bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diverse research teams: A framework for research review
Authors: Akbar Skye , Greenacre Luke , Defina Rebecca , Garay Lorraine 
Published: December 2022

Indigenous groups voices have often been missing from the marketing research collegiate. The Aboriginal and Torres Strait Islander Peoples of the land now known as Australia, for example, are among the most researched peoples in the world (Martin & Mirraboopa, 2003), yet are underrepresented among research practitioners. The present underrepresentation among practitioners is only slowly, and occasionally haphazardly, being addressed by the growing number of more junior Indigenous researchers entering the field. Until greater representation among senior researchers is achieved, research teams are likely to include a mixture of Indigenous and non-Indigenous researchers. Such teams must therefore address a unique combination of power imbalance and minority inclusion in how they work. This need for inclusion can become more challenging for research teams when the research topic addresses issues impacting Indigenous peoples. And while numerous ethical and research guidelines exist for how researchers work with participants who are members of a minority group and are likely to have less power, there are few frameworks addressing how such challenges should be managed for the researchers within a research team. In this paper, we use an action research method to critically reflect on how to manage research teams that include more junior Indigenous researchers whose voices are vital to the research project. Reflexive and proactive processes were developed to ensure a culture of reflection both regarding interactions within the research team and in the project. To structure and share these reflections, the team developed and enunciated a fit-for-purpose framework. This framework was informed by the work of Narungga Professor Rigney (1999) that lists foundational Indigenist research methods. The framework also draws on the layers of reflexivity proposed by Nicholls (2009) and insider/outsider group theory previously advocated for (Ameka, 2018).
Three-dimensional rotational angiography improves mechanical thrombectomy recanalization rate for acute ischaemic stroke due to middle cerebral artery M2 segment occlusions
Authors: Rosi Andrea , Bernava Gianmarco , Hofmeister Jeremy , Nicolò Madruzzato , Boto José , Yilmaz Hasan , Reymond Philippe , Brina Olivier , Muster Michel , Carrera Emmanuel , Lövblad Karl-Olof , Machi Paolo 
Published: December 2022

Background Occlusions of the middle cerebral artery (MCA) M2 segments can be difficult to address with mechanical thrombectomy (MTB) using standard projections and this can affect the final recanalization. Three-dimensional rotational angiography (3D-RA) allows to obtain a 3D model of cerebral vessels in a few seconds and to determine the best two-dimensional (2D) projections to be selected to evaluate and treat cerebrovascular diseases, such as aneurysms or vascular malformations. We aimed to determine if 3D-RA could be applied also in MTB. Methods A retrospective review of two patient cohorts treated during two time periods of 12 months before and after the introduction of 3D-RA use at our institution for MTB in M2 occlusions. Analyses were conducted to compare the two groups for procedural characteristics, such as timing, recanalization rate and complications and clinical outcome. Results One hundred acute ischaemic stroke (AIS) patients (3D-RA group = 57; controls = 43) underwent MTB for an M2 occlusion during the two study periods. Recanalization rates were significantly higher in cases treated with 3D-RA. The mean 3D technique thrombectomy time was compared to that of non-3D cases (47 vs. 49 min, respectively). Conclusions Our findings showed that 3D-RA is a useful tool to select specific working projections to AIS patients presenting an M2 occlusion by improving final recanalization compared to standard projections, without increasing the overall procedural time.
Long-term efficacy and safety of neridronate treatment in patients with complex regional pain syndrome type 1: a pre-specified, open-label, extension study
Authors: Varenna Massimo , Gatti Davide , Zucchi Francesca , Crotti Chiara , Braga Vania , Iolascon Giovanni , Frediani Bruno , Nannipieri Fabrizio , Rossini Maurizio 
Published: December 2022

Background: No data on the permanent and curative effect of bisphosphonate treatment in patients with complex regional pain syndrome type-1 (CRPS-1) are currently available. The aim of this pre-specified, open-label, observational study was to evaluate the long-term efficacy and safety of neridronate treatment. Design: A pre-specified, open-label, extension study. Methods: Patients treated with intramuscular (IM) placebo in the double-blind phase of the study were assigned to 100 mg intravenous (IV) neridronate treatment administered 4 times over 10 days. These patients, together with those previously treated with 400 mg IM neridronate, were followed for 1 year. Efficacy was assessed using a visual analogue scale (VAS) pain score. Changes in clinical signs and symptoms, quality of life (QoL) using the Short Form Health Survey (SF-36), and the McGill Pain Questionnaire were also assessed. Results: Benefits on pain, clinical and functional measures were maintained and further improved over 12 months in most patients treated with neridronate administered either IM or IV. In IM-treated patients, the percentage of those defined as responders (VAS score reduction ≥ 50%) progressively increased up to day 360 to 32 of 35 patients (91.4%). Among the 27 patients referred to as responders at the end of the double-blind phase, 26 reported the same result at day 360 (96.3%). In IV-treated patients, a responder rate of 88% (22 out 25) was found at day 360 (p = 0.66 between groups). Consistent improvements were also observed for all clinical signs and functional questionnaire. No drug-related adverse events were reported during the study. Conclusion: In patients with acute CRPS-1, the benefit in pain, clinical, and functional measures observed a few weeks after neridronate treatment administered either IM or IV is maintained and further improved over 12 months. Parenteral neridronate induces permanent disease remission preventing chronic pain and motor dysfunction. Trial registration: EU Clinical Trials Register (EudraCT Number): 2014-001156-28
In-Hospital Cost Comparison for Open Versus Endoscopic Endonasal Approach for Meningioma Resection
Authors: Parasher Arjun K. , Lerner David K. , Miranda Stephen P. , Douglas Jennifer E. , Glicksman Jordan T. , Alexander Tyler , Lin Theodore , Ebesutani Darren , Kohanski Michael , Lee John Y.K. , Storm Phillip B. , O’Malley Bert W. , Yoshor Daniel , Palmer James N. , Grady M. Sean , Adappa Nithin D. 
Published: December 2022

Objective To determine the in-hospital cost implications of an endoscopic expanded endonasal approach (EEEA) for meningioma resection relative to the open transcranial approach. Methods All anterior skull base meningioma surgeries performed over a period from January 1st, 2015 to October 31th, 2017 were evaluated. The electronic medical record was reviewed for patient factors, tumor characteristics, and cost variables associated with each hospital stay and univariate analysis was performed using R software. All cost data were converted into August 2021-equivalent dollar amounts using the United States Bureau of Labor Statistics consumer price index. Results Thirty-five patients met study criteria, including 27 patients undergoing an open transcranial approach and 8 undergoing an EEEA. Average length of stay for patients undergoing an open approach was 9.3 days compared to 5.6 within the EEEA group ( P = .126). The average total in-hospital cost of patient undergoing an EEEA was $35417.1 compared to $46406.9 among patients undergoing an open transcranial approach ( P = .168). On univariate analysis, the cost of an open transcranial approach relative to the EEEA was $10989.8 ( P = .411). Conclusions The open transcranial approach remained the dominant surgical approach to anterior skull base meningiomas over our study time period. However, despite limited patient numbers the EEEA was associated with decreased total in-hospital costs.
Clinical performance of lithium disilicate and zirconia CAD/CAM crowns using digital impressions: A systematic review
Authors: Benli Merve , Turkyilmaz Ilser , Martinez Jacqueline L. , Schwartz Shelby 
Published: December 2022

Purpose: The purpose of this systematic review was to compare the clinical performance of lithium disilicate (LDS) and zirconia (Z) single crowns manufactured by computer-aided design/computer-aided manufacturing (CAD/CAM) systems using intraoral optical scanners (IOS). Materials and methods: An electronic search for articles published between January 2012 and January 2022 in the English language was performed with the Medline/Pubmed database under the guidelines of Preferred Reporting Items for Systemic Reviews and Meta-analysis (PRISMA). The specific search terms used were “zirconia”, “lithium disilicate”, “CAD/CAM”, “intraoral optical scanner”, and “survival”. Results: The initial electronic search resulted in 278 articles. Most of the resulting articles were excluded, six clinical studies addressing the clinical outcomes of Z and LDS crowns fitted the inclusion criteria and were selected for review. Of these six studies, three were randomised controlled trials, two were retrospective studies, and one was a prospective study. To quantify the clinical performance of the crowns several parameters were recorded, including fractures, endodontic complications, periodontal complications, technical complications, aesthetic complications, and biological complications. It was noted that the most common technical complication of Z and LDS crowns was chipping at a rate of 1.4% and 5% respectively. Regarding Z crowns, aesthetic concerns were the most frequently observed complication. Conclusion: The outcomes of this systematic review indicate that Z and LDS crowns display a similar incidence of periodontal and endodontic complications when compared to metal-ceramic crowns, suggesting that these all-ceramic materials are viable alternatives. The incidence of chipping was higher in LDS crowns compared to other materials, while Z crowns were inferior in terms of aesthetics.
CAD/CAM technology for fabrication of reduction guide for RPD parallel guiding planes preparation: A dental technique
Authors: Carvalho Porto de Freitas Rodrigo Falcão , Carneiro Pereira Ana Larisse , da Fonte Porto Carreiro Adriana 
Published: December 2022

Introduction: The preparation of parallel axial wall guide planes in abutment teeth is essential for providing a correct path of insertion and removal axis for removable partial dentures (RPDs). With the introduction of digital resources, new alternatives to the conventional method can be used to manufacture guide preparation for guide planes. Aims: To describe the use of computer-aided design/computer-aided manufacturing (CAD/CAM) technology for the manufacture of guide planes to guide the reduction of the axial walls of abutment teeth according to the insertion and removal axis of the RPD. Methods: This technique used the “bite splint” module of the Dental Wings software for the virtual planning of guide planes, to promote the construction of axial walls parallel to the abutment teeth. This was performed from the virtual design on a standard tessellation language (STL) file obtained by intraoral scanning, which determined the best trajectory for insertion and removal of the metallic structure. Conclusion: Digital technology allows the design and production of guide planes for the preparation of abutment teeth, simplifying the conventionally used technique, with precision and speed.
Argentotetrahedrite-(Cd), Ag6(Cu4Cd2)Sb4S13, a new member of the tetrahedrite group from Rudno nad Hronom, Slovakia.
Authors: Mikuš Tomáš , Vlasáč Jozef , Majzlan Juraj , Sejkora Jiří , Steciuk Gwladys , Plášil Jakub , Rößler Christiane , Matthes Christian 
Published: December 2022

AbstractArgentotetrahedrite-(Cd), Ag6(Cu4Cd2)Sb4S13, has been approved as a new mineral species by the Commission on New Minerals, Nomenclature and Classification of the International Mineralogical Association using samples from Rudno nad Hronom, Slovak Republic. It occurs as anhedral grains up to 30 μm in size, steel-grey to black in colour, with a metallic lustre, in association with greenockite and other tetrahedrite-group minerals [argentotetrahedrite-(Zn) and tetrahedrite-(Zn)], earlier base-metal minerals, Ag sulfides and sulfosalts (acanthite, pyrargyrite and polybasite) and later galena. Argentotetrahedrite-(Cd) is isotropic, grey in colour, with a creamy tint and rapidly (tens of minutes) tarnishes to orange–brown. Reflectance data for Commission on Ore Mineralogy (COM) wavelengths in air are [λ (nm), R (%)]: 470, 30.4; 546, 30.3; 589, 30.3; and 650, 28.7. The chemical formula of the samples studied, recalculated on the basis of ΣMe = 16 atoms per formula unit, is: (Ag3.28Cu2.72)Ʃ6.00[Cu4(Cd1.68Fe0.27Zn0.16)]Ʃ6.11(Sb3.71As0.15)Ʃ3.86S12.79. Argentotetrahedrite-(Cd) is cubic, I$\bar{4}$3m, with a = 10.65(2) Å, V = 1208(4) Å3 and Z = 2. Argentotetrahedrite-(Cd) is isotypic with other members of the tetrahedrite group. The structural relationship between argentotetrahedrite-(Cd) and other members of the freibergite series are discussed and previous findings of this species are briefly reviewed.
Single-cell transcriptomic analysis reveals differential cell subpopulations and distinct phenotype transition in normal and dissected ascending aorta
Authors: He Yu-bin , Jin Hai-zhen , Zhao Jin-long , Wang Chong , Ma Wen-rui , Xing Jie , Zhang Xiao-bin , Zhang Yang-yang , Dai Huang-dong , Zhao Nai-shi , Zhang Jian-feng , Zhang Guan-xin , Zhang Jing 
Published: December 2022

Abstract
Background
Acute thoracic aortic dissection (ATAD) is a fatal condition characterized by tear of intima, formation of false lumen and rupture of aorta. However, the subpopulations of normal and dissected aorta remain less studied.

Methods
Single-cell RNA sequencing was performed including 5 patients with ATAD and 4 healthy controls. Immunohistochemistry and immunofluorescence were used to verify the findings.

Results
We got 8 cell types from human ascending aorta and identified 50 subpopulations including vascular smooth muscle cells (VSMCs), endothelial cells, fibroblasts, neutrophils, monocytes and macrophages. Six transmembrane epithelial antigen of prostate 4 metalloreductase (STEAP4) was identified as a new marker of synthetic VSMCs. CytoTRACE identified subpopulations with higher differentiation potential in specified cell types including synthetic VSMCs, enolase 1+ fibroblasts and myeloid-derived neutrophils. Synthetic VSMCs-derived C-X-C motif chemokine ligand 12 (CXCL12) might interact with neutrophils and fibroblasts via C-X-C motif chemokine receptor 4 (CXCR4) and atypical chemokine receptor 3 (ACKR3), respectively, which might recruit neutrophils and induce transdifferentitation of fibroblasts into synthetic VSMCs.

Conclusion
We characterized signatures of different cell types in normal and dissected human ascending aorta and identified a new marker for isolation of synthetic VSMCs. Moreover, we proposed a potential mechanism that synthetic VSMCs might interact with neutrophils and fibroblasts via CXCL12-CXCR4/ACKR3 axis whereby deteriorating the progression of ATAD, which might provide new insights to better understand the development and progression of ATAD.
VANet: a medical image fusion model based on attention mechanism to assist disease diagnosis
Authors: Guo Kai , Li Xiongfei , Fan Tiehu , Hu Xiaohan 
Published: December 2022

Abstract

Background

Today’s biomedical imaging technology has been able to present the morphological structure or functional metabolic information of organisms at different scale levels, such as organ, tissue, cell, molecule and gene. However, different imaging modes have different application scope, advantages and disadvantages. In order to improve the role of medical image in disease diagnosis, the fusion of biomedical image information at different imaging modes and scales has become an important research direction in medical image. Traditional medical image fusion methods are all designed to measure the activity level and fusion rules. They are lack of mining the context features of different modes of image, which leads to the obstruction of improving the quality of fused images.

Method

In this paper, an attention-multiscale network medical image fusion model based on contextual features is proposed. The model selects five backbone modules in the VGG-16 network to build encoders to obtain the contextual features of medical images. It builds the attention mechanism branch to complete the fusion of global contextual features and designs the residual multiscale detail processing branch to complete the fusion of local contextual features. Finally, it completes the cascade reconstruction of features by the decoder to obtain the fused image.

Results

Ten sets of images related to five diseases are selected from the AANLIB database to validate the VANet model. Structural images are derived from MR images with high resolution and functional images are derived from SPECT and PET images that are good at describing organ blood flow levels and tissue metabolism. Fusion experiments are performed on twelve fusion algorithms including the VANet model. The model selects eight metrics from different aspects to build a fusion quality evaluation system to complete the performance evaluation of the fused images. Friedman’s test and the post-hoc Nemenyi test are introduced to conduct professional statistical tests to demonstrate the superiority of VANet model.

Conclusions

The VANet model completely captures and fuses the texture details and color information of the source images. From the fusion results, the metabolism and structural information of the model are well expressed and there is no interference of color information on the structure and texture; in terms of the objective evaluation system, the metric value of the VANet model is generally higher than that of other methods.; in terms of efficiency, the time consumption of the model is acceptable; in terms of scalability, the model is not affected by the input order of source images and can be extended to tri-modal fusion.
An improved algorithm for flux variability analysis
Authors: Kenefake Dustin , Armingol Erick , Lewis Nathan E. , Pistikopoulos Efstratios N. 
Published: December 2022

AbstractFlux balance analysis (FBA) is an optimization based approach to find the optimal steady state of a metabolic network, commonly of microorganisms such as yeast strains and Escherichia coli. However, the resulting solution from an FBA is typically not unique, as the optimization problem is, more often than not, degenerate. Flux variability analysis (FVA) is a method to determine the range of possible reaction fluxes that still satisfy, within some optimality factor, the original FBA problem. The resulting range of reaction fluxes can be utilized to determine metabolic reactions of high importance, amongst other analyses. In the literature, this has been done by solving $$2n+1$$

2
n
+
1

linear programs (LPs), with n being the number of reactions in the metabolic network. However, FVA can be solved with less than $$2n+1$$

2
n
+
1

LPs by utilizing the basic feasible solution property of bounded LPs to reduce the number of LPs that are needed to be solved. In this work, a new algorithm is proposed to solve FVA that requires less than $$2n+1$$

2
n
+
1

LPs. The proposed algorithm is benchmarked on a problem set of 112 metabolic network models ranging from single cell organisms (iMM904, ect) to a human metabolic system (Recon3D). Showing a reduction in the number of LPs required to solve the FVA problem and thus the time to solve an FVA problem.
Genome-wide association study identifies novel loci associated with skin autofluorescence in individuals without diabetes
Authors: Vollenbrock Charlotte E. , Roshandel Delnaz , van der Klauw Melanie M. , Wolffenbuttel Bruce H. R. , Paterson Andrew D. 
Published: December 2022

Abstract
Background
Skin autofluorescence (SAF) is a non-invasive measure reflecting accumulation of advanced glycation endproducts (AGEs) in the skin. Higher SAF levels are associated with an increased risk of developing type 2 diabetes and cardiovascular disease. An earlier genome-wide association study (GWAS) revealed a strong association between NAT2 variants and SAF. The aim of this study was to calculate SAF heritability and to identify additional genetic variants associated with SAF through genome-wide association studies (GWAS).

Results
In 27,534 participants without diabetes the heritability estimate of lnSAF was 33% ± 2.0% (SE) in a model adjusted for covariates. In meta-GWAS for lnSAF five SNPs, on chromosomes 8, 11, 15 and 16 were associated with lnSAF (P < 5 × 10–8): 1. rs2846707 (Chr11:102,576,358,C > T), which results in a Met30Val missense variant in MMP27 exon 1 (NM_022122.3); 2. rs2470893 (Chr15:75,019,449,C > T), in intergenic region between CYP1A1 and CYP1A2; with attenuation of the SNP-effect when coffee consumption was included as a covariate; 3. rs12931267 (Chr16:89,818,732,C > G) in intron 30 of FANCA and near MC1R; and following conditional analysis 4. rs3764257 (Chr16:89,800,887,C > G) an intronic variant in ZNF276, 17.8 kb upstream from rs12931267; finally, 30 kb downstream from NAT2 5. rs576201050 (Chr8:18,288,053,G > A).

Conclusions
This large meta-GWAS revealed five SNPs at four loci associated with SAF in the non-diabetes population. Further unravelling of the genetic architecture of SAF will help in improving its utility as a tool for screening and early detection of diseases and disease complications.