bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Survey on E-Commerce Learning to Rank
Authors: Kabir Md Ahsanul , Hasan Mohammad Al , Mandal Aritra , Tunkelang Daniel , Wu Zhe 
Published: March 2023

Abstract
In e-commerce, ranking the search results based on users’ preference is the most important task. Commercial e-commerce platforms, such as, Amazon, Alibaba, eBay, Walmart, etc. perform extensive and relentless research to perfect their search result ranking algorithms because the quality of ranking drives a user’s decision to purchase or not to purchase a product, directly affecting the profitability of the e-commerce platform. In such a commercial platforms, for optimizing search result ranking numerous features are considered, which emerge from relevance, personalization, seller’s reputation and paid promotion. To maintain their competitive advantage in the market, the platforms do no publish their core ranking algorithms, so it is difficult to know which of the algorithms or which of the features are the most effective for finding the most optimal search result ranking in e-commerce. No extensive surveys of learning to rank (LTR) in the e-commerce domain as such is not yet published. In this work, we survey the existing e-commerce learning to rank algorithms. Besides, we also compare these algorithms based on query relevance criterion on a large real-life e-commerce dataset and provide a quantitative comparison. To the best of our knowledge this is the first such survey which include an experimental comparison among various learning to rank algorithms.
Future water security under climate change: a perspective of the Grand River Watershed
Authors: Kaur Baljeet , Shrestha Narayan Kumar , Ghimire Uttam , Paul Pranesh Kumar , Rudra Ramesh , Goel Pradeep , Daggupati Prasad 
Published: March 2023

Abstract
Climate change poses a threat to the water security of the Grand River Watershed (GRW) by altering the precipitation patterns and other weather variables, which affect streamflow and freshwater availability. Therefore, in this study, a Soil and Water Assessment Tool (SWAT) model for the GRW, Ontario, Canada, was used to assess the blue and green water scarcity for future periods for future sustainable management of freshwater resources in the region. The ensemble results predicted a warmer and wetter future for the GRW. The ensemble model result, when considering both emission scenarios and future periods, showed that blue water (BW) is projected to increase by 23–40% while green water storage (GWS) is projected to experience an overall decrease (2–8%). The results suggested that BW may become more scarce compared to green water in the future. The scarcity of BW is primarily due to the projected increase in population growth and water demand in the watershed. Green water scarcity in some regions indicated that changes in irrigation might be needed in the future in some parts of the watershed. The results indicate that the careful planning is essential for future water management in GRW.
Ganaxolone: First FDA-approved Medicine for the Treatment of
Seizures Associated with Cyclin-dependent Kinase-like 5 Deficiency
Disorder
Authors: De Surya K. 
Published: March 2023

Abstract:
The neurosteroids progesterone and allopregnanolone control numerous neuroprotective
functions in neural tissues, including inhibition of epileptic seizures and cell
death. Ganaxolone (3α-hydroxy-3β-methyl-5α-pregnan-20-one) (GNX) is the 3β-
methylated synthetic analog of allopregnanolone and an allosteric GABAA positive modulator.
Ganaxolone reduces the frequency of CDD-associated seizures.
Effectiveness and Safety of Traditional Chinese Medicine in Treatment of
Primary Sjögren’s Syndrome Patients: A Meta-analysis
Authors: Liu Hui , Wang Xiaoxin , Liu Weiran , He Guannan , Liang Xiaodong , Bian Yuejuan 
Published: March 2023

Backgroud:
Primary Sjögren’s Syndrome (pSS) is an autoimmune disease. It can damage
the salivary and lacrimal glands and is characterized by dry mouth and eye symptoms, which
seriously affects people’s normal life. Both modern medicine and Traditional Chinese medicine
(TCM) have certain effects in treating SS. However, there are different theories about which treatment
is more appropriate.

Objective:
The aim of this research was to compare the efficacy and safety of TCM to Western
Medicine in the treatment of pSS.

Methods:
We collected randomized controlled trials (RCTs) of TCM, integrating traditional Chinese
and Western medicine for the treatment of pSS in Chinese and foreign databases.

Results:
A total of 13 articles were eventually included with 780 cases. The final results were expressed
in odds ratio (OR), mean difference (MD), 95% confidence interval (CI), and overall effect
(z). The effective rate was 86.03% in the TCM group and 67.75% in the western medicine group.
Results of the effective rate were OR = 3.57; 95% CI = 2.44-5.23; z = 6.56; p＜0.00001, ESR were
MD = -6.90; 95% CI = -10.76--3.05; z = 3.51; p = 0.0005＜0.05, Schirmer’s test were MD = 3.39; 95%
CI = 1.92-4.86; z = 4.5; p＜0.00001, salivary flow were MD = 0.62; 95% CI = 0.16-1.07; z = 2.63; p =
0.009＜0.05, and adverse reactions were OR = 0.35; 95% CI = 0.17-0.72; z = 2.84; p = 0.004.

Conclusion:
TCM has a remarkable effect on the treatment of pSS. Among them Yiguanjian decoction
and Liuwei Dihuang decoction were effective prescriptions with the highest frequency of
application. Rehmanniae Radix (Rehmannia glutinosa Libosch.) and Ophiopogonis Radix (Ophiopogon
japonicus (L. f.) Ker-Gawl.) were the most frequently used TCM.
Erythrocyte-based Drug Delivery: How Far from Clinical Application?
Authors: Jiang Yuan , Yuan Yi , Peng Feng , Deng Yi , Ren Chao , Liu Chongzhi , Dong Hai , Tu Tao 
Published: March 2023

Abstract:Erythrocytes are responsible for delivering oxygen throughout the body. They have become suitable drug carriers due to outstanding advantages, such as a long lifespan in circulation, high biosafety, and low immunogenicity. Although erythrocyte-based drug delivery has good application prospects and has become a research hotspot in related fields, the application of erythrocyte-based drug delivery systems is rare in the clinic now. In this review, we discuss the characteristics of erythrocytes, diverse drug-loading approaches, and research progress of erythrocyte-based drug delivery systems. Finally, we explore the challenges of erythrocyte-based drug delivery in clinical application.
Measuring Brain Temperature in Youth Bipolar Disorder Using a Novel
Magnetic Resonance Imaging Approach: A Proof-of-concept Study
Authors: Zou Yi , Heyn Chinthaka , Grigorian Anahit , Tam Fred , Andreazza Ana Cristina , Graham Simon J. , Maclntosh Bradley J. , Goldstein Benjamin I. 
Published: March 2023

Background:
There is evidence of alterations in mitochondrial energy metabolism and cerebral
blood flow (CBF) in adults and youth with bipolar disorder (BD). Brain thermoregulation is
based on the balance of heat-producing metabolism and heat-dissipating mechanisms, including CBF.

Objective:
To examine brain temperature, and its relation to CBF, in relation to BD and mood symptom
severity in youth.

Methods:
This study included 25 youth participants (age 17.4 ± 1.7 years; 13 BD, 12 control group
(CG)). Magnetic resonance spectroscopy data were acquired to obtain brain temperature in the left anterior
cingulate cortex (ACC) and the left precuneus. Regional estimates of CBF were provided by arterial
spin labeling imaging. Analyses used general linear regression models, covarying for age, sex,
and psychiatric medications.

Results:
Brain temperature was significantly higher in BD compared to CG in the precuneus. A higher
ratio of brain temperature to CBF was significantly associated with greater depression symptom severity
in both the ACC and precuneus within BD. Analyses examining the relationship of brain temperature or
CBF with depression severity score did not reveal any significant finding in the ACC or the precuneus.

Conclusion:
The current study provides preliminary evidence of increased brain temperature in youth
with BD, in whom reduced thermoregulatory capacity is putatively associated with depression symptom
severity. Evaluation of brain temperature and CBF in conjunction may provide valuable insight
beyond what can be gleaned by either metric alone. Larger prospective studies are warranted to further
evaluate brain temperature and its association with CBF concerning BD.
Association of a Genetic Variant in Chromosome 9p21 with Increased Risk
of Developing Cervical Cancer
Authors: Atabati Mojde , Saber Razieh , Malakuti Parnian , Pourali Ghazaleh , Heydari-Majd Motahareh , Safavi Pegah , Dashti Mohammad , Moghadam Azam Rastgar , Rahmani Farzad , Farazestanian Marjaneh , Behboodi Negin , Mehramiz Mehrane , Nassiri Mohammadreza , Rajabian-Noghondar Majid , Rahbarian Raheleh , Ramshini Hassan , Jafarian Amirhosein , Ferns Gordon , Avan Amir , Hasanzadeh Malihe 
Published: March 2023

Background:
Cervical cancer is one of the most prevalent gynecologic cancers associated
with high morbidity and mortality worldwide. There is mounting evidence indicating an association
between the 9p21 locus genetic variants with susceptibility to various human malignancies. In this current
study, we aimed to evaluate the potential relationship between the rs1333049 genetic variant in
chromosome 9p21 and the risk of cervical carcinogenesis.

Methods:
The possible correlation between rs1333049 polymorphism and susceptibility to cervical
cancer was investigated in 221 patients with or without cancer. DNAs were isolated and genotyped using
a TaqMan-based real-time RT-PCR method.

Results:
The rs1333049 genetic variant was found to be correlated with an elevated risk of cervical neoplasia
using recessive and additive genetic models (p < 0.001).

Conclusion:
Our findings indicated that the CDKN2A/B genetic variant (rs1333049) was significantly
associated with an elevated risk of cancer, suggesting its potential as a novel predictive marker for cervical
carcinogenesis.
Rarer Components of a Rare Disease: Accessory Hemidiaphragm and
Horseshoe Lung with Scimitar Syndrome: Two Case Reports
Authors: Koska Ozgur I. , Alper Hüdaver 
Published: March 2023

Introduction:
Scimitar syndrome is a rare developmental anomaly with an incidence of 2/100.000 births. Major components of this disease are partial anomalous
pulmonary venous drainage, pulmonary hypoplasia, systemic arterialization of the right basal lung, and dextroposition of the heart. Horseshoe lung
and accessory hemidiaphragm are two rarer components of this disease.

Case Presentation:
In this paper, horseshoe lung and accessory diaphragm associated with Scimitar syndrome have been reported in two cases.

Conclusion:
In conclusion, being aware of rare manifestations of rare diseases is important to fully describe the pathologic spectrum of the disease. This will
assist in better management and decision-making process.
An Overview on Sources, Biosynthesis and Bioactivities of Osthole: A
Potential Bioactive Compound
Authors: Singh Gurdeep , Singh Mukesh Kr. 
Published: March 2023

Abstract:
Different plants are rich in medicinal properties, which nature has provided in abundance
for the living beings of this earth. Since the dawn of time, nature has proven to be a rich
source of bioactive scaffolds that have been exploited in the creation of pharmaceuticals. Osthole
is a natural coumarin derivative and potential bioactive compound found in plants. Herein, we
aimed to review the origins, biology and pharmacological profiles of osthole, a plant-derived
coumarin that is found in a variety of therapeutic plants, including Cnidium monnieri. Osthole,
also called 7-methoxy-8-(3-methyl-2-butenyl)-2H-1-benzopyran-2-one, is a naturally occurring
coumarin found to be present in different plants of the Apiaceae family, i.e., Cnidium monnieri
and Angelica pubescens. The biological potential of the osthole in medicine has been investigated
using a variety of literature databases. This study gathered diverse scientific research data on
osthole from various literature sources and analysed, including Scopus, Google Scholar, Web of
Science and PubMed. From the collected data, it was found that osthole have potential pharmacological
activities, such as anticancer, antioxidant, osteogenic, cardioprotective, antimicrobial, antiparasitic,
anti-hyperglycaemic, neuroprotective, and antiplatelet. The data in this review paper
supports the pharmacological potential of osthole, but to completely appreciate the pharmacological
potential of this therapeutically powerful chemical, researchers must focus their efforts on further
experimentation, biosafety profiling and synergistic effects of this compound. The purpose of
this study was to learn more about the origins, biology, and therapeutic benefits of osthole in medicine
in order to develop better treatments for human diseases.
Molecular Pathology and Therapeutic Strategies of Type 2 Diabetes
Authors: Liao Helen Ziqing , Liang Yanting , Wang Ye , Liang Chun 
Published: March 2023

Abstract:
Diabetes Mellitus (DM) is a metabolic disorder characterized by hyperglycemia. Over the years, scientists have identified many factors that may have causal relationships with DM develop-ment. Identified factors are either genetic or environmental, and they may promote or prevent DM development. This review discusses various factors that are involved in the molecular pathogenesis, development, and therapeutic strategies of type 2 diabetes. DM is caused by interactions between multiple factors and triggers. Altered metabolic pathways and cellular functions, primarily in organs involved in glucose metabolisms, such as the pancreas and liver, often result in metabolic dysfunc-tion, leading to DM. Additionally, abnormal levels of some factors, the presence of some pathogens, or the use of some types of medicine, such as immuno-inflammatory mediators, glucagon, apolipo-protein E4, chromogranin-A, exosomes, vitamin D, viruses, glucocorticoid medication, and antipsy-chotic drugs, may play roles in the development of DM. Some of these factors and mechanisms are well-studied, while others are more controversial and have contradicting experimental results. Further research is needed to confirm the roles of these factors in DM and fully understand how they contrib-ute to DM development. Numerous medications for diabetics have been developed to help alleviate the symptoms of hyperglycemia and its complications. Several types of small compounds or peptide drugs with anti-diabetic effects can decrease blood glucose levels, improve insulin resistance, and inhibit key enzymes involved in the development and progression of diabetes. Here, we review the commonly used effective antidiabetic drugs, including the most recent innovative ones, such as GLP-1R/GIPR and GLP-1R/GCGR agonists, and Chinese medicine.
Análisis de la oferta académica ofrecida por universidades públicas y privadas en Costa Rica para la carrera de Preescolar y su relación con la formación docente entre los años 2020 y 2021
Authors: Calvo-Achoy Mayte , Sanabria-Hernández Marcela 
Published: March 2023

En el presente artículo se plantean los resultados de la investigación que desarrolló la Cátedra de Psicopedagogía de la Universidad Estatal a Distancia (UNED) entre los años 2020 y 2021, cuyo objetivo fue analizar la oferta curricular que ofrecen tanto las universidades públicas como las privadas del país, en lo que respecta a la formación de profesionales de educación preescolar. En un primer momento, el artículo describe brevemente los hitos históricos que han marcado huella en la educación preescolar y, posteriormente, se hace una reflexión teórica sobre el perfil docente y la importancia de esta formación en la atención integral de niños y niñas. A nivel metodológico, la investigación se enmarca en un enfoque cualitativo que incorpora el análisis de la información, es decir, se establecen objetivos y criterios para revisar los datos, que a la postre brinden insumos que permitan su interpretación y análisis. Los resultados evidencian semejanzas y diferencias en la oferta curricular, así como los contenidos que debieran ser considerados para una atención integral hacia la población de la primera infancia y que no están presentes en los programas. A manera de conclusión, se evidencia la necesidad de ejecutar acciones de mejora en el área curricular, administrativa y de ingreso a las carreras, así como mejorar la coordinación entre diferentes instancias públicas y privadas que permitan una formación de calidad de las personas profesionales de la educación preescolar. Se espera que los resultados y las conclusiones de esta investigación sirvan de sustento para otros estudios y sean considerados en los ejercicios de diseño, rediseño y acreditación de las carreras de educación preescolar en el país.
Nat Turner’s Rebellion: A Chronicle of Major Events
Authors: Шумаков А.А. 
Published: March 2023

Восстание Ната Тернера, произошедшее в августе 1831 года в округе Саутгемптон, штат Вирджиния, является одним из самых знаковых и в то же время хорошо изученных и задокументированных событий американской истории. Тем не менее, можно с уверенностью утверждать, что в отечественной американистике должного внимания ему никогда не уделялось. До настоящего времени не вышло ни одного масштабного исследования. Даже сам ход восстания в русскоязычной литературе описан крайне поверхностно и, в основном, в публицистических работах, являющихся в большинстве своем переводом или компиляцией нескольких американских журналистских материалов. В данной статье автор попытался восполнить указанный пробел и восстановить общую картину и хронику событий, опираясь на источники и работы ведущих зарубежных специалистов по направлению «Афроамериканская история» (Black History) ⁎ . В статье подробно прослеживается маршрут продвижения группы мятежников по округу Саутгемптон и основные события, происходившие в активной фазе восстания, т.е. в период с 22 часов 21 августа до 5 часов утра 23 августа 1831 г. При этом вопросы выявления причин и предпосылок, а также непосредственной подготовки восстания автор намеренно опускает, фокусируясь исключительно на описании хода вооруженного выступления рабов. Автором предложена собственная периодизация восстания, а также определен круг причин его поражения.
Nat Turner’s Rebellion that took place in Southampton County, Virginia, in August 1831 is one of the most iconic and at the same time well-studied and documented events in American history. Nevertheless, it is safe to say that Russian American studies have never paid due attention to this issue. Not a single major study has been published so far. Even the course of the rebellion is described in Russian-language literature in a superficial manner mainly in popular science and journalistic works, which are mostly translations or compilations of several American journalistic materials. In this article, the author tried to fill this gap and to reconstruct the overall picture and chronicle of events, relying on the sources and works of leading foreign experts in the field of African American History (Black History).⁎ The article retraces in detail the advance of the rebel group through Southampton County and the main events that took place in the active phase of the rebellion, i.e. in the period between 10 p.m. on August 21 and 5 a.m. on August 23, 1831. The author deliberately omits the questions of identifying the causes and prerequisites of the rebellion as well as its immediate preparation, focusing exclusively on the description of the course of the armed slave uprising. The author proposes his own periodization of the rebellion and also determines the range of reasons for its defeat.
Vologda Merchant Gavriil (Gavrila) Fetiev: An Experiment of Personal Archaeography (About the Book by Marina Cherkasova) Review of Kupets G.M. Fetiev: issledovanie i arkhiv [Merchant G.M. Fetiev: Research and Archive] by M.S. Cherkasova (Vologda: Drevnosti Severa, 2020)
Authors: Всеволодов А.В. 
Published: March 2023

Рецензируемое исследование представляет собой первый опыт систематического изложения биографии крупнейшего вологодского купца XVII столетия Г.М. Фетиева, а также сводной публикации документальных материалов, связанных с его торговой и служебной деятельностью. Оно подводит итог почти двадцати лет работы автора – видного российского медиевиста, доктора исторических наук М.С. Черкасовой.
The study under review is the first attempt of a systematic presentation of Gavriil (Gavrila) Fetiev’s biography, the largest Vologda merchant of the 17th century and a consolidated publication of documentary materials related to his trading and official activities. It summarizes almost twenty years of work of the author, Doctor of Historical Sciences, prominent Russian medievalist Marina S. Cherkasova.
Jakob von Gunten - Kritische Edition der Erstausgabe
Authors: Walser Robert 
Published: March 2023

Der Band dokumentiert Robert Walsers dritten Roman Jakob von Gunten. Ein Tagebuch in der Textgestalt des Erstdrucks, der 1909 im Verlag von Bruno Cassirer in Berlin erschienen ist. Er zählt neben Musils Die Verwirrungen des Zöglings Törleß und Hesses Unterm Rad zu den klassischen Werken der Internatsliteratur. Zur Entstehungsgeschichte gibt es kaum Informationen, doch gegenüber Carl Seelig hielt Walser fest, dieser Roman sei ihm unter «seinen umfangreicheren Büchern das liebste».
Das Editorische Nachwort beschreibt die Publikationsgeschichte und die sehr gegensätzliche Aufnahme bei der zeitgenössischen Literaturkritik. Verglichen die einen den Eindruck der Lektüre mit dem «Genuss einer Brauselimonade», fanden andere das Buch «krampfartig eigenartig und zum Sterben langweilig». Gar nicht langweilig fand es Franz Kafka, der im Mai 1910 sein zerlesenes Exemplar dem Freund Max Brod zum Geburtstag verehrte.
Er sei sich «vorläufig noch ein Rätsel», notiert der Held zu Beginn in sein Tagebuch. «Vielleicht steckt ein ganz, ganz gemeiner Mensch in mir. Vielleicht aber besitze ich aristokratische Adern. Ich weiß es nicht. Aber das Eine weiß ich bestimmt: Ich werde eine reizende, kugelrunde Null im späteren Leben sein.»
http://kritische-walser-ausgabe.ch
Sintesis Nanokomposit TiO2-Grafit untuk Degradasi Asap Rokok
Authors: Anggini Aulia , Muldarisnur Mulda 
Published: March 2023

Nanopartikel TiO2 dan nanokomposit TiO2 â€“ Grafit telah berhasil disintesis dengan metode pemanasan sederhana dalam larutan polimer yang diaplikasikan untuk mengukur waktu degradasi senyawa berbahaya yang terkandung pada asap rokok menggunakan cahaya tampak. Polimer yang digunakan adalah PEG 6000. Sintesis dilakukan pada suhu 600Â° C dengan waktu tahan selama 0 jam, 0,5 jam, dan 1 jam. Hasil karakterisasi XRD dan UV Vis DRSÂ menunjukkan ukuran kristal yang terbentuk sebesar 26,5 nm dan besar energi celah pita sebesar 2,98 eV, 2,95 eV, 3,07 eV, dan 3,9 eV untuk TiO2 tanpawaktu tahan, TiO2 â€“ G dengan waktu tahan 0 jam, 0,5 jam, dan 1 jam. Peningkatan waktu tahan menghasilkan kristal yang lebih stabil dan memiliki derajat kristalinitas yang lebih tinggi. Nanokomposit TiO2 â€“ G mampu mendegradasi asap rokok lebih cepat dibandingkan TiO2 tanpa grafit dikarenakan penambahan grafit meningkatkan kemampuan penyerapan cahaya TiO2 di wilayah cahaya tampak. Hal ini menunjukkan nanokomposit TiO2 â€“ G lebih efisien dalam mendegradasi asap rokok dibandingkan nanopartikel TiO2 tanpaGrafit.