bluuebunny/crossref_metadata_2025_split huggingface dataset:
Young-onset colorectal cancer: treatment-related nausea, vomiting and diarrhoea
Authors: Mauri Gianluca , Pedrani Martino , Ghezzi Silvia , Bencardino Katia , Mariano Sara , Bonazzina Erica , Serra Francesco , Pedrazzoli Paolo , Caccialanza Riccardo , Cavestro Giulia Martina , Siena Salvatore , Artale Salvatore , Sartore-Bianchi Andrea 
Published: June 2023

ObjectivesEarly-onset colorectal cancer (EO-CRC) incidence is increasing, raising a clinical challenge. Clinicians tend to treat EO-CRC patients with more intensive regimens despite the lack of survival benefits, based on an age-related bias. Limited evidence is available regarding treatment-related toxicities in this peculiar subset of patients.MethodsWe performed a literature search in MEDLINE/PubMed, EMBASE and Scopus, looking for reporting of nausea, vomiting and diarrhoea occurring in patients with EO-CRC, defined by age lower than 50 years old at initial diagnosis, while receiving anticancer treatment.Results2318 records were screened and 9 full-text articles were considered eligible for inclusion for a total of 59 783 patients (of whom 8681 EO-CRC patients). We found nausea and vomiting occurring at higher incidence among EO-CRC compared with older patients, while no difference was reported as for diarrhoea. Peritoneal involvement, age younger than 40, female gender, suboptimal adherence to guidelines and oxaliplatin might represent potential risk factors for increased nausea and vomiting in patients with EO-CRC.ConclusionEO-CRC patients experience more nausea and vomiting but equal or less diarrhoea compared with older patients. Adherence to clinical guidelines is recommended, and more data are warranted to assess if an enhanced antiemetic approach might be required, particularly in case of specific risk factors.
Comparison of Kaltenborn mobilization technique and muscle energy technique on range of motion, pain and function in subjects with chronic shoulder adhesive capsulitis
Authors: Pattnaik Sandeep , Kumar Pravin , Sarkar Bibhuti , Oraon Anil Kumar 
Published: June 2023

Background: Shoulder adhesive capsulitis (AC) is a common musculoskeletal condition causing pain, loss of range of motion (ROM) in the shoulder, and a decrease in its functionality, yet poorly defined and understood since its identification. Kaltenborn mobilization technique (KMT) and muscle energy technique (MET) are commonly used physiotherapeutic techniques for their treatment. To the best of our understanding, there was no study found to compare the effectiveness of one technique over another. Objective: The objective of this study was to compare the effectiveness of KMT and MET on the ROM, pain and function in subjects with chronic shoulder AC. Methods: In this single-centred, single-blinded quasi-experimental study with a pretest–posttest design 35 subjects were randomized into two groups: Group A ([Formula: see text]) received KMT and Group B ([Formula: see text]) received MET along with the moist hot pack (MHP), supervised exercises and home exercises common to both the groups. A total of 32 subjects completed the study with three dropouts. Subjects were evaluated before and after 10 treatment sessions for the outcomes, shoulder external rotation passive range of motion (ER-PROM) and abduction passive range of motion (ABD-PROM) using the universal goniometer, intensity of pain using the numeric pain rating scale (NPRS) and functional disability using the shoulder pain and disability index (SPADI). Results: Analysis of 32 subjects showed that both groups were homogenous at baseline. The within-group analysis showed significant improvement ([Formula: see text]) in both groups related to all the outcomes. But when we compared the groups, Group B showed significant ([Formula: see text]) improvement in NPRS and SPADI in comparison to Group A. However, there was non-significant ([Formula: see text]) difference found in ER-PROM and ABD-PROM. Conclusion: Both KMT and MET are effective in improving ROM, pain and function but MET showed a significant reduction of pain and improvement in function in subjects with chronic shoulder AC, thus supporting its use as a physiotherapeutic treatment technique.
Organic nanomaterials from self-assembly of BODIPY-benzothiadiazole conjugate for PDT/PTT synergistic therapy
Authors: Sha Qilong , Deng Jingran , Zhang Huishuang , Luo Xiaogang , Wu Fengshou 
Published: June 2023

Near-infrared light-induced phototherapy including photothermal therapy (PTT) and photodynamic therapy (PDT) has emerged as a new noninvasive method for cancer treatment owing to the nature of high efficiency and spatiotemporal selectivity. In this study, a new boron-dipyrromethene (BODIPY) molecule (BDP-BT) with donor (D)-receptor (A)-donor (D) structure was designed and successfully synthesized by conjugation of benzothiadiazole (BT) with BODIPY structure. The polyethylene glycol chain (PEG) was modified onto the meso site of BODIPY to improve the hydrophilicity and biocompatibility of the compound. The amphiphilic BDP-BT was then self-assembled into nanoparticles (BDP-BT NPs) with red-shifted absorption and enhanced hydrophilicity. BDP-BT NPs can produce effective reactive oxygen species and local hyperthermia triggered by a single laser. The in vitro experiments revealed that BDP-BT NPs had good biocompatibility and remarkable photocytoxicity. The half maximal inhibitory concentration (IC[Formula: see text] of BDP-BT NPs was valued at 22.17 [Formula: see text]g/mL under 635 nm laser irradiation. Furthermore, BDP-BT NPs can efficiently generate reactive oxygen species (ROS) in the tumor cells under light irradiation. Thus, the as-prepared BDP-BT NPs could be used as promising agents for PDT and PTT synergistic cancer therapy.
Impact of cover crops on population density of the root-knot nematode Meloidogyne chitwoodi
Authors: Taning Lirette M. , Tafes Eleni K. , Fleerakkers Sander , Lippens Louis , Formesyn Ellen , Tirry Luc , Wesemael Wim M.L. 
Published: June 2023

Summary
Management strategies applied to reduce Meloidogyne chitwoodi populations below economic damage threshold depend strongly on measures taken during the intercrop period. Therefore, this study evaluated the reproductive potentials of M. chitwoodi on different cultivars of cover crops. Twenty-two different cultivars were evaluated against M. chitwoodi at low and high initial inoculum density in a pot experiment under controlled conditions. Fallow was used as control. Based on the reproductive factor, the cover crops were classified under five different categories: Non-host, Poor host, Maintenance host, Good host and Excellent host. In this study, at both low (10 second-stage juveniles (J2) 100 cm−3 soil) and high (100 J2 100 cm−3 soil) initial inoculum density of M. chitwoodi, fodder radish ‘Maximus’, ‘Contra’, ‘Dacapo’ and ‘Defender’, Italian ryegrass ‘Meroa’, rye ‘Matador’ and bird’s foot trefoil ‘Barguay’, ‘Franco’ and ‘Lotar’ were considered poor hosts reducing the M. chitwoodi population in the pot test based on reproductive factor (RF) values. Field experiments were carried out that confirmed most of our results in the pot experiments. However, the field experiments showed that the rotations in which the cover crops are implemented are influenced by weather conditions, previous crop grown, their growing period and initial population densities. Based on our findings, selected non- and poor-host cover crops could be recommended for integrated management of M. chitwoodi.
On the Orientalism of Dana Logan’s Awkward Rituals
Authors: Geslani Marko 
Published: June 2023

Abstract
This article assesses the merits of Dana Logan’s Awkward Rituals as a notable anthropological intervention in the study of American religions, one that opens significant converse with Asian ritual traditions, as mediated by colonial history. It suggests that the book presents a genealogically measured theoretical advance to the tradition of ritual studies.
Urartian Stelae in Late Antique and Early Medieval Armenia
Authors: Rojas Felipe 
Published: June 2023

Abstract
This article concerns how Armenian communities throughout the 1st millennium A.D. reinterpreted and redeployed cuneiform inscriptions originally carved in the Iron Age as meaningful traces of the local past. It focuses on the deliberate re-use by early Armenian Christians of Iron-Age stelae bearing Urartian cuneiform inscriptions in the region around Lake Van. Scholars have noted such re-use in passing since the 19th century A.D., but there has been no concerted effort to collect or interpret relevant evidence holistically. The article distinguishes several distinct trends in Armenian engagements with cuneiform (and hieroglyphic) inscriptions in their native territories over the course of the 1st millennium A.D. Combining literary and archaeological evidence, it contextualizes cases of re-use as clashes of historical consciousness, expressed via material culture, in dynamic situations of colonial contact and religious conversion.
Traditionalism and Demodernisation
Authors: Andreyev Sergei 
Published: June 2023

Abstract
With the beginning of a partial modernisation in Afghanistan in the late 19th century there emerged a pattern of opposition to this process. Often described as traditionalism it aimed not only at the maintaining of the status quo but had a demodernising twist seeking the establishment of an alternative socio-political order pursuing demodernisation dressed in traditionalist Islamic or tribal rhetoric but undermining the traditional modus vivendi by introducing political tools and institutions specifically promoting demodernisation. There are three parallel tracks in the development of actors opposing modernisation, viz., the traditionalist ones (tribes and Islamic clerics), conscious demodernisers (Bachah-ye Saqao Emirate in 1929 and the Taliban), and forces of political Islam that fit the modernisation paradigm but deliver on the demodernisation agenda (Islamist political parties cum armed movements of the 1970–1980s). The background of these three modernisation-opposing forces and the time and place specific circumstances of their operational environment explain the particular ideological and political track they were taking. Their alternating use of opposing tribal and Islamic institutions in promoting their agendas adds to the understanding of their peculiarities. Counter-modernisation activities may derive from different premises, where deliberate demodernisation and that as a by-product of modernised political endeavours are of theoretical interest.
Muḥammad in Zion
Authors: Hussein Mostafa 
Published: June 2023

Abstract
This article discusses the ways in which Hebrew writers in late Ottoman and Mandatory Palestine interacted with the history of early Islam and the relations between Muslims and Jews of the Arabian Peninsula and the political, cultural, and social functions their reconstruction fulfilled in the critical junctures of Hebrew culture in the East. The article argues that these Hebrew works reflected the development of Hebrew culture in Palestine and masqueraded the advancement of Zionist tenants among Jewish settlers on the land. Those Zionist ideals encompassed: the revival of Hebrew, the physical and cultural return to the Orient, the demonstration of the cultural and material profits Zionists might bring to the indigenous population of Palestine through underscoring a Jewish influence on Islam, and finally, to promote aspects of Jewish heroism and sacrifice by focusing on the early confrontation between Jews and Muslims.
Competing Forecast Verification: Using the Power-Divergence Statistic for Testing the Frequency of “Better”
Authors: Gilleland Eric , Muñoz-Esparza Domingo , Turner David D. 
Published: June 2023

Abstract
When testing hypotheses about which of two competing models is better, say A and B, the difference is often not significant. An alternative, complementary approach, is to measure how often model A is better than model B regardless of how slight or large the difference. The hypothesis concerns whether or not the percentage of time that model A is better than model B is larger than 50%. One generalized test statistic that can be used is the power-divergence test, which encompasses many familiar goodness-of-fit test statistics, such as the loglikelihood-ratio and Pearson X2 tests. Theoretical results justify using the distribution for the entire family of test statistics, where k is the number of categories. However, these results assume that the underlying data are independent and identically distributed, which is often violated. Empirical results demonstrate that the reduction to two categories (i.e., model A is better than model B versus model B is better than A) results in a test that is reasonably robust to even severe departures from temporal independence, as well as contemporaneous correlation. The test is demonstrated on two different example verification sets: 6-h forecasts of eddy dissipation rate (m2/3 s−1) from two versions of the Graphical Turbulence Guidance model and for 12-h forecasts of 2-m temperature (°C) and 10-m wind speed (m s−1) from two versions of the High-Resolution Rapid Refresh model. The novelty of this paper is in demonstrating the utility of the power-divergence statistic in the face of temporally dependent data, as well as the emphasis on testing for the “frequency-of-better” alongside more traditional measures.
Fatal Atractylis gummifera L. poisoning: A case report of an autopsy
Authors: Khanfri Leila , Madi Aya , Hajji Hafsa , Naji Salma , E El Kettani Salma , Boughima Fadila A 
Published: June 2023

Atractylis gummifera L. is a wild poisonous plant found in rural areas around the Mediterranean. It is also available from herbalists. This plant has a liver tropism which can be fatal whether taken orally or transcutaneously. In this case report, we report and discuss the clinical, biological and autopsy data of one case of poisoning of a small child in Morocco with a view to raising awareness of this dangerous poisonous glue thistle especially when used transcutaneously.
Electrocardiographic frontal QRS-T angle is independently associated with panic disorder
Authors: Yılmaz Mücahid , Yılmaz Seda 
Published: June 2023

Objective Panic disorder (PD) may cause serious cardiac arrhythmias by causing electrical abnormalities. Abnormal P-wave axis (aPwa), presence of fragmented QRS (fQRS), wide frontal QRS-T angle (fQRSTa), QRS duration corrected (QRSdc) and log/ logQRS duration/RR interval (log/logQRS/RR) have been correlated with increased risk of serious supraventricular and ventricular cardiac arrhythmias in a general population. The purpose of this study was to compare these newly explored atrial and ventricular arrhythmia indicators in patients with PD and in healthy subjects. Method A total of 169 newly diagnosed PD patients and 128 healthy subjects were included in the study. The Panic and Agoraphobia Scale (PAS) was administered, and 12-lead electrocardiography (ECG) measurements were obtained. Electrocardiographic parameters including aPwa, fQRSTa, presence of fQRS, QRS duration corrected (QRSdc), and log/logQRS duration/RR distance (log/logQRS/RR) were compared between the two groups. Results aPwa and fQRS, in addition to fQRSTa, QRSdc, and log/ logQRS/RR ratio values, were significantly increased in the PD group compared to healthy controls. Correlation analyses revealed that wider fQRSTa, number of fQRS derivation, number of total fQRS, wider QRSdc, and log/logQRS/RR ratio significantly correlated with PAS score. Logistic regression analysis demonstrated that fQRSTa and the number of total fQRS were independently associated with PD. Conclusion PD is associated with wider fQRSTa, QRSdc, and log/logQRS/RR in addition to the increased abnormal aPwa and presence of fQRS. These findings suggest that untreated PD patients may be susceptible to supraventricular and ventricular arrhythmia, indicating that ECG should be routinely obtained in the management of PD patients.
Red blood cell distribution width predicts mortality of adult patients receiving veno-arterial extracorporeal membrane oxygenation
Authors: Lu Shu Y , Ortoleva Jamel , Colon Katia , Mueller Ariel , Laflam Andrew , Shelton Kenneth , Dalia Adam A 
Published: June 2023

Background Red blood cell distribution width (RDW) is a numerical measure of the variation in the size of circulating red blood cells. Recently, there is increasing interest in the role of RDW as a biomarker for inflammatory states and as a prognostication tool for a wide range of clinical manifestations. The predictive power of RDW on mortality among patients receiving mechanical circulatory support remains largely unknown. Methods A retrospective analysis of 281 VA-ECMO patients at a tertiary referral academic hospital from 2009 to 2019 was performed. RDW was dichotomized with RDW-Low <14.5% and RDW-High ≥14.5%. The primary outcome was all-cause mortality at 30 days and 1 year. Cox proportional hazards models were used to examine the association between RDW and the clinical outcomes after adjusting for additional confounders. Results 281 patients were included in the analysis. There were 121 patients (43%) in the RDW-Low group and 160 patients (57%) in the RDW-High group. Survival to ECMO decannulation [RDW-H: 58% versus RDW-L: 67%, p = 0.07] were similar between the two groups. Patients in RDW-H group had higher 30-days mortality (RDW-H: 67.5% vs RDW-L: 39.7%, p < 0.001) and 1 year mortality (RDW-H: 79.4% vs RDW-L: 52.9%, p < 0.001) compared to patients in the RDW-L group. After adjusting for confounders, Cox proportional hazards model demonstrated that patients with high RDW had increased odds of mortality at 30 days (hazard ratio 1.9, 95% CI 1.2–3.0, p < 0.01) and 1 year (hazard ratio 1.9, 95% CI 1.3–2.8, p < 0.01) compared to patients with low RDW. Conclusions Among patients receiving mechanical circulatory support with VA-ECMO, a higher RDW was independently associated with increased 30-days and 1-year mortality. RDW may serve as a simple biomarker that can be quickly obtained to help provide risk stratification and predict survival for patients receiving VA-ECMO.
Pulmonary comorbidities in psoriasis are associated with a high risk of respiratory failure
Authors: Tanimura Kazuya , Nouraie Seyed Mehdi , Chandra Divay , Nyunoya Toru 
Published: June 2023

Objectives To identify respiratory comorbidities associated with a high risk of developing respiratory failure in subjects with psoriasis. Methods This was a cross-sectional analysis of data from subjects enrolled in the UK Biobank cohort. All diagnoses were self-reported. The risk of each respiratory comorbidity was compared by logistic regression models adjusting for age, sex, weight, diabetes mellitus, and smoking history; the risk of comorbid respiratory failure for each pulmonary comorbidity was also compared. Results Of the 472,782 Caucasian subjects in the database, 3,285 self-reported a diagnosis of psoriasis. More men and smokers reported psoriasis and were older, had higher weight and body mass index, and lower pulmonary function than non-psoriatic subjects. Those with psoriasis were at significantly higher risk for multiple pulmonary comorbidities compared to those without psoriasis. Furthermore, those with psoriasis had a higher risk for respiratory failure accompanied by asthma and airflow limitation than non-psoriatic subjects. Conclusions Subjects with psoriasis and pulmonary comorbidities, such as asthma and airflow limitation, are at increased risk for respiratory failure. Common immunopathological links implicating a ‘skin-lung axis’ may underlie psoriasis and pulmonary comorbidities.
Operationalising Strong Sustainability: Definitions, Methodologies and Outcomes
Authors: Özkaynak Begüm , Devine Pat , Rigby Dan 
Published: June 2023

While acknowledging the absence of a single definition or theory of sustainability, this paper argues that a discussion of sustainability which refers only to definitions is pointless without an understanding of how the definitions are operationalised. In this context, the paper considers the operationalisation of strong sustainability. The definitions and operationalisation of strong sustainability most closely associated with (i) neoclassical environmental economics and (ii) ecological economics are discussed and compared. This analysis raises questions about the extent to which ecological economics has been able to influence real-world decisions and policy. The paper ends by considering whether the economic and political power structure taken as given by ecological economics is compatible with its policy perspective.
Sustentaculum tali in Chinese population: anatomy and clinical significance
Authors: Liao Li-Qing , Feng Zi-Yu , Yang Han , Li Yi-Kai 
Published: June 2023

Background Previous studies lacked adequate quantitative data on sustentaculum tali (ST), especially in Chinese population. The aims of this study are to explore the quantitative morphology of ST in dried bone specimens, and to discuss its implications related to ST screw fixation, talar articular facet variation, as well as subtalar coalitions. Methods A total of 965 dried intact calcanei from Chinese adult donors were evaluated. All linear parameters were measured by two observers with a digital sliding vernier caliper. Results Most parts of ST body can accommodate a commonly-used 4-mm-diameter screw, but the minimum height of anterior ST is only 4.02 mm. The shapes of the STs are slightly affected by left-right, subtalar facet, but the subtalar coalition may potentially increase the sizes of STs. The incidence of tarsal coalition is 14.09%. Among the osseous connection, there are 58.8% of type A articular surface and 76.5% of middle and posterior talar facet (MTF and PTF) involvement. ROC curve shows that subtalar coalition will be detected when ST length is greater than 16.815 mm. Conclusions Theoretically, all the STs can accommodate 4 mm diameter screw, but a 3.5 mm diameter screw is recommended to be placed in the middle or posterior of the small ST for safety. The shapes of the STs are greatly influenced by the subtalar coalition, while they are less affected by left-right, subtalar facet. The osseous connection is common in type A articular surface and always involved in the MTF and PTF. The cut-off value of the length of STs was confirmed as 16.815 mm for predicting subtalar coalition.
Functional Near-Infrared Spectroscopy of English-Speaking Adults With Attention-Deficit/Hyperactivity Disorder During a Verbal Fluency Task
Authors: Husain Syeda Fabeha , Chiang Soon Kiat , Vasu Aveline Ajalan , Goh Claire P. , McIntyre Roger S. , Tang Tong Boon , Tran Bach X. , Dang Trang H.T. , Nguyen Tham T. , Ho Roger C. , Ho Cyrus S. 
Published: June 2023

Objective: Functional near-infrared spectroscopy (fNIRS) provides direct and quantitative assessment of cortical hemodynamic response. It has been used to identify neurophysiological alterations in medication-naïve adults with attention-deficit/hyperactivity disorder (ADHD). Hence, this study aimed to distinguish both medication-naïve and medicated adults with ADHD from healthy controls (HC). Method: 75 HCs, 75 medication-naïve, and 45 medicated patients took part in this study. fNIRS signals during a verbal fluency task (VFT) were acquired using a 52-channel system and relative oxy-hemoglobin changes in the prefrontal cortex were quantified. Results: Prefrontal cortex hemodynamic response was lower in patients than HCs (p ≤ ≤.001). Medication-naïve and medicated patients did not differ in hemodynamic response or symptom severity (p > .05). fNIRS measurements were not associated with any clinical variables (p > .05). 75.8% patients and 76% HCs were correctly classified using hemodynamic response. Conclusion: fNIRS may be a potential diagnostic tool for adult ADHD. These findings need to be replicated in larger validation studies.