bluuebunny/crossref_metadata_2025_split huggingface dataset:
WITHDRAWN: Physio-metabolic and clinical consequences of wearing face masks -Systematic review with meta-analysis and comprehensive evaluation
Authors: Kisielinski Kai , Hirsch Oliver , Wagner Susanne , Wojtasik Barbara , Funken Stefan , Klosterhalfen Bernd , Manna Soumen Kanti , Prescher Andreas , Sukul Pritam , Sönnichsen Andreas 
Published: December 2022

Abstract

Background: As face masks are a mandatory public health intervention during the COVID-19 pandemic, adverse effects require substantiated investigation.
Methods: A systematic review of 2168 studies yielded 54 publications for synthesis and 37 studies for meta-analysis (on n=8641, m=2482, f=6159, age=34.8±12.5). The median trial duration was only 18 min (IQR=50) for our comprehensive evaluation of mask induced physio-metabolic and clinical outcomes.
Results: We found significant effects in both medical masks with a greater impact regarding the N95. These effects included decreased SpO2 (overall SMD=-0.24, 95%CI=-0.38 to -0.11, p=0.0004) and minute ventilation (SMD=-0.72, 95%CI=-0.99 to -0.46, p<0.00001), simultaneously increased blood-CO2 (SMD=+0.64, 95%CI=0.31–0.96, p=0.0001), heart rate (N95: SMD=+0.22, 95%CI=0.03–0.41, p=0.02), systolic blood pressure (surgical: SMD=+0.21, 95%CI=0.03–0.39, p=0.02), skin temperature (overall SMD=+0.80 95%CI 0.23–1.38, p=0.006) and humidity (SMD +2.24, 95%CI=1.32–3.17, p<0.00001). Effects on exertion (overall SMD=+0.9, surgical=+0.63, N95=+1.19), discomfort (SMD=+1.16), dyspnoea (SMD=+1.46), heat (SMD=+0.70) and humidity (SMD=+0.9) were significant in 373 cases with a robust relationship to mask wearing (p<0.006 to p<0.00001). Pooled symptom prevalence was significant in users (n=8128) for: headache (62%, p<0.00001), acne (38%, p<0.00001), skin irritation (36%, p<0.00001), dyspnoea (33%, p<0.00001), heat (26%, p<0.00001), itching (26%, p<0.00001), voice disorder (23%, p<0.03) and dizziness (5%, p=0.01).
Discussion: Masks interfered with O2-uptake and CO2-release and compromised respiratory compensation. Though evaluated wearing durations do not represent daily/prolonged use, outcomes independently validate mask-induced exhaustion-syndrome (MIES). MIES can have long-term clinical consequences, especially for vulnerable groups.
Conclusion: Face mask side-effects must be assessed (risk-benefit) against the available evidence of their effectiveness against viral transmissions.
Electrochemical treatment of a real textile wastewater using cheap electrodes and improvement in COD removal
Authors: Gümüş Dilek 
Published: December 2022

Abstract
Various types of dyes and other hazardous pollutants used in the textile industry are one of the leading pollutants of surface water. In this study, real textile wastewater was electrochemically treated with two different electrode combinations (graphite/graphite and iron/graphite) by changing the anode electrode type. Then, comparison studies were carried out by adding Fe2+ or H2O2 to these combinations to improve Chemical Oxygen Demand (COD) removal. Current density (5, 7.5, 10 mA cm− 2), initial pH (2.5–8), and electrochemical (EC) oxidation time (0-120 min) were investigated to determine the optimum electrooxidation conditions. The results showed that in the electro-oxidation (EO) process, 100% colour removal, and 75.39% COD degradation efficiencies were achieved at pH 5.5, current density (I) 7.5 mA cm − 2, and electrolysis time (t) 40 min. In the peroxi-coagulation (PC) process, 89.41% colour removal, and 74.28% COD degradation efficiencies were achieved at pH 3, current density 7.5 mA cm − 2, and electrolysis time 120 min. In the EO + Fe+ 2 and PC + H2O2 processes, 99.9% colour removal efficiencies, 96.38 and 90.63% COD degradation efficiencies were reached at pH 3, current density 7.5 mA cm − 2, and electrolysis time 40 min., respectively. In systems using EO, PC, EO + Fe2+and PC + H2O2, energy consumption, and operating cost were estimated as 2.85, 2.34, 0.54, 0.62 kWh m− 3, and 0.304, 0.249, 0.199, 3.466 US$ m− 3, respectively. Among all processes applied in the study, the most efficient one in terms of COD removal performance, energy, and cost is the (EO + Fe2+) system.
First results of durvalumab after chemoradiotherapy in locally advanced non-small-cell lung cancer in Russia
Authors: Yudin D. I. , Laktionov K. K. , Moiseenko F. V. , Ponomarenko D. M. , Chekh E. A. , Chubenko V. A. , Levchenko N. V. , Kozlov V. V. , Stepanova E. О. , Sarantseva K. A. , Denisova E. S. , Ardzinba M. S. , Yukalchuk D. Yu. 
Published: December 2022

Introduction. The addition of durvalumab after chemoradiation therapy in unresectable stage III non-small-cell lung cancer (NSLC) is a new standard of care.Aim. Study the features and outcomes of durvalumab maintenance treatment after chemoradiotherapy in patients with unresectable stage III NSCLC in the real-world clinical practice in Russia.Materials and methods. 50 patients with unresectable III stage NSCLC after concurrent or sequential chemoradiotherapy (CRT) were enrolled in this observational retrospective study. Median follow up time at primary analysis was 12.4 months.Results. A mean age of the patients in the study was 61.2 years (58.4-64.1; 95% CI). Most of the patients had received sequential CRT (76%, n = 38). Median time of durvalumab start from the end of CRT varied from 22 to 50 days (overall - 35 days). Estimated median PFS and OS were 10.86 months (7.78-14.01, 95% CI) and 26 months (20.19-31.81, 95% CI), respectively. There was a trend toward increased PFS in patients with smoking history: 12 months (9.79-14.2; 95% CI) versus 4,9 months (0.0-12.47; 95% CI), p = 0.2. Half of the patients without smoking history (5/10) had targetable mutations (EGFR ex 19, ALK, ROS1, cMET). Most common reported adverse events of special interest were pneumonitis grade 1-2 (36%, n = 18), leading permanent treatment discontinuation to in 6% of patients (n = 3). There were no reported cases of grade 3-4 adverse events.Conclusions. Real-world characteristic of patients in our study were different from PACIFIC trial. Sequential CRT is the most frequent treatment option in locally advanced unresectable NSCLC in Russia. Estimated PFS was shorter than in PACIFIC, but there were less cases of pneumonitis.
Optimal choice of drug antitumor treatment in patients with Fibrolamellar liver carcinoma
Authors: Antonova E. Yu. , Moroz E. A. , Dzhanyan I. A. , Volkov A. Yu. , Laktionov K. K. , Breder V. V. 
Published: December 2022

Introduction. Fibrolamellar hepatocellular carcinoma (FlC) is a rare subtype of hepatocellular carcinoma (HCC). Drug antitumor treatment of FlC has not been studied sufficiently due to the rarity of the pathology and requires further research to choose an effective treatment.Aim. The choice of effective drug antitumor treatment in patients with fibrolamellar liver carcinoma.Materials and methods. The retrospective study included 31 patients with FlC who received drug antitumor therapy at the N.N. Blokhin National Research Center of Oncology of the Ministry of Health of the Russian Federation in the period from 2005 to 2020. The patients were divided into comparison groups: “targeted therapy” (mainly sorafenib), “chemotherapy” (mainly gemcitabine + cisplatin). A comparative intergroup analysis of the effectiveness of drug antitumor treatment in the 1st and 2nd lines of therapy was carried out. Adjuvant chemotherapy was evaluated for time without progression. The correlation of the number of treatment lines in the anamnesis with the prognosis of the disease was also evaluated.Results. Analysis of the effect of adjuvant therapy on relapse-free survival did not prove significant differences between the comparison groups (p = 0.112; log-rank test). Therapy with multikinase inhibitors (mainly sorafenib) allows to achieve a better time without progression compared to chemotherapy (mainly gemcitabine + cisplatin / oxaliplatin) (p = 0.000; log-rank test) in patients in the 1st line of FlC treatment. OS did not significantly differ between the groups (p = 0.417; log-rank test). In line 2, time without progression in patients receiving targeted therapy (p = 0.042; log-rank test) is higher compared to patients receiving chemotherapy in line 2. A longer duration of OV was recorded in the groups of patients who underwent 2 lines of drug antitumor treatment and in the group of 3 or more lines compared with the use of only 1st line of treatment (p = 0.024) and (p = 0.003), respectively.Conclusion. The results of the work demonstrate an advantage in the appointment of targeted therapy as the 1st and 2nd lines of drug antitumor treatment, while the appointment of chemotherapy remains a less prognostically favorable option. Adjuvant therapy administration did not demonstrate a statistically significant difference in relapse-free survival.
Therapy of BRCA-associated metastatic breast cancer. Efficacy and safety of talazoparib in the real-world clinical practice
Authors: Lubennikova E. V. , Kornietskaya A. L. , Dorofeeva N. S. , Rossokha E. I. , Markarova E. V. , Yudina I. V. , Bazaeva I. Y. , Bolotina L. V. , Deshkina T. I. , Zhulikov Ya. A. , Stasenko E. V. , Ustinova T. V. , Tsareva A. S. , Artamonova E. V. 
Published: December 2022

Introduction. PARP inhibitors demonstrated high efficacy in BRCA1/2-associated Her2-negative metastatic breast cancer (BC). They were included in the current standard chemotherapy regimen and recognized as a priority option for the treatment of such tumours following the results of clinical studies.Aim. Review the experience with talazoparib (Talzenna) in the real-world clinical practice of 6 medical centers in Russia.Materials and methods. The review included data from 29 patients with HER2-negative metastatic breast cancer associated with a gBRCA mutation, who have been receiving talazoparib therapy in 6 medical centers of Russia since April 2021. Talazoparib was given at the standard dose 1 mg once daily, the dose was reduced, if any adverse event developed.Results. The median age of the patients was 50 years. 23 patients had a BRCA1 mutation, 5 patients had a BRCA2 mutation and one of the patients had a PALB2 mutation. Prior to starting talazoparib therapy, patients had received up to 9 lines of therapy for metastatic disease, the median was 1 line. The median follow-up period at that time was only 4.6 months. The median recurrence-free survival (RFS) was not reached. Progression was observed in 10 patients with a treatment period of 1 to 7.5 months, 19 patients continued to receive PARP inhibitor therapy without signs of disease progression, with a treatment period of 2 to 18 months. The objective response rate (ORR) was 57.2%, the clinical efficacy was confirmed in 85.7% of cases. The subgroup analysis showed that the lowest efficacy of therapy was reported in the group of patients, who had received prior therapy with platinum-based drugs, the median progression-free time (mPFT) was 4.5 months. (95% CI: 1.79-9.2). While for patients who had not received the prior platinum drug regimens, the median was not reached. Haematologic toxicities were common adverse events (AEs) for the talazoparib therapy, which were reported in 34.5% of cases. Transfusions of blood components were required in 3 patients, one of them required them repeatedly. All dose modifications were due to hematological toxicities. 7 patients (24.1%) required a dose reduction and 3 patients (10.3%) - repeated dose reduction.Conclusions. Testing for BRCA1/2 mutations in Her2-negative mBC should be a mandatory diagnostic procedure. Talazoparib therapy is an effective and safe treatment option for patients with gBRCAmut HER2-mBC.
Real clinical practice patterns of palbociclib usage in Russian Federation
Authors: Frolova M. A. , Stenina M. В. 
Published: December 2022

Introduction. Current treatment of metastatic luminal Her2-negative breast cancer includes combination of endocrine therapy (ET) with CDK4/6 inhibitors. This type of therapy demonstrated impressive efficacy over mono ET in early lines of treatment in phase III randomized clinical trials. Treatment patterns in real clinical practice (RCP) are of great interest. We represent the first available local data for all CDK 4/6 inhibitors in RCP in Russian Federation in accordance with the number of patients (pts).Aim. Analysis of the patterns of palbociclib administration in RCP.Materials and methods. One hundred and 5 pts from 12 regions of Russian Federation were included in this analysis and received palbociclib in combination with ET from 2017 to 2020. Median age was 57 years (29-75), 31/105 (29.5%) of pts were < 50. De novo metastatic disease was observed in 16 (15.2%) pts, 89 pts progressed after radical treatment. Visceral metastases (mts) at palbociclib initiation had 61/105 (58.1%) of pts.Results. Only 22/105 (21%) of pts received palbociclib as 1st line treatment of metastatic disease. The majority of pts was treated with palbociclib in 2nd and 3rd lines (28.5% and 30.5% respectively). In 26/105 (24.8%) pts palbociclib was combined with aromatase inhibitors, in other cases - with fulvestrant. Median follow-up time was 6.5 (1.1-31.9) months, median progression free survival - 6.0 (1.0-28.0) months. Most common adverse events (AE) were leukopenia, neutropenia and thrombocytopenia. Only in 3 cases palbociclib was completely stopped due to toxicity.Conclusions. Our data indicates that there is a need to move palbociclib initiation in first two lines of treatment to get maximal improvement in survival and to increase its usage in young women.
Osmanlı’dan Cumhuriyete Anadolu’da Karga İstilaları ve Kargalara Karşı Yürütülen Mücadeleler (1860-1965)
Authors: OLGUN Said 
Published: December 2022

Ekonomisi tarıma dayanan toplumlar çekirge ve domuz başta olmak üzere tarımsal üretime zarar veren çeşitli hayvanlara karşı yüzyıllar boyunca mücadele etmek zorunda kalmışlardır. Tarlalardaki ekinlere, bağ ve bahçelerdeki meyvelere zarar veren kargalar da tarım toplumlarının mücadele ettiği hayvanlardan biri olagelmiştir. Bu mücadele çoğu zaman çiftçiler ve halk eliyle sürdürülmüş; yerel ve mahalli yönetimler almış oldukları kararlar ve çıkarmış oldukları kanunlarla mücadelenin yasal ve idarî zeminini hazırlamışlardır. İdarî ve yasal düzenlemelerle mücadelenin kimler tarafından hangi şartlar altında nasıl gerçekleştirileceği belirlenmiş; ödül ve ceza mekanizması işletilerek halkın yürütülen mücadeleye katılımı teşvik edilmiştir. Kargalar yalnızca kırsal alanda geçimini çiftçilikle temin eden köylülerin değil aynı zamanda şehir ve şehirliler için de büyük bir sorun olabilmişlerdir.
Çalışmanın ilk kısmında Osmanlı Arşiv belgeleri üzerinden Osmanlı Devleti’nin son dönemlerinde Edirne ve İstanbul çevresinde karşılaşılan karga istilaları ve bunlara karşı alınan önlemler ve yürütülen mücadelelere değinilmiştir. İkinci kısımda ise Cumhuriyet döneminde Anadolu’nun çeşitli şehirlerinde yapılan mücadeleler dönemin ulusal gazeteleri ve Meclis Tutanakları üzerinden aktarılmaya ve değerlendirilmeye çalışılmıştır. Bu çalışmada Anadolu topraklarında bir zararlı olarak kargalara karşı yürütülen mücadeleler, halkın şikayetleri, alınan önlemler, idarî ve yasal düzenlemeler ile mücadele yöntemleri ve elde edilen sonuçlar aracılığıyla anlatılmaya ve değerlendirilmeye çalışılmıştır.
Anadolu Türk Beyliklerinde Askerî Gelenekler-1 (Savaş Öncesinde ve Savaş Sırasında Uygulanan Gelenekler)
Authors: KAYA Kerim Köksal 
Published: December 2022

İkinci devir Anadolu Türk beylikleri dönemi Anadolu Türk tarihinin önemli bir merhalesini teşkil etmekle birlikte genellikle bu hususta yapılan çalışmalar beyliklerin siyasî hayatları ve sanat tarihleri üzerinde durmaktadır. Bununla birlikte kaynakların sınırlılığına rağmen bu dönemin tarihi biraz irdelendiğinde Türk gelenekleri ve kültür tarihine dair son derece kıymetli malumata ulaşmak mümkündür. Nitekim ilgili beylikler Orta Asya Türk gelenekleri ve kültürüyle, ilk Müslüman Türk devletlerinin geleneklerinin ve kültürlerinin Anadolu üzerindeki taşıyıcıları ve hâmileri olmuştur. Yapılan bu çalışmada Türkiye Selçuklularının yıkılış sürecine girmesiyle birlikte Anadolu’nun muhtelif sahalarında ortaya çıkan beyliklerin askerî yapılarının bir tezahürü olan askerî gelenekleri ele alınacaktır. Bu konu hakkında yapılacak tam çalışma bir makale çalışması için oldukça hacimli olacağından burada sadece ilgili Anadolu Türk beyliklerinin savaş öncesinde ve savaş sırasında uyguladığı askerî gelenekler hakkında bazı örneklerle değerlendirmeler yapılacaktır.
Çalışma kapsamındaki beyliklerin ilk zamanlarında Türkiye Selçuklularına bağlı uç beylikleri oldukları göz önüne alındığında zaten onların mevcudiyetinin asıl amacının askerî faaliyetler olduğu (sınırları korumak, gazalara çıkmak vb.) anlaşılmaktadır. Bu amaç doğrultusunda teşkil edilen ve başlıca faaliyetleri askerlikle ilgili olan beyliklerin Türk askerî kültüründen uzak kalması pek olası değildir. Bu bağlamda Anadolu Türk beyleri hem Türkiye Selçuklularının hâkimiyeti altında ve hem de bağımsız oldukları dönemde sefer ve savaşların her aşamasında Türk askerî kültürüne sahip çıkmışlar ve bu kültürü zenginleştirmişlerdir.
Implication of Personalized Advertising on Personal Data: A Legal Analysis of the EU General Data Protection Regulation
Authors: Basarudin Noor Ashikin , Raji Ridwan Adetunji 
Published: December 2022

p>The accelerating emergence of personalised advertising is mostly driven by data. Accordingly, algorithmic profiling has become a constant experience for every online user in predicting preference and interest. The profiling process raises several issues of human privacy and personal data invasion. Therefore, this study adopts the doctrinal legal method through the analysis of International Instruments and the European Union General Data Protection Regulation as legal avenue to safeguard and protect online activities of the data subjects. The findings of this paper discuss the main principles to be observed by the data controller in ensuring the legality of personal data profiling. This paper suggests the profiling process to be design-based security due to unavailability of system procedure to human knowledge.
Keywords: Personalised Advertising; Algorithmic Targeting; Personal Data Profiling; EU General Data Protection Regulation
eISSN: 2398-4287 © 2022. The Authors. Published for AMER ABRA cE-Bs by e-International Publishing House, Ltd., UK. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians/Africans/Arabians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia.
DOI: https://doi.org/10.21834/ebpj.v7i22.4160
Environmental Noise in Residential Environments: The Case for Quality of Life in Minna, Nigeria
Authors: Akande Oluwafemi Kehinde , Yusuf Abdullahi 
Published: December 2022

Environmental noise pollution lowers the quality of life and is a public health concern in residential areas. In Minna, Nigeria, the effects of exposure to noise pollution on inhabitants' health and well-being were examined in this study. The indicated maximum limits for tolerable noise levels for quality of life in a home context were exceeded by the noise data measured using a sound level meter, a hand-held geographic positioning system, and a structured questionnaire (N = 880). The study recommended the design of noise-absorbing buildings, improved urban and infrastructure planning, and noise-regulating measures
for a considerable increase in the quality of life of people.
Keywords: Environmental noise; Public health; Quality life; Residential environment
eISSN: 2398-4287 © 2022. The Authors. Published for AMER ABRA cE-Bs by e-International Publishing House, Ltd., UK. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians/Africans/Arabians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia.
DOI: https://doi.org/10.21834/ebpj.v7i22.4161
Libras na educação infantil
Authors: Carvalho Andréa Guimarães , Brasil Ynara Julia dos Santos 
Published: December 2022

Este artigo tem como objetivo propor ou sugerir critérios que direcionam a elaboração de um planejamento de ensino de Libras seja L1 ou L2, mais adequado e significativo para crianças no ambiente escolar. As investigações, de caráter qualitativo e bibliográfico geraram reflexões e perspectivas que atualmente são apresentadas na literatura que envolve essa temática na área da educação infantil. Para tanto, as discussões foram embasadas em teóricos como Quadro e Cruz (2011), Gesser (2010), Vygotsky (1997) dentre outros. Os resultados mostraram que na elaboração de um planejamento de ensino de Libras, L1 ou L2 para crianças sugere-se como critérios: considerar os processos de aquisição de língua e desenvolvimento da linguagem; em qual estágio de desenvolvimento e cognição as crianças estão, para identificar o que está adequado e o que necessita ser adquirido e, também, a quantidade de crianças ouvintes e surdas no contexto escolar, observando se será preciso mais abordagens metodológicas de ensino como L1 ou como L2. Além disso, constatou-se que na produção acadêmica na área da Libras, pouquíssimos foram os trabalhos encontrados que norteiam a prática de ensino de Libras para a educação infantil.
Palavras-chave: libras na educação infantil, planejamento no ensino de Libras, educação e desenvolvimento de lingua(gem).
IMPLEMENTASI PEMBELAJARAN MATEMATIKA PADA MASA PANDEMI COVID-19 KELAS IV MI MUHAMMADIYAH BENER
Authors: Astuti Aprilia Fajar 
Published: December 2022

Coronavirus membawa dampak bagi semua sektor yang ada di Indonesia termasuk sektor pendidikan, yang menyebabkan proses belajar mengajar tatap muka untuk sementara dihentikan karena pemerintah mengambil kebijakan menutup sekolah untuk memutus rantai penyebaran Covid-19. Penutupan sekolah tidak hanya terjadi di Indonesia tetapi hampir diseluruh dunia. Selain menutup sekolah, pemerintah juga membatasi aktivitas di luar rumah untuk menghindari kerumunan banyak orang, dengan kebijakan tersebut proses pembelajaran tatap muka disekolah beralih menjadi pembelajaran di rumah atau pembelajaran daring baik tingkat sekolah maupun perguruan tinggi. Penelitian ini bertujuan untuk 1) mendeskripsikan perencanaan pembelajaran, 2) mendeskripsikan proses pembelajaran, 3) mendeskripsikan evaluasi pembelajaran selama pandemi Covid-19 pada mata pelajaran matematika kelas IV di MI Muhammadiyah Bener. Jenis penelitian ini menggunakan metode penelitian kualitatif dengan jenis penelitian deskriptif kualitatif. Pengumpulan data menggunakan metode wawancara, observasi, dokumentasi dan catatan lapangan untuk mengumpulkan informasi terkait pembelajaran daring pada mata pelajaran matematika di masa pandemi Covid-19. Hasil penelitian menunjukkan bahwa 1) perencanaan pembelajaran matematika yang dibuat guru sebelum pembelajaran yaitu meliputi pembuatan silabus dan rencana pelaksanaan pembelajaran (RPP) 2) proses pembelajaran pada masa pandemi Covid-19 dilakukan secara daring melalui aplikasi whatsaap, dengan guru mengirimkan video pembelajaran dan peserta didik memahami video tersebut. Proses pembelajaran dilakukan dengan tiga tahapan, yaitu kegiatan pendahuluan, kegiatan inti, dan kegiatan penutup, 3) proses evaluasi tetap dilaksanakan, namun hanya aspek kognitif saja yang dapat dilakukan evaluasi secara maksimal.