bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bioevaluation of antibacterial potential of Sarpgandha (Rauwolfia serpentina)
Authors: Upadhayay Vishal , Deepika  , Singh Padma , Kaushik P. 
Published: February 2023

The in vitro antibacterial activity of Rauwolfia serpentina plant extract has been investigated against Escherichia coli, Staphylococcus aureus, Salmonella typhi and Klebsiella pneumoniae using the disc diffusion method. The alcoholic extract was found effective against Staphylococcus aureus only. The antibacterial activity is attributed to the presence of alkaloids, which was confirmed by gas liquid chromatography and positive alkaloid test. The minimum inhibitory concentration (MIC) was determined by paper disc diffusion method. The results were compared with reference antibiotic tetracycline (one unit solution).
Antimicrobial activity of Vitex negundo leaf extracts
Authors: Deepika  , Singh Padma , Upadhayay Vishal 
Published: February 2023

Methanol, diethyl ether and acetone extracts of leaf of itex negundo were tested for their antibacterial activity against two human pathogenic bacteria Staphylococcus aureus, Pseudomonas aeruginosa and one fungus Aspergillus niger using the disc diffusion method. It was found that all the extracts produced inhibitory effect but the methanol extract of leaves exhibited a superior level of antimicrobial activity. The minimum inhibitory concentration(M IC) and minimum fungicidal concentration(MFC)was determined by broth dilution method. The results were compared with the reference antibiotics.
Abiotic factors of Yashwant Nagar Taalab, Mhow (M.P.)
Authors: Saxena Gopal , Prakash M.M. 
Published: February 2023

In the present paper the status of water quality of Yashwant Nagar Taalab was determined. The different parameters which were analyzed during the study are temperature, conductivity, pH, total suspended solid, DO, BOD, silicates. chloride, nitrate, phosphate, sulphate. During course of study minor differance were observed in parameter studied.
Fish and fisheries of Virla Reservoir of West Nimar, District M.P., India
Authors: Pathak S. K. , Mudgal K. 
Published: February 2023

During course of study on virla reservoir West Nimar (Kargone) M.P., India, total 29 species of fish biodiversity were recorded these belong 6 orders, IO families and 16 genera were observed. On the basis of economic importance fishes weredivided into three major groups viz. catfish (Mystus seenghala, Mystus tengara, Wallago attu and Ompok bimaculattus), major carp (Cat/a cat/a, Labeo rohita and Cirrhinus mrigala) and miscellaneous (Channa sps., Mastacembelus sps. and Notopterus notoptereus). The water body was divided into three zones viz. upstream zone, reservoir zone and downstream zone for fish catch. Tha total annual fish catch computed in this water body was 2465.40 kg. and 2576.40 kg. during the 2001-02 and 2002-03 respectively. The minimum catch were observed in August while maximum in May. The percentage composition of major carp shows decline trend and catfishes shows increasing trend during two years study time. Catch per unit effort (CPUE) ranged between 0.015 to 0.191 kg/ hrs. The water level fluctuations and fish production show inverse relationship.
Snowtrout fishery in Garhwal Himalaya: Causes of depletion and strategy for propagation
Authors: Agarwal N.K. , Singh Harpal 
Published: February 2023

Snowtrout (Schizothorax sp.) is an important group of fishes in Indian uplands and is prone to decline due to several anthropogenic activities and natural disasters. However, the natural behaviour of the group is also one of the important constraints for its self-propagation in the nature. It requires attention for the conservation and propagation through in-situ as well as ex-situ measures. The in-situ refers to - aquaculture under controlled conditions for propagation of the group by developing artificial breeding programmes for high seed requirement, better management of incubation patterns and rational management of water bodies including development of sanctuaries, where the fishing would be banned. The artificial breeding and snowtrout seed production technique in flow through hatchery can be adopted at commercial level for mass scale snowtrout seed production. Sometimes unavailability of either sex of the mature brooder at the time of artificial fertilization in hatchery is a major constraint in the artificial breeding programmes. Cryopreservation of gametes has emerged as a promising and a very useful technique to facilitate artificial breeding in several fishes. The cryopreservation of milt of snowtrout finds its role right here. Initial attempts for developing cryopreservation protocol for snowtrout milt are very much promising. More concerted efforts for commercializing the reproductive techniques including cryopreservation of gametes will certainly be helpful for the strategic propagation of snowtrout in cold-water bodies.
Bacteriological characteristics of raw water of the river Tawi near Sitlee water treatment plant, Jammu
Authors: Khajuria Meenakshi , Dutta SPS 
Published: February 2023

Bacteriological analysis of raw water of the river Tawi, near Sitlee water treatment plant, has shown the seasonal presence of Kiebsiella. Ctrobacter, Escherichia and Pseudomonas. Total bacterial count (MPN) recorded summer (April, May). monsoon and post-monsoon (June- October) increase and winter (November, December, February) decrease. It varied between 92 and >180 during both the years of study MPN index above 10 /100 ml indicates that raw water is not suitable for drinking purposes and comes under the category of unsatisfactory. It needs proper treatment before supplied to the consumers.
Spiders fauna from G.V.I.S.H. Campus, Amravati (M.S.)
Authors: Deshmukh Ujjawala S. 
Published: February 2023

The spiders from G.V.l.S.H. Campus, Amravati (M.S.) were collected from first week of August to last week of November 2008, using insect nets, tapping sticks, umbrella, pit fall trap etc. During the study 470 specimens were collected from different area of campus.35 species belonging to 12 families were identified. Family Araneidae represented 7 species, Salticidae represented 6 species, Oxyopidae and Eracidae represented 4 species, Theriddidae and Thomisidae represented 3 species each, families Lycosidae and Pholcidae represented 2 species, families Clubionidae, Philodrpmidae, Tetragnathidae Uloboridae, represent single species. The population of spiders was abundant. Species richness and diversity was high during the month of September and October, the population of species Stegodyphus was observed largely during the month of November.
FACTORS ASSOCIATED WITH VACCINE ACCEPTANCE AND RECOMMENDATION AMONG DENTAL STUDENTS AND FACULTY PREVIOUSLY INFECTED WITH COVID-19; A STUDY FROM SAUDI ARABIA
Authors: Osama Abu-Hammad  , Shaden Abu-Hammad  , Safa Jambi  , Nebras Althagafi  , Rawah Eshky  , Aljohani Rahaf Saeed , Rahaf Ayeq  , Layan Ghazi  , Heba Alsubhi  , Abdalla Abu-Hammad  , Malak Abu-Hammad  , Dar-Odeh Najla 
Published: February 2023

This study aims to explore vaccine acceptance and recommendation behaviors among clinical dental students and their faculty who were previously infected with SARS-CoV-2. The study was conducted among previously infected dental healthcare personnel (DHCP) in an academic setting to evaluate their willingness to accept vaccines and recommend them to family and patients. Logistic regression was conducted to determine significant variables associated with vaccine attitudes. Among 316 personnel 62 indicated previous infection (19.6%). Personnel who were willing to take the vaccine, or recommend it to patients, or to family were: 67.7%, 87.1%, and 85.5% respectively. Vaccine acceptance was significantly associated with vaccine awareness and number of long-term COVID-19 complications (P=.003, .033 respectively). Vaccine recommendation to family, and patients was significantly associated with vaccine awareness only (P=.005, .006 respectively). It is concluded that some previously infected academic dental personnel are unwilling to accept COVID-19 vaccines or recommend them to others. This was mainly due to lack of vaccine awareness. Efforts directed at increasing COVID-19 vaccine awareness are warranted by dental schools in collaboration with Ministry of Health authorities. It is also necessary to closely monitor, and provide support to personnel affected by long COVID
Activity of Ceﬁderocol and Other New Antibiotics Against Extensively Drug-Resistant <i>Klebsiella pneumoniae</i> Strains
Authors: Karpova E. V. , Tapalski D. V. 
Published: February 2023

Background. The spread of extensive drug-resistance among gram-negative bacteria calls for the search for antimicrobics with new mechanisms of actions.The aim was to assess susceptibility of extensively drug-resistant K. pneumoniae strains to ceﬁderocol and other new inhibitor-protected β-lactams, and to determine genetic mechanisms of antibiotic resistance.Methods. This study included 30 extensively drug-resistant K. pneumoniae strains collected in 2016–2021 from 4 regions of Belarus. Carbapenemase genes were detected by real-time PCR. Minimum inhibitory concentrations (MICs) for ceﬁderocol and other new antibiotics were assessed by microdilution method using the Sensititre system. Whole genome sequencing was performed for 2 resistant and 3 ceﬁderocol-susceptible strains. Genome assemblies and annotation were performed using UGENE v. 37.0 software. Nucleotide sequences were translated using CLC Sequence Viewer v. 8.0 (QIAGEN) package. The PROVEAN software was used to assess amino asides substitutions and their inﬂuence on the functional activity of proteins.Results. KPC carbapenemase-producers were 4 strains, OXA-48 — 17, KPC+OXA-48 — 1, NDM — 7, OXA-48 + NDM — 1. All KPC-producers were susceptible to imipenem/relebactam and meropenem/vaborbactam. Resistance to ceftazidime-avibactam was noted in all NDM producers and OXA-48+NDM co-producer. The study has identiﬁed 9 ceﬁderocol-resistant strains. These were NDM and OXA-48-producers isolated from hospitalized patients with COVID-19 infection from 3 regions of Belarus. Resistant strains had functionally signiﬁcant nonsynonymous substitutions in the genes of TonB-dependent receptors for catecholate siderophores FepA (F472V, P64S) and Fiu (T92S).Conclusion. The study has shown high eﬃcacy of new inhibitor-protected carbapenems and cephalosporins against certain types of carbapenemase-producers. Strains with mutational resistance to ceﬁderocol, an antibiotic not previously used in Belarus, have been identiﬁed.
Antibacterial and Antimycotic Properties of Modiﬁed Carbon Sorbents
Authors: Dolgikh V. T. , P’yanova L. G. , Lavrenov A. V. , Naumkina E. V. , Sedanova A. V. , Delyagina M. S. , Ogurtsova D. N. 
Published: February 2023

The aim of the work was to study the biological activity of modiﬁers and carbon sorbent samples modiﬁed by them in relation to some types of microorganisms.Material and methods. The carbon sorbent under study and the modiﬁed samples were obtained at the Center of New Chemical Technologies BIC. Glycolic acid, lactic acid, glycine, and glutamic acid were used as modiﬁers. Strains of Staphylococcus aureus ATCC 25923, Pseudomonas aeruginosa ATCC 27853, Klebsiella pneumoniae 418, Esherichia coli ATCC 25922, Candida albicans (clinical strain) were used as test cultures. The test sample was placed in the wells of a sterile plate, then a working suspension of the test culture was added in the amount of 2.0 ml until completely wet 1:1. The survival of microorganisms was determined by quantitative inoculation from each well of the «sample — microorganism» mixture on Petri dishes with simple nutrient agar using the sector crop method (Gold). The culture species were conﬁrmed by studying their cultural, morphological, and biochemical properties.Results. The conducted studies have demonstrated high antibacterial and antimycotic activity of carbon sorbent samples modiﬁed with hydroxyl acids in relation to the most common opportunistic pathogens of pyoinﬂammatory diseases of bacterial and fungal nature in comparison with the initial sorbent sample. The carbon sorbent modiﬁed with lactic acid oligomer showed the highest antibacterial and antimycotic activity.Conclusion. High antibacterial and antimycotic activity of carbon sorbent samples modified with hydroxy acids and amino acids in relation to the most common opportunistic pathogens of pyoinflammatory diseases of bacterial and fungal nature was established in comparison with the initial sample of the sorbent. The carbon sorbent sample modified with amino acids has a pronounced antibacterial effect against all studied bacterial test strains, but exhibits weak antimycotic properties. The use of modified carbon sorbents is a promising direction for the application therapy of pyoinflammatory infections.
Some Peculiarities of Modern Comorbid Tuberculosis Therapy
Authors: Kolomiets V. M. , Kovalenko A. L. , Petrov A. Yu. , Pavlenko E. P. , Talikova E. V. 
Published: February 2023

The aim of the work was to study the eﬀectiveness of remaxol inclusion in treatment regimens designed for patients with comorbid tuberculosis and hepatotoxic response to etiotropic therapy.Materials and Methods. Case histories of 25 patients (21 men and 4 women) with a conﬁrmed diagnosis of tuberculosis infection and hepatotoxic reactions to etiotropic treatment were analyzed. Of these, 9 patients had a comorbid (TB/HIV) pathology and 16 patients had TB/HIV with concomitant diseases. To stop the signs of hepatotoxicity, all patients were prescribed with remaxol: 400 ml intravenously on alternate days (course No. 5), then 1 time per week (course No. 4). In addition to the standard clinical and laboratory examination, all patients underwent follow-up (before and after the course of remaxol) examination of the levels of aspartate aminotransferase and total bilirubin in the blood, as well as the levels of interleukin production (1β, 4, 6 and 10) and tumor necrosis factors (TNF-α and TNF-γ). Standard regimens were used when conducting anti-tuberculosis chemotherapy.Results. It was noted that the presence of a comorbidity aggravates the course of tuberculosis and reduces the eﬀectiveness of etiotropic therapy due to the development of hepatotoxicity. The inclusion of remaxol contributed to a decrease in the severity of hepatotoxic reactions and made it possible to avoid the correction of the main treatment course. The revealed positive dynamic in cytokine proﬁle indicators can be regarded as a mediated immunological eﬀect of the drug and requires further research.
Ototoxicity of Aminoglycosides the Modern Concepts
Authors: Shubnikova E. V. , Velts N. Yu. 
Published: February 2023

Aminoglycosides are broad-spectrum antibacterial agents used in the treatment of urinary tract infections, tuberculosis, visceral leishmaniasis, sepsis in newborns, as well as cystic fibrosis. However, the use of aminoglycosides is limited due to their ototoxicity — the risk of developing serious adverse reactions, in particular, persistent irreversible hearing loss and vestibular disorders associated with the death of hair cells in the inner ear. The review analyzes scientific data on the possible mechanisms of aminoglycosides’ damaging effect on the hair cells of the inner ear. Genetically determined causes contributing to the manifestation of ototoxic properties of drugs of this group are described. The necessity of genetic screening for the carriage of mutations m.1555A>G and m.1494C>T in the MT-RNR1 gene of mitochondrial DNA is substantiated in order to minimize the risk of hearing disorders in patients with hereditary predisposition. Understanding the mechanisms of ototoxicity of aminoglycosides will make it possible to find ways to prevent and correct hearing loss after their use.
TINJAUAN HUKUM ISLAM TERHADAP PRAKTIK DIFERENSIASI HARGA KELAPA ANTARA ORANG YANG BERUTANG DAN ORANG YANG TIDAK BERUTANG
Authors: Dawati Dini Faslin 
Published: February 2023

Jual beli merupakan suatu kegiatan yang sangat sering dilakukan. Jual beli bisa di katakan berupa tukar-menukar suatu barang dengan barang yang lain dengan cara tertentu. Terdapat berberapa syarat-syarat dan rukun yang harus di penuhi agar jual beli menjadi sah. Dengan terpenuhinya segala syarat-syarat dan rukun jual beli, maka konsekuensinya adalah penjual memindahkan miliknya kepada pembeli begitu saja. Pembeli memindahkan miliknya kepada penjual sesuai dengan harga yang telah di tentukan. Tinjauan hukum Islam terkait dengan praktik diferensiasi harga kelapa antara orang yang berutang dan orang yang tidak berutang terdapat perbedaan harga antara orang yang berutang dan orang yang tidak berutang tersebut dibolehkan (mubah) karena di pengaruhi oleh berberapa faktor yang menyebabkan hal tesebut terjadi dan dilakukan. Kegiatan tersebut sudah sesuai dengan konsep harga dalam Islam dan juga sesuai dengan syarat-syarat penentuan harga yaitu sesuai dengan prinsip-prinsip muamalah dan konsep harga yang adil dalam Islam. Dalam proses jual beli tersebut juga sudah memenuhi rukun dan syarat dalam Islam, sehingga jual beli ini hukumnya sah.
The SPHINX M-dwarf Spectral Grid. I. Benchmarking New Model Atmospheres to Derive Fundamental M-dwarf Properties
Authors: Iyer Aishwarya R. , Line Michael R. , Muirhead Philip S. , Fortney Jonathan J. , Gharib-Nezhad Ehsan 
Published: February 2023

Abstract
About 70%–80% of stars in our solar and Galactic neighborhood are M dwarfs. They span a range of low masses and temperatures relative to solar-type stars, facilitating molecule formation throughout their atmospheres. Standard stellar atmosphere models primarily designed for FGK stars face challenges when characterizing broadband molecular features in spectra of cool stars. Here, we introduce SPHINX—a new 1D self-consistent radiative–convective thermochemical equilibrium chemistry model grid of atmospheres and spectra for M dwarfs in low resolution (R ∼ 250). We incorporate the latest precomputed absorption cross sections with pressure broadening for key molecules dominant in late-K, early/main-sequence-M stars. We then validate our grid models by determining fundamental properties (T
eff, log g, [M/H], radius, and C/O) for 10 benchmark M+G binary stars with known host metallicities and 10 M dwarfs with interferometrically measured angular diameters. Incorporating the Gaussian process inference tool Starfish, we account for correlated and systematic noise in low-resolution (spectral stitching of SpeX, SNIFS, and STIS) observations and derive robust estimates of fundamental M-dwarf atmospheric parameters. Additionally, we assess the influence of photospheric heterogeneity on inferred [M/H] and find that it could explain some deviations from observations. We also probe whether the adopted convective mixing length parameter influences inferred radii, effective temperature, and [M/H] and again find that may explain discrepancies between interferometric observations and model-derived parameters for cooler M dwarfs. Mainly, we show the unique strength in leveraging broadband molecular absorption features occurring in low-resolution M dwarf spectra and demonstrate the ability to improve constraints on fundamental properties of exoplanet hosts and brown-dwarf companions.
Usages du téléphone mobile et spatialité : Réflexions à partir du cas des femmes du Moungo central (Cameroun)
Authors: Pasini Jérémy 
Published: February 2023

Au Cameroun, les déplacements des femmes s’effectuent généralement dans une zone réduite autour du domicile et sous étroite surveillance des hommes. Dans ce contexte, nous nous demandons en quoi l’appropriation, l’adaptation et l’utilisation par les femmes du téléphone portable peut les aider à obtenir davantage de maîtrise spatiale. Pour traiter cette problématique, nous nous appuyons sur la théorie des "arts de faire" (De Certeau, 1990), qui reconnaît aux individus une part d’autonomie dans l’usage qu’ils font d’une technologie. Nous faisons l’hypothèse que les femmes sont capables de détourner l’usage attendu du téléphone portable pour opérer des choix spatiaux (téléphoner plutôt que se déplacer, mettre à distance une personne en refusant de lui dévoiler sa localisation, etc.). Selon cette hypothèse, le téléphone portable est donc un outil de la "motilité" (Kaufman, Jemelin, 2004), voire de la "spatialité" (Lussault, 2007). À partir de données collectées dans le Moungo (Cameroun) entre 2014 et 2016, nous montrons que le recours au téléphone portable confère aux femmes un contrôle accru sur leurs usages de l’espace (coordination plus aisée des sorties collectives, report plus facile du retour au domicile, etc.). Cependant, nous soulignons aussi que toutes les femmes ne profitent pas de manière équivalente du téléphone portable. Nous proposons de porter attention à trois facteurs qui expliquent l’inégale faculté des femmes à mettre le téléphone portable au service de leur "spatialité" : le capital financier, le niveau d’éducation et l’âge.
Assessment of knowledge, attitude, and practice towards adverse drug reaction reporting among healthcare students of Namakkal District, Tamil Nadu
Authors: Sam Subin , Thomas CV Juvin , M Sudha , R Sambathkumar 
Published: February 2023

Background: Adverse drug reactions (ADRs) are recognised causes of increased mortality, morbidity, and high healthcare costs. The contribution of healthcare students to ADR databases is essential and has enabled continued drug detection to such an extent that it has led to identifying unsuspected and rare ADR signals.
Objectives: The study aims to evaluate healthcare students’ knowledge, attitude, and practice (KAP) toward ADR reporting.
Methods: This descriptive, cross-sectional study was conducted among 265 healthcare students of Namakkal district, Tamil Nadu, from various departments. A three-section questionnaire was developed in English and distributed online from July to October 2020. Each participant received a score for each KAP section.
Results: Of the 265 healthcare students included in the study, 56.98% were female. The majority were pharmacy students 132 (49.81%), followed by medical 74 (27.92%) and nursing 59 (22.26%) students. There was a significant difference in ADR reporting among healthcare students. KAP of ADR reporting was higher among pharmacy students (88.68%) compared to the medical (19.25%) and nursing students (29.63%), with a p-value of 0.05.
Conclusion: This study showed that pharmacy students had more awareness of ADR reporting than other healthcare students due to pharmacovigilance courses in their curriculum and adequate training during clerkships and internships. Hence, it is necessary to include pharmacovigilance and ADR reporting in other healthcare curriculum to reduce ADR underreporting in the future. Periodic educational interventions can improve these parameters of pharmacovigilance.