bluuebunny/crossref_metadata_2025_split huggingface dataset:
Why I am not an Anti-Haecceitist
Authors: Nizzardo Matteo 
Published: January 2023

AbstractIn this paper I argue that if the Identity of Indiscernibles is not necessarily true, then Haecceitism ensues—where Haecceitism is the view that there are maximal possibilities that include all the same qualitative possibilities, and yet differ with respect to the non-qualitative possibilities they include. This goes against the common intuition that Anti-Haecceitism is compatible with the Identity of Indiscernibles being only contingently true. My argument is interesting in many respects. First, it shows that in any modal framework there is a connection between the number of worldbound ordinary spatio-temporal objects, and the number of overall possibilities. Second, it has repercussions for the tenability of some philosophical positions, like Generalism, which is usually interpreted as entailing Anti-Haecceitism while at the same time being compatible with the claim that the Identity of Indiscernibles is not necessarily true. If I am correct, Generalism and similar philosophical accounts turn out to be inconsistent. Finally, it provides a strong argument for Haecceitism, given that the majority of authors today find counterexamples to the Identity of Indiscernibles extremely convincing, and many philosophical positions have been and continue being criticised on the basis of their commitment to the Identity of Indiscernibles. The paper is structured as follows: I introduce Haecceitism and the Identity of Indiscernibles in Sects. 1 and 2 respectively. Drawing on a result from the Philosophy of Quantum Mechanics, which I survey in Sect. 3, I give my main argument in Sect. 4. Finally, I discuss some implications in Sect. 5.
Data quality and auditing within the Netherlands Heart Registration: using the PCI registry as an example
Authors: Houterman S. , van Dullemen A. , Versteegh M. , Aengevaeren W. , Danse P. , Brinkman E. , Schuurman D. , van Veghel D. ,   PCI Registration Committee of the Netherlands Heart Registration
Published: January 2023

Abstract
Aim
The aim of this article is to present the method and results of the data quality control system and au﻿dit within the Netherlands Heart Registration (NHR) using data of patients treated with percutaneous coronary intervention (PCI) in the Netherlands as an example.

Methods
The NHR is a Dutch nationwide registry of all cardiac interventions, comprising data from all 71 hospitals, of which 30 are cardiac intervention or heart centres. Each year, within the NHR, data validation and verification is performed by standard quality controls and monitoring visits (audits). For the audit in 2019, a sample of 50–100 medical records of patients treated with PCI in 2016 and 2017 were reviewed in each hospital by an independent audi﻿tor. The data received by the NHR were compared with the information in the hospitals’ medical records. In to﻿tal 12 patient characteristics, 5 intervention variables and 3 outcome variables were screened. The value of a variable was considered discrepant if more than 10% of the medical records reviewed regarding this variable were not consistent with the reported data received by the NHR.

Results
For all variables together, the consistency was high, 97.6%. All variables, except multivessel disease (9.3% discrepancy in the 2622 medical records reviewed), had an accuracy above 95%.

Conclusion
The results of the audit of the PCI medical records show that the overall quality of the data is high. For variables such as multivessel disease it is important to improve knowledge of the definitions and to train all those involved in the registration process.
Quality of life and societal costs in hypertrophic cardiomyopathy: protocol of the AFFECT-HCM study
Authors: Schoonvelde Stephan A. C. , Wiethoff Isabell , Hiligsmann Mickaël , Evers Silvia M. A. A. , Michels Michelle 
Published: January 2023

Abstract
Background
Ever since the first description of hypertrophic cardiomyopathy (HCM), the most common genetic cardiac disease, tremendous progress has been made in the evaluation and management of HCM patients, but little attention has been focused on the impact of HCM on societal costs and quality of life (QoL).

Aims
This paper describes the study protocol for the AFFECT-HCM study into burden of disease (BoD), which aims to estimate health-related QoL and societal costs in HCM patients and genotype-positive phenotype-negative (G+/P−) relatives during a one-year follow-up study, and relate this to the phenotypical HCM expression.

Methods
A total of 400 Dutch HCM patients and 100 G+/P− subjects will be followed for one year in a prospective, multi-centre, prevalence-based BoD study. Societal costs will be measured via a bottom-up approach using the cost questionnaires iMCQ and iPCQ. For QoL, the generic EQ-5D-5L and disease-specific Kansas City Cardiomyopathy Questionnaire will be used. QoL and societal costs will be compared with phenotype-specific HCM characteristics and other determinants to identify factors that influence BoD. Accelerometry will test the correlation between BoD and physical activity.

Conclusion
The AFFECT-HCM study will evaluate the BoD in HCM patients and G+/P− subjects to improve the understanding of the societal and economic impact of HCM.
Agios Petros and the Neolithic pottery-making traditions of the deserted islands, Northern Sporades, Greece
Authors: Barouda Archontoula , Quinn Patrick , Efstratiou Nikos 
Published: January 2023

Abstract
The Neolithic sites of the Cyclops Cave and Agios Petros provide insights into a once flourishing culture that inhabited the ‘Deserted Islands’ of the northern Sporades in the Greek north Aegean. Building on scientific analysis of ceramics from the seasonally inhabited Cyclops Cave, the present study examines in detail 39 sherds from the permanently settled site of Agios Petros on the adjacent island of Kyra Panagia, using a combination of thin section petrography, geochemistry, scanning electron microscopy and X-ray diffraction. The two ceramic assemblages have been directly compared, revealing close similarities and differences that provide insights into the relationship between the neighbouring sites and their functions. The chaîne opératoire of the dominant local pottery-making tradition of the Deserted Islands is reconstructed and its implications for the identity of the Agios Petros-Yioura/Northern Sporades Culture are considered.
Meditators Probably Show Increased Behaviour-Monitoring Related Neural Activity
Authors: Bailey Neil W. , Geddes Harry , Zannettino Isabella , Humble Gregory , Payne Jake , Baell Oliver , Emonson Melanie , Chung Sung Wook , Hill Aron T. , Rogasch Nigel C. , Hohwy Jakob , Fitzgerald Paul B. 
Published: January 2023

AbstractObjectivesMindfulness meditation is associated with better attention function. Performance monitoring and error-processing are important aspects of attention. We investigated whether experienced meditators showed different neural activity related to performance monitoring and error-processing. Previous research has produced inconsistent results. This study used more rigorous analyses and a larger sample to resolve the inconsistencies.MethodWe used electroencephalography (EEG) to measure the error-related negativity (ERN) and error positivity (Pe) following correct and incorrect responses to a Go/Nogo task from 27 experienced meditators and 27 non-meditators.ResultsNo differences were found in the ERN (allp > 0.05). Meditators showed larger global field potentials (GFP) in the Pe after correct responses and errors, indicating stronger neural responses (p = 0.019, FDR-p = 0.152, np2 = 0.095, BFincl = 2.691). This effect did not pass multiple comparison controls. However, single-electrode analysis of the Pe did pass multiple comparison controls (p = 0.002, FDR-p = 0.016, np2 = 0.133, BFincl = 220.659). Meditators also showed a significantly larger Pe GFP for errors, which would have passed multiple comparison controls, but was not a primary analysis (p = 0.003, np2 = 0.149, BF10 = 9.999).ConclusionsMeditation may strengthen neural responses related to performance monitoring. However, these strengthened neural responses were not specific to error monitoring (although the error-related Pe may be more sensitive to group differences than the correct response Pe). These conclusions remain tentative, because the single-electrode analysis passed multiple comparison controls, but the analysis including all electrodes did not.PreregistrationThis study was not preregistered.
Recent developments of common numerical methods and common experimental means within the framework of the large passenger aircraft program
Authors: Boden F. , Barth H. P. , Hein S. , Heitmann D. , Kirmse T. , Klein C. , Krüger W. , Lemarechal J. , Norambuena M. , Schäfer D. , Schnell R. , Sinha K. , Theiß A. , Weiss A. 
Published: January 2023

AbstractFor the exploration and validation of the integration of efficient propulsion concepts and new technologies for future large passenger aircraft, it is necessary to establish suitable design, evaluation and measurement tools. Therefore, as one major activity of the Large Passenger Aircraft (LPA) Platform 1 of the Clean Sky 2 initiative, the so-called Cross-Capability Demonstrator (XDC), has been set up to develop and demonstrate powerful numerical and experimental methods for aerodynamic, aeroacoustics, and aeroelastic simulation and measurement tasks. The paper will give an overview of the activities to be performed within the XDC and present some of the latest achievements related to this demonstrator.
Bias-Independent Inter-Modulation Method for Simultaneously Measuring Low-Frequency Modulation and Bias Half-Wave Voltages of Mach-Zehnder Modulators
Authors: Zhu Junfeng , Zou Xinhai , Xu Ying , He Yutong , Zhang Yali , Zhang Zhiyao , Zhang Shangjian , Liu Yong 
Published: January 2023

AbstractA bias-independent inter-modulation method is proposed and demonstrated for measuring low-frequency modulation and bias half-wave voltages of Mach-Zehnder modulators (MZMs). The method consists of simultaneous sinusoidal modulation on the modulation and bias ports of the MZM under test. Sinusoidal-modulated sidebands heterodyne with each other and generate the desired inter-modulation products after photodetection, which allows extracting both the modulation depth and half-wave voltage for the modulation and bias ports of the MZM. Our method is independent of bias voltages of the MZM, which can be canceled out by carefully choosing the sinusoidal-modulation frequencies. Moreover, the proposed method enables the low swing voltage for measuring both the modulation depth and half-wave voltage of MZMs. Experiments indicate that the proposed method features the simple setup and high accuracy for low-frequency response measurement ranging from 1 Hz to 1 MHz.
Carbonic anhydrases III and IX are new players in the crosstalk between adrenocortical carcinoma and its altered adipose microenvironment
Authors: Fei L. , Cantini G. , Nocentini A. , Nardini P. , Catarinicchia S. , Canu L. , Ercolino T. , Quartararo G. , Nesi G. , Gacci M. , Maggi M. , Hantel C. , Mannelli M. , Supuran C. T. , Luconi M. 
Published: January 2023

Abstract
Purpose
Adrenocortical carcinoma (ACC), a rare malignancy of the adrenocortex, is characterized by a crosstalk between the adipose microenvironment and tumor. Here, we assessed the involvement of carbonic anhydrase (CA) enzymes III and IX (CAIII and CAIX), in the metabolic alterations of the adipose tissue characterizing obesity and in the local crosstalk between the tumor adipose microenvironment and ACC.

Results/methods
CAIII and CAIX expression is altered in visceral adipose tissue (VAT) in obesity and in ACC. A significant CAIX upregulation was present in ACC at advanced stages (n = 14) (fold increase FI = 7.4 ± 0.1, P < 0.05) associated with lower CAIII levels (FI = 0.25 ± 0.06, P < 0.001), compared with lower stages (n = 9). In vitro coculture between visceral adipose stem cells (ASCs) and ACC cell lines, H295R and MUC-1, mimicking the interaction occurring between VAT and advanced ACC, showed a significant CAIX upregulation in H295R but not in MUC-1 cells, and a decreased expression of CAIII. The effect on adipose cells was different when cocultured with H295R or MUC-1 cells. Coculture did not modulate CAIII expression in ASCs, which, however, was significantly downregulated with H295R (FI = 0.34 ± 0.11, P < 0.05) and upregulated by MUC-1 when cocultured ASCs were induced to differentiate toward adipocytes, with an expression profile similar to what found in VAT of obese subjects. CAIX expression was markedly increased in ASCs cocultured with H295R and to a less extent following adipogenesis induction (FI = 150.9 ± 46.5 and FI = 4.6 ± 1.1, P < 0.01, respectively).

Conclusion
Our findings highlight a modulation of CAIII and CAIX in the metabolic crosstalk between ACC and its local adipose microenvironment, suggesting that CAs might represent a potential target for novel anticancer therapies.
Die Biomarker BNP und NT‑proBNP
Authors: Oremek G. M. , Passek K. , Holzgreve F. , von der Eltz V. , Dröge J. 
Published: January 2023

ZusammenfassungDie vorliegende Übersicht über die Biomarker BNP und NT-pro-BNP wird im Rahmen der Serie „Biomarker“ des Zentralblatts für Arbeitsmedizin, Arbeitsschutz und Ergonomie publiziert, die sich mit dem immer häufigeren Gebrauch der Bestimmung von spezifischen Markern bei sog. Manager-Vorsorgen und Check-up-Untersuchungen beschäftigt. BNP und NT-pro-BNP eignen sich grundsätzlich als Marker zur Diagnosestellung der akuten und chronischen Herzinsuffizienz sowie zur Verlaufsbeurteilung. Hier zeigen diese eine hohe Sensitivität und Spezifität.
The Process of Supporting Careers for Young Adults with Mental Health Problems: Case Study of a Supported Education Program
Authors: Liljeholm Ulrika , Hillborg Helene , Argentzell Elisabeth , Lövgren Veronica , Rosenberg David , Bejerholm Ulrika 
Published: January 2023

AbstractMental health problems often appear at a young age. As the labour market places higher demands for education and competence, mental health services are focusing on young adults’ support needs for school and career opportunities. This study is a single case of an integrated supported education and employment unit in Sweden over an 18-month period. Multiple data sources illustrate the process of supporting careers and transition to school and work for young service users. This is a promising example of how careers can be supported through a flexible service that provides support for successful individual education and work trajectories among the youth. The service allowed for evolution of an identity process towards recovery through student and work roles.
A tree- and climate-dependent growth model to predict mature annual cork thickness under different climate change scenarios
Authors: Paulo Joana Amaral , Firmino Paulo Neves , Tomé Margarida 
Published: January 2023

AbstractClimatic factors drive the annual growth of cork and the subsequent increase in its thickness, which, in addition to porosity, determines the price of cork. Therefore, the simulation of cork thickness is a crucial module of forest growth simulators for cork oak stands. As the existing cork growth models are independent of climatic factors, cork thickness under different climate change scenarios could not be simulated using these models. The primary objective of this study was to develop a climate-dependent tree model to predict annual cork growth. We also verified the hypothesis that the effects of climate change on cork annual growth are nonlinear, and vary with the cork age and thickness. Due to the limited amount of work developed around this topic, we evaluated three candidate models and selected the one that presented best prediction performance as the base model. A set of climate variables that characterized annual climatic conditions were tested in the base model parameters. The resulting climate-dependent model was referred to as the fixed-effects model, and used to initialize a mixed-effect model which accounted for the nested structure of the data. We considered two random effects—the plot and the trees inside the plot. Annual precipitation and the Lang index (ratio between annual precipitation and mean annual temperature) were the variables that showed best results when included in the model parameters. Using a ratio of the variable to cork thickness recorded during the previous year, in both cases, suggested a decline of the positive effect of annual precipitation and the Lang index for increasing cork thickness. The models developed in this study predicted the cork thickness of individual trees based on the cork age and under different climate change scenarios. Therefore, they can be used in forest growth simulators for forest management and research purposes.
On $$\alpha $$-Excellent Graphs
Authors: Dettlaff Magda , Henning Michael A. , Topp Jerzy 
Published: January 2023

AbstractA graph G is $$\alpha $$
α
-excellent if every vertex of G is contained in some maximum independent set of G. In this paper, we characterize $$\alpha $$
α
-excellent bipartite graphs, $$\alpha $$
α
-excellent unicyclic graphs, $$\alpha $$
α
-excellent simplicial graphs, $$\alpha $$
α
-excellent chordal graphs, $$\alpha $$
α
-excellent block graphs, and we show that every generalized Petersen graph is $$\alpha $$
α
-excellent.
A Novel Link Prediction Framework Based on Gravitational Field
Authors: Yang Yanlin , Ye Zhonglin , Zhao Haixing , Meng Lei 
Published: January 2023

AbstractCurrently, most researchers only utilize the network information or node characteristics to calculate the connection probability between unconnected node pairs. Therefore, we attempt to project the problem of connection probability between unconnected pairs into the physical space calculating it. Firstly, the definition of gravitation is introduced in this paper, and the concept of gravitation is used to measure the strength of the relationship between nodes in complex networks. It is generally known that the gravitational value is related to the mass of objects and the distance between objects. In complex networks, the interrelationship between nodes is related to the characteristics, degree, betweenness, and importance of the nodes themselves, as well as the distance between nodes, which is very similar to the gravitational relationship between objects. Therefore, the importance of nodes is used to measure the mass property in the universal gravitational equation and the similarity between nodes is used to measure the distance property in the universal gravitational equation, and then a complex network model is constructed from physical space. Secondly, the direct and indirect gravitational values between nodes are considered, and a novel link prediction framework based on the gravitational field, abbreviated as LPFGF, is proposed, as well as the node similarity framework equation. Then, the framework is extended to various link prediction algorithms such as Common Neighbors (CN), Adamic-Adar (AA), Preferential Attachment (PA), and Local Random Walk (LRW), resulting in the proposed link prediction algorithms LPFGF-CN, LPFGF-AA, LPFGF-PA, LPFGF-LRW, and so on. Finally, four real datasets are used to compare prediction performance, and the results demonstrate that the proposed algorithmic framework can successfully improve the prediction performance of other link prediction algorithms, with a maximum improvement of 15%.
Environmental Activism and the Fairness of Costs Argument for Uncivil Disobedience
Authors: LAI TEN-HERNG , LIM CHONG-MING 
Published: January 2023

AbstractSocial movements often impose nontrivial costs on others against their wills. Civil disobedience is no exception. How can social movements in general, and civil disobedience in particular, be justifiable despite this apparent wrong-making feature? We examine an intuitively plausible account—it is fair that everyone should bear the burdens of tackling injustice. We extend this fairness-based argument for civil disobedience to defend some acts of uncivil disobedience. Focusing on uncivil environmental activism—such as ecotage (sabotage with the aim of protecting the environment)—we argue that some acts of uncivil disobedience can be morally superior to their civil counterparts, when and because such acts target people who are responsible for environmental threats. Indeed, insofar as some acts of uncivil disobedience can more accurately target responsible people, they can better satisfy the demands of fairness compared to their civil counterparts. In some circumstances, our argument may require activists to engage in uncivil disobedienceeven whencivil disobedience is available.
Predicting the last zero before an exponential time of a spectrally negative Lévy process
Authors: Baurdoux Erik J. , Pedraza José M. 
Published: January 2023

AbstractGiven a spectrally negative Lévy process, we predict, in an
$L_1$
sense, the last passage time of the process below zero before an independent exponential time. This optimal prediction problem generalises [2], where the infinite-horizon problem is solved. Using a similar argument as that in [24], we show that this optimal prediction problem is equivalent to solving an optimal prediction problem in a finite-horizon setting. Surprisingly (unlike the infinite-horizon problem), an optimal stopping time is based on a curve that is killed at the moment the mean of the exponential time is reached. That is, an optimal stopping time is the first time the process crosses above a non-negative, continuous, and non-increasing curve depending on time. This curve and the value function are characterised as a solution of a system of nonlinear integral equations which can be understood as a generalisation of the free boundary equations (see e.g. [21, Chapter IV.14.1]) in the presence of jumps. As an example, we numerically calculate this curve in the Brownian motion case and for a compound Poisson process with exponential-sized jumps perturbed by a Brownian motion.
Portfolio performance under benchmarking relative loss and portfolio insurance: From omega ratio to loss aversion
Authors: Ng Tak Wa , Nguyen Thai 
Published: January 2023

AbstractWe study an optimal investment problem under a joint limited expected relative loss and portfolio insurance constraint with a general random benchmark. By making use of a static Lagrangian method in a complete market setting, the optimal wealth and investment strategy can be fully determined along with the existence and uniqueness of the Lagrangian multipliers. Our numerical demonstration for various commonly used random benchmarks shows a trade-off between the portfolio outperformance and underperformance relative to the benchmark, which may not be captured by the widely used Omega ratio and its utility-transformed version, reflecting the impact of the benchmarking loss constraint. Furthermore, we develop a new portfolio performance measurement indicator that incorporates the agent’s utility loss aversion relative to the benchmark via solving an equivalent optimal asset allocation problem with a benchmark-reference-based preference. We show that the expected utility performance is well depicted by looking at this new portfolio performance ratio, suggesting a more suitable portfolio performance measurement under a limited loss constraint relative to a possibly random benchmark.