bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence and the Influence of Trapeziometacarpal Osteoarthritis on Patients with Carpal Tunnel Syndrome
Authors: SUGIURA Kaori , OMURA Takao , MIYAGI Michihito , SHIBATA Yosuke , MATSUYAMA Yukihiro 
Published: February 2023

Background: The coexistence of carpal tunnel syndrome (CTS) and trapeziometacarpal (TMC) osteoarthritis have been previously described. The influence of TMC osteoarthritis in the outcomes of CTS surgery is yet to be elucidated. The purpose of this study is to examine the prevalence of TMC osteoarthritis in patients who underwent open carpal tunnel release (OCTR) and to analyse the influence of osteoarthritis on the postoperative outcomes of CTS. Methods: We retrospectively reviewed 134 procedures on 113 patients who underwent OCTR between 2002 and 2017. The presence of TMC osteoarthritis was based upon preoperative plain radiograph. For the evaluation of CTS, pre- and postoperative muscle power of abductor pollicis brevis (APB) muscle by manual muscle testing (MMT) and distal motor latency (DML) detected on the APB muscle was examined. Results: The mean follow-up period was 11.4 months. The prevalence of radiographic TMC osteoarthritis was 40% in patients who underwent OCTR. In electrophysiological study, the mean pre- and postoperative DML showed no statistical difference regardless of the coexistence of TMC osteoarthritis. However, there was a significantly higher incidence of poorer muscle strength of the APB in patients with TMC osteoarthritis. No patients complained of TMC joint pain prior to OCTR, but four cases developed TMC joint pain during the postoperative follow-up period, all of whom had full recovery of APB muscle strength. Conclusions: The presence of asymptomatic TMC osteoarthritis may affect the postoperative outcomes of OCTR, so preoperative evaluation of TMC osteoarthritis should be considered in patients undergoing OCTR. In addition, the symptoms of TMC osteoarthritis may worsen in some patients after CTS surgery and should be taken into consideration during the postoperative follow-up. Level of Evidence: Level IV (Therapeutic)
Closed Traumatic Zone 2 Flexor Tendon Injury of the Long Finger – A Case Report
Authors: KRISHNA Sathya Vamsi , UMESH Shreyas , HS Chandrashekar 
Published: February 2023

Closed rupture of the flexor digitorum profundus (FDP) tendon causes loss of flexion at the distal interphalangeal joint. Following trauma, these are known to present as avulsion fractures (Jersey finger) commonly in ring fingers. Traumatic tendon ruptures at the other flexor zones are seldom noted and are often missed. In this report, we present a rare case of closed traumatic tendon rupture of the long finger FDP at zone 2. Though it was missed initially, was confirmed with Magnetic Resonance Imaging and underwent successful reconstruction using an ipsilateral palmaris longus graft. Level of Evidence: Level V (Therapeutic)
AKT Blocks SIK1-Mediated Repression of STAT3 to Promote Breast Tumorigenesis
Authors: Sun Zicheng , Jiang Qiwei , Gao Bing , Zhang Xiaomei , Bu Lang , Wang Lei , Lin Ying , Xie Wei , Li Jie , Guo Jianping 
Published: February 2023

AbstractThe PI3K–AKT signaling pathway is frequently dysregulated in cancer, and it is hyperactivated in approximately 50% of breast cancers. Although inhibitors directly targeting the PI3K–AKT axis have been developed, clinical efficacy has been limited to only a subset of patients. Identification of mechanisms underlying AKT-driven tumorigenesis could lead to alternative approaches to block pathway signaling and suppress breast tumor growth. Mass spectrometry–based analyses demonstrated that salt-inducible kinase 1 (SIK1) binds AKT and undergoes AKT-mediated phosphorylation, which compromises SIK1 tumor-suppressive functions. As a result, AKT relieved the binding and repression of STAT3 by SIK1 in a phosphorylation-dependent manner, resulting in breast cell tumorigenesis. Following AKT-mediated phosphorylation, SIK1 interacted with 14-3-3 and was translocated to the cytoplasm where the isomerase Pin1 facilitated SIK1 interaction with the E3 ligase ITCH to promote SIK1 ubiquitination and subsequent degradation. These findings indicate that SIK1 is a substrate of AKT that links AKT oncogenic function to STAT3 activation, highlighting targeting of the JAK2–STAT3 axis as a strategy to treat AKT-driven breast cancer.Significance:AKT binds and phosphorylates SIK1 to overcome SIK1-mediated repression of STAT3, indicating that STAT3 is a potential therapeutic target in breast cancer with hyperactive AKT signaling.
Recurrences of Atrial Fibrillation Despite Durable Pulmonary Vein Isolation: The PARTY-PVI Study
Authors: Benali Karim , Barré Valentin , Hermida Alexis , Galand Vincent , Milhem Antoine , Philibert Séverine , Boveda Serge , Bars Clément , Anselme Frédéric , Maille Baptiste , André Clémentine , Behaghel Albin , Moubarak Ghassan , Clémenty Nicolas , Da Costa Antoine , Arnaud Marine , Venier Sandrine , Sebag Frédéric , Jésel-Morel Laurence , Sagnard Audrey , Champ-Rigot Laure , Dang Duc , Guy-Moyat Benoit , Abbey Selim , Garcia Rodrigue , Césari Olivier , Badenco Nicolas , Lepillier Antoine , Ninni Sandro , Boulé Stéphane , Maury Philippe , Algalarrondo Vincent , Bakouboula Babé , Mansourati Jacques , Lesaffre François , Lagrange Philippe , Bouzeman Abdeslam , Muresan Lucian , Bacquelin Raoul , Bortone Agustin , Bun Sok-Sithikun , Pavin Dominique , Macle Laurent , Martins Raphaël P. 
Published: February 2023

Background:
Recurrences of atrial fibrillation (AF) after pulmonary vein isolation (PVI) are mainly due to pulmonary vein reconnection. However, a growing number of patients have AF recurrences despite durable PVI. The optimal ablative strategy for these patients is unknown. We analyzed the impact of current ablation strategies in a large multicenter study.

Methods:
Patients undergoing a redo ablation for AF and presenting durable PVI were included. The freedom from atrial arrhythmia after pulmonary vein-based, linear-based, electrogram-based, and trigger-based ablation strategies were compared.

Results:

Between 2010 and 2020, 367 patients (67% men, 63±10 years, 44% paroxysmal) underwent a redo ablation for AF recurrences despite durable PVI at 39 centers. After durable PVI was confirmed, linear-based ablation was performed in 219 (60%) patients, electrogram-based ablation in 168 (45%) patients, trigger-based ablation in 101 (27%) patients, and pulmonary vein-based ablation in 56 (15%) patients. Seven patients (2%) did not undergo any additional ablation during the redo procedure. After 22±19 months of follow-up, 122 (33%) and 159 (43%) patients had a recurrence of atrial arrhythmia at 12 and 24 months, respectively. No significant difference in arrhythmia-free survival was observed between the different ablation strategies. Left atrial dilatation was the only independent factor associated with arrhythmia-free survival (HR, 1.59 [95% CI, 1.13–2.23];
P
=0.006).

Conclusions:
In patients with recurrent AF despite durable PVI, no ablation strategy used alone or in combination during the redo procedure appears to be superior in improving arrhythmia-free survival. Left atrial size is a significant predictor of ablation outcome in this population.
Higher Maternal Cortisol Associated With Lower Blood Pressure in Offspring From 3 Months to 5 Years of Age in the Odense Child Cohort
Authors: Al-Jorani Hajir , Jensen Richard Christian , Jonasson Mikaela T.E. , Birukov Anna , Schmedes Anne Vibeke , Christesen Henrik Thybo , Dreyer Anja F. , Jensen Tina K. , Glintborg Dorte , Jensen Boye L. , Andersen Marianne S. 
Published: February 2023

Background:
Synthetic glucocorticoid exposure in late pregnancy may be associated with higher blood pressure in offspring. We hypothesized that endogenous cortisol in pregnancy relates to offspring blood pressure (OBP).

Objective:
To investigate associations between maternal cortisol status in third trimester pregnancy and OBP.

Methods:
We included 1317 mother-child pairs from Odense Child Cohort, an observational prospective cohort. Serum (s-) cortisol and 24-hour urine (u-) cortisol and cortisone were assessed in gestational week 28. Offspring systolic blood pressure and diastolic blood pressure were measured at age 3, 18 months, and 3 and 5 years. Associations between maternal cortisol and OBP were examined by mixed effects linear models.

Results:
All significant associations between maternal cortisol and OBP were negative. In boys in pooled analyses, 1 nmol/L increase in maternal s-cortisol was associated with average decrease in systolic blood pressure (β=−0.003 mmHg [95% CI, −0.005 to −0.0003]) and diastolic blood pressure (β=−0.002 mmHg [95% CI, −0.004 to −0.0004]) after adjusting for confounders. At 3 months of age, higher maternal s-cortisol was significantly associated with lower systolic blood pressure (β=−0.01 mmHg [95% CI, −0.01 to −0.004]) and diastolic blood pressure (β=−0.010 mmHg [95% CI, −0.012 to −0.011]) in boys after adjusting for confounders, which remained significant after adjusting for potential intermediate factors.

Conclusions:
We found temporal sex dimorphic negative associations between maternal s-cortisol levels and OBP, with significant findings in boys. We conclude that physiological maternal cortisol is not a risk factor for higher blood pressure in offspring up to 5 years of age.
Role of PARP and TRPM2 in VEGF Inhibitor‐Induced Vascular Dysfunction
Authors: Neves Karla B. , Alves‐Lopes Rheure , Montezano Augusto C. , Touyz Rhian M. 
Published: February 2023

Background
Hypertension and vascular toxicity are major unwanted side effects of antiangiogenic drugs, such as vascular endothelial growth factor inhibitors (VEGFis), which are effective anticancer drugs but have unwanted side effects, including vascular toxicity and hypertension. Poly (ADP‐ribose) polymerase (PARP) inhibitors, used to treat ovarian and other cancers, have also been associated with elevated blood pressure. However, when patients with cancer receive both olaparib, a PARP inhibitor, and VEGFi, the risk of blood pressure elevation is reduced. Underlying molecular mechanisms are unclear, but PARP‐regulated transient receptor potential cation channel, subfamily M, member 2 (TRPM2), a redox‐sensitive calcium channel, may be important. We investigated whether PARP/TRPM2 plays a role in VEGFi‐induced vascular dysfunction and whether PARP inhibition ameliorates the vasculopathy associated with VEGF inhibition.

Methods and Results

Human vascular smooth muscle cells (VSMCs), human aortic endothelial cells, and wild‐type mouse mesenteric arteries were studied. Cells/arteries were exposed to axitinib (VEGFi) alone and in combination with olaparib. Reactive oxygen species production, Ca
2+
influx, protein/gene analysis, PARP activity, and TRPM2 signaling were assessed in VSMCs, and nitric oxide levels were determined in endothelial cells. Vascular function was assessed by myography. Axitinib increased PARP activity in VSMCs in a reactive oxygen species‐dependent manner. Endothelial dysfunction and hypercontractile responses were ameliorated by olaparib and a TRPM2 blocker (8‐Br‐cADPR). VSMC reactive oxygen species production, Ca
2+
influx, and phosphorylation of myosin light chain 20 and endothelial nitric oxide synthase (Thr
495
) were augmented by axitinib and attenuated by olaparib and TRPM2 inhibition. Proinflammatory markers were upregulated in axitinib‐stimulated VSMCs, which was reduced by reactive oxygen species scavengers and PARP‐TRPM2 inhibition. Human aortic endothelial cells exposed to combined olaparib and axitinib showed nitric oxide levels similar to VEGF‐stimulated cells.

Conclusions
Axitinib‐mediated vascular dysfunction involves PARP and TRPM2, which, when inhibited, ameliorate the injurious effects of VEGFi. Our findings define a potential mechanism whereby PARP inhibitor may attenuate vascular toxicity in VEGFi‐treated patients with cancer.
The Political Dimension of Modernity and the Unsurpassable Exteriority of ‘Nature’
Authors: Domingues José Maurício 
Published: February 2023

Abstract
The environment and climate change have achieved global, imaginary and institutional, centrality. Yet, despite efforts by social movements and intellectuals to change the status of ‘nature’ in social life, its unsurpassable exteriority in relation to ‘society’ remains a defining feature of modernity. While the imaginary is to a large extent fluid, these are core elements that hardly change, and by the same token are hard to change, one of the reasons being that they are crystalized in institutions, which contributes to their recursiveness and reiteration. This article explores the reasons for this, reconstructing the modern perspective, the role of subjectivity in it and some alternative views while focusing on the political dimension of modernity. It then goes on to tackle contemporary issues. If we aim to bring about a different world, and this does not exclude recourse to different civilizational alternatives, I argue that it is mostly from within the modern imaginary and institutional framework that we must face up to present challenges. I also suggest that the concepts of collective subjectivity and materiality may contribute to a renewed understanding of these questions within a critical theory perspective.
Gender Between Imaginary Institution and Cultural Incorporation
Authors: Pechriggl Alice 
Published: February 2023

Abstract
In this article, the author tries to show how the concept of anaclisis forged by Freud and further elaborated by Castoriadis can help to conceive ‘gender’ as a phenomenon between body and imaginary, between bios and nomos or, in Castoriadis’s words, between a ‘first natural stratum’ and ‘imaginary institution’. By analyzing the concept of imagination as related to the body in Castoriadis’s latest text and in an unpublished seminar on psychoanalysis, the article furthermore opens the gaze to the chiasmatic interrelation between body and psyche on the one hand, and between imaginary representation (mise en scène) as well as institution and cultural incorporation on the other. Revisiting the concept of anaclisis as well as its limits should permit a better understanding of the gender-imaginary and its relation to the body.
A Conversation on Social Imaginaries: Culture, Power, Action, World
Authors: Adams Suzi , Arnason Johann P. 
Published: February 2023

Abstract
The conversation begins with reflections on social imaginaries as a crossroads concept, capable of integrating insights from multiple sources; this point is developed through references to the works of Marx, Durkheim and Weber, and followed by comments on Charles Taylor’s hermeneutical realism, as well as on the task of rethinking psychoanalysis. Marcel Gauchet’s approach is noted as the most promising perspective on the latter field. Further discussion deals with the concept of imaginary significations as a key to the theory of culture, and then moves on to two foreshadowed but notably underdeveloped themes in Castoriadis’s work: the symbolic and the problems of theorizing action. Both of them are linked to the phenomenological notion of the world. The final section raises the question of power and emphasizes the affinity of social imaginaries with a relational understanding of power.
Attributing the Urban–Rural Contrast of Heat Stress Simulated by a Global Model
Authors: Qin Yue , Liao Weilin , Li Dan 
Published: February 2023

Abstract
The two-resistance mechanism (TRM) attribution method, which was designed to analyze the urban–rural contrast of temperature, is improved to study the urban–rural contrast of heat stress. The improved method can be applied to diagnosing any heat stress index that is a function of temperature and humidity. As an example, in this study we use it to analyze the summertime urban–rural contrast of simplified wet bulb globe temperature (SWBGT) simulated by the Geophysical Fluid Dynamics Laboratory land model coupled with an urban canopy model. We find that the urban–rural contrast of SWBGT is primarily caused by the lack of evapotranspiration in urban areas during the daytime and the release of heat storage during the nighttime, with the urban–rural differences in aerodynamic features playing either positive or negative roles depending on the background climate. Compared to the magnitude of the urban–rural contrast of temperature, the magnitude of the urban–rural contrast of SWBGT is damped due to the moisture deficits in urban areas. We further find that the urban–rural contrast of 2-m air temperature/SWBGT is fundamentally different from that of canopy air temperature/SWBGT. Turbulent mixing in the surface layer leads to much smaller urban–rural contrasts of 2-m air temperature/SWBGT than their canopy air counterparts.

Significance Statement
Heat leads to serious public health concerns, but urban and rural areas have different levels of heat stress. Our study explains the magnitude and pattern of the simulated urban–rural contrast in heat stress at the global scale and improves an attribution method to quantify which biophysical processes are mostly responsible for the simulated urban–rural contrast in heat stress. We highlight two well-known causes of higher heat stress in cities: the lack of evapotranspiration and the stronger release of heat storage. Meanwhile, we draw attention to the vegetation types in rural areas, which determine the urban–rural difference in surface roughness and significantly affect the urban–rural difference in heat stress. Last, we find the urban–rural contrasts of 2-m air temperature/SWBGT are largely reduced relative to their canopy air counterparts due to the turbulent mixing effect.
The Impact of Alcohol Level on Elderly Trauma Patients Presenting to the Emergency Department
Authors: Wasfie Tarik , White Hutton , Casey Taylor , Hella Jennifer , Barber Kimberly , Shapiro Brian 
Published: February 2023

Alcohol is a chemical substance that alters cognitive ability and judgment. We looked at our elderly patients that arrived at the Emergency Department (ED) following trauma and evaluated the factors that may influence outcome. Retrospective analysis of patients seen in ED with positive alcohol was performed. Statistical analysis was performed to identify the confounding factors for outcomes. Records collected on 449 patients with a mean age of 42 ± 16.9 years. There were 314 males (70%) and 135 females (30%). Average GCS was 14, and average ISS was 7.0. Mean alcohol level was 176 g/dL ± 91.6. There were 48 patients aged 65 years and older with significantly higher hospital stay (4.1 and 2.8 days, P = .019) and ICU stay (2.4 and 1.2 days, P = .003) compared to the 64 and younger group. Elderly trauma patients had a higher mortality and length of stay due to a higher number of comorbidities.
Health education and promotion of #PhysicalActivity on Twitter before and during COVID-19
Authors: Farley Zachary S , McDonough Kalyn , Richards Elizabeth A , Smock Carissa R 
Published: February 2023

Objective: Twitter, a microblogging service, allows users to post short messages (tweets) and link posts through hashtags, creating online communities to enable dissemination of health education. The objective of this descriptive study was to examine Twitter’s #PhysicalActivity health education and promotion efforts, including differences in response before (March 2019–February 2020) and during (March 2020–February 2021) the COVID-19 pandemic. Design, setting and methods: A codebook was developed to conduct a quantitative content analysis of #PhysicalActivity tweets before and during the COVID-19 pandemic. Twitter’s Advanced Search parameters included minimum 1 reply, 25 likes and 5 retweets. Tweets were double-coded for user characteristics, community response, tweet elements (video, photo, link, questions, events, original text, survey/response, journal article, infographic) and intended audience. T-tests examined differences in researcher-generated NET response (replies + retweets + likes) between COVID-19 and comparison years. Results: Data were collected from 400 tweets. Eighty percent of tweets were from personal accounts, with over half indicating the possession of a health professional degree. Twenty-nine percent of tweets gave behavioural recommendations of which 56.8% provided a rationale. Nearly all used at least two components, text and photos most common. The general public was the most intended audience with health professionals second. While the NET response was greater during COVID-19 ( M = 139.6, SD = 156.8) than prior to it ( M = 116.8, SD = 105.1), the difference was not statistically significant ( p = .091). Conclusion: Twitter platform provided an opportunity to disseminate health education, specifically for the promotion of physical activity, while adhering to public health recommendations to #StaySafeStayHome. Our findings provide insights into engaging this online community to inform future physical education and promotion dissemination.
Bolsonaro’s Subservience to Trump, 2019 and 2020: A Demanding Agenda and Limited Reciprocity
Authors: Thomaz Laís Forti , Vigevani Tullo 
Published: February 2023

In the relationship between Brazil and the United States during the Bolsonaro and Trump administrations (2019 and 2020), Brazil advanced a demanding agenda that met with limited reciprocity. John Kingdon’s concept of the policy window is useful for explaining that the two presidents, having similar worldviews, saw the possibility of moving forward with this agenda, but Brazil’s subservient position ended up compromising its bargaining position. In the case of the commercial aspects of the Alcântara technological safeguards agreement, Brazil’s unilateral concessions failed to generate concrete results before this window was closed and even set the country on the path toward becoming an international pariah. O governo brasileiro promoveu uma agenda ambiciosa que facilitou pouca reciprocidade na relação entre o Brasil e os Estados Unidos durante os governos Bolsonaro e Trump (2019 e 2020). O conceito de John Kingdon do policy window é útil para explicar o fato que ambos os presidentes, além de partilhar visões semelhantes do mundo, viram a possibilidade de avançarem esta agenda. Contudo, a posição submissa do Brasil acabou em comprometer sua posição negocial. No caso dos aspectos comerciais do acordo das salvagardas tecnológicas da Alcântara, o Brasil deixou passar essa oportunidade porque as concessões unilaterais do governo brasileiro falharam em produzir resultados concretos e, ademais, colocou o país no caminho de se tornar um paria internacional.
The State, Accumulation, and Oaxaca’s Earthquake Survivors: Three Mechanisms of Inequality
Authors: Morosin Alessandro 
Published: February 2023

Ethnographic field interviews collected in three municipalities of Oaxaca explain how the Mexican state’s response to the Chiapas earthquake facilitated capital accumulation while intensifying indigenous-campesino grievances against megaprojects and resource extraction. State policies in Oaxaca’s Isthmus of Tehuantepec during the fall of 2017 reinforced social inequality by way of three key mechanisms: neglect, dispossession, and pacification. Making sense of the way state institutions exercised power during this disaster benefits from combining a critical perspective on global capitalism with long-standing frameworks of cultural genocide and internal colonialism. Las entrevistas de campo etnográficas recogidas en tres municipios de Oaxaca nos muestran cómo la respuesta del Estado mexicano al terremoto de Chiapas facilitó la acumulación de capital al mismo tiempo que intensificó las quejas de campesinos indígenas contra los megaproyectos y la extracción de recursos. Las políticas estatales en el istmo de Tehuantepec en Oaxaca durante el otoño de 2017 reforzaron la desigualdad social a través de tres mecanismos clave: abandono, despojo y pacificación. Para poder dar sentido a la forma en que las instituciones estatales ejercieron el poder durante este desastre es importante combinar una perspectiva crítica sobre el capitalismo global y marcos teóricos de larga data en torno al genocidio cultural y el colonialismo interno.