bluuebunny/crossref_metadata_2025_split huggingface dataset:
The star-formation history in the last 10 billion years from CIB cross-correlations
Authors: Jego Baptiste , Ruiz-Zapatero Jaime , García-García Carlos , Koukoufilippas Nick , Alonso David 
Published: January 2023

ABSTRACT
The cosmic infrared background (CIB) traces the emission of star-forming galaxies throughout all cosmic epochs. Breaking down the contribution from galaxies at different redshifts to the observed CIB maps would allow us to probe the history of star formation. In this paper, we cross-correlate maps of the CIB with galaxy samples covering the range z ≲ 2 to measure the bias-weighted star-formation rate (SFR) density 〈bρSFR〉 as a function of time in a model independent way. This quantity is complementary to direct measurements of the SFR density ρSFR, giving a higher weight to more massive haloes, and thus provides additional information to constrain the physical properties of star formation. Using cross-correlations of the CIB with galaxies from the DESI Legacy Survey and the extended Baryon Oscillation Spectroscopic Survey, we obtain high signal-to-noise ratio measurements of 〈bρSFR〉, which we then use to place constraints on halo-based models of the star-formation history. We fit halo-based SFR models to our data and compare the recovered ρSFR with direct measurements of this quantity. We find a qualitatively good agreement between both independent data sets, although the details depend on the specific halo model assumed. This constitutes a useful robustness test for the physical interpretation of the CIB, and reinforces the role of CIB maps as valuable astrophysical probes of the large-scale structure. We report our measurements of 〈bρSFR〉 as well as a thorough account of their statistical uncertainties, which can be used to constrain star-formation models in combination with other data.
Photometric and structural parameters of newly discovered nuclear star clusters in Local Volume galaxies
Authors: Hoyer Nils , Neumayer Nadine , Seth Anil C , Georgiev Iskren Y , Greene Jenny E 
Published: January 2023

ABSTRACTWe use high-resolution Hubble Space Telescope imaging data of dwarf galaxies in the Local Volume ($\lesssim {11}\, \mathrm{Mpc}$) to parameterize 19 newly discovered nuclear star clusters (NSCs). Most of the clusters have stellar masses of $M_{\star }^{\mathrm{nsc}} \lesssim 10^{6}{\, {\rm M}_{\odot }}$ and compare to Galactic globular clusters in terms of ellipticity, effective radius, stellar mass, and surface density. The clusters are modelled with a Sérsic profile and their surface brightness evaluated at the effective radius reveals a tight positive correlation to the host galaxy stellar mass. Our data also indicate an increase in slope of the density profiles with increasing mass, perhaps indicating an increasing role for in situ star formation in more massive hosts. We evaluate the scaling relation between the clusters and their host galaxy stellar mass to find an environmental dependence: for NSCs in field galaxies, the slope of the relation is $\alpha = 0.82^{+0.08}_{-0.08}$ whereas $\alpha = 0.55^{+0.06}_{-0.05}$ for dwarfs in the core of the Virgo cluster. Restricting the fit for the cluster to $M_{\star }^{\mathrm{gal}} \ge 10^{6.5}{\, {\rm M}_{\odot }}$ yields $\alpha = 0.70^{+0.08}_{-0.07}$, in agreement with the field environment within the 1σ interval. The environmental dependence is due to the lowest-mass nucleated galaxies and we speculate that this is either due to an increased number of progenitor globular clusters merging to become an NSC, or due to the formation of more massive globular clusters in dense environments, depending on the initial globular cluster mass function. Our results clearly corroborate recent results in that there exists a tight connection between NSCs and globular clusters in dwarf galaxies.
The SOUX AGN sample: SDSS–XMM-Newton optical, ultraviolet, and X-ray selected active galactic nuclei spanning a wide range of parameter space – sample definition
Authors: Kynoch Daniel , Mitchell Jake A J , Ward Martin J , Done Chris , Lusso Elisabeta , Landt Hermine 
Published: January 2023

Abstract
We assemble a sample of 696 type 1 active galactic nuclei (AGN) up to a redshift of z = 2.5, all of which have an SDSS spectrum containing at least one broad emission line (H α, H β, or Mg ii) and an XMM-Newton X-ray spectrum containing at least 250 counts in addition to simultaneous optical/ultraviolet photometry from the XMM Optical Monitor. Our sample includes quasars and narrow-line Seyfert 1s: thus our AGN span a wide range in luminosity, black hole mass, and accretion rate. We determine single-epoch black hole mass relations for the three emission lines and find that they provide broadly consistent mass estimates whether the continuum or emission line luminosity is used as the proxy for the broad emission line region radius. We explore variations of the UV/X-ray energy index αox with the UV continuum luminosity and with black hole mass and accretion rate, and make comparisons to the physical quasar spectral energy distribution model qsosed. The majority of the AGN in our sample lie in a region of parameter space with 0.02 &lt; L/LEdd &lt; 2 as defined by this model, with narrow-line type 1 AGN offset to lower masses and higher accretion rates than typical broad-line quasars. We find differences in the dependence of αox on UV luminosity between both narrow/broad-line and radio-loud/quiet subsets of AGN: αox has a slightly weaker dependence on UV luminosity for broad-line AGN and radio-loud AGN have systematically harder αox.
Determining satellite infall times using machine learning
Authors: Barmentloo Stan , Cautun Marius 
Published: January 2023

ABSTRACT
A key unknown of the Milky Way (MW) satellites is their orbital history, and, in particular, the time they were accreted onto the MW system since it marks the point where they experience a multitude of environmental processes. We present a new methodology for determining infall times, namely using a neural network (NN) algorithm. The NN is trained on MW-analogues in the EAGLE hydrodynamical simulation to predict if a dwarf galaxy is at first infall or a backsplash galaxy and to infer its infall time. The resulting NN predicts with 85-per cent accuracy if a galaxy currently outside the virial radius is a backsplash satellite and determines the infall times with a typical 68-per cent confidence interval of 4.4 Gyr. Applying the NN to MW dwarfs with Gaia EDR3 proper motions, we find that all of the dwarfs within 300 kpc had been inside the Galactic halo. The overall MW satellite accretion rate agrees well with the theoretical prediction except for late times when the MW shows a second peak at a lookback time of 1.5 Gyr corresponding to the infall of the LMC and its satellites. We also find that the quenching times for ultrafaint dwarfs show no significant correlation with infall time and thus supporting the hypothesis that they were quenched during reionization. In contrast, dwarfs with stellar masses above 105 M⊙ are found to be consistent with environmental quenching inside the Galactic halo, with star-formation ceasing on average at $0.5^{+0.9}_{-1.2}$ Gyr after infall.
MOCCA-Survey Database: extra galactic globular clusters – III. The population of black holes in Milky Way and Andromeda-like galaxies
Authors: Leveque A , Giersz M , Askar Abbas , Arca-Sedda M , Olejak A 
Published: January 2023

ABSTRACT
This work investigates the black hole (BH) population of globular clusters (GCs) in Milky Way- and Andromeda-like galaxies. We combine the population synthesis code MASinGa and the MOCCA-Survey Database I to infer the properties of GCs harbouring a stellar-mass BH subsystem (BHS), an intermediate-mass BH (IMBH), or neither of those. We find that the typical number of GCs with a BHS, an IMBH, or none become comparable in the galactic outskirts, whilst the inner galactic regions are dominated by GCs without a significant dark component. We retrieve the properties of binary BHs (BBHs) that have either merged in the last 3 Gyr or survived in their parent cluster until present-day. We find that around 80 per cent of the merging BBHs form due to dynamical interactions while the remaining originate from evolution of primordial binaries. The inferred merger rate for both in-cluster and ejected mergers is $1.0\!-\!23\, \, \rm {yr^{-1}\, Gpc^{-3}}$ in the local Universe, depending on the adopted assumptions. We find around 100–240 BBHs survive in GCs until present-day and are mostly concentrated in the inner few kpc of the galaxy. When compared with the field, GCs are at least two times more efficient in the formation of BHs and binaries containing at least one BH. Around 1000–3000 single BHs and 100–200 BBHs are transported into the galactic nucleus from infalling clusters over a time span of 12 Gyr. We estimate that the number of BHs and BBHs lurking in the star cluster to be about 1.4–2.2 × 104 and 700–1100, respectively.
Multiomics approach to profiling Sertoli cell maturation during development of the spermatogonial stem cell niche
Authors: Voigt A L , Dardari R , Lara N L M , He T , Steele H , Dufour A , Orwig K E , Dobrinski I 
Published: January 2023

AbstractSpermatogonial stem cells (SSCs) are the basis of spermatogenesis, a complex process supported by a specialized microenvironment, called the SSC niche. Postnatal development of SSCs is characterized by distinct metabolic transitions from prepubertal to adult stages. An understanding of the niche factors that regulate these maturational events is critical for the clinical application of SSCs in fertility preservation. To investigate the niche maturation events that take place during SSC maturation, we combined different ‘-omics’ technologies. Serial single cell RNA sequencing analysis revealed changes in the transcriptomes indicative of niche maturation that was initiated at 11 years of age in humans and at 8 weeks of age in pigs, as evident by Monocle analysis of Sertoli cells and peritubular myoid cell (PMC) development in humans and Sertoli cell analysis in pigs. Morphological niche maturation was associated with lipid droplet accumulation, a characteristic that was conserved between species. Lipidomic profiling revealed an increase in triglycerides and a decrease in sphingolipids with Sertoli cell maturation in the pig model. Quantitative (phospho-) proteomics analysis detected the activation of distinct pathways with porcine Sertoli cell maturation. We show here that the main aspects of niche maturation coincide with the morphological maturation of SSCs, which is followed by their metabolic maturation. The main aspects are also conserved between the species and can be predicted by changes in the niche lipidome. Overall, this knowledge is pivotal to establishing cell/tissue-based biomarkers that could gauge stem cell maturation to facilitate laboratory techniques that allow for SSC transplantation for restoration of fertility.
Long-term safety and efficacy of E6011, an anti-fractalkine monoclonal antibody, in patients with rheumatoid arthritis inadequately responding to methotrexate
Authors: Tanaka Yoshiya , Takeuchi Tsutomu , Yamanaka Hisashi , Nanki Toshihiro , Umehara Hisanori , Yasuda Nobuyuki , Tago Fumitoshi , Kitahara Yasumi , Kawakubo Makoto , Torii Kentaro , Hojo Seiichiro , Kawano Tetsu , Imai Toshio 
Published: January 2023

ABSTRACT

Objectives
To evaluate the long-term safety and efficacy of E6011, a humanized anti-fractalkine monoclonal antibody, in patients with rheumatoid arthritis (RA) with an inadequate response to methotrexate (MTX).

Methods
Active RA patients with an inadequate response to MTX were randomly assigned to the E6011 or placebo group and received the study drug subcutaneously every 2 weeks during a 24-week double-blind study period. Subjects who completed evaluations at Week 24 were rolled over into the extension phase and received open-label E6011 (200 or 400 mg) every 2 weeks until Week 102. The safety analysis was conducted up to Week 104, and the efficacy analysis was conducted up to Week 84.

Results
A total of 169 subjects completed the double-blind treatment phase and were rolled over into the extension phase. In total, 167 (98.8%) subjects experienced any adverse events, and the incidence of treatment-related adverse events was 56.2%. The American College of Rheumatology 20 response rates were observed between 40 and 70% during the extension phase.

Conclusions
E6011 was safe and well tolerated with no notable safety concerns up to 102 weeks in RA patients with an inadequate response to MTX.
PREDICT-crFMF score: A novel model for predicting colchicine resistance in children with familial Mediterranean fever
Authors: Aktay Ayaz Nuray , Demirkan Fatma Gül , Coşkuner Taner , Demir Ferhat , Tanatar Ayşe , Çakan Mustafa , Karadağ Şerife Gül , Yener Gülçin Otar , Öztürk Kübra , Bağlan Esra , Çakmak Figen , Çağlayan Şengül , Özdel Semanur , Ulu Kadir , Sözeri Betül , Sönmez Hafize Emine 
Published: January 2023

ABSTRACT

Objectives
To develop a novel scoring system to predict colchicine resistance in Familial Mediterranean fever (FMF) based on the initial features of the patients.

Methods
The medical records of patients were analyzed prior to the initiation of colchicine. After generating a predictive score in the initial cohort, it was applied to an independent cohort for external validation of effectiveness and reliability.

Results
Among 1418 patients with FMF, 56 (3.9%) were colchicine resistant (cr) and 1312 (96.1%) were colchicine responsive. Recurrent arthritis (4 points), protracted febrile myalgia (8 points), erysipelas-like erythema (2 points), exertional leg pain (2 points), and carrying M694V homozygous mutation (4 points) were determined as the parameters for predicting cr-FMF in the logistic regression model. The cut-off value of 9 was 87% sensitive and 82% specific to foresee the risk of cr-FMF in the receiver operating characteristic. Validation of the scoring system with an independent group (cr-FMF = 107, colchicine responsive = 1935) revealed that the cut-off value was 82% sensitive and 79% specific to identify the risk of cr-FMF.

Conclusions
By constructing this reliable and predictor tool, we enunciate that predicting cr-FMF at the initiation of the disease and interfering timely before the emergence of complications will be possible.
H2O-Controlled Eruptive Filtering on the Bimodality of Continental Volcanism Across Tectonic Settings
Authors: Zhao Kai , Xu Xisheng , Bachmann Olivier , Nan Tongchao , Xia Yan 
Published: January 2023

Abstract
The contemporary basaltic and rhyolitic volcanism with a dearth of intermediate compositions creates a compositional gap (‘Daly gap’), which is known to be pronounced in continental rifts/hotspots but absent in continental arcs. The intrinsic mechanism(s) producing the Daly gap remain poorly understood. Similar bimodal spectra recorded in melt inclusions from continental rifts/hotspots and arcs suggest that similar processes modulate the bulk composition of erupted magmas. A compiled data set of melt inclusion composition, phenocryst fraction, pre-eruptive temperature and melt H2O content enables precise calculations of melt viscosities and bulk magma viscosities for &gt;100 eruptions of global volcanoes in various tectonic settings. Analyses of the data set suggest lower viscosities of rhyolitic melts in arcs than in rifts/hotspots (~104.5 ± 0.2 versus ~105.5 ± 0.2 Pa·s, respectively), at comparable temperatures, because of ~1.5 wt % higher melt H2O contents in arcs. Combining numerical constraints on ascent dynamics and data set observations, our study defines an eruption threshold of ~106.0 ± 0.3 Pa·s at the base of a volcanic conduit rooted in the subvolcanic reservoir. The lower viscosities of rhyolitic melts in arcs facilitate stirring/re-homogenization of upper crustal reservoirs upon recharge and accommodation of more phenocrysts in erupted products, leading to the common appearance of crystal-rich (30–50%) andesites and dacites (with rhyolitic interstitial melts) with mixing signatures in magmatic provinces of continental arcs. In contrast, the lower mixing efficiency and eruptibility of the more viscous magmas present in continental rifts/hotspots lead to preferential eruption of crystal-poor (&lt;~30%) rhyolites, enhancing compositional bimodality in the erupted records. This H2O-controlled eruptive filter modulates the presence versus absence of the Daly gap and is key to the distinct differentiation patterns across tectonic settings.
Mechanisms of pathogenicity in the hypertrophic cardiomyopathy-associated TPM1 variant S215L
Authors: Halder Saiti S , Rynkiewicz Michael J , Creso Jenette G , Sewanan Lorenzo R , Howland Lindsey , Moore Jeffrey R , Lehman William , Campbell Stuart G 
Published: January 2023

Abstract
Hypertrophic cardiomyopathy (HCM) is an inherited disorder often caused by mutations to sarcomeric genes. Many different HCM-associated TPM1 mutations have been identified but they vary in their degrees of severity, prevalence, and rate of disease progression. The pathogenicity of many TPM1 variants detected in the clinical population remains unknown. Our objective was to employ a computational modeling pipeline to assess pathogenicity of one such variant of unknown significance, TPM1 S215L, and validate predictions using experimental methods. Molecular dynamic simulations of tropomyosin on actin suggest that the S215L significantly destabilizes the blocked regulatory state while increasing flexibility of the tropomyosin chain. These changes were quantitatively represented in a Markov model of thin-filament activation to infer the impacts of S215L on myofilament function. Simulations of in vitro motility and isometric twitch force predicted that the mutation would increase Ca2+ sensitivity and twitch force while slowing twitch relaxation. In vitro motility experiments with thin filaments containing TPM1 S215L revealed higher Ca2+ sensitivity compared with wild type. Three-dimensional genetically engineered heart tissues expressing TPM1 S215L exhibited hypercontractility, upregulation of hypertrophic gene markers, and diastolic dysfunction. These data form a mechanistic description of TPM1 S215L pathogenicity that starts with disruption of the mechanical and regulatory properties of tropomyosin, leading thereafter to hypercontractility and finally induction of a hypertrophic phenotype. These simulations and experiments support the classification of S215L as a pathogenic mutation and support the hypothesis that an inability to adequately inhibit actomyosin interactions is the mechanism whereby thin-filament mutations cause HCM.
Metaverse, mental health and museums in post-COVID-19
Authors: Kahambing Jan Gresil 
Published: January 2023

Abstract
In this article, I extend the modalities of mental health integration to the metaverse further toward the alternative case of museums. Some countries have modeled health facilitations of psychological nature to museums either physically or virtually. The metaverse as the incorporation of digital and actual bodies poses a further philosophical question of addressing the network of institutional and personal somatic modifications in the post-COVID-19 era.
Effects of faecal microbiota transplantation on the small intestinal mucosa in systemic sclerosis
Authors: Strahm Noemi , Didriksen Henriette , Fretheim Håvard , Molberg Øyvind , Midtvedt Øyvind , Farstad Inger Nina , Midtvedt Tore , Lundin Knut E A , Aabakken Lars , Błyszczuk Przemysław , Distler Oliver , Kania Gabriela , Hoffmann-Vold Anna-Maria 
Published: January 2023

Abstract

Objectives
In SSc, gastrointestinal tract (GIT) involvement is a major concern, with no disease-modifying and limited symptomatic therapies available. Faecal microbiota transplantation (FMT) represents a new therapeutic option for GIT-affliction in SSc, showing clinical promise in a recent controlled pilot trial. Here, we aim to investigate effects of FMT on duodenal biopsies collected from SSc patients by immunohistochemistry and transcriptome profiling.

Methods
We analysed duodenal biopsies obtained pre-intervention (week 0) and post-intervention (weeks 2 and 16) from nine SSc patients receiving an intestinal infusion of FMT (n = 5) or placebo (n = 4). The analysis included immunohistochemistry (IHC) with a selected immune function and fibrosis markers, and whole biopsy transcriptome profiling.

Results
In patients receiving FMT, the number of podoplanin- and CD64-expressing cells in the mucosa were lower at week 2 compared with baseline. This decline in podoplanin- (r = 0.94) and CD64-positive (r = 0.89) cells correlated with improved patient-reported lower GIT symptoms. Whole biopsy transcriptome profiling from week 2 showed significant enrichment of pathways critical for cellular and endoplasmic reticulum stress responses, microvillus and secretory vesicles, vascular and sodium-dependent transport, and circadian rhythm. At week 16, we found enrichment of pathways mandatory for binding activity of immunoglobulin receptors, T cell receptor complexes, and chemokine receptors, as well as response to zinc-ions. We found that 25 genes, including Matrix metalloproteinase-1 were upregulated at both week 2 and week 16.

Conclusion
Combining selective IHC and unbiased gene expression analyses, this exploratory study highlights the potential for disease-relevant organ effects of FMT in SSc patients with GIT involvement.

Trial registration
ClinicalTrials.gov, http://clinicaltrials.gov, NCT03444220.
Classification of patients with osteoarthritis through clusters of comorbidities using 633 330 individuals from Spain
Authors: Pineda-Moncusí Marta , Dernie Francesco , Dell’Isola Andrea , Kamps Anne , Runhaar Jos , Swain Subhashisa , Zhang Weiya , Englund Martin , Pitsillidou Irene , Strauss Victoria Y , Robinson Danielle E , Prieto-Alhambra Daniel , Khalid Sara 
Published: January 2023

Abstract

Objectives
To explore clustering of comorbidities among patients with a new diagnosis of OA and estimate the 10-year mortality risk for each identified cluster.

Methods
This is a population-based cohort study of individuals with first incident diagnosis of OA of the hip, knee, ankle/foot, wrist/hand or ‘unspecified’ site between 2006 and 2020, using SIDIAP (a primary care database representative of Catalonia, Spain). At the time of OA diagnosis, conditions associated with OA in the literature that were found in ≥1% of the individuals (n = 35) were fitted into two cluster algorithms, k-means and latent class analysis. Models were assessed using a range of internal and external evaluation procedures. Mortality risk of the obtained clusters was assessed by survival analysis using Cox proportional hazards.

Results
We identified 633 330 patients with a diagnosis of OA. Our proposed best solution used latent class analysis to identify four clusters: ‘low-morbidity’ (relatively low number of comorbidities), ‘back/neck pain plus mental health’, ‘metabolic syndrome’ and ‘multimorbidity’ (higher prevalence of all studied comorbidities). Compared with the ‘low-morbidity’ cluster, the ‘multimorbidity’ cluster had the highest risk of 10-year mortality (adjusted hazard ratio [HR]: 2.19 [95% CI: 2.15, 2.23]), followed by the ‘metabolic syndrome’ cluster (adjusted HR: 1.24 [95% CI: 1.22, 1.27]) and the ‘back/neck pain plus mental health’ cluster (adjusted HR: 1.12 [95% CI: 1.09, 1.15]).

Conclusion
Patients with a new diagnosis of OA can be clustered into groups based on their comorbidity profile, with significant differences in 10-year mortality risk. Further research is required to understand the interplay between OA and particular comorbidity groups, and the clinical significance of such results.