bluuebunny/crossref_metadata_2025_split huggingface dataset:
Randomized Double-Blind Phase II Trial of Fecal Microbiota Transplantation Versus Placebo in Allogeneic Hematopoietic Cell Transplantation and AML
Authors: Rashidi Armin , Ebadi Maryam , Rehman Tauseef Ur , Elhusseini Heba , Kazadi David , Halaweish Hossam , Khan Mohammad H. , Hoeschen Andrea , Cao Qing , Luo Xianghua , Kabage Amanda J. , Lopez Sharon , Holtan Shernan G. , Weisdorf Daniel J. , Khoruts Alexander , Staley Christopher 
Published: May 2023

PURPOSE Gut microbiota injury in allogeneic hematopoietic cell transplantation (HCT) recipients and patients with AML has been associated with adverse clinical outcomes. Previous studies in these patients have shown improvements in various microbiome indices after fecal microbiota transplantation (FMT). However, whether microbiome improvements translate into improved clinical outcomes remains unclear. We examined this question in a randomized, double-blind, placebo-controlled phase II trial. METHODS Two independent cohorts of allogeneic HCT recipients and patients with AML receiving induction chemotherapy were randomly assigned in a 2:1 ratio to receive standardized oral encapsulated FMT versus placebo upon neutrophil recovery. After each course of antibacterial antibiotics, patients received a study treatment. Up to three treatments were administered within 3 months. The primary end point was 4-month all-cause infection rate. Patients were followed for 9 months. RESULTS In the HCT cohort (74 patients), 4-month infection density was 0.74 and 0.91 events per 100 patient-days in FMT and placebo arms, respectively (infection rate ratio, 0.83; 95% CI, 0.48 to 1.42; P = .49). In the AML cohort (26 patients), 4-month infection density was 0.93 in the FMT arm and 1.25 in the placebo arm, with an infection rate ratio of 0.74 (95% CI, 0.32 to 1.71; P = .48). Unique donor bacterial sequences comprised 25%-30% of the fecal microbiota after FMT. FMT improved postantibiotic recovery of microbiota diversity, restored several depleted obligate anaerobic commensals, and reduced the abundance of expanded genera Enterococcus, Streptococcus, Veillonella, and Dialister. CONCLUSION In allogeneic HCT recipients and patients with AML, third-party FMT was safe and ameliorated intestinal dysbiosis, but did not decrease infections. Novel findings from this trial will inform future development of FMT trials.
Time-dependent probability density function analysis of H-mode transitions
Authors: Farre-Kaga Hiro J. , Andrew Yasmin , Dunsmore Jamie , Kim Eun-jin , Rhodes Terry L. , Schmitz Lothar , Yan Zheng 
Published: May 2023

Abstract
The first application of time-dependent probability density function (PDF) analysis to the L-H transition in fusion plasmas is presented. PDFs are constructed using Doppler Backscattering data of perpendicular fluctuation velocity,

, and turbulence from the edge region of the DIII-D tokamak. These raw time-series data are sliced into millisecond-long sliding time-windows to create PDFs. During the transition, the

PDFs develop strong right tails, indicative of turbulence-suppressing localised flows in the plasma edge; such features and other subtle behaviours are explored using novel information geometry techniques. This letter examines the applicability of these techniques to predict L-H transitions and investigate predator-prey self-regulation theories between turbulence and perpendicular velocity.
Paricalcitol and Extended-Release Calcifediol for Treatment of Secondary Hyperparathyroidism in Non-Dialysis Chronic Kidney Disease: Results From a Network Meta-Analysis
Authors: Franchi Matteo , Gunnarsson Joel , Gonzales-Parra Emilio , Ferreira Anibal , Ström Oskar , Corrao Giovanni 
Published: May 2023

Abstract

Context
Secondary hyperparathyroidism (SHPT) is a complication of chronic kidney disease (CKD) affecting mineral and bone metabolism and characterized by excessive parathyroid hormone (PTH) production and parathyroid hyperplasia.

Objective
The objective of this analysis was to compare the efficacy and adverse effects of extended-release calcifediol (ERC) and paricalcitol (PCT) by assessing their effect on the biomarkers PTH, calcium, and phosphate in patients with non-dialysis CKD (ND-CKD).

Methods
A systematic literature research was performed in PubMed to identify randomized control trials (RCTs). Quality assessment was done with the GRADE method. The effects of ERC vs PCT were compared using random effects in a frequentist setting.

Results
Nine RCTs comprising 1426 patients were included in the analyses. The analyses were performed on 2 overlapping networks, due to nonreporting of outcomes in some of the included studies. No head-to-head trials were identified. No statistically significant differences in PTH reduction were found between PCT and ERC. Treatment with PCT showed statistically significant increases in calcium compared with ERC (0.2 mg/dL increase; 95% CI, −0.37 to −0.05 mg/dL). No differences in effects on phosphate were observed.

Conclusion
This network meta-analysis showed that ERC is comparable in lowering PTH levels vs PCT. ERC displayed avoidance of potentially clinically relevant increases in serum calcium, offering an effective and well-tolerated treatment option for the management of SHPT in patients with ND-CKD.
Shelter from the Storm: Cynicism and the Refuge of Meaning
Authors: Parker Ben 
Published: May 2023

AbstractIn her new book on the function of cynicism, Helen Small defines a positive role that cynicism can play in the liberal articulation of the very ideals and norms that cynicism affronts. She provides this “strategic cynicism” with a nineteenth-century lineage including Friedrich Nietzsche, Matthew Arnold, George Eliot, and Thomas Carlyle. This review essay identifies some problems in the concept of strategic cynicism, drawing on Hegel's understanding of intentional action. Strategic cynicism is ultimately a role-playing (or impersonation) of cynicism by normativity on its own behalf. As Small conceives norms, they are vulnerable to cynicism because they are stranded and without immanent grounding. Turning to Henry James's novel The Awkward Age, this essay shows how cynicism can be answered not by pointing to better intentions, but only by what we discover retrospectively, from the consequences of how things turn out, our commitments to be. The essay ends with a consideration of the dysfunction of liberal responses to Donald Trump's cynicism.
The Making of the Hindu Normative
Authors: Ghosh Bishnupriya 
Published: May 2023

Abstract
This essay reviews Anustup Basu's book Hindutva as Political Monotheism (2020) in the context of current debates over Hindu political theology after the Bharatiya Janata Party's electoral wins of 2014 and 2018. The book charts the consolidation of Hinduism as a monotheistic imperative ever since its inception in the second decade of the nineteenth century, and its axiomatic place in present-day masculinist majoritarian India—“Modi's India.” This review places the book's historical reading of political Hinduism and its arguments on an informatic Hindutva mediascape (Hindutva 2.0) alongside recent books with similar ambitions.
Problematic use of the internet, smartphones, and social media among medical students and relationship with depression: An exploratory study
Authors: Sserunkuuma Jonathan , Kaggwa Mark Mohan , Muwanguzi Moses , Najjuka Sarah Maria , Murungi Nathan , Kajjimu Jonathan , Mulungi Jonathan , Kihumuro Raymond Bernard , Mamun Mohammed A. , Griffiths Mark D. , Ashaba Scholastic 
Published: May 2023

Background
Students in sub-Saharan African countries experienced online classes for the first time during the COVID-19 pandemic. For some individuals, greater online engagement can lead to online dependency, which can be associated with depression. The present study explored the association between problematic use of the internet, social media, and smartphones with depression symptoms among Ugandan medical students.

Methods
A pilot study was conducted among 269 medical students at a Ugandan public university. Using a survey, data were collected regarding socio-demographic factors, lifestyle, online use behaviors, smartphone addiction, social media addiction, and internet addiction. Hierarchical linear regression models were performed to explore the associations of different forms of online addiction with depression symptom severity.

Results
The findings indicated that 16.73% of the medical students had moderate to severe depression symptoms. The prevalence of being at risk of (i) smartphone addiction was 45.72%, (ii) social media addiction was 74.34%, and (iii) internet addiction use was 8.55%. Online use behaviors (e.g., average hours spent online, types of social media platforms used, the purpose for internet use) and online-related addictions (to smartphones, social media, and the internet) predicted approximately 8% and 10% of the severity of depression symptoms, respectively. However, over the past two weeks, life stressors had the highest predictability for depression (35.9%). The final model predicted a total of 51.9% variance for depression symptoms. In the final model, romantic relationship problems (ß = 2.30, S.E = 0.58; p<0.01) and academic performance problems (ß = 1.76, S.E = 0.60; p<0.01) over the past two weeks; and increased internet addiction severity (ß = 0.05, S.E = 0.02; p<0.01) was associated with significantly increased depression symptom severity, whereas Twitter use was associated with reduced depression symptom severity (ß = 1.88, S.E = 0.57; p<0.05).

Conclusion
Despite life stressors being the largest predictor of depression symptom score severity, problematic online use also contributed significantly. Therefore, it is recommended that medical students’ mental health care services consider digital wellbeing and its relationship with problematic online use as part of a more holistic depression prevention and resilience program.
Efficacy and safety of keverprazan compared to lansoprazole in the treatment of duodenal ulcer: a phase III, randomised, double-blind, multicentre trial
Authors: Tan Nian-di , Miao Xin-pu , Liao Ai-jun , Liu Cheng-xia , Wu Hao , Chen Hong-hui , Li Fang-fang , Guo Qing-hong , Li Sheng-bao , Tang Yan-ping , Xia Min , Liu You-li , Li Xing , Chen Hui-xin , Liu Xiao-wei , Zhang Yan , Zhang Zhen-yu , Chen Min-hu , Xiao Ying-lian 
Published: May 2023

Abstract

Introduction:
Keverprazan is a novel potassium-competitive acid blocker for the treatment of acid-related disorders requiring potent acid inhibition. This study aimed to establish the non-inferiority of keverprazan to lansoprazole in treatment of patients with duodenal ulcer (DU).

Methods:
In this phase III, double-blind, multicentre study, 360 Chinese patients with endoscopically conﬁrmed active DU were randomised 1:1 to take either keverprazan (20 mg) or lansoprazole (30 mg) treatment for up to 6 weeks. The primary endpoint was DU healing rate at week 6. The secondary endpoints were DU healing rate at week 4. Symptom improvement and safety were also assessed.

Results:
Based on full analysis set, the cumulative healing rates at week 6 were 94.4% (170/180) and 93.3% (166/178) for keverprazan and lansoprazole, respectively (difference: 1.2%; 95% CI: –4.0% to 6.5%). At week 4, the respective healing rates were 83.9% (151/180) and 80.3% (143/178). In per-protocol set, the 6-week healing rates in keverprazan and lansoprazole groups were 98.2% (163/166) and 97.6% (163/167), respectively (difference: 0.6%; 95% CI: –3.1% to 4.4%); the 4-week healing rates were respectively 86.8% (144/166) and 85.6% (143/167). Keverprazan was non-inferior to lansoprazole in DU healing after the treatment for 4 and 6 weeks. The incidence of treatment- emergent adverse events was comparable among groups.

Conclusions:
Keverprazan 20 mg had a good safety profile and was non-inferior to lansoprazole 30 mg once daily for DU healing.
Molecular functions of RNA helicases during ribosomal subunit assembly
Authors: Khreiss Ali , Bohnsack Katherine E. , Bohnsack Markus T. 
Published: May 2023

Abstract
During their biogenesis, the ribosomal subunits undergo numerous structural and compositional changes to achieve their final architecture. RNA helicases are a key driving force of such remodelling events but deciphering their particular functions has long been challenging due to lack of knowledge of their molecular functions and RNA substrates. Advances in the biochemical characterisation of RNA helicase activities together with new insights into RNA helicase binding sites on pre-ribosomes and structural snapshots of pre-ribosomal complexes containing RNA helicases now open the door to a deeper understanding of precisely how different RNA helicases contribute to ribosomal subunit maturation.
Competing factors in SLA: how the CASP model of SLA explains the acquisition of English restrictive relative clauses by native speakers of Arabic and Korean
Authors: Hitz John 
Published: May 2023

Abstract
The Complex Adaptive Systems Principles (CASP) model of SLA claims that L1 transfer results when language processing effort is minimized. This claim was investigated by a self-paced on-line sentence judgment task in which L1 Arabic and Korean speakers and a control group of L1 English speakers read and judged English subject, direct object, and oblique relative clauses (RCs) in gapped and resumptive pronoun (RP) conditions. It was hypothesized that L1 influence would cause the Arabic speakers to accept English RCs with RPs more frequently than Korean speakers because RPs are acceptable in Arabic direct object and oblique RCs, whereas Korean bans RPs in these RC types. It was also hypothesized that the L2 English speakers would accept RPs more often than the L1 English speakers because RPs would ease L2 sentence processing. As predicted, L1 Arabic speakers accepted RPs more frequently than L1 Korean speakers, a transfer effect, and both L2 English groups accepted RPs more frequently than L1 English speakers, a processing effect. The results thus support the CASP model’s claim that L1 transfer is conditioned by language processing and other complex SLA processes that interact with one another.
Influence of graphene coating in electrical discharge machining with an aluminum electrode
Authors: Pham Van Dong , Shirguppikar Shailesh , Huu Phan Nguyen , Thangaraj Muthuramalingam , Le Thi Phuong Thanh , Trong Ly Nguyen , Ganachari Vaibhav 
Published: May 2023

Abstract
Since the cost of electrodes in electrical discharge machining (EDM) is usually too high, it leads to a significant increase in the production cost. Hence, it is important to conduct research aimed at reducing the manufacturing cost of electrodes. Currently, coated electrodes are a new process solution in EDM. It can improve the economic and technical efficiency of this technology. In this article, the efficiency of the graphene-coated aluminum (Al) electrode in the EDM for Ti–6Al–4V was analyzed and evaluated. Material removal rate and tool wear rate were used as quality indicators in this work. The research results have shown a significant improvement in quality characteristics in EDM with coated electrodes compared to EDM with uncoated electrodes. The surface quality of the specimen with coated electrodes in EDM was also improved.
Review of wrongful convictions following police misconduct: A study of the English Criminal Cases Review Commission
Authors: Hoyle Carolyn 
Published: May 2023

Abstract
The Criminal Cases Review Commission (CCRC) reviews possible wrongful convictions in England, Wales, and Northern Ireland, referring back to the Court of Appeal cases where there is a ›real possibility‹ that the conviction is unsafe. This article presents findings from a four-year empirical study of decision-making within the CCRC. It explores how Commission staff exercise discretionary powers in identifying and investigating possible wrongful convictions, referring just a few back to the Court.<fnote> Since its inception in April 1997, the CCRC has received almost 29,000 applications and referred 797 back to the Court of Appeal. Of these referrals, the Court has quashed the conviction in 542 cases. In 2019-20, the CCRC received 1,334 applications, and in 2020-21, 1,142.</fnote>
It focuses on a sample of cases that turned on police misconduct in pursuit of a socio-legal contribution to our understanding of the response of the state to claims of wrongful conviction. It demonstrates that caseworkers’ approaches to investigation and decision-making is shaped by the law and internal policies such that reasonably consistent decision frames emerge.
Monkeypox scenario in India: a review study
Authors: William Ashish , Madan Molly 
Published: May 2023

AbstractThe monkeypox virus, which causes the viral zoonotic disease, is known as the most significant orthopoxvirus infection following the elimination of smallpox. The monkeypox virus, which was previously exclusive to West and Central African nations and caused endemic diseases in monkeys and people, has recently been linked to human infections in non-endemic areas including the United States of America (USA) and more than 30 additional countries. Guidelines for the diagnosis and treatment of monkeypox have also recently been made available by the Ministry of Health and Family Welfare of India and the Indian Government. The monkeypox outbreak continues to be a worldwide health emergency, the highest degree of alert recognised by the World Health Organization. The Centers for Disease Control and Prevention (CDC) advises vaccination for those who have been exposed to the disease as well as those who may be at higher risk of contracting it, such as those who have been identified by public health officials as a contact of someone who has the disease.
Design analysis and manufacture of a variable load effective wear machine
Authors: Ateş Ergun 
Published: May 2023

Abstract
A variable load effective wear machine was designed, analyzed using the finite element method, and manufactured after its strength was verified. The creation of the solid design model and the finite element analysis were performed in the SolidWorks program. In the wear machine, the abrasive, attached to a plate that can move linearly back and forth, is in contact with the surface of a material to be tested in a fixed position. In the system, the movement is repeated periodically twice in each cycle. The operation of the design system is explained by the calculation of the reaction force and strength under different loads, depending on certain settings. The wear machine was able to operate successfully for a maximum of 30 N loads and up to 30 min in the wear tests. Compared to linear motion wear machines operating with constant speed and a constant load effect, the manufactured wear machine can better explain the wear mechanism between contact materials as a “constant load-variable load effect”.
Attention without Constraint: Alpha Lateralization in Uncued Willed Attention
Authors: Nadra John G. , Bengson Jesse J. , Morales Alexander B. , Mangun George R. 
Published: May 2023

AbstractStudies of voluntary visual spatial attention have used attention-directing cues, such as arrows, to induce or instruct observers to focus selective attention on relevant locations in visual space to detect or discriminate subsequent target stimuli. In everyday vision, however, voluntary attention is influenced by a host of factors, most of which are quite different from the laboratory paradigms that use attention-directing cues. These factors include priming, experience, reward, meaning, motivations, and high-level behavioral goals. Attention that is endogenously directed in the absence of external attention-directing cues has been referred to as “self-initiated attention” or, as in our prior work, as “willed attention” where volunteers decide where to attend in response to a prompt to do so. Here, we used a novel paradigm that eliminated external influences (i.e., attention-directing cues and prompts) about where and/or when spatial attention should be directed. Using machine learning decoding methods, we showed that the well known lateralization of EEG alpha power during spatial attention was also present during purely self-generated attention. By eliminating explicit cues or prompts that affect the allocation of voluntary attention, this work advances our understanding of the neural correlates of attentional control and provides steps toward the development of EEG-based brain–computer interfaces that tap into human intentions.
Neuronally Derived Soluble Abeta Evokes Cell-Wide Astrocytic Calcium Dysregulation in Absence of Amyloid Plaquesin Vivo
Authors: Kelly Patricia , Sanchez-Mico Maria V. , Hou Steven S. , Whiteman Sara , Russ Alyssa , Hudry Eloise , Arbel-Ornath Michal , Greenberg Steven M. , Bacskai Brian J. 
Published: May 2023

The key pathologic entities driving the destruction of synaptic function and integrity during the evolution of Alzheimer's disease (AD) remain elusive. Astrocytes are structurally and functionally integrated within synaptic and vascular circuitry and use calcium-based physiology to modulate basal synaptic transmission, vascular dynamics, and neurovascular coupling, which are central to AD pathogenesis. We used high-resolution multiphoton imaging to quantify all endogenous calcium signaling arising spontaneously throughout astrocytic somata, primary processes, fine processes, and capillary endfeet in the brain of awake APP/PS1 transgenic mice (11 male and 6 female mice). Endogenous calcium signaling within capillary endfeet, while surprisingly as active as astrocytic fine processes, was reduced ∼50% in the brain of awake APP/PS1 mice. Cortical astrocytes, in the presence of amyloid plaques in awake APP/PS1 mice, had a cell-wide increase in intracellular calcium associated with an increased frequency, amplitude, and duration of spontaneous calcium signaling. The cell-wide astrocytic calcium dysregulation was not directly related to distance to amyloid plaques. We could re-create the cell-wide intracellular calcium dysregulation in the absence of amyloid plaques following acute exposure to neuronally derived soluble Abeta from Tg2576 transgenic mice, in the living brain of male C57/Bl6 mice. Our findings highlight a role for astrocytic calcium pathophysiology in soluble-Abeta mediated neurodegenerative processes in AD. Additionally, therapeutic strategies aiming to protect astrocytic calcium physiology from soluble Abeta-mediated toxicity may need to pharmacologically enhance calcium signaling within the hypoactive capillary endfeet while reducing the hyperactivity of spontaneous calcium signaling throughout the rest of the astrocyte.SIGNIFICANCE STATEMENTAstrocytic calcium signaling is functionally involved in central pathologic processes of Alzheimer's disease. We quantified endogenous calcium signaling arising spontaneously in the brain of awake APP/PS1 mice, as general anesthesia suppressed astrocytic calcium signaling. Cell-wide astrocytic calcium dysregulation was not related to distance to amyloid plaques but mediated in part by neuronally derived soluble Abeta, supporting a role for astrocytes in soluble-Abeta mediated neurodegeneration. Spontaneous calcium signaling is largely compartmentalized and capillary endfeet were as active as fine processes but hypoactive in the presence of amyloid plaques, while the rest of the astrocyte became hyperactive. The cell-wide calcium pathophysiology in astrocytes may require a combination therapeutic strategy for hypoactive endfeet and astrocytic hyperactivity.