bluuebunny/crossref_metadata_2025_split huggingface dataset:
Epidemiology and Clinical Outcomes of Non-HACEK Gram-Negative Infective Endocarditis
Authors: Shah Sunish , Clarke Lloyd G , Shields Ryan K 
Published: February 2023

AbstractBackgroundThe objectives of this study were to describe the changing epidemiology of gram-negative infective endocarditis (GNIE) and to identify factors associated with treatment failure and death.MethodsAdult patients with GNIE were included if they met modified Duke criteria for definitive infective endocarditis (IE) between April 2010 and December 2021. Patients were identified using Boolean search terms. Clinical failure was a defined as a composite of all-cause 42-day mortality or microbiologic failure. All analyses were performed using Stata, version 15.1.ResultsOne-hundred twenty-three patients were included. The most common pathogens were Serratia spp. (43%), Pseudomonas aeruginosa (21%), and Klebsiella spp. (14%). Fifty-two percent of cases were among persons who injection drugs (PWID; n = 64), for whom Serratia spp. (70%) was the most common cause of GNIE. Overall, patients infected with P. aeruginosa had higher microbiologic failure rates than other patients (23% vs 6%; P = .004). Patients who received combination therapy (n = 53) had comparable median lengths of stay (23 vs 19.5 days; P = .412), microbiologic failure rates (11.3% vs 7.1%; P = .528), clinical failure rates (18.9% vs 22.9%; P = .592), and 90-day mortality rates (13.2% vs 25.7%; P = .088) as those treated with monotherapy. After applying stepwise logistic regression, male gender, Pitt Bacteremia Score, and not receiving surgical intervention despite a surgical indication were associated with clinical failure.ConclusionsThis is the first study to identify Serratia spp. as the most common etiology of GNIE, which was particularly true among PWID. Microbiologic failures occurred most commonly among P. aeruginosa, and use of combination antimicrobial therapy did not improve clinical outcomes.
Managing Ibrutinib-Intolerant Patients With B-Cell Malignancies
Authors: Muñoz Javier , Sarosiek Shayna , Castillo Jorge J 
Published: February 2023

AbstractIbrutinib is a first-generation inhibitor of Bruton tyrosine kinase (BTK) that is currently approved to treat patients with B-cell malignancies, including Waldenström macroglobulinemia (WM), relapsed/refractory (R/R) mantle cell lymphoma (MCL), R/R marginal zone lymphoma (MZL), and chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL). Off-target adverse effects, such as atrial fibrillation, hypertension, and bleeding, have been observed and may limit a patient’s tolerance for treatment. Currently, there is no well-established treatment regimen for patients who cannot tolerate ibrutinib. Approaches to address such patients include managing ibrutinib side effects with supportive care or dose reductions, switching to an alternative covalent BTK inhibitor, or abandoning covalent BTK inhibitors for alternative forms of treatment. Here we review the literature and provide guidance on treating ibrutinib-intolerant patients with B-cell malignancies.
Prevalence and Associations of Beta2-Microglobulin Mutations in MSI-H/dMMR Cancers
Authors: Liu Fangcen , Zhong Fangfang , Wu Huan , Che Keying , Shi Jiaochun , Wu Nandie , Fu Yao , Wang Yue , Hu Jing , Qian Xiaoping , Fan Xiangshan , Wang Weifeng , Wei Jia 
Published: February 2023

AbstractMicrosatellite instability (MSI) has emerged as an important predictor of sensitivity for immunotherapy-based strategies. β-2-Microglobulin (B2M) contains microsatellites within the coding regions and is prone to somatic changes in MSI/mismatch repair deficiency (MSI/dMMR) tumors. To delineate prevalence and associations of B2M mutations in MSI-H/dMMR cancers, we investigated the mutational profile of B2M and clinical and pathological features in gastric cancer (GC), colorectal cancer (CRC), and endometrial cancer (EC) with a high incidence of microsatellite instability-high (MSI-H)/dMMR. Formalin-fixed paraffin-embedded (FFPE) tumor tissues along with matched normal tissues were collected from 108 MSI/dMMR patients with GC, CRC, and EC. Genomic profiling of tissue and blood samples were assessed next-generation sequencing (NGS). Immunohistochemistry (IHC) was used to examine the presence or absence of B2M protein. Alternations in the exonic microsatellite regions of B2M were observed at various but high frequencies (57.5% in CRC, 23.9% in GC, and 13.6% in EC) and in different forms. NGS assay revealed that genes involved in chromatin regulation, the PI3K pathway, the WNT pathway, and mismatch repair were extensively altered in the MSI-H cohort. Signature 6 and 26, 2 of 4 mutational signatures associated with defective DNA mismatch repair, featured with high numbers of small insertion/deletions (INDEL) dominated in all 3 types of cancer. Alternations in the exonic microsatellite regions of B2M were observed at various but high frequencies (57.5% in CRC, 23.9% in GC, and 13.6% in EC) and in different forms. Tumor mutational burden (TMB) was significantly higher in the patients carrying MSI-H/dMMR tumors with B2M mutation than that in patients with wild-type B2M (P = .026).The frame shift alteration occurring at the exonic microsatellite sties caused loss of function of B2M gene. In addition, a case with CRC carrying indels in B2M gene resisted the ICI treatment was reported. In conclusion, patients carrying MSI-H/dMMR tumors with B2M mutation showed significantly higher TMB. Prescription of ICIs should be thoroughly evaluated for these patients.
Galaxy clusters at z ∼ 1 imaged by ALMA with the Sunyaev–Zel’dovich effect
Authors: Kitayama Tetsu , Ueda Shutaro , Okabe Nobuhiro , Akahori Takuya , Hilton Matt , Hughes John P , Ichinohe Yuto , Kohno Kotaro , Komatsu Eiichiro , Lin Yen-Ting , Miyatake Hironao , Oguri Masamune , Sifón Cristóbal , Takakuwa Shigehisa , Takizawa Motokazu , Tsutsumi Takahiro , van Marrewijk Joshiwa , Wollack Edward J 
Published: February 2023

AbstractWe present high angular resolution measurements of the thermal Sunyaev–Zel’dovich effect (SZE) toward two galaxy clusters, RCS J2319+0038 at $z$ = 0.9 and HSC J0947−0119 at $z$ = 1.1, by the Atacama Large Millimeter/submillimeter Array (ALMA) in Band 3. They are supplemented with available Chandra X-ray data, optical data taken by Hyper Suprime-Cam on Subaru, and millimeter-wave SZE data from the Atacama Cosmology Telescope. Taking into account departures from spherical symmetry, we have reconstructed non-parametrically the inner pressure profile of two clusters as well as electron temperature and density profiles for RCS J2319+0038. This is one of the first such measurements for an individual cluster at $z \gtrsim 0.9$. We find that the inner pressure profile of both clusters is much shallower than that of local cool-core clusters. Our results consistently suggest that RCS J2319+0038 hosts a weak cool core, where radiative cooling is less significant than in local cool cores. On the other hand, HSC J0947−0119 exhibits an even shallower pressure profile than RCS J2319+0038 and is more likely to be a non-cool-core cluster. The SZE centroid position is offset by more than 140 $h_{70}^{-1}$ kpc from the peaks of galaxy distribution in HSC J0947−0119, suggesting a stronger influence of mergers in this cluster. We conclude that these distant clusters are at a very early stage of developing the cool cores typically found in clusters at lower redshifts.
Ingestion rate estimated from food concentration and predatory role of copepod nauplii in the microbial food web of temperate embayment waters
Authors: Sugai Youta , Natori Noriaki , Tsuchiya Kenji , Nakagawa Megumi , Honda Makio C , Shimode Shinji , Toda Tatsuki 
Published: February 2023

AbstractTo quantitatively evaluate the role of copepod nauplii as predators in the microbial food web, the ingestion rate (IR) of copepod nauplii and the food requirement (FR) of microzooplankton were estimated monthly for 3 consecutive years in temperate embayment waters. The IR of dominant copepod nauplii (Acartia spp. nauplii) was estimated from water temperature, individual carbon weight and food concentration and peaked (&gt;0.50 μgC ind−1 d−1) with relatively high food concentration (&gt;57.5 μgC L−1). This result suggests that food concentration should be considered to estimate copepod naupliar IR in marine environments, especially where biological conditions fluctuate largely. The comparison of copepod naupliar and microprotozoan FR showed the dominance of naked ciliate FR (77.0–90.2%) during the study period except in spring when comparable values were observed between the FR of naked ciliates (41.6%) and copepod nauplii (33.6%). During spring, transfer efficiency (10.5%) from primary production (PP) to microzooplankton production was lower than in other seasons (16.2–17.1%). This study indicates that copepod nauplii are seasonally important micro-sized predators in the microbial food web of temperate embayment waters and that carbon flow through copepod nauplii is a pathway which inefficiently transfers PP to higher trophic levels.
The role of sleep and heart rate variability in metabolic syndrome: evidence from the Midlife in the United States study
Authors: Nevels Torrance L , Wirth Michael D , Ginsberg J P , McLain Alexander C , Burch James B 
Published: February 2023

Abstract

Study Objectives
Poor sleep and autonomic dysregulation can both disrupt metabolic processes. This study examined the individual and combined effects of poor sleep and reduced heart rate variability (HRV) on metabolic syndrome among 966 participants in the Midlife in the United States II (MIDUS II) study.

Methods
Self-reported sleep was assessed using the Pittsburgh Sleep Quality Index (PSQI). HRV was acquired from 11-minute resting heart rate recordings. Spearman correlations, general linear regression, and logistic regression models were used to examine the study hypotheses.

Results
Poor sleep quality was associated with metabolic syndrome when global PSQI scores were evaluated as a continuous (odds ratio [OR]: 1.07, 95% confidence interval [CI]: 1.03 to 1.11) or categorical measure (cutoff &gt; 5, OR: 1.58, 95% CI: 1.19 to 2.10), after adjustment for confounding. There also was an association between reduced HRV and metabolic syndrome (ln [HF-HRV] OR: 0.89, 95% CI: 0.80 to 0.99; ln [LF-HRV] OR: 0.82, 95% CI: 0.72 to 0.92; ln [SDRR] OR: 0.59, 95% CI: 0.43 to 0.79; ln [RMSSD] OR: 0.75, 95% CI: 0.60 to 0.94). When the combined effects of poor sleep and low HRV were examined, the association with metabolic syndrome was further strengthened relative to those with normal sleep and HRV.

Conclusions
To the best of the author’s knowledge, this is the first study to suggest a combined effect of poor sleep and low HRV on the odds of metabolic syndrome.
Counternarratives: An Antiracist Approach in Social Work Education, Practice, and Research
Authors: Berrett-Abebe Julie , Reed Sarah C , Burrell Storms Stephanie 
Published: February 2023

AbstractGiven renewed attention to racial equity in the social work profession, the authors suggest the use of counternarratives, an established tool of critical race theory, as an accessible method to challenge racism and examine privilege in social work education, practice, and research. Counternarratives use the technique of storytelling to elevate the lived experiences of marginalized individuals and communities and invite the listener into critical reflection about dominant, privileged discourses. The ultimate goal of counternarratives is the achievement of racial equity. The authors provide context about how counternarratives can align with social work education, practice, and research, and then use specific, illustrative examples from their own work to bring this method and its application to life. The authors also share their own processes of reflection and dialogue across disciplines and social locations in the use of counternarratives. The reflections of an experienced social justice educator provide additional insights on the use of counternarratives in the field of social work.
HexSE: Simulating evolution in overlapping reading frames
Authors: Muñoz-Baena Laura , Wade Kaitlyn E , Poon Art F Y 
Published: February 2023

AbstractGene overlap occurs when two or more genes are encoded by the same nucleotides. This phenomenon is found in all taxonomic domains, but is particularly common in viruses, where it may provide a mechanism to increase the information content of compact genomes. The presence of overlapping reading frames (OvRFs) can skew estimates of selection based on the rates of non-synonymous and synonymous substitutions, since a substitution that is synonymous in one reading frame may be non-synonymous in another and vice versa. To understand the impact of OvRFs on molecular evolution, we implemented a versatile simulation model of nucleotide sequence evolution along a phylogeny with any distribution of open reading frames in linear or circular genomes. We use a custom data structure to track the substitution rates at every nucleotide site, which is determined by the stationary nucleotide frequencies, transition bias and the distribution of selection biases (dN/dS) in the respective reading frames. Our simulation model is implemented in the Python scripting language. All source code is released under the GNU General Public License version 3 and are available at https://github.com/PoonLab/HexSE.
Graduate Nurse Educator Students’ Perceptions of the Use of Narrative Pedagogy in Online Learning
Authors: Kim-Godwin Yeoun Soo , Matthias April D. , Dieckman Laura P. 
Published: February 2023

Abstract
This pilot study explored graduate nurse educator students’ perceptions of the application of narrative pedagogy in an online environment. Four major themes were identified in 15 student discussion posts: adapting challenges, increasing digital human interactions, enabling strategies, and creating a partnership for learning. Results illustrate how integrating narrative pedagogy into online classes enables a transformation of student thinking and learning by providing alternate ways for nurse educators to promote active learning.
Telepresence: An Innovative Teaching Modality to Enrich Simulation and Remote Learning
Authors: Want David R. , Cieslowski Bethany J. 
Published: February 2023

Abstract
The COVID-19 pandemic magnified the need for simulation and necessitated a radical change in how educators execute simulation-based learning (SBL), highlighting new and emerging technologies. Student evaluations noted a lack of realism with screen-based and telesimulations, and faculty reported students’ decreased engagement. This project enhanced SBL using robot telepresence to provide an immersive and interactive environment. Student comments supported the positive experience, expressing greater engagement and indicating that the experience closely mirrored clinical practice. Telepresence removes barriers to distance learning, augments the potential of SBL, and broadens the understanding of how to deliver engaging SBL experiences to remote learners.
Virtual Suturing Lab: A Practical and Innovative Approach in Nursing Education
Authors: McClinton Tracy D. 
Published: February 2023

Abstract
Competency in a variety of skills is necessary for undergraduate and advanced practice nursing students prior to entering the clinical setting. Basic suturing is traditionally taught in skills labs in advanced practice programs globally. However, when in-person teaching is not an option, nurse educators must be innovative in meeting clinical course outcomes. A virtual suturing skills lab proved to be beneficial in meeting the needs of advanced practice nursing students when in-person teaching was not feasible. Students demonstrated competency using an innovative method of teaching a hybrid program through distance learning.
Socialization of Master's-Prepared Novice Nurse Faculty
Authors: Nicholls Lakeisha N. , Kelman Glenda B. 
Published: February 2023

Abstract

AIM
The aim of this study was to explore the lived experience of novice nurse faculty's socialization to academia.

BACKGROUND
Socialization is a process that enables individuals to acquire the inherent roles, standards, rules, and values inherent of a group. Given the complexity of the faculty role, socialization is essential for novice nurse educators.

METHOD
A descriptive, qualitative study was conducted employing Colaizzi's phenomenological method of data analysis.

RESULTS
Eight themes emerged: lack of structure, the blind spot, distinctive experiences, acceptance and validation, continually evolving—learning as you go, the wish list, new role challenges, and self-revelation.

CONCLUSION
These findings increase our understanding of the challenges experienced by novice nursing faculty as they are socialized to their new roles. The findings can inform strategies to improve the socialization experience and faculty retention.
Updates in school-based asthma management
Authors: Lowe Ashley A. , Onge Ina St , Trivedi Michelle 
Published: February 2023

Purpose of review
School-based asthma management is an important component of pediatric asthma care that has the potential to provide more universal evidence-based asthma care to children and mitigate asthma-related health inequities. The purpose of this review is to highlight relevant developments in school-based asthma management over the past 2 years.

Recent findings
There have been considerable recent scientific advances in school-based asthma management including robust clinical trials of environmental interventions in the classroom setting, school-nurse led interventions, stock albuterol policy changes, school-based telemedicine approaches and innovative methods to engage community stakeholders in research that have pushed the frontiers of school-based asthma care.

Summary
Recent scientific work in school-based asthma management demonstrates the potential power of schools in providing access to guideline-based asthma care for all children with asthma and in improving their health outcomes. Future work should focus on the evaluation of methods to promote the adoption of school-based asthma management strategies in real-world practice and support evidence-based policy change and strategic partnerships to improve asthma health outcomes and produce meaningful public health impact for diverse children and families.
Update on irritant-induced occupational asthma
Authors: Ronsmans Steven , Le Moual Nicole , Dumas Orianne 
Published: February 2023

Purpose of review
In this narrative review, we aim to highlight novel research findings on both acute/subacute irritant-induced asthma (IIA) and chronic exposure IIA (also called ‘low dose’ IIA).

Recent findings
Novel case series showed that acute and subacute IIA cases had similar causal agents (e.g., acid or base aerosols/fumes, dusts, mixtures) but had occurred in different circumstances (accidents vs. regular work). Acute and subacute IIA cases had similar clinical characteristics but poorer short-term outcomes than sensitizer-induced occupational asthma patients. Novel large epidemiological studies reported associations between chronic occupational exposure to irritants and current adult-onset asthma and poor asthma control, and with a specific asthma endotype characterized by neutrophilic inflammation and oxidative stress. Recent studies reconfirmed the association of the use of disinfectants and cleaning products (especially sprays) with IIA. A role for genetic susceptibility has been suggested.

Summary
Recent literature provided further understanding of both acute/subacute and chronic exposure IIA, in terms of causes, possible mechanisms, and consequences such as poor asthma control. Research is needed to clarify several aspects of IIA, including its frequency (still likely underestimated), modulating factors, and mechanisms. Research aiming at improving irritant exposure assessment, including intensity/duration, and determining relevant exposure windows would be welcome.
Biochemical disturbance in damage control resuscitation: mechanisms, management and prognostic utility
Authors: Milne Andrew , Radhakrishnan Archchana 
Published: February 2023

Purpose of review
With advances in resuscitative techniques, trauma patients are surviving increasingly severe injuries and physiological insult. Timely recognition of futility remains important in terms of patient dignity and resource preservation yet is increasingly challenging in the face of these advances. The understanding of biochemical derangement from pathophysiological processes of trauma and iatrogenic effects of resuscitation has expanded recently.

Recent findings
Acidosis and hypocalcaemia have been recognized as important contributors to mortality among trauma patients. Although less well recognized and studied, critical injury and high blood product volume resuscitation render patients vulnerable to life-threatening hyperkalaemia. The methods of correcting disruptions to acid–base and electrolyte homeostasis during damage control resuscitation have changed little recently and often rely on evidence from undifferentiated populations. Biochemical disturbances have value as ancillary predictors of futility in trauma resuscitation.

Summary
These findings will contribute to a greater understanding among anaesthesiologists of the causative mechanisms and effects of biochemical derangement after severe injury and aid them in the delivery of well tolerated and effective damage control resuscitation. Gaps in the evidence base are highlighted to encourage future work.
Is it time to move on from pelvic radiography as the first-line imaging modality for suspected sacroiliitis?
Authors: Eshed Iris , Diekhoff Torsten , Hermann Kay Geert A. 
Published: February 2023

Purpose of review
Pelvic radiography in which structural lesions characteristic of sacroiliitis can be detected, is recommended as the first imaging modality when axial spondyloarthritis (axSpA) is suspected clinically. However, cross-sectional modalities like computed tomography (CT) and magnetic resonance imaging (MRI) are superior to radiographs for diagnosing sacroiliitis. Thus, we currently debate the role of radiography as first imaging modality in the diagnostic workup of axSpA.

Recent findings
Diagnosing sacroiliitis on pelvic radiographs is challenging with large interobserver and intraobserver variation. Low-dose CT (ldCT) of the sacroiliac joints (SIJs) was proved to be more sensitive and reliable than radiographs with comparable ionizing radiation exposure. MRI is the preferred modality for detecting early SIJ inflammation, well before structural lesions evolve. New, promising MRI sequences sensitive to cortical bone improve erosion detection, making MRI a one-stop shop for the diagnosis of sacroiliitis.

Summary
Given the debatable additive value of pelvic radiographs for the detection of sacroiliitis, and the presence of excellent alternatives for imaging the bony cortex of the SIJs such as ldCT and MRI with state-of-the-art sequences sensitive to cortical bone, it is high time to discuss the use of these more accurate modalities instead of radiographs.