bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluating resistance of potato cultivars to powdery scab and transcriptome analysis under the stress of Spongospora subterranea
Authors: Liu Xia , Yang Yanli , Huang Xun 
Published: July 2023

Abstract

Spongospora subterranea f. sp. subterranean causes powdery scab of potato and can result in significant losses to the production. In searching strategies of disease control, 22 potato cultivars were collected and screened for assessing the resistance to powdery scab under field conditions from 2014 to 2018 in Yunnan, China. Each variety was planted with 10 plants in each of three plots. Resistance of potato was evaluated by measuring yield, disease incidence and disease index. Resistance performance was evaluated through the 5-year study period. Results showed that varieties with high level of powdery scab resistance included Mira, Lishu 6, Lishu 12, S10-843, Xuanshu 5, Lishu 1105, Lishu 14, Xuanshu 6, Huishu 9 and Yunshu 505. Yunshu 401, Qingshu 9, Hezuo 88 and S10-277 were susceptible to powdery scab. The transcriptome analysis of resistant variety Mira and susceptible variety Cooperation-88(S88) under the stress of Spongospora subterranea was carried out to explore the genes involved in regulating the resistance of powdery scab.
Replacing the unsustainable and wild-caught fishmeal with field cricket (Gryllus bimaculatus) meal in Catla (Catla catla) fry diet: Effect for growth, in vivo digestibility, carcass composition histopathological alterations and disease tolerance
Authors: Perera G. S. Champika , Afridin M. R. , Adikari A. M.A.N. , Heenatigala P. P.M. , Maduka K. L.W.T. , Dunusinghe S.B.K. 
Published: July 2023

Abstract

Insect meal has been identified as one of the cutting-edge alternatives to substitute fishmeal (FM) in aquafeeds. However, the potential of FM replacing with field cricket meal (FCM) related to Calta catla fry stage has yet to be researched. Therefore, an eight-week experiment was designed to evaluate the performance of C. catla fry (0.22 ± 0.04 g/fish). The protein content of the FM of the control feed (0FCM) was replaced with 35% (35FCM), 70% (70FCM), and 100% (100FCM) of FCM. All the fish were hand-fed by respective research diets 5% of the body weight twice daily. Results showed that FCM could replace wild-caught fishmeal (67.1 % crude protein) without adversely affecting growth performance, carcass composition, liver functions, and disease tolerance. Though in vivo protein digestibility significantly decreased (P<0.05) when the FCM percentage increased in the feed, it did not affect the performance of the fish. Therefore, FCM could be used to prepare fish-free feed in the C. catla fry stage. However, optimum technical know-how should be identified to certify the accessible and economically viable mass-scale production of FCM.
Development and validation of a risk prediction model for cefoperazone/sulbactam-related coagulation disorders in Chinese inpatients – A case-control study
Authors: Fu An , Ge Feng , Wang Yanwei , Guo Haili , Zhu Man , Li Shu , Gao Ao , Li Chao , Lu Jingchuan , Guo Daihong 
Published: July 2023

Abstract
Background and aim: Long-term use of cefoperazone/sulbactam (CPZ/SAM) may lead to vitamin K-dependent coagulation dysfunction which is significantly associated with increased risks of major bleeding and death. However, there is a lack of prediction models estimating the risk for this adverse drug reaction. This study aimed at developing and internally validating a risk prediction model for coagulation-related adverse reactions in Chinese inpatients treated with CPZ/SAM.
Methods: A case-control study was conducted in 11,092 adult inpatients admitted to our hospital from 2020 to 2021. We selected patients reporting coagulation-related adverse reactions through the Adverse Drug Events Active Surveillance and Assessment System-2 developed by our team. The final predictors were obtained by using the Least Absolute Shrinkage and Selection Operator (LASSO) algorithm. The prediction model was visualized as a static nomogram and a web-based dynamic nomogram. Internal validation and calibration were performed using bootstrap enhanced procedure with 1000 resampling.
Results: We found 215 coagulation-related adverse reactions (5.1%) in 4212 patients treated with CPZ/SAM. A final population of 208 cases and 624 controls was considered for model development and validation. Malnutrition, renal insufficiency, parenteral nutrition, longer treatment duration and red blood cell count were identified as final predictors. There is a nonlinear relationship between treatment duration and coagulation disorder. The model shows good discrimination and calibration, with the validated area under the receiver operating characteristic curve (AUROC)being 0.739 (0.699-0.779), p for Hosmer-lemeshow more than 0.05 and Brier score being 0.152. The decision curve analysis reveals that the net benefit of the model is higher, compared with the hypothesis that coagulopathy occurs in all patients with medication or no coagulopathy occurs.
Conclusions: The nomogram model quantifies the risk for coagulation-related adverse reactions in Chinese inpatients treated with CPZ/SAM, supporting individual assessment and interventions to mitigate the risk.
HERPUD1 as a potential prognostic biomarker in lung cancer and association with migration and invasion
Authors: Xiao Di , Zeng Xingruo , He Hengjing , Jamal Muhammad , Zhang Chengjie , Zhang Xiaoyu , Xie Songping , Zhang Qiuping 
Published: July 2023

Abstract
Lung adenocarcinoma (LUAD) is the most prevalent type of lung cancer with unfavorable prognosis. Endoplasmic reticulum (ER) stress and the tumor immune microenvironment (TME) contribute to cancer progression. However, the role of ER stress and TME in LUAD remains poorly understood. Utilizing bioinformatics analysis, we identified HERPUD1 as a promising candidate gene among ER stress-related genes. HERPUD1 was found down-regulated in lung cancer tissues compared to normal tissues, with low expression HERPUD1 serving as a poor prognostic indicator. Immunofluorescence analysis indicated the subcellular localization of HERPUD1 within the cytoplasm, ER and plasma membrane. Cell functional experiments indicated that HERPUD1 overexpression significantly inhibited lung cancer cells proliferation and epithelial mesenchymal transformation (EMT). To further investigate the underlying mechanisms of HERPUD1 in LUAD, we performed GO and KEGG enrichment analyses. These analyses unveiled that upregulated HERPUD1 inhibited the JAK2/STAT3 pathway. Furthermore, immune infiltration analyses showed that a positive correlation between HERPUD1 and B cells, CD8 T cells and NK cells. Chemokine analysis showed that HERPUD1 may recruit DCs, T cells and monocytes/macrophages, and reduce the polarization of macrophages and neutrophils. Notably, high HERPUD1 expression indicated favorable chemotherapy and immunotherapy response after immune checkpoint blockade treatment. Collectively, our findings shed light on the critical role of ER stress in the context of LUAD, emphasizing the significance of HERPUD1 as a prospective therapeutic target and prognostic biomarker in LUAD.
The main forest species encountered in southern and central Benin, west Africa
Authors: Gorgias AÏKPON , Kourouma KOURA , Jean GANGLO C. 
Published: July 2023

Abstract
Benin is a West African country with significant biodiversity resources. In this regard, research work is expected in order to better discover and document the country's biodiversity. This dataset provides information on the main forest species found in southern and central Benin, West Africa. These species are characteristic of forests and above all are of particular interest both to populations and to managers of protected areas. Field collections were initiated in 2007 as part of natural forest inventory work. The data collected has been completed by various field works that followed this work on forest species in southern Benin. The latest version of the dataset is publicly and freely accessible on the Gbif website at the address https://www.gbif.org/dataset/aff3a10a-a86b-4eff-98e4-d63f92fd6f7e.
Land suitability analysis for solar power plant using satellite imagery processing and GIS, Ardabil, Iran
Authors: Hasanzadeh Meysam , Kamran Khalil Valizadeh , Feizizadeh Bakhtiar , Mollabashi Sanam Hassanzadeh 
Published: July 2023

Abstract

Fossil fuel emissions have caused immense harm to the environment, making renewable energy sources like solar power essential. However, finding the optimal location for a solar power plant requires multi-criteria decision making (MCDM) due to various factors influencing the selection process. This study used the AHP method to weigh criteria such as GHI, Temperature, Elevation, Slope, Land cover, Distance from city, and Distance from road. The layers created from satellite imagery were combined using algebraic sums to produce a final map with 9 classes The analysis showed that class 9 has the most desirable values for each criterion, indicating the most suitable regions for a solar power plant. The results of the study have identified the southern and some central regions of Ardabil province as being the most suitable locations for the construction of a solar power plant. These regions have been found to have favorable values for the criteria studied, indicating a higher potential for solar energy generation. Based on the criteria assigned to class 9, the best lands have been identified, occupying a total area of 3085 hectares. This area represents approximately 0.17% of the total area of Ardabil province. These findings highlight the importance of careful site selection for solar power plants to ensure maximum efficiency and sustainability.
Effect of Household Packaging on the Antioxidant Parameters of the Organic and Conventional Cucumis Sativus L. : a Comparative Analysis
Authors: Das Suryatapa , Chatterjee Annalakshmi , Pal Tapan Kumar 
Published: July 2023

Abstract

Organic foods are becoming popular for their health benefits consumers perceived. But proper storage of organic fresh produce is essential to preserve the vital nutrients to sustaining health benefit. The present study was framed to show the effect of domestic packaging on antioxidant and antioxidant status of organic and conventional Cucumis sativus L. stored at different temperatures. The organic and conventional Cucumis were stored without any packaging, in Polypropylene (PP) Container, Low Density Polyethylene(LDPE) Zipper bag, and Cling film wrap at ambient temperature (250C) and low (4 0C) for 3 and 7 days. The ascorbic acid content, total carotenoids, total polyphenols, total flavonoids, tannin contents, and DPPH, ABTS, and FRAP antioxidant capacities were estimated. Results showed that the ascorbic acid, total carotenoids, tannin, and flavonoids were reduced during storage. The DPPH and FRAP antioxidant capacities were reduced significantly. Therefore, packaging at ambient and low temperatures creates a modified atmosphere within it, thereby can be considered as a devising strategy to preserve antioxidants in organic and conventional Cucumis at domestic level.
Differential Neurodevelopmental Trajectories in Patients With autism spectrum disorders and developmental language disorders: A large-sample study from China
Authors: Liu Zhimei , Zou Liye , Chen Aiguo , Herold Fabian , Taylor Alyx , Yu Qian , Chen Minhua , Wei Rongmei , Cai Kelong , Liu Yuexin , Chen Wei , Li Jinming 
Published: July 2023

Abstract
In children, both autism spectrum disorder (ASD) and developmental language disorder (DLD) are characterized by serious deficits in language development and have a certain overlap in their symptoms, it is often difficult to reach a clear diagnosis. In this study 3219 children with ASD and DLD were evaluated using the Gesell Developmental Diagnostic Scale (GDDS) and the Childhood Autism Rating Scale (CARS). We observed Children with ASD exhibited a lower score in five domains. And the CARS score shows negative low to moderate correlation with the five domains of the GDDS. Based on our findings, we deduce that GDDS combined with CARS assessment can be helpful for early screening and differential diagnosis of children with ASD and DLD.
18F-FDG PET radiomics-based machine learning model for differentiating pathological subtypes in locally advanced cervical cancer
Authors: Liu Huiling , Lao Mi , Chang Cheng , Zhang Yalin , Yin Yong , Wang Ruozheng 
Published: July 2023

Abstract
Purpose
To determine diagnostic performance of 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) and computed tomography (CT) radiomics-based machine learning (ML) for classification of cervical adenocarcinoma (AC) and squamous cell carcinoma (SCC).
Methods
A total of 195 patients with locally advanced cervical cancer were enrolled in this study, and randomly allocated to training cohort (n = 136) and validation cohort (n = 59) in a ratio of 7:3. Radiomics features were extracted from pretreatment 18F-FDG PET/CT and selected by the Pearson correlation coefficient and the least absolute shrinkage and selection operator regression analysis. Six ML classifiers were trained and validated, and the best-performing classifier was selected based on accuracy, sensitivity, specificity, and area under the curve (AUC). The performance of different models was assessed and compared using the DeLong test.
Results
Five PET and one CT radiomics features were selected and incorporated into the ML classifiers. The PET radiomics model constructed based on the lightGBM algorithm had an accuracy of 0.915 and an AUC of 0.851 (95% CI, 0.715–0.986) in the validation cohort, which were higher than that of the CT radiomics model (accuracy: 0.661; AUC: 0.513 [95% CI, 0.339–0.688]). The DeLong test revealed no significant difference in AUC between the combined radiomics model and the PET radiomics model in both the training cohort (P = 0.347) and the validation cohort (P = 0.776).
Conclusions
The 18F-FDG PET radiomics model can be used as a clinically applicable tool for differentiating pathological subtypes in patients with locally advanced cervical cancer.
Elastic solids with strain-gradient elastic boundary surfaces
Authors: Rodriguez Casey 
Published: July 2023

Abstract

Recent works have shown that in contrast to classical linear elastic fracture mechanics, endowing crack fronts in a brittle solid with Steigmann-Ogden surface elasticity yields a model that predicts bounded strains at the crack tips for plane-strain problems. However, a logarithmic singularity is still present in general for anti-plane shear (mode-III fracture) even when Steigmann-Ogden surface elasticity is incorporated.
Motivated by obtaining a model of brittle fracture capable of predicting bounded strains for all modes of loading, we formulate an exact general theory of a bulk solid containing a boundary surface with strain-gradient surface elasticity. For planar reference surfaces parameterized by flat coordinates, the form of surface elasticity reduces to that introduced by Hilgers and Pipkin, and when the surface energy is independent of the surface gradient of the stretching, the theory reduces to that of Steigmann and Ogden. We give a full discussion of material symmetry using Murdoch and Cohen's extension of Noll's theory. We present a model quadratic surface energy that incorporates resistance to geodesic distortion, satisfies strong ellipticity, and requires the same material constants found in the Steigmann-Ogden theory.
Finally, we derive and apply the linearized theory to mode-III fracture in an infinite plate. We prove that there always exists a unique classical solution to the governing integro-differential equation, and in contrast to using Steigmann-Ogden surface elasticity, our model is consistent with the linearization assumption in predicting finite stresses and strains at the crack tips.
Early development of Acacia longifolia is more severely impacted by water and nutrient stress in invasive than native seedlings
Authors: Vicente Sara , Condessa Mónica , Trindade Helena , Roux Johannes J. Le , Máguas Cristina 
Published: July 2023

Abstract

The legume Acacia longifolia (Andrews) Willd. is native to southeast mainland Australia and Tasmania and has two described subspecies: A. l. ssp. longifolia and A. l. ssp. sophorae. The species has been introduced around the world and is considered invasive in several Mediterranean-type climate regions, including in South America, South Africa, and southern Europe. Previous studies comparing native and invasive populations of A. longifolia have focused on its reproductive ecology and population genetics, and little information exists on the species’ early life development and how abiotic factors influence it. Here, we performed a glasshouse experiment to compare the phenotypic responses of native and invasive (in Portugal) A. longifolia seedlings to different levels of water and nutrient availability. We found that seedlings of both subspecies responded similarly to different water and nutrient availability conditions in terms of biomass accumulation, root length, number of phyllodes, phyllode water content, and root:shoot ratio. However, compared to native seedlings, invasive seedlings had limited capacities for stress responses. We found that invasive seedlings had lower drought tolerance than native seedlings, and thus the speed of invasion by A. longifolia into drier parts of Portugal may be hindered. Our results also hint of a possible role of seed “imprinting” in this species’ early growth responses, resulting in different resource allocation strategies such as favouring early growth and development over drought resistance in the invaded range. Further studies are required to better understand the species’ abiotic stress responses at the intraspecific level and their relation to its invasiveness.
Predicting Type 2 Diabetes Mellitus Using Patients’ Clinical Symptoms, Demographic Features and Knowledge of Diabetes
Authors: Ojurongbe Taiwo Adetola , Afolabi Habeeb Abiodun , Oyekale Adesola , Bashiru Kehinde Adekunle , Ayelagbe Olubunmi , Ojurongbe Olusola , Abbasi Saddam Akber , Adegoke Nurudeen A. 
Published: July 2023

Abstract
Background: Type 2 diabetes is often undiagnosed until complications arise, which highlights the importance of health checkups. However, certain populations exhibit low adherence to these checkups, largely due to differences in socioeconomic constraints, financial capacity, and variations in self-care and routine medical habits. Given these circumstances, the urgency of developing effective predictive tools for type 2 diabetes becomes clear.
Methods: To address this, we routinely collected health checkup data from patients with diabetes and used their clinical symptoms, demographics, and diabetes knowledge to predict the disease onset. Data from 444 Nigerian patients were used to develop a predictive model, with 80% of the dataset selected for training and the remaining 20% for testing.
Results: Multivariable penalised logistic regression, with an AUC of 98% for the training set and 93% for the test set, was used to predict diabetes type. The model included fasting blood glucose (FBS), waist-hip ratio (WHR), triglycerides (TG), and catalase as informative features. Increased odds ratios of type 2 diabetes were associated with FBS (adjusted odd ratio (AOR) = 1.25; 95% confidence interval (CI) = 1.22 - 1.28, p-value < 0.0001), WHR (AOR = 1.24; 95% CI = 1.21-1.27, p-value < 0.0001), and TG (AOR = 1.12, 95% CI= 1.08-1.16, p-value <0.0001). In contrast, a decreased odd ratio of type 2 diabetes was associated with catalase (AOR = 0.85; 95% CI= 0.83-0.88, p-value < 0.0001).
Conclusion: Our study revealed associations between clinical symptoms and type 2 diabetes. It emphasises the importance of early diagnosis and helps in accurately predicting diabetes risk. A web-based application is provided to facilitate the early identification of at-risk individuals, thereby potentially alleviating health complications and bridging the care gap resulting from inconsistent health checkups.
Correlation between Adolescent Knowledge of Sunscreen Pollution and Sunscreen Habits
Authors: Joseph Aidan 
Published: July 2023

Abstract
Sunscreen Pollution is described as the entrance of sunscreen products into waterways thereby polluting them. Sunscreens have the potential to harm numerous aquatic organisms which have impacts on coastal communities. It is generally accepted that micron-sized inorganic sunscreens are less harmful than other types, however it is unknown to what extent this is recognized by adolescents and whether this knowledge has any relation with their choice of sunscreen. A survey was adapted from Casas-Béltran et al and modified to resolve this. This was administered to 3 high schools on Long Island, New York. Results indicated that adolescents using micron-sized inorganic sunscreens were more knowledgeable about sunscreen pollution than those who used organic sunscreens and those who did not apply sunscreen (p = .046, p = .045). Also a relative minority of participants indicated that they knew sunscreens were harmful to aquatic wildlife (10/62). Additionally, it was estimated 0.0279 tons of sunscreen were discharged yearly during the summertime by adolescents into waterways surrounding Long Island which is a large figure. These findings suggest that further education of the issue of sunscreen pollution and what the least harmful sunscreens are may lead to more micron-sized inorganic sunscreen use and lessen the effects on the environment.