bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of fluvoxamine on plasma interleukin-6 in patients with major depressive disorder: a prospective follow-up study
Authors: Li Xueqin , Yan Danfeng , Liao Mei , Zhang Li , Li ZeXuan , Liu Bangshan , Chen Yanjun , Zhang Yan , Liu Jin , Li LingJiang 
Published: May 2023

IntroductionMajor depressive disorder (MDD) is associated with low-grade inflammation, and anti-inflammatory treatment can help improve depressive symptoms. A recent study found that fluvoxamine (FLV) can reduce Interleukin-6 (IL-6) production via sigma-1 receptor in inflammation models. However, the anti- IL-6 effect of FLV in treating patients with MDD and whether it can contribute to antidepressant effects remain unclear.MethodsA total of 65 patients with MDD and 34 healthy controls were recruited at baseline, and 50 patients completed the FLV treatment for 2 months. We assessed depression and anhedonia and collected plasma IL-6 levels at baseline, 1 month, and 2 months after baseline. This study evaluated the changes in clinical measures and IL-6 during treatment and analyzed their association. Further subgroup analyses were conducted in patients with MDD with high, medium, or low IL-6.ResultsDepression and anhedonia were significantly improved in patients with MDD, while the IL-6 did not significantly change after the FLV treatment. However, IL-6 significantly declined after the FLV treatment among patients with MDD with higher baseline IL-6. No significant associations were found between the changes in depressive symptoms and IL-6.ConclusionOur study provided preliminary evidence suggesting that the anti-IL-6 effect of FLV might not play a vital role in its antidepressant treatment, at least in patients with MDD with low inflammation. However, for patients with MDD with higher IL-6, FLV can help reduce IL-6 significantly in the antidepressant treatment, which may help guide the individual treatment of MDD with higher IL-6 levels.Clinical trial registrationhttps://clinicaltrials.gov/ct2/show/NCT04160377, identifier NCT04160377.
Women's perspectives on human milk banking in Ghana: results from a cross-sectional study
Authors: Obeng Cecilia , Jackson Frederica , Amissah-Essel Salome , Nsiah-Asamoah Christiana , Perry Cydne A. , Gonzalez Casanova Ines , Obeng-Gyasi Emmanuel 
Published: May 2023

BackgroundAlthough political and academic interest exists in Ghana to include human milk banks (HMB) into current maternal and child health programs, efforts to establish a HMB have not yet been subjected to any real empirical inspection with the view toward implementation. Furthermore, views toward the establishment of a HMB in Ghana have not been assessed among Ghanaian women. The aims of the current study were to examine Ghanaian women's views about HMB, and to investigate women's willingness to donate to a HMB.MethodsQuantitative and qualitative responses were received from Ghanaian females (n = 1,270) aged 18+ years. Excluding outliers and missing data (n = 321), a final sample of 949 was retained for final analysis. Chi-square tests and logistic regression analysis were computed on quantitative data; Thematic analysis was performed on the qualitative responses.ResultsIn our sample, 64.7% of respondents indicated that Ghana is ready for a HMB. The majority (77.2%) were willing to donate milk, and 69.4% believed that donating to the HMB would favor their child. The main concerns for the unwillingness to donate excess milk included: (i) the idea of HMBs as strange/bizarre (n = 47), (ii) fear of infections (n = 15), (iii) religious beliefs (n = 9), and (iv) insufficient information (n = 24). This study serves as the first step toward the development of a HMB in Ghana.ConclusionsOverall, Ghanaian women support the building of a HMB to enhance infant nutrition and reduce childhood morbidity and mortality.
Universal coverage and utilization of free long-lasting insecticidal nets for malaria prevention in Ghana: a cross-sectional study
Authors: Afagbedzi Seth Kwaku , Alhassan Yakubu , Kenu Ernest , Malm Keziah , Bandoh Delia Akosua Benewaah , Peprah Nana Yaw , Ansah Otubea Owusu , Guure Chris 
Published: May 2023

BackgroundMalaria continues to be one of the leading causes of mortality and morbidity, especially among children and pregnant women. The use of Long-Lasting Insecticide Nets (LLINs) has been recognized and prioritized as a major intervention for malaria prevention in Ghana. This study aims to establish the factors influencing the universal coverage and utilization of LLINs in Ghana.MethodsThe data used for this study was from a cross-sectional survey carried out to assess LLINs ownership and use in 9 out of the 10 old regions of Ghana from October 2018 to February 2019 where free LLIN distribution interventions were implemented. The EPI “30 × 7” cluster sampling method (three-stage sampling design) was modified to “15 × 14” and used for the study. A total of 9,977 households were interviewed from 42 districts. Descriptive statistics using percentages as well as tests of associations such as Pearson Chi-square and the magnitude of the associations using simple and multivariable logistic regression were implemented.ResultsOf the 9,977 households in the study, 88.0% of them owned at least one LLIN, universal coverage was 75.6%, while utilization was 65.6% among households with at least one LLIN. In the rural and urban areas, 90.8% and 83.2% of households, respectively, owned at least one LLIN. The was a 44% increase in universal coverage of LLINs in rural areas compared to urban areas (AOR: 1.44, 95% CI: 1.02–2.02). There were 29 higher odds of households being universally covered if they received LLIN from the PMD (AOR: 29.43, 95% CI: 24.21–35.79). Households with under-five children were 40% more likely to utilize LLIN (AOR: 1.40, 95% CI: 1.26–1.56). Respondents with universal coverage of LLIN had 25% increased odds of using nets (AOR: 1.25 95% CI: 1.06–1.48). Rural dwelling influences LLIN utilization, thus there was about 4-fold increase in household utilization of LLINs in rural areas compared to urban areas (AOR: 3.78, 95% CI: 2.73–5.24). Household size of more than 2 has high odds of LLINs utilization and awareness of the benefit of LLINs (AOR: 1.42, 95% CI: 1.18–1.71).ConclusionAbout nine in 10 households in Ghana have access at least to one LLIN, three-quarters had universal coverage, and over two-thirds of households with access used LLIN. The predictors of universal coverage included region of residence, rural dwellers, and PMD campaign, while households with child under-five, in rural areas, and with universal coverage were positively associated with utilization.
Nationwide projections of ischemic stroke with large vessel occlusion of the anterior circulation by 2050: Dijon Stroke Registry
Authors: Duloquin Gauthier , Béjot Yannick 
Published: May 2023

IntroductionData on the epidemiology of ischemic stroke (IS) with large vessel occlusion (LVO) are scarce although there is a need to better assess future demands for dedicated facilities in an aging population. This study aimed to estimate the number of expected cases of IS with LVO of the anterior circulation in the French population by 2050.MethodsIS were retrieved from the population-based registry of Dijon, France (2013–2017). Patients with LVO were identified and age-and sex-standardized incidence rates were calculated to estimate the number of expected cases in the whole French population by 2050 according three scenarios: stable incidence; a decrease in incidence rates of 0.5%/year in people &gt;65 years old; a decrease in incidence rates of 0.5%/year in overall population.Results1,067 cases of IS with LVO were recorded in Dijon over the study period, corresponding to crude incidence rate of 22/100,000/year (95% CI: 18–25). By 2050, the number of cases is expected to increase by 51 to 81% according to the various scenarios, to reach between 22,457 cases (95% CI: 10,839 – 43,639) and 26,763 cases (95% CI: 12,918 – 52,008) annually. This increase will be mainly driven by patients &gt;80  years old, with a rise of cases between +103% and +42% in this age group. The proportion of patients &gt;80 years old among overall IS with LVO will increase from 43 to 57% approximately.ConclusionThe expected massive increase in IS with LVO highlights the need for a rapid action to cover stroke care requirements.
Factors influencing the participation of groups identified as underserved in cervical cancer screening in Europe: a scoping review of the literature
Authors: Greenley Rachel , Bell Sadie , Rigby Samuel , Legood Rosa , Kirkby Victoria , McKee Martin ,   the CBIG-SCREEN Consortium
Published: May 2023

BackgroundCervical cancer is a preventable and inequitably distributed disease. Screening plays a vital role in prevention, but many women face barriers to participation. The aims of this scoping review, undertaken to inform the co-design of interventions to equitably increase screening uptake, were to: (1) identify barriers and facilitators to cervical cancer screening for underserved populations, and (2) identify and describe the effectiveness of interventions aimed at improving participation in cervical cancer screening among underserved groups in Europe.MethodsQualitative, quantitative, and mixed methods studies focusing on barriers and facilitators to cervical screening participation and interventions to improve uptake undertaken in Europe and published after 2000 were included. Four electronic databases were searched to identify relevant papers. Titles and abstracts were screened, full text reviewed, and key findings extracted. Data were extracted and analyzed according to different health system strata: system-wide (macro), service specific (meso) and individual/community specific (micro). Within these categories, themes were identified, and the population groups impacted were recorded. All findings are presented in accordance with (PRISMA) guidelines.Results33 studies on barriers and facilitators and eight intervention studies met the inclusion criteria. Collectively, the findings of these studies presented a wide array of screening uptake barriers, facilitators, and interventions, predominantly related to screening service and individual/community factors. However, although diverse, certain core themes around information provision, prompts for participation and the need for inclusive spaces were apparent. Implementation of screening programs should focus on: (1) reducing identifiable barriers, (2) increasing public awareness, and (3) providing patient reminders and measures to promote engagement by healthcare providers.ConclusionThere are many barriers to uptake of cervical cancer screening and this review, nested within a larger study, will inform work to devise a solution alongside groups identified in three European countries.
Association between upper limb movements during drumming and cognition in older adults with cognitive impairment and dementia at a nursing home: a pilot study
Authors: Miyazaki Atsuko , Ito Yuichi , Okuyama Takashi , Mori Hayato , Sato Kazuhisa , Ichiki Masahiko , Hiyama Atsushi , Dinet Jerome , Nouchi Rui 
Published: May 2023

BackgroundDespite the association between motor dysfunction and dementia, quantitative assessment of dementia-related specific motor dysfunction in patients with severe dementia is difficult. Thus, this study aimed to develop a new method to measure upper limb motor function in people with dementia.MethodsWe examined the relationship between dementia severity and dementia-related specific motor dysfunction using the Mini-Mental State Examination (MMSE), a dementia screening test. Participants comprised 16 nursing home residents with a mean age of 86 years and MMSE score of 14.56 (range, 1–23) Points. Participants were seated in a circle and instructed to play a drum that was placed in their lap using mallets (drumsticks) in their dominant hand. Acceleration and gyroscopic sensors were attached to their wrists to collect data on arm movements while drumming. Upper limb motor characteristics were confirmed by recording acceleration and arm movement during drumming and analyzing the correlation with handgrip strength.ResultsHandgrip strength was correlated with arm elevation angle during drumming. The arm elevation angle displayed a significant regression equation with the MMSE score and showed the best regression equation along with handgrip strength (adjusted R2 = 0.6035, p = 0.0009).ConclusionWe developed a new method using drums to measure upper limb motor function in people with dementia. We also verified that the average arm elevation angle during drumming could predict cognitive dysfunction. This system may be used to monitor people with dementia in a simple and safe way.
The effects of sleep and targeted memory reactivation on the consolidation of relevant and irrelevant information
Authors: Barner Christine , Werner Ann-Sophie , Schörk Sandra , Born Jan , Diekelmann Susanne 
Published: May 2023

IntroductionSleep is assumed to facilitate the consolidation of new memories in an active process of covert reactivation of the underlying memory representations. Recent evidence suggests that this process is selective by favoring memories that are of future relevance, and can be externally triggered by learning-associated sensory cues presented during sleep [i.e., targeted memory reactivation (TMR)]. In the present study, we (1) set out to confirm the preferential sleep effect for relevant information, and then asked whether (2) simultaneous TMR of relevant and irrelevant information facilitates the advantage for relevant information, and (3) whether the preferential benefit of sleep and TMR for relevant information persists over time.MethodsTo test these questions, participants explicitly learned two sets of picture-location associations, of which one set was instructed (after encoding) to be relevant and the other to be irrelevant for later testing. In Experiment 1, memory was tested after ~12 h of night sleep (n = 28) or daytime wakefulness (n = 28) as well as again after ~1 week.ResultsResults showed overall better memory retention after sleep compared to wakefulness after 12 h as well as after 1 week. The relevant memories were overall retained better than the irrelevant memories. Interestingly, a trend toward a stronger sleep benefit for the relevant memories emerged after 1 week, although this effect failed to reach significance. In Experiment 2, learning of the relevant and irrelevant picture-location associations took place in the presence of an odor. During subsequent sleep, in the first phase of slow wave sleep (SWS), participants were either presented with the odor again (n = 23) or received an odorless vehicle (n = 20). Memory retention was assessed after the first SWS period (following awakening) as well as after ~one week. As in Experiment 1, relevant memories were overall retained better than irrelevant memories. However, TMR did not differentially affect the retention of relevant and irrelevant memories.DiscussionThese findings provide tentative evidence that the selective benefit of sleep for relevant memories evolves over time but is not further facilitated by TMR.
Faster recovery and bowel movement after early oral feeding compared to late oral feeding after upper GI tumor resections: a meta-analysis
Authors: Sindler Dóra Lili , Mátrai Péter , Szakó Lajos , Berki Dávid , Berke Gergő , Csontos Armand , Papp Csenge , Hegyi Péter , Papp András 
Published: May 2023

BackgroundThere were more than 1 million new cases of stomach cancer concerning oesophageal cancer, there were more than 600,000 new cases of oesophageal cancer in 2020. After a successful resection in these cases, the role of early oral feeding (EOF) was questionable, due to the possibility of fatal anastomosis leakage. It is still debated whether EOF is more advantageous compared to late oral feeding. Our study aimed to compare the effect of early postoperative oral feeding and late oral feeding after upper gastrointestinal resections due to malignancy.MethodsTwo authors performed an extensive search and selection of articles independently to identify randomized control trials (RCT) of the question of interest. Statistical analyses were performed including mean difference, odds ratio with 95% confidence intervals, statistical heterogeneity, and statistical publication bias, to identify potential significant differences. The Risk of Bias and the quality of evidence were estimated.ResultsWe identified 6 relevant RCTs, which included 703 patients. The appearance of the first gas (MD = −1.16; p = 0.009), first defecation (MD = −0.91; p &lt; 0.001), and the length of hospitalization (MD = −1.92; p = 0.008) favored the EOF group. Numerous binary outcomes were defined, but significant difference was not verified in the case of anastomosis insufficiency (p = 0.98), pneumonia (p = 0.88), wound infection (p = 0.48), bleeding (p = 0.52), rehospitalization (p = 0.23), rehospitalization to the intensive care unit (ICU) (p = 0.46), gastrointestinal paresis (p = 0.66), ascites (p = 0.45).ConclusionEarly postoperative oral feeding, compared to late oral feeding has no risk of several possible postoperative morbidities after upper GI surgeries, but has several advantageous effects on a patient's recovery.Systematic Review Registrationidentifier, CRD 42022302594.
Dietary replacement of inorganic trace minerals with lower levels of organic trace minerals leads to enhanced antioxidant capacity, nutrient digestibility, and reduced fecal mineral excretion in growing-finishing pigs
Authors: Xiong Yunxia , Cui Bailei , He Zhentao , Liu Shuai , Wu Qiwen , Yi Hongbo , Zhao Fei , Jiang Zongyong , Hu Shenglan , Wang Li 
Published: May 2023

IntroductionMore effective and environment-friendly organic trace minerals have great potential to replace the inorganic elements in the diets of livestock. This study aimed to investigate the effects of dietary replacement of 100% inorganic trace minerals (ITMs) with 30–60% organic trace minerals (OTMs) on the performance, meat quality, antioxidant capacity, nutrient digestibility, and fecal mineral excretion and to assess whether low-dose OTMs could replace whole ITMs in growing-finishing pigs' diets.MethodsA total of 72 growing-finishing pigs (Duroc × Landrace × Yorkshire) with an initial average body weight of 74.25 ± 0.41 kg were selected and divided into four groups with six replicates per group and three pigs per replicate. The pigs were fed either a corn-soybean meal basal diet containing commercial levels of 100% ITMs or a basal diet with 30, 45, or 60% amino acid-chelated trace minerals instead of 100% ITMs, respectively. The trial ended when the pigs' weight reached ~110 kg.ResultsThe results showed that replacing 100% ITMs with 30–60% OTMs had no adverse effect on average daily gain, average daily feed intake, feed/gain, carcass traits, or meat quality (P &gt; 0.05) but significantly increased serum transferrin and calcium contents (P &lt; 0.05). Meanwhile, replacing 100% ITMs with OTMs tended to increase serum T-SOD activity (0.05 ≤ P &lt; 0.1), and 30% OTMs significantly increased muscle Mn-SOD activity (P &lt; 0.05). Moreover, replacing 100% ITMs with OTMs tended to increase the apparent digestibility of energy, dry matter, and crude protein (0.05 ≤ P &lt; 0.1) while significantly reducing the contents of copper, zinc, and manganese in feces (P &lt; 0.05).DiscussionIn conclusion, dietary supplementation with 30–60% OTMs has the potential to replace 100% ITMs for improving antioxidant capacity and nutrient digestibility and for reducing fecal mineral excretion without compromising the performance of growing-finishing pigs.
Taxonomic Description and Complete Genome Sequencing of Pseudomonas silvicola sp. nov. Isolated from Cunninghamia laceolata
Authors: Tian Longyan , Zhang Yanfeng , Yang Hua , Zhao Qian , Qiu Hualong , Xu Jinzhu , Qin Changsheng 
Published: May 2023

The Pseudomonas strain T1-3-2T isolated from the cone of Cunninghamia laceolata exhibited growth-promoting and antifungal activity. Strain T1-3-2T was characterized by a polyphasic taxonomy and complete genome sequencing analysis to explore its taxonomic position and biocontrol potentials fully. The results revealed that strain T1-3-2T shares a high degree of similarity with Pseudomonas eucalypticola and is distinct from any known Pseudomonas species. The G + C content was 61.65%, and the difference was greater than 1 compared to “P. eucalypticola”. Additionally, values of the average nucleotide identity blast (ANIb), average nucleotide identity MUMmer (ANIm), and DNA-DNA hybridization (DDH) between T1-3-2T and its closest known related species, “P. eucalypticola”, were below the thresholds necessary for species delineation. Furthermore, the T1-3-2T strain exhibited the distinctions with the multiple polar flagella and the specific quinone system with MK8 compared with that of “P. eucalypticola”. Collectively, these findings affirm the designation of strain T1-3-2T as a new Pseudomonas species, proposed to be named Pseudomonas silvicola, with T1-3-2T as the type strain. Genomic analyses revealed strain T1-3-2T contains three circular DNA contigs, including a 7,613,303 bp chromosome and two plasmids (952,764 bp and 84,880 bp). Bioinformatics analyses further offered potential insight into the molecular mechanisms whereby this strain can promote plant growth and control disease, revealing encoded genes related to antibiotic and secondary metabolite production, the uptake and biosynthesis of siderophores, and pyoverdine biosynthesis. These genomic data offer a valuable foundation for future efforts to apply the T1-3-2T strain in research contexts.
Assessing the Impact of Roasting Temperatures on Biochemical and Sensory Quality of Macadamia Nuts (Macadamia integrifolia)
Authors: Aruwajoye Noluthando Noxolo , Buthelezi Nana Millicent Duduzile , Mditshwa Asanda , Tesfay Samson Zeray , Magwaza Lembe Samukelo 
Published: May 2023

Depending on the temperature regime used during roasting, the biochemical and sensory characteristics of macadamia nuts can change. ‘A4′ and ‘Beaumont’ were used as model cultivars to examine how roasting temperatures affected the chemical and sensory quality of macadamia nuts. Using a hot air oven dryer, macadamia kernels were roasted at 50, 75, 100, 125, and 150 °C for 15 min. The quantity of phenols, flavonoids, and antioxidants in kernels roasted at 50, 75, and 100 °C was significant (p < 0.001); however, these kernels also had high levels of moisture content, oxidation-sensitive unsaturated fatty acids (UFAs), and peroxide value (PV), and poor sensory quality. Low moisture content, flavonoids, phenols, antioxidants, fatty acid (FA) compositions, high PV, and poor sensory quality—i.e., excessive browning, an exceptionally crunchy texture, and a bitter flavor—were all characteristics of kernels roasted at 150 °C. With a perfect crispy texture, a rich brown color, and a strong nutty flavor, kernels roasted at 125 °C had lower PV; higher oxidation-resistant UFA compositions; considerable concentrations of flavonoids, phenols, and antioxidants; and good sensory quality. Therefore, ‘A4′ and ‘Beaumont’ kernels could be roasted at 125 °C for use in the industry to improve kernel quality and palatability.