bluuebunny/crossref_metadata_2025_split huggingface dataset:
Borehole-to-Surface Electrical Imaging Technology for Dynamic Monitoring of Underground Gas Storage and Case Study
Authors: Yang Qinrun , Tan Maojin , Chen Zhixin , Xu Bin , Zhang Fulai , Wang Bincheng , Yu Zhen , Zhao Haoyan 
Published: September 2023

Summary
To solve the issue of seasonal gas peak shaving, building underground gas storage is an effective solution. Geophysical monitoring technology is necessary for dynamic gas storage management. However, as these technologies are not highly accurate in the lateral direction, new technologies need to be developed. In recent years, borehole-to-surface electrical imaging (BSEI) technology has been widely used in reservoir and fracturing monitoring. In the dynamic monitoring of gas storage, high-power direct current is applied to the borehole through the steel casing, and the potential is measured on the surface. Then, resistivity inversion is performed to analyze the transverse distribution of the injected gas. To prove the feasibility of monitoring injected gas, a 3D forward case is simulated using the finite difference method (FDM). The model-structure-constrained inversion approach is verified. Based on the forward simulation results and the formation pressure period, the gas storage observation scheme is designed. The case study shows that the gas storage inversion results constrained by the upper formation have a high resolution and clearly show the transverse boundary of the target reservoir, which is consistent with the fault boundary determined by seismic prospecting. Therefore, 3D resistivity imaging can clearly show the distribution of gas reservoirs during injection and production. This study shows that BSEI is an effective technique for dynamic monitoring of gas storage and has good application prospects.
Complete Combinatorial Mutational Enumeration of a protein functional site enables sequence-landscape mapping and identifies highly-mutated variants that retain activity
Authors: Colom Mireia Solà , Vucinic Jelena , Adolf-Bryfogle Jared , Bowman James W. , Verel Sébastien , Moczygemba Isabelle , Schiex Thomas , Simoncini David , Bahl Christopher D. 
Published: September 2023

Abstract

Understanding how proteins evolve under selective pressure is a longstanding challenge. The immensity of the search space has limited efforts to systematically evaluate the impact of multiple simultaneous mutations, so mutations have typically been assessed individually. However, epistasis, or the way in which mutations interact, prevents accurate prediction of combinatorial mutations based on measurements of individual mutations. Here, we use artificial intelligence to define the entire functional sequence landscape of a protein binding site in silico, and we call this approach Complete Combinatorial Mutational Enumeration (CCME). By leveraging CCME, we are able to construct a comprehensive map of the evolutionary connectivity within this functional sequence landscape. As a proof of concept, we applied CCME to the ACE2 binding site of the SARS-CoV-2 spike protein receptor binding domain. We selected representative variants from across the functional sequence landscape for testing in the laboratory. We identified variants that retained functionality to bind ACE2 despite changing over 40% of evaluated residue positions, and the variants now escape binding and neutralization by monoclonal antibodies. This work represents a crucial initial stride towards achieving precise predictions of pathogen evolution, opening avenues for proactive mitigation.
Network pharmacological analysis of hydroxychloroquine intervention in the treatment of IgA Nephropathy
Authors: Zou Meng-xiao , Guo Kang-lin , Qian Duo , Cheng Yi-chun , Xu Gang , Ge Shu-wang 
Published: September 2023

Abstract

Background: IgA nephropathy (IgAN) is the most prevalent primary glomerulonephritis worldwide and has a high propensity to develop into End-stage renal disease (ESRD). Hydroxychloroquine has been proven to reduce proteinuria in patients with IgAN, while the precise mechanism remains unclear. Therefore, we use network pharmacology to investigate the mechanism.
Methods: We utilized PubChem and SwissADME databases to acquire the structure of hydroxychloroquine. Then, we utilized SwissTargetPrediction, PharmMapper, DrugBank, TargetNet, and BATMAN-TCM databases to get the targets. Furthermore, the target genes related to IgAN were gathered from the databases, including GeneCards, PHARMGKB, DrugBank, OMIM, and DisGeNET. And common targets were obtained by UniProt. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were undertaken to define the main molecular mechanisms and pathways. Moreover, we constructed protein-protein interaction (PPI) network by using the STRING tool and got the core targets by utilizing Cytoscape. Finally, the molecular docking between the core targets and hydroxychloroquine was performed.
Results: We acquired 167 common target genes by overlapping. The core targets were TNF, ALB, IL1B, JUN, FOS, SRC, and MMP9. The GO and KEGG results indicated the targets were related to the production of inflammatory cytokines and chemokines and were engaged in the Toll-like receptor (TLR) signaling pathway. Meanwhile, the molecular docking results demonstrated that the core targets all combined with hydroxychloroquine closely.
Conclusion: Our study indicated that hydroxychloroquine may treat IgAN through the TLR signaling pathway, and the restraint of TNF, TLR, ALB, and JUN may be crucial to the treatment.
The economic and technical feasibility analysis for solar power plant
Authors: Sandilya Rajeev Ranjan 
Published: September 2023

Abstract
Solar power plants connected to the grid have emerged as reliable sources of renewable energy to supplement conventional fossil fuel power plants connected to the grid. The capital investment for solar power projects has become economical in the present time due to the advancement in photovoltaic module technology. The investment in a solar power project is non-recourse in financial structure. The case study for project finance in the renewable energy domain is narrated with the help of the operation research methodology of mathematical models for financial statements. The economic viability of a project is analysed by financial metrics, i.e., internal rate of return (IRR), net present value (NPV), and debt service coverage ratio (DSCR). The mathematical model for financial statements provides forecasts of revenue and cash flow. The mathematical model provides a risk assessment for credit. The identification of technical requirements for a greenfield project is described for the assessment of the technical feasibility of the project. The decrease in capital and operating costs associated with the increase in efficiency of solar power plants, accompanied by the financial incentive scheme introduced by the government, provides attractive business opportunities for the renewable energy value chain.
Effective Strategies for Fecal Immunochemical Tests (FIT) Programs to Improve Colorectal Cancer Screening Uptake Among Populations with Limited Access to the Healthcare System: A Rapid Systematic Review
Authors: Belon Ana Paula , McKenzie Emily , Teare Gary , Nykiforuk Candace I.J. , Nieuwendyk Laura , Kim Minji (Olivia) , Lee Bernice , Adhikari Kamala 
Published: September 2023

Abstract
Background Colorectal cancer (CRC) is one of the leading causes of cancer death globally. CRC screening can reduce the incidence and mortality of CRC. However, socially disadvantaged groups may disproportionately benefit less from screening programs due to their limited access to healthcare. This poor access to healthcare services is further aggravated by intersecting, cumulative social factors associated with their sociocultural background and living conditions. This rapid review systematically reviewed and synthesized evidence on the effectiveness of Fecal Immunochemical Test (FIT) programs in increasing CRC screening in populations who do not have a regular healthcare provider or who have limited healthcare system access.Methods We used three databases: Ovid MEDLINE, Embase, and EBSCOhost CINAHL. We searched for systematic reviews, meta-analysis, and quantitative and mixed-methods studies focusing on effectiveness of FIT programs (request or receipt of FIT kit, completion rates of FIT screening, and participation rates in follow-up colonoscopy after FIT positive results). For evidence synthesis, deductive and inductive thematic analysis was conducted. The findings were also classified using the Cochrane Methods Equity PROGRESS-PLUS framework. The quality of the included studies was assessed.Results Findings from the 25 included primary studies were organized into three intervention design-focused themes. Delivery of culturally-tailored programs (e.g., use of language and interpretive services) were effective in increasing CRC screening. Regarding the method of delivery for FIT, specific strategies combined with mail-out programs (e.g., motivational screening letter) or in-person delivery (e.g., demonstration of FIT specimen collection procedure) enhanced the success of FIT programs. The follow-up reminder theme (e.g., spaced out and live reminders) were generally effective. Additionally, we found evidence of the social determinants of health affecting FIT uptake (e.g., place of residence, race/ethnicity/culture/language, gender and/or sex).Conclusions Findings from this rapid review suggest multicomponent interventions combined with tailored strategies addressing the diverse, unique needs and priorities of the population with no regular healthcare provider or limited access to the healthcare system may be more effective in increasing FIT screening. Decision-makers and practitioners should consider equity and social factors when developing resources and coordinating efforts in the delivery and implementation of FIT screening strategies.
SARS-CoV-2 Bottlenecks and Tissue-Specific Adaptation in the Central Nervous System
Authors: Richner Justin , Class Jacob , Simons Lacy , Lorenzo-Redondo Ramon , Cooper Laura , Dangi Tanushree , Penaloza-MacMaster Pablo , Ozer Egon , Rong Lijun , Hultquist Judd 
Published: September 2023

Abstract

Severe COVID-19 and post-acute sequelae of SARS-CoV-2 infection are associated with neurological complications that may be linked to direct infection of the central nervous system (CNS), but the selective pressures ruling neuroinvasion are poorly defined. Here, we assessed SARS-CoV-2 evolution in the lung versus CNS of infected mice. Higher levels of viral diversity were observed in the CNS than the lung after intranasal challenge with a high frequency of mutations in the Spike furin cleavage site (FCS). Deletion of the FCS significantly attenuated virulence after intranasal challenge, with lower viral titers and decreased morbidity compared to the wild-type virus. Intracranial inoculation of the FCS-deleted virus, however, was sufficient to restore virulence. After intracranial inoculation, both viruses established infection in the lung, but this required reversion of the FCS deletion. Cumulatively, these data suggest a critical role for the FCS in determining SARS-CoV-2 tropism and compartmentalization with possible implications for the treatment of neuroinvasive COVID-19.
Symptom burden and time from symptom onset to cancer diagnosis in patients with early-onset colorectal cancer: a multicenter retrospective analysis
Authors: Baronas Victoria , Arif Arif A. , Bhang Eric , Ladua Gale K. , Brown Carl J. , Donnellan Fergal , Gill Sharlene , Stuart Heather C. , Loree Jonathan M. 
Published: September 2023

Abstract

Background
The incidence of colorectal cancer (CRC) is decreasing in individuals > 50 years due to organised screening but has increased for younger individuals. We characterized symptoms and their timing before diagnosis in young individuals.
Methods
We identified all patients diagnosed with CRC between 1990–2017 in British Columbia, Canada. Individuals < 50 years (N = 2544, EoCRC) and a matched cohort > 50 (N = 2570, LoCRC) underwent chart review to identify CRC related symptoms at diagnosis and determine time from symptom onset to diagnosis.
Results
The most common symptoms at presentation for EoCRC and LoCRC are bloody stools (61.0% vs 40.2%, OR 2.3, 95%CI 2.1–2.6, p < 0.0001) and abdominal pain (51.8% vs 27.2%, OR 2.9, 95%CI 2.5–3.2, p < 0.0001). Across all stages of CRC, EoCRC presented with significantly more symptoms than LoCRC (Stage 1 mean ± SD: 1.3 ± 0.9 vs 0.7 ± 0.9, p = 0.0008; Stage 4: 3.3 ± 1.5 vs 2.3 ± 1.7, p < 0.0001). Greater symptom burden at diagnosis was associated with worse survival in both EoCRC (p < 0.0001) and LoCRC (p < 0.0001). The median time from symptom onset to cancer diagnosis was significantly longer for patients with EoCRC than LoCRC (143 days, 95%CI 134–154 vs 95 days, 95%CI 88–101, p < 0.0001). Despite this delay, survival for EoCRC presenting with a symptom duration > 6 months did not differ from those with shorter symptom duration (p = 0.58). When controlling for cancer stage, both age (HR 0.87, 95%CI 0.8-1.0, p = 0.008) and increasing symptom number were independently associated with worse survival in multivariate models.
Conclusions
Patients with EoCRC present with a greater number of symptoms of longer duration than LoCRC, however time from patient reported symptom onset was not associated with worse outcomes.
The causal role of insomnia in multiple chronic diseases: a systematic review and meta-analysis of Mendelian randomization studies
Authors: Wang Chi , Jiang Jing , Liu Chengyong , Wang Xiaoqiu , Wan Qingyun , Yuan Xiya , Liu Kai , Wu Wenzhong 
Published: September 2023

Abstract

Background: Insomnia is a significant public health issue interconnected with multiple chronic diseases, though the causal association remains elusive. Thus, the objective of this investigation is to undertake a meta-analysis of relevant Mendelian randomization research endeavors to validate the causal connection between insomnia and a spectrum of persistent afflictions.
Methods: The study searched databases for Mendelian randomization(MR) studies exploring the causal relationship between insomnia and chronic diseases, extracted data, and performed quality assessment. A meta-analysis was performed based on all MR studies that met the criteria and on the results of a de novo analysis based on data from the FinnGen consortium.
Results: Genetically predicted insomnia was associated with an increased risk of type 2 diabetes mellitus, 13 circulatory disease, 7 neuropsychological diseases, 3 digestive diseases, 10 pain diseases, asthma, and osteoarthritis as well as cancers of the respiratory system. In contrast, genetically predicted insomnia was not associated with 4 circulatory diseases, 8 neuropsychological diseases, 4 digestive diseases, tuberculosis, and 2 skeletal musculature diseases.
Conclusions: Insomnia has a causal association with numerous chronic diseases. Timely identification and management of insomnia are essential to prevent secondary illnesses, improve quality of life, and optimize healthcare resource utilization.
Utilization of Modern Menstrual Methods and related unmet needs among college going women in Coimbatore district: An analytical cross-sectional study
Authors: Durairaj Thavansree , Periyasamy Aparnavi , Narayanan Seetharaman , Mahantshetti Sushmitha , Dhandapani Srihari , Shanmugam Jeevithan , Moorthy Ramesh , Kumar Mohan 
Published: September 2023

Abstract

Objectives:The primary objectives were to determine the proportion of modern menstrual method (MMM) users among college going women in Coimbatore district, Tamil Nadu; and to estimate the unmet needs associated with use of MMMs in comparison with other menstrual hygiene methods (MHMs). We also assessed the factors that determine MMM use among college going women.Methods:This was an analytical cross-sectional study conducted among college going women in Coimbatore district, Tamil Nadu, India between October 2022 and January 2023 using a purpose predesigned, pretested, semi-structured proforma that included validated Menstrual Practice Needs Scale (MPNS-36).Results:Only 1.4% of the study participants used MMMs – menstrual cups (1.3%) and tampons (0.1%). Sanitary pads were the most common MHM of choice (96.3%); of which majority (98.6%) used disposable pads and more than half (50.4%) used non-biodegradable pads. Importantly, one in six (16.5%) were not aware of nature of sanitary pads (biodegradable or nonbiodegradable) used. The unmet needs associated with MMMs (menstrual cups and tampons) were significantly lower than that for other MHMs (including sanitary pads), in particular, the unmet material and home environment needs, unmet material reliability concerns, unmet reuse needs and unmet reuse insecurity. However, we found no significant difference between MMMs, sanitary pads and other MHMs in terms of unmet transport, college environment, change and disposal insecurity needs. The significant predictors of use of MMMs were age (more than 21 years of age), residence (urban), type of stay (off campus including home), socioeconomic status (upper), fathers’ and mothers’ education (high school and above), and presence of personal income. Discussions with friends (or peers) both before and after menarche regarding menstruation resulted in higher adoption of modern menstrual methods.Conclusion:MMMs provided comparative advantage with lesser unmet needs for material reliability and reuse insecurity concerns, particularly in home environment. However, none of the MHMs fulfilled the user expectations for transport and disposal insecurity concerns, particularly outdoors.
Control and treatment of bone cancer; a novel theoretical study
Authors: Abadi Ali Soltani Sharif , Rafeeyan Mansour , Abootalebi Vahid 
Published: September 2023

Abstract
The human body has symmetric bones. This paper uses control engineering concepts to design a suitable controller to synchronize two symmetric bones of the human body to control and treat bone cancer. A Nonsingular Terminal Sliding Mode Control (NTSMC) method will be employed to design the proposed control inputs. The control inputs can be the chemical drugs that can be used to treat bone cancer. The dynamical equations of bone cancer will be used to apply the designed control method and test it. For testing the designed controller, Simulink/MATLAB software will be used. The proposed controller is chattering-free, robust against uncertainties and external disturbances, and finite-time stable in the control engineering view. Bone cancer will be treated for almost one year using the proposed control method.
Preparation of amido-rich monolithic corn-bract via surface graft modification for efficient separation of acid red from wastewater
Authors: Zhang Zhijian , Luo Wenjun 
Published: September 2023

Abstract

A novel monolithic amidogen-rich biomass adsorbent was successfully prepared. Corn-bract (CB) was employed as adsorbent matrix, arginine (Arg) was selected as a bonding bridge between the hydroxyls on cellulose came from CB and modifier molecules to enrich reactive sites and improve reaction activity. Polyethylene imine (PEI) was then grafted to the surface of CB in a heterogeneous reaction. The resultant CB-g-PEI held a grafting ratio of 60.6 %. And the maximum adsorption for (acid red 18) AR18 was reached 506.7 mg/g. As a necessary content of adsorption behavior research. Models about isotherm adsorption, adsorption kinetics and adsorption thermodynamics were all inspected. According to the research conclusions obtained, The pseudo-second-order model provides the best explanation for the kinetics of adsorption. The adsorption isotherm of AR18 is in better agreement with the Langmuir isotherm model. The adsorption and desorption experiments were conducted over 6 times. The samples were characterized using FT-IR, SEM, EDS and etc. The study suggests that the CB-g-PEI is an available adsorbent.
Transcriptome responses to Ralstonia solanacearum infection in the tetraploid potato
Authors: Chen Zhuo , Zhu Xi , Zhang Yu , Shao Shunwei , Jin Hui 
Published: September 2023

Abstract
Potato (Solanum tuberosum L.) is a vital global food source, but its growth can be severely impacted by Ralstonia solanacearum (R. s) infection. Despite extensive research, the molecular mechanisms of potato resistance to this pathogen are not fully understood. Huashu No.12, a tetraploid potato genotype, has been identified as highly resistant to R. s. In this study, Huashu No.12 and Longshu No.7 were inoculated with R. s to evaluate disease resistance. Results showed that Huashu No.12 exhibited significantly higher resistance to R. s compared to Longshu No.7, with increased reactive oxygen species (ROS) and lignin content, as well as an abundance of corpus callosum and strong autofluorescence in the phloem sieve tube. Related enzymes, such as SOD, CAT, POD, PAL, and PPO, were also found to contribute to Huashu No.12's resistance to R. s disease. Transcriptome sequencing revealed 659 differentially expressed genes between resistant and susceptible materials, with the ERF family having the most differentially expressed genes. GO and KEGG analyses provided further insights into the genetic basis and molecular mechanisms underlying plant defense against R. sdisease. Overall, this study highlights the crucial role of related enzymes and differential gene expression in the resistance of Huashu No.12 to R. s, providing valuable insights into potato breeding for disease resistance.
Patients’ experience of the feasibility of a novel interdisciplinary nurse-led self-management intervention (INSELMA) – a qualitative evaluation
Authors: Blum Nadine Schäffer , Esbensen Bente Appel , Østergaard Mikkel , Bremander Ann , Hendricks Oliver , Lindgren Luise Holberg , Andersen Lena , Jensen Kim Vilbæk , Primdahl Jette 
Published: September 2023

Abstract
Background
Despite continuous improvements in anti-rheumatic pharmacological treatment, people with chronic inflammatory arthritis still report substantial disease impact. Based on the framework for complex interventions, we thus developed INSELMA, a novel nurse-coordinated multidisciplinary self-management intervention for patients with rheumatoid arthritis, psoriatic arthritis or axial spondyloarthritis. Based on individual biopsychosocial assessments, a rheumatology nurse facilitated goal setting and coordinated interdisciplinary support. The aim of this study was to explore the patients’ experience of participating in the six-months feasibility test of the INSELMA intervention.
Methods
Individual semi-structured interviews were conducted with 15 of the participants after their final follow-up. Thematic analysis was applied.
Results
The analysis derived four overall themes. 1) A new opportunity at the right time. The participants’ disease impacted all areas of daily life. Participation in INSELMA was experienced as an opportunity to improve symptoms and together reduce long-held challenges they had fought alone, until now. 2) The importance of person-centred goals. The participants found it meaningful to work with their individual goals, which encompassed physical, psychological, and social factors. Having time between consultations to work with goals at home was important. 3) Empathy, partnership and a little nudging from HPs are essential. The empathic nurses’ continuous support and coaching helped participants become aware of their own resources. The participants highlighted having access to support from a physiotherapist and occupational therapist with rheumatology experience as important. 4) I got more than I could have hoped for. Most of the participants experienced decreased symptom load and improvement in physical strength, mobility, sleep, and mood as well as increased energy, knowledge, and self-management ability. The participants expressed new hope for the future with an improved ability to manage their symptoms and work towards new goals.
Conclusion
The participants found the INSELMA intervention meaningful and feasible. They experienced decreased disease impact and increased activity levels, facilitated by empathy and self-management support from health professionals.