bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Novel Computer Modeling and Simulation Technique for Bronchi Motion Tracking in Human Lungs under Respiration
Authors: kim byeong-jun , Ahn Hyo Yeong , Song Chanhee , Ryu Dongman , Goh Tae Sik , Lee Jung Sub , Lee Chiseung 
Published: April 2023

Abstract
In this work, we proposed a novel computer modeling and simulation (CM&S) technique for motion tracking of lung bronchi (or tumors) under respiration using 9 cases of computed tomography (CT)-based patient-specific finite element (FE) models and the Ogden’s hyperelastic constitutive model. In the fabrication of patient-specific FE models for respiratory system, various organs such as mediastinum, diaphragm, and thorax that could affect the lung motions during breathing were considered. In order to describe the nonlinear material/mechanical behavior of human lung tissue (lung parenchyma), the comparative simulation for biaxial tension-compression of lung tissue were carried out using several hyperelastic models, and then, the Ogden’s model was adopted to as the optimal model. Based on the aforementioned FE models and Ogden’s material model, the 9 cases of respiration simulation were carried out from exhalation to inhalation, and the motion of lung bronchi (or tumors) was tracked. In addition, the changes of lung volume, lung cross-sectional area on the axial plane during breathing were calculated. Finally, the simulation results were quantitatively compared to the inhalation/exhalation CT images of 9 objects to validate the proposed technique. The relative errors of the simulation to the clinical data are able to predict the lung lesion motion with an average landmark error: anterior/posterior, 2.67%; right/left, 2.10%; and superior/inferior direction 1.10% error and confirmed to be well matched within the range of 0.20–5.00% of the total average relative error in the lung superior-inferior cross-sectional area. Additionally, the range of volume error was within 1.29–9.23%.
Phosphaturic mesenchymal tumor of nose: a case report
Authors: Singhal Surinder K , Gupta Nitin 
Published: April 2023

Abstract
Background: To report a case of phosphaturic mesenchymal tumour of nose highlighting the diagnostic challenges involved.
Case presentation:
A 50 years old male who had history of multiple lower limb fractures presented with epistaxis and a vascular mass in left nasal cavity that enhanced on contrast-enhanced computed tomography (CECT), and MRI. The patient had raised serum phosphate and PTH levels. The tumour was excised endoscopically and the patient recovered completely.
Conclusion:Malignant Phosphaturic mesenchymal tumors (PMTs), although rare, may behave aggressively, recur and metastasize. They are difficult to diagnose and should be kept in differential diagnosis of nasal tumours who present with osteomalacia.
A remote-sensing assessment of oak forest recovery after postfire restoration
Authors: Lopes Luis Filipe , Dias Filipe S. , Fernandes Paulo M. , Acácio Vanda 
Published: April 2023

Abstract
Background: Mediterranean Europe is witnessing an increase in extreme wildfire events, which has led to increasing socioeconomic and ecological impacts. Postfire restoration emerges as an important tool for impact mitigation and ecosystem recovery. However, there is a large knowledge gap on the ecological effects of such interventions. We used remote sensing to assess the impacts of postfire restoration on the recovery of deciduous oak forests in Portugal, based on a total of 3013 sampling points in areas with and without postfire intervention. We quantified the vegetation index NDVI as a proxy of oak forest recovery for a period of 4 years after the fire, for fire events that occurred in 2016 and 2017. Temporal changes in NDVI were modelled with a Generalized Additive Mixed Model (GAMM), as a function of postfire restoration, fire characteristics (burn severity, number of fires, and time since fire), topography (aspect, elevation, and slope) and postfire drought events (PDSI).Results: The fitted model accounted for 26.4% of NDVI variance. The model showed a significant positive effect of postfire restoration on NDVI recovery over time, although with a minor effect; it also showed a negative effect of severe drought and a positive effect of severe wetness on NDVI recovery. Regarding fire characteristics, low and high burn severities showed a positive effect on recovery, while moderate burn severity levels showed a null effect. Number of fires showed an increasingly negative effect on recovery, until a maximum of 6 fires.Conclusions: Oak forest recovery was positively affected by postfire restoration, although this effect was small and likely limited by lack of available data. On the contrary, oak forest recovery was negatively affected by increased drought severity but its relation with fire characteristics varied with thresholds of burn severity levels and number of fires. Our study highlights the importance of monitoring the effects of postfire restoration on forest recovery, in order to improve knowledge on postfire forest management and species adaptation. This becomes even more relevant under forecasted scenarios of increased wildfire frequency and severity interacting with other climate-driven disturbances, which will further impact the capacity of forest recovery in the future.
Effect of Instrument-Assisted Soft Tissue Mobilizatio combined with blood flow restriction training on function, pain and strength of patients with patellofemoral joint pain
Authors: liu yang , wu lianqing 
Published: April 2023

Abstract
Background: Patellofemoral pain syndrome is a prevalent sports injury that affects athletes both in their daily lives and during training. This condition causes pain in the area where the kneecap and thigh bone meet, and it can be quite debilitating. Whether an athlete is simply going about their day or pushing themselves to the limit during a workout, patellofemoral pain can be a significant hindrance.
Purpose: The purpose of this study is to investigate the impact of combining Instrument-Assisted Soft Tissue Mobilization (IASTM) treatment with blood flow restriction training on individuals with patellofemoral pain. Specifically, the study will assess improvements in pain levels, functional ability, strength, and joint mobility resulting from this treatment approach.
Methods: Twenty-six patients diagnosed with patellofemoral pain were selected as observation subjects and randomly divided into two groups: the IASTM combined with blood flow restriction training treatment group (n=13) and the IASTM treatment group alone (n=13). The treatment period was 4 weeks. In this study, we conducted a comparison and analysis of the knee's visual analogue pain scale (VAS), Lysholm score, and a modified version of the Thomas test (MTT) at three different time points.In this subject paper, we compared and analyzed the VAS score of the knee, Lysholm score of the knee, and MTT at three different time points - before treatment, immediately after the first treatment, and after four weeks of treatment. Additionally, we recorded data using a maximum isometric muscle strength testing system for the lower extremity extensors four weeks before and after treatment.
Results: In the intra-group comparison of Lysholm score, after the first treatment and 4 weeks of treatment, the scores of the two groups were significantly different from those before treatment (P<0.05), and the VAS scores after the first treatment and 4 weeks of treatment were significantly different from those before treatment (P<0.05), and the pain was significantly improved. After 4 weeks of treatment, the strength of the extensor muscle of the lower extremity was significantly improved (P<0.001), but there was no significant change in the strength test between groups (P>0.05). After MTT test, there were significant changes in the three joint angles before and after treatment (P>0.05).
Conclusion: The combination of IASTM treatment and blood flow restriction has been shown to significantly reduce pain and improve periprosthetic soft tissue flexibility. Additionally, IASTM treatment alone was found to be more effective in improving knee pain and muscle flexibility, ultimately leading to increased knee strength in a pain-free state.In terms of the overall treatment outcome, it was found that the combined treatment was significantly more effective than the adjuvant soft tissue release treatment alone.
Forecast of Electricity Production from Coal and Renewable Sources in Major European Economies
Authors: TULKINOV SHAVKATJON 
Published: April 2023

Abstract

Purpose – The importance of electricity in the economic development of nations is undeniable. Although coal and renewable sources are significant contributors to electricity production in major world economies, a new study seeks to predict the future production of electricity from these sources in Germany, the United Kingdom, and France.
Design/methodology/approach – Two optimized grey forecasting models – DGM (1,1,α) and EGM (1,1,θ,α) – are used to forecast electricity production. Also, the accuracy of the forecasts is measured through the Javed-Cudjoe scale of Mean Absolute Percentage Error (MAPE).
Findings – The electricity production from coal is on the decline, while renewable energy production is increasing in Germany, the United Kingdom, and France. The accuracy of the forecasts for these trends, as generated by two grey models, surpasses that of the Exponential Triple Smoothing (ETS).
Originality/value – For the first time, optimized even and discrete grey forecasting models have been utilized to make predictions about electricity production in the three largest economies in Europe.
Soft computing in secure social internet of things based on post-quantum blockchain with federated learning
Authors: BISHNOI AMIT KUMAR , parikh Swapnil , Kumari Alka , Kumar Avadhesh , Sharma Meenakshi , Ganesan Geetha 
Published: April 2023

Abstract
A system's compliance with a specified security model, security standard, or specification is the focus of a security evaluation. The process of selecting the appropriate model for security assessment is determined by the type of cryptosystem. There are various models available. By enhancing data authentication and security for soft computing, this study proposes a novel technique for secure social internet of things (SSIoT) privacy analytics using post-quantum blockchain federated learning with encryption and trust analysis, the privacy analysis and data authentication. In terms of latency, QoS, energy consumption, packet loss rate, and other parameters, the experimental analysis is carried out. The purpose of the security analysis and performance evaluations is to demonstrate that the proposed scheme can satisfy the security requirements and enhance the FL model's performance. Federated learning is able to carry out effective machine learning (ML) with multiple participants while maintaining privacy of terminal personal data. Our proposed combination of federated learning as well as blockchain provides a solid foundation for future industrial Internet, as demonstrated by the numerical results.the proposed technique attainedenergy consumption of 55%, packet loss rate of 59%, QoS of 79%, Latency of 72%, network security analysis of 82%.
An omics strategy increasingly improves the discovery of genetic loci and genes for seed-coat color formation in soybean
Authors: song jian , Xu Ruixin , Guo Qingyuan , Wu Caiyu , Li Yinghui , Wang Xuewen , Wang Jun , Qiu Lijuan 
Published: April 2023

Abstract
The phenotypic color of seeds is a complex agronomic trait and has economic and biological significance. The genetic control and molecular regulation mechanisms have been extensively studied. Here, we used a multi-omics strategy to explore the color formation in soybean seeds at a big-data scale. We identified 13 large quantitative trait loci (QTL) for color with bulk segregating analysis in recombinant inbreeding lines. GWAS analysis of colors and decomposed attributes in 763 germplasms revealed associated SNP sites perfectly falling in five major QTL, suggesting inherited genetic control on color during natural selection. Further transcriptomics analysis before and after color accumulation revealed 182 differentially expression genes (DEGs) in the five QTL, including known genes CHS, MYB, and F3’H involved in pigment accumulation. More DEGs with consistently up- or down-regulation were identified as shared regulatory genes for two or more color formations while some DEGs were only for a specific color formation. For example, five up-regulated DEGs in QTL qSC-3 were in flavonoid biosynthesis responsible for black and brown seed. The DEG (Glyma.08G085400) was identified in the purple seed only, which encodes gibberellin 2-beta-dioxygenase in the metabolism of colorful terpenoids. The candidate genes are involved in flavonoid biosynthesis, transcription factor regulation, gibberellin and terpenoid metabolism, photosynthesis, ascorbate and aldarate metabolism, and lipid metabolism. Seven differentially expressed transcription factors were also found to regulate color formation, including a known MYB. The finds expand QTL and gene candidates for color formation, which could guide to breed better cultivars with designed colors.
Soil Nitrogen Cycling Following Invasive Shrub Removal
Authors: Moore Eric R. , Pouyat Richard V. , Trammell Tara L. E. 
Published: April 2023

Abstract
Invasive plants often alter ecosystem functions and processes, especially soil N cycling. In urban or recently disturbed forest stands, soil N is often more available and may facilitate plant invasion, which in turn increases N mineralization and available N. In eastern United States forests, the shrub Rosa multiflora (“rose”) is the dominant invader, yet potential effects on N cycling are poorly understood. Moreover, invasive plant management can impact soil N cycling by decreasing plant N uptake and disturbing the soil. The objectives of this study were to evaluate N cycling along a gradient of rose invasion and investigate potential changes to N cycling under four different management strategies: 1) do nothing (i.e., the control), 2) invasive plant removal, 3) removal followed by native seed mix addition, 4) removal, native seed mix, and chipped woody stem addition. We selected three forest sites experiencing a low, medium, or high amount of shrub invasion, and measured N cycling in the early (June) and late (September) growing seasons. We found N was immobilized in June and mineralized in September. One year after experimental management strategies were implemented, removal alone had no effect on N cycling compared to control plots, but addition of native seed mix and chipped stems reduced early-season nitrification in our medium invasion site. Our findings suggest that initial N cycling under different amounts of rose invasion and subsequent responses to management are complex, and that N cycling responds differentially to management in the year following invasive plant removal.
Adult stem cell activity in naked mole rats for long-term tissue maintenance
Authors: Montazid Shamir , Hart Daniel , Bandyopadhyay Sheila , Johnson Brian , Thrumurthy Sri , Gao Nan , Bansal Mukesh , Altrock Philipp , Rost Fabian , Penn Dustin , Wernisch Bettina , Gazinska Patrycja , Ziółkowski Piotr , Hayee Bu'Hussain , Tessitore Annamaria , Bodmer Walter , East James , Bennett Nigel , Tomlinson Ian , Irshad Shazia 
Published: April 2023

Abstract
The naked mole rat (NMR), Heterocephalus glaber, the longest-living rodent1, provides a unique opportunity to explore how evolution has shaped adult stem cell (ASC) activity with increasing lifespan. Using cumulative BrdU labelling and a quantitative imaging approach to track intestinal ASCs (Lgr5+) in NMRs over time in their native in vivo state, we show adaptations to living in near-anaerobic2, food-deprived3 subterranean environment, has necessitated an expanded pool of Lgr5+ cells, which exhibit slower division rates compared to short-lived mice, but have similar turnover as humans. Unlike human LGR5+ cells at the crypt base (LGR5+CBC) that slow down their division rates by entering quiescence(G0) 4, NMR Lgr5+CBC cells in both the small intestine and the colon transit slowly through the active cell cycle (G1 to M) by prolonging arrest at G1 and/or G2. The inverse correlation between ASC division rates and lifespan appears to be specific to Lgr5+CBC/LGR5+CBC cells as this relationship is not seen for cells outside the crypt base. Our data provide an explanation for the observed anticorrelation between somatic mutation rates and longevity in mammals5, with ASC lineages in longer-lived organisms turning over slowly to possibly mitigate ASC exhaustion and reduce mutation rates for long-term tissue maintenance. Finally, we also observe an expanded pool of differentiated cells in NMRs that confer enhanced protection and function to the intestinal mucosa which is able to detect any chemical imbalance in the luminal environment efficiently, triggering a robust anti-proliferative, pro-apoptotic response within the stem cell zone.
Molecular characterization of cowpea [Vigna unguiculata (L.) Walp.] subspecies with SSR markers
Authors: Quenum Allonoumi J. C. , Pasquet Remy S. , Bodian Amy , Fonceka Daniel , Djiboune Yvette R. , Cisse Ndiaga , Mbaye Mame S. , Diouf Diaga 
Published: April 2023

Abstract

Background Cowpea, Vigna unguiculata, is an important food legume in the tropics and subtropics. However, cowpea is a complex species with more than 10 subspecies which can hybridize and produce intermediate progenies. Partly because of the complex organization of the cowpea gene pool and the lack of adequate markers for these infraspecific units, cowpea breeders are not using the wild part of the cowpea gene pool.
Methods Here, we report the molecular characterization of 34 representative accessions with 61 SSR markers from coding regions.
Results If SSR failed to separate the closest groups, i.e. subsp. alba, subsp. tenuis and the perennial groups from subsp. unguiculata, a combination of few SSR markers can properly identify the main cowpea subspecies. Regarding the infraspecific phylogeny of cowpea, SSR markers confirm the special status of the annual subsp. unguiculata versus the different perennial subspecies. It confirms that subsp. protracta looks like the oldest subspecies, making the origin of the species in southern Africa likely. However, it unites in a single group, clearly separated from subsp. unguiculata, all the taxa of hybrid origin, i.e. subsp. alba, subsp. tenuis, subsp. pubescens and the BWA group of subsp. unguiculata.
Conclusion Although a limited number of markers was tested considering that several hundred of cowpea SSR are available, the present work shows that SSR markers can be used for molecular characterization of cowpea subspecies and can be very helpful for understanding its complex evolutionnary history.
Evaluation of a Carepartner-Integrated Telehealth Gait Rehabilitation Program for Persons with Stroke : Study Protocol for a Feasibility Study
Authors: Blanton Sarah , Cotsonis George , Brenan Kayla , Song Robert , Zajac-Cox Laura , Caston Sarah , Stewart Heather , Jayaraman Arun , Reisman Darcy , Clark Patricia C , Kesar Trisha 
Published: April 2023

Abstract
Background: Despite family carepartners of individuals post-stroke experiencing high levels of strain and reduced quality of life, stroke rehabilitation interventions rarely address carepartner well-being or offer training to support their engagement in therapeutic activities. Our group has developed creative intervention approaches to support families during stroke recovery, thereby improving physical and psychosocial outcomes for both carepartners and stroke survivors. The purpose of this preliminary clinical trial is to test the feasibility of an adapted, home-based intervention (Carepartner Collaborative Integrative Therapy for Gait-CARE-CITE-Gait) designed to facilitate positive carepartner involvement during home-based training targeting gait and mobility.
Methods: This two-phased study will determine the feasibility of CARE-CITE-Gait, a novel intervention developed by our team that leverages principles from our previous carepartner-focused upper extremity intervention. During the 4-week CARE-CITE-Gait intervention, carepartners review online video-based modules designed to illustrate strategies for an autonomy-supportive environment during functional mobility task practice, and the study team completes two 2-hour (home-based) visits for dyad collaborative goal setting. In Phase I, the usability and acceptability of the CARE-CITE-Gait modules will be evaluated by stroke rehabilitation content experts and carepartners. In Phase II, feasibility (based on measures of recruitment, retention, and intervention adherence) will be measured. Preliminary effects of the CARE-CITE-Gait will be gathered using a single-group, evaluator blinded, quasi-experimental design with repeated measures (two baseline visits one week apart, post-test, and one-month follow-up) with 15 carepartner and stroke survivor dyads. Outcomes include psychosocial variables (strain, family conflict surrounding stroke recovery, autonomy support and life changes) collected from carepartners, and measures of functional mobility, gait speed, stepping activity, and health-related quality of life collected from stroke survivors.
Discussion: The findings of the feasibility testing and preliminary data on the effects of CARE-CITE-Gait will provide justification and information to guide a future definitive randomized clinical trial. The knowledge gained from this study will enhance our understanding of and aid the development of rehabilitation approaches that address both carepartner and stroke survivor needs during the stroke recovery process.
Trial Registration:ClinicalTrials.gov, NCT 05257928. Registered 25 February 2022, https://clinicaltrials.gov/ct2/show/NCT05257928
Longitudinal NGAL and Cystatin C plasma profiles present a high level of heterogeneity in a mixed ICU population
Authors: Jou-Valencia Daniela , Volbeda Meint , Zijlstra Jan G , Kootstra-Ros Jenny E , Moser Jill , Meurs Matijs van , Koeze Jaqueline 
Published: April 2023

Abstract
Background
NGAL and Cystatin C (CysC) as biomarkers for the early detection of AKI are subject to both pathophysiological, as well as patient related heterogeneity. The aim of this study was to investigate the timeline of plasma levels of NGAL and CysC during the first seven days of ICU admission in a mixed ICU population and to relate these to AKI severity during ICU stay. Via these means we aimed to bring clarity to the previously reported heterogeneity of these renal biomarkers.
Methods
Prospective Observation Cohort. Consecutive patients admitted to adult ICU at an academic hospital in the Netherlands between 18-02-2014 and 31-03-2014 were included. Urine output, serum creatinine, plasma NGAL and CysC were recorded during the first seven days of ICU admission. Biomarker expression was analyzed based on KDIGO score and time of AKI diagnosis.
Results
335 patients were included, 110 met KDIGO criteria for AKI. NGAL and CysC plasma levels were higher in AKI patients compared to non-AKI, high variability in individual values resulted in 56% of AKI patients having a false negative, and 32% of non-AKI patients having a false positive. Individual biomarker levels were variable, and no pattern based on KDIGO score was observed.
Conclusions
Plasma NGAL and CysC as biomarkers for the early AKI detection are subject to pathophysiological, and patient related heterogeneity. Further understanding of individual biomarker profiles may help in their application amongst mixed ICU populations.
Trial Registration
The need for informed consent was waived by the Institutional Ethical Review Board of the University Medical Center Groningen (METc 2013 − 174) by Prof. dr. W.A. Kamps on May 17th 2013.