bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of Prognostic Criteria for Severe Acute Pancreatitis in Patients With Early Nasogastric and Nasojejunal Feeding
Authors: Sivkov O. G. , Sivkov A. O. 
Published: August 2023

Objective: To evaluate the prognostic value of predictors of severe acute pancreatitis in patients with nasogastric (NG) and nasojejunal (NJ) feeding. Materials and methods: Our open-label randomized controlled study was carried out in the intensive care unit of Neftyanik Occupational Health Facility (Tyumen, Russian Federation) between November 2012 and October 2018 and included 64 patients who had predictors of severe acute pancreatitis (APACHE II score > 8, C-reactive protein [CRP] > 150 mg/L, SOFA score > 2) and could start early NG and NJ feeding. We evaluated the prognostic value of APACHE II, SOFA, BISAP, blood urea, and CRP in the general group and for different enteral feeding methods during the first 24 hours and in 48 hours. Data were statistically processed using the SPSS 26 software. Results: Only one prognostic model was statistically significant for the first 24 hours and included APACHE II (AUC = 0.705, 95 % CI 0.577-0.834, P = 0.005, cutoff threshold of 8.5, sensitivity of 0.394, and specificity of 0.935 for all patients). In 48 hours models of the following groups were statistically significant: that of all patients, which included APACHE II, CRP, and blood urea (AUC = 0.904, 95 % CI 0.826-0.983, P < .001, cutoff threshold of 0.65, sensitivity of 0.818, and specificity of 0.935), NJ feeding group with CRP (AUC = 0.775, 95% CI 0.611-0.94, P < .001, cutoff threshold of 209.0 mg/L, sensitivity of 0.529, and specificity of 1.0), and NG feeding group with APACHE II (AUC = 0.767, 95% CI 0.599-0.934, P < 0.001, cutoff threshold of 9, sensitivity of 0.625, and specificity of 0.882). Conclusions: Enteral feeding method does not affect the prognostic criteria for severe acute pancreatitis. 48 hours after admission is the best period period for severity prognosis, and the model with such independent predictors as APACHE II, blood CRP, and urea showed the best quality prognosis. If these predictors could not be used at once, we recommend APACHE II for NG feeding and blood CRP for NJ feeding.
Algorithm for Endovascular Treatment of Patients With Spinal Arteriovenous Malformations
Authors: Perfilyev A. M. , Rzaev J. A. 
Published: August 2023

Objective: To compare the endovascular treatment results in patients with spinal arteriovenous malformations (AVM) based on the proposed algorithm. Materials and methods: We retrospectively analyzed the endovascular treatment results in 72 patients with various types of spinal AVMs for 2014-2021. We formed 2 main groups of patients based on the developed indications for neurophysiological monitoring and provocative tests (NFM and PT): group 1 (n = 63) was treated according to the algorithm, and group 2 (n = 9) was treated before the algorithm was implemented. Group 1 was divided into subgroup 1.1 (n = 42) including patients with no indications for NFM and PT and subgroup 1.2 (n = 21) with patients indicated for NFM and PT. Subgroup 1.2 was further divided into subsubgroup 1.2A (n = 2) with patients indicated for NFM and PT yet to be informative due to severe neurological deficit and subsubgroup 1.2B (n = 19) with patients that had indications for and successfully underwent NFM and PT. We compared patients between groups 1 and 2, subsubgroup 1.2B and group 2 to evaluate the effectiveness of the algorithm (radical nature of the treatment, functional status assessment, complications). Results: Radical nature of spinal AVM treatment in group 1 was 79 % compared with 44 % in group 2 (P = 0.043). There was a significant improvement in motor function in group 1 compared with group 2 in each follow-up period (Р ≤ 0.007). Comparison of subsubgroup 1.2B and group 2 showed no significant differences (P = .05). The treatment led to complications in 5 patients (7 % of the total number of patients with spinal AVMs): 4 patients in group 2 and 1 patient in subsubgroup 1.2B. The effectiveness of the developed criteria was indirectly confirmed by difference in complications number between subsubgroup 1.2B and group 2 (P = 0.001). Conclusions: Group 1 showed better treatment results, significant clinical improvement, high radical nature of treatment, and a low percentage of complications compared with group 2. The proposed algorithm proved effective for main tasks of endovascular treatment of spinal AVMs.
Development of the Acellular Dermal Matrix and Experimental Substantiation of Its Use in the Anterior Abdominal Wall hernia Repair
Authors: Melkonian K. I. , Rusinova T. V. , Asyakina A. S. , Solop E. A. , Fomenco A. A. , Chuprynin G. P. 
Published: August 2023

Objective: To develop a biological implant that is an acellular dermal matrix (ADM), evaluate its use as a support material in tensionfree hernioplasty for ventral hernia, and compare it to that of the commercially available implant PermacolTM. Materials and methods: ADM was derived from the porcine dermis (Landrace breed) decellularized using detergents and enzymes. The quality of devitalization was assessed in vitro. We performed sublay hernioplasty in 4-month-old Landrace pigs using ADM (experimental group) and PermacolTM (control group). The specimens were explanted on day 120 of the experiment for histological and immunohistochemical examination. Results: All cellular elements were removed by the detergent-enzymatic treatment of the dermis; the native architecture of the dermis was slightly disrupted. The specimens of the commercially available chemically cross-linked biomaterial PermacolTM had better mechanical properties than ADM specimens; however, there were no significant differences in terms of cytotoxicity. The state of the tissues after the explantation (number of fibroblasts and endothelial cells) showed no differences in the result of using ADM and PermacolTM. In 120 days, the materials integrated into the tissues without the formation of adhesions or inflammation. Conclusions: Our findings show that ADM does not have cytotoxic properties, has adequate biomechanical parameters to effectively reinforce supporting soft tissues, does not cause an inflammatory response during implantation, and integrates fully into tissues. Our study demonstrates the effectiveness and utility of the developed ADM in surgical treatment of anterior abdominal wall defects.
Effectiveness of Autologous Platelet-Rich Plasma and Stromal Vascular Fraction in Autologous Skin Grafting
Authors: Derii E. K. , Zinovev E. V. , Kostyakov D. V. , Pyatakov S. N. , Manukovskiy V. A. 
Published: August 2023

Introduction: Despite the medical advances, burns remain a serious challenge and require new and promising treatment options, such as biomedical technologies with a high potential for burn wound treatment. However, high cost and complexity of biotechnologies limit their routine use, but autologous tissues, such as stromal vascular fraction (SVF) and autologous platelet-rich plasma (PRP), overcome these shortcomings. Objective: To demonstrate a successful case of using a combination of adipose-derived SVF and autologous PRP during autologous skin grafting in a severely burned patient. Material and methods: We present a successful case of 84-year-old Patient B. treated at Saint Petersburg I. I. Dzhanelidze Research Institute of Emergency Medicine in September-October 2022. He was diagnosed with a 11% (6%) / II-III degree flame burn of the head, neck, trunk, and upper extremities and first-degree inhalation injury. At the first stage, the general condition of the patient was stabilized, and he was prepared for surgery. At the second stage, on day 25 of treatment we performed skin grafting using split-thickness autografts with rare perforations and application of SVF and autologous PRP on a burn wound. We evaluated the treatment effectiveness using planimetry, cytology, and histology. Results: We observed complete engraftment of the autograft with no lysis or rejection during the first dressing change on day 3 after surgery and complete skin restoration on day 11. Cytologic findings over time showed an active decrease in inflammatory cells and an increase in regenerative cells, indicating successful wound healing. Histology demonstrated formation of normal stratified squamous epithelium with areas of hyperkeratosis and young granulation tissue in the superficial layers of the dermis on day 6. Conclusions: Our case demonstrated that the combination of SVF and autologous PRP facilitates split-thickness skin autograft engraftment.
Multidisciplinary Approach to the Management of Diabetic Foot Complications
Authors: Fedyushkin V. V. , Sukhoruchkin P. V. , Baryshev A. G. , Chibirov S. K. , Amirova R. K. , Shevchuk D. D. 
Published: August 2023

Background: According to the International Working Group on the Diabetic Foot (2015), 28 % of diabetic foot ulcers result in major amputations. Over 30 % of patients with diabetic foot undergo major amputations that result in death in 13.0 %-14.0 % of the cases. Clinical case: In our experience of treating a female patient with diabetic foot complications, we observed that such cases require a multidisciplinary approach to determine management strategies, as well as strict surgery staging. Early plastic and reconstructive surgery demonstrated its positive impact on postoperative wound closure. Conclusions: We managed the infection and achieved the complete closure of the major wound and primary intention healing through the multidisciplinary approach and strict adherence to surgical staging (debridement, revascularization, reconstruction). Thus, patient quality of life and rehabilitation potential significantly improved.
Active control of localized mode and transmission in topological phononic waveguides by non-Hermitian modulation
Authors: Ali Md. Shuzon , Hata Yusuke , Tsuruta Kenji 
Published: August 2023

Abstract
We demonstrate the switching behavioral differences between lossy and nearly lossless edge-mode propagation by non-Hermitian modulation based on the phononic band design of a C
3v symmetric, two-dimensional phononic crystal with a unit cell composed of three air-filled circular holes in polydimethylsiloxane. We numerically show that strong loss effects lead to the extinction of the localized modes. This mechanism is analogous to the bound-to-unbound transition in non-Hermitian quantum systems. This result suggests that large variations in non-Hermitian modulation can be used for the active control of edge-mode propagation along topological interfaces.
Strategy in increasing Consumer Loyalty
Authors: Ariffin Muchammad - 
Published: August 2023

The purpose of this study is to understand Strategy in increasing Consumer Loyalty. A Case Study of Indonesian Unilever Products. In particular, this study analyzes the relationshipbetween CSR, WOM and Company Reputation towards consumers' loyalty specially the products of Lifebuoy, Pepsodent, and Kecap Bango. Data was collected through a survey conducted among 110 respondents.Structural equation modeling was used to test the proposed hypothesis. The research model was tested using survey data analyzed by structural equation modelingof partial least squares. the implementation of CSR strategy shows that there is a significant influence of WOM and Company reputation on consumers' loyalty. On the other hand, CSR strategy has no significant influence the consumers' loyalty. Yet as CSR was carried out through the implementation of Word of mouth (WOM) and Company Reputation there is a significant correlation between CSR and the consumers' loyalty of Lifebuoy, Pepsodent, and Kecap Bango products. The use of data that is too small for each variable resulted in limited results. As well as the limited representation of all users and consumers of Unilever products in other cities. In addition, this study did not involve other companies that also use CSR strategies as a comparison.
Keywords :Corporate Social Responsibility (CSR), Word-of-mouth (WOM), Company Reputation, Consumers Loyalty, Social Company
Pengaruh Kualitas Pelayanan, Promosi, Dan Persepsi Harga Terhadap Kepuasan Pelanggan di Park Hotel Cawang
Authors: Rudy Nandito,Edvin Fairliantina  
Published: August 2023

The research conducted aims to analyze service quality, promotion, and price perceptions on customer satisfaction at Park Hotel Cawang. The type of data used is primary data in the form of respondents' opinions by distributing questionnaires. The population in this study were Park Hotel Cawang guests with a sample of 100 respondents. The data obtained will be analyzed using quantitative methods with multiple linear regression analysis. Based on the research that has been done, the results show that the variables of service quality, promotion, and price perception simultaneously and partially have a positive and significant effect on customer satisfaction.
Keywords: Service Quality, Promotion, Perceived Price, Customer Satisfaction
Penelitian yang dilakukan bertujuan untuk menganalisis kualitas pelayanan, promosi, dan persepsi harga pada kepuasan pelanggan di Park Hotel Cawang. Jenis data yang digunakan ialah data primer berupa pendapat responden dengan penyebaran kuesioner. Populasi dalam penelitian ini ialah tamu Park Hotel Cawang dengan sampel sebanyak 100 responden. Data yang didapatkan akan dianalisis menggunakan metode kuantitatif dengan analisis regresi linear berganda. Berdasarkan penelitian yang telah dilakukan, maka hasil menunjukkan bahwa variabel kualitas pelayanan, promosi, dan persepsi harga secara simultan maupun parsial berpengaruh positif dan signifikan terhadap kepuasan pelanggan.
Kata Kunci: Kualitas Pelayanan, Promosi, Persepsi Harga, Kepuasan Pelanggan
P M V U Auth: Physical Unclonable Function and Machine Learning based Zero Knowledge Internet of Vehicle Unlock and Authentication Framework
Authors: Sadhu Pintu Kumar , Abdelgawad Ahmed 
Published: August 2023

<p>Comfort has become a requirement in our modern world. This level of comfort, particularly in automobiles, can only be accomplished by outfitting the vehicle with additional electrical equipment. Some electronic equipment must communicate with one another, which necessitates the use of a data transmission. Nowadays, it is challenging to sell a new automobile that includes traditional keys. Now, a sophisticated remote locking system is used to lock and unlock autonomous vehicles (AV). A remote unlocking system consists of a transponder that wirelessly connects with the automobile transmitter to lock/unlock the automobile. Unfortunately, wireless communication methods of the internet of vehicle (IoV) face a number of threats. This study provides a safe solution for the automobile unlocking system that uses dynamically generated temporary keys to meet the future demands of smart cars driven by the Internet of Things. To maintain security, machine learning (ML) and physical unclonable function (PUF) are used to permit auto locking and unlocking capability in this work. The technique has exhibited 99.91\% accuracy, which proves the reliability of securing the automobile unlocking system. Moreover, the computation cost is 3.8 ms and communication overhead is 176 bytes for unlocking by the owner and 144 bytes when the car will be unlocked by other than the owner. Furthermore, both formal (Burrows–Abadi–Needham (BAN) logic) and informal security analysis of the proposed method are provided.</p>
Ramp Products in Real Time Markets for Low Carbon Resource Mix
Authors: Varghese Sushant , Giacomoni  , Retna Kumar Aravind , Wasti Shailesh , Webster Mort D. 
Published: August 2023

<p>With increased variable renewable generation and retirements of dispatchable thermal plants, net load variability and forecast error will increase. Many ISOs and RTOs have implemented or are considering implementing ramp products in their real-time markets to maintain both reliability and efficiency with the changing resource base. The design of any real-time market enhancement, however, must account for the fact that ISOs and RTOs use separate real-time engines for commitment, dispatch, and pricing. Depending on which engine is modified, there will be different impacts on reliability, system dynamics, system cost and prices. We present a rolling horizon simulation framework for the PJM Real-Time Market, consisting of a day-ahead model and real-time commitment, dispatch, and pricing engines that account for generator outages, net load variability and rolling short-term forecast error for a 2050 future capacity scenario. We compare the impacts across ramp product designs on system costs, reliability, prices, generation mix and generator revenues. We analyze the sensitivity of these results to the quantity of ramp product procured in the real-time commitment vs. dispatch and show that a balanced requirement added to both the commitment and dispatch engines provides the best performance across multiple metrics. </p>
Beta-cell Death and/or Stress Biomarkers in Diabetes Mellitus Type 1
Authors: Abd Ali Khudhair Hasan , Abd Ali Khudhair Hasan 
Published: August 2023

Diabetes Mellitus type 1 (T1D) occurs due to disturbance intolerance of the immune system and invasion of β-cells by auto-reactive immune T cells and inducing deterioration of β-cells activity and viability and a prolong therapy with external insulin. This study was aimed to detect the predictive power as well as the degree of correlation of defined glutamic acid decarboxylase autoantibody (GADA), protein tyrosine phosphatase type A2 (IA-2A) and total antioxidant capacity (TAC) biomarkers on β-cells stress and/or death in T1D individuals as well as their first degree relatives (FDRs). Three groups of T1D patients, FDRs and apparently diseases free subjects had been enrolled in this work and evaluated for their serum GADA, IA-2A, C-peptide and TAC. The results revealed positive GADA and IA-2A in 88.6% and 40%, respectively, of T1D patients. The frequency of normal level and mean titer of C-peptide were significantly low among T1D and their FDRs, also the frequency of normal level and mean titer of TAC was significantly low among T1D patients. However, no significant difference in C-peptide level was noticed between the GADA+ and GADA- subjects with no significant effect of TAC level on the concentration of C-peptide. Finally, the concentration of C-peptide was significantly lower in IA-2-A positive than IA-2-A negative individuals. In conclusion, GADA, IA-2A and C-peptide combination can suggest the most powerful and cost-effective diagnostic approach in patients with T1D and their FDRs. In addition, IA-2A in T1D patient’s serum can be predicted for β-cell death and/or stress, however, GADA and TAC was found of no effect on the C-peptide level.
Estimation of immunoglobulin ( IgG and IgM) in sera cutaneous leishmaniasis patients (L.donovani and L. infuntum) in Baghdad city
Authors: Rehman Alwan Haider , Suliman Erzaige Zainab 
Published: August 2023

Leishmaniasis are parasitic diseases caused by protozoan flagellates of the genus Leishmania, parasites infecting numerous mammal species, including human. Baghdad city regarded as endemic area for cutaneous leishmanisis,so an expermental study was done in Baghdad city , the sample taken from the patients cutaneous leishmaniasis attending dermatologic clinic in Baghdad Teaching Hospital and Al Yarmouk Teaching Hospital during the period from first of October 2017 to the first of February 2018.Ninety blood samples were collected from infected and suspected people with cutaneous leishmaniasis , which were confirmed by laboratory tests because they were all infected by amastigote form of cutaneous leishmaisis, as well as the data clarified there are a shared rate among people with cutaneous leishmaniasis and visceral leishmaniasis represented by L.donovani was( 10,11.1%) ,while L.infuntum was(40, 44.4%).
Development of a Conceptual Model to Understand Disease Burden in Patients With Systemic Lupus Erythematosus and Organ Damage
Authors: Broderick Lynne , Chen Wen-Hung , Levy Roger A. , Mitchell Foster April , Umanzor Figueroa Cindy , Gairy Kerry , Chauhan Deven 
Published: August 2023

Background: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that can lead to irreversible organ damage (OD). Data describing the patient burden of OD, as compared with SLE without OD, are limited. Objective: To develop a comprehensive conceptual model describing the burden experienced by patients living with SLE-associated OD. Methods: There were three phases to this qualitative study. First, a targeted literature review was conducted to inform a draft conceptual model. Second, key opinion leaders (KOLs) were interviewed to assess the draft conceptual model and help shape patient interview materials. Third, patients of different demographic backgrounds from across the United States were interviewed individually to gather their perspectives on living with SLE-associated OD. Data from concept elicitation interviews with KOLs and patients were coded and analyzed using NVivo software to identify the key concepts of the overall patient burden of SLE-associated OD. Findings from the KOL and patient interviews were used to finalize the conceptual model. Results: KOLs highlighted that SLE-associated OD carried a higher rate of mortality than SLE alone. Participants with SLE-associated OD (n = 40) experienced detrimental impacts across 4 areas of their lives: physical, cognitive, psychosocial functioning, and economic and work-related well-being. Physical impacts were described by all participants, often affecting their ability to perform everyday tasks. Many also described deterioration of cognitive functioning. Almost all participants experienced emotional impacts and challenges to their relationships and social lives resulting from living with SLE-associated OD. Additionally, SLE-associated OD imposed an economic burden including increased healthcare costs. SLE-associated OD had a more severe and debilitating impact on all aspects of the patient’s quality of life than SLE prior to OD development, including further limitations in activities of daily living after the development of OD. Discussion: Study findings guided the development of a comprehensive conceptual model that fully represents the patient experience of living with SLE-associated OD, highlighting the additional burden of OD when compared with SLE alone. Conclusions: The conceptual model will inform improvements in disease management, which may result in better patient outcomes and aid development of clinical outcome assessments of disease burden.
Integration of ESG Factors Into Financial Regulations In Brazil: An Overview
Authors: Moessa de Souza Luciane 
Published: August 2023

Objective: the integration of environmental, social and governance (ESG) factors into Brazilian financial regulations, including banking, capital markets, insurance and pensions.
Method: in first place, a full descriptive approach is adopted; then, the first main critical gaps and opportunities for improvement are raised, but without an exhaustive analytical approach.
Results: an overview of the current stage of integration of ESG factors into financial regulations in Brazil.
Conclusion: even if all Brazilian financial regulators have already addressed the topic, there are several opportunities for improvement, specially because the impact on market has been limited thus far.