bluuebunny/crossref_metadata_2025_split huggingface dataset:
ZC3H11A mutations cause high myopia by triggering PI3K-AKT and NF-κB mediated signaling pathway in humans and mice
Authors: Chen Chong , Liu Qian , Tang Cheng , Rong Yu , Zhao Xinyi , Li Dandan , Lu Fan , Qu Jia , Liu Xinting 
Published: August 2023

AbstractHigh myopia (HM) is a severe form of refractive error that results in irreversible visual impairment and even blindness. However, the genetic and pathological mechanisms underlying this condition are not yet fully understood. From a adolescents myopia survey cohort of 1015 HM patients, pathogenic missense mutations were identified in theZC3H11Agene in four patients by whole exome sequencing. This gene is a zinc finger and stress-induced protein that plays a significant role in regulating nuclear mRNA export. To better understand the function and molecular pathogenesis of myopia in relation to gene mutations, aZc3h11aknock-out (KO) mouse model was created. The heterozygous KO (Het-KO) mice exhibited significant shifts in vision towards myopia. Electroretinography revealed that the b-wave amplitude was significantly lower in these mice under dark adaptation. Using immunofluorescence antibodies against specific retinal cell types, the density of bipolar cell-labelled proteins was found to be decreased. Transmission electron microscopy findings suggesting ultrastructural abnormalities of the retina and sclera. Retinal transcriptome sequencing showed that 769 genes were differentially expressed, andZc3h11awas found to have a negative impact on the PI3K-AKT and NF-κB signaling pathways by quantitative PCR and western blotting. In addition, myopia-related factors, including TGF-β1, MMP-2 and IL-6 were found to be upregulated in the retina or sclera. In summary, this study characterized a new candidate pathogenic gene associated with high myopia, and indicated that theZC3H11Aprotein may serve as a stress-induced nuclear response trigger, and its abnormality causes disturbances in a series of inflammatory and myopic factors. These findings offer potential therapeutic intervention targets for controlling the development of HM.
Influence of Diabetes Mellitus Type 2 on the angiogenic potential of Bone Marrow derived Mesenchymal Stem Cells
Authors: Adwan Sofia , Hammad Hana , Ahram Mamoun , Awidi Abdalla 
Published: August 2023

ABSTRACTMesenchymal stem cells (MSCs) are used as novel therapeutic tools in cell-based therapies including diabetic complications. However, diabetes may negatively affect the therapeutic potential of autologous MSCs. In order to enhance the utilization of diabetic MSCs, better characterization of their angiogenic capacity should be performed. The aim of this study was to investigate the effect of diabetes mellitus (DM) on the angiogenic potential of bone marrow derived MSCs. MSCs were isolated from DM subjects and were compared with MSCs isolated from non-DM subjects. The angiogenic potential of MSCs was assessed in which there was insignificant difference in the proliferation and expression of angiogenic factors between the two groups. Moreover, no statistically significant change was found in the viability and angiogenic activities of endothelial cells isolated from both groups. Results indicate that the hyperglycemic milieu had no significant impact on the angiogenic-related functional properties of MSCs and they are able to survive the harsh diabetic conditions.
Does crop insurance attenuate farm financial risk?
Authors: Regmi Madhav , Featherstone Allen M. , Tack Jesse 
Published: August 2023

PurposeFederally subsidized crop insurance aims to mitigate farm risks of crop producers. A body of literature has examined informational problems under this program. However, few studies empirically link crop insurance participation with farm financial performance. Most use county-level aggregates to argue that crop insurance participation is associated with increased farm financial debt. Using farm-level data, this study provides empirical evidence of crop insurance's effects on farm financial risk.Design/methodology/approachThe impact of crop insurance on farm financial risks is assessed using farm-level data from Kansas. The sample consists of at least 1,600 farms each year from 2002 to 2015. Financial risks are measured using the probability of falling into the critical zone of five different financial ratios. The study uses two matching estimators to estimate the causal effects of crop insurance participation on farm financial risks. Several alternative empirical approaches account for unobserved heterogeneity and potential endogeneity.FindingsCrop insurance participation has reduced the farm's likelihood of being in the critical liquidity risk by 8%. This result is robust across matching estimators and alternative specifications to account for unobserved heterogeneity and potential endogeneity.Originality/valueThis is one of the few studies to examine whether crop insurance reduces farm financial risks. This study provides empirical evidence of the extent to which crop insurance enrollment impacts farm financial risks. Findings suggest that crop insurance is critical to maintaining the financial well-being of crop producers, and significantly reduces the likelihood of producers being in a critical liquidity risk.
Automatic retrieval of health case reports for public needs using deep learning techniques
Authors: Liu Yi-Hung , Chen Sheng-Fong , Wen Dan-Wei (Marian) 
Published: August 2023

PurposeOnline medical repositories provide a platform for users to share information and dynamically access abundant electronic health data. It is important to determine whether case report information can assist the general public in appropriately managing their diseases. Therefore, this paper aims to introduce a novel deep learning-based method that allows non-professionals to make inquiries using ordinary vocabulary, retrieving the most relevant case reports for accurate and effective health information.Design/methodology/approachThe dataset of case reports was collected from both the patient-generated research network and the digital medical journal repository. To enhance the accuracy of obtaining relevant case reports, the authors propose a retrieval approach that combines BERT and BiLSTM methods. The authors identified representative health-related case reports and analyzed the retrieval performance, as well as user judgments.FindingsThis study aims to provide the necessary functionalities to deliver relevant health case reports based on input from ordinary terms. The proposed framework includes features for health management, user feedback acquisition and ranking by weights to obtain the most pertinent case reports.Originality/valueThis study contributes to health information systems by analyzing patients' experiences and treatments with the case report retrieval model. The results of this study can provide immense benefit to the general public who intend to find treatment decisions and experiences from relevant case reports.
Computations and measurements of the magnetic polarizability tensor characterisation of highly conducting and magnetic objects
Authors: Elgy James , Ledger Paul D. , Davidson John L. , Özdeğer Toykan , Peyton Anthony J. 
Published: August 2023

PurposeThe ability to characterise highly conducting objects, that may also be highly magnetic, by the complex symmetric rank–2 magnetic polarizability tensor (MPT) is important for metal detection applications including discriminating between threat and non-threat objects in security screening, identifying unexploded anti-personnel landmines and ordnance and identifying metals of high commercial value in scrap sorting. Many everyday non-threat items have both a large electrical conductivity and a magnetic behaviour, which, for sufficiently weak fields and the frequencies of interest, can be modelled by a high relative magnetic permeability. This paper aims to discuss the aforementioned idea.Design/methodology/approachThe numerical simulation of the MPT for everyday non-threat highly conducting magnetic objects over a broad range of frequencies is challenging due to the resulting thin skin depths. The authors address this by employing higher order edge finite element discretisations based on unstructured meshes of tetrahedral elements with the addition of thin layers of prismatic elements. Furthermore, computer aided design (CAD) geometrical models of the non-threat and threat object are often not available and, instead, the authors extract the geometrical features of an object from an imaging procedure.FindingsThe authors obtain accurate numerical MPT characterisations that are in close agreement with experimental measurements for realistic physical objects. The assessment of uncertainty shows the impact of geometrical and material parameter uncertainties on the computational results.Originality/valueThe authors present novel computations and measurements of MPT characterisations of realistic objects made of magnetic materials. A novel assessment of uncertainty in the numerical predictions of MPT characterisations for uncertain geometry and material parameters is included.
Quantitative calculation of electromagnetic scattering characteristics from drag plate of aircraft afterbody
Authors: Zhou Zeyang , Huang Jun 
Published: August 2023

PurposeThis paper aims to discuss the electromagnetic scattering characteristics of the afterbody model with two drag plates.Design/methodology/approachThe plane shape of the drag plate model is designed as a rectangle. High-precision unstructured grid technology is used to treat the target surface. A calculation method based on multiple tracking and dynamic scattering module is presented to calculate the radar cross section (RCS).FindingsThe results show that under the given observation conditions, the RCS and surface scattering characteristics of a single drag plate change with the increase of the opening angle, which makes the forward RCS of the afterbody model change more than 8.43 dBm2. The opening of two resistance plates at different fixed angles has little effect on the peak value and position of the RCS of the afterbody model. The dynamic deflection of the two drag plates can bring 16.78 dBm2 fluctuations to the forward RCS of the afterbody model, and more than 25.59 dBm2 fluctuations to the side RCS.Practical implicationsThe installation positions of the drag plate on the aircraft are various, so the method in this paper can provide reference and support for RCS analysis of the speed brake at other positions.Originality/valueThe presented calculation method is of engineering value to analyze the electromagnetic scattering characteristics of the drag plate.
Symmetry-breaking and trade in neoclassical economies with domestic policies having diminishing effect to production scale
Authors: Shinozaki Tsuyoshi , Tawada Makoto , Yanagihara Mitsuyoshi 
Published: August 2023

PurposeThe aim of this paper is to investigate whether a Nash equilibrium of a two-country trading economy is symmetry-breaking or not.Design/methodology/approachThe approach to tackle this topic is a theoretical treatment by the general equilibrium trade theory and game theory.FindingsIf each government's domestic policy serving private production is diminishing to the private production scale, the Nash equilibrium is not symmetry-breaking.Originality/valueIn the existing study of Chatterjee (2017), a similar result is derived by focusing on the properties of each country's GDP function. The authors, however, consider an economy where each country's PPF is strictly concave and show that the Nash equilibrium uniquely exists and this equilibrium is symmetry.
Foreign direct investment, technological transfer, employment generation and economic growth: new evidence from Ghana
Authors: Obeng-Amponsah William , Owusu Erasmus 
Published: August 2023

PurposeThis study examines the effect of foreign direct investment (FDI) on employment and economic growth in Ghana and examines the role of technology in these relationships.Design/methodology/approachThis study applied the autoregressive distributed lag (ARDL) bounds testing approach to cointegration and Granger causality tests to data from 1995 to 2017.FindingsBased on the empirical analysis, the key findings are as follows: FDI does not affect economic growth or employment in Ghana. However, technology moderates the relationship between FDI and economic growth and FDI and employment in the short run. The study also finds that technology exerts a positive effect on economic growth in both short and long run, whereas trade has a significantly negative effect on economic growth in Ghana.Research limitations/implicationsThe greatest constraint that faced the authors is the nonavailability of data,.Practical implicationsThe transfer of technology agreement enshrined in the GIPC Act should be made more robust and unambiguous, to make it a strict requirement for MNEs to be allowed to operate in Ghana. This increases Ghana's gains from FDI inflow.Social implicationsThe GIPC should tighten its monitoring regime so that MNEs do not exceed their expatriate employment quotas. This will ease the burden of unemployment among the youth in Ghana.Originality/valueThis study adds a new dimension to the literature on the impact of FDI on emerging economies by examining the role of technology in the association between FDI and growth, and FDI and employment.
Augmented reality in the metaverse market: the role of multimodal sensory interaction
Authors: Chen Chongyang , Zhang Kem Z.K. , Chu Zhaofang , Lee Matthew 
Published: August 2023

PurposeIn the growing information systems (IS) literature on metaverse, augmented reality (AR) technology is regarded as a cornerstone of the metaverse which enables interaction services. Interaction has been identified as a core technology characteristic of metaverse shopping environments. Based on previous human–technology interaction research, the authors further explicate interaction to be multimodal sensory. The purpose of this study is thus to better understand the unique nature of interaction in AR technology and highlight the technology's benefits for shopping in metaverse spaces.Design/methodology/approachAn experiment has been conducted to empirically examine the authors' research model. The authors use the structural equation modeling (SEM) approach to analyze the collected data.FindingsThis study conceptualizes image, motion and touchscreen interactions as the three dimensions of multimodal sensory interaction, which can reflect visual-, kinesthetic- and haptic-based sensation stimulation. The authors' findings show that multimodal sensory interaction of AR activates consumers' intention to purchase via a psychological process. To delineate this psychological process, the authors use feelings-as-information theory to posit that experiential factors can influence cognitive factors. More specifically, multimodal sensory interaction is shown to increase multisensory experience and spatial presence, which can effectively reduce product uncertainty and information overload. The two outcomes have been considered to be key issues in online shopping environments.Originality/valueThis study is one of the first ones that shed light on the multimodal sensory peculiarity of AR interactions in the extant IS literature. The authors further highlight the benefits of AR in addressing major online shopping concerns about product uncertainty and information overload, which are largely overlooked by prior research. This study uses feelings-as-information theory to explain the impacts of AR interactions, which reveal the essential role of the experiential process in sensory-enabling technologies. This study enriches the existing theoretical frameworks that mostly focus on the cognitive process. The authors' findings about AR interactions provide noteworthy guidelines for the design of metaverse environments and extend the authors' understanding of how the metaverse may bring benefits beyond traditional online shopping settings.
Facebook-based social media marketing and Facebook-based online purchases: evidence from the Facebook page admins of selected South Asian fashion retailers
Authors: Hosain Md Sajjad , Mamun Abdullah Mohammad Ahshanul 
Published: August 2023

PurposeThis study intends to explore the connection between Facebook-based social media marketing (FSMM) and Facebook-based online purchase order (FOPO) for 20 popular online fashion retail brands across three South Asian countries: India, Pakistan and Bangladesh. FSMM was further divided into four components: Perceived trust (PT), Perceived informativeness (PInf), Perceived interactivity (PInt) and Perceived benefit (PB). Design/methodology/approachThe authors selected 20 popular Facebook-based online fashion brands involved in clothing and fashion accessories businesses in those three countries. Later, the authors purposively selected 114 region-based Facebook page administrators (admins) responsible for operating those brands' Facebook pages and taking Facebook-based online orders. The authors collected primary data from those admins as respondents through a structured survey instrument. The authors applied SPSS 25 for descriptive analysis and a covariance-based structural equation modeling (CB-SEM) (through AMOS 25) for testing the hypothesized relations.FindingsBased on the valid responses and application of proper statistical measures, it was revealed that three FSMM components: PT, PInf and PB have significant positive relationships with FOPO, while PInt has an insignificant relationship with FOPO. Originality/valueSouth Asia is a growing business hub and the largest consumer market in terms of population. This study was conducted to identify the relationship between FSMM and FOPO in the three most prominent South Asian countries. As the first study was undertaken ever on customer perceptions of FSMM in a multi-country South Asian context, this paper is expected to be helpful for academics in conducting further empirical investigations on Facebook-based marketing as well as practitioners and policymakers in formulating and implementing Facebook-based marketing strategies.
Effect of curing media on the performance of clay bricks partially stabilised with pulverised cow bone ash
Authors: Edike Uche Emmanuel , Adenuga Olumide Afolarin , Idusuyi Daniel Uwumarogie , Oke Abdulkabir Adedamola 
Published: August 2023

Purpose
The purpose of this study is to advance the application of pulverised cow bone ash (PCBA) as a partial replacement of cement in soil stabilisation for the production of bricks. The study investigated the impact of PCBA substitution on the characteristic strength of clay bricks under variant curing media.

Design/methodology/approach
Dried cow bones were pulverised, and an energy-dispersive X-ray fluorescence test was conducted on PCBA samples to determine the chemical constituents and ascertain the pozzolanic characteristics. Ordinary Portland cement (OPC) and PCBA were blended at 100%, 75%, 50%, 25% and 0% of cement substitution by mass to stabilise lateritic clay at 10% total binder content for the production of bricks. The binder-to-lateritic clay matrixes were used to produce clay bricks and cylinders for compressive and splitting tensile strength tests, respectively.

Findings
The study found that PCBA and OPC have similar chemical compositions. The strength of the clay bricks increased with curing age, and the thermal curing of clay bricks positively impacted the strength development. The study established that PCBA is a suitable substitute for cement, up to 25% for stabilisation in clay brick production.

Practical implications
Construction stakeholders can successfully use a PCBA-OPC binder blend of 1:3 to stabilise clay at 10% total binder content for the production of bricks. The stabilised clay bricks should be cured at an elevated temperature of approximately 90°C for 48 h to achieve satisfactory performance.

Originality/value
The PCBA-OPC binder blend provides adequate soil stabilisation for the production of clay bricks and curing the clay bricks at elevated temperature. This aspect of the biomass/OPC binder blend has not been explored for brick production, and this is important for the reduction of the environmental impacts of cement production and waste from abattoirs.
Family entrepreneurship: a perspective article
Authors: Randerson Kathleen 
Published: August 2023

PurposeThe author synthesizes research at the genesis of the field of family entrepreneurship, allowing to distinguish it from the field of family business. Indeed, family entrepreneurship is at the intersection of family, entrepreneurship and family business and is dedicated to the understanding of entrepreneurial behaviors of family, family members and family businesses. Here, the author emphasizes the importance of context as well as bidirectional relationships to grasp the multiplicity of behaviors and their antecedents and outcomes. The author offers an overview of possible futures: how family entrepreneurship can be instrumental in understanding and taking action in face of ecological, economic and societal issues.Design/methodology/approachThe author synthesizes, critically assesses and integrates extant research, offering a state of the art of the field of family entrepreneurship accessible to a wide audience of readers.FindingsThe author reviews and integrates the literature that undergirds family entrepreneurship, flushing out its idiosyncratic value relative to family business. The author underscores how framing situations and issues with family entrepreneurship is a promising avenue to better understand and navigate pending ecological, economic and societal stakes.Originality/valueThis perspectives paper distinguishes family entrepreneurship from family business, the former building on and expanding the latter. It highlights how the augmented view is useful to understand entrepreneurial behaviors of families, family members and family businesses because it triangulates family, entrepreneurship and family business. Consequently, the present state of the art provides a useful synthesis and perspectives of possible futures. The originality of this research relies in offering a snapshot integrating prior research at the genesis of the field and demonstrating how the field can fruitfully support future research and practice, in particular to address grand challenges and wicked problems.