bluuebunny/crossref_metadata_2025_split huggingface dataset:
Biogenic synthesis of titanium nanoparticles by Streptomyces rubrolavendulae for sustainable management of Icerya aegyptiaca (Douglas)
Authors: Elqady Enayat M. , El-said Eman , Tharwat Asmaa A. , El-Khashab Lina A. Abou , Mostafa Inas M. Y. , Hamed Fatma Z. , Morsi Wesam M. , Rezk Mohamed M. , El-Enain Inas M. Abou 
Published: January 2025

AbstractBiosynthesized nanoparticles have a variety of applications, and microorganisms are considered one of the most ideal sources for the synthesis of green nanoparticles. Icerya aegyptiaca (Douglas) is a pest that has many generations per year and can affect 123 plant species from 49 families by absorbing sap from bark, forming honeydew, causing sooty mold, and attracting invasive ant species, leading to significant agricultural losses. The purpose of this work was to synthesize titanium dioxide nanoparticles (TiO2-NPs) from marine actinobacteria and evaluate their insecticidal effects on Icerya aegyptiaca (Hemiptera: Monophlebidae), in addition to explaining their effects on protein electrophoresis analysis of SDS‒PAGE proteins from control and treated insects after 24, 72 and 120 h of exposure. In all, seven actinobacterial isolates, the most potent of which has the potential to produce titanium hydroxide-based nanoparticles (TiO2-NP2), have DNA sequences that are 99.9% like those of Streptomyces rubrolavendulae (MCN2) according to nucleotide alignment and a phylogenetic tree. The produced TiO2-NPs were verified by UV examination and characterized by FT-IR, XRD, TEM, EDX, and DLS analyses. Toxicological results revealed that TiO2-NPs have insecticidal effects and high mortality rates reaching 55, 62.5, 80 and 95% at TiO2-NPs dose 120,250,500 and 1000 ppm respectively. Compared with the control, TiO2-NP spraying caused changes in the protein pattern of I. aegyptiaca, as indicated by the disappearance of normal bands and the appearance of other bands, as well as quantitative and qualitative changes in protein content after 24, 72 and 120 h of exposure. The application of TiO2-NPs by MNC2 offers a new alternative strategy to control I. aegyptiaca and is considered a modern approach to nanotechnology.
Bayesian predictive system for assessing the damage intensity of residential masonry buildings under the impact of continuous ground deformation
Authors: Rusek Janusz , Chomacki Leszek , Słowik Leszek 
Published: January 2025

AbstractThe paper introduces a method for predicting damage intensity in masonry residential buildings situated in mining areas, focusing on the impact of large-scale continuous ground deformation. The research utilizes in situ data collected in a database, encompassing structural and material features, as well as information on maintenance quality and building durability. In addition to this information, the database collected data on the intensity of continuous deformation of the mining area at the location of the building, as well as the range and intensity of damage identified in buildings. The information included in the database was the result of many years of observations of buildings during the disclosure of impacts from mining exploitation and was based on: the results of in-situ building inventory, analysis of available building documentation and information provided by mining companies. The archived data were categorized variables labeled. The transformation of the data to a labeled value was dictated directly by the assumptions of the GOBNILP algorithm. Ultimately, a predictive model, represented by an optimal Bayesian network structure, is established. The optimisation of the network structure is achieved through the adaptation of the GOBNILP Bayesian network learning algorithm from data. This optimisation process is executed through the Gurobi Optimizer. It is worth noting that this interdisciplinary approach represents one of the first applications of such a methodology in the field of civil and environmental engineering. The results obtained can therefore be of significant value given the fact that the methodology of detecting the structure of Bayesian networks from data is still developing intensively in other scientific fields. In the course of the analyses, metric scores are examined, and various network structures are assessed based on their complexity. Great values of classification accuracies over 91% were obtained. This meticulous evaluation allows for the selection of the optimal Bayesian network that best generalises the knowledge acquired during the learning process. The paper also demonstrates the potential application of the obtained model in diagnosing damage causes and predicting future occurrences, highlighting the versatility of the proposed approach for addressing issues in the field.
Mapping mitochondrial morphology and function: COX-SBFSEM reveals patterns in mitochondrial disease
Authors: Faitg Julie , Davey Tracey , Laws Ross , Lawless Conor , Tuppen Helen , Fitton Eric , Turnbull Doug , Vincent Amy E. 
Published: January 2025

AbstractMitochondria play a crucial role in maintaining cellular health. It is interesting that the shape of mitochondria can vary depending on the type of cell, mitochondrial function, and other cellular conditions. However, there are limited studies that link functional assessment with mitochondrial morphology evaluation at high magnification, even fewer that do so in situ and none in human muscle biopsies. Therefore, we have developed a method which combines functional assessment of mitochondria through Cytochrome c Oxidase (COX) histochemistry, with a 3D electron microscopy (EM) technique, serial block-face scanning electron microscopy (SBFSEM). Here we apply COX-SBFSEM to muscle samples from patients with single, large-scale mtDNA deletions, a cause of mitochondrial disease. These deletions cause oxidative phosphorylation deficiency, which can be observed through changes in COX activity. One of the main advantages of combining 3D-EM with the COX reaction is the ability to look at how per-mitochondrion oxidative phosphorylation status is spatially distributed within muscle fibres. Here we show a robust spatial pattern in COX-positive and intermediate-fibres and that the spatial pattern is less clear in COX-deficient fibres.
Ethics: The Elixir of Publications
Authors: Singhal Manphool , Basu Suprit , Sharma Arun , Singh Paramjeet 
Published: January 2025

AbstractScientific papers are the driving force for research, information dissemination, and policymaking that directly impacts society. Thus, ethical practices are the elixir of publications. Adherence to ethical practices promotes integrity in research and publication. Transgression of ethics is thus considered a poison to science. Although there is no definition of ethics, it includes a systematic approach that not only recommends but also defends and protects concepts of the conduct of right and wrong. Therefore, ethical principles should be strictly adhered to and upheld at any cost for the progression of science. This article addresses various actions that are considered ethical misconduct and guidelines to fix them. Recommendations of various organizations related to the ethics in publications are also discussed.
Insights into Radiology Publications
Authors: Sathiadoss Paul , Bhayana Rajesh , Shaikh Zara A. , Krishna Satheesh 
Published: January 2025

AbstractThe evolution of modern medicine has been significantly driven by medical and health care research, underscoring the importance of disseminating findings to advance health care. Medical literature, encompassing various publication types such as case reports, review articles, and original research, plays a crucial role in this process by facilitating the communication and discussion of new discoveries. This review article provides a comprehensive guide to understanding and navigating radiologic publications. It examines the various types of radiologic research articles, including case reports and series, pictorial reviews, original research, systematic reviews, and meta-analyses, each of which serve distinct purposes in contributing to the field of radiology. The study adopts the “six honest men” approach—addressing why, who, what, when, where, and how—to elucidate the essential elements of successful radiology research and publication. Key topics include the motivations for publishing, the types of articles suited for different research questions, and strategic considerations for selecting appropriate journals. Additionally, the review highlights the importance of understanding publication timing, journal selection criteria, and the overall publication process, including manuscript preparation and peer review. By offering these insights, the review aims to equip early-career researchers with the knowledge and skills necessary to effectively contribute to radiology literature and advance their academic and professional careers.
Navigating Artificial Intelligence in Scientific Manuscript Writing: Tips and Traps
Authors: Kumar Ishan , Yadav Nidhi , Verma Ashish 
Published: January 2025

AbstractIt is being increasingly recognized that the strategic use of artificial intelligence (AI) can catalyze the process of manuscript writing. However, it is imperative that we recognize the hidden biases, pitfalls, and disadvantages of relying solely on AI, such as accuracy concerns and the potential erosion of nuanced human insight. With an emphasis on crafting effective prompts and inputs, this article reveals how to navigate the labyrinth of AI capabilities to create a good-quality manuscript. It also addresses the evolving guidelines from various publishers, shedding light on how to “leverage the digital genie” responsibly and ethically. We further explore how and which AI tools can be harnessed for literature reviews, executing statistical analyses, and polishing the language of the manuscript. Providing practical strategies for maximizing AI's benefits, this article underscores the indispensable value of human creativity and critical thinking, stressing that while AI can “streamline the mundane,” the author's insight remains vital for profound intellectual contributions.
Intraoperative Computed Tomography in Orthopaedic Trauma Surgery
Authors: Keil Holger , Vetter Sven Y. , Grützner Paul Alfred , Franke Jochen 
Published: January 2025

Abstract
Background When using mobile 3D C-arms, impairments in image quality occur due to artefacts caused by metal implants as well as to the limited field of view. To avoid these restrictions, special computed tomography devices were designed, in order to improve image quality and to meet requirements for intraoperative usage.
Objectives To analyse practicability and benefits of a mobile intraoperative CT device (Airo, Brainlab, Munich, Germany) on the basis of several parameters that were obtained during a 40-month period.
Materials and Methods All procedures that were performed with usage of intraoperative CT between January 2017 and April 2020 were analysed with respect to anatomical region, count of scans, duration of scans, consequences drawn from the scans and use of navigation.
Results 354 CT-scans were performed in 171 patients (mean 2.07 [1–6] scans per procedure). 47.81% of the procedures were spinal, 52.19% affected the pelvis. 83% of the procedures were navigated. In 22% of patients, improvement in implant placement or reduction was achieved; in most patients (55%), a guidewire for pedicle screws was corrected. The mean scan duration was 10.33 s (3.54–21.72).
Conclusions Use of intraoperative CT was reliable and helpful. Integration in OR standards requires more effort than mobile 3D C-arms. Image quality was outstanding for intraoperative conditions and allowed proper assessment of implant placement and reduction in all cases. Due to the high financial outlay of the system and the good image quality of 3D C-arms in the extremities, we assume that this procedure can be applied in intraoperative CT in traumatological cases in spinal and pelvic surgery in high-level trauma centres.
Importance of Hip-Spine Syndrome in Hip Arthroplasty: Influence on the Outcome and Therapeutic Consequences
Authors: Langer Severin , Stephan Maximilian , von Eisenhart-Rothe Rüdiger 
Published: January 2025

AbstractCorrect interaction between the spine, pelvis, and hip is an essential condition for successful progress after total hip replacement. Spinal pathologies, such as degeneration, fractures, and spinopelvic imbalance with and without lumbar fusions, are closely associated with an increased risk of impingement or even dislocation of the prosthesis. To significantly reduce this risk, various parameters are required to quantify the risk groups. Knowledge on the presence of stiffness of the spine (change in pelvic tilt between standing and sitting at < 10°) and sagittal spinal deformity (pelvic incidence–lumbar lordosis mismatch > 10° or 20°) is essential in identifying patients with corresponding risk. The individual risk profile can be assessed through a specific history and examination. Before total hip arthroplasty, a routine preoperative workup is recommended for high-risk patients: using information from standardised preoperative radiographs while sitting and standing (pelvis, anteroposterior view, lying and standing; spine and pelvis, lateral view, standing and sitting). Important changes can be made during the surgery. If the spine is stiff, attention should be paid to the position of the cup, with increased anteversion, sufficient offset, and larger head that is secure to dislocation – to reduce the risk of dislocation. In the case of a sagittal spinal deformity, the functional coronary pelvic level must be carefully controlled so that it is better to use double mobility cups. Digital systems, such as navigation and robotics, can optimise component positioning although, so far, there is little evidence that the complication rate decreased. Therefore, further studies are warranted.
Effects of an Integrated Geriatric-Orthopedic Co-management (InGerO) on the Treatment of Older Orthopedic Patients with Native and Periprosthetic Joint Infections
Authors: De Bueck Ulrike , Kohlhof Hendrik , Wirtz Dieter Christian , Lukas Albert 
Published: January 2025

Abstract
Purpose In view of our aging society, co-management with a geriatrician is becoming increasingly important. While such collaborations have been working successfully in trauma surgery for years, it is still unclear whether they are also helpful for non-trauma patients in orthopedics. The aim of this study was to investigate the effect of such a cooperation in orthopedic non-trauma patients with native and periprosthetic joint infections on the basis of five key areas.
Methods A retrospective observational study as a before and after comparison was used to compare routine data from patients with and without orthogeriatric co-management after nontraumatic surgery. Eligible patients for the study were 70 years and older, had a diagnosis of hip, knee, or shoulder infection, and had been hospitalized for at least 14 days. Co-management consisted of close follow-up by a geriatrician, Comprehensive Geriatric Assessment, and “complex early geriatric rehabilitation”. The comparison group received therapy as usual, without a geriatrician and without “complex early geriatric rehabilitation”. Special attention was paid to delirium, pain, mobility, postoperative complications, and renal function.
Results Analysis was carried out with 59 patients “with” and 63 “without” geriatric co-management. In the co-management group, delirium was detected significantly more often (p < 0.001), significantly lower pain intensities were measured at the time of discharge (p < 0.001), transfer ability had clearly improved more (p = 0.04), and renal function was more frequently noted (p = 0.04). No significant differences were found with respect to principal diagnoses, surgical procedures performed, complication rates, pressure ulcer and delirium incidence, operative revisions, or length of inpatient stay.
Conclusion Orthogeriatric co-management in orthopedic patients with native and periprosthetic joint infections and nontraumatic surgery appears to have positive impacts on recognition and treatment of delirium, pain management, transfer performance, and attention to renal function. Further studies should follow in order to conclusively assess the value of such co-management in orthopedic nontraumatic surgery patients.
Description of Standardized Planes and Angles for Percutaneous Supra-acetabular Screw Placement
Authors: Rüwald Julian , Ploeger Milena Maria , Hischebeth Gunnar T , Tüllmann Mareike , Roos Jonas , Gathen Martin , Kabir Koroush 
Published: January 2025

Abstract
Background Percutaneous screw fixation for pelvic fractures has become a minimally invasive alternative to an open operation. The complex anatomy of the pelvis renders this procedure challenging. The objective of this study was to assess standardized angles and dimensions of safety zones within a 3 D computed tomography model for optimal supra-acetabular screw placement.
Methods Computed tomography scans of 107 patients that suffered major trauma without showing any bone injury of the pelvis were collected. Using a software-based analysis, raw computed tomography data were transformed into 3 D models to set standardized landmarks and determine the possible insertion corridor.
Results Screws not exceeding a length of 97 mm in females and 106.4 mm in males were, in 95% of the evaluated cases, insertable without cortical bone penetration. The safety zone was 6.6 mm for females and 7.9 mm for males. Screws not exceeding these diameters were safely insertable in 95% of the cases. For the midsagittal plane, the angle was 36.4 ± 5.1 on the left and 34.7 ± 2.9 on the right (p = 0.008). For the anterior pelvic plane, the angle was 31.3 ± 4.5° on the left and 34.0 ± 4.8° on the right (p = 0.008).
Conclusions Percutaneous fixation using supra-acetabular screws is a promising method to treat simple supra-acetabular fractures. These results may improve its safe utilization and could facilitate its broader clinical application.
Deep Learning in the Detection of Rare Fractures – Development of a “Deep Learning Convolutional Network” Model for Detecting Acetabular Fractures
Authors: Erne Felix , Dehncke Daniel , Herath Steven C. , Springer Fabian , Pfeifer Nico , Eggeling Ralf , Küper Markus Alexander 
Published: January 2025

Abstract
Background Fracture detection by artificial intelligence and especially Deep Convolutional Neural Networks (DCNN) is a topic of growing interest in current orthopaedic and radiological research. As learning a DCNN usually needs a large amount of training data, mostly frequent fractures as well as conventional X-ray are used. Therefore, less common fractures like acetabular fractures (AF) are underrepresented in the literature. The aim of this pilot study was to establish a DCNN for detection of AF using computer tomography (CT) scans.
Methods Patients with an acetabular fracture were identified from the monocentric consecutive pelvic injury registry at the BG Trauma Center XXX from 01/2003–12/2019. All patients with unilateral AF and CT scans available in DICOM-format were included for further processing. All datasets were automatically anonymised and digitally post-processed. Extraction of the relevant region of interests was performed and the technique of data augmentation (DA) was implemented to artificially increase the number of training samples. A DCNN based on Med3D was used for autonomous fracture detection, using global average pooling (GAP) to reduce overfitting.
Results From a total of 2,340 patients with a pelvic fracture, 654 patients suffered from an AF. After screening and post-processing of the datasets, a total of 159 datasets were enrolled for training of the algorithm. A random assignment into training datasets (80%) and test datasets (20%) was performed. The technique of bone area extraction, DA and GAP increased the accuracy of fracture detection from 58.8% (native DCNN) up to an accuracy of 82.8% despite the low number of datasets.
Conclusion The accuracy of fracture detection of our trained DCNN is comparable to published values despite the low number of training datasets. The techniques of bone extraction, DA and GAP are useful for increasing the detection rates of rare fractures by a DCNN. Based on the used DCNN in combination with the described techniques from this pilot study, the possibility of an automatic fracture classification of AF is under investigation in a multicentre study.
Dual-Mobility Cups in Primary Total Hip Arthroplasty
Authors: Bellova Petri , Goronzy Jens , Riedel Roman , Grothe Tim , Hartmann Albrecht , Günther Klaus-Peter 
Published: January 2025

AbstractDual-mobility cups (DMCs) were introduced in France more than 40 years ago and are increasingly used not only in hip revision but also primary hip arthroplasty. Due to a simulated large-head articulation and increased jumping distance, DMCs can contribute to a high range of motion in the hip joint and reduce the risk of instability. Numerous studies have reported low dislocation rates and high survival rates in the mid-term follow-up. Nevertheless, long-term data, especially on primary hip replacement, remain limited, and the effect of recent designs and material innovations is still unclear. Therefore, primary DMCs are mainly proposed in patients at high risk for dislocation (i.e. pelvitrochanteric insufficiency, compromised spinopelvic mobility, neuromuscular disorders, obesity and femoral neck fractures). Based on a review of recently published studies referring to these indications, the current study discusses the advantages and disadvantages of DMCs.
Efficacy and Safety of Rivaroxaban and Enoxaparin for Thromboprophylaxis Among Total Hip Arthroplasty Patients: A Systematic Review and Meta-Analysis
Authors: Wang Chong , Lan Shuhua , Xie Panpan , Yang Ruifeng 
Published: January 2025

Abstract
Background Venous thromboembolism (VTE) is one of the major and potentially life-threatening complications following major orthopedic surgeries. Research evidence comparing the effectiveness of rivaroxaban and enoxaparin for thromboprophylaxis specific to total hip arthroplasty (THA) has been limited. Hence, this review was done to compare the efficacy and safety of rivaroxaban against enoxaparin for thromboprophylaxis after THA.
Materials and Methods We conducted a search in databases including Medline, EMBASE, ScienceDirect, Google Scholar, and Cochrane Library from inception until May 2021. Randomized controlled trials directly comparing the effectiveness of rivaroxaban and enoxaparin for thromboprophylaxis among patients undergoing THA were eligible for inclusion. Outcome parameters assessed were efficacy in terms of total VTE and all-cause mortality, major VTE, deep vein thrombosis, symptomatic VTE, and safety in terms of major bleeding events, clinically relevant nonmajor bleeding events, minor bleeding events, total bleeding events, drug-related adverse events, and wound infection. We performed a meta-analysis with a random effects model and reported a pooled risk ratio (RR) with a 95% confidence interval (CI).
Results Eleven studies, including 9057 participants, were analyzed. Amongst efficacy outcomes, VTE and all-cause mortality pooled an RR of 0.58 (95% CI: 0.34–0.99), major VTE pooled an RR of 0.37 (95% CI: 0.15–0.90), deep vein thrombosis pooled an RR of 0.57 (95% CI: 0.32–1.02), and symptomatic VTE pooled an RR of 0.51 (95% CI: 0.30–0.87). Amongst safety outcomes, major bleeding events pooled an RR of 1.18 (95% CI: 0.77–1.80), total bleeding events pooled an RR of 1.12 (95% CI: 0.93–1.34), drug-related adverse event pooled an RR of 0.99 (95% CI: 0.87–1.12), and wound infection pooled an RR of 1.11 (95% CI: 0.58–2.14).
Conclusion Rivaroxaban is a more efficacious drug in terms of VTE and all-cause mortality compared to enoxaparin following THA, and rivaroxaban was non-inferior in terms of safety profiles such as wound infection, bleeding, and drug-related adverse events.