bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lithofacies, Deposition, and Clinoforms Characterization Using Detailed Core Data, Nuclear Magnetic Resonance Logs, and Modular Formation Dynamics Tests for Mishrif Formation Intervals in West Qurna/1 Oil Field, Iraq
Authors: Al-Dujaili Ahmed N. , Shabani Mehdi , Al-Jawad Mohammed S. 
Published: April 2023

Summary
This study considered the complexity of Mishrif geology and its effect on fluid movement within and across Mishrif reservoir intervals. For this purpose, we analyzed the following items: the multiple interval communication with high permeability contrast, the geological setting of the upper Mishrif (mA) interval, the channel structure in the Lower Mishrif-Part 1 (mB1) interval, the thin layers in the upper part of Lower Mishrif-Part 2 (mB2U) of very high permeability, and the microporous interval of the lower part of Lower Mishrif-Part 2 (mB2L); none of them were well defined before this work. The bottom interval of Mishrif or Rumaila (mC) is predominantly microporous, and the best reservoir is at the top of intermediate quality. Two high-porosity layers are systematically found in the mC unit, which is casually referred to as “rabbit ears.” The mB2L contains grainstones in the far north of the West Qurna/1 oil field (WQ1). In the south of mB2L, some of the toe sets from the clinoforms in a distal depositional setting have developed into rather important vertical pressure baffles and barriers to vertical flow.
The mB2U generally consists of grainstones with thin streaks of mudstone high flow layers (HFLs), and the rocks underneath are described generally as grainstone shoals. About 80% of stock tank oil originally in place (STOOIP) in mB2U exists in grainstones. There are no known microporous reservoirs in mB2U. The pressure difference across the boundaries between mB1 and mA can be positive or negative. At the base, mB1 channels are always in pressure communication with the mB2U below. The best flow from the mA comes from HFLs, which are found around faults. Reservoir quality within mA is generally best in the first section of the upper Mishrif (mAa), and the majority of STOOIP in mA exists in microporous rocks, while some 30% of STOOIP is contained in grainstones.
In-Depth Laboratory Proppant Transport Study Using HVFRs for Marcellus High TDS Environments
Authors: Biheri Ghith , Imqam Abdulmohsin 
Published: April 2023

Summary
Excellent proppant transport can be accomplished by introducing high-viscosity friction reducer (HVFR) fracture fluids. However, HVFRs face several challenges that prevent these fluids from providing good proppant transport performance, including the presence of total dissolved solids (TDS) in the produced water. TDS can negatively impact the viscous and elastic properties of HVFR. This study evaluated the rheological and proppant transport performance using HVFRs at extreme salinity conditions using water samples from the Marcellus Basin. The anionic and cationic HVFRs with a concentration of 4 gpt were used. Experimental evaluation work, including the rheology, static proppant settling measurements, and dynamic proppant transport, was conducted using three Marcellus TDS concentrations (68,000; 137,000; and 229,000 ppm). All the experiments were performed at a high-temperature condition that mimics the Marcellus reservoir temperature of 65.5°C (150°F). The results show that the existence of TDS was largely impacted by both types of HVFRs, but the cationic HVFR exhibited better resistance to the Marcellus TDS compared to the anionic HVFR in terms of transporting proppant. The viscosity of the anionic HVFR was reduced more than that of the cationic HVFR, as TDS concentrations increased to 229,000 ppm. However, the elasticity of both HVFRs was weak, as a switch was made from using low TDS to high TDS. This could imply that HVFR viscosity provides the main contribution to proppant transport in high TDS environments. Therefore, it is crucial to evaluate the impact of TDS on the effectiveness of HVFR by investigating HVFR rheology, static proppant settling, and dynamic proppant transport in the TDS environment.
The volatilome reveals microcystin concentration, microbial composition, and oxidative stress in a critical Oregon freshwater lake
Authors: Collart Lindsay , Jiang Duo , Halsey Kimberly 
Published: April 2023

Abstract
Toxins commonly produced by cyanobacterial blooms in freshwater lakes are a serious public health problem. The conditions leading to toxin production are currently unpredictable, thereby requiring expensive sampling and monitoring programs globally. We explored the potential of volatile organic compounds (VOCs) to indicate microcystin presence and concentration, and microbial community composition in Upper Klamath Lake, OR. Elastic net regularization regression selected 29 of 229 detected m/z+1 values (corresponding to unique VOCs) in models predicting microcystin toxicity that outperformed or significantly improved upon regression models based on environmental parameters, including chlorophyll, pH, and temperature. Several m/z+1 values selected by elastic net were putatively identified as saturated fatty aldehydes (SFAs), which are important in defending cyanobacteria against oxidative stress. Unique sets of m/z+1 values were also identified by elastic net regression that predicted the relative abundance of the most dominant bacterial phyla, classes, and cyanobacterial genera. These results show that VOCs may be a key component of lake monitoring strategies.
Quantitative and clinical implications of the EARL2 versus EARL1 [18F]FDG PET-CT performance standards in head and neck squamous cell carcinoma
Authors: Cox Maurice C. , Jurcka Tijn , Arens Anne I.J. , Rijk Maartje C. van , Kaanders Johannes H.A.M. , Bosch Sven van den 
Published: April 2023

Abstract
Background: The EANM Research Ltd. (EARL) guidelines give recommendations for harmonization of [18F]FDG PET-CT image acquisition and reconstruction, aiming to ensure reproducibility of quantitative data between PET scanners. Recent technological advancements in PET-CT imaging resulted in an updated version of the EARL guidelines (EARL2). The aim of this study is to compare quantitative [18F]FDG uptake metrics of the primary tumor and lymph nodes in patients with head and neck squamous cell carcinoma (HNSCC) on EARL2 versus EARL1 reconstructed images and to describe clinical implications for nodal staging and treatment.Methods: Forty-nine consecutive patients with HNSCC were included. For all, both EARL1 and EARL2 images were reconstructed from a singular [18F]FDG PET-CT scan. Primary tumors and non-necrotic lymph nodes ≥ 5mm were delineated on CT-scan. In the quantitative analysis, maximum standardized uptake values (SUVmax) and standardized uptake ratios (SURmax, i.e. SUVmax normalized to cervical spinal cord uptake) were calculated for all lesions on EARL1 and EARL2 reconstructions. Metabolic tumor volume (MTV) and total lesion glycolysis (TLG) were compared between EARL1 and EARL2 using different segmentation methods (adaptive threshold; SUV2.5/3.5/4.5; SUR2.5/3.5/4.5; MAX40%/50%). In the qualitative analysis, each lymph node was scored independently by two nuclear medicine physicians on both EARL1 and EARL2 images on different occasions using a 4-point scale.Results: There was a significant increase of SUVmax (19%) and SURmax (11%) of primary tumor and lymph nodes on EARL2 versus EARL1 imaging (p < 0.001). The proportional difference of both SUVmax and SURmax between EARL2 and EARL1 decreased with increasing tumor volume (p < 0.001). Absolute differences in MTVs between both reconstructions were small (< 1.0cm3), independent of the segmentation method. Relative differences in MTVs and TLGs were small using the adaptive threshold method and larger using static SUV or SUR thresholds. With visual scoring of lymph nodes 38% (11/29) of nodes with score 2 on EARL1 were upstaged to score 3 on EARL2, which resulted in an alteration of nodal stage in 18% (6/33) of the patients.Conclusions: Using the EARL2 method for PET image reconstruction resulted in higher SUVmax and SURmax compared to EARL1, with nodal upstaging in a significant number of patients.
Surgical Outcome in MCL and Extensor Mechanism Disruption Following Trauma in 80 years Old Post Total Knee Arthroplasty Spondyloarthropathic Patient: A Case Report
Authors: Bhattacharjee Sujoy , Mehta Abhishek , Jamshed Mohammad 
Published: April 2023

Abstract
Introduction: Ankylosing spondylitis (AS) is characterized by osteoproliferation-induced axial skeleton and sacroiliac joint damage that leads to spinal deformity and functional disability; up to 70% of patients have knee and other joints involvement and may require total joint replacement despite adequate pharmacological support Total knee arthroplasty (TKA) is an effective procedure in AS patient but very little has been reported on the outcomes. But the peculiar gait pattern due to ankylosed joints, which do not improve substantially after TKA, increases the incidence of falls, leading to complications.Case presentation: An 80-year-old Asian male with Primary TKA suffers extensor mechanism disruption and medial collateral ligament injury after a fall and undergoes Rotating hinge knee and patellar tendon repair augmented with semi-t graft. The patient could initially achieve early weight-bearing with splint support, later with the cylindrical cast.Conclusion Rotating Hinge Knee is a viable option in low-demand patients with good outcomes in patients with collateral ligament rupture. Semi-T augmented PT repair reinforced with suture anchors gives the relatively best result.
Effects of axial elongation on ganglion cell complex thickness and retinal capillary density in the peripheral retina among highly myopic eyes
Authors: Wang Deming , Zhang Yinhang , Lin Fengbin , Song Yunhe , Jin Ling , Wang Zhenyu , Chen Meiling , Jiang Jiaxuan , Wang Peiyuan , Yang Zefeng , Li Fei , Zhang Xiulan 
Published: April 2023

Abstract
Background/Objectives: To investigate the effects of axial elongation on ganglion cell complex (GCC) thickness and retinal capillary density (CD) in the circular region (12 mm diameter) using wide-field swept-source optical coherence tomography angiography.
Subjects/Methods: This retrospective and cross-sectional study included 506 eyes. Fovea-centred 15 × 12 mm² scans were acquired to measure the subregional GCC thickness and CD in the whole retina, superficial capillary plexus (SCP) and deep capillary plexus (DCP) among three groups: normal controls, high myopia (HM) eyes with an axial length (AL) <28 mm, and HM eyes with an AL >28 mm. The magnitude of GCC thickness and retinal CD changes with axial elongation was estimated using multivariable linear regression models.
Results: The GCC thickness and retinal CD in HM eyes with an AL >28 mm were lesser than those in the other two groups in most regions (P<0.05). In HM eyes with an AL <28 mm, GCC beyond the 3 × 3 mm² area was generally thinner than that in normal controls (P<0.05), while a significant reduction in CD occurred only in the 9–12 mm whole retina, 9–12mm superior SCP and 6–12 mm DCP (P<0.05). The GCC thickness and retinal CD with axial elongation demonstrated the greatest reduction in the subregions beyond 6 × 6 mm².
Conclusions: GCC thickness beyond the 3 × 3 mm² area and peripheral retinal CD beyond the 6 × 6 mm² area were more susceptible to axial elongation, thereby deserving particular attention.
The Effects of Pelvic Floor and Abdominal Muscle Training in Urinary Incontinence According to Severity
Authors: EROĞLU Havva Sümeyye , HALATCI Emine İPEK , ŞEN İlker , KESER İlke 
Published: April 2023

Abstract

The aim of this study is to investigate the effect of incontinence severity on pelvic floor and abdominal muscle strengthening training in women with stress urinary incontinence (UI). Sixteen patients with stress and mixed UI were included in the study. According to 24-hour pad test (24hPT), individuals were divided into two groups as group 1 (24hPT 4-20gr, mild group, n: 9) and group 2 (21g and above in 24hPT, moderate-severe group, n: 7). Pelvic Floor Muscle Training (PFMT) and Abdominal Muscle Training were applied to the groups for 6 weeks. Urinary incontinence, pelvic floor muscle strength measurement, quality of life, symptom, and the presence of pelvic floor dysfunction (PFD) were evaluated respectively using 24hPT, Electromyography (EMG) Biofeedback device, King’s Health Questionnaire (KHQ), Urogenital Distress Inventory (UDI-6), and Global Pelvic Floor Bother Questionnaire (GPFBQ). Evaluations were performed at the beginning and at the end of the physiotherapy program, and subjective improvement rate was determined. After treatment, 24hPT values decreased in groups, but this decrease was only significant in group 2 (p < 0.05). The results obtained from this study showed that there was no difference between mild and moderate-severe groups in terms of having benefit from strengthening training to the pelvic floor and abdominal muscles. It was proved that, an increase in pelvic floor muscle strength, and quality of life, a decrease in UI symptoms and PFD might be achieved with physiotherapy application regardless of the severity of UI, and improvements in subjective recovery rate were provided. NCT05549193, 22/09/2022, retrospectively registered
Use of organic acids in micropropagation helps the production of salinity tolerant strawberry
Authors: de Oliveira Eduarda , Nadal Michele , Rodriguesa Filipe Almendagna , Santos Heloisa Oliveira dos , de Sousa Lilian Ferreira , Martins Adalvan Daniel , Sepúlveda Ana Milena Gómez , Dória Joyce , Pasqual Moacir 
Published: April 2023

Abstract

Abiotic stresses cause numerous harms to crops, such as limited growth and reduced yield, salt stress being one of the main culprits. The search for plants that are more tolerant to abiotic stresses is necessary to increase yield. The objective of this study was to investigate whether humic and fulvic acids inserted in vitro promote salt stress tolerance in strawberry plants. Salt stress was induced in plants in vitro, as well as the insertion of humic and fulvic acids. After this process, the plants were taken to the greenhouse and grown under stress to determine the efficiency of the process. The in vitro concentration of NaCl used caused stress in the plants. It was observed that the concentrations of humic acid and fulvic acid influenced the increase in the activity of the plant's antioxidant system in response to the NaCl applied during the growth of seedlings in a greenhouse. Therefore, plants grown in the presence of humic acid or fulvic in vitro acid respond to abiotic stress more quickly, suggesting that humic substances can be used to produce strawberries that are more tolerant to salt stress.
Th2/Th17 cell associated cytokines found in seroma fluids after breast cancer surgery
Authors: Pochert Nicole , Schneider Mariella , Köpke Melitta B , Wild Carl Mathis , Mattmer Angelika , Sagasser Jacqueline , Golas Monika M , Banys-Paluchowski Maggie Maggie , Metz Aline , Hinske Christian , Reiger Matthias , jeschke udo , Dannecker Christian , Neumann Avidan , Traidl-Hoffmann Claudia , Untch Michael , Kühn Thorsten , Ditsch Nina 
Published: April 2023

Abstract
Purpose The development of a seroma after breast cancer surgery is a common postoperative complication seen after simple mastectomy and axillary surgery. We could recently demonstrate that breast cancer patients undergoing a simple mastectomy with subsequent seroma formation developed a T helper cell increase within the aspirated fluid measured by flow cytometry. The same study revealed a Th2 and/or a Th17 immune response in peripheral blood and seroma fluid of the same patient. Based on these results and within the same study population, we now analyzed the Th2/Th17 cell associated cytokine content as well as the best known clinical important cytokine IL6.Methods Multiplex cytokine measurements (IL4, IL-5, IL-13, IL-10, IL17, and IL-22) were done on 34 seroma fluids (Sf) after fine needle aspiration of patients who developed a seroma after a simple mastectomy. Serum of the same patient (Sp) and of healthy volunteers (Sc) were used as controls.Results We found the Sf to be highly cytokine rich. Almost all analyzed cytokines were significantly higher in abundance in the Sf compared to Sp and Sc, especially IL-6, which promotes Th17 differentiation as well as suppresses Th1 differentiation in favour of Th2 development.Conclusion Our Sf cytokine measurements reflect a local immune event. In contrast, former study results on T-helper cell populations in both Sf and Sp tend to demonstrate a systemic immune process.
The healing capacity and osteogenesis pattern of Demineralized Dentin Matrix (DDM)-Fibrin Glue (FG) compound
Authors: Bao Jibo , Fu Xunan , Wu Yirong , Yang Shengyin , Ren Xiaobin , Fang Xingchen , Yuan Quan , Xie Zhigang , Seriwatanachai Dutmanee 
Published: April 2023

Abstract
Demineralized dentin matrix (DDM) is an osteoconductive and osteoinductive material, which was successfully performed in sinus floor augmentation and alveolar ridge augmentation in clinical application. It releases bone morphogenetic protein (BMP) and other growth factors which make DDM a suitable grafting material. However, the granular particle of DDM makes it difficult to anchor into the bone defect area. The aim of this study was to investigate biological effects as well as an osteoinductivity of the combination of DDM and Fibrin Glue (FG) at an optimal ratio on bone healing from critical bone defect in an animal model. Mouse osteoblastic cell line (MC3T3-E1) was co-cultured with various ratios of DDM and FG to examine their effects on osteoblast proliferation and differentiation indicated by alkaline phosphatase (ALP) activity, osteocalcin (OC) production and mineralized nodules formation. The optimal ratio was then chosen to further study with rabbit calvarial defective model which they were implanted with DDM or DDM-FG1 (1:0.1) and DDM-FG2 (1:0.5) compounds (w/v) or blank for 2, 4, 8 and 12weeks for investigating soft tissue and new bone regeneration. Micro-CT and histology analysis were used to evaluate the total grafting properties according to the different healing periods. The result from in vitro studies demonstrated that the ratio of 1:0.1 induced more ALP activity, mineralized nodules at the same time, 1: 0.5 (DDM-FG combined) induced more Osteocalcin (OC) at given days. In animal model, the 3D new bone volume in all DDM-FG treatment were significantly greater than blank group at 2, 4, 8 and 12 weeks. Furthermore, the new bone volume was greater in DDM-FG2 when compared to other groups at early week of the healing period. In histological analysis, numbers of osteoblasts were formed as a cluster adjacent to the DDM particles where we could observe a newly formed bone in all groups suggesting an osteoinductive property of DDM. Moreover, the greater new collagen synthesis observed at 4 weeks suggested that the early bone healing was induced in a group treated with DDM-FG2. This study demonstrates that at optimal ratio of DDM-FG compound enhances the osteogenic activities and bone regeneration.
Evaluating ChatGPT as an Adjunct for the Multidisciplinary Tumor Board Decision-Making in Primary Breast Cancer Cases
Authors: Lukac Stefan , Dayan Davut , Fink Visnja , Leinert Elena , Hartkopf Andreas , Veselinovic Kristina , Janni Wolfgang , Rack Brigitte , Pfister Kerstin , Heitmeir Benedikt , Ebner Florian 
Published: April 2023

Abstract
As the available information about breast cancer is growing every day, the decision-making process for the therapy is getting more complex. ChatGPT as a transformer-based language model possesses the ability to write scientific articles and pass medical exams. But is it able to support the multidisciplinary tumor board (MDT) in the planning of the therapy of patients with breast cancer?
We performed a pilot study on 10 consecutive cases of breast cancer patients discussed in MDT at our department in January 2023. Included were patients with a primary diagnosis of early breast cancer. The recommendation of MDT was compared with the recommendation of the ChatGPT for particular patients and the clinical score of the agreement was calculated.
Results showed that ChatGPT provided mostly general answers regarding chemotherapy, breast surgery, radiation therapy, chemotherapy, and antibody therapy. It was able to identify risk factors for hereditary breast cancer and point out the elderly patient indicated for chemotherapy to evaluate the cost/benefit effect. ChatGPT wrongly identified the patient with Her2 1+ and 2+ (FISH negative) as in need of therapy with trastuzumab and called endocrine therapy “hormonal treatment”.
Support of artificial intelligence by finding individualized and personalized therapy for our patients is unavoidable in this time of rapidly expanding amount of information. ChatGPT has the potential to find its spot in clinical medicine, but the current version is not able to provide specific recommendations for the therapy of patients with primary breast cancer.
Implementing Advance Care Planning in Palliative and End of Life Care: Perspectives from Community Nursing
Authors: Wilkin Katie , Fang Mei Lan , Sixsmith Judith 
Published: April 2023

Abstract
Background Advance care planning (ACP) is a priority topic within palliative care service provisions. Many healthcare professionals have a duty of care to engage patients in ACP discussions as early as possible. Family members of palliative patients are arguably best placed to encourage discussions of ACP, although often find this difficult. Therefore, community nurses immediately caring for these patients can encourage these discussions, utilising the built rapport and relationships they have with both patients and families. Despite this potential, nurses appear conflicted towards ACP discussions because of several barriers (e.g., education, time) or facilitators (e.g., relationships, patient readiness). This review was undertaken to explore these factors which influence how nurses apply ACP in the context of caring for their patients.Method To explore the perspectives of community nurses with ACP application, a scoping review was undertaken in June 2021 and the resultant database of 15 articles were thematically analysed to answer a research question: ‘What factors contribute to or hinder ACP discussion for community nurses, when providing care to palliative patients?’.Results Several ACP barriers and facilitators were identified from a nursing standpoint. Key barriers were – lack of confidence, competence, role, and prognostic uncertainty. Key facilitators identified the pertinence of the patient-practitioner relationship enabling ACP amongst nurses who had both competence and experience in ACP and/or palliative care.Conclusions This review suggests that community nurses’ perceived experience and competence is associated with implementing ACP effectively with palliative patients. Furthermore, it identified that future research is needed to develop interventions to promote ACP uptake in community settings, enabling confidence building and higher standards of palliative care via the implementation of ACPs.