bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transcriptional and synaptic regulation of NMDA glutamate receptor-mediated hippocampal plasticity and memory
Authors: Parra-Damas Arnaldo , del Ser-Badia Anna , Fernandez-Olaya Xavier , Deprada-Fernandez Ángel , Enríquez-Barreto Lilian , Prius-Mengual José , Català-Solsona Judit , Brito Verónica , Rodríguez-Alvarez José , Ginés Silvia , Rodríguez-Moreno Antonio , Saura Carlos A. 
Published: January 2025

SUMMARYSynapse-to-nucleus signaling regulates activity-dependent synaptic plasticity underlying memory by linking N-methyl-D-aspartate (NMDA) glutamate receptors (GluN) to gene transcription mediated by the transcription factor cAMP-response element binding protein (CREB), but the underlying gene programs mediating potentiation at excitatory synapses are unknown. Here, we analyzed genome-wide chromatin immunoprecipitation sequencing (ChIP-seq) datasets of mouse and human CREB and the synaptonuclear factor CREB-regulated transcription coactivator1 (CRTC1) to identify relevant target genes and biological pathways coupling neuronal activity to synaptic function/plasticity. Our analyses indicate that CRTC1 specifically couples neuronal activity with synaptic plasticity by binding to conserved promoters of CREB target genes comprising inducible transcription factors (includingc-fos,Crem,Npas4andNr4a1-3), and neuronal excitability and plasticity genes, includingNtrk2,Homer1,Dlg4(PSD-95) and the NMDA receptor subunitGrin1(GluN1). CRTC1/CREB target genes were highly enriched in gene ontology (GO) nuclear terms, including several members of the CREB family, and transcriptional modulators and repressors. Interestingly, GO enrichment and protein-protein interaction (PPI) network analyses revealed that genes mediating synapse-to-nucleus signaling (including most known synaptonuclear factors and direct interacting modulators) are collectively regulated by CREB/CRTC1, and that protein kinase C (PKC) is a key interactor of the CRTC1/14-3-3 complex at synapses. In agreement with thesein silicoanalyses, we show that CRTC1 regulates synaptic activity-dependent phosphorylation and synaptic recruitment of GluN1 mediated by PKC in hippocampal neurons, and that PKC activation reverses NMDA receptor-mediated currents and long-term potentiation (LTP) deficits caused by CRTC1 silencing in the hippocampus. Consistent with genomics and functional data, morphological and behavioral analyses show crucial roles of CRTC1 on dendritic spine structure, plasticity, and hippocampal-dependent associative memory. Our results support a model in which neuronal activity and synaptic inputs are integrated in the nucleus through conserved CREB/CRTC1-regulated transcriptional programs sustaining global synapse-to-nucleus signaling pathways impacting on synaptic plasticity and memory.
Lack of RNase HI affects virulence inSalmonella enterica
Authors: Jiménez-Espadafor Julia , Ortiz-Padilla Miriam , Pedraza-Delgado Diego A. , Bernal-Bayard Joaquín , Ramos-Morales Francisco , Balbontín Roberto 
Published: January 2025

AbstractBacterial virulence and antibiotic resistance are interconnected global threats that can synergize, multiplying their adverse effects on health and economy. Two proposed strategies to address this dual challenge are non-biocidal inhibition of virulence traits (anti-virulence strategy) and manipulation of eco-evolutionary dynamics in bacterial populations to hamper dissemination of antibiotic resistance (anti-resistance strategy). These strategies require to identify factors involved in bacterial gene expression, fitness and evolution. R-loops strongly influence these traits, as well as fitness of bacteria carrying antibiotic resistance mutation, making the enzyme responsible for R-loop degradation, the RNase HI, a promising target for anti-resistance approaches. Interestingly, the extensive involvement of R-loops in transcription initiation and termination could also make RNase HI a potential target for anti-virulence strategies. Here we explored this possibility by investigating the effects of RNase HI deficiency on traits associated with pathogenicity in the human pathogenSalmonella entericaserovar Typhimurium. We found that lack of RNase HI alters expression of virulence genes at population and single-cell levels, and bothex vivoand during infection of mammalian cells. Moreover, we showed that RNase HI depletion causes defects in phenotypes associated with virulence, such as motility, biofilm formation, and resistance to low pH. Coherently, we observed that the absence of RNase HI reducesSalmonella’s ability to survive within macrophages. Altogether, our results demonstrate the influence of R-loops on bacterial virulence, suggesting that RNase HI could serve as a target for anti-virulence strategies. This provides a theoretical framework for the development of dual anti-resistance and anti-virulence interventions based on RNase HI targeting.
Unveiling the factors shaping innovation: a comparative analysis of emerging and advanced Asian economies
Authors: Pal Shreya , Mahalik Mantu Kumar , Mallick Hrushikesh 
Published: January 2025

Purpose
This study examines the role of monetary and fiscal policies in shaping innovation for a balanced panel sample of seven emerging and five advanced Asian economies.

Design/methodology/approach
Using the Driscoll–Kraay estimator as a baseline technique and panel-corrected standard errors and kernel-based regularised least squares as robust methods, this study explores the factors that influence innovation in both emerging and advanced Asian economies from 1990 to 2021. Based on the Morgan Stanley Capital International categorisation, this study has used a sample of seven emerging and five advanced Asian nations to empirically understand the factors shaping innovation.

Findings
The findings indicate that broad money and economic growth have positive effects on innovation, whereas tax revenue, governance quality and economic globalisation indicate negative effects in emerging Asia. The findings further indicate that tax revenue, economic growth, governance quality and economic globalisation favour innovation in advanced Asia. The authors also find an adverse impact of broad money on total innovation in advanced Asia.

Originality/value
These findings are quite helpful for the stakeholders and policymakers looking for efficient and long-lasting innovation initiatives.
Benchmarking higher education excellence: insights from QS rankings
Authors: Qazi Abroon , Al-Mhdawi M.K.S. 
Published: January 2025

PurposeThis study aims to address a gap in traditional university ranking methodologies by investigating the interrelations among key indicators featured in the QS rankings, within the broader context of benchmarking in higher education.Design/methodology/approachUtilizing the 2024 QS ranking data and a Bayesian Belief Network (BBN) model, this research explores the interconnected relationships among indicators such as “academic reputation,” “employer reputation,” “faculty-to-student ratio,” “sustainability” and others to predict university rankings.FindingsThe developed model achieves 80% predictive accuracy and shows that strong performance in “employment outcomes,” “academic reputation” and “employer reputation” contributes to higher overall scores. In contrast, weaker performance in “academic reputation” and “sustainability” is associated with lower scores. Among these factors, “academic reputation” is the most informative indicator for predicting the overall score.Originality/valueThis research contributes to the literature by emphasizing the interconnections among ranking criteria and advocating for network-based models for benchmarking in higher education. Particularly, it underscores the importance of “sustainability” in forecasting rankings, aligning well with the broader theme of predicting university performance and societal impact. This study offers valuable insights for researchers and policymakers, promoting a comprehensive approach that considers the interdependencies among criteria to enhance educational quality and address societal change within the framework of benchmarking in university rankings.
“Pharma’s secret weapon”: unleashing supply chain potential through supplier relationship management practices
Authors: Mafanele Percy , Maziriri Eugine Tafadzwa , Masakale Alfred Mojalefa , Mabuyana Brian 
Published: January 2025

PurposeThe study explored how supplier evaluation, selection, development and segmentation affect supply chain performance in pharmaceutical organizations. It also determined the moderating influence of top management support on the link between supply chain performance and organizational performance.Design/methodology/approachThe research philosophy of this study was positivism, leading to the adoption of a quantitative research method. Empirical data were gathered from a significant sample of supply chain experts at leading pharmaceutical companies in South Africa. Data collection scales were derived from existing studies. The collected data were analysed using structural equation modelling.FindingsThe results confirmed the validity of the proposed model, which is based on selected criteria (latent variables). This study emphasizes the crucial influence of supplier evaluation, selection, development and segmentation on supply chain performance in pharmaceutical organizations. The research shows a positive correlation between supply chain performance and organizational performance, with top management support playing a moderating role.Originality/valueThe study’s originality and value stem from its thorough examination of how supplier relationship management practices affect supply chain performance and organizational performance in the pharmaceutical industry of South Africa. Furthermore, the research adds to the current body of knowledge by considering the moderating influence of top management support on the link between supply chain performance and organizational performance. These findings offer valuable insights for academics and industry professionals in the realm of supply chain management.
A matter of mindset? Features and processes of newsroom-based corporate communication in times of artificial intelligence
Authors: Rohrbach Tobias , Makhortykh Mykola 
Published: January 2025

PurposeMany companies adopt the corporate newsroom model to streamline their corporate communication. This article addresses why and how corporate newsrooms transform corporate communication following the rise of artificial intelligence (AI) systems.Design/methodology/approachThis research draws on original data from 13 semi-structured interviews with executive communication experts in large Swiss companies that use corporate newsrooms.FindingsCorporate newsrooms serve as an organisational (rather than spatial) coordination body for topic-oriented and agile corporate communication. To enable their functionality, it is crucial to find the right balance between optimising and stabilising communication structures. Newsrooms actively adopt AI both to facilitate routine and enable more innovative applications, such as living data archives and channel translations. Interviews also highlight an urgent need for regulatory frameworks of AI in corporate communication.Practical implicationsThis article provides (currently lacking) insights into the practical challenges and coping strategies for establishing and managing corporate newsrooms.Originality/valueThis research addresses the gap in corporate newsroom research regarding a limited understanding of how newsrooms are implemented, managed and adapted to AI-related innovations.
Changes in the board of directors’ number of meetings: why and so what?
Authors: Haque Md Reiazul , Islam Saiful , Chowdhury Sourav Paul , Hossain Md. Alamgir , Hassan Md Ziaul 
Published: January 2025

Purpose
This study aims to investigate the potential link between prior-year banking performance and a change in the number of board of directors’ meetings in the current year and understand how changes in board meetings might impact subsequent bank performance.

Design/methodology/approach
The sample is drawn from 42 banks in Bangladesh from 2011 to 2019, and the data are analyzed using multivariate regressions. Potential endogeneity concerns are addressed using the entropy balance matching approach.

Findings
This study presents two key findings: first, the change in the number of board meetings in a year is influenced by bank performance in the last year, where poor performance leads to more meetings, and second, an increase in the number of board meetings contributes to enhanced bank performance.

Originality/value
This is one of the few studies to explore the reasons behind changes in the board of directors’ meeting behavior and whether such changes benefit banks. The results highlight that a decline in bank performance prompts the board to meet more often, and this proactive response helps banks overcome the poor performance problem. Thus, this study underscores the significance of the board’s adaptive behavior in tailoring the number of meetings according to the bank’s specific circumstances.
Information literacy as a desideratum for lifelong learning and creativity: a developing country’s perspective
Authors: Asif Muhammad , Naveed Muhammad Asif 
Published: January 2025

Purpose
Information literacy (IL) is essential to prepare lifelong learners and a creative workforce in the digital information landscape. This study aims to investigate the effect of IL on the lifelong learning and creativity of medical students in Pakistan.

Design/methodology/approach
Survey research design, along with a questionnaire, was used to collect data from students, recruited through a stratified convenient sampling process, from the medical colleges with permission from competent authorities. The administration of the questionnaire was done personally, and a total of 500 responses were received. The data were analyzed by applying descriptive and inferential statistics.

Findings
The results indicated that these medical students perceived themselves as information literate in basic IL skills. Furthermore, the IL skills appeared to have a direct, statistically significant, but positive effect on their lifelong learning and creativity.

Practical implications
The research outcomes may inform academia, particularly associated with medical education, to initiate IL instruction programs for medical students to develop IL capabilities.

Originality/value
This research would be an invaluable contribution to the existing IL literature because of the dearth of empirical studies examining the interrelationships between IL, lifelong learning and creativity.
Supporting opinions to fit in: a spiral of silence-theoretic explanation for establishing echo chambers and filter bubbles on social media
Authors: Haug Maximilian , Maier Christian , Gewald Heiko , Weitzel Tim 
Published: January 2025

PurposeSocial media communities contain like-minded members who disclose opinions about various topics that are important to them. These communities often function as echo chambers, filter bubbles or separate spaces for users to share conforming opinions and discredit others deliberately. In extreme cases, they build their alternative reality with limited information that can lead to real-world action, as seen in the storming of the capitol. Therefore, we need to better understand the mechanisms of opinion disclosure in such communities.Design/methodology/approachWe base our research on the spiral of silence theory to understand both trait-based and state-based fear of isolation as the mechanism that prevents opposing opinions in three scenarios focusing on topics dominating the mainstream US media landscape at that time: immigration, presidential election and COVID-19. We recruited 164 participants from an online research platform and analyzed the data using structural equation modeling.FindingsOur results reveal empirical evidence that state-based fear of isolation prompts community members to express agreement and support for the community’s opinion, regardless of their views. We show that hot-button issues impose an even greater danger of establishing an environment in online communities that becomes an echo chamber of filter bubbles.Originality/valueThe spiral of silence theory provides a fine-grained understanding of the concept of fear of isolation, which was either used as a trait or as a state. Furthermore, we go beyond the initial hypotheses of the spiral of silence and show that within online communities, members stay silent and start to argue against their own opinions.
Viewpoints of nurse auditors regarding the profession: a qualitative study
Authors: Aydogdu Ana Luiza Ferreira 
Published: January 2025

PurposeThis study aims to understand the experiences of Brazilian nurse auditors in the practice of their profession, exploring the importance, challenges, rewards and strategies related to the occupation.Design/methodology/approachThis is a qualitative descriptive study conducted with 44 nurse auditors. An online, open-ended questionnaire was used. Thematic content analysis was performed.FindingsFive themes were identified: (1) functions of a nurse auditor; (2) skills required for a nurse auditor; (3) learning to be a nurse auditor; (4) advantages of being a nurse auditor and (5) challenges faced by a nurse auditor. Also, a total of 16 subthemes were presented.Research limitations/implicationsThe study critically examined essential aspects of auditing through the lens of nurse auditors, addressing a relevant topic. However, limitations must be acknowledged, including the use of self-report questionnaires, regional representation disparities, the scarcity of international articles on the topic and potential researcher bias.Practical implicationsThe study underscores the importance of increasingly integrating nurse auditors into the workforce while emphasizing the need to enhance the capacitation of these professionals through theoretical and practical education. It highlights the significance of educating other multidisciplinary team members about the nurse auditor’s crucial role in fostering teamwork and ensuring the quality of healthcare services.Originality/valueTo the best of the author’s knowledge, this is the first study conducted with Brazilian nurse auditors, exploring crucial aspects of auditing from the perspective of these professionals. Understanding the critical role of nurse auditors in maintaining and improving healthcare quality can enhance public trust in healthcare systems.
Top management commitment, institutional pressures and green supply chain practices: pathways to sustainable performance
Authors: Haldorai Kavitha , Kim Woo Gon , Phetvaroon Kullada 
Published: January 2025

PurposeBy integrating upper echelon theory and institutional theory, this study investigates the influence of top management commitment to sustainability on sustainable performance. Additionally, the mediating role of green supply chain management practices and the moderating role of institutional pressure are examined.Design/methodology/approachData were collected from 376 managers and employees in green hotels within the Thai hospitality industry using a time-lagged survey.FindingsThe findings reveal that top management commitment to sustainability positively influences sustainable performance and that green supply chain management practices mediate this relationship. Additionally, coercive and normative pressures moderated the relationship between top management commitment to sustainability and green supply chain management practices.Practical implicationsThis study highlights the importance of green supply chain management practices for hospitality firms. It emphasizes that strong leadership commitment to sustainability, partnerships with suppliers and compliance with regulations are crucial for the successful implementation of green supply chain initiatives.Originality/valueThis study contributes to the literature by providing empirical evidence about the mechanisms through which top management commitment to sustainability translates into improved sustainable performance. Furthermore, the study enhances our understanding of how external pressures, specifically coercive and normative pressures, influence the adoption of green supply chain practices, offering new insights into how contextual factors shape management actions regarding sustainability. This adds nuance to our understanding of the interplay between internal commitment and external pressures in driving sustainability outcomes in the hospitality industry.
Examining metaverse experiences of people traveling to Turkey amid massive migration waves
Authors: Talay Ömür 
Published: January 2025

Purpose
This study aims to examine the metaverse experiences of individuals traveling to Turkey, a nation with a complex history of migration, and to assess the influence of these experiences on their accommodation processes within host countries.

Design/methodology/approach
A qualitative approach, using semi-structured interviews, explored participants’ Metaverse experiences. Thematic analysis was applied to the interview data. The participant statements were coded, and concept maps were created.

Findings
The findings indicate that metaverse technologies can significantly facilitate planning for both short-term travelers and temporary migrants to migration hotspots, mitigating anxieties associated with the unfamiliar, and expediting the adaptation process by enabling virtual exploration of such destinations.

Originality/value
The research uniquely explores how metaverse and related technologies can enhance hospitality experiences in destination countries, particularly those facing challenges from irregular migration. Unlike previous studies, it specifically focuses on the metaverse experiences of people traveling to these destinations, aiming to answer the crucial question of how effective these technologies are in improving the hospitality experience in such contexts.
The impact of online brain-spotting therapy on brain metabolism and PTSD symptoms of intimate sexual violence victims: a single case study
Authors: Foo Mariana , Himawan Karel Karsten , Susanto Eko 
Published: January 2025

Purpose
This study aims to evaluate the effectiveness of online brainspotting (BSP) therapy in reducing posttraumatic stress disorder (PTSD) symptoms and influencing brain metabolism in a survivor of intimate partner sexual violence.

Design/methodology/approach
A quasi-experimental single-case study using a pretest–posttest design was conducted with clinical assessments and neuroimaging techniques (Proton Magnetic Resonance Spectroscopy or H-MRS). The PTSD participant underwent 15 online BSP sessions, with a healthy control included for comparison. PTSD symptoms and neural activity, specifically the N-acetyl aspartate/creatine ratio, were evaluated before and after the intervention.

Findings
The results indicated significant reductions in PTSD symptoms and improvements in neural activity, particularly in the prefrontal cortex, medial prefrontal cortex, dorsal anterior cingulate cortex, hippocampus and amygdala. Reductions in anxiety and depression levels were also observed through clinical assessments. Follow-up sessions confirmed sustained symptom improvement.

Research limitations/implications
The small sample size and lack of randomization limit generalizability, and reliance on self-reporting could introduce bias. Future research should involve larger samples, randomized trials and longer follow-up periods.

Practical implications
This study offers preliminary evidence for the effectiveness of online BSP therapy in treating PTSD, highlighting its potential as an accessible treatment option and demonstrating the value of neuroimaging in tracking therapy outcomes.

Originality/value
The study provides novel insights into online BSP’s impact on brain regions associated with trauma and emphasizes the need for culturally sensitive PTSD treatment in Indonesia.