bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genetically Engineered Brain Organoids Recapitulate Spatial and Developmental States of Glioblastoma Progression
Authors: Ishahak Matthew , Han Rowland H. , Annamalai Devi , Woodiwiss Timothy , McCornack Colin , Cleary Ryan T. , DeSouza Patrick A. , Qu Xuan , Dahiya Sonika , Kim Albert H. , Millman Jeffrey R. 
Published: January 2025

AbstractGlioblastoma (GBM) is an aggressive form of brain cancer that is highly resistant to therapy due to significant intra‐tumoral heterogeneity. The lack of robust in vitro models to study early tumor progression has hindered the development of effective therapies. Here, this study develops engineered GBM organoids (eGBOs) harboring GBM subtype‐specific oncogenic mutations to investigate the underlying transcriptional regulation of tumor progression. Single‐cell and spatial transcriptomic analyses revealed that these mutations disrupt normal neurodevelopment gene regulatory networks resulting in changes in cellular composition and spatial organization. Upon xenotransplantation into immunodeficient mice, eGBOs form tumors that recapitulate the transcriptional and spatial landscape of human GBM samples. Integrative single‐cell trajectory analysis of both eGBO‐derived tumor cells and patient GBM samples reveal the dynamic gene expression changes in developmental cell states underlying tumor progression. This analysis of eGBOs provides an important validation of engineered cancer organoid models and demonstrates their utility as a model of GBM tumorigenesis for future preclinical development of therapeutics.
The Gut Microbiota‐Xanthurenic Acid‐Aromatic Hydrocarbon Receptor Axis Mediates the Anticolitic Effects of Trilobatin
Authors: Wu Xiaoyu , Wei Jiajia , Ran Wang , Liu Dongjing , Yi Yang , Gong Miaoxian , Liu Xin , Gong Qihai , Li Haibo , Gao Jianmei 
Published: January 2025

AbstractCurrent treatments for ulcerative colitis (UC) remain limited, highlighting the need for novel therapeutic strategies. Trilobatin (TLB), a naturally derived food additive, exhibits potential anti‐inflammatory properties. In this study, a dextran sulfate sodium (DSS)‐induced animal model is used to investigate the effects of TLB on UC. It is found TLB significantly alleviates DSS‐induced UC in mice, as evidenced by a reduction in the disease activity index, an increase in colon length, improvement in histopathological lesions. Furthermore, TLB treatment results in a decrease in proinflammatory cytokines and an increase in anti‐inflammatory cytokines. TLB mitigates UC by modulating the intestinal microbiota, particularly Akkermansia, which enhances tryptophan metabolism and upregulates the production of xanthurenic acid (XANA). To confirm the role of TLB‐induced microbiota changes, experiments are performed with pseudogerm‐free mice and fecal transplantation. It is also identified XANA as a key metabolite that mediates TLB's protective effects. Both TLB and XANA markedly activate the aromatic hydrocarbon receptor (AhR). Administration of an AhR antagonist abrogates their protective effects, thereby confirming the involvement of AhR in the underlying mechanism. In conclusion, the study reveals a novel mechanism through which TLB alleviates UC by correcting microbiota imbalances, regulating tryptophan metabolism, enhancing XANA production, and activating AhR.
Manipulating Fano Coupling in an Opto‐Thermoelectric Field
Authors: Lin Linhan , Lepeshov Sergey , Krasnok Alex , Huang Yu , Jiang Taizhi , Peng Xiaolei , Korgel Brian A. , Alù Andrea , Zheng Yuebing 
Published: January 2025

AbstractFano resonances in photonics arise from the coupling and interference between two resonant modes in structures with broken symmetry. They feature an uneven and narrow and tunable lineshape and are ideally suited for optical spectroscopy. Many Fano resonance structures have been suggested in nanophotonics over the last ten years, but reconfigurability and tailored design remain challenging. Herein, an all‐optical “pick‐and‐place” approach aimed at assembling Fano metamolecules of various geometries and compositions in a reconfigurable manner is proposed. Their coupling behavior by in situ dark‐field scattering spectroscopy is studied. Driven by a light‐directed opto‐thermoelectric field, silicon nanoparticles with high‐quality‐factor Mie resonances (discrete states) and low‐loss BaTiO3 nanoparticles (continuum states) are assembled into all‐dielectric heterodimers, where distinct Fano resonances are observed. The Fano parameter can be adjusted by changing the resonant frequency of the discrete states or the light polarization. Tunable coupling strength and multiple Fano resonances by altering the number of continuum states and discrete states in dielectric heterooligomers are also shown. This work offers a general design rule for Fano resonance and an all‐optical platform for controlling Fano coupling on demand.
Transfusion‐Related Acute Lung Injury: from Mechanistic Insights to Therapeutic Strategies
Authors: Fang Xiaobin , Mo Chunheng , Zheng Ling , Gao Fei , Xue Fu‐Shan , Zheng Xiaochun 
Published: January 2025

AbstractTransfusion‐related acute lung injury (TRALI) is a potentially lethal complication of blood transfusions, characterized by the rapid onset of pulmonary edema and hypoxemia within six hours post‐transfusion. As one of the primary causes of transfusion‐related mortality, TRALI carries a significant mortality rate of 6–12%. However, effective treatment strategies for TRALI are currently lacking, underscoring the urgent need for a comprehensive and in‐depth understanding of its pathogenesis. This comprehensive review provides an updated and detailed analysis of the current landscape of TRALI, including its clinical presentation, pathogenetic hypotheses, animal models, cellular mechanisms, signaling pathways, and potential therapeutic targets. By highlighting the critical roles of these pathways and therapies, this review offers valuable insights to inform the development of preventative and therapeutic strategies and to guide future research efforts aimed at addressing this life‐threatening condition.
Targeting TTK Inhibits Tumorigenesis of T‐Cell Lymphoma Through Dephosphorylating p38α and Activating AMPK/mTOR Pathway
Authors: Liu Bingyu , Lu Tiange , Ding Mengfei , Zhou Xiaoli , Jiang Yujie , Shang Juanjuan , Sun Wenyue , Hu Shunfeng , Wang Xin , Zhou Xiangxiang 
Published: January 2025

AbstractT‐cell lymphoma (TCL) is a group of non‐Hodgkin's lymphoma with high heterogeneity and unfavorable prognosis. Current standard treatments have demonstrated limited efficacy in improving the outcomes for TCL patients. Therefore, identification of novel drug targets is urgently needed to improve the prognosis of TCL patients. Through multi‐omics analysis, aberrant expression of threonine tyrosine kinase (TTK) in TCL is identified. High expression of TTK is closely associated with poor prognosis in TCL patients. Targeting TTK through gene knockdown exerts anti‐tumor effects in vitro and in vivo, including inhibiting the cell proliferation, inducing G2/M phase arrest, enhancing DNA damage and cell apoptosis. Mechanically, p38α is identified as the potential phosphorylation substrate of TTK through phosphoproteomic quantification and motif prediction. Furthermore, inhibition of TTK suppresses activation of p38α through dephosphorylating it at Thr180/Tyr182, thereby promoting the activation of AMPK/mTOR pathway. In addition, targeting TTK enhances the autophagy in TCL cells through dephosphorylating p38α. CFI‐402257, a specific inhibitor of TTK, is found to exhibit anti‐tumor effects and exerted synergistic efficacy with PI3K inhibitor, Duvelisib, in TCL. The study shows that TTK contributes to the development of TCL by regulating p38α‐mediated AMPK/mTOR pathway. CFI‐402257 is expected to be a promising strategy for TCL treatment.
HPV E6/E7‐Induced Acetylation of a Peptide Encoded by a Long Non‐Coding RNA Inhibits Ferroptosis to Promote the Malignancy of Cervical Cancer
Authors: Qi Xiaoyu , Zhou Jing , Wang Xinyue , Shen Yan , Cao Yuxun , Jiang Liangzi , Shen Miaomiao , Zhang Haoran , Wang Tianjiao , Wei Pengjun , Xu Ruoqi , Yang Yue , Ding Xiangya , Wang Cong , Jia Xuemei , Yan Qin , Li Wan , Lu Chun 
Published: January 2025

AbstractAlthough a fraction of functional peptides concealed within long non‐coding RNAs (lncRNAs) is identified, it remains unclear whether lncRNA‐encoded peptides are involved in the malignancy of cervical cancer (CC). Here, a 92‐amino acid peptide is discovered, which is named TUBORF, encoded by lncRNA TUBA3FP and highly expressed in CC tissues. TUBORF inhibits ferroptosis to promote the malignant proliferation of CC cells. Mechanistically, human papillomavirus (HPV) oncogenes E6 and E7 upregulate TUBORF through CREB‐binding protein (CBP)/E1A‐binding protein p300 (p300)‐mediated histone H3 lysine 27 acetylation (H3K27ac) of lncTUBA3FP enhancer. Furthermore, E6 and E7 elevate and recruit acetyltransferase establishment of sister chromatid cohesion N‐acetyltransferase 1 (ESCO1) to bind to and acetylate TUBORF, which facilitates the degradation of immunity‐related GTPase Q (IRGQ) via a ubiquitin‐proteasome pathway, resulting in the inhibition of ferroptosis and promotion of the malignant proliferation of CC cells. Importantly, silencing ESCO1 or TURORF amplifies anticancer effects by paclitaxel both in CC cells and in vivo. These novel findings reveal oncopeptide TUBORF and its acetyltransferase ESCO1 as important regulators of ferroptosis and tumorigenesis during cervical cancer pathogenesis and establish the scientific basis for targeting these molecules for treating CC.
Spin Magnetic Effect Activate Dual Site Intramolecular O─O Bridging for Nickel‐Iron Hydroxide Enhanced Oxygen Evolution Catalysis
Authors: Dong Haohai , Luo Lanke , Zhou Sitong , Chen Lin , Wu Xinyu , Yang Yitao , Liao Zhensheng , Fu Liao , Chen Ming , Zhu Yuxin , Su Peiyuan , Jiang Haomin , Sun Zemin , Lin Liu , Hua Qingsong 
Published: January 2025

AbstractThe oxygen evolution reaction (OER) involves the recombination of diamagnetic hydroxyl (OH) or water (H2O) into the paramagnetic triplet state of oxygen (O2). The spin conservation of oxygen intermediates plays a crucial role in OER, however, research on spin dynamics during the catalytic process remains in its early stages. Herein, β‐Ni(OH)2 and Fe‐doped β‐Ni(OH)2 (Ni5Fe1(OH)2) are utilized as model catalysts to understand the mechanism of spin magnetic effects at iron (III) sites during OER. Combined with magnetic characterization, it is founded that the introduction of Fe transforms the antiferromagnetic Ni(OH)2 into a ferromagnetic material. Testing the magnetic response of the catalyst under an external magnetic field, the OER activity of Ni5Fe1(OH)2 is significantly enhanced in comparison to Ni(OH)2. This improvement is likely due to the introduction of iron sites, which promote spin magnetic effects and enhance reaction kinetics, thereby increasing catalytic efficiency. Combining experimental and theoretical characterization, it is discovered that the iron sites accelerate the formation of heterogeneous dual‐site O─O bridging, represented as ─Ni─O─O─Fe─, thereby effectively enhancing the kinetics of the OER reaction. This study provides a magnetic perspective on the structure‐function relationship of magnetic iron‐based catalysts and has significant implications for the design of new catalysts.
Proton Exchange Membrane with Dual‐Active‐Center Surpasses the Conventional Temperature Limitations of Fuel Cells
Authors: Liao Yucong , Zhao Shengqiu , wang Rui , Zhang Junjie , Li Hao , Liu Bingxuan , Li Yao , Zhang Aojie , Tian Tian , Tang Haolin 
Published: January 2025

AbstractHigh temperature‐proton exchange membrane fuel cells (HT‐PEMFC) call for ionomers with low humidity dependence and elevated‐temperature resistance. Traditional perfluorosulfonic acid (PFSA) ionomers encounter challenges in meeting these stringent requirements. Herein, this study reports a perfluoroimide multi‐acid (PFMA) ionomer with dual active centers achieved through the incorporation of sulfonimide and phosphonic acid groups into the side chain. The fluorocarbon skeleton and multi‐acid side chain structure facilitate the segregation of hydrophilic and hydrophobic microphases, augmenting the short‐range ordering of hydrophilic nanodomains. Furthermore, the introduction of a rigid segment‐benzene ring is employed to decrease side chain flexibility and raise the glass transition temperature. Notably, the prepared membrane exhibits a conductivity of 41 mS cm−1 at 40% relative humidity, showcasing a 1.8 times improvement over that of PFSA. Additionally, the power output of the H2‐air fuel cell based on this membrane reaches 1.5 W cm−2 at 105 °C, marking a substantial 2.3 times enhancement compared to the PFSA. This work demonstrates the unique advantages of perfluorinated ionomers with multiple protogenic groups in the development of high‐performance high‐temperature electrolyte materials.
Photocatalytic Conversion of Methane to Ethane and Propane Using Cobalt‐Cluster‐Activated GaN Nanowires
Authors: Ye Zhengwei , Long Zhuoran , Zhang Bingxing , Navid Ishtiaque Ahmed , Menzel Jan Paul , Shen Yifan , Mondal Shubham , Guo Facheng , Norris Theodore B. , Batista Victor S. , Mi Zetian 
Published: January 2025

AbstractThe photocatalytic nonoxidative coupling of methane (PNOCM) offers a promising route to synthesize valuable C2+ hydrocarbons while minimizing side reactions. Oxide‐based photocatalysts have been predominant in this field, but suffering from limited conversion rates, selectivity, and durability due to poor C−C coupling as well as overoxidation of CH4 by lattice oxygen. Here, we introduce an advancement in PNOCM for methane conversion into ethane and propane using GaN, one of the most produced semiconductors, together with trace amounts of metallic cobalt clusters (0.1 wt %). The photocatalytic system exhibits outstanding stability, maintaining performance over 110 hours, achieving conversion rates of approximately 192.3 mmol g−1 h−1 for ethane and ~17.9 mmol g−1 h−1 for propane, with virtually no coke byproducts detected, representing the highest activity and stability ever reported to our knowledge. This high activity is attributed to the critical methane activation and C−C coupling on Co cluster, which can be greatly accelerated via the ultrafast photogenerated charge transfer from p‐GaN to Co cluster. Additionally, the GaN support further synergistically enhances methane activation by in situ generating N−H and O−H species under reaction, as well as provides a vital anti‐overoxidation effect to CH4 for high selectivity and stability.
Optimizing Feeding and Pupation Bioassays to Assess the Effects of Insecticidal and Repellent Treatments on Aethina tumida Larval Development and Pupation Success
Authors: Roth Morgan A. , Gross Aaron D. 
Published: January 2025

ABSTRACTEuropean honey bee (Apis mellifera) colonies are an ideal host to the invasive beetle Aethina tumida, providing a nutrient rich environment that is protected from the elements and facilitates beetle reproduction. Although various management techniques and chemical treatments for A. tumida have been developed, understanding the efficacy of these treatments and techniques is limited. Throughout this study, several methods for impairing A. tumida development and delivering insecticidal, repellent, or antifungal treatments were examined. A series of A. tumida larval feeding bioassays developed and optimized feeding gel pellet for delivery of insecticidal treatments, revealing that A. tumida larvae are sensitive to the two common in‐hive varroa mite (Varroa destructor) treatments: coumaphos (EC50 = 25.6 ppm) and tau‐fluvalinate (EC50 = 21.2 ppm). Feeding bioassays also demonstrated that A. tumida were more sensitive to the pyrethroid compounds permethrin (EC50 = 3.37 ppm), deltamethrin (EC50 = 2.69 ppm), and bifenthrin (EC50 = 0.365 ppm), which have been previously used to control this beetle. Feeding bioassays also revealed that the antifungal drug Amphotericin B was palatable to A. tumida larvae via feeding, but was also injected into A. tumida larvae and adults. Two types of pupation bioassays were also developed to test the effects of several insecticidal and repellent treatments on pupation burrowing and pupation success. Overall, this work details specific toxicity information regarding common insecticidal treatments found in the apiary setting study and provides groundwork and methods for testing insecticidal compounds on A. tumida larvae in in the future.
Unlocking Dividend Potential Through the Power of Sustainable Disclosures: Moderating Role of Financial Constraints
Authors: Malik Neha , Kashiramka Smita 
Published: January 2025

ABSTRACTBased on signalling and stakeholder theory, this research empirically explores the relationship between sustainability disclosure by firms and their dividend payouts in emerging economies. Various measures such as likelihood of paying dividends, stability of dividend disbursed, dividend payout ratio and dividend yield are employed to test the research hypotheses. Panel dataset covering firms from 16 emerging economies spanning from 2015 to 2022 is analysed using Logit model, Tobit model and Random Effect model. The findings demonstrate a favourable relationship between ESG disclosure scores and dividend payouts of firms. Higher ESG scores are associated with a greater likelihood of paying dividends, higher dividend payments, ensuring the stability of these payments and delivering higher implied shareholder returns through dividend yield. These effects are more pronounced for firms under greater financial constraints. Importantly, these results remain robust across various sensitivity analyses involving alternative measures, estimation methods and instrumental variable regression. These findings hold implications for investors, managers and policymakers, offering valuable insights for companies to structure their sustainability initiatives. By examining and integrating corporate finance and sustainability, this study introduces ESG scores as a novel nonfinancial driver of corporate payouts, thus marking the pioneering contribution to the ESG‐dividend literature in emerging nations.
Implementing Extended Producer Responsibility in Organizations: A Bibliometric Review
Authors: Kripalani Mukesh , Gajjar Hasmukh , Kumar Bipul 
Published: January 2025

ABSTRACTExtended producer responsibility (EPR) is an obligation for manufacturers to ensure environmentally sound management of their goods, even after they have been sold to consumers. Governments frame EPR rules for better waste management, and violating these rules may lead to penalties. This study aims to understand the intellectual structure of EPR and to define a framework of EPR enablers, which can help organizations devise strategies to manage their obligations effectively. The study conducts a bibliometric review of 749 journal articles published between 2012 and 2023 using the bibliometrix and the VOSViewer packages. The findings identify five knowledge clusters: EPR process and drivers; policy and legislation; consumer behavior and EPR; EPR and business models; and use of technology and science. Semi‐structured interviews with industry practitioners help discover prioritization among these clusters. Researchers and organizations can use these findings to take action and understand EPR from a more holistic perspective.
Sustainable HRM Impact on Employees' Behaviors Through Workplace Spirituality
Authors: Gomes Gabriela Pedro , Coelho Arnaldo , Ribeiro Neuza 
Published: January 2025

ABSTRACTThis study explores the link between sustainable HRM, workplace spirituality (WS), and employee behaviors, namely, organizational citizenship behavior for the environment (OCBE) and proactive behavior (PB). Utilizing a double source data collection method, this research incorporates the perspectives of both managers and employees. A sample of 314 dyads was analyzed. Structural equation modeling was employed to test the proposed hypotheses. It was found that sustainable HRM positively influences WS and OCBE. However, no significant direct impact was identified on PB. WS acts as a full mediator in this relationship. These results also show a strong association between WS and OCBE. This study underscores the crucial role of sustainable HRM in fostering WS and promoting OCBE while raising important questions about PB in a sustainability context. These insights contribute to understanding how organizations can use sustainable HRM to enhance employee responsible behaviors and create a workplace that supports employees' spiritual well‐being.
Designed Synthesis of Amino‐Azo‐Quinoline and Their Nickel(II) Complexes: Molecular Structure, Electrochemistry and an Insight Into Their In Vitro Anti‐Cancer Activities
Authors: Naskar Srijita , Sarkar Koushik , Halder Supriyo , Chatterjee Bidisha , Chakraborty Debjeet , Laha Arka , Sharma Rahul , Mitra Arup Kumar , Pramanik Kausikisankar , Ganguly Sanjib 
Published: January 2025

ABSTRACTAmino‐quinolines are potential candidates that may provide some insight into the current chemotherapeutic research due to their demonstrated anti‐cancer activity. This led us to synthesize and explore a new amino‐azo‐quinoline ligand H2L 1 and its square planar nickel(II) complexes [Ni(HL) (OAc)], 2 and [Ni(HL)Cl], 3 and the structures were determined by Single Crystal X‐Ray Diffraction. Theoretical investigation of redox orbitals of the complexes discloses that the reduction process is due to ligand reduction whereas both metal and ligand are contributing towards oxidation. The anti‐cancer properties of the ligand and one of the nickel(II) complexes have been assessed by 3‐[4,5‐dimethylthiazol‐2‐yl]‐2,5‐diphenyltetrazolium bromide assay, cell migration along with the generation of reactive oxygen species using human epithelial cancer cell line cells. The ligand 1 and complex 3 have been found to show effective anti‐cancer activity and for the latter, it is more promising. This may be ascribed to the rigid and robust nature of square planar complex 3, which supports stronger binding with DNA than that of free ligands, possibly due to the flexible nature of the latter. This result has also been validated by molecular docking using nine conformers of the ligand and complex 3 via interaction with B‐DNA (PDB ID: 1BNA) where the binding affinity with the complex has been found to be stronger.
Design and Evaluation of Novel Selective BET BD2 Inhibitors by Combining QSAR, Molecular Docking and Molecular Dynamics Simulation Techniques
Authors: Tong Jian‐Bo , Sun Yue , Chang Ze‐Lei , Zhang Ya‐Kun , Xing Xiao‐Yu , Yan Jing , Li Jia‐Le 
Published: January 2025

ABSTRACTBromodomain and extra terminal domain (BET) proteins play important roles in biological processes, such as cell proliferation, differentiation, and signaling, and are involved in the occurrence and development of many diseases, including cancer and inflammatory diseases. Selective inhibitors targeting the first bromodomain (BD1) or the second bromodomain (BD2) have triggered a new wave of research to produce more specific and safer drugs. In this study, 37 novel selective BET BD2 inhibitors with anti‐inflammatory activity are selected to construct robust Topomer CoMFA (q2 = 0.689, r2 = 0.916) and HQSAR (q2 = 0.805, r2 = 0.906) models, and both models have good external prediction ability. On the basis of quantitative structure–activity relationship (QSAR) results and ZINC15 database screening, 23 new compounds with ideal inhibitory activity are successfully designed. The stability and feasibility of binding the newly designed compounds to the target protein are further verified by molecular docking and molecular dynamics simulation validation. In conclusion, this work not only provides a reliable QSAR model as a screening tool for future anti‐inflammatory drug development but also provides a theoretical basis for the design and modification of subsequent selective BET BD2 inhibitors.