bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigating Fatigue and Its Relationship to Quality of Life and Pruritus in Cutaneous T-Cell Lymphoma
Authors: Özistanbullu Deniz , Hackenberg Stephan , Kleemann Johannes , Kippenberger Stefan , Lenders Daniela , Tratzmiller Sabine , Kaufmann Roland , Klemke Claus-Detlev , Meissner Markus , Jäger Manuel 
Published: August 2023

Cancer-related fatigue as a morbid state of physical, emotional, and mental exhaustion influencing everyday life is an important yet poorly investigated symptom in patients with cutaneous T-cell lymphomas. The aim of this study was to evaluate the prevalence of and the association between pruritus, quality of life, and fatigue in patients with cutaneous T-cell lymphomas. Mycosis fungoides and Sézary syndrome patients were invited to complete the Functional Assessment of Cancer Therapy-General (FACT-G) and the Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-Fatigue) subscale questionnaire. Pruritus was assessed using the peak pruritus numeric rating scale. Half of the 38 recruited patients reported fatigue. 13 patients (34%) suffered from severe fatigue. The median (interquartile range) FACIT-Fatigue subscale score was 35.5 (25.75–43). The advanced disease stage was associated with more severe fatigue and a poorer quality of life. The FACIT-Fatigue subscale score was significantly correlated with quality of life (r = 0.8 and

P

< 0.0001). More than 80% of patients reported pruritus. There was no correlation between pruritus and fatigue (r = −0.19 and

P

= 0.26). All in all, fatigue is a common symptom of cutaneous T-cell lymphomas in early and advanced stage disease and has a strongly negative effect on cutaneous T-cell lymphoma patients’ quality of life.
Efforts to Grow Genomic Research in Ancestrally Diverse and Admixed Populations
Authors: Schmit Stephanie L. , Purrington Kristen , Figueiredo Jane C. 
Published: August 2023

Abstract
Recent initiatives by the research community to characterize the genomic and molecular landscapes of tumors in ancestrally diverse and admixed populations, including the publication by Ding and colleagues in this issue of Cancer Research, represent important efforts to improve our understanding of the entire spectrum of cancer genomic variation with potential clinical consequences. Ding and colleagues confirmed a similar prevalence of mutations in established breast cancer driver genes including PIK3CA, TP53, GATA3, MAP3K1, CDH1, CBFB, PTEN, and RUNX1 and recurrent amplifications in breast cancer drivers including MYC, FGFR1, CCND1, and ERBB2 in tumors from Hispanic/Latina women as compared with non-Hispanic White women. Importantly, they also identified Catalogue of Somatic Mutations in Cancer (COSMIC) signature 16 in a significant fraction of tumors from Hispanic/Latina women and a novel recurrent amplification on 17q11.2. This study highlights the potential for inclusion of participants from diverse populations to accelerate discoveries and advance equity in genomic medicine, as well as the need for even larger collaborative initiatives.
See related article by Ding et al., p. 2600
Turning Down the Temperature on Leukemia Stem Cells
Authors: Jones Courtney L. 
Published: August 2023

AbstractOxidative phosphorylation (OXPHOS) is a well-documented dependency of leukemia stem cells (LSC). In this issue of Cancer Research, Griessinger and colleagues have identified cold sensitivity as a new vulnerability of OXPHOS-dependent LSCs. Mechanistically, cold sensitive leukemic cell death is caused by membrane permeabilization due to OXPHOS-dependent differences in membrane lipid species abundance. This work sheds new light onto the contribution of OXPHOS to lipid homeostasis in LSCs and has important implications for the handling and processing of primary acute myeloid leukemia specimens.See related article by Griessinger et al., p. 2461
Risk of Frailty in Survivors of Childhood Cancer: The Role of Socioenvironmental Factors
Authors: Bhandari Rusha , Armenian Saro H. 
Published: August 2023

Abstract
The identification of frailty among relatively young survivors of childhood cancer has led to a growing body of work aimed at examining potential risk factors and interventions to decrease its burden in this population. In the accompanying article, Schwartz and colleagues present their findings regarding the association between neighborhood characteristics and frailty in survivors of childhood cancer and show that survivors living in resource poor neighborhoods had increased odds of frailty compared with those in resource-rich neighborhoods. This work further supports the need for focused educational initiatives and nutrition and exercise interventions to improve survivors’ quality of health.
See related article by Schwartz et al., p. 1021
Axicabtagene Ciloleucel in Combination with the 4–1BB Agonist Utomilumab in Patients with Relapsed/Refractory Large B-Cell Lymphoma: Phase 1 Results from ZUMA-11
Authors: Jain Michael D. , Miklos David B. , Jacobson Caron A. , Timmerman John M. , Sun Jennifer , Nater Jenny , Fang Xiang , Patel Ankit , Davis Madison , Heeke Darren , Trinh Tan , Mattie Mike , Neumann Frank , Kim Jenny J. , To Christina , Filosto Simone , Reshef Ran 
Published: August 2023

Abstract

Purpose:
Chimeric antigen receptor (CAR) T-cell therapies have shown clinical benefit for patients with relapsed/refractory (R/R) large B-cell lymphoma (LBCL), yet approximately 60% of patients do not respond or eventually relapse. We investigated the safety and feasibility of the CD19-directed CAR T-cell therapy axicabtagene ciloleucel (axi-cel) in combination with the 4–1BB agonist antibody utomilumab as an approach to improve efficacy of CAR T-cell therapy.

Patients and Methods:
In phase 1 of the single-arm ZUMA-11 trial, patients with R/R LBCL received a single axi-cel infusion (target dose, 2 × 106 cells/kg) plus utomilumab 10 to 200 mg intravenously every 4 weeks for up to 6 months in a dose-escalation design. The primary endpoint was incidence of dose-limiting toxicities (DLT) with utomilumab. Key secondary endpoints were safety, antitumor activity, pharmacokinetics, and pharmacodynamics.

Results:
No DLTs were observed among patients treated with axi-cel and utomilumab (n = 12). Grade ≥3 adverse events occurred in 10 patients (83%); none were Grade ≥3 cytokine release syndrome or neurologic events. The objective response rate was 75% and seven patients (58%) had a complete response. Peak CAR T-cell levels increased in a utomilumab dose-dependent manner up to 100 mg. Patients who received utomilumab 100 mg had persistently increased CAR T cells on days 57 to 168 compared with other dose levels. Utomilumab was associated with dose-dependent increases in IL2, IFNγ, and IL10.

Conclusions:
Utomilumab-mediated 4–1BB agonism combined with axi-cel therapy had a manageable safety profile. Dual 4–1BB and CD28 costimulation is a feasible therapeutic approach that may enhance CAR T-cell expansion in patients with LBCL.
Kaldor e Prebisch: reflexões sobre a industrialização e as economias de Brasil e Argentina
Authors: Thainan Francisco 
Published: August 2023

O presente artigo abordará os pensamentos de Nicholas Kaldor e Raúl Prebisch acerca da dinâmica macroeconômica, enfatizando a importância da industrialização, a produção de produtos complexos e a relevância relativa da indústria para elevar os níveis de crescimento e redução do dreno atual de recursos na relação centro-periferia, trazendo como enfoque as economias de Argentina e Brasil. Para a execução deste trabalho, será feita uma revisão bibliográfica dos textos originais dos autores bem como de textos relevantes para a compreensão teórica do seu pensamento. Também se recorrerá a obras que versem sobre a dinâmica industrial dos dois países e seus respectivos dados empíricos sobre o tema. O desenvolvimento do trabalho permite a conclusão da relevância da construção teórica de ambos os autores na interpretação de problemas e determinantes para o crescimento das economias da Argentina e do Brasil.
Medical Management Versus Endovascular Treatment for Large-Vessel Occlusion Anterior Circulation Stroke With Low NIHSS
Authors: Safouris Apostolos , Palaiodimou Lina , Nardai Sándor , Kargiotis Odysseas , Magoufis George , Psychogios Klearchos , Matusevicius Marius , Feil Katharina , Ahmed Niaz , Kellert Lars , Spiliopoulos Stavros , Brountzos Elias , Szikora István , Sarraj Amrou , Goyal Nitin , Aguiar de Sousa Diana , Strbian Daniel , Caso Valeria , Alexandrov Andrei V. , Tsivgoulis Georgios 
Published: August 2023

BACKGROUND:
Endovascular treatment (EVT) for acute ischemic stroke (AIS) patients presenting with National Institutes of Health Stroke Scale score of 0 to 5 is common in clinical practice but has not yet been proven safe and effective. Our objective is to assess whether EVT on top of best medical treatment (BMT) in AIS patients with large-vessel occlusion of the anterior circulation presenting with mild symptoms is beneficial compared with BMT.

METHODS:
We searched MEDLINE, SCOPUS, and reference lists of retrieved articles published until December 28, 2022. A systematic literature search was conducted to identify clinical trials or observational cohort studies evaluating patients with AIS due to anterior circulation large-vessel occlusion and admission National Institutes of Health Stroke Scale score ≤5 treated with EVT versus BMT alone. The primary outcome was excellent functional outcome (modified Rankin Scale score 0–1) at 3 months. The protocol had been registered before data collection (PROSPERO).

RESULTS:
Eleven observational eligible studies were included in the meta-analysis, comprising a total of 2019 AIS patients with National Institutes of Health Stroke Scale score ≤5 treated with EVT versus 3171 patients treated with BMT. EVT was not associated with excellent functional outcome (risk ratio, 1.10 [95% CI, 0.93–1.31]). When stratified for different study design (per-protocol versus intention-to-treat), there were no significant subgroup differences. EVT was not associated with good functional outcome (modified Rankin Scale score 0–2; risk ratio, 1.01 [95% CI, 0.89–1.16]) or reduced disability at 3 months (common odds ratio, 0.92 [95% CI, 0.60–1.41]). Symptomatic intracranial hemorrhage was more common in the patients receiving EVT (risk ratio, 3.53 [95% CI, 2.35–5.31]). No correlation was found between EVT and mortality at 3 months (risk ratio, 1.34 [95% CI, 0.83–2.18]). The same overall associations were confirmed in the sensitivity analysis of studies that performed propensity score matching.

CONCLUSIONS:
EVT appears equivalent to BMT for patients with anterior circulation large-vessel occlusion AIS with low baseline National Institutes of Health Stroke Scale, despite the increased risk for symptomatic intracranial hemorrhage.

REGISTRATION:

URL:
https://www.crd.york.ac.uk/PROSPERO/
; Unique identifier: CRD42022334417.
Abū Manṣūr al-Ṯaʿālibī’s Ḫaṣāʾiṣ al-buldān: A Study of an adīb’s Geography, Stereotypes and Lists
Authors: Paredi Riccardo 
Published: August 2023

Abstract
This article focuses on al-Ṯaʿālibī’s (d. 429/1038) works and excerpts of his works dealing with ḫaṣāʾiṣ al-buldān, i.e. specificities of lands and cities. In the first part, I present al-Ṯaʿālibī’s numerous excerpts on ḫaṣāʾiṣ, and discuss the work entitled Ḫaṣāʾiṣ al-buldān, its textual history and attribution to al-Ṯaʿālibī. I then sketch al-Ṯaʿālibī’s travels, firsthand and secondhand geographical knowledge, and sources in order to analyse the contents and form of his ḫaṣāʾiṣ. The textual investigation aims at showing al-Ṯaʿālibī’s usage of common adab features such as intertextuality, lexicographical items and lists to support specific claims of his writing and to reinforce a certain representation of the world based on adab stereotypes and clichés.
3. Business Models and Digitisation
Authors: Cöster Mathias , Danielson Mats , Ekenberg Love , Gullberg Cecilia , Titlestad Gard , Westelius Alf , Wettergren Gunnar 
Published: August 2023

Whilst digitisation is far from a new concept, many assume that simply introducing automation and information systems in various forms will be enough to make their organisation’s operations more efficient. This misconception can often lead to disarray and costly mistakes. Digital Transformation: Understanding Business Goals, Risks, Processes, and Decisions shows how to avoid such issues via careful consideration of what an enterprise really needs.
Unlike many other books on digital transformation, the authors do not dwell on database design or the details of implementing information systems. Instead, they emphasise the importance of a clear understanding of all aspects of an organisation in order to effectively implement and manage digital systems, from business goals and strategies to structuring information and making decisions, risk assessments, project management, organising, and procuring services and products.
Organised in eleven chapters, and drawing on examples from all over the world, this book will be of interest to university students of business administration, management, information systems, and computer science, as well as practitioners seeking to better understand how to handle digital transformation in their own organisation.
Geoffrey Kingdon Fry and the British road to public sector reform
Authors: Page Edward C 
Published: August 2023

To mark the 2023 death of GK Fry this note focuses attention on the approach to public sector reform in Britain discussed in his many works. Starting with his criticism of the 1968 Fulton Committee Report, his work developed a view of reform that foreshadowed debates that later went under the label of ‘new public management’ by at least 20 years. This note explains how he argued that a ‘positive state’ or Fabian approach dominated thinking about public administration for so long and largely accounted for the failure of most of the reforms of the postwar period until the 1980s. Fry’s background and interests to some degree help explain how he reached this perspective and how he set it out, so this note begins and ends with some outline of his life, career and outlook.
Poster 167: Increased Throwing Velocity is Correlated with a Higher Likelihood of Violating Current Pitch Count Recommendations in High School Baseball Pitchers.
Authors: Bowman Eric , Erickson Brandon , Camp Christopher , Freehill Michael , Smith Matthew , Serio Nicholas , Ishikawa Hiroaki , Smith Karch , Chalmers Peter 
Published: August 2023

Objectives: While pitch count and rest guidelines have been promoted for youth and adolescent baseball players for nearly two decades, compliance with guidelines remains poorly understood. The purpose of this study was to determine the frequency of compliance with Pitch Smart guidelines, as well as the association between compliance and range of motion, strength, velocity, injury, and pitcher utilization. Methods: This study was a prospective, multi-center study of high school pitchers, encompassing each region of the United States. Pre-season pitchers were surveyed about their compliance with current off- season rest-related guidelines and history of injury. Pre-season, pitchers underwent standardized physical examinations and pitch velocity was measured. During the high school season that followed, both pitch counts and injury incidence were collected. Results: One hundred and fifteen pitchers participated. Based upon pre-season data, 84% of pitchers had previously violated current pitch recommendation guidelines. During the season, 14% had at least one instance of a violation of the current pitch counts guidelines. Across both the pre-season survey and in-season pitch counts, 89% of players had at least one violation of the current Pitch Smart guidelines. While there were no significant differences in range of motion or strength, those pitchers who were non-compliant with guidelines in the pre-season had higher max pitch velocity (mean±standard deviation 74±8 miles per hour vs. 69±5 miles per hour, p=0.009). Pitchers self-reported their peak velocity at 7 MPH greater than the actual measured velocity. Only a single injury occurred during the season, precluding a comparison between groups. There were no significant differences in the incidence of a history of injury between those pitchers who were noncompliant with between-season rest guidelines (p=0.285). Conclusions: Most high school pitchers are non-compliant with current Pitch Smart guidelines, and they tend to overestimate their peak velocity by 7 MPH. Pitchers with greater velocity were at the highest risk for violating current pitch count recommendations. Since both increased throwing volume and pitch velocity are known risk factors for injury, these athletes may be at particular risk for subsequent injury. research is necessary to understand whether taking three consecutive month rest between seasons prevents pitching-related injury.
Poster 258: Clinical and social predictors of surgical treatment for ACL injuries
Authors: Hubbell Harrison , McCleary Nadine Jackson , Orav Endel John , Tanaka Miho 
Published: August 2023

Objectives: Anterior cruciate ligament (ACL) injuries are one of the most common knee injuries sustained during sports, and over 250,000 ACL reconstructions are performed per year. While surgery is often indicated for younger patients, surgical indications in the adult patient are determined based on patient preference, level of functional disability and their desire to return to cutting and pivoting sports. The purpose of this study was to report on the clinical and social predictors of patients undergoing surgical vs nonsurgical treatment for ACL injury, and to compare differences between males and females. Methods: Patient who were evaluated for ACL injury at our institution were identified and those who subsequently underwent surgery were compared to those who did not. Clinical factors collected included sex, age, BMI, Charlson Comorbidity Index (CCI) and smoking status, while social factors collected included race, English-speaking, educational level, insurance type, and marital status. Functional disability was determined by preoperative PROMs scores based on KOOS-PS and PROMIS PF. Descriptive statistics were used to report on the surgical and nonsurgical cohorts with subgroup analysis by sex. Odds ratios were calculated to determine predictors of surgery, with a subgroup analysis of patients over 30 years of age. Multivariate analysis was performed to determine the relationships between clinical and social factors and KOOS-PS and PROMIS PF scores. Results: 3656 patients were included in this study. 1734 females (mean age 34.7y) and 1922 males (mean age 32.8y) were identified with a diagnosis of ACL tear, of whom 53.8% of females and 53.4% of males went on to surgery (p=0.84). KOOS PS and PROMIS PS did not show a relationship with future surgical intervention, although they were lower in females, those with increased BMI, and lower educational levels. In all patients, CCI (OR 0.867, p<0.001) and current smoking status (OR 0.70, p=0.06) were associated with lower rates of surgical treatment, as were Medicare status (OR 0.54, p=0.04) and having subsidized insurance (OR 0.47, p<0.001). In patients over the age of 30, females were more likely than males to undergo surgical treatment (OR 1.36, p=0.04), while CCI (OR 0.89, p=0.07), current smoking status (OR 0.43, p=0.06) and subsidized insurance (OR 0.60, p=0.06) negatively affected rates of surgery in this group. Conclusions: In our cohort, comorbidity index, smoking status and insurance status were found to negatively influence surgical treatment of ACL injury. In patients aged >30y, females were more likely to undergo surgical treatment than males. Additionally, our study identified lower PROMs scores associated with ACL injury in females, those with increased BMI, and lower educational levels. Further studies are needed to understand the social and clinical factors that can influence variability in functional disability and decisions to proceed with surgical treatment in patients with ACL injuries.
Poster 268: The Relation Between Posterior Tibial Slope Angle and Bilateral ACL Tear
Authors: Li Zachary , Triana Jairo , Rao Naina , buldo-licciardi michael , Rynecki Nicole , Lomas Guillem Gonzalez- , Jazrawi Laith , Garra Sharif 
Published: August 2023

Objectives: Increased posterior tibial slope (PTS) is a risk factor for primary anterior cruciate ligament (ACL) tear, as well as subsequent ACL graft tear. Prior literature has shown conflicting relationships between an increased PTS and bilateral ACL tears. The purpose of this study is to compare PTS angles for patients who had bilateral ACL tears to those who had only sustained a unilateral ACL tear. Methods: Retrospectively we identified patients who had bilateral and unilateral ACL tears at our institution over the last 10 years. Those who had bilateral surgery were matched to those who had unilateral surgery on a ratio of 1:1 based on age, sex, and BMI. Patients with unilateral ACL reconstruction were excluded if they had subsequent revisions or were less than 5 years post-operative. Lateral knee radiographs were used to measure the posterior tibial slope. The tibial axis was found using the circles measurement method which consisted of drawing circles along the tibial shaft and placing a line through the center of each to estimate the anatomical tibial axis. The PTS was then defined as the angle between the perpendicular line to this axis and the tibial plateau tangent line. Three blinded orthopedic residents performed these measurements. In addition to comparison of mean PTS between cohorts, both cohorts were stratified into “high slope” and “low slope” using 10-degress of PTS as a cutoff. An interclass correlation coefficient (ICC) was then calculated. Results: Fifty-three patients with bilateral ACL tears were successfully matched to 53 patients with unilateral tears. The average PTS in patients with bilateral ACL tears was found to be significantly higher than patients with unilateral ACL tears (11.17 vs. 9.72, p = 0.005). An intraclass correlation coefficient was calculated to 0.80 (95% confidence interval: 0.75 – 0.85). These cohorts were then stratified by the aforementioned sub-groups, finding that 69.8% of the bilateral cohort had more than 10-degrees of PTS, while this was true for only 46.4% of the unilateral cohort (p = 0.006). Conclusions: These results demonstrate that patients with bilateral ACL tears have higher PTS angles than those who only had unilateral ACL tear. Clinicians should consider routinely assessing PTS in a newly-presenting patient with an initial ACL tear, as marked deviations from the general population could be a predisposing risk factor for subsequent contralateral tear. Further prospective research is necessary to determine if patients with unilateral ACL tears who present with this radiographic finding are at greater risk for contralateral tear.