bluuebunny/crossref_metadata_2025_split huggingface dataset:
Episode-specific change in hippocampal CA1 neurons: real-time temporal dynamics in multi-unit firings
Authors: Ishikawa Junko , Tomokage Takuto , Mitsushima Dai 
Published: May 2023

Abstract
Episodic memory contains “what-where-when” information of personal experience. There are innumerable episodes, but how the brain processes each episode remains unknown. We discovered episode-specific synchronized activities by multiple neurons in the hippocampal CA1, which were characterized by super burst, ripple-firing, and no-firing silent periods. Since CA1 neurons exhibited episode-specific and cell-dependent diversification of plasticity at excitatory/inhibitory synapses, super burst may be a trigger event for synaptic plasticity induction, contributing to episode encoding by ripple-firings. This study demonstrated the spatiotemporal coding of episodes by multiple-CA1 neurons and the synaptic mechanisms that underpin them. These findings revealed the existence of variety of episode-specific mechanisms of CA1 neurons; episode-specific super bursts that promote diversity at excitatory/inhibitory synapses could generate thousands of ripple-firings including past memory.
A narrative review of the neurological manifestations of human adenosine deaminase 2 deficiency
Authors: Mariia Dzhus , Ehlers Lisa , Wouters Marjon , Jansen Katrien , Schrijvers Rik , De Somer Lien , Vanderschueren Steven , Baggio Marco , Moens Leen , Verhaaren Benjamin , Lories Rik , Bucciol Giorgia , Meyts Isabelle 
Published: May 2023

Abstract
Deficiency of human adenosine deaminase type 2 (DADA2) is a complex systemic autoinflammatory disorder characterized by vasculopathy, immune dysregulation, and hematologic abnormalities. The most notable neurological manifestations of DADA2 are strokes that can manifest with various neurological symptoms and are potentially fatal. However, neurological presentations can be diverse. We here present a review of the neurological manifestations of DADA2 to increase clinical awareness of DADA2 as the underlying diagnosis. We reviewed all published cases of DADA2 from 1 January 2014 until 19 July 2022 found via PubMed. 129 articles describing the clinical features of DADA2 were included in the analysis. 628 patients diagnosed with DADA2 were included in the review. 50.3% of patients had at least signs of one reported neurological event, which was the initial or sole manifestation in 5.7% and 0,6%, respectively. 77.5% of patients with neurological manifestations had at least signs of one cerebrovascular accident, with lacunar strokes being the most common and 35.9% of them having multiple stroke episodes. There is a remarkable predilection for the brain stem and gray matter, with 37.3% and 41.6% of ischemic strokes, respectively. Other neurological involvement included neuropathies, focal neurological deficits, ophthalmological findings, convulsions, headaches. In summary, neurological manifestations affect a significant proportion of patients with DADA2, and the phenotype is broad. Neurological manifestations can be the first and single manifestation of DADA2. Therefore, stroke, encephalitis, posterior reversible encephalopathy syndrome, mono- and polyneuropathy, and Behçet's disease-like presentations should prompt the neurologist to exclude DADA2, especially but not only in childhood.
Development and validation of a nomogram for predicting overall survival of resected N2 non-small cell lung cancer patients undergoing neoadjuvant radiotherapy.
Authors: Shi Jiaxin , Peng Bo , Wang Chenghao , Zhou Xiang , Lu Tong , Xu Ran , Chang Xiaoyan , Shen Zhiping , Wang Kaiyu , Xu Chengyu , Zhang Linyou 
Published: May 2023

Abstract
Introduction Currently, the prognosis of resected N2 non-small cell lung cancer patients undergoing neoadjuvant radiotherapy is poor. The goal of this research was to develop and validate a novel nomogram for exactly predicting the overall survival (OS) of resected N2 NSCLC patients undergoing neoadjuvant radiotherapy.Methods The data applied in our research were downloaded from the Surveillance, Epidemiology, and End Results (SEER) database. We divided selected data into a training cohort and a validation cohort using R software, with a ratio of 7:3. Univariate Cox regression and multivariate Cox regression were utilized to select significant variables to build the nomogram. In order to validate our nomogram, calibration curves, receiver operating characteristic curves (ROC), decision curve analysis (DCA), and Kaplan-Meier survival curves were employed. The nomogram model was also compared with the tumor-node-metastasis (TNM) staging system by utilizing Net reclassification index (NRI) and Integrated Discrimination Improvement (IDI).Results Eight variables—age, sex, operative type, LN removed number, chemotherapy, AJCC stage, M stage, histology—were statistically significant in the multivariate Cox Regression Analysis and were selected to develop our nomogram. Based on ROC curves, calibration curves, and DCA analysis, our novel nomogram demonstrated good predictive accuracy and clinical utility. Using Kaplan-Meier (KM) survival curves and log-rank tests, the risk stratification system was able to stratify patients based on their estimated mortality risk. The nomogram performed better than the TNM staging system based on the NRI and IDI indexes.Conclusions We developed and validated a nomogram to predict prognosis of resected N2 NSCLC patients undergoing neoadjuvant radiotherapy. By using this nomogram, Clinicians may find this nomogram useful in predicting OS of targeted patients and making more appropriate treatment decisions.
Clinical Effect of the Internal Fixation for Rib Fracture with Single Utility Port Complete Video-Assisted Thoracoscopic Surgery
Authors: Wang Jindong , Sun Zhiguang , Liu Yongshuai , Gong Weiyong , Wang Jianxin , Deng Junyi , Fu Yue , Lan Jishan 
Published: May 2023

Abstract
Backgrounds: The internal fixation for rib fracture with a single utility port complete video-assisted thoracoscopic surgery (VATS)isa promising surgical approach for treating multiple rib fractures. The study aimed to investigate the minimally invasive surgical procedure’s clinical effect in treating multiple rib fractures．
Methods: Seventy-three patients with multiple rib fractures were divided into two groups according to surgical procedure. In the study group, 42 patients were operated on with the internal fixation of rib fracture with a single utility port complete VATS. In the control group, this study performed the open operative internal fixation for rib fracture with traditional thoracotomy on 31 patients. The surgical-related indexes were retrospectively analyzed. These included the operative time, the intraoperative blood loss, the drainage amount of the chest tube, the placement time of the chest tube, the postoperative hospital stay, the incidence of postoperative complications, the imaging efficacy of rib fixation of rib fractures, and visual analog scale of pain scoring (VAS scoring).
Results: There was no difference in the operative time between the study and control groups (P = 0.806). Theintraoperative blood loss, the chest tube drainage amount, the chest tube placement time, the postoperative hospital stay, and the incidence of postoperative complications in the study group were lower than those in the control group (P < 0.05). There was no significant difference in the imaging efficacy of rib fixation of rib fractures between the two groups (P = 0.806). VAS scores in the study group on the seventh postoperative day were significantly reduced compared with the control group (P= 0.026).
Conclusion: The internal fixation for rib fractures with single utility port complete VATS is a feasible, safe, simple, and minimally invasive surgical procedure to treat multiple rib fractures, which is worthy of clinical application.
Physicians' acceptance of drug-drug interaction alerts from clinical decision support systems: A systematic review and meta-analysis
Authors: Felisberto Mariano , Lima Geovana dos Santos , Celuppi Ianka Cristina , Fantonelli Miliane dos Santos , Zanotto Wagner Luiz , Oliveira Júlia Meller Dias , Mohr Eduarda Talita Bramorski , Santos Ranieri Alves , Scandolara Daniel Henrique , Cunha Célio Luiz , Hammes Jades Fernando , Rosa Júlia Salvan , Demarchi Izabel Galhardo , Wazlawick Raul Sidnei , Dalmarco Eduardo Monguilhott 
Published: May 2023

Abstract
Background
To reduce the risk of adverse drug events related to drug-drug interaction (DDI), healthcare systems worldwide are developing and implementing electronic health records with clinical decision support systems (CDSS). Primary studies have demonstrated that despite being useful, most of the alerts generated by these systems are ignored by prescribers. To provide more information about this issue, we conducted a systematic review and meta-analysis on the prevalence of DDI alerts generated by CDSS and alert overrides by physicians.
Materials and methods
The search strategy was implemented by applying the terms and MeSH headings and conducted in the MEDLINE/PubMed, EMBASE, Web of Science, Scopus, LILACS, and Google Scholar databases. Blinded reviewers screened 1873 records and 86 full studies, and 16 articles were included for analysis. Quality assessment was performed by JBI critical appraisal tools, and the meta-analysis was performed using the R software.
Results
The overall prevalence of alert generated by CDSS was 13% (CI95% 5–24%, p-value < 0.0001, I^2 = 100%), and the overall prevalence of alert override by physicians was 90% (CI95% 85–95%, p-value < 0.0001, I^2 = 100%). Only 2 of the 16 studies showed moderate or low methodological quality.
Discussion
This systematic review presents data obtained from primary studies showing a high rate of alert overrides, even after CDSS adjustments that significantly reduced the number of alerts. After analyzing the articles included in this review, it was clear that the CDSS alerts physicians about potential DDI should be developed with a focus on the user experience, thus increasing their confidence and satisfaction, which may increase patient clinical safety.
Carbon Negative Replacements of Gasoline and Diesel fuel
Authors: Tyurin Michael Vladislavovich 
Published: May 2023

Abstract
We offer new Gasoline replacements Carbon Negative fuel n-Butanol or fuel Isobutanol both alone or in combination with Diacetyl alcohol (the mixture 80 (vol/vol) fuel n-Butanol or fuel Isobutanol and 20% (vol/vol) DAA) for the States where the air temperature goes below 34oF. We offer the new Diesel fuel replacement Diacetyl alcohol (DAA). Explosive energy of DAA is much higher that that of Diesel fuel therefore we recommend our customers to check their engine combustion chamber gaskets with the dealerships mechanics on a regular basis. However we did not detect any damage of said gaskets ourselves during the 20,000 miles testing period. We offer the new type of gas stations selling not only Carbon Negative fuels but also distilled water and foods for home cooking to save time of valuable customers. Offer of Carbon Negative Gasoline replacement will help to the reduction of the air CO2 content which will shortly (10–25 years from now) cause the shortness of fresh water on Earth and the resulting from that Global Starvation.
Definition and validation of the nursing diagnosis label “wish to die”: A research protocol.
Authors: Monforte-Royo Cristina , Goni-Fuste Blanca , Crespo Iris , Pergolizzi Denise , Martin-Delgado Leandra , Pilar Fuster , Bellido-Perez Mercedes , Tomas-Sabado Joaquin , Rodriguez-Prat Andrea 
Published: May 2023

Abstract
Background: Euthanasia has been incorporated into the health services of seven countries. The legalisation of these practices has important repercussions for the competences of nurses, and it raises questions about their role. When a patient with advanced disease expresses a wish to die, what is expected of nurses? What are the needs of these patients, and what kind of care plan do they require? What level of autonomy might nurses have when caring for these patients? The degree of autonomy that nurses might or should have when it comes to addressing such a wish and caring for these patients has yet to be defined. Recognising the wish to die as a nursing diagnosis would be an important step towards ensuring that these patients receive adequate nursing care.
This study-protocol aims to define and validate the nursing diagnosis wish to diein patients with advanced disease, establishing its defining characteristics and related factors; to define nursing-specific interventions for this new diagnosis.
Methods: A prospective three-phase study will be carried out. Phase-A) Foundational knowledge: an overview of systematic reviews will be conducted; Phase-B) Definition and validation of the diagnostic nomenclature, defining characteristics and related factors by means of an expert panel, a Delphi study and application of Fehring’s diagnostic content validation model; Phase-C) Consensus validation of nursing-specific interventions for the new diagnosis. At least 200 academic and clinical nurses with expertise in the field of palliative care will be recruited as participants across the three phases.
Discussion: The definition of the wish to die as a nursing diagnosis would promote greater recognition and autonomy for nurses in the care of patients who express such a wish, providing an opportunity to alleviate underlying suffering through nursing-specific interventions and drawing attention to the needs of patients with advanced disease. The new diagnosis would be an addition to nursing science and would provide a framework for providing care to people with advanced disease who express such a wish. Nurses would gain professional autonomy about identifying, exploring and responding clinically to such a wish.
Telehealth palliative care interventions for patients with advanced cancer: a scoping review
Authors: Mathews Jean Jacob , Chow Ronald , Wennberg Erica , Lau Jenny , Hannon Breffni , Zimmermann Camilla 
Published: May 2023

Abstract

Purpose:Telehealth allows patients to maintain contact with healthcare providers without necessitating travel, and is becoming increasingly utilized. The purpose of this study is to describe the components of telehealth palliative care interventions for patients with advanced cancer before the COVID-19 pandemic; identify any intervention components associated with improvements in outcomes; and evaluate reporting of interventions.
Methods: This scoping review was registered on the Open Science Framework. We searched 5 medical databases from inception to June 19, 2020. Inclusion criteria were: age ≥18, advanced cancer, asynchronous or synchronous telehealth intervention, and specialized palliative care interventions in any setting. We assessed the quality of intervention reporting using the Template for Intervention Description and Replication (TIDieR) checklist.
Results: Twenty-three studies met the inclusion criteria: 15 (65%) quantitative (7 randomized controlled trials, 5 feasibility trials, 3 retrospective chart reviews); 4 (17%) mixed methods, and 4 (17%) qualitative. Most quantitative and mixed methods studies were conducted in North America (12/19, 63%), reported on hybrid (in-person and telehealth) interventions (9/19, 47%), and were delivered by nurses (12/19, 63%) in the home setting (14/19, 74%). In most studies that reported improvements in patient- or caregiver-reported outcomes, the content was psychoeducational and resulted in improvements for psychological symptoms. No study provided complete reporting on all 12 TIDieR checklist items.
Conclusion: Telehealth studies are needed that reflect palliative care’s mission to provide multidisciplinary team-based care that improves quality of life in diverse settings, and that provide detailed reporting of interventions.
HDL inhibits inflammation by suppressing dendritic cell maturation and modulating CD4+ T cell subtypes in collagen-induced arthritis mice
Authors: Wang Xin , Lu Shulai , Li Dong , Zhang Juan , Dong Qingzhe , Jia Dongmei , Wang Yunlong , Liu Bin 
Published: May 2023

Abstract
Background
To investigate the mechanism of anti-inflammatory effect of High-density lipoprotein (HDL) in collagen-induced arthritis (CIA) mice.
Methods
The CIA animal model was constructed, and the mice were separated into three groups: control, CIA and CIA + HDL. In the CIA + HDL group, HDL was given on day 40, and an additional injection was administered every 3 days for a total of five doses. The levels of mouse HDL were measured by using ELISA kits, and liver, heart, kidney and colon tissue sections were stained with H&E. Additionally, the splenic CD4 + T cell phenotypes in each group were analyzed. Immature DCs were stimulated with LPS in the presence or absence of HDL, and the expression of surface markers was investigated by FACS.
Results
HDL decreased the ratio of Th1/Th2 cells and increased the Th1/Th17 cell ratio in the CIA + HDL group compared with those of the CIA one (P < 0.05). In vitro, the expression of MHC-II, CD86, and CD40 in CD11c + BMDCs was suppressed by HDL. The level of HDL in the CIA group was significantly reduced compared with that of the control one (P < 0.05), and there were no significant pathological changes in the liver, heart, kidney and colon tissues of the mice among the three groups.
Conclusion
HDL exerts anti-inflammatory effect in CIA mice by suppressing DCs maturation and modulating CD4 + T cell subtypes.
Non-destructive prediction of rosmarinic acid content in basil plants using a portable hyperspectral imaging system and ensemble learning algorithms
Authors: Yoon Hyo In , Ryu Dahye , Park Jai-Eok , Kim Ho-Youn , Yang Jung-Seok , Park Soo Hyun 
Published: May 2023

Abstract

Background: Rosmarinic acid (RA) is a phenolic antioxidant naturally occurring in plants of the Lamiaceae family, including basil (Ocimum basilicum L.). Existing analytical methods for determining RA content in leaves are time-consuming and destructive, which poses limitations on quality assessment and control during cultivation. In this study, we aimed to develop non-destructive prediction models for RA content in basil plants using a portable hyperspectral imaging (HSI) system and machine learning algorithms. The basil plants were grown in a vertical farm module with controlled environments, and the HSI of the whole plant was captured using a portable HSI camera in the range of 400–850 nm. The average spectra were extracted from the segmented regions of the plants. We employed several spectral data pre-processing methods and ensemble learning algorithms, such as Random Forest, AdaBoost, XGBoost, and LightGBM, to develop the RA prediction model and feature selection based on feature importance.
Results: The best RA prediction model was the LightGBM model with feature selection by AdaBoost algorithm and spectral pre-processing through logarithmic transformation and 2nd derivative. This model performed satisfactorily for practical screening with R2p = 0.81 and RMSEP = 3.92. The HSI images obtained using the developed model successfully estimated and visualized the RA distribution in basil plants growing in the greenhouse.
Conclusions: Our findings demonstrate the potential use of a portable HSI system for monitoring and controlling pharmaceutical quality in medicinal plants during cultivation. This non-destructive and rapid method can provide a valuable tool for assessing the quality of RA in basil plants, thereby enhancing the efficiency and accuracy of quality control during the cultivation stage.
Scientific note: behavioral dynamics of pollen storage in Melipona quadrifasciata
Authors: Miranda-Pinto Patrícia , Cappelini Luciana Teresa Dias , MORAIS MICHELLE MANFRINI 
Published: May 2023

Abstract
Stingless bees are important eusocial insects found in tropical and subtropical regions. They store nectar and pollen from flowers to survive periods of scarcity. During storage, nectar and pollen undergo fermentation processes, resulting in honey and fermented pollen. However, the fermentation process of pollen collected by stingless bees is not well understood. Understanding these processes not only clarifies pollen fermentation in different stingless bee species but also sheds light on the transformation process of pollen. This knowledge can be applied to produce fermented feeds using specific microorganisms. Therefore, this study aimed to observe pollen storage behavior within colonies to understand the fermentation process and aid in the development of fermented feeds for bees. A Melipona quadrifasciata colony from the Experimental Meliponary of the Universidade Federal de São Paulo, Brazil, was observed for 30 days. Daily observations were conducted in the morning and night, and pollen pots were marked with random colors to differentiate them and collect data on worker bee dynamics. Observations showed no consistent patterns in the opening and closing of the pots, with worker bees frequently entering and exiting the open pollen pots. This suggests an ongoing fermentation process involving gas exchange and nutrient flow. The lack of regularity in handling pollen storage in M. quadrifasciata indicates its noteworthy variability. These findings are crucial for advancing meliponiculture techniques and developing fermented protein supplements globally and locally.
Time-series Analysis of Slope Displacements using UAV Photogrammetry and its Relationship with Rainfall Intensity
Authors: Kim Namgyun , Macciotta Renato , jun byonghee 
Published: May 2023

Abstract

In this study, UAV (Unmanned Aerial Vehicle) photogrammetry was used to monitor the ground displacement on the slope below a coal waste-rock stockyard, and to investigate the role of rainfall on its displacement. The study area is a mountainous region in Korea, where coal mining is active, and coal waste-rock is stored on the slopes of the mountain. In this area, material removal work was undertaken to reduce the steepness of the slope and driving forces in order to prevent disasters, but the strategy requires continuous monitoring to confirm the stabilization of the slope. For slope monitoring, a total of six UAV photogrammetry campaigns were conducted between April 2019 and August 2020. As a result of data processing, an orthoimage and DSM (Digital Surface Model) were generated. The ground displacement was estimated through four steps: slope extraction, displacement area evaluation, horizontal displacement, and vertical displacement analysis. During the study period, the maximum vertical displacement was 3.3 m and the maximum horizontal displacement was 3.5 m. The horizontal displacement was effectively evaluated through the measurement of the movement of the drainage system using orthoimages captured with a periodic survey. The effects of rainfall on ground displacement were also investigated. A very clear linear relationship between rainfall intensity higher than 20mm/d and ground displacement was identified. Accumulated amount of rainfall also showed good correlation with slope movement, but the frequency of rainfall intensity below 20 mm/d showed relatively low correlation with ground displacements.