bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perceptions of Illicit Tobacco Sources Following a Proposed Reduction in Tobacco Availability: A Qualitative Analysis of New Zealanders Who Smoke
Authors: Hoek Janet , Graham-DeMello Anna , Wilson Nick 
Published: March 2023

Abstract

Introduction
Tobacco companies claim that substantially reducing tobacco retail outlets in Aotearoa New Zealand will increase illicit tobacco trade and crime. However, we know little about whether people who smoke anticipate using illicit tobacco once this measure is implemented. Exploring current illicit tobacco use and expected market development would clarify the likely scale of this potential problem.

Aims and Methods
We undertook online in-depth interviews with 24 adults who smoke and explored their experiences of illicit tobacco, perceptions of illicit market growth once legal tobacco became less available, intentions to engage in this market, and potential measures that could curb illicit market development. We interpreted the data using a qualitative descriptive approach.

Results
Few participants had purchased illegally imported or stolen tobacco. While most did not know how to access illicit tobacco products, many expected illicit trade and crime would increase, if legal tobacco became difficult to access. While cheaper tobacco appealed to many, most perceived illicit supply routes as unsafe and saw products obtained via these sources as likely to be of poor quality. Few suggested measures to control illicit markets, though a minority called for social reforms to reduce poverty, which they thought fueled illegal practices.

Conclusions
Although illicit trade may appear to threaten new policy initiatives, participants’ limited knowledge of these markets and concerns regarding product safety suggest illegal tobacco may pose less of a threat than tobacco companies have claimed. Policy makers should not be deterred from reducing tobacco availability by industry arguments.

Implications
Although participants believed illicit trade would increase if the number of tobacco retailers was substantially reduced, few anticipated purchasing illegal tobacco. They viewed supply routes as unsafe and product quality as likely to be low. Industry predictions that illicit tobacco trade will grow if tobacco becomes less available do not reflect how people who smoke expect to engage with these markets and should not deter the introduction of retail reduction measures.
Risk of Coronavirus Disease 2019–Associated Pulmonary Aspergillosis Based on Corticosteroid Duration in Intensive Care Patients
Authors: Shah Meera , Reveles Kelly , Moote Rebecca , Hand Elizabeth , Kellogg III Dean , Attridge Rebecca L , Maselli Diego J , Gutierrez G Christina 
Published: March 2023

AbstractBackgroundCoronavirus disease 2019 (COVID-19)–associated pulmonary aspergillosis (CAPA) is a potential complication in critically ill COVID-19 patients. Corticosteroids are standard of care for hospitalized COVID-19 patients but carry an increased risk of secondary infections including CAPA. The objective of this study was to evaluate if duration of corticosteroid therapy ≤10 days versus &gt;10 days affects the risk of developing CAPA.MethodsThis was a retrospective cohort study of adult patients with severe COVID-19 pneumonia requiring mechanical ventilation who received at least 3 days of corticosteroid treatment. Incidence of CAPA and secondary outcomes were compared using appropriate bivariable analyses. Steroid duration was evaluated as an independent predictor in a logistic regression model.ResultsA total of 278 patients were included (n = 169 for ≤10 days’ steroid duration; n = 109 for &gt;10 days). CAPA developed in 20 of 278 (7.2%) patients. Patients treated with &gt;10 days of corticosteroid therapy had significantly higher incidence of CAPA (11.9% vs 4.1%; P = .0156), and steroid duration &gt;10 days was independently associated with CAPA (odds ratio, 3.17 [95% confidence interval, 1.02–9.83]). Secondary outcomes including inpatient mortality (77.1% vs 43.2%; P &lt; .0001), mechanical ventilation–free days at 28 days (0 vs 1.5; P &lt; .0001), and secondary infections (44.9% vs 28.4% P = .0220) were worse in the &gt;10 days cohort.ConclusionsCorticosteroid treatment &gt;10 days in critically ill COVID-19 patients is associated with an increased risk of CAPA. Patients may require corticosteroids for reasons beyond COVID-19 and clinicians should be cognizant of risk of CAPA with prolonged courses.
Geospatial Analysis of Time to Human Immunodeficiency Virus (HIV) Diagnosis and Adult HIV Testing Coverage Highlights Areas for Intervention in the US Southeast
Authors: Matthews Lynn T , Long Dustin M , Bassler John , Nassel Ariann , Levitan Emily B , Heath Sonya L , Rastegar Jeremiah , Pratt Madeline C , Kempf Mirjam-Collette 
Published: March 2023

AbstractBackgroundIn the United States (US), 44% of people with human immunodeficiency virus (PWH) live in the Southeastern census region; many PWH remain undiagnosed. Novel strategies to inform testing outreach in rural states with dispersed HIV epidemics are needed.MethodsAlabama state public health HIV testing surveillance data from 2013 to 2017 were used to estimate time from infection to HIV diagnosis using CD4 T-cell depletion modeling, mapped to county. Diagnostic HIV tests performed during 2013–2021 by commercial testing entities were used to estimate HIV tests per 100 000 adults (aged 15–65 years), mapped to client ZIP Code Tabulation Area (ZCTA). We then defined testing “cold spots”: those with &lt;10% adults tested plus either (1) within or bordering 1 of the 13 counties with HIV prevalence &gt;400 cases per 100 000 population or (2) within a county with average time to diagnosis greater than the state average to inform testing outreach.ResultsTime to HIV diagnosis was a median of 3.7 (interquartile range [IQR], 0–9.2) years across Alabama, with a range of 0.06–12.25 years. Approximately 63% of counties (n = 42) had a longer time to diagnosis compared to national US estimates. Six hundred forty-three ZCTAs tested 17.3% (IQR, 10.3%–25.0%) of the adult population from 2013 to 2017. To prioritize areas for testing outreach, we generated maps to describe 47 areas of HIV-testing cold spots at the ZCTA level.ConclusionsCombining public health surveillance with commercial testing data provides a more nuanced understanding of HIV testing gaps in a state with a rural HIV epidemic and identifies areas to prioritize for testing outreach.
When Should Healthcare Workers With Coronavirus Disease 2019 (COVID-19) Return to Work? An Analysis of Follow-up Antigen Test Results After a Positive COVID Test
Authors: Baffoe-Bonnie Anthony , Swann Mandy C , Kim Hyun Sue 
Published: March 2023

AbstractA high percentage of healthcare workers (HCWs) who had met the Centers for Disease Control and Prevention criteria for returning to work 5 days after symptom onset remained positive for their return-to-work COVID-19 antigen test, suggesting continued infectiousness. Boosted HCWs were more likely to be antigen positive on their return-to-work test compared to unvaccinated HCWs, which merits further research.
Necrotizing Soft Tissue Infections in South Australia: A 15-Year Review
Authors: Tam Patrick Chung Kay , Kennedy Brendan , Ashokan Anushia 
Published: March 2023

AbstractNecrotizing soft tissue infections (NSTIs) are associated with high morbidity and mortality. We retrospectively examined the impact of empiric antimicrobials coupled with early surgery on mortality in NSTI. Early surgery independently reduced 30-day mortality (odds ratio, .16; 95% confidence interval, .05–.51; P &lt; .001) that was not further augmented by empiric antimicrobial choice.
Multiwavelength studies of G298.6−0.0: An old GeV supernova remnant interacting with molecular clouds
Authors: Yeung Paul K H , Bamba Aya , Sano Hidetoshi 
Published: March 2023

Abstract
Hadronic γ-ray sources associated with supernova remnants (SNRs) can serve as stopwatches for the escape of cosmic rays from SNRs, which gradually develops from highest-energy particles to lowest-energy particles with time. In this work, we analyze the 13.7 yr Fermi-LAT data to investigate the γ-ray feature in/around the SNR G298.6−0.0 region. With γ-ray spatial analyses, we detect three point-like components. Among them, Src-NE is at the eastern SNR shell, and Src-NW is adjacent to the western edge of this SNR. Src-NE and Src-NW demonstrate spectral breaks at energies around/below 1.8 GeV, suggesting an old SNR age of &gt;10 kyr. We also look into the X-ray emission from the G298.6−0.0 region, with the Chandra-ACIS data. We detected an extended keV source having a centrally filled structure inside the radio shell. The X-ray spectra are well fitted by a model which assumes a collisional ionization equilibrium of the thermal plasma, further supporting an old SNR age. Based on our analyses of the NANTEN CO- and ATCA-Parkes H i-line data, we determined a kinematic distance of ∼10.1 kpc from us to G298.6−0.0. This distance entails a large physical radius of the SNR of ∼15.5 pc, which is additional evidence for an old age of &gt;10 kyr. Besides this, the CO data cube enables us to three-dimensionally locate the molecular clouds (MCs) which are potentially interacting with SNR G298.6−0.0 and could account for the hadronic γ-rays detected at Src-NE or Src-NW. Furthermore, the multiwavelength observational properties unanimously imply that the SNR–MC interaction occurs mainly in the north-eastern direction.
FAR-RED INSENSITIVE 219 and phytochrome B corepress shade avoidance via modulating nuclear speckle formation
Authors: Peng Kai-Chun , Siao Wei , Hsieh Hsu-Liang 
Published: March 2023

Abstract
Plants can sense the shade from neighboring plants by detecting a reduction of the red:far-red light (R:FR) ratio. Phytochrome B (phyB) is the primary photoreceptor that perceives shade light and regulates jasmonic acid (JA) signaling. However, the molecular mechanisms underlying phyB and JA signaling integration in shade responses remain largely unknown. Here, we show the interaction of phyB and FAR-RED INSENSITIVE 219 (FIN219)/JASMONATE RESISTANT1 (JAR1) in a functional demand manner in Arabidopsis (Arabidopsis thaliana) seedling development. Genetic evidence and interaction studies indicated that phyB and FIN219 synergistically and negatively regulate shade-induced hypocotyl elongation. Moreover, phyB interacted with various isoforms of FIN219 under high and low R:FR light. Methyl jasmonate (MeJA) treatment, FIN219 mutation, and PHYBOE digalactosyldiacylglycerol synthase1-1 (dgd1-1) plants, which show increased levels of JA, altered the patterns of phyB-associated nuclear speckles under the same conditions. Surprisingly, PHYBOE dgd1-1 showed a shorter hypocotyl phenotype than its parental mutants under shade conditions. Microarray assays using PHYBOE and PHYBOE fin219-2 indicated that PHYB overexpression substantially affects defense response-related genes under shade light and coregulates expression of auxin-responsive genes with FIN219. Thus, our findings reveal that phyB substantially crosstalks with JA signaling through FIN219 to modulate seedling development under shade light.
Phylogenetic analyses of seven protein families refine the evolution of small RNA pathways in green plants
Authors: Bélanger Sébastien , Zhan Junpeng , Meyers Blake C 
Published: March 2023

Abstract
Several protein families participate in the biogenesis and function of small RNAs (sRNAs) in plants. Those with primary roles include Dicer-like (DCL), RNA-dependent RNA polymerase (RDR), and Argonaute (AGO) proteins. Protein families such as double-stranded RNA-binding (DRB), SERRATE (SE), and SUPPRESSION OF SILENCING 3 (SGS3) act as partners of DCL or RDR proteins. Here, we present curated annotations and phylogenetic analyses of seven sRNA pathway protein families performed on 196 species in the Viridiplantae (aka green plants) lineage. Our results suggest that the RDR3 proteins emerged earlier than RDR1/2/6. RDR6 is found in filamentous green algae and all land plants, suggesting that the evolution of RDR6 proteins coincides with the evolution of phased small interfering RNAs (siRNAs). We traced the origin of the 24-nt reproductive phased siRNA-associated DCL5 protein back to the American sweet flag (Acorus americanus), the earliest diverged, extant monocot species. Our analyses of AGOs identified multiple duplication events of AGO genes that were lost, retained, or further duplicated in subgroups, indicating that the evolution of AGOs is complex in monocots. The results also refine the evolution of several clades of AGO proteins, such as AGO4, AGO6, AGO17, and AGO18. Analyses of nuclear localization signal sequences and catalytic triads of AGO proteins shed light on the regulatory roles of diverse AGOs. Collectively, this work generates a curated and evolutionarily coherent annotation for gene families involved in plant sRNA biogenesis/function and provides insights into the evolution of major sRNA pathways.
Enumerating contributions of fentanyls and other factors to the unprecedented 2020 rise in opioid overdose deaths: model-based analysis
Authors: Stringfellow Erin J , Lim Tse Yang , DiGennaro Catherine , Hasgul Zeynep , Jalali Mohammad S 
Published: March 2023

Abstract
In 2020, the ongoing US opioid overdose crisis collided with the emerging COVID-19 pandemic. Opioid overdose deaths (OODs) rose an unprecedented 38%, due to a combination of COVID-19 disrupting services essential to people who use drugs, continued increases in fentanyls in the illicit drug supply, and other factors. How much did these factors contribute to increased OODs? We used a validated simulation model of the opioid overdose crisis, SOURCE, to estimate excess OODs in 2020 and the distribution of that excess attributable to various factors. Factors affecting OODs that could have been disrupted by COVID-19, and for which data were available, included opioid prescribing, naloxone distribution, and receipt of medications for opioid use disorder. We also accounted for fentanyls’ presence in the heroin supply. We estimated a total of 18,276 potential excess OODs, including 1,792 lives saved due to increases in buprenorphine receipt and naloxone distribution and decreases in opioid prescribing. Critically, growth in fentanyls drove 43% (7,879) of the excess OODs. A further 8% is attributable to first-ever declines in methadone maintenance treatment and extended-released injectable naltrexone treatment, most likely due to COVID-19-related disruptions. In all, 49% of potential excess OODs remain unexplained, at least some of which are likely due to additional COVID-19-related disruptions. While the confluence of various COVID-19-related factors could have been responsible for more than half of excess OODs, fentanyls continued to play a singular role in excess OODs, highlighting the urgency of mitigating their effects on overdoses.
Topological modularity of supermoonshine
Authors: Albert Jan , Kaidi Justin , Lin Ying-Hsuan 
Published: March 2023

AbstractThe theory of topological modular forms (TMF) predicts that elliptic genera of physical theories satisfy a certain divisibility property, determined by the theory’s gravitational anomaly. In this note we verify this prediction in Duncan’s supermoonshine module, as well as in tensor products and orbifolds thereof. Along the way we develop machinery for computing the elliptic genera of general alternating orbifolds and discuss the relation of this construction to the elusive “periodicity class” of TMF.
Referral Decision-Making and Care Continuity in Physical Therapist Practice
Authors: Peterson Seth , Heick John 
Published: March 2023

Abstract
Efficient referral pathways have held promise in improving clinical outcomes, raising patient satisfaction, and reducing costs. Referral decision-making presents a distinct challenge because it requires the consideration of such variables as technology, health-care systems, and local resources. However, best practices for generating a high-value referral and improving care continuity are rarely discussed in the context of physical therapist practice. With physical therapists in some states obtaining explicit imaging privileges and a renewed focus on the physical therapist’s role in primary care and patient management over the lifespan, it is time to focus on this underappreciated area of practice. This perspective discusses referral decision-making and provides recommendations for making a high-value referral and improving care continuity. Improving referral and care continuity has potential to enhance clinical outcomes and patient satisfaction and to reduce costs. This perspective explicitly defines and describes strategies to improve physical therapist decision-making about referral and care continuity to improve overall patient management.
Cognitive Remediation Works But How Should We Provide It? An Adaptive Randomized Controlled Trial of Delivery Methods Using a Patient Nominated Recovery Outcome in First-Episode Participants
Authors: Wykes Til , Stringer Dominic , Boadu Janette , Tinch-Taylor Rose , Csipke Emese , Cella Matteo , Pickles Andrew , McCrone Paul , Reeder Clare , Birchwood Max , Fowler David , Greenwood Kathryn , Johnson Sonia , Perez Jesus , Ritunnano Rosa , Thompson Andrew , Upthegrove Rachel , Wilson Jon , Kenny Alex , Isok Iris , Joyce Eileen M 
Published: March 2023

Abstract

Background and Hypothesis
Cognitive remediation (CR) benefits cognition and functioning in psychosis but we do not know the optimal level of therapist contact, so we evaluated the potential benefits of different CR modes.

Study Design
A multi-arm, multi-center, single-blinded, adaptive trial of therapist-supported CR. Participants from 11 NHS early intervention psychosis services were independently randomized to Independent, Group, One-to-One, or Treatment-as-usual (TAU). The primary outcome was functional recovery (Goal Attainment Scale [GAS]) at 15-weeks post randomization. Independent and TAU arms were closed after an interim analysis, and three informative contrasts tested (Group vs One-to-One, Independent vs TAU, Group + One-to-One vs TAU). Health economic analyses considered the cost per Quality Adjusted Life Year (QALY). All analyses used intention-to-treat principles.

Study Results
We analyzed 377 participants (65 Independent, 134 Group, 112 One-to-One, 66 TAU). GAS did not differ for Group vs One-to-One: Cohen’s d: 0.07, −0.25 to 0.40 95% CI, P = .655; Independent vs TAU: Cohen’s d: 0.07, −0.41 to 0.55 95% CI, P = .777. GAS and the cognitive score improved for Group + One-to-One vs TAU favoring CR (GAS: Cohen’s d: 0.57, 0.19–0.96 95% CI, P = .003; Cognitive score: Cohens d: 0.28, 0.07–0.48 95% CI, P = .008). The QALY costs were £4306 for Group vs TAU and £3170 for One-to-One vs TAU. Adverse events did not differ between treatment methods and no serious adverse events were related to treatment.

Conclusions
Both active therapist methods provided cost-effective treatment benefiting functional recovery in early psychosis and should be adopted within services. Some individuals benefited more than others so needs further investigation.

Trial registration
ISRCTN14678860 https://doi.org/10.1186/ISRCTN14678860Now closed.
Multivariate Associations Among White Matter, Neurocognition, and Social Cognition Across Individuals With Schizophrenia Spectrum Disorders and Healthy Controls
Authors: Calarco Navona , Oliver Lindsay D , Joseph Michael , Hawco Colin , Dickie Erin W , DeRosse Pamela , Gold James M , Foussias George , Argyelan Miklos , Malhotra Anil K , Buchanan Robert W , Voineskos Aristotle N 
Published: March 2023

Abstract

Background and Hypothesis
Neurocognitive and social cognitive abilities are important contributors to functional outcomes in schizophrenia spectrum disorders (SSDs). An unanswered question of considerable interest is whether neurocognitive and social cognitive deficits arise from overlapping or distinct white matter impairment(s).

Study Design
We sought to fill this gap, by harnessing a large sample of individuals from the multi-center Social Processes Initiative in the Neurobiology of the Schizophrenia(s) (SPINS) dataset, unique in its collection of advanced diffusion imaging and an extensive battery of cognitive assessments. We applied canonical correlation analysis to estimates of white matter microstructure, and cognitive performance, across people with and without an SSD.

Study Results
Our results established that white matter circuitry is dimensionally and strongly related to both neurocognition and social cognition, and that microstructure of the uncinate fasciculus and the rostral body of the corpus callosum may assume a “privileged role” subserving both. Further, we found that participant-wise estimates of white matter microstructure, weighted by cognitive performance, were largely consistent with participants’ categorical diagnosis, and predictive of (cross-sectional) functional outcomes.

Conclusions
The demonstrated strength of the relationship between white matter circuitry and neurocognition and social cognition underscores the potential for using relationships among these variables to identify biomarkers of functioning, with potential prognostic and therapeutic implications.
Open science–related policies in Europe
Authors: Moradi Sh , Abdi S 
Published: March 2023

Abstract
This study aims to review the open science (OS) policy documents, identify their subject areas, and distinguish the topics of OS support policies in seven European countries, providing a platform for practical cooperation between countries in science popularization. With a qualitative–inductive approach, all pertinent policy documents in OS were collected through documentary study, and thematic analysis was conducted to identify OS policies for each country. Finally, forty-six policy documents extracted up to December 2020 were thematically analyzed through a qualitative–inductive case study. All selected countries had developed OS policies, and these supportive policies were generally related to the three dimensions of ‘open input, open process, and open output’. In ‘open input’, recommendations for the performance of research data repositories, as well as management criteria, are considered. Most countries adopted ‘open output’ protectionist policies. Multiple policies in the ‘open process’ indicate the need for an appropriate OS platform.