bluuebunny/crossref_metadata_2025_split huggingface dataset:
Petrology and geochemistry of Li-bearing pegmatites and related granitic rocks in southern Thailand: implications for petrogenesis and lithium potential in Thailand
Authors: Fanka Alongkot , Tadthai Jaruphichaya 
Published: June 2023

Lithium (Li) can be found in many minerals, including lepidolite. Lepidolite is found in pegmatite-related tin deposits in the Phang Nga area in southern Thailand. According to their field occurrence, petrography, mineral chemistry, and whole-rock geochemistry, the Li-bearing pegmatites and the granitic rocks in the study area can be linked to tin deposits in southern Thailand as part of the SE Asian tin belt. The Li-bearing pegmatites are characterized by an abundance of lepidolite, K-feldspar, plagioclase, and quartz with some accessory minerals of fluorite, cassiterite, apatite, monazite, and beryl. The granitic rocks show various compositions, including porphyritic biotite–muscovite granite, biotite granite, and muscovite—tourmaline granite with different proportions of K-feldspar, plagioclase, quartz, biotite, muscovite, and tourmaline. Whole-rock geochemistry indicates that both the Li-bearing pegmatites and granitic rocks have a close relationship rooted in their peraluminous S-type granite affinity. The Li-bearing pegmatites evolved from highly fractionated S-type granitic rocks comparable with the Western Belt Granite of Thailand. The enrichment of large-ion lithophile elements (e.g., Rb and K) and the depletion of Ba, Nb, and Ti together with similar rare Earth element patterns reflect the collisional setting indicating the Sibumasu–West Burma and West Burma—Indo-Burma collisions during the Cretaceous to the Eocene. The crystallization pressure—temperature conditions of these rocks were 3.49–4.25 kbar and 622°C–675°C, respectively, with an emplacement depth of 13–15 km. The Li-bearing pegmatites had a relatively high average Li grade compared with those of other Li-bearing pegmatites in the world.
MBOAT7 rs641738 (C>T) is associated with NAFLD progression in men and decreased ASCVD risk in elder Chinese population
Authors: Xu Xiaoyi , Xu Hangfei , Liu Xiaohui , Zhang Shuang , Cao Zhenhuan , Qiu Lixia , Du Xiaofei , Liu Yali , Wang Gang , Zhang Li , Zhang Yang , Zhang Jing 
Published: June 2023

Background and aimThe MBOAT7 rs641738 (C&gt;T) variant has demonstrated an association with non-alcoholic fatty liver disease (NAFLD) in both adult and pediatric patients, while few studies have been conducted in elderly populations. Hence, a case–control study was undertaken to assess their correlation in elderly residents in a Beijing community.Materials and methodsA total of 1,287 participants were included. Medical history, abdominal ultrasound, and laboratory tests were recorded. Liver fat content and fibrosis stage were detected by Fibroscan. Genotyping of genomic DNA was performed using the 96.96 genotyping integrated fluidics circuit.ResultsOf the recruited subjects, 638 subjects (56.60%) had NAFLD, and 398 subjects (35.28%) had atherosclerotic cardiovascular disease (ASCVD). T allele carriage was associated with higher ALT (p=0.005) and significant fibrosis in male NAFLD patients (p=0.005) compared to CC genotype. TT genotype was associated with reduced risk of metabolic syndrome (OR=0.589, 95%CI: 0.114–0.683, p=0.005) and type 2 diabetes (OR=0.804, 95%CI: 0.277–0.296, p=0.048) in NAFLD population when compared to the CC genotype. In addition, TT genotype was also associated with reduced risk of ASCVD (OR=0.570, 95%CI:0.340–0.953, p=0.032) and less obesity (OR=0.545, 95%CI: 0.346–0.856, p=0.008) in the whole population.ConclusionMBOAT7 rs641738 (C&gt;T) variant was associated with fibrosis in male NAFLD patients. The variant also reduced risk of metabolic traits and type 2 diabetes in NAFLD and ASCVD risk in Chinese elders.
Abnormal high tides and flooding induced by the internal surge in Hiroshima Bay due to a remote typhoon
Authors: Jeong Jae-Soon , Lee Han Soo , Mori Nobuhito 
Published: June 2023

The Itsukushima Shrine is located in northern Hiroshima Bay in the Seto Inland Sea (SIS). This structure of great cultural value is preserved as one of the World Heritage Sites in Japan. The shrine was built seaside, 30 cm above the highest tide, to prevent it from submerging. However, from 2011 to 2019, the shrine was submerged four times during September due to internal surges. To study the abnormal tide event on 29 September 2011, a high-resolution numerical ocean circulation model was established using Semi-implicit Cross-scale Hydroscience Integrated System Model (SCHISM). Observed subtidal components of surface elevation in the northern part of the bay decreased due to northerly winds when the typhoon passed east off the bay. After 7–8 days of typhoon passage, the component increased abnormally in the northern part of the bay. Simulation results revealed that a destabilized density stratification by the typhoon winds most likely caused bay-scale internal waves. The internal wave developed after the typhoon passed and was caught from the kinetic energy filtered in the possible internal wave periods. The internal wave propagated southward after the typhoon passage and returned to the northern bay, causing the subtidal component to increase after 7–8 days. Sensitivity tests with various scales of the typhoon were performed, and the test results exhibited a positive relationship between the abnormal tide level and typhoon intensity to some extent. The results can be generally applied to a semi-closed bay or closed water body for internal wave generation and propagation under specific meteorological conditions for coastal protection and disaster prevention.
Gut microbiota and atopic dermatitis: a two-sample Mendelian randomization study
Authors: Xue Yan , Zhang Linzhu , Chen Yajun , Wang Han , Xie Jiang 
Published: June 2023

BackgroundAccumulating evidence suggests that alterations in gut microbiota composition and diversity are associated with Atopic dermatitis (AD). But until now, the causal association between them has been unclear.MethodsWe employed a two-sample Mendelian Randomization (MR) study to estimate the potential causality of gut microbiota on AD risk. The summary statistics related to the gut microbiota were obtained from a large-scale genome-wide genotype and 16S fecal microbiome dataset from 18,340 individuals (24 cohorts) analyzed by the MiBioGen Consortium, comprising 211 gut microbiota. AD data were also derived from strictly defined AD data collected by FinnGen biobank analysis, which included 218,467 European ancestors (5,321 AD patients and 213,146 controls). The inverse variance weighted method (IVW), weighted median (WME), and MR-Egger were used to determine the changes of AD pathogenic bacterial taxa, followed by sensitivity analysis including horizontal pleiotropy analysis, Cochran’s Q test, and the leave-one-out method to assess the reliability of the results. In addition, MR Steiger’s test was used to test the suppositional relationship between exposure and outcome.ResultsA total of 2,289 SNPs (p &lt; 1 × 10−5) were included, including 5 taxa and 17 bacterial characteristics (1 phylum, 3 classes, 1 order, 4 families, and 8 genera), after excluding the IVs with linkage disequilibrium (LD). Combining the analysis of the results of the IVW models, there were 6 biological taxa (2 families, and 4 genera) of the intestinal flora positively associated with the risk of AD and 7 biological taxa (1 phylum, 2 classes, 1 order, 1 family, and 2 genera) of the intestinal flora negatively associated. The IVW analysis results showed that Tenericutes, Mollicutes, Clostridia, Bifidobacteriaceae, Bifidobacteriales, Bifidobacterium, and Christensenellaceae R 7 group were negatively correlated with the risk of AD, while Clostridiaceae 1, Bacteroidaceae, Bacteroides, Anaerotruncus, the unknown genus, and Lachnospiraceae UCG001 showed the opposite trend. And the results of the sensitivity analysis were robust. MR Steiger’s test showed a potential causal relationship between the above intestinal flora and AD, but not vice versa.ConclusionThe present MR analysis genetically suggests a causal relationship between changes in the abundance of the gut microbiota and AD risk, thus not only providing support for gut microecological therapy of AD but also laying the groundwork for further exploration of the mechanisms by which the gut microbiota contributes to the pathogenesis of AD.
A clinical study to evaluate the safe and effective use of a new, single use stethoscope cover to enable reduction in pathogen transmission during auscultation
Authors: Nazari-Shafti Timo Z. , Meyborg Heike , Iske Jasper , Schloss Maximilian , Seeber Fabian , Friedrich Aljona , Exarchos Vasileios , Richter Anja , Falk Volkmar , Emmert Maximilian Y. 
Published: June 2023

ObjectivesStethoscopes carry a significant risk for pathogen transmission. Here, the safe use and performance of a new, non-sterile, single-use stethoscope cover (SC), that is impermeable for pathogens, was investigated by different healthcare professionals (HCPs) in the postoperative care setting of an intensive care unit (ICU).MethodsFifty-four patients underwent routine auscultations with the use of the SC (Stethoglove®, Stethoglove GmbH, Hamburg, Germany). The participating HCPs (n = 34) rated each auscultation with the SC on a 5-point Likert scale. The mean ratings of acoustic quality and the SC handling were defined as primary and secondary performance endpoint.Results534 auscultations with the SC were performed (average 15.7/user) on the lungs (36.1%), the abdomen (33.2%), the heart (28.8%), or other body-sites (1.9%). No adverse device-effects occurred. The acoustic quality was rated at 4.2 ± 0.7 (mean) with a total of 86.1% of all auscultations being rated at least as 4/5, and with no rating as below 2. The SC handling was rated at 3.7 ± 0.8 (mean) with a total of 96.4% of all auscultations being rated at least 3/5.ConclusionUsing a real-world setting, this study demonstrates that the SC can be safely and effectively used as cover for stethoscopes during auscultation. The SC may therefore represent a useful and easy-to-implement tool for preventing stethoscope-mediated infections.Study Registration: EUDAMED no. CIV-21-09-037762.
Cerebellar functional connectivity change is associated with motor and neuropsychological function in early stage drug-naïve patients with Parkinson’s disease
Authors: Jiang Li , Zhuo Jiachen , Furman Andrew , Fishman Paul S. , Gullapalli Rao 
Published: June 2023

IntroductionParkinson’s Disease (PD) is a progressive neurodegenerative disorder affecting both motor and cognitive function. Previous neuroimaging studies have reported altered functional connectivity (FC) in distributed functional networks. However, most neuroimaging studies focused on patients at an advanced stage and with antiparkinsonian medication. This study aims to conduct a cross-sectional study on cerebellar FC changes in early-stage drug-naïve PD patients and its association with motor and cognitive function.MethodsTwenty-nine early-stage drug-naïve PD patients and 20 healthy controls (HCs) with resting-state fMRI data and motor UPDRS and neuropsychological cognitive data were extracted from the Parkinson’s Progression Markers Initiative (PPMI) archives. We used seed-based resting-state fMRI (rs-fMRI) FC analysis and the cerebellar seeds were defined based on the hierarchical parcellation of the cerebellum (AAL atlas) and its topological function mapping (motor cerebellum and non-motor cerebellum).ResultsThe early stage drug-naïve PD patients had significant differences in cerebellar FC when compared with HCs. Our findings include: (1) Increased intra-cerebellar FC within motor cerebellum, (2) increase motor cerebellar FC in inferior temporal gyrus and lateral occipital gyrus within ventral visual pathway and decreased motor-cerebellar FC in cuneus and dorsal posterior precuneus within dorsal visual pathway, (3) increased non-motor cerebellar FC in attention, language, and visual cortical networks, (4) increased vermal FC in somatomotor cortical network, and (5) decreased non-motor and vermal FC within brainstem, thalamus and hippocampus. Enhanced FC within motor cerebellum is positively associated with the MDS-UPDRS motor score and enhanced non-motor FC and vermal FC is negatively associated with cognitive function test scores of SDM and SFT.ConclusionThese findings provide support for the involvement of cerebellum at an early stage and prior to clinical presentation of non-motor features of the disease in PD patients.
NASAFYTOL® supplementation in adults hospitalized with COVID-19 infection: results from an exploratory open-label randomized controlled trial
Authors: Gérain Jean , Uebelhoer Melanie , Costes Bérénice , Herman Julie , Pietri Sandra , Donneau Anne-Françoise , Monseur Justine , Henrotin Yves 
Published: June 2023

ObjectivesThe effect and safety of Nasafytol®, a food supplement combining curcumin, quercetin, and Vitamin D, on hospitalized COVID-19-positive patients as support to standard of care were to be assessed.MethodsThis exploratory, open-label, randomized, controlled trial was carried out among hospitalized adults with COVID-19 infection. Participants were randomly assigned to receive Nasafytol® or Fultium® control. The improvement of the clinical condition and occurrence of (serious) adverse events were evaluated. The study was registered on clincaltrials.gov with the identifier NCT04844658.ResultsTwenty-five patients received Nasafytol®, and 24 received Fultium®. Demographic characteristics were well balanced between the groups. On day 14 (or at hospital leave if &lt; 14 days), no difference was observed between groups regarding their clinical condition, fever, or the need of oxygen therapy. At day 7, however, 19 participants had been discharged from the hospital in the Nasafytol® arm compared to 10 participants in the Fultium® arm. No participants were transferred to the ICU or died in the Nasafytol® arm, vs. 4 transfers and 1 death in the Fultium® arm. The clinical condition of participants in the Nasafytol® arm had improved, as evidenced by a decrease in the COVID-19 WHO score. Interestingly, five SAEs occurred with Fultium®, while no SAE was observed with Nasafytol®.ConclusionSupplementation with Nasafytol®, in addition to standard-of-care treatment, led to a faster discharge from the hospital, improved clinical conditions of participants, and a reduced risk of serious outcomes, including transfer to the intensive care unit or death, in patients hospitalized with COVID-19.
Screening for early warning of psychological crisis and intervention in children aged 8–18 years with cancer: a historical controlled trial
Authors: Yu Lu , Mo Lin , Liu Yixuan , Huang Xiaoyan 
Published: June 2023

BackgroundChildhood cancer is becoming an emerging healthcare issue in mainland China. Extensive evidence in the literature has demonstrated that cancer and its treatment experience can cause psychological distress that can lead to developmental problems in children with cancer. This study aims to screen for early warning of psychological crisis in children aged 8–18 years with cancer, establish a model of early warning intervention for children with cancer, and explore its application effects.MethodsWe recruited 345 children with cancer and aged 8–18 years as the study participants, of whom 173 children were selected as historical controls during the period between December 2019 and March 2020 and 172 children were selected as the intervention group during the period between July 2020 and October 2020. The routine nursing model was adopted for the control group, and the early warning and intervention model was applied for the intervention group. The early warning and intervention model consisted of four stages: (1) establishing a management team to assess the risk of psychological crisis, (2) developing a three-level early warning response mechanism, (3) developing specific response plans, and (4) creating an evaluation summary and optimization mode. The DASS-21 was used to evaluate the psychological status of children with cancer before and 3 months after the intervention.ResultsThe average age of the control group was 11.43 ± 2.39 years, with 58.96% boys and 61.27% diagnosed with leukemia. The average age of the intervention group was 11.62 ± 2.31 years, with 58.72% boys and 61.63% diagnosed with leukemia. There was a significant reduction in depressive symptoms (4.91 ± 3.98, t = 12.144, P &lt; 0.05), anxiety symptoms (5.79 ± 4.34, t = 8.098, P &lt; 0.05), and stress symptoms (6.98 ± 4.67, t = 11.22, P &lt; 0.05) in the intervention group. The incidence rates of depression, anxiety, and stress were significantly lower in the intervention group (12.79%, 29.07%, and 5.23%, respectively) than in the control group (46.82%, 49.71%, and 27.17%, respectively) (all P's &lt; 0.05).ConclusionsOur study suggests that the early detection and timely management of psychological symptoms through a nursing intervention model can effectively reduce depressive, anxiety, and stress symptoms in Chinese children with cancer. Future work should include conducting qualitative interviews to understand the psychological experiences of children with cancer throughout their entire life cycle.
Clinical analysis and medium-term follow-up of simultaneous interventional therapy for compound congenital heart disease in children: a single-center retrospective study
Authors: Ran Tingting , Feng Lingxin , Li Mi , Yi Qijian , Zhu Xu , Ji Xiaojuan 
Published: June 2023

ObjectiveThis study aimed to explore the safety and efficacy of simultaneous interventional therapy for compound congenital heart disease (CCHD) in children.MethodsIn total, 155 children with CCHD who received simultaneous interventional therapy at the Children's Hospital of Chongqing Medical University between January 2007 and December 2021 were included in study. Data on clinical manifestations, transthoracic echocardiography, electrocardiogram, and follow-up were retrospectively analyzed.ResultsThe most common type of CCHD was atrial septal defect (ASD) combined with ventricular septal defect (VSD), accounting for 32.3% of the patients. Simultaneous interventional therapy was successfully administered to 151 children (97.4%). The pulmonary gradient of patients with pulmonary stenosis decreased from 47.3 ± 21.9 mmHg to 15.2 ± 12.2 mmHg (P &lt; 0.05) immediately after the procedure. One patient had failed PBPV as he had residual PS &gt;40 mmHg post procedure. The right ventricular dimension and left ventricular end-diastolic dimension significantly decreased in the first month after the procedure in patients with ASD combined with VSD. Twenty-five (16.1%) patients had mild residual shunt, which spontaneously disappeared in more than half of these patients 6 months after the procedure. The major adverse events were minimal (n = 4, 2.58%), including one patient requiring drug treatment for complete atrioventricular block and three patients receiving surgical treatment because of cardiac erosion, anterior tricuspid valve chordae rupture, and hemolysis, respectively.ConclusionsASD combined with VSD is the most common type of CCHD in children, and simultaneous interventional therapy for CCHD in children is safe and effective with satisfactory results. Ventricular remodeling can be reversed in patients with ASD combined with VSD 1 month after the procedure. Most adverse events associated with interventional therapy are mild and manageable.
Cognition, prior aggression, and psychopathic traits in relation to impaired multimodal emotion recognition in psychotic spectrum disorders
Authors: Högman Lennart , Gavalova Gabriela , Laukka Petri , Kristiansson Marianne , Källman Malin V. , Fischer Hakan , Johansson Anette G. M. 
Published: June 2023

BackgroundPsychopathic traits have been associated with impaired emotion recognition in criminal, clinical and community samples. A recent study however, suggested that cognitive impairment reduced the relationship between psychopathy and emotion recognition. We therefore investigated if reasoning ability and psychomotor speed were impacting emotion recognition in individuals with psychotic spectrum disorders (PSD) with and without a history of aggression, as well as in healthy individuals, more than self-rated psychopathy ratings on the Triarchic Psychopathy Measure (TriPM).MethodsEighty individuals with PSD (schizophrenia, schizoaffective disorder, delusional disorder, other psychoses, psychotic bipolar disorder) and documented history of aggression (PSD+Agg) were compared with 54 individuals with PSD without prior aggression (PSD-Agg) and with 86 healthy individuals on the Emotion Recognition Assessment in Multiple Modalities (ERAM test). Individuals were psychiatrically stable and in remission from possible substance use disorders. Scaled scores on matrix reasoning, averages of dominant hand psychomotor speed and self-rated TriPM scores were obtained.ResultsAssociations existed between low reasoning ability, low psychomotor speed, patient status and prior aggression with total accuracy on the ERAM test. PSD groups performed worse than the healthy group. Whole group correlations between total and subscale scores of TriPM to ERAM were found, but no associations with TriPM scores within each group or in general linear models when accounting for reasoning ability, psychomotor speed, understanding of emotion words and prior aggression.ConclusionSelf-rated psychopathy was not independently linked to emotion recognition in PSD groups when considering prior aggression, patient status, reasoning ability, psychomotor speed and emotion word understanding.
Family function and anxiety among junior school students during the COVID-19 pandemic: a moderated mediation model
Authors: Guo Zhifang , Zhao Juan , Peng Jiani 
Published: June 2023

BackgroundThe prevalence of anxiety among adolescents is relatively high during an epidemic. Studies have reported that family function and perceived stress are important factors affecting adolescents’ anxiety. However, only few studies have explored the factors influencing the relationship between family function and anxiety. Therefore, this study explored the mediating and moderating mechanisms underlying this relationship among junior school student during the COVID-19 pandemic.Methods745 junior school students completed family function, perceived stress, and anxiety questionnaires.Results(1) The junior school students that were left-behind tended to show lower family function (t = −4.21, p &lt; 0.001), greater perceived stress (t = 2.72, p &lt; 0.01), and higher anxiety (t = 4.24, p &lt; 0.001), (2) Family function in junior school students was negatively associated with anxiety (r = −0.35, p &lt; 0.001); perceived stress mediated the relationship between family function and anxiety (p &lt; 0.001), and (3) Whether the student was left-behind (LB) moderated the link between family function and anxiety (β = −0.16, t = −3.33, p &lt; 0.001) and between family function and perceived stress (β = −0.22, t = −2.61, p &lt; 0.001).ConclusionThese findings suggest a negative association between family function and anxiety. Knowledge of the mediating role of perceived stress and moderating role of being left-behind may help prevent and improve anxiety among junior school students during the COVID-19 pandemic.