bluuebunny/crossref_metadata_2025_split huggingface dataset:
MEK1/2 inhibition decreases pro-inflammatory responses in macrophages from people with cystic fibrosis and mitigates severity of illness in experimental murine methicillin-resistantStaphylococcus aureusinfection
Authors: De Mithu , Hisert Katherine B. , Liles W. Conrad , Manicone Anne M. , Hemann Emily A. , Long Matthew E. 
Published: January 2023

ABSTRACTChronic pulmonary bacterial infections and associated inflammation remain a cause of morbidity and mortality in people with cystic fibrosis (PwCF) despite new modulator therapies. Therapies targeting host factors that dampen detrimental inflammation without suppressing immune responses critical for controlling infections remain limited, while the acquisition of antibiotic resistance bacterial infections is an increasing global problem, and a significant challenge in CF. Pharmacological compounds targeting the mammalian MAPK proteins MEK1 and MEK2, referred to as MEK1/2 inhibitor compounds, have potential combined anti-microbial and anti-inflammatory effects. Here we examined the immunomodulatory properties of MEK1/2 inhibitor compounds PD0325901, trametinib, and CI-1040 on CF innate immune cells. Human CF macrophage and neutrophil phagocytic functions were assessed by quantifying phagocytosis of serum opsonized pHrodo redE. coli,Staphylococcus aureus, and zymosan bioparticles. MEK1/2 inhibitor compounds reduced CF macrophage pro-inflammatory cytokine production without impairing CF macrophage or neutrophil phagocytic abilities. Wild-type C57BL6/J andCftrtm1kth(F508del homozygous) mice were used to evaluate the in vivo therapeutic potential of PD0325901 compared to vehicle treatment in an intranasal methicillin-resistantStaphylococcus aureus(MRSA) infection with the community-acquired MRSA strain USA300. In both wild-type and CF mice, PD0325901 reduced infection related weight loss compared to vehicle treatment groups but did not impair clearance of bacteria in lung, liver, or spleen 1 day after infection. In summary, this study provides the first data evaluating the therapeutic potential of MEK1/2 inhibitor to modulate CF immune cells, and demonstrates that MEK1/2 inhibitors dampen pro-inflammatory responses without impairing host defense mechanisms mediating pathogen clearance.
Multiscale imaging and quantitative analysis of plasma membrane protein-cortical actin interplay
Authors: Dasgupta Aparajita , Ngo Huong-Tra , Tschoerner Deryl , Touret Nicolas , Rocha-Azevedo Bruno da , Jaqaman Khuloud 
Published: January 2023

AbstractThe spatiotemporal organization of cell surface receptors is important for cell signaling. Cortical actin (CA), the subset of the actin cytoskeleton subjacent to the plasma membrane (PM), plays a large role in cell surface receptor organization. This was however shown largely through actin perturbation experiments, which raise concerns of nonspecific effects and preclude quantification of actin architecture and dynamics under unperturbed conditions. These limitations make it challenging to predict how changes in CA properties can affect receptor organization. To derive direct relationships between the architecture and dynamics of CA and the spatiotemporal organization of PM proteins, including cell surface receptors, we developed a multiscale imaging and computational analysis framework based on the integration of single-molecule imaging (SMI) of PM proteins and fluorescent speckle microscopy (FSM) of CA (combined: SMI-FSM) in the same live cell. SMI-FSM revealed differential relationships between PM proteins and CA based on the PM proteins’ actin binding ability, diffusion type and local CA density. It also highlighted the complexity of cell wide actin perturbation, where we found that global changes in actin properties caused by perturbation were not necessarily reflected in the CA properties near PM proteins, and the changes in PM protein properties upon perturbation varied based on the local CA environment. Given the widespread use of SMI as a method to study the spatiotemporal organization of PM proteins and the versatility of SMI-FSM, we expect it to be widely applicable to enable future investigation of the influence of CA architecture and dynamics on different PM proteins, especially in the context of actin-dependent cellular processes, such as cell migration.SignificancePlasma membrane protein organization, an important factor for shaping cellular behaviors, is influenced by cortical actin, the subset of the actin cytoskeleton near the plasma membrane. Yet it is challenging to directly and quantitatively probe this influence. Here, we developed an imaging and analysis approach that combines single-molecule imaging, fluorescent speckle microscopy and computational statistical analysis to characterize and correlate the spatiotemporal organization of plasma membrane proteins and cortical actin. Our approach revealed different relationships between different proteins and cortical actin, and highlighted the complexity of interpreting cell wide actin perturbation experiments. We expect this approach to be widely used to study the influence of cortical actin on different plasma membrane components, especially in actin-dependent processes.
Lack of Fzd6 in Ciliated Cells Suppresses Ferroptotic Pulmonary Alveolar Cell Death Induced by LPS and Coronavirus
Authors: Yuan Qianying , Luan Yi , Rajendran Barani Kumar , Compton Susan , Tang Wenwen , Wu Dianqing 
Published: January 2023

ABSTRACTPulmonary inflammation compromises lung barrier function and underlies many lung diseases including acute lung injury and acute respiratory distress syndrome (ARDS). However, mechanisms by which lung cells respond to the damage caused by the inflammatory insults are not completely understood. Here we show that Fzd6-deficiency in Foxj1+ciliated cells reduces pulmonary permeability, lipid peroxidation, and alveolar cell death accompanied with an increase in alveolar number in lungs insulted by LPS or a mouse coronavirus. Single-cell RNA sequencing of lung cells indicates that the lack of Fzd6, which is expressed in Foxj1+cells, increases expression of the aldo-keto reductase Akr1b8 in Foxj1+cells. Intratracheal administration of the Akr1b8 protein phenocopies Fzd6-deficient lung phenotypes. In addition, ferroptosis inhibitors also phenocopy Fzd6-deficient lung phenotypes and exert no further effects in Fzd6-deficient lungs. These results reveal an important mechanism for protection of alveolar cells from ferroptotic death during pulmonary inflammation by Foxj1+ciliated cells via paracrine action of Akr1b8.
MAPK/MAK/MRK overlapping kinase (MOK) controls microglial inflammatory/type-I IFN responses via Brd4 and is involved in ALS
Authors: Pérez-Cabello Jesús A. , Silvera-Carrasco Lucía , Franco Jaime M. , Capilla-González Vivian , Armaos Alexandros , Gómez-Lima María , García-García Raquel , Yap Xin Wen , Leal-Lasarte M. Magdalena , Lall Deepti , Baloh Robert H. , Martínez Salvador , Miyata Yoshihiko , Tartaglia Gian G. , Sawarkar Ritwick , García-Dominguez Mario , Pozo David , Roodveldt Cintia 
Published: January 2023

AbstractAmyotrophic lateral sclerosis (ALS) is a fatal and incurable neurodegenerative disease affecting motor neurons and characterized by microglia-mediated neurotoxic inflammation whose underlying mechanisms remain incompletely understood. In this work we reveal that MAPK/MAK/MRK overlapping kinase (MOK), with unknown physiological substrate, displays an immune function by controlling inflammatory and type-I IFN responses in microglia which are detrimental to primary motor neurons. Moreover, we uncover the epigenetic reader bromodomain-containing protein 4 (Brd4) as the first molecule regulated by MOK, by promoting Ser492-phospho-Brd4 levels. We further demonstrate that MOK regulates Brd4 functions by supporting its binding to cytokine gene promoters, therefore enabling innate immune responses. Remarkably, we show that MOK levels are increased in ALS spinal cord, particularly in microglial cells, and that administration of a chemical MOK-inhibitor to ALS model mice is able to modulate Ser492-phospho-Brd4 levels, suppress microglial activation and modify disease course, indicating a pathophysiological role of MOK kinase in ALS and neuroinflammation.
miR-203 drives breast cancer cell differentiation
Authors: Martínez-Illescas Nuria G. , Leal Silvia , González Patricia , Graña-Castro Osvaldo , Muñoz-Oliveira Juan José , Cortés-Peña Alfonso , Quintela-Fandino Miguel , Ciruelos Eva , Sanz Consuelo , Aragón Sofía , Sotolongo Leisy , Jiménez Sara , Caleiras Eduardo J. , Mulero Francisca , Sánchez Cristina , Malumbres Marcos , Salazar-Roa María 
Published: January 2023

AbstractA hallmark of many malignant tumors is dedifferentiated (immature) cells bearing slight or no resemblance to the normal cells from which the cancer originated. Tumor dedifferentiated cells exhibit a higher capacity to survive to chemo and radiotherapies and have the ability to incite tumor relapse. Inducing cancer cell differentiation would abolish their self-renewal and invasive capacity and could be combined with the current standard of care, especially in poorly differentiated and aggressive tumors (with worst prognosis). However, differentiation therapy is still in its early stages and the intrinsic complexity of solid tumor heterogeneity demands innovative approaches in order to be efficiently translated into the clinic. We demonstrate here that microRNA 203, a potent driver of differentiation in pluripotent stem cells (ESCs and iPSCs), promotes the differentiation of mammary gland tumor cells. Combining mousein vivoapproaches and both mouse and human-derived tridimensional organoid cultures, we report here that miR-203 influences the self-renewal capacity, plasticity and differentiation potential of breast cancer cells, and prevents tumor cell growth in vivo. Our work sheds light on differentiation-based antitumor therapies and offers miR-203 as a promising tool for directly confronting the tumor-maintaining and regeneration capability of cancer cells.
An integrated FTA and games: exploring a strategic framework for developing the future
Authors: Sartori Simone , Marinho Sidnei Vieira 
Published: January 2023

Purpose
The main objective of this research was to combine the integration between two fields of knowledge – future-oriented technology analysis (FTA) and games. This study aims to capture the stakeholders’ actions and decision-making in a procedural, interactive and collaborative way to find a vision of the future.

Design/methodology/approach
The framework was designed from a literature review on the related research topics, exploring elements and methods, also how we brought the two fields together. The framework was structured in four steps: exploring – deciding – matching – evaluating. For each phase, deep reflections were described to understand the current situation, identify essential future issues and provide recommendations for action.

Findings
One attractive aspect of the FTA-games is the characteristics of each field but combined made it possible to evaluate future developments and trends. The elements present in games can boost FTA activities through interaction, engagement, experiences, collaboration and motivation, among other elements. Systematically, we seek to ensure traceability by identifying challenges, solutions, execution and results achieved and using tools and elements that make prospecting practical.

Originality/value
This article systematizes the connection between two fields in the form of a framework. At each stage of the framework, participants and strategists are challenged to seek solutions to future challenges, allowing these participants to engage in a common cause and make actions tangible. Game elements can be shaped to explore new avenues in FTA activities, as they are used in games in specific subject domains. These fields tend to be fragmented and are not integrated.
Islamic approach to corporate social responsibility: an international model for Islamic banks
Authors: Hanic Aida , Smolo Edib 
Published: January 2023

PurposeThis study aims to present a corporate social responsibility (CSR) model that would apply to Islamic banks, considering the international aspect of social responsibility because CSR is not applicable in the same way in all types of societies.Design/methodology/approachBased on the extensive review of the existing literature, the authors aim to present an Islamic CSR model applicable to Islamic banks. This study is based on the international approach to CSR developed by Masoud (2017). Each responsibility has an equal share but with specific changes regarding the order of priorities between them and the type of responsibility.FindingsThe findings show that the existing literature provides several Islamic CSR models. Most of these models are general and offer guidelines to Islamic financial institutions, but no model applies exclusively to Islamic banks. Using these models for Islamic banks is challenging because of their specific business activities, especially in non-Muslim countries. This study proposes a model that could act as the main guideline for Islamic banks with enough flexibility to meet different market and stakeholders’ requirements.Practical implicationsThe model was not tested on a sample, and not all Islamic principles were considered. However, it is applicable for Islamic banks, especially considering internationalization in their businesses and the further development of Islamic banking. At the same time, this model puts ethical norms in the spotlight. This is particularly emphasized in the case of non-Muslim countries or in societies where a particular law does not regulate Islamic bank activities.Originality/valueAlthough there is a growing literature on this topic, existing studies primarily discuss the Islamic approach to CSR from the overall perspective, not in a specific industry. While some authors developed their own Islamic CSR models relying on the primaryShariahsources, others base their proposals on other classical CSR ideas. To the best of the authors’ knowledge, this is the first study based on the CSR model developed by Masoud (2017), considering the relationship between economics and religion and the implications of the Islamic moral economy.
Gaslighting and its application to interpersonal violence
Authors: Dickson Prashansa , Ireland Jane L. , Birch Philip 
Published: January 2023

Purpose
The study aims to examine the nature of gaslighting and how it relates to interpersonal aggression.

Design/methodology/approach
It does so first through application of a Rapid Evidence Assessment (REA) to understand how gaslighting is understood academically. This RAE captured 50 articles, with 12 retained for thematic review. Results were then used to develop a gaslighting behaviour measure, which was then applied in an online study of adults (n = 386; 77.2% women).

Findings
Five themes were identified from the REA: components of gaslighting; gaslighting as a tool for abuse; perpetrators as damaged manipulators; experiences and characteristics of victims; and institutional and racial gaslighting. In the ensuing study, results demonstrated that emotional abuse was broadly related both to the perpetration and experiencing of gaslighting, indicating that it may represent an extension of emotional abuse. The relationship to trait aggression was limited and primarily isolated to victims presenting with higher levels of trait aggression capturing more emotional components (e.g. anger/hostility).

Research limitations/implications
The importance of context in understanding the relationship between gaslighting, emotional abuse and aggression was indicated, with some complexity found. Suggestions for future research are made.

Practical implications
Accounting for context in understanding gaslighting is key. Developing and validating measures for gaslighting would assist with the evaluation of this behaviour. When working with those who have a history of emotional abuse, considering gaslighting as a further element is potentially important. It should not be assumed that gaslighting has an association with non-emotional aggression; the type of relationship where it is occurring is important.

Originality/value
This study is the first to consider the development of a gaslighting measure, which is informed by a methodological review of the literature.
Collective action in social entrepreneurial ventures: the role of shared meaning
Authors: Ntamu Diana Nandagire , Balunywa Waswa , Nsereko Isa , Kwemarira Godwin 
Published: January 2023

Purpose
Social entrepreneurs engage in collective action to adapt and solve social problems in complex environments. Through collective action, they mobilise and access resources to create positive social change in local communities. While previous studies explain the role of social identity in promoting cooperation, this paper aims to examine shared meaning as a predictor of collective action in social entrepreneurial ventures (SEVs). This study was conducted among founders of SEVs focusing on their engagement in collective action.

Design/methodology/approach
The study adopted a cross-sectional survey to achieve its objectives. The population comprised 558 SEVs registered with the Kampala Capital City Authority in Uganda. A sample size of 226 social ventures was determined using Krecjie and Morgan and participants were selected using the simple random sampling technique. The questionnaires were distributed by two research assistants, and 210 completed questionnaires were returned. Structural equation modelling was used to analyse survey data and test the study hypotheses.

Findings
The study findings show that shared meaning in the form of teamwork and group efficacy predict collective action in SEVs.

Research limitations/implications
The results have implications for social entrepreneurship researchers, practitioners and policymakers. Firstly, creating social ties by belonging to different groups in the community creates common understanding among social entrepreneurs and other actors fostering cooperation to solve problems in the local community. Secondly, understanding each other’s perspective well enough facilitates a shared view of social problems for combined action.

Practical implications
SEVs should provide relevant information using the right channels in local communities to promote collaboration. Failure to use the right communication channels may prevent collective action. Managers in social ventures should allow for open information sharing between themselves and the partners that they work with to address social problems. This enables them to share both the good and bad feedback. It also enables the growth of teams and improves how they work. The teams should be developed with specific responsibilities so that everyone is clear on what they should do while addressing social problems.

Originality/value
The researchers argue that shared meaning develops when social entrepreneurs interact with the local community and other stakeholders prompting joint action to address social problems. This study extends knowledge on collective action using the activity domain theory.
Contribution of Islamic banks and macroeconomic variables to economic growth in developing countries: vector error correction model approach (VECM)
Authors: Kismawadi Early Ridho 
Published: January 2023

Purpose
The purpose of this study is to examine the effect of Islamic banks (IBs) and macroeconomic variables on economic growth in Saudi Arabia, the United Arab Emirates, Kuwait, Malaysia, Qatar, Bahrain and Bangladesh.

Design/methodology/approach
Based on these criteria, 672 observations from 24 IBs in Saudi Arabia, the United Arab Emirates, Kuwait, Malaysia, Qatar, Bahrain and Bangladesh were chosen for further investigation. Time series analysis is a well-known method for determining if model variables are stationary and how long-term relationships function through cointegration analysis. This study uses impulse response function (IRF) and variance decomposition (VD) methodologies to demonstrate how each macroeconomic variable shock influences the short-term dynamic path of all system variables.

Findings
Islamic banking promotes economic growth, especially in Saudi Arabia, the UAE, Kuwait, Malaysia, Qatar, Bahrain and Bangladesh. The findings of the Islamic banking VDC test have a direct and long-term effect on economic growth.

Research limitations/implications
The literature on this topic can be improved in a number of ways, including by adopting a more robust method to analyze over a longer time frame. By researching specific financing in various areas of the economy, one can gain a deeper understanding of Islamic financing. This will enable the identification of sectors that contribute to economic expansion. Future research should examine combining nations with pure Islam and dual-banking systems to acquire sufficient data.

Practical implications
This paper has practice and research implications. It recommends adopting the nation’s successful experiment with the Islamic banking system as a model for attaining economic growth through Islamic financing. To replicate this successful experiment, government-based decision-makers and monetary policy experts must collaborate to make Islamic money flows simple and rapid through financial channels that enhance economic growth.

Originality/value
The study of the contribution of Islamic banking to economic growth in developing nations, particularly those with the highest total assets (TAs) and total deposits (TDs) in the world, remains of modest value. To the best of the authors’ knowledge, this is the first study to empirically assess the impact of IBs in developing nations, particularly those with the highest TAs and TDs in the world, on economic growth as measured by gross domestic product (GDP).
Árbol Que Nace Torcido, Jamás Su Tronco Endereza/tree that is born crooked, its trunk never straightens: unlearning colonization at a Hispanic Serving Institution
Authors: Scholz Teresa Maria Linda , Flores Carmona Judith 
Published: January 2023

PurposeReplicating colonization at Hispanic Serving Institutions (HSIs) must be addressed from the root, structurally. At New Mexico State University (NMSU) the authors are aimed to commit to going beyond counting and enrolling, to center servingness.Design/methodology/approachHSIs will continue to struggle in fulfilling their mission, especially given the fast-growing Latina/e/o/x populations in the United States (US). A major challenge all HSIs face is the contrasting demographics between the student population, the faculty and staff and the administration – with HSI administrations consistently being predominantly White.FindingsHence, in this piece the authors shed light on the important work the authors have done these last two years through collaborative efforts to transform the institution and center servingness. Judith as the Interim Director of Chicano Programs, and Linda as the inaugural Vice President for equity, inclusion and diversity.Originality/valueHerein, the authors now share about the genre of testimonio as a decolonial methodology and about the experiences in our work as we attempt to decolonize the praxis at an HSI.