bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sexual well‐being needs of patients with chronic illness expressed in health care: A scoping review
Authors: Igerc Irina , Schrems Berta 
Published: June 2023

AbstractAimsTo systematically identify and summarize the needs of chronically ill people concerning their sexual well‐being in peer‐reviewed published literature, to enable healthcare professionals to provide support in self‐management satisfying the needs.DesignA scoping review was performed according to the framework of (JBI Manual for Evidence Synthesis. JBI Global Wiki, 2020). Findings are reported in line with the PRISMA extension for scoping reviews.Review MethodsA literature search and thematic analysis were conducted.Data SourcesFull research was carried out in 2022 in the search engine BASE and the following databases: Scopus, MEDLINE, Science Citation Index Expanded, Social Sciences Citation Index and CINAHL. Peer‐reviewed articles published after 2011 were included.ResultsFifty articles could be found. Seven categories of needs could be identified. People with chronic diseases want their providers to initiate discussions about sexual concerns and treat them trustfully and respectfully. Most of the patients would like the issue of sexuality to be included in routine care. They perceive their medical specialists and psychologists as preferred providers to talk to about this issue. Nurses are seen as primary contact persons but in a smaller number of studies.ConclusionAlthough the scoping review included different types of chronic diseases, the needs of chronically ill patients concerning their sexual well‐being are not very different. Healthcare professionals, especially nurses, who are often the first point of contact for people with chronic illnesses, should take the initiative for open discussions about sexual issues. That requires a new understanding of the role of nurses, training and further education.Implications for the Profession and/or Patient CareProviding patient education and facilitating an open discussion about sexuality require further training in the new understanding of the role of the nurse and the concept of sexual well‐being.ImpactWhat problem did the study address? Chronic diseases have an impact on patients' sexuality. Patients want to be informed about sexual issues, but providers often do not address them. What were the main findings? Patients with a chronic condition expect providers to initiate discussions about sexual well‐being, regardless of the type of chronic disease. Where and on whom will the research have an impact? The research will impact healthcare professionals', especially nurses', future educational standards and ultimately patients.Reporting MethodPRISMA extension for scoping reviews.No patient or public contributionNot required as it was a literary work (scoping review).
Diurnal changes in apoplast bypass flow of water and ions in salt‐stressed wheat (Triticum aestivum L.) and barley (Hordeum vulgare L.)
Authors: Lu Yingying , Fricke Wieland 
Published: June 2023

AbstractThe aim of the present study was to quantify the contribution of apoplastic bypass flow to the uptake of water and salt across the root cylinder of wheat and barley during day and night. Plants were grown on hydroponics until they were 14–17 days old and then analysed over a single day (16 h) or night (8 h) period while being exposed to different concentrations of NaCl (50, 100, 150 and 200 mM NaCl). Exposure to salt started just before the experiment (short‐term stress) or had started 6d before (longer‐term stress). Bypass flow was quantified using the apoplastic tracer dye 8‐hydroxy‐1,3,6‐pyrenesulphonic acid (PTS). The percent contribution of bypass flow to root water uptake increased in response to salt stress and during the night and amounted to up to 4.4%. Bypass flow across the root cylinder of Na+ and Cl− made up 2%–12% of the net delivery of these ions to the shoot; this percentage changed little (wheat) or decreased (barley) during the night. Changes in the contribution of bypass flow to the net uptake of water, Na+ and Cl− in response to salt stress and day/night are the combined result of changes in xylem tension, the contribution of alternative cell‐to‐cell flow path and the requirement to generate xylem osmotic pressure.
Consumption risk‐sharing under terror shocks: Evidence from value‐chain network rosters in Nigeria
Authors: Chuku Chuku , Ubabukoh Chisom 
Published: June 2023

AbstractHouseholds in Nigeria live in inherently risky environments; accentuated by the preponderance of terror incidences, banditry, and farmer–herder‐related clashes that are more concentrated in the northern than southern parts of the country. This study examines the proposition that households with a robust network roster—especially networks related to ethnicities and financial remittances from outside their communities—are better able to weather the idiosyncratic and aggregate impact of terror‐related shocks; and thus, experience less consumption variability to terror‐related shock than other similar households without the “insurance” of an external network. Our main empirical strategy applies a panel difference‐in‐differences specification to three waves of the LSMS‐ISA surveys for Nigeria. The results from the study indicate that having external networks outside the community is an important coping mechanism for terror‐related shocks, both for overall welfare and food consumption. The difference in consumption variability between groups with outside network “insurance” and those without could be as high as 20 percentage points. Thus, risk‐sharing arrangements for households should exploit outside network insurance mechanisms to mitigate welfare losses from terror‐related shocks.
‘I've probably risk assessed this myself’: Choice, control and participant co‐regulation in a disability individualised funding scheme
Authors: Yates Sophie , Dickinson Helen , West Raelene 
Published: June 2023

AbstractCo‐production is an intrinsic component of disability individualised funding schemes such as Australia's National Disability Insurance Scheme (NDIS). In this paper, we argue that an under‐explored facet of co‐production is the role that users of these services play in co‐regulation. We draw on data collected in a qualitative study exploring participants' use of providers who are not registered with the NDIS regulator, the Quality and Safeguards Commission. Employing Steiner et al.'s (2023) 5Ws framework, we focus particularly on the dimensions of what, why and where to understand the conditions underpinning client co‐regulation of quality and safety in the NDIS. We also explore the various types of activities participants engage in to co‐produce their NDIS services, highlighting activities designed to improve the quality and safety of services delivered by unregistered providers.
Standing Pelvic Tilt Is Associated With Dynamic Pelvic Tilt During Running When Measured by 3-Dimensional Motion Capture
Authors: Mach Madison S. , Ebersole Kyle T. , Ericksen Hayley E. , Nguyen Anh-Dung , Earl-Boehm Jennifer E. 
Published: June 2023

Standing pelvic tilt (PT) is related to biomechanics linked with increased risk of injury such as dynamic knee valgus. However, there is limited evidence on how standing PT relates to dynamic PT and whether the palpation meter (PALM), a tool to measure standing PT, is valid against 3-dimensional (3D) motion analysis. The purposes of this study were to (1) determine the criterion validity of the PALM for measuring standing PT and (2) identify the relationship between standing PT and dynamic PT during running. Participants (n = 25; 10 males and 15 females) had their standing PT measured by the PALM and 3D motion analysis. Dynamic PT variables were defined at initial contact and toe off. No relationship between the 2 tools was found. Significant large positive relationships between standing PT and PT at initial contact (r = .751, N = 25, P < .001) and PT at toe off (r = .761, N = 25, P < .001) were found. Since no relationship was found between standing PT measured by the PALM and 3D motion analysis, the PALM is not a valid alternative to 3D motion analysis. Clinicians may be able to measure standing PT and gain valuable information on dynamic PT, allowing clinicians to quickly assess whether further biomechanical testing is needed.
Prevalence and predictive modeling of undiagnosed diabetes and impaired fasting glucose in Taiwan: a Taiwan Biobank study
Authors: Chung Ren-Hua , Chuang Shao-Yuan , Chen Ying-Erh , Li Guo-Hung , Hsieh Chang-Hsun , Chiou Hung-Yi , Hsiung Chao A 
Published: June 2023

IntroductionWe investigated the prevalence of undiagnosed diabetes and impaired fasting glucose (IFG) in individuals without known diabetes in Taiwan and developed a risk prediction model for identifying undiagnosed diabetes and IFG.Research design and methodsUsing data from a large population-based Taiwan Biobank study linked with the National Health Insurance Research Database, we estimated the standardized prevalence of undiagnosed diabetes and IFG between 2012 and 2020. We used the forward continuation ratio model with the Lasso penalty, modeling undiagnosed diabetes, IFG, and healthy reference group (individuals without diabetes or IFG) as three ordinal outcomes, to identify the risk factors and construct the prediction model. Two models were created: Model 1 predicts undiagnosed diabetes, IFG_110 (ie, fasting glucose between 110 mg/dL and 125 mg/dL), and the healthy reference group, while Model 2 predicts undiagnosed diabetes, IFG_100 (ie, fasting glucose between 100 mg/dL and 125 mg/dL), and the healthy reference group.ResultsThe standardized prevalence of undiagnosed diabetes for 2012–2014, 2015–2016, 2017–2018, and 2019–2020 was 1.11%, 0.99%, 1.16%, and 0.99%, respectively. For these periods, the standardized prevalence of IFG_110 and IFG_100 was 4.49%, 3.73%, 4.30%, and 4.66% and 21.0%, 18.26%, 20.16%, and 21.08%, respectively. Significant risk prediction factors were age, body mass index, waist to hip ratio, education level, personal monthly income, betel nut chewing, self-reported hypertension, and family history of diabetes. The area under the curve (AUC) for predicting undiagnosed diabetes in Models 1 and 2 was 80.39% and 77.87%, respectively. The AUC for predicting undiagnosed diabetes or IFG in Models 1 and 2 was 78.25% and 74.39%, respectively.ConclusionsOur results showed the changes in the prevalence of undiagnosed diabetes and IFG. The identified risk factors and the prediction models could be helpful in identifying individuals with undiagnosed diabetes or individuals with a high risk of developing diabetes in Taiwan.
Improving the efficiency of virtual insulin teaching for patients admitted to hospital through the COVID-19 pandemic: a quality improvement initiative
Authors: Tong Jeffery , Meehan Rebecca , Iannicello Dane , Li Raymond , Joy Tisha , Spaic Tamara , Tung Tsan-Hua , Clemens Kristin K 
Published: June 2023

BackgroundThroughout the COVID-19 pandemic, many areas of medicine transitioned to virtual care. For patients with diabetes admitted to hospital, this included diabetes education and insulin teaching. Shifting to a virtual model of insulin teaching created new challenges for inpatient certified diabetes educators (CDE).ObjectiveWe advanced a quality improvement project to improve the efficiency of safe and effective virtual insulin teaching throughout the COVID-19 pandemic. Our primary aim was to reduce the mean time between CDE referral to successful inpatient insulin teach by 0.5 days.Design, setting, participantsWe conducted this initiative at two large academic hospitals between April 2020 and September 2021. We included all admitted patients with diabetes who were referred to our CDE for inpatient insulin teaching and education.InterventionAlongside a multidisciplinary team of project stakeholders, we created and studied a CDE-led, virtual (video conference or telephone) insulin teaching programme. As tests of change, we added a streamlined method to deliver insulin pens to the ward for patient teaching, created a new electronic order set and included patient-care facilitators in the scheduling process.Main outcome and measuresOur main outcome measure was the mean time between CDE referral and successful insulin teach-back. Our process measure was the percentage of successful insulin pen deliveries to the ward for teaching. As balance measures, we captured the percentage of patients with a successful insulin teach, the time between insulin teach and hospital discharge, and readmissions to hospital for diabetes-related complications.ResultsOur tests of change improved the efficiency of safe and effective virtual insulin teaching by 0.27 days. The virtual model appeared less efficient than usual in-person care.ConclusionsIn our centre, virtual insulin teaching supported patients admitted to hospital through the pandemic. Improving the administrative efficiency of virtual models and leveraging key stakeholders remain important for long-term sustainability.
First-line treatment of unresectable or metastatic HER2 positive esophagogastric adenocarcinoma: liquid biomarker analysis of the phase 2 INTEGA trial
Authors: Paschold Lisa , Stein Alexander , Thiele Benjamin , Tintelnot Joseph , Henkes Svenja-Sibylla , Coith Cornelia , Schultheiß Christoph , Pantel Klaus , Riethdorf Sabine , Binder Mascha 
Published: June 2023

BackgroundThe addition of nivolumab to trastuzumab and chemotherapy in first-line unresectable or metastatic HER2 positive esophagogastric adenocarcinoma (HER2+ EGA) results in long progression-free and overall survival as shown by the INTEGA (ipilimumab or FOLFOX in combination with nivolumab and trastuzumab in HER2 positive esophagogastric adenocarcinoma) trial. This trial suggested that the chemotherapy backbone is needed in an unselected HER2+ patient population. Yet, it remains an open question if there are specific patient subsets that may benefit from an enhanced immunotherapeutic but chemotherapy-free approach.MethodsWe analyzed blood T cell repertoire metrics determined by next-generation sequencing, circulating tumor cell (CTC) counts detected by CellSearch and their expression of HER2 and PD-L1 as potential liquid biomarkers predicting outcomes on ipilimumab versus FOLFOX (folinic acid, FOL, fluorouracil, F, oxaliplatin, OX) chemotherapy added to a backbone of trastuzumab and nivolumab in patients with HER2+ EGA in the INTEGA trial population.ResultsPatients with two out of three baseline-determined liquid biomarkers—high T cell repertoire richness, absence of CTCs or HER2-expression on CTCs—made up approximately 44% of HER2+ EGA cases and did not show compromise in efficacy if treated with a chemotherapy-free regimen. Long-term responders showing a progression-free survival of >12 months were enriched in this biomarker triad, especially if treated on the chemotherapy-free arm.ConclusionProspective validation of this liquid biomarker triad is needed to molecularly define HER2+ EGA patient subsets with different needs in the first-line systemic treatment setting.
Anomalocolax nemipteri gen. et sp. nov. (Copepoda, Cyclopoida, Bomolochidae) recovered from Nemipterus japonicus (Bloch, 1791) (Actinopterygii) in Japan
Authors: Izawa Kunihiko 
Published: June 2023

Abstract
Anomalocolax nemipteri gen. et sp. nov. is described based on a single specimen of the female recovered from the bucco-branchial cavity of the Japanese threadfin bream, Nemipterus japonicus (Bloch, 1792) (Nemipteridae) in Japan. This species is unique in the family in having one process on the first free segment of the antennule in addition to five plumose setae in the adult female.
On Pseudocypretta franki n. sp. (Ostracoda, Cyprididae) from Lake Sibaya, South Africa
Authors: Ferreira Vitor Góis , Higuti Janet , Martens Koen 
Published: June 2023

Abstract
Pseudocypretta franki n. sp. is described from Lake Sibaya in South Africa. This is the first African species of the genus, which has two further Asian and one South American species. Clearly, the genus has a much wider distribution than originally thought and it is postulated that further species could be found in zoogeographical regions from where it is presently unknown. Pseudocypretta franki n. sp. differs from its congeners in the much larger overlap of the right valve by the left valve along anterior, ventral and posterior sides, and by the shape of the valves both in dorsal and in lateral views. The new species lacks the caudal rami, just as in the South American P. amor, whereas both Asian species do have Cypridopsinae-type reduced caudal rami.
The Historical School and German International Legal Thought in the 19th Century
Authors: von Bernstorff Jochen , Mayer Max 
Published: June 2023

Abstract
This article traces the influence of the German Historical School of Law around Friedrich Carl von Savigny has had on various fundamental concepts of international law during the 19th and into the beginning of the 20th century in a detailed manner. During this time, the Historical School’s radical reformulation of the notion of law as a peoples’ spiritual essence unfolding through its habitual social action allowed 19th century scholars to redefine international law as customary law and, together with notably Hegelian teleological thought, laid conceptual groundwork for the integration of themes of European cultural superiority into the doctrines and philosophy of international law. Its conceptual legacy can further be traced in the later German positivism à la Jellinek or Oppenheim with its theories on ‘common civilised consent’ as foundation of international law.
The Strategy of Strengthening the Country Through Higher Education in China: a Historical Policy Perspective
Authors: Li Kun , Li Jian 
Published: June 2023

Abstract
The strategy of strengthening the country through higher education in China concentrates on building a stronger higher education country is the necessary requirement for implementing the strategy of strengthening the country with talents and enhancing our overall national strength and international competitiveness. Building a strong country in higher education is an inevitable requirement for strengthening the ability of independent innovation and building an innovative country. Building a strong country in higher education is an inevitable requirement for building an advanced socialist culture and promoting the great development and prosperity of culture. In addition, this study also put forward the ideological route and strategic focus of the construction of higher education power.
Modernization of Higher Education Governance in China: Contexts and Ideas
Authors: Li Jian , Wei Yukai 
Published: June 2023

Abstract
The governance of higher education in China is a systematic project. Only by coordinating various systems can we build a scientific and reasonable national higher education governance system and comprehensively improve the governance capacity and performance of the country. To achieve this general goal, we need to promote overall progress and key breakthroughs, strengthen the combination of top-level design and correctly handle the relationship between the state and society, government, and market, central and local, government administration and public participation, economic efficiency, and social equity on the basis of the rule of law.
Use of mobile applications and health technologies among dementia caregivers with chronic conditions: A cross-sectional study
Authors: Mendez Kyra Jennifer Waligora , Labrique Alain Bernard , Budhathoki Chakra , Sadak Tatiana , Tanner Elizabeth K. , Cotter Valerie T. , Han Hae-Ra 
Published: June 2023

Objective Almost 80% of people, who are caring for someone with dementia, have one or more chronic conditions and require self-management support. New technologies offer promising solutions; however, little is known about what technologies caregivers use for their health or in general. This study aimed to describe the prevalence of mobile application (app) and health-related technology use among caregivers who have chronic conditions and care for someone with dementia. Methods A cross-sectional study was conducted with 122 caregivers recruited online and from communities in the Baltimore-metropolitan area. Data were collected with online surveys and computer-assisted telephone interviews. Descriptive and inferential statistics were used to analyze survey data. Results Study participants were primarily female (95 of 122, 77.9%), middle-aged (average 53 years, standard deviation (SD) 17), well educated (average 16 years, SD 3.3), an adult child of the person with dementia (53 of 122, 43.4%), and had 4 chronic conditions on average (SD 2.6). Over 90% of caregivers used mobile apps (116 of 122), spending a range of 9 to 82 min on each app. Most caregivers reported using social media apps (96 of 116, 82.8%), weather apps (96 of 116, 82.8%), and/or music or entertainment apps (89 of 116, 76.7%). Among caregivers using each app type, more than half of caregivers used social media (66 of 96, 69%), games (49 of 74, 66%), weather (62 of 96, 65%), and/or music or entertainment apps (51 of 89, 57%) daily. Caregivers also used several technologies to support their own health—the most common being websites, mobile devices, and health-related mobile apps. Conclusion This study supports the feasibility of using technologies to promote health behavior change and support self-management among caregivers.
Allelic variation of KIR and HLA tunes the cytolytic payload and determines functional hierarchy of NK cell repertoires
Authors: Philippon Camille , Tao Sudan , Clement Dennis , Haroun-Izquierdo Alvaro , Kichula Katherine M. , Netskar Herman , Brandt Ludwig , Oei Vincent Sheng , Kanaya Minoru , Lanuza Pilar Maria , Schaffer Marie , Goodridge Jodie P. , Horowitz Amir , Zhu Faming , Hammer Quirin , Sohlberg Ebba , Majhi Rakesh Kumar , Kveberg Lise , Önfelt Björn , Norman Paul J. , Malmberg Karl-Johan 
Published: June 2023

Abstract
The functionality of natural killer (NK) cells is tuned during education and is associated with remodeling of the lysosomal compartment. We hypothesized that genetic variation in killer cell immunoglobulin-like receptor (KIR) and HLA, which is known to influence the functional strength of NK cells, fine-tunes the payload of effector molecules stored in secretory lysosomes. To address this possibility, we performed a high-resolution analysis of KIR and HLA class I genes in 365 blood donors and linked genotypes to granzyme B loading and functional phenotypes. We found that granzyme B levels varied across individuals but were stable over time in each individual and genetically determined by allelic variation in HLA class I genes. A broad mapping of surface receptors and lysosomal effector molecules revealed that DNAM-1 and granzyme B levels served as robust metric of the functional state in NK cells. Variation in granzyme B levels at rest was tightly linked to the lytic hit and downstream killing of major histocompatibility complex–deficient target cells. Together, these data provide insights into how variation in genetically hardwired receptor pairs tunes the releasable granzyme B pool in NK cells, resulting in predictable hierarchies in global NK cell function.