bluuebunny/crossref_metadata_2025_split huggingface dataset:
Blood Cell Disease Prediction with Machine Learning
Authors: Arshad Ateeqa , Fatima Arooj , Tahir Asad , Fatima Rida , Khalil Mudasira 
Published: January 2025

Our body has cells that provide oxygen to our cell nucleus, called red blood cells (RBC). The other cells that are fighting the disease in our body are called
the White Blood Cell (WBC), and some types of cells prevent bleeding with clotting processes. There are three main types of blood cells. If we have some disorder in these cells, then our body faces diseases like leukemia, lymphoma and myeloma. Blood cell diseases can be identified using blood cell image symptoms, causes, and present conditions. Blood smear images with surrounding images of red, platelet, and white cell breakdown play an important role in assessing and diagnosing a large range of illnesses, including infection, disease, and leukemia. Due to the segmentation or breakdown procedures, some image processing techniques are performed to improve picture detection quality. Blood cell segmentation remains a serious challenge. That’s why deep learning technology is used to get the blood cell images clearly with the application of cutting-edge technology for the white blood cells, platelets and red blood cells in blood smear images. The accuracy of blood cell smear images required for automatic illness identification has been demonstrated in previous research experiments. To tackle this blood cell disease issue and optimize the system's performance to detect the diseases present in blood cells, we can find through their images by proposing deep learning.
Di-Genic Inheritance in Genodermatoses: Insights from Two Consanguineous Cases in a Reference Lebanese Center within the Middle East and North Africa (MENA) Region
Authors: Kadhi Ayat , Hamie Lamiaa , Eid Edward , Nemer Georges , Kurban Mazen 
Published: January 2025

Introduction: Genodermatoses refer to a group of heterogenous rare genetic diseases with cutaneous expression. Several genodermatoses present with multisystem involvement that can range from mild to life-threatening conditions leading to increased morbidity and mortality. Objective: Given the paucity in the literature in the field of genodermatoses especially in the Middle East and North Africa (MENA) region and building up on the first established genodermatoses database based in Lebanon, this article aimed to decipher the genetic basis of 2 different types of skin-inherited diseases (androgenic alopecia and vitiligo). Methods: Herein, we propose the first di-genic model of inheritance which could be responsible for these 2 diseases, using Whole Exome Sequencing (WES) and GEO datasets. Results: We identified 2 gene variants FOXC1(p.His484Tyr) and SMARCD1 (p.Arg351Cys) responsible for androgenic alopecia and HPS1(p.Ser566Ter) and ITK (p.Pro521Leu) responsible for vitiligo. Further analysis using GEO datasets, confirmed the connectivity between the genes involved in each each disease. Conclusion: This study identified novel candidate disease genes and inheritance model that could explain the underlying phenotypes that could open the doors for a better-guided genomic approach for personalized treatment and early diagnosis.
REALIZED GENETIC GAIN AND SEED SOURCE X SITE INTERACTION ON STAND VOLUME PRODUCTIVITY OF ACACIA MANGIUM
Authors: Nirsatmanto Arif , Setyaji Teguh , Wahyuningtyas Reny Setyo 
Published: January 2025

Following the results of the comprehensive tree improvement programs for Acacia mangium, it is necessary to estimate the real amount of genetic improvement and to develop an improved seed deployment strategy. This study was aimed to verify realized genetic gain on stand volume productivity attained by the first-generation Seedling Seed Orchards (SSO) of A. mangium and to identify the magnitude of seed sources x site interaction as a basis for improved seed deployment. Seeds from five SSOs were tested together with seeds from seed stand in genetic gain trials which were established in South Kalimantan and Central Java. Realized gains were calculated from the percentage improvement of respective SSOs compared with seed stand at two and four years of age. Seed source x site interaction was investigated through analysis across the two sites. Results of the study showed that trees derived from the five SSOs produced better stand volume than those from seed stand. At four years of age, stand volume of the best SSO reached around 127 m3/ha in South Kalimantan and 84 m3/ha in Central Java. Realized genetic gain were around 66% at two years and 59% at four years in South Kalimantan, and around 136% at two years and 81% at four years in Central Java. Seed source x site interaction was not significantly different indicating superiority of improved seed were consistent across the two sites with the average realized gain ranging from 18% to 79% and 24% to 62% at two and four years, respectively.
THE EFFECT OF SILVICULTURAL TREATMENT ON STAND GROWTH OF LOGGED-OVER FOREST IN SOUTH PAPUA
Authors: Kuswandi Relawan 
Published: January 2025

Forest stand structure could be used as one of the variables in deciding the possibility to harvest forest product. On logged-over forests, data and information over stand structure could become the basis for decision making for harvesting. To measure and analyze yield on logged-over forest, each forest management unit (IUPHHK) is obligated to establish Permanent Sample Plots (PSPs) for monitoring the growth and yield of the managed stand. In some of the plots, maintenances and thinning treatments are applied while other plots are not treated. The results, after several years of observations, showed that there was a difference in stand structure (tree number) of each diameter class both in plots with treatment and without treatment. The rate of in-growth, up-growth and mortality varied between plots without and with treatment in each diameter class and length of time after harvesting. The average diameter increment of trees in the stands of the untreated plots was higher (0.60 cm yr-1) compared to the treated plots (0.55 cm yr-1).
KARO’S LOCAL WISDOM: THE USE OF WOODY PLANTS FOR TRADITIONAL DIABETIC MEDICINES
Authors: Situmorang Rospita Odorlina , Harianja Alfonsus H. , Silalahi Johansen 
Published: January 2025

This paper identifies the plant species used traditionally by Karo people in North Sumatra, to cure diabetes, analyses the cultural significance index of those plants for the Karo, and clarifies phytochemical contents of the plants. Data were collected using survey method from selected respondents (n=54) based on their knowledge and practices in utilising medicinal plants to cure diabetic disease. Index of Cultural Significance (ICS) of plants was determined using the method proposed by Turner. Results showed that twelve woody plant species have been used to cure diabetes: loning leave (Psychotria sp.), kacihe leave (Prunus accuminta Hook), umbrella tree leave (Maesopsis eminii Engl), mutamba leave (Guazuma ulmifolia Lamk), cepcepan leave (Villebrunea subescens Blume), pirdot/cepcepan lembu leave (Saurauia vulcani Korth), raru bark (Cotylelobium melanoxylo), breadfruit leave (Artocarpus altilis), salam leave (Syzygium polyanthum Wight), mahogany seed (Swietenia mahagoni (L.) Jacq), cinnamon bark (Cinnamomum burmani), and yellow bamboo rod (Bambusa vulgaris Schrad). Five of those plants: loning, umbrella tree, mutamba, raru and salam have the highest cultural significance level. These five plants are highly needed in large quatities by the Karo people, so their availability in the forest should be securely conserved and protected. The plants used contained alkaloids, flavonoids, phenolics and terpenoids which can help to lower blood sugar level.
UTILIZATION OF AREN (Arenga pinnata Merr.) SAWMILLING WASTE FOR EDIBLE MUSHROOM CULTIVATION MEDIA
Authors: Djarwanto Djarwanto , Suprapti Sihati 
Published: January 2025

Aren (Arenga pinnata Merr.) is a multipurpose tree that can be utilized for palm sugar, alcoholic drinks, beverages and construction wood. The use of aren sawdust has not been studied intensively. This study examines the utilization of aren sawdust as cultivation media for edible mushrooms. Aren sawdust was mixed with rice bran, CaCO3, gypsum, fertilizers and distilled water before sterilization in 30 minutes pressurized autoclave at 1210C and 1.5atm. The mixed media was inoculated with pure cultures containing four mushrooms species (Pleurotus flabellatus, P. ostreatus, P. sajor-caju and Lentinula edodes) and incubated for five weeks to allow mycelium growth producing fruit bodies. The fruit bodies were harvested everyday within four months and examined for its gained mushroom-weight and biological conversion efficiency/BE. The core part of aren trunk was cut into smaller pieces of 10 cm (width) by 5 cm (thickness), by 120 cm (length). Each core sample was bored from the surface inward, creating holes with a particular distance apart. Each hole was inoculated with pure cultures containing 6 mushroom species (four species above, P. cystidiosus and Auricularia polytricha). The inoculated samples were slanted on bamboo support, and placed in a bamboo hut. Harvesting was carried out everyday after the fruiting body became mature and examined for its gained mushroom weight. Results show that the use of sawdust supplemented with nutritious material is more likely to improve the mushroom yield than that of aren sawn-timber core.
La Economía de la provincia de Coclé y los créditos bancarios Años: 2018-2022
Authors: Tuñon G Edwin A 
Published: January 2025

La economía de la provincia de Coclé y los créditos bancarios, ha sido conocida en el imaginario colectivo por una economía del sector primario y la principal actividad la agroindustrial azucarera y la sal. El objetivo del artículo es caracterizar la forma de la economía coclesana en cuanto importancia del sector de la economía que más aporta y actividad económica que sobresale en el producto interno bruto provincial (pib) Hay un vacío de conocimiento de las características de la economía coclesana y su actividad principal en éste periodo. Métodos y Materiales: Diseño de las Ciencias Sociales. Tipo de cuantitativa. La fuente de información informes anuales del Ministerio de Economía y Finanzas, datos de la economía coclesana, cuentas nacionales de Instituto Nacional de Estadística y Censo, informes de redes sociales sobre economía coclesana. Se clasifica la información atendiendo los tres sectores de la economía: primario, secundario, terciario. Reconociendo el sector económico que más aporta y la actividad económica más importante por generación de riqueza, Discusión: La economía coclesana, ha sufrido transformaciones importantes, que hacen variar ésa realidad del siglo pasado con una economía del sector primario y actividad agroindustrial azucarera y de sal. La transformación se evidencia en la estadística de cuentas nacionales de la provincia de Coclé la cual en el periodo 2018-2022 del sector terciario y la principal actividad la construcción de viviendas y locales comerciales. Los créditos se centran en la actividad terciaria. Conclusiones La economía coclesana en el periodo 2018-2022 atendiendo la información de las cuentas nacionales provinciales se ha demostrado que es una economía con el sector terciario con créditos centrados en el sector y la principal actividad dentro del sector secundario lo es la construcción.
Teneurs des éléments en trace dans les hétérogénités du sud katanga, /RDCongo
Authors: MABIALA MULOMBA Philippe , BULAMBO Jean Pierre , NSOSANI MVIBUDULU Christian 
Published: January 2025

Résume

L’analyse par activation neutronique a été appliquée au dosage du cuivre, du cobalt et de l’uranium dans les hétérogénites provenant de l’exploitation artisanale dans certaines localités du Sud Katanga en République Démocratique du Congo.
Les teneurs trouvées montrent que ces hétérogenites sont intimement associés aux minerais de cuivre-cobaltet contiennent à des degrés divers de l’uranium pouvant susciter multiples écueils sur les plans environnemental et de la santé publique.

Mots clefs :	Hétérogénites, analyse par activation, exploitation artisanale, Uranium, Sud Katanga.
Spread of English usage
Authors: Namsraijav Munkhbayar 
Published: January 2025

Not only English has become a global language, but it is also essential to study the use of English in order to study its impact on social development and its role in society. Within this study we used qualitative studies such as sociological study, questionaries’ observation, have done analyses and summarized materials taken from magazines and other sources with a large media base and logical methods of comparison. In conclusion English is divided as general English and ESP for teaching method, for educational purposes it is divided as ENL-English for national language, ESL-English for second language, EIL- English as an international language. As English is being studied with special status more than 80 countries of the world it has become global language and it is estimated that by 2050, almost half of the world’s population, or 3 billion people will have mastered English to some degree. From here we can conclude that English status has been high in all field of the society and it has been showing high influence on the future development of the society.
Англи хэлний хэрэглээний тархалт
Хураангуй: Англи хэл дэлхийн хэл болсон төдийгүй англи хэл нийгмийн хөгжилд үзүүлэх нөлөө нийгмийн салбарт гүйцэтгэх үүргийг судлахын тулд англи хэлний хэрэглээг судлах нь зайлшгүй юм. Энэхүү судалгааны ажлын зорилго нь англи хэлний хэрэглээ буюу англи хэл нийгмийн салбарт ямар үүрэг гүйцэтгэж байгаа болон дэлхийн улс орнуудад хэрхэн хэрэглэгдэж байгааг судлахад оршино. Тус судалгааны ажилдаа чанарын судалгааны аргууд болох социологийн судалгаа, асуулга, ажиглалт, хэвлэл мэдээллийн бааз суурь бүхий томоохон сэтгүүлүүд болон бусад эх сурвалжаас авсан материалд анализ хийж нэгтгэн дүгнэх, жишин харьцуулах логикийн аргууд зэргийг ашиглав. Эцэст нь дүгнэн хэлэхэд англи хэлийг заах аргазүйн хувьд ерөнхий ба мэргэжлийн англи хэл, боловсролын салбарт хэрэглэгдэж буй зориулалтаар нь англи хэлийг үндэсний хэлний үүргээр хэрэглэж буй орон, англи хэлийн хоёрдогч хэлний зориулалтаар хэрэглэж буй орон, англи хэлийг олон улсын хэлний зориулалтаар хэрэглэж буй орон гэж ангилдаг байхад англи хэлийг дэлхийн улс орнуудад хэрэглэгдэж буй байдлаар нь англи хэл үндэсний хэл болсон орон, англи хэлийг өдөр тутмын албан ёсны хэлний үүргээр хэрэглэгдэг орнууд, англи хэлийг олон улсын хэлний зориулалтаар үзэж судалдаг орнууд гэх зэргээр ангилдаг байна. Ийнхүү англи хэлний хэрэглэгдэх үүрэг зориулалт болон хэрэглээ, нийгмийн салбарт гүйцэтгэх үүрэг цаашид өсөх хандлагатай байна.
Түлхүүр үгс: Англи хэл, төлөвлөлт, үүрэг, нийгмийн салбар, англи хэлний ирээдүй
Desain Arsitektur Enterprise Sistem Informasi Manajemen Arsip Di Kantor Kecamatan Gadingrejo
Authors: Khumaidi Ahmad , Andriyani Novita 
Published: January 2025

Di era reformasi saat ini ketergantungan manusia terhadap teknologi informasi semakin bertambah dengan ditandainya penggunaan akses internet yang semakin tersebar luas.sebagian kecil dari sistem pemerintahan, untuk dapat mengikuti perkembangan teknologi dan terus meningkatkan kemampuan kinerja dalam menggeloladata,sebagaimana pengarsipan surat mempunyai peran yang penting dalam satu sebuah instansi serta digunakan dalam mendukung proses kegiatan yang dilakukan oleh instansi.dengan adanya sistem pengarsipan ini bisa lebih mudah memproses dan mempercepat dalam mengelola data surat yang masuk maupun surat keluar serta dapat menyimpan surat secara digitalisasi dan memudahkan staff capil di kantor kecamatan Gadingrejo dalam pencarian surat masuk dan surat keluar berbasis website.dengan menggunakan metode	Enterprise Architektur Planning (EAP), dengan tujuan pengarsipan dokumen yang berbasis web ini dilakukan untuk membantumemudahkan dalam proses penyimpanan dokumen surat serta membantumemudahkan pihak instansi untuk pencarian surat masuk dan surat keluar sewaktu-waktu diperlukan dengan waktu yang singkat,oleh karena itu sistem ini sangat membantu staff instansi dikantor kecamatan Gadingrejo dalam melakukan pekerjaan sangat efektif dan efisien untuk dapat diterapkan.metode pengumpulan data dengan cara, observasi, studi kepustakaan, wawancara.berdasarkan pembahasan Enterprhise Architethure Planning Manajemen Arsip Pada Kantor Kecamatan Gadingrejo,Penelitian berharap agar sistem yang dibuat dapat membantu serta memudahkan dalam proses penyimpanan ,pencarian dan dokumen surat yang tidak mudah hilang atau tercecer.
METODE FORECASTING PENDAPATAN WARUNG MAKAN DENGAN MENGGUNAKAN METODE LEAST SQUARE
Authors: Mantouw Rosdiana Yudith , Behuku Gloria Ivana , Dewanti Ayu , Juliani Tri Neira , Birahy Fionety T , Pihahei Hobertina Geofany 
Published: January 2025

Kegiatan pengabdian kepada masyarakat (PKM) ini bertujuan untuk meramalkan pendapatan "Warung Makan Padang Ayah Poka" dengan menggunakan metode Least square. Pemilihan metode ini didasarkan pada kemampuannya dalam menghasilkan prediksi yang akurat melalui anlisis tren data historis. Data yang digunakan dalam penelitian ini mencangkup pendapatan bulanan warung makan selama tujuh bulan kedepan. Proses analisis dimulai dengan pengumpulan data pendapatan, diikuti dengan penerapan metode Least Square untuk mengidentifikasi pola tren dalam data tersebut. Selanjutnya , model matematika dibangun berdasarkan hasil analisis untuk memperkirakan pendapatan masa depan.
A Cross-sectional Study of Health-related Quality of Life among Adults with Type 2 Diabetes on Treatment with Herbal and Conventional Glucose-lowering Agents in Nairobi, Kenya
Authors: Karara Monicah Wanjiru , Okalebo Faith Apolot , Karimi Peter Ndirangu , Opanga Sylvia Adisa 
Published: January 2025

Background: Patients with type 2 diabetes often seek care from herbal clinics for glycemic control. The impact of herbal glucose-lowering therapies on quality of life in this patient population has not been studied adequately.
Aim: The study determined and compared health-related quality of life in patients with type 2 diabetes on treatment with herbal and conventional blood glucose-lowering agents in Nairobi, Kenya.
Methods: A cross-sectional study was conducted among 80 patients with type 2 diabetes attending a conventional clinic at Kenyatta National Hospital and 37 patients receiving care at New Life Herbal Clinic in Nairobi City County, Kenya. A general questionnaire was used to collect sociodemographic and clinical information from the study participants. The World Health Organization Quality of Life Brief Version questionnaire was used to assess the health-related quality of life in both groups. Descriptive data analysis was performed on all variables. The health-related quality of life scores were compared using the non-parametric Mann-Whitney test. Multiple linear regression analyses were used to identify the determinants of health-related quality of life. P-values equal to or less than 0.05 were considered to be statistically significant.
Results: Health-related quality of life scores in all the domains were significantly higher among the patients treated with conventional drugs compared to those treated at the herbal clinic (p<0.001). Patients in both groups had the highest scores in the social domain (median score: 66.67 [33.33-75] for herbal and 75 [75-97.92] for the conventional group). Among patients on herbal therapies, the lowest scores were on psychological aspect of HRQoL (45.83 [33.33-54.17]). Regarding overall quality of life, patients at Kenyatta National Hospital had significantly higher median scores (75 [75-100]) compared to those at the herbal clinic (50 [25-75], p< 0.001). Treatment with conventional glucose-lowering agents was associated with significantly higher HRQoL scores on all the domains (p< 0.001). Other factors associated with higher health-related quality of life scores were higher levels of education (p=0.010) and engagement in physical activity (p=0.001) for the physical domain; microvascular complications for the psychological domain (p=0.010) and male gender for the social domain (p=0.037).Additional factors associated with better environmental domain scores were male gender (p=0.033), older age (p=0.004), urban residence ( p=0.026) and alcohol intake (p=0.048).
Conclusions: Patients on treatment with conventional therapies for type 2 diabetes had higher health-related quality of life scores compared to those on herbal treatments. We identified modifiable factors that can be enhanced to improve the quality of life of individuals with type 2 diabetes in both conventional and herbal treatment settings.
Genetic Variants, Serum 25-Hydroxyvitamin D Levels, and Sarcopenia
Authors: Sha Tingting , Wang Yilun , Zhang Yuqing , Lane Nancy E. , Li Changjun , Wei Jie , Zeng Chao , Lei Guanghua 
Published: August 2023

ImportanceVitamin D deficiency is commonly associated with sarcopenia; however, the latest International Clinical Practice Guidelines for Sarcopenia do not recommend vitamin D supplementation for sarcopenia owing to a lack of an apparent therapeutic effect on the indices of sarcopenia among participants with replete vitamin D concentration (ie, 25-hydroxyvitamin D [25(OH)D] level &amp;gt;20 ng/mL) from randomized clinical trials. While there is consensus in all vitamin D guidelines that serum levels of 25(OH)D less than 10 ng/mL should be corrected, approximately 30% of the world population’s 25(OH)D levels range from 10 to 20 ng/mL, and it remains unclear whether such suboptimal levels can maintain optimal health, including sarcopenia risk.ObjectiveTo investigate the association of serum 25(OH)D level, especially suboptimal levels, with sarcopenia risk.Design, Setting, and ParticipantsThis genome-wide genetic association study was performed from August 2022 to February 2023 among the 295 489 unrelated European participants from the UK Biobank (2006-2010). Nonlinear and standard mendelian randomization analyses were used to examine the association of serum 25(OH)D concentration with sarcopenia risk.ExposuresA weighted genetic risk score using 35 unrelated single-nucleotide variants from the UK Biobank and weights from the SUNLIGHT Consortium was selected as an instrumental variable for serum 25(OH)D concentration.Main Outcomes and MeasuresThe primary outcome was sarcopenia, and the secondary outcomes consisted of grip strength, appendicular lean mass index, and gait speed.ResultsThe final genetic analyses included 295 489 participants (mean [SD] age, 56.3 [8.1] years; 139 216 female [52.9%]). There was an L-shaped association between genetically predicted serum 25(OH)D concentration and sarcopenia risk. The risk of sarcopenia decreased rapidly as 25(OH)D concentration increased until 20 ng/mL and then leveled off. The odds ratio of sarcopenia for serum 25(OH)D level of 10 vs 20 ng/mL was 1.74 (95% CI, 1.17-2.59). Similar patterns were also observed when the association between serum 25(OH)D concentration and risks of each of the sarcopenia indices were evaluated.Conclusions and RelevanceIn this mendelian randomization genetic association study of adults in the UK Biobank, the findings supported a nonlinear association between suboptimal 25(OH)D levels and sarcopenia risk. Randomized clinical trials among participants with suboptimal 25(OH)D levels are required to verify the potential causality.