bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effects of regular exercise on cognitive and cardiometabolic health in testicular cancer survivors subjected to platinum‐based chemotherapy
Authors: Amiri Ali , Slobodová Lucia , Klepochová Radka , Schön Martin , Marček Malenovská Karin , Rerková Katarína , Pechancová Radka , Prievalský Martin , Litváková Viera , Oliva Viktor , Pluháček Tomáš , Sedliak Milan , Mego Michal , Krššák Martin , Chovanec Michal , Ukropcová Barbara , Ukropec Jozef 
Published: January 2025

AbstractBackgroundPlatinum‐based chemotherapy provides curative treatment to more than 95% of patients with testicular germ cell tumor but it has negative cardiometabolic and neurological effects. Regular exercise can alleviate late chemotherapy‐related toxicities. We examined the impact of a 6‐month supervised aerobic‐strength training on cognitive and cardiometabolic health and residual level of platinum in cancer survivors.MethodsTwenty‐eight middle‐aged (42.1 ± 7.6 years) testicular germ cell tumor survivors subjected to platinum‐based chemotherapy (1–8 cycles, 0–24 years ago) were recruited into exercise (n = 20) and control (n = 8) groups. Effects of 6‐month exercise training on the whole‐body and muscle metabolism, cognitive functions, cardiopulmonary fitness, residual plasma platinum, and plasma adiponectin were examined.ResultsExercise intervention improved cardiopulmonary fitness and cognitive functions, reduced residual plasma platinum, visceral adiposity and muscle lipids, improved glucose (glycosylated hemoglobin) and lipid (high‐density lipoprotein cholesterol) metabolism, and enhanced dynamics of muscle post‐exercise phosphocreatine recovery. Exercise‐related decline in plasma platinum was paralleled by decline of muscle glycerophosphocholines and by the enhanced metabolic flexibility during low‐intensity exercise, and predicted training‐induced increase in cognitive functions.ConclusionsThe 6‐month exercise intervention resulted in improved cognitive and cardiometabolic health in testicular germ cell tumor survivors, which was paralleled by reduced plasma platinum, providing evidence that structured supervised exercise brings multiple health benefits to testicular germ cell tumor survivors.
Blood Group B May Reduce Risk of Rebleeding in Patients With Upper Gastrointestinal Haemorrhage due to Peptic Ulcer Disease
Authors: Taylor Sarah , Chen Lynna , Dutt Krishneel , Boyapati Ray , Ye Bei , Ong Sim , Kruavit Anuk , Lee Nora , Apostolov Ross , Suleiman Mani , Tacey Mark , Ho Prahlad , Gibson Peter R. , Garg Mayur 
Published: January 2025

ABSTRACTRisk stratification tools for the prediction of complications in patients with upper gastrointestinal haemorrhage are crucial for appropriate management. Blood group status has been associated with the risk of bleeding, thrombosis and risk of peptic ulcer disease (PUD). We assessed the influence of blood group status on rebleeding and other complications in 699 patients with PUD bleeding. Blood group B was associated with reduced risk in the composite outcome of rebleeding, need for surgery or embolisation and mortality (OR 0.15, 95% CI 0.04–0.63, p = 0.009). Blood group B was protective against rebleeding compared to non‐blood group B (OR 0.20, 95% CI 0.05–0.84, p = 0.028).
Social network analysis in social psychological ressearch (1990–2020): A scoping review
Authors: Mehrpour Anahita , Widmer Eric D. , Staerklé Christian 
Published: January 2025

AbstractOver the last two decades, Social Network Analysis (SNA) has become a standard tool in various social science disciplines. In social psychology, however, the use of SNA methodology remains scarce. This research identifies gaps in SNA use in Social Psychology and offers pathways for its further development. It reviews all empirical papers using SNA published in high‐ranking social psychology journals over the last three decades. Findings reveal that SNA has been used across striking diversity of fields and subdomains central to the discipline, confirming its relevance for any field in Social Psychology in which the role of interpersonal or intergroup relationships is central to understand psychological and behavioural outcomes. However, the use of SNA in Social Psychology has been mostly limited to non‐experimental and non‐longitudinal studies, using student samples and with a focus on basic measurements of network structures such as density and centrality. The contributions of SNA to the understanding of psychosocial mechanisms have therefore remained modest. We propose several strategies by which such gaps can be filled in future research and the full potential of SNA for social psychology realized.
AURKA/PLK1/CDC25C Axis as a Novel Therapeutic Target in INI1‐Deficient Epithelioid Sarcoma
Authors: Inoue Akitomo , Outani Hidetatsu , Imura Yoshinori , Nakai Sho , Takami Haruna , Kotani Yuki , Mae Hirokazu , Okada Seiji 
Published: January 2025

ABSTRACTEffective therapeutic strategies for epithelioid sarcoma (EpS), a high‐grade soft tissue sarcoma characterized by loss of integrase interactor 1 (INI1), have not yet been developed. The present study therefore investigated the association between INI1 loss and upregulation of the aurora kinase A (AURKA)/polo‐like kinase 1 (PLK1)/cell division cycle 25C (CDC25C) axis, as well as the therapeutic relevance of this axis in EpS. Notably, our findings showed that the reintroduction of INI1 in VA‐ES‐BJ cells significantly reduced proliferation, mitigated tumorigenicity, and negatively regulated the expression of AURKA and its downstream effectors, as well as the activation of PLK1 and CDC25C. These results suggest that INI1 deficiency enhanced EpS growth by upregulating the AURKA/PLK1/CDC25C axis. AURKA silencing using siRNAs inhibited VA‐ES‐BJ and Asra‐EPS cell proliferation by inactivating PLK1 and CDC25C. Alisertib, a selective AURKA inhibitor, exerted markedly greater antiproliferative effects on EpS cells than on normal human dermal fibroblasts, and these effects were dependent on INI1 deficiency. Inhibition of AURKA activity by alisertib induced G2/M cell cycle arrest and apoptosis via the inactivation of AURKA downstream effectors in EpS cells. Alisertib also significantly decreased VA‐ES‐BJ xenograft tumor growth. Taken together, our findings revealed that INI1 loss in EpS cells enhances the expression of AURKA and its downstream effectors and persistently activates PLK1 and CDC25C mediated by AURKA, making the cells reliant on the AURKA/PLK1/CDC25C axis. Therefore, the AURKA/PLK1/CDC25C axis activated by INI1 deficiency could serve as a novel therapeutic target for this devastating disease.
Does Weekend Discharge Affect Readmission and Survival in Liver Transplant Patients? Insights From a Cohort Study
Authors: Obana Ayato , Akabane Miho , Chi Hannah , Ladd Nolan , Yoder Matthew , Kaufman Lily , Punjala Rithin , Shah Kejal , Hamilton Matthew , Limkemann Ashley , Schenk Austin , Singh Navdeep , Slyvester Black , Mumtaz Khalid , Washburn Kenneth , Alebrahim Musab 
Published: January 2025

ABSTRACTBackgroundWeekend hospital discharges are often associated with reduced staffing, potentially impacting the quality of patient care. We studied the effects of weekend discharge after liver transplantation (LT) on early readmission rates, overall survival (OS), and graft survival (GS).MethodWe analyzed data from the Ohio State University Wexner Medical Center database (January 2016 to December 2023). The study included initial LT recipients (LTRs) including donation after brain death (DBD) and donation after cardiac death (DCD). Primary outcomes encompassed early readmission rates, and secondary outcomes included OS and GS.ResultsThe cohort comprised 915 LTRs (645 DBD, 270 DCD), with 156 (17.0%) weekend and 759 (83.0%) weekday discharges. Regarding discharge disposition, 681 (74.4%) patients were discharged home, 210 (22.9%) were discharged to healthcare facilities. No significant differences were identified in the length of hospital stay (8 days vs. 9 days, weekend vs. weekday, respectively, p = 0.22) or 30‐day readmission (29.5% vs. 32.5%, weekend vs. weekday, respectively, p = 0.75). There were no significant differences in OS (90.9% vs. 92.7% at 1‐year, 84.4% vs. 88.0% at 3‐year, weekend vs. weekday, p = 0.27) and GS (90.9% vs. 91.5% at 1‐year, 84.0% vs. 86.6% at 3‐year, weekend vs. weekday, p = 0.50). Multivariate logistic analysis showed no significant impact of weekend discharge (OR: 0.84 [0.57–1.22], p = 0.35) or discharge disposition (OR: 1.00 [0.75–1.33], p = 1.00) on 30‐day readmission. Multivariate Cox regression analysis found no significant impact of weekend discharge or discharge disposition on OS and GS (all p > 0.05).ConclusionWeekend discharge does not impact early readmission, OS, or GS in LTRs. These findings are a testament to our multidisciplinary team efforts and suggest that with appropriate discharge planning and follow‐up care, the timing of discharge may be less critical than previously assumed.
Adverse events of 20–22G second‐generation endoscopic ultrasound‐guided fine‐needle biopsy needles for solid lesions in the upper gastrointestinal tract and adjacent organs: Systematic review and meta‐analysis
Authors: Pan Cheng‐ye , Wang Shi‐min , Cai Dong‐hao , Ma Jia‐yi , Li Shi‐yu , Guo Yibin , Jing Sun , Zhendong Jin , Wang Kaixuan 
Published: January 2025

ObjectivesPrevious research has conducted meta‐analyses on the diagnostic accuracy of endoscopic ultrasound‐guided fine‐needle biopsy (EUS‐FNB). However, studies on adverse events (AEs) have been limited and sporadic and have included a highly diverse group of patients (with upper and lower gastrointestinal tract issues) and needles of varying sizes (19‐22‐25G). The purpose of this systematic review and meta‐analysis was to determine the incidence of AEs related to the utilization of 20–22G second‐generation EUS‐FNB needles subsequent to puncture of the upper gastrointestinal tract and adjacent organs.MethodsWe searched the PubMed, Embase, and SCIE databases from January 1, 2010, to December 31, 2023. The primary outcome was percentage of summary AEs. Subgroup analyses were based on needle type, needle size, and lesion site.ResultsA total of 99 studies were included in the analysis, with 9303 patients. The overall AE rate for 20–22G second generation EUS‐FNB needles in upper gastrointestinal EUS‐FNB was 1.8% (166/9303), with bleeding being the most common AE at 44.0%. The percentages of pancreatitis, abdominal pain, and other AEs were 24.1%, 21.1%, and 10.8%, respectively. Patients undergoing hepatic EUS‐FNB had the highest incidence of AEs at 14.0%, followed by submucosal lesions at 3.2% and pancreatic lesions at 2.6%.ConclusionEUS‐FNB is a safe procedure with a relatively low risk of upper gastrointestinal AEs (1.8%) and no associated deaths. Postoperative bleeding and pancreatitis are the most common complications of EUS‐FNB. Most AEs are mild and self‐limiting in severity, and serious complications are very rare.
Big Moves, Small Gains: Unpacking the Size Effect in Takeovers and Other Corporate Deals
Authors: Roma Antonio , Consolandi Costanza 
Published: January 2025

ABSTRACTThis study explores the size effect in financial markets, focusing on how mergers, acquisitions, and other corporate transactions influence the returns of small versus large stocks. Employing a comprehensive data set of US‐listed companies from 1992 to 2021, which includes 51,780 events, this research improves upon previous methodologies by integrating detailed timing information on deal announcements and completions with stock size and return data. Our analysis shows that small stocks are often the targets of transactions that significantly enhance their returns, not limited to takeovers. We find that pre‐announcement returns are consistently higher for small stocks, likely due to less analyst coverage, resulting in largely unanticipated deal news. The study deepens our understanding of the size effect, suggesting that deal‐related dynamics are essential for analyzing performance variations across different stock sizes and contributing to discussions on market efficiency and the valuation effects of corporate actions.
Soil Pore System Functionality in a Micro‐Watershed Formed by Wet Meadows (Vegas) in the Southernmost Chilean Patagonia
Authors: Ivelic‐Sáez J. , Cisternas P. , Clunes J. , Dörner J. , Arumí J. L. , Valle S. , Valenzuela J. , Muñoz E. , Dec D. , Horn R. 
Published: January 2025

ABSTRACTWetlands occupy a small percentage of the Earth's surface but provide essential ecosystem services, such as water regulation, carbon cycling and habitat support. Patagonian “Vegas” are unique wetland ecosystems characterised by their groundwater recharge and hydrological dynamics, distinct from the surrounding steppe. These ecosystems play a critical role in supporting livestock with up to six times the forage productivity of the surrounding steppe and in storing over 69 g kg−1 of organic carbon. However, the influence of soil structure parameters (e.g., pore size distribution, bulk density) and soil shrinkage behaviour on soil moisture variability and ecosystem functions in Patagonian wetlands remains poorly understood. This study aimed to assess the physical capacity and intensity parameters of soils, including shrinkage properties, within a micro‐watershed in southern Patagonia. Our findings reveal significant spatial variability in soil properties, with bulk density (BD) ranging from 0.12 to 1.81 Mg m−3 across topographic positions. Mineral soils on summits and footslopes exhibited high macroporosity (up to 18.1% of total pore volume at 5 cm depth), which facilitates water movement, while organic soils in the Vega centre had a higher total porosity (up to 88.8%) that enhances water and air retention. The coefficient of linear extensibility (COLE) for organic soils reached a level of 0.078, indicating a high shrinkage capacity. This shrinkage influenced the functionality of the porous system, shifting pore roles between air conduction and water storage as larger pores contracted. These dynamics, driven by climate change and increased drying cycles, may lead to significant shifts in soil functionality and ecosystem resilience. Enhanced understanding of soil physical states and their response to environmental changes can support sustainable management strategies, benefiting local agriculture and preserving these critical ecosystems.
Factors influencing equine veterinarians' job satisfaction and retention: A focus group study
Authors: Whitaker Kristen , Burnette Audrey , Tan Jean‐Yin , Graves Meggan , Hunt Julie , Devine Elizabeth , Anderson Stacy , Kirkendall Katherine , Wisnieski Lauren 
Published: January 2025

AbstractBackgroundThere is a shortage of equine veterinarians. Understanding what factors are associated with job satisfaction in equine veterinarians can inform interventions to increase retention in equine medicine.ObjectiveTo explore the prominent factors causing work dissatisfaction and burnout in equine veterinarians.Study designQualitative research study consisting of semi‐structured focus groups.MethodsThirty‐seven current and former equine veterinarians across the United States were recruited via snowball and convenience sampling to answer questions on work history, work–life balance, and perceptions of equine practice. Transcripts were analysed in Delve and coded in the context of the Conservation of Resources (COR) theory. A card sorting activity was used to rank the four types of resources in the COR theory (condition, object, energy, and personal).ResultsCondition resources were the most frequently mentioned reasons for work dissatisfaction. These included issues with discrimination or bias due to age, race/ethnicity, and gender, unpredictable and long hours, and heavy workloads. Object resources, such as equipment, were rarely mentioned. Energy resources, including pay and student loan debt, were influential, with most participants feeling that equine veterinarians are underpaid. Personal resources, such as problem‐solving skills and enjoyment in helping others, improved job satisfaction.Main limitationsAlthough recruiting efforts prioritised perspectives of black, indigenous, and people of colour, lesbian, gay, bisexual, transgender, queer plus identities, and members with disabilities, demographic information was not directly collected.ConclusionsThe main barriers to equine veterinary retention included a lack of work–life balance, long hours, lower‐than‐expected pay, and issues with discrimination and bias. This study highlights areas for intervention to improve the equine veterinary field, such as higher pay, rural practice incentives, and effective diversity, equity, inclusion, and belonging (DEIB) efforts. A shift toward caseload‐sharing between veterinarians could help alleviate excessive emergency on‐call and burnout.
Emerging Ideas. How important is formal child support for family economic well‐being?
Authors: Cancian Maria , Costanzo Molly A. , Meyer Daniel R. 
Published: January 2025

AbstractObjectiveThis study investigates the role of child support in family economic well‐being and how it has shifted over recent decades, considering differences by family characteristics.BackgroundThe formal child support program has wide reach and has historically been an important source of income for some. Recent critiques indicate the potential for negative impacts on families and decreasing efficacy.MethodsUsing data from the 1998, 2008, and 2018 Current Population Survey and the linked Child Support Supplement, this study compares proportions of total family income drawn from child support and other sources. Nonpoor and poor custodial families are considered as well as other relevant subgroups.ResultsFor poor families, child support increased from 11% to 15% of family income in 1997–2007 then declined to 12% in 2017. For nonpoor families, it declined over the period, from 3.9% to 3.4% to 2.6%. For poor families with orders, almost 23% of income comes from child support; for those receiving payments, the proportion is 33%.ConclusionAcross most subgroups, child support is no longer increasing in importance and, for some groups, is a declining share of income. Nonetheless, it remains an important source of income for many low‐income families.Implications for Emerging IdeasThis study provides updated evidence about the changing importance of formal child support for families. Understanding the importance of formal support is important in weighing the benefits of income received relative to potential costs of enforcing payments on low‐income parents and any disruptions to their relationships with their children it may cause.
Consideration of culture in Canadian courtrooms: Before and after the Divorce Act amendments
Authors: Singh Terry , Bannister Traci , Massie Marc 
Published: January 2025

AbstractIn Canada, the federal Divorce Act was revised in 2021 to include enumerated best interests factors which include a child's linguistic, religious, cultural, and spiritual heritage and upbringing, including Indigenous heritage. In this study, the authors examine how Canadian courtrooms engaged in the consideration of cultural factors prior to the recent Divorce Act amendments and compare these findings to decisions published following the amendments that mandated this specific consideration. Specific manners in which the courts have considered culture are identified, and the resulting three ‘clusters’ of decisions—including those cases (a) prioritizing a child's established culture, (b) weighing the child's greater involvement with one culture versus increased bicultural competence, and (c) considering the effect on the child of the cultural interaction—are compared pre‐ and post‐ the recent Divorce Act amendments. Implications for family court professionals are discussed.
Fatigue Behavior and Inclusion‐Based Lifetime Prediction of 42CrMo4 Steel
Authors: Kirste Thomas , Schmiedel Alexander , Morgenstern Roman , Weidner Anja , Biermann Horst 
Published: January 2025

ABSTRACTThree variants of 42CrMo4 steel were investigated regarding the fatigue life at two test frequencies of 90 Hz and 20 kHz and temperatures up to 500°C. The materials varied in different levels of sulfur and oxygen content and steel cleanliness in terms of nonmetallic inclusions. The steels had a tempered martensitic microstructure with a hardness of 300 HV. A frequency dependence was observed only for the medium‐sulfur steel, whereas for low‐ and high‐sulfur levels, both test frequencies yielded in a common S‐N curve. The fracture surface analysis of the fatigue specimens was compared with the inclusion rating done on unloaded samples. A correlation of both methods was observed by introducing a size factor. Based on the distribution functions and by using Murakami's approach of a projected area of an inclusion, a method was developed to predict the S‐N curve. This offers the opportunity for an inclusion‐based lifetime prediction.
Workload and emotional exhaustion among older assistant care workers in Japan: Buffering effect of work resources
Authors: Ma Panpan , Sagara Tomoya , Takase Mai , Sugiura Keiko , Nakamoto Isuzu , Muto Yoko , Higashi Kentaro , Fujiwara Yoshinori , Murayama Hiroshi 
Published: January 2025

AimBased on the Job Demands–Resources model, this study aimed to assess the predictive effect of workload on emotional exhaustion and test the buffering effect of three types of work resources (workplace cohesion, work control, and workplace support) on the relationship between workload and emotional exhaustion among older Japanese assistant care workers.MethodsWe analyzed data from a national survey on the work features and work‐related outcomes of 1601 older assistant care workers working in geriatric health services facilities in Japan. Demographic characteristics, workload, work resources, and emotional exhaustion were analyzed. A hierarchical multiple regression analysis and simple slope test were conducted.ResultsWorkload had a significant main effect in predicting emotional exhaustion (β = 0.337, P < 0.001). Workplace cohesion buffered the negative effect of workload on emotional exhaustion (interaction between workload and workplace cohesion: β = −0.097, P = 0.002). Work control (interaction between workload and work control: β = −0.015, P = 0.585) and workplace support (interaction between workload and workplace support: β = 0.025, P = 0.391) had no buffering effect on the negative impact of workload on emotional exhaustion.ConclusionsRegulating workload and promoting workplace cohesion might be effective strategies for preventing burnout among elderly workers. Investigations into the occupational stress of elderly workers from diverse cultures and work contexts are needed. Geriatr Gerontol Int 2025; 25: 273–278.