bluuebunny/crossref_metadata_2025_split huggingface dataset:
POWER Up—Improving pre-exposure prophylaxis (PrEP) uptake among Black cisgender women in the Southern United States: Protocol for a stepped-wedge cluster randomized trial (SW-CRT)
Authors: Ridgway Jessica P. , Devlin Samantha A. , Friedman Eleanor E. , Enaholo Ososese E. , Pyra Maria , Hirschhorn Lisa R. , Haider Sadia , Ducheny Kelly , Johnson Amy K. 
Published: May 2023

BackgroundHIV disproportionately affects Black/African American cisgender women (hereafter women) in the United States. Despite its proven effectiveness, pre-exposure prophylaxis (PrEP) for HIV prevention remains vastly under-prescribed to women based on their need. Increasing PrEP uptake and persistence among women is crucial to reducing HIV transmission; however, there have been few studies designed specifically for women. This article describes the study protocol used to assess the feasibility, acceptability, and effectiveness of implementation strategies to improve PrEP uptake and persistence among Black women in the Midwest and South.MethodsPrEPOptimization amongWomen toEnhanceRetention andUptake (POWER Up) is an evidence-based, woman-focused set of five implementation science strategies that addresses barriers of PrEP utilization at the provider, patient, and clinic levels. POWER Up includes 1) routine PrEP education for patients, 2) standardized provider training, 3) electronic medical record (EMR) optimization, 4) PrEP navigation, and 5) PrEP clinical champions. These strategies will be adapted to specific clinics for implementation, tested via a stepped-wedge trial, and, if effective, packaged for further dissemination.DiscussionWe will utilize a stepped-wedge cluster randomized trial (SW-CRT) to measure change in PrEP utilization across diverse geographic areas. Preparation for adapting and implementing the bundle of strategies is needed to determine how to tailor them to specific clinics. Implementation challenges will include adapting strategies with the available resources at each site, maintaining stakeholder involvement and staff buy-in, adjusting the study protocol and planned procedures as needed, and ensuring minimal crossover. Additionally, strengths and limitations of each strategy must be examined before, during, and after the adaptation and implementation processes. Finally, the implementation outcomes of the strategies must be evaluated to determine the real-world success of the strategies. This study is an important step toward addressing the inequity in PrEP service delivery and increasing PrEP utilization among Black women in the U.S.
QUANTITATIVE DETERMINATION OF THE SUM OF FLAVONOIDS OF THE ABOVEGROUND PART OF SCUTELLARIA COMOSA
Authors: Mamatkhanova Munirakhon Akhmathon kizi , Ergasheva Shohida Abdukodir kizi , Botirov Erkin Khozhiakbarovich , Mulyukin Maksim Aleksandrovich , Khalilov Ravshanjon Muratjanovich , Mamatkhanov Akhmatkhon Umarkhanovich 
Published: May 2023

As a result of pharmacological studies, it was revealed that the sum of flavonoids from the aboveground part of the plant Scutellaria comosa (Lamiaceae family) has adaptogenic and antihypoxic effects. For the introduction into medical practice of a drug based on the sum of flavonoids, studies have been conducted on the standardization of raw materials – the aboveground part of the crested helmet. The analysis of plant raw materials by TLC and HPLC methods showed that the dominant flavonoid of the aboveground part of the crested skullcap is isoscutellarein 7-O-β-D-glucopyranoside.
A differential spectrophotometric technique has been developed for the quantitative determination of the sum of flavonoids of the aboveground part of the crested helmet in terms of isoscutellarein 7-O-β-D-glucopyranoside. The optimal parameters for the extraction of vegetable raw materials are: extraction with 70% ethyl alcohol in a boiling water bath for 60 minutes in the ratio "raw material – extractant" – 1 : 100, the degree of grinding of raw materials – 2 mm. It was found that with the differential version of spectrophotometric analysis, the flavonoids – AlCl3 system reaches equilibrium after 40 minutes. The maximum of the differential absorption spectrum of the alcohol extraction of Scutellaria comosa is observed at 346 nm and can be used to analyze this group of compounds.
The content of the sum of flavonoids in the aboveground part of the crested helmet varies from 9.72% to 10.27%. In order to establish the optimal harvesting time of plant raw materials, the content of the sum of flavonoids was determined by the vegetation periods of the plant in terms of isoscutellarein 7-O-β-D-glucopyranoside and it was determined that the maximum accumulation of the sum of flavonoids is observed during the flowering period (10.13% of the weight of air-dry raw materials).
The interactions between inflammation and insulin resistance: prospects of immunoregulation as a potential approach for the type 2 diabetes mellitus treatment
Authors: Stafeev I. S. , Yudaeva A. D. , Michurina S. S. , Menshikov M. Yu. , Shestakova M. V. , Parfyonova Y. V. 
Published: May 2023

In the modern world the prevalence of obesity and type 2 diabetes mellitus (T2DM) significantly increases. In this light the risks of obesity-associated complications also grow up. The crucial linkage between obesity and its complications is inflammation, which is a convenient target for potential anti-diabetic therapy. There are some anti-inflammatory therapy strategies: action on secreted cytokines, circulating lipids or intracellular signaling cascades. Canakinumab (antibody to IL-1b receptor) and colchicine (IL-6 secretion blocker) have the most balanced anti-diabetic and cardioprotective action among cytokine anti-inflammatory therapy. Lipid-lowering therapy is very diverse, but bempedoic acid nowadays has the best combination of anti-inflammatory and cardioprotective effects. Salicylate is an inhibitor of IKK-dependent inflammatory signaling cascade and significantly lowers glycated hemoglobin and C-reactive protein levels among obese patients. The future of anti-inflammatory T2DM therapy can be related with anti-inflammatory cytokines (IL-4, IL-37), chimeric engineered cytokines (IC7Fc), novel inhibitors of inflammatory and cytokines signaling cascades (imatinib, CC90001) and cell-based therapy (mesenchymal stem cells). In summary, despite on the limitations of current clinical trials, anti-inflammatory drugs have a potential to become a part of modern combined T2DM therapy with anti-diabetic and cardioprotective properties. Novel findings in potential anti-inflammatory T2DM therapy have great perspectives in protection against T2DM and related complication prevention.
Design of a novel hybrid soft computing model for passive components selection in multiple load Zeta converter topologies of solar PV energy system
Authors: Hole Shreyas Rajendra , Goswami Agam Das 
Published: May 2023

Abstract
This paper presents a new approach to improve the performance of Zeta converters, which are commonly used in cost-sensitive circuits to manage unregulated power supply. The converters are designed to produce positive output voltages based on input voltages, and they use a buck controller to power a PMOS-based FET for high-side control. Compared to other converters, such as SEPIC, Zeta converters are smaller and more scalable for micro applications due to the use of coupled inductor circuits. The performance of Zeta converters is heavily influenced by the ratings of their passive components. To optimize component rating choices, researchers have developed several pattern analysis models. However, these models often require context-specific ratings and lack a parameter selection method for continual reconfigurations, making them difficult to deploy in practice for different use cases. To address these limitations, the authors propose a hybrid soft computing methodology for passive component selection in multiple load Zeta converters. The proposed approach combines Particle Swarm Optimization (PSO) to determine initial component ratings and Grey Wolf Optimization (GWO) to improve conversion efficiency, output gain, and Total Harmonic Distortion (THD). This is achieved by modeling a fitness function that incorporates output metrics and optimizes them incrementally for real-time deployments. The results show that the suggested methodology can reduce THD by 6.5 %, increase conversion efficiency by 3.4 %, and maintain a gain improvement of 1.5 % across numerous use cases. These improvements make the model suitable for real-time use applications. Overall, the proposed approach provides a promising solution to the challenges of passive component selection in Zeta converters, which can lead to more efficient and cost-effective power management in various circuits.
Green synthesis of silver nanoparticles using Callisia fragrans leaf extract and its anticancer activity against MCF-7, HepG2, KB, LU-1, and MKN-7 cell lines
Authors: Nguyen Lan Anh Thi , Van Mai Bay , Van Nguyen Din , Nguyen Ngoc Quyen Thi , Van Pham Vuong , Pham Thong Le Minh , Le Hai Tu 
Published: May 2023

Abstract
This article presents a simple, eco-friendly, and green method for the synthesis of silver nanoparticles (AgNPs) from AgNO3 solution utilizing an aqueous extract of Callisia fragrans leaf. The effects of C. fragrans leaf extraction conditions were evaluated. Parameters affecting the synthesis of AgNPs, such as the volume of extract, pH, temperature, and reaction time were investigated and optimized. The obtained AgNPs were analyzed by UV–Vis spectroscopy, X-ray diffraction pattern, energy-dispersive X-ray spectroscopy, field emission scanning electron microscopy, transmission electron microscopy (TEM), dynamic light scattering (DLS), and FTIR techniques. TEM and DLS analyses have shown that the synthesized AgNPs were predominantly spherical in shape with an average size of 48 nm. The zeta potential of the colloidal solution of AgNPs is −27 mV, indicating the dispersion ability of AgNPs. The results of GC–MS and FTIR analyses show the presence of biomolecules in the aqueous extract of C. fragrans leaf that acts as reducing and capping agents for the biosynthesis of AgNPs. The synthesized AgNPs demonstrate anticancer activity against MCF-7, HepG2, KB, LU-1, and MKN-7 cell lines, with inhibitory concentrations at 50% (IC50 values) of 2.41, 2.31, 2.65, 3.26, and 2.40 µg·mL−1, respectively. The obtained results in the study show that the biosynthesized AgNP from C. fragrans leaf extract can be further exploited as a potential candidate for anticancer agents.
Sémiotique destextscapes: quelle contribution dutextscapelinguistique à la mise en scène des langues dans un corpus de sites web ?
Authors: Hermand Marie-Hélène 
Published: May 2023

RésuméCet article propose une réflexion théorique et méthodologique permettant de décrire et d’interpréter lestextscapesà des fins d’analyse communicationnelle. L’objectif consiste à tester le concept sémiotique detextscapelinguistique pour analyser la mise en scène des langues dans la communication des organisations sur le web. Le cadre théorique fait appel aux études du paysage linguistique (Linguistic Landscape Studies) et à la théorie des paysages textuels (textscapes). Le corpus est composé de 100 sites web d’organisations économiques (chambres de commerce,clusterséconomiques, entreprises) qui revendiquent un positionnement à l’échelle transfrontalière européenne. L’étude est menée d’un point de vue statistique (analyse de métadonnées) et qualitatif (analyse sémiotique dutextscapelinguistique) en vue de préciser la place et les fonctions communicationnelles dutextscapelinguistique dans la communication multilingue. Les résultats ont permis de dégager les profils d’expression, un scénario sémiotique typique des sites web observés et surtout de localiser les (dés)équilibres communicationnels.
Entre Lourdes Castro e Ana Paula Barbosa: O jardim como poética
Authors: Senna Nádia da Cruz , Rosa da Silva Ursula 
Published: May 2023

O artigo apresenta o encontro entre Lourdes Castro, reconhecida artista portuguesa, com Ana Paula Barbosa, jovem artista do Sul do Brasil, a partir da proposição teórica do Museu Feminista Virtual. A abordagem estabelece uma conexão para destacar afinidades entre processos, reflexões e invenções artísticas que envolvem a natureza, as práticas cotidianas, a memória e os afetos.Palavras-chave: arte e natureza; mulheres artistas; práticas cotidianas. Between Lourdes Castro and Ana Paula Barbosa: The garden as poetic Abstract: This paper presents the meeting between Lourdes Castro, a recognized Portuguese artist, and Ana Paula Barbosa, a young artist from southern Brazil, based on the theoretical proposition of the Museu Feminista Virtual [Virtual Feminist Museum]. The approach establishes a connection to highlight links between artistic processes, critical reflection and inventions that involve nature, everyday practices, memory and affection.Keywords: Art and nature. Women artists. Everyday practices.
Imagen y creación, grupo de investigación que actúa en el noroeste de México
Authors: Huerta Jiménez Mayra 
Published: May 2023

El grupo de investigación Imagen y Creación 1 conformado por profesores de la Universidad Autónoma de Baja California, ha generado durante siete años diversos proyectos. La intención de este ensayo es mostrar los eventos o sucesos académicos, que varían desde una exposición colectiva de gráfica, o fotografía hasta proyectos que involucran a estudiantes en procesos de creación con una serie de convicciones fuera del aula. Es decir, salir del recinto universitario, para abordar problemáticas de un contexto específico en la ciudad. Por nuestra ubicación geográfica, hablamos de un estado con dos ciudades fronterizas completamente distintas: la ciudad de Tijuana y Mexicali ambas con garitas que son los cruces con Estados Unidos, pero ambas mantienen singularidades por densidad de población, por densidad de deportados e inmigrantes que arriban para cruzar cada año. Por esta razón, el término frontera y migración son fenómenos que trascienden a todo el territorio. Mostraremos estos fenómenos con aspectos colaborativos y reflexivos para aportar al campo del arte con la realización de la práctica artística. Por otro lado, conformamos parte de una red temática en el Simposio de Investigación en Arte: Migrando, Interviniendo y Des-localizando con la Universidad Federal do Rio Grande do Sul y la Universidad Federal de Santa en la región de Porto Alegre, Brasil.Palabras clave: Creación; Frontera; Investigación; Acción; Red. Image and creation, a research group operating in northwestern Mexico.Abstract: The research group Image and Creation is made up of professors from the Universidad Autónoma de Baja California and which has generated various projects for seven years. The intention of this paper is to show events or academic productions, which vary from group shows featuring graphic design and photography to projects that involve students and their creative processes, as well as a series of convictions outside the classroom. These practices imply leaving the university campus to address problems in a specific urban context. Due to its geographic location, the paper talks about a state with two different border cities: the city of Tijuana and Mexicali, both having their own United States Customs and Border Protection agencies, serving as the border crossing point, but both maintaining their own unique characteristics, due to population density and the density of deportees and immigrants who arrive each year. For this reason, the term border and migration can be seen as phenomena that transcend the entire territory. We will show the collaborative and reflective aspects of these phenomena, and how they contribute to the field of art and artistic practice. This paper has been produced as part of a thematic network of the Art Research Symposium: Migrating, Intervening and Relocating with the Federal University do Rio Grande do Sul and the Federal University of Santa in the region of Porto Alegre, RS, Brazil. Keywords: Creation; Frontier; Research; Network; Action.
O espaço autobiogeográfico em construção
Authors: Afonso Rodrigues Manoela dos Anjos 
Published: May 2023

Neste artigo, apresento a disciplina Laboratório de Práticas Autobiogeográficas e destaco o fazer ar tístico que se dá como prática de si criticamente situada na convergência entre Ar tes Visuais, Estudos Auto/Biográf icos e Estudos Decoloniais. Nesse contexto, observo a emergência do espaço autobiogeográf ico como campo de experimentação de poéticas de (auto)localização que confrontam a colonialidade do ser, do sentir e do saber.Palavras-chave: Autobiogeografia; Espaço Autobiogeográfico; Autobiografia; Espaço Autobiográfico; Artes Visuais. El espacio autobiogeográfico en construcciónResumen: In this article, I present the subject Laboratory of Autobiogeographical Practices and highlight the art-making that takes place as a practice of the self critically situated in the convergence between Visual Arts, Auto/Biographical Studies, and Decolonial Studies. In this context, I observe the emergence of the autobiogeographical space as a field of experimentation for poetics of (self ) location that confront coloniality of being, sensing, and knowing.Palabras clave: Autobiogeography; Autobiogeographical Space; Autobiography; Autobiographical Space; Visual Arts.
Value-Based Care for Healthy Children With First Episode of Febrile Neutropenia
Authors: Grandjean-Blanchet Charlotte , Le Cathie-Kim , Villeneuve Stephanie , Cada Michaela , Beck Carolyn E. , Science Michelle , Rosenfield Daniel , Ostrow Olivia 
Published: May 2023

OBJECTIVES
There is a lack of guidance on the management of febrile neutropenia in otherwise healthy children, including the need for hospitalization and antibiotic administration, leading to significant practice variation in management. The aim of this initiative was to decrease the number of unnecessary hospitalizations and empirical antibiotics prescribed by 50% over a 24-month period for well-appearing, previously healthy patients older than 6 months presenting to the emergency department with a first episode of febrile neutropenia.

METHODS
A multidisciplinary team of stakeholders was assembled to develop a multipronged intervention strategy using the Model for Improvement. A guideline for the management of healthy children with febrile neutropenia was created, coupled with education, targeted audit and feedback, and reminders. Statistical control process methods were used to analyze the primary outcome of the percentage of low-risk patients receiving empirical antibiotics and/or hospitalization. Balancing measures included missed serious bacterial infection, emergency department (ED) return visit, and a new hematologic diagnosis.

RESULTS
Over the 44-month study period, the mean percentage of low-risk patients hospitalized and/or who received antibiotics decreased from 73.3% to 12.9%. Importantly, there were no missed serious bacterial infections, no new hematologic diagnoses after ED discharge, and only 2 ED return visits within 72 hours without adverse outcomes.

CONCLUSIONS
A guideline for the standardized management of febrile neutropenia in low-risk patients increases value-based care through reduced hospitalizations and antibiotics. Education, targeted audit and feedback, and reminders supported sustainability of these improvements.
Pediatric Antiretroviral Therapy Coverage and AIDS Deaths in the “Treat All” Era
Authors: Rosen Joseph G. , Muraleetharan Ohvia , Walker Allison , Srivastava Meena 
Published: May 2023

OBJECTIVES
In 2015, CD4-based clinical staging criteria for antiretroviral therapy (ART) initiation were removed, expanding ART eligibility (“Treat All”) for children, who shoulder an outsized burden of HIV-related deaths. To quantify the impact of “Treat All” on pediatric HIV outcomes, we examined shifts in pediatric ART coverage and AIDS mortality before and after “Treat All” implementation.

METHODS
We abstracted country-level ART coverage (proportion of children &lt;15 years on ART) and AIDS mortality (deaths per 100 000 population) estimates over 11 years. For 91 countries, we also abstracted the year “Treat All” was incorporated into national guidelines. We used multivariable 2-way fixed effects negative binomial regression to estimate changes in pediatric ART coverage and AIDS mortality potentially attributable to “Treat All” expansion, reported as adjusted incidence rate ratios (adj.IRR) with 95% confidence intervals (95% CI).

RESULTS
From 2010 to 2020, pediatric ART coverage tripled (16% to 54%), and AIDS-related deaths were halved (240 000 to 99 000). Compared with the pre-implementation period, observed ART coverage continued increasing after “Treat All” adoption, but this rate of increase declined by 6% (adj.IRR = 0.94, 95% CI: 0.91–0.98). AIDS mortality continued declining after “Treat All” adoption, but this rate of decline decreased by 8% (adj.IRR = 1.08, 95% CI: 1.05–1.11) in the post-implementation period.

CONCLUSIONS
Although “Treat All” called for increased HIV treatment equity, ART coverage continues lagging in children and comprehensive approaches that address structural issues, including family-based services and intensified case-finding, are needed to close pediatric HIV treatment gaps.
Penentuan Padat Penebaran Optimal Pendederan Bandeng (Chanos chanos) dalam Hapa di Tambak Tanah Gambut
Authors: Syahrir Muhammad 
Published: May 2023

Penelitian ini bertujuan untuk mendapatkan padat penebaran optimal pada pendederan bandeng dalam tambak tanah gambut. Padat penebaran yang dicoba adalah 200, 300, 400 dan 500 ekor per 1,0 m3, dengan sistem hapa dan masing-masing diulang tiga kali. Wadah pemeliharaan terbuat dari polyethylene denganukuran 0,8 mm dan dipasang pada patok bambu. Berat awal dan panjang total nener masing-masing adalah 0,01 g dan 16,3 mm. Selama pemeliharaan (21 hari), nener diberi pakan remah, tiga kali sehari dengan dosis menurun dari 100 sampai 15% berat per hari. Pergantian air dilakukan setiap 2 hari sekali secara garavitasi atau dengan menggunakan pompa. Hasil penelitian menunjukkan bahwa padat penebaran yang dicoba belum berpengaruh nyata(p>0,05) terhadap pertumbuhan berat mutlak, laju pertumbuhan harian, kelangsungan hidup 96,18% dan rasio konversi pakan 1,9. Padat penebaran 400 ekor nener / m kubik memberi pertumbuhan absolut terbaik yaitu 0,27 g, pertumbuhan harian 18,1%, kelulusan hidup 96,18 %, biomassa 90,30 g dan konversi pakan 1,90.
Social return on investment – does the tool work in practice?
Authors: Głowacki Jakub 
Published: May 2023

Background: This text was created as a consequence of reading the article entitled "Using the social return on investment (SROI) as a measure of the effectiveness of social innovation projects implemented under public policies" published in the Social Enterprise Journal.
Research objectives: This article aims to contribute to the ongoing debate about the best way to measure the economic effectiveness of public policies, as well to explore the possibility of using the SROI method as one of the indicators.
Research design and methods: The paper is based on Google Trends analysis and previous project results.