bluuebunny/crossref_metadata_2025_split huggingface dataset:
Brain and lung metastasis of uterine leiomyosarcoma: illustrative case
Authors: Richards Hunter , Alsalek Samir , Laiwalla Azim , Attiah Mark , Harary Maya , Kim Wi Jin , Hirt Daniel , Rahman Shayan U. 
Published: May 2023

BACKGROUND
Uterine leiomyosarcoma is a rare, extremely aggressive tumor with a high rate of metastasis. Five-year survival for individuals with metastatic disease is only 10%–15%. Metastases to the brain are exceptionally rare and are associated with poor survival.

OBSERVATIONS
The authors report a case of uterine leiomyosarcoma that metastasized to the brain in a 51-year-old woman. A single lesion on magnetic resonance imaging was discovered in the right posterior temporo-occipital region 44 months after resection of the primary uterine tumor. The patient underwent a right occipital craniotomy with gross-total resection of the tumor and is receiving adjuvant stereotactic radiosurgery and chemotherapy with gemcitabine and docetaxel. At 8 months postresection, the patient remains alive and asymptomatic with no sign of recurrence. A literature review of prior reported cases was conducted to analyze patterns of approach to patient treatment and survival.

LESSONS
The authors found an apparent survival benefit in patients receiving adjuvant radiation therapy.
Stereotactic radiosurgery for recurrent skull base polymorphous adenocarcinoma invading the cavernous sinus: illustrative case
Authors: Rai Yurie , Umekawa Motoyuki , Shinya Yuki , Hasegawa Hirotaka , Katano Atsuto , Kondo Kenji , Shinozaki-Ushiku Aya , Saito Nobuhito 
Published: May 2023

BAKGROUND
Polymorphous adenocarcinomas (PACs) are rare tumors arising from the salivary glands. Radical resection and postoperative radiotherapy are the mainstays of treatment. However, complete tumor resection is not always achievable when the tumor invades the skull base. Stereotactic radiosurgery (SRS) could be a less invasive alternative for treating skull base PACs.

OBSERVATIONS
A 70-year-old male with a history of surgery for a right palatine PAC presented with right visual impairment, diplopia, and ptosis. Imaging studies revealed tumor recurrence invading the right cavernous sinus (CS). SRS using a gamma knife was performed for this recurrence, prescribing a marginal dose of 18 Gy at a 50% isodose line. Five months after SRS, his symptoms were relieved, and the tumor was well-controlled for 55 months without any adverse events.

LESSONS
To the best of the authors’ knowledge, this is the world’s first case of recurrent skull base PAC invading the CS that was successfully treated with salvage SRS. Thus, SRS may be an applicable treatment option for skull base PACs.
Using a low-metal–density stent for thrombectomy-resistant vertebrobasilar occlusion due to thrombus migration from a thrombosed vertebral artery aneurysm: illustrative case
Authors: Yoshida Koji , Akamatsu Yosuke , Tsutsui Shota , Ogasawara Yasushi , Misaki Toshinari , Konno Hiromu , Ogasawara Kuniaki 
Published: May 2023

BACKGROUND
Thrombosed intracranial aneurysms can lead to large vessel occlusion as a result of spontaneous thrombosis. Although mechanical thrombectomy is likely effective, recurrent thromboembolism can occur if the thrombotic source remains untreated. The authors describe a case of recurrent vertebrobasilar artery occlusion due to thrombus migration from a large thrombosed vertebral artery (VA) aneurysm that was successfully treated with mechanical thrombectomy followed by stenting.

OBSERVATIONS
A 61-year-old male previously diagnosed with a large, thrombosed VA aneurysm presented with right hypoesthesia. Imaging on admission showed left VA occlusion and an acute ischemic lesion in the left medial medulla. His symptoms worsened, with complete right hemiparesis and tongue deviation occurring 3 hours after admission, and mechanical thrombectomy was performed to recanalize the left-dominant VA. Despite several attempts, reocclusion of the vertebrobasilar system occurred after each mechanical thrombectomy because of repeated thrombus formation in the thrombosed aneurysm. Therefore, a low-metal–density stent was deployed to prevent thrombus migration into the parent artery, which resulted in complete recanalization and rapid improvement of the symptoms.

LESSONS
Stenting with a low-metal–density stent for recurrent embolism secondary to thrombus migration from a large thrombosed aneurysm was feasible in the acute stroke setting.
PEMENUHAN HAK ASASI MANUSIA ATAS LINGKUNGAN HIDUP YANG SEHAT
Authors: Nugroho Anastasha Ruth , Fatma Ulfatun Najicha  
Published: May 2023

The environment is an accumulation of the interaction of various factors contained in the biotic and abiotic environment. Juridically, it is constitutionally stated that a healthy environment is a form of human rights that must be fulfilled by the state. However, it is undeniable that currently there is a lot of damage to a healthy environment, which means that the state cannot fulfill its responsibilities. This paper will examine the definition of a healthy environment and how efforts to fulfill a healthy environment as part of human rights. This paper uses a normative juridical approach that refers to primary and secondary legal materials. With this approach, the results of the study state that a good and healthy environment is an environment that can allow humans to develop optimally, in harmony, harmony, and balance. Meanwhile, efforts to fulfill a healthy environment can be realized if the government and the community work together in realizing this right accompanied by law enforcement against a healthy environment.

Keyword : healthy environment, human rights , law enforcement
The association between marathon running and high-sensitivity cardiac troponin: A systematic review and meta-analysis
Authors: Dong Xueping , Zhao Yikun , Zhao Zhen , Fang Jiajin , Zhang Xintao 
Published: May 2023

BACKGROUND: Marathon running is an extreme sport with a distance of about 42 kilometers. Its relationship to high-sensitivity cardiac troponin (hs-cTn) remains controversial. OBJECTIVE: As the gold standard for detecting myocardial injury, the trends of hs-cTn before and after a marathon were investigated and analyzed. METHODS: A literature search was conducted in PubMed, EMBASE, and Cochrane Library databases by combing the keywords marathon and troponin, and studies regarding high-sensitivity cardiac troponin I (hs-cTnI) and high-sensitivity cardiac troponin T (hs-cTnT) concentrations before and after marathon running (not for half-marathon and ultra-marathon) were included. “Quality Assessment Tool for Before-After (Pre-Post) Studies With No Control Group” were used to assess the risk of bias. Statistical analysis was performed using Review Manager, presenting data as mean values and 95% confidence intervals (CIs). Sensitivity analysis and subgroup analysis were performed if there was high heterogeneity among studies based on I2 statistic. RESULTS: A total of 13 studies involving 824 marathoners were included in this systematic review and meta-analysis. Both hs-cTnI (MD 68.79 ng/L, [95% CI 53.22, 84.37], p< 0.001) and hs-cTnT (MD 42.91 ng/L, [95% CI 30.39, 55.43], p< 0.001) were elevated after running a marathon, but the concentration of hs-cTnT returned to baseline after 72 to 96 h post-race (MD 0.11 ng/L, [95% CI -1.30, 1.52], p= 0.88). The results of subgroup analysis demonstrated that the 99th percentile upper reference limit of hs-cTnT might be the source of heterogeneity. CONCLUSION: The concentrations of hs-cTnI and hs-cTnT were increased after marathon running, but the change of hs-cTnT is usually not seen as irreversible myocardial injury.
FEATURES OF AMBULATORY BLOOD PRESSURE MONITORING WITH DIFFERENT BLOOD PRESSURE PROFILES IN PATIENTS WITH HYPERTENSION DISEASE OF MIDDLE AND ELDERLY AGE
Authors: Pasko V.S. 
Published: May 2023

Background. Insufficient night-time reduction of blood pressure (BP) and night hypertension are associated with an increased risk of death regardless of the average daily BP. The study of daily BP profiles is very relevant in patients with hypertension of different age categories due to the high risk of thrombotic complications.
Aim: of the study was to determine the peculiarities of ambulatory blood pressure monitoring (ABPM) indices in middle-aged and elderly hypertensive patients depending on the daily BP profile.
Materials and methods. ABPM indicators were determined in 125 patients who were divided into 2 groups. 1st group (n=82) – middle-aged hypertensive patients (45-59 years old); 2nd group (n=43) – elderly hypertensive patients (60-74 years old). In the groups of middle-aged and elderly subjects 2 groups of daily BP profiles were distinguished: "dipper" and "non-dipper".
Indices of ABPM were determined using a portable recorder ABPM-04 (company "Meditech", Hungary). Measurements of BP were performed every 15 minutes during the day (from 6 to 22 hours) and every 30 minutes at night (from 22 to 6 hours). We determined the following indices: the average daily systolic BP (SBP) (mm Hg), the average daly diastolic BP (DBP) (mm Hg), the average BP (mm Hg); the maximal daily SBP (mm Hg), the maximal daily DBP (mm Hg). The daily index (DI) was also calculated − the percentage of BP decrease at night compared to daytime BP calculated in % DI of SBP, DI of DBP, DI of average BP.
Results. The baseline BP level in the average daily SBP and DBP in middle-aged patients of dipper group was significantly higher by 49,6% and corresponded to 155,9±12,0 mm Hg (p<0,001) and 50,4% and was 97,3±6,1 mm Hg (p<0,01). Similar results are observed in the average BP and the maximal daily SBP and the maximal daily DBP values which were significantly higher than the control group by 21,5% (p<0,05) and equaled 110,0±3,6 mm Hg and 21,3% and amounted to 176,3±23,5 mm Hg (p<0,05) and 23,6% and amounted to 117,0±19,2 mm Hg (p<0,05). The baseline BP level in the average daily and maximal SBP, the average daily DBP and the average BP in patients of non-dipper group was significantly higher by 50,8% (p<0,01) and corresponded to 157,1±12,9 mm Hg and 27,4% and equal to 176,9±24,0 mm Hg (p<0,05), 63,8% and amounted to 106,0±1,0 mm Hg (p<0,05) and 44% and was 124,3±6,8 mm Hg (p<0,05) too. In the surveyed elderly patients only the average daily DBP was significantly different from the corresponding control indicator and was lower by 21,4% (p<0,05) and amounted to 91,5±0,7 mm Hg in dipper and 23,1% (p<0,01) and was 93,5±0,7 mm Hg in non-dipper group.
Conclusion. Non-dipper group predominates in the structure of daily BP rhythm in elderly hypertensive patients (62,8% versus 37,2%). The average BP decreases in elderly patients of non-dipper group by 11,1% (p<0,05) reliably to patients of middle age.
COMPARATIVE STUDY OF FLEXURAL STRENGTH OF PHOTOCOMPOSITE DENTAL ENAMEL SEALANTS
Authors: Noenko I.V. , Pavlenko O.V. , Mochalov I.O. 
Published: May 2023

Background. Dental caries is a widespread worldwide disease of multifactorial genesis. The leading mechanism of its development is a long-term imbalance of the physiological balance between the inorganic component of the teeth hard tissues and the liquid biofilm formed on their surface, the predominance of the demineralization processes in hard tissues over the processes of remineralization. The use of dental enamel sealants has proven to be effective in preventing and reducing the intensity of dental caries. Modern bioactive polymer sealants for enamel contain such remineralizing agents as sodium fluoride, nanoamorphous calcium phosphate, beta-tricalcium phosphate, and particles of bioactive glass. For all dental composite filling materials, mechanical stability is one of the prerequisites for the long-term clinical success of restorations and fillings, and accordingly, temporary protective structures made of sealants.
Aim: to compare the flexural strength and modulus of elasticity of three modern photocomposite enamel sealants.
Materials and methods. In laboratory conditions for three modern photocomposite dental materials for sealing fissures and pits of enamel "Fissurit FX" (VOCO), "Clinpro™ Sealant" (3M™ ESPE™) and "Jen-Fissufil" (Jendental-Ukraine LLC) a flexural strength (three-point test) and elastic modulus were determined in accordance with the requirements of the international standard ISO 4049:2019. 6 samples of each material, polymerized and kept for a day in humid conditions, were examined.
Results. The highest elastic modulus and flexural strength were in "Fissurit FX" – 5.17±0.80 GPa (M=5.00 GPa) and 130.07±7.75 MPa (M=127.81 MPa), respectively. In "Clinpro™ Sealant" the elastic modulus was 2.97±0.12 GPa (М=3.00 GPa), the flexural strength was 100.01±14.33 (М=96.73) MPa. In "Jen-Fissufil" the elastic modulus was 3.47±0.52 GPa (M=3.17 GPa), the flexural strength was 90.91±6.66 MPa (M=93.02 MPa). The studied indicators of all three materials exceeded the requirements of the international standard ISO 4049:2019.
Conclusion. The performed studies showed high mechanical properties of all three dental sealants for enamel and that they have the potential to withstand long-term periodic masticatory load when functioning on the surface of teeth.
FEATURES OF EXTERNAL RESPIRATION OF ADOLESCENTS OF DIFFERENT MEDICAL GROUPS OF PHYSICAL EDUCATION
Authors: Usova O. V. , Sologub O.V. , Ulianytska N.Y. , Yakobson O.O. , Ushko Ia.A. , Sitovskyi A.М. , Haiduchyk P.D. 
Published: May 2023

Relevance. One of the human systems, which is particularly acutely affected by external environmental factors is the respiratory system. These disorders in adolescence are especially noticeable when intense and dramatic changes in the child's body on the path to biological maturity occur.
Goal. The purpose of our study was to evaluate the functional indexes of the external respiration of adolescents of different medical groups of physical training.
Materials and methods. The functionality of the respiratory system was evaluated by the results of pneumothography and respiratory retention. They were evaluated using mathematical statistics using the Medstat program (Yu.E.E., 2006). 76 middle school age pupils (38 boys and 38 girls) were surveyed, which belong to the preparatory group of physical training and 40 peers (20 boys and 20 girls) who attend the main physical education group. For comparison, normal indexes were used according to computer conclusions and scientific literature data
Results. The normal performance of the VC according to the results of computer conclusions, registered in 42 % of pupils of the preparatory group of physical education, higher than the norm have 21 % of adolescents, 36 % of adolescents have significant violations of this index. According to the computer's conclusion, 52% of the subjects are characterized by extremely significant changes of FVC. A similar pattern is also noted for the index in the boys of this group. According to the results of computer findings 69% of pupils of the preparatory group have normal indexes of PEF, 21% have a higher then norm, 10% a slight decrease. The results of the functional test of Shtanger (delay in inhalation) showed that in the preparatory group this index is lower than the norm
Volumetric indicators of the external respiration of pupils of the preparatory group in more than half of adolescents are significant changes. The volumetric indexes of such adolescents are significantly lower than the norm, by almost 1 liter. The rates of the respiratory system of the MEF 25, 50, 75% are lower than the norm by 1.5 - 2 times, and PEF does not differ from the norm.
Conclusions. Indexes of external respiration in more than half of the examined pupils of the preparatory group were changed. The volumetric and flow rates of the respiratory system were significantly lower than the norm. A similar trend was followed by functional respiratory tests.
ANTIMICROBIAL PROPERTIES OF FILTERING FIBROUS MATERIALS IMPREGNATED BY AMINOMETHANESULPHONIC ACIDS
Authors: Hrydina T.L. , Khoma R.E. , Fedchuk A.S. , Hruzevskyi O.A. , Shevchuk H.Yu. , Ishkov Yu.V. 
Published: May 2023

Background. The spread of a new strain of SARS-CoV-2 and the pandemic that caused it has led to huge changes around the world. So, it reminded us again about the importance of developing measures for the prevention of infections that transmitted by air droplets.
Aim: investigation of the antimicrobial activity of aminomethanesulfonic acid (AMSA) and its derivatives (N-(2-hydroxyethyl)-(HEAMSA), N-benzyl-(BnAMSA) and N-(tert-butyl)-(t-BuAMSA)) which impregnated on filtering fibrous material and can be used for the manufacture of anti-aerosol elements of individual respiratory protection against strains of Staphylococcus aureus with different level of antibiotics resistance.
Materials and methods. The standard method of Kirby and Bauer disks is used for the investigation of the specific activity of antimicrobial drugs. The 24-hour cultures of microorganisms that contained (1.2+0.2)x109 CFU/ml were diluted according to the turbidity standard. The results were detected after 18-20 hours of incubation at 37°C. The 0.5 cm diameter filter fibrous discs contained the following compounds: AMSA, HEAMSA, BzAMSA, t-BuAMSA and streptocide (sulfanilamide) as a reference with active compound content (Q) at a final concentration of 0.047 and 0.236 mmol/g.
Results. All test samples with aminomethanesulfonic acids at a final concentration of 0.236 mmol/g that were applied to the filter fibrous material had a higher level of inhibition of the growth of the microorganisms than the prototype using streptocide (sulfanilamide) e against the strains of Staphylococcus aureus 2781 and Staphylococcus aureus Kunda.
Conclusions. Samples based on HEAMSA showed the greatest antimicrobial activity against the studied strains of Staphylococcus aureus from all research samples of filter fibrous material with YAMSA. They were characterized by the maximum hydrophilicity and the minimum value of the empirical pKa function lgPow. AMSA and HEAMSA were characterized by the smallest particle sizes on the surface of lavsan fiber according to electron microscopy analysis. This provides the largest boundary of contact between the phases of these biocides in the composition of the filtering fibrous material with bio aerosols during respiratory air purification.
THE USE OF STEM CELLS IN THE TREATMENT OF DIABETES
Authors: Cui Yun Kai , Shemet Ya.A. , Ziablitsev S.V. 
Published: May 2023

Background. The article is devoted to an analytical review of the methods of using stem cells in the treatment of diabetes mellitus (DM).
Aim: to analyze, based on the data of the literature, the prospects of using stem cells for the treatment of DM.
Materials and methods. Review of scientific literature in the international electronic scientometric databases PubMed, Scopus, Web of Science by keywords for the period 20017-2023. The search was carried out by three independent authors. 98 sources were selected for analysis, of which 33 were used that met the search criteria.
Results. DM is a serious problem for the health care system worldwide, which requires the development of new innovative and effective therapeutic approaches. The use of stem cells is one such promising strategy for solving this problem. The ability of stem cells to differentiate into various body cells, including beta cells of the pancreas, was analyzed. Animal studies have demonstrated the ability to improve insulin synthesis and lower blood glucose levels. The use of stem cells in the treatment of DM is not a widespread approach and requires additional clinical studies. General information on the use of stem cells in the treatment of diabetes is presented and the prospects of this method of therapy are outlined.
Conclusions. The use of stem cells in the treatment of diabetes is a promising technology that may open new opportunities for the treatment of this disease. However, more research needs to be done, a number of technical, ethical, and legal issues need to be addressed, as well as regulatory standards for the production and use of stem cells.
Therapeutic study of the nausea and vomiting caused by chemotherapy medications by olanzapine to triple antiemetic therapy in Iraqi cancer patients
Authors: Ghufran salah ahmed  , Khadim ali khadim2  , Nabeel mudheher talib  
Published: May 2023

Background:Chemotherapy-caused nausea and vomiting is a health problem in cancer patients. Olanzapine is used with serotonin receptor antagonists plus dexamethasone post Neurokinin 1 receptor antagonists as the antiemetic.
Objective: The study aimed to determine the efficacy of (5 and 10) mg of olanzapine with antiemetic drugs against chemotherapy-induced nausea and vomiting.
Methods: The study groups are Group S: received triple antiemetic therapy aprepitant at (1-3) day, dexamethasone at (1-4) day, and ondansetron only on the first day. Group O5: received olanzapine 5 mg with triple antiemetic therapy aprepitant (1-3) days, dexamethasone (1-4) day, ondansetron the first day, and olanzapine 5 mg (1-4) days. Group O10: received (olanzapine 10 mg with triple antiemetic therapy) aprepitant (1-3) days, dexamethasone (1-4) days, ondansetron day 1, and olanzapine 10 mg (1-4) days. The cancer was diagnosed by mamograph; the MAT score was used to control chemotherapy-caused nausea and vomiting.
Results: Higher acute and delayed nausea was observed in group S than in groups O5 and O10. Overall, nausea control was increased in group S than in groups O5 and O10. There was no significant difference between the different study groups.
Conclusion: Olanzapine 5 mg and 10 mg could treat nausea more than triple antiemetic in patients with nausea.
Evaluation the Effect of Sublingual Glutathione on the Quality of Life in COPD Patient by Using Saint George respiratory questionnaire
Authors: Ali H. Farag  , Wassan A. Abass  , Hyder S. Qassem  
Published: May 2023

Background: Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory disorder of the airways associated with airway narrowing with airflow obstruction leading to difficulty in breathing impair daily activity and cause poor quality of life. Patients and methods: Fifty patients whom diagnosed with COPD are divided into two groups, 1st control group includes 25 patients assigned to receive conventional therapy of Formoterol fumarate 12 microgram inhaler twice daily, and 2nd interventional group also includes 25 patients assigned to receive conventional therapy with (300 mg/ 2 times daily) sublingual glutathione for two months. Saint George respiratory questionnaire (SGRQ) were measured before and after first and second months after treatment in both study groups. Aim of the study: This study was object to assess the changes in quality of life by using SGRQ following sublingual glutathione supplements therapy in COPD patients. Results and conclusion: After two months treatment , the mean values of SGRQ showed a significant increase compared to pre-treatment levels in both groups (P<0.01). There was highly significant improvement in SGRQ in both COPD patients groups after 2 months of treatment with much significant improvement in intervention group which may indicate the beneficial effects of adding glutathione sublingually administered supplements in COPD patients conventional therapeutic regiment.
Методологічні аспекти формування стратегії розвитку вищого військового навчального закладу
Authors: Коваль М. В. , Пунда Ю. В. , Артамощенко В. С. 
Published: May 2023

У статті наведено методологічний підхід до формування стратегії розвитку вищих військових навчальних закладів (ВВНЗ) за процесами стратегічного управління. Під час стратегічного аналізу вивчають макрооточення, безпосереднє оточення, внутрішнє середовище та формулюють місію та візію ВВНЗ. Акцентовано увагу, що напрями розвитку ВВНЗ визначають за співставленням місії, візії та наявних спроможностей. Запропоновано оцінювати спроможності ВВНЗ за складовими DOTMLPFI.
Процеси стратегічного управління ВВНЗ проілюстровані у статті на прикладі розроблення проєкту документа «Стратегія і перспективні напрями розвитку освітньої діяльності Національного університету оборони України на період 2023–2027 років».