bluuebunny/crossref_metadata_2025_split huggingface dataset:
A systematic and comprehensive analysis of T cell exhaustion related to therapy in lung adenocarcinoma tumor microenvironment
Authors: Hu Peipei , Ma Jiahao , Chen Jinjian 
Published: February 2023

Background: T cell exhaustion (TEX) is an important immune escape mechanism, and an in-depth understanding of it can help improve cancer immunotherapy. However, the prognostic role of TEX in malignant lung adenocarcinoma (LUAD) remains unclear.Methods: Through TCGA and GEO datasets, we enrolled a total of 498 LUAD patients. The patients in TCGA-LUAD were unsupervised clustered into four clusters according to TEX signaling pathway. WGCNA analysis, survival random forest analysis and lasso regression analysis were used to select five differentially expressed genes among different clusters to construct a TEX risk model. The risk model was subsequently validated with GEO31210. By analyzing signaling pathways, immune cells and immune checkpoints using GSEA, GSVA and Cibersortx, the relationship between TEX risk score and these variables was evaluated. In addition, we further analyzed the expression of CCL20 at the level of single-cell RNA-seq and verified it in cell experiments.Results: According to TEX signaling pathway, people with better prognosis can be distinguished. The risk model constructed by CD109, CCL20, DKK1, TNS4, and TRIM29 genes could further accurately identify the population with poor prognosis. Subsequently, it was found that dendritic cells, CD44 and risk score were closely related. The final single-cell sequencing suggested that CCL2O is a potential therapeutic target of TEX, and the interaction between TEX and CD8 + T is closely related.Conclusion: The classification of T cell depletion plays a crucial role in the clinical decision-making of lung adenocarcinoma and needs to be further deepened.
Cerebrovascular reactivity measurements using 3T BOLD MRI and a fixed inhaled CO2 gas challenge: Repeatability and impact of processing strategy
Authors: Sleight Emilie , Stringer Michael S. , Mitchell Isla , Murphy Madeleine , Marshall Ian , Wardlaw Joanna M. , Thrippleton Michael J. 
Published: February 2023

Introduction: Cerebrovascular reactivity (CVR) measurements using blood oxygen level dependent (BOLD) magnetic resonance imaging (MRI) are commonly used to assess the health of cerebral blood vessels, including in patients with cerebrovascular diseases; however, evidence and consensus regarding reliability and optimal processing are lacking. We aimed to assess the repeatability, accuracy and precision of voxel- and region-based CVR measurements at 3 T using a fixed inhaled (FI) CO2 stimulus in a healthy cohort.Methods: We simulated the effect of noise, delay constraints and voxel- versus region-based analysis on CVR parameters. Results were verified in 15 healthy volunteers (28.1±5.5 years, female: 53%) with a test-retest MRI experiment consisting of two CVR scans. CVR magnitude and delay in grey matter (GM) and white matter were computed for both analyses assuming a linear relationship between the BOLD signal and time-shifted end-tidal CO2 (EtCO2) profile.Results: Test-retest repeatability was high [mean (95% CI) inter-scan difference: −0.01 (−0.03, −0.00) %/mmHg for GM CVR magnitude; −0.3 (−1.2,0.6) s for GM CVR delay], but we detected a small systematic reduction in CVR magnitude at scan 2 versus scan 1, accompanied by a greater EtCO2 change [±1.0 (0.4,1.5) mmHg] and lower heart rate [−5.5 (−8.6,−2.4] bpm]. CVR magnitude estimates were higher for voxel- versus region-based analysis [difference in GM: ±0.02 (0.01,0.03) %/mmHg]. Findings were supported by simulation results, predicting a positive bias for voxel-based CVR estimates dependent on temporal contrast-to-noise ratio and delay fitting constraints and an underestimation for region-based CVR estimates.Discussion: BOLD CVR measurements using FI stimulus have good within-day repeatability in healthy volunteers. However, measurements may be influenced by physiological effects and the analysis protocol. Voxel-based analyses should be undertaken with care due to potential for systematic bias; region-based analyses are more reliable in such cases.
Catecholamine concentrations in duck eggs are impacted by hen exposure to heat stress
Authors: Lyte Joshua M. , Lyte Mark , Daniels Karrie M. , Oluwagbenga Esther M. , Fraley Gregory S. 
Published: February 2023

Rapid “fight-or-flight” responses to stress are largely orchestrated by the catecholamines. Moreover, catecholamines and catecholamine precursors are widely recognized to act as interkingdom signaling molecules among host and microbiota, as well as to serve as chemotactic signals for bacterial foodborne pathogens. While albumen and yolk concentrations of glucocorticoids have received extensive attention as non-invasive indicators of hen response to stress, little is known regarding the impact of the hen’s stress response on in ovo catecholamine and catecholamine precursor concentrations. The aim of the present study was to determine norepinephrine and L-dopa concentrations in albumen and yolk of eggs laid by hens maintained under normal or heat stress conditions. Norepinephrine and L-dopa concentrations were also measured in oviductal tissue. Breeder ducks (∼35 weeks/age) were kept under normal (22°C) conditions or subjected to cyclical heat stress (35°C day/29.5°C night) for 3 weeks. Eggs (n = 12 per timepoint/group) were collected on a weekly basis. Hens were sacrificed at baseline or after 3 weeks of heat stress for oviductal tissue collection. Albumen, yolk, and oviduct concentrations of norepinephrine and L-dopa were determined using ultra high-performance liquid chromatography with electrochemical detection. Norepinephrine and L-dopa were detected in oviductal tissue as well as egg albumen and yolk. Norepinephrine concentrations were elevated (p &lt; 0.05) in the yolk of eggs laid by the heat stress group compared to those of the control group. Norepinephrine concentrations in albumen were elevated (p &lt; 0.05) in the heat stress group compared to control group at week 2. L-dopa concentrations were not significantly affected (p &gt; 0.05) by heat stress in albumen, yolk, or oviductal tissue. Together, the present study provides the first evidence of the stress neurohormone, norepinephrine, in duck eggs and identifies that hen exposure to heat stress can affect in ovo norepinephrine concentrations. These data highlight the potential utility of in ovo catecholamine concentrations as non-invasive measures of the hen’s response to stress, as well as warrants future research into whether hen deposition of stress-related neurochemicals into the egg could serve as a chemotactic signal in the vertical transmission of foodborne pathogens.
Patriotism, nationalism, and evaluations of the government’s handling of the coronavirus crisis
Authors: Zhai Yida , Lu Yizhen , Wu Qidi 
Published: February 2023

IntroductionThe COVID-19 pandemic has been accompanied by a global rise of nationalism, and many countries’ responses to the pandemic have further intensified nationalist sentiments. The public is polarized over government policies toward the pandemic. Hence, this study examined the associations of patriotism and nationalism with the support for lockdown policies and evaluations of governmental performance.MethodsWe recruited 180 participants from one Chinese university.ResultsPatriotism and nationalism had a direct effect on evaluations of governmental performance. Patriotism also had indirect effects on favorable evaluations of governmental performance through the support of lockdown policies. In addition, this study examined the relationship of threat perception and evaluations of governmental performance in the pandemic.DiscussionThis relationship was found to be insignificant; however, the interaction effects between threat perception and patriotism on evaluations of governmental performance were significant. The implications of the study results are discussed.
Grandchild care and life satisfaction of older adults: Empirical evidence from China
Authors: Dong Xiangyu , Ling Hongxiang , Yang Tianyi , Wang Kun 
Published: February 2023

BackgroundIn China, grandchild care plays an important social role later in life. The effects of grandchild care on physical health and depression in older adults have been illustrated. However, there is a gap in research on grandchild care and life satisfaction of older adults specifically based on the Chinese experience.MethodBased on 7,079 individuals’ data from 2018 China Longitudinal Aging Social Survey (CLASS), this study explored the impact of grandchild care on older adults’ life satisfaction by using Ordinary Least Squares (OLS), Propensity Score Matching (PSM), and instrumental variables (IV) models.ResultsThe empirical results indicated that (1) life satisfaction was significantly higher for older adults who undertook grandchild care compared to those who did not; (2) non-coresiding grandparents showed higher life satisfaction than those non-carers, and this effect was not found in custodial grandparents or three-generation household grandparents; (3) higher life satisfaction of grandchild caregivers was achieved through reduced loneliness, enhanced self-efficacy, and increased emotional support from children, with the latter being the greatest contribution; and (4) the improving effect of grandchild care on life satisfaction was found mainly in the group of older adults who were male and in rural households.ConclusionThere was a significant difference in life satisfaction between older Chinese adults who provided grandchild care and those who did not. Efforts in terms of old age policy protection and family relationships should be made to enhance the subjective well-being of older adults.
Face-specific negative bias of aesthetic perception in depression: Behavioral and EEG evidence
Authors: Chen Zhitang , Wang Zhenghua , Shen Yuhua , Zeng Suhua , Yang Xiangyu , Kuang Yifang , Dou Zheng , Wang Lihui , Li Weidong 
Published: February 2023

IntroductionSymptoms of depression are associated with the dysfunction of neural systems such as the emotion, reward system, and the default mode network. These systems were suggested by the model of neuroaesthetics as key contributions to aesthetic experience, leading to the prediction of atypical aesthetic orientation in depression. Here we investigated the aesthetic characteristics of depression and the corresponding neural underpinnings.MethodsFifty-two (25 depression patients, 27 healthy controls) participants were asked to make aesthetic judgments on faces and landscapes in an electroencephalographic (EEG) experiment.ResultsOur results indicate that relative to the controls, the depression tended to give ugly judgments and refrained from giving beautiful judgments, which was observed only for faces but not for landscapes. We also found that the face-induced component N170 was more negative in the depression group than the control group for ugly and neutral faces. Moreover, the aesthetic evaluation of ugly faces was associated with decreased N200 negativity in the depression group than in the control group, while the evaluation of beautiful faces was associated with decreased brain synchronization at the theta band.DiscussionThese results suggested a face-specific negative aesthetic bias in depression which can help to design and develop aesthetics-oriented schemes in assisting the clinical diagnosis and therapy of depression.
Primary medical and health preparedness and people's life satisfaction in China: The mediating role of satisfaction with medical and health services
Authors: Tang Zhiwei , Ye Changxiu , Fu Zhuang , Zhang Jingran , Gong Zepeng 
Published: February 2023

ObjectiveTo examine the association between primary medical and health preparedness (PMHP), satisfaction with medical and health services (SMHS), and life satisfaction (LS).MethodsUsing the latest national representative data from the 2019 Chinese Social Survey and the 2018 Health Statistics Yearbook for each province in China, we conducted multi-level models to test the effect of three aspects of PMHP (the number of primary medical and health institutions (PMHIs), the number of beds in PMHIs, and the number of staff in PMHIs) on LS, and the mediation role of SMHS in this effect.ResultsThe number of staff in PMHIs has a significant positive effect on people's LS. Besides, this effect is mediated completely by SMHS. However, the number of PMHIs and the number of beds in PMHIs do not affect LS significantly.ConclusionsPMHP has a positive impact on LS, but this impact is associated only with the number of staff in PMHIs. Therefore, governments should focus on optimizing human resources in PMHIs to meet the LS needs of individuals.
DeepAD: A deep learning application for predicting amyloid standardized uptake value ratio through PET for Alzheimer's prognosis
Authors: Maddury Sucheer , Desai Krish 
Published: February 2023

IntroductionAmyloid deposition is a vital biomarker in the process of Alzheimer's diagnosis. 18F-florbetapir PET scans can provide valuable imaging data to determine cortical amyloid quantities. However, the process is labor and doctor intensive, requiring extremely specialized education and resources that may not be accessible to everyone, making the amyloid calculation process inefficient. Deep learning is a rising tool in Alzheimer's research which could be used to determine amyloid deposition.Materials and methodsUsing data from the Alzheimer's Disease Neuroimaging Initiative, we identified 2,980 patients with PET imaging, clinical, and genetic data. We tested various ResNet, EfficientNet, and RegNet convolutional neural networks and later combined the best performing model with Gradient Boosting Decision Tree algorithms to predict standardized uptake value ratio (SUVR) of amyloid in each patient session. We tried several configurations to find the best model tuning for regression-to-SUVR.ResultsWe found that the RegNet X064 architecture combined with a grid search-tuned Gradient Boosting Decision Tree with 3 axial input slices and clinical and genetic data achieved the lowest loss. Using the mean-absolute-error metric, the loss converged to an MAE of 0.0441, equating to 96.4% accuracy across the 596-patient test set.DiscussionWe showed that this method is more consistent and accessible in comparison to human readers from previous studies, with lower margins of error and substantially faster calculation times. We implemented our deep learning model on to a web application named DeepAD which allows our diagnostic tool to be accessible. DeepAD could be used in hospitals and clinics with resource limitations for amyloid deposition and shows promise for more imaging tasks as well.
Anatomical and Chemical Analysis of Moringa oleifera Stem Tissue Grown under Controlled Conditions
Authors: McVea Holly M. , Wood Lisa J. 
Published: February 2023

Moringa oleifera is a relatively well-studied ethnobotanical species, but information is limited regarding its stem anatomy and the production potential of phytochemicals from bark tissue. Knowing that variation exists in the production of chemical defenses by plants with growing conditions and with developmental stages, M. oleifera was grown under controlled conditions to characterize stem tissues and to determine if stem bark contained the correct phytochemical compounds to be of value in medicinal treatments. We used microscopy to characterize the stem anatomy of M. oleifera and analyzed stem bark extracts using FTIR and GC to identify 4-(α-L-rhamnosyloxy)-benzyl isothiocyanate (moringin) and benzylamine (moringine) in tissue. We found the stems to be in transition between juvenile and mature stages of development at 4 months old under the growth conditions used. In 7-month-old stems, we found the presence of moringin in all bark samples and did not find any moringine. These results indicate that M. oleifera bark of 7-month-old trees grown in greenhouse conditions may be valuable for drug development.
Nickel Chalcogenide Nanoparticles-Assisted Photothermal Solar Driven Membrane Distillation (PSDMD)
Authors: Elmaghraoui Donia , Ben Amara Imen , Jaziri Sihem 
Published: February 2023

Developing photothermal solar driven membrane distillation (PSDMD) is of great importance in providing fresh water for remote off-grid regions. The production of freshwater through the PSDMD is driven by the temperature difference between feed and distillate sides created via the addition of efficient photothermal nanostructures. Here we proposed nickel sulfides and nickel tellurium nanoparticles (NPs) to be loaded into the polymeric membrane to enhance its performance. Ag and CuSe NPs are also considered for comparison as they are previously used for membrane distillation (MD). Our theoretical approach showed that all of the considered NPs increased the temperature of the PVDF membrane by around a few degrees. NiS and NiTe2 NPs are the most efficient solar light-to-heat converters compared to NiTe and NiS2 NPs due to their efficient absorption over the visible range. PVDF membrane loaded with 25% of NiCs NPs and a porosity of 32% produced a transmembrane vapor flux between 22 and 27 L/m2h under a 10-times-amplified sun intensity. Under the same conditions, the PVDF membrane loaded with CuSe and Ag NPs produced 15 and 18 L/m2h of vapor flux, respectively. The implantation of NPs through the membrane not only increased its surface temperature but also possessed a high porosity which provided a higher distillation and energy efficiency that reached 58% with NiS NPs. Finally, great agreement between our theoretical model and experimental measurement is obtained.
Incorporating FRAX into a nurse-delivered integrated care review: a multi-method qualitative study
Authors: Hawarden Ashley , Bullock Laurna , Chew-Graham Carolyn A , Herron Daniel , Hider Samantha , Jinks Clare , Erandie Ediriweera De Silva Risni , Machin Annabelle , Paskins Zoe 
Published: February 2023

BackgroundPeople with inflammatory rheumatological conditions (IRCs) are at increased risk of common comorbidities including osteoporosis.AimTo explore the barriers to and facilitators of implementing nurse-delivered fracture risk assessments in primary care, in the context of multimorbidity reviews for people with IRCs.Design & settingA multi-method qualitative study in primary care.MethodAs part of a process evaluation in a pilot trial, semi-structured interviews were conducted with 20 patients, two nurses, and three GPs. Twenty-four patient–nurse INCLUDE review consultations were audiorecorded and transcribed. A framework analysis was conducted using the Theoretical Domains Framework (TDF).ResultsNurses reported positive views about the value of the Fracture Risk Assessment Tool (FRAX) and they felt confident to deliver the assessments following training. Barriers to implementation, as identified by TDF, particularly related to the domains of knowledge, skills, professional roles, and environmental context. GPs reported difficulty keeping up to date with osteoporosis guidelines and voiced differing opinions about whether fracture risk assessment was the role of primary or secondary care. Lack of integration of FRAX into IT systems was a barrier to use. GPs and nurses had differing views about the nurse role in communicating risk and acting on FRAX findings; for example, explanations of the FRAX result and action needed were limited. Patients reported limited understanding of FRAX outcomes.ConclusionThe findings suggest that, with appropriate training including risk communication, practice nurses are likely to be confident to play a key role in conducting fracture risk assessments, but further work is needed to address the barriers identified.
Combats contre l’essentialisme
Authors: Rosier-Catach Irène 
Published: February 2023

Dans de nombreux travaux, Djamel Kouloughli a défendu une conception résolument antiessentialiste. Dans ses recherches sur Ernest Renan, en particulier dans sa contribution à l’ouvrage Les Grecs, les Arabes et nous, Enquête sur l’islamophobie savante, il a exposé et critiqué les arguments linguistiques visant à opposer les Sémites et les Indo-européens, à partir de prétendues qualités de leurs langues et corrélativement de leurs «schémas mentaux » , qui conduisaient à déprécier les langues du premier groupe, comme impropres à l’expression des savoirs philosophiques et scientifiques, et par là les traductions réalisées et les savoirs produits, notamment durant l’époque abbasside. La superposition indue de critères hétérogènes, linguistiques, religieux, géographiques, politiques, servait à fonder des blocs fondamentalement antagonistes, alors même que les recherches récentes montraient la richesse de tous les mouvements de translatio studiorum
(et linguarum). De façon consonante, Kouloughli cherchait à désessentialiser l’analyse des parlers arabes, pour leur restituer leur spécificité, à la fois historique, géographique et sociolinguistique, refusant qu’ils soient appréciés à partir d’un «gradient » universel, représenté par la grammaire classique, utilisé pour en évaluer la proximité ou la distance.
PERAN KUALITAS AUDIT SEBAGAI PEMODERASI PENGARUH DEWAN KOMISARIS, KOMITE AUDIT DAN UKURAN PERUSAHAAN TERHADAP KINERJA KEUANGAN PERUSAHAAN (Studi pada Bank Umum di BEI, periode 2016-2020)
Authors: Indarti Indarti , Aljufri Aljufri , Apriliyani Ika Berty 
Published: February 2023

Penelitian ini bertujuan untuk menguji adakah pengaruh dewan komisaris, komite audit, dan ukuran perusahaan terhadap kinerja keuangan perusahaan, dengan Kualitas audit sebagai variable moderasi. digunakan sebagai variabel independen. Untuk memperkuat hasil penelitian, pada penelitian ini menggunakan variable moderasi yaitu Kualitas Audit. Kinerja keuangan yang digunakan dalam penelitian ini menggunakan ROA sebagai ukuran dan variabel dependen pada perusahaan perbankan yang terdaftar di Bursa Efek Indonesia. Penelitian ini menggunakan jenis penelitian deskriptif dengan pendekatan kuantitatif, yang diukur dengan menggunakan metode berbasis regresi dengan SPSS 25. Populasi dari penelitian ini adalah perusahaan perbankan yang terdaftar di Bursa Efek Indonesia (BEI) tahun 2016 sampai dengan tahun 2020. Dengan jumlah sampel sebanyak 15 perusahaan perbankan sehingga total observasi dalam penelitian ini sebanyak 75 observasi. Teknik pengumpulan data menggunakan metode dokumentasi melalui situs resmi www.idx.co.id. Hasil Penelitian ini adalah Dewan Komisaris, Komite Audit dan Ukuran Perusahaan berpengaruh terhadap kinerja keuangan. Kualitas Audit mampu memoderasi atau memperkuat pengaruh Komite Audit terhadap Kinerja keuangan pada perushaan perbankan di BEI periode 2016-2020
Fictions potentielles de paysage et de design
Authors: Mathieu Clémence 
Published: February 2023

Dans le cadre d’un projet recherche-création, cet article propose de présenter des méthodes, des outils et une série de premiers travaux qui représentent la diversité des relations humaines et autres qu’humaines autour du fleuve de la Loire. Les méthodes issues du paysagisme et du design permettent de dégager trois temps et échelles d’analyse : l’« horizon de l’être Loire », l’« horizon territorialisé » et l’« horizon des attaches fines ».
Subvertir la reproduction chez Audre Lorde et Donna Haraway
Authors: Pretesacque Chloé 
Published: February 2023

Cet article s’intéresse aux liens entre le concept moderne de nature et la reproduction « du même ». Il s’agit de prendre en compte les stratégies de réarticulation de ces liens effectuées par Audre Lorde et Donna Haraway par l’analyse d’un corpus étroit, composé d’un essai, De l’usage de l’érotisme : l’érotisme comme puissance d’Audre Lorde et d’une science-fiction, les Histoires de Camille de Donna Haraway. Ces autrices proposent des outils stylistiques et épistémologiques capables de proposer des modalités de reproduction alternatives.