bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improving enzymatic performance of antioxidant enzyme catalase in combination with [Mn (phen)2Cl.H2O]Cl.tu complex
Authors: Shahraki Somaye , Shiri Fereshteh , Razmara Zohreh 
Published: February 2023

Efforts to synthesize metal complexes that have good biological potency, such as anti‐cancer or antioxidant properties, have expanded. In this study, an Mn complex containing 1,10‐phenanthroline (phen) and thiourea (tu), [Mn (phen)2Cl.H2O]Cl.tu, was selected, and its interaction with the antioxidant enzyme bovine liver catalase (BLC) was evaluated by spectroscopic and molecular docking methods. Our results showed that Mn complex interacts with BLC via a dynamic, endothermic, entropy‐driven mechanism. The binding constants (Kb) of BLC‐Mn complex were 0.62 ± 0.01, 0.73 ± 0.03, and 2.62 ± 0.09 × 103 M−1 at 303, 310, and 317 K, respectively. During complex interaction with catalase, the most important forces involved were hydrophobic forces. Considering that the quenching rate of tryptophan (Trp) was higher than that of tyrosine (Tyr), it can be concluded that Trp is closer to the Mn complex interaction site than Tyr. The CD spectra showed that the BLC secondary structure became more stable in the presence of the Mn complex and could be a reason for improving the catalytic activity of this enzyme. Molecular docking was used to predict that the Mn complex is able to bind to BLC and to identify specific residues. In general, the above Mn complex can be further evaluated as a suitable synthetic metallodrug due to its good antioxidant activity and binding function that improves the enzymatic activity of catalase.
Interplay between Elastic and Electrochemical Properties during Active Material Transitions and Aging of a Lithium‐Ion Battery
Authors: Feiler Simon , Daubinger Philip , Gold Lukas , Hartmann Sarah , Giffin Guinevere A. 
Published: February 2023

AbstractThe interplay between the internal mechanical properties and external mechanical conditions of a battery cell, e. g., Young's modulus and thickness change, has a crucial impact on the cell performance and lifetime, and thus, needs to be fully understood. In this work, 12 Ah lithium‐ion battery pouch cells were studied during cycling and aging by non‐invasive operando ultrasonic and dilation measurements. The effective Young's modulus increases and the thickness varies the most within a single cycle during the graphite transition from stage 1L to 4, at the beginning of the 2 to 1 stage transition and at the phase transition of the nickel‐rich NCM from H2 to H3. After 1000 cycles of aging, the overall effective Young's modulus of the lithium‐ion battery decreases by ∼11 %–12 % and the cell thickness increases irreversibly by ∼3 %–4 %, which is mostly related to a thicker and possibly softer, more porous solid electrolyte interphase layer.
Language as a Specimen
Authors: Solleveld Floris 
Published: February 2023

AbstractLanguage was never studied by linguists (or philologists) alone. The greater part of the languages of the world was first known in the West through the reports of missionaries, explorers, and colonial administrators, and what they documented reflected their specific interests. Missionaries wrote catechisms, primers, dictionaries, and Bible translations (especially Lord's Prayers); for explorers and administrators, language was one aspect among many to cover in their accounts of faraway regions. Peoples were identified by their language; toponyms served for geographic description; names of plants and animals were gathered together with specimens and images of plants and animals. In this context, linguistic materials were equally described as “specimens.” This article investigates the various ways in which language material was used and conceived of as a specimen, and the global trajectories of these “specimens.” Especially the role of naturalist explorers deserves closer attention in this regard. What they did, throughout the late 18th and 19th century, was gathering language material as one kind of specimen among others, Forster in the Pacific, Humboldt, Martius, and d'Orbigny in South America, and Peters in Mozambique. Two large‐scale expeditions from the mid‐19th century stand out as examples: the U.S. Exploring Expedition (1838–1842), whose collections later filled the Smithsonian Institution, and the Austrian‐Hungarian Novara expedition (1857–1859).
External physical field‐driven nanocatalytic cancer therapy
Authors: Wu Qingyuan , Zhang Haoyuan , Liu Huiyu 
Published: February 2023

AbstractRecently, variable nanocatalysts have provided novel, highly selective, minimally invasive strategies driven by external physical fields for cancer therapy. In the catalytic reaction, less toxic or nontoxic substances can be in situ converted into toxic agents for cancer suppression. In this review, we systematically summarize the catalytic cancer therapy based on different types of external physical fields, including light, ultrasound, electricity, temperature, X‐ray, magnetic field, and microwave. The properties, mechanisms, and advantages of the corresponding external physical fields in cancer therapy are also introduced. Importantly, considering the rapid development of catalytic nanomedicine, the research progress of catalytic cancer therapy driven by external physical fields is discussed. Finally, the remaining challenges and outlooks that catalytic cancer therapy faced are also outlined. We believe that the emerging external physical fields‐driven nanocatalytic cancer therapy will provide a new avenue for cancer treatment.
Electrocatalysts based on MoS2 and WS2 for hydrogen evolution reaction: An overview
Authors: Van Nguyen Tuan , Tekalgne Mahider , Nguyen Thang Phan , Van Le Quyet , Ahn Sang Hyun , Kim Soo Young 
Published: February 2023

AbstractRecently, hydrogen energy has been significantly investigated by numerous technologies. To date, noble platinum group metals have often been employed to fabricate working electrodes for hydrogen evolution reaction (HER). Therefore, the demand of highly active HER catalysts based on effective and lower‐cost materials is becoming more and more critical. Transition metal dichalcogenide (TMD) materials could be one of the most suitable materials for these requirements because they possess numerous unique mechanical, electronic, and chemical characteristics that are greatly beneficial for HER processes. Among many TMD materials, tungsten disulfide (WS2) and molybdenum disulfide (MoS2) are the most well‐known TMD materials which have been intensively studied for different applications, including HER, batteries, and supercapacitors. In this review, we tried to cover the HER mechanism of catalysts and their parameters. Besides that, the structures, properties, preparation, and HER performance of catalyst materials based on WS2 and MoS2 are comprehensively discussed. After that, the challenges and future trends of catalysts based on WS2 and MoS2 for HER are also considered.
Three‐dimensional reconstruction of the innervation of the female pelvis: A review of current methods
Authors: Tomalty Diane , Giovannetti Olivia , Velikonja Leah , Balamane Saad , Morcos Maya , Adams Michael A. 
Published: February 2023

AbstractThe three‐dimensional (3D) reconstruction of tissues is a valuable approach for elucidating the anatomy of nerves and plexuses, which are often microscopic in nature and therefore difficult to fully appreciate using gross dissection approaches alone. A common workflow which can be used to generate such 3D models has yet to be comprehensively described. This study aimed to review 3D reconstruction methodologies and findings related to human female pelvic innervation to determine whether there is an optimal methodology and identify the limitations of these approaches. A comprehensive literature review was conducted using keywords including 3D reconstruction, human female pelvic nerves, and innervation. Twenty relevant articles published between 2003 and 2019 were selected for review. The 3D reconstruction of female pelvic innervation generally follows two workflows involving either immunohistochemistry (IHC) (n = 16) or magnetic resonance imaging (MRI) (n = 4). There were commonalities among the general steps reported for 3D tissue reconstruction across these two imaging methodologies. Notably, there was some variability in study methodology across the studies reviewed, suggesting there is not a clear best practice for the reconstruction of these tissues. Information that generates 3D mapping of innervation has important clinical applications, such as informing and optimizing surgical approaches to avoid damage to local innervation. IHC and MRI‐based approaches are both feasible for the reconstruction of pelvic innervation, though there are advantages and disadvantages to both. Information from this review can be used to help inform the development of 3D models of female pelvic innervation in the future.
Three New Selaginellin Derivatives from Selaginella pulvinata and Their α‐Glucosidase Inhibitory Activity
Authors: Zhu Qin‐Feng , Luo Tian‐Tian , Chen Qian , Gao Bei‐Bei , Zeng Ai‐Fen , Ao Jun‐Li , Xu Guo‐Bo , Liao Shang‐Gao , He Xun 
Published: February 2023

AbstractThree new selaginellin derivatives, selaginpulvilins V‐X (1–3), together with seven known analogs (4–10) were isolated from whole plants of Selaginella pulvinata. Their structures were determined by extensive spectroscopic methods including 1D and 2D NMR, HR‐ESI‐MS and chemical derivatization method. Compound 1 represents a rare example of naturally occurring selaginellin with an alkynylphenol‐trimmed skeleton. Biological evaluation showed that compounds 2, 6 and 8 displayed moderate inhibition against α‐glucosidase with IC50 values of 3.71, 2.04 and 4.00 μM, respectively.
A roadmap to arrhythmias after transcatheter pulmonary valve replacement in pediatric patients
Authors: El Hajj Milad , Krajcer Zvonimir 
Published: February 2023

Key Points
In pediatric patients undergoing balloon‐expandable transcatheter pulmonary valve replacement within the native right ventricular outflow tract (RVOT), postprocedural ventricular arrhythmias were common and occurred in 33% of patients.
Patients with postprocedural ventricular arrhythmias had a benign course, and all patients with follow‐up were successfully weaned off antiarrhythmic therapy.
Patients with previous transannular patch repairs in the RVOT had an overall lower ventricular arrhythmia burden.
Electrochemical Atom Transfer Radical Addition of Polychloroalkanes to Olefins Promoted by 4,4‐Di‐tert‐butyl Bipyridine
Authors: Lian Fei , Luo Feixian , Wang Meng , Xu Kun , Zeng Chengchu 
Published: February 2023

Comprehensive SummaryA new electrochemical strategy for the atom transfer radical addition (ATRA) of polychloroalkanes across olefins has been realized by the synergism of paired electrolysis and halogen bonding activation. Notably, readily accessible 4,4‐di‐tert‐butyl bipyridine (dtbpy), acting as a halogen bonding acceptor, shifted the reduction potential of C—Cl bonds positively by 110 mV. The decreased operating potential leads to a wide substrate scope and excellent functional group compatibility. A diverse array of terminal and internal alkenes such as (hetero)aryl olefins, unactive aliphatic olefins, and natural products and drugs‐derived olefins were well compatible.
Long‐Lived Luminescence Emitted from Imide Compounds Dispersed in Polymer Matrices after Continuous Ultraviolet Irradiation and its Relation to Oxygen Quenching
Authors: Doi Marina , Ishige Ryohei , Ando Shinji 
Published: February 2023

AbstractLong‐lived room‐temperature delayed phosphorescence, called prolonged irradiation‐induced delayed luminescence (PIDL), was observed in air for three imide compounds (ICs) dispersed in polymethyl methacrylate under UV irradiation after an induction time of 1.60–6.78 min, whereas the ICs alone showed only fluorescence after a short period of UV irradiation. The PIDL emission continued as an afterglow for several seconds (0.36–1.30 s) after the irradiation was stopped. In the initial stage of irradiation, the ICs in the excited triplet state (T1) generated via intersystem crossing were immediately quenched by ground state triplet molecular oxygen (3O2), and the excited state energy of ICs was transferred by photosensitization to 3O2, generating singlet oxygen (1O2), causing a gradual depletion of the concentration of 3O2 in the host matrix. When most of the 3O2 adjacent to the ICs had been consumed, the ICs started to emit a PIDL. The induction time until the appearance of PIDL was linearly proportional to the 3O2 concentration. Optical measurements and numerical simulations based on the Jablonski diagram support the PIDL generation mechanism and reveal the relationships between the rate constants and oxygen permeabilities of the host matrices.
Overview of Admixture Mapping
Authors: Shriner Daniel 
Published: February 2023

AbstractAdmixture mapping is a powerful method of gene mapping for diseases or traits that show differential risk by ancestry. Admixture mapping has been applied most often to Americans who trace ancestry to various combinations of Native Americans, Europeans, and West Africans. Recent developments in admixture mapping include improvements in the methods and reference data needed to make inferences about ancestry as well as extensions of the mapping approach in the framework of linear mixed models. This overview outlines the key concepts of admixture mapping. It describes approaches for inferring local ancestry and provides strategies for performing admixture mapping depending on the study design. Finally, linkage analysis, association analysis, and admixture mapping are compared, with an emphasis on integrating admixture mapping and association testing. Published 2023. This article is a U.S. Government work and is in the public domain in the USA.
Generic Model for Plant Uptake of Ionizable Pharmaceuticals and Personal Care Products
Authors: Trapp Stefan , Shi Junxuan , Zeng Landi 
Published: February 2023

Abstract
Plant uptake of pharmaceuticals and personal care products (PPCPs) has been recognized as a potential path to human exposure. Most existing regressions and uptake models are limited to neutral organic compounds, but 80% of pharmaceuticals and an unknown number of personal care products ionize under environmentally relevant conditions. A widely used generic plant uptake model was expanded step-by-step with processes relevant for weak and strong acids and bases, such as ionization, membrane permeability, ion trap, phloem transport, and sorption to proteins. The differential equation system was solved analytically, and the equations were implemented in a spreadsheet version. The changes in predicted plant uptake of neutral substances, acids, and bases were found for a range of key input data (log KOW, pKa, pH, sorption to proteins). For neutral compounds, sorption to proteins and phloem transport are of relevance only for the more polar compounds (low log KOW, ≤2). Weak acids (pKa ≤6) are trapped in phloem due to pH-related effects, and in roots when pH in soil is low (pH 4–5). Cations sorb stronger and hence show less bioavailability and less translocation than anions. Sorption to proteins reduces translocation to leaves and fruits for all substances, but this is more evident for polar and ionic compounds that have negligible sorption to lipids. The new generic model considers additional processes that are of relevance for polar and ionizable substances. It might be used instead of existing standard approaches for chemical risk assessment and assessment of the environmental fate of PPCPs. Environ Toxicol Chem 2023;42:793–804. © 2023 The Authors. Environmental Toxicology and Chemistry published by Wiley Periodicals LLC on behalf of SETAC.
Abstract
Most existing regressions and uptake models are limited to neutral organic compounds, but 80% of pharmaceuticals and many personal care products ionize under environmentally relevant conditions. Quantification of their plant uptake requires the consideration of additional processes. PPCPs, Pharmaceuticals and personal care products.
Cross‐sectional associations between healthy eating index and thyroid function in U.S. male Adults, NHANES 2007–2012
Authors: Chen Yiqiu , Han Ting 
Published: February 2023

AbstractLittle is known about whether diet quality is associated with thyroid function. We aimed to examine the relationship between diet quality and thyroid function. Data were from the National Health and Nutrition Examination Surveys, 2007–2012. A total of 3603 males who were at least 20 years old and had dietary recall data were included in the analysis. Thyroid function was assessed by eight indexes, including total and thyroglobulin antibodies, thyroid peroxidase antibodies, free T4 and T3, total T4 and T3, Tg, and thyroid‐stimulating hormone. Multivariable linear regression, subgroup analyses, and interaction terms were employed to test the association between healthy eating index (HEI) and thyroid function. A total of 3603 male participants aged ≥20 years with an average age of 48.17 ± 0.51 years were enrolled. We found a negative association between HEI‐2010 and total T3 (β = −3.41; p = .01) and free T3 (β = −0.06; p = .01). In subgroup analyses, HEI‐2010 was negatively associated with TT3 in male participants aged <65 years old (β = −4.57; p < .01) and FT3 (β = −0.09; p < .001). Higher HEI‐2010 was inversely associated with lower total T3 and free T3. More well‐designed studies are still needed to validate the causal relationship between HEI and thyroid function.
Benzo[b]fluoranthene induced oxidative stress and apoptosis in human airway epithelial cells via mitochondrial disruption
Authors: Bao Qixue , Zhao Shanshan , Liu Yongqi , Yao Yuqin , You Jia , Xiong Jingyuan 
Published: February 2023

AbstractBenzo[b]fluoranthene (BbF) is a common constituent of polycyclic aromatic hydrocarbons (PAHs). While numerous studies revealed adverse effects of PAHs on human health, the health effects of individual PAHs differ, and few investigations were performed on BbF. Therefore, the present study established cytotoxicity models of human lung epithelial cells (BEAS‐2B cells) and bronchial epithelial cells (16HBE cells) exposed to BbF (10, 20, and 40 μM) for 24 h to reveal the mechanisms. Results from cytotoxicity and proliferation studies demonstrated that BbF inhibited cell growth in a dose‐dependent manner. Flow cytometric analysis showed that BbF induced the appearance of a sub G1 peak, S‐phased arrest, and apoptosis in both cells. Mechanistic investigations illustrated that BbF promoted reactive oxygen species (ROS) production, altered the expression of oxidative stress indicators, and decreased mitochondrial membrane potential. BbF also interfered with the expression of regulators associated with mitochondria disruption pathway. Taken together, these results strongly suggested that BbF inhibited cell growth and induced apoptosis in human airway epithelial cells via ROS‐mediated mitochondria disruption.
Influence of fine‐grained structure produced by groove pressing on the properties of pure Mg and commercial ZE41 alloy
Authors: Sahu Manas Ranjan , Sampath Kumar T. S. , Chakkingal Uday , Dewangan Vimal Kumar , Doble Mukesh 
Published: February 2023

AbstractBiodegradable metals are important for temporary implant applications. However, poor mechanical properties and higher degradation rate of Mg and its commercial alloys is a major disadvantage. In this study, the above properties were tailored using the groove pressing (GP) technique. Uniform fine‐grained (UFG) pure Mg and ZE41 alloy were obtained using GP technique. The impact of GP‐induced microstructural changes and surface characteristics on mechanical performance, degradation behavior, biomineralization, surface wettability, and cytocompatibility were investigated. The groove‐pressed pure Mg and ZE41 alloy had grain sizes of approximately 30 ± 7.8 and 25 ± 7.5 μm, respectively. The hardness of groove‐pressed pure Mg and ZE41 alloy increased by 40% and 26%, respectively, when compared to the annealed condition. Enhanced strength and elongation were observed with these samples. The potentiodynamic polarization test showed a higher Ecorr and lower Icorr values for groove‐pressed sample when compared to the annealed condition indicating decreased degradation rate. The weight loss data from immersion tests also show that the degradation rate decreases with time confirming the surface passivity of the sample. The degradation rate decreased by 37% and 44% in simulated body fluid for pure Mg and ZE41 alloy, respectively, after GP. The higher hydroxyapatite deposition on the groove‐pressed sample than the annealed sample, as observed from surface morphology studies after immersion in simulated body fluid, confirms the increased biomineralization tendency after GP. The higher wettability of the groove‐pressed sample leads to higher cell adhesion and cell viability when compared to the annealed sample indicating higher biocompatibility.
Ultrasound and fetal magnetic resonance imaging: Clinical performance in the prenatal diagnosis of orofacial clefts and mandibular abnormalities
Authors: Tonni Gabriele , Peixoto Alberto Borges , Werner Heron , Grisolia Gianpaolo , Ruano Rodrigo , Sepulveda Francisco , Sepulveda Waldo , Araujo Júnior Edward 
Published: February 2023

AbstractCleft lip, with or without cleft palate, is the most common congenital craniofacial anomaly and the second most common birth defect worldwide. Micrognathia is a rare facial malformation characterized by small, underdeveloped mandible and frequently associated with retrognathia. Second‐ and third‐trimester prenatal ultrasound is the standard modality for screening and identification of fetal orofacial abnormalities, with a detection rate in the low‐risk population ranging from 0% to 73% for all types of cleft. The prenatal ultrasonography detection can also be performed during the first trimester of pregnancy. Given the potential limitations of obstetric ultrasound for examining the fetal face, such as suboptimal fetal position, shadowing from the surrounding bones, reduce amniotic fluid around the face, interposition of fetal limbs, umbilical cord and placenta, and maternal habitus/abdominal scars, the use of adjunct imaging modalities can enhance prenatal diagnosis of craniofacial anomalies in at‐risk pregnancies. Fetal magnetic resonance imaging (MRI) is a potentially useful second‐line investigation for the prenatal diagnosis of orofacial malformations with a pooled sensitivity of 97%. In this review, we discuss the role of ultrasound and fetal MRI in the prenatal assessment of abnormalities of the upper lip, palate, and mandible.