bluuebunny/crossref_metadata_2025_split huggingface dataset:
Xylazine co-self-administration suppresses fentanyl consumption during self-administration and induces a unique sex-specific withdrawal syndrome that is not altered by naloxone in rats
Authors: Khatri Shailesh N. , Sadek Safiyah , Kendrick Percell T. , Bondy Emma O. , Hong Mei , Pauss Sally , Luo Dan , Prisinzano Thomas E. , Dunn Kelly E. , Marusich Julie A. , Beckmann Joshua S. , Hinds Terry D. , Gipson Cassandra D. 
Published: May 2023

AbstractPrescription and illicit opioid use are a public health crisis, with the landscape shifting to fentanyl use. Since fentanyl is 100-fold more potent than morphine, its use is associated with a higher risk of fatal overdose that can be remediated through naloxone (Narcan) administration. However, recent reports indicate that xylazine, an anesthetic, is increasingly detected in accidental fentanyl overdose deaths. Anecdotal reports suggest that xylazine may prolong the fentanyl “high”, alter the onset of fentanyl withdrawal, and increase resistance to naloxone-induced reversal of overdose. To date no preclinical studies have evaluated the impacts of xylazine on fentanyl self-administration (SA; 2.5 μg/kg/infusion) or withdrawal to our knowledge. We established a rat model of xylazine/fentanyl co-SA and withdrawal and evaluated outcomes as a function of biological sex. When administered alone, chronic xylazine (2.5 mg/kg, IP) induced unique sex-specific withdrawal symptomatology whereby females showed delayed onset of signs and a possible enhancement of sensitivity to the motor-suppressing effects of xylazine. Xylazine reduced fentanyl consumption both male and female rats regardless of whether it was experimenter-administered or added to the intravenous fentanyl product (0.05. 0.10, and 0.5 mg/kg/infusion) when compared to fentanyl SA alone. Interestingly, this effect was dose-dependent when self-administered intravenously. Naloxone (0.1 mg/kg, SC) did not increase somatic signs of fentanyl withdrawal, regardless of the inclusion of xylazine in the fentanyl infusion in either sex; however, somatic signs of withdrawal were higher across timepoints in females after xylazine/fentanyl co-SA regardless of naloxone exposure as compared to females following fentanyl SA alone. Together, these results indicate that xylazine/fentanyl co-SA dose-dependently suppressed fentanyl intake in both sexes, and induced a unique withdrawal syndrome in females which was not altered by acute naloxone treatment.
Participant perceptions and experiences of a novel community-based pilot respiratory longitudinal sampling method in Liverpool, UK
Authors: German E.L. , Nabwera H.M. , Robinson R. , Shiham F. , Liatsikos K. , Parry C.M. , McNamara C. , Kattera S. , Carter K. , Howard A. , Pojar S. , Hamilton J. , Matope A. , Read J. , Allen S.J. , Hill H. , Hawcutt D.B. , Urban B.C. , Collins A.M. , Ferreira D.M. , Nikolaou E. 
Published: May 2023

AbstractLongitudinal, community-based sampling is important for understanding prevalence and transmission of respiratory pathogens. Using a minimally invasive sampling method, the FAMILY Micro study monitored the oral, nasal and hand microbiota of families for 6 months. Here, we explore participant experiences and opinions.A mixed methods approach was utilised. A quantitative questionnaire was completed after every sampling timepoint to report levels of discomfort and pain, as well as time taken to collect samples. Participants were also invited to discuss their experiences in a qualitative structured exit interview.We received questionnaires from 36 families. Most adults and children >5y experienced no pain (94% and 70%) and little discomfort (73% and 47% no discomfort) regardless of sample type, whereas children ≤5y experienced variable levels of pain and discomfort (48% no pain but 14% hurts even more, whole lot or worst; 38% no discomfort but 33% moderate, severe, or extreme discomfort). The time taken for saliva and hand sampling decreased over the study.We conducted interviews with 24 families. Families found the sampling method straightforward, and adults and children >5y preferred nasal sampling using a synthetic absorptive matrix over nasopharyngeal swabs. It remained challenging for families to fit sampling into their busy schedules. Adequate fridge/freezer space and regular sample pick-ups were found to be important factors for feasibility. Messaging apps proved extremely effective for engaging with participants.Our findings provide key information to inform the design of future studies, specifically that self-sampling at home using minimally invasive procedures is feasible in a family context.
Tsunami-resilient building guidelines for Sri Lankan coastal belt: a critical review and consolidation based on significant institutional perceptions
Authors: Gunarathna Udari , Bandara Chaminda Senarathna , Dissanayake Ranjith , Munasinghe Harsha 
Published: May 2023

Purpose
The lessons learned from the 2004 tsunami phenomenon fueled the government and other local authorities to strengthen the legitimate background to mitigate such devastation in future events. This study aims to propose a standardized tsunami-resilient construction guideline for Sri Lanka by integrating existing local and international standards.

Design/methodology/approach
A comprehensive literature survey was carried out to undertake the study, with a wide-ranging content and thematic analysis of existing tsunami-resilient construction aspects in Sri Lanka. Integrating all existing guidelines with international standards, finally, a consolidated guideline with significant tsunami-resilient building aspects was proposed for stakeholders involved with the resilient built environment in tsunami-prone areas, particularly during the building construction in the coastal belt.

Findings
The existing tsunami-resilient guidelines in Sri Lanka follow similar aspects but in different dimensions. Compared to the international standards, few significant aspects create a gap in local guidelines. Thus, the findings demonstrated that the existing local guidelines must be modified and strengthened by mainstreaming into international practices.

Research limitations/implications
Existing guidelines are more concerned with structural aspects. Nevertheless, proper integration of local and international guidelines would be more favorable to minimizing existing local guidelines’ gaps. Further, a standardized tsunami-resilient building guideline would be a referring document for all stakeholders in tsunami-resilient constructions.

Practical implications
By aligning local guidelines with international standards, the reliability of the guidelines will be increased and direct the built environment to quality disaster-resilient constructions.

Social implications
Through a standardized guideline, the community can rely on tsunami-resilient construction in coastal cities.

Originality/value
The consolidated guideline further contains the essentials of city resilience in tsunamis and would be an excellent reference for relevant stakeholders than aligning with several guidelines.
Employee innovative job performance and firms' financial performance: a multilevel insight with big data analytics and entrepreneurial orientation
Authors: Mahmood Faisal , Saleem Maria , Ariza-Montes Antonio , Han Heesup 
Published: May 2023

PurposeThe present research developed and investigated a multilevel theoretical framework by underpinning a resource-based view (RBV) that uncovers how and when academic researchers and organizational practitioners can strategically attain a competitive edge and increase their financial performance.Design/methodology/approachTo consider the dynamic and ever-challenging business environment, this research examined the contingency of big data analytics (BDA) and entrepreneurial orientation (EO). The multi-source and multilevel data used for this research were gathered from 195 manufacturing firms listed on the Pakistan stock exchange by employing a time-lagged design and survey strategy. Additionally, for hypothesis testing, multilevel path analysis was conducted in MPlus.FindingsThe authors uncovered the sequential mediation mechanisms of organizational innovation (OI) and competitive advantage (CA) on the relationship between individual-level employee innovative job performance (EIJP) and firms' financial performance (FFP) based on the resource-based view. The authors noted positive and significant sequential mediation of OI and CA on the effect of EIJP on FFP. Similarly, the relationship between EIJP and OI was found to be stronger when the boundary conditions of BDA and EO were higher than when they were lower.Originality/valueThis research offers new practical insights for managers and organizational practitioners to better value their EIJP, and due diligence is required when employing BDA and EO to attain a competitive edge over competitors and increase financial performance.
Influence of film destination placement on travel intention: mediating effect of involvement and place attachment
Authors: Chen Pei-Ti 
Published: May 2023

Purpose
This study aims to examine the public’s acceptance of film-induced tourism and develops the relationship among placement marketing, involvement, place attachment and travel intention. The film Your Love Song shot in the Hualien and Taitung regions in Taiwan was selected as the case study.

Design/methodology/approach
An online sample survey was conducted using a structured questionnaire, and statistical tests and overall structural equation modeling analysis using the SPSS and AMOS statistical software packages, respectively, were performed.

Findings
This study results demonstrate that destination placement marketing has a significant positive effect on the level of destination involvement, place attachment and travel intention of viewers. Moreover, the level of involvement has some intermediary effect on the interrelationship between placement marketing and travel intention. Hence, this study suggests that relevant government agencies and tourism operators should promote local tourism through films and television shows and attract more tourists by retaining the original shooting scenes.

Originality/value
While previous studies have only analyzed two or three of the four concepts of film-induced tourism, placement marketing, travel intention, involvement and place attachment, this study completely integrates these four concepts and proves the correlation between them.
Assessing the Zoom learning experience of the elderly under the effects of COVID in Hong Kong: application of the IPO model
Authors: Ching Larry K.W. , Lee Carol Y.K. , Wong Chris K.P. , Lai Michael T.H. , Lip Amy 
Published: May 2023

Purpose
This study aims to investigate the perceptions of elderly learners in experiencing Zoom learning under the effects of COVID in the case of Hong Kong.

Design/methodology/approach
An online survey and focus group interviews have been conducted with quantitative and qualitative approaches, respectively. The survey design was based on the input-process-output (IPO) model conceptual framework and used to assess students’ perceptions regarding their Zoom learning experiences at the Elder Academy of Hong Kong Metropolitan University. Thereafter, selected students were invited to participate in focus group interviews to offer more in-depth comments for analysis purposes. Statistical Product and Service Solutions software and SmartPLS were used for data analysis of the survey, and content analysis was used to summarize opinions from the focus group interviews; thus, a comprehensive picture of elderly learners’ learning experiences on Zoom is presented.

Findings
An overall positive perception was the result of elderly learners’ Zoom learning journeys, particularly in the “input” and “process” stages of the IPO model. Yet, their perception of the “learning outcomes achieved” level in the “output” stage was lower among the rest, thus strongly affected by the factors of “interactions” and “teaching” experienced by elderly learners on Zoom. Although the perception of the youngest age group was more positive, none have agreed that Zoom learning was more favourable when compared with the traditional face-to-face mode.

Originality/value
Given Zoom as the short-term replacement option under the COVID pandemic, this study will provide recommendations for educators/institutions to improve their design of the whole learning process for elderly learners on the Zoom platform.
University faculty’s informal learning and professional reflections: text mining for processing interviews
Authors: Park Kyung Hee , Li He , Liu Chang 
Published: May 2023

Purpose As university faculty faced new challenges, such as rapid digital social and the coronavirus disease 2019 (COVID-19) response, this study aimed to identify the daily changes in the interaction between the faculty and the organizational environment (colleague, policy and new issue) by exploring their recent dynamic educational efforts and the professional development.Design/methodology/approach This is a study wherein perceptions of 20 faculty from 15 universities and colleges were collected through in-depth online interviews. The authors analyzed interview data by arranging and visualizing the analyzed data using network clustering. Further, they applied the Latent Dirichlet allocation of the topic modeling to monitor the appropriate number of clusters, ultimately determined as four clusters using partial clustering.Findings The results showed that university faculty spontaneously tried to solve the problems through informal learning while the commitment to peer learning was deepening, reflecting the collectivist orientation nature of Chinese culture. Besides, the faculty also required support to reflect on their daily efforts for professional development. These results about their various learning routines prove the justification for the faculty's professional development to be discussed from the “learning by doing” perspective of lifelong learning.Originality/value This study proved the significance of informal learning for university faculty's professional development and the reasonable value of peer learning, and provided insights into how the Chinese context may influence university faculty's informal learning experience.
Investigating the self-employed: the South African perspective
Authors: Muchemwa Marifa , Odimegwu Clifford 
Published: May 2023

Purpose
In a country that is marred by an excessively high unemployment rate, there is a need for policymakers to prioritise entrepreneurship in South Africa. The study aims to explore the determinants of self-employment among the youth in South Africa and in the process answer the following question: Who are the self-employed youths in South Africa?

Design/methodology/approach
Different potential predictors of self-employment empirically used in the literature were used in this study. A probit regression model was used with the binary self-employment variable as the dependent variable and a host of independent variables. A nationally representative survey consisting of youths was used in the analysis.

Findings
The findings show that financial literacy increases the odds of being self-employed. Secondly, the odds of being self-employed increase with age as mature people are expected to have gathered enough networks and wisdom over the years. Thirdly, being male decreases the odds of being self-employed. When it comes to education, the only category that statistically increases the odds of being self-employed compared with no schooling is the tertiary level of education. The other educational levels are all statistically insignificant. From a policy perspective, the government should promote self-employment by investing in financial literacy as well as increasing access to tertiary education among disadvantaged groups.

Originality/value
The study is one of the first, to the best of the authors’ knowledge, to examine the characteristics of the self-employed using a nationally representative survey in South Africa.
Modelling the operational maturity challenges faced by online food ordering and delivery enterprises during Covid-19 lockdown in Oman: a fuzzy interpretive structural modelling approach
Authors: Abbas Haidar , Fatima Paikar , Akaak Abdul-Aziz Mustahil Ahmed Ali , Frederico Guilherme F. , Kumar Vikas 
Published: May 2023

Purpose
This research aims to ascertain the various operational maturity challenges faced by the online food ordering and delivery enterprises (OFODE), their nature and their interactive relationships. In particular, this paper aims to (a) identify the most relevant operational maturity challenges faced by the OFODE during the COVID-19 lockdown in Oman, (b) explore and establish any likely structural relationship among these challenges and (c) put them into logical clusters.

Design/methodology/approach
Experts helped to reduce the 18 initially identified maturity challenges to 13 most pressing ones. Mutual relationships, dominance of interactions and their classifications were explored using fuzzy interpretive structural modeling (FISM) and fuzzy MICMAC analysis.

Findings
The study of situation-specific operational maturity challenges convinced the authors to propose a distinct FISM model that depicts the relationship among these challenges. Keeping commissions and fees reasonable emerges as the challenge which all other challenges seemingly culminate into. One of the most important situation-specific challenges (i.e. customer confidence about infection free delivery) emerges as a linkage challenge which aggravates as well as is aggravated by certain challenges.

Research limitations/implications
Besides enriching literature, the proposed model has implications for practitioners particularly when the similar lethal waves are experienced anywhere. The number of respondents, subjective approach, specific context as well as the geographical area coverage are the key limitations.

Originality/value
To the best of the authors’ knowledge, this study is the first known scientific effort which attempts to model the operational maturity challenges faced by the OFODE during COVID-19 lockdown period. The authors used the FISM modeling approach to forge these interrelated challenges into a structural model.
A research agenda at the intersection of sport sponsorship and service
Authors: Cornwell T. Bettina , Frank Abby , Miller-Moudgil Rachel 
Published: May 2023

PurposeThe purpose of this work is (1) to supply a framework of actors in sport sponsorship and articulate the service relationships that support these partnerships and (2) to propose research questions in this space that are unaddressed and forward-looking.Design/methodology/approachSponsorship is part of a complex network of actors and service relationships found in sport. The sports team, activity, or event is a sport property, often with long-term and dynamic service relationships. The authors consider how a sponsor's relationship with the sport property intersects with organizing bodies, venues, communities and society. The authors identify clusters of actors that interact with and influence other clusters (e.g. governing bodies, media, host community and venue/teams/fans) within an ecosystem, paying special attention to aspects of co-creation and co-destruction and the feedback loops that cause them.FindingsThrough this analysis, the authors identify areas of needed research at the intersection of sport sponsorship and service. The model synthesizes the literature from service-dominant logic, sports, sponsorship, systems thinking and co-creation/co-destruction research areas. Using the model and relevant cases, the authors can better understand the complexities of sport service relationships and advance research at the intersection of sport sponsorship and service.Originality/valueThis is the first sport sponsorship service ecosystem model. It is also the first integration of systems thinking with constructs in sport sponsorship and services.
UK commercial real estate valuation practice: does it now build in sustainability considerations?
Authors: Hossain Syeda Marjia , van de Wetering Jorn , Devaney Steven , Sayce Sarah 
Published: May 2023

PurposeThis paper investigates the extent to which commercial property valuers in the UK refer to Royal Institution of Chartered Surveyors (RICS) professional standards and guidance on the inclusion of sustainability in valuation reports. Data collection, analysis and reporting related to sustainability attributes is examined, as well as the perceived importance of these attributes to clients and any value impacts that are associated with them.Design/methodology/approachAn online survey of UK commercial property valuers was conducted from July to September 2019. The survey included both structured and open-ended questions.FindingsReference to RICS standards and guidance on sustainability has improved since earlier research. However, progress on data collection is still limited. At the time of the survey, UK valuers indicated that sustainability attributes were of more importance to owner-occupiers than investors and lenders. UK valuers also indicated that, out of a range of sustainability attributes, only certification was influencing market value (MV) and investment value (IV) to any great extent.Research limitations/implicationsThe online survey had 53 responses and this limited the ability to draw definitive conclusions. Hence, whilst the results may be indicative of the perceptions of some valuers of the significance of sustainability-related matters in the UK, the sample is not large enough to be considered representative of the opinions of property valuers per se in the UK.Practical implicationsExplicit reflection of sustainability in market or investment values is still limited in the UK valuation practice, but there are challenges faced by valuers that need further investigation, including difficulties in pricing sustainability attributes.Originality/valueThis is the first empirical investigation of the perception of sustainability by valuers in the UK commercial property market since the 2012 survey reported by Michl et al. (2016).
Enhancing affective commitment through gamified services of luxury brands: role of game mechanics and self-congruity
Authors: Saxena Garima , Jain Sheetal , Mishra Sita 
Published: May 2023

PurposeThis study aims to examine the effect of consumers’ gaming motivations on customer–brand engagement and the potential of this engagement to develop self–brand connections and affective commitment toward luxury brands. Second, it explores if the setup game mechanics and self-congruity with the brand can strengthen the effectiveness of motivation to engage with gamification on customer–brand engagement and self-brand connection.Design/methodology/approachData were collected through the survey method using a structured questionnaire. The sample comprised 249 millennial luxury consumers in India. Data analysis was conducted using AMOS 25 and PROCESS Macro for SPSS.FindingsThe findings support the mediating role of customer–brand engagement and self–brand connection in the relationship between motivation to engage with gamification and affective commitment. While setup game mechanics and self-congruity with brand positively moderate the effect of motivation to engage with gamification on affective commitment via self–brand connection, a similar effect is not found for the relationship via customer–brand engagement. This study presents important implications for both marketers and academicians.Originality/valueThis study applies the mechanics–dynamics–emotions framework and social exchange theory to explain gamified services as a cocreation process between consumers and luxury brands, fostering customer engagement, connection and commitment with the brands. It highlights the role of setup game mechanics and self-congruity in strengthening the effect of luxury consumers’ gaming motivations on engagement and connection with the brand.