bluuebunny/crossref_metadata_2025_split huggingface dataset:
The impact of unproved reserve news on the energy stock volatility: an empirical investigation on Turkey
Authors: Arzova Sabri Burak , Koy Ayben , Şahin Bertaç Şakir 
Published: March 2023

PurposeThis study investigates the effect of unproven energy reserve news on the volatility of energy firms' stocks. Thus, investors' perception of unproven energy reserves is revealed. Additionally, the study aims to determine whether the effect of the news changes according to time and volatility level.Design/methodology/approachThe general autoregressive conditional heteroskedasticity (GARCH) and exponential generalized autoregressive conditional heteroskedasticity (EGARCH) models consist of the energy reserve exploration news in Turkey for the period 2009–2022 and the volatility of 14 energy stocks.FindingsThe results indicate energy exploration news's negative and significant effect on volatility. According to empirical results, energy stock volatility is most affected in the first ten days. Besides, the results show that the significant models of energy reserve news in low-volatility stocks are proportionally higher than in high-volatility stocks.Research limitations/implicationsOnly unproved reserve news is included in the analysis, as sufficient confirmed reserves could not be reached during the sampling period. Further studies can compare proven and unproved reserve news effects. Additionally, a similar analysis can be conducted between Turkey and another country with a similar socio-economic character to examine different investor behaviors.Practical implicationsThis research includes indications on managing investors' reactions to unproven energy reserve news.Originality/valueThis study contributes to the literature by analyzing unproven reserves. Contrary to previous studies, examining stock volatility also makes the study unique.
The meaning of being a social entrepreneur in the society of multiple transitions
Authors: Vidovic Davorka 
Published: March 2023

Purpose
The purpose of this paper is to critically evaluate the meaning of being a social entrepreneur in a society marked with multiple transitions. It aims to understand how theoretical concepts of social entrepreneurs, including common dichotomies between economic and social, collective and individual, reflect in social entrepreneurs’ rationale, values and identities.

Design/methodology/approach
The study used an exploratory and qualitative approach. Empirical data were gathered during 14 semi-structured interviews with Croatian social entrepreneurs. Thematic analysis was used as an analytical framework.

Findings
The findings suggest complexity of social entrepreneurs’ rationale and identities as they face challenges in balancing different goals. Democratic and participative governance appeared to be the weakest link of social enterprises. Identity of social entrepreneurs in the society of multiple transitions is fluid and changes through the continuum from pure social to pure commercial, from more related to civil society to more related to the market, from mostly individual to mostly collective.

Research limitations/implications
The main limits of the study are related to sampling strategy and the small sample size. Generalization is limited by the nature of qualitative research and relies on analytical and naturalistic generalization.

Practical implications
The findings of the study may contribute to ecosystem development that would be more suitable for social enterprise realities in a specific context.

Originality/value
This paper focuses on the individual level and provides rare insights into social entrepreneurs’ rationale, values and identities.
Is your working life good? Alienation in the nexus between job characteristics and organizational citizenship behavior of hospitality frontline employees
Authors: Chen Kaung-Hwa , Ye Ying 
Published: March 2023

Purpose
This study motivated by humanistic care aims to identify hospitality frontline employees’ alienation in Taiwan during the COVID-19 pandemic, and based on the job demands-resources (JD-R) model, the mediating role of alienation between job characteristics and organizational citizenship behavior (OCB) is discussed.

Design/methodology/approach
The authors drew on the JD-R model to delineate the mechanisms by which job demands (including emotional dissonance and work–home conflict) and job resources (including job support, training and possibility for career development) affect OCB through employees’ alienation. This study adopted snowball sampling and purposive sampling to conduct a questionnaire survey aimed at Taiwanese hospitality frontline employees. A total of 373 valid questionnaires were retained, and structural equation model was used to test the research hypotheses.

Findings
The results revealed that job demands of emotional dissonance and work–family conflict positively affect alienation; job resources of job support, training and possibility for career development negatively affect alienation; alienation negatively affects OCB; and alienation mediates the relationship between job characteristics and OCB fully.

Research limitations/implications
Considering that alienation plays a full mediating role between job characteristics and organizational outcomes, this study put forward specific suggestions on how to increase job resources and reduce job demands to weaken alienation and further improve organizational performance in management practices. And practical implications were provided to help hospitality human resource management deal with the issue of talents retention. In addition, “work authenticity” should be introduced as a mediator in the future research. “Work authenticity” reflects employees’ positive working life state and is the opposite of “alienation.” The effectiveness of employees’ positive and negative working life state in communicating job characteristics and organizational outcomes can be compared.

Originality/value
The specific alienation experience of hospitality frontline employees is defined. Moreover, by introducing the alienation theory, this study demonstrates the health impairment path of JD-R model and suggests that job characteristics affect OCB through the full mediation of alienation.
Applying deep learning to predict innovations in small and medium enterprises (SMEs): the dark side of knowledge management risk
Authors: Figueiredo Ronnie , Ferreira João J. , Camargo Maria Emilia , Dorokhov Oleksandr 
Published: March 2023

PurposeThis study aims to predict the dark side of knowledge management risk to innovation in Portuguese small and medium enterprises (SMEs). It examines the spinner innovation model factors of knowledge creation, knowledge transfer, private knowledge, public knowledge and innovation in uncertain environments.Design/methodology/approachThe authors developed a conceptual model to support the analysis. The survey data stemmed from a sample of 208 Portuguese SMEs in Portugal. The authors analyzed the primary data from thead hocsurvey using the data mining (deep learning) technique.FindingsThe research sets out and tests factors relevant to understanding how to predict innovation in uncertain business environments. This study identifies four factors fostering innovation in SMEs: knowledge creation, knowledge transfer, public knowledge management and private knowledge management. Knowledge creation showed the best return and presented the closest relationship with innovation.Originality/valueInnovation models generally measure the relationships between variables and their impacts on the economy (economic and regional development). Predictive models are considered in the literature as a gap to be filled, especially in an uncertain environment in the SME context.
Analysis of cytokine profiles in sera of single and multiple infantile hemangioma
Authors: Sakata Mariko , Kunimoto Kayo , Kawaguchi Ami , Inaba Yutaka , Kaminaka Chikako , Yamamoto Yuki , Kakimoto Nobuyuki , Suenaga Tomohiro , Tokuhara Daisuke , Jinnin Masatoshi 
Published: March 2023

AbstractInfantile hemangiomas (IH) are benign vascular tumors that are common in infancy. They vary in growth, size, location, and depth, and although most lesions are relatively small, approximately one fifth of patients have multiple lesions. Risk factors for IH include female sex, low birth weight, multiple gestation, preterm birth, progesterone therapy, and family history, but the mechanism that causes multiple lesions is unclear. We hypothesized that blood cytokines are involved as a cause of multiple IHs, and tried to prove this using sera and membrane arrays from patients with single and multiple IHs. Serum samples were obtained from five patients with multiple lesions and four patients with a single lesion, none of which had received any treatment. Serum levels of 20 cytokines were measured using human angiogenesis antibody membrane array. Four of the 20 cytokines (bFGF, IFN‐γ, IGF‐I, and TGF‐β1) were higher in the patients with multiple lesions than in those with single lesion, with statistically significant difference (p < 0.05). Notably, signal for IFN‐γ was evident in all cases with multiple IHs, but was absent in cases with single IH. Although not significant, there was mild correlation between IFN‐γ and IGF‐I (r = 0.64, p = 0.065), and between IGF‐I and TGF‐β1 (r = 0.63, p = 0.066). bFGF levels were strongly and significantly correlated with the number of lesions (r = 0.88, p = 0.0020). In conclusion, blood cytokines could act as a cause of multiple IHs. This is a pilot study with a small cohort, so further large‐scale studies are necessary.
An innovative transfer DNA experimental design and qPCR assay: Protocol and pilot study
Authors: McCrane Samantha M. , Mulligan Connie J. 
Published: March 2023

AbstractForensic “touch” DNA samples are low‐quantity samples that are recovered from surfaces that have been touched by single or multiple individuals. These samples can include DNA from primary contributors who directly touched the surface, as well as secondary contributors whose DNA was transferred to the surface through an intermediary. It is difficult to determine the type of transfer, or how often and under what conditions DNA transfer occurs. In this paper, we present an innovative protocol that combines (1) a paired male and female transfer DNA experimental design in which the presence of male DNA indicates secondary transfer and (2) a cost‐effective quantitative PCR (qPCR) assay of a sex‐specific region in the Amelogenin gene to detect male and female DNA. We evaluate the ability of the Amelogenin qPCR assay to detect low concentrations of male and female DNA in mixed samples. We also test experimental DNA samples using our transfer DNA protocol to differentiate primary and secondary DNA transfer. Male DNA was detected in the majority of known mixed samples, even in samples with 4× more female DNA—this result demonstrates the ability to detect low concentrations of male DNA and the presence of secondary transfer DNA in our experimental design. Primary DNA transfer was detected in 100% of our experimental trials and secondary DNA transfer was detected in 37.5% of trials. Our innovative protocol mimics realistic case scenarios to establish rates of primary and secondary DNA transfer in an inexpensive and simplified manner.
Inhibitory effect of Schisandrin on the pharmacokinetics of poziotinib in vivo and in vitro by UPLC‐MS/MS
Authors: Wang Shuanghu , Xia Mengming , Wang Yu , Lu Zebei , Geng Peiwu , Dai Dapeng , Zhou Yunfang , Wu Qingjun 
Published: March 2023

AbstractBackgroundAs a pan‐HER tyrosine kinase inhibitor with a promising application prospect, poziotinib is likely to be coadministered with Schisandrins in clinical treatment due to its anticancer activities.MethodsEighteen Sprague–Dawley rats were randomly divided into three groups: Schisandrin A group and Schisandrin B group (20 mg/kg daily for 1 week), and control group (vehicle). On day 8, poziotinib (2 mg/kg) was administered by oral gavage 30 min later. An in vitro study was developed to identify the possible mechanisms of Schisandrins on poziotinib metabolism. All analytes were detected by UPLC/MS–MS, and molecular docking was performed by AutoDock Tools.ResultsWhen rats were preadministered with Schisandrin A, AUC(0−∞) and Cmax of poziotinib were obviously increased by 0.79‐ and 1.17‐fold, whereas the Vz/F and CLz/F values were dramatically decreased. The results in Schisandrin B group presented similarly. Both Schisandrin A and Schisandrin B were mixed inhibitors of poziotinib in RLMs, and Schisandrin B showed stronger inhibitory activity with IC50 values of 2.55 μM for M1 and 6.97 μM for M2. Molecular docking analysis demonstrated that Schisandrin A and Schisandrin B exhibited a strong binding ability towards CYP2D6 as compared to CYP3A4.ConclusionAll results provided the direct evidence of the pharmacokinetic drug–drug interactions (DDIs) between Schisandrin and poziotinib. Thus, particular attention should be paid when poziotinib is taken together with Schisandrins in clinical practice.
Immunotherapeutic approach to reduce senescent cells and alleviate senescence‐associated secretory phenotype in mice
Authors: Shrestha Niraj , Chaturvedi Pallavi , Zhu Xiaoyun , Dee Michael J. , George Varghese , Janney Christopher , Egan Jack O. , Liu Bai , Foster Mark , Marsala Lynne , Wong Pamela , Cubitt Celia C. , Foltz Jennifer A. , Tran Jennifer , Schappe Timothy , Hsiao Karin , Leclerc Gilles M. , You Lijing , Echeverri Christian , Spanoudis Catherine , Carvalho Ana , Kanakaraj Leah , Gilkes Crystal , Encalada Nicole , Kong Lin , Wang Meng , Fang Byron , Wang Zheng , Jiao Jin‐an , Muniz Gabriela J. , Jeng Emily K. , Valdivieso Nicole , Li Liying , Deth Richard , Berrien‐Elliott Melissa M. , Fehniger Todd A. , Rhode Peter R. , Wong Hing C. 
Published: March 2023

AbstractAccumulation of senescent cells (SNCs) with a senescence‐associated secretory phenotype (SASP) has been implicated as a major source of chronic sterile inflammation leading to many age‐related pathologies. Herein, we provide evidence that a bifunctional immunotherapeutic, HCW9218, with capabilities of neutralizing TGF‐β and stimulating immune cells, can be safely administered systemically to reduce SNCs and alleviate SASP in mice. In the diabetic db/db mouse model, subcutaneous administration of HCW9218 reduced senescent islet β cells and SASP resulting in improved glucose tolerance, insulin resistance, and aging index. In naturally aged mice, subcutaneous administration of HCW9218 durably reduced the level of SNCs and SASP, leading to lower expression of pro‐inflammatory genes in peripheral organs. HCW9218 treatment also reverted the pattern of key regulatory circadian gene expression in aged mice to levels observed in young mice and impacted genes associated with metabolism and fibrosis in the liver. Single‐nucleus RNA Sequencing analysis further revealed that HCW9218 treatment differentially changed the transcriptomic landscape of hepatocyte subtypes involving metabolic, signaling, cell‐cycle, and senescence‐associated pathways in naturally aged mice. Long‐term survival studies also showed that HCW9218 treatment improved physical performance without compromising the health span of naturally aged mice. Thus, HCW9218 represents a novel immunotherapeutic approach and a clinically promising new class of senotherapeutic agents targeting cellular senescence‐associated diseases.
Necroptosis inhibition counteracts neurodegeneration, memory decline, and key hallmarks of aging, promoting brain rejuvenation
Authors: Arrázola Macarena S. , Lira Matías , Véliz‐Valverde Felipe , Quiroz Gabriel , Iqbal Somya , Eaton Samantha L. , Lamont Douglas J. , Huerta Hernán , Ureta Gonzalo , Bernales Sebastián , Cárdenas J. César , Cerpa Waldo , Wishart Thomas M. , Court Felipe A. 
Published: March 2023

AbstractAge is the main risk factor for the development of neurodegenerative diseases. In the aged brain, axonal degeneration is an early pathological event, preceding neuronal dysfunction, and cognitive disabilities in humans, primates, rodents, and invertebrates. Necroptosis mediates degeneration of injured axons, but whether necroptosis triggers neurodegeneration and cognitive impairment along aging is unknown. Here, we show that the loss of the necroptotic effector Mlkl was sufficient to delay age‐associated axonal degeneration and neuroinflammation, protecting against decreased synaptic transmission and memory decline in aged mice. Moreover, short‐term pharmacologic inhibition of necroptosis targeting RIPK3 in aged mice, reverted structural and functional hippocampal impairment, both at the electrophysiological and behavioral level. Finally, a quantitative proteomic analysis revealed that necroptosis inhibition leads to an overall improvement of the aged hippocampal proteome, including a subclass of molecular biofunctions associated with brain rejuvenation, such as long‐term potentiation and synaptic plasticity. Our results demonstrate that necroptosis contributes to age‐dependent brain degeneration, disturbing hippocampal neuronal connectivity, and cognitive function. Therefore, necroptosis inhibition constitutes a potential geroprotective strategy to treat age‐related disabilities associated with memory impairment and cognitive decline.
The presymptomatic treatment with 3HFWC nanosubstance decreased plaque load in 5XFAD mouse model of Alzheimer's disease
Authors: Perovic Milka , Ciric Jelena , Matovic Valentina , Srbovan Maja , Koruga Djuro , Kanazir Selma , Ivkovic Sanja 
Published: March 2023

AbstractIntroductionIn the present study, we assessed the effects of the hyper‐harmonized‐hydroxylated fullerene–water complex (3HFWC) on Alzheimer's disease (AD) neuropathological hallmarks in 5XFAD mice, an AD animal model.MethodsThe 3‐week‐old 5XFAD mice were exposed to 3HFWC water solution ad libitum for 3 months in the presymptomatic phase of pathology. The functional effects of the treatment were confirmed through near‐infrared spectroscopy (NIRS) analysis through machine learning (ML) using artificial neural networks (ANNs) to classify the control and 3HFWC‐treated brain tissue samples. The effects of 3HFWC treatment on amyloid‐β (Aβ) accumulation, plaque formation, gliosis, and synaptic plasticity in cortical and hippocampal tissue were assessed.ResultsThe 3HFWC treatment significantly decreased the amyloid‐β plaque load in specific parts of the cerebral cortex. At the same time, 3HFWC treatment did not induce the activation of glia (astrocytes and microglia) nor did it negatively affect synaptic protein markers (GAP‐43, synaptophysin, and PSD‐95).ConclusionThe obtained results point to the potential of 3HFWC, when applied in the presymptomatic phase of AD, to interfere with amyloid plaque formation without inducing AD‐related pathological processes such as neuroinflammation, gliosis, and synaptic vulnerability.
When Naïve Pedagogy Breaks Down: Adults Rationally Decide How to Teach, but Misrepresent Learners’ Beliefs
Authors: Aboody Rosie , Velez‐Ginorio Joey , Santos Laurie R. , Jara‐Ettinger Julian 
Published: March 2023

AbstractFrom early in childhood, humans exhibit sophisticated intuitions about how to share knowledge efficiently in simple controlled studies. Yet, untrained adults often fail to teach effectively in real‐world situations. Here, we explored what causes adults to struggle in informal pedagogical exchanges. In Experiment 1, we first showed evidence of this effect, finding that adult participants failed to communicate their knowledge to naïve learners in a simple teaching task, despite reporting high confidence that they taught effectively. Using a computational model of rational teaching, we found that adults assigned to our teaching condition provided highly informative examples but failed to teach effectively because their examples were tailored to learners who were only considering a small set of possible explanations. In Experiment 2, we then found experimental evidence for this possibility, showing that knowledgeable participants systematically misunderstand the beliefs of naïve participants. Specifically, knowledgeable participants assumed naïve agents would primarily consider hypotheses close to the correct one. Finally, in Experiment 3, we aligned learners’ beliefs to knowledgeable agents’ expectations and showed learners the same examples selected by participants assigned to teach in Experiment 1. We found that these same examples were significantly more informative once learners’ hypothesis spaces were constrained to match teachers’ expectations. Our findings show that, in informal settings, adult pedagogical failures result from an inaccurate representation of what naïve learners believe is plausible and not an inability to select informative data in a rational way.
Preclinical assessment of drug–drug interaction of fb‐PMT, a novel anti‐cancer thyrointegrin αvβ3 antagonist
Authors: Fujioka Kazutoshi , Fekry Mostafa I. , Rumsey Jeanne M. , Steiner Toni , Thompson David , Mousa Shaker A. 
Published: March 2023

AbstractThe objective of the current study was to identify potential drug–drug interactions (DDIs) with the drug candidate fb‐PMT, a novel anticancer thyrointegrin αvß3 antagonist. This was accomplished by using several in vitro assays to study interactions of fb‐PMT with both cytochrome P450 (CYP) enzymes and drug transporters, two common mechanisms leading to adverse drug effects. In vitro experiments showed that fb‐PMT exhibited weak reversible inhibition of CYP2C19 and CYP3A4. In addition, fb‐PMT did not show time‐dependent inhibition with any of the seven CYP isoforms tested, including 1A2, 2B6, 2C8, 2C9, 2C19, 2D6, and 3A4. Human liver microsomal incubations demonstrated that fb‐PMT is stable. Potential transporter‐mediated DDIs with fb‐PMT were assessed with two ATP binding cassette (ABC) family transporters (P‐glycoprotein and breast cancer resistance protein) using Caco2 cells and seven solute carrier family (SLC) transporters (organic cation transporter OCT2, organic anion transporters OAT1 and OAT3, organic anion transporter peptides OATP1B1 and OATP1B3, and the multidrug and toxic extrusion proteins MATE1 and MATE2‐K using transfected HEK293 cells). Fb‐PMT was not a substrate for any of the nine transporters tested in this study, nor did it inhibit the activity of seven of the transporters tested. However, fb‐PMT inhibited the uptake of rosuvastatin by both OATP1B1 and OATP1B3 with half‐maximal inhibitory concentrations greater than 3 and less than 10 μM. In summary, data suggest that the systemic administration of fb‐PMT is unlikely to lead to DDIs through CYP enzymes or ABC and SLC transporters in humans.
Ethical requirements in job advertisements: A deep learning approach
Authors: Liu Rong , Li Ming , Sin Sherry , Tan Michael 
Published: March 2023

AbstractThis study examines ethical requirements in job advertisements as a proxy to understand how ethical qualities are required in the job market. We apply deep learning and natural language processing to analyze the ethical requirements in 196,272 job postings from 13,703 companies across a variety of industries and professions. This large sample allows us to generate a holistic review of ethical requirements in job postings by industry and profession. Specifically, our results show that less than half of the job postings in our sample include requirements for ethics, despite increased attention to ethical conduct. The IT industry had the fewest job postings with ethical requirements compared to other industries. Of the topics within ethical requirements coded in this study, obligations to professional standards occurred most frequently whereas information confidentiality and privacy are less prevalent. Our results have important implications for the ethical practices of businesses and academic ethical education.