bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chemical Strategies Toward Prodrugs and Fluorescent Probes for
Gasotransmitters
Authors: Su Ma , Ji Xingyue , Liu Feng , Li Zhang , Yan Duanyang 
Published: April 2023

Abstract:
Three gaseous molecules are widely accepted as important gasotransmitters in mammalian
cells, namely NO, CO and H2S. Due to the pharmacological effects observed in preclinical studies,
these three gasotransmitters represent promising drug candidates for clinical translation. Fluorescent
probes of the gasotransmitters are also in high demand; however, the mechanisms of actions
or the roles played by gasotransmitters under both physiological and pathological conditions remain
to be answered. In order to bring these challenges to the attention of both chemists and biologists
working in this field, we herein summarize the chemical strategies used for the design of both
probes and prodrugs of these three gasotransmitters.
Traditional Chinese Medicine Targeting Sarcoma Virus Oncogene-related Diseases
Authors: Wang Yiying , Wang Xiaoyu , Su Kexin , Yang Yifu 
Published: April 2023

Abstract:The sarcoma virus oncogene (Src) tyrosine kinase, a nonreceptor protein-tyrosine kinase, plays a crucial role in cell survival, migration, differentiation and proliferation. The study of Src has developed considerably since it was first discovered as a proto-oncogene. Src has also been associated with inflammation and bone-related diseases. Src inhibitors (bosutinib, ponatinib, dasatinib, and vandetanib) have been put into clinical use. However, their side effects and cardiovascular toxicity may be a concern. There is an urgent need to explore new Src inhibitors. Traditional Chinese medicine (TCM), which has a vast history, can provide a broad resource base. Many natural compounds and TCM extracts have the potential for anti-Src treatment. This article describes the natural compounds and extracts from TCM.
Current Trends and Future Prospects on the Therapeutic Potential of Cordia dichotoma G. Forst.-A Valuable Folk Medicine
Authors: Tripathi Rati Kailash Prasad 
Published: April 2023

Background:
Cordia dichotoma G. Forst (Boraginaceae), usually recognized as Clam-my/Indian cherry, is a familiar Ayurvedic, Unani, and modern herbal medicine used for diverse un-related ailments since antiquity. It is rich in phytochemical constituents, has nutritional significance, and possesses enormous pharmacological properties.

Objective:
This review has been established to highlight the importance of C. dichotoma G. Forst by providing comprehensive knowledge of its phytochemical, ethnobotanical, pharmacological, and toxicological aspects with a perception to foster pharmaceutical research to exploit its maximum po-tential as a therapeutic agent.

Methods:
Literature research has been accomplished using Google Scholar and databases like Sci-ence Direct, WOS, PubMed, SciFinder, Scopus with updates until June 2022.

Results:
The work is an update on C. dichotoma G. and it reviewed and analyzed its phytochemical, ethnobotanical, pharmacological and toxicological knowledge from early human communities to contemporary medicinal and pharmaceutical applications with comprehensive examination of myri-ad plausible applications in the present-day scientific milieu. The species depicted the presence of diverse phytochemical profiles, possibly justifying its bioactive potential.

Conclusion:
This review will help lay grounds to facilitate state-of-art research intended to acquire additional information about the plant. The study offers opportunities to explore bio-guided isola-tion strategies for isolating and purifying phytochemical constituents that are biologically effective including pharmacological and pharmaceutical aspects to better understand its clinical relevance. Exploring pure isolated phytoconstituents for their mode of action including estimation of their bio-availability and pharmacokinetic parameters would be of considerable interest in assessing the at-tained pharmacological effect. Clinical studies are required to validate the suitability of its tradition-al usage.
A Quinquennial Review on Recent Advancements and Developments in
Search of Anti-malarial Agents
Authors: Dhameliya Tejas M. , Kathuria Deepika , Patel Tanvi M. , Dave Bhavarth P. , Chaudhari Amit Z. , Vekariya Drashtiben D. 
Published: April 2023

Abstract:
Malaria has been a major parasitic disease in tropical and subtropical regions and is esti-mated to kill between one and two million people (mainly children) every year. Novel anti-malarial agents are urgently needed to combat the malarial parasites enduring resistance to the current medi-cations, leading to increased morbidity and mortality. The heterocycles, holding a prominent posi-tion in chemistry and found in both natural and synthetic sources, have shown several biological ac-tivities including anti-malarial activity. Towards this goal, several research groups have reported the design and development of novel and potential anti-malarial agents like artemisinin, benzimidazole, benzothiazole, chalcone, cyclopeptide, fosmidomycin, furan, indole oxadiazole, 2-oxindoles, perox-ides, pyrazole, pyrazolines, pyridines, pyrimidine, pyrrolidine, quinazoline, quinazolinone, quino-lone, quinoline, thiazole, triazole and other scaffolds acting against newly emerging anti-malarial targets. The present work reports the complete quinquennial coverage of anti-malarial agents re-ported during 2016-2020 with a view of providing the merits and demerits of reported anti-malarial scaffolds, structure-activity relationship, along with their in vitro/ in vivo/ in silico profiles to the medicinal chemists working in the field of design and discovery of novel anti-malarial agents
Advances in Imaging Techniques of the Blood-brain Barrier and Clinical
Application
Authors: Cui Jianing , Bian Wenjin , Wang Jun , Niu Jinliang 
Published: May 2023

Abstract:
The blood-brain barrier (BBB) is an important structure that maintains the normal function of the central nervous system (CNS). The functional
structure of BBB is closely related to diseases of CNS, including degenerative diseases, brain tumours, traumatic brain injury, stroke, etc. Imaging
methods were commonly used to monitor the integrity of BBB, such as DCE-MRI, DSC-MRI, and PET, this contributes to understand the process
of related diseases and develop appropriate treatment options. In recent years, many studies had shown that the MRI methods (ASL, IVIM, CEST,
etc.) could evaluate blood-brain barrier function, which use endogenous contrast agents and become an increasingly great concern. Another image
methods (FUS, uWB-eMPs) can open up the normal BBB, allowing macromolecular drugs across the locally opening BBB, which could be
beneficial to the treatment of some brain diseases. In this review, we briefly introduce the theory of BBB imaging modalities and its clinical
application.
Research Progress on the Effect of Autophagy and Exosomes on Liver
Fibrosis
Authors: Du Yikuan , Zhu Silin , Zeng Haojie , Wang Zhenjie , Huang Yixing , Zhou Yuqi , Zhang Weichui , Zhu Jinfeng , Yang Chun 
Published: April 2023

Abstract:
Chronic liver disease is a known risk factor for the development of liver cancer, and the development
of microRNA (miRNA) liver therapies has been hampered by the difficulty of delivering miRNA
to damaged tissues. In recent years, numerous studies have shown that hepatic stellate cell (HSC) autophagy
and exosomes play an important role in maintaining liver homeostasis and ameliorating liver fibrosis.
In addition, the interaction between HSC autophagy and exosomes also affects the progression of liver
fibrosis. In this paper, we review the research progress of mesenchymal stem cell-derived exosomes
(MSC-EVs) loaded with specific miRNA and autophagy, and their related signaling pathways in liver
fibrosis, which will provide a more reliable basis for the use of MSC-EVs for therapeutic delivery of
miRNAs targeting the chronic liver disease.
LncRNA FAM83H-AS1 Contributes to the Radio-resistance and Proliferation
in Liver Cancer through Stability FAM83H Protein
Authors: Jiang Xiaocong , Lan Yuhong , Zhang Yingchun , Dong Yuhong , Song Ting 
Published: May 2023

Background:
Liver cancer (LC) is one of China's most common malignant tumors,
with a high mortality rate, ranking third leading cause of death after gastric and esophageal cancer.
Recent patents propose the LncRNA FAM83H-AS1 has been verified to perform a crucial role in
the progression of LC. LncRNA FAM83H-AS1 has been verified to perform a crucial role in the
progression of LC. However, the concrete mechanism remains to be pending further investigation

Objective:
This study aimed to explore the embedding mechanism of FAM83H-AS1 molecules in
terms of radio sensitivity of LC and provide potentially effective therapeutic targets for LC therapy.

Methods:
Quantitative real-time PCR (qRT-PCR) was conducted to measure the transcription levels
of genes. Proliferation was determined via CCK8 and colony formation assays. Western blot was
carried out to detect the relative protein expression. A xenograft mouse model was constructed to
investigate the effect of LncRNA FAM83H-AS1 on tumor growth and radio-sensitivity in vivo.

Results:
The levels of lncRNA FAM83H-AS1 were remarkably increased in LC. Knockdown of
FAM83H-AS1 inhibited LC cell proliferation and colony survival fraction. Deletion of FAM83H-AS1
increased the sensitivity of LC cells to 4 Gy of X-ray radiation. In the xenograft model, radiotherapy
combined with FAM83H-AS1 silencing significantly reduced tumor volume and weight. Overexpression
of FAM83H reversed the effects of FAM83H-AS1 deletion on proliferation and colony survival
fraction in LC cells. Moreover, the over-expressing of FAM83H also restored the tumor volume
and weight reduction caused by the knockdown of FAM83H-AS1 or radiation in the xenograft model.

Conclusion:
Knockdown of lncRNA FAM83H-AS1 inhibited LC growth and enhanced radiosensitivity
in LC. It has the potential to be a promising target for LC therapy.

Clinical Trial Registration No:
.: ChiCTR1800019378.
Recent Patents of Micro-arc Oxidation Technology
Authors: Yuan Mengchen , Li Zhaolong 
Published: May 2023

Abstract:
Micro-arc oxidation (MAO) is a new surface treatment technology that can improve
wear resistance, corrosion resistance, high voltage insulation, and other metal properties. Therefore,
this technology is widely used in automobile manufacturing, aerospace, ship anti-corrosion,
medical equipment, sewage treatment, and other fields. This paper reviews the representative patents
of micro-arc oxidation technology at home and abroad. The micro-arc oxidation processing
device, the process method of micro-arc oxidation processing, the power supply and electrical
parameters of micro-arc oxidation, the preparation of electrolytes, and the methods of anticorrosion
and protection of metal surface are analyzed. The development trend of micro-arc oxidation
technology in the future is discussed. Micro-arc oxidation is a simple, green, and environment-
friendly surface treatment technology, and there will be more patents in the field of micro-
arc oxidation in the future.
Tendensi Wakaf Uang di LWPNU-PWNU YOGYAKARTA
Authors: Ismiati Baiq , Sani Ageng Asmara , Diniyah Umi Saniatun 
Published: May 2023

Latar belakang dari penelitian ini adalah permasalahan wakaf uang sebagai salah satu instrumen penggalangan dana masyarakat untuk kepentingan kesejahteraan umat. Instrumen ini belum digarap secara maksimal, baik dari sisi penghimpunan maupun pengelolaannya hal ini berbanding terbalik dengan potensi wakaf yang sangat besar.<p>Penelitian ini dilakukan di LWPNU-PWNU Yogyakarta. Jenis penelitian menggunakan lapangan (<em>field research</em>). Penelitian ini bersifat kualitatif deskriptif (<em>qualitative descriptive research</em>). Teknik pengumpulan data yang digunakan adalah observasi, wawancara dan dokumentasi. Adapun analisis data yang digunakan analisis data model Miles and Huberman dengan langkah- langkah <em>data collection, data condensa, data display, </em>dan <em>conclusions drawing/verifysing.</em></p><p>Berdasarkan hasil analisis yang telah diuraikan tentang “Tendensi Wakaf Uang di LWPNU-PWNU Yogyakarta (Antara Produktif Dan Konsumtif), maka dapat dirumuskan; <em>pertama</em>, lembaga pengelola wakaf tunai oleh LWPNU- PWNU Yogyakarta lebih memberikan pemahaman masyarakat manfaat adanya wakaf uang dan masyarakat melakukan pewakafan di lembaga. <em>Kedua</em>, Mekanisme pengelolaan Wakaf Uang di LWPNU-PWNU Yogyakarta dilaksanakan menurut UU wakaf dan peraturan pelaksanaanya diantaranya: <em>Pertama</em>, Proses penghimpunan, yang mana hal ini dilakukan oleh LWPNU- PWNU Yogyakarta dengan sistem bantingan dilakukan melalui kotak wakaf dan sebagainya. <em>Kedua</em>, mekanisme LWPNU-PWNU Yogyakarta dalam pengelolaan wakaf uang terdiri dari penghimpunan, sosialisasi, dan penyaluran dana 3) Implikasi pengelolaan wakaf uang di LWPNU-PWNU Yogyakarta terlihat pada tiga hal yakni: bidang sarana ibadah, bidang pendidika, dan bidang ekonomi.</p><p><strong>K</strong><strong>ata kunci</strong>: Wakaf, Pengelolaan Wakaf Uang dan LWPNU-PWNU Yogyakarta.<strong></strong></p>
The Influence of Age, Sex, and Socioeconomic Status on Glycemic Control Among People With Type 1 and Type 2 Diabetes in Canada: Patient-Led Longitudinal Retrospective Cross-sectional Study With Multiple Time Points of Measurement
Authors: Mousavi Seyedmostafa , Tannenbaum Greenberg Dana , Ndjaboué Ruth , Greiver Michelle , Drescher Olivia , Chipenda Dansokho Selma , Boutin Denis , Chouinard Jean-Marc , Dostie Sylvie , Fenton Robert , Greenberg Marley , McGavock Jonathan , Najam Adhiyat , Rekik Monia , Weisz Tom , Willison Donald J , Durand Audrey , Witteman Holly O ,   Diabetes Action Canada Research Questions Prioritization Study
Published: April 2023

Background
Clinical guidelines for most adults with diabetes recommend maintaining hemoglobin A1c (HbA1c) levels ≤7% (≤53 mmol/mol) to avoid microvascular and macrovascular complications. People with diabetes of different ages, sexes, and socioeconomic statuses may differ in their ease of attaining this goal.

Objective
As a team of people with diabetes, researchers, and health professionals, we aimed to explore patterns in HbA1c results among people with type 1 or type 2 diabetes in Canada. Our research question was identified by people living with diabetes.

Methods
In this patient-led retrospective cross-sectional study with multiple time points of measurement, we used generalized estimating equations to analyze the associations of age, sex, and socioeconomic status with 947,543 HbA1c results collected from 2010 to 2019 among 90,770 people living with type 1 or type 2 diabetes in Canada and housed in the Canadian National Diabetes Repository. People living with diabetes reviewed and interpreted the results.

Results
HbA1c results ≤7.0% represented 30.5% (male people living with type 1 diabetes), 21% (female people living with type 1 diabetes), 55% (male people living with type 2 diabetes) and 59% (female people living with type 2 diabetes) of results in each subcategory. We observed higher HbA1c values during adolescence, and for people living with type 2 diabetes, among people living in lower income areas. Among those with type 1 diabetes, female people tended to have lower HbA1c levels than male people during childbearing years but higher HbA1c levels than male people during menopausal years. Team members living with diabetes confirmed that the patterns we observed reflected their own life courses and suggested that these results be communicated to health professionals and other stakeholders to improve the treatment for people living with diabetes.

Conclusions
A substantial proportion of people with diabetes in Canada may need additional support to reach or maintain the guideline-recommended glycemic control goals. Blood sugar management goals may be particularly challenging for people going through adolescence or menopause or those living with fewer financial resources. Health professionals should be aware of the challenging nature of glycemic management, and policy makers in Canada should provide more support for people with diabetes to live healthy lives.
A Tailored mHealth App for Improving Health and Well-Being Behavioral Transformation in UK Police Workers: Usability Testing via a Mixed Methods Study
Authors: Mehra Richa , Pulman Andy , Dogan Huseyin , Murphy Jane , Bitters Fiona 
Published: May 2023

Background
When considering the policing environment of 2022, many roles previously in the domain of warranted officers (police officer) are now performed by nonwarranted police staff equivalents. These police staff roles have expanded rapidly into other areas such as investigations, custody, and contact management, which were traditionally seen as police officer functions and put staff under some of the same stresses as police officers. A UK police force requested help in investigating technologies that could be used to improve health and well-being for both officers and staff.

Objective
The aim of this study was to create a health and well-being app for police officers and staff, which considered the unique requirements of the users throughout the designing, building, prototyping, and testing stages.

Methods
This study involved quantitative approaches (demographic web-based survey questions and the System Usability Scale) and qualitative approaches (open web-based survey questions and semistructured interviews). Unsupervised usability testing of a prototype app was undertaken by members (N=48) of the commissioning client using their smartphones. After completing a preregistration application for screening purposes, participants downloaded a trial version of the app. Then, they completed a web-based questionnaire after testing the app for 10 days. A subsample of participants (9/48, 19%) was interviewed. Deductive thematic analysis was undertaken to identify key themes and subthemes.

Results
Data collected during usability testing concerned the 6 domains of the app—food and diet, activity, fluid intake, sleep, good mental health, and financial well-being—and informed the creation of improved design during prototyping. Some usability and design issues and suggestions for improvements were also addressed and implemented—including shift management and catch-up cards—during this cycle of development.

Conclusions
This study highlights the importance of coparticipation with officers and staff across the entire development cycle, to coproduce a human-centered design methodology to enable the development of a considered and user-centered solution. It demonstrates the need for producing a multifunctional tool rather than focusing purely on an individual element for this user group. It also highlights how linking and being able to track optional, personalized elements of health data against one another, cross-referenced to individual shift patterns, might help to inform and provide users with a chance for reflection and therefore influence behavior change.
Evaluating Listening Performance for COVID-19 Detection by Clinicians and Machine Learning: Comparative Study
Authors: Han Jing , Montagna Marco , Grammenos Andreas , Xia Tong , Bondareva Erika , Siegele-Brown Chloë , Chauhan Jagmohan , Dang Ting , Spathis Dimitris , Floto R Andres , Cicuta Pietro , Mascolo Cecilia 
Published: May 2023

Background
To date, performance comparisons between men and machines have been carried out in many health domains. Yet machine learning (ML) models and human performance comparisons in audio-based respiratory diagnosis remain largely unexplored.

Objective
The primary objective of this study was to compare human clinicians and an ML model in predicting COVID-19 from respiratory sound recordings.

Methods
In this study, we compared human clinicians and an ML model in predicting COVID-19 from respiratory sound recordings. Prediction performance on 24 audio samples (12 tested positive) made by 36 clinicians with experience in treating COVID-19 or other respiratory illnesses was compared with predictions made by an ML model trained on 1162 samples. Each sample consisted of voice, cough, and breathing sound recordings from 1 subject, and the length of each sample was around 20 seconds. We also investigated whether combining the predictions of the model and human experts could further enhance the performance in terms of both accuracy and confidence.

Results
The ML model outperformed the clinicians, yielding a sensitivity of 0.75 and a specificity of 0.83, whereas the best performance achieved by the clinicians was 0.67 in terms of sensitivity and 0.75 in terms of specificity. Integrating the clinicians’ and the model’s predictions, however, could enhance performance further, achieving a sensitivity of 0.83 and a specificity of 0.92.

Conclusions
Our findings suggest that the clinicians and the ML model could make better clinical decisions via a cooperative approach and achieve higher confidence in audio-based respiratory diagnosis.
Minimum tillage on vertisols lowland increases rice production and soil properties
Authors: Zulhaedar Fitria , Nurudin Makruf , Hanudin Eko 
Published: April 2023

Current land management is a challenge for wetlands vertisol soil types, especially on the rice production, which often clashes with future soil quality. This study aimed to obtain optimal performance of rice growth and physical and chemical properties of vertisol soil on various tillage systems. The study was carried out in the vertisol rice fields of Batu Bolong sub-village, Ungga village, Southwest Praya District, Central Lombok Regency, West Nusa Tenggara during the second growing season (March-October) in 2021. The experimental design was arranged in a Completely Randomized Design consisting of three levels of: no-tillage as T1, minimum tillage as T2, and maximum tillage as T3, with each treatment being repeated five times. The use of production inputs and infrastructure was uniform in all experimental plots. The results showed that T2 treatment had some of the best parameters for rice growth and yield as well as the physical and chemical properties of the land. Plant height and number of tillers at T2 were significantly more maximal in observing the vegetative phase. The dry weight of 1000 grains and rice productivity from the highest were respectively T2 > T1 > T3. The physical and chemical parameters of the soil also showed the same order. Thus, it can be said that minimum tillage is the best tillage system to obtain the growth and yield of rice in the second growing season and the most optimal physical and chemical properties of vertisol soil.
Effect of deficit irrigation on the growth and yield of peanuts (Arachis hypogaea (L.) Merr.) compared to AquaCrop model simulation
Authors: Suandana Febery Hery , Bowo Cahyoadi , Soeparjono Sigit 
Published: April 2023

The availability of irrigation water during the growing season reflects on the potential yield at the end of the peanuts’ growing season. Monitoring water availability is essential to optimize production. This study aimed to identify the effect of irrigation water on peanuts (Arachis hypogaea (L.) Merr.) under various irrigation conditions between actual and simulated AquaCrop. The research was conducted in the experimental field utilizing four irrigation treatments which were 60%, 80%, 100% of field capacity (FC), and standard irrigation. The correlation results between the actual and simulated ones showed that the R2 value was 0.974–0.990 for the canopy cover parameter, 0.026–0.534 for ETc, and 0.542-0.554 for production. Comparison between actual and simulated AquaCrop showed Root Mean Square Error (RMSE) values of 5.08–­­9.74 for canopy cover parameters, 1.11–3.12 for ETc, and 0.82–1.09 for production. Welch test statistical analysis indicated values of 2.31–5.52 for plant biomass and 0.04–3.98 for dry pod yields. The AquaCrop simulation accurately predicted canopy cover at 80% irrigation treatment compared to 60%, 100%, and standard irrigation treatments. Parameter of ETc in AquaCrop simulations showed inaccurate predictions for biomass production and pod dry weight when compared with actual results on all irrigation treatments.