bluuebunny/crossref_metadata_2025_split huggingface dataset:
miEAA 2023: updates, new functional microRNA sets and improved enrichment visualizations
Authors: Aparicio-Puerta Ernesto , Hirsch Pascal , Schmartz Georges P , Kern Fabian , Fehlmann Tobias , Keller Andreas 
Published: May 2023

Abstract
MicroRNAs (miRNAs) are small non-coding RNAs that play a critical role in regulating diverse biological processes. Extracting functional insights from a list of miRNAs is challenging, as each miRNA can potentially interact with hundreds of genes. To address this challenge, we developed miEAA, a flexible and comprehensive miRNA enrichment analysis tool based on direct and indirect miRNA annotation. The latest release of miEAA includes a data warehouse of 19 miRNA repositories, covering 10 different organisms and 139 399 functional categories. We have added information on the cellular context of miRNAs, isomiRs, and high-confidence miRNAs to improve the accuracy of the results. We have also improved the representation of aggregated results, including interactive Upset plots to aid users in understanding the interaction among enriched terms or categories. Finally, we demonstrate the functionality of miEAA in the context of ageing and highlight the importance of carefully considering the miRNA input list. MiEAA is free to use and publicly available at https://www.ccb.uni-saarland.de/mieaa/.
Histone chaperone Nap1 dismantles an H2A/H2B dimer from a partially unwrapped nucleosome
Authors: Nagae Fritz , Takada Shoji , Terakawa Tsuyoshi 
Published: May 2023

Abstract
DNA translocases, such as RNA polymerases, inevitably collide with nucleosomes on eukaryotic chromatin. Upon these collisions, histone chaperones are suggested to facilitate nucleosome disassembly and re-assembly. In this study, by performing in vitro transcription assays and molecular simulations, we found that partial unwrapping of a nucleosome by an RNA polymerase dramatically facilitates an H2A/H2B dimer dismantling from the nucleosome by Nucleosome Assembly Protein 1 (Nap1). Furthermore, the results uncovered molecular mechanisms of Nap1 functions in which the highly acidic C-terminal flexible tails of Nap1 contribute to the H2A/H2B binding by associating with the binding interface buried and not accessible to Nap1 globular domains, supporting the penetrating fuzzy binding mechanism seemingly shared across various histone chaperones. These findings have broad implications for the mechanisms by which histone chaperones process nucleosomes upon collisions with translocases in transcription, histone recycling and nucleosomal DNA repair.
MBROLE3: improved functional enrichment of chemical compounds for metabolomics data analysis
Authors: Lopez-Ibañez Javier , Pazos Florencio , Chagoyen Monica 
Published: May 2023

Abstract
MBROLE (Metabolites Biological Role) facilitates the biological interpretation of metabolomics experiments. It performs enrichment analysis of a set of chemical compounds through statistical analysis of annotations from several databases. The original MBROLE server was released in 2011 and, since then, different groups worldwide have used it to analyze metabolomics experiments from a variety of organisms. Here we present the latest version of the system, MBROLE3, accessible at http://csbg.cnb.csic.es/mbrole3. This new version contains updated annotations from previously included databases as well as a wide variety of new functional annotations, such as additional pathway databases and Gene Ontology terms. Of special relevance is the inclusion of a new category of annotations, ‘indirect annotations’, extracted from the scientific literature and from curated chemical-protein associations. The latter allows to analyze enriched annotations of the proteins known to interact with the set of chemical compounds of interest. Results are provided in the form of interactive tables, formatted data to download, and graphical plots.
Early-life undernutrition and depression later in life: a systematic review
Authors: de Souza Julliet Araújo , Pinto Flaydson Clayton Silva , de Souza Sandra Lopes 
Published: May 2023

Abstract

Context
Early adverse experience can have a long-term effect on growth and development and negative repercussions into adulthood. Among the various consequences of undernutrition is depression.

Objective
The present work aimed to evaluate the relationship between early-life undernutrition and depression in adult life.

Data Sources
Data were obtained from the PubMed, SCOPUS, and Web of Science databases in November 2021 and were selected using the systematic bibliographic review manager program State of the Art Through Systematic Review.

Data Extraction
Data were extracted using the State of the Art Through Systematic Review program.

Data Analysis
Of the 559 articles that were identified, 114 were duplicates, and 426 were excluded after inclusion and exclusion criteria were applied to the title and abstract. One other relevant study was included. From the 20 remaining articles, 8 were excluded after the full-text screening. Finally, 12 articles remained for review in the present work. The studies described in these articles investigated humans, rats, or mice, and correlated early-life malnutrition and depression in adulthood as the principal outcome.

Conclusions
Undernutrition in early life and later depression are linked. Furthermore, the knowledge that the risk factors for depression start at the beginning of life points to public health policies starting in intrauterine life and extending throughout childhood and adolescence.
Baltimore Beginnings
Authors: Crease Stephanie Stein 
Published: May 2023

Abstract
William Henry “Chick” Webb was born in 1905 in East Baltimore, a working-class neighborhood. He was the second of four children of William Henry Webb Sr. and Marie Florence Johnson, and their only son. Incorrect data and lack of documentation compound the challenges of researching his and other Black family histories of the time, leaving discrepancies about birth dates and other vital statistics. Webb’s father left the family when Chick was seven years old and died when Chick was thirteen. Chick was raised by his mother and close-knit extended family; his step-grandfather, Clarence Jones, became the steady male presence in his life. When Webb was three or four, he was afflicted with spinal tuberculosis, impacting his growth and leading to his spinal deformity. He was treated by pioneering Black physician Dr. Ralph J. Young. As a child Webb sold newspapers in downtown Baltimore and earned enough to purchase a used drum set. As a young teen, he played for parties and dances, and Clarence Jones helped him carry his drums to events and dance halls.
Scuffling in Heaven
Authors: Crease Stephanie Stein 
Published: May 2023

Abstract
Thanks largely to Eubie Blake and his and Noble Sissle’s 1921 Broadway hit musical Shuffle Along, Baltimore musicians had a good reputation in New York. Chick Webb and his best friend, guitarist Johnny Trueheart, moved there in 1925 and settled in Harlem in the midst of the Harlem Renaissance. They discovered the Rhythm Club in central Harlem, an unofficial union for Black musicians. In nightly jam sessions there and at clubs nearby, they heard the best Black musicians on the New York scene and got exposure in this competitive environment. Webb met Duke Ellington, then leading his Washingtonians at the Kentucky Club in midtown, and started learning the New York “pecking order” to get jobs: jam sessions, rent parties, dancing schools, and nightclubs. The Prohibition era (banning alcohol) led to a network of gangster-owned speakeasies in midtown and in Harlem, attracting white tourists to cabarets like the Cotton Club, Connie’s Inn, and Small’s Paradise, featuring elaborate floor shows and revues with the best Black bands, dancers, and entertainers.
The Reasoning of Constitutional Courts in Europe
Authors: Jakab András 
Published: May 2023

Abstract
This chapter gives an overview of the different types of constitutional reasoning in Europe. Courts interpreting constitutions must deal with the issue of extracting the greatest amount of meaning from a relatively short text. In doing so, courts have developed a set of techniques of interpretation that guides them to a system of concepts (Verfassungsdogmatik), which is more sophisticated than the actual text of their constitutions. The chapter analyses the case-law of national constitutional courts in the European legal space and that of the ECJ and ECtHR. It shows that no specific form of European constitutional reasoning exists. On the contrary, the main trends and characteristics that can be observed in Europe can also be seen worldwide, and the reasoning styles are as diverse in Europe as they are worldwide.
ECJ and ECtHR: Two Senates of Europe’s Constitutional Jurisdiction
Authors: von Bogdandy Armin , Krenn Christoph 
Published: May 2023

Abstract
The goal of this contribution is to develop a concept for Europe’s constitutional jurisdiction, which is essentially exercised by two courts: the European Court of Justice and the European Court of Human Rights. We argue that the two courts can be best described as the ‘two senates’ of Europe’s constitutional jurisdiction. The image of ‘two senates’ expresses the idea that the two courts bear a shared responsibility for the European legal space to which they each contribute in specific ways. The European Court of Justice’s role, as ‘first senate’, is best understood through its contribution to European political unity by fostering and controlling European public authority and ensuring its uniform effect in the European legal space. The European Court of Human Rights, which we consider Europe’s ‘second senate’, aims to entrench a set of basic norms—European human rights—in the European legal space. The contribution employs the concept of ‘two senates’ to trace the genesis of Europe’s constitutional jurisdiction, to conceptualize the differences between the courts’ constitutional work, and to analyse their relationship.
Movements of the Mind
Authors: Wu Wayne 
Published: May 2023

Abstract
Movements of the Mind explains what it is to be an agent. Focusing on mental agency, the book’s eponymous topic, it investigates an agent’s doing things by integrating multiple approaches, from philosophical analysis of how we conceptualize agency to the recording of the activity of single cells in the brain. Philosophical and empirical work are integrated in an accessible way that generates concrete explanations of key aspects of mind including the central role played by attention and intention. The theory is applied to illuminate automaticity in biased behavior, the dynamics of deductive reasoning, and the psychology of introspecting perceptual consciousness. Topics covered include attention, intention, working memory, learning, skill, automaticity, control, bias, reasoning, introspection, self-awareness, and consciousness.
Vulnerability and Data Protection Law
Authors: Malgieri Gianclaudio 
Published: May 2023

Abstract
Vulnerability is the hallmark of human beings in the twenty-first century. In the digital environment, this is particularly evident. Vulnerabilities are generally considered using a group-based approach: ethnic minorities, children, the elderly, people with disabilities, etc. However, this static approach might prove to be inaccurate: the digital media have reshaped groups and individuals by inducing new vulnerabilities and creating different vulnerable sub-groups of users, consumers, citizens, and data subjects. This book is conceived not only to show problems but to offer a perspective of critical optimism towards viable solutions. The EU General Data Protection Regulation is not just the legal instrument used to analyse criticalities in the existing digital world but it is also primarily a forward-looking set of tools that, though largely underexplored, might prove to be essential in rebalancing power asymmetries and mitigating induced vulnerabilities in the age of AI. While many authors have focused on the nuances of data controllers and data processors, few scholars have focused on the characteristics of the data subjects. Accordingly, this book has three related goals: (i) investigating the notion of the data subject and understanding whether and how personal conditions influence the definition and the protection this subject; (ii) reconceptualizing the notion of vulnerability in the data protection framework, proposing a layered, contextual, and relational notion; (iii) promoting a vulnerability-aware interpretation of the GDPR. The aim of this book is to start promoting the data subjects’ layered vulnerability as a heuristic tool in order to re-interpret the GDPR and to reconceptualize the risk-based approach on an individual-centred basis.
Antígonas
Authors: Fradinger Moira 
Published: May 2023

Abstract
The first book in the English language to approach classical reception through the study of one classical fragment as it circulates throughout Latin America, this interdisciplinary research engages comparative literature, Latin American studies, classical reception, history, feminist theory, political philosophy, and theater history. It tracks the ways in which, since the early nineteenth century, fragments of Antigone’s myth and tragedy have been persistently cannibalized and ruminated throughout South and Central America and the Caribbean, quilted to local dramatic forms, revealing an archive of political thought about Latin America’s heterogeneous neocolonial histories. The book constructs a corpus of over seventy vernacular Antígona plays and studies its intra-American variations and patterns across time, finding a continental set of interrelated discourses about politics, womanhood, motherhood, sisterhood, and, to a certain extent, burials. Antígona is consistently characterized as a national mother and, as the twentieth century advances, multiplied on stage, forming female collectives, foregrounding the urgency of systemic change or staging gender politics. As it examines classical culture in neocolonial contexts, the book explores ways of reading Creole texts from the geopolitical South that disrupt the colonial reading protocols that deracinate texts or lock them into locality. By historicizing Antígona plays and interpreting them with homegrown terminology that addresses specific colonial legacies, the book reveals how Antígona has ceased being Greek and instead tells stories of twentieth- and twenty-first-century Latin America. Antígonas rethinks the paradigms through which we understand the presence of ancient cultural materials in former colonial territories, while illuminating an understudied continent in Anglophone reception studies.
The Incorruptible
Authors: Fradinger Moira 
Published: May 2023

Abstract
Chapter 6 examines Griselda Gambaro’s 1986 Antígona Furiosa, written in honor of the Argentine Mothers of Plaza de Mayo, a political movement of mothers who defied dictatorship by taking to the streets to search for their missing, searching for them to this day, more than forty years later. Gambaro’s Antígona has gathered robust international critical attention. Nonetheless, it is also one of the plays most deracinated from its context by critics, seen as referring to an abstract notion of dictatorship or through the lens of ethical lessons of ancient and modern European philosophers. This chapter engages the Argentine historical specificity embedded in the play, missed by international criticism, arguing that the play refers not to dictatorship alone but most importantly to a precise historical problem surrounding the 1985 civilian trial of the military and the 1986 split within the movement of the Mothers of the Plaza, as the Mothers saw liberal democratic notions of justice as inadequate in the case of the nation’s civilian trial of the military for crimes against humanity. The chapter argues that Antígona is a figure both for the Mothers and for the disappeared, radicalizing utopian politics by positing a demand impossible to meet without systemic social change.
Introduction
Authors: Dagher Munqith , Kaltenthaler Karl , Gelfand Michele J. , Kruglanski Arie W. , McCulloh Ian 
Published: May 2023

Abstract
The introduction sets up the research questions that the book explores: What factors conditioned public support and opposition toward ISIS in Iraq? Why did some Iraqi move from passive support for the group and actively participate in the group’s activities, including fighting? The chapter also introduces the argument of the book, namely that ISIS’s rise and fall in Iraq were largely due to the group’s impact on the human needs of Iraqis in the areas where it operated. The group was successful when it was viewed as meeting security, sustenance, and significance needs. It declined when it could no longer provide for those needs.
Joining ISIS
Authors: Dagher Munqith , Kaltenthaler Karl , Gelfand Michele J. , Kruglanski Arie W. , McCulloh Ian 
Published: May 2023

Abstract
By leveraging data collected in the years between 2012 and 2018, this chapter seeks to explain why Iraqis came to join and otherwise participate in ISIS. The data used in this chapter come from interviews with captured ISIS foot soldiers and leaders, as well as dozens of focus group interviews with Iraqis who lived in ISIS-occupied areas of Iraq and witnessed firsthand how Iraqis they knew, some from their own families, were drawn into ISIS. The data will show that there was no single path into ISIS for the Iraqis who participated in the organization. The data show that ISIS was a means for Iraqis who joined it to meet needs they faced at the time, be it for security, sustenance, or significance. What is clear is that most Iraqis did not join ISIS out of religious zealotry.
Dying by the Sword
Authors: Toft Monica Duffy , Kushi Sidita 
Published: May 2023

Abstract
Through a historical and data-driven review of the United States’ dominant foreign policy trends from 1776 until today, Dying by the Sword argues that since the end of the Cold War and especially post-9/11, the United States has initiated higher rates of military interventions, drastically escalating its usage of force abroad. Lacking clear national strategic goals, the United States now pursues a security whack-a-mole policy, more reactionary than deliberate. Dying by the Sword dedicates a chapter to each defining era of US foreign policy, applying selected historical narratives, anecdotes of US foreign policy officials, case study examples, and compelling patterns derived from the data in the Military Intervention Project (MIP). Each chapter highlights the ways in which the United States used and balanced primary tools of statecraft—War, Trade, and Diplomacy—to achieve its objectives. It showcases, however, that in recent decades, the United States has heavily favored force over the other pillars of statecraft. The book concludes with a warning that if the United States does not stem increasing trends of kinetic diplomacy, it may do irrevocable damage its diplomatic corps, dooming it to costly and often useless wars of choice. It may be doomed to the path of reactionary aggression, increasing its military footprint internationally to the detriment of its diplomatic and economic influence. If this trend continues, it could spell disaster for the United States’ image, credibility, and ultimately, its international and domestic stability.
America the Hesitant Helper
Authors: Toft Monica Duffy , Kushi Sidita 
Published: May 2023

Abstract
This chapter highlights stark reversals in US foreign policy in the pre–World War II era, moving from its previously imperialist ambitions to isolationist tendencies, and then finally to a hesitant helper of its European allies. American political and economic isolationism fanned the flames of rising fascist movements around the world, which ultimately dragged the reluctant United States from its political hibernation. This era concludes with the United States extending its tools of war, trade, and diplomacy far beyond its neighborhood to come to the rescue of Europe to end another world conflagration. Across the Western world, this era propelled the isolationist United States from that of an emergency ally to that of an often-benign great power, ready to act on the world stage. Key historical events include interventions in Central America, interventions in the Far East, the impact of the global economic crisis, isolationism, the rise of fascism, as well as World War II.
America the Unipolar Hegemon
Authors: Toft Monica Duffy , Kushi Sidita 
Published: May 2023

Abstract
As the victor of the Cold War, the United States had emerged as the liberal world hegemon, the unipolar power in the 1990s. With the fall of the Soviet Union, however, the United States lost its sense of purpose, driven by the clear rivalry and acute security challenges that its Cold War grand strategy rested upon. The post–Cold War era required a reorientation of US grand strategy and the identification of new, less threatening national interests to pursue, which proved difficult. From 1990 to 2000, the United States held to self-proclaimed good intentions (albeit selectively applied and often disastrous) of democratization, human rights promotion, and free-market expansion, evident in its foreign policies of humanitarian military interventions, regime change, multilateral missions, and free trade deals. Despite its increasing influence and power, the United States continued to rely on diplomacy and trade as pillars of its foreign policy, on top of its multilateral militarism.
Advanced Seesaw
Authors: de Alcantara Pedro 
Published: May 2023

Abstract
“Advanced Seesaw” further develops the relationship between finger action and rhythmic stimulus. It opens with a comfortable two-hand chord played over a bouncy rhythm that allows for an easy up-and-down motion of hands working together. Then it introduces a left-hand pattern with a new rhythmic structure. Over the left-hand pattern, which is repeated like a drone, the right hand plays a variety of melodies, some tonal, others modal. The sequence of compositions culminates in an extended piece that travels along the entire circle of fifths, in which every second melody calls for hand crossing. There follows a right-hand pattern that requires some stretch between fingers and that employs a new rhythmic structure, then an adaptation of this same pattern to the left hand. The chapter closes with a trio of ever more demanding pieces where the primary seesaw pattern is assigned to the left hand.
Psychic Relief and Nonnarrative Configurations in Graphic Memoirs About Mental Health
Authors: Gammelgaard Lasse R. 
Published: May 2023

Abstract
In this chapter, the concept of nonnarrative configurations is introduced to account for abstract, nonnarrative and poetic devices that are frequently employed in graphic memoirs about mental illness. Narrative medicine and health humanities approaches to graphic medicine, and in this case to graphic memoirs about mental illness, often hypothesize that composing graphic memoirs afford measures of psychic relief, and, furthermore, that this catharsis lies in the action of turning the experience of illness into a coherent narrative. That position is not refuted, but the author claims that the focus on catharsis rooted in the act of narration has overshadowed the fact that multiple nonnarrative configurations are employed for the same purpose. These configurations can either dominate (hence, the work presents itself as comics poetry), or they can be employed to produce meaning within the narrative. Nonnarrative configurations are then explored in interpretations of graphic memoirs by Art Spiegelman, Terian Koscik, and Ellen Forney.