bluuebunny/crossref_metadata_2025_split huggingface dataset:
When do I ponder? The role of elaboration in counterfactual thinking
Authors: Sivaraman Anuradha , Ford Weixing , Sundaram Suresh 
Published: July 2023

AbstractThe counterfactual thought such as “If only I had…” has a powerful impact on people's subsequent behavioral intentions. The literature has documented what may happen with CFT. But little has been done to investigate how CFT produces these effects. In this research, three studies provided evidence to show that elaboration rather than priming is the mechanism for CFT to have an effect on behavioral intentions; and the factors such as argument strength, outcome severity, and goal valence may interfere with such counterfactual effects. These theoretical contributions to the CFT literature offer important managerial implications and help marketers determine optimal persuasion strategies to influence consumers' information processing style.
ent‐Kaurane‐Type Diterpenes Induce ROS‐Mediated Mitochondrial Dysfunction and Apoptosis by Suppress the Homologous Recombination DNA Repair in Triple‐Negative Breast Cancer Cells
Authors: Xie Yikun , Su Yifan , Liao Zirou , Liang Xinran , Hua Jing , Zhang Dawei , Hu Dexuan , Yu Qian 
Published: July 2023

AbstractSix ent‐kaurane‐type diterpenes were isolated from the roots of Isodon ternifolia. Previous studies have shown that compounds 1 and 2 exhibited cytotoxicity against three human cancer cell lines (MCF‐7, A549, and HCT116), but its molecular mechanism has not been studied yet. In the present study, the inhibited proliferation of compounds 1 and 2 of two triple‐negative breast cancer (TNBC) cell lines (4T1 and MDA‐MB‐231) have been demonstrated by MTT and colony formation assay. Flow cytometry, western blotting, and qPCR were used to further demonstrate the apoptosis process in TNBCs. Importantly, the following mitochondrial membrane potential (MMP) decrease during apoptosis was demonstrated to correlate to reactive oxygen species (ROS) production. In addition, DNA damage induced by compounds 1 and 2 was illustrated by detect of homologous recombination (HR) DNA repair genes and proteins expression, such as RAD51. These results indicated that compounds 1 and 2 could trigger the TNBCs apoptosis mediated by ROS‐induced mitochondrial dysfunction and induce DNA double‐strand breaks (DSBs) by down regulating HR DNA repair. Furthermore, this research reveals that the mechanism between mitochondria dysfunction and DNA damage is deserved to be investigated for elucidating the dynamic signal transduction between the nucleus and the cellular matrix during apoptosis.
Highly Efficient Electrochemiluminescence from Imidazole‐Based Thermally Activated Delayed Fluorescence Emitters
Authors: Pavan Giulio , Morgan Luca , Demitri Nicola , Alberoni Chiara , Scattolin Thomas , Aliprandi Alessandro 
Published: July 2023

AbstractA family of novel thermally activated delayed fluorescence (TADF) emitters has been synthesized by a straightforward and metal‐free synthesis, and structurally characterized. In this work we kept the acceptor moiety, 4‐(1H‐imidazol‐1‐yl)benzonitrile, fixed and systemically tested different donors to correlate their photophysical and electrochemical properties with their performance in electrochemiluminescence using both benzoyl peroxide as co‐reactant and co‐reactant free (annihilation) conditions. Some compounds exceeded the efficiency of the standard [Ru(bpy)3]Cl2 by up to 28 times with benzoyl peroxide and 38 times in annihilation. Interestingly, we found that the efficiency is mainly dictated by the electrochemical reversibility of the redox processes rather than by the photophysical properties in terms of photoluminescence quantum yields or excited‐state lifetime. In addition, the annihilation electrochemiluminescence efficiency strongly depends on the pulse sequence. The imidazole moiety can be conveniently alkylated, thus allowing the insertion of functional groups, such a carboxylic acid, and enabling practical applications.
Combination of deep learning and ensemble machine learning using intraoperative video images strongly predicts recovery of urinary continence after robot‐assisted radical prostatectomy
Authors: Nakamura Wataru , Sumitomo Makoto , Zennami Kenji , Takenaka Masashi , Ichino Manabu , Takahara Kiyoshi , Teramoto Atsushi , Shiroki Ryoichi 
Published: July 2023

AbstractBackgroundWe recently reported the importance of deep learning (DL) of pelvic magnetic resonance imaging in predicting the degree of urinary incontinence (UI) following robot‐assisted radical prostatectomy (RARP). However, our results were limited because the prediction accuracy was approximately 70%.AimTo develop a more precise prediction model that can inform patients about UI recovery post‐RARP surgery using a DL model based on intraoperative video images.Methods and ResultsThe study cohort comprised of 101 patients with localized prostate cancer undergoing RARP. Three snapshots from intraoperative video recordings showing the pelvic cavity (prior to bladder neck incision, immediately following prostate removal, and after vesicourethral anastomosis) were evaluated, including pre‐ and intraoperative parameters. We evaluated the DL model plus simple or ensemble machine learning (ML), and the area under the receiver operating characteristic curve (AUC) was analyzed through sensitivity and specificity. Of 101, 64 and 37 patients demonstrated “early continence (using 0 or 1 safety pad at 3 months post‐RARP)” and “late continence (others),” respectively, at 3 months postoperatively. The combination of DL and simple ML using intraoperative video snapshots with clinicopathological parameters had a notably high performance (AUC, 0.683–0.749) to predict early recovery from UI after surgery. Furthermore, combining DL with ensemble artificial neural network using intraoperative video snapshots had the highest performance (AUC, 0.882; sensitivity, 92.2%; specificity, 78.4%; overall accuracy, 85.3%) to predict early recovery from post‐RARP incontinence, with similar results by internal validation. The addition of clinicopathological parameters showed no additive effects for each analysis using DL, EL and simple ML.ConclusionOur findings suggest that the DL algorithm with intraoperative video imaging is a reliable method for informing patients about the severity of their recovery from UI after RARP, although it is not clear if our methods are reproducible for predicting long‐term UI and pad‐free continence.
Short‐time existence for the network flow
Authors: Lira Jorge , Mazzeo Rafe , Pluda Alessandra , Sáez Mariel 
Published: July 2023

AbstractThis paper contains a new proof of the short‐time existence for the flow by curvature of a network of curves in the plane. Appearing initially in metallurgy and as a model for the evolution of grain boundaries, this flow was later treated by Brakke using varifold methods. There is good reason to treat this problem by a direct PDE approach, but doing so requires one to deal with the singular nature of the PDE at the vertices of the network. This was handled in cases of increasing generality by Bronsard‐Reitich, Mantegazza‐Novaga‐Tortorelli and eventually, in the most general case of irregular networks by Ilmanen‐Neves‐Schulze. Although the present paper proves a result similar to the one in Ilmanen et al., the method here provides substantially more detailed information about how an irregular network “resolves” into a regular one. Either approach relies on the existence of self‐similar expanding solutions found in Mazzeo and Saez. As a precursor to the main theorem, we also prove an unexpected regularity result for the mixed Cauchy‐Dirichlet boundary problem for the linear heat equation on a manifold with boundary.
Pharmacokinetics, Safety, and Tolerability of Vonoprazan‐ or Esomeprazole‐Based Bismuth‐Containing Quadruple Therapy: A Phase 1, Double‐Blind, Parallel‐Group Study in Adults with Helicobacter pylori Infection in China
Authors: Miao Jia , Hu Chao , Tang Jie , Wang Wenyan , Wang Ying , Men Ruoting , Yang Li , Gu Liqun , Yoshida Naoki , Czerniak Richard 
Published: July 2023

AbstractQuadruple therapy comprising 2 antibiotics, a proton pump inhibitor, and bismuth, is recommended for Helicobacter pylori eradication in China. This Phase 1, double‐blind, parallel‐group study aimed to evaluate the pharmacokinetics, safety, and tolerability of bismuth‐containing vonoprazan‐ or esomeprazole‐based quadruple therapy in H. pylori–positive healthy subjects at a single site in China. Quadruple therapy comprising vonoprazan 20 mg or esomeprazole 20 mg with bismuth potassium citrate 600 mg (equivalent to bismuth 220 mg), clarithromycin 500 mg, and amoxicillin 1000 mg was administered twice daily for 2 weeks. Forty‐four subjects were enrolled, 22 each in the vonoprazan (mean age, 34.5 years; men, 63.6%) and esomeprazole (mean age, 31.6 years; men, 59.1%) groups. Day 14 bismuth plasma pharmacokinetic parameters area under the plasma concentration–time curve during a dosing interval (geometric mean ratio, 1.07 [90% confidence interval, 0.82–1.40]) and maximum observed plasma concentration (geometric mean ratio, 1.30 [90% confidence interval, 0.94–1.81]) were similar between the treatment groups. At Day 42 follow‐up, 100% and 94.4% of subjects were H. pylori negative in the vonoprazan and esomeprazole groups, respectively. The incidence of treatment‐emergent adverse events was similar between the groups, with no serious adverse events. No new safety concerns were identified. In conclusion, vonoprazan had no significant effect on plasma bismuth exposure compared with esomeprazole.
Pharmacokinetics of the Akt Serine/Threonine Protein Kinase Inhibitor, Capivasertib, Administered to Healthy Volunteers in the Presence and Absence of the CYP3A4 Inhibitor Itraconazole
Authors: Miller Claire , Sommavilla Roberto , Barry Simon T. , Eberlein Cath , Morris Thomas , Wadsworth Ian , Cullberg Marie 
Published: July 2023

AbstractCapivasertib is a potent, selective inhibitor of all 3 Akt isoforms (Akt1/2/3), and it is currently being tested in Phase III trials for the treatment of prostate and breast cancer. To investigate the effect of a cytochrome P450 3A4 (CYP3A4) inhibitor on the pharmacokinetics of capivasertib, a Phase I drug–drug interaction study of capivasertib and itraconazole was conducted in 11 healthy volunteers (median age, 54 years). The 8‐day study had 3 stages: Participants received a single dose of capivasertib 80 mg in Stage 1, 4 doses of itraconazole 200 mg over 3 days in Stage 2, and a final dose of capivasertib 80 mg coadministered with itraconazole 200 mg in Stage 3. Capivasertib pharmacokinetics were examined in Stages 1 and 3. Itraconazole coadministration increased the maximum plasma concentration of capivasertib and total capivasertib exposure (area under the concentration–time curve from time of administration to infinity) by 1.70‐fold (90% confidence interval, 1.56–1.86) and 1.95‐fold (90% confidence interval, 1.82–2.10), respectively.
Can I count on you? Social support, depression and suicide risk
Authors: Silva Christiana , McGovern Christopher , Gomez Stephanie , Beale Eleanor , Overholser James , Ridley Josephine 
Published: July 2023

AbstractObjectivesInterpersonal factors play an important role in the etiology and treatment of depression. Social support derives from compassionate words and helpful actions provided by family, friends or a significant other. The present study was designed to examine various sources of social support as they relate to the severity of depressive symptoms, hopelessness and suicide risk in adult psychiatric outpatients.MethodParticipants were recruited through mental health clinics at a veteran's affairs medical centre. A total of 96 depressed patients were assessed using a diagnostic interview and self‐report measures of depression severity, hopelessness and social support. Among these depressed adults, 45.8% had attempted suicide at least once. Social support variables were compared between suicide attempters and non‐attempters to better understand the relationship between social support and suicidal behaviour.ResultsDepression severity and hopelessness were both significantly associated with lower levels of social support in multiple areas. Individuals with a history of suicide attempt reported lower levels of available support as compared to those who have never attempted suicide.ConclusionDeficient social relationships increase the risk of suicide in depressed patients, exceeding the impact of depression alone on suicide risk. The lack of social support may play a vital role in feelings of hopelessness and isolation that contribute to a suicidal crisis. Psychosocial treatment should be considered to reduce the risk of suicide and severity of depression by strengthening social support and bolstering interpersonal relationships.
Allogeneic haematopoietic cell transplants as dynamical systems: influence of early‐term immune milieu on long‐term T‐cell recovery
Authors: Zelikson Viktoriya , Sabo Roy , Serrano Myrna , Aqeel Younus , Ward Savannah , Al Juhaishi Taha , Aziz May , Krieger Elizabeth , Simmons Gary , Roberts Catherine , Reed Jason , Buck Gregory , Toor Amir 
Published: July 2023

AbstractObjectivesImmune recovery following haematopoietic cell transplantation (HCT) functions as a dynamical system. Reducing the duration of intense immune suppression and augmenting antigen presentation has the potential to optimise T‐cell reconstitution, potentially influencing long‐term outcomes.MethodsBased on donor‐derived T‐cell recovery, 26 patients were adaptively randomised between mycophenolate mofetil (MMF) administered for 30‐day post‐transplant with filgrastim for cytokine support (MMF30 arm, N = 11), or MMF given for 15 days with sargramostim (MMF15 arm, N = 15). All patients underwent in vivo T‐cell depletion with 5.1 mg kg−1 antithymocyte globulin (administered over 3 days, Day −9 through to Day −7) and received reduced intensity 450 cGy total body irradiation (3 fractions on Day −1 and Day 0). Patients underwent HLA‐matched related and unrelated donor haematopoietic cell transplantation (HCT).ResultsClinical outcomes were equivalent between the two groups. The MMF15 arm demonstrated superior T‐cell, as well as T‐cell subset recovery and a trend towards superior T‐cell receptor (TCR) diversity in the first month with this difference persisting through the first year. T‐cell repertoire recovery was more rapid and sustained, as well as more diverse in the MMF15 arm.ConclusionThe long‐term superior immune recovery in the MMF15 arm, administered GMCSF, is consistent with a disproportionate impact of early interventions in HCT. Modifying the ‘immune‐milieu’ following allogeneic HCT is feasible and may influence long‐term T‐cell recovery.
Endoscopic ultrasound‐guided hepaticogastrostomy versus choledochoduodenostomy for malignant biliary obstruction: A meta‐analysis
Authors: Yamazaki Hirofumi , Yamashita Yasunobu , Shimokawa Toshio , Minaga Kosuke , Ogura Takeshi , Kitano Masayuki 
Published: July 2023

AbstractObjectivesEndoscopic ultrasound (EUS)‐guided biliary drainage encompasses techniques such as EUS‐guided hepaticogastrostomy (EUS‐HGS) and EUS‐guided choledochoduodenostomy (EUS‐CDS). This meta‐analysis compared the efficacy of EUS‐CDS with that of EUS‐HGS for the treatment of biliary obstruction.MethodsA systematic meta‐analysis of all relevant articles listed was performed by searching the Cochrane Library, PubMed, and Google Scholar databases. We used random effects or fixed effects models to compare success rates, adverse events, procedure times, and time to recurrent biliary obstruction after EUS‐CDS and EUS‐HGS.ResultsThis meta‐analysis included 18 eligible studies. There was no significant difference between EUS‐CDS and EUS‐HGS with respect to technical success rate (odds ratio [OR] 1.04; 95% confidence interval [CI] 0.62–1.73) and clinical success rate (OR 0.66; 95% CI 0.43–1.04), or with respect to total procedure‐related adverse events (OR 1.39; 95% CI 1.00–1.93). Subgroup analysis of adverse events revealed that the rate of recurrent biliary obstruction (RBO) was significantly higher for EUS‐HGS (OR 2.95; 95% CI 1.54–5.64). There was no significant difference between the two methods with respect to time to recurrent biliary obstruction (mean difference –11.93 days; 95% CI –47.77–23.91). However, the procedure time was longer for EUS‐HGS (mean difference, 3.21 min; 95% CI 1.24–5.19).ConclusionEUS‐CDS and EUS‐HGS are comparable in terms of technical success, clinical success, and rate of adverse events; however, EUS‐CDS is superior with respect to procedure time and preventing RBO.
Radiation therapy for low‐ and high‐risk perineural invasion in head and neck cutaneous squamous cell carcinoma: Clinical outcomes and patterns of failure
Authors: Gobillot Theodore A. , Greer Matthew , Parvathaneni Upendra , Liao Jay J. , Laramore George E. , Goff Peter , Wallner Kent , Rodriguez Cristina P. , Houlton Jeffrey J. , Barber Brittany R. , Futran Neal D. , Rizvi Zain H. 
Published: July 2023

AbstractBackgroundPerineural invasion (PNI) in head and neck squamous cell carcinoma (HNSCC) portends poor prognosis. Extent of treatment of nerve pathways with varying degrees of PNI and patterns of failure following elective neural radiotherapy (RT) remain unclear.MethodsRetrospective review of HNSCC patients with high‐risk (clinical/gross, large‐nerve, extensive) or low‐risk (microscopic/focal) PNI who underwent curative‐intent treatment from 2010 to 2021.ResultsForty‐four patients (mean follow‐up 22 months; 59% high‐risk, 41% low‐risk PNI) were included. Recurrence following definitive treatment occurred in 31% high‐risk and 17% low‐risk PNI patients. Among high‐risk patients, 69% underwent surgery with post‐operative RT and 46% underwent elective neural RT. Local control (83% low‐risk vs. 75% high‐risk), disease‐free, and overall survival did not differ between groups.ConclusionsHigh local control rates were achieved in high‐risk PNI patients treated with adjuvant or primary RT, including treatment of both involved and uninvolved, communicating cranial nerves, with few failures in electively treated regions.
Feasibility of omitting contralateral neck irradiation in patients with node‐negative sinonasal squamous cell carcinoma crossing the midline
Authors: Liu Qian , Lun Lixin , Sun Meng , Wang Zekun , Qu Yuan , Huang Xiaodong , Chen Xuesong , Wang Jingbo , Zhang Jianghu , Wang Kai , Wu Runye , Zhang Ye , Yi Junlin , Luo Jingwei 
Published: July 2023

AbstractBackgroundIdentifying the lymph node target volume in patients with node‐negative sinonasal squamous cell carcinoma (SNSCC) crossing the midline poses a challenge. This study aims to address this.MethodsWe retrospectively reviewed clinically N0 patients with tumors crossing the midline who received elective neck irradiation (ENI) from two centers between 1999 and 2019. The main endpoint was regional relapse‐free survival (RRFS).ResultsWe included 104 patients: 64 received bilateral ENI, and 40 received ipsilateral‐only ENI (median follow‐up time was 89.99 and 95.01 months, respectively). At 5 years, the RRFS rates were comparable (57.68% vs. 55.83%, p = 0.372), as were the contralateral RRFS (57.68% vs. 61.62%, p = 0.541). Five‐year OS, LRFS, and DMFS showed no significant difference between two groups.ConclusionsOur findings provide preliminary evidence suggesting the potential for avoiding contralateral ENI in SNSCC patients with midline crossing tumors who undergo ipsilateral ENI, covering at least level II. Validation through future prospective studies is necessary.
Nurses’ assessment of health literacy requirements for adult inpatients: An integrative review
Authors: Hogan Alana , Hughes Lynda , Coyne Elisabeth 
Published: July 2023

AbstractIssue AddressedThis paper reviews current research which examines nurses' assessment of patient's health literacy in the acute hospital setting. Research highlights, that patients with low health literacy have more frequent hospitalisations and are more likely to be re‐admitted. Within the healthcare team, nurses are primarily responsible for teaching patients and deciphering health communication, to enhance understanding. Within the acute care setting, there remains a disparity in patient understanding of information, despite nurse‐led education. The health literacy assessment and tailoring of information by nurses, is becoming more important with shorter stays, plus limited family visits and the wearing of masks with COVID‐19 related changes.MethodsAn integrative review across four nursing databases, from 2010 and June 2022 was conducted. The integrative framework included problem identification, literature search, data evaluation, data analysis with thematic analysis, and results presentation.ResultsNine studies were included. Common themes were nurses' overestimation of patients' health literacy, the use of universal precautions, and adapting communication techniques to improve education moments.ConclusionThe findings of this review indicate a tendency among nurses to overestimate their patients' health literacy levels, which can result in ineffective health education and inadequate discharge planning.So WhatNurses decipher health communication for their patients. Designing tailored patient communication and education could potentially be a cost saving measure for hospitals by reducing length of stay and reducing readmissions. Health literacy training should be incorporated into nursing practice.
A prognostic biomarker NRG1 promotes U‑87 MG glioblastoma cell malignancy by inhibiting autophagy via ERBB2/AKT/mTOR pathway
Authors: Lin Jia‐zhe , Lin Nuan , Zhao Wei‐Jiang 
Published: July 2023

AbstractGlioblastoma (GBM) is the most common and aggressive primary brain malignancy. Studies have shown that autophagy‐related (ATG) genes play important roles in regulating GBM malignancy. However, the mechanism still needs to be fully elucidated. Based on clinical and gene expression information of GBM patients downloaded from The The Cancer Genome Atlas database, Kaplan–Meier, univariate Cox regression, least absolute shrinkage and selection operator regression and multivariate Cox regression were applied to construct a risk signature for GBM prognosis, followed by validation using receiver operating characteristic analysis. Next, Cell Counting Kit‐8, wound healing assay, flow cytometry, monodansyl cadaverine autophagy staining assay, immunofluorescence staining and western blot, either in the absence or presence of ERBB2/AKT/mTOR inhibitors, were carried out in GBM U87 cell line to explore molecular pathway underlying GBM malignancy. A three‐ATG‐gene signature (HIF1A, ITGA3, and NGR1) was constructed for GBM prognosis with the greatest contribution from NRG1. In vitro experiments showed that NRG1 promoted U87 cell migration and proliferation by inhibiting autophagy, and ERBB2/AKT/mTOR is a downstream pathway that mediates the autophagy‐inhibitory effects of NRG1. We constructed an ATG gene prognostic model for GBM and demonstrated that NRG1 inhibited autophagy by activating ERBB2/AKT/mTOR, promoting GBM malignancy, thus providing new insights into the molecular contribution of autophagy in GBM malignancy.