward miniaturization, flexibility, and large‐scale integration, conventional submillimeter rigid encapsulation techniques rarely achieve conformational functionality while blocking water and oxygen. At the same time, the sensitivity of electronic devices with organic/metal/semiconductor components to humidity and oxygen severely impairs their operational stability and lifetime. Here, a nanometer to micrometer scale organic/inorganic hybrid thin film encapsulation (TFE) with the self‐cleaning ability for flexible encapsulation is developed. The water vapor transmittance rate of polyethylene terephthalate substrate coated with the TFE is as low as 1.65 × 10−4 g m−2 day−1, and the barrier improvement factor reaches 104 at 38 °C and 90% relative humidity. This value is equivalent to 9.81 × 10−6 g m−2 day−1 at ambient conditions, sufficient to improve the lifetime of water‐sensitive electronic devices. Meanwhile, this TFE shows a super‐hydrophobic performance, with a water contact angle of 168.4°. In addition, the resulting barrier films exhibit outstanding optical properties, with an average optical transmittance of 86.88% in the visible region. This versatile TFE can promote the development of optoelectronic devices toward miniaturization and large‐scale integration in the future.
X‐Ray Visualized Synovial Fluid Carbon Dioxide Sensor for Early Detection of Prosthetic Hip Infections
Authors: Kiridena Sachindra Dulashini , Wijayaratna Uthpala Nawamali , Wang Rong , Anker Jeffrey Nathan 
Published: June 2023

AbstractA radiographically visualized implantable dissolved carbon dioxide (CO2) sensor is developed to non‐invasively detect and monitor hip infections. The sensor is based on a pH‐responsive hydrogel as the sensing material, immersed in a carbonate buffer contained in a capsule with a CO2‐permeable membrane. Dissolved CO2 decreases the buffer pH causing the polyacrylic acid‐based hydrogel to shrink. The hydrogel length is determined using plain radiography by measuring the movement of a radiodense tantalum bead embedded in the hydrogel with respect to a metal wire in the casing. The sensor shows a clear response in the range of 15–115 mm Hg CO2, with a 4.3 mm Hg precision at 15 mm Hg CO2 level and a 6.4‐hour response time. The hydrophobic CO2‐permeable membrane is impermeable to aqueous molecules rendering the CO2 measurement independent of the external solution pH, which can be measured with a separate X‐ray visualized sensor. Separating the sensor from the aqueous environment is also expected to reduce the potential for biofouling and increase longevity. In summary, the first dissolved gas sensor that can be visualized radiographically is described; it has potential applications in detecting and studying implant infection and local carbon tissue CO2 levels.
Micro‐Scaling Metal‐Organic Framework Films through Direct Laser Writing for Chemical Sensing
Authors: Olorunyomi Joseph F. , Singh Ruhani , Nasa Zeyad , Caruso Rachel A. , Doherty Cara M. 
Published: June 2023

AbstractA zeolitic imidazolate framework (ZIF‐8) containing two enzymes that form a cascade biocatalyst has been integrated with 3D structures that are fabricated through a two‐photon polymerization using direct laser writing lithography. Glucose oxidase (GOx) and horseradish peroxidase (HRP) are encapsulated by the biomimetic self‐assembly process of ZIF‐8 to form the GOx/HRP/ZIF‐8 composite which grows in situ on the surface of microprinted carbon‐coated hexagonal substrates (cHS). The GOx/HRP/ZIF‐8/cHS film is applied to glucose detection through enzymatic oxidation of glucose to gluconic acid, forming H2O2, in the presence of GOx and the subsequent reduction of H2O2 to water in the presence of HRP and Amplex Red. This reaction is monitored using fluorimetry as the oxidation of Amplex Red with H2O2 catalyzed by HRP forms red‐emitting resorufin. The GOx/HRP/ZIF‐8/cHS film responds to glucose concentrations with a linear range of 10–200 µm, which correlates to the salivary glucose level in healthy humans. The GOx/HRP/ZIF‐8/cHS film shows more than eight times and 13 times enhanced activity than GOx/HRP/cHS (without ZIF‐8) and GOx/HRP/ZIF‐8 on a non‐3D patterned substrate, respectively. The GOx/HRP/ZIF‐8/cHS film retains more than 80% or 100% of its initial activity after being stored for over 2 months at ≤24 or 4 °C, respectively.
A Spectrofluorometric Method for Real‐Time Graft Assessment and Patient Monitoring
Authors: Huwyler Florian , Eden Janina , Binz Jonas , Cunningham Leslie , Sousa Da Silva Richard X. , Clavien Pierre‐Alain , Dutkowski Philipp , Tibbitt Mark W. , Hefti Max 
Published: June 2023

AbstractBiomarkers are powerful clinical diagnostics and predictors of patient outcome. However, robust measurements often require time and expensive laboratory equipment, which is insufficient to track rapid changes and limits direct use in the operating room. Here, this study presents a portable spectrophotometric device for continuous real‐time measurements of fluorescent and non‐fluorescent biomarkers at the point of care. This study measures the mitochondrial damage biomarker flavin mononucleotide (FMN) in 26 extended criteria human liver grafts undergoing hypothermic oxygenated perfusion to guide clinical graft assessment. Real‐time data identified seven organs unsuitable for transplant that are discarded. The remaining grafts are transplanted and FMN values correlated with post‐transplant indicators of liver function and patient recovery. Further, this study shows how this device can be used to monitor dialysis patients by measuring creatinine in real‐time. Our approach provides a simple method to monitor biomarkers directly within biological fluids to improve organ assessment, patient care, and biomarker discovery.
Recurrence patterns among patients with sinonasal mucosal melanoma: A multi‐institutional study
Authors: Pandrangi Vivek C. , Mace Jess C. , Abiri Arash , Adappa Nithin D. , Beswick Daniel M. , Chang Eugene H. , Eide Jacob G. , Fung Nicholas , Hong Michelle , Johnson Brian J. , Kohanski Michael A. , Kshirsagar Rijul S. , Kuan Edward C. , Le Christopher H. , Lee Jivianne T. , Nabavizadeh Seyed A. , Obermeyer Isaac P. , Palmer James N. , Pinheiro‐Neto Carlos D. , Smith Timothy L. , Snyderman Carl H. , Suh Jeffrey D. , Wang Eric W. , Wang Marilene B. , Choby Garret , Geltzeiler Mathew 
Published: June 2023

AbstractObjectiveTo evaluate recurrence patterns and survival after recurrence among patients with sinonasal mucosal melanoma (SNMM).MethodsThis was a multi‐institutional retrospective review from seven U.S. institutions of patients with SNMM from 1991 to 2022. Recurrence was categorized as local, regional, distant, or multifocal. Kaplan‐Meier tests were used to evaluate disease‐free survival (DFS), overall survival (OS), and post‐recurrence survival (PRS) reported with standard errors (SE) and log‐rank testing used for comparison. Cox‐regression was further used, with hazard ratios (HR) and 95% confidence intervals (CI) reported.ResultsAmong 196 patients with SNMM, there were 146 patients with recurrence (74.5%). Among all patients, 60‐month DFS (SE) was 15.5% (2.9%), 60‐month OS (SE) was 44.7% (3.7%), mean age ± standard deviation at diagnosis was 69.7 ± 12.5 years, and 54.6% were female. In 26 patients who underwent primary treatment of the neck, 60‐month DFS did not differ from no treatment (p > 0.05). Isolated distant recurrence was most common (42.8%), followed by local (28.3%), multifocal (20.7%), and regional recurrence (8.3%). Among patients with regional recurrence in the neck, there was no 60‐month PRS benefit for patients undergoing salvage neck dissection or radiation (p > 0.05). Among patients with distant recurrence, only immunotherapy was associated with improved 12‐month PRS (HR = 0.32, 95% CI = 0.11–0.92, p = 0.034), and no treatment group was associated with improved 24‐ or 60‐month PRS (p > 0.05).ConclusionSNMM is associated with a high recurrence rate and poor survival. Primary treatment of the neck was not associated with reduced recurrence, and immunotherapy for treatment of distant recurrence was associated with increased 12‐month PRS.
The Metabolostasis Network and the Cellular Depository of Aggregation‐Prone Metabolites
Authors: Levkovich Shon A. , Gazit Ehud , Laor Bar‐Yosef Dana 
Published: June 2023

AbstractThe vital role of metabolites across all branches of life and their involvement in various disorders have been investigated for decades. Many metabolites are poorly soluble in water or in physiological buffers and tend to form supramolecular aggregates. On the other hand, in the cell, they should be preserved in a pool and be readily available for the execution of biochemical functions. We thus propose that a quality‐control network, termed “metabolostasis”, has evolved to regulate the storage and retrieval of aggregation‐prone metabolites. Such a system should control metabolite concentration, subcellular localization, supramolecular arrangement, and interaction in dynamic environments, thus enabling normal cellular physiology, healthy development, and preventing disease onset. The paradigm‐shifting concept of metabolostasis calls for a reevaluation of the traditional view of metabolite storage and dynamics in physiology and pathology and proposes unprecedented directions for therapeutic targets under conditions where metabolostasis is imbalanced.
Cobalt‐Catalyzed Asymmetric Remote Borylation of Alkyl Halides
Authors: Zhang Minghao , Ye Zhiyang , Zhao Wanxiang 
Published: June 2023

AbstractEnantioselective functionalization of racemic alkyl halides is an efficient strategy to assemble complex chiral molecules, but remains one of the biggest challenges in organic chemistry. The distant and selective activation of unreactive C−H bonds in alkyl halides has received growing interest as it enables rapid generation of molecular complexity from simple building blocks. Here, we reported a cobalt‐catalyzed remote borylation of alkyl (pseudo)halides (alkyl−X, X=I, Br, Cl, OTs) with pinacolborane (HBpin) and presented a robust approach for the generation of valuable chiral secondary organoboronates from racemic alkyl halides. This migration borylation reaction is compatible with primary, secondary, and tertiary bromides, offering direct access to a broad range of alkylboronates. The extension of this catalytic system to the borylation of aryl halides was also demonstrated. Preliminary mechanistic studies revealed that this remote borylation involved a radical reaction pathway.
Beyond Solvothermal: Alternative Synthetic Methods for Covalent Organic Frameworks
Authors: Hu Jiyun , Huang Zhiyuan , Liu Yi 
Published: June 2023

AbstractCovalent organic frameworks (COFs) are crystalline porous organic materials that hold a wealth of potential applications across various fields. The development of COFs, however, is significantly impeded by the dearth of efficient synthetic methods. The traditional solvothermal approach, while prevalent, is fraught with challenges such as complicated processes, excessive energy consumption, long reaction times, and limited scalability, rendering it unsuitable for practical applications. The quest for simpler, quicker, more energy‐efficient, and environmentally benign synthetic strategies is thus paramount for bridging the gap between academic COF chemistry and industrial application. This Review provides an overview of the recent advances in alternative COF synthetic methods, with a particular emphasis on energy input. We discuss representative examples of COF synthesis facilitated by microwave, ultrasound, mechanic force, light, plasma, electric field, and electron beam. Perspectives on the advantages and limitations of these methods against the traditional solvothermal approach are highlighted.
Green deep‐UV photoresist based on chitosan for microelectronics
Authors: Sysova Olha , Durin Paule , Gablin Corinne , Léonard Didier , Téolis Alexandre , Trombotto Stéphane , Delair Thierry , Berling Dominique , Servin Isabelle , Tiron Raluca , Bazin Arnaud , Leclercq Jean‐Louis , Chevolot Yann , Soppera Olivier 
Published: June 2023

AbstractPhotolithography is a core part in microelectronic processes. This technological step implies the use of numerous hazardous carcinogenic compounds in the formulations, the use of solvents for processing synthetic polymers to obtain micro and nanostructures. We proposed the use of chitosan‐based biosourced water‐soluble resins to significantly reduce the environmental impact of the photolithography step, for 193 nm photolithography. We show in this report that chitosan‐based photoresist is suitable for microelectronic application, and in particular, we could significantly improve photosensitivity by adding a water‐soluble photoacid generator (PAG). UV–visible and Fourier transform infrared‐attenuated total reflectance characterizations reveal an increase of the macromolecular chain scission kinetics in the presence of PAG. Moreover, the local decrease of the pH favors the solubility of chitosan in irradiated areas. Finally, the photolithography tests demonstrate that the dose to clear and the optimal dose for photopatterning are divided by a factor of two. Moreover, the physical etching transfer tests show that the presence of PAG does not decrease the transfer performance, making these aqueous‐based formulated resins still more adapted for the fabrication of microelectronic devices.
Treatment outcomes of advanced/metastatic extramammary Paget's disease in Korean patients: KCSG‐RC20‐06
Authors: Sohn Byeong Seok , Kim Jeongeun , Kim Miso , Hong Jung Yong , Lee Jieun , Park Song Ee , Kim Hyojeong , Lee Hyo Jin , Kang Eun Joo , Lee Soon Il , Lee In Hee , Huh Seok Jae , Jo Jeongmin , Kim Ho Young 
Published: June 2023

AbstractBackgroundExtramammary Paget's disease (EMPD) is rare. There are no standard treatments due to its rarity and few clinical trials.MethodsThe objective of this multicenter study was to investigate treatment outcomes of Korean patients with advanced/metastatic EMPD. Data were collected retrospectively from 14 institutions participating in Korean Cancer Study Group (KCSG) Rare Cancer Committee.ResultsA total of 37 patients were identified. Of these 37 patients, 6 received locoregional therapy as a first‐line treatment. In 31 patients who received systemic chemotherapy as a first‐line treatment, platinum‐based chemotherapy (n = 22) achieved an objective response rate (ORR) of 45.5% and a median progression‐free survival (PFS) of 7.89 months. Taxane‐based chemotherapy (n = 8) achieved an objective response rate of 62.5% and median PFS of 9.73 months. In second‐line chemotherapy, platinum‐based chemotherapy (n = 4) had a disease control rate (DCR) of 75.0% and median PFS of 3.45 months. Taxane‐based chemotherapy (n = 8) had a DCR of 75.0% and a median PFS of 8.67 months. Six patients received anti‐human epidermal growth factor receptor 2 (HER2) antibody during first‐ and second‐line chemotherapy. Overall, systemic chemotherapy combined with anti‐HER2 antibody had an ORR of 100% and a median PFS of 13.31 months. The ORR and PFS with systemic chemotherapy combined with trastuzumab was better than platinum‐ and taxane‐based chemotherapy only.ConclusionsDue to its rarity, advanced or metastatic EMPD still has no established standard treatment. Results of our study indicate that the combination of trastuzumab with taxane has longer survival than trastuzumab monotherapy or conventional platinum‐ or taxane‐based chemotherapy.
Phenolic Characterization and Antioxidant Activity of Chrysanthemum indicum and Opisthopappus Shih during Different Growth Stages
Authors: Wei Dongwei , Sun Wuyong , Huang Mingren , Zeng Xiaoning , Chen Yun , Yuan Zhiliang 
Published: June 2023

AbstractRecently, much attention has been devoted to natural phenolics because of their ideal structure and chemistry for free radical scavenging activities, which may play important roles in long‐term health and a reduction in the risk of developing chronic degenerative diseases. Chrysanthemum indicum (C. indicum) has been widely used as a health food and as a popular herb in China for many centuries. Opisthopappus Shih (O. shih) often takes the place of its related genera, C. indicum, in functional tea or medicine prescriptions in place of origin. In this article, a comparative study on the phenolics and antioxidant activity of C. indicum and O. shih during different growth stages was investigated. The antioxidant properties of plant extracts were tested using DPPH and ABTS assays. The characterization of potential phytochemicals was carried out using Fourier transform infrared (FT‐IR) spectroscopy. Total phenolics (TPC) and total flavonoid content (TFC) were measured using Folin‐Ciocalteu and aluminum chloride colorimetric methods, respectively. An HPLC method was used to simultaneously quantify five phenolic compounds, including chlorogenic acid, luteolin, rutin, quercetin, and apigenin. Results indicated that the Trolox equivalent antioxidant activity (TEAC) values of C. indicum and O. shih had extremely large variations at different growth stages. The most abundant phenolics and potent antioxidant activity of two related plants appear at the early vegetative and then flowering stages. Antioxidant activities and phenolic content of O. shih were higher than those of corresponding organs of C. indicum at the same collection time. The whole plant of O. shih, especially its leaves and flowers, are good candidates for obtaining nutraceuticals and functional food ingredients.
Antiproliferative Activity and Ultrastructural Changes in Promastigote and Amastigote forms of Leishmania amazonensis Caused by Limonene‐Acylthiosemicarbazide Hybrids
Authors: Graça Contato Alex , Kaplum Vanessa , Botura Scariot Débora , Pelegrin Garcia Francielle , Falzirolli Hugo , Vandresen Fábio , Ueda‐Nakamura Tânia , de Oliveira Silva Sueli , Conceição da Silva Cleuza , Vataru Nakamura Celso 
Published: June 2023

AbstractLeishmaniasis is a tropical zoonotic disease. It is found in 98 countries, with an estimated 1.3 million people being affected annually. During the life cycle, the Leishmania parasite alternates between promastigote and amastigote forms. The first line treatment for leishmaniasis are the pentavalent antimonials, such as N‐methylglucamine antimoniate (Glucantime®) and sodium stibogluconate (Pentostam®). These drugs are commonly related to be associated with dangerous side effects such as cardiotoxicity, nephrotoxicity, hepatotoxicity, and pancreatitis. Considering these aspects, this work aimed to obtain a new series of limonene‐acylthiosemicarbazides hybrids as an alternative for the treatment of leishmaniasis. For this, promastigotes, axenic amastigotes, and intracellular amastigotes of Leishmania amazonensis were used in the antiproliferative assay; J774‐A1 macrophages for the cytotoxicity assay; and electron microscopy techniques were performed to analyze the morphology and ultrastructure of parasites. ATZ−S‐04 compound showed the best result in both tests. Its IC50, in promastigotes, axenic amastigotes and intracellular amastigotes was 0.35±0.08 μM, 0.49±0.06 μM, and 15.90±2.88 μM, respectively. Cytotoxicity assay determined a CC50 of 16.10±1.76 μM for the same compound. By electron microscopy, it was observed that ATZ−S‐04 affected mainly the Golgi complex, in addition to morphological changes in promastigote forms of L. amazonensis.