bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pembuatan Aplikasi Peta Interaktif 3 Dimensi (Studi Kasus: Pondok Pesantren Al Munawwir Krapyak Yogyakarta)
Authors: Fahmi Afrizal Amri 
Published: May 2023

Pondok Pesantren Al Munawwir Krapyak Yogyakarta adalah lembaga pendidikan dan sosial keagaamaan yang berdiri sejak 15 November 1911 dengan luas area kurang lebih 5,876 hektar. Area Pondok Pesantren Al Munawwir tidak memiliki batas area pondok yang jelas sehingga kerap membuat pengunjung yang datang ke kompleks Pondok Pesantren Al Munawwir kesulitan dalam menemukan lokasi kompleks pondok pesantren. Oleh karena itu, perlu adanya informasi pondok pesantren secara visual seperti peta 3D yang interaktif yang dapat menunjukkan bangunan kompleks Pondok Pesantren Al Munawwir, agar dapat membantu mengatasi permasalahan tersebut. Penelitian ini dilakukan untuk membuat peta interaktif 3D untuk membantu mengatasi permasalahan tersebut.Pembuatan peta interaktif 3D ini menggunakan perangkat lunak yaitu unreal engine. Unreal engine merupakan sebuah game engine yang sedang berkembang dan banyak digunakan dalam pembuatan peta 3D maupun game (Epic Games, 2011). Perangkat lunak ini memiliki kemampuan untuk membuat lingkungan virtual yang sesuai dengan dunia nyata. Penggunaan unreal engine dipilih karena merupakan perangkat lunak yang bersifat open source sehingga bebas dikembangkan dengan mudah oleh siapapun.Hasil dari pembuatan aplikasi adalah aplikasi peta interaktif 3D Pondok Pesantren Al Munawwir. Pengujian aplikasi peta interaktif 3D dilakukan dengan pengujian fungsional dan non fungsional. Pengujian fungsional untuk mengetahui apakah aplikasi peta interaktif 3D dapat berjalan dengan baik sedangkan pengujian non fungsional untuk mengetahui spesifikasi untuk menjalankan aplikasi peta interaktif 3D. Hasil pengujian ini menunjukkan aplikasi peta interaktif 3D dapat berjalan dengan baik. Spesifikasi yang direkomendasikan untuk menajalankan aplikasi peta interaktif 3D ini yaitu Intel Core i5 8300H, Memory 8GB DDR4, NVIDIA GeForce GTX 1050 4GB.
Penggunaan Citra Landsat untuk Pendeteksian Anomali Suhu Permukaan Sebagai Indikasi Keberadaan Manifestasi Panas Bumi. Studi Kasus: Sipoholon, Indonesia
Authors: Mardiati, S.T., M.Eng. Dani 
Published: May 2023

Sipoholon merupakan sebuah kecamatan yang terletak di Kabupaten Tapanuli Utara, Sumatera Utara yang dilewati oleh Sistem Sesar Sumatera. Berdasarkan peta Geologi Lembar Sidikalang, ditemukan adanya manifestasi panas bumi berupa mata air panas (hot spring) di daerah tersebut. Keberadaan manifestasi ini menunjukkan adanya sistem panas bumi yang bekerja di bawahnya. Keberadaan manifestasi panas bumi di suatu daerah akan berpengaruh terhadap suhu permukaan tanah di daerah tersebut. Pendeteksian anomali suhu permukaan tanah dapat dilakukan dengan berbagai cara. Salah satu metode yang mudah untuk dilakukan yaitu menggunakan Citra Penginderaan Jauh. Citra Landsat merupakan salah satu citra penginderaan jauh yang dapat digunakan untuk mendeteksi anomali suhu permukaan. Penelitian ini bertujuan untuk mendeteksi anomali suhu permukaan sebagai indikasi adanya manifestasi panas bumi di Sipoholon, Sumatera Utara menggunakan Citra Landsat. Band 10 dan band 11 yang merupakan thermal infrared (TIR) diolah untuk mendapatkan suhu kecerahan (brightness temperature). Band 4 dan 5 digunakan untuk menghitung kerapatan vegetasi (NDVI) dan emisivitas suhu permukaan. Gabungan dari band 10, band 11 dan NDVI digunakan untuk menghitung nilai suhu permukaan tanah (Land Surface Temperature). Data lapangan berupa suhu mata air panas dan suhu permukaan tanah diambil untuk melakukan verifikasi terhadap analisis citra yang telah dilakukan. Hasil analisis citra menunjukkan bahwa suhu permukaan di lokasi penelitian berkisar antara 16,7°C sampai dengan 28,4°C. Anomali suhu tinggi berada di daerah yang dilewati oleh sesar sumatera. Hasil verifikasi di lapangan menunjukkan hasil yang selaras, terdapat mata air panas di daerah yang dilewati oleh sesar sumatera dengan suhu 35,7 °C – 64,4°C. Sedangkan suhu permukaan tanah berkisar antara 31,3°C – 48,7°C. Hal ini menunjukkan bahwa citra landsat berupa suhu permukaan tanah (LST) dapat digunakan untuk mendeteksi anomali suhu permukaan sebagai indikasi adanya sistem panas bumi di suatu daerah untuk memudahkan pengerucutan lokasi pada tahap eksplorasi.
Weiner Topological Index for Neutrosophic Graph based on Strong Domination Set and Number
Authors: Zandi Amir_majeed , Nabeel Ezzulddin Arif2  
Published: May 2023

Different topological indices will always be valuable in a variety of disciplines, including chemistry, economics, electronics, business studies, social sciences and medicine. According to the dominating set and number, the Wiener index for neutrosophic graphs (NG) will be studied in considerable detail in this research.
Additionally, the Average Wiener index for an NG has been defined, and several associated theorems have been introduced.
Delayed fatal intracranial hemorrhage in a pediatric patient following resection and adjuvant cranial radiotherapy for ependymoma: illustrative case
Authors: Farmer Matthew L. , Conley Adam M. , Dilustro Joseph F. 
Published: May 2023

BACKGROUND
Cranial radiotherapy (CRT) is an important treatment modality for malignancies of the central nervous system. CRT has deleterious effects that are commonly classified into acute, early delayed, and late delayed. Late-delayed effects include weakening of the cerebral vasculature and the development of structurally abnormal vasculature, potentially leading to ischemic or hemorrhagic events within the brain parenchyma. Such events are not well reported in the pediatric population.

OBSERVATIONS
The authors present the case of a 14-year-old patient 8.2 years after CRT who experienced intracerebral hemorrhage. Autopsy demonstrated minimal pathological change without evidence of vascular malformation or aneurysm. These findings were unexpected given the degree of hemorrhage in this case. However, in the absence of other etiologies, it was believed that late-delayed radiation effect was the cause of this patient’s fatal hemorrhage.

LESSONS
Although not all cases of pediatric spontaneous intracerebral hemorrhage will have a determined etiology, the authors’ patient’s previous CRT may represent a poorly defined risk for late-delayed hemorrhage. This correlation has not been previously reported and should be considered in pediatric patients presenting with spontaneous hemorrhage in a delayed fashion after CRT. Neurosurgeons must not be dismissive of unexpected events in the remote postoperative period.
Trigeminal neuralgia secondary to vascular compression and neurocysticercosis: illustrative case
Authors: Vásquez Mao , Saavedra Luis J. , García Hector H. , Vela Evelyn , Medina Jorge E. , Lozano Miguel , Hoyos Carlos , Lines-Aguilar William W. 
Published: May 2023

BACKGROUND
Trigeminal neuralgia (TN) is a frequent neurosurgical problem negatively influencing the quality of life of patients. The standard surgical treatment is microvascular decompression for primary cases and decompression of the mass effect, mainly tumors, for secondary cases. Neurocysticercosis (NCC) in the cerebellopontine angle is a rare etiology of TN. The authors report a case in which NCC cysts around the trigeminal nerve coexisted with a vascular loop, which compressed the exit of the trigeminal nerve from the pons.

OBSERVATIONS
A 78-year-old woman presented with a 3-year history of persistent severe pain in the left side of her face, refractory to medical treatment. On gadolinium-enhanced magnetic resonance imaging, cystic lesions were observed around the left trigeminal nerve and a vascular loop was also present and in contact with the nerve. A retrosigmoid approach for cyst excision plus microvascular decompression of the trigeminal nerve was successfully performed. There were no complications. The patient was discharged without facial pain.

LESSONS
Albeit rare, TN secondary to NCC cysts should be considered in the differential diagnosis in NCC-endemic regions. In this case, the cause of the neuralgia was probably both problems, because when both were treated, the patient improved.
Endovascular treatment of a ruptured pure arterial malformation and associated dysplastic middle cerebral artery dissecting aneurysm: illustrative case
Authors: Marlow Christine , Cuoco Joshua A. , Ravina Kristine , Sloboda Cole A. , Entwistle John J. 
Published: May 2023

BACKGROUND
Pure arterial malformations are characterized as unique cerebrovascular lesions with a dilated, coil-like appearance and tortuous arteries without early venous drainage. Historically, these lesions have been described as incidental findings with a benign natural history. However, pure arterial malformations can rarely demonstrate radiographic progression and develop associated focal aneurysms with an unclear risk of rupture. Whether radiographic progression of these lesions or the presence of an associated aneurysm warrants treatment remains controversial.

OBSERVATIONS
A 58-year-old male presented with sudden-onset left hemiparesis. Computed tomography revealed a large, acute, right frontotemporoparietal intraparenchymal hemorrhage with underlying irregular curvilinear calcifications. Diagnostic cerebral angiography revealed a dysplastic right middle cerebral artery dissecting aneurysm along the M2 segment associated with a pure arterial malformation, which was treated with endovascular flow diversion in a delayed fashion.

LESSONS
Pure arterial malformations with associated focal aneurysms may not exhibit a benign natural history as once thought. Intervention should be considered for ruptured pure arterial malformations to mitigate the risk of rerupture. Asymptomatic patients with a pure arterial malformation with an associated aneurysm should at least be followed closely with interval radiographic imaging to evaluate for malformation progression or changes in aneurysmal morphology.
Etiology of spastic foot drop among 16 patients undergoing electrodiagnostic studies: patient series
Authors: Shields Lisa B. E. , Iyer Vasudeva G. , Zhang Yi Ping , Shields Christopher B. 
Published: May 2023

BACKGROUND
Differentiating foot drop due to upper motor neuron (UMN) lesions from that due to lower motor neuron lesions is crucial to avoid unnecessary surgery or surgery at the wrong location. Electrodiagnostic (EDX) studies are useful in evaluating patients with spastic foot drop (SFD).

OBSERVATIONS
Among 16 patients with SFD, the cause was cervical myelopathy in 5 patients (31%), cerebrovascular accident in 3 (18%), hereditary spastic paraplegia in 2 (12%), multiple sclerosis in 2 (12%), chronic cerebral small vessel disease in 2 (12%), intracranial meningioma in 1 (6%), and diffuse brain injury in 1 (6%). Twelve patients (75%) had weakness of a single leg, whereas 2 others (12%) had bilateral weakness. Eleven patients (69%) had difficulty walking. The deep tendon reflexes of the legs were hyperactive in 15 patients (94%), with an extensor plantar response in 9 patients (56%). Twelve patients (75%) had normal motor and sensory conduction, 11 of whom had no denervation changes of the legs.

LESSONS
This study is intended to raise awareness among surgeons about the clinical features of SFD. EDX studies are valuable in ruling out peripheral causes of foot drop, which encourages diagnostic investigation into a UMN source for the foot drop.
Ondine’s curse: clinical presentation with diaphragmatic pacing and spontaneous respiratory recovery. Illustrative case
Authors: Schupper Alexander J. , Devarajan Alex , Lee Dong-Seok , Perez Enrique , Shrivastava Raj K. 
Published: May 2023

BACKGROUND
The complexity of posterior fossa surgery can often lead to rare complications due to the anatomy involved. Vestibular schwannoma resection is a common pathology in the posterior fossa, often requiring surgical intervention. Given the proximity of this space to the brainstem, cranial nerve VII/VIII complex, and posterior inferior cerebellar artery (PICA), neurovascular complications are not infrequent. A rare vascular complication from this surgical approach is a lateral medullary infarction from injury to the lateral medullary segment of the proximal PICA, leading to central hypoventilation syndrome (CHS).

OBSERVATIONS
This report presents a unique case of a 51-year-old man who underwent a retrosigmoid craniectomy for resection of a vestibular schwannoma. Following surgery, the patient was unable to be weaned off the ventilator and was noted to become apneic while he slept, a clinical picture consistent with Ondine’s curse.

LESSONS
This report discusses the anatomical considerations of this surgical corridor leading to this complication and the management of a patient with acquired Ondine’s curse and reviews the scarce literature on this uncommon cause of acquired CHS.
ROLE OF RADIOGRAPHIC EVALUATION IN TREATMENT PLANNING FOR PATIENTS WITH MISSING UPPER LATERAL INCISORS
Authors: Korobov P.S. , Kuroedova V.D. , Vyzhenko Ye.Ye. 
Published: May 2023

One of the dental conditions, which require a complex approach to diagnosis and treatment, is adentia of permanent upper lateral incisors that significantly affects the appearance of an individual regardless of gender.
The purpose of the study is to identify the prevalence of adentia of permanent upper lateral incisors and to evaluate the accompanying factors that influence the choice of treatment strategy.
A total of 1007 orthopantomograms of patients with malocclusions were analyzed, and 42 patients aged 5–20 years who had no permanent upper lateral incisors were selected. The following factors were taken into account: gender, age, type of adentia, space in the place of missing incisors, presence of rudimentary and supernumerary teeth, other missing teeth, and the presence of the third upper and lower molars, location of permanent canines and their rudiments.
The results of our study demonstrate the prevalence of adentia of permanent upper lateral incisors is 4.17%. Symmetrical or bilateral adentia of lateral incisors is more common and detected in 64.3% of the patients. The presence of space in the dentition in the area of ​​missing upper lateral incisors is found in 64.3% of patients.
Thus, in the presence of preserved temporary lateral incisors, diastemas, additional dentitions that contribute to orthodontic correction in creating a full-fledged place for the restoration of the tooth row defect in the area of ​​the lateral incisors, the replacement of missing teeth by implant placement or the replacement of the defect with non-removable aesthetic orthopaedic structures is recommended. If there is no free space in the dentition due to the displacement of the canines towards the direction of the defect, the transformation of the crown part of the canines by applying restoration technique can be recommended. Determining the peculiarities of treatment planning for adentia of the lateral incisors, taking into account the occlusal relations, seems to be promising task for further research.
EFFECT OF ORTHODONTIC TREATMENT OF GENERALIZED PERIODONTITIS ON ORAL HYGIENIC STATUS
Authors: Batig I.V. , Borysenko A.V. 
Published: May 2023

Orthodontic treatment of patients with generalised periodontitis can have a negative impact on the periodontium. Removable orthodontic appliances have a lesser impact on the periodontium. Considering such details of orthodontic treatment for patients with generalized periodontitis, it is critical to start orthodontic treatment as early as possible, when significant manifestations of traumatic occlusion and pronounced displacements of teeth have not developed yet.
The study aimed to determine the effectiveness of early orthodontic treatment using removable orthodontic appliances in patients with generalized periodontitis and its effect on the hygienic status of the periodontium. The study involved 40 adolescents (18-35 years) with generalized periodontitis who had displaced upper front teeth. Removable orthodontic appliances and individual retainers were used for orthodontic correction, and the patients underwent a comprehensive examination of the periodontium to assess their hygienic indices during the course of treatment.
The assessment of the periodontal tissues shows that almost all patients had an inflammatory process in their periodontal tissues. Previously, the patients had undergone Phase 1 integrated treatment for generalized periodontitis. One month after the beginning of the orthodontic correction, there was certain deterioration in the periodontal condition. However, following the completion of orthodontic treatment, the hygienic condition of the periodontium improved.
The study concluded that the combination of periodontal disease and tooth displacement requires comprehensive treatment using orthodontic methods. While the use of orthodontic treatment led to some deterioration in the periodontal condition, appropriate correction of drug treatment and rational oral hygiene practices can compensate for this.
APP/PS1 Gene-Environmental Cadmium Interaction Aggravates the Progression of Alzheimer’s Disease in Mice via the Blood-Brain Barrier, Amyloid-β, and Inflammation
Authors: Liu Jieyi , Xie Yirong , Lu Yao , Zhao Zhiqiang , Zhuang Zhixiong , Yang Linqing , Huang Haiyan , Li Hongya , Mao Zhiyi , Pi Shurong , Chen Fubin , He Yun 
Published: May 2023

Background: There is limited information about gene-environment interaction on the occurrence and the progression of Alzheimer’s disease. Objective: To explore the effect of environmental low-dose cadmium (Cd) exposure on the progress of Alzheimer’s disease and the underlining mechanism. Methods: We administered 1 mg/L, 10 mg/L cadmium chloride (treated groups), and water (control group) to C57BL/6J and APP/PS1 mice through drinking water, from one week before mating, until the offspring were sacrificed at 6 months of age. The behaviors, Cd level, blood-brain barrier (BBB) leakage, Aβ1-42 deposition, and inflammation expression were evaluated in these mice. Results: Mice of both genotypes had similar blood Cd levels after exposure to the same dose of Cd. The toxic effects of Cd on the two genotypes differed little in terms of neuronal histomorphology and BBB permeability. Cd caused a series of pathological morphological changes in the mouse brains and more fluorescent dye leakage at higher doses. Furthermore, the APP/PS1 mice had more severe damage than the C57BL/6J mice, based on the following five criteria. They were increasing anxiety-like behavior and chaos movement, spatial reference memory damage, Aβ plaque deposition in mouse brains, increasing microglia expression in the brain, and IL-6 higher expression in the cortex and in the serum. Conclusion: Low-dose Cd exposure for 6 months increases Aβ plaque deposition and BBB permeability, exacerbates inflammatory responses, and activates microglia, in APP/PS1 mice. APP/PS1 gene-environmental Cd interaction aggravates the progression of Alzheimer’s disease in mice.
Concomitant Neuronal Tau Deposition and FKBP52 Decrease Is an Early Feature of Different Human and Experimental Tauopathies
Authors: Meduri Geri , Guillemeau Kevin , Daguinot Corentin , Dounane Omar , Genet Melanie , Ferrara Luigi , Chambraud Beatrice , Baulieu Etienne Emile , Giustiniani Julien 
Published: May 2023

Background: Pathological tau proteins constitute neurofibrillary tangles that accumulate in tauopathies including Alzheimer’s disease (AD), progressive supranuclear palsy (PSP), and familial frontotemporal lobar degeneration (FTLD-Tau). We previously showed that the FKBP52 immunophilin interacts functionally with tau and strongly decreases in AD brain neurons in correlation with tau deposition. We also reported that FKBP52 co-localizes with autophagy-lysosomal markers and an early pathological tau isoform in AD neurons, suggesting its involvement in autophagic tau clearance. Objective: Our objective was to evaluate if differences in neuronal FKBP52 expression levels and subcellular localization might be detected in AD, PSP, familial FTLD-Tau, and in the hTau-P301 S mouse model compared to controls. Methods: Cell by cell immunohistofluorescence analyses and quantification of FKBP52 were performed on postmortem brain samples of some human tauopathies and on hTau-P301 S mice spinal cords. Results: We describe a similar FKBP52 decrease and its localization with early pathological tau forms in the neuronal autophagy-lysosomal pathway in various tauopathies and hTau-P301 S mice. We find that FKBP52 decreases early during the pathologic process as it occurs in rare neurons with tau deposits in the marginally affected frontal cortex region of AD Braak IV brains and in the spinal cord of symptomless 1-month-old hTau-P301 S mice. Conclusion: As FKBP52 plays a significant role in cellular signaling and conceivably in tau clearance, our data support the idea that the prevention of FKBP52 decrease or the restoration of its normal expression at early pathologic stages might represent a new potential therapeutic approach in tauopathies including AD, familial FTLD-Tau, and PSP.
Chiral Amino Acid Profiling in Serum Reveals Potential Biomarkers for Alzheimer’s Disease
Authors: Liu Mingxia , Li Mo , He Jing , He Yi , Yang Jian , Sun Zuoli 
Published: May 2023

Background: Alzheimer’s disease (AD) is a complex neurodegenerative disease, and increasing evidence has linked dysregulation of amino acids to AD pathogenesis. However, the existing studies often ignore the chirality of amino acids, and some results are inconsistent and controversial. The changes of amino acid profiles in AD from the perspective of enantiomers remain elusive. Objective: The purpose of this study is to investigate whether the levels of amino acids, especially D-amino acids, are deregulated in the peripheral serum of AD patients, with the ultimate goal of discovering novel biomarkers for AD. Methods: The chiral amino acid profiles were determined by HPLC-MS/MS with a pre-column derivatization method. Experimental data obtained from 37 AD patients and 34 healthy controls (HC) were statistically analyzed. Results: Among the 35 amino acids detected, D-proline, D/total-proline ratio, D-aspartate, and D/total-aspartate ratio were decreased, while D-phenylalanine was elevated in AD compared to HC. Significant age-dependent increases in D-proline, D/total-proline ratio, and D-phenylalanine were observed in HC, but not in AD. Receiver operator characteristic analyses of the combination of D-proline, D-aspartate, D-phenylalanine, and age for discriminating AD from HC provided satisfactory area under the curve (0.87), specificity (97.0%), and sensitivity (83.8%). Furthermore, the D-aspartate level was significantly decreased with the progression of AD, as assessed by the Clinical Dementia Rating Scale and Mini-Mental State Examination. Conclusion: The panels of D-proline, D-phenylalanine, and D-aspartate in peripheral serum may serve as novel biomarker candidates for AD. The latter parameter is further associated with the severity of AD.