bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Humanitarian Mission by Jewish Joint Distribution Committee in Hungary (1914-1921)
Authors: Shevchuk Oleksandr , Siekunova Yuliia 
Published: May 2023

The purpose of the research paper is coverage of the process of deployment of the Jewish Joint Distribution Committee’s humanitarian mission in Hungary, determination of its scope and addressees, evaluation of aid results.
The scientific novelty is lies in the fact that for the first time the JDC’s humanitarian mission is shown in the Hungarian territories – during the First World War, as part of Austria-Hungary, after – as an independent State. The JDC’s role in helping both Hungarian Jews and refugees from the territories who suffered from hostilities is shown. The volumes of assistance, its forms and the main addressers of its receipt are disclosed.
Conclusions. In spite of insurmountable difficulties during World War I and in the post-War years that followed it; in spite of the lack of unity and of many internal differences; in spite of negative attitudes from various governments – in spite of all these obstacles, American Jewry was able not only to deliver general organized relief to the starving European Jews (including Hungarian Jews), but also to assist in the organization of the machinery for the transmission of private relief. Indeed, on November 13, 1919, Dr. Bogen wrote in his report: “The most essential factor in this rehabilitation is the establishment of the necessary means to transmit the relief so generously proffered by American Jewry, the organization of the transmission system”.
JDC for the first time had brought together in the common task of mercy American Jews of all shades of opinion. The experience of these years had developed an organization and had recruited dedicated personnel. A small but adaptable staff of diverse background and experience brought together a corps of experts ready to take on additional assignments. A network of affiliated Jewish organizations was prepared to assume responsibility for reconstruction, but was also available in the event of unexpected crisis.
Aids for the Jews of Hungary was, though small, but very tangible. Local Jews, as well as refugees from neighboring territories (especially Galicia) received much-needed support. Participation in the program of the European Children’s Fund saved tens of thousands of children and their families from death. At the same time, this program had its continuation in the future. All this created the basis for the transition to the stage of reconstruction, which, if possible, we will highlight in further studies.
Foreign Consulates in Odesa (1920s – 1930s)
Authors: Vovchuk Liudmyla 
Published: May 2023

The purpose of the research paper is to highlight the history of repatriation missions and consular institutions of Poland, Albania, Germany, Italy, Turkey, Japan and Spain in Odesa during 1922-1938, analysis of the main areas of activity within the consular district and the consular staff’s characteristics.
The scientific novelty. The general picture of the foreign diplomatic presence in Odesa, represented by the repatriation missions of Turkey, Albania and Poland, as well as five consulates, has been reconstructed. Their personnel composition and key areas of activity are shown.
Conclusions. With the creation of Soviet Ukraine, Odesa continued to remain a strategically important city for both European and Asian countries, which, having restored diplomatic and consular relations with the USSR, opened their consulates here. During the 1920s and 1930s, the repatriation missions of Poland, Albania, and Turkey operated in the city first (during 1922-1925), and later the consular offices of three European countries – Germany, Italy, Spain, and two Asian countries – Turkey and Japan. The foreign consular institutions’ diplomatic staff consisted exclusively of representatives of the countries they represented and were career diplomats. In turn, among the representatives of the administrative and technical staff were citizens of these countries and Soviet Ukraine, and the service staff consisted with local residents.
Since its establishment, foreign consular representatives have contributed to the development of trade, economic, cultural and scientific relations of their countries with the UkrSSR. Important spheres of consulates’ activity were protection of the citizens’ interests of their countries, organization of material assistance for them and promotion of their departure to their homeland. In the process of gathering information about the socio-political situation in the USSR, the consuls recorded the unfolding of the Holodomor, pointing out its culprits, noted the negative consequences of collectivization and industrialization, etc.
But, despite the constantly emphasized friendship in relations between the USSR and the countries listed above, their consulates and employees found themselves under the Soviet special services close supervision, which considered any consulates representatives’ actions as espionage. In order to be fully effective, the special services recruited representatives from both consulate employees and persons who were in contact with the consul. And after the consulates were closed, they began the process of “cleaning” them. In 1937-1938, the USSR’s relations with Italy, Germany, Turkey, Japan, and Spain became strained, which led to the closure of the consular network in Odesa.
Development of constrictional microchannels and the recurrent neural network in single-cell protein analysis
Authors: Zhang Ting , Chen Xiao , Chen Deyong , Wang Junbo , Chen Jian 
Published: May 2023

Introduction: As the golden approach of single-cell analysis, fluorescent flow cytometry can estimate single-cell proteins with high throughputs, which, however, cannot translate fluorescent intensities into protein numbers.Methods: This study reported a fluorescent flow cytometry based on constrictional microchannels for quantitative measurements of single-cell fluorescent levels and the recurrent neural network for data analysis of fluorescent profiles for high-accuracy cell-type classification.Results: As a demonstration, fluorescent profiles (e.g., FITC labeled β-actin antibody, PE labeled EpCAM antibody and PerCP labeled β-tubulin antibody) of individual A549 and CAL 27 cells were firstly measured and translated into protein numbers of 0.56 ± 0.43 × 104, 1.78 ± 1.06 × 106 and 8.11 ± 4.89 × 104 of A549 cells (ncell = 10232), and 3.47 ± 2.45 × 104, 2.65 ± 1.19 × 106 and 8.61 ± 5.25 × 104 of CAL 27 cells (ncell = 16376) based on the equivalent model of the constrictional microchannel. Then, the feedforward neural network was used to process these single-cell protein expressions, producing a classification accuracy of 92.0% for A549 vs. CAL 27 cells. In order to further increase the classification accuracies, as a key subtype of the recurrent neural network, the long short-term memory (LSTM) neural network was adopted to process fluorescent pulses sampled in constrictional microchannels directly, producing a classification accuracy of 95.5% for A549 vs. CAL 27 cells after optimization.Discussion: This fluorescent flow cytometry based on constrictional microchannels and recurrent neural network can function as an enabling tool of single-cell analysis and contribute to the development of quantitative cell biology.
pH-sensitive charge-conversion cinnamaldehyde polymeric prodrug micelles for effective targeted chemotherapy of osteosarcoma in vitro
Authors: Deng Jiapeng , Liu Su , Li Guoqing , Zheng Yien , Zhang Weifei , Lin Jianjing , Yu Fei , Weng Jian , Liu Peng , Zeng Hui 
Published: May 2023

Introduction: Chemotherapy is a common strategy for the treatment of osteosarcoma. However, its therapeutic efficacy is not ideal due to the low targeting, lowbioavailability, and high toxicity of chemotherapy drugs. Nanoparticles can improve the residence time of drugs at tumor sites through targeted delivery. This new technology can reduce the risk to patients and improve survival rates. To achieve this goal, we developed a pHsensitive charge-conversion polymeric micelle [mPEG-b-P(C7-co-CA) micelles] for osteosarcoma-targeted delivery of cinnamaldehyde (CA).Methods: First, an amphiphilic cinnamaldehyde polymeric prodrug [mPEG-b-P(C7-co-CA)] was synthesized through Reversible Addition-Fragmentation Chain Transfer Polymerization (RAFT) polymerization and post-modification, and self-assembled into mPEG-b-P(C7-co-CA) micelles in an aqueous solution. The physical properties of mPEG-b-P(C7-co-CA) micelles, such as critical micelle concentration (CMC), size, appearance, and Zeta potential were characterized. The CA release curve of mPEG-b-P(C7-co-CA) micelles at pH 7.4, 6.5 and 4.0 was studied by dialysis method, then the targeting ability of mPEG-b-P(C7-co-CA) micelles to osteosarcoma 143B cells in acidic environment (pH 6.5) was explored by cellular uptakeassay. The antitumor effect of mPEG-b-P(C7-co-CA) micelles on 143B cells in vitro was studied by MTT method, and the level of reactive oxygen species (ROS) in 143B cells after mPEG-b-P(C7-co-CA) micelles treatment was detected. Finally, the effects of mPEG-b-P(C7-co-CA) micelles on the apoptosis of 143B cells were detected by flow cytometry and TUNEL assay.Results: An amphiphilic cinnamaldehyde polymeric prodrug [mPEG-b-P(C7-co-CA)] was successfully synthesized and self-assembled into spheric micelles with a diameter of 227 nm. The CMC value of mPEG-b-P(C7-co-CA) micelles was 25.2 mg/L, and it showed a pH dependent release behavior of CA. mPEG-b-P(C7-co-CA) micelles can achieve chargeconversion from a neutral to a positive charge with decreasing pHs. This charge-conversion property allows mPEG-b-P(C7-co-CA) micelles to achieve 143B cell targeting at pH 6.5. In addition, mPEG-b-P(C7-co-CA) micelles present high antitumor efficacy and intracellular ROS generation at pH 6.5 which can induce 143B cell apoptosis.Discussion: mPEG-b-P(C7-co-CA) micelles can achieve osteosarcoma targeting effectively and enhance the anti-osteosarcoma effect of cinnamaldehyde in vitro. This research provides a promising drug delivery system for clinical application and tumor treatment.
Association between ACE I/D genetic polymorphism and the severity of coronary artery disease in Vietnamese patients with acute myocardial infarction
Authors: Tran Duy Cong , Le Linh Hoang Gia , Thai Truc Thanh , Hoang Sy Van , Do Minh Duc , Truong Binh Quang 
Published: May 2023

BackgroundThe severity of coronary artery disease is a prognostic factor for major adverse cardiovascular events in patients diagnosed with acute myocardial infarction. ACE I/D polymorphism is one of the genetic factors that may affect the severity of coronary artery disease. This study aimed to investigate the association between ACE I/D genotypes and the severity of coronary artery disease in patients with acute myocardial infarction.Materials and methodsA single-center, prospective, observational study was conducted at the Department of Cardiology and Department of Interventional Cardiology, Cho Ray Hospital, Ho Chi Minh City, Vietnam from January 2020 to June 2021. All participants diagnosed with acute myocardial infarction underwent contrast-enhanced coronary angiography. The severity of coronary artery disease was determined by Gensini score. ACE I/D genotypes were identified in all subjects by using the polymerase chain reaction method.ResultsA total of 522 patients diagnosed with first acute myocardial infarction were recruited. The patients' median Gensini score was 34.3. The II, ID, and DD genotype rates of ACE I/D polymorphism were 48.9%, 36.4%, and 14.7%, respectively. After adjusting for confounding factors, multivariable linear regression analysis showed that the ACE DD genotype was independently associated with a higher Gensini score compared with the II or ID genotypes.ConclusionThe DD genotype of the ACE I/D polymorphism was associated with the severity of coronary artery disease in Vietnamese patients diagnosed with first acute myocardial infarction.
Metabolomics profile and 10-year atherosclerotic cardiovascular disease (ASCVD) risk score
Authors: Dehghanbanadaki Hojat , Dodangeh Salimeh , Parhizkar Roudsari Peyvand , Hosseinkhani Shaghayegh , Khashayar Pouria , Noorchenarboo Mohammad , Rezaei Negar , Dilmaghani-Marand Arezou , Yoosefi Moein , Arjmand Babak , Khalagi Kazem , Najjar Niloufar , Kakaei Ardeshir , Bandarian Fatemeh , Aghaei Meybodi Hamid , Larijani Bagher , Razi Farideh 
Published: May 2023

BackgroundThe intermediate metabolites associated with the development of atherosclerotic cardiovascular disease (ASCVD) remain largely unknown. Thus, we conducted a large panel of metabolomics profiling to identify the new candidate metabolites that were associated with 10-year ASCVD risk.MethodsThirty acylcarnitines and twenty amino acids were measured in the fasting plasma of 1,102 randomly selected individuals using a targeted FIA-MS/MS approach. The 10-year ASCVD risk score was calculated based on 2013 ACC/AHA guidelines. Accordingly, the subjects were stratified into four groups: low-risk (n = 620), borderline-risk (n = 110), intermediate-risk (n = 225), and high-risk (n = 147). 10 factors comprising collinear metabolites were extracted from principal component analysis.ResultsC4DC, C8:1, C16OH, citrulline, histidine, alanine, threonine, glycine, glutamine, tryptophan, phenylalanine, glutamic acid, arginine, and aspartic acid were significantly associated with the 10-year ASCVD risk score (p-values ≤ 0.044). The high-risk group had higher odds of factor 1 (12 long-chain acylcarnitines, OR = 1.103), factor 2 (5 medium-chain acylcarnitines, OR = 1.063), factor 3 (methionine, leucine, valine, tryptophan, tyrosine, phenylalanine, OR = 1.074), factor 5 (6 short-chain acylcarnitines, OR = 1.205), factor 6 (5 short-chain acylcarnitines, OR = 1.229), factor 7 (alanine, proline, OR = 1.343), factor 8 (C18:2OH, glutamic acid, aspartic acid, OR = 1.188), and factor 10 (ornithine, citrulline, OR = 1.570) compared to the low-risk ones; the odds of factor 9 (glycine, serine, threonine, OR = 0.741), however, were lower in the high-risk group. “D-glutamine and D-glutamate metabolism”, “phenylalanine, tyrosine, and tryptophan biosynthesis”, and “valine, leucine, and isoleucine biosynthesis” were metabolic pathways having the highest association with borderline/intermediate/high ASCVD events, respectively.ConclusionsAbundant metabolites were found to be associated with ASCVD events in this study. Utilization of this metabolic panel could be a promising strategy for early detection and prevention of ASCVD events.
Early atrial remodeling predicts the risk of cardiovascular events in patients with metabolic syndrome: a retrospective cohort study
Authors: Wali Rohbaiz , Wang Xinying , Li Chenglin , Yang Heng , Liu Fei , Sama Salah D. , Bai Lan , Lee Sharen , Hidru Tesfaldet H. , Yang Xiaolei , Xia Yunlong 
Published: May 2023

BackgroundThis study aims to assess the prevalence of atrial cardiomyopathy (ACM) in patients with new-onset metabolic syndrome (MetS) and investigate whether ACM could be a predictor of hospital admission for cardiovascular (CV) events.MethodsPatients with MetS who were free of clinically proven atrial fibrillation and other CV diseases (CVDs) at baseline were included in the present study. The prevalence of ACM was compared between MetS patients with and without left ventricular hypertrophy (LVH). The time to first hospital admission for a CV event between subgroups was assessed using the Cox proportional hazard model.ResultsA total of 15,528 MetS patients were included in the final analysis. Overall, LVH patients accounted for 25.6% of all newly diagnosed MetS patients. ACM occurred in 52.9% of the cohort and involved 74.8% of LVH patients. Interestingly, a significant percentage of ACM patients (45.4%) experienced MetS without LVH. After 33.2 ± 20.6 months of follow-up, 7,468 (48.1%) patients had a history of readmission due to CV events. Multivariable Cox regression analysis revealed that ACM was associated with an increased risk of admission for CVDs in the MetS patients with LVH [hazard ratio (HR), 1.29; 95% confidence interval (CI), 1.142–1.458; P &lt; 0.001]. Likewise, ACM was found to be independently associated with hospital readmission due to CVD-related events in MetS patients without LVH (HR, 1.175; 95% CI, 1.105–1.250; P &lt; 0.001).ConclusionACM is a marker of early myocardial remodeling and predicts hospitalization for CV events in patients with MetS.
Cardiogenic shock due to reverse takotsubo syndrome triggered by multiple sclerosis brainstem lesions: a case report and mini review
Authors: Brandner Joas , Lu Henri , Muller Olivier , Eskioglou Elissavet , Chiche Jean-Daniel , Antiochos Panagiotis , Chocron Yaniv 
Published: May 2023

BackgroundTakotsubo syndrome (TTS) is mainly characterized by chest pain, left ventricular dysfunction, ST-segment deviation on electrocardiogram (ECG) and elevated troponins in the absence of obstructive coronary artery disease. Diagnostic features include left ventricular systolic dysfunction shown on transthoracic echocardiography (TTE) with wall motion abnormalities, generally with the typical “apical ballooning” pattern. In very rare cases, it involves a reverse form which is characterized by basal and mid-ventricular severe hypokinesia or akinesia, and sparing of the apex. TTS is known to be triggered by emotional or physical stressors. Recently, multiple sclerosis (MS) has been described as a potential trigger of TTS, especially when lesions are located in the brainstem.Case summaryWe herein report the case of a 26-year-old woman who developed cardiogenic shock due to reverse TTS in the setting of MS. After being admitted for suspected MS, the patient presented with rapidly deteriorating clinical condition, with acute pulmonary oedema and hemodynamic collapse, requiring mechanical ventilation and aminergic support. TTE found a severely reduced left ventricular ejection fraction (LVEF) of 20%, consistent with reverse TTS (basal and mid ventricular akinesia, apical hyperkinesia). Cardiac magnetic resonance imaging (MRI) performed 4 days later showed myocardial oedema in the mid and basal segments on T2-weighted imaging, with partial recovery of LVEF (46%), confirmed the diagnosis of TTS. In the meantime, the suspicion of MS was also confirmed, based on cerebral MRI and cerebral spinal fluid analyses, with a final diagnosis of reverse TTS induced by MS. High-dose intravenous corticotherapy was initiated. Subsequent evolution was marked by rapid clinical improvement, as well as normalization of LVEF and segmental wall-motion abnormalities.ConclusionOur case is an example of the brain-heart relationship: it shows how neurologic inflammatory diseases can trigger a cardiogenic shock due to TTS, with potentially serious outcomes. It sheds light on the reverse form, which, although rare, has already been described in the setting of acute neurologic disorders. Only a handful of case reports have highlighted MS as a trigger of reverse TTS. Finally, through an updated systematic review, we highlight the unique features of patients with reversed TTS triggered by MS.
Risk of diabetic retinopathy and retinal neurodegeneration in individuals with type 2 diabetes: Beichen Eye Study
Authors: Yang Zhengwei , Liu Qingyan , Wen Dejia , Yu Zihao , Zheng Chuanzhen , Gao Fei , Chen Chen , Hu Liying , Shi Yu , Zhu Xiuqing , Liu Juping , Shao Yan , Li Xiaorong 
Published: May 2023

ObjectiveOur aim was to evaluate associations of different risk factors with odds of diabetic retinopathy (DR) diagnosis and retinal neurodegeneration represented by macular ganglion cell-inner plexiform layer (mGCIPL).MethodsThis cross-sectional study analyzed data from individuals aged over 50 years examined between June 2020 and February 2022 in the community-based Beichen Eye Study on ocular diseases. Baseline characteristics included demographic data, cardiometabolic risk factors, laboratory findings, and medications at enrollment. Retinal thickness in both eyes of all participants was measured automatically via optical coherence tomography. Risk factors associated with DR status were investigated using multivariable logistic regression. Multivariable linear regression analysis was performed to explore associations of potential risk factors with mGCIPL thickness.ResultsAmong the 5037 included participants with a mean (standard deviation, SD) age of 62.6 (6.7) years (3258 women [64.6%]), 4018 (79.8%) were control individuals, 835 (16.6%) were diabetic individuals with no DR, and 184 (3.7%) were diabetic individuals with DR. The risk factors significantly associated with DR status were family history of diabetes (odds ratio [OR], 4.09 [95% CI, 2.44-6.85]), fasting plasma glucose (OR, 5.88 [95% CI, 4.66-7.43]), and statins (OR, 2.13 [95% CI, 1.03-4.43]) relative to the control individuals. Compared with the no DR, diabetes duration (OR, 1.17 [95% CI, 1.13-1.22]), hypertension (OR, 1.60 [95% CI, 1.26-2.45]), and glycated hemoglobin A1C (HbA1c) (OR, 1.27 [95% CI, 1.00-1.59]) were significantly correlated with DR status. Furthermore, age (adjusted β = -0.19 [95% CI, -0.25 to -0.13] μm; P &lt; 0.001), cardiovascular events (adjusted β = -0.95 [95% CI, -1.78 to -0.12] μm; P = 0.03), and axial length (adjusted β = -0.82 [95% CI, -1.29 to -0.35] μm; P = 0.001) were associated with mGCIPL thinning in diabetic individuals with no DR.ConclusionMultiple risk factors were associated with higher odds of DR development and lower mGCIPL thickness in our study. Risk factors affecting DR status varied among the different study populations. Age, cardiovascular events, and axial length were identified as potential risk factors for consideration in relation to retinal neurodegeneration in diabetic patients.