bluuebunny/crossref_metadata_2025_split huggingface dataset:
Magnetically Detachable Pipe Joints: A Possible Ideal Way to Prevent Unplanned Extubation
Authors: Luo Xiaoping , Pei Kexi , Huang Qian , Li Binfei 
Published: January 2023

Introduction Many indwelling drainage tubes after surgery. Due to the characteristics of the implanted end in the body and the tube fixed in the body, once the force is pulled, it is easy to cause extubation events, and the incidence of unplanned extubation is at a high level. And considerable distress to patients. Methods We designed a magnetically controlled separable pipe joint device, which can realize the pipe’s automatic separation and protection function in a critical state, and protect the patient’s pipe from being pulled out when the pipe is affected by an external force. And realize the automatic closing function and automatic alarm function of the broken end after the pipeline is separated, to minimize the occurrence of unplanned extubation. Results The magnetically-controlled separable pipe joint was initially applied to the clinic. Compared with the traditional drainage tube, the incidence of unplanned extubation time can be effectively reduced, and the safety, portability, and maneuverability have been greatly guaranteed. Conclusion The magnetron detachable pipe joint device provides a new idea for selecting clinical drainage tubes by improving the defects of traditional drainage tubes. It can effectively prevent the occurrence of unplanned extubation.
Patient experience of imaging reports: A systematic literature review
Authors: Rogers Charlie , Willis Sophie , Gillard Steven , Chudleigh Jane 
Published: January 2023

Introduction: Written reports are often the sole form of communication from diagnostic imaging. Reports are increasingly being accessed by patients through electronic records. Experiencing medical terminology can be confusing and lead to miscommunication, a decrease in involvement and increased anxiety for patients. Methods: This systematic review was designed to include predefined study selection criteria and was registered prospectively on PROSPERO (CRD42020221734). MEDLINE, CINAHL, Academic Search Complete (EBSCOhost), EMBASE, Scopus and EThOS were searched to identify articles meeting the inclusion criteria. Studies were assessed against the Mixed-Methods Appraisal Tool version 2018 for quality. A segregated approach was used to synthesise data. A thematic synthesis of the qualitative data and a narrative review of the quantitative data were performed, and findings of both syntheses were then integrated. Findings: Twelve articles reporting 13 studies were included. This review found that patients’ experiences of imaging reports included positive and negative aspects. The study identified two main themes encompassing both qualitative and quantitative findings. Patients reported their experiences regarding their understanding of reports and self-management. Discussion: Patient understanding of imaging reports is multi factorial including medical terminology, communication aids and errors. Self-management through direct access is important to patients. While receiving bad news is a concern, responsibility for accessing this is accepted. Conclusion: A patient-centred approach to writing imaging reports may help to improve the quality of service, patient experience and wider health outcomes.
Are physicians and medical students ready for artificial intelligence applications in healthcare?
Authors: AlZaabi Adhari , AlMaskari Saleh , AalAbdulsalam Abdulrahman 
Published: January 2023

Background Artificial intelligence (AI) Healthcare applications are listed in the national visions of some Gulf Cooperation Council countries. A successful use of AI depends on the attitude and perception of medical experts of its applications. Objective To evaluate physicians and medical students’ attitude and perception on AI applications in healthcare. Method A web-based survey was disseminated by email to physicians and medical students. Results A total of 293 (82 physicians and 211 medical students) individuals have participated (response rate is 27%). Seven participants (9%) reported knowing nothing about AI, while 208 (69%) were aware that it is an emerging field and would like to learn about it. Concerns about AI impact on physicians’ employability were not prominent. Instead, the majority (n=159) agreed that new positions will be created and the job market for those who embrace AI will increase. They reported willingness to adapt AI in practice if it was incorporated in international guidelines (30.5%), published in respected scientific journals (17.1%), or included in formal training (12.2%). Almost two of the three participants agreed that dedicated courses will help them to implement AI. The most commonly reported problem of AI is its inability to provide opinions in unexpected scenarios. Half of the participants think that both the manufacturer and physicians should be legally liable for medical errors occur due to AI-based decision support tools while more than one-third (36.77%) think that physicians who make the final decision should be legally liable. Senior physicians were found to be less familiar with AI and more concerned about physicians’ legal liability in case of a medical error. Conclusion Physicians and medical students showed positive attitudes and willingness to learn about AI applications in healthcare. Introducing AI learning objectives or short courses in medical curriculum would help to equip physicians with the needed skills for AI-augmented healthcare system.
The Factors That Influence Chemotherapy Exposure Among Nurses: An Integrative Review
Authors: Abu-Alhaija Dania , Bakas Tamilyn , Shaughnessy Elizabeth , Miller Elaine 
Published: January 2023

Background: Exposure to chemotherapy is an occupational hazard predisposing nurses to severe health effects. The purpose of this integrative review was to identify the recent literature describing the risk factors for occupational exposure to chemotherapy among nurses. Methods: The Preferred Reporting Items for Systematic Reviews and Meta-Analyses methodology was employed to conduct the review. The databases searched were Scopus, PubMed, and CINAHL using the search terms “chemotherapy,” “drugs,” “exposure,” and “nurses.” Included articles were published between January 2010 and February 2022, published in peer-reviewed journals for research conducted in the United States, and written in English language. Excluded articles were studies that did not involve nurses in their samples. Review articles, books, theses, and dissertations were excluded as well. The Johns Hopkins Nursing Evidence-Based Practice Model was used to assess the level of evidence from the reviewed studies. Findings: Fourteen studies were included in this review. Ten studies were rated on Evidence Level III, two on Evidence Level II, one on Evidence Level I, and one on Evidence Level V. The main risk factors for occupational exposure were nurses’ knowledge of chemotherapy handling guidelines, nurses’ adherence to using the personal protective equipment, nurses’ health beliefs regarding chemotherapy exposure, and workplace-related factors such as workload and managerial support. Conclusion: Addressing the identified risk factors would protect nurses from chemotherapy exposure. More research on nurses’ health beliefs regarding chemotherapy exposure and the cues to adhere to chemotherapy handling guidelines in the work environment is needed.
When Should Bony Correction Be Considered in Addition to Medial Patellofemoral Ligament Reconstruction? Results of a Clinically Derived 2-Group Classification of Lateral Patellar Instability Based on 122 Patients at 2- to 5-Year Follow-up
Authors: Zimmermann Felix , Milinkovic Danko Dan , Zimmerer Alexander , Balcarek Peter 
Published: January 2023

Background: The need for concomitant bony procedures to realign pathoanatomic risk factors in addition to medial patellofemoral ligament reconstruction (MPFL-R) remains unclear. Purpose: To evaluate a clinically derived 2-part classification of lateral patellar instability aimed at identifying patients indicated for a concomitant bony procedure. Study Design: Cohort study; Level of evidence, 3. Methods: The study included 122 patients (42 male, 80 female; mean ± SD age, 22 ± 6 years) who were assigned to a mild instability group (mIG) and a complex instability group (cIG) based on the reversed dynamic patellar apprehension test (ReDPAT) and J-sign. The mIG had a positive ReDPAT result <40° to 50° of knee flexion and an absent or low-grade J-sign (grade 1), and the cIG had a positive ReDPAT result >40° of knee flexion and/or a high-grade J-sign (grade 2 or 3). The mIG underwent isolated MPFL-R, and the cIG underwent MPFL-R and concomitant bony procedures depending on the established risk factor assessment. For evaluation, the BANFF Patellar Instability Instrument 2.0 (BPII 2.0) and numeric analog scale (0-10) for patellofemoral pain and subjective knee function were used. The minimal clinically important difference for the BPII 2.0 was ascertained by calculating half the standard deviation of baseline scores. Results: Radiographic analysis confirmed a significantly more pronounced pathoanatomic risk factor constellation in the cIG regarding severity of trochlear dysplasia, distal malalignment, and patellar height (all P < .05). At final follow-up, no patellar redislocation occurred in either group; 2 patients in the cIG reported patellar subluxation. Within both groups, all outcome scores improved significantly pre- to postoperatively (all P < .0001); no between-group difference was found regarding BPII 2.0 score and numeric analog scale for function. The minimal clinically important difference for the BPII 2.0 was met by 84% (32/38) of the mIG and 90% (76/84) of the cIG ( P = .36), but the cIG experienced more patellofemoral pain than the mIG (1.3 ± 1.6 vs 2.1 ± 2.1; P = .036). Conclusion: Patients with a high-grade J-sign and/or a positive ReDPAT finding beyond 40° to 50° of knee flexion exhibited a significantly more pronounced pathoanatomic risk factor constellation; however, the correction of modifiable risk factors led to similarly good outcomes to patients who underwent isolated MPFL-R. A slightly higher level of patellofemoral pain after bony procedures was evident in these patients.
Factor XII contributes to thrombotic complications and vaso-occlusion in sickle cell disease
Authors: Sparkenbaugh Erica M. , Henderson Michael W. , Miller-Awe Megan , Abrams Christina , Ilich Anton , Trebak Fatima , Ramadas Nirupama , Vital Shantel , Bohinc Dillon , Bane Kara L. , Chen Chunsheng , Patel Margi , Wallisch Michael , Renné Thomas , Gruber Andras , Cooley Brian , Gailani David , Kasztan Malgorzata , Vercellotti Gregory M. , Belcher John D. , Gavins Felicity E. , Stavrou Evi X. , Key Nigel S. , Pawlinski Rafal 
Published: January 2023

Abstract
A hypercoagulable state, chronic inflammation, and increased risk of venous thrombosis and stroke are prominent features in patients with sickle cell disease (SCD). Coagulation factor XII (FXII) triggers activation of the contact system that is known to be involved in both thrombosis and inflammation, but not in physiological hemostasis. Therefore, we investigated whether FXII contributes to the prothrombotic and inflammatory complications associated with SCD. We found that when compared with healthy controls, patients with SCD exhibit increased circulating biomarkers of FXII activation that are associated with increased activation of the contact pathway. We also found that FXII, but not tissue factor, contributes to enhanced thrombin generation and systemic inflammation observed in sickle cell mice challenged with tumor necrosis factor α. In addition, FXII inhibition significantly reduced experimental venous thrombosis, congestion, and microvascular stasis in a mouse model of SCD. Moreover, inhibition of FXII attenuated brain damage and reduced neutrophil adhesion to the brain vasculature of sickle cell mice after ischemia/reperfusion induced by transient middle cerebral artery occlusion. Finally, we found higher FXII, urokinase plasminogen activator receptor, and αMβ2 integrin expression in neutrophils of patients with SCD compared with healthy controls. Our data indicate that targeting FXII effectively reduces experimental thromboinflammation and vascular complications in a mouse model of SCD, suggesting that FXII inhibition may provide a safe approach for interference with inflammation, thrombotic complications, and vaso-occlusion in patients with SCD.
Autoimmune hemolytic anemia during pregnancy and puerperium: an international multicenter experience
Authors: Fattizzo Bruno , Bortolotti Marta , Fantini Norma N. , Glenthøj Andreas , Michel Marc , Napolitano Mariasanta , Raso Simona , Chen Frederick , McDonald Vickie , Murakhovskaya Irina , Vos Josephine Mathilde Iris , Patriarca Andrea , Mingot-Castellano Maria Eva , Giordano Giulio , Scarrone Margherita , González-López Tomás José , Trespidi Laura , Prati Daniele , Barcellini Wilma 
Published: January 2023

Abstract
Relapsing or occurring de novo autoimmune hemolytic anemia (AIHA) during pregnancy or puerperium is a poorly described condition. Here, we report 45 pregnancies in 33 women evaluated at 12 centers from 1997 to 2022. Among the 20 women diagnosed with AIHA before pregnancy, 10 had a relapse. An additional 13 patients developed de novo AIHA during gestation/puerperium (2 patients had AIHA relapse during a second pregnancy). Among 24 hemolytic events, anemia was uniformly severe (median Hb, 6.4 g/dL; range, 3.1-8.7) and required treatment in all cases (96% steroids ± intravenous immunoglobulin, IVIG, 58% transfusions). Response was achieved in all patients and was complete in 65% of the cases. Antithrombotic prophylaxis was administered to 8 patients (33%). After delivery, rituximab was administered to 4 patients, and cyclosporine was added to 1 patient. The rate of maternal complications, including premature rupture of membranes, placental detachment, and preeclampsia, was 15%. Early miscarriages occurred in 13% of the pregnancies. Fetal adverse events (22% of cases) included respiratory distress, fetal growth restriction, preterm birth, AIHA of the newborn, and 2 perinatal deaths. In conclusion, the occurrence of AIHA does not preclude the ability to carry out a healthy pregnancy, provided close monitoring, prompt therapy, and awareness of potential maternal and fetal complications.
Single-cell spatial explorer: easy exploration of spatial and multimodal transcriptomics
Authors: Pont Frédéric , Cerapio Juan Pablo , Gravelle Pauline , Ligat Laetitia , Valle Carine , Sarot Emeline , Perrier Marion , Lopez Frédéric , Laurent Camille , Fournié Jean Jacques , Tosolini Marie 
Published: January 2023

Abstract
Background:
The development of single-cell technologies yields large datasets of information as diverse and multimodal as transcriptomes, immunophenotypes, and spatial position from tissue sections in the so-called ’spatial transcriptomics’. Currently however, user-friendly, powerful, and free algorithmic tools for straightforward analysis of spatial transcriptomic datasets are scarce.

Results:
Here, we introduce Single-Cell Spatial Explorer, an open-source software for multimodal exploration of spatial transcriptomics, examplified with 9 human and murine tissues datasets from 4 different technologies.

Conclusions:
Single-Cell Spatial Explorer is a very powerful, versatile, and interoperable tool for spatial transcriptomics analysis.
Circ VRK1/microRNA-17/PTEN axis modulates the angiogenesis of human brain microvascular endothelial cells to affect injury induced by oxygen-glucose deprivation/reperfusion
Authors: Yang Lei , Du Hong , Zhang Xuejing , Gao Bulang , Zhang Dongliang , Qiao Zongrong , Su Xianhui , Bao Tong , Han Siqin 
Published: January 2023

Abstract
Background
Circular RNAs (circRNAs) can act as microRNA (miRNA) sponges, thus regulating gene expression. The role of circRNAs in the process of oxygen-glucose deprivation/reoxygenation (OGD/R) is unclear. Here, we explored the mechanism underlying Circ VRK1 in human brain microvascular endothelial cells (HBMVECs) injury induced by OGD/R.

Methods
The OGD/R cell model was established in HBMVECs. The microarray was applied to detect differentially expressed circRNAs, followed by subcellular fractionation assay. Colony formation assay, flow cytometry, ELISA, tube formation, Transwell and western blot assays were performed for loss-of-function assay. HE staining, TTC staining, immunohistochemistry and western blot were performed in an established mouse model. The relationships between Circ VRK1 and miR-17, and between miR-17 and PTEN were detected by bioinformatics and dual-luciferase assays. Rescue experiments were conducted in vitro and in vivo, and PI3K/AKT activity was detected by Western Blot.

Results
Circ VRK1, predominantly present in the cytoplasm of cells, was upregulated in the HBMVECs exposed to OGD/R. Circ VRK1 downregulation decreased proliferation, migration, tube formation, inflammatory factors and oxidative stress, while increased apoptosis in HBMVECs. Moreover, Circ VRK1 silencing reduced neurological damage, cerebral infarct size, CD34-positive cell counts and VEGF expression in mice. Circ VRK1 mediated PTEN expression and the PI3K/AKT pathway by targeting miR-17. Deletion of miR-17 inhibited the effects of Circ VRK1 siRNA, and silencing of PTEN suppressed the effects of miR-17 inhibitor.

Conclusion
Circ VRK1 was upregulated during OGD/R. Circ VRK1 downregulation regulates PTEN expression by targeting miR-17, thereby promoting PI3K/AKT pathway activity to alleviate OGD/R injury.
Influence of sex, age and diabetes on brain transcriptome and proteome modifications following cerebral ischemia
Authors: Ramiro Laura , Faura Júlia , Simats Alba , García-Rodríguez Paula , Ma Feifei , Martín Luna , Canals Francesc , Rosell Anna , Montaner Joan 
Published: January 2023

AbstractIschemic stroke is a major cause of death and disability worldwide. Translation into the clinical setting of neuroprotective agents showing promising results in pre-clinical studies has systematically failed. One possible explanation is that the animal models used to test neuroprotectants do not properly represent the population affected by stroke, as most of the pre-clinical studies are performed in healthy young male mice. Therefore, we aimed to determine if the response to cerebral ischemia differed depending on age, sex and the presence of comorbidities. Thus, we explored proteomic and transcriptomic changes triggered during the hyperacute phase of cerebral ischemia (by transient intraluminal middle cerebral artery occlusion) in the brain of: (1) young male mice, (2) young female mice, (3) aged male mice and (4) diabetic young male mice. Moreover, we compared each group's proteomic and transcriptomic changes using an integrative enrichment pathways analysis to disclose key common and exclusive altered proteins, genes and pathways in the first stages of the disease. We found 61 differentially expressed genes (DEG) in male mice, 77 in females, 699 in diabetics and 24 in aged mice. Of these, only 14 were commonly dysregulated in all groups. The enrichment pathways analysis revealed that the inflammatory response was the biological process with more DEG in all groups, followed by hemopoiesis. Our findings indicate that the response to cerebral ischemia regarding proteomic and transcriptomic changes differs depending on sex, age and comorbidities, highlighting the importance of incorporating animals with different phenotypes in future stroke research studies.
Neutrophil-to-lymphocyte ratio as a predictor of in-hospital complications and overall mortality in Takotsubo syndrome preceded by physical triggers
Authors: Ahn Hyo-Jeong , Kang Jeehoon , Lee So-Ryoung , Park Jin Joo , Lee Hae-Young , Choi Dong-Ju , Cho Hyun-Jai 
Published: January 2023

Abstract
Background
Takotsubo syndrome (TTS) with physical triggers has worse short- and long-term clinical courses than those with emotional triggers. However, predictive factors associated with poor outcomes of TTS with physical triggers are unknown.

Methods
We included 231 patients identified as TTS preceded by physical triggers at two tertiary referral hospitals from 2010 to 2019. In-hospital complications (IHC)—a composite of malignant arrhythmia, need for mechanical circulatory support or mechanical ventilation, and in-hospital death—and overall mortality were retrospectively reviewed. The associations with clinical features were evaluated by multivariable logistic and Cox regression analyses.

Results
The mean age was 69.3 ± 11.6 years, and 85 (36.8%) were male. The in-hospital complications rate was 46.8%. During a median follow-up of 883 days, 96 (41.6%) had died, and overall mortality was 13.6% per patient-year. Higher neutrophil-to-lymphocyte ratio (NLR) was associated with a higher risk of IHC (area under the receiver operating characteristic curve = 0.73; positive and negative predictive value = 60.9% and 67.2% for NLR ≤ 12); odds ratio (OR) with 95% confidence interval (CI) was 1.03 (1.01–1.05), p = 0.010. Subsequently, higher NLR was also related to a greater risk of overall mortality; patients with high NLR (NLR > 12) exhibited poor long-term survival than those with low NLR (NLR ≤ 5): hazard ratio (95% CI), 3.70 (1.72–7.94) with p < 0.001.

Conclusions
A high NLR at initial presentation is associated with an increased risk of IHC and overall mortality in TTS preceded by physical triggers. Given that the treatment of TTS is mainly supportive, intensive monitoring with careful follow-up would be warranted in patients with high NLR.
Correlation between input on public health services and work motivation among primary health workers in China
Authors: Li Jia , Yu Yahang , Hei Luping , Yuan Beibei 
Published: January 2023

Abstract
Background
The integration of public health services into primary health care has been advocated and practiced worldwide for better management of preventable diseases. Health policy makers in China have started the reforms to better integrate public health services and clinical services, but public health services in China still remained neglected in primary health system. This study aimed to explore the input of Chinese primary health workers on delivering public health services and its association with their intrinsic working motivation in China.

Methods
Data were collected from a cross-sectional survey conducted in 2019. Participants in this survey included 803 primary health workers in 75 primary health institutions in China. Questions about the input on clinical and public health services delivery and intrinsic working motivation were asked. A multiple linear regression model was adopted to investigate the correlation between intrinsic working motivation and the time input on public health service. The robustness of this model was checked with a generalized linear model.

Results
Intrinsic motivation was found to have negative association with health workers’ input on public health (β: -1.01, p < 0.05), with the robustness checked with a generalized linear model. The significance of this association differed in the group of urban community health centers and rural township health center. Other factors that had significant relationship with the input on public health services include the being nurses instead of doctors (p < 0.01), being a member of family doctor team (p < 0.01), recognition on relative importance of clinical services (p < 0.01), and perception on better exterior support (p < 0.01).

Conclusion
With higher intrinsic working motivation, primary health workers tended to spend less time on public health services. It reflected that doctors and nurses in primary healthcare institutions still perceived clinical treatment services as their main work responsibility and source of career recognition. Organizational level supports and system level policies should guide the primary health workers to increase their awareness on the importance of public health services and to cultivate their internal interests on public health services, in order to ensure sustainable input and performance improvement on public health services in primary health system in China.