bluuebunny/crossref_metadata_2025_split huggingface dataset:
Role of theEscherichia coliubiquinone-synthesizing UbiUVT pathway in adaptation to changing respiratory conditions
Authors: Rodrigo Arias-Cartin , Katayoun Kazemzadeh Ferizhendi , Emmanuel Séchet , Ludovic Pelosi , Corinne Loeuillet , Fabien Pierrel , Frédéric Barras , Emmanuelle Bouveret 
Published: March 2023

ABSTRACTIsoprenoid quinones are essential for cellular physiology. They act as electron and proton shuttles in respiratory chains and in various biological processes.Escherichia coliand many α, β, and γ proteobacteria possess two types of isoprenoid quinones: ubiquinone (UQ) is mainly used under aerobiosis, while (demethyl)menaquinones ((D)MK) are mostly used under anaerobiosis. Yet, we recently established the existence of an anaerobic O2- independent UQ biosynthesis pathway controlled byubiT, ubiU,andubiVgenes. Here, we characterize the regulation ofubiTUVgenes inE. coli.We show that the three genes are transcribed as two divergent operons that are both under the control of the O2sensing Fnr transcriptional regulator. Phenotypic analyses using amenAmutant devoid of (D)MK revealed that UbiUV-dependent UQ synthesis is essential for nitrate respiration and for uracil biosynthesis under anaerobiosis, while it contributes, though modestly, to bacterial multiplication in the mouse gut. Moreover, we showed by genetic study and18O2labelling that UbiUV contribute to hydroxylation of ubiquinone precursors through a unique O2- independent process. Last, we report a crucial role ofubiTin allowingE. colito shift efficiently from anaerobic to aerobic conditions. Overall, this study uncovers a new facet of the strategy used byE. colito adjust its metabolism upon changing O2levels and respiratory conditions. This work links respiratory mechanisms to phenotypic adaptation, a major driver in the capacity ofE. colito multiply in gut microbiota, and of facultative anaerobic pathogens to multiply in their host.ABSTRACT IMPORTANCEEnterobacteria multiplication in the gastrointestinal tract is linked to microaerobic respiration and associated to various inflammatory bowel diseases. Our study focuses on biosynthesis of ubiquinone (UQ), a key player in respiratory chains, under anaerobiosis. The importance of this study stems from the fact that UQ usage was for long considered to be restricted to aerobic conditions. Here we investigated the molecular mechanism allowing UQ synthesis in the absence of O2 and searched for the anaerobic processes that UQ is fueling in such conditions. We found that UQ biosynthesis involves anaerobic hydroxylases, i.e. enzymes able to insert a O atom in the absence of O2. We also found that anaerobically synthesized UQ can be used for respiration on nitrate and synthesis of pyrimidine. Our findings are likely to be applicable to most facultative anaerobes, which count many pathogens (Salmonella, Shigella, Vibrio) and will help in unravelling microbiota dynamics.
Orpinolide disrupts a leukemic dependency on cholesterol transport by inhibiting the oxysterol-binding protein OSBP
Authors: Cigler Marko , Imrichova Hana , Frommelt Fabian , Depta Laura , Rukavina Andrea , Kagiou Chrysanthi , Hannich J. Thomas , Mayor-Ruiz Cristina , Superti-Furga Giulio , Sievers Sonja , Laraia Luca , Waldmann Herbert , Winter Georg E. 
Published: March 2023

AbstractMetabolic alterations in cancer precipitate in associated dependencies that can be therapeutically exploited. To meet this goal, natural product inspired small molecules can provide a resource of invaluable chemotypes. Here, we identify orpinolide, a synthetic withanolide analog with pronounced anti-leukemic properties via orthogonal chemical screening. Through multi-omics profiling and genome-scale CRISPR/Cas9 screens, we identify that orpinolide disrupts Golgi homeostasis via a mechanism that requires active phosphatidylinositol 4-phosphate (PI4P) signaling at the endoplasmic reticulum (ER)-Golgi membrane interface. Thermal proteome profiling and genetic validation studies reveal the oxysterol-binding protein OSBP as the direct and phenotypically relevant target of orpinolide. Collectively, these data reaffirm sterol transport as a therapeutically actionable dependency in leukemia and motivate ensuing translational investigation via the probe-like compound orpinolide.
Mature microRNA-binding protein QKI promotes microRNA-mediated gene silencing
Authors: Min Kyung-Won , Jo Myung Hyun , Song Minsuk , Ko Seungbeom , Lee Ji Won , Shim Min Ji , Kim Kyungmin , Park Hyun Bong , Ha Shinwon , Mun Hyejin , Polash Ahsan , Hafner Markus , Cho Jung-Hyun , Kim Dong-San , Hohng Sungchul , Kang Sung-Ung , Yoon Je-Hyun 
Published: March 2023

ABSTRACTAlthough Argonaute (AGO) proteins have been the focus of microRNA (miRNA) studies, we observed AGO-free mature miRNAs directly interacting with RNA-binding proteins, implying the sophisticated nature of fine-tuning gene regulation by miRNAs. To investigate microRNA-binding proteins (miRBPs) globally, we analyzed PAR-CLIP data sets to identify RBP quaking (QKI) as a novel miRBP for let-7b. Potential existence of AGO-free miRNAs were further verified in genetically engineered AGO-depleted human and mouse cells. We have shown that QKI serves as an auxiliary factor empowering AGO2/let-7b-mediated gene silencing. Depletion of QKI decreases interaction of AGO2 with let-7b and target mRNA, consequently controlling target mRNA decay. QKI, however, also suppresses the dissociation of let-7b from AGO2, and slows assembly of AGO2/miRNA/target mRNA complexes at the single-molecule level. We also revealed that QKI suppresses cMYC expression at post-transcriptional level, and decreases proliferation and migration of HeLa cells, demonstrating that QKI is a tumor suppressor gene by in part augmenting let-7b activity. Our data show that QKI is a new type of RBP implicated in the versatile regulation of miRNA-mediated gene silencing.
Measuring the intention-behavior gap in service failure and recovery: the moderating roles of failure severity and service recovery satisfaction
Authors: de Mesquita Jose Marcos Carvalho , Shin Hyunju , Urdan Andre Torres , Pimenta Marco Tulio Campos 
Published: March 2023

PurposeThe intention-behavior gap that occurs when one’s actions do not align with their intentions has been the topic of interest of many researchers. However, the effects of the various constructs that influence the intention-behavior gap in service failure and recovery remain under-explored to date. To fill this gap, this study aims to examine the relationship between switching intention (i.e. intention) and customer exit (i.e. behavior) and the moderating roles of failure severity and service recovery satisfaction.Design/methodology/approachTo test the proposed hypotheses, the authors used a longitudinal panel involving 821 customers who actually experienced a service failure and recovery in 38 fitness centers in Brazil. The data analysis is composed of logistic regression and cross-tabulation.FindingsThe results confirmed the significant role of switching intention on customer exit and the moderating effect of failure severity (but not service recovery satisfaction) in the relationship between switching intention and customer exit. Most of all, switching intention had low explanatory power for customer exit, confirming the presence of the intention-behavior gap. The authors further identified a weaker presence of the intention-behavior gap for female (vs male) customers and for those who experienced process failure (vs outcome failure).Research limitations/implicationsAlthough the authors confirmed the intention-behavior gap, the biggest proportion of the variance remains unexplained. Thus, it is important to explore the roles of other possible drivers, moderators and mediators.Practical implicationsAs switching intention is not a strong predictor of customer exit, managers should not assume that those who appear to be on the verge of switching will immediately exit the service provider.Originality/valueAs researchers question the explanatory power of intention for actual behavior, this paper confirms that there is an intention-behavior gap in service failure and recovery. Moreover, given that most researchers have focused on the positive outcomes of service recovery efforts, such as customer loyalty and commitment, studying negative outcomes, including switching intention and customer exit, is a key contribution of this research.
Impact of crude prices shock on GDP growth: using a linear, nonlinear and extreme value framework
Authors: Bhadury Soumya , Das Satadru , Ghosh Saurabh , Gopalakrishnan Pawan 
Published: March 2023

Purpose
Rising crude oil prices are likely to have an asymmetric and nonlinear negative impact on GDP growth. The purpose of this paper is to ask the following questions: Does the effect of a crude price shock depend on the position of crude price cycle, i.e. is the effect of price shock larger/smaller in periods of already elevated crude price? And, does the effect of crude price shock depend on the position of the economy in the business cycle, i.e. does the crude price shock affect growth differentially in periods of low/high growth?

Design/methodology/approach
The authors use a local linear projection (LLP) model to examine the asymmetric impact of crude price on GDP growth in an environment of high crude price. Next, a quantile regression model is used to account for differential impact on growth around high and low growth periods.

Findings
Results from the LLP model show that when oil price is above $70, each additional percentage point of increase in oil price results in a 20 basis point (bps) drop in quarterly GDP growth rate on average. The impact is felt between the third and sixth quarters. When oil prices rise above $80, the impact is similar, with a sharper drop in growth (30 bps). The exercise with quantile regression shows that the impact of an increase in crude prices on growth is almost double at lowest quantiles of growth compared with the median.

Originality/value
There is a growing literature that evaluates the impact of oil price in developing economies. However, nonlinearities in crude price-GDP growth dynamics have not received enough attention, especially during phases of elevated crude price or a growth downcycle. The authors believe that accounting for such effects is especially relevant in the present economic scenario of high oil prices because of geopolitical crises and a period of vulnerable growth because of supply chain issues arising out of the pandemic. Using recent data from oil-importing emerging market economies such as India, this paper fills a crucial gap in the literature.
Using social exchange and equity theory to explore postgraduate student mentoring initiatives and academic faculty participation
Authors: Bordogna Claudia M. 
Published: March 2023

PurposeStudent welfare and wellbeing is crucial to successful postgraduate study, regardless of the global location in which the study is taking place, making it an international issue. This study sought to add to the conversations occurring globally on this topic, focusing particularly on exploring academic faculty participation in higher education postgraduate taught (PGT) student mentoring initiatives.Design/methodology/approachBy applying two theories, social exchange theory (SET) and equity theory (ET), faculty participation in postgraduate mentoring was explored and examined. A qualitative methodology, comprising 19 semi-structured interviews with faculty participating as mentors, was conducted. Data was analysed using template analysis, with SET and ET used to create thematic templates.FindingsThe application of SET and ET enabled faculty participation to be understood in terms of the perceived equity, costs and rewards of mentoring. Costs can be significant, sometimes outweighing the benefits, thus endangering the viability and sustainability of the PGT mentoring initiative. Analysis suggested two distinct types of “mentor mindsets” exist, which influence the perception of investments, equity, costs and rewards.Originality/valueAs higher education institutions face increasing pressure to support student welfare, it is imperative that personalised support is put under scrutiny so management practices can be established that support and encourage academic faculty participation in these support initiatives. This paper recommends how institutions can allay the costs of mentoring by considering mentor recruitment, selection, training and other supportive measures.
Addressing employee turnover in retail through CSR and transformational leadership
Authors: Chandra Snehal , Ghosh Piyali , Sinha Saitab 
Published: March 2023

PurposeEmployee turnover, a reality that Indian retail organizations cannot ignore, is the central theme of this paper. The authors have aimed to empirically establish corporate social responsibility initiatives (CSRI) and transformational leadership (TL) as rather unconventional predictors that can potentially influence retail employees’ intention to stay (ITS) through sequential mediation by employer branding (EB) and organizational identification (OI).Design/methodology/approachData collected using a structured questionnaire from three hundred and five frontline employees working with twenty-nine Indian retail outlets in the Delhi-National Capital Region (NCR) region was tested using structural equation modelling.FindingsFindings confirmed the impact of both CSRI and TL on ITS, with sequential mediation by EB and OI. While OI partially mediated the effect of EB on ITS, TL exerted more influence than CSRI in enhancing EB.Originality/valueThis study enhances retail literature by empirically testing a unique fusion of organization and individual-level predictors that influence ITS as an individual-level outcome. Having TL and a firm corporate philosophy of CSR spending can enhance a retailer’s image as a preferred employer brand and generate OI to successfully address employee turnover
Effect of boundary slip on elastohydrodynamic lubrication with arbitrary entrainment angle in elliptical contacts
Authors: Cao Lei , Cai Jianlin , Wang Cheng , Yang Tianyou , Zhou Wei , Wang Liwu 
Published: March 2023

Purpose
The purpose of this study is to describe and observe the influence of boundary slip associated with an arbitrary entrainment angle on the contact lubrication properties of ellipses.

Design/methodology/approach
Based on the modified Reynolds equation, the boundary slip of any angle is considered in the elliptic contact, and numerical simulation is carried out. In the above calculation, the progressive mesh densification method is used, which greatly reduces the computation time.

Findings
The results indicate that the variation of film thickness corresponding to different entrainment angles is distinct from those without considering boundary slip. In addition, boundary slip reduces the central film thickness and minimum film thickness, which makes the hydrodynamic pressure distribution smoother.

Originality/value
The present study focuses on the specific condition with the arbitrary direction of rolling and sliding velocity found in hypoid gears and worm, and some other components. The influence of boundary slip associated with arbitrary entrainment angle on the lubrication film thickness in elliptical contacts is first revealed, which improves a good understanding of elastohydrodynamic lubrication characteristics.
Technical accounting resources as performative topoi for sustainability
Authors: Caron Marie-Andrée , Fortin Anne 
Published: March 2023

PurposeThe purpose of this study is to explore the potential for technical accounting resources to help professional accountants exercise their performative agency.Design/methodology/approachThe authors combine the integrative learning theory of truth and the concept of performativity, including two approaches to sustainability education and interventions, to construct a grid for coding the technical resources provided by the UK's Institute of Chartered Accountants in England and Wales, a pioneer in sustainability advocacy.FindingsThe findings suggest the dominance of the “predetermined and expert-determined” approach. They also reveal the emergence of three levels of performative topoi based on the relative presence of the “predetermined and expert-determined” and “process-of-seeking” approaches to professional interventions toward sustainability. The results show the profession's evolving contribution to the construction of actionable knowledge.Research limitations/implicationsThe main limitation of this research is that it draws on a limited corpus. In addition, the use of a binary code to represent the presence/absence of a code does not convey the code's quantitative importance.Practical implicationsThe results are useful for those wanting to produce technical accounting resources that are more likely to help professionals build actionable knowledge and contribute to accountants' interventions toward sustainability.Social implicationsFindings suggest the need for reflection on how the accounting profession can best contribute to implementing sustainability in organizations.Originality/valueFew studies deconstruct professional technical resources to see how a profession can contribute to a process of societal change.
Identifying total defense logistics concepts: a comparative study of the Swedish pandemic response
Authors: Antai Imoh , Hellberg Roland 
Published: March 2023

Purpose
The total defence (TD) concept constitutes a joint endeavour between the military forces and civil defence structures within a TD state. Logistics is essential for such joint collaboration to work; however, the mismatch between military and civil defence logistics structures poses challenges for such joint collaboration. The purpose of this paper is to identify logistics concept areas within the TD framework that allow for military and civil defence collaborations from a logistics operations perspective.

Design/methodology/approach
Pattern-matching analysis is used to compare patterns found in the investigated case with those prescribed from the literature and predicted to occur. The study seeks to identify logistics concepts within TD from the literature and from the events describing the Swedish response to the Covid-19 pandemic. Pattern matching thus allows for the reconciliation of logistics concepts from the literature to descriptions of how the response was handled, albeit under a TD framework.

Findings
Findings show quite distinct foci between the theoretical and observational realms in terms of logistics applications. While the theoretical realm identifies four main logistics concepts, the observational realm identifies five logistics conceptual themes. This goes on to show an incongruence between the military and civil parts of the TD.

Research limitations/implications
This study provides basis for further research into the applications and management of logistics activity within TD and emergency response.

Originality/value
Logistics applications within TD have not, until now, received much attention in the literature. Given this knowledge gap, this study is of original value.
The landscape of public procurement research: a bibliometric analysis and topic modelling based on Scopus
Authors: Rejeb Abderahman , Rejeb Karim , Appolloni Andrea , Kayikci Yasanur , Iranmanesh Mohammad 
Published: March 2023

Purpose
The purpose of this study is to investigate the structure and dynamics of academic articles relating to public procurement (PP) in the period 1984–2022 (up to May). The researchers also intend to analyse how this knowledge domain has grown since 1984.

Design/methodology/approach
A bibliometric analysis was carried out to examine the existing state of PP research. Based on 640 journal articles indexed in the Scopus database and written by 1,247 authors over nearly four decades, a bibliometric analysis was conducted to reveal the intellectual structure of academic works pertaining to PP.

Findings
Findings reveal that PP research from Scopus has significantly increased in the past decade. Major journals publishing PP research are International Journal of Procurement Management, Journal of Cleaner Production, Journal of Purchasing and Supply Management and Public Money and Management. Results also indicate that authors’ cooperation network is fragmented, showing limited collaboration among PP researchers. In addition, results suggest that the institutional collaboration network in PP research mirrors what is commonly referred to as the North–South divide, signifying insufficient research collaboration between developed and developing countries’ institutions. According to the co-occurrence keyword network and topic modelling, PP revolves around five main themes, including innovation, corruption, sustainable and green PP, PP contracts and small and medium enterprises. Based on these results, several directions for future research are suggested.

Social implications
This paper provides an increased understanding of the entire PP field and the potential research directions.

Originality/value
To the best of the authors’ knowledge, this study is the first-ever application of bibliometric techniques and topic modelling to examine the development of PP research since 1984 based on scholarly publications extracted from the Scopus database.
Facilitating a culture of sustainable innovation: a cooperative advantage perspective
Authors: Prieto Leon C. , Phipps Simone T.A. , Reynolds Stacey D. , Hannah Anthony Lenard 
Published: March 2023

Purpose
The purpose of this paper is to provide advice on how organizations can facilitate a culture of sustainable innovation from a cooperative advantage perspective.

Design/methodology/approach
This paper is written for practitioners and academics focused on sustainable innovation. It includes specific advice for production & operations and accounting & finance functions and how they can contribute to sustainable innovation from a cooperative advantage perspective.

Findings
By emphasizing the importance of stakeholder wellbeing, creating opportunities for collaboration and empowering employees, human resources (HR) departments can help organizations cultivate a culture of sustainable innovation and navigate the complex challenges of addressing environmental concerns to build a more sustainable future.

Originality/value
This paper offers HR practitioners a unique approach to encourage a culture that promotes care and community, intentional dialogue and action-oriented consensus-building among employees in different departments to facilitate sustainable innovation from a cooperative advantage perspective within their respective organizations.
The effect of the informal economy on bilateral exports from sub‐Saharan African countries
Authors: Poumie Boker , Noubissi Domguia Edmond , Augustin Ngounou Borice , Messie Pondie Thierry , Nzomo Tcheuta Joseph 
Published: March 2023

AbstractThe purpose of this study is to analyse the impact of the informal economy on bilateral exports in sub‐Saharan African countries. We use a gravity model, to which we add indicators of the informal economy and indicator variables for different economic regions. The study used Pseudo‐Poisson Maximum Likelihood (PPML) and Heckman estimation techniques on data from the period 2002–2018. The results show that the informal economy has a negative impact on bilateral inter‐community exports and a positive impact on bilateral intra‐community exports. These results thus support the idea that the informal economy can accelerate the integration of regional economic communities and ultimately facilitate the establishment of bilateral export free trade areas at the continental level.