bluuebunny/crossref_metadata_2025_split huggingface dataset:
Principes, cadre d'analyse et leviers d'action à l’échelle de l’élevage pour une gestion intégrée de la santé chez les animaux monogastriques
Authors: FORTUN-LAMOTHE Laurence , COLLIN Anne , COMBES Sylvie , FERCHAUD Stéphane , GERMAIN Karine , GUILLOTEAU Laurence , GUNIA Mélanie , LEFLOC’H Nathalie , MANOLI Claire , MONTAGNE Lucile , SAVIETTO Davi 
Published: January 2023

La gestion intégrée de la santé animale peut être définie comme l’ensemble des connaissances et pratiques mobilisées par l’homme de manière coordonnée afin de favoriser la construction, préserver ou retrouver la santé des individus ou du troupeau au sein du système d'élevage. Elle a pour finalité d’optimiser la santé animale et le cycle de production tout en réduisant l’utilisation des antibiotiques et des antiparasitaires qui pose des problèmes de résistance chez les animaux et les humains. Elle se fonde sur la mobilisation conjointe de trois principes complémentaires : (P1) prévenir l’apparition des maladies en limitant les situations à risques et le contact avec les éléments nuisibles (agents pathogènes, éléments toxiques), (P2) utiliser des animaux résistants ou développer leurs capacités adaptatives, (P3) soigner les animaux de façon ciblée (molécule, dose, durée). La santé se construit tout au long de la vie de l’animal pour garantir un développement harmonieux et l’intégrité physique des individus. De nombreux leviers d’action, regroupés en six dimensions (1-milieu de vie des animaux, 2-gestion de la reproduction, 3-gestion des troupeaux, 4-choix et pratiques avec les animaux, 5-alimentation et 6-pilotage de l’élevage) ont été identifiés pour atteindre cet objectif. Ces leviers peuvent avoir sur la santé un effet direct, différé, ou bien intergénérationnel. Une mobilisation cohérente de nombreux leviers a permis de réduire fortement l’usage des antibiotiques au cours des dernières années mais une marge de progrès est encore possible pour les systèmes d’élevages des monogastriques. De plus, le développement de systèmes d’élevage en phase avec les demandes sociétales (respect du bien-être animal, circuits courts et locaux, accès à l’extérieur) pose de nouveaux défis pour une gestion intégrée de la santé animale.
Perceived playfulness, perceived usefulness, confirmation dan continuance intention pada layanan video on demand: satisfaction sebagai mediasi
Authors: Andrew Roberto , Ardianti Retno 
Published: January 2023

Di tengah meningkatnya jumlah pelanggan video on demand (VOD) selama pandemi, penelitian selama ini belum menjelaskan tentang hal-hal yang membentuk intensi pelanggan untuk melanjutkan berlangganan layanan tersebut. Oleh karena itu, penelitian ini bertujuan untuk menjelaskan pengaruh perceived playfulness, perceived usefulness, dan confirmation terhadap continuance intention dengan satisfaction sebagai variabel yang memediasi. Dengan menggunakan partial least square (PLS) sebagai teknik analisa data, hasil penelitian menunjukkan pentingnya kesesuaian antara ekspektasi dengan pengalaman riil pelanggan dalam menggunakan layanan VOD terhadap continuance intention. Selain itu hasil riset juga menunjukan kontribusi satisfaction sebagai full ataupun partial mediating variable dalam menjelaskan pengaruh perceived playfulness, perceived usefulness dan confirmation terhadap continuance intention.
Phytochemical constituents, antioxidant and antibacterial activities of Plectocephalus varians (A. Rich) C. Jeffrey ex Cufod root extracts
Authors: Gashaye Melaku Birhane , Birhan Yihenew Simegniew 
Published: January 2023

Abstract
Plants have been used to treat diverse types of diseases in different cultural groups around the globe. In this regard, the root of Plectocephalus varians (P. varians) is claimed to have a beneficiary effect in treating cancer and hemorrhoids in Ethiopia. Hence, this study aimed at the phytochemical investigation, antioxidant, and antibacterial activities of n-hexane, acetone, and methanolic extracts of P. varians root. The different crude extracts of P. varians were obtained through maceration technique. The total phenolic content (TPC) and total flavonoid contents (TFC) of the extracts were estimated using Folin-Ciocalteu Reagent (FCR) and aluminum chloride colorimetric assays, respectively. The antioxidant activities of the extracts were determined by 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging and ferric reducing antioxidant power (FRAP) assays. The antibacterial activities of the extracts were assessed by using disc diffusion method. The results echoed the presence of alkaloids, saponins, flavonoids, steroids, phenols, tannins, anthraquinones, terpenoids, polyphenols, and glycosides in the root of P. varians. The methanolic root extract (MRE) had the highest TPC (107.18 mgGAE/g) and TFC (120.194 mgQE/g) followed by acetone root extract (ARE) (TPC = 98.68 mgGAE/g; TFC = 64.038 mgQE/g) and n-hexane root extract (HRE) (TPC = 12.39 mgGAE/g; TFC = 9.917 mgQE/g). The DPPH radical scavenging and FRAP assays demonstrated the antioxidant effects of HRE (IC50 = 681.75 ppm; EC50 = 60.65 ppm), ARE (IC50 = 165.73 ppm; EC50 = 51.67 ppm) and MRE (IC50 = 132.06 ppm; EC50 = 30.97 ppm) of P. varians. Furthermore, the root fractions elicited pronounced dose-dependent growth inhibition against Staphylococcus aureus, Streptococci pyogenes, Escherichia coli, and Klebsiella pneumoniae with mean zone of inhibition (MZI) ranging from 11 ± 0.38 to 20 ± 0.04 mm at 800 ppm. Overall, the present study provides ethnopharmacological evidence suggesting the medicinal importance of P. varians. The results also call for further bioassay-guided phytochemical screening and in vitro and/or in vivo bioactivity testing.
Tenofovir disoproxil fumarate is superior to Entecavir and Tenofovir alafenamide in Cost-Effectiveness of Treatment of Chronic Hepatitis B in China with New Volume-Based Purchasing Policy
Authors: Lin Yi , Lin Xueyan , Chen Juan , Lin Zhihui 
Published: January 2023

Abstract
Background/Aim:
Evidence indicates long-term nucleos(t)ide analogs (NAs) therapy can improve the prognosis of chronic hepatitis B (CHB). However, the optimized choice of first-line NAs in cost-effectiveness was still obscure. In 2019, China’s New Volume-Based Purchasing Policy (NVBPP) was implemented with a significant price reduction of entecavir (ETV), tenofovir disoproxil fumarate (TDF). This study evaluated the cost-effectiveness of ETV, TDF, and Tenofovir alafenamide (TAF) with or without NVBPP treatment of CHB in China from a social perspective.
Methods
A state-transition model was founded based on the paraments from published literature to compare treatment strategies involving non-NAs best support care (BSC), ETV, TDF with or without NVBPP, and TAF. A lifetime time cohort was simulated. Outcomes measured were predicted the number of liver-related deaths, costs, quality-adjusted-life-years (QALYs), and incremental cost-effectiveness ratios (ICERs).
Results
Compare to non-NAs BSC, the TAF generated an additional 2.38 QALYs/person at an additional cost of 17899.62USD with an ICER of 7520.85USD/QALY. Following, the TDF generated an additional 2.32 QALYs/person with an ICER of 6,301.84USD/QALY and ETV generated an additional 1.77 QALYs with an ICER of 11,397.28USD/QALY. With NVBPP, the ICER of TDF decreased to -66.38USD/QALY, and ETV decreased to -611.44USD/QALY compared to non-NAs BSC. With willingness-to-pay (WTP) thresholds of 30000USD/QALY, TDF with NVBPP had a 78.29% probability of being the optimal treatment strategy followed by ETV with NVBPP at 14.23% and TAF at 7.48% in the iterations.
Conclusion
In our analyses, the TDF with NVBPP would be the most cost-effect long-term therapy for CHB, followed by ETV with NVBPP and TAF. The ETV and TDF without NVBPP were cost-effectiveness-dominated.
Coping with Bowel and Bladder Dysfunction After SCI: A Comparison between India and Canada
Authors: Krassioukov Andrei , hirsch Aliza , Tyagi Nishu , Goel Shakti , Chhabra H S , Fallah Nader , Noonan Vanessa , Sehrawat Shikha , Saini Aditya , Barnwal Aniket 
Published: January 2023

Abstract
Study Design: A cross-sectional design.
Objectives:This is an exploratory study to better understand how individuals with SCI in these diverse countries are managing and coping with bladder and bowel dysfunction.
Setting: Our project is a collaboration between two centers: the International Collaboration on Repair Discoveries (ICORD)/Blusson Spinal Cord Center in Vancouver, Canada and the Indian Spinal Injuries Centre in New Delhi, India.
Methods: Data from thirty-three participants was analyzed. Participants completed an online questionnaire that included demographic information and assessed bowel and bladder functioning using the Neurogenic Bowel Dysfunction (NBD) score, Wexner Incontinence score (WIS), Neurogenic Bladder Symptom Score (NBSS) and the Incontinence QOL (I-QOL). Continuous data were compared using t-tests; for not normally distributed data Mann-Whitney U tests used. For evaluation of association between categorical variables, Fisher’s exact test or Chi-square was used.
Results: The Canadian sample reported higher NBD total scores indicating more severe bowel dysfunction, less daily bowel movements, and was more likely to experience uneasiness, headaches, and perspiration during bowel movements. The NBSS indicated a higher proportion of the Indian sample was unsatisfied or unhappy with their bladder function. The distribution of the WIS and I-QOL scores were the same across both countries.
Conclusion: Potential explanations for differences include diet, methods of management, financial resources, as well as patient and caregiver education. These variables are heavily influenced by cultural, geographical, and economic circumstances.
Accurate aging clocks based on accumulating stochastic variation
Authors: Schumacher Björn , Meyer David 
Published: January 2023

Abstract

Aging clocks have provided one of the most significant recent breakthroughs in the biology of aging. Such clocks allow the determination of chronological and increasingly also biological age, which is prerequisite for assessing the effectiveness of interventions in the aging process and preventive treatments of age-related diseases. The most advanced aging clocks are based on age-dependent changes in DNA methylation pattern. The reproducibility of such changes over the life course has reinvigorated the debate whether a programmed process underlies aging. A programmed aging process, however, is incompatibly with the evolutionary theory of aging. Aging occurs as a consequence of a vanishing force of selective pressure post-reproduction as no fitness benefit is provided by immortality of the soma. In fact, stochastic events have been observed to increasingly occur during the aging process. Here, we test whether aging clocks could be built with entirely stochastic variation. We find that accumulating stochastic variation is sufficient to accurately predict chronological and biological age. Moreover, current aging clocks are entirely compatible with random alterations in the methylation or transcriptomic patterns. Our analysis unifies the clock measure of aging with the evolutionary theory of aging and predicts that any set of data that have a ground state at the age zero with accumulating stochastic variation could be used for building accurate aging clocks.
Phase II study of IRInotecan treatment after COmbined chemo-immunotherapy for extensive-stage small-cell lung cancer: protocol of IRICO study
Authors: Tomono Hiromi , Taniguchi Hirokazu , Fukuda Minoru , Ikeda Takaya , Nagashima Seiji , Akagi Kazumasa , Ono Sawana , Umeyama Yasuhiro , Shimada Midori , Gyotoku Hiroshi , Takemoto Shinnosuke , Yamaguchi Hiroyuki , Hisamatsu Yasushi , Morinaga Ryotaro , Tagawa Ryuta , Ogata Ryosuke , Dotsu Yosuke , Senju Hiroaki , Soda Hiroshi , Nakatomi Katsumi , Hayashi Fumiko , Sugasaki Nanae , Kinoshita Akitoshi , Mukae Hiroshi 
Published: January 2023

Abstract
Introduction
Combined treatment using anti-programmed death-ligand 1 antibody (anti-PD-L1) and platinum-etoposide is the current standard first-line treatment for patients with extensive-stage (ES) small cell lung cancer (SCLC). However, the best treatment for relapsed ES-SCLC after the first-line treatment remains unclear. There are some approved chemotherapeutic agents that can be used against ES-SCLC, and treatment with irinotecan is well established as both, a monotherapy and a combined therapy, in combination with platinum. Therefore, we conduct a phase II study with irinotecan in the second- or later-line setting for patients with ES-SCLC who are previously treated with a combination of anti-PD-L1 and platinum-etoposide.
Methods
Our study will enroll patients who are diagnosed with ES-SCLC and experienced disease progression after treatment of anti-PD-L1 and platinum-etoposide. Patients will receive irinotecan on days 1, 8, and 15, which will be repeated every 4 weeks. Doses of irinotecan (100/80/60 mg/m2) will be determined according to the type of UGT1A1 gene polymorphism, and the treatment will be discontinued following disease progression, intolerance, withdrawal of patient consent, and based on the investigator’s decision. The primary endpoint of the study is the response rate, and the secondary endpoints are overall survival, progression-free survival, and safety.
Discussion
Since the present first-line treatment has been changed to combined treatment with anti-PD-L1 and platinum-etoposide, the second- or later-line treatment should be re-evaluated for patients with relapsed SCLC. Irinotecan is a major chemotherapeutic agent used for SCLC. This IRICO study demonstrates and re-evaluates the clinical benefits of irinotecan after combined treatment with anti-PD-L1 and platinum-etoposide for patients with ES-SCLC.
Registration details
This study was registered in the Japan Registry of Clinical Trials (no. jRCT s071210090) on November 4, 2021.
Optimization and Characterization of Arrowroot Porous Starch Using Thermostable α-amylase by Response Surface Methodology
Authors: Subando Teresa Ramadhinara , Pranoto Yudi , Witasari Lucia Dhiantika 
Published: January 2023

Abstract
Arrowroot is a local tuber from Indonesia with a high starch content and potential source as a porous starch (PS) material. However, the utilization of arrowroot starch as PS and optimization of PS production using the Central Composite Design (CCD) has not been explored. This study aims to optimize the incubation time (3, 6, and 9 h) and enzyme concentration (50, 100, and 150 U/g) of arrowroot PS production with thermostable α-amylase (AA) by response surface method using the CCD model. The starch suspension (25% w/v) was hydrolyzed with AA at sub-gelatinization temperature (60°C) and the effects of incubation time (3, 6, 8, 10, and 12 h) and enzyme concentration (50, 100, 150, 200, and 300 U/g) on functional characteristics of PS (Water (WAC) and Oil Absorption Capacity (OAC)) were determined to obtain near optimal value for further optimization in CCD. The result concludes and validate that the optimum condition of 5.24 h incubation time and 107.86 U/g AA concentration may achieve maximum WAC and OAC of 96.67% and 103,06%. The optimal PS also showed an improved AR (25.01%), high solubility (88.92%), and lower amylose content (36.56%) against non-modified starch. SEM result confirms porous structure. FTIR data shows increase in intensities and no alterations in functional groups. XRD data reports changes of crystalline type of CA to A, and a decrease in relative crystalline value. These data demonstrate that arrowroot can be used as an alternative economical local source in porous starch production for adsorbent application in various fields.
Potential factors affecting the impact of Community Reinforcement and Family Training. Secondary Analysis of an RCT
Authors: Hellum Rikke , Bilberg Randi , Majldal Anna , Nielsen Anette 
Published: January 2023

Abstract
Background

In addition to increasing the quality of life among concerned significant others (CSOs), Community Reinforcement and Family training (CRAFT) aim at helping CSOs motivate treatment-refusing identified patients (IPs) into treatment through a positive reinforcement process. The aim of the present study was to investigate if the following factors have an influence on IP treatment engagement1) Type of relation between CSO and the IP 2) The amount of time the CSO spend with the IP 3) if the IP knows that the CSOs seeks help, and 4) The CSO’s own alcohol use.

Methods

A secondary analysis from the Danish CRAFT study. CSOs completed a self-administered questionnaire at baseline, after three months, and six months. To investigate the relationship between the four variables and treatment engagement, logistic regression was used.

Results

CSO’s relation to the IP, the frequency of contact between the CSO and the IP, and the CSO’s AUDIT score were not associated with the IP’s treatment engagement. If the IP was informed that the CSO participated in CRAFT, the odds for IP treatment engagement was significantly higher (adjusted OR [(CI)] = 2.29 [1.13; 4.63] (p < 0.05), relative to the if IP not being informed.

Conclusions

CRAFT has a higher impact on the likelihood for treatment seeking, if the CSOs inform the IP about his or her own help seeking in order to change the situation. The underlying mechanism behind this is needs further investigations.
Evaluating the implementation of EPAs in undergraduate medical education with the RIME model
Authors: Buyck Michael , Nendaz Mathieu , Savoldelli Georges , Audétat Marie-Claude 
Published: January 2023

Abstract
Background: Undergraduate Entrustable Professional Activities (EPAs) are intended to entrust future physicians with a number of clinical tasks from their first day of residency, in accordance with the competency-based medical education (CBME) reform. While the development and implementation of EPAs has been widely published in postgraduate, little is known about the actual use of undergraduate EPAs and whether their evaluation follows a progression in terms of complexity and autonomy over the course of the clerkship.
Methods: This is a descriptive study of undergraduate EPAs reported during the first clerkship year of the University of Geneva medical school. The EPAs are grouped according to the related RIME roles (Reporter, Interpreter, Manager and Educator) to assess the number of occurrences and conditions of supervision of clinical tasks.
Results: Two cohorts recorded 42642 EPAs over the two years after the CBME implementation. 55.2% of the EPAs were related to the Reporter role, 22.1% to the Interpreter role, 19.1% to the Manager role, and 3.6% to the Educator role. The EPAs are mainly evaluated as observer or under direct supervision. Neither the number of EPAs related to higher RIME roles, nor the percentage of indirect supervision increased over the 12 months of clerkship.
Conclusions: During their first year of clerkship at the University of Geneva school of medicine, students do not seem to increase their exposure to EPAs related to higher RIME roles, nor to gain in autonomy regarding the clinical tasks they carry out. This might be due to insufficient entrustment conditions, highlighting the importance of reflection on clerkship conditions to align with CBME.
The effect of formal education on food security in Togo: evidence from the food insecurity experience scale
Authors: GNEDEKA Kodjo Théodore , WONYRA Kwami Ossadzifo 
Published: January 2023

Abstract
The objective of this paper is to analyze the effect of formal education level on food security status at the individual level in Togo. The Food and Agriculture Organization of the United Nations' Food Insecurity Experience Scale (FIES) measure is the basis of the analysis. Using the Chi-square test and probit model, we found that there is a significant difference between the individual's education level and food security status. In addition, the probability that the individual is food secure increases with his or her education level. Finally, the study shows the existence of significant heterogeneity in the determinants of food security according to the gender of the individual. To this end, any policy aimed at investing in the education of the Togolese population while favoring vulnerable groups is desirable.
JEL code: Q18; I2
Common factors among three types of cells aged in mice
Authors: Radak Mehran , Ghamari Nakisa , Fallahi Hossein 
Published: January 2023

Abstract
The greatest risk factor for the formation of numerous significant chronic disorders is aging. Understanding the core molecular underpinnings of aging can help to slow down the inevitable process. Systematic study of gene expression or DNA methylation data is possible at the transcriptomics and epigenetics levels. DNA methylation and gene expression are both affected by aging. Gene expression is an important element in the aging of Homo sapiens. In this work, we evaluated the expression of differentially expressed genes (DEGs), proteins, and transcription factors (TFs) in three different types of cells in mice: antibody-secreting cells, cardiac mesenchymal stromal cells, and skeletal muscle cells. The goal of this article is to uncover a common cause during aging among these cells in order to increase understanding about establishing complete techniques for preventing aging and improving people's quality of life. We conducted a comprehensive network-based investigation to establish which genes and proteins are shared by the three different types of aged cells. Our findings clearly indicated that aging induces gene dysregulation in immune, pharmacological, and apoptotic pathways. Furthermore, our research developed a list of hub genes with differential expression in aging responses that should be investigated further to discover viable anti-aging treatments.
Retrospective Analysis of Clinical Characteristics and Treatment of Children and Adolescents with Depression
Authors: Jiang Xiaolu , Zheng Hongyu , Yang Rong , Wang Shuo , zhong Hui 
Published: January 2023

Abstract
The purpose of this study was to analyze the demographics, clinical characteristics, and treatment of depression in children and adolescents in different age groups. A total of 635 cases of children and adolescents with depression in a hospital were collected through electronic records from January 2014 to December 2021. They were grouped according to the age of onset, amounting to 115 cases in childhood (8–12), 359 early adolescents (13–15), and 161 cases in late adolescence (16–18). The three groups were compared in terms of general conditions, clinical characteristics, and treatment. Results showed that over the past 8 years, the proportion of hospitalizations in the early adolescence group has been increasing, that in the late adolescence group was lower than that in previous years, and gender (X2 = 16.66, P < 0.001), psychotic symptoms (X2 = 6.224, P = 0.045), and disease course (Z = 84.617, P < 0.001) were significantly different. No significant differences were found in drug treatment regimen, suicide, length of hospital stay, or family history among the three groups. There were differences in the general conditions and clinical characteristics of children and adolescents with depression at different onset ages. The number of hospitalized children and adolescents with depression is increasing annually, and the proportion of hospitalizations in the children group was higher than that in previous years. Females are more likely to suffer from the disease and present more psychotic symptoms. The course of the disease in the early adolescence group was shorter than that in the other two groups, and the late adolescence group had more males and fewer psychotic symptoms.