bluuebunny/crossref_metadata_2025_split huggingface dataset:
IGFL2‐AS1‐induced suppression of HIF‐1α degradation promotes cell proliferation and invasion in colorectal cancer by upregulating CA9
Authors: Qin Mengdi , Liu Qiang , Yang Wei , Wang Qiaofeng , Xiang Zheng 
Published: December 2022

AbstractPurposeThe lncRNA IGFL2‐AS1 is a known cancer‐promoting factor in colorectal cancer (CRC); nonetheless, the mechanism of its carcinogenic effects has not yet been elucidated. This study elaborated on the role and underlying molecular mechanism of IGFL2‐AS1 in promoting CRC cell functions.MethodsIGLF2‐AS1 expression levels in CRC tissue/normal tissue and CRC cell line/normal colon epithelial cell line were detected by quantitative real‐time polymerase chain reaction. Cell counting kit‐8, colony formation assay, and EdU assay were performed to assess the effect of IGFL2‐AS1 knockdown or overexpression on the proliferative capacity of CRC cells. The migration and invasion abilities of LoVo cells were measured using transwell assay. The expression relationship between IGFL2‐AS1 and carbonic anhydrase 9 (CA9) and the CA9 expression level in CRC tissues and cells was verified by transcriptome sequencing, western blotting, and immunohistochemical staining. Treatment with MG132 and cycloheximide was utilized to explore the mechanism by which IGFL2‐AS1 affects the hypoxia‐inducible factor‐1α (HIF‐1α)/CA9 pathway. A nude mouse xenograft model was constructed to evaluate the effect of IGFL2‐AS1 on CRC growth in vivo.ResultsWe discovered that IGFL2‐AS1 was highly upregulated in CRC tumor tissues and cells. IGFL2‐AS1 can functionally promote CRC cell proliferation, migration, and invasion in vitro and accelerate CRC occurrence in vivo. Mechanistic studies demonstrated that IGFL2‐AS1 upregulated the CA9 level by affecting the degradation pathway of HIF‐1α, which elucidates its pro‐proliferative effect in CRC. The lncRNA IGFL2‐AS1 mediated the inhibition of HIF‐1α degradation in CRC and increased CA9 expression, thereby promoting CRC progression.ConclusionOur findings suggested that IGFL2‐AS1 is expected to be a promising new diagnostic marker and therapeutic target for CRC.
Fat‐poor leiomyomatous angiomyolipoma arising from renal parenchyma negative for HMB‐45: A case report
Authors: Kobayashi Yasuyuki , Shimizu Shigeki , Arai Hiroki , Yoshida Kyotaro , Honda Masahito 
Published: December 2022

AbstractFat‐poor leiomyomatous angiomyolipoma, which is similar to smooth muscle tumors, is positive for smooth muscle markers and melanocytic marker human melanin black 45 (HMB‐45). We report a case of fat‐poor leiomyomatous angiomyolipoma arising from renal parenchyma negative for HMB‐45 diagnosed by combined staining with melanocytic markers HMB‐45 and Melan‐A.
Neurologic complications of breast cancer
Authors: Atkins Sarah L. P. , Zimmer Alexandra S. 
Published: December 2022

AbstractBreast cancer is a heterogeneous disease with unique neurologic complications that can arise from central nervous system (CNS) involvement or secondary to treatments themselves. As progress is made, with more targeted therapies and combinations available, particularly in the realm of human epidermal growth factor receptor 2 (HER2)‐positive disease, the role of these new agents in patients with CNS disease is gradually evolving, although intracranial efficacy itself is lagging. At the same time, both systemic and local standard therapies pose clinical challenges regarding neurologic complications, such as peripheral neuropathy and cognitive changes. The development of new agents, such as immunotherapy, and new strategies, such as incorporating systemic therapies into local therapy, unveil new presentations of neurological complications.
A body‐driven rail‐to‐rail 0.3 V operational transconductance amplifier exploiting current gain stages
Authors: Della Sala Riccardo , Centurelli Francesco , Monsurrò Pietro , Scotti Giuseppe , Trifiletti Alessandro 
Published: December 2022

SummaryThis paper presents a novel topology of ultra‐low voltage (ULV) operational transconductance amplifier (OTA), which exploits several design techniques to achieve high efficiency, symmetrical slew rate, good linearity, and robustness in spite of ultra‐low voltage operation. Simulations in a commercial 130‐nm CMOS technology with 0.3‐V supply voltage show the best reported small‐signal figure‐of‐merit among 0.3‐V OTAs, with a dc gain of 56.2 dB, a unity‐gain frequency of 26.2 kHz over a 150‐pF load capacitor, and a power consumption of 139.5 nW. A symmetrical slew rate of about 3.2 V/ms is achieved, and results are consistent under process, supply voltage and temperature variations, and device mismatches.
Enhancing voltage regulation using 5‐level TCHB based DVR in radial secondary distribution feeder system
Authors: Manmadha Rao Singamasetty , Satputaley Rajshree Jithendra , Patne Nita R. , Raghava Bathula Venkata Surya 
Published: December 2022

SummaryThe voltage quality issues shows the significant effect on the performance of radial secondary distribution feeder. This paper aims to enhance the voltage regulation of radial secondary distribution feeder system using 5‐level TCHB inverter based dynamic voltage restorer. Series voltage drop is the major factor causes poor voltage regulation. A 5‐level TCHB inverter based DVR is used to inject the same amount of voltage dropped by series impedance. The DVR injects voltage with proper magnitude, phase and frequency with the proposed single phase PLL based SRF control circuitry. This enhances the voltage regulation by maintaining the load voltage at its rated value. Both the simulation and hardware results shows the enhancement of voltage regulation with mitigation using DVR.
Transient electrophoresis of a spherical colloidal particle with a slip surface
Authors: Ohshima Hiroyuki 
Published: December 2022

AbstractWe derive the general expression for the transient electrophoretic mobility of a spherical colloidal particle with a slip surface in an electrolyte solution. From the general mobility expression, we derive an analytic mobility expression, which is applicable for low particle zeta potentials and arbitrary Debye length. This expression corresponds to the time‐dependent transient Henry function.
Observations and modeling of shear stress reduction and sediment flux within sparse dune grass canopies on managed coastal dunes
Authors: Dickey John , Wengrove Meagan , Cohn Nicholas , Ruggiero Peter , Hacker Sally D. 
Published: December 2022

AbstractWind flow over coastal foredunes adapts to vegetation, resulting in spatial gradients in bed shear stresses that contribute to the formation of localized bedforms. Understanding, and having the capability to numerically predict, the distribution of sediment deposited within sparsely vegetated dune complexes is critical for quantifying the ecological, protective, and economic benefits of dune management activities. Data from wind tunnel experiments have indicated that there is a spatial lag from the canopy leading edge to a downwind location where sediment deposition first occurs. The length scale of this deposition lag is further quantified here using new field measurements of aeolian sediment transport across sparsely vegetated managed dune systems in Oregon, USA. We develop a deposition lag length scale parameter using both lab and this new field data and then incorporate this parameter into the process‐based aeolian sediment transport model, Aeolis, which also includes a new far‐field shear stress coupler. Results from numerical simulations suggest that the spatial deposition lag effect is significant for model skill in sparsely vegetated dunes. We observe with field and laboratory observations that, as canopy density increases, the length of the deposition lag decreases. As such, within the model framework the implementation of the deposition lag length does not affect the results of models of coastal dune geomorphological evolution within higher density canopies. Dune canopy density can vary due to natural (e.g., storm overwash, burial, die‐off) or anthropogenic (e.g., managed plantings, dune grading) processes.
Thermophysical studies, corrosion analysis, and discharging characteristics of lauryl alcohol/lauric acid eutectic mixture as a potential phase change material for human comfort applications
Authors: Vadakkan Sharooque , M. T. Abhijith , Sreekumar A. 
Published: December 2022

AbstractClimate change has been identified as the greatest threat of the 21st century. Recently, many cities around the world recorded their highest ever temperatures as a result of heat waves, negatively impacting several communities and livelihoods. Due to this warmer environment around the world, there has been a tremendous increase in cooling energy requirements in the last decade, particularly for human thermal comfort. It is critical to accelerate studies based on latent heat storage systems for personal comfort applications such as cooling vests that can maintain the human body temperature at a comfortable level in hot climates, which will eventually reduce the dependency of fossil fuel based energy resources to a certain extent. The purpose of this study is to conduct a thorough examination of the thermophysical properties of a eutectic phase change material (PCM) developed, which is comprised of lauryl alcohol and lauric acid, as a viable contender for human cooling applications. The melting temperature and latent heat of fusion of the eutectic combination were discovered to be 13.13°C and 164.23 J g−1, respectively, via differential scanning calorimetry (DSC). Four important thermophysical properties: thermal cycling, thermogravimetric analysis, Fourier transform infrared spectroscopy, and thermal conductivity studies were conducted, and the results obtained ascertain the material's suitability for the intended application. Based on corrosion studies, stainless steel and aluminum are particularly suited for fabricating the metal containers for the developed PCM. The results of the discharging studies of the chosen PCM in the vapor absorption refrigeration chamber appear promising as well.
An Ecostructural Lens for Health Ethics
Authors: Eckenwiler Lisa 
Published: December 2022

AbstractIn this commentary, I describe an ecostructural approach to health ethics, which is grounded in a conception of people as ecological subjects and privileges place in supporting health and health justice. This approach sees people as dwelling in health ecosystems that can support or undermine health, and it situates us in social norms and processes, with a particular concern for structural health injustice. In patient care, an ecostructural approach can be operationalized by attending to conditions in the sites where birthing, healing, and dying take place and by critiquing their economic structures. For public health, relationships between people, animals, land, the built environment, and climate demand attention, as do racist norms and economic processes that thwart health justice. For global health, an ecostructural approach might envision a revolution in governance that challenges nationalism, in which health systems treat citizens while depending on human resources supplied through structures that sustain health injustice.
Stories and Shame in Front‐Line Medicine
Authors: Frank Arthur W. 
Published: December 2022

AbstractThis review of Jay Baruch's Tornado of Life: A Doctor's Journey through Constraints and Creativity in the ER considers the book's contributions, including its explorations of the clinical dilemma of working with patients’ stories that are fragmented, how easily clinicians can miss crucial parts of patients’ stories and how that affects care, and the “agonizing compromises” between what patients need and what institutions can provide. Baruch acknowledges, without any self‐indulgence, the shame that his work causes him, given the limitations of what he can do.
A case study of an academic‐stakeholder partnership: Evaluation of the ‘10 000 Lives’ smoking cessation health promotion program
Authors: Khan Arifuzzaman , Green Kalie , Khandaker Gulam , Lawler Sheleigh , Gartner Coral 
Published: December 2022

AbstractIssue AddressedIn Australia, smoking prevalence is higher in regional areas than in metropolitan cities; Central Queensland, a central‐east district of Queensland, has substantially higher smoking rates than the state average. In November 2017, Central Queensland Public Health Unit (CQPHU) launched the ‘10 000 Lives’ initiative to reduce the smoking prevalence in the region. The initiative partnered with local hospitals and community organisations to increase the uptake of interventions like Quitline in the region. Evaluating a program like ‘10 000 Lives’ is critical for evidence‐based health promotion practice. CQPHU partnered with a large metropolitan Australian university to evaluate the ‘10 000 Lives’ through a scheme that provided a stipend for a Doctor of Philosophy (PhD) student.MethodsThis narrative report describes the experience of evaluating ‘10 000 Lives’ in a collaborative partnership between CQPHU and the public health academia.ResultsA PhD student was recruited to join this collaboration, and both developed a program logic model and completed a process and impact evaluation. This evaluation provided an ideal ‘living’ case study to embed in the Master of Public Health curriculum and provided the PhD student with teaching experience delivering a demonstration of public health in practice.ConclusionThe collaboration project was highly successful, exemplifying research, learning and practical integration for all partners.So What?The partnership demonstrated how universities can work with government health agencies to build practice‐based evidence, and importantly give public health students authentic learning opportunities.
Retrospective multicenter registry for endovascular treatment with newer devices in over 25‐cm femoropopliteal artery disease: A retrospective observational study
Authors: Horie Kazunori , Takahara Mitsuyoshi , Nakama Tatsuya , Tanaka Akiko , Tobita Kazuki , Hayakawa Naoki , Mori Shinsuke , Iwata Yo , Suzuki Kenji 
Published: December 2022

AbstractBackground and AimsEndovascular therapy (EVT) is recommended in femoropopliteal (FP) lesions shorter than 25 cm by current guidelines; however, diffuse FP lesions remains challenging for EVT. The aim of this study was to investigate the efficacy of EVT with the latest devices for FP lesions longer than 25 cm.MethodsThis retrospective multicenter registry analyzed patients presented peripheral artery disease (PAD) having FP lesions longer than 25 cm who underwent EVT using the latest devices between 2017 and 2021. The primary outcome was restenosis 1 year after EVT.ResultsThe present study enrolled a total of 504 PAD patients with 614 lesions undergoing EVT for diffuse FP lesions. The Kaplan–Meier analysis showed that the rates of freedom from restenosis and clinically‐driven target lesion revascularization were 79.3% and 82.4% 1 year after EVT, respectively. The multivariate Cox proportional hazards regression analysis showed that clinical features associated independently with restenosis risk were cilostazol use (adjusted hazard ratio, 0.49 [0.32–0.74]; p = 0.001), reference vessel diameter (RVD) (0.72 [0.58–0.89] per 1‐mm increase; p = 0.002), and P3 segment involvement (2.08 [1.33–3.26]; p = 0.001). The Kaplan–Meier analysis was conducted to compare the primary patency between cases with and without a small RVD, P3 involvement, and/or lack of cilostazol; any risk factors were related to a worse primary patency rate, compared with cases without risk factors.ConclusionIn the current EVT era, the primary patency at 1 year was acceptable at 79.3% in patients with FP lesions longer than 25 cm. A small vessel and P3 segment involvement might be associated with a poor 1‐year patency rate after EVT, whereas cilostazol administration might contribute to reducing restenosis.
Spatiotemporal evolution of aeolian dust in China: An insight into the synoptic records of 1984–2020 and nationwide practices to combat desertification
Authors: Zhang Xiao‐Xiao , Lei Jia‐Qiang , Wu Shi‐Xin , Li Sheng‐Yu , Liu Lian‐You , Wang Zi‐Fa , Huang Shuang‐Yan , Guo Yu‐Hong , Wang Yong‐Dong , Tang Xiao , Zhou Jie 
Published: December 2022

AbstractAeolian dust is closely related to land degradation, desertification, and sand and dust storm weather, and is a significant factor influencing the Earth's biogeochemical cycles. Here we present an investigation of the recent synoptic features of atmospheric dust in China and analyze its spatiotemporal change based upon meteorological observation data and satellite products. It shows that aeolian dust frequency in China has decreased gradually from 1984 to 2020. The outbreak frequency of dust storms declined significantly by 97.7%, followed by severe dust storm, dust in suspension, and blowing dust with 88.8%, 75%, and 64.3% reduction, respectively. The main dust sources influencing China are the Mongolian Gobi Desert, the Taklimakan Desert, the Hexi Corridor, the Alxa Plateau Desert, the Qaidam basin Desert, and the northeast‐southwest stretching semiarid farming‐pasture ecotone. Atlantic multidecadal oscillation (AMO) and Pacific decadal oscillation (PDO) may play an important role in teleconnection with aeolian dust event occurrence in China. Their correlation coefficients are −0.6 and 0.37, respectively. For more than 40 years, China has made huge investments in ecological restoration projects, and enacted national policies and laws to mitigate desertification. Significant environmental improvement has consequently ensued in China in the early 21st century, and the aeolian dust events were reduced to a record minimum in 2020. In contrast to the growing nationwide greenness, China is now facing up to an incremental dust risk generated from extraterritorial source regions such as the Mongolian Gobi Desert and Central Asian desiccated salt lakes.
Establishing a Cystic Fibrosis Learning Network: Interventions to promote collaboration and data‐driven improvement at scale
Authors: Ong Thida , Albon Dana , Amin Raouf S. , Bailey Julianna , Bandla Srujana , Britto Maria T. , Flath Jonathan , Gamel Breck , Powers Michael , Sabadosa Kathryn A. , Saulitis Anna K. , Thomas Lacrecia K. , Thurmond Sophia , Seid Michael ,   the Cystic Fibrosis Learning Network
Published: December 2022

AbstractIntroductionA learning health network is a type of learning health system in which stakeholders use network organization to improve health and health care. Building on existing resources in the cystic fibrosis (CF) community, the Cystic Fibrosis Learning Network (CFLN) was designed to improve medical outcomes and quality of life through an intentional focus on achieving reliable evidence‐based chronic care delivery and creating a system for data‐driven collaborative learning.MethodsWe describe the development and growth of the CFLN considering six domains of a Network Maturity Grid: system leadership; governance and policy management; quality improvement (QI); engagement and community building; data and analytics; and research. We illustrate the impact of the CFLN experience on chronic care processes and indicators of collaborative infrastructure.ResultsThe CFLN represents 36 accredited care centers in the CF Foundation Care Center Network caring for over 6300 patients. Of 6779 patient clinical care visits/quarter, 77% are entered into the CF Foundation Patient Registry within 30 days, providing timely means to track outcomes. Collaborative visit planning is occurring in 93% of clinical care visits to share agenda setting with patients and families. Almost all CFLN teams (94%, n = 34) have a patient/family partner (PFP), and 74% of PFPs indicate they are actively participating, taking ownership of, or leading QI initiatives with the interdisciplinary care team. In 2022, 97% of centers reported completing 1–13 improvement cycles per month, and 82% contributed to monthly QI progress reports to share learning.ConclusionThe CFLN is a maturing, collaborative infrastructure. CFLN centers practice at an advanced level of coproduction. The CFLN fosters interdisciplinary and PFP leadership and the performance of consistent data‐driven improvement cycles. CFLN centers are positioned to respond to rapid changes in evidence‐based care and advance the practice of QI and implementation science on a broader scale.
Ex vivo 100 μm isotropic diffusion MRI‐based tractography of connectivity changes in the end‐stage R6/2 mouse model of Huntington's disease
Authors: Manivannan Ashwinee , Foley Lesley M. , Hitchens T. Kevin , Rattray Ivan , Bates Gillian P. , Modo Michel 
Published: December 2022

AbstractBackgroundHuntington's disease is a progressive neurodegenerative disorder. Brain atrophy, as measured by volumetric magnetic resonance imaging (MRI), is a downstream consequence of neurodegeneration, but microstructural changes within brain tissue are expected to precede this volumetric decline. The tissue microstructure can be assayed non‐invasively using diffusion MRI, which also allows a tractographic analysis of brain connectivity.MethodsWe here used ex vivo diffusion MRI (11.7 T) to measure microstructural changes in different brain regions of end‐stage (14 weeks of age) wild type and R6/2 mice (male and female) modeling Huntington's disease. To probe the microstructure of different brain regions, reduce partial volume effects and measure connectivity between different regions, a 100 μm isotropic voxel resolution was acquired.ResultsAlthough fractional anisotropy did not reveal any difference between wild‐type controls and R6/2 mice, mean, axial, and radial diffusivity were increased in female R6/2 mice and decreased in male R6/2 mice. Whole brain streamlines were only reduced in male R6/2 mice, but streamline density was increased. Region‐to‐region tractography indicated reductions in connectivity between the cortex, hippocampus, and thalamus with the striatum, as well as within the basal ganglia (striatum—globus pallidus—subthalamic nucleus—substantia nigra—thalamus).ConclusionsBiological sex and left/right hemisphere affected tractographic results, potentially reflecting different stages of disease progression. This proof‐of‐principle study indicates that diffusion MRI and tractography potentially provide novel biomarkers that connect volumetric changes across different brain regions. In a translation setting, these measurements constitute a novel tool to assess the therapeutic impact of interventions such as neuroprotective agents in transgenic models, as well as patients with Huntington's disease.
Validation of the humour styles questionnaire in healthcare professionals
Authors: Leñero‐Cirujano Miriam , Torres‐González Juan Ignacio , González‐Ordi Héctor , Gómez‐Higuera Jacinto , Moro‐Tejedor Mª Nieves 
Published: December 2022

AbstractAimThe aim of this study is to determine the reliability and validity of the Humour Styles Questionnaire (HSQ) in a sample of Spanish healthcare professionals.DesignA cross‐sectional study.MethodsThe version of HSQ translated into Spanish by Cayssials and Pérez was used to validate on a sample of healthcare professionals (N = 250). The reliability analysed the Crombach's α coefficient and Pearson's correlation coefficient between the factors and the total scale score. The Exploratory Factor Analysis was carried out with Kaiser's criteria for the extraction of factors with Varimax rotation.ResultsHSQ in this study sample reproduced the similar structure of the original version with four factors (affiliative, self‐enhancing, aggressive and self‐defeating humour). These factors explained 44.46% of the total variance and Cronbach's ranged from 0.64–0.79. Global HSQ scale reliability was 0.82.ConclusionThe HSQ is a valid and reliable instrument for assessing humour in healthcare professionals.