bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of spatial lag on modeling geomatic covariates using analysis of variance
Authors: Contreras Aquiles Enrique Darghan , Lozada Darlley Stiven Taborda , Sotomayor Nair Jose Gonzalez , Moreno Carlos Armando Rivera , Noreña Jesus Efren Ospina 
Published: August 2023

Abstract

In recent years, statistical methods involving spatial considerations have been developed, for example, those incorporating data with some type of georeferencing. The descriptive part of geographic information systems currently provides many visualization and analytic tools; however, the latter is still quite limited. In this sense, research of a spatial nature is seen as combining non-spatial statistical methods for inferential treatment that can certainly invalidate the excellent capture work with advanced tools such as those observed every day in the geomatic context. This prompted the current document, drawing attention to how geomatic information analyzed with statistical methods that imply independence in modeled observations can be invalid. The Moran index is compared with a proposal for a spatial lag coefficient in the context of experimental design so that users of variance analysis do not apply this well-known procedure in a ritualistic way, perhaps revising some assumptions and perhaps ignoring more important ones. The distortion of the p value generated from the analysis of variance is clear in the presence of spatial dependence. In this case it is associated with the lag or spatial overlap. The methodology is simple to adopt in other experimental designs with the simple consideration of the design matrix and its reparameterization and the choice of the appropriate weight matrix. This will allow users to reconsider the traditional method of analysis and incorporate some methodology to support spatial dependency structures.
Genome-wide Identification and Bioinformatics Analysis of the UGT Gene Family in Vitis vinifera L
Authors: wenhang Hou , chongyao Chen , wei Liu , na He , min Tan , jinyv He , zhenghai Liu , zhigang Dong 
Published: August 2023

Abstract
UGT (uridine diphosphate glycos-yltransferase) is involved in the process of glycosylation modification and plays an important role in plant growth and development, secondary metabolism and stress response. The aim of this study was to investigate the role of UGT in the biosynthesis of grape secondary metabolites based on the genome-wide identification of grape UGT gene family. Gene family identification, bioinformatics analysis, gene mapping, phylogenetic tree analysis, conservative motif prediction, gene structure and cis-element analysis were performed by using the software. Combined with transcriptome data and KEGG enrichment analysis, genes related to secondary metabolic processes were screened. We identified 181 UGT genes in the grape genome and divided them into 18 subfamilies. Comprehensive analysis showed that fragment duplication events had significant effects on the evolution of VvUGT gene family, and the motif distribution of proteins in the same subfamily was similar Developmental, hormonal, and stress-related cis-elements are enriched in the promoter region. We identified 14 genes in the VvUGT family that may be involved in anthocyanin synthesis. These results provide a theoretical basis for further study on the mechanism of VvUGT gene family regulating the synthesis of plant secondary metabolites.
Determinants of the incidence of heart failure in diabetics in Goma, North Kivu, the Democratic Republic of the Congo
Authors: Mukoso Ferdinand Ng’ekieb , Wembomyama Stannislas Okitotsho , Nkodila Aliocha Natuhoyila , Mbala Cédric Kalala , Kamuanga Zéphirin Tudienzela , Kapongo Remy Yobo , Lubanga Yves Nsimba , Kianu Bernard Phanzu , Situakibanza Hippolyte Nani tuma , Longo-Mbenza Benjamin , Pithuwa Jason Nirwooth , Tsongo Zacharie Kibendelwa 
Published: August 2023

Abstract
Background
Individuals with diabetes mellitus are at increased risk of developing heart failure due to the contributing influence of diabetes mellitus risk factors. But data on African literature are rare. The objective of this study is to evaluate the determinants of heart failure in patients with diabetes mellitus followed in Goma.
Methods
Asymptomatic diabetics in the city of Goma were cross-sectionally recruited at the Center of the Association of Diabetics in Congo (ADIC) in Goma, DRC during the period from February 5 to 19, 2023. The incidence of heart failure was determined using pulse pressure (PP). A PP value ≥ 65 mmHg was considered as an incidence of heart failure. The association between the incidence of HF and the independent variables was evaluated by two models using the logistic regression test at the threshold of p < 0.05.
Results
The incidence frequency of heart failure was 29.9%. In multivariate analysis, adjusted for all these variables in multivariate in the two whose menopause and sex were collinear, the following variables emerged as determinants of incidence of HF in diabetics: hypertension (aOR: 5.93 IC95%: 2.42–14.51), DS type 2 (aOR: 3.60 95% CI: 1.63–4.25), menopause (aOR: 5.48 95% CI: 3.03-9, 72) and eGFR < 60 ml/min/1.73m² (aOR: 348 95% CI: 1.94–5.30), female sex (aOR: 2.80 95% CI: 1.06–3.80) and pathological fundus (aOR: 2.04, 95% CI: 1.77–5.35).
Conclusion
The frequency of HF is high in asymptomatic diabetics in Goma. It is determined by gender, menopause, dS type 2, pathological fundus and altered eGFR.
Biomechanical effect of Chinese manual therapy for cervical spondylotic radiculopathy after percutaneous endoscopic cervical foraminotomy and diskectomy: A finite element study
Authors: Wang Huihao , Shen Zhibi , Fan Xin , Li Xiaofei , Wang Kuan , Zhan Hongsheng , Yu Zhongxiang , Zheng Yuxin 
Published: August 2023

Abstract
With the recurrence of symptoms and emergence of accompanying disorders for intractable cervical spondylotic radiculopathy (CSR) after cervical spine surgery, Chinese manual therapy (CMT) may be an alternative. Therefore, this study aimed to assess and compare the biomechanical impact of CMT on the cervical spine before and after percutaneous endoscopic cervical foraminotomy and diskectomy (PECFD) with resection at three different extents by the finite element analysis. A three-dimensional finite element digital model of C0-C7, representing a normal and intact cervical spine, was created and validated. Subsequently, the finite element model of PECFD was derived by modifying the validated model. Four different models were subjected to load conditions simulating CMT. Various biomechanical parameters, including range of motion (ROM), intervertebral disc pressure (IDP), and stress on facet ligaments, were calculated for both the operated segment and the adjacent segment under different motion conditions. The maximum displacement (MD) of the cervical spine induced by load 1 was higher than that of the other load. The rotation angle (RA) of M3 was lower in right bending and right rotation and higher in extension. The maximum stress of the annulus fibrosus matrix of the intervertebral disc was calculated during the whole movement of the cervical spine. The more tissue that was removed from the intervertebral disc, the higher was the maximum stress of the annulus fibrosus matrix under the two CMTs. For most cervical segments, the intact model and three PECFD models had little effect on the intervertebral disc pressure (IDP) during physiological activity and the two CMTs. However, the IDP in the operated C5-6 segment of the PECFD models was mostly higher than that of the intact segment. The stress of the right FLs of C5-6 in the PECFD models exceeded that of the intact model during left and right lateral bending; significantly, the stress on M3 was found to be 1.5 times higher than that observed in the intact model. Conversely, in comparison to the intact model, the stress experienced by the left facet ligaments (FLs) of the C5-6 segment in M3 was reduced by 60% and 65% respectively. Although the removal of the annulus fibrosus had minimal impact on cervical spinal stability in the model, it should be noted that the nucleus pulposus was not considered. Considering this limitation, follow-up CMT could potentially offer benefits. With the increase in resection, CMT is more likely to cause reprotrusion and instability with regard to the short-term curative effect.
Cathode regeneration processes enabled transition from spent batteries to lithium-ion alternatives
Authors: Chen Zhongwei , Yang Tingzhou , Luo Dan , Zhang Xinyu , Gao Shihui , Gao Rui , Ma Qianyi , Park Hey Woong , Or Tyler , Zhang Yongguang 
Published: August 2023

Abstract

The development of electric vehicles is accelerating the world's transition to sustainable energy, but the millions of end-of-life electric vehicles generated over the next decade pose serious waste management challenges, especially the recycling of spent batteries. Here we propose two cathode regeneration processes to enable scalable and affordable recycling of spent lithium-ion batteries (LIBs) into brand-new LIBs and their alternatives, such as sodium-ion batteries (SIBs). The regenerated layered oxide materials deliver a reversible area capacity of up to 2.73 mAh cm− 2 with excellent structural stability for LIBs, while obtained cyanide complex manifests an 83.7% retention over 2000 cycles for SIBs and robust cycling stability for pouch cells. By contrast, the manufacturing costs for LIBs and SIBs using our regenerated materials have dropped to an all-time low of $47.16 and $37.49 per kWh, with conspicuous reductions in energy consumption, water consumption, and harmful gas emissions. Our sustainable battery recycling designs pave the way for the transition to more sustainable energy storage technologies, enabling post-LIBs with regenerated materials.
Hemostatic markers and polymorphisms in three families with Legg-Calvé-Perthes disease
Authors: Olivas Armando Rodríguez , Hernadez-Zamora Edgar , Casas-Avila Leonora , Lezama-Palacios Ruth , Reyes-Maldonado Elba 
Published: August 2023

Abstract
Legg-Calvé-Perthes Disease (LCPD) is a rare disease caused by avascular necrosis of the femoral head. Although its etiology is still not fully understood, evidence suggests heritable prothrombotic and inflammatory environmental factors may be implicated in its onset and progress. Our objective is to describe the genetic, biochemical markers, and environmental factors that may be associated with the etiology of LCPD. This study was conducted in three families and included seven related patients, with diagnosis of LCPD. We evaluated the following gene alterations: MTHFR, CBS, PT, FVL, FVIII, FIX, PAI-1, eNOS, IL-23R, and TNF-α, by real time PCR. Additionally, we assessed thrombophilia-associated biochemical markers. In addition, environmental factors were detected. Our results show different hemostatic alterations in every individual analyzed, presenting out-of-range values in one or more parameters. Concentrations in hemoglobin, fibrinogen, homocysteine, FVIII, and FIX activity percentage showed statistically significant differences when comparing with healthy controls. All patients present at least one mutated allele for the MTFHR (rs1801133) and IL-23R (rs1569922) polymorphisms, as well as isolated cases with other genetic variants. Our results show environmental elements from every family and hemostatic and inflammatory disorders may be involved in suffering and developing LCPD. Also, heritable factors could contribute to the onset of the disease.
No side effects on retina or vitreous microenvironment by YAG laser vitreolysis in vivo
Authors: Lin Tiezhu , Zhang Mingqin , Wu Bing , An Yuanlong , Pazo Emmanuel Eric , Li Rong , Shen Lijun 
Published: August 2023

Abstract
Background: To explore the safety of yttrium-aluminum-garnet (YAG) laser vitreolysis based on the histological examination of the retina and the alteration of vitreous cytokines in vivo.
Methods: Nine male New Zealand rabbits underwent YAG laser vitreolysis of 10 mJ x 500 pulses in the left eyes, while the right eyes were used as controls. Intraocular pressure, color fundus photography, and ultrasound B scan were measured before, as well as 1 day, 4 weeks, and 12 weeks after YAG laser vitreolysis. Three rabbits were euthanized 1 day, 4 weeks, and 12 weeks after treatment, respectively. Terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) staining and hematoxylin-eosin (H&E) staining were used to look for pathological changes in the retina. An enzyme-linked immunosorbent assay (ELISA) was utilized to detect the expression of vascular endothelial growth factor (VEGF) and some inflammatory cytokines, including interferon inducible protein 10 (IP-10), monocyte chemoattractant protein 1 (MCP-1) and interlenkin 6 (IL-6) in the vitreous humor. The ascorbic acid (AsA) and total reactive antioxidant potential (TRAP) in the vitreous humor were also measured.
Results: Following YAG laser vitreolysis, the levels of VEGF, IP-10, MCP-1, IL6, AsA, and TRAP in the vitreous humor did not change substantially (P > 0.05). There were no detectable pathological changes in the retinal tissues, and no apoptotic signal was found.
Conclusions: YAG laser vitreolysis has no noticeable effects on retinal tissue or the microenvironment of the vitreous, so it is a safe procedure.
Psychopathological Characteristics in Patients with Digestive Problems: A Comparative Analysis with a Healthy Control Group
Authors: Javanmard Gholam Hossein , Javanmard Shahin 
Published: August 2023

Abstract
Introduction:
This study aimed to compare the psychopathological characteristics of patients with digestive (gastrointestinal) problems with those of a healthy control group.
Methods
A total of 70 patients with gastrointestinal issues were referred to the gastroenterology department, and 70 healthy individuals were included in the study. Both groups completed the 90-question mental health questionnaire (SCL-90-R).
Results
The results demonstrated significantly higher average scores in the patients' group across various scales, including depression, aggression, somatization, sensitivity in social relationships, obsession, anxiety, phobia, and psychotic symptoms. Overall, the group with digestive problems exhibited more symptoms associated with these eight mental disorders than the healthy control group. However, there were no notable differences between the two groups, except for the presence of paranoid ideations as a distinguishing characteristic.
Conclusions
This research unequivocally establishes a strong association between gastrointestinal issues and mental well-being, highlighting the influence of digestive system functioning on mental health. These findings contribute to a deeper understanding of the psychopathological aspects related to gastrointestinal conditions.
Forecasting Stock Prices Changes Using Long-Short Term Memory Neural Network with Symbolic Genetic Algorithm
Authors: Li Qi , Kamaruddin Norshaliza , Al-Jaifi Hamdan Amer Ali 
Published: August 2023

Abstract
This paper presents an enhanced Long-Short Term Memory Neural Network (LSTM) framework that combines Symbolic Genetic Algorithm (SGA) to predict cross-sectional price returns for 4500 listed stock in China from 2014 to 2022. Using the S&P Alpha Pool Dataset for China, the framework incorporates data augmentation and feature selection techniques. The study demonstrates significant improvements in Rank Information coefficient (Rank IC) and IC information ratio (ICIR) by 1128% and 5360% respectively when applied to fundamental indicators. For technical indicators, the hybrid model achieves a 206% increase in Rank IC and an impressive surge of 2752% in ICIR. Furthermore, a simple rule-based strategy based on the proposed hybrid SGA-LSTM model outperforms major Chinese stock indexes, generating average annualized excess returns of 31.00%, 24.48%, and 17.38% compared to the CSI 300 index, CSI 500 index, and the average portfolio, respectively. These findings highlight the effectiveness of LSTM with SGA in optimizing the accuracy of cross-sectional stock return predictions and provide valuable insights for fund managers, traders, and financial analysts.
Transition readiness among Finnish adolescents with juvenile idiopathic arthritis
Authors: Mikola Katriina , Rebane Katariina , Kautiainen Hannu , Aalto Kristiina 
Published: August 2023

Abstract
Background
With chronic diseases, the responsibility for care transfers to adult clinics at some point. Juvenile idiopathic arthritis (JIA) is the most common persistent rheumatic condition in children. A successful transition requires sufficient self-management skills to manage one´s chronic condition and all the tasks involved. In this study, we evaluated transition readiness in Finnish patients with JIA. We aimed to find practical tools to support a successful transition and to study the possible consequences of an unsuccessful transition.
Methods
The usefulness of a specific questionnaire, which was administered to 83 JIA patients, was evaluated in this study. We also gathered information from their first adult clinic visit to assess the success of their transition and its relation to disease activity.
Results
In 55 (71%) patients, the transition was estimated to be successful. We were able to determine a cut-off score in the questionnaire for a successful transition: the best estimate for a successful transition is when the score is 24 or more. At the first adult clinic visit, an unsuccessful transition was evident in its effect on disease outcome. If the transition was defined as successful, the DAS28 was better.
Conclusion
We found the questionnaire to be a useful tool for evaluating transition readiness. Determination of a successful transition helped us identify those adolescents who needed more profound support to improve their self-management skills and thus enhance their transition process. An unsuccessful transition was shown to negatively impact on disease outcomes.
Antimicrobial prophylaxis for vesicoureteral reflux: which subgroups of children benefit the most?
Authors: Zhao Beibo , Ivanova Anastasia , Shaikh Nader 
Published: August 2023

Abstract
Background: While the Randomized Intervention for children with Vesicoureteral Reflux (RIVUR) trial found that long-term antimicrobial prophylaxis reduced the risk of urinary tract infection (UTI) recurrences by 50%, 10 children had to be treated with long-term antimicrobial prophylaxis for one to benefit (i.e., observed number needed to treat (NNT) of 10). Accordingly, we re-analyzed RIVUR data to systematically identify subgroups of children with vesicoureteral reflux (VUR) with a smaller NNT.
Methods: Using patient-level data from the RIVUR trial, we applied penalized regression methods including the baseline age, VUR, and bowel-bladder dysfunction (BBD) as covariates to identify subgroups that consider the trade-off between absolute risk difference and size.
Results: We identified three relevant subgroups of children that appear to benefit from long-term antimicrobial prophylaxis, all with NNTs smaller than the NNT of 10. Children with grade IV VUR and BBD, 1% of the RIVUR sample, had a NNT of 2; children with BBD, 12% of the RIVUR sample, had a NNT of 4; children with BBD (and any grade VUR) or with grade IV VUR (regardless of BBD status), which was the combination of the first two subgroups and included 19% of children in the RIVUR sample, had a NNT of 4.
Conclusions: Use of long-term antimicrobial prophylaxis appears to be particularly relevant for children with BBD (and any grade of VUR) or those with grade IV VUR (regardless of BBD status) who were at high risk of UTI recurrences.
A Cross-sectional Study of the Sexual History and Contraceptive Use of Female Hairdressers in Ghana
Authors: Owusu Lydia Boampong , Zakaria Abdul-Fatawu Suglo , Dwumfour Catherine Kroamah , Emikpe Abigael Omowumi , Akosua Abrafi Shirley , Boatemaa Osei Justina , Dorothy Nartey Akumaa Lameley , Dzomeku Veronica 
Published: August 2023

Abstract
The social environment of the hairdressing salon provides the opportunity to discuss sexual exploits among peers and this may easily influence decisions concerning sexual behaviour. Hairdressing salon workers are often women in their reproductive years and may be at risk of unintended pregnancy and self-induced abortions. Therefore, the effective use of contraceptives is imperative among these age groups. The study assessed the sexual history and contraceptive use among female hairdressers in two (2) selected communities in Ghana. Methods: A descriptive cross-sectional design with a quantitative method was employed in two communities within Kumasi city. Convenience sampling was used to select 109 hairdressers after using Yamane’s formula to calculate sample sizes. Data were collected using a questionnaire and analysed using SPSS. Results: The majority of the respondents (73.4%) had their first sexual activity within 15–19 years. A total of 64.2% had ever conceived, with 72.9% of the pregnancies being unintended. All the respondents had knowledge of contraceptives. More than 80% of respondents reported that they had ever used a contraceptive method, with the calendar method being the most previously and currently used method. Age and educational level had a significant effect on contraceptive knowledge (p < 0.001), while marital status, educational level, occupation, age at first sex and ever having an unintended pregnancy influenced contraceptive use (p < 0.05), and contraceptive knowledge influenced its usage (p = 0.003). Conclusion: The study found the calendar method to be the most commonly used contraceptive, which has a high failure rate compared to artificial contraceptive methods, which may have explained the high rate of pregnancy among participants. It is therefore crucial that sexually active women are provided accurate information on family planning methods. Implications: Knowing the sexual behaviour of hairdressers, their knowledge and their use of contraceptives will help nurses and midwives tailor education to their needs. This study calls for intense education on contraceptives targeted at artisans. Again, it will help influence policy change on artisan training and other reproductive health programmes targeted at hairdressers.
How post-infection status could lead to the increasing risks of chronic fatigue syndrome and the potential mechanisms: A 17-year population-based Cohort study
Authors: Chang Hsun , Kuo Chien-Feng , Yu Teng-Shun , Ke Liang-Yin , Hung Chung-Lieh , Tsai Shin-Yi 
Published: August 2023

Abstract
Background: Serological studies have suggested that viruses and atypical pathogens are associated with CFS, but no study has focused on typical and common pathogens. This study aims to assess the association of infections with a variety of common pathogens with the risk of CFS and provide evidence for the hypothesis that infection triggers CFS.
Methods: The nested case-control study identified 2,000,000 adult patients from a nationwide population-based health insurance claims database from January 1, 2000, to December 31, 2017. Each case with a diagnosis of infection by pathogens was matched with one control using a propensity score. Patients with more than one potential pathogen, younger than 20 years old, or with a history of CFS or infection with certain pathogens before the index date were excluded. Univariate and multivariate Cox proportional hazard models were applied to estimate the HR, aHR, and corresponding 95% CI. The multivariate analysis had adjustments for age, sex, comorbidities, and medication confounders.
Results: A total of 395,811 cases with 1:1 matched controls were included (58.2% female; mean age [standard deviation], 44.15 [17.02]). Among these, the aHR of the pathogen cohort was 1.5 (95% CI, 1.47 to 1.54). Pathogens were positively correlated with CFS, including influenza, candida and others.
Conclusion: The findings of this study demonstrate the association between CFS and infection with common pathogens, including bacteria, virus and fungi.