bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multicenter randomized phase III trial of dose-dense methotrexate, vinblastine, doxorubicin, and cisplatin (dd-MVAC) or gemcitabine and cisplatin (GC) as perioperative chemotherapy for muscle-invasive bladder cancer (MIBC): Overall survival (OS) data at 5 years in the GETUG/AFU V05 VESPER trial.
Authors: Pfister Christian , Gravis Gwenaelle , Flechon Aude , Chevreau Christine , Mahammedi Hakim , Laguerre Brigitte , Guillot Aline , Joly Florence , Allory Yves , Harter Valentin , Culine Stephane 
Published: June 2023

LBA4507 Background: The optimal perioperative chemotherapy for patients (pts) with muscle-invasive bladder cancer remains open to discussion. The primary endpoint of the VESPER trial (NCT 018 12369) was previously reported with dd-MVAC improved-3 years PFS over GC schedule. In the neoadjuvant group, a better bladder local control and significant difference on 3y-PFS was observed in the dd-MVAC arm (p=0.025). Patients and Methods: Between February 2013 and February 2018, 500 pts were randomized in 28 French centers and received either 4 cycles of GC every 3 weeks or 6 cycles of dd-MVAC every 2 weeks before surgery (neoadjuvant group) or after surgery (adjuvant group). We report the final analysis of the VESPER phase III trial with the overall survival (OS) data after 5 years of follow-up from randomization. Results: 437 pts (88%) received neoadjuvant chemotherapy, 60% of patients received the planned 6 cycles in the dd-MVAC arm, 84% received 4 cycles in the GC arm, thereafter 91% and 90% of patients underwent surgery, respectively. Final median of follow-up was 5 years and 3 months and 190 deaths were reported within 5 years of follow-up. OS at 5 years was improved in the dd-MVAC arm (64% vs 56%, HR=0.77 (95% CI, 0.58-1.03), p=0.078), as was also disease-specific survival (DSS) (5-year rate: 72% vs 59%, HR=0.63 (95% CI, 0.46-0.86), p=0.004). The main cause of death was bladder cancer progression (83%), other causes included cardio-vascular events (4.2%), toxic deaths (2.1%), second cancers (2.1%), others (4.7%) and undocumented deaths (4.2%). In the neoadjuvant group, OS was significantly superior in the dd-MVAC arm (5-year rate: 66% vs 57%, HR=0.71 (95% CI, 0.52-0.97), p=0.032) as well as DSS (5-year rate: 75% vs 60%, HR=0.56 (95% CI, 0.39-0.80), p=0.001). In the adjuvant group, the results were not conclusive due to the limited sample size (n=56).Conclusions: Dose-dense MVAC provided a better OS at 5 years and improved significantly DSS over GC in the peri-operative setting of MIBC. Clinical trial information: NCT01812369 .
Long-term Recurrence Rates After Surgery in Primary Hyperparathyroidism
Authors: Zaman Muizz , Raveendran Laxshika , Senay Ayla , Sayles Harlan , Acharya Runa , Dhir Mashaal 
Published: June 2023

Abstract

Context
Primary hyperparathyroidism (PHPT) is the most common cause of hypercalcemia, yet long-term (5- and 10-year) recurrence rates after curative surgery have been unclear.

Objective
To perform the first systematic review and meta-analysis investigating the long-term recurrence rates of sporadic PHPT after successful parathyroidectomy.

Methods
A comprehensive search of multiple databases (including PubMed, EMBASE, Cochrane, EBSCO-CINHAL, EMBASE, Ovid, Scopus, and Google Scholar) was performed from each database's inception to January 18, 2023. Observational studies reporting at least 5 years of follow-up data after surgical resection were included. Two reviewers independently screened articles for relevance. Of 5769 articles initially identified, 242 were examined in full-text review and 34 were deemed eligible for inclusion. Two authors independently performed data extraction and study appraisal, using the National Institutes of Health study quality assessment tools.

Results
Of 30 658 participants, 350 patients (1.1%) experienced recurrence after resection. A meta-analysis of proportions was performed to obtain the pooled recurrence rates. The pooled estimate for overall recurrence rate was 1.56% (95% CI 0.96-2.28%; I2 = 91%). The pooled estimates for 5- and 10-year recurrence rate after resection were 0.23% (0.04-0.53%, 19 studies; I2 = 66%) and 1.03% (0.45-1.80%, 14 studies; I2 = 89%), respectively. Sensitivity analyses did not find a statistically significant difference when adjusting for study size, diagnosis, or surgical approach.

Conclusion
Approximately 1.56% of sporadic PHPT patients eventually develop recurrence following parathyroidectomy. The initial diagnosis and procedure type does not influence recurrence rates. Consistent long-term follow-up is warranted to help identify recurrent disease.
That Anti-racist Feeling
Authors: Feldman Leah 
Published: June 2023

Abstract
This article traces the devolution of Soviet anti-racism and the emergence of ethnonationalist violence amid the collapse of the Soviet Union. Through an analysis of Uzbek writer Hamid Ismailov’s novel Mbobo/The Underground (2009), it explores the contradictions of Soviet anti-racism at the interface of flesh and place, metaphor and materiality, ecology and affect—contradictions manifested in the ways in which Brown and Black bodies were mapped onto the triumphalist architecture of socialist internationalism. Attending to built infrastructures—metro stations, sports arenas, concert halls, and conference venues—and the bodies of visibly marked internal and international others who constructed, inhabited and moved through these spaces, it discusses how these bodies were conscripted in the material manifestation of socialist internationalism and then made the targets of racialized violence in the waning days of the Soviet Union.
Families and Women in Alfred Marshall's Analysis of Well-Being and Progress
Authors: Gouverneur Virginie 
Published: June 2023

Abstract
Some commentators state that Marshall conceptualizes well-being primarily in terms of the consumer's and producer's surpluses, whose interdependence with moral character rests on the ability of markets to produce their effects on character spontaneously. The purpose of the present article is to show that evolutionary faith is not really enough to remove the tension between the economic and moral dimensions of Marshall's definition of well-being. Marshall understands that progress would not happen without assigning a special role to families and women in cultivating family affections as an essential means of harmonizing these two dimensions. To prove this point, the article examines several economic texts written before Marshall's major economic treatise, Principles of Economics, the first edition of which appeared in 1890. These texts have received little consideration in the existing literature about Marshall's treatment of the role of women in society. Yet they prefigure and allow a better understanding of the theory later expounded in Principles, apprehended here as the fruit of a long process of maturation that continues throughout revisions made in the successive editions of the book.
Orthobiologic Treatment of Throwing Related Injuries in Sport: A Focused Review of the Published Literature
Authors: Bowers Robert L. , Fryar Caroline M. , Cipriano Kevin , Zaremski Jason L. 
Published: June 2023

AbstractBecause of the growth and development of orthobiologics, in particular platelet-rich plasma, as a potential treatment modality in sports related injuries, it is imperative that providers are aware of the up-to-date published data on the usage of this treatment. While some data are promising, prospective studies are needed to determine the effectiveness of platelet-rich plasma treatment for throwing related injuries. There are limitations with all of the published data that include their retrospective nature, heterogeneity between study designs, and platelet-rich plasma characteristics if reported. While platelet-rich plasma may be used as a likely safe adjuvant to conservative and surgical treatments, prospective randomized controlled studies using appropriately reported platelet-rich plasma concentrations and characteristics will help physicians make more definitive recommendations in regard to platelet-rich plasma treatment. Based on the currently available published data, this treatment may be trialed in the right setting and based on severity and location of injury.
First Metatarsophalangeal Joint Pain in Athletes: Diagnosis, Management, and Return to Play Considerations
Authors: Lim Sara , Liem Brian 
Published: June 2023

Abstract
The first metatarsal-phalangeal joint plays a key role for athletes of various disciplines. When an athlete presents for evaluation of pain at this joint, there are several causes that should be considered. The purpose of this article is to review common injuries including turf toe, sand toe, extensor and flexor hallucis longus tendinopathy, sesamoiditis, and metatarsalgia and provide current evidence-based recommendations for diagnosis, management, and return to play considerations. Conditions not specific to athletes like gout and hallux rigidus also are discussed. Mechanism of injury, physical examination, and imaging such as weight-bearing radiographs and point-of-care ultrasound can help with diagnosis. Treatment of many of these injuries begins with nonsurgical management strategies including footwear or activity modification, physical therapy, and select interventions.
Care of the Esports Athlete
Authors: Law Adrienne , Ho Garry , Moore Melita 
Published: June 2023

Abstract
The growth of electronic sports (esports), or competitive video gaming, in recent years has led to an increasing number of players seeking care for injuries and injury prevention associated with esports. In addition, the increase of esports players seeking care from health care professionals leads to a heightened awareness about the role of health and lifestyle in esports performance.
Unfortunately, few health care professionals are familiar with the physical and mental demands of this sport or are comfortable addressing the needs of this athletic population and the issues that they encounter affecting their health and their sport. This article offers an overview of common esports health issues and considerations specific to esports athletic care for the sports medicine physician in support of optimizing the care of these patients.
Demographic, Clinical, and Psychosocial Predictors of Exercise Adherence: The STRRIDE Trials
Authors: Collins Katherine A. , Huffman Kim M. , Wolever Ruth Q. , Smith Patrick J. , Ross Leanna M. , Siegler Ilene C. , Jakicic John M. , Costa Paul T. , Kraus William E. 
Published: June 2023

ABSTRACT

Purpose
This study aimed to identify baseline demographic, clinical, and psychosocial predictors of exercise intervention adherence in the Studies of Targeted Risk Reduction Intervention through Defined Exercise (STRRIDE) trials.

Methods
A total of 947 adults with dyslipidemia or prediabetes were enrolled into an inactive control group or 1 of 10 exercise interventions with doses of 10–23 kcal·kg−1·wk−1, intensities of 40%–80% of peak oxygen consumption, and training for 6–8 months. Two groups included resistance training. Mean percent aerobic and resistance adherence were calculated as the amount completed divided by the prescribed weekly minutes or total sets of exercise times 100, respectively. Thirty-eight clinical, demographic, and psychosocial measures were considered for three separate models: 1) clinical + demographic factors, 2) psychosocial factors, and 3) all measures. A backward bootstrapped variable selection algorithm and multiple regressions were performed for each model.

Results
In the clinical and demographic measures model (n = 947), variables explained 16.7% of the variance in adherence (P < 0.001); lesser fasting glucose explained the greatest amount of variance (partial R
2 = 3.2%). In the psychosocial factors model (n = 561), variables explained 19.3% of the variance in adherence (P < 0.001); greater 36-Item Short Form Health Survey (SF-36) physical component score explained the greatest amount of variance (partial R
2 = 8.7%). In the model with all clinical, demographic, and psychosocial measures (n = 561), variables explained 22.1% of the variance (P < 0.001); greater SF-36 physical component score explained the greatest amount of variance (partial R
2 = 8.9%). SF-36 physical component score was the only variable to account for >5% of the variance in adherence in any of the models.

Conclusions
Baseline demographic, clinical, and psychosocial variables explain approximately 22% of the variance in exercise adherence. The limited variance explained suggests that future research should investigate additional measures to better identify participants who are at risk for poor exercise intervention adherence.
HbA1c Reduction in Diabetic Older Blacks and Hispanics: A Study on Mobile Physical Activity Tracking
Authors: Wu Helen , Ruaño Gualberto , Wang Biju , Grady James J. , Murray Marsha M. , Slivinsky Michelle D. , Laurencin Cato T. 
Published: June 2023

ABSTRACT

Introduction/Purpose
Diabetes is a leading cause of morbidity and mortality and is more prevalent in Blacks and Hispanics. This study aims to examine if different physical activity (PA) intensities reduced hemoglobin A1c (HbA1c) in Blacks and Hispanics with type 2 diabetes mellitus (DM2).

Methods
This pilot study used a one-sample pre- and postintervention design, including four in-person visits during a period of 3 months from January 2018 to December 2020 in Black or Hispanic populations with DM2 in the Greater Hartford, Connecticut, area. At each in-person visit HbA1c; specific, measurable, achievable, realistic, and time-bound goals; and daily PA (categorized into high-, moderate-, or low-intensity levels by a Fitbit® Charge 2) were obtained. Change scores for minutes engaged in each PA level and HbA1c values were created between visits. A linear mixed model was used to analyze these relationships over time.

Results
Among 17 completed participants, mean age was 56 yr, 11 were Black, 6 were Hispanic, 13 were female, and 4 were male. At baseline, mean body mass index was 34.8 kg·m−2 and mean systolic/diastolic blood pressure was 135/81 mm Hg. From 70.2 mmol·mol−1 at baseline, HbA1c decreased to 66.3 after 4 wk, 66.0 after 8 wk, and 63.5 by 12 wk (9.5% reduction, P < 0.05). Average daily PA time increased over 3 months from 15.8 to 20.3 (P = 0.04) to 20.8 (P = 0.02) minutes for moderate-intensity PA (P = 0.05), and from 12.1 to 13.6 (P = 0.08) to 15.2 (P = 0.01) minutes for high-intensity PA. PA increases were significantly associated with an overall 0.58% reduction of HbA1c (P = 0.04).

Conclusion
Guided by carefully selected, evidenced-based behavioral change strategies, this study found that increases of ~7 min of moderate- or high-intensity daily PA were associated with ~10% decrease in HbA1c in Blacks and Hispanics with DM2. This is consistent with the current consensus statement from the American College of Sports Medicine.
TRANSFORMATION OF THE TRANSPORT SERVICES MARKET IN RUSSIA UNDER INTERNATIONAL SANCTIONS
Authors: Pokrovskaya Oksana D. , Moroz Yulia A. , Melikov Marat I. 
Published: June 2023

Background. The paper is devoted to the study of trends in the transformation of the transport services market under the influence of international sanctions. It is shown that the functioning of the Russian transport industry is significantly influenced by external factors - constraints that determine the reorientation of logistics chains. The experience of other countries whose economies operate under international sanctions has been studied.
Materials and/or research methods. Materials from open Internet sources, methods of system analysis, theory of synergetics, process approach were used.
Results. The main directions and results of the transformation of the market of transport services and, in particular, rail transportation are presented. The classification of international sanctions is considered.
Conclusion. According to the results of the study, it was found that the trends in the development of the transport services market that contribute to overcoming barriers to its path are: the development of the PL services market; collaboration of services; the departure of “gray” players; market consolidation (consolidation of carriers); reorientation of carriers to the domestic market and the countries of the Asia-Pacific region; development the North-South corridor (China and Kazakhstan as transit countries).
Value of Algorithm-Enabled Process Innovation: The Case of Sepsis
Authors: Adjerid Idris , Ayvaci Mehmet U. S. , Özer Özalp 
Published: June 2023

Problem definition: Algorithm-enabled decision support has an increasingly important role in supporting the day-to-day operations of healthcare organizations. Yet, fully realizing the value of algorithmic decision support lies critically in the opportunity to re-engineer the related processes and redefine roles in ways that make organizations more effective. We study how and when algorithm-enabled process innovation (AEPI) creates value in light of dynamic operational environments (i.e., workload) and behavioral responses to algorithmic predictions (i.e., algorithmic accuracy). Our context is an AEPI effort around a rule-based decision-support algorithm for early detection of sepsis—a costly condition that is the leading cause of death for hospitalized patients. We collaborated with a large U.S.-based hospital system and examined whether AEPI developed for sepsis care (sepsis AEPI) impacts patient mortality and when this impact is stronger or weaker. Methodology/results: We utilize a rich set of clinical and nonclinical data in empirically examining the impact of sepsis AEPI on patient mortality. We leverage the staggered implementation of sepsis AEPI across hospital units and conduct our estimation on a carefully matched sample. The matching utilizes data on patient vitals and the logic behind the algorithm to create a robust comparison group consisting of patient visits for which sepsis AEPI would have triggered an alert if it had been in place. Our empirical analysis shows that sepsis AEPI reduces the likelihood of death from sepsis (45% relative reduction in mortality risk due to sepsis). A higher-than-usual workload and an increase in the average number of inaccurate alert experience at a hospital unit (e.g., an oncology unit, which provides care for cancer patients), in general, reduces the effectiveness of AEPI. We also identify diminishing mortality benefits over prolonged periods of adoption; evaluation of the moderators over time helps explain this diminishing impact. Managerial implications: Our findings suggest that streamlining sepsis-care processes through a predictive algorithm (i.e., algorithm-based monitoring of real-time patient data and providing predictions, streamlined communication channels for coordinating care for a patient with sepsis prediction, and a more standardized process for sepsis diagnosis and treatment) can reduce the loss of life from sepsis. For the 3,739 sepsis patients in our study period, AEPI’s benefits would translate to 181 lives saved. We show that such value, however, is sensitive to operational and behavioral factors as the algorithm becomes a routine part of the day-to-day operations of the hospital. Funding: Financial support from University Hospitals is gratefully acknowledged. Supplemental Material: The online appendix is available at https://doi.org/10.1287/msom.2023.1226 .
Infant and young child feeding practices and associated socioeconomic and demographic factors among children aged 6–23 months in Ghana: Findings from Ghana Multiple Indicator Cluster Survey, 2017–2018
Authors: Akanbonga Samson , Hasan Tanvir , Chowdhury Uzzal , Kaiser Adrita , Akter Bonny Fatema , Lim Ignitius Ezekiel , Mahmud Ilias 
Published: June 2023

Background
Association between poor infant and young child feeding (IYCF) practices and malnutrition in infants and young children (IYC) is well established. Furthermore, appropriate IYCF practices are important during the first 1,000 days of life to ensure optimal health and development. Understanding IYCF practices and associated socioeconomic and demographic factors will inform interventions to achieve the UN 2030 Sustainable Development Goal (SDG) target to end malnutrition in all forms.

Objective
This study estimates the prevalence of Minimum Dietary Diversity (MDD), Minimum Meal Frequency (MMF), and Minimum Acceptable Diet (MAD), and examines their association with socioeconomic and demographic characteristics among children aged 6–23 months in Ghana.

Method
We used data from the Ghana Multiple Indicator Cluster Survey 6 (GMICS6) conducted in 2017–18. Participants were recruited through multi-stage stratified cluster sampling. Information on caregiver’s self-reported breastfeeding status and 24-hour dietary recall of foods IYC were fed with were collected through face-to-face interviews. We estimated the prevalence of MDD, MMF and MAD with a 95% confidence interval (CI). We investigated the socioeconomic and demographic determinants of MDD, MMF and MAD using univariate and multivariable logistic regression analyses.

Findings
Among 2,585 IYC aged 6–23 months, MDD, MMF and MAD were estimated as 25.46%, 32.82% and 11.72% respectively. Age of the IYC, educational status of the mothers/primary caregivers, and resident regions were found to have positive associations with MDD, MMF and MAD. In addition, the richest household wealth index and urban area of residence were found to have significant positive associations with MDD.

Conclusion
We report a low prevalence of MDD, MMF and MAD. Efforts to improve IYCF practices among children aged 6–23 months in Ghana should focus on multi-sectorial approaches including increasing access to formal education, income-generating activities and addressing regional and rural-urban inequity.
Trends in dental care utilisation among the elderly using longitudinal data from 14 European countries: A multilevel analysis
Authors: Kovács Nóra , Liska Orsolya , Idara-Umoren Enoabasi Omonigho , Mahrouseh Nour , Varga Orsolya 
Published: June 2023

BackgroundThe use of dental care among older people is low compared to other forms of health care, with significant health consequences. However, the evidence on the extent to which countries’ welfare systems and socio-economic factors influence the uptake of dental care by older people is limited. This study aimed to describe trends of dental care utilisation, and to compare use of dental care with other types of healthcare services among the elderly, considering different socio-economic factors and welfare systems in European countries.MethodsMultilevel logistic regression analysis was performed using longitudinal data from four waves (between Wave 5 and 8) of the Survey of Health, Ageing and Retirement in Europe database, with a follow-up period of 7 years. The study sample included 20,803 respondents aged 50 years or older from 14 European countries.ResultsThe annual dental care attendance was the highest in Scandinavian countries (85.7%), however, improving trends of dental attendance was recognized in Southern and Bismarckian countries (p<0.001). The difference in use of dental care services between socio-economic groups was expanding over time regarding low- and high-income level and residential area. A more marked difference was observed between social groups in dental care utilisation compared to other forms of care. Income level and unemployed status had significant effect on forgoing dental care due to cost and unavailability.ConclusionThe observed differences between socioeconomic groups may highlight the health consequences of the different organization and financing of dental care. The elderly population could benefit from adopting policies aiming to reduce the financial barriers to dental care usage, especially in Southern and Eastern European countries.