bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nutritional status of children affected by X‐linked adrenoleukodystrophy
Authors: Moroni Isabella , De Amicis Ramona , Ardissone Anna , Ravella Simone , Bertoli Simona 
Published: March 2023

AbstractBackgroundAdrenoleukodystrophy (ALD) is a rare X‐linked metabolic disorder that causes the accumulation of very‐long‐chain fatty acids (VLCFAs) (C26:0) and the subsequent variety of clinical and neurological symptoms. Little is known about nutritional status and dietary habits of children affected by ALD, and so the present study aimed to assess nutritional status and food intake in children with ALD, also exploring the relationship between food intake and the consumption of disease‐specific dietary supplements to reduce blood C26:0 concentrations and increase monounsaturated fatty acids (C26:1).MethodsAll patients underwent a clinical and neurological evaluation and a comprehensive nutritional assessment. The association of VLCFA concentrations with dietary lipids was assessed.ResultsNine boys (11.49 ± 3.61 years) were enrolled in a cross‐sectional study. All patients were normal weight, with normal resting energy expenditure. Only six of nine patients followed the low‐fat diet and dietary supplements. An inverse association was found between the food intake of polyunsaturated lipids and C26:0; conversely, the C26:0 was positively associated with the dietary saturated lipids. When consumed, dietary supplement consumption correlated positively with C26:1 (ρ = 0.917, p = 0.029) and no correlation was found with C26:0 (ρ = 0.410, p = 0,493).ConclusionsNo children were found to be malnourished or overweight or obese; however, half of the children reported excessive body fat, probably as a result of the pharmacotherapies. A low‐fat diet could be adjuvant in the management of the accumulation of VLCFAs, but poor dietary compliance to disease‐specific nutritional guidelines appears to be a major problem of this condition and underlines the need for a structured and personalised nutritional management in ALD disease.
Is COVID Revealing a Virus in CMBS 2.0?
Authors: GRIFFIN JOHN M. , PRIEST ALEX 
Published: March 2023

ABSTRACTCommercial loan valuations crucially depend on accurate loan income, but underwritten income on commercial mortgage‐backed securities (CMBS) loans is commonly overstated relative to actual property income. Consistent with these differences being originator‐specific, income overstatement in CMBS 2.0 deals varies widely and persistently across originators, is priced by originators, is related across property types within an originator, is predictable ex ante, and is accompanied by inflation of past financials. Risk retention and associated regulation had no discernible effect on income overstatement. Originator income overstatement is highly predictive of pre‐ and COVID‐period loan distress. Overall, recent market stresses reveal large systemic differences in underwriting standards across originators.
Association between adolescents' socioeconomic status and working memory updating functioning: Role of parental educational involvement
Authors: Zhao Xin , Cao Wenjing , Maes Joseph H. R. 
Published: March 2023

AbstractFamily socioeconomic status (SES) is positively associated with executive functioning. This study tested whether parental educational involvement mediates this association. Two hundred and sixty, 12‐15‐year‐old adolescents completed working memory updating (WMU) and general intelligence tasks, and questionnaires on SES and parental educational involvement. SES and WMU ability were positively associated; there was no difference between the fathers and mothers for three types of educational involvement. The mothers’ behavioural involvement positively mediated the SES‐WM updating association, whereas a negative mediation was observed for the mothers’ intellectual involvement. The fathers’ educational involvement did not play a significant mediating role. These results might inform interventions targeting educational involvement for enhancing the cognitive development of children from low SES families.
Unemployment benefit eligibility requirements and perceived time pressure
Authors: Gerards Ruud , Welters Riccardo 
Published: March 2023

AbstractObjectivesAn emerging body of literature links stressors or obstacles (e.g., compliance to an unemployment benefit eligibility requirement) to poor job search quality, questioning the effectiveness of such requirements in helping the unemployed to find employment. We investigate whether compliance to an unemployment benefit eligibility requirement affects an unemployed person's perception of time pressure, which theory relates to job search quality and which itself is hard to gauge.MethodsWe conduct a propensity‐score matching analysis, using data on the Australian “mutual obligations” program, matching otherwise similar unemployed persons with and without an unemployment benefit eligibility requirement.ResultsControlling for a wide range of confounders, we find a statistically significant positive effect of an unemployment benefit eligibility requirement on the affected person's perception of time pressure as theory predicts.ConclusionsOthers have hypothesized that poor labor market outcomes for those subjected to a “mutual obligations” requirement are a result of the requirement's adverse effect on job search quality. Our finding that compliance to unemployment benefit eligibility requirements increases an unemployed person's perceptions of time pressure aligns with that hypothesis.
Associations between ABO non‐identical platelet transfusions and patient outcomes—A multicenter retrospective analysis
Authors: Bougie Daniel W. , Reese Sarah E. , Birch Rebecca J. , Bookwalter Deborah B. , Mitchell Patrick K. , Roh David , Kreuziger Lisa Baumann , Cable Ritchard G. , Goel Ruchika , Gottschall Jerome , Hauser Ronald George , Hendrickson Jeanne E. , Hod Eldad A. , Josephson Cassandra D. , Kahn Stacie , Kleinman Steven H. , Mast Alan E. , Ness Paul M. , Roubinian Nareg H. , Sloan Steven ,   for the NHLBI Recipient Epidemiology and Donor Evaluation Study‐IV‐Pediatric (REDS‐IV‐P)
Published: March 2023

AbstractBackgroundDue to platelet availability limitations, platelet units ABO mismatched to recipients are often transfused. However, since platelets express ABO antigens and are collected in plasma which may contain ABO isohemagglutinins, it remains controversial as to whether ABO non‐identical platelet transfusions could potentially pose harm and/or have reduced efficacy.Study Design and MethodsThe large 4‐year publicly available Recipient Epidemiology and Donor Evaluation Study‐III (REDS‐III) database was used to investigate patient outcomes associated with ABO non‐identical platelet transfusions. Outcomes included mortality, sepsis, and subsequent platelet transfusion requirements.ResultsFollowing adjustment for possible confounding factors, no statistically significant association between ABO non‐identical platelet transfusion and increased risk of mortality was observed in the overall cohort of 21,176 recipients. However, when analyzed by diagnostic category and recipient ABO group, associations with increased mortality for major mismatched transfusions were noted in two of eight subpopulations. Hematology/Oncology blood group A and B recipients (but not group O) showed a Hazard Ratio (HR) of 1.29 (95%CI: 1.03–1.62) and intracerebral hemorrhage group O recipients (but not groups A and B) showed a HR of 1.75 (95%CI: 1.10–2.80). Major mismatched transfusions were associated with increased odds of receiving additional platelet transfusion each post‐transfusion day (through day 5) regardless of the recipient blood group.DiscussionWe suggest that prospective studies are needed to determine if specific patient populations would benefit from receiving ABO identical platelet units. Our findings indicate that ABO‐identical platelet products minimize patient exposure to additional platelet doses.
Effectiveness of auricular acupoint therapy targeting menstrual pain for primary dysmenorrhea: A systematic review and meta‐analysis of randomized controlled trials
Authors: Cao Mengyao , Ye Fen , Xie Wenxuan , Yan Xinyi , Ho Mu‐Hsing , Cheung Denise Shuk Ting , Lee Jung Jae 
Published: March 2023

AbstractBackgroundPrimary dysmenorrhea (PD) is a global public health concern affecting women's health and quality of life, leading to productivity loss and increased medical expenses. As a non‐pharmacological intervention, auricular acupoint therapy (AAT) has been increasingly applied to treat PD, but the overall effectiveness remains unclear.AimsThe aim of this review was to synthesize the effects of AAT targeting menstrual pain among females with PD.MethodsEight databases (PubMed, EMBASE, AMED, CINAHL Plus, Cochrane Library, Web of Science, China National Knowledge Infrastructure and Wanfang Data) and three registries (ClinicalTrials.gov, ISRCTN Registry and the Chinese Clinical Trial Registry) were searched to identify existing randomized controlled trials (RCTs) from inception to 21 August 2022. Two reviewers independently screened, extracted the data, and appraised the methodological quality and the evidence strength using the Cochrane risk‐of‐bias tool for randomized trials (RoB 2) and the GRADE approach.ResultsA total of 793 participants from 11 RCTs were included. Despite substantial heterogeneity, AAT was more effective in reducing menstrual pain and related symptoms than placebo and nonsteroidal anti‐inflammatory medications (NSAIDs). No significant subgroup differences were found between study locations as well as invasiveness, duration, type, acupoints number, ear selection and provider of AAT. Only minor adverse effects of AAT were reported.Linking Evidence to ActionAAT can help women with PD, particularly those who are refrained from pharmaceuticals. Primary healthcare professionals, including nurses, can be well‐equipped to provide evidence‐based and effective AAT for people with PD. AAT can be used in a broader global clinical community. To provide an optimal effect and have wider usability, a unified practice standard is required, which would necessitate further adaptation of clinical care of people with PD. AAT effectively decreased menstrual pain and other accompanying symptoms of PD. More research is needed to identify effective AAT features and explore optimal therapy regimes for PD.
COMPLEX IDENTITY: GENES TO GOD
Authors: Love Carolyn J. 
Published: March 2023

AbstractUnraveling the complex notion of “self” and “other” necessitates a layered approach that explores biology, namely genetics; philosophy, namely event phenomenology; and culture, namely religion. This essay examines (1) the latest paradigm shift occurring in the genetic sciences due to the increased knowledge of epigenetic effects on gene expression and how our DNA functions in concert with the cellular apparatus, the body, and the environment; (2) the incorporation of relationality into a philosophical understanding of self; and (3) finally, what religion adds to this exploration of self. Thus, providing a glimpse at how these different approaches to identity help us understand the “self.”
A pnh-Adaptive Refinement Procedure for Numerical Optimal Control Problems
Authors: Bartali Lorenzo , Gabiccini Marco , Guiggiani Massimo 
Published: March 2023

Abstract
This paper presents an automatic procedure to enhance the accuracy of the numerical solution of an optimal control problem (OCP) discretized via direct collocation at Gauss–Legendre points. First, a numerical solution is obtained by solving a nonlinear program (NLP). Then, the method evaluates its accuracy and adaptively changes both the degree of the approximating polynomial within each mesh interval and the number of mesh intervals until a prescribed accuracy is met. The number of mesh intervals is increased for all state vector components alike, in a classical fashion. Instead, improving on state-of-the-art procedures, the degrees of the polynomials approximating the different components of the state vector are allowed to assume, in each finite element, distinct values. This explains the pnh definition, where n is the state dimension. With respect to the approaches found in the literature, where the degree is always raised to the highest order for all the state components, our methods allow a sensible reduction of the overall number of variables of the resulting NLP, with a corresponding reduction of the computational burden. Numerical tests on three OCP problems highlight that, under the same maximum allowable error, by independently selecting the degree of the polynomial for each state, our method effectively picks lower degrees for some of the states, thus reducing the overall number of variables in the NLP. Accordingly, various advantages are brought about, the most remarkable being: (i) an increased computational efficiency for the final enhanced mesh with solution accuracy still within the prescribed tolerance, (ii) a reduced risk of being trapped by local minima due to the reduced NLP size, and (iii) a gain of the robustness of the convergence process due to the better-behaved solution landscapes.
Assessment of the Impeller/Volute Relationship of Centrifugal Fans From an Aerodynamic and Aeroacoustic Perspective
Authors: Biedermann Till M. , Moutamassik Y. , Kameier F. 
Published: March 2023

Abstract
Heavy-duty centrifugal fans require high reliability and first-class performance. Besides, extreme conditions and harsh environments are often encountered, such as in the papermaking process, in steel or cement plants or the chemical and petrochemical industry. Therefore, the design of high-performance heavy-duty industrial fans requires robust yet efficient solutions. The previous work indicates a high aerodynamic and aeroacoustic sensitivity concerning the specific position of the volute cutoff (tongue). This effect will be further investigated, not by directly changing the orientation of the cutoff, but by varying the position of the impeller relative to a fixed volute casing. The initial evaluation is done through a numerical study of three influencing parameters, which allow the aerodynamic dependencies to be modeled using low-layer artificial networks. Subsequently, extensive experimental studies were carried out to validate the aerodynamic dependencies and also to incorporate information on the aeroacoustic performance. The obtained results show that the operating point represents the key factor in determining the optimal positioning, with qualitatively comparable dependencies found for both tested fans. From an aeroacoustic point of view, the determined optimal configuration does not necessarily coincide with the observed aerodynamic desires, so careful analysis and a reasonable compromise are required, motivating for a multi-objective optimization process.
Supplemental Material: Explanations of seismic data acquisition, processing, and interpretation. Time-thickness map and seismic cross-sections of Lower Cretaceous Mississippi Salt Basin. Methodology of salt tectonics physical models, landscape, and stratigraphic numerical models. Table with input parameters for landscape and stratigraphic numerical model. Figure illustrating uplift and subsidence rates of the sink domain. Explanations for animations.
Authors: Zhang Jinyu , al. et 
Published: March 2023

<p> Explanations of seismic data acquisition, processing, and interpretation. Time-thickness map and seismic cross-sections of Lower Cretaceous Mississippi Salt Basin. Methodology of salt tectonics physical models, landscape, and stratigraphic numerical models. Table with input parameters for landscape and stratigraphic numerical model. Figure illustrating uplift and subsidence rates of the sink domain. Explanations for animations. </p>
Health-related quality of life in adults born extremely preterm or with extremely low birth weight in the postsurfactant era: a longitudinal cohort study
Authors: Selman Christopher , Mainzer Rheanna , Lee Katherine , Anderson Peter , Burnett Alice , Garland Suzanne M , Patton George C , Pigdon Lauren , Roberts Gehan , Wark John , Doyle Lex W , Cheong Jeanie Ling Yoong 
Published: March 2023

ObjectivesTo compare health-related quality of life (HRQoL) at 25 and 18 years in individuals born extremely preterm (EP, <28 weeks’ gestation) or with extremely low birth weight (ELBW, birth weight <1000 g) with term-born (≥37 weeks) controls. Within the EP/ELBW cohort, to determine whether HRQoL differed between those with lower and higher IQs.MethodsHRQoL was self-reported using the Health Utilities Index Mark 3 (HUI3) at 18 and 25 years by 297 EP/ELBW and 251 controls born in 1991–1992 in Victoria, Australia. Median differences (MDs) between groups were estimated using multiple imputation to handle missing data.ResultsAdults born EP/ELBW had lower HRQoL (median utility 0.89) at 25 years than controls (median utility 0.93, MD −0.040), but with substantial uncertainty in the estimate (95% CI −0.088 to 0.008) and a smaller reduction at 18 years (MD −0.016, 95% CI –0.061 to 0.029). On individual HUI3 items, there was suboptimal performance on speech (OR 9.28, 95% CI 3.09 to 27.93) and dexterity (OR 5.44, 95% CI 1.04 to 28.45) in the EP/ELBW cohort. Within the EP/ELBW cohort, individuals with lower IQ had lower HRQoL compared with those with higher IQ at 25 (MD −0.031, 95% CI −0.126 to 0.064) and 18 years (MD −0.034, 95% CI −0.107 to 0.040), but again with substantial uncertainty in the estimates.ConclusionsCompared with term-born controls, young adults born EP/ELBW reported poorer HRQoL, as did those with lower IQ compared with those with higher IQ in the EP/ELBW cohort. Given the uncertainties, our findings need corroboration.
Multimedia Technology Based Interactive Translation Learning for Students
Authors: Wang Zhiguo , Na Hongwei 
Published: March 2023

Multimedia technology incorporates into the educational arena to translate traditional educational material into interactive digital mode. This has permitted teachers into the learning environment to design and integrate interactive multimedia learning. Many problems towards giving more attention to students facing teacher's multimedia levels are uneven, and their integration significance, bringing enormous curriculum learning strategies, is not entirely apparent. This research introduces multimedia network interpretation teaching using machine learning (MNIT-ML)in multimedia education design to enhance and strengthen the traditional teaching process and promote various modern approaches to transmit knowledge towards students.Allocation of learning resources (ALR) framework is mainly to enlarge the use and utilization of materials for learning activities from impressed resources into recordings, video content, motion graphics, and other forms of resources. The purpose of the Allocation of Learning Resources (ALR) framework is to aid teachers in making sound decisions about how to distribute available educational materials. Its goal is to guide teachers in making smart choices about how to use limited resources like time, money, and technology in order to improve students' educational achievements.
The ALR framework was picked because it offers a methodical strategy for selecting choices that is founded in educational research and best practices. Resource allocation is a key aspect in influencing student outcomes, and efficient allocation can help guarantee that all students have access to the tools they need to succeed.
There are a number of alternative frameworks that might direct studies on the distribution of educational resources. The Technological Acceptance Model (TAM) is a common tool for analysing what factors lead to widespread implementation of educational technology.
The goal of other frameworks like the Universal Design for Learning (UDL) framework is to help educators create lessons and methods that are inclusive of students of all backgrounds and abilities.
The final decision on which framework to use will be determined by the nature of the research issues and the setting in which they are being investigated. In order to make educated decisions, it is crucial to pick a framework that is appropriate for the research issues at hand and that gives a systematic approach based on established educational best practices. The digital promoting resources for teaching (DPRT) method creates a real environment for students to learn, focusing on enhancing training to make students feel the standard language translation skills. The simulation analysis is performed based on security 94.6%, the performance of 95.9%, and privacy, proving the proposed framework's reliability overall ratio of 93.4%.
Existence and Nonexistence of Positive Solutions for a Weighted Quasilinear Elliptic System
Authors: Hamzaoui Yamina , Matallah Atika , Ould El Mokhtar Mohammed El Mokhtar 
Published: March 2023

This paper deals with the existence and nonexistence of solutions for the following weighted quasilinear elliptic system,

S

μ

1

,

μ

2

q

1

,

q

2

−
div

q

1

x

∇
u

p
−
2

∇
u

=

μ

1

u

p
−
2

u
+

α
+
1

u

α
−
1

u

v

β
+
1

in
Ω

−
div

q

2

x

∇
v

p
−
2

∇
v

=

μ

2

v

p
−
2

v
+

β
+
1

u

α
+
1

v

β
−
1

v

in
Ω

u
>
0
,

v
>
0

in
Ω

u
=
v
=
0

on
∂
Ω

,

where

Ω
⊂

ℜ

N

N
≥
3

,
2
≤
p
<
N

,

q

1

,

q

2

∈

W

1
,
p

Ω

∩
C

Ω
¯

,

α
,
β
≥
0

,

μ

1

,

μ

2

,

≥
0

and

α
,
β
>
0

satisfy

α
+
β
=

p

∗

−
2

with

p

∗

=

p
N

/

N
−
p

is the critical Sobolev exponent. By means of variational methods we prove the existence of positive solutions which depends on the behavior of the weights

q

1

,

q

2

near their minima and the dimension

N

. Moreover, we use the well known Pohozaev identity for prove the nonexistence result.
Stroke After SARS-CoV-2 mRNA Vaccine: A Nationwide Registry Study
Authors: Ihle-Hansen Håkon , Bøås Håkon , Tapia German , Hagberg Guri , Ihle-Hansen Hege , Berild Jacob Dag , Selmer Randi , Karlstad Øystein , Gulseth Hanne Løvdal , Ariansen Inger 
Published: March 2023

Background:
Whether the SARS-CoV-2 mRNA vaccines may cause a transient increased stroke risk is uncertain.

Methods:
In a registry-based cohort of all adult residents at December 27, 2020, in Norway, we linked individual-level data on COVID-19 vaccination, positive SARS-CoV-2 test, hospital admissions, cause of death, health care worker status, and nursing home resident status extracted from the Emergency Preparedness Register for COVID-19 in Norway. The cohort was followed for incident intracerebral bleeding, ischemic stroke, and subarachnoid hemorrhage within the first 28 days after the first/second or third dose of mRNA vaccination until January 24, 2022. Stroke risk after vaccination relative to time not exposed to vaccination was assessed by Cox proportional hazard ratio, adjusted for age, sex, risk groups, health care personnel, and nursing home resident.

Results:
The cohort included 4 139 888 people, 49.8% women, and 6.7% were ≥80 years of age. During the first 28 days after an mRNA vaccine, 2104 people experienced a stroke (82% ischemic stroke, 13% intracerebral hemorrhage, and 5% subarachnoid hemorrhage). Adjusted hazard ratios (95% CI) after the first/second and after the third mRNA vaccine doses were 0.92 (0.85–1.00) and 0.89 (0.73–1.08) for ischemic stroke, 0.81 (0.67–0.98) and 1.05 (0.64–1.71) for intracerebral hemorrhage, and 0.64 (0.46–0.87) and 1.12 (0.57–2.19) for subarachnoid hemorrhage, respectively.

Conclusions:
We did not find increased risk of stroke during the first 28 days after an mRNA SARS-CoV-2 vaccine.