bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of a multi-professional intervention on body composition, physical fitness and biochemical markers in overweight COVID-19 survivors: a clinical trial
Authors: Sordi Ana Flávia , Lemos Maurício Medeiros , de Souza Marques Déborah Cristina , Ryal Joed Jacinto , Priscila de Paula Silva Lalucci Marielle , Marques Marilene Guiraldi , Amaro Camilo Maria Luiza , De Paula Ramos Solange , Franzói De Moraes Solange Marta , Valdés-Badilla Pablo , Mota Jorge , Magnani Branco Braulio Henrique 
Published: August 2023

Introduction: The sequelae post-COVID can affect different systems. In this sense, considering the multi-factorial etiology of COVID-19, multi-professional interventions could be a relevant strategy for recovery health indicators.Objective: This study aimed to investigate the effects of multi-professional intervention on body composition, physical fitness, and biomarkers in overweight COVID-19 survivors with different symptomatology.Methodology: A non-randomized parallel group intervention included 69 volunteers (BMI ≥25 kg/m2), divided into three groups according to SARS CoV-2 symptomatology, but only 35 finished the longitudinal protocol [control group (n = 11); moderate group (n = 17) and severe group (n = 7)]. The groups were submitted to a multi-professional program (nutritional intervention, psychoeducation, and physical exercise intervention) for 8 weeks, and the volunteers underwent body composition assessments (primary outcome) and physical and biochemical tests (secondary outcome) in pre- and post-intervention. This study was registered on the Clinical Trials Registration Platform number: RBR-4mxg57b and with the local research ethics committee protocol under number: 4,546,726/2021.Results: After the 8-week multi-professional intervention, the following results were observed for the moderate COVID-19 group: improved dynamic strength of lower- and (p = 0.003), upper-limbs (p = 0.008), maximal isometric lumbar-traction strength (p = 0.04), flexibility (p = 0.0006), and albumin (p = 0.0005), as well as a reduction in the C reactive protein (CRP) (p = 0.003) and fasting glucose (p = 0.001); for the severe COVID-19 group: an improvement in dynamic lower-body strength (p = 0.001), higher values of albumin (p = 0.005) and HDL-c (p = 0.002), and lower values of CRP (p = 0.05), and for the control group: an improvement in sit-up repetitions (p = 0.008), and a reduction of CRP (p = 0.01), fasting glucose (p = 0.001) and total cholesterol (p = 0.04) were identified. All experimental groups reduced triglycerides after intervention (p &lt; 0.05).Conclusion: Finally, 8 weeks of multiprofessional intervention can be an efficient tool for reversing the inflammatory process and promoting improvements in daily activities and quality of life, although it is believed that the severe COVID-19 group needs longer interventions to improve different health indicators.Clinical Trial Registration:https://ensaiosclinicos.gov.br/, identifier: RBR-4mxg57b.
Interventions to improve equational reasoning: replication and extension of the Cuisenaire-Gattegno curriculum effect
Authors: Benson Ian , Marriott Nigel , McCandliss Bruce D. 
Published: August 2023

IntroductionThe ability to reason about equations in a robust and fluent way requires both instrumental knowledge of symbolic forms, syntax, and operations, as well as relational knowledge of how such formalisms map to meaningful relationships captured within mental models. A recent systematic review of studies contrasting the Cuisenaire-Gattegno (Cui) curriculum approach vs. traditional rote schooling on equational reasoning has demonstrated the positive efficacy of pedagogies that focus on integrating these two forms of knowledge.MethodsHere we seek to replicate and extend the most efficacious of these studies (Brownell) by implementing the curriculum to a high degree of fidelity, as well as capturing longitudinal changes within learners via a novel tablet-based assessment of accuracy and fluency with equational reasoning. We examined arithmetic fluency as a function of relational reasoning to equate initial performance across diverse groups and to track changes over four growth assessment points.ResultsResults showed that the intervention condition that stressed relational reasoning leads to advances in fluency for addition and subtraction with small numbers. We also showed that this intervention leads to changes in problem solving dispositions toward complex challenges, wherein students in the CUI intervention were more inclined to solve challenging problems relative to those in the control who gave up significantly earlier on multi-step problems. This shift in disposition was associated with higher accuracy on complex equational reasoning problems. A treatment by aptitude interaction emerged for both arithmetic equation reasoning and complex multi-step equational reasoning problems, both of which showed that the intervention had greatest impact for children with lower initial mathematical aptitude. Two years of intervention contrast revealed a large effect (d = 1) for improvements in equational reasoning for the experimental (CUI) group relative to control.DiscussionThe strong replication and extension findings substantiate the importance of embedding these teaching aides within the theory grounded curricula that gave rise to them.
Predictors of mental well-being over the first lockdown period due to the COVID-19 pandemic in France. A repeated cross-sectional study
Authors: Barbalat Guillaume , Tanguy Melac Audrey , Zante Elodie , Haesebaert Frédéric , Franck Nicolas 
Published: August 2023

IntroductionNumerous studies have investigated the positive and negative effects of potential predictors of well-being during lockdowns due to COVID-19. Yet, little is known on whether these effects significantly changed with time spent in lockdown. In the current study, we described the association of mental well-being with a large number of background characteristics (e.g., socio-demographic or health-related factors), COVID-related factors, and coping strategies, over the duration of the first lockdown due to COVID-19 in France.MethodsA nationwide online survey was conducted over 7 of the 8 weeks of the 1st lockdown in France, i.e., from 25 March 2020 to 10 May 2020. The level of mental well-being was reported using the Warwick-Edinburgh Mental Well-Being Scale (WEMWBS). We also measured various background characteristics (e.g., age, sex, education, health issues), COVID-related factors (e.g., health and economic risks, agreement with lockdown), and coping strategies. Our analytical strategy enabled us to disentangle effects aggregated over the study period from those that linearly vary with time spent in lockdown.ResultsOur final dataset included 18,957 participants. The level of mental well-being dropped gradually from the third to the eighth week of lockdown [49.7 (sd 7.9) to 45.5 (sd 10.6)]. Time in lockdown was associated with a decrease in well-being (for each additional 10 days of lockdown: B = −0.30, 95%CI: −0.62, −0.15). Factors that showed significantly negative and positive effects on well-being as time in lockdown progressed were (for each additional 10 days of lockdown): having current psychiatric problems (B = −0.37; 95%CI: −0.63, −0.04), worries about having access to personal protective equipment (B = −0.09; 95%CI: −0.18, −0.01), coping by having positive beliefs about the future of the pandemics (B = 0.29; 95%CI: 0.04, 0.62), being supported by neighbors (B = 0.24; 95%CI: 0.04, 0.44), and being involved in collective actions (B = 0.23; 95%CI: 0.04, 0.46).DiscussionParticipants from our sample saw a drop in their mental well-being throughout the first period of COVID-19 lockdown. Policymakers should be mindful of factors contributing to greater deterioration of mental well-being over time, such as having current psychiatric issues. Promoting collective actions and local support from neighbors may alleviate the deterioration of mental well-being over time.
IDENTIFICATION AND DISTRIBUTION OF THE HH4 FERTILITY HAPLOTYPE OF HOLSTEIN CATTLE IN A SUBPOPULATION OF THE KRASNODAR TERRITORY
Authors: КОВАЛЮК Н.В. , ВОЛЧЕНКО А.Е. , ШИРЯЕВА Е.В. , ЯКУШЕВА Л.И. , ШАХНАЗАРОВА Ю.Ю. 
Published: August 2023

Мутация, связанная с гаплотипом HH4, приводит к замене аденина (A) на цитозин (C) в положении 1277227 (g.1277227A>C) на хромосоме BTA1, что вызывает замену аспарагина на треонин в одном из белков (GART), необходимых для биосинтеза таких важных молекул, как ДНК, РНК, АТФ. Потеря функции GART вызывает гибель эмбрионов на самых ранних стадиях после оплодотворения. Нами разработана тест-система для идентификации животных — носителей гаплотипа НН4 — на основе методов ПЦР/ПДРФ. В статье приведены последовательности праймеров, условия ПЦР-реакции, указаны необходимая эндонуклеаза и условия рестрикции. С использованием контрольного образца проведены апробация разработанной тест-системы и генотипирование выборки (n=130) образцов крови коров и телок из 3 хозяйств Краснодарского края и спермы быков-производителей, принадлежащих двум племенным предприятиям. Установлено, что частота встречаемости носителей гаплотипа в протестированной выборке животных (2023 год) составила 1,5%.
The mutation associated with the haplotype HH4 leads to the replacement of adenine (A) with cytosine (C) at position 1277227 (g.1277227A>C) on the BTA1 chromosome, which causes the replacement of asparagine with threonine in one of the proteins (GART) necessary for the biosynthesis of such important molecules as DNA, RNA, ATF. Loss of GART function causes the death of embryos at the earliest stages after fertilization. We have developed a test system for the identification of haplotype HH4 carrier animals based on PCR/PDRF methods. The article presents the sequences of primers, the conditions of the PCR reaction, the necessary endonuclease and restriction conditions. With the use of a control sample, the developed test system was tested and a sample (n=130) of blood samples of cows and heifers from 3 farms of the Krasnodar Territory and sperm of bulls belonging to two breeding enterprises was genotyped. It was found that the frequency of occurrence of haplotype carriers in the tested sample of animals was 1.5%.
FLAXSEED FEED SUPPLEMENT FOR COWS
Authors: МИЛУШЕВ Р.К. , ШУЛАЕВ Г.М. , ДОРОВСКИХ В.И. , ЖАРИКОВ В.С. 
Published: August 2023

Разработан состав кормовой добавки «Омегален» из льняного семени, кукурузы и биологически активных веществ (биоплексы йода и селена, витамин Е). Она представляет собой комбинацию синергически взаимодействующих компонентов, которые могут влиять на обмен веществ и продуктивность животных. Все компоненты находятся в органической форме и легко усваиваются организмом. Эффективность применения добавки исследована на коровах голштинской породы с удоем 8,5 тыс. кг за лактацию. Установлено, что применение ее в их рационе в количестве 0,75 кг на 1 голову в сутки в период раздоя улучшает обмен веществ: количество гемоглобина увеличилось на 4%, активность фермента гамма-глутамилтранспептидазы повысилась на 7 ед/л (P<0,05), молочная продуктивность выросла на 16,4%. Использование кормовой добавки в течение 58 дней было экономически оправдано, дало дополнительный доход на 1 корову 4461 руб. за счет увеличения продуктивности.
The composition of a feed additive made of flaxseed, corn and biologically active substances (iodine and selenium bioplexes, vitamin E) has been developed. It is a combination of synergistically interacting components that can influence the metabolism and productivity of animals. All components are in organic form and are easily absorbed by the body. The effectiveness of the additive was studied on Holstein cows with milk yield of 8.5 thousand kg per lactation. It was found that its use in their diet in the amount of 0.75 kg per 1 head per day during the period of milking improves metabolism: the amount of hemoglobin increased by 4%, the activity of the enzyme gamma-glutamyltranspeptidase increased by 7 units/l (P<0.05), milk productivity increased by 16.4%. The use of feed additive for 58 days was economically justified, gave additional income per 1 cow 4461 rubles due to increased productivity.
El desarrollo psicomotor en niños menores de 5 años con cardiopatía congénita, Madre de Dios-Perú
Authors: Quispe Layme Wilian , Quispe Aquise Jhemy , Cuse Quispe Jaime , Quispe Layme Marleny , Ramos Pillaca Vilma , Ccahuantico Ccasa Yessica 
Published: August 2023

A nivel mundial, la cardiopatía congénita en los niños es la malformación más común que puede tener un bebé al nacer. Objetivo. Analizar el comportamiento del desarrollo psicomotor de los niños menores a 5 años con cardiopatía congénita en la región de Madre de Dios, Perú. Materiales y métodos. Se consideró un enfoque cuantitativo, de tipo observacional analítica con diseño de cohorte prospectivo, con muestreo no probabilístico y una muestra de 6 infantes a quienes se aplicó el instrumento de recolección de información “observación del desarrollo psicomotor en niños con cardiopatía congénita”. Resultados. El género del paciente varón en promedio es de 33.33%, la edad en promedio de los pacientes con cardiopatía congénita es de 2 años; el tipo de cardiopatía congénita de los pacientes es atresia pulmonar y estenosis aortica, mostrando un desarrollo psicomotor promedio de nivel medio; el tipo de cirugía desarrollado en el paciente en promedio es de tipo definitivo; alcanzando de esta manera una estancia hospitalaria de 16 a 30 días en promedio y alcanzando un estado nutricional promedio de desnutrición severa. Además, la relación entre el tipo de cardiopatía congénita con el desarrollo psicomotor es positiva, toda vez que, ante un incremento del desarrollo psicomotor de los pacientes, entonces los casos de cardiopatía congénita incrementan (? de Pearson =0.6919). Conclusiones. Se determinó que, en los pacientes estudiados el desarrollo psicomotor es de nivel medio; la misma que está relacionado por el tipo de cardiopatía congénita que tiene, donde el 33.33% de los pacientes presentan atresia pulmonar y el 16.67% tiene estenosis aortica; lo que demuestra que la relación entre el tipo de cardiopatía congénita con el desarrollo psicomotor es positiva o directa.
Propagación y prevención del dengue en la amazonia: Oportuna intervención en salud desde la educación
Authors: Maraza Vilcanqui Beker , Maraza Vilcanqui Nain , Flores Choque Gladys Martha , Maraza Vilcanqui Queke 
Published: August 2023

La salud de la población selvática está en riesgo por la presencia del mosquito de la especie Aedes aegypti. Objetivo. Determinar el control de propagación y formas de prevención del dengue que afecta la salud de los pobladores de la región amazónica peruana. Materiales y métodos. Se realizó un estudio mixto, de carácter descriptivo fenomenológicos sobre la presencia del mosquito transmisor del dengue, la población estuvo constituida tres mil pobladores que viven alrededor de la laguna Yarinacocha en el distrito de Yarinacocha provincia de Coronel Portillo de la ciudad de Pucallpa, constando con una muestra representativa de veintidós familias a conveniencia del investigador y que pertenecen en calidad de estudiante de la Universidad Nacional Intercultural de la Amazonía. Se aplicó la observación y entrevista como técnica, además sus instrumentos como la ficha de observación y ficha de entrevista permitió identificar su conocimiento, tratamiento y prevención del dengue. Resultados. La mayoría de los pobladores conocen la forma de propagación, tratamiento y los cuidados de esta plaga que existe en la Amazonía, en consecuencia, el dengue es una enfermedad que afecta la salud de la población de la selva peruana, la detección y la intervención tardía en los pacientes complica la vida, por ello, optan a diversas alternativas para su tratamiento, prevención y para no propagación se utiliza conocimientos ancestrales y científicas. Conclusiones. El dengue es una enfermedad que se propaga rápidamente en las regiones donde hay presencia de zancudo, su complicación puede terminar en un derrame y fallecimiento en los pacientes de alto riesgo
Le bois dans les constructions de la ville médiévale : les questions
Authors: Pesez Jean-Marie 
Published: August 2023

Uses of wood in construction are numerous and varied : for framework walls, partitions, roofing, flooring, window openings, plinths, wall coverings, and also enclosures, roads, somtimes ramparts, and in ports, for pontoons and quais.
Even in countries where construction was done exclusively with stone, wood was necessary for the skeletal structure. The carpenter's work seems to have made progress in the Middle Ages, bvt this progress came perhaps rather late. The triangulated form was not put to use until the very end of the Middle Ages. Dendochronology should allow us to verify this assertion.
The place of wood in domestic constructions also brings up certain questions. Wood is the material of preference in Slavic villages, at least in the forestry zones of Northern Europe. However, in the mediterranean region, texts up to the 13th C. only mention material if stone is used and then only if wood is used. Archeology invites us to devote attention to the place of wood in the 13th C.
In the Western world, proof from the high Middle Ages is not abundant ; when it does exist, it evokes, pole/post armature for houses and wicker-work surfaces. Does stone then later replace wood ? Etoubtless this is true, but wood makes a come-back at the end of the Middle Ages, with the wood panel technique.
Cognitive and Neuropsychological Disorders in Patients with Multiple Sclerosis: A Focus on Verification and Diagnosis of Poorly Recognized Disease Symptoms (A Literature Review)
Authors: Федулов А.С. , Благочинная К.В. , Борисов А.В. 
Published: August 2023

В статье представлена эволюция понимания диагностической и прогностической значимости когнитивных (КН) и нейропсихологических нарушений (НПН) у пациентов с рассеянным склерозом (РС) и обоснование рассмотрения их в качестве самостоятельной составляющей клинического диагноза. Проводится оценка клинических проявлений КН и НПН и вопросов применения различных методов их выявления. Как показывает анализ литературных данных, наиболее частыми, мало распознаваемыми симптомами РС являются когнитивная дисфункция, усталость / повышенная утомляемость и депрессия. Полное нейропсихологическое исследование позволяет с высокой степенью достоверности выявить клинические особенности КН у конкретного пациента, мониторировать их состояние как в случае естественного течения заболевания, так и в условиях применения того или иного варианта (медикаментозная терапия, когнитивная реабилитация) их коррекции. Важным компонентом диагностического процесса является сопоставление клинических и нейровизуализационных данных. Представлены данные о влиянии болезнь-модифицирующей терапии РС на основные проявления КН и НПН, описаны современные технологии когнитивной реабилитации с учетом результатов проведенных доказательных исследований. В качестве иллюстративного материала приводится предварительная оценка собственных когортных исследований КН/НПН в белорусской популяции.
The article presents the evolution of understanding of cognitive impairment (CI) and neuropsychological disorders (NPD) diagnostic and prognostic significance in patients with multiple sclerosis (MS) and substantiates their consideration as an independent component of the clinical diagnosis. Clinical manifestations of CI and NPD are evaluated, and the application of various methods for their detection is discussed. As the analysis of the literature data shows, the most common and poorly recognized symptoms of MS are cognitive dysfunction, fatigue and depression. A complete neuropsychological examination allows identifying with a high degree of reliability clinical features of CI in a particular patient, monitoring their condition both in the case of a natural course of the disease and in conditions of application of one or another option (drug therapy, cognitive rehabilitation) of their correction. Comparing clinical and neuroimaging data constitutes an important component of the diagnostic process. Data on the impact of MS disease- modifying therapy on the main manifestations of CI and NPD are presented, and modern technologies of cognitive rehabilitation are described taking into account the results of evidence-based studies carried out. As illustrative material, a preliminary estimation of own cohort CI/NPD studies in the Belarusian population is presented.
Dystrophic Myotonia: A Literature Review
Authors: Рушкевич Ю.Н. , Мальгина Е.В. , Гусина А.А. , Лихачев С.А. , Ходулев В.И. , Григорович Т.В. , Корбут Т.В. , Брант Е.В. 
Published: August 2023

Дистрофическая миотония – наследственное мультисистемное нервно-мышечное заболевание, основные клинические проявления которого включают не только миотонию и прогрессирующую мышечную дистрофию, но и патологию со стороны других органов и систем. Является наиболее распространенной формой мышечной дистрофии у взрослых. Распространенность дистрофической миотонии широко варьирует в зависимости от возраста, численности населения, континентов, источников данных и критериев диагностики. Характеризуется медленно прогрессирующим течением с высокой частотой инвалидизации у детей и лиц трудоспособного возраста. В настоящей работе представлен обзор литературы с описанием наиболее частых клинических форм дистрофической миотонии, особенностей медико-генетического исследования и дифференциальной диагностики. Также рассматриваются вопросы симптоматического лечения и перспективы патогенетического лечения данного заболевания. Ведение пациентов с дистрофической миотонией требует междисциплинарного подхода к диагностике, наблюдению и симптоматической терапии.
Dystrophic myotonia is a hereditary multisystem neuromuscular disease whose main clinical manifestations include myotonia and progressive muscular dystrophy as well as pathologies of other organs and systems. It is the most common form of muscular dystrophy in adults. The prevalence of myotonia dystrophica varies widely depending on age, population size, continents, data sources, and diagnostic criteria. It is characterized by a slowly progressive course with a high incidence of disability in children and working age individuals. This paper presents a literature review describing most common clinical forms of dystrophic myotonia, features of medical genetic testing and differential diagnosis. The issues of symptomatic treatment and prospects of pathogenetic treatment of this disease are also considered. The management of patients with dystrophic myotonia requires an interdisciplinary approach to diagnosis, observation and symptomatic therapy.
THE EFFECT OF ONLINE CUSTOMER REVIEW COMMUNICATION ON PURCHASE INTEREST WITH TRUST AS INTERVENING IN BUKALAPAK ONLINE STORE IN PADANG CITY
Authors: Martha Zike , Syahriani Bishry Asni Dewi , Defhany  
Published: August 2023

This research is choosing a topic to determine the effect of online customer review communication on purchase interest with trust as an intervening at the Bukalapak online store in the city of Padang. The population in this study were all consumers who shopped online at the Bukalapak online store in Padang City in 2020 whose number was not known with certainty, with a total sample of 138 people. The sampling technique used nonprobability sampling method with accidental sampling technique. The data analysis method used partial least squares (PLS).
The summary of the results obtained from this study shows that online customer reviews have a significant positive effect on consumer trust in the online shop Bukalapak in the city of Padang. Online customer reviews have a significant positive effect on consumer purchase interest at Bukalapak online store in Padang City. Trust has a significant positive effect on consumer purchase interest at Bukalapak online store in Padang City. Then online customer reviews have a significant positive effect on purchase interest through trust in the online shop Bukalapak in the city of Padang.