bluuebunny/crossref_metadata_2025_split huggingface dataset:
Presence of human adenovirus 36 in visceral fat tissue, viral load, and analysis of its genetic variability
Authors: Sanchez‐Aguillon Fabiola , Alarcon‐Valdes Patricia , Rojano‐Rodriguez Martin , Ibarra‐Arce Aurora , Olivo‐Diaz Angelica , Santillan‐Benitez Jonnathan Guadalupe , Martinez‐Hernandez Fernando , Maravilla Pablo , Romero‐Valdovinos Mirza 
Published: August 2023

AbstractIt has been proposed that infection by adipogenic viruses constitutes a “low risk” factor for obesity. Here, we report the presence of adenovirus 36 (Ad36) and its viral load copy number in fat tissue of participants with obesity and normal weight; phylogenetic analysis was performed to describe their relationship and genetic variability among viral haplotypes. Adipose tissue obtained from 105 adult patients with obesity (cases) and 26 normal‐weight adult participants as controls were analyzed by quantitative polymerase chain reaction (qPCR) amplifying the partial Ad36 E1a gene. The amplicons were examined by melting curves and submitted to sequencing. Then, genetic diversity and phylogenetic inferences were performed. Ad36 was identified at rates of 82% and 46% in the case and control groups, respectively (p = 1.1 × 10−4, odds ratio = 5.28); viral load copies were also significantly different between both groups, being 25% higher in the case group. Melting curve analysis showed clear amplification among positive samples. Phylogenetic inferences and genetic diversity analyses showed that the Ad36 E1a gene exhibits low genetic variability and differentiation with strong gene flow due to an expanding process. Our results suggest that the phenomenon of infectobesity by Ad36 might not be a low‐risk factor, as has been previously argued by other authors.
Patient‐reported outcome tools in musculoskeletal oncology
Authors: Vijayakumar Gayathri , Blank Alan T. 
Published: August 2023

AbstractPatient‐reported outcomes (PRO) are collected directly from the patient and have become increasingly utilized in the clinical setting and in clinical research. In musculoskeletal oncology patients, a number of patient‐reported outcomes measures (PROM) have been developed and investigated to evaluate functional outcomes and health‐related quality of life in these patients. With the growing evidence for PROM in musculoskeletal oncology patients, PROM should be considered for the clinical care of these patients.
Anisotropically weighted Lq$L^q$‐Lr$L^r$ estimates of the Oseen semigroup in exterior domains, with applications to the Navier–Stokes flow past a rigid body
Authors: Takahashi Tomoki 
Published: August 2023

AbstractWe consider the spatial–temporal behavior of the Navier–Stokes flow past a rigid body in . This paper develops analysis in Lebesgue spaces with anisotropic weights , which naturally arise in the asymptotic structure of fluid when the translational velocity of the body is parallel to thex1‐direction. We derive anisotropically weighted ‐ estimates for the Oseen semigroup in exterior domains. As applications of those estimates, we study the stability/attainability of the Navier–Stokes flow in anisotropically weighted spaces to get the spatial–temporal behavior of nonstationary solutions.
Multiband bandpass filter with asymmetric dual‐band response based on metacell
Authors: Hugar Shobha , Baligar Jambunath , Dakulagi Veerendra , Alimovna Pardayeva Zulfizar 
Published: August 2023

AbstractThe impressive growth in present‐day wireless communication systems demands compact, low‐power, cost‐effective, planar multiband microwave devices to increase the speed of communication and reduce hardware requirements, which subsequently reduce the power requirement of the system. Accordingly, this article aims to design a multiband microstrip bandpass filter with asymmetric dual‐band response based on metacell. The proposed filter is designed for wide and narrow dual‐band responses with fractional bandwidths of 72% and 2.6%, respectively. For the first time in this article, a new application of metacell in the design of dual‐band filters is discussed. A folded asymmetric step‐impedance resonator and a novel metacell structure—Dual loop split ring resonators are used to obtain wideband and dual‐band responses, respectively. The proposed work discusses the design methodology, and analysis of metacell structure based on a quasistatic model and compares simulation results with experimental results. The proposed dual‐band filter presents an insertion loss (S21) of less than 1 dB and input reflection coefficient (S11) greater than 10 dB in both passbands centered at 3.3 and 5.7 GHz. The designed filter is suitable for wireless communication applications—Wireless Access in the Vehicular Environment.
Prediction of Hearing Prognosis After Intact Canal Wall Mastoidectomy With Tympanoplasty Using Artificial Intelligence
Authors: Lim Sung Jin , Jeon Eun‑Tae , Baek Namyoung , Chung Young Han , Kim Sang Yeop , Song Insik , Rah Yoon Chan , Oh Kyoung Ho , Choi June 
Published: August 2023

AbstractObjectiveTo evaluate the performance of a machine learning model and the effects of major prognostic factors on hearing outcomes following intact canal wall (ICW) mastoidectomy with tympanoplasty.Study DesignRetrospective cross‐sectional study.SettingTertiary hospital.MethodsA total of 484 patients with chronic otitis media who underwent ICW tympanomastoidectomy between January 2007 and December 2020 were included in this study. Successful hearing outcomes were defined by a postoperative air‐bone gap (ABG) of ≤20 dB and preoperative air conduction (AC)‐postoperative AC value of ≥15 dB according to the Korean Otological Society guidelines for outcome reporting after chronic otitis media surgery. The light gradient boosting machine (LightGBM) and multilayer perceptron (MLP) models were tested as artificial intelligence models and compared using logistic regression. The main outcome assessed was the successful hearing outcome after surgery, measured using the area under the receiver operating characteristic curve (AUROC).ResultsIn the analysis using the postoperative ABG criterion, the LightGBM exhibited a significantly higher AUROC compared to those of the baseline model (mean, 0.811). According to the difference between preoperative and postoperative AC, the MLP showed a significantly higher AUROC than those of the baseline model (mean, 0.795).ConclusionThis study analyzed multiple factors that could affect the hearing outcome using different artificial intelligence models and found that preoperative hearing status was the most important factor. Our findings provide additional information regarding postoperative hearing for clinicians.
Duchenne muscular dystrophy respiratory profiles from real world registry data
Authors: Hnaini Mona , Downs Matt , Miller Michael R. , Campbell Craig , St‐Laurent Aaron 
Published: August 2023

AbstractIntroductionUnderstanding real‐world profiles from neuromuscular databases is helpful for optimizing clinical care and planning research studies. The Canadian Neuromuscular Disease Registry (CNDR) has respiratory data from a population of boys with Duchenne Muscular Dystrophy (DMD).ObjectivesTo describe cross‐sectional respiratory profiles from a national DMD real‐world dataset. To explore the relationship between forced vital capacity percent predicted (FVC%) and disease severity parameters: scoliosis, ambulation and ventilation status.MethodsDescriptive statistics summarized the respiratory profiles. The CNDR registry enrolls and collects DMD clinic data from 36 Canadian centers.ResultsThere were 414 participants enrolled. The age ranged from 2 to 36 years old. Pulmonary function test data were available for 323 participants. The use of ventilatory support was seen in a significant proportion (19.5%) of subjects by age 14–16 years and was used by the majority (69.2%) by age 20–22 years. FVC% declined at a rate of 3.19% per year with every 1‐year increase in age. FVC% declined annually by 2.47% in nonambulatory participants versus by 0.96% in ambulatory participants. FVC% did not significantly change over age with the presence of scoliosis or use of ventilatory technology.ConclusionsThe data from this large cohort are valuable for understanding real‐world patterns of clinical care and disease progression. There is a significant association between the loss of ambulation and the rate of FVC% decline. Further longitudinal studies are needed to better understand the impact of disease parameters on pulmonary function decline and the need for ventilatory support.
Impact of intrinsic and extrinsic risk factors on early‐onset lung disease in cystic fibrosis
Authors: Huang Leslie , Lai HuiChuan J. , Song Jie , Zhao Zijie , Lu Qiongshi , Murali Sangita G. , Brown Donna M. , Worthey Elizabeth A. , Farrell Philip M. 
Published: August 2023

AbstractBackgroundAlthough respiratory pathology is known to develop in young children with cystic fibrosis (CF), the determinants of early‐onset lung disease have not been elucidated.ObjectiveWe aimed to determine the impact of potential intrinsic and extrinsic risk factors during the first 3 years of life, testing the hypothesis that both contribute significantly to early‐onset CF lung disease.DesignWe studied 104 infants born during 2012–2017, diagnosed through newborn screening by age 3 months, and evaluated comprehensively to 36 months of age. Lung disease manifestations were quantified with a new scoring system known as CFELD for Cystic Fibrosis Early‐onset Lung Disease. The variants in the cystic fibrosis transmembrane conductance regulator (CFTR) gene were determined and categorized. Whole genome sequencing was performed on each subject and the data transformed to polygenic risk scores (PRS) that aggregate variants associated with lung function. Extrinsic factors included socioeconomic status (SES) indicators and environmental experiences such as exposures to smoking, pets, and daycare.ResultsWe found by univariate analysis that CFTR genotype and genetic modifiers aggregated by the PRS method were significantly associated with early‐onset CF lung disease. Ordinal logistic regression analysis demonstrated that high and stable SES (maternal education ≥community college, stable 2‐parent home, and not receiving Medicaid) and better growth (weight‐for‐age and height‐for‐age z‐scores) reduced risks, while exposure to smoking and daycare ≥20 h/week increased the risk of CFELD severity.ConclusionsExtrinsic, modifiable determinants are influential early and potentially as important as the intrinsic risk factors in the onset of CF lung disease.
Adaptive sliding mode control for semi‐Markov jump uncertain discrete‐time singular systems
Authors: Zhang Chengcheng , Kao Yonggui , Xie Jing 
Published: August 2023

AbstractThis note is devoted to the analysis of adaptive sliding mode control of H/passivity of semi‐Markov jump discrete‐time uncertain singular systems. We consider the constraints of parameter uncertainties, unknown nonlinear functions, and external disturbances throughout the model. Firstly, a novel mode‐independent sliding mode surface is constructed, then the sliding mode dynamic equation under the equivalent controller is obtained. Secondly, by introducing virtual points, several sufficiency criteria are derived for the sliding mode dynamic ensuring H/passive performance and stochastic admissibility with linear matrix inequalities form. Thirdly, the state trajectory can be driven into a switching band containing the origin by adaptive sliding mode control techniques. Finally, the effectiveness of our findings is demonstrated by comparing existing strategies with three simulation examples.
Research on coupled socio‐ecohydrological systems—implementing a highly integrative and interdisciplinary research agenda in the Doctoral School “Human River Systems in the 21st Century (HR21)”
Authors: Hein Thomas , Auhser Alexander , Byekwaso Flavia , Graf Wolfram , Hoevel Adriane , Schmid Martin , Stockinger Michael , Stumpp Christine , Tschikof Martin , Tuerk Hatice , Weigelhofer Gabriele 
Published: August 2023

AbstractThe access to an adequate quantity and quality of water is vital to sustain healthy ecosystems and human socioeconomic development. However, the shift from an agrarian, solar energy based to an industrialized, fossil fuel‐based socio‐metabolic regime has put natural water resources under stress and led to dramatic transformations of riverine landscapes in the Anthropocene. Thus, we need interdisciplinary research approaches that integrate the knowledge and methods from ecology, humanities, and engineering. The Doctoral School “Human River Systems in the 21st Century” (HR21) studies riverine landscapes as coupled socio‐ecohydrological systems (SEHS) within four research clusters, that is, connectivity, metabolism, vulnerability, and governance. HR21 analyzes the transformation processes and coevolution of nature and society in rivers and their response to future environmental, social, cultural, and economic drivers of change. HR21 aims to improve the understanding of the coupling of the socioeconomic, ecological, and hydrological systems within industrialized riverine landscapes to support their urgent, more sustainable transformation. To discuss how this agenda can be implemented, five different HR21 PhD projects are presented, clearly routed in one scientific domain, applying a combination of the research clusters and addressing various topics: (i) hydropower effects in high alpine river ecosystems, (ii) wastewater impacts on carbon storage and greenhouse gas fluxes in tropical wetlands, (iii) the nutrient retention and ecosystem service potential of floodplains in large river catchments, and the influence of hydrometeorological variables on (iv) the runoff response and on (v) the transit time distribution of runoff, both impacting water resource management at the basin level. These examples highlight how disciplinary PhD research can be framed within an interdisciplinary research agenda to coupled SEHS.
Analyzing the blockades to electric vehicle mobility in an emerging economy: Toward a triple bottom line sustainable development
Authors: Gahlaut Tushar , Dwivedi Gourav , Dwivedi Ashish 
Published: August 2023

AbstractThe emerging economies are moving toward electric vehicles (EVs), which are much sustainable means of transportation. However, many social, economic, and technological blockades of EV mobility remain to be addressed. The study investigates social, economic, and technological blockades for e‐mobility in an emerging economy and simultaneously concentrating on their existing and future business implications. Identification of e‐mobility blockades is obtained through literature review and consensus of the experts. Kappa analysis is used to strain the priority map of the mentioned blockades on the basis of developing consensus among experts. Thereafter, a multi criteria decision making approach that is, best‐worst method is adopted to rank the identified potential blockades. The study models the social, economic, and technological blockades of EV mobility in context of emerging economy. To cater blockades in a desired sequence, the study further suggests the ranking sequence of blockades to enhance e‐mobility toward sustainable development. The findings from the study reveals that “costs associated with EVs and “the lack of government policies, standards, and regulations” are the most important blockades to sustainable EV adoption. Thus, the organizations and the Government need to find ways to reduce the cost of EVs and simultaneously should plan and develop policies to enhance EV adoption and to reduce the usage of gasoline vehicles. The third most important blockade that is, “low demand due to undetermined sustainable benefits” indicates that there is an urgent need to spread awareness among the consumers about the sustainable benefits for the adoption of EVs. Further, the sensitivity analysis reveals that sensitivity range for weightage of the group of academicians lies between 0.3 and 0.7 on a scale of 1. If more weightage is provided to the practical scenario, it is discovered that “location of charging station (BEV4)” is more important than “lack of flexible distribution network (BEV2)” to enhance the amount of EV adoption in India. The study provides insights to practitioners dealing with e‐mobility in emerging economies, showing the appropriate sequence of the blockades to help them build up strategies to mitigate these blockades.
Positron Emission Tomography Studies of the Biodistribution, Translocation, and Fate of Poly Allyl Amine‐Based Carriers for Sirna Delivery by Systemic and Intratumoral Administration
Authors: Simo Cristina , Salvador Cristian , Andreozzi Patrizia , Gomez‐Vallejo Vanessa , Romero Gabriela , Dupin Damien , Llop Jordi , Moya Sergio E. 
Published: August 2023

AbstractPolyamine‐based vectors offer many advantages for gene therapy, but they are hampered by a limited knowledge on their biological fate and efficacy for nucleic acid delivery. The 18F radiolabeled siRNA is complexed with poly(allyl amine) hydrochloride (PAH), PEGylated PAH (PAHPEG), or oleic acid‐modified PAH (PAHOleic) to form polyplexes, and injected them intravenously into healthy rodents. The biodistribution patterns obtained by positron emission tomography (PET) imaging vary according to the polymer used for complexation. Free siRNA is quickly eliminated through the bladder. PAH and oleic acid modify PAH polyplexes accumulate in the lungs and liver. No elimination through the bladder is observed for PAH and PAHOleic within 2 h after administration. PAHPEG polyplexes accumulate in kidneys and are eliminated through the bladder. Polyplexes prepared with 18F‐labeled oleic acid‐modified PAH and non‐labeled siRNA show similar biodistribution to those prepared with labeled siRNA, but with more accumulation in the lungs due to the presence of non‐complexed polymer. Intravenous administration of PAHOleic polyplexes in tumor models results in a limited availability of siRNA. When PAHOleic polyplexes are administered intratumorally in tumor bearing rodents, ≈40% of the radioactivity is retained in the tumor after 180 min while free siRNA is completely eliminated.
MDBs Versus MIBs in Case of Multiple Hypotheses: A Study in Context of Deformation Analysis
Authors: Zaminpardaz Safoora , Teunissen Peter J. G. 
Published: August 2023

AbstractStatistical testing procedures employed in geodetic quality control often consist of two steps: detection and identification. In the detection step, the null hypothesis (working model)
$$\mathcal {H}_0$$

ℋ

0

undergoes a validity check. If the outcome of the detection step is the rejection of
$$\mathcal {H}_0$$

ℋ

0

, identification of potential source of model error is exercised through a search among the specified alternative hypotheses. The testing performance is thus not only led by its ability to detect biases but to correctly identify them as well. The detection capability of a testing regime is usually assessed by its Minimal Detectable Bias (MDB) given a certain correct detection probability. The information provided by the MDB only concerns correct detection and not correct identification. The testing identification performance should be evaluated by its Minimal Identifiable Bias (MIB) given a certain correct identification probability. In this contribution, we demonstrate the difference between MDB and MIB. It is hereby highlighted that a small MDB (or a high probability of correct detection) does not necessarily imply a small MIB (or a high probability of correct identification). The factors driving the difference between detection and identification performance are illustrated using a simple example. Our analysis is then continued in the framework of deformation monitoring.
Near-infrared indocyanine green fluorescent cholangiography in urgent and emergency laparoscopic cholecystectomy: a preliminary study after propensity score-matched study
Authors: Losurdo Pasquale , Giunta Carlotta , Modica Anna , de Manzini Nicolò , Bortul Marina 
Published: August 2023

Abstract
Introduction
Bile duct injury is a major complication of laparoscopic cholecystectomy (LC). Indocyanine green near-infrared fluorescence cholangiography (ICG-NIFC) is a well-recognized technique who provides an intraoperative mapping of the biliary system.

Methods
All patients underwent urgent LC and randomly divided into two groups: in one group, only white light imaging was used and, in the ICG group, ICG was used. Due to the heterogeneity of our groups, a PSM was performed with a 1:1 PSM cohort.

Results
The use of ICG clearly decreases the operation time (p value 0.002). The overall rate of intra- and post- operative complications was 4.17% and 15.8% respectively. Post-operative biliary duct injury trend decreases in ICG group and after the homogenization of the 2 cohorts, the intra- and post- operative complications (including vascular and biliary duct injury) results changed with a highest rate of complication in the cohort with no-ICG administration.
The use of NIFC demonstrated a protective effect against intra- and post- operative complications and biliary duct injury (HR 0.037, p value 0.337 and HR 0.039, p value 0.647; HR 0.288; p value 0.05 and HR 0.635; p value 0.687, respectively).

Conclusions
The intra-operative use of NIFC showed a trend in the reduction of the rate of intra- and post-operative complications, the duration of surgery, and the length of hospital stay. ICG is a highly safe approach to urgent and emergency LC, as for elective LC, and could lead the surgeon to conduct the procedure more efficiently.
Asymptotic isoperimetry on non collapsed spaces with lower Ricci bounds
Authors: Antonelli Gioacchino , Pasqualetto Enrico , Pozzetta Marco , Semola Daniele 
Published: August 2023

AbstractThis paper studies sharp and rigid isoperimetric comparison theorems and asymptotic isoperimetric properties for small and large volumes on N-dimensional $$\textrm{RCD}(K,N)$$

RCD
(
K
,
N
)

spaces $$(X,\textsf {d},\mathscr {H}^N)$$

(
X
,
d
,

H
N

)

. Moreover, we obtain almost regularity theorems formulated in terms of the isoperimetric profile and enhanced consequences at the level of several functional inequalities. Most of our statements seem to be new even in the classical setting of smooth, non compact manifolds with lower Ricci curvature bounds. The synthetic theory plays a key role via compactness and stability arguments.
Classification of anisotropic Triebel-Lizorkin spaces
Authors: Koppensteiner Sarah , van Velthoven Jordy Timo , Voigtlaender Felix 
Published: August 2023

AbstractThis paper provides a characterization of expansive matrices $$A \in \textrm{GL}(d, {\mathbb {R}})$$

A
∈
GL
(
d
,
R
)

generating the same anisotropic homogeneous Triebel–Lizorkin space $$\dot{\textbf{F}}^{\alpha }_{p,q}(A)$$

F
˙

p
,
q

α

(
A
)

for $$\alpha \in {\mathbb {R}}$$

α
∈
R

and $$p,q \in (0,\infty ]$$

p
,
q
∈
(
0
,
∞
]

. It is shown that $$\dot{\textbf{F}}^{\alpha }_{p,q}(A) = \dot{\textbf{F}}^{\alpha }_{p,q}(B)$$

F
˙

p
,
q

α

(
A
)

=

F
˙

p
,
q

α

(
B
)

if and only if the homogeneous quasi-norms $$\rho _A, \rho _B$$

ρ
A

,

ρ
B

associated to the matrices A, B are equivalent, except for the case $$\dot{\textbf{F}}^0_{p, 2} = L^p$$

F
˙

p
,
2

0

=

L
p

with $$p \in (1,\infty )$$

p
∈
(
1
,
∞
)

. The obtained results complement and extend the classification of anisotropic Hardy spaces $$H^p(A) = \dot{\textbf{F}}^{0}_{p,2}(A)$$

H
p

(
A
)

=

F
˙

p
,
2

0

(
A
)

, $$p \in (0,1]$$

p
∈
(
0
,
1
]

, in Bownik (Mem Am Math Soc 164(781):vi+122, 2003).