bluuebunny/crossref_metadata_2025_split huggingface dataset:
YEAR-WISE TRENDS AND ANALYSIS OF MATERNAL MORTALITY IN AN OBSTETRIC UNIT OF A TERTIARY CARE HOSPITAL
Authors: Akhtar Zubaida , Khan Javeria , Qadir Maimoona , Nazaneen Saira , Samad Ambareen 
Published: January 2025

Objective: to review the trends and causes of maternal mortality in a tertiary care hospital in Peshawar.
Study design: A retrospective observational study.
Place of study: Obstetrics and Gynecology Department Khyber Teaching Hospital MTI Peshawar.
Duration of study: 5 years. From 1st January 2019 to 31st December 2023.
Materials and methods: This was a retrospective observational hospital-based study. Mothers who were admitted and died due to pregnancy-related causes were included in the study. Deaths due to accidental causes were excluded from the study. All the relevant information was extracted from the hospital records, labour registers, and maternal mortality register of the ward and was recorded on a pre-designed proforma. Descriptive statistics were used to calculate frequencies and percentages for different variables.
Results: Total numbers of live births during the study period were 19222 and total numbers of maternal deaths were 61. It gives the maternal mortality ratio of 317 per 100,000 live births. The majority of women (n=37-61%) were in the age groups of 31—40 years. Number of patients with great grand multiparty was 22(36%). All patients were un-booked with no proper ante-natal care received during pregnancy. Common causes of maternal mortality in descending order of frequency were eclampsia, post-partum hemorrhage, and ante-partum hemorrhage, all being preventable causes of death. Direct causes of death were seen in 50(82%) patients while 11 (18%) died due to indirect causes.
Conclusions: The maternal mortality ratio of 317 per 100,000 live births is quite high. The top 3 causes in our study are all preventable. We all have to work hard to reduce the maternal mortality ratio.
EXPLORING THE PHYSIOLOGICAL IMPACT OF EXCESSIVE SCREEN TIME ON THE MENTAL HEALTH OF YOUTH OF HYDERABAD, SINDH
Authors: Ansari Shafaq , Memon Roomi , Uddin Syed Farhan , Shah Hanozia , Suhag Ahmed Hussain , Mahnoor Syeda 
Published: January 2025

Background: The growing popularity of electronic devices in entertainment and education has encouraged young adults, especially adolescents, to spend more time in front of screens. There are growing incidences of anxiety, depression, and suicidal attempts among them. In 1990, 170 million people were suffering from depression, which rose to 270 million in 2019, accounting for a 64% rise in the prevalence of the disease.
Aims & Objectives: The objective of this study was to investigate link between increasing anxiety and depression among young adults and their duration of screen time exposure.
Material & Method: The current study was a survey-based study that was carried out at the Sindh University of Jamshoro from March 2024 to April 2024 (2 months) after obtaining ethical approval from the Physiology Department via latter no Physiol/77. The sample size was 550 participants in the 15- to 19-year-old age group. After written consent, a comprehensive and modified DASS 21 questionnaire was distributed among the participants, who were the students of Sindh University Jamshoro.
Results: The result shows increase in screen time contributes more to the incidence of anxiety and depression (P value 0.02, df: 2, x2 = 7.5), while excessive screen exposure at night is more contributory to anxiety and depression than daytime (df = 2, x2 = 6.9, P value = 0.03).
Conclusion: It was concluded that there is a definite link between excessive screen exposure and an increased ratio of anxiety and depression among adolescents.
GENETIC INFLUENCE OF CYP3A4 (rs2740574) GENE POLYMORPHISM ON CARBAMAZEPINE PHARMACOKINETICS IN EPILEPSY PATIENTS FROM KHYBER PAKHTUNKHWA: A PROSPECTIVE STUDY
Authors: Jamil Ayesha , Ali Niaz , Faisal Muhammad Saleh , Zaman Gulmakay , Yasmin Abida , Falah Shaikh Fahad 
Published: January 2025

Objectives: This study examines CYP3A genotypes regulating CYP enzymes, specifically CYP3A4 rs2740574, in Pashtun epilepsy patients in Khyber Pakhtunkhwa, Pakistan. This study documents the pharmacogenomic effects of this single nucleotide polymorphism on carbamazepine serum levels and dose-adjusted levels. It aims to promote customized medicine by providing insights that could lead to more effective epilepsy treatments for this population.
Methods: CYP3A4 (rs2740574) genotyping was performed on 223 patients using Sanger sequencing. DNA extraction was done by salting out method manually. In subsequent follow ups serum for separated for the detection of serum levels of Carbamazepine through HPLC. Finch TV identified gene polymorphisms, and HPLC examined their effects on plasma CBZ levels.
Results: Both TC (CYP3A4 *1A/*1B) and TT (CYP3A4*1B) genotypes had higher mean doses from the first to the second follow-up, with no statistically significant difference. Carbamazepine plasma levels increased by 0.70 ± 2.55 mg/L and CDR decreased by 0.41 mg/L per mg/kg/day among TT genotype carriers in the 2nd follow up. TT & CT were 96.4% & 3.6% whereas wild CC (CYP3A4 *1A/*1A) genotype was not encountered in the study sample.
Conclusion: Genotypes of the selected gene revealed a statistically insignificant correlation with Carbamazepine pharmacokinetics.
Examining the effects of virtual reality travel on tourist happiness and travel intentions using extended stimulus-organism-response theory: the perspective of Chinese tourists
Authors: Qian Zhang  , Zhaoqi Li  
Published: January 2025

The purpose of our study was to identify the psychological mechanisms through which VR presence and enjoyment influence travel intentions and explore how elements of different contexts (hedonic and utilitarian values) to influence travel experience satisfaction. We used Credamo to collect our data and used SPSS 28.0, AMOS 28.0, SPSS Process Macro to analyze the data. The results of analysis showed that VR presence and VR enjoyment positively influence travel experience satisfaction, which, in turn, boosts tourist happiness and positively influenced travel intention. Moderating effect indicate that utilitarian values strengthen the relationship between VR presence and travel experience satisfaction and hedonic values strengthen the relationship between VR enjoyment and travel experience satisfaction. In addition, this study potentially reveals the subtle interrelationships between various factors influencing tourists' behaviors. And it offers key insights into tourist psychology in VR-driven destination marketing.
Analisis Pendapatan Petani Cengkih di Desa Suluun Kecamatan Suluun Tareran Kabupaten Minahasa Selatan
Authors: Kurnia A. Antore  , Ita Pingkan F Rorong  , Hanly F.D Siwu  
Published: January 2025

Pertanian merupakan salah satu sektor yang penting dalam mendorong pertumbuhan ekonomi di daerah termasuk bisa menjadi pendorong roda perekonomian bangsa Indonesia. Sebagian besar masyarakat Indonesia khususnya masyarakat yang tinggal di pemukiman pedesaan mayoritas penduduknya bermata pencarian sebagai petani. Penelitian ini Bertujuan untuk Analisis Pendapatan Petani Cengkih Di Desa Suluun Kecamatan Suluun Tareran Sumber data yang digunakan dalam penelitian ini adalah data kuantitatif dan data kualitatif dengan sumber data yang digunakan yaitu data primer dan data sekunder. Penelitian ini menggunakan analisis Break Even Point. Hasil penelitian ini menunjukkan pencapaian titik impas dari petani. dari hasil yang di dapatkan dengan melakukan analisis pendapatan petani cengkih di kecamatan suluun tareran diketahui bahwa petani cengkih mampu meraih pendapatan rata-rata sebesar Rp 5,305,000 dengan titik Break Even mencapai tittik yang cukup sesuai dengan jumlah pendapatan petani. dalam setiap periode panen yang berlangsung selama tiga bulan. Dalam jangka waktu tersebut, para petani menghasilkan sekitar 250 kg cengkih, yang menjadi sumber utama pendapatan mereka.
(Im)pious Sisterhood: Maximus the Cynic’s Dangerous Liaisons
Authors: De Blasi Alessandro 
Published: January 2025

This paper focuses on analyzing Gregory of Nazianzus’ poem (II 1, 41) against his rival Maximus the Cynic, aiming to reconsider the role of women in Early Christianity from a gender-oriented perspective. In a specific passage (v. 49-53), the author appears to reference female assistants who allegedly supported Maximus’s betrayal, yet this allusion remains obscure and requires further investigation. Following a review of existing scholarship, the paper presents a new analysis and interpretation of the passage in view of a forthcoming critical edition of the entire poem. By placing this reference within a broader context and exploring parallels with female communities in Gregory’s works and contemporary patristic literature, it becomes evident that Gregory’s accusation is related to the emerging phenomenon of «syneisaktism». This thorough and updated analysis aims to achieve two main objectives. Firstly, it offers a new, more detailed, and culturally aware interpretation of the poem. Secondly, by examining its manuscript tradition, including its Syriac translation, it demonstrates the passage's corruption, thereby proposing a new conjecture.
Agricultural Policies in Nigeria: Impact on The Nigerian Economy
Authors: C Uche, , E. N Ajie, 
Published: January 2025

The study made use of secondary data accessed from bulletins and published researches whose primary focus was on various aspects of agricultural policies right from colonial rule to contemporary Nigeria and how it has impacted today’s agriculture and economy in the country. The research showed Nigeria hadn’t any explicit National Agricultural Policy before 1988. At independence in 1960, the country’s planning and policies mostly targeted economic growth and development and largely unarticulated administrative pronouncements that guided the operations of agricultural activities. The 1988 National Agricultural Policy document by the Federal Ministry of Agriculture and Natural Resources (FMARD) was an executive fiat of the then Federal Government that aimed at improving agricultural production and the development of export markets. A look at chronicled submissions in literature suggests Nigeria’s agricultural policy was replete with limitations, showed a general lack of coherence, absence of continuity and an inadequate linkage to other sectors of the economy. Events suggest agriculture related policies were opportunistic and uncoordinated and many scholars bemoan the absence of continuity and lessons from preceding program memes never adequately analyzed. These have made it difficult to track and evaluate policy effectiveness. At the institutional level, it is evident that roles are not clearly segregated among various administrative offices saddled with agricultural development. The study concluded that before the 1960s, the role of agriculture in Nigeria’s economy was of little interest. However, with limited support from the government, agriculture thrived and provided food for the population, raw materials for the industrial sector, revenue and foreign exchange for government and employment opportunities for the citizens. Agricultural policies in Nigeria will be a success if perspective plans and policy discipline are tenaciously held on to. This will enable government link past policies and facilitate an orderly transition ensuring a seamless continuity.
Complementary and Alternative Medicine Use among Dermatology Outpatients in Southeastern Nigeria: A Tertiary Hospital Study
Authors: Chioma Anaje Chetanna , Ifeanyi Okpala Chibuzor , Anne Enechukwu Nkechi , Ifeanyichukwu Ezejiofor Ogochukwu , Echezona Malachy Divinefavour , Chukwuebuka Nkesi John 
Published: January 2025

Background: Complementary and Alternative Medicine (CAM) is widely used globally, including among dermatology patients. CAM includes different practices not typically part of conventional medicine and is classified into five categories, including biologically based therapies and mind-body interventions. Despite its popularity, little is known about CAM usage patterns among dermatology outpatients in Southeastern Nigeria.
Aim: This study aimed to assess the prevalence, the sociodemographic characteristics of dermatology outpatients using CAM and reasons for its usage.
Study Design: Cross-sectional study.
Place and Duration of Study: Nnamdi Azikiwe University Teaching Hospital (NAUTH), Nnewi, Anambra State, Nigeria, between August to November 2022.
Methodology: We recruited 212 dermatology outpatients through convenient sampling. Data were collected using interviewer-administered structured questionnaires capturing sociodemographics, dermatological conditions, and CAM usage patterns.Data analysis was performed using SPSS™ Version 23.0, with chi-square tests determining associations between variables at a significance level of P < 0.05.
Results: Among 212 participants recruited, the prevalence of CAM use was 34.4%. The median age was 28 years, and more females (56.1%) than males (43.9%) used CAM. Acne (17.8%), psoriasis (16.4%), and mycoses (11%) were the most common conditions among CAM users. Biologically based therapies, particularly plant-based products like aloe vera, were the most frequently used CAM. Family recommendations (16%) and perceived safety (12.3%) were key reasons for CAM use. CAM usage was significantly associated with longer disease duration (P < .001).
Conclusion: The high prevalence of CAM use among dermatology outpatients in Southeastern Nigeria highlights the need for clinicians to recognize and consider alternative therapies in patient care. Understanding the patterns of CAM use can also guide clinicians in advising patients on safe and evidence-based alternatives. Future research on the efficacy and safety of CAM in dermatology is crucial to develop comprehensive, evidence-based treatment strategies that encompass both conventional and complementary therapies.
Application of genetic risk score for in-stent restenosis of second- and third-generation drug-eluting stents in geriatric patients
Authors: Hsu Yu-Ling , Huang Mu-Shiang , Chang Hsien-Yuan , Lee Cheng-Han , Chen Dao-Peng , Li Yi-Heng , Chao Ting-Hsin , Liu Yen-Wen , Liu Ping-Yen 
Published: July 2023

Abstract
Background
The second-and third-generation drug-eluting stents (DESs) in-stent restenosis (ISR) genetic risk score (GRS) model has been previously validated. However, the model has not been validated in geriatric patients. Therefore, we conducted this study to test the feasibility of the DES-ISR GRS model in geriatric patients with coronary artery disease (CAD) in Taiwan.

Methods
We conducted a retrospective, single-center cohort study and included geriatric patients (age ≥ 65 years) with CAD and second-or third-generation DES(s) deployment. Patients undergoing maintenance dialysis were excluded. ISR was defined as ≥ 50% luminal narrowing on the follow-up coronary arteriography. The DES-ISR GRS model included five selected exonic single-nucleotide polymorphisms (SNPs): CAMLG, GALNT2, C11orf84, THOC5, and SAMD11. The GRS was defined as the sum of the five selected SNPs for the risk allele.

Results
We enrolled 298 geriatric patients from January 2010 and December 2019 in this study. After propensity score matching, there were 192 geriatric patients with CAD in the final analysis, of which 32 patients had ISR. Patients were divided into two groups based on their GRS values: low (0–2) and high (≥ 3) GRS. A high GRS was significantly associated with DES-ISR in geriatric patients.

Conclusion
Those geriatric patients with a high GRS had significantly higher second-or third-generation DES ISR rates. The five SNP-derived DES-ISR GRS model could provide genetic information for interventional cardiologists to treat geriatric patients with CAD.

Trial registration
The primary study protocol was registered with clinicaltrials.org. with registration number: NCT03877614; on March 15, 2019. (http://clinicaltrials.gov/ct2/show/NCT03877614)
Some noncompact types of fixed point results in the generalized Banach spaces with respect to the G–weak topology contexts and applications
Authors: Laksaci Noura , Boudaoui Ahmed , Krichen Bilel , Mukheimer Aiman , Abdeljawad Thabet 
Published: July 2023

AbstractThis research deals with Krasnoselskii’s fixed point theorem where the entries operators do not need to be G-weakly compact and contraction. These results were obtained by using the so-called generalized measure of weak noncompactness and some user-friendly lemmas. Moreover, these gained fixed point results are applied to study the existence of solutions of a coupled system for integral equations in the generalized Banach space $\mathcal{{ C }} ( [0,1], E_{1} )\times \mathcal{{ C }} ( [0,1], E_{2} ) $
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Effect of contacts with health professionals on modern contraceptives uptake during the first 6 weeks after child birth: a prospective cohort study in Arsi Zone
Authors: Jima Gebi Husein , Stekelenburg Jelle , Fekadu Hailu , Sendekie Tegbar Yigzaw , Biesma Regien 
Published: July 2023

Abstract
Background
Healthy timing and spacing of pregnancy refers to the spacing between deliveries and subsequent pregnancies. The World Health Organization recommends waiting at least 24 months between the date of the live birth and the conception of the subsequent pregnancy in order to lower the risk of unfavorable maternal, perinatal, and newborn outcomes. Low use of contraception contributes to the high level of short inter-pregnancy intervals. Different studies conclusively demonstrate that this is a reality existing in Ethiopia right now. Limited data is available regarding the effects of contacts with health professionals on the use of contraception during the postnatal period.

Methods
A prospective cohort study was performed from October 01, 2020 to March 01, 2021. The study included 418 postnatal women who gave birth during the previous week. They were followed throughout the full postnatal period. A pre-tested structured questionnaire was used to gather the data. Data were gathered twice: once during the first week following birth and once again from the eighth to the 42nd day after birth. Epi-Info version 7 was used to enter data, which was subsequently exported to SPSS version 21 for analysis. The effect of contacts with health professionals where contraceptives were discussed on contraception uptake was measured using adjusted relative risk and its 95% confidence interval.

Results
Modern contraceptive uptake rate during the postnatal period was 16% (95% CI: 12.50-19.50%). Contraceptive use was 3.56 times more likely in women who were counseled about contraceptives during a contacts with health professionals at a health facility compared to those who did not have a contact (aRR = 3.56, 95% CI: 1.97–6.32). Women’s age, place of residence, knowledge of whether they can become pregnant before menses return, menses return after birth, and resuming sexual activity after birth were all significantly associated with contraceptive use during the first six weeks following child birth.

Conclusions
Modern contraceptive uptake rate during the postnatal period among women in the study area was low. Contacts with health professionals where contraception is discussed was the main factor associated with contraception uptake during the postnatal period. We recommend that the Arsi Zone Health Office, the Weardas Health Office in the Arsi Zone, and the health care providers in the Arsi Zone health facilities strengthen contraceptive counseling in postnatal health services to reduce the proportion of women with short inter-pregnancy intervals.
The Depiction of Al-Bukhārī’s travels in classical Islamic literature
Authors: Ghani Usman 
Published: July 2023

Travel (riḥla) after the death of the Prophet Muḥammad, and the geographically disparate locations of his companions made travelling for the acquisition of knowledge, and for the attainment of reliable ḥadīṯh an absolute necessity and it was regarded as a key component in the acquisition of this sacred knowledge. The present paper thus, investigates al-Bukhārī as a major figure in ḥadīṯh compilation. Furthermore, it discusses more specifically how he is perceived and exemplified in biographical literature (ṭabaqāt/tarājim). It subsequently, analyses the historical references (kutub al-tārīkh), in search of any possible subsidiary details. Finally, by providing a chronological listing of these sources and looking at the included and excluded details, also the possible and acceptable explanations of any incongruities befallen, the present paper will determine whether the information provided is consistent or if it is the subject of embellishment.Keywords: Riḥla, ḥadīṯh, al-Jāmi‘ al-Ṣaḥīḥ, ṭabaqāt, tarājim
PERAN KOPERASI BAITUL QIRADH BABURRAYYAN DALAM PEMBERDAYAAN PETANI KOPI GAYO DI DESA WIH NAREH KECAMATAN PEGASING KABUPATEN ACEH TENGAH
Authors: Kamari Samsul , Mahlil Mahlil , Fakhruddin Fakhruddin , Fatimah Fatimah 
Published: July 2023

Abstract: The Gayo highlands are one of the coffee-producing regions in Indonesia and the fourth largest exporter of coffee beans in the world, so a good strategy and plan is needed to improve people's welfare through Gayo coffee commodities, one of which is through cooperatives such as the Qiradh Baburrayyan Cooperative for farmers who in Wih Nareh Village, Pegasing District. The purpose of this study was to find out the process of empowering Gayo coffee farmers that was carried out by KBQ Baburrayyan and the obstacles faced in empowering Gayo Coffee Farmers. This study uses a qualitative method with a descriptive approach. Data collection was carried out by interviews, observation, and documentation. The results of the research show that the role of KBQ Baburrayyan in empowering Gayo coffee farmers in Wih Nareh Village, Pegasing District, Central Aceh District has been going quite well. Wih Nareh Village so that the unemployment rate decreased. Then provide guidance to the community such as training and outreach. Furthermore, the Baitul Qiradh Baburrayyan Cooperative also provided seed assistance other than coffee because coffee has a harvest pause period to support the coffee farmers' economy.Keywords: The Role of Cooperatives; Empowerment; Coffee Farmers.Abstrak: Daratan tinggi Gayo merupakan salah satu daerah penghasil kopi di Indonesia dan pengekspor biji kopi terbesar keempat di dunia sehingga dibutuhkan strategi maupun rencana yang baik dalam meningkatkan kesejahteraan masyarakat melalui komoditas kopi gayo, salah satunya melalui koperasi seperti yang dilakukan pihak Koperasi Baitul Qirad Baburrayyan kepada para petani yang ada di Desa Wih Nareh Kecamatan Pegasing. Tujuan dari penelitian ini adalah untuk mengetahui proses pemberdayaan petani kopi gayo yang dilakukan KBQ Baburrayyan serta kendala yang dihadapi dalam melakukan pemberdayaan terhadap Petani Kopi Gayo. Penelitian ini menggunakan metode kualitatif dengan pendekatan deskriptif. Pengambilan data dilakukan dengan wawancara, observasi, dan dokumentasi. Hasil penelitian menunjukkan bahwa Peran KBQ Baburrayyan dalam pemberdayaan petani kopi Gayo di Desa Wih Nareh Kecamatan Pegasing Kabupaten Aceh Tengah telah berjalan cukup baik terlihat dari adanya beberapa program pemberdayaan yang saat ini sedang berlangsung yaitu dengan merangkul tenaga kerja dan anggota kelompok tani dari masyarakat yang ada di Desa Wih Nareh sehingga angka pengangguran menurun. Kemudian melakukan bimbingan kepada masyarakat seperti pelatihan dan sosialisasi. Selanjutnya pihak Koperasi Baitul Qiradh Baburrayyan juga memberi bantuan bibit selain kopi karena kopi memiliki masa jeda panen tujuannya agar menunjang perekonomian petani kopi tersebut.Kata Kunci: Peran Koperasi; Pemberdayaan; Petani Kopi.