bluuebunny/crossref_metadata_2025_split huggingface dataset:
COMERCIALIZAÇÃO E CONSUMO DE PRODUTOS DA CAPRINOVINOCULTURA NA CIDADE DE BELÉM DO SÃO FRANCISCO – PE
Authors: Dias Weslla da Silva , Duarte Cabral Ana Maria , Alburquerque Héldon José Oliveira , Freire Nascimento Thiago Lucas , Oliveira Alburquerque Hildelberg , Vieira dos Santos Marcos Vinícios 
Published: March 2023

Objetivou-se conhecer o perfil dos pontos de comercialização e dos consumidores dos produtos e subprodutos da caprinovinocultura com uso de app em dispositivos móveis na cidade de Belém do São Francisco – PE. Para isto, foi realizada uma pesquisa de campo utilizando-se um aplicativo em aparelhos móveis contendo um questionário que serviu como base para as entrevistas aos comerciantes e 1,5% da população para caracterizar o perfil dos consumidores de produtos e derivados de caprinos e ovinos do município. Após a obtenção dos dados, eles foram quantificados e organizados em gráficos e tabelas para posteriores discussões. Foi observado que 50% da comercialização das carnes caprina e ovina é realizada em supermercados e que estes adquirem a carne dos produtores locais ou diretamente do matadouro municipal, com reflexo direto sobre os abates dos animais que são feitos de forma clandestina. A compra das carnes caprina e ovina corresponde a um preço, em média, de R$12,00 por Kg e a venda com o valor médio de R$14,00 por Kg. Ainda foi observado que dos 300 entrevistados, 285 pessoas são consumidores da carne caprina e/ou ovina 91 pessoas consumidores do leite caprino. Pode-se concluir que a cidade de Belém do São Francisco – PE apresenta um grande potencial para comercialização e consumo da carne caprina e ovina e leite caprino, mesmo que sejam comercializados no mercado informal.
Tinospora crispa Ethanolic Extract Downregulates Protein Kinase Genes Expression and Activity during Toxoplasma gondii Infection: A Prospective Drug Target for Lytic Cycle Inhibition
Authors: Abdullahi Sharif Alhassan , Nordin Norshariza , Unyah Ngah Zasmy , Basir Rusliza , Daneji Isa Muhammad , Nasiru Wana Mohammed , Majid Roslaini Abd 
Published: March 2023

Infection with Toxoplasma gondii remains widespread among humans and animals as water, soil and food continue to serve as the major carriers of the sporulated oocyst. The infection is poorly controlled due to lack of a potent vaccine against the parasite, and the current medication presents severe side effects on the host, less efficacy on the parasite and is accompanied by the potential development of resistance by the parasite. The aim of this study was to evaluate the in vitro activities of ethanolic extract of Tinospora crispa (EETC) on protein kinases involved in the lytic cycle of T. gondii infection in Vero cell line. The EETC was obtained through the maceration of dried stem powder. Vero cells infected with the RH strain of T. gondii were used to evaluate the inhibitory effect of EETC against T. gondii calcium dependent protein kinase (CDPK) genes and microneme proteins (MIC) that are essential for host cell invasion and intracellular replication of the tachyzoite. Gene expression profiling of CDPK genes was determined through quantitative real-time PCR (qPCR) after 24 h of treatment. The expression of microneme protein was determined through western blot technique. The RT-qPCR revealed downregulation of most protein kinase (PK) genes after treatment with EETC. The expression of CDPK1, PKG, CDPK3, CDPK6, CDPK7 genes that participate in the lytic cycle of T. gondii infection was downregulated. The expression of the TgMIC1 and TgMIC2 proteins were observed to have decreased in both 4 and 24 h post-infection treatment models. This study showed that EETC contains promising drug candidates effective against T. gondii that can target the protein kinase genes involved in the lytic cycle of the parasite to prevent disease progression.
HIGHLIGHTS

This study explored the possible mechanism of action of phytochemicals on Toxoplasma gondii parasite-host cell invasion and intracellular replication
The study evaluated the effects of ethanolic extract of Tinospora crispa Miers on protein kinase genes that are involved in host cell invasion
The target protein kinase genes were downregulated which prevents the secretion of microneme proteins
Inhibition of microneme secretion prevents host cell invasion and intracellular replication by Toxoplasma gondi

GRAPHICAL ABSTRACT
Juan Antonio García Solera (1924-1953-2019). Dibujar para construir
Authors: Oliva Meyer Justo , Calduch Cervera Joan 
Published: March 2023

Juan Antonio García Solera se tituló en la Escuela de Arquitectura de Madrid en 1953, habiendo estudiado, entre otros, junto a Javier Carvajal, Francisco Coello de Portugal, Eleuterio Población y Pedro Casariego con quienes compartía una misma actitud profesional característica de la arquitectura española de esas décadas centrales del siglo XX. El análisis de sus dibujos pone en evidencia el papel relevante que para él asumen en el proceso de creación de la arquitectura, como medio esencial para el control eficaz de su materialización constructiva. Un dibujo arquitectónico, trazado a mano alzada en la mesa de su estudio, que se revela como charnela insustituible entre la ideación de la obra y su construcción, y que ha sido una constante en toda su larga vida profesional hasta su fallecimiento en agosto de 2019 cuando se estaba redactando este artículo.
Pro Memoria
Authors: Tomaszewski Tadeusz 
Published: March 2023

Szanowni Państwo, Drodzy Czytelnicy!
W ostatnim okresie kryminalistyka poniosła wielką stratę. Odeszli od nas na zawsze wybitni przedstawiciele tej dyscypliny naukowej.
27 lipca 2020 roku zmarł prof. Jerzy Marian Konieczny. Urodził się 12 sierpnia 1950 r. Ukończył studia chemiczne. Był doktorem habilitowanym nauk prawnych, nauczycielem akademickim w Katedrze Kryminalistyki Uniwersytetu Śląskiego w Katowicach, Krakowskiej Akademii im. Andrzeja Frycza Modrzewskiego, Wyższej Szkole Zarządzania i Marketingu w Warszawie oraz na Wydziale Prawa i Administracji Uniwersytetu Opolskiego. W latach 1988–1989 był kierownikiem Zakładu Kryminalistyki Instytutu Ekspertyz Sądowych w Krakowie. W latach 1992–1993 pełnił funkcję szefa Urzędu Ochrony Państwa, a w latach 1995–1996 ministra spraw wewnętrznych. Autor wielu książek i publikacji naukowych z zakresu kryminalistyki, historii policji, prawa karnego, bezpieczeństwa biznesu i metodologii nauk prawnych.
Stories of Songs, Choral Activism and LGBTQ+ Rights in Europe
Authors: Hilder Thomas R. 
Published: March 2023

This paper attends to choral activism and LGBTQ+ rights in Europe. Drawing on models in a post-Stonewall US context, LGBTQ+ choirs have appeared since 1982 in urban centres throughout Europe, employing a range of repertoire, adopting innovative performance practices, and enacting public interventions. These choirs can affirm positive LGBTQ+ identities, create safer spaces, build local LGBTQ+ communities, offer sites of healing and sharing about different LGBTQ+ experiences, and increase visibility in the aid of LGBTQ+ rights (Balén 2017; De Quadros 2019; MacLachlan 2020). While LGBTQ+ rights may have become “a powerful symbol of Europe” (Ayoub and Paternotte 2014: 3) in the popular imagination and in the EU public discourse, in the last decade, new nationalist formations, increased violence toward LGBTQ+ people, and divisions within an apparent LGBTQ+ community have rendered queer Europeans at a critical juncture just as the project of Europe itself begins to crumble. As an activist within, and researcher of a European LGBTQ+ choral music scene, I will share with this paper stories of songs, choirs, festivals and choral networks inspired by Rita Felski’s notion of “hooked” (2020). Drawing on several years of ethnographic research in the UK, Italy and Poland, I ask: How have LGBTQ+ choirs shaped and been shaped by the struggle for LGBTQ+ rights locally, nationally and transnationally? What stories do these choirs tell us about the power of songs to bring about wider social transformation? How might LGBTQ+ choirs offer models of care, community and advocacy in a continent in crisis? Discussing an array of issues and cases – the Various Voices festival, the London Gay Men’s Chorus and the Cromatica network – and the potentials of applied methods, I invite us to listen to LGBTQ+ choral singing as a form of activism that continues to transform European 21st century politics and society.
The impact of digital transformation on the constitutional and legal foundations of the Russian Federation
Authors: Kostyukov A. N. , Cherepanova T. S. 
Published: March 2023

The subject. The impact of digital transformation on the foundations of the constitutional system, namely the possibility of its influence on their form, content and implementation system, has been studied in this article. The authors put forward a hypothesis about the formation of the principle of the digital state, which underlies the interaction of society and the state in the conditions of building a digital economy in Russia. Active implementation of this principle was observed during the COVID-19 pandemic. Also, the factors that can give an obvious and non-obvious impetus to the transformation of the constitutional identity of the foundations of the constitutional system are identified.The main functions of the constitutional principles are to preserve the stability of the foundations of the constitutional system and constitutional identity. We believe that modern legal science needs to comprehend the formation of new principles of interaction between society and public authorities, under the influence of digital technologies.
Genetic resources as an object of international law
Authors: Vylegzhanin A. N. , Sotskova P. V. 
Published: March 2023

The article examines whether the legal regime of genetic resources is outlined in the context of applicable rules relating to biological diversity. The purpose of the research is to confute the prospects for the formation of a universal legal regime for genetic resources, in the context of the draft UN Agreement on the Conservation and Sustainable Use of Marine Biological Diversity in Areas beyond National Jurisdiction, and the possibilities of using regional mechanisms in this domain.The methodology of the research includes the formal legal, comparative, historical, systemic and structural methods. The authors analyze and examine applicable international legal sources, including the 1992 Convention on Biological Diversity and its 2010 Nagoya Protocol. On the basis of the systemic and structural method the authors carry out the analysis of the sources of international law related to the conservation and sustainable use of genetic and other biological resources.The main results. The international community’s interest in genetic resources results from the growing need to take more informed environmental decisions. The relevant universal legal basis, created by the 1992 Convention on Biological Diversity, does not provide answers to some important questions, including the detailed legal definition of the term “genetic resources”, though the relevant definition contained in the 1992 Convention remains the only one that has been accepted by a large number of states. It is possible that states will be able to develop a more concrete legal rules relating to the genetic resources in the course of negotiating the UN Agreement on the Conservation and Sustainable Use of Marine Biological Diversity in Areas beyond National Jurisdiction. However, the development of such a universal international treaty might require a lot of effort in order to reconcile the divergent interests of states.Conclusions. Based on the analysis of applicable international law, the authors assert that the generally outlined legal basis for conservation of biodiversity, laid down by the 1992 Convention, demands further detailing in the modern context. The UN process on the conservation and sustainable use of marine biological diversity in areas beyond national jurisdiction is likely to take considerable efforts of participating actors before the appropriate legal mechanisms are agreed upon. So regional legal regimes might be an appropriate way to ensure the efficient management of genetic resources taking into account peculiarities of each individual region.
“The Golden Age of the Russian Old Believers and Sectarianism”: reform of the legal status of Old Believers and sectarians 1905-1906 through the prism of law enforcement
Authors: Tumanova A. S. , Safonov A. A. 
Published: March 2023

The article contains an analysis of the legal situation of sectarians and Old Believers of various consents after the publication of decrees on April 17, 1905 "On strengthening the principles of religious tolerance" and on October 17, 1906 "On the procedure for the formation and action of Old Believer and sectarian communities." The study is based on the materials of the Russian socio-political and Old Believer press, documents of private origin (diary entries of public and state figures), etc.The focus of the authors' attention is government decrees and circulars, as well as materials of lawsuits against Old Believers and sectarians. The authors recreate the law enforcement context of the implementation of the confessional reform of 1905–1906 and its impact on the legal life of representatives of Old Believer consents and sectarians, in particular, representatives of the so-called "Izuver" sects. Using the possibilities of formal-legal, comparative-legal and especially historical-biographical methods of historical-legal research, involving the analysis of current legislation by contemporaries, the authors come to the conclusion that the practice of applying new legislation contained numerous problem places. There were bureaucratic methods of reform, and dubious in some cases expert opinions of missionaries at trials, and a lack of understanding of the differences between Old Believers and sectarians, and other factors that make up the so-called "executor effect," which hindered the implementation of religious reform. The main drawback of law enforcement practice was seen by religious scholars in maintaining the principle of administrative guardianship of religious societies, which reflected the inconsistency of state policy in this matter.
Increasing civil participation in public control at the municipal level
Authors: Mikheeva T. N. , Mikheev D. S. 
Published: March 2023

The subject of the research is public control, which is considered to be a modern instrument of citizens' participation in the cases of local self-government. It significantly complements the basic mechanisms of direct democracy at the municipal level, providing the population with the opportunity to evaluate the activities of local authorities.The purpose of the study is to consider public control from the perspective of its implementation at the municipal level. The key task is to find and justify additional subjects close to this level, revealing new opportunities for a more active response of residents to the short-comings of the local authorities. The most important in this series is the definition of citizens’ role and the public structures they create in the implementation of public control. Another significant task is to develop recommendations for improving the legal regulation of public control at the municipal level.The methodology. The solution of the set tasks is supposed to be carried out using a number of cognition methods with the analysis as the leading one. It has become determinant in the study of scientific sources and the empirical base. The doctrinal method was used to study the opinions of legal scholars on the issue under discussion. Working with legislation regulating public control was based on a formal and logical method. To formulate the research conclusions the authors used general scientific methods of synthesis and analogy, as well as general-to-specific method.The main results. The analysis showed that the public chambers (councils) of municipalities created by local governments to exercise public control are to a certain extent dependent on these bodies. We focused on more independent segments of the local community that are not included in the law, but show examples of social activity. The resource of society increases many times if three new subjects at the municipal level are given legislative access to public control: citizens, local public associations, and organized groups of citizens – territorial public self-governments that successfully operate in the local territories of municipalities. Conclusions. The recommendations presented in the study are the basis for improving domestic legislation on public control and local self-government. Filling in the legislative gaps should have a positive impact on law enforcement practice. The practical nature of the received conclusions and proposals is that they open up new opportunities for the representatives of the local community: (a) to protect their rights and legitimate interests with the help of the tools of public control; (b) to promptly correct mistakes and miscalculations of local authorities. The authors are convinced that the development of democracy on the scale of such a huge state as the Russian Federation should start with a small entity — its entrance hall, street, neighborhood, settlement, and city.
TRANSFER PENGETAHUAN PENGENALAN MUSUH ALAMI DAN BIOPESTISIDA PADA KELOMPOK TANI UJUNG PANDANG, DESA BAPEANG, KECAMATAN MENTAWA BARU KOTAWARINGIN TIMUR
Authors: Melhanah  , Supriati Lilies , Mulyani Rahmawati Budi , Oemar Oesin 
Published: March 2023

Budidaya tanaman padi merupakan salah satu pekerjaan utama bagi masyarakat di Desa Bapeang, Kecamatan Mentawa Baru, Kabupaten Kotawaringin Timur. Petani dalam melakukan usaha pertaniannya sering berhadapan dengan serangan hama dan penyakit yang menjadi faktor pembatas dalam meningkatkan produksi tanaman. Tindakan pencegahan dan pengendalian hama maupun penyakit yang menyerang tanaman padi yang dilakukan petani adalah mengaplikasikan pestisida kimia. Tujuan program pengabdian masyarakat ini adalah transfer pengetahuan (transfer knowledge) memberikan pemahaman kepada petani tentang bahaya penggunaan pestisida kimia secara terus menerus dan memberikan solusinya berupa cara pengendalian lain yang lebih ramah lingkungan melalui pengelolaan serangga musuh alami dan mikrohabitatnya serta pengunaan biopestisida. Sasaran kegiatan pengabdian masyarakat adalah anggota Kelompok Tani Ujung Pandang, Desa Bapeang, Kecamatan Mentawa Baru. Metode kegiatan berupa sosialisasi dan penyuluhan secara langsung menggunakan Power Point Presentation tentang 1) Pengenalan musuh alami dan perannya pada ekosistem budidaya tanaman; 2) SosialisasiPengendalian OPT menggunakan Pestisida Nabati; 3) Pestisida Hayati Mikroba mengendalikan Penyakit Tanaman; dan 4) Diskusi terkait Konsep PHT dan Pengendalian Hama Penyakit Ramah Lingkungan. Hasil yang diperoleh adalah kesadaran petani akan bahaya pengaplikasian pestisida kimia secara terus menerus dan meningkatnya pemahaman petani tentang Musuh Alami Hama maupun Biopestisida yang dapat menjadi alternatif mengurangi penggunaan pestisida kimia, bahkan lebih aman dan ramah lingkungan. Hasil evaluasi menunjukkan bahwa proses kegiatan telah berjalan baik. Peserta yang hadir sangat antusias dalam sesi diskusi, materi yang disampaikan oleh tim merupakan pengetahuan baru yang belum pernah diperoleh sebelumnya. Hal ini menjadi motivasi bagi Tim pengabdian masyarakat melakukan koordinasi dengan Ketua Kelompok Tani untuk mendukung keberlanjutan program pada waktu yang akan datang, melalui praktek langsung di lahan budidaya
Educação, poder e resistência na era digital
Authors: Barbosa Manuel Gonçalves 
Published: March 2023

Este artigo tem o duplo objetivo de analisar a reconfiguração do poder na era digital e discutir, tendo em conta as suas perigosas consequências em termos individuais e sociais, o papel da educação na construção de atitudes defensivas relativamente a esse poder, hoje essencialmente protagonizado pelas grandes plataformas de serviços digitais. A opção metodológica consiste em aproveitar, para esses propósitos, não apenas um vasto acervo de obras recentes como algumas referências históricas importantes, nomeadamente foucaultianas. A estrutura organizativa do artigo inclui três secções: na primeira, aborda-se a reconfiguração do poder na era da transição digital; na segunda, analisa-se o modus operandi desse novo poder fazendo emergir, em toda a sua estranheza e complexidade, a categoria de governamentalidade tecnodigital; na terceira e última secção coloca-se a questão da resistência a essa insidiosa governamentalidade da era digital e o eventual contributo da educação nesse sentido, considerando as ações que se afiguram pedagogicamente pertinentes na instituição escolar.
Palavras-chave: educação; poder; resistência; plataformas digitais
Técnica de resina inyectada en paciente psicosocialmente afectada por presencia de diastema: Reporte de caso
Authors: Godoy Ávila José Antonio , Escobar de González Wendy , Fernández de Quezada Ruth , Aguirre Escobar Guillermo 
Published: March 2023

Introducción: Clásicamente los tratamientos utilizados para el cierre del diastema son de alto costo, altamente invasivos y de larga duración, en los últimos años se ha utilizado la técnica de resina inyectada como una alternativa de costo beneficio aceptable, rápida realización y significativamente menos invasiva a los tejidos dentarios, comparada con tratamientos convencionales. Objetivo: Presentar un reporte de caso del uso de la técnica de resina inyectada como una alternativa a los tratamientos convencionales para el cierre del diastema en una paciente con probable afectación psicosocial por su condición estética. Presentación del caso: Paciente femenina de 29 años de edad, que acude a la Facultad de Odontología de la Universidad de El Salvador, solicitando un tratamiento para el cierre de un diastema en el sector anterosuperior que le provoca incomodidad para sonreír, se le aplicó el índice PIDAQ para conocer las afectaciones psicosociales por el problema estético y se realizaron carilla de resina inyectada como tratamiento al diastema. Resultados: Se finalizó el tratamiento de carillas y en la evaluación clínica en 2 semanas se aplicó nuevamente índice PIDAQ encontrándose mejoría en la confianza de la paciente al sonreír y satisfacción con la forma de sus dientes Conclusión: El tratamiento para el cierre del diastema aumentó la confianza al sonreír, el uso de la técnica de resina inyectada es una opción que permite tener resultados rápidos, de bajo costo y menos invasivo a los tejidos dentarios en comparación con alternativas convencionales lo cual es relevante para la conservación del tejido sano.