bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimalisasi Penggunaan Website Newsroom dalam Meningkatkan Pelayanan Informasi Berbasis Elektronik
Authors: Tumija Tumija , Kafi Fadhilah 
Published: January 2025

Tujuan penelitian ini mendapatkan gambaran optimalisasi penggunaan website newsroom, hambatan dan upayanya untuk meningkatkan pelayanan berbasis elektronik di Kabupaten Bekasi. Metode dalam penelitian ini adalah deskriptif kualitatif. Teknik pengumpulan data yang digunakan adalah observasi, wawancara, dan dokumentasi. Adapun tehnik analisisis data yang digunakan adalah reduksi data, penyajian data, dan verifikasi data. Hasil penelitian menunjukkan bahwa penggunaan website newsroom dalam meningkatkan pelayanan informasi berbasis elektronik pada Dinas Komunikasi Informatika Persandian dan Statistik Kabupaten Bekasi sudah optimal. Hal tersebut sesui tiga dimensi optimalisasi yaitu tujuan, alternatif keputusan dan sumber daya sudah dilaksanakan dengan baik sesuai Peraturan Bupati Bekasi Nomor 128 Tahun 2020. Namun dalam kualitas layanan dimensi efisiensi pada indikator pengunjung website newsroom hanya 50,6% dari pelayanan masyarakat. Kemudian dimensi system availability pada indikator kondisi jaringan internet masih terbatas. Adapun beberapa faktor penghambat dalam penggunaan website newsroom yaitu kurangnya sosialisasi, keterbatasan jaringan internet di dua Kecamatan, dan keterbatasan media elektronik. Hal ini di sebabkan karena masih banyaknya masyarakat yang memiliki ekonomi rendah. Upaya yang dilakukan Dinas Komunikasi Informatika Persandian dan Statistik melakukan sosialisasi dan meningkatkan jaringan internet. Adapun sarannya yaitu sebaiknya meningkatkan sosialisasi pelayanan informasi berbasis elektronik.
Kata kunci: Optimalisasi, Newsroom, Pelayanan Informasi Berbasis Elektronik.
Penilaian Tata Kelola Teknologi Informasi Berbasis Kinerja Organisasi Menggunakan Cobit 2019 dan Balanced Scorecard (Studi pada Dinas Komunikasi, Informatika, Persandian, dan Statistik Kabupaten Kolaka Timur)
Authors: Wahyudi Reski , Murdiyana Murdiyana , Ikhbaluddin Ikhbaluddin 
Published: January 2025

Penelitian ini berangkat dari adanya beberapa fenomena penerapan Teknologi Informasi (TI) dalam pelayanan publik di Kabupaten Kolaka Timur, yang selanjutnya dirumuskan menjadi isu-isu strategis dalam Renstra sebagai upaya memberi solusi terhadap permasalahan tata kelola TI yang belum terintegrasi, kurangnya singkronisasi dan koordinasi perangkat daerah dalam membangun jaringan terintegrasi, kualitas SDM bidang TIK yang masih rendah, serta sarana prasarana TI yang belum memadai. Penelitian ini tertuju agar pengevaluasian peran tata kelola TI dalam meningkatkan kinerja organisasi pemerintahan, dengan fokus pada Dinas Komunikasi, Informatika, Persandian dan Statistik (Diskominfosantik) Kabupaten Kolaka Timur. Menggunakan pendekatan mixed method dengan desain eksploratori sekuensial, penelitian ini menggabungkan analisis kualitatif dengan validasi kuantitatif, pengumpulan data melalui wawancara dan kuesioner. Analisis dengan Balanced Scorecard mengungkapkan bahwa target kinerja yang berorientasi pada pelanggan tidak terpenuhi. Mengacu pada tujuan layanan pelanggan COBIT 2019, studi ini memetakan tata kelola TI di empat domain. Hasil penelitian menunjukkan domain APO02 (strategi terkelola) mencapai level 3, sedangkan APO03, BAI05, dan DSS06 mencapai level 2. rekomendasi berdasarkan kerangka kerja COBIT 2019 diberikan. Rekomendasinya adalah peningkatan tata kelola dan manajemen teknologi informasi, memastikan semua proses berfungsi penuh dan selaras dengan tujuan organisasi, dan mengikuti pedoman COBIT 2019 untuk meningkatkan praktik tata kelola TI supaya mendukung pencapaian tujuan strategis.

Kata kunci: Kinerja Organisasi, Tata Kelola Teknologi Informasi, Balanced Scorecard, COBIT 2019.
Research on detection methods of related substances and degradation products of the antitumor drug selpercatinib
Authors: Xiang Jingjing , Cai Liangliang , Wang Qin , Zhu Yonghong , Han Yong 
Published: January 2025

BackgroundSelpercatinib, a selective RET kinase inhibitor, is approved for treating various cancers with RET gene mutations such as RET-rearranged thyroid cancer and non-small cell lung cancer. The presence of process-related and degradation impurities in its active pharmaceutical ingredient (API) can significantly affect its safety and effectiveness. However, research on detecting these impurities is limited.MethodsThis study developed and systematically validated a High-Performance Liquid Chromatography (HPLC) method for identifying selpercatinib and its related impurities. The method utilized a 4.6 mm × 250 mm chromatographic column with 5 μm particles, employing a flow rate of 1.0 mL/min, a detection wavelength of 235 nm, an injection volume of 10 μL, and a column temperature of 35°C. Mobile phase A was composed of a 9:1 ratio of water to acetonitrile, with the aqueous component adjusted to pH 2.5 and containing 2 mM potassium dihydrogen phosphate (KH2PO4) and 0.4% triethylamine. Mobile phase B was pure acetonitrile. The gradient elution program was as follows: 0–2 min, 5%B; 2–15 min, 5% to 15%B; 15–30 min, 15% to 35%B; 30–35 min, 35% to 45%B; 35–36 min, 45% to 5%B; 36–45 min, 5%B.ResultsThe chromatographic method established in this study was validated according to the ICH Q2 (R1) guidelines. The developed HPLC method demonstrated excellent specificity, sensitivity, stability, linearity, precision, accuracy, and robustness. It efficiently separated the impurities present in selpercatinib, thereby confirming the method’s efficacy in ensuring the purity and quality of the drug.ConclusionThe chromatographic method established in this study can be used for the detection of selpercatinib and its impurities, providing significant reference value for the quality research of selpercatinib bulk drug and its preparations, and ensuring the safety of medication for patients.
Unsupervised machine learning model for phenogroup-based stratification in acute type A aortic dissection to identify postoperative acute gastrointestinal injury
Authors: Ma Yuhu , Yang Xiaofang , Weng Chenxiang , Wang Xiaoqing , Zhang Baoping , Liu Ying , Wang Rui , Bao Zhenxing , Yang Peining , Zhang Hong , Liu Yatao 
Published: January 2025

ObjectiveWe aimed to explore the application value of unsupervised machine learning in identifying acute gastrointestinal injury (AGI) after extracorporeal circulation for acute type A aortic dissection (ATAAD).MethodsPatients who underwent extracorporeal circulation for ATAAD at the First Hospital of Lanzhou University from January 2016 to January 2021 were included. Unsupervised machine learning algorithm was used to stratify patients into different phenogroups according to the similarity of their clinical features and laboratory test results. The differences in the incidence of perioperative AGI and other adverse events among different phenogroups were compared. Logistic regression was used to analyze the high-risk factors for AGI in each phenogroups and random forest (RF) algorithms were used to construct diagnostic models for AGI in different phenogroups.ResultsA total of 188 patients were included, with 166 males and 22 females. Unsupervised Machine Learning stratified patients into three phenogroups (phenogroup A, B, and C). Compared with other phenogroups, phenogroup B patients were older (P &lt; 0.01), had higher preoperative lactate and D-dimer levels, and had the highest incidence of AGI (52.5%, P &lt; 0.001) and in-hospital mortality (18.6%, P = 0.002). The random forest model showed that the top four risk factors for AGI in phenogroup B were cardiopulmonary bypass time, operation time, aortic clamping time, and ventilator time, which were significantly different from other phenogroups. The areas under the curve (AUCs) for diagnosing postoperative AGI of phenogroup A, B, and C were 0.943 (0.854–0.992), 0.990 (0.966–1.000), and 0.964 (0.899–0.997) using the RF model, respectively.ConclusionPhenogroup stratification based on unsupervised learning can accurately identify high-risk populations for postoperative AGI in ATAAD, providing a new approach for implementing individualized preventive and therapeutic measures in clinical practice.
Cardioneuroablation for reflex syncope or functional bradyarrhytmias: new insight from a single center experience
Authors: Valenti Noemi , Di Monaco Antonio , Romanazzi Imma , Vitulano Nicola , Troisi Federica , Quadrini Federico , Vitullo Antonio , Sgarra Luca , Caruso Rosa , Anzelmo Vincenzo , Guida Pietro , Brunetti Natale Daniele , Grimaldi Massimo 
Published: January 2025

BackgroundCardioneuroablation (CNA) is a new approach to treat reflex syncope and functional bradyarrhytmias caused by autonomic imbalance. We report our experience using CNA.MethodFrom September 2022 to July 2023, we took care of 21 patients (mean age 42 ± 21 years; 62% male) affected by reflex syncope or functional bradyarrhythmias. All patients underwent CNA under conscious sedation targeting the superior and/or inferior paraseptal ganglionated plexus (GPs).ResultsNine patients were affected by vasovagal syncope (VVS) and twelve by functional bradyarrhythmias. In 3 cases (14%) the ablation was performed only on the GPs of the right atrium, while in the remaining 86% of cases we performed biatrial lesions. As regards the acute results, we highlighted an increase in sinus heart rate (12 ± 15 bpm, p = 0.001), a shortening of the PQ interval (−18 ± 18 msec, p &lt; 0.001), a reduction of the correct sinus node recovery times (cSNRT) (−142 ± 204 msec, p = 0.114), a shortening of the AH interval (−31 ± 26 msec, p = 0.008), a reduction of the effective refractory period of the atrio-ventricular node (−156; interquartile range from −30 to −160 msec, p = 0.042) and an increase in the Wencheback point (27 ± 20 bpm, p &lt; 0.001). At follow-up, a single patient, due to persistent symptoms and bradyarrhythmic disorder, underwent permanent pacemaker implantation; no other patient had recurrence of syncope, and all remained persistently asymptomatic.ConclusionOur results confirm the efficacy and safety of CNA for the treatment of VVS and functional bradyarrhythmias, although further studies are needed to support these findings.
Support in digital health skill development for vulnerable groups in a public library setting: perspectives of trainers
Authors: Standaar Lucille M. B. , Israel Adriana M. C. , van der Vaart Rosalie , Keij Brigitta , Friele Roland D. , Beenackers Mariëlle A. , van Tuyl L. H. D. 
Published: January 2025

IntroductionThe digitalization of healthcare poses a risk of exacerbating health inequalities. Dutch public libraries offer freely accessible e-health courses given by trainers. However, there is limited knowledge on whether these libraries successfully reach and support those in need. This study aimed to explore trainers’ perspectives on the challenges, successes, and potential improvements in digital health skill education in a library setting.Materials and methodsTrainers of the e-health course were interviewed. Topics included: the role of the library in digital health skills education, the successes and challenges in reaching groups with a low socioeconomic position, the perceived impact of the digital health skills education, and strategies for future improvement in digital health skills education. A deductive analysis based upon the interview guide topics was performed. A second inductive analysis was applied to identify underlying patterns. Coding was done independently and cross-checked. Codebooks and themes were determined in discussion with authors.ResultsThree themes emerged. 1) Trainers’ services, skills and expertise: Trainers identified older adults, youth, people with low (digital) literacy, the unemployed, and people from non-native cultural backgrounds as the groups most in need of support. Trainers felt equipped to address these groups’ needs. 2) The libraries’ reach: improving engagement, perceived accessibility, and clients’ barriers: Despite trainers’ efforts to adjust the course to the target groups’ level of commitment, digital and literacy levels, and logistics, the digital health course predominantly engages older adults. Experienced barriers in reach: limited perceived accessibility of the public library and clients’ personal barriers. 3) Collaborations with healthcare, welfare and community organizations: Trainers emphasized that collaborations could enhance the diversity and number of participants. Current partnerships provided: reach to target groups, teaching locations, and referral of clients.DiscussionTrainers in public libraries recognize a various target groups that need support in digital health skill development. The study identified three challenges: accessibility of the digital health course, reach of the public library, and clients’ personal barriers. Public libraries have potential to support their target groups but need strategies to improve their engagement and reach. Collaborations with healthcare, welfare, and community organizations are essential to improve their reach to those most in need of support.
A comparative analysis of protected area expansion strategies for biodiversity and ecosystem services: a case study of Hainan Island
Authors: Wang Lijuan 
Published: January 2025

IntroductionThe allocation of limited resources to simultaneously protect biodiversity and provide ecosystem services (ESs) is a critical global challenge in achieving the Kunming–Montreal Global Biodiversity Framework. One common strategy for this challenge is to expand existing protected areas (PAs), but the efficiency of different expansion methods for biodiversity and ESs remains unknown.MethodsThis study investigated two strategies, preserving existing PAs (“locking”) versus reassessing their boundaries (“unlocking”), to evaluate their effectiveness in achieving biodiversity and ES targets. The study used Marxan, a spatial modeling tool, to assess the effectiveness of PAs expansion strategies on Hainan Island in China.Results and discussionThe current PAs system, which encompasses 8.82% of the island, is inadequate for protecting the target levels of biodiversity and ES. We experimented with expanding the PAs to 15% using both strategies. The results revealed that, compared with the “unlocking” strategy, the “locking” strategy favored ES protection (66.49% vs 86.84%), but did so at the expense of biodiversity conservation. In contrast, the “unlocking” strategy required a larger area for expansion and led to increased habitat fragmentation compared wtih the “locking” approach. These findings underscore the need for a strategic approach to expanding PAs and balancing between biodiversity conservation and ES provision. This study offers valuable insights that could be used for broader applications in PAs management and biodiversity conservation planning.
Alcohol intake exacerbates experimental autoimmune prostatitis through activating PI3K/AKT/mTOR pathway-mediated Th1 differentiation
Authors: Xu Shun , Chen Jing , Yue Shaoyu , Zhang Yifan , Zhao Shengyu , Hu Yongtao , Zhang Cheng , Guan Wenrui , Zhang Li , Zhang Ligang , Liang Chaozhao 
Published: January 2025

BackgroundEpidemiological investigations have revealed a significant association between alcohol consumption and chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). Nevertheless, the potential mechanisms are still inadequately revealed. This research aimed to investigate the impact of alcohol on CP/CPPS using an animal model and to elucidate the underlying mechanisms.MethodsWe first established the widely used animal model for CP/CPPS, experimental autoimmune prostatitis (EAP). During the induction of EAP, mice were fed with alcohol or control diet. The HE staining, ELISA, and behavioral experiments were employed to assess the severity of inflammation in EAP mice and EAP-alcohol mice. Patients with a history of chronic alcohol consumption were also included to evaluate the effects of chronic alcohol consumption on CP/CPPS. Subsequently, proteomic analysis, flow cytometry, immunofluorescence, Western blotting, and immunohistochemistry were utilized to investigate the underlying mechanism involved both in vivo and in vitro.ResultsHE staining, ELISA, and behavioral experiments showed that alcohol exacerbated the severity of EAP in mice and patients. Proteomic and KEGG pathway analyses showed that abnormal Th1 differentiation and PI3K/AKT/mTOR pathway were significantly enriched. Subsequent mechanistic research showed that alcohol significantly activated PI3K/AKT/mTOR pathway and increased the Th1 cell differentiation both in vivo and in vitro. In contrast, PI3K inhibitor LY294002 and shRNA-PI3K plasmid inhibited PI3K/AKT/mTOR pathway activation, reduced Th1 cell differentiation, and alleviated EAP inflammation severity, respectively.ConclusionOur study is the first to demonstrate that alcohol intake promotes Th1 cell differentiation and exacerbates EAP by activating the PI3K/AKT/mTOR pathway. Additionally, the role of LY294002 in inhibiting PI3K/AKT/mTOR pathway to relieve EAP suggests that it can serve as a promising therapeutic target for CP/CPPS.
Characteristics of ocular findings of patients with coronavirus disease 2019 in China
Authors: Wang Shudan , Feng Jiaoyang , Zhu Rui , Jin Xin , Ding Yiheng , Jin Di , Guo Yu , Zhang Hong 
Published: January 2025

PurposeThis study aimed to report the ocular manifestations in individuals with coronavirus disease 2019 (COVID-19) and investigate any correlation between the occurrence of ocular symptoms and systemic symptoms.MethodsA retrospective electronic survey was conducted among the general public in northern China from December 2022 through February 2023. Inclusion criteria for COVID-19 was confirmed testing positive via a polymerase chain reaction (PCR) test or testing positive for COVID-19 via an antigen kit. The anonymous survey collected information on demographics, systemic COVID-19 symptoms, ocular diagnosis and symptoms, comorbidities and disease history.ResultsA total of 2,405 survey responses were collected and the final analysis included individuals in the 335 COVID-19 positive group and 434 individuals in the COVID-19 negative group. Among COVID-19 positive patients 66.3% (n = 222) reported experiencing ocular symptoms. Dryness (n = 106, 31.6%), blurred vision (n = 81, 24.2%), eye pain (n = 72, 21.5%), and itching (n = 71, 21.2%) were the main features. COVID-19 was found to be associated with a higher prevalence of conjunctivitis, iritis, uveitis, retinal vein occlusion and optic neuritis. The majority of individuals (51.0%) developed eye symptoms after the onset of COVID-19 systemic symptoms. There was no significant association between the severity of systemic symptoms and ocular symptoms.ConclusionIndividuals with COVID-19 were significantly more likely to experience ocular symptoms. COVID-19 was found to be associated with a higher prevalence of retinal diseases. The majority of individuals developed ocular symptoms right after the onset of systemic symptoms.
Identifying subgroups of teacher burnout in elementary and secondary schools: the effects of teacher experience, age and gender
Authors: Alghamdi Mohammed H. , Sideridis Georgios 
Published: January 2025

IntroductionTeacher burnout is a serious problem that requires quick attention and management since it not only compromises educational quality but also strains schools’ financial resources.Research objectiveThe purpose of the present study was to profile burnout indicators for teachers in the Kingdom of Saudi Arabia. A secondary goal was to evaluate the consistency of burnout profiles between elementary and secondary school teachers.MethodParticipants were 703 teachers who participated in the Trends in International Mathematics and Science Study (TIMSS 2019) and were part of the measurement in Saudi Arabia and participated in this study. A series of nested latent class models were run using 1–6 classes to identify an optimal number of interpretable subgroups (latent classes) that best describe the latent construct of teacher burnout in the elementary and high school setting.ResultsThe most important finding was that more than one-third of the teachers reported high levels of burnout irrespective of education level or gender. Furthermore, teachers’ experience and age were positive predictors of burnout with older teachers having significantly elevated levels of burnout. Gender on the other hand did not play a significant moderating role in teachers’ levels of burnout.ImplicationsReducing the number of students in each class, reorganizing the administrative work that has to be done, adding more support personnel to classrooms, and increasing time management skills and tactics via professional development programs are all potential solutions that might help alleviate the problem of teacher burnout.
Network modeling of problematic social media use components in college student social media users
Authors: Chen Jianyong , Su Ting , Dong Junqiang , Li Yuzhi , Feng Ju , Chen Yingxiu , Liu Gu 
Published: January 2025

BackgroundWhile the constitutive features of problematic social media use (PSMU) have been formulated, there has been a lack of studies in the field examining the structure of relationships among PSMU components.MethodThis study employed network analytic methods to investigate the connectivity among PSMU components in a large sample of 1,136 college student social media users (Mage = 19.69, SD = 1.60). Components of PSMU were assessed by the Bergen Social Media Addiction Scale (BSMAS) derived from a components model of addiction. We computed two types of network models, Gaussian graphical models (GGMs) to examine network structure and influential nodes and directed acyclic graphs (DAGs) to identify the probabilistic dependencies among components.ResultRelapse component consistently emerged as a central node in the GGMs and as a parent node of other components in the DAGs. Relapse and tolerance components exhibited strong mutual connections and were linked to the most vital edges within the networks. Additionally, conflict and mood modification nodes occupied more central positions within the PSMU network for the low-BSMAS-score subgroup compared with the high-BSMAS-score subgroup.ConclusionOur findings shed new light on the complex architecture of PSMU and its potential implications for tailored interventions to relieve PSMU.
The value of privacy for people with dementia
Authors: Buhr Eike , Schweda Mark 
Published: January 2025

IntroductionThe concept of privacy marks an astonishing gap in the discussion about care for people with dementia (PwD). In general, questions of privacy play an important role and attract much attention in the ethics of nursing care. Yet, when it comes to dementia care, there is hardly any systematic ethical debate on the topic at all. It almost seems as though PwD lost any plausible interest in privacy and no longer had a private sphere that needed to be considered or protected. However, this not only contradicts widespread moral intuitions but also ignores the views and needs of those affected.ArgumentsThis conceptual analysis sets out to explore the value of privacy for PwD. We first outline the origins and dimensions of the concept of privacy itself and point out problems and limitations in the context of dementia. Especially the prevalent liberal conceptions’ dependence on the idea of individual autonomy poses considerable challenges to an adequate understanding of the moral significance of privacy for PwD. Therefore, we subsequently examine alternative ways of conceptualizing the value of privacy in the context of dementia care.ConclusionWe argue that autonomy-based concepts of privacy may still apply in the early stages of dementia. In the further course of the syndrome, however, the relevance of other normative aspects comes to the fore, especially respect for remaining personal preferences as well as objective criteria of dignity and well-being. Thus, we outline in a differentiated way how and to what extent privacy can be of normative importance even beyond the purview of autonomy and should consequently be considered in dementia care.