bluuebunny/crossref_metadata_2025_split huggingface dataset:
Entre nature et culture
Authors: Antonioli Manola 
Published: March 2023

À partir des Essais sur la nature et la culture de Vilém Flusser, l’article se propose d’étudier les liens complexes entre nature et culture que l’auteur met en œuvre dans sa pensée. Dans ses Essais, Flusser étudie les chemins comme une hybridation entre le projet conscient de la culture humaine, le « projet » tracé par des animaux et la dimension (prétendument « naturelle ») des paysages. On y trouve également des réflexions sur les animaux (vaches et oiseaux) et sur la scène de l’écriture qui associe la dimension « naturelle » des doigts aux machines d’écriture (du stylo à la machine à écrire et ensuite à l’ordinateur). Dans Les gestes, le geste de planter devient le point de départ d’une réflexion sur l’agriculture et l’écologie, qui se poursuit dans le texte inédit intitulé « Considérations “écologiques” ». Pour conclure, nous évoquerons les nouvelles relations qui se tissent entre monde humain et mondes animaux dans l’ouvrage consacré au Vampyroteuthis infernalis, fruit de la longue collaboration entre Vilém Flusser et l’artiste Louis Bec.
Décomposition de la forme « projet »
Authors: Beaubois Vincent 
Published: March 2023

La notion de « projet » se présente aujourd’hui comme le régime spécifique de l’activité de création et comme la forme temporelle de la production de l’innovation. Vilém Flusser, dans sa pensée du design des « choses » (mécaniques) comme des « non-choses » (digitales), propose une lecture originale de l’histoire et de l’épistémologie des pratiques de conception. Cette lecture passe justement par cette notion de « projet » qui agit comme un attracteur emportant dans une même dynamique deux perspectives distinctes : celle du « projet existentiel » pensé comme réalisation et transformation individuelles et sociales, et celle du « projet technologique » pensé comme processus d’innovation. L’articulation de sa philosophie du design et de sa réflexion sur la post-histoire autour de cette notion de « projet » engage ainsi une critique de la pensée « moderne » du développement technique : le design n’agit plus comme un processus de « résolution de problèmes » censé améliorer nos conditions de vie, mais comme la programmation de « mondes alternatifs » dans lesquels se moulent nos actions. De cette évolution de la compréhension du design découle une décomposition de la forme temporelle qu’incarne la notion de « projet ».
On the stability of ring relative equilibria in the N-body problem on with Hodge potential
Authors: Andrade Jaime , Boatto Stefanella , Crespo F. , Espejo D.E. 
Published: March 2023

AbstractIn this paper, we study the stability of the ring solution of the N-body problem in the entire sphere
$\mathbb {S}^2$
by using the logarithmic potential proposed in Boatto et al. (2016, Proceedings of the Royal Society of London. Series A. Mathematical, Physical and Engineering Sciences 472, 20160020) and Dritschel (2019, Philosophical Transactions of the Royal Society of London. Series A. Mathematical, Physical and Engineering Sciences 377, 20180349), derived through a definition of central force and Hodge decomposition theorem for 1-forms in manifolds. First, we characterize the ring solution and study its spectral stability, obtaining regions (spherical caps) where the ring solution is spectrally stable for
$2\leq N\leq 6$
, while, for
$N\geq 7$
, the ring is spectrally unstable. The nonlinear stability is studied by reducing the system to the homographic regular polygonal solutions, obtaining a 2-d.o.f. Hamiltonian system, and therefore some classic results on stability for 2-d.o.f. Hamiltonian systems are applied to prove that the ring solution is unstable at any parallel where it is placed. Additionally, this system can be reduced to 1-d.o.f. by using the angular momentum integral, which enables us to describe the phase portraits and use them to find periodic ring solutions to the full system. Some of those solutions are numerically approximated.
Knowledge, attitude, and perception of low back pain and activities that may prevent it among adolescents in Nigeria
Authors: Bello Bashir , Aminu Abdulbaki , Abdullahi Auwal , O Akindele Mukadas , Useh Ushotanefe , A Ibrahim Aminu 
Published: March 2023

Background: Awareness of activities that may result in low back pain (LBP) among adolescents is fundamental in preventing adulthood LBP.
Objective: The aim of this study was to investigate adolescents' knowledge, attitude, and perception of LBP and activities that may prevent LBP in Kano, North-western, Nigeria.Methods: This was a cross-sectional survey involving 400 school-going adolescents recruited using a multistage random sampling technique. Data was analysed using descriptive statistics and Chi-square test with 0.05 set as level of significance.
Results: The mean age of the respondents was 16.0±1.50 years. LBP annual prevalence was 34.2%, with more girls (31.1%) reporting having LBP compared to boys (28.4%). More than half (59.3%) of the respondents had poor knowledge of LBP and activities that may prevent it. However, they had a good attitude (63%) and perception (74%) of LBP and activities that may prevent it. There was no significant association of levels of knowledge, attitude, and perception of LBP and activities that may prevent LBP with gender, age, and class of study (p > 0.05).
Conclusion: Adolescents in Kano, North-western Nigeria had poor knowledge of LBP and activities that may prevent it. Therefore, there is a need to embark on an LBP prevention program among adolescents in Kano, North-western Nigeria.
Keywords: Low back pain; prevention; adolescents; knowledge; attitude; perception.
A meta-analysis and experimental data for multidrug resistance genes in breast cancer
Authors: Zaib Shumaila , Tahir Sammia , Masood Nosheen , Hameed Abdul , Yasmin Azra 
Published: March 2023

Background: Increasing trend of breast cancer incidence worldwide is a known fact. This curable disease may become fatal if drug resistance is developed leading to metastatic cancerous tissue.
Objective: This is a two parts study; a meta-analysis exploring association of drug resistance (mdr1 and ABCG2) genes with breast cancer and mutational association with molecular subtypes of cancer.
Methods: PCR-SSCP for genomic polymorphisms and RT-PCR for expression analysis were performed.
Results: C3435T polymorphism of mdr1 gene was most commonly studied mutation with contradictory results. Association of ABCG2 gene mutations with untreated breast cancer was reported only by one study so far. Regarding current genomic analysis of mdr1 gene, three novel mutations were found in exon 12 and 2 mutations were found in exon 26. In ABCG2 gene, addition of C and T were found in intron 8 at the intron-exon junction. A positive correlation was observed between these mutations and tumor grade. Levels of mRNA expression revealed that they were over expressed in cancerous tissues compared with controls.
Conclusion: These findings suggest that these genes are associated with breast cancer.
Keywords: Expression; mutations; mdr1; ABCG2; breast cancer.
Childhood colostomies: patterns, indications and outcomes in a Nigerian University Teaching Hospital
Authors: Obiora Ezomike Uchechukwu , Esther Nwachukwu Ijeoma , Ifeanyi Nwangwu Emmanuel , Sunday Chukwu Isaac , Chukwuemeka Aliozor Samson , Perpetua Nwankwo Elochukwu , Okwuchukwu Ekenze Sebastian 
Published: March 2023

Background: Most childhood colostomies are done for decompression or diversion in gastrointestinal tract congenital anomalies.Colostomy may be sited in the transverse or sigmoid colon as loop or defunctioning (divided) colostomies. Current pattern seems towards construction of more sigmoid and defunctioning colostomies.
Aims: To evaluate the patterns, indications and outcomes of childhood colostomies.
Patients and Methods: Retrospective chart review of all colostomies performed in children below 15 years from September 2010 to August 2020.
Results: There were 104 colostomies (55males; 49females; 65 sigmoid; 39 transverse colostomies; 3 loop; 101 defunctioning colostomies. Anorecatal Malformation (ARM)was indication in 32 males and 41 females; age range 2 days to 13 years. Hirschsprung’s Disease (HD) was indication in 18 males and 4 females; age range 6 weeks to 15 years.In HD there were three loop colostomies (3/22) in transverse colon and 19 defunctioning colostomies (8 sigmoid, 11 transverse) while in ARM all 73 were defunctioning colostomies(P=0.01) In HD there were 14/22 transverse colostomies and 8/22 sigmoid colostomies while ARM had 24/73 transverse and 49/73sigmoid colostomies (P =0.013) In HD 91% colostomies were done beyond infancy while in ARM 93% were before one year(P<0.0001). Mortalities were notedin 1.9% patients.
Conclusion: Commonest indication for colostomy is ARM. There are more defunctioning than loop colostomies, and more sigmoid than transverse colostomies. of most colostomies in ARM were during infancy while mostly beyond infancy in HD.
Keywords: Childhood colostomies; oatterns; indications; outcomes.
The effect of obesity on metabolic parameters: a cross sectional study in adult women
Authors: Ramazan Karadogan Seyit , Canbolat Eren , Pınar Cakıroglu Funda 
Published: March 2023

Background: In this study conducted in adult healthy women, it was aimed to determine the relationship between anthropometric measurements such as Body Mass Index (BMI), waist circumference, waist/height ratio and blood parameters, which are used to define obesity.
Methods: A total of 90 women, with a mean age of 38.4±8.8 years, 34 pre-obese between BMI: 25.0-29.9 kg/m2 and 56 obese BMI: ≥30.0 kg/m2, participated in the study.
Results: According to plasma atherogenic index (PAI), women with high cardiovascular risk had lower high-density lipoprotein (HDL) values, while low-density lipoprotein (LDL), triglyceride (TG), aspartate transaminase (AST) values were found to be higher (p<0.05). It was observed that obese women according to BMI had higher fasting glucose, TG, alanine transaminase (ALT), AST and urea values, and lower HDL and mean erythrocyte volume (MCV) values compared to pre-obese women (p<0.05). A moderately positive relationship was found between body fat percentage, waist circumference and waist/height ratio and fasting glucose and ALT levels of women, and a moderate negative relationship was found between vitamin D levels (p<0.05).
Conclusions: It is understood that the increase in body fat tissue, especially in the abdominal region, in adult healthy women has negative effects on blood parameters and the risk of developing chronic diseases will decrease by preventing this situation.
Keywords: Obesity; Abdominal Fat; Blood Chemical Analysis; Women's Health; Anthropometry.
Breast biomarkers profile of invasive lobular carcinoma in a cohort of arab women shows no significant differences from carcinoma of no special type
Authors: Al Nemer Areej 
Published: March 2023

Objectives: Invasive lobular carcinoma (ILC) of the breast is known for its common presentation at an older age, and the frequent expression of favourable profile of estrogen and progesterone receptors (ER & PR) positivity, and human epidermal growth factor receptor 2 (HER2) negativity combined with low proliferation rate as measured by Ki67. This study aimed to test these clinicopathological features of ILC in an Arabic cohort.
Methods: All breast biopsies diagnosed as IDC or ILC were retrospectively reviewed over 2 years period (2017-2018) in an academic centre. Variables were compared using Fisher’s exact test for statistical significance.
Results: A total of 134 cases were recruited, 12.7% were ILC. The median age was 52 years for both types. Clustering of ILC cases was noticed in luminal A subtype (47.1%), but there was no statistically significant difference in subtyping between the 2 histologic groups. Ki67 was significantly lower in ILC than IDC category.
Conclusions: Our study showed that ILC in our cohort lacks the advantage of older age and the common high expression of ER positivity in comparison to IDC. There is, however, significant difference of the value of Ki67 proliferation marker. The prognosis of lobular morphology is questionable in our cohort.
Keywords: Biomarkers; breast carcinoma types; immunohistochemistry; invasive lobular carcinoma; Ki67.
Factors associated with adverse obstetric events following induction of labour: a retrospective study in a tertiary hospital in Ghana
Authors: Adu-Bonsaffoh Kwame , Seffah Joseph 
Published: March 2023

Background: Induction of labour (IOL) remains an indispensable intervention in obstetric practice; however, it may be associated with significant untoward perinatal outcomes. This study determined the major adverse outcomes of IOL and the associated factors at a tertiary hospital in Ghana
Methods: Retrospective study involving women with singleton gestations, conducted at the Korle Teaching Hospital in Ghana. Multivariable logistic regression was used to explore the factors associated with adverse outcomes of IOL.
Findings: A total of 195 women who had IOL were analysed with 161 (82.6%) and 34 (17.4%) undergoing vaginal and caesarean deliveries respectively. The main IOL methods used included Misoprostol (91.3%), Oxytocin (5.1%) and Foley’s catheter (3.6%). Composite adverse perinatal outcomes occurred in 46 neonates (23.6%) comprising perinatal deaths (7.2%) and or NICU admission (21.0%). Caesarean delivery following IOL was significantly associated with nulliparity, gestational age <41 weeks, hypertensive disorders in pregnancy and birth weight ≥3.5kg. Gestational age <41 weeks and birth weight <2.5kg weresignificantly associated with adverse perinatal outcome. Five women (2.6%) had uterine rupture all of which occurred in the misoprostol group.
Conclusion: Induction of labour may result in significant perinatal complications which are related to both maternal (nulliparity and hypertension) and fetal (gestational age and birth weight) factors. Strict selection criteria and continuous fetal-maternal monitoring are strongly recommended to improve the birth outcomes of IOL.
Keywords: Induction of labour; adverse outcomes; Ghana.
Association between dietary patterns and pregnancy induced hypertension: a case control study from Sudan
Authors: Nahla Kambal , A Ibrahim Bani , A Rahim Bahaa-eldin E 
Published: March 2023

Background: Dietary patterns and its associated factors and can play an essential role in development of preeclampsia and implication in pregnancy-induced hypertension (PIH).
Objective: This study was performed to determine nutritional factors associated with PIH among pregnant women in Khartoum, Sudan.
Methods: This study was a case-control involving 100 women with PIH and 200 normotensive pregnant women.
Results: The mean current weight in the control and PIH groups was 70.25 ± 12.35 and 72.42 ± 12.33 kg; whereas the mean energy intake in the control and PIH groups was 1991.58 ±140.72 and 2154.37 ± 130.85 kcal, respectively. The study results indicated a significantly lower risk of PIH among women ingesting fruits and legumes (odds ratio, 8.44 and 4.07, respectively; 95% confidence interval; P < 0.05).
Conclusion: PIH was positively associated with higher energy, fat, and protein intake. A lower risk of PIH was calculated for women whose dietary habits included fruits and legumes. Measures with which to ensure proper nutrition education are needed to obtain good health and pregnancy outcomes. PIH is a multifactorial disease with an unclear etiology, and the findings of this study will serve as a baseline for future studies in this field.
Keywords: Nutrition; pregnancy-induced hypertension; health; Sudan.
The impact of systemic hypertension on outcomes in hospitalized COVID-19 patients – a systematic review
Authors: Ayodele Ogunmodede James , Jane Ogunmodede Adebusola , Folasade Dele-Ojo Bolade , Abiola Yusuf Idris , Abiodun Akintunde Adeseye , Akeem Bolarinwa Oladimeji , Peter Omojasola Taiye , Adeola Katibi Ibraheem , Babatunde Omotoso Ayodele 
Published: March 2023

Background: Several observational reports from different parts of the world have shown that systemic hypertension (hypertension) was the single commonest comorbid condition in hospitalized COVID-19 patients. Hypertension is also the most prevalent comorbidity reported among patients who developed severe disease, were admitted to Intensive Care Unit, needed mechanical ventilatory support, or who died on admission. The objective of this systematic review is to study the association between hypertension and specific clinical outcomes of COVID-19 disease which are- development of severe COVID-19 disease, need foradmission in the intensive care unit (ICU) or critical care unit (CCU), need for mechanical ventilation or death
Methods: We searched the PubMed, SCOPUS, and Google Scholar databases up till June 28, 2020 for original research articles that documented the risk factors of mortality in patients with COVID-19 using the PRISMA guideline.
Results: One hundred and eighty-two articles were identified using pre-specified search criteria, of which 33 met the study inclusion criteria. Only three were prospective studies. Most studies documented hypertension as the most prevalent comorbidity. The association of hypertension with development of severe COVID-19 disease was not conclusive, majority of studies however found an associated with mortality.
Conclusion: Hypertension affects the clinical course and outcome of COVID-19 disease in many cohorts. Prospective studies are needed to further understand this relationship.
Keywords: Hypertension and COVID-19; SARS –Cov-2; severity; mortality; ICU care; mechanical ventilation.
Curculigoside attenuates Helicobacter pylori-induced inflammation and apoptosis of gastric mucosal epithelial cells via NF-κB pathway
Authors: Li Yongjian , Su Xiaoyan 
Published: March 2023

Purpose: To investigate the possible effects and mechanisms of action of curculigoside (Cur) on gastric ulcers.
Methods: Human gastric mucosal epithelial GES-1 cells were infected with Helicobacter pylori and then treated with Cur. Cell counting kit 8 (CCK-8), flow cytometry, and immunofluorescence assays were used to investigate the effect of Cur on cell viability and apoptosis after exposure to H. pylori. Inflammation status and reactive oxygen species (ROS) were assessed using enzyme-linked immunoassay (ELISA) and dichlorodihydrofluorescein (DCF) staining, respectively, while immunoblot and immunofluorescence assays were performed to determine the effect of Cur on the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) pathway.
Results: Cur significantly increased H. pylori-induced cell viability and inhibited H. pylori-induced inflammatory cytokine production (p < 0.01). Furthermore, Cur significantly suppressed H. pylori-induced ROS production and apoptosis (p < 0.01). Through the NF-κB pathway, Cur attenuated H. pylori-induced inflammation and apoptosis of gastric mucosal epithelial cells.
Conclusion: In H. pylori infection, Cur treatment increases cell viability, reduces inflammatory cytokine production, suppresses ROS production, and inhibits apoptosis via NF-κB pathway. Further investigation using whole animal experiments would be needed to establish the role of Cur in the management of H. pylori-induced gastric ulcers.
Chikusetsu saponin IVA induces apoptosis and mitochondrial dysfunction of benign prostatic hyperplasia epithelial cell line (BPH-1) by inhibiting JAK/STAT3 signaling pathway
Authors: Gao Jian , Zhang Yuan , Li Lei 
Published: March 2023

Purpose: To determine the potential effect of Chikusetsu saponin IVA (CS-IVA) on benign prostatic hyperplasia (BPH), as well as the mechanism of action.
Methods: Benign prostatic hyperplasia epithelial cell response to treatment by CS-IVA was evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), colony formation assay, and cell cycle analysis. Flow cytometry and immunoblot assay were used to assess the effect of CS-IVA on cell apoptosis. Mitochondrial damage was examined by JC-1 staining and immunoblot, while immunoblot assay was also performed to determine the effect of CS-IVA on JAK/STAT3 pathway.
Results: CS-IVA inhibited the growth and cycle progression of BPH-1 cell but promoted cell apoptosis (p < 0.01). It also exacerbated mitochondrial damage in BPH-1 cell lines (p < 0.01). With regard to the mechanism of action, CS-IVA inhibited JAK/STAT3 pathway in BPH-1 cells (p < 0.01).
Conclusion: CS-IVA induces apoptosis and mitochondrial dysfunction of BPH-1 cells by inhibiting JAK/STAT3 pathway, and thus it is a potential drug for the treatment of BPH. However, in vivo studies on the effect of CS-IVA are are required to validate these results
Improving Health WSN with Distinguished Cloud Computing for Multi-Sensor Analytics
Authors: Mirza Baig Moiz , Sonekar Dr.Shrikant 
Published: March 2023

In the twenty-first century, automation has become more prevalent in large part due to the Internet of Things (IoT). The integration of IoT, Wireless Sensor Networks (WSNs) and health monitoring system with multi-cloud environment can optimize a lot of parameters like bandwidth, communication protocols and redundancy of the sensor network. The proposed architecture is introduced keeping in mind the current health infrastructure and monitoring system with different types of network framework. We have also discussed about machine to machine protocols for health monitoring with common entities linked with building communication protocols. The sensors data analytics carried out can sustain multi-level computation is the idea behind this research prospect to give greater depth about direct applicability in multi cloud sensor communication protocols. The offered prototype, when modelled with the unique communication system, produces a more efficient model than the standard way, with a system that is 98 percent more accurate.
Pengaruh Kompensasi dan Stres Kerja terhadap Kinerja Karyawan melalui Gender sebagai Variabel Kontrol
Authors: Welson Welson , Simanjuntak Jontro 
Published: March 2023

Pemberian jabatan rangkap adalah hal biasa di dunia kerja, karena perusahaan ingin mewujudkan efisiensi dan efektivitas penggunaan sumber daya mereka. Pemberian kompensasi kepada karyawan merupakan suatu bentuk balas jasa atas kontribusinya. Namun, kebijakan ini dapat membuat stres bagi karyawan. Penelitian dilakukan untuk menganalisis pengaruh kompensasi dan stres kerja terhadap kinerja karyawan PT Buana Logistik Mandiri Sukses melalui gender sebagai variabel kontrol. Metode penelitian ini adalah penelitian kuantitatif dengan analisis jalur. Seluruh populasi sebanyak 103 orang dijadikan sampel atau metode sampling jenuh. Pengumpulan data dilakukan dengan menyebarkan kuesioner kepada responden. Hasil dari penelitian ini adalah variabel kompensasi berpengaruh langsung terhadap kinerja karyawan, stres kerja berpengaruh langsung terhadap kinerja karyawan, variable kompensasi secara tidak langsung berpengaruh tidak signifikan terhadap kinerja karyawan melalui gender sebagai variable control. variable stress kerja secara tidak langsung berpengaruh tidak signifikan terhadap kinerja karyawan melalui gender sebagai variable control. Kesimpulan berdasarkan hasil penelitian adalah bahwa upah dan stres kerja mempengaruhi kinerja secara langsung maupun tidak langsung dengan jenis kelamin sebagai variabel kontrol.