bluuebunny/crossref_metadata_2025_split huggingface dataset:
Short and medium-term effects of the COVID-19 lockdowns on child and parent accelerometer-measured physical activity and sedentary time: a natural experiment
Authors: Jago Russell , House Danielle , Salway Ruth , Walker Robert , Emm-Collison Lydia , Sansum Kate , Breheny Katie , Churchward Sarah , Williams Joanna G , Hollingworth William , de Vocht Frank 
Published: September 2023

Abstract
Background
The COVID-19 pandemic has resulted in marked impacts on children’s physical activity, with large reductions in moderate-to-vigorous physical activity (MVPA) reported during lockdowns. Previous evidence showed children’s activity levels were lower and sedentary time higher immediately post-COVID lockdown, while there was little change in parental physical activity. We need to know if these patterns persist.

Methods
Active-6 is a natural experiment using repeated cross-sectional data conducted in two waves. Accelerometer data were collected on 393 children aged 10–11 and their parents from 23 schools in Wave 1 (June 2021-December 2021), and 436 children and parents from 27 schools in Wave 2 (January 2022-July 2022). These were compared to a pre-COVID-19 comparator group (March 2017-May 2018) of 1,296 children and parents in the same schools. Mean minutes of accelerometer-measured MVPA and sedentary time were derived for week- and weekend-days and compared across waves via linear multilevel models. We also analysed the date of data collection as a time series, to explore temporal patterns via generalised additive mixed models.

Results
There was no difference in children’s mean MVPA in Wave 2 (weekdays: -2.3 min; 95% CI: -5.9, 1.3 and weekends: 0.6 min; 95% CI: -3.5, 4.6) when compared to the pre-COVID-19 data. Sedentary time remained higher than pre-pandemic by 13.2 min (95% CI:5.3, 21.1) on weekdays. Differences compared to pre-COVID-19 changed over time, with children’s MVPA decreasing over winter, coinciding with COVID-19 outbreaks, and only returning to pre-pandemic levels towards May/June 2022. Parents’ sedentary time and weekday MVPA was similar to pre-COVID-19 levels, with MVPA higher than pre-pandemic by 7.7 min (95% CI: 1.4, 14.0) on weekends.

Conclusion
After an initial drop, children’s MVPA returned to pre-pandemic levels by July 2022, while sedentary time remained higher. Parents’ MVPA remained higher, especially at weekends. The recovery in physical activity is precarious and potentially susceptible to future COVID-19 outbreaks or changes in provision, and so robust measures to protect against future disruptions are needed. Furthermore, many children are still inactive, with only 41% meeting UK physical activity guidelines, and so there is still a need to increase children’s physical activity.
Динаміка товарної структури штучних соснових деревостанів Слобожанського лісотипологічного району
Authors: Пастернак В. П. , Гірс О. А. , Гармаш А. В. 
Published: September 2023

Досліджено розподіл соснових деревостанів Слобожанського лісотипологічного району за походженням, типами лісу, повнотою та продуктивністю. Здійснено аналіз лісівничо-таксаційних показників на дослідних ділянках. Розглянуто таксаційну будову та товарну структуру соснових деревостанів регіону дослідження. Розраховано моделі мінливості діаметрів і відношення мінливості ділової частини до загальної мінливості діаметра деревостану з урахуванням мінімального та максимального діаметрів у модальних деревостанах. Виявлено залежність між часткою ділових стовбурів і віком модальних соснових деревостанів штучного походження. Побудовано таблиці динаміки товарної структури модальних соснових деревостанів із урахуванням розподілу об’ємів ділових стовбурів за класами й підкласами товщини, узгодженими з європейськими підходами щодо таксації круглих лісоматеріалів. Для складання нормативів застосовували нормативи ходу росту модальних сосняків штучного походження Лівобережного Лісостепу. Під час порівняння розроблених для Слобожанського лісотипологічного району нормативів з нормативами, розробленими для штучних соснових деревостанів Придонецького Степу, виявлено, що в останніх вихід ділової деревини нижчий у зв’язку з лісорослинними умовами регіону та станом деревостанів.
Динаміка реалізації ділової деревини в Україні під час воєнного стану
Authors: Жежкун І. М. 
Published: September 2023

Наведено перелік основних негативних наслідків війни для економіки лісового господарства України. Обґрунтовано доцільність використання вибіркового методу економічного аналізу під час війни та визначено пов’язані з нею ускладнення щодо отримання необхідної статистичної інформації. Розглянуто квартальну динаміку фізичних обсягів і цін реалізації сортиментів лісоматеріалів круглих сосни та дуба за чотирма (А, В, С, D) класами (діаметром 30–34 см, умови відпуску – франко-нижній склад і франко-ліс) упродовж 2022 р. за обласними управліннями лісового та мисливського господарства Державного агентства лісових ресурсів (ДАЛРУ) та здійснено порівняння з даними IV кварталу 2021 р. Визначено загальні тенденції змін і відмінності динаміки зазначених показників за підприємствами, підпорядкованими ДАЛРУ, за головними породами, класами якості та умовами відпуску деревини протягом першого року широкомасштабної військової агресії Росії в Україні.
Посухостійкість десяти клонів тополі на сході України
Authors: Висоцька Н. Ю. 
Published: September 2023

Інтерпретація реакції клонів тополь на дію дефіциту вологи дає можливість визначити найкращі гібридні комбінації для виявлення генотипів із високою стійкістю до посухи. Оцінено посухостійкість десяти клонів тополь у віці 7 років, які ростуть у сортовипробних культурах на сході України. Дослідження проведено в лабораторних умовах шляхом оцінювання вмісту води в тканинах листя, водного дефіциту, здатності листків утримувати воду та електропровідності. Клони 'Перспективна' (P. ? euroamericana cv. 'regenerata' ? P. lasiocarpa), 'Львівська' (P. ? euramericana cv. 'regenerata' ? P. trichocarpa), 'Ноктюрн' (P. trichocarpa ? P. lasiocarpa) виявилися стійкими до посухи. Клони 'Dorskamp' (P. ? euramericana var. Dorskamp) і 'Дружба' (P. trichocarpa ? P. laurifolia) були найменш посухостійкими. Гіпотезу про вищу посухостійкість клонів тополь, які культивують на сході України з 1960-х років, не підтверджено. Не виявлено залежності посухостійкості від гібридних комбінацій батьківських форм.
A Success Story of Cerebral Arteriovenous Malformation (AVM) Treated with Stereotactic Radiosurgery (SRS) in Bangladesh
Authors: Kumar Narendra , Yasmin Taohida , Appasamy Murugan , Rana KM Masud , Kumar R Arun , Joardar Aliuzzaman , Ahsan Sania , Alam Saiful 
Published: September 2023

Purpose: To share a case of cerebral Arteriovenous Malformation (AVM) patient, treated with Stereotactic Radiosurgery (SRS) at Evercare Hospital Dhaka, treatment process and successful outcome.
Background: Arteriovenous malformation is an anomaly, mostly congenital due to a misfit in vasculogenic, where arteries and veins come to a direct connection. Treatment options include observation, embolization, microsurgery, Stereotactic Radiosurgery (SRS) either alone or in combination. This report describes our experience in treating a patient of AVM by SRS. Stereotactic Radiosurgery is an established modality to achieve desired nidus obliteration, excellent compliance being noninvasive, and reduced treatment-related morbidity. This case report also reviewed the literature in detail. After a thorough literature search, to the best of our knowledge, this shall be the first published case report of AVM successfully treated with SRS in Bangladesh.
Case Presentation: In March 2019, 25-years old male presented in Radiation Oncology OPD as a diagnosed case of AVM, having complaints of headache for two years. Headache was occasional and often associated with vertigo and dizziness. He had no neurologic deficit. A radiological assessment revealed a large (4.6x4.4cm) AVM in the left parieto-occipital lobe showing serpiginous enhancement with IV contrast. After routine workup, he underwent stereotactic Radiosurgery in March’2019. A dose of 23Gy was delivered to the malformation, including all nidus. Acute radiation toxicity was noted as transient hair loss only over the irradiated area and no other side effect. Radiological Assessment was done at six months, 1year, and 2.5 years. After having a stable size at six months, complete nidus obliteration was achieved at one year. His last visit to our OPD was in July 2021, with radiologically complete nidus obliteration without any significant clinical symptoms.
Conclusions: Linear Accelerator-based SRS is an excellent treatment option for AVM, encouraging clinical outcomes for carefully selected patients.
Bang. J Neurosurgery 2022; 12(1): 53-64
Faktor-Faktor Yang Mempengaruhi Kelengkapan Imunisasi Dasar Pada Bayi Di Posyandu Dewi Sartika Kota Malang
Authors: Maemunah Neni , Susmini Susmini , Tuanany Nona N 
Published: September 2023

The reasons behind most of the mothers' refusal to fully immunize their children include a lack of understanding about the immunization process, including an ignorance of the recommended vaccination schedule, the value of immunization, the best time to immunize, and fear of adverse reactions. The study's purpose was to understand the factors that affect the basic vaccination of babies in Posyandu Dewi Sartika Kota Malang. This research is quantitative, with the research design being cross-sectional. The population of 40 mothers who have babies aged 0–12 months in Posyandu Dewi Sartika Kota Malang in 2021. Samples of 40 were recruited using total sampling techniques. The questionnaires were used to collect information about the mother's occupations, knowledge, attitudes, education, experience, health, and age. Data were analyzed using a multiple linear regression test (significance value of p 0,05). The results showed that the mother’s occupation (p = 0,031), knowledge (p = 0,005), attitude (p = 0,027), education (p = 0.031), experience (p = 0,022), health information, and age (p = 0,019) simultaneously influenced the completeness of basic immunization. The most dominant factor was the knowledge factor (p = 0,005). Further research to explore the effect of cultural factors and motivations of mothers when providing fully basic vaccinations to babies is expected.
Identification and Quantitative Determination of Flavonoids by HPLC-UV Method in the Raw Materials of Some Representatives of the Genus <i>Rumex</i> of Three Vegetation Time
Authors: Poluyanov A. M. , Sokolova A. Yu. , Koynova A.-D. , Kulikova S. D. , Malashenko E. A. , Bobkova N. V. 
Published: September 2023

Introduction. The study of the dynamics of accumulation of biologically active substances (hereinafter – BAS) in relation to the phonological phases of plant development is of great scientific and practical interest. The quantitative content of aglycones and glycosides of flavonoids depends on the life cycle of the plant and its vegetation phase.Aim. To identify and quantify flavonoids in the underground organs of Rumex confertus Willd., Rumex aquaticus L., Rumex crispus L. and Rumex obtusifolius L. harvested during different phases of vegetation.Materials and methods. Extracts from the underground organs of the studied plants, obtained according to the method from the pharmacopoeial article on R. confertus, were analyzed. Chromatographic separation and detection were performed on a Nexera-i LC-2040 high-performance liquid chromatograph (Shimadzu Corporation, Japan). The chromatograph was equipped with a column thermostat, chromatography column Grace HPLC-COLUMN 250 × 4.6mm platinum C8-EPS 5 mm (Grace, США) and Guard column Phenomenex SecurityGuardTM Cartridges Widepore C18 4 × 3,0 mm, a degasser, an autosampler (injection volume: 10 µl), and an ultraviolet detector. Detection was carried out at a wavelength λ = 365 ± 2 nm. Mobile phase contains 0.1 % phosphoric acid in water (v/v) (eluent A); acetonitrile (eluent B) with flow rate: 0.9 ml/min.Results and discussion. All studied objects were analyzed. The authenticity of the substances contained were confirmed using the external standard, and their quantitative content was determined. The discovered and quantified substances were: 3-O-rutinoside of quercetin (rutin), 3-O-rutinoside of isorhamnetin (narcissin), 3-O-glucoside of kaempferol (astragalin), luteolin, kaempferol and isorhamnetin. 7-O-glucoside of luteolin (cynaroside) and 7-O-beta-D-glucoside apigenin (cosmosiin) were not found. The aglycone luteolin had the biggest share in the total quantitative content of flavonoids. It is noted that this aglycone is contained in larger quantities in relation to other flavonoids in all studied objects, regardless of the phase of vegetation.Conclusion. In the process of the research, a method for the quantitative determination of flavonoids in alcohol-water extracts was developed. Aglycones and glycosides of flavonoids were identified and quantified in the underground organs of R. confertus Willd., R. aquaticus L., R. crispus L. and R. obtusifolius L. of three different vegetations.
Antiarrhythmic Activity of Amino Acids Containing Nibentan Derivatives in Case of Symptoms of Occlusive and Reperfusion Arrhythmias
Authors: Napalkova S. M. , Buyuclinskaya O. V. 
Published: September 2023

Introduction. Pharmacotherapy of cardiac arrhythmias is one of the urgent problems of modern medicine. The presence of serious side effects, in particular proarrhythmic action, limits the use of known antiarrhythmics in clinical practice. One way to reduce the toxicity of pharmacological agents is to use them as complex compounds with amino acids.Aim. Studying the effect of nibentan derivatives containing magnesium salt of L-aspartic acid and glycine as anions on the course of early occlusive and reperfusion arrhythmias.Materials and methods. Aminоacid derivatives of nibentan have been studied in models of occlusive and reperfusion arrhythmias in rats. The activity of the drugs was assessed by the incidence of ventricular extrasystoles (VEC), ventricular tachycardia (VT), ventricular fibrillation (VF), by the latent period and duration of arrhythmias, the average duration of VT, and by the number of VEC per 1 animal.Results and discussion. Nibentan derivatives in models of early occlusive and reperfusion arrhythmias were not inferior in antiarrhythmic activity to lidocaine and nibentan in their ability to prevent cardiac arrhythmias. The nibentan derivative containing the magnesium salt of L-aspartic acid (compound LHT-53-91) in the model of occlusive arrhythmias at a dose of 2 % LD50 completely prevented cardiac arrhythmias in experimental animals. A nibentan derivative containing glycine (compound LHT-20-92) at a dose of 1 % LD50 significantly reduced the number of cases of PVCs, prevented the occurrence of ventricular tachycardia and ventricular fibrillation in 100 % of cases. In the model of reperfusion arrhythmias, LHT-53-91 at a dose of 1 % LD50 prevented the development of ventricular fibrillation and paroxysms of ventricular tachycardia and reduced the risk of developing ventricular extrasystole (p < 0.05). Increasing the dose to 2 % LD50 led to an increase in the activity of the substance, which was expressed in the prevention of cardiac arrhythmias in 100 % of the animals. LHT-20-92 at a dose of 1 % LD50 in this model of cardiac arrhythmias statistically significantly reduced the occurrence of VES and VT paroxysms and completely prevented the occurrence of VF (p < 0.05).Conclusion. The inclusion of nibenthan amino acids in the structure, which shielded genotic grouping and reduced potential teratogenicity and mutagenicity, had not led to a reduction in the antiarrhythmic and antifibril-torn activity on the studied models of rhythm disorders.
The Quality Risk Assessment of Paralithodes Camtschaticus Collagenase Gel in the Process of Pharmaceutical Development
Authors: Ivankova Ju. O. , Sysuev B. B. , Evseeva S. B. 
Published: September 2023

Introduction. The manufacturing and application of enzyme preparations in the semisolid topical products has features associated with their lability. In previous studies, on the set of specifications the gel form was selected, containing aerosil and olive oil, in which the stabilization of collagenase from Paralithodes camtschaticus was ensured by lipophilic base. In the pharmaceutical development process, the drug critical quality attributes must be defined. Taking into account the lability of Paralithodes camtschaticus collagenase, the identification and minimizing risks аre relevant.Aim. The aim was the risk factors assessment and minimization during the pharmaceutical development of the gel, containing Paralithodes camtschaticus collagenase within the QbD concept.Materials and methods. The laboratory samples of gels, containing Paralithodes camtschaticus collagenase, were tested, using the analysis methods recommended by the SP RF 14th ed., as well as GOST 29188.3-91.Results and discussion. Based on the potential critical characteristics of the material, the pharmaceutical substance Paralithodes camtschaticus collagenase (particle size) and excipients (concentration and sorption properties of aerosil, oxidation of olive oil) risk factors were assessed, and potential measures to reduce these risks are considered. It was revealed that the substance particle size in its origin exceeds the norm and requires preliminary grinding. The aerosil content factor was reveal as critical. The sorption properties of aerosil were not affected the proteolytic and collagenolytic activity of the collgenase gel. It was proved that chemical instability of oil refers to critical factors and the antioxidants (alpha-tocopherol or butylhydroxytoluene) content was justified.Conclusion. In the course of the study, the Paralithodes camtschaticus collagenase gel the possible risks of pharmaceutical substances and excipients were theoretically justified in accordance with the QbD concept. An experimental assessment of their possible impact on the gel quality was given, which can improve the finished product quality during manufacturing manufacturing by eliminating the identified risks.
Development of the Composition and Technology of Tablets Based on <i>Astragalus membranaceus</i> (Fisch.) Bunge Dry Extract
Authors: Aroyan M. V. , Lohmatova D. E. , Vantorina D. D. , Novikova E. K. , Kaukhova I. E. , Nechaev M. V. 
Published: September 2023

Introduction. Human performance depends on external and internal factors. Of a number of external factors, the environmental aspect is one of the leading ones. Internal factors are interrelated with external ones. The latter include the general condition of the human body, as well as the normal functioning of individual systems and organs. It must be noted that the use of herbal drugs in order to prevent the development of pathologies caused by internal factors is rational. A number of plants contain substances that can improve performance by strengthening the cardiovascular system, normalizing the liver, adjusting daily rhythms, reducing stress. In this regard, the development of the composition and technology of drugs based on substances of plant origin does not lose relevance.Aim. Development of the composition of solid oral dosage form based on dry extract of Astragalus membranaceus (Fisch.) Bunge containing saponins.Materials and methods. As an object of research, a substance was used – dry extract of Astragalus membranaceus (Fisch.) Bunge, standardized in accordance with the requirements of SP XIV ed. Lactose monohydrate, calcium stearate, methylcellulose, corn starch, talc were used as excipients in the tablet technology. Under laboratory conditions, granulation was carried out by the wet mass extrusion method. A 3 % methylcellulose solution was used as the wetting reagent. Quality parameters of the final dosage form, tablets, were determined according to the methods described in SP XIV ed.Results and discussion. As a result of the conducted research, the composition of a solid oral dosage form based on a dry extract of Astragalus membranaceus (Fisch.) Bunge was proposed. The main quality indicators of the obtained dosage form are determined. A design quality specification has been developed for a drug.Conclusion. The present study proposed technology dry extract for Astragalus membranaceus (Fisch.) Bunge herb. Quality index of the obtained plant substance are determined. The composition and technology of tablets based on the dry extract of Astragalus membranaceus (Fisch.) Bunge herb have been developed. The main quality indicators of tablets based on the dry extract of Astragalus membranaceus (Fisch.) Bunge herb were determined. A draft quality specification of the resulting dosage form has been developed.
<i>Persicaria lapathifólia</i>: Identification, Chemical Composition, Pharmacological Action, Prospects for Use in Medical Practice (Review)
Authors: Gudkova A. A. , Chistyakova A. S. , Kostyleva A. A. , Bolgov A. S. , Slivkin A. I. 
Published: September 2023

Introduction. Knotweed (curlytop knotweed (curly pea)) – Persicaria lapathifólia Delarbre belongs to the buckwheat family Polygonaceae Juss., the genus Persicaria Mill. For a long time, the Persicaria lapathifólia did not exist as a separate species since 1989, the sorrel-leaved mountaineer has become an independent species. This is an annual herbaceous plant, repeating the main features of the genus Persicaria, and, as the main differences, having larger leaves, most often whitish-green flowers collected in dense inflorescences, peduncles and perianth of which have a large number of yellowish glands and a specific sweet smell.Text. Purpose of the work was to study the possible prospects for using the Persicaria lapathifólia as an official species. Currently, the plant is not used in medical practice and is considered an admixture in the collection of pharmacopoeial species of the genus Persicaria Mill. The plant is unpretentious to environmental conditions, is a weed, growing in absolutely all climatic zones, which indicates a rich procurement base. Despite the morphological similarity of the mountaineer sorrel with other species of the genus Persicaria, there is a sufficient amount of information in the literature regarding the identification of the object obtained as a result of a comprehensive morphological and anatomical assessment by microscopic methods (stereomicroscopy, luminescent microscopy, classical anatomy, petiolar anatomy), which allows a high the degree of reliability to eliminate errors in the procurement of raw materials and their further use. The chemical composition of Persicaria lapathifólia is represented by various classes of biologically active compounds, among which the most interesting are phenolic compounds (flavonoids), represented mainly by glycosides of quercetin and kaempferol. In addition, the plant is rich in vitamins, being a source of choline, organic and essential amino acids. Taking into account the peculiarities of the component composition of the mountaineer sorrel, the plant is considered as a source of phytopreparations with hemostatic, capillary-protective, antitumor, anti-inflammatory, antifungal effects.Conclusion. As a result of the generalization of the data available in the literature, the prospects of Persicaria lapathifólia to be introduced as a medicinal plant material and medicinal plant substance for the production of herbal medicines along with Persicaria maculosa and Persicaria hydropiper herb were revealed.