bluuebunny/crossref_metadata_2025_split huggingface dataset:
A cluster randomized trial assessing the impact of personalized prescribing feedback on antibiotic prescribing for uncomplicated acute cystitis to family physicians
Authors: Carney Greg , Maclure Malcolm , Patrick David M. , Fisher Anat , Stanley Dana , Bassett Ken , Dormuth Colin R. 
Published: July 2023

Objective
To evaluate the impact of personalized prescribing portraits on antibiotic prescribing for treating uncomplicated acute cystitis (UAC) by Family Physicians (FPs).

Design
Cluster randomized control trial.

Setting
The intervention was conducted in the primary care setting in the province of BC between December 2010 and February 2012.

Participants
We randomized 4 833 FPs by geographic location into an Early intervention arm (n = 2 417) and a Delayed control arm (n = 2 416).

Intervention
The Education for Quality Improvement in Patient Care (EQIP) program mailed to each FP in BC, a ‘portrait’ of their individual prescribing of antibiotics to women with UAC, plus therapeutic recommendations and a chart of trends in antibiotic resistance.

Main outcome measures
Antibiotic prescribing preference to treat UAC.

Results
Implementing exclusion criteria before and after a data system change in the Ministry of Health caused the arms to be unequal in size–intervention arm (1 026 FPs, 17 637 UAC cases); control arm (1 352 FPs, 25 566 UAC cases)–but they were well balanced by age, sex and prior rates of prescribing antibiotics for UAC. In the early intervention group probability of prescribing nitrofurantoin increased from 28% in 2010 to 38% in 2011, a difference of 9.9% (95% confidence interval [CI], 9.1% to 10.7. Ciprofloxacin decreased by 6.2% (95% CI: 5.6% to 6.9%) and TMP-SMX by 3.7% (95% CI: 3.1% to 4.2%). Among 295 FPs who completed reflective surveys, 52% said they were surprized by the E. coli resistance statistics and 57% said they planned to change their treatment of UAC.

Conclusion
The EQIP intervention demonstrated that feedback of personal data to FPs on their prescribing, plus population data on antibiotic resistance, with a simple therapeutic recommendation, can significantly improve prescribing of antibiotics.
Trial registration: ISRCTN 16938907.
Fasting Lipid Profile as a Predictor of Mortality and Morbidity in Dengue Hemorrhagic Fever
Authors: Rajalakshmi Kandasamy Venkatraju  , Boopathy Rajan Padmanabhan  , Bathragiri Marasamy  
Published: July 2023

BACKGROUND
Dengue is a tropical disease which is a major cause of preventable mortality. It is essential to identify people who are at risk for progression to dengue hemorrhagic fever and dengue shock syndrome. Hence the search for an optimal biomarker which can identify patients at risk of progression to severe dengue is on. Some studies have indicated hypolipidemia to be a marker for the identification of critically ill patients. This study intended to find out the relationship between fasting lipid profile and dengue mortality and morbidity.
METHODS
This was a comparative cross-sectional study conducted for 1 year at a Government hospital setup with a sample size of 132.
RESULTS
Out of the 132 patients, all patients had bleeding manifestations ranging from purpuric rashes to melena. 92 patients had capillary leak syndrome and 52 patients developed shock. Most of the patients who developed bleeding manifestations, capillary leakage and shock were found to have hypocholestrolemia and HDL<50mg/dl.
CONCLUSIONS
It can be concluded that serum fasting lipid profile is an easily accessible and affordable indicator for early identification of patients at risk of progression to severe dengue.
Atividade Física e Obesidade na Infância: Uma Revisão Integrativa
Authors: Cé Jean Augusto , Zanoni Eliton Marcio , Carvalho Risoní Pereira Dias de , Kades Gabriela , Fin Gracielle , Silva Bruna Becker da , Alberti Adriano 
Published: July 2023

Introdução: a obesidade é considerada um problema de saúde pública, por se tratar de uma doença crônica que está aumentando consideravelmente, principalmente entre crianças e adolescentes, acarretando uma série de complicações e agravos a saúde. Objetivo: analisar produções científicas sobre atividade física e obesidade na infância, publicadas no Brasil entre janeiro de 2018 a dezembro de 2019. Metodologia: Trata-se de uma revisão integrativa da literatura que consiste em agrupar e sintetizar conhecimentos já existentes sobre o tema. Foram utilizados estudos publicados baseados em evidências e que relacionam a atividade física e obesidade na infância, com a finalidade de sintetizar resultados de pesquisas já realizadas, além de apontar lacunas do conhecimento para realização de novos estudos. Resultados: a obesidade envolve diversas disciplinas, como nutrição, medicina, psicologia e educação física. Através das aulas de Educação Física, os professores podem colaborar com a educação em saúde orientando quanto aos cuidados com a saúde e assim agir como parceiros dos programas preventivo-educativos. Cabe também ao professor e a escola encaminhar e conscientizar os alunos sobre a importância da aquisição de um estilo de vida ativo e hábitos saudáveis, buscando incentivar a prática de atividades físicas na infância, a fim de reduzir o sedentarismo e em consequência reduzir as altas taxas de obesidade. Conclusão: atividade física desempenha papel importante como fator de prevenção e redução do excesso de peso no tratamento da obesidade, pois associando a atividade física e a implementação de programas interdisciplinares irá auxiliar na melhor qualidade de vida das crianças e adolescentes.
Prevalence of and factors associated with extraintestinal manifestations and their remission in inflammatory bowel disease: the EXTRA prospective study from the GETAID
Authors: Guillo Lucas , Savoye Guillaume , Amiot Aurélien , Gilletta Cyrielle , Nachury Maria , Dib Nina , Bourreille Arnaud , Roblin Xavier , Caillo Ludovic , Allez Matthieu , Picon Laurence , Hébuterne Xavier , Seksik Philippe , Chupin Antoine , Buisson Anthony , Brixi Hédia , Altwegg Romain , Simon Marion , Amil Morgane , Laharie David , Bouguen Guillaume , Serrero Mélanie , Elgharabawy Yasmine , Peyrin-Biroulet Laurent 
Published: July 2023

Abstract

Background and aims:
Extraintestinal manifestations (EIM) of inflammatory bowel disease (IBD) are challenging clinical situation. No prospective study assessed remission risk factors for EIMs. Study aimed to prospectively investigate the epidemiology, risk factors for EIM occurrence and EIM remission in a large IBD cohort.

Methods:
We conducted a cross-sectional study in 30 French referral centers. Between May to June 2021, all consecutive patients attending to hospital appointment were systematically invited to fill out a questionnaire.

Results:
A total of 1971 consecutive patients with IBD were analyzed. There were 1056 women (53.8%), and the median age of patients was 41 years [31; 54]. The median disease duration was 11 years [1; 18]. Overall, 544 (27.6%) had at least one EIM. In 20.2% of case, patient had multiple EIMs. The most frequent EIMs were rheumatological (19%) and dermatological (10%) manifestations. Immunosuppressant treatment (OR=2.56; p<0.001) was a risk factor for EIM, while the Montreal A3 classification (OR=0.61, p=0.023) and male gender (OR=0.61, p<0.001) were associated with a lower risk for EIM occurrence. IBD current clinical remission (OR=2.42; p<0.001) and smoking cessation (OR=2.98; p<0.001) were associated factors for EIM remission. Conversely, age at IBD diagnosis (OR=0.98; p<0.018) was associated with a lower risk of EIM remission.

Conclusion:
One quarter of patients had at least one EIM. Beyond factors associated with the presence of EIMs, patients with IBD current clinical remission and smoking cessation are more likely to achieve EIM remission, while increasing age at IBD diagnosis is associated with decreased chance of remission.
The Effect of Postponement Strategy Towards the Financial Performance of Manufacturing Companies in Malaysia
Authors: Ramasamy Sethuraman , Husin Nor Azilah 
Published: July 2023

Today’s manufacturing companies must simultaneously deal with externally increasing customers multi-item requirements with rapid lead-time, demanded high-quality products, but internally on a limited capacity. This study aims is to explore the important elements in postponement strategies and to identify the impact of postponement strategies towards financial performance of the manufacturing companies in Malaysia. Using qualitative research method, this study employs standardized open-ended interviews with five key informants from electronic manufacturing services, solar panel, telco, medical, and latex industries. ATLAS.TI was used to analysed the data. This study reveals that postponement strategies implemented have saved various costs, enhance its product quality, increase production speed, and definitely enhance their profits which results from increase revenue. Overall, this study supports the Service Level Model which suggest that by integrating demand management processes in the postponement strategies, the service level offered to customers can be achieved and it leads to the improvement on the yearly financial performance. The empirical evidence of this study provides a solid foundation for the manufacturing companies in Malaysia to incorporate postponement strategies while observing the market strategy to grab more customers for business enhancement.
Dziecko w doświadczeniu maternalnym. O wierszach Joanny Mueller
Authors: Morzyńska-Wrzosek Beata 
Published: July 2023

W neolingwistycznej poezji Joanny Mueller istotnym zagadnieniem jest indywidualny wymiar macierzyństwa. Jego liryczne konkretyzacje odznaczają się pogłębioną autorefleksyjnością, poszukiwaniem własnej poetyki, wskazywaniem na przemiany ponowoczesnej estetyki. Poetka, eksplorując możliwości języka, próbując wypowiedzieć doświadczenie maternalne, skupia się nie tylko na tożsamości matki, ale też na podmiotowości dziecka w okresie prenatalnym i niemowlęcym. Charakteryzując jego status, otwierając się na eksperymentowanie z dźwiękową i semantyczną zasobnością języka, w matczynym doświadczeniu wskazuje na radość, troskę, ale też niepewność i lęk. Odsłania potencjalność nowego bytu, znikomość jego istnienia, która wymaga skupienia i przyzwolenia, subtelnych gestów, by załagodzić napięcia towarzyszące wzrastaniu. Mueller, przedstawiając budowanie relacji z dzieckiem, podkreśla współzależność, doznawanie jego bezcenności, odrębności, stopniowe oswajanie się z tym, co nieznane, ukryte, a niezwykle bliskie.
Asymptotic modelling of viscoelastic von Kármán membrane shells
Authors: Legougui Marwa , Ghezal Abderrezak 
Published: July 2023

Abstract
The objective of this work is to study the asymptotic justification of the two-dimensional model of viscoelastic von Kármán membrane shells. More precisely, we consider a three-dimensional model for a nonlinearly viscoelastic membrane shell with a specific class of boundary conditions of von Kármán type. Using techniques from formal asymptotic analysis with the thickness of the shell as a small parameter, we show that the
scaled three-dimensional solution still leads to the two-dimensional model of viscoelastic von Kármán membrane shells.
Hölder stability estimates in determining the time-dependent coefficients of the heat equation from the Cauchy data set
Authors: Rassas Imen 
Published: July 2023

Abstract
In this paper, we address stability results in determining the time-dependent scalar and vector potentials appearing in the convection-diffusion equation from the knowledge of the Cauchy data set. We prove Hölder-type stability estimates. The key tool used in this work is the geometric optics solution.
Deciding Together as Faculty: Narratives of Unanticipated Consequences in Gendered and Racialized Departmental Service, Promotion, and Voting
Authors: Smith-Doerr Laurel , Mickey Ethel L. , Kane-Lee Ember Skye W. 
Published: July 2023

AbstractWorkplace inequalities scholarship often assumes making people aware of problems will lead to change, although gendered and racialized organizations theories show systemic problems beyond individual awareness. Still, not enough research analyzes the narratives of savvy organizational actors – like university faculty aware of inequalities – to understand the mechanisms operating against leveraging that knowledge for change. Data consist of 10 group interviews with 45 faculty across departments in one US public university, supplemented by content analysis of 56 departments’ written bylaws. Findings focus on three common shared decisions: committee service, hiring/promotion, and voting practices.We find awareness of inequality may actually reinforce the status quo when narratives about gendered and racialized processes feature decoupling from formal bylaws, and when narratives about outcomes relate to multiple layers of unanticipated consequences favoring whiteness and men.Specifically, inequality is reproduced when narratives about gendered and racialized unanticipated consequences: 1) highlight the imperviousness of change, as in the difficulty of allocating service work equitably, 2) lack reflexivity and shift responsibility to ‘other’ groups – ‘faculty’ or ‘administrators’ – as in unequal hiring and promotion decisions, and 3) focus on standard old boy stories which obscure other inequalities, as in faculty voting where non-tenure track rank inequality obscures race/gender inequalities. When unanticipated consequences narratives have dimensions of fatalism, finger pointing, and blindness to intersectionality, white men may continue to benefit. This study shows how formal policies and awareness of inequalities may still fail to produce change.
Hsa_circ_0028007 regulates the progression of nasopharyngeal carcinoma through the miR-1179/SQLE axis
Authors: Li Wenya , Jiang Xiuwen , Zhao Lina 
Published: July 2023

Abstract
Nasopharyngeal carcinoma (NPC) is one of the most ordinary malignant tumors. Current research has suggested that circular RNAs play an important role in tumor genesis and progression. The purpose of this study is to explore the function and underlying mechanisms of circ_0028007 in NPC. The levels of circ_0028007, miR-1179, and Squalene epoxidase (SQLE) were detected by quantitative real-time polymerase chain reaction. Cell proliferation was detected by colony formation assay and thymidine analog 5-ethynyl-2′-deoxyuridine assay. Cell apoptosis was detected by flow cytometry. Relevant kits detected caspase-3, glucose, and lactate levels. Western blot assay was used to detect the related protein content. Dual-luciferase reporter assay and RNA pull-down assay were used to examine the target relationship between miR-1179 and circ_0028007 or SQLE. circ_0028007 and SQLE were highly expressed in NPC, while miR-1179 was lowly expressed. circ_0028007 silencing inhibited NPC cell proliferation and promoted apoptosis. However, the effect of circ_0028007 down-regulation on NPC cells was partially restored by co-transfection with miR-1179 inhibitor. Overexpression of SQLE partially restored the cell proliferation inhibited by circ_0028007 knockdown. circ_0028007 could regulate NPC progression via the miR-1179/SQLE axis. Therefore, circ_0028007 might be a new therapeutic target for NPC.
Effects of pharmacological delay with roxadustat on multi-territory perforator flap survival in rats
Authors: Tao Xianyao , Pan Xiaoyun , Rui Yongjun , Xue Mingyu 
Published: July 2023

Abstract
Roxadustat (FG-4592) is a specific hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitor. We investigated the effects of FG-4592 pretreatment on survival and second choke vessels of multi-territory perforator flaps in rats. In total, 72 rats were divided into two groups (n = 36 each): the experimental (FG-4592) group and the control group. FG-4592 was administered orally as a single dose of 60 mg/kg every other day; the first drug solution was administered to the animals 7 days before the surgical procedure. On postoperative day 7, the surviving flap area was calculated. At 12 h post-surgery, in the second choke zone in the flaps, macrovascular hinges were compared by angiography and imaging, and microvascular changes were assessed by histology. Laser Doppler imaging was used to evaluate flap perfusion at the second choke zone at 12 h and 7 days after surgery. At 7 days after surgery, the flap survival area and perfusion were significantly greater in rats given FG-4592 compared with controls. At 12 h after surgery, the diameter of macrovascular and microvascular vessels, nitric oxide content, perfusion, and the protein levels of HIF-1α and inducible nitric oxide synthase were also significantly greater in FG-4592-treated rats than controls. In conclusion, pretreatment with roxadustat may improve initial flap survival and dilate the second choke zone vessels in a multi-territory perforator flap.
Noncontractible loop states from a partially flat band in a photonic borophene lattice
Authors: Menz Philip , Hanafi Haissam , Imbrock Jörg , Denz Cornelia 
Published: July 2023

Abstract
Flat band systems are commonly associated with compact localized states (CLSs) that arise from the macroscopic degeneracy of eigenstates at the flat band energy. However, in the case of singular flat bands, conventional localized flat band states are incomplete, leading to the existence of noncontractible loop states (NLSs) with nontrivial real-space topology. In this study, we experimentally and analytically demonstrate the existence of NLSs in a 2D photonic borophene lattice without a CLS counterpart, owing to a band that is flat only along high-symmetry lines and dispersive along others. Our findings challenge the conventional notion that NLSs are necessarily linked to robust boundary modes due to a bulk-boundary correspondence. Protected by the band flatness that originates from band touching, NLSs play a significant role in investigating the fundamental physics of flat band systems.
Room-temperature unidirectional routing of valley excitons of monolayer WSe2 via plasmonic near-field interference in symmetric nano-slits
Authors: Wen Xinglin , Zhou Yunxi , Chen Sijie , Yao Wendian , Li Dehui 
Published: July 2023

Abstract
Due to the short valley polarization time, it is hardly to separate opposite valley pseudospin of transition metal dichalcogenides (TMDs) for their practical applications in valleytronics. Coupling TMDs to unidirectional surface plasmon polariton (SPP) can overcome this obstacle. However, it is required to break the symmetry to induce the asymmetric coupling between valley exciton dipole and SPP to route valley exciton in previously proposed strategies. Herein, by utilizing a new mechanism that near-field interference can create directional SPP in symmetric nanostructures, we realize directional routing of valley exciton emission of monolayer WSe2 at room temperature with a symmetric nano-slits array. The near-field interference enabled directional SPP in our device not only render the exciton diffusion length increase from 0.9 to 3.0 μm, but also lead to a valley exciton separation length of 0.7 μm with degree of valley polarization up to 22 %. This valley excitons separation is attributed to the non-flat WSe2 in the nano-slits region, which makes the exciton dipoles present in-plane and out-of-plane simultaneously. Our work provides a convenient and promising strategy towards room temperature on-chip integrated valleytronic devices.
Antimicrobially effective protein-loaded metal chelated chitosan composite
Authors: Akkaya Birnur , Akkaya Recep , Taşkın Kafa Ayşe Hümeyra 
Published: July 2023

Abstract
The immobilization of lysozyme onto a novel synthetic metal chelator composite based on chitosan/PAA-PMA (chitosan/acrylamide-maleic acid) and its effect on antimicrobial activity were the aim of the current study. The plain composite and the lysozyme immobilized composite were characterized according to scanning electron microscopy (SEM), Ultraviolet spectroscopy (UV), Fourier transform infrared (FT-IR), and X-ray diffraction (XRD) analysis. Furthermore, the activities of lysozyme and immobilized lysozyme were investigated, as well as their antimicrobial activity against Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Enterococcus faecalis, and Staphylococcus aureus, as well as their cytotoxic effects, which were both approximately greater than those of free lysozyme. The last step was cytotoxic studies on lysozyme, chitosan composite, and lysozyme-immobilized chitosan composite, which showed no cytotoxic effect. Several investigations have shown that metal chelators improve lysozyme’s antibacterial action. Two carboxylic acids containing maleic acid were used as a metal chelator in this study. Lysozyme was immobilized from a side other than carboxylic acids, so that carboxylic acid groups, which are metal chelating groups, do not prevent synergy by competing with metal binding at neutral pH. This enhanced antimicrobial activity.
Vom Alleinautor zum gemischten Doppel? Geschlecht, Status und Sichtbarkeit in der Publikationspraxis führender deutscher Soziologiezeitschriften
Authors: Trappe Heike , Milewski Nadja 
Published: July 2023

ZusammenfassungDieser Beitrag analysiert die Publikationspraxis der Zeitschrift für Soziologie und der Kölner Zeitschrift für Soziologie und Sozialpsychologie unter Berücksichtigung geschlechtstypischer Entwicklungen seit Mitte der 1990er Jahre. Hintergrund ist die Veränderung des sozialwissenschaftlichen Publizierens, die parallel zu einer Zunahme des Frauenanteils in den Sozialwissenschaften stattgefunden hat. Ausgehend von Erklärungen der geschlechtsspezifischen Segregation in Organisationen beschreiben wir auf Basis eines selbst erstellten Datensatzes die Teilhabe von Frauen an der Publikation von Forschungsaufsätzen und Rezensionen sowie an Begutachtungen und Herausgebergremien. Trotz erheblicher Fortschritte in der Erhöhung ihrer Sichtbarkeit sind Frauen noch nicht entsprechend ihrem erwartbaren Anteil in allen Funktionsgruppen vertreten. Als Herausgeberinnen und als Autorinnen von Forschungsbeiträgen haben sie am stärksten aufgeholt, wobei sich bei letzteren Kooperationen mit Männern begünstigend ausgewirkt haben.
Ni3Sn4 and FeAl2 as vacancy variants of the W-type (“bcc”) structure
Authors: Leineweber Andreas 
Published: July 2023

Abstract
Systematization of the vast number of known crystal structures of intermetallic phases is a challenge. One previously proposed group is referred to here as vacancy variants of the W-type structure. Members of this group, may, however, not be easily recognized because of the structural irregularity introduced by the vacancies. Descriptions of the experimentally observed crystal structures of Ni3Sn4 and FeAl2 in terms of vacancy variants of the W-type structure are, respectively, derived by establishing a lattice correspondence with the W-type structure, allowing, in particular, identification of the vacant sites. In both cases only small deviatoric strains are required to obtain the experimentally encountered lattice parameters, and generally small atomic displacements occur from the ideal positions, thus demonstrating significance of the lattice correspondence. The lattice correspondences allow, for both Ni3Sn4 and FeAl2, relating reported microstructure evidence (directions/planes occurring in orientation relationships and crystal habits but also on twinning and slip) with such typical for metals and solid solutions with W-type (“bcc”) structures. This demonstrates that the established lattice correspondences have a significance going beyond a descriptive one, but the underlying W-type structures reveal themselves in the materials’ behavior.