bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prognostic Significance of Inflammatory Markers Level Changes in Patients with a New Coronavirus Infection
Authors: Евтеева Д.А. , Гайковая Л.Б. 
Published: June 2023

Введение. Для прогнозирования исходов новой коронавирусной инфекции важен поиск информативных воспалительных маркеров из большого числа рекомендованных. Цель. Сравнить значимость маркеров воспаления при новой коронавирусной инфекции для прогноза исхода заболевания. Материалы и методы. Сформированы две группы исследования: 1-я группа (26 человек) – с содержанием гомоцистеина (Hcy) в крови в пределах референтных значений, 2-я группа (24 человека) – с гипергомоцистеинемией (HHcy). В сыворотке крови пациентов определяли маркеры воспаления – С-реактивный белок, ферритин, гомоцистеин, интерлейкин-6, а также показатели одноуглеродного метаболизма – витамин В12, фолиевая кислота. Результаты. Для пациентов с гипергомоцистеинемией характерны более старшийвозраст, наличие хронических заболеваний ССС, почек и тромботические осложнения, а также низкая концентрация витамина В12 и высокий уровень интерлейкина-6. Сравнение воспалительных маркеров проводилось с помощью бинарной логистической регрессии, построены ROC-кривые. Заключение. Уровень гомоцистеина в крови у пациентов пожилого возраста с новой коронавирусной инфекцией является более чувствительным прогностическим маркером неблагоприятных исходов по сравнению с С-реактивным белком, ферритином и интерлейкином-6. Определение гомоцистеина в крови может быть использовано для оценки воспалительного процесса в динамике у пациентов с новой коронавирусной инфекцией.
Introduction. To predict outcomes of a new coronavirus infection is important searching of meaningful inflammatory markers among many recommended ones. Purpose. To compare the significance of inflammatory markers in a new coronavirus infection for predicting the outcome of the disease. Materials and methods. Two research groups were formed: Group 1 (26 subjects) with blood homocysteine (Hcy) within the reference values and group 2 (24 subjects) with hyperhomocysteinemia (HHcy). Inflammatory markers were determined in patients’ blood serum: C-reactive protein, ferritin, homocysteine, interleukin-6, as well as 1C metabolism laboratory indicators such as vitamin B12 and folic acid. Results. Patients with hyperhomocysteinemia were characterised by older age, chronic cardiac and renal diseases and thrombotic complications, as well as low vitamin B12 concentrations and high levels of interleukin-6. Inflammatory markers were compared using binary logistic regression, and ROC curves were constructed. Conclusion. Blood homocysteine levels in elderly patients with a new coronavirus infection are more sensitive prognostic markers of adverse outcomes compared to C-reactive protein, ferritin and interleukin-6. Blood homocysteine determination can be applied to assess the inflammatory process over time in patients with a new coronavirus infection.
Classification of restrictions on community activities level in the covid-19 pandemic using fuzzy logic
Authors: Izzah Abidatul , Widyastuti Ratna , Khalida Zulfa 
Published: June 2023

Indonesia is facing a second wave of Covid-19 cases in mid-2021. In that time, the increase reached 381 percent or almost 5 times. Therefore, the government announced the Enforcement of Restrictions on Community Activities. This is determined by the government for each city in Indonesia so it cannot be predicted by the general public. Actually, The Restrictions on Community Activities status level determines the risk of a region's economic activities. Therefore, we need a method that can help to categorize the level of PPKM in an area based on available daily data. Thus, this study aims to create a rule model based on Fuzzy Tsukamoto logic that can help determine the level of risk of an area. Based on data on Covid-19 patients in Malang District, East Java has formed 6 fuzzy variables, each of which has 4 fuzzy sets, and 15 rules that can be used as a classification model. From the results, we obtained an accuracy value of 80%. This shows that the generated rule can properly classify the daily Covid-19 data to then estimate the next restrictions level.
Group delay compensation based on negative group velocity effect of spoof surface plasmon polaritons
Authors: Ren Bocong , Li Weiwen , Zhang Lei , Zhang Baoping 
Published: June 2023

Abstract
Negative group velocity (NGV) exists only in the anomalous dispersion band with resonance absorption. In this paper, it is verified that spoof surface plasmon polaritons (SSPPs) with spiral-shaped periodic units have the NGV characteristics near cutoff frequency. The negative group delay of this NGV SSPP can be used to achieve the compression of the pulse signal, and also to compensate the positive group delay with high efficiency. Of course, this group delay compensation scheme based on NGV may introduce an absorption loss, which is the characteristic of all passive negative group delay circuits.
Efficient generation of singlet oxygen due to localized surface plasmon resonance of silver nanoparticles in rose bengal–silver nanoparticle composite films
Authors: Yonemura Hiroaki , Motomura Kento 
Published: June 2023

Abstract
The effect of silver nanoparticles (AgNP) on the generation of singlet oxygen (1O2*) using rose bengal (RB) as a photosensitizer for photodynamic therapy (PDT) was examined by measuring the phosphorescence spectra of 1O2* from RB-AgNP composite film and RB film on glass plates in CCl4. 1O2* was successfully detected by direct observation of the characteristic 1O2* phosphorescence around 1275 nm in two films. The excitation spectra of 1O2* in the two films were in agreement with the that of RB in film or in solution. The results indicate that the generation of 1O2* is ascribed to a PDT type Ⅱ reaction. The phosphorescence intensity of 1O2* in RB-AgNP composite film was larger than that in RB film. The enhancement of the phosphorescence intensity of 1O2* is most likely attributable to the strong electric fields due to the localized surface plasmon resonance of AgNP aggregates.
Pelatihan Aplikasi SLiMS pada SMA Negeri 18 Palembang
Authors: Elizabeth Triana , Tinaliah Tinaliah , Wijaya Novan 
Published: June 2023

SMA Negeri 18 Palembang adalah Sekolah Menengah Atas yang berlokasi di Kota Palembang, Provinsi Sumatera Selatan. Hingga saat ini SMA Negeri 18 Palembang terus maju dan berkembang pesat serta menghasilkan lulusan yang terbaik di bidangnya. Demi tercapainya visi, misi, tujuannya SMA Negeri 18 Palembang terus memberikan pelatihan kepada guru – guru yang ada. SMA 18 Palembang juga berkerja sama dengan berbagai organisasi baik yang bergerak di bidang pendidikan dan industri dalam memberikan pelatihan. Pada kesempatan kali ini, tim diundang untuk memberikan materi pelatihan terkait dengan Digitalisasi Perpustakaan dengan menggunakan aplikasi SLiMS (Senayan Library Management System) pada tenaga kependidikan dan pustakawan. Kegiatan ini telah terlaksana dengan baik dan bermanfaat bagi SMA Negeri 18 Palembang dalam mengimplementasikan digitalisasi perpustakaan.
PKM PENINGKATAN PROMOSI DAN PENYAJIAN PRODUK KATERING KELOMPOK PKK & UMKM DESA SUMBERADI MLATI SLEMAN YOGYAKARTA
Authors: Sujarwadi Agus , Susilo Dibyo , Darmawan Surya 
Published: June 2023

Program PKM yang dilaksanakan menyasar Kelompok PKK Desa Sumberadi yang memiliki unit usaha catering yang dikelola secara mandiri oleh beberapa anggotanya. Masalah yang dihadapi anggota Kelompok PKK Desa Sumberadi dalam usaha cateringnya adalah minimnya pendapatan dari usaha catering tersebut. Setidaknya ada 2 bidang yang menjadi permasalahan utama yaitu pada sektor produksi yang belum mampu menghasilkan produk dengan nilai jual yang kompetitif, sedangkan sektor kedua adalah pada bagian pemasaran, terutama jangkauan pasar yang terbatas, permintaan yang tidak stabil, dan program promosi yang kurang dilaksanakan.
Untuk mengatasi permasalahan diatas, tim pengabdian mengusulkan beberapa solusi yaitu: 1) meningkatkan daya saing produk; 2) meningkatkan keterampilan mitra terkait penyajian dan pengemasan produk; 3) Perluasan pasar; 4) peningkatan kualitas promosi; 5) penggunaan media sosial dalam program promosi.
Pelaksanaan program ini akan dilakukan dalam 4 tahap yaitu persiapan, pelaksanaan, evaluasi, dan pelaporan dengan masa efektif program sekitar 8 bulan. Sedangkan metode yang digunakan dalam pelaksanaan kegiatan adalah metode FGD, dan pelatihan (workshop) dengan mengundang narasumber yang ahli di bidangnya.
Implementasi Pendidikan Karakter di Sekolah SMK Negeri 1 Bungaraya Kecamatan Bungaraya Kabupaten Siak
Authors: Romyzal Romyzal 
Published: June 2023

Penelitian ini dilakukan untuk mengetahui bagaimana penerapan pendidikan karakter di SMK Negeri 1 Bungaraya, Kabupaten Siak, dan untuk mengetahui factor-faktor yang mempengaruhi Implementasi pendidikan karakter, serta sejauh mana penerapan yang telah dilakukan oleh guru dalam Implementasi pendidikan karakter siswa. Jenis penelitian ini ialah Penelitian kualitatif yang bersifat induktif yaitu suatu analisi berdasarkan data yang diperoleh, selanjutnya dikembangkan pada hubungan tertentu. Subjek penelitian ini adalah siswa SMK Negeri 1 Bungaraya dan Guru Pendidikan Agama Islam serta kepala sekolah. Adapun Objek penelitian ini adalah Implementasi Pendidikan Karakter. Adapun yang menjadi permasalahan dalam penelitian ini adalah, bagaimana Implementasi pendidikan karakter di SMK Negeri 1 Bungaraya, dan apa saja Faktor-faktor pendorong dan penghambat Implementasi Pendidikan Karakter di SMK 1 Bungaraya, Teknik pengumpulan data dalam penelitian ini ialah observasi, wawancara dan dokumentasi dan teknik analisis data yang digunakan ialah teknik analisis kualitatif milik Miles dan Huberman. Adapun hasil peilitian ini yaitu: Implementasi pendidikan karakter di SMK Negeri 1 Bungaraya. Dalam penerapannya sudah bagus, dalam sekian banyak peserta didik di SMK Negeri 1 Bungaraya, lebih banyak yang berdisiplin. Adapun beberapa pendorong dalam keberhasilan Implementasi pendidikan karakter ini adalah, Guru yang selalu memberikan pemahaman dan pengertian kepada peserta didik, guru yang selalu membiasakan pembiasaan yang baik, selalu memberi suri tauladan yang baik, dan memberikan reward kepada peserta didik yang berdisiplin. namun juga masih ada peserta didik yang masih kurang mentaati peraturan sekolah yang disebabkan oleh beberapa faktor, salah satunya, faktor teman sebaya, faktor lingkungan, faktor media social, faktor ekonomi, dan faktor pendidik.
MEDIA PEMBELAJARAN RUMAH ADAT BERBASIS AUGMENTED REALITY METODE SIMULTANEOUS LOCALIZATION AND MAPPING
Authors: Ainun najib Mukhamad , Ahkam Sani Dian , Zoqi Sarwani Moh. 
Published: June 2023

Salah satu keanekaragamaan budaya yang harus dijaga dan dirawat oleh generasi penerus bangsa terutama dikalangan pelajar adalah rumah adat. Terutama bagi siswa MTS Al-husaini, Rumah adat yang memeliki keunikan pada bentuk arsitekturnya menjadi materi pembelajaran. Namun media pembelajaran masih berupa buku sehingga kurang menarik minat siswa. Tujuan penerapan augmented reality pada media pembelajaran rumah adat adalah menyampaikan informasi dan meningkatkan minat belajar siswa. Dengan menampilkan 3d objek rumah adat menggunakan aplikasi. Metode simultaneous localization and mapping digunakan untuk mengembangkan aplikasi augmented reality yang penggunaannya tanpa marker sehingga memudahkan siswa dalam penggunaan. Aplikasi berhasil menampilkan 14 3d objek rumah adat dari 3 provinsi di pulau jawa yaitu Provinsi Jawa Timur, Jawa Barat, Jawa Tengah. Aplikasi menampilkan 4 menu yaitu Mulai, Panduan ,Tentang dan Keluar, Serta 4 fitur yaitu Suara,Rotasi,Scale, dan Movement. Penlitian ini menunjukkan bahwa metode SLAM dapat diimplementasikan dengan baik pada media pembelajaran rumah adat berbasis augmented reality. Dan mampu meningkatkan minat siswa dalam belajar tentang budaya rumah adat ditunjukkan oleh hasil kuisoner yang diberikan kepada 21 siswa MTS Al-husaini kelas 8 sebesar 78,76% yang termasuk dalam kategori setuju dan hasil uji posttest dan pretest dengan n-gain score sebesar 56,17 yang dikategorikan cukup efektif.
Perbandingan Konsumsi Buah Naga dan Sari Kacang Hijau terhadap Peningkatan Kadar Hb pada Ibu Hamil Anemia di Wilayah Puskesmas Mranggen II Kecamatan Mranggen Kabupaten Demak
Authors: Dewi Andang Prastika  , Amanda Sasha Febiani  , Budi Astyandini  
Published: June 2023

ABSTRACT
Background: Anemia is still a complex health problem in Indonesian women. The most common cause of anemia in pregnancy is lack of nutrients in the body. Pharmacological treatment has side effects faster than non-pharmacological treatment. Natural products that are traditionally used as an additional intake in the prevention of anemia, for example there are dragon fruit, green beans, and so on.
Purpose: The purpose of this study was to determine the effectiveness comparison between consumption of dragon fruit and mung bean juice on increasing Hb levels in anemia pregnant women in the Mranggen II Public Health Center, Demak Regency.
This type of research is quantitative research with a research design using Two Group Pretest Posttest Design. The population in this study were pregnant women with anemia. Sampling using the entire population of as many as 40 respondents. Giving dragon fruit in the form of pieces shows 100% of the ingredients used and green beans are made by boiling to get the juice from the green beans. The research instrument was the Easy Touch Hb test as a measuring tool for Hb levels. Data analysis used Paired T-Test / T-dependent test.
Result: The results showed that the average hemoglobin level of pregnant women with anemia in the intervention group before being given Dragon Fruit had a Mean value of 10.241 g/dl, while after the intervention the Mean value became 11.125 g/dl. The Hb level in the control group before being given Mung Bean Extract had a Mean value of 10.825 g/dl while after being given Mung Bean Extract the Mean value became 11.266 g/dl. The results of the statistical test using the Independent T-Test between the two intervention groups and the control group showed p-values 0.539 which means there is no difference in the effectiveness of giving Dragon Fruit and Green Bean Extract to increase Hb levels in pregnant women with anemia.
Keywords: Dragon fruit, Green Beans, Increased Hb levels, pregnancy
Status Pekerjaan Ibu dengan Perkembangan Balita Usia 3 Sampai 5 Tahun di Paud Permata Hati Al Mahalli
Authors: Nurul Oktavia Setia Utami  , Era Revika  , Nur’aeni Eka Sari  
Published: June 2023

ABSTRACTBackground: Children can optimally achieve 4 aspects of development (fine motor, gross motor, language, and social) if they get stimulation from an early age. Many factors affect the growth and development of children. Parents or companions can do the stimulation. Parents, especially mothers, play an essential role in the process of growth and development of children. Currently, mothers have various roles, one of which is being a working mother.Objective: This study aimed to determine the correlation between the mother's employment status and the development of toddlers aged 3 to 5 years at Permata Hati Al Mahalli
Method: This is an observational analytic study with a cross-sectional approach. This study used total sampling to get 35 respondents of mothers and toddlers. Data collection was carried out using mother respondent identity sheets and the results of the Pre-screening Developmental Questionnaire (PDQ) for assessing toddler development. Data analysis in this study was carried out using Chi-Square.Result: This study showed that there were 7 (35%) toddlers with dubious development out of 20 working mothers and 1 (6.7%) toddler with dubious development out of 15 non-working mothers. The chi-square test results showed df = 1 at a significant level of 5% with a p-value of 0.048 <0.05.Conclusion: Mother's employment status is significantly correlated with the development of toddlers aged 3 to 5 years at Permata Hati Al MahalliKeywords: Mother's employment status, toddlers’ development
DETERMINATION OF THE CHRONIC TOXICITY PARAMETERS OF THE COMPLEX REMEDY FOR THE TREATMENT OF CYSTICERCOSIS IN RABBITS
Authors: Bogach М. , Perotska L. , Bogach D. , Horobei O. 
Published: June 2023

The article presents the data of a preclinical test of a means for the treatment of cysticercosis in rabbits by intra-gastric administration to white mice. Cysticercus pisiformis is a disease caused by ingestion of eggs of Taenia pisiformis in food or water, a tapeworm that parasitizes the small intestine of dogs and other carnivores. As a result of the invasion, the body loses its ability to fully function, the resistance of the immune system to infectious diseases decreases. In order to avoid the spread of the disease, it is necessary to make a timely diagnosis. The obtained data can be used to take the necessary measures against infestations and are important to prevent the selective use of anti-parasitic agents, which can lead to anthelmintic resistance.
The purpose of the work was to determine the parameters of chronic toxicity of the developed complex anti-parasitic agent for the treatment of rabbits for cysticercosis on white mice under experimental conditions.
The animals of the experimental groups were given an aqueous mixture of 0.0002 dm3 of the drug containing the following doses of the drug daily for 12 days: 1/100 DL50 ‒ 16.80 mg/kg (I group); 1/50 DL50 ‒ 33.58 mg/kg (II group); 1/25 DL50 ‒ 67.18 mg/kg (III group). On the next day after the last administration of the drug, on mice, under the condition of light ether narcosis, blood samples were taken for morphological and biochemical studies.
The agent for the treatment of cysticercosis in rabbits, at doses of 1/50 DL50 and 1/25 DL50, resulted in a slight decrease in hemoglobin content and erythrocyte count compared to the control, but it did not suppress bone marrow erythropoiesis in laboratory animals. A decrease in the number of lymphocytes and a slight increase in the level of neutrophils were recorded, which indicates the irritating effect of increased doses of the active substance of the drug. According to the classification of chemical substances by degree of danger (DST 12.1.007–76), it belongs to the class of "moderately toxic substances".
CHARACTERIZATION OF THE MAIN ETIOLOGICAL FACTORS OF THE OCCURRENCE OF MASTITIS IN COWS IN THE CONDITIONS OF "POLTAVAZERNOPRODUKT"
Authors: Nesteruk V. S. , Nahorna L. V. 
Published: June 2023

The article presents the results on the study of the main etiological factors for the occurrence of mastitis in the conditions of farms of the agricultural enterprise "Poltavazernoprodukt". Various pathologies of the mammary gland do not lose their relevance. They are among the leading causes leading to economic losses in farms due to lack of milk, reduction of its grade and culling of cows in the first lactation, or even after the first calving. The work was carried out throughout 2021 in the conditions of farms with intensive technologies for the production of marketable milk. The frequency of occurrence of mastitis was studied in the course of the research, the main etiological factors that influenced the frequency of their occurrence were determined. As a result of a complex of studies of cows at different stages of lactation, it was found that a combination of factors influenced the manifestation of mastitis. The problems were similar and the dynamics of detection of mastitis in cows also did not differ in both farms.
The main cause that provoked the occurrence of mastitis was found to be the influence of the association of microorganisms on the mammary gland. After carrying out a complex of bacteriological studies of milk samples obtained from cows in experimental farms, we found that cultures of microorganisms were identified in milk: S. aureus, S. agalactiae, E. сoli, S. lactis, S. epidermidis. The species spectrum of microorganisms identified from milk depended on the form of mastitis. In clinical forms of mastitis, cultures of S. aureus (58.4%), S. agalactiae (28.3%) and E. сoli (13.2%) were more often identified. In subclinical forms of mastitis, the spectrum of isolated microflora was somewhat different, in particular, cultures of S. aureus were isolated in 40.2%, S. agalactiae - 24.5 %, S. lactis - 19.3 %, S. epidermidis - 10.2 %, E. сoli - 5.8%. A predisposing factor to the occurrence of mastitis in cows was the use of straw as bedding, which is a very good organic substrate for the development of microorganisms. Since we found the remains of damp bedding in the stalls on both farms, an additional factor of influence through bedding is also relevant. Factors of non-infectious origin that provoke the occurrence of mastitis, including various types of trauma, also occur, however, in the general structure of registered cases of mastitis, they did not exceed 3-5 %.
DEVELOPMENT AND VALIDATION OF HPLC-METHOD FOR SIMULTANEOUS QUANTITATIVE DETERMINATION OF IMIDACLOPRID AND IVERMECTIN IN DROPS AGAINST FLEAS AND TICKS
Authors: Ostapiv R. D. , Tkachenko V. І. , Humeniuk S. L. , Samarska L. K. 
Published: June 2023

Imidacloprid and ivermectin are selective blockers of metabotropic ion receptors of the nervous system of invertebrates, leading to paralysis and death of ecto- and endoparasites. These active substances are used in insect-acaricidal drops to kill lice, fleas and ticks in cattle, domestic animals and pets.
The aim of the work was to develop a method for the identification and simultaneous quantitative determination of imidacloprid and ivermectin in drops for external use. The method was developed and validated by selectivity, linearity and suitability parameters of the chromatographic system. Drops for external use were used as a sample-object for development. The standard sample and the test sample were dissolved in acetonitrile to a concentration of imidacloprid 100 μg/ml and ivermectin 10 µg/ml. The samples were separated on a Dionex Ultimate 3000 chromatography system equipped with a chromatographic column Acclaim C18 150×4.6, 5 μm. The mobile phase was a mixture of acetonitrile and water in a volume ratio of 90:10. Ivermectin and imidacloprid were detected at an absorption wavelength of 242 nm.
Under the above-mentioned conditions, it was possible to completely separate imidacloprid and ivermectin (retention time of chromatographic peaks – 2.0 min and 10.0 min) and other components of the studied drug. At the same time, the suitability parameters of the chromatographic system did not exceed the limits specified in the recommendations of the USA Food and Drug Association. For the peaks of imidacloprid and ivermectin, the efficiency of the chromatographic system was 8000–10000 theoretical plates. The relative standard deviation (RSD) for the peak areas of the active substances was ± 0.31%, and the peak separation ratio (RS) of imidacloprid from ivermectin and other drug components was 35.9. The symmetry coefficient of the imidacloprid peak was 1.5, and that of ivermectin was 1.1. The calibration curves were linear in the recommended DFU 2.0 range (80–120% of the nominal concentration of the corresponding active substance). The coefficient of linearity (R2) for imidacloprid was 0.9991, and for ivermectin it was 0.9993.