bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparing the Mental Health of Healthcare Students: Mental Health Shame and Self-compassion in Counselling, Occupational Therapy, Nursing and Social Work Students
Authors: Kotera Yasuhiro , Jackson Jessica E. , Kirkman Ann , Edwards Ann-Marie , Colman Rory , Underhill Ann , Jackson Jessica G. , Baker Denise , Ozaki Akihiko 
Published: February 2023

AbstractPoor mental health of healthcare students is a cause for concern in many universities. Though previous research has identified mental health shame and self-compassion as critical in this student group, how these variables differ across different healthcare disciplines remains to be evaluated. Healthcare students (n = 344; counselling, occupational therapy, social work and nursing) completed measures regarding these variables. MANOVA and regression analyses were performed. (1) Counselling and nursing students were more depressed than occupational therapy students; (2) nursing students were more anxious than occupational therapy and social work students; (3) occupational therapy students had more positive attitudes towards mental health than the others; and (4) nursing students worried about their own reputation associated with their family more than counselling students. Self-compassion was the strongest predictor of mental health in all groups; however, the effect sizes varied: largest in nursing and smallest in social work students. Findings will help inform effective interventions for students in each healthcare discipline.
PCSK9 Inhibition Reduces Depressive like Behavior in CUMS-Exposed Rats: Highlights on HMGB1/RAGE/TLR4 Pathway, NLRP3 Inflammasome Complex and IDO-1
Authors: Hendawy Nevien , Salaheldin Tala H. , Abuelezz Sally A. 
Published: February 2023

AbstractAmple evidence has pointed to a close link between cardiovascular diseases (CVD) and depression. Inflammatory pathways including the high-mobility-group-box-1 protein, receptor-for-advanced-glycation-end-products and toll-like-receptor-4 (HMGB1/RAGE/TLR4) and nucleotide-binding domain (NOD)–like receptor protein 3 (NLRP3) inflammasome pathways are thought to be crucial players in this link. Activation of these pathways ends by releasing of different inflammatory mediators involved in CVD and depression pathophysiology. In the brain, this inflammatory process enhanced indoleamine2,3-dioxygenase-1 (IDO-1) activation with subsequent alteration in kynurenine/tryptophan levels causing depression. Based on the favorable anti-inflammatory effects of Alirocumab, the proprotein-convertase-subtilisin/kexin-type-9 (PCSK9) inhibitor, used in different CVD, this study was designed to investigate its potential antidepressant effect. The behavioral and neurochemical effects of concomitant treatment of Alirocumab at doses of (4, 8 and 16 mg/kg/week subcutaneously) in Wistar rats exposed to chronic unpredictable mild stress (CUMS) for 6 weeks were assayed. Alirocumab prevented CUMS-induced depressive-like-behaviors exhibited in open-field and forced-swimming tests, and hypothalamus–pituitary–adrenal axis hyperactivity (adrenal gland weight and serum corticosterone). Alirocumab prevented CUMS-induced alteration in hippocampal kynurenine/tryptophan levels and pro-inflammatory cytokines tumor-necrosis-factor-alpha, interleukin-1beta (IL-1β), IL-2 and IL-6. Western blot and PCR analysis showed that Alirocumab favorably modulated the HMGB1/RAGE/TLR4 axis, nuclear-factor-kappa-beta, NLRP3 inflammasome complex and IDO-1 in the hippocampus of CUMS rats. These effects were correlated to the level of PCSK9 expression. The behavioral and biochemical findings indicated the potential antidepressant effect of PCSK9 inhibition by Alirocumab.
Graphical Abstract
EndoTrainer: a novel hybrid training platform for endoscopic surgery
Authors: Hernansanz Albert , Rovira Ramon , Basomba Joan , Comas Roger , Casals Alícia 
Published: February 2023

Abstract
Purpose
Endoscopy implies high demanding procedures, and their practice requires structured formation curricula supported by adequate training platforms. Physical platforms are the most standardised solution for surgical training, but over the last few years, virtual platforms have been progressively introduced. This research work presents a new hybrid, physic-virtual, endoscopic training platform that exploits the benefits of the two kind of platforms combining realistic tools and phantoms together with the capacity of measuring all relevant parameters along the execution of the exercises and of providing an objective assessment performance.

Methods
The developed platform, EndoTrainer, has been designed to train and assess surgical skills in hysteroscopy and cystoscopy following a structured curricula. The initial development and validation is focused on hysteroscopic exercises proposed in the Gynaecological Endoscopic Surgical Education and Assessment (GESEA) Certification Programme from The Academy and European Society for Gynaecological Endoscopy (ESGE) and analyses the obtained results of an extensive study with 80 gynaecologists executing 30 trials of the standard 30 degree endoscope navigation exercise.

Results
The experiments demonstrate the benefits of the presented hybrid platform. Multi-variable statistical analysis points out that all subjects have obtained statistically significant improvement in all relevant parameters: shorter and safer trajectories, improved 30-degree endoscope navigation, accurate positioning over the targets and reduction of the execution time.

Conclusion
This paper presents a new hybrid approach for training, and evaluating whether it provides an objectivable improvement of camera navigation endoscopic basic skills. The obtained results demonstrate the initial hypothesis: all subjects have improved their camera handling and navigation skills.
Diversitäts- und kultursensible Gesundheitsinformationen für mehr digitale Gesundheitskompetenz: Eine kollaborative Community-Forschung zu Barrieren und Bedarfen
Authors: Geldermann Anna , Falge Christiane , Betscher Silke , Jünger Saskia , Bertram Caren , Woopen Christiane 
Published: February 2023

Zusammenfassung
Hintergrund
Bei Gesundheitsfragen spielt das Internet eine zentrale Rolle, wobei Verbraucher:innen vor der Herausforderung stehen, geeignete Such- und Bewertungsstrategien zu entwickeln. Damit Informationen zur Gesundheit im Internet gefunden, verstanden, beurteilt und angewendet werden können, bedarf es digitaler Gesundheitskompetenz auf individueller und auf organisationaler Ebene. Vor dem Hintergrund gesellschaftlicher Pluralität und Diversität wurden Fähigkeiten und Zugänge marginalisierter Communities in diesem Zusammenhang bisher wenig beforscht.

Ziel
Diese Studie untersuchte die Nutzung von Online-Gesundheitsinformationen im Alltag aus einer postmigrantischen Perspektive, welche nicht Migrationshintergründe, sondern lokale Kontexte von Migrant:innen in Deutschland als Vulnerabilitätsvariable versteht. Ziel dieser Studie war es, sowohl das digitale Gesundheitsinformationsverhalten marginalisierter Communities ethnografisch und kollaborativ zu erforschen als auch praxisnahe und kultursensible Ansätze für Akteur:innen der Gesundheitskommunikation zu entwickeln ohne migrantisierende Zuschreibungen zu reproduzieren.

Methoden
Im Rahmen einer kollaborativen ethnografischen Feldforschung im Stadtteillabor der Bochumer Hustadt von 10/2020–01/2021 führten Community-Forscher:innen online leitfadengestützte Interviews in ihrem Umfeld durch. Die Interviews wurden mittels einer qualitativen Inhaltsanalyse ausgewertet.

Ergebnisse und Diskussion
Die Ergebnisse machen deutlich, dass sprachliche, inhaltliche und mediale Aspekte von Online-Gesundheitsinformationen den Zugang zu und Umgang mit diesen für marginalisierte Communities bedingen. Die postmigrantische Perspektive stellt einerseits Migration als hinreichende Analyse- und Erklärungskategorie in Frage und begründet zugleich Diversitäts- und Kultursensibilität als zentrale Komponenten des Zugangs zu Gesundheitsinformationen und der Entwicklung von Maßnahmen zur Stärkung der digitalen Gesundheitskompetenz in pluralen Gesellschaften. Es bedarf sowohl vielsprachiger, transkulturell resonierender und technisch barrierearmer Online-Gesundheitsinformationen als auch gestärkter Interaktion zwischen Individuen einer pluralen postmigrantischen Gesellschaft und der Online-Gesundheitskommunikation.
Users’ perception for innovation and sustainability management: evidence from public transport
Authors: Gómez-Ortega Alba , Flores-Ureba Sandra , Gelashvili Vera , Jalón María Luisa Delgado 
Published: February 2023

AbstractNo one doubts the importance of public transport services in the economic backbone of any country. In recent decades, there has been a growing interest in the contribution to Sustainable Development Goals on the part of governments, companies, and stakeholders. In this sense, transport can contribute to the sustainability of cities and facilitate other social objectives, such as universal accessibility, with innovation being a key pillar for this. Thus, the main objective of this study is to analyze users’ perceptions of the innovation and sustainability of public transport in Spain.To analyze the user’s perception of public transport, a questionnaire was developed following Bitner’s Servicescape Model. A total of 1,354 responses were collected in different Spanish cities. The main results show that the policies implemented in both innovation and sustainability are perceived positively but do not seem to have much impact on the service user. Public transport users prioritize the speed, frequency, and safety of the service received. In addition, it should be noted that the gender of the user influences the preferences of the objectives, i.e., men value technological development in public transport more. At the same time, women give higher priority to sustainability. The age of users is another variable that conditions public transport users’ perceptions of innovation and sustainability. The results also show users’ preferences for different types of public transport.The study’s main contribution is that it shows to what extent the innovation and sustainability policies applied in the public transport service are valued and motivate citizens to use the service. The political and management decisions may be disconnected from the reality perceived by users. These decisions may be more linked to regulatory pressures and involve a high implementation cost, so it is necessary to consider the valuation of users’ service so that the benefit or social return of these investments is high, encouraging the use of the service.
Paraneoplastic Neurologic Disorders
Authors: Gilligan Michael , McGuigan Christopher , McKeon Andrew 
Published: February 2023

Abstract
Purpose of Review
To provide an overview and highlight recent updates in the field of paraneoplastic neurologic disorders.

Recent Findings
The prevalence of paraneoplastic neurologic disorders is greater than previously reported and the incidence has been rising over time, due to improved recognition in the era of antibody biomarkers. Updated diagnostic criteria that are broadly inclusive and also contain diagnostic risk for clinical presentations (high and intermediate) and diagnostic antibodies (high, intermediate, and low) have replaced the original 2004 criteria. Antibody biomarkers continue to be characterized (e.g., KLHL-11 associated with seminoma in men with brainstem encephalitis). Some paraneoplastic antibodies also provide insight into likely immunotherapy response and prognosis. The rise of immune checkpoint inhibitors as cancer therapeutics has been associated with newly observed immune-mediated adverse effects including paraneoplastic neurological disorders. The therapeutic approach to paraneoplastic neurologic disorders is centered around cancer care and trials of immune therapy.

Summary
The field of paraneoplastic neurologic disorders continues to be advanced by the identification of novel antibody biomarkers which have diagnostic utility, and give insight into likely treatment responses and outcomes.
Optimization of mechanical properties of bamboo fiber reinforced epoxy hybrid nano composites by response surface methodology
Authors: Kumar Roopesh , Ganguly Abhijeet , Purohit Rajesh 
Published: February 2023

AbstractAt present, materials obtained from nature are adopted with high priority due to exploitation of natural resources ofthe materials. This work is focused on the use of natural fibre with nano-silica as reinforcement in epoxy resin as a matrix. The polymer composites were developed by mixing an appropriate amount of nano SiO2 with bamboo fibres. After composite fabrication, specimens of standard size were prepared, and tests related to mechanical properties were performed. 32H compositesperformed best in the tensile test. The flexural test value for 32G composite was the highest. We found that the 32H composite had better energy absorption capacity. Response surface methodology (RSM) was used to find the optimum composition of composites, and the effects of fibre and nano-SiO2 on their mechanical properties were investigated. A central composite design was employed to analyse the composite properties. A second order polynomial model was used for predicting strength of the composites. It has been found that the composite was best fit by a quadratic regression model with an excessive co-efficient to determine the R2 value. Effects of bamboo fibre and nano-SiO2 were examined using analysis of variance (ANOVA).Experiment found that two-layer natural bamboo fibre with 2 wt.% of silica is of high quality. Nano composites of fabricated natural fibre reinforced polymer has numerous uses in automotive, aircraft, aerospace, sporting, structural, and home appliance industries.
Cerebellum Lecture: the Cerebellar Nuclei—Core of the Cerebellum
Authors: Kebschull Justus M. , Casoni Filippo , Consalez G. Giacomo , Goldowitz Daniel , Hawkes Richard , Ruigrok Tom J. H. , Schilling Karl , Wingate Richard , Wu Joshua , Yeung Joanna , Uusisaari Marylka Yoe 
Published: February 2023

AbstractThe cerebellum is a key player in many brain functions and a major topic of neuroscience research. However, the cerebellar nuclei (CN), the main output structures of the cerebellum, are often overlooked. This neglect is because research on the cerebellum typically focuses on the cortex and tends to treat the CN as relatively simple output nuclei conveying an inverted signal from the cerebellar cortex to the rest of the brain. In this review, by adopting a nucleocentric perspective we aim to rectify this impression. First, we describe CN anatomy and modularity and comprehensively integrate CN architecture with its highly organized but complex afferent and efferent connectivity. This is followed by a novel classification of the specific neuronal classes the CN comprise and speculate on the implications of CN structure and physiology for our understanding of adult cerebellar function. Based on this thorough review of the adult literature we provide a comprehensive overview of CN embryonic development and, by comparing cerebellar structures in various chordate clades, propose an interpretation of CN evolution. Despite their critical importance in cerebellar function, from a clinical perspective intriguingly few, if any, neurological disorders appear to primarily affect the CN. To highlight this curious anomaly, and encourage future nucleocentric interpretations, we build on our review to provide a brief overview of the various syndromes in which the CN are currently implicated. Finally, we summarize the specific perspectives that a nucleocentric view of the cerebellum brings, move major outstanding issues in CN biology to the limelight, and provide a roadmap to the key questions that need to be answered in order to create a comprehensive integrated model of CN structure, function, development, and evolution.
Trajectories of oxygen saturation within 6–72 hours after birth in neonates at moderate altitude: a prospective longitudinal cohort study
Authors: Zhao Qu-Ming , Chen Hong-Yan , Li Shi-Xiu , Yan Wei-Li , Hu Xiao-Jing , Huang Guo-Ying 
Published: February 2023

Abstract
Background
Trajectories of pulse oxygen saturation (SpO2) within the first few days after birth are important to inform the strategy for identifying asymptomatic hypoxemic disease but remain poorly substantiated at higher altitudes.

Methods
We performed a longitudinal cohort study with consecutive neonates at a local hospital in Luchun County, China, at an altitude of 1650 m between January and July 2020. We repeatedly measured the pre- and post-ductal SpO2 values at 6, 12, 18, 24, 36, 48, and 72 hours after birth for neonates without oxygen supplements. All neonates underwent echocardiography and were followed up to 42 days after discharge. We included neonates without hypoxemic diseases to characterize the trajectories of SpO2 over time using a linear mixed model. We considered the 2.5th percentile as the reference value to define hypoxemic conditions.

Results
A total of 1061 neonates were enrolled. Twenty-five had non-cardiac hypoxemic diseases, with 84% (21/25) presenting with abnormal SpO2 within 24 hours. One had tetralogy of Fallot identified by echocardiography. Among the 1035 asymptomatic neonates, SpO2 values declined from 6 hours after birth, reached a nadir at 48 hours, and tended to level off thereafter, with identical patterns for both pre- and post-ductal SpO2. The reference percentile was 92% for both pre- and post-ductal SpO2 and was time independent.

Conclusions
A decline within 48 hours features SpO2 trajectories within the first 72 hours at moderate altitude. Our findings suggest that earlier screening may favorably achieve a benefit–risk balance in identifying asymptomatic hypoxemic diseases in this population.
A theory of predictive sales analytics adoption
Authors: Habel Johannes , Alavi Sascha , Heinitz Nicolas 
Published: February 2023

Abstract
Given the pervasive ubiquity of data, sales practice is moving rapidly into an era of predictive analytics, using quantitative methods, including machine learning algorithms, to reveal unknown information, such as customers’ personality, value, or churn probabilities. However, many sales organizations face difficulties when implementing predictive analytics applications. This article elucidates these difficulties by developing the PSAA model—a conceptual framework that explains how predictive sales analytics (PSA) applications support sales employees’ job performance. In particular, the PSAA model conceptualizes the key contingencies governing how the availability of PSA applications translates into adoption of these applications and, ultimately, job performance. These contingencies determine the extent to which sales employees adopt these applications to revise their decision-making and the extent to which these updates improve the decision outcome. To build the PSAA model, we integrate literature on predictive analytics and machine learning, technology adoption, and marketing capabilities. In doing so, this research provides a theoretical frame for future studies on salesperson adoption and effective utilization of PSA.
Career change teachers in hard-to-staff schools: should I stay or leave?
Authors: Dadvand Babak , van Driel Jan , Speldewinde Chris , Dawborn-Gundlach Merryn 
Published: February 2023

AbstractRecruiting career changers into teaching has emerged as a part of a strategy by governments worldwide to address complex teacher shortage problems in hard-to-staff schools. In this paper, we present a case study of two career change teachers and trace their career journey into Initial Teacher Education (ITE) and the teaching profession in two separate hard-to-staff schools. We interviewed these teachers during the first 2 years of their career change journey. During this period, ‘push-and-pull’ factors impacted their intentions to stay in the profession. Challenges included inadequate school-level mentorship support, social-geographic isolation in a regional school setting during the COVID-19 remote learning and the more complex working conditions in hard-to-staff schools. The adverse impacts of these challenges were, to some extent, mitigated by the participants’ commitment to making a positive difference in the lives of children and young people through the teaching profession, a strong work ethic and support provided by their ITE programme in the form of university-based mentors and adjustment to study requirements. The participants responded to these push-and-pull factors in ways that highlighted their reflexive decision-making and determination to stay in teaching despite challenges. We discuss the implications of these findings for workforce planning strategies aimed at recruiting career change teachers in hard-to-staff schools.
Minus-C subfamily has diverged from Classic odorant-binding proteins in honeybees
Authors: Mam Bhavika , Karpe Snehal D. , Sowdhamini Ramanathan 
Published: February 2023

AbstractOdorant-binding proteins (OBPs) in insects bind to volatile chemical cues that are important in regulating insect behavior. It is hypothesized that OBPs bind with specificity to certain volatiles and may help in transport and delivery to odorant receptors (ORs), and may help in buffering the olfactory response and aid the insect in various behaviors. Honeybees are eusocial insects that perceive olfactory cues and strongly rely on them to perform complex olfactory behaviors. Here, we have identified and annotated odorant-binding proteins and few chemosensory proteins from the genome of the dwarf honey bee, Apis florea, using an exhaustive homology-based bioinformatic pipeline and analyzed the evolutionary relationships between the OBP subfamilies. Our study confirms that the Minus-C subfamily in honey bees has diverged from the Classic subfamily of odorant-binding proteins.
Fenton-like photocatalyzed degradation of dibutyl phthalate with goethite and carboxylic acids
Authors: Hejda S. , Buzek D. , Kluson P. , Bajt O. 
Published: February 2023

AbstractDetailed investigation of photocatalyzed degradation of dibutyl phthalate (DBP), an endocrine disrupter, in the presence of α-FeOOH (goethite) and different carboxylic acids is the focus of this study. To get a better insight into the efficiency of the degradation, the influence of different parameters, such as concentration of total Fe and Fe(II), dissolved oxygen, DBP concentration, pH and salinity is investigated. The reaction mechanism consists of several interrelationship steps. The first step is the chemical reaction of carboxylic acid groups of the organic acids with hydroxyl groups of the α-FeOOH and a charge transfer upon illumination generating Fe(II). The second step is the release of Fe(II) into the solution followed by H2O2 oxidation to form highly photoactive hydroxyl complex of iron(III) and ˙OH. Simultaneously, the superoxide radical O2˙− and hydroperoxyl radical is formed in acidic solutions in presence of carboxylic acids as well. This mechanism explains the genesis of different reactive species oxidizing DBP. From the variety of the studied carboxylic acids (oxalic, citric, salicylic, pyruvic, maleic, and fumaric), oxalic acid is the best Fe-ligand for the photoreductive dissolution of goethite. Concentrations of the total amount of Fe and its dissociated forms Fe(II) as well as oxygen and hydroxyl radicals play a fundamental role in efficiency of DBP degradation. The photodegradation of DBP with goethite and the use of suitable carboxylic acids under optimized reaction conditions could be an efficient process for decontamination of polluted waters.