bluuebunny/crossref_metadata_2025_split huggingface dataset:
Averaging for slow–fast piecewise deterministic Markov processes with an attractive boundary
Authors: Génadot Alexandre 
Published: May 2023

AbstractIn this paper we consider the problem of averaging for a class of piecewise deterministic Markov processes (PDMPs) whose dynamic is constrained by the presence of a boundary. On reaching the boundary, the process is forced to jump away from it. We assume that this boundary is attractive for the process in question in the sense that its averaged flow is not tangent to it. Our averaging result relies strongly on the existence of densities for the process, allowing us to study the average number of crossings of a smooth hypersurface by an unconstrained PDMP and to deduce from this study averaging results for constrained PDMPs.
Association of meal-specific protein intake and cardiometabolic risk factors: a cross-sectional study
Authors: Firouzi Mahsa , Jabbarzadeh Bahareh , Mirrafiei Amin , Sadeghi Sara , Djafarian Kurosh , Shab-Bidar Sakineh 
Published: May 2023

AbstractWe aimed to investigate the association of main meals’ specific protein intake with cardiometabolic risk factors, including general and abdominal obesity, serum lipid profile, and blood pressure (BP). This cross-sectional study was conducted on 850 subjects aged 20–59 years. Dietary intakes were assessed by completing three 24-h recalls, and the protein intake of each meal was extracted. Anthropometric measures, lipid profile, fasting blood sugar and BP were measured. Multivariate logistic regression controlling for age, physical activity, sex, marital status, smoking status, BMI and energy intake was applied to obtain OR and CI. The mean age was 42 years, and the mean BMI of the participants was 27·2. The mean protein intake for breakfast, lunch and dinner was 12·5, 22·2 and 18·7 g/d, respectively. After adjustment for confounders, higher protein intake was not associated with any of the cardiometabolic risk factors, including LDL-cholesterol, HDL-cholesterol, total cholesterol (TC), TAG, body weight, BP and fasting plasma glucose, in any of the three main meals consumed within a day. Adherence to a higher protein intake at each meal was not associated with cardiometabolic risk factors in Iranian adults. Further prospective studies are needed to justify our findings.
Quantifying the effect of shoulder size on operation duration: an analysis of stapes surgery outcomes
Authors: Lenkeit Christopher P , Fritz Christian G , Choi Jonathan S , Schutt Christopher A , Hong Robert S , Babu Seilesh C , Bojrab Dennis I 
Published: May 2023

AbstractObjectiveTo investigate the effect of body mass index on hearing outcomes, operative time and complication rates following stapes surgery.MethodThis is a five-year retrospective review of 402 charts from a single tertiary otology referral centre from 2015 to 2020.ResultsWhen the patient's shoulder was adjacent to the surgeon's dominant hand, the average operative time of 40 minutes increased to 70 minutes because of a significant positive association between higher body mass index and longer operative times (normal body mass index group (<25 kg/m2) r = 0.273, p = 0.032; overweight body mass index group (25–30 kg/m2) r = 0.265, p = 0.019). Operative times were not significantly longer upon comparison of low and high body mass index groups without stratification by laterality (54.9 ± 19.6 minutes vs 57.8 ± 19.2 minutes, p = 0.127).ConclusionThere is a clinically significant relationship between body mass index and operating times. This may be due to access limitations imposed by shoulder size.
Seven new distributional records of cryptobenthic reef fishes in Lakshadweep, India
Authors: Babu Sandra , Anto Alvin , Sreeram Miriam Paul , Sreenath Kannanchery Ramanathan 
Published: May 2023

Abstract
Investigations on the diversity of cryptobenthic reef fishes resulted in observation of seven new geographic records for Lakshadweep waters, India: halfbarred goby Amblygobius semicinctus, target shrimpgoby Cryptocentrus strigilliceps, thread shrimpgoby Ctenogobiops mitodes, eye-bar goby Gnatholepis anjerensis, Miki's dwarfgoby Eviota mikiae, Erythrops goby Bryaninops erythrops, and Enneapterygius sp. Ctenogobiops mitodes is a new record to Indian waters. The genera Cryptocentrus and Bryaninops are reported from Lakshadweep for the first time. The observations were conducted in the lagoon and reef slope of Kavaratti Island, one of the 12 atolls of the Lakshadweep archipelago, from January–March 2021. The cryptobenthic reef fishes were observed and recorded through underwater photography and videography.
A longitudinal study of childhood maltreatment, subcortical development, and subcortico-cortical structural maturational coupling from early to late adolescence
Authors: Rakesh Divyangana , Elzeiny Reham , Vijayakumar Nandita , Whittle Sarah 
Published: May 2023

AbstractBackgroundExamining neurobiological mechanisms that may transmit the effects of childhood maltreatment on mental health in youth is crucial for understanding vulnerability to psychopathology. This study investigated associations between childhood maltreatment, adolescent structural brain development, and mental health trajectories into young-adulthood.MethodsStructural magnetic resonance imaging data was acquired from 144 youth at three time points (age 12, 16, and 18 years). Childhood maltreatment was reported to occur prior to the first scan. Linear mixed models were utilized to examine the association between total childhood maltreatment, neglect, abuse and (i) amygdala and hippocampal volume development, and (ii) maturational coupling between amygdala/hippocampus volume and the thickness of prefrontal regions. We also examined whether brain development mediated the association between maltreatment and depressive and anxiety symptoms trajectories from age 12 to 28.ResultsTotal maltreatment, and neglect, were associated with positive maturational coupling between the amygdala and caudal anterior cingulate cortex (cACC), whereby at higher and lower levels of amygdala growth, maltreatment was associated with lower and higher PFC thinning, respectively. Neglect was also associated with maturational coupling of the hippocampus with prefrontal regions. While positive amygdala-cACC maturational coupling was associated with greater increases in anxiety symptoms, it did not significantly mediate the association between maltreatment and anxiety symptom trajectories.ConclusionWe found maltreatment to be associated with altered patterns of coupling between subcortical and prefrontal regions during adolescence, suggesting that maltreatment is associated with the development of socio-emotional neural circuitry. The implications of these findings for mental health require further investigation.
Cultural contributions to adults' self-rated mental health problems and strengths: 7 culture clusters, 28 societies, 16 906 adults
Authors: Copeland William E. , Ivanova Masha Y. , Achenbach Thomas M. , Turner Lori V. , Tong Guangyu , Ahmeti-Pronaj Adelina , Au Alma , Bellina Monica , Caldas J. Carlos , Chen Yi-Chuen , Csemy Ladislav , da Rocha Marina M. , Dobrean Anca , Ezpeleta Lourdes , Funabiki Yasuko , Harder Valerie S. , Lecannelier Felipe , Leiner de la Cabada Marie , Leung Patrick , Liu Jianghong , Mahr Safia , Malykh Sergey , Markovic Jasminka , Ndetei David M. , Oh Kyung Ja , Petot Jean-Michel , Riad Geylan , Sakarya Direnc , Samaniego Virginia C. , Sebre Sandra , Shahini Mimoza , Silvares Edwiges , Simulioniene Roma , Sokoli Elvisa , Talcott Joel B. , Vazquez Natalia , Wolanczyk Tomasz , Zasepa Ewa 
Published: May 2023

AbstractBackgroundIt is unknown how much variation in adult mental health problems is associated with differences between societal/cultural groups, over and above differences between individuals.MethodsTo test these relative contributions, a consortium of indigenous researchers collected Adult Self-Report (ASR) ratings from 16 906 18- to 59-year-olds in 28 societies that represented seven culture clusters identified in the Global Leadership and Organizational Behavioral Effectiveness study (e.g. Confucian, Anglo). The ASR is scored on 17 problem scales, plus a personal strengths scale. Hierarchical linear modeling estimated variance accounted for by individual differences (including measurement error), society, and culture cluster. Multi-level analyses of covariance tested age and gender effects.ResultsAcross the 17 problem scales, the variance accounted for by individual differences ranged from 80.3% for DSM-oriented anxiety problems to 95.2% for DSM-oriented avoidant personality (mean = 90.7%); by society: 3.2% for DSM-oriented somatic problems to 8.0% for DSM-oriented anxiety problems (mean = 6.3%); and by culture cluster: 0.0% for DSM-oriented avoidant personality to 11.6% for DSM-oriented anxiety problems (mean = 3.0%). For strengths, individual differences accounted for 80.8% of variance, societal differences 10.5%, and cultural differences 8.7%. Age and gender had very small effects.ConclusionsOverall, adults' self-ratings of mental health problems and strengths were associated much more with individual differences than societal/cultural differences, although this varied across scales. These findings support cross-cultural use of standardized measures to assess mental health problems, but urge caution in assessment of personal strengths.
Association of current hepatitis B virus infection with mortality in adults with sepsis
Authors: Gao Chang , Ni Jingjing , Gao Ye , Xie Dan , Yang Lijuan , Yang Bining , Lu Xiaoting , Guo Qiang 
Published: May 2023

Abstract
This study aimed to determine the impact of current hepatitis B virus (HBV) infection on patients hospitalised with sepsis. This was a retrospective cohort study. Patients from three medical centres in Suzhou from 10 January 2016 to 23 July 2022 participated in this study. Demographic characteristics and clinical characteristics were collected. A total of 945 adult patients with sepsis were included. The median age was 66.0 years, 68.6% were male, 13.1% presented with current HBV infection, and 34.9% of all patients died. In the multivariable-adjusted Cox model, patients with current HBV infection had significantly higher mortality than those without (hazard ratio (HR) 1.50, 95% confidence interval (CI) 1.11–2.02). A subgroup analysis showed that being infected with HBV significantly increased in-hospital mortality in patients younger than 65 years old (HR 1.74, 95% CI 1.16–2.63), whereas no significant impact was observed in patients ≥65 years. The propensity score-matched case–control analysis showed that the rate of septic shock (91.4% vs. 62.1%, P < 0.001) and in-hospital mortality (48.3% vs. 35.3%, P = 0.045) were much higher in the propensity score-matched HBV infection group compared with the control group. In conclusion, current HBV infection was associated with mortality in adults with sepsis.
Tracking Crystal‐Melt Segregation and Accumulation in the Intermediate Magma Reservoir
Authors: Ma Jian‐Feng , Wang Xiao‐Lei , Yang Alexandra Yang , Zhao Tai‐Ping 
Published: May 2023

AbstractThe genesis of intermediate intrusions is highly controversial, and one of the hot topics is whether they represent frozen melts or cumulates in the evolution of magmatic systems. Distinguishing accumulation from crystallization melt differentiated along the liquid line of descent is the key issue. The Paleoproterozoic intermediate intrusions in southern North China Craton provide an excellent case to decipher this issue. Multiple lines of evidence, including mineral textures, geochemistry as well as alphaMELTS modeling, indicate disequilibrium between whole‐rock and minerals, with melt extraction occurring at temperatures of 760°–820°C and with 10–40 wt.% of trapped melts. Effective water storage, revealed by amphibole and clinopyroxene hygrometers, plays a crucial role in promoting crystal‐melt segregation in pluton‐sized reservoirs in the upper crust. This study demonstrates that the accumulation in intermediate magmas can be identified even without evident complementary initial and extracted melts and provides deep insights into the genesis of intermediate continental crust.
Bottom‐Up Evaluation of the Methane Budget in Asia and Its Subregions
Authors: Ito Akihiko , Patra Prabir K. , Umezawa Taku 
Published: May 2023

AbstractA comprehensive methane (CH4) budget, including spatial and temporal patterns of sources and sinks, is pivotal for effective climatic mitigation and prediction. This study used a bottom‐up approach to evaluate the CH4 budget of Asia during 1970–2021. Natural sources and sinks were evaluated using a process‐based biogeochemical model and with ground and satellite observations. Anthropogenic sources were evaluated using emission inventories produced by socioeconomic studies. During the 1970s and 2010s, anthropogenic emissions accounted for 78% and 84% of the emitted total CH4 budget of 140.2 and 207.6 Tg CH4 yr−1, respectively. Anthropogenic sources were responsible for a 49% increase in total emissions. During 2001–2021, Central, East, South, Southeast, and West Asia accounted for 3.3%, 35.1%, 25.6%, 23.1%, and 13.0%, respectively, of Asian emissions. Sectoral compositions and temporal variations differed among subregions. Emissions from paddy field soils in Asia were smaller in 2021 (33.6 Tg CH4 yr−1) than in 1970 (39.2 Tg CH4 yr−1) because of changes in agricultural production. Among natural sources, wetlands accounted for 63% of total emissions in East Asia, but geological emissions predominated in Central and West Asia. Interannual variability of the net CH4 budget was mainly due to wetland and biomass burning emissions, whereas decadal variability was due to anthropogenic sectors. δ13C‐CH4 and isoflux analysis of sector‐specific fluxes and isotopic ratios indicated the effects of the regional budget on atmospheric trends. Bottom‐up evaluations of regional budgets can provide information critical to the Global Stocktake of the Paris Agreement, the Global Methane Pledge, and other related actions.
Equatorial Ionization Anomaly Discontinuity Observed by GOLD, COSMIC‐2, and Ground‐Based GPS Receivers' Network
Authors: Cai Xuguang , Wang Wenbin , Eastes Richard W. , Qian Liying , Pedatella Nicholas.M. , Aa Ercha , Zhang Shunrong , Coster Anthea , Daniell Robert E. , McClintock William E. 
Published: May 2023

AbstractWe report a new ionosphere phenomenon: Equatorial ionization anomaly (EIA) discontinuity (EIAD), based on OI 135.6 nm radiance observations from the Global Observations of Limb and Disk (GOLD), ground‐based total electron content maps and in‐situ ion density data from Constellation Observing System for Meteorology, Ionosphere, and Climate‐2. The EIAD occurs when the OI radiance of the EIA crest has a local minimum, at a fixed UT, with the radiance in the local longitude region being weaker than that on the east and west sides. In the GOLD field‐of‐view, EIAD follows the seasonal variations of EIA. EIAD appears more often over the Atlantic Ocean and Africa than over South America. It occurs more in the southern crest during the December solstice, and more in the northern crest during both equinoxes. EIAD can occur under both quiet and disturbed times.
Genetic, environmental, and behavioral correlates of lifetime suicide attempt: Analysis of additive and interactive effects in two cohorts of US Army soldiers
Authors: Campbell-Sills Laura , Sun Xiaoying , Papini Santiago , Choi Karmel W. , He Feng , Kessler Ronald C. , Ursano Robert J. , Jain Sonia , Stein Murray B. 
Published: May 2023

AbstractRecently developed measures of genetic liability to suicide attempt may convey unique information regarding an individual’s risk of suicidal behavior. We calculated a polygenic risk score for suicide attempt (SA-PRS) for soldiers of European ancestry who participated in the Army STARRS New Soldier Study (NSS; n = 6573) or Pre/Post Deployment Study (PPDS; n = 4900). Multivariable logistic regression models were fit within each sample to estimate the association of SA-PRS with lifetime suicide attempt (LSA), and to examine whether SA-PRS displayed additive or interactive effects with environmental and behavioral risk/protective factors (lifetime trauma burden, childhood maltreatment, negative urgency impulsivity, social network size, perceived mattering, and dispositional optimism). Age, sex, and within-ancestry variation were included as covariates. Observed prevalence of LSA was 6.3% and 4.2% in the NSS and PPDS samples, respectively. In the NSS model, SA-PRS and environmental/behavioral factors displayed strictly additive effects on odds of LSA. Results indicated an estimated 21% increase in odds of LSA per 1 SD increase in SA-PRS [adjusted odds ratio (AOR; 95% CI) = 1.21 (1.09–1.35)]. In PPDS, the effect of SA-PRS varied by reports of optimism [AOR = 0.85 (0.74–0.98) for SA-PRS x optimism effect]. Individuals reporting low and average optimism had 37% and 16% increased odds of LSA per 1 SD increase in SA-PRS, respectively, whereas SA-PRS was not associated with LSA in those reporting high optimism. Overall, results suggested the SA-PRS had predictive value over and above several environmental and behavioral risk factors for LSA. Moreover, elevated SA-PRS may be more concerning in the presence of environmental and behavioral risk factors (e.g., high trauma burden; low optimism). Given the relatively small effect magnitudes, the cost and incremental benefits of utilizing SA-PRS for risk targeting must also be considered in future work.
Cardiac toxicities in multiple myeloma: an updated and a deeper look into the effect of different medications and novel therapies
Authors: El-Cheikh Jean , Moukalled Nour , Malard Florent , Bazarbachi Ali , Mohty Mohamad 
Published: May 2023

AbstractWith the continuous improvement in survival of cancer patients, including those with multiple myeloma, related to the novel treatment agents and therapeutic approaches, the probability for patients to develop cardiovascular disease has significantly increased, especially in elderly patients and those with additional risk factors. Multiple myeloma is indeed a disease of the elderly population and so these patients are, solely by age, at an increased risk of cardiovascular disease. Risk factors for these events can be patient-, disease- and/or therapy-related, and they have been shown to adversely impact survival. Cardiovascular events affect around 7.5% of patients with multiple myeloma and the risk for different toxicities has considerably varied across trials depending on patients’ characteristics and treatment utilized. High grade cardiac toxicity has been reported with immunomodulatory drugs (odds ratio [OR] around 2), proteasome inhibitors (OR 1.67–2.68 depending on the specific agent, and generally higher with carfilzomib), as well as other agents. Cardiac arrhythmias have also been reported with various therapies and drug interaction plays a significant role in that setting. Comprehensive cardiac evaluation before, during and after various anti-myeloma therapy is recommended and the incorporation of surveillance strategies allows early detection and management resulting in improved outcomes of these patients. Multidisciplinary interaction including hematologists and cardio-oncologists is critical for optimal patient care.
Enhanced Sestrin expression through Tanshinone 2A treatment improves PI3K-dependent inhibition of glioma growth
Authors: Schaf Judith , Shinhmar Sonia , Zeng Qingyu , Pardo Olivier E. , Beesley Philip , Syed Nelofer , Williams Robin S. B. 
Published: May 2023

AbstractGlioblastomas are a highly aggressive cancer type which respond poorly to current pharmaceutical treatments, thus novel therapeutic approaches need to be investigated. One such approach involves the use of the bioactive natural product Tanshinone IIA (T2A) derived from the Chinese herb Danshen, where mechanistic insight for this anti-cancer agent is needed to validate its use. Here, we employ a tractable model system, Dictyostelium discoideum, to provide this insight. T2A potently inhibits cellular proliferation of Dictyostelium, suggesting molecular targets in this model. We show that T2A rapidly reduces phosphoinositide 3 kinase (PI3K) and protein kinase B (PKB) activity, but surprisingly, the downstream complex mechanistic target of rapamycin complex 1 (mTORC1) is only inhibited following chronic treatment. Investigating regulators of mTORC1, including PKB, tuberous sclerosis complex (TSC), and AMP-activated protein kinase (AMPK), suggests these enzymes were not responsible for this effect, implicating an additional molecular mechanism of T2A. We identify this mechanism as the increased expression of sestrin, a negative regulator of mTORC1. We further show that combinatory treatment using a PI3K inhibitor and T2A gives rise to a synergistic inhibition of cell proliferation. We then translate our findings to human and mouse-derived glioblastoma cell lines, where both a PI3K inhibitor (Paxalisib) and T2A reduces glioblastoma proliferation in monolayer cultures and in spheroid expansion, with combinatory treatment significantly enhancing this effect. Thus, we propose a new approach for cancer treatment, including glioblastomas, through combinatory treatment with PI3K inhibitors and T2A.
Recombinant measles virus vaccine rMV-Hu191 exerts an oncolytic effect on esophageal squamous cell carcinoma via caspase-3/GSDME-mediated pyroptosis
Authors: Wu Ailing , Li Zhongyue , Wang Yilong , Chen Yi , Peng Jinkai , Zhu Mengying , Li Yueyue , Song Hai , Zhou Dongming , Zhang Chudi , Lv Yao , Zhao Zhengyan 
Published: May 2023

AbstractOncolytic viruses have recently been proven to be an effective and promising cancer therapeutic strategy, but there is rare data about oncolytic therapy in esophageal squamous cell carcinoma (ESCC), especially oncolytic measles virotherapy. Therefore, this study aimed to explore whether the recombinant measles virus vaccine strain rMV-Hu191 has an oncolytic effect against ESCC cells in vitro and in vivo and elucidate the underlying mechanisms. Our results showed that rMV-Hu191 could efficiently replicate in and kill ESCC cells through caspase-3/GSDME-mediated pyroptosis. Mechanistically, rMV-Hu191 triggers mitochondrial dysfunction to induce pyroptosis, which is mediated by BAK (BCL2 antagonist/killer 1) or BAX (BCL2 associated X). Further analysis revealed that rMV-Hu191 activates inflammatory signaling in ESCC cells, which may enhance the oncolytic efficiency. Moreover, intratumoral injection of rMV-Hu191 induced dramatic tumor regression in an ESCC xenograft model. Collectively, these findings imply that rMV-Hu191 exhibits an antitumor effect through BAK/BAX-dependent caspase-3/GSDME-mediated pyroptosis and provides a potentially promising new therapy for ESCC treatment.
Quantum process tomography with unsupervised learning and tensor networks
Authors: Torlai Giacomo , Wood Christopher J. , Acharya Atithi , Carleo Giuseppe , Carrasquilla Juan , Aolita Leandro 
Published: May 2023

AbstractThe impressive pace of advance of quantum technology calls for robust and scalable techniques for the characterization and validation of quantum hardware. Quantum process tomography, the reconstruction of an unknown quantum channel from measurement data, remains the quintessential primitive to completely characterize quantum devices. However, due to the exponential scaling of the required data and classical post-processing, its range of applicability is typically restricted to one- and two-qubit gates. Here, we present a technique for performing quantum process tomography that addresses these issues by combining a tensor network representation of the channel with a data-driven optimization inspired by unsupervised machine learning. We demonstrate our technique through synthetically generated data for ideal one- and two-dimensional random quantum circuits of up to 10 qubits, and a noisy 5-qubit circuit, reaching process fidelities above 0.99 using several orders of magnitude fewer (single-qubit) measurement shots than traditional tomographic techniques. Our results go far beyond state-of-the-art, providing a practical and timely tool for benchmarking quantum circuits in current and near-term quantum computers.