bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diagnosis of Leptomeningeal Disease in Diffuse Midline Gliomas by Detection of H3F3A K27M Mutation in Circulating Tumor DNA of Cerebrospinal Fluid
Authors: Shibuma Satoshi , On Jotaro , Natsumeda Manabu , Koyama Akihide , Takahashi Haruhiko , Watanabe Jun , Mitobe Masaki , Nakata Satoshi , Tanaka Yuki , Tsukamoto Yoshihiro , Okada Masayasu , Yoshimura Junichi , Tada Mari , Shimizu Hiroshi , Oya Soichi , Murai Junko , Okamoto Kouichirou , Kawashima Hiroyuki , Kakita Akiyoshi , Oishi Makoto 
Published: January 2025

ABSTRACTIntroductionLeptomeningeal disease (LMD) in diffuse midline gliomas (DMGs) can lead to devastating symptoms such as severe pain, urinary incontinence, and tetraparesis, with limited treatment options. We determined whether detecting H3F3A K27M‐mutant droplets in cerebrospinal fluid (CSF) circulating tumor deoxyribonucleic acid (ctDNA) could be a biomarker for detecting LMD in DMGs.MethodsTwenty‐five CSF samples were obtained from 22 DMG patients. Histological confirmation of H3F3A K27M mutation was obtained in 10 (45.5%) cases. ctDNA was extracted from CSF, and H3F3A K27M‐mutant and wildtype droplets were detected using digital droplet polymerase chain reaction (ddPCR). LMD was diagnosed by CSF cytology and pre‐ and post‐contrast head and spine magnetic resonance (MR) imaging.ResultsThe number of H3F3A K27M‐mutant droplets (median 27 [range: 1–379] vs. median 0 [range: 0–1]; p < 0.0001) and variant allele frequency (VAF) (median 48.9% [range: 7.5%–87.5%] vs. median 0.0% [range: 0.0%–50.0%]; p < 0.0001) were significantly higher in the LMD/early‐LMD group compared to no‐LMD group. In two cases (Cases 4 and 11) without clinical evidence of LMD, multiple H3F3A K27M‐mutant droplets were detected in CSF ctDNA. In those cases, extensive spinal dissemination was detected 6 months after the initial liquid biopsy. One case (Case 15) with high Schlafen11 (SLFN11) expression responded well to treatment for LMD and survived for 532 days after the diagnosis of LMD.ConclusionThis study provides evidence that detecting H3F3A K27M‐mutant droplets in CSF ctDNA is diagnostic for LMD and is more sensitive than traditional methods such as CSF cytology and MR imaging.
Characterization of Potassium Titanate Whisker and UHMWPE‐reinforced Polyethersulfone/Short Carbon Fiber composites: Mechanical, thermal, and structural insights
Authors: Bettegowda Harshavardhan , Mahesh Vishwas , Mahesh Vinyas , Dixit Arun C. 
Published: January 2025

AbstractThermoplastics and their composites have advanced significantly, with ongoing efforts to meet complex engineering demands. This study focuses on polyethersulfone (PES) composites reinforced with 25 wt.% short carbon fibers (SCF), investigating the effects of potassium titanate whiskers (PTW) and ultra‐high‐molecular‐weight polyethylene (UHMWPE) fillers on their properties. Using extrusion and injection molding, PES/SCF composites were developed and modified with 2.5 and 5 wt.% of PTW and UHMWPE fillers. Mechanical tests, including tensile, flexural, and impact assessments, were conducted per ASTM standards. The addition of 25 wt.% SCF improved tensile strength (62.28 MPa) and flexural strength (55.4 MPa), though it decreased notched impact strength (nIS) to 2.1 kJ/m2. Incorporating 5 wt.% PTW further enhanced flexural strength (25 MPa) and marginally increased tensile strength (3.61 MPa) but reduced nIS by 0.7 kJ/m2. Conversely, 5 wt.% UHMWPE decreased tensile and flexural strengths by 12.07 and 3.4 MPa, respectively, while improving nIS by 1.2 kJ/m2. These results suggest that PES/SCF composites tailored with PTW and UHMWPE fillers offer promising potential for secondary structural applications in aerospace and automotive industries, where strength and impact resistance are critical.Highlights
PTW and UHMWPE fillers enhance mechanical properties, elevating PES/SCF composite performance for structural use.
Thermal analysis (TGA, DSC) confirms increased high‐temperature resilience.
SEM imaging shows uniform PTW and UHMWPE distribution, enhancing load transfer and fracture resistance.
Higher storage modulus and lower damping indicate enhanced stiffness, durability, and energy dissipation.
Effect of stacking sequence on the double‐point low velocity impact response and compression‐after‐impact behavior of glass fiber‐reinforced composite laminates
Authors: Li Hao , Liu Kun , Tao Zhen , Yu Zhaogang , Ye Liqing , Xiao Wenkang 
Published: January 2025

AbstractThe double‐point low velocity impact response and compression‐after‐impact behavior of composites were explored in terms of the influence of lay‐up sequences in this paper. Three representative laminates, [0°2/90°2]s cross‐ply, [±45°]2s angle‐ply and [0°/−45°/45°/90°]s quasi‐isotropic laminates were studied. Each laminate was impacted at two points with the same distance from the center sequentially. The force‐time/displacement and energy‐time histories were compared according to the various damage modes induced in the laminates at four different impact distances. The changes of the mechanical features including peak force, maximum displacement and absorbed energy were further analyzed. Results showed that the impact responses and damage characteristics were affected by the stacking sequence and impact distance. The differences of the impact mechanical characteristics decreased with the impact distance increasing because of the reduction of damage interference between the two impacts. The [±45°]2s laminate possessed the best impact resistance compared to the [0°2/90°2]s and [0°/−45°/45°/90°]s laminates. Furthermore, the compressive load–displacement response and the residual strength of the three kinds of laminates were compared. The compressive failure mode was analyzed by the damage morphology and strain history. It was found that the [±45°]2s laminates retained the highest CAI strength. A brittle compressive failure behavior was observed for the [0°2/90°2]s and [0°/−45°/45°/90°]s laminates. However, the compressive failure behavior for the angle‐ply laminates changed from plastic failure to brittle failure with the impact distance increasing.Highlights
The double‐point impact behavior is affected by the stacking sequence.
The [±45°]2s angle‐ply laminate has the best resistance to impact.
The changes of impact responses decrease as the impact distance increases.
The CAI strength decreases with the impact distance increasing.
The angle‐ply laminate shows a plastic failure behavior at low impact distances.
Registration of ‘Yukon Gold’ yellow bean
Authors: Awale Halima E. , Wright Evan M. , Kelly James D. , Bales Scott 
Published: January 2025

Abstract‘Yukon Gold’ (Reg. no. CV‐363, PI 706256) yellow bean (Phaseolus vulgaris L.), developed by Michigan State University AgBioResearch was released in 2024 as an upright, determinate, bush type, mid‐season cultivar with a bright yellow seedcoat. Yukon Gold was developed using the pedigree breeding method to F4 generation followed by pure line selection for disease, agronomic, and quality traits. In 4 year of field trials, Yukon Gold yielded 3116 kg ha−1, flowered in 43 days, and matured in 96 days on average. Plants averaged 38.9 cm in height, with a lodging resistance score of 1.8 and seed weight of 43.1 g 100 seed−1. Yukon Gold is well adapted to growing conditions in Michigan and produces seeds with an intense yellow seedcoat color (highlighter color), which is brighter than others yellow bean cultivars. Yukon Gold is resistant to lodging and possesses a determinate upright growth habit with tolerance to white mold. Yukon Gold is resistant to Bean common mosaic virus, is susceptible to anthracnose race 7 and common bacterial blight. Yukon Gold cooks in 31 min and produces excellent seed color that exceeds industry standards for the yellow bean market class.
Throttleable Solid Propellants Through Embedded Shape Memory Alloy and Resistance Wires
Authors: Messer Derek K. , Nunes Cohen T. , Örnek Metin , Son Steven F. 
Published: January 2025

ABSTRACTSolid propellants are used in propulsion systems for their high performance, feasibility to manufacture, long shelf life, and ease of storage and handling; however, they are limited by the inability to actively control the burning rate. The overall burning rate of solid propellant is predetermined based on geometry (surface area) and operating conditions such as initial temperature and pressure. In this article, we propose two methods to tailor the rate of pressurization (dP/dt) of solid composite ammonium perchlorate/hydroxyl‐terminated polybutadiene (AP/HTPB) propellants using embedded shape memory alloy (SMA) and Nichrome wires through Ohmic heating. First, Nitinol wires, coiled into a spring, are demonstrated to increase the burning surface area upon expanding inside of the solid propellant. The result of this geometry modification was shown to increase the dP/dt by over 180%, thereby throttling the propellant sample. Second, Nichrome wire was embedded in the samples to demonstrate that varying the heat flux (between 24.4 and 153.6 kW/m2) also affects the rate of pressurization under heated conditions. Preheating the solid propellant in this manner increased the rate of pressurization from 69 to 110 MPa/s. This concept is useful for many applications such as in electro‐explosive devices (EEDs) or actuators where it is desired to have the resulting gas expansion rate tailored.
Professional Vision of Preservice and In‐Service Biology Teachers: Tacit Knowledge About Teaching and Learning in Relation to Student Conceptions in Evolution Lessons
Authors: Steinwachs Jens , Martens Helge 
Published: January 2025

ABSTRACTAddressing student conceptions is crucial in science education. Therefore, teachers should be able to notice and interpret situations, in which student conceptions are part of the complex classroom interactions. This study analyzes the skills known as professional vision using an interpretivist research paradigm and a sociocultural perspective. The central concern of this article is to describe the tacit knowledge about teaching and learning that frames and guides the professional vision of preservice and in‐service biology teachers. To collect data, a video clip was used as a stimulus for 31 group discussions and 9 individual interviews with a total of 115 preservice and in‐service biology teachers. The video clip showed classroom interactions between the teacher and students, specifically addressing student conceptions in evolution classes. From 40 available cases, a subsample of 15 contrasting ones was used for in‐depth interpretation and typification. The comparative analyses reveal that these cases share a common feature: professional vision is carried out in an evaluative mode, with participants assessing the teacher's actions and the students' learning outcomes. In their evaluations, the four reconstructed types expressed type‐specific tacit knowledge about teaching and learning. For example, they differ in their conceptualizations of teaching, which form the basis of the evaluation: (1) direct transmission of scientific norms, (2) establishing and facilitating access to scientific norms, (3) interaction that considers individual learners' point of view, and (4) contingent mediation between student conceptions and scientific norms. In the discussion, the results are related to learning theories and strategies for teaching the theory of evolution to develop suggestions for teacher education and professional development.
Thermal Methanol Synthesis from CO2 Using Cu/ZnO Catalysts: Insights from First‐Principles Calculations
Authors: Xi Cong , Nie Yixin , Wang Hongjuan , Dong Cunku , Han Jiuhui , Du Xi‐Wen 
Published: January 2025

Catalytic hydrogenation of carbon dioxide to methanol offers a promising avenue for recycling CO2, enhancing environmental sustainability. Cu/ZnO has long been identified as one of the most effective heterogeneous catalysts for this reaction, yet the detailed understanding of its reaction mechanism and active sites remains incomplete. Recent advances have highlighted the critical role of defects, such as ZnCu steps and stacking faults on Cu surfaces, in enhancing catalyst performance. Here this concept is explored through first‐principles surface simulations of six models, featuring diverse Cu–Zn combinations and specific coordination environments under realistic conditions. It is revealed that Cu/ZnO catalysts with kink defects, rather than surface ZnCu alloys, exhibit optimal activity for methanol synthesis. Specifically, the findings demonstrate how intermediate configurations and rate‐determining steps vary with changes in surface structure and reveal the role of the kink in promoting CO2 reduction to methanol through electronic structure calculation. Moreover, it is found that the predominant synthetic pathway for CH3OH from CO2 involves the reverse water gas shift and CO hydrogenation, rather than the formate route, on Cu/ZnO surfaces with kinks.
The Multifunctional Role of Templates in Chemically Fueled Dynamic Combinatorial Libraries
Authors: Kriebisch Christine M. E. , Kriebisch Brigitte A. K. , Langlais Juliette , Maier Anton S. , Rieger Bernhard , Braun Dieter , Boekhoven Job 
Published: January 2025

AbstractRNA is an information‐carrying molecule that instructs protein synthesis, but it also functions as a catalyst in so‐called ribozymes. Here, we study this multifunctional character using a dynamic combinatorial library powered by chemical fuel. On the one hand, we demonstrate that RNA templates the oligomerization and inhibits deoligomerization. On the other hand, we show that RNA can be a structural element in the formation of hydrogels. Moreover, in its hydrogel, RNA degradation by nucleases is accelerated. Thus, templates have a role beyond blueprints, protectors, and selectors. Template‐oligomer interactions can create new (micro)environments that might affect evolutionary dynamics.
Suspected muscular pseudohypertrophy in a dog: An atypical presentation of hypothyroidism
Authors: Bedel Florian , Girod Maud , Lecoindre Alexis 
Published: January 2025

AbstractA 4‐year‐old intact male border collie was presented with stiffness, reluctance to move and stridor. The owners reported a progressive muscle swelling, eventually restricting the dog's movement. Thyroid function tests revealed low free and total thyroxine levels with elevated thyrotropin (thyroid‐stimulating hormone) levels, indicating primary hypothyroidism. Computed tomography imaging showed marked muscle development without contrast enhancement. Muscular hypertrophy or pseudohypertrophy secondary to hypothyroidism was then suspected. Hormonal supplementation was implemented, leading to complete resolution of clinical signs within 2 months. Four years later, the dog remained well stabilised with no recurrence. This case report highlights an atypical manifestation of canine hypothyroidism with suspected muscle pseudohypertrophy, suggesting that hypothyroidism should be considered as a differential diagnosis of stiffness and reluctance to move with associated muscular hypertrophy or pseudohypertrophy in dogs.
Impact of Preoperative Glucagon‐Like Peptide‐1 Receptor Agonist on Outcomes Following Major Surgery
Authors: Rashid Zayed , Woldesenbet Selamawit , Khalil Mujtaba , Altaf Abdullah , Kawashima Jun , Mumtaz Khalid , Pawlik Timothy M. 
Published: January 2025

ABSTRACTBackgroundGlucagon‐like peptide‐1 receptor agonists (GLP‐1RA) are increasingly being used for the management of diabetes mellitus and obesity. We sought to define the impact of preoperative GLP‐1RA use on outcomes following major surgical procedures.MethodsPatients who underwent a major surgical procedure between 2013 and 2021 were identified using the IBM MarketScan database. Patients who took GLP‐1RA within a year before surgery were categorized as “exposed.” After propensity score matching (PSM), multivariable regression analysis was used to define the association of GLP‐1RA exposure with postoperative complications.ResultsAmong 138,980 patients (coronary artery bypass graft: n = 39,516, 28.4%; pneumonectomy: n = 4,881, 3.5%; abdominal aortic aneurysm repair: 4,459, 3.3%; pancreatectomy: n = 15,873, 11.4%; and colectomy: n = 74,251, 53.4%), most individuals were male (n = 80,871, 58.2%) with a median age of 58 (IQR 53–61) years. 2944 (2.2%) individuals had GLP‐1RA exposure before surgery. Overall incidence of complications was 36.5% (n = 50,724); complications included sepsis (n = 6,385, 4.6%), surgical site infections (n = 7,431, 5.3%), thromboembolism (n = 3,609, 2.6%), pneumonia (n = 4,783, 3.4%), renal (n = 9,017, 6.5%), or cardiopulmonary failure (n = 26,661, 19.2%). On unmatched analysis, patients on GLP‐1RA had a higher risk of complications (no GLP‐1RA: 36.3% vs. GLP‐1RA: 44.5% p < 0.001); however, after PSM to account for measured confounders, GLP‐1RA exposure was not associated with the odds of surgical complications (OR 0.99 95% CI 0.91–1.08; p > 0.05). Among patients using GLP‐1RA during the 2 weeks before surgery (n = 522, 17.7%), there was no association of GLP‐1RA with risk of complications (nonrecent GLP‐1RA: 44.7% vs. recent GLP‐1RA: 44.1%; p = 0.992).ConclusionsGLP‐1RA use was not associated with an increased risk of complications following major surgical procedures.
ChatGPT for Tailoring Software Documentation for Managers and Developers
Authors: Bala Saimir , Sahling Kristina , Haase Jennifer , Mendling Jan 
Published: January 2025

AbstractIn many agile software development projects, documentation is often missing, outdated, or written with only a technical perspective. Existing literature recognizes the importance of documentation quality, especially when it comes to its readability for diverse audiences. While recent advances in Large Language Models (LLMs) offer the potential to tackle these issues, the use of LLMs for software documentation remains unexplored. This paper investigates the use of ChatGPT to improve and adapt documentation to specific audiences. We apply ChatGPT-4 for alternative documentation production and measure the resulting text characteristics and readability. Twenty-five experts from management and development rate these different versions. Results show the suitability of ChatGPT for generating high-quality text for both audiences, with managers benefiting more from an adapted version.
Copilot’s Island of Joy
Authors: Wivestad Viggo Tellefsen , Barbala Astri , Stray Viktoria 
Published: January 2025

AbstractThis study assesses the integration of GitHub Copilot into agile software development practices in one of Norway’s largest public sector organizations. Through a quasi-experimental survey of 115 participants, we differentiate the attitudes of users and non-users of GitHub Copilot regarding their development routines. Findings reveal that Copilot users experience significantly greater focus on engaging tasks and less dependence on colleagues compared to non-users, while non-users maintain a more cautious stance on AI use in the public sector. Further, while users generally showed more positive attitudes and fewer frustrations, these differences were not statistically significant. The study advocates for a mindful adoption of AI tools in agile settings, balancing individual benefits with interdependence and team unity.
Can ChatGPT Suggest Patterns? An Exploratory Study About Answers Given by AI-Assisted Tools to Design Problems
Authors: Maranhão Junior João José , Correia Filipe F. , Guerra Eduardo Martins 
Published: January 2025

AbstractGeneral-purpose AI-assisted tools, such as ChatGPT, have recently gained much attention from the media and the general public. That raised questions about in which tasks we can apply such a tool. A good code design is essential for agile software development to keep it ready for change. In this context, identifying which design pattern can be appropriate for a given scenario can be considered an advanced skill that requires a high degree of abstraction and a good knowledge of object orientation. This paper aims to perform an exploratory study investigating the effectiveness of an AI-assisted tool in assisting developers in choosing a design pattern to solve design scenarios. To reach this goal, we gathered 56 existing questions used by teachers and public tenders that provide a concrete context and ask which design pattern would be suitable. We submitted these questions to ChatGPT and analyzed the answers. We found that 93% of the questions were answered correctly with a good level of detail, demonstrating the potential of such a tool as a valuable resource to help developers to apply design patterns and make design decisions.
Bridging Silos: Amplifying InnerSource Adoption Using an Activity Theory Perspective
Authors: Dillon Clare 
Published: January 2025

AbstractMy research explores the adoption of InnerSource, a practice that integrates open source methodologies within organizations to foster collaboration and overcome the traditional silo mentality. InnerSource and Agile implementations share many values such as transparency, employee empowerment, and a flexible response to change. InnerSource adoption can come before, after, or in parallel with Agile transformations. Despite the increasing recognition of InnerSource as a pivotal driver for developer productivity and its growing presence in industry discussions, academic research on the subject remains in its infancy. Leveraging my involvement with the InnerSource Commons community and drawing from Activity Theory, my research aims to fill critical gaps in our understanding of InnerSource adoption. Specifically, it investigates the activities organizations engage in to enable InnerSource, identifies blockers hindering its implementation, and proposes effective strategies to counteract these challenges. At the XP 2024 PhD Symposium, I intend to share some preliminary findings of my research, derived from a Systematic Literature Review and a pilot study with an InnerSource practitioner working group. My research not only seeks to advance theoretical knowledge in the field but also offers practical insights for organizations striving to change software development practices, contributing to a more collaborative and efficient software development environment.
Where Do Developers Admit their Security-Related Concerns?
Authors: Mock Moritz , Forrer Thomas , Russo Barbara 
Published: January 2025

AbstractDevelopers use different means to document the security concerns of their code. Because of all of these opportunities, they may forget where the information is stored, or others may not be aware of it, and leave it unmaintained for so long that it becomes obsolete, if not useless. In this work, we analyzed different sources of code documentation from four large-scale, real-world, open-source projects in an industrial setting to understand where developers report their security concerns. In particular, we manually inspected 2.559 instances taken from source code comments, commit messages, and issue trackers. Overall, we found that developers prefer to document security concerns in source code comments and issue trackers. We also found that the longer the comments stay unfixed, the more likely they remain unfixed. Thus, to create awareness among developers, we implemented a pipeline to remind them about the introduction or removal of comments pointing to a security problem.