bluuebunny/crossref_metadata_2025_split huggingface dataset:
An inquiry into the drivers of an entrepreneurial economy: A Bayesian clustering approach
Authors: Camacho Maximo , Congregado Emilio , Rodriguez-Santiago Ana 
Published: August 2023

Abstract
Understanding the worldwide drivers of qualified entrepreneurship is a key issue in economic policy design. To help policy decisions exert their intended impact, we aim to cluster a wide range of countries on the basis of their levels and trends in self-employment productivity using a finite mixture model applied to a new large dataset of 121 countries covering the period of 1991–2019. Our results point to three groups of high-, medium-, and low-productive means and tendencies, the geographical distribution of which suggests that they can be reinterpreted using the three stages of economic development, namely, innovation-, efficiency-, and factor-driven economies. Notably, we find that widespread digitalization and low unemployment enhance the probability of transitioning into a highly productive cluster. However, we failed to find that industry weight or employment protection legislation strictness serve as determinants in the transition between groups. Suggestive rationales for these results and implications for the entrepreneurship policy agenda are also provided.
JEL codes: M13; J24; C11; O43
Comparison of the Diagnostic Significance of CSF Metagenomic Next-generation Sequencing Copy Number Variation Analysis and Cytology in Leptomeningeal Malignancy
Authors: Zhang Le , Fang Kechi , Ren Haitao , Fan Siyuan , Wang Jing , Guan Hongzhi 
Published: August 2023

Abstract
Purpose
The early diagnosis of leptomeningeal malignancy remains a formidable challenge in clinical practice. This study aimed to investigate the diagnostic potential of CSF metagenomic next-generation sequencing (mNGS) and chromosome copy number variations (CNVs) analysis in the detection of leptomeningeal malignancy. The diagnostic significance of mNGS-CNVs was compared with that of cytology.
Methods
A total of 51 patients were enrolled. 34 patients were diagnosed with central nervous system (CNS) leptomeningeal malignancy (tumor group), and 17 patients were diagnosed with CNS inflammatory diseases (nontumor group). We explored a well-designed approach utilizing the CSF mNGS-CNVs technique for the early diagnosis of leptomeningeal malignancy. The diagnostic performance of CSF cytology and mNGS-CNVs was evaluated.
Results
CSF cytology displayed a sensitivity of 82.35% (95% CI: 66.83%-92.61%) and a specificity of 94.12% (95% CI: 69.24%-99.69%). In comparison, CSF mNGS-CNVs exhibited a slightly lower sensitivity of 70.59% (95% CI: 52.33%-84.29%), but an impressive specificity of 100% (95% CI: 77.08%-100%). Notably, comparative analysis revealed no significant difference in diagnostic consistency between cytology and mNGS-CNVs. However, mNGS-CNVs exhibited a higher specificity than cytology.
Conclusion
Our study highlighted the advantage of CSF mNGS-CNVs as a diagnostic tool for leptomeningeal malignancy when compared to traditional cytology. This comprehensive approach provides a promising strategy for utilizing CSF mNGS in the detection of CNS tumors.
Characteristics and complete genome analysis of pathogenic Aeromonas veronii from diseased Siniperca chuatsi
Authors: Zhu Xinhai , Qin Lijie , Zhu Yujie , Qian Qieqi , Gao Xiaojian , Jiang Qun , Wang Jun , Liu Guoxing , Zhang Xiaojun 
Published: August 2023

Abstract
As an opportunistic pathogen, Aeromonas veronii can cause hemorrhagic septicemia of various aquatic animals. In our present study, a dominant strain SJ4 isolated from naturally infected mandarin fish (Siniperca chuatsi), was identified as A. veronii according to the morphological, physiological, and biochemical features, as well as molecular identification. Intraperitoneal injection of A. veronii SJ4 into S. chuatsi fingerlings revealed clinical signs similar to the natural infection, and the median lethal dosage (LD50) of the SJ4 to S. chuatsi was 3.8×105 CFU/mL. Histopathological analysis revealed that the isolate SJ4 could cause cell enlargement, obvious hemorrhage and inflammatory responses in S. chuatsi. Detection of virulence genes showed the isolate SJ4 carried act, fim, flgM, ompA, lip, hly, aer, eprCAL and the isolate SJ4 also produce caseinase, dnase, gelatinase, and hemolysin. In addition, the complete genome of A. veronii SJ4 was sequenced, and the size of the genome of A. veronii SJ4 was 4562694 bp, within a G + C content of 58.95%, containing 4079 coding genes. 910 genes encoding for several virulence factors such as type III and VI secretion system, flagella, motility, etc., were determined based on the VFDB database. Besides, 148 antibiotic resistance-related genes in 27 categories related to tetracyclines, fluoroquinolones, aminoglycosides, macrolides, chloramphenicol, and cephalosporins were also annotated. The present results suggested that A. veronii was etiological agent causing the bacterial septicemia of S. chuatsi in this time, as well as provided a valuable base for revealing pathogenesis and resistance mechanism of A. veronii.
SQSTM1/p62 is a prognostic molecular marker and potential therapeutic target for pancreatic neuroendocrine tumours
Authors: Song Yu-Li , Weng Jun-Hua , Zhao Da-Chun , Zhang Jia-Lei , Chen Yuan-Jia , Xu Baohong 
Published: August 2023

Abstract
Background
There have been few studies on the role of autophagy in pancreatic neuroendocrine tumours (PNETs). SQSTM1/p62 (also called Sequestosome 1) is a potential autophagy regulator, and its biological roles and clinical significance in PNETs remain poorly understood.
Purpose
The purpose of this study was to evaluate the clinical significance of SQSTM1/p62 in human PNET specimens and to evaluate its potential value as a therapeutic target by studying its biological function in PNET cell lines.
Methods
SQSTM1/p62 protein expression was assessed in 106 PNET patient specimens by immunohistochemistry, and the relationship between SQSTM1/p62 protein expression and the clinicopathological features of PNETs in patients was analysed. The proliferation, invasion and apoptosis of SQSTM1/p62-knockdown QGP-1 and INS-1 cells were assessed by the MTT assay, a Transwell assay and flow cytometry. Cell autophagy was assessed by western blotting and mCherry-GFP-LC3B.
Results
The protein expression of SQSTM1/p62 in PNET patient specimens was significantly correlated with tumour recurrence (p = 0.005) and worse prognosis (log rank p = 0.020). Downregulation of the SQSTM1/p62 gene inhibited tumour cell proliferation and migration and induced PNET cell death. Downregulation of SQSTM1/p62 activated autophagy in PNET cell lines but blocked autophagic flow. Knockdown of the SQSTM1/p62 gene inhibited mTOR phosphorylation.
Conclusion
The SQSTM1/P62 protein could be an independent prognostic marker for PNET patients. Downregulating SQSTM1/P62 can inhibit PNET progression, inhibit mTOR phosphorylation and block autophagic flow.
To hatch and hatch not: does heterochrony in onset of vestibular mechanosensing explain species differences in escape-hatching success of Agalychnis embryos in snake attacks?
Authors: Güell Brandon André , Warkentin Karen M. 
Published: August 2023

Abstract

Phyllomedusid treefrogs hatch prematurely to escape egg predation, but escape success varies among species. Snake attacks elicited 55% less escape-hatching in spontaneously hatching Agalychnis spurrelli than in less developed A. callidryas. Agalychnis callidryas use their vestibular system and, secondarily, their lateral line to sense physical disturbances that cue hatching. Since A. spurrelli develop faster, we hypothesized that heterochronic shifts in the onset timing of vestibular mechanosensory function, relative to hatching ability, might explain their lower escape response to mechanosensory cues. To test this, we compared onset timings of hypoxia- and mechanosensory-cued hatching (MCH) and vestibular mechanosensory function in developmental series of both species. Across species, most sibships began responding to each cue at the same developmental stage and vestibular function development, measured by the vestibulo-ocular reflex (VOR), was similar. These results demonstrate that low escape-hatching success in A. spurrelli is not caused by a delay in the onset of vestibular mechanosensory function. MCH onset in A. spurrelli was associated with VOR, but with a higher threshold than in A. callidryas. The absence of MCH before strong vestibular function suggests multimodal mechanosensing may not contribute to antipredator responses of A. spurrelli embryos. Our observations of higher escape success of larger clutches in snake attacks and hatching complications in flooded A. spurrelli suggest that differences in clutch and egg capsule structure may contribute directly to species differences in escape-hatching success. Moreover, hatching complications in A. spurrelli may select against false alarms, increasing the stringency of hatching decision rules.
Adaptive Location Method for Film Cooling Holes Based on The Design Intent of The Turbine Blade
Authors: Hou Yaohua , Wang Jing , Mei Jiawei , Zhao Hualong 
Published: August 2023

Abstract
Due to the inevitable deviation of the casting process, the dimensional error of the turbine blade is introduced. As a result, the location datum of the film cooling holes is changed, which has an impact on the machining accuracy. The majority of pertinent studies concentrate on the rigid location approach for the entire blade, which results in a modest relative position error of the blade surface but still fails to give the exact position and axial direction of the film cooling holes of the deformed blade. In this paper, the entire deformation of the blade cross-section curve is divided into a number of deformation combinations of the mean line curve based on the construction method of the blade design intent. The exact location of the film cooling holes in the turbine blade with deviation is therefore efficiently solved by a flexible deformation of the blade that optimizes the position and axial direction of the holes. The verification demonstrates that the novel method can significantly reduce both the contour deviation of the blade surface and the location issue of the film cooling holes. After machining experiments, the maximum position deviation of the holes is reduced by approximately 80% compared to the rigid location method of the entire blade, and the average value and standard deviation are also decreased by about 70%.
Research on the generalization ability of frequency reduction multiplexing for the fall detection algorithm
Authors: Wang Jinghua , Liu Yadong , Qiao Xingshu , Liu Xiaoliang , Zhao Xin 
Published: August 2023

Abstract

The global healthcare coverage systems are actively addressing the issue of patient falls in hospital rooms. To reduce the injury caused by falls and improve the quality of patient care. In this paper, the fall detection system based on the wrist wearable device is studied. The original acceleration data collected by the wearable device is processed by the filtering algorithm to make the corresponding data set. In the face of the sample imbalance problem caused by the small number of fall samples, the time series fragments of fall detection are determined by the event detection mechanism, and the diversity of sample features is increased by reducing the frequency of the original data and re-extracting the features, which improves the performance of the fall detection model. we explored the relationship between sampling frequency and the performance of the fall detection algorithm and found that the model based on low-frequency fall data has a stronger generalization ability. The system realized the classification of 4 fall behaviors such as standing fall and bed fall and 11 daily behaviors such as walking, side-by-side lifting, and leg-clapping, and achieved an average accuracy of 99.02% and a sensitivity of 98.99% in the leave-one-subject cross-validation
Prevalence and trends of brain tumors in a national referral hospital in Nairobi, Kenya
Authors: Gesaka Samwel Rema , Okemwa Parmenas Minda 
Published: August 2023

Abstract

Purpose: To determine the prevalence of brain tumors at a national referral hospital in Nairobi, Kenya.
Methods: This retrospective study retrieved patient-archived records between 2016-2019 at Kenyatta National Hospital. The prevalence of brain tumors was calculated according to the histological types, age, and sex using the Statistical Package for Social Sciences version 24 (IBM Corp., Armonk, NY, USA) and presented in tables and figures.
Results: The average age of all patients diagnosed with brain tumors was 34.43 years. Meningiomas and glioblastomas were the most diagnosed benign and malignant tumors accounting for 36% and 15.5% of cases, respectively. Meningiomas were more common in women, whereas gliomas were more common in men. The combined prevalence rates of brain tumors in children and adolescents (0-19 years) were 28.16 % and 71.84% in adults.
Conclusion: The number of histologically diagnosed brain tumors appeared to increase steadily over the study period. The number of diagnosed cases also increased with increasing patient age, peaking between 35-70 years, and more females compared than males were diagnosed with brain tumors.
Doxycycline reversal of amphetamine-induced mania-like behavior is related to adjusting brain monoamine abnormalities and antioxidant effects in primary hippocampal neurons.
Authors: Chaves-Filho Adriano José Maia , Soares Michele Verde-Ramo , Juca Paloma Marinho , Oliveira Tatiana de Queiroz , Clemente Dino Cesar da Silva , Monteiro Carlos Eduardo da Silva , Silva Francisca Géssica Oliveira , de Aquino Pedro Everson Alexandre , Macedo Danielle S. 
Published: August 2023

Abstract
Purpose: Mania is associated with disturbed dopaminergic transmission in frontotemporal regions. D-amphetamine (AMPH) causes increased extracellular DA levels, considered an acknowledged mania model in rodents. Doxycycline (DOXY) is a second-generation tetracycline with promising neuroprotective properties. Here, we tested the hypothesis that DOXY alone or combined with Lithium (Li) could reverse AMPH-induced mania-like behavioral alterations in mice by the modulation of monoamine levels in brain areas related to mood regulation, as well as cytoprotective and antioxidant effects in hippocampal neurons.
Methods: Male Swiss mice received AMPH or saline intraperitoneal (IP) injections for 14 days. Between days 8-14, mice receive further IP doses of DOXY, Li, or their combination. For in vitro studies, we exposed hippocampal neurons to DOXY in the presence or absence of AMPH. Results: DOXY alone or combined with Li reversed AMPH-induced risk-taking behavior and hyperlocomotion. DOXY also reversed AMPH-induced hippocampal and striatal hyperdopaminergia. In AMPH-exposed hippocampal neurons, DOXY alone and combined with Li presented cytoprotective and antioxidant effects, while DOXY+Li also increased the expression of phospho-Ser133-CREB. Conclusion: our results add novel evidence for DOXY’s ability the reversal of mania-like features while revealing that antidopaminergic activity in some brain areas, such as the hippocampus and striatum, as well as hippocampal cytoprotective effects may account for this drug’s antimanic action. This study provides additional rationale for designing clinical trials investigating its potential as a mood stabilizer agent.
Futuristic Hydroclimatic Projections under CMIP6 GCMs: Implications for Water Resources Management
Authors: Haleem Kashif , Khan Afed Ullah , Khan Fayaz Ahmad , Zada Umar , Khan Jehanzeb , Khan Mehran 
Published: August 2023

AbstractPakistan is primarily dependent on water supplies from the Upper Indus basin for irrigated agriculture. Any changes in available resources due to climate, consequently has the potential to have a significant impact on the environment. Coupled model inter-comparison project phase 6 (CMIP6) based global climate models (GCMs) under shared socioeconomic pathways (SSP245) scenario were assessed to evaluate the study area for climate change effect on river runoff using Soil and water assessment tool (SWAT). Temperature fluctuations have a significant effect on stream flow, since the primary sources of river runoff in the Upper Regions of Indus Basin (URIB) are snow and glacier melting. The temperature (min & max) will likely increase by almost 18% in the future, the projected precipitation pattern will increase by 13-17 %, and the stream flow will increase by 19-30 % in the future due to the warmer temperature. Temperature (min & max), precipitation and stream flow have had different effects in each season, while their variability in the projected annual changes are increasing for mid and late 21stcentury. Hydroelectricity generation, irrigation, flood prevention, and storage reservoir will be required in the strategies and action plans for the effective water resources management.
Causal Association between Glaucoma and Risk of Retinal Vascular Occlusion: A Mendelian Randomization Study
Authors: Wang Zixun , Li Zhiqing 
Published: August 2023

Abstract
Background
Retinal vein occlusion (RVO) is a common retinal vascular disease that leads to visual impairment. In the elderly, risk factors may include glaucoma. Some studies suggest a correlation between glaucoma and RVO, but it remains unknown if the association is causal. The aim of this study was to perform Mendelian randomization(MR) analyses to evaluate the causal contribution of genetically predicted glaucoma to RVO.
Methods
A two-sample MR analysis using the inverse‐variance weighted (IVW), weighted median and MR‐Egger regression methods was performed. We used the publicly available summary statistics data sets of genome‐wide association studies (GWAS) meta‐analyses for glaucoma in individuals of European descent (n = 351696;133492 cases and 90939 controls) as the exposure and a GWAS for RVO Finn Gen biobank study (n = 204613;1595 cases and 203018 controls) as the outcome. We conducted univariable MR analyses to identify the causal effects of RVO. Although inverse variance weighted (IVW) was the primary method used for MR analyses, MR–Egger and weighted-median methods were used as supplements to IVW. We determined the heterogeneity of IVs using Cochrane’s Q test and I2, and used the MR–Egger intercept and MR-PRESSO Global test to detect horizontal pleiotropy.
Results
Genetically predicted glaucoma was found to be causally associated with RVO risk (beta = 0.267,SE = 0.051, odds ratio (OR) = 1.306, 95% confidence interval (CI): 1.181–1.445, P = 3.26×10− 3). This association was supported by sensitivity analyses using the weighted median (beta = 0.211,SE = 0.074,OR = 1.235, 95% CI: 1.064–1.429,P = 0.112), weighted mode (beta = 0.491,SE = 0.132,OR = 1.633, 95% CI: 1.261–2.116, P = 0.05), and MR-Egger (beta = 0.3900,SE = 0.138,OR = 1.476, 95% CI: 1.128–1.933, P = 6.237×10− 2) methods. The MR analyses using the validation dataset obtained consistent results.
Conclusion
The results of MR analysis support that glaucoma may be causally associated with an increased risk of RVO. Furthermore, this is the first study to discuss the causal relationship between glaucoma and RVO at the genetic level. Future studies are required to elucidate the underlying mechanisms.
Effects of machining gap on the surface integrity in CBN spherical magnetic abrasives grinding of ZrO2 ceramic
Authors: Jiang Linzhi , Chang Tieyan , Zhang Guixiang , Chen Yu-Sheng , Liu Xue , Zhang Haozhe 
Published: August 2023

Abstract
Due to the high hardness and brittleness of zirconia ceramic (ZrO2), it is difficult to generate a good surface integrity by traditional grinding. The surface quality of ZrO2 can be greatly improved by magnetic abrasive finishing (MAF) with spherical CBN/Fe-based magnetic abrasive particles (MAPs) prepared by gas atomization. In this study, it was found that the difference of machining gap in MAF would seriously affect the surface integrity of ZrO2. The grinding pressure of CBN MAPs on ZrO2 under different machining gaps was analyzed theoretically. The surface morphology, surface roughness Ra and material removal amount MR, grinding pressure, surface temperature and residual stress, subsurface damage and the morphology of MAPs adsorbed by magnetic pole after grinding were studied under different machining gaps (3 mm to 1 mm). The results show that when the machining gap is large, the grinding pressure is small, the number of MAPs involved in grinding is small, and the surface integrity of ZrO2 do not change significantly. When the machining gap is small and the grinding pressure is too large, a large number of MAPs are extruded from the machining area, the magnetic abrasive brush is changed from flexible to rigid, and the ceramic surface is mainly removed by brittleness. After grinding, many cracks and pits are generated on the ceramic surface, and cracks are also produced on the subsurface, which destroys the surface integrity of the workpiece. Under the appropriate machining gap, it can not only ensure that the grinding pressure is large, but also make the ZrO2 surface mainly plastic removal, and finally obtain the best surface integrity.
The Effects of Dietary patterns on Hedonic Hunger in University Students
Authors: Ulker İzzet , Camli Ayşe , Pourdeh Elham Foroudi , Aksu Zeynep 
Published: August 2023

Abstract
This study was conducted to examine the effect of the Dietary patterns on hedonic hunger. This descriptive, cross-sectional study included 617 university students. The Study data was obtained through a web-based survey form. The survey form includes individuals’ socio-demographic characteristics, anthropometric measurements, Mediterranean Diet Quality Scale (KIDMED), Mediterranean Diet Adherence Scale (MEDAS), and Power of Food Scale (PFS). 503 women and 114 men have participated in the study. The sub-scale score average for food availability in Overweight/obese individuals was found to be significantly higher than that of underweight individuals (p < 0.05). A statistically significant negative correlation was observed at a low level between MEDAS scores and PFS total scores (r=-0.081, p = 0.045), as well as with food availability (r=-0.111, p = 0.006), and food presentation (r=-0.088, p = 0.028). However, no statistically significant relationship was found between food tasting sub-scale scores (p > 0.05). The results of this study reveal the existence of a low level of negative correlation between hedonic hunger and adherence to the Mediterranean diet. Further extensive research is needed concerning individuals residing in diverse geographic locations to gain deeper insights into this subject matter.