bluuebunny/crossref_metadata_2025_split huggingface dataset:
circRNA-SFMBT2 orchestrates ERα activation to drive tamoxifen resistance in breast cancer cells
Authors: Li Zheng , Li Yaming , Han Dianwen , Wang Xiaolong , Li Chen , Chen Tong , Li Wenhao , Liang Yiran , Luo Dan , Chen Bing , Wang Lijuan , Zhao Wenjing , Yang Qifeng 
Published: July 2023

AbstractDysregulated ERα signaling is responsible for endocrine resistance and eventual relapse in patients with estrogen receptor-positive (ER+) breast cancer. Thus, identifying novel ERα regulators is necessary to fully understand the mechanisms of endocrine resistance. Here, we identified circRNA-SFMBT2 to be highly expressed in ER+ breast cancer cells in comparison to ER− cells and found that high circRNA-SFMBT2 levels were related to larger tumor size and poor prognosis in patients with ER+ breast cancer. In vitro and in vivo experiments confirmed that the circRNA-SFMBT2 level was positively correlated with the ERα protein level, implying a regulatory role for circRNA-SFMBT2 in ERα signaling. Moreover, we found that circRNA-SFMBT2 biogenesis could be facilitated via RNA-binding protein quaking (QKI), and biologically elevated circRNA-SFMBT2 expression promoted cell growth and tamoxifen resistance in ER+ breast cancer. Mechanistically, circRNA-SFMBT2 exhibits a specific tertiary structure that endows it with a high binding affinity for ERα and allows it to interact with the AF2 and DBD domains of ERα, enforcing recruitment of RNF181 to the AF1 domain of ERα. Furthermore, the circRNA-SFMBT2/RNF181 axis differentially regulated K48-linked and K63-linked ubiquitination of ERα to enhance ERα stability, resulting in increased expression of ERα target genes and tumor progression. In summary, circRNA-SFMBT2 is an important regulator of ERα signaling, and antagonizing circRNA-SFMBT2 expression may constitute a potential therapeutic strategy for breast cancer.
Sidewall patterning of organic–inorganic multilayer thin film encapsulation by adhesion lithography
Authors: Lee Seung Woo , Cho Heyjin , Jang Choel-Min , Huh Myung-Soo , Cho Sung Min 
Published: July 2023

AbstractA simple sidewall patterning process for organic–inorganic multilayer thin-film encapsulation (TFE) has been proposed and demonstrated. An Al2O3 thin film grown by atomic layer deposition (ALD) was patterned by adhesion lithography using the difference in interfacial adhesion strength. The difference in interfacial adhesion strength was provided by the vapor-deposited fluoro-octyl-trichloro-silane self-assembled monolayer (SAM) patterns formed by a shadow mask. The sidewall patterning of multilayer TFE was shown possible by repeating the adhesion lithography and the vapor deposition of organic polymer and SAM patterns using shadow masks. The proposed process has the advantage of being able to pattern the blanket ALD-grown Al2O3 thin films by adhesion lithography using a SAM pattern that can be more accurately predefined with a shadow mask.
A repeated cross-sectional analysis on the economic impact of SARS-CoV-2 pandemic at the hospital level in Italy
Authors: Trentini Filippo , Ciani Oriana , Vanni Elena , Ghislandi Simone , Torbica Aleksandra , Azzolini Elena , Melegaro Alessia 
Published: July 2023

AbstractItaly was the first country in Europe to be hit by the Severe Acute Respiratory Syndrome Coronavirus 2. Little research has been conducted to understand the economic impact of providing care for SARS-CoV-2 patients during the pandemic. Our study aims to quantify the incremental healthcare costs for hospitalizations associated to being discharged before or after the first SARS-CoV-2 case was notified in Italy, and to a positive or negative SARS-CoV-2 notified infection. We used data on hospitalizations for 9 different diagnosis related groups at a large Italian Research Hospital with discharge date between 1st January, 2018 and 31st December 2021. The median overall costs for a hospitalization increased from 2410EUR (IQR: 1588–3828) before the start of the pandemic, to 2645EUR (IQR: 1885–4028) and 3834EUR (IQR: 2463–6413) during the pandemic, respectively for patients SARS-CoV-2 negative and positive patients. Interestingly, according to results of a generalized linear model, the highest increases in the average costs sustained for SARS-CoV-2 positive patients with respect to patients discharged before the pandemic was found among those with diagnoses unrelated to COVID-19, i.e. kidney and urinary tract infections with CC (59.71%), intracranial hemorrhage or cerebral infarction (53.33), and pulmonary edema and respiratory failure (47.47%). Our study highlights the economic burden during the COVID-19 pandemic on the hospital system in Italy based on individual patient data. These results contribute to the to the debate around the efficiency of the healthcare services provision during a pandemic.
ZNS- und Nebennierenmetastasen bei Merkelzellkarzinom – ein besonderer Fall
Authors: Hage Sina-Maria , Burbach Guido , Harth Wolfgang 
Published: July 2023

ZusammenfassungDas Merkelzellkarzinom ist ein hochaggressiver, seltener Hauttumor. Bei Erstdiagnose bestehen bereits bei 30% der Patienten loko-regionäre Lymphknotenmetastasen. Fernmetastasen finden sich häufig in entfernten Lymphknotenstationen, der Haut, den abdominellen Organen und den Knochen. Bei Auftreten von Fernmetastasen reduziert sich das 5-Jahres-Überleben auf 18%. Wir berichten über eine Patientin mit Merkelzellkarzinom, die ein Jahr nach Erstdiagnose Fernmetastasen im ZNS und den Nebennieren entwickelte. Beide Lokalisationen sind bisher selten beschrieben. Therapeutisch kamen Radiatio, Radiochirurgie und eine Immuntherapie mit Avelumab zum Einsatz. Während sich hierunter eine komplette Remission der Hirnfiliae zeigte, führte ein rasanter Progress der Nebennierenmetastasen zur Umstellung auf eine palliative platinbasierte Chemotherapie.
Morphological changes analysis using 3D bathymetric surveys in Chilia Branch - Bystroe Channel bifurcation area
Authors: Tudor Georgeta , Deák György , Raischi Marius , Arsene Miruna , Holban Elena , Noor Norazian Mohamed , Amat Roshazita Che 
Published: July 2023

Abstract
The Bystroe Channel project with transboundary environmental impact in the Danube Delta, area of great ecological significance that has already a strong anthropic footprint, requires close monitoring of water quality parameters in order to determine their tendencies and their impact on the ecosystem components. Riverbed bathymetry surveys using multibeam echo-sounders are of high interest due to the data resolution and coverage capabilities that surpass the single-beam methods. Two riverbed elevation datasets, recorded in consecutive years, have been used to carry out morphological comparative analysis for the area where Chilia branch bifurcates in Bystroe Channel and Old Stambul. The analysis has been performed both on the bathymetry grids as a whole and on 3 longitudinal and 9 transversal river sections, the morphological changes values being in majority included in [-0.5 m;+0.5 m], with a minimum of -2.4 m and a maximum of 2.2 m, showing the bifurcation influence on the erosion/deposition processes results.
Risk of contamination of sturgeon species along the Lower Danube with AcIV-E virus from sturgeons raised in aquaculture systems
Authors: Deák Gy , Matache R , Prangate R , Dumitrescu G , Holban E , Lupea L , Norlia Nurliza Rahim , Ibrahim Mohamad 
Published: July 2023

Abstract
It is considered that most infections caused by pathogen agents in fish species raised in the closed medium like fishing farms originate from the natural environment, thus there are few information on virus transmission from species raised in aquaculture programs to the wild ones. This issue is important taking into account that the wild sturgeon populations are critically endangerment, and regarding to the IUCN Red List, two of these are already declared extinct. Within Danube Basin, environmental and anthropic factors series (reproduction habitats lost, hydrotechnical works) have caused the sturgeon distribution area to be restricted mainly in the lower segment of the river. In addition, intensive fishing or the introduction of invasive species have produced negative effects and hence the decrease in the population effectiveness. As result, from six native sturgeon species within Danube Basin, in our days, only four are still found. This review shall include an analysis of the status of knowledge, regarding the possible influence which the transmission of some viruses within sNCLDV from aquaculture species to the wild ones, also it shall propose an assessment of the risk of infection within Danube ichthyofaunal.
Precipitation variations in the central Vietnam to forecast using Holt-Winters Seasonal Additive Forecasting method for 1990 to 2019 trend
Authors: Bhagat Suraj Kumar , Tiyasha  , Ramaswamy Krishnaraj 
Published: July 2023

Abstract
Precipitation played a vital role in the landslide events, water cycle, irrigation management, agriculture yield. The major factor is the extreme weather such as temperature played a vital role in it. This study applied climatological data (30 years of span) of two different geolocation at Vietnam, and applied time series analysis, Holt-Winters Seasonal Additive Forecasting model. The highest Precipitation i.e. 260.83 and 112.96 mm in the month of September and November for Danang and Pleiku, respectively; and total sum of 66550.51 and 34118.38 mm over the period for Danang and Pleiku, respectively. Danang is with higher Precipitation in lesser number of events, and Pleiku is with lower Precipitation though more number of events. Holt-Winters Seasonal Additive Forecasting method revealed the potential forecasting method for the different statistical characteristics data set. Lag plot showed the higher positive as well as the negative lap quartile. Residual error plot present to support the applied model feasibility. Weakness of the study and the future objective of the study drafted.
Removal of Chromium (VI) in Aqueous Solution by Charcoal Adsorbent derived PET Plastic Waste
Authors: Othman Nurul Rusyda , Najib Nor Wahidatul Azura Zainon , Kamarudzaman Ain Nihla 
Published: July 2023

Abstract
This study was conducted to assess the potential of charcoal and activated charcoal derived Polyethylene Terephthalate (PET) as adsorbent through the experiment of chromium hexavalent [Cr (VI)] removal from aqueous solution. The study aims to investigate the optimum adsorption conditions for Cr (VI) removal in aqueous solution under diverse adsorption operating conditions, namely pH, contact time, agitation speed, adsorbent dosage, and initial concentration. The diameter of the charcoal produced was 600 μm. The results showed that 80 % and 90 % of Cr (VI) removal were achieved by using charcoal and activated charcoal, respectively, at pH 5, 150 rpm, 60 min of contact time, 0.5 g of adsorbent dosage, and 0.1 mg/L of Cr (VI) initial concentration. The removal of Cr (VI) was mainly affected by adsorption operating conditions and the physicochemical properties of adsorbents. Langmuir and Freundlich adsorption isotherms were applied to model the adsorption behaviour and determine the adsorption capacity of both PET charcoal adsorbents. The adsorption isotherm plot was well fitted with the Langmuir model.
Lightweight Flame-retardant Material Reinforced with Hevea Brasiliensis Ash Intumescent Agent
Authors: Beh Jing Han , Yew Ming Kun 
Published: July 2023

Abstract
Flame retardant materials play an important role in many building construction components. The ability of building components to resist fire is crucial to the safety and well-being of the occupants. This research examines a lightweight flame-retardant material-Vermiculite (V) reinforced with a renewable Hevea Brasiliensis Biomass Ash Intumescent Agent (HBAIA) in different compositions. Four specimens of vermiculite reinforced with HBAIA (V/HBAIA) with standard size 200 mm x 200 mm x 10 mm (W x Lx H) were fabricated for investigations. All V/HBAIA specimens were assessed in terms of their density, fire-resistant, fire endurance and smoke, char surface morphology, and flexural toughness. Data disclosed V/HBAIA-2 with the composition of 90% vermiculite reinforced with 10% HBAIA obtained the most prominent outcomes in overall. V/HBAIA-2 attained the lightest density of 37.5 kg/m3 and weight of 0.20 kg, with lowest end temperature of 122 °C after exposure to one-hour of 1000 °C fire. This indicated the best fire-resistant performance in V/HBAIA-2. No structural deformation and only mild smoke and odor were observed in V/HBAIA-2 during the fire endurance examination. V/HBAIA-2 was able to resist the maximum loading force of 67.4 N before and 52.5 N after the fire resistant, with the higher flexural toughness value of 1.47 MPa. Scanning electron microscopy revealed a more uniform, denser, closely connected air cavities char cell quality in V/HBAIA-2 explained its superior outcomes in fire-resistant and flexural toughness as compared to the rest of specimens.
Effect of Pyrolysis Temperature of Coconut Fibre Biochar Incorporated in Zn/Al Layered Double Hydroxide for the Removal of Nickel(II)
Authors: Awang Nor Asikin , Salleh Wan Norharyati Wan , Aziz Farhana , Yusof Norhaniza , Ismail Ahmad Fauzi 
Published: July 2023

Abstract
Coconut-fiber biochar (CCFB) pyrolyzed at different pyrolysis temperatures (400°C, 500°C, and 600°C) that immobilized Zn/Al layered double hydroxides (Zn/Al LDH-CCFB) composite adsorbent was prepared via a simple co-precipitation technique. The composite adsorbents were used to reduce the high concentration of Ni(II) metal ions from aqueous solution. The morphological analysis was investigated scanning electron microscopy (SEM). A series of batch adsorption tests was conducted with different parameters, which cover the pH of the solution (3–7), initial concentration of Ni(II) (10–250 mg/L), and contact time of the shaking time (0.16–8 h). Pseudo-second order kinetic model was well fitted for all of the samples, compared to pseudo-first order and intraparticle diffusion kinetic models, with the value of R2 = 0.9993, 0.9719, 0.9924, and 0.9978 for Zn/Al LDH-0, Zn/Al LDH-CCFB400, Zn/Al LDH-CCFB500, and Zn/Al LDH-CCFB600, respectively. Meanwhile, the adsorption process was best described by the Freundlich model with the value of R2 = 0.9311, 0.9987, 0.9843, and 0.9981 for Zn/Al LDH-0, Zn/Al LDH-CCFB400, Zn/Al LDH-CCFB500, and Zn/Al LDH-CCFB600, respectively. From the adsorption performance test, it was found that the adsorption capacity of Zn/Al LDH-CCFB500 that was agitated for 4 h at pH 7 was higher compared with other samples, demonstrating an adsorption capacity of up to 106.95 mg/g. The adsorption capacity of all of the Zn/Al LDH-CCFB had improved, compared to pristine Zn/Al LDH-0. Thus, it is concluded that Zn/Al LDH-CCFB possesses a great potential for the adsorbent in the removal of pollutants, especially the hazardous heavy metal ions.
Organic loads reduction efficiency using natural fiber reinforced polymer encapsulated microalgae macrocapsule for wastewater treatment
Authors: Dollah Zuraisah , Roslan Nurul Ain Sofiya , Alias Salina , Akbar Nor Azliza 
Published: July 2023

Abstract
Organic load such as Chemical Oxygen Demand (COD) increases in the water because of the increase in human growth and industrialisation. The initial goal of the study, to characterise the natural fibre reinforced polymer encapsulated microalgae macrocapsule using Scanning electron microscope (SEM). Second, analyse organic load reduction utilising natural fiber reinforced polymer encapsulated microalgae macrocapsule. The experiment was conducted with five Schott bottles with a 1.7 liter working volume as a photobioreactors. The system was operated with three tubes fabricated with different functions. The first tube was connected to the adjustable air pump oxygen aerator to supply oxygen into the photobioreactor system. The photobioreactor’s second tube is designed to flow out gasses. The last tube is the sampling tube function to withdraw the samples for the efficacy of treatment performance. The photobioreactor will continuously be illuminated with cool-white fluorescent light (Philip TL-D 36W/865, light intensity of 60–70 μmol m-2 s-1). This study employs COD to test microalgae’s organic load reduction. From day 1 to 5, COD value shows a pattern of reduction from 352 mg/L for day 1 and 223 mg/L for day 5, respectively. The analysis reveals that the p-OPEFB (Polymeric Oil Palm Empty Fruit Bunch) macrocapsule has a surface structure with a rough surface before and after treatment. Optical density measures microalgae growth. BBM’s (Bold Basal Medium) increasing absorbance value allows microalgae to develop optimally. Natural fibre reinforced polymer encapsulated microalgae macrocapsule shows potential for wastewater treatment.
Omics-based deep learning approaches for lung cancer decision-making and therapeutics development
Authors: Tran Thi-Oanh , Vo Thanh Hoa , Le Nguyen Quoc Khanh 
Published: July 2023

Abstract
Lung cancer has been the most common and the leading cause of cancer deaths globally. Besides clinicopathological observations and traditional molecular tests, the advent of robust and scalable techniques for nucleic acid analysis has revolutionized biological research and medicinal practice in lung cancer treatment. In response to the demands for minimally invasive procedures and technology development over the past decade, many types of multi-omics data at various genome levels have been generated. As omics data grow, artificial intelligence models, particularly deep learning, are prominent in developing more rapid and effective methods to potentially improve lung cancer patient diagnosis, prognosis and treatment strategy. This decade has seen genome-based deep learning models thriving in various lung cancer tasks, including cancer prediction, subtype classification, prognosis estimation, cancer molecular signatures identification, treatment response prediction and biomarker development. In this study, we summarized available data sources for deep-learning-based lung cancer mining and provided an update on recent deep learning models in lung cancer genomics. Subsequently, we reviewed the current issues and discussed future research directions of deep-learning-based lung cancer genomics research.
Kinesin and myosin motors compete to drive rich multiphase dynamics in programmable cytoskeletal composites
Authors: McGorty Ryan J , Currie Christopher J , Michel Jonathan , Sasanpour Mehrzad , Gunter Christopher , Lindsay K Alice , Rust Michael J , Katira Parag , Das Moumita , Ross Jennifer L , Robertson-Anderson Rae M 
Published: July 2023

Abstract
The cellular cytoskeleton relies on diverse populations of motors, filaments, and binding proteins acting in concert to enable nonequilibrium processes ranging from mitosis to chemotaxis. The cytoskeleton's versatile reconfigurability, programmed by interactions between its constituents, makes it a foundational active matter platform. However, current active matter endeavors are limited largely to single force-generating components acting on a single substrate—far from the composite cytoskeleton in cells. Here, we engineer actin–microtubule (MT) composites, driven by kinesin and myosin motors and tuned by crosslinkers, to ballistically restructure and flow with speeds that span three orders of magnitude depending on the composite formulation and time relative to the onset of motor activity. Differential dynamic microscopy analyses reveal that kinesin and myosin compete to delay the onset of acceleration and suppress discrete restructuring events, while passive crosslinking of either actin or MTs has an opposite effect. Our minimal advection–diffusion model and spatial correlation analyses correlate these dynamics to structure, with motor antagonism suppressing reconfiguration and demixing, while crosslinking enhances clustering. Despite the rich formulation space and emergent formulation-dependent structures, the nonequilibrium dynamics across all composites and timescales can be organized into three classes—slow isotropic reorientation, fast directional flow, and multimode restructuring. Moreover, our mathematical model demonstrates that diverse structural motifs can arise simply from the interplay between motor-driven advection and frictional drag. These general features of our platform facilitate applicability to other active matter systems and shed light on diverse ways that cytoskeletal components can cooperate or compete to enable wide-ranging cellular processes.
Kinematic markers of skill in first-person shooter video games
Authors: Warburton Matthew , Campagnoli Carlo , Mon-Williams Mark , Mushtaq Faisal , Morehead J Ryan 
Published: July 2023

Abstract
Video games present a unique opportunity to study motor skill. First-person shooter (FPS) games have particular utility because they require visually guided hand movements that are similar to widely studied planar reaching tasks. However, there is a need to ensure the tasks are equivalent if FPS games are to yield their potential as a powerful scientific tool for investigating sensorimotor control. Specifically, research is needed to ensure that differences in visual feedback of a movement do not affect motor learning between the two contexts. In traditional tasks, a movement will translate a cursor across a static background, whereas FPS games use movements to pan and tilt the view of the environment. To this end, we designed an online experiment where participants used their mouse or trackpad to shoot targets in both visual contexts. Kinematic analysis showed player movements were nearly identical between contexts, with highly correlated spatial and temporal metrics. This similarity suggests a shared internal model based on comparing predicted and observed displacement vectors rather than primary sensory feedback. A second experiment, modeled on FPS-style aim-trainer games, found movements exhibited classic invariant features described within the sensorimotor literature. We found the spatial metrics tested were significant predictors of overall task performance. More broadly, these results show that FPS games offer a novel, engaging, and compelling environment to study sensorimotor skill, providing the same precise kinematic metrics as traditional planar reaching tasks.