bluuebunny/crossref_metadata_2025_split huggingface dataset:
Of mice and men: Dendritic architecture differentiates human from mice neuronal networks
Authors: Kanari Lida , Shi Ying , Arnaudon Alexis , Barros-Zulaica Natalí , Benavides-Piccione Ruth , Coggan Jay S. , DeFelipe Javier , Hess Kathryn , Mansvelder Huib D. , Mertens Eline J. , Meystre Julie , de Campos Perin Rodrigo , Pezzoli Maurizio , Daniel Roy Thomas , Stoop Ron , Segev Idan , Markram Henry , de Kock Christiaan P.J. 
Published: September 2023

AbstractThe organizational principles that distinguish the human brain from other species have been a long-standing enigma in neuroscience. Focusing on the uniquely evolved human cortical layers 2 and 3, we computationally reconstruct the cortical architecture for mice and humans. We show that human pyramidal cells form highly complex networks, demonstrated by the increased number and simplex dimension compared to mice. This is surprising because human pyramidal cells are much sparser in the cortex. We show that the number and size of neurons fail to account for this increased network complexity, suggesting that another morphological property is a key determinant of network connectivity. Topological comparison of dendritic structure reveals much higher perisomatic (basal and oblique) branching density in human pyramidal cells. Using topological tools we quantitatively show that this neuronal structural property directly impacts network complexity, including the formation of a rich subnetwork structure. We conclude that greater dendritic complexity, a defining attribute of human L2 and 3 neurons, may provide the human cortex with enhanced computational capacity and cognitive flexibility.Graphical abstractA. A multiscale analysis was performed to compare the mouse and human brains: from the anatomical properties of brain regions to the morphological details of single neurons. B. Human circuits are larger than mice in terms of size and number of neurons, but present decreased neuron density, resulting in increased distances between neurons, particularly among pyramidal cells. C. Greater network complexity emerges within the human brain. Network complexity is defined by larger groups of neurons forming complex interconnections throughout the network. D. The topological analysis of layer 2/3 pyramidal cells in the temporal cortex reveals an intriguing difference: human neurons exhibit a significantly larger number of dendritic branches, especially near the cell body compared to mice. This phenomenon is termed ”higher topological complexity” in dendrites. Our findings suggest that dendritic complexity wields a more substantial influence on network complexity than neuron density.
Childhood maltreatment and subsequent risk of hospitalization or death due to COVID-19: a cohort study in the UK Biobank
Authors: Wang Yue , Ge Fenfen , Aspelund Thor , Ask Helga , Hauksdóttir Arna , Hu Kejia , Jakobsdóttir Jóhanna , Zoega Helga , Shen Qing , Whalley Heather C , Vesterager Pedersen Ole Birger , Lehto Kelli , Andreassen Ole A , Fang Fang , Song Huan , Valdimarsdóttir Unnur A 
Published: September 2023

AbstractChildhood maltreatment has been associated with some infection-related outcomes, yet its potential role in severe COVID-19 outcomes has not been addressed. Therefore, leveraging longitudinal data from the population-based UK Biobank (N=151,427), our study aimed to explore the association between childhood maltreatment and severe COVID-19 outcomes (i.e., hospitalization or death due to COVID-19) and its underlying mechanisms. Our resultssuggestthat childhood maltreatment, particularly physical neglect, is associated with a 54.0% increased risk of severe COVID-19 outcomes (i.e., hospitalization or death due to COVID-19), which was not modified by genetic predisposition to severe COVID-19 outcomes.Wefound that 50.9% of this association was mediated by suboptimal socioeconomic status, lifestyle and prepandemic somatic diseases or psychiatric disorders. These findings highlight the role of early life adversities in severe health consequences across the lifespan and call for increased clinical surveillance of people exposed to childhood maltreatment in COVID-19 outbreaks and future pandemics.
The variation of malaria prevention measures knowledge and their associated factors: A cross-sectional study in East Nusa Tenggara Province Indonesia
Authors: Guntur Robertus Dole , Kleden Maria A. , Kusumaningrum Damai , Amirul Islam Fakir M 
Published: September 2023

AbstractObjectiveMalaria is one of the major public health problems in African and Southeast Asian countries including Indonesia. However, knowledge of malaria prevention measures (MPM) is not well studied, particularly in Indonesia. This study aimed to investigate the level of MPM knowledge and associated factors among rural adults in high, moderate and low endemic settings of East Nusa Tenggara Province (ENTP) Indonesia.MethodsA community-based cross-sectional study was conducted among a randomly selected 1495 households at rural ENTP. Multistage sampling technique was employed to recruit participants. Univariate and multivariable logistic regression model was used to assess factors affecting knowledge of MPM.ResultsThe level of MPM knowledge in low, moderate, and high endemic settings differs significantly with the highest in low settings (57%, 95% CI: 50.5 – 63.5 and the lowest in high settings (19.3%, 95% CI: 11.1 – 27.5). In all settings, good level of MPM knowledge was significantly higher for adults with high SES (Adjusted odds ratio (AOR) = 2.52, 95% CI: 1.20 – 5.30; AOR=20.5,95%CI: 4.64-90.8, AOR=3.31,95%CI: 1.34-8.15 respectively) compared to those having low SES. In high and moderate settings, the likelihood of good MPM knowledge was considerately higher for adults with at least secondary (AOR=2.35, 95% CI= 1.29 – 4.36, AOR=2.66, 95% CI=1.32-5.39 respectively) than those with primary or no education level.ConclusionsThe good level of MPM knowledge was very low in three different malaria endemic settings. Higher level of education and high SES were significantly associated with the good level. Therefore, health education promotion on MPM knowledge is critical to support malaria elimination program in the province.
The neonatal gut microbiota: a role in the encephalopathy of prematurity
Authors: Vaher Kadi , Blesa Cabez Manuel , Parga Paula Lusarreta , Binkowska Justyna , van Beveren Gina J , Odendaal Mari-Lee , Sullivan Gemma , Stoye David Q , Corrigan Amy , Quigley Alan J , Thrippleton Michael J , Bastin Mark E , Bogaert Debby , Boardman James P 
Published: September 2023

SummaryPreterm birth associates with atypical brain development and neurocognitive impairment. The gut microbiome is implicated in neurobehavioural outcomes of typically developing infants and children, but its relationship with neurodevelopment in preterm infants is unknown. We characterised the faecal microbiome in a cohort of 147 neonates enriched for very preterm birth (<32 weeks’ gestation) using 16S-based and shotgun metagenomic sequencing. Delivery mode had the strongest association with preterm microbiome shortly after birth; low birth gestational age, infant sex and antibiotics significantly associated with microbiome composition at NICU discharge. Thereafter, we integrated these data with term-equivalent structural and diffusion brain MRI. Bacterial community composition associated with MRI features of encephalopathy of prematurity. Particularly, abundances ofEscherichia coliandKlebsiellaspp. correlated with microstructural parameters in deep and cortical grey matter. Metagenome functional capacity analyses suggested that these bacteria may interact with brain microstructural development via tryptophan and propionate metabolism. This study indicates that gut microbiome associates with brain development following preterm birth.
The exogenous application of the apocarotenoid retinaldehyde negatively regulates auxin-mediated root growth
Authors: Xu Kang , Zeng Haoran , Lin Feiyang , Yumoto Emi , Asahina Masashi , Hayashi Ken-ichiro , Fukaki Hidehiro , Ito Hisashi , Watahiki Masaaki K. 
Published: September 2023

AbstractRoot development is essential for plant survival. The lack of carotenoid biosynthesis in thephytoene desaturase 3(pds3) mutant results in short primary roots (PR) and reduced lateral root (LR) formation. In this study, we show that short-term inhibition of PDS by fluridone suppressed PR growth in WT, but to a lesser extent in auxin mutants. Such an inhibition of PDS activity increased endogenous indole-3-acetic acid (IAA) levels, promoted auxin signaling, and partially complemented the PR growth of auxin deficient mutant,YUCCA 3 5 7 8 9quadruple mutant (yucQ). The exogenous application of retinaldehyde (retinal), an apocarotenoid derived from β-carotene, complemented the fluridone-induced suppression of root growth, as well as the short roots of thepds3mutant. Retinal also partially complemented the auxin-induced suppression of root growth. These results suggest that retinal may play a role in regulating root growth by modulating endogenous auxin levels.One-sentence summaryThe short-term inhibition of carotenoid biosynthesis mediates the production of β-carotene-derived apocarotenoid retinal which negatively regulates auxin levels and signaling to control root growth.
Sterol 3-beta-Glucosyltransferase TRANSPARENT TESTA15 Controls Seed Development and Flavanol Accumulation through its Role in Vacuole Biogenesis and Maintenance in Arabidopsis
Authors: Akary Elodie , Berger Adeline , Perreau François , Frey Anne , To Alexandra , Citerne Sylvie , Schaller Hubert , Vernhettes Samantha , Grandjean Olivier , Nesi Nathalie , Marion-Poll Annie , Lepiniec Loïc , Debeaujon Isabelle 
Published: September 2023

ABSTRACTThe Arabidopsis sterol 3-beta-glucosyltransferase UGT80B1/TRANSPARENT TESTA15 (TT15) catalyzes sterol glucoside biosynthesis. Its loss of function causes reduced seed size, defective flavanol, polysaccharide and lipid polyester deposition at the seed coat and reduced seed dormancy. How TT15 controls seed development and physiology is unknown. Here we show thattt15mutants exhibit seed lethality with incomplete penetrance and maternal determinism that is correlated with endosperm cellularization defects, together with an increased sensitivity of seed germination to exogenous abscisic acid and paclobutrazol. We also reveal that flavanol deposition in the vacuole duringtt15seed development triggers premature endothelium cell death. An autoimmune-like syndrome characterized by callose and H2O2accumulation was detected in endothelium at the seed abaxial pole. Similar phenotypes were observed withtt9/gfs9,a mutant defective in endomembrane trafficking and homotypic vacuole fusion. Double mutant analysis showed thattt9partially rescuedtt15endothelium phenotypes. Consistent with seed mutant phenotypes,TT15promoter activity was detected in endothelium and endosperm and TT15 protein was located mainly at the vacuolar membrane (tonoplast). Using fluorescence recovery after photobleaching, we demonstrated that tonoplast fluidity was increased intt15roots. Altogether our data suggest that TT15 regulates seed development and flavanol accumulation by modulating vacuole biogenesis and maintenance.
Impacts of ethical leadership, innovative climate on project success: the role of innovative behavior and time pressure
Authors: Tran Pham Toan Khanh , Nguyen Le To Quyen Hoang Thuy 
Published: September 2023

PurposeThis study aims to explore how ethical leadership and innovative climate impact project success through employees innovative behavior. In addition, based on the conservation of resources theory, this study also examines whether time pressure moderates the innovative work behavior and project success nexus.Design/methodology/approachData were collected from 403 employees working in Vietnam's information technology (IT) companies. The partial least squares structural equation modeling was used to investigate the impact of ethical leadership and innovative climate on project success, the mediating effect of innovative behavior and the moderating role of time pressure.FindingsEmpirical findings indicate that ethical leadership and innovative climate positively impact on project success. Moreover, employees' innovative behavior has a complementary effect on these relationships. In addition, time pressure moderates the nexus between innovative work behavior and project success.Practical implicationsThe findings suggest that IT companies can promote innovative work behavior among employees by building ethical leadership and enhancing an innovative climate. Moreover, when designing and implementing a project, project managers should take care to allow enough time for innovative behavior within the team.Originality/valueThis inquiry is probably the first attempt to explore the mechanism linking ethical leadership and innovative climate to project success, with the mediating role of employees' innovative behavior. Additionally, time pressure is an increasingly relevant factor in contemporary business, but so far little explored in research. This study extends the current knowledge by considering the moderating role of time pressure in the innovative behavior and project success nexus.
How does platform certification affect the marketing performance of sellers in food e-commerce? Interaction with reputation mechanisms
Authors: Xue Hu , Jin Shanshan , Wu Qianrong , Geng Xianhui 
Published: September 2023

PurposePlatform certification constitutes an effective mechanism for managing the lemon problem concerning food e-commerce. This work aims to evaluate the market effect of platform certification and analyzes its correction mechanism for lemon problem combined with reputation mechanism.Design/methodology/approachUtilizing the Gold Seller certification of Taobao.com to serve as an illustration, the authors conducted an empirical study based on the sales data of hairy crabs among 2,239 sample sites over six points in time from October to December 2019, systematically examining the market effect of food e-commerce platform certification along with the interaction between food e-commerce platform certification and reputation mechanisms, followed by a heterogeneity test by product price.FindingsThis study finds that sellers with platform certification can significantly increase their sales. The market effect of platform certification is more easily observed in the low-price product market. In addition, platform certification and reputation mechanisms have complementary effects. In a low-price product market, the complementary effect of platform certification and product reputation diminishes, while the complementary effect of platform certification and seller reputation disappears.Originality/valueThis study explores the market effect of food e-commerce platform certification, reveals the market effect of certification mechanism when multiple signaling mechanisms exist simultaneously and conducts an empirical test based on real market data. It provides a better comprehension of how platform certifications work in food e-commerce.
Integrating blockchain with building information modelling (BIM): a systematic review based on a sociotechnical system perspective
Authors: Yu Jiyang , Zhong Hua , Bolpagni Marzia 
Published: September 2023

Purpose
The purpose of this paper is to analyse the current state of research on the integration of blockchain and building information modelling (BIM) in the Architecture, Engineering, Construction and Operations (AECO) industry as a means of identifying gaps between the existing paradigm and practical applications for determining future research directions and improving the industry. The study aims to provide clear guidance on areas that need attention for further research and funding and to draw academic attention to factors beyond the technical dimension.

Design/methodology/approach
A mixed-method systematic review is used, considering multiple literature types and using a sociotechnical perspective-based framework that covers three dimensions (technic, process and context) and three research elements (why, what and how). Data are retrieved and analysed from the Web of Science and Scopus databases for the 2017–2023 period.

Findings
While blockchain has the potential to address security, traceability and transparency and complement the system by integrating supporting applications, significant gaps still exist between these potentials and widespread industry adoption. Current limitations and further research needs are identified, including designing fully integrated prototypes, empirical research to identify operational processes, testing and analysing operational-level models or applications and developing and applying a technology acceptance model for the integration paradigm. Previous research lacks contextual settings, real-world tests or empirical investigations and is primarily conceptual.

Originality/value
This paper provides a comprehensive, critical systematic review of the integration of blockchain with BIM in the construction industry, using a sociotechnical perspective-based framework which can be applied in future reviews. The study provides insight into the current state and future opportunities for policymakers and practitioners in the AECO industry to prepare for the transition in this disruptive paradigm. It also provides a phased plan along with a clear direction for the transition to more advanced applications.
The impact of business ethics on stress, anxiety and depression and the success of auditors
Authors: Al-Ameedee Saif Mahdi Muslim , Moradi Mahdi , Salehi Mahdi 
Published: September 2023

Purpose
Ethical concerns in the field of trade and business and research efforts in the area of management and implementation of ethical standards in the organizational chain in the current situation, mainly due to the impact on the performance and procedures of organizations, and, finally, the effect on the views and attitudes of stakeholders and users of corporate information have become critical. Therefore, this study aims to investigate the impact of business ethics on stress, anxiety and depression and the success of auditors in Iran and Iraq.

Design/methodology/approach
The study’s statistical population includes all partners, managers and auditors working in auditing firms. Three hundred sixty-five questionnaires were completed by Iranian respondents and 250 questionnaires by Iraqi respondents in 2021. Also, the analysis of variance and regression of ordinary least squares have been used for data analysis and testing of hypotheses.

Findings
The research results show a negative and significant relationship between the results of business ethics and stress, anxiety and depression of auditors in Iran and Iraq and a positive relationship between business ethics and auditors’ success in Iran and Iraq.

Originality/value
As the current research was conducted in emerging financial markets such as Iran and Iraq, which are highly competitive, along with special economic conditions, and as the occupation of the ISIS terrorist group, the civil wars in Iraq, the world’s severe economic sanctions against Iran and following the global crisis of COVID-19, both countries have had special conditions. Therefore, the current research can bring helpful information to the readers and help everyone develop science and knowledge in this field.
Effects of work interruption on employees' work performance: moderating role of social media usage
Authors: Ma Liang , Zhang Xin 
Published: September 2023

PurposeWork interruptions (WIs) due to social media are becoming more and more common in the daily lives of organizations. However, the relationship between WI and work performance of employees is still unclear. This study aims to investigate the effects of WIs due to social media on employees' work performance in terms of different mechanisms; it also considers the moderating role of social media usage.Design/methodology/approachUsing the jobs demands-resource (JD-R) model, this paper proposes a research model to investigate the effects of WIs on employee work performance from the perspective of the enabling mechanism and burden mechanism. Structural equation modeling (SEM) was used to analyze the data of 444 employees.FindingsThe results show that (1) with regard to the enabling mechanism path, WI has a positive effect on employees' sense of belonging, which further has a positive effect on employees' work performance; (2) with regard to the burden mechanism path, WI has a positive effect on employees' interruption overload; however, the effect of employee interruption overload on employees' work performance is not significant, and (3) social media used for either work or social purposes can strengthen the relationship between WI and interruption overload, while social media used for work-related purposes can reduce the relationship between WI and a sense of belonging.Originality/valueFirst, this paper contributes to the WI literature by clarifying how WI affects employees' work performance through different mechanisms, namely the enabling mechanism and the burden mechanism. Second, this paper contributes to the WI literature by revealing a boundary condition, namely social media use, between WI and a sense of belonging and between WI and employees' interruption overload.
Trust but verify: the effect of religiosity and social conformity on verification of content shared via social media
Authors: Khalil Ashraf , Abdallah Salam , Hijazi Rafiq , Sheikh Kundan 
Published: September 2023

PurposeThis study aims to understand the patterns of content-sharing behaviour on major social media platforms by young adult users with reference to how these sharing patterns are influenced by two main sociocultural factors in their lives, religiosity and social conformity.Design/methodology/approachOnline surveys including both the ATSCI test for social conformity as well as the Hoge test for religiosity were filled out by 590 participants. In-depth interviews with six participants representative of the same population were conducted to deepen analysis of key variables explored in the surveys. The design of the interviews was semi-structured, whereby the focus was to achieve a general overview of participants' intentions and habits regarding sharing information via social media.FindingsThe findings show a significant positive impact of religiosity and social conformity on users' sharing intention which, in turn, affects their inclination towards verifying the content they share.Social implicationsThe authors' findings emphasise how users bear the onus of correcting the online information space. It paves the way for future research by recognising the value of independent corroboration amongst users.Originality/valueThis study lends key support to the growing body of research on social media use in societies in which shared religious and cultural values tend to clearly impact everyday social interaction.