bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quality and safety of natto fermented with Bacillus subtilis BJ3-2 using kidney beans from Guizhou
Authors: Fu Jingyi , Wu Yongjun , Yang Yi , Zhang Wen , Zhang Shilong , Ge Pingzhen , Wen Anyan , Wu Qifeng , Zengx Haiying , Qin Likang 
Published: January 2025

Abstract
With the continued development of the kidney bean industry and increased kidney bean production, processing methods need to be developed and optimized for kidney beans. This study focused on the nutritional qualities of seven varieties of raw materials of Guizhou kidney bean and the characteristic and safety factors of kidney bean natto (KBN), including amino acid nitrogen, mucus yield, NK activity, and biogenic amines. The kidney beans demonstrated good adaptability to natto processing. After fermentation, the average protein content of the seven kidney beans increased by about 3.37 g/100. Among the varieties, YuQiuDou (YQD, P520522025) demonstrated the best adaptability to fermentation. The nutritional composition of YQD kidney beans was as follows: total starch (53.55 g/100 g), protein (23.84 g/100 g), resistant starch (27.00 g/100 g), and α-AI (6.39 U/g). The mucilage yield of YQD natto was determined to be 20.57%, while the NK activity exhibited by YQD natto was measured at 0.2992 ± 0.002 TAME. The biogenic amines detected in KBNs were 7.62–33.92 mg/kg (lower than the US FDA limit of ≤ 50 mg/kg), and spermine was predominant. This study provides guidance and a reference for the future development of kidney bean products and the selection of raw materials.
Exploring the deciphering properties of Cyamopsis Tetragonoloba: its food application, feasibility, and future aspects
Authors: Rani Ritu , Kaushik Deepika , Babagil Gülçin Emel , Proestos Charalampos , Brennan Charles , Oz Fatih , Kumar Mukul 
Published: January 2025

Abstract
Cyamopsis tetragonoloba belongs to the Fabaceae family and is an erect, drought-resistant, coarse-textured, annual legume. This species serves as a valuable source of nutrition for both livestock and humans. The purpose of this review is to explore the nutritional profile of C. tetragonoloba, highlighting its richness in dietary fiber, proteins, and essential minerals, alongside its bioactive compounds, such as flavonoids and polysaccharides, which demonstrate antioxidant, anticancer, and antidiabetic properties and its applications. The potential of C. tetragonoloba in developing biodegradable packaging materials is also explored, highlighting its ability to enhance mechanical properties and food product storage stability, making it a viable alternative to petrochemical-based plastics. Additionally, this review addresses C. tetragonoloba cultivation’s environmental impact and sustainability, emphasizing the importance of efficient byproduct Valorization, pharma industry and its role in circular economy practices. Key challenges and future research directions include improving processing technologies, exploring novel applications for C. tetragonoloba -based materials, and enhancing C. tetragonoloba cultivation and utilization for environmental and economic sustainability.
Preliminary study on the correlation between enzyme activity assays and substrate preferences of microbial transglutaminase
Authors: Zheng Xinyue , Luo Wenjie , Wang Mingfeng , Chen Xing , Liu Jing , Wang Lei , Zhang Wei , Hu Weiyao , Dong Gaofeng , Pan Hongyang , Wang Zhaojun , Chen Qiuming 
Published: January 2025

Abstract
The transglutaminase (TGase) derived from microorganisms, known for its exceptional protein cross-linking properties, holds significant application potential across various fields. In order to meet market demands such as temperature preferences, catalytic capabilities, selectivity, and the exploration of novel TGases, challenges have arisen for the development of TGases. In this study, we conducted enzymatic activity assays on TGases from Shouchella clausii (strain KSM-K16) (Alkalihalobacillus clausii) and Couchioplanes caeruleus, randomly selected from the TrEMBL database in UniProt. We also simulated the reaction process of these assays and provided interpretations of the results. Subsequently, we examined their cross-linking abilities with protein substrates bovine serum albumin (BSA) and Soy protein isolate (SPI). By validating with commercial TGase, we identified the correlation between the two commonly used enzymatic activity assay methods for TGase and the substrate preference of TGase. This correlation will aid in the specific modification of TGase.
Local income inequality and product variety: empirical evidence
Authors: Pennerstorfer Dieter , Schindler Nora , Yontcheva Biliana 
Published: January 2025

Abstract
This article investigates the relationship between local income inequality and firms’ location and product choices. Using detailed information on income at a regionally disaggregated level and individual data on Austrian restaurants, we show that product variety crucially depends on the distribution (in addition to the level) of income. Local markets with higher income inequality are characterized by a larger number of firms, offering a wider range of products and less common product variants. These findings suggest that local demand is substantially influenced by the heterogeneity of consumers’ income endowments, resulting in large differences in product variety.
Insights into the fine-scale habitat use of Eurasian Water Shrew (Neomys fodiens) using radio tracking and LiDAR
Authors: van der Putten Towi A W , Verhees Joris J F , Koma Zsofia , van Hoof Paul H , Heijkers Dirk , de Boer Willem F , Esser Helen J , Hoogerwerf Gert , Lemmers Pim 
Published: January 2025

Abstract
The Eurasian Water Shrew (Neomys fodiens) is one of the largest shrew (Soricidae) species in Eurasia. In Western Europe, this semiaquatic species often occurs in riparian and marshland habitats that have a high degree of naturalness, but is being threatened by habitat degradation and other anthropogenic factors. The species mostly occurs in low abundance and is elusive. Therefore, understanding its habitat use is challenging, yet imperative for establishing species-specific conservation measures. Technological developments in radio tracking and high-resolution remote sensing such as Light Detection And Ranging (LiDAR) now enable the quantification of ecological niches and provide insight into habitat requirements for a species. Here, we combined radio tracking and LiDAR to quantify habitat use by Eurasian water shrews. Alongside a lowland brook in the Netherlands, 20 individuals were tracked between September and October 2022, resulting in 332 unique locations of Eurasian water shrews. For each of these locations, 11 LiDAR-derived variables were calculated and subsequently analyzed in a species distribution model (SDM). The SDM yielded a model with a high accuracy (predictive performance AUC = 0.93). The variable of highest importance was dense and relatively short vegetation &lt;1 m, which had a positive effect on Eurasian Water Shrew occurrence. Open areas seem to be avoided. Vegetation of heights between 1 and 15 m were found to be less important for the occurrence. The probability of occurrence decreased with increasing distance to water, indicating that the species occurs in the proximity of water, although vegetation-related variables were more important. The obtained detailed knowledge of fine-scale habitat use can be used to improve habitat conservation, restoration, and management for the species. Combining radiotelemetry data with LiDAR data is a promising approach to identifying species–habitat relationships of elusive species such as the Eurasian Water Shrew.
Cats in farms: ranging behavior of the Fishing Cat (Prionailurus viverrinus) in a human-dominated landscape
Authors: Mishra Rama , Lamichhane Babu Ram , Leirs Herwig , Subedi Naresh , Adhikari Sabin , Acharya Hem Raj , de Iongh Hans H 
Published: January 2025

Abstract
Home range studies provide valuable insights into animal ecology and behavior, informing conservation efforts and management strategies. Although the Fishing Cat (Prionailurus viverrinus) is a globally threatened habitat specialist species, only a few studies have been conducted on their home range and social organization, especially in response to human influence. In this study, we tracked 11 fishing cats with satellite GPS collars to investigate their home range size and habitat use in and around Koshi Tappu Wildlife Reserve, Nepal. The minimum convex polygon (MCP) and autocorrelation-informed kernel density estimation (AKDE) were used to estimate home range sizes of the fishing cats. Altogether 2,303 locations were obtained from 11 collared cats. The average home ranges of fishing cats (n = 8) with 95% MCP and 95% AKDE were 29.12 ± SD 16.89 km2 and 39.88 ± 26.16 km2, respectively. Home range (95% AKDE) of adult females (21.72 ± SD 16.39 km2, n = 4) was significantly smaller compared to males (58.03 ± SD 21.19 km2, n = 4). Sex-specific social organization with a single male overlapping with multiple nonoverlapping adult females was consistent with home range behaviors of other carnivores. The highest number of locations of collared fishing cats were in tall grasslands, whereas they highly preferred wetlands. A large part (over one-third) of fishing cat home ranges covers human-dominated areas such as fishponds, agriculture, and settlements encompassing various threats to fishing cats including persecution, road kills, and dog attacks. To ensure long-term survival of these cats amid habitat alteration and human–wildlife conflict, we recommend Fishing Cat conservation activities focusing on raising awareness, especially in human-dominated landscapes.
Repairing the mitral valve without touching the mitral valve—a novel technique
Authors: Sitaranjan Daniel , Kumar Ujjawal , Al-Zubaidi Fadi , Smith Harry , Kumar Sambhavi S , Large Stephen 
Published: January 2025

Abstract
A 44-year-old gentleman presented with severe ischemic cardiomyopathy and mitral regurgitation post-inferior myocardial infarction. Echocardiography and magnetic resonance imaging revealed a dilated left ventricle with a large left ventricular aneurysm (9.3 × 9.5 cm) and associated thrombus. Severe mitral regurgitation due to leaflet tethering and a left ventricular ejection fraction (LVEF) of 25% were also seen. The patient underwent successful aneurysmectomy with patch repair and papillary muscle approximation. Following initial weaning from cardiopulmonary bypass, 6 days of postoperative temporary veno-arterial extracorporeal membrane oxygenation support were required. The patient was subsequently discharged on postoperative day sixteen with improved cardiac function (LVEF of 45%) and trace residual mitral regurgitation, highlighting the efficacy of geometric restoration in addressing such mitral regurgitation, avoiding conventional intervention on the mitral valve itself.
AGN energetics and lifetimes from remnant radio galaxies
Authors: Quici Benjamin , Turner Ross J , Seymour Nicholas , Hurley-Walker Natasha 
Published: January 2025

ABSTRACT
The energy coupling efficiency of active galactic nucleus (AGN) outbursts is known to vary significantly with factors including the jet kinetic power, duration of the outburst, and properties of the host galaxy group or cluster. As such, constraints on their jet power and lifetime functions are crucial to quantify the role of kinetic-mode AGN feedback on the evolution of galaxies since $z \sim 1$. In this work, we address this issue by measuring the energetics of a sample of 79 low-redshift (0.02 $\lt z \lt $ 0.2) remnant radio galaxies compiled from large-sky radio surveys – remnants uniquely probe the full duration of an AGN outburst. The jet kinetic power and outburst duration of each remnant are determined using the raise dynamical model based on the surface brightness distribution observed in multifrequency radio images. We compare the energetics constrained for this sample to those predicted for mock radio source populations – with various intrinsic functions for jet power and lifetime distributions – to correct for sample selection biases imposed on our sample. The intrinsic jet power and lifetime functions that yield a selection-biased mock population most similar to our observed sample are determined using Bayesian inference. Our analysis places robust constraints on assumed power-law indices for the intrinsic jet power and lifetime functions: $p(Q)\propto Q^{-1.49\pm 0.07}$ and $p(t_{\mathrm{on}})\propto t_{\mathrm{on}}^{-0.97\pm 0.12}$, respectively. We discuss the implications of these findings for feedback-regulated accretion and the self-regulating nature of jet activity. The methodology proposed in this work can be extended to active radio galaxies in future studies.
Rapid Mid-Infrared Spectral-Timing with JWST: I. GRS 1915+105 during a MIR–bright and X-ray–obscured state
Authors: Gandhi P , Borowski E S , Byrom J , Hynes R I , Maccarone T J , Shaw A W , Adegoke O K , Altamirano D , Baglio M C , Bhargava Y , Britt C T , Buckley D A H , Buisson D J K , Casella P , Segura N Castro , Charles P A , Corral-Santana J M , Dhillon V S , Fender R , Gúrpide A , Heinke C O , Igl A B , Knigge C , Markoff S , Mastroserio G , McCollough M L , Middleton M , Miller J M , Miller-Jones J C A , Motta S E , Paice J A , Pawar D D , Plotkin R M , Pradhan P , Ressler M E , Russell D M , Russell T D , Santos-Sanz P , Shahbaz T , Sivakoff G R , Steeghs D , Tetarenko A J , Tomsick J A , Vincentelli F M , George M , Gurwell M , Rao R 
Published: January 2025

Abstract
We present mid-infrared (MIR) spectral-timing measurements of the prototypical Galactic microquasar GRS 1915+105. The source was observed with the Mid-Infrared Instrument (MIRI) onboard JWST in June 2023 at a MIR luminosity LMIR ≈ 1036 erg s−1 exceeding past IR levels by about a factor of 10. In contrast, the X-ray flux is much fainter than the historical average, in the source’s now–persistent ‘obscured’ state. The MIRI low-resolution spectrum shows a plethora of emission lines, the strongest of which are consistent with recombination in the hydrogen Pfund (Pf) series and higher. Low amplitude (∼ 1%) but highly significant peak-to-peak photometric variability is found on timescales of ∼ 1,000 s. The brightest Pf (6–5) emission line lags the continuum. Though difficult to constrain accurately, this lag is commensurate with light-travel timescales across the outer accretion disc or with expected recombination timescales inferred from emission line diagnostics. Using the emission line as a bolometric indicator suggests a moderate (∼ 5–30 % Eddington) intrinsic accretion rate. Multiwavelength monitoring shows that JWST caught the source close in-time to unprecedentedly bright MIR and radio long-term flaring. Assuming a thermal bremsstrahlung origin for the MIRI continuum suggests an unsustainably high mass-loss rate during this time unless the wind remains bound, though other possible origins cannot be ruled out. PAH features previously detected with Spitzer are now less clear in the MIRI data, arguing for possible destruction of dust in the interim. These results provide a preview of new parameter space for exploring MIR spectral-timing in XRBs and other variable cosmic sources on rapid timescales.
Incidence of Acute Kidney Injury in Relapsed and Refractory Multiple Myeloma treated with Teclistamab versus CAR T-cells
Authors: Charkviani Mariam , Brochero Maria Jose Vargas , Mohan Arjunmohan , Vaughan Lisa E , Sandahl Tyler B , De Menezes Silva Corrae Andre , Lin Yi , Leung Nelson , Herrmann Sandra M 
Published: January 2025

Abstract

Background and Hypothesis
Teclistamab, a novel bispecific monoclonal antibody targeting CD3 and B-cell maturation antigen (BCMA), and chimeric antigen receptor T-cell (CAR-T) therapy are promising options for treating relapsed/refractory multiple myeloma (MM). However, the rates of acute kidney injury (AKI) associated with teclistamab remain inadequately characterized. This study aims to compare the incidence, severity, and outcomes of AKI between patients receiving teclistamab and CAR-T therapy.

Methods
This was a retrospective study involving 64 patients with relapsed/refractory MM treated with either teclistamab or CAR-T therapy. All patients had previously received at least four lines of chemotherapy before being treated with either teclistamab or CAR-T. The primary outcome was the incidence of AKI, and secondary outcomes included AKI severity, kidney recovery rates, and mortality. Kaplan-Meier estimates for AKI-free survival were calculated, and hazard ratios (HRs) for AKI risk were determined using Cox proportional hazards models.

Results
Sixty-four patients met inclusion criteria for this study (30 received CAR-T and 34 received teclistamab therapy). Among these patients, 14 AKI events occurred in total (22%), with 10 events (29%) in the teclistamab group and 4 events (13%) in the CAR-T group. AKI-free survival estimates at 180 days after treatment initiation were 68% (95% confidence interval [CI]: 53%-87%) for teclistamab patients and 90% (95% CI: 79%-100%) for CAR-T patients. While patients receiving teclistamab were found to have an increased risk of an AKI event compared to those receiving CAR-T therapy, the results were not statistically significant (HR [95% CI]: 3.38 [0.93–12.31], P = 0.065).

Conclusions
This study suggests that patients treated with teclistamab may experience a higher incidence of AKI compared to those receiving CAR-T therapy. However, further research is required to determine whether this increased risk is attributable to disease progression or teclistamab itself. These results highlight the need for close kidney function monitoring in patients receiving teclistamab.
Prevalence of Nicotine Pouch Use Among Youth and Adults in Great Britain—Analysis of Cross-Sectional, Nationally Representative Surveys
Authors: Brose Leonie , Bunce Laura , Cheeseman Hazel 
Published: January 2025

Abstract

Background
The public health impact of new nicotine products will depend on their use by different population groups. We assessed the prevalence of nicotine pouch use among youth and adults in Great Britain (GB).

Aims and Methods
Cross-sectional annual Action on Smoking and Health Smokefree GB Adult Surveys 2020-2024 (n: 12 247 to 13 266, 18+) and Action on Smoking and Health Smokefree GB Youth Survey 2024 (n = 2872 11-18-year-olds). Weighted proportions and 95% confidence intervals for pouch ever and current use among adults over time, and in 2024 among youth and adults overall, by socio-demographics, mental health, tobacco smoking, vaping, past-12-month gambling, cannabis, and alcohol use; for youth also family members’ smoking and vaping. Multivariable logistic regression assessed the association with ever pouch use.

Results
The prevalence of adult ever and current use doubled from 2020 to 2024, reaching 5.4% (95% confidence interval = 5.0 to 5.8) and 1.0% (0.8-1.1). Among youth, 3.3% (2.7-4.0) reported ever use, including 1.2% (0.8-1.6) reporting current use. Ever use was associated with the use of other addictive products. Among adults, ever use was also more common among younger groups (18-24, 25-34, 35-44 vs. 55+), males, and those in rented accommodation or receiving mental health treatment. Among youth, ever use was also more common among those in London than elsewhere in England.

Conclusions
Pouch use in GB is rare with about 1 in 100 youth and adults reporting current use. However, use appears to be increasing and is higher in some groups, including younger adults, males and people with experience of vaping, smoking, and use of other addictive products.

Implications
While currently low, close monitoring of pouch use is indicated. It is currently concentrated among those with experience of nicotine use. However, given the higher levels of use among young adults and teenagers, consideration of regulation may be required to minimize uptake among groups that would otherwise not have used nicotine-containing products.
Bariatric Surgery Is Associated With Reduced Incidence of Mild Cognitive Impairment and Alzheimer Disease and Related Dementias: A Retrospective Cohort Study
Authors: Chen You , Feng Yubo , Zhang Xinmeng , Gifford Katherine A. , Elmanzalawi Yasser , Samuels Jason , Albaugh Vance L. , English Wayne J. , Flynn Charles R. , Yu Danxia , Zhang Rui , Ikramuddin Sayeed 
Published: January 2025

Objective:
To evaluate the association of bariatric surgery with reduced incidence and delayed development of mild cognitive impairment (MCI) and Alzheimer disease and related dementias (ADRD) in patients with obesity.

Background:
This retrospective longitudinal study utilized Electronic Health Records from Vanderbilt University Medical Center, covering 5303 patients who underwent bariatric surgery and 10,606 propensity score-matched obese patients who did not, from 2000 to 2023. Patients with prior MCI, ADRD, schizophrenia, alcoholism, gastric cancer, gastric ulcers, inflammatory bowel disease, coagulopathy, stroke, Parkinson disease, or brain cancer were excluded from both groups.

Methods:
Differences in time to MCI/ADRD between surgical and control groups were analyzed using linear regression, and adjusted for confounders: demographics, medical history, and socioeconomic status. Survival probability differences for MCI and ADRD between the 2 groups over time were assessed using Kaplan-Meier curves and log-rank tests. Incidence differences of MCI and ADRD between the groups were evaluated using Fine-Gray subdistribution hazard models, accounting for the competing risk of death and confounders.

Results:
Bariatric surgery was associated with a significantly reduced incidence of ADRD, evidenced by a subdistribution hazard ratio (SHR) of 0.37 (95% confidence interval [CI]: 0.15–0.89; P = 0.03). Similarly, the incidence of MCI was significantly lower in the surgical group, with an SHR of 0.57 (95% CI: 0.39–0.85; P = 0.01). Additionally, patients who underwent bariatric surgery experienced a delay of 2.01 years before developing MCI compared with the control group (95% CI: 0.70–3.50; P = 0.004).

Conclusions:
These findings suggest that bariatric surgery may serve as an effective strategy to delay the onset of MCI and reduce the risk of both MCI and ADRD in patients with obesity.