bluuebunny/crossref_metadata_2025_split huggingface dataset:
The interrelations between psychological outcome trajectories and resource changes amid large-scale disasters: A growth mixture modeling analysis
Authors: Tao Tiffany Junchen , Liang Li , Liu Huinan , Hobfoll Stevan E. , Hou Wai Kai , Bonanno George A. 
Published: February 2023

AbstractCurrently little is known about the interrelations between changes in psychiatric symptoms and changes in resources (personal, social, financial) amid large-scale disasters. This study investigated trajectories of psychiatric symptoms and their relationships with different patterns of changes in personal, social, and financial resources between 2020 and 2022 amid the COVID-19 pandemic. A population-representative sample (N = 1333) was recruited to complete self-report instruments at the pandemic’s acute phase (February–July 2020, T1), and again at 1-year (March–August 2021, T2) and 1.5-year (September 2021–February 2022, T3) follow-ups. Respondents reported depressive and anxiety symptoms, self-efficacy, perceived social support, and financial capacity. Growth mixture modeling (GMM) identified four trajectories of depressive and anxiety symptoms: resilience (72.39–74.19%), recovery (8.40–11.93%), delayed distress (7.20–7.35%), and chronic distress (8.33–10.20%). Four patterns were demonstrated in resource changes: persistent high resources (40.89–47.64%), resource gain (12.08–15.60%), resource loss (6.30–10.43%), and persistent low resources (28.73–36.61%). Loss and gain in financial resources characterized chronic distress and resilience, respectively. Loss in personal resources characterized delayed distress, whereas loss or no gain in social resources was related to chronic/delayed distress. Respondents in resilience were also more likely to have persistent high resources while those with delayed/chronic distress were more likely to have persistent low resources. These results provide an initial evidence base for advancing current understanding on trajectories of resilience and psychopathology in the context of resource changes during and after large-scale disasters.
Targeting tumor-associated macrophages in hepatocellular carcinoma: biology, strategy, and immunotherapy
Authors: Zheng Hongyu , Peng Xueqiang , Yang Shuo , Li Xinyu , Huang Mingyao , Wei Shibo , Zhang Sheng , He Guangpeng , Liu Jiaxing , Fan Qing , Yang Liang , Li Hangyu 
Published: February 2023

AbstractHepatocellular carcinoma (HCC), one of the most malignant tumors, is characterized by its stubborn immunosuppressive microenvironment. As one of the main members of the tumor microenvironment (TME) of HCC, tumor-associated macrophages (TAMs) play a critical role in its occurrence and development, including stimulating angiogenesis, enhancing immunosuppression, and promoting the drug resistance and cancer metastasis. This review describes the origin as well as phenotypic heterogeneity of TAMs and their potential effects on the occurrence and development of HCC and also discusses about various adjuvant therapy based strategies that can be used for targeting TAMs. In addition, we have highlighted different treatment modalities for TAMs based on immunotherapy, including small molecular inhibitors, immune checkpoint inhibitors, antibodies, tumor vaccines, adoptive cellular immunotherapy, and nanocarriers for drug delivery, to explore novel combination therapies and provide feasible therapeutic options for clinically improving the prognosis and quality of life of HCC patients.
Less extreme and earlier outbursts of ice-dammed lakes since 1900
Authors: Veh Georg , Lützow Natalie , Tamm Jenny , Luna Lisa V. , Hugonnet Romain , Vogel Kristin , Geertsema Marten , Clague John J. , Korup Oliver 
Published: February 2023

AbstractEpisodic failures of ice-dammed lakes have produced some of the largest floods in history, with disastrous consequences for communities in high mountains1–7. Yet, estimating changes in the activity of ice-dam failures through time remains controversial because of inconsistent regional flood databases. Here, by collating 1,569 ice-dam failures in six major mountain regions, we systematically assess trends in peak discharge, volume, annual timing and source elevation between 1900 and 2021. We show that extreme peak flows and volumes (10 per cent highest) have declined by about an order of magnitude over this period in five of the six regions, whereas median flood discharges have fallen less or have remained unchanged. Ice-dam floods worldwide today originate at higher elevations and happen about six weeks earlier in the year than in 1900. Individual ice-dammed lakes with repeated outbursts show similar negative trends in magnitude and earlier occurrence, although with only moderate correlation to glacier thinning8. We anticipate that ice dams will continue to fail in the near future, even as glaciers thin and recede. Yet widespread deglaciation, projected for nearly all regions by the end of the twenty-first century9, may bring most outburst activity to a halt.
Heterogeneous melting near the Thwaites Glacier grounding line
Authors: Schmidt B. E. , Washam P. , Davis P. E. D. , Nicholls K. W. , Holland D. M. , Lawrence J. D. , Riverman K. L. , Smith J. A. , Spears A. , Dichek D. J. G. , Mullen A. D. , Clyne E. , Yeager B. , Anker P. , Meister M. R. , Hurwitz B. C. , Quartini E. S. , Bryson F. E. , Basinski-Ferris A. , Thomas C. , Wake J. , Vaughan D. G. , Anandakrishnan S. , Rignot E. , Paden J. , Makinson K. 
Published: February 2023

AbstractThwaites Glacier represents 15% of the ice discharge from the West Antarctic Ice Sheet and influences a wider catchment1–3. Because it is grounded below sea level4,5, Thwaites Glacier is thought to be susceptible to runaway retreat triggered at the grounding line (GL) at which the glacier reaches the ocean6,7. Recent ice-flow acceleration2,8 and retreat of the ice front8–10 and GL11,12 indicate that ice loss will continue. The relative impacts of mechanisms underlying recent retreat are however uncertain. Here we show sustained GL retreat from at least 2011 to 2020 and resolve mechanisms of ice-shelf melt at the submetre scale. Our conclusions are based on observations of the Thwaites Eastern Ice Shelf (TEIS) from an underwater vehicle, extending from the GL to 3 km oceanward and from the ice–ocean interface to the sea floor. These observations show a rough ice base above a sea floor sloping upward towards the GL and an ocean cavity in which the warmest water exceeds 2 °C above freezing. Data closest to the ice base show that enhanced melting occurs along sloped surfaces that initiate near the GL and evolve into steep-sided terraces. This pronounced melting along steep ice faces, including in crevasses, produces stratification that suppresses melt along flat interfaces. These data imply that slope-dependent melting sculpts the ice base and acts as an important response to ocean warming.
The effect of long-range interactions on the infrared and Raman spectra of aragonite (CaCO3, Pmcn) up to 25 GPa
Authors: Ulian Gianfranco , Valdrè Giovanni 
Published: February 2023

AbstractLong-range interactions are relevant in the physical description of materials, even for those where other stronger bonds give the leading contributions. In this work, we demonstrate this assertion by simulating the infrared and Raman spectra of aragonite, an important calcium carbonate polymorph (space groupPmcn) in geological, biological and materials science fields. To this aim, we used Density Functional Theory methods and two corrections to include long-range interactions (DFT-D2 and DFT-D3). The results were correlated to IR spectroscopy and confocal Raman spectrometry data, finding a very good agreement between theory and experiments. Furthermore, the evolution of the IR/Raman modes up to 25 GPa was described in terms of mode-Grüneisen’s parameters, which are useful for geological and materials science applications of aragonite. Our findings clearly show that weak interactions are of utmost importance when modelling minerals and materials, even when they are not the predominant forces.
A straightforward method to quantify circulating mRNAs as biomarkers of colorectal cancer
Authors: Grosgeorges Marie , Picque Lasorsa Laurence , Pastor Brice , Prévostel Corinne , Crapez Evelyne , Sanchez Cynthia , Frayssinoux Florence , Jarlier Marta , Pezzella Véronique , Monard Laure , Ychou Marc , Thierry Alain R. , Mazard Thibault , Blache Philippe 
Published: February 2023

AbstractOptimizing the biomarker combination to be analyzed in liquid biopsies should improve personalized medicine. We developed a method to purify circulating cell-free mRNAs from plasma samples and to quantify them by RT-qPCR. We selected three candidate colorectal cancer biomarkers (B2M, TIMP-1, and CLU). Their mRNA levels were significantly higher in plasma of patients with metastatic colorectal cancer patients (mCRC) (n = 107) than in healthy individuals (HI) (n = 53). To increase the discriminating performance of our method, we analyzed the sum of the three mRNA levels (BTC index). The area under the ROC curve (AUC) to estimate the BTC index capacity to discriminate between mCRC and HI plasma was 0.903. We also determined the optimal BTC index cut-off to distinguish between plasma samples, with 82% of sensitivity and 93% of specificity. By using mRNA as a novel liquid biopsy analytical parameter, our method has the potential to facilitate rapid screening of CRCm.
Comprehensive survey of ternary full adders: Statistics, corrections, and assessments
Authors: Nemati Sarina , Haghi Kashani Mostafa , Faghih Mirzaee Reza 
Published: February 2023

AbstractThe history of ternary adders goes back to more than 6 decades ago. Since then, a multitude of ternary full adders (TFAs) have been presented in the literature. This article conducts a review of TFAs so that one can be familiar with the utilised design methodologies and their prevalence. Moreover, despite numerous TFAs, almost none of them are in their simplest form. A large number of transistors could have been eliminated by considering a partial TFA instead of a complete one. According to our investigation, only 28.6% of the previous designs are partial TFAs. Also, they could have been simplified even further by assuming a partial TFA with an output carry voltage of 0 V or VDD. This way, in a single‐VDD design, voltage division inside the Carry generator part would have been eliminated and less power dissipated. As far as we have searched, there are only three partial TFAs with this favourable condition in the literature. Additionally, most of the simulation setups in the previous articles are not realistic enough. Therefore, the simulation results reported in these papers are neither comparable nor entirely valid. Therefore, the authors got motivated to conduct a survey, elaborate on this issue, and enhance some of the previous designs. Among 84 papers, 10 different TFAs (from 11 papers) are selected, simplified, and simulated in this article. Simulation results by HSPICE and 32 nm carbon nanotube FET technology reveal that the simplified partial TFAs outperform their original versions in terms of delay, power, and transistor count.
Analysis of sub‐synchronous resonance between DC‐side dynamics of large‐scale PV plants and nearby synchronous generators shaft
Authors: Pourheydari Mohammad , Parniani Mostafa , Ravanji Mohammad Hasan 
Published: February 2023

AbstractThis paper investigates the dynamic interactions between large‐scale PV plants and nearby synchronous generators. To this end, a comprehensive model of a PV plant, including the PV arrays characteristic and their voltage controller, DC/DC converter, DC‐link dynamic, DC/AC inverter controllers, and output filter, is obtained. Then, the eigenvalues of the PV plant model are calculated, and it is revealed that the PV plant has a dynamic mode in the sub‐synchronous oscillations (SSOs) range. Furthermore, the modal analysis method is employed, and it is shown that the inductance of the DC/DC converter and the DC‐link capacitor significantly contribute to the PV sub‐synchronous mode. Also, it is shown that this mode oscillations penetrate the grid and increase the risk of sub‐synchronous resonance (SSR). Then, the mechanism of dynamic interactions between large‐scale PV plants and torsional modes of nearby synchronous generators is revealed. This paper also investigates the required conditions for these interactions and shows that solar irradiation level and the DC‐link capacitance are the essential factors that can intensify these interactions.
Assessment and enhancement control for small‐signal voltage stability of VSC‐HVDC systems supplying passive industrial loads
Authors: Xue Yicheng , Zhang Zheren , Hua Wen , Wang Guoteng , Xu Zheng , Dong Wei 
Published: February 2023

AbstractThis paper presents a comprehensive assessment for the small‐signal voltage stability of voltage source converter (VSC)‐HVDC systems supplying industrial loads represented by the induction motors (IMs) and provides a stability enhancement control for the VSCs. First, the steady‐state voltage stability is analysed to seek the factors that affect the existence of the stable equilibrium point. Then, the small‐signal voltage stability analysis is performed based on the developed linear model. Eigenvalue analysis is carried out to capture the critical factors that induce instability phenomena correlative to the system voltage. It demonstrates that decreasing either the proportional gain K of the VSC's PI controller or the electrical distance between the VSC and IM is detrimental to voltage stability. Next, the enhancement control strategy is elaborated. It adopts virtual reactance and virtual admittance control for the VSC to improve the voltage control capability. Finally, the effectiveness and robustness of the proposed enhancement control are validated via time‐domain simulations in a multi‐IM system supplied by VSC‐HVDC.
Dielectric response—A nondestructive approach to probing the micro‐interface of aluminium hydroxide filled silicone rubber composites for outdoor insulation
Authors: Wu Chao , Dissado Leonard Alexander , Gao Yanfeng , Wang Qian , Liu Yingyan , Cao Yang , Liang Xidong 
Published: February 2023

AbstractComposite polymer dielectrics have strong electrical, mechanical, thermal and environmental properties but experience both high electric fields and harsh environmental conditions as outdoor insulation. The present investigation of the stress‐strain characteristics and morphology of the fracture cross‐section reveal the risk of a weakly bonded interface between the aluminium hydroxide (ATH) filler and silicone rubber used for insulators in transmission lines and substations. Dielectric response measurements are proposed as a non‐destructive probe of the interface quality. An analysis, based on the Dissado–Hill model, indicated that the introduction of ATH interfaces gave rise to a quasi‐DC process, in which charge transport is in the form of hopping along the weakly bonded interfaces. A schematic plan is proposed that would allow such an analysis to be used to obtain quantitative information correlated to the status of the weakly bonded interface for the diagnosis of micro‐interface quality in ATH‐filled silicone rubber and dielectric composites in general.
TransMVU: Multi‐view 2D U‐Nets with transformer for brain tumour segmentation
Authors: Liu Zengxin , Ma Caiwen , She Wenji , Wang Xuan 
Published: February 2023

AbstractMedical image segmentation remains particularly challenging for complex and low‐contrast anatomical structures, especially in brain MRI glioma segmentation. Gliomas appear with extensive heterogeneity in appearance and location on brain MR images, making robust tumour segmentation extremely challenging and leads to highly variable even in manual segmentation. U‐Net has become the de facto standard in medical image segmentation tasks with great success. Previous researches have proposed various U‐Net‐based 2D Convolutional Neural Networks (2D‐CNN) and their 3D variants, called 3D‐CNN‐based architectures, for capturing contextual information. However, U‐Net often has limitations in explicitly modelling long‐term dependencies due to the inherent locality of convolution operations. Inspired by the recent success of natural language processing transformers in long‐range sequence learning, a multi‐view 2D U‐Nets with transformer (TransMVU) method is proposed, which combines the advantages of transformer and 2D U‐Net. On the one hand, the transformer encodes the tokenized image patches in the CNN feature map into an input sequence for extracting global context for global feature modelling. On the other hand, multi‐view 2D U‐Nets can provide accurate segmentation with fewer parameters than 3D networks. Experimental results on the BraTS20 dataset demonstrate that our model outperforms state‐of‐the‐art 2D models and classic 3D model.
Single‐switch coupled‐inductors‐based high step‐up converter with reduced voltage stress
Authors: Khalili Siamak , Ahmadi Amir Abbas , Adib Ehsan , Golsorkhi Mohammad Sadegh 
Published: February 2023

AbstractThis paper proposes a non‐isolated DC‐DC high step‐up converter. To achieve a high voltage conversion ratio and overcome the problems related to near unity duty‐cycle of the conventional boost converter in high step‐up applications, coupled‐inductors along with switch‐capacitor techniques are merged in this topology. The proposed converter provides continuous input current with low ripple without using any current ripple cancellation method and the voltage across the switch is limited inherently. In order to reduce the control circuit complexity, the proposed converter uses only one switch. These features decrease the complexity of the proposed converter structure. The voltage stress of the semiconductor components is reduced significantly; thus, high‐quality elements (fast power MOSFET switches with low on‐state resistance and Schottky diodes with low forward voltage drop along with low power losses) can be used, which minimizes the switching and conduction losses and improves the converter efficiency. To confirm the converter operation and theoretical analysis, a 200‐W prototype converter with 24‐to‐200‐V input and output voltages operating at 100‐kHz is implemented in the laboratory.
WHO-Leitlinie: Leitfaden für die medikamentöse
Behandlung von Bluthochdruck bei Erwachsenen
Authors: Moick Sigrid , Sommer Isolde , Gartlehner Gerald 
Published: February 2023

Zusammenfassung
Hintergrund Jedes Jahr sterben mehr Menschen an
Herz-Kreislauf-Erkrankungen (HKE) als an jeder anderen Todesursache. Hypertonie,
also Bluthochdruck, erhöht das Risiko für
kardiovaskuläre, cerebrale, renale und andere Krankheiten erheblich.
Ziel Diese WHO-Leitlinie gibt aktuellste Empfehlungen zur
medikamentösen Behandlung von erwachsenen Personen mit Bluthochdruck.
Diese Übersetzung gibt einen Überblick der WHO-Leitlinie und
fasst die wichtigsten Empfehlungen zusammen.
Methode Die Leitlinie 2021 wurde von der Weltgesundheitsorganisation (WHO)
gemäß WHO-Standards umgesetzt. Die Zusammenfassung wurde von
MitarbeiterInnen des WHO Collaborating Centres für Evidenzbasierte
Medizin an der Universität für Weiterbildung Krems
(Österreich) auf Deutsch übersetzt.
Ergebnisse Die WHO gibt Empfehlungen zum Grenzwert des Bluthochdrucks
für die Einleitung einer medikamentösen Behandlung, zur
Durchführung von Untersuchungen vor Behandlungsbeginn, zur Therapie-
bzw. Medikamentenwahl, zum Zielblutdruck sowie zur Verlaufskontrolle und
Behandlung durch nicht-ärztliche Fachkräfte.
Schlussfolgerungen Diese evidenzbasierte globale Public-Health-Leitlinie
der WHO erfasst die aktuellsten und wichtigsten Empfehlungen zur
medikamentösen Behandlung von Bluthochdruck bei Erwachsenen.
Haare oder Luft – klinischer Schnappschuss einer Alopezie unter NIV-Maske
Authors: Knoop Heiko , Schöbel Christoph , Knoop Umut , Kreuter Alexander 
Published: February 2023

ZusammenfassungUnter Nutzung einer NIV-Maske kam es zur Entwicklung einer Alopezia areata.
The Effect of Music on Balance Parameters
Authors: Unver Fatma , Buke Meryem 
Published: February 2023

Abstract
Objectives This study aimed to determine the effect of music on balance
parameters in healthy individuals.
Methods Forty-two participants were included in the study, mean
age=23.3 (SD=5.31). Prokin Tecnobody balance device was used for
balance measurements. Static and dynamic balance measurements on the dominant
foot and bipedal stance were recorded while listening to high-intensity music
and without music.
Results In the study, there was a statistically significant difference in
the dominant foot static mediolateral balance in measurements taken with music
(p=0.013). But, there was no difference in other parameters
(p>0.05). When examined by gender, it was found that the mediolateral
balance scores of females on static and dynamic dominant feet were significantly
higher in high-intensity music than males (p<0.05).
Conclusion In healthy participants, music improves the mediolateral
balance on the dominant foot. Therefore, high-intensity music can be a safe and
motivating method to be used in addition to clinical applications.
Synthesis of a Water-Soluble Tridentate (Dimethylamino)ethyl Cu(I)/Cu(II)-Ligand
Authors: Pietruszka Jörg , Weber T. Moritz 
Published: February 2023

AbstractCopper-catalyzed alkyne azide click chemistry (CuAAC) plays an important role in drug development and labeling of biological materials. Stabilizing ligands prevent Cu(I)-species from oxidation, increases the solubility of copper, and increases the acceleration of the catalyzed process. In this context, we report on the synthesis of a tris-amine tridentate Cu-ligand (TDETA), with terminal (dimethylamino)ethyl-substitution, which can be legally synthesized as a replacement of toxic nitrogen mustard HN3 as an intermediate and is a scalable alternative to the previously found amine ligand DTEA. The class II ligand TDETA exhibits excellent solubility properties in organic solvents and aqueous solutions, outcompetes the commercial class I ligands THPTA and TBTA for a broad range of azide and alkyne combinations using Cu(I)- and Cu(II)-species, and was shown to be recoverable in a yield of 80%.