bluuebunny/crossref_metadata_2025_split huggingface dataset:
Decursinol angelate relieves inflammatory bowel disease by inhibiting the ROS/TXNIP/NLRP3 pathway and pyroptosis
Authors: Wang Yudi , Wang Jiamin , Chen Yonghu , Li Xuezheng , Jiang Zhe 
Published: January 2025

IntroductionDespite evidence of the efficacy of decursinol angelate (DA), a prescription medication derived farom traditional Chinese medicine, in alleviating inflammatory bowel disease (IBD), the precise mechanisms behind its action remain unclear.MethodsLipopolysaccharides (LPS) and dextran sodium sulfate (DSS) induction were used as in vitro and in vivo models of IBD, respectively, to assess the role of DA in alleviating IBD. Enzyme-linked immunosorbent assay (ELISA) was performed to detect the expression levels of pro-inflammatory cytokines in mouse serum, Western blot was performed to detect the expression of TXNIP/NLRP3 pathway tight junction (TJ) proteins in colon tissues and cells, and immunohistochemistry, immunofluorescence and immunohistochemistry, immunofluorescence and qRT-PCR were used to validate the proteins related to this signaling pathway. Molecular docking technique and co-immunoprecipitation (Co-IP) method assay were applied to evaluate the targeting effect of DA on NLRP3 proteins, and MCC950, a specific inhibitor of NLRP3, was used as a positive control for validation.ResultsOur research indicates that DA’s distinctive molecular mechanism could entail binding to the NLRP3 protein, thereby suppressing the activation of the NLRP3 pathway and diminishing the assembly and activation of the NLRP3 inflammasome, thus functioning as an anti-inflammatory agent.ConclusionDA may play a role in improving BD by inhibiting the activation of the ROS/TXNIP/NLRP3 signaling pathway and the release of inflammatory mediators, and by repairing the intestinal barrier function.
Enhancing home-based physical activity for neurodivergent children: adapting the InPACT at Home program with AI and universal design
Authors: Sapre Tania , Miller Haylie L. , Schwartz Anna , Ketcheson Leah R. , Price Alanna , Winkelseth Kerry , Barcelona Jeanne M. , Zernicke Ronald F. , Hasson Rebecca E. 
Published: January 2025

PurposeWhile it is common practice for schools across the United States to include neurodivergent children in physical education classes, many programs outside of school—such as those at home or in the community—are not effectively tailored to meet their support needs. This gap contributes to lower levels of physical activity among neurodivergent children. Our objective was to address this issue by systematically adapting the InPACT (Interrupting Prolonged sitting with ACTivity) at Home program to enable neurodivergent children to safely engage in physical activity at home.MethodsThe rapid-cycle research adaptation process involved several key steps: (1) sorting and grouping video content based on different types of skills and exercises (problem exploration); (2) assembling an expert team to guide the development of the instructions (knowledge exploration); and (3) using generative artificial intelligence (AI) to create concise instructions and cue words for each skill/exercise (solution development). These outputs were then fine-tuned by the expert team. The refinements were guided by the Universal Design for Learning (UDL) principle of “Representation,” which acknowledges that learners perceive and understand information in diverse ways.ResultsFrom the 132 InPACT at Home videos, over 500 activities were identified and categorized into main skill groups: jumping, core, lateral, sport, upper body, lower body, and compound movements. Expert meetings emphasized the importance of the “Three C’s”—consistency, conciseness, and clarity—in crafting instructions, along with the use of simple, elementary sight words. AI was employed to generate and refine prompts like “Provide simplified step-by-step instructions for a jumping jack, suitable for a neurodivergent child” and “Condense the step-by-step instructions for a jumping jack, suitable for a neurodivergent child”.DiscussionThe adaptation of the existing InPACT at Home program was guided by dissemination and implementation science frameworks, aiming to increase equitable access to structured youth physical activity opportunities for neurodivergent children. By incorporating AI and UDL principles, we aim to further enhance the program’s accessibility. Our next steps include evaluating the effectiveness of our program adaptations in encouraging participation in the InPACT at Home program and subsequently increasing physical activity levels among neurodivergent children.
Six weeks that changed the preterm infant brain: lessons learned from the Family Nurture Intervention randomized controlled trials
Authors: Ludwig Robert J. , Myers Michael M. , Welch Martha G. 
Published: January 2025

AimWe review extensive results from two randomized controlled trials conducted over 9 years, comparing standard care (SC) in level-4 neonatal intensive care units (NICUs) with SC plus Family Nurture Intervention (FNI).MethodsFNI included ~six weeks of facilitated mother-infant interactions aimed at achieving mother-infant ‘autonomic emotional connection’, a novel construct that describes the emotional mother-baby relationship at the level of the autonomic nervous system.Results and conclusionThus far, 18 peer-reviewed publications documented significant positive short-and long-term effects of FNI on infant neurobehavioral functioning, developmental trajectories and both mother and child autonomic health through five years. The observed profound effects of FNI on central and autonomic nervous system function following a relatively short intervention support a novel autonomic theory of emotions. We discuss the theoretical and clinical advances that grew out of the trials and speculate on how FNI changes the mother-infant relationship from ‘dysregulation’ to autonomic emotional co-regulation. We review new constructs and tools that can be used to view and measure the mother-infant autonomic emotional relationship. We present a simple blueprint to improve preterm birth outcomes. Finally, we discuss the significance of our findings and possible impact on the future of preterm infant care worldwide.
The influence of emotional intelligence on learning burnout in Chinese art college students: the chain mediation effect of self-acceptance and perceived stress
Authors: Zhang Meng , Fah Lay Yoon 
Published: January 2025

IntroductionArt college students are under special pressure from a few sources, including study, employment, friends, emotions, family relations and other aspects. This can lead to a reasonable degree of learning burnout among art college students, which will have a negative impact on their physical and mental health, as well as their study and employment. However, there is a paucity of empirical studies on learning burnout among art students. Furthermore, the factors and mechanisms that contribute to learning burnout among art students remain unclear. The purpose of this study was to examine the relationship between emotional intelligence and learning burnout in Chinese art college students, and to identify the role of self-acceptance and perceived stress as sequential mediators.MethodsThis study employed a completely random survey of three art universities in China to investigate the status of emotional intelligence, self-acceptance, perceived stress and learning burnout among art students and their relationships. The data was analyzed using an independent sample t-test and structural equation modelling.ResultsA total of 678 valid samples were obtained from a study of Chinese art students. No significant differences were observed in the scores of emotional intelligences, self-acceptance, perceived stress, and learning burnout among participants of different genders. The results of the structural equation modelling indicated that emotional intelligence was negatively associated with learning burnout (β = −0.282, p &lt; 0.001). The results indicated that self-acceptance (β = −0.140, p &lt; 0.001) and perceived stress (β = −0.072, p &lt; 0.001) had independent mediating effects. Furthermore, self-acceptance and perceived stress exhibited sequence mediating effects (β = −0.039, p &lt; 0.001).ConclusionThe results of the study confirm that emotional intelligence is a significant factor in the learning burnout of art students. Furthermore, the findings demonstrate the mediating effect of self-acceptance and perceived pressure on this relationship. The findings provide a novel explanation for the mechanism underlying college students’ learning burnout.
Longitudinal reciprocal relationship between media violence exposure and aggression among junior high school students in China: a cross-lagged analysis
Authors: Dou Yifei , Zhang Meng 
Published: January 2025

IntroductionIncreasing evidence has shown that media violence exposure can influence individual aggression. However, the question of whether there is a causal relationship between media violence exposure and aggression remains complex and contentious. This study aims to examine the dynamic reciprocal relations between media violence exposure and aggression among junior high school students in China.MethodsUsing the Exposure to Violent Media Questionnaire (ETVMQ) and the Buss-Warren Aggression questionnaire (BWAQ), 259 junior high school students were tracked three times over a period of 1 year. A cross-lagged panel model was constructed to analyze the reciprocal relationship between media violence exposure and aggression over time.Results(1) Media violence exposure and aggression were significantly and positively correlated in all three assessments. (2) Cross-lagged analysis revealed that media violence exposure at Time 1(T1) significantly positively predicted aggression at Time 2(T2), and subsequently significantly positively predicted media violence exposure at Time 3(T3). Additionally, media violence exposure at T2 significantly positively predicted aggression at T3. (3) Multi-group analysis revealed that gender, family economic status, and family location had no significant moderating effects on the cross-lagged effects between media violence exposure and aggression. The cross-lagged effects did not differ by gender, family economic status, or family location.ConclusionThere is a positive reciprocal relationship between media violence exposure and aggression among Chinese junior high school students, and this reciprocal relationship demonstrates stability across gender and family environments. Media violence exposure is not only a risk factor for increasing aggression among Chinese junior high school students but also a negative outcome of high aggression.
The relationship between social support and work engagement of rural teachers: a moderated mediation model
Authors: Wu Shengwen , Xu Qiangqiang , Tian Huidong , Li Rongrong , Wu Xiaopeng 
Published: January 2025

AimThis paper aims to investigate the relationship between social support and rural teachers’ work engagement while exploring the mediating effect of mindfulness in teaching and the moderating effect of psychological safety.MethodsA sample of 866 rural teachers was recruited, in order to complete the Mindfulness in Teaching Scale, Social Support Rating Scale, Psychological Safety Scale, and Utrecht Work Engagement Scale.ResultsThe study findings indicate that: (1) social support positively influenced the work engagement of rural teachers; (2) further, mindfulness in teaching partially mediated the effect of social support on rural teachers’ work engagement; (3) psychological safety moderated the second half of the pathway of “social support → mindfulness in teaching → work engagement” while the positive correlation between mindfulness in teaching and work engagement was stronger among rural teachers with high psychological safety.ConclusionSocial support documented a strong correlation with work engagement while mindfulness in teaching mediated the pathway between the aforementioned variables. Furthermore, psychological safety moderated the second half of the mediated pathway (the link from mindfulness in teaching to work engagement). Hence, the study outcomes reveal the influential mechanism of social support on the work engagement of rural teachers. This finding suggests that we need to further improve the social support system and its effect mechanism in order to improve the rural teachers’ work engagement. At the same time, it is also very important to create a good psychological working environment to ensure that they maintain a good level of mindfulness in teaching.
Poor self-reported sleep is associated with prolonged white matter T2 relaxation in psychotic disorders
Authors: Yesilkaya Umit Haluk , Chen Xi , Watford Lauren , McCoy Emma , Sen Meltem , Genc Ilgin , Du Fei , Ongur Dost , Yuksel Cagri 
Published: January 2025

BackgroundPsychotic disorders are characterized by white matter (WM) abnormalities; however, their relationship with the various aspects of illness presentation remains unclear. Sleep disturbances are common in psychosis, and emerging evidence suggests that sleep plays a critical role in WM physiology. Therefore, it is plausible that sleep disturbances are associated with impaired WM integrity in these disorders. To test this hypothesis, we examined the association of self-reported sleep disturbances with WM transverse (T2) relaxation times in a cross-diagnostic sample of patients with psychosis.MethodsA total of 28 patients with psychosis (11 schizophrenia spectrum disorders and 17 bipolar disorder with psychotic features) were included. Metabolite (N-acetyl aspartate, choline, and creatine) and water T2 relaxation times were measured in the anterior corona radiata at 4T. Sleep was evaluated using the Pittsburgh Sleep Quality Index (PSQI).ResultsPSQI total score showed a moderate to strong positive correlation with water T2 (r = 0.64, p&lt; 0.001). Linear regressions showed that this association was independent of the overall severity of depressive, manic, or psychotic symptoms. In our exploratory analysis, sleep disturbance was correlated with free water percentage, suggesting that increased extracellular water may be a mechanism underlying the association of disturbed sleep and prolonged water T2 relaxation.ConclusionOur results highlight the connection between poor sleep and WM abnormalities in psychotic disorders. Future research using objective sleep measures and neuroimaging techniques suitable to probe free water is needed to further our insight into this relationship.
Prevalence, consequences, and contributing factors beyond verbal and physical workplace violence against nurses in peripheral hospitals
Authors: Alnaeem Mohammad M. , Hasan Suleiman Khaled , Alzoubi Majdi M. , Sumaqa Yasmeen Abu , Al-Mugheed Khalid , Saeed Alabdullah Amany Anwar , Farghaly Abdelaliem Sally Mohammed 
Published: January 2025

BackgroundGlobally, nearly one-third of workplace violence (WPV) occurs in the health sector. Exposure to WPV among Jordanian nurses has been widely speculated to be underreported. Understanding of the factors contributing to WPV among nurses and their consequences is limited.ObjectivesThis study aimed to examine the consequences and contributing factors of WPV and explore suggestions for reducing WPV among nurses working in peripheral hospitals.MethodsThis descriptive, cross-sectional study included 431 Jordanian nurses. Data were collected using a self-report instrument between December 2022 and June 2023. A modified version of the ILO/ICN/WHO/PSI Workplace Violence in the Health Sector Country Case Study Questionnaire developed and validated in 2003 was used.ResultsThe ages of the participants ranged from 20 to 49 years. A total of 349 nurses (81%) had experienced verbal violence, while 110 (25.5%) had experienced physical violence. Of the 110 nurses who were physically attacked, 44 (40 %) reported that an investigation was conducted to determine the cause of the incident. Approximately 38.2% of incidents involving physical violence in the last 12 months involved the use of weapons. The current study revealed that 59.6% of the nurses reported that verbal incidents were common in their workplace. The highest level of agreement among all participants was leniency in applying penalties to perpetrators of violence inside hospitals. The majority of participants (95.8%) agreed that improving staff-patient communication skills would effectively reduce violence.ConclusionCreating awareness among healthcare professionals, patients, and the general public regarding the impact of WPV and the importance of respect and professionalism is crucial.
Burnout and its relationship with depressive symptoms in primary school teachers under the “Double Reduction” policy in China
Authors: Zhong Yunhui , Lai Shuixiu , Li Yibo , Yang Kan , Tang Hong , Zhang Xiang-yang 
Published: January 2025

BackgroundThe “Double Reduction” policy requires schools to reduce Chinese students’ extracurricular activities and homework to lessen academic stress and improve mental well-being. However, there is limited research on primary school teachers’ psychological well-being within the context of the “Double Reduction” policy. This study examined self-reported burnout levels of primary school teachers and investigated the relationship between burnout and depressive symptoms in the context of the “Double Reduction” policy in China.MethodsA cross-sectional survey recruited 3,199 primary school teachers from 15 cities across China. The teachers’ burnout levels were assessed with the Maslach Burnout Inventory, and depressive symptoms were evaluated with the Patient Health Questionnaire depression scale.ResultsUnder the “Double Reduction” policy in China, 66.6% of the primary school teachers experience burnout. Individual and work-related characteristics were independently correlated with burnout. These factors included holding a bachelor’s degree (OR = 2.244, 95% CI: 1.559–3.230, p &lt; 0.001), being married (OR = 0.598, 95% CI: 0.443–0.807, p &lt; 0.001), being dissatisfied with one’s income (OR = 2.602, 95% CI: 2.191–3.090, p &lt; 0.001), and having an intermediate professional title (OR = 1.351, 95% CI: 1.086–1.681, p = 0.007). The correlation coefficients between burnout subscale scores and depressive symptoms were 0.588 for emotional exhaustion, 0.585 for cynicism, and − 0.180 for professional efficacy (all p &lt; 0.001).ConclusionOur findings indicate that the prevalence of burnout among primary school teachers in China is exceptionally high, particularly under the “Double Reduction” policy. This situation is correlated with various psychological disorders, including depression. It is crucial to urgently implement psychological interventions for primary school teachers. Specifically, psychological assistance should be targeted at educators who are bachelor degree holders, married, dissatisfied with their income, and holders of an intermediate professional title.
Design of the Focus on Restaurant Engagement to Strengthen Health (FRESH) study: leveraging systems science to work with independently-owned restaurants to increase access to and promotion of healthful foods
Authors: Colón-Ramos Uriyoán , Lewis Emma C. , Tucker Anna Claire , Poirier Lisa , Pathiravasan Chathurangi H. , Estradé Michelle , Igusa Takeru , Wolfson Julia A. , Mui Yeeli , Vélez-Burgess Veronica , Thomas Audrey E. , Hua Shuxian , Cheskin Lawrence J. , Trujillo Antonio J. , Oladimeji Ayoyemi T. , Williamson Stacey , Romero Rosalinda , Hernández Patricia Sánchez , Gittelsohn Joel 
Published: January 2025

BackgroundHigh dietary quality can protect against diet-related chronic diseases. In the United States, racial and ethnic minorities and those with lower incomes consistently exhibit lower dietary quality. Independently-owned restaurants are a common prepared food source in minority low-income communities, but there are significant knowledge gaps on how to work with these restaurants to offer healthy food, due to underlying and dynamic complexities associated with providing healthy food options.MethodsThe Focus on Restaurant Engagement to Strengthen Health (FRESH) study addresses this complex problem by leveraging systems science approaches to work with independently-owned restaurants. FRESH has two interrelated objectives: (1) to test impact on regular customer dietary quality via a multisite cluster randomized controlled trial in two low-income urban areas (Baltimore and the Washington DC metropolitan area), and (2) to use systems science approaches to develop, parameterize, and calibrate a simulation model. The intervention is theory-and practice-based, comprising three phases: restaurant engagement, low-sugar beverages and healthy meals. The FRESH intervention will be implemented for 12 months in a total of 24 intervention and 24 comparison restaurants. The study is powered to detect a 5-point change in the Healthy Eating Index (HEI) score of regular customers, which would signify a meaningful shift toward healthier eating patterns.DiscussionThe FRESH study will test a novel, multilevel, multisite intervention that aims to improve access to healthier prepared food options among small, independently-owned restaurants located in under-resourced settings. The design of the FRESH intervention and its evaluation are described, as well as plans for the development of a system dynamics simulation model for policymakers and other stakeholders to virtually test future restaurant-based interventions.Clinical trial registrationhttps://clinicaltrials.gov, identifier, NCT05869149.