bluuebunny/crossref_metadata_2025_split huggingface dataset:
Increased Fibrosis in White Adipose Tissue of Male and Female bGH Transgenic Mice Appears Independent of TGF-β Action
Authors: Bell Stephen , Young Jonathan A , List Edward O , Basu Reetobrata , Geitgey Delaney K , Lach Grace , Lee Kevin , Swegan Deborah , Caggiano Lydia J , Okada Shigeru , Kopchick John J , Berryman Darlene E 
Published: March 2023

AbstractFibrosis is a pathological state caused by excess deposition of extracellular matrix proteins in a tissue. Male bovine growth hormone (bGH) transgenic mice experience metabolic dysfunction with a marked decrease in lifespan and with increased fibrosis in several tissues including white adipose tissue (WAT), which is more pronounced in the subcutaneous (Sc) depot. The current study expanded on these initial findings to evaluate WAT fibrosis in female bGH mice and the role of transforming growth factor (TGF)-β in the development of WAT fibrosis. Our findings established that female bGH mice, like males, experience a depot-dependent increase in WAT fibrosis, and bGH mice of both sexes have elevated circulating levels of several markers of collagen turnover. Using various methods, TGF-β signaling was found unchanged or decreased—as opposed to an expected increase—despite the marked fibrosis in WAT of bGH mice. However, acute GH treatments in vivo, in vitro, or ex vivo did elicit a modest increase in TGF-β signaling in some experimental systems. Finally, single nucleus RNA sequencing confirmed no perturbation in TGF-β or its receptor gene expression in any WAT cell subpopulations of Sc bGH WAT; however, a striking increase in B lymphocyte infiltration in bGH WAT was observed. Overall, these data suggest that bGH WAT fibrosis is independent of the action of TGF-β and reveals an intriguing shift in immune cells in bGH WAT that should be further explored considering the increasing importance of B cell–mediated WAT fibrosis and pathology.
Insulin/IGF Axis and the Receptor for Advanced Glycation End Products: Role in Meta-inflammation and Potential in Cancer Therapy
Authors: Vella Veronica , Lappano Rosamaria , Bonavita Eduardo , Maggiolini Marcello , Clarke Robert Bryan , Belfiore Antonino , De Francesco Ernestina Marianna 
Published: March 2023

Abstract
In metabolic conditions such as obesity and diabetes, which are associated with deregulated signaling of the insulin/insulin-like growth factor system (IIGFs), inflammation plays a dominant role. In cancer, IIGFs is implicated in disease progression, particularly during obesity and diabetes; however, further mediators may act in concert with IIGFs to trigger meta-inflammation. The receptor for advanced glycation end-products (RAGE) and its ligands bridge together metabolism and inflammation in obesity, diabetes, and cancer. Herein, we summarize the main mechanisms of meta-inflammation in malignancies associated with obesity and diabetes; we provide our readers with the most recent understanding and conceptual advances on the role of RAGE at the crossroad between impaired metabolism and inflammation, toward disease aggressiveness. We inform on the potential hubs of cross-communications driven by aberrant RAGE axis and dysfunctional IIGFs in the tumor microenvironment. Furthermore, we offer a rationalized view on the opportunity to terminate meta-inflammation via targeting RAGE pathway, and on the possibility to shut its molecular connections with IIGFs, toward a better control of diabetes- and obesity-associated cancers.
Senyawa Bioaktif dan Antioksidan Buah Mangrove Sonneratia alba J.E. Smith dari Desa Lhok Bubon Kecamatan Samatoga Kabupaten Aceh Barat
Authors: Nufus Hayatun , Gazali Mohamad , Alaudin Alaudin , Mursawal Asri , Wahyuni Sri , ‘Akla Cut M.N. , Syahrial Syahrial , Marlian Neneng 
Published: March 2023

The mangrove species Sonneratia alba is one of the plants that has good bioactive compounds and very easy to find. However, the content of bioactive compounds and nutrients from a plant is strongly influenced by internal and external factors. The study was conducted with the aim to know the proximate content, yield and antioxidant activity of S. alba fruit from Lhok Bubon Village, Samatoga District, West Aceh Regency. The extraction method used methanol, ethyl acetate and n-hexane as solvent with antioxidant test using DPPH solution (2,2-Diphenil-2-picryl hydrazil). The results of the study showed the proximate content consisted of water 30.71%, ash 5.06%, fat 8.59%, protein 3.48% and carbohydrate 52.16%. Meanwhile, the yield showed ethyl acetate solvent had the highest yield (69.11 ± 13.27%), then followed by n-hexane (68.38 ± 13.21%) and methanol (64.44 ± 14.78%). Furthermore, for the antioxidant activity of S. alba fruit from Lhok Bubon Village, Samatoga District, West Aceh Regency, overall it was classified as very strong IC50 < 50 ppm). Spesies mangrove Sonneratia alba merupakan salah satu tanaman yang memiliki senyawa bioaktif yang baik dan sangat mudah ditemukan. Namun kandungan senyawa bioaktif dan nutrisi dari suatu tanaman sangat dipengaruhi oleh faktor internal dan eksternalnya. Penelitian dilakukan dengan tujuan untuk mengetahui kandungan proksimat, rendemen dan aktivitas antioksidan buah S. alba dari Desa Lhok Bubon Kecamatan Samatoga Kabupaten Aceh Barat. Metode ekstraksinya menggunakan pelarut methanol, etil asetat dan n-heksana dengan uji antioksidannya menggunakan larutan DPPH (2,2-Diphenil-2-picryl hydrazil). Hasil penelitian mendapatkan bahwa kandungan proksimatnya terdiri dari kadar air 30.71%, kadar abu 5.06%, kadar lemak 8.59%, kadar protein 3.48% dan kadar karbohidrat 52.16%. Sementara untuk rendemen menunjukkan bahwa pelarut etil asetat memiliki rendemen tertingginya (69.11 ± 13.27%), kemudian diikuti oleh n-heksana (68.38 ± 13.21%) dan methanol (64.44 ± 14.78%). Selanjutnya untuk aktivitas antioksidan buah S. alba dari Desa Lhok Bubon Kecamatan Samatoga Kabupaten Aceh Barat secara keseluruhannya tergolong sangat kuat (IC50 < 50 ppm).
Chloroform Fraction from Methanol Extract of Starfish Acanthaster planci Stimulates Catfish (Clarias sp.) Macrophage Immunomodulatory Activity
Authors: Achmad Janib , Yudiati Ervia , Azhar Nuril , Alghazeer Rabia 
Published: March 2023

Catfish (Clarias sp.) is Indonesia's most important and popular freshwater commodity, widely cultured and intensively grown. This study is aimed to find out the effects of the chloroform fraction from a methanol extract of Acanthaster planci on non-specific immunity in Clarias sp. Thin Layer Chromatography analysis of the methanol extract's chloroform fraction yielded three fractions: FrKl3.1, FrKl3.2, and FrKl3.3. The FrKl3.3 fraction of Acanthaster planci had a significant influence on Phagocytic Activity at doses of 0.1 (54.09 ± 8.99 %), 0.3 (48.16 ± 3.34 %), 0.5 (50.39 ± 5.71 %), and 0.7 mg/kg Body Weight (46.58 ± 0.37 %). At 0.5 mg/kg Body Weight (4.03 ± 1.40 %), the Phagocytic Index of FrKl3.2 was significantly higher than the control. At 0.5 mg/kg Body Weight (38.22 ±1.43 cell 106/ml) and 0.7 mg/kg BW (40.41 ± 1.92 cell 106/ml), the number of leukocytes/white blood cells was significantly higher than the control. Nitroblue Tetrazolium and Total Plasma Protein were not significantly different from the control. Based on the results, the FrKl3.3 was leading on phagocytic capacity and number of leukocytes
Identifikasi Spesies Pendukung Perikanan Kembung dengan Alat Tangkap Purse Seine di Perairan Utara Probolinggo, Jawa Timur
Authors: Wiadnya Dewa Gede Raka , Rahman Muhammad Arif , Harlyan Ledhyane Ika , Nurfadillah Andi Khofifah 
Published: March 2023

Short mackerel is one of small pelagic species which is prioritized in fisheries management of East Java. The first steps to improve this fishery is to carry out stock assessment, the impact of fisheries on the environment, and effective management. This study aims to identify and categorize the species supporting the mackerel fishery in Fisheries Management Area (FMA) 712, especially those caught by purse seine vessels in IPPP Paiton, Probolinggo. This study found that there were two species of short mackerel, Rastrelliger branchysoma and R. kanagurta. There were 16 species interacting with this fishery, none of them were included in the Endangered, Threatened, and Protected (ETP) category based on the IUCN Redlist. These species are categorized into 2 groups, namely main secondary (5 species) and minor secondary (11 species), with the largest proportion being was goldstipe sardine. This information can be a start in the fisheries improvement program of short mackerel fishery in East Java. Future research related to the stocks, habitats and ecosystems of each species can be carried out to complete the information and support the formulation as well as implementation of fisheries improvement program of short mackerel fishery in East Java. Ikan kembung merupakan salah satu jenis pelagis kecil yang menjadi prioritas dalam pengelolaan perikanan di Jawa Timur. Salah satu langkah awal untuk melakukan perbaikan perikanan ini adalah dengan melakukan penilaian terkait stok, dampak perikanan terhadap lingkungan, serta tata kelola atau pengelolaan yang efektif. Penelitian ini bertujuan untuk mengidentifikasi dan mengkategorisasi spesies pendukung perikanan kembung pada Wilayah Pengelolaan Perikanan (WPP) 712, khususnya yang ditangkap oleh kapal-kapal purse seine dari IPPP Paiton, Probolinggo. Hasil penelitian mendapatkan bahwa ikan kembung yang tertangkap terdiri dari kembung perempuan (R. branchysoma) dan kembung lelaki (R. kanagurta). Spesies pendukung atau yang berinteraksi dengan perikanan ini ditemukan sebanyak 16 spesies, dengan tidak ada spesies yang masuk dalam kategori Endangered, Threatened, and Protected (ETP) berdasarkan Redlist IUCN. Spesies pendukung ini dikategorikan kedalam 2 kelompok, yaitu sekunder utama (5 spesies) dan sekunder minor (11 spesies), dengan proporsi terbesar adalah ikan tembang. Informasi ini dapat menjadi awal dalam proses perbaikan perikanan kembung di Jawa Timur. Penelitian lain terkait stok, habitat, dan ekosistem masing-masing spesies dapat dilakukan untuk melengkapi informasi dalam mendukung rumusan dan pelaksanaan program perbaikan perikanan kembung di Jawa Timur.
Degradasi Karbohidrat pada Pakan Udang oleh Isolat Kapang Endofit Mangrove
Authors: Artono Sri Lintang , Trianto Agus , Jaya Nur Taufiq Syamsudin Putra Jaya Taufiq Syamsudin Putra , Sabdono Agus , Subagiyo Subagiyo , Pringgenies Delianis , Pringgenies Delianis , Djamaludin Rignolda , Tjoa Aiyen 
Published: March 2023

Feed quality is a very important factor in shrimp farming because it will affect shrimp growth, water quality and even the emergence of pathogenic bacteria. High quality feed can be well digested by shrimp so that it can improve the growth and do not leave plenty of residue. Mold is capable of producing cellulase which can be used to improve feed quality by shortening carbohydrate chains. This paper will discuss the application of endophytic molds to simplify cellulose in shrimp feed. Mold isolates were collected from mangrove ecosystems in North Sulawesi. The media used for culturing mold are potato dextrose agar (PDA) and potato dextrose broth (PDB). Fermentation test was conducted using the fungal isolates; Hypocreales sp. and Diaporthe stewartii and consortia and controls. Fermentation results were checked by TLC and Fehling's test to determine the composition of the compounds and the presence of reducing sugar either mono or di-saccharide. Fermented shrimp feed shows differences in texture and color. Fermented feed extract with Hypocreales sp. 2.69 g (3.36%), Diaporthe stewartii 4.9 g (6.13%), and consortium 3.75 g (4.69%). TLC results neither under UV light nor visualization of vanillin sulfate did not show any differences of compounds in the control and the fermented feed. The results of the Fehling test showed that the mold was able to degrade cellulose that can be utilized to increase the shirmp feed quality. Kualitas pakan merupakan faktor yang sangat berpengaruh dalam budidaya udang karena akan mempengaruhi pertyumbuhan udang, kualitas air bahkan timbulnya bakteri pathogen. Pakan yang baik mudah dicerna oleh udang sehingga dapat meningkatkan pertumbuhan secara maksimal dan tidak terlalu banyak meninggalkan residu. Kapang mampu memproduksi selulase yang dapat digunakan untuk meningkatkan kualitas pakan dengan memperpendek rantai karbohidrat. Tulisan ini akan membahas aplikasi kapang endofit untuk menyederhanakan selulosa pada pakan udang. Isolat kapang dikoleksi dari ekosistem mangrove di Sulaweri Utara. Media yang digunakan untuk mengkultur kapang adalah potato dextrose agar (PDA) dan potato dextrose broth (PDB). Uji fermentasi dengan kapang Hypocreales sp. dan Diaporthe stewartii dan konsorsium serta kontrol. Hasil fermentasi dicek dengan TLC dan uji Fehling untuk mengetahui komposisi senyawa dan keberadaan mono-karbohidrat. Pakan udang yang difermentasi menunjukkan perbedaan tekstur dan warna. Ekstrak pakan fermentasi dengan Hypocreales sp. sebesar 2,69 g (3,36%), Diaporthe stewartii sebesar 4,9 g (6,13%), dan konsorsium sebesar 3,75 g (4,69%). Hasil TLC dan visualisasi vanillin sulfat tidak menunjukkan perbedaan jenis senyawa pada pakan kontrol dan pakan terfermentasi. Hasil uji Fehling menunjukkan bahwa kapang mampu mendegradasi selulosa yang dapat digunakan untuk meningkatkan kualitas pakan udang.
Konsentrasi Logam Berat Timbal (Pb) dan Tembaga (Cu) pada Hasil Tangkapan Nelayan Pesisir Semarang dan Tegal Jawa Tengah
Authors: Suryono Chrisna Adhi , Indardjo Agus 
Published: March 2023

Coastal areas of Semarang and Tegal are the fishing ground area of traditional fishermen. But with the increasing activity in coastal and marine areas it will increase heavy metal contaminants in these waters which are allegedly contaminating existing biota. Heavy metals are pollutants that can accumulate in marine life. This study aims to know the concentration of lead metals (Pb) and copper (Cu) on the catch of the coastal fishermen of Semarang and Tegal, Central Java. Analysis of Pb and Cu concentration in tissue organisms using ICPMS. The results of the analysis showed that Pb and Cu metals were found in biota such as white shrimp (P. merguensis), crab (P. pelagicus), coocle (A. inaequivalvalvis) and gastropods (H. ternatanus). The highest concentration of Pb in the four biota captured in Semarang (4.48-5.76 ppm) and Tegal (0.53-3,055 ppm). Whereas the highest Cu metal in the biota argued in the Tegal waters (0.16 - 0.197ppm) while in Semarang (0.03-0.177 ppm) Semarang. The highest concentration of Pb (3,055-5.58 ppm) is found in gastropods both in Semarang and Tegal. Thus, the metal Cu (0.177-0.197 ppm) in gastropods from Tegal and Semarang. Gastropods accumulate the highest Pb and Cu metal in the two regions of the fishing ground. Pesisir Semarang dan Tegal merupakan daerah fishing ground nelayan tradisional. Namun dengan semakin meningkatnya aktifitas di wilayah pesisir dan laut tersebut akan meningkatkan kontaminan logam berat di perairan tersebut yang diduga akan mengkontaminasi biota yang ada. Logam berat merupakan polutan yang dapat terakumulasi dalam biota laut. Penelitian ini bertujuan untuk mengetahui konsentrasi logam Timbal (Pb) dan Tembaga (Cu) pada Hasil Tangkapan Nelayan Pesisir Semarang dan Tegal Jawa Tengah. Analisa konsentrasi Pb dan Cu dalam jaringan organisme menguunakan ICPMS. Hasil analisa menunjukkan logam Pb dan Cu ditemukan dalam biota seperti udang putih (P. Merguensis), rajungan (P. pelagicus), kerang bulu (A. inaequivalvis) dan gastropoda (H. ternatanus). Konsentrasi tertinggi Pb di keempat biota yang ditangkap di Semarang (4,48–5,76 ppm) dan Tegal (0,53– 3,055 ppm). Sedangkan logam Cu tertinggi pada biota yang ditangkap di perairan Tegal (0.16– 0.197ppm) sedangkan di Semarang (0.03–0.177 ppm) Semarang. Konsentrasi tertinggi Pb (3,055–5,58 ppm) terdapat dalam gastropoda baik di Semarang maupun Tegal. Demikian logam Cu tertingggi (0,177 - 0,197 ppm) pada gastropoda dari Tegal dan Semarang. Gastropoda mengakumulasi logam Pb dan Cu tertinggi di kedua daerah fishing ground tersebut.
Profound hyponatremia and dehydration: A case of cisplatin induced renal salt wasting syndrome
Authors: George Tissa Bijoy , Kuriakose Kiran , Pillai Anjana Chandrasekhara , Powell Thomas , Kleyman Thomas R. 
Published: March 2023

AbstractCisplatin is a well‐known chemotherapeutic agent that can be associated with hyponatremia. It is known to be associated with a multitude of renal disorders including acute kidney injury with reduced glomerular filtration, Fanconi syndrome, and renal tubular acidosis, nephrogenic diabetes insipidus and renal salt wasting syndrome. We report a case of an elderly male presenting with significant recurrent hyponatremia, and prerenal azotemia. With recent exposure to cisplatin along with significant hypovolemia and urinary loss of sodium, he was diagnosed to have cisplatin induced renal salt wasting syndrome.
Mechanical properties, elastic moduli, and gamma ray attenuation competencies of some TeO2–WO3–GdF3 glasses: Tailoring WO3–GdF3 substitution toward optimum behavioral state range
Authors: ALMisned Ghada , Rabaa Elaf , Sen Baykal Duygu , Kavaz Esra , Ilik Erkan , Kilic Gokhan , Zakaly Hesham M. H. , Ene Antoaneta , Tekin Huseyin Ozan 
Published: March 2023

Abstract
We report the mechanical properties, elastic moduli, and gamma ray attenuation properties of some TeO2–WO3–GdF3 glasses. Using the chemical composition of the selected glasses, the dissociation energy per unit volume (G

t
) and the packing density (V

t
) were calculated. Using the G

t
and V

t
values, Young’s, Shear, Bulk, Longitudinal Modulus, and Poisson’s ratio of the glasses are calculated. Next several fundamental gamma ray attenuation properties such as linear and mass attenuation coefficients, half value layer, mean free path, effective atomic number, effective electron density, effective conductivity, exposure, and energy absorption buildup factors are calculated in 0.015–15 MeV energy range. As a consequence of WO3–GdF3 substitution, the glass densities are observed in different values. The overall gamma ray attenuation properties are found to be enhanced through WO3 addition. Moreover, the increasing WO3 incorporation into glass configuration decreases the overall elastic moduli of glasses. It can be concluded that increasing WO3 may be a useful tool for enhancing the gamma ray attenuation qualities and decreasing the elastic moduli of TeO2–WO3–GdF3 in situations where a material with versatile mechanical properties is required.
Evaluation of dynamic behavior of varved clays from the Warsaw ice-dammed lake, Poland
Authors: Nielepkowicz Krzysztof , Dobak Paweł , Bąkowska Anna 
Published: March 2023

Abstract
Soil stiffness degradation due to dynamic loading may result in damage to engineering structures. Therefore, dynamic soil properties gained importance in recent years in the areas where vibrations of different origins are transmitted to the ground. The aim of the study was to determine the stiffness properties of the Warsaw varved clay (central Poland), as a measure of its response to dynamic loading. A set of triaxial tests were conducted. Undisturbed samples were subjected to initial deviator stress of 100 kPa, reflecting vertical stress due to construction load, and then to three dynamic stages under axial displacement control conditions. Secant shear modulus G was adopted as a parameter of soil stiffness during dynamic loading. Main methodological result of the study is application of coefficient α (gradient of logarithmic change in stiffness with time) indicating type of soil behavior under dynamic loading. Negative α values (ranging from −0.48 to −0.91) indicated a weakening effect of the applied vibrations (decrease in stiffness), while positive α values (ranging from 0.11 to 0.21) indicated soil strengthening (increase in stiffness). Results of the study may be applied to compare an impact of several factors influencing soil stiffness during dynamic loading
Effect of four-week home-based exercise program on immune response, fat and muscle mass in subjects recovered from COVID-19
Authors: Ghasemi Peyman , Shirvani Hossein , Shamsoddini Alireza 
Published: March 2023

AbstractObjectivesA rehabilitation program for patients with COVID-19 may be required to improve related side effects. This study aimed to investigate the effect of a four-week home workout on body composition and serum levels of IL-6 and cortisol in men recovering from COVID-19.MethodsThe present study is quasi-experimental. To this end, 45 healthy individuals in Tehran were purposefully divided into three groups: those who recovered after COVID-19 (n=30), including two groups of exercise and non-exercise, and individuals who did not have COVID-19 (control) (15=n). The four-week training program included three days of training per week with Traband resistance stretches, weight body training, and cardio exercises. The smirnov-Kolmogorov test was employed for data normality. A one-way analysis of variance test will be used to compare both the mean of variables in groups and the mean of variables before and after the exercise, correlated t-test was employed at a significance level of 0.05.ResultsThe results showed that serum levels of interleukin 6 and cortisol were significantly reduced in the recovered training group (p=0.001) and the non-trained recovery group (p=0.001) and a significant difference was observed between the groups (p=0.001). Furthermore, only in the recovered training group, did the fat percentage (p=0.001) and muscle mass (p=0.001) respectively decreased and increased.ConclusionsFour-week home training improves body composition by reducing body fat percentage and increasing muscle mass. In addition, lowering interleukin-6 and cortisol leads to reduced inflammation, faster recovery, and increased immunity.
The crystal structure of 2-bromo-1,3-phenylene bis(4-methylbenzenesulfonate), C20H17BrO6S2
Authors: Chen Jue-Yuan , Zou Long-Sheng , Lai Ni , Yin Zi-Yi , Yuan Lin , Li Zhong-Yan 
Published: March 2023

Abstract
C20H17BrO6S2, triclinic,

P

1
‾

$P\overline{1}$

(no. 2), a = 8.173(2) Å, b = 8.256(2) Å, c = 16.514(5) Å, α = 89.947(3)°, β = 83.105(3)°, γ = 72.077(3)°, V = 1051.8(5) Å3, Z = 2, Rgt
(F) = 0.0334, wRref
(F
2) = 0.0889, T = 296(2) K.