bluuebunny/crossref_metadata_2025_split huggingface dataset:
Examining the integration of artificial intelligence in supply chain management from Industry 4.0 to 6.0: a systematic literature review
Authors: Samuels Alexander 
Published: January 2025

BackgroundThis study examines the integration of Artificial Intelligence (AI) in supply chain management (SCM) during the transition from Industry 4.0 to Industry 6.0. The focus is on improving operational efficiency, promoting human-centric collaboration, and advancing sustainability within supply chains. As industries progress, the need to incorporate AI technologies that improve decision-making and operational resilience while ensuring sustainable practices becomes increasingly critical. This systematic review aims to explore how AI is transforming SCM through these industrial transitions.MethodsUtilising the PRISMA framework, a systematic review was conducted to gather and analyse relevant literature published between 2010 and 2023. A comprehensive search of databases including Web of Science, Scopus, IEEE Xplore, Google Scholar, and ScienceDirect was performed. The review involved rigorous screening for eligibility and thematic analysis using Atlas-ti software to identify key themes and patterns related to AI integration in SCM.ResultsThe findings indicate that AI integration significantly improves SCM by improving demand forecasting, inventory management, and overall decision-making capabilities. Industry 5.0 focuses on human-AI collaboration, improving customisation and problem-solving. AI technologies also contribute to sustainability by optimising resource utilisation and reducing environmental impacts. However, challenges such as cybersecurity risks and workforce skill gaps need to be addressed to fully leverage AI’s potential.ConclusionIntegrating AI in SCM not only improves operational efficiency and sustainability but also promotes resilience against disruptions. The insights from this review offer valuable guidance for both academics and practitioners aiming to optimise supply chain operations through AI technologies from Industry 4.0 to Industry 6.0. The study underlines the importance of a balanced approach that integrates technological developments with human-centric and sustainable practices.
Staphylococcus aureus carriage is associated with microbiome composition in the nares and oropharynx, not the hand, of monozygotic twins
Authors: Dalman Mark R. , Simison W. Brian , Nielsen Danny , Bhatta Sabana , Ramahi Noor , Yee Clair , Thapaliya Dipendra , Kadariya Jhalka , Cheatham Shanice , Olson Hailee , Smith Tara C. 
Published: January 2025

BackgroundStaphylococcus aureus is a gram-positive bacterium commonly found in the nares and oropharynx of one in three individuals and has the potential to cause significant health problems. With antibiotic-resistant strains causing 11,000 deaths yearly and ~2% of the population nasally colonized with methicillin-resistant S. aureus, a search for predictive markers and associative relationships between carriage have been long-sought goals. Within our study, we leveraged monozygotic twin participants in concert with multi-site microbiome analyses to characterize the impacts of S. aureus on composition.ResultsWe recruited 147 monozygotic twin pairs and characterized three sites, i.e., the nares, oropharynx, and hand microbiomes, using 16S rRNA v3-v4 sequencing in addition to S. aureus carriage status. The prevalence of S. aureus was highest in the oropharynx followed by nares and hand with concordance between twin pairs highest in the nares, followed by oropharynx. The detection of S. aureus was statistically correlated with differences in microbiome composition across sites, as indicated by beta diversity and DESeq2 analyses. Microbiome composition was most similar in twins’ nares that were S. aureus culture-positive concordant, whereas twins that were culture-negative concordant had the most similarity in the oropharynx. Of significance, Moraxella nonliquefacians and Capnocytophaga were inversely associated with S. aureus in the nares and oropharynx, respectively.ConclusionsThis improved understanding of S. aureus colonization in nares, oropharynx, and hand microbiomes in monozygotic twin pairs is a further step towards unraveling the degree to which the microbiome is influenced by host genetics and S. aureus carriage.
The key roles of teammates, coaches, and instrumental support in adolescent sports participation: a one-year prospective study
Authors: Spruijtenburg Gwennyth E. , van Abswoude Femke , Platvoet Sebastiaan W. J. , de Niet Mark , Steenbergen Bert 
Published: January 2025

IntroductionSports participation is important for promoting lifelong health and well-being. However, it often declines during adolescence, highlighting the need to understand the factors related to adolescent sports participation. This prospective study examines the associations between different sources (e.g., family, peers, coaches, teachers) and types (e.g., emotional, instrumental, co-participation) of social support and hours of organized sports participation among secondary school students (N = 294). It also explores whether these associations change from the second to the third year of secondary education.MethodsData were collected using questionnaires and anthropometric measurements in October/November 2021 and October/November 2022. Multilevel linear fixed effects regression models were used to analyze relationships between sources and types of social support and sports participation. Additionally, scatterplots illustrated individual variability in these associations.ResultsResults showed significant associations for various sources and types of social support with organized sports participation. Social support from teammates and coaches and instrumental support emerged as the strongest predictors of hours of participation. Additionally, we found that the relationships remained stable over time. Yet, substantial individual variability in how social support related to sports participation was also observed.DiscussionThese findings emphasize the importance to promote social support from within the sports environment and to encourage instrumental support. Tailored approaches addressing individual differences are recommended to enhance adolescent sports participation.
Real-life effectiveness and safety of baricitinib in 17 Japanese patients with alopecia areata: a 60-week single center study
Authors: Uchiyama Akihiko , Araki Takeshi , Kosaka Keiji , Motegi Sei-Ichiro 
Published: January 2025

Alopecia areata (AA) is a chronic immune-mediated skin disorder characterized by non-scarring hair loss. Although clinical trials have shown the effectiveness and safety of baricitinib, there are limited reports that have shown real-world evidence of baricitinib in patients with AA. Herein, we present the real-world data of 17 Japanese adult patients with AA treated with baricitinib at Gunma University Hospital, Japan, for 60 weeks. All patients received 4 mg of baricitinib daily without interruption. The SALT20 achievement was 29.4% (5/17) at week 24, 52.9% (9/17) at week 36, 58.9% (11/17) at week 48, and 64.7% (11/17) at week 60. Patients were categorized as early responders (n = 1), gradual responders (n = 8), late responders (n = 3), and non-responders (n = 5). Exacerbations of alopecia occurred in only one patient. Eleven patients experienced improvement in scalp hair loss at week 12, leading to a significant reduction in the AA-IGA score. At week 24, improvements in eyebrows and eyelashes were noted in 12 and 11 patients, respectively, with significant reductions in their ClinRO scores. The duration of the current episode of AA exceeding 4 years significantly reduced the SALT20 achievement rate (p &lt; 0.027). Common adverse effects included acne (n = 4, 23.5%) and mildly decreased renal function (n = 2, 11.7%). In conclusion, our findings indicate that baricitinib has significant potential for improving intractable severe AA.
Soil Degradation Evidence Following a Wildfire in Arequipa’s Andean Region, Peru
Authors: Coaguila Lunsden , Mataix-Solera Jorge , Nina Sonia , García-Carmona Minerva , Salazar Elizabeth T. 
Published: January 2025

Fire is a natural ecological force, but its effects vary significantly depending on the ecosystem. While fire-adapted ecosystems, such as Mediterranean woodlands, recover quickly, non-fire adapted regions like the Peruvian Andes are highly vulnerable to soil degradation, especially with increasing wildfire frequency and intensity due to climate change. The study investigates the effects of a 2018 wildfire in the Pichu Pichu volcano mountain area, a shrubland ecosystem at 3,700 m a.s.l. The arid conditions and unique soil characteristics, such as the Torripsamment soil on volcaniclastic sandstones, make the area particularly vulnerable to fire-induced degradation. Soils were evaluated three and 4 years after the fire event under two key dominant plant species in the ecosystem: Berberis lutea and Parastrephia quadrangularis. The results show that the combined fire and post-fire erosion processes significantly impacted soil properties, leading to a loss of soil organic carbon (SOC), increased bulk density (BD), loss of soil structure and, in the second sampling, a strong reduction in clay content attributable to weak aggregation and erosive processes. Soils under Berberis exhibited greater SOC losses, likely due to its larger biomass that intensified the combustion effects. The decrease in SOC resulted in soil compaction. Water repellency (WR), a natural feature in these soils due to the high sand content, remained largely unaffected by the fire. However, the persistence of WR may hinder water infiltration, increasing surface runoff and erosion, especially in the absence of vegetation post-fire. The findings highlight the fragility of these Andean soils to fire events, contrasting with the resilience that Mediterranean ecosystems often display. This lack of recovery underscores the need for improved wildfire prevention and post-fire soil management strategies, particularly as climate change further exacerbates the risks of soil degradation due to reduced water availability and more frequent fires in these fragile arid ecosystems.
Effects of Lutjanus erythropterus Protein on Depression-like Behavior and Gut Microbiota in Stressed Juvenile Mice
Authors: Luo Jinjin , Wang Chen , Ye Weichang , He Ruiyang , Huang Ling , Fang Zhijia , Deng Qi , Qiu Mei , Sun Lijun , Gooneratne Ravi 
Published: January 2025

Lutjanus erythropterus protein (Lep) exhibits anti-inflammatory effects, but its antidepressant activity is unknown. This study used a 44-day chronic unpredictable mild stress (CUMS) model to determine whether Lep has a beneficial effect through the gut–brain axis in 3-week-old male C57BL/6 mice. Gavaging with Lep solution alleviated the depression-like behavior and anxiety symptoms in CUMS growing mice. Administration of Lep decreased serum IL-1β, IL-2, IL-6, and TNF-α levels and restored colonic mucosal damage. In addition, Lep improved the disturbance of 5-hydroxytryptamine (5-HT) secretion in the gut–brain axis. Pearson analysis revealed that gut short-chain fatty acid (SCFAs) concentration significantly (p < 0.05) correlated with mucosal damage scores and the depression-like behavior index. Lep was able to prevent the gut SCFA enrichment. Lep upregulated gut Muribaculaceae and downregulated SCFA-producing bacteria by replenishing deficient amino acid (AA) (tryptophan, alanine, aspartate, glutamate) and decreased (p < 0.01) the gene abundance of the AA metabolism pathway of SCFA-producing bacteria, thereby preventing gut SCFA enrichment and alleviating associated depression-like behavior. These findings indicate that Lep could attenuate depression in CUMS juvenile mice via the gut microbiota-SCFA–brain axis.
Prevalence and Antibiotic Resistance of Escherichia coli Isolated from Raw Cow’s Milk
Authors: Drugea Roxana Ionela , Siteavu Mădălina Iulia , Pitoiu Elena , Delcaru Cristina , Sârbu Ecaterina Monica , Postolache Carmen , Bărăităreanu Stelian 
Published: January 2025

Escherichia coli (E. coli) is one of the most common pathogens in both humans and livestock. This study aimed to investigate the prevalence of E. coli isolated from raw cow milk and evaluate its antimicrobial resistance rates. A total of 1696 milk samples were collected from Romanian dairy farms from 2018 to 2022. E. coli was isolated on various selective agar media, such as Cled agar and Columbia Agar with 5% Sheep Blood. The identification of E. coli was performed by MALDI-TOF MS. E. coli isolates were tested for their susceptibility against 18 commonly used antibiotics in a disk diffusion method. The overall prevalence of E. coli was 22.45% of all isolated pathogens. Antibiogram analysis revealed that 27.51% of E. coli isolates from milk were multidrug-resistant. Resistance was highest for penicillin–novobiocin (87.78%), followed by streptomycin (53.7%). Resistance to six drugs (amoxicillin, streptomycin, kanamycin–cephalexin, marbofloxacin, ampicillin) showed a significant increasing trend over time, while for two drugs (penicillin G-framycetin, doxycycline), a significant decrease was observed. Our results suggest that milk can be a reservoir of bacteria with the potential for infection in humans via the food chain. Furthermore, there is a need for surveillance and monitoring to control the increase in resistance to currently used antimicrobials in dairy farms because the occurrence of multidrug-resistant E. coli isolated from milk poses a health hazard to consumers.
Spirulina Supplementation Alleviates Intense Exercise-Induced Damage and Modulates Gut Microbiota in Mice
Authors: Wang Chunxia , Liu Huijuan , Zhang Shuyu , Ren Chengyi , Xu Jiaming , Chen Juanjuan , Chen Haimin , Wu Wei 
Published: January 2025

Background: Spirulina, which are filamentous cyanobacteria, have gained significant popularity in the food industry, medicine, and aquaculture. Methods: In this study, our objective was to explore the influence of Spirulina on the gut microbiota and exercise capacity of mice undergoing high-intensity exercise. Twenty-four male BALB/c mice were divided into four groups, with six mice in each group. These groups included the control group (Control, in which the mice received saline gavage and were permitted free movement), the exercise group (Running, in which the mice were gavaged with the same volume of saline and subjected to a structured exercise regimen), and the Spirulina intervention groups (including Spirulina Low and Spirulina High). In the Spirulina intervention groups, the mice were orally administered with Spirulina at doses of 100 and 300 mg/kg/day for four weeks while simultaneously participating in the exercise protocol. Results: The results illustrated that the Running group mice subjected to intense exercise exhibited reduced weight and tension, acute damage to muscle and liver tissues, oxidative stress, and an imbalance in the gut microbiota compared with that of the Control group. However, high-concentration Spirulina supplementation was found to increase the tensile strength of the exercise mice by 1.27 ± 0.19 fold (p < 0.05) and ameliorate muscle and liver damage. In the Spirulina High group, the levels of certain indicators related to muscle oxidative stress, including reactive oxygen species, total superoxide dismutase, and catalase, were decreased by 39 ± 5.32% (p < 0.01) and increased by 1.11 ± 0.17 fold and 1.19 ± 0.22 fold (p < 0.01) compared to the Running group. Additionally, a correlation analysis reveals that the alterations in gut microbiota induced by Spirulina might be associated with the indicators of tension and oxidative stress. Conclusions: Collectively, these findings point to the fact that Spirulina can effectively mitigate the acute damage to muscles and the liver induced by intense exercise in mice by enhancing antioxidant capacity and regulating the gut microbiota, thereby providing novel insights into the mechanism underlying the enhancement of exercise function.
Molecular Mechanisms Underlying Neuroinflammation Intervention with Medicinal Plants: A Critical and Narrative Review of the Current Literature
Authors: Barbalho Sandra Maria , Leme Boaro Beatriz , da Silva Camarinha Oliveira Jéssica , Patočka Jiří , Barbalho Lamas Caroline , Tanaka Masaru , Laurindo Lucas Fornari 
Published: January 2025

Neuroinflammation is a key factor in the progression of neurodegenerative diseases, driven by the dysregulation of molecular pathways and activation of the brain’s immune system, resulting in the release of pro-inflammatory and oxidative molecules. This chronic inflammation is exacerbated by peripheral leukocyte infiltration into the central nervous system. Medicinal plants, with their historical use in traditional medicine, have emerged as promising candidates to mitigate neuroinflammation and offer a sustainable alternative for addressing neurodegenerative conditions in a green healthcare framework. This review evaluates the effects of medicinal plants on neuroinflammation, emphasizing their mechanisms of action, effective dosages, and clinical implications, based on a systematic search of databases such as PubMed, SCOPUS, and Web of Science. The key findings highlight that plants like Cleistocalyx nervosum var. paniala, Curcuma longa, Cannabis sativa, and Dioscorea nipponica reduce pro-inflammatory cytokines (TNF-α, IL-6, and IL-1β), inhibit enzymes (COX-2 and iNOS), and activate antioxidant pathways, particularly Nrf2. NF-κB emerged as the primary pro-inflammatory pathway inhibited across studies. While the anti-inflammatory potential of these plants is significant, the variability in dosages and phytochemical compositions limits clinical translation. Here, we highlight that medicinal plants are effective modulators of neuroinflammation, underscoring their therapeutic potential. Future research should focus on animal models, standardized protocols, and safety assessments, integrating advanced methodologies, such as genetic studies and nanotechnology, to enhance their applicability in neurodegenerative disease management.
Study of the chromium oxide and zirconium dioxide additives effect on the properties of pressed high­alumina refractories
Authors: Galchenko T. G. , Shulyk I. G. , Martynenko V. V. , Prymachenko V. V. , Protsak O. B. 
Published: January 2025

This article presents the results of research aimed at studying the effect of chromium oxide and zirconium dioxide refractory additives, the method of their introduction — with separate introduction of each of them or with their joint introduction, as well as with the joint introduction of these additives and the additional introduction of dispersed active alumina A α­form additive, on the main properties (primarily cold crushing strength and thermal shock resistance) of pressed high­alumina refractories.
Comparative studies of the effect of additives of 5 % Cr2O3, 3 % ZrO2, 5 % Cr2O3 and 3 % ZrO2, 10 % Cr2O3 and 3 % ZrO2, 10 % Cr2O3 and 3 % ZrO2, and B % dispersed active alumina A of α­form on the apparent density of unfired samples and their property indicators after firing at a temperature of 1580 ºС were carried out. The optimum composition of the additive (10 % Cr2O3 and 3 % ZrO2 and B % dispersed active alumina A of α­form) was determined, which ensures the production of fired samples with a set of high property indicators: content of Al2O3 86.50—86.70 wt. %, Cr2O3 9.85 wt. %, ZrO2 3.0 wt. %, Fe2O3 0.3 wt. %; apparent density 3.14 g/cm3; open porosity 23 %; cold crushing strength 118 N/mm2; thermal shock resistance (1300 ºС — water) not less than 7 heat changes. The research was the basis for developing the technology of pressed alumina­chromium oxide refractories, for the composition of which an application for the invention was filed and a patent of Ukraine was obtained. The developed technology ensures the production of these products with a cold crushing strength that is ~ 2 times higher and ~ 1.8 times higher thermal shock resistance (in the 1300 ºС water regime) compared to similar characteristics of refractories of the same composition but without the additive.
Based on the research results, regulatory documentation was developed, and the range of competitive refractory products manufactured by the Institute was expanded.
Dependence of the properties of alumina­zirconia­silica refractories on the type of aggregate and the amount of zirconia and silica additives
Authors: Mishnyova Yu. Ye. , Shulyk I. G. , Martynenko V. V. , Krakhmal Yu. O. 
Published: January 2025

JSC “URIR named after A. S. Berezhnoy” has developed the vibrocasting of refractories and manufactures high­quality competitive products, including high­refractory crucibles of various compositions for induction melting of heat­resistant alloys and steels. The most widespread among them are high alumina crucibles, which use fused corundum or corundum and mullite powders as a filler and α­form alumina as a fine­dispersed binder. Based on their composition, alumina­zirconia­silica refractories (AZS) with a content of 10 % ZrO2, which have a filler in the form of fused corundum and mullite, and a fine­dispersed binder — α­form alumina and zircon, were developed.
The influence of aggregate type and zircon and silica additives amount on the properties of vibrocast alumina­zirconia­silica (AZS) refractories with a content of 10—22 % ZrO2 was studied.
The possibility of complete replacement of fused corundum and mullite with tabular alumina in the granular component of the batch, and with alumina, zircon and quartz sand in the fine component in the manufacture of vibrocast AZS refractories with a content of 10 % ZrO2 or with alumina and zircon in the manufacture of vibrocast AZS refractories with a content of 16—22 % ZrO2 was established.
The highest values of properties are observed in alumina­zirconia­silica samples with a content of 10 % ZrO2, which contain tabular alumina (55 %), alumina (22 %), zircon (16 %) and quartz sand (7 %), namely: apparent density 3.05 g/cm3, open porosity 15.6 %, cold crushing strength 195 N/mm2, thermal shock resistance (1300 ºС — water) > 20 heat changes.
Based on the research results, the technology of vibro­cast alumina­zirconia­silica refractories was improved and the raw material base for manufacturing products was expanded.