bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ten years of survival among early-stage breast cancer patients: a hospital-based study
Authors: Nahar Shamsun , Jamal Uddin  , Saidul Haque  , Nazir Uddin Mollah  , Sarwar Alam  , M. A. Bari  , Faruk Ahmed  , Khursheda Akhtar  , Mahmudur Rahman  
Published: February 2023

Background: The incidence rate of breast cancer is gradually increasing all over the world. In Bangladesh, we have very little research-based information regarding the survival of patients with early-stage breast cancer. The aim of this study was to determine the survival outcome of early-stage (Stages I- IIIA) breast cancer among female patients in respect to their age group, stage of the disease, tumor grade, nodal status, and hormone receptor status
Methods: This was a prospective observational study focused on the survival outcome conducted in the department of clinical oncology, Bangabandhu Sheikh Mujib medical university (BSMMU), Dhaka, Bangladesh during the period from December 2011 to December 2021. One hundred and five (105) female patients with early-stage (Stages I-IIIA) breast cancer were selected following the inclusion and exclusion criteria as the study subjects. Properly informed written consent was taken from all the participants before starting data collection. All data were processed, analyzed, and disseminated by MS office and SPSS programs as per need.
Results: The survival rate was found 79% (n=83). We observed stage-wise 10-year overall survival among the participants where 51.60%, 36.10%, and 12.30% survived from tumor stage I, II, and III respectively. We also observed that 29%, 60% and 11% of patients had survived from tumor grade I, II, and III respectively (Out of 83 survival cases). On the other hand, among the 83 10-year survival patients, 53.8% were of negative nodal status whereas 34.20% were of positive nodal status patients. Among the survived 83 patients, 86% were from >40 years’ age group whereas the rest 14% were from <40 years of age group.
Conclusions: Early detection and treatment of breast cancer provide a definitive survival benefit. The results of the study showed that comprehensive screening and early detection of breast cancer is required to improve the survival outcome.
Technique for Extraction and Revision of a Bent Intramedullary Nail for a Subtrochanteric Femur Fracture
Authors: Lam Aaron W. , Richardson David , Kang Kevin K. 
Published: February 2023

Case:
A 17-year-old adolescent boy presented 2 months after initial intramedullary nail (IMN) fixation of a comminuted subtrochanteric fracture with refracture at the previous site and approximately 20° varus angulation of the nail. The bent femoral nail was successfully extracted using an open technique using Lohman bone-holding clamps and a broad plate. At the 1-year follow-up, fracture union was achieved.

Conclusions:
Removal of a deformed IMN is rare. No standardized protocol exists in guiding orthopaedic surgeons. A thorough review of techniques is discussed on this unusual complication.
Multiple Myeloma in a Young Adult
Authors: Ryu Maya H. , Anderson Ashley B. , Potter Benjamin K. 
Published: February 2023

Case:
We present a 27-year-old man who presented with worsened back pain after a fall from a ladder. Unrelenting pain prompted the discovery through imaging and biopsy of a large pelvic plasmacytoma along with innumerable axial and appendicular lytic osseous lesions. The patient was soon thereafter diagnosed with light chain multiple myeloma (MM) and underwent measurable residual disease response-adapted consolidation treatment.

Conclusion:
The typical age at diagnosis for MM is 60 to 70 years. This case emphasizes the need to consider MM when diagnosing patients younger than 30 years, especially those with numerous bony lesions.
A Mendelian randomization study investigated the relationship between socioeconomic status and myocardial infarction
Authors: Liu Meijia , Sun Xueqing , Li Longbo , Wang Guan , Shi Yongfeng 
Published: February 2023

AbstractBackground:It is unclear whether socioeconomic factors causally affect cardiovascular disease risk. Utilizing data from comprehensive genetic associated studies of socioeconomic status (SES) and myocardial infarction (MI), we employed two-sample mendelian randomization (MR) analysis to determine the causality between SES and MI.Method:The genetic summary level data of SES and MI were acquired from various genome-wide association studies (GWAS) studies. We first identified instrumental variables of the socioeconomic determinants and then investigated the causality between instrumental variables and MI. The primary method employed to evaluate this causation was the conventional inverse variance weighted (IVW). Sensitivity analysis was used to assess the underlying heterogeneity and pleiotropy.Results:Age of full-time education has a reverse causal relationship with MI (OR 0.57, 95 percent CI 0.38-0.87, p=0.0096). There is a potential causal association between self-reported household income and the incidence of MI (OR 0.41, 95 percent CI 0.32-0.52, p=8.82×10-14). Additionally, Hard physical work is significantly associated with a higher risk of MI (OR 1.79, 95 percent CI 1.02-3.13, p= 0.042).Conclusions:The idea that low SES levels might raise the incidence of MI is supported by this MR study.
Identification of factors affecting using health information technology for hypertension management: A systematic review
Authors: Afshar Hadi lotfnezhad , Faezi Aysan , Rahimi Behlol 
Published: February 2023

Abstract

Background: Health information technology helps patients take better care of themselves and improves the health status of patients with chronic diseases, such as hypertension.Objective: we conducted this study with the aim of identifying factors affecting the use of health information technology in hypertension management.Methods: This is a systematic review study conducted in 2022. To obtain relevant articles, databases including Scopus, Web of Science, IEEE, and PubMed were searched and the time period was between 2013 and 2022. Initially, 827 articles were retrieved and after the screening, we selected 50 articles for inclusion in the study.Results: we can divide the factors affecting the use of health information technology in hypertension management into motivating and inhibiting factors and we can categorize each of them into five groups organizational, technical, economic, individual, and ethical/legal factors. Motivating factors include improving patient and service provider communication and increasing patient participation, remembering and providing voice reminders by technologies, saving money and time, and helping to keep personal identity and type of illness confidential (in situations where the patient wants to it is not to raise it with the doctor and others), quick and easy access to information and services and increasing the patient's adherence to treatment and medication. The inhibiting factors also included the increase in workload, resistance to change, lack of technical support and immediate resolution of technology problems, poverty and financial problems, privacy concerns, lack of motivation and interest, low knowledge and awareness (education), and lack of computer skills.Conclusion: Identifying motivating and inhibiting factors can help to better use technologies for hypertension management. Overall, this approach can improve the acceptability of these technologies and save costs, reduce the long-term complications of hypertension, and improve the quality of life of hypertension patients.
Nonlinear Catch-Up Growth in Height, Weight, and Head Circumference from Birth to Adolescence: A Longitudinal Twin Study
Authors: Womack Sean R. , Beam Christopher R. , Giangrande Evan J. , Scharf Rebecca J. , Tong Xin , Ponnapalli Medha , Davis Deborah W. , Turkheimer Eric 
Published: February 2023

Abstract
Owing to high rates of prenatal complications, twins are, on average, substantially smaller than population norms on physical measurements including height, weight, and head circumference at birth. By early childhood, twins are physically average. This study is the first to explore the process of catch-up growth by fitting asymptotic growth models to age-standardized height, weight, and head circumference measurements in a community sample of twins (n = 1,281, 52.3% female) followed at up to 17 time points from birth to 15 years. Catch-up growth was rapid over the first year and plateaued around the population mean by early childhood. Shared environmental factors accounted for the majority of individual differences in initial physical size (57.7%-65.5%), whereas additive genetic factors accounted for the majority of individual differences in the upper asymptotes of height, weight, and head circumference (73.4%-92.6%). Both additive genetic and shared environmental factors were associated with variance in how quickly twins caught up. Gestational age and family SES emerged as important environmental correlates of physical catch-up growth.
Geometrical control of topological charge transfer in Shakti-Cairo colloidal ice
Authors: Rodríguez-Gallo Carolina , Ortiz-Ambriz Antonio , Nisoli Cristiano , Tierno Pietro 
Published: February 2023

Abstract
Lattice transformations that preserve the system topology, but not its geometry, occur in a wide variety of systems across length scales. Here we show that, in an artificial colloidal ice, unlike in a magnetic spin ice, a geometric transformation between two mixed coordination lattices, from Shakti to Cairo, leads to a breakdown of the ice rule in all but one specific geometry. In general, there is a transfer of topological charge among sublattices, which can be controlled in sign and intensity, and becomes zero at the ice-rule point. These unusual topological effects, absent in magnetic spin ices, are due to the collective, non-local nature of geometric frustration in the particle ice. Via combined use of numerical simulations, theory and experiments, we demonstrate how the charge transfer occurs and how to control the accumulation, storage and release of topological monopoles. Thus, we show how to use geometric constraints in a mesoscopic colloidal system to control its topological properties.
Gene-based burden scores identify rare variant associations for 28 blood biomarkers
Authors: Aldisi Rana , Hassanin Emadeldin , Sivalingam Sugirthan , Buness Andreas , Klinkhammer Hannah , Mayr Andreas , Fröhlich Holger , Krawitz Peter , Maj Carlo 
Published: February 2023

Abstract
Background: A relevant part of the genetic architecture of complex traits is still unknown; despite the discovery of many disease-associated common variants. Polygenic risk score (PRS) models are based on theevaluation of the additive effects attributable to common variants and have been successfully implemented to assess the genetic susceptibility for many phenotypes. In contrast, burden tests are often used to identify an enrichment of rare deleterious variants in specific genes. Both kinds of genetic contributions are typically analyzed independently. Many studies suggest that complex phenotypes are influenced by both low effectcommon variants and high effect rare deleterious variants. The aim of this paper is to integrate the effect of both common and rare functional variants for a more comprehensive genetic risk modelling.
Methods: We applied a framework combining gene-based scores based on the enrichment of rare functionally relevant variant with genome-wide PRS based on common variants for association analysis and prediction models. We applied our framework on UK Biobank dataset with genotyping and exome data and considered 28 blood biomarkers levels as target phenotypes. For each biomarker, an association analysis was done on full cohort using gene-based scores (GBS). The cohort was then split into 3 subsets for PRS constuction and feature selection, predictive model training, and independent evaluation, respectively.prediction models were generated including either PRS, GBS or both (combined).
Results: Association analyses of the cohort were able to detect significant genes that were previously known to be associated with different biomarkers. Interestingly, the analyses also revealed heterogeneous effect sizes directionality highlighting the complexity of the blood biomarkers regulation. However, the combined models for many biomarkers show little or no improvement in prediction accuracy compared to PRS model.
Conclusion: This study shows that rare variants play an important role in the genetic architecture of complex multifactorial traits such as blood biomarkers. However, despite at individual level rare deleterious variant play a strong role, our results indicate that classical common variant based PRS might be more informative to predictthe genetic susceptibility at population level. Keywords: gene associations; blood biomarkers; genetic prediction; rare variants; PRS; complex phenotypes
Stem cell transcription factor OCT4 promotes cisplatin resistance in gastric cancer by upregulating DNA methyltransferase 1 (DNMT1)
Authors: Yan zhengzheng , Bu Xiaoqian , Chen Haixia , Ren Chongren , Li Ji , Wu Yongjie , Xing Jun 
Published: February 2023

Abstract
Purpose
To investigate the stem cell transcription factor OCT4 up-regulating DNA methyltransferase 1 (DNMT1) in the regulation of cisplatin (CDDP) resistance in gastric cancer (GC).
Methods
Human GC cell lines HGC-27 and MGC-803 were transfected with specific small interfering fragment siRNA-OCT4 to construct interfering cell lines. γ-H2AX immunofluorescence was used to detect DNA damage. The protein expressions of OCT4 and DNMT1 were detected by western blot and the effect of CDDP treatment on cell apoptosis and proliferation was detected by CCK8, cell cloning and flow cytometry.
Results
There is a targeted regulatory relationship between OCT4 and DNMT1. The expression of OCT4 and DNMT1 were significantly increased in CDDP induced cells, and the expression of DNMT1 was decreased in siRNA-OCT4 group. Compared with the siRNA-OCT4 group, the apoptosis of cells in the siRNA-OCT4 + CDDP group was increased, and the proliferation ability was decreased. Overexpression of DNMT1 reversed the effect of OCT4 on cisplatin sensitivity of gastric cancer cells.
Conclusions
The increased expression of OCT4 and the up-regulating of DNMT1 is associated with CDDP resistance in gastric cancer cells. Overexpression of OCT4 promoted DNMT1 expression and GC cell proliferation, induced cell apoptosis, and reduced CDDP resistance.
More than a Feeling: Dermatological Changes Impacted by Spaceflight
Authors: Cope Henry , Elsborg Jonas , Demharter Samuel , Mcdonald J. Tyson , Wernecke Chiara , Parthasarathy Hari , Unadkat Hriday , Chatrathi Mira , Claudio Jennifer , Reinsch Sigrid , Zwart Sara , Smith Scott , Heer Martina , Muratani Masafumi , Meydan Cem , Overbey Eliah , Kim JangKeun , Park Jiwoon , Schisler Jonathan , Mason Christopher , Szewczyk Nathaniel , Willis Craig , Salam Amr , Beheshti Afshin 
Published: February 2023

Abstract

Spaceflight poses a unique set of challenges to humans and the hostile spaceflight environment can induce a wide range of increased health risks, including dermatological issues. The biology driving the frequency of skin issues in astronauts is currently not well understood. To address this issue, we used a systems biology approach utilizing NASA’s Open Science Data Repository (OSDR) on spaceflown murine transcriptomic datasets focused on the skin, biomedical profiles from fifty NASA astronauts, and confirmation via transcriptomic data from JAXA astronauts, the NASA Twins Study, and the first civilian commercial mission, Inspiration4. Key biological changes related to skin health, DNA damage & repair, and mitochondrial dysregulation were determined to be involved with skin health risks during spaceflight. Additionally, a machine learning model was utilized to determine key genes driving spaceflight response in the skin. These results can be used for determining potential countermeasures to mitigate spaceflight damage to the skin.
RC48-ADC combined with tislelizumab as neoadjuvant treatment in patients with HER2 positive locally advanced muscle-invasive urothelial bladder cancer：A multi-center phase Ib/II study (HOPE-03)
Authors: Wen Feng , Lin Tianhai , Zhang Peng , Shen Yali 
Published: February 2023

Abstract
Background
Bladder cancer with Human Epidermal Growth Factor Receptor 2 (HER2) high expression is related to pathological malignancy and poor prognosis. The standard care for muscle-invasive urothelial bladder cancer (MIBC) is neoadjuvant chemotherapy (NAC) followed by radical cystectomy (RC) with pelvic lymph node dissection. For HER2 positive MIBC, the efficacy of cisplatin- based NAC is unsatisfied, and adverse reactions are inevitable or even intolerable. New regimens with higher efficiency and lower toxicity are needed to be explored in the neoadjuvant setting for this population.
Methods
HOPE-03 is a multi-center, open-label, single-arm, phase Ib/II study, aiming to evaluate the safety and efficacy of RC48-ADC (Distamab Vedotin, DV), a humanized anti-HER2 antibody conjugated with monomethyl auristatin E, and tislelizumab (PD-1 antibody) as a novel neoadjuvant treatment combination in patients with HER2 positive locally advanced urothelial MIBC. Fifty-one patients with cT2-4bN0-3M0-1a pathological and imaging diagnosed HER2 positive (Immunohistochemistry status 3 + or 2 + or 1+) MIBC will be recruited. Of them, 6 patients are enrolled in the dose-escalation phase (3 patients in RC48-ADC 1.5kg/m2 group and 3 patients in 2.0mg/kg group), and 45 patients enter into phase II study (the expected recommended phase II dose for RC48-ADC is 2.0mg/kg). Patients without disease progression will receive radical cystectomy or bladder-sparing therapies as their will after neoadjuvant treatment. The primary endpoints are clinical complete remission rate (cCR, T0/Ta/Tis), pathological complete remission rate (pCR) and safety. The secondary endpoints are overall survival (OS), local recurrence free survival (LRFS), distant metastasis free survival (DMFS) and quality of life.
Discussion
HOPE-03 trial will give a description about the safety profile of RC-48 and tislelizumab combination in the neoadjuvant treatment of HER2 positive locally advanced urothelial MIBC, and the efficacy will be explored as well in this population.
Giant room-temperature spin-orbit torque in a bismuthate superconductor
Authors: Edgeton Anthony , Harris Isaac , Campbell Neil , Chai Yahong , Mazur Marcel , Gurung Gautam , Huang Xiaoxi , Susarla Sandhya , Tsymbal Evgeny , Ralph Daniel , Nan Tianxiang , Rzchowski Mark , Ramesh Ramamoorthy , Eom Chang-Beom 
Published: February 2023

Abstract
The emergence of artificial intelligence and machine-learning-based systems, in conjunction with the pervasive implementation of the internet of things has put a strong emphasis on the energy efficiency of computing. This has triggered research on multiple pathways to improve computing efficiency, spanning 3-D integration of logic and memory as well as new, physics-based pathways including those embracing the electron’s spin degree of freedom, namely spintronics. Concurrently, the proposed integration of superconductivity and spintronics emphasizes complex oxides as a promising platform which in principle can integrate spin current manipulation and high temperature superconductivity within the same complex system. Here, we report giant spin-orbit torque (SOT) discovered in the normal state of a complex oxide superconductor, Ba(Pb,Bi)O3, which provides isotropic and easily manipulated superconducting properties. Using spin-torque ferromagnetic resonance (ST-FMR) and d.c. non-linear Hall measurements, we find a robust SOT efficiency exceeding unity and demonstrate current driven magnetization switching at current densities as low as \(4\times {10}^{5}\text{A}{\text{c}\text{m}}^{-2}\). The hybridized s-p orbital character at the Fermi energy makes this an unexpectedly large value. We postulate the presence of an unconventional SOT generation in bismuthate heterostructures and anticipate our results will trigger further exploration of such complex oxides for the development of superconducting spintronics.
Effects of the PERMA model-based psychological intervention on well-being and post- traumatic growth levels in young and middle-aged stroke patients
Authors: Zheng Zixiu , Song Runluo , Zhao Yunxiao , Lv Hongxia , Wang Yanqing , Yu Cong 
Published: February 2023

Abstract

BackgroundStroke is the number one cause of disability in young and middle-aged people, and positive psychology can provide additional recovery outcomes and is also crucial for the transition from hospital to home for stroke patients. However, there is a paucity of research on psychological interventions for young and middle-aged stroke patients during the rehabilitation period. Therefore, this study constructs a psychological intervention program based on the PERMA model of positive psychology and explores the impact of this program on patients' well-being and level of post-traumatic growth.MethodsOne hundred and twenty young and middle-aged stroke patients admitted to the rehabilitation medicine department of a tertiary care general hospital in Shenzhen, China, were selected, with 60 patients from 02–05–2022 as the control group and 60 patients from 05–08–2022 as the intervention group. Both groups received rehabilitation and conventional care, and the intervention group was given psychological intervention in the PERMA model on top of the control group for a total of 8 times over 4 weeks. The scores of Subjective Well-Being (IWB) and Post-Traumatic Growth Scale (PTG) were compared between the two groups before, after, 1 month after, and 3 months after the intervention.ResultsSubjective well-being (IWB) scores were significantly higher in the postintervention, 1-month post-intervention, and 3-month post-intervention groups than in the control group (t= 0.011, 0.000, 0.000;P<0.05); post-traumatic growth (PTG) scores were significantly higher in the post-intervention, 1-month post-intervention, and 3-month post-intervention groups than in the control group (t= 0.007, 0.000, 0.000;P< 0.01); repeated-measures ANOVAs were statistically significant (P<0.01) for the increase in well-being (IWB) and post-traumatic growth (PTG) scores over time for patients in the intervention group.ConclusionsThe PERMA model of psychological intervention can significantly improve the subjective well-being（IWB） and post-traumatic growth（PTG）of young and middle-aged stroke patients and is a positive and effective psychological intervention method.Trial RegistrationThis trial was registered on 01/02/2022 (registration number: 2022038004-FS01) and approved by the Clinical Research Ethics Committee of the Second People's Hospital of Shenzhen, China. The registration number of the Chinese Clinical Trials Registration Centeris ChiCTR2200060103.
A rare cause of air-leak syndrome in a premature newborn: a case report
Authors: Uzunhan Ozan , Yıldırım Mihriban Begüm , Eser Can , Öztarhan Kazım , Çelik Alaettin 
Published: February 2023

Abstract
Background: Pulmonary complications, such as airway leak syndrome, are common in preterm neonates; however, bronchial rupture is rarely seen.
Case Presentation: In this case, we present a preterm newborn who developed pneumomediastinum and pneumothorax. Although a thorax tube was placed, the pneumothorax persisted, requiring a thoracotomy to be performed to detect and treat the bronchial rupture.
Conclusion: Physicians should have a high suspicion of bronchial rupture in patients with persistent air leak syndrome even after thorax tube placement and continuous negative pressure implementation.