bluuebunny/crossref_metadata_2025_split huggingface dataset:
Patterns of childhood maltreatment influence sleep quality: The role of emotion regulation
Authors: Liu Sihan , Ahemaitijiang Nigela , Xu Jianjie , Liu Yang , Chen Lu , Han Zhuo Rachel 
Published: June 2023

AbstractChildhood maltreatment exerts long-term consequences on sleep health, and different subtypes could constitute maltreatment patterns. However, how naturally occurring patterns of childhood maltreatment affect subsequent sleep quality and the underlying mechanisms remain relatively unclear, particularly in youths undergoing a transitional period and in the Chinese cultural context. In this study, we identified childhood maltreatment patterns and explored how these patterns predicted sleep problems through differential emotion regulation strategies. We tracked 1929 Chinese youths (Mage = 18.49; 63.1% females) for one year. Three latent profiles were identified: low maltreatment exposure, high physical and emotional maltreatment, and high sexual abuse. Compared with “low maltreatment exposure,” youths in “high physical and emotional maltreatment” used fewer cognitive reappraisal strategies, and those in “high sexual abuse” used more expressive suppression, and then leading to more sleep problems. This study reveals new insights into the patterns of childhood maltreatment in Chinese youths and implies that individuals exposed to sexual abuse or a combination of physical and emotional maltreatment experience sleep problems through the impairment of differential emotion regulation processes. It also highlights the necessity of setting differential targets on emotion regulation strategies for distinct groups of maltreatment and considering the co-occurrence of physical and emotional maltreatment.
Caregiver perceptions of nutrition interventions in infants and children under 24 months of age: a systematic review
Authors: Stelle Isabella , Kinshella Mai-Lei Woo , Moore Sophie E 
Published: June 2023

AbstractObjective:Efficacy studies show early nutrition interventions improving infant nutrition status, but understanding caregiver acceptability is required for implementation of such interventions. This systematic review examines caregivers’ perceptions of nutrition interventions in young children.Design:We searched the Cochrane Central Register of Controlled Trials, MEDLINE, Embase, CINAHL and PsychINFO from date of online journal inception through December 2020. Interventions included oral (powder/liquid/tablet) and/or intravenous supplementation, food fortification and nutrition counselling. Inclusion criteria included primary research, data presented on caregiver perception and studies published in English. Quality assessment was performed using the Critical Appraisal Skills Programme tool. Studies underwent narrative synthesis using inductive thematic analysis.Setting:No restriction.Participants:Caregivers of children under 24 months of age.Results:Of 11 798 records identified, thirty-seven publications were included. Interventions included oral supplementation, food fortification and nutrition counselling. Caregivers included mothers (83 %), fathers, grandparents and aunts. Perceptions were gathered through individual interviews, focus group discussions, questionnaires, surveys and ratings. Totally, 89 % of studies noted high acceptability (n 33 most notably increased appetite (n 17). In total, 57 % of studies (n 21) cited low acceptability, commonly from side effects (n 13) such as gastrointestinal issues, appetite loss and stained teeth.Conclusions:Positive perceptions and enthusiasm for interventions were frequently reported. Key to implementation was the increased appetite noted by caregivers. A substantial proportion of studies reported negative perceptions, mainly due to side effects. In future interventions, mitigation and education around common side effects are crucial for acceptability. Understanding both positive and negative caregiver perceptions is important for informing future nutrition interventions and strengthening sustainability and implementation.
Normative Foundations of Kant’s Cosmopolitan Right: The Overlooked Legacy of Kant’s Metaphysics of Nature
Authors: Massimi Michela 
Published: June 2023

AbstractKant’s philosophy of natural science has traditionally concentrated on a host of issues including the role of laws of nature and teleological judgements. However, so far, the literature has made virtually no contact with the no less important tradition in Kant’s legal and political philosophy. This article explores one aspect of such connection in relation to the normative foundations of Kant’s notion of cosmopolitan right. I argue that Kant’s argument for cosmopolitan right is based on two main premises: the first is what I call thelaw of equilibrium, and the second is thepremise of physical interaction(commerciumin Latin) at work behind what Kant called the original ‘community of land’. The article argues that the relevant notion of community quacommerciumshould be understood in the context of Kant’s metaphysics of nature as a ‘real community of substances’ governed by a dynamical law of equality of action and reaction. This metaphysical-causal interpretive reading has far-reaching implications for the foundations of cosmopolitan right and its scope of applicability well beyond Kant’s envisaged right to universal hospitality.
Patient-reported outcome measurement in palliative care: A hermeneutic narrative review
Authors: Collier Aileen , Spruijt Odette , Minton Ollie , Broom Alex 
Published: June 2023

AbstractObjectivesRecent years have witnessed the rise of patient-reported outcome measures (PROMs) in palliative care (PC), particularly those focused on the standardized measurement of symptom burden. These measures seek to evaluate the quality of PC through the quantification of various aspects of potential suffering (e.g., sleeplessness, loss of appetite, and pain). Further, drawing on patient experience, they provide a framework for evaluating the effectiveness of, and at times expanding, PC services. The aim of this paper is to provide a theoretically informed normative critique of PROMS-PC through a critical engagement with heterogeneous literatures.MethodsA hermeneutic narrative review underpinned by a view of “knowing” as an ongoing social accomplishment and inspired by complexity theory.ResultsThis narrative review highlights some limitations to the development of PROMs, including the use of proxies to complete them, and how the outcomes may not always reflect either the character of PC or the key aspects of practice and experience therein.Significance of resultsIn their current form, PROMs have the potential to skew understandings of service quality, for example, by privileging one aspect of quality, that is, physical symptoms over other aspects of quality such as communication with care providers.
Naldemedine-induced opioid withdrawal with restlessness as the predominant symptom in a palliative care setting
Authors: Sato Ryota , Ishida Mayumi , Uchida Nozomu , Sakimoto Takehiko , Yamaguchi Takefumi , Ooya Yoshitaka , Takahashi Takao , Onishi Hideki 
Published: June 2023

AbstractObjectivesOpioid analgesics play a central role in cancer pain treatment; however, it has been reported that opioid-induced constipation (OIC) develops in 80% of patients using opioid analgesics and leads to a decrease in quality of life. Naldemedine improves constipation without affecting the analgesic action of opioid analgesics via peripheral μ-opioid receptors.MethodsWe report a terminally ill cancer patient who was diagnosed with opioid withdrawal syndrome (OWS) based on symptoms centered around restlessness and sweating that developed 43 days after administration of naldemedine for OIC.ResultsThe patient was a 78-year-old woman who was diagnosed with stage IVB uterine sarcoma in October, 1 year prior to her visit to our clinic, and underwent chemotherapy after surgery, but the disease became progressive. Thereafter, metastasis to the fourth thoracic vertebrae (Th4) was identified, and loxoprofen and acetaminophen were started for pain at the metastatic site. Oxycodone hydrochloride hydrate 10 mg/day was additionally administered on postoperative day 11, followed by naldemedine 0.2 mg/day for OIC. On the 43rd day after administration, the patient began to wander the hospital ward in a wheelchair and became noticeably restless. OWS due to naldemedine administration was suspected, and naldemedine was discontinued. The symptoms improved 7 days later, and no similar symptoms were observed thereafter.Significance of resultsPatients receiving palliative care often exhibit psychiatric symptoms such as anxiety and depression, but OWS due to naldemedine should also be considered as a potential cause.
Strip cropping in organically managed vegetable systems: agronomic and environmental effects
Authors: Campanelli Gabriele , Iocola Ileana , Leteo Fabrizio , Montemurro Francesco , Platani Cristiano , Testani Elena , Canali Stefano 
Published: June 2023

Abstract
This study evaluated the agro-environmental and economic effectiveness of strips introduced in a diversified organic vegetable system. Two experiments of three experimental years (2018, 2019, 2020) were carried out within the 4-year rotation of MOnsampolo VEgetable organic Long-Term Experiment (MOVE LTE) in Central Italy to test strip cropping vs pure stand. The crop combinations in the two experiments were faba bean (Vicia faba L.)–tomato (Solanum Lycopersicum L.) and common wheat (Triticum aestivum)–zucchini (Cucurbita pepo L.). We determined the productive and economic performances, disease and weed control, nutritional differences and effectiveness in returning carbon to the soil. The two strip cropping systems allowed a better use of resources, enhancing plant biomass and crop residues, particularly for tomato (+24%) and zucchini (+63%). However, the greater plant biomass did not always result in an increase in crop yields. For example, while the wheat–zucchini strip system showed a land equivalent ratio >1 in all three experimental years with a high yield performance in zucchini (+54% of yield), the faba bean–tomato system was more productive in strips only in 2018. On the contrary, this latter system contributed a carbon return >1 in all three experimental years. No significant differences between strip and pure stand systems were observed for fusarium (Fusarium oxysporum f. sp. lycopersici) and oidium (Oidium spp.) diseases on tomato and zucchini crops, respectively, and for weed control. Lastly, greater labor costs associated in both experiments did not affect their profitability (+21% and +319% in faba bean–tomato and wheat–zucchini experiments, respectively). Overall, our findings pointed out that farmers could increase sustainability of their cropping systems with the introduction of a well-designed strip cropping system, which can lead to the reduction of economic risks, greater potential soil carbon and more efficient use of resources on the same land.
FINITE AXIOMATIZABILITY OF TRANSITIVE MODAL LOGICS OF FINITE DEPTH AND WIDTH WITH RESPECT TO PROPER-SUCCESSOR-EQUIVALENCE
Authors: ZHANG YAN , XU MING 
Published: June 2023

AbstractThis paper proves the finite axiomatizability of transitive modal logics of finite depth and finite width w.r.t. proper-successor-equivalence. The frame condition of the latter requires, in a rooted transitive frame, a finite upper bound of cardinality for antichains of points with different sets of proper successors. The result generalizes Rybakov’s result of the finite axiomatizability of extensions of
$\mathbf {S4}$
of finite depth and finite width.
Separating the General and Content-Specific Components of Self-Reported Propensity for Mind-Wandering
Authors: Kowalczyk Marek , Klonowska Magdalena , Mikietyńska Agata 
Published: June 2023

Abstract: People differ in the propensity to mind-wander, that is, the tendency to slip into thinking about something else than the task at hand or the happenings in the immediate environment. Research indicates that mind-wandering tends to be associated with negative emotional states and that it declines with increasing age in adulthood. A question arises whether these relationships are true of mind-wandering in general, independently of its content and affective tone, or just particular kinds of off-task thinking. Participants ( N = 218) aged 18–84 years filled out the Task-Unrelated Thoughts Questionnaire (TUTQ), a multidimensional instrument for measuring individual tendencies in mind-wandering, and several scales related to affective functioning. A bifactor model for the TUTQ was employed, encompassing a general factor and three orthogonal specific factors that referred to affectively different modes of off-task thinking. The scores on the general factor decreased with increasing age of the respondents, dispositional positive affect, and satisfaction with life, whereas they increased with increasing negative affect and emotional reactivity. Age and affect-related variables, including individual tendencies in emotion regulation, also predicted, selectively, the specific factors. Although methodologically and theoretically challenging, the bifactor model seems to be a promising tool for representing and exploring individual variability in mind-wandering.
Atmospherically Driven Seasonal and Interannual Variability in the Lagrangian Transport Time Scales of a Multiple‐Inlet Coastal System
Authors: Fajardo‐Urbina Jeancarlo M. , Arts Gijs , Gräwe Ulf , Clercx Herman J. H. , Gerkema Theo , Duran‐Matute Matias 
Published: June 2023

AbstractIntense short‐term wind events can flush multiple‐inlet systems and even renew the water entirely. Nonetheless, little is known about the effect of wind variations at seasonal and interannual scales on the flushing of such systems. Here, we computed two Lagrangian transport time scales (LTTS), the residence and exposure times, for a multiple‐inlet system (the Dutch Wadden Sea) over 36 years using a realistic numerical model simulation. Our results reveal pronounced seasonal and interannual variability in both system‐wide LTTS. The seasonality of the LTTS is strongly anti‐correlated to the wind energy from the prevailing directions, which are from the southwesterly quadrant and coincidentally aligned with the geographical orientation of the system. This wind energy, which is stronger in autumn‐winter than in spring‐summer, triggers strong flushing (and hence low values of the LTTS) during autumn‐winter. The North Atlantic Oscillation (NAO) and the Scandinavia Pattern (SCAN) are shown to be the main drivers of interannual variability in the local wind and, ultimately, in both LTTS. However, this coupling is much more efficient during autumn‐winter when these patterns show larger values and variations. During these seasons, a positive NAO and a negative SCAN induce stronger winds in the prevailing directions, enhancing the flushing efficiency of the system. The opposite happens during positive SCAN and negative NAO, when weaker flushing during autumn‐winter is observed. Thus, large‐scale atmospheric patterns strongly affect the interannual variability in flushing and are potential drivers of the long‐term ecology and functioning of multiple‐inlet systems.
Alprazolam modulates persistence energy during emotion processing in first-degree relatives of individuals with schizophrenia: a network control study
Authors: Mahadevan Arun S. , Cornblath Eli J. , Lydon-Staley David M. , Zhou Dale , Parkes Linden , Larsen Bart , Adebimpe Azeez , Kahn Ari E. , Gur Ruben C. , Gur Raquel E. , Satterthwaite Theodore D. , Wolf Daniel H. , Bassett Dani S. 
Published: June 2023

AbstractSchizophrenia is marked by deficits in facial affect processing associated with abnormalities in GABAergic circuitry, deficits also found in first-degree relatives. Facial affect processing involves a distributed network of brain regions including limbic regions like amygdala and visual processing areas like fusiform cortex. Pharmacological modulation of GABAergic circuitry using benzodiazepines like alprazolam can be useful for studying this facial affect processing network and associated GABAergic abnormalities in schizophrenia. Here, we use pharmacological modulation and computational modeling to study the contribution of GABAergic abnormalities toward emotion processing deficits in schizophrenia. Specifically, we apply principles from network control theory to model persistence energy – the control energy required to maintain brain activation states – during emotion identification and recall tasks, with and without administration of alprazolam, in a sample of first-degree relatives and healthy controls. Here, persistence energy quantifies the magnitude of theoretical external inputs during the task. We find that alprazolam increases persistence energy in relatives but not in controls during threatening face processing, suggesting a compensatory mechanism given the relative absence of behavioral abnormalities in this sample of unaffected relatives. Further, we demonstrate that regions in the fusiform and occipital cortices are important for facilitating state transitions during facial affect processing. Finally, we uncover spatial relationships (i) between regional variation in differential control energy (alprazolam versus placebo) and (ii) both serotonin and dopamine neurotransmitter systems, indicating that alprazolam may exert its effects by altering neuromodulatory systems. Together, these findings provide a new perspective on the distributed emotion processing network and the effect of GABAergic modulation on this network, in addition to identifying an association between schizophrenia risk and abnormal GABAergic effects on persistence energy during threat processing.
The Southern European Atlantic diet and depression risk: a European multicohort study
Authors: Carballo-Casla Adrián , Stefler Denes , Ortolá Rosario , Chen Yuntao , Knuppel Anika , Ruiz Milagros , Kozela Magdalena , Kubinova Ruzena , Pajak Andrzej , Rodríguez-Artalejo Fernando , Brunner Eric J. , Bobak Martin 
Published: June 2023

AbstractThe Southern European Atlantic diet (SEAD) is the traditional dietary pattern of north-western Spain and northern Portugal, but it may resemble that of other European countries. The SEAD has been found associated with lower risk for myocardial infarction and mortality. Since dietary patterns may also influence mental health, we examined the association between the SEAD and depression risk in southern, central, eastern, and western European populations. We conducted a prospective analysis of five cohorts (13,297 participants aged 45–92 years, free of depression at baseline): Seniors-ENRICA-1 and Seniors-ENRICA-2 (Spain), HAPIEE (Czechia and Poland), and Whitehall-II (United Kingdom). The SEAD comprised cod, other fresh fish, red meat and pork products, dairy, legumes and vegetables, vegetable soup, potatoes, whole-grain bread, and moderate wine consumption. Depression at follow-up was defined according to presence of depressive symptoms (based on available scales), use of prescribed antidepressants, inpatient admissions, or self-reported diagnosis. Associations were adjusted for sociodemographic, lifestyle, and dietary variables. During a median follow-up of 3.9 years (interquartile range 3.4–4.9), there were 1437 new depression cases. Higher adherence to the SEAD was associated with lower depression risk in the pooled sample. Individual food groups showed a similar tendency, albeit non-significant. The fully adjusted odds ratio (95% confidence interval) per 1-standard deviation increment in the SEAD was 0.91 (0.86, 0.96). This association was rather consistent across countries [Spain = 0.86 (0.75, 0.99), Czechia = 0.86 (0.75, 0.99), Poland = 0.97 (0.89, 1.06), United Kingdom = 0.85 (0.75, 0.97); p for interaction = 0.24], and was of similar magnitude as that found for existing healthy dietary patterns. In conclusion, the SEAD was associated with lower depression risk across European populations. This may support the development of mood disorder guidelines for Southern European Atlantic regions based on their traditional diet, and for central, eastern, and western European populations based on the SEAD food groups that are culturally rooted in these places.
Antidepressant treatment in pregnancy: a Danish registry linkage study in pregnant women with pre-existing obsessive‐compulsive disorder
Authors: Trinh Nhung T. H. , Semark Birgitte Dige , Munk-Olsen Trine , Liu Xiaoqin , Thapa Suraj Bahadur , Yilmaz Zeynep , Petersen Liselotte Vogdrup , Lupattelli Angela 
Published: June 2023

AbstractThe association between antidepressant continuation during pregnancy and postpartum mental health in women with obsessive-compulsive disorder (OCD) is uncertain. We identified 1317 women with live-birth singleton pregnancies and having outpatient/inpatient visits for OCD in the 4 years pre-pregnancy from the Danish registries. We defined three groups based on antidepressant prescriptions filled in the 2 years before pregnancy to delivery: (i) unexposed (n = 449); (ii) discontinuers (n = 346), i.e., with pre-pregnancy antidepressant fills only; (iii) continuers (n = 522), i.e., with antidepressant fills before and during pregnancy. We estimated crude and propensity score weighted hazard ratio (HRs) of postpartum visit for OCD and mood/anxiety disorders using Cox proportional hazard models. In weighted analyses, we found no difference in the probability of a postpartum visit for OCD or MADs with antidepressant continuation compared to unexposed and discontinuers. The likelihood of a postpartum OCD visit was higher in pregnancies having only one prescription fill during pregnancy compared to unexposed (HR = 3.44, 95% CI: 1.24, 9.54) or discontinuers (HR = 2.49, 95% CI: 0.91, 6.83). Continuers in pregnancy without antidepressant fill in the first three months postpartum had higher probability for postpartum visit for mood/anxiety disorders compared to discontinuers (HR = 3.84, 95% CI: 1.49, 9.92). Among pregnant women with pre-existing OCD, we found similar probabilities of a postpartum visit for OCD or mood/anxiety disorders in antidepressant continuers compared to unexposed and discontinuers. Continuers with a single prescription fill during pregnancy or no fill postpartum may have higher risks for these outcomes. Our findings highlight the importance of continuity of treatment throughout the perinatal period.
Extracellular vesicle-associated IGF2BP3 tunes Ewing sarcoma cell migration and affects PI3K/Akt pathway in neighboring cells
Authors: Mancarella Caterina , Giusti Veronica , Caldoni Giulia , Laginestra Maria Antonella , Parra Alessandro , Toracchio Lisa , Giordano Giorgia , Roncuzzi Laura , Piazzi Manuela , Blalock William , Columbaro Marta , De Feo Alessandra , Scotlandi Katia 
Published: June 2023

AbstractEwing sarcoma (EWS) is a challenging pediatric cancer characterized by vast intra-tumor heterogeneity. We evaluated the RNA-binding protein IGF2BP3, whose high expression correlates with a poor prognosis and an elevated tendency of metastases, as a possible soluble mediator of inter-cellular communication in EWS. Our data demonstrate that (i) IGF2BP3 is detected in cell supernatants, and it is released inside extracellular vesicles (EVs); (ii) EVs from IGF2BP3-positive or IGF2BP3-negative EWS cells reciprocally affect cell migration but not the proliferation of EWS recipient cells; (iii) EVs derived from IGF2BP3-silenced cells have a distinct miRNA cargo profile and inhibit the PI3K/Akt pathway in recipient cells; (iv) the 11 common differentially expressed miRNAs associated with IGF2BP3-positive and IGF2BP3-negative EVs correctly group IGF2BP3-positive and IGF2BP3-negative clinical tissue specimens. Overall, our data suggest that IGF2BP3 can participate in the modulation of phenotypic heterogeneity.