bluuebunny/crossref_metadata_2025_split huggingface dataset:
Informed consent in cancer clinical drug trials in China: a narrative literature review of the past 20 years
Authors: Liu Xing , Lu Xiaoran , Zhou Wei , Hahne Jessica , Khoshnood Kaveh , Shi Xiaoting , Zhong Yuqiong , Wang Xiaomin 
Published: July 2023

AbstractBackgroundAlthough the number of cancer clinical drug trials is increasing rapidly in China, issues concerning informed consent in this research context are understudied. By performing a narrative literature review, we aim to describe the current situation and identify the most salient challenges affecting informed consent in cancer clinical drug trials among adult patients in China since 2000.MethodsWe searched Web of Science (WOS), PubMed, Scopus, EMBASE, the Cochrane Library databases, China National Knowledge Infrastructure (CNKI), China Biomedical Literature Database on Disc (CBMdisc), Chinese Scientific Journals Fulltext Database (CQVIP), and WANFANG Data to identify relevant publications since 2000. Data were extracted by three reviewers on six items pertaining to study type, theme, and challenges.ResultsWe identified 37 unique manuscripts, from which 19 full texts were obtained and six were included in the review. All six studies were published in Chinese journals, and the publication years of the majority (five out of six) of the studies were 2015 or later. The authors of the six studies were all from clinical departments or ethical review committees at five hospitals in China. All of the included publications were descriptive studies. Publications reported challenges related to the following aspects of informed consent: information disclosure, patient understanding, voluntariness, authorization, and procedural steps.ConclusionBased on our analysis of publications over the past two decades, there are currently frequent challenges related to various aspects of informed consent in cancer clinical drug trials in China. Furthermore, only a limited number of high-quality research studies on informed consent in cancer clinical drug trials in China are available to date. Efforts toward improvement of informed consent practice, in the form of guidelines or further regulations in China, should draw on both experience from other countries and high-quality local evidence.
Evaluation of rRNA depletion methods for capturing the RNA virome from environmental surfaces
Authors: Shiwa Yuh , Baba Tomoya , Sierra Maria A. , Kim JangKeun , Mason Christopher E. , Suzuki Haruo 
Published: July 2023

Abstract
Objective
Metatranscriptomic analysis of RNA viromes on built-environment surfaces is hampered by low RNA yields and high abundance of rRNA. Therefore, we evaluated the quality of libraries, efficiency of rRNA depletion, and viral detection sensitivity using a mock community and a melamine-coated table surface RNA with levels below those required (< 5 ng) with a library preparation kit (NEBNext Ultra II Directional RNA Library Prep Kit).

Results
Good-quality RNA libraries were obtained from 0.1 ng of mock community and table surface RNA by changing the adapter concentration and number of PCR cycles. Differences in the target species of the rRNA depletion method affected the community composition and sensitivity of virus detection. The percentage of viral occupancy in two replicates was 0.259 and 0.290% in both human and bacterial rRNA-depleted samples, a 3.4 and 3.8-fold increase compared with that for only bacterial rRNA-depleted samples. Comparison of SARS-CoV-2 spiked-in human rRNA and bacterial rRNA-depleted samples suggested that more SARS-CoV-2 reads were detected in bacterial rRNA-depleted samples. We demonstrated that metatranscriptome analysis of RNA viromes is possible from RNA isolated from an indoor surface (representing a built-environment surface) using a standard library preparation kit.
Extracorporeal hemoadsorption therapy as a potential therapeutic option for rapid removal of Apixaban in high risk-surgical patients: a case report
Authors: Dalmastri Vittorio , Angelini Andrea , Minerva Vera , Ballarini Melissa , Grammatico Francesco , Todeschini Paola , Pizzini Attilia Maria , Silingardi Mauro , La Manna Gaetano 
Published: July 2023

Abstract
Background
Apixaban is a non-vitamin K antagonist oral anticoagulant (NOACs) recently emerged as an effective alternative to conventional vitamin K antagonists (VKAs) in the treatment of several thromboembolic disorders. However, in case of overdose or in patients requiring emergency surgery there is a high bleeding rate and severe adverse side effects due to the absence of an antidote. There is promising data from in vitro and clinical studies, that certain antithrombotic agents (that is Rivaroxaban and Ticagrelor) have been successfully removed by the extracorporeal hemoadsorption therapy CytoSorb. Here, we present the case of a patient successfully treated with CytoSorb as a kind of antidote to enable emergency surgery for bilateral nephrostomy.

Case presentation
A 82-year-old Caucasian man was admitted to the Emergency Room with acute kidney injury (AKI) in the context of severe bilateral hydroureteronephrosis. The patient’s medical history included chronic obstructive pulmonary disease, arterial hypertension, atrial fibrillation (anticoagulated with Apixaban) and a locally advanced prostate adenocarcinoma treated with trans-ureteral resection of the bladder and radiotherapy in the previous months. The indication for a bilateral nephrostomy could not be considered immediately given the major bleeding risk due to Apixaban, which was discontinued and replaced with calciparin. After 36 hours of continuous renal replacement therapy (CRRT), the Apixaban blood level was still elevated and it was decided to install CytoSorb into the running CRRT to accelerate the drug clearance. After 2 hours 30 minutes, there was good reduction of Apixaban from 139 to 72 ng/ml (reduction rate of 48.2%) registered, and this allowed for an easy placement of bilateral nephrostomies without complications. Four days after surgery renal function parameters further normalized, the patient did not require additional dialysis treatments and Apixaban therapy was prescribed again once the patient returned home.

Conclusions
In this case we report the findings of a patient with post-renal AKI requiring emergency nephrostomy placement while on chronic anticoagulation with Apixaban therapy. Combined treatment with CRRT and CytoSorb was associated with the rapid and effective removal of Apixaban allowing for prompt and urgent surgery while simultaneously ensuring the low risk of bleeding as well as an uneventful post-operative course.
Antioxidant and chemoprotective potential of Streptomyces levis strain isolated from human gut
Authors: Verma Jaya , Attri Shivani , Arora Saroj , Manhas Rajesh Kumari 
Published: July 2023

AbstractIn the current study,Streptomyceslevisstrain HFM-2 has been isolated from healthy human gut.Streptomycessp. HFM-2 was identified based on the polyphasic approach that included cultural, morphological, chemotaxonomical, phylogenetic, physiological, and biochemical characteristics. 16S rRNA gene sequence of strain HFM-2 exhibited 100% similarity withStreptomyceslevisstrain 15423 (T). The EtOAc extract ofStreptomyceslevisstrain HFM-2 showed potential antioxidant activity, along with 69.53 ± 0.19%, 64.76 ± 0.13%, and 84.82 ± 0.21% of scavenging activity for ABTS, DPPH, and superoxide radicals, respectively at 600 µg/mL. The IC50values i.e. 50% scavenging activity for DPPH, ABTS, and superoxide radicals were achieved at 497.19, 388.13, and 268.79 (µg/mL), respectively. The extract's reducing power and total antioxidant capacity were determined to be 856.83 ± 0.76 and 860.06 ± 0.01 µg AAE/mg of dry extract, respectively. In addition, the EtOAc extract showed protection against DNA damage from oxidative stress caused by Fenton’s reagent, and cytotoxic activity against HeLa cervical cancer, Skin (431) cancer, Ehrlich-Lettre Ascites-E (EAC) carcinoma, and L929 normal cell lines. The IC50values against HeLa, 431 skin, and EAC carcinoma cell lines were found to be 50.69, 84.07, and 164.91 µg/mL, respectively. The EtOAc extract showed no toxicity towards L929 normal cells. In addition, flow cytometric analysis exhibited reduced mitochondrial membrane potential (MMP), and enhanced levels of reactive oxygen species (ROS). The EtOAc extract was chemically analyzed using GCMS to determine the components executing its bioactivities.
Methods of postoperative void trial management after urogynecologic surgery: a systematic review and meta-analysis
Authors: Dong Xue , Huang Wu , Niu Jinyang , Lei Tingting , Tan Xin , Guo Tao 
Published: July 2023

Abstract
Background
Voiding trials are used to identify women at risk for postoperative urinary retention while performing optimal voiding trial management with minimal burden to the patient and medical service team. We performed a systematic review and meta-analysis of postoperative void trials following urogynecologic surgery to investigate (1) the optimal postoperative void trial methodology and (2) the optimal criteria for assessing void trial.

Method
We searched PubMed, EMBASE, Cochrane Central Register of Controlled Trials, and relevant reference lists of eligible articles from inception to April 2022. We identified any randomized controlled trials (RCTs) in English that studied void trials in patients undergoing urogynecologic surgery. Study selection (title/abstract and full text), data extraction, and risk of bias assessment were conducted by two independent reviewers. Extracted study outcomes included the following: the correct passing rate, time to discharge, discharge rate without a catheter after the initial void trial, postoperative urinary tract infection, and patient satisfaction.

Results
Void trial methodology included backfill-assisted and autofill studies (2 RCTs, n = 95). Backfill assistance was more likely to be successful than autofill (RR 2.12, 95% CI 1.29, 3.47, P = 0.00); however, no significant difference was found in the time to discharge (WMDs =  − 29.11 min, 95% CI − 57.45, 1.23, P = 0.06). The criteria for passing void trial included subjective assessment of the urinary force of stream and objective assessment of the standard voiding trial (3 RCTs, n = 377). No significant differences were found in the correct passing rate (RR 0.97, 95% CI 0.93, 1.01, P = 0.14) or void trial failure rate (RR 0.78, 95% CI 0.52, 1.18, P = 0.24). Moreover, no significant differences were found in the complication rates or patient satisfaction between the two criteria.

Conclusion
Bladder backfilling was associated with a lower rate of catheter discharge after urogynecologic surgery. The subjective assessment of FOS is a reliable and safe method for assessing postoperative voiding because it is less invasive.

Systematic review registration
PROSPERO CRD42022313397
On shrinking projection method for cutter type mappings with nonsummable errors
Authors: Ibaraki Takanori , Saejung Satit 
Published: July 2023

AbstractWe prove two key inequalities for metric and generalized projections in a certain Banach space. We then obtain some asymptotic behavior of a sequence generated by the shrinking projection method introduced by Takahashi et al. (J. Math. Anal. Appl. 341:276–286, 2008) where the computation allows some nonsummable errors. We follow the idea proposed by Kimura (Banach and Function Spaces IV (ISBFS 2012), pp. 303–311, 2014). The mappings studied in this paper are more general than the ones in (Ibaraki and Kimura in Linear Nonlinear Anal. 2:301–310, 2016; Ibaraki and Kajiba in Josai Math. Monogr. 11:105–120, 2018). In particular, the results in (Ibaraki and Kimura in Linear Nonlinear Anal. 2:301–310, 2016; Ibaraki and Kajiba in Josai Math. Monogr. 11:105–120, 2018) are both extended and supplemented. Finally, we discuss our results for finding a zero of maximal monotone operator and a minimizer of convex functions on a Banach space.
Decay rate of the solutions to the Cauchy problem of the Bresse system in thermoelasticity of type III with distributed delay
Authors: Choucha Abdelbaki , Boulaaras Salah , Jan Rashid , Guefaifia Rafik 
Published: July 2023

AbstractThe decay rate of solutions to a Bresse system in thermoelasticity of type III with respect to the distributed delay term is the subject of this study. We demonstrate our major finding utilising the energy approach in the Fourier space.
Social inequalities in self-perceived health in Chile, does the urban environment matter?: a cross-sectional study
Authors: López-Contreras Natalia , Puig-Barrachina Vanessa , Vives Alejandra , Olave-Müller Paola , Gotsens Mercè 
Published: July 2023

Abstract
Background
The health of a population is determined by urban factors such as the physical, social and safety environment, which can be modified by urban regeneration policies. The aim of this study was to analyze the associations of elements of the social, physical and safety environment of the neighborhood in the urban context with self-perceived health (SPH), according to axes of inequality, such as gender and educational level in Chile in 2016.

Methods
Cross-sectional study using a nationally representative population-based survey of Chile. We used data from the 2016 National Survey of Quality of Life and Health. Poor SPH in the urban population older than 25 years was analyzed in relation to social, physical and safety environment variables. Poisson multilevel regression models were estimated to obtain prevalence ratios (PR) and their respective 95% confidence intervals (95%CI). All analyses were stratified by sex and educational level.

Results
SPH was worse in women than in men, especially in those with a lower education level. Poor SPH was associated with lack of support networks (PR = 1.4; 95%CI = 1.1–1.7), non-participation in social organizations (PR = 1.3; 95%CI = 1.1–1.6) and perceived problems with the quality of public space (PR = 1.3; 95%CI = 1.2–1.5) in women with a medium-high educational level and with a feeling of not belonging to the neighborhood (PR = 1.5; 95%CI = 1.2–1.8) and the perception of pollution problems (PR = 1.2; 95%CI = 1.0-1.4) in women with a low educational level. A feeling of unsafety was associated with both educational levels (PR = 1.3; 95%CI = 1.0-1.5). Poor SPH was associated with the feeling of not belonging (PR = 1.7; 95%CI = 1.2–2.5), and unsafety (PR = 2.1; 95%CI = 1.8–2.4) in men with a medium-high educational level, while there were fewer associations in men with a lower education level.

Conclusions
Urban interventions are recommended to improve the health of the resident population and should take into account axes of inequality.
Do founders attribute their success to skill or luck?
Authors: Lough Benjamin J. , McFadden Alyssa 
Published: July 2023

AbstractThis study analyzes transcripts derived from 183 podcast interviews that ask successful entrepreneurs whether luck or skill and hard work account for their success. It quantitatively disaggregates founders’ answers to this standard question based on differences in their gender, race, and geography of their birth. Qualitative analysis further considers the degree to which founders’ perspectives might be associated with an internalized locus of control and their social positioning, alongside their identities and belief systems. Results indicate differences across gender, but no strong evidence of difference was evident by race and geography. Thematic analysis of transcripts revealed several additional determinants that founders attributed to their success. By investigating the lived experiences of successful founders disaggregated by gender, race, and geography, this study sheds light on how diverse founders attribute their success to various internal and external forces.
Engaging diverse patients in a diverse world: the development and preliminary evaluation of educational modules to support diversity in patient engagement research
Authors: Michalak Erin E. , Cheung Iva W. , Willis Elsy , Hole Rachelle , Pomeroy Beverley , Morton Emma , Kanani Sahil S. , Barnes Steven J. 
Published: July 2023

Abstract
Background
Current practices for engaging patients in patient-oriented research (POR) result in a narrow pool of patient perspectives being reflected in POR. This project aims to address gaps in methodological knowledge to foster diversity in POR, through the co-design and evaluation of a series of educational modules for health researchers in British Columbia, Canada.

Methods
Modules were co-created by a team of academic researchers and patient partners from hardly-reached communities. The modules are presented using the Tapestry Tool, an interactive, online educational platform. Our evaluation framework focused on engagement, content quality, and predicted behavior change. The User Engagement Scale short form (UES-SF) measured participants’ level of engagement with the modules. Survey evaluation items assessed the content within the modules and participants' perceptions of how the modules will impact their behavior. Evaluation items modeled on the theory of planned behavior, administered before and after viewing the modules, assessed the impact of the modules on participants’ perceptions of diversity in POR.

Results
Seventy-four health researchers evaluated the modules. Researchers’ engagement and ratings of module content were high. Subjective behavioral control over fostering diversity in POR increased significantly after viewing the modules.

Conclusions
Our results suggest the modules may be an engaging way to provide health researchers with tools and knowledge to increase diversity in health research. Future studies are needed to investigate best practices for engaging with communities not represented in this pilot project, such as children and youth, Indigenous Peoples, and Black communities. While educational interventions represent one route to increasing diversity in POR, individual efforts must occur in tandem with high-level changes that address systemic barriers to engagement.
Shifts in the rhizosphere microbiome and exudation profile of avocado (Persea americana Mill.) during infection by Phytophthora cinnamomi and in presence of a biocontrol bacterial strain
Authors: Reverchon Frédérique , García-Meléndez Mariel , Guevara-Avendaño Edgar , Mora-Chávez Oscar , Solís-García Itzel A. , Dáttilo Wesley , Guererro-Analco José A. , Méndez-Bravo Alfonso , Monribot-Villanueva Juan L. , Patiño-Conde Violeta , Pineda-García Fernando , Rebollar Eria A. 
Published: July 2023

Abstract
Background
Rhizosphere microbiomes are fundamental for plant health, development, and productivity, but can be altered by the incidence of soil-borne pathogens. The dysbiosis (disturbance of the microbiome structure of healthy plants) caused by these pathogens, combined with the recruitment of beneficial microorganisms by the diseased plant, may cause shifts in the rhizosphere microbiome during the infection process. These shifts are likely to be associated with changes in the rhizosphere metabolic profile, as the biochemical dialog, or crosstalk, between host plants and their microbiome is mostly mediated by root exudates. Our objective was to elucidate the shifts in the avocado rhizosphere microbiome and associated changes in the rhizosphere metabolome induced by the infection of the oomycete Phytophthora cinnamomi. We also evaluated the effect of inoculating a bacterial biological control agent (BCA) of P. cinnamomi on the avocado rhizosphere microbiome, in the presence and absence of the pathogen, and on morphological and physiological plant variables, to confirm the potential of the BCA to alleviate the stress induced by the disease.

Dataset presentation
Here, we present a novel dataset collected from a time-course experiment with four treatments: (1) control trees; (2) trees infected with P. cinnamomi; (3) trees inoculated with the BCA; (4) trees infected with P. cinnamomi and inoculated with the BCA. During the infection process, we measured plant morphological and physiological variables and collected rhizosphere soil samples for bacterial and fungal amplicon sequencing, bacterial RNA-seq and metabolomic analyses.

Conclusions
Collectively, our data elucidate the shifts in the avocado rhizosphere microbiome after infection by P. cinnamomi and when inoculated with a BCA, and help understand how a pathogen or a beneficial bacterium can alter plant-microbiome crosstalk. Understanding the effect of P. cinnamomi or a BCA on the avocado tree physiology and on the avocado rhizosphere microbiome and metabolome will direct our search for disease biomarkers or potential pathogen antagonists, help identify metabolites related to the recruitment of microorganisms, and assist us in developing integrated disease management strategies.
A robust and consistent stack generalized ensemble-learning framework for image segmentation
Authors: Faska Zahra , Khrissi Lahbib , Haddouch Khalid , El Akkad Nabil 
Published: July 2023

AbstractIn the present study, we aim to propose an effective and robust ensemble-learning approach with stacked generalization for image segmentation. Initially, the input images are processed for feature extraction and edge detection using the Gabor filter and the Canny algorithms, respectively; our main goal is to determine the most feature descriptions. Subsequently, we applied the stacking generalization technique, which is generally built with two main learning levels. The first level is composed of two algorithms that give good results in the literature, namely: LightGBM (Light Gradient Boosting Machine) and SVM (support vector machine). The second level is the meta-model in which we use a predictor model that takes the base-level predictions to improve the accuracy of the final prediction. In the stacked generalization process, we use the Extreme Gradient Boosting (XGBoost); it takes as input the sub-models’ outputs to better classify each pixel of the image to give the final prediction. Today, several research works exist in the literature using different machine learning algorithms; in fact, instead of trying to find a single efficient and optimal learner, ensemble-based techniques take the advantage of each basic model; they integrate their outputs to obtain a more consistent and reliable learner. The result obtained from the models of individuals and our proposed approach is compared using a set of evaluation measures for image quality such as IoU, DSC, CC, SSIM, SAM, and UQI. The evaluation and a comparison of the results obtained showed more consistent predictions for the proposed model. Thus, we have made a comparison with some recent deep learning-based unsupervised segmentation methods. The evaluation and a comparison of the results obtained showed more coherent predictions for our stacked generalization in terms of precision, robustness, and consistency.
Identifying components existing in Agile software development for achieving “light but sufficient” documentation
Authors: Habib Basit , Romli Rohaida , Zulkifli Malina 
Published: July 2023

AbstractThe Agile nature allows changes within the development procedure which can sometimes be non-predictable and affect the cost and time of the software. Face-to-face communication appears to be a faster process in Agile Software Development (ASD) in practice, but issues such as understandability and communicativeness cause ambiguity between the customer and the developer. Among the existing works, achieving light but sufficient documentation in ASD remains a challenge. Most previous studies have simply highlighted the issues associated with less documentation, its limitations, and challenges, but no proper solution has yet been proposed. As an initial step in our theoretical study, we conducted a systematic literature review (SLR) to identify the related components and subcomponents that are applicable in supporting Agile documentation. As such, the fundamental concepts related to software documentation have been studied in order to align with documentation in ASD. The identification of these components can be useful in achieving the concept of “light but sufficient” documentation in Agile, which will aid in achieving customer satisfaction.