bluuebunny/crossref_metadata_2025_split huggingface dataset:
Telling a different story: Historiography, ethics, and possibility for nursing
Authors: Dillard‐Wright Jessica 
Published: May 2023

AbstractWith this paper, I will interrogate some of the implications of nursing's dominant historiography, the history written by and about nursing, and its implications for nursing ethics as a praxis, invoking feminist philosopher Donna Haraway's mantra that ‘it matters what stories make worlds, what worlds make stories.’ First, I will describe what I have come to understand as the nursing imaginary, a shared consciousness constructed both by nurses from within and by those outside the discipline from without. This imaginary is fashioned in part by the histories nursing produces about the discipline, our historical ontology, which is demonstrative of our disciplinary values and the ethics we practice today. I assert that how we choose to constitute ourselves as a discipline is itself an ethical endeavour, bound up with how we choose to be and what we allow as knowledge in nursing. To animate this discussion, I will outline the received historiography of nursing and dwell in the possibilities of thinking about Kaiserswerth, the training school that prepared Nightingale for her exploits in Crimea and beyond. I will briefly consider the normative values that arise from this received history and consider the possibilities that these normative values foreclose upon. I then shift the frame and ask what might be possible if we centred Kaiserswerth's contested legacy as a training school for formerly incarcerated women, letting go of the sanitary and sanitised visions of nursing as Victorian angels in the hospital. Much energy over the past 250 years has been invested in the professionalisation and legitimation of nursing, predicated (at least in our shared imaginary) on the interventions of Florence Nightingale, but this is one possibility of many. I conclude with a speculative dream of the terrain opens up for nursing if we shed this politics and ethos of respectability and professionalism and instead embrace community, abolition and mutual aid as organising values for the discipline.
Effect of different types of exercise on fitness in people with multiple sclerosis: A network meta‐analysis
Authors: Reina‐Gutiérrez Sara , Meseguer‐Henarejos Ana Belén , Torres‐Costoso Ana , Álvarez‐Bueno Celia , Cavero‐Redondo Iván , Núñez de Arenas‐Arroyo Sergio , Guzmán‐Pavón María José , Sánchez‐López Mairena , Martínez‐Vizcaíno Vicente 
Published: May 2023

BackgroundIt is assumed that people with multiple sclerosis (MS) who participate in programs of physical exercise improve their physical fitness.ObjectiveThe aim of this network meta‐analysis (NMA) was to analyze the effect of different types of exercise on muscular fitness and cardiorespiratory fitness (CRF) among people with MS and to determine the best type of exercise according to disease severity.MethodsMEDLINE, the Physiotherapy Evidence Database, the Cochrane Library, SPORTDiscus, Scopus, and Web of Science were searched from inception to April 2022 to identify randomized controlled trials (RCTs) concerning the effect of physical exercise on fitness in people with MS. We ranked the types of physical exercise by calculating the surface under the cumulative ranking (SUCRA).ResultsWe included 72 RCTs involving 2543 MS patients in this NMA. A ranking of five types of physical exercise (aerobic, resistance, combined [aerobic and resistance], sensorimotor training, and mind–body exercises) was achieved. Combined and resistance training had the highest effect sizes (0.94, 95% CI 0.47, 1.41, and 0.93, 95% CI 0.57, 1.29, respectively) and the highest SUCRA (86.2% and 87.0%, respectively) for muscular fitness. The highest effect size (0.66, 95% CI 0.34, 0.99) and SUCRA (86.9%) for CRF was for aerobic exercise.ConclusionsCombined and resistance training seem to be the most effective exercises to improve muscular fitness and aerobic exercise for CRF in people with MS.
Piebaldism with café‐au‐lait macules resulting from a novel mutation of KIT gene in a three‐generation Chinese family
Authors: Li Xiaorong , Xing Xiaojing , Liang Xiaoqiang , Song Cuihao , Yang Jie , Ren Dan , Zhou Yong 
Published: May 2023

AbstractBackgroundPiebaldism is a rare, autosomal dominant, and congenital pigmentary disorder characterized by stable depigmentation of the skin and white forelock. Mutations in KIT or SLUG genes result in piebaldism. Most individuals with piebaldism have a family history of the disorder.MethodsIn this paper, we report a case of piebaldism with café‐au‐lait macules resulting from a novel mutation of KIT gene c.1982C > T (p.Thr661Ile) in a three‐generation Chinese family. The whole‐exome sequencing, mitochondrial gene 3000X, and bioinformatics tools were used to identify the mutation in this new‐found pedigree. In addition, we searched the databases of “Punmed, Chinese National Knowledge Infrastructure, CMJD, WANFANG MED ONLINE”, reviewed 88 cases of piebaldism caused by KIT gene mutation, and summarized the relationship between clinical phenotype and genotype of piebaldism through logistic regression and other statistical methods.ResultsThe proband and her affected mother carried a heterozygous c.1982C > T missense mutation (p.Thr661Ile) on KIT gene. Bioinformatics analysis hinted that it had potential pathogenicity. The data showed that piebaldism patients with cafè‐au‐lait macules had KIT mutations almost located in the intracellular tyrosine kinase domain and were mostly related to the severe clinical phenotype of piebaldism.ConclusionThe new heterozygous c.1982C > T missense mutation on KIT caused piebaldism with café‐au‐lait macules in this Chinese family. This study provides a new reference index for clinicians to judge the severity of clinical phenotypes of piebaldism, broadens the understanding of the correlation between clinical phenotypes and genotypes of piebaldism, and provides reference of genetic counseling and prenatal diagnosis for affected families.
A novel optical coherence tomography‐based in vitro method of anti‐aging skin analysis using 3D skin wrinkle mimics
Authors: Min Daejin , Ahn Yujin , Lee Hae Kwang , Jung Woonggyu , Kim Hyoung‐June 
Published: May 2023

AbstractBackgroundWrinkles represent a characteristic symptom of skin aging. In recent years, various studies have focused on their prevention and/or cure. However, clinical tests are still the only method available to directly detect and evaluate the anti‐wrinkle efficacy of various substances. Moreover, no in vitro strategy for such anti‐aging skin analysis has been reported. Therefore, in this study, we aimed to develop a novel technology to overcome these limitations.Materials and methodsFull‐thickness (FT) skin wrinkle mimics with various widths and depths were fabricated using a collagen stamping method. These were analyzed and compared using 2D and 3D Swept Source‐Optical Coherence Tomography (SS‐OCT) imaging technologies.ResultsSS‐OCT demonstrated superficial and cross‐sectional images of the wrinkle mimics, and the size of the wrinkles was validated using image analysis. Retinoic acid treatment significantly decreased both the depth and width of wrinkles formed in the FT skin wrinkle mimics.ConclusionsUsing 3D tissue engineering and SS‐OCT imaging technologies, we developed a novel in vitro technique that can directly detect skin wrinkles. This significantly efficient method could lead to an alternative strategy for animal experiments and preclinical anti‐aging research on the skin.
Low Overpotential Electroreduction of CO2 on Porous SnO2/ZnO Catalysts
Authors: Sun Qi , Liu Jianqi , Zhou Bo , Liu Yanping , Tang Yang , Wan Pingyu , Hu Qing , Yang Xiao Jin 
Published: May 2023

Abstract
SnO2-based materials are promising catalysts for CO2 electrochemical reduction due to their attractive selectivity for C1 products (formate and carbon monoxide) but they tend to suffer high overpotential and poor stability. Here, a porous SnO2/ZnO catalyst is synthesized via hydroxides coprecipitation, hydrothermal treatment, and carbon black template calcination. SnO2 nanocrystals are produced by calcination of tin hydroxides while the growth of ZnO nanocrystals is associated with carbon black template. The porous SnO2/ZnO catalyst presents a stable Faradaic efficiency of &gt;90% for CO2 reduction at an applied voltage of −0.7 V versus reversible hydrogen electrode and a C1 current density of 9.53 mA/cm2 over a testing period of 100 h. The improved performance is originated from abundant hetero-junctions and lattice defects of SnO2 and ZnO nanocrystals, large specific surface area, and grain boundary. This study provides a facile method to fabricate porous and nanocrystal metal oxides electrocatalysts for electrochemical processes.
Study on the Bending Behaviors of a Novel Flexible Re-Entrant Honeycomb
Authors: Zhou Yang , Pan Yi , Chen Lin , Gao Qiang , Sun Beibei 
Published: May 2023

Abstract
In order to further improve the bending performance of the traditional re-entrant (RE) honeycomb, a novel auxetic honeycomb architecture, called RE-L honeycomb, was proposed by adding an additional link-wall structure to the RE cell. The bending behaviors of the novel RE-L honeycomb, including the properties under linear elastic deformation and the bending behaviors under large deformation, were comprehensively investigated by the analytical, numerical, and experimental models. Results show that the proposed RE-L honeycomb significantly improves the bending compliance in the x-direction due to the highly flexible performance of the additional structure, where the bending rigidity and the maximum bending force are only 23% and 29.4% of those of the RE honeycomb, respectively. Besides, the additional structure obviously improves the designability and orthotropic properties of the original auxetic honeycomb. In conclusion, the proposed RE-L shows improved bending performance, which deserves more attention in future research and related applications.
Socioeconomic inequalities in interval colorectal cancer are explained by differences in faecal haemoglobin concentration and age: a register-based cohort study
Authors: Deding Ulrik , Kobaek-Larsen Morten , Bøggild Henrik , Kaalby Lasse , Thygesen Marianne Kirstine , Baatrup Gunnar 
Published: May 2023

ObjectiveTo estimate the risk of interval colorectal cancer (CRC) in faecal immunochemical test (FIT) negative screening participants according to socioeconomic status.DesignIn this register-based study, first round FIT negative (<20 µg hb/g faeces) screening participants (biennial FIT, citizens aged 50–74) were followed to estimate interval CRC risk. Multivariate Cox proportional hazard regression models estimated HRs based on socioeconomic status defined by educational level and income. Models were adjusted for age, sex and FIT concentration.ResultsWe identified 829 (0.7‰) interval CRC in 1 160 902 individuals. Interval CRC was more common in lower socioeconomic strata with 0.7‰ for medium-long higher education compared with 1.0‰ for elementary school and 0.4‰ in the highest income quartile compared with 1.2‰ in the lowest. These differences did not translate into significant differences in HR in the multivariate analysis, as they were explained by FIT concentration and age. HR for interval CRC was 7.09 (95% CI) for FIT concentrations 11.9–19.8 µg hb/g faeces, and 3.37 (95% CI) for FIT between 7.2 and 11.8 compared with those <7.2. The HR rose with increasing age ranging from 2.06 (95% CI 1.45 to 2.93) to 7.60 (95% CI 5.63 to 10.25) compared with those under 55 years.ConclusionInterval CRC risk increased with decreasing income, heavily influenced by lower income individuals more often being older and having increased FIT concentrations. Individualising screening interval based on age and FIT result, may decrease interval CRC rates, reduce the social gradient and thereby increase the screening efficiency.
Prevention of COVID-19 with oral vitamin D supplemental therapy in essential healthcare teams (PROTECT): protocol for a multicentre, triple-blind, randomised, placebo-controlled trial
Authors: Ducharme Francine Monique , Tremblay Cécile , Golchi Shirin , Hosseini Banafsheh , Longo Cristina , White John H , Coviello Decio , Quach Caroline , Ste-Marie Louis-Georges , Platt Robert W 
Published: May 2023

IntroductionIn the COVID-19 pandemic, healthcare workers (HCWs) were at high risk of infection due to their exposure to COVID infections. HCWs were the backbone of our healthcare response to this pandemic; every HCW withdrawn or lost due to infection had a substantial impact on our capacity to deliver care. Primary prevention was a key approach to reduce infection. Vitamin D insufficiency is highly prevalent in Canadians and worldwide. Vitamin D supplementation has been shown to significantly decrease the risk of respiratory infections. Whether this risk reduction would apply to COVID-19 infections remained to be determined. This study aimed to determine the impact of high-dose vitamin D supplementation on incidence of laboratory-confirmed COVID-19 infection rate and severity in HCWs working in high COVID incidence areas.Methods and analysisPROTECT was a triple-blind, placebo-controlled, parallel-group multicentre trial of vitamin D supplementation in HCWs. Participants were randomly allocated in a 1:1 ratio in variable block size to intervention (one oral loading dose of 100 000 IU vitamin D3+10 000 IU weekly vitamin D3) or control (identical placebo loading dose+weekly placebo). The primary outcome was the incidence of laboratory-confirmed COVID-19 infection, documented by RT-qPCR on salivary (or nasopharyngeal) specimens obtained for screening or diagnostic purposes, as well as self-obtained salivary specimens and COVID-19 seroconversion at endpoint. Secondary outcomes included disease severity; duration of COVID-19-related symptoms; COVID-19 seroconversion documented at endpoint; duration of work absenteeism; duration of unemployment support; and adverse health events. The trial was terminated prematurely, due to recruitment difficulty.Ethics and disseminationThis study involves human participants and was approved by the Research Ethics Board (REB) of the Centre hospitalier universitaire (CHU) Sainte-Justine serving as central committee for participating institutions (#MP-21-2021-3044). Participants provided written informed consent to participate in the study before taking part. Results are being disseminated to the medical community via national/international conferences and publications in peer-reviewed journals.Trial registration numberhttps://clinicaltrials.gov/ct2/show/NCT04483635.
Continuous palliative sedation in terminally ill patients with cancer: a retrospective observational cohort study from a Chinese palliative care unit
Authors: Tan Fang , Chen Shan , Huang Lan , Chen Yang , Wu Yan 
Published: May 2023

ObjectiveThis study aimed to describe a 4-year practice of continuous palliative sedation (CPS) in a palliative medicine ward of an academic hospital in China. To compare the survival time of patients with cancer with and without CPS during end-of-life care, we used the propensity score matching method and explored potential patient-related factors.DesignA retrospective observational cohort study.SettingThe palliative ward at a tertiary teaching hospital between January 2018 and 10 May 2022, in Chengdu, Sichuan, China.ParticipantsThe palliative care unit had 1445 deaths. We excluded 283 patients who were sedated on admission due to mechanical ventilation or non-invasive ventilators, 122 patients who were sedated due to epilepsy and sleep disorders, 69 patients without cancer, 26 patients who were younger than 18 years, 435 patients with end-of-life intervention when the patients’ vital signs were unstable and 5 patients with unavailable medical records. Finally, we included 505 patients with cancer who met our requirements.Main outcome measuresThe survival time and analysis of sedation potential factors between the two groups were compared.ResultsThe total prevalence of CPS was 39.7%. Patients who were sedated more commonly experienced delirium, dyspnoea, refractory existential or psychological distress, and pain. After propensity score matching, the median survival was 10 (IQR: 5–17.75) and 9 days (IQR: 4–16) with and without CPS, respectively. After matching, the two survival curves of the sedated and non-sedated groups were no different (HR 0.82; 95% CI 0.64 to 0.84; log-rank p=0.10).ConclusionsDeveloping countries also practise palliative sedation. Median survival was not different between patients who were and were not sedated.
Visual identifiers for people with dementia in hospitals: a qualitative study to unravel mechanisms of action for improving quality of care
Authors: Sutton Elizabeth , Armstrong Natalie , Locock Louise , Conroy Simon , Tarrant Carolyn 
Published: May 2023

BackgroundHospitalised people with dementia (PwD) experience worse care and more patient safety incidents than non-dementia patients. Visual identifiers are commonly used to identify patients who have a diagnosis of dementia, with the aim of promoting more personalised care. However, little is known about how they work in practice, nor about the potential unintended consequences that might arise from their use. We aim to identify the mechanisms through which visual identifiers could support good care for PwD, how and why their use may have negative consequences and the conditions for their effective use.MethodsWe conducted interviews with 21 dementia leads and healthcare professionals, 19 carers and two PwD, and produced case studies of visual identification systems in four UK acute hospital trusts between 2019 and 2021. Analysis drew on the concept of classification to identify and explore mechanisms of action.ResultsWe identified four mechanisms through which visual identifiers could help towards providing good care for PwD: enabling coordination of care at organisational level; signalling eligibility for dementia-specific interventions; informing prioritisation of resources on wards; and acting as a quick reference cue for staff. But identifier effectiveness could be undermined by: lack of standardisation and consistency; a lack of closely coupled information about individual needs; and stigma associated with a dementia diagnosis. Identifier effectiveness was dependent on their implementation being supported through staff training, resources directed and efforts to develop a supportive culture for caring for this patient group.ConclusionOur research highlights the potential mechanisms of action of visual identifiers and their possible negative consequences. Optimising the use of identifiers requires consensus on the rules of classification and the symbols used, and closely coupled patient information. Organisations need to provide support, offer the right resources and training and engage meaningfully with carers and patients about the use of identifiers.
Establishing key performance indicators for inflammatory bowel disease in the UK
Authors: Quraishi Mohammed Nabil , Dobson Elizabeth , Ainley Rachel , Din Shahida , Wakeman Ruth , Cummings Fraser , Sebastian Shaji , Bloom Stuart , Limdi Jimmy K , Dhar Anjan , Speight R Alexander , Bodger Keith , Kennedy Nicholas A ,   BSG IBD Section members, Lamb Christopher A , Arnott Ian D , Selinger Christian P 
Published: May 2023

Background and aimsHealthcare quality improvement (QI) is the systematic process to continuously improve the quality of care and outcomes for patients. The landmark Inflammatory Bowel Disease (IBD) UK National Audits provided a means to measure the variation in care, highlighting the need to define the standards of excellence in IBD care. Through a consensus approach, we aimed to establish key performance indicators (KPIs), providing reliable benchmarks for IBD care delivery in UK.MethodsKPIs that measure critical aspects of a patient journey within an IBD service were identified though stakeholder meetings. A two-stage Delphi consensus was then conducted. The first involved a multidisciplinary team of IBD clinicians and patients to refine definitions and methodology. The second stage assessed feasibility and utility of the proposed QI process by surveying gastroenterology services across UK.ResultsFirst, the four proposed KPIs were refined and included time from primary care referral to diagnosis in secondary care, time to treatment recommendation following a diagnosis, appropriate use of steroids and advanced therapies prescreening and assessment. Second, the Delphi consensus reported >85% agreement on the feasibility of local adoption of the QI process and >75% agreement on the utility of benchmarking of the KPIs.ConclusionsThrough a structured approach, we propose quantifiable KPIs for benchmarking to improve and reduce the individual variation in IBD care across the UK.
Magnetic resonance analysis of ventricular volumes in bicuspid and trileaflet aortic regurgitation
Authors: Sevilla Teresa , Rojas Gino , González-Bartol Esther , Candela Jordi , Gil José Francisco , Revilla Ana , Aristizabal-Duque Cristhian , Gomez Salvador Itziar , San Román Calvar José Alberto 
Published: May 2023

ObjectiveTo identify differences in left ventricular (LV) remodelling between patients with bicuspid aortic valve (BAV) and trileaflet aortic valve (TAV) with chronic aortic regurgitation (AR).MethodsRetrospective cohort study of 210 consecutive patients undergoing cardiac magnetic resonance for AR evaluation. We divided the study population according to valvular morphology. Independent predictors of LV enlargement AR were evaluated.ResultsThere were 110 patients with BAV and 100 patients with TAV. Patients with BAV were younger (mean age BAV vs TAV: 41±16 years vs 67±11 years; p<0.01), mostly male (% male BAV vs TAV: 84.5% vs 65%, p=0.01) and presented milder degrees of AR (median regurgitant fraction BAV vs TAV: 14 (6–28)% vs 22 (12–35)%, p=0.002). Both groups presented similar indexed LV volumes and ejection fraction. According to the degree of AR, at mild AR, patients with BAV presented larger LV volumes (BAV vs TAV: indexed end diastolic left ventricular volumes (iEDV): 96.5±19.7 vs 82.1±19.3 mL, p<0.01; indexed end systolic left ventricular volumes (iESV): 39.4±10.3 mL vs 33.2±10.5 mL, p=0.01). These differences disappeared at higher degrees of AR. Independent predictors of LV enlargement were regurgitant fraction (EDV: OR 1.118 (1.081–1.156), p<0.001; ESV: OR 1.067 (1.042–1.092), p<0.001), age (EDV: OR 0.940 (0.917–0.964), p<0.001, ESV: OR 0.962 (0.945-0.979), p<0.001) and weight (EDV: OR 1.054 (1.025–1.083), p<0.001).ConclusionsIn chronic AR, LV enlargement is an early finding. LV volumes display a direct correlation with regurgitant fraction and an inverse association with age. Patients with BAV present larger ventricular volumes, especially at mild AR. However, these differences are attributable to demographic disparities; valve type is not independently associated with LV size.