bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multifunctional Hydroxyapatite Nanobelt Haystacks Integrated Neural Stem Cell Spheroid for Rapid Spinal Cord Injury Repair
Authors: Hao Min , Chen Lu , He Jianlong , Zhao Xiaolei , Xia He , Chen Xin , Yu Liyang , Qiu Jichuan , Feng Shiqing , Sang Yuanhua , Zhou Hengxing , Liu Hong 
Published: March 2023

AbstractDue to the unwarranted lifespan and differentiation, applying neural stem cells (NSCs) in spinal cord injury (SCI) remains challenging. In this study, 3D bioactive hydroxyapatite (HAp) nanobelt haystack‐mouse NSC (mNSC) hybrid spheroids are customized in which the specific nanobelt haystack framework provided the structural function of hypoxia alleviation in the spherical core and biological process of neural differentiation promotion. Commodified with superparamagnetic ferroferric oxide (Fe3O4) nanoparticles and a polydopamine (PDA) coating, the HAp nanobelts are endowed with magnetic field‐driven properties and enhanced cell‐nanobelt adhesion. The engineered bioresponsive 3D nanobelt haystack‐mNSC hybrid spheroids effectively repair SCI in vivo, showing new potential for stem cell therapy by incorporating nanomaterials in 3D culture based on cell‐material interactions.
Linker Defects in Metal–Organic Frameworks for the Construction of Interfacial Dual Metal Sites with High Oxygen Evolution Activity
Authors: Ni Chunyan , Zheng Han , Liu Weiwei , Wu Liang , Li Rui , Zhou Kun , Zhang Wang 
Published: March 2023

AbstractDesigning efficient electrocatalysts based on metal–organic framework (MOF) nanosheet arrays (MOFNAs) with controlled active heterointerface for the oxygen evolution reaction (OER) is greatly desired yet challenging. Herein, a facile strategy for the synthesis of MOF‐based nanosheet arrays (γ‐FeOOH/Ni‐MOFNA) is developed with abundant heterointerfaces between Ni‐MOF and γ‐FeOOH nanosheets by introducing linker defects to the former. The experimental and theoretical results show the key role of linker defects in inducing the growth of secondary γ‐FeOOH nanosheets onto the surface of Ni‐MOFNAs, which further leads to the formation of interfacial Ni/Fe dual sites with high oxygen evolution activity. Notably, the resulting γ‐FeOOH/Ni‐MOFNA exhibits excellent OER performance with low overpotentials of 193 and 222 mV at 10 and 100 mA cm−2, respectively. Furthermore, the study of the structure–performance relationship of MOF‐based heterostructures reveals that Ni sites at the interface of the γ‐FeOOH/Ni‐MOFNA have higher activity than those at the interface of NiFe layered double hydroxide and Ni‐MOFNA. This study provides a new prospect on heterostructured electrocatalysts with highly active sites for enhanced OER.
Polytonic Drug Release via Multi‐Hierarchical Microstructures Enabled by Nano‐Metamaterials
Authors: Lou Qi , Feng Feng , Hui Junfeng , Zhang Peisen , Qin Shijie , Ouyang Xiaoping , Wu Dazhuan , Wang Xiuyu 
Published: March 2023

Abstract″Nano‐metamaterials″, rationally designed novel class metamaterials with multilevel microarchitectures and both characteristic sizes and whole sizes at the nanoscale, are introduced into the area of drug delivery system (DDS), and the relationship between release profile and treatment efficacy at the single‐cell level is revealed for the first time. Fe3+‐core‐shell‐corona nano‐metamaterials (Fe3+‐CSCs) are synthesized using a dual‐kinetic control strategy. The hierarchical structure of Fe3+‐CSCs, with a homogeneous interior core, an onion‐like shell, and a hierarchically porous corona. A novel polytonic drug release profile occurred, which consists of three sequential stages: burst release, metronomic release, and sustained release. The Fe3+‐CSCs results in overwhelming accumulation of lipid reactive oxygen species (ROS), cytoplasm ROS, and mitochondrial ROS in tumor cells and induces unregulated cell death. This cell death modality causes cell membranes to form blebs, seriously corrupting cell membranes to significantly overcome the drug‐resistance issues. It is first demonstrated that nano‐metamaterials of well‐defined microstructures can modulate drug release profile at the single cell level, which in turn alters the downstream biochemical reactions and subsequent cell death modalities. This concept has significant implications in the drug delivery area and can serve to assist in designing potential intelligent nanostructures for novel molecular‐based diagnostics and therapeutics.
Alloying of Cu with Ru Enabling the Relay Catalysis for Reduction of Nitrate to Ammonia
Authors: Gao Wensheng , Xie Kefeng , Xie Jin , Wang Xiaomei , Zhang Hong , Chen Shengqi , Wang Hao , Li Zelong , Li Can 
Published: March 2023

AbstractInvolving eight electron transfer process and multiple intermediates of nitrate (NO3−) reduction reaction leads to a sluggish kinetic and low Faradaic efficiency, therefore, it is essential to get an insight into the reaction mechanism to develop highly efficient electrocatalyst. Herein, a series of reduced‐graphene‐oxide‐supported RuCu alloy catalysts (RuxCux/rGO) are fabricated and used for the direct reduction of NO3− to NH3. It is found that the Ru1Cu10/rGO shows the ammonia formation rate of 0.38 mmol cm−2 h−1 (loading 1 mg cm−2) and the ammonia Faradaic efficiency of 98% under an ultralow potential of −0.05 V versus Reversible Hydrogen Electode (RHE), which is comparable to Ru catalyst. The highly efficient activity of Ru1Cu10/rGO can be attributed to the synergetic effect between Ru and Cu sites via a relay catalysis, in which the Cu shows the exclusively efficient activity for the reduction of NO3− to NO2− and Ru exhibits the superior activity for NO2− to NH3. In addition, the doping of Ru into Cu tunes the d‐band center of alloy and effectively modulates the adsorption energy of the NO3− and NO2−, which promotes the direct reduction of NO3− to NH3. This synergetic electrocatalysis strategy opens a new avenue for developing highly efficient multifunctional catalysts.
Lipid Deposition Profiles Influence Foreign Body Responses
Authors: Schreib Christian C. , Jarvis Maria I. , Terlier Tanguy , Goell Jacob , Mukherjee Sudip , Doerfert Michael D. , Wilson Taylor Anne , Beauregard Michael , Martins Kevin N. , Lee Jared , Sanchez Solis Leonardo D. , Vazquez Esperanza , Oberli Matthias A. , Hanak Brian W. , Diehl Michael , Hilton Isaac , Veiseh Omid 
Published: March 2023

AbstractFibrosis remains a significant cause of failure in implanted biomedical devices and early absorption of proteins on implant surfaces has been shown to be a key instigating factor. However, lipids can also regulate immune activity and their presence may also contribute to biomaterial‐induced foreign body responses (FBR) and fibrosis. Here it is demonstrated that the surface presentation of lipids on implant affects FBR by influencing reactions of immune cells to materials as well as their resultant inflammatory/suppressive polarization. Time‐of‐flight secondary ion mass spectroscopy (ToF‐SIMS) is employed to characterize lipid deposition on implants that are surface‐modified chemically with immunomodulatory small molecules. Multiple immunosuppressive phospholipids (phosphatidylcholine, phosphatidylinositol, phosphatidylethanolamine, and sphingomyelin) are all found to deposit preferentially on implants with anti‐FBR surface modifications in mice. Significantly, a set of 11 fatty acids is enriched on unmodified implanted devices that failed in both mice and humans, highlighting relevance across species. Phospholipid deposition is also found to upregulate the transcription of anti‐inflammatory genes in murine macrophages, while fatty acid deposition stimulated the expression of pro‐inflammatory genes. These results provide further insights into how to improve the design of biomaterials and medical devices to mitigate biomaterial material‐induced FBR and fibrosis.
Realization and Current‐Driven Dynamics of Fractional Hopfions and Their Ensembles in a Helimagnet FeGe
Authors: Yu Xiuzhen , Liu Yizhou , Iakoubovskii Konstantin V. , Nakajima Kiyomi , Kanazawa Naoya , Nagaosa Naoto , Tokura Yoshinori 
Published: March 2023

Abstract3D topological spin textures—hopfions—are predicted in helimagnetic systems but are not experimentally confirmed thus far. By utilizing an external magnetic field and electric current in the present study, 3D topological spin textures are realized, including fractional hopfions with nonzero topological index, in a skyrmion‐hosting helimagnet FeGe. Microsecond current pulses are employed to control the dynamics of the expansion and contraction of a bundle composed of a skyrmion and a fractional hopfion, as well as its current‐driven Hall motion. This research approach has demonstrated the novel electromagnetic properties of fractional hopfions and their ensembles in helimagnetic systems.
Photoallosteric Polymersomes toward On‐Demand Drug Delivery and Multimodal Cancer Immunotherapy
Authors: Zheng Yi , Liu Yang , Wu Zhongchao , Peng Chuan , Wang Zuojie , Yan Jingyue , Yan Yue , Li Zifen , Liu Congcong , Xue Jianxin , Tan Hong , Fu Qiang , Ding Mingming 
Published: March 2023

AbstractAllosteric transitions can modulate the self‐assembly and biological function of proteins. It remains, however, tremendously challenging to design synthetic allosteric polymeric assemblies with spatiotemporally switchable hierarchical structures and functionalities. Here, a photoallosteric polymersome is constructed that undergoes a rapid conformational transition from β‐sheet to α‐helix upon exposure to near‐infrared light irradiation. In addition to improving nanoparticle cell penetration and lysosome escape, photoinduced allosteric behavior reconstructs the vesicular membrane structure, which stimulates the release of hydrophilic cytolytic peptide melittin and hydrophobic kinase inhibitor sorafenib. Combining on‐demand delivery of multiple therapeutics with phototherapy results in apoptosis and immunogenic death of tumor cells, remold the immune microenvironment and achieve an excellent synergistic anticancer efficacy in vivo without tumor recurrence and metastasis. Such a light‐modulated allosteric transition in non‐photosensitive polymers provides new insight into the development of smart nanomaterials for biosensing and drug delivery applications.
Multi‐Stimuli‐Responsive Amphiphilic Pyridinium Salt and Its Application in the Visualization of Level 3 Details in Latent Fingerprints
Authors: Chen Yi , Li Aisen , Li Xiaoning , Tu Liangjing , Xie Yujun , Xu Shuping , Li Zhen 
Published: March 2023

AbstractOrganic luminescent materials that can simultaneously achieve multimode mechanochromism and its water‐vapor‐induced recovery are desirable for practical applications but rarely reported. Herein, an amphiphilic compound, 4‐(9H‐carbazol‐9‐yl)‐1‐(2‐hydroxyethyl)pyridin‐1‐ium bromide (CPAB), is designed by integrating a lipophilic aromatic unit and hydrophilic end in the molecular architecture. Self‐recovered mechanochromism from brown to cyan is observed upon mechanical grinding in air. Comprehensive research by X‐ray diffraction, infrared spectroscopy, and single‐crystal analysis reveals that the photoluminescence switch originates from the variation in intermolecular hydrogen bonds and molecular packing mode. The amphiphilic nature of CPAB allows water molecules to enter the crystalline lattice, forming two polymorphs of the crystalline phase, namely CPAB‐D and CPAB‐W. The hydrosoluble CPAB exhibits excellent capability in probing the level 3 details of fingerprints because its lipophilic part can target the fatty acid residues of fingerprints, leading to strong aggregation‐induced fluorescence. The research may inspire the design of latent fingerprint developers and application in forensics/anti‐counterfeiting.
Blood‐Glucose‐Powered Metabolic Fuel Cell for Self‐Sufficient Bioelectronics
Authors: Maity Debasis , Guha Ray Preetam , Buchmann Peter , Mansouri Maysam , Fussenegger Martin 
Published: March 2023

AbstractCurrently available bioelectronic devices consume too much power to be continuously operated on rechargeable batteries, and are often powered wirelessly, with attendant issues regarding reliability, convenience, and mobility. Thus, the availability of a robust, self‐sufficient, implantable electrical power generator that works under physiological conditions would be transformative for many applications, from driving bioelectronic implants and prostheses to programing cellular behavior and patients’ metabolism. Here, capitalizing on a new copper‐containing, conductively tuned 3D carbon nanotube composite, an implantable blood‐glucose‐powered metabolic fuel cell is designed that continuously monitors blood‐glucose levels, converts excess glucose into electrical power during hyperglycemia, and produces sufficient energy (0.7 mW cm−2, 0.9 V, 50 mm glucose) to drive opto‐ and electro‐genetic regulation of vesicular insulin release from engineered beta cells. It is shown that this integration of blood‐glucose monitoring with elimination of excessive blood glucose by combined electro‐metabolic conversion and insulin‐release‐mediated cellular consumption enables the metabolic fuel cell to restore blood‐glucose homeostasis in an automatic, self‐sufficient, and closed‐loop manner in an experimental model of type‐1 diabetes.
Interfacial Degradation and Pattern Evolution of Exfoliated Graphene by Cyclic Mechanical Loading
Authors: Guo Yongjie , Yu Senjiang , Lu Chenxi , Hu Liang , Su Weitao , Li Lingwei 
Published: March 2023

AbstractThe interfacial interactions between 2D materials and polymer substrates receive increasing interest due to the surge of flexible electronics, multifunctional coatings, and nanocomposites. Although the strain effect on electrical, optical, and mechanical properties of 2D materials is extensively investigated, understanding the interfacial mechanics of 2D material‐polymer systems by dynamic loading is still a challenge. Here, the interfacial degradation and pattern evolution of mechanically exfoliated single‐ and few‐layer graphene on polydimethylsiloxane (PDMS) substrates by cyclic mechanical loading, are reported. It is found that the tensile strain leads to interfacial slippage between graphene and PDMS, whereas the compressive strain can be transferred to graphene with a transfer efficiency above 80%. Through cyclic loading, the graphene surface is seriously deformed by formation of multiple instability patterns including wrinkles and cracks. The morphological characteristic and evolution mechanism of the wrinkles and cracks are analyzed and discussed in detail. The interfacial adhesion energy is evaluated by wrinkle profiles and it decreases from ≈23 to ≈2 mJ m−2 as the cycle number increases. This work can promote better understanding of the interfacial effect of 2D materials on polymer substrates and controllable fabrication of various wrinkled or crumpled surfaces of 2D functional materials by cyclic mechanical loading.
Quantum Energy Storage in 2D Heterointerfaces
Authors: Sharma Monika , Ajayan Pulickel M. , Deb Pritam 
Published: March 2023

AbstractTo address the global energy and environmental crisis, advanced energy storage systems with their superior electrochemical performances have been growing exponentially. The electrochemical properties of the selected electrode materials have a direct impact on the performance of these energy storage technologies. 2D structures are considered promising materials for energy storage systems because of their unique and outstanding electrochemical characteristics. Therefore, hybridization of 2D nanosheets with other low‐dimensional materials can improve storage capacity by modulating and exploiting the synergy between the same. This comprehensive review highlights energy storage devices, their mechanisms, and key problems, with a focus on electrodes made of new generation 2D hybrids. Following that, the strategies that enable face‐to‐point, face‐to‐line, and face‐to‐face heterointerfaces are discussed in details. In addition, a design approach is provided for synergistically coupling 2D with other quantum materials for designing efficient and long‐lasting storage systems. It is anticipated that this review article will serve as helpful motivation for developing excellent energy storage devices with improved electrochemical capability.
Bio‐Inspired Compact, High‐Resolution Snapshot Hyperspectral Imaging System with 3D Printed Glass Lightguide Array
Authors: Hong Zhihan , Sun Yuanyuan , Ye Piaoran , Loy Douglas A. , Liang Rongguang 
Published: March 2023

AbstractTo address the major challenges to obtain high spatial resolution in snapshot hyperspectral imaging, 3D printed glass lightguide array is developed to sample the intermediate image in high spatial resolution and redistribute the pixels in the output end to achieve high spectral resolution. Curved 3D printed lightguide array can significantly simplify the snapshot hyperspectral imaging system, achieve better imaging performance, and reduce the system complexity and cost. Two‐photon polymerization process to print glass lightguide array is developed, and the system performance with biological samples is demonstrated. This new snapshot technology will catalyze new hyperspectral imaging system development and open doors for new applications from UV to infrared.
A Bio‐Liposome Activating Natural Killer Cell by Illuminating Tumor Homogenization Antigen Properties
Authors: Yang Xue , Bian Jiayi , Wang Zheng , He Mengning , Yang Ying , Li Quanhao , Luo Xinping , Zhou Zhanwei , Li Jing , Ju Shenghong , Sun Minjie 
Published: March 2023

AbstractNatural killer (NK) cell therapies, primarily based on chimeric antigen receptor NK cells (CAR‐NK), have been developed and applied clinically for therapeutic treatment of patients with mid‐to‐late‐stage tumors. However, NK cell therapy has limited efficacy due to insufficient antigen expression on the tumor cell surface. Here, a universal “illuminate tumor homogenization antigen properties” (ITHAP) strategy to achieve stable and controlled antigen expression on the surface of tumor cells using nanomedicine, thus significantly enhancing the immune recognizability of tumor cells, is described. The ITHAP strategy is used to generate bio‐liposomes (Pt@PL‐IgG) composed of intermingled platelet membranes and liposomes with NK‐activatable target antigen (IgG antibodies) and cisplatin pre‐drug. It is demonstrated that Pt@PL‐IgG successfully targets tumor cells using the autonomous drive of platelet membranes and achieves IgG implantation on tumor cells by utilizing membrane fusion properties. Moreover, it is shown that the Pt‐DNA complex combined with NK cell‐induced pyroptosis causes substantial interferon (IFN) secretion, thus providing a synthase‐stimulator of interferon genes (STING)‐IFN‐mediated positive immune microenvironment to further potentiate NK therapy. These results show that anchoring cancer cells with NK‐activatable target antigens is a promising translational strategy for addressing therapeutic challenges in tumor heterogeneity.
Robust Spontaneous Raman Flow Cytometry for Single‐Cell Metabolic Phenome Profiling via pDEP‐DLD‐RFC
Authors: Wang Xixian , Ren Lihui , Diao Zhidian , He Yuehui , Zhang Jiaping , Liu Min , Li Yuandong , Sun Lijun , Chen Rongze , Ji Yuetong , Xu Jian , Ma Bo 
Published: March 2023

AbstractA full‐spectrum spontaneous single‐cell Raman spectrum (fs‐SCRS) captures the metabolic phenome for a given cellular state of the cell in a label‐free, landscape‐like manner. Herein a positive dielectrophoresis induced deterministic lateral displacement‐based Raman flow cytometry (pDEP‐DLD‐RFC) is established. This robust flow cytometry platform utilizes a periodical positive dielectrophoresis induced deterministic lateral displacement (pDEP‐DLD) force that is exerted to focus and trap fast‐moving single cells in a wide channel, which enables efficient fs‐SCRS acquisition and extended stable running time. It automatically produces deeply sampled, heterogeneity‐resolved, and highly reproducible ramanomes for isogenic cell populations of yeast, microalgae, bacteria, and human cancers, which support biosynthetic process dissection, antimicrobial susceptibility profiling, and cell‐type classification. Moreover, when coupled with intra‐ramanome correlation analysis, it reveals state‐ and cell‐type‐specific metabolic heterogeneity and metabolite‐conversion networks. The throughput of ≈30–2700 events min−1 for profiling both nonresonance and resonance marker bands in a fs‐SCRS, plus the >5 h stable running time, represent the highest performance among reported spontaneous Raman flow cytometry (RFC) systems. Therefore, pDEP‐DLD‐RFC is a valuable new tool for label‐free, noninvasive, and high‐throughput profiling of single‐cell metabolic phenomes.
Conformational Regulation of Dielectric Poly(Vinylidene Fluoride)‐Based Solid‐State Electrolytes for Efficient Lithium Salt Dissociation and Lithium‐Ion Transportation
Authors: Huang Yan‐Fei , Zeng Jian‐Ping , Li Shuang‐Feng , Dai Chen , Liu Jun‐Feng , Liu Chen , He Yan‐Bing 
Published: March 2023

AbstractRestricted by the poor ability of polymers to dissociate lithium salts and transport ions, solid‐state polymer electrolytes (SPEs) show extremely low ionic conductivities (≈10−7–10−5 S cm−1) and transference number of lithium ions (tLi+ ≈0.2–0.4) at 25 °C. Here, a novel polymer matrix of SPEs that simultaneously promotes lithium salt dissociation and ion transportation based on a high dielectric poly(vinylidene fluoride‐trifluoroethylene‐chlorotrifluoroethylene) (TerP) and an all‐trans conformational poly(vinylidene fluoride‐trifluoroethylene) (CoP), is developed. The high dielectric constant increases the polarity of CH2CF2 polar groups; then, brings a strong electronegative end that dissociates Li+ from lithium salts. The all‐trans conformation assures all fluorine atoms locate on one side of the chain, constructing ion hopping highways. As a result, the TerP/CoP (TC) SPE exhibits a high ionic conductivity (2.37 × 10−4 S cm−1) and a quite large tLi+ of 0.61 at 25 °C. The Li/TC SPE/Li symmetric cells cycle stably for more than half a year (>4500 h) and the LiNi0.8Co0.1Mn0.1O2/TC SPE/Li cell cycles steadily for 1000 and 600 cycles at 1 C and 2 C at 25 °C, respectively. This work paves a new way to prepare high‐performance SPEs by simultaneously modulating dielectric constants and conformation of polymers.