bluuebunny/crossref_metadata_2025_split huggingface dataset:
Standard: Human intestinal organoids
Authors: Wang Yalong , Lin Hanqing , Zhao Lianzheng , Hong Fan , Hao Jie , Zhang Zhen , Sheng Weiqi , Song Linhong , Deng Chu-Xia , Zhao Bing , Cao Jiani , Wang Lei , Wang Liu , Liang Lingmin , Chen Wenli Kelly , Yu Chunping , Sun Zhijian , Yang Yingying , Wang Changlin , Zhang Yong , Li Qiyuan , Li Ka , Ma Aijin , Zhao Tongbiao , Hua Guoqiang , Chen Ye-Guang 
Published: June 2023

AbstractOrganoids have attracted great interest for disease modelling, drug discovery and development, and tissue growth and homeostasis investigations. However, lack of standards for quality control has become a prominent obstacle to limit their translation into clinic and other applications. “Human intestinal organoids” is the first guideline on human intestinal organoids in China, jointly drafted and agreed by the experts from the Chinese Society for Cell Biology and its branch society: the Chinese Society for Stem Cell Research. This standard specifies terms and definitions, technical requirements, test methods, inspection rules for human intestinal organoids, which is applicable to quality control during the process of manufacturing and testing of human intestinal organoids. It was originally released by the Chinese Society for Cell Biology on 24 September 2022. We hope that the publication of this standard will guide institutional establishment, acceptance and execution of proper practical protocols and accelerate the international standardization of human intestinal organoids for applications.
Advancing positive social determinants of health through collective impact and the 100% New Mexico Model
Authors: McCrae Julie S. , Spain Angeline K. 
Published: June 2023

Abstract
Background
Communities across the U.S. and globally confront the challenge of transforming negative social determinants of health (SDOH) into positive ones. To address this complex social problem, the collective impact (CI) approach has promise but has been critiqued for insufficiently challenging structural inequities. Research applying CI to SDOH is limited. This mixed-methods study examined early adoption of CI in the 100% New Mexico initiative that aims to address SDOH population-wide in a state with strong cultural identity and assets but also persistent socio-economic inequality.

Methods
A web-based survey, interviews and focus groups were conducted with initiative participants in June and July 2021. Survey participants rated agreement on a 4-point scale with six items assessing CI foundation adapted from the Collective Impact Community Assessment Scale. Interviews and focus groups centered on motivation to engage, progress achieved in model components, CI core conditions, and contextual factors influencing experiences. Surveys were analyzed using descriptive means and proportions. Qualitative data were analyzed using thematic analysis and an inductive approach followed by stratified analyses and co-interpretation of emergent findings with model developers.

Results
Fifty-eight participants completed the survey, and 21 individuals participated in interviews (n = 12) and two focus groups (n = 9). Survey mean scores were highest related to initiative buy-in and commitment, and lower related to shared ownership, having multiple perspectives and voices involved, and adequate resources. Qualitative results showed that the framework’s cross-sector emphasis helped motivate participation. Participants embraced the focus on leveraging existing community assets that is characteristic of CI and the current framework. Counties implemented effective engagement and visibility strategies including mural projects and book clubs. Participants expressed communication challenges across county sector teams which influenced feelings of accountability and ownership. Participants did not report challenges lacking relevant, available, and timely data or tension between funder-driven and community-driven desired outcomes, in contrast with previous CI research.

Conclusion
Multiple foundational conditions of CI were supported in 100% New Mexico, including evidence for support of the common agenda addressing SDOH, shared measurement framework, and mutually reinforcing activities. Study results suggest that efforts to launch CI to address SDOH, which is by nature multi-sector, should include robust strategies to address communication needs of local teams. The use of community-administered surveys to identify gaps in SDOH resource access contributed to ownership and a sense of collective efficacy that may portend sustainability; however, relying on volunteers in the absence of other resources extensively also threatens sustainability.
Tele-dentistry, its trends, scope, and future framework in oral medicine; a scoping review during January 1999 to December 2021
Authors: Niknam Fatemeh , Sharifian Roxana , Bashiri Azadeh , Mardani Maryam , Akbari Reza , Tuffaha Haitham , Do Loc , Bastani Peivand 
Published: June 2023

AbstractBackgroundTele-dentistry has been increasingly used for different purposes of visit, consultation, triage, screening, and training in oral medicine. This study aims to determine the main facilitators, barriers, and participants` viewpoints of applying tele-dentistry in oral medicine and develop a framework indicating the input, process, output, and feedback.MethodThis was a scoping review conducted in 2022 applying Arksey and O’Malley (2005) approach. Four databases including ISI web of science, PubMed, Scopus, and ProQuest were searched from January 1999 to December 2021. Inclusion criteria consisted of all original and non-original articles (reviews, editorials, letters, comments, and book chapters), and dissertations in English with a full text electronic file. Excel2016was used for descriptive quantitative analysis and MAXQDA version 10 was applied for qualitative thematic analysis. A thematic framework was developed customizing the results of the review in a virtual mini expert panel.ResultsDescriptive results show that among 59 included articles, 27 (46%) have addressed the various applications of tele-dentistry during COVID-19 pandemic in the field of oral medicine. From geographical distribution perspective, most of the papers were published in Brazil (n = 13)/ 22.03%, India (n = 7)/11.86% and USA (n = 6)/10.17%. Thematic analysis shows that seven main themes of “information”, “skill”, “human resource”, ‘technical”, “administrative’, ‘financial’, and ‘training and education’ are explored as facilitators. ‘Individual’, ‘environmental’, ‘organizational’, ‘regulation’, ‘clinical’, and ‘technical barriers’ are also identified as main barriers of tele-dentistry in oral medicine.ConclusionAccording to the results for using tele-dentistry services in oral medicine, a diverse category of facilitators should be considered and at the same time, different barriers should be managed. Users` satisfaction and perceived usefulness of tele-dentistry as final outcomes can be increased considering the system`s feedback and applying facilitator incentives as well as decreasing the barriers.
Exploring animal husbandry in smallholder dairy systems in Ethiopia using photovoice
Authors: Nyokabi Ndungu S. , Phelan Lisette , Gemechu Gizachew , Berg Stefan , Mihret Adane , Wood James L. N. , Moore Henrietta L. 
Published: June 2023

AbstractThis study uses photovoice to explore smallholder dairy farmers’ husbandry knowledge and practices and document how they address constraints faced in pursuing their livelihood strategy. Currently, there is a paucity of farmer-led research in Ethiopia which captures farmers’ local knowledge and lived experiences.This study was conducted in April and May 2021 in Kaliti, a sub-city of Addis Ababa, and Holeta, located near Addis Ababa, in the Oromia region of Ethiopia. Farmers were selected through purposive and snowball sampling approaches based on their previous participation in a bovine tuberculosis study. Farmers selection was based on their experience in dairy farming and willingness to attend research-related meetings and to engage in photo-taking and subsequent group discussions. Farmers were trained on the use of the digital camera and asked to take pictures of their day-to-day activities, challenges faced in pursuing dairy production and how they overcome these challenges.The pictures taken by farmers indicated their attachment to their cattle, cattle disease symptoms, manure management, pest control practices, cattle housing, feeding practices, milking hygiene and storage. Discussions revealed that husbandry challenges faced stemmed from land-use change, declining farm sizes, poor access to veterinary and animal health services, low milk prices and high cattle feed prices. Farmers explained that they had developed knowledge of cattle nutrition, such as feed ration mixing and ways to deal with manure problems. The results of this study underscore that farmers have a good understanding of husbandry challenges and, additionally, have a wealth of local knowledge which can be leveraged, if captured through participatory and visual research methods, such as photovoice, by policymakers to develop context-aware policies and interventions and recommendations regarding improved practices which are economically viable, and socially and culturally acceptable.
Narratives to revert overconsumption: human-nature interdependence and Circular Economy
Authors: Borrello M. , Cembalo L. , D’Amico V. 
Published: June 2023

AbstractPolicy and practitioners’ initiatives to stimulate sustainable consumption have so far failed to have notable impact on individuals’ behaviors. The current commentary is a plea to social and sustainability scientists, particularly to economists dealing with sustainable agri-food systems, to dig deeper into the notion of narratives to trigger societal dynamics that stir consumers toward more sufficient lifestyles. As dominant cultural narratives have a critical role in shaping shared meanings and acceptable behaviors, in the future they could guide dramatic changes in individuals’ conduct, triggering drastic modifications of current consumption patterns. Based on the power that concepts as the Circular Economy and the Anthropocene have had in the recent past, a future step to develop an ecological worldview across society, and nourish individual identities deeply committed with the preservation of natural ecosystems, is working on narratives based on the notion of human-nature interdependence.
A novel 3-miRNA network regulates tumour progression in oral squamous cell carcinoma
Authors: Patel Aditi , Patel Parina , Mandlik Dushyant , Patel Kaustubh , Malaviya Pooja , Johar Kaid , Swamy Krishna B.S , Patel Shanaya , Tanavde Vivek 
Published: June 2023

Abstract
Background
Late diagnosis is one of the major confounders in oral squamous cell carcinoma (OSCC). Despite recent advances in molecular diagnostics, no disease-specific biomarkers are clinically available for early risk prediction of OSCC. Therefore, it is important to identify robust biomarkers that are detectable using non-invasive liquid biopsy techniques to facilitate the early diagnosis of oral cancer. This study identified potential salivary exosome-derived miRNA biomarkers and crucial miRNA-mRNA networks/underlying mechanisms responsible for OSCC progression.

Methods
Small RNASeq (n = 23) was performed in order to identify potential miRNA biomarkers in both tissue and salivary exosomes derived from OSCC patients. Further, integrated analysis of The Cancer Genome Atlas (TCGA) datasets (n = 114), qPCR validation on larger patient cohorts (n = 70) and statistical analysis with various clinicopathological parameters was conducted to assess the effectiveness of the identified miRNA signature. miRNA-mRNA networks and pathway analysis was conducted by integrating the transcriptome sequencing and TCGA data. The OECM-1 cell line was transfected with the identified miRNA signature in order to observe its effect on various functional mechanisms such as cell proliferation, cell cycle, apoptosis, invasive as well as migratory potential and the downstream signaling pathways regulated by these miRNA-mRNA networks.

Results
Small RNASeq and TCGA data identified 12 differentially expressed miRNAs in OSCC patients compared to controls. On validating these findings in a larger cohort of patients, miR-140-5p, miR-143-5p, and miR-145-5p were found to be significantly downregulated. This 3-miRNA signature demonstrated higher efficacy in predicting disease progression and clinically correlated with poor prognosis (p < 0.05). Transcriptome, TCGA, and miRNA-mRNA network analysis identified HIF1a, CDH1, CD44, EGFR, and CCND1 as hub genes regulated by the miRNA signature. Further, transfection-mediated upregulation of the 3-miRNA signature significantly decreased cell proliferation, induced apoptosis, resulted in G2/M phase cell cycle arrest and reduced the invasive and migratory potential by reversing the EMT process in the OECM-1 cell line.

Conclusions
Thus, this study identifies a 3-miRNA signature that can be utilized as a potential biomarker for predicting disease progression of OSCC and uncovers the underlying mechanisms responsible for converting a normal epithelial cell into a malignant phenotype.
Fall migration, oceanic movement, and site residency patterns of eastern red bats (Lasiurus borealis) on the mid-Atlantic Coast
Authors: True Michael C. , Gorman Katherine M. , Taylor Hila , Reynolds Richard J. , Ford W. Mark 
Published: June 2023

AbstractAlong the mid-Atlantic coast of the United States, eastern red bats (Lasiurus borealis) are present during fall mating and migration, though little is currently known about most aspects of bat migration. To reveal migration patterns, and understand drivers of over-water flight, we captured and radio-tagged 115 eastern red bats using novel technology, and subsequently tracked and described their movements throughout the region. We compared over-water flight movements to randomly generated patterns using a use-availability framework, and subsequently used a generalized linear mixed effects model to assess the relationship of over-water flight to atmospheric variables. We used hidden Markov models to assess daily activity patterns and site residency. Most bats with long-distance movements traveled in a southwesterly direction, however path vectors were often oriented interior toward the continental landmass rather than along the coastline. We observed that some bats transited wide sections of the Chesapeake and Delaware bays, confirming their ability to travel across large water bodies. This over-water flight typically occurred in the early hours of the night and during favorable flying conditions. If flight over large water bodies is a proxy for over-ocean flight, then collision risk at offshore wind turbines – a major source of migratory bat fatalities – may be linked nightly to warm temperatures that occur early in the fall season. Risk, then, may be somewhat predictable and manageable with mitigation options linking wind-energy operation to weather conditions and seasonality.
Visualising varnish removal for conservation of paintings by fluorescence lifetime imaging (FLIM)
Authors: Wilda Christine B. , Burnstock Aviva , Suhling Klaus , Mattioli Della Rocca Francesco , Henderson Robert K. , Nedbal Jakub 
Published: June 2023

Abstract
The removal of varnish from the surface is a key step in painting conservation. Varnish removal is traditionally monitored by examining the painting surface under ultraviolet illumination. We show here that by imaging the fluorescence lifetime instead, much better contrast, sensitivity, and specificity can be achieved. For this purpose, we developed a lightweight (4.8 kg) portable instrument for macroscopic fluorescence lifetime imaging (FLIM). It is based on a time-correlated single-photon avalanche diode (SPAD) camera to acquire the FLIM images and a pulsed 440 nm diode laser to excite the varnish fluorescence. A historical model painting was examined to demonstrate the capabilities of the system. We found that the FLIM images provided information on the distribution of the varnish on the painting surface with greater sensitivity, specificity, and contrast compared to the traditional ultraviolet illumination photography. The distribution of the varnish and other painting materials was assessed using FLIM during and after varnish removal with different solvent application methods. Monitoring of the varnish removal process between successive solvent applications by a swab revealed an evolving image contrast as a function of the cleaning progress. FLIM of dammar and mastic resin varnishes identified characteristic changes to their fluorescence lifetimes depending on their ageing conditions. Thus, FLIM has a potential to become a powerful and versatile tool to visualise varnish removal from paintings.

Graphical Abstract
Modelling of hygro-mechanical behaviour of wooden panel paintings: model calibration and artworks characterisation
Authors: Riparbelli Lorenzo , Mazzanti Paola , Helfer Thomas , Manfriani Chiara , Uzielli Luca , Castelli Ciro , Santacesaria Andrea , Ricciardi Luciano , Rossi Sandra , Gril Joseph , Fioravanti Marco 
Published: June 2023

Abstract
Wooden Panel Paintings (WPP) are among the most significant historical and artistic artifacts from the Middle Ages and Renaissance and pose a challenge to conservators and scientists in both their comprehension and conservation. From a structural point of view, they can be considered as multi-layered objects, consisting of a wooden support and several pictorial layers. The wooden support, hygroscopic in nature, constantly seeks equilibrium with the humidity of the environment, and consequently deforms. Based on a series of hygroscopic tests carried out on six original WPPs, the present work aims to model their deformation tendencies induced by moisture changes and to characterise them by means of an inverse identification process. The sensitivity analysis of this study provided valuable insights into the complexity of the phenomenon of WPP deformation: even small variations in input variables (board anatomy, stiffness and emissivity of pictorial layers) led to significant changes in the deformation trend over time, highlighting the high variability of the physical problem under investigation. Sobol's analysis variance confirmed this complexity, demonstrating the different levels of influence of input variables and the existence of interactions between them. Overall, the results of this analysis highlighted the need to carefully evaluate the interactions and uncertainties in input variables to fully understand the complexity of the system. The iterative optimization process led to numerical results tending to agree with experimental data, with most results showing a very high correlation. This suggests that the chosen variables and modelling assumptions sufficiently described the physical system and that numerical models can be accurately calibrated. The proposed concept of 'learning from objects', by conducting experimental investigations specifically dedicated to understanding the deformation tendencies of the artwork, is essential. In this approach, numerical analysis is used in conjunction with experiments to gain a deeper understanding of the artwork, characterise it and extract valuable information.
Neonatal necrotizing fasciitis with gas gangrene due to peripherally inserted central catheter-related infection
Authors: Okamoto Mitsumasa , Tsuruno Yudai , Fukuzawa Hiroaki 
Published: June 2023

Abstract
Background
Necrotizing fasciitis in neonates is a rare and life-threatening infection involving necrosis of the skin, subcutaneous tissues, deep fascia, and sometimes underlying muscles, with a fulminant course and high mortality rate. Necrotizing fasciitis with gas gangrene related to infection of a peripherally inserted central catheter is very rare.

Case presentation
The patient was a full-term female neonate born by vaginal delivery. Following diagnosis of patent ductus arteriosus, indomethacin was administered from a peripherally inserted central catheter for 3 days. Four days after the termination of medical treatment for the patent ductus arteriosus, the patient developed fever and a severely elevated inflammatory response was identified from blood testing. Around the right anterior chest wall, corresponding to the site of the catheter tip, redness was increased and gas crepitus was felt under the skin. Computed tomography revealed emphysema in the anterior chest, in subcutaneous areas and between muscles. Emergency surgical debridement was performed under a diagnosis of necrotizing fasciitis with gas gangrene. With antibiotic treatment, we started to fill the wound with a dialkyl carbamoyl chloride-coated dressing and povidone-iodine sugar ointment after washing with saline once a day. The patient survived and after 3 weeks of treatment with the dressing, the wound had successfully resolved without motor impairments.

Conclusions
In addition to medical treatment and prompt surgical debridement, we used dialkyl carbamoyl chloride-coated dressing and povidone-iodine sugar ointment for antiseptic dressings and successfully treated neonatal necrotizing fasciitis with gas gangrene caused by peripherally inserted central catheter infection with Citrobacter koseri.
Laparoscopic Heller myotomy and Dor fundoplication following an unsuccessful peroral endoscopic myotomy
Authors: Aoki Takuma , Ozawa Soji , Hayashi Koki , Ando Tomofumi , Uchi Yusuke , Shimazu Motohide , Shinozaki Hiroharu , Matsumoto Kenji , Omura Nobuo 
Published: June 2023

Abstract
Background
Achalasia is an esophageal motility disorder that presents as dysphagia and severely affects quality of life. An esophageal myotomy has been the golden standard for treatment. Peroral endoscopic myotomy (POEM) as a first-line therapy has an acceptable outcome. However, after the clinical failure of POEM, appropriate second-line therapy is rather controversial. Here, we present the first published case in English of a patient who was successfully treated using laparoscopic Heller myotomy (LHM) with Dor fundoplication following an unsuccessful POEM.

Case presentation
A 64-year-old man with type 1 achalasia who had been previously treated with POEM visited our hospital for further treatment. After undergoing LHM with Dor fundoplication, his Eckardt score improved from 3 to 0 points. On a timed barium esophagogram (TBE), the barium height improved from 119 mm/119 mm (1 min/5 min) to 50 mm/45 mm. No significant complications have occurred postoperatively for 1 year.

Conclusion
Treating refractory achalasia is challenging, and treatment options are controversial. LHM with Dor fundoplication after POEM could be a safe and efficient option for the treatment of refractory achalasia.