bluuebunny/crossref_metadata_2025_split huggingface dataset:
Kompetensi Teknis Peternak Sapi Potong di Kabupaten Timor Tengah Utara dan Kabupaten Belu
Authors: Simamora Ture , Fatchiya Anna , Sadono Dwi , Asngari Pang Suparman 
Published: May 2023

ABSTRACT. Pembangunan peternakan yang bertujuan meningkatkan produktivitas sapi potong belum menunjukkan hasil nyata di Provinsi Nusa Tenggara Timur. Hal ini disebabkan oleh peternakan rakyat masih bersifat tradisional dalam mengelola usaha sapi potong. Dengan demikian kompetensi menjadi aspek yang harus dimiliki peternak agar bisa mengelola usaha ternak secara benar dan menghasilkan produktivitas yang tinggi. Penelitian ini bertujuan untuk menganalisis tingkat kompetensi teknis peternak sapi potong di Kabupaten Timor Tengah Utara dan Kabupaten Belu. Penelitian menggunakan penelitian kuantitatif dengan rancangan penelitian survei yang bersifat menerangkan (explanatory research). Metode yang digunakan dalam penelitian ini adalah metode survei. Penelitian dilakukan di Kabupaten Timur Tengah Utara dan Kabupaten Belu. Jumlah sampel yang diambil di wilayah penelitian sebanyak 462 orang. Hasil penelitian menunjukkan Tingkat kompetensi teknis peternak berbeda nyata antara Kabupaten Timor Tengah Utara dan Kabupaten Belu. Secara umum kompetensi teknis peternak kategori tinggi (rerata = 55,32) di kedua kabupaten tersebut. Kompetensi peternak perlu ditingkatkan dengan meningkatkan kualitas layanan penyuluhan yang sesuai kebutuhan peternak serta melakukan pelatihan teknis usaha sapi potong. (Technical competence of beef cattle breeders in Timor Tengah Utara and Belu regencies) ABSTRAK. The development that aims to increase cattle productivity has not shown tangible results in the province of East Nusa Tenggara. This is because people's farms are still traditional in managing beef cattle business. Thus, competence is an aspect that must be owned by breeders in order to properly manage livestock business and produce high productivity. This study aims to analyze the level of technical competence of beef cattle breeders in North Central Timor Regency and Belu Regency. This research uses quantitative research with a descriptive research design (explanatory research). The method used in this research is a survey method. The research was conducted in North Middle East and Belu Districts. The number of samples taken in the research area was 462 people. The results showed that the level of technical competence of farmers was significantly different between North Central Timor Regency and Belu Regency. Competence needs to be improved by improving the quality of extension services according to the needs of breeders and conducting beef cattle business technicalities.
Devenir des jeunes ruminants laitiers : comment concilier élevage et attentes sociétales
Authors: POMIÈS Dominique , CONSTANCIS Caroline , JURQUET Julien , VEISSIER Isabelle , CAILLAT Hugues , LAGRIFFOUL Gilles , DROUET Marie , FOSSAERT Clément , LE COZLER Yannick 
Published: May 2023

Dans les conditions naturelles, les jeunes ruminants développent un lien privilégié avec leur mère dans les heures qui suivent la naissance, lien qui perdure bien au-delà de l’allaitement. Or, sur les 5,5 millions de jeunes ruminants (veaux, chevreaux et agneaux) qui naissent chaque année en France dans des élevages laitiers, la grande majorité sont séparés de leur mère à la naissance et allaités « artificiellement » au seau. La séparation mère-jeune précoce interpelle les citoyens et certains éleveurs quant au respect du bien-être de l’animal. L’allaitement artificiel des femelles de renouvellement jusqu’au sevrage permet d’assurer, à un coût maîtrisé, un développement mammaire optimal et un bon potentiel laitier. Cependant, l’allaitement par les mères ou par des nourrices se développe, principalement en élevage bovin. Ce type d’allaitement entraîne généralement des quantités de lait commercialisables moindres, mais la croissance, la santé et le bien-être des veaux sont améliorés. Des questions se posent aussi sur le devenir des jeunes, mâles pour l’essentiel, non conservés pour le renouvellement du troupeau. Ceux-ci quittent généralement l’élevage quelques semaines après la naissance pour être engraissés dans des ateliers spécialisés, voire exportés. Là aussi, afin de répondre aux nouvelles attentes des consommateurs et pallier le faible intérêt économique de ces débouchés, éleveurs et filières recherchent des solutions alternatives telles que l’engraissement à la ferme, de nouveaux modes d’élevage ou de nouveaux débouchés. Ces pratiques alternatives – allaitement naturel ou engraissement sur place des jeunes mâles – pourraient se développer grâce à une identification de leurs produits (lait, viande) et au consentement du consommateur à les payer plus cher que des produits standards.
Overview Analysis of Recent Developments on Self-Driving Electric Vehicles
Authors: Ajao Qasim 
Published: May 2023

This paper provides a comprehensive overview of recent advancements in autonomous electric vehicle (AEV) within the specified region. It elaborates on the progress and comparative analysis of diverse subsystems, including energy storage, cell balancing for battery systems, vehicle charger layouts, electric
vehicle motor mechanisms, and braking systems. Furthermore, this paper showcases several prototype autonomous electric vehicles as conclusive study findings.
Systematic human learning by literature and data mining for feature selection in machine learning
Authors: Sufriyana Herdiantri , Wu Yu Wei , Su Emily Chia-Yu 
Published: May 2023

Abstract
We proposed a learning algorithm for human to conduct literature and data mining for causal factor discovery. The applicability is to select features for a machine learning prediction model, including but not limited to that using real-world, time-varying data from electronic health records. This protocol is relatively quick to find potentially actionable predictors for a clinical prediction while dealing with high dimensionality in big data. However, this protocol might not find a potentially novel cause, since this only exhaustively examines the existing evidences in a single study. The key stages consisted of systematic human learning, causal diagram construction, data preprocessing, causal inference modeling, and development and validation of a prediction model to describe the explainability.
Fire frequency effects on plant community characteristics in the Great Basin and Mojave Deserts of North America
Authors: Stanton Rebekah L. , Nusink Baylie C. , Cass Kristina L. , Bishop Tara B.B. , Woodbury Brianna , Armond David , Clair Sam St. 
Published: May 2023

Abstract
Background:
Wildfire regimes are changing dramatically across North American deserts with the spread of invasive grasses that perpetuate invasive grass fire cycles, resulting in larger and more frequent fires. This study experimentally compared how single and repeat fires, a characteristic of invasive grass fire cycles, influence plant fuels dominated by invasive grasses, in the Great Basin and Mojave Deserts. Both study sites had an identical study design. In the summer of 2011, we experimentally burned half of each experimental block the other half remaining as an unburned control. Half of the burned plots were reburned five years later to simulate a repeat burn characteristic of increasing burn frequency. We estimated non-woody plant biomass, cover and density in plots from 2017-2020.
Results:
Biomass did not vary between sites, but there was higher plant cover but lower plant density at the Mojave site than the Great Basin site. Plant biomass, density and cover varied significantly across years, with stronger annual fluctuations in the Great Basin. At both desert sites, fire increased plant density and biomass compared to unburned plots but had no effect on biomass. The effect of fire on plant cover varied significantly between years for both deserts but was greater in the Great Basin than the Mojave site. Repeat fires did not amplify the initial fire effects.
Conclusions:
The results suggest that annual fluctuations in fine fuel production generally, and in response to fire was more responsive at the Great Basin site than the Mojave site, with no compounding effect of repeat fires.
Assessing Public Health Preparedness and Response in the European Union. A Review of Eu-Level Simulation Exercises and After Action Reviews
Authors: Utheim Mari Nythun , Gawad Mohammed , Nygård Karin , Macdonald Emily , Falk Monica 
Published: May 2023

Abstract
Background: In order to improve preparedness and response capacities in the European Union, a good overview of capacities at both country and union level is needed. The International Health Regulations (2005) Monitoring and Evaluation framework aims to assess capacities in countries. It includes semi-quantitative tools such as the State Parties Annual Report (SPAR) and the Joint External Evaluation (JEE). After Action Reviews (AAR) and Simulation Exercises (SimEx) were included to identify weaknesses in the functionality of capacities which are not addressed by SPAR and JEE. This study presents an analysis of the use of these tools on a regional level, in Europe. It aims to identify their added value by comparing them to standardised monitoring tools and lessons learned from COVID-19, and considers ways to improve their use in assessing capacities in the EU.Methods: We included 17 SimEx and 2 AAR organized by the European Commission between 2005 and 2018. We categorized a total of 357 recommendations according to the IHR (2005) core capacities they addressed and their target audience. We analysed data using language analysis software. Recommendations to countries were compared to SPAR and JEE indicators. Recommendations to EU agencies were compared to the current mandates of the EU agencies, and to lessons learnt during COVID-19.Results: Of all the extracted recommendations, 59% targeted EU agencies, 18% targeted countries, and 16% targeted both. Recommendations mainly addressed areas of IHR coordination (C2), heath emergency management (C7) and risk communication (C10), and not low scoring areas. Recommendations complement SPAR indicators by identifying gaps in functionality. Eight out of ten early lessons learnt during the Covid-19 pandemic had been raised earlier as recommendations from exercises. Exercise reports assessed did not include or result in action plans for implementation, but COVID-19 has accelerated implementation of some recommendations.Conclusion: SimEx/AAR provide valuable insight into public health preparedness at EU level, as they assess functionality of response mechanisms, point out gaps, and provide training and awareness for participants, who often have key roles in public health emergencies. Better follow-up and implementation of recommendations can improve the regional preparedness for international public health incidents.
Bivalent and Monovalent SARS-CoV-2 Variant Vaccine Boosters Improve coverage of the known Antigenic Landscape: Results of the COVID-19 Variant Immunologic Landscape (COVAIL) Trial
Authors: Branche Angela , Rouphael Nadine , Diemert David , Falsey Ann , Losada Cecilia , Baden Lindsey (R) , Frey Sharon , Whitaker Jennifer , Little Susan , Anderson Evan , Walter Emmanuel , Novak Richard , Rupp Richard , Jackson Lisa , Babu Tara , Kottkamp Angelica , Luetkemeyer Annie , Immergluck Lilly , Presti Rachel , Backer Martin , Winokur Patricia , Mahgoub Siham , Goepfert Paul , Fusco Dahlene , Malkin Elissa , Bethony Jeff , Walsh Edward , Graciaa Daniel , Samaha Hady , Sherman Amy , Walsh Stephen , Abate Getahun , Oikonomopoulou Zacharoula , Sahly Hana El , Martin Thomas , Kamidani Satoshi , Smith Michael , Ladner Benjamin , Porterfield Laura , Dunstan Maya , Wald Anna , Davis Tamia , Atmar Robert , Mulligan Mark , Lyke Kirsten , Posavad Christine , Meagher Megan , Stephens David , Neuzil Kathleen , Abebe Kuleni , Hill Heather , Albert Jim , Telu Kalyani , Mu Jinjian , Lewis Teri , Giebeig Lisa , Eaton Amanda , Netzl Antonia , Wilks Sam , Tureli Sina , Makhene Mamodikoe , Crandon Sonja , Montefiori David , Makowski Mat , Smith Derek , Nayak Seema , Roberts Paul , Beigel John 
Published: May 2023

Abstract
Vaccine protection against COVID-19 wanes over time and has been impacted by the emergence of new variants with increasing escape of neutralization. The COVID-19 Variant Immunologic Landscape (COVAIL) randomized clinical trial (clinicaltrials.gov NCT 05289037) compares the breadth, magnitude and durability of antibody responses induced by a second COVID-19 vaccine boost with mRNA (Moderna mRNA-1273 and Pfizer-BioNTech BNT162b2), or adjuvanted recombinant protein (Sanofi CoV2 preS DTM-AS03) monovalent or bivalent vaccine candidates targeting ancestral and variant SARS-CoV-2 spike antigens (Beta, Delta and Omicron BA.1). We found that boosting with a variant strain is not associated with loss in neutralization against the ancestral strain. However, while variant vaccines compared to the prototype/wildtype vaccines demonstrated higher neutralizing activity against Omicron BA.1 and BA.4/5 subvariants for up to 3 months after vaccination, neutralizing activity was lower for more recent Omicron subvariants. Our study, incorporating both antigenic distances and serologic landscapes, can provide a framework for objectively guiding decisions for future vaccine updates.
Using the Kidney Failure Risk Equation to predict end-stage kidney disease in CKD patients of South Asian ethnicity: an external validation study
Authors: Maher Francesca , Teece Lucy , Major Rupert W , Bradbury Naomi , Medcalf James F , Brunskill Nigel J , Booth Sarah , Gray Laura J 
Published: May 2023

Abstract
Background:
The Kidney Failure Risk Equation (KFRE) predicts the 2- and 5-year risk of needing kidney replacement therapy (KRT) using four risk factors – age, sex, urine albumin-to-creatinine ratio (ACR), and creatinine-based estimated glomerular filtration rate (eGFR). Although the KFRE has been recalibrated in a UK cohort, this did not consider minority ethnic groups. Further validation of the KFRE in different ethnicities is a research priority. The KFRE also does not consider the competing risk of death, which may lead to overestimation of KRT risk. This study externally validates the KFRE for patients of South Asian ethnicity and compares methods for accounting for ethnicity and the competing event of death.
Methods:
Data were gathered from an established UK cohort containing 35,539 individuals diagnosed with chronic kidney disease. The KFRE was externally validated and updated in several ways taking into account ethnicity, using recognised methods for time-to-event data, including the competing risk of death. A clinical impact assessment compared the updated models through consideration of referrals made to secondary care.
Results:
The external validation showed the risk of KRT differed by ethnicity. Model validation performance improved when incorporating ethnicity and its interactions with ACR and eGFR as additional risk factors. Further, accounting for the competing risk of death improved prediction. Using a criteria of 5 year ≥5% predicted KRT risk, the competing risks model resulted in an extra 3 unnecessary referrals (0.59% increase) but identified an extra 1 KRT case (1.92% decrease) compared to the previous best model. A hybrid criteria of predicted risk using the competing risks model and ACR ≥70mg/mmol should be used in referrals to secondary care.
Conclusions:
The accuracy of KFRE prediction improves when updated to consider South Asian ethnicity and to account for the competing risk of death. This may reduce unnecessary referrals whilst identifying risks of KRT and could further individualise the KFRE and improve its clinical utility. Further research should consider other ethnicities.
Development, Feasibility, and Acceptability of SPoRT: a Dating Violence and Sexual Risk Prevention Intervention for College Student-Athletes
Authors: Jaffe Nicole , Jones Meredith C. , Angelone DJ 
Published: May 2023

Abstract
Background. Student-athletes are one subgroup of college students in the United States at risk for dating violence and sexual risk behaviors. Despite this, research on student-athletes’ dating behaviors is limited; existing research pertains primarily to NCAA Division I athletes, and focuses on male student-athletes as perpetrators of dating and sexual violence. While some existing programs aim to reduce dating violence and promote healthy relationships, these programs are education-based, and not tailored to the specific strengths and challenges of student-athletes. We therefore designed Supporting Prevention in Relationships for Teams (SPoRT), a novel, four-session prevention intervention for Division III student-athletes of all genders to reduce dating violence and sexual risk behavior by targeting knowledge and skills identified in pilot research, incorporating psychoeducation with techniques from cognitive-behavioral therapy, mindfulness, bystander intervention, and normative feedback.
Methods. This study represents stage 1 of the NIH Stage Model for Behavioral Intervention Development, evaluating the feasibility and acceptability of SPoRT. We describe the development, content, and proposed delivery methods for SPoRT, and evaluated the feasibility and acceptability of the program using a mixed-methods approach. Thirty college student-athletes (12 men, 18 women) completed questionnaires and participated in focus groups to provide feedback on the program’s length, timing, group size and dynamics, content, and suggestions for making the SPoRT prevention intervention more feasible and acceptable.
Results. Our recruitment procedures were successful, and participants rated the program as feasible in terms of delivery methods and logistics. Participants liked that SPoRT was developed based on pilot data collected from student-athletes, brief, skills-based, and tailored to athletic team needs. SPoRT was perceived as appropriate and relevant to student-athlete needs in terms of dating violence and sexual risk prevention knowledge and skills. Most participants (63%) rated the program as “excellent” and said they would recommend it to others.
Conclusions. We found SPoRT to be both feasible and acceptable in terms of content and delivery. Suggested modifications will be incorporated into the SPoRT healthy relationships prevention intervention to be tested in an NIH Stage I efficacy trial.
Trial Registration: Not applicable.
Tremor clustering reveals precursors and evolution of the 2021 Geldingadalir eruption
Authors: Zali Zahra , mousavi s.mostafa , Ohrnberger Matthias , Eibl Eva , cotton fabrice 
Published: May 2023

Abstract
Timely manner seismic data processing and analyses are essential for potential eruption prediction and early warning in volcanology. However, the complexity of eruption processes and precursory activities makes the analysis challenging. Here, we show that advanced machine learning techniques can provide an effective and efficient tool for extracting overlooked information from continuous seismic signal recorded during the 2021 Geldingadalir eruption in Iceland and reveal the temporal evolution of the eruptive activity. We identify the major phases of the eruption based on observed seismic signals throughout the eruptive activity. We distinguish unrest activities, continuous lava extrusion, and different levels of lava fountaining. We discover a precursory volcanic tremor sequence starting three days prior to the eruption, which could be used as an indicator of imminent eruptive activity. Based on the extracted patterns of seismicity and their temporal variations we provide an explanation for the transition mechanism from vigorous outflow to lava fountaining. Our observation suggests that the transition to episodic tremors in the seismic signal in early May, could be a result of an increase in the discharge rate in late April.
Spatial and Single-Cell Analyses Reveal Correlation between Histone H2A Dioxygenase Gene Expression and Tumor-Associated Macrophages in Gastric Cancer
Authors: Chang Renin , Tsui Kuan-Hao , Tzeng Yen-Dun Tony , Hsiao Jui-Hu , Tsang Yi-Ling , Kuo Chen-Hsin , Li Chia-Jung 
Published: May 2023

Abstract

BackgroundALKBH1 is an important enzyme involved in various cellular processes that regulates RNA demethylation in humans. While its contribution to tumor progression is known, its role in gastric cancer remains unclear. Further research is needed to explore the potential of ALKBH1 in clinicopathology, tumor immune microenvironment, and precision oncology for STAD.MethodsThis study used a multi-omics approach to identify ALKBH1 as an independent diagnostic biomarker for STAD with a correlation to advanced clinical status and poor overall survival rate. We analyzed publicly available datasets from GEO and TCGA, identifying differentially expressed genes in STAD and examined their relationship with immune gene expression, overall survival, tumor stage, gene mutation status, and infiltrating immune cells. We also explored ALKBH1 gene expression in different regions of the STAD using spatial transcriptomics. In addition, we utilized spatial transcriptomic and single-cell RNA-sequencing methods to investigate the correlation between PGAM1 and immune cells. We further confirmed our results by analyzing 60 STAD patient samples and examining the relationship between ALKBH1 expression, clinicopathological features, and prognosis using immunohistochemistry and bioinformatics.ResultsOur study revealed the expression of key gene regulators in gastric cancer that were associated with genetic variations, deletions, and the tumor microenvironment. Mutations in these regulators were positively linked to distinct immune cells in six immune datasets and played a vital role in immune cell infiltration in STAD. We found that high ALKBH1 expression was associated with macrophage infiltration in STAD. Moreover, pharmacogenomic analysis of renal cancer cell lines indicated that ALKBH1 inactivation was correlated with increased sensitivity to specific small-molecule drugs.ConclusionTo sum up, the study indicates that alterations in ALKBH1 may play a role in STAD advancement and reveal new diagnostic and prognostic implications of ALKBH1 in STAD. It emphasizes the importance of ALKBH1 in the tumor immune microenvironment, implying its potential utility as a precision medicine tool and for drug screening in STAD.
Integrated single-cell and bulk RNA sequencing analysis identifies the predictive signature for prognosis and neoadjuvant chemotherapy responses in breast cancer
Authors: Feng Ran , Guo Junbin , Pan Lihui , Yao Yarong , Gao Jinnan , Zhang Xiaojuyn 
Published: May 2023

Abstract
Neoadjuvant chemotherapy (NAC) is a well-established treatment modality for locally advanced breast cancer (BC). However, it can also result in severe toxicities while controlling tumors. Therefore, reliable predictive biomarkers are urgently needed to objectively and accurately predict NAC response. This study aims to integrate single-cell and bulk RNA-seq data to identify key regulatory factors that contribute to NAC response in BC patients. In specific, we construct an NAC prognostic risk model based on the nine identified prognostic NAC response-related genes and demonstrate its clinical independence and generalizability. Additionally, we explore the underlying cancer hallmarks and microenvironment features of this NAC response-related risk score, and further assess the potential impact of risk score on drug response. In summary, our study involved the development of prognostic biomarkers for NAC in BC, which was accomplished through the integration of single-cell and bulk RNA data. The results of our study are of crucial significance in the prediction of the efficacy of NAC in BC, and may have implications for the clinical management of this disease.