bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of cancer‐associated fibroblasts deletion using HSVtk suicide system in OSCC
Authors: Ye Chuanjin , Zhang Xiaoxin , Wang Yuhan , Jing Yue , Song Yuxian , Celentano Antonio , Ni Yanhong 
Published: May 2023

AbstractObjectiveTo evaluate the biological characteristics of oral cancer cells co‐cultured with cancer‐associated fibroblasts (CAFs)‐HSVtk and to assess the reliability of the CAFs‐HSVtk suicide system in a co‐culture model.MethodsCAFs were lentivirus‐transfected with PCDH‐HSVtk. Ganciclovir (GCV) was added and the survival rates of the CAFs‐HSVtk were measured. In parallel with the selective elimination of CAFs, comparison was made of the effects of CAF‐HSVtk on tumor cell proliferation/migration in a CAFs‐tumor co‐cultural system. Cell death of co‐cultured oral cancer cells was evaluated by flow cytometry.ResultsQ‐PCR analysis showed that the expression of HSVtk in the CAFs‐HSVtk group was significantly higher than in the control group (p < 0.01). The survival rates of CAFs‐HSVtk with GCV were significantly reduced (p < 0.01). Following selective depletion of CAFs‐HSVtk, the growth and migration rates of oral cancer cells co‐cultured with CAFs‐HSVtk were reduced in a mixture ratio of 1:2 (p < 0.01, p < 0.01).ConclusionsEnhanced proliferation and migration rates of oral cancer cells in co‐culture were seriously impaired after deleting CAFs using the HSVtk suicide system, while oral tumor cell death was not affected. Therefore, CAFs‐HSVtk can be utilized as a valid model for CAF signature identification.
Evaluation of oral health‐related quality of life in children with acute lymphocytic leukemia/acute myelocytic leukemia: A cross‐sectional study
Authors: Kilic Munevver , Gunen Yilmaz Sevcihan , Kockopru Zehra Merve 
Published: May 2023

AbstractObjectiveChemotherapy and radiotherapy, used to treat childhood hematological malignancies (acute lymphocytic leukemia [ALL] and acute myelocytic leukemia [AML]) can negatively affect oral tissues and organs. This study aimed to evaluate the oral health‐related quality of life in children with ALL/AML.Materials and MethodsA total of 99 children, including 49 undergoing ALL/AML (41 with ALL and eight with AML) and 50 healthy volunteers, were included in this cross‐sectional study. The mean age of the entire study group was 78.63 ± 34.41 months. The mean age of the ALL/AML and control groups was 87.12 ± 35.04 and 70.95 ± 34.85 months, respectively. The Simplified Oral Hygiene Index (SOHI), the Decayed, Missing, and Filled Teeth (DMFT/dmft) index, and the Turkish version of the Early Childhood Oral Health Impact Scale (ECOHIS‐T) were administered to all children. The data were analyzed using SPSS software (version 22.0). The Pearson chi‐square and Fisher's exact tests were used to compare demographic data.ResultsThe age and gender distributions of the two groups were similar. According to ECOHIS‐T, the children in the ALL/AML group had significantly more loss of function (eating, drinking, sleeping, etc.) than those in the control group.ConclusionsOral health and self‐care were negatively affected by childhood ALL/AML and its treatment.
High‐power laser photobiomodulation therapy for immediate pain relief of refractory oral mucositis
Authors: Finfter Ori , Cohen Refael , Hanut Aiham , Gavish Lilach , Zadik Yehuda 
Published: May 2023

AbstractPurposeWe aimed to evaluate the efficacy of high‐power (class IV) laser photobiomodulation (PBM) therapy for immediate pain relief due to oral mucositis (OM) refractory to recommended first‐line therapy.MethodsThis retrospective study included 25 cancer patients with refractory chemotherapy‐ or radiotherapy‐induced OM (16 and 9 patients, respectively) that were treated for pain relief with an intraoral InGaAsP diode laser (power density = 1.4 W/cm2). Pain was self‐assessed immediately before and after laser treatment using a 0‐to‐10 numeric rating scale ([NRS], “0” = no pain, “10” = intolerable pain).ResultsPatients reported an immediate decrease in pain following 94% (74 of 79) of the PBM sessions, in 61% (48 sessions) the pain reduction was over 50%, and in 35% (28 sessions) the initial pain was completely eliminated. There were no reports of increased pain post‐PBM. For chemotherapy and radiotherapy‐treated patients, mean reduction in pain NRS post‐PBM was 4.8 ± 2.5 (p < 0.001) and 4.5 ± 2.8 (p = 0.001), indicating a post‐PBM reduction of 72% and 60% of the initial pain level, respectively. The analgesic benefit of PBM remained for a mean of 6.0 ± 5.1 days. One patient reported a transient burning sensation after one PBM session.ConclusionsHigh‐power laser PBM may provide nonpharmacologic, patient‐friendly, long‐lasting, rapid pain relief for refractory OM.
Identification of genomic regions linked to blast (Pyricularia grisea) resistance in pearl millet
Authors: Pujar Mahesh , Kumar Sushil , Sharma Rajan , Ramu Punna , Babu Raman , Gupta Shashi K. 
Published: May 2023

AbstractBlast disease causes serious economic yield losses in pearl millet. Identification and introgression of genomic regions associated with blast resistance can help to develop resistant cultivars to minimize yield losses incurred from blast outbreaks. In this study, 384 advanced pearl millet genotypes were screened against six blast pathotype‐isolates (major pearl millet growing agro‐ecologies of India), namely, Pg 45, Pg 118, Pg 138, Pg 186, Pg 204 and Pg 232. Analysis of variance showed significant (P < .001) variation among genotypes for blast reaction (susceptible to resistance). ICMR 08111 and ICMR 10888 genotypes showed resistance to all six blast pathotypes. A genome‐wide association study performed with 264,241 single nucleotide polymorphic markers could successfully identify 15 SNPs (P = 1.26 × 10−7to 9.22 × 10−12) underlying the genomic regions governing blast‐resistance across five different chromosomes. The SNPs reported had a significant association in at least two of the three models tested (GLM, MLM and Farm CPU). These SNPs can be used in pearl millet‐resistant breeding programmes after their function has been validated across different genetic backgrounds.
Disruption to left inferior frontal cortex modulates semantic prediction effects in reading and subsequent memory: Evidence from simultaneous TMS‐EEG
Authors: Silcox Jack W , Mickey Brian , Payne Brennan R. 
Published: May 2023

AbstractReaders use prior context to predict features of upcoming words. When predictions are accurate, this increases the efficiency of comprehension. However, little is known about the fate of predictable and unpredictable words in memory or the neural systems governing these processes. Several theories suggest that the speech production system, including the left inferior frontal cortex (LIFC), is recruited for prediction but evidence that LIFC plays a causal role is lacking. We first examined the effects of predictability on memory and then tested the role of posterior LIFC using transcranial magnetic stimulation (TMS). In Experiment 1, participants read category cues, followed by a predictable, unpredictable, or incongruent target word for later recall. We observed a predictability benefit to memory, with predictable words remembered better than unpredictable words. In Experiment 2, participants performed the same task with electroencephalography (EEG) while undergoing event‐related TMS over posterior LIFC using a protocol known to disrupt speech production, or over the right hemisphere homologue as an active control site. Under control stimulation, predictable words were better recalled than unpredictable words, replicating Experiment 1. This predictability benefit to memory was eliminated under LIFC stimulation. Moreover, while an a priori ROI‐based analysis did not yield evidence for a reduction in the N400 predictability effect, mass‐univariate analyses did suggest that the N400 predictability effect was reduced in spatial and temporal extent under LIFC stimulation. Collectively, these results provide causal evidence that the LIFC is recruited for prediction during silent reading, consistent with prediction‐through‐production accounts.
Lifelong learning in community healthcare: Testing competence after learning activities in a blended learning space
Authors: Bing‐Jonsson Pia Cecilie , Førsund Linn Hege , Hansen Stålesen Jarle , Vabo Nesland Birgitte , Lindholm Ina Cecilie , Rugsland Espegren Olga 
Published: May 2023

AbstractAims and ObjectivesThis study reports from a municipality in Norway that implemented a competence enhancement programme for all its institutional nursing staff during the COVID‐19 pandemic to fill identified competence gaps.BackgroundMany Norwegian municipalities are experiencing a demand for expanded community healthcare services due to an increase in elderly patients and patients with extensive and complex needs. At the same time, most municipalities are striving to recruit and keep competent health personnel. New ways of organising and increasing the competence of the workforce may help ensure that the healthcare delivered corresponds to patients' changing needs.Design and MethodsNursing staff were encouraged to complete targeted competence enhancing activities with the aim of enhancing their competence in identified areas. The learning activities were blended and consisted of e‐learning courses, lectures, supervision, vocational training and meetings with a superior. Competence was measured before and after the competence enhancing activities (n = 96). The STROBE checklist was applied.ResultsThe results provide insight into the competence development of registered nurses and assistant nurses in institutional community health services. They show that the implementation of a workplace‐based blended learning programme improved competence significantly, especially for assistant nurses.ConclusionsOffering workplace‐based competence enhancing activities seems to be a sustainable way of facilitating lifelong learning among nursing staff. Facilitation of learning activities in a blended learning space may enhance accessibility and increase the potential for participation. A combination of reorganisation of roles and simultaneous competence enhancing activities can ensure that both managers and nursing staff prioritise filling competence gaps.
Conditions of submarine levéed channel inception: Examination by flume experiments
Authors: Poppeschi Justine , Nakata Kazushi , Naruse Hajime 
Published: May 2023

ABSTRACTSubmarine levéed channels are often observed in submarine fans, although submarine fans without continuous levéed channels are also common depending on the composition of supplied sediments, particularly the proportion of muddy/sandy materials. However, parameters governing the inception of levéed channels have not yet been studied. Furthermore, depositional levéed channel topography has not been simulated in experimental flumes in any previous study conducted with dilute flows (flow concentration <10%). Herein, four experimental series were conducted (Series A, B, C and D) to simulate depositional submarine channels and to study their formative conditions. A mixture of sediment and saline water was used in the experiments, and both the width of an outlet diffuser and flow discharge rate were varied in the experimental series. A topography composed of a channel with two ridges resembling natural depositional submarine channels with levées was formed in all experiments. Comparisons between the experimental topographies and natural submarine fans revealed that two of the four experimental series produced channel levées with length to width ratios similar to those produced by natural systems. An experiment with half the outlet size produced a channel two times deeper (4.5 cm against 2.0 cm and 2.2 cm) as compared to other experiments. The flow discharge rate and outlet width were half of those observed in Series A and B. Furthermore, salt was removed from the initial mixture for one of the experiments, resulting in high natural levées with a short channel. This study demonstrated that dilute flows could form purely depositional channel levées without precursor or resultant erosive features. In addition, results revealed that the formation of submarine channels is related to two factors: channel width and muddy suspended sediment.
The politics of disaggregated family policy: The role of party ideology and women's political representation in governments
Authors: Wiß Tobias , Wohlgemuth Felix 
Published: May 2023

AbstractAlthough affluent democracies experienced family policy expansion, there are remarkable country differences. Whilst some countries focus on policies supporting the male breadwinner model such as family allowances, others prioritise gender equality supporting public childcare. We explain this variation by arguing for governments as key actors in parliamentary democracies and test two sets of explanations: party ideology and women's representation. Our error correction models covering 16 affluent parliamentary democracies between 1991 and 2015 reveal that non‐left rather than left parties matter for family policy. Secular centre and Christian‐Democratic parties promote father‐specific leave, whilst secular right parties reduce spending on childcare and family allowances as well as father‐specific leave. The share of female ministers is associated with higher childcare expenses, and instead of women's share, the gender of the family affairs minister affects father‐specific leave expansions.
Duration of continuous cropping with straw return affects soil organic carbon
Authors: Zhang Jun , Zhang Fenghua , Chang Handa 
Published: May 2023

AbstractUnderstanding the impact of continuous cropping with straw return on soil organic matter functional groups is of great importance for maintaining chemical stabilization of SOC in arid regions. Infrared spectral characteristics of cotton field soil with different continuous cropping durations (0, 5, 10, 15 and 20 years) were determined with Fourier‐transform infrared spectroscopy for fields in Manasi River Basin, Xinjiang province, China. The effects of continuous cropping duration on the stability and chemical composition of soil organic carbon (SOC) were analysed. The results indicate an initial increase in the SOC, soil particulate organic carbon (POC), and mineral‐associated organic carbon (MOC) content of soil under continuous cropping with straw return. However, as continuous cropping duration increased, the levels of SOC, POC, and MOC in soil began to decrease. The soil POC content and POC/MOC were highest after 5 years of straw return, and started to decrease as the continuous cropping duration increased. The SOC and MOC contents were highest after 10 years of continuous cropping, and were 3.30 and 1.84 times higher than the control, respectively. As continuous cropping duration increased, the relative peak intensities for polysaccharides and aromatic groups in soil organic matter decreased, while the relative peak intensities for aliphatic compounds and hydroxyketone increased. In conclusion, continuous cropping with straw return in cotton fields promotes SOC but only for about 10 years. An increase in straw return duration boosts the degree of esterification in soil organic matter. Moreover, enhanced protection by mineral binding was observed for soil organic matter, increasing organic matter stabilization. This study aimed to provide an empirical foundation for the management of the SOC pool and the establishment of rational straw return practices for cotton fields in arid areas.
Effect of calcareous and siliceous amendments onN2Oemissions of a grassland soil
Authors: Vekic Teodora Todorcic , Nadeem Shahid , Molstad Lars , Martinsen Vegard , Hiis Elisabeth Gautefall , Bakken Lars , Rütting Tobias , Klemedtsson Leif , Dörsch Peter 
Published: May 2023

AbstractLiming of acidic agricultural soils has been proposed as a strategy to mitigate nitrous oxide (N2O) emissions, as increased soil pH reduces the N2O/N2product ratio of denitrification. The capacity of different calcareous (calcite and dolomite) and siliceous minerals to increase soil pH and reduce N2O emissions was assessed in a 2‐year grassland field experiment. An associated pot experiment was conducted using homogenized field soils for controlling spatial soil variability. Nitrous oxide emissions were highly episodic with emission peaks in response to freezing–thawing and application of NPK fertilizer. Liming with dolomite caused a pH increase from 5.1 to 6.2 and reduced N2O emissions by 30% and 60% after application of NPK fertilizer and freezing–thawing events, respectively. Over the course of the 2‐year field trial, N2O emissions were significantly lower in dolomite‐limed than non‐limed soil (p < .05), although this effect was variable over time. Unexpectedly, no significant reduction of N2O emission was found in the calcite treatment, despite the largest pH increase in all tested minerals. We tentatively attribute this to increased N2O production by overall increase in nitrogen turnover rates (both nitrification and denitrification) following rapid pH increase in the first year after liming. Siliceous materials showed little pH effect and had no significant effect on N2O emissions probably because of their lower buffering capacity and lower cation content. In the pot experiment using soils taken from the field plots 3 years after liming and exposing them to natural freezing–thawing, both calcite (p < .01) and dolomite (p < .05) significantly reduced cumulative N2O emission by 50% and 30%, respectively, relative to the non‐limed control. These results demonstrate that the overall effect of liming is to reduce N2O emission, although high lime doses may lead to a transiently enhanced emission.
Needle tract seeding and malignant transformation of hepatocellular adenoma into well‐differentiated hepatocellular carcinoma in a dog
Authors: Jornet‐Rius Oriol , Agulla Beatriz , López María Cristina , Viñeta Claudia , García‐Ferrer Alicia , Serrano Bárbara , Marco Alberto , Palomares Anna , Novellas Rosa , Espada Yvonne , Roura Xavier , Solano‐Gallego Laia 
Published: May 2023

AbstractAn 11‐year‐old neutered female Golden Retriever was referred for investigation of marked increases in liver enzyme activities. Abdominal ultrasound revealed a large pedunculated liver mass. Diagnosis of hepatocellular adenoma (HCA) was made when the mass was excised after a first unsuccessful attempt through ultrasound‐guided core‐needle biopsy. One and a half years after presentation, a nodule embedded between muscles of the abdominal wall appeared. The mass was first diagnosed as a well‐differentiated hepatocellular carcinoma (HCC) through cytologic examination, which was later confirmed with histopathology. Ki 67 immunostaining of the abdominal wall nodule showed an increased immunoreactivity compared with the liver mass. Therefore, the present case documents the first needle‐tract seeding of a hepatocellular epithelial tumor with possible malignant transformation of HCA into a well‐differentiated HCC in a dog.
Delayed non‐selective contrast‐enhanced CT can reveal spontaneous contrast enhancement of the lymphatic system in cats
Authors: Guarnera Isabella , Cordella Alessia , Specchi Swan , Bertolini Giovanna 
Published: May 2023

AbstractThe authors incidentally observed that, on delayed postcontrast CT studies, feline patients could show increased attenuation of the lymphatic system. The aim of the present study was to evaluate if the lymphatic system of feline patients undergoing intravenous administration of contrast medium might consistently enhance on delayed postcontrast CT studies. Feline patients that underwent CT examination for variable diagnostic purposes were included in this multicentric observational descriptive study. A 10‐min delayed postcontrast whole‐body CT series was obtained for all cats enrolled and the following anatomic structures were systematically assessed: mesenteric lymphatic vessels, hepatic lymphatic vessels, cisterna chyli, thoracic duct, and anastomosis of the thoracic duct with the systemic venous system. A total of 47 cats were included in the study. The mesenteric lymphatic vessels showed enhancement in the selected series in 39 of 47 (83%) patients and the hepatic lymphatic vessels in 38 of 47 (81%) patients. The cisterna chyli, thoracic duct, and the point of anastomosis of the thoracic duct with the systemic venous circulation were enhanced in 43 (91%), 39 (83%), and 31 of 47 (66%) cats, respectively. This study confirms the initial observation. The mesenteric and hepatic lymphatic system, the cisterna chyli, the thoracic duct, and its anastomosis with the systemic venous circulation of feline patients undergoing intravenous administration of iodinated contrast medium can show spontaneous contrast enhancement in non‐selective 10‐min delayed contrast‐enhanced CT series.
Big Data and Innovative Research Methods
Authors: Mamo Yoseph Z. 
Published: May 2023

Big data and innovative research methods are two rapidly evolving trends that are transforming how we conduct research in sport management. Considering the natural relationship between social media, which is widely recognized as a major big-data source, and sport, this commentary centers on contemporary research method applied to social media data. In doing so, it discusses contemporary innovative techniques for social media data, focusing on exploring ways to access social media data, the natural language-processing techniques used, the challenges they address, the strengths and limitations of different techniques, and the ethical and privacy considerations associated with their use. Furthermore, the commentary demonstrates that using sentiment-analysis tools (e.g., Syuzhet, Bing, and AFFIN) is appropriate and efficient in analyzing sport’s social media data. Thus, a rigorous application of contemporary innovative techniques can significantly shape the future of sport management research. However, researchers must exercise caution when considering the source and preprocessing of the data prior to applying advanced analytical techniques.
Supplemental Material: Ibex Hollow Tuff from ca. 12 Ma supereruption, southern Idaho, identified across North America, eastern Pacific Ocean, and Gulf of Mexico
Authors: Sarna-Wojcicki Andrei M. , al. et 
Published: May 2023

<p>Item S1 (MS Word document): Detailed methods for major, minor, and trace-element analysis; electron-microprobe analysis (EMA); instrumental neutron activation analysis (INAA); laser ablation–inductively coupled–mass spectrometry (LA-ICP-MS); isothermal-plateau fission-track method of age determination; correlation methods; references cited for methods section. Item S2: Table of major– and minor–EMA analyses of individual glass shards of tephra beds correlated to Ibex Hollow Tuff; contains plots of Fe<sub>2</sub>O<sub>3</sub> versus CaO for samples. Item S3: Table of major– and minor–EMA analyses of individual glass shards of tephra beds of the Ibex Hollow Tuff, performed at the U.S. Geological Survey, Menlo Park, California. Initial compositions and totals on analysis are presented, with plots of Fe<sub>2</sub>O<sub>3</sub> versus CaO. Item S4: Table of major– and minor–EMA analyses of individual glass shards of tephra beds that correlate with the Ibex Hollow Tuff. Initial compositions and totals on analysis are presented, with plots of Fe<sub>2</sub>O<sub>3</sub> versus CaO. Item S5: Binary graphic plots of major oxides and elements of the Ibex Hollow Tuff and overlying and underlying tephra layers at Trapper Creek, Idaho, USA. </p>