bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enhanced empathic pain by facial feedback
Authors: Lee Seoyoung , Yoo Yeonjoo , Moon Heeyoung , Lee In-Seon , Chae Younbyoung 
Published: December 2022

Abstract
Objectives
Based on the facial feedback hypothesis, the purpose of this study was to determine whether enhancing negative emotion by activating a facial muscle (corrugator supercilii) increases the intensity of cognitive and emotional components of empathic pain. We also assessed whether the muscle contraction changed the pupil size, which would indicate a higher level of arousal.
Methods
Forty-eight individuals completed 40 muscular contraction and relaxation trials while looking at images of five male and five female patients with neutral and painful facial expressions, respectively. Participants were asked to rate (1) how much pain the patient was in, and (2) how unpleasant their own feelings were. We also examined their facial muscle activities and changes in pupil size.
Results
No significant differences in pain or unpleasantness ratings were detected for the neutral face between the two conditions; however, the pain and unpleasantness ratings for the painful face were considerably higher in the contraction than relaxation condition. The pupils were considerably larger in the contraction than relaxation condition for both the painful and neutral faces.
Conclusion
Our findings indicate that, by strengthening the corrugator supercilii, facial feedback can affect both the cognitive evaluative and affective sharing aspects of empathic pain.
The impact of internet use on the subjective well-being of the elderly: New evidence from the China Family Panel Studies
Authors: Yuan Ziqi , Jia Guozhu 
Published: December 2022

Abstract
With the widespread availability of 5G technology in China, the internet has deeply affected the lives of the elderly. This research analyzes the impact of internet use on subjective well-being (SWB) of the elderly using the latest 2020 China Family Panel Studies (CFPS) data through machine learning (ML) techniques and traditional regression models. (1) Machine learning findings indicate that the factors order of importance from strong to weak is the internet as an information channel, contact with family and friends, and work, leisure and entertainment, daily life and using WeChat, watching online short videos and learning. (2) Ordinary least squares (OLS) regression results show the internet for daily life and watching short-form videos have a significant negative effect on the SWB of the elderly. (3) XGBoost with determination coefficients (R2) greater than 0.86 is significantly outperformed the OLS with determination coefficients of 0.35 in full sample sets. This work proves that the combination of machine learning and traditional regression methods can both take advantage of the interpretability of machine learning and reveal factors contributions through traditional regression models, having the ability to mine emerging and potential factors. Our research shows that continuously strengthening the digital construction of the elderly, promoting the digital literacy and skills cultivation of the elderly, and enhancing the sense of participation and happiness of the elderly can help improve the active digital aging of the elderly.
Whole-cell catalyze L-dopa to dopamine via co-expression of transport protein AroP in Escherichia coli
Authors: Gao Siyuan , Ma Ding , Wang Yongtao , Zhang Alei , Wang Xin , Chen Kequan 
Published: December 2022

Abstract
Dopamine is high-value compound of pharmaceutical interest, but its industrial scale production mostly focuses on chemical synthesis, possessing environment pollution. Bio-manufacturing has caused much attention for its environmental characteristic. Resting cells were employed to as biocatalysts with extraordinary advantages like offering stable surroundings, the inherent presence of expensive cofactors. In this study, whole-cell bioconversion was employed to convert dopa to dopamine. To increase the titer and yield of dopamine production through whole-cell catalysis, three kinds of aromatic amino acid transport protein, AroP, PheP and TyrP, were selected to co-expressed. The effects of the concentration of L-dopa, PLP, reaction temperature and pH were characterized for improvement of bioconversion. Under optimal conditions, dopamine titer reach to 1.44 g/L with molar yield of 46.3%, which is 6.62 times than that of initial conditions. The catalysis productivity of recombinant E. coli co-expressed DDC and AroP was further enhanced by repeated cell recycling, which maintained over 50% of its initial ability with eight consecutive catalyses. This study was the first to successfully bioconversion of dopamine by whole-cell catalysis and provided reference for whole-cell catalysis which is hindered by permeability.
Designed an Expert System for Diagnosis of Covid-19 Patients
Authors: Mishra Shashank , Aggarwal Mukul , Yadav Shivam , Sharma Yashika 
Published: December 2022

Abstract
The expert system solves problems within a specific area of the knowledge base. Prolog is a logical programming language which works on its knowledge base and effectively can be used to develop an expert system. Covid 19 is a pandemic deices and an expert system can be developed to diagnose this disease with the help of its symptoms that can be used as a knowledge base in Prolog. This expert system can make a fast diagnosis process for the covid 19 which is important to prevent the spread of the virus. Here we developed an expert system using prolog for the diagnosis purpose. Similar to humans, these systems can get better with time as they gain more experience. Expert systems combine their experiences and expertise into a knowledge base that is then used by an inference or rules engine, a set of rules that the software employs, to apply to certain scenarios. Prolog is ideal for use with intelligent systems for a number of reasons. Prolog can be viewed as a straightforward theorem prover or inference engine that derives from predefined rules. With the help of Prolog's built-in search and backtracking techniques, simple expert systems can be created.
DFT Study on Reaction Mechanism of Methanol Steam Reforming on MoS2(100)
Authors: Xu Lingjie , Huang Yanping , Yang Yunquan 
Published: December 2022

Abstract
As an excellent organic hydrogen energy storage medium with a high hydrocarbon ratio, methanol has a promising application prospect in on-board hydrogen production. Molybdenum-based catalysts, such as MoS2, have special electronic structure and exhibit catalytic performance similar to noble metals. At present, the reaction mechanism of methanol steam reforming (MSR) on the molybdenum sulfide is still unclear. In this work, DFT calculations were applied to examine the adsorption properties of the reactants, intermediates and products, to identify the transition state of reactions involved, and to explore the reaction mechanism of MSR on MoS2(100). It was found that the most probable path of carbon deposition is: CH3OH→CH2OH→CH2→CH→C. And the most probable path of methane formation is: CH3OH→CH3→CH4. The most advantageous reaction path is CH3OH→CH3O→ HCHO→CHO→HCOOH→COOH→CO2.
Source of Liquid Biopsy Biomarker: Exosome vs Whole Plasma, Fasting vs Non-fasting
Authors: Nasu Masaki , Khadka Vedbar , Jijiwa Mayumi , Kobayashi Ken , Deng Youping 
Published: December 2022

Abstract
Background
The liquid biopsy using plasma samples is being studied to find biomarkers for clinical applications. Exosomes encompass nucleic acids and metabolites that have been highlighted as a potential biomarker source. To test the efficacy of exosomes over plasma, we compared the profiles of small non-coding RNAs (ncRNAs) and metabolites extracted from exosomes (which were purified from plasma) to the profiles extracted directly from whole plasma. The fasting and non-fasting status of the samples were also compared.
Results
We found that ncRNA profiles were not affected by fasting for both exosomal and plasma samples. Our results showed that ncRNAs extracted from exosomes were found to have the more consistent profiles between fasting and non-fasting samples. The whole plasma RNA profiles contained high concentrations of cell-derived miRNAs that were likely based on hemolysis. We also found that some metabolites in whole plasma showed significant changes in concentration due to fasting status, whereas others did not.
Conclusions
Here, we propose that 1) fasting isn’t necessary for liquid biopsy study for both circulating ncRNA and metabolomic profiling as long as metabolites which aren’t affected by fasting status are chosen. 2) Exosomal RNAs must be used to obtain consistent results without batch effects in plasma samples due to different levels of hemolysis.
Polyunsaturated Fatty Acids Promote Protumoral Macrophage Polarization via a RhoA-YAP1 Signaling Pathway in the Ovarian Cancer Microenvironment
Authors: Chan David , WANG Huogang , Yung Mingo , Xuan Yang , Chen Fushun , Chan Wai-Sun , Siu Michelle , LONG Runying , LIANG Yonghao , Xu Dakang , Tsui Stephen , Ngan Hextan , Chan Karen 
Published: December 2022

Abstract
Tumor-associated macrophages (TAMs) are crucially associated with tumor development and progression; however, it remains unclear how the tumor microenvironment (TME) rewires the metabolic circuits and preferentially induces TAMs to polarize toward a protumoral phenotype. Here, we report that polyunsaturated fatty acids (PUFAs) in malignant ascites promote protumoral M2-like TAMs deposition and facilitate peritoneal metastases of epithelial ovarian cancer (EOC). We demonstrated that PUFAs in the lipid-enriched malignant ascites inactivate RhoA, reducing nuclear YAP1 in macrophages and promoting protumoral M2-like TAMs polarization with OXPHOS metabolism. Conditional Yap1 depletion in murine MΦs leads to skew macrophage polarization toward protumoral M2-like TAMs that, in turn, suppress CD8+ T cell infiltration and aggravate tumor colonization in vivo. Noticeably, the significance of nuclear YAP1 depletion was evinced in the infiltrating TAMs in tumor spheroids of malignant ascites from EOC patients. In contrast, restored nuclear YAP1 expression in TAMs by pharmacological suppression of MST1/2 enhances tumoricidal M1-like TAMs population and CD8+ T cells infiltration, restricting EOC peritoneal metastasis. These results indicate that PUFAs are a key player in promoting tumor-infiltrated TAMs polarization that, in turn, facilitates EOC tumor growth and metastasis.
The role and power of visual trigger on the experience of Autonomous Sensory Meridian Response (ASMR)
Authors: Maeno Ami , Kajimura Shogo 
Published: December 2022

Abstract
Despite the growing research interest in the autonomous sensory meridian response (ASMR), research on the triggers that induce ASMR has been scarce. In particular, the role of visual triggers in ASMR induction remains largely unknown. The current study, using the newly developed stimulus set, showed that the enhancement of auditory-induced ASMR by simultaneously presented visual triggers is due to information about the source of auditory triggers and that ASMR can be induced by visual triggers alone. In Experiment 1, we assessed whether the congruency of auditory and visual triggers affected the experience of ASMR and found that the occurrence of ASMR was significantly more frequent in the condition in which these triggers were congruent than when they were incongruent. In Experiment 2, we assessed whether the visual trigger was capable of inducing ASMR by itself and found that, although the frequency of ASMR occurrence was lower in the visual trigger than the auditory trigger only, the visual trigger was single-handedly able to induce ASMR. The generalization of these findings is provided by the sufficient number of newly prepared stimuli that successfully induced ASMR within a short duration. These results may facilitate psychophysiological research on the properties of ASMR-inducing stimuli.
Association of Deepression and Anxiety With Uncontrolled Hypertension: a Cross-sectional Study in Southwest Nigeria
Authors: Amaike Chikwendu , Salami Omotayo Felicia , Bamidele Olabisi Titilayo , Ojo Abayomi Moses , Otaigbe Idemudia , Abiodun Olumide , Olumide Adesola , Adebiyi Akindele Olupelumi 
Published: December 2022

Abstract
Background
Hypertension is a medical condition of public health concern that increases the risk for chronic non-communicable diseases and mortalities. In recent years, understanding its co-existence with other comorbidities have been the focus of better management. However, the relationship between hypertension and depression or anxiety has been contentious with diverse findings reported by different studies. Understanding the relationship between depressive and anxiety disorders and hypertension control will be crucial for reducing the mortality associated with hypertension. Therefore, this study was conducted to determine the association between depression or anxiety and hypertension control.
Methods
A cross-sectional study was conducted among 321 hypertensive patients accessing care in two hospitals. Depression and anxiety symptoms were assessed using the Hospital Anxiety and Depression Scale. Relationship between uncontrolled hypertension and depression or anxiety was assessed using binary logistics regression.
Results
The prevalence of depression and anxiety was 12.1% and 23.1% respectively. Total of 60 and 261 of the participants had controlled and uncontrolled blood pressure respectively. Out of the 261 participants with uncontrolled blood pressure, 14.2% and 23.4% had depression and anxiety respectively. Depression (OR=7.751, 95% CI=1.79-43.4, P=0.011) was associated with an increased risk for uncontrolled blood pressure after adjusting for sex, smoking of cigarette, age, marital status, and exercise.
Conclusion
There is a statistically significant relationship between depression and uncontrolled blood pressure. It is therefore relevant for healthcare providers to assess for depression in patients with hypertension and provide treatment to achieve hypertension control.
Different impacts of TP53 mutations on cell cycle-related gene expression among cancer types
Authors: Sasaki Keiju , Takahashi Shin , Ouchi Kota , Otsuki Yasufumi , Wakayama Shonosuke , Ishioka Chikashi 
Published: December 2022

Abstract
Functional properties caused by TP53 mutations are involved in cancer development and progression. Although most of the mutations lose normal p53 functions, some of them, gain-of-function (GOF) mutations, exhibiting novel oncogenic functions. No reports have analyzed the impact of TP53 mutations on the gene expression profile of the p53 signaling pathway across cancer types. This study is a cross-cancer type analysis of the effects of TP53 mutations on gene expression. A hierarchical cluster analysis of the expression profile of the p53 signaling pathway classified 21 cancer types into two clusters (A1 and A2). Changes in the expression of cell cycle-related genes and MKI67 by TP53 mutations were greater in cluster A1 than in cluster A2. There was no distinct difference in the effects between GOF and non-GOF mutations on the gene expression profile of the p53 signaling pathway.
Regional variations and sex-related differences in human tracheal ligaments
Authors: Fukushige Kaori , Okubo Tomohito , Shan Xiyao , Takeuchi Takao , Misaki Noriyuki , Naito Munekazu 
Published: December 2022

AbstractThis study aimed to investigate the characteristics of the ligaments present between the thyroid, cricoid, and tracheal cartilages on living human bodies and cadavers using a digital palpation device. The mean dynamic stiffness values of the cricothyroid ligaments were 622.0 ± 88.2 N/m (mean ± SD) for humans, 956.1 ± 75.0 N/m when measured directly in the cadavers, and 826.5 ± 105.7 N/m when removed from the cadavers. There was no significant difference in dynamic stiffness between the cricothyroid and the first annular ligaments. The dynamic stiffness of annular ligaments measured in the superior trachea of human subjects and cadavers decreased gradually toward the distal trachea, whereas the mechanical stress relaxation time increased distally. There was no difference in dynamic stiffness between males and females in the upper part of the trachea; however, the dynamic stiffness of the middle and inferior parts was significantly higher in females than in males. Furthermore, males, but not females, showed significant differences in dynamic stiffness between the superior and middle parts. These results reveal that there are regional and sex-related differences in tracheal ligaments. This information might prove useful for surgical airway management and so on.
Radiomics prediction of the pathological grade of bladder cancer based on multi-phase CT images
Authors: Jing Qian , Yang Ling , Hu Su , Gu Siqian , Yao Feirong , Hu Chunhong , Yao Tianyang , Dai Sunxian , Shen Ying 
Published: December 2022

Abstract
Background
The pathological grade of bladder cancer(BCa)is a critical determinant for the follow-up clinical decision and treatment of patients. The authors investigated a radiomic-clinical model in predicting the pathological grade of BCa.
Objective
This study explored the feasibility of the radiomics based on multi-phase thick-slice CT images combined with clinical risk factors in predicting of the pathological grade of BCa.
Methods
Patients with BCa who underwent CT scan and surgical treatment from January 2019 to December 2021 were analyzed retrospectively, with 104 cases of high-grade BCa and 100 cases of low-grade BCa included. Radiomics features were extracted from tumor volume in the images of the plain scan, corticomedullary phase, and parenchymal phase, respectively. Logistic Regression model, SVM model, and Random Forest model were established, and the model with higher diagnostic efficiency was chosen. Additionally, a radiomics-clinical model was conducted by selected independent predictors according to logistic regression analysis. Then the performance of the model was assessed.
Results
Among the 204 patients enrolled, the training cohort was consisted of 142 patients and the validation cohort was made up of 62 patients. The Logistic Regression model proved to be the most effective one among the three models. The radiomics-clinical model consisted of 2 independent predictors, patient age and Rad-Score, with an AUC of 0.904(95%CI 0.857–0.951) and 0.906༈95%CI 0.837–0.975༉in the training and validation cohorts, respectively. The diagnostic accuracy, sensitivity, and specificity of the validation cohort were 0.790, 0.813, and 0.767 respectively.
Conclusion
The radiomics-clinical model possesses great potential in predicting the pathological grade of BCa.
The bleaching effect of office bleaching agents containing S-PRG filler
Authors: Akabane Kodai , Hiraishi Noriko , Shimojima Mika , Nassar Mohannad , QI Feng , Otsuki Masayuki , Shimada Yasushi 
Published: December 2022

Abstract

Objectives:Surface reaction-type pre-reacted glass-ionomer (S-PRG) filler releases six types of ions with a neutralizing ability. This study evaluated the effect of S-PRG filler incorporation in an H2O2-based bleaching material on the bleaching efficacy, pH, and reaction state.Materials and Methods:The experimental bleaching material was formulated by the addition of 5% or 10% S-PRG fillers to the powder part. The stained bovine teeth were treated with the prepared bleaching paste. Commission internationale de l'éclairage (CIE) L*a*b* color space values were recorded before and after bleaching, and the color difference (ΔE) was calculated. Moreover, the used bleaching formulations were assessed for their pH values and reaction state by evaluating the oxidation state of manganese (Mn+2) using electron spin resonance (ESR).Results:Bleaching efficacy was increased by addition of S-PRG filles; no significant difference was observed between groups containing 5% and 10% S-PRG fillers. A significant increase in pH in S-PRG filler groups (5% pH 6.7, 10% pH 6.8) was found compared to the 0 % group (pH 4.8). ESR measurements showed that the signal emitted from Mn+2decreased over time. The S-PRG filler groups showed a significantly higher reduction in Mn+2compared to the 0% group, with no significant difference between the 5% and 10% S-PRG groups.Conclusions:S-PRG filler addition resulted in improved bleaching efficacy, higher reaction rate, and pH values that are close to neutral.Clinical Relevance:The effect of S-PRG filler addition may be effective on bleaching of H2O2-based martials.
The association between intimate partner violence and cervical cancer screening among women of childbearing age: A South African Case Study
Authors: Hollington Marcus 
Published: December 2022

Abstract

Background
In South Africa, cervical cancer is the second most prevalent cancer. Amidst the disease’s prevalence is the presence of Intimate Partner Violence in South Africa, which could impair the ability of women to undergo cervical cancer screening. Thus, illustrating its negative implications on health-seeking behavior. This study examined if, and how intimate partner violence among women aged between 15 and 49 years is associated with cervical cancer screening.
Methods
The study used cross-sectional data from the South Africa Demographic and Health Survey conducted in 2016. The population of interest was women aged between 15 and 49 years that underwent cervical cancer screening. Bivariate analysis was conducted to investigate the relationship between cervical cancer screening and each of the study’s independent variables. Finally, a binary regression model was used to determine the association between intimate partner violence and cervical cancer screening among women aged between 15 and 49 years, whilst controlling for other variables.
Results
The study found that 39% of women aged between 15 and 49 years underwent cervical cancer screening in South Africa at least once in their lifetime. Women that experienced intimate partner violence were more likely to undergo cervical cancer screening compared to women that did not experience intimate partner violence (UOR: 1.33; p < 0.05; CI: 1.07–1.65 and AOR: 1.46; p < 0.05; CI: 1.14–1.86). Area of residence, age, educational attainment, province, wealth quantile, ethnicity, number of sex partners, frequency of cigarette smoking, contraception, and health insurance were also found to be statistically associated with cervical cancer screening.
Conclusion
The study contributed to our understanding of predictors of cervical cancer screening in South Africa, particularly the association between intimate partner violence and cervical cancer screening. It found that women who experience intimate partner violence are more likely to undergo cervical cancer screening compared to women that do not experience intimate partner violence. This is because women who experience intimate partner violence are at greater risk of contracting cervical cancer. Thus, their need to undergo cervical cancer screening. This highlights the severity of intimate partner violence in South Africa and the health risks it poses to women, particularly regarding cervical cancer.