bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Pilot Study of Adolescents with Psychotic Experiences: Potential Cerebellar Circuitry Disruption Early Along the Psychosis Spectrum
Authors: Gaughan Caoimhe , Nasa Anurag , Roman Elena , Cullinane Dearbhla , Kelly Linda , Riaz Sahar , Brady Conan , Browne Ciaran , Sooknarine Vitallia , Mosley Olivia , Almulla Ahmad , Alsehli Assael , Kelliher Allison , Murphy Cian , O’Hanlon Erik , Cannon Mary , Roddy Darren William 
Published: June 2023

AbstractA
berrant connectivity in the cerebellum has been found in psychotic conditions such as schizophrenia corresponding with cognitive and motor deficits found in these conditions. Diffusion differences in the superior cerebellar peduncles, the white matter connecting the cerebellar circuitry to the rest of the brain, have also been found in schizophrenia and high-risk states. However, white matter diffusivity in the peduncles in individuals with sub-threshold psychotic experiences (PEs) but not reaching the threshold for a definitive diagnosis remains unstudied. This study investigates the cerebellar peduncles in adolescents with PEs but no formal psychiatric diagnosis.Sixteen adolescents with PEs and 17 age-matched controls recruited from schools underwent High-Angular-Resolution-Diffusion neuroimaging. Following constrained spherical deconvolution whole-brain tractography, the superior, inferior and middle peduncles were isolated and virtually dissected out using ExploreDTI. Differences for macroscopic and microscopic tract metrics were calculated using one-way between-group analyses of covariance controlling for age, sex and estimated Total Intracranial Volume (eTIV). Multiple comparisons were corrected using Bonferroni correction.A decrease in fractional anisotropy was identified in the right (p = 0.045) and left (p = 0.058) superior cerebellar peduncle; however, this did not survive strict Bonferroni multiple comparison correction. There were no differences in volumes or other diffusion metrics in either the middle or inferior peduncles.Our trend level changes in the superior cerebellar peduncle in a non-clinical sample exhibiting psychotic experiences complement similar but more profound changes previously found in ultra-high-risk individuals and those with psychotic disorders. This suggests that superior cerebellar peduncle circuitry perturbations may occur early along in the psychosis spectrum.
Anti-Inflammatory, Antioxidant, Metabolic and Gut Microbiota Modulation Activities of Probiotic in Cardiac Remodeling Condition: Evidence from Systematic Study and Meta-Analysis of Randomized Controlled Trials
Authors: Taslim Nurpudji Astuti , Yusuf Muhammad , Ambari Ade Meidian , Del Rosario Puling Imke Maria , Ibrahim Filzatuz Zahro , Hardinsyah Hardinsyah , Kurniawan Rudy , Gunawan William Ben , Mayulu Nelly , Joseph Victor F. F. , Sabrina Nindy , Rizal Mochammad , Tallei Trina Ekawati , Kim Bonglee , Tsopmo Apollinaire , Nurkolis Fahrul 
Published: June 2023

AbstractHeart failure (HF) is a global pandemic with increasing prevalence and mortality rates annually. Its main cause is myocardial infarction (MI), followed by rapid cardiac remodeling. Several clinical studies have shown that probiotics can improve the quality of life and reduce cardiovascular risk factors. This systematic review and meta-analysis aimed to investigate the effectiveness of probiotics in preventing HF caused by a MI according to a prospectively registered protocol (PROSPERO: CRD42023388870). Four independent evaluators independently extracted the data using predefined extraction forms and evaluated the eligibility and accuracy of the studies. A total of six studies consisting of 366 participants were included in the systematic review. Probiotics are not significant in intervening left ventricular ejection fraction (LVEF) and high-sensitivity C-reactive protein (hs-CRP) when compared between the intervention group and the control group due to inadequate studies supporting its efficacy. Among sarcopenia indexes, hand grip strength (HGS) showed robust correlations with the Wnt biomarkers (p < 0.05), improved short physical performance battery (SPPB) scores were also strongly correlated with Dickkopf-related protein (Dkk)-3, followed by Dkk-1, and sterol regulatory element-binding protein 1 (SREBP-1) (p < 0.05). The probiotic group showed improvement in total cholesterol (p = 0.01) and uric acid (p = 0.014) compared to the baseline. Finally, probiotic supplements may be an anti-inflammatory, antioxidant, metabolic, and intestinal microbiota modulator in cardiac remodeling conditions. Probiotics have great potential to attenuate cardiac remodeling in HF or post-MI patients while also enhancing the Wnt signaling pathway which can improve sarcopenia under such conditions.
Progress and prospects in research and clinical practice of hormone receptor-positive, HER-2-negative breast cancer with BRCA1/2 mutations
Authors: Yan Shunchao , Imam Murshid 
Published: June 2023

AbstractBreast cancer (BC) is a heterogeneous disease that is the most common cancer in women worldwide. However, precise subtyping and corresponding treatments have improved patient outcomes. Hormone receptor (HR)-positive, human epidermal growth factor receptor type 2 (HER2)-negative (HR+/HER2-) BC with BRCA1 and/or BRCA2 mutations (BRCA1/2m) is a unique BC subset with dual drivers: homologous recombination deficiency and hormone receptor signaling. Wild-type BRCA1/2 suppresses estrogen receptor-mediated signaling. Loss-of-function mutations in BRCA1/2 release estrogen receptor suppression, leading to reduced sensitivity to endocrine therapy. Poly (ADP-ribose) polymerase (PARP) inhibitors (PARPis) exert antitumor effects against this subtype and can be used in combination with endocrine therapy. Although PARPis have been evaluated in metastatic triple-negative breast cancer, their efficacy against HR+/HER2- BC has not been clearly established. The present review summarizes recent advances and prospects in the progress of the HR+/HER2-/BRCA1/2m subgroup. As such, this article provides theoretical guidance for future research and promotes the use of PARPis for the treatment of HR+/HER2-/BRCA1/2m BC.
Mixed Market Structure and R &D: A Differential Game Approach
Authors: Yanase Akihiko , Long Ngo Van 
Published: June 2023

AbstractWe consider a dynamic model of an industry consisting of a few large firms, which can manipulate the market outcome, and a mass of small enterprises, each of which has a negligible impact on the market. The production costs of the respective firms depend on the stock of knowledge capital, which accumulates over time through research and development (R &D) investment made by large firms. The model is a variant of the differential game of voluntary provision of public goods, but in contrast to previous studies, we focus on the interaction between market competition and dynamic game outcomes. We derive both open-loop and Markov-perfect Nash equilibria. There exists a unique open-loop Nash equilibrium. By contrast, depending on the parameters of the model, there can be two linear Markov-perfect Nash equilibria. We also examine the short- and long-run effects of a change in the number of large firms. An increase in the number of large firms unambiguously harms both types of firms in the short run but may benefit them in the long run. In the open-loop Nash equilibrium, the relationship between the number of large firms and the steady-state stock of knowledge capital is inverted-U shaped. Concerning the Markov-perfect Nash equilibria, the effect of increased competition from large firms depends on the specific feedback strategy chosen in equilibrium.
Annexin A9 promotes cell proliferation by regulating the Wnt signaling pathway in colorectal cancer
Authors: Lu Xuemei , Hu Liqiang , Mao Jiayan , Zhang Shufen , Cai Ying , Chen Wei 
Published: June 2023

AbstractColorectal cancer (CRC) is one of the leading causes of cancer-related mortality worldwide. Expression of Annexin A9 (ANXA9), a member of the annexin A family, is upregulated in CRC. However, the molecular role of ANXA9 in CRC remains unknown. In the present study, we aimed to investigate the function of ANXA9 and to elucidate the mechanisms underlying its regulation in CRC. In this study, mRNA expression data and clinical information were downloaded from The Cancer Genome Atlas (TCGA) and GEPIA database, respectively. Kaplan–Meier analysis was used to analyze the survival rates. LinkedOmics and Metascape databases were used to explore the potential mechanisms of regulation of ANXA9 and to identify genes co-expressed with ANXA9. Finally, in vitro experiments were used to evaluate the function of ANXA9 and explore potential mechanisms. We found that ANXA9 expression was significantly elevated in CRC tissue and cells. High ANXA9 expression was associated with shorter overall survival, poorer disease specific survival, as well as with patient age, clinical stage, M stage, and OS events in CRC. Knockdown of ANXA9 inhibited cell proliferation, invasion, migratory potential, and cell cycle arrest. Mechanistically, functional analysis revealed that genes co-expressed with ANXA9 were mainly enriched in the Wnt signaling pathway. ANXA9 deletion suppressed cell proliferation via the Wnt signaling pathway, while Wnt activation reversed the effects of ANXA9. In conclusion, ANXA9 may promote CRC progression by regulating the Wnt signaling pathway and may be a potential diagnostic biomarker in the clinical management of CRC.
Prospects for the transformation and development of carbon storage in abandoned mines of coal enterprises from the perspective of carbon neutrality
Authors: Lyu Xin , Zhang Tong , Yuan Liang , Fang Juejing 
Published: June 2023

AbstractUnder the carbon neutrality goal, coal enterprises must seek breakthroughs from abandoned mines, develop new resources in the new era, turn problems into countermeasures, and participate in the carbon emissions market, for contributing to the accomplishment of the national strategic goal of carbon neutrality. To this end, we investigated the relevant national policies and regulations to clarify the boundaries disclosed by the carbon information of enterprises, understood the development direction of carbon storage in abandoned mines, and clarified the transformation and development of carbon storage in abandoned mines. We made a few suggestions: (1) China should learn from its past experience and other countries to develop the energy industry with Chinese characteristics and reform the economic system. (2) Coal enterprises must actively respond to the national carbon information disclosure policy, clarify their own responsibilities and carbon emission boundaries. (3) It is necessary to proactively obtain advanced knowledge and plan carbon storage pathways for abandoned mines. (4) Development problems of coal enterprises should be deduced using cases. The ‘dual carbon’ goals should be achieved steadily step-by-step. (5) Three measures, i.e. improving the existing resource structure, coordinating the information of abandoned mines, and promoting the cultivation of scientific and technological talents.
Health care impact of implementing a clinical pathway for acute care of pediatric concussion: a stepped wedge, cluster randomised trial
Authors: Yeates Keith Owen , Barlow Karen M. , Wright Bruce , Tang Ken , Barrett Olesya , Berdusco Edward , Black Amanda M. , Clark Brenda , Conradi Alf , Godfrey Heather , Kolstad Ashley T. , Ly Anh , Mikrogianakis Angelo , Purser Ross , Schneider Kathryn , Stang Antonia S. , Zemek Roger , Zwicker Jennifer D. , Johnson David W. 
Published: June 2023

Abstract
Objectives
To test the effects of actively implementing a clinical pathway for acute care of pediatric concussion on health care utilization and costs.

Methods
Stepped wedge, cluster randomized trial of a clinical pathway, conducted in 5 emergency departments (ED) in Alberta, Canada from February 1 to November 30, 2019. The clinical pathway emphasized standardized assessment of risk for persistent symptoms, provision of consistent information to patients and families, and referral for outpatient follow-up. De-identified administrative data measured 6 outcomes: ED return visits; outpatient follow-up visits; length of ED stay, including total time, time from triage to physician initial assessment, and time from physician initial assessment to disposition; and total physician claims in an episode of care.

Results
A total of 2878 unique patients (1164 female, 1713 male) aged 5–17 years (median 11.00, IQR 8, 14) met case criteria. They completed 3009 visits to the 5 sites and 781 follow-up visits to outpatient care, constituting 2910 episodes of care. Implementation did not alter the likelihood of an ED return visit (OR 0.77, 95% CI 0.39, 1.52), but increased the likelihood of outpatient follow-up visits (OR 1.84, 95% CI 1.19, 2.85). Total length of ED stay was unchanged, but time from physician initial assessment to disposition decreased significantly (mean change − 23.76 min, 95% CI − 37.99, − 9.52). Total physician claims increased significantly at only 1 of 5 sites.

Conclusions
Implementation of a clinical pathway in the ED increased outpatient follow-up and reduced the time from physician initial assessment to disposition, without increasing physician costs. Implementation of a clinical pathway can align acute care of pediatric concussion more closely with existing clinical practice guidelines while making care more efficient.

Trial registration
ClinicalTrials.gov NCT05095012.
Investigating the evolution of gaseous air pollutants with prevailing meteorology across selected sites within a pollution hotspot in Ile-Ife, Southwestern Nigeria
Authors: Omokungbe Opeyemi R. , Olufemi Ayodele P. , Toyeje Adekunle B. , Abiodun Pelumi O. 
Published: June 2023

AbstractThis study investigates the evolution of gaseous pollutants with prevailing meteorology using a network of Alpha sense low-cost portable air monitoring devices deployed to six selected sampling sites namely the Iron steel smelting factory (ISSF), Modomo, Eleweran, Fire service station, staff quarters, and OAU Teaching and research farm (OAUTRF). All six sampling sites were chosen along the pollution hotspot in Ile-Ife. The low-cost sensor has Optical particle counters (OPC-N2) which measured particulate matter and the gaseous pollutants were monitored with electrochemical sensors. At the sites, each sensor unit measured gaseous pollutants: carbon dioxide (CO2), ozone (O3), carbon monoxide (CO), and oxides of nitrogen (NO and NO2). Inbuilt into the monitoring device are temperature and relative humidity (RH) probes as well as a 2-D sonic anemometer to measure wind speed and directions. The directional dependence of the local source of the gaseous pollutant affecting each site was determined using the conditional probability function (CPF) model. The results showed that the highest mean values of 470.6 ppm, 7.2 ppb, and 20.6 ppb for CO2, NO, and NO2, respectively were recorded at the Modomo site while ISSF and Fire service sites were found to have the highest mean values of 67.9 ppb and 517.6 ppb, respectively for O3and CO during the observational period. The mean values for temperature were noticed to increase in trend from OAUTRF (24.9 °C) to ISSF (26.0 °C). Also, CO2gave a good relationship with meteorological parameters with R2value ranging from 0.26 to 0.89 in all the sampling sites except ISSF. On contrary, weak relationships were found between the meteorological variables and other gaseous pollutants other than CO2for both day and nighttime periods. The CPF model indicated that a larger percentage of the elevated O3, NO and NO2were associated with pollutant transport at wind speed$$>2 m/s$$>2m/sdue to low event number. This study concludes that there is evidence of a significant effect of meteorological parameters on the gaseous pollutants as observed, while, the CPF plot shows a good agreement with the location of known pollution sources.
Two decades of mass-balance observations on Aldegondabreen, Spitsbergen: interannual variability and sensitivity to climate change
Authors: Terekhov Anton , Prokhorova Uliana , Verkulich Sergey , Demidov Vasiliy , Sidorova Olga , Anisimov Mikhail , Romashova Kseniia 
Published: June 2023

AbstractAldegondabreen is a relatively small (5.3 km2) land-terminating glacier located in Nordeskiöld Land of Svalbard, ~10 km southwest of Barentsburg. Cumulative mass balance during 2002–20 equalled −21.79 m w.e., which corresponds to 37% of the total mass loss. The annual mass balance (Ba) varied from −0.24 to −2.19 m w.e., while the winter mass balance (Bw) ranged between 0.36 and 0.85 m w.e. Ba and Bw were strongly correlated with the positive degree-day sums and solid precipitation amounts, respectively, measured at the Barentsburg weather station. There was also a strong correlation (r = 0.76) between Ba and Bw, which shows that winter accumulation amplifies the consecutive summer ice melt by changing the surface albedo. The trend in both observational series is not detectable because the period from 2005 to 2013 was characterized by relatively high Bw and not very negative Ba values. This was also observed on the other Svalbard glaciers, and was related to prevailing north-westerly flows over Svalbard during the summer. Therefore, the decadal periodicity of the Aldegondabreen mass balance follows general archipelago patterns that are determined by regional-scale factors. Thus, the surface mass-balance time series, which is now the longest one in the central part of the Spitsbergen Island, is representative for the archipelago.
Diagnostic stewardship for human immunodeficiency virus (HIV) testing using computerized physician order entry
Authors: Wilber Eli P. , Adhyaru Bhavin B. , Wang Yun F. , Sellars-Williams Celeste , Rebolledo Paulina A. 
Published: June 2023

Abstract
Altering the appearance of a computerized physician order entry (CPOE) interface reduces misuse of an HIV diagnostic test by 87%, demonstrating that CPOE design is a key component of diagnostic stewardship. Collaboration between infectious disease providers, clinical laboratorians, and information technology (IT) professionals can result in improved quality and decreased costs.
‘Our Classes Are Like Mainstream School Now’: Implementing Universal Design for Learning at a Special School
Authors: Cumming Therese M. , Gilanyi Lisa 
Published: June 2023

AbstractStudents with emotional and behavioural disability who receive their education in special settings often do not have access to the curriculum through evidence-based pedagogies, such as direct instruction, and instead complete packets of worksheets or participate in distance education. The current study was a collaborative action research project involving a special school for students with emotional disability and a local university to examine the effects of replacing online distance education with in-person direct instruction underpinned by Universal Design for Learning. Researchers sought to discover teacher and student perceptions of Universal Design for Learning, enablers and barriers to its implementation, and its effect on attendance and behaviour. Results suggested satisfaction on the part of both students and teachers and a positive effect of Universal Design for Learning on both attendance and behaviour.
A Fast Track to Social Rights? Passported Benefits and Administrative Burden
Authors: Tarshish Noam , Gal John , Holler Roni , Benish Avishai , Dahan Momi 
Published: June 2023

Abstract
Passported benefits are additional benefits provided to individual or households based on a previous eligibility to a “primary” social security benefit. Although passported benefits should be easier to claim, in reality the claiming process is often cumbersome and results in low take-up. Drawing on an Israeli case study, we offer a conceptual framework to categorize and analyse the varieties of passported benefits along five dimensions: the eligibility role of primary cash benefits; automation level; legal status; type of service delivery; and the degree of decentralization. The administrative burden literature is employed to make sense of the paradox of passported benefits becoming a site for administrative burden. Using our conceptual framework and drawing on interviews with officials and claimants, we demonstrate why some passported benefits are more user-friendly while others tend to become administratively burdensome.
Minimum required accuracy for HD maps
Authors: Křehlík Štěpán , Vanžura Marek , Skokan Adam 
Published: June 2023

AbstractAutonomous vehicles rely on a combination of sensors for safe navigation around the world. For precise localisation, high-definition (HD) maps are used. These maps are a representation of the world containing information about objects on the road infrastructure. Currently, there are tens of HD map makers, however, no rigorous description of the requirements for the accuracy of HD maps has been published yet. This study fills the gap and offers a mathematical description of the minimum required accuracy for HD maps. In the first part, we identify factors that influence the quality of a map. Based on that, we proceed to present our solution for determining the minimum required accuracy for HD maps, both for static and dynamic models, and present a new formula for the minimum necessary accuracy for HD maps.
Testing the temporal precedence of family functioning and child psychopathology in the LONGSCAN sample
Authors: Serna Ashley , Thakur Hena , Cohen Joseph R. , Briley D. A. 
Published: June 2023

AbstractFamily functioning may serve as protective or risk factors in the development of youth psychopathology. However, few studies have examined the potentially reciprocal relation between child psychopathology and family functioning. To fill this gap in the literature, this study tested for time-ordered associations between measures of family functioning (e.g., cohesion, conflict, and emotional expressiveness) and child psychopathology (e.g., total behavior problems, externalizing, and internalizing problems) using data from the Longitudinal Studies of Child Abuse and Neglect (LONGSCAN; N = 1143, 52.3% female, Nwaves = 5). We used a random-intercept cross-lagged panel model to identify whether child psychopathology preceded and predicted family functioning, the reverse, or both processes occurred simultaneously. At the between-person level, families who tended to have more cohesion, who lacked conflict, and who expressed their emotions had lower levels of child psychopathology. At the within-person level in childhood, we found minimal evidence for time-ordered associations. In adolescence, however, a clear pattern whereby early psychopathology consistently predicted subsequent family functioning emerged, and the reverse direction was rarely found. Results indicate a complex dynamic relation between the family unit and child that have important implications for developmental models that contextualize risk and resilience within the family unit.