bluuebunny/crossref_metadata_2025_split huggingface dataset:
A novel application for magnetite tailings and municipal sludge in ceramsite preparation
Authors: Shi Xianfeng , Geng Chao , Li Quanming , Wei Jie , Chu Yanyu 
Published: July 2023

AbstractMagnetite tailings and municipal sludge is two different solid wastes. Large stockpiles of magnetite tailings and municipal sludge create serious environmental problems. In this study, a new method for preparing ceramsite from magnetite tailings and municipal sludge is proposed. The effects of factors including preheating temperature, preheating time, roasting temperature, roasting time, and municipal sludge dosage on the physical properties of ceramsite were investigated. The optimal conditions for ceramsite preparation were determined as follows: magnetite tailings:municipal sludge quality ratio of 85:15, preheating temperature of 325°C, preheating time of 40 min, roasting temperature of 1120°C, and roasting time of 6 min. Under these conditions, the ceramsite with an apparent density of 1.22 g/cm3, bulk density of 0.63 g/cm3, 1‐h water absorption of 3.58%, particle strength of 231 N, and cylinder pressure strength of 3.5 MPa was obtained; the resulting ceramsite met the standard requirements and was evaluated as having high quality. A toxic leaching test indicated that the ceramsite had a much lower concentration of heavy metals than the limits described by the USA Environmental Protection Agency, meeting the environmental quality standard requirements for surface water.
Probabilistic seismic performance assessment of steel moment‐resisting frames considering exposed column‐base plate connections with ductile anchor rods
Authors: Song Biao , Hassan Ahmad , Kanvinde Amit , Galasso Carmine 
Published: July 2023

AbstractThis paper presents a numerical study assessing the seismic performance of steel moment‐resisting frames (SMRFs) designed with ductile exposed column‐base plate (ECBP) connections employing yielding anchor rods. For their potential use as weak bases, the proposed ECBP detail is designed to accommodate plastic deformations in the anchors. The seismic performance of 2‐ and 4‐story archetype SMRFs with ECBPs is investigated to examine the effects of various base‐connection strengths on the frame collapse mechanisms and probabilities. To this aim, the ECBP connections of each frame are designed for a set of three strength levels, ranging from reduced seismic loads to capacity‐designed forces of the adjoining columns. These designs enable the base responses to vary from highly inelastic (i.e., weak‐base design) to elastic (i.e., strong‐base design) when subjected to earthquake‐induced ground shaking. Nonlinear time history analysis (NLTHA) is extensively performed, applying a suite of assembled ground‐motion sequences (i.e., two ground motions in series) to assess the ECBP connection response and the corresponding frame behavior. Fragility analyses accounting for only the first ground motions in each considered sequence (to derive fragility curves), and the entire ground‐motion sequences (to derive fragility surfaces) are also performed to evaluate the probabilities of frame collapse and base connection failure. Finally, key findings regarding the seismic performance of ductile ECBP connections and their effects on the frame collapse are discussed. The limitations of the study are also outlined.
Direct loss‐based seismic design of reinforced concrete frame and wall structures
Authors: Gentile Roberto , Calvi Gian Michele 
Published: July 2023

AbstractThis paper presents a procedure to design reinforced concrete (RC) buildings to achieve an acceptable target level of earthquake‐induced loss (e.g., deaths, dollars, downtime) under a site‐specific hazard profile. The procedure is called “direct” since the target loss level is specified at the first step of the process, and virtually no iteration is required. The procedure is based on a simplified loss assessment involving a surrogate model for the seismic demand (i.e., probability distribution of peak horizontal deformation given ground‐motion intensity) and simplified loss models for direct and indirect losses. For an arbitrarily‐selected target loss level and structural geometry, the procedure provides the force‐displacement curve of the corresponding equivalent single degree of freedom system. The principles of displacement‐based design are adopted to provide member detailings (beams, columns, walls) consistent with such force‐displacement curve. The procedure is applied to 16 realistic RC case studies with a lateral resisting system composed of frames in one direction and cantilever walls in the perpendicular one. They show different geometries, hazard profiles, and target values of direct economic expected annual loss. A benchmark loss estimation is obtained using cloud‐based non‐linear time‐history analyses of multi‐degree of freedom models. The procedure is conservative since the benchmark loss levels are always smaller than the targets. Such discrepancy is within 10% for 12 out of 32 case studies, between 10% and 20% for 13, between 20% and 31% for the remaining six. Therefore, the proposed procedure is deemed dependable for preliminary design.
Research on spectral method of lost circulation layer located by transient pressure wave
Authors: Wang Beijing , Zhu Zhongxi , Lei Wanneng , Wu Yanxian 
Published: July 2023

AbstractLeakage in the wellbore annulus during drilling operations can affect normal production operations, resulting in a severe waste of resources and economic loss, so it is crucial to adopt a fast and effective leak identification method for subsequent plugging operations. For the complex problem of judging the location of the leakage layer, we proposed the method of excitation pressure wave to identify the location of the leakage layer. By analyzing the transfer of pressure waves within the annular pipe system and the pressure head response spectrum, the leak's location is identified based on the location of the resonance point and the change in resonance amplitude. The pressure wave signal contains too much noise. The variational mode decomposition (VMD) algorithm and the Hilbert joint spectrum were used to extract the main frequency components to reconstruct the signal to achieve the denoising effect. On this basis, the reconstructed signal is processed by fast Fourier transform (FFT) to obtain the pressure wave response spectrum, analyze the frequency domain features, and then determine the location of the leakage layer. The experimental results verify that: ① When a leak occurs in the wellbore annulus, the pressure wave will generate additional resonance points in the frequency domain due to the presence of the leak point. ② The combination of the VMD algorithm, FFT, and Hilbert joint spectrum can effectively remove the noise of the pressure wave signal. ③ The method effectively avoids the difficulty of identifying negative pressure waves in the time domain analysis of pressure wave signals. It can effectively locate the leaky layer in the frequency domain analysis. It is concluded that the principle of the method is feasible and has practical significance for field application.
Resting state network connectivity alterations in HIV: Parallels with aging
Authors: Lew Brandon J. , McCusker Marie C. , O'Neill Jennifer , Bares Sara H. , Wilson Tony W. , Doucet Gaelle E. 
Published: July 2023

AbstractThe increasing incidence of age‐related comorbidities in people with HIV (PWH) has led to accelerated aging theories. Functional neuroimaging research, including functional connectivity (FC) using resting‐state functional magnetic resonance imaging (rs‐fMRI), has identified neural aberrations related to HIV infection. Yet little is known about the relationship between aging and resting‐state FC in PWH. This study included 86 virally suppressed PWH and 99 demographically matched controls spanning 22–72 years old who underwent rs‐fMRI. The independent and interactive effects of HIV and aging on FC were investigated both within‐ and between‐network using a 7‐network atlas. The relationship between HIV‐related cognitive deficits and FC was also examined. We also conducted network‐based statistical analyses using a brain anatomical atlas (n = 512 regions) to ensure similar results across independent approaches. We found independent effects of age and HIV in between‐network FC. The age‐related increases in FC were widespread, while PWH displayed further increases above and beyond aging, particularly between‐network FC of the default‐mode and executive control networks. The results were overall similar using the regional approach. Since both HIV infection and aging are associated with independent increases in between‐network FC, HIV infection may be associated with a reorganization of the major brain networks and their functional interactions in a manner similar to aging.
Only the fit survive recessions: Estimating labor market penalties for the obese over the business cycle
Authors: Inafuku Rachel 
Published: July 2023

AbstractThe obesity epidemic is a growing concern in the United States. Aside from the detrimental health effects of obesity, previous work has also documented a negative relationship between obesity and various labor market outcomes. Given that the American adult obesity rate is roughly 40%, obesity affects a large portion of the US labor market. In this study, I analyze the impact of obesity on income and employment over business cycle fluctuations. I find that during economic downturns, obese workers experience larger declines in income and employment relative to their healthy weight peers. These effects exist for both genders and are concentrated amongst younger adults.
Synthesis, Characterisation, and in vitro Cytotoxic Activity of Dithiocarbamato Glycoconjugate Half‐Sandwich Ruthenium and Osmium Complexes
Authors: Soldevila‐Barreda Joan J. , Pettenuzzo Andrea , Azmanova Maria , Rafols Laia , Attia Amr A. A. , Lupan Alexandru , Ronconi Luca , Barry Nicolas P. E. , Pitto‐Barry Anaïs 
Published: July 2023

AbstractThe synthesis by transmetallation and in‐depth characterisation by IR spectroscopy of five half‐sandwich ruthenium and osmium dithiocarbamato isonipecotamide glycoconjugate complexes are presented herein. The evaluation of their in vitro cytotoxicity and of the zinc precursors’ in vitro cytotoxicity towards ovarian cancer (A2780 and A2780cisR) and normal prostate (PNT2) cells is reported. While the cytotoxicity of the compounds is rather limited, some selectivity is observed.
Comparison of H‐Hayman uterine compression suture with conventional vertical sutures: A cross‐sectional study in a tertiary center
Authors: Denizli Ramazan , Farısoğulları Nihat , Sakcak Bedri , Özkavak Osman Onur , Kara Özgür , Tanaçan Atakan , Şahin Dilek 
Published: July 2023

AbstractObjectiveTo compare H‐Hayman, a modified uterine compression suturing technique (UCS) that we describe for the first time in the literature, with conventional vertical UCS techniques.MethodsThe H‐Hayman technique was used in 14 women and the conventional UCS technique in 21 women. In order to provide standardization in the study, only patients who had developed upper‐segment atony during cesarean section were recruited for the study.ResultsBleeding control was achieved in 85.7% (12/14) of the cases using the H‐Hayman technique. In the remaining two patients with persistent hemorrhage in this group, bleeding control was provided with bilateral uterine artery ligation, and a hysterectomy was avoided in all cases. With the conventional technique, bleeding control was achieved in 76.1% (16/21) of the patients, and the overall success rate was 95.2% after bilateral uterine artery ligation in those with persistent hemorrhage. In addition, the estimated blood loss and the need for erythrocyte suspension transfusion were significantly lower in the H‐Hayman group (P = 0.01 and P = 0.04, respectively).ConclusionWe found the H‐Hayman technique to be at least as successful as conventional UCS. In addition, patients who underwent suturing with the H‐Hayman technique had less blood loss and a lower requirement for erythrocyte suspension transfusion.
Loxenatide attenuates ROS‐mediated vascular endothelial progenitor cell damage and mitochondrial dysfunction via SIRT3/Foxo3 signaling pathway
Authors: Yuan Junfang , Wang Yuzhong , Wang Defeng , Yan Han , Wang Ning 
Published: July 2023

AbstractDiabetes mellitus (DM), becomes a main public health issue worldwide due to the rapid increase in DM patient numbers. The dysfunction of endothelial progenitor cells (EPCs) in DM patients plays a critical role in endothelial repair and the progression of DM‐related vascular complications. Loxenatide is an a glucagon‐like peptide 1 receptor agonist, which is used to control glycemic in type 2 diabetes patients. However, the role of Loxenatide in EPCs remains to be investigated. EPCs were isolated, characterized, and treated with Loxenatide, high‐glucose, or 3‐TYP. quantitative real‐time polymerase chain reaction, flow cytometry, western blot, and cell counting kit‐8 assay were employed to validate the expression of gene and protein expressions and cell viability, respectively. Application of Seahorse XFp to measure oxygen consumption and mitochondrial membrane potential (MMP) were measured by Seahorse XFp and MMP assay. Loxenatide attenuated high‐glucose‐induced reactive oxygen species (ROS) production and mitochondrial‐dependent apoptosis of EPCs in a concentration‐dependent manner. The EPC mitochondrial respiration dysfunction induced by high glucose was also repressed by the loxenatide treatment. The protection effect of Loxenatide on EPCs against high‐glucose was applied by activating the sirtuin 3 (SIRT3)/Foxo3 signaling pathway. We demonstrated the regulatory role of Loxenatide in mitochondrial dysfunction and apoptosis of EPCs. We elucidated that Loxenatide protects EPC from high‐glucose‐induced apoptosis via ROS‐mediated mitochondrial pathway through the SIRT3/Foxo3 signing pathway. This may provide a new therapeutical target for the treatment of DM‐related vascular complications.
Optimum collision energies for proteomics: The impact of ion mobility separation
Authors: Nagy Kinga , Gellén Gabriella , Papp Dávid , Schlosser Gitta , Révész Ágnes 
Published: July 2023

AbstractIon mobility spectrometry (IMS) is a widespread separation technique used in various research fields. It can be coupled to liquid chromatography–mass spectrometry (LC–MS/MS) methods providing an additional separation dimension. During IMS, ions are subjected to multiple collisions with buffer gas, which may cause significant ion heating. The present project addresses this phenomenon from the bottom‐up proteomics point of view. We performed LC–MS/MS measurements on a cyclic ion mobility mass spectrometer with varied collision energy (CE) settings both with and without IMS. We investigated the CE dependence of identification score, using Byonic search engine, for more than 1000 tryptic peptides from HeLa digest standard. We determined the optimal CE values—giving the highest identification score—for both setups (i.e., with and without IMS). Results show that lower CE is advantageous when IMS separation is applied, by 6.3 V on average. This value belongs to the one‐cycle separation configuration, and multiple cycles may supposedly have even larger impact. The effect of IMS is also reflected in the trends of optimal CE values versus m/z functions. The parameters suggested by the manufacturer were found to be almost optimal for the setup without IMS; on the other hand, they are obviously too high with IMS. Practical consideration on setting up a mass spectrometric platform hyphenated to IMS is also presented. Furthermore, the two CID (collision induced dissociation) fragmentation cells of the instrument—located before and after the IMS cell—were also compared, and we found that CE adjustment is needed when the trap cell is used for activation instead of the transfer cell. Data have been deposited in the MassIVE repository (MSV000090944).
Optimal delivery of endothelial progenitor cells in a rat model of critical‐size bone defects
Authors: Godbout Charles , Ryan Gareth , Ramnaraign David J. , Hegner Christian , Desjardins Sarah , Gagnon Stéphane , Bates Brent D. , Whatley Ian , Schemitsch Emil H. , Nauth Aaron 
Published: July 2023

AbstractNonunion and segmental bone defects are complex issues in orthopedic trauma. The use of endothelial progenitor cells (EPCs), as part of a cell‐based therapy for bone healing is a promising approach. In preclinical studies, culture medium (CM) is commonly used to deliver EPCs to the defect site, which has the potential for immunogenicity in humans. The goal of this study was to find an effective and clinically translatable delivery medium for EPCs. Accordingly, this study compared EPCs delivered in CM, phosphate‐buffered saline (PBS), platelet‐poor plasma (PPP), and platelet‐rich plasma (PRP) in a rat model of femoral critical‐size defects. Fischer 344 rats (n = 35) were divided into six groups: EPC+CM, EPC+PBS, EPC+PPP, EPC+PRP, PPP alone, and PRP alone. A 5 mm mid‐diaphyseal defect was created in the right femur and stabilized with a miniplate. The defect was filled with a gelatin scaffold impregnated with the corresponding treatment. Radiographic, microcomputed tomography and biomechanical analyses were performed. Overall, regardless of the delivery medium, groups that received EPCs had higher radiographic scores and union rates, higher bone volume, and superior biomechanical properties compared to groups treated with PPP or PRP alone. There were no significant differences in any outcomes between EPC subgroups or between PPP and PRP alone. These results suggest that EPCs are effective in treating segmental defects in a rat model of critical‐size defects regardless of the delivery medium used. Consequently, PBS could be the optimal medium for delivering EPCs, given its low cost, ease of preparation, accessibility, noninvasiveness, and nonimmunogenic properties.
Driving factors of soil bacterial biogeographical distribution in three alpine grassland types
Authors: Wang Qi , Chen Xiaoer , Sun Haoran , Zhou Yuting , Tao Ke , Hou Taiping 
Published: July 2023

AbstractThe biogeographic distribution of plants and animals on the Qinghai–Tibetan Plateau (QTP) has been extensively studied; however, the biogeographic patterns and factors affecting bacterial communities in alpine grassland ecosystems over large scales were not fully understood. In this paper, we explored the biogeographic patterns of soil bacterial communities in wet meadow, meadow, and steppe. The results showed that bacterial α‐diversity was similar in the three grassland types, while bacterial β‐diversity differed significantly. The dominant bacteria were Proteobacteria (29.86%), Acidobacteriota (17.76%), and Actinobacteriota (16.42%), which were caused by the changes in soil pH, C/N, and soil moisture. In addition, the significant distance–decay of bacterial communities was found across environmental and geographical distances. Partial Mantel test showed that the differences of bacterial community in wet meadow and meadow were influenced by environmental and geographical factors, while the difference of bacterial community in steppe was only affected by geographical distance. The MRM accounted for 38.7%, 37.2%, and 11.8% of the variability in wet meadow, meadow, and steppe, respectively. In wet meadow and meadow, geographic distance was the most powerful factor in explaining the similarity of bacterial communities, while soil moisture was the most critical factor in steppe. It was obvious that environmental and geographical factors played different roles in shaping structures of bacterial community in wet meadow, meadow, and steppe, which provided new insights for the effective management of alpine grassland.
Influence of the Stoichiometric Ratio on the Curing Kinetics and Mechanical Properties of Epoxy Resin Cured with a Rosin‐Based Anhydride
Authors: Rothenhäusler Florian , Kettenbach Marcel , Ruckdaeschel Holger 
Published: July 2023

AbstractBio‐based alternatives for petroleum‐based epoxy resin curing agents, such as maleopimaric acid (MPA), are indispensable for sustainable fiber reinforced polymer composites with thermosetting matrices. However, previous investigations disregarded the importance of choosing the right stoichiometric ratio R between the anhydride groups in the rosin‐based curing agent and the epoxy groups in the resin. Therefore, the influence of R on the curing kinetics and mechanical properties of an epoxy resin cured with a rosin‐based anhydride is studied. Here, Fourier‐transform infrared spectroscopy (FT–IR) indicates that for R ⩾ 0.9 unreacted anhydride groups are present in the thermoset. Consequently, the network density decreases and the glass transition temperature Tg drops by about 40 °C. On the other hand, the steric hindrance of unreacted functional groups for R ⩾ 0.9, increases the flexural modulus and the reduced network density improves fracture toughness. The results indicate that the best R for overall high mechanical performance and good processability is preferably low (R ⩽ 0.7). Here, a low R results in a high Tg and good processability due to a low viscosity. However, the latency of the mixtures is low and therefore, the mixtures are not fit for processing via prepreg technology.
Impact of nutritional‐behavioral and supervised exercise intervention following bariatric surgery: The BARI‐LIFESTYLE randomized controlled trial
Authors: Jassil Friedrich C. , Carnemolla Alisia , Kingett Helen , Doyle Jacqueline , Kirk Amy , Lewis Neville , Montagut Gemma , Marvasti Parastou , Boniface David , Brown Adrian , Chaiyasoot Kusuma , Zakeri Roxanna , Mok Jessica , Devalia Kalpana , Parmar Chetan , Batterham Rachel L. 
Published: July 2023

AbstractObjectiveThe study's aim was to investigate the impact of a 12‐month adjunctive lifestyle intervention on weight loss and health outcomes after bariatric surgery.MethodsA total of 153 participants (78.4% females; mean [SD], age 44.2 [10.6] years; BMI 42.4 [5.7] kg/m2) were randomized to intervention (n = 79) and control (n = 74). The BARI‐LIFESTYLE program combined 17 nutritional‐behavioral tele‐counseling sessions plus once‐weekly supervised exercise for 12 weeks. The primary outcome was percentage weight loss at 6 months post surgery. Secondary outcomes included body composition, physical activity levels, physical function and strength, health‐related quality of life, depressive symptomatology, and comorbidities.ResultsLongitudinal analysis of the entire cohort showed significant reductions in body weight, fat mass, fat‐free mass, and bone mineral density at the total hip, femoral neck, and lumbar spine (all p < 0.001). The 6‐minute walk test, sit‐to‐stand test, health‐related quality of life, and depressive symptomatology improved significantly (all p < 0.001). The time spent in moderate‐to‐vigorous physical activity and sedentary behavior remained the same as before surgery (both p > 0.05). There was no significant difference in the primary outcome between the intervention versus control (20.4% vs. 21.2%; mean difference = −0.8%; 95% CI: −2.8 to 1.1; p > 0.05) and no between‐group differences in secondary outcomes.ConclusionsAn adjunctive lifestyle program implemented immediately after surgery had no favorable impact upon weight loss and health outcomes.