bluuebunny/crossref_metadata_2025_split huggingface dataset:
Zinc Chelate Complexes of N‐Acyl Hydrazones as Substrates for Addition of Alkyl and Fluorinated Radicals
Authors: Rubanov Zakhar M. , Levin Vitalij V. , Dilman Alexander D. 
Published: July 2023

AbstractZinc chelate complexes can be generated in situ from N‐acyl hydrazones by treatment with isopropyl zinc iodide. These complexes couple with alkyl and fluorinated radicals under photoredox conditions. Alkyl radicals were generated from organozinc halides using an organic photocatalyst and afford hydrazines as a result of reductive mode of addition. Fluorinated radicals were formed from perfluorinated alkyl iodides under photoredox conditions leading to fluoroalkylated hydrazones via neutral reaction pathway.
A Generic Platform for Upcycling Polystyrene to Aryl Ketones and Organosulfur Compounds
Authors: Munyaneza Nuwayo Eric , Posada Carlos , Xu Zhen , De Altin Popiolek Vincenzo , Paddock Griffin , McKee Charles , Liu Guoliang 
Published: July 2023

AbstractPolystyrene (PS) is one of the least recycled large‐volume commodity plastics due to bulkiness of foam products and associated contaminants. PS recycling is also severely hampered by the lack of financial incentive, limited versatility, and poor selectivity of existing methods. To this end, herein we report a thermochemical recycling strategy of “degradation‐upcycling” to synthesize a library of high‐value aromatic chemicals from PS wastes with high versatility and selectivity. Two cascade reactions are selected to first degrade PS to benzene under mild temperatures, followed by the derivatization thereof utilizing a variety of acyl/alkyl and sulfinyl chloride additives. To demonstrate the versatility, nine ketones and sulfides of cosmetic and pharmaceutical relevance were prepared, including propiophenone, benzophenone, and diphenyl sulfide. The approach is also amenable to sophisticated upcycling reaction designs and can produce desired products stepwise. The facile and versatile approach will provide a scalable and profitable methodology for upcycling PS waste into value‐added chemicals.
A Porous Crystalline Nitrone‐Linked Covalent Organic Framework**
Authors: Kurandina Daria , Huang Banruo , Xu Wentao , Hanikel Nikita , Darù Andrea , Stroscio Gautam D. , Wang Kaiyu , Gagliardi Laura , Toste F. Dean , Yaghi Omar M. 
Published: July 2023

AbstractHerein, we report the synthesis of a nitrone‐linked covalent organic framework, COF‐115, by combining N, N′, N′, N′′′‐(ethene‐1, 1, 2, 2‐tetrayltetrakis(benzene‐4, 1‐diyl))tetrakis(hydroxylamine) and terephthaladehyde via a polycondensation reaction. The formation of the nitrone functionality was confirmed by solid‐state 13C multi cross‐polarization magic angle spinning NMR spectroscopy of the 13C‐isotope‐labeled COF‐115 and Fourier‐transform infrared spectroscopy. The permanent porosity of COF‐115 was evaluated through low‐pressure N2, CO2, and H2 sorption experiments. Water vapor and carbon dioxide sorption analysis of COF‐115 and the isoreticular imine‐linked COF indicated a superior potential of N‐oxide‐based porous materials for atmospheric water harvesting and CO2 capture applications. Density functional theory calculations provided valuable insights into the difference between the adsorption properties of these COFs. Lastly, photoinduced rearrangement of COF‐115 to the associated amide‐linked material was successfully demonstrated.
Sorting out journals: The proliferation of journal lists in China
Authors: Wang Jing , Halffman Willem , Zhang Yuehong Helen 
Published: July 2023

AbstractJournal lists are instruments to categorize, compare, and assess research and scholarly publications. Our study investigates the remarkable proliferation of such journal lists in China, analyses their underlying values, quality criteria and ranking principles, and specifies how concerns specific to the Chinese research policy and publishing system inform these lists. Discouraged lists of “bad journals” reflect concerns over inferior research publications, but also the involved drain on public resources. Endorsed lists of “good journals” are based on criteria valued in research policy, reflecting the distinctive administrative logic of state‐led Chinese research and publishing policy, ascribing worth to scientific journals for its specific national and institutional needs. In this regard, the criteria used for journal list construction are contextual and reflect the challenges of public resource allocation in a market‐led publication system. Chinese journal lists therefore reflect research policy changes, such as a shift away from output‐dominated research evaluation, the specific concerns about research misconduct, and balancing national research needs against international standards, resulting in distinctly Chinese quality criteria. However, contrasting concerns and inaccuracies lead to contradictions in the “qualify” and “disqualify” binary logic and demonstrate inherent tensions and limitations in journal lists as policy tools.
Design and development of opto‐electrochemical biosensing devices for diagnosing chronic kidney disease
Authors: Divya  , Darshna  , Sammi Aditi , Chandra Pranjal 
Published: July 2023

AbstractChronic kidney disease (CKD) is emerging as one of the major causes of the increase in mortality rate and is expected to become 5th major cause by 2050. Many studies have shown that it is majorly related to various risk factors, and thus becoming one of the major health issues around the globe. Early detection of renal disease lowers the overall burden of disease by preventing individuals from developing kidney impairment. Therefore, diagnosis and prevention of CKD are becoming the major challenges, and in this situation, biosensors have emerged as one of the best possible solutions. Biosensors are becoming one of the preferred choices for various diseases diagnosis as they provide simpler, cost‐effective and precise methods for onsite detection. In this review, we have tried to discuss the globally developed biosensors for the detection of CKD, focusing on their design, pattern, and applicability in real samples. Two major classifications of biosensors based on transduction systems, that is, optical and electrochemical, for kidney disease have been discussed in detail. Also, the major focus is given to clinical biomarkers such as albumin, creatinine, and others related to kidney dysfunction. Furthermore, the globally developed sensors for the detection of CKD are discussed in tabulated form comparing their analytical performance, response time, specificity as well as performance in biological fluids.
Passage number of cancer cell lines: Importance, intricacies, and way‐forward
Authors: Prasad Chandra Prakash , Tripathi Satyendra Chandra , Kumar Manish , Mohapatra Purusottam 
Published: July 2023

AbstractCancer cell lines play a crucial role as invaluable models in cancer research, facilitating the examination of cancer progression as well as the advancement of diagnostics and treatments. While they may not perfectly replicate the original tumor, they generally exhibit similar characteristics. Low‐passage cancer cell lines are generally preferred due to their closer resemblance to the original tumor, as long‐term culturing can alter the genetic and molecular profiles of a cell line thereby highlighting the importance of monitoring the passage number (PN). Variations in proliferation, migration, gene expression, and drug sensitivity can be linked to PN differences. PN can also influence DNA methylation levels, metabolic profiles, and the expression of genes/or proteins in cancer cell lines. When conducting research on cancer cell lines, it is crucial for researchers to carefully select the appropriate PN to maintain consistency and reliability of results. Moreover, to ensure dependability and replicability, scientists ought to actively track the growth, migration, and gene/or protein profiles of cancer cell lines at specific PNs. This approach enables the identification of the most suitable range of PNs for experiments, guaranteeing consistent and precise results. Additionally, such efforts serve to minimize disparities and uphold the integrity of research. In this review, we have laid out recommendations for laboratories to overcome these PN discrepancies when working with cancer cell lines.
A short screening tool identifying systemic barriers to distress screening in cancer care
Authors: Simnacher Felice , Götz Anna , Kling Sabine , Schulze Jan Ben , von Känel Roland , Euler Sebastian , Günther Moritz Philipp 
Published: July 2023

AbstractIntroductionInternational guidelines on cancer treatment recommend screening for early detection and treatment of distress. However, screening rates are insufficient. In the present study, a survey was developed to assess perceived systemic barriers to distress screening.MethodsA three‐step approach was used for the study. Based on qualitative content analysis of interviews and an expert panel, an initial survey with 53 questions on barriers to screening was designed. It was completed by 98 nurses in a large comprehensive cancer center in Switzerland. From this, a short version of the survey with 24 questions was derived using exploratory principal component analysis. This survey was completed by 150 nurses in four cancer centers in Switzerland. A confirmatory factor analysis was then performed on the shortened version, yielding a final set of 14 questions.ResultsThe initial set of 53 questions was reduced to a set of 14 validated questions retaining 53% of the original variance. These 14 questions allow for an assessment within 2–3 min that identifies relevant barriers to distress screening from the perspective of those responsible for implementation of distress screening. Across several hospitals in Switzerland, the timing of the first distress screening, lack of capacity, patient and staff overload, and refusal of distressed patients to be referred to support services emerged as major problems.ConclusionThe validated 14 questions on barriers to screening cancer patients for distress enable clinicians and hospital administrators to quickly identify relevant issues and take action to improve screening programs.
FAM60A promotes osteosarcoma development and progression
Authors: Sun Yu , Man Yu‐Nan , Cheng Jin‐hui , Li Jing‐tang , Liu Ya‐yun 
Published: July 2023

AbstractBackgroundOsteosarcoma (OS) is a highly malignant primary bone tumor. Family of homology 60A (FAM60A) reportedly contributes to the malignant growth of some tumors.MethodsHerein we investigated the mRNA expression level of FAM60A by combining OS and non‐cancer samples from public databases. Immunohistochemistry was performed to determine protein expression levels of FAM60A in patients with OS. Further, RT‐qPCR and western blotting were conducted to evaluate FAM60A expression in various OS cell lines. CCK‐8 assay, colony formation assay, and flow cytometry were applied to determine the function of FAM60A. Finally, functional enrichment analysis was performed based on FAM60A co‐expressed genes.ResultsFAM60A mRNA expression level was found to be significantly upregulated (standardized mean difference = 1.27, 95% CI [0.67–1.88]). Survival analyses suggested that higher expression of FAM60A was indicative of poor prognoses. Similarly, FAM60A protein expression level was also observed to be upregulated. Knocking down FAM60A expression inhibited OS cell proliferation, increased apoptosis, and blocked cells from entering the S phase. Besides, cell cycle was the most prominently enriched pathway, and BUB1, DTL, and EXO1 were identified as hub genes.ConclusionsFAM60A expression was found to be markedly upregulated in OS; furthermore, FAM60A was observed to promote OS cell proliferation, inhibit apoptosis, and participate in cell cycle regulation. Besides, FAM60A may interact with hub genes to participate in the progress of OS.
Prevention of Swelling Phenomenon of Alginate Beads To Improve the Stability and Recyclability of Encapsulated Horse Liver Alcohol Dehydrogenase
Authors: Vetrano Alice , Gabriele Francesco , Spreti Nicoletta 
Published: July 2023

AbstractHorse Liver Alcohol Dehydrogenase (HLADH) has been immobilized on calcium‐alginate beads and used for both oxidation and reduction reactions. To avoid swelling of the beads and their subsequent breakage, calcium ions were added to both reaction and storage solutions, allowing the beads to maintain the initial structural features. The techniques used for this purpose revealed that 2 mM Ca2+ is the optimal concentration, which does not significantly change the weight of the beads, the amount of water in them, and their external and internal structure. The optimized experimental procedure has been used to verify the properties of the enzyme in terms of reusability, storage, and thermal stability. The addition of calcium ions allows the enzyme to retain more than 80 % of its initial activity for fourteen cycles and approximately 50 % at the twentieth cycle. Moreover, when the biocatalyst has been stored in a buffer solution containing 2 mM Ca2+, the retention of enzyme activity after 30 days was 100 %, compared to that measured before incubation. The encapsulated enzyme exhibits greater thermal stability than free HLADH up to at least 60 °C, preventing dimer dissociation into the two subunits.
An HIV‐positive woman with massive brain lesion due to toxoplasmosis: A case report
Authors: Ghasemikhah Reza , Hakimzadeh Zahra , Gilani Abolfazl , Sarmadian Hossein , Sarmadian Roham , Yousefbeigi Negin 
Published: July 2023

Key Clinical MessageToxoplasmosis‐related huge brain lesions may require decompressive craniectomy and lesion excision to avoid brain damage. In this situation, injectable cotrimoxazole is a better choice for treatment.AbstractToxoplasma gondii is a worldly distributed obligate intracellular protozoa. Toxoplasmosis is a prevalent opportunistic infection in HIV‐infected people, but it was rarely recorded prior to the identification of HIV infection. Here, we report a toxoplasmosis brain lesion in an Iranian HIV‐positive patient. A 45‐year‐old woman with a complaint of malaise was referred to the Valiasr Hospital in Arak city. In her past clinical history, the patient had a history of anemia, deep vein thrombosis (DVT), and positive HIV. The patient was informed of the diagnosis of massive brain toxoplasmosis as a definite diagnosis. The patient was then taken to the operating room for a left decompressive craniectomy, during which the ensuing brain lesion was excised. After a few days, she was discharged from the hospital in good condition and without any complications.
Direct Arylation Polycondensation of Thiophene‐Based C−H Monomers†
Authors: Zhang Xuwen , Shi Yibo , Deng Yunfeng , Geng Yanhou 
Published: July 2023

Comprehensive SummaryDirect arylation polycondensation (DArP) has emerged as an eco‐friendly and atom‐efficient methodology for the syntheses of π‐conjugated polymers (CPs). This approach features the direct C—H arylation of an aromatic hydrocarbon with an aryl halide. Given the prevalence of thiophene‐containing CPs, achieving efficient and defect‐free DArP of thiophene‐based C−H monomers is of great significance. This review presents a mechanistic insight into DArP and describes the development of DArP catalytic systems for varied thiophene‐based C−H monomers. Moreover, the control of the primary defects (i.e., branching and homo‐coupling) in thiophene‐based DArP is also elaborated. By emphasizing the principles behind monomer selection and catalytic system optimization, this review intends to provide a framework for future advancements in the DArP of thiophene‐containing CPs.
A potential posttranscriptional regulator for p60‐katanin: miR‐124‐3p
Authors: Kaya Yesim , Korulu Sirin , Tunoglu Ezgi Nurdan Yenilmez , Yildiz Aysegul 
Published: July 2023

AbstractKatanin is a microtubule severing protein belonging to the ATPase family and consists of two subunits; p60‐katanin synthesized by the KATNA1 gene and p80‐katanin synthesized by the KATNB1 gene. Microtubule severing is one of the mechanisms that allow the reorganization of microtubules depending on cellular needs. While this reorganization of microtubules is associated with mitosis in dividing cells, it primarily takes part in the formation of structures such as axons and dendrites in nondividing mature neurons. Therefore, it is extremely important in neuronal branching. p60 and p80 katanin subunits coexist in the cell. While p60‐katanin is responsible for cutting microtubules with its ATPase function, p80‐katanin is responsible for the regulation of p60‐katanin and its localization in the centrosome. Although katanin has vital functions in the cell, there are no known posttranscriptional regulators of it. MicroRNAs (miRNAs) are a group of small noncoding ribonucleotides that have been found to have important roles in regulating gene expression posttranscriptionally. Despite being important in gene regulation, so far no microRNA has been experimentally associated with katanin regulation. In this study, the effects of miR‐124‐3p, which we detected as a result of bioinformatics analysis to have the potential to bind to the p60 katanin mRNA, were investigated. For this aim, in this study, SH‐SY5Y neuroblastoma cells were transfected with pre‐miR‐124‐3p mimics and pre‐mir miRNA precursor as a negative control, and the effect of this transfection on p60‐katanin expression was measured at both RNA and protein levels by quantitative real‐time PCR (qRT‐PCR) and western blotting, respectively. The results of this study showed for the first time that miR‐124‐3p, which was predicted to bind p60‐katanin mRNA by bioinformatic analysis, may regulate the expression of the KATNA1 gene. The data obtained within the scope of this study will make important contributions in order to better understand the regulation of the expression of p60‐katanin which as well will have an incontrovertible impact on the understanding of the importance of cytoskeletal reorganization in both mitotic and postmitotic cells.
Ab Initio Molecular Dynamics Study of H2 Dissociation Mechanisms on Cu13 and Defective Graphene‐supported Cu13 Clusters: Active Sites, Energy Barriers and Adsorption States
Authors: Li Yueru , Wang Dunyou 
Published: July 2023

AbstractAb initio molecular dynamics calculations were performed to study H2 dissociation mechanisms on Cu13 and defective graphene‐supported Cu13 clusters. The study reveals that seven types of corresponding dissociation processes are found on the two clusters. The average dissociation energy barriers are 0.51 eV on the Cu13 cluster and 0.12 eV on the defective graphene‐supported Cu13 cluster, which are lowered by ~19 % and ~81 % compared with the pristine Cu(111) surface, respectively. Furthermore, compared with the pure Cu13 cluster, the average dissociation energy barrier on the defective graphene‐supported Cu13 cluster is substantially reduced by about 76 %. The preferred dissociation mechanisms on the two clusters are H2 located at a top‐bridge site with the barrier heights of 0.30 eV on the Cu13 cluster and −0.31 eV on the defective graphene‐supported Cu13 cluster. Analysis of the H−Cu bond interactions in the transition states shows that the antibonding‐orbital center shifts upward on the defective graphene‐supported Cu13 cluster compared with the one on the Cu13 cluster, which explains the reduction of the dissociation energy barrier. The average adsorption energy of dissociated H atoms is also greatly enhanced on the defective graphene‐supported Cu13 cluster, about twice that on the Cu13 cluster.
Microwave‐Assisted One‐Step Synthesis of 2′,3′‐Cyclic Phosphates of Nucleosides
Authors: Veena Kollery S. , Cruz Harold A. , Krishnamurthy Ramanarayanan 
Published: July 2023

Abstract2′,3′‐Cyclic canonical nucleotides are an important class of compounds playing broad roles in regulating biological processes and are investigated in the context of prebiotic chemistry as activated nucleotides for oligonucleotide formation. Despite their growing importance, synthetic access of 2′,3′‐cyclic nucleotides is constrained, resulting in their cost‐prohibitive commercial prices. Here, we describe a microwave‐assisted one‐pot synthesis starting from commercially available nucleosides employing an easily available cyclophosphorylating reagent, bis(dimethyldiamino)phosphorodiamidate (BDMDAP). The corresponding 2′,3′‐cyclic nucleotides are isolated in good yields (70‐91%) by a simple ion‐exchange column with no further workup. The nucleosides require no protecting group as the cyclophosphorylation reaction is selective for the 2′,3′‐dihydroxyl groups. The experimental protocol is robust and can be run in parallel to provide access to gram quantities of these 2′,3′‐cyclic nucleotides within a day. © 2023 The Authors. Current Protocols published by Wiley Periodicals LLC.Basic Protocol: Procedure for the phosphorylation of nucleoside (2′,3′‐cyclic phosphates of nucleosides)Support Protocol: Synthesis of bis(dimethylamino)phosphorodiamidate sodium salt
Power pool‐based supervisory coordinate control strategy for DC microgrids
Authors: Verma Shivpal R. , Ballal Makarand S. , Suryawanshi Hiralal M. , Deshmukh Rohit R. , Wakode Sarvesh A. 
Published: July 2023

SummaryStandalone DC microgrids are progressively becoming explored in the modern power system. Proper voltage regulation and effective power distribution among sources are the main challenges for DC microgrid operation. A supervisory coordinated control strategy for proportionate power‐sharing and enhanced voltage regulation is presented in this paper to overcome these challenges. The formation of multiple power pools on the basis of available power from each renewable energy source (RES) is a crucial element of this approach. It modifies the power sharing between power pools and individual sources based on the amount of power available in the sources. In addition, for effective power management, it coordinates the operation of all power pools with all RESs. Also, by reducing the charging and discharging cycle of energy storage systems (ESSs), it is possible to make effective use of ESSs. The proposed control adapts to intermittent RESs and changes in the microgrid network. The proposed method's capabilities are validated by experimental results.