bluuebunny/crossref_metadata_2025_split huggingface dataset:
Basic helix–loop–helix ARNT like 1 regulates the function of immune cells and participates in the development of immune-related diseases
Authors: Shao Fanglin , Wang Zhipeng , Ye Luxia , Wu Ruicheng , Wang Jie , Yu Qing-Xin , Wusiman Dilinaer , Tuo Zhouting , Yoo Koo Han , Shu Ziyu , Wei Wuran , Li Dengxiong , Cho William C , Liu Zhihong , Feng Dechao 
Published: January 2025

Abstract
The circadian clock is an internal timekeeper system that regulates biological processes through a central circadian clock and peripheral clocks controlling various genes. Basic helix–loop–helix ARNT-like 1 (BMAL1), also known as aryl hydrocarbon receptor nuclear translocator-like protein 1 (ARNTL1), is a key component of the circadian clock. The deletion of BMAL1 alone can abolish the circadian rhythms of the human body. BMAL1 plays a critical role in immune cell function. Dysregulation of BMAL1 is linked to immune-related diseases such as autoimmune diseases, infectious diseases, and cancer, and vice versa. This review highlights the significant role of BMAL1 in governing immune cells, including their development, differentiation, migration, homing, metabolism, and effector functions. This study also explores how dysregulation of BMAL1 can have far-reaching implications and potentially contribute to the onset of immune-related diseases such as autoimmune diseases, infectious diseases, cancer, sepsis, and trauma. Furthermore, this review discusses treatments for immune-related diseases that target BMAL1 disorders. Understanding the impact of BMAL1 on immune function can provide insights into the pathogenesis of immune-related diseases and help in the development of more effective treatment strategies. Targeting BMAL1 has been demonstrated to achieve good efficacy in immune-related diseases, indicating its promising potential as a targetable therapeutic target in these diseases.
Hacia un análisis comparativo de la política autoritaria de derechas: Argentina, India y Estados Unidos
Authors: Bauer A J , Roy Srirupa , Gago Verónica 
Published: January 2025

Resumen
Los partidos e ideologías de extrema derecha han adquirido mayor protagonismo en varios países a lo largo de la última década, en coincidencia con la amplia difusión internacional de las redes sociales. Esta entrevista, en la que participan especialistas situados en los contextos de Argentina, India y Estados Unidos, cuestiona los planteamientos deterministas de los medios de comunicación. Haciendo hincapié en la contingencia histórica y la especificidad política a nivel de país, plantea un enfoque comparativo para estudiar el autoritarismo de extrema derecha en distintos contextos nacionales, en contra del determinismo y a favor de la resistencia internacional.
Reported Neurologic Manifestations Among Persons With Syphilis by Stage of Infection—12 States, 2019–2022
Authors: Wondmeneh Sarah B , McDonald Robert , Quilter Laura A S , Workowski Kimberly A , Torrone Elizabeth A , Jackson David A 
Published: January 2025

Abstract
National case-based surveillance data show that reported neurologic manifestations of syphilis increased during 2019–2022 among persons with early and late-stage syphilis. Neurologic manifestations occurred across demographic groups and among those with and without human immunodeficiency virus (HIV), highlighting the importance of evaluating for neurologic signs and symptoms in all persons with syphilis.
Insurance versus digital harm: a content analysis of home and cyber insurance policies in the USA and UK
Authors: Jain Rachiyta , Hrle Temima , Woods Daniel W 
Published: January 2025

Abstract
The adoption of digital technology creates the potential for new harms. Given that risk prevention solutions are imperfect, individuals may wish to transfer digital risk to an insurer. It is unclear whether existing insurance policies cover these harms, or whether specialized consumer cyber insurance products are available. We address this research gap by conducting a content analysis of 50 insurance policies, 32 in the USA and 18 in the UK. Our analysis of 26 home insurance policies reveals that insurers typically exclude digital perils (losses caused by computer viruses, hacking, or cyber attacks), but include coverage for digital assets (devices and downloaded data) impacted by conventional perils. A minority of home insurance policies affirmatively cover digital perils such as identity theft and social media defamation. Our analysis of 24 consumer cyber insurance products identifies 6 core perils that are generally covered: cyber attack, data breach, ransomware, online fraud, cyberbullying, and identity theft. Finally, pricing information from 21 policies reveals that specialist cyber policies typically cost between $20 and $150. One insurer’s actuarial calculations suggest that the expected losses range from $2 (online fraud) to $9 (computer attack). These findings can help users form strategies to manage digital risk.
Characterizing cardiac adipose tissue in post-acute myocardial infarction patients via CT imaging: a comparative cross-sectional study
Authors: Wang Xiaomeng , Leng Shuang , Adamson Philip D , Greer Charlotte E , Huang Weimin , Lee Hwee Kuan , Loong Yan Ting , Raffiee Nur Amirah Syahindah , Sia Ching Hui , Tan Swee Yaw , Tan Sock Hwee , Teo Lynette Li San , Wong Sung Lung , Yang Xiaoxun , Yew Min Sen , Yong Thon Hon , Zhong Liang , Shaw Leslee J , Chan Mark Yan Yee , Hausenloy Derek J , Baskaran Lohendran 
Published: January 2025

Abstract

Aims
To identify differences in CT-derived perivascular adipose tissue (PVAT) and epicardial adipose tissue (EAT) characteristics that may indicate inflammatory status differences between post-treatment acute myocardial infarction (AMI) and stable coronary artery disease (CAD) patients.

Methods and results
A cohort of 205 post-AMI patients (age 59.8 ± 9.2, 92.2% male) was propensity-matched with 205 stable CAD patients (age 60.5 ± 10.0, 90.2% male). Coronary CT angiography and non-contrast CT scans were performed to assess PVAT mean attenuation across major coronary segments and EAT mean attenuation and volumes, respectively. For post-AMI patients, CT scans were conducted 28.6 ± 13.8 days after the AMI incidence. Post-AMI patients showed higher non-culprit PVAT and EAT mean attenuation than stable CAD patients (8.01 HU, 95% CI 5.90–10.11 HU, P &lt; 0.001, 2.48 HU, 95% CI 0.83–4.13 HU, P = 0.003, respectively). The EAT volume percentage at higher attenuation levels was higher in post-AMI patients compared with stable CAD (33.93 cm3, 95% CI 16.86–51.00 cm3, P &lt; 0.001), with the difference maximized at the −70 HU threshold (4.75%, 95% CI 3.64%–5.87%, P &lt; 0.001). PVAT mean attenuation positively correlated with EAT mean attenuations and the percentage of EAT volume &gt; −70 HU (P &lt; 0.001 for both).

Conclusion
Post-AMI patients showed higher PVAT and EAT attenuation than stable CAD patients, potentially indicating AMI-associated inflammatory cardiac adipose tissue changes. A total of −70 HU can act as a potential cut-off for inflamed EAT. These findings highlight the potential of using CT-derived adipose tissue characteristics to assess inflammation and guide post-AMI management strategies.
Acute heart failure due to fulminant eosinophilic myocarditis with mononeuritis: eosinophilic granulomatosis with polyangiitis requiring cardiac multimodality imaging and systemic evaluation: a case report
Authors: Noiri Jun-ichi , Matsuzoe Hiroki , Nishio Ryo , Fujiki Youhei , Otani Kenichiro , Inaba Mayumi , Takaishi Hiroshi , Tanaka Hidekazu 
Published: January 2025

Abstract

Background
Eosinophilic granulomatosis with polyangiitis (EGPA) is a systemic vasculitis that affects small-to-medium vessels of various organs and can lead to eosinophilic myocarditis, a rare but life-threatening condition. The diagnosis of EGPA is challenging due to overlapping features with other forms of vasculitis. Additionally, various clinical presentations of EGPA make its management complicated.

Case summary
A 55-year-old man with a history of asthma presented with worsening chest pain. Peripheral hyper-eosinophilia, elevated troponin level, refractory pulseless ventricular tachycardia, and severe cardiac dysfunction suggested fulminant eosinophilic myocarditis. A multidisciplinary team comprising rheumatology, respirology, haematology, pathology, and cardiology specialists discussed the underlying cause of eosinophilia and diagnosed EGPA with the pathological findings of endomyocardial biopsy (EMB). Immunosuppressive therapy and optimal medical therapy for acute heart failure resulted in remission of myocarditis, as confirmed by follow-up echocardiography, cardiac magnetic resonance imaging, and EMB. Despite a good clinical course, mononeuritis rapidly worsened just before his discharge, requiring additional therapy. During the 2-year outpatient follow-up, the cardiac function remains well, and mononeuritis also improved.

Discussion
The multidisciplinary approach facilitated prompt and accurate diagnosis and treatment, despite the disease’s diverse presentation, ultimately saving the patient’s life. This case highlights the importance of systemic evaluations in patients with EGPA, potentially affecting multiple organs, for monitoring disease status and guiding its treatment. This case report also emphasizes that close follow-up and careful monitoring with cardiac multimodality imaging are important to ensure optimal management of heart failure caused by EGPA myocarditis.
Micro-environmental changes indicate potential for subclinical intestinal tissue damage in early-age-onset colorectal cancer patients
Authors: Kraus Sean G , Johnson Katherine A , Emmerich Philip B , Clipson Linda , Pasch Cheri A , Zhang Wei , Matkowskyj Kristina A , Deming Dustin A 
Published: January 2025

Abstract

Background
While improved screening rates have contributed to an overall decrease in the incidence of colorectal cancer (CRC), the incidence of early-age-onset CRC (EAO CRC; age &lt;50 years) has increased. Here, we characterize the genetic alterations and tumor microenvironment (TME) for EAO and later-age-onset (LAO) CRCs to identify relevant biological differences that might point to etiologic factors.

Methods
A cohort of EAO (n = 60) and LAO (n = 93) CRC patients were evaluated for mutations by using targeted DNA sequencing and for TME differences by using immunohistochemistry and immunofluorescence. The Cancer Genome Atlas (TCGA) PanCancer Atlas colorectal adenocarcinoma cohort was evaluated for transcriptional changes between EAO (n = 82) and LAO (n = 510) patients.

Results
KRAS and BRAF mutations were less frequent in EAO CRCs. Gene-set enrichment analysis of TCGA data revealed the downregulation of immune-related pathways in EAO CRCs. Both age cohorts had similar numbers of CD8+ tumor-infiltrating lymphocytes (TILs), although LAO patients had more CD4+ TILs and Th1-polarized CD4s. While significant associations between immune subsets and versican (VCAN), versikine, and alpha-smooth muscle actin (αSMA) were found, none of these trends differed between age cohorts. EAO patients trended towards greater VCAN accumulation in adjacent normal tissue, lower rates of VCAN proteolysis, and decreased αSMA accumulation vs LAO patients.

Conclusions
Overall, established EAO cancers are similar to LAO cancers in mutational profile and key TME features. High VCAN and αSMA expression in adjacent normal colon indicates a presence of factors that are associated with increased intestinal subclinical inflammation. Future mechanistic studies will be conducted to better understand the importance of these findings and related processes should be prioritized as potential etiologic factors for EAO tumorigenesis.
Direction finding in an active source experiment in Fürstenfeldbruck, Germany using 6 DoF measurements
Authors: Izgi Gizem , Eibl Eva P S , Krueger Frank , Bernauer Felix 
Published: January 2025

SUMMARY
The seismic wavefield is fully described by translation, rotation and strain. Until recently, the seismological community has not been able to measure rotation directly with portable sensors with satisfactory resolution. Portable blueSeis-3A (Exail) sensors allow measuring three components of rotational motions. Colocated with conventional seismometers, one can locally observe six degrees of freedom (6 DoF) of ground motion. To test the performance of the rotational sensors, an active source experiment was carried out in Fürstenfeldbruck, Germany, in 2019 November. Five explosions with different yields and distances from our sensors, were fired. In a first stage, eight rotational sensors were deployed inside a bunker next to a seismometer. In a second stage, the rotational sensors were installed in two clusters of four sensors each. We compare the backazimuths derived using two different methods: (i) a method using horizontal rotational components and (ii) a standard polarization analysis using only 3C translational data. Backazimuths calculated using rotational data for five explosions have an average $10.2^\circ$ deviation from the theoretical backazimuths. Estimates using 3C translational data for the first stage of the experiment have a $1.8^\circ$ deviation from the theoretical backazimuth. For the second stage, we found a $29.4^\circ$ deviation using the seismometer from stage 1. We conclude that within our distance range from 50 to 1070 m, all rotational sensors provide reliably backazimuths of explosive sources when using only horizontal rotational components. For future applications of rotational sensors in other environments, this is promising as backazimuths can be derived reliably.
Functional variants in the cystic fibrosis transmembrane conductance regulator (CFTR) gene are associated with increased risk of colorectal cancer
Authors: Prizment Anna , Standafer Abby , Qu Conghui , Beutel Kathleen M , Wang Shuo , Huang Wen-Yi , Lindblom Annika , Pearlman Rachel , Van Guelpen Bethany , Wolk Alicja , Buchanan Daniel D , Grant Robert C , Schmit Stephanie L , Platz Elizabeth A , Joshu Corinne E , Couper David J , Peters Ulrike , Starr Timothy K , Scott Patricia , Pankratz Nathan 
Published: January 2025

Abstract

Background
Individuals with cystic fibrosis (CF; a recessive disorder) have an increased risk of colorectal cancer (CRC). Evidence suggests individuals with a single CFTR variant may also have increased CRC risk.

Methods
Using population-based studies (GECCO, CORECT, CCFR, and ARIC; 53 785 CRC cases and 58 010 controls), we tested for an association between the most common CFTR variant (Phe508del) and CRC risk. For replication, we used whole exome sequencing data from UK Biobank (UKB; 5126 cases and 20 504 controls matched 4:1 based on genetic distance, age, and sex), and extended our analyses to all other heterozygous CFTR variants annotated as CF-causing.

Results
In our meta-analysis of GECCO-CORECT-CCFR-ARIC, the odds ratio (OR) for CRC risk associated with Phe508del was 1.11 (P = 0.010). In our UKB replication, the OR for CRC risk associated with Phe508del was 1.28 (P = 0.002). The sequencing data from UKB also revealed an association between the presence of any other single CF-causing variant (excluding Phe508del) and CRC risk (OR = 1.33; P = 0.030). When stratifying CFTR variants by functional class, class I variants (no protein produced) had a stronger association (OR = 1.77; p = 0.002), while class II variants (misfolding and retention of the protein in the endoplasmic reticulum) other than Phe508del (OR = 1.75; p = 0.107) had similar effect size as Phe508del, and variants in classes III-VI had non-significant ORs less than 1.0 and/or were not present in cases.

Conclusions
CF-causing heterozygous variants, especially class I variants, are associated with a modest but statistically significant increased CRC risk. More research is needed to explain the biology underlying these associations.
Bacillus subtilis MZ-01 alleviates diarrhea caused by ETEC K88 by reducing inflammation and promoting intestinal health
Authors: Qin Jianwei , Liu Yang , Cao Mingming , Zhang Yue , Bai Guangdong , Shi Baoming 
Published: January 2025

Abstract

Aims
The purpose of this study was to investigate the effects of Bacillus subtilis supplementation on the health of weaned piglets and whether B. subtilis supplementation can reduce the damage of piglets induced by ETEC K88.

Methods and results
The experiment was designed with a 2 × 2 factorial arrangement, comprising the control group, B. subtilis (PRO) group, Escherichia coli K88 (ETEC) group, and B. subtilis + ETEC (PRO + ETEC) group. Regardless of the presence of ETEC, the addition of PRO increased the piglets’ final body weight, average daily gain, and daily feed intake. Additionally, PRO primarily achieves a reduction in heat-stable enterotoxin (ST) levels, suppresses the expression of NF-κB, TLR4, and MyD88 mRNA in the jejunum and ileum, lowers pro-inflammatory factors in the blood and small intestine, enhances the expression of tight junction proteins in the small intestine, improves the composition of the colonic microbiota, increases colonic short-chain fatty acid contents, thereby alleviating diarrhea and mitigating bodily damage caused by ETEC K88 infection.

Conclusion
The addition of B. subtilis MZ-01 alleviated ETEC K88-induced piglet diarrhea by reducing ST levels, decreasing pro-inflammatory factors in the blood and intestine, and enhancing the intestinal barrier and tight junction proteins.
Interdisciplinary systems may restore the healthcare professional–patient relationship in electronic health systems
Authors: Cauley Michael R , Boland Jr. Richard J , Rosenbloom S Trent 
Published: January 2025

Abstract

Objective
To develop a framework that models the impact of electronic health record (EHR) systems on healthcare professionals’ well-being and their relationships with patients, using interdisciplinary insights to guide machine learning in identifying value patterns important to healthcare professionals in EHR systems.

Materials and Methods
A theoretical framework of EHR systems’ implementation was developed using interdisciplinary literature from healthcare, information systems, and management science focusing on the systems approach, clinical decision-making, and interface terminologies.

Observations
Healthcare professionals balance personal norms of narrative and data-driven communication in knowledge creation for EHRs by integrating detailed patient stories with structured data. This integration forms 2 learning loops that create tension in the healthcare professional–patient relationship, shaping how healthcare professionals apply their values in care delivery. The manifestation of this value tension in EHRs directly affects the well-being of healthcare professionals.

Discussion
Understanding the value tension learning loop between structured data and narrative forms lays the groundwork for future studies of how healthcare professionals use EHRs to deliver care, emphasizing their well-being and patient relationships through a sociotechnical lens.

Conclusion
EHR systems can improve the healthcare professional–patient relationship and healthcare professional well-being by integrating norms and values into pattern recognition of narrative and data communication forms.
Adaptation and validation of the French version of the Hypoparathyroid Patient Questionnaire 28 (HPQ28) in the ComPaRe-Epi-Hypo e-cohort
Authors: Bertocchio Jean-Philippe , Soyer Jessica , Grosset Natalie , Bessonies Delphine , Nidercorn Christelle , Sido Coralie , Tran Viet-Thi , Toko-Kamga Leslie , Pane Isabelle , Hecini Akram , Siggelkow Heide , Houillier Pascal 
Published: January 2025

Abstract
Chronic hypoparathyroidism is a rare disease associated with an impaired quality of life. Recommendations suggest frequent monitoring of quality of life, but for French-speaking people, only generic scales are available despite the fact that chronic hypoparathyroidism has specific symptoms and impact. The aim of this study was to adapt and validate the French version of Hypoparathyroid Patient Questionnaire 28 (HPQ28), an already validated tool in patients living with chronic hypoparathyroidism, available in English and German. HPQ28 was translated and back-translated from English into French. Translations were harmonized with the original author. Assessment of psychometric properties of the French version of HPQ28 was performed in the ComPaRe-Epi-Hypo e-cohort, a nationwide cohort of adult patients living with chronic hypoparathyroidism in France. Internal consistency was evaluated using Cronbach’s alpha. Dimensional validity was studied using confirmatory factor analysis (CFA). Construct validity compared the answers from the French version of HPQ28 with those from the EQ-5D-5L, EQ-5D-VAS, and MYMPO2 instruments. Reliability was evaluated by the intra-class correlation coefficient (ICC) of a test–retest within a 2-wk interval. Between August 2023 and August 2024, 183 patients completed HPQ28, EQ-5D, and MYMOP2 scales. The majority (92%) of the participants were women, with a median[IQR] age of 52[44;60]. Etiology of the disease was neck surgery and genetic abnormalities in 82% and 8% of cases, respectively. Internal consistency was good (Cronbach’s alpha 0.93, 95% CI 0.91 to 0.94). CFA found a unidimensional structure of the questionnaire. Construct validity showed positive correlation with MYMOP2 (r = 0.64) and negative correlations with EQ-5D VAS (r = −0.49) and EQ-5D-5L (r = −0.64) scores, as hypothesized. Reliability was adequate, with an ICC of 0.88 (95% CI 0.84 to 0.91). In conclusion, we adapted and validated HPQ28 for French-speaking patients suffering from chronic hypoparathyroidism. It can therefore now be used for both research and clinical follow-up.
Revisiting Productivity Dynamics in Europe: A New Measure of Utilization-Adjusted TFP Growth
Authors: Comin Diego , Quintana Javier , Schmitz Tom , Trigari Antonella 
Published: January 2025

Abstract
We compute new estimates of Total Factor Productivity (TFP) growth in the five largest European economies. Our estimates account for positive profits and use firm surveys to proxy for unobserved changes in factor utilization. These novelties have a major impact: our estimated TFP growth series are substantially less volatile and less cyclical than the ones obtained with standard methods. Based on our approach, we provide annual industry-level and aggregate TFP series, as well as the first estimates of profit and utilization-adjusted quarterly TFP growth in Europe/
Place-based policies: first-mover advantage and persistence
Authors: Chen Ying , Huang Teng , Xie Xiaochen 
Published: January 2025

Abstract
Researchers have explored various place-based policies for promoting economic growth, but the long-term effects and drivers of successful policies have not been thoroughly studied. In this article, we first document significant heterogeneity in growth trends between early and late national development zones in China. Then, we develop a theoretical framework to analyze the influence of their establishment timing on the spatial equilibrium dynamics. Using new archival data and novel empirical strategies, we demonstrate that the early zones consistently have higher firm entries, innovation, and labor pooling. These results highlight the importance of agglomeration for the long-term success of place-based policies.