bluuebunny/crossref_metadata_2025_split huggingface dataset:
Initial assessment of multi-compound antineoplastic drug surface contamination in Argentinean healthcare centers: Insights into occupational exposures in South America
Authors: Speranza Eric D , Jeronimo Matthew , Colombo Manuel 
Published: July 2023

Introduction Antineoplastic drug contamination can result in severe health effects for healthcare workers exposed to them. Despite the worldwide growing concern regarding these drugs and sustained monitoring efforts in developed countries, there is almost no data about surface contamination levels in Argentina, in particular, and South America, in general. Methods Antineoplastic drug contamination was measured in three Argentinean public hospitals (pharmacy and daycare center areas) by surface wiping and liquid chromatography coupled with tandem mass spectrometry. Results and Discussion Eleven drugs were detected, in 51 of 58 sampled surfaces, in variable concentrations from 0.00064 to 7.3 ng cm−2, with cyclophosphamide, gemcitabine, and paclitaxel as the most prevalent drugs. This highly variable antineoplastic distribution reflects differences in facility layout, number of patients, antineoplastic drug use, etc., at each hospital. Values exceeding the 1 ng cm−2 threshold were detected in 13 surfaces of the two hospitals handling the largest amounts of antineoplastic drugs. The cyclophosphamide 75th percentile averaged 0.030 ng cm−2 comparable to the high values reported more than 10 years ago for developed countries, emphasizing the potential of reducing antineoplastic contamination by implementing routine monitoring and improved cleaning and handling procedures. Conclusion This study is the first survey of multi-compound surface antineoplastic contamination in Argentinean (and South American) hospitals, providing a baseline against which future studies can be compared. Widespread antineoplastic contamination has been detected on numerous surfaces, with concentrations surpassing suggested threshold exposure levels (1 ng cm−1) for some surfaces in two of the sampled hospitals.
Do the Clinical Characteristics of Lipomas Influence the Incision Length During Minimal Incision Extraction?
Authors: Kang Da-Hyun , Lew Bark-Lynn , Kwon Soon-Hyo 
Published: July 2023

Background Minimal incision extraction technique is widely accepted for the surgical removal of lipomas, but no consensus for the incision length has been made yet. Objective To investigate the clinical characteristics of lipomas which affect the minimal incision length during the minimal incision extraction. Methods We retrospectively analyzed 50 patients who underwent minimal incision extraction for 55 medium-sized (3-5 cm) or large lipomas (> 5 cm) between March 2020 and May 2022. If the mass is not fully dissected, or adequate visual field for hemostasis was not provided through the initial one-third incision, the incision was extended to the minimal extent. Results There were 33 males and 17 females with a mean age of 53.5 ± 12.7 years. There was no statistical difference in the minimal % incision length, defined as [(incision length) / (tumor diameter)] x 100, between the medium-sized ( n = 31) and large lipomas ( n = 24). Lipomas of the long incision group (minimal % incision length ≥66.7%, n = 21) had a higher frequency of head and neck location than lipomas of the short incision group (minimal % incision length <66.7%, n = 34) (odds ratio = 14.5, P < .05). However, no association was found between the tumor diameter or depth and the minimal % incision length. The occurrence of postoperative complications was not associated also ( P = .296). Conclusion The minimal % incision length for lipoma removal does not show statistical difference between medium-sized and large lipomas, and is affected by its anatomical location, but not by tumor diameter or depth.
Sound contribution of the low frequency underwater noise radiated from a suspension bridge
Authors: Song Xiaodong , Lu Wei , Xiong Wen , Cai CS 
Published: July 2023

For river crossing bridges, the vehicle-induced vibration can be transmitted to the bridge tower and foundation system. This vibration induced low frequency underwater noise radiation can cause great harm to aquatic organisms. A river crossing suspension bridge was selected to study the sound contribution and spatial distribution of the underwater noise. A bridge-sediment coupling finite element model was developed, and the vehicle-bridge-sediment interaction analysis was conducted to investigate the dynamic response of the coupling system. An acoustic finite element model was built to predict the underwater noise radiated from the tower and sediment, and the noise contribution of these two sound sources was compared. The research shows that the noise radiated from the bridge tower and the sediment is below 6.3 Hz, and the peak frequency is around 3.15 Hz. The noise radiated from bridge tower only has a larger contribution to the total noise level in its vicinity than the sediment, especially around the water surface. In other space, the noise generated through the sediment vibration plays a dominant role in the total noise. The radiated noise from the tower has lateral directivity, and the directivity of the sediment radiation is similar to the point sound source.
X-ray and MR Contrast Bearing Nanoparticles Enhance the Therapeutic Response of Image-Guided Radiation Therapy for Oral Cancer
Authors: Sharma Gayatri , Razeghi Kondelaji Mir Hadi , Sharma Guru P. , Hansen Christopher , Parchur Abdul K. , Shafiee Shayan , Jagtap Jaidip M. , Fish Brian , Bergom Carmen , Paulson Eric , Hall William A. , Himburg Heather A. , Joshi Amit 
Published: July 2023

Introduction Radiation therapy for head and neck squamous cell carcinoma is constrained by radiotoxicity to normal tissue. We demonstrate 100 nm theranostic nanoparticles for image-guided radiation therapy planning and enhancement in rat head and neck squamous cell carcinoma models. Methods PEG conjugated theranostic nanoparticles comprising of Au nanorods coated with Gadolinium oxide layers were tested for radiation therapy enhancement in 2D cultures of OSC-19-GFP-luc cells, and orthotopic tongue xenografts in male immunocompromised Salt sensitive or SS rats via both intratumoral and intravenous delivery. The radiation therapy enhancement mechanism was investigated. Results Theranostic nanoparticles demonstrated both X-ray/magnetic resonance contrast in a dose-dependent manner. Magnetic resonance images depicted optimal tumor-to-background uptake at 4 h post injection. Theranostic nanoparticle + Radiation treated rats experienced reduced tumor growth compared to controls, and reduction in lung metastasis. Conclusions Theranostic nanoparticles enable preprocedure radiotherapy planning, as well as enhance radiation treatment efficacy for head and neck tumors.
Spatial distribution and driving factors of the associations between temperature and influenza-like illness in the United States: a time-stratified case-crossover study
Authors: Yang Yongli , Lian Jiao , Jia Xiaocan , Wang Tianrun , Fan Jingwen , Yang Chaojun , Wang Yuping , Bao Junzhe 
Published: July 2023

Abstract
Background
Several previous studies investigated the associations between temperature and influenza in a single city or region without a national picture. The attributable risk of influenza due to temperature and the corresponding driving factors were unclear. This study aimed to evaluate the spatial distribution characteristics of attributable risk of Influenza-like illness (ILI) caused by adverse temperatures and explore the related driving factors in the United States.

Methods
ILI, meteorological factors, and PM2.5 of 48 states in the United States were collected during 2011–2019. The time-stratified case-crossover design with a distributed lag non-linear model was carried out to evaluate the association between temperature and ILI at the state level. The multivariate meta-analysis was performed to obtain the combined effects at the national level. The attributable fraction (AF) was calculated to assess the ILI burden ascribed to adverse temperatures. The ordinary least square model (OLS), spatial lag model (SLM), and spatial error model (SEM) were utilized to identify driving factors.

Results
A total of 7,716,115 ILI cases were included in this study. Overall, the temperature was negatively associated with ILI risk, and lower temperature gave rise to a higher risk of ILI. AF ascribed to adverse temperatures differed across states, from 49.44% (95% eCI: 36.47% ~ 58.68%) in Montana to 6.51% (95% eCI: -6.49% ~ 16.46%) in Wisconsin. At the national level, 29.08% (95% eCI: 27.60% ~ 30.24%) of ILI was attributable to cold. Per 10,000 dollars increase in per-capita income was associated with the increment in AF (OLS: β = -6.110, P = 0.021; SLM: β = -5.496, P = 0.022; SEM: β = -6.150, P = 0.022).

Conclusion
The cold could enhance the risk of ILI and result in a considerable proportion of ILI disease burden. The ILI burden attributed to cold varied across states and was higher in those states with lower economic status. Targeted prevention programs should be considered to lower the burden of influenza.
Prognostic nomograms for gastric carcinoma after D2 + total gastrectomy to assist decision-making for postoperative treatment: based on Lasso regression
Authors: Li Yifan , Bai Min , Gao Yuye 
Published: July 2023

AbstractObjectiveThis study aimed to establish novel nomograms that could be used to predict the prognosis of gastric carcinoma patients who underwent D2 + total gastrectomy on overall survival (OS) and progression-free survival (PFS).MethodsLasso regression was employed to construct the nomograms. The internal validation process included bootstrapping, which was used to test the accuracy of the predictions. The calibration curve was then used to demonstrate the accuracy and consistency of the predictions. In addition, the Harrell’s Concordance index (C-index) and time-dependent receiver operating characteristic (t-ROC) curves were used to evaluate the discriminative abilities of the new nomograms and to compare its performance with the 8th edition of AJCC-TNM staging. Furthermore, decision curve analysis (DCA) was performed to assess the clinical application of our model. Finally, the prognostic risk stratification of gastric cancer was conducted with X-tile software, and the nomograms were converted into a risk-stratifying prognosis model.ResultsLASSO regression analysis identified pT stage, the number of positive lymph nodes, vascular invasion, neural invasion, the maximum diameter of tumor, the Clavien–Dindo classification for complication, and Ki67 as independent risk factors for OS and pT stage, the number of positive lymph nodes, neural invasion, and the maximum diameter of tumor for PFS. The C-index of OS nomogram was 0.719 (95% CI: 0.690–0.748), which was superior to the 8th edition of AJCC-TNM staging (0.704, 95%CI: 0.623–0.783). The C-index of PFS nomogram was 0.694 (95% CI: 0.654–0.713), which was also better than that of the 8th edition of AJCC-TNM staging (0.685, 95% CI: 0.635–0.751). The calibration curves, t-ROC curves, and DCA of the two nomogram models showed that the prediction ability of the two nomogram models was outstanding. The statistical difference in the prognosis between the low- and high-risk groups further suggested that our model had an excellent risk stratification performance.ConclusionWe reported the first risk stratification and nomogram for gastric carcinoma patients with total gastrectomy in Chinese population. Our model could potentially be used to guide treatment selections for the low- and high-risk patients to avoid delayed treatment or unnecessary overtreatment.
Serological investigation of SARS-CoV-2 infection in patients with suspect measles, 2017–2022
Authors: Bianchi Silvia , Fappani Clara , Gori Maria , Canuti Marta , Colzani Daniela , Monti Maria Cristina , Torriani Camilla , Raviglione Mario C. , Zuccotti Gianvincenzo , Tanzi Elisabetta , Amendola Antonella 
Published: July 2023

Abstract
Background
Several studies suggested that SARS-CoV-2 was already spreading worldwide during the last months of 2019 before the first outbreak was detected in Wuhan, China. Lombardy (Northern Italy) was the first European region with sustained SARS-CoV-2 transmission and recent investigations detected SARS-CoV-2-RNA-positive patients in Lombardy since late 2019.

Methods
We tested for anti-SARS-CoV-2 IgG all serum samples available in our laboratory (N = 235, collected between March 2017 and March 2022) that we received within the framework of measles/rubella surveillance from measles and rubella virus-negative patients.

Results
Thirteen of 235 samples (5.5%) were IgG-positive. The positivity rate increased starting in 2019 and was significantly different from the expected false positive rate from 2019 onwards. Additionally, in 2019 the percentage of IgG-positive patients was significantly lower among SARS-CoV-2 RNA-negative patients (3/92) compared to SARS-CoV-2 RNA-positive patients (2/7, p = 0.04). The highest percentage of IgG positivity in the pre-pandemic period was recorded during the second half of 2019. This coincided with an increase in negativity for measles and a widening of the peak of the number of measles discarded cases per 100,000 inhabitants, indicating a higher-than-normal number of measles-negative patients experiencing fever and rash. This also coincided with the first patient positive for SARS-CoV-2 RNA (September 12th, 2019); this patient was also positive for anti-SARS-CoV-2 IgG and IgM.

Conclusions
Although the number of samples was low and one cannot conclusively establish that the virus started circulating in Lombardy around September 2019, our findings should stimulate similar research investigating the possibility of undetected SARS-CoV-2 pre-pandemic circulation.
Feasibility of 2-dimensional speckle tracking echocardiography strain analysis of the right ventricle with trans-thoracic echocardiography in intensive care: a literature review and meta-analysis
Authors: McErlane James , Shelley Ben , McCall Philip 
Published: July 2023

Abstract
Objectives
To identify variables that affect the feasibility of 2-dimensional right ventricular speckle tracking echocardiography (RV-STE) in the intensive care unit.

Background
Trans-thoracic echocardiography (TTE) of the right ventricle is challenging. RV-STE is a novel echocardiography method thought to measure global RV function more fully than conventional TTE parameters. The feasibility of RV-STE in ICU populations has not been well described, and variables influencing RV-STE in ICU have not been investigated. This study aimed to address this.

Methods
A literature review using Ovid MEDLINE(R) was undertaken. We performed meta-analysis with subgroup analysis of; RV-STE type (RV free-wall [RVFWLS] versus RV global longitudinal strain [RVGLS]), study design (prospective versus retrospective), coronavirus disease-19 (COVID-19) study or not, and strain software used. This was followed by meta-regression of proportion of invasive mechanical ventilation (IMV), with and without COVID-19 studies as a co-variate.

Results
Eleven relevant studies from the literature search were identified, reporting an overall feasibility of RV-STE of 83.3% (95%CI 74.6–89.4%). Prospective study design was associated with higher feasibility compared with retrospective studies (p = 0.02). There were no statistical differences on univariate analysis between RVFWLS versus RVGLS, COVID-19 study or not, or strain software used. Meta-regression with COVID-19 study as a covariate demonstrated that higher proportions of IMV were significantly associated with worse feasibility (p = 0.04), as were COVID-19 studies (p < 0.01).

Conclusions
We have identified three variables associated with poor feasibility; retrospective study design, COVID-19 studies, and proportion of IMV. A prospective study design should be viewed as gold standard to maximise RV-STE feasibility.
Non-Isocyanate Polyurethane Synthesis by Polycondensation of Alkylene and Arylene Bis(fluoroalkyl) Bis(carbonate)s with Diamines
Authors: Hosokawa Sasuga , Nagao Akihiro , Hashimoto Yuka , Matsune Ayako , Okazoe Takashi , Suzuki Chitoshi , Wada Hiroshi , Kakiuchi Toshifumi , Tsuda Akihiko 
Published: July 2023

Abstract
Alkylene and arylene bis(fluoroalkyl) bis(carbonate)s (BFBCs) were quantitatively synthesized through base-catalyzed fluoroalkyl carbonate esterification of diols with bis(fluoroalkyl) carbonates (BFCs). Non-isocyanate polyurethane (NIPU) synthesis was then achieved without a catalyst through polycondensation reactions of BFBCs and a series of diamines in solvent or solvent-free conditions. Compared with the previously reported synthetic methods of NIPUs, this method has the distinct advantage of synthesizing a wide variety of NIPUs including new and commercially available conventional PUs. This method allows the arbitrary synthesis of NIPUs with commonly available diols and diamines used in the industrial production of PUs by the conventional isocyanate method, or with original synthetic ones. Furthermore, when using a solvent, the polycondensation occurred below 100 °C to give a colorless PU having an average molecular weight of over 10000. Transparent films with the characteristic high elasticity of PU could be obtained from a proper combination of BFBC and diamine, one as the hard segment and the other as the soft segment. Then, a novel fluorinated PU was successfully synthesized from a fluoroalkylene BFBC and a diamine. The present new reaction will be a practically available production method of functional NIPUs.
A comparative analysis of interobserver reliability and intraobserver reproducibility of the Oswestry-Bristol Classification and the Dejour Classification for trochlear dysplasia of the knee
Authors: Roy Kunal D. , Joshi Pushkar , Ali Ibrahim , Shenoy Pritom M. , Malek Ibrahim , Barlow David , Syed Asad , Joshi Yogesh 
Published: July 2023

AimsClassifying trochlear dysplasia (TD) is useful to determine the treatment options for patients suffering from patellofemoral instability (PFI). There is no consensus on which classification system is more reliable and reproducible for the purpose of guiding clinicians’ management of PFI. There are also concerns about the validity of the Dejour Classification (DJC), which is the most widely used classification for TD, having only a fair reliability score. The Oswestry-Bristol Classification (OBC) is a recently proposed system of classification of TD, and the authors report a fair-to-good interobserver agreement and good-to-excellent intraobserver agreement in the assessment of TD. The aim of this study was to compare the reliability and reproducibility of these two classifications.MethodsIn all, six assessors (four consultants and two registrars) independently evaluated 100 axial MRIs of the patellofemoral joint (PFJ) for TD and classified them according to OBC and DJC. These assessments were again repeated by all raters after four weeks. The inter- and intraobserver reliability scores were calculated using Cohen’s kappa and Cronbach’s α.ResultsBoth classifications showed good to excellent interobserver reliability with high α scores. The OBC classification showed a substantial intraobserver agreement (mean kappa 0.628; p < 0.005) whereas the DJC showed a moderate agreement (mean kappa 0.572; p < 0.005). There was no significant difference in the kappa values when comparing the assessments by consultants with those by registrars, in either classification system.ConclusionThis large study from a non-founding institute shows both classification systems to be reliable for classifying TD based on axial MRIs of the PFJ, with the simple-to-use OBC having a higher intraobserver reliability score than that of the DJC.Cite this article: Bone Jt Open 2023;4(7):532–538.
Absorption and reduced scattering coefficient estimation in pigmented human skin tissue by experimental colorimetric fitting
Authors: Cruz Junior Luismar B. , Girasol Carlos E. , Coltro Pedro S. , Guirro Rinaldo R. J. , Bachmann Luciano 
Published: July 2023

This study aims to estimate the optical properties, absorption (μ
a
), and reduced scattering (μ
s
′) coefficients of ex vivo human skin through the individual typology angle (ITA) by only using the skin color parameters. Human skin samples were grouped according to their ITA value and measured using a colorimeter for validation. An integrating sphere and the inverse adding-doubling algorithm were applied to compute the samples μ
a
and μ
s
′. The μ
a
increases as the ITA decreases. An axis swap was performed to generate the μ
a
versus the ITA for all wavelengths between 500 nm and 800 nm with a spectral resolution of 10 nm. Linearization was performed and a correlation was found. An equation to fit μ
a
based solely on the ITA values was estimated. The μ
s
′ does not change with ITA, but it could be fit with an inverse power law as a function of the wavelength. Both equations have a coefficient of determination (R2) higher than 0.93, indicating a good agreement with our model. An experimental model to estimate the absorption and reduced scattering coefficients of ex vivo human skin through ITA was found. The model has high agreement with the experimental data, with an R2 between 0.932 and 0.997, and these findings may be relevant for photobiomodulation and light treatment applications to estimate the effect of the melanin on the therapy.
Using Readable English leads to reading gains for rural elementary students: An experimental study
Authors: Coggins Joanne Veatch 
Published: July 2023

Objectives
This study measured whether and to what degree Readable English effectively improves reading fluency and comprehension skills of adolescent learners.

Methods
This experimental study (N = 855) measured the efficacy of two different multiple component reading programs for students in grades three, four, and five. Students were pre-and post-tested using EasyCBM Grade Level Reading Benchmarks. Students scoring at/below the 30th percentile on either benchmark were also assessed with the WRMT-3 Passage Reading Comprehension and Oral Reading Fluency measures. Students received 45–60 instructional hours in either Readable English or Amplify CKLA during their regular ELA class.

Results
Students who received Readable English instruction significantly outperformed students in the typical practice condition on all measures of reading fluency and comprehension. The intervention condition’s EasyCBM benchmark reading rate (m = 29.6 WCPM), reading accuracy (m = 3.1%), and comprehension (m = 1.9) surpassed the control group’s reading rate (m = 17.4 WCPM), accuracy (m = 0.7%), and comprehension (m = 0.7) WRMT-3 ORF showed students in the Readable English intervention condition (m = 13.4 growth scale values [GSV] and m = 1.0 grade equivalency) outscored students in the control condition (m = 7.8 GSV and m = 0.5 grade equivalency). WRMT-3 Passage Comprehension showed Readable English students (m = 11.0 GSV and m = 0.9 grade equivalency) outgrew control condition students (m = 4.4 GSV and m = 0.3 grade equivalency).

Conclusions
In a school year fraught with pandemic instructional interruptions and learning loss, students in grades 3–5 who received Readable English instruction closed reading gaps. The meaningful gains in reading rate and accuracy experienced by students in the intervention group will give exponential word reading volume dividends to students able to read text faster and more accurately going forward, helping them become more skilled readers.
Media Governance: A Cosmopolitan Critique, Sarah Anne Ganter and Hanan Badr (eds) (2022)
Authors: Birkinbine Benjamin J. 
Published: July 2023

Review of: Media Governance: A Cosmopolitan Critique, Sarah Anne Ganter and Hanan Badr (eds) (2022)
Cham: Springer International Publishing, 318 pp.,
ISBN 978-3-03105-019-0, h/bk, EUR 129.99