bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nitrogen-Fixing Plants Enhance and Stabilize Rhizospheric Soil Organic Carbon in Tropical Rainforests, Hainan Island, China
Authors: Yang Huai , Liu Shirong , Wang Jingxin , Schuler Jamie , Wang Yi , Luan Junwei 
Published: August 2023

Abstract
Nitrogen (N)-fixing plants play an important role in stimulating soil nitrogen supply, but the effect of N-fixing plants on soil organic carbon (SOC) sequestration has not been well documented. In this study, we measured rhizospheric carbon components and N content of first to second (1–2)-order and third to fifth (3–5)-order roots of N-fixing and non-N-fixing plants in a montane tropical rainforest in Hainan Island, China, to examine the effects of N-fixing plants on SOC and soil heavy fraction carbon (HFC), and to ascertain the main regulating factors. The results showed that rhizospheric SOC between (1–2) and (3–5)-order roots was 14.2% and 10.5% greater, respectively, for N-fixing plants compared with non-N-fixing plants. Similarly, the HFC was 0.9% (1–2) and 3.6% (3–5) greater for N-fixing plants than non-N-fixing plants. Redundancy analysis showed that spatial variance in rhizospheric SOC and HFC associated with 1–2-order roots was explained by specific root length (SRL) of second-order roots (55.8%) and specific leaf area (SLA) (14.6%), whereas spatial variance was better explained for 3–5 roots by total soil N (44.6%), diameter of fifth-order roots (16.4%), and leaf C (17.9%), respectively. Within the rhizospheric soil of 1–2 roots, N-fixing plants with smaller SRL of second-order roots presented greater SOC and HFC, whereas smaller SLA was associated with greater HFC. By contrast, rhizospheric soil of 3–5 roots under N-fixing plants had greater SOC and HFC levels in environments with higher total soil N and smaller diameters of fifth-order roots. Our study revealed that N-fixing plants enhanced rhizospheric SOC and HFC compared with non-N-fixing plants. The rhizospheric SOC and HFC were correlated strongly by root morphology traits, leaf morphology, and soil properties.
Study Implications: In this article, we compared rhizospheric soil of N-fixing and non-N-fixing species in a montane tropical rainforest in Hainan Island, China, to examine the effects of N-fixing plants on SOC and HFC. Our results suggest the N-fixing plants enhance and stabilize rhizospheric SOC and HFC; rhizospheric SOC and HFC for first- to second-order roots of N-fixing plants were mostly negatively regulated by SRL of second-order roots; and N-fixing plants had positive effects on rhizospheric SOC and HFC for third- to fifth-order roots through increased soil N. Understanding these mechanisms could improve and accumulation of soil C sink in tropical areas.
Post-seismic deformation of the 2008 Wenchuan earthquake reveals a misaligned rheological boundary in the lower crust along the eastern Tibetan Plateau margin
Authors: Zhao Dezheng , Qu Chunyan , Shan Xinjian , Bürgmann Roland , Chen Han , Wu Donglin , Gong Wenyu 
Published: August 2023

SUMMARYAlong the margins of orogenic plateaus, the viscous Earth structure and fault geometries play a primary role in controlling the tectonic evolution and earthquake generation. After the 2008 Mw 7.9 Wenchuan earthquake, the long-standing debate regarding the tectonics producing and maintaining prominent topography across the Longmen Shan reignited. Post-seismic deformation, representing the surface strain history in response to lithospheric stress perturbations, provides important insights into the lithospheric rheology and active structures. Here, we construct a new 3-D post-seismic deformation model for the Wenchuan earthquake, invoking viscoelastic relaxation and afterslip. Our best-fitting model indicates that the steady-state viscosities of the lower crust in the region to the immediately west of the Songpan-Ganzi terrane and beneath the Songpan-Ganzi terrane are estimated to be 4.0 × 1018 and 1.0 × 1018 Pa s, respectively. Our results, combining geophysical and geodetic observations and model analyses, highlight the prevalent parallelism between the rheological and structural boundaries of the lower crust, which diverge northward away from the trend of the Longmen Shan fault at ∼20°. This diverging rheological structure and the partially coupled upper and lower crust have broad implications for the stress build-up, strain partitioning and deformation styles along the eastern Tibetan Plateau margin.
A novel GRACE reconstructive filter to extract the mass changes in Madagascar
Authors: Jian Guangyu , Xu Chuang , Zou Fang , Huang Bo 
Published: August 2023

SUMMARYThe precise estimation of the mass changes in Madagascar is a challenge by using the Gravity Recovery and Climate Experiment (GRACE) mission Level-2 products since they are contaminated by noise. Although this issue can be alleviated by the empirical destriping method or spatial filtering, they result in potential signal distortion or signal leakage. To improve this, we propose a reconstructive filter, whose parameters are optimized by the signal-to-noise ratio. Subsequently, our optimal filter corresponding to the best signal-to-noise ratio (5.63) is used to estimate the mass changes (2002–2017) in Madagascar. Eventually, our results are compared with two reliable GRACE mascon products and other independent observations. Correspondingly, here are our major conclusions: (1) Compared with groundwater storage from the mascon products, our estimates have the highest Pearson correlation (0.5) with in situ observation and can detect the rapid increase of groundwater storage during the rainy season. (2) The Fourier spectrum analysis detects a ∼3.8-yr periodic signal in the terrestrial water storage changes in Madagascar, which is contributed from the interannual precipitation driven by climate factor (Indian Ocean Dipole) and the aliasing error for imperfect GRACE pre-process. Our work introduces an effective filter for processing GRACE Level-2 data and presents novel insights into mass changes in Madagascar.
Harnessing patient complaints to systematically monitoring healthcare concerns through disproportionality analysis
Authors: Bie Bogh Søren , Fryd Birkeland Søren , Maj-Britt Hansen Sebrina , Alexandrovna Tchijevitch Olga , Hallas Jesper , Morsø Lars 
Published: August 2023

AbstractStaff observations are the most common source of data for driving improvements in care. However, the patient perspective should also be considered, and healthcare complaints offer concrete details that health organizations might otherwise overlook and that can highlight areas for learning and improvement in the healthcare system. However, because of the diverse nature of patient complaints, systematic analyses can be challenging. This study aimed to identify and prioritize areas for improvement using a data-driven approach to analysing patient complaints. The Danish version of the Healthcare Complaints Analysis Tool was used to categorize the content of complaint letters. All complaints managed by the national complaints authority, compensation claims to the Patient Compensation Association, and locally managed complaints that were filed directly at Odense University Hospital from 2017 to 2021 were included. Proportional reporting ratios (PRRs) were used to measure and display the top five signals of disproportionality and rank them by excess complaints at the hospital level and when divided into department types. The study included 6366 complaints containing 13 156 problems (on average, 2.1 problems mentioned per complaint letter). Surgical departments had the highest number of complaints (3818), followed by medical (1059), service (439), and emergency departments (239). Signal 1 of disproportionality, relating to quality problems during ward procedures, had the highest excess reporting of 1043 complaints at the hospital level and a PRR of 1.61 and was present in all department types. Signal 2, relating to safety problems during the examination and diagnosis stage, had an excess reporting of 699 problems and a PRR of 1.86 and was also present in all department types. Signal 3, relating to institutional problems during admission, had the highest PRR of 3.54 and was found in most department types. Signals 4 and 5, relating to environmental problems during ward procedures and care on the ward, respectively, had PRRs of 1.5 and 1.84 and were present in most department types. The study found that analysing patient complaints can identify potential areas for hospital improvement. The study identified recurring issues in multiple departments, including quality problems during ward procedures, safety problems during the examination, institutional problems during admission, and environmental problems on the ward. The study highlights disproportionality analysis of complaints as a valuable tool to monitor patient concerns systematically.
Activity of ceftolozane/tazobactam and imipenem/relebactam against clinical isolates of Enterobacterales and Pseudomonas aeruginosa collected in central and northern Europe (Belgium, Norway, Sweden, Switzerland)—SMART 2017–21
Authors: Karlowsky James A , Lob Sibylle H , Hawser Stephen P , Kothari Nimmi , Siddiqui Fakhar , Alekseeva Irina , DeRyke C Andrew , Young Katherine , Motyl Mary R , Sahm Daniel F 
Published: August 2023

Abstract

Objectives
To evaluate the in vitro activities of ceftolozane/tazobactam and imipenem/relebactam against clinical isolates of Gram-negative bacilli collected in four central and northern European countries (Belgium, Norway, Sweden, Switzerland) during 2017–21.

Methods
Participating clinical laboratories each collected up to 250 consecutive Gram-negative isolates per year from patients with bloodstream, intraabdominal, lower respiratory tract or urinary tract infections. MICs were determined by CLSI broth microdilution and interpreted using 2022 EUCAST breakpoints. β-Lactamase genes were identified in select β-lactam-non-susceptible isolate subsets.

Results
Ninety-five percent of all Enterobacterales (n = 4158), 95% of ESBL-positive non-carbapenem-resistant Enterobacterales (non-CRE) phenotype Escherichia coli and 85% of ESBL-positive non-CRE phenotype Klebsiella pneumoniae were ceftolozane/tazobactam susceptible. By country, 88% (Belgium), 91% (Sweden, Switzerland) and 96% (Norway) of ESBL-positive non-CRE phenotype Enterobacterales were ceftolozane/tazobactam susceptible. Greater than ninety-nine percent of non-Morganellaceae Enterobacterales and all ESBL-positive non-CRE phenotype Enterobacterales were imipenem/relebactam susceptible. Ceftolozane/tazobactam (96%) and imipenem/relebactam (95%) inhibited most Pseudomonas aeruginosa (n = 823). Both agents retained activity against ≥75% of cefepime-resistant, ceftazidime-resistant and piperacillin/tazobactam-resistant isolates; 56% and 43% of meropenem-resistant isolates were ceftolozane/tazobactam susceptible and imipenem/relebactam susceptible, respectively. By country, 94% (Belgium), 95% (Sweden) and 100% (Norway, Switzerland) of P. aeruginosa were ceftolozane/tazobactam susceptible and 93% (Sweden) to 98% (Norway, Switzerland) were imipenem/relebactam susceptible. Carbapenemase gene carriage among Enterobacterales and P. aeruginosa isolates was generally low (&lt;1%) or completely absent with one exception: an estimated 2.7% of P. aeruginosa isolates from Belgium carried an MBL.

Conclusions
Recent clinical isolates of Enterobacterales and P. aeruginosa collected in four central and northern European countries were highly susceptible (≥95%) to ceftolozane/tazobactam and imipenem/relebactam.
The impact of protein source and grain inclusion on digestibility, fecal metabolites, and fecal microbiome in adult canines
Authors: Clark Stephanie D , Hsu Clare , McCauley Sydney R , de Godoy Maria R C , He Fei , Streeter Renee M , Taylor Emily G , Quest Bradley W 
Published: August 2023

AbstractThis study was conducted to determine the effect of animal protein inclusion rate and grain-free or grain-inclusive diets on macronutrient digestibility, fecal characteristics, metabolites, and microbiota in mixed-breed hounds and Beagles. Four experimental extruded kibble diets were made with varying amounts of animal protein and carbohydrates: 1) high animal protein, grain-inclusive (HA-GI), 2) low animal protein, grain-free (LA-GF), 3) low animal protein, grain-inclusive (LA-GI), and 4) high animal protein, grain-free (HA-GF). Thirty-two Beagles and 33 mixed-breed hounds were assigned to 1 of the 4 treatment groups in a completely randomized design that lasted 180 d. All diets were similar in chemical composition and well-digested by the animals. In general, for fecal metabolites, mixed-breed hounds had a greater concentration of total short-chain fatty acid (SCFA) and ammonia and lower indole concentration than Beagles (P &lt; 0.05). In mixed-breed hounds, LA-GF had a greater (P &lt; 0.05) total SCFA concentration than HA-GI and LA-GI; however, this was not observed in Beagles. There were greater concentrations of ammonia, phenol, and indole in HA-GI than in LA-GF (P &lt; 0.05). Breed-affected fecal primary bile acid (BA) concentration, as mixed-breed hounds had a greater concentration of cholic acid (CA) than Beagles (P &lt; 0.05). Mixed-breed hounds fed LA-GF resulted in greater CA concentrations than HA-GI and LA-GI (P &lt; 0.05). Dogs who consumed LA-GF had lower fecal secondary BA content than the other groups (P &lt; 0.05). The distribution of the fecal microbiota community differed in LA-GF compared with the other groups, with lower α-diversity. However, dogs fed LA-GF had the largest difference in composition with greater Selenomonadaceae, Veillonellaceae, Lactobacillaceae, Streptococcus, Ligilactobacillus, Megamonas, Collinsella aerofaciens, and Bifidobacterium sp. than the other groups. A significant breed effect was noted on nutrient digestibility, fecal metabolites, and microbiota. A treatment effect was observed in LA-GF as it resulted in greater fecal SCFA, lower protein fermentative end products, greater fecal primary BAs, lower fecal secondary BA concentrations, and shifts in fecal microbiota.
A second iron injection administered to piglets during lactation improves hemoglobin concentration, growth performance, and carcass characteristics at slaughter
Authors: Chevalier Tyler B , Lyons Wesley , Paczosa Duncan B , Rentfrow Gregg K , Lindemann Merlin D 
Published: August 2023

AbstractAn experiment was conducted to evaluate the effects of a second injection of iron dextran administered on days 6 to 8 of age. A total of 144 crossbred pigs (equal barrows and gilts; initial age 6 to 8 d; initial body weight [BW] = 2.86 ± 0.01 kg) were assigned to either the control (CON) or an added-injection treatment (+Fe). Pigs were paired by sex and BW within a litter and randomly assigned to the iron treatment within each pair. All pigs had received an initial intramuscular (IM) injection of iron dextran (200 mg Fe) &lt;24 h after birth. Pigs assigned to the +Fe treatment received a second IM injection of iron dextran (200 mg Fe) on days 6 to 8. All pigs were weaned at 22 to 25 d, housed 6 pigs/pen, and received a common corn–soybean meal diet. BW and feed disappearance were recorded every 2 wk. Hemoglobin (Hb) concentrations were measured at birth, initiation of experiment (days 6 to 8), weaning, and the end of the nursery and end of the study. At the end of the study, 1 pig/pen (n = 12 pigs/treatment), closest to the pen mean was selected and slaughtered for carcass characteristic measures. The individual pig served as the experimental unit for BW, Hb, average daily gain (ADG), and carcass characteristic data whereas the pen served as the experimental unit for average daily feed intake, and gain/feed ratio data. The +Fe pigs had a greater Hb at weaning (13.1 vs. 10.7 g/dL, respectively; P &lt; 0.01) and end of the nursery (12.1 vs. 11.7 g/dL, respectively; P = 0.01) compared to CON pigs. During the finisher period, +Fe pigs had a greater ADG (0.94 vs. 0.91 kg, respectively; P = 0.05) compared to CON pigs. Overall, pigs receiving the second iron injection had an ~4% increase in ADG (P = 0.04) from weaning to the end of study. The cumulative improvement in ADG from weaning to the end of study observed for +Fe group resulted in +Fe pigs having a heavier BW at the end of the study (~3 kg; P = 0.04). Following slaughter, +Fe pigs had ~7.2% heavier trimmed loin (P = 0.04) compared to the CON pigs. In conclusion, administering a second iron injection resulted in greater Hb at weaning and the end of the nursery as well as improved growth performance from weaning to the end of study weight and increased carcass weight at slaughter.
An unusual route of odontogenic infection from the mandible to the orbit through the facial spaces, resulting in blindness: a rare case report
Authors: Nashawi Faez Ebrahim , Alkheder Ahmad , Shasho Hamza Omar , Abdullah Lava , Mohsen Adham bader aldeen 
Published: August 2023

Abstract
Orbital infection is a rare complication of odontogenic infections, mostly originating from maxillary teeth. In our case, we present one of the unusual routes by which an odontogenic infection of a lower molar tooth has spread into the orbit. A 67-year-old uncontrolled diabetic patient was referred to our hospital with a complaint of a swollen right masseteric region and orbital infection following a dental procedure on the right mandibular third molar. Computed tomography scan and magnetic resonance imaging showed multiple abscesses localized in the masseteric and infratemporal spaces, extending into the orbital cavity through bony erosion in the lateral orbital with no sinus involvement. Improper treatment and poorly controlled diabetes resulted in the extensive spread of the infection. Clinical and radiological reevaluation has played a major role in the management of our case by elucidating the route of infection and localizing abscess foci accurately.
Left brachiocephalic venous thrombus initially presenting as acute aortic syndrome
Authors: Yang Amy , Seevanayagam Siven 
Published: August 2023

Abstract
Upper extremity deep venous thrombosis (UEDVT) is rare but carries significant morbidity. Primary UEDVT presents non-specifically and there are no clear diagnostic or management guidelines, which are essential for early treatment to prevent potentially devastating complications such as pulmonary embolus or post-thrombotic pain syndrome. A patient with left brachiocephalic vein UEDVT initially diagnosed radiographically as an acute aortic syndrome and referred to a cardiothoracic unit is presented. Computed tomography venogram confirmed the diagnosis of UEDVT and therapeutic anticoagulation was started. This case highlights the need for validated diagnostic and management algorithms for UEDVT. Furthermore, this relatively rare condition should be considered for patients with acute chest pain and abnormal imaging referred to surgical units.
Gastric conduit reconstruction after esophagectomy with right gastroepiploic artery absence: a case report
Authors: Charalampous C , Kofopoulos-Lymperis E , Pikouli A , Lykoudis P , Pararas N , Papaconstantinou D , Nastos C , Myoteri D , Dellaportas D 
Published: August 2023

Abstract
Gastric conduit reconstruction is the standard choice after esophagectomy. Conduit’s vascular supply is of primary importance mainly based on right gastroepiploic vessels. A 57-year-old male with absent right gastroepiploic artery, due to a duodenal bleeding ulcer treated with gastroduodenal artery ligation 10 years ago, was treated for gastroesophageal cancer and required esophagectomy. Surgical merits of this troublesome scenario are highlighted. Previous surgical history is highly important for patients requiring complex surgery as esophagectomy. The use of the stomach as conduit after esophagectomy is always the primary option; however vascular supply of it should not be compromised. Variations are rare and careful planning may overcome obstacles as in this case.
Some completeness results in derivational modal logic
Authors: Gougeon Quentin 
Published: August 2023

Abstract
Alongside the traditional Kripke semantics, modal logic also enjoys a topological interpretation, which is becoming increasingly influential. In this paper, we present various developments related to the topological derivational semantics, based on the Cantor derivative operator. We provide several characterizations of the validity of the axioms of bounded depth. We also elucidate the topological interpretation of the axioms of directedness and connectedness—which come in different forms, all of which we examine. We then prove results of soundness and completeness for all of these logics, using a range of old and new techniques.
Characteristic functions for cosmological cross-correlations
Authors: Breysse Patrick C , Chung Dongwoo T , Ihle Håvard T 
Published: August 2023

ABSTRACT
We introduce a novel unbiased, cross-correlation estimator for the one-point statistics of cosmological random fields. One-point statistics are a useful tool for analysis of highly non-Gaussian density fields, while cross-correlations provide a powerful method for combining information from pairs of fields and separating them from noise and systematics. We derive a new Deconvolved Distribution Estimator that combines the useful properties of these two methods into one statistic. Using two example models of a toy Gaussian random field and a line intensity mapping survey, we demonstrate these properties quantitatively and show that the deconvolved distribution estimator can be used for inference. This new estimator can be applied to any pair of overlapping, non-Gaussian cosmological observations, including large-scale structure, the Sunyaev–Zeldovich effect, weak lensing, and many others.
Incidence and Resolution of Eribulin-Induced Peripheral Neuropathy (IRENE) in Locally Advanced or Metastatic Breast Cancer: Prospective Cohort Study
Authors: Lück Hans-Joachim , Schmidt Marcus , Hesse Tobias , Hoffmann Oliver , Heinrich Bernhard J , Park-Simon Tjoung-Won , Grischke Eva-Maria , Weide Rudolf , Müller-Huesmann Harald , Lüdtke-Heckenkamp Kerstin , Fischer Dorothea , Zemlin Cosima , Kögel Matthias , Wu Jane , Schmitz Helga , Engelbrecht Christian , Jackisch Christian 
Published: August 2023

Abstract

Background
Eribulin, a halichondrin-class microtubule dynamics inhibitor, is a preferred treatment option for patients with advanced breast cancer who have been pretreated with an anthracycline and a taxane. Peripheral neuropathy (PN) is a common side effect of chemotherapies for breast cancer and other tumors. The Incidence and Resolution of Eribulin-Induced Peripheral Neuropathy (IRENE) noninterventional postauthorization safety study assessed the incidence and severity of PN in patients with breast cancer treated with eribulin.

Patients and Methods
IRENE is an ongoing observational, single-arm, prospective, multicenter, cohort study. Adult patients (≥18 years of age) with locally advanced or metastatic breast cancer and disease progression after 1-2 prior chemotherapeutic regimen(s) for advanced disease were treated with eribulin. Patients with eribulin-induced PN (new-onset PN or worsening of preexisting PN) were monitored until death or resolution of PN. Primary endpoints included the incidence, severity, and time to resolution of eribulin-induced PN. Secondary endpoints included time to disease progression and safety.

Results
In this interim analysis (data cutoff date: July 1, 2019), 67 (32.4%) patients experienced any grade eribulin-induced PN, and 12 (5.8%) patients experienced grade ≥3 eribulin-induced PN. Median time to resolution of eribulin-induced PN was not reached. Median time to disease progression was 4.6 months (95% CI, 4.0-6.5). Treatment-emergent adverse events (TEAEs) occurred in 195 (93.8%) patients and serious TEAEs occurred in 107 (51.4%) patients.

Conclusion
The rates of any grade and grade ≥3 eribulin-induced PN observed in this real-world study were consistent with those observed in phase III randomized clinical trials. No new safety findings were observed.