bluuebunny/crossref_metadata_2025_split huggingface dataset:
EFFECT OF THİAMİNE ON MORPHİNE ANALGESİA AND TOLERANCE İN RATS
Authors: ÇETİNDAĞ ÇİLTAŞ Arzuhan , ÖZTÜRK Ayşegül 
Published: March 2023

Absract: The latest research have demonstrated that inflammation, oxidative stress and apoptosis plays a majör role in morphine analgesia and tolerance development. This search goals to examine the possible role of thiamine use on oxidative stress, inflammation and apoptosis in the development of morphine analgesia and morphine tolerance in rats.
Methods: Thirty-six male Wistar rats were used in this study. The rats were severed into six groups: saline, 100 mg/kg thiamine, 5 mg/kg morphine, thiamine + morphine, morphine tolerance and thiamine + morphine tolerance. The resulting analgesic effect was measured by hot plate and tail movement analgesia tests. TAS and TOS, inflammation parameters, and apoptosis protein levels of the dorsal root ganglion tissues sample were measured using an ELISA kit.
Results: When thiamine was given alone, it did not show anti-nociceptive effect (p>0.05). In addition, thiamine enhanced the analgesic effect of morphine (p < 0.05) and also significantly reduced tolerance to morphine (p < 0.05). However, it reduced TOS when administered with a single dose of morphine and tolerance induction (p < 0.05). In addition, thiamine reduced apoptosis protein levels after tolerance development (p < 0.05).
Conclusion: Consequently, these results may attain by reducing TOS, inflammation, and apoptosis.
Social Phobia Prevalence among Academicians in Cumhuriyet University
Authors: ÖZDEMİR Levent , EKİCİ KOŞAROĞLU Nagehan , ALYILMAZ Asena İlbilge , BAYAZİT Tuğçe , GÜNDOĞDU Gamze , KILIÇ Esma , SÜMER Haldun 
Published: March 2023

Introduction and Aim: Social phobia; It is a public health problem that can lead to failure in
working life, major depression and even suicide.The aim of this study was to investigate the
prevalence of social phobia and related factors in academicians from Cumhuriyet University.
Method: This cross-sectional study was performed in 2017. The universe of the study
consists of 1605 academicians working in the health, science and social science fields of
Cumhuriyet University. The sample size was determined as 216. A two-part questionnaire
was applied to the participants. The first part consists of questions that investigating the
sociodemographic characteristics and the variables that we think are related to social phobia.
The second part consists of Liebowitz Social Anxiety Scale (LSAS)
Results: The frequency of social phobia was found to be 9.0%. While the prevalence of mild
and significant social phobia was 3.6%, the prevalence of social phobia was 1.8%. More than
half of the academicians show avoidance behavior in situations requiring performance.
Conclusion: As a result, it has been found that social phobia has a significant frequency of
9.0%. This situation, which may adversely affect the professional performance and mental
health of academicians, is important for public health.
Phenome-wide Mendelian randomization study of plasma triglyceride levels and 2600 disease traits
Authors: Park Joshua K , Bafna Shantanu , Forrest Iain S , Duffy Áine , Marquez-Luna Carla , Petrazzini Ben O , Vy Ha My , Jordan Daniel M , Verbanck Marie , Narula Jagat , Rosenson Robert S , Rocheleau Ghislain , Do Ron 
Published: March 2023

Background:Causality between plasma triglyceride (TG) levels and atherosclerotic cardiovascular disease (ASCVD) risk remains controversial despite more than four decades of study and two recent landmark trials, STRENGTH, and REDUCE-IT. Further unclear is the association between TG levels and non-atherosclerotic diseases across organ systems.Methods:Here, we conducted a phenome-wide, two-sample Mendelian randomization (MR) analysis using inverse-variance weighted (IVW) regression to systematically infer the causal effects of plasma TG levels on 2600 disease traits in the European ancestry population of UK Biobank. For replication, we externally tested 221 nominally significant associations (p<0.05) in an independent cohort from FinnGen. To account for potential horizontal pleiotropy and the influence of invalid instrumental variables, we performed sensitivity analyses using MR-Egger regression, weighted median estimator, and MR-PRESSO. Finally, we used multivariable MR (MVMR) controlling for correlated lipid fractions to distinguish the independent effect of plasma TG levels.Results:Our results identified seven disease traits reaching Bonferroni-corrected significance in both the discovery (p<1.92 × 10-5) and replication analyses (p<2.26 × 10-4), suggesting a causal relationship between plasma TG levels and ASCVDs, including coronary artery disease (OR 1.33, 95% CI 1.24–1.43, p=2.47 × 10-13). We also identified 12 disease traits that were Bonferroni-significant in the discovery or replication analysis and at least nominally significant in the other analysis (p<0.05), identifying plasma TG levels as a novel potential risk factor for nine non-ASCVD diseases, including uterine leiomyoma (OR 1.19, 95% CI 1.10–1.29, p=1.17 × 10-5).Conclusions:Taking a phenome-wide, two-sample MR approach, we identified causal associations between plasma TG levels and 19 disease traits across organ systems. Our findings suggest unrealized drug repurposing opportunities or adverse effects related to approved and emerging TG-lowering agents, as well as mechanistic insights for future studies.Funding:RD is supported by the National Institute of General Medical Sciences of the National Institutes of Health (NIH) (R35-GM124836) and the National Heart, Lung, and Blood Institute of the NIH (R01-HL139865 and R01-HL155915).
Improving Handling Systems of Tomato (Solanum lycopersicum) in Cameroon
Authors: Djoukeng Henri Grisseur , Tangka Julius Kewir , Ndaji Nathaniel Tetu , Wafo Chanel Kevin Tokom , Assoumou Whitney Rakelle Anguezomo , Peyoumeya Nestor Lindou 
Published: March 2023

In Cameroon, tomato (Solanum lycopersicum) is among the most important fruits with a consumption of about 35%. A 5-months study was conducted in two tomato production basins, namely Tsinfou and Litieu. This study aims to reduce postharvest losses of tomato for contribute to increase income and standard of living of producers in the Menoua division. The postharvest technics adopted by producers, transporters and traders were identified through investigations and direct observations. The rate loss of tomato and its deterioration over a certain period of time were evaluated. Also, the type, nature and causes of these postharvest losses were determined. The results from this study show that, inappropriate post-harvest technics are practiced in all links of the supply chain. The average rate loss during harvest, transport, conservation is 7.50%, 6.50% and 35.50% respectively. They are caused by mechanical, biological and microbial actions, environmental and socio-economic factors. These losses reduce actor's incomes and the availability of tomatoes on the market, hence the inaccessibility for poor citizens. Avoiding overloading and mixed transport of tomato crates with other products and using planks in lorry to overlap crates to minimize compression are two technics implemented by this study for reduce tomatoes postharvest losses. Establishment of affordable processing and conservation units, qualified workforce and maintaining a good state of roads should be adopted.
Study of the Substitution of Marine Animal Oils in Maggot Flour by Vegetable Oils for the Growth and Larval Survival of African Catfish, Heterobranchus longifilis Valencienne, 1840 in Aquarium
Authors: Kimou N. B. , Tia B. C. , Koné A. , Atsé C. B. , Ouattara I. N. 
Published: March 2023

This study showed clearly the effect of adding palm oil to the diet of farmed fish to replace marine animal oils. For this purpose, four foods based on maggot flour at 35% protein with the incorporation of palm oil, at different levels at 0, 2, 5 and 10% were tested in the to assess their impact on the improved growth performance, food utilization, survival rate and biochemical composition of Heterobranchus longifilis larvae
Four experimental diets were formulated based on the maggot meal as the main protein source. These diets were formulated at 35 % protein levels with maggot meal and maize flour as the major ingredients containing different concentrations of palm oil levels at 0, 2, 5, and 10 %. This study was carried out in the reproduction laboratory, at Oceanological Research Center, Abidjan, Côte d’Ivoire, between the periods of September to November 2022.
The diets were offered to the larvae (average initial weight 0.004 ± 0.001 g) three times a day ad libitum for 49 days. At the end of rearing, the results showed that the different experimental foods distributed did not influence the quality of the rearing environment.
The best growth was obtained with the larvae subjected to diet containing 2% palm oil with a final average weight of 3.21 g and a conversion index of 1.63. Beyond this rate, larval growth decreases. Survival rates vary from 70 to 73 %. The conversion ratios are not significantly different and ranged between 1.63 and 2.3. On the biochemical larvae submitted to diet containing 10 % of palm oil had body lipid content (2 %) and high ash rich. As against a gain of protein is observed with larvae submitted to diets containing 2 % palm oil reflects an effect of protein.
From the present results, diet containing 2 % crude palm oil is considered optimal for Heterobranchus longifilis larvae.
To Study High-sensitivity CRP Levels in Overweight and Obese Individuals
Authors: Kumar Patamsetti Anil , Jha Sumit Kant , Prasad Anand , Jindal Nitesh , Bhandari Sanchit 
Published: March 2023

The present study examines whether overweight and obese are inter related with low-grade systemic inflammation as measured by serum hs-CRP concentration. The present observational, cross-sectional study is from the department of medicine, CSS Hospital, Subharti Medical College, Meerut, to evaluate the profile of patients who came for routine health check-ups from December 2020 to January 2022. The study comprised 150 patients divided into three groups normotensives, normoglycemic adults of the age group 20-70 years based on BMI as Normal BMI (18.5-22.9 kg/m2), overweight (23-24.9 kg/m2) and obese (BMI>25 kg/m2), according to Asian standards by WHO. The mean age among the study subjects was 49.38±12.62 years. Out of 150 subjects, 83 (55.33%) were males and 67 (44.67%) were females. Normal, overweight, and obesity were found among 34%, 29.33%, and 36.67% of the subjects respectively. Normal and high hs-CRP was reported in 46% and 54% of the subjects respectively. The mean hs-CRP among the study subjects was 6.07±4.23. Mean FBS (mg/dL), WC (cm), TC (mg/dL), TGL (mg/dL), and HDL (mg/dL) among the study subjects was 102.94±13.03, 88.2±13.36, 161.84±52.56, 133.18±64.48 and 34.73±17.44 respectively. Mean hs-CRP was found to be highest in obese subjects (10.09±3.67) followed by overweight (6.74±2.48) and normal subjects (2.32±1.11). When hs-CRP was compared among normal vs overweight, normal vs obese, and overweight vs obese using a t-test, a significant difference was found. Pearson correlation analysis revealed a positive correlation between BMI, FBS (mg/dL), WC (cm), TC/HDL (mg/dL), TGL (mg/dL), and hs-CRP i.e. with an increase in these mentioned parameters, hs-CRP value also increases.
Conclusion: Obesity is a state of chronic inflammation that has a strong link to hs-CRP levels.
PENGAYAAN KOSA KATA BAHASA INGGRIS UNTUK PELAJAR USIA MUDA MENGGUNAKAN METODE TOTAL PHYSICAL RESPONSE (TPR)
Authors: Marina Marina , Rasyimah Rasyimah , Sari Dewi Kumala , Kurniawati Kurniawati 
Published: March 2023

Program Pengabdian kepada Masyarakat ini dilaksanakan di Madrasah Ibtidaiyah Swasta (MIS) Meuraksa yang terletak di Desa Jambo Timu Kecamatan Blang Mangat Kota Lhokseumawe Aceh. Tujuan program ini yaitu untuk meningkatkan penguasaan kosa kata bahasa Inggris yang dimiliki oleh para pelajar dan menyediakan kesempatan untuk mempraktekkan kosa kata yang sudah mereka pelajari. Para pelajar ini belum memiliki kemampuan berbahasa Inggris yang memadai dikarenakan pihak sekolah belum memberikan pendidikan Bahasa Inggris secara formal. Hal ini mengakibatkan timbulnya permasalahan dimana penguasaan bahasa Inggris mereka belumlah mencapai tingkat yang cukup baik disebabkan penguasaan kosa kata yang masih rendah. Oleh karena itu sangatlah penting bagi mereka untuk mendapatkan pelatihan pengayaan kosa kata agar terjadi peningkatan penguasaan kosa kata. Sebagai solusi dari permasalahan yang dihadapi para pelajar ini, maka perlu diadakan pelatihan pengayaan kosa kata dengan menggunakan metode Total Physical Response (TPR). Metode TPR merupakan metode untuk pengajaran bahasa yang dalam penerapannya menggabungkan koordinasi perintah, ucapan dan gerak sehingga lebih mudah untuk menguasai suatu bahasa dalam pembelajarannya. Selain itu, kesempatan untuk mempraktekkan kosa kata yang sudah dipelajari juga diberikan dalam bentuk praktek pengucapan dan penulisan. Metode pelaksanaan dalam pelatihan ini meliputi (1) pengayaan kosa kata melalui metode TPR; (2) pelatihan pembalikan peran, dan (3) pelatihan urutan tindakan untuk mempraktekkan kosa kata yang sudah dipelajari. Dari kegiatan ini penguasaan kosa kata yang meningkat dapat membantu mereka dalam proses belajar di sekolah.
Predicting micronutrient deficiency with publicly available satellite data
Authors: Bondi‐Kelly Elizabeth , Chen Haipeng , Golden Christopher D. , Behari Nikhil , Tambe Milind 
Published: March 2023

AbstractMicronutrient deficiency (MND), which is a form of malnutrition that can have serious health consequences, is difficult to diagnose in early stages without blood draws, which are expensive and time‐consuming to collect and process. It is even more difficult at a public health scale seeking to identify regions at higher risk of MND. To provide data more widely and frequently, we propose an accurate, scalable, low‐cost, and interpretable regional‐level MND prediction system. Specifically, our work is the first to use satellite data, such as forest cover, weather, and presence of water, to predict deficiency of micronutrients such as iron, Vitamin B12, and Vitamin A, directly from their biomarkers. We use real‐world, ground truth biomarker data collected from four different regions across Madagascar for training, and demonstrate that satellite data are viable for predicting regional‐level MND, surprisingly exceeding the performance of baseline predictions based only on survey responses. Our method could be broadly applied to other countries where satellite data are available, and potentially create high societal impact if these predictions are used by policy makers, public health officials, or healthcare providers.
Inkjet Printing Flexible Thermoelectric Devices Using Metal Chalcogenide Nanowires
Authors: Du Jingjie , Zhang Botao , Jiang Meng , Zhang Qihao , Zhang Keyi , Liu Yan , Wang Lianjun , Jiang Wan 
Published: March 2023

AbstractDevelopment of flexible thermoelectric devices offers exciting opportunities for wearable applications in consumer electronics, healthcare, human–machine interface, etc. Despite the increased interests and efforts in nanotechnology‐enabled flexible thermoelectrics, translating the superior properties of thermoelectric materials from nanoscale to macroscale and reducing the manufacturing costs at the device level remain a major challenge. Here, an economic and scalable inkjet printing method is reported to fabricate high‐performance flexible thermoelectric devices. A general templated‐directed chemical transformation process is employed to synthesize several types of 1D metal chalcogenide nanowires (e.g., Ag2Te, Cu7Te4, and Bi2Te2.7Se0.3). These nanowires are made into inks suitable for inkjet printing by dispersing them in ethanol without any additives. As a showcase for thermoelectric applications, fully inkjet‐printed Ag2Te‐based flexible films and devices are prepared. The printed films exhibit a power factor of 493.8 µW m−1 K−2 at 400 K and the printed devices demonstrate a maximum power density of 0.9 µW cm−2 K−2, both of which are significantly higher than those reported in state‐of‐the‐art inkjet‐printed thermoelectrics. The protocols of metal chalcogenide ink formulations, as well as printing are general and extendable to a wider range of material systems, suggesting the great potential of this printing platform for scalable manufacturing of next‐generation, high‐performance flexible thermoelectric devices.
Bio‐inspired Porous Composite Electrode for Enhanced Mass Transfer and Electrochemical Water Purification by Modifying Local Flow Pattern
Authors: Yu Yuan , Pei Shuzhao , Zhang Jinna , Ren Nanqi , You Shijie 
Published: March 2023

AbstractPorous electrodes offer a new opportunity for flow‐through electrochemical water purification, but their irregular porous‐structure makes the local flow pattern and mass transfer performance inhomogeneous, unpredictable, and uncontrollable. In this study, a bio‐inspired design is reported for porous electrode by learning the micro‐scale architectures of the wings of butterfly and owl based on analogy between heterogeneous mass transfer and sound absorption. Results demonstrate that combining gyroid and perforated plate can produce strong periodic vortex and inertial flow in interpenetrating channels even at laminar flow region. This enables homogeneous, predictable and controllable flow patterns and enhanced mass transfer, which can be explained by uniformity analysis and physical field synergy. Based on experimental tests on Cu electrode fabricated by selective laser melting, the composite gyroid electrode generates the limiting current density of 83% higher than random porous‐structured electrode, accounting for nitrate removal as high as 95% by electrochemical denitrification. This study represents a paradigm shift to advance design for porous architectures by learning experiences of hydrodynamic behaviors from nature. In this way, it is feasible to enhance mass transfer by modifying local flow patterns on pore scale, which may have broader implications that extend to other heterogeneous reaction systems.
Cell‐Reprogramming‐Inspired Dynamically Responsive Hydrogel Boosts the Induction of Pluripotency via Phase‐Separated Biomolecular Condensates
Authors: Zhu Fei , Yan Na , Lu Xukun , Xu Junchao , Gu Haiyan , Liang Jie , Cheng Keman , Wang Xiaona , Ma Xiaotu , Ma Nana , Zhao Xiao , Chen Chunying , Nie Guangjun 
Published: March 2023

AbstractInduced pluripotent stem cells (iPSCs) have wide applications in disease modeling, personalized medicine, and tissue engineering. The generation of iPSCs from somatic cells via transcriptional‐factor‐ or chemical molecule‐based approaches are time‐consuming and inefficient. Here, a cell‐reprogramming‐inspired dynamically responsive hydrogel is fabricated via a synthetic‐biology‐based strategy. Human and mouse somatic cells (including senescent cells) are efficiently reprogrammed into iPSCs that exhibit key features of embryonic stem cells. The cell‐reprogramming‐responsive hydrogel possesses dynamic bioresponsiveness, and it faithfully senses metabolic remodeling and extracellular acidification during cell reprogramming, responding by changing its mechanical properties accordingly. Mechanistic study demonstrates that the autonomous change of the mechanical properties of the cell‐reprogramming‐responsive hydrogel elicits the formation of Yes‐associated protein (YAP) biomolecular condensates with the appropriate timing during cell reprogramming, ensuring a faster and more efficient generation of iPSCs than conventional cell reprogramming approach. Taken together, this study reveals the robust induction of pluripotency by coordination of cell‐reprogramming‐inspired dynamically responsive hydrogel and phase‐separated biomolecular condensates.
Skeletal Network Enabling New‐Generation Thermoplastic Vulcanizates
Authors: Yu Shuangjian , Wu Siwu , Fang Shifeng , Tang Zhenghai , Zhang Liqun , Guo Baochun 
Published: March 2023

AbstractUpcycling of cross‐linked rubbers is pressing. The introduction of dynamic covalent bonds into the networks is a popular tactic for recycling thermosetting polymers, but it is very challenging to integrate engineering performance and continuous yet stable reprocessability. Based on traditional rubber formulations, herein, a straightforward strategy is presented for constructing a skeletal network (SN) through interfacial crosslinking and percolation of rubbery granules in a rubber matrix. Rapid exchange reactions involving dynamic interfacial sulfides realize repeated “fragmentation and healing” in the solid‐state and consequent reconfiguration of the SN topology of the elastomer, thus endowing the resultant SN elastomer with continuous yet stable re‐extrudability. These SN elastomers with hierarchical structures exhibit high gel contents, high resilience, low creep, and reinforcibility competitive to traditional vulcanizates. Specifically, SN elastomers exhibit better overall performance than commercial thermoplastic vulcanizates (TPVs) materials. Overall, a new concept of thermoplastic vulcanizates is proposed, which will promote the sustainable development of rubbers.
g‐C3N4 Monolayer/2D Mica Nanohybrids with Highly Effective UV–HEV‐Screening Function
Authors: Piao Huiyan , Choi Goeun , Rejinold N. Sanoj , Vinu Ajayan , Choy Jin‐Ho 
Published: March 2023

AbstractExcessive exposure to ultraviolet (UV) and high‐energy visible (HEV) light can cause sunburns, wrinkles, and even skin cancer. Therefore, the development of effective UV–HEV‐shielding agents is of great importance to human health. In this study, semiconducting graphitic carbon nitride (g‐C3N4) is incorporated into the interlayer space of mica through the intercalation of cyanamide and subsequent pyrolysis reactions to form a semiconductor–insulator nanohybrid, namely g‐C3N4–mica, with a 1:1 heterostructure. The g‐C3N4–mica nanohybrid exhibits excellent UV–HEV absorption properties below 450 nm, and its photocatalytic activity is quenched owing to the effective screening of photocatalytic active sites by the insulating mica. It is strongly believed that the proposed g‐C3N4–mica nanohybrid can be applied as a UV–HEV blocking agent owing to its excellent UV–HEV (200–450 nm)‐screening property without any photocatalytic effect or phototoxicity.
Trilayered Block Copolymer Nanostructures Formed by an Iterative Layering Strategy
Authors: Argudo Pablo G. , Demazy Nils , Fleury Guillaume 
Published: March 2023

AbstractNanostructured block copolymer (BCP) thin films enable the formation on‐demand of a variety of periodic patterns at the nanometer scale by tuning the macromolecular BCP characteristics and annealing processes. Significant progress in the control of the self‐assembly has been witnessed over the past decade with the implementation of robust directed self‐assembly methods. However, the self‐assembled structural patterns obtained at equilibrium are limited and methods to expand the range of structural configurations are required to harness additional functionalities. Here, this work demonstrates how polystyrene‐b‐poly(methyl methacrylate) BCP thin layers can be stacked to produce a library of complex 3D hierarchical heterostructures. In this iterative assembly process based on simple building bricks (i.e., immobilized BCP patterns forming Holes, Lines and Dots), the stacking configuration (i.e., self‐assembly and registration) of a BCP thin film is directed with respect to the previous layer using confinement effects and interfacial energy tuning. This responsive layering can lead to intricate 3D Al2O3 structures and opens the way to a broad variety of structural designs toward functional applications.