bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intermittent Fasting induced ketogenesis inhibits mouse epithelial ovarian tumors by promoting anti-tumor T cell response
Authors: Udumula Mary Priyanka , Singh Harshit , Faraz Rashid , Poisson Laila , Tiwari Nivedita , Dimitrova Irina , Hijaz Miriana , Gogoi Radhika , Swenor Margaret , Munkarah Adnan , Giri Shailendra , Rattan Ramandeep 
Published: March 2023

AbstractEpithelial Ovarian Cancer (EOC) is the most lethal gynecologic cancer with limited genetic alterations identified that can be therapeutically targeted. In tumor bearing mice, short-term fasting, fasting mimicking diet and calorie restriction enhance the activity of antineoplastic treatment by modulating systemic metabolism and boosting anti-tumor immunity. We tested the outcome of sixteen-hour intermittent fasting (IF) on mouse EOC progression with focus on fasting driven antitumor immune responses. IF resulted in consistent decrease of tumor promoting metabolic growth factors and cytokines, recapitulating changes that creates a tumor antagonizing environment. Immune profiling revealed that IF profoundly reshapes anti-cancer immunity by inducing increase in CD4+and CD8+cells, paralleled by enhanced antitumor Th1 and cytotoxic responses, by enhancing their metabolic fitness. Metabolic studies revealed that IF generated bioactive metabolite BHB which can be a potential substitute for simulating the antitumor benefits of IF. However, in a direct comparison, IF surpassed exogenous BHB therapy in improving survival and activating anti-tumor immune response. Thus, our data provides strong evidence for IF and its metabolic mediator BHB for ameliorating EOC progression and as a viable approach in maintaining and sustaining an effective anti-tumor T cell response.
Dissection of the role of a SH3 domain in the evolution of binding preference of paralogous proteins
Authors: Lemieux Pascale , Bradley David , Dubé Alexandre K , Dionne Ugo , Landry Christian R 
Published: March 2023

AbstractProtein-protein interactions (PPIs) drive many cellular processes. Some PPIs are directed by Src homology 3 (SH3) domains that bind proline-rich motifs on other proteins. The evolution of the binding specificity of SH3 domains is not completely understood, particularly following gene duplication. Paralogous genes accumulate mutations that can modify protein functions and, for SH3 domains, their binding preferences. Here, we examined how the binding of the SH3 domains of two paralogous yeast type I myosins, Myo3 and Myo5, evolved following duplication. We found that the paralogs have subtly different SH3-dependent interaction profiles. However, by swapping SH3 domains between the paralogs and by characterizing the SH3 domains freed from their protein context, we find that very few of the differences in interactions, if any, depend on the SH3 domains themselves. We used ancestral sequence reconstruction to resurrect the pre-duplication SH3 domains and examined, moving back in time, how the binding preference changed. Although the closest ancestor of the two domains had a very similar binding preference as the extant ones, older ancestral domains displayed a gradual loss of interaction with the modern interaction partners when inserted in the extant paralogs. Molecular docking and experimental characterization of the free ancestral domains showed that their affinity with the proline motifs is likely not the cause for this loss of binding. Taken together, our results suggest that the SH3 and its host protein could create intramolecular or allosteric interactions essential for the SH3-dependent PPIs, making domains not functionally equivalent even when they have the same binding specificity.
BIRC5 Regulates IGFBP-3-Induced Autocrine Loop in Cancer Stem Cells
Authors: Kahm Yeon-Jee , Jung Uhee , Kim Rae-Kwon 
Published: March 2023

AbstractBaculoviral inhibitor of apoptosis repeat-containing 5 (BIRC5) is also known as survivin. BIRC5 is overexpressed in various carcinomas and is involved in cell growth and apoptosis. BIRC5, a member of the apoptosis inhibitor (IAP) family, negatively regulates apoptosis or programmed cell death by inhibiting caspase activation. Due to these properties, overexpression of BIRC5 enables specific survival and division associated with cancer malignancies. In addition, BIRC5 is highly expressed in stem cells, but not present at all in terminally differentiated cells. On this basis, there is speculation that BIRC5 may be involved in the regulation of cancer stem cells (CSCs), but few study results have been reported. In addition, the molecular mechanisms of BIRC5 regulation are not yet well understood. Through the present study, it was confirmed that BIRC5 is a key factor regulating CSCs and epithelial to mesenchymal transition (EMT) phenomena. BIRC5 was simultaneously overexpressed in lung cancer stem cells (LCSCs) and glioma stem cells (GSCs), and when the expression was suppressed, the characteristics of CSCs disappeared. In addition, IGFBP-3, a secreted factor regulated by BIRC5, is involved in signaling mechanisms that regulate cancer stem cells and EMT, and IGFBP-3 forms an autocrine chain. Based on these results, BIRC5 is proposed as a novel therapeutic target protein for LCSCs and GSCs.
Economics as a rhetorical language game
Authors: Almeida Raquel Mesquita 
Published: March 2023

PurposeThis paper aims to argue that Economics is not a neutral science.Design/methodology/approachPost-structuralist perspective of Lyotard (1984), alongside the Pragmatics of Searle (1979) and Travis (1981) are useful for analyzing enunciations in mainstream Economics.FindingsEconomists use illocutionary acts expressed in formal language to achieve perlocutionary effects. Because of the importance attached to objectivity in mainstream Economics, the use of artificial languages is preferred to natural language. However, formal language is preferred regarding its perlocutionary effects on economists' community.Originality/valueThis paper puts together the Continental and the Analytical Philosophy and show, in an original manner, how their intersections and how they can be useful to better understand the epistemology of Economics.
Moderators of the effect of entrepreneurship education on entrepreneurial action
Authors: Ripollés Maria , Blesa Andreu 
Published: March 2023

PurposeThe role of entrepreneurship education in promoting entrepreneurial actions remains unclear. The purpose of this paper is to investigate the logic of different types of entrepreneurship education and the effect of learning characteristics in promoting entrepreneurial actions among student entrepreneurs in the higher education setting.Design/methodology/approachThe study employs a quantitative approach involving the use of survey data collected via an Internet tool. The constructs of variables are measured using previously tested scales. The data were analysed using partial least squares modelling because it can handle formative and reflective constructs in the same model and is capable of testing for moderation.FindingsThe findings illustrate that voluntary entrepreneurship education generates learning outcomes in terms of students' entrepreneurial actions, which is important because without action, a venture will never be launched. This is especially so if students show a deep learning orientation, while mastery motivation showed a significant and negative moderating effect. This is not the case for compulsory entrepreneurship education.Originality/valueEmbedded in construal level theory, this paper offers knowledge that can help to advance entrepreneurship education research (1) by uncovering the role of different types of entrepreneurship education interventions, (2) by considering students' entrepreneurial actions as the dependent variable and (3) by unravelling the role of students' learning characteristics in the efficacy of entrepreneurship education interventions. By doing this, the study addresses recent repeated calls for more fine-grained research focused on how university students learn in entrepreneurship in higher education and its effects.
The role of creativity in principals’ leadership practices towards parental involvement
Authors: Keetanjaly A. , Abdul Kadir Suhaida , Su Luan Wong , Abdullah Arnida 
Published: March 2023

Purpose
The involvement of parents in schools and their contribution towards their children’s academic learning have been a focal point in educational research. The purpose of this paper is to identify the factors that influence parental involvement in secondary schools and subsequently proposed a comprehensive parental involvement model.

Design/methodology/approach
Research articles, reports and dissertations on the factors that influence parental involvement were reviewed to obtain related empirical evidence for the development of a workable model.

Findings
A conceptual framework was proposed to understand the factors that influence parental involvement. The role of creativity in principals’ leadership practices and parental involvement in secondary schools were found to be related. Additionally, this relationship was found to be mediated by school practices and school climate.

Research limitations/implications
A framework on the factors that influence parental involvement guided by literature review and three main hypotheses for testing were proposed, which require further empirical assessment.

Practical implications
The school–parent partnership shares a common understanding of the educational needs and social development of the children. The school administrators, school community, stakeholders and related policymakers can effectively leverage the findings of this study in the effort to enhance parental involvement within the school context.

Originality/value
Only a handful of research-based studies probed into the factors that influence parental involvement in secondary schools within the Malaysian context. This study identified several significant factors that enhance parental involvement in secondary schools.
The influence of spiritual leadership and its impacts on the reduction of workplace deviant behavior
Authors: Mahyarni Mahyarni 
Published: March 2023

Purpose
The purpose of this paper is to examine the influence of spiritual leadership toward spirituality, job satisfaction and reduction of deviant behavior.

Design/methodology/approach
A structural model based on WarpPLS (Solimun et al., 2017) is used for data analysis, with the first-order factor analysis based on variables with reflective indicators.

Findings
The research findings show that the sustainability of workplace spirituality can stimulate employees’ job satisfaction. Accordingly, the direct influence of workplace spirituality on workplace deviant behavior (WDB) is quite major (0.296); this indicates the importance of workplace spirituality for employees in working so it can reduce the WDB. An interesting part about this study is the indirect influence of workplace spirituality on workplace deviant behavior through job satisfaction, which also has a major value (0.208), almost equal to direct influence. This circumstance depicts how workplace spirituality influences workplace deviant behavior, as well as the importance of the improvement of employees’ job satisfaction.

Originality/value
The originality of this study is primarily placed on the causal relationship between the variables of spiritual leadership and WDB, other than the direct influence; there is also an indirect influence that has a big value, which is the path of spiritual leadership toward workplace deviant behavior through workplace spirituality (−0.248). In other words, workplace deviant behavior is not only influenced directly by spiritual leadership but also by workplace spirituality.
Psychopathy screening for public leadership
Authors: Boddy Clive Roland 
Published: March 2023

PurposeThe purpose of this paper is to re-open a debate as to whether candidates for public leadership should be screened for psychopathy.Design/methodology/approachThis is a conceptual paper which examines the diffuse literature concerning psychopaths in public leadership positions.FindingsPsychopathy researchers have been divided as to whether psychopathic individuals should be screened out of leadership positions in public and corporate life. Recent evidence from bullying research and historical research into psychopaths in politics sheds new light on this issue.Practical implicationsThere is increasing evidence that psychopaths are detrimental to the organisations they work for, to other employees, to the environment and to society. Screening for psychopathy should therefore be considered. This may help to prevent governments entering into illegal wars and committing crimes against humanity. Screening in the corporate sector may also help prevent the worst excesses of greed and fraud that were evident in collapses like Enron and the Mirror Group as well as in the events leading up to the global financial crisis of 2008.Originality/valueThe paper makes a contribution to the literature on public leadership by bringing together the diverse reports on the effects of psychopaths in public organisations like the National Health Service, publicly listed corporations, academia and politics. The paper uses historical and corporate examples to illustrate the initially favourable impression that psychopathic leaders can make but the ultimately disastrous outcomes they engender.
Farmer–trader relationships in the context of developing countries: a dyadic analysis to understand variations in trust perceptions
Authors: Owot Godfrey Moses , Olido Kenneth , Okello Daniel Micheal , Odongo Walter 
Published: March 2023

PurposeThe purpose of this study is to analyze trust perceptions between farmers and traders from a dyadic context in developing countries using mixed-method with a specific focus on fresh and dry commodities under contracted and non-contracted markets.Design/methodology/approachA mixed approach was employed. Cross-sectional data were collected from 202 farmers and 188 traders using questionnaires and an interview guide. The Mann–Whitney test was used to assess differences in trust perception. Differences in the excerpts were assessed through content analysis.FindingsResults show differences in perception of trust between farmers and traders on integrity, benevolence and competence in marketing fresh and dry commodities. No detectable differences in trust perception between contract and non-contract markets were observed.Research limitations/implicationsData are limited to Northern Uganda and were collected on trust perception. Besides, there is a scarcity of formal contracts and difficulty in having a matched dyad which could affect generalization.Originality/valueThis is the first study to analyze differences in trust perceptions using a mixed approach in a dyadic context between fresh and dry chains in different markets typologies in developing countries.
Unveiling the indigenous art and craft of bakat and its economic significations
Authors: Inocian Reynaldo Bontuyan , Cuestas Niño James P. , Carin Justin Keith L. , Canoy Jhon Daryl E. 
Published: March 2023

Purpose
The purpose of this paper is to unveil the intricacies of bakat art of weaving; its origin; processes; uses; primary materials and principles used; the profile of the weavers; and its economic significations in the system of production and trade.

Design/methodology/approach
The study used a descriptive–qualitative design with 35 key informants using narrative analysis. The unstructured questions listed in the interview guide were used during the interview. Responses were recorded using an audio–video recorder. Coding sheets were used in the actual transcription of data.

Findings
The results showed dependency on the bakat art of weaving with the available resources found in the environment. Its economic significations showed a sustainable impact on the weavers’ life. The bakat art of weaving represented the values of resiliency to hardships, adaptability to changes, passion to craftsmanship, sense of community and family centeredness. Aspiring craftsmen and artists may enhance continuously their craftsmanship for sustainable development with government support through the creation of the School of Living Traditions.

Research limitations/implications
The study was limited to bakat art of weaving based on the responses of the key informants that were subjected to a point of saturation without sacrificing robustness, brevity, credibility and dependability.

Practical implications
Though the economic side of bakat art of weaving is sustainable within the village, it can create a powerful branding for cultural recognition that would transform the town of Barili into a creative weaving hub in Cebu. This creates the balance of the historical significance of bakat art of weaving and the tourism sector in promoting sustainable development.

Social implications
Bakat art rekindled the spirit of consciousness among the majority of the Cebuano public for preservation and promotion.

Originality/value
The study is original because this has not been published.
A binary integer programming (BIP) model for optimal financial turning points detection
Authors: Yazdani Fatemeh , Khashei Mehdi , Hejazi Seyed Reza 
Published: March 2023

Purpose
This paper aims to detect the most profitable, i.e. optimal turning points (TPs), from the history of time series using a binary integer programming (BIP) model. TPs prediction problem is one of the most popular yet challenging topics in financial planning. Predicting profitable TPs results in earning profit by offering the opportunity to buy at low and selling at high. TPs detected from the history of time series will be used as the prediction model’s input. According to the literature, the predicted TPs’ profitability depends on the detected TPs’ profitability. Therefore, research for improving the profitability of detection methods has been never given up. Nevertheless, to the best of our knowledge, none of the existing methods can detect the optimal TPs.

Design/methodology/approach
The objective function of our model maximizes the profit of adopting all the trading strategies. The decision variables represent whether or not to detect the breakpoints as TPs. The assumptions of the model are as follows. Short-selling is possible. The time value for the money is not considered. Detection of consecutive buying (selling) TPs is not possible.

Findings
Empirical results with 20 data sets from Shanghai Stock Exchange indicate that the model detects the optimal TPs.

Originality/value
The proposed model, in contrast to the other methods, can detect the optimal TPs. Additionally, the proposed model, in contrast to the other methods, requires transaction cost as its only input parameter. This advantage reduces the process’ calculations.
Linking the intrinsic and environmental constraints with PwD tourists' behavioral intentions toward a travel destination: mediating role of learned helplessness
Authors: Sarmah Bijoylaxmi , Kamboj Shampy , Chatterjee Ravi 
Published: March 2023

PurposeThe present study examines the antecedents of learned helplessness, i.e. intrinsic and environmental constraints and consequences, i.e. intention to travel and expectation in the context of people with disability (PwD) tourism context by applying the “Theory of Learned Helplessness”.Design/methodology/approachThe survey method was used to gather data from 209 physically disabled people who had visited/traveled to any tourist destination in the past twelve months. Structural equation modeling technique was used to analyze data.FindingsThe findings reveal that intrinsic and environmental constraints positively influence learned helplessness. Consequently, learned helplessness negatively effects intention to travel and positively affects expectation of PWD tourist' toward a travel destination. Furthermore, learned helplessness contributed as a mediator between intrinsic constraints and intention to travel toward a tourist destination.Originality/valueEven though the body of literature on associations studied pertaining the conceptual lens of learned helplessness is widely recognized, there is dearth of literature investigating the connections between travel constraints, learned helplessness, PwDs intention and their expectation in travel destination context.
Turkish nurses' leadership orientations and clinical decision-making skills
Authors: Gürsoy Elif , Yeşildere Sağlam Havva , Başaran Fatma , Çetin Atay Emine , Şimal Yavuz Nurgül 
Published: March 2023

PurposeThe purpose of this study was to determine the relationship between the leadership orientations of nurses and their clinical decision-making skills.Design/methodology/approachThis descriptive study was conducted between June and December 2018 on nurses working at three hospitals in Turkey. This study was completed with 1,100 nurses. The Personal Information Form, Leadership Orientation Scale and Clinical Decision-Making Scale in Nursing were used for data collection.FindingsA significant correlation was found between the leadership orientations of nurses and age, sex, institution where they were employed, time spent in the profession, being in a management position and satisfaction with the current unit of employment (p< 0.05), and a significant correlation was found between clinical decision-making skills of nurses and age, sex and occupational status (p< 0.05). Furthermore, a significant correlation was found between the mean scores of the Leadership Orientation Scale and Clinical Decision-Making in Nursing Scale (p< 0.05).Originality/valueThe development of leadership orientations of nurses positively affects their clinical decision-making skills. In this respect, it is important to instill effective leadership orientations in nurses and to incorporate novel training methods in nursing education to develop accurate and timely clinical decision-making skills.
Police stressors and health: a state-of-the-art review
Authors: Violanti John M. , Charles Luenda E. , McCanlies Erin , Hartley Tara A. , Baughman Penelope , Andrew Michael E. , Fekedulegn Desta , Ma Claudia C. , Mnatsakanova Anna , Burchfiel Cecil M. 
Published: March 2023

Purpose
The purpose of this paper is to provide a state-of-the-art review on the topic of police stressors and associated health outcomes. Recent empirical research is reviewed in the areas of workplace stress, shift work, traumatic stress, and health. The authors provide a comprehensive table outlining occupational exposures and related health effects in police officers.

Design/methodology/approach
A review of recent empirical research on police stress and untoward psychological and physiological health outcomes in police officers.

Findings
The results offer a conceptual idea of the empirical associations between stressful workplace exposures and their impact on the mental and physical well-being of officers.

Research limitations/implications
A key limitation observed in prior research is the cross-sectional study design; however, this serves as a motivator for researchers to explore these associations utilizing a longitudinal study design that will help determine causality.

Originality/value
This review provides empirical evidence of both mental and physical outcomes associated with police stress and the processes involved in both. Research findings presented in this paper are based on sound psychological and medical evidence among police officers