bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hubungan Pengetahuan dan Sikap Ibu dengan Kejadian Ikterus pada Bayi Baru Lahir di Klinik Bidan Sri Widia Astuti Kecamatan Batang Kuis Kabupaten Deli Serdang
Authors: Dewi Enita Sumilvia , Siregar Siti Arofah , Karlina Fransiska Lilis , Rambe Hotmaida , Hasliana Hasliana 
Published: May 2023

ABSTRACT Neonatal jaundice is a clinical condition in infants characterized by jaundice (yellow) staining of the skin and sclera due to excessive accumulation of unconjugated bilirubin. One of the factors that influence the incidence of jaundice is knowledge and attitude. The purpose of this study was to determine the relationship between knowledge and mother's attitude with the incidence of jaundice in newborns at the Sri Widia Astuti Midwife Clinic, Batang Kuis District, Deli Serdang Regency in 2022. The type of research used was quantitative research conducted through (analysis) on mothers who had babies. want to do it directly or indirectly without any treatment or intervention with a cross sectional approach model. The test results obtained p value = 0.000 (p <0.05), so Ho is accepted. The conclusion based on statistical analysis proves that there is a relationship between maternal knowledge and attitudes with the incidence of jaundice in newborns at the Sri Widia Astuti Midwife Clinic, Batang Kuis District, Deli Serdang Regency in 2022. The results of this study are expected to be of benefit to respondents to develop their knowledge about newborns, especially if there are those who experience jaundice to be taken to the hospital for therapy. Keywords: Knowledge, Attitude, Jaundice ABSTRAK Ikterus neonatorum adalah kondisi klinis pada bayi yang ditandai dengan ikterus (kuning) pada kulit dan sklera akibat akumulasi bilirubin tak terkonjugasi yang berlebihan. Salah satu faktor yang mempengaruhi kejadian penyakit kuning adalah pengetahuan dan sikap. Tujuan penelitian ini adalah untuk mengetahui hubungan pengetahuan dan sikap ibu dengan kejadian penyakit kuning pada bayi baru lahir di Poliklinik Bidan Sri Widia Astuti Kecamatan Batang Kuis Kabupaten Deli Serdang tahun 2022. Jenis penelitian yang digunakan adalah penelitian kuantitatif yang dilakukan melalui (analisis) pada ibu yang memiliki bayi. mau melakukannya secara langsung maupun tidak langsung tanpa perlakuan atau intervensi apapun dengan model pendekatan cross sectional. Hasil pengujian didapatkan nilai p = 0,000 (p<0,05), sehingga Ho diterima. Kesimpulan berdasarkan analisis statistik membuktikan bahwa ada hubungan antara pengetahuan dan sikap ibu dengan kejadian penyakit kuning pada bayi baru lahir di Klinik Bidan Sri Widia Astuti Kecamatan Batang Kuis Kabupaten Deli Serdang Tahun 2022. Hasil penelitian ini diharapkan dapat bermanfaat bagi responden untuk mengembangkan pengetahuannya tentang bayi baru lahir, terutama jika ada yang mengalami penyakit kuning untuk dibawa ke rumah sakit untuk terapi. Kata Kunci: Pengetahuan, Sikap, Penyakit Kuning
PENIPUAN DALAM JUAL BELI KAVLING TANAH YANG DILAKUKAN PENGEMBANG PERUMAHAN KEPADA KONSUMEN
Authors: Rahmad Noor , Setiyawan Deni 
Published: May 2023

Abstrak: Tujuan utama penelitian ini adalah untuk mengetahui Dasar serta unsur-unsur hukum bagi pengembang perumahan yang melakukan penipuan jual beli tanah kavling dan Bagaimana pertanggung jawaban terhadap pengembang perumahan yang melakukan penipuan jual beli tanah kavling. Penelitian ini menggunakan jenis penelitian yuridis normatif dengan metode pendekatan Perundang- Undangan (statue approach) serta pendekatan kasus (case approach). bahan yang digunakan dalam penelitian ini berasal dari bahan hukum primer, bahan hukum sekunder dan bahan non hukum.
Temuan penelitian berkaitan dengan dasar dan unsur hukum mengenai tindak pidana penipuan jual beli kavling tanah yang dilakukan pengembang perumahan kepada konsumen, tertuang dalam pasal 378 KUHP dan Undang-Undang Nomor 8 Tahun 1999 tentang Perlindungan Konsumen pasal 62 serta dipenuhinya unsur tindak pidana penipuan yang dilakukan oleh pemilik PT. ABC (developer properti), sehingga perbuatannya dapat dipertanggungjawabkannya dengan pasal 378 KUHP dan Undang-Undang Nomor 8 Tahun 1999 tentang Perlindungan Konsumen pasal 62.
Rekomendasi: pertama, Dasar hukum terhadap pengembang yang melakukan penipuan jual beli tanah kavling perumahan. Kedua, Unsur-unsur tindak pidana penipuan yang dilakukan oleh pengembang perumahan . Ketiga, Pertanggung jawaban pengembang perumahan yang melakukan penipuan jual beli tanah kavling. Sejalan dengan kesimpulan diatas, diharapkan dijadikan bahan pembelajaran dan penambahan wawasan tentang pidana penipuan jual beli kavling tanah yang dilakukan pengembang perumahan kepada konsumen.
Sistem Informasi Manajemen Kegiatan UKM English Club PSDKU Polinema Di Kediri Berbasis Framework Laravel
Authors: Arya Hafizh Tofani  , Fadelis Sukya  
Published: May 2023

UKM English Club PSDKU Polinema Di Kediri saat ini belum memiliki sistem informasi untuk mengelola data kegiatan secara terintegrasi, pengelolaan data kegiatan masih menggunakan cara manual, seperti pengarsipan dibuku catatan masing-masing anggota organisasi, sehingga pengumpulan data kegiatan tidak saling terintegrasi satu dengan lainnya. Data kegiatan yang tidak saling terintegrasi akan menyebabkan kurangnya efisiensi dalam pengelolaan data kegiatan. Sehingga perlu dirancang dan dibangun sistem informasi manajemen kegiatan untuk mengelola data kegiatan UKM English Club PSDKU Polinema Di Kediri. Sistem informasi manajemen kegiatan ini dibuat dalam framework Laravel dengan basis bahasa pemrograman PHP dan menggunakan basis data PostgreSQL. Sistem informasi manajemen kegiatan ini memiliki 4 user, yaitu DPK, ketua UKM, sekretaris UKM dan admin kegiatan. Fitur aplikasi terdiri dari pengelolaan proker, persetujuan proker, pengelolaan detail proker, pengelolaan proposal kegiatan, pengelolaan LPJ kegiatan dan persetujuan proposal kegiatan telah diuji dan berhasil sesuai dengan yang diharapkan.
Peningkatan Strategi Pemasaran Ragam Olahan Susu Ronojoyo
Authors: Yanuarmawan Dion , Hamidah Fitria Nur 
Published: May 2023

Permasalahan yang dihadapi oleh Usaha Mikro dan Kecil Menengah (UMKM) ragamcamilan olahan dari susu ronojoyo (RCOS) adalah strategi atau cara bagaimana memasarkan produk yang dibuat agar masyarakat mengenal kemudian meminatinya terutama masyarakat di daerah nganjuk. RCOS berharap adanya strategi dalam memasarkan produknya untuk memudahkan usahanya dalam mengenalkan produk yang pada akhirnya akan peningkatan penjualan. Selain itu, permasalahan mengenai pembuatan laporan keuangan karena pembuatan laporan keuangan UMKM berbeda dengan laporan keuangan pada umumnya sehingga diperlukan laporan keuangan yang benar. Solusi yang dapat diberikan untuk memecahkan permasalahan di atas adalah menemukan strategi pemasaran yang tepat. “Tepat” maksudnya strategi pemasaran yang diterapkan sesuai dengan produk yang dihasilkan dan strategi bisnis yang dijalankan. Hasil yang didapat dalam pengabdian masyarakat adalah ditemukannya strategi pemasaran yang tepat yang dapat digunakan untuk memasarkan produknya dengan harapan dapat meningkatkan penjualan RCOS.
Developing Scrabble Wall for Students’ Vocabulary Learning
Authors: Sarah Fauziah  , Fitri Hilmiyati  , Siti Sa'diah  
Published: May 2023

Mastering vocabulary could be one of the keys to be successful in learning English. Teaching by using a certain game could be an interesting way to increase students’ vocabulary. The aim of this study is to create a scrabble wall to help students improve their vocabulary. This study employed the research and development method, as well as the ADDIE Model's theory, which is divided into five stages: analysis, design, development, implementation, and evaluation. Interviews, exams, and expert validation checklists were used as study instruments. This study used 25 students as a sample of product implementation among eleventh-grade students of SMA Putra Juang Cianjur. Data were gathered from student interviews, test results (Pre-test and Post-test), teacher replies, and expert validation results. The data analysis revealed that the product was both good and valid. The scrabble wall can be used as a means to teach English, particularly vocabulary. The scrabble wall is helpful for students as well. It may be concluded that the use of scrabble wall can enhance students’ vocabulary mastery.
Case report: Insulin desensitization as the only option for managing insulin allergy in a Sudanese patient
Authors: Said Rihan , Goda Rayan , Abdalrahman Ihab B. , Erwa Nahla H. H. 
Published: May 2023

IntroductionAllergic reactions to insulin have become very rare with the introduction of human insulin. Anaphylaxis is a life-threatening condition that results from immediate IgE-mediated hypersensitivity. Desensitization to human insulin was reported to control immediate hypersensitivity reactions to insulin. Here, we describe the history and challenges of managing our patient and the development of an insulin desensitization protocol in a resource-limited setup.Case SummaryA 42-year-old Sudanese woman with poorly controlled type 2 diabetes on maximum antidiabetic medications required insulin therapy to achieve reasonable glycemic control. She developed progressive and severe immediate hypersensitivity reactions to insulin, including anaphylaxis. Serum sample analysis demonstrated insulin-specific IgE antibodies. The patient's poor glycemic control and the need for breast surgery indicated insulin desensitization. A 4-day desensitization protocol was delivered in an ICU bed for close observation. Following successful desensitization and 24-h observation, our patient was discharged on pre-meal human insulin, which was tolerated well to the current dateConclusionsAlthough insulin allergy is rare, once encountered, it is very challenging in patients who have no other treatment options available. Different protocols for insulin desensitization are described in the literature; the agreed protocol was implemented successfully in our patient despite the limited resources.
Biofabrication of nanoparticles: sources, synthesis, and biomedical applications
Authors: Kulkarni Deepak , Sherkar Rushikesh , Shirsathe Chaitali , Sonwane Rushikesh , Varpe Nikita , Shelke Santosh , More Mahesh P. , Pardeshi Sagar R. , Dhaneshwar Gargee , Junnuthula Vijayabhaskarreddy , Dyawanapelly Sathish 
Published: May 2023

Graphical AbstractSources for biogenic synthesis: The synthesis sources include but are not limited to bacteria, fungi, algae, yeasts, marine and plant sources.
In silico biomechanical analysis of poller screw-assisted small-diameter intramedullary nail in the treatment of distal tibial fractures
Authors: Tan Jinchuan , Yang Yang , Wang Mian , Huang Xuecheng , Ouyang Hanbin , Zhao Dongliang , Huang Gang , Deng Yuping , Huang Wenhua 
Published: May 2023

Objective: To evaluate the biomechanical effects of Poller screws (PS) combined with small-diameter intramedullary nails in the treatment of distal tibial fractures at different locations and on different planes.Methods: Nine finite element (FE) models were used to simulate the placement of the intramedullary nail (IMN) and the PS for distal tibial fractures. Structural stiffness and interfragmentary motion (IFM) through the fracture were investigated to assess the biomechanical effects of the PS. The allowable stress method was used to evaluate the safety of the construct.Results: With the axial load of 500 N, the mean axial stiffness of IMN group was 973.38 ± 95.65 N/mm, which was smaller than that at positions A and B of the coronal group and sagittal group (p &lt; 0.05). The shear IFM of the IMN group was 2.10 ± 0.02 mm, which were smaller than that at positions A and B of the coronal group and sagittal group (p &lt; 0.05). Under physiological load, the stresses of all internal fixation devices and the nail-bone interface were within a safe range.Conclusion: In the treatment of distal tibial fractures, placing the PS in the proximal fracture block can obtain better biomechanical performance. The IMN fixation system can obtain higher structural stiffness and reduce the IFM of the fracture end by adding PS.
Nanoenhancer for improving naked DNA electrotransfection In vivo
Authors: Wang Yifei , Wang Chunxi , Sylvers Justin , Segura Tatiana , Yuan Fan 
Published: May 2023

Introduction:Electrotransfection (ET) is a non-viral approach widely used for delivery of naked nucleic acids. Its efficiency can be increasedin vitroby treatment of cells with various small molecule enhancers. However, these enhancers often fail to improve ETin vivo, presumably due to rapid clearance in tissues after local injection, reducing their cellular uptake. To this end, we propose to develop a new type of ET enhancers, which we term nanoenhancer, that diffuse slowly in tissues and are poorly absorbed by blood and lymph microvessels.Methods:Two nanoenhancers were synthesized with alginate (Alg) and chitosan (Chi) with or without poly (ethylene imine) (PEI). They were used to treat cellsin vitroor mouse muscle in the hind legin vivoprior to ET of plasmid DNA coding reporter genes. At 24 hours post ET, the efficiency of ET was quantified, and compared with that in the untreated controls. Changes in lysosomal size and acidity post nanoenhancer treatment were measured with fluorescence microscopy techniques.Results and discussion:We observed that the pretreatment of cells with the nanoenhancers could enhance the ET efficiency and cell viability in both C2C12 and HCT116 cellsin vitro, and the nanoenhancer pretreatment had similar effects on the ET efficiencyin vivo. Mechanisms of the enhancement were related to transient inactivation of lysosomal functions triggered by the nanoenhancer treatment. The concept of nanoenhancer will lead to development of new enhancers that can be used to improve ET efficiencyin vivo, highlighting its potential in clinical applications.
Comparative analysis of vaginal microbiota sampling using menstrual cups and high vaginal swabs in pregnant women living with HIV-1 infection
Authors: Short Charlotte-Eve S. , Quinlan Rachael , Lee Yun S. , Preda Veronica G. , Smith Ann , Marchesi Julian R. , Shattock Robin , Bennett Phillip R. , MacIntyre David A. , Taylor Graham P. 
Published: May 2023

BackgroundMenstrual cups (MCs) are increasingly used to collect cervicovaginal secretions to characterise vaginal mucosal immunology, in conjunction with high vaginal swabs (HVS) for metataxonomics, particularly in HIV transmission studies. We hypothesised that both methods of collecting bacterial biomass are equivalent for 16S rRNA gene sequencing.Material and MethodsCervicovaginal fluid (CVF) samples from 16 pregnant women with HIV-1 (PWWH) were included to represent the major vaginal bacterial community state types (CST I-V). Women underwent sampling during the second trimester by liquid amies HVS followed by a MC (Soft disc™) and samples were stored at -80°C. Bacterial cell pellets obtained from swab elution and MC (500 µL, 1 in 10 dilution) were resuspended in 120 µL PBS for DNA extraction. Bacterial 16S rRNA gene sequencing was performed using V1-V2 primers and were analysed using MOTHUR. Paired total DNA, bacterial load, amplicon read counts, diversity matrices and bacterial taxa were compared by sampling method using MicrobiomeAnalyst, SPSS and R.ResultsThe total DNA eluted from one aliquot of diluted CVF from an MC was similar to that of a HVS (993ng and 609ng, p=0.18); the mean bacterial loads were also comparable for both methods (MC: 8.0 log10 16S rRNA gene copies versus HVS: 7.9 log10 16S rRNA gene copies, p=0.27). The mean number of sequence reads generated from MC samples was lower than from HVS (MC: 12730; HVS:14830, p=0.05). The α-diversity metrices were similar for both techniques; MC Species Observed: 41 (range 12-96) versus HVS: 47 (range 16-96), p=0.15; MC Inverse Simpson Index: 1.98 (range 1.0-4.0) versus HVS: 0.48 (range 1.0-4.4), p=0.22). The three most abundant species observed were: Lactobacillus iners, Lactobacillus crispatus and Gardnerella vaginalis. Hierarchical clustering of relative abundance data showed that samples obtained using different techniques in an individual clustered in the same CST group.ConclusionThese data demonstrate that despite sampling slightly different areas of the lower genital tract, there was no difference in bacterial load or composition between methods. Both are suitable for characterisation of vaginal microbiota in PWWH. The MC offers advantages, including a higher volume of sample available for DNA extraction and complimentary assays.
Prognostication of treatment non-compliance among patients with multidrug-resistant tuberculosis in the course of their follow-up: a logistic regression–based machine learning algorithm
Authors: Anley Denekew Tenaw , Akalu Temesgen Yihunie , Dessie Anteneh Mengist , Anteneh Rahel Mulatie , Zemene Melkamu Aderajew , Bayih Wubet Alebachew , Solomon Yenealem , Gebeyehu Natnael Atnafu , Kassie Gizachew Ambaw , Mengstie Misganaw Asmamaw , Abebe Endeshaw Chekol , Seid Mohammed Abdu , Gesese Molalegn Mesele , Moges Natnael , Bantie Berihun , Feleke Sefineh Fenta , Dejenie Tadesse Asmamaw , Adella Getachew Asmare , Muche Achenef Asmamaw 
Published: May 2023

IntroductionDrug compliance is the act of taking medication on schedule or taking medication as prescribed and obeying other medical instructions. It is the most crucial aspect in the treatment of chronic diseases particularly for patients with multidrug-resistant tuberculosis (MDR-TB). Drug non-compliance is the main reason for causing drug resistance and poor treatment outcomes. Hence, developing a risk prediction model by using early obtainable prognostic determinants of non-compliance is vital in averting the existing, unacceptably high level of poor treatment outcomes and reducing drug resistance among MDR-TB patients.Materials and methodsA retrospective follow-up study was conducted on a total of 517 MDR-TB patients in Northwest Ethiopia. A logistic regression–based machine learning algorithm was used to develop a risk score for the prediction of treatment non-compliance among MDR-TB patients in selected referral hospitals of Northwest Ethiopia. The data were incorporated in EpiData version 3.1 and exported to STATA version 16 and R version 4.0.5 software for analysis. A simplified risk prediction model was developed, and its performance was reported. It was also internally validated by using a bootstrapping method.ResultsEducational status, registration group (previously treated/new), treatment support, model of care, and khat use were significant prognostic features of treatment non-compliance. The model has a discriminatory power of area under curve (AUC) = 0.79 with a 95% CI of 0.74–0.85 and a calibration test of p-value = 0.5. It was internally validated by using a bootstrapping method, and it has a relatively corrected discriminatory performance of AUC = 0.78 with a 95% CI of 0.73–0.86 and an optimism coefficient of 0.013.ConclusionEducational status, registration group, treatment supporter, model of care, and khat use are important features that can predict treatment non-compliance of MDR-TB patients. The risk score developed has a satisfactory level of accuracy and good calibration. In addition, it is clinically interpretable and easy to use in clinical practice, because its features are easily ascertainable even at the initial stage of patient enrolment. Hence, it becomes important to reduce poor treatment outcomes and drug resistance.
Soil gas CO2 emissions from active faults: a case study from the Anninghe—Zemuhe fault, Southeastern Tibetan Plateau, China
Authors: Liu Fengli , Zhou Xiaocheng , Dong Jinyuan , Yan Yucong , Tian Jiao , Li Jingchao , Ouyang Shupei , He Miao , Liu Kaiyi , Yao Bingyu , Wang Yuwen , Zeng Zhaojun , Zhang Yongxian 
Published: May 2023

Introduction: Carbon dioxide emissions from non-volcanic areas are undervalued in the carbon cycle.Methods: First estimates of diffuse CO2 flux from the Anninghe—Zemuhe fault (AZF), Southeastern Tibetan Plateau, China, which suggests this could equal 15% emissions from all volcanoes in China. Following the accumulation chamber method, CO2 flux was investigated at 1,483 points, and along 67 profiles crossing the AZF. Results and discussion: Total CO2 emissions from the AZF were estimated 1.2 Mt yr-1. The relationship between soil gas CO2 fluxes, earthquakes, and fault activity was discussed. The intense fault activity in the southern part of the Zemuhe fault (ZMHF) and the northern part of the Anninghe fault (ANH) was inferred, which could have enhanced the porosity of the soil, and accelerated the water-rock interactions and soil gas emission within the fault zone. The chemical and isotopic data indicated that biogenic CO2 was the primary source of CO2 from the AZF. Produced by interactions between groundwaters and carbonates, soil gas CO2 could migrate to the near surface through cracks. Spatial variations of CO2 flux in soil gas indicate that seismic activity could be responsible for the jumpy variations of CO2 flux. The diffuse CO2 from deep faults may contribute considerably to the greenhouse gas cycles.
Reinforcement mechanism analysis of lattice beam and prestressed anchor rod system for loess slope
Authors: Liu Yang , Han Dongdong , Liu Nina , Wang Wentao 
Published: May 2023

Lattice beam and prestressed anchor rod are used to enhance stability and prevent failure of soil or rock slopes. In this study, a model of Lattice beam and prestressed anchor rod (LBPAR) system was designed with reinforcement mechanisms and a model test was constructed with a circular slip surface of a loess slope. First, interaction between the loess slope and the LBPAR system was investigated by an LBPAR system analysis model. Stability of sliding mass from the sliding bed with an arc-shaped sliding surface was then studied by an experimental model designed. Finally, internal force distribution of lattice beams in the LBPAR system was investigated by using a large-scale physical model test. The results were compared to those calculated using the reverse beam method, indicating that the LBPAR system strengthened the sliding mass in space and improved the overall stability of the loess slope. With vertical loading, the axial tensile stress of the main anchor rod increases continuously. The bending area of the anchor rod was concentrated within 2 m of the sliding surface. And the maximum bending moment reaches 70 N·m. The sliding mass was subject to vertical load pressure, lattice beams’ pressure, and dead weight in the meantime and the maximum earth pressure value is near the node of the lattice beams. It is proved that such a method excels in the engineering design of loess landslides, which has promising applications in the future.