bluuebunny/crossref_metadata_2025_split huggingface dataset:
High‐Dimensional Chemostratigraphy of Pelagic Clay in the Western North Pacific Ocean Revealed via an Unsupervised Clustering Approach
Authors: Yasukawa Kazutaka , Tanaka Erika , Miyazaki Takashi , Vaglarov Bogdan S. , Chang Qing , Nakamura Kentaro , Ohta Junichiro , Fujinaga Koichiro , Iwamori Hikaru , Kato Yasuhiro 
Published: July 2023

AbstractPelagic clay constitutes massive and apparently uniform lithology that limits the stratigraphic correlation between neighboring sediment core samples. Recent studies on the pelagic clay in the western North Pacific Ocean demonstrated that the bulk chemical composition of sediments constitutes multielemental chemostratigraphy, deducing the correlation between visibly featureless pelagic clay layers across several cores. However, this heuristic approach utilized only a few elements. Therefore, this study employed multivariate statistical techniques, includingk‐means cluster analysis, to analyze the chemical composition data set of 1,646 samples × 41 elements of the western North Pacific pelagic clay. The pelagic clay was classified into 10 clusters systematically aligned from the seafloor to the depth in a specific order, constituting stratigraphic units that reflected the high‐dimensional geochemical features of these 41 elements. This finding strongly supports the statistical robustness of the latent chemostratigraphy in the western North Pacific pelagic clay. Additionally, we performed Sr–Nd–Pb isotope analyses of the detrital silicate fractions of the centroid samples representing each cluster. The multi‐isotopic features of the detrital fraction varied from a mixture of North American and Asian dusts to a predominance of Asian dust superimposed by volcanic inputs. This secular variation in the matrix components is attributable to the northwestward motion of the Pacific Plate and the time‐varying influence of arc volcanism throughout sedimentary history. The proposed integrated approach of multivariate statistical and isotopic analyses effectively extracted the essential information hidden in the pelagic clay, which may postulate a new protocol for paleoceanographic reconstructions targeting the pelagic realm.
Sources, seasonal cycling, and fate of plutonium in a seasonally stratified and radiologically contaminated pond
Authors: Wasserman Naomi L. , Merino Nancy , Coutelot Fanny , Kaplan Daniel I. , Powell Brian A. , Kersting Annie B. , Zavarin Mavrik 
Published: July 2023

AbstractUnlike short-term laboratory experiments, studies at sites historically contaminated with radionuclides can provide insight into contaminant migration behavior at environmentally-relevant decadal timescales. One such site is Pond B, a seasonally stratified reservoir within Savannah River Site (SC, USA) has low levels (μBq L−1) of plutonium in the water column. Here, we evaluate the origin of plutonium using high-precision isotope measurements, investigate the impact of water column geochemistry on plutonium cycling during different stratification periods, and re-evaluate long-term mass balance of plutonium in the pond. New isotopic data confirm that reactor-derived plutonium overwhelms input from Northern Hemisphere fallout at this site. Two suggested mechanisms for observed plutonium cycling in the water column include: (1) reductive dissolution of sediment-derived Fe(III)-(oxyhydr)oxides during seasonal stratification and (2) plutonium stabilization complexed strongly to Fe(III)-particulate organic matter (POM) complexes. While plutonium may be mobilized to a limited extent by stratification and reductive dissolution, peak plutonium concentrations are in shallow waters and associated with Fe(III)-POM at the inception of stratification. This suggests that plutonium release from sediments during stratification is not the dominant mechanism driving plutonium cycling in the pond. Importantly, our analysis suggests that the majority is retained in shallow sediments and may become increasingly recalcitrant.
Codelivery of resveratrol melatonin utilizing pH responsive sericin based nanocarriers inhibits the proliferation of breast cancer cell line at the different pH
Authors: Aghaz Faranak , Asadi Zahra , Sajadimajd Soraya , Kashfi Khosrow , Arkan Elham , Rahimi Zohreh 
Published: July 2023

AbstractProtein-based nanocarriers have demonstrated good potential for cancer drug delivery. Silk sericin nano-particle is arguably one of the best in this field. In this study, we developed a surface charge reversal sericin-based nanocarrier to co-deliver resveratrol and melatonin (MR-SNC) to MCF-7 breast cancer cells as combination therapy. MR-SNC was fabricated with various sericin concentrations via flash-nanoprecipitation as a simple and reproducible method without complicated equipment. The nanoparticles were subsequently characterized for their size, charge, morphology and shape by dynamic light scattering (DLS) and scanning electron microscope (SEM). Nanocarriers chemical and conformational analysis were done by fourier transform infrared spectroscopy (FT-IR) and circular dichroism (CD) respectively. In vitro drug release was determined at different pH values (7.45, 6.5 and 6). The cellular uptake and cytotoxicity were studies using breast cancer MCF-7 cells. MR-SNC fabricated with the lowest sericin concentration (0.1%), showed a desirable 127 nm size, with a net negative charge at physiological pH. Sericin structure was preserved entirely in the form of nano-particles. Among the three pH values we applied, the maximum in vitro drug release was at pH 6, 6.5, and 7.4, respectively. This pH dependency showed the charge reversal property of our smart nanocarrier via changing the surface charge from negative to positive in mildly acidic pH, destructing the electrostatic interactions between sericin surface amino acids. Cell viability studies demonstrated the significant toxicity of MR-SNC in MCF-7 cells at all pH values after 48 h, suggesting a synergistic effect of combination therapy with the two antioxidants. The efficient cellular uptake of MR-SNC, DNA fragmentation and chromatin condensation was found at pH 6. Nutshell, our result indicated proficient release of the entrapped drug combination from MR-SNC in an acidic environment leading to cell apoptosis. This work introduces a smart pH-responsive nano-platform for anti-breast cancer drug delivery.
Optimization of neural-network model using a meta-heuristic algorithm for the estimation of dynamic Poisson’s ratio of selected rock types
Authors: Waqas Umer , Ahmed Muhammad Farooq , Rashid Hafiz Muhammad Awais , Al-Atroush Mohamed Ezzat 
Published: July 2023

AbstractThis research focuses on the predictive modeling between rocks' dynamic properties and the optimization of neural network models. For this purpose, the rocks' dynamic properties were measured in terms of quality factor (Q), resonance frequency (FR), acoustic impedance (Z), oscillation decay factor (α), and dynamic Poisson’s ratio (v). Rock samples were tested in both longitudinal and torsion modes. Their ratios were taken to reduce data variability and make them dimensionless for analysis. Results showed that with the increase in excitation frequencies, the stiffness of the rocks got increased because of the plastic deformation of pre-existing cracks and then started to decrease due to the development of new microcracks. After the evaluation of the rocks’ dynamic behavior, the v was estimated by the prediction modeling. Overall, 15 models were developed by using the backpropagation neural network algorithms including feed-forward, cascade-forward, and Elman. Among all models, the feed-forward model with 40 neurons was considered as best one due to its comparatively good performance in the learning and validation phases. The value of the coefficient of determination (R2 = 0.797) for the feed-forward model was found higher than the rest of the models. To further improve its quality, the model was optimized using the meta-heuristic algorithm (i.e. particle swarm optimizer). The optimizer ameliorated its R2 values from 0.797 to 0.954. The outcomes of this study exhibit the effective utilization of a meta-heuristic algorithm to improve model quality that can be used as a reference to solve several problems regarding data modeling, pattern recognition, data classification, etc.
Modeling and experimental investigation of the effect of carbon source on the performance of tubular microbial fuel cell
Authors: Karamzadeh Masoud , Kadivarian Milad , Mahmoodi Peyman , Asefi Seyedeh Sajedeh , Taghipour Amirhossein 
Published: July 2023

AbstractMicrobial fuel cells (MFCs) serve two main purposes: clean energy production and wastewater treatment. This study examines the impact of different carbon sources on MFC performance and develops a mathematical model to replicate the polarization curve. The biological reactor employed three types of carbon sources: glucose as a simple feed, microcrystalline cellulose (MCC), and a slurry of the organic component of municipal solid waste (SOMSW) as complex feeds. The MFCs were operated in both open and closed circuit modes. The maximum open circuit voltages achieved were 695 mV for glucose, 550 mV for MCC, and 520 mV for SOMSW as substrates. The influence of the substrate in closed circuit mode was also investigated, resulting in maximum power densities of 172 mW/m2, 55.5 mW/m2, and 47.9 mW/m2 for glucose, MCC, and SOMSW as substrates, respectively. In the second section, a mathematical model was developed to depict the polarization curve while considering voltage losses, namely activation, ohmic, and concentration loss, with an average relative error (ARE) of less than 10%. The mathematical models demonstrated that the activation loss of voltage increased with the complexity of the substrate and reached its peak value when SOMSW was used as the substrate.
Congenital toxoplasmosis among hospitalized infants in Poland in the years 2007–2021: study based on the national hospital registry
Authors: Rząd Michał , Kanecki Krzysztof , Lewtak Katarzyna , Goryński Paweł , Tyszko Piotr , Lewandowska-Andruszuk Izabela , Nitsch-Osuch Aneta 
Published: July 2023

AbstractCongenital toxoplasmosis (CT) is a rare entity and it may pose a life-threatening risk for the newborns. The aim of the study was to evaluate the incidence and other selected factors of CT in Poland. Our study is a population-based study on CT patients in 2007–2021. The study was based on 1504 hospitalization records of first-time diagnosis of CT in newborns. In the study group, we observed 763 males (50.7%) and 741 females (49.3%). The mean and median age was 31 days and 10 days, respectively. Based on the hospital registry, the mean annual CT incidence was estimated to be 2.6 per 10,000 live births (95% CI 2.0–3.2 per 10,000 live births). The incidence of CT cases fluctuated over the years 2007–2021, with the highest incidence in 2010 and the lowest one in 2014. There were no statistically significant differences between the incidence of CT in relation to sex or place of residence. The periodic fluctuations in the number of cases of congenital toxoplasmosis indicates the need to develop effective prevention programs to effectively counteract the disease and its consequences.
African ancestryAPOEe4 non-carriers with higher educational attainment are resilient to Alzheimer disease pathology-specific blood biomarker pTau181
Authors: Rajabli Farid , Seixas Azizi A. , Akgun Bilcag , Adams Larry D. , Inciute Jovita , Starks Takiyah , Laux Renee , Byrd Goldie S , Haines Jonathan L , Beecham Gary W , Vance Jeffery M , Cuccaro Michael L , Pericak-Vance Margaret A. 
Published: July 2023

ABSTRACTCognitive and functional abilities in individuals with Alzheimer disease (AD) pathology (ADP) show greater than expected variability. While most individuals show substantial impairments in these abilities, a considerable number show little or no impairments. Factors contributing to this variability are not well understood. For instance, multiple studies have shown that higher levels of education are associated with reduced cognitive impairments among those with ADP. However, it remains unclear whether higher levels of education are associated with functional impairments among those with ADP.We studied 410 AA individuals with advanced levels of pTau181 (a biomarker for ADP; individuals as those having log10(pTau181) level greater than one standard deviation above the mean) to determine whether EA (categorized as low EA for individuals with ≤ 8 years of education and high EA for those with >8 years) promotes functional resilience and whether this effect varies between APOE ε4 carriers and non-carriers. We used the four non-memory components of the Clinical Dementia Rating (CDR) to create a composite score (CDR-FUNC) to evaluate functional difficulties (scored from 0=no impairment to 12=severe). We employed the non-parametric Mann-Whitney U test to assess the relationship between EA and CDR-FUNC in advanced levels of pTau181 individuals.The results showed that EA promotes resilience to functional problems in AA individuals with advanced levels of pTau181, such that individuals with high EA are more likely to have better functional ability compared to those with lower EA (W=730.5, p=0.0007). Additionally, we found that the effect of high EA on functional resilience was stronger in ε4 non-carriers compared to ε4 carriers (W=555.5, p=0.022).This study extends the role of cognitive reserve and EA to functional performance showing that cognitive reserve influences the association between ADP burden and functional difficulties. Interestingly, this protective effect seems less pronounced in carriers of the strong genetic risk allele ε4. The results highlight the intricate interplay of genetic and non-genetic factors in AD progression, suggesting a need for more personalized strategies to manage functional decline in AD.
Characterization and contextualization of transgender women population and condom use in the HIV syndemic framework: Scoping review
Authors: Moncayo-Quevedo Jorge Eduardo , Pérez-Arizabaleta María Del Mar , Rodríguez-Ortiz Alejandra Rocio , Villegas-Trujillo Lina María 
Published: July 2023

ObjectiveTo characterize and contextualize condom use in the transgender women (TW) population utilizing the HIV syndemic framework.MethodsStudies reported condom-use frequency and syndemic factors associated with HIV risk in the TW population were searched in databases. We followed the PRISMA Extension for Scoping Reviews checklist.ResultsSocial factors have a proven relationship with using condoms and HIV among TW. Syndemic factors, and how some of them reinforce others, deserve a specific analysis to develop strategies to face HIV among TW.ConclusionsAnalyzing a syndemic perspective allows to generate specific health intervention and prevention policies to protect the TW.
The effectiveness of social norms in promoting green consumption
Authors: Do Van Thi Hong , Do Long Thanh 
Published: July 2023

Purpose
Given the seriousness of environmental issues, academic research has proposed social norms as an effective policy tool to encourage a wide range of pro-environmental behaviors, including green consumption. However, tangible evidence of the effectiveness of the social norm approach for green consumption behaviors is unreconciled, raising controversy about such a strategy. Considering that social norm interventions are only effective when targeted at the right consumers, this study aims to focus on exploring the role of individual difference factors, namely, social power value-, social face value- and independence orientations, in clarifying the effects of social norms on green consumption behaviors.

Design/methodology/approach
The study uses hierarchical ordinary least squares regression to test the hypotheses with survey data from 269 consumers in Southeast Asia.

Findings
The study reveals that perceived social norms positively predict green consumption behaviors, providing additional evidence for the effectiveness of the social norms. It also finds that the perceived social norms have a stronger impact on the green consumption behaviors of consumers who value social power and social face. However, the effect becomes weaker for consumers with a strong tendency toward independence.

Originality/value
This study highlights the importance of individual difference factors in explaining the effectiveness of social norms. The current findings also offer insightful implications for designing more effective social influence approaches for constructing green consumption culture.
Understanding the demand for and value of pathogen‐free amphibians to US pet owners
Authors: Cavasos Kevin , Adhikari Ram K. , Poudyal Neelam C. , Brunner Jesse L. , Warwick Alexa R. , Gray Matthew J. 
Published: July 2023

AbstractPathogen transmission through wildlife trade has become a significant One Health issue, but businesses involved in trade can take actions to minimize pathogen spread within and beyond trade networks. Such actions could include an industry‐led clean‐trade certification program whereby retailer costs for enhanced biosecurity and disease‐free product certification are offset by increased prices to consumers. However, we currently know little about the demand for, and value of such a program to consumers. With the case of pet amphibian owners in the United States, we assessed what characteristics make people more likely to demand certified wild animals and how much more in price premium they are willing to pay for such animals. Findings suggested that the demand for pathogen‐free amphibians was driven by the perceived risk of pathogen spillover to wild populations, behavioral control in preventing transmission, and other characteristics related to pet ownership and demographics. On average, respondents were willing to pay $38.65 per animal more for certified pathogen‐free amphibians than non‐certified amphibians. Findings lend support for the viability of an industry‐led clean‐trade program aimed at enhancing animal well‐being, increasing customer satisfaction, and reducing the risk of pathogen transmission within and beyond the pet trade network.
A computational approach for the identification of key genes and biological pathways of chronic lung diseases: a systems biology approach
Authors: Rezaeeyan Hadi , Nobakht M. Gh B. Fatemeh , Arabfard Masoud 
Published: July 2023

AbstractBackgroundChronic lung diseases are characterized by impaired lung function. Given that many diseases have shared clinical symptoms and pathogenesis, identifying shared pathogenesis can help the design of preventive and therapeutic strategies. This study aimed to evaluate the proteins and pathways of chronic obstructive pulmonary disease (COPD), asthma, idiopathic pulmonary fibrosis (IPF), and mustard lung disease (MLD).Methods and resultsAfter collecting the data and determining the gene list of each disease, gene expression changes were examined in comparison to healthy individuals. Protein–protein interaction (PPI) and pathway enrichment analysis were used to evaluate genes and shared pathways of the four diseases. There were 22 shared genes, including ACTB, AHSG, ALB, APO, A1, APO C3, FTH1, GAPDH, GC, GSTP1, HP, HSPB1, IGKC, KRT10, KRT9, LCN1, PSMA2, RBP4, 100A8, S100A9, TF, and UBE2N. The major biological pathways in which these genes are involved are inflammatory pathways. Some of these genes activate different pathways in each disease, leading to the induction or inhibition of inflammation.ConclusionIdentification of the genes and shared pathways of diseases can contribute to identifying pathogenesis pathways and designing preventive and therapeutic strategies.
Effect, sensitivity, specificity and accuracy of ultrasonic assessment of axillary lymph node-negative breast cancer
Authors: Hong Chun-Tian , Yan Yong-Hao , Su Li-Yang , Chen De-Bo 
Published: July 2023

Objective: To investigate the diagnostic value of ultrasound for patients with axillary lymph node-negative breast cancer (ALNNBC).
Methods: A retrospective analysis was performed on the clinical data of 204 breast cancer patients who were admitted by Quanzhou First Hospital Affiliated to Fujian Medical University between October 2020 and May 2022. According to the results of axillary lymph node (ALN) examination, the patients were assigned to a positive group(n=102) and a negative group(n=102). All patients underwent diagnosis with color Doppler ultrasound, with pathological diagnosis as the “gold standard” to determine the sensitivity and specificity of ultrasonic diagnosis. A receiver operating characteristic(ROC) curve was established to analyze the efficiency of ultrasonic diagnosis and compare the ultrasonographic features and flow grades between the two groups.
Results: Differences were statistically significant between the two groups in ultrasonographic features of lesions(negative vs positive, all p<0.05), including morphological irregularity(59.8% vs 85.3%), spiky margins(19.6% vs 63.7%), posterior echo attenuation(19.6% vs 44.1%) and microcalcification(40.2% vs 55.89%). The negative group had a lower proportion of patients with grade 2-3 ultrasound blood flow when compared with the positive group(32.4% vs 56.86%), and the difference was statistically significant(p<0.05). Ultrasonic diagnosis of ALNNBC had a sensitivity of 88.24%(90/102), a specificity of 92.16%(94/102), a coincidence rate of 90.20% (184/204), a 95% CI of 0.845-0.928, and an AUC of 0.879.
Conclusions: Ultrasonic diagnosis of ALNNBC is relatively efficient as ultrasonographic features and ultrasound blood flow signals can provide a scientific basis for the diagnosis of ALNNBC.
doi: https://doi.org/10.12669/pjms.39.5.7260
How to cite this: Hong C, Yan Y, Su L, Chen D. Effect, sensitivity, specificity and accuracy of ultrasonic assessment of axillary lymph node-negative breast cancer. Pak J Med Sci. 2023;39(5):---------. doi: https://doi.org/10.12669/pjms.39.5.7260
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Communication culture of regional PDAM Sleman during the Covid-19 pandemic
Authors: Meylasari Meylasari Ratna Pradipta , Sugiantoro Hari Akbar Sugiantoro 
Published: July 2023

The presence of Corona Virus Desease (Covid-19) as a new variant virus brings many changes in the system and policies of a country. Various prevention efforts are carried out by the government. The Covid-19 pandemic had a significant influence on an organization's communication culture in a company. With theCovid-19 pandemic making the communication culture of organizations in a company change drastically, Anggota organization must learn the communication culture with new adaptations. This study uses descriptive qualitative research methods, Metode is related between researchers and informants directly. The purpose of this study is to find out how the communication of PDAM Sleman organization in the pandemic period is dissected using 4 organizational communication functions. And the result of this study is that PDAM Sleman has been effective in using 4 organizational communication functions even in pandemic times like now.