bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characterization of patients with acute idiopathic pancreatitis using an administrative claims database in Japan
Authors: Imura Miki , Katada Jun 
Published: January 2023

Abstract
Background: Hypertriglyceridemia is one of the causes of idiopathic acute pancreatitis and atherosclerotic cardiovascular diseases. Most guidelines define fasting triglyceride levels greater than 150 mg/dL as hypertriglyceridemia; however the triglyceride level of patients with acute pancreatitis is not clear, nor is it known how much triglyceride level reduction can reduce cardiovascular events. This study aimed to characterize patients with acute idiopathic pancreatitis and especially focused on triglyceride levels, patient characteristics, pharmaceutical treatment, and prognosis.
Methods: In this retrospective analysis of an administrative claims database, patients hospitalized due to acute pancreatitis were selected, and idiopathic pancreatitis was identified using specific pre-determined ICD-10 codes. A Wilcoxon rank sum test was performed for the comparison of the means of the two cohorts, and Fisher's exact test was used to compare proportions between the cohorts. The comparison between idiopathic and non-idiopathic pancreatitis was performed using a log-rank test.
Results: Between April 1, 2008, and July 31, 2021, 44,005 patients were hospitalized for the treatment of pancreatitis; among them, 30,814 cases (70.0%) were categorized as idiopathic. The mean age of patients with idiopathic pancreatitis was 62.7±18.8 years, 68.8% of the patients were male, and the mean triglyceride levels within 3 days after hospitalization were 293.1±816.6 mg/dL. Rehospitalization due to recurrent pancreatitis and the incidence rates of cardiovascular events were 39.5% and 3.3%, respectively.
Conclusions: Patients with idiopathic pancreatitis had elevated triglyceride levels at admission. Even if triglyceride levels are not extremely high, hypertriglyceridemia might cause idiopathic pancreatitis. Therefore, there is a need for intervention in terms of triglyceride levels in patients with hypertriglyceridemia, not only to prevent cardiovascular disease, but also to prevent the onset and recurrence of acute pancreatitis.
Trial registration: Not applicable
Radio-immunotherapy by 188Re-antiCD20 and stable silencing of IGF-IR in Raji cells, new insight in treatment of lymphoma
Authors: Nasehi Leila , zadeh Baharak Abdolhossein , Rahimi Hossein , Ghahremani Mohammad hossein 
Published: January 2023

Abstract
Hematologic malignancies such as Non-Hodgkin’s lymphoma (NHL), remain a serious threat to human health due to their heterogeneity and complexity. The inherent genetic heterogeneity of NHL B-cells, as well as the instability of lymphoma cancer cells, results in drug resistance in lymphoma, posing a fundamental challenge to NHL treatment. Burkitt lymphoma (including Raji cell line) is a rare and highly aggressive form of B-cell NHL. Since overexpression of the insulin-like growth factor-1 receptor (IGF-1R) playing a prominent role in the development and transformation of different malignancies, especially lymphoma malignancies, we have explored the role of IGF-1R in the development and progression of Raji cells and the stable silencing of IGF-1R by lentivirus-mediated RNA interference (RNAi). We have shown that stable silencing of the IGF-1R gene in Raji cells using lentivirus-mediated-RNAi have resulted in a significant reduction in Raji cell proliferation. Moreover, the results of the cell viability assays indicated high resistance of Raji cells to rituximab. However, coupling rituximab to 188Re potentially leads to specific targeting of Raji cells by 188Re, improving the therapeutic efficacy. We found that the synergistic effect of using a gene therapy-based system in combination with radioimmunotherapy could be a promising therapeutic strategy in the future. To the best of our knowledge, this is the first study that reports the knock down of IGF-1R via lentiviral-mediated shRNA in Raji cells.
Effects of CALM intervention on neutrophil-to-lymphocyte ratio (NLR), fear of cancer recurrence and quality of life in patients with lung cancer
Authors: Zhao Jie , Wang Menglian , Huang Runze , Xu Jian , Gan Chen , Yu Sheng , Tang Lingxue , Yao Senbang , Li Wen , Cheng Huaidong 
Published: January 2023

Abstract
Purpose
This study aims to evaluate the effects of managing cancer and living meaningfully (CALM) intervention on the neutrophil-to-lymphocyte ratio (NLR), fear of cancer recurrence, quality of life and general distress in lung cancer patients and to explore whether there is a correlation between the NLR, fear of cancer recurrence, general distress and quality of life.
Methods
Eighty lung cancer patients with clinical range scores (≥13 points) on the FCRI severity subscale were recruited and randomly assigned to the CALM group or usual care (UC). The NLR was recorded before and after treatment. The Fear of Cancer Recurrence Inventory (FCRI), Quality of Life Questionnaire Core 30 (QLQ-C30) and Depression-Anxiety-Stress Scale (DASS-21) were used to evaluate patients at baseline (T0), immediately after treatment (T1), and at 2 (T2) and 4 (T3) months.
Results
Compared with the UC group, the NLR was significantly different before and after CALM intervention (z=-5.498; P=0.000). There were significant differences in the scores of QLQ, FCR and general distress (referring to depression and anxiety) before and after the T1, T2 and T3 interventions (F=220.30, F=315.20, F=290.10, respectively; P<0.001). The NLR in lung cancer patients was negatively correlated with QOL both before (r=-0.763; P<0.0001) and after the intervention (r=-0.810, P<0.0001). FCR and general distress were negatively correlated with the QOL scores in the CALM group (T0: r=-0.726, r=-0.776, respectively; P<0.0001; T1: r=-0.664, r=-0.647, respectively; P<0.0001; T2: r=-0.678, r=-0.695, respectively; P < 0.0001; T3: r=-0.511, P = 0.0008; r=-0.650, P<0.0001).
Conclusion
The CALM intervention can effectively reduce the NLR, alleviate the recurrence fear and general distress symptoms and improve the quality of life in lung cancer patients. Meanwhile, the NLR, fear of cancer recurrence and general distress were negatively correlated with quality of life. This indicates that the NLR can be used as a marker of the efficacy of the CALM intervention.
The discrimination of tectonic setting Using trace elements in zircons： A machine learning approach
Authors: Wang Luyuan , Zhang Chao , Geng Rui , Li Yuqi , Song Jijie , Wang Bin , Cui Fanghua 
Published: January 2023

Abstract
Zircon is the most important accessory mineral in geological research, and they record information on isotopes and trace elements which is of great significance in earth science research. Trace elements in Zircons can be used for analyzing the genesis of zircons, calculating the magma temperature and oxygen fugacity, and tracing the magma source. Due to the limitation of visual dimensions, the information on the zircons is mainly shown with the method of low dimensional diagrams in the present studies, so the high dimensional relationships during trace elements of the zircons are difficult to be discovered. However, with the development of machine learning, mining the high dimensional relationships during the trace elements of the zircons becomes possible. In this paper, four supervised learning algorithms including Random Forest, Support Vector Machine, Decision Tree, and eXtreme Gradient Boosting have been implemented to analyze trace elements of 3907 magmatic zircons from the GEOROC database, and a precise 13-dimensional data classifier model has been established in order to distinguish the tectonic settings of the rift, ocean island, and convergent margin. Based on the results of accuracy, precision, recall, and F1-score, the machine learning approach of eXtreme Gradient Boosting is best in the paper and the results of Accuracy, Precision, Recall, and F1-score are 0.948, 0.941, 0.922, 0.930, respectively. In summary, eXtreme Gradient Boosting in the paper could provide a high-dimensional discriminative approach to distinguish the tectonic settings.
Clinical utility of the acoustic detection of coronary stenosis as an early rule-out criterion: a blinded, prospective, monocentric study versus standard care
Authors: Birkemeyer Ralf , Wittenberg Jane , Müller Alfred , Wahler Steffen 
Published: January 2023

Abstract
Background:
The CADScor®System is a noninvasive and radiation-free technology that searches for stenosis induced by turbulent coronary blood flow. A CADSscore represents the acoustic detection results of coronary stenoses. We assessed consecutive patients with stable symptoms without known coronary artery disease (CAD) to define a low risk for obstructive CAD based on a low CAD score than a standard approach of clinical assessment using noninvasive and invasive diagnostic measurements.
Methods:
Overall, 214 consecutive patients aged ˃40 years in a German cardiological outpatient unit were included. Patients underwent an initial clinical assessment, a double-blinded CAD score, standard examinations, and a national guidance-based diagnostic cascade. They underwent a 6-month telephone follow-up to capture future CAD events. A CAD score of ≤20 was defined as low risk.
Results:
Overall, 196 patients completed the planned diagnostic workup after their initial visit, and 187 had a valid CAD score. All 196 patients underwent an electrocardiogram (ECG) and echocardiography, and 178 patients underwent a stress ECG. According to the initial standard evaluation, 41 patients were considered to be low-risk without further diagnosis. A CAD score of ≤20 was found in 51 patients. According to clinical standards, 85 and 77 patients underwent noninvasive testing and invasive angiography, respectively. The obstructive CAD was invasively diagnosed in 25 patients, of whom 4 had a CAD score of ≤20. No additional CAD was detected at the 6-month follow-up.
Overall, 41 of the 165 noninvasive and invasive diagnostic procedures could have been avoided with a CAD score of ≤20 as the exclusion criterion for further diagnosis after the standard initial diagnosis. Furthermore, 10 of the 52 invasive procedures without evidence of obstructive CAD could have been prevented.
Conclusions:
The obstructive CAD was confirmed in 12.8% of patients with stable symptoms and suspected CAD. Therefore, advanced noninvasive testing was mainly used for further CAD exclusion. The diagnostic yield of invasive angiography was low, and approximately a quarter of further diagnostic procedures could have been avoided with the CAD score, which showed an acceptable false-negative rate compared with the standard diagnostic tools.
Trial registration: Deutsches Register Klinischer Studien (DRKS): DRKS00016986 (22/03/2019)
Bioinformatic prediction of stage-specific transcription factor binding of Plasmopara halstedii conserved in the downy mildew and Phytophthora species
Authors: Bharti Sakshi , Thines Marco 
Published: January 2023

Abstract
Oomycetes, a large group of fungi-like organisms, include some destructive plant pathogens causing enormous economic damage. Phylogenetically, oomycetes belong to the kingdom Straminipila and have diverse lifestyles, including saprotrophs and both general and specialized pathogens of various eukaryotic supergroups. A rapid increase in genomic studies and next generation sequencing technologies have led to significant progress in understanding oomycete lifestyles. However, their genetics, including transcriptional regulation, have been studied to a much lesser extent. Here we provide a cross-species analysis of oomycete promoter for providing a first step towards elucidating gene regulation networks related to pathogenicity and life cycle stages. To identify conserved regulatory sequences involved in this, clustered DNA sequences of Plasmopara halstedii transcriptome time-series expression levels dataset from a preliminary study, has been used as a core reference for cross-species comparisons. Using a computational pipeline, 46 potential TFBSs motifs in 25 clusters with functionally conserved downstream genes of downy mildew and two Phytophthora species, regardless of the gene expression levels of Phytophthora transcriptomes were found. This can now be followed up by knock-out experiments in oomycete species amenable for genetic modification.
OncoVee TM -MiniPDX-guided anticancer treatment for HER2-negative intermediate-advanced gastric cancer patients: A single-arm, open-label phase I clinical study
Authors: Zhang Baonan , Li Yuzhen , Zhu Xiaodan , Chen Zhe , Huang Xiaona , Gong Tingjie , Zheng Weiwang , Bi Zhenle , Zhu Chenyang , Qian Jingyi , Li Xiaoqiang , Jin Chunhui 
Published: January 2023

Abstract
Background: Chemotherapy is the main treatment strategy for patients with advanced HER2-negative gastric cancer(GC); yet, many patients do not respond well to treatment. This study evaluated the sensitivity of a mini patient-derived xenograft (MiniPDX) animal model in patients with HER2-negative intermediate-advanced GC .
Methods: In this single-arm, open-label clinical study, we consecutively recruited patients with HER2-negative advanced or recurrent GC from September 2018 to July 2021. Tumor tissues were subjected to MiniPDX drug sensitivity tests for screening individualized anti-tumor drugs; appropriate drug types or combinations were selected based on drug screening results. The primary endpoints were progression-free survival (PFS) and safety, and the secondary endpoints were overall survival (OS) and objective response rate (ORR).
Results: A total of 17 patients were screened, and 14 eligible patients were included.The median follow-up time was 9 (2-34) months. The median PFS time was 14.1 (2-13) months, the median OS time was 16.9 (2-34) months, ORR was 42.9% (6/14), and DCR was 92.9% (13/14). The most common treatment-related adverse events (TRAE) were fatigue (14 (100%)), anorexia (13 (93%)) and insomnia (12 (86%)), and the most common grade 3 or worse TRAE was fatigue (6 (43%)), and anorexia (6 (43%)). The occurrence rate of myelosuppression, nausea and vomiting, abnormal liver enzymes, and other grade 3-4 chemotherapy adverse reactions were relatively low, and no grade 5 treatment-related adverse events occurred.
Conclusion: Screening of GC/GJC first-line chemotherapy regimens and targeted drugs based on the MiniPDX animal model showed relatively good tumor activity and good safety.
Breech vaginal delivery and risk of obstetric anal sphincter injuries
Authors: Leborne Perrine , de Tayrac Renaud , Zemmache Zakarya , Serrand Chris , Fabbro-Peray Pascale , Allegre Lucie , Vintejoux Emmanuelle 
Published: January 2023

Abstract
Introduction

Obstetric anal sphincter injuries (OASIs) at the time of childbirth can lead to serious consequences including anal incontinence, dyspareunia, pain and rectovaginal fistula. These types of lesions and their incidence have been well studied after cephalic presentation deliveries, but no publications have specifically addressed this issue in the context of vaginal breech delivery. The goal of our study was to evaluate the incidence of OASIs following breech deliveries and compare it with cephalic presentation births.

Methods

This was a retrospective cohort study involving 670 women. Of these, 224 and 446 had a vaginal birth of a fetus in the breech (breech group) and cephalic (cephalic group) presentations respectively. Both groups were matched for birthweight (± 200g), date of delivery (± 2 years) and vaginal parity. Main outcome of interest was to evaluate the incidence of OASIs following breech vaginal birth compared to cephalic vaginal births. Secondary endpoints were the incidence of intact perineum or first-degree tear, second-degree perineal tear and rates of episiotomies in each group.

Results

There was no statistically significant difference in OASIs incidence between the breech and cephalic groups (0.9% vs. 1.1%; OR 0.772 (0.133–4.479); p = 0.77). There were more episiotomies in the breech group (12.5% vs. 5.4%, p = 0.0012) and the rate of intact or first-degree perineum was similar in both groups (74.1% vs. 75.3%, p = 0.7291). A sub-analysis excluding patients with episiotomy and history of OASIs did not show any statistically significant difference either.

Conclusion

We did not demonstrate a significant difference in the incidence of obstetric anal sphincter injuries between women who had a breech vaginal birth compared to cephalic.
Seasonal variation in food security, lifestyle, nutritional status and its associated factors of the urban poor adolescents in Kuala Lumpur, Malaysia: research protocol of a prospective cohort study
Authors: Tay Janice Ee Fang , Tung Serene En Hui , Kaur Satvinder , Gan Wan Ying , Che’Ya Nik Norasma , Tan Choon Hui 
Published: January 2023

Abstract
Background: Climate change, obesity and undernutrition have now become a worldwide syndemic that threatens most people's health and natural systems in the 21st century. Adolescent malnutrition appears to be a matter of concern in Malaysia, and this is particularly relevant among the urban poor population. Mounting evidence points to the fact that underlying factors of malnutrition are subject to climate variability and profoundly affect nutritional outcomes. Hence, it is interesting to examine seasonal variation in nutritional status and its associated factors of urban poor adolescents in Malaysia.
Methods: This is a prospective cohort study following urban poor adolescents aged 10-17 years living in low-cost high-rise flats in Kuala Lumpur, Malaysia, across two monsoon seasons. The baseline assessment will be conducted during the onset of the Northeast Monsoon and followed up during Southwest Monsoon. Climate data will be collected by obtaining the climatological data (rainfall, temperature, and relative humidity) from Malaysia Meteorological Department. Geospatial data for food accessibility and availability, and also built (recreational facilities) environments, will be analyzed using the QGIS 3.4 Madeira software. Information on socio-demographic data, food security, lifestyle (diet and physical activity), and neighbourhood environment (food and built environment) will be collected using a self-administrative questionnaire. Anthropometric measurements, including weight, height, and waist circumference, will be conducted following WHO standardized protocol. WHO Anthro Plus was used to determine the height-for-age (HAZ) and BMI-for-age (BAZ). Anaemic status through biochemical analyses will be taken using HemoCue 201+ ® haemoglobinometer.
Discussion: The study will provide insights into the seasonal effects in nutritional status and its associated factors of urban poor adolescents. These findings can be useful for relevant stakeholders, including policymakers and the government sector, in seizing context-specific strategies and policy opportunities that are seasonally sensitive, effective, and sustainable in addressing multiple challenges to combat all forms of malnutrition, especially among urban poor communities.
Trial registration:The protocol for this review has not been registered.
The Impact of COVID-19 on Online Medical Education: A Knowledge Graph Analysis Based on Co-term Analysis
Authors: Deng Huijiao , Jiang Yi , Han Qinrong , Zhou Xingyu , Zhong Siyang , Hu Kai , Yang Lin 
Published: January 2023

Abstract
Background：This study aims to identify the characteristics and future directions of online medical education in the context of the novel coronavirus outbreak new through visual analytics using CiteSpace and VOSviewer bibliometric methods.
Method：From Web of Science, we searched for articles published between 2020 and 2022 using the terms online education, medical education and COVID-19, ended up with 2555 eligible papers, and the articles published between 2010 and 2019 using the terms online education, medical education and COVID-19, and we ended up with 4313 eligible papers.
Results：Before the COVID-19 outbreak, Medical students and care were the most frequent keywords and the most cited author was BRENT THOMA with 18 times. The United States is the country with the greatest involvement and research impact in the field of online medical education. The most cited journal is ACAD MED with 1326 citations. After the COVID-19 outbreak, a surge in the number of research results in related fields, and ANXIETY and four secondary keywords were identified. In addition, the concentration of authors of these publications in the USA and China is a strong indication that local epidemics and communication technologies have influenced the development of online medical education research. Regarding the centrality of research institutions, the most influential co-author network is Harvard Medical School in the United States; and regarding the centrality of references, the most representative journal to which it belongs is VACCINE.
Conclusion：This study found that hey information such as keywords, major institutions and authors, and countries differ in the papers before and after the COVID-19 outbreak. The novel coronavirus outbreak had a significant impact on the online education aspect. For non-medical and medical students, the pandemic has led to home isolation, making it difficult to offer face-to-face classes such as laboratory operations. Students have lost urgency and control over the specifics of face-to-face instruction, which has reduced the quality of teaching. Therefore, we should improve our education model according to the actual situation to ensure the quality of teaching while taking into account the physical and psychological health of students.
Clinical features and genetic analysis of Taiwanese primary immunodeficiency patients with prolonged diarrhoea and monogenetic inflammatory bowel disease
Authors: Lee Wen-I , Chen Chien-Chang , Chen Shih-Hsiang , Lai Wan-Tz , Jaing Tang-Her , Ou Liang-Shiou , Liang Chi-Jou , Kang Chen-Chen , Huang Jing-Long 
Published: January 2023

Abstract
Purpose: Diarrhoea lasting longer than 14 days which fails to respond to conventional management is defined as severe and protracted diarrhoea and might overlap with inflammatory bowel disease (IBD).
Methods: The prevalence, associated pathogens and prognosis of severe and protracted diarrhoea without IBD (SD) and with monogenetic IBD (mono-IBD) in primary immunodeficiency patients (PID) were investigated in Taiwan.
Results: A total of 301 patients were enrolled between 2003 and 2022, with predominantly paediatric-onset PID. Of these, 24 PID patients developed the SD phenotype before prophylactic treatment, including Btk (six), IL2RG (four), WASP, CD40L, gp91 (three each), gp47, RAG2 (one each), CVID (two) and SCID (one) without mutations. The most detectable pathogens were pseudomonas and salmonella (six each), and all patients were improved after approximately two-weeks antibiotic and/or IVIG treatment. Six (25.0%) mortalities without HSCT implement were due to respiratory failure from interstitial pneumonia (3 SCID and 1 CGD), intracranial haemorrhage (WAS), and lymphoma (HIGM). In the mono-IBD group, seventeen patients with mutant TTC7A (2), FOXP3 (2), NEMO (2), XIAP (2), LRBA (1), TTC37 (3), IL10RA (1), STAT1 (1), ZAP70 (1), PIK3CD (1), and PIK3R1 (1) genes failed to respond to aggressive treatment. Nine mono-IBD patients with TTC7A (2), FOXP3 (2), NEMO (2), XIAP (2) and LRBA (1) mutations were fatal in the absence of HSCT. The mono-IBD group had a significantly earlier age of diarrhoea onset (1.7 vs 33.3 months, p=0.0056), a longer TPN duration (34.2 vs 7.0 months, p<0.0001), a shorter follow-up period (41.6 vs 132.6 months, p=0.007) and a higher mortality rate (58.9 vs 25.0%, p=0.012) compared with the SD group.
Conclusion: When compared to those with the SD phenotype, the mono-IBD patients had significant early-onset and poor response to empiric antibiotics, IVIG and steroids. This should be confirmed by genetic analysis or/and faecal calprotectin. Anti-inflammatory biologics and suitable HSCT still have the potential to control or even cure the mono-IBD phenotype.