bluuebunny/crossref_metadata_2025_split huggingface dataset:
The mindset of birth predicts birth outcomes: Evidence from a prospective longitudinal study
Authors: Hoffmann Lisa , Hilger Norbert , Banse Rainer 
Published: March 2023

AbstractIn this paper we explore whether mental representations about birth (birth‐related mindsets) assessed during pregnancy can predict labour and birth in the sense that the perception of birth as a natural (rather than a medical) event increases the probability of a low‐intervention birth. Birth, in turn, might affect short‐term and long‐term psychological well‐being. These assumptions were tested in a longitudinal study (N = 311), spanning the first half of pregnancy and up to 6 months after birth. The results of a single indicator model displayed a sequential process: women who held a more natural mindset prenatally were more likely to have low‐intervention births, which resulted in a more positive evaluation of the birth experience, which in turn predicted well‐being in the first weeks after birth (measured with ecological momentary assessment), and subsequently postpartum depression and post‐traumatic stress symptoms 8 weeks after birth as well as mother‐infant bonding 6 months after birth. The study demonstrates the relevance of psychological factors for childbirth. The construct of a birth‐related mindset could contribute to a better understanding of childbirth and help to make women's birth experiences safer and more satisfying and to improve the transition to motherhood.
Analysis of spatio‐temporal propagation of occipito‐frontal spikes in childhood epilepsies by 3D sequential voltage mapping and dipole localization
Authors: Balaram Neetha , Jose James , Gafoor Abdul V. , Balachandran Smita , James Joe , Ramachandran Aparna , H Ramesh Shivakumar , Prabhakaran Anjana 
Published: March 2023

AbstractObjectiveWe sought to study the spatio‐temporal propagation of occipito‐frontal spikes in childhood epilepsies by voltage mapping and dipole localization and identify types of occipito‐frontal spikes based on onset, propagation, and stability of their dipoles.MethodsSleep EEG data of children, aged 1–14 years, with a minimum 1 h of recording from June 2018 to June 2021, were analyzed to identify occipito‐frontal spikes. In total, 150 successive occipito‐frontal spikes were manually selected from each EEG and using a source localization software were averaged using automated pattern matching with a threshold of 80%, and sequential 3D voltage maps of averaged spike were analyzed. Stability quotient (SQ) was calculated as the total number of averages/150. Stable dipole was defined as SQ ≥ .8. Dipole analysis was performed with principal component analysis using an age‐appropriate template head model.ResultsTen children with occipito‐frontal spikes were identified; five with self‐limited epilepsy with autonomic seizures (SeLEAS) and five with non‐SeLEAS epilepsies. Three types of occipito‐frontal spikes were identified: (1) narrow occipito‐frontal spikes with stable dipoles seen in all five children with SeLEAS which were “apparently” synchronous and bilateral clone‐like with an occipito‐frontal interval of 10–30 ms and a homogeneous propagation pattern from a unilateral medial parieto‐occipital region to an ipsilateral mesial frontal region; (2) wide occipito‐frontal spikes with stable dipoles seen in one child with non‐SeLEAS and developmental and/or epileptic encephalopathy with spike–wave activation in sleep (D/EE‐SWAS) with an occipito‐frontal interval of 45 ms, caused by focal spike propagation from a deeper temporal focus to ipsilateral peri‐rolandic cortex; and (3) wide occipito‐frontal spikes with unstable dipoles seen in four children with non‐SeLEAS lesional epilepsies with an occipito‐frontal latency of >50 ms and heterogeneous propagation patterns with poor intra‐individual dipole stability.SignificanceWe successfully identified different types of occipito‐frontal spikes in childhood epilepsies. Although the term “occipito‐frontal” is used to describe these spikes on the 10–20 EEG system, true propagation from occipital to frontal regions is not necessary. It is possible to differentiate idiopathic from symptomatic cases by analyzing the stability quotient and the occipito‐frontal interval of occipito‐frontal spikes.
Reduction of aflatoxins during brewing of a Malawian maize‐based non‐alcoholic beverage, thobwa
Authors: Namaumbo Sydney , Monjerezi Maurice , Gama Aggrey , Mlangeni Angstone Thembachako , Chiutsi‐Phiri Gabriella , Matumba Limbikani 
Published: March 2023

AbstractThis study reports onthe effect of various production steps on levels of aflatoxins during preparation of thobwa, a traditional maize‐based fermented non‐alcoholic beverage, brewed across Malawi. The effect of boiling, fermentation and their interaction on the level of aflatoxins, the trends of aflatoxin reduction during brewing, and the distribution of aflatoxins between the solid and liquid phases of the beverage were studied using VICAM AflaTest immunoaffinity fluorometric assay. Fermenting and boiling thobwa pre‐mix‐, with initial aflatoxin content of 45–183 μg/kg, resulted in aflatoxin reduction of 47% (13–61 μg/kg) on average. Fermentation and boiling contributed about 20 and 33% aflatoxin reduction, respectively, but without interactive effect between the two factors. Fermenting the thobwa for 24 h led to further reduction of aflatoxins to about 37% of the initial content, and remainedconstant for up to 8 days. Thobwa is a popular beverage in Malawi which is consumed in large quantities by all gender categories including infants, therefore the presence of aflatoxins may constitute a significant health risk factor. This study highlights the need to use raw materials with low levels of aflatoxins for production of maize‐based non‐alcoholic beverages to ensure consumer safety.
An efficient DNAzyme for the fluorescence detection of Vibrio cholerae
Authors: Miao Qingzhen , Ding Wen , Bao Xiuli , Wang Siyuan , Lin Qianru , Xu Yingying , Lu Jing , Lyu Mingsheng , Wang Shujun 
Published: March 2023

AbstractVibrio cholerae (Vc) causes cholera disease. Vc contamination is widely found in water and aquatic products, and therefore is a serious food safety concern, especially for the seafood industry. In this paper, we attempted the rapid detection of V. cholerae. Nine rounds of in vitro selection using an unmodified DNA library were successfully performed to find specific DNAzymes of Vc. Their activity was evaluated based on a fluorescence assay and gel electrophoresis. Finally, a DNAzyme (named DVc1) with good activity and specificity with a detection limit of 7.2 × 103 CFU/mL of Vc was selected. A simple biosensor was constructed by immobilizing DVc1 and its substrate in shallow circular wells of a 96‐well plate using pullulan polysaccharide and trehalose. When the crude extracellular mixture of Vc was added to the detection wells, the fluorescent signal was observed within 20 min. The sensor effectively detected Vc in aquatic products indicating its simplicity and efficiency. This sensitive DNAzyme sensor can be a rapid onsite Vc detection tool.
Effects of high‐protein milk powder, linseed paste, and grape molasses levels on physiochemical, rheological, and sensory attributes of linseed spread
Authors: Rahbari Siamak , Tavakolipour Hamid , Kalbasi‐Ashtari Ahmad 
Published: March 2023

AbstractSeparate levels of roasted linseed paste (RLP) (15, 22.5, and 30 g), Persian grape molasses (PGM) (40, 50, and 60 g), and high‐protein milk powder (HPMP) (3.75, 6.5, and 9.25 g) were ground and mixed in a ball mill (3 h at 45°C) to make samples of linseed spread (LS). After applying response surface methodology and central composite design, the optimized LS was obtained with 22.5 g RLP, 50 g PGM, 6.5 g HPMP, fine particle sizes (<30 μm), and 92% of the highest acceptable sensory scores (ASS). The mathematical model of ASS had good fitness (R2 > 95%) with the ingredient's levels of LS samples. While the PV, aw, and acidity of optimized LS did not change even after 90‐day storage at 4°C, it showed viscoelastic properties and very low stickiness (0.2–0.4 mJ). Additionally, the hardness, adhesiveness, cohesiveness, springiness, gumminess, and chewiness of optimized LS, respectively, decreased by 50, 25, 3, 8, 55, and 63% when its temperature increased from 4 to 25°C.
Fuzzy evaluation on the integrated benefit of regulated deficit irrigation for pear‐jujube tree based on information entropy
Authors: Guo Weihua , Gao Yun 
Published: March 2023

AbstractBased on the experimental data of regulated deficit irrigation at different growth stages on field pear‐jujube tree (Zizyphus jujube Mill.) during 2005–2007 in Northwest China, the regulated deficit irrigation integrated benefits (RDIIB) with different water deficit treatments at different growth stages were evaluated and classified using a model. The results in 2005–2006 showed that the RDIIB under single‐stage water deficit at fruit maturity stage were better than the other treatments, and the best RDIIB were gained under moderate (IVSD) or severe deficit (IVMD) at fruit maturity stage. The results in 2006–2007 also indicated that the four double‐stage water deficit schemes have the better RDIIB, and the best scheme was severe water deficit at bud burst to leafing stage plus moderate water deficit at fruit maturity stage. The RDIIB evaluation model based on information entropy method provided the reliable technical guidance for the optimal RDI scheme of pear‐jujube tree.
Prophylactic versus reactive feeding approach in patients undergoing adjuvant radiation therapy for oral cavity squamous cell carcinoma: A propensity score matched‐pair analysis
Authors: Ghosh Laskar Sarbani , Sinha Shwetabh , Gupta Meetakshi , Karmakar Shreyasee , Nivedha J. Meenakshi , Kannan Sadhana , Budrukkar Ashwini , Swain Monali , Kumar Anuj , Gupta Tejpal , Murthy Vedang , Chaukar Devendra , Pai Prathamesh , Chaturvedi Pankaj , Pantvaidya Gouri , Nair Deepa , Nair Sudhir , Thiagarajan Shivakumar , Deshmukh Anuja , Noronha Vanita , Patil Vijay , Joshi Amit , Prabhash Kumar , Agarwal Jai Prakash 
Published: March 2023

AbstractBackgroundTo assess the efficacy of prophylactic versus reactive feeding strategy in oral cavity squamous cell carcinoma (OCSCC) patients receiving adjuvant radiation therapy (RT).MethodsThis was a post hoc analysis of patients of OCSCC enrolled in a randomized trial comparing three adjuvant strategies. In this trial, till 2010, a prophylactic feeding approach was followed for all patients. Since January 2011, a reactive feeding approach was followed.ResultsTwo hundred and sixty‐eight in each cohort (total n = 526) were eligible for analysis after propensity score matching. At 6 weeks post‐RT completion, the median weight loss in the prophylactic versus reactive cohort was 5 versus 3 kg, p = 0.002. At all other time points until 1 year, the median weight loss was lesser in reactive than in the prophylactic cohort.ConclusionsA reactive feeding tube approach should be preferred for OCSCC receiving adjuvant RT.
DNA methylation testing for endometrial cancer detection in urine, cervicovaginal self‐samples and cervical scrapes
Authors: Wever Birgit M. M. , van den Helder Rianne , van Splunter Annina P. , van Gent Mignon D. J. M. , Kasius Jenneke C. , Trum Johannes W. , Verhoeve Harold R. , van Baal Wilhelmina M. , Hulbert Alicia , Verhoef Lisanne , Heideman Daniëlle A. M. , Lissenberg‐Witte Birgit I. , van Trommel Nienke E. , Steenbergen Renske D. M. , Bleeker Maaike C. G. 
Published: March 2023

AbstractEndometrial cancer incidence is rising and current diagnostics often require invasive biopsy procedures. DNA methylation marker analysis of minimally‐ and non‐invasive sample types could provide an easy‐to‐apply and patient‐friendly alternative to determine cancer risk. Here, we compared the performance of DNA methylation markers to detect endometrial cancer in urine, cervicovaginal self‐samples and clinician‐taken cervical scrapes. Paired samples were collected from 103 patients diagnosed with stage I to IV endometrial cancer. Urine and self‐samples were collected at home. All samples were tested for nine DNA methylation markers using quantitative methylation‐specific PCR. Methylation levels measured in endometrial cancer patients were compared to unpaired samples of 317 healthy controls. Diagnostic performances were evaluated by univariable and multivariable logistic regression analysis, followed by leave‐one‐out cross‐validation. Each methylation marker showed significantly higher methylation levels in all sample types of endometrial cancer patients compared to healthy controls (P < .01). Optimal three‐marker combinations demonstrated excellent diagnostic performances with area under the receiver operating curve values of 0.95 (95% CI: 0.92‐0.98), 0.94 (0.90‐0.97) and 0.97 (0.96‐0.99), for endometrial cancer detection in urine, self‐samples and scrapes, respectively. Sensitivities ranged from 89% to 93% at specificities of 90% to 92%. Virtually equal performances were obtained after cross‐validation and excellent diagnostic performances were maintained for stage I endometrial cancer detection. Our study shows the value of methylation analysis in patient‐friendly sample types for endometrial cancer detection of all stages. This approach has great potential to screen patient populations at risk for endometrial cancer.
Different treatment efficacies and T790M acquisition of EGFR‐TKIs on NSCLC patients with variable Del‐19 subtypes of EGFR
Authors: Wu Shang‐Gin , Gow Chien‐Hung , Chen Yi‐Ling , Liu Yi‐Nan , Tsai Meng‐Feng , Shih Jin‐Yuan 
Published: March 2023

AbstractEGFR exon 19 deletion (Del‐19) comprises multiple advanced NSCLC subtypes. EGFR‐tyrosine kinase inhibitor (TKI) efficacy and T790M acquisition in various Del‐19 subtypes is unknown. We prospectively collected tissue samples from patients harboring NSCLC with Del‐19 between 2006 and 2020. We evaluated EGFR‐TKI treatment effectiveness among the different Del‐19 subtypes. We collected 1391 NSCLC samples from 892 patients with Del‐19, and the most common subtype was del E746‐A750 (67.5%). 741 patients had taken first‐ or second‐generation EGFR‐TKIs. There were no significant differences in response rates between patients with different Del‐19 subtypes (P = .630). Patients with indel E746 had the longest median PFS (14.6 months), but those with non‐LRE deletions had the shortest PFS (8.9 months; P = .002). For OS analysis, patients with indel E746 also had the longest OS (34.1 months), but those with non‐LRE deletions had the shortest OS (21.1 months; P = .046). Patients with different Del‐19 subtypes showed no significant differences in the T790M acquisition rates (P = .443). Among the 151 patients with acquired T790M who received third‐generation EGFR‐TKIs, the Del‐19 subtype was not associated with different RR and PFS. In vitro cellular viability and activation of the EGFR pathway analysis were consistent with the clinical findings. In conclusion, compared with del E746‐A750, indel E746 was associated with longer PFS and OS, but the non‐LRE subtype was correlated with shorter survival prognosis. There were no significant differences in the acquired T790M rate and treatment effectiveness of subsequent third‐generation EGFR‐TKIs between various Del‐19 subgroups.
The impact of the COVID‐19 pandemic on mental health, associated factors and coping strategies in people living with HIV: a scoping review
Authors: Hong Chenglin , Queiroz Artur , Hoskin Jordan 
Published: March 2023

AbstractIntroductionThe COVID‐19 pandemic and associated measures implemented by authorities have created additional stressors and increased the risk of psychological illnesses among people living with HIV (PLWH). Yet, there is no collective evidence on the mental health status of this population during the global pandemic and associated factors. This scoping review aimed to synthesize the evidence in the current literature related to the mental health outcomes and challenges faced by PLWH during the COVID‐19 pandemic, identify the associated factors with psychological distress and summarize various coping strategies to ease these psychological distresses used by this population.MethodsWe conducted a scoping review following the PRISMA‐ScR guideline and a literature search in four electronic databases in August 2022. Three reviewers independently screened all the search records and extracted the data from studies that met the inclusion criteria. Factors associated with worsened mental health outcomes were synthesized according to the socio‐ecological framework.ResultsAmong 1100 research records, 45 articles met the eligibility criteria and were included in the final review and data extraction, most of which were quantitative analyses. PLWH reported high rates of mental health problems during the pandemic. Multi‐level factors were associated with increased psychological distress, including substance use, antiretroviral adherence, social support, financial hardship and economic vulnerability during the pandemic. PLWH used social media as a coping strategy to foster social support to deal with growing mental distress. Increased mental health illnesses were associated with increased substance use, it was also found associated with suboptimal medication adherence and antiretroviral therapy (ART) care engagement.DiscussionPLWH experienced high rates of mental health illnesses, such as depression during the global COVID‐19 pandemic. There is an urgent need to provide comprehensive HIV treatment and mental health services as the pandemic continues to evolve.ConclusionsThe review summarized how the mental health of PLWH was affected during the COVID‐19 pandemic. Future work in the implementation of effective interventions to promote mental health in this population is needed, not only to ensure their quality of life but also to help them maintain ART adherence and healthcare during more unprecedented times.
Serial Cardiac MRI for Quantification of the Dynamics of Anthracycline‐Induced Subclinical Myocardial Injury
Authors: Zheng Yue , Liu Hui , Zhao Li , Guan Shu , Huo Huaibi , Li Han , Guo Jie , Peng Xin , Hao Yuetong , Jin Shiqi , Hou Yang , Dai Xu , Liu Ting , Zhang Xinfeng 
Published: March 2023

BackgroundAnthracyclines are known to be associated with chemotherapy‐induced cardiotoxicity. Limited data focus on dynamic myocardial injury during the course of chemotherapy in patients with breast cancer.PurposeTo investigate the variation of tissue characterization and myocardial deformation derived by cardiac MRI during anthracycline chemotherapy.Study TypeProspective.PopulationFifty‐eight female breast cancer patients (mean age: 52.82 ± 2.61 years) were enrolled.Field Strength/SequenceA 3.0‐T, cardiac MRI including cine balanced steady‐state free precession, a modified Looker‐Locker inversion recovery (MOLLI), and a fast spin echo (FSE) T2‐weighted sequences were performed.AssessmentCardiac MRI was performed baseline and after two, four, and six cycles of chemotherapy. Assessment of global longitudinal strain (GLS), global circumstance strain (GCS), global radial strain (GRS), and strain rate (GLS‐s, GCS‐s, GRS‐s) and T1, T2 and T2* were accomplished by CVI42. The anthracycline dose and risk factors were also collected before each cardiac MRI.Statistical TestsAnalysis of variance (ANOVA) for repeated measures was used to compare the changes in LVEF cardiac function, strain and T1/T2/T2* parameters over time. Pearson correlation analyses were performed to estimate the potential associations between differences in myocardial characteristics (∆) and the chemotherapy cycle. A P value <0.05 was considered statistically significant.ResultsLVEF was not significantly different from pretreatment MRI regarding each cycle of chemotherapy (P = 0.54). Compared with baseline, patients had significantly lower GLS (−15.85% ± 0.83%, −14.50% ± 0.88%, −12.34% ± 1.01% vs. –18.82% ± 0.92%) and GLS‐s (−0.71% ± 0.07%, −0.65% ± 0.05%, −0.64% ± 0.04% vs. –0.95 ± 0.06%) and increased T2 values (57.21 ± 4.27 msec, 58.60 ± 3.93 msec, 58.10 ± 3.17 msec vs. 43.88 ± 3.28 msec) at two, four and six cycles of chemotherapy treatment. ∆GLS and ∆GLS‐s were significantly associated with the chemotherapy cycle (correlation coefficients for GLS = 0.75, GLS‐s = 0.75).Data ConclusionCardiac MRI can precisely detect the dynamic changes of anthracycline‐induced subclinical myocardial injury that is represented as a gradually decrease in GLS and GLS‐s. These parameters may provide new insight for monitoring risk and therapy in patients with breast cancer.Evidence Level2.Technical EfficacyStage 1.
Inversion of one‐dimensional parameters of horizontal multi‐layer soil model based on dynamic state electromagnetic field theory and ant colony optimization algorithm
Authors: Li Zhong‐Xin , Wang Ke‐Chao 
Published: March 2023

AbstractBuilding a reliable soil model is a prerequisite for accurately calculating the ground potential distribution of the grounding grid. Research shows that the soil electrical parameters are frequency‐dependent, so frequency domain inversion of soil parameters should consider the soil inhomogeneity and the frequency characteristic of parameters. A method for retrieving parameters of horizontal multilayer soil model is proposed. The theoretical formula of apparent complex resistivity with considering dynamic state electromagnetic field theory is derived from Green's function. Discrete dynamic state complex image method is introduced to solve the infinite integral in Green's function. Ant colony optimization algorithm is applied to optimize the inversion process of soil parameters. In the first stage, applicability of this method is confirmed by interpreting field data under DC field. DC parameters including DC resistivity, thickness and number of layer are determined. The performance of different optimization algorithms in terms of computational efficiency is compared at this stage. In the second stage, soil resistivity and relative dielectric constant are retrieved by inverting frequency domain experimental data. Different representations based on quasi‐static electromagnetic field and dynamic state electromagnetic field theories are taken into account. The frequency characteristic of soil parameters is concluded by discussing the inversion results. In the study of parameter inversion of horizontal multi‐layer soil model, our method has shown strong performance in computational efficiency and accuracy of inversion results.
Cross‐cultural experiences and self‐protective leadership: A multi‐country comparison of managerial perception
Authors: Kroumova Maya , Mittal Rakesh 
Published: March 2023

AbstractIn this study, we examine the effect of cross‐cultural experiences on perceptions of the effectiveness of self‐protective leadership (SPL). We use survey data from 15 non‐western countries collected in the second wave of the GLOBE leadership project to analyze the relationship between the global experiences of non‐western managers and the leadership schemas they hold. We examined three types of global experience – working in a multinational corporation, being trained in western management practices (WMP), and living abroad – and the leadership schema of self‐protective leadership (SPL). These results show that prior work experience in a multinational company and receiving training in WMP are associated with more negative perceptions of SPL, whereas having lived abroad has a more complex relationship with SPL. These results provide empirical evidence for the link between global experiences and cognitive schemas about leadership. Non‐western managers with international work experience and training hold SPL schemas that are significantly different from the SPL schemas of their peers with no such experience. Further, consistent with Implicit Leadership Theory (ILT) and recent research that links leadership effectiveness to expectations about behaviors associated with gender stereotypes, we find that SPL, a leadership style that encompasses behaviors that are traditionally associated with a male stereotype (conflict inducement, procedure orientation, status enhancement), is viewed more negatively by female managers compared to their male counterparts. Practical implications of our findings are provided.