bluuebunny/crossref_metadata_2025_split huggingface dataset:
Determinants of Quality of Life in Women living with Breast Cancer in Southwest Nigeria
Authors: Opadola Oluwafunbi , Opadola Omodele , Ojedokun Samson , Abayomi Olukayode 
Published: December 2022

Background: The quality of life (QOL) among women with breast cancer is hampered in areas of social, emotional, and sexual functioning and this could persist even years after treatment. It is an important parameter for monitoring disease progression at the early stage. Hence, this study aimed to determine the factors associated with the overall quality of life among subjects living with breast cancer.
Methods: The study was a comparative cross-sectional design conducted among women with breast cancer attending the General Surgical Outpatient clinic of LAUTECH Teaching Hospital Ogbomoso and a comparison group of age-matched control. The instrument used include the World Health Organization Quality of Life-BREF and socio-demographic and clinical variable questionnaire in 240 interviewer-administered questionnaires. Data were analyzed using SPSS version 21. A P-value of less than 0.05 was taken as statistically significant. The predictors of overall QOL were analyzed using a binary logistic regression.
Results: All QOL domain scores were significantly higher among controls than in subjects with breast cancer. ρ-value = 0.001. Level of education and duration of diagnosis had a statistically significant association with the overall quality of life, P-value< 0.05. Respondents who attained a tertiary level of education were 0.040 times less likely to have a poor quality of life compared to respondents that were not educated (P-value= 0.038) and the odds of having a poor overall quality of life decreased with duration since diagnosis P-value= 0.049.
Conclusion: Our study shows that women with breast cancer experience a lower QOL, especially in the physical, psychological and social domains than women without the disease. Also, the level of education, employment and marital status, and duration since diagnosis were major factors influencing QOL. Assessment of QOL is an important metric that should be incorporated into the breast cancer treatment program.
Constraints Faced by Cotton Farmers in Management of Cotton Cultivation in Madhya Pradesh, India
Authors: Singh Shivpal , Patel M. M. 
Published: December 2022

The study was conducted in ten purposively selected villages of Khandwa district of Madhya Pradesh on the basis of large area under cotton crop and a total of 200 farmers selected by the proportionate random sampling technique. An interview schedule was prepared for collection data relating to constraint faced by cotton growers. They faced in growing cotton to lack of knowledge about improved scientific practices in cotton crop (89.50%), insufficient training programs (88.00%), insufficient demonstration of improved technology (83.50%), lack of technical knowledge about pheromone and sticking trap (81.00%), high price & poor quality of Bt. cotton seeds (79.50%), lack of information regarding upcoming abnormal weather conditions (78.00%), lack of coordination between farmer and agriculture institution (76.50%), scarcity of labour at the plucking stage (73.50%), a decline in the yield of cotton due to insects (71.00%), lack of technical knowledge about the recommended insecticide, pesticide, fungicide and herbicide (68.00%), high costs of fertilizers (65.50%), uneven electricity supply (65.00%), lack of expertise in identifying the crop's pests, diseases, and weeds (63.50%). Farmer has not proper knowledge about improved cultivation practices of cotton crop. So famer should be provided the various training programmes be organized to provide practical knowledge and field demonstrations should be arranged on improved practices.
Determination of Optimum Dietary Carbohydrate Level of Long Whiskers Catfish, Mystus gulio Fry
Authors: Khatua Rooprekha , Mohanta Kedar Nath , Chandan Nitish Kumar , Pattanayak Rojalin , Mishra Choudhury Suryakant , Kumar Prem 
Published: December 2022

The objective of the present study is to evaluate the optimum dietary carbohydrate level of M. gulio fry, which will form the basis for formulating the nutritionally adequate, cost-effective nursery diet. Five iso-proteinous (400 g kg-1 diet) and iso-lipidic (120 g kg-1 diet) semi-purified diets with 100, 150, 200, 250 and 300 g carbohydrate kg-1 diet were fed ad libitum to Mystus gulio fry (0.33 ± 0.004 g) for 90 days in triplicates (10 fish/replicate). Fifteen fibre-reinforced plastic tanks (50 L) with flow-through system (water flow rate of 0.5 L min-1) were used for rearing the fish. At the end of the feeding period, the diet containing 200 g kg-1 carbohydrate diet had significantly higher (P = .05) weight gain (8.39 g), Specific Growth Rate (SGR; 3.62 %/day), Protein Efficiency Ratio (PER; 1.52), Protein Productive Value (PPV; 24.08%), Lipid Productive Value (LPV; 27.13%), Energy Productive Value (EPV; 66.89%) and lower Food Conversion Ratio (FCR; 1.65) as compared to other diet fed groups. The fish fed with carbohydrate beyond 200 g kg-1 diet had significantly higher (P = .05) Hepatosomatic index (HIS) and Visecerosomatic index (VSI) than the lower carbohydrate fed groups. Second order polynomial regression analysis of weight gain, SGR, FCR, PER and PPV against the dietary carbohydrate had showed that the optimum dietary carbohydrate requirement of M. gulio fry is 197.8-207.3 g kg-1 diet.
In vitro Anti-inflammatory and Anti-cholesterolemic Activities of Chrysanthellum americanum (L) Vatke Harvested in Mali
Authors: Koné Moussa Oumou , Togola Issiaka , Konaré Mamadou Abdoulaye , Diarra Nouhoum , Sanogo Rokia , Karembé Moussa 
Published: December 2022

Aims: The objective of this study was to evaluate the anti-inflammatory and anticholesterolemic activities of Chrysanthellum americanum extracts.
Place and Duration of Study: The plant material was harvested in September 2021 at Findiala located in Kolondièba, Mali. The phytochemical screening and evaluation of anti-inflammatory and anticholesterolemic activities were performed at the Laboratory of Plant and Food Biochemistry and Biotechnologies of the University of Sciences, Techniques and Technologies of Bamako (Mali) from September 2021 to January 2022.
Methodology: The phytochemical screening based on classical methods was performed. The in vitro anti-inflammatory activity was determined by the protein denaturation method. The binding capacity of protein hydrolysates to bile salts was used to evaluate the anticholesterolemic activity.
Results: The screening of C. americanum extracts revealed the presence of numerous secondary metabolites including alkaloids, polyphenols, and flavonoids. These extracts at different concentrations showed a good anti-inflammatory activity in vitro. Indeed, at 1 mg/mL of extracts with protein denaturation inhibition rates ranging from 73.33% to 79.42% respectively for infusion and decoction, against 93.33% for diclofenac (positive control). Cholesterol reduction rates ranging from 36.28±2.44% to 72.37±2.29% were recorded. Trypsin hydrolysates showed the best results with 72.37% binding to sodium cholate after 90 minutes followed by the decoction with 58.30% binding to sodium deoxycholate after 90 minutes of hydrolysis with infusion.
Conclusion: The data obtained from this study show the richness in anti-inflammatory and anticholesterolemic activities of C. americanum extracts. Therefore, this species could be a promising source of anti-inflammatory and anticholesterolemic agents.
Homemakers’ Attitude towards Solid Waste Management in Urban Area of Hubli-Dharwad
Authors: Kurbett Roopa , Channalli P. Shilpa , Rebasiddanavar Revappa M. 
Published: December 2022

Proper waste management is a major concern of public health. It is necessary to create positive behavioral changes toward waste management among the public to control diseases. Objectives were to determine the attitude toward solid waste management among the households of Hubli - Dharwad city in Karnataka, India. A community based cross sectional study was conducted in 67 wards of Hubli- Dharwad city located in the Dharwad district of Karnataka state from January 2021 to December 2021. A total of 400 households were studied and multistage sampling was done. Data was collected by direct interview using a pre-questionnaire and analyzed using SPSS software. The participants responsible for waste management in the household were women. Out of the 400 participants, 83%, 11% and 6% were Hindus, Muslims and Christians respectively. The majority of them (82%) had an educational qualification of high school and were housewives. About 47% of the study population belongs to the upper middle class. Their major sources of information about solid waste management were Self Help Groups (SHGs). In the study, 93.8% of the studied population had above average attitudes and 6.2% had below average attitudes toward household waste management. Almost 70% had the belief that the government is not doing anything to fix the garbage problem. About 97%, 88.6% and 92% were willing to do composting, segregation and recycling of waste respectively. . Continuous awareness programs have to be conducted on safe waste disposal and efforts should be made to sustain the supervision of household waste management.
Herpes Zoster (Shingles) Infection Following COVID-19 Vaccination: An Association or Coincidence?
Authors: Kazi Shoaib , Abdelhamid Mohamed , Fehaidi Alanoud Al , Hamed Ehab Said 
Published: December 2022

Since early 2020, and till early 2022 the world suffered COVID-19 pandemic. Thanks to medical science for developing a fast track and effective COVID-19 vaccine which is aimed to reduce the infection rates and provide sufficient immunity. Clinicians worldwide are monitoring possible side effects and adverse events of the different COVID-19 Vaccines. In this case series, we report 4 cases of Herpes Zoster infection noted in patients after having COVID-19 vaccine including Pfizer, Moderna and Sinopharm Vaccines.
Discussion and Conclusion: We present 4 patients who were reviewed in the outpatient clinics presenting with an erythematous, painful, blistering, unilateral rash which was typical of Herpes Zoster infection following COVID-19 vaccination. They were between 23-54 years of age and had no significant past medical history. We suspect the eruption of Herpes Zoster rash is likely linked to COVID-19 vaccination. However, this could also be a mere coincidence. Further research is needed to establish a proven link.
A Study to Determine the Prevalence of Weak D in Donors and Patients at a Tertiary Care Teaching Hospital in Telangana
Authors: Mamatha M. , B. S. Vani , Akarapu Jostnadevi , Enumula Deepthi 
Published: December 2022

Introduction: The Rhesus (Rh) blood group system is considered the next most important after ABO. It is of clinical significance in regard to transfusion and pregnancy. The Weak D phenotype (Du)is a weakened form of D antigen that cannot be detected by routine grouping (using immediate spin tube methodology).
Aims:
1) To determine the prevalence of weak D.
2) To assess the implications in terms of alloimmunization.
3) To provide knowledge on the weak D status and enhance the importance of weak D determination in the donor and patient population.
Study Design: A retrospective study.
Place and Duration of Study: Licensed blood bank in Malla Reddy Narayana Multispecialty Hospital under Department of Pathology, data from blood bank records was collected from 1st of August 2018 to 31st of July 2019.
Methodology: It was a one-year study at a tertiary care centre and study group included both donors and patients who were admitted and those attending outpatient departments who were identified for blood grouping test at the blood bank. Data was collected from the blood bank records.
Results: A total of 4054 blood samples were analysed out of which of 3405 were Rh D positive and 649 samples were RhD negative. On further testing 12 out of 649 Rh D negative, were found to be weak D positive.
Conclusion: For a safer transfusion and to prevent alloimmunisation it is recommended to develop protocols for weak D testing for the individuals who are Rh D negative on routine testing in regions showing significant prevalence.
Effects on Blood Glucose of Ethyl Acetate-Butanol Fraction of Dialium guineense Aqueous Leaf Extract (Cesalpiniaceae)
Authors: Diatta Charlot , Diassy Henry , Barboza Firmin Sylva , Ball Fatimata Seydy , Camara Mariama , Gassama Abdoulaye , Yoro S. Y. Guata 
Published: December 2022

Introduction: The overall objective of the study was to evaluate the effect on blood glucose of the ethyl acetate-butanol fraction (EABF) compounds of the aqueous leaf extract of Dialium guineense (Cesalpiniaceae).
Materials and Methods: The powder of D. guineense leaves was subjected to decoction. The aqueous solution was respectively fractionated with ethyl acetate and butanol. The sub-fractions were grouped to form the ethyl acetate-butanol fraction (EABF), enriched in flavonoids and tannins. The condensed tannins of EABF were eliminated under the action of casein, resulting in a condensed tannin-free fraction (EAB-TFF). EABF and EAB-TFF were phytochemically characterized and tested in normo-glycemic rats, a glucose tolerance test and type 2 diabetic rats.
Results, Analysis and Discussion: EABF (300 mg/kg, per os) has no significant effect on blood glucose in normo-glycemic rats (0.80±0.12 vs 0.81±0.01 g/L). Under the same conditions, EABF without tannins (EAB-TFF: 300 mg/kg, per os) is hypoglycemic (0.57±0.05 vs 0.82±0.05 g/L). These results suggest the existence of an antagonism, in the effects on blood glucose, between tannins and probably flavonoid-like compounds. In type 2 diabetic rats, the daily administration of EABF (300 mg/kg/day, per os) varied blood glucose from 2.73±0.39 to 1.14±0.58 g/L (n=5, p<0.05). Similar effects were observed with EAB-TFF (300 mg/kg/day, per os), administered under the same conditions (1.12±0.04 g/L vs 3.01±0.5 g/L) (p<0.05, n=5). EABF has no effect on blood glucose in normo-glycemic rats, whereas under the same conditions, EAB-TFF induces an hypoglycemic effect. These results suggest the existence of compounds acting in opposite directions, in the regulation of blood glucose.
Plasma Kinins- A Pharmacological Perspective
Authors: G. Jefry Winner , N. Anusha 
Published: December 2022

Background: Plasma kinins are known for decades but the understanding of them is not up-to the mark and the complexity is the reason. There are many drugs and trials undertaken with these as drug targets but only very few have been successfully marketed and used. Rest all others have resulted in failure during various phases of the trial.
Purpose: The purpose of this review is to explain and explore the complexity of plasma kinins and explore the relations between Kinins, and analyze the failures in drug development with these receptors as targets.
Implication: This extensive review might help in understanding the complexity and ensure the reduction of drug development failures in these molecules as drug targets
Conclusion: Kinins have an important role in the homeostatic functions of the body physiologically. The pathophysiological roles in inflammation are also known. The complexity of these systems is well established.
Laodike (Laodice), wife of Antiochos II
Authors: Mittag Peter 
Published: December 2022

Abstract
Laodike fought after the death of her husband, Antiochos II, against his second wife Berenike (Third Syrian War or Laodicean War). After Berenike and her son had been eliminated, Laodike seems to have forced her son Seleukos II to accept his little brother Antiochos Hierax as co‐regent. The circumstances of her death are unknown.
Caucasus mountain
Authors: Cojocaru Victor 
Published: December 2022

AbstractThe mountains between the Black and Caspian seas were not only a land of famous mythological heroes but also a very important crossroad of civilizations. Set between Greeks and Persians, Romans and Parthians/Sasanians, and connected to “history‐makers” such as Alexander the Great and Pompey, the Caucasus, with all its associations, played a great role on the stage of Eurasian antiquity.
Constantinople, history and monuments
Authors: Bassett Sarah E. 
Published: December 2022

Abstract

Located on a hilly peninsula at the confluence of the Golden Horn, the Sea of Marmora, and the Bosphorus, Constantinople covered approximately 14 sq km at its largest extent and was among the most impressive cities of the later Roman world. This entry outlines the city's development from its initial settlement as a Greek colonial outpost in the seventh century
bce
through its Late Antique heyday. Three major phases define this development: Byzantion (seventh century
bce
to second century
ce
), Colonia Antonina (second to fourth century
ce
) and, finally, New Rome or Constantinople (fourth to seventh century
ce
).
Agonistic Festivals, Roman Empire
Authors: van Nijf Onno M. 
Published: December 2022

AbstractAgonistic festivals flourished in the Roman period. Building on an old Greek tradition, they constituted an empire‐wide network. They were closely bound up with social, cultural and political life at local levels, where they served the self‐presentation of cities and their ruling elites. Festivals also played a part in spreading the imperial message. They remained a popular feature of life until Late Antiquity when the agonistic festivals disappear for a variety of reasons.
Mētropoleis
Authors: Tangaro Nicoletta 
Published: December 2022

AbstractThe Greek termmētropolis, literally “mother city,” was first used to express the relationship between a founding city and its colony during the Greek colonization of the western Mediterranean in the eighth centurybce. Under the Roman Empire it came to be a title granted to cities by the emperor. It could be purely honorific or it could imply privileges such as remission of taxes, the promotion of athletic and cultural competition, or a dominant role within the organization of the imperial cult on the provincial level.
Athens, Late Antique and Early Byzantine
Authors: Deligiannakis Georgios 
Published: December 2022

Abstract
Late Antique Athens, like Roman Athens before it, remained a prosperous university city, renowned for its rhetorical and philosophical schools and its antiquities. Justinian I shut down the Athenian Neoplatonic school in 529, which was by that time only intended for uncompromising pagans. The city shrank a great deal in the seventh century, but it remained an important regional centre and a pilgrimage site.
Frequency of errors in the transfer of treatment parameters from the treatment planning system to the oncology information system in a multi‐vendor environment
Authors: Donahue William P. , Draeger Emily , Han Dae Yup , Chen Zhe 
Published: December 2022

AbstractBackgroundTechnological advancements have made it possible to improve patient outcomes in radiotherapy, sparing both normal tissues and increasing tumour control. However, these advancements have resulted in an increase in the number of software systems used, which each require data inputs to function. For institutions with multiple vendors for their treatment planning systems and oncology information systems, the transfer of data between them is potentially error prone and can lead to treatment errors.PurposeThe goal of this work was to determine the frequency of errors in data transfers between the Varian Eclipse treatment planning system and the Elekta Mosaiq oncology information system.MethodsAn in‐house program was used to quantify the number of errors for 2700 unique plans over an 8‐month period. Using this information, the frequency of the errors were calculated. A risk priority number was calculated using the calculated frequencies to determine the impact on the clinic.ResultsThe most common errors discovered were backup timer settings (10.7%), Field label (8.5%), DRR associations (3.3%), imaging field types (3.1%), dose rate (1%), Field Id (0.8%), imaging isocenter (0.7% and SSD (0.7%). Based on the risk priority numbers, the DRR association error was ranked as having the highest potential impact on the patient.ConclusionsThe results of the work show that the most effort should be focused on checking the manual steps performed in the transfer process, while items that are imported directly from DICOM‐RT without modification are highly likely to be transferred accurately. The data can be used to help guide the implementation of future automated tools and process improvement in the clinic.
Association between collaterals, cerebral circulation time and outcome after thrombectomy of stroke
Authors: Wang Ying‐Jia , Wang Jia‐Qi , Qiu Jin , Li Wei , Sun Xian‐Hui , Zhao Yong‐Gang , Liu Xin , Zhao Zi‐Ai , Liu Liang , Nguyen Thanh N. , Chen Hui‐Sheng 
Published: December 2022

AbstractObjectiveCerebral circulation time (CCT) and collateral score (CS) are associated with functional outcomes in acute ischemic stroke (AIS) patients after endovascular treatment (EVT), and may be related to each other. We aim to determine the relationship between CS and CCT on functional outcomes.MethodsWe retrospectively enrolled consecutive patients with anterior circulation large vessel occlusion (LVO) AIS who received EVT. CS and CCT were measured based on digital subtraction angiography (DSA). We defined CS 0–2 and 3–4 as poor and good collateral status, respectively, and used change of CCT (cCCT), which was defined as the change of stroke side CCT (sCCT) versus healthy side CCT (hCCT). Mediating analysis was used to evaluate the influence of cCCT on the association between CS and functional outcomes, and ROC curves were further used to explore the predictive ability of the interaction between cCCT and CS for functional outcomes.ResultsA total of 100 patients were enrolled in the final analysis. A higher cCCT (r = −0.239; p = 0.017) was associated with lower CS, and cCCT mediated the association of CS with functional outcome. Logistic regression analysis found that CS, cCCT and cCCT‐CS interactions were independently associated with functional outcome, and cCCT‐CS interaction has better predictive performance, with a higher area under curve value than CS or cCCT alone (0.79 vs. 0.75 or 0.75).InterpretationTo our knowledge, this study provides the first report of the association of collateral status with cCCT, and their interaction effect on functional outcome in AIS‐LVO patients receiving EVT.
Adaptive time‐varying formation control for teleoperation system: A finite‐time approach
Authors: Su Shan , Ji Yude 
Published: December 2022

SummaryIn this article, the finite‐time formation control scheme is put forward for teleoperation system with time delay. First, a group of finite‐time observers are established to address the teleoperation system with time‐varying delay issue and via linearly parameterize to deal with the uncertainty in the system. The theory of self‐stable domain (SSR) is then applied to provide sufficient circumstances for the observers error dynamics to converge in finite‐time. Then, in line with the estimation of time delay derivatives to reconstruct the regression matrix as well as the adaptive law, the observer based time‐varying formation control protocol is drawn up. On the basis of finite‐time state‐independent input‐to‐output practical stable (FTSIIOpS) theorem, sufficient conditions for teleoperation implement time‐varying formation are developed. Finally, simulation is being used to validate the efficiency of the proposed strategy.