bluuebunny/crossref_metadata_2025_split huggingface dataset:
A call for safety: Anticipating and mitigating risk across an obstetrics and gynecology service line
Authors: Combs Adriann , Klein Victor R. 
Published: May 2023

AbstractDelivery of healthcare is a complex interaction of patients, healthcare providers, nurses, ambulatory practices, and hospitals. As the model of health care transitioned, free standing physician practices and hospitals have coalesced to form networks of ambulatory practices and hospitals. This change in the model of healthcare delivery presented challenges to provide safe, quality, cost‐effective care for patients, with potentially increased risk to an organization. The development and imbedding of comprehensive safety strategies are imperative to the foundation of this model.Northwell Health, a large health system in the northeastern United States developed a strategy for their Obstetrics and Gynecology Service Line which includes weekly interaction by departmental leadership from each hospital to discuss operations, share concerns and identify potential opportunities to prevent recurrent suboptimal outcomes and improve patient safety. The weekly Safety Call, described in this article is a component of the safety and quality program that has contributed to a 19% decrease in the Weighted Adverse Outcomes Index for the 10 maternity hospitals delivering over 30,000 babies annually within the system since inception. There was also a significant reduction in insurance premiums based on actuarial projections of risk reduction because of the implementation of an Obstetrical Safety Program.
Presymptomatic viral shedding in high‐risk mpox contacts: A prospective cohort study
Authors: Brosius Isabel , Van Dijck Christophe , Coppens Jasmine , Vandenhove Leen , Bangwen Eugene , Vanroye Fien , Verschueren Jacob ,   The ITM MPOX Study Group, Zange Sabine , Bugert Joachim , Michiels Johan , Bottieau Emmanuel , Soentjens Patrick , van Griensven Johan , Kenyon Chris , Ariën Kevin K. , Van Esbroeck Marjan , Vercauteren Koen , Liesenborghs Laurens 
Published: May 2023

AbstractThe risk of infection after exposure to clade IIb mpox virus (MPXV) is unknown, and potential presymptomatic shedding of MPXV remains to be demonstrated. High‐risk contacts of mpox patients were followed‐up in a prospective longitudinal cohort study. Individuals reporting sexual contact, >15 min skin‐to‐skin contact, or living in the same household with an mpox patient were recruited in a sexual health clinic in Antwerp, Belgium. Participants kept a symptom diary, performed daily self‐sampling (anorectal, genital, and saliva), and presented for weekly clinic visits for physical examination and sampling (blood and oropharyngeal). Samples were tested for MPXV by PCR. Between June 24 and July 31, 2022, 25 contacts were included, of which 12/18 (66.0%) sexual and 1/7 (14.0%) nonsexual contacts showed evidence of infection by MPXV‐PCR. Six cases had typical mpox symptoms. Viral DNA was detected as early as 4 days before symptom onset in 5 of them. In 3 of these cases, replication‐competent virus was demonstrated in the presymptomatic phase. These findings confirm the existence of presymptomatic shedding of replication‐competent MPXV and emphasize the high risk of transmission during sexual contact. Sexual contacts of mpox cases should abstain from sex during the incubation period, irrespective of symptoms.
Effects of dynamization timing and degree on bone healing of different fracture types
Authors: Fu Ruisen , Liu Yang , Song Fei , Fu Jizhi , Du Tianming , Liu Youjun , Willie Bettina M. , Yang Haisheng 
Published: May 2023

AbstractDynamization, that is, increasing interfragmentary movement (IFM) by reducing fixation stiffness from a rigid to a more flexible state, has been successfully used in clinical practice to promote fracture healing. However, it remains unclear how dynamization timing and degree affect bone healing of different fracture types. Finite element models of tibial fractures based on the OTA/AO classification (Simple: A1‐Spiral, A2‐Oblique, A3‐Transverse; Wedge: B2‐Spiral, B3‐Fragmented; Complex: C2‐Segment, C3‐Irregular), in combination with fuzzy logic‐based mechano‐regulatory tissue differentiation algorithms, were used to simulate the healing process when dynamization of varied degrees (dynamization coefficient or DC = 0‐0.9; 0.9 represents 90% reduction in the fixation stiffness relative to a rigid fixation) were applied at different time points after fracture. The fuzzy logic‐based algorithms have been validated with a preclinical animal model. The results showed that the healing responses of type A fractures were more sensitive to the changes in dynamization degree and timing comparing with type B or C fractures. Additionally, the optimal dynamization regime for each fracture type was different. For type A fractures, a moderate dynamization degree (e.g., DC = 0.5) applied after Week 1 promoted the recovery of biomechanical integrity. For type B and C fractures, the effective dynamization included a greater dynamization degree (DC = 0.7) applied after Week 2. Our results further demonstrated that the fracture morphology affected interfragmentary strain environments within the callus, leading to varied healing results for different fracture types. These results suggest that the effects of dynamization are highly dependent of the fracture types. Therefore, specific dynamization strategies should be chosen for different fracture types to achieve optimal healing outcomes.
Wideband subterahertz antenna based on the symmetrical path‐length lens for sidelobe level reduction
Authors: Xiong Qi , Ye Jia , Pan Wei , Yan Lian‐shan 
Published: May 2023

AbstractThis letter presents a high‐gain fully metallic antenna designed with a symmetrical path‐length lens for subterahertz applications over a wide frequency range. The symmetrical path‐length lens divides the E‐plane horn into two symmetrical halves, which can compensate for the phase difference generated by the E‐plane horn individually. Compared to the conventional asymmetrical path‐length lens, the numerical results show the sidelobe level (SLL) can be reduced from −11 to −15.7 dB with the symmetrical path‐length lens. Measured results show the proposed antenna exhibits a reflection coefficient of less than −10 dB from 110 to 170 GHz. In addition, the measured SLL is about −15 dB at 140 GHz. The measured results indicate that the symmetrical path‐length metallic lens is an effective way to improve the poor lobe suppression resulting from an asymmetrical path‐length lens.
Are clinical outcomes associated with baseline sensory profiles in people with musculoskeletal shoulder pain? Protocol for a prospective longitudinal observational study
Authors: Hollis Danielle , Mendis M. Dilani , Ng Shu‐Kay , Thomas Michael , Marks Darryn , Lewis Jeremy , Hides Julie , Bisset Leanne 
Published: May 2023

AbstractBackgroundMusculoskeletal shoulder pain is a common problem and its symptoms often become persistent. The experience of pain is multidimensional, and therefore, a range of patient characteristics may influence treatment response. An altered sensory processing has been associated with persistent musculoskeletal pain states and may contribute to outcomes in patients with musculoskeletal shoulder pain. The presence and potential impact of altered sensory processing in this patient cohort is not currently known. The aim of this prospective longitudinal cohort study is to investigate if baseline sensory characteristics are associated with clinical outcomes in patients presenting to a tertiary hospital with persistent musculoskeletal shoulder pain. If found, a relationship between sensory characteristics and outcome may lead to the creation of more effective treatment strategies and improvements in risk adjustment and prognosis.MethodsThis is a single‐centre prospective cohort study with 6‐, 12‐ and 24‐month follow‐up. A total of 120 participants aged ≥18 years with persistent musculoskeletal shoulder pain (≥3 months) will be recruited from an Australian public tertiary hospital orthopaedic department. Baseline assessments, including quantitative sensory tests and a standardised physical examination, will be performed. In addition, information will be obtained from patient interviews, self‐report questionnaires and medical records. Follow‐up outcome measures will comprise information from the Shoulder Pain and Disability Index and a six‐point Global Rating of Change scale.AnalysisDescriptive statistics will be used to report baseline characteristics and outcome measures over time. Change in outcome measures at the primary endpoint of six months from baseline will be calculated using paired t‐tests. Associations between baseline characteristics and outcomes at a 6‐month follow‐up will be reported using multivariable linear and logistic regression models.DiscussionUnderstanding the relationship between sensory profile and the variable response to treatment in people with persistent musculoskeletal shoulder pain may enhance our understanding of the mechanisms contributing to the presentation. In addition, through better understanding of the contributing factors, the results of this study may contribute to the development of an individualised, patient‐centred approach to treatment for people with this highly prevalent and debilitating condition.
The conformational behavior and structure of monosubstituted 1,3,5‐trisilacyclohexanes—Part III: 1‐Methyl‐1,3,5‐trisilacyclohexane
Authors: Kuzmina Liubov E. , Shlykov Sergey A. , Arnason Ingvar , Jonsdottir Nanna R. 
Published: May 2023

Abstract1‐Methyl‐1,3,5‐trisilacyclohexane was synthesized and its structure and conformational properties have been determined by gas‐phase electron diffraction (GED) and quantum chemical (QC) calculations. The molecule may exist in two forms differing from each other by the substituent's position. QC results show that the equatorial conformer is predicted to be slightly more stable than the axial conformer; note that one method (M06‐2X) with basis set 6‐311G** shows an equal amount of Ax and Eq conformers: ratio (Ax/Eq) = (30–50):(70–50)% (depending on the method and basis set). From the GED data, the molar fractions of the conformers were found to be Ax:Eq = 54(10):46(10) at 280(5) K. A temperature‐dependent Raman experiment resulted in an Ax:Eq ratio of 58(4):42(4). Conformational properties are compared in series of analogous 1‐X‐1‐(hetero)cyclohexanes.
Effects of Particle Size, Charge, Shape, Animal Disease State, and Sex on the Biodistribution of Intravenously Administered Nanoparticles
Authors: Ledford Benjamin T. , Wyatt Thomas G. , Vang Johnny , Weiss Jenna , Tsihlis Nick D. , Kibbe Melina R. 
Published: May 2023

AbstractThe relationship between nanoparticle size, charge, shape, and in vivo biodistribution is of great importance for the rational design and selection of intravenously administered nanoparticles. A resource that aids in the selection and design of nanomaterials for this purpose would be a valuable tool. Previous literature reviews have examined narrow categories of nanomaterials or have not statistically analyzed a broad range of nanomaterial literature. Here, data regarding the biodistribution of intravenously administered synthetic and organic nanomaterials in animal models from literature available in PubMed is collected. This work outlines the effect of nanoparticle size, charge, shape, animal sex, and animal disease status on biodistribution of intravenously administered nanomaterials. Particle size and charge are found to significantly and independently influence biodistribution to several organs. Finally, animal sex and disease state are observed to function as effect modifiers for biodistribution.
Exercise effects on motor function, manual dexterity, and brain oscillatory activity in individuals with Parkinson's disease: Randomized controlled trial protocol
Authors: Menacho Maryela de Oliveira , Pacheco‐Barrios Kevin , Mendes Augusto J. , Sato Tatiana de Oliveira , Fregni Felipe , Gianlorenço Anna Carolyna Lepesteur 
Published: May 2023

AbstractBackgroundParkinson's disease (PD) is the second most common progressive neurodegenerative disorder. Exercise protocols are promising interventions to improve PD symptoms, however, the best modality and its neural correlates are still unknown.ObjectivesTo evaluate the effects of the aerobic, strength and task‐oriented upper‐limb exercises in motor function, manual dexterity, and brain oscillations of individuals with PD.MethodIn this clinical trial, 44 PD patients aged 40–80 years will be randomized in four groups: aerobic training (AT), strength training (ST), task‐oriented training (TOT), and waiting list group (CG). The AT group will perform 30 min of a cycle ergometer on 50%–70% of the reserve heart rate. The ST group will use equipment for upper limb muscles and will perform two series of 8–12 repetitions for each exercise, and intensity between 50% and 70% of one maximum repetition will be used. The TOT group will perform a program consisting of three activities to enhance reaching, grasping, and manipulation. All the groups will perform three sessions per week for 8 weeks. We will use the UPDRS Motor function section, Nine‐Hole Peg Test, and quantitative electroencephalography to measure motor function, manual dexterity, and brain oscillations, respectively. ANOVA and regression models will be used to compare outcomes within and between groups.
Factors and strategies influencing implementation of an intravenous iron intervention for antenatal anaemia: A mixed‐methods systematic review
Authors: Verbunt Ebony , Akter Shahinoor , Manda‐Taylor Lucinda , Sarker Bidhan , Ataide Ricardo , Davidson Eliza , Pasricha Sant‐Rayn , Prang Khic‐Houy 
Published: May 2023

AbstractIntroductionAnaemia during pregnancy is a significant global health problem, disproportionately affecting women in low‐ and middle‐income countries (LMICs). Oral iron is the standard of care; however, challenges exist regarding adherence and coverage. Increasingly, evidence demonstrates the superiority of intravenous (IV) iron over oral iron. Although clinical experience on IV iron for antenatal anaemia is growing, there remains little understanding regarding implementation. Our mixed‐method systematic review aims to identify barriers and facilitators to implementing an IV iron intervention for pregnant women with anaemia and implementation strategies.MethodsFive bibliographic databases and grey literature were searched for studies. Barriers and facilitators were identified and mapped to the Consolidated Framework for Implementation Research (CFIR) and then matched to Expert Recommendations for Implementing Change (ERIC) strategies using the CFIR‐ERIC matching tool.ResultsThe search identified six studies. Most studies captured the perspective of healthcare providers, with some studies capturing the perspective of pregnant women. Barriers and facilitators were mapped to the following CFIR constructs: (1) intervention characteristics—cost, complexity, evidence strength and quality, and relative advantage; (2) outer setting—patient needs and resources; (3) inner setting—culture, available resources and access to knowledge and information; (4) characteristics of individuals—knowledge and beliefs about the intervention; (5) process—champions. Matching ERIC strategies included identifying and preparing champions, conducting educational meetings and assessing for readiness and identifying barriers and facilitators.ConclusionOnce tailored to each context, our findings can be used to improve the adoption, implementation, and sustainability of an IV iron programme for pregnant women with anaemia.
Autonomous detection and loading of ore piles with load–haul–dump machines in Room & Pillar mines
Authors: Cardenas Daniel , Loncomilla Patricio , Inostroza Felipe , Parra‐Tsunekawa Isao , Ruiz‐del‐Solar Javier 
Published: May 2023

AbstractAutomation of machines in underground mines is a topic with increasing interest, both for research and industrial applications. Autonomous load–haul–dump (LHD) machines need to load material successfully before dumping it into a crusher or an ore pass. The autonomous loading method must be robust to enable reliable operation of the LHD during long periods of time. In this work, a method to perform autonomous loading in Room & Pillar mines is presented. It is based on detecting all ore piles in real‐time, and then computing attack poses in each pile. Then, a positioning process is performed to get the machine in front of the selected ore pile, and an excavation algorithm is executed for loading until the bucket is filled. The proposed method is able to detect multiple ore piles, with different slopes and sizes, and to consider different possible trajectories for attacking and loading the most feasible pile. The method was tested in the Werra Potash Mine, under real operational conditions. The results show that the method can load about 80% of the material that an experienced operator can load. Also, the success rate of the autonomous loading process is very high, being able to load enough material in all trials, and performing successfully the full procedure in 88% of the cases. Thus, the proposed autonomous loading method is a suitable alternative to be used in Room & Pillar mines.
High‐Dispersive Pd Nanoparticles on Hierarchical N‐Doped Carbon Nanocages to Boost Electrochemical CO2 Reduction to Formate at Low Potential
Authors: Zhang Junru , Chen Yiqun , Xu Fengfei , Zhang Yan , Tian Jingyi , Guo Yue , Chen Guanghai , Wang Xizhang , Yang Lijun , Wu Qiang , Hu Zheng 
Published: May 2023

AbstractElectrochemical CO2 reduction reaction (CO2RR) to value‐added chemicals/fuels is an effective strategy to achieve the carbon neutral. Palladium is the only metal to selectively produce formate via CO2RR at near‐zero potentials. To reduce cost and improve activity, the high‐dispersive Pd nanoparticles on hierarchical N‐doped carbon nanocages (Pd/hNCNCs) are constructed by regulating pH in microwave‐assisted ethylene glycol reduction. The optimal catalyst exhibits high formate Faradaic efficiency of >95% within −0.05–0.30 V and delivers an ultrahigh formate partial current density of 10.3 mA cm−2 at the low potential of −0.25 V. The high performance of Pd/hNCNCs is attributed to the small size of uniform Pd nanoparticles, the optimized intermediates adsorption/desorption on modified Pd by N‐doped support, and the promoted mass/charge transfer kinetics arising from the hierarchical structure of hNCNCs. This study sheds light on the rational design of high‐efficient electrocatalysts for advanced energy conversion.
Triggering High Capacity and Superior Reversibility of Manganese Oxides Cathode via Magnesium Modulation for Zn//MnO2 Batteries
Authors: Xia Jiajia , Zhou Yurong , Zhang Jian , Lu Tianyu , Gong Wenbin , Zhang Dengsong , Wang Xiaona , Di Jiangtao 
Published: May 2023

AbstractAqueous zinc‐ion batteries (ZIBs) have attracted extensive attention in recent years because of its high volumetric energy density, the abundance of zinc resources, and safety. However, ZIBs still suffer from poor reversibility and sluggish kinetics derived from the unstable cathodic structure and the strong electrostatic interactions between bivalent Zn2+ and cathodes. Herein, magnesium doping into layered manganese dioxide (Mg–MnO2) via a simple hydrothermal method as cathode materials for ZIBs is proposed. The interconnected nanoflakes of Mg–MnO2 possess a larger specific surface area compared to pristine δ‐MnO2, providing more electroactive sites and boosting the capacity of batteries. The ion diffusion coefficients of Mg–MnO2 can be enhanced due to the improved electrical conductivity by doped cations and oxygen vacancies in MnO2 lattices. The assembled Zn//Mg–MnO2 battery delivers a high specific capacity of 370 mAh g−1 at a current density of 0.6 A g−1. Furthermore, the reaction mechanism confirms that Zn2+ insertion occurred after a few cycles of activation reactions. Most important, the reversible redox reaction between Zn2+ and MnOOH is found after several charge–discharge processes, promoting capacity and stability. It believes that this systematic research enlightens the design of high‐performance of ZIBs and facilitates the practical application of Zn//MnO2 batteries.
Genetic control of grain amino acid composition in a UK soft wheat mapping population
Authors: Oddy Joseph , Chhetry Monika , Awal Rajani , Addy John , Wilkinson Mark , Smith Dan , King Robert , Hall Chris , Testa Rebecca , Murray Eve , Raffan Sarah , Curtis Tanya Y. , Wingen Luzie , Griffiths Simon , Berry Simon , Elmore J. Stephen , Cryer Nicholas , Moreira de Almeida Isabel , Halford Nigel G. 
Published: May 2023

AbstractWheat (Triticum aestivum L.) is a major source of nutrients for populations across the globe, but the amino acid composition of wheat grain does not provide optimal nutrition. The nutritional value of wheat grain is limited by low concentrations of lysine (the most limiting essential amino acid) and high concentrations of free asparagine (precursor to the processing contaminant acrylamide). There are currently few available solutions for asparagine reduction and lysine biofortification through breeding. In this study, we investigated the genetic architecture controlling grain free amino acid composition and its relationship to other traits in a Robigus × Claire doubled haploid population. Multivariate analysis of amino acids and other traits showed that the two groups are largely independent of one another, with the largest effect on amino acids being from the environment. Linkage analysis of the population allowed identification of quantitative trait loci (QTL) controlling free amino acids and other traits, and this was compared against genomic prediction methods. Following identification of a QTL controlling free lysine content, wheat pangenome resources facilitated analysis of candidate genes in this region of the genome. These findings can be used to select appropriate strategies for lysine biofortification and free asparagine reduction in wheat breeding programs.