bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influence of antiresorptive/antiangiogenic therapy on changes in periodontal and oral tissue structures: a histomorphometrical analysis in rats
Authors: Ramanauskaite Ausra , Mangold Katharina , Padhye Ninad , Obreja Karina , Borschert Fanya , Dahmer Iulia , Schwarz Frank 
Published: August 2023

Abstract
Objective
The objective of this study was to investigate the influence of various antiresorptive and antiangiogenic medications on morphological changes in periodontal and oral tissue structures.
Materials and methods
Fifty-five Wistar rats randomly received dual application (i.e., at baseline and after 12-weeks) of the following medications: (1) amino-bisphosphonate [zoledronate (Zo)], (2) RANKL inhibitor [denosumab (De)], (3) antiangiogenic [bevacizumab (Be)], (4) Zo + Be, (5) De + Be or (6) no medication [Control (Co)]. Periodontal and oral tissue biopsies were obtained at 17 (n = 21 animals, Phase 1, (De = 3, De + Be = 3, Zo = 5, Be = 3, Zo + Be = 2, Co = 5) and 29 (n = 34 animals, (De = 8, De + Be = 6, Zo = 2, Be = 7, Zo + Be = 4, Co = 7, Phase 2) weeks after the second drug application. The following outcomes were histomorphometrically assessed: periodontal space width in the coronal (PLS-C, mm) and apical sections (PLS- A), number of empty alveolar bone lacunae in the coronal, apical sections and at the apex at respective tooth sites (EL – C, EL- A, EL- Ap), mucosal thickness at edentulous alveolar ridge areas (MT, mm), and, when present, associated areas of inflammatory cell infiltrates (ICI, mm2).
Results
Comparable mean PLS-C, PLS-A, ET-A, ET-C, ET-Ap, and MT values were observed in all experimental groups after Phases 1 and 2. The presence of ICI was identified in 3 animals in the Co group (Phase 1: 1, Phase 2: 2), and 17 animals in the test groups (Phase 1: 4; Phase 2: 14). The estimated ICI surface area was significantly higher in the Zo + Be group, followed by the Zo and Be groups compared to that measured in the Co group. The time (i.e., Phases 1 and 2) was not found to be a predictor for the extent of the ICI area. In all groups, the EL-C, EL-A, and EL-Ap values were significantly higher after Phase 2 compared to those assessed after Phase 1. The MT values were significantly reduced in all groups after Phase 2 compared to those measured after Phase 1.
Conclusions
The present analysis did not show any marked morphological effects of various antiresorptive and antiangiogenic medications on periodontal and oral tissue structures. The presence of inflammatory cell infiltrates was more frequently observed in the animals administered with antiresorptive and antiangiogenic medications as well as combinations thereof.
Clinical relevance:
Administration of antiresorptive and antiangiogenic medications may be capable of inducing inflammatory reactions in periodontal tissues.
Matlab Deep learning-based vehicular channel estimator in high mobility environments
Authors: Abderrahim Mountaciri , MyAbdelkader Youssefi , Elmostafa Makroum 
Published: August 2023

Abstract
communication performance in wireless networks are greatly affected by the fidelity of the channel estimator, revisiting old methods of the estimation of LS and MMSE channels by revealing their shortcomings, a new method based on deep-learning is proposed, demonstrating significant improvements in communications reliability as well as the reduction of the computational complexity of vehicular networks, under different high mobility environments ( high doppler frequency) with very short reflection times are tested by the new model Dl estimator
Who drives recent CO2 emissions in China, India and Brazil? A decomposition and decoupling analysis.
Authors: Koilakou Eleni , Hatzigeorgiou Emmanouil , Bithas Kostas 
Published: August 2023

AbstractThe study attempts to examine the driving factors of total energy-related and power-related (electricity-heat) CO2emissions for China, India and Brazil, three BRICS countries (including also Russia and South Africa) with vital economic and demographic dynamics. This paper conducts a decomposition analysis (DA) by applying the Long Mean Divisia Index (LMDI) technique for China, India and Brazil for the period of 2000–2018. The study investigates the impacts of the most prevailing factors in the released literature, as well as certain demographic ones (household size and household number) which introduced in the relevant literature for first time incorporating important social and demographic dynamics. The results show that income and population effects enlarge significantly the energy-related CO2emissions. Household size, household number and income effects are crucial for the increase of power-related CO2emissions. The crucial factors for the decrease of energy-related CO2emissions is energy intensity effect, while for power-related CO2emissions is the emission factor effect. In order to develop an integrated picture of the link between energy and economy we apply also the so-called decoupling analysis.
Why local hyper-softness is a more appropriate local reactivity descriptor than dual descriptor and Fukui function?
Authors: Martínez-Araya Jorge Ignacio 
Published: August 2023

Abstract
In this paper, the reason why local hyper-softness (LHS) allows to make comparisons of local reactivities among molecular systems of similar or different sizes as scientific literature has evidenced in the last ten years is analyzed. This lies on the fact that LHS is an intensive property. On the contrary, dual descriptor and Fukui functions are not. The Euler's homogeneous function theorem is invoked with the aim of providing a support that establishes the intensive nature of local softness and local hyper-softness, while confirming the sub-intensive feature of the Fukui functions and dual descriptors thus preventing to use these two latter for making comparisons of local reactivities among different size molecular systems.
Study of NaY@LDHs Adsorbing Low Concentration Toluene under Dry and Wet Conditions
Authors: Li Yanyao , Yin Tao , Xu Jiawen , Liu Naiwang , Shi Li , Meng Xuan 
Published: August 2023

Abstract
The industrial production process often produces VOC containing water vapor, and the adsorbent can effectively adsorb VOC. There is a competitive adsorption between water molecules and VOC molecules in the adsorption process, so it is of great significance to improve the hydrophobicity of the adsorbent. In this paper, LDHs (layered double hydroxides) were treated with aqueous miscible organic solvents and then loaded on the surface of NaY zeolite to form NaY @ LDHs core-shell structure. Nitrogen adsorption and desorption experiment, XRD characterization and toluene dynamic adsorption experiment were carried out. The results showed that when the Mg/Al molar ratio was 2:1, the LDHs treated with anhydrous ethanol had the best effect. LDHs grow vertically on the NaY zeolite to form an air layer, and the lamellar stacking generates mesopore volume, so as to effectively improve the toluene adsorption capacity and hydrophobicity.
Diagnosis and prognosis model for breast cancer based on DNAH10 which contributes to tumor immune infiltration and progression
Authors: Wang Lu , Chen Keyu , Wu Weizhu , Ding Jinhua , Zhou Yuxin , Wan Lin , Wang Xiaojia , Zhang Ziwen 
Published: August 2023

Abstract
Background Targeted therapy plays an important role in the treatment of breast cancer. However, more biomarkers are still needed to distinguish breast cancer subgroups and further achieve precise targeted therapy.Methods This study analyzed the mutation database of breast cancer and found the gene DNAH10 with high mutation frequency and significant impact on prognosis. The differential genes between the DNAH10 mutant group and the wild-type group were further analyzed, and independent prognostic factors were identified from them.Results A prognostic model was established based on CCL8, FLT3, KLHDC7B, DCD, and GBP2 genes. This model divides breast cancer patients into high-risk group and low-risk group, which has a good predictive value for the prognosis of patients. In addition, analysis of tumor immune microenvironment infiltration revealed that memory B cells, CD8 + T cells, monocytes had higher infiltration scores in the low-risk group than in the high-risk group. And both MHC I and MHC II were higher in the low-risk group. It is suggested that the low-risk group may respond better to immunotherapy. Different DNAH10 copy number variants were also associated with tumor immune microenvironment infiltration. It was further verified by in vitro experiments that DNAH10 mutation promoted tumor proliferation, invasion and migration.Conclusion Our predictive model may be an effective tool for precise diagnosis and treatment of breast cancer, helping to select populations susceptible to chemotherapy and immunotherapy.
Analysis of Policy Incentive for Chillers With Thermal Storage: a Case Study From India
Authors: Kale Shivaji , Mahesh Shelar , Sanjay Barahate , Mugdha Bhadak 
Published: August 2023

Abstract
Centralized chiller plants with thermal energy storage helps in saving electrical costs in utilities with differential tariff system but its effect on energy savings needs investigation. Even regarding cost savings, life cycle analysis is required to be done. The recent studies have highlighted the potential of energy savings from the centralized chiller plants with the thermal energy storage in commercial complexes response to the differential electricity prices. Traditionally Glycol storage is used for the diurnal load shifting in large multi-chiller plants in India. However, modeling and the dynamic analysis of these thermal storages are not reported extensively in the literature and rule of the thumb for sizing is a practice which leads to the erroneous sizing of the storage and ultimately energy losses. To help the modeling of the thermal energy storages, this paper presents the analysis of the actual data captured from the existing 1050 TR chiller plant of the commercial complex with the glycol storage. The system is analyzed for the effect of the diurnal thermal storage on the performance of the chillers and potential cost savings under various times of the day tariff rates. Deficiencies of the thermal energy storage sizing by comparing with the cooling load curve and time of day tariffs are highlighted. The over sizing of the thermal storage leads to the significant increase in energy up to 43% and cost is increased by 27%. The methodology presented here exemplified the need of fully coupled analysis of thermal storage with respect to the differential tariff and variation of COP of the system in site specific assessment
The effect of inhaled steroids on the incidence of respiratory infections in patients with asthma and COPD
Authors: hasan Layan Essam Ali , Alfawares Maamoun , Bardan Housam 
Published: August 2023

Abstract

Background
Inhaled corticosteroids (ICS) are the most effective controllers of asthma. They primarily suppress inflammation by inhibiting several activated inflammatory genes by reversing histone acetylation via histone deacetylase 2 (HDAC2). There has been significant progress in understanding the molecular mechanisms whereby ICS suppress inflammation in asthma. Progress has also been made in understanding the molecular mechanisms of corticosteroid resistance in severe asthma and chronic obstructive pulmonary disease. There is no doubt that the early use of ICS revolutionized the management of asthma, with a marked reduction in asthma morbidity and improvement in health status. The efficacy of ICS has now been emphasized in short- and long-term studies in adults and children, but there are still concerns about side effects, especially in children and when high doses of inhalation are used.
Methods and materials
An observational study of the type of cross-sectional study. This study targeted the patients of Damascus Hospital. The sample was randomly selected, and about (100) patients were selected who met specific acceptance criteria, the most important of which is the presence of adequate information in the file, while all patients were excluded according to specific criteria.
Results
In our study, the results indicated differently from previous studies in that the difference between patients who used inhalers and those who did not use inhalers is not statistically significant in either asthma or COPD patients. This is when looking at cases of developing pulmonary infections of all kinds. Our study also has several limitations related to the study pattern, small sample size, and relatively short follow-up period. It is important to note that the risks associated with the use of inhalers must be weighed against the benefits of managing asthma and COPD symptoms. Proper inhalation technique and adherence to treatment regimens can help reduce the risk of developing lung infections.
Conclusion and Recommendations
Inhalers are commonly used by patients with asthma and chronic obstructive pulmonary disease to control their symptoms. There is some concern that use of inhalers may be associated with an increased risk of lung infections in these patients. Studies have found that use of inhaled corticosteroids (ICS) may be associated with a small but statistically significant increase in the risk of developing pneumonia and lower respiratory tract infections (LRTIs) in patients with chronic obstructive pulmonary disease, but not in patients with asthma. While in the study the women from us there is no significant association. The risks associated with the use of inhalers must be weighed against the benefits of symptomatic management of asthma and COPD. Proper inhalation technique and adherence to treatment regimens can help reduce the risk of developing lung infections.
SHoC-IVC: Does assessment of the inferior vena cava by point of care ultrasound independently predict fluid status in spontaneously breathing patients with undifferentiated hypotension?
Authors: Atkinson Paul 
Published: August 2023

Abstract
Background
Accurately determining the fluid status of a patient during resuscitation in the emergency department (ED) helps guide appropriate fluid administration in the setting of undifferentiated hypotension. Our goal was to determine the diagnostic utility of point of care ultrasound (PoCUS) for inferior vena cava (IVC) size and collapsibility in predicting a volume overload fluid status in spontaneously breathing hypotensive ED patients.
Methods
This was a post-hoc secondary analysis of the SHOC-ED data, a prospective randomized controlled trial investigating PoCUS in patients with undifferentiated hypotension. We prospectively collected data on IVC size and collapsibility for 138 patients in the PoCUS group using a standard data collection form, and independently assigned a fluid status (volume overloaded, normal, volume deplete) from a composite clinical chart review blinded to PoCUS findings. The primary outcome was the diagnostic performance of IVC characteristics on PoCUS in the detection of an volume overloaded fluid status.
Results
129 patients had completed determinant IVC assessment by PoCUS, with 125 receiving successful final fluid status determination, of which 107 were classified as volume deplete, 13 normal, and 7 volume overloaded. A receiver operating characteristic (ROC) curve was plotted using several IVC size and collapsibility categories. The best overall performance utilized the combined parameters of a dilated IVC (> 2.5cm) with minimal collapsibility (less than 50%) which had a sensitivity of 85.7% and specificity of 86.4% with an area under the curve (AOC) of 0.92 for predicting an volume overloaded fluid status.
Conclusion
IVC PoCUS is feasible in spontaneously breathing hypotensive adult ED patients, and demonstrates potential value as a predictor of a volume overloaded fluid status in patients with undifferentiated hypotension. IVC size may be the preferred measure.
The limits of inductive reasoning for clinical evidence appraisal – a simulation study (Preprint)
Authors: Mickenautsch Steffen , Yengopal Veerasamy 
Published: August 2023

Abstract
Objectives
To establish the possible likelihood of a body of evidence, inductively judged to be of ‘low bias risk’/‘high-quality’ according to a limited set of appraisal criteria, of actually being error-free.
Methods
A total of 45 simulation trials were generated and randomly assigned to 0–5 errors out of a total of 65 error domains. The trials were then appraised for errors with a simulated appraisal tool consisting of five pre-specified error domains. Trial appraisal yielded either true positive, true negative, false negative or false positive results. From these values, the negative likelihood ratio (–LR) with 95% confidence interval (CI) was computed. –LR computation was repeated 25 times, each with newly generated random values for all 45 trials. The individual results of all 25 runs were statistically pooled. The pooled –LR result with 95% CI was interpreted as how likely a ‘low bias risk’/‘high-quality’ rated body of evidence is actually error-free.
Results
The pooled –LR was 0.84 (95% CI: 0.80–0.88, I2 = 0.0%). The result suggests that error-free evidence is only 1.2 times more likely to be rated as ‘low bias risk’/‘high-quality’ than evidence containing some form of error.
Conclusion
The likelihood of a ‘low bias risk’/‘high-quality’ rated body of evidence being actually error-free is small and the inductive generalisation from any limited, pre-specified set of appraisal criteria rarely justifies a high level of confidence that a ‘low bias risk’/‘high-quality’ rating of clinical evidence reflects the true effect of a certain treatment without being affected by error.
n-3 PUFAs synergistically enhance the efficacy of Doxorubicin by inhibiting the proliferation and invasion of breast cancer cells
Authors: Gurav Pradnya , Patade Tanvi , Hajare Shubham , R.N. Kedar 
Published: August 2023

Abstract
Breast cancer is a major cause of cancer-related deaths for women all over the world. It has a poor prognosis and low survival rates and is typically treated with chemotherapy. Doxorubicin (DOXO) is a potent anti-tumor agent commonly used against breast cancer. However, many patients develop resistance to treatment, leading to a higher risk of relapse and negative outcomes. N-3 polyunsaturated fatty acids are essential fatty acids. They have demonstrated potential in targeting cancerous cells, triggering apoptosis, and preventing tumor growth and spread. Combining these supplements, such as EPA/DHA with DOXO, can enhance the effectiveness of treatment. This study used the combination of DHA, EPA, and DOXO on breast cancer cell line-MCF-7. We observed a significant increase in the cytotoxicity in the combination compared to the DOXO alone. Similarly, the enhancement in the inhibition of metastasis was observed in the combination compared to the DOXO. Cell cycle study results indicated that cells treated with the combination are arrested more in the G1 phase suggesting that the combination is more effective in preventing the cells from entering into the doubling phase. Overall, the combination of n-3 polyunsaturated fatty acids (n-3 PUFAs) is effective in enhancing the effectivity of DOXO by preventing the growth and spread of breast cancer cells.
Strategies for addressing the needs of children with or at risk of developmental disabilities in early childhood by 2030: a systematic umbrella review
Authors: Smythe Tracey , Scherer Nathaniel , Nanyunja Carol , Tann Cally , Olusanya Bolajoko O. 
Published: August 2023

Abstract
Background: There are over 53million children worldwide under five with developmental disabilities, necessitating effective interventions to alleviate the impact of these conditions. However, challenges in delivering interventions persist due to various barriers, particularly in low-income and middle-income countries.
Methods: We conducted a global systematic umbrella review to assess the evidence on early detection, prevention, and rehabilitation interventions for child functioning outcomes related to developmental disabilities in children under five years. We focused on prevalent disabilities worldwide and identified evidence-based interventions at the primary, secondary, and tertiary levels. We searched Medline, Embase, PsychINFO, and Cochrane Library for relevant literature from 1st January 2013 to 14th April 2023. A narrative synthesis approach was used to summarise the findings of the included meta-analyses. The results were presented descriptively, including study characteristics, interventions assessed, and outcomes reported. Further, we presented the global prevalence of each disability in 2019 from the Global Burden of Disease study, identified the regions with the highest burden and the top ten affected countries. This study is registered with PROSPERO, number CRD42023420099.
Results: We included 18 reviews from 883 citations, which included 1,273,444 children under five with or at risk of developmental disabilities from 251 studies across 30 countries. The conditions with adequate data were cerebral palsy, hearing loss, cognitive impairment, autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder. ASD was the most prevalent target disability (n=8 reviews, 44%). Most reviews (n=12, 67%) evaluated early interventions to support behavioural functioning and motor impairment. Only 33% (n=10/30) of studies in the reviews were from middle-income countries, with no studies from low-income countries. Regarding quality, half of reviews were scored as high confidence (n=9/18, 50%), seven as moderate (39%), and two (11%) as low.
Conclusion: We identified geographical and disability-related inequities. There is a lack of evidence from outside high income settings. The study underscores gaps in evidence concerning prevention, identification, and intervention, revealing a stark mismatch between the available evidence base and the regions experiencing the highest prevalence rates.
Prevalence and Gender Differences of Emotional and Behavioral Problems Among Children With Down Syndrome
Authors: Shahzad Ruhaba , Alkarim Alyza , Iqbal Ayesha , Motiwala Oruba 
Published: August 2023

Abstract
This study aimed to shed some light on the emotional and behavioral issues faced by Down syndrome children and their gender differences. Based on evidence gathered from past research following two hypotheses were formed: There will be emotional and behavioral problems among children with Down syndrome; there will be significant gender differences in emotional and behavioral problems faced by children with Down syndrome. A total of 18 Down Syndrome children werethrough Snowball Sampling on whom The Strength and Difficulties Questionnaire was used. The findings showed no significant gender differences in emotional and behavioral problems of children with Down syndrome. However, comparatively, females were shown to have slightly elevated levels of conduct issues.