bluuebunny/crossref_metadata_2025_split huggingface dataset:
FORMULASI DAN UJI MUTU FISIK KRIM ANTI JERAWAT EKSTRAK BUNGA LAWANG ILLICIUM VERUM
Authors: Devin Suwandi Mifta , Monica Eva , Rollando Rollando 
Published: April 2023

Bunga lawang (Illicium verum)adalah sebuah tanaman herbal berjenis obat-obatan yang mempunyai kandungan berupa senyawa bioaktif yakni saponin, tanin, flavonoid, orthidhine E, Adriadysiolide, dan minyak atsiri. Tanaman ini dapat digunakan sebagai antibakteri yang memiliki efek samping yang rendah. Krim anti jerawat adalah sediaan yang memiliki kandungan berupa berbagai macam bahan yang dibutuhkan untuk kulit wajah yang mengalami masalah berjerawat. Penelitian yang dilakukan ini mempunyai tujuan guna mengetahui bahan ataupun formula untuk krim anti jerawat ekstrak bunga lawang (Illicium verum) dengan uji mutu fisik serta uji antibakteri pada bakteri Staphylococcus epidermidis. Penelitian yang dilakukan ini adalah sebuah penelitian yang berjenis eksperimen dengan tujuan guna mengetahui formula baru dengan bahan aktif ekstrak bunga lawang (Illicium verum) dengan gambaran kuantitatif yang menggunakan analisa data anova one way. Ada pula tahap uji yang akan dilaksanakan adalah pengujian mutu fisik dari sediaan yang tersusun dari, pengujian homogenitas, pengujian organoleptis, pengujian PH, pengujian daya lekat, pengujian daya sebar, pengujian jenis krim, pengujian ukuran partikel viskositas, dan uji antibakteri. Berdasarkan hasil penelitian yang dilakukan, bahwa formula 3 krim anti jerawat ekstrak bunga lawang (Illicium verum) mempunyai keunggulan yang lebih maksimal daripada dua bahan ataupun formula yang lainnya, hal tersebut dapat dilihat dari pengujian homogenitas, pengujian organoleptis, pengujian PH, pengujian daya lekat, pengujian tipe emulsi dari krim, dan pengujian ukuran partikel krim dan uji aktivitas antibakteri dengan kategori sedang pada bakteri Staphylococcus epidermidis dengan konsentrasi ekstrak bunga lawang (Illicium verum) 10% .
Identification and validation of a novel cuproptosis-related gene signature in multiple myeloma
Authors: Zhang Bingxin , Wang Quanqiang , Zhang Tianyu , Zheng Ziwei , Lin Zhili , Zhou Shujuan , Zheng Dong , Chen Zixing , Zheng Sisi , Zhang Yu , Lin Xuanru , Dong Rujiao , Chen Jingjing , Qian Honglan , Hu Xudong , Zhuang Yan , Zhang Qianying , Jin Zhouxiang , Jiang Songfu , Ma Yongyong 
Published: April 2023

Background: Cuproptosis is a newly identified unique copper-triggered modality of mitochondrial cell death, distinct from known death mechanisms such as necroptosis, pyroptosis, and ferroptosis. Multiple myeloma (MM) is a hematologic neoplasm characterized by the malignant proliferation of plasma cells. In the development of MM, almost all patients undergo a relatively benign course from monoclonal gammopathy of undetermined significance (MGUS) to smoldering myeloma (SMM), which further progresses to active myeloma. However, the prognostic value of cuproptosis in MM remains unknown.Method: In this study, we systematically investigated the genetic variants, expression patterns, and prognostic value of cuproptosis-related genes (CRGs) in MM. CRG scores derived from the prognostic model were used to perform the risk stratification of MM patients. We then explored their differences in clinical characteristics and immune patterns and assessed their value in prognosis prediction and treatment response. Nomograms were also developed to improve predictive accuracy and clinical applicability. Finally, we collected MM cell lines and patient samples to validate marker gene expression by quantitative real-time PCR (qRT-PCR).Results: The evolution from MGUS and SMM to MM was also accompanied by differences in the CRG expression profile. Then, a well-performing cuproptosis-related risk model was developed to predict prognosis in MM and was validated in two external cohorts. The high-risk group exhibited higher clinical risk indicators. Cox regression analyses showed that the model was an independent prognostic predictor in MM. Patients in the high-risk group had significantly lower survival rates than those in the low-risk group (p &lt; 0.001). Meanwhile, CRG scores were significantly correlated with immune infiltration, stemness index and immunotherapy sensitivity. We further revealed the close association between CRG scores and mitochondrial metabolism. Subsequently, the prediction nomogram showed good predictive power and calibration. Finally, the prognostic CRGs were further validated by qRT-PCR in vitro.Conclusion: CRGs were closely related to the immune pattern and self-renewal biology of cancer cells in MM. This prognostic model provided a new perspective for the risk stratification and treatment response prediction of MM patients.
A process-model-free method for model predictive control via a reference model-based proportional-integral-derivative controller with application to a thermal power plant
Authors: Shi Gengjin , Ma Miaomiao , Li Donghai , Ding Yanjun , Lee Kwang Y. 
Published: April 2023

Introduction: Model predictive control (MPC) is an advanced control strategy which can achieve fast reference tracking response and deal with process constraints, time delay and multivariable problems. However, thermal processes in coal-fired power plants are usually difficult to model accurately, which limits the application of MPC to thermal power plants.Methods: To solve the problem, this paper proposes a process-model-free method for MPC via a reference model (RM)-based controller, i.e., a desired dynamic equational (DDE) proportional-integral-derivative (PID) controller (DDE-PID).Results and Discussion: The DDE-PID can provide the design model and enhance the disturbance rejection ability for MPC. Simulations and results of field tests on a coal-fired unit show the superiorities of the proposed controller in reference tracking, disturbance rejection and robustness, which indicates the promising prospect of the field application of the MPC with DDE-PID, or MPC-DDE in short, to thermal power plants.
Incidence of biopsy-proven giant cell arteritis (GCA) in South Australia 2014–2020
Authors: Ninan Jem , Ruediger Carlee , Dyer Kathryn A. , Dodd Thomas , Black Rachel J. , Lyne Suellen , Shanahan Ernst M. , Proudman Susanna M. , Lester Susan , McNeil Julian , Hill Catherine L. 
Published: April 2023

ObjectiveTo determine the incidence of biopsy proven giant cell arteritis (GCA) in South Australia.MethodsPatients with biopsy-proven GCA were identified from pathology reports of temporal artery biopsies at state-based pathology laboratories, from 1 January 2014 to 31 December 2020. Incidence rates for biopsy-proven GCA were calculated using Australian Bureau of Statistics data for South Australian population sizes by age, sex, and calendar year. Seasonality was analyzed by cosinor analysis.ResultsThere were 181 cases of biopsy-proven GCA. The median age at diagnosis of GCA was 76 years (IQR 70, 81), 64% were female. The estimated population incidence for people over 50 was 5.4 (95% CI 4.7, 6.1) per 100,000-person years. The female: male incidence ratio was 1.6 (95% CI 1.2, 2.2). There was no ordinal trend in GCA incidence rates by calendar year (p = 0.29). The incidence was, on average, highest in winter, but not significantly (p = 0.35). A cosinor analysis indicated no seasonal effect (p = 0.52).ConclusionThe incidence of biopsy-proven GCA remains low in Australia. A higher incidence was noted compared to an earlier study. However, differences in ascertainment and methods of GCA diagnosis may have accounted for the change.
HIV-1 tropism in low-level viral load HIV-1 infections during HAART in Guangdong, China
Authors: Zhang Chuyu , Lan Yun , Li Linghua , He Ruiying , Meng Yu , Li Jian , Chen Weilie 
Published: April 2023

BackgroundSince only a few studies have been conducted on the factors associated with different HIV-1 tropisms in low-level viral load HIV-1 infections in China, we investigated the sequences of HIV-1 V3 loop in prevalent HIV-1 subtypes and factors related to HIV-1 tropism and immune recovery in HIV-1 infections after 6 months of highly active antiretroviral therapy (HAART) in Guangdong, China.MethodsPlasma samples with HIV-1 RNA of 400–999 copies/mL were collected. We analyzed the amino acid sequence of the V3 loop by in silico prediction algorithms. Mann–Whitney and Chi-square tests were used for statistical comparison. Furthermore, logistic regression and multiple linear regression were used, respectively, for factors associated with 351 HIV-1 tropism and immune recovery of 67 cases with continued CD4+ T cell count during HAART.ResultsThere was a lower percentage of HIV-1 R5-tropic virus in CRF01_AE (66.3%) (p &lt; 0.0001) and CRF55_01B (52.6%) (p &lt; 0.0001) compared with both CRF07_BC (96.1%) and CRF08_BC (97.4%), respectively. Compared with the R5-tropic virus, higher proportions of IIe8/Val8, Arg11/Lys11, and Arg18/His18/Lys18 were observed in the X4-tropic virus of CRF01_AE and CRF07_BC (p &lt; 0.0001). The baseline CD4+ T cell count (p &lt; 0.0001) and baseline CD4+ T/CD8+ T ratio (p = 0.0006) of all R5-tropic infections were higher than those in the X4-tropic infection. The baseline CD4+ T cell count (odds ratio [OR] 0.9963, p = 0.0097), CRF07_BC (OR 0.1283, p = 0.0002), and CRF08_BC (OR 0.1124, p = 0.0381) were associated with less HIV-1 X4-tropism. The baseline CD4+ T cell count was a positive factor (p &lt; 0.0001) in the recovery of CD4+ T cell count during HAART.ConclusionR5-tropism represented the majority in low-level viral load HIV-1 infections receiving HAART for more than 6 months in Guangdong, China. The baseline immune level in the HIV-1 R5-tropic infections was higher than that in the X4-tropic infections. The amino acids of the 8th, 11th, and 18th of the HIV-1 V3 loop were more variable in the X4-tropic HIV-1. CRF01_AE, CRF55_01B, and lower baseline CD4+ T cell count were associated with more HIV-1 X4-tropism. The immune recovery during HAART was positively related to baseline CD4+ T cell count.
Global patterns of plant and microbial biomass in response to CO2 fumigation
Authors: Zou Junliang , Zhang Weiwei , Zhang Yun , Wu Juying 
Published: April 2023

IntroductionThe stimulation of plant and microbial growth has been widely observed as a result of elevated CO2 concentrations (eCO2), however, this stimulation could be influenced by various factors and their relative importance remains unclear.MethodsA global meta-analysis was performed using 884 lines of observations collected from published papers, which analyzed the eCO2 impact on plant and microbial biomass.ResultsA significant positive impact of eCO2 was observed on various biomass measures, including aboveground biomass (20.5%), belowground biomass (42.6%), soil microbial biomass (10.4%), fungal biomass (11.0%), and bacterial biomass (9.2%). It was found that eCO2 levels above 200 ppm had a greater impact on plant biomass compared to concentrations at or below 200 ppm. On the other hand, studies showed that positive effects on microbial biomass were more prominent at lower eCO2 levels (≤200 ppm) than at higher levels (&gt;200 ppm), which could be explained by soil nitrogen limitations. Importantly, our results indicated that aboveground biomass was controlled more by climatic and experimental conditions, while soil properties strongly impacted the stimulation of belowground and microbial biomass.DiscussionOur results provided evidence of the eCO2 fertilization effect across various ecosystem types, experimental methods, and climates, and provided a quantitative estimate of plant and soil microbial biomass sensitivity to eCO2. The results obtained in this study suggest that ecosystem models should consider climatic and edaphic factors to more accurately predict the effects of global climate change and their impact on ecosystem functions.
Clinical value of the systemic immune-inflammation index in moyamoya disease
Authors: Liu Erheng , Liu Chengyuan , Jin Lide , Zhou Hu , Tan Xueyi , Zhang Guibo , Tao Weihua , Gao Xiang , Zhao Heng , Luo Chao , Li Xuehua , Yang Shuaifeng 
Published: April 2023

BackgroundMoyamoya disease (MMD) is a rare cerebrovascular disorder with unknown etiology. The underlying pathophysiological mechanism of moyamoya disease remains to be elucidated, but recent studies have increasingly highlighted that abnormal immune response may be a potential trigger for MMD. Neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and systemic immune-inflammation index (SII) are inflammatory markers that can reflect the immune-inflammation state of the disease.ObjectiveThe purpose of this study was to investigate SII, NLR, and PLR in patients with moyamoya disease.MethodsA total of 154 patients with moyamoya disease (MMD group) and 321 age- and sex-matched healthy subjects (control group) were included in this retrospective case–control study. Complete blood count parameters were assayed to calculate the SII, NLR, and PLR values.ResultsThe SII, NLR, and PLR values in the moyamoya disease group were significantly higher than those in the control group [754 ± 499 vs. 411 ± 205 (P &lt; 0.001), 2.83 ± 1.98 vs. 1.81 ± 0.72 (P &lt; 0.001), and 152 ± 64 vs. 120 ± 42 (P &lt; 0.001), respectively]. The SII in the medium-moyamoya vessels of moyamoya disease was higher than that in the high-moyamoya vessels and low-moyamoya vessels (P = 0.005). Using the receiver operating characteristic (ROC) curve analysis to predict MMD, the highest area under the curve (AUC) was determined for SII (0.76 for SII, 0.69 for NLR, and 0.66 for PLR).ConclusionBased on the results of this study, patients with moyamoya disease admitted for inpatient care due to acute or chronic stroke have significantly higher SII, NLR, and PLR when compared to blood samples drawn from completely healthy controls in a non-emergent outpatient setting. While the findings may suggest that inflammation plays a role in moyamoya disease, further studies are warranted to corroborate such an association. In the middle stage of moyamoya disease, there may be a more intense imbalance of immune inflammation. Further studies are needed to determine whether the SII index contributes to the diagnosis or serves as a potential marker of an inflammatory response in patients with moyamoya disease.
Feasibility of hemispatial neglect rehabilitation with virtual reality-based visual exploration therapy among patients with stroke: randomised controlled trial
Authors: Shin Joon-Ho , Kim Mingyu , Lee Ji-Yeong , Kim Mi-Young , Jeon Yu-Jin , Kim Kwanguk 
Published: April 2023

BackgroundHemispatial neglect (HSN) was diagnosed using a virtual reality-based test (FOPR test) that explores the field of perception (FOP) and field of regard (FOR). Here, we developed virtual reality-visual exploration therapy (VR-VET) combining elements from the FOPR test and visual exploration therapy (VET) and examined its efficacy for HSN rehabilitation following stroke.MethodsEleven participants were randomly assigned to different groups, training with VR-VET first then waiting without VR-VET training (TW), or vice versa (WT). The TW group completed 20 sessions of a VR-VET program using a head-mounted display followed by 4 weeks of waiting, while the WT group completed the opposite regimen. Clinical HSN measurements [line bisection test (LBT), star cancellation test (SCT), Catherine Bergego Scale (CBS), CBS perceptual-attentional (CBS-PA), and CBS motor-explanatory (CBS-ME)] and FOPR tests [response time (RT), success rate (SR), and head movement (HM) for both FOP and FOR] were assessed by blinded face-to-face assessments.ResultsFive and six participants were allocated to the TW and WT groups, respectively, and no dropout occurred throughout the study. VR-VET considerably improved LBT scores, FOR variables (FOR-RT, FOR-SR), FOP-LEFT variables (FOP-LEFT-RT, FOP-LEFT-SR), and FOR-LEFT variables (FOR-LEFT-RT, FOR-LEFT-SR) compared to waiting without VR-VET. Additionally, VR-VET extensively improved FOP-SR, CBS, and CBS-PA, where waiting failed to make a significant change. The VR-VET made more improvements in the left hemispace than in the right hemispace in FOP-RT, FOP-SR, FOR-RT, and FOR-SR.ConclusionThe observed improvements in clinical assessments and FOPR tests represent the translatability of these improvements to real-world function and the multi-dimensional effects of VR-VET training.Clinical trial registrationhttps://clinicaltrials.gov/ct2/show/NCT03463122, identifier NCT03463122.
Development and validation of nomograms to predict the survival probability and occurrence of a second primary malignancy of male breast cancer patients: a population-based analysis
Authors: Huang Haowei , Li Zhuoran , Huang Zhisheng , Huang Lang , Liu Wei , Liu Guolong , Mo Yuzhen 
Published: April 2023

BackgroundMale breast cancer (MBC) is rare, which has restricted prospective research among MBC patients. With effective treatments, the prognosis of MBC patients has improved and developing a second primary malignancy (SPM) has become a life-threatening event for MBC survivors. However, few studies have focused on the prognosis of MBC patients and looked into the SPM issue in MBC survivors.MethodWe reviewed MBC patients diagnosed between 1990 and 2016 from the latest Surveillance, Epidemiology, and End Results (SEER) Plus database. Competing risk models and nomograms were conducted for predicting the risk of cancer-specific death and SPM occurrence. C-indexes, calibration curves, ROC curves, and decision curve analysis (DCA) curves were applied for validation.ResultA total of 1,843 MBC patients with complete information were finally enrolled and 60 (3.26%) had developed an SPM. Prostate cancer (40%) was the most common SPM. The median OS of all the enrolled patients was 102.41 months, while the median latency from the initial MBC diagnosis to the subsequent diagnosis of SPM was 67.2 months. The patients who suffered from an SPM shared a longer OS than those patients with only one MBC (p = 0.027). The patients were randomly divided into the development cohort and the validation cohort (at a ratio of 7:3). The Fine and Gray competing risk model was used to identify the risk factors. Two nomograms were constructed and validated to predict the 5-year, 8-year, and 10-year survival probability of MBC patients, both of which had good performance in the C-index, ROC curves, calibration plots, and DCA curves, showing the ideal discrimination capability and predictive value clinically. Furthermore, we, for the first time, constructed a nomogram based on the competing risk model to predict the 5-year, 8-year, and 10-year probability of developing an SPM in MBC survivors, which also showed good discrimination, calibration, and clinical effectiveness.ConclusionWe, for the first time, included treatment information and clinical parameters to construct a nomogram to predict not only the survival probability of MBC patients but also the probability of developing an SPM in MBC survivors, which were helpful in individual risk estimation, patient follow-up, and counseling in MBC patients.
Clinical effect of rhubarb on the treatment of chronic renal failure: A meta-analysis
Authors: Huang Wei , Rao Yanling , Li Liang , Li Chengyin , An Yi 
Published: April 2023

Objective: 1) To evaluate the effificacy of rhubarb in the treatment of chronic renal failure (CRF); 2) To explore the safety for rhubarb-based therapy on chronic renal failure.Methods: The randomized and semi randomized controlled trials of Rhubarb in the treatment of chronic renal failure in medical electronic databases (up to September 2021) were searched, and meta-analysis was carried out by revman 5.3 software.Results: A total of 2,786 patients were included in 34 literatures, including 1,474 cases in the treatment group and 1,312 cases in the control group. The results of meta-analysis showed that Serum creatinine (SCR) [MD = 123.57, 95% Cl (111.59, 131.96)], Blood urea nitrogen (BUN) [MD = −3.26, 95% Cl (−4.22,−2.31)], Creatinine clearance rate (CCR) [MD = 3.95, 95% Cl (−0.03, 7.93)], Hemoglobin (Hb) [MD = 7.70, 95% Cl (−0.18, 15.58)] and Uric acid (UA) [MD = −42.79, 95% CI (−66.29, −19.29)]. The total effective rate of improving symptoms and signs in chronic renal failure patients [Peto or = 4.14, 95% Cl (3.32, 5.16)].Conclusion: This systematic review and meta-analysis demonstrated that rhubarb has a positive therapeutic effect, which may provide confifidence and some theoretical reference for clinical application to a certain extent. Compared with the control group, rhubarb alone or traditional Chinese medicine compound containing Rhubarb can significantly reduce Serum creatinine, Blood urea nitrogen and Uric acid, increase Creatinine clearance rate, and improve the total effective rate of symptoms and signs. However, there is no evidence that rhubarb is more effective than the control group in increasing hemoglobin. In addition, due to the low quality of research methodology in the included literature, it is necessary to further study high-quality literature to evaluate its efficacy and safety.Systematic Review Registration:https://inplasy.com/inplasy-2021-10-0052/, identifier INPLASY2021100052.
Detection of limited-energy α particles using CR-39 in laser-induced p −11B reaction
Authors: Wang Putong , Deng Xiangai , Ma Zhiguo , Fu Changbo , Fan Lulin , Wang Qingsong , Xu Jiancai , Xu Tongjun , Ji Liangliang , Shen Baifei , Liu Yancheng , Cao Xiguang , Zhang Guoqiang , Ma Yugang 
Published: April 2023

Due to the harsh radiation environment produced by strong laser plasma, most of the detectors based on semiconductors cannot perform well. So, it is important to develop new detecting techniques with higher detection thresholds and highly charged particle resolution for investigating nuclear fusion reactions in laser-plasma environments. The Columbia Resin No. 39 (CR-39) detector is mainly sensitive to ions and insensitive to the backgrounds, such as electrons and photons. The detector has been widely used to detect charged particles in laser-plasma environments. In this work, we used a potassium–ethanol–water (PEW) etching solution to reduce the proton sensitivity of CR-39, by raising the detection threshold for the research of laser-induced 11B(p, α)2α reaction. We calibrated the 3–5 MeV α particles in an etching condition of 60°C PEW-25 solution (17% KOH + 25%C2H5OH + 58%H2O) and compared them with the manufacturer’s recommended etching conditions of 6.25 N NaOH aqueous solution at 98°C in our laser-induced nuclear reaction experiment. The results indicate, with the PEW-25 solution, that CR-39 is more suitable to distinguish α tracks from the proton background in our experiment. We also present a method to estimate the minimum detection range of α energy on specific etching conditions in our experiment.
Realizing strong photon blockade at exceptional points in the weak coupling regime
Authors: Li Zigeng , Li Xiaomiao , Zhang Guofeng , Zhong Xiaolan 
Published: April 2023

We theoretically prove that it is possible to realize strong photon blockade at n-order exceptional points (EPn) in a two-level quantum emitter (QE)–cavity quantum electrodynamics (QED) system even if the emitter–cavity coupling strength is weak. When the single-mode cavity is gain, we show that the ultrastrong single-photon blockade (1 PB) emerges at two-order exceptional points (EP2), avoiding the strong non-linearity of the system. In addition, we first give the pseudo-Hermitian condition for the non-Hermitian cavity QED system and find that the third-order exceptional points (EP3) can be predicted under certain constraints of the parameters. For this case, the pronounced 1 PB at EP3 will be triggered. Furthermore, we also consider the usual EP2-enhanced 1 PB existing in the system with or without the dipole–dipole interaction (DDI) under the pseudo-Hermitian condition. A striking feature is that the system without DDI can realize more obvious 1 PB at EP2 than the case of with DDI. What is important is that both EP2 and EP3 will appear in the weak coupling regime. Our proposal sheds new light on strong EP-engineered photon blockade in the weak coupling regime, providing a unique platform for making high-quality single-photon sources.