bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Network Analysis Bridging the Gap Between the Big Five Personality Traits and Burnout Among Medical Staff
Authors: Wang Yifei , Wu Lin , Wang Mei , Feng Tingwei , Wang Qingyi , Chao Wu , Ren Lei , Liu Xufeng 
Published: September 2023

Abstract
Background
Burnout is a common issue among medical professionals, and one of the well-studied predisposing factors is the Big Five personality traits. However, no studies have explored the relationships between these traits and burnout from a trait-to-component perspective. To understand the specific connections between each Big Five trait and burnout components, as well as the bridging effects of each trait on burnout, we employed network analysis.
Methods
A cluster sampling method was used to select a total of 420 Chinese medical personnel. The 15-item Chinese Big Five Personality Inventory-15 (CBF-PI-15) assessed the Big Five personality traits, while the 15-item Maslach Burnout Inventory-General Survey (MBI-GS) assessed the effects of these traits on burnout. The calculated model used a regularized graphical Gaussian model, and each node in the final network represented the expected influence from the bridge.
Results
The study revealed distinct and clear relationships between the Big Five personality traits and burnout aspects. For instance, Neuroticism was related to doubt and worth, while Extraversion was related to doubt. Among the Big Five traits, Neuroticism displayed the highest positive bridge centrality, while Conscientiousness displayed the highest negative bridge centrality.
Conclusions
The network model provides a means to investigate the connections between the Big Five personality traits and burnout elements among medical professionals. This study offers new avenues for thought and potential targets for burnout treatment in medical personnel, which can be further explored and tested in clinical settings.
Exploring the potential of Natural Chitosan Extracted from Cockroaches in Zinc-rich Epoxy Paints on Carbon Steel to improve the Corrosion resistance of Coating
Authors: Sheikholeslami Arman , Ababaf Ahmad Nejad , Jafari Esmaeil 
Published: September 2023

Abstract
Due to global environmental concerns, many efforts have been made to prepare environmentally friendly and biodegradable materials .This study investigated the effectiveness of natural chitosan extracted from cockroaches as corrosion inhibitors for zinc epoxy paints on carbon steel in harsh environment. chitosan was extracted from shells of cockroaches using a simple and cost-effective method, and two types of industrial chitosan were purchased from a commercial source for comparison. Different concentrations of each chitosan were added to zinc-rich epoxy paints, which were applied on carbon steel samples and exposed to desulfovibrio in a culture medium. The corrosion behavior was evaluated using potentiodynamic polarization test, and the SEM and XRD analysis provided further insights into the morphology and chemical compositions of the coatings. The results demonstrate the potential of natural chitosan extracted from cockroaches as an effective corrosion inhibitor for zinc epoxy paints on carbon steel in corrosive environments, specifically against desulfovibrio, and highlight natural chitosan's superiority over industrial chitosan for this application.
Optimization of Surface Texture in Double Rectangular Cavity Hydrostatic Thrust Bearing Through GA genetic algorithm
Authors: Yu Xiaodong , Wang Yihan , Liu Haixin , Zhao Feihu , Li Ruichao , Sun Kaixuan , Guan Libo , Dai Ruichun , Jia Wentao , Wang Junfeng , Jiang Hui , Jiao Jianhua 
Published: September 2023

Abstract
Optimization of surface texture in liquid hydrostatic thrust bearing is particularly important in order to improve quality of processed products. There are excellent nonlinear ability and quite flexible network structure in BP neural networks, which can be used to achieve optimization of surface texture in all aspects of thrust bearing. The model of surface texture size parameters and the oil cavity pressure are established by BP neural network, and the experiment is designed based on orthogonal experimental samples. The optimal parameters of the texture size were optimized using the GA genetic algorithm, yielding a distance L = 1.2323 between the texture and the oil cavity, a width B = 0.99547, a depth H = 1.4714, and a corresponding mean pressure of the oil cavity P = 0.11882MPa. In particular, the sensitivity simulation method is able to find the optimal number of "type 1" surface textures on the oil sealing edge.
Accumulation of microbial residuals and lignin phenols in forest soils along the latitude
Authors: Lin Qiaoling , Tian Qiuxiang , Liao Chang , Yuan Xudong , Lu Mengzhen , Liu Feng 
Published: September 2023

Abstract
Aims
The carbon inputs from plant and microbial sources mainly govern the storage of soil organic carbon (SOC). However, how their relative contributions to SOC may vary along broad-scale environmental gradients is still poorly understood; the vertical distribution of these two carbon sources in soils is also elusive.
Methods
We selected amino sugar (microbial-derived carbon) and lignin phenol (plant-derived carbon) as biomarkers. The accumulation of amino sugar and lignin phenol in topsoil (0-10cm) and subsoil (30-50cm) of major forest types along latitude gradients in China was quantified.
Results
Our result showed that amino sugar concentrations decreased along latitude in topsoil. This was mainly influenced by annual mean temperature (MAT) and soil nitrogen (N). Lignin phenol concentrations decreased along latitude in topsoil, mainly influenced by soil C/N ratio. The soil amino sugar concentrations in topsoil were lower than those in subsoil, and the opposite was true for lignin phenols. In topsoil, the microbial-derived carbon was mainly composed of fungi-derived carbon, while in subsoil, bacteria-derived carbon dominated.
Conclusions
The microbial residues were mainly influenced by climate and soil properties. The lignin phenols were mainly controlled by soil properties. The controlling factors for microbial residues and lignin phenols in topsoil and subsoil are different. Our works have established a connection among climate, vegetation, and soil, revealing significant mechanisms for the vertical distribution of carbon sequestration along a latitude gradient.
Photospheric Velocities Measured at Mt. Wilson Show Rotational and Poleward Velocity Deviations Compose the Torsional Oscillations
Authors: Ulrich Roger K. , Tran Tham , Boyden John 
Published: September 2023

Abstract
The methods for reducing the observations from the 150-foot Tower Telescope on Mt. Wilson are reviewed and a new method for determining the Poleward and Rotational velocity deviations is described and applied. The flows we study are smaller than global and change with the solar cycle so we describe them as poleward and rotational deviations rather than meridional circulation when we are discussing solar surface flows. Due to a calibration problem with the data prior to 1983, only observations between 1983 and 2013 are presented at this time. After subtraction of latitude dependent averages over the 30-year period of observation the residual deviations in the poleward and rotational velocity deviations are well synchronized and correspond to what is widely recognized as the Torsional Oscillations. Both flow components need to be included in any model that replicates the Torsional Oscillations.
Manipulation of co-pelletization for Chlorela vulgaris harvest by treatment of Aspergillus niger spore
Authors: Zheng Xiao , Cong Wenjie , Gultom Sarman Oktovianus , Wang Mingxuan , Zhou Hualan , Zhang Jianguo 
Published: September 2023

Abstract
The co-pelletization of microalgae with filamentous fungi was a promising approach for microalgae harvest. However, the real conditions of microalgae growth limited the arbitrary optimization of co-pellets formation with filamentous fungi. Therefore, it is urgent to develop an approach to manipulate the co-pelletization through treatment of A. niger spores. In this study, Aspergillus niger and Chlorella vulgaris were used as the model species of filamentous fungi and microalgae to investigate co-pellets formation using A. niger spores after by different pH solutions treatment, swelling, snailase treatment. The importance of spore treatments on C. vulgaris harvest in sequence was claimed based on response surface methodology analysis. The pH solutions treatment, swelling, snailase treatment of A. niger spore contributed 21.0%, 10.5%, 40.7% of harvest ratio of C. vulgaris respectively, which guided the application of spore treatment into co-pelletization. Treatment of spore was showed as an efficient approach to manipulate co-pelletization for microalgae harvest in diverse microalgae condition. This results promoted the application of co-pelletization technology in microalgae harvest of various conditions.
Learning curve analysis of robotic-assisted total knee arthroplasty with the HURWA surgical system
Authors: Zhang Haoran , Bai Xizhuang , Wang Huisheng , Yu Zhongshen , Yan Zenglong , Zhang Pan , Song Meng , Qun Feng , Wang Tianyi , Zhu Zhiyong , Li Xi 
Published: September 2023

Abstract
Purpose The aim of this study was to analyze the learning curve of total operative time, bone-cutting accuracy, and limb alignment in robot-assisted total knee arthroplasty (TKA) using the innovative image-based knee surgery robot known as HURWA. Additionally, a comparison was conducted with conventional TKA to ascertain the benefits of robotic-assisted TKA.Methods In this retrospective study, we analyzed a series of patients (n = 90) who underwent robotic-assisted total knee arthroplasty using the HURWA robot between December 2021 and October 2022. The procedures were performed by one of three orthopedic surgeons with varying levels of experience. As a control group, we selected the last 30 conventional TKA cases performed by each of these three surgeons. To determine the learning curve, we recorded the operative time, bone-cutting error, and pre- and postsurgery radiographs.Results The study found no significant differences in total operative time, bone-cutting accuracy, or limb alignment between the three surgeons. Of the three surgeons, surgeon 1, who had the most experience in joint arthroplasty, reached the learning curve in case 8, with the shortest bone-cutting time and robot time. Surgeon 2 reached the learning curve in case 16, while surgeon 3 reached the learning curve in case 9. There was no observable learning curve effect for bone-cutting accuracy and limb alignment. However, the percentage of cases where limb alignment differed from preoperative planning by 3° or less was higher in robotic-assisted TKA (77.97%) compared to conventional TKA (47.19%).Conclusion The study determined that the learning curve for robotic-assisted TKA using the HURWA knee surgery robot ranged from 8 to 20 cases. No observable learning curve effect was detected for bone-cutting accuracy or limb alignment. Experienced surgeons using the HURWA robot for bone- cutting took less time and reached the learning curve earlier. The HURWA robot achieved better limb alignment without depending on the experience of conventional TKA.The Translational Potential of this Article: The study of the learning curve of the surgical robot will give an indication of the ease of learning of the surgical robot and thus provide strong evidence for the extension and diffusion of the surgical robot to primary hospitals.
ARID1B Deficiency Leads to Impaired DNA Damage Response and Activated cGAS- STING Pathway in Non-Small Cell Lung Cancer
Authors: Zhu Guangsheng , Liu Jinghao , Li Yongwen , Huang Hua , Chen Chen , Wu Di , Cao Peijun , Su Lianchun , Wang Yanan , Zhang Hongbing , Liu Hongyu , Chen Jun 
Published: September 2023

Abstract
Purpose
Lung cancer is a major cause of morbidity and mortality globally, necessitating the identification of predictive markers for effective immunotherapy. Mutations in SWI/SNF chromatin remodeling complex genes were reported sensitized human tumors to immune checkpoint inhibitors (ICIs), but the underlying mechanisms are unclear. This study aim to investigates the association between SWI/SNF gene ARID1B mutation and ICI response in non-small cell lung cancer (NSCLC) patients, to explore the functional consequences of ARID1B mutation on DNA damage response, immune microenvironment, and cGAS-STING pathway activation.
Methods
TCGA LUAD, LUSC, and AACR GENIE data are analyzed to assess ARID1B mutation status in NSCLC patients. Prognostic analysis evaluates the effect of ARID1B mutation on patient outcomes. In vitro experiments carried to investigate the consequences of ARID1B knockdown on DNA damage response and repair. The immune microenvironment is assessed based on ARID1B expression, and the relationship between ARID1B and the cGAS-STING pathway is explored.
Results
ARID1B mutation frequency is 5.7% in TCGA databases and 4.4% in the AACR GENIE project. NSCLC patients with ARID1B mutation showed improved overall and progression-free survival following ICIs treatment. ARID1B knockdown in lung cancer cell lines enhances DNA damage, impairs DNA repair, alters chromatin accessibility, and activates the cGAS-STING pathway. ARID1B deficiency is associated with immune suppression, indicated by reduced immune scores, decreased immune cell infiltration, and negative correlations with immune-related cell types and functions.
Conclusion
ARID1B mutation may predict improved response to ICIs in NSCLC patients. ARID1B mutation leads to impaired DNA damage response and repair, altered chromatin accessibility, and cGAS-STING pathway activation. These findings provide insights into ARID1B's biology and therapeutic implications in lung cancer, highlighting its potential as a target for precision medicine and immunotherapy. Further validation and clinical studies are warranted.
Effect of alternating nicotinamide phosphoribosyltransferase expression levels on mitophagy and pathological symptoms in Alzheimer’s disease mouse models
Authors: Zhao Na , Xu Bo , Xia Jie , Wang Jing , Zhang Xianliang , Yan Qingwei 
Published: September 2023

Abstract
Alzheimer's disease (AD) is a neurodegenerative disease characterized by progressive cognitive dysfunction. Extensive studies have demonstrated that mitochondrial dysfunction and mitophagy impairment contribute substantially to the pathogenesis of AD. Recent studies have shown that nicotinamide adenine dinucleotide (NAD+) augmentation restores mitophagy and removes the defective mitochondria. Nicotinamide phosphoribosyltransferase (NAMPT) is a rate-limiting enzyme in the salvage pathway of NAD+ synthesis. Therefore, this study aims to provide evidence for the role of the NAMPT-NAD +-silent information-regulated transcription factors-1 (SIRT1) axis in mediating mitophagy in 6-month-old APP/PS1 transgenic mice. The results showed that NAMPT expression in the hippocampus of APP/PS1 mice significantly decreased. However, NAMPT was upregulated using P7C3 (NAMPT activator), which significantly increased NAD+-SIRT1-FOXO1/3a signaling pathway, enhanced mitophagy activity, and improved mitochondrial structure and function as well as learning and memory ability. Whereas NAMPT was downregulated under the FK866 treatment (NAMPT inhibitor), therefore reversing the pathways, and even exacerbating Aβ plaque deposition level in the hippocampus of APP/PS1 mice. Our findings suggest that preventing the downregulation of NAMPT can abolish AD-related mitophagy impairment and that NAMPT represents a potential therapeutic intervention in AD pathogenesis.
Prognostic implications of a four-gene signature in non-muscle invasive bladder cancer
Authors: Duan Huangqi , Yu Shenggen , Xia Weimin , Wang Chen , Zhang Shun , Shen Yu , Cao Qifeng , Xu Ding , Liu Hailong , Shen Haibo 
Published: September 2023

Abstract
The high recurrence rate of non-muscle invasive bladder cancer (NMIBC) is a non-negligible problem in a clinical setting. Therefore, it is important to explore the affecting factors and to identify promising biological indicators that could predict the recurrence hazard. The present study employed a CIBERSORT computational method to characterize the immune cell infiltration (ICI) landscape using 549 NMIBC cases from the training cohort. Three ICI phenotypes were characterized and differentially expressed genes (DEGs) were identified and evaluated using Cox regression analysis and protein-protein interaction network construction. A four-gene signature for prognostic prediction in NMIBC patients was ultimately established, which was further evaluated by Kaplan-Meier analysis, revealing a significant recurrence-free survival (RFS) difference. The signature was constructed to stratify NMIBC patients into high- and low-risk groups. For patients in the high-risk group, significantly reduced RFS was observed when compared to patients in the low-risk group. Tissue validation results also showed that CDC20, CPL3A1, PLK1, and FOXM1 were differentially expressed between tumor and normal tissues from NMIBC patients. Results of the receiver operating characteristic curve (ROC) analysis demonstrated that the signature had a significant predictive power for NMIBC recurrence. Furthermore, Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analyses showed that the signature manifested close interactions with cell-cycle pathways and tumor environment. In conclusion, this novel cell cycle-related four-gene signature can be used for prognostic prediction in NMIBC.
Enhancing Mesenchymal Stem Cell Culture on Microcarriers in Spinner Flask via Impeller Design Optimization for Aggregated Suspension
Authors: Zhang Botao , Lu Qiaohui , Dai Gance , Zhou Yi , Ye Qian , Zhou Yan , Tan Wensong 
Published: September 2023

Abstract
Human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) are widely utilized in the field of regenerative medicine, particularly in cell therapy and tissue engineering. However, their application and development are hindered by limitations in cell expansion efficiency. When hUC-MSCs are cultured in suspension while attached to microcarriers, they tend to aggregate, and adjusting operational parameters fails to resolve the conflict between shear and aggregation. The microenvironment created by the original impeller is not suitable for cell growth. In this study, computational fluid dynamics (CFD) simulations were employed to investigate the flow field structure generated by the original impeller in the commercial spinner flasks. It was found that the flow field structure were unsuitable for the expansion of cells prone to aggregate. Consequently, a new impeller was designed to alter the flow field structure, aimed to promote aggregate suspension while maintaining a similar shear rate at the same rotation speed. Compared to the original impeller, the newly designed impeller demonstrated significant improvements. Notably, it reduced the size of aggregates, increased maximum cell density, and preserved cell stemness during cell expansion. Combining simulation results with experimental data, this study reveals that the degree of suspension of aggregates played a critical role in determining aggregate size. Additionally, the level of cell stemness was determined by modulating shear rate and the degree of aggregate suspension.
Fixation For Calcaneal Tuberosity Fracture (Beak Fracture) Using Preformed "L-shape" Hook Plate
Authors: Zhang Qiang , Wu Zongde 
Published: September 2023

Abstract
Objectives: Treating calcaneal tuberosity fracture (beak fracture) is considered difficult. The ankle functions of patients may be badly affected by skin flap necrosis and/or implant failure. In this study, we propose a robust, facile, economic and safe internal fixation technique to fix the fracture fragments using preformed "L-shape" hook plate.
Methods: A retrospective study is conducted to analyze patients with calcaneal tuberosity fracture who received surgical management from January 2015 to February 2020. According to Beavis classification, all of the patients were categorized into type II with larger fracture fragments, who were treated by internal fixation adopting preformed "L-shape" hook plate. The operation time, complications, and clinical healing time were recorded, Functional assessment is performed according to American Orthopedic Foot and Ankle Society Ankle-Hindfoot (AOFAS-AH) scores and Visual Analog Scale (VAS) pain scores.
Results: There were a total of 15 patients of calcaneal tuberosity fracture (beak fracture), who had been treated by internal fixation adopting preformed "L-shape" hook plate. Among them, six patients were female and the rest were male, with their age ranging from 29 to 69 years (average of 52.9±11.2 years). The mean duration of follow-up was 17.1±6.0 months (range: 12 to 36 months). Eleven patients underwent emergency surgery. After the operation, no complications were observed such as poor wound healing, skin flap necrosis, wound dehiscence, hematomas or infections. In addition, none of the following complications were observed, which involved plate exposure, sural nerve injuries, venous thromboembolic events, loss of reduction, and fixation failure. In this study, fifteen cases achieved clinical healing at 8-13 weeks (average 10.5 weeks) postoperatively. For functional evaluation, the preoperative VAS and AOFAS-AH scores were 5.7±0.6 and 24.0±9.9 respectively, whereas the postoperative VAS and AOFAS-AH scores at the last follow-up were 1.3±0.5 and 93.8±5.2 (p<0.001).
Conclusions: Emergency open reduction and internal fixation operation should be conducted with respect to patients who have calcaneal avulsion fracture, thereby preventing flap necrosis from happening. For patients with Beavis type II beak fracture, preformed "L-shape" hook plate fixation facilitates better recovery of normal ankle functions. Performing as one of the optional treatments, this study proposes a robust, facile, and safe internal fixation technique for avulsion fractures of calcaneal tuberosity (beak fracture ). A series of follow-up case study have verified the validity and effectiveness of implementing the proposed method, paving way for treating complicated calcaneal avulsion fractures.