bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intraoperative Optical Coherence Tomography –Available Technologies and Possibilities of Use. A Review
Authors: Benda Tomáš , Studený Pavel 
Published: December 2022

Optical coherence tomography (OCT) is a non-contact and non-invasive imaging and diagnostic method, that allows the imaging of ocular tissues on transverse sections in extremely high quality of micrometer resolution. The physical principle of OCT is analogous to ultrasound, but it uses infrared radiation instead of acoustic waves. By using a low coherent radiation source, it is possible to achieve a higher resolution. Based on the obtained data, the computer can reconstruct two or three-dimensional images of the examined tissue. In recent years, we have seen a rapid development in ophthalmic surgery, especially in surgical instruments and imaging methods. However, the technology of surgical microscopes does not change significantly and thus becomes a limiting factor in the development of ophthalmic microsurgery. The integration of the OCT into surgical microscopes, so the introduction of the Intraoperative Optical Coherence Tomography (iOCT), opens up further possibilities for displaying/looking at the operating field and adapting surgical techniques to the current situation during the surgery. On the contrary, the disadvantage is the prolongation of the surgery time and thus the theoretical increase in possible complications related to the surgery. iOCT can be used for operations on the anterior and posterior segment of the eye. In anterior segment surgery, it is used mostly in penetrating and lamellar keratoplasty, glaucoma surgery and cataract surgery. In posterior segment surgery, it is used during pars plana vitrectomy. The aim of the article is to provide a comprehensive overview of the current possibilities of using iOCT in eye surgery.
En Bloc Resection of Retinal Vasoproliferative Tumor Using 23g Vitrectomy. A Case Report
Authors: Forgáč František , Sekerešová Monika , Černák Martin 
Published: December 2022

Purpose: Retinal vasoproliferative tumor is one of the benign vascular tumors which in advanced stages leads to exudative retinal detachment with the formation of epiretinal and subretinal membranes. In such advanced stages, one of the therapeutic options is pars plana vitrectomy. This article presents the case of a patient on whom was performed 23-gauge pars plana phacovitrectomy with en bloc resection of the tumor followed by histological confirmation.
Case report: A 70-year-old patient with a one-year history of unilateral loss of vision in his left eye was admitted to our clinic for examination in February 2018. At admission, the best corrected visual acuity in the right eye was 1.0, and in the left eye was light perception. Based on the clinical picture, sonographic examination of the eye, and fluorescein angiography, the patient was diagnosed with a retinal vasoproliferative tumor. Due to the advanced stage of disease, we proceeded with surgical intervention. We performed 23-gauge phacovitrectomy with a bloc resection of the tumor. Subsequent histological examination confirmed the presence of the presumed tumor. The follow-up exam a few months later showed a completely attached retina with silicone oil tamponade, without exudative retinopathy. However, the best corrected visual acuity improved only slightly to the ability to count fingers at one meter.
Conclusion: Pars plana vitrectomy with en bloc resection of retinal vasoproliferative tumor is one of the therapeutic modalities in advanced stages.
Chelation of Band Keratopathy in Long-Term Observation
Authors: Kristian Petr , Cholevík Daniel 
Published: December 2022

Aim: To report the clinical results of chelation of band keratopathy in long-term follow-up.
Material and methods: The long-term results of 5 patients (5 eyes) with symptomatic band keratopathy with a follow-up period of at least 6 months, in whom 2% EDTA was chelated on the affected eye in the study period from April 2018 to March 2021, were retrospectively evaluated. The follow-up period was 9-37 months.
Results: In all patients, there was a significant improvement in the local findings and an increase in the transparency of the cornea. The effect of therapy was verified on a color photograph of the anterior segment and on AS-OCT by the disappearance of subepithelial hyperreflective foci and accompanying optical shadows. Postoperatively, this enabled a more detailed visualization of the deeper layers of the cornea and other structures of the anterior segment. In a patient with the potential to improve vision, it was also possible to significantly improve visual functions. In the other three patients with pain in the affected eye, the pain subsided, and they also benefited cosmetically from the operation.
Conclusion: Based on our experience and previously published reports, EDTA corneal chelation is able to causally resolve the pathology and improve vision in eyes with visual potential. At the same time, it reduces discomfort and has an analgesic effect in long-term irritated eyes. The operation is also suitable for amaurotic, cosmetically unsightly bulbs, as a successful intervention preserving the eye and improving the appearance of such eyes leads to satisfaction and a subjective increase in the quality of life of the patients.
Tubulointerstitial Nephritis With Uveitis (Tinu Syndrome). A Case Report
Authors: Kurašová Ester , Orság Jiří , Klementa Viktor , Krejčí Karel 
Published: December 2022

In this case report, we describe the case of a 50-year-old woman referred by her general practitioner to a pulmonologist in order to investigate persistent fever and elevation of C-reactive protein despite antibiotic treatment following a respiratory infection. The patient was examined extensively, during which rheumatology, gastroenterology, nephrology, ophthalmology, laboratory and imaging tests were performed. Due to a rapid progression of renal insufficiency with active urinary sediment, the patient was referred for a renal biopsy, which confirmed tubulointerstitial nephritis, followed by a diagnosis of bilateral anterior uveitis two months later - genetic testing was also conducted, which confirmed the diagnosis of tubulointerstitial nephritis with uveitis syndrome. Steroid treatment brought about a gradual reduction of proteinuria and a stabilisation of renal function.
snoRNAs are Deregulated in Patients with Parkinson’s Disease
Authors: TOKGÜN Pervin Elvan , TOMATIR Ayşe Gaye , SARIEKİZ Fatma Gizem , BİR Sinan 
Published: December 2022

Purpose: Small nucleolar RNAs are ranging from 65 to 300 nucleotides in length that mediate post-transcriptional RNA modifications. They don’t have a 5′-Cap and a poly-A tail and are categorized as C/D box snoRNAs, H/ACA box snoRNAs, and small Cajal body-specific RNAs. snoRNAs have essential roles in important biological processes such as transcription, RNA splicing, cell cycle, and etc. In this study, we tried to reveal differential expressions of snoRNAs in PBMCs of patients with Parkinson’s Disease by microarray analysis.
Materials and methods: Patients (n=3) who are considered to have a unilateral onset history and a good response to dopaminergic treatment in the first years were included in the study. 10 ml peripheral blood sample was taken for peripheral blood mononuclear cell isolation. Total RNA was extracted using GeneAll® Hybrid-R™ kit and microarray analysis was performed by using Affymetrix GeneChip Human ST 2.0 platform. Raw data were extracted using Affymetrix Command Console Software 1.1. KEGG pathway and GO terms analyses were performed and protein-protein interaction of host genes were determined by using STRING database.
Results: Data from patients revealed that there were 28 snoRNAs were downregulated and 3 snoRNAs were upregulated.
Conclusion: Here in this study, we evaluated the differential expressions of snoRNAs in patients with a definitive diagnosis of PD by microarray analysis and observed deregulated expressions of some snoRNAs. Differential expression of snoRNA may cause changes in the transcriptional activity of host genes and thus can serve as biomarkers for diseases.
National Registry of Patients with Chronic Kidney Disease and Patients with Acute Kidney Injury 20 years: acquisitions and perspectives
Authors: Kolesnyk M. , Kozliuk N. , Razvazhaeva O. 
Published: December 2022

The history of the establishment of the National Registry is rather complicated and proceeds in several stages. It started in 2002, and the multistage nature of the Registry is related to the medical and technological changes that ensure the functioning of the registry (modification of the individual registration forms and the reporting form), as well as to the target groups of patients (patients with chronic kidney disease, kidney transplant recipients, or patients with acute kidney injury).
The National Registry is managed by its coordinating committee, and regional registries are managed by regional coordinators. The rating evaluation of the status of medical care of nephrology patients in Ukrainian regions and Kyiv is prepared annually based on the regional registries.
We believe that the transformation of the effective aggregated version of the Registry into an online version is necessary and perspective.
Blood levels of pro- and anti-inflammatory cytokines in children after acute kidney injury at different stages of observation
Authors: Driianska V. , Lavrenchuk O. , Bagdasarova I. , Fomina S. , Kholod V. , Nepomnyashchii V. 
Published: December 2022

Identifying the factors for progression of kidney pathology after acute kidney injury (AKI) in children is important for making clinical decisions and creating strategies for the prevention and treatment of chronic kidney disease (CKD).
The present study aimed to investigate the value of serum levels of tumor necrosis factor α (TNF-α) and transforming growth factor (TGF-β) as markers of CKD progression in children after AKI.
Methods. In this cross-sectional cohort study, the levels of serum cytokines were studied in 63 children from 6 months to 18 years old who had undergone AKI and 10 healthy children (reference group) using ELISA. The peculiarities of those who recovered (n=14) and those who were subsequently diagnosed with CKD stage 1 ​ (n=22) or CKD stages 2-3 (n=27) were determined. An analysis was also carried out taking into account the duration from the episode of AKI: early recovery period up to 3 months (n=21), 3-12 months (n=9), 1-3 years (n=22), and more than 3 years (n=11). “SPSS for Windows. Version 11" - Student's test or Mann-Whitney Rank Sum Test was used. The correlation analysis was determined using the Pearson (r) or Kendall/Spearman method (ρ).
Results. An increase in serum levels of the anti-inflammatory but pro-sclerotic TGF-β was observed in all children convalescing with AKI regardless of disease progression, with mean levels of the indicator increasing in the delayed phase. An increase in TGF-β levels ≥40.5 pg/mL in the first 3 months after AKI was documented in patients with an unfavorable disease course, such that these patients could be classified as a risk group for the development of fibrotic complications.
No peculiarities in mean serum levels of proinflammatory TNF-α were observed in children who had suffered AKI, and there was no significant difference when comparing the groups according to the consequences of the disease. In the individual analysis, it was found that after the 12th month of observation, a high TNF-α level (≥8.0 pg/ml) was associated with an increase in the proportion of patients with CKD 2-3 (p < 0.001), which can be used to predict disease progression.
Conclusions. This study demonstrates the feasibility of determining serum levels of TNF-α and TGF-β in children with AKI, which could be used as potential predictors of CKD risk to optimize treatment and prevention.
Peculiarities of serum levels of vascular growth factor and its receptors in dialysis patients
Authors: Driianska V. , Dudar I. , Shifris I. , Poroshina T. , Savchenko V. , Kononova G. 
Published: December 2022

Recent research has shown that VEGF may influence the condition and survival of patients with chronic kidney disease (CKD), including those treated with dialysis procedures. Identifying the value of this factor is important to uncover the mechanisms of CKD progression and improve treatment strategies.
The present study aimed to determine the mean serum levels of vascular endothelial growth factor (VEGF) and its receptor (VEGF-R) and their correlations with pro-inflammatory cytokines (TNF-α, MCP-1, IL -6, IL -8) in dialysis patients stratified by dialysis modality and Carnivit use.
Methods. In this prospective cohort study, serum levels of VEGF, VEGF-R, and proinflammatory cytokines were determined in 41 hemodialysis (HD) patients (group 1) and 14 peritoneal dialysis (PD) patients (group 2), 28 of whom were treated with Carnivit. The assay was performed with the enzyme immunoassay "SunRise TouchScreen" using IBL International (Germany) test systems. The limits of normal values (reference range) were determined based on the results of a study with 20 conditionally healthy individuals.
Results. All included patients had significantly higher serum levels of VEGF compared to healthy donors (p=0.006); a significant increase in this mediator was observed in both HD and PD treated subjects (p=0.002 and p=0.007, respectively). Carnivit treatment resulted in a significant decrease (p=0.023) in this mediator to normal levels in all patients. Subgroup analysis showed a significant decrease in VEGF (p=0.016) and VEGF-R (p=0.005) in HD patients after therapy. Mean concentrations of growth factor in HD patients (p=0.098) and PD patients (p=0.160) did not differ from those of healthy subjects.
A positive correlation was observed between serum levels of VEGF and its receptors in the studied patients both before and after treatment (p < 0.0001).
A direct correlation between IL -8 and VEGF and VEGF-R was observed in HD patients and an inverse correlation between MCP-1 and VEGF-R was observed in PD patients. After Carnivit treatment, the correlation between serum levels of IL -8 and VEGF-R (0.782, p=0.01) and between VEGF and VEGF-R (0.770, p=0.01) remained in group 1 and between VEGF and VEGF-R (0.829, p=0.03) in group 2.
Conclusion. Increased concentrations of VEGF and its receptors were detected in the blood of dialysis patients, with a positive correlation between them and the pro-inflammatory IL -8. Treatment with Carnivit resulted in a significant decrease in cytokines with the maintenance of the balance between vascular growth factor and its receptors, which we consider a positive effect for the inhibition of inflammation with the progression of endothelial dysfunction.
Od kryzysu samorządności do kryzysu funkcjonowania wspólnoty samorządowej
Authors: Wojtyła Wojciech 
Published: December 2022

Celem artykuł jest spojrzenie na problem samorządności i wspólnoty samorządowej przez pryzmat wartości, na których opiera się etyka personalistyczna. Autor dowodzi, że najgłębsze źródła zaburzeń w funkcjonowaniu wspólnot samorządowych oraz przyczyny problemów realizacji właściwych im zadań publicznych tkwią przede wszystkim w niedocenieniu lub w wielorakiej dewastacji podmiotowego wymiaru samorządności. Twierdzi również, że szczególnym wyzwaniem dla wszelkich podmiotów administrujących jest opieranie naturalnej dla samorządności władzy demokratycznej na fundamencie uniwersalnych wartości, które nie tylko będą chroniły samorządność, ale które będą przede wszystkim zapewniały jej żywotność i rozwój.
Prawna regulacja Rady Naukowej Instytutu Ochrony Środowiska – Państwowego Instytutu Badawczego
Authors: Dąbrowski Tomasz 
Published: December 2022

W literaturze przedmiotu zauważalny jest brak opracowań poruszających kwestię prawnych aspektów funkcjonowania rady naukowej instytutu badawczego, nikt nie pokusił się również o przedstawienie prawnych regulacji działania takiej rady w konkretnym instytucie. Celem artykułu jest analiza regulacji prawnych dotyczących rady naukowej Instytutu Ochrony Środowiska – Państwowego Instytutu Badawczego. W tekście przedstawiono historię oraz uregulowania prawne dotyczące struktury i sposobu funkcjonowania tego organu, omówiono aspekty historyczne jego powstania, skład oraz proces powoływania i odwoływania członków rady naukowej, ich prawa i obowiązki, a także zadania rady. Zaprezentowano tryb obradowania i podejmowania uchwał, jak również sposób dokumentowania działalności tego organu. Przedmiotem opracowania jest zatem z jednej strony prezentacja i charakterystyka rady naukowej instytutu, z drugiej zaś zaproponowanie nowych rozwiązań prawnych, obejmujących różne aspekty działania tego organu. Ich wprowadzenie przełożyłoby się na poprawę funkcjonowania instytutu, którego aktywność wpisuje się w działalność państwa. Praktyka funkcjonowania znowelizowanych przepisów zawartych w ustawie o instytutach badawczych, które dotyczą rady naukowej, zdaniem autora tekstu wskazuje, że wymagają one doprecyzowania bądź ponownego uregulowania niektórych kwestii na poziomie przepisów ustawowych. Wnioski końcowe wskazują, że rada naukowa jest organem stanowiącym, inicjującym, opiniodawczym i doradczym w zakresie działalności statutowej instytutu oraz w sprawach rozwoju kadry naukowej i badawczo-technicznej. Jej uprawnienia stanowią katalog zamknięty i są enumeratywnie wymienione przez ustawodawcę. Jako organ kolegialny, rada działa na podstawie przepisów ustawy o instytutach badawczych, statutu instytutu, a także postanowień uchwalonego przez siebie regulaminu. Regulamin ten, jako akt wewnętrzny, powinien być dostosowany do potrzeb konkretnej rady naukowej. Musi być sporządzony na piśmie i nie może być sprzeczny z postanowieniami ustawy ani statutu. W opracowanie regulaminu rady powinni być zaangażowani wszyscy jej członkowie – co często w praktyce jest pomijane. Ważne, aby regulamin precyzyjnie normował kwestie takie jak organizacja rady naukowej, komisji i zespołów, tryb pracy rady oraz podejmowania przez nią uchwał.
Karl Barth. «The Epistle to the Romans»: Breaking of the Liberal Paradigm
Authors: Алексий Миндров, 
Published: December 2022

Либеральная теология и обусловленная ею парадигма на долгие годы определила методологические подходы в западной библеистике. Опыт критического осмысления наследия либеральных теологов, проведённый Карлом Бартом, позволил вновь вернуть библейские дисциплины на почву изучения Слова Божия с точки зрения Его Предмета. Не умаляя значение историко-критического метода (ИКМ), К. Барт показал, что, несмотря на имеющийся историко-культурный и религиозный разрыв между нашим временем и временами св. апостола Павла, он вполне преодолим, поскольку Предмет, к Которому обращается апостол Павел, неизменно пребывает единым во все времена.
The liberal theology and its paradigm for many years defined methodological approaches in the western Biblical Studies. The experiment of critical judgment of the liberal theology heritage made by Karl Bart allowed returning Biblical Studies to the soil of studying the God’s Word in terms of its Subject again. Without belittling the value of the history-critical method (HCM), Bart showed that, in spite of the historical and cultural and religious gap between our time and times of the St. Paul, it is quite surmountable as the Subject which the apostle Paul steadily addresses stays uniform at all times.
«Distance» in the Theology of J.-L. Marion
Authors: Александр Александрович Солонченко, 
Published: December 2022

В статье анализируется концепция дистанции в богословском проекте Ж.-Л. Мариона. Автор проводит сравнительный анализ взглядов Мариона с идеями Э. Левинаса и Г. У. фон Бальтазара. В первой части даётся описание идеи бесконечного и понятия «Другой» у Левинаса. Во второй части статьи анализируется концепция дистанции в богословии Бальтазара, выделяются четыре различных уровня употребления этого понятия. В третьей части выявляются основные смыслы, цели и назначения понятия «дистанция» у Мариона, показываются сходства и различия с идеями Левинаса и Бальтазара. Автор приходит к заключению, что у всех трёх мыслителей «дистанция» - это не пространственная категория, указывающая на радикальное отличие, онтологическую инаковость полюсов, между которыми она «пролегает». Помимо тех четырёх уровней, на которых применяет «дистанцию» Бальтазар, Марион использует эту категорию для разработки метода иконического богословия. В этом случае «дистанция» призвана показать несводимость Бога к любым рациональным учениям о Нём. На этом уровне «дистанция» у Мариона исполняет ту же роль, что и «аналогия бытия» у Бальтазара, но, в сравнении с «аналогией бытия», «дистанция» делает больший акцент на несходстве полюсов.
The article is devoted to the analysis of the concept of «distance» in the theological project of J.-L. Marion. The author conducts a comparative analysis of Marion’s views with the ideas of E. Levinas and H. U. von Balthasar. The rst part gives a description of the idea of the in nite and the concept of «the Other» by Levinas. The second part of the article analyzes the concept of distance in Balthazar's theology, identi es four different levels of use of this concept. The third part of the article reveals the main meanings, goals and purposes of the concept of «distance» in Marion, shows the similarities and differences with the ideas of Levinas and Balthazar. The author comes to the conclusion that for all three thinkers’ «distance» is not a spatial category that indicates a radical difference, the ontological otherness of the poles between which it «lies». In addition to the four levels at which Balthazar applies «distance», Marion uses this category to develop the method of iconic theology. Here «distance» is intended to show the irreducibility of God to any rational teachings about Him. At this level, Marion's «distance» plays the same role as Balthazar’s «analogy of being», but in comparison with the «analogy of being», «distance» puts more emphasis on the dissimilarity of the poles.
The Problem of «Historical Jesus» in Russia at the End of the 19th Century on the Example of the Books of D. F. Strauss
Authors: Дмитрий Вячеславович Ларионов, , Александр Ларионов, 
Published: December 2022

В настоящей публикации рассматривается восприятие русскими авторами второй половины XIX в. популярных в Европе и новых для того времени идей Тюбингенской школы на примере книг Давида Фридриха Штрауса, видного представителя библейской рационалистической критики и автора «мифической теории». Цель исследования - показать, насколько неоднозначно в русском образованном обществе были восприняты актуальные для Европы богословские тенденции. В статье представлен разнообразный спектр мнений российских авторов XIX в. относительно творчества немецкого теолога.
This publication examines the perception by Russian authors of the second half of the 19th century of the popular in Europe and new for that time ideas of the Tübingen school on the example of the books of David Friedrich Strauss, a prominent representative of biblical rationalist criticism and the author of the «mythical theory». The purpose of the study is to show how ambiguous the theological trends relevant to Europe were perceived in the Russian educated society. The article presents a diverse range of opinions of Russian authors of the 19th century regarding the work of the German theologian.