bluuebunny/crossref_metadata_2025_split huggingface dataset:
Barriers and enablers of vigorous intermittent lifestyle physical activity (VILPA) in physically inactive adults: a focus group study
Authors: Thøgersen-Ntoumani C. , Kritz M. , Grunseit A. , Chau J. , Ahmadi M. , Holtermann A. , Koster A. , Tudor-Locke C. , Johnson N. , Sherrington C. , Paudel S. , Maher C. , Stamatakis E. 
Published: July 2023

Abstract
Background
Vigorous Intermittent Lifestyle Physical Activity (VILPA) refers to brief bouts of vigorous intensity physical activity performed as part of daily living. VILPA has been proposed as a novel concept to expand physical activity options among the least active. As a nascent area of research, factors which impede or encourage VILPA in physically inactive adults are yet to be explored. Such information is pertinent in the design of future interventions. We examined the barriers and enablers of VILPA among physically inactive adults using the Capability, Opportunity, Motivation, Behavior (COM-B) model as a conceptual framework.

Methods
We recruited a sample of self-identified physically inactive middle-aged and older adults (N = 78) based in Australia to take part in 19 online focus groups across three age groups: young-middle (age 35–44), middle (age 45–59) and old (age 60–76). We analyzed interviews using a critical realist approach to thematic analysis. Identified barriers and enablers were subsequently mapped onto the COM-B model components.

Results
The data generated 6 barriers and 10 enablers of VILPA that corresponded to COM-B concepts. Barriers included physical limitations (physical capability), perceptions of aging, need for knowledge (psychological capability), environmental constraints (physical opportunity), perceptions of effort and energy, and fear (automatic motivation). Enablers included convenience, reframing physical activity as purposeful movement, use of prompts and reminders (physical opportunity), normalization of taking the active option, gamification (social opportunity), sense of achievement, health improvements, personally salient rewards (reflective motivation), identity fit, and changing from effortful deliberation to habitual action (automatic motivation).

Conclusion
The barriers and enablers of VILPA span capability, opportunity, and motivation beliefs. Promoting the time-efficient nature and simplicity of VILPA requiring no equipment or special gym sessions, the use of prompts and reminders at opportune times, and habit formation strategies could capitalize on the enablers. Addressing the suitability of the small bouts, the development of specific guidelines, addressing safety concerns, and explicating the potential benefits of, and opportunities to do, VILPA could ameliorate some of the barriers identified. Future VILPA interventions may require limited age customization, speaking to the potential for such interventions to be delivered at scale.
Real-world outcomes of PD-L1 inhibitors combined with thoracic radiotherapy in the first-line treatment of extensive stage small cell lung cancer
Authors: Peng Jianfeng , Zhang Lemeng , Wang Liping , Feng Hui , Yao Dongmei , Meng Rui , Liu Xiaomei , Li Xiaohua , Liu Ningbo , Tan Bingxu , Huang Zhaoqin , Li Shanshan , Meng Xiangjiao 
Published: July 2023

Abstract
Background
The CREST study showed that the addition of thoracic radiotherapy (TRT) could improve the survival rate in patients with extensive stage small cell lung cancer (ES-SCLC), but whether TRT can bring survival benefit in the era of immunotherapy remains controversial. This study aimed to explore the efficacy and safety of adding TRT to the combination of PD-L1 inhibitors and chemotherapy.

Methods
The patients who received durvalumab or atezolizumab combined with chemotherapy as the first-line treatment of ES-SCLC from January 2019 to December 2021 were enrolled. They were divided into two groups, based on whether they received TRT or not. Propensity score matching (PSM) with a 1:1 ratio was performed. The primary endpoints were progression-free survival (PFS), overall survival (OS) and safety.

Results
A total of 211 patients with ES-SCLC were enrolled, of whom 70 (33.2%) patients received standard therapy plus TRT as first-line treatment, and 141 (66.8%) patients in the control group received PD-L1 inhibitors plus chemotherapy. After PSM, a total of 57 pairs of patients were enrolled in the analysis. In all patients, the median PFS (mPFS) in the TRT and non-TRT group was 9.5 and 7.2 months, respectively, with HR = 0.59 (95%CI 0.39–0.88, p = 0.009). The median OS (mOS) in the TRT group was also significantly longer than that in the non-TRT group (24.1 months vs. 18.5 months, HR = 0.53, 95%CI 0.31–0.89, p = 0.016). Multivariable analysis showed that baseline liver metastasis and the number of metastases ≥ 3 were independent prognostic factors for OS. Addition of TRT increased the incidence of treatment-related pneumonia (p = 0.018), most of which were grade 1–2.

Conclusions
Addition of TRT to durvalumab or atezolizumab plus chemotherapy significantly improves survival in ES-SCLC. Although it may leads to increased incidence of treatment-related pneumonia, a majority of the cases can be relieved after symptomatic treatment.
Factors influencing junior high school students’ perceptions of attending school in Japan
Authors: Nakamura-Thomas Hiromi , Sano Nobuyuki , Maciver Donald 
Published: July 2023

Abstract
Background
School attendance is a crucial determinant of academic success. Our previous research has identified factors that influence elementary school students’ perceptions of attending school, but whether these factors apply to older students remains unclear. We investigated the extent to which the factors identified in the previous research apply to junior high school students and their attitudes toward attending school.

Methods
We hypothesized that students’ “perceptions of attending school” was directly influenced by their perceptions of “relationships with friends and teachers,” “current circumstances,” “subjective health status,” and “having people to share experiences and thoughts with.” We developed an original questionnaire with 19 items and analyzed data collected from 6245 junior high school students in Japan, using a structural equation model.

Results
The final model demonstrated a good fit. Students’ “positive perceptions of attending school” was directly and positively influenced by their “positive perceptions of relationships with friends and teachers” and directly and negatively influenced by their “perceptions of poorer subjective health status”. Other latent variables directly and positively influenced the perceptions of attending school, but not strongly. Students’ perceptions of “relationships with friends and teachers,” “current circumstances,” and “having people to share experiences and thoughts with” correlated positively with each other. These three latent variables also correlated negatively with “poorer subjective health status.”

Conclusions
The role of positive relationships with friends and teachers in shaping students' perceptions of school attendance, coupled with the negative impact of poorer subjective health status, underscores the need for educators to adopt approaches that specifically address these areas. It is crucial to provide support to students in cultivating positive relationships, fostering positive perceptions of school, and offering resources to those who are encountering mental or physical health challenges. Implementing the evidence-based questionnaire developed in this study is recommended to enhance student support and well-being.
Community-based lifestyle intervention for diabetes (Co-LID study) management in rural Nepal: study protocol for a clustered randomized controlled trial
Authors: Rawal Lal , Dahal Padam , Paudel Grish , Biswas Tuhin , Shrestha Rabina , Makaju Deepa , Shrestha Abha , Yadav Uday , Sahle Berhe W , Iwashita Hanako , Masuda Gaku , Renzaho Andre , Shakya Prabin , Shrestha Archana , Karmacharya Biraj , Sakamoto Haruka , Koju Rajendra , Sugishita Tomohiko 
Published: July 2023

Abstract
Background
Type 2 diabetes mellitus (T2DM) has increased globally; with a disproportionate burden in South and Southeast Asian countries, including Nepal. There is an urgent need for clinically and cost-effective culturally adapted T2DM management programs. In this study, we aim to assess the effectiveness of community based culturally appropriate lifestyle intervention in improving the management and care of people with T2DM.

Methods
We will conduct a cluster randomized control trial to evaluate the effectiveness of community based culturally appropriate lifestyle intervention in improving T2DM outcomes. The trial will be conducted in 30 randomly selected healthcare facilities from two purposively selected districts (Kavrepalanchowk and Nuwakot districts) of Bagmati province, Nepal. The selected healthcare facilities are being randomized into 15 interventions (n = 15) and usual care (n = 15) groups. Those in the intervention will receive group-based 12 an hour-long fortnightly session delivered over 6 months period. The intervention package includes 12 planned modules related to diabetes care, ongoing support, supervision and monitoring, follow-up from the trained community health workers, and educational materials on diabetes self-management. The participants in the usual care groups will receive pictorial brochure on diabetes management and they will continue receiving the usual care available from the local health facilities. The primary outcome is HbA1c level, and the secondary outcomes include quality of life, health care utilization, and practice of self-care behaviour, depression, oral health quality of life, and economic assessment of the intervention. Two points measurements will be collected by the trained research assistants at baseline and at the end of the intervention.

Discussion
This study will provide tested approaches for culturally adapting T2DM interventions in the Nepalese context. The findings will also have practice and policy implications for T2DM prevention and management in Nepal.

Trial registration
Australia and New Zealand Clinical Trial Registry (ACTRN12621000531819). Registered on May 6, 2021.
TB-IECS: an accurate machine learning-based scoring function for virtual screening
Authors: Zhang Xujun , Shen Chao , Jiang Dejun , Zhang Jintu , Ye Qing , Xu Lei , Hou Tingjun , Pan Peichen , Kang Yu 
Published: July 2023

AbstractMachine learning-based scoring functions (MLSFs) have shown potential for improving virtual screening capabilities over classical scoring functions (SFs). Due to the high computational cost in the process of feature generation, the numbers of descriptors used in MLSFs and the characterization of protein–ligand interactions are always limited, which may affect the overall accuracy and efficiency. Here, we propose a new SF called TB-IECS (theory-based interaction energy component score), which combines energy terms from Smina and NNScore version 2, and utilizes the eXtreme Gradient Boosting (XGBoost) algorithm for model training. In this study, the energy terms decomposed from 15 traditional SFs were firstly categorized based on their formulas and physicochemical principles, and 324 feature combinations were generated accordingly. Five best feature combinations were selected for further evaluation of the model performance in regard to the selection of feature vectors with various length, interaction types and ML algorithms. The virtual screening power of TB-IECS was assessed on the datasets of DUD-E and LIT-PCBA, as well as seven target-specific datasets from the ChemDiv database. The results showed that TB-IECS outperformed classical SFs including Glide SP and Dock, and effectively balanced the efficiency and accuracy for practical virtual screening.
A variable step size least mean p-power adaptive filtering algorithm based on multi-moment error fusion
Authors: Zhu Boyu , Wang Biao , Cai Banggui , Zhu Yunan , Chao Peng , Fang Zide 
Published: July 2023

AbstractFor the channel estimation problem under α-stable distributed impulse interference, the traditional fixed-step adaptive filtering cannot satisfy the fast convergence speed and low steady-state error at the same time, whereas the variable-step method is able to effectively solve this contradiction. This paper proposes an improved variable step-size least mean p-power adaptive algorithm that offers good robustness against impulsive noise. The proposed algorithm takes into account the linkage between the errors and uses the adjustment of the step size based on the errors of the current moment and the previous k moments, thus overcoming the problems of poor anti-noise performance and large steady-state fluctuations of the fixed-step size algorithm. This algorithm ensures that the step size does not change abruptly when the system is disturbed by impulse noise and can achieve a lower steady-state error. The simulation results show that the algorithm has better convergence than the traditional fixed step-size algorithm and the existing variable step-size algorithm under the interference of impulsive noise.
Changes in movement, habitat use, and response to human disturbance accompany parturition events in bighorn sheep (Ovis canadensis)
Authors: Brushett Aidan , Whittington Jesse , Macbeth Bryan , Fryxell John M. 
Published: July 2023

AbstractParturition and the early neonatal period are critical life history stages in ungulates with considerable implications for population growth and persistence. Understanding the changes in behaviour induced by ungulate parturition is important for supporting effective population management, but reliably identifying birth sites and dates presents a challenge for managers. Rocky Mountain bighorn sheep (Ovis canadensis canadensis) are one such highly valued and ecologically important species in montane and subalpine ecosystems of Western North America. In the face of changing patterns of anthropogenic land use, wildlife managers increasingly require site-specific knowledge of the movement and habitat selection characteristics of periparturient sheep to better inform land use planning initiatives and ensure adequate protections for lambing habitat. We used movement data from GPS collared parturient (n = 13) and non-parturient (n = 8) bighorn sheep in Banff National Park, Canada to (1) identify lambing events based on changes in key movement metrics, and (2) investigate how resource selection and responses to human use change during the periparturient period. We fit a hidden Markov model (HMM) to a multivariate characterization of sheep movement (step length, daily home range area, residence time) to predict realistic lambing dates for the animals in our study system. Leave-one-out cross validation of our model resulted in a 93% success rate for parturient females. Our model, which we parameterized using data from known parturient females, also predicted lambing events in 25% of known non-parturient ewes in a test dataset. Using a latent selection difference function and resource selection functions, we tested for postpartum changes in habitat use, as well as seasonal differences in habitat selection. Immediately following lambing, ewes preferentially selected high-elevation sites on solar aspects that were more rugged, closer to escape terrain, and further from roads. Within-home range habitat selection was similar between individuals in different reproductive states, but parturient ewes had stronger selection for low snow depth, sites closer to barren ground, and sites further from trails. We propose that movement-based approaches such as HMMs are a valuable tool for identifying critical parturition habitat in species with complex movement patterns and may have particular utility in study areas without access to extensive field observations or vaginal implant transmitters. Furthermore, our results suggest that managers should minimize human disturbance in lambing areas to avoid interfering with maternal behaviour and ensure access to a broad range of suitable habitat in the periparturient period.
The epidemiology of firework-related injuries in the US, 2012–2022
Authors: Winicki Nolan M. , Waldrop Ian , Orozco Jesus V. , Novak Daniel , Sheets Nicholas W. 
Published: July 2023

Abstract
Background
This study aimed to examine the epidemiology of firework-related injuries within a national population between 2012 and 2022, including the severity of injury by year, patient demographics, body region injured, firework type, and diagnosis category of injury.

Methods
Data were collected from the Consumer Product Safety Commission’s National Electronic Injury Surveillance System, which is a representative nationwide database that collects data on consumer product-related injuries occurring in the US. Injury rates were calculated based on patient age, sex, body region injured, firework type, and diagnosis category.

Results
A total of 3219 injuries, representing an estimated 122,912 firework-related injuries, were treated in emergency departments within the US from 2012 to 2022. The overall incidence rate of firework-related injuries in the study rose by over 17% from 2012 [2.61 cases per 100,000 people (95% CI 2.03–3.20)] to 2022 and [3.05 cases per 100,000 people (95% CI 2.29–3.80)]. The rate of injuries was highest in adolescents and young adults (age 20–24; 7.13 cases per 100,000 people). Men experienced firework injuries at more than double the rate of women (4.90 versus 2.25 cases per 100,000 people). The upper extremities (41.62%), head/neck (36.40%), and lower extremities (13.78%) were the most commonly injured regions. Over 20% of cases in patients older than 20 were significant injuries requiring hospitalization. Aerial devices (32.11%) and illegal fireworks (21.05%) caused the highest rates of significant injury of any firework type.

Conclusions
The incidence of firework-related injuries has risen over the past decade. Injuries remain the most common among adolescents and young adults. In addition, significant injuries requiring hospitalization occur most often during aerial and illegal firework use. Further targeted sale restrictions, distribution, and manufacturing regulations for high-risk fireworks are required to reduce the incidence of significant injury.
The development of dress forms in standing and sitting postures using 3D body scanning and printing
Authors: Yu Minji , Kim Dong-Eun 
Published: July 2023

Abstract3D body scanning and printing are attracting attention as innovative technologies for producing dress forms. While designing dress forms, the shape of the human body must be accurately reflected in the different postures. This study explored the development of dress forms as a tool to understand changes in body size and shape according to postures and reflect this information to design and fit evaluation in the apparel industry. The holistic development process of dress forms in standing and sitting postures was suggested for representing the body shape of a specific target group. The average shape of middle-aged Korean women was derived by analyzing the 6th Size Korea data. A representative participant whose dimensions were closest to the average size was selected among recruited participants for the dress form development. The body data were acquired with a portable 3D scanner and corresponding dress forms and accessories were modeled using 3D CAD software. The models were inspected and corrected through prototyping. Full-size dress forms in standing and sitting postures were printed using a fused deposition modeling (FDM) 3D printer and post-processed. Completed dress forms were body-scanned and their accuracy was evaluated through morphological similarity comparison, cross-sectional image comparison, surface area and volume comparison, and mesh deviation analysis. Although there were some minor differences caused by the modeling process, the developed dress forms reflected the main characteristics and shapes of the representative body satisfactorily.
Evaluating the feasibility of prolonged-release buprenorphine formulations as an alternative to daily opioid agonist therapy regardless of prior treatment adherence: a pilot study
Authors: Hard Bernadette , DeSilva Mohan 
Published: July 2023

Abstract
Background
Effective opioid agonist therapy (OAT) depends on good patient adherence. However, the daily, supervised administration of standard OAT represents a significant burden to patients and often drives poor adherence. Prolonged-release buprenorphine (PRB) formulations may mitigate some of this burden, enabling clinic visits to be substantially reduced. For treatment guidelines to be effective, the likely benefit of a transition to PRB therapy in different patient populations must be established.

Methods
The aim was to determine the feasibility of assessing PRB as an alternative to daily OAT in two groups: those currently adhering well to daily OAT (group 1, N = 5) and those not currently showing adherence or a positive response to daily OAT (group 2, N = 10). This open-label, prospective, non-controlled pilot study was conducted at the Kaleidoscope Drug Project in South Wales, UK. Participants were assessed for history, drug use, psychosocial assessment scores, and clinical severity at baseline and after 6 months of treatment. Primary outcomes were the feasibility of assessing PRB as an alternative to daily OAT and the acceptability of PRB therapy in each group. Secondary outcomes were treatment response, on-top drug use, psychosocial measures, and assessment of clinical severity.

Results
Participants from both groups demonstrated high levels of participation with assessment protocols at both baseline and 6-month follow-up, indicating study feasibility. PRB treatment was acceptable to the majority of participants, with all of group 1 and 70% of group 2 adhering to PRB therapy for the duration of the study and opting to persist with PRB therapy over other OAT options after study completion. All participants who remained on treatment demonstrated marked improvements in psychosocial and clinical severity assessment scores, with some returning to employment or education. On-top drug use remained absent in group 1 and was reduced in group 2.

Conclusions
Evaluation of transition of participants from daily OAT to PRB therapy was shown to be feasible, acceptable, and effective across both groups. A larger randomised controlled trial is warranted, particularly to assess PRB therapy in participants with a history of poor treatment engagement, as the need for therapy is greater in this group and their management is associated with higher costs of care.