bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of Ferroptosis Inducers on Chronic Radiation-exposed Survivor Glioblastoma
Cells
Authors: Erdem İlknur Sur 
Published: August 2023

Introduction:
The median survival of patients diagnosed with glioblastoma is very poor, despite efforts to
improve the therapeutic effects of surgery, followed by treatment with temozolomide (TMZ) and ionizing radiation
(IR). The utilization of TMZ or IR survivor cell models has enhanced the understanding of glioblastoma biology and
the development of novel therapeutic strategies. In this present study, naïve U373 and clinically relevant U373 IRsurvivor
(Surv) cells were used, as the IR-Surv cell model mimics the chronic long-term exposure to standardized
radiotherapy for patients with glioblastoma in the clinic. As the role of ferroptosis in the IR survivor cell model has not
previously been reported, we aimed to clarify its involvement in the clinically relevant IR-Surv glioblastoma model

Methods:
Transcriptomic alterations of ferroptosis-related genes were studied on naïve U373 and IR-Surv cell populations.
To determine the effects of glutathione peroxidase inhibitors, ferroptosis-inducing agent 56 (FIN56) and Ras synthetic
lethal 3 (RSL3), on the cells, several properties were assessed, including colony formation, cell viability and lipid
peroxidation.

Results:
Results from the transcriptomic analysis identified ferroptosis as a critical mechanism after radiation exposure in
glioblastoma. Our findings also identified the role of ferroptosis inducers (FINs) in IR-survivor cells and suggested using
FINs to treat glioblastoma.

Conclusion:
FINs serve an important role in radioresistant cells; thus, the results of the present study may contribute to
improving survival in patients with glioblastoma.
The Jiangtang Tongmai Prescription Inhibits Inflammation and Fibrosis
of Lung Fibroblast Autophagy Induced by Hyperglycemia by Regulating
CAV1 Expression
Authors: Ding Nian , Fan Yanbo , Zheng Chenghong 
Published: August 2023

Objective:
The lung is one of the target organs of diabetes. This study aimed to probe the
protective mechanism of Jiangtang Tongmai Prescription (JTTMP) against diabetic lung injury.

Methods:
JTTMP-containing serum was collected, and a high glucose and high-fat diabetic cell
model was established. The cells were treated with a drug-containing serum or a CAV1-associated
vector. Transfection efficiency was measured by qRT-PCR and western blot, the cell proliferative
capacity was tested by CCK-8 assay, and the expression of autophagosome marker LC3B was
measured by immunophluorescence assay. Expression levels of the autophagy markers LC3B, p62,
and Beclin-1, and the expression levels of the fibrosis markers α-SMA, FN-1, and TGF-β1 were
determined by western blot, and the levels of inflammatory factors TNF-α and IL-1β in the supernatants
were assessed by ELISA.

Results:
In high glucose and high fat-induced MRC-5 cells, JTTMP-containing serum impeded the
abnormal cell proliferation and the expression levels of autophagy markers, fibrosis markers, as
well as inflammatory factors. CAV1 expression was decreased in MRC-5 cells treated with
JTTMP-containing serum. In MRC-5 cells upon transfection with the CAV1 overexpression vector
and treatment with JTTMP-containing serum, increased cell proliferation, increased LC3B, p62,
Beclin-1, α-SMA, FN-1, and TGF-β1, TNF-α, and IL-1β levels were found compared with cells
treated with JTTMP-containing serum alone.

Conclusion:
This study suggests that JTTMP suppresses CAV1 expression to attenuate diabetic
lung injury by reducing abnormal proliferation and autophagy, and reducing levels of fibrosis and
inflammation.
Applications of the Natural Language Processing Tool ChatGPT in Clinical Practice: Comparative Study and Augmented Systematic Review
Authors: Schopow Nikolas , Osterhoff Georg , Baur David 
Published: August 2023

Background
This research integrates a comparative analysis of the performance of human researchers and OpenAI's ChatGPT in systematic review tasks and describes an assessment of the application of natural language processing (NLP) models in clinical practice through a review of 5 studies.

Objective
This study aimed to evaluate the reliability between ChatGPT and human researchers in extracting key information from clinical articles, and to investigate the practical use of NLP in clinical settings as evidenced by selected studies.

Methods
The study design comprised a systematic review of clinical articles executed independently by human researchers and ChatGPT. The level of agreement between and within raters for parameter extraction was assessed using the Fleiss and Cohen κ statistics.

Results
The comparative analysis revealed a high degree of concordance between ChatGPT and human researchers for most parameters, with less agreement for study design, clinical task, and clinical implementation. The review identified 5 significant studies that demonstrated the diverse applications of NLP in clinical settings. These studies’ findings highlight the potential of NLP to improve clinical efficiency and patient outcomes in various contexts, from enhancing allergy detection and classification to improving quality metrics in psychotherapy treatments for veterans with posttraumatic stress disorder.

Conclusions
Our findings underscore the potential of NLP models, including ChatGPT, in performing systematic reviews and other clinical tasks. Despite certain limitations, NLP models present a promising avenue for enhancing health care efficiency and accuracy. Future studies must focus on broadening the range of clinical applications and exploring the ethical considerations of implementing NLP applications in health care settings.
JUSTIFIKASI EFISIENSI SEBAGAI ALASAN PEMUTUSAN HUBUNGAN KERJA
Authors: Santoso Budi 
Published: August 2023

Termination of employment by reason of efficiency without the enterprise has to be closed down is no tregulated in Act Number 13 Year 2003 concerning Manpower. However, based on the Act, reason ofefficiency is not one of the prohibited reasons of termination. Through the interpretation of Article 151 and 153 of the Act, the employer may terminate the employment by reason of efficiency provided thatthe redundancy, the disclosure of information, efforts to prevent termination of employment, negotiation with workers’ representatives and based on good faith. Pemutusan hubungan kerja dengan alasan efisiensi tanpa tutupnya perusahaan tidak diatur dalam UU No. 13 Tahun 2003. Namun demikian, berdasarkan Undang-Undang tersebut, alasan efisiensi yang merupakan bentuk dari alasan ekonomi bukan merupakan salah satu alasan yang dilarang dalam pemutusan hubungan kerja. Melalui penafsiran Pasal 151 dan 153 UU No. 13 Tahun 2003, pengusaha dapat memutuskan hubungan kerja atas alasan efisiensi dengan syarat adanya kelebihan jumlah pekerja, adanya keterbukaan informasi, adanya upaya-upaya pencegahan agar pemutusan hubungan kerja tidak terjadi, dan musyawarah dengan perwakilan pekerja serta dilandasi oleh itikad baik.
HAKIKAT KEILMUAN ILMU HUKUM DITINJAU DARI SUDUT FILSAFAT ILMU DAN TEORI ILMU HUKUM
Authors: Tutik Titik Triwulan 
Published: August 2023

The essence of jurisprudence can be seen from two perspectives; perspective of philosophy of science and legal theory. From philosophical point of view, the term of science has two meanings; that is as a product and as a process. As a product, science is knowledge which has been verified in certain disciplines and systemized. Legal theory sees that jurisprudence has a specific character (sui generis), which is normatif. Therefore, jurisprudence remains acceptable as a science while respecting the character of jurisprudence. Hakikat keilmuan ilmu hukum dapat ditinjau dari sudut filsafat ilmu dan teori hukum. Dari sudut filsafat, istilah ilmu (science) menyandang dua makna, yaitu sebagai produk dan sebagai proses. Sebagai produk, ilmu adalah pengetahuan yang sudah terkaji kebenarannya dalam bidang tertentu dan tersusun dalam suatu sistem. Teori hukum memandang, bahwa ilmu hukum memiliki karakter yang khas (sui generis), yaitu sifatnya yang normatif. Berdasarkan kenyataan demikian, maka Ilmu Hukum tetap diterima sebagai ilmu dengan tetap menghormati karakter ilmu hukum yang merupakan kepribadian ilmu hukum.
‘MODERN ARBITRATION LEGISLATION’: A COMPARISON BETWEEN AUSTRALIAN AND INDONESIAN LAWS
Authors: Shahrullah Rina Shahriyani 
Published: August 2023

This research analyzes Law No. 30 of 1999 of Indonesia to ascertain whether this Indonesian law constitutes modern arbitration legislation in the context of international commercial arbitration. Law No. 30 of 1999 will be compared with the International Arbitration Act 1974 (Cth) and the International Arbitration Amendment Act 2010 (Cth) of Australia. In this research, the author finds the Model Law should be adopted by Indonesia to modernize the country’s arbitration law in order for it to more acceptable in the practices of international commersial arbitration to day. Furthermore, the adaption of the Model Law also assists to clarity the Indonesian approach to the appircation of public policy principle which can be used to resest arbitral awards in Indonesia. Penelitian ini mempelajari Undang-undang Nomor 30 Tahun 1999 untuk mengetahui apakah hukum di Indonesia tergolong ke dalam aturan arbitrase modern dalam arbitrase komersial internasional. Penulis membandingkan Undang-undang Nomor 30 Tahun 1999 dengan International Arbitration Act 1974 (Cth) dan International Arbitration Amendment Act 2010 (Cth) di Australia. Dalam penelitian ini, penulis menemukan bahwa Model Law dapat diadopsi oleh Indonesia untuk memodernisasikan hukum arbitrasenya agar dapat lebih diterima dalam praktek arbitrase niaga internasional. Diadopsinya Model Law dapat juga membantu mengklarifikasi pendekatan Indonesia terhadap aplikasi kebijakan publik yang dapat dipergunakan untuk menentang putusan arbitrase di Indonesia.
WARALABA SEBAGAI INSTRUMEN PENGENTASAN KEMISKINAN DI INDONESIA
Authors: Imanullah Moch. Najib 
Published: August 2023

The objective of this research is to look for the justification of a new theory that uses franchise as an alternative to alleviate poverty in Indonesia, particularly absolute poverty in urban cities. Local wisdom inspires Indonesia’s juridical design for franchise laws that supports the franchise industry. This research finds that the theory that franchise can be applied as an instrument to alleviate poverty can be accepted. However, the application of the franchise industry as an instrument to alleviate poverty is ineffective because of a several factors, such as the vagueness of statutory regulations, unfavourable social culture, and the weak government supervision. Penelitian ini bertujuan untuk mencari justifikasi teori baru bahwa waralaba dapat dipergunakan sebagai salah satu instrumen untuk pengentasan kemiskinan di Indonesia, khususnya kemiskinan absolut yang terjadi di perkotaan. Justifikasi tersebut meliputi adanya kearifan lokal sebagai inspirasi yang diterapkan dalam waralaba dan desain yuridis peraturan perundang-undangan di Indonesia yang mendukung waralaba. Hasil dari penelitian ini dapat disimpulkan bahwa teori yang mengatakan bahwa waralaba dapat dipergunakan sebagai salah satu instrumen untuk mengentaskan kemiskinan di Indonesia dapat diterima. Akan tetapi, penggunaan waralaba sebagai instrumen untuk mengentaskan kemiskinan belum efektif dikarenakan beberapa faktor, seperti faktor peraturan perundang-undangan yang tidak tegas, kultur masyarakat, dan lemahnya pengawasan pemerintah.
KEARIFAN LOKAL MASYARAKAT TAU TAA WANA BULANG DALAM MENGKONSERVASI HUTAN DI PROPINSI SULAWESI TENGAH
Authors: Sahlan Mr. 
Published: August 2023

This study found that the local community of Tau Taa Wana Bulang had local wisdoms favouring the forest balance and continuance that would encourage the people to be involved actively and collectively in the process of conserving the surrounding community forest. The factor of age, income, education, experience, attitude, conception, and motivation were proven collectively to have the significant effect to the cultural participation based on local wisdom of the community of Wana (R2= 0.92). The cultural implementation was found in the amount of traditional ceremonies having influences directly and indirectly to the conservation of surrounding forests. Hasil penelitian ini menunjukkan bahwa masyarakat lokal Tau Taa Wana Bulang memiliki kearifan lokal yang mengedepankan prinsip keseimbangan dan keberlanjutan hutan, yang dapat mendorong warganya terlibat secara sukarela dan kolektif dalam melestarikan hutan kemasyarakatan di sekitarnya. Faktor umur, pendapatan, pendidikan, pengalaman, sikap, wawasan dan motivasi telah terbukti bersama-sama memiliki pengaruh signifikan terhadap partisipasi kultural berbasis-kearifan lokal masyarakat Wana (R2= 0.92). praktik kultural ini terwujud dalam sejumlah upacara tradisional yang secara langsung atau tidak langsung berdampak pada pelestarian hutan di sekitarnya.
ASAS KESEIMBANGAN DALAM KONSEP RANCANGAN UNDANG-UNDANG KITAB UNDANG-UNDANG HUKUM PIDANA
Authors: Gunarto Marcus Priyo 
Published: August 2023

Criminal law reform by replacing the old penal code is intended to ensure that the applicable criminal law is consistent with the value of Indonesian nation. Therefore, review and re-establishment of criminal law that is based on the central Indonesian values of socio-political, socio-philosophical, and sociocultural must be conducted. In accordance with the Indonesian nation’s character who put individual and social interest in an equilibrium, a monodualistic balance must be the foundation of the concept of criminal action, criminal responsibility, and punishment. Pembaharuan hukum pidana dengan mengganti KUHP yang lama dengan KUHP yang baru dimaksudkan agar hukum pidana yang berlaku sesuai dengan sistem nilai yang dianut oleh bangsa Indonesia. Sehubungan dengan hal tersebut, pembaharuan hukum pidana dilakukan peninjauan dan pembentukan kembali hukum pidana yang sesuai dengan nilai-nilai sentral sosio-politik, sosio-filosofik, dan nilai-nilai sosio-kultural masyarakat Indonesia. Sesuai dengan karakter bangsa Indonesia yang menempatkan kepentingan individu dan kepentingan sosial secara berimbang, maka keseimbangan monodualis mendasari pengaturan tentang perbuatan pidana, pertanggungjawaban, pidana dan pemidanaan.
Pelaksanaan Peraturan Partisipasi Masyarakat dalam Penanggulangan Bencana Gunung Api Merapi
Authors: Triyana Heribertus Jaka , Wibowo Richo Andi 
Published: August 2023

This paper describes the implementation of the public participation rule in the disaster management of Merapi volcano. The regulation desires for a shift of paradigm from centralized disaster management to participative disaster management. This study shows the government has not shifted from the old paradigm of centralized disaster management. Tulisan ini menggambarkan pelaksanaan aturan partisipasi masyarakat dalam penanggulangan bencana gunung api Merapi. Peraturan menginginkan pergeseran paradigma penanggulangan bencana dari sentralistik ke penanggulangan bencana yang partisipatoris. Penelitian ini menunjukkan Pemerintah belum sepenuhnya beralih dari paradigma penanggulangan bencana sentralistis.
Penerapan Hukum Pidana dalam Perkara Pencemaran Nama Baik
Authors: Supriyadi Mr. 
Published: August 2023

Libel is criminalised under Article 310 Penal Code and Art. 27(3) and 45(1) Act 11/2008. Supreme Court commonly hands suspended sentence for offenders found guilty of libel. Judges should consider freedom of speech and journalism, consumer and patient rights, and rights to gain information before rendering guilty verdicts. Pencemaran nama baik diatur dalam Pasal 310 KUHP serta Pasal 27(3) dan 45(1) UU 11/2008. Mahkamah Agung biasanya menjatuhkan pidana bersyarat bagi terdakwa pencemaran nama baik. Hakim harus mempertimbangkan kemerdekaan pers dan berpendapat, hak konsumen dan pasien, serta hak untuk mendapatkan informasi sebelum menjatuhkan putusan pemidanaan.
Efektivitas Pembentukan Badan Arbitrase Pasar Modal (BAPMI) dalam Menunjang Kegiatan Pasar Modal
Authors: Herliana Mrs. , Nurhayati Irna 
Published: August 2023

Despite the high expectation for the Indonesian Capital Market Arbitration Board (BAPMI) to resolve financial market dispute in an efficient manner, it has settled very few disputes since its establishment. We find this low number of arbitration settlement roots from both institutional factors and capital market players. Walaupun kehadiran Badan Arbitrase Pasar Modal disebut-sebut bermanfaat bagi industri pasar modal karena mampu menyelesaikan sengketa secara efisien, ternyata belum banyak sengketa yang diselesaikan oleh BAPMI. Hasil penelitian menemukan bahwa minimnya jumlah sengketa yang diselesaikan melalui arbitrase di BAPMI disebabkan karena faktor institusi dan pelaku pasar modal sendiri.
Mengembalikan Pelaksanaan Peninjauan Kembali Sesuai Asas Hukum
Authors: Gunarto Marcus Priyo 
Published: August 2023

This study analyzes the inconsistency of the Supreme Court when trying review appeals. Once, it turned down prosecuting attorney’s appeal because Article 263 KUHAP only recognizes the defendants or their inheri­tors to file such request. However in another ruling, the Court granted the appeal ‘for the sake of public interest’. Studi ini mencermati ketidakkonsistenan Mahkamah Agung dalam mengadili pen­injauan kembali. Dalam satu perkara, Mahkamah menolak permohonan penin­jauan kembali dari jaksa karena Pasal 263 KUHAP membatasi hanya terpidana atau ahli warisnya saja sebagai pihak yang dapat memohon peninjauan kembali. Namun dalam perkara lain, Mahkamah mengabul­kan permohonan jaksa demi ‘melindungi kepentingan umum’.
Pertanggungjawaban Dewan Pengurus Syariah sebagai Otoritas Pengawas Kepatuhan Syariah bagi Bank Syariah
Authors: Ilhami Haniah 
Published: August 2023

Sharia Compliance is important in the management and operational of sharia banks, therefore a sharia supervisory board (Dewan Pengawas Syariah, DPS) is imperative to be established in every sharia-based banks. The problem is, Indonesian sharia banking laws do not clearly regulate the supervisory function of this DPS, hence this study. Kepatuhan Syariah adalah elemen penting dalam pengelolaan dan operasional bank syariah, dengan demikian sebuah dewan yang bertugas mengawasi penerapan prinsip syariah (Dewan Pengawas Syariah, DPS) harus dibentuk di setiap bank berbasis syariah. Fokus penelitian ini adalah hukum perbankan syariah di Indonesia yang belum secara jelas mengatur fungsi pengawasan DPS.
Masalah Transportasi Kota Dilihat dengan Pendekatan Hukum, Sosial dan Budaya
Authors: Hendratno Edie Toet 
Published: August 2023

The 1992 Traffic and Transportation Act perceives transportation as an important and strategic tool to improve economic development. However, problems such as traffic jam and bad infrastructure remain unsolved; with community behaviour as one of its root. Therefore, transportation problems ought to be resolved through socio-cultural approach besides physical improvement. Undang-Undang Lalu Lintas dan Angkutan Jalan 1992 memandang transportasi sebagai alat yang penting dan strategis untuk mendorong perkembangan ekonomi. Namun demikian, banyak masalah yang belum terselesaikan, seperti kemacetan dan infrastruktur yang buruk. Masalah-masalah itu berakar dari perilaku masyarakat. Dengan demikian, masalah transportasi mesti dipecahkan melalui pendekatan sosial-budaya selain perbaikan fisik.
Application of Origin Rules in Kaesong Industrial Complex, North Korea
Authors: Young Kim Na 
Published: August 2023

Under the expansion of regional economic integration, a product may be assembled in more than one country, creating the problem to determine the origin of the product. This paper aims to analyze the issue to recognize products manufactured in Kaesong Industrial Complex, North Korea, as products originating from South Korea. Sebagai akibat dari berkembangnya kesatuan-kesatuan ekonomi regional, suatu produk dapat diproduksi di lebih dari satu negara. Hal ini menimbulkan masalah dalam menentukan asal negara produk tersebut. Penelitian ini bertujuan untuk mempelajari isu untuk menetapkan produk-produk dari Kompleks Industri Kaesong, Korea Utara, sebagai produk yang berasal dari Korea Selatan.
Do Shareholders Care about “Surprise” Internal Control Weakness Disclosures?
Authors: Belina Hambisa , Raghunandan K. , Rama Dasaratha V. 
Published: August 2023

SUMMARY
Prior research shows that many of the companies that disclose material weaknesses in internal control (MWs) do not disclose such weaknesses in earlier quarterly 10-Q filings for the same year—i.e., the year-end MW disclosures are “surprise” disclosures. We find that shareholders at accelerated filers with surprise MW disclosures are more likely to vote against auditor ratification (by a factor of about 1.4 times) than at companies with “no-surprise” MW disclosures. These findings suggest that shareholders may at least partly blame auditors and hold them responsible for the surprise MW disclosures. Internal control disclosures necessarily involve professional judgment, but the results indicate that for shareholders, earlier disclosure of such problems is preferable to waiting until the year-end (and perhaps hoping that the problems will be resolved).
Tax Boycotts
Authors: Asay H. Scott , Hoopes Jeffrey L. , Thornock Jacob R. , Wilde Jaron H. 
Published: August 2023

ABSTRACT
To what extent do U.S. consumers change their purchase behavior or, in the extreme, boycott companies based on negative information about corporate tax activities? Practitioner publications and academic research identify consumers as a key corporate tax stakeholder. But we have limited empirical evidence whether information about corporate tax activities influences consumer actions. We undertake a comprehensive study of this question, triangulating across several settings. First, a representative sample of consumers suggests they rarely boycott in response to corporate tax activities. Next, an analysis of granular retail scanner data fails to provide compelling evidence of consumer purchase responses to negative tax news. An analysis of individual foot traffic at retail establishments around negative tax news again fails to suggest U.S. consumers change their shopping activities in response to negative tax news. The combined evidence suggests consumers do not meaningfully alter their purchase behavior in response to negative tax news.
JEL Classifications: M41; M48; H25; H26.
The impact of the COVID-19 pandemic on head and neck cancer diagnosis: a single-center study
Authors: Turski Marcin , Dorobisz Karolina , Pazdro-Zastawny Katarzyna , Zatoński Tomasz 
Published: August 2023

Abstract

Introduction
The COVID-19 pandemic has changed healthcare systems’ functioning and priorities worldwide, negatively impacting cancer screening. Adverse effects of delayed diagnosis of head and neck cancer (HNC) may be associated with poorer overall survival. The aim of the study was to assess the impact of the COVID-19 pandemic on HNC diagnosis.

Materials and Methods
A retrospective analysis of database records of patients diagnosed with HNC in a single tertiary center from March 1, 2020, until April 30, 2021 (COVID group) was performed and compared to the period from January 1, 2019, to February 30, 2020 (pre-COVID group). Patients’ general characteristics, disease extent in TNM classification, symptom duration, incidence of dyspnea at admission, emergency tracheotomy at admission, and indications for percutaneous endoscopic gastrostomy (PEG) were compared.

Results
One hundred and seventy-two patients with newly diagnosed HNC were enrolled. The most common tumor location was the larynx, followed by the hypopharynx. There were no significant differences between the groups in terms of the patients’ general or clinical characteristics, disease extent in TNM classification, and symptoms duration. However, the likelihood of PEG being performed in the COVID group was over three times higher (OR=3.15, 95% CI: 1.08 to 9.18, p=0.049).

Conclusions
During the pandemic, more patients had dysphagia or malnutrition requiring PEG. However, the pandemic did not affect the progression of patients’ HNC significantly.