bluuebunny/crossref_metadata_2025_split huggingface dataset:
Complexes of a model trimeric acylphloroglucinol with a Cu2+ ion: a DFT study
Authors: Mammino Liliana 
Published: March 2023

Abstract
Acylphloroglucinols (ACPLs, derivatives of phloroglucinol having at least one R−C=O group) are gaining increasing attention for their pharmacological potentialities. The presence of phenol OHs in their molecules confers antioxidant properties to ACPLs. Some ACPLs have already been identified as promising antioxidants for pharmaceutical purposes. Antioxidant properties may also be useful for a variety of other applications, including industrial ones. A viable option to verify and compare the antioxidant efficacy of compounds considers their ability to form complexes with a metal ion and reduce its charge. The present work considers a model structure maintaining all the identifying features of trimeric ACPLs (ACPLs containing three phloroglucinol moieties linked by methylene bridges) and studies the complexes of representative conformers with a Cu2+ ion, with the ion binding in turn to each of the available binding sites. Two series of calculations are performed at the DFT/B3LYP/6-31+G(d,p) level, without and with the Grimme’s D3 dispersion correction: the former series enables meaningful comparisons with previous calculations of complexes of other ACPLs, and the latter series is meant to evaluate the effect of taking dispersion into account on the estimation of the complexes’ properties. The results show that the Cu2+ ion is reduced to Cu+ ion. The molecule–ion interaction energy and the charge and spin density on the ion are comparable with those of complexes of known antioxidant ACPLs.
LIQ HD (Lick Instance Quantifier Home Cage Device): An Open-Source Tool for Recording Undisturbed Two-Bottle Drinking Behavior in a Home Cage Environment
Authors: Petersen Nicholas , Adank Danielle N. , Raghavan Ritika , Winder Danny G. , Doyle Marie A. 
Published: March 2023

AbstractInvestigation of rodent drinking behavior has provided insight into drivers of thirst, circadian rhythms, anhedonia, and drug and ethanol consumption. Traditional methods of recording fluid intake involve weighing bottles, which is cumbersome and lacks temporal resolution. Several open-source devices have been designed to improve drink monitoring, particularly for two-bottle choice tasks. However, beam-break sensors lack the ability to detect individual licks for bout microstructure analysis. Thus, we designed LIQ HD (Lick Instance Quantifier Home cage Device) with the goal of using capacitive sensors to increase accuracy and analyze lick microstructure, building a device compatible with ventilated home cages, increasing scale with prolonged undisturbed recordings, and creating a design that is easy to build and use with an intuitive touchscreen graphical user interface. The system tracks two-bottle choice licking behavior in up to 18 rodent cages, or 36 single bottles, on a minute-to-minute timescale controlled by a single Arduino microcontroller. The data are logged to a single SD card, allowing for efficient downstream analysis. LIQ HD accuracy was validated with sucrose, quinine, and ethanol two-bottle choice tasks. The system measures preference over time and changes in bout microstructure, with undisturbed recordings tested up to 7 d. All designs and software are open-source to allow other researchers to build on the system and adapt LIQ HD to their animal home cages.
LncRNA LITATS1 suppresses TGF‐β‐induced EMT and cancer cell plasticity by potentiating TβRI degradation
Authors: Fan Chuannan , Wang Qian , Kuipers Thomas B , Cats Davy , Iyengar Prasanna Vasudevan , Hagenaars Sophie C , Mesker Wilma E , Devilee Peter , Tollenaar Rob A E M , Mei Hailiang , ten Dijke Peter 
Published: March 2023

AbstractEpithelial cells acquire mesenchymal phenotypes through epithelial‐mesenchymal transition (EMT) during cancer progression. However, how epithelial cells retain their epithelial traits and prevent malignant transformation is not well understood. Here, we report that the long noncoding RNA LITATS1 (LINC01137, ZC3H12A‐DT) is an epithelial gatekeeper in normal epithelial cells and inhibits EMT in breast and non‐small cell lung cancer cells. Transcriptome analysis identified LITATS1 as a TGF‐β target gene. LITATS1 expression is reduced in lung adenocarcinoma tissues compared with adjacent normal tissues and correlates with a favorable prognosis in breast and non‐small cell lung cancer patients. LITATS1 depletion promotes TGF‐β‐induced EMT, migration, and extravasation in cancer cells. Unbiased pathway analysis demonstrated that LITATS1 knockdown potently and selectively potentiates TGF‐β/SMAD signaling. Mechanistically, LITATS1 enhances the polyubiquitination and proteasomal degradation of TGF‐β type I receptor (TβRI). LITATS1 interacts with TβRI and the E3 ligase SMURF2, promoting the cytoplasmic retention of SMURF2. Our findings highlight a protective function of LITATS1 in epithelial integrity maintenance through the attenuation of TGF‐β/SMAD signaling and EMT.
Frizzled receptors facilitate Tiki inhibition of Wnt signaling at the cell surface
Authors: Li Mingyi , Zheng Jing , Luo Dong , Xu Kai , Sheng Ren , MacDonald Bryan T , He Xi , Zhang Xinjun 
Published: March 2023

AbstractThe membrane‐tethered protease Tiki antagonizes Wnt3a signaling by cleaving and inactivating Wnt3a in Wnt‐producing cells. Tiki also functions in Wnt‐receiving cells to antagonize Wnt signaling by an unknown mechanism. Here, we demonstrate that Tiki inhibition of Wnt signaling at the cell surface requires Frizzled (FZD) receptors. Tiki associates with the Wnt‐FZD complex and cleaves the N‐terminus of Wnt3a or Wnt5a, preventing the Wnt‐FZD complex from recruiting and activating the coreceptor LRP6 or ROR1/2 without affecting Wnt‐FZD complex stability. Intriguingly, we demonstrate that the N‐terminus of Wnt3a is required for Wnt3a binding to LRP6 and activating β‐catenin signaling, while the N‐terminus of Wnt5a is dispensable for recruiting and phosphorylating ROR1/2. Both Tiki enzymatic activity and its association with the Wnt‐FZD complex contribute to its inhibitory function on Wnt5a. Our study uncovers the mechanism by which Tiki antagonizes Wnt signaling at the cell surface and reveals a negative role of FZDs in Wnt signaling by acting as Tiki cofactors. Our findings also reveal an unexpected role of the Wnt3a N‐terminus in the engagement of the coreceptor LRP6.
THE MEDIATING EFFECT OF HAPPINESS AT WORKPLACE ON THE RELATIONSHIP BETWEEN HYBRID WORK MODEL AND EMPLOYEE RETENTION IN IT INDUSTRY
Authors: R. Santiago Antony Selvi  , Vandana Madhavkumar  
Published: March 2023

The word “Great Resignation” is shaking up many organizations across different sectors in the world. The Covid-19 pandemic significantly changed the employees’ views on their careers. During the Covid-19 pandemic, organizations mostly used the flexible work arrangements like work from home (WFH) or remote work (RW) and hybrid work model (HWM) to run their business activities ensuring safety of employees. Work from home option and hybrid work is changing the work dynamics. It has become a significant reason for the employees especially women employees to continue their employment as they can also continue care-giving at home and do remote work. It has been reported that they were quitting their jobs when organizations insisted on them being physically present in the office. The purpose of this study is to determine the impact of hybrid work model on happiness at work and employee retention and also to find out does the happiness at work mediate on the relationship between hybrid work and employee retention. Hence, the empirical study was conducted among employees working in IT companies. The sample size was 200 and the collected data was analyzed using SPSS and AMOS. Hybrid work model was found to provide employees the space and flexibility to manage their professional and personal life and also increase their happiness at work. Happiness at work was found to positively impact retention of employees and mediates on the relationship between hybrid work model and employee retention. In the situation of a high shortage of skilled employees, the hybrid work model could be the most effective method to attract and retain skilled employees, since it influences the employee’s intention to stay or quit their job. The findings of the study will be help organizations to design the modern workplace with futuristic development and to retain talents.
Apuntes sobre el antiimperialismo y el proimperialismo de Haya de la Torre en Repertorio Americano
Authors: Barrera Rivera Dan Abner 
Published: March 2023

This article is a critical approach to the Peruvian politician Víctor Raúl Haya de la Torre, based on his writings published in the Costa Rican journal Repertorio Americano between November 1924 and August 1955. We found 73 texts by the author and 29 texts by another authors. Due to Repertorio, Haya became internationally known as one of the most representative voices of anti-imperialism. But this position is only one face of the Peruvian politician.We discovered in these texts his radical transformation in favor of imperialism. This is a less known change that we are interested in analyze.
Paauglio politrauma žemdirbystės pramonėje: klinikinio atvejo analizė
Authors: Bagdonaitė Kamilė , Sugintaitė Emilija , Dekerytė Inga , Lukošiūtė-Urbonienė Aušra , Kilda Artūras 
Published: March 2023

Polytrauma is a condition when a patient has sustained multiple injuries, which can lead to disability or death. While the agriculture industry is growing, the number of polytrauma patients in children is increasing as well. It is high-energy traumas when it is important to immediately assess injuries and life-threatening conditions and to start trauma protocols guided treatment. In this article, we present a case of a 17-year-old boy who suffered extensive injuries caused by a straw pellets machine. We discussed the importance of prehospital care, multidisciplinary team involvement, and treatment methods.
Impact of the COVID-19 pandemic on Muslim older immigrants in Edmonton, Alberta: A community-based participatory research project with a local mosque
Authors: Rehmani Amyna Ismail , Abdi Khadija , Mabrouk Esra Ben , Zhao Tianqi , Salami Bukola O. , Jones Allyson , Tong Hongmei , Salma Jordana 
Published: March 2023

Abstract
Objective
Older Muslim immigrants experience multiple vulnerabilities living in Canada. This study explores the experiences of Muslim older adults during the COVID-19 pandemic to identify ways to build community resilience as part of a community-based participatory research partnership with a mosque in Edmonton, Alberta.

Methods
Using a mixed-methods approach, check-in surveys (n = 88) followed by semi-structured interviews (n = 16) were conducted to assess the impact of COVID-19 on older adults from the mosque congregation. Quantitative findings were reported through descriptive statistics, and thematic analysis guided the identification of key findings from the interviews using the socio-ecological model.

Results
Three major themes were identified in consultation with a Muslim community advisory committee: (a) triple jeopardy leading to loneliness, (b) decreased access to resources for connectivity, and (c) organizational struggles to provide support during the pandemic. The findings from the survey and interviews highlight various supports that were missing during the pandemic for this population.

Conclusion
The COVID-19 pandemic exacerbated the challenges associated with aging in the Muslim population and contributed to further marginalization, with mosques being sites of support during times of crises. Policymakers and service providers must explore ways of engaging mosque-based support systems in meeting the needs of older Muslim adults during pandemics.
Impact of COVID-19 on lifestyles related etiquette among nursing staff in India: a cross sectional descriptive e-survey
Authors: Kalal Nipin , K Sharma Suresh , Rana Nimarta , Kumar Ashok 
Published: March 2023

Objective. To analyze the impact of COVID-19 pandemics on lifestyle-related etiquettes like eating, physical activity, and sleep behavior among nursing staff in India.
Methods. A cross sectional descriptive E-survey was conducted among 942 nursing staff. The validated electronic survey questionnaire was used to assess the changes in lifestyle-related etiquette before and during COVID-19 Pandemic.
Results. A total of 942 responses (mean age 29.01±5.7years) were collected, 53% of the respondents were men. A slight decline in healthy meal consumption pattern (p<0.0001) and a restriction of unhealthy food items were observed (p<0.0001), and also reduction in physical activity coupled with decreased participation in leisure-related activities was seen (p<0.0001). The stress and anxiety slightly increase during COVID–19 pandemics (p<0.0001). Additionally, social support extended by family and friends to maintain healthy lifestyle-related behaviors also significantly decreased during COVID-19 PANDEMIC pandemics compared to before (p<0.0001). Although the COVID-19 Pandemic slightly reduced the intake of healthy meals and deterred participants from consuming unhealthy food, this this may have led to individual weight loss.
Conclusion. In general, there was a negative impact on, lifestyle like diet, sleep and mental health was observed. A detailed understanding of these factors can help to develop interventions to mitigate the harmful lifestyle-related etiquette that has manifested during COVID-19 Pandemic.
Nursing care for the transgender population in primary health care: an integrative review
Authors: Carneiro Chagas Manoella Alves , Dos Santos Adriano Maia , Neves de Jesus Naila 
Published: March 2023

Objective. To describe the care provided to the transgender population by nursing in Primary Health Care (PHC).
Methods. Integrative literature review performed in the Virtual Health Library (VHL), Medline/PubMed and Web of Science (WoS) databases without a pre-established time frame, using the descriptors “transgender persons”, “gender identity”, “nursing care” and “primary health care”.
Results. Eleven articles published between 2008-2021 were included. They were categorized as follows: Embracement and healthcare; Implementation of Public Health Policies; Weaknesses in academic training; Barriers between theory and practice. The articles showed a limited scenario of nursing care for the transgender population. The scarcity of research focused on this theme is an important sign of how care has been incipient or even non-existent in the context of PHC.
Conclusion. Structural and interpersonal stigmas materialized in discriminatory and prejudiced practices perpetrated by managers, professionals and health institutions constitute the greatest challenges to be overcome for comprehensive, equitable and humanized care provided to the transgender population by nursing
Change in the spectrum of detected mutations in the <I>DMD</I> gene depending on the methodological capabilities of the laboratory
Authors: Zinina E. V. , Bulakh M. V. , Ryzhkova O. P. , Shchagina O. A. , Polyakov A. V. 
Published: March 2023

Background. Duchenne muscular dystrophy (DMD) is a severe, progressive form of muscular dystrophy that occurs in children between one and three years of age. The disease is mainly characterized by weakness of the proximal muscles, which leads to difficulty in movement, and ultimately to complete disability. Becker muscular dystrophy (BMD) is a milder allelic form of the disorder characterized by late onset and slow progression. The cause of the development of DMD/BMD is mutations in the DMD gene, leading to a deficiency in the production of various isoforms of the dystrophin protein family. The most common mutations in case of DMD/BMD are gross deletions (55–65 %) and duplications (6–11 %) of one or several exons The remaining cases of DMD/BMD are due to small mutations (approximately 20–30 %). Depending on the methodological capabilities of the laboratory, the idea of the spectrum of mutations in the DMD gene changed, which is important in genetic counseling of patients and planning the therapy available today.Aim. To analyze the spectrum of mutations in the DMD gene, including three time slices, depending on the methodological capabilities of the laboratory.Materials and methods. We analyzed the spectrum of mutations in the DMD gene for a sample of 2957 patients admitted to the laboratory of DNA diagnostics of the Research Centre for Medical Genetics with a referral diagnosis of DMD/BMD. Depending on the time of treatment and the capabilities of the laboratory, patients were divided into three groups: 2008–2015, 2016–2018, 2019–2022.Results. As a result of the study, the full range of mutations in the DMD gene was analyzed over three-time intervals, which makes it possible to get an idea of the distribution of mutation types in the sample among Russian patients. Regardless of the methodological capabilities of the laboratory, the spectrum of mutations in the DMD gene remains biased relative to world data. At the moment, there is a significant decrease in the proportion of extended deletions (50.7–59.6 %), while the proportion of extended duplications (11.8–17.2 %) and small mutations (23.2–35.0 %) increased. We assume that the main reason for such features of the spectrum is ethnic and population differences.Conclusion. Duchenne/Becker muscular dystrophy (DMD/BMD) is the most common form of muscular dystrophy, accounting for more than 50 % of all cases. Determination of the spectrum of mutations provides an understanding of their frequencies, which in the future may help patients in the appointment of therapy specific to a particular type of mutation.
Aykırı Kültür (Kitap İncelemesi)
Authors: KARAL Sedat 
Published: March 2023

Aykırı Kültür (Kitap İncelemesi)
Birmingham Üniversitesi bünyesinde 1964 yılında kurulan, ağırlıklı olarak kültürel çalışmalara odaklanan ve bunu yaparken de anti-elitist bir tavır takınan Çağdaş Kültürel Çalışmalar Merkezi’nin ya da diğer adıyla Birmingham Okulu’nun mezunlarından biri olan Paul E. Willis’in “Aykırı Kültür” (2022) adlı kitabı, Gökben Demirbaş tarafından Türkçeye kazandırılarak Ayrıntı Yayınları’nca yayımlandı. 1960’lı yılların sonu ve 1970’li yılların başlarında İngiltere’de yapılmış iki farklı etnografik çalışmanın bir araya getirilmesinden oluşan kitap, “motorcular”ın ve “hippiler”in dünyasına odaklanmaktadır. Bu nedenle kitap, farklı kültürel dünyalardan elde edilen verileri yorumlayarak analiz eden iki ana bölümden ve ayrıca çeşitli gruplar hakkında etnografik araştırma yapmak isteyenler için bir nevi kılavuz denilebilecek teorik ek bölümden oluşmaktadır. Bu değerlendirme yazısında ilk olarak motorcuların sonrasında ise hippilerin, diğer bir deyişle iki farklı kültürel dünyanın yazar tarafından nasıl sorunsallaştırılıp ele alındığı kitapta sunulan çeşitli gözlemlerden hareketle incelenecek, daha sonra kitabın zayıf ve güçlü yanları üzerinde durulacaktır.
Sistema de Creencias Familiares e Infidelidad en Parejas Convivientes de Tarapoto
Authors: Rojas Ramón Ruth Nora , Vecco Giove Melissa Valentina 
Published: March 2023

El presente artículo analiza y explica el vínculo entre el sistema de creencias familiares y la infidelidad en parejas convivientes que reciben asistencia en una institución pública de Tarapoto - Perú. El objetivo del estudio fue explorar y dar a conocer la influencia de los sistemas de creencias familiares en las conductas de infidelidad. Este estudio se realizó empleando el método cualitativo. El análisis de resultados de las entrevistas individuales a profundidad a ambos miembros de la pareja estuvo enmarcado en un enfoque sistémico.
De la investigación se obtuvo que existen similitudes entre los miembros de la pareja respecto a sus creencias, lo cual genera una mayor tolerancia hacia la conducta infiel masculina. Es decir, que hay afinidad en las creencias de varón y mujer sobre los roles de género, el amor, la familia, las diferencias biológicas entre varones y mujeres, entre otros. Las creencias personales, familiares y sociales se encuentran arraigadas y difícilmente son cuestionadas, sino que tienden a ser reforzadas. En tal sentido, la investigación permitió aproximarse a una mayor comprensión de la relación entre el sistema de creencias y la conducta infiel, tanto en varones como mujeres. El presente estudio será de ayuda para conocer en profundidad esta realidad psicosocial, que afecta el bienestar psicológico de las personas.
A prospective study of effect of delayed cord clamping in term babies as well as in preterm babies
Authors: Priya Shaloo , Biswas Arati , Rani Saba 
Published: March 2023

Background: Delayed cord clamping (DCC) is lengthening the time between delivery of newborn and the clamping of their umbilical cord. It is usually performed 25 seconds to 5 minutes after birth, which increases the newborn’s iron storage, vital for healthy brain development.
Methods: This prospective observational study was conducted on 100 late preterm and term newborns delivered in the obstetrics and gynaecology department of Calcutta national medical college and hospital, Kolkata over a period of one and half years (March 2019 to August 2020). The umbilical cord was clamped between 60 to 90 seconds after birth of baby. Babies’ weight measurement and blood investigations (Haemoglobin (Hb) level, total serum bilirubin (TSB) and serum ferritin) were performed at birth, after 24 hours of birth and at 6 weeks of age.
Results: In this study after DCC, there is significant increase in Serum Ferritin levels after 24 hours and 6 weeks as compared to the birth values. As far as the values of TSB and hemoglobin is concerned, the values first showed increment after 24 hours and then decreased at 6 weeks, which is statistically significant (p=0.001). Birth weight which first decreased after 24 hours, increased at 6 weeks. None of the babies needed blood transfusion during the study period. Out of 100 cases, 9 were admitted in NICU and required phototherapy which was not directly associated with umbilical cord clamping time or bilirubin values at birth.
Conclusions: Based on the results of this study, we conclude that newborns with DCC had statistically significant higher levels of Hb and ferritin after birth. This may ensure better iron status throughout infancy along with reduced need of blood transfusion and its related adversities. Delaying cord clamping seems to be beneficial in late preterm and term neonates without causing additional morbidities in the first 6 weeks of life.