bluuebunny/crossref_metadata_2025_split huggingface dataset:
ExpressAnalyst: A unified platform for RNA-sequencing analysis in non-model species
Authors: Liu Peng , Ewald Jessica , Pang Zhiqiang , Legrand Elena , Jeon Yeon Seon , Sangiovanni Jonathan , Hacariz Orcun , Zhou Guangyan , Head Jessica A. , Basu Niladri , Xia Jianguo 
Published: May 2023

AbstractThe increasing application of RNA sequencing to study non-model species demands easy-to-use and efficient bioinformatics tools to help researchers quickly uncover biological and functional insights. We developed ExpressAnalyst (www.expressanalyst.ca), a web-based platform for processing, analyzing, and interpreting RNA-sequencing data from any eukaryotic species. ExpressAnalyst contains a series of modules that cover from processing and annotation of FASTQ files to statistical and functional analysis of count tables or gene lists. All modules are integrated with EcoOmicsDB, an ortholog database that enables comprehensive analysis for species without a reference transcriptome. By coupling ultra-fast read mapping algorithms with high-resolution ortholog databases through a user-friendly web interface, ExpressAnalyst allows researchers to obtain global expression profiles and gene-level insights from raw RNA-sequencing reads within 24 h. Here, we present ExpressAnalyst and demonstrate its utility with a case study of RNA-sequencing data from multiple non-model salamander species, including two that do not have a reference transcriptome.
A multi-site study of the relationship between photoperiod and ovulation rate using Natural Cycles data
Authors: Shanmugam Divya , Espinosa Matthew , Gassen Jeffrey , van Lamsweerde Agathe , Pearson Jack T. , Benhar Eleonora , Hill Sarah 
Published: May 2023

AbstractMany species exhibit seasonal patterns of breeding. Although humans can shield themselves from many season-related stressors, they appear to exhibit seasonal patterns of investment in reproductive function nonetheless, with levels of sex steroid hormones being highest during the spring and summer months. The current research builds on this work, examining the relationship between day length and ovarian function in two large samples of women using data from the Natural Cycles birth control application in each Sweden and the United States. We hypothesized that longer days would predict higher ovulation rates and sexual motivation. Results revealed that increasing day length duration predicts increased ovulation rate and sexual behavior, even while controlling for other relevant factors. Results suggest that day length may contribute to observed variance in women’s ovarian function and sexual desire.
Active learning applied to automated physical systems increases the rate of discovery
Authors: Shields Michael D. , Gurley Kurtis , Catarelli Ryan , Chauhan Mohit , Ojeda-Tuz Mariel , Masters Forrest J. 
Published: May 2023

AbstractActive machine learning is widely used in computational studies where repeated numerical simulations can be conducted on high performance computers without human intervention. But translation of these active learning methods to physical systems has proven more difficult and the accelerated pace of discoveries aided by these methods remains as yet unrealized. Through the presentation of a general active learning framework and its application to large-scale boundary layer wind tunnel experiments, we demonstrate that the active learning framework used so successfully in computational studies is directly applicable to the investigation of physical experimental systems and the corresponding improvements in the rate of discovery can be transformative. We specifically show that, for our wind tunnel experiments, we are able to achieve in approximately 300 experiments a learning objective that would be impossible using traditional methods.
Clinical outcomes of a new four-haptic hydrophobic presbyopia-correcting intraocular lens
Authors: Whang Woong-Joo , Kim Tae-im , Tchah Hungwon , Koh Kyungmin 
Published: May 2023

AbstractA new presbyopia-correcting intraocular lens (IOL) combining bifocal and extended-depth-of-focus profiles (Symbiose: Artis Symbiose Plus; Cristalens Industrie, Lannion, France) was introduced. We compared the output with that of a standard monofocal IOL (PL E: Artis PL E). The two four-haptic hydrophobic IOLs were made of the same material from the same company. Cataract patients bilaterally implanted with either PL E or Symbiose between November 2021 and August 2022 were reviewed. The principal measures of the postoperative results were uncorrected distance visual acuity (UDVA); corrected distance VA (CDVA); uncorrected intermediate VA; uncorrected near VA; objective optical quality; and distance-corrected defocus curves. This study included forty-eight patients (96 eyes), with 22 and 26 patients (44 and 52 eyes, respectively) being implanted with PL E and Symbiose, respectively. All patients received the same type of IOL implanted in both eyes. The average age of patients was 70.9 ± 7.1 and 60.0 ± 8.5 years in PL E and Symbiose groups, respectively, with significantly younger patients in Symbiose group (p < 0.001). Both IOLs displayed excellent UDVA and CDVA with no statistical difference (p = 0.081 (monocular UDVA), p = 0.599 (monocular CDVA), p = 0.204 (binocular UDVA), and p = 0.145 (binocular CDVA)). In comparison with PL E group, Symbiose group showed significantly superior postoperative intermediate and near VA (p < 0.001). PL E group showed significantly superior objective optical quality compared with Symbiose group (p < 0.001). Symbiose provides a continuous range of vision that ensures a seamless transition from far to near with no discontinuity. It also delivers a smooth defocus curve with a larger landing area than the PL E. But the objective optical quality was better in PL E.
Enhancement growth, water use efficiency and economic benefit for maize by drip irrigation in Northwest China
Authors: Liu Mengjie , Liang Fei , Li Quansheng , Wang Guodong , Tian Yuxin , Jia Hongtao 
Published: May 2023

AbstractThe application of drip irrigation has been paid more and more attention, but there was lack of systematic comparative analysis between drip irrigation and conventional border irrigation method for maize, currently. A 7-year field study from 2015 to 2021 evaluated the effects of drip irrigation (DI, 540 mm) or conventional border irrigation method (BI, 720 mm) on maize growth, water use efficiency (WUE) as well as profitability. The results showed the plant height, leaf area index, yield, WUE and economic benefit of maize with DI had significantly higher than BI. The dry matter translocation, the dry matter transfer efficiency and contribution of dry matter translocation to grain with DI showed significant increase of 27.44%, 13.97% and 7.85% compared to BI, respectively. In comparison to conventional border irrigation, the yield of drip irrigation increased by 14.39%, as well as WUE and irrigation water use efficiency (IWUE) increased by 53.77% and 57.89%. The net return and economic benefit of drip irrigation was 1998.87 and 756.58 USD$ hm−1 higher than that of BI. Drip irrigation increased net return and benefit/cost ratio by 60.90% and 22.88% compared with BI. These results demonstrate that the drip irrigation can effectively improve the growth, yield, WUE and economic benefit of maize in northwest China. Therefore, drip irrigation can be used for maize cultivation to increase crop yield and WUE in northwest China, which has cut down on irrigation water about 180 mm.
Yawning and scratching contagion in wild spider monkeys (Ateles geoffroyi)
Authors: Valdivieso-Cortadella Sara , Bernardi-Gómez Chiara , Aureli Filippo , Llorente Miquel , Amici Federica 
Published: May 2023

AbstractBehavioural contagion is a widespread phenomenon in animal species, which is thought to promote coordination and group cohesion. Among non-human primates, however, there is no evidence of behavioural contagion in Platyrrhines (i.e. primates from South and Central America) yet. Here, we investigated whether behavioural contagion is also present in this taxon, by assessing yawning and scratching contagion in a wild group (N = 49) of Geoffroy’s spider monkeys (Ateles geoffroyi). We conducted focal samples to examine whether individuals observing the triggering event (i.e. a naturally occurring yawning or scratching event in the group) would be more likely to yawn or scratch in the following 3 min, as compared to individuals who did not observe the triggering event. We ran generalized linear mixed models using a Bayesian approach, and found that the probability of yawning and scratching was higher for individuals observing others yawning and scratching, respectively, as compared to individuals who did not observe such an event. Behavioural contagion did not vary depending on the observer’s sex, kinship or relationship quality with the individual performing the triggering event. These findings provide the first evidence for yawning and scratching contagion in a wild group of spider monkeys, and importantly contribute to the debate about the evolutionary origins of behavioural contagion in primates.
The Relationship Between Early Spelling and Decoding
Authors: McNeill Brigid Catherine , Gillon Gail , Gath Megan 
Published: May 2023

Purpose:
This study aimed to elucidate the nature of the relationship between the development of decoding and encoding skills in the first year at school.

Method:
The foundational literacy skills of one hundred eighty 5-year-old children were examined on three occasions over their first year of literacy instruction. Participants received the same literacy curriculum. The predictive utility of early spelling on later reading accuracy, reading comprehension, and spelling outcomes was explored. Performance on matched nonword spelling and nonword reading tasks was also used to compare the use of particular graphemes across these contexts.

Results:
Regression and path analyses showed that nonword spelling was a unique predictor of later (end of year) reading and played a facilitative role in the emergence of decoding. Children were generally more accurate on spelling than decoding for the majority of graphemes evaluated in the matched tasks. Factors such as position of the grapheme in the word, complexity of the grapheme (e.g., digraph vs. graph), and the scope and sequence of the literacy curriculum influenced children's accuracy for specific graphemes.

Conclusions:
The development of phonological spelling appears to play a facilitatory role in early literacy acquisition. Implications for the assessment and teaching of spelling in the first year of schooling are explored.
Centralized model‐predictive cooperative and adaptive cruise control of automated vehicle platoons in urban traffic environments
Authors: Klingbeil Xiaonan , Wegener Marius , Zhou Haibo , Herrmann Florian , Andert Jakob 
Published: May 2023

AbstractRecent research has demonstrated that cooperative and automated driving functions can improve traffic efficiency and safety. Traffic efficiency can be increased and the overall vehicle energy consumption can be reduced through cooperative driving functions not only on the highway, but also in urban areas. To this end, this paper presents a linear model predictive control (MPC) algorithm for the optimization of velocity trajectories of vehicles in a platoon in an urban traffic environment. A novel centralized approach is implemented to optimize the total energy consumption of all vehicles while improving traffic efficiency. To solve the optimal control problem, for the first time, an additional data‐driven velocity prediction model of the vehicle in front of the platoon is used to consider the influence of realistic prediction errors when evaluating the developed control strategy in a vehicle simulation environment. The simulated total energy consumption is compared with a rule‐based cooperative adaptive cruise control (CACC) algorithm. Furthermore, the traffic density and the platoon string stability, the robustness and computer time of the centralized approach are also included in the evaluation. Simulation results indicate that, considering all evaluation criteria, the centralized cooperative control strategy can improve energy efficiency by up to 15% in the investigated urban scenario.
Value of [18F]FDG PET/CT in diagnosis and management of spondylodiscitis
Authors: Lapa Constantin , Rischpler Christoph , Bundschuh Ralph Alexander , Dierks Alexander , Lang Sigmund , Wassilew Georgi , Alt Volker 
Published: May 2023

AbstractVertebral osteomyelitis is the third most common form of osteomyelitis in patients over 50 years of age.Whereas prompt (pathogen-directed) therapy is crucially associated with better outcomes, the heterogeneous clinical presentation of disease with unspecific symptoms often delays adequate treatment initiation. Diagnosis requires a careful investigation of medical history, clinical findings and diagnostic imaging, including magnetic resonance imaging and nuclear medicine techniques.Due to its high sensitivity, [18F]FDG PET/CT is becoming increasingly important in diagnosis and management of spondylodiscitis, especially in the postoperative setting with presence of spinal hardware or other implantable devices in which MRI is limited.
Erfahrungen von Vätern zu Schwangerschaft, Geburt und
Wochenbett während der Covid-19 Pandemie
Authors: Sebinger Marylin Sarah , Schildberger Barbara 
Published: May 2023

Zusammenfassung
Einleitung Zur Reduktion möglicher Ansteckungsgefahren durch
SARS-CoV-2 wurden in allen Bereichen des öffentlichen Lebens
Zugangsbeschränkungen eingeführt. In den extra- und intramuralen
Gesundheitseinrichtungen betreffen diese Maßnahmen in weiten Teilen auch
Schwangere, Gebärende und Wöchnerinnen und auch deren
Partner*innen. Ziel dieser Studie ist es, die Erfahrungen werdender
Väter vor dem Hintergrund pandemiebedingter Einschränkungen zu
erheben und zu reflektieren.
Methode Einem qualitativen Studiendesign folgend wurden 11
leitfadengestützte Interviews mit Vätern, die eine Geburt
während der Covid-19 Pandemie erlebt haben, im Juni 2022
durchgeführt. Auf Basis einer Inhaltsanalyse nach Mayring wurden
Kategorien abgeleitet, die Ergebnisse aus den Interviews einem höheren
Abstraktionsniveau übergeführt und interpretiert.
Ergebnisse Die Väter fühlten sich aufgrund der
pandemiebedingten Restriktionen während der Schwangerschaft, der Geburt
und des stationären Aufenthaltes der Frauen ausgegrenzt, gestresst und
verunsichert. Wenngleich für die Maßnahmen Verständnis
aufgebracht werden konnte, war die Angst vorherrschend, die Partnerin nicht
ausreichend unterstützen zu können und zu wenig
Möglichkeiten des Bondings mit dem Neugeborenen zu haben.
Schlussfolgerung Die Untersuchungsergebnisse machen deutlich, dass
während der Covid-Pandemie die Notwendigkeit strukturierter
Rahmenbedingungen zur Einbindung von Begleitpersonen im geburtshilflichen
Setting verstärkt Beachtung finden soll. Eine aktiv gestaltete Teilnahme
der Partner*innen an der Schwangerschafts- und Geburtsbegleitung soll
gefördert werden.
Stellenwert ausgewählter Trainingsprinzipien innerhalb eines
körperlichen Trainings zur Frakturprophylaxe
Authors: von Stengel Simon , Kohl Matthias , Jakob Franz , Kerschan-Schindl Katharina , Lange Uwe , Peters Stefan , Thomasius Friederike , Uder Michael , Fröhlich Michael , Schöne Daniel , Kemmler Wolfgang , Shojaa Mahdieh 
Published: May 2023

ZusammenfassungTrainingsprinzipien werden als konkrete und leitende Handlungsanweisung
für ein körperliches Training angesehen und beziehen sich auf
alle übergeordeten Aspekte des Trainings weitestgehend
unabhängig von der fokussierten Zielgröße. Relevanz
für Gresundheits- und Rehabilitationssport haben primär
Prinzipien zur Auslösung und Sicherung von Anpassungseffekten.
Während das Prinzip des überschwelligen Reizes und dessen
Aufrechterhaltung („progressive overload“) im
gesundheitsorientierten Trainingsprozess meist Berücksichtigung findet,
werden Trainingsprinzipien, die in Zusammenhang mit der Spezifität,
Individualisierung und Variation stehen sehr oft nicht oder nicht mit der
nötigen Aufmerksamkeit adressiert. Insbesondere eine hohe
Spezifität des Trainings u. a. im Sinne der Auswahl geeigneter
Trainingsinhalte zur Realisierung des dezidierten Trainingszieles sowie eine
hoher Individualisierungsgrad u. a. durch Vorgabe relevanter
Trainingsziele und Monitoring der individuellen Leistungsentwicklung sind
Schlüsselgrößen erfolgreicher Trainingsprotokolle. Eine
kontinuierliche Trainingsdurchführung mit Detrainingsphasen von weniger
als 4–6 Wochen, sollte bei einem körperlichen Training zur
Frakturprophylaxe ebenfalls Berücksichtigung finden. Schließlich
können bewährte Trainingsprinzipien des Leistungssports die mit
Periodisierung/Zyklisierung in Verbindung stehen relativ unproblematisch
und sinnvoll in gesundheitsorientierten Trainingsprogrammen Verwendung
finden.
Echogenicity of Brain Structures in Huntington’s Disease Patients Evaluated by Transcranial Sonography – Magnetic Resonance Fusion Imaging using Virtual Navigator and Digital Image Analysis
Authors: Kozel Jiří , Školoudík David , Ressner Pavel , Michalčová Patricie , Dušek Petr , Hanzlíková Pavla , Dvořáčková Nina , Heryán Tomáš , Bártová Petra 
Published: May 2023

Abstract
Purpose Transcranial sonography (TCS) magnetic resonance (MR) fusion imaging and digital image analysis are useful tools for the evaluation of various brain pathologies. This study aimed to compare the echogenicity of predefined brain structures in Huntington’s disease (HD) patients and healthy controls by TCS-MR fusion imaging using Virtual Navigator and digitized image analysis.
Materials and Methods The echogenicity of the caudate nucleus (CN), substantia nigra (SN), lentiform nucleus (LN), insula, and brainstem raphe (BR) evaluated by TCS-MR fusion imaging using digitized image analysis was compared between 21 HD patients and 23 healthy controls. The cutoff values of echogenicity indices for the CN, LN, insula, and BR with optimal sensitivity and specificity were calculated using receiver operating characteristic analysis.
Results The mean echogenicity indices for the CN (67.0±22.6 vs. 37.9±7.6, p<0.0001), LN (110.7±23.6 vs. 59.7±11.1, p<0.0001), and insula (121.7±39.1 vs. 70.8±23.0, p<0.0001) were significantly higher in HD patients than in healthy controls. In contrast, BR echogenicity (24.8±5.3 vs. 30.1±5.3, p<0.001) was lower in HD patients than in healthy controls. The area under the curve was 90.9%, 95.5%, 84.1%, and 81.8% for the CN, LN, insula, and BR, respectively. The sensitivity and specificity were 86% and 96%, respectively, for the CN and 90% and 100%, respectively, for the LN.
Conclusion Increased CN, LN, and insula echogenicity and decreased BR echogenicity are typical findings in HD patients. The high sensitivity and specificity of the CN and LN hyperechogenicity in TCS-MR fusion imaging make them promising diagnostic markers for HD.
Low-Dose Aspirin during Pregnancy and Postpartum Bleeding
Authors: White Kelsey J. , Son Moeun , Lundsberg Lisbet S. , Culhane Jennifer F. , Partridge Caitlin , Reddy Uma M. , Merriam Audrey A. 
Published: May 2023

Objective This study aimed to investigate whether aspirin 81 mg daily for preeclampsia prevention is associated with increased risk of postpartum blood loss at the time of delivery.
Study Design This is a retrospective cohort study performed at a tertiary hospital from January 2018 to April 2021. Data were extracted from the electronic medical record. Patients prescribed low-dose aspirin (LDA) were compared with patients who were not. The primary outcome was a composite of postpartum blood loss, defined as: estimated blood loss (EBL) >1,000 mL, documentation of International Classification of Diseases-9/-10 codes for postpartum hemorrhage (PPH), or red blood cell (RBC) transfusion. Bivariate analysis, and unadjusted and adjusted logistic regression modeling were performed.
Results Among 16,980 deliveries, 1,922 (11.3%) were prescribed LDA. Patients prescribed LDA were more likely to be >35 years old, nulliparous, obese, taking other anticoagulants, or have diagnoses of diabetes, systemic lupus erythematosus, fibroids, or hypertensive disease of pregnancy. After adjusting for potential confounders, the significant association between LDA use and the composite did not persist (adjusted odds ratio [aOR]: 1.1, 95% confidence interval [CI]: 1.0–1.3) nor did the association between EBL > 1,000 mL (aOR: 1.0, 95% CI: 0.9–1.3) and RBC transfusion (aOR: 1.3, 95% CI: 0.9–1.7). The association between LDA and PPH remained significant (aOR: 1.3, 95% CI: 1.1–1.6). Patients who discontinued LDA <7 days prior to delivery had an increased risk of the postpartum blood loss composite compared discontinuation ≥7 days (15.0 vs. 9.3%; p = 0.03).
Conclusion There may be an association between LDA use and increased risk of postpartum bleeding. This suggests that use of LDA outside the recommended guidelines should be cautioned and further investigation is needed to determine its ideal dosing and timing of discontinuation.
Key Points
Intracranial Dural Arteriovenous Fistulas: A Systematic Approach—Diagnosis, Classification, and Endovascular Treatment
Authors: Sammoud Skander , Hammami Nadia 
Published: May 2023

AbstractIntracranial dural arteriovenous fistulas (DAVFs) are rare lesions accounting for 10 to 15% of intracranial arteriovenous malformations. They involve an anomalous shunt between meningeal arteries, intracranial (venous sinuses and/or cortical veins), or medullary veins. The DAVFs are usually acquired, implying previous aggression of the dura mater. Thus, they are associated with dural sinus thrombosis, previous craniotomy, and trauma. However, they are idiopathic in most instances and have no evident cause. Their clinical presentation is variable, with symptoms depending on their location and venous drainage pattern. However, lesions with cortical venous drainage have the highest risk of causing the most significant morbidity and mortality. High clinical suspicion alongside noninvasive cross-sectional imaging techniques such as computed tomography and magnetic resonance imaging help establish the diagnosis. Digital subtraction angiography is the gold standard for diagnosis and accurate classification, permitting the evaluation of the feeding vessels, cortical venous drainage, and venous ectasia. Accordingly, a prompt diagnosis and precise classification of these lesions are essential. Endovascular treatment is nowadays the primary therapeutic modality for DAVFs. The access route can be divided into transarterial, transvenous, and combined approaches based on angioarchitecture, venous drainage model, and location. Surgical resection and stereotactic radiosurgery may be considered in some cases. A personalized case-by-case approach accomplishes a high complete treatment grade with a low complication rate. This review highlights the epidemiology, pathogenesis, clinical presentation, classification, diagnosis, and endovascular treatment of patients with intracranial DAVFs.