bluuebunny/crossref_metadata_2025_split huggingface dataset:
Human umbilical cord mesenchymal stem cell treatment alleviates symptoms in an atopic dermatitis-like mouse model
Authors: Hua Chunting , Liang Qichang , Chen Siji , Zhu Jiang , Tang Yi , Chen Xianzhen , Song Yinjing , van der Veen Stijn , Cheng Hao 
Published: May 2023

Abstract
Background
Atopic dermatitis (AD) is one of the most common immune and inflammatory skin disorders, leading to insufferable itching and skin abnormalities that seriously affect life quality of patients. There are still huge unmet needs for long-term and effective disease control, despite currently available therapies. Evidenced by some preclinical and clinical studies of AD treatment with stem cells, stem cell treatment could significantly and effectively ameliorate AD symptoms.

Objectives
To elucidate underlying mechanisms of how stem cells therapy alleviates AD-like symptoms.

Methods
An AD-like mouse model was constructed and treated with mesenchymal stem cells (MSCs) subcutaneously or subcutaneously combined with intravenously. The differentially expressed genes were sorted out from RNA sequencing results of dorsal skin and blood.

Results
Two injection routes of MSCs could alleviate AD-like symptoms and pathologic changes of the skin and immune organs. RNA sequencing of dorsal skin sections and blood provided gene expression signatures for amelioration of skin defects, inflammatory and immune modulation by MSCs, as well as common AD molecular markers for the skin and blood, which may benefit for clinical diagnosis. IL-1β and its signaling pathway were specifically found to be associated with the development of AD-like dermatitis lesions. MSC treatment effectively inhibited the JAK-STAT pathway and receptors of IL-4, IL-13, IL-17, and IgE.

Conclusions
MSC therapy could regulate abnormal immune and inflammatory status in AD. Mechanistic exploration will contribute to the development of personalized AD treatment based on MSCs.
Multiple sampling schemes and deep learning improve active learning performance in drug-drug interaction information retrieval analysis from the literature
Authors: Xie Weixin , Fan Kunjie , Zhang Shijun , Li Lang 
Published: May 2023

Abstract
Background
Drug-drug interaction (DDI) information retrieval (IR) is an important natural language process (NLP) task from the PubMed literature. For the first time, active learning (AL) is studied in DDI IR analysis. DDI IR analysis from PubMed abstracts faces the challenges of relatively small positive DDI samples among overwhelmingly large negative samples. Random negative sampling and positive sampling are purposely designed to improve the efficiency of AL analysis. The consistency of random negative sampling and positive sampling is shown in the paper.

Results
PubMed abstracts are divided into two pools. Screened pool contains all abstracts that pass the DDI keywords query in PubMed, while unscreened pool includes all the other abstracts. At a prespecified recall rate of 0.95, DDI IR analysis precision is evaluated and compared. In screened pool IR analysis using supporting vector machine (SVM), similarity sampling plus uncertainty sampling improves the precision over uncertainty sampling, from 0.89 to 0.92 respectively. In the unscreened pool IR analysis, the integrated random negative sampling, positive sampling, and similarity sampling improve the precision over uncertainty sampling along, from 0.72 to 0.81 respectively. When we change the SVM to a deep learning method, all sampling schemes consistently improve DDI AL analysis in both screened pool and unscreened pool. Deep learning has significant improvement of precision over SVM, 0.96 vs. 0.92 in screened pool, and 0.90 vs. 0.81 in the unscreened pool, respectively.

Conclusions
By integrating various sampling schemes and deep learning algorithms into AL, the DDI IR analysis from literature is significantly improved. The random negative sampling and positive sampling are highly effective methods in improving AL analysis where the positive and negative samples are extremely imbalanced.
Improving value for underserved populations with a community-based intervention: a retrospective cohort study
Authors: Pinnock Claude , Rothen John , Carlough Tom , Shah Nirav R. 
Published: May 2023

Abstract
Background
Healthcare inequity drives high costs, worse outcomes and is heavily influenced by social determinants of health (SDOH). Addressing health behaviors and SDOH through a culturally competent community-based exposure may be effective in improving value for Medicaid enrollees. This study aims to evaluate whether such an exposure lowers costs at equal or improved quality.

Methods
A retrospective cohort study leveraging claims data was conducted in Detroit, Michigan from April 2021 to April 2022 to examine the impact of a community-based peer support program on clinical, utilization and financial outcomes. A one-to-one propensity matching of 738 pairs of African American Medicaid enrollees was generated, and compared the difference of differences between inpatient, emergency department, prescription and outpatient paid amounts, utilization, and available claims-based quality metrics.

Results
Compared to controls, peer support recipients generated significantly lower per member per month costs ($115, (95% CI $20.2 to $210)). Recipients showed a significant increase in the Adult Access to Preventative/Ambulatory Health Services 20–44 year old quality metric (8.31% (95% CI 0.35–16.3%)). Member retention in the health insurance plan was significantly higher for peer support recipients vs. the control group by 3.62% (p < 0.05). Peer support recipients displayed non-significant improvement on all other utilization and actuarial measures. No significant difference was found for any of the other examined quality metrics.

Conclusions
Among a population of African American Medicaid enrollees, a culturally competent community-based intervention was associated with lower cost and better member retention with preserved or improved quality.
Effects of fearful face presentation time and observer’s eye movement on the gaze cue effect
Authors: Yu Chuntai , Ishibashi Keita , Iwanaga Koichi 
Published: May 2023

Abstract
Background
There are many conflicting findings on the gaze cueing effect (GCE) of emotional facial expressions. This study aimed to investigate whether an averted gaze, accompanied by a fearful expression of different durations, could enhance attentional orientation, as measured by a participant’s eye movements.

Methods
Twelve participants (3 females) completed the gaze cue task, reacting to a target location after observing changes in the gaze and expression of a face illustrated on a computer screen. Meanwhile, participants’ eye movements were monitored by electrooculography. The GCE was calculated by reaction time as an indicator of attention shift.

Results
The analysis of the overall data did not find a significant effect of fearful facial expressions on the GCE. However, analysis of trial data that excluded a participant’s eye movement data showed that brief (0, 100 ms) presentation of the fearful facial expression enhanced the GCE compared to that during a neutral facial expression, although when the presentation time of the fearful expression was increased to 200 or 400 ms, the GCE of the fearful expression was at the same level as when model showed a neutral expression.

Conclusions
The results suggest that the attention-enhancing effect of gaze cues induced by rapidly presented fearful expressions occurs only when the effect of eye movement trials is excluded. This effect may be mediated by reflexively neural circuits in the amygdala that process threatening stimuli. However, as the expression duration increased, the fearful expression’s attention-enhancing effect decreased. We suggest that future studies on the emotion modulation of GCE should consider the negative effects of participants’ saccades and blinks on the experimental results.
Trade-offs in telemetry tag programming for deep-diving cetaceans: data longevity, resolution, and continuity
Authors: Cioffi William R. , Quick Nicola J. , Swaim Zachary T. , Foley Heather J. , Waples Danielle M. , Webster Daniel L. , Baird Robin W. , Southall Brandon L. , Nowacek Douglas P. , Read Andrew J. 
Published: May 2023

Abstract
Background
Animal-borne telemetry instruments (tags) have greatly advanced our understanding of species that are challenging to observe. Recently, non-recoverable instruments attached to cetaceans have increased in use, but these devices have limitations in data transmission bandwidth. We analyze trade-offs in the longevity, resolution, and continuity of data records from non-recoverable satellite-linked tags on deep-diving Ziphius cavirostris in the context of a behavioral response study of acute noise exposure. We present one data collection programming scheme that balances resolution and continuity against longevity to address specific questions about the behavioral responses of animals to noise exposure in experimental contexts. We compare outputs between two programming regimes on a commercially available satellite-linked tag: (1) dive behavior summary defined by conductivity thresholds and (2) depth time-series at various temporal resolutions.

Results
We found that time-series data vary from the more precisely defined dives from a dive summary record data stream by an acceptable error range for our application. We determined a 5-min time-series data stream collected for 14 days balanced resolution with longevity, achieving complete or nearly complete diving records in 6 out of 8 deployments. We increased our data message reception rate several fold by employing a boat based data capture system. Finally, a tag deployed in a group concurrently with a high-resolution depth recorder showed high depth concordance.

Conclusions
We present the conceptual framework and iterative process for matching telemetry tag programming to research questions that we used and which should be applicable to a wide range of studies. Although designing new hardware for our specific questions was not feasible at the time, we were able to optimize the sampling regime of a commercially available instrument to meet the needs of our research questions and proposed analyses. Nevertheless, for other study species or designs, the complicated intersection between animal behavior and bandwidth of telemetry systems can often create a severe mismatch among research questions, data collection, and analysis tools. More flexible programming and purpose-built instruments will increase the efficacy of these studies and increase the scientific yield relative to the inherently higher risk of invasive studies.
Salvage transoral laser microsurgery for early local recurrence of glottic squamous cell cancer
Authors: Cai Zhimou , Yue Huijun , Chen Lin , Xv Yang , Li Yun , Tang Bingjie , Lin Yu , Lei Wenbin 
Published: May 2023

Background For recurrent laryngeal cancer, the feasibility of salvage transoral laser microsurgery (TLM) remains controversial. This study compared the efficacy of TLM and open partial laryngectomy (OPL) for treatment of early local recurrence of glottic squamous cell cancer (GSCC) and confirm the effectiveness of salvage TLM as a treatment option. Methods This retrospective study involved 55 patients with early local recurrent GSCC treated with TLM, and the oncologic outcomes, functional outcomes, hospitalization time and complications were compared with a group of 40 recurrent GSCC patients matched for clinical variables of TLM group, treated by OPL by the same team of surgeons. Results The 5-year overall survival and disease-specific survival rates were 65.8% and 91.5%, respectively, for 55 patients with rTis–rT2 stage treated by TLM and 77.1% and 94.7%, respectively, for 40 patients with rTis–rT2 stage treated by OPL (OPL group). In the TLM and OPL groups, the local control rates after 5 years were 77.5% and 79.3%, respectively, and the laryngeal preservation rates were 94.4% and 83.6%, respectively ( p > 0.05). Compared with the OPL group, the complication rate (1.82%) and hospitalization duration (5.42 ± 2.26 days) were significantly lower in the TLM group ( p < 0.05). Compared with the OPL group, postsurgical health-related quality of life and quality of voice were significantly better in the TLM group ( p < 0.001). Conclusion Salvage TLM can be used as an effective treatment option for suitable patients after a full, comprehensive, and careful assessment of the characteristics of early locally recurrent glottic carcinoma. Graphical Abstract
The logic between nature and culture: food in the wedding traditions across East Asia
Authors: Han Min 
Published: May 2023

AbstractBased on the author’s fieldwork in China and Japan, literature research and the study of specimen materials and video data on weddings of ROK, Japan and China, which are collected by the Japan National Museum of Ethnology (or Minpaku), this paper attempts to explore the cultural symbolic significance that humans bestow on food, and to further reveal the cultural diversity in East Asia and the common structure of human mind by comparing the flow of food and the ways and scopes in which the wedding foods are consumed in East Asia.In East Asia wedding customs, expectations through food for the bride’s fertility and her belonging to her husband’s patrilineal family are very common. However, the food and eating behaviors that express expectations for the groom are rare, only slightly visible in the dry bonito at the time of engagement in Japan and the 12 bowls of rice that the groom will eat on the day of the Yao wedding in China. Dried bonito signifies virility and victory of men, reflecting the features of Japanese maritime culture and the influence of samurai culture in history.East Asian wedding rituals are diverse in form, but the commonality among them can also be seen, that is, human beings find cultural meanings in different natural environments that correspond to human society, and then internalize the natural attributes through homophonic pun, imitation and other ways. Food is used in weddings to express people’s best wishes for the happiness of the newlyweds’ families, to have descendants and longevity of their marriage.
Adherence to Gender Affirming Hormone Therapy in Transgender Adolescents and Adults: A Retrospective Cohort Study
Authors: Gupta Pranav , Patterson Briana C , Chu Lena , Gold Sarah , Amos Seth , Yeung Howa , Goodman Michael , Tangpricha Vin 
Published: May 2023

AbstractContextTransgender and gender diverse (TGD) individuals often seek gender-affirming hormone therapy (GAHT). While receipt of GAHT has been associated with improved well-being, the risk of GAHT discontinuation and its reasons are not well known.ObjectiveThere were two main objectives: (1) To investigate the proportion of TGD individuals who discontinue therapy after an average of 4 years (maximum 19 years) since GAHT initiation; and (2) to explore reasons for GAHT discontinuation. This was a retrospective cohort study at academic centers providing care to TGD adolescents and adults. TGD individuals prescribed estradiol or testosterone between January 1, 2000, and January 1, 2019, were included. GAHT continuation was ascertained using a 2-phase process. In phase 1, Kaplan–Meier survival analyses were used to examine likelihood of GAHT discontinuation and compare discontinuation rates by age and sex assigned at birth. In phase 2, reasons for stopping GAHT were investigated by reviewing records and by contacting study participants who discontinued therapy. The main outcome measures were incidence and determinants of GAHT discontinuation.ResultsAmong 385 eligible participants, 231 (60%) were assigned male at birth and 154 (40%) were assigned female at birth. Less than one-third of participants (n = 121) initiated GAHT prior to their 18th birthday, constituting the pediatric cohort (mean age 15 years), and the remaining 264 were included in the adult cohort (mean age 32 years). In phase 1, 6 participants (1.6%) discontinued GAHT during follow-up, and of those only 2 discontinued GAHT permanently (phase 2).ConclusionGAHT discontinuation is uncommon when therapy follows Endocrine Society guidelines. Future research should include prospective studies with long-term follow-up of individuals receiving GAHT.
Οι ρόλοι, οι αρμοδιότητες και η επαγγελματική ταυτότητα του υποδιευθυντή δευτεροβάθμιας εκπαίδευσης
Authors: Λαζαρίδου Αγγελική , Γκορίλα Αικατερίνη 
Published: May 2023

Στo άρθρο αυτό παρουσιάζονται τα αποτελέσματα ποιοτικής έρευνας σχετικά με τη συμβολή του ρόλου του Υποδιευθυντή στη διοίκηση της σχολικής μονάδας στο σύγχρονο Ελληνικό Γυμνάσιο και Γενικό Λύκειο, υπό το πρίσμα των αρμοδιοτήτων που του αποδίδονται από τον νόμο και των επιπλέον που τελικά αναλαμβάνει. Η έρευνα έδωσε τη δυνατότητα να ακουστεί η φωνή της υποδιεύθυνσης και να αποκαλυφτεί ο πλούτος των εμπειριών και των προκλήσεων των υποδιευθυντών. Τα πολλά και σημαντικά καθήκοντα και οι διευρυμένες αρμοδιότητες στα σχολικά δρώμενα, καθιστούν τον Υποδιευθυντή σημαντικό παράγοντα της αποτελεσματικής διοίκησης μιας σχολικής μονάδας. Ο ρόλος του δεν είναι απλά γραφειοκρατικός και διεκπεραιωτικός, αλλά ηγετικός, όταν με την ανάληψη πρωτοβουλιών, μπορεί να στηρίξει ουσιαστικά την ηγεσία ενός σχολείου. Μέσα από την έρευνα, σκιαγραφείται, επίσης, η επαγγελματική ταυτότητα του Υποδιευθυντή, χωρίς ανάλογο στην ελληνική βιβλιογραφία, αφενός μέσα από τα χαρακτηριστικά της προσωπικότητάς του αλλά και του τρόπου µε τον οποίο οι υποδιευθυντές νοηματοδοτούν το ρόλο τους, και αφετέρου μέσα από τους παράγοντες οι οποίοι επηρεάζουν την άσκηση του διοικητικού του έργου. Η έρευνα προχωράει σε ερμηνείες με όρους αυτοπροσδιορισμού σε σχέση με τα παραπάνω στοιχεία και αναδεικνύει τέσσερις όψεις της επαγγελματικής ταυτότητας του Υποδιευθυντή: α) το διοικητικό στέλεχος β) ο παιδαγωγός γ) ο ειδικός στις ανθρώπινες σχέσεις και δ) ο εκκολαπτόμενος ηγέτης. Κατανοώντας τους ιδιαίτερους όρους συγκρότησης της κάθε επαγγελματικής ταυτότητας, διαπιστώνουμε ότι ο Υποδιευθυντής είναι βασικό διοικητικό στέλεχος της εκπαίδευσης, με ιδιαίτερες δεξιότητες και επιτελικά χαρακτηριστικά κι επομένως η ανάδειξη της σπουδαιότητας του ρόλου του είναι επιβεβλημένη.
Η εξέταση του ρόλου των οικογενειακών εμπειριών στην ανταπόκριση των παιδιών σε δραστηριότητες αναδυόμενου γραμματισμού στον παιδικό σταθμό : διερεύνηση των απόψεων παιδαγωγών και γονέων
Authors: Τσιόπελα Παρασκευή , Τζακώστα Μαρίνα , Σπαντιδάκης Ιωάννης 
Published: May 2023

Σκοπός της μικτής αυτής έρευνας είναι να διερευνήσει τις απόψεις παιδαγωγών και γονέων σχετικά με τον ρόλο που έχουν οι οικογενειακές εμπειρίες γραμματισμού παιδιών ηλικίας 3-4,5 ετών στην ανταπόκρισή τους σε δραστηριότητες αναδυόμενου γραμματισμού στον παιδικό σταθμό. Για την υλοποίηση της έρευνας κατασκευάστηκαν και χρησιμοποιήθηκαν δύο ερευνητικά εργαλεία : ένας οδηγός ημιδομημένης συνέντευξης, που εξετάζει τις σχετικές με τον αναδυόμενο γραμματισμό αντιλήψεις και πρακτικές των παιδαγωγών, αξιολογώντας παράλληλα την αποτελεσματικότητα των δραστηριοτήτων που εφαρμόζονται στο οικογενειακό περιβάλλον, και ένα ερωτηματολόγιο που εξετάζει τις αντίστοιχες αντιλήψεις και πρακτικές που εφαρμόζουν οι γονείς στο πλαίσιο της οικογενειακής ζωής. Στο ποιοτικό σκέλος της έρευνας συμμετείχαν 12 παιδαγωγοί στις τάξεις των οποίων φοιτούν τα παιδιά των 149 γονέων που συμπλήρωσαν ερωτηματολόγιο το οποίο έγινε αντικείμενο ποσοτικής επεξεργασίας. Τα ευρήματα έδειξαν ότι : α) υλοποιούνται δραστηριότητες αναδυόμενου γραμματισμού στο οικογενειακό περιβάλλον και τον παιδικό σταθμό αλλά ενισχύεται κυρίως ο προφορικός λόγος και η αναδυόμενη ανάγνωση, β) υπάρχει μια στατιστικά σημαντική σχέση ανάμεσα στο μορφωτικό επίπεδο των γονέων και τις πρακτικές γραμματισμού που χρησιμοποιούν. Τα αποτελέσματα από τη συνδυαστική διερεύνηση των δύο πεδίων είναι ενθαρρυντικά, αλλά κρίνεται χρήσιμη η πραγματοποίηση συνεντεύξεων με γονείς για την περαιτέρω διερεύνηση των οικογενειακών πρακτικών.
Κινούμενα σχέδια και οπτικές αναπαραστάσεις του φύλου: Διδακτική πρόταση κριτικού γραμματισμού για παιδιά πρωτοσχολικής ηλικίας
Authors: Γκαλά Γαλήνη , Γεωργάλου Μαρίζα 
Published: May 2023

Η παρούσα εργασία διερευνά τις οπτικές αναπαραστάσεις του φύλου στις δημοφιλείς παιδικές σειρές κινουμένων σχεδίων Πέππα το Γουρουνάκι και Bluey που μεταδίδονται από την τηλεόραση και το διαδίκτυο και απευθύνονται σε παιδιά προσχολικής και πρωτοσχολικής ηλικίας. Αναλύονται δύο επιλεγμένα επεισόδια, ένα από την κάθε σειρά, με τα μεθοδολογικά εργαλεία της Γραμματικής του Οπτικού Σχεδίου (Grammar of Visual Design: Kress & van Leeuwen, 2006). Από την ανάλυση προκύπτει ότι τo οπτικό κείμενο της Πέππα το Γουρουνάκι εγγράφει μεγαλύτερο σεξιστικό αποτύπωμα στη συνείδηση παιδιών προσχολικής και πρωτοσχολικής ηλικίας, σχετικά με τις έμφυλες διαφορές, σε σύγκριση με το οπτικό κείμενο της Bluey, στο οποίο αναπαράγεται οπτικά η έμφυλη ανισότητα, αλλά παράλληλα εντάσσονται ενθαρρυντικά μη στερεότυπα στοιχεία σε αυτό. Με βάση την ανάλυσή μας, και με θεωρητικό υπόβαθρο τον κριτικό γραμματισμό και το μοντέλο των πολυγραμματισμών, προτείνουμε δραστηριότητες για παιδιά πρωτοσχολικής ηλικίας, με στόχο την αποδυνάμωση και τη μετατόπιση της ιδεολογίας που αφορά το φύλο σε σχέση με την εξωτερική εμφάνιση, τα χρώματα και τα παιχνίδια ρόλων.
Factors associated with asthma and allergies in prehospital practitioners
Authors: Möckel Luis , Arnold Christina , May Tobias , Maaß Leona , Hofmann Thomas , Möckel Christina 
Published: May 2023

Aim:This analysis was carried out to identify factors associated with asthma and allergies in prehospital emergency medical services staff in Germany over a 12-month period.Methods:Multivariable logistic regression analysis was applied and adjusted odds ratios (AOR) with corresponding 95% confidence intervals (95% CI) were calculated.Results:In total, 2313 prehospital emergency medical services staff from Germany were included into the analysis. Women had the highest prevalence of asthma (12.28%) and allergies (40.61%). Asthma was significantly associated with gender, with lower odds for male (AOR 0.60; 95% CI [0.45-0.81]) than female practitioners. Allergies were significantly associated with: gender (male: AOR: 0.57; 95% CI (0.47-0.70)); smoking status (smokers: AOR: 0.79 (95% CI (0.62-0.99)); and role (trainees: AOR 1.37; 95% CI (1.06-1.78)).Conclusion:There is a high 12-month prevalence of asthma and allergies in certain groups of prehospital emergency practitioners in Germany and this is associated with several factors.
biblioteques universitàries a Catalunya (2020-2022): pandèmia, Disrupció i transformació digital
Authors: Merino Àngels 
Published: May 2023

El 14 de març de 2020 les biblioteques universitàries catalanes tancaven les seves seus presencials i passaven a oferir tots els recursos i serveis en línia. Aquesta disrupció sense precedents determina l'activitat de les deu biblioteques universitàries del sistema durant els tres anys que s’analitzen enaquest article i precipita una transformació digital que es traduirà en nous enfocaments i noves metodologies de treball que van mes enllà dels tres anys analitzats.
Tot i aquesta disrupció, les biblioteques van continuar desplegant els projectes i objectius planificats, entre els quals sobresurten, per la seva rellevància, en primer lloc, la implementació del nou sistema de gestió bibliotecària ALMA, que es va adjudicar a l’empresa Exlibris, al juliol del 2020 per a totes les biblioteques del Consorci de Serveis Universitaris de Catalunya (CSUC) i en segon lloc, totes les actuacions dutes a terme per les biblioteques per fixar la ciència oberta en les agendes universitàries i consegüentment posicionar-se com a agents estratègics de suport a la recerca a les seves institucions.Finalment, el període acaba amb una greu crisi energètica a escala mundial els efectes de la qual encara son incerts, però que s’albira que afectarà la gestió dels serveis bibliotecaris que, necessàriament, haurà de ser més sostenible i eficient.