bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mechanical properties of ambient cured fly ash‐slag‐based engineered geopolymer composites with different types of fibers
Authors: Li Zeya , Sheikh M. Neaz , Feng Hu , Hadi Muhammad N. S. 
Published: February 2023

AbstractIn this paper, low‐strength polyvinyl alcohol (L‐PVA) fibers, high‐strength polyvinyl alcohol (H‐PVA) fibers, and polyethylene (PE) fibers were used to prepare ambient cured fly ash‐slag‐based engineered geopolymer composites (EGC). The effects of fiber types and fiber volume fractions (1.5%, 1.75%, 2.0%, 2.25%, and 2.5%) on the compressive strength and tensile performance of EGC were evaluated. It was found that by increasing the fiber volume fraction from 1.5% to 2.5%, L‐PVA fibers had the lowest influence, whereas PE fibers had the highest influence on the compressive strength of EGC. The optimum fiber volume fractions of L‐PVA, H‐PVA, and PE fibers were 1.75%, 2.25%, and 1.5%, respectively, for EGC to achieve the best tensile performance. Scanning electron microscope (SEM) investigations showed that the bonding performance of PE fibers to the EGC matrix was higher than those of L‐PVA and H‐PVA fibers to the EGC matrix.
Long‐term reproductive effects in male rats prenatally exposed to sodium arsenite
Authors: Souza Ana Cláudia F. , Bastos Daniel S. S. , Couto‐Santos Felipe , Guimarães‐Ervilha Luiz Otávio , Araújo Larissa S. , Souza Pedro H. C. A. , Coimbra John L. P. , Oliveira Leandro L. , Guimarães Simone E. F. , Machado‐Neves Mariana 
Published: February 2023

AbstractArsenic is an environmental toxicant known to be a carcinogen and endocrine disruptor. Maternal exposure to arsenic has been associated with fetus malformation and reproductive disorders in male offspring. However, it is unclear the extent to which those effects remain during postnatal development and adulthood. Therefore, this study aimed to investigate the long‐term effects of prenatal arsenic exposure on reproductive parameters of male offspring at peripubertal and adult periods. Pregnant female Wistar rats were exposed to 0 or 10 mg/L sodium arsenite in drinking water from gestational day 1 (GD 1) until GD 21 and male pups were analyzed at postnatal day 44 (PND 44) and PND 70. We observed that some reproductive parameters were affected differently by arsenic exposure at each age evaluated. The body and reproductive organs weights, as well as testicular and epididymal morphology were strongly affected in peripubertal animals and recovered at adult period. On the other hand, the antioxidant genes expression (SOD1, SOD2, CAT and GSTK1) and the endogenous antioxidant system were affected in the testes and epididymides from both peripubertal and adult rats. Finally, an impairment in daily sperm production and in sperm parameters was observed in adult animals. Taken together, our findings show that prenatal arsenic exposure affected reproductive parameters of peripubertal and adult male rats mainly due to oxidative stress. Collectively, those alterations may be affecting fertility potential of adult animals.
Effects of zinc chloride on boar sperm quality during liquid storage at 17°C
Authors: Hu Qimeng 
Published: February 2023

AbstractObjectivesThe aim of this study was to evaluate the effects of zinc chloride (ZnCl2) at 20, 50, 100, and 200 μg/mL on the quality of seminal plasma‐free boar sperm stored at 17°C for 7 days and to explore the underlying mechanisms.MethodsBoar sperm were collected and incubated in non‐capacitation/capacitation medium to analyze sperm quality.ResultsIn the non‐capacitated state, the addition of ZnCl2 at 20 and 50 μg/mL improved the survival rate and plasma membrane integrity of boar sperm (p < 0.05). Compared to the control group, the addition of ZnCl2 significantly increased total antioxidative capacity and CuZn superoxide dismutase activity, while reducing the malondialdehyde content (p < 0.05). ZnCl2 at 100 and 200 μg/mL significantly decreased sperm motility, protein kinase A (PKA) substrate phosphorylation, and tyrosine phosphorylation. These proteins were mainly located on the mid‐pieces of the flagellum. The addition of ZnCl2 at 20 and 50 μg/mL conveyed a protective effect to boar sperm stored at 17°C. Furthermore, ZnCl2 at 100 and 200 μg/mL inhibited sperm motility via tyrosine phosphorylation, thus preventing the ‘capacitation‐like’ state. In the capacitated state, there was no change in PKA substrate phosphorylation and tyrosine phosphorylation of the mid‐pieces of the flagellum compared to the control groups, indicating that the addition of Zn2+ did not negatively affect capacitation of preserved sperm.ConclusionsZnCl2 showed protective capacity to the preservation extender used for boar sperm during the process of 17°C storage, and the optimal concentration of ZnCl2 for the preservation extender was 100 μg/mL.
The Archaeology of Forced Migration in Greece: A Layered Pedagogy
Authors: Kourelis Kostis 
Published: February 2023

AbstractHow does the academic teaching of archaeology in the United States respond to the urgent questions surrounding this migration to Europe? The ad hoc urbanism of Greece’s migrant camps offers a rich entry point for the study of contemporary migration and its relationship to historical landscapes. Since its foundation in 1830, modern Greece has experienced continuous episodes of forced migration, emigration, internal displacement, war, economic collapse, destruction, abandonment, and ruination. Its countryside is layered with migrant sites, artifacts, and memories. Starting in the seventeenth century, European intellectuals valorized the Greek landscape as an idyllic Arcadia that was central to Western civilization’s relationship to nature. Representing universal values, Greece’s antiquities stand as foils to the mutability and degeneration of modernity and form the subject of archaeology as a discipline.
Teaching Forced Displacement with Geospatial Technology in Refugee Camps: Lessons from Rwanda and Jordan
Authors: Tomaszewski Brian 
Published: February 2023

AbstractForced displacement is inherently spatial, with aspects operating at multiple scales. At the individual scale, space shapes a survivor’s experience. At the regional scale, space mediates our understanding of global processes of forced displacement and shapes our local responses to these worldwide trends. As long as there has been forced displacement, some form of geographic mapping has been used to understand, represent, and reason about forced displacement. In modern times, mapping technology comes in the form of geospatial technologies that can range from a displaced person using Google Maps on their phone to navigate in an unfamiliar environment as they migrate from their home country, to powerful geographic information systems (GISs) that drive core operations of organizations such as United Nations High Commissioner for Refugees (UNHCR), supporting countries hosting refugees and international humanitarian operations.
On the Pedagogical Value of Not Going There: Mobility, Fossil Fuel Consumption, and the Production of Refugees
Authors: Nevins Joseph 
Published: February 2023

AbstractHerein, I consider the work that long-distance travel courses do to contribute to some of the very factors that underlie “forced” and illegalized human movement across international divide. I do so by examining the ties between climate change, fossil fuel consumption, and associated inequities. I argue that the very exercise of mobility that travel courses engage in is a form of world-making; it helps produce a world of people who need refuge outside their home areas. In the end, I suggest that the exercise of immobility on the part of students and faculty concerned with forced migration can enrich the learning experience for all. It can also help to challenge the socio-ecological inequities that contribute to forced migration and the nation-state apparatuses of exclusion that limit the mobility of refugees and other people on the move.
Reading Eveline in Jakarta: Community Learning with Hazara Refugees
Authors: Gelmi Alberto , Akhlaqi Halima 
Published: February 2023

AbstractThis chapter outlines an intensive class that took place over approximately two weeks in the summer of 2018 at the Cisarua Refugee Learning Center (CRLC), a school in Western Indonesia that serves refugees and asylum seekers, many of whom are Hazaras. The class combined language and literacy instruction for ESL learners and also aimed to provide professional development for teachers in the form of metacognitive reflection on the course itself. This article argues that, in this unique scenario, the Humanities and Liberal Arts should take the lead as disciplines that teach interdisciplinarity and care for language, the powerful tool that regulates our interactions as individuals and as groups.
Learning Together: Exploring Visual and Textual Narration with Students Affected by Forced Migration
Authors: Murray Brittany 
Published: February 2023

AbstractIn the summer of 2019, Vassar hosted its New Americans Summer Program. For two weeks, eighteen high school students came together to take academic classes, engage in artistic projects, and explore life on a liberal arts college campus, where they learned about possible courses of study and prepared for higher education. Participants, who had arrived in the United States within the previous two to three years, brought with them knowledge gleaned from Afghanistan, Guatemala, Guinea, Haiti, Honduras, Rwanda, Turkmenistan, and other nations. Participants completed STEM and humanities coursework, experimented with digital storytelling and filmmaking, painted a mural with the help of a guest artist, learned about the college admissions process, and joined social activities on campus as well as weekend field trips.
Systematisches Risikomanagement für eine geplante Gasabschaltung im High-Care-Bereich eines Universitätsklinikums
Authors: Heller Axel R. , Eberlein-Gonska Maria , Held Hanns C. , Koch Thea 
Published: February 2023

Zusammenfassung
Hintergrund
Im Rahmen von Erweiterungsbaumaßnahmen am Uniklinikum Dresden war die Abschaltung der zentralen medizinischen Gasversorgung in einem Gebäude mit 3 intensivmedizinischen Teilstationen mit 22 Betten, einem OP-Trakt mit 5 OP und 6 Normalstationen mit je 28 Betten im laufenden Betrieb erforderlich. Damit bestand der Bedarf für die betroffenen Funktionseinheiten, für die Baumaßnahme eine interimistische dezentrale Gasversorgung mit Nullfehlertoleranz zu schaffen.

Methodik
Nach etablierten Verfahren der Risiko- und Fehlermöglichkeitsanalyse wurde durch den Notfall- und Katastrophenschutzbeauftragten des Klinikums eine Projektgruppe ins Leben gerufen, die einen Projektplan, eine Bedarfsabschätzung und einen Kommunikationsplan erarbeitete.

Ergebnisse
Eine Vielzahl von Risikofaktoren, für die geeignete Gegenmaßnahmen zu konzipieren waren, wurde systematisch ermittelt. Die Bedarfsabschätzung auf Basis physiologischer Parameter für die maximal 22 zu belegenden Beatmungsplätze über 4 h ergab je 26.000 l Sauerstoff und Druckluft. Sieben Einspeisungspunkte wurden mit je zwei 50-l-Flaschen Sauerstoff und Druckluft bestückt, mit einer Gesamtverfügbarkeit von je 175.000 l der beiden Gase. Je 8 weitere Flaschen waren zusätzlich in Reserve. Die Maßnahme wurde an einem Samstag ohne Elektivoperationsprogramm durchgeführt, sodass die betroffenen OP gesperrt werden konnten. Der Zeitpunkt wurde so gewählt, dass während des Nachmittagsschichtwechsels die doppelte Besetzung des Intensivpflegepersonals verfügbar war. Im Vorfeld wurden möglichst viele der Beatmungspatienten klinikintern verlegt. Neun Beatmungspatienten mussten allerdings verbleiben. Der technische Eingriff in die Gasversorgung dauerte lediglich 2 h, ohne Beeinflussung des Patientenzustands. Während der 2‑stündigen Interimsversorgung wurden auf den High-Care-Stationen 16.500 l Druckluft und 8000 l Sauerstoff verbraucht. Pro Beatmungspatient ergab sich rechnerisch ein Stundenverbrauch von 917 l Luft (15 l/min) und von 444 l Sauerstoff (7 l/min). Die vorausberechnete Menge auf Basis intensivmedizinischer Erfahrungswerte war deutlich geringer. Die 10fache Vorhaltung der Gasmenge und die vorhersehbar geringere Anzahl von Beatmungspatienten als die zugrunde gelegte Maximalbelegung haben dies mehr als kompensiert.

Schlussfolgerung
Für technische Eingriffe in Hochrisikobereichen ist eine sorgfältige Planung und Durchführung in einem effektiven Team erforderlich. Etablierte Verfahren des Projektmanagements und der Risikobewertung helfen in der Fehlervermeidung.
Einteilung und Nomenklatur der aktuellen Materialien zur Kompressionstherapie
Authors: Protz K. , Eder S. , Läuchli S. , Partsch H. , Stücker M. , Traber J. , Dissemond J. 
Published: February 2023

ZusammenfassungDie Kompressionstherapie ist seit mehreren Hunderten von Jahren ein wesentlicher Bestandteil der konservativen Therapie bei Menschen mit chronischen Wunden und Ödemen der unteren Extremitäten. Die dann eingeleitete Therapie kann in die Phasen der Entstauung, Erhaltung und Prävention unterteilt werden. Die Auswahl der jeweiligen Kompressionsversorgung orientiert sich u. a. an den Therapiephasen, dem klinischen Stadium und Symptomen, den Bedürfnissen Betroffener und deren körperlichen Fähigkeiten. Für die Kompressionstherapie steht heute eine Vielzahl an unterschiedlichen Materialien und Methoden zur Verfügung. Daher gestaltet es sich zunehmend schwieriger, einen Überblick über diese Behandlungsoptionen zu behalten, zumal die verwendete Nomenklatur der Hersteller oft nicht einheitlich ist. In dieser Übersichtsarbeit werden daher die aktuell im deutschsprachigen Raum verfügbaren Materialien und Methoden zur Kompressionstherapie mit ihren Einsatzmöglichkeiten erläutert. Zudem wird eine einheitliche Nomenklatur vorgeschlagen, auf deren Basis eine sachgerechte Dokumentation und Kommunikation aller an der Versorgung von Menschen mit Kompressionstherapie Beteiligten gewährleistet ist.
Liposome-based high-throughput and point-of-care assays toward the quick, simple, and sensitive detection of neutralizing antibodies against SARS-CoV-2 in patient sera
Authors: Streif Simon , Neckermann Patrick , Spitzenberg Clemens , Weiss Katharina , Hoecherl Kilian , Kulikowski Kacper , Hahner Sonja , Noelting Christina , Einhauser Sebastian , Peterhoff David , Asam Claudia , Wagner Ralf , Baeumner Antje J. 
Published: February 2023

AbstractThe emergence of severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) in 2019 caused an increased interest in neutralizing antibody tests to determine the immune status of the population. Standard live-virus-based neutralization assays such as plaque-reduction assays or pseudovirus neutralization tests cannot be adapted to the point-of-care (POC). Accordingly, tests quantifying competitive binding inhibition of the angiotensin-converting enzyme 2 (ACE2) receptor to the receptor-binding domain (RBD) of SARS-CoV-2 by neutralizing antibodies have been developed. Here, we present a new platform using sulforhodamine B encapsulating liposomes decorated with RBD as foundation for the development of both a fluorescent, highly feasible high-throughput (HTS) and a POC-ready neutralizing antibody assay. RBD-conjugated liposomes are incubated with serum and subsequently immobilized in an ACE2-coated plate or mixed with biotinylated ACE2 and used in test strip with streptavidin test line, respectively. Polyclonal neutralizing human antibodies were shown to cause complete binding inhibition, while S309 and CR3022 human monoclonal antibodies only caused partial inhibition, proving the functionality of the assay. Both formats, the HTS and POC assay, were then tested using 20 sera containing varying titers of neutralizing antibodies, and a control panel of sera including prepandemic sera and reconvalescent sera from respiratory infections other than SARS-CoV-2. Both assays correlated well with a standard pseudovirus neutralization test (r = 0.847 for HTS and r = 0.614 for POC format). Furthermore, excellent correlation (r = 0.868) between HTS and POC formats was observed. The flexibility afforded by liposomes as signaling agents using different dyes and sizes can hence be utilized in the future for a broad range of multianalyte neutralizing antibody diagnostics.
Graphical abstract
Variabilities in global DNA methylation and β-sheet richness establish spectroscopic landscapes among subtypes of pancreatic cancer
Authors: Szymoński Krzysztof , Lipiec Ewelina , Sofińska Kamila , Skirlińska-Nosek Katarzyna , Czaja Michał , Seweryn Sara , Wilkosz Natalia , Birarda Giovanni , Piccirilli Federica , Vaccari Lisa , Chmura Łukasz , Szpor Joanna , Adamek Dariusz , Szymoński Marek 
Published: February 2023

Abstract
Purpose
Knowledge about pancreatic cancer (PC) biology has been growing rapidly in recent decades. Nevertheless, the survival of PC patients has not greatly improved. The development of a novel methodology suitable for deep investigation of the nature of PC tumors is of great importance. Molecular imaging techniques, such as Fourier transform infrared (FTIR) spectroscopy and Raman hyperspectral mapping (RHM) combined with advanced multivariate data analysis, were useful in studying the biochemical composition of PC tissue.

Methods
Here, we evaluated the potential of molecular imaging in differentiating three groups of PC tumors, which originate from different precursor lesions. Specifically, we comprehensively investigated adenocarcinomas (ACs): conventional ductal AC, intraductal papillary mucinous carcinoma, and ampulla of Vater AC. FTIR microspectroscopy and RHM maps of 24 PC tissue slides were obtained, and comprehensive advanced statistical analyses, such as hierarchical clustering and nonnegative matrix factorization, were performed on a total of 211,355 Raman spectra. Additionally, we employed deep learning technology for the same task of PC subtyping to enable automation. The so-called convolutional neural network (CNN) was trained to recognize spectra specific to each PC group and then employed to generate CNN-prediction-based tissue maps. To identify the DNA methylation spectral markers, we used differently methylated, isolated DNA and compared the observed spectral differences with the results obtained from cellular nuclei regions of PC tissues.

Results
The results showed significant differences among cancer tissues of the studied PC groups. The main findings are the varying content of β-sheet-rich proteins within the PC cells and alterations in the relative DNA methylation level. Our CNN model efficiently differentiated PC groups with 94% accuracy. The usage of CNN in the classification task did not require Raman spectral data preprocessing and eliminated the need for extensive knowledge of statistical methodologies.

Conclusions
Molecular spectroscopy combined with CNN technology is a powerful tool for PC detection and subtyping. The molecular fingerprint of DNA methylation and β-sheet cytoplasmic proteins established by our results is different for the main PC groups and allowed the subtyping of pancreatic tumors, which can improve patient management and increase their survival. Our observations are of key importance in understanding the variability of PC and allow translation of the methodology into clinical practice by utilizing liquid biopsy testing.
Data Processing Scheme for Laser Spot Thermography Applied for Nondestructive Testing of Composite Laminates
Authors: Roemer Jakub , Khawaja Hassan , Moatamedi Mojtaba , Pieczonka Lukasz 
Published: February 2023

AbstractThis paper proposes a data processing scheme for laser spot thermography (LST) applied for nondestructive testing (NDT) of composite laminates. The LST involves recording multiple thermographic sequences, resulting in large amounts of data that have to be processed cumulatively to evaluate the diagnostic information. This paper demonstrates a new data processing scheme based on parameterization and machine learning. The approach allows to overcome some of the major difficulties in LST signal processing and deliver valuable diagnostic information. The effectiveness of the proposed approach is demonstrated on an experimental dataset acquired for a laminated composite sample with multiple simulated delaminations. The paper discusses the theoretical aspects of the proposed signal processing and inference algorithms as well as the experimental arrangements necessary to collect the input data.
Knudsen Layer Behaviour and Momentum Accommodation from Surface Roughness Modelling
Authors: Kratzer Matthew M. , Bhatia Suresh K. , Klimenko Alexander Y. 
Published: February 2023

AbstractThis work analyses the formation of the Knudsen layer in micro/nanoscale flows by linking a rough wall collision model to a continuum flow model via asymptotic matching. Expressions for the accommodation coefficients in terms of the surface characteristics are derived, allowing for boundary layer analysis of rarefied flows without the use of prior determined accommodation coefficients. This derived model, through use of the Lennard–Jones parameters for a nanoscale system, allows for a prediction of the the effective Tangential Momentum Accommodation Coefficient (TMAC) in flows against ordered nanoscale surfaces.
Do animal models of brain tumors replicate human peritumoral edema? a systematic literature search
Authors: Schramm Moritz W. J. , Currie Stuart , Lee Ming-te , Livermore Laurent J. , Solanki Sandeep P. , Mathew Ryan K. , Wurdak Heiko , Lorger Mihaela , Twelves Chris , Short Susan C. , Chakrabarty Aruna , Chumas Paul 
Published: February 2023

Abstract
Introduction
Brain tumors cause morbidity and mortality in part through peritumoral brain edema. The current main treatment for peritumoral brain edema are corticosteroids. Due to the increased recognition of their side-effect profile, there is growing interest in finding alternatives to steroids but there is little formal study of animal models of peritumoral brain edema. This study aims to summarize the available literature.

Methods
A systematic search was undertaken of 5 literature databases (Medline, Embase, CINAHL, PubMed and the Cochrane Library). The generic strategy was to search for various terms associated with “brain tumors”, “brain edema” and “animal models”.

Results
We identified 603 reports, of which 112 were identified as relevant for full text analysis that studied 114 peritumoral brain edema animal models. We found significant heterogeneity in the species and strain of tumor-bearing animals, tumor implantation method and edema assessment. Most models did not produce appreciable brain edema and did not test for observable manifestations thereof.

Conclusion
No animal model currently exists that enable the investigation of novel candidates for the treatment of peritumoral brain edema. With current interest in alternative treatments for peritumoral brain edema, there is an unmet need for clinically relevant animal models.