bluuebunny/crossref_metadata_2025_split huggingface dataset:
Refractory Congenital Chylous Ascites Successfully Treated with Sildenafil in a Premature Neonate: A Case Report and Review of The Literature
Authors: ACAR Filiz AKTÜRK , MUTLU Mehmet , ASLAN Yakup 
Published: July 2023

Abstract
Chylous ascites is a scarce disorder in the neonatal period caused by lymph leakage into the peritoneal cavity. It may develop congenitally or acquired. Here we report that a 30-week-old premature infant with congenital chylous ascites did not respond to various treatments, and there was a dramatic improvement with the addition of sildenafil. With this case report, we wanted to emphasize that sildenafil should be in the mind of the clinicians as a treatment option in the treatment of resistant chylous ascites.
Predictors of Cardiovascular and Bleeding Events in Patients on Antiplatelet and/or Anticoagulation with Myelodysplastic Disorders
Authors: Faieta Antonio 
Published: July 2023

Abstract
Antithrombotic therapy (ATT) in myelodysplastic syndromes (MDS)/chronic myelomonocytic leukemia (CMML) poses a unique clinical challenge due to the concomitant elevated bleeding, and thrombotic risk. In this paper, we performed a multiple variable analysis to find predictors of bleeding in patients with MDS in the setting of antithrombotic therapy.
Regulacje prawne dotyczące roślin genetycznie zmodyfikowanych w Unii Europejskiej
Authors: Lechowicz Katarzyna 
Published: July 2023

W ostatnich dwóch dekadach inżynieria genetyczna jest jedną z najszybciej rozwijających się gałęzi gospodarki. Wywołała jednocześnie burzliwą dyskusję wśród ekspertów z dziedziny ekologii, prawa, ekonomii, etyki i świata polityki. Zdaniem autora niezwykle dynamiczny postęp inżynierii genetycznej sprawia, że obowiązujące ramy prawne nie regulują precyzyjnie istotnych dla społeczeństwa zagadnień dotyczących GMO. W istniejących uwarunkowaniach pojawiają się zatem nowe wyzwania, do których należą: prowadzenie systematycznych i rzetelnych badań w zakresie wpływu GMO na człowieka i środowisko przyrodnicze oraz przyjęcie regulacji prawnych gwarantujących bezpieczeństwo zdrowotne społeczeństwa, a także wysoką jakość środowiska. W żadnym wypadku nie należy też ograniczać dostępu społeczeństwa do pełnej informacji o korzyściach i ewentualnych zagrożeniach stosowania GMO, ani zawężać swobody wyboru czy to produktów tradycyjnych czy też zmodyfikowanych
ВИЗНАЧЕННЯ ДИСТАНЦІЇ НИТЯНИМ ДАЛЕКОМІРОМ ІЗ ЗУМ-ТРАНСФОКАТОРОМ
Authors: ЧИЖ Ігор , ЛАЗАРЕНКО Карина 
Published: July 2023

В роботі наведені результати дослідження явища зсуву переднього фокусу зум-трансфокатора в нитяних далекомірах, пов’язаного із зміною кутового збільшення зум-афокальної системи. Показано, що ігнорування цього зсуву при розрахунках дальності може суттєво впливати на точність результату вимірювань. Розглянуто два типи зум-афокальних систем, що входять в систему зум-трансфокатора – двокомпонентної та чотирикомпонентної. Знайдено формулу переднього фокального відрізку трансфокатора з двокомпонентною афокальною системою. Викладено метод розрахунку переднього фокального відрізку трансфокатора з чотирикомпонентною афокальною системою. Для обох афокальних систем наведені формули розрахунку дальності, які дозволяють враховувати зсув переднього фокусу при зміні кутового збільшення афокальної системи.
Identificazione di diagnosi infermieristiche NANDA-I e ICNP specifiche per la terapia intensiva: una scoping review
Authors: Masciullo Mirko , Pucci Antonello , Marti Flavio , Latina Roberto , Torretta Claudia , Mitello Lucia , Marucci Anna Rita 
Published: July 2023

Introduzione: Negli ultimi anni, è emersa la necessità di utilizzare terminologie standardizzate per descrivere il processo di nursing e l’attività infermieristica. I linguaggi sono basati su evidenze scientifiche, garantendo continuità assistenziale al paziente e maggiore visibilità della professione. In questo studio vengono identificate le diagnosi infermieristiche, secondo tassonomia NANDA-I (North American Nursing Diagnosis Association International) e ICNP (Classificazione Internazionale per la Pratica Infermieristica), più utilizzate nel contesto specifico della terapia intensiva per adulti.
Materiali e Metodi: è stata effettuata una revisione della letteratura scientifica di tipo Scoping Review tra marzo e novembre 2022. Sono stati inclusi gli studi primari pubblicati tra il 2012 e il 2022, provenienti da tre differenti banche dati, escludendo campioni di pazienti affetti da COVID-19 o con dati aggregati di diversi contesti assistenziali.
Risultati: sono stati selezionati 9 articoli che rispondevano al quesito riguardo alla tassonomia NANDA-I, mentre nessun articolo è stato incluso per il linguaggio ICNP. Nei 9 articoli veniva analizzato un campione totale di 817 pazienti provenienti da Brasile, Italia e Turchia. In questo studio le diagnosi NANDA-I incluse sono state 44, tra cui le più utilizzate: “(00004) Rischio di infezione”, “(00047) Rischio di integrità cutanea compromessa”, “(00030) Scambi gassosi compromessi”. Sono riassunti nell’articolo i dati di frequenza delle diagnosi risultate più comuni nel contesto assistenziale analizzato.
Discussione: gli infermieri pongono grande attenzione alla prevenzione, formulando spesso diagnosi di rischio in aggiunta a quelle reali. Tuttavia, si è evidenziata una tendenza a considerare maggiormente i bisogni fisiologici, tralasciando la sfera emozionale, spirituale e relazionale del paziente.
Conclusioni: Lo studio ha risposto al quesito di ricerca per le diagnosi NANDA-I, mentre non ha portato risultati, evidenziando un’area grigia per le diagnosi ICNP. Studi futuri saranno necessari per creare sottoinsiemi di diagnosi infermieristiche NANDA-I specifici per la terapia intensiva per adulti, al fine di ottimizzare l’uso dei linguaggi standardizzati in tale contesto assistenziale.
A mentorálás néhány folyamatjellemzője a pedagógusképzés gyakorlatában
Authors: Bíró Gyula 
Published: July 2023

A pedagógusképzés paradigmaváltás előtt áll. A pedagógusok képzése az intézmények, a fenntartók, és a pedagógusképzők együttműködésének összefüggésében vizsgálható. Jelen tanulmány a képzők szemszögéből, egy szűk keresztmetszeten keresztül mutatja be azt, hogy milyen beavatkozásokkal, milyen lehetséges változások történhetnek, akár lokális szinten alkalmazott módszertani megoldásokkal, kidolgozott eljárásokkal, akár a rendszer megújításának egészére vonatkozóan. A tanulmány rövid áttekintést nyújt a mentorálás fogalmáról, a hazai köznevelésben és felsőoktatásban használt fogalomértelmezéséről, a mentorálás típusairól, a mentorálás folyamatáról, a mentorok szakmai felkészültségéről, a mentorálási attitűdjéről. Ezen túl, bemutatásra kerülnek a mentorálással kapcsolatos vélemények és tapasztalatok vizsgálatai eredményeinken keresztül. A tanulmány lehetséges fejlesztési irányokat fogalmaz meg a hazai mentorálás gyakorlatában, a pedagógusképzés modernizációját fókuszba helyezve.
Formulation and Evaluation of Buccoadhesive Tablet of Verapamil Hydrochloride for the Treatment of Hypertension
Authors: Thipe Sohan Sukaldas , Sawale Amol V , Muneshwar Shraddha Dilip , Gulhane Shiwani A , Gahukar Sakshi S 
Published: July 2023

The creation and assessment of buccoadhesive tablets of verapamil hydrochloride were the study's primary goals. Blood pushing excessively hard against the arterial wall is referred to as hypertension. Typically, hypertension is characterized by blood pressure readings over 140/90; readings over 180/120 are regarded as severe hypertension. Verapamil is used to manage angina (chest pain) and treat excessive blood pressure. Verapamil belongs to the category of drugs known as calcium channel blockers. In order to save the heart from having to pump as hard, it relaxes the blood artery. Additionally, it enhances the heart's blood and oxygen flow while decreasing electrical activity to regulate heart rate. Five formulations that demonstrated satisfactory physicochemical characteristics and drug release were chosen for the investigation. Physical examination, weight fluctuation, uniformity of content, thickness, friability, hardness, and in vitro drug release were used to characterize the formulation. In terms of physical examination, weight variation, uniformity of content, thickness, friability, hardness, and in vitro drug release, all formulations produce satisfactory results. The buccoadhesive tablet formulation (F2 Batch) had the best in vitro drug release of 87% in 8 hours. Verapamil hydrochloride's UV spectrum was examined, and it was discovered that the drug's highest absorbance occurs at 227nm, increasing its bioavailability.
Keywords: Verapamil Hydrochloride, Hypertension, Bioavailability, Buccoadhesive Tablet, Calcium channel blocker.
The human right to travel and movement in public international law
Authors: عبدالله الصواف عبدالله ذنون 
Published: July 2023

Human is by nature a moving being who must move from one place to another as he wishes and at any time and by the means he wants, including to protect his physical and psychological health together, thus preparing the freedom of travel and movement from personal freedoms crisis to the human being and personal freedoms that are considered fundamental freedoms at the forefront of freedoms as a condition for the possibility of enjoying other rights and public freedoms, but it is the pillar on which all other freedoms recant, what is the value of man If he is not determined by the freedom to travel to and from the borders of the country in which he resides permanently, or to travel to and from other countries in accordance with the provisions of the law. If freedom of travel and movement is one of the fundamental freedoms of the human being, that freedom is not absolute
in positive legislation, but is regulated to allow individuals wishing to enjoy it without violating it or wasting it in order to preserve its interests and the interests of society.
The effect of Market Orientation on Export Performance: The Mediating role of New Product Development capability
Authors: Wakjira Gada Gizachew 
Published: July 2023

The aim of this study that titled the descriptive statistics of Market Orientation practice on Export Performance the Mediating role of new product development practice with Positive effect of export performance provides firms with opportunity to grow, and enhance the dynamism in the new product development. In this study, two main strategies that are refer to Market Orientation and new product development is investigated and determines the Export Performance. This study focused in Coffee trading and Factory PLC Ethiopia. The findings showed that the Descriptive effect of Market Orientation on Export Performance the Mediating role of New Product Development Capability. However, the market orientation is much stronger in influence the export performance that affect Market orientation through new product development on Export performance, it designed with Descriptive Statistics to distribute for 384 respondents, and the questionnaires to be distributed from Primary and Secondary Cooperative Union, Coffee supplier, Coffee Collector, Employee of PLC. Hence, this study basically increased the knowledge regarding of the factors that affect the Export Performance, especially in Oromia Regional state West Guji zone Coffee trading and Factory PLC, Ethiopia.
2D Mathematical Model of Damping in Cellular Materials
Authors: Kovalev Alexander , Filippov Alexander E. , Gorb Stanislav N. 
Published: July 2023

AbstractMany biological materials may be considered as cellular materials, for example, soft tissues, but also bones, wood, or foam‐like medulla in a bird feather. The cells may be filled with a fluid or just with air, have different size, shape, and wall thickness. Less is known about how the mechanical and morphological parameters of the cellular materials influence their biologically relevant functions. A simple descriptive 2D numerical model of a cellular material based on Voronoi diagrams is presented here which aims prompt investigation how structural parameters influence its physical properties. The preliminary numerical simulations demonstrate that with an increasing wall thickness the energy dissipation increases and with an increasing cell density also an average stress increases. Other interesting results are that an increased dissipation constant of cellular material reduces the stress, and that in hierarchical foams the dissipation takes place mostly in the thick walls. The presented approach allows screening the influence of further material features and structural parameters, such as for example, different kinds of gradients or different properties of biological or biologically inspired cellular materials at different loading conditions. Direct comparison of different real biological structures could be also performed, especially when real experimental measurements are impossible.
Maternal occupational exposure to selected organic and chlorinated solvents and delivery of small‐for‐gestational age or preterm infants
Authors: Van Buren Kristen W. , Rocheleau Carissa M. , Chen I‐Chen , Desrosiers Tania A. , Sanderson Wayne T. , Politis Maria D. , Ailes Elizabeth C. ,   The National Birth Defects Prevention Study
Published: July 2023

AbstractBackgroundPotential reproductive effects of organic solvent exposure during pregnancy remain unclear. We investigated the association between maternal occupational exposure during pregnancy to six chlorinated solvents, three aromatic solvents, and Stoddard solvent, and delivery of preterm infants or those born small‐for‐gestational age (SGA).MethodsIn this case–control study of SGA and preterm birth (PTB) nested within the National Birth Defects Prevention Study (NBDPS) from 1997 to 2011, we analyzed data from 7504 singleton live births without major birth defects and their mothers. Self‐reported information on jobs held in the periconceptional period was assessed for solvent exposure. Unconditional logistic regression was used to estimate the association between maternal occupational exposure (any, none) during early pregnancy to organic solvents and PTB and SGA. Linear regression was used to examine changes in mean birthweight potentially associated with maternal occupational solvent exposure.ResultsMaternal occupational exposure to any organic solvents overall was not associated with an increased odds of PTB (adjusted odds ratio [aOR] = 0.94; 95% confidence interval [CI] 0.67–1.33) or SGA (aOR = 0.93; 95% CI 0.65–1.34). Point estimates increased modestly for higher estimated exposure versus lower, but confidence intervals were wide and not statistically significant. Maternal exposure to solvents was not associated with a statistically significant change in term birthweight among infants.ConclusionsOccupational exposure to organic solvents at the frequency and intensity levels found in a population‐based sample of pregnant workers was not associated with PTB or SGA; however, we cannot rule out any effects among pregnant workers with uncommonly high exposure to organic solvents.
Macrophage and monocyte subsets in response to ischemic stroke
Authors: Blank‐Stein Nelli , Mass Elvira 
Published: July 2023

AbstractIschemic stroke is a leading cause of disability and mortality. Despite extensive efforts in stroke research, the only pharmacological treatment currently available is arterial recanalization, which has limited efficacy only in the acute phase of stroke. The neuroinflammatory response to stroke is believed to provide a wider time window than recanalization and has therefore been proposed as an attractive therapeutic target. In this review, we provide an overview of recent advances in the understanding of cellular and molecular responses of distinct macrophage populations following stroke, which may offer potential targets for therapeutic interventions. Specifically, we discuss the role of local responders in neuroinflammation, including the well‐studied microglia as well as the emerging players, border‐associated macrophages, and macrophages originating from the skull bone marrow. Additionally, we focus on the behavior of monocytes stemming from distant tissues such as the bone marrow and spleen. Finally, we highlight aging as a crucial factor modulating the immune response, which is often neglected in animal studies.
Short‐term exposure to ambient air pollution and COVID‐19 severity during SARS‐CoV‐2 Delta and Omicron waves: A multicenter study
Authors: Poniedziałek Barbara , Rzymski Piotr , Zarębska‐Michaluk Dorota , Rogalska Magdalena , Rorat Marta , Czupryna Piotr , Kozielewicz Dorota , Hawro Marcin , Kowalska Justyna , Jaroszewicz Jerzy , Sikorska Katarzyna , Flisiak Robert 
Published: July 2023

AbstractAir pollution may affect the clinical course of respiratory diseases, including COVID‐19. This study aimed to evaluate the relationship between exposure of adult patients to mean 24 h levels of particulate matter sized <10 μm (PM10) and <2.5 μm (PM2.5) and benzo(a)pyrene (B(a)P) during a week before their hospitalization due to SARS‐CoV‐2 infection and symptomatology, hyperinflammation, coagulopathy, the clinical course of disease, and outcome. The analyses were conducted during two pandemic waves: (i) dominated by highly pathogenic Delta variant (n = 1440) and (ii) clinically less‐severe Omicron (n = 785), while the analyzed associations were adjusted for patient's age, BMI, gender, and comorbidities. The exposure to mean 24 h B(a)P exceeding the limits was associated with increased odds of fever and fatigue as early COVID‐19 symptoms, hyperinflammation due to serum C‐reactive protein >200 mg/L and interleukin‐6 >100 pg/mL, coagulopathy due to
d‐dimer >2 mg/L and fatal outcome. Elevated PM10 and PM2.5 levels were associated with higher odds of respiratory symptoms, procalcitonin >0.25 ng/mL and interleukin >100 pg/mL, lower oxygen saturation, need for oxygen support, and death. The significant relationships between exposure to air pollutants and the course and outcomes of COVID‐19 were observed during both pandemic waves. Short‐term exposure to elevated PM and B(a)P levels can be associated with a worse clinical course of COVID‐19 in patients requiring hospitalization and, ultimately, contribute to the health burden caused by SARS‐CoV‐2 variants of higher and lower clinical significance.
Genotypic analysis of a large cohort of patients with suspected atypical hemolytic uremic syndrome
Authors: Connaughton Dervla M. , Bhai Pratibha , Isenring Paul , Mahdi Mohammed , Sadikovic Bekim , Schenkel Laila C. 
Published: July 2023

Abstract
Atypical hemolytic uremic syndrome (aHUS) is characterized by microangiopathic hemolytic anemia, thrombocytopenia, and renal impairment. Complement and coagulation gene variants have been associated with aHUS susceptibility. We assessed the diagnostic yield of a next-generation sequencing (NGS) panel in a large cohort of Canadian patients with suspected aHUS. Molecular testing was performed on peripheral blood DNA samples from 167 patients, collected between May 2019 and December 2021, using a clinically validated NGS pipeline. Coding exons with 20 base pairs of flanking intronic regions for 21 aHUS-associated or candidate genes were enriched using a custom hybridization protocol. All sequence and copy number variants were assessed and classified following American College of Medical Genetics guidelines. Molecular diagnostic results were reported for four variants in three individuals (1.8%). Twenty-seven variants of unknown significance were identified in 25 (15%) patients, and 34 unique variants in candidate genes were identified in 28 individuals. An illustrative patient case describing two genetic alterations in complement genes is presented, highlighting that variable expressivity and incomplete penetrance must be considered when interpreting genetic data in patients with complement-mediated disease, alongside the potential additive effects of genetic variants on aHUS pathophysiology. In this cohort of patients with suspected aHUS, using clinical pipelines for genetic testing and variant classification, pathogenic/likely pathogenic variants occurred in a very small percentage of patients. Our results highlight the ongoing challenges in variant classification following NGS panel testing in patients with suspected aHUS, alongside the need for clear testing guidance in the clinical setting.

Key messages
• Clinical molecular testing for disease associated genes in aHUS is challenging.
• Challenges include patient selection criteria, test validation, and interpretation.
• Most variants were of uncertain significance (31.7% of patients; VUS + candidates).
• Their clinical significance may be elucidated as more evidence becomes available.
• Low molecular diagnostic rate (1.8%), perhaps due to strict classification criteria.
• Case study identified two likely pathogenic variants; one each in MCP/CD46 and CFI.
Development of an in chemico high-throughput screening method for the identification of skin sensitization potential
Authors: Ferreira Isabel , Brites Gonçalo , Silva Ana , Caramelo Francisco , Oliveiros Bárbara , Neves Bruno Miguel , Cruz Maria Teresa 
Published: July 2023

AbstractIt is well established that chemical-peptide conjugation represents the molecular initiating event (MIE) in skin sensitization. This MIE has been successfully exploited in the development of in chemico peptide reactivity assays, with the Direct Peptide Reactivity Assay (DPRA) being validated as a screening tool for skin sensitization hazard as well as an OECD test guideline. This test relies on the use of a high-performance liquid chromatography/ultraviolet detection method to quantify chemical-peptide conjugation through measurement of the depletion of two synthetic peptides containing lysine or cysteine residues, which is labor-intensive and time-consuming. To improve assay throughput, sensitivity, and accuracy, we have developed a spectrophotometric assay for skin sensitization potential based on MIE measurement—the ProtReact assay. ProtReact is also a cheaper, faster, simpler, and more accessible alternative for the DPRA, giving comparable results. A set of 106 chemicals was tested with ProtReact and the peptide depletion values compared with those reported for the DPRA. The predictive capacity of both assays was evaluated with human reference data. ProtReact and DPRA assays show similar predictive capacities for hazard identification (75% and 74%, respectively), although ProtReact showed a higher specificity (86% versus 74%, respectively) and lower sensitivity (69% versus 73%). Overall, the results show that ProtReact assay described here represents an efficient, economic, and accurate assay for the prediction of skin sensitization potential of chemical haptens.