bluuebunny/crossref_metadata_2025_split huggingface dataset:
The role of polymorphic markers of the <i>WWP2</i> and <i>GDF5</i> gene in the progression of gonarthrosis in the population of the Central Chernozem region of Russia
Authors: Novakov V. B. , Novakova O. N. , Churnosov M. I. 
Published: May 2023

Introduction. Osteoarthritis (OA) is one of the most common diseases of the musculoskeletal system, in the development and progression of which hereditary (genetic) factors play an important role. Aim. To establish the role of polymorphisms of candidate genes rs1060105 and rs56116847 SBNO1, rs6499244 NFAT5, rs34195470 WWP2, rs143384 GDF5 in the progression of knee OA in the population of the Central Chernozem region of Russia. Materials and methods. The sample for the study, including 500 patients with knee OA, was divided into two groups: group 1 – patients with stages 3–4 of the disease according to J. Kellgren – J. Lawrence (n = 325), group 2 – patients with stage 2 (n = 175). The study was carried out in a case-control design. Genotyping of DNA samples was performed using the polymerase chain reaction method of TaqMan probes. The study of associations of polymorphic genetic loci with the progression of gonarthrosis was carried out by the method of logistic regression, taking into account the corrections – age, sex, BMI.Results. The G/G genotype rs34195470 of the WWP2 gene (OR = 0.62, p = 0.029) has a protective role in the progression of the knee OA, the A/G genotype of the same polymorphism is a risk factor for disease progression (OR = 1.65, p = 0.012). Within the framework of the dominant genetic model, significant associations with the progression of gonarthrosis were established for the allele A rs34195470 of the WWP2 gene (OR = 1.61, p = 0.039, pperm = 0.049) and the allele variant G rs143384 of the GDF 5 gene (OR = 0.59, p = 0.024, pperm = 0.024).Conclusion. Genetic risk factors for the development of OA of the knee joint of 3–4 radiographic stages are the allele A and the hepotype A/G rs34195470 of the WWP2 gene. The genotype G/G rs34195470 of the WWP2 gene and the allele G rs143384 of the GDF5 gene are of protective importance in the progression of the disease in the population of the Central Chernozem Region of the Russian Federation.
Rehabilitation treatment of patients with stable angina with long-term complex use of physiotherapy methods
Authors: Kasparov E. V. , Razumov A. N. , Klemenkov S. V. , Klemenkov A. S. , Kubushko I. V. 
Published: May 2023

Introduction. The high morbidity and mortality from heart disease determines the relevance of improving the methods of treatment and rehabilitation for this pathology. However, many issues of long-term complex use of balneohydrotherapy and preformed physical factors in this disease have not been studied enough. Aim. To study the possibilities of long-term complex use of general fresh baths and amplipulse therapy in the rehabilitation treatment of patients with coronary heart disease with stable angina. functional class II. Materials and methods. A prospective single-center controlled randomized study was carried out. 107 people were under observation: male patients with CHD with stable angina pectoris FC II, disease duration from 5 to 10 years. The study participants were divided into three age-matched groups (mean age 50 ± 2 years): 1) were prescribed fresh baths and amplipulse therapy (effect on the heart area) according to the generally accepted method, while physical factors were prescribed every other day, and the duration of treatment was 1 month; 2) were prescribed fresh baths and amplipulse therapy according to the same method for a duration of treatment of 3 months; 3) control – fresh baths and therapeutic exercises were prescribed for 1 month. Rehabilitation was carried out against the background of drug therapy. The evaluation of the results was carried out by functional methods: 24-hour Holter ECG monitoring, spiroergometry, exercise test. Results. Analysis of the results of the exercise test (bicycle ergometry, spiroergometry) showed that long-term complex use of fresh baths and amplipulse therapy in CHD patients provided a more pronounced training effect and an increase in the coronary heart reserve than a monthly course of fresh baths and amplipulse therapy or fresh baths and therapeutic exercises. The training effect of long-term complex use of fresh baths and amplipulse therapy leads to an increase in the level of physical performance, coronary reserve of the heart, a decrease in myocardial ischemia and an average number of ventricular (1-3 class according to B. Lown) and supraventricular arrhythmias (extrasystoles) per day. 24-hour Holter ECG monitoring confirms these data. Conclusion. Long-term complex use of fresh baths and amplipulse therapy allows to increase the efficiency of rehabilitation treatment in CHD patients.
A clinical case of successful thrombolysis in pulmonary embolism during pregnancy
Authors: Andreeva A. V. , Danilov A. V. , Devyatova L. S. , Moseichuk K. A. , Filippov E. V. 
Published: May 2023

The risk of venous thromboembolic complications among pregnant women and puerperas is higher than in the general population, which is due to traditional risk factors, as well as physiological and anatomical changes that occur during pregnancy. Symptoms and signs of venous thromboembolic complications during pregnancy are often nonspecific and may coincide with the consequences of changes, including dyspnea, limb edema, and tachycardia. D-dimer levels may be elevated during ongoing pregnancy, limiting its use as a laboratory marker. Identification of the source of thromboembolism in the veins of the lower extremities can be difficult due to the proximal localization of thrombosis in pregnant women, the rare detection of thrombi in this area is associated with incompressibility of the veins due to their intrapelvic location, as well as with altered blood flow mechanics. The main method of treatment is the use of low molecular weight heparins, however, in case of massive thromboembolism, leading to hemodynamic instability and a high risk of mortality, thrombolytic therapy is indicated. Thrombolytic therapy is associated with an increased risk of hemorrhagic complications. The use of warfarin and direct oral anticoagulants during pregnancy is contraindicated due to the possibility of penetration of drugs through the placental barrier. The article presents a clinical case of successful thrombolysis in a patient with pulmonary embolism in late pregnancy. The chosen tactics of management corresponded to the clinical guidelines and made it possible to successfully treat pulmonary embolism without complications for the mother and fetus. Drugs were used that do not penetrate the placental barrier and do not have teratogenic effects.
The role of hereditary thrombophilia in the development of venous thrombosis in combat trauma
Authors: Salukhov V. V. , Gavrilov E. K. , Varavin N. A. , Kapustin S. I. , Bardakova D. A. 
Published: May 2023

Introduction. Combat trauma is one of the factors causing hemostasis disorders in the wounded. Currently, there is insufficient information about the significance of hereditary thrombophilia in the development of venous thromboembolic complications in the wounded.Aim. To study the effect of polymorphism of genes of components of the hemostasis system on the development of venous thrombosis in wounded with combat trauma.Materials and methods. The prospective study included men (n = 81) of young age (the average age was 36.0 ± 8.5 years) who received a combat wound and were treated at the Military Medical Academy named after S.M. Kirov. The subjects were divided into 2 groups: the main group included 40 victims (49.4%) who were diagnosed with venous thrombosis during treatment, the control group included 41 patients without signs of thrombosis (50.6%). The study of allelic polymorphism of genes associated with the formation of blood clots was carried out using a real-time polymerase chain reaction based on the study of human DNA in peripheral blood material.Results. Comparative analysis revealed no statistically significant differences in the frequency of occurrence of the studied genetic variants between the study group and the control group. When assessing the prevalence of polymorphism of the MTHFR and MTRR genes, it was found that the combination of the genotypes “MTHFR 677 CT” and “MTRR 66 GG” is associated with an 8.5-fold increase in the risk of developing VTEO [OR = 8.5; p = 0.029].Conclusion. Analysis of the test results showed that no relationship was found between individual genetic variants and the risk of developing venous thrombosis in the studied group of wounded despite the high prevalence (prothrombogenic alleles of various genes were detected in 79 servicemen (97.5%)). At the same time, the combination of MTHFR 677 CT and MTRR 66 GG genotypes in that patient population was shown to be associated with a significant increase in the risk of thrombosis.
Improvement of personnel management of internal affairs bodies on the basis of system analysis procedures
Authors: Rybak A. V. , Danilov R. M. 
Published: May 2023

Objective. The purpose of the study is to identify the main causes of the growing shortage of personnel resources of territorial divisions of internal affairs bodies (ATS) and appropriate methods of their elimination.Method. When searching for the causes of the personnel shortage of the ATS, the procedures of system analysis were used, on the basis of which the central problem of the staffing of the ATS was identified, a number of tasks and goals were formulated, for the solution of which additional material resources are not required. Mathematical methods of system dynamics were used to solve most problems.Result. In the work, based on the analysis of the operational situation, regulatory and methodological support of the management activities of the internal affairs bodies, it is concluded that there is a systemic problem: the dynamism of the management system of the internal affairs bodies is disrupted, as a result of which the effectiveness of the management process decreases, leading to an increasing trend of a shortage of ATS units. To solve the identified problems, the authors propose the following technologies: calculation of the profitability of the work of territorial divisions of the Ministry of Internal Affairs of Russia, which allows to assess the necessary and sufficient level of efficiency of the use of all types of resources in the performance of official tasks; development of a methodology for calculating the personnel needs of territorial divisions of the Ministry of Internal Affairs of Russia, taking into account the complexity of their activities, workload and regional characteristics; introduction of a new approach to assessing the activities of divisions The Ministry of Internal Affairs of Russia, based on the separation of the reporting system and the evaluation system, improving personnel policy in terms of making the service in the Department of Internal Affairs more attractive, taking into account the new values of modern society. For each presented task, its own tools and solution technology have been developed.Conclusion. The solution of the identified tasks will ensure the uniformity and "feasibility" of the workload of its employees, the transparency of the assessment of their activities, which will increase the motivation for conscientious work. Coupled with the improvement of personnel policy to make the service in the internal affairs bodies properly attractive, the expected synergetic effect will reduce the severity of the problem of personnel shortage.
Investigation of liquid fuel combustion processes in an electrostatic fieldе
Authors: Mukanov R. V. , Alyautdinova Yu. A. , Strelkov S. P. 
Published: May 2023

Objective. The article presents the results of experimental studies on the effect of a high-potential electrostatic field on the combustion of liquid fuel. Method. Experimental studies were carried out on the developed laboratory installation, which makes it possible to ensure the combustion of liquid fuel in a high-potential electrostatic field with the possibility of changing the polarity. The change in the polarity of the applied voltage to the electrode system of the experimental setup led to an increase in the fuel burning rate in the first case, and to its attenuation in the second.Result. In this paper, studies have been carried out proving the effect of an electrostatic field on the burning rate and reducing the content of harmful components (soot and carbon monoxide) in fuel combustion purges. Based on the values of the fuel burning rate obtained as a result of the experiments, graphic dependences were constructed on the applied voltage, on which the areas of linear and non-linear changes in the combustion parameters were identified.Conclusion. The results of the research carried out can be used to create new highly efficient burners for liquid fuel boilers. The effect of reducing the burning rate can be used to create fire safety devices that block the spread of flame during a fire.
To the issue of optimising the performance of a scroll compressor as part of a CO2 booster refrigerating machine in order to increase its efficiency
Authors: Pronin V. A. , Kovanov A. V. , Tsvetkov V. A. , Mikhailova E. N. , Belov P. A. 
Published: May 2023

Objective. With the decreasing use of refrigerants with a high global warming potential, increasing the efficiency of refrigeration machines using natural working fluids is a very urgent task. The CO2 booster refrigerant cycle may be optimal for the fields of commercial refrigeration, climate engineering and heat pumps, but needs to be adapted to regions with hot climates. The purpose of the study is also to systematize possible ways to improve the spiral technology, as a guarantee of increasing the efficiency of booster refrigeration machines.Method. Such solutions have already been tested by increasing the transcritical cycle efficiency through the use of an ejector and parallel compression. However, the use of a scroll compressor in the transcritical cycle may be a good alternative to these methods. This solution, a little bit improves technical and economic indexes of the refrigerating machine, in the most part reducing capital and operational costs. When considering the prospect of improving the efficiency of a booster system with scroll compressor, it is necessary to address the issue of compressor performance optimisation. An issue of this kind can be referred to improving the efficiency of the booster system, at the expense of the internal characteristics of the refrigeration machine.Result. Thus, in this paper, a conceptual approach is considered to solve this problem based on a system analysis of the interconnection of the compressor as the main energy-intensive element of a refrigeration machine.Conclusion. Development of conceptual model, allows to identify influence of various factors on scroll compressor operation and to build adequate mathematical model, to choose or develop necessary calculation methods.
Impact of Cultural and Linguistic Maintenance on Mental Health Outcomes in Migrant Adolescents: Protocol for a Scoping Review
Authors: Hasnain Anila , Hajek John , Borschmann Rohan 
Published: May 2023

Background
There is no consensus on how the disruption or maintenance of heritage culture and language affect mental health outcomes in adolescents with a migrant (also known as “immigrant” or “international migrant”) background. Even though previous literature reviews have investigated the association between acculturation and mental health in migrants, none have explicitly focused on adolescents.

Objective
The aim of the scoping review described in this protocol is to understand (1) the focus, scope, and nature of quantitative empirical research investigating heritage cultural maintenance, including linguistic maintenance, and mental health outcomes in adolescents with a migrant background worldwide and (2) the potential effects of cultural and linguistic maintenance or disruption on migrant adolescent mental health outcomes.

Methods
A total of 11 key electronic health, medical, social science, and language databases (APA PsycArticles Full Text; Embase Classic+Embase; Ovid MEDLINE All and Epub Ahead of Print, In-Process, In-Data-Review and Other Non-Indexed Citations and Daily; Ovid MEDLINE All; APA PsycInfo; University of Melbourne full-text journals; Science Citation Index Expanded; Social Sciences Citation Index; Arts & Humanities Citation Index; Scopus; Linguistics and Language Behavior Abstracts) were searched. Databases were searched without time restrictions from the beginning of their coverage. Publication date, location, and quantitative study design (except for literature reviews) were not restricted; however, the search was only conducted in English. Data from included studies will be extracted using a template with predefined data items, and results will be summarized in a structured, narrative summary.

Results
A search was conducted on April 20, 2021, returning 2569 results. We are currently at the final stages of screening titles and abstracts of our search results, which will be followed by a full-text review and the data extraction of included studies. We expect to submit the full review for publication by the end of 2023.

Conclusions
The scoping review aims to provide a better understanding of existing research on the association between cultural (including linguistic) maintenance and mental health in migrant adolescents. It will help identify gaps in the existing literature and develop hypotheses that could inform future research, eventually facilitating the development of targeted prevention initiatives and improving migrant adolescents’ well-being.

International Registered Report Identifier (IRRID)
DERR1-10.2196/40143
Politik Etnik dan Kekeluargaan Sebagai Sumber Perilaku Politik Masyarakat Pedesaan di Barito Selatan
Authors: Hadi Kisno 
Published: May 2023

Tulisan ini mendeskripsi tentang perilaku politik yang berwujud sikap politik masyarakat pedesaan di pedalaman Kalimantan Tengah. Tulisan ini diangkat dari hasil penelitian saat Pemilu legislatif 2019 dan Pilkada Kalteng 2020. Penelitian menggunakan metode kualitatif interpretatif, dengan pengumpulan data lapangan melalui pengamatan langsung di mana penulis berada di lapangan saat pelaksanaan Pemilu 2019 dan PILKADA Gubernur Kalteng 2020, wawancaradengan Mantir Adat (tokoh adat), dan analisis data pustaka berupa buku, jurnal dan data KPU Barito Selatan. Penelitian ini mendeskripsi dua hal, Pertama, fenomena afiliasi politik masyarakat pedesaan di Kabupaten Barito Selatan sebagai pengaruh budaya politik masyarakatsuku Dayak yang hidup dan berkembang dalam suasana masyarakat pedesaan-pedalaman; Kedua, fakta perilaku politik masyarakat pedesaan di Kabupaten Barito Selatan dalam politik elektoral Pemilu 2019 dan Pilkada 2020. Temuan penelitian ialah Pertama, tidak terjadi pergeseran afiliasi politik sejak tahun 1950an sampai saat ini, di mana afiliasi politik masyarakat pedesaan tidak beranjak dari afiliasi etnis; Kedua, afiliasi etnis diperankan sebagai penyeimbang kekuatan politik lain dari luar seperti dominasi etnis lain dan sebagai upaya perlindungan sosial mereka kepada kekayaan sumber daya alam di desa; dan Ketiga, sikap politik dipraktikkan dengan cara mereka sendiri yang khas, yakni personal approach (pengenalan personal),ethnicity (etnisitas dan kekeluargaan), dan opennes and honesty (keterbukaan dan kejujuran).
Peran “Sintalitas” dalam Optimalisasi Pemanfaatan Teknologi Pertanian Padi pada Kelompok Tani Sedyo Luhur di Boyolali
Authors: Wibowo Dina Sulistyo , Wahyuni Hermin Indah , Wati Ratih Ineke 
Published: May 2023

Latar belakang penelitian adalah terdapat pengadaan alat dan mesin pertanian (alsintan) olehpemerintah, tetapi pemanfaatannya tidak efektif. Pemerintah juga menggelar sosialisasi UPJA, tetapi belum tumbuh di setiap kelompok tani (poktan). Masalah penelitian adalah tentang sintalitas Poktan Sedyo Luhur dalam optimalisasi pemanfaatan mesin tanam bibit padi.Penelitian ini bertujuan untuk menganalisis sintalitas Poktan Sedyo Luhur dalam optimalisasi pemanfaatan mesin tanam bibit padi. Metode yang digunakan adalah deskriptif secara kualitatif. Lokasi penelitian di Poktan Sedyo Luhur yang berlokasi di Desa Dibal Kecamatan Ngemplak Kabupaten Boyolali. Hasil penelitian menunjukkan bahwa Poktan Sedyo Luhur memiliki sintalitas dalam optimalisasi pemanfaatan mesin tanam bibit padi yang ditunjukkan melalui sifat sintalitas, sifat struktur, dan sifat populasinya. Sifat sintalitas ditunjukkan oleh Poktan Sedyo Luhur yang memiliki pengaruh baik bagi individu anggota maupun anggota bagian dari poktan dan poktan menjalin kerja sama dengan berbagai mitra dalam pengoptimalan pemanfaatan mesin tanam bibit padinya, tetapi jalinannya kurang baik dengan dinas pertanian. Sifat struktur poktan ditunjukkan oleh keberadaan seksi alsintan yang mengelola alsintan bertaraf UPJA dengan 75 persen anggota berperan dalam memanfaatkan alsintan tersebut. Poktan Sedyo Luhur juga mengelola mesin tanam bibit padinya yang disertai dengan batasan norma-norma. Sifat populasi poktan ditunjukkan oleh mayoritas anggota memiliki umur di atas 40 tahun dengan pekerjaan lain di luar pertanian. Poktan Sedyo Luhur harus meningkatkan hubungannya dengan dinas pertanian dan juga meregenerasi anggotanya.
The Factors of Rice Farmers’ Poverty in Indonesia: The Perspective of Land Conversion, Land Ownership Area, and Agriculture Technologi
Authors: Widyanto Septian , Subanu Leksono Probo 
Published: May 2023

Rice is very important as Indonesia’s main staple. It contributes a lot to the national expenditure where more than 80% of households of every social class consumed rice. There is a high demand level for rice but there is a limited number of farmers. Of 70% of households in rural that work in the agricultural sector, only 50% grow rice, and most of them are poor farmers. Almost 52% of Indonesia’s rice is produced at Java Isle. However, production growth is only 0,7% given the rapidly increasing number of people and land conversion over the past 7 years. Most Indonesian farmers are classified as small farmers has average land ownership of only less than 0.5 hectares, making them can’t innovate and only can fulfil their basic needs without saving for investment. This is made worse by around 35% of farmers don’t own their land. Technology usage also become an issue where 85% of farmers don’t use internet and 45% are not used in using mechanical technology. The purpose of this research is to find the effect of paddy land conversion, land ownership area, and agriculture technology on farmer’s poverty in Indonesia. By using multiple regression method on 6 independent variables data from all Indonesia provinces, we found that the most significant variable to reduce farmer’s poverty is land ownership area. The statistical result is supported and cross-checked by data and related policies from literature review, and interview with some stakeholders from Ministry of Agriculture, local government, paddy farmer representative, and agriculture instructor.