bluuebunny/crossref_metadata_2025_split huggingface dataset:
Are parents of high caries risk Dutch children motivated to brush their children’s teeth? An assessment using the health action process approach questionnaire
Authors: van Nes K. A. , Bonifácio C. C. , van Hunnik M. M. , van Loveren C. , Aartman I. H. A. 
Published: July 2023

Abstract
Purpose
To assess the social cognitive constructs of the Health Action Process Approach (HAPA) of parents of high caries risk children to be treated under intravenous sedation (IVS) or with behavioural guidance techniques (BGT), and to assess the changes in these constructs for each treatment group after treatment.

Design
In this cohort study, 160 children aged 3–10 years were allocated by their paediatric dentist to either IVS (77.4%) or BGT. Their parents filled out a HAPA questionnaire, before (T1, n = 160), immediately (T2, n = 108) and three months (T3, n = 71) after their children's dental rehabilitation.

Results
Before treatment, all parents had high scores on all social cognitive constructs. There were no differences in mean HAPA scores between the treatment groups (p > 0.05). After treatment, mean scores changed in both groups. In the BGT group, action self-efficacy changed from 3.64 (T1) to 3.36(T2) (p = 0.027) and to 3.13 (T3) (p = 0.021) and coping self-efficacy changed from 3.63 (T1) to 3.23 (T2) (p = 0.015). In the IVS group, action planning changed from 3.25 (T1) to 3.05(T3) (p = 0.036) and action control changed from 2.58 (T1) to 2.82 (T2) (p = 0.012) and to 2.87 (T3) (p = 0.006).

Conclusions
High scores on social cognitive constructs of parents of children referred to a paediatric dentist showed that they seem to be motivated to brush their children’s teeth, irrespective of the treatment group. Small changes were observed in the HAPA constructs, however, these are not considered clinically relevant.
Urban flood risk assessment using AHP and geospatial techniques in swat Pakistan
Authors: Waseem Muhammad , Ahmad Sareer , Ahmad Izhar , Wahab Hira , Leta Megersa Kebede 
Published: July 2023

AbstractThe rapid urbanization and changing climate patterns in Swat, Pakistan have increased the vulnerability of urban areas to flood events. Accurate assessment of flood risk is crucial for effective urban planning and disaster management. In current research study flood hazard index was developed using analytic hierarchy process (AHP) technique in combination with the geographical information system (GIS) environment in Swat, Pakistan. The study integrates various data sources, including topographic maps, land use/land cover information, rainfall data, and infrastructure data, to develop a comprehensive flood risk assessment model. The weights obtained from the AHP analysis are combined with geospatial data using a geographic information system (GIS) to generate flood risk maps. The flood hazard levels were categorized into five distinct classes: very low, low, moderate, high, and very high. Using the GIS-AHP approach, higher weights were assigned to rainfall, distance to river, elevation, and slope in comparison to NDVI, TWI, LULC, curvature, and soil type. The flood hazard map was then reclassified for each parameter. By overlaying these maps, it was determined that 5.6% of the total area is classified as very high flood risk, 52% as high risk, 39.3% as moderate risk, and 3.1% as low risk. The developed comprehensive flood risk assessment model in current study can identify high-risk areas, prioritize mitigation measures, and aid in effective urban planning and disaster management.
Sensory and affective aspects of the perception of respiratory resistance
Authors: Drozdovszky Orsolya , Petzke Tara , Köteles Ferenc 
Published: July 2023

AbstractPerception of airway resistance has a sensory and an affective aspect, i.e., perceived resistance and unpleasantness, respectively. The current study aimed to shed more light on the relationship of these aspects, as well as their malleability to trait-like aspects of body awareness. In a laboratory study, 71 young participants completed two respiratory resistive load discrimination tasks relying on sensory and affective evaluation, respectively, and filled out questionnaires assessing somatosensory amplification, anxiety sensitivity, somatic symptoms distress, and breath awareness. Frequentist and Bayesian statistical analysis revealed no differences in discrimination accuracy with respect to the sensory and affective aspect of perceived resistance. Psychological traits were not associated with accuracy scores. In conclusion, affective evaluation of respiratory load is as accurate as sensory evaluation. Neither sensory not affective accuracy is influenced by various aspects of body awareness.
Hydrodynamics and Sediment Transport of Downslope Turbidity Current Through Rigid Vegetation
Authors: Han Dongrui , He Zhiguo , Lin Ying‐Tien , Wang Yuhang , Guo Yakun , Yuan Yeping 
Published: July 2023

AbstractSystematical downslope‐turbidity‐current experiments were performed to clarify the relationship between sediment‐transport modes and current propagation patterns caused by rigid vegetation, as well as adjustments in turbulence characteristics of current. The equations for predicting the front velocities of downslope turbidity currents with emergent vegetation were proposed and validated via experimental data. Experimental results reveal that sediment deposition causes the lower turbulent kinetic energy (TKE) peaks of turbidity currents to decrease or even disappear without affecting their upper TKE peaks, while the rigid vegetation has the opposite effect. Vegetation stems destroy the longitudinal low‐high speed streaks associated with the quasi‐streamwise eddies in the near‐bed region and increase the proportions of the outward and inward interactions. In addition, sediment deposition severely suppresses the turbulent bursting events within turbidity currents but does not influence the relative proportions of the four bursting types. Rigid vegetation and sediment deposition both degrade the absolute values of the third‐order moments of velocity fluctuations without changing their signs to reduce the generation frequency of sweep events. Emergent rigid vegetation accelerates the formation of the reflected bore to provide energy for the deposited sediment to move downstream continuously. On the other hand, the dense submerged vegetation makes turbidity currents easily form the two‐head propagating mode, which allows part of the sediments carried by the upper current head to be transported downstream rather than deposited within or upstream of the vegetation region. Furthermore, the sloping boundary provides favorable conditions to initiate these specific modes for sediment transport adjusted by rigid vegetation.
Future increased risk from extratropical windstorms in northern Europe
Authors: Little Alexander S. , Priestley Matthew D. K. , Catto Jennifer L. 
Published: July 2023

AbstractEuropean windstorms cause socioeconomic losses due to wind damage. Projections of future losses from such storms are subject to uncertainties from the frequency and tracks of the storms, their intensities and definitions thereof, and socio-economic scenarios. We use two storm severity indices applied to objectively identified extratropical cyclone footprints from a multi-model ensemble of state-of-the-art climate models under different future socio-economic scenarios. Here we show storm frequency increases across northern and central Europe, where the meteorological storm severity index more than doubles. The population-weighted storm severity index more than triples, due to projected population increases. Adapting to the increasing wind speeds using future damage thresholds, the population weighted storm severity index increases are only partially offset, despite a reduction in the meteorological storm severity through adaptation. Through following lower emissions scenarios, the future increase in risk is reduced, with the population-weighted storm severity index increase more than halved.
Facilitating two-electron oxygen reduction with pyrrolic nitrogen sites for electrochemical hydrogen peroxide production
Authors: Peng Wei , Liu Jiaxin , Liu Xiaoqing , Wang Liqun , Yin Lichang , Tan Haotian , Hou Feng , Liang Ji 
Published: July 2023

AbstractElectrocatalytic hydrogen peroxide (H2O2) production via the two-electron oxygen reduction reaction is a promising alternative to the energy-intensive and high-pollution anthraquinone oxidation process. However, developing advanced electrocatalysts with high H2O2 yield, selectivity, and durability is still challenging, because of the limited quantity and easy passivation of active sites on typical metal-containing catalysts, especially for the state-of-the-art single-atom ones. To address this, we report a graphene/mesoporous carbon composite for high-rate and high-efficiency 2e− oxygen reduction catalysis. The coordination of pyrrolic-N sites -modulates the adsorption configuration of the *OOH species to provide a kinetically favorable pathway for H2O2 production. Consequently, the H2O2 yield approaches 30 mol g−1 h−1 with a Faradaic efficiency of 80% and excellent durability, yielding a high H2O2 concentration of 7.2 g L−1. This strategy of manipulating the adsorption configuration of reactants with multiple non-metal active sites provides a strategy to design efficient and durable metal-free electrocatalyst for 2e− oxygen reduction.
LILRB2/PirB mediates macrophage recruitment in fibrogenesis of nonalcoholic steatohepatitis
Authors: Li Dan-Pei , Huang Li , Kan Ran-Ran , Meng Xiao-Yu , Wang Shu-Yun , Zou Hua-Jie , Guo Ya-Ming , Luo Pei-Qiong , Pan Li-Meng , Xiang Yu-Xi , Mao Bei-Bei , Xie Yu-Yu , Wang Zhi-Han , Yang Min , He Rui , Yang Yan , Liu Zhe-Long , Xie Jun-Hui , Ma De-Lin , Zhang Ben-Ping , Shao Shi-Ying , Chen Xi , Xu Si-Miao , He Wen-Tao , Li Wen-Jun , Chen Yong , Yu Xue-Feng 
Published: July 2023

AbstractInhibition of immunocyte infiltration and activation has been suggested to effectively ameliorate nonalcoholic steatohepatitis (NASH). Paired immunoglobulin-like receptor B (PirB) and its human ortholog receptor, leukocyte immunoglobulin-like receptor B (LILRB2), are immune-inhibitory receptors. However, their role in NASH pathogenesis is still unclear. Here, we demonstrate that PirB/LILRB2 regulates the migration of macrophages during NASH by binding with its ligand angiopoietin-like protein 8 (ANGPTL8). Hepatocyte-specific ANGPTL8 knockout reduces MDM infiltration and resolves lipid accumulation and fibrosis progression in the livers of NASH mice. In addition, PirB−/− bone marrow (BM) chimeras abrogate ANGPTL8-induced MDM migration to the liver. And yet, PirB ectodomain protein could ameliorate NASH by sequestering ANGPTL8. Furthermore, LILRB2-ANGPTL8 binding-promoted MDM migration and inflammatory activation are also observed in human peripheral blood monocytes. Taken together, our findings reveal the role of PirB/LILRB2 in NASH pathogenesis and identify PirB/LILRB2-ANGPTL8 signaling as a potential target for the management or treatment of NASH.
Molecular basis for selective uptake and elimination of organic anions in the kidney by OAT1
Authors: Parker Joanne L. , Kato Takafumi , Kuteyi Gabriel , Sitsel Oleg , Newstead Simon 
Published: July 2023

AbstractIn mammals, the kidney plays an essential role in maintaining blood homeostasis through the selective uptake, retention or elimination of toxins, drugs and metabolites. Organic anion transporters (OATs) are responsible for the recognition of metabolites and toxins in the nephron and their eventual urinary excretion. Inhibition of OATs is used therapeutically to improve drug efficacy and reduce nephrotoxicity. The founding member of the renal organic anion transporter family, OAT1 (also known as SLC22A6), uses the export of α-ketoglutarate (α-KG), a key intermediate in the Krebs cycle, to drive selective transport and is allosterically regulated by intracellular chloride. However, the mechanisms linking metabolite cycling, drug transport and intracellular chloride remain obscure. Here, we present cryogenic-electron microscopy structures of OAT1 bound to α-KG, the antiviral tenofovir and clinical inhibitor probenecid, used in the treatment of Gout. Complementary in vivo cellular assays explain the molecular basis for α-KG driven drug elimination and the allosteric regulation of organic anion transport in the kidney by chloride.
Adjunctive intravenous then oral vitamin C for moderate and severe community-acquired pneumonia in hospitalized adults: feasibility of randomized controlled trial
Authors: Chambers Stephen T. , Storer Malina , Scott-Thomas Amy , Slow Sandy , Williman Jonathan , Epton Michael , Murdoch David R. , Metcalf Sarah , Carr Anitra , Isenman Heather , Maze Michael 
Published: July 2023

AbstractPatients hospitalised with community acquired pneumonia (CAP) have low peripheral blood vitamin C concentrations and limited antioxidant capacity. The feasibility of a trial of vitamin C supplementation to improve patient outcomes was assessed. Participants with moderate and severe CAP (CURB-65 ≥ 2) on intravenous antimicrobial treatment were randomised to either intravenous vitamin C (2.5 g 8 hourly) or placebo before switching to oral intervention (1 g tds) for 7 days when they were prescribed oral antimicrobial therapy. Of 344 patients screened 75 (22%) were randomised and analysed. The median age was 76 years, and 43 (57%) were male. In each group, one serious adverse event that was potentially intervention related occurred, and one subject discontinued treatment. Vitamin C concentrations were 226 µmol/L in the vitamin C group and 19 µmol/L in the placebo group (p < 0.001) after 3 intravneous doses. There were no signficant differences between the vitamin C and placebo groups for death within 28 days (0 vs. 2;p = 0.49), median length of stay (69 vs. 121 h;p = 0.07), time to clinical stability (22 vs. 49 h;p = 0.08), or readmission within 30 days (1 vs. 4;p = 0.22). The vitamin C doses given were safe, well tolerated and saturating. A randomised controlled trial to assess the efficacy of vitamin C in patients with CAP would require 932 participants (CURB-65 ≥ 2) to observe a difference in mortality and 200 participants to observe a difference with a composite endpoint such as mortality plus discharge after 7 days in hospital. These studies are feasible in a multicentre setting.
Meta-analysis and moderator analysis of the seroprevalence of hepatitis E in South-Eastern Asia
Authors: Raji Yakubu Egigogo , Toung Ooi Peck , Taib Niazlin Mohd , Sekawi Zamberi Bin 
Published: July 2023

AbstractBy 2030, the World Health Organization wants to decrease viral hepatitis incidence and mortality by 90% and 65%, respectively. One of the agents responsible for the increased burden of viral hepatitis is the hepatitis E virus (HEV). This emerging pathogen is prevalent worldwide causing both acute and chronic infection. The rising risk profile of HEV has become a source of increased global public health concern. Despite this challenge, South-Eastern Asia (SEA), where many at-risk people are found, lacks uniform HEV prevalence data. Therefore, a meta-analysis was conducted to assess the overall prevalence of hepatitis E in SEA. Using R statistical software, a random effect model was used to estimate the logit-transformed prevalence. Moderator analyses were used to investigate the potential sources of variation. Thirty-two studies comprising 29,944 with 6806 anti-HEV antibody-positive individuals were evaluated. The overall HEV seroprevalence in SEA was 21% (95% confidence interval [CI]: 17–27) with high heterogeneity. At the country level, Laos has the highest prevalence estimate of 39% (CI: 16–69). Also, the studied population, year of publication, duration of sampling, and diagnostic method are significant HEV prevalence predictors accounting for 22.61% of the observed heterogeneity. The high HEV prevalence found in this study necessitates coordinated national and regional efforts to combat this emerging disease.
Enzyme stabilization and thermotolerance function of the intrinsically disordered LEA2 proteins from date palm
Authors: Aziz Mughair Abdul , Sabeem Miloofer , Kutty M. Sangeeta , Rahman Shafeeq , Alneyadi Maitha Khalfan , Alkaabi Alia Binghushoom , Almeqbali Eiman Saeed , Brini Faical , Vijayan Ranjit , Masmoudi Khaled 
Published: July 2023

AbstractIn date palm, the LEA2 genes are of abundance with sixty-two members that are nearly all ubiquitous. However, their functions and interactions with potential target molecules are largely unexplored. In this study, five date palm LEA2 genes, PdLEA2.2, PdLEA2.3, PdLEA2.4, PdLEA2.6, and PdLEA2.7 were cloned, sequenced, and three of them, PdLEA2.2, PdLEA2.3, and PdLEA2.4 were functionally characterized for their effects on the thermostability of two distinct enzymes, lactate dehydrogenase (LDH) and β-glucosidase (bglG) in vitro. Overall, PdLEA2.3 and PdLEA2.4 were moderately hydrophilic, PdLEA2.7 was slightly hydrophobic, and PdLEA2.2 and PdLEA2.6 were neither. Sequence and structure prediction indicated the presence of a stretch of hydrophobic residues near the N-terminus that could potentially form a transmembrane helix in PdLEA2.2, PdLEA2.4, PdLEA2.6 and PdLEA2.7. In addition to the transmembrane helix, secondary and tertiary structures prediction showed the presence of a disordered region followed by a stacked β-sheet region in all the PdLEA2 proteins. Moreover, three purified recombinant PdLEA2 proteins were produced in vitro, and their presence in the LDH enzymatic reaction enhanced the activity and reduced the aggregate formation of LDH under the heat stress. In the bglG enzymatic assays, PdLEA2 proteins further displayed their capacity to preserve and stabilize the bglG enzymatic activity.
Topic modeling in density functional theory on citations of condensed matter electronic structure packages
Authors: Dumaz Marie , Romero-Bohórquez Camila , Adjeroh Donald , Romero Aldo H. 
Published: July 2023

AbstractWith an increasing number of new scientific papers being released, it becomes harder for researchers to be aware of recent articles in their field of study. Accurately classifying papers is a first step in the direction of personalized catering and easy access to research of interest. The field of Density Functional Theory (DFT) in particular is a good example of a methodology used in very different studies, and interconnected disciplines, which has a very strong community publishing many research articles. We devise a new unsupervised method for classifying publications, based on topic modeling, and use a DFT-related selection of documents as a use case. We first create topics from word analysis and clustering of the abstracts from the publications, then attribute each publication/paper to a topic based on word similarity. We then make interesting observations by analyzing connections between the topics and publishers, journals, country or year of publication. The proposed approach is general, and can be applied to analyze publication and citation trends in other areas of study, beyond the field of Density Function Theory.
Lexicon for classifying ear-canal shapes
Authors: Martinez J. C. , Hwee Goh Zhi , Yap Luis , De Chua Kenneth Wei , Kamath Savitha , Chung Conrad Kang Rui , Teo Wendy Yu Bing , Tan Charmaine Kai Ling , Dritsas Stylianos , Simpson Robert E. 
Published: July 2023

AbstractThe ear canal is usually described as an S-shaped funnel. In attempting to classify ear-canal shapes obtained from point clouds digitized from molds of 300 ears, the problem of designing criteria for distinguishing and organizing the canal shapes arose. In this work, we extracted features inspired by the S-shape characteristic (critical point, maximum, minimum, twist, writhe, translation, rotation) and, through them, introduced 14 types of ear-canal shapes. This classification allowed comparison of ears within a type and of ears between different types. It expanded our range of descriptors of canal shapes and unlocked perspectives for applications.
Descriptive norms caused increases in mask wearing during the COVID-19 pandemic
Authors: Heiman Samantha L. , Claessens Scott , Ayers Jessica D. , Guevara Beltrán Diego , Van Horn Andrew , Hirt Edward R. , Aktipis Athena , Todd Peter M. 
Published: July 2023

AbstractHuman sociality is governed by two types of social norms: injunctive norms, which prescribe what people ought to do, and descriptive norms, which reflect what people actually do. The process by which these norms emerge and their causal influences on cooperative behavior over time are not well understood. Here, we study these questions through social norms influencing mask wearing during the COVID-19 pandemic. Leveraging 2 years of data from the United States (18 time points; n = 915), we tracked mask wearing and perceived injunctive and descriptive mask wearing norms as the pandemic unfolded. Longitudinal trends suggested that norms and behavior were tightly coupled, changing quickly in response to public health recommendations. In addition, longitudinal modeling revealed that descriptive norms caused future increases in mask wearing across multiple waves of data collection. These cross-lagged causal effects of descriptive norms were large, even after controlling for non-social beliefs and demographic variables. Injunctive norms, by contrast, had less frequent and generally weaker causal effects on future mask wearing. During uncertain times, cooperative behavior is more strongly driven by what others are actually doing, rather than what others think ought to be done.
Intact predictive processing in autistic adults: evidence from statistical learning
Authors: Pesthy Orsolya , Farkas Kinga , Sapey-Triomphe Laurie-Anne , Guttengéber Anna , Komoróczy Eszter , Janacsek Karolina , Réthelyi János M. , Németh Dezső 
Published: July 2023

AbstractImpairment in predictive processes gained a lot of attention in recent years as an explanation for autistic symptoms. However, empirical evidence does not always underpin this framework. Thus, it is unclear what aspects of predictive processing are affected in autism spectrum disorder. In this study, we tested autistic adults on a task in which participants acquire probability-based regularities (that is, a statistical learning task). Twenty neurotypical and 22 autistic adults learned a probabilistic, temporally distributed regularity for about 40 min. Using frequentist and Bayesian methods, we found that autistic adults performed comparably to neurotypical adults, and the dynamics of learning did not differ between groups either. Thus, our study provides evidence for intact statistical learning in autistic adults. Furthermore, we discuss potential ways this result can extend the scope of the predictive processing framework, noting that atypical processing might not always mean a deficit in performance.