bluuebunny/crossref_metadata_2025_split huggingface dataset:
A stakeholder-developed logic model to improve utilization of pharmacy-prescribed contraception in Utah
Authors: Simmons Rebecca G. , Baayd Jami , Tak Casey , Turok David K. , Elliott Sarah , Smith Justin D. 
Published: April 2023

Abstract
Background: Currently, 17 states have passed policies allowing pharmacists to prescribe short-acting hormonal contraception, including pills, patches, and vaginal rings. Yet, utilization of these services remains limited. The purpose of this study was to a) assess barriers and facilitators of pharmacy contraceptive dispensing among contraceptive users, pharmacists, and healthcare providers in Utah; and b) adapt and propose an evidence-based contraceptive intervention in the pharmacy environment.
Methods: We conducted 6 focus groups among contraceptive users, pharmacists and healthcare providers assessing current barriers and facilitators to pharmacy prescribing. We coded transcripts of these focus groups to the Consolidated Framework for Implementation Research 2.0 (CFIR) and characterized the findings based on the Expert Recommendations for Implementing Change (ERIC) Barrier-Busting tool. Based on the CFIR findings and ERIC strategies output, we adapted an existing evidence-based intervention (a contraceptive access initiative) to the Utah pharmacy environment. We then convened a pharmacy stakeholder meeting and presented elements of an Implementation Research Logic Model and obtained feedback. We coded this feedback to the CFIR framework to finalize an Implementation Research Logic Model for a proposed implementation approach to improving contraceptive prescribing.
Results: Initial focus group responses clustered around specific implementation barriers including financial barriers (cost for patients, as well as lack of reimbursement for pharmacist’s time); lack of awareness of the service (on the part of patients, pharmacists and health care providers); need for updated tools for contraceptive counseling and scheduling; and need for increased pharmacists education to conduct contraceptive counseling. Proposed adaptations to the existing contraceptive access intervention included development of a technology-based patient/pharmacist screener tool and a healthcare provider/pharmacist contraceptive referral network. Stakeholders identified pharmacist reimbursement as the top priority for improving utilization.
Conclusions: Elements of contraceptive access initiatives mapped well as proposed implementation strategies to improving utilization of contraceptive prescribing in pharmacies.
The space cold atom interferometer for testing the equivalence principle in the China Space Station
Authors: Chen Xi , He Meng , Li Jinting , Zhang Danfang , Fang Jie , Ge Guiguo , Wang Wenzhang , Zhou Yang , He Chuan , Zhou Lin , Wang Yibo , Li Xiao , Xu Rundong , Xiong Zongyuan , Zhang Xiaowei , Zhong Jiaqi , Chen Qunfeng , Sun Huanyao , Lei Qin , Chen Zhiyong , Li Kuo , Zheng Guo , Peng Weihua , Wang Jin , Zhan Mingsheng , Wang yan , Cai Zhendi , Jiang Junjie 
Published: April 2023

Abstract
The precision of the weak equivalence principle (WEP) test using atom interferometers (AIs) is expected to be extremely high in microgravity environment. The microgravity scientific laboratory cabinet (MSLC) in the China Space Station (CSS) can provide a higher-level microgravity than the CSS itself, which provides a good experimental environment for scientific experiments that require high microgravity. We designed and realized a payload of a dual-species cold rubidium atom interferometer. The payload is highly integrated and has a size of 460 mm × 330 mm × 260 mm. It will be installed in the MSLC to carry out high-precision WEP test experiment. In this article, we introduce the constraints and guidelines of the payload design, the compositions and functions of the scientific payload, the expected test precision in space, and some results of the ground test experiments.
Field Tested: Assessing the Transferability of Behavioral Interventions
Authors: Saccardo Silvia , Dai Hengchen , Han Maria , Vangala Sitaram , Hoo Juyea , Fujimoto Jeffrey 
Published: April 2023

Abstract
Applied behavioral science has grown rapidly in the past few decades as organizations and governments seek to incorporate research on human behavior into policy decisions1. At the same time, there is a growing recognition of the need to examine the robustness of empirical findings and their transferability to consequential behaviors2,3,4. Here, focusing on an important policy domain—COVID-19 booster uptake—we investigate the transferability of findings a) from prediction surveys and hypothetical experiments to field settings; and b) from one field context at one point in time to another after evolving circumstances. Across three preregistered randomized controlled trials (RCTs, total N=317,175), we tested text-based interventions that either were expected to work by behavioral scientists and laypeople (RCT1), successfully elevated vaccination intentions in online studies (RCT1 and RCT2), or effectively increased vaccination rates in prior field work (RCT3). Our research highlights the importance of field-testing interventions, as findings based on predictions and intentions fail to transfer to our real-world setting. We also find that despite repeated exposure to COVID-19 messaging in our population, reminders and psychological ownership framing still increased booster uptake. These findings have theoretical and practical implications, as they can contribute to refining both theories of behavior change and experts’ predictions about what interventions are likely to have an impact in the field.
Ambroxol hydrochloride spray (Luo Runchang®) in the treatment of acute respiratory infectious diseases: A prospective, multicenter, open label, randomized controlled study
Authors: Cheng Lu , Liu Min , Wang Rong , Cao Sufen , Li Rui , Su Bo , Wei Hongyan , Yang Haijuan , Hou Lingyun , Ge Chunyu , Han Yuling , Yang Tianrui 
Published: April 2023

Abstract
Purpose Cough and sputum are the most common clinical symptoms of acute respiratory tract infection. Ambroxol is a mucolytic expectorant commonly used in clinical practice. This study aims to evaluate the efficacy, safety, and compliance of ambroxol hydrochloride spray (Luo Runchang ®) for the treatment of acute respiratory tract diseases in children.Methods In this multicenter, open-labeled, randomized controlled study, 154 subjects were randomized and included in the analysis. The experimental group received ambroxol hydrochloride sprays, and the control group received ambroxol hydrochloride oral solutions. The primary endpoint was the change in cough symptom scores from baseline. Secondary endpoints include changes in cough severity score, quality of life, adherence, and adverse events.Results The mean change of total cough symptom score of the spray group at the end of treatment was − 4.7(1.54) compared to -4.2(1.62) in the solution group (P = 0.0005). The mean change of cough severity score was − 5.7(2.09) in the spray group compared to -5.2(2.04) in the solution group (P = 0.012). Quality of life scores significantly improved in the spray group (P < 0.0001). Medication adherence markers were significantly better in the spray group (P < 0.0001). The incidence of adverse events in the experimental group (1.33%) was lower than that in the control group (6.33%), but the difference between the groups was not statistically significant.Conclusion Ambroxol hydrochloride spray significantly improved cough symptom score, cough severity score, and quality of life score compared to ambroxol hydrochloride oral solution.
ISSI2022+Simulation study on repair welding residual stress of CrMo steel high-temperature pressure pipe weldment after extended service
Authors: Yang Bin , Xiu Minghao , Jiang Wenchun , Peng Wei 
Published: April 2023

Abstract
Repair welding is a common method to mitigation of damaged parts including creep voids and cracks in high temperature pressure pipelines. However, new cracks may be created due to the mechanical property degradation of aging material and excessive repair welding residual stress. In order to make a scientific and reasonable life extension or replacement decision, this paper carried out a feasibility study on the repair welding of an aged CrMo steel high temperature pressure pipe weldment. Firstly, the modified Kachanov-Rabotonov creep damage constitutive equation was used to predict the creep damage distribution of the weldment served for 26 years, and the most serious damage location for scarfing is determined. Then, the simulation study of welding residual stress was carried out with focus on the influence of material performance degradation and excavation methods. The results show that the maximum creep damage of the CrMo steel pipe weldment is concentrated in the heat affected zone (HAZ) and the adjacent base metal (BM).In total, the repair welding stress simulated with the degraded mechanical properties are lower than that with the initial mechanical properties. But, the stress discontinuity at the interface between the repair welding zone and BM is more severe due to the high level mismatch of mechanical properties, which is a key risk inducing repair welding cracks.The step repair method is recommended for engineering application based on the consideration from aspects of avoidance of the stress concentration inside the weld, and weaken the stress discontinuity of the weld boundary.
Spatio-temporal variation of toxin-producing gene abundance in Microcystis aeruginosa from Poyang Lake
Authors: Wu Lin , Zhang Li , Yuan Lijuan , Liao Qiegen , Xiang Jianjun , Zhang Dawen , Qiu Tong , Liu Jutao , Guo Junhui 
Published: April 2023

Abstract
Microcystis aeruginosa causes massive blooms in eutrophic freshwater and releases microcystin. Poyang Lake is the largest freshwater lake in China and has kept at a mid-nutrient level in recent years. However, there is little research on microcystins production in Poyang Lake. In this study, water and sediment samples from ten sampling sites in Poyang Lake were collected from May to December in 2020, and from January to April in 2021 respectively. Microcystis genes (mcyA,mcyB,16s rDNA) were quantified by real-time fluorescence quantitative PCR analysis,and then the spatial and temporal variation of mcy genes, physicochemical factors and bacterial population structure in the lake was analyzed. The relationship between the abundance of mcy genes and physicochemical factors in water column were also revealed. Results indicated that the microcystin-producing genes mcyA and mcyB showed significant differences in spatial and temporal levels as well, which is closely related to the physicochemical factors especially the water temperature(p < 0.05) and the nitrogen content(p < 0.05). The abundance of mcy genes in the sediment in December affected the abundance of mcy genes in the water column in the next year, while the toxic Microcystis would accumulate in the sediment. In addition to the toxic Microcystis, we also found a large number of non-toxic Microcystis in the water column and sediment, the ratio of toxic to non-toxic species can also affect the toxicity production of Microcystis aeruginosa. Overall, the results showed that Microcystis aeruginosa toxin-producing genes in Poyang Lake distributed spatially and temporally which related to the physicochemical factors of Poyang Lake.
Adequacy of cancer-related pain management and associated factors among cancer patients in Northwest Ethiopia a multicentre cross-sectional study
Authors: Aschale Endalamaw , Bayafers Fasil , Solomon Tewodros 
Published: April 2023

Abstract
Background: Pain is the most frequent problem and deleterious symptom reported by cancer patients. It is a persistent, distressing, and life-threatening condition that markedly affects the quality of life of cancer patients all over the world. Despite the availability of numerous standards for cancer-related pain treatment, studies from throughout the world show that patients often receive poor pain management.
Objective: This study aims to assess the adequacy of cancer-related pain management and associated factors among cancer patients in Northwestern Ethiopia
Method: A hospital-based multicenter cross-sectional study was conducted in Northwestern Ethiopia from May to July 2022. In cancer patients, a systematic random sampling technique was used to select representatives from each study area. Data were analyzed using SPSS version 26 software, and variables were described using frequencies and proportions. Bivariable logistic regression was conducted to determine independent predictors of the adequacy of cancer-related pain management. A p-value of < 0.05 was considered statistically significant.
Results:A total of 422 participants were included, and more than half of them 249 (59%) were female. Less than half of the participants, 108 (25.6%) and 174 (41.2%) have a history of pain and metastasis, respectively. All the participants experience cancer-related pain with varying degrees of severity. About 67.5% of the participants had adequate cancer-related pain management (CI; 62.8-72). Patients with good performance status and a previous history of pain were likely to have inadequate pain management.
Conclusion; Using pain management index status in Northwestern Ethiopia, 67.5% of patients with cancer-related pain obtain adequate pain management. The adequacy of cancer-related pain management was found to be influenced by factors like comorbidity, past pain history, and Eastern cooperative oncology group performance status.
ESCO2's Oncogenic Role in Human Tumors: A Pan-Cancer Analysis and Experimental Validation
Authors: Huang Yue , Chen Dapeng , Bai Yi , Zhang Yamin , Zheng Zhiwen , Fu Qingfeng , Yi Bocun , Jiang Yuchen , Zhu Jianqiang , Zhang Zhihong 
Published: April 2023

Abstract
Purpose: Establishment of Sister Chromatid Cohesion N-Acetyltransferase 2 (ESCO2) is a member of histone acetyltransferases. ESCO2 is involved in the mitotic S-phase adhesins acetylation and is responsible for bridging two sister chromatids. However, present ESCO2 cancer research is limited to a few cancers. No systematic pan-cancer analysis has been conducted to investigate its role in diagnosis, prognosis, and effector function.
Methods:We thoroughly examined the ESCO2 carcinogenesis in pan-cancer by combining public databases such as The Cancer Genome Atlas (TCGA), Genotype-Tissue Expression Project (GTEx), cBioPortal, Human Protein Atlas (HPA), UALCAN, Xena Shiny databases, and TISCH. The analysis includes differential expression analysis, survival analysis, cellular effector function, gene mutation, single cell analysis, and tumor immune cell infiltration. Furthermore, we confirmed ESCO2's impacts on ccRCC cells' proliferative and invasive capacities in vitro.
Results: In our study, ESCO2 is overexpressed in most cancers and has prognostic, predictive ability in various cancers. Moreover, ESCO2 expression positively correlates with tumor stage, grade, and tumor metastasis in several cancers. Function analysis revealed that ESCO2 participates in mitosis, cell cycle, DNA damage repair, and other processes. CDK1 was identified as a downstream gene regulated by ESCO2. Furthermore, ESCO2 might also be implicated in immune cell infiltration. Finally, ESCO2'S knockdown significantly inhibited the A498 cells' proliferation, invasion, and migration.
Conclusions: In conclusion, ESCO2 is a possible pan-cancer biomarker and oncogene that can reliably predict the prognosis of cancer patients. ESCO2 was also implicated in the cell cycle and proliferation regulation. In a nutshell, ESCO2 is a therapeutically viable and dependable target.
Single-cell profiling of mosquito spermatogenesis defines the onset of meiotic silencing and pre-meiotic overexpression of the X chromosome.
Authors: Page Nicole , Taxiarchi Chrysanthi , Tonge Daniel , Chesters Emily , Kuburic Jasmina , Game Laurence , Nolan Tony , Galizi Roberto 
Published: April 2023

Abstract
Understanding of the Anopheles gambiae germline has been essential to acquiring effective genetic control strategies targeting this malaria mosquito vector. This includes targeting germline genes to induce sterility or using regulatory sequences to drive transgene expression for applications such as gene drive. However, only very few germline regulatory elements have been characterised with the majority showing leaky expression. This has been shown to significantly reduce the efficiency of current genetic control strategies, which rely on regulatory elements that are more tightly restricted in their spatial and/or temporal expression. Additionally, meiotic silencing of the sex chromosomes during spermatogenesis limits the flexibility of transgene expression for design of novel genetic control strategies. In this work, we build on our previous study that dissected gametogenesis into four distinct cell populations. We used single-cell RNA sequencing to further discriminate these populations and define distinct germline cell-types. In doing so, we revealed an overexpression of X-linked genes in the germline stem cells (GSCs) and were able to pinpoint the onset of meiotic silencing of the X chromosome in the spermatogonia/primary spermatocytes. This study provides a comprehensive dataset to identify genes expressed at specific stages of spermatogenesis, widening the toolkit for genetic control of malaria mosquitoes.
Establishment and Analysis of a Prognostic Model of Pancreatic Ductal Adenocarcinomas Based on Nerve-Cancer Crosstalk-related Genes
Authors: Jiang Lei , Lu Xiaozhi , Jiang Kuirong , Miao Yi , Yu Jun , Yin Lingdi , Wei Jishu 
Published: April 2023

Abstract
Background
Pancreatic ductal adenocarcinoma（PDAC）is the seventh leading cause of cancer-related death globally. It has an extremely poor prognosis, and its incidence rate and mortality are considered to increase sharply over the next few years. Combined chemotherapy after surgery is still the best treatment, and it is also the only curative option. Improvements in the understanding of genetic mutations, the tumor microenvironment (TME), and targeted therapies continue to improve the progression of PDAC. Nerves are an important component of the TME of pancreatic cancer. However, the role of cancer-nerve crosstalk-related genes in PDAC is still unclear.
Results
In our study, we constructed a prognostic model based on cancer-nerve crosstalk-related genes with prognostic value. The xCell algorithm was used to analyse the cell component enriched from samples in The Cancer Genome Atlas (TCGA) PDAC cohort. We found the neuronal content was significantly correlated with prognosis. Protein-protein interaction (PPI) network, GO, and KEGG enrichment analyses were used to identify nerve-related genes in PDAC. From the forty-two nerve-cancer crosstalk genes, we used K-M plotter to identify the canditate genes for LASSO regression. We constructed a three-gene prognostic model (CHRNB2, CHRNA10, NGFR). The model could effectively test and verify its 1-, 3- and 5-year survival rates in the TCGA-PDAC cohort. The effectiveness of the model was verified by external test data. The genes of this model were highly related to tumor progression and other immune microenvironments.
Conclusion
In summary, we used bioinformatics analysis to construct an effective prognostic model, explored the key mechanism of nerve-cancer cross-talk and revealed the potential of cancer-nerve cross-talk-related genes as prognostic biomarkers and therapeutic targets in PDAC.
Early antiretroviral therapy favors post-treatment SIV control associated with expansion of enhanced memory CD8+ T cells. pVISCONTI study
Authors: Saez-Cirion Asier , Passaes Caroline , Desjardins Delphine , Chapel Anais , Monceaux Valérie , Lemaitre Julien , Melard Adeline , Avettand-Fenoel Veronique , Perdomo-Celis Federico , Müller-Trutwin Michaela , Mouquet Hugo , Planchais Cyril , David Annie , Grand Roger Le , Dimant Nastasia , Bosquet Nathalie , Barrail-Tran Aurélie , Gouget Hélène , Guillaume Céline , Relouzat Francis , Lambotte Olivier , Guedj Jeremie , Rouzioux Christine 
Published: April 2023

Abstract
Post-treatment HIV controllers (PTCs) offer evidence that HIV remission can be achieved in some people after antiretroviral treatment (ART) discontinuation. However, the circumstances and mechanisms leading to PTC remain unclear. We evaluated the impact of early (week 4) vs late (week 24 post infection) ART initiation in SIVmac251-infected cynomolgus macaques that received 2 years of ART before analytical interruption (ATI). Early ART strongly promoted PTC. The divergent outcome of early and late-treated macaques was not related to differences in the frequency of infected cells at ATI. Rather, early treatment favored the development of long-term memory CD8+ T cells with enhanced proliferative and SIV suppressive capacity that were able to mediate a robust secondary-like response upon viral rebound. Our model allowed to formally demonstrate a link between ART initiation during primary infection and the promotion of post-treatment control and provided results that may guide the development of new immunotherapies seeking-HIV remission.
Scalable fabrication of gap-plasmon-based dynamic and chromogenic nanostructures by capillary-interaction driven self-assembly of liquid-metal
Authors: Gupta Tapajyoti Das , Sahu Renu Raman , Ramasamy Alwar Samy , S Santosh Bhonsle , C Mark Vailshery D 
Published: April 2023

Abstract
Dynamically tunable nanoengineered structures for coloration show promising applications in sensing, displays, and communication. However, their potential challenge remains in having a scalable manufacturing process over large scales in 10s of cm of area. For the first time, we report a novel approach for fabricating chromogenic nanostructures that respond to mechanical stimuli by utilizing the fluidic properties of polydimethylsiloxane (PDMS) as a substrate and the interfacial tension of liquid metal-based plasmonic nanoparticles. Relying on the PDMS tunable property and a physical deposition method, our approach is single-step, scalable, and does not rely on high carbon footprint lithographic processes. By tuning the oligomer content in PDMS, we show that varieties of structural colors covering a significant gamut in CIE coordinates are achieved. We develop a model which depicts the formation of Ga nanodroplets from the capillary interaction of oligomers in PDMS with Ga. We showcase the capabilities of our processing technique by presenting prototypes of reflective displays and sensors for monitoring body parts, smart bandages, and the capacity of the nanostructured film to map force in real-time. These examples illustrate this technology’s broad range of applications, such as large-area displays, devices for human-computer interactions, healthcare, and visual communication.
Multimode Design and Analysis of an Integrated Leg-Arm Quadruped Robot with Deployable Characteristics
Authors: Zhao Fu-Qun , Wu Yi-Fan , Yang Xin-Hua , Ding Xi-Lun , Xu Kun , Guo Sheng , Jin Xiao-Dong 
Published: April 2023

Abstract
To improve locomotion and operation integration, this paper presents an integrated leg-arm quadruped robot (ILQR) that has a reconfigurable joint. First, the reconfigurable joint is designed and assembled at the end of the leg-arm chain. When the robot performs a task, reconfigurable configuration and mode switching can be achieved using this joint. In contrast from traditional quadruped robots, this robot can stack in a designated area to optimize the occupied volume in a nonworking state. Kinematics modeling and dynamics modeling are established to evaluate the mechanical properties for multiple modes. All working modes of the robot are classified, which can be defined as deployable mode, locomotion mode and operation mode. Based on the stability margin and mechanical modeling, switching analysis and evaluation between each mode is carried out. Finally, the prototype experimental results verify the function realization and switching stability of multimode and provide a design method to integrate and perform multimode for quadruped robots with deployable characteristics.