bluuebunny/crossref_metadata_2025_split huggingface dataset:
Personagens negras de O Cortiço: convergências com estereótipos
Authors: Queiroz Eduardo Prachedes 
Published: December 2022

Sabendo da importante contribuição que podem fazer as análises sólidas para o reconhecimento e o combate ao racismo, desejamos, com o presente artigo, examinar como são construídas três personagens do romance de Aluísio Azevedo, O Cortiço (1890) – Rita Baiana, Bertoleza e Firmo, evidenciando as estratégias discursivas usadas em sua construção e as correspondências dessas personagens com estereótipos negativos reconhecidos na cultura brasileira com relação a pessoas negras. Para alcançar nosso objetivo, analisaremos trechos do romance principalmente fazendo uso de elementos da semântica discursiva, relacionando os resultados das análises com discursos convergentes e divergentes presentes em outros textos a fim de melhor iluminar as questões pertinentes.
O Pão Que O Viado Amassou: contribuições da semiótica para o processamento de língua natural
Authors: Silva Tulio Ferreira Leite da 
Published: December 2022

A crescente produção de dados na internet e nas redes sociais digitais é incontornável e, até 2025, espera-se que a humanidade produza por dia 463 exabytes de dados em geral. A dimensão de tal valor pode ser ilustrada com a imagem de aproximadamente meio trilhão de pendrives de 1 gigabyte. Tal fenômeno, entretanto, longe de ser motivo para comemorações (como querem as Big Techs), tem sido diretamente responsável por inúmeros males à sociedade e à Democracia, sendo o discurso de ódio e a desinformação apenas a ponta do iceberg. Por conta desse cenário alarmante, a realização de pesquisas na interface entre semiótica e tecnologias de processamento de dados se faz urgente. Neste artigo, pretendemos apresentar brevemente o cenário de uma das áreas mais celebradas da Inteligência Artificial (caracterizada pelas redes neurais artificiais) e então utilizar os conceitos de contexto situacional e de competência discursiva para debater os mecanismos de sinalização de discursos enviesados, utilizados para marcar publicações digitais com potencial de desinformação ou de discurso de ódio. Caso icônico ao qual pretendemos nos deter, O Pão Que o Viado Amassou é um delivery curitibano, criado por um gay bem humorado, que foi penalizado pelo Facebook.
Estratégias semânticas no discurso do MEC e ideologia
Authors: Gomes Regina Souza 
Published: December 2022

Este artigo tem como objetivo, à luz da semiótica discursiva, analisar as estratégias semânticas empregadas em textos publicados no site do Ministério da Educação (notícias, documentos, programas, especialmente os voltados para a alfabetização) para colocar em circulação certos valores ideológicos, ao mesmo tempo que, ao se apropriar de temas caros aos discursos com os quais mantêm relações polêmicas, os alteram, distorcem ou subvertem. Buscamos mostrar a ênfase no tema da ciência, como ele é tratado nos textos, quais combinações temáticas são a ele associadas, suas relações interdiscursivas polêmicas e consensuais e, nesse contexto, como a figura do professor é construída. Observou-se que foram operadas triagens, partindo de um regime de exclusão, de modo a restringir o valor da ciência nos discursos governamentais sobre alfabetização, que se associam aos temas da tecnologia, do mercado e da profissionalização. Há também uma divisão de papéis temáticos no que se refere aos atores que estão envolvidos no fazer pedagógico, de modo que os professores são sujeitos operadores das atividades práticas pensadas e elaboradas por “especialistas”, dotados de um saber científico e técnico eficaz.
L’identité narrative en question : les zones paradoxales de l’expérience
Authors: Estay Stange Verónica 
Published: December 2022

Afin de remettre en cause le problème de l’identité collective, le présent essai prend pour objet les discours de la mémoire post-dictature au Chili et en Argentine, dont il souligne les contradictions et les points de fracture. On voudrait montrer ici comment “l’ancrage ontologique” des “rôles thématiques” (héros, militant de la résistance, tyran, tortionnaire), essentiel pour l’engendrement des récits historique et judiciaire, se voit questionné par les micro-récits dévoilant la complexité immanente aux individus qui leur prêtent une concrétude corporelle. Entre collaboration contrainte, dissidence, Syndrome de Stockholm et “honte du survivant”, cet article passe en revue les multiples “instances énonçantes” qui, en amont des acteurs collectifs, nous font problématiser le concept même d’une “identité”, tout en dissociant ses différents domaines de manifestation (historique, juridique, politique, intersubjectif, intime...).
Língua, gênero e diversidade: o que tem a semiótica a ver com isso?
Authors: Schwartzmann Matheus Nogueira 
Published: December 2022

Neste trabalho, objetivamos demostrar como discursos sexistas e sobre a língua são construídos para perpetuar preconceitos de gênero, raça e classe, à medida que o discurso anticientífico é usado para estabelecer a língua normatizada por gramáticas e dicionários como a única correta e aceitável, e performances linguísticas sexistas e intolerantes perpetuam formas de violência contra o corpo feminino (mulheres cis e identidades de gênero LGBTQIA+), e sua consequente exclusão social. Utilizando a visada teórico-metodológica da semiótica discursiva, verificamos a construção figurativa e veridictória do nosso córpus, revelando valores como a negação das transformações da/na língua em uso em artigo jornalístico veiculado na revista Veja em 2001, na Portaria nº 604/21, do Ministério do Turismo, e no Projeto de Lei 948/21, dispositivos legislativos que vetam o uso de linguagem neutra na esfera pública brasileira. Conforme explicitamos como a linguagem sexista inflige a exclusão e violências simbólicas à população que não é exclusivamente masculina, simultaneamente, analisamos o Manual para o uso não sexista da linguagem (2014), publicado pelo Governo do Rio Grande do Sul. Como resultado, apresentamos o que é e como o falante do português pode usar a linguagem não sexista e a linguagem neutra em diferentes situações de interação social.
Abordagens terapêuticas do Condiloma Acuminado em crianças e adolescentes
Authors: Drumond Denise Gasparetti , Castelo Bárbara Bizzo , Esperança Samuel Drumond , Dominiquini Fellipe Bruno , Speck Neila Maria de Góis 
Published: December 2022

Objetivos: A infecção pelo papiloma vírus humano dos tipos 6 e 11 pode evoluir para Condiloma Acuminado. Sua transmissão é principalmente via sexual, de forma que a presença dessas verrugas em crianças deve ser considerada sinal de alarme para investigação de abuso. Eventualmente, contudo, ocorre por autoinoculação ou fômites. O tratamento é desafiador, dado que apesar do extenso arsenal, a recorrência se faz comum. A presente revisão sistemática advém a comparar taxas de sucesso das estratégias terapêuticas, objetivando fornecer substrato para escolha acertada no tratamento da doença em crianças e adolescentes. Métodos: Foi realizada Revisão sistemática baseada no guideline Preferred Report Items for Systematic Reviews and Meta-Analyses (PRISMA), registrada na Plataforma PROSPERO sob identificação CRD42021262090. Resultados: 211 estudos foram encontrados nas databases consultadas, de forma que 30 atenderam as propostas de critérios estabelecidos na pesquisa sistematizada. Esses passaram extração de dados para síntese qualitativa, demonstrando eficácia de métodos não-invasivos a invasivos. Conclusões: Mediante bons resultados em resolução da doença e reduzidos efeitos adversos, a terapia mais popular entre os autores foi o Imiquimode. A pesquisa chamou atenção à necessidade de estudos mais robustos e metodologias mais complexas a cerca das abordagens terapêuticas do Condiloma Acuminado em crianças e adolescentes.
Sex-Specific Survival Bias and Interaction Modeling in Coronary Artery Disease Risk Prediction
Authors: Surakka Ida , Wolford Brooke N. , Ritchie Scott C. , Hornsby Whitney E. , Sutton Nadia R. , Elvenstad Gabrielsen Maiken , Skogholt Anne Heidi , Thomas Laurent , Inouye Michael , Hveem Kristian , Willer Cristen J. 
Published: December 2022

Background:
The 10-year Atherosclerotic Cardiovascular Disease risk score is the standard approach to predict risk of incident cardiovascular events, and recently, addition of coronary artery disease (CAD) polygenic scores has been evaluated. Although age and sex strongly predict the risk of CAD, their interaction with genetic risk prediction has not been systematically examined. This study performed an extensive evaluation of age and sex effects in genetic CAD risk prediction.

Methods:
The population-based Norwegian HUNT2 (Trøndelag Health Study 2) cohort of 51 036 individuals was used as the primary dataset. Findings were replicated in the UK Biobank (372 410 individuals). Models for 10-year CAD risk were fitted using Cox proportional hazards, and Harrell concordance index, sensitivity, and specificity were compared.

Results:
Inclusion of age and sex interactions of CAD polygenic score to the prediction models increased the C-index and sensitivity by accounting for nonadditive effects of CAD polygenic score and likely countering the observed survival bias in the baseline. The sensitivity for females was lower than males in all models including genetic information. We identified a total of 82.6% of incident CAD cases by using a 2-step approach: (1) Atherosclerotic Cardiovascular Disease risk score (74.1%) and (2) the CAD polygenic score interaction model for those in low clinical risk (additional 8.5%).

Conclusions:
These findings highlight the importance and complexity of genetic risk in predicting CAD. There is a need for modeling age- and sex-interaction terms with polygenic scores to optimize detection of individuals at high risk, those who warrant preventive interventions. Sex-specific studies are needed to understand and estimate CAD risk with genetic information.
Genome-Wide Association and Inheritance-Based Analyses Implicate Unconventional Myosin Genes in Hypoplastic Left Heart Syndrome
Authors: Theis Jeanne L. , Shatila Sarah-Dana H. , Fogarty Zachary C. , Bamlet William R. , Olson Timothy M. 
Published: December 2022

Background:
Deciphering hypoplastic left heart syndrome (HLHS) pathogenesis is confounded by its genetic heterogeneity and oligogenic underpinnings.

Methods:

Whole genome sequences were analyzed by 3 independent strategies to identify
HLHS
gene candidates, ranked by variant, gene, and disease-level metrics.

Results:

First, a genome-wide association study of 174 cases and 853 controls revealed suggestive association with a
MYO18B
intron 33 variant (rs2269628-G; frequency=0.55 versus 0.39; OR, 1.97 [95% CI, 1.54–2.52];
P
=6.70×10
−
8
). Second, transmission disequilibrium testing of 161 HLHS proband-parent trios revealed overrepresentation of a
MYO18B
intron 42 variant (rs73154186-A; frequency=0.05; OR, 24 [95% CI, 3.2–177.4];
P
=4.23×10
−
6
). Third, rare, predicted-damaging variants were filtered in 2 multiplex families. In 141H, 2 fifth-degree relatives with HLHS shared a paternally-inherited
MYO5A
missense variant (p.Arg801Trp; frequency=0.00003; combined annotation-dependent depletion score=29), each with a maternally-inherited or de novo candidate modifier variant in a MYO5A-interacting conventional myosin. In 442H, a HLHS proband was compound heterozygous for
MYO15A
variants—a maternally-inherited pathogenic stop-gain variant co-segregating with tetralogy of Fallot and bicuspid aortic valve in maternal relatives (p.Tyr2819Ter; frequency=0.00003) and a paternally-inherited intronic variant altering a canonical transcription factor binding site (rs1277068603; frequency=0.00001; position weight matrix score=0.98).

Conclusions:

Collectively, these findings suggest that common and rare alleles within unconventional myosin genes are associated with HLHS susceptibility. The identified candidate
MYO18B
regulates cardiac sarcomerogenesis, supporting the hypothesis of intrinsic myogenic perturbation in arrested left heart development.
Development of a Hybrid Ensemble–Variational Data Assimilation System over the Western Maritime Continent
Authors: Lee Joshua Chun Kwang , Barker Dale Melvyn 
Published: December 2022

Abstract
A hybrid three-dimensional ensemble–variational (En3D-Var) data assimilation system has been developed to explore incorporating information from an 11-member regional ensemble prediction system, which is dynamically downscaled from a global ensemble system, into a 3-hourly cycling convective-scale data assimilation system over the western Maritime Continent. From the ensemble, there exists small-scale ensemble perturbation structures associated with positional differences of tropical convection, but these structures are well represented only after the downscaled ensemble forecast has evolved for at least 6 h due to spinup. There was also a robust moderate negative correlation between total specific humidity and potential temperature background errors, presumably because of incorrect vertical motion in the presence of clouds. Time shifting of the ensemble perturbations, by using those available from adjacent cycles, helped to ameliorate the sampling error prevalent in their raw autocovariances. Monthlong hybrid En3D-Var trials were conducted using different weights assigned to the ensemble-derived and climatological background error covariances. The forecast fits to radiosonde relative humidity and wind observations were generally improved with hybrid En3D-Var, but in all experiments, the fits to surface observations were degraded compared to the baseline 3D-Var configuration. Over the Singapore radar domain, there was a general improvement in the precipitation forecasts, especially when the weighting toward the climatological background error covariance was larger, and with the additional application of time-shifted ensemble perturbations. Future work involves consolidating the ensemble prediction and deterministic system, by centering the ensemble prediction system on the hybrid analysis, to better represent the analysis and forecast uncertainties.
Increasing occupational participation: A qualitative analysis within the “Occupational Self-Analysis” program
Authors: Fernández-Solano Ana Judit , Rodríguez-Bailón María , Del Baño-Aledo Maria Elena 
Published: December 2022

Introduction: Occupational participation is a key element to increase the quality of life in the population. One of the effective interventions to increase occupational participation is the “Occupational Self-Analysis” program. The aim of this study was to analyze participant’s reported benefits about the “Occupational Self-Analysis” program. Method: This is a qualitative study with 26 participants (12 people with intellectual disability, 7 affected by acquired brain injury, and 7 students) who participated in weekly group sessions and one individual session. The outcomes were measured based on participant diaries and focus group transcriptions. Results: Two main themes emerged: (1) supports for occupational participation and (2) barriers for occupational participation. The thematic analysis of the categories was based on the Model of Human Occupation to increase applicability of the program in occupational therapy practice. Conclusions: The “Occupational Self-Analysis” program allowed participants to increase their knowledge of supports provided for and the barriers against occupational participation.
Migration, Diversity and Development in the Villages in Murshidabad District, West Bengal
Authors: Sk Md Musharuddin 
Published: December 2022

With their significant social and cultural diversities, people live together in villages of Murshidabad district, West Bengal. The densely populated villages have high pressure on resources such as land and the rural labour market. NITI AYOG has reported Murshidabad district as one of the most backward districts in India. International labour migration started in the 1970s following the pilgrimage to Mecca, Saudi Arabia, for better jobs and income. Devastating floods in 2000 accelerated the emigration of labour to the Gulf countries to mitigate the damage. In recent years, especially post-flood time, Hindu neighbours with Muslim counterparts also moved to Gulf countries for better income. Remittances improved villagers’ material conditions (land and housing) and developed the growing local rural market. The knitted social cohesion between Hindus and Muslims initiated and accelerated the emigration process of Hindus, too, later on, further tightening the family and social ties in the post-migration period. This trust and ties of diverse groups have strengthened the potential for creating sustainable societies and attaining several SDGs, specifically SDG 1 (no poverty) and SDG 16 (peace, justice and strong institutions).
Assessment of beneficial fungal microorganism’s bio-efficacy in stimulating morphological and physiological parameters of Allium cepa plants grown in soil amended with fish wastes
Authors: Abdelhameed Reda E. , Metwally Rabab A. 
Published: December 2022

Abstract
Background
The increase in the human consumption of fish results in the production of organic fish wastes (FW). For enhanced soil fertility and plant growth at a lower cost and without the negative impacts of chemical fertilizers, these wastes could be employed as a valuable organic fertilizer. To determine the synergistic bio-efficacy of Trichoderma sp. and arbuscular mycorrhizal (AM) fungi in stimulating the morphological and physiological characteristics of FW-fertilized Alium cepa, as well as to investigate their involvement in boosting soil fertility, the current study was carried out. Overall, eight treatments were applied as follows: AM, Trichoderma sp., AM + Trichoderma sp., FW, AM + FW, Trichoderma sp. + FW, AM + Trichoderma sp. + FW, and control. Growth and physiological assessments of onion plants were taken after 8 weeks from FW application.

Results
Our results showed that FW application combined with AM fungi and Trichoderma sp. inoculations increased aggregate stability of the soil (glomalin content) and soil chitinase activity. Moreover, using the bio-inoculations along with FW amendments significantly (p < 0.05) improved the photosynthetic pigments, protein, carbohydrates, and nutrients content of onion plants. It's interesting to note that the triple interaction of AM + Trichoderma sp. + FW led to the greatest increase in plant height, root length, number of leaves, and leaf area as well as total fresh and dry weights of shoots and roots. Besides, AM fungal colonization was at its highest percentage with Trichoderma sp. inoculation, although this percentage decreased with FW addition.

Conclusion
We concluded that the combined treatments of AM fungi and Trichoderma sp. along with FW application to the soil can be proposed as a successful strategy for plant performance in nutrient-deficient soils as both fungal inoculants are capable of degrading these wastes and converting them into manure suitable for farming so plants can uptake the minerals effortlessly.
Validation of Novel spot blotch disease resistance alleles identified in unexplored wheat (Triticum aestivum L.) germplasm lines through KASP markers
Authors: Kumar Suneel , Pradhan Anjan Kumar , Kumar Uttam , Dhillon Guriqbal Singh , Kaur Satinder , Budhlakoti Neeraj , Mishra Dwijesh Chandra , Singh Amit Kumar , Singh Rakesh , Kumari Jyoti , Kumaran Vikas V. , Mishra Vinod Kumar , Bhati Pradeep Kumar , Das Saikat , Chand Ramesh , Singh Kuldeep , Kumar Sundeep 
Published: December 2022

AbstractBackgroundDuring the last few decades, the diverse sources of resistance, several genes and QTLs for spot blotch resistance have been identified. However, a large set of germplasm lines are still unexplored that have the potential to develop highly resistant wheat cultivars for the target environments. Therefore, the identification of new sources of resistance to spot blotch is essential for breeding programmes to develop spot blotch resistant cultivars and sustain wheat production. The association mapping panel of 294 diverse bread wheat accessions was used to explore new sources of spot blotch disease resistance and to identify genomic regions using genome wide association analysis (GWAS). The genotypes were tested in replicated trials for spot blotch disease at three major hot spots in India (Varanasi in UP, Pusa in Bihar, and Cooch Behar in West Bengal). The area under the disease progress curve (AUDPC) was calculated to assess the level of resistance in each genotype.ResultsA total of 19 highly and 76 moderately resistant lines were identified. Three accessions (EC664204, IC534306 and IC535188) were nearly immune to spot blotch disease. The genotyping of all accessions resulted in a total of 16,787 high-quality polymorphic SNPs. The GWAS was performed using a Compressed Mixed Linear Model (CMLM) and a Mixed Linear Model (MLM). A total of seven significant MTAs, common in both the models and consistent across the environment, were further validated to develop KASP markers. Four MTAs (AX-94710084, AX-94865722, AX-95135556, and AX-94529408) on three chromosomes (2AL, 2BL, and 3BL) have been successfully validated through the KASP marker.ConclusionsThe new source of resistance was identified from unexplored germplasm lines. The genomic regions identified through GWAS were validated through KASP markers. The marker information and the highly resistant sources are valuable resources to rapidly develop immune or near immune wheat varieties.
Development of diagnostic algorithm using machine learning for distinguishing between active tuberculosis and latent tuberculosis infection
Authors: Luo Ying , Xue Ying , Liu Wei , Song Huijuan , Huang Yi , Tang Guoxing , Wang Feng , Wang Qi , Cai Yimin , Sun Ziyong 
Published: December 2022

Abstract
Background
The discrimination between active tuberculosis (ATB) and latent tuberculosis infection (LTBI) remains challenging. The present study aims to investigate the value of diagnostic models established by machine learning based on multiple laboratory data for distinguishing Mycobacterium tuberculosis (Mtb) infection status.

Methods
T-SPOT, lymphocyte characteristic detection, and routine laboratory tests were performed on participants. Diagnostic models were built according to various algorithms.

Results
A total of 892 participants (468 ATB and 424 LTBI) and another 263 participants (125 ATB and 138 LTBI), were respectively enrolled at Tongji Hospital (discovery cohort) and Sino-French New City Hospital (validation cohort). Receiver operating characteristic (ROC) curve analysis showed that the value of individual indicator for differentiating ATB from LTBI was limited (area under the ROC curve (AUC) < 0.8). A total of 28 models were successfully established using machine learning. Among them, the AUCs of 25 models were more than 0.9 in test set. It was found that conditional random forests (cforest) model, based on the implementation of the random forest and bagging ensemble algorithms utilizing conditional inference trees as base learners, presented best discriminative power in segregating ATB from LTBI. Specially, cforest model presented an AUC of 0.978, with the sensitivity of 93.39% and the specificity of 91.18%. Mtb-specific response represented by early secreted antigenic target 6 (ESAT-6) and culture filtrate protein 10 (CFP-10) spot-forming cell (SFC) in T-SPOT assay, as well as global adaptive immunity assessed by CD4 cell IFN-γ secretion, CD8 cell IFN-γ secretion, and CD4 cell number, were found to contribute greatly to the cforest model. Superior performance obtained in the discovery cohort was further confirmed in the validation cohort. The sensitivity and specificity of cforest model in validation set were 92.80% and 89.86%, respectively.

Conclusions
Cforest model developed upon machine learning could serve as a valuable and prospective tool for identifying Mtb infection status. The present study provided a novel and viable idea for realizing the clinical diagnostic application of the combination of machine learning and laboratory findings.