bluuebunny/crossref_metadata_2025_split huggingface dataset:
Implementing Practice Facilitation in Research: How Facilitators Spend Their Time Guiding Practices to Improve Blood Pressure Control
Authors: Sutton Kent F. , Richman Erica L. , Rees Jennifer R. , Pugh-Nicholson Liza L. , Craft Macie M. , Peaden Shannon H. , Soroka Orysya , Mackey Monique , Cummings Doyle M. , Cherrington Andrea L. , Safford Monika M. , Halladay Jacqueline R. , Group Southeastern Collaboration to Improve Blood Pressure Writing 
Published: March 2023

Abstract
Background: Practice facilitators (PFs) oversee quality improvement (QI) initiatives aimed at enhancing patient outcomes and operational efficiencies. Little research has explored the amount of time PFs spend with practices on QI activities. This short report expands on previously published work which detailed a 12-month practice facilitation intervention focusing on improving hypertension control among people living in rural settings in the southeastern USA. This report analyzes data on the time PFs spent to guide 32 primary care practices in implementing QI activities to support enhanced outcomes in patients with high blood pressure.
Methods: As part of the parent study, the Southeastern Collaboration to Improve Blood Pressure Control trial, four PFs documented time spent: 1) driving to support practices; 2) working on-site with staff and clinicians; and 3) communicating remotely (phone, email, or video conference) with practice members. We analyzed the data using descriptive statistics to help understand time devoted to individual and aggregated tasks. Additionally, we explored correlations between practice characteristics and time spent with PFs.
Results: An average of 130 (SD 65) minutes was spent per visit driving to and from individual practices. The average time spent on-site per visit with practices was 87 (SD 37) minutes, while an average of 17 (SD 12) minutes was spent on individual remote communications. During the 12-month intervention, 1131 remote communications were conducted with practices. PFs spent most of their time with clinical staff members (n=886 instances) or with practice managers alone (n=670 instances) while relatively few on-site visits were conducted with primary care providers alone (n=15). In 19 practices, no communications were solely with providers. No significant correlations were found between time spent on PF activities and a practices’ percent of Medicaid and uninsured patients, staff-provider ratio, or FQHC status.
Conclusions: PFs working with practices serving rural patients with hypertension devote substantial time to driving, highlighting the importance of optimizing a balance between time spent on-site vs. communicating remotely. Most time spent was with clinical staff, not providers. These findings may be useful to researchers and business leaders who design, test, and implement efficient facilitation services.
Trial registration: NIH ClinicalTrials.gov. NCT number: NCT02866669. Registered 15 August 2016. https://clinicaltrials.gov/ct2/show/NCT02866669?term=NCT02866669&draw=2&rank=1.
NHLBI AWARD number: PCS-1UH3HL130691.
Changes in pancreatic and ileal flora and related relationships in experimental acute pancreatitis
Authors: Zhao Meng-Qi , Cui Meng-Yan , Jiang Qiao-Li , Wang Jing-Jing , Lu Ying-Ying 
Published: March 2023

Abstract
Background/Objectives: Gut microbiota dysbiosis is a complication of acute pancreatitis (AP). However, the composition of the pancreatic and ileal microbiota and their relationship during acute pancreatitis remain unknown.
Methods: AP was induced in mice using three modeling methods, Caerulein (CAE), Caerulein+lipopolysaccharide (CAE+LPS) and L-arginine (ARG). Pancreas and ileum were collected for histological study and bacterial 16S rRNA gene sequencing to investigate the changes in the pancreatic and ileal flora under different inductions and their relationships. Blood samples were tested for amylase, lipase, and inflammatory markers, and histological investigations were done to assess pancreatic and ileal pathological damage.
Results: All three modeling techniques led to inflammation and AP and ileal damage. Rarefaction and Shannon indices revealed that the pancreas and ileum of AP mice had higher levels of microbial diversity. Principal coordinate analysis (PCoA) and non-metric multidimensional scaling (NMDS) analysis showed microbial structural segregation in both the AP and control groups in the pancreas and ileum. In the three AP groups, there was microbial structural segregation between the ARG and the two CAE groups (CAE, CAE+LPS). Taxonomic analysis at the genus level showed a significant increase in the relative abundance of Muribaculaceae and a decrease in the relative abundance of Dietzia in the pancreas and ileum of AP mice. The same finding was found for linear discriminant analysis of effect size (LEfSe) at the operational taxonomic unit (OTU) level. In addition, the pancreas and ileum of both CAE groups were enriched with Roseburia, whereas the pancreas of the ARG group was enriched with Escherichia-Shigella. The abundance of Muribaculaceae and Dietzia in the pancreas is associated with that in the ileum, according to Spearman correlation analysis of the pancreatic and ileal microbiota.
Conclusions: These results showed that when AP was induced, caerulein and L-arginine differentially affected the pancreatic and ileal microbiota.
Efficacy and safety of theta burst versus repetitive transcranial magnetic stimulation for major depressive disorder: a meta- analysis of randomized controlled trials
Authors: Liu Chaomeng , Li Li , Zhu Kemeng , Liu Zhi , Xing Wenlong , Li Bing , Jin Wenqing , Lin Shuo , Tan Weihao , Pan Weigang , Ren Li , Zhang Qinge 
Published: March 2023

Abstract
Background: Theta burst stimulation (TBS) is more energy- and time-efficient than standard repetitive transcranial magnetic stimulation (rTMS). However, further studies are needed to analyze TBS therapy for its efficacy and safety compared to standard rTMS for major depressive disorder (MDD). The aim of this meta-analysis was to compare TBS therapy and standard rTMS treatment regarding their safety and therapeutic effect on individuals with MDD.
Methods: Six databases (Wanfang, the China National Knowledge Infrastructure, PubMed, Embase, Cochrane Library, and PsycINFO) were searched from inception till November 20, 2022. Two independent reviewers selected potentially relevant studies based on the inclusion criteria, extracted data, and evaluated the methodological quality of the eligible trials using the modified 10-item Physiotherapy Evidence Database scale per PRISMA guidelines.
Finally, ten comparable pairs of 9 randomized controlled trials were included for meta-analysis. Summary odds ratios (ORs) of the rates of response, remission, and adverse events were simultaneously calculated using quality-effects (QE) and random-effects (RE) models. Changes in depression scores associated with antidepressant effects were expressed using standardized mean differences (SMDs) simultaneously. This study was registered with PROSPERO (CRD42022376790).
Results: Nine of the 602 RCTs, covering 1196 cases (616 subjected to TBS protocols vs. 580 treated using standard rTMS), were enrolled. Differences in response rates between the above two treatment modalities were not significant (OR = 1.03, 95% CI: 0.90–1.18, P > 0.05, I2 = 4%, RE model; OR = 1.09, 95% CI: 0.90–1.32, P > 0.05, I2 = 4%, QE model). Differences in adverse event rates between TBS and standard rTMS groups were not statistically significant.
Conclusion: TBS has similar efficacy and safety as standard rTMS for treating MDD. In light of the short duration of daily stimulation sessions, this meta-analysis supports the continued development of TBS for treating depression.
HbA1c: an independent risk factor for dysthyroid optic neuropathy
Authors: Wang Xing , Ye Huijing , Chen Rongxin , Yang Shenglan , Zhang Te , Xiao Wei , Yang Huasheng 
Published: March 2023

AbstractBackgroundTo explore the frequencies of islet β-cell autoantibodies and insulin resistance (IR) in thyroid-associated ophthalmopathy (TAO) and identify specific diabetes mellitus (DM)indicators as early predictors for dysthyroid optic neuropathy (DON).MethodsNinety-eight TAO patients (57 DON and 41 non-DON patients) and 48 healthy control (HC) participants were recruited for this prospective cross-sectional study. Serum thyroxine, serum thyroid autoantibodies, serum humoral immune markers against islet β-cell, fasting plasma glucose (FPG), fasting serum insulin (FINS), fasting c-peptide (FCP), glycosylated hemoglobin A1 (HbA1c) were measured. Logistic regression analysis was used to evaluate the correlation of patients' age, body mass index (BMI), FPG, HbA1c, and related indexes of islet β-cell function to the occurrence of DON.ResultsTheDON group had higher FPG (P<0.001, 0.016) and HbA1c (P<0.0001, P<0.001) levels thanthe HC and non-DON groups. The homeostasis model assessment (HOMA)-IR level was highest in theDON group (HC 2.15±0.89, non-DON 2.41±1.24, DON 2.82±2.65), while the HOMA-β level was lowest (HC 101.8±44.75%, non-DON 102.9±54.61%, DON 88.29±52.75%), with no significant differences (P=1, P>0.05). On univariate analysis, age (P=0.006), BMI (P=0.022), history of steroid use (P=0.014), and FPG (P=0.013), HbA1c (P=0.001) levels were significantly associated with the presence/absence of DON. In addition, after adjusting for potential confounding factors, the HbA1c level was anindependent factor associated with DON (P=0.009, OR=4.012).ConclusionsHbA1c is an independent risk factor for DON. Given the inextricable link between thyroid dysfunction and DM, the use of HbA1c as a potential biomarker for DON warrants further investigation.
Development and assessment of novel machine learning models to predict the probability of postoperative nausea and vomiting for patient-controlled analgesia
Authors: Xie Min , Deng Yan , Wang Zuofeng , He Yanxia , Wu Xingwei , Zhang Meng , He Yao , Liang Yu , Li Tao 
Published: March 2023

Abstract
Postoperative nausea and vomiting (PONV) can lead to various postoperative complications. The risk assessment model of PONV is helpful in guiding treatment and reducing the incidence of PONV, whereas the published models of PONV do not have a high accuracy rate. This study aimed to collect data from patients in Sichuan Provincial People's Hospital to develop models for predicting PONV based on machine learning algorithms, and to evaluate the predictive performance of the models using the area under the receiver characteristic curve (AUC), accuracy, precision, recall rate, F1 value and area under the precision-recall curve (AUPRC). The AUC (0.947) of our best machine learning model was significantly higher than that of the past models. The best of these models was used for external validation on patients from Chengdu First People’s Hospital, and the AUC was 0.821. The contributions of variables were also interpreted using SHapley Additive ExPlanation (SHAP). A history of motion sickness and/or PONV, sex, weight, history of surgery, infusion volume, intraoperative urine volume, age, BMI, height, and PCA_3.0 were the top ten most important variables for the model. The machine learning models of PONV provided a good preoperative prediction of PONV for intravenous patient-controlled analgesia.
Artificial intelligence application in enterprise financial management big data calculation based on Virtual network mapping algorithm
Authors: Fu Feina 
Published: March 2023

Abstract
In recent years, in order to adapt to the development of the times, a new technology, namely network virtualization technology, has been produced. The research of network virtualization includes many aspects, but the most important thing is the constraint of node and link resources, as well as its topology requirements. Therefore, a new model has been developed in the corresponding era, namely the era of big data. The era of big data can bring us many benefits, and it will also bring us many disadvantages. The era of big data has provided a more comprehensive and accurate data analysis platform for corporate financial management, but it has also brought a huge impact to corporate traditional financial management. The current basic education financial risk prevention methods are relatively backward, traditional financial management mainly relies on manpower. Artificial intelligence is gradually developing and progressing, some artificial intelligence has some learning ability, knowledge reserve ability, and intelligent judgment and decision-making ability. This article uses a basic education group as the research object to analyze artificial intelligence technology in financial risk prevention and identification The application phenomenon in the process, and cited some cases for analysis.
Synergistic effect of local corticosteroid injection(LCI) with extracorporeal shock wave therapy(ESWT) in the treatment of patients with mild to moderate carpal tunnel syndrome(CTS): A Randomized Controlled Trial
Authors: gholipour morteza , bonakdar sona , gorji mona , minaei reza 
Published: March 2023

Abstract
Background: Applying extracorporeal shock wave therapy (ESWT) injection in carpal tunnel syndrome (CTS) management is gaining momentum. The objective is to actualize the topic of this study.
Methods: In this prospective randomized controlled trial, forty patients with mild to moderate CTS are divided into two sham-ESWT and ESWL groups subject to LCI(Local corticosteroid Injection). The first group received four sessions of sham-ESWT weekly, which involved sound but no energy; the second group received ESWT at equal intervals and were assessed for pain score (VAS score) and symptoms (GSS) baseline, 1st month, 3rd month, and 6th month.
Results: A considerable improvement is observed in both groups for pain at (P<0.05) and symptoms at (P<0.05) in the 3rd month. The second group revealed more significant symptom improvement at (P<0.05) in the 6th month.
Conclusion: The ESWT + LCI combined therapy course is the first line of treatment in patients with mild to moderate symptoms and leads to control and reduction of symptoms and the need for surgery, thus a primary concern in CTS treatment with an orthopedist.
Preconception education program for non-invasive prenatal testing focused on interest in genetics: a quasi-experimental study
Authors: Katada Chihiro , Ohashi Kazutomo , Okada Kimie , Sawai Hideaki 
Published: March 2023

Abstract
Background
Non-invasive prenatal testing (NIPT) is offered as a reproductive choice in many countries. However, pregnant women, particularly those who are primipara or lack knowledge of prenatal testing, experience difficulties understanding adequate information and making decisions on NIPT. This study developed a preconception education program about NIPT, focusing on interest in genetics, and aimed to clarify the effectiveness of the program to help women make decisions on future NIPT.
Methods
This was a one-group, quasi-experimental, pre-post-test study. The study population was female undergraduate students in Japan who participated in the education program. This program included two games and was based on the Attention, Relevance, Confidence, and Satisfaction (ARCS) model, which is an instructional design that stimulates learning interest and motivation. The data for 73 pre-pregnant women who completed all three questionnaires, before, immediately after, and three months after the intervention, were analyzed to clarify the time effects. Moreover, all variables were analyzed using logistic regression analysis to investigate factors related to decisional conflict.
Results
Interest in genetics, knowledge of genetics and prenatal testing, and indecisive attitudes toward NIPT significantly improved immediately after the intervention, and consequently, these changes and reduction of decisional conflict were maintained at three months. Moreover, low decisional conflict at follow-up was significantly associated with a high interest in genetics (adjusted odds ratio, 3.42).
Conclusions
These findings provide preliminary evidence that this preconception education program, which focused on facilitating interest in genetics, assists pre-pregnant women to reduce decisional conflict about future NIPT.
Trial Registration:
The trial was registered at the UMIN-CTR registry (16 Jan 2023), registration number UMIN000050047.
Effect of Limited Irrigation on Growth Parameters of Antirrhinum Majus
Authors: SEZEN IŞIK , YAĞANOĞLU SEVDA , KÜLEKÇİ ELİF AKPINAR , KARAHAN AYŞE 
Published: March 2023

Abstract
The aim of this research is to observe the change in the development parameters of the Antirhinum majus plant, which is the most widely used seasonal flower that causes excessive water consumption in green areas in cities, by subjecting it to limited irrigation. In this context; four different irrigation issues (completion of the amount of evaporating water (mm) obtained from the evaporation pot to 100% (control), 75%, 50% and 25% of the usable water holding capacity depending on the relationship of the pot volume) were created. To determine the effect of different water levels, 18 growth parameters were examined. As a result of the research; In Antirrhinum majus plant, on the other hand, in 17 of 18 parameters, it was observed that there was more improvement in 75% water application (25% water reduction) than 100% water application (0% water reduction). It is recommended to reduce water by 25% when using Antirrhinum majus plant in urban areas. In this case, significant water savings will be achieved in the urban landscape. Antirrhinum majus plants, which do not have any problems in their development despite the water shortage, are frequently used in urban landscapes.
Assessment of the causal relationship between depression and traits of sarcopenia: A bidirectional two-sample Mendelian randomization study
Authors: Tan Jianyu , Kong Yiting , Ai Ming , Hong Su , Zhang Yingxiao , Kuang Li 
Published: March 2023

Abstract
Background: Growing evidence reveals a significant association between depression and sarcopenia. However, the causal association between them remains elusive. We aimed to investigate the bidirectional relationship between depression and traits of sarcopenia.
Methods: We used genetic variants associated with depression (n=2,113,907), grip strength (n=256,523), appendicular lean mass (n=450,243), and walking pace (n=459,915) in bidirectional two-sample Mendelian randomization. The random-effects inverse-variance weighted method was adopted as the primary method.
Results: Mendelian randomization results revealed a causal relationship between depression and appendicular lean mass [β (95% confidence interval (CI)) = -0.051 (-0.086−(-0.016)), P=0.004], walking pace [OR (95% CI) = 0.973 (0.955−0.992), P=0.005]. Walking pace also revealed a causal relationship with depression [OR (95% CI) = 0.663 (0.507−0.864), P=0.002] in the reverse analysis. We observed no causal relationships between depression and grip strength. The leave-one-out sensitivity analysis verified our results.
Conclusions: This Mendelian randomization analysis verified the bidirectional relationship between depression and sarcopenia. Early diagnosis and prevention of either disease may enhance the management of another.
Validation of the Transplant Conditioning Intensity (TCI) Index for Allogeneic Hematopoietic Cell Transplantation
Authors: Spyridonidis Alexandros , Labopin Myriam , Gedde-Dahl Tobias , Ganser Arnold , Stelljes Matthias , Craddock Charles , Wagner-Drouet Eva , Versluis Jurjen , schroeder thomas , Blau Igor-Wolfgang , Wulf Gerald , Dreger Peter , Olesen Gitte , Sengeloev Henrik , Kroeger Nicolaus , Potter Victoria , Forcade Edouard , Passweg Jakob , de Latour Regis Peffault , Maertens Johan , Wilson Keith , Bourhis Jean Henri , Finke Jürgen , Brissot Eolia , Bazarbachi Ali , Giebel Sebastian , Savani Bipin N. , Nagler Arnon , Ciceri Fabio , Mohty Mohamad 
Published: March 2023

Abstract
The intensity of the conditioning regimen given before allogeneic hematopoietic cell transplantation (allo-HCT) can vary substantially. To confirm the ability of the recently developed transplant conditioning intensity (TCI) score to stratify the preparative regimens of allo-HCT, we used an independent and contemporary patient cohort of 4060 transplant recipients with acute myeloid leukemia meeting inclusion criteria from the discovery study (allo-HCT in first complete remission, matched donor), but who were allografted in a more recent period (2018–2021) and were one decade older (55–75 years, median 63.4 years), we assigned them to a TCI category (low n = 1934, 48%; intermediate n = 1948, 48%, high n = 178, 4%) according to the calculated TCI score ([1–2], [2.5–3.5], [4–6], respectively), and examined the validity of the TCI category in predicting early non-relapse mortality (NRM), 2-year NRM and relapse (REL). In the unadjusted comparison, the TCI index provided a highly significant risk stratification for d100 and d180 NRM, NRM and REL risk. In the multivariate analysis adjusted for significant variables, there was an independent strong association of TCI with early NRM, NRM and REL. In summary, we confirm in contemporary treated patients that TCI reflects the conditioning regimen related morbidity and anti-leukemic efficacy highly satisfactorily and across other established prognostic factors. TCI has all the features to be used as a well-defined, easy calculated and reproducible tool to define and measure intensity of the preparative regimen.
Controls of Root-System Overlap on Hillslope Stability
Authors: Gomi Takashi , Noviandi Rozaqqa , Sidle Roy , Iwasa Naoto , Ohtaka Norihiro 
Published: March 2023

Abstract
Forests greatly influence the global vulnerability towards shallow mass movement, particularly in hilly and mountainous terrain. Vegetation root systems can reinforce soil structure which thereby stabilizes hillslopes. Hence, root contributions to slope stabilization (i.e., root reinforcement) have normally been evaluated from individual trees or shrubs. In a hillslope with vegetation competing for resources, root reinforcement depends not only on values from individual vegetation species but also on the overlap of multiple root systems, which we define as “root system overlap”. Here, we evaluated the effect of root-system overlap on slope stabilization by using a laboratory-scale flume with various densities of peas (Pisum sativum L), i.e., 50 (V-005), 200 (V-02), 400 (V-04), and 1100 (V-11) stems/m2, representing trees at a 1:70 experimental scale. Time from the onset of applied rainfall to landslide initiation was the longest for V-11, whereas landslides in lower density vegetation (V-02 and V-005) had similar timing to those in non-vegetated conditions. The smallest landslide size occurred at V-04 with a similar timing of landslides in V-11. Estimated root reinforcement (∆C) became 0.004 N/m2 for V-005 to 4.03 N/m2 for V-11. Although root reinforcement in dense vegetation (V-11) was greatest, the formation of saturated soil areas was most rapid, possibly associated with preferential flow within the overlapping roots. The optimum condition for sufficient lateral root binding, duration of hydrological processes, and minimizing landslide area occurred in V-04 with 0.37 N/m2 of root reinforcement. Findings reveal that vegetation management by controlling tree density may effectively mitigate hillslope instability.