bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Role of the Transeptal Window in Endoscopic Endonasal Access to the Contralateral Orbit
Authors: Revuelta-Barbero Juan M. , Rodas Alejandra , Porto Edoardo , Vuncannon Jackson R. , Zohdy Youssef M. , Maldonado Justin , Solares C. Arturo , Henriquez Oswaldo , Pradilla Gustavo 
Published: September 2023

Abstract
Objective This study aimed to objectively compare maneuverability at the contralateral medial orbit when approached through the traditional endoscopic endonasal approach (EEA) and EEA with transeptal window (TW).
Study Design Anatomic dissections were performed bilaterally on three latex-injected cadaveric heads.  Approaches were performed sequentially; initially, an EEA was fashioned. Binostril access was achieved through a 2-cm posterior septectomy. The second stage pertained to the TW dissection. Area of exposure (AoE), surgical freedom (SF), and angles of attack (AoA) were measured along the contralateral medial orbital wall and compared for each approach. Additionally, the study presents an illustrative case describing the application of the EEA + TW for resection of an intraorbital schwannoma.
Results Compared with EEA, EEA + TW yielded a significantly greater AoE along the contralateral medial orbital wall (39.45 vs. 48.45 cm2, respectively; p = 0.002). SF was statistically different between the EEA and EEA + TW (1153.25 vs. 2256.33 cm2, respectively; p = 0.002). AoA in the horizontal plane were significantly broader with the EEA + TW (6.36 vs. 4.9 degrees by EEA; p = 0.015).A 50-year-old male with a right medial extraconal orbital tumor was successfully treated through an EEA using the transeptal corridor to access the medial orbital region. No long-term complications were encountered after 31 months of follow-up.
Conclusion EEA + TW is a minimally invasive technique that maximizes exposure and maneuverability within the medial orbital wall, allowing resection of lesions that extend anteriorly. EEA + TW limits disruption of the nasal septum and overcomes the obstacle that intranasal anatomy represents for instrumentation.
Left populism, commons and radical democracy: counter-hegemonic alliances in our times
Authors: Kioupkiolis Alexandros 
Published: September 2023

AbstractThis paper advances the thesis that democratic populism and the commons can and should complement each other in counter-hegemonic interventions promoting egalitarian and ecological democracy in our times. After elucidating its key terms, the article makes, first, a theoretical case for the combination of egalitarian, inclusionary populism and the commons by debunking arguments which highlight the conflicts between them and by explaining the political significance of their conjugation. Subsequently, discussion builds an empirical argument for the real possibility and the democratic promises of such a convergence by considering three ways in which populist politics and the commons merge and recompose each other in contemporary social movements, from the Spanish 15M and new municipalism to Occupy and other collective contestation in the Americas over the last two decades. These cases will illustrate how late social activism has effectively blended populist mobilization with the spirit of the commons, engendering a hybrid figure of ‘common populism’ that fosters grassroots processes of democratization.
Compact multi-channel radio frequency pulse-sequence generator with fast-switching capability for cold-atom interferometers
Authors: Jiang Min , Lu Si-Bin , Li Yang , Sun Chuan , Yao Zhan-Wei , Li Shao-Kang , Chen Hong-Hui , Chen Xiao-Li , Lu Ze-Xi , Mao Yin-Fei , Li Run-Bing , Wang Jin , Zhan Ming-Sheng 
Published: September 2023

Cold-atom interferometers have matured into a powerful tool for fundamental physics research, and they are currently moving from realizations in the laboratory to applications in the field. A radio frequency (RF) generator is an indispensable component of these devices for controlling lasers and manipulating atoms. In this work, we developed a compact RF generator for fast switching and sweeping the frequencies and amplitudes of atomic-interference pulse sequences. In this generator, multi-channel RF signals are generated using a field-programmable gate array (FPGA) to control eight direct digital synthesizers (DDSs). We further propose and demonstrate a method for pre-loading the parameters of all the RF pulse sequences to the DDS registers before their execution, which eliminates the need for data transfer between the FPGA and DDSs to change RF signals. This sharply decreases the frequency-switching time when the pulse sequences are running. Performance characterization showed that the generated RF signals achieve a 100 ns frequency-switching time and a 40 dB harmonic-rejection ratio. The generated RF pulse sequences were applied to a cold-atom-interferometer gyroscope, and the contrast of atomic interference fringes was found to reach 38%. This compact multi-channel generator with fast frequency/amplitude switching and/or sweeping capability will be beneficial for applications in field-portable atom interferometers.
Design principles for engineering wetlands to improve resilience of coupled built and natural water infrastructure
Authors: Shah Reepal , Tsai Yushiou , Stampoulis Dimitrios , Damavandi Hamidreza Ghasemi , Sabo John 
Published: September 2023

Abstract
Intensifying climate extremes and the ageing of built infrastructure have prompted the idea of replacing the ageing built infrastructure with natural infrastructure. In this paper, we discuss how a distributed portfolio of smaller wetlands performs compared to a flood control reservoir in terms of flood mitigation. Using a framework of a loosely coupled land surface model with a hydrodynamic model, in the Brazos basin (Texas), we find that (i) two smaller wetlands have more impact on flood mitigation than one double sized wetland, and (ii) creating multiple wetlands (prioritized based on storage) increases flood mitigation. Further, we find that a portfolio of wetlands equivalent to the size of the submergence area of the biggest flood control reservoir (Whitney) in the basin, can create additional flood control storage, equivalent to ∼10% of the total storage of Lake Whitney. Creating a portfolio of wetlands can increase the overall resiliency of the basin.
Translational biomaterials of four-dimensional bioprinting for tissue regeneration
Authors: Faber Leah , Yau Anne , Chen Yupeng 
Published: September 2023

Abstract
Bioprinting is an additive manufacturing technique that combines living cells, biomaterials, and biological molecules to develop biologically functional constructs. Three-dimensional (3D) bioprinting is commonly used as an in vitro modeling system and is a more accurate representation of in vivo conditions in comparison to two-dimensional cell culture. Although 3D bioprinting has been utilized in various tissue engineering and clinical applications, it only takes into consideration the initial state of the printed scaffold or object. Four-dimensional (4D) bioprinting has emerged in recent years to incorporate the additional dimension of time within the printed 3D scaffolds. During the 4D bioprinting process, an external stimulus is exposed to the printed construct, which ultimately changes its shape or functionality. By studying how the structures and the embedded cells respond to various stimuli, researchers can gain a deeper understanding of the functionality of native tissues. This review paper will focus on the biomaterial breakthroughs in the newly advancing field of 4D bioprinting and their applications in tissue engineering and regeneration. In addition, the use of smart biomaterials and 4D printing mechanisms for tissue engineering applications is discussed to demonstrate potential insights for novel 4D bioprinting applications. To address the current challenges with this technology, we will conclude with future perspectives involving the incorporation of biological scaffolds and self-assembling nanomaterials in bioprinted tissue constructs.
Excoriating Stalin, Criticizing Mao
Authors: Wagner Martin 
Published: September 2023

Abstract
Stalin and Mao both left pasts of terror and trauma their heirs had to address to embark on reforms that altered the quality of governance. In 1956 and 1978, Nikita Khrushchev and Deng Xiaoping confronted their Communist Parties with painful pasts and reevaluated the leaders’ respective legacies. Although facing similar challenges in dealing with the devastating ramifications of arbitrary rule and cults of personality, Soviet and Chinese strategies to approaching party history strongly differed. Diachronically comparing post-Stalinist and post-Maoist politics of memory reveals how communist regimes came to terms with the past. Analyzing synchronic and diachronic transfers between Moscow and Beijing demonstrates the lessons Deng Xiaoping drew from Soviet de-Stalinization and China’s perception of it in the late 1970s. Thus, Sino-Soviet reevaluations of the past were entangled, and not only because Deng Xiaoping—who had attended the Soviet Party Congress in 1956—shaped China’s interpretation of it and took the lead in revising Mao’s legacy in the 1970s.
Neighborhood Deprivation, Perceived Stress, and Pregnancy-Related Hypertension Phenotypes a Decade Following Pregnancy
Authors: Scott Jewel , Hauspurg Alisse , Muldoon Matthew F , Davis Esa M , Catov Janet M 
Published: September 2023

Abstract

BACKGROUND
Hypertensive disorders in pregnancy and other adverse pregnancy outcomes (APOs) increase the risk of developing chronic hypertension and cardiovascular disease. Perceptions of stress and neighborhood context also influence blood pressure (BP) fluctuations. We examined if APOs, higher perceived stress, and neighborhood deprivation were associated with hypertension phenotypes a decade after pregnancy in untreated individuals.

METHODS
Participants were 360 individuals who gave birth between 2008 and 2009 and participated in a research study 8–10 years following pregnancy. Standardized office and home BP readings were obtained, and we applied the AHA/ACC 2017 guidelines to identify sustained, white coat, and masked hypertension phenotypes. We measured personal stress with the perceived stress scale and neighborhood deprivation with the CDC Social Vulnerability Index.

RESULTS
Of the 38.3% (138/360) with any hypertension, 26.1% (36/138) reported a diagnosis of hypertension but were currently untreated. Sustained hypertension was the most common (17.8%), followed by masked and white coat hypertension, both 10.3%. Hypertensive disorders in pregnancy were associated with sustained (odds ratio [OR] 5.54 [95% confidence interval, CI 2.46, 12.46] and white coat phenotypes (OR 4.20 [1.66, 10.60], but not masked hypertension (OR 1.74 [0.62, 4.90]). Giving birth to a small for gestational age infant was also associated with sustained hypertension. In covariate adjusted models, perceived stress, but not neighborhood deprivation, was significantly associated with masked hypertension.

CONCLUSIONS
A decade after delivery, APOs were associated with sustained and white coat hypertension, but not masked hypertension. Exploration of the mechanisms underlying, and clinical implications of, these associations is warranted.
Attention-based generative adversarial networks improve prognostic outcome prediction of cancer from multimodal data
Authors: Shi Mingguang , Li Xuefeng , Li Mingna , Si Yichong 
Published: September 2023

Abstract
The prediction of prognostic outcome is critical for the development of efficient cancer therapeutics and potential personalized medicine. However, due to the heterogeneity and diversity of multimodal data of cancer, data integration and feature selection remain a challenge for prognostic outcome prediction. We proposed a deep learning method with generative adversarial network based on sequential channel-spatial attention modules (CSAM-GAN), a multimodal data integration and feature selection approach, for accomplishing prognostic stratification tasks in cancer. Sequential channel-spatial attention modules equipped with an encoder–decoder are applied for the input features of multimodal data to accurately refine selected features. A discriminator network was proposed to make the generator and discriminator learning in an adversarial way to accurately describe the complex heterogeneous information of multiple modal data. We conducted extensive experiments with various feature selection and classification methods and confirmed that the CSAM-GAN via the multilayer deep neural network (DNN) classifier outperformed these baseline methods on two different multimodal data sets with miRNA expression, mRNA expression and histopathological image data: lower-grade glioma and kidney renal clear cell carcinoma. The CSAM-GAN via the multilayer DNN classifier bridges the gap between heterogenous multimodal data and prognostic outcome prediction.
Bridging the gaps: management of lichen planus subtypes in a joint dermatology–oral surgery clinic
Authors: Pawlowski Johannes , Beczinski Janina , Stege Henner , Mann Caroline , Butsch Florian , Al-Nawas Bilal , Kaya Sebahat , Wittmann Miriam 
Published: September 2023

Abstract
Lichen planus (LP) presents with a range of clinical subtypes. It can affect the outer skin, involve the nails and present with alopecia and mucosal symptoms to varying degrees. LP of the outer skin mostly shows a self-limiting course; however, this is not the case for lichen planopilaris and the mucosa-affecting subtypes. The pathogenesis of LP is still incompletely understood. As a result, an effective, targeted therapy is currently lacking and different immunomodulatory approaches are being used in clinical practice. The management of patients with severe oral LP mucosae can be particularly challenging. Although the true risk remains controversial, oral LP is considered a risk factor for the development of squamous cell carcinoma and there is a need for regular screening. The quality of life in patients with LP is significantly impaired because of frequent clinical visits, pain, soreness, inability to eat certain foods, side effects to medication, frustrating therapy attempts and worry regarding cancer risk. We highlight here the advantages of an interdisciplinary dermatology and oral surgery clinic, which can address the domains of tooth status, nutrition, pain and malignant transformation and optimized patient management.
A-016 Clinical Performance Comparison Between the Vitros Immunodiagnostic Products NT-proBNP II and Roche Elecsys proBNP II Assays to Aid in the Diagnosis of Heart Failure
Authors: Ott-Vasconi A , Ajongwen P , Alvey S , Herman J 
Published: September 2023

Abstract

Background
The International Collaborative of NT-proBNP (ICON) study established NT-proBNP levels for the diagnosis and exclusion of acute heart failure for patients presenting to the emergency department (ED). Following the development of the Vitros Immunodiagnostic Products NT-proBNP II assay, a multi-center prospective study was conducted at 20 EDs across the United States. The study enrolled subjects presenting with dyspnea and clinical suspicion of heart failure (HF). Clinical performance of the Vitros Immunodiagnostic Products NT-proBNP II assay using the cutoffs established in the ICON study was compared to that of the Roche Elecsys proBNP II assay using samples from the multi-center study.

Methods
Clinical sensitivity, specificity, negative predictive value (NPV), and positive predictive value (PPV) were determined by comparing the assay result interpretation using the corresponding cutoffs against the adjudicated diagnosis of HF/non-HF. Clinical performances were then compared between the VITROS NT-proBNP II and the Roche Elecsys proBNP II assays. Analyses were performed using both the age-independent and age-dependent cutoffs within and across age groups.

Results
After applying the rule-in cutoffs from the ICON study to the Vitros NTproBNP II and the Roche Elecsys proBNP II assay results, the clinical performance of the Vitros NT-proBNP II assay was comparable to that of the Roche Elecsys proBNP II assay (see Table 1).

Conclusion
The use of the ICON cutoffs resulted in high assay specificity to rulein HF and excellent sensitivity to ruleout HF. The Vitros NT-proBNP II assay demonstrated comparable clinical performance to the Roche Elecsys proBNP II assay.
A-018 Biological Variation Estimates for N-terminal pro-B-type Natriuretic Peptide from Eight Healthy Turkish Women
Authors: Coşkun A , Abou-Diwan C , Rhea-McManus J , Serteser M , Unsal I , Locatelli M , Carobene A 
Published: September 2023

Abstract

Background
B-type natriuretic peptide (BNP) and its precursor N-terminal pro-B-type natriuretic peptide (NT-proBNP) are released primarily by the ventricles in the heart in response to volume or pressure overload. Measurements of NT-proBNP are used as an aid in the diagnosis and assessment of severity of congestive heart failure (CHF). Within- (CVI) and between-subject (CVG) biological variation (BV) estimates for NT-proBNP are limited. Here biological variability (BV) estimates from eight apparently healthy Turkish women for NT-proBNP are provided.

Methods
Serum samples were collected weekly from 24 healthy subjects (12 male, 12 female) for 10 consecutive weeks and stored at −80 °C prior to analysis. Study participant samples were analyzed in duplicate within a single run using the Atellica® IM NT-proBNP (PBNP) assay* on the Atellica IM Analyzer. Outlier detection, variance homogeneity analyses, and trend analysis were performed followed by CV-ANOVA to determine BV and analytical variation (CVA) estimates with 95% CI. The asymmetrical reference change values (RCV) using the lognormal approach, index of individuality (II), and analytical performance specification (APS), based on the CVA estimate derived in our study, were also calculated.

Results
PBNP results from 11 males and 3 females were lower than the limit of quantitation (LoQ) of the assay (&lt;35 pg/mL). The remaining male sample was not included in the analysis. One female sample was identified as an outlier between individuals and was excluded from the analysis. To fulfil criteria for variance homogeneity of the data from eight women, 7% of results were excluded. In total, 104 analytical results were included in the analysis. PBNP data for the female group was normally distributed, and no trends were identified by regression analysis. The BV estimates derived from females were CVI: 23.7%, (95% CI 19.0–30.4) and CVG: 8.22%, (95% CI 0.0–24.7). The CVA obtained from replicate test results was 11.2% (95% CI 9.4–13.9), which was lower than the desirable APS for imprecision. The II, calculated as the ratio of CVI/CVG, indicated a low individuality of PBNP (defined as II &gt; 1.6). Thus, use of a population-based reference interval for interpreting serial PBNP measurements is more appropriate than use of the RCV.

Conclusions
This study provides updated BV estimates for NT-proBNP derived from a protocol consistent with European Federation of Clinical Chemistry and Laboratory Medicine recommendations. The availability of BV estimates allows for refined APS and associated II and RCV, which are applicable when using PBNP as an aid in the diagnosis and assessment of severity of congestive heart failure.
*The products/features mentioned here are not commercially available in all countries. Their future availability cannot be guaranteed.
A-069 Atellica® Ci 1900 Sample Carryover Performance Evaluation
Authors: Pham T , Kolewe K , Ho M , Lewisch S , Snyder J 
Published: September 2023

Abstract

Background
The Atellica® CI 1900 Analyzer uses independent integration and random-access sampling to process chemistry (CH) and immunoassay (IM) tests. A single-use, disposable sample tip is used for IM assays, whereas a reusable dilution probe is used for CH assays. When a sample tube is first accessed by the CH dilution probe to process CH assays, then accessed by the IM disposable tip to process IM assays, there is the potential for sample carryover that could affect IM assay results. The purpose of this investigation was to evaluate sample-to-sample carryover performance on the Atellica® CI 1900 Analyzer.

Methods
Hepatitis B surface antigen (HBsAg) was selected as the test analyte, given the extreme HBsAg concentrations that can exist in clinical samples. High HBsAg pools ranging from 25 to 55 million Index values were prepared by spiking purified HBsAg into serum. Eleven low (L) samples containing 600 µL of HBsAg-negative control QC and 10 high (H) samples containing 300 µL of the high HBsAg serum pool were created. The samples were first processed with one replicate per sample with the Atellica® CH ALT assay on the Atellica® CI 1900 Analyzer so that the CH dilution probe would aspirate 50 µL of sample. Sample-to-sample carryover testing was performed in a defined high (H)- and low (L)-sample consecutive sequence: L1, L2, L3, H1, H2, L4, H3, H4, L5, L6, L7, L8, H5, H6, L9, H7, H8, L10, H9, H10, L11. All low (L) samples were next assayed for HBsAg using the Atellica® CI 1900 Analyzer. The sample carryover study was conducted on three Atellica® CI 1900 Analyzers. Carryover in parts per million (ppm) was determined by multiplying the difference of the “high-low” mean (L4, L5, L9, L10, L11) and “low-low” mean (L2, L3, L6, L7, L8) by 1 000 000 and dividing by the high HBsAg sample concentration.

Results
The measured sample carryover results were 0.00, 0.00, and 0.00 ppm. All three Atellica® CI 1900 Analyzers produced sample-to-sample carryover of &lt;0.1 ppm using HBsAg as the analyte.

Conclusions
The Atellica® CI 1900 Analyzer* demonstrated the capability to ensure sample-to-sample carryover of &lt;0.1 ppm into primary sample containers with a minimum of 600 µL sample volume.
*Not available for sale in the US. Product availability varies by country.