bluuebunny/crossref_metadata_2025_split huggingface dataset:
Induction of labor and risk of postpartum hemorrhage in women with vaginal delivery: A propensity score analysis
Authors: Braund Sophia , Deneux‐Tharaux Catherine , Sentilhes Loïc , Seco Aurélien , Rozenberg Patrick , Goffinet François 
Published: August 2023

AbstractObjectiveTo explore the association between induction of labor (IOL) and postpartum hemorrhage (PPH) after vaginal delivery.MethodsWe included women from the merged database of three randomized prospective trials (TRACOR, CYTOCINON, and TRAAP) that measured postpartum blood loss precisely, with standardized methods. IOL was considered overall and according to its method. The association between IOL and PPH was tested by multivariate logistic regression modeling, adjusted for confounders, and by propensity score matching. The role of potential intermediate factors, i.e. estimated quantity of oxytocin administered during labor and operative vaginal delivery, was assessed with structural equation modeling.ResultsLabor was induced for 1809 of the 9209 (19.6%) women. IOL was associated with a significantly higher risk of PPH of 500 mL or more (adjusted odds ratio 1.56, 95% confidence interval 1.42–1.70) and PPH of 1000 mL or more (adjusted odds ratio 1.51, 95% confidence interval 1.16–1.96). The risk of PPH increased similarly regardless of the method of induction. The results were similar after propensity score matching (odds ratio for PPH ≥500 mL 1.57, 95% confidence interval 1.33–1.87, odds ratio for PPH ≥1000 mL 1.57, 95% confidence interval 1.06–2.07). Structural equation modeling showed that 34% of this association was mediated by the quantity of oxytocin administered during labor and 1.3% by women who underwent operative vaginal delivery.ConclusionAmong women with vaginal delivery, the risk of PPH is higher in those with IOL, regardless of its method, and after accounting for indication bias. The quantity of oxytocin administered during labor may explain one third of this association.
Postoperative outcomes and urodynamic findings after continence mesh removal
Authors: Palmieri Stefania , Kuria Esther , Gonzales Gwendoline , Sarfoh Raymond , Elneil Sohier 
Published: August 2023

AbstractObjectiveTo analyze urodynamics findings and patient‐reported outcomes after removal of a mid‐urethral mesh because data regarding outcomes following mesh removal vary in different studies, and mesh removal itself may have risks.MethodsWomen who were referred to the Female Pelvic Medicine and Reconstructive Surgery Department of University College London Hospital and underwent vaginal removal of a continence mesh between January 2014 and January 2020, were included. Patient clinical data and results of video‐urodynamics investigations performed 4 months after mesh removal were collected and analyzed retrospectively.ResultsIn all, 204 patients were included in the study. After mesh removal, 80.5% of patients reported recurrent stress urinary incontinence (SUI), 10.1% reported prolapse symptoms, 8% reported voiding dysfunction and 2.9% reported overactive bladder (OAB) symptoms. Video‐urodynamics investigations confirmed the presence of SUI (67.6%), mixed urinary incontinence (14.3%), detrusor overactivity (DO) (6.8%) and voiding dysfunction in one patient. In two women a urethral stricture was described, and 10 women were deemed to have a significant cystocele.ConclusionRecurrence of SUI was the most frequent finding after continence mesh removal, both symptomatically and objectively. Women seldom reported OAB symptoms, but urodynamics showed evidence of DO despite this. On the other hand, voiding dysfunction was often reported but less often proven on urodynamics.
Optimal allocation of urban and rural water supply in coastal water shortage cities: The case of Yingkou City
Authors: Lv Yufeng , Yu Na , Sun Haibo , Li Hongpeng , Yang Jifu 
Published: August 2023

AbstractCoastal cities play a significant role in regional economic development and national water resource supply. However, the shortage of water resources in coastal cities has become a bottleneck for sustainable economic, social and ecological development. As a typical coastal city in Liaoning province, China, Yingkou has a relatively developed economy, but faces increasingly serious water shortages. Taking Yingkou as a case study, this study analysed the current situation of urban and rural water supply and conducted a rational estimation of the water supply and demand based on the time series method in the short‐term (2025) and long‐term (2035). Then, the allocation of urban and rural water supply was carried out on the principle of priority use of surface water, sufficient use of diverted water, expanding use of unconventional water and limited use of underground water. To achieve the optimal scheme, the method of ‘allocation‐feedback‐regulation‐reallocation’ was adopted to coordinate the water sources and consumption in different districts and sectors. Overall, the results clarified the red line of water consumption in 2025 and 2035 and defined water consumption and water sources in different sectors and districts. Finally, the water supply and demand balance in Yingkou and its subdistricts was achieved with surplus water rates of 6% and 7% in 2025 and 2035, respectively. Based on these results, suggestions for the sustainable development and utilization of water resources in Yingkou and coastal cities were proposed.
Calculating 13C NMR chemical shifts of large molecules using the eXtended ONIOM method at high accuracy with a low cost
Authors: Ke Zhipeng , Weng Jingwei , Xu Xin 
Published: August 2023

AbstractFragmentation‐based methods for nuclear magnetic resonance (NMR) chemical shift calculations have become more and more popular in first‐principles calculations of large molecules. However, there are many options for a fragmentation‐based method to select, such as theoretical methods, fragmentation schemes, the number of levels of theory, etc. It is important to study the optimal combination of the options to achieve a good balance between accuracy and efficiency. Here we investigate different combinations of options used by a fragmentation‐based method, the eXtended ONIOM (XO) method, for 13C chemical shift calculations on a set of organic and biological molecules. We found that: (1) introducing Hartree‐Fock exchange into density functional theory (DFT) could reduce the calculation error due to fragmentation in contrast to pure DFT functionals, while a hybrid functional, xOPBE, is generally recommended; (2) fragmentation schemes generated from the molecular tailoring approach (MTA) with small level parameter n, for example, n = 2 and the degree‐based fragmentation method (DBFM) with n = 1, are sufficient to achieve satisfactory accuracy; (3) the two‐level XO (XO2) NMR calculation is superior to the calculation with only one level of theory, as the second level (i.e., low level) of theory provides a way to well describe the long‐range effect. These findings are beneficial to practical applications of fragmentation‐based methods for NMR chemical shift calculations of large molecules.
Fluorescein isothiocyanate‐tagged boronic acid sensor‐based pH‐dependent discerning tannic acid detection
Authors: Akram Raheel , Arshad Anila , Saqib Muhammad 
Published: August 2023

AbstractBackground and purposeThe distinction of tannic acid (TA) in the presence of other analogues, i.e., gallic acid (GA), dopamine (DA), glucose (Glu), and fructose (Fruc), containing vicinal diols, has long been a significant yet challenging task due to their similar chemical structures and minuscule levels.MethodsHere, the integration of 3‐aminophenyl boronic acid‐modified fluorescein isothiocyanate (3‐APBA‐FITC) for pH‐dependent ultrasensitive and selective detection of TA in wines was proposed. By performing fluorescence signal off and pH‐dependent boronate‐ester bond synthesis, the suggested probe may specifically identify TA.ResultsThe as‐prepared 3‐APBA‐FITC designed probe had shown ultrahigh sensitivity with a limit of detection (LOD) of 0.151 μM. Finally, in detecting TA in artificial wine with a recovery between 92.49‐93.05 % and a relative standard deviation of no more than 2.0 %, the designed strategy has been successfully applied.ConclusionTherefore, the envisaged sensing strategy can be an interesting option for discerning detection of diols containing analytes in food products.
Commutability evaluation of candidate reference materials and ERM‐DA470k/IFCC for immunoglobulin M using two international approaches
Authors: Sang Lu , Wu Chunying , Chen Huijuan , Liu Wei , Huang Dawei , Yang Xi , Guo Xinrui , Cui Ruifang , Wang Ning , Zhang Rui , Yue Yuhong , Guo Hong , Wang Minghao , Miao Yutong , Wang Qingtao , Zhang Shunli 
Published: August 2023

AbstractBackgroundThis study aimed to assess the commutability of frozen pooled human serum (PHS), high concentration of Immunoglobulin M (IgM) pure diluted materials (HPDM), commercialized pure materials (CPM), and dilutions of ERM‐DA470k/IFCC in IgM detection using the CLSI and IFCC approaches, to support standardization or harmonization of IgM measurement.MethodsTwenty‐four serum samples, relevant reference materials (PHS, HPDM, CPM), and different ERM‐DA470k/IFCC dilutions were analyzed in triplicate using six routine methods. The commutability of the relevant reference materials was carried out following CLSI EP30‐A and IFCC bias analysis.ResultsAccording to the CLSI approach, low, medium, and high concentrations of PHS, HPDM, and CPM were commutable on 10, 13, 15, 13, and 8 of 15 assay combinations, respectively. Using the IFCC approach, low, medium, and high concentrations of PHS, HPDM, and CPM were commutable on 10, 11, 9, 15, and 10 of 15 assay combinations, respectively. The ERM‐DA470k/IFCC dilutions with D‐PBS and RPMI‐1640 Medium were commutable on 13 of 15 assay combinations according to CLSI and were commutable on all 15 assay combinations using IFCC approach.ConclusionsHigh concentration of PHS were commutable on all six detection systems using the CLSI approach. Low and medium concentration of PHS showed unsatisfied commutability. HPDM, not CPM have good commutability, has the potential to become reference materials. ERM‐DA470k/IFCC diluted with different medium showed different commutability.
Amiodarone‐Induced Nystagmus and Ataxia: Case Report and Systematic Review of Case Reports
Authors: Kaur Paawanjot , Kaur Ashampreet , Sinha Amitasha , Khaliq Waseem , Dumic Igor , Singh Amteshwar 
Published: August 2023

AbstractAmiodarone is an antiarrhythmic drug with a significant adverse effect profile, including neurotoxicity. While ataxia, neuropathy, and tremors are more commonly seen forms of amiodarone neurotoxicity, very few cases of nystagmus are reported. We report the case of an 86‐year‐old man who presented with abrupt‐onset ataxia, dizziness, and inability to ambulate, 10 days after initiating amiodarone for atrial fibrillation. His examination revealed gaze‐evoked nystagmus along with features of cerebellar dysfunction. After excluding other etiologies, amiodarone was stopped. His nystagmus resolved, and his ataxia improved within 48 h of stopping amiodarone. Due to the rarity of this drug‐induced adverse effect, we performed a systematic review of available case reports in the literature (PubMed and Scopus) using Preferred Reporting Items for Systematic Reviews and Meta‐Analyses guidelines and presented our findings. Nystagmus is a rarely reported adverse effect of amiodarone, which can occur within days to months of starting the medication. Treatment includes stopping the drug and monitoring for resolution of nystagmus.
Student empathy in standardized patient experiences: Applying concepts from a critical thinking emulation model
Authors: Brendan Young Lance , Johnsen David C. , Shi Wei 
Published: August 2023

AbstractIntroductionClinician empathy can improve patient outcomes, but the literature is scant on patient‐based, student‐led experiences to demonstrate the projection of empathy in patient interactions.Purpose/objectives(1) Develop a learning guide for observable behaviors communicating emotional and cognitive empathy and (2) determine whether the learning guide can be used as a rubric for assessing empathy in a standardized patient experience.MethodsEleven standardized patients assessed 80 D3 students using a 4‐point interval scale on 19 behavioral criteria in four domains: Initiation (four criteria); Health History and Caries Risk (four criteria); Treatment Planning (six criteria); and Communication Skills (five criteria). Standardized patients also provided qualitative feedback.ResultsStandardized patients completed all 1520 interval scales on the rubric and 94% of 320 open‐ended entries. Students performed well. Of the 1520 criterion interval scales, 1242 (81.7%) were rated “excellent.” Wilcoxon signed‐rank tests revealed Initiation scores (Mean [M] = 3.82, Standard deviation [SD] = 0.28) and Treatment Planning scores (M = 3.82, SD = 0.36) were significantly higher than Health History Scores (M = 3.75, SD = 0.34; p < 0.05). Qualitative feedback also was overwhelmingly positive for Treatment Planning and more equivocal for Health History.ConclusionsThe emulation model for students to demonstrate observable aspects of empathy is viable as both a learning guide and evaluation rubric in a standardized patient format. The next steps include the development of a succinct skillset for reinforcement in the patient setting and continued discussion on what best captures core observable aspects of empathy.
Brewing better connections: Coffee with the dean to enhance admin‐student communication
Authors: Siqueira Walter L. , Greig Lisa 
Published: August 2023

AbstractEffective communication is pivotal in nurturing a supportive learning atmosphere. At the University of Saskatchewan's College of Dentistry, traditional methods like emails and meetings seemed inadequate in engaging all students. Concerns stemmed from power dynamics and limited dialogue avenues. To bridge this gap, an innovative solution emerged. Introducing "Coffee with the Dean": A bi‐weekly event fostering informal discussions between students and the dean. Set in a relaxed ambiance, students openly covered diverse topics. The project aimed to foster transparent communication and bolster a sense of unity. Implemented over six months, the initiative saw significant outcomes. Assessment involved an anonymous survey to DMD students, garnering a 34% response rate. Impressively, 89% acknowledged enhanced communication, with 53% and 23% expressing high and moderate satisfaction in asking questions and providing feedback. Moreover, 67% displayed a likelihood to attend future sessions. A notable 89% appreciated the project's community‐building impact. Although challenges emerged, including scheduling and participation constraints, the project achieved its goal. The casual setup facilitated student expression and prompted insightful exchanges. The experience emphasizes the importance of secure dialogue spaces and consistent communication channels. "Coffee with the Dean" stands as a potent tool for heightened student‐administration interaction. Its role in elevating communication aligns with the quest for educational excellence, ensuring holistic student growth.
Microscopic morphology and distribution of the antennal sensilla in the double‐spined bark beetle, Ips duplicatus (Coleoptera: Curculionidae)
Authors: Shewale Mayuri Kashinath , Nebesářová Jana , Grosse‐Wilde Ewald , Kalinová Blanka 
Published: August 2023

AbstractThe double‐spined spruce bark beetle, Ips duplicatus, has become an infamous secondary pest of Norway spruce, causing extensive ecological and economic destruction in many Central European countries. Antennae are the primary olfactory organs that play a fundamental role in insect‐host chemical communication; therefore, understanding morphology is crucial before conducting electrophysiological investigations. Here, we present our analysis of sensilla types on the antennal surface of I. duplicatus for the first time, using high‐resolution‐scanning electron microscopy. We studied the external morphological characteristics of antennae and the types, numbers, and distribution of the antennal sensilla in males and females. Our results revealed the presence of five different types of morphologically distinct sensilla: sensilla chaetica, sensilla basiconica, sensilla trichodea, sensilla coeloconica, and Böhm's sensilla. We observed two subtypes of sensilla chaetica (SChI and SChII), four subtypes of sensilla basiconica (SBI, SBII, SBIII, and SBIV), three subtypes of sensilla trichodea (STrII, STrIII, and STrIV) and two subtypes of sensilla coeloconica (SCoI and SCoII), respectively in I. duplicatus males and females. Minor differences in length and numbers between the sexes for some sensilla types were found. Distribution maps for different sensillar types were constructed, and specific areas for the respective sensilla were found. Possible functions of observed sensilla types are discussed. The present study provides a basis for future electrophysiological studies to understand how I. duplicatus detects ecologically important olfactory cues.Research Highlights
The first report of morphology and distribution pattern of the antennal sensilla in Ips duplicatus is discussed.
A total of 6 main types and 11 antennal sensilla subtypes were observed in male and female Ips duplicatus.
Minor sex‐specific differences were seen in the length and numbers in several sensilla types.
Enhancing the didactic learning experience for Laboratory Genetics and Genomics fellows through a multi‐institutional lecture series
Authors: Leung Marco L. , Cottrell Catherine E. 
Published: August 2023

AbstractAs a result of the pandemic, the traditional in‐person didactic lecture model was adapted to a virtual learning approach. Our Laboratory Genetics and Genomics fellowship program at Nationwide Children's hospital took advantage of this opportunity to organize a multi‐institutional Fellow's Conference to educate fellows from different programs on a wide range of medical genetics topics. We describe our approach of developing this lecture series utilizing subject‐matter experts across institutions. In addition, we discuss the value of such an approach in reducing the amount of time individual institutions spend creating and providing didactic content for their small number of learners. Our experience could serve as a model for other educators and program directors, including genetic counseling program directors, to develop multi‐institutional collaborations for didactic learning.
Disease knowledge and health literacy in parents of children with sickle cell disease
Authors: Ikediashi Bonaventure G. , Ehrmann Cristina , Gomez Selma , Michel Gisela 
Published: August 2023

AbstractWe aimed to (1) describe sickle cell disease (SCD) knowledge and health literacy levels in parents of children with SCD, (2) examine associations with socio‐demographic factors and (3) analyse the association with hospital admissions and frequency of occurrence of painful episodes. Parents who presented with their child at routine hospital consultation at the National Sickle Cell Disease Centre in Benin were administered a questionnaire assessing SCD knowledge, health literacy (newest vital sign [NVS]) and socio‐demographic and clinical characteristics. In total, 117 parents participated (108, 92.3% females). The predominant SCD genotype was HbSS (79.5%). The average SCD knowledge score was 13.6 (standard deviation [SD] = 2.0). Only 34 (29.1%) participants correctly answered ≥70% of the questions, indicating good knowledge. Health literacy was relatively low (mean NVS score = 3.3; SD = 1.1). SCD knowledge was higher in parents with older children (p = 0.001) and higher education levels (primary, p = 0.010; tertiary, p = 0.036 compared to participants with no formal education). Hospital admissions were more frequent when parents had lower SCD knowledge (p = 0.034) and in parents with younger children (p = 0.039). No associations were found between health literacy and hospital admissions (p = 0.940) and frequency of occurrence of painful episodes (p = 0.224). Continuous disease‐specific education for parents of children with SCD may help them better identify and prevent the occurrence of symptoms and decrease the number of hospital admissions.
The Effect of Image Resampling on the Performance of Radiomics‐Based Artificial Intelligence in Multicenter Prostate MRI
Authors: Bleker Jeroen , Roest Christian , Yakar Derya , Huisman Henkjan , Kwee Thomas C. 
Published: August 2023

BackgroundSingle center MRI radiomics models are sensitive to data heterogeneity, limiting the diagnostic capabilities of current prostate cancer (PCa) radiomics models.PurposeTo study the impact of image resampling on the diagnostic performance of radiomics in a multicenter prostate MRI setting.Study TypeRetrospective.PopulationNine hundred thirty patients (nine centers, two vendors) with 737 eligible PCa lesions, randomly split into training (70%, N = 500), validation (10%, N = 89), and a held‐out test set (20%, N = 148).Field Strength/Sequence1.5T and 3T scanners/T2‐weighted imaging (T2W), diffusion‐weighted imaging (DWI), and apparent diffusion coefficient maps.AssessmentA total of 48 normalized radiomics datasets were created using various resampling methods, including different target resolutions (T2W: 0.35, 0.5, and 0.8 mm; DWI: 1.37, 2, and 2.5 mm), dimensionalities (2D/3D) and interpolation techniques (nearest neighbor, linear, Bspline and Blackman windowed‐sinc). Each of the datasets was used to train a radiomics model to detect clinically relevant PCa (International Society of Urological Pathology grade ≥ 2). Baseline models were constructed using 2D and 3D datasets without image resampling. The resampling configurations with highest validation performance were evaluated in the test dataset and compared to the baseline models.Statistical TestsArea under the curve (AUC), DeLong test. The significance level used was 0.05.ResultsThe best 2D resampling model (T2W: Bspline and 0.5 mm resolution, DWI: nearest neighbor and 2 mm resolution) significantly outperformed the 2D baseline (AUC: 0.77 vs. 0.64). The best 3D resampling model (T2W: linear and 0.8 mm resolution, DWI: nearest neighbor and 2.5 mm resolution) significantly outperformed the 3D baseline (AUC: 0.79 vs. 0.67).Data ConclusionImage resampling has a significant effect on the performance of multicenter radiomics artificial intelligence in prostate MRI. The recommended 2D resampling configuration is isotropic resampling with T2W at 0.5 mm (Bspline interpolation) and DWI at 2 mm (nearest neighbor interpolation). For the 3D radiomics, this work recommends isotropic resampling with T2W at 0.8 mm (linear interpolation) and DWI at 2.5 mm (nearest neighbor interpolation).Evidence Level3Technical EfficacyStage 2