bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interaksi Genotipe dan Lingkungan terhadap Ukuran Karakter Ubijalar Lokal Papua Berdasarkan Analisis AMMI
Authors: Mustamu Yohanis Amos , Prabawardani Saraswati , Kurni Otties 
Published: February 2023

<p>Penelitian ini bertujuan untuk memperoleh informasi pengaruh interaksi genotipe dengan lingkungan terhadap penampilan genotipe ubijalar unggul lokal Papua berdasarkan karakter ubi ekonomi dan menduga genotipe ubijalar lokal Papua yang memiliki daya adaptasi luas berdasarkan karakter ekonomi. Penelitian ini dilaksanakan di tiga lokasi yaitu di Kabupaten Manokwari, Kabupaten Biak Numfor, dan Kabuapten Supiori pada bulan Juli 2020 sampai bulan Desember 2020. Sebanyak 12 genotipe ubijalar unggul lokal lokal Papua yaitu Amban Pantai, Arfai, SP5, Kaimana2, Oransbari, Abepura, Koya1, Koya3, Koya5, Koya6, Koya7, dan Koya8. Berdasarkan hasil penelitian interaksi genotipe-lingkungan dan stabilitas untuk jumlah ubi ekonomi dan bobot ubi ekonomi dapat disimpulkan analisis ragam gabungan menunjukkan pengaruh yang nyata (p &lt;0,01) untuk genotipe, dan interaksi genotipe dan lingkungan. Hasil analisis AMMI menunjukkan genotipe yang stabil berdasarkan karater jumlah ubi ekonomi adalah SP5, Koya1 dan Koya3, sedangkan genotipe yang stabil berdasarkan karakter bobot ubi ekonomi adalah SP5, Abepura, Koya1, Koya3, Koya5, dan Koya7. <br /><br /></p>
A Method for Determination of Rock Fabric Number from Well Logs in Unconventional Tight Oil Carbonates
Authors: Azuara Diliegros Brenda , Aguilera Roberto 
Published: February 2023

Summary
This paper develops a method for estimation of rock fabric number (RFN) from well logs in unconventional tight oil carbonates with permeability less than 0.1 md. The objective is to investigate the oil potential of a Middle Cretaceous tight carbonate in Mexico. The development of a method for these conditions is challenging as the current approach developed by Lucia (1983) has been explained for carbonates with permeability more than 0.1 md.
Core data and drill cuttings available for this study are limited but provide important insights for the log interpretation and for identifying the presence of grainstone, packstone, and wackstone rocks in the unconventional tight carbonate under consideration. A crossplot of RFN vs. rp35 (pore throat radius at 35% cumulative pore volume) permits delimiting intervals with good production potential that are supported by well testing data. Information for the analysis of the Mexican carbonate comes from well logs of nine wells and two re-entry wells, four buildup tests, and a limited amount of core and drill cuttings information. All data were provided by a petroleum company and have been used, for transparency, without any modifications.
An unconventional tight carbonate as defined in this paper has a permeability smaller than 0.1 md. The unconventional tight oil carbonate reservoir considered in this study includes 95% of data with permeabilities smaller than 0.1 md and only 5% with permeabilities larger than 0.1 md. The method introduced by Lucia (1983) and Jennings and Lucia (2003) for determining RFN is powerful, but they explained it only for permeabilities larger than 0.1 md, thus the need for a methodology that allows estimating from well logs the presence of grainstone, packstone, and/or wackstone in unconventional tight carbonate reservoirs with permeabilities smaller than 0.1 md.
Results indicate that the RFN provides a useful approach for distinguishing grainstone, packstone, and wackstone rocks in unconventional tight carbonate reservoirs. Furthermore, rock fabric can be linked with Pickett plots to provide an integrated quantitative evaluation of RFN, porosity, water saturation, permeability, pore throat radius, and capillary pressure. This integration indicates that there is good oil potential in the Middle Cretaceous unconventional tight carbonate in Mexico.
Deep Learning Methods for Improving Electromagnetic Telemetry Signal-to-Noise Ratio
Authors: Urdaneta C. , Jarrot A. , Wang S. , Wu X. , Chen J. 
Published: February 2023

Summary
Electromagnetic (EM) telemetry is a cost-competitive method for communication between downhole tools and oilfield surface equipment. However, EM telemetry use is limited to wellsite deployments that result in favorable signal-to-noise ratio (SNR) levels. Increasingly, the EM attenuation brought by deeper wells, conductive service fluids, and conductive formation layers has made it more important to increase EM telemetry SNR. This study explored the ability of various deep learning (DL) methods to improve EM telemetry SNR with data sets composed of mixed synthetic downhole signals and real field noise. The DL models explored were previously proven to achieve state-of-the-art performance with seismic random noise attenuation and speech separation use cases.
Furthermore, architectural adjustments that improved model performance with EM telemetry data were targeted. Then, the SNR improvement performance of different design changes was evaluated. Finally, the study targeted improvements that reduced the requirements for deployment hardware, including number of stakes, without sacrificing SNR improvement performance. Optimized models were found to successfully improve SNR in EM telemetry data, outperforming traditional bandpass filter methods and enabling the demodulation of mixtures that were otherwise too noisy to be demodulated.
Transit of electric currents in the human nervous system: hypothesis
Authors: Neto Arnaldo Pinto Guedes de Paiva 
Published: February 2023

Abstract
A review of the literature on the action potential was performed. The article consists of a hypothesis about the types of energy generated by the action potential. The objective is to determine the transit of energy generated in the nervous system. Libet established that human beings take about 0.5 second to become aware of a sensory stimulus. This is the time threshold to elicit any conscious sensation. The electrical current threshold is 2 mA. The wave amplitude threshold is 50 µV. The action potential generates a variation of energy obtained that can be compared to the act of starting a car. This first energy variation can be called “ignition Δi”. From 0.5 second until the memory´s formation of a stimulus that occurred, there is a variation of electrical current. This variation can be called “effective Δi”. There is a moment when this variation of ignition energy becomes a constant electric current or “residual current”. When the pulse repetition frequency is doubled, the ignition Δi increased by 12.39%, the effective Δi increased by 21.80%, and the residual i decreased by 52.39%. Higher pulse rates allow less energy to be dissipated and higher wattage. The sum of effective Δi relates to short-term memory.
High spontaneous integration rates of end-modified linear DNAs upon mammalian cell transfection
Authors: Lim Samuel , Yocum R. Rogers , Silver Pamela A , Way Jeffrey C 
Published: February 2023

Abstract
In gene therapy, potential integration of therapeutic transgene into host cell genomes is a serious risk that can lead to insertional mutagenesis and tumorigenesis. Viral vectors are often used as the gene delivery vehicle, but they are prone to undergoing integration events. More recently, non-viral delivery of linear DNAs having modified geometry such as closed-end linear duplex DNA (CELiD) have shown promise as an alternative, due to prolonged transgene expression and less cytotoxicity. However, whether such modified-end linear DNAs can also provide a safe, non-integrating gene transfer remains unanswered. Herein, we provide a systematic comparison of genomic integration frequency upon transfection of cells with expression vectors in the forms of circular plasmid, unmodified linear DNA, CELiD, and Streptavidin-conjugated blocked-end linear DNA. All of these forms of linear DNA resulted in a high fraction of the cells being stably transfected – between 10% and 20% of the initially transfected cells, with CELiDs showing the highest rates of integration. These results indicate that blocking the ends of linear DNA is insufficient to prevent integration. Moreover, our analysis suggest that conventional AAV-based gene therapy may be highly susceptible to integration, which is consistent with recent findings from long-term clinical studies.
Prevention of M2 polarization and temporal limitation of differentiation in monocytes by extracellular ATP
Authors: Scherr Benedikt F. , Reiner Martin F. , Baumann Flavia , Höhne Kerstin , Müller Tobias , Ayata Korcan , Müller-Quernheim Joachim , Idzko Marco , Zissel Gernot 
Published: February 2023

Abstract
Background: Increased extracellular adenosine triphosphate-levels modulate immunologic pathways and are considered a danger signal in inflammation, lung fibrosis and cancer. M1 macrophages are classically activated, pro-inflammatory macrophages, whereas M2 macrophages are alternatively activated, pro-fibrotic macrophages. We investigated the effect of ATP (adenosine triphosphate) on differentiation of native human monocytes. M1 and M2 like macrophages were characterized by the release of IL-1β (Interleukin-1beta) and CCL18 (Chemokine (C-C motif) ligand 18), respectively.
Results: Monocytes were stimulated with ATP, the P2X7 receptor agonist Benzoylbenzoyl-ATP and the expression of various purinergic receptors was analyzed. During 72h of cell culture, monocytes spontaneously differentiated to M2 like macrophages indicated by an increased release of CCL18. Immediate stimulation of monocytes with ATP dose-dependently reduced CCL18 release but did not affect IL-1β supernatant concentration. In contrast, delayed stimulation with ATP neither affected CCL18, nor IL-1β release. Similar results were observed in a model of inflammation using lipopolysaccharide-stimulated native human monocytes. Stimulation with the P2X7 receptor agonist BzATP (Benzoylbenzoyl-ATP) mimicked the effect of ATP on M2-macrophage differentiation suggesting that P2X7 is involved in ATP-induced inhibition of CCL18 release. Indeed, P2X7 was downregulated during spontaneous M2 differentiation, which may in part explain the ineffectiveness of late stimulation of monocytes with ATP. However, pre-incubation of monocytes with PPADS, Suramin (unselective P2X- and P2Y-receptor blockers) and KN62 (P2X7-antagonist) did not reverse the reduction of CCL18 by ATP.
Conclusions: ATP dose- and time-dependently prevented spontaneous differentiation of monocytes to M2-like-macropages and that the effects were mediated independent of P2X- and P2Y-receptors.
Regio- and Enantioselective CuH-Catalyzed 1,2- and 1,4-Hydrosilylation of 1,3-Enynes
Authors: Wang Zi-Lu , Li Qi , Yang Meng-Wei , Song Zhao-Xin , Xiao Zhen-Yu , Ma Wei-Wei , Zhao Jin-Bo , Xu Yun-He 
Published: February 2023

AbstractWe report a copper-catalyzed ligand-controlled selective 1,2- and 1,4-hydrosilylation of 1,3-enynes, which furnishes enantiomerically enriched propargyl- and 1,2-allenylsilane products in high yields with excellent enantioselectivities (up to 99% ee). This reaction proceeds under mild conditions, shows broad substrate scope for both 1,3-enynes and trihydrosilanes, and displays excellent regioselectivities. Mechanistic studies based on deuterium-labeling reactions and density functional theory (DFT) calculations suggest that allenylcopper is the dominant reactive intermediate under both 1,2- and 1,4-hydrosilylation conditions, and it undergoes metathesis with silanesviaselective four-membered or six-membered transition state, depending on the nature of the ligand. The weak interactions between the ligands and the reacting partners are found to be the key controlling factor for the observed regioselectivity switch.
Impact of mass drug treatment with albendazole and ivermectin on transmission of Wuchereria Bancrofti lymphatic filariasis in Burkina Faso from 2001 to 2017
Authors: SAWADOGO Abdoulaye , Ouédraogo/Sondo Apolline , Diallo Ismaêl , Kouakou Affoué Gisèle , Ouédraogo Gafourou Arsène , Tassembedo Mahamadi , Kima appolinaire , Sermé Mamadou , Ouédraogo Boukary , Tanon Koffi Aristophane , Eholié Serge Paul 
Published: February 2023

Abstract
Background
Lymphatic filariasis or bancroftosis is a neglected tropical parasitic disease that the world has resolved to eliminate by 2020. From 2001 to 2017, Burkina Faso has initiated a program to eliminate the disease. The objective of this study is then to describe the impact of annual mass drug administration (MDA) with ivermectin and albendazole on the transmission of lymphatic filariasis.
Methods
This was a descriptive ecological observational study that took place from January 1st to 31st December 2017 and covered the period from 2001 to 2017. All health districts implementing MDA with ivermectin and albendazole in Burkina Faso were included in the survey. Data related to treatment and transmission assessment surveys were collected and analyzed using STATA version 15. QGIS software version 2.18.25 was used to create the maps.
Results
During the 16 years of the program’s implementation, the geographic coverage of health districts was entirely completed (100%).
The average treatment coverage rate was 80%. Microfilaremia was less than 1% in 21 of the 30 sentinel sites. Continuing endemic sites had a higher prevalence of filarial antigen and initial microfilaremia. Post-treatment surveillance showed a prevalence of filarial antigen of 0.28% at 2 years, 0.08% at 4 years and 0.02% at 6 years respectively.
Out of a total of 70 health districts that were endemic, 87% (61/70) interrupted transmission of lymphatic filariasis.
Conclusion
Filariasis transmission was interrupted in several health districts. Evaluations showed a significant decrease of immuno-parasitological indicators during the implementation of the program, but the country did not achieve the goal.
Resveratrol promotes the repair of spinal cord injury by modulating M1/M2 polarization via NF-κB and STAT3 signaling pathway
Authors: Xu Jian , Liu Jun , Wan Zhanghui , Guo Yongjie , Wang Xiaowei 
Published: February 2023

Abstract
Spinal cord injury (SCI) is a severe neurological disease which causes high disability rate. However, there is no effective treatment for SCI, and it is still great challenge for spinal surgeons. SCI can be divided into primary injury and secondary injury, and secondary injury plays dominant roles in SCI. Neuroinflammation is not only an important factor causing secondary SCI, but also a target of SCI treatment. Microglia, resident immune cells in spinal cord tissue, regulate neuroinflammation by polarizing. Resveratrol(RES)has been reported to exert anti-inflammatory effects in SCI, however, the specific mechanisms is still unclear. In this study, we identified that RES improving the functional recovery of spinal cord in mice through locomotion behaviors. Immunofluorescence staining showed that RES promoted axonal regeneration. In vivo and vitro, a series of experiments were exerted to verify its effects on facilitate shift from M1 to M2 polarization of microglia. Furthermore, as an agonist of SIRT1, we identified RES regulate polarization via NF-κB and STAT3 signaling pathway by western blot. Overall, our study demonstrated that RES is a promising treatment for SCI and further explored the underlying mechanisms in modulating neuroinflammation after SCI.
Accurate prediction of gestational diabetes mellitus via a novel transformer method
Authors: Wang Hui , Yao Ye , Zheng Jieying , Peng Danhong , Wu Jiansheng , Wang Jun 
Published: February 2023

Abstract
Diabetes is a common complication that happened in pregnant women, and it often leads to many serious consequences for fetuses and gravidas. Accurate diagnosis of gestational diabetes mellitus (GDM) is the key to providing prompt and precise treatment and disease management. The artificial intelligence-based method is currently the most commonly used auxiliary way for clinical medical diagnosis. However, as all we know, there is no report on the assistance of GDM diagnosis based on artificial intelligence till now. In this work, we collected the clinical samples of 1000 pregnant women from ZhongDa Hospital of Southeast University in Nanjing city, which involves 221 cases of GDM. Then, a matrix factorization method was used to fill up all missing values in the original data. Next, a random forest model was adopted to evaluate the importance of each feature dimension to aid in finding potential clinical markers for the GDM diagnosis. Finally, a novel transformer-based method called TF-GDM was proposed for predicting gestational diabetes mellitus accurately. The results show that our TF-GDM method achieves excellent performance, with the accuracy, precision, and recall of 0.93, 0.88, and 0.92, respectively, and also with the F1 score and AUC value of 0.90 and 0.94, respectively. The results demonstrate that our TF-GDM method is significantly better than classic machine learning-based and deep learning-based methods.
The Need for a Multidisciplinary Approach in Patients with Hip and Knee Osteoarthritis
Authors: Tomasevic Snezana , Cicovacki Saska , Popovic Dunja , Hanna Fahad 
Published: February 2023

Abstract
Background: Degenerative joint diseases (osteoarthritis) have considerable sociomedical importance due to their chronic nature, high frequency, demanding treatment and consequences they leave behind. The purpose of this study is to evaluate the relationship between knee/hip osteoarthritis and level of pain, depression and wellbeing.
Material and methods: The cross-sectional study included patients with hip or knee osteoarthritis receiving treatment at the Clinic for Medical Rehabilitation, Clinical Centre of Vojvodina in Novi Sad, Serbia. Two sets of questionnaires were administered in the study: BPI (Brief Pain Inventory) and Beck Depression Inventory (BDI).
Results: A total of 60 subjects participated in this study (48 with knee OA and 12 with hip OA). Mild pain was detected in 12 patients (20%), moderate pain in 39 patients (65%), while 9 patients (15%) had severe pain. A strong pain effects were observed in 16 patients (27%). In the sample, 42 (70%) patients experienced low-level depression, and 18 (30%) patients had high-level depression.
Conclusion: A high level of depression was found in 30% of patients with hip and knee OA. The pain effects on ADLs measured by BPI speak in favour of significant pain effects on ADLs in half of patients. Patients with a higher level of depression experience pain more intensely and encounter greater difficulties in performing activities of daily living. A multidisciplinary approach is needed when considering treatment for these types of patients.
Promoted Dissipation and Detoxification of Atrazine by Graphene Oxide Coexisting in Water
Authors: Wang Qinghai , Peng Lei , Zhou Zixin , Li Cui , Chen Chuansheng , Wang Yu , Que Xiaoe 
Published: February 2023

Abstract
Herbicide atrazine (ATZ) has a detrimental effect on health of aquatic ecosystems, and has become a global concern in recent years. but understanding of its persistence and potential toxicity under combined pollution, especially in the coexistence of other emerging pollutants, remains limited. In this work, the dissipation and transformation of ATZ in combination with graphene oxide (GO) in water were investigated. Results showed that dissipation rates of ATZ dramatically increased by 15%-95% with half-lives shortened by 15%-40% depending on initial concentrations of ATZ, the products were mainly toxic chloro-dealkylated intermediates (deethylatrazine (DEA) and deisopropylatrazine (DIA)), but their contents were significantly lower under coexistence of GO compared to ATZ alone. In the presence of GO, the nontoxic dechlorinated metabolite hydroxyatrazine (HYA) was detected earlier than 2-9 days, and ATZ transformation into HYA was increased by 6%-18% during 21-day incubation periods. This study indicated that the coexistence of GO enhanced the dissipation and detoxification of ATZ. From a remediation standpoint, GO-induced hydrolytic dechlorination of ATZ can reduce its ecological toxicity. But the environmental risks of ATZ for aquatic ecosystem under the coexistence of GO should still be given necessary prominence due to potential hazard of ATZ adsorbed on GO and predominant degradation products (DEA and DIA).
Cryoablation for nonmetastatic castration resistant prostate cancer: feasibility, safety, quality of life and oncological outcomes
Authors: Wang Yanqing , Zhu Yinjie , Xia Binbin , Du Xinxing , Wu Fan , Xu Fan , Pan Jiahua , Dong Baijun , Xue Wei 
Published: February 2023

Abstract
Background: Cryoablation is an effective local therapy for prostate cancer for its local tumor killing and activation of systemic immune response. We sought to investigate the feasibility, safety, quality of life (QOL) and oncological outcomes of cryoablation for nonmetastatic castration resistant prostate cancer (CRPC).
Methods: The clinical data of 16 patients at our center treated with cryoablation for nonmetastatic CRPC between Jun 2014 and Aug 2018 were analyzed retrospectively. The progression-free survival (PFS) distribution was estimated by Kaplan-Meier analyses and compared by a log-rank test.
Results: Median follow-up duration was 32.0months (interquartile range, IQR, 19.6-57.4). There was a Clavien II complication in 1 patient after cryoablation. 5 patients had a clinically significant increase and 2 patients had a clinically significant decrease in Expanded Prostate Cancer Index Composite urinary function QOL score at 3 months postoperation. 14 patients had a decline in prostate-specific antigen(PSA) within 3 months postoperation. PSA progression was occurred in all the patients, and the median PSA PFS time was 3.1months (IQR, 1.9-22.9). The patients with obvious lesion in the prostate of preoperative MRI or PSA < 5.33 ng/ml prior to cryoablation had a better survival (P < 0.05). The immune activation was occurred in 13 patients at 1 day postoperation.
Conclusions: Cryoablation has advantages of safety, elevated urinary function QOL, promising oncological outcome and is an appropriate option for patients with nonmetastatic CRPC, especially for those with obvious lesion in the prostate of preoperative MRI or PSA < 5.33 ng/ml prior to cryoablation.
Implementation Difficulties and Solutions of a Smart-Cloth assisted Home Nursing Care Program for disabled older persons
Authors: Lin Chung-Chih , Yang Ching-Tzu , Su Pei-Ling , Hsu Jung-Ling , Shyu Yea-Ing , Hsu Wen-Chuin 
Published: February 2023

Abstract
Background:Wearable devices have the advantage of always being with individuals, enabling easy detection of their movements. In this study, we developed and implemented a smart-care system using smart clothing for persons with dementia and with hip fracture.
Objective:This paper reports conducted a preliminary study to understand family caregivers’ and care receivers’ experiences of receiving a smart technology-assisted (STA) home-nursing care program.
Methods: The STA model of a home-nursing care program for older persons with dementia or hip fracture included a remote-monitoring system with a smart-vest to facilitate family caregivers’ detection of the care receivers’ movements. These movements included getting up at night, staying in the bathroom time, not moving time during the day, leaving the house, and daily activity level. Participants included 12 families with five patients with hip fracture and seven with dementia. A description of the process of setting up the individual STA in-home systems, measures that were monitored and the difficulties encountered.
Results: Difficulties encountered were due to multiple problems. They were comprised of three categories: incompatibility of the home environment, interruptions in data transmissions and inaccuracies in data transmissions.
Conclusions: Three main difficulties impeded implementation of the STA home care for persons with dementia or hip fracture. Each of these difficulties had their own unique problems and strategies to resolve them. Our findings can provide a reference for futureimplementation of similar smart-home systems.