bluuebunny/crossref_metadata_2025_split huggingface dataset:
Model of Blue Ocean Strategy Developing a Bamboo Small Business in Medan City
Authors: Samrin  , Hasibuan Hasrul Azwar , Rahmat Hidayat  , Rusiadi  
Published: July 2023

The research objective is to analyze the Blue Oceans Strategy method approach to improve strategy development for the Small and Medium Bamboo Industry in Medan City. Woven crafts are one of the most abundant businesses in the SME sector, both rattan and bamboo handicrafts have dominated the activities of SMEs in Medan City . The woven crafts are spread in 5 (five) sub-districts in Medan City. The method of analysis in this study uses a Structural Equation Modeling (SEM) approach, in forming a strategy for developing SMEs and Bamboo cooperatives with the ocean strategy and blue ocean strategy models in Medan City. The competitive strategy used by the Small and Medium Shell Industry in Medan City at this time is to identify competitive factors in the industry which consist of product uniqueness, a touch of art, done in detail, proximity to sources of raw materials, strategic location, availability of labor, Creativity, Prices are not fixed on market prices, Can be used as souvenirs, Skills and skills of employees, Attractiveness and impact after participating in exhibitions, Sensitivity to market choices, Organizational commitment, Work environment, Availability of online order facilities, Experience and managerial skills, Product orders completed on time.
ปัจจัยที่ส่งผลต่อการปรับตัวด้านการเงินของประชาชนในจังหวัดสุพรรณบุรี ภายใต้สถานการณ์การแพร่ระบาดของโรคติดเชื้อไวรัสโคโรนา 2019
Authors: Kookkaew Pathompong , แสนภักดี พิธาน 
Published: July 2023

การวิจัยนี้มีวัตถุประสงค์เพื่อวิเคราะห์ปัจจัยที่สามารถพยากรณ์การปรับตัวด้านการเงิน และสร้างสมการพยากรณ์การปรับตัวด้านการเงินของประชาชนในจังหวัดสุพรรณบุรีภายใต้สถานการณ์การแพร่ระบาดของโรคติดเชื้อไวรัสโคโรนา 2019 เป็นรูปแบบการวิจัยเชิงปริมาณ ใช้แบบแบบสอบถามเป็นเครื่องมือการวิจัย กลุ่มตัวอย่างที่ใช้ในการวิจัย คือ ประชาชนผู้มีงานทำในจังหวัดสุพรรณบุรี จำนวน 400 คน โดยใช้การสุ่มตัวอย่างแบบไม่อาศัยความน่าจะเป็นด้วยวิธีแบบบังเอิญ สถิติที่ใช้ในการวิเคราะห์ คือ ค่าสัมประสิทธิ์ถดถอยพหุคูณแบบขั้นตอน ผลการวิจัยพบว่า ปัจจัยที่สามารถพยากรณ์การปรับตัวด้านการเงินของประชาชนในจังหวัดสุพรรณบุรีภายใต้สถานการณ์การแพร่ระบาดของโรคติดเชื้อไวรัสโคโรนา 2019 ได้แก่ มาตรการเยียวยาด้านการเงินจากภาครัฐ (X4) ทัศนคติต่อการบริหารการเงิน (X1) อิทธิพลจากกลุ่มอ้างอิง (X3) และความรับผิดชอบต่อการเงินครอบครัว (X2) โดยมีค่าอำนาจการพยากรณ์ร้อยละ 69.00 มีความคลาดเคลื่อนมาตรฐานของการพยากรณ์ .302 มีค่าสัมประสิทธิ์ของตัวพยากรณ์ในรูปคะแนนดิบ (b) เท่ากับ .469, 399, .377 และ -.351 และมีค่าสัมประสิทธิ์ของตัวพยากรณ์ในรูปคะแนนมาตรฐาน (β) เท่ากับ .448, 431, .317 และ -.272 ตามลำดับ ค่าคงที่ของสมการพยากรณ์ในรูปแบบของคะแนนดิบเท่ากับ .599 ซึ่งสามารถนำมาสร้างเป็นสมการพยากรณ์การปรับตัวด้านการเงินของประชาชนในจังหวัดสุพรรณบุรีภายใต้สถานการณ์การแพร่ระบาดของโรคติดเชื้อไวรัสโคโรนา 2019 ได้ดังนี้
สมการพยากรณ์ในรูปคะแนนดิบ
Y = .599 + .469 X4 + .399 X1 + .377 X3 - .351 X2
สมการพยากรณ์ในรูปคะแนนมาตรฐาน
Z = .448 X4 + .431 X1 + .317 X3 - .272 X2
Ngôn Sứ Như Là Điềm Báo - Phân Tích Ê-Dê-Ki-En 24:15-24
Authors: Phạm Trọng 
Published: July 2023

Trung thành sống căn tính ngôn sứ của mình là lời mời gọi không ngừng đối với mỗi Kitô hữu. Tuy nhiên, để sống đúng căn tính ngôn sứ không phải lúc nào cũng dễ dàng, đặc biệt là khi phải đối diện với những nghịch cảnh của cuộc sống. Bài phân tích điềm báo của ngôn sứ Ê-dê-ki-en trong Êd 24: 15-24 là một nổ lực của tác giả nhằm phác họa hình ảnh về vị ngôn sứ luôn trung thành với sứ mạng của mình dẫu phải đối diện với muôn vàn nghịch cảnh, hầu có thể mưu ích cho cộng đồng mình được sai đến. Trong bài viết này, tác giả lần lượt trình bày bối cảnh lịch sử, xã hội, thời điểm, nơi chốn mà ngôn sứ Ê-dê-ki-en thực thi sứ mạng của mình. Kế đến là những phân tích bản văn và đưa ra ý nghĩa của hành động ngôn sứ mà Ê-dê-ki-en thực hiện cho dân. Từ đó, tác giả rút ra những bài học giúp người Kitô hữu ngày nay có thể noi gương Ê-dê-ki-en sống trung thành với căn tính ngôn sứ của mình.

Abstract
Living Faithfully to One's Prophetic Calling is a Constant Invitation for Every Christian. However, living in accordance with one's prophetic calling is not always easy, especially when facing the adversities of life. The analysis of the prophecy of the prophet Ezekiel in Ezekiel 24:15-24 is an effort by the author to depict an image of a prophet who remains faithful to his mission despite encountering numerous challenges, in order to benefit his community. In this article, the author sequentially presents the historical, social, temporal, and geographical contexts in which the prophet Ezekiel carried out his mission. Following that, there are analyses of the text and an exploration of the significance of the prophet Ezekiel's actions for the people. From these insights, the author draws lessons to help contemporary Christians emulate Ezekiel's faithful living in accordance with their prophetic calling.
3D wildlife skull models for wildlife veterinary training
Authors: Rocha‐Martínez Nadia , López‐Ordaz Reyes , Rendón‐Franco Emilio , Muñoz‐García Claudia I. 
Published: July 2023

AbstractWildlife veterinarians are necessary for zoonotic diseases and species loss management, and there is a rising interest to enroll at veterinary schools with the wish to work in zoo and wildlife medicine. However, teaching wildlife is challenging due to the difficulty faced by universities to work with wild animal specimens. The aim of the present was to evaluate the understanding efficiency of some anatomical and behavioral aspects using 3D printed models of four wildlife species skulls, the kinkaju (Potos flavus), the white‐nosed coati (Nasua narica), the northern anteater (Tamandua mexicana), and the nine‐banded armadillo (Dasypus novemcinctus). This study was performed on 85 third‐year veterinary students, divided into an experimental and a control group, who used and not used 3D printed skulls, respectively. Results show that the experimental group shows higher scores, in three of the four variables evaluated, than the control group. Then, 3D wildlife printed skulls constitute a promising teaching tool for veterinary students. In fact, it may be as good as real skulls, since new 3D printers can print on high endurance and firmness stock with high accuracy at reduced costs. In this context, it is important to encourage its use for the training of new generations and keep professionals up to date.
In vitro acne disease model from inertial focusing effect for studying the interactions between sebocyte glands and macrophages
Authors: Tang Tan , Xu Ye , Wang Lelin , Zhang Peipei 
Published: July 2023

AbstractAcne is one of the most widespread skin diseases. The acne mechanism is intricate, involving interactions between different types of cells (i.e., sebocytes and macrophages). One of the challenges in studying the mechanism of acne is that current in vitro culture methods cannot reflect the 3D cellular environment in the tissue, including inflammatory stimuli and cellular interactions especially the interactions between sebocytes and immune cells. To solve this issue, we generated an in vitro acne disease model consisting of 3D artificial sebocyte glands and macrophages through the inertial focusing effect method. Using this model, we produced a controllable inflammatory environment similar to the acne pathogenetic process in the skin. The 3D artificial sebocyte glands and macrophages can be separated for analyzing each cell type, assisting the in‐depth understanding of the acne mechanism. This study indicates that proinflammatory macrophages promote lipid accumulation and induce oxidative stress in sebocyte glands. Additionally, in an inflammatory environment, sebocyte glands induce macrophage polarization into the M1 phenotype. Employing this model for drug screening, we also demonstrated that, cannabidiol (CBD), a clinically investigated drug, is effective in restoring lipid accumulation, oxidative stress, inflammatory cytokines and macrophage polarization in the acne disease.
Organization of orbitofrontal‐auditory pathways in the Mongolian gerbil
Authors: Ying Rose , Hamlette Lashaka , Nikoobakht Laudan , Balaji Rakshita , Miko Nicole , Caras Melissa L. 
Published: July 2023

AbstractSound perception is highly malleable, rapidly adjusting to the acoustic environment and behavioral demands. This flexibility is the result of ongoing changes in auditory cortical activity driven by fluctuations in attention, arousal, or prior expectations. Recent work suggests that the orbitofrontal cortex (OFC) may mediate some of these rapid changes, but the anatomical connections between the OFC and the auditory system are not well characterized. Here, we used virally mediated fluorescent tracers to map the projection from OFC to the auditory midbrain, thalamus, and cortex in a classic animal model for auditory research, the Mongolian gerbil (Meriones unguiculatus). We observed no connectivity between the OFC and the auditory midbrain, and an extremely sparse connection between the dorsolateral OFC and higher order auditory thalamic regions. In contrast, we observed a robust connection between the ventral and medial subdivisions of the OFC and the auditory cortex, with a clear bias for secondary auditory cortical regions. OFC axon terminals were found in all auditory cortical lamina but were significantly more concentrated in the infragranular layers. Tissue‐clearing and lightsheet microscopy further revealed that auditory cortical‐projecting OFC neurons send extensive axon collaterals throughout the brain, targeting both sensory and non‐sensory regions involved in learning, decision‐making, and memory. These findings provide a more detailed map of orbitofrontal‐auditory connections and shed light on the possible role of the OFC in supporting auditory cognition.
Bayesian functional emulation of CO2 emissions on future climate change scenarios
Authors: Aiello Luca , Fontana Matteo , Guglielmi Alessandra 
Published: July 2023

AbstractWe propose a statistical emulator for a climate‐economy deterministic integrated assessment model ensemble, based on a functional regression framework. Inference on the unknown parameters is carried out through a mixed effects hierarchical model using a fully Bayesian framework with a prior distribution on the vector of all parameters. We also suggest an autoregressive parameterization of the covariance matrix of the error, with matching marginal prior. In this way, we allow for a functional framework for the discretized output of the simulators that allows their time continuous evaluation.
No Effect of NSAID Use on Efficacy of Zoledronate: A Post Hoc Analysis of a Randomized Trial in Osteopenic Older Women
Authors: Reid Ian R , Horne Anne M , Mihov Borislav , Bastin Sonja , Gamble Gregory D 
Published: July 2023

ABSTRACT
Bisphosphonates are widely used for the prevention and treatment of osteoporosis. Nonsteroidal anti-inflammatory drugs (NSAIDs) are also widely used among the older population group at high risk of fractures. NSAIDs have been shown to impact on bone turnover, and a recent reanalysis of a clinical trial of clodronate found that NSAID use at baseline abrogated any effect of clodronate on either bone density (BMD) or fracture risk. To determine whether NSAIDs influence the efficacy of other bisphosphonates, we have reanalyzed our 6-year randomized controlled trial of zoledronate in 2000 osteopenic postmenopausal women. NSAID use was reported at baseline in 38% of the cohort and anytime use was reported by 65%. The evolution of the zoledronate effects on BMD were almost identical whether or not women were using NSAIDs at baseline and were significant in both subgroups at all BMD sites (p &lt; 0.0001). The significant reduction in the risk of fracture in those allocated to zoledronate (p &lt; 0.0001) showed no interaction with baseline use of NSAIDs (p = 0.33) nor with NSAID use at any time during the study (p = 0.28). The odds of fracture were significantly reduced in both NSAID users and nonusers. We conclude that the present analysis provides no support for the suggestion that NSAIDs interfere with the efficacy of potent bisphosphonates in terms of their effects on bone density or fracture. © 2023 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research (ASBMR).
Response to substance use during hospitalization: A survey study of current and ideal policies and practices
Authors: Huxley‐Reicher Zina , Puglisi Lisa B. , Tetrault Jeanette M. , Weimer Melissa B. , Stellini Meg , Bhandary‐Alexander James , Thomas Kathryn A. , Donroe Joseph H. 
Published: July 2023

AbstractPeople may use nonprescribed substances during an acute hospitalization. Hospital policies and responses can be stigmatizing, involve law enforcement, and lead to worse patient outcomes, including patient‐directed discharge. In the United States, there is currently little data on hospital policies that address the use of substances during hospitalization. In this cross‐sectional study, we surveyed clinicians at US hospitals with Accreditation Council of Graduate Medical Education (ACGME)‐accredited addiction medicine fellowships about their current practices and policies and what they would include in an ideal policy. We had 77 responses from 55 out of 86 ACGME‐addiction medicine fellowships (63.9%). Respondents identified policies at 21.8% of the institutions surveyed. Current responses to inpatient substance use vary, though most do not match what clinicians identify as an ideal response. Our results suggest that the use of nonprescribed substances during a hospitalization may be common, but a majority of hospitals likely do not have patient‐centered policies to address this.
A categorical equivalence between logical quantale modules and quantum B‐modules
Authors: Ruan Xianglong , Liu Xiaochuan 
Published: July 2023

AbstractThis paper introduces the notion of logical quantale module. It proves that there is a dual equivalence between the category of logical quantale modules and the category of quantum B‐modules, in the way that every quantum B‐module admits a natural embedding into a logical quantale module, the enveloping quantale module.
11q13.3q13.4 deletion plus 9q21.13q21.33 duplication in an affected girl arising from a familial four‐way balanced chromosomal translocation
Authors: Zhang Qinxin , Wang Yan , Zhou Jing , Zhou Ran , Liu An , Meng Lulu , Ji Xiuqing , Hu Ping , Xu Zhengfeng 
Published: July 2023

AbstractBackgroundWe describe a 13‐year‐old girl with a 11q13.3q13.4 deletion encompassing the SHANK2 gene and a 9q21.13q21.33 duplication. She presented with pre‐ and postnatal growth retardation, global developmental delay, severe language delay, cardiac abnormalities, and dysmorphisms. Her maternal family members all had histories of reproductive problems.MethodsMaternal family members with histories of reproductive problems were studied using G‐banded karyotyping and optical genome mapping (OGM). Long‐range PCR (LR‐PCR) and Sanger sequencing were used to confirm the precise break point sequences obtained by OGM.ResultsG‐banded karyotyping characterized the cytogenetic results as 46,XX,der(9)?del(9)(q21q22)t(9;14)(q22;q24),der(11)ins(11;?9)(q13;?q21q22),der(14)t(9;14). Using OGM, we determined that asymptomatic female family members with reproductive problems were carriers of a four‐way balanced chromosome translocation. Their karyotype results were further refined as 46,XX,der(9)del(9)(q21.13q21.33)t(9;14)(q21.33;q22.31),der(11)del(11)(q13.3q13.4)ins(11;9)(q13.3;q21.33q21.13),der(14)t(9:14)ins(14;11)(q23.1;q13.4q13.3). Thus, we confirmed that the affected girl inherited the maternally derived chromosome 11. Furthermore, using LR‐PCR, we showed that three disease‐related genes (TMC1, NTRK2, and KIAA0586) were disrupted by the breakpoints.ConclusionsOur case highlights the importance of timely parental origin testing for patients with rare copy number variations, as well as the accurate characterization of balanced chromosomal rearrangements in families with reproductive problems. In addition, our case demonstrates that OGM is a useful clinical application for analyzing complex structural variations within the human genome.
De novo drug design based on patient gene expression profiles via deep learning
Authors: Yamanaka Chikashige , Uki Shunya , Kaitoh Kazuma , Iwata Michio , Yamanishi Yoshihiro 
Published: July 2023

AbstractComputational de novo drug design is a challenging issue in medicine, and it is desirable to consider all of the relevant information of the biological systems in a disease state. Here, we propose a novel computational method to generate drug candidate molecular structures from patient gene expression profiles via deep learning, which we call DRAGONET. Our model can generate new molecules that are likely to counteract disease‐specific gene expression patterns in patients, which is made possible by exploring the latent space constructed by a transformer‐based variational autoencoder and integrating the substructures of disease‐correlated molecules. We applied DRAGONET to generate drug candidate molecules for gastric cancer, atopic dermatitis, and Alzheimer's disease, and demonstrated that the newly generated molecules were chemically similar to registered drugs for each disease. This approach is applicable to diseases with unknown therapeutic target proteins and will make a significant contribution to the field of precision medicine.
Enteral feeding tolerance during pharmacologic neuromuscular blockade
Authors: Dickerson Roland N. , Farrar Julie E. , Byerly Saskya , Filiberto Dina M. 
Published: July 2023

AbstractA common misperception is that critically ill patients who receive paralytic therapy will not tolerate enteral nutrition. As a result, some clinicians empirically withhold enteral feedings for critically ill patients who receive neuromuscular blocker pharmacotherapy (NMB). The intent of this review is to examine the evidence regarding enteral feeding tolerance for critically ill patients given NMB. Studies evaluating enteral feeding during paralytic therapy are provided and critiqued. Evidence examining enteral feeding tolerance during NMB is limited. Enteral feeding intolerance is more likely attributable to the underlying illnesses and concurrent opioid analgesia, sedation, and vasopressor therapies. Most critically ill patients can be successfully fed during NMB. Prokinetic pharmacotherapy may be warranted in some patients.
The stories of four more process safety legends
Authors: Murphy John , Willey Ronald J. , Baulch Arthur 
Published: July 2023

AbstractThis is the second group of process safety legends that have been selected by the editors of Process Safety Progress (PSP). The first group of process safety legends was reported on in the March 2021 edition of PSP. At that time, the Editorial Board of PSP recommended an article in the journal be dedicated to process safety legends to inspire others working in the field. The editors of PSP decided to continue this recognition of process safety excellence. This second article on process safety legends summarizes the careers of John Herber, Kathy Kas, Louisa Nara, and Ron Willey. Combined they represent 176 years of process safety practice.
Diurnal variations of the meridional overturning circulations over West Africa during the premonsoon and monsoon seasons
Authors: Huaman Lidia , Schumacher Courtney , Fink Andreas H. , Buttitta Erin 
Published: July 2023

AbstractDiurnal variations in the shallow and deep meridional overturning over West Africa during the premonsoon (April–May) and monsoon (July–September) seasons were analyzed using ECMWF Reanalysis 5th Generation (ERA5) reanalysis and Tropical Rainfall Measuring Mission (TRMM)/Global Precipitation Measurement (GPM) satellite radar data from 1998 to 2019. We found that a daytime sea breeze and two nocturnal low‐level jets have varying impacts on the diurnal cycle of convection and the meridional circulations over West Africa, depending on the season. During the premonsoon, the zonal rain belt is centered over the Gulf of Guinea and the sea breeze initiates intense deep convection (and thus deep overturning) over the coastal region in the afternoon that propagates northward into the early evening. The nocturnal Sahel/Sahara low‐level jet (SLLJ) then drives low‐level convergence into the West African heat low, producing a strong, dry shallow overturning over land at night. During the monsoon, the rain belt is centered over land (N) and the sea breeze is forced by weaker temperature gradients, producing less intense convection that does not propagate as far inland as during the premonsoon. However, organized convection inland maintains deep daytime overturning. At night, a coastal low‐level jet strengthens northward moisture transport from the Gulf of Guinea into the active monsoon region after the sea breeze dissipates, helping maintain convective systems with large stratiform components and continued deep meridional overturning over land. The nocturnal SLLJ still drives low‐level convergence into the West African heat low, but the dry shallow meridional overturning is farther north and weaker than in the premonsoon. While ERA5 winds and moisture‐flux convergence are generally consistent with diurnal variations in the TRMM/GPM
precipitation, ERA5 precipitation is not. The reanalysis indicates significant biases in the timing and magnitude of rainfall over the Gulf of Guinea and West Africa in each season, with the convective and large‐scale rain fields both contributing to the disparate precipitation patterns.
Analysis of spatially coherent forecast error structures
Authors: Gupta Shraddha , Banerjee Abhirup , Marwan Norbert , Richardson David , Magnusson Linus , Kurths Jürgen , Pappenberger Florian 
Published: July 2023

AbstractUnderstanding error properties is an essential part in numerical weather prediction. Predictable relationship between errors of different regions due to some underlying systematic or random process can give rise to correlated errors. Estimation of error correlation is crucial for improvement of forecasts. However, the size of the corresponding correlation matrix is larger than what is possible to represent on geographical maps in order to diagnose its full spatial variation. Here, we propose a complex network‐based approach to analyse forecast error correlations that enables us to estimate the spatially varying component of the error. A quantitative study of the spatio‐temporal coherent structures of medium‐range forecast errors of different climate variables using network measures can reveal common sources of errors. Such information is crucial, especially in cases such as the outgoing long‐wave radiation, in which errors are correlated across very long distances, indicating an underlying climate mechanism as the source of the error. We show that the spatial patterns of forecast error co‐variability may not be the same as that of the corresponding climate variable itself, thereby implying that the mechanisms behind the correlated errors may be different from the climate processes responsible for the spatio‐temporal interactions of the climate variable. Our results highlight the importance of diagnosing the full spatial variation of error correlations to understand the origin and propagation of forecast errors, and demonstrate complex networks to be a promising diagnostic tool in this regard.