bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of the influence of fatigue on the bending of Peltogyne sp.
Authors: Balanco Giovana Gobatto , Souza Clara Gaspar Fossi , Christoforo Andre Luis , Lahr Francisco Antonio Rocco 
Published: January 2023

Abstract
This work presents the fatigue analysis on Peltogyne sp.. The specimens were submitted to three-point bending tests during 300,000 cycles. Analysis of influence of the number of cycles on wood bending stiffness was performed by comparing MOE (longitudinal modulus of elasticity) measured every 100,000 cycles applied. At the end of the application of 300,000 cycles, a decrease in the MOE value of three specimens was observed in relation to the MOE measured at the beginning, without application of cycles. A fourth specimen showed an increase in the MOE value. The visual analysis of the specimens during the tests is also important since they showed cracks. Microscopic images were performed to support the analysis of the observed behavior. With the application of time and more stresses on the piece, the crack can increase to the point of generating rupture and collapse of the structure, so the cracks were a determining factor to confirm the suspicions regarding the weakening of the wood due to fatigue of the material.
Blood pressure variation in children with obesity and consumption of ultra-processed foods
Authors: Cortes Caroline , Brandão Joana Maia , Cunha Diana Barbosa , Paravidino Vitor Barreto , Sichieri Rosely 
Published: January 2023

Abstract
Objectives
Investigate the influence in UPF consumption, assessed through dietary and urinary markers, on systolic (SBP) and diastolic (DBP) blood pressure in children with obesity.
Methods
Longitudinal analysis from a randomized clinical trial carried out with children with obesity aged 7 to 12 years. For six months, children and guardians attended monthly individual consultations and educational activities to encourage a reduction in UPF consumption. Body weight, height, blood pressure, and 24-hour dietary recall were measured at all visits. Random urine samples were collected at baseline, at the second and fifth-month follow-up.
Results
A total of 96 children were included in the analysis. Energy, UPF intake and blood pressure showed a quadratic pattern change, with a decrease in the first two months and an increase thereafter. There was an association between the consumption of UPF and DBP. Intake of UPF was correlated to urinary Na/K ratio (r = 0.29; p = 0.008) and with dietary Na/K ratio (r = 0.40; p ≤ 0.001). For every 100g of increase in UPF, DBP increased by 0.28mmHg (p-value = 0.01) and with further adjustment for change in BMI, the increase was 0.22mmHg (p-value = 0.04).
Conclusions
Our findings indicated that UPF intake and not obesity had a greater contribution to the change in DBP, as an additional adjustment for BMI did not influence the results. Therefore, reducing UPF consumption can be a good preventive strategy against hypertensionin.
The effect and mechanism of POSTN and its alternative splicing on the apoptosis of myocardial cells in acute myocardial infarction
Authors: Liu Xuemei , Tuerxun Zulikaier , Balati Yumaierjiang , Gong Pengfei , Zhang Ze , Bao Zhen , Yang Yuchun , He Pengyi , Muhuyati Muhuyati 
Published: January 2023

Abstract
Background
Acute myocardial infarction (AMI) is characterized by high morbidity and mortality, and has no effective treatments. Our study aimed to investigate key molecular targets in the pathogenesis of AMI, and provide new strategy for the treatment.
Methods
The myocardial ischemia and hypoxia model was constructed by using cardiomyocytes from HL-1 mice. The constructed cardiomyocytes, along with normal cardiomyocyte controls, were transfected with lentiviruses carrying over-expressed POSTN gene (GV492-POSTN-WT), over-expressed POSTN alternative splicing gene (GV492-POSTN-MUT) and negative control (GV492-NC), respectively. Cardiomyocyte proliferation and apoptosis, and the level of proteins related to endoplasmic reticulum stress and apoptosis was examined to explore the effects and mechanisms of POSTN and its alternative splicing on the proliferation and apoptosis of ischemic hypoxic and normal cardiomyocytes.
Results
Ischemic hypoxic and normal cardiomyocytes transfected with GV492-POSTN-WT showed significantly increased OD value, and significantly decreased apoptosis (p < 0.05), with low expression of elF2α, CHOP, GRP78, ATF4 and BAX and high expression of BCL-2 (p < 0.05). Cardiomyocytes transfected with GV492-POSTN-MUT also showed significantly decreased apoptosis (p < 0.05), however, the expression levels of elF2α, CHOP, GRP78, ATF4, BAX and BCL-2 showed no difference between the 2 groups.
Conclusion
POSTN could promote the proliferation whilst inhibit the apoptosis of normal and ischemic hypoxic cardiomyocytes. The mechanism by which POSTN inhibits cardiomyocyte apoptosis may be through inhibiting the GRP78-eIF2α-ATF4-CHOP pathway of endoplasmic reticulum stress. The alternative splicing of POSTN could also inhibit cardiomyocyte apoptosis, however the mechanism requires further investigation. Our results demonstrated that POSTN might be a potential therapeutic target for AMI.
Dosimetric and radiobiological comparison of IMRT, VMAT, and Helical tomotherapy planning techniques in hippocampal sparing whole brain radiotherapy with simultaneous integrated boost for multiple brain metastases
Authors: Balasubramanian S , Shobana M K , Anabalagan D , Thanasekar P , Joel S , Chaudhary Prekshi 
Published: January 2023

Abstract
Purpose
To compare treatment planning and dosimetric outcomes for hippocampal sparing whole brain radiotherapy (WBRT) with the simultaneous integrated boost (SIB) in brain metastasis (BM) patients using tumour control probability (TCP) and normal tissue complication probability (NTCP) formalism between IMRT, VMAT, and HT techniques.
Methods and Materials
In this retrospective study, the treatment data of 20 BM patients who typically received whole brain radiation with SIB treatment were used. Prescription doses of 30Gy and 36Gy was delivered in 10 fractions for WBRT and SIB, respectively. Niemierko and LKB models were applied for calculating TCP and NTCP.
Results
All the plans were evaluated for the RTOG 0933 protocol criteria and found acceptable. Additionally, the homogeneity of the PTV boost is 0.07 ±0.01,0.1 ±0.04, and 0.08 ±0.02 for IMRT, VMAT, and HT, respectively (P<0.05). The percentage of TCP for the PTV boost was 99.99±0.003, 99.98 ±0.004, and 99.99±0.002 of IMRT, VMAT, and HT, respectively, (P<0.005). The NTCP value of the lenses was higher with the VMAT plan as compared to IMRT and HT Plans. The hippocampal NTCP values are equal in all three planning proficiencies.
Conclusion
The techniques like IMRT, VMAT, and HT can reduce the dose received by hippocampus to the dosimetric threshold during the delivery of WBRT with hippocampal sparing and can simultaneously boost multiple metastases. Overall, the high-quality dose distribution, TCP, and NTCP comparison between all three planning techniques show that the HT technique has better results when compared to the VMAT and IMRT techniques.
Eco-efficiency of the Transportation Process in the Context of Reducing Greenhouse Gas Emissions
Authors: ŚLASKI Paweł 
Published: January 2023

Abstract
Global warming is one of the most common issues in the context of climate change and means a constant increase in the average air temperature on Earth. The main cause of changes affecting the natural environment is human activity. There may also exist a positive feedback loop between phenomena such as: melting of natural ice-lands and glaciers, rising water levels in seas and oceans, increased frequency of extreme weather events (heat waves, violent storms, hurricanes, droughts, floods and fires) climatic phenomena. These phenomena have massive socio-economic consequences, e.g. high costs of managing losses caused by weather phenomena, or increased spending on adaptation measures. The most important task is to reduce greenhouse gas emissions into the atmosphere, and one of the most important elements is the change in the direction of energy policy - the transition from traditional fossil fuels towards zero-emission energy sources, and according to the author of the publication, systemic changes in the transport process are also necessary. The article proposes a mathematical model of the eco-efficiency of the transportation process in terms of reducing CO2 emissions to the natural environment. A detailed analysis of the delivery costs was carried out, which in turn led to measurable model results in the form of optimal parameters of the tested process (frequency of deliveries and economic volumes of deliveries) at minimal costs.
Preimplantation genetic testing for aneuploidy could not improve cumulative live birth rate among 1,003 couples with recurrent pregnancy loss
Authors: Zhao Shaotong , Lyu Chunzi , Huang Yumei , Liu Yingbo , Zhang Qian , Ni Tianxiang , Yan Junhao 
Published: January 2023

Abstract
Background
PGT-A has been widely used for RPL couples to help improve pregnancy outcomes by selecting euploid embryos. However, there is still insufficient evidence to determine the effectiveness of PGT-A in RPL couples, especially on the cumulative live birth rate. This study aims to investigate whether preimplantation genetic testing for aneuploidy (PGT-A) could improve the cumulative live birth rate in patients with recurrent pregnancy loss (RPL).
Methods
A retrospective large cohort study with 1003 RPL couples (799 in the PGT-A group, and 204 in the conventional IVF/ICSI group) was conducted in a university-affiliated reproductive center. Stratified analysis was performed according to female age (< 35 years and ≥ 35 years). The associations between embryo selection with PGT-A and cumulative pregnancy outcomes were further analyzed by a binary logistic regression model.
Results
The cumulative live birth rates were similar between the PGT-A group and the conventional IVF/ICSI group both in women under 35 years old [53.32% vs. 61.97%, adjusted OR (95%CI): 0.853(0.547–1.330), P = 0.483] and in women aged ≥ 35 years [28.75% vs. 30.65%, adjusted OR (95%CI): 1.314(0.671–2.574), P = 0.426]. Whereas, a significantly lower cumulative rates of biochemical pregnancy loss (10.13% vs. 32.56%, P < 0.05) and clinical pregnancy loss [20.89% vs. 37.21%, adjusted OR (95%CI): 0.408(0.173–0.966), P = 0.042] were found in the PGT-A group compared with the control group, only among women aged ≥ 35 years. The numbers of embryo transfers were significant less in PGT-A women with < 35 years old [1(1;2) vs. 1(1;2), P < 0.05] and with ≥ 35 years old [1(1;1) vs. 1(1;2), P < 0.05].
Conclusions
PGT-A could not improve cumulative live birth rate in RPL couples regardless maternal age.
Design of automotive mechanical automatic transmission system based on torsional vibration reduction
Authors: You Zhuan 
Published: January 2023

Automatic transmission system is the core part of vehicle transmission processing, which can improve driving safety. In order to improve the shift effect of automotive automatic mechanical transmission and narrow the gap between the vehicle speed and the expected speed, an automotive automatic mechanical transmission system based on torsional damping was designed in the experiment. On the basis of hardware composed of different modules and fuzzy control algorithm, the system realizes the software design of vehicle automatic mechanical transmission system. The experimental results show that when the system is applied in practice, the gear selection time of the vehicle is between 0.2 s-0.3 s, and the gear shift time is between 0.3 s-0.4 s. The gap between the vehicle speed and the expected speed, and between the vehicle speed and the expected speed is small. The practical application effect is good.
Experimental evaluation of two-layer air bubble curtains to prevent seawater intrusion into rivers
Authors: Kahrizi Ehsan , Salehi Neyshabouri Seyed Ali Akbar , Zeynolabedin Amin , Souri Javad , Akbari Hassan 
Published: January 2023

Abstract
The seawater intrusion (SWI) into rivers can lead to many negative consequences, especially on agricultural activities and live ecosystems in upstream areas of rivers. One solution to prevent SWI is using air bubble curtains (ABCs). The objective of this study is to investigate the optimal location of ABCs and airflows. To this end, several tests with different flow and salinity rates were performed and effect of ABC location on SWI investigated. The results show that, when the ratio of seawater to freshwater densities increased from 1.006 to 1.010, the ratio of saline wedge tip velocity to seawater velocity, airflow to seawater discharge ratio for first and second ABCs are raised 60, 58, and 70%, respectively. Also, when the Froude number (Fr) &gt; 0.031, seawater density changes do not significantly affect the process of SWI. Besides, results of the study show that the closer the ABC is to the river downstream, the higher the airflow rates required. In addition, the optimal value of air bubbles for controlling SWI depends on the density of seawater, where more airflow is required to control denser flows. Finally, the regression equations to predict the SWI parameters based on flow properties were derived.
Identification of Kaempferol as Viral Entry Inhibitor and DL-Arginine as
Viral Replication Inhibitor from Selected Plants of Indian Traditional
Medicine against COVID-19: An in silico Guided in vitro Approach
Authors: Jayaprakashkamath Adithya , Murali Maneesha , Nair Bhagyalakshmi , Benny Feby , Mani Rajalakshmi P. , Suresh Darsana , Presanna Aneesh T. , Areekkara Amrutha N. , Nath Lekshmi R. 
Published: January 2023

Background:
Indian traditional medicinal plants are known for their great potential in
combating viral diseases. Previously, we reported a systematic review approach of seven plausible
traditional Indian medicinal plants against SARS-CoV-2.

Methods:
Molecular docking was conducted with Biovia Discovery Studio. Three binding domains
for spike glycoprotein (PDB IDs: 6LZG, 6M17, 6M0J) and one binding domain of RdRp
(PDB ID: 7BTF) were used. Among 100 phytoconstituents listed from seven plants by the IMPPAT
database used for virtual screening, the best six compounds were again filtered using Swiss
ADME prediction and Lipinski's rule. Additionally, a pseudovirion assay was performed to study
the interaction of SARS-CoV-2 S1-protein with the ACE 2 receptor to further confirm the effect.

Results:
Chebulagic acid (52.06 Kcal/mol) and kaempferol (48.84 Kcal/mol) showed increased
interaction energy compared to umifenovir (33.68 Kcal/mol) for the 6LZG binding domain of
spike glycoprotein. Epicatechin gallate (36.95 Kcal/mol) and arachidic acid (26.09 Kcal/mol)
showed equally comparable interaction energy compared to umifenovir (38.20 Kcal/mol) for the
6M17 binding domain of spike glycoprotein. Trihydroxychalcone (35.23 Kcal/mol) and
kaempferol (36.96 Kcal/mol) showed equally comparable interaction energy with umifenovir
(36.60 Kcal/mol) for 6M0J binding domain of spike glycoprotein. Upon analyzing the phytoconstituents
against RdRp binding domain, DL-arginine (41.78 Kcal/mol) showed comparable results
with the positive control remdesivir (47.61 Kcal/mol). ADME analysis performed using Swiss
ADME revealed that kaempferol and DL arginine showed drug-like properties with appropriate
pharmacokinetic parameters. Further in vitro analysis of kaempferol by pseudovirion assay confirmed
an acceptable decrease of the lentiviral particles in transfected HEK293T-hACE2 cells.

Conclusion:
The study highlights that kaempferol and DL-arginine could be the significant molecules
to exhibit potent action against SARS-CoV-2 and its variants.
Protective Effects of Momordica charantia (Bitter Melon) against Methotrexate-
induced Kidney Damage
Authors: Macit Caglar , Ozbeyli Dilek , Cevik Ozge , Cetin Melisa , Sener Goksel , Özkan Sevil 
Published: January 2023

Background:
Methotrexate is a cytotoxic chemotherapeutic agent that has severe side effects,
such as nephrotoxicity. Momordica charantia is a bright yellow-orange fruity plant that has been
shown to have antioxidant, antidiabetic, and anti-inflammatory properties.

Objective:
This study scrutinized the protective effects of Momordica charantia extract against methotrexate-
induced nephrotoxicity.

Methods:
24 Sprague Dawley male rats were divided into three experimental groups (8 rats in each):
Control (C); Methotrexate (MTX); and Methotrexate plus Momordica charantia (MTX+MC). All rats
were fed ad libitum and tap water. Methotrexate was administered at 20 mg/kg intraperitoneally as a
single dose. In the MTX+MC group, MC was administered at a dose of 50mg/kg for 5 days orally. At
the end of the 5th day, the rats were decapitated and kidney samples were taken to analyze glutathione
(GSH), malondialdehyde (MDA), myeloperoxidase (MPO), 8-hydroxy-2'-deoxyguanosine (8-OHdG)
and caspase-3 activity. Data was analyzed with GraphPad Prism 5.0.

Results:
Findings showed that while there was a significant increase in MDA, MPO, 8-OHdG levels,
and an essential reduction in GSH levels in the MTX-treated group when compared with the control
group, bitter melon treatment significantly reversed MDA, MPO, and 8-OHdG levels (p< 0.001). GSH
level elevation was observed in the MTX-MC group when compared to the MTX-treated group (p<
0.001).

Conclusion:
This study showed that bitter melon is thought to have a protective effect against kidney
damage caused by methotrexate. With future studies, we believe that the use of bitter melon extract as
a protective agent in kidney damage caused by drug-induced oxidative damage will bring an innovative
approach to treatment.
Advances in the Treatment of Chronic Myeloid Leukemia
Authors: Mihăilă Romeo G. 
Published: January 2023

Background:
The treatment of chronic myeloid leukemia has progressed in recent decades, becoming a model for a disease whose pathogenesis is primarily based on a genetic mutation and has led to survivals comparable to those of the general population.

Objective:
This review aims to present recent therapeutic advances in this area.

Methods:
A mini-review was achieved using the articles published in Web of Science and Pub-
Med between January 2021 - May 2022, and new patents were made in this field.

Results:
The three generations of tyrosine kinase inhibitors have transformed chronic myeloid
leukemia into a manageable disorder and greatly improved the treatment results of the chronic
phase, the prognosis, survival, and quality of life of patients. The therapeutic goals today include
achieving a deep and lasting molecular response as soon as possible, successful treatment-free remission,
and discovering and applying new therapeutic strategies to act on impaired immune
modulation and dormant leukemic stem cells. The allosteric inhibitor asciminib targets the ABL
myristoyl pocket, reduces Abl kinase activity, and is effective against most cells that have mutations
in the ABL1 kinase domain. Progress and recommendations for achieving long-term treatment-
free remission are set out. Nearly 50% of the patients who received first-line tyrosine kinase
inhibitors required a change of treatment by 10 years due to intolerance or resistance to treatment.
Their main side effects are presented.

Conclusion:
Obtaining a deep and persistent molecular response contributes to achieving longterm
treatment-free remission.
Motorcycle Accident and Associated Factors among Commercial Motorcycle Drivers in Kindo Koyisha Woreda, Southern Ethiopia
Authors: Raga Abdi , Asres Abiyot Wolie , Samuel Serawit , Addisu Tigabu , Abreha Solomon 
Published: January 2023

Background
Motorcycle accidents are a prominent cause of disability and death, particularly in low- and middle-income countries. Therefore, the aim of this study was to describe the magnitude of motorcycle accidents and associated factors among commercial motorcycle drivers.

Methods
A community-based cross-sectional study design was conducted among 235 motorcycle drivers from April 1 to 22, 2021. The participants were selected using a simple random sampling method. A pretested, structured questionnaire was used to collect the data. The data was entered into Epi Info and exported to SPSS version 20 for analysis. Descriptive and association measures were done. The results were presented within texts and tables.

Results and Discussion
The magnitude of motorcycle accidents among commercial motorcycle drivers was 65.1% (95% CI: 59%, 71.2%). Driving at speeds greater than 60 km/h (AOR = 8.19, 95% CI: 4.02, 11.42), driving at all hours of the day and night (AOR = 4.05, 95% CI: 1.61, 9.02), using a mobile phone while driving (AOR = 4.42, 95% CI: 2.73, 7.15), having a history of punishment (AOR = 11.05, 95% CI: 8.54, 16.28), drinking alcohol (AOR = 2.3, 95% CI: 1.3, 5.14), being under 20 years old (AOR = 1.78, 95% CI: 1.56, 5.23), and having a license (AOR = 0.24, 95% CI:0.1, 0.8) were factors associated with commercial motorcycle accidents.

Conclusion
This finding indicated the need for continuous awareness creation and intense training, along with checking the licenses for their originality. Such a pluralistic overview can also denote the roles of proper operation and technical readiness of the motorcycles running, the proper design of urban mobility and road (cross-roads) construction, as well as the central governmental measures and policies that can act proactively to prevent such accidents from occurring.
Aspergilloma: Clinical Manifestation After Tuberculosis Infection
Authors: Winarni Tika Wahyu , Erawati Dini Rachma 
Published: January 2023

Aspergilloma is a mass-like fungus ball consisting of Aspergillus fumigatus. Aspergilloma occurs in patients with pulmonary structural abnormalities in which the presence of a previous cavity is the predisposing factor that most often results in Aspergillus colonization, especially in tuberculosis endemic countries. 28 y.o andÂ 33 y.o female , complained of hemoptysis, chest pain, weight loss, and a history of TB treatment. The chest X-ray and CT scan revealed a solid lesion with an â€œAir-crescent signâ€ indicating Aspergilloma lesion. Patients were given symptomatic, anti-fungal drugs, and supportedÂ by embolization procedure to reduce hemoptysis. The patient's condition began to improve after treatment. Imaging findings in x-rays and CT scans that point to Aspergilloma will help doctors in further management to provide a better prognosis for the patient.
Picture Archiving and Communication Systems (PACS) as a Solution to Inequality in the Number of Radiological Resources in West Java
Authors: Barasabha Thareq , Hardiyanti Yati 
Published: January 2023

Inequality of health care facilities, especially radiology resources, occurs in West Java Province. There are many class A hospitals in provincial capitals, while in areas far from the provincial capital and from DKI Jakarta Province, the quantity and quality of hospitals are still lacking. Likewise with the quantity of radio diagnostic instruments and human resources. 12 radiology specialists and an additional 192 radiographers are needed in West Java Province. Archiving and image communication systems (PACS) can be used as a solution so that health workers in hospitals located far from the city or district centers can consult, and expert conclusions can be obtained from radiology specialists at referral centers.
Keywords: PACS, radio diagnostic, radiology specialist, radiographer, West Java