bluuebunny/crossref_metadata_2025_split huggingface dataset:
Early Bronchodilator Reversibility Testing in a Morbidly Obese Population: Fluticasone/Salmeterol Efficacy Versus Salbutamol Bronchodilator
Authors: Ahmed Mona Ibrahim , Ahmed Randa Ibrahim , Osama Hasnaa , Khalifa Amira Karam , Alshehri Abdullah Ali , Batiha Gaber El-Saber , Negm Walaa A , Kamal Marwa 
Published: March 2023

Abstract
A positive response in reversibility testing is widely used to diagnose patients with airway limitations. However, despite its simple procedure, it doesn't accurately reflect the exact airway irreversibility. This study aimed to investigate the efficacy of early bronchodilation test using salbutamol and fluticasone/salmeterol combination in obese subjects.
The study included patients without a history of obstructive lung disease or bronchodilators. Sub-classification of patients based on body mass index (BMI) was carried out into normal (<24.9 kg/m2), overweight (25-29.9kg/m2), and obese (BMI≥30). Spirometry measurements were performed before and after salbutamol or fluticasone/salmeterol administration.
The study included 415 (49.9% male) patients with a mean age of 40.92±10.86 years. Obese subjects showed a high prevalence of restrictive patterns (23.4%), with non-significant lower spirometric values compared to normal and overweight subjects (p>0.05). The magnitude of bronchodilation, as identified by spirometry, following fluticasone/salmeterol was higher in all participants, with a significant increase in obese subjects with a p-value of 0.013, 0.002, and 0.035 for FEV1, FEV1% predicted and FEV1/FVC, respectively.
Fluticasone/salmeterol combination increases FEV1, FEV1% of predicted and FEV1/FVC ratio than the conventional test using salbutamol inhaler, and it can be a potential candidate for assessment of airway obstruction using reversibility test, especially among the obese population.
L3MBTL3 and active STAT3 collaboratively up-regulate SNAIL transcription to promote metastasis in breast cancer
Authors: Xiao Jianpeng , Wang Jie , Li Jialun , Xiao Jie , Liu Cuicui , Tan Libi , Tu Yanhong , Yang Ruifang , Pei Yujie , Wang Minghua , Wong Jiemin , Zhou Binhua , Li Jing , Feng Jing 
Published: March 2023

Abstract

Active STAT3 pathway promotes epithelial mesenchymal transition, migration, invasion and metastasis in cancer. STAT3 upregulates the transcription of epithelial mesenchymal transition key transcription factor SNAIL through DNA-binding independent way. However, the mechanism that how is STAT3 recruited to SNAIL promoter to upregulate transcription in DNA independent way is still unclear. In our study, we found a lysine methylated binding protein L3MBTL3 was positively associated with metastatic and poor prognosis in breast cancer. L3MBTL3 also promoted epithelial-mesenchymal transition, migration, invasion and metastasis in breast cancer. Mechanism analysis found L3MBTL3 interacted with active STAT3 and recruited active STAT3 on SNAIL promoter to up-regulated SNAIL transcription. The interaction between L3MBTL3 and active STAT3 was required for SNAIL transcription up-regulation, migration and invasion in breast cancer, while the methylated lysine binding activity of L3MBTL3 is not required for these functions. In conclusion, L3MBTL3 and active STAT3 collaboratively up-regulate SNAIL transcription to promote breast cancer metastasis.
Global economic impact of scuba dive tourism
Authors: Schuhbauer Anna , Favoretto Fabio , Wang Terrance , Aburto-Oropeza Octavio , Sala Enric , Millage Katherine , Cabral Reniel , Sumaila U. Rashid , Lucrezi Serena , Hsu Astrid , Tighsazzadeh Mohammad Nasir , Cruz Marisol Plascencia de la , Cisneros-Montemayor Andrés 
Published: March 2023

Abstract
Ecotourism presents an opportunity to provide equitable benefits to local communities; serve as a platform for environmental education; and can be leveraged to support conservation initiatives, shifting away from traditional mass tourism and other forms of unsustainable marine use. Marine ecotourism sectors, such as scuba diving, whale and shark watching are increasingly important for local economies but their aggregate benefits are often overlooked in global ocean economy discussions. Here, we present a first estimation of the global economic value of scuba diving, including 11,500 identified scuba dive operators across the world. Based on an online operator survey, we estimate global annual revenue (direct diving expenditure in 2019) at between 0.9–3.2 billion USD per year, and the broader economic impact (direct and indirect expenditure) at between 8.5 and 20.4 billion USD per year. Marine tourism is one of the largest sectors in the ocean economy, and with 8.9–13.6 million marine diving tourists worldwide supporting up to 124,000 jobs, the scuba diving sector could be at the forefront of transformative change for local and global ocean equity and sustainability.
Chatting with ChatGPT: Decoding the Mind of Chatbot Users and Unveiling the Intricate Connections between User Perception, Trust and Stereotype Perception on Self-Esteem and Psychological Well-being
Authors: Salah Mohammed , Alhalbusi Hussam , Ismail Maria Mohd , Abdelfattah Fadi 
Published: March 2023

Abstract
Artificial Intelligence (AI) technology has revolutionized how we interact with information and entertainment, with ChatGPT, a language model developed by OpenAI, one of its prominent applications. However, there is limited knowledge of the psychological impact of interacting with ChatGPT. This study investigates the relationships between trust in ChatGPT, user perception of ChatGPT, stereotype perception of ChatGPT, and two psychological outcomes: psychological well-being and self-esteem. The study hypothesizes that trust in ChatGPT, user perception of ChatGPT, and stereotype perception of ChatGPT have a positive direct relationship with self-esteem. Additionally, the study proposes that the relationship between trust in ChatGPT, user perception of ChatGPT, and psychological well-being is moderated by job anxiety. Using a survey design, data are collected from 732 participants and analyzed using SEM and SmartPLS analysis. The results indicated that stereotype perception of ChatGPT significantly predicts self-esteem, while user perception of ChatGPT and trust in ChatGPT have a positive direct relationship with self-esteem. The study also found that job anxiety moderates the relationship between user perception of ChatGPT and psychological well-being. The study provided important insights into the psychological effects of interacting with AI technology and highlighted the role of job anxiety in moderating these effects. These findings have implications for developing and using AI technology in various fields, such as mental health and human-robot interactions.
Rapid resistance profiling of SARS-CoV-2 protease inhibitors
Authors: Harris Reuben , Moghadasi Seyed , Biswas Rayhan , Harki Daniel 
Published: March 2023

Abstract
Resistance to nirmatrelvir (Paxlovid) has been shown by multiple groups and may already exist in clinical SARS-CoV-2 isolates. Here a panel of SARS-CoV-2 main protease (Mpro) variants and a robust cell-based assay are used to compare the resistance profiles of nirmatrelvir, ensitrelvir, and FB2001. The results reveal distinct resistance mechanisms (“fingerprints”) and indicate that these next-generation drugs have the potential to be effective against nirmatrelvir-resistant variants and vice versa.
WITHDRAWN: High-fat diet decreases anti-inflammatory activities due to the disturbance of hepatic lipid metabolism accompanied by intestinal microbiota and EGCG regulation in broilers
Authors: Dou Xiujing , Cui Ying , Wu Jiaqi , Zhang Man , Shan Anshan 
Published: March 2023

Abstract
Background:
Long or short-term high-fat diets often lead to adverse effects in the body, such as metabolic disorders, changes in the intestinal flora, and even cause inflammation. It also increases the risk of developing diseases like dyslipidemia, type 2 diabetes mellitus (T2DM), and fatty liver disease. The inflammatory links between a high-fat diet and diseases are currently unknown entirely. (-) - Epigallocatechin-3-gallate (EGCG), a major bioactive chemical substance extracted from green tea, is well-established in nutrient metabolism and lessens the occurrence. This study aims to demonstrate that high fat decreases disease tolerance, evaluate the alleviative effect of EGCG and explore the protective mechanism of EGCG from liver lipid metabolism and intestinal microflora.
Results:
We found that when broilers were fed a high-fat diet, they had symptoms such as liver hypertrophy, increased abdominal fat deposition, lipid metabolism disorder and changes in intestinal microbial structure. In addition, when broilers were fed with high fat for some time, lipopolysaccharide injection would expose more disadvantages of high fat, including increased oxidative damage and inflammatory damage. After administration of EGCG, liver hypertrophy, abdominal fat deposition, and liver lipid metabolism disorder were slowed down, and intestinal flora changes caused by a high-fat diet were regulated.
Conclusions:
The study showed that a high-fat diet decreases anti-inflammatory activities due to hepatic lipid metabolism and intestinal microbiota disturbances. EGCG alleviates the disorder of liver lipid metabolism and intestinal microbial structure in broilers, which is critical to maintaining lipid and microbial homeostasis during the pathogenesis of inflammation.
WITHDRAWN: Relative Importance Analysis Of Female Factors In Total Labor Force Participation
Authors: HUSNUOGLU Nadide , ODA Volkan 
Published: March 2023

Abstract

In this article, the effect of especially female factors on total labor force participation (LFP) is analyzed. The LFP rate shows the population willing to work. The high rate of this rate affects the economic growth and development and the welfare level of the country. Studies carried out to date have examined the factors affecting female LFP or total LFP. In this study, factors such as fertility, women's education, and dependency ratio on the total LFP are discussed more than the others. Again, unlike the literature, participation in the total workforce was analyzed with the Garson algorithm and artificial neural networks (ANN). As a result of the analyzes made, it has been obtained that the LFP rate follows a U-shaped path. It has been determined that the fertility rate (23.34%) has the maximum effect on LFP, and that ANN give very successful results in the estimation of the available data.
Interactome analysis of Crimean-Congo hemorrhagic fever virus glycoproteins reveals HAX1 as a host restriction factor against the virion packaging
Authors: Dai Shiyu , Li Qi , Feng Kuan , Min Yuan-Qin , Jiang Zhenyu , Ren Fuli , Fang Yaohui , Zhang Jingyuan , Zhu Qiong , Wang Manli , Wang Hualin , Deng Fei , Ning Yun-Jia 
Published: March 2023

Abstract
Crimean-Congo hemorrhagic fever virus (CCHFV) is a biosafety level-4 and World Health Organization-recognized priority pathogen requiring urgent Research & Development attention. The glycoproteins of CCHFV, Gn and Gc, are considered to play multiple roles in the viral life cycle by interactions with host cells; however, these interactions remain largely unclear to date. Here, we analyzed the cellular interactomes of CCHFV glycoproteins by affinity purification-quantitative mass spectrometry and identified 45 host proteins as high-confidence Gn/Gc interactors. These host molecules are involved in transmembrane transport, metabolism, oxidative stress, protein folding and glycosylation, etc., in line with the potential physiological actions of the viral glycoproteins. As a proof of principle, we detailedly elucidated the role of an identified cellular protein, HAX1, and therefore uncovered an interesting host antiviral strategy. HAX1 interacts with Gn by its C-terminus, while its N-terminal region leads to mitochondrial localization. By the strong interaction, HAX1 sequestrates Gn to mitochondria, thus depriving Gn of its normal Golgi localization that is indispensable for functional glycoprotein-mediated progeny virion packaging. Consistently, the notable inhibitory activity of HAX1 against viral packaging and hence propagation was further elucidated in the contexts of pseudotyped and authentic CCHFV infections by series of loss/gain-of-function assays in cellular and animal infection models. Together, the findings not only provide a systematic CCHFV Gn/Gc-host protein-protein interaction map, but also unravel a novel cellular antiviral mechanism, which may facilitate further studies on CCHFV biology and therapeutic approaches.
A Procedural Approach for Finding Kinetic Parameters of Polypropylene Gasification in Super Critical Water Using Genetic Algorithm
Authors: Gomaa Islam , Zanoni Marco , Butler James , Lotfi Samira 
Published: March 2023

Abstract
Plastic gasification under super critical conditions could yield a wide range of hydrocarbons depending on operating conditions. Phenomenological models describing such process involve multiple competing reaction routes. Different reaction mechanisms and kinetic parameters could be used to model the process. Introduced in this study, is a robust/procedural approach for finding the kinetic parameters. In this approach, genetic algorithm is utilized to find the rate constants at specific temperatures prior to finding the kinetic parameters (pre-exponential factor and activation energy). Rate constants are obtained sequentially, starting with the highest temperature and ending with the lowest temperature. Then, linear regression is used to calculate the kinetic parameters for all reactions. Values of kinetic parameters, obtained via linear regression, are used to set the limits for the genetic algorithm to find more accurate values of the kinetic parameters. The relative/normalized deviation, from the original data (main species concentration versus residence time), using this approach is 1.2%. The respective normalized deviation using linear regression was 2.7%.
Time to blood pressure control and predictors among patients receiving integrated treatment for hypertension and HIV based on an adapted WHO HEARTS implementation strategy at a large urban HIV clinic in Uganda
Authors: Amutuhaire Willington , Semitala Fred , Kimera Isaac , Namugenyi Christabellah , Mulindwa Frank , Ssenyonjo Rebecca , Katwesigye Rodgers , Mugabe Frank , Mutungi Gerald , Ssinabulya Isaac , Schwartz Jeremy , Katahoire Anne , Musoke Lewis , Yendewa George , Longenecker Chris , Muddu Martin 
Published: March 2023

Abstract
In this cohort study, we determined time to blood pressure (BP) control and its predictors among hypertensive PLHIV enrolled in integrated hypertension-HIV care based on the World Health Organization (WHO) HEARTS strategy at Mulago Immunosuppression Clinic in Uganda. From August 2019 to March 2020, we enrolled hypertensive PLHIV aged \(\ge\)18 years and initiated Amlodipine 5mg mono-therapy for BP (140–159)/(90–99) mmHg or Amlodipine 5mg/Valsartan 80mg duo-therapy for BP ≥ 160/90mmHg. Patients were followed with a treatment escalation plan until BP control, defined as BP < 140/90 mmHg. We used Cox proportional hazards models to identify predictors of time to BP control. Of 877 PLHIV enrolled (mean age 50.4 years, 62.1% female), 30% received mono-therapy and 70% received duo-therapy. In the monotherapy group, 66%, 88% and 96% attained BP control in the first, second and third months, respectively. For patients on duo-therapy, 56%, 83%, 88% and 90% achieved BP control in the first, second, third, and fourth months, respectively. In adjusted Cox proportional hazard analysis, higher systolic BP (aHR 0.995, 95% CI 0.989–0.999) and baseline ART tenofovir/lamivudine/efavirenz (aHR 0.764, 95% CI 0.637–0.917) were associated with longer time to BP control, while being on ART for > 10 years was associated with a shorter time to BP control (aHR 1.456, 95% CI 1.126–1.883). The WHO HEARTS strategy was effective at achieving timely BP control among PLHIV. Additionally, monotherapy anti-hypertensive treatment for stage I hypertension is a viable option to achieve BP control and limit pill burden in resource limited HIV care settings.
Dapagliflozin Attenuates NLRP3/Caspase-1 Signaling Pathway-Mediated Pyroptosis of Vascular Smooth Muscle Cells by Down-regulating CTSB
Authors: Li Hui , Zhao Quanwei , Liu Danan , Zhou Bo , Gong Caiwei , Zhao Guangjian 
Published: March 2023

Abstract
Background
•Atherosclerosis is a chronic inflammatory disease.Pyroptosis triggers and amplifies the inflammatory response and plays an important role in AS.Cathepsin B (CTSB) canpromote AS and activate NLRP3 to mediate pyroptosis.Dapagliflozin (DAPA) can inhibit cell pyroptosis to improve AS.This study aimed to explore the effect of DAPA on oxidized low-density lipoprotein (ox-LDL)-induced pyroptosis of vascular smooth muscle cells (VSMCs)and its underlying mechanism.
Methods
• VSMCs were transfected with cathepsin B (CTSB)-overexpressing and -silencing lentiviral vectors.Then,VSMCs were treated with different concentrations of ox-LDL ( 0,50,100,150µg/ml ), Hoechst33342/PI double staining and LDH release assay were used to detect cell pyroptosis.After VSMCs were treated with different concentrations of DAPA ( 0.1µM, 1.0µM, 5.0µM, 10µM, 25µM, 50µM ), the proliferation activity of VSMCs was detected by CCK8 method.On the basis of ox-LDL-induced VSMCs pyroptosis, DAPA intervention, overexpression and silencing of CTSB were used to observe the effects of DAPA and CTSB on Ox-LDL-mediated VSMCs pyroptosis.
Results
• 1) VSMCs stably transfected with CTSB-overexpressing and -silencing lentiviruses were obtained, 150 µg/mL was the optimal concentration of ox-LDL for inducing pyroptosis of VSMCs, and 0.1 µM was the optimal concentration of DAPA for ameliorating pyroptosis of VSMCs. 2) Ox-LDL-induced pyroptosis of VSMCs was worsened by overexpression of CTSB but suppressed by silencing of CTSB. 3) DAPA attenuated ox-LDL-induced pyroptosis of VSMCs through down-regulating CTSB and NLRP3. 4) Overexpression of CTSB based on DAPA intervention aggravated ox-LDL-induced pyroptosis of VSMCs.
Conclusion
• DAPA attenuates NLRP3/caspase-1 pathway-mediated pyroptosis of VSMCs through down-regulating CTSB.
BMI (35-39.9 kg/m2) is associated with a significantly lower risk of cardiovascular morbidity compared with a normal BMI
Authors: Hong Mengjie , Chang Yafei , Jiang Peipei , Sun Ling , Ma Yitong , Ma Xiang , Yuan Qinghua 
Published: March 2023

Abstract
Objective
Obesity has been considered as a major risk factor for coronary heart disease (CHD), but the association between CHD and the degree of obesity is unclear. The objective of this study is to explore these relationships.
Methods
A total of 8299 patients from Xinjiang, China were enrolled in this study. BMI was categorized as normal (18.5–24.9 kg/m2), overweight (25.0–29.9 kg/m2), obesity class I (30.0–34.9 kg/m2), class II (35.0–39.9 kg/m2) and class III (≥ 40 kg/m2). We used logistic regression models to investigate differences in CHD risk between BMI categories and performed subgroup analysis in post-menopausal women.
Results
In this study, 62.1% of patients were overweight or obese, and only 37.9% had normal BMI. Logistic regression analysis showed that age [OR = 1.04, 95%CI (1.04–1.05), P < 0.01], and diabetes Yes vs. No [OR = 2.27, 95%CI (1.88–2.74), P < 0.01] might be independent predictors of CHD. Alcohol consumption Yes vs. No [OR = 0.70, 95%CI (0.56–0.88), P < 0.01] may decrease the risk of CHD. Lower risk was found in the obesity class II (BMI 35.0–39.9 kg/m2) group [OR = 0.62, 95%CI (0.41–0.93), P = 0.02] compare to people with normal weight. Postmenopausal women with a BMI of 35.0–39.9 kg/m2 also had a lower risk for CHD compared to women with normal weight.
Conclusion
We found that individuals with lower BMI might not necessarily have a lower risk for CHD, obese individuals with BMI between 35-39.9 kg/m2 might have a lower CHD risk compared to individuals who are of normal weight. Obesity evaluation and CHD risk prediction should require a more comprehensive assessment.
Eyes in the sky on Tigray - Monitoring the impact of armed conflict on cultivated land using satellite imagery in Ethiopia
Authors: Weldegebriel Liya , Negash Emnet , Nyssen Jan , Lobell David 
Published: March 2023

Abstract
The war in Tigray, Ethiopia has displaced millions of people and created a humanitarian crisis. However, the impacts of the conflict on cultivated land area and local food production remains poorly quantified, hindering aid efforts. We used Sentinel-2 satellite imagery and developed multiple cultivation detection criteria based on Normalized Difference Vegetation Index time series validated using field observations from 2021 and 2022. Significant net losses of well cultivated land in highland croplands (elevation ≥ 1200 m) were observed between 2019/20 (pre-war) and 2021 (in-war), with greater losses in areas with higher density of conflict incidents. Sub-regions with high estimated loss of well cultivated land also exhibited high numbers of internally displaced people (IDP), consistent with a causal effect of the conflict on land abandonment. Our study estimated that the kilocalories lost due to abandonment of croplands (excluding Western Tigray zone) could have supported about 1.2 times the recorded IDPs in the region.
Load Bearing Properties of Environment Friendly Green Pea Pod Cellulose Toughened Sunn Hemp Polyester Composite
Authors: Alshahrani Hassan , VR Arun Prakash 
Published: March 2023

Abstract
This study focuses to develop an environmental friendly polymer composite for various technological applications. The primary objective of this study was to determine the load bearing effect of green pea pod cellulose addition into the polyester resin along with sunn hemp fiber. The microcrystalline cellulose was developed from the waste green pea pods and the composites were fabricated using hand layup method. The results revealed that adding 2 and 35 vol.% of cellulose and fibre increased the tensile strength, tensile modulus, flexural strength, hardness, Izod impact, and ILSS for PSC3 composite by 136 MPa, 3.85 GPa, 190 MPa, 5.72 GPa, 83 Shore-D, 4.77 J, and 27.4 MPa respectively. Moreover, the composite PSC3 gave maximum fatigue life counts of 30862, 28041 and 24384 for 30%, 60%, and 90% of UTS. The composite designated as PSC3 which has cellulose contains of 2.0 vol.% was found to significantly increase the storage modulus. Similarly, the drop load impact testing demonstrated that composite PSC3 shows the highest energy absorption up to 12.2 J. SEM fractograph revealed improvement in toughness as well as enhanced fiber-matrix interface. These load bearing properties improved eco-friendly composites could preferable in industrial, automotive, defence, aero structure and domestic architectural applications with high environmental safety concern.
Blockchain machine learning based personal health record data analysis with smart decentralization and security enhancement
Authors: Shah Harshal , Rai Keerti , Singh Deepti , Gupta Sachin , B.R Sampangirama Reddy , TRIPATHI RAMESH CHANDRA 
Published: March 2023

Abstract
An essential component of a patient's follow-up is a medical record. It includes opinions, prescriptions, analyses, and all patient data of healthcare professionals. Process of sharing as well as managing this file involves a number of players, including patient, doctor, and pharmacist. Electronic medical record (EMR) can be accessed by any authorized individual from any location, and data are shared among various health service providers. Using blockchain machine learning techniques, this study proposes a novel method for personal health records (PHR) -based data analysis and network security enhancement. Variational Boltzmann spatio encoder neural networks were utilized for the data analysis of personal health records. The decentralized blockchain architecture enhances network security. Based on network security and data analysis, the experimental analysis is conducted in terms of random accuracy 81%, specificity55%, latency 62%, QoS 52%, and computational cost 41%.