bluuebunny/crossref_metadata_2025_split huggingface dataset:
Registration of RU9601099 short‐grain rice germplasm
Authors: Wisdom D. K. A. , De Guzman C. T. , Moldenhauer K. A. K. 
Published: April 2023

AbstractThe University of Arkansas System Division of Agriculture Arkansas Agricultural Experiment Station released the germplasm of a short‐grain rice (Oryza sativa L.) known by its experimental designation RU9601099 (Reg. no. GP‐150, PI 701904). The line originated from the cross ‘Koshihikari’/’Mars’ (cross no. 900625), made at the Rice Research and Extension Center, Stuttgart, AR, in 1990. The RU9601099 line has an average yield of 7698 kg ha−1, excellent milling yield of 62/71 (% head rice/% total rice), and greater straw strength than either of its parents. The RU9601099 line provides a high‐yielding, lodging resistant, Japanese‐quality short‐grain rice line that is agronomically adapted to Arkansas growing conditions. These characteristics make this line beneficial for mid‐South producers to market rice to Japan.
Plasma concentration of atorvastatin metabolites correlates with low‐density lipoprotein cholesterol reduction in patients with coronary heart disease
Authors: Sverre E. , Munkhaugen J. , Kristiansen O. , Weedon‐Fekjær H. , Peersen K. , Gjertsen E. , Gullestad L. , Bergan S. , Husebye E. , Vethe N. T. 
Published: April 2023

AbstractIn this exploratory study from a randomized double‐blinded crossover trial including 70 patients with coronary heart disease and self‐perceived muscular side effects of statins, we aimed to determine the relationship between low‐density lipoprotein cholesterol (LDL‐C) reduction and atorvastatin metabolite plasma concentrations. All patients underwent a 7 weeks treatment period with atorvastatin 40 mg/day and a 7 weeks placebo period in random order. Nonlinear regression with a three‐parameter equation explored the relationship between percentage LDL‐C reduction (statin vs. placebo) and the pharmacokinetic variables. Mean LDL‐C reduction was 49% (range 12% to 71%). The sum of 4‐OH‐atorvastatin acid and lactone correlated moderately with the LDL‐C response (Spearman ρ 0.27, 95% confidence interval [CI]: 0.03 to 0.48). Accordingly, nonlinear regression showed R2 of 0.14 (95% CI: 0.03 to 0.37, R2 adjusted equaled 0.11). Even a perfect underlying correlation of 1.0 showed R2 = 0.32 by simulation, using historical intra‐individual LDL‐C variation (8.5%). The 90% inhibitory concentration was 2.1 nmol/L, and the 4‐OH‐metabolite sum exceeded this threshold in 34% of the patients. In conclusion, trough plasma concentrations of 4‐OH‐atorvastatin metabolites correlated moderately to the LDL‐C reduction. A plateau LDL‐C response was observed above a pharmacokinetic threshold, below which the response was highly variable. The usefulness of monitoring concentrations of atorvastatin metabolites to optimize the individual dosage have limitations, but its supportive potential may be pursued in relevant patient subsets to achieve adequate efficacy at the lowest possible dose. The results add knowledge to the overall understanding of the variable LDL‐C response mediated by atorvastatin.
Geniposidic acid attenuates DSS‐induced colitis through inhibiting inflammation and regulating gut microbiota
Authors: Jiang Peng , Zhang Yun , Li Xiaojie , Chen Junyang 
Published: April 2023

AbstractGeniposidic acid (GPA) is a bioactive compound isolated from Gardenia jasminoides Ellis (Rubiaceae) that has long been used to treat arthritis, jaundice, and hypertension. However, the therapeutic effects of GPA against colitis remain underexplored. This study aimed to investigate the effect of GPA on the remission of colitis and the underlying mechanisms. A DSS‐induced colitis mouse model was used to evaluate the influence of GPA on the modulation of gut microbiota and intestinal epithelial barrier function. Our results indicated that GPA improved DSS‐induced mouse colitis, including loss of body weight, disease activity index (DAI), colon length, and colonic pathological damage. DSS‐induced destruction of the intestinal barrier was also significantly repaired by GPA treatment. In addition, the relative levels of pro‐inflammatory cytokines, such as IL‐1β and TNF‐α, were markedly alleviated by GPA. Furthermore, western blot analysis revealed that GPA downregulated the protein expression of the nuclear transcription factor NF‐κB. Finally, we first demonstrated that GPA could alleviate gut microbiota dysbiosis in mice with colitis by bacterial 16S rRNA sequencing. In conclusion, our study demonstrates the therapeutic and protective effects of GPA on IBD and provides novel insights into the prevention of colitis by targeting gut microbiota metabolism using natural products.
No rest for resting spores: Can predators mitigate clubroot disease?
Authors: Schwelm Arne , Brennan Fiona , Geisen Stefan 
Published: April 2023

AbstractThe clubroot pathogen Plasmodiophora brassicae is a major and growing problem for the cultivation of Brassica crops. As conventional control disease management methods are ineffective or prohibited due to their ecological impact, and crop resistance is frequently broken, biological control of the pathogen has become a key focus for the development of sustainable agricultural systems. Here we provide a perspective review on the unexplored impact of soil microbiome predators, and their potential use as biocontrol agents, using clubroot disease as an example. We highlight several pathways by which microbiome predators can reduce clubroot in soils, including directly through predation and indirectly by inducing a clubroot‐suppressive microbiome. We further discuss how some microbiome predators might, in contrast, benefit clubroot disease spread through mechanisms such as phoresy toward hosts. We highlight that gaps in knowledge need to be filled that hinder wider application of microbiome predators against P. brassicae alone, and in combination with known biocontrol agents.
Cobalt Ferrite‐Gossypol Coordination Nanoagents with High Photothermal Conversion Efficiency Sensitizing Chemotherapy against Bcl‐2 to Induce Tumor Apoptosis
Authors: Zeng Yun , Liu Huifang , Ma Jingwen , Li Ke , Chang Peng , Wang Chenying , Li Lei , Chen Dan , Liu Changhu , Li Na , Zhan Wenhua , Zhan Yonghua 
Published: April 2023

AbstractGossypol is a chemotherapeutic drug that can inhibit the anti‐apoptotic protein Bcl‐2, but the existing gossypol‐related nanocarriers cannot well solve the problem of chemotherapy resistance. Based on the observation that gossypol becomes black upon Fe3+ coordination, it is hypothesized that encasing gossypol in glyceryl monooleate (GMO) and making it coordinate cobalt ferrite will not only improve its photothermal conversion efficiency (PCE) but also help it enter tumor cells. As the drug loading content and drug encapsulation efficiency of gossypol are 10.67% (w/w) and 96.20%, the PCE of cobalt ferrite rises from 14.71% to 36.00%. The synergistic therapeutic effect finally induces tumor apoptosis with a tumor inhibition rate of 96.56%, which is 2.99 and 1.47 times higher than chemotherapy or photothermal therapy (PTT) alone. PTT generated by the GMO nanocarriers under the irradiation of 808 nm laser can weaken tumor hypoxia, thereby assisting gossypol to inhibit Bcl‐2. In addition, the efficacy of nanocarriers is also evaluated through T2‐weighted magnetic resonance imaging. Observations of gossypol‐induced apoptosis in tissue slices provide definitive proof of chemotherapy sensitization, indicating that such coordination nanocarriers can be used as an effective preclinical agent to enhance chemotherapy.
Bamboo‐Inspired Structurally Efficient Materials with a Large Continuous Gradient
Authors: Mao Anran , Chen Jiewei , Bu Xiaochen , Tian Lulu , Gao Weiwei , Saiz Eduardo , Bai Hao 
Published: April 2023

AbstractBecause of its light weight and high strength, bamboo is used in many applications around the world. Natural bamboo is built from fiber‐reinforced material and exhibits a porous graded architecture that provides its remarkable mechanical performance. This porosity gradient is generated through the unique distribution of densified vascular bundles. Scientists and engineers have been trying to mimic this architecture for a very long time with much of the work focusing on the effect of fiber reinforcement. However, there still lacks quantitative studies on the role of pore gradient design on mechanical properties, in part because the fabrication of bamboo‐inspired graded materials is challenging. Here, the steep and continuous porosity gradient through an ingenious cellular design in Moso bamboo is revealed. The effect of gradient design on the mechanical performance is systematically studied by using 3D‐printed models. The results show that not only the magnitude of gradient but also its continuity have a significant effect. By introducing a continuous and large gradient, the maximum flexural load and energy absorption capability can be increased by 40% and 110% when comparing to the structure without gradient. These bamboo‐inspired cellular architectures can offer efficient solutions for the design of damage tolerant engineering structures.
Realizing Highly‐Ordered Laser‐Reduced Graphene for High‐Performance Flexible Microsupercapacitor
Authors: Zhao Yirong , Du Jingwei , Du Jiajun , Lu Qiongqiong , Mikhailova Daria , Yu Minghao , Pan Xiaojun 
Published: April 2023

AbstractLaser reduction of graphene oxide (GO) with direct‐write technology is promising to develop miniaturized energy storage devices because of highly flexible, mask‐free, and chemical‐free merits. However, laser reduction of GO is often accompanied with deflagration (spectacular and violent deoxygenating reaction), leading reduced graphene oxide (rGO) films into brittle and irregular internal structure which is harmful to the applications. Here, a pre‐reduction strategy is demonstrated to avoid this deflagration and realize a uniform laser‐reduced GO (LrGO) matrix for the application of flexible micro‐supercapacitors (MSCs).The pre‐reduction process with ascorbic acid decreases the content of oxygen‐containing functional groups on GO in advance, and thus relieves gases emission and avoids unconstrained expansion during the laser reduction process. In addition, a self‐assembled skeleton with pre‐reduced GO (PGO) nanosheets could be constructed which is a more appropriate aforehand framework for laser reduction to establish controllable rGO films with the homogenous porosity. The quasi‐solid‐state MSCs assembled with laser‐reduced PGO exhibit the maximum areal capacitance of 88.32 mF cm−2, good cycling performance (capacitance retention of 82% after 2000 cycles), and outstanding flexibility (no capacitance degradation after bending for 5000 times). This finding provides opportunities to enhance quality of LrGO which is promising for micro‐power devices and beyond.
Filler‐Enhanced Piezoelectricity of Poly‐L‐Lactide and Its Use as a Functional Ultrasound‐Activated Biomaterial
Authors: Vukomanović Marija , Gazvoda Lea , Kurtjak Mario , Maček‐Kržmanc Marjeta , Spreitzer Matjaž , Tang Qiao , Wu Jiang , Ye Hao , Chen Xiangzhong , Mattera Michele , Puigmartí‐Luis Josep , Pane Salvador Vidal 
Published: April 2023

AbstractPoly‐L‐lactide (PLLA) offers a unique possibility for processing into biocompatible, biodegradable, and implantable piezoelectric structures. With such properties, PLLA has potential to be used as an advanced tool for mimicking biophysical processes that naturally occur during the self‐repair of wounds and damaged tissues, including electrostimulated regeneration. The piezoelectricity of PLLA strongly depends on the possibility of controlling its crystallinity and molecular orientation. Here, it is shown that modifying PLLA with a small amount (1 wt%) of crystalline filler particles with a high aspect ratio, which act as nucleating agents during drawing‐induced crystallization, promotes the formation of highly crystalline and oriented PLLA structures. This increases their piezoelectricity, and the filler‐modified PLLA films provide a 20‐fold larger voltage output than nonmodified PLLA during ultrasound (US)‐assisted activation. With 99% PLLA content, the ability of the films to produce reactive oxygen species (ROS) and increase the local temperature during interactions with US is shown to be very low. US‐assisted piezostimulation of adherent cells directly attach to their surface (such as skin keratinocytes), stimulate cytoskeleton formation, and as a result cells elongate and orient themselves in a specific direction that align with the direction of PLLA film drawing and PLLA dipole orientation.
KIF15 knockdown inhibits the development of endometrial cancer by suppressing epithelial‐mesenchymal transition and stemness through Wnt/β‐catenin signaling
Authors: Huang Jie , Sun Xinwei , Diao Ge , Li Runbo , Guo Jianxin , Han Jian 
Published: April 2023

AbstractEndometrial cancer (EC) is one of the most common cancers among women, while the incidence of EC is rising. Many studies have found that Kinesin family member 15 (KIF15) is highly expressed in a series of cancers, but the role of KIF15 in EC is unclear. We detected the expression level of KIF15 in a microarray of EC tissues by immunohistochemical staining (IHC), and analyzed the correlation between the expression level of KIF15 and the pathological characteristics of patients. After inhibit the expression of KIF15 in EC cells with lentivirus, cell proliferation and apoptosis were detected respectively by CCK8 assay, flow cytometry and tunnel assay. Transwell assay and wound healing assay were used to examine the migration ability and invasion ability of EC cells. Spheroid formation assay was used to evaluate cell self‐renewal ability. In vivo tumor xenograft model was used for validation. The expressions of epithelial‐mesenchymal transition, cancer stem cells, and Wnt/β‐catenin signaling molecules were detected by Western blotting. The results showed that the expression of KIF15 in EC tissues was higher than that in normal endometrial tissues, while the expression level of KIF15 in EC was positively correlated with the pathological grade of the tumor. The down‐regulation of KIF15 reduced the proliferation, colony formation, invasion, migration and self‐renewal ability of EC cells, while promoted cell apoptosis. Knockdown of KIF15 inactivates the Wnt/β‐catenin signaling of EC cells, inhibitors of Wnt signaling can counteract the enhanced self‐renewal ability caused by KIF15 overexpression. Therefore, KIF15 may be a new potential target for diagnosis and treatment of EC.
Anaesthesia, analgesia and cardiovascular support in a Kunekune pig undergoing a complicated umbilical hernia repair
Authors: Dagnall Clare , Deutsch Julia 
Published: April 2023

AbstractThis report describes the peri‐operative anaesthesia and analgesia management of a 5‐year‐old Kunekune pig undergoing surgical correction of an umbilical hernia. Premedication with azaperone (1 mg/kg), xylazine (0.5 mg/kg), butorphanol (0.2 mg/kg) and ketamine (5 mg/kg) intramuscularly preceded induction of anaesthesia with ketamine (2 mg/kg) intravenously. General anaesthesia was maintained with isoflurane in 100% oxygen. Analgesia was supported intraoperatively by a transversus abominis plane block with lidocaine (1.5 mg/kg), and a ketamine (10 μg/kg/min) infusion intravenously. Crystalloid fluid boluses and atropine intravenously were administered, and mechanical ventilation was stopped to aid correction of hypotension. Post‐operative analgesia was supported with a continuous infusion of ketamine (5 μg/kg/min) intravenously, butorphanol (0.2 mg/kg) intravenously every 6 hours, paracetamol (10 mg/kg) intravenously orally every 8 hours and meloxicam (0.4 mg/kg) intravenously orally every 24 hours. The pig made progressive clinical improvement and was discharged 7 days after the surgery.
Subgroup analysis and adaptive experiments crave for debiasing
Authors: Wang Jingshen , He Xuming 
Published: April 2023

AbstractResults obtained from reliably designed randomized experiments are often considered to be evidence of the highest grade for assessing the effectiveness of biomedical or behavioral interventions. Nevertheless, even with randomized experiments, statistical bias can arise in post hoc analysis of the data or through adaptive data collection. In this article, we discuss the need for and review some of the recent developments in statistical methodologies to address the issue of potential bias in adaptive experiments and in subgroup analysis. For adaptive experiments, we focus on adaptive treatment assignments. For subgroup analysis, we focus on post hoc subgroup selection and review several frequentist approaches for debiased inference on the best‐selected subgroup effects.This article is categorized under:Applications of Computational Statistics > Clinical Trials
Carbon dots: Types, preparation, and their boosted antibacterial activity by photoactivation. Current status and future perspectives
Authors: Lagos Karina J. , García David , Cuadrado Coralía Fabiola , de Souza Larissa Marila , Mezzacappo Natasha Ferreira , da Silva Ana Paula , Inada Natalia , Bagnato Vanderlei , Romero María Paulina 
Published: April 2023

AbstractCarbon dots (CDs) correspond to carbon‐based materials (CBM) with sizes usually below 10 nm. These nanomaterials exhibit attractive properties such us low toxicity, good stability, and high conductivity, which have promoted their thorough study over the past two decades. The current review describes four types of CDs: carbon quantum dots (CQDs), graphene quantum dots (GQDs), carbon nanodots (CNDs), and carbonized polymers dots (CPDs), together with the state of the art of the main routes for their preparation, either by “top‐down” or “bottom‐up” approaches. Moreover, among the various usages of CDs within biomedicine, we have focused on their application as a novel class of broad‐spectrum antibacterial agents, concretely, owing their photoactivation capability that triggers an enhanced antibacterial property. Our work presents the recent advances in this field addressing CDs, their composites and hybrids, applied as photosensitizers (PS), and photothermal agents (PA) within antibacterial strategies such as photodynamic therapy (PDT), photothermal therapy (PTT), and synchronic PDT/PTT. Furthermore, we discuss the prospects for the possible future development of large‐scale preparation of CDs, and the potential for these nanomaterials to be employed in applications to combat other pathogens harmful to human health.This article is categorized under:
Therapeutic Approaches and Drug Discovery > Nanomedicine for Infectious Disease
New Digital Work and Digital Sovereignty at the Workplace – An Introduction
Authors: Hartmann Ernst Andreas , Shajek Alexandra 
Published: April 2023

AbstractIn this chapter, a framework will be presented for analyzing and designing work systems for digital sovereignty, based on sources from action regulation, control (in the psychological sense), and sociotechnical systems theories. The individual contributions of this edited volume are then classified on the basis of this framework. After discussing specific effects regarding the technology, people, and organization dimensions of digital sovereignty, some more overarching or cross-cutting aspects shall be presented. The chapter concludes with some background information on the history of this publication, which is part of a tradition of contributions on the future of (digital) work.
Human-Machine-Interaction in Innovative Work Environment 4.0 – A Human-Centered Approach
Authors: Kreuzwieser Simon , Kimmig Andreas , Michels Felix , Bulander Rebecca , Häfner Victor , Bönsch Jakob , Ovtcharova Jivka 
Published: April 2023

AbstractThe working environment is constantly changing and companies face the challenge of adapting to new and constantly changing customer requirements. Employees are faced with the challenge of identifying and learning new, helpful technologies and using them in order to achieve efficiency gains and increase productivity. This article addresses the three technologies Artificial Intelligence, Robotic Process Automation and Virtual Reality, which will play an important role in the future of work and will influence the Work Environment 4.0. Artificial Intelligence and Robotic Process Automation relieve employees of repetitive and manual tasks which thus accelerate and simplify business processes. Virtual Reality offers employees new opportunities to collaborate in virtual environments. Instead of performing routine tasks, employees will increasingly promote the use of such technologies in future and orchestrate their application. In addition, it is important for employees to continuously look for new use cases within their own organization and to collaborate with external partners. The article aims to describe the opportunities that arise from the application of the technologies and to explain their effects on the Work Environment 4.0 and the employee.
Lund multiplicity in QCD jets
Authors: Medves Rok , Soto-Ontoso Alba , Soyez Gregory 
Published: April 2023

Abstract
We compute the average Lund multiplicity of high-energy QCD jets. This extends an earlier calculation, done for event-wide multiplicity in e+e− collisions [1], to the large energy range available at the LHC. Our calculation achieves next-to-next-to-double logarithmic (NNDL) accuracy. Our results are split into a universal collinear piece, common to the e+e− calculation, and a non-universal large-angle contribution. The latter amounts to 10–15% of the total multiplicity. We provide accurate LHC predictions by matching our resummed calculation to fixed-order NLO results and by incorporating non-perturbative corrections via Monte Carlo simulations. Including NNDL terms leads to a 50% reduction of the theoretical uncertainty, with non-perturbative corrections remaining below 5% down to transverse momentum scales of a few GeV. This proves the suitability of Lund multiplicities for robust theory-to-data comparisons at the LHC.
The mixed-state entanglement in holographic p-wave superconductor model
Authors: Yang Zhe , Cheng Fang-Jing , Niu Chao , Zhang Cheng-Yong , Liu Peng 
Published: April 2023

Abstract
In this paper, we investigate the mixed-state entanglement in a model of p-wave superconductivity phase transition using holographic methods. We calculate several entanglement measures, including holographic entanglement entropy (HEE), mutual information (MI), and entanglement wedge cross-section (EWCS). Our results show that these measures display critical behavior at the phase transition points, with the EWCS exhibiting opposite temperature behavior compared to the HEE. Furthermore, we explore the behavior of thermodynamics and holographic quantum information at the zeroth-order phase transition point and find that it is opposite to that observed in the first-order phase transition. Additionally, we find that the critical exponents of all entanglement measures are twice those of the condensate. Our findings also suggest that the EWCS is a more sensitive indicator of the critical behavior of phase transitions than the HEE. Lastly, we uncover a universal inequality in the growth rates of EWCS and MI near critical points in thermal phase transitions, such as p-wave and s-wave superconductivity, suggesting that MI captures more information than EWCS when a phase transition first occurs.
On Bethe eigenvectors and higher transfer matrices for supersymmetric spin chains
Authors: Lu Kang 
Published: April 2023

Abstract
We study the $$ {\mathfrak{gl}}_{m\mid n} $$

gl

m
∣
n

XXX spin chains defined on tensor products of highest weight $$ {\mathfrak{gl}}_{m\mid n} $$

gl

m
∣
n

-modules. We show that the on-shell Bethe vectors are eigenvectors of higher transfer matrices and compute the corresponding eigenvalues. Then we take the classical limits and obtain the corresponding results for the $$ {\mathfrak{gl}}_{m\mid n} $$

gl

m
∣
n

Gaudin models.