bluuebunny/crossref_metadata_2025_split huggingface dataset:
Parties, Voters and Political Change in Early Twentieth-Century Manchester: Reconnecting Politics and Society
Authors: Adams Tony 
Published: March 2023

Abstract
In the wake of the linguistic turn the ‘new political history’ has recognized the importance of both political language and social context. In practice, however, over recent years much political history of the pre-1918 period has become increasingly focused on language and party, relegating society and economy to the margins. This study emphasizes the interconnectedness of party politics and society, arguing that smaller municipal electoral districts offer potential new insights into the impact of religion, class, gender and ethnicity upon both, party policy and practice, and voter behaviour. Parties adapted their campaign strategies and policy stances to reflect their understanding of the social make-up of local electorates. Voter responses to party campaigns could be strongly influenced, but not determined, by individual or group perceptions of social standing. By exploring the connected fortunes of all three major parties new light is shed on the development of local political culture before 1914. The article also assesses the shifting strengths and weaknesses of Conservative, Liberal, and Labour parties, and contributes to historiographical debates on the politics of slum and suburban communities, and the pre-war trajectories of the major parties.
Individual Differences in Pain Catastrophizing and Regional Gray Matter Volume Among Community-dwelling Adults With Chronic Pain
Authors: Liu Shuyang , You BeiBei , Zhang Xin , Shaw Amy , Chen Hong , Jackson Todd 
Published: March 2023

Objectives:
Elevations in pain catastrophizing (PC) are associated with more severe pain, emotional distress, and impairment within samples with chronic pain. However, brain structure correlates underlying individual differences in PC are not well understood and predict more severe pain and impairment within samples with chronic pain. This study assessed links between regional gray matter volume (GMV) and individual differences in PC within a large mixed chronic pain sample.

Materials and Methods:
Chinese adult community dwellers with chronic pain of at least 3 months duration (101 women and 59 men) completed self-report measures of background characteristics, pain severity, depression, and a widely validated PC questionnaire as well as a structural magnetic resonance imagining scan featuring voxel-based morphology to assess regional GMV correlates of PC.

Results:
After controlling for demographic correlates of PC, pain severity, and depression, higher PC scores had a significant, unique association with lower GMV levels in the inferior temporal area of the right fusiform gyrus, a region previously implicated in emotion regulation.

Discussion:
GMV deficits, particularly in right temporal-occipital emotion regulation regions, correspond to high levels of PC among individuals with chronic pain.
Is Severe Neck Pain a Contraindication to Performing Laminoplasty in Patients With Cervical Spondylotic Myelopathy?
Authors: Pinter Zachariah W. , Mikula Anthony L. , Reed Ryder , Lakomkin Nikita , Townsley Sarah E. , Wright Breydan , Kazarian Erick , Michalopoulos Giorgos D. , Currier Bradford , Freedman Brett A. , Bydon Mohamad , Elder Benjamin D. , Fogelson Jeremy , Sebastian Arjun S. , Nassr Ahmad 
Published: March 2023

Study Design:
Retrospective review.

Objective:
The purpose of this study was to investigate the surgical outcomes in a cohort of patients with severe preoperative axial neck pain undergoing laminoplasty for cervical spondylotic myelopathy (CSM).

Summary of Background Data:
No study has investigated whether patients with severe axial symptoms may achieve satisfactory neck pain and disability outcomes after laminoplasty.

Methods:
We performed a retrospective review of 91 patients undergoing C4-6 laminoplasty for CSM at a single academic institution between 2010 and 2021. Patient-reported outcome measures (PROMs), including Neck Disability Index (NDI), visual analog scale (VAS) Neck, and VAS Arm, were recorded preoperatively and at 6 months and 1 year postoperatively. Patients were stratified as having mild pain if VAS neck was 0–3, moderate pain if 4–6, and severe pain if 7–10. PROMs were then compared between subgroups at all the perioperative time points.

Results:
Both the moderate and severe neck pain subgroups demonstrated a substantial improvement in VAS neck from preoperative to 6 months postoperatively (−3.1±2.2 vs. −5.6±2.8, respectively; P<0.001), and these improvements were maintained at 1 year postoperatively. There was no difference in VAS neck between subgroups at either the 6-month or 1-year postoperative time points. Despite the substantially higher mean NDI in the moderate and severe neck pain subgroups preoperatively, there was no difference in NDI at 6 months or 1 year postoperatively (P=0.99). There were no differences between subgroups in the degree of cord compression, severity of multifidus sarcopenia, sagittal alignment, or complications.

Conclusions:
Patients with moderate and severe preoperative neck pain undergoing laminoplasty achieved equivalent PROMs at 6 months and 1 year as patients with mild preoperative neck pain. The results of this study highlight the multifactorial nature of neck pain in these patients and indicate that severe axial symptoms are not an absolute contraindication to performing laminoplasty in well-aligned patients with CSM.
Flare and change in disease activity among patients with stable rheumatoid arthritis following coronavirus disease 2019 vaccination: a prospective Chinese cohort study
Authors: Geng Yan , Fan Yong , Wang Yu , Deng Xuerong , Ji Lanlan , Zhang Xiaohui , Song Zhibo , Huang Hong , Gui Yanni , Zhang Haoze , Sun Xiaoying , Li Guangtao , Zhao Juan , Zhang Zhuoli 
Published: March 2023

Abstract

Background:
Vaccination has been shown effective in controlling the global coronavirus disease 2019 (COVID-19) pandemic and reducing severe cases. This study was to assess the flare and change in disease activity after COVID-19 vaccination in patients with stable rheumatoid arthritis (RA).

Methods:
A prospective cohort of RA patients in remission or with low disease activity was divided into a vaccination group and a non-vaccination group based on their COVID-19 vaccination status. Each of them was examined every 3 to 6 months. In the vaccination group, disease activity was compared before and after vaccination. The rates of flare defined as disease activity scores based on 28-joint count (DAS28) >3.2 with ΔDAS28 ≥0.6 were compared between vaccination and non-vaccination groups.

Results:
A total of 202 eligible RA patients were enrolled. Of these, 98 patients received no vaccine shot (non-vaccination group), and 104 patients received two doses of vaccine (vaccination group). The median time interval from pre-vaccination visit to the first immunization and from the second dose of vaccine to post-vaccination visit was 67 days and 83 days, respectively. The disease activity scores at pre-vaccination and post-vaccination visits in the vaccination group patients were similar. At enrollment, gender, RA disease course, seropositivity, and disease activity were comparable across the two groups. Flare was observed in five (4.8%) of the vaccination group patients and nine (9.2%) of the non-vaccination group patients at post-vaccination assessment (P = 0.221). In terms of safety, 29 (27.9%) patients experienced adverse events (AEs) after vaccination. No serious AEs occurred.

Conclusions:
COVID-19 vaccinations had no significant effect on disease activity or risk of flare in RA patients in remission or with low disease activity. Patients with stable RA should be encouraged to receive the COVID-19 vaccination.
Felix von Bärensprung—A Review of His Life and Work on the Occasion of His 200th Birthday
Authors: Weyers Wolfgang 
Published: March 2023

Abstract:
Felix von Bärensprung was a pioneer of dermatopathology. His monograph of 1848, “Contributions to the Anatomy and Pathology of the Human Skin,” was one of the first publications on that subject. Von Bärensprung also described and named erythrasma, elucidated the pathogenesis of herpes zoster, contributed a comprehensive review of the history of dermatology in an unfinished textbook of skin diseases, and was coauthor, together with Ferdinand Hebra of Vienna, of one of the most influential clinical atlases in the history of dermatology. The 200th anniversary of his birthday in 2022 provides an occasion for reminding of one of the leading dermatologists of the mid 19th century.
Pagetoid Spread in Basal Cell Carcinoma: Potential for Misdiagnosis
Authors: Khurana Maya , Mandal Ria , Cassarino David S. 
Published: March 2023

Abstract:
Basal cell carcinomas are one of the most common cutaneous carcinomas and show classical histologic features of basaloid nests with peripheral palisading. Pagetoid and intraepidermal spread has not been described in basal cell carcinoma to the best of our knowledge. We report 5 cases of basal cell carcinoma with classic histologic patterns and overlying basaloid nests and single intraepidermal tumor cells. A panel of immunostains were performed that included CK7, MOC31, CEA-m, EMA, androgen receptor, and Bcl2. Most of our cases were positive for both MOC31 and CK7, and all cases were negative for CEA-m and EMA excluding extramammary Paget disease, one of the most common differential diagnoses. These cases expand the spectrum of findings that can be seen in basal cell carcinoma and can help prevent misdiagnoses of basal cell carcinomas as more aggressive tumors.
Clinical Features of Pediatric Age Herpes Simplex Virus Keratitis
Authors: Ulman Elif Akbas , Selver Ozlem Barut , Biler Elif Demirkilinc , Palamar Melis 
Published: March 2023

Purpose:
The objective of this study is to evaluate the clinical features of pediatric herpes simplex virus keratitis, its recurrence rates, and its effects on visual acuity.

Methods:
In this retrospective case series, records of pediatric patients (0–16 years) who presented with herpes simplex virus keratitis between January 2012 and September 2021 were evaluated. Data including age, gender, additional systemic diseases, the number of recurrences, recurrence time, treatment protocol, follow-up period, and presence of amblyopia were reviewed.

Results:
Twenty-four patients (16 females and 8 males) with a mean age of 6.6 ± 4 (1.1–15) years were included in the study. The mean follow-up time was 21 ± 19.9 (7–94) months. Four patients (16.6%) had bilateral keratitis. Including all 4 patients with bilateral involvement, a total of 10 (41.6%) patients had additional systemic diseases that cause immunodeficiency. After prophylactic antiviral treatment for at least 6 months (except for isolated epithelial keratitis), recurrence was detected in 5 (22.7%) patients, who were all immunodeficient. Among immunodeficient individuals, the recurrence rate was found to be 50%. Keratitis recurrence was significantly associated with immunodeficiency (P = 0.03). However, type of keratitis (P = 0.42), gender (P = 0.47), and bilaterality (P = 0.54) were not related with recurrence. 66.7% of the patients younger than 10 years developed amblyopia during follow-up.

Conclusions:
In childhood, the most frequent corneal manifestation of herpes simplex virus is stromal keratitis that mostly progresses with corneal scarring, residual astigmatism, and amblyopia. The recurrence rate increases in the presence of immunosuppression. Close follow-up, rapid diagnosis, and treatment are critical for battling against amblyopia and achieving good visual prognosis.
Nonlinear Relationship Between C-Reactive Protein and Depression Among Obese Middle-Aged Adults
Authors: Lee Chiyoung , Min Se Hee , Niitsu Kosuke 
Published: March 2023

Abstract

Background
Despite the agreement on the significance of the relationship between the C-reactive protein (CRP) and depression, research results have been discrepant by gender.

Objective
We attempted to address this uncertainty via a generalized additive model (GAM) and more carefully analyzed the shape of the CRP-depression relationship in terms of sex.

Methods
This is a secondary data analysis using the National Health and Nutrition Examination Survey (2017–2020) data targeting 1,581 obese middle-aged adults (40–70 years; 51.4% women) with CRP ≤ 10 mg/L. The study outcome was depression severity, assessed by the Patient Health Questionnaire-9. Several models were built, adjusting for relevant sociodemographic, lifestyle, and clinical covariates. The value of the effective degree of freedom (EDF) quantifies curvature of the relationship. The threshold effect was investigated using a two-piecewise linear regression model, when needed.

Results
Among men, an increasing linear pattern was found (EDF ≈ 1). Contrastingly among women, the EDF value was >2 in all unadjusted and adjusted models, indicating the smooth (curved) association. The threshold level affected the association pattern particularly for women, among whom the depression severity related to CRP significantly increased as the CRP level increased to an inflection point of 3.6 mg/L but decreased thereafter.

Discussion
Assuming linearity for the CRP association with depression may not be appropriate for middle-aged obese women. While we do not claim to provide a definite method of assessing the CRP-depression relationship, we hope to offer a different perspective when exploring this relationship. Thus, the results should be interpreted cautiously, and future studies on this topic should replicate this approach with GAMs.
Differential Gene Expression Among Patients With Heart Failure Experiencing Pain
Authors: Smith Asa B. , Jung Miyeon , Pressler Susan J. , Mocci Evelina , Dorsey Susan G. 
Published: March 2023

Abstract

Background
Chronic pain is frequently experienced by patients with heart failure (HF) and is associated with higher mortality, higher symptom burden, and worsened health-related quality of life. However, the genomic mechanisms underlying chronic pain in HF are understudied. Building an understanding of the mechanistic underpinnings of pain may inform novel interventions.

Objective
The objective was to identify genes associated with pain from mRNA sequence data collected from patients with HF with and without pain.

Methods
The current study analyzed data from 40 patients with HF previously enrolled in a clinical trial. Pain presence was measured using the Health Utilities Index Mark-3. Genes were tested for differential expression using DESeq2, and differentially expressed genes were analyzed for protein–protein interaction (PPI) and relevant ontological pathways using Metascape. Genes located within the core of the PPI network were considered key in disease-relevant biological pathways. Differentially expressed genes within this PPI network were reviewed in existing literature to narrow down candidate genes of interest. These target genes of interest were reanalyzed in a second sample of 24 patients with HF using validation quantitative polymerase chain reaction.

Results
A total of 334 genes (279 upregulated, 55 downregulated) were differentially expressed between patients with and without pain in the primary sample of 40. These genes were largely aligned with neutrophil degranulation pathways. Seven genes of interest were identified from a core network of 15 co-expressed genes in the PPI network and existing literature. Three of these seven genes: matrix metallopeptidase 8 (MMP8), proprotein convertase subtilisin/kexin type 9 (PCSK9), and neutrophil defensin 3 (DEFA3) were upregulated in patients with pain versus without pain in both the primary and validation samples. All seven genes of interest are involved in immune, inflammatory, and atherosclerotic processes.

Discussion
These results identify potential genes that may play a mechanistic role in chronic pain in HF. Further research is needed to evaluate these potential genes among clearly delineated pain phenotypes.
Nutritional prehabilitation strategies for patients undergoing head and neck cancer: a scoping review
Authors: Xue Fang , Zhang Mengli , Duan Huan , Zhang Jing 
Published: March 2023

Abstract

Background:
Given the high incidence of malnutrition before anti-cancer treatment in patients with head and neck cancer (HNC), it is necessary to pay attention to nutritional interventions for them before surgery, radiotherapy, and chemotherapy. Nutritional prehabilitation strategies vary considerably in their implementations.

Objective:
This scoping review aimed to summarize the nutritional prehabilitation strategies for HNC patients.

Methods:
We conducted a scoping review based on the framework outlined by the Joanna Briggs Institute (JBI) methodology (Joanna Briggs Institute, 2020). Twelve articles focused on the effects of preoperative nutritional intervention on the nutritional status of patients with HNC who underwent surgery, radiotherapy, or chemotherapy. We synthesized the screening or evaluation tool for the nutrition prerehabilitation intervention strategy, type of nutrition supplement, intervention goal, frequency, duration, re-evaluation, and supervision.

Results:
Findings suggest that preoperative nutritional intervention can improve recovery from anti-cancer treatment and patient physical reserves for coping with surgical stress. Therefore, patients with HNC who are at risk of malnutrition are recommended for early nutritional interventions.
Application of Paranasal Augmentation Rhinoplasty in Asians With Midfacial Concavity
Authors: Zhao Runlei , Pan Bailin , Li Dong , An Yang 
Published: March 2023

Background
For Asian rhinoplasty patients with midfacial concavity, the conventional method is to solve the problem by using structural rhinoplasty to increase the nasal height and length. However, the results are not satisfying, and many complications are caused.
Paranasal augmentation as an adjunct to rhinoplasty can improve surgical results and increase satisfaction. However, there are limited studies focusing on the details and evaluation of this technique.

Objectives
To investigate a minimally invasive method to correct midfacial concavity simultaneously with rhinoplasty, as well as improve satisfaction and reduce complications.

Materials and Methods
Between January 2010 and December 2019, we reviewed all rhinoplasty patient records from patients who had midfacial concavity and underwent simultaneous paranasal augmentation with our technique. The patient demographics, surgical characteristics, and outcomes were reviewed retrospectively. Satisfaction was evaluated by an independent medical staff who reviewed the preoperative and postoperative photos.

Results
Sixty-seven patients were included in the study. The mean age of the patients was 28.7 ± 8.0 years, and the median follow-up time was 26 months (range, 2–60 months). Overall satisfaction was high (90%). Eight (12%) patients had complications, including 5 (7.4%) cases of implant displacement and 3 (4.4%) cases of infection. All patients healed uneventfully after revision surgery.

Conclusions
Paranasal augmentation can improve the outcome and increase satisfaction in Asian rhinoplasty patients who have midfacial concavity. Preoperative patient evaluation, surgery planning, and surgery details are crucial to ensure a favorable result. The expanded polytetrafluoroethylene implant has advantages over other materials and therefore is recommended in paranasal augmentation surgery.
Gracilis Muscle Interposition to Fill the Perianal Dead Space May Decrease Hospital Length of Stay in Fournier's Gangrene
Authors: Ismayilzade Majid , Dadaci Mehmet , Kendir Münür Selçuk , Ince Bilsev 
Published: March 2023

Purpose
The treatment of Fournier's gangrene (FG) includes aggressive debridement of the affected necrotic area, broad-spectrum antibiotic therapy, and reconstructive procedures, respectively. One of the main reasons of unfavorable outcomes in FG surgery is that the dead space occurs in the perianal region because of destruction of fascias and soft tissues. In this study, we aimed to evaluate the results of gracilis muscle flap transposition to fill the FG-associated perianal dead spaces.

Methods
Patients treated for FG-associated dead spaces in their perianal region between the years 2017 and 2021 were included in the study. The patients who underwent the pedicled gracilis muscle flap surgery were included in group 1, whereas group 2 consisted of the patients with no additional surgical procedure for dead spaces but only the reconstruction of the soft tissue defects. Demographic data (age, sex), comorbid diseases, localization and length of perianal dead space, and management method for the soft tissue defects and complications were noted. The length of hospital stay and discharge day after surgery were also recorded.

Results
In group 1, the mean duration of hospital stay was 23.5 ± 5.0 (range, 14–48) days, whereas the mean period between the surgery and discharge was 5.1 ± 2.2 (range, 3–12) days. These numbers were 31 ± 8.3 (range, 19–58) days and 12.7 ± 6.1 (range, 7–22) days in group 2, respectively. Statistical comparison of the periods between the surgery and discharge was found to be significantly different (P = 0.022). The duration of hospital stay was also shorter in the patients with gracilis muscle flap (P = 0.039).

Conclusions
Perianal dead spaces accompanying many of the patients with FG provide appropriate conditions for bacterial colonization. Filling these pouches by the gracilis muscle flap prevented the progression of infection and enabled the patients to return to their normal life earlier.
Masson Tumor of the Heel Fat Pad
Authors: Sung Kunyong , Jeong Chanho , Lee Seungkoo , Oh Ha Yeun , Lee Sang-Yeul 
Published: March 2023

AbstractIntravascular papillary endothelial hyperplasia (Masson tumor) is an uncommon benign vascular lesion characterized by a reactive proliferation of endothelial cells. This lesion commonly occurs in the head, neck, and upper extremities. Although it can be found anywhere in the body, the lesion has never affected the heel fat pad. This report presents a rare case of Masson tumor of the heel fat pad to facilitate the recognition of this uncommon lesion and also suggests other conditions to be considered when diagnosing heel lesions.
Tapentadol for the management of cancer pain in adults: an update
Authors: Boland Jason W. 
Published: March 2023

Purpose of review
Tapentadol is the first of a new class of analgesics, having synergistic µ-opioid receptor agonist and noradrenaline reuptake inhibitory actions. It has been widely researched in many areas of pain, often in noninferiority studies against potent opioids. This review describes all randomized and recent nonrandomized studies of tapentadol in adults with cancer pain.

Recent findings
Tapentadol has been shown to be at least as effective as morphine and oxycodone in five randomized (two of which were multicenter and double-blind) and a range of nonrandomized trials, although caution is needed when interpreting these results. It is effective in both opioid-naive patients and those already taking opioids. By having a lower µ-opioid receptor binding affinity, it has fewer opioid-related toxicities such as constipation and nausea. A recent randomized trial comparing tapentadol to tapentadol plus duloxetine in patients with chemotherapy-induced peripheral neuropathy shows similar improvement in both groups in a range of pain relieving and quality of life measures, with similar adverse effects.

Summary
Tapentadol has been shown in a range of studies to be an effective analgesic and thus should be considered as an alternative to morphine and oxycodone, especially when opioid toxicities are an issue.