bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of Gingival Crevicular Fluid and Serum Tartrate-resistant Acid Phosphatase Levels in Subjects with Clinically Healthy Periodontium and Chronic Periodontitis – A Clinico-biochemical Study
Authors: Baddam Harshitha , Vivekanandan Gopinath , Kondreddy Kameswari , Peddi Swapna , Chitnis Pranjal Praveen , Singh Yash Pal , Tiwar Rahul V. C. 
Published: February 2023

Background:
Periodontitis is a chronic inflammatory disease with conglomerate etiology making it difficult to diagnose at the early stages. Potential biomarkers in gingival crevicular fluid (GCF) would determine the presence of the current disease activity, predict sites vulnerable for future breakdown, and assess the response to periodontal interventions. Merely elevated levels of inflammatory soft-tissue markers do not indicate bone destruction. Since there is no single ideal biomarker established, bone-related biomarkers such as telopeptide of type I collagen, osteocalcin, calprotectin, osteopontin, and tartrate-resistant acid phosphatase (TRAP) seem to hold great promise as predictive markers to determine bone destruction and active phases in the disease progression. The present study is intended to explore the biologic plausibility of the levels of TRAP in health and chronic periodontitis.

Materials and Methods:
The present cross-sectional clinico-biochemical study comprised 30 systemically healthy subjects with 15 periodontally healthy and 15 chronic periodontitis subjects who were age and gender matched. GCF and blood samples were collected from all the patients. TRAP estimation was done in both the samples using an enzyme-linked immunosorbent assay kit. The data were analyzed using independent t-test and Pearson correlation test.

Results:
Serum and GCF TRAP levels in chronic periodontitis subjects were significantly higher when compared to the periodontally healthy group. There were no significant correlations found among serum and GCF TRAP levels with increasing age and gender in both the groups. An increase in disease severity, i.e., increase in probing pocket depth and clinical attachment level, did not show correlation with the GCF and serum TRAP levels in the chronic periodontitis group.

Conclusion:
Based on the findings of the present study, increased GCF TRAP levels in chronic periodontitis seem to be a potential marker for identifying ongoing periodontal destruction.
Antimicrobial Activities of the Soft-Tissue Ethanolic Crude Extracts of Corbiculid Clam, Corbicula Fluminea and Cyrenid Clam, Geloina Expansa
Authors: De Guzman Marco F. , T. Argente Francis Albert 
Published: February 2023

Objective:
The emergence of new infectious diseases and the increased in bacterial resistance to diseases have led to the search for potential sources of antimicrobials. Bivalves have been found to possess bioactive compounds that have tremendous potential in medical science. Corbicula
fluminea and Geloina expansa are bivalves that can survive in extreme environmental conditions and are surrounded by various microbes; these may have facilitated the potential production of different bioactive compounds with unique features to protect against pathogenic microorganisms.

Materials and Methods:
Antimicrobial activity of various concentrations of the ethanolic crude extracts (ECEs) of C.
fluminea and G.
expansa were tested against bacteria and fungi using the standard disk diffusion technique. There were three bacteria used in the antibacterial assay, namely Escherichia
coli (Gram-negative), Pseudomonas
aeruginosa (Gram-negative bacteria), Staphylococcus aureus (Gram-positive), and for antifungal assay, the fungi, Candida
albicans, and Aspergillus
niger were used.

Results:
The ECEs of C.
fluminea showed 12.67-h activity on E. coli with an inhibition zone (IZ) range of 10–12.8 mm and for G.
expansa showed an IZ range of 9.6–14.4 mm. A similar IZ range for C.
fluminea (10.6–12.4 mm) and G.
expansa (9.8–13.6 mm) was observed in P.
aeruginosa with an efficacy time of 14 h and 17.3, respectively. S.
aureus test cultures also showed activity of C.
fluminea ECEs with an IZ range of 0.00–17 mm and efficacy time of 15 h, while G.
expansa showed a mean of 15.6 mm. The two fungal strains tested showed activity of C.
fluminea, and G.
expansa ECEs, an IZ range of 8.3–12.2 mm was observed in A.
niger while C.
albicans showed activity with an IZ range of 9.6–12.8 mm. The ECE's concentrations of 50 and 100 mg/ml of C.
fluminea and G.
expansa showed a significantly higher result than positive control against P.
aerigunosa.

Conclusions:
The study showed that C.
fluminea and G.
expansa are potential sources of antimicrobial compounds. Identification, extraction, and purification of such compounds are recommended for future studies.
Determinación de coeficiente foliar para la vainilla (Vanilla sp.) y la papa china [Colocasia esculenta (L.) Schott]
Authors: Acosta Iglesias Dagoberto , Yaguache Camacho Bélgica D. , Gutiérrez Morales Eberto P. 
Published: February 2023

El resultado principal obtenido, se basa en la determinación de un coeficiente foliar para cada una de dos especies de plantas de interés para la investigación, la vainilla (Vanilla sp.) y la papa china [Colocasia esculenta (L.) Schott]. El procedimiento seguido consiste en considerar una cantidad adecuada de nodos, tomando las medidas en un sistema de coordenadas rectangulares, ubicada la hoja de forma conveniente, a partir de los cuales se construye utilizando una modificación de la interpolación segmentada de segundo orden, que considera la condición sobre la segunda derivada, en lugar de la primera, con el propósito de modelar el borde de la hoja conservando la intensidad con la que se curva, identificada con la concavidad. Construido el borde de la hoja, se calcula el área que este encierra y se compara con la de un rectángulo que la contiene de forma inscrita, para determinar el coeficiente foliar que pueda ser utilizado en estudios sobre procesos de fotosíntesis en la planta. Son utilizadas dos modalidades de hojas para este fin, las hojas medidas experimentalmente y otro conjunto de hojas, generadas de forma artificial y proporcional, desde las de tamaño menor hasta las más grandes. Los cálculos se realizan con programas formulados en el Asistente Matemático Matlab.
Ժամանակի հայեցակարգի առանձնահատկությունները Ժան-Պոլ Սարտրի ‹‹Վերջին հնարավորություն›› վեպ-կինոսցենարում
Authors: Մայիլյան Ալվարդ 
Published: February 2023

Հոդվածում վերլուծվում են դասական քրոնոտոպի փոխակերպումը Ժան-Պոլ Սարտրի ‹‹Վերջին հնարավորություն›› վեպ-կինոսցենարում, տարածաժամանակային հայեցակարգի նոր դրսևորումները հերոսների հիշողությունների և հանդերձյալ կյանքի պատկերման միջոցով:
Ուսումնասիրվում են քրոնոտոպի նոր դրսևորումները հերոսների հիշողությունների, երևակայության և համակերպման միջոցով, ինչպես նաև կրկնակի քրոնոտոպի հնարը, ֆանտաստիկ էլեմենտների ներմուծումը տեքստ՝ որպես հեղինակի փիլիսոփայական հայացքների մեկնություն:
Knowledge & Attitude regarding Stem Cells research and its applications among Residents of a Tertiary Care Hospital in Karachi, Pakistan
Authors: Ambreen Unar  , Syed Akbar Abbas  , Abdul Basit Shah Vardag  , Soubia Akhtar  , Ozair Awan  , Ainulakbar Mughal  
Published: February 2023

Objective: The importance and potential of the use of stem cells as therapeutic tools is enormous and therefore, health professionals should be expected to have thorough knowledge and a positive attitude towards their utilization in medical practice. Hence this study was carried out to report and assess the knowledge and attitude regarding stem cell in our region.
Methodology: The study was conducted amongst the residents employed at the Aga Khan University hospital, Karachi Pakistan from September-October 2022 with a sample size of 57.
Results: Amongst our survey participants, 33 (54.2%) responded with a score of 48 and above (i.e., 60% or above); 25 (40.9%) of the study participants scored between 50-60% only 3 (4.9%) had a score 40-50%
Conclusion: Our survey shows a reasonable level of knowledge of the generic principles and implications Stem cell therapy amongst the residents
Keywords: Stem cell, Head and Neck, Risk, Cell, Tissue, Therapy
Mesenchymal stem cells and its translation into clinical orthodontics: current trends and future perspectives
Authors: Aqeel Ahmed  , Hafsa Qabool  , Saqib Habib  , Mubassar Fida  , Syeda Gul Rukh Shah  
Published: February 2023

Oral mesenchymal stem cell populations in humans have been discovered in close vicinity to oral mucosal tissues and both primary (deciduous) and secondary (permanent) teeth. All these different kinds of stem cells have the ability to divide and replenish themselves, however they vary in their gene expression profiles and their capacity to give rise to distinct cell lineages. They all have multipotentiality i.e. chondrogenic, osteogenic, adipogenic, and neurogenic. Due to their relative accessibility, these cell types may form a source of stem cells with substantial potential for application in tissue regeneration. In this review, discoveries outlining stem cell potential are discussed on various aspects as, are their various applications in orthodontics i.e. orthodontic tooth movement, fixing external root resorption, correcting craniofacial anomalies, accelerating craniofacial distraction osteogenesis, recreating the TMJ, and ensuring a stable maxillary expansion.
Keywords: Cell, Osteogenesis, Transcriptome, Orthodontics, Stem Cells, Membrane, Temporomandibular
Aplikasi Pendeteksi Dini Kanker Serviks Berbasis Android
Authors: B Herlinah , Husain Nursuci Putri 
Published: February 2023

Kanker serviks merupakan pertumbuhan dari suatu kelompok sel yang tidak normal pada serviks (mulut rahim). Minimnya pengetahuan mendiagnosa yang dimiliki wanita terhadap kanker serviks sekitar 60% - 77%. Kurangnya pengetahuan diagnosa tentang gejala kanker serviks sehingga banyak perempuan tidak mengetahui gejala kanker serviks dan memiliki dua kemungkinan apakah itu gejala kanker serviks atau gejala penyakit lainnya. Tujuan penelitian merancang aplikasi pendeteksi dini kanker serviks berbasis android guna memantau secara dini penyakit kanker serviks dalam membantu perempuan mendiagnosa secara mandiri. Metode penelitian R&D (Research and Development) berfungsi menghasilkan, mengembangkan serta menguji keefektifan produk (aplikasi pendeteksi dini kanker serviks berbasis android) dan metode forward chaining berfungsi dalam pengambilan keputusan berdasarkan fakta yang di input sehingga menghasilkan kesimpulan. Hasil pengujian aplikasi terdapat 4 menu utama yaitu menu home, diagnosa, hasil diagnosa serta profil, dimulai dengan pengguna mengklik menu diagnosa dalam memilih gejala yang dialaminya, kemudian pengguna mengklik menu hasil diagnosa untuk melihat hasil dari gejala yang telah diagnosanya dan memiliki 4 kriteria yaitu kanker serviks stadium 1, kanker serviks stadium 2, kanker serviks stadium 3 dan kanker serviks stadium 4. Kesimpulan aplikasi dimana fungsional input dan output berjalan dengan dengan baik sesuai dengan konsep dasar yang telah dibuat serta dapat diimplementasikan.
INFLUÊNCIA DE PLANTAS MEDICINAIS E FITOTERÁPICOS DURANTE A PANDEMIA DA COVID-19
Authors: Da Silva Neto Jerônimo Gregório , Lopes Fernandes Maria do Socorro , Teles Rocha Francisco Vinicius , De Araújo Costa Santos Mirelly Suenha , Dos Reis Silva Ana Lourdes , Claudino Rodrigues Maria do Desterro , Freitas Santos José Augusto , Marques Luana da Conceição , Sousa da Costa Oliveira Naisa Marta , De França Rocha Alane 
Published: February 2023

O coronavírus-2019, conhecido como COVID-19 é uma doença respiratória causada pelo vírus SARS-CoV-2. Os seres humanos não possuíam uma imunidade protetora para o novo coronavírus SARS-CoV-2, o que fez com que a população optasse por vários meios de prevenção e tratamento da doença, a mais comum foi o uso de plantas medicinais e fitoterápicos. Este estudo teve como objetivo verificar a influência de plantas medicinais e fitoterápicos durante a pandemia da COVID-19. Realizou-se uma revisão integrativa. A busca dos artigos foi realizada nas bases de dados PubMed, Scielo, Lilacs, por meio dos descritores nos idiomas português e inglês: “Plantas Medicinais”, “Fitoterápicos” e “COVID-19‘”; “Medicinal Plants”, “Phytotherapics” and “COVID-19'” unidos com o operador booleano “AND". O acesso às bases de dados foi realizado no período de setembro a outubro de 2022. Foram encontrados 185 artigos e após a aplicação dos critérios de inclusão, restaram 6 artigos. Percebeu-se que durante a pandemia de COVID-19, foi detectado que as pessoas diminuíram o consumo de plantas medicinais, enquanto 60,6% mantiveram e 27,0% aumentaram o consumo. Enquanto para produtos fitoterápicos, houve diminuição de 16,4%, manutenção de 61,7% e aumento do uso em 21,9%. O aumento observado pode estar relacionado com a necessidade em manter o sistema imunológico saudável, visando evitar a contaminação pelo vírus do SARS-COV 2.
Cost Analysis for the Management of Acute Coronary Syndrome using Different Quality of Care Indicators
Authors: Tumanan-Mendoza Bernadette A. , Mendoza Victor L. , Morales Dante D. 
Published: February 2023

Objective. This study determined the economic burden for nonfatal uncomplicated acute coronary syndrome (ACS) using 100% compliance to certain a) non-invasive or b) invasive and non-invasive diagnostic and therapeutic interventions with class I recommendations in the American College of CardiologyAmerican Heart Association (ACC-AHA) clinical practice guidelines for ACS in three tertiary hospitals using the societal perspective. It also determined the costs using the patient’s perspective in the setting of one private tertiary hospital.
Methods. This study was a cost analysis that included a) costs of patient’s resources, b) production losses, and c) costs of other resources or sectors, from hospitalization to one month postdischarge for ACS. Several models were constructed due to variations in the costs of diagnostic and therapeutic interventions in the three settings.
Results. Using the societal perspective, one model for noninvasive options yielded the following (costs as of January 31, 2009): hospital A, Php87,014 - 124,799; hospital B, Php75,592 - 96,072; hospital C, Php71,969 - 92,148. Excluding fibrinolytic therapy, the lowest total cost would be Php65,000. However, if coronary angiography was added to the models for hospital C, the cost was Php107,154 - 134,574 (coronary angiography was not available in hospitals A and B). Using the patient’s perspective, theadjusted mean cost for the model which used the least expensive medication was Php96,421 (Standard Deviation = 34,076).
Conclusion. The economic burden for nonfatal uncomplicated ACS may range from Php65,000 - 134,574.
Creating Space for Shakespeare
Authors: Mackenzie Rowan 
Published: February 2023

Applied Shakespeare is attracting growing interest from practitioners and academics alike, all keen to understand the ways in which performing his works can offer opportunities for reflection, transformation, dialogue regarding social justice, and challenging of perceived limitations. This book adds a new dimension to the field by taking an interdisciplinary approach to topics which have traditionally been studied individually, examining the communication opportunities Shakespeare’s work can offer for a range of marginalised people.
It draws on a diverse range of projects from across the globe, many of which the author has facilitated or been directly involved with, including those with incarcerated people, people with mental health issues, learning disabilities and who have experienced homelessness. As this book evidences, Shakespeare can be used to alter the spatial constraints of people who feel imprisoned, whether literally or metaphorically, enabling them to speak and to be heard in ways which may previously have been elusive or unattainable.
The book examines the use of trauma-informed principles to explore the ways in which consistency, longevity, trust and collaboration enable the development of resilience, positive autonomy and communication skills. It explores this phenomenon of creating space for people to find their own way of expressing themselves in a way that mainstream society can understand, whilst also challenging society to ‘see better’ and to hear better. This is not a process of social homogenisation but of encouraging positive interactions and removing the stigma of marginalisation.
The Information State in England
Authors: Higgs Edward 
Published: February 2023

Is the official collection of information on individuals inevitably leading to the creation of a 'Big Brother State'? In this innovative interdisciplinary study, Edward Higgs takes issue with writers such as Michel Foucault and Anthony Giddens who argue that state information gathering can be seen in terms of an expansion towards modernity, and as social control. Using ground-breaking historical research, Higgs reveals that, since 1500, the English state has always been an Information State although the nature of that state has changed markedly over the last 500 years. In its modern form, the Information State is as much about winning consent via the provision of benefits as repression in the interests of elites.
The Information State in England
- Draws upon a wide range of sociological theory and historical research, as well as evidence gathered from archival sources
- Challenges many assumptions about state formation and the role of information
- Views the development of the state in terms of the changing balance between decentralized and centralized forms of governance
- Provides a critique of sociological and postmodernist concepts of modernity
Witchcraft and Magic in Sixteenth- and Seventeenth-Century Europe
Authors: Scarre Geoffrey , Callow John 
Published: February 2023

The figure of the witch still has the ability to exert a powerful fascination on the modern mind. The vision of the elderly crone begging for charity at the crossroads, an object of fear and revulsion for her local community, has combined with the memory of prolonged judicial persecution and oppression to inspire contemporary movements as far removed from each other as Wiccans and women’s liberation. In tackling such an emotive issue, where misogyny and violence combine with superstition and the basest of human instincts, Scarre and Callow chart a clear and refreshingly level-headed approach to the subject. Distinguishing between fact and fiction, they set the witch trials firnly back within the context of their own times and, without seeking to exonerate those responsible, demonstrate how it was possible for judiciaries and social elites to believe wholeheartedly in the reality and efficacy of witchcraft as a valid system of belief and as a dangerous threat to the fabric of society in which they lived.
This new edition has been comprehensively updated to take account of the vast expansion in interest and scholarly research that has taken place in the field since the publication of the first edition. This work provides a provocative thesis for those seeking to understand the basis for the politics of persecution and a firm interpretative basis around which further exploratory research may be conducted.
Learning with the Labyrinth
Authors: Sellers Jan , Moss Bernard 
Published: February 2023

This book discusses the theory and practice of labyrinth creation and use. From issues of design and cost, to how a labyrinth may be used as a university-wide resource and also be used for outreach to the wider community, it covers labyrinth use:
– Within disciplines, such as initiatives to deepen reflection and explore contemplative approaches to learning
– In wider university contexts, such as counselling; chaplaincy; learning and educational development; widening participation and student transition
– Across the whole university, and reaching out to the wider community of which the university is a part, from the labyrinth as a conference resource (as well as topic), to festival contributions.
Learning with the Labyrinth seeks to illustrate, inspire and share ideas that can be taken further by the reader.
Situating Data
Authors: Es Karin , Verhoeff Nanna 
Published: February 2023

Taking up the challenges of the datafication of culture, as well as of the scholarship of cultural inquiry itself, this collection contributes to the critical debate about data and algorithms. How can we understand the quality and significance of current socio-technical transformations that result from datafication and algorithmization? How can we explore the changing conditions and contours for living within such new and changing frameworks? How can, or should we, think and act within, but also in response to these conditions?
This collection brings together various perspectives on the datafication and algorithmization of culture from debates and disciplines within the field of cultural inquiry, specifically (new) media studies, game studies, urban studies, screen studies, and gender and postcolonial studies. It proposes conceptual and methodological directions for exploring where, when, and how data and algorithms (re)shape cultural practices, create (in)justice, and (co)produce knowledge.
Pemberdayaan Pemuda melalui Sanggar Tari dan Hombo Batu sebagai Upaya Pelestarian Budaya di Desa Hilizihono Kecamatan Fanayama Kabupaten Nias Selatan
Authors: Zalukhu Merri Christina 
Published: February 2023

Seiring dengan pesatnya perkembangan teknologi, beberapa tradisi dan budaya masyarakat desa mulai berubah termasuk di daerah-daerah di kepulauan Nias. Hal ini tentunya mempengaruhi adat istiadat masyarakat setempat khususnya pada masyarakat Desa Hilizihono. Oleh karena itu, Ormawa HMPS Pendidikan Bahasa dan Sastra Indonesia STKIP Nias Selatan memandang perlu menggagas sebuah program sebagai upaya penanganan dan pelestarian budaya. Program ini merupakan kegiatan yang diselenggarakan dan didanai Oleh DitjenBelmawa Kemendikbudristek. Tim Kegiatan ini beranggotakan 11 orang mahasiswa yang diketuai oleh Redilius Laia dan didampingi oleh Ibu Merri Christina Zalukhu, M.Pd. sebagai dosen Pendamping. Masyarakat sasaran program ini adalah pemuda/i desa Hilizihono. Tujuan dari program ini antara lain 1) sebagai upaya untuk melestarikan adat atau kebudayaan di desa Hilizihono; 2) membantu memberdayakan masyarakat desa Hilizihono dan mengembangkan potensi seni khususnya pemuda; 3)membantu terbentuknya sanggar seni dan budaya di Hilizihono dengan melengkapi peralatan tari untuk seterusnya dapat dijadikan wadah berkreasi; dan 4)membantu mengatasi permasalahan kemampuan menari dengan mengadakan pelatihan dengan mendatangkan ahli. Metode pelaksanaan kegiatan yang telah dilakukan ditempuh dengan tiga cara yakni tahap persiapan, pelaksanaan, dan evaluasi program. Ketercapaian program tampak pada peningkatan pengetahuan para pemuda di Desa Hilizihono; terbentuknya pengurus sanggar seni budaya “Sofu Zato”; pelatihan tari selama 12 kali; diadakannya atraksi budaya; dan terimplementasinya mata kuliah Kebudayaan dan Pariwisata Nias melalui program ini. Luaran yang dicapai adalah buku pedoman praktis menari; profil dan poster; video kegiatan; publikasi pada media sosial dan massa, jurnal, dan keberlanjutan program. Dapat disimpulkan bahwa program ini berhasil memberdayakan pemuda desa Hilizihono dalam melestarikan dan mengembangkan kebudayaan Nias Selatan. Disarankan agar kegiatan ini tetap dilanjutkan oleh masyarakat khususnya para pengurus dan anggota sanggar.