bluuebunny/crossref_metadata_2025_split huggingface dataset:
PHYSICAL-MECHANICAL AND THERMAL DEFORMATION PROPERTIES OF PLASTICIZED HIGHLY FILLED COMPOSITES BASED ON POLYPROPYLENE AND QUARTZ
Authors: Ganbarli Zeynab A. , Azizbayli Hamida R. , Bagirova Shafaq R. 
Published: May 2023

The influence of quartz content (silicon dioxide) on the main physical-mechanical properties of composites based on polypropylene is considered. It is shown that the loading of a compatibilizer – a copolymer of polypropylene with maleic anhydride – into the composition of the composite improves the properties and compatibility of the mixed components of the mixture. Properties such as ultimate tensile stress, tensile yield strength, elongation at break, Vicat softening temperature and melt flow index were studied. The use of synthesized polyethylene wax as a plasticizer made it possible to significantly improve the deformability of highly filled composites. The quartz concentration was varied within 5.0–25 % wt., and the plasticizer concentration was 1.0–3.0 % wt. The method of thermomechanical studies shows the patterns of change in thermomechanical curves in the temperature range of 20–250 °C, depending on the concentration of quartz, plasticizer and vulcanizing agent. The complex of studies carried out has opened up new possibilities for strengthening composites and increasing their Vicat softening temperature.
Genetic heterogeneity of congenital cerebral palsy and the concept of the neurotropic genome
Authors: Sokolov P. L. , Chebanenko N. V. , Prityko A. G. , Romanov P. A. 
Published: May 2023

Background. Currently, more than 500 genes are known, in one degree or another associated with the development of the phenotype of congenital cerebral palsy (CP). The amount of accumulated data requires the sorting of the mechanisms of the influence of genes on brain development.Aim. To compare the spectrum of determinants in groups of patients with CP, accompanied (CP+) and non-accompanied (CP–) by epilepsy.Materials and methods. 154 children with a phenotype of cerebral palsy aged from 1 to 17 years old were investigated. Boys – 92, girls – 62. Genetic mutations were confirmed by the methods of next generation sequencing (NGS) in the study of venous blood samples. Genes with anomalies were distributed to the groups of determinants for the main aspects of the development and function of the brain. A total of 13 groups were created.Results. In the CP– group, determinants of cell dividing, brain development and cytoskeleton were identified in 11 (61.1 %) cases. In 4 (22.2 %) cases, determinants of cell metabolism and external cell membrane transport were identified. In the CP+ group in 23.5 % of cases, determinants of cell division, brain development and cytoskeleton were revealed. The number of patients with anomalies of chromatin modifications, transcription and replication processes was significantly less (4.4 %). In 42 (30.8 %), the CP+ patients found determinants of excitability of the neuronal membrane and excitation transmission. In the cases of brain malformations in both CP– and CP+ groups determinants of cellular division, brain development and cytoskeleton were identified. Interest caused cases of brain malformations with anomalies of genes of the channelopathy.Conclusions. Our data suggests the difference between pathogenetic models CP+ and CP–. The fundamental difference of them is the presence of genes regulating the excitability of the neuronal membrane in CP+ group.
A COMUNICAÇÃO EFETIVA NO ALCANCE DE PRÁTICAS SEGURAS: CONCEPÇÕES E PRÁTICAS
Authors: Castro Juliana de Viana Rodrigues , Amaro Marilane de Oliveira Fani , Mendonça Érica Toledo , Siman Andréia Guerra , Zanelli Fernando Pacheco , Carvalho Camilo Amaro de 
Published: May 2023

Objetivo: Analisar as ações realizadas e os desafios da equipe de enfermagem para alcançar a meta de segurança de comunicação efetiva em um centro cirúrgico de um hospital de ensino. Método: Estudo de caso com abordagem qualitativa, realizado com a equipe de enfermagem nos meses de janeiro e fevereiro de 2019. A coleta de dados ocorreu através de entrevistas com roteiro semiestruturado, tendo sido submetidas a análise de conteúdo. Resultados: Evidenciaram-se três categorias temáticas: Comunicação na concepção da equipe de enfermagem: importância e instrumentos utilizados; Comunicação efetiva: desafios vivenciados e repercussões na assistência de enfermagem; Benefícios da comunicação entre profissional de saúde e paciente: construindo vínculo e confiança. Conclusões: Foram identificados alguns desafios como ausência de reuniões, falta de escuta qualificada e sobrecarga de trabalho, os quais podem favorecer a ocorrência de erros, interferindo, na segurança do paciente. Urge a necessidade de sistematizar o processo de comunicação no local pesquisado.
Materi Alat dan Metode Pembelajaran Dalam Sistem Pendidikan Islam di Era Digital
Authors: Sugiyono Sugiyono , Khojir Khojir 
Published: May 2023

Abstract
Innovation in the Islamic education system in the midst of the speed of change in the digital era as a necessity, adequate learning tools in the form of materials, tools and methods are indispensable in improving the quality of Islamic education. The purpose of this research is to describe views about the nature of materials, tools, and learning methods in the Islamic education system in the digital era. The type of research is literature with data analysis techniques of descriptive type with data collection from the google schoolar application. The results of the study illustrate that most researchers have a view of the nature of materials, tools and methods as a mechanism to achieve quality educational goals, which are supported through the integration of the values ​​of the Qur'an and hadith and the use of information technology in them.

Keywords: Materials, Tools, Methods, Digital Era
Abstrak :
Inovasi dalam sistem pendidikan Islam di tengah kecepatan perubahan di era digital sebagai sebuah keniscayaan, perangkat pembelajaran yang memadai dalam bentuk materi, alat dan metode sangat diperlukan dalam meningkatkan mutu pendidikan Islam. Tujuan penelitian untuk mendeskripsikan pandangan tentang hakikat materi, alat, dan metode pembelajaran dalam sistem pendidikan Islam di era digital. Penelitian berjenis kepustakaan dengan teknik analisis data berjenis dekriptif analisis dengan pengumpulan data dari aplikasi google schoolar. Hasil penelitian menggambarkan bahwa sebagian besar peneliti memiliki pandangan tentang hakikat materi, alat dan metode sebagai mekanisme untuk mencapai tujuan pendidikan yang berkualitas, yang didukung melalui pengintegrasian nilai-nilai Al-Qur'an dan hadits dan pemanfaatan teknologi informasi di dalamnya.
Kata kunci: Bahan, Alat, Metode, Era digital
Phenotypic and Genetic Characterization of children with Wilson Disease from Northeast China
Authors: Zhang Tianhe , Song Wenliang , Mao Zhiqin 
Published: May 2023

AbstractBackground Wilson's disease (WD) is an autosomal recessive genetic disease caused by ATP7B gene mutations and characterized by copper metabolism disorders. Objective This study aimed to highlight the phenotypic and genetic characteristics of children with WD in Northeast China. Methods We retrospectively analyzed clinical data and gene sequencing results of 65 children with WD from January 1, 2014 to December 31, 2022 in Shengjing Hospital of China Medical University. Results The mean age at the time of the diagnosis of WD was 6.3 ± 3.52 years (range 1.2–15 years). Fifty cases (50/65, 76.9%) were asymptomatic and only found abnormal liver function during physical examination. However, they had negative Kayser–Fleischer (KF) ring with significant difference (p < 0.05). Children with acute liver failure had significantly elevated 24hr urinary Cu excretion (p < 0.05). We detected a total of 46 gene mutations in ATP7B gene, including 7 novel mutations. The most frequent mutation was p.R778L with an allelic frequency of 38.7%. Phenotype–genotype correlation analysis suggested that p.R778L was significantly associated with lower levels of serum ceruloplasmin and higher zinc levels (p < 0.05). LOF (loss of function) mutation was significantly associated lower albumin (p < 0.05). Conclusion Most children with WD are asymptomatic, which makes early diagnosis of WD challenging, and it is necessary to perform genetic test. p.R778L is the most frequently mutation of ATP7B gene in China and may play an important role in lower levels of serum ceruloplasmin.
A specific new analytical method for determining linagliptin in pure and combination drug products (Empagliflozin and Metformin)
Authors: Sahloul Lujain , Salami Maisam 
Published: May 2023

Abstract

Linagliptin is an oral antidiabetic agent, used to treat type 2 diabetes. It is taken orally independently or in combination with Empagliflozin and Metformin HCl. Chromatographic Analysis methods were demonstrated for simultaneous analysis of two or three antidiabetic drugs (Linagliptin, Empagliflozin and/or Metformin). This article is interested in the validation of a simple, fast and specific method that relies on chemical derivatization and uses a VIS spectrophotometer to determine LINA in pure and combination drug products alongside Empagliflozin and Metformin. The developed method was reached by reacting LNG with Para-Dimethylaminobenzaldehyde (PDAB) 5% in an acidic medium (Hydrochloride 37%) in a water bath to produce a yellow Schiff base which can be measured at a wavelength of 407 nm. The developed method has good accuracy and precision. PDAB does not interact with Empagliflozin or Metformin under these optimal conditions. Therefore, this developed method is distinguished by its accuracy and specificity in assaying Linagliptin both alone and in combination drug products.
The experience of young stroke survivors: An interpretative phenomenological study
Authors: Thompson Claire , Moss Simon Andrew , Hooper Mary-Ellen , Kurz Ella , Ladbrook Elyse , Bushell Mary 
Published: May 2023

Abstract
Background: While stroke is becoming increasingly prevalent in young people (<65 years), diagnosis, treatment, rehabilitation, and management continue to reflect the needs of older people. Health services are not accommodating young stroke survivors' distinct needs, trajectories, preferences, and risk factors.
Objectives: The purpose of this study was to characterise and appreciate the experience of young stroke survivors.
Methods: Qualitative in-depth semi-structured interviews were conducted with 11 stroke survivors aged between 18 and 49 (via virtual conferencing software). Interview data were analysed using interpretative phenomenological analysis.
Results: Young stroke survivors experience a sense of alienation when healthcare providers imply their stroke is an anomaly and are surrounded by elderly patients in stroke units. Alienation and additional emotional concerns, coupled with memory and communication difficulties, compromised survivors’ sense of agency. Many participants also developed and exhibited resilience, gratitude, and acceptance, preserving their mental health.
Conclusions: The experience of young stroke survivors is distinct. By considering the unique trajectory of young stroke survivors, health services will be better able to facilitate the rehabilitation of this population.
Mutation Analysis and Characteristics of the 5T Allele in the Cystic Fibrosis Trans Membrane Gene
Authors: mafruchati maslichah , Ismail Wan Iryani Wan 
Published: May 2023

Abstract
Mutation in cystic fibrosis was associated with the T allele, causing abnormalities in mRNA of cystic fivbrosis and on Congenital Bivariate vas Deferens (CBAVD). Purpose of this paperwas to determine mutations in the 5T allele in the cystic fibrosis trans membranegene. This study used 500 married men with CBAVD who had regular sex reported being infertile as samples. All of the patients shared these traits, including impalpability of the scrotal vas deferens, low volume and pH levels in the semen. DNA was extracted in the laboratory from 3–5 ml of pre-processed blood lymphocytes. The next steps are gel-gradient electrophoresis, PCR, and extraction. It was discovered that the 5T allele had a mutation. From the results of the research conducted, mutations or changes in amino acids were found in the 5T allele and cystic fibrosis trans membrane. Information on the frequency of the 5T allele in various populations of sample was available. Other visible result were the cystic fibrosis trans membrane Intron 8 gene PCR outcomes.
Widespread CO2 and CO in the Trans-Neptunian Population revealed by JWST/DiSCo-TNOs
Authors: Hénault Elsa , Pinilla-Alonso Noemi , Holler Bryan , Brunetto Rosario , Feliciano Ana Carolina de Souza , Stansberry John , Harvison Brittany , Müller Thomas , Bannister Michele , Cruikshank Dale , Emery Joshua , Guilbert-Lepoutre Aurélie , Licandro Javier , Lorenzi Vania , Peixinho Nuno , Pendleton Yvonne , Schambeau Charles , De Pra Mario 
Published: May 2023

Abstract

Carbon dioxide (CO2) is one of the most abundant ices in the solar system. It has been detected in giant planet atmospheres and on their moons, on and around comets, and even in regions of Mercury, the Moon, and Mars. However, despite their formation in the coldest regions of the protoplanetary disk, CO2 was not previously detected on trans-Neptunian objects (TNOs). Carbon monoxide (CO) was only expected to be present in the largest TNOs. Out of 45 total, we report the detection of both CO2 and CO in 42 and 24 TNOs, respectively, observed with the NIRSpec instrument on the JWST by the DiSCo-TNOs project (PID 2418). Our analysis shows that \diox is widespread in the trans-Neptunian region, independent of dynamical class, while CO is a common constituent of the reddest objects in our sample. The abundance and characteristics of \diox suggest that most of it could be primordially accreted. While, CO is probably being produced by ion irradiation of CO2 and other C-bearing species. Our results suggest the prevalence of two compositional groups among TNOs based on the abundance and properties of CO2 and CO. We discuss the implication of these results in the context of solar system formation.
Expression of the cGAS-STING pathway is associated with high levels of genomic instability and immune cell infiltration in breast cancer
Authors: Chen Mengting , Yu Shibo , Sluis Tineke van der , Zwager Mieke , Schröder Carolien , Vegt Bert Van der , Vugt Marcel van 
Published: May 2023

Abstract
Genomic instability is a hallmark of cancer, and can be caused by oncogene-induced replication stress. Besides driving the evolution of cancer genomes, genomic instability can lead to the activation of inflammatory signaling, involving the cGAS-STING and JAK-STAT pathways. Inflammatory signaling has been associated with pro-tumorigenic features, but has also been associated with favorable response to treatment, including to immune checkpoint inhibitors. To improve our understanding of the relations between genomic instability and to ultimately guide patient selection for treatment, we investigated the cGAS-STING pathway in relation to markers of replication stress and immune cell infiltration in breast cancer. Immunohistochemistry was performed to determine the expression of cGAS-STING signaling components (STING, phospho-TBK1, and phospho-STAT1), replication stress markers (γH2AX and phospho-RPA32), replication stress-related oncogenes (Cyclin E1 and c-Myc) and immune cell markers (CD20, CD4, and CD57) on primary breast cancer samples (n = 380). Clinical data and mRNA expression data from two public breast cancer databases (TCGA and METABRIC) and an immune therapy trial (I-SPY2) were used to investigate the correlation between cGAS-STING pathway activation, genomic instability markers and patient response to immune therapy. We find that phospho-TBK1, and phospho-STAT1 were highly expressed in triple-negative breast cancers (TNBCs). In addition, expression of genomic instability markers γH2AX and pRPA, replication stress-related oncogenes Cyclin E1 and c-Myc, and immune cell markers were all positively correlated with phospho-STAT1 expression (P < 0.001). We also found that phospho-TBK1 was positively associated with γH2AX (P < 0.002), c-Myc (P < 0.001), CD4 (P < 0.001) and CD20 (P < 0.05). Besides, a positive correlation between perinuclear STING and CD4 was observed (P < 0.01). Accordingly, cGAS-STING pathway components also showed the highest expression levels in TNBCs in both TCGA and METABRIC cohorts. Also, cGAS-STING scores were significantly positively correlated with metrics of genomic instability, including homologous recombination deficiency (HRD) (TCGA: r = 0.296, P < 0.001) and tumor mutational burden (TMB) (TCGA: r = 0.254, P < 0.001; METABRIC: r = 0.0632, P < 0.01). Moreover, higher expression of the cGAS-STING score was also observed in patients who responded to immunotherapy. In conclusion, our study shows that the cGAS-STING pathway is highly expressed in TNBCs, and is positively correlated with genomic instability and immune cell infiltration.
Environmental Factors and Distribution of Tree Species in Wetlands Eastern Amazon, Brazil
Authors: Carim Marcelo de Jesus Veiga , Wittmann Florian Karl , Piedade Maria Teresa Fernandez , Steege Hans Ter , Torres Admilson Moreira , Junior Orleno Marques da Silva , de Oliveira Cinthia Pereira , Vasconcelos Caroline da Cruz , Aparaício Perseu da Silva , de Lima Robson Borges 
Published: May 2023

Abstract
This article analyzes the influence of environmental factors and their correlations on the distribution of tree species, which is an efficient way to understand the differences in composition and richness between forest ecosystems. Although many works have traced an efficient profile in an attempt to describe the composition and species richness associated with environmental factors and the flooding regime throughout the Amazon, few have portrayed these relationships between tidal floodplain and igapo forests in the Amazon estuarine. We analyze the influence of environmental factors in soil (physical and chemical) and the flooding period on the distribution, composition and richness of tree species. The examined forests were systematically evaluated in 26 ha− 1, divided equally between them. All trees (DBH ≥ 10 cm) were recorded, and principal component analysis (PCA) was employed as a way of assessing the associations of environmental variables and species distribution. The environmental variables responded differently for each type of forest, showing some consistency with the peculiar characteristics of each environment; in the igapo forest, acidity, aluminum concentration, flood duration, potassium and sand content affected species distribution, while CEC, SB, silt, Ca, flood duration, pH, K, and P content did so in the floodplain. Notably, the forests presented similar structures. Nevertheless, the igapo forest presented three times more species richness than the floodplain. We suggest that the distribution of species responds to environmental factors in a very particular way, allowing each environment to establish greater efficiency in the use of its resources.
Experimental study on physical intervention of Virtual Reality cycling on simple obese college students
Authors: Zhao Meng , Lei Ying , Wei Ziran , You Ming , Chen Lei 
Published: May 2023

Abstract
Purpose
The aim of this study was to investigate the effectiveness of Virtual Reality (VR) cycling as an intervention for physique improvement in simple obese college students.
Methods
A literature review, questionnaire survey, and 12-week experimental comparison were conducted using mathematical statistical methods on 41 simple obese college students in Nanjing, China.
Results
The results showed that 12 weeks of VR cycling had a significant effect on fat loss and shaping in simple obese college students. The weight, BMI, waist circumference, hip circumference, and waist-to-body ratio decreased by 5.25%, 5.22%, 4.44%, 2.44%, and 2.1%, respectively, while lung capacity increased by 9.15%. Significant differences were observed within 10%, 5%, and 1%. Moreover, there were gender-based differences in the morphological changes. Men's abdominal fat consumption was slightly greater than that of women, resulting in a significant reduction in the waist and buttocks of men compared to women.
Conclusion
The study concludes that VR cycling is a more engaging and interesting intervention for fat loss and shaping than traditional aerobic exercise. By adjusting the exercise time and course difficulty, participants are more likely to adhere to the exercise regimen, leading to significant weight loss and other positive outcomes. The results of this study could be useful for designing effective interventions to improve the physique of obese individuals.
Identification and Validation of a Prognostic Model Based on Five Copper Metabolism-related Genes in Hepatocellular Carcinoma
Authors: Luo Rui , Xu Huan , Huang Shu , Peng Jieyu , Shi Xiaomin , Zhang Wei , Shi Lei , Zhong Xiaolin , Peng Yan , Lü Muhan , Tang Xiaowei 
Published: May 2023

Abstract
objective Hepatocellular carcinoma (HCC) is a prevalent malignancy, with high mortality and easy recurrence. Copper metabolism regulates tumor’s development and progression via several biological pathway and has significant clinical value in HCC. Thus, we identified potential gene biomarkers related to copper metabolism to establish a novel predictive model to predict the survival of HCC patients.Methods Our research utilized various statistical analysis methods to construct a new model to predict the prognosis of HCC. The LASSO-COX algorithm shrank the coefficients of the predictive factor. The construction of the model was in Cancer Genome Atlas (TCGA), and the validation was in International Cancer Genome Consortium (ICGC) cohort. We performed GO and KEGG analyses to enrich the function annotations of the selected genes. The nomogram and receiver operating characteristic (ROC) curve analysis were used to evaluate the model's performance.Results A risk-predictive scoring model of 5 copper metabolism-related genes (AOC1, LOX, STEAP4, MAPT, and LCAT) was constructed by the data from TCGA after LASSO-COX regression analysis and validated by the data from ICGC. Moreover, GO and KEGG analyses of the predictive signature revealed that the signature was mainly associated with copper ion binding, metal ion, oxidoreductase activity acting on the CH-NH2 group of donors, and tryptophan metabolism. The OS of the high-risk group was significantly lower than that of the low-risk group. Time-dependent ROC evaluated the performance of this model with AUC values for 1, 2, and 3 years of 0.749, 0.741, and 0.723 in OS, respectively. The nomogram, combining the risk score and clinical features, showed a solid prognostic ability in HCC.Conclusion A reliable predictive score model was constructed, which could be a valuable prognostic indicator and a clinical treatment selection guiding in HCC with 5 CMRGs.