bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lung Cancer among Industrial Sand Workers Exposed to Crystalline Silica
Authors: Steenland Kyle , Sanderson Wayne 
Published: July 2002

Abstract
In 1997, the International Agency for Research on Cancer determined that crystalline silica was a human carcinogen but noted inconsistencies in the epidemiology. There are few exposure-response analyses. The authors examined lung cancer mortality among 4,626 industrial sand workers, estimating exposure via a job-exposure matrix based on 4,269 industrial hygiene samples collected in 1974–1995. The average length of employment was 9 years, and estimated average exposure was 0.05 mg/m3 (the National Institute of Occupational Safety and Health Recommended Exposure Limit). Results confirmed excess mortality from silicosis/pneumoconioses (standardized mortality ratio = 18.2, 95% confidence interval: 10.6, 29.1; 17 deaths). The lung cancer standardized mortality ratio was 1.60 (95% confidence interval: 1.31, 1.93; 109 deaths). Limited data suggested that smoking might account for 10–20% of the lung cancer excess. Exposure-response analyses by quartile of cumulative exposure (15-year lag) yielded standardized rate ratios of 1.00, 0.78, 1.51, and 1.57 (p for trend = 0.07). Nested case-control analyses after exclusion of short-term workers, who had high overall morality, yielded odds ratios by quartile of cumulative exposure (15-year lag) of 1.00, 1.35, 1.63, and 2.00 (p for trend = 0.08) and odds ratios by quartile of average exposure of 1.00, 0.92, 1.44, and 2.26 (p = 0.005). These data lend support to the labeling by the International Agency for Research on Cancer of silica as a human carcinogen. There are approximately 2 million US workers exposed to silica; 100,000 are exposed to more than 0.1 mg/m3.
Removing near-neighbour redundancy from large protein sequence collections.
Authors: Holm L , Sander C 
Published: July 2002

Abstract
MOTIVATION: To maximize the chances of biological discovery, homology searching must use an up-to-date collection of sequences. However, the available sequence databases are growing rapidly and are partially redundant in content. This leads to increasing strain on CPU resources and decreasing density of first-hand annotation. RESULTS: These problems are addressed by clustering closely similar sequences to yield a covering of sequence space by a representative subset of sequences. No pair of sequences in the representative set has &gt;90% mutual sequence identity. The representative set is derived by an exhaustive search for close similarities in the sequence database in which the need for explicit sequence alignment is significantly reduced by applying deca- and pentapeptide composition filters. The algorithm was applied to the union of the Swissprot, Swissnew, Trembl, Tremblnew, Genbank, PIR, Wormpep and PDB databases. The all-against-all comparison required to generate a representative set at 90% sequence identity was accomplished in 2 days CPU time, and the removal of fragments and close similarities yielded a size reduction of 46%, from 260 000 unique sequences to 140 000 representative sequences. The practical implications are (i) faster homology searches using, for example, Fasta or Blast, and (ii) unified annotation for all sequences clustered around a representative. As tens of thousands of sequence searches are performed daily world-wide, appropriate use of the non-redundant database can lead to major savings in computer resources, without loss of efficacy. AVAILABILITY: A regularly updated non-redundant protein sequence database (nrdb90), a server for homology searches against nrdb90, and a Perl script (nrdb90.pl) implementing the algorithm are available for academic use from http://www.embl-ebi.ac. uk/holm/nrdb90. CONTACT: holm@embl-ebi.ac.uk
Uniform integration of genome mapping data using intersection
graphs
Authors: Harley Eric , Bonner Anthony , Goodman Nathan 
Published: July 2002

Abstract
Motivation: The methods for analyzing overlap data are distinct from those for analyzing probe data, making integration of the two forms awkward. Conversion of overlap data to probe-like data elements would facilitate comparison and uniform integration of overlap data and probe data using software developed for analysis of STS data.
Results: We show that overlap data can be effectively converted to probe-like data elements by extracting maximal sets of mutually overlapping clones. We call these sets virtual probes , since each set determines a site in the genome corresponding to the region which is common among the clones of the set. Finding the virtual probes is equivalent to finding the maximal cliques of a graph. We modify a known maximal-clique algorithm such that it finds all virtual probes in a large dataset within minutes. We illustrate the algorithm by converting fingerprint and Alu-PCR overlap data to virtual probes. The virtual probes are then analyzed using double-linkage intersection graphs and structure graphs to show that methods designed for STS data are also applicable to overlap data represented as virtual probes. Next we show that virtual probes can produce a uniform integration of different kinds of mapping data, in particular STS probe data and fingerprint and Alu-PCR overlap data. The integrated virtual probes produce longer double-linkage contigs than STS probes alone, and in conjunction with structure graphs they facilitate the identification and elimination of anomalies. Thus, the virtual-probe technique provides: (i) a new way to examine overlap data; (ii) a basis on which to compare overlap data and probe data using the same systems and standards; and (iii) a unique and useful way to uniformly integrate overlap data with probe data.
Availability: Freely available on request.
Contact: eharley@cs.toronto.edu
Positional Candidate Cloning of a QTL in Dairy Cattle: Identification of a Missense Mutation in the Bovine DGAT1 Gene with Major Effect on Milk Yield and Composition
Authors: Grisart Bernard , Coppieters Wouter , Farnir Frédéric , Karim Latifa , Ford Christine , Berzi Paulette , Cambisano Nadine , Mni Myriam , Reid Suzanne , Simon Patricia , Spelman Richard , Georges Michel , Snell Russell 
Published: July 2002

We recently mapped a quantitative trait locus (QTL) with a major effect on milk composition—particularly fat content—to the centromeric end of bovine chromosome 14. We subsequently exploited linkage disequilibrium to refine the map position of this QTL to a 3-cM chromosome interval bounded by microsatellite markers BULGE13and BULGE09. We herein report the positional candidate cloning of this QTL, involving (1) the construction of a BAC contig spanning the corresponding marker interval, (2) the demonstration that a very strong candidate gene, acylCoA:diacylglycerol acyltransferase (DGAT1), maps to that contig, and (3) the identification of a nonconservative K232A substitution in the DGAT1 gene with a major effect on milk fat content and other milk characteristics.[The sequence data described in this paper have been submitted to the GenBank data library under accession number AY065621.]
Effectiveness of Simulation-Based Training on Transesophageal Echocardiography Learning
Authors: Pezel Théo , Dreyfus Julien , Mouhat Basile , Thébaut Clémence , Audureau Etienne , Bernard Anne , Badie Yoan Lavie , Bohbot Yohann , Fard Damien , Nguyen Lee S. , Monteil Cécile , Bière Loïc , Le Ven Florent , Canu Marjorie , Ribeyrolles Sophie , Mion Baptiste , Bazire Baptiste , Fauvel Charles , Cautela Jennifer , Cambet Théo , Le Tourneau Thierry , Donal Erwan , Lafitte Stéphane , Magne Julien , Mansencal Nicolas , Coisne Augustin ,   SIMULATOR investigators, Aghezzaf Samy , Blanchard Virginie , Meilhac Alexandra 
Published: January 2023

Trial RegistrationClinicalTrials.gov Identifier: NCT05564507
The relationship between leisure-time physical activity and job satisfaction: A dynamic panel data approach
Authors: Dallmeyer Sören , Wicker Pamela , Breuer Christoph 
Published: January 2023

Abstract

Objective
Previous research has documented a positive effect of leisure-time physical activity (LTPA) on life satisfaction. The relationship between physical activity and the specific domain of job satisfaction is, however, relatively unknown. This study aims to investigate the effects of different frequency levels of LTPA on self-reported job satisfaction and specifically focuses on the two mechanisms of health and recovery from work stress.

Methods
Using data from the German Socio-Economic Panel (2001-2019), fixed effects and dynamic panel data regression models are estimated to address the problems of unobserved heterogeneity and reverse causality. A mediation and sub-sample analysis shed light on the role of health and work stress.

Results
The results reveal that weekly LTPA has a positive effect on job satisfaction and that health represents a channel yielding those benefits. The effect appears to be moderated by work stress. Further, the analysis reveals the importance of considering unobserved heterogeneity and reverse causality when studying this relationship.

Conclusion
The findings indicate a positive relationship between regular LTPA and job satisfaction and add plausible causal evidence to the limited literature in this context. The findings yield implications for employers and employees.
Clinicoradiologic data of familial cerebral cavernous malformation with age‐related disease burden
Authors: Kim Seondeuk , Moon Jangsup , Jung Keun‐Hwa , Ahn Seon‐Jae , Lee Han Sang , Jang Yoonhyuk , Park Kyung‐Il , Lee Sang Kun , Chu Kon 
Published: January 2023

AbstractObjectiveFamilial cerebral cavernous malformation (FCCM) is an autosomal dominant disease induced by loss‐of‐function mutations in three CCM genes, KRIT1, CCM2, and PDCD10. However, previous studies paid little attention to analyzing the radiologic features and age‐related disease burden according to the genes. Therefore, we retrospectively reviewed the genetic tests of our center's clinical FCCM patients.MethodThis study investigated clinical FCCM patients with multiple lesions or a family history of CCMs who underwent the FCCM gene (KRTI1, CCM2, and PDCD10) panel test. The clinical, genetic, and radiologic features were analyzed.ResultAmong the patients (n = 34) undergoing the FCCM gene test, twenty‐seven patients had CCM confirmed by brain MRI, and twenty‐one patients were considered to have FCCM (cohort 1). In cohort 1, thirteen patients had mutations in the FCCM gene, but eight did not. Cohort 2 comprised cohort 1 and four family members with the same mutation as the probands. Six novel variants in CCM genes were detected (KRIT1 c.22_26del, c.815dup, c.1094_1098del, c.1147‐2A>G, c.2124dup, and PDCD10 c.150 + 1dup). Cohort 1 demonstrated that brainstem lesions were mostly associated with the mutation detection in CCM genes (brainstem, lateral temporal, and parietal lesions vs. lateral temporal and parietal lesions, AUC 0.928 vs. 0.779, P = 0.0389). The radiologic severity worsened according to age in the KRIT1 group compared with the Mutation not detected group (correlation coefficient 0.75 (P < 0.001) versus 0.53 (P = 0.004)).ConclusionThe brainstem lesion could be the radiologic marker for FCCM with the mutation detected. The age‐related disease burden regarding FCCM according to genetic information was demonstrated.
Enhanced Spin Current in Ni81Fe19/Cu–CuOx Bilayer with Top and Sideways Oxidization
Authors: An Taiyu , Cui Bin , Liu Liang , Zhang Mingfang , Liu Fufu , Liu Weikang , Xie Jihao , Ren Xue , Chu Ruiyue , Cheng Bin , Jiang Changjun , Hu Jifan 
Published: January 2023

AbstractGeneration and manipulation of spin current are the cores of spintronic devices, which are intensely pursued. Heavy metals with strong spin–orbit coupling are commonly used for the generation of spin current, but are incompatible with the mass production of devices, and the polarization of spin current is limited to be in‐plane. Here, it is shown that the spin current with strong out‐of‐plane polarization component can be generated and transmitted in Ni81Fe19/Cu–CuOx bilayer with sideways and top oxidizations. The charge‐to‐spin current conversion efficiency can be enhanced through the spin currents consisting of both out‐of‐plane polarization (σz) and in‐plane polarization (σy) induced by spin‐vorticity coupling. Such a spin current is demonstrated to be closely related to the lateral oxidization gradient and can be controlled by changing the temperatures and times of annealing. The finding here provides a novel degree of freedom to produce and control the spin current in spintronic devices.
Rational Design of Polymethine Dyes with NIR‐II Emission and High Photothermal Conversion Efficiency for Multimodal‐Imaging‐Guided Photo‐Immunotherapy
Authors: Ran Xiao‐Yun , Chen Ping , Liu Yan‐Zhao , Shi Lei , Chen Xue , Liu Yan‐Hong , Zhang Hong , Zhang Li‐Na , Li Kun , Yu Xiao‐Qi 
Published: January 2023

AbstractPhototheranostics have emerged and flourished as a promising pattern for cancer theranostics owing to their precise photoinduced diagnosis and therapeutic to meet the demands of precision medicine. The diagnosis information and therapeutic effect are directly determined by the fluorescence imaging ability and photothermal conversion efficiency (PCE) of phototheranostic agents. Hence, how to balance the competitive radiative and nonradiative processes of phototheranostic agents is the key factor to evaluate the phototheranostic effect. Herein, molecules named ICRs with high photostaibility are rationally designed, exhibiting fluorescence emission in the second near‐infrared window (NIR‐II, 1000–1700 nm) and high PCE, which are related to the strong donor–acceptor (D–A) interaction and high reorganization energy Noteworthily, ICR‐Qu with stronger D–A interaction and a large‐sized conjugated unit encapsulated in nanoparticles exhibits high PCE (81.1%). In addition, ICR‐QuNPs are used for fluorescence imaging (FLI), photoacoustic imaging (PAI), and photothermal imaging (PTI) to guide deep‐tissue photonic hyperthermia, achieving precise removal and inhibition of breast cancer. Furthermore, combined with α‐PD‐1, ICR‐QuNPs show huge potential to be a facile and efficient tool for photo‐immunotherapy. More importantly, this study not only reports an “all‐in‐one” polymethine‐based phototheranostic agent, but also sheds light on the exploration of versatile organic molecules for future practical applications.
High Durability of Fe–N–C Single‐Atom Catalysts with Carbon Vacancies toward the Oxygen Reduction Reaction in Alkaline Media
Authors: Tian Hao , Song Ailing , Zhang Peng , Sun Kaian , Wang Jingjing , Sun Bing , Fan Qiaohui , Shao Guangjie , Chen Chen , Liu Hao , Li Yadong , Wang Guoxiu 
Published: January 2023

AbstractSingle‐atom catalysts (SACs) have attracted extensive interest to catalyze the oxygen reduction reaction (ORR) in fuel cells and metal–air batteries. However, the development of SACs with high selectivity and long‐term stability is a great challenge. In this work, carbon vacancy modified Fe–N–C SACs (FeH–N–C) are practically designed and synthesized through microenvironment modulation, achieving high‐efficient utilization of active sites and optimization of electronic structures. The FeH–N–C catalyst exhibits a half‐wave potential (E1/2) of 0.91 V and sufficient durability of 100 000 voltage cycles with 29 mV E1/2 loss. Density functional theory (DFT) calculations confirm that the vacancies around metal–N4 sites can reduce the adsorption free energy of OH*, and hinder the dissolution of metal center, significantly enhancing the ORR kinetics and stability. Accordingly, FeH–N–C SACs presented a high‐power density and long‐term stability over 1200 h in rechargeable zinc–air batteries (ZABs). This work will not only guide for developing highly active and stable SACs through rational modulation of metal–N4 sites, but also provide an insight into the optimization of the electronic structure to boost electrocatalytical performances.
The Shuttle of Sulfur Dioxide: Iridium/Copper‐Cocatalyzed Trifluoromethylfluorosulfonylation of Alkenes
Authors: Yang Yi‐Fei , Xiao Fang , Lin Jin‐Hong , Xiao Ji‐Chang 
Published: January 2023

AbstractDepending on the nature of the attached functional moiety, the sulfonyl radical can either undergo an automatic SO2 liberation or react directly as the thermodynamically favored sulfonyl radical. Taking advantage of this unique property, we envisioned that through rational reaction design, the in situ release and re‐insertion of SO2, i. e., the shuttle of SO2, can be realized. Herein we report our recent progress in copper metallaphotoredox co‐catalyzed trifluoromethyl‐fluorosulfonylation of alkenes with TFSP as both the CF3 and SO2 source. Valuable functional groups are added across the double bonds. Besides, A wide array of synthetically useful moieties featuring distinct electronic patterns and various nitrogenous heterocycles are well tolerated by this strategy.magnified image
Correlation between Nanoscale Domain Structures and Superconducting Phase Transitions in Highly Crystalline 2D Superconductors
Authors: Wang Libin , Xu Chuan , Liu Zhen , Liu Zhibo , Yang Zixuan , Cheng Hui‐Ming , Ren Wencai , Kang Ning 
Published: January 2023

AbstractThe domains and domain boundaries in 2D materials are known to play essential roles in investigating intriguing physical properties and have potential applications in nanoscale devices. Understanding the influence of individual domains on the superconducting properties of ultrathin 2D superconductors is of crucial importance for fundamental studies on mesoscopic superconductivity as well as applications in superconducting nanoelectronics. Here, low‐temperature electronic transport measurements of high quality ultrathin Mo2C crystals are presented that show clear evidence for the presence of multiple superconducting phase induced by the nanoscale domain structures. In particular, the observation of an anomalous resistance peak in the vicinity of the onset of the superconducting transition is reported. This resistive anomaly is interpreted as a consequence of nonequilibrium charge imbalance near the domain boundaries, which could induce effective normal‐superconducting interfaces in 2D Mo2C crystals. Moreover, the magnetic field‐tuned superconductor‐metal transition for ultrathin Mo2C crystals is examined. The observed scaling behavior is consistent with the appearance of quantum Griffiths singularity in 2D superconducting systems. This study sheds light on the understanding of the domain boundaries and their role on the transport properties of highly crystalline 2D superconductors, which may open potential application of domain structure in functional superconducting nanodevices.
Observation of Weak Counterion Size Dependence of Thermoelectric Transport in Ion Exchange Doped Conducting Polymers Across a Wide Range of Conductivities
Authors: Chen Chen , Jacobs Ian E. , Kang Keehoon , Lin Yue , Jellett Cameron , Kang Boseok , Lee Seon Baek , Huang Yuxuan , BaloochQarai Mohammad , Ghosh Raja , Statz Martin , Wood William , Ren Xinglong , Tjhe Dion , Sun Yuanhui , She Xiaojian , Hu Yuanyuan , Jiang Lang , Spano Frank C. , McCulloch Iain , Sirringhaus Henning 
Published: January 2023

AbstractConducting polymers are of interest for a broad range of applications from bioelectronics to thermoelectrics. The factors that govern their complex charge transport physics include the structural disorder present in these highly doped polymer films and the Coulombic interactions between the electronic charge carriers and the dopant counterions. Previous studies have shown that at low doping levels carriers are strongly trapped in the vicinity of the counterions, while at high doping levels charge transport is not limited by Coulombic trapping, which manifests itself in the conductivity being independent of the size of the dopant counterion. Here a recently developed ion exchange doping method is used to investigate the ion size dependence of a semicrystalline polythiophene‐based model system across a wide range of conductivities. It is found that the regime in which the charge and thermoelectric transport is not or only weakly dependent on ion size, extends to surprisingly low conductivities. This surprising observation is explained by a heterogeneous doping that involves doping of the amorphous domains to high doping levels first before doping of the ordered, crystalline domains occurs. The study provides new insights into how the thermoelectric physics of conducting polymers evolves as a function of doping level.
Checkpoint inhibitor‐based salvage regimens prior to autologous stem cell transplant improve event‐free survival in relapsed/refractory classic Hodgkin lymphoma
Authors: Desai Sanjal H. , Spinner Michael A. , David Kevin , Bachanova Veronika , Goyal Gaurav , Kahl Brad , Dorritie Kathleen , Azzi Jacques , Kenkre Vaishalee P. , Arai Sally , Chang Cheryl , Fusco Brendon , Sumransub Nuttavut , Hatic Haris , Saba Raya , Ibrahim Uroosa , Harris Elyse I. , Shah Harsh , Murphy Jacob , Ansell Stephen , Jagadish Deepa , Orellana‐noia Victor , Diefenbach Catherine , Iyenger Siddharth , Rappazzo K. C. , Mishra Rahul , Choi Yun , Nowakowski Grzegorz S. , Advani Ranjana H. , Micallef Ivana N. 
Published: January 2023

AbstractClinical trials of novel salvage therapies have encouraging outcomes for relapsed/refractory transplant‐eligible classic Hodgkin lymphoma (R/R cHL) but comparison with conventional chemotherapy is lacking. Herein, we report the final analysis of a multicenter retrospective cohort of R/R cHL assessing outcomes by type of salvage therapy before autologous stem cell transplant (ASCT). R/R cHL patients who underwent ASCT at 14 institutions across the United States were included. Outcomes were compared among patients receiving conventional chemotherapy, brentuximab vedotin (BV) + chemotherapy, BV alone, and a checkpoint inhibitor (CPI)‐based regimens before ASCT. Study endpoints included event‐free survival (EFS), progression‐free survival (PFS), and overall survival (OS). All endpoints are defined from relapse. Of 936 patients, 728 received conventional chemotherapy, 73 received BV + chemotherapy, 70 received BV alone, and 65 received CPI‐based regimens prior to ASCT. When adjusted for time to relapse, pre‐ASCT response and use of BV maintenance, patients receiving CPI‐based regimens had superior 2‐year EFS compared to conventional chemotherapy, BV + chemotherapy, and BV alone (79.7, 49.6, 62.3, and 36.9%, respectively, p < .0001). Among 649 patients transplanted after 1 line of salvage therapy, CPI‐based regimens were associated with superior 2‐year PFS compared to conventional chemotherapy (98% vs. 68.8%, hazard ratio: 0.1, 95% confidence interval: 0.03–0.5, p < .0001). OS did not differ by pre‐ASCT salvage regimen. In this large multicenter retrospective study, CPI‐based regimens improved EFS and PFS compared to other salvage regimens independent of pre‐ASCT response. These data support earlier sequencing of CPI‐based regimens in R/R cHL in the pre‐ASCT setting.