bluuebunny/crossref_metadata_2025_split huggingface dataset:
Real-Life Efficacy of Tofacitinib in Various Situations in Ulcerative Colitis: A Retrospective Worldwide Multicenter Collaborative Study
Authors: Resál Tamás , Bacsur Péter , Keresztes Csilla , Bálint Anita , Bor Renáta , Fábián Anna , Farkas Bernadett , Katsanos Kostas , Michalopoylos George , Ribaldone Davide Giuseppe , Attauabi Mohamed , Zhao Mirabella , Barak Hadar Amir , Yanai Henit , Bezzio Cristina , Rispo Antonio , Castiglione Fabiana , Bar-Gil Shitrit Ariella , Pugliese Daniela , Armuzzi Alessandro , Savarino Edoardo Vincenzo , Kolar Martin , Lukáš Milan , Chashkova Elena , Filip Rafał , Rozieres Aurore , Nancey Stéphane , Krznarić Željko , Schäfer Eszter , Szamosi Tamás , Sarlós Patrícia , Franko Matej , Drobne David , Knyazev Oleg V , Kagramanova Anna V , Limdi Jimmy , Wetwittayakhlang Panu , Lakatos Peter L , Maharshak Nitsan , Bannon Lian , Nyári Tibor , Szepes Zoltán , Farkas Klaudia ,   TFB Study Group, Saibeni Simone , Kastylova Kristyna , Seidelin Jakob Benedict , Burisch Johan , Hajdú Helga , Molnár Tamás 
Published: August 2023

Abstract

Background and Aims
Tofacitinib (TFB) appears to be effective in the treatment of ulcerative colitis (UC); however, available real-world studies are limited by cohort size. TFB could be an option in the treatment of acute severe ulcerative colitis (ASUC). We aimed to investigate efficacy and safety of TFB in moderate-to-severe colitis and ASUC.

Methods
This retrospective, international cohort study enrolling UC patients with ≥6-week follow-up period was conducted from February 1 to July 31, 2022. Indications were categorized as ASUC and chronic activity (CA). Baseline demographic and clinical data were obtained. Steroid-free remission (SFR), colectomy, and safety data were analyzed.

Results
A total of 391 UC patients (median age 38 [interquartile range, 28-47] years; follow-up period 26 [interquartile range, 14-52] weeks) were included. A total of 27.1% received TFB in ASUC. SFR rates were 23.7% (ASUC: 26.0%, CA: 22.8%) at week 12 and 41.1% (ASUC: 34.2%, CA: 43.5%) at week 52. The baseline partial Mayo score (odds ratio [OR], 0.850; P = .006) was negatively associated with week 12 SFR, while biologic-naïve patients (OR, 2.078; P = .04) more likely achieved week 52 SFR. The colectomy rate at week 52 was higher in ASUC group (17.6% vs 5.7%; P &lt; .001) and decreased with age (OR, 0.94; P = .013). A total of 67 adverse events were reported, and 17.9% resulted in cessation of TFB. One case of thromboembolic event was reported.

Conclusions
TFB is effective in both studied indications. TFB treatment resulted in high rates of SFR in the short and long terms. Higher baseline disease activity and previous biological therapies decreased efficacy. No new adverse event signals were found.
Ulcerative Colitis Is Associated With Diet-related Inflammation and Physical Activity in the IBD Partners E-cohort
Authors: DuBois Kelli E , Blake Christine E , Rudisill Caroline , Harrison Sayward E , Wirth Michael D , Hébert James R 
Published: August 2023

Abstract

Background
Individuals with ulcerative colitis (UC) seek complementary treatment methods, including diet and physical activity, to manage the burden of living with UC. This study examined associations between diet-associated inflammation, physical activity (PA), and UC-related health outcomes.

Methods
Data were obtained from 2052 IBD Partners e-cohort participants with UC. To quantify the inflammatory potential of food intake, dietary data were converted into Dietary Inflammatory Index (DII) and energy adjusted (E-DII) scores. Physical activity data were collected using the Godin-Shephard Leisure Time Activity Index. Outcome variables included the Simple Clinical Colitis Activity Index, Short Inflammatory Bowel Disease Questionnaire, and psychosocial PROMIS domains.

Results
Higher E-DII scores, as indicator of increased dietary inflammatory potential, were associated with increased disease activity (β = 0.166; P &lt; .001), anxiety (β = 0.342; P = .006), depression (β = 0.408; P = .004), fatigue (β = 0.386; P = .005), sleep disturbance (β = 0.339; P = .003), and decreased social satisfaction (β = -0.370; P = .004) and quality of life (β = −0.056; P &lt; .001). Physical activity was inversely associated with disease activity (β = −0.108; P &lt; .001), anxiety (β = −0.025; P = .001), depression (β = −0.025; P = .001), fatigue (β = −0.058; P &lt; .001), and sleep disturbance (β = −0.019; P = .008), while positively associated with social satisfaction (β = 0.063; P &lt; .001) and quality of life (β = 0.005; P &lt; .001). Beneficial effects were generally greater for strenuous PA intensity.

Conclusions
An anti-inflammatory diet and increased PA are associated with decreased disease activity, anxiety symptoms, depression symptoms, and fatigue, and associated with improved quality of life, sleep, and social satisfaction for patients with UC. Such modalities may reduce the daily burden of illness and aid in managing systemic and localized inflammation associated with UC.
Temperature and Turgor “Limitation” and Environmental “Control” in Xylem Biology and Dendrochronology
Authors: Segovia-Rivas Alí , Olson Mark E 
Published: August 2023

Synopsis
Trees and other woody plants are immensely ecologically important, making it essential to understand the causes of relationships between tree structure and function. To help these efforts, we highlight persistent traditions in plant biology of appealing to environmental factors “limiting” or “controlling” woody plant features. Examples include the idea that inevitable drops in cell turgor with plant height limit cell expansion and thus leaf size and tree height; that low temperatures prohibit lignification of cells and thus the growth of woody plants at high elevation; and notions from dendrochronology and related fields that climate factors such as rainfall and temperature “control” growth ring features. We show that notions of “control,” “limitation,” and the like imply that selection would favor a given trait value, but that these would-be favored values are developmentally impossible to produce. Such “limitation” scenarios predict trait frequency distributions that are very narrow and are abruptly curtailed at the upper limit of developmental possibility (the right-hand side of the distribution). Such distributions have, to our knowledge, never been observed, so we see little empirical support for “limitation” hypotheses. We suggest that, as a more productive starting point, plant biologists should examine adaptation hypotheses, in which developmental possibility is wide (congruent with the wide ranges of trait variation that really are observed), but only some of the possible variants are favored. We suggest that (1) the traditional the proximate/ultimate causation distinction, (2) purging scenarios of teleology/anthropomorphism, and (3) stating hypotheses in terms of developmental potential and natural selection are three simple ways of making “limitation” hypotheses clearer with regard to biological process and thus empirically testable.
Stress Hormone Dynamics Are Coupled to Brain Serotonin 4 Receptor Availability in Unmedicated Patients With Major Depressive Disorder: A NeuroPharm Study
Authors: Vulpius Gunild M , Köhler-Forsberg Kristin , Ozenne Brice , Larsen Søren V , Nasser Arafat , Svarer Claus , Gillings Nic , Keller Sune H , Jørgensen Martin B , Knudsen Gitte M , Frokjaer Vibe G 
Published: August 2023

Abstract

Background
A prominent finding in major depressive disorder (MDD) is distorted stress hormone dynamics, which is regulated by serotonergic brain signaling. An interesting feature of the cerebral serotonin system is the serotonin 4 receptor (5-HT4R), which is lower in depressed relative to healthy individuals and also has been highlighted as a promising novel antidepressant target. Here, we test the novel hypothesis that brain 5-HT4R availability in untreated patients with MDD is correlated with cortisol dynamics, indexed by the cortisol awakening response (CAR). Further, we evaluate if CAR changes with antidepressant treatment, including a selective serotonin reuptake inhibitor, and if pretreatment CAR can predict treatment outcome.

Methods
Sixty-six patients (76% women) with a moderate to severe depressive episode underwent positron emission tomography imaging with [11C]SB207145 for quantification of brain 5-HT4R binding using BPND as outcome. Serial home sampling of saliva in the first hour from awakening was performed to assess CAR before and after 8 weeks of antidepressant treatment. Treatment outcome was measured by change in Hamilton Depression Rating Scale 6 items.

Results
In the unmedicated depressed state, prefrontal and anterior cingulate cortices 5-HT4R binding was positively associated with CAR. CAR remained unaltered after 8 weeks of antidepressant treatment, and pretreatment CAR did not significantly predict treatment outcome.

Conclusions
Our findings highlight a link between serotonergic disturbances in MDD and cortisol dynamics, which likely is involved in disease and treatment mechanisms. Further, our data support 5-HT4R agonism as a promising precision target in patients with MDD and disturbed stress hormone dynamics.
Optimized Schwarz methods for the time-dependent Stokes–Darcy coupling
Authors: Discacciati Marco , Vanzan Tommaso 
Published: August 2023

Abstract
This paper derives optimized coefficients for optimized Schwarz iterations for the time-dependent Stokes–Darcy problem using an innovative strategy to solve a nonstandard min-max problem. The coefficients take into account both physical and discretization parameters that characterize the coupled problem, and they guarantee the robustness of the associated domain decomposition method. Numerical results validate the proposed approach in several test cases with physically relevant parameters.
Antibacterial activity of Lagerstreomia speciosa and its active compound, corosolic acid, enhances cefotaxime inhibitory activity against Staphylococcus aureus
Authors: Sinelius Sylvia , Lady Jullietta , Yunardy Michellina , Tjoa Enty , Nurcahyanti Agustina D R 
Published: August 2023

Abstract

Aims
Various epidemiology studies have reported the emergence of Staphylococcus aureus and its methicillin resistance strain causing global health concerns, especially during and post-COVID-19 pandemic. This pathogen presents as a co-infection in patients with COVID-19. In addition, certain virulence factors and resistance to β-lactam antibiotics, including cefotaxime, have been identified. We aimed to investigate the antibacterial activity of Lagerstreomia speciosa, a medicinal plant with antidiabetic activity, against S. aureus, including the strain resistant to methicillin. Furthermore, we examined whether the extract and one of its bioactive compounds, corosolic acid, can enhance the therapeutic effect of cefotaxime on antibiotic-resistant S. aureus.

Methods and results
The minimum inhibitory concentration of each substance was determined using the standard broth microdilution test following the checkerboard dilution. The type of interactions, synergistic, additivity, indifference, or antagonism, were determined using isobolograms analysis and the dose reduction index (DRI). The evaluation of synergy and bactericidal activity of the natural products in combination with cefotaxime was performed using the time-kill kinetic assay. Corosolic acid, L. speciosa leaves extract, and bark extract alone showed antibacterial activity against all tested S. aureus ATCC 33591, S. aureus ATCC 29213, S. aureus ATCC 25923, and clinical isolated S. aureus. Corosolic acid enhanced the antibacterial activity of cefotaxime, showing a synergistic effect and greater DRI of cefotaxime against all tested S. aureus strains. Time-kill kinetic assay showed that corosolic acid has a more profound effect than L. speciosa extracts to potentiate the bactericidal activity of cefotaxime. Whereas L. speciosa leaves and bark extract showed some inhibitory effect on the growth of S. aureus after a single administration.

Conclusions
Lagerstreomia speciosa leaves and bark extract and its active compound, corosolic acid, could be used as a potential anti-Staphylococcus aureus treatment to enhance the therapeutic use of cefotaxime.
Utilization of electronic health records and associated factors among nurses in a faith-based teaching hospital, Ilishan, Nigeria
Authors: Ayamolowo Love B , Irinoye Omolola O , Olaniyan Abayomi S 
Published: August 2023

AbstractIntroductionIt has been documented that nurses’ use of electronic health records (EHRs) impacts clients’ health outcomes positively. Some health facilities, primarily privately owned institutions, introduced EHRs for optimal healthcare. Evidence of such and associated factors among nurses must be documented to improve utilization and quality.ObjectiveThe study assessed the utilization of EHRs and associated factors among nurses in a faith-based teaching hospital.Materials and MethodsThis sequential explanatory mixed-methods study involved a sample of all 240 nurses from a teaching hospital where EHRs have been introduced. Quantitative data through semistructured questionnaires were collected and analyzed using Chi-square and logistic regression. Qualitative data were collected from 10 purposively selected nurses using an in-depth interview guide and analyzed through content analysis.ResultsThe majority of participants reported availability of EHR computer software (62.8%), internet facility (84.2%), and desktops (76.3%), but EHR was poorly utilized (27.3%). Factors significantly associated were nurses who were females [OR (odds ratio) = 1.5, 95% CI (confidence interval), 0.21–11.24], BNSc degrees holders [OR = 4.3; 95% CI, 1.06–17.43]; had computer EHR software [OR = 7.4, 95% CI, 0.83–3.81], and sponsored EHR training [OR = 2.10; 95% CI, 0.24–18.6]. Noncapturing of nursing tasks and nursing standardized language by EHR software, lack of institutional enforcement on EHR use, and absence of clear EHR policies were the main identified themes for the key barriers to using EHRs.ConclusionEHR was poorly utilized among nurses. Gender, educational qualification, EHR resources, and sponsored training were factors significantly associated with the use. There is an urgent need for comprehensive EHR packages, sustained sponsored training, and formulation of EHR policy for effective EHR implementation.
Removing maternal heat stress abatement during gestation modulated postnatal physiology and improved performance of Bos indicus-influenced beef offspring
Authors: Izquierdo Vinicius S , Silva João V L , Ranches Juliana , Santos Giovanna C M , Carroll Jeffery A , Burdick Sanchez Nicole C , Bittar João H J , Vendramini João M B , Moriel Philipe 
Published: August 2023

Abstract
This study evaluated the growth and immune response of beef calves born from Bos indicus-influenced beef heifers provided pre- and postpartum heat abatement on pasture. On 83 ± 4 d prepartum (day 0), 64 Brangus crossbred beef heifers (~¼ B. indicus) were stratified by body weight (BW; 454 ± 37 kg) and body condition score (BCS; 6.3 ± 0.28; scale 1 to 9), and then allocated into 1 of 16 bahiagrass pastures (1 ha and 4 heifers per pasture). Treatments were randomly assigned to pastures (8 pastures per treatment) and consisted of heifers provided (SH) or not (NSH) access to artificial shade (4.5 m2 of shade area per heifer) from 83 d prepartum to 50 d postpartum (days 0 to 133). Heifers and calves were managed similarly from day 133 until the start of the breeding season (day 203). Calves were weaned on day 203 (at 119 ± 19 d of age), limit-fed the same drylot diet at 3.5% of BW (DM basis) days 209 to 268 (3 to 4 calves per pen; 8 pens per treatment) and vaccinated against respiratory disease pathogens on days 222 and 236. Heifer intravaginal temperatures from days 35 to 42 were lower (P ≤ 0.03) for NSH vs. SH heifers from 0000 to 0800 hours but greater (P ≤ 0.05) for NSH vs. SH heifers from 1100 to 1800 hours. Heifer intravaginal temperature from days 126 to 132 did not differ (P = 0.99) between NSH and SH heifers. Heifers assigned to NSH had greater respiration rates from days 20 to 96 (P ≤ 0.0007), greater plasma concentration of cortisol on days 35 (P = 0.07) and 55 (P = 0.02), less plasma concentration of insulin-like growth factor 1 (IGF-1) on days 35 (P = 0.10), 55, and 133 (P ≤ 0.05), and less BCS from days 55 to 203 (P ≤ 0.01) compared to SH heifers. Calves born from NSH heifers had less birth BW (P = 0.05), greater overall plasma haptoglobin concentrations (P = 0.05), greater seroconversion against bovine respiratory syncytial virus on day 222 (P = 0.02), tended to have greater ADG from days 209 to 268 (P = 0.07), and had greater BW on day 268 (P = 0.05) compared to SH offspring. Plasma concentrations of cortisol and serum titers against other respiratory disease pathogens did not differ (P ≥ 0.15) between NSH and SH offspring. Hence, removing maternal access to artificial shade: (1) increased prepartum intravaginal temperature and plasma concentrations of cortisol but reduced prepartum BCS and plasma concentrations of IGF-1 in grazing B. indicus-influenced beef heifers; and (2) increased post-weaning BW gain and had positive effects on humoral immune response of their offspring.
A diagnosis method for imbalanced bearing data based on improved SMOTE model combined with CNN-AM
Authors: Wang Zhenya , Liu Tao , Wu Xing , Liu Chang 
Published: August 2023

Abstract
A boundary enhancement and Gaussian mixture model (G) optimized synthetic minority oversampling technique (SMOTE) algorithm (BE-G-SMOTE) is proposed to improve diagnostic accuracy under imbalanced bearing fault data conditions. It is designed to solve the problem that the diversity of samples generated by the original SMOTE model is limited, as well as the deep learning model is limited by the size of training samples and processing speed. Firstly, a few bearing fault data are clustered by G to achieve cluster division. Secondly, according to the cluster density distribution function designed in this paper, the weights of different clusters and sample weights to achieve intra-class balance are determined and data quality is improved. Then, to take full advantage of the limited fault data, based on the sensitivity of the support vector machine (SVM) to imbalanced data, the enhanced boundary is established between generated data and the SVM classifier under different penalty factor (PF) values. According to the accuracy, the optimal PF is determined, and fault datasets satisfying diversity are obtained. To improve the classification accuracy, a convolutional neural network with an attention mechanism is built. Finally, analysis using two practical cases shows the effectiveness of the proposed method.
Delivering ADAPT+ to Latino Families Living in Rural Communities: Feasibility and Acceptability of Implementing a Health Promotion Program Including Mindfulness
Authors: Stern Marilyn , Rancourt Diana , Soca Lozano Sandra , Buro Acadia W , Gray Heewon L , Rodriguez Carmen , Bailey Rocio , Redwine Laura 
Published: August 2023

Abstract

Background
Obesity is a major public health crisis in Latino youth. Mounting evidence implicates stress in the development and maintenance of obesity. This study examined the feasibility and acceptability of having community health workers, i.e., promotoras, deliver Adaptando Dieta y Acción Para Todos (ADAPT)+, a family-based health promotion program integrating mindfulness strategies for stress reduction to underserved Latino families in rural communities.

Methods
In an ORBIT model Phase IIb longitudinal quasi-cluster feasibility study, promotoras delivered the 6-session ADAPT+ intervention and 1-session Enhanced Usual Care (EUC) in rural Florida. Feasibility was assessed via sample size and recruitment, randomization by community, data collection completion, and intervention fidelity. Acceptability was assessed via participant retention and program satisfaction. Effect sizes of differences in parent stress and mindful eating between conditions at baseline, end of treatment, and 3-month follow-up were calculated.

Results
Feasibility and acceptability were demonstrated. The recruitment target was 99% met (n = 95 recruited). Randomization was limited to site level due to coronavirus disease 2019-related challenges. Data collection procedures were feasible (100% completion). Retention was 86% at post-assessment and 82.6% at 3-month follow-up. All sessions were completed (100% fidelity). Mean program satisfaction was 3.91/4.00. ADAPT+ parents reported lower stress (difference = −3.04, medium-to-large effect, d = .70) and more mindful eating (difference = 2.00, medium effect, d = .44) than EUC parents at 3-month follow-up.

Conclusion
Study implementation and intervention delivery to rural Latino families using promotoras were feasible and acceptable. Promising findings regarding parent stress and mindful eating support a larger (ORBIT Phase III) efficacy trial.

Clinical Trial Registration
This trial was registered with ClinicalTrials.gov under identifier NCT04800432.
Exploration of the candidate beneficial bacteria for Penaeus vannamei culture by core microbiome analysis using amplicon sequencing
Authors: Lalitha Natarajan , Ronald Berty Samuel Masilamoni , Chitra Murugesan Ananda , Jangam Ashok Kumar , Katneni Vinaya Kumar , Suganya Panjan Nathamuni , Senthilnayagam Hemalatha , Senthilkumar Tuticorin Maragatham Alagesan , Muralidhar Moturi 
Published: August 2023

Abstract
Globally, Penaeus vannamei is the vital species in aquaculture production. Beneficial bacterial exploration of gut, sediment, and water were investigated in P. vannamei culture using Illumina Miseq sequencing of 16S RNA V3-V4 hypervariable regions. Predominant phyla identified were Proteobacteria, Tenericutes, Bacteroidetes in gut; Proteobacteria, Bacteroidetes, Planctomycetes in sediment and Cyanobacteria, Proteobacteria, and Planctomycetes in water. In total, 46 phyla, 509 families and 902 genera; 70 phyla, 735 families and 1255 genera; 55 phyla, 580 families and 996 genera were observed in gut, sediment and water, respectively. Diversity of microbial communities in respect of observed Operational Taxonomic Units, diversity indices (Shannon and Simpson), richness index (Chao1) were significantly high P (&lt;0.05) in 60 DoC in gut and 30 DoC in sediment. Beta diversity indicated separate clusters for bacterial communities in gut, sediment and water samples and formation of distinct community profiles. Core microbiome in P. vannamei rearing ponds over a time consisted of 9, 21, and 20 OTUs in gut, rearing water and sediment, respectively. This study helps to intervene with suitable beneficial microbes to establish an aquaculture system thereby contributes to enhance the productivity, improve water quality and pond bottom condition, and control the pathogenic agents at each stage of the culture.
The Yijing Principles in the Japanese Creation Myth: A Study of the Jindai-No-Maki (‘Chapters on the Age of the Gods’) in the Nihon Shoki (‘The Chronicles Of Japan’)
Authors: Ng Benjamin Wai-ming 
Published: August 2023

Abstract
The Yijing (‘Classic of Changes’) is an important text in Daoist and Confucian traditions in China. It also served as a building block of ancient Japanese culture. The Japanese creation myth described in the Jindai no maki (‘Chapters on the Age of the Gods’) of the Nihon shoki (‘Chronicles of Japan’, 720 CE) was strongly influenced by such Yijing-related concepts as taiji (‘Supreme Ultimate’), yinyang (the two complementary and contradictory forces in the universe), qiankun (first two trigrams representing heaven and earth), sancai (three powers or realms of the universe: heaven, earth, man), wuxing (five phases or agents), and bagua (eight trigrams). The Japanese creation myth was later Confucianised in the Tokugawa period (1603–1868), when Japanese Confucian and Shinto scholars provided the Neo-Confucian metaphysical underpinning for Shinto mythology. Based on a close reading of the Jindai no maki, this study aims to investigate how Yijing-related concepts were used to construct the Japanese creation myth and how Tokugawa Confucian and Shinto scholars further elaborated upon it.