bluuebunny/crossref_metadata_2025_split huggingface dataset:
Deep learning-based switchable network for in-loop filtering in high efficiency video coding
Authors: Joy Helen K. , Kounte Manjunath R 
Published: April 2023

<span lang="EN-US">The video codecs are focusing on a smart transition in this era. A future area of research that has not yet been fully investigated is the effect of deep learning on video compression. The paper’s goal is to reduce the ringing and artifacts that loop filtering causes when high-efficiency video compression is used. Even though there is a lot of research being done to lessen this effect, there are still many improvements that can be made. In This paper we have focused on an intelligent solution for improvising in-loop filtering in high efficiency video coding (HEVC) using a deep convolutional neural network (CNN). The paper proposes the design and implementation of deep CNN-based loop filtering using a series of 15 CNN networks followed by a combine and squeeze network that improves feature extraction. The resultant output is free from double enhancement and the peak signal-to-noise ratio is improved by 0.5 dB compared to existing techniques. The experiments then demonstrate that improving the coding efficiency by pipelining this network to the current network and using it for higher quantization parameters (QP) is more effective than using it separately. Coding efficiency is improved by an average of 8.3% with the switching based deep CNN in-loop filtering.</span>
Epidemiologia clínica da dor músculo-esquelética
Authors: Teixeira Manoel Jacobsen , Teixeira William Gemio Jacobsen , Santos Fábio Pires de Souza , Andrade Daniel Ciampi Araujo de , Bezerra Simone Lopes , Figueiró João Bertuol , Okada Massako 
Published: April 2023

Vários estudos demonstram que as mulheres apresentam mais dor do que os homens. Entretanto, os estudos sobrelombalgia e dor torácica não são conclusivos. Em casos de dores articulares e fibromialgia existe aumento da prevalência com o progredir das idades em ambos os sexos, apesar de haver predominio nas mulheres. As síndromes dolorosas decorrentes das disfunções têmporo-mandibulares são mais comuns nas mulheres que nos homens e apresentam pico de ocorrência nas fases reprodutivas. A diferença na ocorrência da dor nos homens e nas mulheres pode ser devida a vários fatores incluindo os constitucionais, os hormonais, os cognitivos e os culturais, entre outros. O aumento da freqüência da dor com o avanço da idade, especialmente das dores articulares e da fibromialgia, sugere haver associação entre as afecções degenerativas ou acúmulo de casos de dor com o progredir da idade. A redução da freqüência de alguns casos de dor nos idosos pode ser devida à melhora das condições causais com o passar do tempo ou ao aumento da incapacidade ou da mortalidade que remove tais indivíduos das comunidades.
The Neurovasculome: Key Roles in Brain Health and Cognitive Impairment: A Scientific Statement From the American Heart Association/American Stroke Association
Authors: Iadecola Costantino , Smith Eric E. , Anrather Josef , Gu Chenghua , Mishra Anusha , Misra Sanjay , Perez-Pinzon Miguel A. , Shih Andy Y. , Sorond Farzaneh A. , van Veluw Susanne J. , Wellington Cheryl L. ,   on behalf of the American Heart Association Stroke Council; Council on Arteriosclerosis, Thrombosis and Vascular Biology; Council on Cardiovascular Radiology and Intervention; Council on Hypertension; and Council on Lifestyle and Cardiometabolic Health
Published: April 2023

Background:
Preservation of brain health has emerged as a leading public health priority for the aging world population. Advances in neurovascular biology have revealed an intricate relationship among brain cells, meninges, and the hematic and lymphatic vasculature (the neurovasculome) that is highly relevant to the maintenance of cognitive function. In this scientific statement, a multidisciplinary team of experts examines these advances, assesses their relevance to brain health and disease, identifies knowledge gaps, and provides future directions.

Methods:
Authors with relevant expertise were selected in accordance with the American Heart Association conflict-of-interest management policy. They were assigned topics pertaining to their areas of expertise, reviewed the literature, and summarized the available data.

Results:

The neurovasculome, composed of extracranial, intracranial, and meningeal vessels, as well as lymphatics and associated cells, subserves critical homeostatic functions vital for brain health. These include delivering O
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and nutrients through blood flow and regulating immune trafficking, as well as clearing pathogenic proteins through perivascular spaces and dural lymphatics. Single-cell omics technologies have unveiled an unprecedented molecular heterogeneity in the cellular components of the neurovasculome and have identified novel reciprocal interactions with brain cells. The evidence suggests a previously unappreciated diversity of the pathogenic mechanisms by which disruption of the neurovasculome contributes to cognitive dysfunction in neurovascular and neurodegenerative diseases, providing new opportunities for the prevention, recognition, and treatment of these conditions.

Conclusions:
These advances shed new light on the symbiotic relationship between the brain and its vessels and promise to provide new diagnostic and therapeutic approaches for brain disorders associated with cognitive dysfunction.
Мовна гра як вияв національної лінгвокреативності: на матеріалі галицьких паремій XIX ст.
Authors: Гнатюк [Hnatiuk] Лідія [Lidiia] Павлівна [Pavlivna] 
Published: April 2023

Language Play as a Manifestation of Linguistic Creativity (on the Material of Nineteenth-Century Galician Paroemias)
This article analyses nineteenth-century paroemias from the threevolume collection Halytsʹko-rusʹki narodni prypovidky [Galician-Ruthenian Folk Paroemias] by Ivan Franko, published in 1901–1910. The proverbs and sayings recorded in the collection indicate that in the nineteenth century Ukrainians often combined words that sound alike, which endowed them with new shades of meaning. In order to add expressivity and subtle humour, Ukrainian speakers made skilful use of rich lexico-semantic and grammatical resources. They played with transformation of homonyms, paronomasia, and metathesis of syllables or words in syntagmas. They also used synonyms and words from the same word families and they created onyms.

Gra językowa jako przejaw kreatywności językowej (na materiale galicyjskiej paremii z XIX wieku)
W artykule zanalizowano dziewiętnastowieczną paremię zamieszczoną w trzytomowym zbiorze Галицько-руські народні приповідки, którą w latach 1901–1910 opublikował Iwan Franko. Zawarte w nim przysłowia i porzekadła świadczą, że w XIX wieku Ukraińcy często łączyli wyrazy o podobnym brzmieniu, co nadawało im nowe odcienie znaczeniowe. Dla wyrażenia ekspresji i subtelnego humoru umiejętnie korzystali z bogatego zasobu leksykalno-semantycznego i gramatycznego. W grze językowej sięgali po: przekształcanie homonimów, paronomazję, przestawianie sylab lub wyrazów w syntagmach. Wykorzystywali również synonimy i wyrazy pokrewne, stosowali reinterpretację etymologiczną, tworzyli także onimy.
Wspomnienie o Profesorze Jerzym Bartmińskim (1939–2022)
Authors: Masłowska Ewa , Pazio-Wlazłowska Dorota 
Published: April 2023

In Memoriam: Professor Dr hab. Jerzy Bartmiński (1939−2022)This is an article in memory of Professor Jerzy Bartmiński, a renowned Polish philologist, ethnoliguist, folklorist and Slavist, working at the Maria Curie-Skłodowska University (since 1961), and the Institute of Slavic Studies, Polish Academy of Sciences (since 2008). Wspomnienie o Profesorze Jerzym Bartmińskim (1939–2022)Wspomnienie o Profesorze Jerzym Bartmińskim, wybitnym poloniście, etnolingwiście, folkloryście, slawiście pracującym na Uniwersytecie Marii Curie-Skłodowskiej (od 1961 roku) i w Instytucie Slawistyki Polskiej Akademii Nauk (od 2008 roku).
New Biomarkers (Endocan, Interleukin-17, and Thrombospondin-4) for the Diagnosis, Assessment of Severity, and Follow-Up of Peripheral Arterial Disease
Authors: Yazman Serkan , Depboylu Burak Can , Saruhan Ercan , Cenikli Utku , Harmandar Buğra , Arslan Kadir , İlhan Gökhan , İştar Hande 
Published: April 2023

The present study evaluated the use of endocan, interleukin-17 (IL-17), and thrombospondin-4 (TSP-4) blood levels as potential biomarkers for the diagnosis and follow-up of peripheral arterial disease (PAD). Patients with PAD (Rutherford categories I, II, and III) who were admitted between March 2020 and March 2022 for cardiovascular surgery or outpatient clinic follow-up were included. The patients ( n = 60) were divided into 2 groups: medical treatment ( n = 30) and surgical treatment ( n = 30). In addition, a control group ( n = 30) was created for comparison. Endocan, IL-17, and TSP-4 blood levels were measured at the time of diagnosis and at the first month after treatment. Endocan and IL-17 values were found to be significantly higher in both groups that underwent medical (259.7 ± 46 pg/mL, 63.7 ± 16.6 pg/mL) and surgical (290.3 ± 84.5 pg/mL, 66.4 ± 19.6 pg/mL) treatment than the control group (187.4 ± 34.5 pg/mL, 56.5 ± 7.2 pg/mL P < .001). Tsp-4 value was found to be significantly higher only in the surgical treatment group (15 ± 4.3 ng/mL) than the control group (12.9 ± 1.4 ng/mL P < .05). The decreases in endocan, IL-17, and TSP-4 levels at the first month of treatment in both groups were also significant ( P < .001). A combination of classical and these new biomarkers could be included in PAD screening, early diagnosis, severity determination, and follow-up protocols in order to provide effective assessment in clinical practice.
Testing Explanations for Skepticism of Personalized Risk Information
Authors: Waters Erika A. , Taber Jennifer M. , Ackermann Nicole , Maki Julia , McQueen Amy M. , Scherer Laura D. 
Published: April 2023

Background The promise of precision medicine could be stymied if people do not accept the legitimacy of personalized risk information. We tested 4 explanations for skepticism of personalized diabetes risk information. Method We recruited participants ( N = 356; Mage = 48.6 [ s = 9.8], 85.1% women, 59.0% non-Hispanic white) from community locations (e.g., barbershops, churches) for a risk communication intervention. Participants received personalized information about their risk of developing diabetes and heart disease, stroke, colon cancer, and/or breast cancer (women). Then they completed survey items. We combined 2 items (recalled risk, perceived risk) to create a trichotomous risk skepticism variable (acceptance, overestimation, underestimation). Additional items assessed possible explanations for risk skepticism: 1) information evaluation skills (education, graph literacy, numeracy), 2 ) motivated reasoning (negative affect toward the information, spontaneous self-affirmation, information avoidance); 3) Bayesian updating (surprise), and 4) personal relevance (racial/ethnic identity). We used multinomial logistic regression for data analysis. Results Of the participants, 18% believed that their diabetes risk was lower than the information provided, 40% believed their risk was higher, and 42% accepted the information. Information evaluation skills were not supported as a risk skepticism explanation. Motivated reasoning received some support; higher diabetes risk and more negative affect toward the information were associated with risk underestimation, but spontaneous self-affirmation and information avoidance were not moderators. For Bayesian updating, more surprise was associated with overestimation. For personal relevance, belonging to a marginalized racial/ethnic group was associated with underestimation. Conclusion There are likely multiple cognitive, affective, and motivational explanations for risk skepticism. Understanding these explanations and developing interventions that address them will increase the effectiveness of precision medicine and facilitate its widespread implementation.
The use of intelligent analysis (IA) in determining the tactics of treating patients with nephrolithiasis
Authors: Alexander Izrailevich Neymark , Boris Alexandrovich Neymark , Artem Vladimirovich Ershov , Leonid Grigoryevich Spivak , Dmitry Olegovich Korolev , Dmitry Georgievich Tsarichenko , Leonid Moiseevich Rapoport 
Published: April 2023

Introduction: The use of modern information technologies allows to increase confidence in the choice of a surgical treatment method of kidney stones, as well as to improve the quality of treatment due to an adequate combination of therapeutic techniques. Materials and methods: In our study we analyzed the treatment results of 625 patients with kidney stones. We created a register with the information on more than 50 parameters for each patient. Each example had an output parameter representing a predefined treatment strategy (extracorporeal shock-wave lithotripsy [ESWL]—1, percutaneous nephrolithotomy [PCNL]—2, pyelolithotomy or nephrolithotomy—3). The initial database served as the basis for training the neural network estimation technique. The aim of our study was to assess the possibility of using neural network algorithms in choosing a method for surgical treatment of urolithiasis. Results: A prospective study was conducted to assess the clinical effectiveness of implementing the recommendations of the system. The average number of sessions in the group using the neural network assessment technique was 1.4. Residual fragments remained at the time of discharge in seven (15.6%) patients: four in the kidney, three in the lower third of the ureter “stone path.” Inversion of therapeutic tactics—PCNL—was performed in four cases. The efficiency of the ESWL was 91.1%. The indicators of the ESWL in the comparison groups differed statistically significantly: in the second group, the efficiency was higher due to more stone fragmentation, with lower energy costs (the average number of sessions was 0.4 less). Conclusion: The presented technique can be of help for a practicing urologist to choose the optimal treatment method for each patient, thereby minimizing the risk of early postoperative complications.
Adult Psychiatric Hospitalizations in Ontario, Canada Before and During the COVID-19 Pandemic
Authors: Tanner Bryan , Kurdyak Paul , de Oliveira Claire 
Published: April 2023

Objective The impacts of the COVID-19 pandemic on psychiatric hospitalizations in Ontario are unknown. The purpose of this study was to identify changes to volumes and characteristics of psychiatric hospitalizations in Ontario during the COVID-19 pandemic. Methods A time series analysis was done using psychiatric hospitalizations with admissions dates from July 2017 to September 2021 identified from provincial health administrative data. Variables included monthly volumes of hospitalizations as well as proportions of stays <3 days and involuntary admissions, overall and by diagnosis (mood, psychotic, addiction, and other disorders). Changes to trends during the pandemic were tested using linear regression. Results A total of 236,634 psychiatric hospitalizations were identified. Volumes decreased in the first few months of the pandemic before returning to prepandemic volumes by May 2020. However, monthly hospitalizations for psychotic disorders increased by ∼9% compared to the prepandemic period and remained elevated thereafter. Short stays and involuntary admissions increased by approximately 2% and 7%, respectively, before trending downwards. Conclusion Psychiatric hospitalizations quickly stabilized in response to the COVID-19 pandemic. However, evidence suggested a shift towards a more severe presentation during this period.
Emodin Exerts its Therapeutic Effects Through Metabolic Remodeling in Severe Acute Pancreatitis-Related Intestinal Injury
Authors: Wang Minjie , Pan Chen , Deng Dawei , Xie Mingzheng , Cao Yongqing 
Published: April 2023

Background Intestinal injury caused by severe acute pancreatitis (SAP) can induce peripancreatic and systemic infection, and aggravate systemic inflammation. Emodin has demonstrated efficacy in mitigating SAP-associated intestinal injury. Although metabolites in tissues cause histopathophysiological changes, data on the mechanisms of emodin on metabolic processes remain scant. Methods The SAP-related intestinal injury rat model was induced by injection of 3.5% sodium taurocholate solution through the biliopancreatic duct. The protective effect of emodin on intestinal injury was evaluated by histologic analyses. On the other hand, we assessed the effect of emodin on metabolic remodeling in intestinal tissues using untargeted metabolomics. Results Out of the analyzed 1187 metabolites, untargeted metabolomics identified 99 differential metabolites in the intestinal tissues. Emodin significantly alleviated the inflammatory injury in the pancreas and intestines. Emodin treatment led to significant changes in bile acid metabolism, amino acid metabolism, intestinal microbiota related metabolism, and glycerol phospholipid metabolism in the intestinal tissues. In addition, using the weighted gene co-expression network analysis, we constructed emodin related metabolite–metabolite interaction network and showed that intestinal microbiota related metabolites and glycerol phospholipid metabolism were associated with emodin treatment. Glycine, LPC (0:0/22:6), Spermidine, 11β-hydroxyprogesterone, and N1-methyl-2-Pyridone-5-carboxamide may be efficient molecules after emodin treatment. Conclusion Taken together, our data demonstrated that intestinal injury caused by SAP induces an obvious metabolic disorder. Emodin exerts its therapeutic effects through metabolic remodeling.
The Longitudinal Link Between Personality and Relationship Quality in Emerging Adults: Mediation by Identity?
Authors: Grossmann Lea , Luyckx Koen , Prinzie Peter 
Published: April 2023

Intimate relationships, both romantic relationships and friendships, are of special importance for identity development in emerging adulthood. In the current study, we investigated longitudinal associations between Big Five personality traits and relationship quality (romantic relationships and friendships) and whether these associations are mediated by identity. A sample of emerging adults ( N = 372, 55% women) completed self-report questionnaires on personality and identity in 2015 ( Mage= 21.90 years, SD = 1.16) and on quality of friendships and romantic relationships 3 years later. By using MPlus, we tested the multivariate mediating effect of identity dimensions in the relationship among Big Five personality and quality of relationships. No mediation of identity dimensions was found. Extraversion predicted higher friendship quality 3 years later and exploration in depth was positively associated with friendship quality. Regarding romantic relationship quality, no significant direct or indirect effects were found. However, personality predicted multiple identity dimensions.
Shared and independent roles of CGRP and PACAP in migraine pathophysiology
Authors: Kuburas Adisa , Russo Andrew F. 
Published: April 2023

AbstractThe neuropeptides calcitonin gene-related peptide (CGRP) and pituitary adenylate cyclase-activating polypeptide (PACAP) have emerged as mediators of migraine pathogenesis. Both are vasodilatory peptides that can cause migraine-like attacks when infused into people and migraine-like symptoms when injected into rodents. In this narrative review, we compare the similarities and differences between the peptides in both their clinical and preclinical migraine actions. A notable clinical difference is that PACAP, but not CGRP, causes premonitory-like symptoms in patients. Both peptides are found in distinct, but overlapping areas relevant to migraine, most notably with the prevalence of CGRP in trigeminal ganglia and PACAP in sphenopalatine ganglia. In rodents, the two peptides share activities, including vasodilation, neurogenic inflammation, and nociception. Most strikingly, CGRP and PACAP cause similar migraine-like symptoms in rodents that are manifested as light aversion and tactile allodynia. Yet, the peptides appear to act by independent mechanisms possibly by distinct intracellular signaling pathways. The complexity of these signaling pathways is magnified by the existence of multiple CGRP and PACAP receptors that may contribute to migraine pathogenesis. Based on these differences, we suggest PACAP and its receptors provide a rich set of targets to complement and augment the current CGRP-based migraine therapeutics.
Impact of nanotechnology on conventional and artificial intelligence-based biosensing strategies for the detection of viruses
Authors: Ramalingam Murugan , Jaisankar Abinaya , Cheng Lijia , Krishnan Sasirekha , Lan Liang , Hassan Anwarul , Sasmazel Hilal Turkoglu , Kaji Hirokazu , Deigner Hans-Peter , Pedraz Jose Luis , Kim Hae-Won , Shi Zheng , Marrazza Giovanna 
Published: April 2023

AbstractRecent years have witnessed the emergence of several viruses and other pathogens. Some of these infectious diseases have spread globally, resulting in pandemics. Although biosensors of various types have been utilized for virus detection, their limited sensitivity remains an issue. Therefore, the development of better diagnostic tools that facilitate the more efficient detection of viruses and other pathogens has become important. Nanotechnology has been recognized as a powerful tool for the detection of viruses, and it is expected to change the landscape of virus detection and analysis. Recently, nanomaterials have gained enormous attention for their value in improving biosensor performance owing to their high surface-to-volume ratio and quantum size effects. This article reviews the impact of nanotechnology on the design, development, and performance of sensors for the detection of viruses. Special attention has been paid to nanoscale materials, various types of nanobiosensors, the internet of medical things, and artificial intelligence-based viral diagnostic techniques.