bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inter-colony and inter-annual variation in discard use by albatross chicks revealed using isotopes and regurgitates
Authors: Kuepfer Amanda , Catry Paulo , Bearhop Stuart , Sherley Richard B. , Bell Olivia , Newton Jason , Brickle Paul , Arkhipkin Alexander , Votier Stephen C. 
Published: March 2023

AbstractEffective marine ecosystem monitoring is critical for sustainable management. Monitoring seabird diets can convey important information on ecosystem health and seabird–fishery interactions. The diet of breeding black-browed albatross (Thalassarche melanophris) has previously been assessed using stomach content analysis (SCA) or stable isotope analysis (SIA), but not both methods together. Combining dietary sampling approaches reduces biases associated with using single methods. This study combines SCA and SIA to study the diet of black-browed albatross chicks, with a specific focus on fishery discard consumption, at two Falkland Islands colonies (New Island 51°43′S, 61°18′W and Steeple Jason Island 51°01′S, 61°13′W) during two consecutive breeding seasons (2019 and 2020). SCA provided high taxonomic resolution of short-term diet and priors for stable isotope mixing models, with multiple measures of dietary items (e.g. numeric frequency N%, frequency of occurrence FO%). By contrast, SIA of down feathers provided a single and more integrated dietary signal from throughout chick development. Although the two methods disagreed on the dominant prey group (SCA—crustacean; SIA—pelagic fish), the complementary information suggested a chick diet dominated by natural prey (SCA: 74%–93% [FO], 44%–98% [N]; SIA: minimum 87%–95% contribution). Nonetheless, SCA revealed that a high proportion of breeding adults do take discards. We detected consistent colony-specific diets in relation to prey species, but not in relation to higher discard use. Overall, discard consumption was highest in 2020, the year characterised by the poorest foraging conditions. Our results have implications for fisheries management and future dietary studies assessing discard use.
Exploration of thyroglobulin as a biomarker of iodine status in iodine-sufficient and mildly iodine-deficient pregnant women
Authors: Dineva Mariana , Rayman Margaret P. , Levie Deborah , Hunziker Sandra , Guxens Mònica , Peeters Robin P. , Murcia Mario , Rebagliato Marisa , Irizar Amaia , Jimeno-Romero Alba , Sunyer Jordi , Korevaar Tim I. M. , Bath Sarah C. 
Published: March 2023

Abstract
Purpose
Urinary iodine-to-creatinine ratio (UI/Creat) reflects recent iodine intake but has limitations for assessing habitual intake. Thyroglobulin (Tg) concentration, which increases with thyroid size, appears to be an indicator of longer-term iodine status in children and adults, however, less is known in pregnancy. This study investigated the determinants of serum-Tg in pregnancy and its use as an iodine-status biomarker in settings of iodine-sufficiency and mild-to-moderate deficiency.

Methods
Stored blood samples and existing data from pregnant women from the Netherlands-based Generation R (iodine-sufficient) and the Spain-based INMA (mildly-to-moderately iodine-deficient) cohorts were used. Serum-Tg and iodine status (as spot-urine UI/Creat) were measured at median 13 gestational weeks. Using regression models, maternal socio-demographics, diet and iodine-supplement use were investigated as determinants of serum-Tg, as well as the association between UI/Creat and serum-Tg.

Results
Median serum-Tg was 11.1 ng/ml in Generation R (n = 3548) and 11.5 ng/ml in INMA (n = 1168). When using 150 µg/g threshold for iodine deficiency, serum-Tg was higher in women with UI/Creat < 150 vs ≥ 150 µg/g (Generation R, 12.0 vs 10.4 ng/ml, P = 0.010; INMA, 12.8 vs 10.4 ng/ml, P < 0.001); after confounder adjustment, serum-Tg was still higher when UI/Creat < 150 µg/g (regression coefficients: Generation R, B = 0.111, P = 0.050; INMA, B = 0.157, P = 0.010). Iodine-supplement use and milk intake were negatively associated with serum-Tg, whereas smoking was positively associated.

Conclusion
The association between iodine status and serum-Tg was stronger in the iodine-deficient cohort, than in the iodine-sufficient cohort. Serum-Tg might be a complementary (to UI/Creat) biomarker of iodine status in pregnancy but further evidence is needed.
Ganglioglioma with adverse clinical outcome and atypical histopathological features were defined by alterations in PTPN11/KRAS/NF1 and other RAS-/MAP-Kinase pathway genes
Authors: Hoffmann Lucas , Coras Roland , Kobow Katja , López-Rivera Javier A. , Lal Dennis , Leu Costin , Najm Imad , Nürnberg Peter , Herms Jochen , Harter Patrick N. , Bien Christian G. , Kalbhenn Thilo , Müller Markus , Pieper Tom , Hartlieb Till , Kudernatsch Manfred , Hamer Hajo , Brandner Sebastian , Rössler Karl , Blümcke Ingmar , Jabari Samir 
Published: March 2023

AbstractExome-wide sequencing studies recently described PTPN11 as a novel brain somatic epilepsy gene. In contrast, germline mutations of PTPN11 are known to cause Noonan syndrome, a multisystem disorder characterized by abnormal facial features, developmental delay, and sporadically, also brain tumors. Herein, we performed a deep phenotype-genotype analysis of a comprehensive series of ganglioglioma (GG) with brain somatic alterations of the PTPN11/KRAS/NF1 genes compared to GG with common MAP-Kinase signaling pathway alterations, i.e., BRAFV600E. Seventy-two GG were submitted to whole exome sequencing and genotyping and 84 low grade epilepsy associated tumors (LEAT) to DNA-methylation analysis. In 28 tumours, both analyses were available from the same sample. Clinical data were retrieved from hospital files including disease onset, age at surgery, brain localization, and seizure outcome. A comprehensive histopathology staining panel was available in all cases. We identified eight GG with PTPN11 alterations, copy number variant (CNV) gains of chromosome 12, and the commonality of additional CNV gains in NF1, KRAS, FGFR4 and RHEB, as well as BRAFV600E alterations. Histopathology revealed an atypical glio-neuronal phenotype with subarachnoidal tumor spread and large, pleomorphic, and multinuclear cellular features. Only three out of eight patients with GG and PTPN11/KRAS/NF1 alterations were free of disabling-seizures 2 years after surgery (38% had Engel I). This was remarkably different from our series of GG with only BRAFV600E mutations (85% had Engel I). Unsupervised cluster analysis of DNA methylation arrays separated these tumours from well-established LEAT categories. Our data point to a subgroup of GG with cellular atypia in glial and neuronal cell components, adverse postsurgical outcome, and genetically characterized by complex alterations in PTPN11 and other RAS-/MAP-Kinase and/or mTOR signaling pathways. These findings need prospective validation in clinical practice as they argue for an adaptation of the WHO grading system in developmental, glio-neuronal tumors associated with early onset focal epilepsy.
The evolution of diagnosis from symptom onset to death in progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) compared to Parkinson’s disease (PD)
Authors: Swallow Diane M. A. , Counsell Carl E. 
Published: March 2023

Abstract
Background
Misdiagnosis and delayed diagnosis in progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) are common. Few studies have systematically evaluated the diagnostic process from symptom onset to death in representative cohorts.

Methods
All PSP/CBD cases (n = 28/2) and age-sex matched Parkinson’s disease (PD) cases (n = 30) were identified from a UK prospective incident Parkinsonism cohort. Medical and research records were reviewed to compare median times from first index symptom to key diagnostic milestones and the nature/timing of secondary care referral and review.

Results
Index symptoms were similar apart from more tremor in PD (p < 0.001) and more impaired balance (p = 0.008) and falls (p = 0.004) in PSP/CBD. PD was diagnosed a median 0.96 years after index symptom. In PSP/CBD the median times from index symptom to identifying parkinsonism and then including PSP/CBD in the differential diagnosis and the final diagnosis were 1.88, 3.41 and 4.03 years, respectively (all p < 0.001). Survival from symptom onset in PSP/CBD and PD was not significantly different (5.98 vs 6.85 years, p = 0.72). More diagnoses (p < 0.001) were considered in PSP/CBD. Prior to diagnosis, PSP/CBD patients had more recurrent emergency attendances (33.3% vs 10.0%, p = 0.01) and were referred to more specialities than PD (median 5 vs 2). Time to any outpatient referral (0.70 vs 0.03 years, p = 0.025) and to specialist movement disorder review (1.96 vs 0.57 years, p = 0.002) was longer in PSP/CBD.

Conclusions
The duration and complexity of the diagnostic journey were greater in PSP/CBD than age-sex matched PD but can be improved. In this older cohort, there was little difference in survival from symptom onset in PSP/CBD and age-sex matched PD.
Differences among a Portuguese cohort of BRCA pathogenic/likely pathogenic variants carriers choosing risk-reducing mastectomy or intensive breast surveillance
Authors: Torres Sandra , Peleteiro Bárbara , Magalhães André , Garrido Luzia , Costa Susy , Fougo José Luís 
Published: March 2023

Abstract
Purpose
Women with BRCA1 and BRCA2 (BRCA1/2) pathogenic/likely pathogenic (P/LP) variants have a higher risk to develop breast and ovarian cancer. In structured high-risk clinics, risk-reducing measures are adopted. This study aimed at characterizing these women and identify factors that may have influenced their choice between risk reduction mastectomy (RRM) and intensive breast surveillance (IBS).

Methods
This study reviewed retrospectively 187 clinical records of affected and unaffected women with P/LP variants of the BRCA1/2 genes, from 2007 to 2022, of which 50 chose RRM, while 137 chose IBS. The research focused on personal and family history and tumor characteristics and their relation with the preventive option chosen.

Results
Among women with personal history of breast cancer, a higher proportion opted for RRM compared to those asymptomatic (34.2% vs 21.3%, p = 0.049), with younger age determining the option for RRM (38.5 years vs 44.0 years, p < 0.001). Among women with personal history of ovarian cancer, a higher proportion opted for RRM compared to those without that history (62.5% vs 25.1%, p = 0.033), with younger age determining the option for RRM (42.6 years vs 62.7 years, p = 0.009). Women who had bilateral salpingo-oophorectomy were more likely to choose RRM than those who did not (37.3% vs 18.3%, p = 0.003). Family history was not associated with preventive option (33.3% vs 25.3, p = 0.346).

Conclusions
The decision for the preventive option is multifactorial. In our study, personal history of breast or ovarian cancer, younger age at diagnosis, and previous bilateral salpingo-oophorectomy were associated with the choice of RRM. Family history was not associated with the preventive option.
Max-3-Lin Over Non-abelian Groups with Universal Factor Graphs
Authors: Bhangale Amey , Stanković Aleksa 
Published: March 2023

AbstractThe factor graph of an instance of a constraint satisfaction problem with n variables and m constraints is the bipartite graph between [m] and [n] describing which variable appears in which constraints. Thus, an instance of a CSP is completely determined by its factor graph and the list of predicates. We show optimal inapproximability of Max-3-LIN over non-Abelian groups (both in the perfect completeness case and in the imperfect completeness case), even when the factor graph is fixed. Previous reductions which proved similar optimal inapproximability results produced factor graphs that were dependent on the input instance. Along the way, we also show that these optimal hardness results hold even when we restrict the linear equations in the Max-3-LIN instances to the form $$x\cdot y\cdot z = g$$

x
·
y
·
z
=
g

, where x, y, z are the variables and g is a group element. We use representation theory and Fourier analysis over non-Abelian groups to analyze the reductions.
Port-metriplectic neural networks: thermodynamics-informed machine learning of complex physical systems
Authors: Hernández Quercus , Badías Alberto , Chinesta Francisco , Cueto Elías 
Published: March 2023

AbstractWe develop inductive biases for the machine learning of complex physical systems based on the port-Hamiltonian formalism. To satisfy by construction the principles of thermodynamics in the learned physics (conservation of energy, non-negative entropy production), we modify accordingly the port-Hamiltonian formalism so as to achieve a port-metriplectic one. We show that the constructed networks are able to learn the physics of complex systems by parts, thus alleviating the burden associated to the experimental characterization and posterior learning process of this kind of systems. Predictions can be done, however, at the scale of the complete system. Examples are shown on the performance of the proposed technique.
Deformable registration of multimodal retinal images using a weakly supervised deep learning approach
Authors: Martínez-Río Javier , Carmona Enrique J. , Cancelas Daniel , Novo Jorge , Ortega Marcos 
Published: March 2023

AbstractThere are different retinal vascular imaging modalities widely used in clinical practice to diagnose different retinal pathologies. The joint analysis of these multimodal images is of increasing interest since each of them provides common and complementary visual information. However, if we want to facilitate the comparison of two images, obtained with different techniques and containing the same retinal region of interest, it will be necessary to make a previous registration of both images. Here, we present a weakly supervised deep learning methodology for robust deformable registration of multimodal retinal images, which is applied to implement a method for the registration of fluorescein angiography (FA) and optical coherence tomography angiography (OCTA) images. This methodology is strongly inspired by VoxelMorph, a general unsupervised deep learning framework of the state of the art for deformable registration of unimodal medical images. The method was evaluated in a public dataset with 172 pairs of FA and superficial plexus OCTA images. The degree of alignment of the common information (blood vessels) and preservation of the non-common information (image background) in the transformed image were measured using the Dice coefficient (DC) and zero-normalized cross-correlation (ZNCC), respectively. The average values of the mentioned metrics, including the standard deviations, were DC = 0.72 ± 0.10 and ZNCC = 0.82 ± 0.04. The time required to obtain each pair of registered images was 0.12 s. These results outperform rigid and deformable registration methods with which our method was compared.
Limiting embeddings of Besov-type and Triebel-Lizorkin-type spaces on domains and an extension operator
Authors: Gonçalves Helena F. , Haroske Dorothee D. , Skrzypczak Leszek 
Published: March 2023

AbstractIn this paper, we study limiting embeddings of Besov-type and Triebel-Lizorkin-type spaces, $$\text {id}_\tau : {B}_{p_1,q_1}^{s_1,\tau _1}(\Omega ) \hookrightarrow {B}_{p_2,q_2}^{s_2,\tau _2}(\Omega )$$

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is a bounded domain, obtaining necessary and sufficient conditions for the continuity of $$\text {id}_\tau $$

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. This can also be seen as the continuation of our previous studies of compactness of the embeddings in the non-limiting case. Moreover, we also construct Rychkov’s linear, bounded universal extension operator for these spaces.
A criterion space decomposition approach to generalized tri-objective tactical resource allocation
Authors: Fotedar Sunney , Strömberg Ann-Brith , Almgren Torgny , Cedergren Stefan 
Published: March 2023

AbstractWe present a tri-objective mixed-integer linear programming model of the tactical resource allocation problem with inventories, called the generalized tactical resource allocation problem (GTRAP). We propose a specialized criterion space decomposition strategy, in which the projected two-dimensional criterion space is partitioned and the corresponding sub-problems are solved in parallel by application of the quadrant shrinking method (QSM) (Boland in Eur J Oper Res 260(3):873–885, 2017) for identifying non-dominated points. To obtain an efficient implementation of the parallel variant of the QSM we suggest some modifications to reduce redundancies. Our approach is tailored for the GTRAP and is shown to have superior computational performance as compared to using the QSM without parallelization when applied to industrial instances.
Shake-table testing of a stone masonry building aggregate: overview of blind prediction study
Authors: Tomić I. , Penna A. , DeJong M. , Butenweg C. , Correia A. A. , Candeias P. X. , Senaldi I. , Guerrini G. , Malomo D. , Wilding B. , Pettinga D. , Spanenburg M. , Galanakis N. , Oliver S. , Parisse F. , Marques R. , Cattari S. , Lourenço P. B. , Galvez F. , Dizhur D. , Ingham J. M. , Ramaglia G. , Lignola G. P. , Prota A. , AlShawa O. , Liberatore D. , Sorrentino L. , Gagliardo R. , Godio M. , Portioli F. , Landolfo R. , Solarino F. , Bianchini N. , Ciocci M. P. , Romanazzi A. , Aşıkoğlu A. , D’Anna J. , Ramirez R. , Romis F. , Marinković M. , Đorđević F. , Beyer K. 
Published: March 2023

AbstractCity centres of Europe are often composed of unreinforced masonry structural aggregates, whose seismic response is challenging to predict. To advance the state of the art on the seismic response of these aggregates, the Adjacent Interacting Masonry Structures (AIMS) subproject from Horizon 2020 project Seismology and Earthquake Engineering Research Infrastructure Alliance for Europe (SERA) provides shake-table test data of a two-unit, double-leaf stone masonry aggregate subjected to two horizontal components of dynamic excitation. A blind prediction was organized with participants from academia and industry to test modelling approaches and assumptions and to learn about the extent of uncertainty in modelling for such masonry aggregates. The participants were provided with the full set of material and geometrical data, construction details and original seismic input and asked to predict prior to the test the expected seismic response in terms of damage mechanisms, base-shear forces, and roof displacements. The modelling approaches used differ significantly in the level of detail and the modelling assumptions. This paper provides an overview of the adopted modelling approaches and their subsequent predictions. It further discusses the range of assumptions made when modelling masonry walls, floors and connections, and aims at discovering how the common solutions regarding modelling masonry in general, and masonry aggregates in particular, affect the results. The results are evaluated both in terms of damage mechanisms, base shear forces, displacements and interface openings in both directions, and then compared with the experimental results. The modelling approaches featuring Discrete Element Method (DEM) led to the best predictions in terms of displacements, while a submission using rigid block limit analysis led to the best prediction in terms of damage mechanisms. Large coefficients of variation of predicted displacements and general underestimation of displacements in comparison with experimental results, except for DEM models, highlight the need for further consensus building on suitable modelling assumptions for such masonry aggregates.
Echocardiographic follow-up after cardiac rehabilitation designed for patients with obesity
Authors: Snelder Sanne M. , den Uijl Iris , Sunamura Madoka , Zijlstra Felix , ter Hoeve Nienke , van Dalen Bas M. 
Published: March 2023

AbstractWe hypothesize that a novel tailor-made cardiac rehabilitation (CR) program for obesity patients (OPTICARE XL) has better outcomes as compared to usual CR regarding parameters of cardiac function as measured by conventional and advanced transthoracic echocardiography. This is an open-label, randomized controlled trial. Inclusion criteria were: patients referred to CR with a body mass index (BMI) ≥30 kg/m2, and age ≥18 years with either coronary artery disease or nonvalvular atrial fibrillation. The experimental group participated in OPTICARE XL and the controls received the usual CR. Subjects randomized to OPTICARE XL received on top of usual CR behavioural therapy for a healthy diet and an active lifestyle for the first 12 weeks. Also, the exercise program was more tailored. Furthermore, a behavioural after-care program was organized with 6 meetings between weeks 13-52. Transthoracic (speckle tracking) echocardiography was performed at baseline and one-year follow-up. A total of 42 patients completed the follow-up, 21 in both groups. There was a mild but statistically significant reduction in weight over time, however, this was comparable between groups. There was no improvement observed in any of the echocardiographic parameters. In conclusion, cardiac function in obesity patients was not improved one-year after a novel tailor-made CR program (OPTICARE XL) as compared to usual CR.
Factorial Structure of the Emotional Beliefs Questionnaire: Testing Measurement Invariance and Competitive Models
Authors: Rogier Guyonne , Cavalli Roberta Gabriella , Maggiolo Chiara , Velotti Patrizia 
Published: March 2023

AbstractThe role of metacognitive beliefs towards positive and negative emotions has been stressed by several theoretical models. The Emotion Belief Questionnaire (EBQ) has been developed to assess these metacognitive beliefs. We administrated the Italian version of the EBQ, the Difficulties in Emotion Regulation Scale (DERS), the DERS-Positive and the short form of the Depression Anxiety Stress Scale (DASS-21) to a sample of Italian adults. (N = 516). Structural Equation Modelling testing the factorial structure of EBQ evidenced a good fit in the four-factor model compared to the three-factor model and model with two second order variables. The EBQ showed invariance across sex, and significant associations with validating variables. These results demonstrate the goodness of the four-factor structure for the EBQ and support its use for assessment of metacognition beliefs towards emotions.