bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interaction of circular cavity and crack near anisotropic bi-material interface under SH-waves incidence
Authors: Zhang Jian-wei , Lan Guo-guan , Chen Shui-mei , Xu Hua-nan , Yang Zai-lin 
Published: January 2023

AbstractAn anisotropic bi-material interface with a circular hollow and a crack was used to explore the scattering of SH waves using complex variables and Green's function techniques. A horizontal interface in a bi-material media forms an elastic anisotropic half-space with a circular cavity and a linear crack, whereas the other half-space is an elastic isotropic half-space. The Green's function approach is used to derive the relevant Green's functions, which are then used in the “crack division” procedure to create a crack. During the joining of the two pieces, unknown anti-plane forces are applied to the horizontal surfaces to ensure the interface maintains its continuity criteria. For weakly singular integral equations, Fredholm integral equations are inferred and solved using the direct discrete technique. The simulation results were represented graphically to show how different parameters affect the influence of dynamic stress concentration factors around the cavity and dynamic stress intensity factors toward the crack tip. For example, a cavity's wave number and angle of incidence, as well as the distance between the cavity's center and its horizontal interface and its radius, are all elements that must be taken into consideration.
Hirst on rational moral education
Authors: Hand Michael 
Published: January 2023

AbstractIn Moral Education in a Secular Society, Paul Hirst offers accounts of the content and justification of morality and the aims and methods of moral education. My own recent book, A Theory of Moral Education, does the same. Here I explore the similarities and differences between our theories. In the first part of the paper, I outline what Hirst calls the ‘sophisticated view of education’, which I wholeheartedly endorse, and highlight his attention to the noncognitive as well as the cognitive aspects of morality. In the second part, I explain how Hirst’s transcendental justification of morality differs from my contractarian justification and trace the implications of this difference for our respective accounts of moral education.
Paul Hirst, education and epistemic injustice
Authors: Marabini Alessia 
Published: January 2023

AbstractIn this paper I individuate and analyse a new type of epistemic injustice that can arise in education and depends on the so-called ‘backtracking fallacy’ in student assessment, which occurs when a teacher confuses (or does not distinguish between) the logical dimension of a framework of disciplinary concepts and its psychological dimension. I will also touch upon a different type of social injustice that might transpire in education. I suggest that familiarity with Paul Hirst's view of liberal education, which presupposes a neat distinction between public framework of knowledge and the psychological process of gradually learning it, can contribute to prevent or reduce both forms of injustice.
Education since 2010: Hirstian echoes
Authors: White John 
Published: January 2023

Abstract
Although Paul Hirst was no longer working in the educational field between 2010 and 2020, echoes of his ideas resonate through the decade. I look at three examples. [1] The National Curriculum. In the 1990s Hirst had been critical of the newly introduced National Curriculum of 1988, built as it was around ten foundation subjects rather than practices of everyday life. While curricular reforms under the Labour governments of 1997–2010 came somewhat closer to his ideas, there has been a reversion since then to a subject-centred curriculum, with tests and examinations based on it much to the fore. But calls for more attention to social issues like climate change and ethnic diversity have Hirstian resonances, as have critical comments on the status quo from leading figures in politics and the inspectorate. [2] ‘Powerful knowledge.’ This notion, closely associated with the sociologist Michael Young, has been widely influential in educational circles since 2010. Its original definition in terms of bodies of knowledge with their own systems of concepts, is reminiscent of Hirst's celebrated and later abandoned ‘forms of knowledge’ theory. The paper speculates on possible biographical explanations of this commonality. [3] Teacher education. In 2017 HMCI Amanda Spielman commented on the need to improve teachers’ poor understanding of curriculum theory and notes that in the past it was better. This chimes with comments of Paul Hirst in 1994, although it is not clear how far Spielman would support his view that this work should first be rooted in practical teaching experience.
Nutritional benefits, ethnomedicinal uses, phytochemistry, pharmacological properties and toxicity of Spondias mombin Linn: a comprehensive review
Authors: Ogunro Olalekan Bukunmi , Oyeyinka Barnabas Oluwatomide , Gyebi Gideon Ampoma , Batiha Gaber El-Saber 
Published: January 2023

Abstract

Objectives
Spondias mombin is traditionally used as an herbal medicine for several human diseases and ailments in the tropical regions across the globe including the African countries. This study aimed to provide comprehensive information on nutritional benefits, ethnomedicinal uses, phytochemical constituents, pharmacological properties and toxicology study of S. mombin. Information was gathered from documented literatures in scientific database.

Key findings
The study revealed that S. mombin has nutritional values; with the leaf, fruit, flower, seed, and stem bark possessing a wide range of ethnomedicinal uses across several regions, with documented pharmacological properties. S. mombin has a frequent rate of ethnomedicinal utility in cases of abortion, constipation, fever, gonorrhea, postpartum hemorrhage, digestive pain, diarrhoea, dysentery and wounds. Ethnopharmacological studies showed that crude extracts and chemical compounds from S. mombin manifested in vivo and in vitro biological and pharmacological activities. About 102 isolated compounds from the leaf, fruit, or stem bark of S. mombin have been reported.

Summary
Overall, S. mombin has several nutritive and ethnomedicinal benefits owing to its chemical constituents, which are linkable to the several pharmacological activities. There remains however, the need for dosage intake caution, upon the advice of medical professionals.
Optimal timing of a γH2AX analysis to predict cellular lethal damage in cultured tumor cell lines after exposure to diagnostic and therapeutic radiation doses
Authors: Takano Seiya , Shibamoto Yuta , Wang Zhen , Kondo Takuhito , Hashimoto Shingo , Kawai Tatsuya , Hiwatashi Akio 
Published: January 2023

AbstractPhosphorylated H2AX (γH2AX) is a sensitive biomarker of DNA double-strand breaks (DSBs). To assess the adverse effects of low-dose radiation (&lt;50 mGy), γH2AX levels have typically been measured in human lymphocytes within 30 min of computed tomography (CT) examinations. However, in the presence of DSB repair, it remains unclear whether γH2AX levels within 30 min of irradiation completely reflect biological effects. Therefore, we investigated the optimal timing of a γH2AX analysis to predict the cell-surviving fraction (SF). Three tumor cell lines were irradiated at different X-ray doses (10–4000 mGy), and the relationships between SF and relative γH2AX levels were investigated 15 min and 2, 6, 12 and 24 h after irradiation. Data were analyzed for high-dose (0–4000 mGy) and low-dose (0–500 mGy) ranges. Correlations were observed between SF and the relative number of γH2AX foci/nucleus at 12 h only (R2 = 0.68, P = 0.001 after high doses; R2 = 0.37, P = 0.016 after low doses). The relative intensity of γH2AX correlated with SF 15 min to 12 h after high doses and 2 to 12 h after low doses, with the maximum R2 values being observed 2 h after high doses (R2 = 0.89, P &lt; 0.001) and 12 h after low doses (R2 = 0.65, P &lt; 0.001). Collectively, cellular lethal damage in tumor cells was more accurately estimated with residual DSBs 12 h after low-dose (10–500 mGy) irradiation. These results may contribute to determination of the optimal timing of biodosimetric analyses using γH2AX in future studies.
Efficacy of collagenaseClostridium histolyticumin men with congenital penile curvature
Authors: Kulkarni Yogesh , Green Benjamin , Pattillo Curtis , Stirland Isaac , Flores Ashley , Ziegelmann Matthew , Kohler Tobias , Helo Sevann , Trost Landon 
Published: January 2023

AbstractBackgroundCollagenase Clostridium histolyticum (CCH) has been proven effective in multiple subpopulations of PD men; however, no studies have evaluated its role with congenital penile curvature (CPC).AimTo evaluate the safety and efficacy of CCH in men with CPC.MethodsA prospective registry was queried of men undergoing CCH injections at our institution. Beginning in 2016, CCH was administered to CPC men using a similar protocol to PD. A comparative analysis was performed between cohorts to evaluate the safety and efficacy of therapy.OutcomesObjective measures included penile length and curvature, while subjective outcomes included standardized (International Index of Erectile Function and Peyronie’s Disease Questionnaire) and non-standardized assessments. Curvature outcomes were categorized as follows: 1 – included all men, with the most recent assessment considered final, and 2 – only men who had completed eight CCH injections or stopped early due to satisfaction.ResultsFrom 2014 to Oct 2021, a total of 453 men (408 PD, 45 CPC) underwent one or more CCH injections. In comparing cohorts, CPC men were younger (33 vs 58 years, p&lt;0.0001), had lesser baseline curvatures (52.5 vs 65°, p&lt;0.01), more ventral curves (25.7 vs 9.2%, p&lt;0.01), and longer penile lengths (12.5 vs 12.0 cm, p=0.04). Following treatment, both cohorts experienced similar curvature improvements. Specifically, PD men experienced 20-25° or 33-35% improvements depending on definition compared to 25-30° or 40-50% in CPC men (all p-values &gt;0.05). CPC and PD men also demonstrated similar changes on standardized questionnaires, with the exception of the Psychological and Physical subdomain, which was more improved in CPC men (-11 vs -4, p&lt;0.01). Baseline curvature was positively correlated with greater absolute (degree) and relative (percent) improvements. Adverse events were similar between groups after controlling for confounders.Clinical ImplicationsCCH may be safely and effectively administered in men with CPC. These data provide the first evidence for the efficacy of a non-surgical therapeutic option in this cohort.Strengths and LimitationsStrengths – large, prospective series with standardized assessments; Limitations - non-randomized study, short-term follow-up, and lack of standardized method to differentiate CPC from PD.ConclusionsCCH may be safely and effectively administered to men with CPC, with similar success rates compared to PD. Increasing curvature was associated with greater absolute (degree) and relative (percent) improvements, supporting the role for CCH in men with mild, moderate, or severe curvatures. External validation is warranted prior to routine implementation.
Phase Object Reconstruction for 4D-STEM using Deep Learning
Authors: Friedrich Thomas , Yu Chu-Ping , Verbeeck Johan , Van Aert Sandra 
Published: January 2023

Abstract
In this study, we explore the possibility to use deep learning for the reconstruction of phase images from 4D scanning transmission electron microscopy (4D-STEM) data. The process can be divided into two main steps. First, the complex electron wave function is recovered for a convergent beam electron diffraction pattern (CBED) using a convolutional neural network (CNN). Subsequently, a corresponding patch of the phase object is recovered using the phase object approximation. Repeating this for each scan position in a 4D-STEM dataset and combining the patches by complex summation yields the full-phase object. Each patch is recovered from a kernel of 3×3 adjacent CBEDs only, which eliminates common, large memory requirements and enables live processing during an experiment. The machine learning pipeline, data generation, and the reconstruction algorithm are presented. We demonstrate that the CNN can retrieve phase information beyond the aperture angle, enabling super-resolution imaging. The image contrast formation is evaluated showing a dependence on the thickness and atomic column type. Columns containing light and heavy elements can be imaged simultaneously and are distinguishable. The combination of super-resolution, good noise robustness, and intuitive image contrast characteristics makes the approach unique among live imaging methods in 4D-STEM.
Structural snapshots of base excision by the cancer-associated variant MutY N146S reveal a retaining mechanism
Authors: Demir Merve , Russelburg L Peyton , Lin Wen-Jen , Trasviña-Arenas Carlos H , Huang Beili , Yuen Philip K , Horvath Martin P , David Sheila S 
Published: January 2023

AbstractDNA glycosylase MutY plays a critical role in suppression of mutations resulted from oxidative damage, as highlighted by cancer-association of the human enzyme. MutY requires a highly conserved catalytic Asp residue for excision of adenines misinserted opposite 8-oxo-7,8-dihydroguanine (OG). A nearby Asn residue hydrogen bonds to the catalytic Asp in structures of MutY and its mutation to Ser is an inherited variant in human MUTYH associated with colorectal cancer. We captured structural snapshots of N146S Geobacillus stearothermophilus MutY bound to DNA containing a substrate, a transition state analog and enzyme-catalyzed abasic site products to provide insight into the base excision mechanism of MutY and the role of Asn. Surprisingly, despite the ability of N146S to excise adenine and purine (P) in vitro, albeit at slow rates, N146S-OG:P complex showed a calcium coordinated to the purine base altering its conformation to inhibit hydrolysis. We obtained crystal structures of N146S Gs MutY bound to its abasic site product by removing the calcium from crystals of N146S-OG:P complex to initiate catalysis in crystallo or by crystallization in the absence of calcium. The product structures of N146S feature enzyme-generated β-anomer abasic sites that support a retaining mechanism for MutY-catalyzed base excision.
Detection of a bright burst from the repeating fast radio burst 20201124A at 2 GHz
Authors: Ikebe Sota , Takefuji Kazuhiro , Terasawa Toshio , Eie Sujin , Akahori Takuya , Murata Yasuhiro , Hashimoto Tetsuya , Kisaka Shota , Honma Mareki , Yoshiura Shintaro , Suzuki Syunsaku , Oyama Tomoaki , Sekido Mamoru , Niinuma Kotaro , Takeuchi Hiroshi , Yonekura Yoshinori , Enoto Teruaki 
Published: January 2023

Abstract
We present a detection of a bright burst from the fast radio burst (FRB) 20201124A, which is one of the most active repeating FRBs, based on S-band observations with the 64 m radio telescope at the Usuda Deep Space Center/JAXA. This is the first FRB observed by using a Japanese facility. Our detection at 2 GHz in 2022 February is the highest frequency for this FRB and the fluence of &gt;189 Jy ms is one of the brightest bursts from this FRB source. We place an upper limit on the spectral index α = −2.14 from the detection of the S band and non-detection of the X band at the same time. We compare the event rate of the detected burst with those from previous research and suggest that the power law of the luminosity function might be broken at lower fluence and the fluences of bright FRBs are distributed up to over 2 GHz with the power law against frequency. In addition, we show that the energy density of the burst detected in this work is comparable to the bright population of one-off FRBs. We propose that repeating FRBs can be as bright as one-off FRBs and only their brightest bursts might be detected, so some repeating FRBs intrinsically might have been classified as one-off FRBs.
WDFY4 polymorphisms in Chinese patients with anti-MDA5 dermatomyositis is associated with rapid progressive interstitial lung disease
Authors: Guo Li , Zhang Xueliang , Pu Weilin , Zhao Jiangfeng , Wang Kaiwen , Zhang Danting , Hong Soonmin , Ma Yanyun , Wang Xiaodong , Ye Shuang , Guo Qiang , Wang Jiucun 
Published: January 2023

Abstract

Objectives
Anti-melanoma differentiation-associated gene 5 antibody positive dermatomyositis (MDA5+DM), is susceptible to development of rapidly progressive interstitial lung disease (RPILD), which has been predominantly reported in East Asia. A Japanese genome-wide study has identified a WDFY4 variant rs7919656 linkage. We sought to evaluate this genetic marker and exploit its possible clinical relevance in Chinese MDA5+DM.

Methods
We genotyped and compared the minor allele A frequency of WDFY4 rs7919656 in patients with MDA5+DM (n = 254) including 190 clinically amyopathic dermatomyositis (CADM), MDA5-DM (n = 53), anti-synthetases syndrome (ASyS, n = 72) and healthy controls (n = 192). Association of the WDFY4 variant with clinical phenotype was evaluated using logistic regression.

Results
Although the minor allele A frequencies of WDFY4 rs7919656 in MDA5+DM and CADM were comparable to that in healthy controls, we observed a significant correlation between the WDFY4 variant (GA+AA genotype) and the incidence of RPILD in MDA5+DM (OR: 2.11; 95% CI: 1.21, 3.69; P = 0.007). Moreover, this variant was an independent risk factor for RPILD in multivariate analysis (OR: 4.98; 95% CI: 1.59, 17.19; P = 0.008), along with other well-recognized risk factors, i.e. forced vital capacity % predicted, diffusing capacity for carbon monoxide % predicted, serum ferritin and prednisolone exposure. In addition, this variant was associated with higher expression of WDFY4 in PBMCs of MDA5+DM, especially those with RPILD. WDFY4 overexpression was also observed in lung biopsy of MDA5+DM-RPILD bearing the variant genotype.

Conclusion
We found that the WDFY4 variant was associated with an increased risk of RPILD, not with disease susceptibility in Chinese MDA5+DM.
Pain specialist management of sexual pain–III. Neuromodulation
Authors: Vogel John J 
Published: January 2023

AbstractIntroductionSome women with sexual pain do not respond to conservative multi-modal care modalities. Neuromodulation is a group of methods which alter nerve activity by delivering electrical energy or pharmaceutical agents directly to target neural structures. Multiple forms of neuromodulation may provide durable treatment options to fill the unmet therapeutic need of a certain population of women with chronic sexual pain.ObjectivesTo provide a current review of neuromodulation treatments used for female sexual pain and introduce neuromodulation techniques which may be applied in novel ways to specific sexual pain phenotypes.MethodsInternet, PubMed and Cochrane Library were searched for relevant articles on female sexual pain within the clinical purview and scope of practice of pain management.ResultsA thorough review of the literature was conducted to include basic science studies, clinical trials, systematic reviews, consensus statements, and case-reports. A sampling of information on real-world patient outcomes was included. The amount and quality of evidence for neuromodulation to treat female sexual pain is low-moderate. Descriptions of neuromodulation procedures for sexual pain were made and clinical studies reviewed. The effects of autonomic nervous system (ANS) dysregulation on the experience of pain were discussed with consideration of interventional procedures to facilitate restoration of ANS equilibrium.ConclusionTreating female sexual pain is complex. There are considerable numbers of women who have unsatisfactory sexual pain relief despite evidence-based interdisciplinary care. These women may benefit from referral to consider neuromodulation treatment options. Neuromodulation is a relatively new capability in the arsenal of pain management and other specialists that can be considered for women with treatment refractory sexual pain.
Impact of various buffers and weak bases on lysosomal and intracellular pH: Implications for infectivity of SARS‐CoV‐2
Authors: Kraut Jeffrey A. , Cheetham‐Wilkinson Izaak J. , Swan Laura E. , Stagi Massimiliano , Kurtz Ira 
Published: January 2023

AbstractAcidification of the cellular lysosome is an important factor in infection of mammalian cells by SARS‐CoV‐2. Therefore, raising the pH of the lysosome would theoretically be beneficial in prevention or treatment of SARS‐CoV‐2 infection. Sodium bicarbonate, carbicarb, and THAM are buffers that can be used clinically to provide base to patients. To examine whether these bases could raise lysosomal pH and therefore be a primary or adjunctive treatment of SARS‐CoV‐2 infection, we measured lysosomal and intracellular pH of mammalian cells after exposure to each of these bases. Mammalian HEK293 cells expressing RpH‐LAMP1‐3xFLAG, a ratiometric sensor of lysosomal luminal pH, were first exposed to Hepes which was then switched to sodium bicarbonate, carbicarb, or THAM and lysosomal pH measured. In bicarbonate buffer the mean lysosomal pH was 4.3 ± 0.1 (n = 20); p = NS versus Hepes (n = 20). The mean lysosomal pH in bicarbonate/carbonate was 4.3 ± 0.1 (n = 21) versus Hepes (n = 21), p = NS. In THAM buffer the mean lysosomal pH was 4.7 ± 0.07 (n = 20) versus Hepes (4.6 ± 0.1, n = 20), p = NS. In addition, there was no statistical difference between pHi in bicarbonate, carbicarb or THAM solutions. Using the membrane permeable base NH4Cl (5 mM), lysosomal pH increased significantly to 5.9 ± 0.1 (n = 21) compared to Hepes (4.5 ± 0.07, n = 21); p < 0.0001. Similarly, exposure to 1 mM hydroxychloroquine significantly increased the lysosomal pH to (5.9 ± 0.06, n = 20) versus Hepes (4.3 ± 0.1, n = 20), p < 0.0001. Separately steady‐state pHi was measured in HEK293 cells bathed in various buffers. In bicarbonate pHi was 7.29 ± 0.02 (n = 12) versus Hepes (7.45 ± 0.03, [n = 12]), p < 0.001. In cells bathed in carbicarb pHi was 7.27 ± 0.02 (n = 5) versus Hepes (7.43 ± 0.04, [n = 5]), p < 0.01. Cells bathed in THAM had a pHi of 7.25 ± 0.03 (n = 12) versus Hepes (7.44 ± 0.03 [n = 12]), p < 0.001. In addition, there was no statistical difference in pHi in bicarbonate, carbicarb or THAM solutions. The results of these studies indicate that none of the buffers designed to provide base to patients alters lysosomal pH at the concentrations used in this study and therefore would be predicted to be of no value in the treatment of SARS‐CoV‐2 infection. If the goal is to raise lysosomal pH to decrease the infectivity of SARS‐CoV‐2, utilizing lysosomal permeable buffers at the appropriate dose that is non‐toxic appears to be a useful approach to explore.