bluuebunny/crossref_metadata_2025_split huggingface dataset:
The use of phytobiotics in fish feeding as an alternative to antibacterial and probiotic preparations (review)
Authors: Miroshnikova E. P. , Arinzhanov A. E. , Kilyakova Yu. V. , Sizentsov A. N. 
Published: August 2023

Relevance. The use of antibacterial drugs as feed additives for many years has made it possible to reduce the risk of developing infectious pathologies and, as a result, increased the productivity of the industry, in addition to obvious advantages, the constant use of antibiotics develops bacterial resistance, negatively affects representatives of the normoflora of biocenoses and has an accumulating effect in aquaculture. One of the possible ways to increase productivity is the use of probiotic strains with pronounced antagonistic characteristics against pathogenic microorganisms. It should be noted that for optimal fish growth, a high level of species-specificity of the structural microbiome is necessary, which ultimately cannot guarantee the effectiveness of the use of commercial probiotic drugs in fish feeding diets.Results. The presented scientific data on the use of phytobiotics indicate not only a pronounced effect stimulating the growth of fish, but also a high antioxidant and immunostimulating effect. Separately, it is worth noting the high level of effectiveness of the tested plants against pathogenic strains of A. hydrophila microorganisms (purslane leaf powder; dogwood fruit extract; a combination of essential oils of thyme, red thyme and rosemary pepper; food nanoparticles of cinnamon, a combination of extracts of coriander, mallow, oak acorn; pandanus roofing extract), A. veronii (apricot seed powder), L. monocytogenes (basil clove leaf extract), S. agalactiae (Belgian quince fruit extract). Hypothetically, this mechanism can be explained not only by the activation of indicators of nonspecific immunity, but also by the influence of the majority of plants tested in experiments with the anti Quorum Sensing effect. This review is aimed at describing the global trend in the use of phytobiotics in fish feeding.
The effect of feed additives on the hematological and productive qualities of young cattle
Authors: Fatkullin R. R. , Belookov A. A. , Ermolova E. M. , Rebezov M. B. , Maksimova R. A. 
Published: August 2023

Relevance. The development of cattle breeding and the production of high-quality beef in Russia is currently one of the important tasks. This paper presents the results of studies on the effect of a feed additive based on colostrum oil, protein hydrolysate and vitamins on the morphological and biochemical parameters of the blood of young animals.Methods. The diet of animals of the experimental group included a feed additive, which includes colostrum oil, protein hydrolysate and vitamins. The feed additive was introduced into the daily diet at a dose of 100 g per head per day. It has been established that the introduction of a feed additive into the diet of young animals has a positive effect on the morphological and biochemical composition of blood, contributes to increasing the productivity of young cattle.Results. The results of scientific and economic experience have shown that the use of feed additives in the feeding of young cattle is an effective method of reducing productivity losses during cultivation and contributes to improving the productive qualities of farm animals.
Geleneğin İzinde Mutasavvıf Şâir Ömer Necmî Efendi ve Şem‘a-Nâmesi
Authors: ÖZTÜRK Mehmet , GÖKTAŞ Mehmet 
Published: August 2023

Ömer Necmi Efendi, XIX. asırda geleneğin izinde eserler veren mutasavvıf bir şairdir. Rind meşrep bir şair olan Necmî, eserlerini tasavvufi neşveyle yazmıştır. Manzumelerinde sade bir üslup kullanmıştır. Şiirlerini büyük oranda aruzla kaleme almakla birlikte Türkçe Divanı’nda hece vezniyle yazdığı şiirler de vardır.
Necmi’nin Şem‘a-nâme ismini verdiği manzumesi alegorik tarzda tanzim edilmiş bir kasidedir. Bu manzume sual-cevap şeklinde iki bölümden meydana gelmektedir. Manzumede şem‘a (mum) kişileştirilir ve intak sanatıyla bidayetten nihayete şem’anın başından geçen macera dile getirilir. Necmî’nin Şem‘a-nâmesi edebî geleneğimizdeki Şem‘u Pervâne mesnevilerini çağrıştırsa da âşık-maşuk ilişkisi üzerine kurulmuş bir metin değildir. Manzume sadece şem‘anın oluşum ve gelişim sürecini konu edinir. Edebî tür ve şekiller içinde böyle bir türe rastlanılmadığından diğer türler gibi müstakil edebî bir tür olarak değerlendirmek çok zordur.
Bu makalede Necmî’nin müstakil olarak nazmettiği Şem‘a-nâme eseri incelenmiştir. Çalışmanın giriş bölümünde “şem‘/mum” hakkında bilgi verilmiş, akabinde Necmî’nin hayatı yazılmıştır. Daha sonra Şem‘a-nâme’nin yazma nüshaları tanıtılmış, eserin muhtevası hakkında bilgi verilmiş ve eserin transkripsiyonu yapılarak dil içi çevirisine yer verilmiştir.
PENERAPAN MWMOTE UNTUK MENGATASI KETIDAKSEIMBANGAN KELAS PADA KLASIFIKASI RISIKO KREDIT
Authors: Ulfah Maria , Saragih Triando Hamonangan , Kartini Dwi , Mazdadi Muhammad Itqan , Abadi Friska 
Published: August 2023

Salah satu bentuk usaha yang dijalankan oleh perbankan adalah pemberian kredit terhadap nasabaah. Bank akan selalu berusaha mengoptimalkan penyaluran kredit terhadap nasabah, akan tetapi tidak menutup kemungkinan bahwa kredit yang diberikan tersebut memiliki risiko. Guna menekan dan meminimalisir risiko kredit pihak bank perlu melakukan analisis terhadap data yang dimiliki nasabah agar dapat mengambil keputusan apakah nasabah atau calon debitur layak diberikan pinjaman dalam bentuk kredit. Salah satu cara untuk menyelesaikan masalah analisa risiko kredit adalah dengan melakukan klasifikasi dengan menggunakan machine learning. Pada penelitian ini dilakukan klasifikasi dengan menggunakan algoritma Support Vector Machine (SVM) serta oversampling data dengan menggunakan MWMOTE dan Improve MWMOTE. Data yang digunakan pada penelitian ini adalah data german credit risk yang memiliki Kelas bad credit yang terdiri atas 300 data dan kelas good credit terdiri atas 700 data. Penelitian dilakukan dengan membandingkan klasifikasi SVM dengan dan tanpa oversampling. Hasilnya didapatkan bahwa nilai akurasi dari klasifikasi Improve MWMOTE SVM memiliki nilai tertinggi jika dibandingan dengan SVM MWMOTE, dan SVM yaitu sebesar 77,95%.
PERBANDINGAN ALGORITMA C4.5 DAN SVM DALAM KLASIFIKASI PENYAKIT ANEMIA
Authors: Yanti Dina Elly , Framesti Lizah , Desiani Anita 
Published: August 2023

Anemia merupakan keadaan saat hemoglobin pada tubuh tidak dapat berfungsi dengan baik. Anemia berdampak buruk bagi kesehatan, salah satunya pada daya tahan tubuh. Untuk mencegah terjadinya penyakit anemia dapat dilakukan deteksi dini dengan memanfaatkan pendekatan matematika menggunakan data mining. Data mining memiliki metode-metode klasifikasi yang bisa digunakan untuk deteksi dini penyakit anemia. Metode yang bisa digunakan untuk klasifikasi diantaranya yaitu algoritma Support Vector Machines (SVM) dan algoritma C4.5. Penelitian ini menerapkan algoritma SVM dan algoritma C4.5 untuk klasifikasi deteksi dini penyakit anemia. Tujuan penelitian ini adalah mendapatlkan metode paling tepat antara algoritma SVM dan algoritma C4.5 dalam klasifikasi penyakit anemia. Penelitian ini menerapkan teknik pengujian percentage split dan k-fold cross validation. Pada percentage split dipilih split sebesar 80% sebagai data latih dan 20% sebagai data uji. Pada k-fold cross validation dipilih nilai k sebesar 10. Hasil penerapan kedua metode menunjukkan bahwa k-fold cross validation bekerja lebih baik dibandingkan percentage split dengan persentase nilai akurasi, presisi, dan recall lebih tinggi dari masing-masing algoritma. Untuk kinerja kedua algoritma, C4.5 dalam penerapannya bekerja lebih baik dengan nilai akurasi, presisi, dan recall secara berturut-turut, yaitu 99.29%, 98.7%, dan 99.69% dibandingkan algoritma SVM. Dari hasil yang diperoleh dapat disimpulkan bahwa algoritma C4.5 dengan teknik pengujian k-fold cross validation menghasilkan nilai performa yang paling baik untuk klasifikasi penyakit anemia dibanding algoritma dan teknik pengujian lainnya.
Eficacia de biopsia de ganglio centinela en cáncer de mama posterior a quimioterapia neoadyuvante como predictor de estadificación axilar.
Authors: Malatay González Carlos Humberto , Apolo Carrión Cinthya Abigail , Carofilis Gallo Felix Josué , Zamora Villavicencio Maria Elena 
Published: August 2023

Introducción: La biopsia selectiva del ganglio centinela (BSGC) en cáncer de mama es el método estándar para estadificación axilar en pacientes con axila clínicamente negativa. Estudios indican evitar linfadenectomía axilar en pacientes con BSGC negativas incluyendo aquellos que recibieron previamente quimioterapia neoadyuvante (QTN). El objetivo del presente estudio es determinar la eficacia de la BSGC en detectar ganglios centinela posterior QTN en un instituto oncológico de referencia en Ecuador.
Materiales y Métodos: Estudio observacional, analítico y retrospectivo, realizado en Hospital SOLCA Guayaquil, durante el período enero 2015 a diciembre 2020. Se evaluaron 81 pacientes con cáncer de mama con axila clínicamente negativa que recibieron QTN previo a cirugía. Las variables son biopsia de ganglio centinela, quimioterapia neoadyuvante, precisión diagnóstica y estadificación axilar. Se consideró el Odds Ratio del 95%, con una P<0.05.
Resultados: De 81 pacientes operados, 52 pacientes recibieron BSGC con muestreo detectándose ganglio centinela en 92.3% de los casos. El porcentaje de falsos negativos es 21.7% posterior a QTN. Los 29 pacientes restantes recibieron linfadenectomía axilar.
Conclusión: La BSGC es efectiva para detectar el ganglio centinela en pacientes con cáncer de mama y axila clínicamente negativa, incluso después de la quimioterapia neoadyuvante. Sin embargo, existe un riesgo significativo de falsos negativos después de la QTN, lo que puede llevar a la necesidad de realizar una linfadenectomía axilar adicional para una evaluación más precisa de la estadificación axilar.
Delivery of multipotent adult progenitor cells via a functionalized plasma polymerized surface accelerates healing of murine diabetic wounds
Authors: Mills S. J. , Kirby G. T. , Hofma B. R. , Smith L. E. , Statham P. , Vaes B. , Ting A. E. , Short R. , Cowin A. J. 
Published: August 2023

Introduction: Stem cell therapies have been investigated as potential treatment modalities for chronic wounds however there has been limited success to date. Multipotent Adult Progenitor Cells (MAPCs©) have been identified as having potential as an allogenic stem cell product due to their high population doubling number and their characteristic dampening of T-cell proliferation. This helps to prevent autoimmunity and graft/cell rejection.Methods: We have developed a dressing, consisting of medical grade silicone coated with a heptylamine plasma polymer, which supports the growth and transfer of MAPCs to skin. To determine if the dressing can deliver functional stem cells into diabetic wounds, they were loaded with MAPCs and then placed over excisional wounds in both normal and diabetic mice.Results and discussion: Accelerated healing was observed in both the normal and diabetic wounds with wound gape being significantly smaller at day 3 when compared to controls. Wound analysis showed that treatment with the MAPC dressings dampened the inflammatory response with reduced numbers of neutrophils and macrophages observed. Additionally, an increase in pro-angiogenic VEGF and CD31 positive endothelial cells was observed indicating improved new blood vessel formation. The MAPC dressings had no effect on fibrosis with collagen I and III being equally affected in both control and treated wounds. Overall, the functionalized MAPC dressings improve healing responses particularly in diabetic mice with impaired healing responses and therefore, show potential for development as an advanced therapeutic approach for the treatment of chronic diabetic wounds.
MoS2 nanobelts-carbon hybrid material for supercapacitor applications
Authors: Khandare Lina N. , Late Dattatray J. , Chaure Nandu B. 
Published: August 2023

The MoS2 nanobelts/Carbon hybrid nanostructure was synthesized by the simple hydrothermal method. The MoS2 nanobelts were distributed in the interlayers of Lemon grass-derived carbon (LG-C), provides the active sites and avoid restacking of the sheets. The structural and morphological characterization of MoS2/LG-C and LG-C were performed by Raman spectroscopy, X-ray diffraction, field emission scanning electron microscopy, transmission electron microscopy, and X-ray photoelectron spectroscopy. The electrochemical measurements were studied with cyclic voltammetry, the galvanostatic charge-discharge method, and electrochemical impedance spectroscopy. The specific capacitance of MoS2/LG-C and LG-C exhibits 77.5 F g−1 and 30.1 F g−1 at a current density of 0.5 A g−1. The MoS2/LG-C-based supercapacitor provided the maximum power density and energy density of 273.2 W kg−1 and 2.1 Wh kg−1, respectively. Furthermore, the cyclic stability of MoS2/LG-C was tested using charging-discharging up to 3,000 cycles, confirming only a 71.6% capacitance retention at a current density of 3 A g−1. The result showed that MoS2/LG-C is a superior low-cost electrode material that delivered a high electrochemical performance for the next generation of electrochemical energy storage.
Whole exome sequencing highlights rare variants in CTCF, DNMT1, DNMT3A, EZH2 and SUV39H1 as associated with FSHD
Authors: Strafella Claudia , Caputo Valerio , Bortolani Sara , Torchia Eleonora , Megalizzi Domenica , Trastulli Giulia , Monforte Mauro , Colantoni Luca , Caltagirone Carlo , Ricci Enzo , Tasca Giorgio , Cascella Raffaella , Giardina Emiliano 
Published: August 2023

Introduction: Despite the progress made in the study of Facioscapulohumeral Dystrophy (FSHD), the wide heterogeneity of disease complicates its diagnosis and the genotype-phenotype correlation among patients and within families. In this context, the present work employed Whole Exome Sequencing (WES) to investigate known and unknown genetic contributors that may be involved in FSHD and may represent potential disease modifiers, even in presence of a D4Z4 Reduced Allele (DRA).Methods: A cohort of 126 patients with clinical signs of FSHD were included in the study, which were characterized by D4Z4 sizing, methylation analysis and WES. Specific protocols were employed for D4Z4 sizing and methylation analysis, whereas the Illumina® Next-Seq 550 system was utilized for WES. The study included both patients with a DRA compatible with FSHD diagnosis and patients with longer D4Z4 alleles. In case of patients harboring relevant variants from WES, the molecular analysis was extended to the family members.Results: The WES data analysis highlighted 20 relevant variants, among which 14 were located in known genetic modifiers (SMCHD1, DNMT3B and LRIF1) and 6 in candidate genes (CTCF, DNMT1, DNMT3A, EZH2 and SUV39H1). Most of them were found together with a permissive short (4–7 RU) or borderline/long DRA (8–20 RU), supporting the possibility that different genes can contribute to disease heterogeneity in presence of a FSHD permissive background. The segregation and methylation analysis among family members, together with clinical findings, provided a more comprehensive picture of patients.Discussion: Our results support FSHD pathomechanism being complex with a multigenic contribution by several known (SMCHD1, DNMT3B, LRIF1) and possibly other candidate genes (CTCF, DNMT1, DNMT3A, EZH2, SUV39H1) to disease penetrance and expressivity. Our results further emphasize the importance of extending the analysis of molecular findings within the proband’s family, with the purpose of providing a broader framework for understanding single cases and allowing finer genotype-phenotype correlations in FSHD-affected families.
Immediate postpartum family planning utilization and its associated factors among postpartum women in Ethiopia: a systematic review and meta-analysis
Authors: Silesh Mulualem , Demisse Tesfanesh Lemma , Taye Birhan Tsegaw , Moltot Tebabere , Chekole Moges Sisay , Wogie Girma , Kasahun Fetene , Adanew Solomon 
Published: August 2023

BackgroundFamily planning integration in areas where women contact the healthcare system routinely is essential for addressing the high unmet need for family planning among postpartum women and reducing the risk of short interpregnancies. Immediate postpartum family planning (IPPFP) is an integrated service, and opportunities exist for women by providing family planning (FP) counseling and contraceptives as part of care following childbirth within 48 h. Therefore, this review aimed to assess the pooled estimate of immediate postpartum family planning utilization and its associated factors in Ethiopia.MethodElectronic databases were used to conduct an extensive search of all published studies, and the digital library was used to identify any unpublished studies. An observational study that reports the prevalence/magnitude and/or associated factors/predictors/determinants of IPPFP utilization in Ethiopia was included. Data were extracted on the Microsoft Excel spreadsheet and analyzed using STATA Version 11. A random-effects model was applied to determine the pooled prevalence of immediate postpartum family planning utilization with a 95% confidence interval (CI). Inverse variance (I2) was used to identify the presence of heterogeneity, and a funnel plot and Egger's test were used to check the presence of publication bias. Subgroup analysis was conducted based on the sample size, region, and year of study to identify the source of heterogeneity.ResultOf 15 primary studies, the overall pooled prevalence of immediate postpartum family planning utilization among postpartum women in Ethiopia was 21.04% (95% CI: 13.08, 29.00). Received counseling on FP [OR: 3.59; 95% CI (1.84, 7.01; P &lt; 0.001), having a positive attitude toward FP [OR: 3.2; 95% CI (1.23, 8.35); P = 0.017], and partner support to use FP [OR: 5.85; 95% CI (1.12, 30.54; P = 0.036) were significant predictors of immediate postpartum family planning utilization.ConclusionGenerally, IPPFP utilization in Ethiopia was insufficient. Therefore, to enhance the utilization, integrating FP counseling at all maternal service care points, strengthening community awareness to develop a favorable attitude toward family planning, and promoting partner involvement in family planning counseling are essential.
Systematic Review Registrationhttps://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=239053, identifier: CRD42021239053.
Immunometabolic actions of trabectedin and lurbinectedin on human macrophages: relevance for their anti-tumor activity
Authors: Povo-Retana Adrián , Fariñas Marco , Landauro-Vera Rodrigo , Mojena Marina , Alvarez-Lucena Carlota , Fernández-Moreno Miguel A. , Castrillo Antonio , de la Rosa Medina Juan Vladimir , Sánchez-García Sergio , Foguet Carles , Mas Francesc , Marin Silvia , Cascante Marta , Boscá Lisardo 
Published: August 2023

In recent years, the central role of cell bioenergetics in regulating immune cell function and fate has been recognized, giving rise to the interest in immunometabolism, an area of research focused on the interaction between metabolic regulation and immune function. Thus, early metabolic changes associated with the polarization of macrophages into pro-inflammatory or pro-resolving cells under different stimuli have been characterized. Tumor-associated macrophages are among the most abundant cells in the tumor microenvironment; however, it exists an unmet need to study the effect of chemotherapeutics on macrophage immunometabolism. Here, we use a systems biology approach that integrates transcriptomics and metabolomics to unveil the immunometabolic effects of trabectedin (TRB) and lurbinectedin (LUR), two DNA-binding agents with proven antitumor activity. Our results show that TRB and LUR activate human macrophages toward a pro-inflammatory phenotype by inducing a specific metabolic rewiring program that includes ROS production, changes in the mitochondrial inner membrane potential, increased pentose phosphate pathway, lactate release, tricarboxylic acids (TCA) cycle, serine and methylglyoxal pathways in human macrophages. Glutamine, aspartate, histidine, and proline intracellular levels are also decreased, whereas oxygen consumption is reduced. The observed immunometabolic changes explain additional antitumor activities of these compounds and open new avenues to design therapeutic interventions that specifically target the immunometabolic landscape in the treatment of cancer.
Protocol for the safety and efficacy of fecal microbiota transplantation liquid in children with autism spectrum disorder: a randomized controlled study
Authors: Wei Jinying , Chen Jiayi , Fang Xiaohui , Liu Tianyu , Yuan Yanhan , Zhang Jinping 
Published: August 2023

BackgroundAutism Spectrum Disorder (ASD) is a neurodevelopmental disorder characterized by deficits in social interaction, repetitive behavior and language impairment, and its worldwide prevalence has been found to be increasing annually in recent years. Till now, ASD is uncurable as its pathogenesis remains unknown. However, studies on both animals and humans have demonstrated that fecal microbiota transplantation (FMT) may ameliorate the symptoms of ASD, as well as gastrointestinal symptoms. Nonetheless, there is still no agreement regarding the optimal dosage or duration of FMT treatment for individuals with ASD.MethodsThis clinical study is a double-blind, randomized, interventional trial conducted at a single center. The aim is to investigate the safety and efficacy of a pediatric formulation of FMT for ASD. A total of 42 children between the ages of 3–9 with ASD will be randomly assigned in a 2:1 ratio to either an FMT treatment group (n = 28) or a placebo group (n = 14), forming cohort 1. Additionally, 30 healthy children of similar age and gender will be recruited as the control group (cohort 2). Cohort 1 will be assessed using a variety of scales, including the Autism Behavior Checklist, Childhood Autism Rating Scale, Social Responsiveness Scale, Gastrointestinal Symptom Rating Scale, Children’s Sleep Habits Questionnaire, and Psychoeducational Profile (Third Edition). These assessments will evaluate the effectiveness of FMT in reducing core symptoms and comorbidities (such as gastrointestinal symptoms and sleep disturbances) in children with ASD. The study will use metagenomic and metabolomic sequencing to assess changes in the composition and structure of the intestinal flora and its metabolites in blood, urine, and feces following treatment. Furthermore, the study will evaluate the acceptability of the FMT formulation by participants’ legal guardians and investigate differences in the intestinal flora and metabolism in the FMT group before and after treatment compared to 30 healthy children.Clinical trial registrationhttps://www.chictr.org.cn/, identifier ChiCTR2200058459.