bluuebunny/crossref_metadata_2025_split huggingface dataset:
Screening and identification of potential key biomarkers for glucocorticoid-induced osteonecrosis of the femoral head
Authors: Chen Dan , Zhong Duming , Mei Runhong , Qian Shida , Wang Peng , Chen Kaiyun , Yu Xuefeng 
Published: January 2023

Abstract
Background
Glucocorticoid-induced osteonecrosis of the femoral head (GIONFH) is a common disease in osteoarticular surgery, with a high disability rate, which brings great physical and mental pain and economic burden to patients. Its specific pathogenesis has not been fully demonstrated, and there is a lack of recognized effective biomarkers for earlier detection and prompt treatment. This has become an urgent clinical problem for orthopedic scholars.

Materials and methods
We downloaded the gene expression profile dataset GSE123568 from the Gene Expression Omnibus database, used STRING and Cytoscape to carry out module analysis and built a gene interaction network. The four core genes most related to GIONFH in this network were ultimately found out by precise analysis and animal experiment were then conducted for verification. In this verification process, thirty-six New Zealand white rabbits were randomly divided into blank control group, model group and drug group. Except for the blank control group, the animal model of GIONFH was established by lipopolysaccharide and methylprednisolone, while the drug group was given the lipid-lowering drugs for intervention as planned. The rabbits were taken for magnetic resonance imaging at different stages, and their femoral head specimens were taken for pathological examination, then the expression of target genes in the femoral head specimens of corresponding groups was detected. Validation methods included RT-PCR and pathological examination.

Results
A total of 679 differential genes were selected at first, including 276 up-regulated genes and 403 down-regulated genes. Finally, four genes with the highest degree of correlation were screened. Animal experiment results showed that ASXL1 and BNIP3L were in low expression, while FCGR2A and TYROBP were highly expressed.

Conclusion
Through animal experiments, it was confirmed that ASXL1, BNIP3L, FCGR2A and TYROBP screened from the comparative analysis of multiple genes in the database were closely related to GIONFH, which is important for early diagnosis of Glucocorticoid-induced osteonecrosis of the femoral head.
CenterTransFuser: radar point cloud and visual information fusion for 3D object detection
Authors: Li Yan , Zeng Kai , Shen Tao 
Published: January 2023

AbstractSensor fusion is an important component of the perception system in autonomous driving, and the fusion of radar point cloud information and camera visual information can improve the perception capability of autonomous vehicles. However, most of the existing studies ignore the extraction of local neighborhood information and only consider shallow fusion between the two modalities based on the extracted global information, which cannot perform a deep fusion of cross-modal contextual information interaction. Meanwhile, in data preprocessing, the noise in radar data is usually only filtered by the depth information derived from image feature prediction, and such methods affect the accuracy of radar branching to generate regions of interest and cannot effectively filter out irrelevant information of radar points. This paper proposes the CenterTransFuser model that makes full use of millimeter-wave radar point cloud information and visual information to enable cross-modal fusion of the two heterogeneous information. Specifically, a new interaction called cross-transformer is explored, which cooperatively exploits cross-modal cross-multiple attention and joint cross-multiple attention to mine radar and image complementary information. Meanwhile, an adaptive depth thresholding filtering method is designed to reduce the noise of radar modality-independent information projected onto the image. The CenterTransFuser model is evaluated on the challenging nuScenes dataset, and it achieves excellent performance. Particularly, the detection accuracy is significantly improved for pedestrians, motorcycles, and bicycles, showing the superiority and effectiveness of the proposed model.
On some new quantum trapezoid-type inequalities for q-differentiable coordinated convex functions
Authors: Wannalookkhee Fongchan , Nonlaopon Kamsing , Sarikaya Mehmet Zeki , Budak Hüseyin , Ali Muhammad Aamir 
Published: January 2023

AbstractIn this paper, we establish several new inequalities forq-differentiable coordinated convex functions that are related to the right side of Hermite–Hadamard inequalities for coordinated convex functions. We also show that the inequalities proved in this paper generalize the results given in earlier works. Moreover, we give some examples in order to demonstrate our main results.
Existence and stability analysis for a class of fractional pantograph q-difference equations with nonlocal boundary conditions
Authors: Lachouri Adel , Samei Mohammad Esmael , Ardjouni Abdelouaheb 
Published: January 2023

AbstractIn this present manuscript, by applying fractional quantum calculus, we study a nonlinear fractional pantograph q-difference equation with nonlocal boundary conditions. We prove the existence and uniqueness results by using the well-known fixed-point theorems of Schaefer and Banach. We also discuss the Ulam–Hyers stability of the mentioned pantograph q-difference problem. Lastly, the paper includes pertinent examples to support our theoretical analysis and justify the validity of the results.
General Anesthetics in CAncer REsection Surgery (GA-CARES) randomized multicenter trial of propofol vs volatile inhalational anesthesia: protocol description
Authors: Bennett-Guerrero Elliott , Romeiser Jamie L. , DeMaria Samuel , Nadler Jacob W. , Quinn Timothy D. , Ponnappan Sanjeev K. , Yang Jie , Sasson Aaron R. 
Published: January 2023

Abstract
Background
Studies indicate that patients can be “seeded” with their own cancer cells during oncologic surgery and that the immune response to these circulating cancer cells might influence the risk of cancer recurrence. Preliminary data from animal studies and some retrospective analyses suggest that anesthetic technique might affect the immune response during surgery and hence the risk of cancer recurrence. In 2015, experts called for prospective scientific inquiry into whether anesthetic technique used in cancer resection surgeries affects cancer-related outcomes such as recurrence and mortality. Therefore, we designed a pragmatic phase 3 multicenter randomized controlled trial (RCT) called General Anesthetics in Cancer Resection (GA-CARES).

Methods
After clinical trial registration and institutional review board approval, patients providing written informed consent were enrolled at five sites in New York (NY) State. Eligible patients were adults with known or suspected cancer undergoing one of eight oncologic surgeries having a high risk of cancer recurrence. Exclusion criteria included known or suspected history of malignant hyperthermia or hypersensitivity to either propofol or volatile anesthetic agents. Patients were randomized (1:1) stratified by center and surgery type using REDCap to receive either propofol or volatile agent for maintenance of general anesthesia (GA). This pragmatic trial, which seeks to assess the potential impact of anesthetic type in “real world practice”, did not standardize any aspect of patient care. However, potential confounders, e.g., use of neuroaxial anesthesia, were recorded to confirm the balance between study arms. Assuming a 5% absolute difference in 2-year overall survival rates (85% vs 90%) between study arms (primary endpoint, minimum 2-year follow-up), power using a two-sided log-rank test with type I error of 0.05 (no planned interim analyses) was calculated to be 97.4% based on a target enrollment of 1800 subjects. Data sources include the National Death Index (gold standard for vital status in the USA), NY Cancer Registry, and electronic harvesting of data from electronic medical records (EMR), with minimal manual data abstraction/data entry.

Discussion
Enrollment has been completed (n = 1804) and the study is in the follow-up phase. This unfunded, pragmatic trial, uses a novel approach for data collection focusing on electronic sources.

Trial registration
Registered (NCT03034096) on January 27, 2017, prior to consent of the first patient on January 31, 2017.
Primary hyperparathyroidism presenting as acute hypercalcemic crisis: A case report
Authors: Gill Gia , Agrawal Veena , Kerr Paul 
Published: January 2023

Background Hyperparathyroid crisis, or “parathyroid storm” is a rare manifestation of primary hyperparathyroidism, characterized by sudden onset of symptomatic, severe hypercalcemia (> 3.5 mmol/L). Hemorrhage into a parathyroid adenoma has rarely been reported as an inciting or associated event. We present a case of hemorrhage into a longstanding adenoma presenting with acute onset of profound hypercalcemia and associated complications. Case presentation A 60-year-old male presented to hospital with sudden onset of confusion, muscle weakness, and ataxia. Initial labs showed serum calcium 4.79 mmol/L, parathyroid hormone 2043 ng/L; creatinine 364 μmol/L. Review of the patient's medical history indicated a 4-year history of recurrent nephrolithiasis, but no prior documented calcium levels. The hypercalcemia did not respond to 5 days of aggressive medical management with fluid resuscitation, denosumab and calcitonin, and later pamidronate and cinacalcet. He continued to deteriorate, requiring intubation and continuous renal replacement therapy. Imaging demonstrated 4.8 cm cystic right paratracheal mass; Technetium (Tc99m) Sestamibi scintigraphy was non-localizing. Urgent parathyroidectomy was completed, revealing a 5 × 3.3 × 1.8 cm hemorrhagic, atypical hypercellular parathyroid. Unfortunately, the patient died from complications from anticoagulation therapy for treatment of deep vein thrombosis 4 weeks after admission. His renal function had not recovered at the time of his death. Conclusion This case gives potential insight into the etiology of hyperparathyroid crisis, and the difficulty in achieving control of hypercalcemia with medical means. Surgical intervention is the definitive management in these cases and should be considered urgently. Graphical abstract
Dysfunction of the glutamatergic photoreceptor synapse in the P301S mouse model of tauopathy
Authors: Arouche-Delaperche L. , Cadoni S. , Joffrois C. , Labernede G. , Valet M. , César Q. , Dégardin J. , Girardon S. , Gabriel C. , Krantic S. , Picaud S. 
Published: January 2023

AbstractTauopathies, including Alzheimer’s disease, are characterized by retinal ganglion cell loss associated with amyloid and phosphorylated tau deposits. We investigated the functional impact of these histopathological alterations in the murine P301S model of tauopathy. Visual impairments were demonstrated by a decrease in visual acuity already detectable at 6 months, the onset of disease. Visual signals to the cortex and retina were delayed at 6 and 9 months, respectively. Surprisingly, the retinal output signal was delayed at the light onset and advanced at the light offset. This antagonistic effect, due to a dysfunction of the cone photoreceptor synapse, was associated with changes in the expression of the vesicular glutamate transporter and a microglial reaction. This dysfunction of retinal glutamatergic synapses suggests a novel interpretation for visual deficits in tauopathies and it highlights the potential value of the retina for the diagnostic assessment and the evaluation of therapies in Alzheimer’s disease and other tauopathies.
The making of black inks in an Arabic treatise by al-Qalalūsī dated from the 13th c.: reproduction and characterisation of iron-gall ink recipes
Authors: Díaz Hidalgo Rafael Javier , Córdoba Ricardo , Grigoryan Hermine , Vieira Márcia , Melo Maria J. , Nabais Paula , Otero Vanessa , Teixeira Natércia , Fani Sara , Al-Abbady Hossam 
Published: January 2023

Abstract
For the first time, this paper systematises the medieval preparation of black writing inks found in the important thirteenth century Andalusian technical treatise written by Muhammad ibn Idrīs ibn al-Qalalūsī (1210–1308). We present the Arabic version of this extraordinary text (‘The gifts of the wise men on the curiosities of the substances’), and its first English translation, as well as discuss key aspects of the processes that remain missing or are unclear indications. In this work, we studied the iron gall inks based on galls, where no other phenolic source is present. In this pedagogical treatise, the recipes for these black iron-gall inks are organised and classified by the gallnuts extraction method used: boiling (decoction), squeezing and infusion, with water being the only solvent used. The inks selected were reproduced and characterised through a multi-analytical approach. Quantification was performed by HPLC–DAD (high performance liquid chromatography with diode array detectors in the UV–VIS), showing that gallic acid is a minor compound in the gall extracts prepared following al-Qalalūsī instructions. In all the recipes, the higher concentration compounds in the gall extracts are the gallotannins pentagalloylglucose and hexagalloylglucose, ranging from 79 to 50% of the phenolic compounds. This supports the results of Raman and infrared spectroscopies. A comparison with medieval Iberian recipes was also done, which served to reinforce our previous results that show water as the sole solvent extracts with much lower yields than mixed solvents (water plus white wine or vinegar).
Building a large dam: identifying the relationship between catchment area and slope using the confidence ellipse approach
Authors: Liu Suning , Chen Ji , Li Jiaye , Li Tiejian , Shi Haiyun , Sivakumar Bellie 
Published: January 2023

AbstractWith the population projections indicating continued growth during this century, construction of large dams can be considered as one of the best available options to meet the future increases in water, food, and energy demands. While there are reports that thousands of large dams will be built in the near future, a key question is: what are the appropriate conditions for selecting the sites for these dams? The site of a large dam should be carefully evaluated based on many factors, such as socioeconomic development, water resources availability, topographic characteristics, and environmental impacts. This study aims to partly address the above question through identifying the relationship between two topographic characteristics (i.e., catchment area and slope) of a river reach to build a large dam based on the 30-m-resolution global drainage networks. The information about 2815 existing large dams from the Global Reservoir and Dam (GRanD) database is collected for analysis. The confidence ellipse approach is introduced to establish the quantitative relationship between these two variables, which is then used to evaluate the site selection of a large dam from the perspective of topographic characteristics. The results show that: (1) each large dam can well correspond to the nearest river reach in the global drainage networks and (2) the logarithmic values of catchment area and slope can be well described by a confidence ellipse, which is obtained based on the means, standard deviations, and Pearson correlation coefficients of the two variables. The outcomes of this study will be of great value for policymakers to have a more comprehensive understanding of large dam development in future.
Engaging stakeholders to develop a suicide prevention learning module for Louisiana firearm training courses
Authors: Houtsma Claire , Powers Jeffrey , Raines Amanda M. , Bailey Matthew , Barber Catherine , True Gala 
Published: January 2023

Abstract
Background
Firearm suicide is a significant public health problem in the United States of America among the general and veteran populations. Broad-based preventive strategies, including lethal means safety, have been emphasized as a key approach to suicide prevention. Prior research has identified ways to improve the reach and uptake of lethal means safety messages. However, few resources have been created with these lessons in mind.

Methods
Louisiana firearm owners and instructors were recruited through a larger project, Veteran-Informed Safety Intervention and Outreach Network, as well as a publicly available database of firearm instructors to participate in focus groups to provide feedback on an existing suicide prevention learning module (developed in Utah) for use by firearm instructors. Their feedback was used to adapt the module, which included a brief video and PowerPoint presentation. Firearm owners and instructors were then invited back for another round of focus groups to provide feedback on this adapted learning module. Team-based rapid qualitative analysis was conducted to identify themes across transcripts from these four focus groups.

Results
Firearm owners and instructors agreed on several key themes, including the importance of messenger relatability and aligning the lethal means safety message with firearm owner values. Feedback suggested these themes were adequately addressed in the adapted learning module and contributed to overall module acceptability. The final theme, present across the original and adapted learning modules (i.e., Utah and Louisiana), was openness to further information and training on firearm suicide prevention.

Conclusion
Consistent with a public health approach to suicide prevention, the current study used stakeholder engagement to develop a suicide prevention learning module perceived as representative, accurate, and acceptable to Louisiana firearm owners and instructors. These findings can be used to inform firearm suicide prevention efforts in other states.
Jejunal intussusception and perforation due to enteric muco-submucosal elongated polyp: a case report and literature review
Authors: Kikuchi Ryosuke , Emoto Shigenobu , Nozawa Hiroaki , Sasaki Kazuhito , Murono Koji , Abe Shinya , Sonoda Hirofumi , Shinozaki-Ushiku Aya , Ishihara Soichiro 
Published: January 2023

Abstract
Background
A muco-submucosal elongated polyp is a non-neoplastic growth composed of mucosa and submucosa. Although muco-submucosal elongated polyps are commonly reported in the large intestine, they are rare in the small intestine, in which they are called enteric muco-submucosal elongated polyps. We herein present a case of jejunal intussusception and perforation due to an enteric muco-submucosal elongated polyp.

Case presentation
A 46-year-old woman presented with abdominal pain and vomiting. Computed tomography revealed jejunal intussusception, which was reduced via a nasointestinal ileus tube. Oral double-balloon endoscopy showed an elongated polyp in the proximal jejunum. The patient refused surgical resection and thus, the polyp was monitored. Six months later, the patient was readmitted with the recurrence of jejunal intussusception and underwent emergency surgery. Intraoperative findings revealed an intussuscepted bowel with an elongated polyp and multiple perforations in the proximal jejunum. We resected approximately 90 cm of the bowel, including the intussuscepted segment and perforated sites. The pedunculated polyp, which was 60 mm in length, was located on the oral side of the resected specimen. Histopathologically, the polyp was covered by normal mucosa and the submucosa consisted of edematous loose connective tissue. The histopathological diagnosis confirmed an enteric muco-submucosal elongated polyp.

Conclusions
Symptomatic patients with enteric muco-submucosal elongated polyps may be at risk of complications, as observed in the present case, and need to undergo timely resection.
Tax avoidance and earnings management: a neural network approach for the largest European economies
Authors: Delgado Francisco J. , Fernández-Rodríguez Elena , García-Fernández Roberto , Landajo Manuel , Martínez-Arias Antonio 
Published: January 2023

AbstractIn this study, we investigate the relationship between tax avoidance and earnings management in the largest five European Union economies by using artificial neural network regressions. This methodology allows us to deal with nonlinearities detected in the data, which is the principal contribution to the previous literature. We analyzed Compustat data for Germany, the United Kingdom, France, Italy, and Spain for the 2006–2015 period, focusing on discretionary accruals. We considered three tax avoidance measures, two based on the effective tax rate (ETR) and one on book-tax differences (BTD). Our results indicate the presence of nonlinear patterns and a positive, statistically significant relationship between discretionary accruals and both ETR indicators implying that when companies resort to earnings management, a larger taxable income—and thus higher ETR and lesser tax avoidance– would ensue. Hence, as also highlighted by the fact that discretionary accruals do not appear to affect BTD, our evidence does not suggest that companies are exploiting tax manipulation to reduce their tax payments; thus, the gap between accounting and taxation seems largely unaffected by earnings management.
Impact of Prediagnosis Risk of Major Depressive Disorder and Health-Related Quality of Life on Treatment Choice for Stage II-III Rectal Cancer
Authors: Farrell Matthew J. , Grogan Tristan R. , Raldow Ann C. 
Published: January 2023

PURPOSEWe hypothesized that depressive symptoms and health-related quality of life (HRQOL) reported by patients before their cancer diagnoses would be associated with treatment choice for stage II and III rectal cancer, specifically whether patients underwent surgery.METHODSThe Surveillance, Epidemiology, and End Results and Medicare Health Outcomes Survey linked data set was used to identify patients with stage II-III rectal adenocarcinoma diagnosed between 2004 and 2013 who had completed the health outcomes survey within 36 months before their cancer diagnoses. Risk for major depressive disorder (MDD) was determined on the basis of responses to screening questions for depressive disorders. HRQOL was assessed using the Mental Component Summary and Physical Component Summary of the 36-Item Short Form Survey and Veterans RAND 12-Item Health Survey. Using univariable and multivariable analyses, we assessed for associations between health survey responses and ultimate treatment modality.RESULTSWe identified 142 evaluable patients, of whom 109 (76.8%) underwent surgery. Thirty patients (21.1%) met criteria for being at risk for MDD before their cancer diagnoses. Patients at risk for MDD underwent surgery less often than those not at risk ( P = .0499), and this association strengthened after adjusting for patient characteristics (odds ratio, 0.17; 95% CI, 0.04 to 0.82; P = .027). There was a nonsignificant trend between higher Mental Component Summary scores (indicating higher self-reported mental HRQOL) and increased frequency of undergoing surgery ( P = .081). There were no significant associations between the Physical Component Summary and treatment modality.CONCLUSIONIn Medicare beneficiaries with stage II-III rectal cancer, those at risk for MDD underwent standard-of-care treatment with surgery less frequently. Further studies are warranted to assess the effect of mental health on clinical decision making in this patient population.