bluuebunny/crossref_metadata_2025_split huggingface dataset:
Safety, Feasibility, and Efficacy of Additional Extraventricular Anterior Commissurotomy With Corpus Callosotomy
Authors: Kosugi Kenzo , Yoshitomi Munetake , Takayama Yutaro , Iijima Keiya , Kimura Yuiko , Kaneko Yuu , Toda Masahiro , Iwasaki Masaki 
Published: January 2023

BACKGROUND:
Corpus callosotomy (CC) is a palliative neurosurgical procedure for patients with intractable epilepsy and without resectable focal epileptogenic lesions. Anterior commissurotomy (AC) has been historically performed with CC. However, the efficacy and safety of adding AC to CC remain unknown.

OBJECTIVE:
To describe the surgical technique of extraventricular AC and retrospectively investigate its clinical efficacy and safety by assessing patients who underwent CC with and without AC.

METHODS:
AC has been added to CC at our institution since 2018. Fifty-five consecutive patients who received total callosotomy from 2016 to 2020 were included and categorized into 2 groups: 26 patients with additional AC and 29 patients without additional AC. Seizure outcome 1 year after surgery were compared between groups for assessing the efficacy of adding AC. The perioperative factors were compared for assessing the safety and feasibility.

RESULTS:
Seizure reduction rate (50% and 60%; P = .60) and disappearance of drop attacks (42% and 58%; P = .25) were not significantly different between CC and CC + AC groups. No statistical group differences were found in intraoperative estimated blood loss, number of days to first oral intake, duration of postoperative intravenous hydration, and length of hospital stay.

CONCLUSION:
Disconnection of the anterior commissure is a feasible and relatively safe procedure. This study failed to show the significant efficacy of adding AC to CC. However, further investigation is needed to prove its efficacy in ameliorating epilepsy.
Splashed E-box and AP-1 motifs cooperatively drive regeneration response and shape regeneration abilities
Authors: Tamaki Teruhisa , Yoshida Takafumi , Shibata Eri , Nishihara Hidenori , Ochi Haruki , Kawakami Atsushi 
Published: January 2023

ABSTRACTInjury triggers a genetic program that induces gene expression for regeneration. Recent studies have identified regeneration-response enhancers (RREs); however, it remains unclear whether a common mechanism operates in these RREs. We identified three RREs from the zebrafish fn1b promoter by searching for conserved sequences within the surrounding genomic regions of regeneration-induced genes and performed a transgenic assay for regeneration response. Two regions contained in the transposons displayed RRE activity when combined with the −0.7 kb fn1b promoter. Another non-transposon element functioned as a stand-alone enhancer in combination with a minimum promoter. By searching for transcription factor-binding motifs and validation by transgenic assays, we revealed that the cooperation of E-box and activator protein 1 motifs is necessary and sufficient for regenerative response. Such RREs respond to variety of tissue injuries, including those in the zebrafish heart and Xenopus limb buds. Our findings suggest that the fidelity of regeneration response is ensured by the two signals evoked by tissue injuries. It is speculated that a large pool of potential enhancers in the genome has helped shape the regenerative capacities during evolution.
Hox genes in development and beyond
Authors: Hubert Katharine A. , Wellik Deneen M. 
Published: January 2023

ABSTRACT
Hox genes encode evolutionarily conserved transcription factors that are essential for the proper development of bilaterian organisms. Hox genes are unique because they are spatially and temporally regulated during development in a manner that is dictated by their tightly linked genomic organization. Although their genetic function during embryonic development has been interrogated, less is known about how these transcription factors regulate downstream genes to direct morphogenetic events. Moreover, the continued expression and function of Hox genes at postnatal and adult stages highlights crucial roles for these genes throughout the life of an organism. Here, we provide an overview of Hox genes, highlighting their evolutionary history, their unique genomic organization and how this impacts the regulation of their expression, what is known about their protein structure, and their deployment in development and beyond.
Cytochrome c1-like is required for mitochondrial morphogenesis and individualization during spermatogenesis in Drosophila melanogaster
Authors: Chen Meng-Yan , Duan Xin , Wang Qian , Ran Mao-Jiu , Ai Hui , Zheng Ya , Wang Yu-Feng 
Published: January 2023

ABSTRACT
The Drosophila testis is an excellent system for studying the process from germ stem cells to motile sperm, including the proliferation of male germ cells, meiosis of primary spermatocytes, mitochondrial morphogenesis, and spermatid individualization. We previously demonstrated that ocnus (ocn) plays an essential role in male germ cell development. Among those genes and proteins whose expression levels were changed as a result of ocn knockdown, cytochrome c1-like (cyt-c1L) was downregulated significantly. Here, we show that cyt-c1L is highly expressed in the testis of D. melanogaster. Knockdown or mutation of cyt-c1L in early germ cells of flies resulted in male sterility. Immunofluorescence staining showed that cyt-c1L knockdown testes had no defects in early spermatogenesis; however, in late stages, in contrast to many individualization complexes (ICs) composed of F-actin cones that appeared at different positions in control testes, no actin cones or ICs were observed in cyt-c1L knockdown testes. Furthermore, no mature sperm were found in the seminal vesicle of cyt-c1L knockdown testes whereas the control seminal vesicle was full of mature sperm with needle-like nuclei. cyt-c1L knockdown also caused abnormal mitochondrial morphogenesis during spermatid elongation. Excessive apoptotic signals accumulated in the base of cyt-c1L knockdown fly testes. These results suggest that cyt-c1L may play an important role in spermatogenesis by affecting the mitochondrial morphogenesis and individualization of sperm in D. melanogaster.
“Redes partidárias transnacionais” na América Latina? Coerência ideológica entre partidos e candidaturas presidenciais (2000-2015) | “Transnational Party Networks” in Latin America? Ideological coherence between parties and presidential candidates (2000-2015)
Authors: Oliveira Augusto Neftali Corte de , Marques Teresa Cristina Schneider , Carvalho Felipe Rocha de 
Published: January 2023

A pesquisa investiga cinco organizações internacionais de partidos políticos que operaram durante a onda rosa da América Latina, entre 2000 e 2015. Identificou-se a filiação internacional dos partidos com candidaturas presidenciais em 16 países da América Latina. Por meio de análise de conteúdo, foram identificadas as proposições de política pública e a posição ideológica de 155 programas de governo. Uma contribuição específica da pesquisa é revelar que a associação internacional operou como um identificador ideológico coerente dos partidos e das diretrizes de política pública expressas nas disputas presidenciais. Abre-se a possibilidade, portanto, para futuras investigações sobre as conexões transnacionais na produção e difusão de proposições programáticas no momento eleitoral e seus eventuais reflexos nas políticas públicas domésticas e externas dos governos eleitos.Palavras-chave: Partidos políticos. Organizações internacionais. Eleições presidenciais.ABSTRACTThe research investigates five international organizations of political parties that were active during the pink tide in Latin America. We identified the international affiliation of parties with presidential candidacies in 16 Latin American countries. Through content analysis, we were able to pinpoint public policy propositions and the ideological position of about 150 government programs. A specific contribution of the research is to reveal that international affiliation operated as a coherent ideological identifier of parties and public policy guidelines, which were expressed in presidential disputes. This unfolds the possibility for future investigations regarding transnational connections in the production and dissemination of programmatic propositions and their effects on domestic and foreign public policies of elected governments.Keywords: Political parties. International organizations. Presidential elections. Recebido em: 19 abr. 2022 | Aceito em: 15 set. 2022.
Estudos sobre Análise de Política Externa na Colômbia: um campo em construção | Studies on Foreign Policy Analysis in Colombia: a field under construction
Authors: Gonçalves Fernanda Cristina Nanci Izidro 
Published: January 2023

Resumo: Este artigo apresenta reflexões sobre a política externa da Colômbia e sobre como a literatura especializada em Análise de Política Externa (APE) buscou explicá-la. Para tanto, apresenta-se como as mudanças na condução da política exterior nos últimos 20 anos vêm sendo discutidas pelos pesquisadores e mapeiam-se as principais contribuições dos estudos de APE nacionais. Por fim, apresentam-se os desafios encontrados por essa subárea das Relações Internacionais na Colômbia, destacando-se que esta subdisciplina ainda está em fase de construção e discutem-se os novos olhares sobre a política externa do país, que estão buscando abrir a “caixa-preta” e avaliar o processo decisório.Palavras-chave: Análise de Política Externa. Colômbia. Política Exterior. Abstract: This article presents reflections on Colombia's foreign policy and how specialized literature on Foreign Policy Analysis (FPA) has sought to explain it. To this end, it is presented how changes in the practice of foreign policy in the last 20 years have been discussed by researchers and it is discussed the main contributions of Foreign Policy Analysis (FPA) studies nationally. Then, are presented the challenges faced by this área of International Relations in Colombia, highlighting that this subdiscipline is still under construction and are also discussed new perspectives that are seeking to open the “black box” and evaluate the decision-making process on the country's foreign policy.Keywords: Foreign Policy Analysis. Colombia. Foreign Policy. Recebido em: 20 mai. 2022 | Aceito em: 30 nov. 2022.
Onde estão elas? As mulheres na política externa brasileira a partir da análise dos discursos do país em sessões de abertura da Reunião Anual da Assembleia Geral das Nações Unidas de 1946 a 2015 | Where are they? Women in Brazilian foreign policy – an analysis of the country's speech at opening sessions of the annual meeting of the United Nations General Assembly from 1946 to 2015
Authors: Zanella Cristine Koehler , Mateus Robbi Amanda 
Published: January 2023

O artigo investiga presença e a ausência da mulher na Política Externa Brasileira (PEB), a partir da análise de conteúdo, pela qual busca-se, nos discursos do Brasil nas sessões de abertura dos debates das reuniões anuais da Assembleia Geral das Nações Unidas (AGNU), os dados quantitativos e qualitativos sobre o objeto de estudo. O período analisado vai de 1946 a 2015, cobrindo todos os governos brasileiros que encerraram seu mandato, desde a criação da Organização das Nações Unidas (ONU) até o primeiro governo de uma mulher no Brasil. Da análise realizada observa-se o fechamento da PEB às questões de gênero ao longo da ditadura brasileira, mesmo em um contexto de forte promoção internacional dos direitos das mulheres. Por outro lado, o período pós-redemocratização revela maior reconhecimento desta temática. Finalmente, conclui-se pela maior presença da temática nos discursos de Dilma Rousseff, única mulher a chefiar o Executivo brasileiro até o momento.Palavras-chave: Política Externa Brasileira. Análise de política externa, Mulheres.ABSTRACTThe article investigates the presence and absence of women in Brazilian Foreign Policy (PEB), based on content analysis, which searches for quantitative and qualitative data on the object of study in Brazil's speeches at the opening sessions of the annual meetings of the United Nations General Assembly (AGNU). The analyzed period goes from 1946 to 2015, covering all Brazilian governments that ended their mandate, from the creation of the United Nations (UN) until the first government of a woman. From the analysis carried out we observe the PEB's closure to gender issues throughout the Brazilian dictatorship, even in a context of strong international promotion of women's rights. On the other hand, the post-democratization period reveals greater recognition of this theme. Finally, we conclude that there is a greater presence of the theme in the speeches of Dilma Rousseff, the only woman to head the Brazilian Executive Branch so far.Keywords: Brazilian Foreign Policy. Foreign policy analysis. Women. Recebido em: 15 jun. 2022 | Aceito em: 28 nov. 2022.
Identifying the hotspot area of Indo-Pacific humpback (Sousa chinensis) and Irrawaddy (Orcaella brevirostris) dolphins in Matang waters, Perak, Malaysia
Authors: Mat Sobri Muhammad Fadhli , Jaaman Saifullah Arifin , Mohamed Zulqarnain , Muda Azmi Marzuki , Abd Rashid Muhammad Amirul Siddiq , Zhang Xuelei 
Published: January 2023

Abstract. Sobri MF, Jaaman SA, Mohamed Z, Muda AM, Rashid MASA, Zhang X. 2022. Identifying the hotspot area of Indo Pacific humpback (Sousa chinensis) and Irrawaddy (Orcaella brevirostris) dolphins in Matang waters, Perak, Malaysia. Biodiversitas 23: 6106-6113. The Indo-Pacific humpback (Sousa chinensis) and Irrawaddy (Orcaella brevirostris) dolphins are commonly found in Matang waters, Perak, Malaysia. The area, filled with healthy mangrove forest cover and many estuaries, is not only frequented by the dolphins for its daily activities but also extensively used by locals for artisanal fishing, charcoal production and organizing ecotourism activities. There could be a high risk of human-dolphin interactions, hence determining habitat use and identifying critical habitats or "hot spots" for the dolphins in the area is important. In this study, a series of dedicated boat sighting surveys were conducted from March 2019 to January 2021 between Kuala Gula and Kuala Jarum Mas. The total survey effort was 3325.76 km, 44 days and 239.38 hours. A total of 69 dolphin sightings were made, consisting of 40 Indo-Pacific humpback dolphins and 29 Irrawaddy dolphin observations, respectively. During each sighting, every dolphin's behaviors were categorized as: foraging, socializing, evasive, and travelling, and the survey area was classified into four blocks. The results indicated that different dolphin species have different hotspot areas. For Indo-Pacific humpback dolphins, the hotspot area was Kuala Sangga, while the Irrawaddy dolphin's hotspot area was outside Kuala Larut, and there was a small overlap between the two dolphins' hotspots. Among the recorded behaviors (n: 281) for both dolphins, the most dominant was foraging (72.24%), followed by socializing (17%), evasive (7%), and travelling (4%). The sighted foraging behavior for both dolphin populations was dominant, indicating the hot spots were major foraging grounds for the two dolphin populations. This study shows the importance of Matang waters as a conservation area for the species and warrants further studies of dolphin population ecology to be conducted.
A comparative study between biological and chemical control against domestic mosquito larvae
Authors: Habiba Gacem , Imen Khalfallah , Rabeh Chaouich , Lina Lefilef 
Published: January 2023

Abstract. Habiba G, Imen K, Rabeh C, Lina L. 2022. A comparative study between biological and chemical control against domestic mosquito larvae. Biodiversitas 23: 6456-6462. Mosquitoes are the first cause of transmission of viral diseases to both humans and animals, as they can transmit some viral diseases. These insects have attracted the attention of specialists, especially in the field of control, because they have controlled their spread in urban areas. Traditionally, they have resorted only to insecticides to eliminate them, and aquatic organisms have long been used to assess the health of aquatic systems. Extensive use of pesticides in agricultural and public health programs has caused many environmental problems and toxic effects on aquatic animals, especially non-target organisms. Hence, this method has negative effects. Later, another method appeared called "biological control", which is based on natural predators. The current study aims to compare the use of biological and chemical control in eliminating mosquito larvae without causing any damage to the ecosystem. Therefore, two studies were conducted. The first is biological control by placing water mites with local mosquito larvae and measuring mite mortality, while the second study deals with chemical control. The rust solution was tested on mosquito larvae at different doses of 0.5mL/L, 2.5mL/L, and 4.5 mL/L. The results proved the effectiveness of biological control compared to chemical control. Finally, these findings will greatly contribute to both the agricultural and medical fields that infect this insect, as well as enrich the literature for future research in mosquitoes.
Interrelationship Penunaian Ibadah Haji Dengan Kedaulatan dan Keutuhan NKRI
Authors: Robingun Suyud El Syam  , Salis Irvan Fuadi  , Machfudz  
Published: January 2023

Menjaga kedaulatan dan keutuhan NKRI merupakan kewajiban setiap warga negara. Tindakan menipu calon jemaah haji Furoda dengan visa palsu berarti menciderai negara di mata dunia Internasional. Penelitian menggunakan pendekatan eksplanatif untuk menjelaskan kedudukan dan hubungan antara ibadah haji dengan kedaulatan dan keutuhan NKRI, memakai data lietatur untuk diolah dan dianalisis komparatif. Penelitian menghasilkan: bahwa ibadah haji merupakan ritual yang memberi kesan mendalam terhadap umat sehingga bisa menumbuhkan militansi ilmu yang mumpuni dan semangat juang tinggi. Semangat ini mampu menggerakkan orang bertindak berani mengorbankan jiwa raga atas nama negara demi agama. Di sini terdapat aksi dan reaksi timbal balik antara keduanya, di satu sisi ibadah haji bisa ditunaikan bagi warga negera yang berdaulat, dan negara membutuhkan warganya untuk mewujudkan dan menjaga kedaulatannya. Relasi timbal balik ini saling mengikat satu sama lain sehingga menjadi keutuhan NKRI, maka segala tindakan yang menimbulkan persepsi buruk bagi Indonesia termasuk kategori menciderai kedaulatan dan keutuhan NKRI.
Kata kunci: Interrelationship, Haji, Kedaulatan, Keutuhan, NKRI
KOMODIFIKASI AGAMA: STUDI ANALISIS TERHADAP TAMPILAN AGAMA DI INSTAGRAM
Authors: Cut Asri  , Moh Soehadha  
Published: January 2023

Kemajuan teknologi menghantarkan berbagai kemudahan dalam pemenuhan kebutuhan dengan waktu yang cepat. Penggunaan smartphone yang hampir dimiliki oleh seluruh kalangan di masyarakat membuat masyarakat dapat dengan mudah mengakses internet, sehingga dengan itu berbagai informasi pun akan dengan mudah didapatkan sesuai dengan kebutuhan. Beberapa manfaat yang dimungkinkan dari penggunaanya diantaranya adalah dapat digunakan untuk bertukar pendapat sesama pengguna, sebagai media promosi bisnis, menjadi tempat untuk memperluas pergaulan dan jaringan, saling memberi penilaian, bahkan dapat pula digunakan untuk bertukar file atau dokumen. Dalam perkembangannya media massa erat kaitanya dengan komodifikasi. Komodifikasi dapat diartikan sebagai proses mengubah barang dan jasa termasuk komunikasi yang dinilai karena kegunaanya, menjadi komoditas yang dinilai karena apa yang mereka berikan di pasar. Jenis penelitian yang digunakan adalah penelitian netnografi.Tampilan agama di Instagram memberikan peluang besar terhadap agama untuk tampil secara online, namun peluang ini dipergunakan oleh pilik pemiliki akun Instragram @kembalijijrah @literasiislamcinta, @kajianmalamminggu, @santun.inv, @duniajilbab untuk mengembangkan perekonomian dalam berbagai bentuk sehingga memberikan nilai tukar baik dalam bentuk agama dalam bisnis, agama dalam bentuk literasi, menyampaikan dakwak-dakwah secara online. Dalam hal ini maka dapat disebut dengan komodifikasi agama karena menggunakan simbol-simbol agama dan materi agama untuk akomodasi nilai tukar.
Kata Kunci: Komodifikasi; Tampilan Agama; Instagram
Restraint stress during neonatal hypoxia‐ischemia alters brain injury following normothermia and hypothermia
Authors: Gundersen Julia K. , Sabir Hemmen , Wood Thomas R. , Osredkar Damjan , Falck Mari , Loeberg Else M. , Walloe Lars , Menassa David A. , Thoresen Marianne 
Published: January 2023

AbstractRodent models of neonatal hypoxic–ischemic (HI) injury require a subset of animals to be immobilized for continuous temperature monitoring during the insult and subsequent treatment. Restrained animals are discarded from the analysis due to the effect of restraint on the brain injury as first demonstrated by Thoresen et al 1996. However, the effects of restraint on responses to hypothermic (HT) post‐insult therapy are not well described. We examine the effects of restraint associated with different probe placements on HI brain injury. We have conducted a meta‐analysis of 23 experiments comparing probe rats (skin n = 42, rectal n = 35) and free‐moving matched non‐probe controls (n = 80) that underwent HI injury (left common carotid artery ligation and 90 min 8% O2) at postnatal day 7 (P7), followed by 5 h of NT (37°C) or HT (32°C). On P14, brain regions were analyzed for injury (by neuropathology and area loss), microglial reactivity and brain‐derived neurotrophic factor (BDNF). HI injury was mitigated in NT skin and rectal probe rats, with greater neuroprotection among the rectal probe rats. Following HT, the skin probe rats maintained the restraint‐associated neuroprotection, while brain injury was significantly exacerbated among the rectal probe rats. Microglial reactivity strongly correlated with the acquired injury, with no detectable difference between the groups. Likewise, we observed no differences in BDNF signal intensity. Our findings suggest a biphasic neuroprotection from restraint stress, which becomes detrimental in combination with HT and the presumed discomfort from the rectal probe. This finding is useful in highlighting unforeseen effects of common experimental designs or routine clinical management.
Antibiotics in avian care and husbandry-status and alternative antimicrobials
Authors: Lepczyński Adam , Herosimczyk Agnieszka , Bucław Mateusz , Adaszyńska-Skwirzyńska Michalina 
Published: January 2023

Abstract
Undoubtedly, the discovery of antibiotics was one of the greatest milestones in the treatment of human and animal diseases. Due to their over-use mainly as antibiotic growth promoters (AGP) in livestock farming, antimicrobial resistance has been reported with increasing intensity, especially in the last decades. In order to reduce the scale of this phenomenon, initially in the Scandinavian countries and then throughout the entire European Union, a total ban on the use of AGP was introduced, moreover, a significant limitation in the use of these feed additives is now observed almost all over the world. The withdrawal of AGP from widespread use has prompted investigators to search for alternative strategies to maintain and stabilize the composition of the gut microbiota. These strategies include substances that are used in an attempt to stimulate the growth and activity of symbiotic bacteria living in the digestive tract of animals, as well as living microorganisms capable of colonizing the host’s gastrointestinal tract, which can positively affect the composition of the intestinal microbiota by exerting a number of pro-health effects, i.e., prebiotics and probiotics, respectively. In this review we also focused on plants/herbs derived products that are collectively known as phytobiotic.