bluuebunny/crossref_metadata_2025_split huggingface dataset:
A solution method for nonlinear monotone equations via hybrid spectral conjugate gradient and signal recovery problems
Authors: Yusuf Aliyu , Manjak Nibron Haggai , Mohammad Hassan , Kiri Aliyu Ibrahim , Abubakar Auwal Bala 
Published: July 2023

Abstract

In this paper, we propose a solution method via hybrid spectral conjugate gradient and signal recovery problem (ANHSCG) to solve nonlinear monotone equations. This has been done using the hybrid conjugate gradient (CG) parameters of Dai-Yuan (DY), conjugate descent (CD), Hestenes-Stiefel (HS), Liu-Storey (LS) and the corresponding search direction of spectral conjugate gradient method. The search direction has proved to be adequately descent regardless of the step-size. Under reasonable assumptions, the convergence of the algorithm is established. Additionally, numerical tests are run on a set of benchmark test problems to illustrate the effectiveness and competitiveness of the new algorithm compared with other existing alternatives. Finally, some applications of the proposed algorithm is explored.
Mathematics Subject Classification: 65K05, 90C52, 90C26
UV-B induced HSV-1 reactivation leads to infectious virus in the corneas of virtually all latently infected mice and requires an intact STING to develop herpetic stromal keratitis
Authors: Yin Xiao-Tang , Hartman Alexis , Sirajuddin Nadia , Shukla Deepak , Leger Anthony St. , Keadle Tammie L. , Stuart Patrick M. 
Published: July 2023

Abstract
Reactivation of latent herpes simplex type 1 results in virus returning to the cornea leading to recurrent herpetic stromal keratitis (rHSK). We compare two competing models to reactivate viruses from latency, UV-B irradiation and cyclophosphamide. Results revealed that while both result in corneal recrudescence, only UV-B irradiation results in rHSK. To better understand the dynamics of reactivation, we analyzed corneas for both the presence of infectious viruses and the dynamics of exposure to multiple reactivations using UV-B. We noted that multiple reactivations result in progressively worse corneal disease. We also noted that expression of IFNα and STING, surragate markers for the presence of virus, are induced by the presence of reactivated virus. Studies to determine the importance of STING to the development of HSK revealed that in the absence of STING, mice do not develop significant HSK and the magnitude of the infiltrate of CD45 + cells in these corneas is significantly reduced. The resulting paucity of CD45 + CD11b + GR-1 + F4/80-neutrophils, and to a lesser extent CD45 + CD11b + GR-1-F4/80 + macrophages in B6-STING KO mice following reactivation is likely the underlying cause for lack of rHSK as has been noted by ourselves and others. These results underscore the critical importance of STING’s role in developing rHSK.
Application and evaluation of classic and demand oriented cooling strategies in context of machine tools
Authors: Wenkler Eric , Steiert Christoph , Ihlenfeldt Steffen , Weber Jürgen 
Published: July 2023

Abstract
Energy consumption is an important factor in the operation of machine tools
Recent studies showed that in average 1/5 of the machine tools total energy demand is caused by internal cooling systems.
The continually rising performance of machine tools together with the importance of thermal stability, reasons the requirement for demand oriented cooling approaches, which could significantly reduce the energy consumption for internal machine cooling.
This study applied classic and demand oriented cooling strategies on a machine tool frame, which is one of the most complex machine tool components from a thermal point of view.
The demand oriented cooling is based on volume flow control and can either be configured close to the environmental temperature or close to the thermal steady state, which can be obtained by loss forecast in combination with an FE-Model or measurement.
The impact of the strategies on the thermal reaction as well as the energy consumption is compared, showing a significant reduction of energy demand without significant impairment of the thermal stability.
Economic and clinical burden in patients with primary hyperoxaluria treated with dialysis: A real- world evidence study in the United States
Authors: Fazio-Eynullayeva Elnara , Karafilidis John , Chen Herman , Brown Jeffrey S. 
Published: July 2023

Abstract
Background: Primary hyperoxaluria (PH) is a family of rare genetic disorders characterized by dysregulation of glyoxylate metabolism. PH is associated with nephrocalcinosis and chronic kidney disease, which often requires dialysis treatment and organ transplant as the disease progresses to end-stage kidney disease. Limited patient data resulting from low incidence rates and diagnostic challenges associated with PH have prevented adequate characterization of the economic and clinical burden of the disorder. This study examined demographic characteristics, clinical markers, and healthcare utilization of dialysis-treated patients with PH.
Methods: This real-world retrospective study analyzed data from the TriNetX Dataworks USA Network from October 1, 2018, to February 2, 2021. The study cohort comprised of patients with a PH diagnosis who initiated dialysis during the study period. Demographics, clinical markers, and healthcare utilization were captured during the baseline period before initiating the first dialysis and during follow-up. Clinical disease progression was assessed via eGFR measurements and the number of kidney stone events (KSE).
Results: A total of 47 patients with PH were eligible for this analysis, of whom just 46.8% received a clinical diagnosis of PH before initiating dialysis. The mean age of the cohort was 58.7 years, and the majority of patients were female (53.2%), White (85.1%), and non-Hispanic/Latino (78.7%). The mean value of the earliest eGFR measurement was 27.2 mL/min, and 42.6% of patients had documented acute renal insufficiency during the baseline period. KSEs were highest in the baseline period immediately preceding dialysis initiation. Healthcare costs within the 12 months preceding and the 12 months following dialysis initiation were a mean of $150,346 and $217,784, respectively.
Conclusions: A delayed diagnosis was common among patients with PH, with over half of the cohort receiving their diagnosis after commencing dialysis. Patients with PH are burdened with high healthcare costs and complicated care pathways up to and following the first instance of dialysis. Future research focusing on strategies to improve health outcomes and address the financial burden associated with PH is warranted.
Replicability and reproducibility of predictive models for diagnosis of depression among young adults using Electronic Health Records
Authors: Nickson David , Singmann Henrik , Meyer Caroline , Toro Carla , Walasek Lukasz 
Published: July 2023

Abstract
Background
Recent advances in machine learning combined with the growing availability of digitized health records offer new opportunities for improving early diagnosis of depression. An emerging body of research shows that Electronic Health Records can be used to accurately predict cases of depression on the basis of individual’s primary care records. The successes of these studies are undeniable, but there is a growing concern that their results may not be replicable, which could cast doubt on their clinical usefulness.
Methods
To address this issue in the present paper, we set out to reproduce and replicate the work by Nichols et al. (2018), who trained predictive models of depression among young adults using Electronic Healthcare Records. Our contribution consists of three parts. First, we attempt to replicate the methodology used by the original authors, acquiring the same set of primary health records and reproducing their data processing and analysis. Second, we test models presented in the original paper on our own data, thus providing out of sample prediction of the predictive models. Third, we extend past work by considering several novel machine learning approaches in an attempt to improve the predictive accuracy achieved in the original work.
Results
In summary, our results demonstrate that the work of Nichols et al. is largely reproducible and replicable. This was the case both for the replication of the original model and the out of sample replication applying NRCBM coefficients to our new EHRs data. Although alternative predictive models did not improve model performance over standard logistic regression, our results indicate that stepwise variable selection is not stable even in the case of large data sets.
Conclusion
We discuss the challenges associated with the research on mental health and Electronic Health Records, including the need to produce interpretable and robust models. We demonstrated some potential issues associated with the reliance on EHRs, including changes in the regulations and guidelines (such as the QOF guidelines in the UK) and reliance on visits to GP as a predictor of specific disorders.
Analysis of bacterial spectrum and drug sensitivity in preoperative urine culture of upper urinary calculi
Authors: zhao changyuan 
Published: July 2023

Abstract
OBJECTIVE:
To analyze the distribution of urinary culture pathogenic bacteria and drug resistance in patients with upper urinary calculi combined with urinary tract infections.
METHODS:
Seventy-three patients with upper urinary calculi combined with urinary tract infection who were hospitalized in Taikang Xianlin Drum Tower Hospital from January 2020 to April 2023 were retrospectively analyzed as study subjects. The patients' midstream urine samples was collected in morning, and urine culture and drug sensitivity tests were performed to analyze their pathogenic bacteria distribution and drug resistance.
Results:
In the urine specimens of 73 patients with upper urinary calculi, 80 pathogenic bacteria were detected, including 52 were Gram-negative bacteria (65.00%), 23 were Gram-positive bacteria (28.75%) and 5 were fungi (6.25%). Gram-negative bacteria were mainly Escherichia coli, Gram-positive bacteria were mainly Enterococcus faecalis, and fungi were mainly candida albicans; the top 10 drugs in terms of sensitivity to Gram-negative bacteria were imipenem(100.00%), cefoperazone/sulbactam(100.00%), meropenem (100.00%), amikacin(98.04%), piperacillin/tazobactam (96.08%), cefotetan(93.62%), Nitrofurantoin(84.85%), cefepime(84.44%), aztreonam(81.63%), and tobramycin(76.92%). The top three drug resistance rates were ampicillin(84.62%), piperacillin(56.86%), and ampicillin/sulbactam(46.15%). The drugs with high sensitivity rates to gram-positive bacteria were vancomycin(100%), linezolid(100%), tigecycline(100%), Nitrofurantoin (94%), ampicillin(83%), and penicillin G(79%).
CONCLUSION:
Gram-negative and Gram-positive bacteria are the main pathogens of urinary tract infections in patients with upper urinary calculi, and their major strains differ in their resistance to commonly used antimicrobial drugs.
Influence of Non-Homogeneity, Rotation, Magnetic Field, and Initial Stress on Radial Vibrations in Thermo-Viscoelastic Isotropic Media
Authors: Balubaid Mohammed A. 
Published: July 2023

Abstract
This paper presents an innovative analytical approach to investigate the effects of rotation and initial stress on a magneto-thermo-viscoelastic non-homogeneous medium with a spherical cavity under periodic loading. The study focuses on analyzing the distribution of displacements, temperature, and stresses within the non-homogeneous medium using the generalized thermoelasticity framework based on the GL theory. The derived analytical solutions are extensively discussed, and the results are visually presented to illustrate the influences of rotation, initial stress, relaxation times, magnetic field, viscoelasticity, and non-homogeneity. Furthermore, comprehensive comparisons with prior research are conducted, encompassing scenarios with and without rotation, magnetic field, and initial stress. These comparisons contribute to establishing the significance of the findings and highlight the advancements made in this study in relation to existing knowledge in the field.
MSC: 74F15, 74H45, 74J20, 74K10
Association between mammillary body atrophy and memory impairment in retired athletes with a history of repetitive mild traumatic brain injury
Authors: Miyata Mari , Takahata Keisuke , Sano Yasunori , Yamamoto Yasuharu , Kurose Shin , Kubota Manabu , Endo Hironobu , Matsuoka Kiwamu , Tagai Kenji , Oya Masaki , Hirata Kosei , Saito Fumie , Mimura Masaru , Kamagata Koji , Aoki Shigeki , Higuchi Makoto 
Published: July 2023

Abstract
Cognitive dysfunction, especially memory impairment, is a typical clinical feature of long-term symptoms caused by repetitive mild traumatic brain injury (rmTBI). The current study aims to investigate the relationship between regional brain atrophy and cognitive impairments in retired athletes with a long history of rmTBI. Overall, 27 retired athletes with a history of rmTBI (18 boxers, 3 kickboxers, 2 wrestlers, and 4 others; rmTBI group) and 23 age/sex-matched healthy participants (control group) were enrolled. MPRAGE on 3T MRI was acquired and segmented. The total brain volume (TBV) and regional brain volumes of the mammillary bodies (MBs), hippocampi, amygdalae, thalami, caudate nuclei, and corpus callosum (CC) were estimated using the SPM12 and ITK–SNAP tools. The rmTBI group underwent neuropsychological tests for verbal and visual memory, attention, executive function, and global cognitive function. TBV and TBV-adjusted regional brain volumes were compared between rmTBI and control participants using the Mann-Whitney U test. Furthermore, we assessed the relationship of the memory test to TBV and TBV-adjusted regional brain volumes by the Spearman’s rank correlation coefficient. The TBV and TBV–adjusted regional brain volumes were compared between groups, and the relationship between the neuropsychological test scores and the regional brain volumes were evaluated. Compared with the control group, the rmTBI group showed significantly lower MBs volume/TBV ratio (0.13 ± 0.05 vs. 0.19 ± 0.03 ×10− 3, p < 0.05) and The CC volume/TBV ratio (12.5 ± 1.63 vs. 13.6 ± 1.81 ×10− 3, p < 0.05). The MBs volume/TBV ratio correlated with visual and verbal memory, as assessed, respectively, by the Rey–Osterrieth Complex Figure test delayed recall (ρ = 0.48, p < 0.05) and logical memory delayed recall (ρ = 0.41, p < 0.05). The CC volume/TBV ratio didn’t correlate with any cognitive assessment result (p > 0.05). MB disconnection from the Papez circuit is associated with memory impairment in retired athletes with rmTBI.
Preliminary evaluation of the clinical efficacy of salmon calcitonin nasal spray in patients with rotator cuff tears after arthroscopic repair: a retrospective study
Authors: Lyu Fei , Du Jianwei , Li Jianan , Wu Yafei , Xu Zheng , Shi Dai 
Published: July 2023

Abstract
Background Rotator cuff tears (RCTs) are the most common shoulder disorder, which can be effectively treated by arthroscopic technique. However, the re-tear rates following rotator cuff repair range from 10% in small tears to 91% in massive tears, leading to a failure of healing, particularly in patients with osteoporosis or acute bone loss. Calcitonin used for acute bone loss has currently become a consensus. This study aims to assess the efficacy of salmon calcitonin nasal spray (SCNS) in patients with RCTs after arthroscopic repair.
Methods It was a retrospective study which involved patients affected by RCTs from January 2018 to December 2019. All of the patients accepted arthroscopic surgery and were divided into two groups, with or without use of SCNS after the surgery. Patients were evaluated with clinical examination, pain scores based on visual analog scale (VAS) and functional outcomes based on the Constant-Murley shoulder score (CMS) and simple shoulder test (SST) before surgery, at 3, 6, and 24 months after surgery.
Results Groups 1 (control group) and 2 (study group) comprised 26 and 29 patients, respectively, who showed no significant differences in demographic characteristics (p>0.05). In general, the mean ± sd of patient age was 52.27 ± 8.53 years (range, 39–75 years). Among the patients, 28 (50.9%) were male, and 27 (49.1%) were female. Shoulder function (CMS, SST) improved over time in both groups (p<0.05). At 3 months, VAS, CMS and SST values in study group were superior to those in control group (p<0.05). However, this trend was not persisted at 6 and 24 months. Tendon re-tear was seen in two of the patients in control group, but there was no significant difference in re-tear rates in the two groups (p=0.219). No other post-surgical complication was found in either group.
Conclusions Use of SCNS could significantly reduce postoperative pain level and improve shoulder function in the early stage after arthroscopic repair, but it could not decrease the rotator cuff re-tear rate. Prospective studies involving large samples are required to observe the long term effects further more.
Bilateral inguinal hernia repair by laparoscopic totally extraperitoneal (TEP) vs. laparoscopic transabdominal preperitoneal (TAPP)
Authors: Hidalgo Nils Jimmy , Guillaumes Salvador , Bachero Irene , Butori Eugenia , Espert Juan José , Ginestà César , Vidal Óscar , Momblán Dulce 
Published: July 2023

Abstract
Background: The guidelines recommend laparoscopic repair for bilateral inguinal hernia. However, few studies compare the totally extraperitoneal (TEP) and transabdominal preperitoneal (TAPP) techniques in bilateral inguinal hernia. This study aimed to compare the outcomes of TEP and TAPP in bilateral inguinal hernia.
Methods: We conducted a retrospective cohort study of patients operated on for bilateral inguinal hernia by TEP and TAPP repair from 2016 to 2020. Intraoperative complications, operative time, acute postoperative pain, hospital stay, postoperative complications, chronic inguinal pain, and recurrence were compared.
Results: A total of 155 patients were included in the study. TEP was performed in 71 patients (46%) and TAPP in 84 patients (54%). The mean operative time was longer in the TAPP group than in the TEP group (107 min vs. 82 min, p<0.001). The conversion rate to open surgery was higher in the TEP group than in the TAPP group (8.5% vs. 0%, p=0.008). The mean hospital stay was longer in the TAPP group than in the TEP group (p<0.001). We did not observe significant differences in the proportion of postoperative complications(p=0.672), postoperative pain at 24 hours (p=0.851), chronic groin pain (p=0.593), and recurrence (p=0.471). We did not observe an association between the choice of surgical technique (TEP vs. TAPP) with postoperative complications, chronic inguinal pain, or hernia recurrence; when performing a multivariable analysis adjusted for the male sex, age ≥65 years, BMI ≥30, ASA II-IV, recurrent hernia repair, and hernia size >3cm.
Conclusions: We did not find significant differences in postoperative complications, acute postoperative pain, chronic inguinal pain, and recurrence. Operative time and hospital stay were longer in TAPP, while TEP conversion to open surgery was higher.
Study on Wild Edible Plant Used by Shinasha Ethnic Community at Metekel Zone, Northwest Ethiopia
Authors: Birhanu Abesh 
Published: July 2023

Abstract
Wild edible plants are an essential source of supplementary foods in many parts of Ethiopia. The aims of this study were to record and document wild edible plants used by shinasha ethnic community in Metekele Zone Northwestern Ethiopia. The Field surveys were conducted from Jun to Dec, 2022. Semi-structured interview, direct observation, focus group discussion, guided fled walks, and market surveys were used to collect data. A total of 120 informants were participated in interviewed. Descriptive statistical was made to analyze the data using SPSS version.20. A total 46 wild edible plants belonging to 38 genera and 30 families were recorded. Family Moraceae were the most popular edible plant. Trees were the dominant life forms (36.9%) and ripe fruits (58.6%) recorded plants par used in study area. The majority of (14 specie) were collected from natural forest followed by riverine banks habitat (12species). The majority of wild edible plants are mainly harvested and consumed during autumn followed by summer season. Based on the market surveys eight wild edible plants were sold and can provide additional income to the local community in study districts. The wild edible plants were consumed as raw. Agricultural land expansion, fuel wood collection, cutting for construction, uncontrolled fire and overgrazing were the major threats to the wild edible plants. Hence, the finding recommend that the community that practice in on-site and off-site conservation, public awareness raising, which requires participation the government's on sustainable forest management practices approach would help to protect wild edible plant in study area.
Avian pathogenic Escherichia coli infection causes infiltration of heterophilic granulocytes of chick tracheal by the complement and coagulation cascades pathway
Authors: Li Ziqi , Qi Zhao , Wang Xiaoru , Lu Liting , Wang Haiyang , He Zhenjie , Chen Zhe , Shao Ying , Tu Jian , Song Xiangjun 
Published: July 2023

Abstract
Background
Avian pathogenic Escherichia coli (APEC) causes tracheal damage and heterophilic granulocytic infiltration and inflammation in infected chicks. In this study, we infected chick tracheal tissue with strain AE17 and produced pathological sections with proteomic sequencing. We compared the results of pathological sections from the APEC-infected group with those from the PBS control group; the pathological sections from the experimental group showed hemorrhage, fibrinization, and infiltration of heterophilic granulocytes in the tracheal tissue. To explore the effect on proteomics on inflammation and to further search for the caus.
Results
The tandem mass tag-based (TMT) sequencing analysis showed 224 upregulated and 140 downregulated proteins after infection with the AE17 strain. Based on the results of KEGG in Complement and coagulation cascades, differential protein expression in the Protein export pathway was upregulated.
Conclusions
With these results, we found that chemokines produced by the Complement and coagulation cascades pathway may cause infiltration of heterophilic granulocytes involved in inflammation, as well as antimicrobial factors produced by the complement system to fight the infection together.These results suggest that APEC causes the infiltration of heterophilic granulocytes through the involvement of the complement system with serine protease inhibitors.