bluuebunny/crossref_metadata_2025_split huggingface dataset:
The influence of lifestyle on the state of health of students
Authors: Biletska Viktoriia , Semenenko Viacheslav , Zavalnyuk Viktoriia , Yaremenko Oleg , Litvinova Kseniia 
Published: May 2023

The article examines the influence of lifestyle on the state of health of students of higher education of different years of study. The factors that encourage students of the first and fourth years of study to organize a healthy lifestyle have been determined. Aspects of a healthy lifestyle, which students strive to follow, are considered, because they consider them the most important for maintaining and strengthening health. The reasons for the use of drugs, alcoholic beverages and smoking have been established. Also, the peculiarities of students' observance of a rational daily regime and the use of a hardening system are determined.
The results of the student survey show that among the factors that could encourage students to organize a healthy lifestyle, the desire to maintain a physical shape and looks good as long as possible is in the first place among students of the 1st and 4th year. Self- realization in the profession is secondary for 1st-year students, and for 4th-year students - care for their health. In third place for 1st-year students is the acquisition of knowledge, skills and abilities to preserve and strengthen health, and for 4th-year students - the importance of health for the well-being and peace of their relatives and friends.
According to the results of the survey of students of the 1st and 4th courses, it was found that 100% of the 1st-year students and 92% of the 4th-year students strive to follow a rational daily routine. 70% of 1st-year students and 50% of 4th-year students consider it appropriate to use the hardening system. 88% of surveyed 1st-year students believe that parents and friends can encourage a person to lead a healthy lifestyle. Among the students of the 4th year, only 70% of them think so.
THE PRINCIPLE THAT THE LAND DOMINATES THE SEA IN THE CONTEXT OF SOUTH CHINA SEA DISPUTES: A CRITICAL APPRAISAL
Authors: Hamid Abdul Ghafur 
Published: May 2023

According to the principle that the land dominates the sea, the land is always the basis for any claim of maritime entitlements. Without a land with a coastline or coastal front under its sovereignty, no state can claim any maritime entitlement. The land here includes not only the continental mainland but also islands which may generate the same maritime entitlements. Nonetheless, certain claimants of the South China Sea have rejected or tried to bend the principle in furtherance of their respective claims. The main objective of the present paper, therefore, is to assess the status of the principle as customary international law and its application to the nine-dash-line claim of China and other claims based on maritime features such as atolls, coral reefs, shoals, and the like. The paper reviews the decisions of the international courts and tribunals on one hand and analyses the relevant provisions of the UNCLOS on the other. The paper also applies interpretative tools to reaffirm the meaning of Article 121 of the UNCLOS: the regime of islands. The paper concludes that the claim of historic rights in the nine-dash-line is not squarely in accord with the principle and that most of the claims on the South China Sea that are based on artificially built structures and land reclamation defeat the letter and spirit of the regime of islands, which is a manifestation of the principle that the land dominates the sea.
ANALISIS PERANCANGAN ULANG TATA LETAK MATERIAL PADA GUDANG DENGAN MENGGUNAKAN METODE SHARED STORAG
Authors: Sidabutar Sadat NS , Kartika Siska Ayu , Ramadhan Erik 
Published: May 2023

Abstrak Tata Letak Fasilitas adalah suatu pengaturan atau tata cara dan penempatan yang optimal fasilitas-fasilitas pabrik/gudang. Kondisi penataan yang tidak berdasarkan suatu perancangan tata letak dapat menyebabkan tidak efisiennya waktu penanganan material karena keterbatasan gudang tersebut. Permasalahan yang dihadapi PT. XYZ adalah kurang baiknya penataan barang/produk yang kurang tepat pada gudang menimbulkan masalah pada gudang yang dikelola, sehingga gudang terkesan kurang tertata. Penempatan produk yang kurang tepat, dan memiliki frekuensi proses masuk dan keluarnya terbanyak di tempatkan paling belakang. Hal ini menyebabkan material handling kurang efektif sehingga memerlukan waktu lebih lama. Waktu penelitian dilaksanakan pada bulan Oktober sampai bulan Desember 2022. Penelitian dilaksanakan di PT. XYZ Balikpapan, Objek penelitian ini adalah bagian sistem manajeman gudang. Penelitian menggunakan metode shared storage, dengan variabel bebas: raw material, quantity raw material, variabel terikat: efektivitas, kebutuhan ruang dan luas area penyimpanan, variabel kontrol: luas Gudang. Hasil dari pendekatan shared storage dapat meminimalisasi total jarak tempuh material handling menjadi 4.537 meter sedangkan kondisi sebelumnya total jarak tata letak awal adalah 7.317 meter terjadi selisih jarak 2.780 meter dari total jarak, dan terjadi penurunan total jarak 37%Kata kunci : Tata letak, Metode Shared Storage, Material handling
10-Year Cardiovascular Risk, Serum Lipid Indices and High Sensitivity CRP in a Healthy Population
Authors: AKINCI Sinan , AKBAY Ertan 
Published: May 2023

Objective: It is very important to identify individuals at high risk of atherosclerotic cardiovascular diseases (ASCVD) and for this purpose, many risk calculation tools and parameters are used. In this study, we aimed to investigate the correlation between the ACC/AHA cardiovascular risk and serum lipid indices and high sensitivity C-reactive protein (hs-CRP) in a healthy population.
Methods: Our study was conducted retrospectively on individuals aged between 40 and 79 years and with sufficient data, using the hospital database. Patients with a history of any chronic disease and active infection were excluded. Individuals were analyzed by grouping them into low (5%) estimated 10-year risk of ASCVD.
Results: 184 individuals with a median age of 46 and 37.5% women were included in the study. The median 10-year estimated risk of ASCVD in the study population was 3% (1.3/5.98). The low-risk group had a significantly lower atherogenic index of plasma (AIP), Castelli I risk index (CR-I), and Castelli II risk index (CR-II) compared to the borderline to high-risk group (p
The association between abnormal vaginal microbial flora and preterm labor. Does a simple Gram's stain of vaginal swab gives more useful data than culture ?
Authors: Al Shamma'a Haider 
Published: May 2023

Fac Med Baghdad
2014; Vol.56, No.2
Received: Jan., 2014
Accepted March. 2014

Background: Preterm labor is the major cause of perinatal mortality and morbidity and it is a challenging obstetrical complication as treatment is marginally effective if ever and no improvement in incidence over the last 5 decades , although may causes were identified the majority are idiopathic and in this category infection seems to be involved as a causative agent
Objectives: to evaluate the association of abnormal vaginal flora diagnosed by direct Gram's staining and vaginal culture with preterm labor.
Patients, material and methods: 25 women with preterm labor compared with 25 women at full term pregnancy, high vaginal swabs for direct Gram's staining (Spiegel criteria for abnormal vaginal flora) and culture. The results were compared in both group
Results: this study showed significant association between preterm labor and abnormal vaginal flora 7 (28%) and 12 (48%) of grade II and III respectively . and a significant association between term pregnancy and normal vaginal flora 16 (64%) of grade I. Also in the presence of abnormal vaginal flora, no significant association with type of pathogenic microorganism and preterm labor as all types may be associated with PTL , and the presence of Lactobacillus spp. (normal grade I flora ) is associated with term pregnancy.
Conclusions: Gram's staining of high vaginal swab using Spiegel criteria can be useful simple test to predict preterm labor
Dynamics of blood cells during a routine laboratory examination
Authors: Taye Mesfin 
Published: May 2023

Centrifugation is a commonly performed laboratory procedure that helps to separate blood cells such as red blood cells \(RBCs\), white bood cells \(WBCs\), and platelets from plasma or serum. Although centrifugation is a routine procedure in most medical laboratories, factors that affect the efficacy of the centrifugation process have never been studied analytically. In this paper, we examine the effect of centrifugation time on the efficacy of the centrifugation process by studying the dynamics of blood cells via the well-known Langevin equation or equivalently, by solving the Fokker-Plank equation. Our result depicts that the speed of the centrifuge is one of the determinant factors concerning the efficacy of the centrifugation process. As angular speed increases, centrifugal force increases and as a result, the particles are forced to separate from plasma or serum. The room temperature also considerably affects the dynamics of the sample during centrifugation. Most importantly, the generation of heat during centrifugation increases the temperature within a centrifuge, and as a result, not only the stability of the sample but also the mobility of analyse is affected. We show that as the temperature within the centrifuge intensifies, the velocity of the cells as well as the displacement of the cells in the fluid increases. We then study the dynamics of the whole blood during capillary action where in this case the blood flows upward in a narrow space without the assistance of external forces. Previous investigations show that the height that the fluid rises increases as surface tension steps up. The viscosity of the fluid also affects the capillary action but to date, the dependence of the height on viscosity has never been explored due to the lack of a mathematical correlation between the viscosity of blood and surface tension [1]. In this work, we first examine the correlation between surface tension and viscous friction via data fitting. Our result exhibits that the viscosity of the blood increases linearly as surface tension increases. The mathematical relation between the height and viscous friction is derived. It is shown that the height of the blood that rises in the capillary increases as the viscous friction intensifies. As the temperature of the room steps up, the height also decreases. The dependence of erythrocytes sedimentation rate on surface tension is also studied. The results obtained in this work show that the erythrocyte sedimentation rate ESR increases as surface tension steps down.
Desarrollo de la motricidad fina con actividades lúdicas en educación inicial
Authors: López Ocaña Verónica Patricia , Pomboza Muyulema Sandra Paulina , Pomboza Muyulema Yolanda del Pilar , Pomboza Muyulema Elsa Verònica 
Published: May 2023

Introducción: debido a la situación que se vivió por el COVID 19, y al hecho de que los estudiantes de educación inicial luchan con sus habilidades motoras finas, lo que también podría sugerir otros problemas con su coordinación visomotora, agarre de pinza digital, agilidad y precisión en sus movimientos; la importancia de esta investigación parte de que las habilidades motoras finas son un componente clave del desarrollo cognitivo general. Objetivo: determinar la importancia de las actividades lúdicas y el desarrollo de la motricidad fina en estudiantes de educación inicial de 4 años en la Unidad Educativa de Santa Rosa. Metodología: enfoque cuantitativo, cuasi-experimental y un diseño descriptivo, correlativo y con un tamaño muestral de 24 estudiantes en el grupo control y 25 estudiantes en el grupo experimental, para determinar si se realizan pruebas paramétricas o no, se aplicaron pruebas de normalidad. Resultados: se realizó una prueba no paramétrica para verificar la hipótesis. Los hallazgos más llamativos que se destacaron en el estudio fueron los siguientes: para el grupo experimental en el pretest, una media de 2.28 en una escala de 5 significó "iniciado", y para el grupo experimental en el post test, una media de 4,84 significaba "adquirido". Conclusión: la técnica utilizada durante la intervención de tres semanas produjo resultados positivos.
Análise da estrutura fundiária na bacia hidrográfica do rio Uruçuí-Preto, Piauí
Authors: Figueredo Elayne da Silva , Silva Antônio Joaquim da , Moura Joana Tereza Vaz de 
Published: May 2023

O processo de expansão da fronteira agrícola nos cerrados brasileiros tem sido potencializado pelo atrativo preço das terras, por infraestruturas e por incentivos estatais criados para difusão dos negócios agropecuários, além das condições naturais favoráveis. Nesse sentido, a recente dinâmica produtiva e extrativista do solo e dos recursos naturais coloca em risco a água, um elemento fundamental para a vida humana. Nesse trabalho, foi analisado a infraestrutura fundiária dos municípios que compreende a Bacia Hidrográfica do Rio Uruçuí-Preto, utilizando as bases cadastrais públicas do Sistema de Gestão Fundiária (SIGEF) e do Sistema Nacional de Certificação de Imóveis Rurais (SNCI). Estes municípios possuem elevada produção de commodities agrícolas visando a exportação, sobretudo soja. Como resultados, destaca-se que o município de Uruçuí, reconhecido na literatura como pioneiro em atrair empresas de agronegócios, possui 30,79% do total da quantidade de imóveis definidos como pequena e medias propriedades, enquanto municípios como Santa Filomena e Baixa Grande do Ribeiro apresentam 85,47% e 82,92%, respectivamente. Os resultados ressaltam, ainda, o potencial agrícola produtivo desses municípios, ao tempo que evidencia a concentração fundiária de terras nessa região.
PENGARUH TERAPI BIRTH BALL TERHADAP TINGKAT KECEMASAN DAN PENURUNAN INTENSITAS NYERI PADA IBU BERSALIN PRIMIPARA KALA I FASE AKTIF
Authors: Sri Anggraeni Anggun , Yenny Aulya  , Retno Widowati  
Published: May 2023

Pada ibu bersalin akan timbul kontraksi yang menyebabkan nyeri. Nyeri pada proses persalinan dapat membuat ibu menjadi cemas. Kecemasan dapat menyebabkan psikologi ibu terganggu. Nyeri dapat menyebabkan hormon steroid dan katekolamin dilepaskan, sehingga dapat menimbulkan ketegangan otot polos dan vasokonstriksi pembuluh darah. Proses tersebut menyebabkan terjadinya penurunan kontraksi, aliran oksigen dan darah ke uterus berkurang, serta adanya iskemia pada uterus. Hal ini menimbulkan bertambahnya jumlah impuls nyeri. Bebagai cara komplementer dilakukan untuk menurunkan rasa nyeri pada ibu bersalin. Tujuan penelitian ini untuk mengetahui pengaruh terapi birth ball terhadap tingkat kecemasan dan penurunan intensitas nyeri pada ibu bersalin primipara kala I fase aktif. Penelitian ini menggunakan metode quasi eksperimen dengan rancangan one group pre test pos test design pada 20 ibu bersalin sebagai responden. Terapi birth ball dilakukan selama 20 menit. Analisis data menggunakan paired sample t-test dengan nilai alfa 0,05. Hasil penelitian menunjukan rata-rata skor kecemasan sebelum terapi birth ball adalah 80,95 dan setelah terapi birth ball adalah 55,40. Rata-rata skor intensitas nyeri sebelum terapi birth ball adalah 7,45 dan setelah terapi birth ball adalah 3,80. Hasil paired sample t-test menghasilkan nilai signifikansi (2-tailed) 0,000. Simpulan pada penelitian ini adalah terdapat perbedaan yang signifikan skor rata-rata tingkat kecemasan dan intensitas nyeri ibu sebelum dan setelah dilakukan terapi birth ball.
Kata kunci: birth ball, ibu bersalin, kecemasan, nyeri,.
Activation effects on the physical characteristics of T lymphocytes
Authors: Waugh Richard E. , Lomakina Elena , Amitrano Andrea , Kim Minsoo 
Published: May 2023

The deformability of leukocytes is relevant to a wide array of physiological and pathophysiological behaviors. The goal of this study is to provide a detailed, quantitative characterization of the mechanical properties of T cells and how those properties change with activation. We tested T cells and CD8+ cells isolated from peripheral blood samples of healthy donors either immediately (naïve population) or after 7 days of activation in vitro. Single-cell micropipette aspiration was used to test the mechanical properties. T cells exhibit the general characteristics of a highly viscous liquid drop with a cortical “surface” tension, Tcort. The time course of each cell entry into the micropipette was measured at two different aspiration pressures to test for shear thinning behavior. The data were analyzed in the framework of an approximate mechanical model of the cell deformation to determine the cortical tension, the cell volume, the magnitude of the initial cell entry, the characteristic viscosity μo, and the shear thinning coefficient, b. Activation generally caused increases in cellular resistance to deformation and a broadening of the distribution of cell properties. The cell volume increased substantially upon cell activation from ∼200 μm3 to ∼650 μm3. Naive and activated T cells had similar mean cortical tension (∼150 pN/μm). However, compared to naïve CD8+ cells, the cortical tension of activated CD8+ cells increased significantly to ∼250 pN/μm. Dynamic resistance of naive CD8+ T cells, as reflected in their characteristic viscosity, was ∼870 Pa and significantly increased to 1,180 Pa after in vitro activation. The magnitude of the instantaneous projection length as the cell enters the pipette (Linit) was more than doubled for activated vs. naive cells. All cell types exhibited shear thinning behavior with coefficients b in the range 0.5–0.65. Increased cell size, cortical tension, and characteristic viscosity all point to increased resistance of activated T cells to passage through the microvasculature, likely contributing to cell trapping. The increased initial elastic response of cells after activation was unexpected and could point to instability in the cell that might contribute to spontaneous cell motility.
Chondrocyte-like cells in nucleus pulposus and articular chondrocytes have similar transcriptomic profiles and are paracrine-regulated by hedgehog from notochordal cells and subchondral bone
Authors: Hagizawa Hiroki , Koyamatsu Saeko , Okada Seiji , Kaito Takashi , Tsumaki Noriyuki 
Published: May 2023

Objective: The nucleus pulposus (NP) comprises notochordal NP cells (NCs) and chondrocyte-like NP cells (CLCs). Although morphological similarities between CLCs and chondrocytes have been reported, interactions between CLCs and NCs remain unclear. In this study, we aimed to clarify regulatory mechanisms of cells in the NP and chondrocytes.Design: We performed single-cell RNA sequencing (scRNA-seq) analysis of the articular cartilage (AC) and NP of three-year-old cynomolgus monkeys in which NCs were present. We then performed immunohistochemical analysis of NP and distal femur. We added sonic hedgehog (SHH) to primary chondrocyte culture.Results: The scRNA-seq analysis revealed that CLCs and some articular chondrocytes had similar gene expression profiles, particularly related to GLI1, the nuclear mediator of the hedgehog pathway. In the NP, cell–cell interaction analysis revealed SHH expression in NCs, resulting in hedgehog signaling to CLCs. In contrast, no hedgehog ligands were expressed by chondrocytes in AC samples. Immunohistochemical analysis of the distal end of femur indicated that SHH and Indian hedgehog (IHH) were expressed around the subchondral bone that was excluded from our scRNA-seq sample. scRNA-seq data analysis and treatment of primary chondrocytes with SHH revealed that hedgehog proteins mediated an increase in hypoxia-inducible factor 1-alpha (HIF-1α) levels.Conclusion: CLCs and some articular chondrocytes have similar transcriptional profiles, regulated by paracrine hedgehog proteins secreted from NCs in the NP and from the subchondral bone in the AC to promote the HIF-1α pathway.
Chemical interactions in composites of gellan gum and bioactive glass: self-crosslinking and in vitro dissolution
Authors: Astanina A. , Koivisto J. T. , Hannula M. , Salminen T. , Kellomäki M. , Massera J. 
Published: May 2023

Graphical AbstractSchematic of the crosslinking process of gellan gum by Ca2+ and Mg2+ released from bioactive glass.
Interactions between vaginal local cytokine IL-2 and high-risk human papillomavirus infection with cervical intraepithelial neoplasia in a Chinese population-based study
Authors: Zhu Ruoxi , Wang Wenhao , Yang Aiming , Zhao Weihong , Wang Wei , Wang Zhilian , Wang Jintao , Hou Yongli , Su Xiaoqiang , Zhang Lili , Feng Bo , Yang Jing , Wang Zhe , Niu Xiaofen , Lv Weiguo , Qu Zhican , Hao Min 
Published: May 2023

BackgroundAlthough interleukin-2 (IL-2) has long been associated with cancer development, its roles in the development of cervical cancer remains unclear. Few studies examined the associations between IL-2 and high-risk human papillomavirus (HPV) with risk of cervical intraepithelial neoplasia (CIN).ObjectiveWe aimed to assess the association of IL-2 and high-risk HPV infection with risk of CIN as well as their interactions on the risk of CIN.DesignWe performed a cross-sectional analysis of screening data in 2285 women aged 19-65 years who participated in an ongoing community-based cohort of 40,000 women in Shanxi, China in 2014-2015. Both categorical and spline analyses were used to evaluation the association between IL-2 in the local vaginal fluids and prevalence of CIN. In addition, 1503 controls were followed up until January 31, 2019), the nested case-control study design was adopted to evaluate the association of vaginal lavage IL-2 levels and the risk of CIN progression.ResultsAfter adjusting for potential confounders, IL-2 levels were statistically inversely associated with prevalence of CIN (the 1st versus 4th quartile IL-2 levels: the respective odds ratio [OR] and 95% confidence intervals [CI] was: = 1.75 [1.37, 2.23] for CIN, 1.32 [1.01, 1.73] for CIN I, and 3.53 [2.26, 5.52] for CIN II/III). Increased IL-2 levels were inversely associated with prevalence of CIN (P-overall&lt;0.01, P-nonlinearity&lt;0.01 for CIN; P-overall&lt;0.01, P-nonlinearity = 0.01 for CIN I; P-overall &lt;0.01, P-nonlinearity = 0.62 for CIN II/III). The highest prevalence of CIN was observed in women with high-risk HPV, who also had the lowest IL-2 levels (P-interaction &lt; 0.01). Nested case-control study observed an inverse association between IL-2 levels and risk of CIN progression (OR=3.43, [1.17, 10.03]).ConclusionsIL-2 levels in the local vaginal fluids were inversely associated with the risk of CIN in Chinese women either with or without high-risk HPV infection.