bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of Coronary Artery Severity and Late In-Stent Restenosis: An Angiographic Imaging Study
Authors: Oguz Mustafa , Akbulut Tayyar , Saylik Faysal , Sipal Abdulcabbar , Erdal Emrah 
Published: January 2023

Coronary in-stent restenosis (ISR) remains a challenge in interventional cardiology. We investigated the relationship between angiographic pre-interventional grade of lesion stenosis (LS) and the prognosis of late ISR. After exclusions, 110 patients with ISR and 109 patients without ISR were compared. In the ISR group, the grade of LS was greater ( P < .001) and the length of the critical segment (LCS) was longer ( P < .001). Stent length was longer in the ISR group ( P = .008). Compared with the LCS, the grade of LS above 87.5% is 6.9 times more predictive of ISR than the LCS >10.5 mm. Kaplan–Meier curve analysis showed that the grade of initial LS >87.5% had a higher ISR rate than the grade of LS <87.5% (log-rank test P < .001) and critical lesion length over 10.5 mm had a higher ISR rate than critical lesion length under 10.5 mm (log-rank test P < .001). The present study found that the angiographic pre-interventional grades of LS and LCS were important predictors of ISR. Pre-interventional angiographic stenosis >87.5% was significantly predictive of late ISR.
UK National audit of the measurement of ammonia
Authors: Aitkenhead Helen 
Published: January 2023

Background Severe hyperammonaemia is associated with significant morbidity and mortality. Rapid analysis and reporting of ammonia results is essential to prevent patient harm. The aim was to investigate the laboratory sample acceptance criteria, ammonia analysis and the reporting of ammonia results. Methods A questionnaire was distributed to clinical biochemistry laboratories in the United Kingdom. The results were collated and compared to updated best practice guidelines on hyperammonaemia issued by the Metabolic Biochemistry Network ( MetBio.net ). Results Seventy-six laboratories responded to the audit questionnaire. Although 83% laboratories are aware of the updated MetBio.net hyperammonaemia guidelines, most laboratories continue to reject samples for ammonia that are ‘too old’ for analysis (64%), haemolysed (72%) or not sent on ice (24%). Rapid ammonia analysis is available in 96% laboratories and all laboratories offer ammonia analysis on a 24/7 basis. Nearly all laboratories had implemented critical phoning limits for ammonia. Conclusions Laboratories are rejecting samples for ammonia analysis that have not been collected/transported in an optimal manner. Laboratories should review their sample acceptance criteria for ammonia and accept all samples in order to avoid delaying the diagnosis and management of hyperammonaemia.
Team Dynamics and Collaborative Problem-Solving for Lunar Construction: Lessons From Complex Construction Scenarios on Earth
Authors: Harris Katie M. , Stankovic Aleksandra , Thoolen Stijn , Strangman Gary , Caldwell Barrett , Robinson Stephen K. 
Published: January 2023

Objective This paper surveys the existing literature surrounding problem-solving and team dynamics in complex and unpredictable scenarios, and evaluates the applicability of studying Earth-based construction teams to identify training needs for Lunar construction crews. Background Lunar and other space exploration construction crews will work in extreme environments and face unpredictable challenges, necessitating real-time problem-solving to address unexpected contingencies. This work will require coordination with Mission Control and autonomous assistants, so crew training must account for multi-agent, distributed teamwork. Method A narrative literature review identified processes, attributes, and skills necessary for the success of Lunar construction teams. We summarized relevant frameworks and synthesized collective findings into over-arching trends and remaining research gaps. Results While significant literature exists surrounding team performance, very little systematic inquiry has been done with a focus on Lunar construction crews and operations, particularly with respect to dynamic problem-solving and team-based decision-making. Established and standardized metrics for evaluating team performance are lacking, resulting in significant variation in reported outcomes between studies. Conclusion Lunar and other space exploration construction teams will need training that focuses on developing the right approach to team-based problem-solving, rather than on preparing response execution for known contingencies. An investigation of successful Earth-based construction crews may facilitate the development of relevant metrics for training future Lunar construction crews. Application Metrics and team training protocols developed for future Lunar construction teams may be adaptable and applicable to a wide range of extreme teams facing uncertain challenges, such as aircrews, surgical teams, first responders, and construction crews.
Ply-Resolved Quantification of Thermal Degradation in Carbon Fibre-reinforced Polymers
Authors: Bibinger Johannes , Eibl Sebastian , Gudladt Hans-Joachim 
Published: January 2023

This study focuses on thermal degradation of carbon fibre-reinforced polymers depending on the specimen depth. For this purpose, the commercial composite HexPly® 8552/IM7 was thermally irradiated from one side with an infrared lamp at constant heat flux of 50 W/cm2 under varying exposure time. Subsequently, a defined number of plies was removed to prepare micro samples from different depths of the bulk material. Non-destructive and destructive testing methods were used to characterize the thermal degradation mechanism and mechanical properties of these specimens. The results showed that during thermal loading temperature and consequently damage gradients manifest along the material cross-section. Thereby, the damage distribution could be divided into the regions rI with matrix depletion, rII with and rIII without structural damage such as delaminations, cracks and pores. By means of ply-resolved investigations, the influence of these regions and corresponding decomposition processes on the mechanical properties could be determined. As a result, a simple damage model was introduced to calculate the residual strength from the initial strength, region sizes and sensitivity factors representing the effect of thermo-induced damage on strength types.
Effect of Kaolin powder on the static and dynamic behavior of heterogeneous laminate constituted of functionally graded material layers
Authors: Roubache Ridha , May Abdelghani , Boudiaf Mohamed Daia Dine , Benhammouda Seif Eddine , Aït Hocine Nourredine 
Published: January 2023

This work investigated the mechanical properties of glass/epoxy laminates reinforced by kaolin powder with graded properties by performing tensile, 3-point bending, impact tests, and compression after impact (CAI) tests. Firstly, we evaluated the effects of mixing parameters on particle dispersion and the effect of kaolin powder rate on the epoxy properties. It was found that the optimal parameters for a good distribution are a temperature of 60°C with 10 min of stirring time and the optimum kaolin powder rate is 5 wt %. Secondly, four graded heterogeneous laminates were elaborated with increased powder rate at each 1, 2, 3, and 4 layers named models 1/1, 2/2, 3/3, and 4/4, respectively. The test results showed that the powder gradient distribution considerably influences the behavior of the composite, with a significant improvement in mechanical properties compared to unreinforced glass/epoxy laminates. The model 1/1 on the top side exhibits the most significant increase in flexural modulus and maximum flexural strength, respectively, compared to the unfilled specimen. The impact tests showed that the powder distribution gradient is essential in absorbing the leading force and energy. The model 1/1 on the top side showed the best impact strength. According to this previous finding, adding ceramic particles in a polymer matrix; with a particular gradient distribution; significantly enhances the composite laminates' properties, especially under bending load. This heterogeneous composite type finds its application in closed structures where the load side is known, such as tanks and aircraft wings, and will allow a considerable weight gain.
Decreased walking efficiency in elementary school children with developmental coordination disorder trait
Authors: Ito Tadashi , Sugiura Hideshi , Ito Yuji , Nakai Akio , Narahara Sho , Noritake Koji , Takahashi Daiki , Natsume Jun , Ochi Nobuhiko 
Published: January 2023

Objective To compare walking efficiency, and associated physical function, between children, with and without developmental coordination disorder trait. Design Cross-sectional study. Setting The study was conducted in a Medical and Rehabilitation Center for Developmental Disabilities in Okazaki, Japan. Subjects The study included 286 children, 6–12 years of age, with and without developmental coordination disorder trait. Developmental coordination disorder trait was defined by a score below the −1 standard deviation on the Japanese version of the Developmental Coordination Disorder Questionnaire. Based on this criterion, 45 children (28 boys) were classified into the developmental coordination disorder trait group and the other 241 (115 boys) in the control group. Measures The following physical function outcomes were measured: single leg stance test; step length variability; and walking efficiency, measured using the 2-min walk test. Logistic regression analysis was used to determine the association between developmental coordination disorder trait and lower walking efficiency and physical function. Results Compared to the control group, the developmental coordination disorder group showed lower walking efficiency ( P  =  0.026), higher step length variability ( P  =  0.047), and shorter single leg stance test ( P  =  0.001). Developmental coordination disorder was independently associated with walking efficiency (odds ratio, 1.03; 95% confidence interval [CI], 1.001–1.061; P  =  0.041) and single leg stance test (odds ratio, 0.99; 95% CI, 0.978–0.996; P  =  0.006), but not to step length variability, age, and sex. Conclusions Lower walking efficiency increases energy expenditure in children with developmental coordination disorder trait. Interventions to improve walking efficiency could improve the physical function and participation of these children.
Primary headache disorders in Latin America and the Caribbean: A meta-analysis of population-based studies
Authors: Pacheco-Barrios Kevin , Velasquez-Rimachi Victor , Navarro-Flores Alba , Huerta-Rosario Andrely , Morán-Mariños Cristian , Molina Roberto A , Farroñay-García Chandel , Metcalf Tatiana , Fregni Felipe , Alva-Díaz Carlos 
Published: January 2023

Background In this manuscript, we aim to systematically estimate the pooled prevalence and incidence of primary headaches and its subtypes (migraine, tension-type headache, and chronic headaches) in Latin America and the Caribbean, describing its epidemiological profile and associated factors. Methods We systematically searched PubMed/MEDLINE, Scopus, and LILACS (From conception to March 2021), for populational studies reporting the epidemiology of primary headaches and their associated factors in Latin America and the Caribbean. The data extraction was conducted independently. We performed random-effect model meta-analysis of prevalence (overall primary headaches and by subtypes) and associated factors, assessed potential sources of heterogeneity, the risk of bias, publication bias, and the evidence certainty (GRADE methodology). Results We included 32 populational studies (38 subpopulations, n = 63,813). The prevalence of primary headaches was 41.4% (95% CI 31.1–52.2%; n = 54,357), 15% for migraine (95% CI 12.0–18.3; n = 53,658 individuals), 20.6% for tension-type headache (95% CI 12.4–30.2; n = 25,840), and 6% for chronic headaches (95% CI 3.3–9.6; n = 21,720), with high between-study heterogeneity. No incidence data was found. Female sex, white ethnicity, high BMI, comorbid mental health disorders, and low-back pain were associated with higher prevalence of primary headaches. The prevalence was less in rural areas. Conclusion In Latin America and the Caribbean, primary headaches are highly prevalent affecting young females disproportionally. The prevalence of chronic headaches is higher than in other systematic global and regional estimations. The presence of comorbidities as modifiable risk factors should encourage their integration as targets for community-based preventive and therapeutic interventions. Protocol registration number CRD42018105116
Headache attributed to SARS-CoV-2 infection, vaccination and the impact on primary headache disorders of the COVID-19 pandemic: A comprehensive review
Authors: Caronna Edoardo , van den Hoek Thomas C , Bolay Hayrunnisa , Garcia-Azorin David , Gago-Veiga Ana Beatriz , Valeriani Massimiliano , Takizawa Tsubasa , Messlinger Karl , Shapiro Robert E , Goadsby Peter J , Ashina Messoud , Tassorelli Cristina , Diener Hans-Christoph , Terwindt Gisela M , Pozo-Rosich Patricia 
Published: January 2023

Objective The objective is to summarize the knowledge on the epidemiology, pathophysiology and management of secondary headache attributed to SARS-CoV-2 infection and vaccination; as well as to delineate their impact on primary headache disorders. Methods This is a narrative review of the literature regarding primary and secondary headache disorders in the setting of COVID-19 pandemic. We conducted a literature search in 2022 on PubMed, with the keywords “COVID 19” or “vaccine” and “headache” to assess the appropriateness of all published articles for their inclusion in the review. Results Headache is a common and sometimes difficult-to-treat symptom of both the acute and post-acute phase of SARS-CoV-2 infection. Different pathophysiological mechanisms may be involved, with the trigeminovascular system as a plausible target. Specific evidence-based effective therapeutic options are lacking at present. Headache attributed to SARS-CoV-2 vaccinations is also common, its pathophysiology being unclear. People with primary headache disorders experience headache in the acute phase of COVID-19 and after vaccination more commonly than the general population. Pandemic measures, forcing lifestyle changes, seemed to have had a positive impact on migraine, and changes in headache care (telemedicine) have been effectively introduced. Conclusions The ongoing COVID-19 pandemic is a global challenge, having an impact on the development of secondary headaches, both in people with or without primary headaches. This has created opportunities to better understand and treat headache and to potentiate strategies to manage patients and ensure care.
Modification and evaluation of diatrizoate sodium containing polymethyl methacrylate bone cement
Authors: Han Jintong , Zheng Xiaoqiang , Liu Jingyu , Wang Yifan , Cui Zhenduo , Wu Shuilin , Liang Yanqin , Zhu Shengli , Ge Xiang , Li Zhaoyang 
Published: January 2023

Polymethyl methacrylate (PMMA) bone cement is now widely used in percutaneous vertebro plasty (PVP) and percutaneous kyphoplasty (PKP). However, studies showed that the radiopacifiers (zirconia, barium sulfate, etc.) added to PMMA will have a negative impact on its use, e.g. barium sulfate will weaken the mechanical properties of bone cement and lead to bone absorption and aseptic loosening. Iodine is an element existing in the human body and has good imaging performance. Iodine contrast agent has been used in clinic for many years and has abundant clinical data. Therefore, using iodine instead of barium sulfate may be a promising choice. In this paper, the effect of different content of diatrizoate sodium (DTA, C11H8I3N2NaO4) on the properties of PMMA was studied and compared with the traditional PMMA bone cement containing 30 wt% barium sulfate. The mechanical properties, setting properties, radiopacity, and biocompatibility of bone cement were evaluated. The compressive strength of PMMA bone cement with 20 wt% DTA can reach 76.38 MPa. DTA released from bone cement up to 14 days accounted for only 2.3% of its dosage. The water contact angle was 62.3°. The contrast of bone cement on X-ray film was comparable to that of bone cement containing 30 wt% barium. The hemolysis rate was lower than 4%, and there was no obvious hemolysis. PMMA with 20 wt% DTA can maintain the relative growth rate of MC3T3-E1 and L929 cells above 80%. The results show that adding 20 wt% DTA into PMMA can obtain good radiopacity while maintaining its mechanical properties, setting properties, and biocompatibility. DTA can be used as a promising candidate material for PMMA bone cement radiopacifier.
Medication Profiles at Hospital Discharge Predict Poor Outcomes After Acute Ischemic Stroke
Authors: Barra Megan E. , Giulietti Jennifer M. , DiCarlo Julie A. , Erler Kimberly S. , Krenz James , Roberts Russel J. , Lin David J. 
Published: January 2023

Objectives: To examine the relationship between medications prescribed during the first 6-months post-stroke and functional outcome. Materials and Methods: A retrospective analysis of ischemic stroke survivors enrolled in an observational stroke recovery study from June-2017 to July-2019 was performed. Survivors with favorable outcomes (modified rankin scale (mRS) score 0-2) were compared to those with unfavorable outcomes (mRS ≥3) 6-months after stroke on the following: discharge medication classes prescribed, achievement of recommended targets for blood pressure control, glycemic control, and LDL ≤70 mg/dL, medication changes, medication interactions, and medication list discrepancies. Results: Unfavorable 6-month outcomes occurred in 36/78 (46.2%) of survivors. Survivors with unfavorable outcomes were more likely to be prescribed a central nervous system-acting agent (97.2% vs 71.4%; P = .0022) and/or an anti-hyperglycemic agent (25.0% vs 9.5%; P = .009) at discharge. After adjustment of baseline covariates, total number of medications prescribed was associated with unfavorable 6-month outcomes (OR 1.13, 95% CI 1.0-1.28). Secondary stroke prevention measures were not achieved in a high proportion of survivors. Medication changes during 6-month follow up were common and survivors with unfavorable outcomes were more likely to have clinically significant drug-drug interactions. Discussion: At 6-months, survivors with unfavorable outcomes were found to be prescribed more medications, particularly central nervous system-acting and anti-hyperglycemic agents. There were also more drug-drug interactions in the medications prescribed compared to those with favorable outcomes. Together, these data suggest the need for enhanced screening of high-risk stroke survivors focused on close monitoring of polypharmacy, drug-drug interactions, and adverse events with pharmacotherapy.
Kaempferol ameliorates palmitate-induced lipid accumulation in HepG2 cells through activation of the Nrf2 signaling pathway
Authors: Zhao Li , Yang Liping , Ahmad Khalidamir 
Published: January 2023

Objectives Kaempferol (KMF), has beneficial effects against hepatic lipid accumulation. In this study, we aimed to investigate molecular mechanism underlying the protective effect of KMF on lipid accumulation. Methods HepG2 cells were treated with different concentrations of KMF and 0.5 mM palmitate (PA) for 24  h. The mRNA and protein levels of genes involved in lipid metabolism were evaluated using real-time PCR and western blot. The expression of Nrf2 was silenced using siRNA. Results Data indicated that KMF (20 μM) reversed PA-induced increased triglyceride (TG) levels and total lipid content. These effects were accompanied by down-regulation of the mRNA and protein levels of lipogenic genes (FAS, ACC and SREBP1), and up-regulation of genes related to fatty acid oxidation (CPT-1, HADHα and PPARα). Kaempferol significantly decreased the levels of the oxidative stress markers (ROS and MDA) and enhanced the activities of antioxidant enzymes SOD and GPx in PA-challenged cells. Luciferase analysis showed that KMF increased the transactivation of Nrf2 in hepatocytes. The results also revealed that KMF-mediated activation of Nrf2 target genes was suppressed by Nrf2 siRNA. Furthermore, Nrf2 siRNA abolished the KMF-induced reduction in ROS and MDA levels in PA treated cells. In addition, the inhibitory effect of KMF on TG levels and the mRNA and protein levels of FAS, ACC and SREPB-1 were significantly abolished by Nrf2 inhibition. Nrf2 inhibition also suppressed the KMF-induced activation of genes involved in β oxidation (CPT-1 and PPAR-α). Conclusion The results suggest that KMF protects HepG2 cells from PA-induced lipid accumulation via activation of the Nrf2 signaling pathway.
Cardiac Mitochondrial Calcium Loading Capacity is Severely Affected after Chronic Cholestasis in Wistar Rats
Authors: Oliveira Paulo J. , Rolo Anabela P. , Seiça Raquel , Santos Maria S. , Palmeira Carlos M. , Moreno António J. M. 
Published: January 2023

Background Cardiovascular changes correlated with some forms of hepatic disease are being reported in the literature. Objectives: The aim of this work was to characterize cardiac mitochondrial bioenergetics and calcium buffering capacity in Wistar rats injected with six weekly doses of α-naphthylisothio-cyanate (ANIT), a compound known to induce cholestasis in animal models. Methods Isolated heart mitochondria were obtained from both injected and control animals and bioenergetic parameters were measured, as well as the capacity to buffer externally added calcium and the mitochondrial content of reduced protein thiol groups. Blood biochemistry analyses were obtained at the initial and end points of treatment. The in vitro ANIT effect on isolated heart mitochondria was also studied. Results and Discussion Our results showed that the respiratory control ratio was the only parameter affected in injected animals ( p < .05, n = 5). Nevertheless, heart mitochondria from injected animals showed an inability to accumulate added calcium owing to an increased susceptibility to the calcium-dependent mitochondrial permeability transition ( p < .0001, n = 5). The effects were still present 1 week after ending ANIT administration, when serum markers for liver injury and hyperbilirubinemia were already abated (although in the presence of bile duct proliferation). To our knowledge, this is the first time that cardiac mitochondrial calcium homeostasis and mitochondrial respiratory ratio are seen affected during ANIT-induced cholestasis, prevailing even in the absence of hepatic damage serum markers.