bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChatClimate: Grounding Conversational AI in Climate Science
Authors: Muccione Veruska , Stammbach Dominik , Ni Jingwei , Kraus Mathias , Bingler Julia , Allen Simon , Colesanti-Senni Chiara , Wekhof Tobias , Schimanski Tobias , Gostlow Glen , Webersinke Nicolas , Huggel Christian , Wang Qian , Yu Tingyu , Leippold Markus , Vaghefi Saeid 
Published: May 2023

Abstract
Large Language Models (LLMs) have made significant progress in recent years, achieving remarkable results in question-answering tasks (QA). However, they still face two major challenges at inference time: hallucination and outdated information. These challenges take center stage in critical domains like climate change, where obtaining accurate and up-to-date information from reliable sources in a timely fashion is essential. To overcome these barriers, one potential solution is to provide LLMs with access to external, scientifically accurate, and robust sources (long-term memory). This access assists LLMs in continuously updating their knowledge and preventing the propagation of inaccurate, incorrect, or outdated information. In this study, we enhanced GPT-4 by providing it access to the Sixth Assessment Report of the Intergovernmental (IPCC-AR6), the most comprehensive, up-to-date, and reliable source in this domain. We present our conversational AI prototype, available at www.chatclimate.ai. The product answers challenging questions accurately in three different QA scenarios: asking from 1) GPT-4, 2) ChatClimate, and 3) hybrid ChatClimate. The answers and their sources were evaluated by a team of IPCC authors, who used their expert knowledge to score the accuracy of the answers from 1 (very-low) to 5 (very-high). The evaluation showed that the Standalone assistant provided more accurate answers.
Priming Inflammation through Type I Interferon Pathway: The Aggravating Role of ADAR1 Down-Regulation in Sepsis-Induced Lung Injury
Authors: Chen Yuanzhuo , Li Jiehua , Tan Weifeng , Sun Mingming , Wang Qingde , Peng Hu , Zhang Xiangyu 
Published: May 2023

Abstract
Objectives and design:
The objective of this prospective experimental study is to investigate the role and underlying mechanism of ADAR1 knockdown in regulating inflammation and lung injury in mice with sepsis.
Subjects:
ADAR1 TM-inducible knockout mice(ADAR1flox/flox;ER−Cre+).
Treatment:
To achieve ADAR1 knockdown, intraperitoneal injections of tamoxifen or vehicle corn oil were administered to 6- to 8-week-old mice on day 1 and day 3. After 2 days of TM treatment, sepsis was induced in mice by administering intraperitoneal injections of lipopolysaccharide (LPS).
Methods
ADAR1 inducible knockout mice and bone marrow-derived macrophages (BMDMs) were used for this study. Tamoxifen treatment was administered to induce ADAR1 knockdown, and LPS was injected to induce sepsis in mice. The cecal ligation and puncture model was also used.
Results
ADAR1 increase worsened sepsis in mice and patients. Knockdown led to increased mortality and lung injury, as well as elevated levels of inflammatory cytokines.
Conclusions
ADAR1 is crucial in regulating inflammation and lung injury in sepsis. Decrease of ADAR1 expression level activates type I interferon signaling pathways and increase inflammatory response, reducing LPS resistance. This study highlights ADAR1's essential role in maintaining immune inflammatory response.
Person-centered Care Assessment Tool, a focus in quality healthcare: A systematic review of psychometric properties
Authors: Bru-Luna Lluna María , Martí-Vilar Manuel , Merino-Soto César , Livia-Segovia José , Garduño-Espinosa Juan , Toledano-Toledano Filiberto 
Published: May 2023

Abstract

Background
The person-centered care (PCC) approach plays a fundamental role in ensuring quality healthcare. The Person-centered Care Assessment Tool (P-CAT) is one of the shortest and simplest tools available today to measure the PCC approac. This systematic review’s objective was to conduct a systematic review of the evidence in the validation studies of the P-CAT, taking the "Standards" as a frame of reference.
Methods
First, a systematic literature review was conducted following the PRISMA method. Second, a systematic descriptive literature review of validity tests was conducted following the "Standards" framework. The search strategy and information sources, was made through Cochrane, Web of Science (WoS), Scopus and PubMed databases were searched. Eligibility criteria and selection process, a protocol was registered in PROSPERO (CRD42022335866), and the articles had to meet inclusion criteria to be included in the systematic review.
Results
Empirical evidence indicated that these validations offer a high number of sources related to test content, internal structure for dimensionality and internal consistency. Moderate number of sources pertaining to internal structure in terms of test-retest reliability and for the relationship with other variables. And very low numbers of evidences for response processes, internal structure in measurement invariance terms, and test consequences.
Conclusions
The various validations of the P-CAT are not framed in a structured theoretical framework like the "Standards" are.This can affect clinical practice, as people's health may depend on it. The findings of this study show that validation studies continue to focus on the types of validity traditionally studied, leaving aside the interpretation of the scores in terms of their intended use.
Multi-response optimization of Mathematical, ANN, and ANFIS models using the Pareto search algorithm in combination with the I-optimal design of mixture experiments for WEDM of Inconel 718 superalloy
Authors: Hewidy Mahmoud , Salem Osama 
Published: May 2023

Abstract
Inconel 718 is a superalloy with a high nickel content that is widely used in applications requiring solid mechanical behavior and resistance to oxidation and corrosion at high temperatures. This alloy has numerous applications in manufacturing steam turbine and jet aircraft interiors, aviation sector manifolds, and rotary spindles. It can be classified as a difficult-to-cut material unsuitable for traditional machining. The purpose of this paper is to develop prediction models for a wire electrical discharge machining (WEDM) process using response surface methodology (RSM), artificial neural networks (ANN), and adaptive neuro-fuzzy inference systems (ANFIS) and to determine which model is better at making accurate predictions. Pulse_ontime, pulse_offtime, servo voltage, flushing pressure, and wire feed were considered the main factors affecting volumetric material removal rate (VMRR) and arithmetic surface roughness (Ra), which were evaluated as WEDM performance characteristics. I-optimal design made with a computer algorithm was employed to develop experimental models. The results reveal that the wire feed and pulse_ontime were the most vital factors influencing VMRR, respectively, and the most significant factor influencing Ra is the pulse_ontime. The total percentage error of the three models demonstrated that the ANN and ANFIS models are more reliable and accurate than the RSM mathematical model. Finally, multi-objective optimization using the Pareto search algorithm was used to optimize mathematical, ANN, and ANFIS models to determine the optimum WEDM process parameters for machining Inconel 718 superalloy.
Prevalence of tissue Transglutaminase Antibodies and IgA deficiency are not increased in Juvenile Idiopathic Arthritis: A case-control study.
Authors: Taneja Angela , Hersh Aimee O. , Ponder Lori , Chan Lai Hin Kimi , Rouster-Stevens Kelly A. , Tebo Anne E , Kugathasan Subra , Guthery Stephen L. , Bohnsack John F. , Prahalad Sampath 
Published: May 2023

Abstract
Background: The prevalence of Celiac Disease (CD) in Juvenile Idiopathic Arthritis (JIA) has been reported to be 0.1% to 7% in various small studies. As a result of the limited number of research and their inconclusive results there are no clear recommendations for routine CD screening in asymptomatic patients with JIA. Our aim is to estimate the prevalence of IgA deficiency and tissue transglutaminase (tTG) IgA in a cohort of JIA followed in two large academic medical centers.
Methods: Serum was collected and stored from all subjects and analyzed in a reference laboratory for total IgA (Quantitative Nephelometry) and tTG IgA antibody levels (Semi-Quantitative Enzyme-Linked Immunosorbent Assay). Fisher’s exact tests were performed for statistical significance. Risk estimates (odds ratios) with 95% confidence intervals were calculated.
Results: 808 JIA and 140 controls were analyzed. Majority were non-Hispanic whites (72% vs 68% p=ns). A total of 1.2% of cases were IgA deficient compared to none of the controls (p=0.373). After excluding IgA deficient subjects, 2% of cases had tTG IgA >4u/mL compared to 3.6% of controls (p=0.216) (OR = 0.5; 95% C.I= 0.1-1.4); and 0.8% of cases had tTG IgA >10u/mL compared to 1.4% of controls (p=0.627) (OR=0.5; 95%C.I=0.1-2.9).
Conclusions: Using the largest JIA cohort to date to investigate prevalence of celiac antibodies, the prevalence of positive tTG IgA was 0.8% and of IgA deficiency was 1.2%. The results did not demonstrate a higher prevalence of abnormal tTG IgA in JIA. The study did not support the routine screening of asymptomatic JIA patients for Celiac Disease (CD).
Transcriptional effects of carbon and nitrogen starvation on Ganoderma boninense, an oil palm phytopathogen
Authors: Nagappan Jayanthi , Ooi Siew-Eng , Chan Kuang-Lim , Kadri Faizun , Nurazah Zain , Halim Mohd Amin Ab , Sanusi Nik Shazana Nik Mohd , Angel Lee Pei Lee , Sundram Shamala , Chin Chiew Foan , May Sean T , Ong-Abdullah Meilina , Singh Rajinder , Low Eng Ti Leslie 
Published: May 2023

Abstract
Background
Ganoderma boninense is a phytopathogen of oil palm, causing basal and upper stem rot diseases.
Methods
The genome sequence was used as a reference to study gene expression during growth in a starved carbon (C) and nitrogen (N) environment with minimal sugar and sawdust as initial energy sources. This study was conducted to mimic possible limitations of the C-N nutrient sources during the growth of G. boninense in oil palm plantations.
Results
Genome sequencing of an isolate collected from a palm tree in West Malaysia generated an assembly of 67.12 Mb encoding 19,851 predicted genes. Transcriptomic analysis from a time course during growth in this starvation media identified differential expressed genes (DEGs) that were found to be associated with 30 metabolic pathways. During the active growth phase (Day2), 27 DEGs related to four pathways, including secondary metabolite biosynthesis, carbohydrate metabolism, glycan metabolism and mycotoxin biosynthesis. G. boninense genes involved in the carbohydrate metabolism pathway that contribute to the degradation of plant cell walls were up-regulated. Interestingly, several genes associated with the mycotoxin biosynthesis pathway were identified as playing a possible role in pathogen-host interaction. Several genes associated with mycotoxin biosynthesis were associated with pathogen-host interactions. In addition, metabolomics analysis revealed six metabolites, maltose, xylobiose, glucooligosaccharide, glycylproline, dimethylfumaric acid and arabitol that were up-regulated on Day2 of the time course.
Conclusions
This study provides information on genes expressed by G. boninense in metabolic pathways that may play a role in the initial infection of the host.
Success of Caries and Periapical Infection Diagnoses on Panoramic images: Artificial Intelligence vsJunior and Specialist Dentists
Authors: Güneç Hüseyin Gürkan 
Published: May 2023

Abstract
Purpose: The aim of this study is to evaluate the success rate of radiological diagnoses regarding caries and periapical infection, comparing an artificial intelligence application against junior dentists, based on the valid determinations by specialist dentists.
Methods: In the initial stage of the study, 2 specialist dentists evaluated the presence of caries and periapical lesions on 500 digital panoramic radiographs, and the detection time was recorded in seconds. In the second stage, 3 junior dentists and an artificial intelligence application performed diagnoses on the same panoramic radiographs, and the diagnostic results and durations were recorded in seconds.
Results: The artificial intelligence and the three junior dentists, respectively, detected dental caries at an SEN of 0.907,0.889,0.491,0.907; a SPEC of 0.760,0.740,0.454,0.769660; a PPV of 0.693,0.470,0.155,0.666; an NPV of 0.505,0.415,0.275,0.367 and an F1-score of 0.786,0.615,0.236,0.768. The artificial intelligence and the three junior dentists respectively detected periapical lesions at an SEN of 0.973,0.962,0.758,0.958; a SPEC of 0.629,0.421,0.404,0.621; a PPV of 0.861,0.651,0.312,0.648; an NPV of 0.689,0.673,0.278,0.546 and an F1-score of 0.914,0.777,0.442,0.773.
Conclusion: The artificial intelligence application gave more accurate results, especially in detecting periapical lesions. On the other hand, in caries detection, the underdiagnosis rate was high for both artificial intelligence and junior dentists. Regarding the evaluation time needed, artificial intelligence performed faster, on average.
Effect of corneal collagen cross linking on crystalline lens clarity graded by Pentacam Nucleus Staging Software
Authors: Fahmy Amr Ehab , Barrada Ahmed Hassan , khalil Mahmoud Mohammed Ahmed Ali 
Published: May 2023

Abstract
Background
to describe the effect of ultraviolet rays dissipated during corneal collagen crosslinking on cataract development in keratoconus patient in Cairo, Egypt.
Methods
We performed a descriptive prospective study that will assess the influence of uneventful corneal collagen crosslinking in management of keratoconus on the crystalline lens clarity in one hundred Eye by oculus pentacam nucleus staging (PNS) for patients attending the specialist eye hospital at the military medical complex of Kobri el Kobba in collaboration with Al-Azhar university hospitals diagnosed from January 2021.
Results
Our study reported that corneal collagen crosslinking has a highly significant effect in developing lens opacities specially the older age and small AC depth and reported also its affection on visual acuity.
Conclusion
Corneal collagen cross linking as a method of stabilizing keratoconus progression results in significant changes and increase in the densitometry of the crystalline lens which is a problem that increase the risk in the development of cataract, this is particularly in patient more exposed to ultraviolet rays and pre CXL high lens densitometry.
Lubrication performance of nano molybdenum disulfide as additive in drilling fluid in polycrystalline diamond compacts
Authors: Gou Ruyi , Chen Jingjing , Li Jinhe , Luo Xun 
Published: May 2023

Abstract
The effects of nano-molybdenum disulfide (nano-MoS2) in drilling fluid and drilling fluid on the tribological behavior of polycrystalline diamond compact (PDC) with cobalt leaching depth of 422µm were studied by ball-on-disk friction test, and the effects of concentration and bearing capacity were evaluated respectively. The results showed that the addition of nano-MoS2 improves the lubrication effect of drilling fluid and the friction performance of PDC. The lubrication mechanism of drilling fluid and the mechanism of adding nano-MoS2 to improve tribological properties are discussed. The results further deepen the understanding of the friction and wear mechanism of PDC in lubricating environment, and provide a theoretical reference for the application of PDC in the future petroleum field.
Comparative efficacy and safety of anti-PD-1/L1 antibody plus anti-VEGF antibody and anti-PD-1/L1 antibody plus VEGFR-targeted tyrosine kinase inhibitor as first-line therapy for unresectable hepatocellular carcinoma (uHCC): a systematic review and network meta- analysis
Authors: Zhou Yiwen , Li Jingjing , Lu Beibei , Zheng Yuxi , Ying Jieer 
Published: May 2023

Abstract
Background
Anti-PD-1/L1 antibody + anti-VEGF antibody (A + A) and anti-PD-1/L1 antibody + VEGFR-targeted tyrosine kinase inhibitor (A + T) are both effective first-line therapies for uHCC. However, direct comparisons between them are not available. We conducted a network meta-analysis of them in terms of overall survival (OS), progression free survival (PFS), objective response rate (ORR) and incidence of treatment-related adverse events (TRAEs).
Methods
After a rigorous literature research, 6 phase III trials has been identified for the final analysis: IMbrave150, ORIENT-32, COSMIC-312, CARES-310, LEAP-002 and REFLECT. The experiments were classified into three groups: A + A, A + T and intermediate reference group. We derived hazard ratios (HR) with 95% confidence intervals (95%CI) for OS and PFS, odds ratio (OR) for ORR and relative risks (RR) for all grade and ≥ 3 TRAEs. With fixed effect models to estimate the indirect pooled HRs, ORs, RRs and 95%CI, a frequentist network meta-analysis was conducted using sorafenib as intermediate reference.
Results
With a P-score of 98%, A + A provided the greatest reduction in the risk of death, without significant difference from A + T (HR = 0.84, 95%CI: 0.66–1.06). Besides, A + T showed the greatest effect in prolonging PFS and improving ORR with 91% for P-score, but there are no statistical differences with A + A(HR = 1.06, 95%CI: 0.87–1.30, OR = 0.82, 95%CI: 0.47–1.46). A + A were significantly safer than A + T (RR = 0.91, 95%CI: 0.84–0.98) in all grade of TRAEs and ≥ 3 (RR = 0.91, 95%CI: 0.84–0.98).
Conclusions
A + A has the greatest probability of delivering the longest OS, while A + T is correlated with larger PFS benefit at the cost of a lower safety rate.
Characterization of Biofilm Structures Produced by Some Plant Growth Promoting Bacteria and Their Colonization on Plant Roots
Authors: Çiftçi Tacettin , Çınarlı Murat , Erdoğan İbrahim 
Published: May 2023

Abstract
Plant growth promoting rhizobacteria (PGPR) increase plant root development and provide plants with maximum nutrient uptake opportunities for better growth. Besides promoting growth, PGPRs have a number of functions including stress tolerance (heat, drought, salinity and disease), bioremediation of heavy metals, biodegradation of complex toxic organic compounds, biocontrol agents and biofilm formation. The interaction between various plant growth promoting rhizobacteria was mainly investigated under the planktonic growth mode. In-depth investigation of biofilm development on root surface and rhizosphere colonization is needed to improve understanding of plant-microorganism interaction. In this study; The biofilm structures formed by Bacillus drentensis, Bacillus mojavensis, Pseudomonas fluorescens, Pseudomonas putida and Arthrobacter nitroguajacolicus bacteria, which have plant growth promoting properties, were characterized by Raman and FT-IR Spectroscopy. In addition, the biofilm formation capacity of these bacteria on polystyrene surfaces was determined by the crystal violet test, and the colonization of Bacillus drentensis, Pseudomonas fluorescens and Arthrobacter nitroguajacolicus bacteria on Arabidopsis thaliana Columbia ecotype roots was determined by Scanning Electron Microscope (SEM) analysis.
Best of Both Worlds? Fixation of Distal Femur Fractures with the Nail-Plate Construct. Patient-Reported Outcomes and One-Year Results in a Heterogenous Population
Authors: Pfister Benjamin , Wilson Anthony , Drobetz Herwig 
Published: May 2023

Abstract
Objectives
Distal femoral fractures are a significant injury sustained by low- and high-energy trauma. Common treatment practices are lateral locking plate or intramedullary nail fixation, with disadvantages including risk of non- and mal-union and limited post-operative weightbearing status. Combining both techniques as a nail-plate construct (NPC) theoretically achieves enhanced fixation to allow immediate weightbearing. This study examines the functional, radiographic, and patient-reported outcomes of distal femur NPC fixation.
Methods
Single-centre combined prospective and retrospective study including all patients > 18 years who sustained distal femur fractures treated with NPC. The primary outcome was radiographic union and malunion at minimum one-year follow-up. Secondary outcome measures included patient reported outcome measures, post-operative mobility, length of stay and complications.
Results
Sixteen patients were included in the study. Rate of radiographic union was 100%. There was no case of malunion. All patients were allowed to full weight bear immediately post-operatively. Mean length of stay was 9.50 days, with 37.5% of patients discharged directly home. The majority (85.7%) of patients returned to pre-injury mobility. Early post-operative complications occurred in three patients. Three patients returned to theatre. The mean EQ-5D-5L index value was 0.713, with 71.4% describing no problems with self-care and 85.7% reporting no or slight problems with usual daily activities.
Conclusions
The NPC provided stable fixation permitting full weightbearing post-operatively with no cases of non- or malunion. Return to pre-injury mobility and activity are encouraging. Based on these results we support the use of nail-plate construct fixation in the management of distal femur fractures.
The first pilot study on remote monitoring of implantable cardiac electronic devices in South Korea: rationale and study protocol of a REMOTE-CARE
Authors: Hwang YouMi , Bae Hannah 
Published: May 2023

Abstract
Background: Previous studies have demonstrated that remote cardiac device monitoring reduces unnecessary outpatient visits and increases patient satisfaction. As domestic research on remote monitoring in Korea is lacking, there is a need for more evidence in order to develop remote monitoring-related policies or insurance standards. Based on our previous research on patient requirements for remote monitoring, we designed the first Korean study on remote cardiac device monitoring, including a 1-year follow-up period, to examine the patient satisfaction, medical safety, and efficacy of remote monitoring.
Methods: The REMOTE-CARE study is a single university hospital observational survey study that will include 100 cardiac implantable electronic devices, including pacemakers (PMs), implantable cardioverter defibrillators (ICD), and cardiac resynchronisation therapy (CRT), compatible with the Biotronik Home Monitoring system. All study participants will be provided CardioMessenger Smart for remote monitoring during enrolment. Regular in-office visits will be planned every 6–12 months for patients with PM and every 3–6 months for those with ICD and those undergoing CRT. The time/medical cost efficacy and satisfaction index will be evaluated using electronic medical records during the 12-month follow-up period. Pre- and post-questionnaires will be administered before and at 1 year after remote monitoring, respectively.
Discussion: The REMOTE-CARE study is the first prospective study to provide further insights on domestic remote monitoring applications based on patient perspectives in South Korea. The study will also provide evidence for developing policy or insurance standards for remote monitoring in Korea.
Registration: The REMOTE-CARE study is registered at ClinicalTrials.gov with study ID NCT04557111. This study was approved by the Institutional Review Board (IRB) of the Catholic University of Korea St. Vincent’s Hospital (Suwon, South Korea; IRB No. VC20DISF0160).