bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk assessment model for sleep disturbance based on gastrointestinal myoelectrical activity in middle-aged and elderly people
Authors: Ji Shuming , Li Baichuan , Zhu Chenxing , Jiang Guohui , Tang Yusha , Chen Lei 
Published: June 2023

BackgroundSleep disturbance has become a considerable factor affecting the quality of life for middle-aged and elderly people; however, there are still many obstacles to screening sleep disturbance for those people. Given the growing awareness of the association between gastrointestinal function and sleep disturbance, our study aims to predict the risk of sleep disturbance using gastrointestinal electrophysiological signals.MethodsThe Pittsburgh Sleep Quality Index and gastrointestinal electrophysiological signals of 914 participants in western China were used to establish the model. Demographic characteristics and routine blood test were collected as covariates. Participants were randomly assigned into two sets with a 7:3 ratio for training and validation. In the training set, the least absolute shrinkage and selection operator (LASSO) regression and stepwise logistic regression were used, respectively for variables selection and optimization. To assess the model performance, receiver operator characteristic (ROC) curve, calibration curve and decision curve analysis (DCA) were utilized. Then, validation was performed.ResultsThirteen predictors were chosen from 46 variables by LASSO regression. Then, age, gender, percentage of normal slow wave and electrical spreading rate on the pre-meal gastric channel, dominant power ratio on the post-meal gastric channel, coupling percent and dominant frequency on the post-meal intestinal channel were the seven predictors reserved by logistic regression. The area under ROC curve was 0.65 in the training set and 0.63 in the validation set, both exhibited moderate predictive ability. Furthermore, by overlapping the DCA results of two data-sets, there might be clinical net benefit if 0.35 was used as reference threshold for high risk of sleep disturbance.ConclusionThe model performs a worthy predictive potency for sleep disturbance, which not only provides clinical evidence for the association of gastrointestinal function with sleep disturbance, but also can be considered as an auxiliary assessment for screening sleep disturbance.
Socio-economic inequalities in body mass index among preschool children: do sports programs in early childhood education and care centers make a difference?
Authors: Mayer Alena , Herr Raphael M. , Klein Thomas , Wiedemann Eva , Diehl Katharina , Hoffmann Stephanie , Blume Miriam , Jepsen Dennis , Sundmacher Leonie , Andreas Marike , Schneider Sven 
Published: June 2023

BackgroundOverweight in childhood is considered to be one of the most serious public health challenges. Many studies have investigated individual-level determinants of children's body mass index (BMI), yet studies exploring determinants at the meso-level are sparse. The aim of our study was to examine how a sports focus at early childhood education and care (ECEC) centers moderates the effect of parental socio-economic position (SEP) on children's BMI.MethodsWe used data from the German National Educational Panel Study and included 1,891 children (955 boys and 936 girls) from 224 ECEC centers in our analysis. Linear multilevel regressions were used to estimate the main effects of family SEP and the ECEC center sports focus, as well as their interaction, on children's BMI. All analyses were stratified by sex and adjusted for age, migration background, number of siblings, and employment status of parents.ResultsOur analysis confirmed the wellknown health inequalities in childhood overweight with a social gradient toward a higher BMI for children from lower SEP families. An interactive effect between family SEP and ECEC center sports focus was found. Boys with low family SEP not attending a sports-focused ECEC center had the highest BMI among all boys. In contrast, boys with low family SEP attending a sports-focused ECEC center had the lowest BMI. For girls, no association regarding ECEC center focus or interactive effects emerged. Girls with a high SEP had the lowest BMI, independent of the ECEC center focus.ConclusionWe provided evidence for the gender-specific relevance of sports-focused ECEC centers for the prevention of overweight. Especially boys from low SEP families benefited from a sports focus, whereas for girls the family's SEP was more relevant. As a consequence, gender differences in determinants for BMI at different levels and their interaction should be considered in further research and preventive measures. Our research indicates that ECEC centers may decrease health inequalities by providing opportunities for physical activity.
The implications of socioeconomic factors on salivary bioscience methodological variables in a large pediatric multi-site study
Authors: Mariko Hawa , Uban Kristina A. 
Published: June 2023

IntroductionSalivary bioscience has found increased utilization within pediatric research, given the non-invasive nature of self-collecting saliva for measuring biological markers. With this growth in pediatric utility, more understanding is needed of how social-contextual factors, such as socioeconomic factors or status (SES), influence salivary bioscience in large multi-site studies. Socioeconomic factors have been shown to influence non-salivary analyte levels across childhood and adolescent development. However, less is understood about relationships between these socioeconomic factors and salivary collection methodological variables (e.g., time of saliva collection from waking, time of day of saliva collection, physical activity prior to saliva collection, and caffeine intake prior to saliva collection). Variability in salivary methodological variables between participants may impact the levels of analytes measured in a salivary sample, thus serving as a potential mechanism for non-random systematic biases in analytes.MethodsOur objective is to examine relationships between socioeconomic factors and salivary bioscience methodological variables within the Adolescent Brain Cognitive Development Study© cohort of children aged 9–10 years old (n = 10,567 participants with saliva samples).ResultsWe observed significant associations between household socioeconomic factors (poverty status, education) and salivary collection methodological variables (time since waking, time of day of sampling, physical activity, and caffeine intake). Moreover, lower levels of household poverty and education were significantly associated with more sources of potential bias in salivary collection methodological variables (e.g., longer times since waking, collections later in the day, higher odds of caffeine consumption, and lower odds of physical activity). Consistent associations were not observed with neighborhood socioeconomic factors and salivary methodological variables.DiscussionPrevious literature demonstrates associations between collection methodological variables and measurements of salivary analyte levels, particularly with analytes that are more sensitive to circadian rhythms, pH levels, or rigorous physical activity. Our novel findings suggest that unintended distortions in measured salivary analyte values, potentially resulting from the non-random systematic biases in salivary methodology, need to be intentionally incorporated into analyses and interpretation of results. This is particularly salient for future studies interested in examining underlying mechanisms of childhood socioeconomic health inequities in future analyses.
Systems modelling as an approach for eliciting the mechanisms for hip fracture recovery among older adults in a participatory stakeholder engagement setting
Authors: Ansah John Pastor , Chia Aloysius Wei-Yan , Koh Vanessa Jean Wen , Lai Wei Xuan , Koh Joyce Suang Bee , Goh Kiat Sern , Yeo William , Howe Tet Sen , Seow Dennis Chuen Chai , Mamun Kaysar , Balasubramanian Diraviyam , Varman Surendra Doraiswamy , Yeo Andy Kuei Siong , Elamin Amal , Chan Angelique Wei-Ming , Matchar David Bruce 
Published: June 2023

IntroductionDue to an aging population, the rising prevalence and incidence of hip fractures and the associated health and economic burden present a challenge to healthcare systems worldwide. Studies have shown that a complex interplay of physiological, psychological, and social factors often affects the recovery trajectories of older adults with hip fractures, often complicating the recovery process.MethodsThis research aims to actively engage stakeholders (including doctors, physiotherapists, hip fracture patients, and caregivers) using the systems modeling methodology of Group Model Building (GMB) to elicit the factors that promote or inhibit hip fracture recovery, incorporating a feedback perspective to inform system-wide interventions. Hip fracture stakeholder engagement was facilitated through the Group Model Building approach in a two-half-day workshop of 25 stakeholders. This approach combined different techniques to develop a comprehensive qualitative whole-system view model of the factors that promote or inhibit hip fracture recovery.ResultsA conceptual, qualitative model of the dynamics of hip fracture recovery was developed that draws on stakeholders' personal experiences through a moderated interaction. Stakeholders identified four domains (i.e., expectation formation, rehabilitation, affordability/availability, and resilience building) that play a significant role in the hip fracture recovery journey..DiscussionThe insight that recovery of loss of function due to hip fracture is attributed to (a) the recognition of a gap between pre-fracture physical function and current physical function; and (b) the marshaling of psychological resilience to respond promptly to a physical functional loss via uptake of rehabilitation services is supported by findings and has several policy implications.
Automatic classification of the vertebral endplate lesions in magnetic resonance imaging by deep learning model
Authors: Bassani Tito , Cina Andrea , Galbusera Fabio , Sconfienza Luca Maria , Albano Domenico , Barcellona Federica , Colombini Alessandra , Luca Andrea , Brayda-Bruno Marco 
Published: June 2023

IntroductionA novel classification scheme for endplate lesions, based on T2-weighted images from magnetic resonance imaging (MRI) scan, has been recently introduced and validated. The scheme categorizes intervertebral spaces as “normal,” “wavy/irregular,” “notched,” and “Schmorl's node.” These lesions have been associated with spinal pathologies, including disc degeneration and low back pain. The exploitation of an automatic tool for the detection of the lesions would facilitate clinical practice by reducing the workload and the diagnosis time. The present work exploits a deep learning application based on convolutional neural networks to automatically classify the type of lesion.MethodsT2-weighted MRI scans of the sagittal lumbosacral spine of consecutive patients were retrospectively collected. The middle slice of each scan was manually processed to identify the intervertebral spaces from L1L2 to L5S1, and the corresponding lesion type was labeled. A total of 1,559 gradable discs were obtained, with the following types of distribution: “normal” (567 discs), “wavy/irregular” (485), “notched” (362), and “Schmorl's node” (145). The dataset was divided randomly into a training set and a validation set while preserving the original distribution of lesion types in each set. A pretrained network for image classification was utilized, and fine-tuning was performed using the training set. The retrained net was then applied to the validation set to evaluate the overall accuracy and accuracy for each specific lesion type.ResultsThe overall rate of accuracy was found equal to 88%. The accuracy for the specific lesion type was found as follows: 91% (normal), 82% (wavy/irregular), 93% (notched), and 83% (Schmorl's node).DiscussionThe results indicate that the deep learning approach achieved high accuracy for both overall classification and individual lesion types. In clinical applications, this implementation could be employed as part of an automatic detection tool for pathological conditions characterized by the presence of endplate lesions, such as spinal osteochondrosis.
Is cystourethroscopy a crucial preoperative step in severe and complex types of hypospadias?
Authors: Oshiba Ahmed , Kotb Mostafa 
Published: June 2023

Background and objectivesProximal hypospadias is considered the most severe subtype of the hypospadias spectrum and represents approximately one-fifth of the total cases. It is well-evidenced by many studies that the rate of postoperative complications following the repair of this complex subtype is significantly higher when compared to the distal variants. Few reports described the proximal hypospadias from the other perspective which is the preoperative one. Most pediatric surgeons notice an unexplained incidence of lower urinary tract infection and occasional difficulty of urinary catheterization in those children. This sometimes requires the use of additional measures such as the use of urethral sounds, filiforms and followers, and even catheterization under anesthesia. The aim of the work is to evaluate the role of preoperative cystourethroscopy in detecting associated anomalies in cases of proximal and severe hypospadias.Materials and methodsThis prospective study was conducted in the pediatric surgery unit at Alexandria Faculty of Medicine between July 2020 and December 2021 and included all children with severe grades of hypospadias. After thorough evaluation, all children underwent cystourethroscopy just before the procedure. Any abnormalities in the urethra, urinary bladder, or ureteric openings were recorded if present. Finally, the definitive operation was performed as per schedule.ResultsFifty-two patients (41 fresh and 11 redo patients) with a median (range) age at presentation of 5 (1–16) years were enrolled in this study. The intraoperative cystourethroscopy was done in all of the patients. Significant abnormal findings were recorded in 32 patients (61.5%), while the other 20 patients (38.5%) were revealed to be normal. The most common abnormal findings were dilated prostatic utricle opening and hypertrophied verumontanum (in 23 and 16 cases, respectively).ConclusionAlthough most of the associated anomalies with proximal hypospadias are asymptomatic, cystourethroscopy is better used owing to a high incidence of these anomalies. This can facilitate an early diagnosis as well as early detection and intervention at the time of repair.
Improvement of the method of diagnosis of patients with distal occlusion using extra-oral parameters of a telerentgenogram of the head in a lateral projection
Authors: Danielova B.G. , Persin L.S. , Pankratova N.V. 
Published: June 2023

he aim of the work was to improve the method of diagnosis and treatment of disorders of the dental system in patients with distal occlusion of the dentition, based on the use of extra-oral parameters of the telerentgenogram of the head in a lateral projection.
For a group of patients aged 7—15 years, measurements of 11 angular and 16 linear parameters associated with an extra-facial vertical PLV line were performed. Lateral telerentgenograms of the head of patients of appropriate age from the archive of the Department of Orthodontics of the Moscow State Medical University named after A.I. Evdokimov were used as control group data.
The analysis made it possible to identify parameters whose values have significant differences from the values of the corresponding parameters of groups of patients with physiological occlusion, which can be used in practical work.
The use of the combined anesthesia method using local anesthesia and percutaneous electroneurostimulation for dental implantation
Authors: Yudin D.K. , Mozgovoy V.V. , Dragunova S.G. , Kosyreva T.F. , Kastyro I.V. , Gette S.A. 
Published: June 2023

The purpose of the work: to conduct a comparative assessment of the adequacy of pain relief based on the study of the dynamics of pain indicators, the autonomic nervous system and the psycho-emotional status of patients with a combination of local anesthesia and percutaneous electroneurostimulation.
Materials and methods. 40 patients aged 38 to 63 years took part in the study. The number of patients in the first group amounted to 20 people aged 38 to 63 years, and they all completed the study. In the first group, only local anesthesia (MA) was used by a 4% solution of articaine with epinephrine in a concentration of 1: 200000. In the second group, the number of patients was 20 people aged 38 to 60 years, and all of them also completed the study. In the second group — a combination of percutaneous electroneurostimulation (Chens) with subsequent local anesthesia (Chens+Ma); Electroneurostimulation was carried out using the EPB50-01 Electronics device (Russia), which generates bipolar asymmetric current pulses of 20 s and a frequency of 10 imp/s. The intensity of electroneurostimulation was selected individually until the patient achieve intense non -pain sensations.
Results. The use of percutaneous electroneurostimulation potentiates the analgesic effect of local anesthesia in the intraoperative period and has a prolonged analgesic effect, which manifests itself in a decrease in the intensity of pain throughout the postoperative period. Analysis of the features of the action of percutaneous electroneurostimulation indicates that this effect is due to exacerbation of not pain sensitivity, but by sensitization (exacerbation of sensitivity) of non -column peripheral nerves and oral trigeminal core, transmitting signals from receptors that are excited with no damaging effects (touches, displacement of tissues). This sensitization can develop as a result of prolonged preliminary electroneurostimulation, which was carried out before the injection. Against the background of sensitization of sensation from any mechanical effects on the tissue, more acute will be perceived, which was evaluated by patients as more intense pain. This feature of the action of percutaneous electroneurostimulation must be taken into account when compiling methods of its application in clinical practice.
Conclusion. The use of percutaneous electroneurostimulation creates favorable conditions for the period of adaptation and integration of implants in the early stages of the postoperative period.
Pengaruh Perilaku Konsumen Dalam Membeli Sayur Hidroponik Non Pestisida Di Kota Padang
Authors: Leovita Angelia , Rangkuti Irfan , Dermawan Alvindo 
Published: June 2023

Sektor pertanian adalah salah satu sektor penyumbang pendapatan dalam pembangunan Indonesia. Sektor pertanian yang menopang kebutuhan manusia juga menyumbang dampak negatif dalam rusaknya, diantaranya yaitu revolusi hijau. Tujuan dalam penelitian ini adalah menganalisis pengaruh perilaku konsumen dalam pengambilan keputusan pembelian sayur hidroponik non pestisida di Kota Padang. Metode pengambilan sampel yaitu non probability sampling dengan metode sampling incidental, sampel yang diambil sebanyak 40 responden. Hasil dalam penelitian berdasarkan analisis regresi linear bahwa faktor kebudayaan, faktor sosial tidak berpengaruh signifikan dalam pengambilan keputusan pembelian sayur hidroponik non pestisida di kota Padang, sedangkan faktor pribadi, faktor psikologi berpengaruh signifikan dalam pengambilan keputusan pembelian sayur hidroponik non pestisida di Kota Padang
Nilai Tambah Produk Agroindustri Keripik di Kota Kefamenanu (Studi Kasus Usaha Keripik Paman Sularso)
Authors: Joka Umbu 
Published: June 2023

Abstrak

Penelitian tentang usaha keripik bertujuan untuk mengetahui besar nilai tambah dari pengolahan usaha keripik (Pisang dan Ubi kayu) di Kota Kefamenanu. Metode analisis data yang digunakan dalam penelitian ini adalah metode analisis deskriptif kualitatif, dan analisis nilai tambah. Sampelnya adalah pemilik usaha sendiri yaitu Paman Sularso. Hasil penelitian menunjukkan bahwa Usaha Keripik (pisang dan ubi) pada tahun 2021. Nilai tambah yang diperoleh dari pengolahan keripik ubi dalam satu tahun adalah Rp 3.600. Nilai tambah ini diperoleh dari pengurangan nilai produk dengan harga bahan baku dan nilai input lain. Rasio nilai tambah merupakan perbandingan antara nilai tambah dengan nilai produk. Rasio nilai tambah yang diperoleh adalah 14,0625 persen. Hal ini berarti dalam pengolahan pisang dan ubi menjadi keripik memberikan nilai tambah sebesar 14,0625 persen dari nilai produk Nilai tambah yang diperoleh dari pengolahan keripik pisang dalam satu adalah Rp 5.077. Nilai tambah ini diperoleh dari pengurangan nilai produk dengan harga bahan baku dan nilai input lain. Rasio nilai tambah merupakan perbandingan antara nilai tambah dengan nilai produk. Rasio nilai tambah yang diperoleh adalah 22 persen.

Keywords:, Agroindustri, Keripik, Nilai tambah
Penggunaan Metode Mind Maping Dalam Pembelajaran Menulis Teks Drama
Authors: Marisya Susanti , Chairani Zuraida 
Published: June 2023

Penelitian ini dilatarbelakangi oleh kesulitan siswa dalam pembelajaran menulis teks drama. Siswa lebih menyukai untuk bermain peran dari naskah yang telah ada daripada menulis teks drama. Hal ini lah yang menjadikan pembelajaran menulis teks drama kurang diminati oleh siswa. Siswa juga kurang mampu dalam menyusun ide/ gagasan dalam bentuk tulisan secara sistematis. Banyak dari tulisan mereka yang tidak efektif dan berbelit-belit dari segi alur ceritanya. Beberapa penelitian lain juga menunjukkan bahwa menulis teks drama sulit dan mengalami beberapa kendala. Seperti penelitian yang dilakukan oleh Kusumawati, dkk (2016) dalam Jurnal pendidikan bahasa dan sastra Indonesia. penelitian tesebut menyatakan bahwa pembelajaran menulis teks drama mengalami beberapa kendala baik dari faktor siswa maupun guru. Penelitian ini merupakan penelitian kuantitatif deskriptif. Penarikan sampel dilakukan dengan tenik random sampling dengan jumlah 19 sampel. Data dianalisis dengan Pertama, memeriksa hasil kerja siswa sesuai dengan rubrik penilaian menulis teks drama. kedua, menentukan skor menulis teks drama. Ketiga, mengubah skor menjadi nilai. Keempat, menentukan nilai rata-rata hitung. Kelima, mendeskripsikan kemampuan menulis teks drama. Keenam, memberikan kesimpulan. Hasil penelitian menunjukkan bahwa kemampuan siswa dalam menulis teks drama dengan menggunakan metode mind maping memperoleh nilai rata-rata 80,70. Berada pada rentang 76-85% dengan kualifikasi baik. Penggunaan mind maping terbukti efektif dan inovatif dalam pembelajaran menulis teks drama.
Evaluation of Neuroprotective Activity of Chrysin Nanoparticles Using Scopalamine Induced Neuroinflammation in the Rat Model of Alzheimer’s Disease
Authors: Karthik Sirigiri Venkat , V Chinnikrishnaiah , S Sudhakar 
Published: June 2023

Background: scopolamine induced neuroinflammation limits its long-term clinical use. Several agents/strategies were attempted to prevent scopolamine neuroinflammatory but were not found suitable for clinical use.
Objective: To investigate the neuroprotective activity of chrysin nanoparticle on scopolamine induced neuroinflammation.
Material and Method: Male Albino wistarrats (180- 230 grms) were evenly divided into 5 groups. Group I&II served as control (distilled water 10ml/kg) and diseases control (scopolamine) 100mg/kg per os treated for 4 weeks, group III served as standard group which received Donepezil (1.5mg/kg) on ,while group IV and V are simultaneously treated with (50mg/kg and 100 mg/kg) orally with chrysin nanoparticle up to 4 weeks. On 29 and 30 day behavioral parameters and brain were isolated for biochemical parameters at the same time rat brains were used for histological studies.
Results: Treatment of scopolamine caused neuroinflammation as the evidence by marked elevation in AchE, GSH, catalase, super oxide Dismutase, Elevated plus maze,Y-maze and Open field test. SLN chrysin decrease in AchE, catalase, super oxide dismutase, GSH time respectively. SLN chrysin increase activities of SOD, crossing, Rearing, Grooming. Histopathological changes also showed the protective nature SLN chrysin induced neuroinflammation