bluuebunny/crossref_metadata_2025_split huggingface dataset:
Artificial Intelligence–Enabled Software Prototype to Inform Opioid Pharmacovigilance From Electronic Health Records: Development and Usability Study
Authors: Sorbello Alfred , Haque Syed Arefinul , Hasan Rashedul , Jermyn Richard , Hussein Ahmad , Vega Alex , Zembrzuski Krzysztof , Ripple Anna , Ahadpour Mitra 
Published: July 2023

Background
The use of patient health and treatment information captured in structured and unstructured formats in computerized electronic health record (EHR) repositories could potentially augment the detection of safety signals for drug products regulated by the US Food and Drug Administration (FDA). Natural language processing and other artificial intelligence (AI) techniques provide novel methodologies that could be leveraged to extract clinically useful information from EHR resources.

Objective
Our aim is to develop a novel AI-enabled software prototype to identify adverse drug event (ADE) safety signals from free-text discharge summaries in EHRs to enhance opioid drug safety and research activities at the FDA.

Methods
We developed a prototype for web-based software that leverages keyword and trigger-phrase searching with rule-based algorithms and deep learning to extract candidate ADEs for specific opioid drugs from discharge summaries in the Medical Information Mart for Intensive Care III (MIMIC III) database. The prototype uses MedSpacy components to identify relevant sections of discharge summaries and a pretrained natural language processing (NLP) model, Spark NLP for Healthcare, for named entity recognition. Fifteen FDA staff members provided feedback on the prototype’s features and functionalities.

Results
Using the prototype, we were able to identify known, labeled, opioid-related adverse drug reactions from text in EHRs. The AI-enabled model achieved accuracy, recall, precision, and F1-scores of 0.66, 0.69, 0.64, and 0.67, respectively. FDA participants assessed the prototype as highly desirable in user satisfaction, visualizations, and in the potential to support drug safety signal detection for opioid drugs from EHR data while saving time and manual effort. Actionable design recommendations included (1) enlarging the tabs and visualizations; (2) enabling more flexibility and customizations to fit end users’ individual needs; (3) providing additional instructional resources; (4) adding multiple graph export functionality; and (5) adding project summaries.

Conclusions
The novel prototype uses innovative AI-based techniques to automate searching for, extracting, and analyzing clinically useful information captured in unstructured text in EHRs. It increases efficiency in harnessing real-world data for opioid drug safety and increases the usability of the data to support regulatory review while decreasing the manual research burden.
ANALISIS PENGUKURAN KINERJA KEUANGAN PADA DINAS TENAGA KERJA, KOPERASI DAN UKM PEMERINTAH KOTA JAMBI BERDASARKAN KONSEP VALUE FOR MONEY
Authors: Pratama Angga , Sam Iskandar , Erwati Misni 
Published: July 2023

Tujuan Penelitian ini adalah untuk mengetahui kinerja anggaran keuangan Dinas Tenaga Kerja Koperasi dan UKM Kota jambi ditinjau Value For Money. Dalam penelitian ini,pengukuran nilai ekonomi menggunakan perbandingan realisasi biaya dengan anggaran biaya. Nilai efisiensi menggunakan perbandingan output dan input dari data LAKIP Dinas Tenaga Kerja Koperasi dan UKM Pemerintah Kota Jambi, sedangkan nilai efektivitas dihitung berdasarkan perbandingan nilai outcome dan output. Adapun data yang dianalisis adalah anggaran program kegiatan pada Dinas Tenaga Kerja Koperasi dan UKM pemerintah Kota Jambi tahun 2017-2019. Hasil penelitian ini dapat dikatakan ekonomis jika perhitungannya menunjukan kurang dari 100%, untuk rasio efisiensi dapat dikatakan efektif jika hasil menunjukan nilai lebiih dari 100%, sedangkan efektivitas dapat dikatakan efektif jika hasil perhitungannya menunjukan nilai mendekati 100%. Adapun perhitungan rasio ekonomi pada tahun 2017 sampai dengan 2019 adalah sebesar 94,25%, 91,71%, 94,97%. Perhitungan rasio efisiensi Pada tahun 2017 sampai dengan 2019 masing-masing sebesar 100,55%, 102,07%,101,74%. Sedangkan untuk rasio efektivitas tahun angggaran 2017 sampai dengan 2019 adalah amsing-masing adalah 100%.
Implementation of 21st Century Learning through the Development of ICT-Assisted Learning Media in Elementary School
Authors: FURKAN IZZAN MUHAMMAD , Yanti Fitria 
Published: July 2023

This research is motivated by the lack of available learning media for integrated thematic learning in Theme 6: Heat and Its Transfer, based on ICT (Information and Communication Technology) in schools. One of the ICT-based media is Articulate Storyline 3, designed to be as attractive as possible by incorporating audio, images, videos, games, and quizzes, aiming to motivate and actively engage students in learning. This research is a development research (R&D) using the ADDIE model, which consists of five stages: analysis, design, development, implementation, and evaluation.
The results of this research obtained an average validation score of 94.9% with a valid category. The teacher's questionnaire response obtained a score of 93.75% with a highly practical category, while the student's questionnaire response at SDN 07 Pasar Salido obtained a score of 97.92% with a highly practical category. The student's questionnaire response on the media deployment at SDN 22 Kampung Luar Salido obtained a score of 94.79% with a highly practical category. The effectiveness of the learning media at SDN 22 Kampung Luar Salido, based on the percentage of improvement in student learning outcomes, showed an average increase. In the 4th lesson at SDN 22 Kampung Luar Salido, it was 95% with a highly effective category, while in the 5th lesson at SDN 22 Kampung Luar Salido, it was 90% with a highly effective category. Thus, it can be concluded that Articulate Storyline 3 media is deemed suitable for use in teaching and learning.
Degradation marks of phonograph cylinders from Tesař’s opera collection
Authors: Benetková Barbora Mašek , Korandová Petra , Boumová Kristýna , Sýkorová Hana , Kadavá Jana , Studničný Michal , Šefců Radka , Mejzr Martin , Šír Filip 
Published: July 2023

Abstract
Phonograph cylinders are the oldest commercially available recording media and are an valuable part of cultural institutions’ collections. Even though they are an essential part of sound history, they have long been overlooked as a relatively chemically stable media. The only degradation mentioned in the literature was a whitish cover, traditionally appointed to microbiological growth. In our study, we focused on unravelling the issue of these degradation products. A selected collection from the National Museum – Czech Museum of Music was subjected to microbiological and analytical examination via digital microscopy, FTIR spectroscopy, colourimetry and SEM-EDS analysis. From the results, some of the degradation pathways were proposed. The results also help us to focus future research and suppress the degradation so that the cylinders stay longer in conditions fit for digitisation and overall archivation.
Economic and pedagogical methods in conducting experiments in the system of cognitive sciences
Authors: Галаева А.М. 
Published: July 2023

Парадигмальный подход предлагает рассматривать науку как вид коллективной человеческой деятельности, учитывая роль всех факторов, влияющих на ее реализацию, как эпистемных, так и социокультурных. Томас Кун обосновал революционный характер исторических трансформаций в науке, отрицая тем самым кумулятивистскую модель ее развития с поступательно-эволюционной траекторией изменений. Наука, в рамках позитивизма, представала безличностным процессом получения знания с жесткой внутренней логикой развития. Соответственно, неуместным и нелегитимным было применение моральных или любых других видов оценки как самого процесса научного познания, так и к его результатам. Считалось, что плоскость логики научного прогресса непосредственно недотична к ценностносмысловой сфере, они не противоречат друг другу, но и не пересекаются. Зато парадигмальный подход открыл новые перспективы исследований в философии науки, в частности способствовал так называемым аксиологическому и антропологическом поворотам – обращению к проблеме ценностей, особенно нравственных, актуализации принципов гуманизма и гуманитаризации научного знания.
The paradigmatic approach suggests considering science as a kind of collective human activity, taking into account the role of all factors influencing its implementation, both epistemic and socio-cultural. Thomas Kuhn justified the revolutionary nature of historical transformations in science, thereby denying the cumulative model of its development with a progressive evolutionary trajectory of changes. Science, within the framework of positivism, appeared to be an impersonal process of obtaining knowledge with a rigid internal logic of development. Accordingly, it was inappropriate and illegitimate to apply moral or any other types of assessment both to the process of scientific cognition itself and to its results. It was believed that the plane of the logic of scientific progress is directly undiotic to the value-semantic sphere, they do not contradict each other, but they do not intersect. But the paradigmatic approach opened up new prospects for research in the philosophy of science, in particular, it contributed to the so–called axiological and anthropological turns - addressing the problem of values, especially moral ones, actualization of the principles of humanism and humanitarization of scientific knowledge.
Caracterización fisicoquímica y sensorial del pulque producido en la zona sur del estado de Guanajuato
Authors: Flores-Rodríguez E. , Miranda-López R. 
Published: July 2023

El pulque es una bebida alcohólica tradicional mexicana que se produce a partir de la fermentación de la savia dulce que se extrae del tallo de diversas especies del género Agave, es un líquido color blanquecino, consistencia viscosa, ligeramente ácido y con bajo contenido de alcohol. En este estudio se evaluaron las propiedades fisicoquímicas y se desarrolló un perfil sensorial a través de un análisis descriptivo cuantitativo (ADC) para aroma, sabor y resabio del pulque producido en los municipios de Comonfort (COM), Tarimoro (TAR) y Valle de Santiago (VDS), ubicados al sur del estado de Guanajuato. Los resultados mostraron diferencia significativa (p<0.05) para TAR en los parámetros de pH (3.68±0.01), SST (8.46±0.05 °Bx), alcohol (4.7%) y densidad (1 g/mL) respecto COM y VDS. El perfil sensorial identificó 19 descriptores distribuidos para aroma, sabor y resabio, predominando los aromas a manzana (5.1±0.6), nota alcohólica (4±0.6) y vinagre de manzana (3.4±1); ácido (5.4±0.5ª), dulce (4.1±1a) y ácido (3.9±0.8a) para sabor; y para resabio sidra (3.7±0.5ª) y levadura (3.1±1ª y 2.6±0.5ª). Esto sugiere que las propiedades sensoriales y fisicoquímicas podrían estar relacionadas con la región en la que se produce el pulque.
Producción de Harina de Camote y su uso en Pan de caja
Authors: Vázquez-Chávez L. , Hernández-López C. 
Published: July 2023

Se determinaron las propiedades químicas de camote fresco amarillo (Ipomoea batatas L.). Los tubérculos de camote fueron seleccionados, lavados, pelados, rebanados, blanqueados, escurridos, secados y molidos para obtener harina. La harina de camote presentó menos cantidad de proteínas, que la harina de trigo aunque es rico en contenido de fibra dietética carbohidratos y carotenos, siendo buena combinación para el pan. La harina de trigo se mezcló con harina de camote; 100:0, 90:10, 85:15, 80:20. Se hicieron evaluaciones de las diferentes mezclas de harinas trigo–camote y de los panes obtenidos con las diferentes mezclas y se realizó la evaluación sensorial. El análisis sensorial incluyo textura, color, sabor, gusto y aceptabilidad general. El tratamiento preferido por los panelistas fue el tratamiento con hasta 15% de harina de camote. Los resultados revelaron que a medida que se añadió más harina de camote a la harina de trigo, hubo cambios significativos en las propiedades funcionales.
Titanium Microtexture 101, Part II
Authors: Harr Michelle , Pilchak Adam , Semiatin Lee 
Published: July 2023

Abstract
This article, the second in a two-part series on titanium alloys, examines the effects of microtexture on deformation behavior, slip dislocations, and fatigue properties. Part I, which appeared in the April 2021 issue, described microstructural evolution processes that result in microtexture formation.
Meningkatkan Kualitas Pendidikan Melalui Pendekatan Klinis dalam Supervisi Pendidikan
Authors: Rahmadini Marlian , Jamilus Jamilus 
Published: July 2023

Pendidikan merupakan suatu kebutuhan yang sangat penting bagi setiap bangsa dan negara, karena pendidikan menyangkut masa depan seseorang, masa depan bangsa dan negara. Keberhasilan pendidikan tidak terlepas dari kualitas pendidikan yang dihasilkan. Salah satu faktor penentu kualitas pendidikan ini dapat dilihat dari kualitas kinerja guru dalam lembaga pendidikan tersebut. Kualitas kinerja guru dapat dipengaruhi oleh bagaimana seorang kepala sekolah sebagai supervisor mampu untuk meningkatkan kualitas profesionalisme kinerja guru dan kesejahteraannya. Kepala sekolah dalam pendidikan perlu mengubah pandangan yang bersifat otoriter dan pengawasan menjadi tindakan konstruktif dan kreatif serta membimbing dan mengevaluasi kinerja guru-guru dalam rangka meningkatkan kualitas pendidikan yang efektif dan efisien. Kualitas pendidikan ini dapat dilakukan melalui penerapan pendekatan klinis dalam supervisi pendidikan. Pendekatan klinis merupakan bentuk pengawasan untuk menganalisis kemampuan guru dalam pengembangan proses pembelajan dan pembinaan guru secara preventif dan kuratif. Dengan pendekatan klinis maka dapat membuat guru menyadari akan fungsinya sebagai pendidikan profesional.
Diagnóstico de estructuras basado en vibraciones a partir de una red local de acelerógrafos
Authors: Mendez Serrano Rosalin Del Carmen , Gómez Ríos Margie Elena , Ho González Carlos Agustín 
Published: July 2023

La evaluación para establecer las necesidades de una estructura es bastante compleja y más si se requiere información que no está disponible. Por consiguiente, es necesario el análisis y estrategias experimentales; ya que las guías y normativas disponibles para la evaluación de estructuras existentes están limitadas al juicio ingenieril y particularidades de cada caso, lo cual hace que estas no puedan ser fácilmente definidas o estandarizadas.
Por lo tanto, el objetivo de esta investigación se enfoca en validar la eficiencia del análisis de vibraciones, para diagnosticar problemas estructurales, comparado con metodologías tradicionales que incorporan el uso de técnicas no destructivas en una estructura operativa. Para tales efectos, se presenta el caso de estudio de una edificación residencial, donde se evaluó un sistema de paredes que han presentado de manera persistente agrietamientos; a pesar de que algunos de estos elementos fueron reemplazados completamente.
Se efectuó un monitoreo de respuestas de vibraciones y la data se utilizó para elaborar modelos matemáticos, cuyos errores de ajuste sirvieron para el diseño de indicadores de daños que en conjunto con técnicas de Machine Learning, para el reconocimiento estadístico de patrones, se pudo caracterizar dinámicamente el sistema estudiado y diagnosticar que este no presentaba un desempeño anómalo que pudiera haber influenciado el comportamiento deficiente de los sistemas de mampostería.
Non-lethal suicidal behavior in university students of Spain during COVID-19
Authors: Ramos-Martín Javier , Pérez-Berlanga José Manuel , Oliver Jesús , Moreno-Küstner Berta 
Published: July 2023

BackgroundSuicide is the fourth external cause of death in the world, in persons between the ages of l5 and 29. The objectives of this study were to measure the prevalence of suicidal behavior in university students and analyze the relationship of suicide risk with psychological distress, resilience, and family and social support.MethodsAn observational and transversal study wherein the students at the University of Malaga (Spain) completed an online questionnaire which included items from different scales, sociodemographic and academic questions, and the subjective impact of the COVID-19 pandemic. Descriptive analyses and prevalence rates of suicidal behavior were calculated, and bivariate analyses, multiple linear regression, and a mediation and moderation analyses were conducted.ResultsA total of 2,212 students completed the questionnaire. The prevalence of the last 6 months was 30.4% wishing for death, 14.7% suicidal ideation, 5% self-harm injuries, and 0.5% suicide attempts. Psychological distress, family and social support were linked to the risk of suicide. Lastly, resilience and family support measure and moderate the relation between psychological stress and suicide risk.ConclusionPsychological distress is a risk factor for suicidal behavior, while resilience and family and social support are linked to a lower risk of suicide.
HERNIA INGUINOESCROTAL GIGANTE: UN CASO INFRECUENTE
Authors: MuñozPérez David Felipe , Medina Rojas Rolando , Torres Restrepo Juan Manuel , Saavedra Henao Juan David 
Published: July 2023

Introducción. Las hernias de la pared abdominal afectan entre el 10 al 15% de la población mundial, siendo hasta el 60% de estas hernias inguinales. Las hernias inguinales gigantes son poco comunes, pero con una gran carga de enfermedad para el paciente. Caso clínico. Se presenta el caso de un paciente de 51 años, con antecedente de diabetes mellitus tipo II, proveniente de zona rural aislada, por cuatro días de evolución consistente en quemadura escrotal por metal caliente, relacionada a una hernia inguinoescrotal derecha gigante. Es llevado a intervención quirúrgica por cirugía general y urología. Por adecuada evolución clínica se da de alta al 5to día posoperatorio.Discusión. Las hernias inguinales gigantes son raras y frecuentemente se presentan en pacientes de bajo estrato socioeconómico, procedencia rural y cierto grado de negligencia. El reto del equipo quirúrgico consiste en lidiar con los posibles efectos adversos de la reducción del contenido herniario en un abdomen con diversos grados de perdida del dominio. Se puede requerir resección o debulking del contenido abdominal o la expansión de la cavidad abdominal mediante frenectomía, neumoperitoneo progresivo perioperatorio o la creación de hernias ventrales mediante maniobras avanzadas. La reparación con malla libre de tensión disminuye el riesgo de recurrencia. Conclusión: La hernia inguinal gigante es una patología rara. El cirujano general está llamado a conocer el abanico de opciones que existen en caso de enfrentarse a estos pacientes, lo cual ayuda a reducir la elevada morbimortalidad y altas tasas de recurrencia.
ADENOMA PARATIROIDEO ECTOPICO MEDIASTINICO, REPORTE DE UN CASO
Authors: Rocha Anguita Luis Fernando , Borel Baeza Claudio Andres 
Published: July 2023

Paciente que consulta en urgencia por anorexia, náuseas y compromiso del estado general. Ingresa con diagnóstico de Hipercalcemia severa e Hiperparatiroidismo primario. Estudio de imágenes revela Adenoma paratiroideo quístico con componente cervical pequeño, mayor en mediastino. Es intervenida quirúrgicamente, realizando extirpación quirúrgica del tumor, cuya biopsia fue compatible con Adenoma paratiroideo quístico. Las glándulas paratiroides ectópicas se presentan dada la migración anormal durante la embriogénesis. El Hiperparatiroidismo primario se debe en un 85% de los casos a un adenoma. Los adenomas ectópicos, se presentan entre un 15-20% de los casos. La ubicación mediastínica debe ser considerada siempre dentro del estudio.
Evaluación angiográfica de la distribución anatómica de la irrigación sanguínea del ángulo esplénico del colon en población chilena
Authors: Pruzzo Garate Matias Felipe , Acuña R. Mauricio , Lopez Nuñez Sebastian Andres , Via Dorado C. José , Salazar V. Elias , Campaña V. Gonzalo 
Published: July 2023

Objetivo: Identificar los patrones de distribución vascular del ángulo esplénico del colon (AEC) en la población chilena para su comparación con la literatura oriental (Fukuoka).Materiales y métodos: Estudio descriptivo, transversal. Se caracterizó la irrigación del AEC de imágenes con protocolo Urotac realizadas en Clínica INDISA entre el año 2020 y 2021 (n=127), clasificándolas dentro de 6 tipos descritos por Fukuoka. Se evaluaron características demográficas y comorbilidades. Las variables fueron analizadas utilizando estadística descriptiva y la significancia mediante la prueba Chi2.Resultados: Existen diferencias en los tipos irrigación del AEC entre la serie local y Fukuoka, la irrigación tipo 3 fue la que presentó mayor variación (p<0,05). El tipo 1 es la más frecuente (34,7%), sin casos del Tipo 4. No se identificó diferencia entre los distintos tipos de irrigación con relación a las variables demográficas y comorbilidades.Discusión: Al comparar nuestra serie con la oriental se evidenció similar frecuencia en tipos 1 y 6, mayor en tipos 3 y 5, y tipos 2 y 4 con menor representación. Se identificó un mayor aporte en la irrigación del AEC por la arteria cólica izquierda (ACI) en la población estudiada (64,6%). Conclusión: Nuestra población tiene mayor participación de ACI en irrigación del AEC que orientales (64,6% vs 49,6%), los tipos más frecuentes son 1, 3 y 6, el Tipo 1 es la forma más frecuente de irrigación, similar a Fukuoka (34,7% vs 39,7%), Tipo 3 tiene mayor representación en nuestra población que en la oriental (29,9% vs 9,9%).
ĐÁNH GIÁ KẾT QUẢ PHỤC HỒI CHỨC NĂNG KHỚP VAI SAU PHẪU THUẬT NỘI SOI TỔN THƯƠNG CHÓP XOAY
Authors: Nguyễn Văn Vĩ , Trần Trung Dũng , Phạm Văn Minh 
Published: July 2023

Mục tiêu: Đánh giá kết quả phục hồi chức năng khớp vai sau phẫu thuật nội soi tổn thương chóp xoay. Đối tượng và phương pháp: 30 bệnh nhân đã được phẫu thuật nội soi điều trị tổn thương chóp xoay khớp vai theo kỹ thuật Mason-Allen cải tiến tại khoa Chấn thương chỉnh hình và được phục hồi chức năng tích cực ngay ngày đầu sau phẫu thuật. Theo dõi và đánh giá sau 1 tháng, 3 tháng và 6 tháng qua thang đánh giá khớp vai của Đại học California Los Angeles (the University of California - Los Angeles Shoulder Score). Các tiêu chí đánh giá vừa có yếu tố chủ quan vừa khách quan, dễ đánh giá, trong đó có tiêu chí sự hài lòng của bệnh nhân được khảo sát mang ý nghĩa thiết thực trong cuộc sống. Kết quả: Mức độ phục hồi cải thiện rõ rệt với sự khác biệt có ý nghĩa thống kê giữa các thời điểm đánh giá. Kết quả cuối cùng sau 6 tháng: theo UCLA số bệnh nhân đạt kết quả tốt và rất tốt đạt 86,6% (26 BN), bệnh nhân cảm thấy khớp vai hoạt động bình thường và gần như bình thường. Có 4 bênh nhân (13,3%) đạt kết quả trung bình có đạt tầm vận động khớp vai bình thường và không có triệu chứng sưng hay tràn dịch khớp khi hoạt động, chỉ đau nhẹ khi làm một số hoạt động mạnh; không có bệnh nhân đạt kết quả kém; 100% bệnh nhân hài lòng về kết quả điều trị. Kết luận: Phương pháp PHCN của nhóm nghiên cứu đưa ra và áp dụng đã mang lại kết quả tốt cho người bệnh.
EXPERIMENTAL STUDY OF RADIATION HEAT TRANSFER OVER VERTICALLY PLACED CIRCULAR DISKS
Authors: Rabby Md Insiat Islam , Das Sudipto Tushar , Sheikh Morsalin , Iman Safwan-Ul 
Published: July 2023

The radiation heat transfer over vertically placed circular disks under vacuum and air medium were experimentally investigated. Two type’s disks black and grey were considered for the study, which were placed vertically inside a heated chamber called an oven. A constant temperature was imposed inside the chamber. The chamber was partially vacuumed to prepare vacuum medium by controlling the air pressure with -0.8 to 0.6 bar. To understand the heat transfer, time requirement to obtain certain temperatures and heat transfer coefficient were calculated. Correlation between temperature and heat transfer coefficient were also analyzed. The findings highlighted that black disk provided the highest heat transfer coefficient and the lowest time requirement to achieve a certain temperature. Polynomial relationships between temperature and heat transfer coefficient for black and grey disks with R2 less than 1 were obtained through the trendlines.