bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cinephilia, Publics, Cinegoraphilia: Surveying the Short-Term Effects of Covid-19 on Community-Based Festivals in Toronto
Authors: Petrychyn Jonathan 
Published: January 2023

AbstractThis chapter documents and theorizes community-based film festival programming and organizing tactics during the first wave of the Covid-19 pandemic between March and September 2020. Drawing from autoethnographic experience and personal conversations with organizers of the Toronto Queer Film Festival (TQFF) and Toronto Outdoor Picture Show (TOPS), I offer the neologism “cinegoraphilia”—a portmanteau of cinephilia and the Ancient Greek agora—to theorize both festival’s strategies to capture the love of watching cinema in public together. As a theory that centers the communal, public features of cinemagoing, cinegoraphilia orients us toward the ways community-based film festivals creatively tried to retain and engage their audiences. I situate TOPS’s and TQFF’s efforts to capture cinegoraphilia within the broader context of public health restrictions in the Canadian province of Ontario, as well as changes to the arts funding ecosystem and funding policy locally in Toronto, provincially in Ontario, and nationally across Canada.
Film Festivals in Taiwan: Lurking on the Periphery
Authors: Tsai Beth 
Published: January 2023

AbstractThis chapter investigates an ongoing geopolitical shift concerning the status of festivals in Taiwan—exemplified by the Taipei Film Festival and the Taipei Golden Horse Film Festival and Awards—and their future challenges instigated by the global pandemic. I consider film festivals in Taiwan to be lurking on the “periphery” and argue they should not be prescribed as secondary and unnoticed (in terms of prestige and influences). Instead, we need to identify the center (Western Europe and wealthy North America) versus the periphery paradigm in which the global festival circuit continued to reinforce power relations where mid- or lower-ranking film festivals had to wrestle with the hierarchy of status. This chapter begins by tracing how the pandemic preparedness in Taiwan allowed most Taiwanese film festivals to conduct business as usual. Yet this local advantage—abetted by the country’s history and political dissension with the People’s Republic of China (PRC)—is impeded by the collateral implications from disrupted festivals worldwide. The impacts of Covid-19 continue to further expose the unequal power relations within the globalized festival network, despite the survival and strife for the success of mid-level and regional film festivals.
Precarity, Innovation, and Survival in the Indian Film Festival Sector
Authors: Karlekar Tilottama 
Published: January 2023

AbstractDespite the vast expansion in the film festival sector in India since the early 2000s, most festivals have remained financially precarious. This is true of more mainstream festivals with industry support as well as of myriad activist and “alternative” festivals on the margins. In addition, the country’s Hindu nationalist government has subjected all cultural spaces to increased scrutiny and policing. As the virus affected India and the Indian government enforced a national lockdown, festival organizers had to adapt rapidly. In order to survive, they looked both to global strategies and specific local histories of exhibition and circulation. In this chapter, I map the festival sector in India in the midst of crisis and explore the divergent strategies for survival adopted by festival organizers. I focus closely on the “frontline” strategies implemented by two community-based, activist film festivals that have adopted distinct, yet successful, models for navigating the pandemic. Already adept at negotiating multiple forms of precarity, they connected with new global audiences while redefining ideals of “community.” This chapter explores what these festival experiments tell us about how the festival as medium might change politically, economically, and cinematically, even beyond the pandemic.
Curating as Care: La Semaine de la Critique and the Marrakech International Film Festival in the Age of Covid-19
Authors: Dramani-Issifou Farah Clémentine 
Published: January 2023

AbstractThe health crisis caused by Covid-19 has changed the organization of film festivals around the world. Some festivals have chosen to maintain their event by creating online platforms for the distribution of films and professional meetings; others have simply canceled their physical editions. Although they were canceled, Cannes Critics’ Week and the Marrakech International Film Festival made specific arrangements to support the local, regional, and international film industry. The pandemic fundamentally impacted festivals’ programming strategies. As such, Covid-19 redefined the work of selection committees: it created what I call “flexi-programmers.” What strategies have been adopted by Cannes Critics’ Week and Marrakech International Film Festival to deal with this crisis? How could film curating be the future of film programming?
Locating Buzz and Liveness: The Role of Geoblocking and Co-presence in Virtual Film Festivals
Authors: Burgess Diane , Stevens Kirsten 
Published: January 2023

AbstractThe sudden and near-complete move of festivals into the online space in 2020 complicated our understanding of the “there” and “then” involved in film festival participation. Experiencing festivals in lockdown (often from domestic spaces), “taking part” in these virtual events had the potential to dramatically expand the points of access. Although this approach was taken early with the YouTube-based We Are One global film festival, for the vast majority of single-festival-run online events access was limited to specific geographic areas through geoblocking technology. This chapter examines the function of geofenced access in virtual and hybrid virtual/real-world film festivals. It poses the question: what are the benefits for festivals in enforcing territoriality and place-boundedness in the de-territorialized world of online media? Looking to the importance of embodied co-presence and networked publics in existing understandings of liveness, buzz, and value creation at festivals, we interrogate the role of “place” in defining festival prestige and influence. We ask, if the mechanisms of value creation linked to the physical spectacle and viral spread of buzz at festivals are disrupted, will the film festival experience still be seen as valuable? And what might that mean for the future of festivals and their study?
Film Festivals on the Small Screen: Audiences, Domestic Space, and Everyday Media
Authors: Vail James , Heath Theresa , Dickson Lesley-Ann , Finkel Rebecca 
Published: January 2023

AbstractSince March 2020 in the UK, film festivals have moved to a variety of broadcast, video-on-demand (VOD), and VOD-like forms of film exhibition. Film viewing takes place on home television sets, laptops, and mobile devices and, due to the often-flexible form of film scheduling, the film festival comes to sit within and against the rhythms of everyday media use. This chapter provides a conceptual framework to theorize film festival audiences in this context. We argue that any account of online film festival audiences should take into consideration the relationship between film festival viewing and other media practices. Specifically, we draw attention to the ways in which film festival viewing practices are framed as distinct from other domestic media practices in the context of everyday life. We outline three main “sites” in which this framing occurs. The first site relates to the spaces of media consumption. The second relates to the temporal rhythms of media use. The third encompasses the forms of social interaction between different audience members. We argue that it is within these three sites that the frame of the online film festival is performed, negotiated, or felt to be missing.
Chilean Film Festivals and Local Audiences: Going Online?
Authors: Peirano María Paz , Ramírez Gonzalo 
Published: January 2023

AbstractThis chapter reviews the impact of the global pandemic of Covid-19 on Chilean film festivals and how this affected their relationship with local audiences. Chilean festivals are small events that exist under precarious conditions, facing different economic and cultural challenges that complicate their stability. After the Chilean estallido (a social outburst in 2019), the current health crisis has further affected their position, due to their cancelation and/or postponement, and most of them have temporarily transformed into online events to ensure their survival. We provide an overview on how Covid-19 has affected festivals in Chile as well as their responses to this crisis, which we understand within a particular context that has been pressuring onsite exhibitions and collective viewing. We mapped and tracked the festivals’ activities throughout 2020 and 2021 and used online ethnographic methods to observe some cases more closely, conducting participant observation of online activities and interviewing festival organizers. As such, the chapter addresses some of the new ways in which film festivals developed to engage with their audiences during the pandemic. We conclude with an emphasis on festivals’ responses as adaptive strategies and poses some questions on the future developments of these events.
The impact of single nucleotide polymorphisms on return-to-work after taxane-based chemotherapy in breast cancer
Authors: Hjorth Cathrine F. , Damkier Per , Stage Tore B. , Feddersen Søren , Hamilton-Dutoit Stephen , Ejlertsen Bent , Lash Timothy L. , Bøggild Henrik , Sørensen Henrik T. , Cronin-Fenton Deirdre 
Published: January 2023

Abstract
Purpose
Breast cancer treatment is associated with adverse effects, which may delay return-to-work. Single nucleotide polymorphisms (SNPs) may influence the risk and severity of treatment toxicities, which in turn could delay return-to-work. We examined the association of 26 SNPs with return-to-work in premenopausal women with breast cancer.

Methods
Using Danish registries, we identified premenopausal women diagnosed with non-distant metastatic breast cancer during 2007‒2011, assigned adjuvant combination chemotherapy including cyclophosphamide and docetaxel. We genotyped 26 SNPs in 20 genes (ABCB1, ABCC2, ABCG2, CYP1A1, CYP1B1, CYP3A, CYP3A4, CYP3A5, GSTP1, SLCO1B1, SLCO1B3, ARHGEF10, EPHA4, EPHA5, EPHA6, EPHA8, ERCC1, ERCC2, FGD4 and TRPV1) using TaqMan assays. We computed the cumulative incidence of return-to-work (defined as 4 consecutive weeks of work) up to 10 years after surgery, treating death and retirement as competing events and fitted cause-specific Cox regression models to estimate crude hazard ratios (HRs) and 95% confidence intervals (CIs) of return-to-work. We also examined stable labor market attachment (defined as 12 consecutive weeks of work).

Results
We included 1,964 women. No associations were found for 25 SNPs. The cumulative incidence of return-to-work varied by CYP3A5 rs776746 genotype. From 6 months to 10 years after surgery, return-to-work increased from 25 to 94% in wildtypes (n = 1600), from 17 to 94% in heterozygotes (n = 249), and from 7 to 82% in homozygotes (n = 15). The HR showed delayed return-to-work in CYP3A5 rs776746 homozygotes throughout follow-up (0.48, 95% CI 0.26, 0.86), compared with wildtypes. Estimates were similar for stable labor market attachment.

Conclusion
Overall, the SNPs examined in the study did not influence return-to-work or stable labor market attachment after breast cancer in premenopausal women. Our findings did suggest that the outcomes were delayed in homozygote carriers of CYP3A5 rs776746, though the number of homozygotes was low.
Single-cell high-dimensional imaging mass cytometry: one step beyond in oncology
Authors: Glasson Yaël , Chépeaux Laure-Agnès , Dumé Anne-Sophie , Lafont Virginie , Faget Julien , Bonnefoy Nathalie , Michaud Henri-Alexandre 
Published: January 2023

Abstract
Solid tumors have a dynamic ecosystem in which malignant and non-malignant (endothelial, stromal, and immune) cell types constantly interact. Importantly, the abundance, localization, and functional orientation of each cell component within the tumor microenvironment vary significantly over time and in response to treatment. Such intratumoral heterogeneity influences the tumor course and its sensitivity to treatments. Recently, high-dimensional imaging mass cytometry (IMC) has been developed to explore the tumor ecosystem at the single-cell level. In the last years, several studies demonstrated that IMC is a powerful tool to decipher the tumor complexity. In this review, we summarize the potential of this technology and how it may be useful for cancer research (from preclinical to clinical studies).
Proteomics to study cancer immunity and improve treatment
Authors: Franciosa Giulia , Kverneland Anders H. , Jensen Agnete W. P. , Donia Marco , Olsen Jesper V. 
Published: January 2023

AbstractCancer survival and progression depend on the ability of tumor cells to avoid immune recognition. Advances in the understanding of cancer immunity and tumor immune escape mechanisms enabled the development of immunotherapeutic approaches. In patients with otherwise incurable metastatic cancers, immunotherapy resulted in unprecedented response rates with the potential for durable complete responses. However, primary and acquired resistance mechanisms limit the efficacy of immunotherapy. Further therapeutic advances require a deeper understanding of the interplay between immune cells and tumors. Most high-throughput studies within the past decade focused on an omics characterization at DNA and RNA level. However, proteins are the molecular effectors of genomic information; therefore, the study of proteins provides deeper understanding of cellular functions. Recent advances in mass spectrometry (MS)-based proteomics at a system-wide scale may allow translational and clinical discoveries by enabling the analysis of understudied post-translational modifications, subcellular protein localization, cell signaling, and protein–protein interactions. In this review, we discuss the potential contribution of MS-based proteomics to preclinical and clinical research findings in the context of tumor immunity and cancer immunotherapies.
Undecidable Translational Tilings with Only Two Tiles, or One Nonabelian Tile
Authors: Greenfeld Rachel , Tao Terence 
Published: January 2023

AbstractWe construct an example of a group$$G = \mathbb {Z}^2 \times G_0$$G=Z2×G0for a finite abelian group $$G_0$$G0, a subsetEof $$G_0$$G0, and two finite subsets$$F_1,F_2$$F1,F2of G, such that it is undecidable in ZFC whether$$\mathbb {Z}^2\times E$$Z2×Ecan be tiled by translations of$$F_1,F_2$$F1,F2. In particular, this implies that this tiling problem isaperiodic, in the sense that (in the standard universe of ZFC) there exist translational tilings ofEby the tiles$$F_1,F_2$$F1,F2, but no periodic tilings. Previously, such aperiodic or undecidable translational tilings were only constructed for sets of eleven or more tiles (mostly in $$\mathbb {Z}^2$$Z2). A similar construction also applies for$$G=\mathbb {Z}^d$$G=Zdfor sufficiently large d. If one allows the group$$G_0$$G0to be non-abelian, a variant of the construction produces an undecidable translational tiling with only one tile F. The argument proceeds by first observing that a single tiling equation is able to encode an arbitrary system of tiling equations, which in turn can encode an arbitrary system of certain functional equations once one has two or more tiles. In particular, one can use two tiles to encode tiling problems for an arbitrary number of tiles.
Zwischen Bagatellisierung und Pathologisierung: Gesundheitsversorgung im Alter und die Zeitstruktur guten Lebens
Authors: Schweda Mark , Hummers Eva , Kleinert Evelyn 
Published: January 2023

ZusammenfassungSteigende Lebenserwartung, sozialer Wandel und medizinische Innovationen fordern traditionelle Sichtweisen auf das Alter(n) heraus. Was einst als eine „normale“ Alterserscheinung galt, wird heute im Lichte veränderter Lebensentwürfe und neuartiger Interventionsmöglichkeiten oft schon als Erkrankung aufgefasst und behandelt. Altersbezogene Gesundheitsstandards und Behandlungsziele geraten in Bewegung. Es eröffnet sich ein Spannungsfeld zwischen Bagatellisierung und Pathologisierung von Alterungsprozessen, das der ethischen Reflexion bedarf. Der Beitrag geht der Frage nach, wie individuelle und gesellschaftliche Vorstellungen des Alter(n)s im Kontext der modernen Medizin ethisch zu verstehen sind. Dazu geben wir zunächst einen Überblick zur Rolle von Altersbildern in der medizinischen und pflegerischen Versorgung älterer Menschen. Anschließend werden begrifflich-theoretische Perspektiven umrissen, die solche Bilder des Alter(n)s einer strebensethischen Analyse zugänglich machen. Welche Formen der Gesundheitsversorgung im höheren Alter als sinnvoll und angemessen zu gelten haben, ist demnach nicht zuletzt im Licht der Frage nach der Zeitstruktur guten Lebens zu diskutieren.
Creutzfeldt-Jakob-Krankheit – eine mögliche Differentialdiagnose an einer Psychiatrie
Authors: Wimmer Romana , Steiner Milena , Matz Karl , Stöger Peter 
Published: January 2023

ZusammenfassungPrionenerkrankungen sind letale neurodegenerative Erkrankungen, die durch eine Konformationsänderung des physiologischen Prionproteins in eine pathologische Variante ausgelöst werden. Dieses physiologische Prionprotein lagert sich in den Nervenzellen ab, wodurch es zum Zelltod kommt. Von der sporadisch auftretenden Variante der Creutzfeldt-Jakob-Krankheit (CJK), die 90 % der Fälle ausmacht, gibt es in Österreich 14–18 Fälle pro Jahr. Die häufigste Form der sporadischen CJK geht mit den klassischen Symptomen einer raschen dementiellen Entwicklung, einer kortikalen Sehstörung und Myoklonien einher. Je nach neurologischer Verteilung der neuropathologischen Veränderungen können auch andere Symptome im Vordergrund stehen, wie zum Beispiel Schlafstörungen, Ataxie, Pyramidenbahnzeichen oder epileptische Anfälle.Bei der MV2K-Untervariante der CJK, die in 10 % der sporadischen Fälle vorkommt, also 1,4–1,8 Mal im Jahr in Österreich, steht allerdings die psychiatrische Symptomatik im Vordergrund. Eine Patientin mit ebendieser Variante und unklarer, neu aufgetretener, psychiatrischer Symptomatik wurde an unserer psychiatrischen Abteilung aufgenommen und erhielt während ihres stationären psychiatrischen Aufenthalts, in enger Zusammenarbeit mit der Neurologie, erstmals die Diagnose CJK. Ein Wissen um die möglichen psychiatrischen und neurologischen Symptome ist also auch für Psychiater*innen von Bedeutung.
Optimization of the regioselective synthesis of mixed cellulose 3,5-dimethylphenyl and α-phenylethyl carbamate selectors as separation phases for chiral HPLC
Authors: Bui Cuong Viet , Rosenau Thomas , Hettegger Hubert 
Published: January 2023

AbstractRegioselective tritylation and carbonate aminolysis were employed in this work to synthesize cellulose 2,3-bis(3,5-dimethylphenyl carbamate)-6-(α-phenylethyl carbamate)-type chiral selectors. We evaluated and optimized the critical aspects of regioselective tritylation and detritylation at C6 of the glucopyranose units of the polysaccharide backbone. The advantage of using cellulose II in comparison to cellulose I for tritylation was analyzed and the detritylation time was determined by a fast and simple thin-layer chromatography method. Optimization of both tritylation and detritylation was accompanied by a combination of analytical techniques. Oxycarbonylation with phenyl chloroformate was used to introduce a reactive phenyl carbonate moiety at C6 of the intermediate cellulose 2,3-bis(3,5-dimethylphenyl carbamate), which was subsequently converted to the respective cellulose 6-(α-phenylethyl carbamate) derivative by aminolysis with enantiopure (R)- or (S)-α-phenylethylamine. The starting material, intermediates, and target cellulose derivatives were comprehensively analytically characterized by ATR-FTIR, solid- and liquid-state13C NMR, GPC, and elemental analysis. With the optimized protocol, it became possible to obtain cellulose carbamate-type chiral selectors through carbonate aminolysis with simple and commercially available primary amines instead of reaction with isocyanate reagents. The enantioseparation performance of the obtained chiral selectors was evaluated against cellulosetris(3,5-dimethylphenyl carbamate) as a reference selector with a selection of chiral analytes.Graphical abstract
The relation between attitudes towards mathematics and dropout from university mathematics—the mediating role of satisfaction and achievement
Authors: Geisler Sebastian , Rach Stefanie , Rolka Katrin 
Published: January 2023

AbstractThe transition from school to university mathematics is a challenging process for many students, which is reflected in high dropout rates during the first year at university. Using mediation analysis, we want to shed light on the role of students’ attitudes towards mathematics—especially their interest in mathematics and their mathematical self-concept—for early dropout and investigate the underlying mechanisms for the relations between attitudes and dropout. Informed by frameworks of person-environment-fit and results from educational psychology, we consider satisfaction with one’s studies and achievement as potential mediators, influencing the relations between attitudes and early dropout. Our results within a sample of 274 first-year students, enrolled in a pure mathematics or a teacher education program at a German university, show that interest in university mathematics and mathematical self-concept are associated with less risk to drop out. In the case of interest, this relation is mediated by students’ satisfaction, and in the case of self-concept, this relation is mediated by satisfaction and achievement. Based on these results, we discuss how to support students during the transition from school to university mathematics in order to prevent early dropout.
Analysis of safety and efficacy of proton radiotherapy for IDH-mutated glioma WHO grade 2 and 3
Authors: Eichkorn Tanja , Lischalk Jonathan W. , Hörner-Rieber Juliane , Deng Maximilian , Meixner Eva , Krämer Anna , Hoegen Philipp , Sandrini Elisabetta , Regnery Sebastian , Held Thomas , Harrabi Semi , Jungk Christine , Herfarth Klaus , Debus Jürgen , König Laila 
Published: January 2023

Abstract
Purpose
Proton beam radiotherapy (PRT) has been demonstrated to improve neurocognitive sequelae particularly. Nevertheless, following PRT, increased rates of radiation-induced contrast enhancements (RICE) are feared. How safe and effective is PRT for IDH-mutated glioma WHO grade 2 and 3?

Methods
We analyzed 194 patients diagnosed with IDH-mutated WHO grade 2 (n = 128) and WHO grade 3 (n = 66) glioma who were treated with PRT from 2010 to 2020. Serial clinical and imaging follow-up was performed for a median of 5.1 years.

Results
For WHO grade 2, 61% were astrocytoma and 39% oligodendroglioma while for WHO grade 3, 55% were astrocytoma and 45% oligodendroglioma. Median dose for IDH-mutated glioma was 54 Gy(RBE) [range 50.4–60 Gy(RBE)] for WHO grade 2 and 60 Gy(RBE) [range 54–60 Gy(RBE)] for WHO grade 3. Five year overall survival was 85% in patients with WHO grade 2 and 67% in patients with WHO grade 3 tumors. Overall RICE risk was 25%, being higher in patients with WHO grade 2 (29%) versus in patients with WHO grade 3 (17%, p = 0.13). RICE risk increased independent of tumor characteristics with older age (p = 0.017). Overall RICE was symptomatic in 31% of patients with corresponding CTCAE grades as follows: 80% grade 1, 7% grade 2, 13% grade 3, and 0% grade 3 + . Overall need for RICE-directed therapy was 35%.

Conclusion
These data demonstrate the effectiveness of PRT for IDH-mutated glioma WHO grade 2 and 3. The RICE risk differs with WHO grading and is higher in older patients with IDH-mutated Glioma WHO grade 2 and 3.