bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gill disorders in fish: Lessons from poxvirus infections
Authors: Zawisza Maria , Chadzinska Magdalena , Steinhagen Dieter , Rakus Krzysztof , Adamek Mikołaj 
Published: June 2023

AbstractGill disorders are responsible for substantial losses in the aquaculture industry. This is because gills are delicate and anatomically complex tissues, responsible for maintaining homeostasis in fish by being involved in many important physiological processes. Pathogens that infect gills, together with chemical irritants can modify the function of this organ and seriously affect fish health often leading to mass mortality. Since many fish pathogens affect not only gills, but also other organs, the impact of gill disorders alone on disruption of fish homeostasis is difficult to determine. There are, however, fish poxviruses that have a high affinity for the gills: carp edema virus (CEV), salmon gill poxvirus (SGPV) and Plecoglossus altivelis poxvirus (PaPV). These poxviruses could therefore help in defining the principal characteristics of gill disorders. Thus, the present study reviews the effects of gill disorders caused by CEV, SGPV and PaPV on fish health. CEV and SGPV infect fish species that are very important for global aquaculture: common carp (Cyprinus carpio) and Atlantic salmon (Salmo salar), and induce gill pathology that has a very negative impact on respiratory and osmoregulatory functions, nitrogenous waste excretion and energy metabolism. Furthermore, we highlight that a disruption of these metabolic processes increases stress response and results in immunosuppression, exposing fish to secondary infections. Finally, this review emphasises the importance of maintaining gill health for fish in order to perform well in aquaculture settings as well as underlining that gill health should be focused on in fish farming.
The 1990s party realignment of U.S. presidential elections: Geographic sorting of counties by blue or red
Authors: Aistrup Joseph A. , Mahato Binita , Morris John C. 
Published: June 2023

AbstractIntroductionThis paper addresses the issue of partisan polarization in the U.S. in presidential voting at the county level. The literature on the growing partisan sorting and/or polarization is extensive, and controversies are pervasive. This paper focuses on the timing and sequence of changes in partisan vote shares at the county level from 1952 through the 2020 election.MethodsWe apply confirmatory factor analysis to identify the structures of partisan competition in counties from 1952 to 2020, and multiscale geographically weighted regression (MGWR) to uncover the social processes that influence the growing partisan polarization in the U.S.ResultsWe find that the growing partisan segregation coincides with the beginning of a secular change in the structure of partisan competition at the presidential level among counties that has intensified over the past quarter century. Polarization, segregation of partisans in communities, and a rise in sectionalism are the predominant characteristics of this new alignment.ConclusionThis study confirms a secular realignment in the structure of party competition among counties in presidential elections starting in 1996 and solidifying in 2008 when Obama is elected. The segregation of counties by dark shades of red or blue is the unique fingerprint of this new alignment that we call the "Geographic Sort" alignment.
Acute Chagas disease associated with ingestion of contaminated food in Brazilian western Amazon
Authors: de Sousa Débora Raysa Teixeira , de Oliveira Guerra Jorge Augusto , Ortiz Jessica Vanina , do Nascimento Couceiro Katia , da Silva e Silva Monica Regina Hosanahh , Jorge Brandão Alba Regina , Guevara Elsa , Arcanjo Ana Ruth Lima , de Oliveira Júnior Edival Ferreira , Smith‐Doria Susan , Mwangi Victor Irungu , Morais Rômulo Freire , Silva George Allan Villarouco , Molina Israel , Silveira Henrique , Ferreira João Marcos Bemfica Barbosa , Guerra Maria das Graças Vale Barbosa 
Published: June 2023

AbstractObjectiveTo describe clinical, epidemiological and management information on cases of acute Chagas disease (ACD) by oral transmission in the state of Amazonas in western Amazon.MethodsManual and electronic medical records of patients diagnosed with ACD at the Fundação de Medicina Tropical Doutor Heitor Vieira Dourado (FMT‐HVD) were included.ResultsThere were 147 cases of acute CD registered from 10 outbreaks that occurred in the state of Amazonas between 2004 and 2022. The transmission pathway was through oral route, with probable contaminated palm fruit juice (açaí and/or papatuá), and involved people from the same family, friends or neighbours. Of 147 identified cases, 87 (59%) were males; cases were aged 10 months to 82 years. The most common symptom was the febrile syndrome (123/147; 91.8%); cardiac alterations were present in 33/100 (33%), (2/147; 1.4%) had severe ACD with meningoencephalitis, and 12 (8.2%) were asymptomatic. Most cases were diagnosed through thick blood smear (132/147; 89.8%), a few (14/147; 9.5%) were diagnosed by serology and (1/147; 0.7%) by polymerase chain reaction (PCR) and blood culture. In all these outbreaks, 74.1% of the patients were analysed by PCR, and Trypanosoma cruzi TcIV was detected in all of them. No deaths were recorded. The incidence of these foci coincided with the fruit harvest period in the state of Amazonas.ConclusionThe occurrence of ACD outbreaks in the Amazon affected individuals of both sexes, young adults, living in rural and peri‐urban areas and related to the consumption of regional foods. Early diagnosis is an important factor in surveillance. There was a low frequency of cardiac alterations. Continuous follow‐up of most patients was not carried out due to difficulty in getting to specialised centres; therefore, little is known about post‐treatment.
Newcastle disease virus LaSota strain induces apoptosis and activates the TNFα/NF‐κB pathway in canine mammary carcinoma cells
Authors: Wang Jiahui , Li Mengqing , Li Meng 
Published: June 2023

AbstractSpontaneous canine mammary carcinomas (CMCs) have been widely considered a good research model for human breast cancers, which brings much attention to CMCs. In recent years, the oncolytic effect of Newcastle disease virus (NDV) on cancer cells has been widely studied, but its effect on CMCs is still unclear. This study aims to investigate the oncolytic effect of NDV LaSota strain on canine mammary carcinoma cell line (CMT‐U27) in vivo and in vitro. The in vitro cytotoxicity and immunocytochemistry experiments showed that NDV selectively replicated in CMT‐U27 cells, and inhibited cell proliferation and migration but not in MDCK cells. KEGG analysis of transcriptome sequencing indicated the importance of the TNFα and NF‐κB signalling pathways in the anti‐tumour effect of NDV. Subsequently, the significantly increased expression of TNFα, p65, phospho‐p65, caspase‐8, caspase‐3 and cleaved‐PARP proteins in the NDV group suggested that NDV induced CMT‐U27 cells apoptosis by activating the caspase‐8/caspase‐3 pathway and the TNFα/NF‐κB signalling pathway. Nude mice tumour‐bearing experiments showed that NDV could significantly decrease the growth rate of CMC in vivo. In conclusion, our study demonstrates the effective oncolytic effects of NDV on CMT‐U27 cells in vivo and in vitro, and suggests NDV as a promising candidate for oncolytic therapy.
Fatigue Strength Evaluation of Cu–Ni–Si Alloy Strips
Authors: Mita Natsuhiro , Omiya Masaki , Watanabe Shingo , Ishizaka Norio 
Published: June 2023

Abstract
This study investigates the mean stress effect on the fatigue strength and the mean stress effect criterion that best represents this effect in Cu–Ni–Si alloy strips using a new test method. Since the cyclic bending fatigue test based on the fatigue test standard for Japan Copper and Brass Association for understanding the fatigue characteristics of Cu–Ni–Si alloy strips needs many test times, a new test method to conduct effectively was examined and developed, and after confirming its validity, the mean stress effect criterion was identified using this method. The effect of surface electroplating on fatigue properties was also investigated. As a result, it was confirmed that the mean stress effect criterion on the fatigue strength of Cu–Si–Ni alloy strips was represented well by the elliptic line. The effect of surface electrolytic plating on fatigue properties was found to be strongly influenced by surface roughness rather than Young’s modulus or hardness of the constituent plating.
A Novel Method for the Determination of Blade Vibration Stress Considering the Change in Blade Tip Timing Sensing Position
Authors: Zhang Xiaojie , Wang Yanrong , Hu Dianyin , Wang Rongqiao 
Published: June 2023

Abstract
Blade tip timing (BTT) technology is concerned with the estimation of turbomachinery blade stress. The stress is determined from BTT data by relating the measured tip displacement to the stress via finite element (FE) models based on the sensing position. However, the correlation of BTT data with FE predictions involves a number of uncertainties. One of the main ones is the effective positions detected by sensors may deviate from their nominal position due to the blade deformation, which will yield deceptive calibration factors. To deal with this problem, a novel method based on the amplitude ratio and virtual displacement optimization under the distance constraints of sensors installed in different axial positions is proposed to determine the accuracy calibration factors and sensing positions. It realizes the identification of sensing positions without the information of static deformation, and overcomes the inapplicability of the corrected displacement to bending modes. Both synchronous and asynchronous vibrations of five typical vibration modes are discussed to illustrate the applicability of this method. The results show that this method has better performance than traditional method. The prediction errors of bending modes are reduced from 20 ∼ 30% to 7%, and the maximum error of other modes is reduced from 72% to 23%. In addition, sensitivity analysis is performed to investigate the influence of vibration levels and mode shape inaccuracies. Results demonstrate the great potential of this method in vibration stress determination.
Community- and genome-based evidence for a shaping influence of redox potential on bacterial protein evolution
Authors: Dick Jeffrey M. , Meng Delong 
Published: June 2023

ABSTRACT

Despite deep interest in how environments shape microbial communities, whether redox conditions influence the sequence composition of genomes is not well known. We predicted that the carbon oxidation state (
Z
C
) of protein sequences would be positively correlated with redox potential (Eh). To test this prediction, we used taxonomic classifications for 68 publicly available 16S rRNA gene sequence data sets to estimate the abundances of archaeal and bacterial genomes in river & seawater, lake & pond, geothermal, hyperalkaline, groundwater, sediment, and soil environments. Locally,
Z
C
of community reference proteomes (i.e., all the protein sequences in each genome, weighted by taxonomic abundances but not by protein abundances) is positively correlated with Eh corrected to pH 7 (Eh7) for the majority of data sets for bacterial communities in each type of environment, and global-scale correlations are positive for bacterial communities in all environments. In contrast, archaeal communities show approximately equal frequencies of positive and negative correlations in individual data sets, and a positive pan-environmental correlation for archaea only emerges after limiting the analysis to samples with reported oxygen concentrations. These results provide empirical evidence that geochemistry modulates genome evolution and may have distinct effects on bacteria and archaea.

IMPORTANCE
The identification of environmental factors that influence the elemental composition of proteins has implications for understanding microbial evolution and biogeography. Millions of years of genome evolution may provide a route for protein sequences to attain incomplete equilibrium with their chemical environment. We developed new tests of this chemical adaptation hypothesis by analyzing trends of the carbon oxidation state of community reference proteomes for microbial communities in local- and global-scale redox gradients. The results provide evidence for widespread environmental shaping of the elemental composition of protein sequences at the community level and establish a rationale for using thermodynamic models as a window into geochemical effects on microbial community assembly and evolution.
Thermal architecture of the Salmon River suture zone, Idaho, USA: Implications for the structural evolution of a ductile accretionary complex during arc-continent collision
Authors: Long Sean P. , Barba William K. , McKay Matthew P. , Soignard Emmanuel 
Published: June 2023

AbstractDocumenting the tectono-thermal evolution of the exhumed ductile portions of orogenic systems is critical for interpreting orogen dynamics. Here, we utilize Raman spectroscopy of carbonaceous material thermometry to quantify the thermal architecture of the Salmon River suture zone in west-central Idaho, USA, which records the Cretaceous collision of the Wallowa island arc terrane with North America. We integrate this thermal architecture with published structural interpretations, geochronology, and pressure-temperature-time histories to interpret the evolution of deformation during arc-continent collision in this portion of the North America Cordillera. Mean peak temperatures within four, ~1–3-km-thick, penetratively deformed thrust sheets in the western part of the suture zone decrease moving structurally downward from 652 ± 28 °C (Pollock Mountain thrust sheet), to 577 ± 30 °C (Rapid River thrust sheet), to 426 ± 32 °C (Morrison Ridge thrust sheet), to 358 ± 18 °C (Heavens Gate thrust sheet). These ductile thrust sheets are separated by 100–500-m-thick intervals of inverted temperatures that surround the mapped positions of thrust faults. We interpret the western part of the suture zone as a ductile accretionary complex that records the progressive underplating and top-to-the-west translation of ductile thrust sheets that were derived from the Wallowa terrane during ca. 144–105 Ma collision-related deformation. Accretion of ductile thrust sheets began at ~30–35 km depths and completed at depths of ~10–20 km. Rocks at all structural levels in the suture zone exhibit distributed ductile fabrics, but the inverted thermal gradients that surround the mapped positions of thrust faults suggest that the majority of top-to-the-west displacement was accommodated within 100–500-m-thick, high-strain, thrust-sense ductile shear zones.
Interventions to support medical trainee well-being when dealing with patient death: a scoping review protocol
Authors: Ibrahim Halah , Vetter Cecelia J , West Kelsey , Oyoun Alsoud Leen , Sorrell Sara 
Published: June 2023

IntroductionExisting literature demonstrates that medical students and residents experience complex emotions and substantial grief after patient deaths. Over time, this can lead to burnout and depression and adversely impact patient care. In response, medical schools and training programmes worldwide have developed and implemented interventions to help medical trainees to better cope with patient deaths. This manuscript provides a scoping review protocol that aims to systematically identify and document the published research reporting on the implementation or delivery of interventions to support medical students and residents/fellows in dealing with patient death.Methods and analysisA scoping review will be conducted following the Arksey-O’Malley five-stage scoping review method and the Scoping Review Methods Manual by the Joanna Briggs Institute. English language interventional studies published through 21 February 2023, will be identified in the following databases: MEDLINE, Scopus, Embase, Psych Info, Cochrane Database of Systematic Reviews, CINAHL and ERIC. Two reviewers will screen titles and abstracts and then independently screen full-text articles for inclusion. Two reviewers will assess the methodological quality of included studies using the Medical Education Research Study Quality Instrument. After extraction, data will be narratively synthesised. Experts in the field will be consulted to ensure the feasibility and relevance of the findings.Ethics and disseminationEthical approval is not required as all data will be collected from published literature. The study will be disseminated through publication in peer-reviewed journals and presentation at local and international conferences.
Association between housing damage, present bias and delayed-onset post-traumatic stress symptoms among older adults 9 years after a natural disaster
Authors: Hikichi Hiroyuki , Sawada Yasuyuki , Aida Jun , Kondo Katsunori , Kawachi Ichiro 
Published: June 2023

BackgroundPrevious studies suggest that experience of natural disasters may heighten present bias. Research also suggests that impaired self-control (in particular, heightened present bias) could be linked to delayed-onset post-traumatic stress symptoms (PTSS) among survivors of natural disasters. We examined a hypothesis that the association between disaster experiences and delayed-onset PTSS is mediated through present bias among older survivors of the 2011 Japan earthquake and tsunami.MethodsThe baseline survey was conducted for older adults who lived in a city located 80 km west of the epicentre 7 months before the disaster. Approximately 2.5 and 8.5 years after the disaster, we surveyed older survivors to assess the trajectory of PTSS (2230 participants). We implemented analyses by three analytical groups: (1) resilient versus delayed-onset, (2) resilient versus improved and (3) resilient versus persistent.ResultsLogistic regression models showed that major housing damage was linked to raised present bias in all analytical groups (OR 2.47, 95% CI 1.04 to 5.87; OR 2.75, 95% CI 1.20 to 6.29; OR 2.65, 95% CI 1.15 to 6.10, respectively). The present bias, however, was significantly associated with only delayed-onset PTSS (OR 2.05, 95% CI 1.14 to 3.69). In the group of resilient versus delayed onset, housing destruction was also associated with delayed-onset PTSS (OR 2.44, 95% CI 1.11 to 5.37), and the association was attenuated by present bias (OR 2.36, 95% CI 1.07 to 5.18).ConclusionsPresent bias could mediate the association between housing damage and delayed-onset PTSS among older survivors of a natural disaster.
Risk factors and immunomodulators use in steroid-refractory checkpoint inhibitor pneumonitis
Authors: Li Yanlin , Jia Xiaohui , Zhang Yajuan , Du Yonghao , Chang Yuzhu , Shen Yuan , Mao Ziyang , Liu Mengjie , Sun Hong , Guo Hui 
Published: June 2023

BackgroundCheckpoint inhibitor pneumonitis (CIP) that does not respond to corticosteroids is termed steroid-refractory CIP. We aimed to find risk factors of steroid-refractory CIP and evaluate the management strategies of immunomodulators (IMs).MethodsPatients with CIP were identified between August 2019 and August 2022 retrospectively. Clinical characteristics, peripheral blood biomarkers, and radiologic images were collected.ResultsAmong 1209 patients with solid tumor receiving programmed death (ligand)-1 antibody, 28 patients developed steroid-refractory CIP and 38 patients developed steroid-response CIP. Patients with steroid-refractory CIP had a higher proportion of previous interstitial lung disease (p=0.015) and grade 3–4 (p<0.001) at diagnosis. Otherwise, absolute neutrophil count (ANC), procalcitonin were higher and albumin was lower in steroid-refractory patients (ANC, p=0.009; procalcitonin, p=0.024; albumin, p=0.026). After multivariate analysis, grade 3–4 and higher ANC at diagnosis were confirmed to be independent risk factors for steroid-refractory CIP (grade, p=0.001; ANC, p=0.046). For grade 2 steroid-refractory CIP, additional IMs did not affect the prognosis (p=1.000). However, additional IMs reduced the risk of deterioration significantly in grade 3–4 steroid-refractory CIP (p=0.036).ConclusionsGrade 3–4 and higher peripheral blood ANC at diagnosis are associated with higher risk of steroid-refractory CIP. The use of additional IMs improves the outcome of grade 3–4 steroid-refractory CIP. These results can offer new insights to the decision-making of CIP management.
Systemic THrombolysis Randomization IN Endovascular Stroke Therapy (SHRINE) Collaboration: a patient-level pooled analysis of the SKIP and DEVT Trials
Authors: Nogueira Raul G , Kimura Kazumi , Matsumaru Yuji , Suzuki Kentaro , Qiu Zhongming , Zi Wenjie , Moran Timothy P , Li Fengli , Sang Hongfei , Luo Weidong , Liu Shuai , Yuan Junjie , Song Jiaxing , Huang Jiacheng , Takeuchi Masataka , Morimoto Masafumi , Otsuka Toshiaki , Yang Qingwu 
Published: June 2023

ObjectiveTo evaluate the non-inferiority of endovascular treatment (EVT) alone versus intravenous thrombolysis (IVT) followed by EVT and to assess its heterogeneity across prespecified subgroups.MethodsWe pooled data from two trials (SKIP in Japan; DEVT in China). Individual patient data were pooled to assess outcomes and heterogeneity of treatment effect. The primary outcome was functional independence (modified Rankin Scale score 0–2) at 90 days. Safety outcomes included symptomatic intracranial hemorrhage (sICH) and 90-day mortality.ResultsWe included 438 patients (217 EVT alone; 221 combined IVT+EVT). The meta-analysis failed to demonstrate the non-inferiority of EVT alone over combined IVT+EVT in achieving 90-day functional independence (56.7% vs 51.6%; adjusted common odds ratio (cOR)=1.27, 95% CI 0.84 to 1.92, pnon-inferiority=0.06). Effect sizes favoring EVT alone were present with stroke onset to puncture time longer than 180 min (cOR=2.28, 95% CI 1.18 to 4.38, pinteraction ≤180 vs >180 min=0.02) and intracranial internal carotid artery ICA occlusions (for ICA cOR=3.04, 95% CI 1.10 to 8.43, pinteraction ICA vs MCA=0.08). The rates of sICH (6.5% vs 9.0%; cOR=0.77, 95% CI 0.37 to 1.61) and 90-day mortality (12.9% vs 13.6%; cOR=1.05, 95% CI 0.58 to 1.89) were comparable.ConclusionsThe cumulative data of these two recent Asian trials failed to unequivocally demonstrate the non-inferiority of EVT alone over combined IVT+EVT. However, our study suggests a potential role for more individualized decision-making. Specifically, Asian patients with stroke onset to EVT longer than 180 min, as well as those with intracranial ICA occlusions and those with atrial fibrillation might have better outcomes with EVT alone than with combined IVT+EVT.