bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison and analysis of clinical and pathological characteristics of patients with porto-sinusoidal vascular disease and liver cirrhosis
Authors: Tian Aiping , Qian Zibing , Mao Yongwu , Xiong Wanyuan , Mao Xiaorong 
Published: June 2023

AbstractObjective:Compare the clinical and pathological features of patients with porto-sinusoidal vascular disease (PSVD) and liver cirrhosis (LC) to reduce the rate of misdiagnosis and underdiagnosis.Methods:A total of 45 PSVD and 48 LC inpatients were included in the study as the study group and control group respectively. Clinical, imaging and liver pathology data were collected for each patient.Results:The ratio of male to female in the two groups was 1:1.25 and 0.78:1, respectively, and the average age of PSVD patients was lower.Compared to patients with cirrhosis, PSVD patients had better overall liver function. Compared to LC patients, PSVD patients had better overall liver function. Patients with PSVD had better overall liver function, and although most patients in both groups had a Child-Pugh score of B, more than two times fewer patients in the PSVD group had a Child-Pugh score of C and/or a model for end-stage liver disease(MELD) ≥ 10 than in the LC group. The initial diagnosis rate of PSVD patients was 6.67%, and nearly half of PSVD patients were misdiagnosed as LC, while the initial diagnosis rate of liver cirrhosis was 95.83%, and the diagnostic rate was higher (P<0.001). Both groups had obvious manifestations of portal hypertension on imaging, and there were significant differences in portal vein flow velocity, extrahepatic bile duct diameter and splenomegaly (P<0.05). The main specific manifestations of liver histopathology in PSVD patients were portal occlusion, nodular regenerative hyperplasia, incomplete septal cirrhosis/fibrosis, etc. The non-specific manifestations were fine bile duct reaction fine bile duct reaction and liver tissue inflammatory activity grading and liver fibrosis stage (GS) ≤ G2S2 (33,73.33%).Conclusion:There are certain differences in disease characteristics and similarities between PSVD and LC, and the diagnosis still needs to be made in conjunction with liver pathology on the basis of routine investigations.
Iron(III) extraction from sulfate solutions with D2EHPA in the presence of organic proton-donor additives
Authors: Grigorieva Natalya , Fleitlikh Isaac , Logutenko Olga 
Published: June 2023

Abstract
The effect of organic proton-donor additives (HA) on the extraction of iron(III) from sulfuric acid solutions with di(2-ethylhexyl)phosphoric acid (HR) in decane and toluene was studied. It was shown that adding the additives into the organic phase causes an antagonistic effect. Iron(III) extraction in the presence of additives decreases in the series octyl alcohol ≈ 4-tert-butyl phenol > octanoic acid. The low activity of octanoic acid is attributed to self-association and the formation of dimers in the organic phase, which significantly prevents the formation of intermolecular associates between D2EHPA and monocarboxylic acid. Octanol and 4-tert-butyl phenol form stable associates with D2EHPA leading to a decrease in the ferric iron extraction efficiency thus facilitating efficient iron stripping from the loaded organic phase. In the D2EHPA and octyl alcohol system [FeR2·HR2] is formed. The stripping of iron from the HR and octyl alcohol mixtures was shown to be much more efficient than that from D2EHPA alone and can be successfully achieved using ~4.5 mol/L H2SO4 or H2SO4 (~3.5 mol/L) and NaCl (1.0 mol/L) mixture. Extraction systems containing D2EHPA and aliphatic alcohols can be used to recover iron from various industrial solutions, in particular, from those derived from zinc, nickel production, and others.
Development of a TaqMan-Probe-based multiplex real-time fluorescence quantitative PCR for simultaneous detection of three bovine diarrhea- associated viruses
Authors: Kang Taisheng , Tang Pan , Wang Dongfang , Liu Ying , Zhao Xueli , Xie Caihua , Ma Zhenyuan , Wang Shujuan , Hu Yufeng , Li Bowen , Zhou Jianhao , Feng Guidan , Yan Ruoqian 
Published: June 2023

Abstract

Background
Since the recent discovery, the prevalence of novel bovine diarrhea viruses, including bovine rotavirus virus (BRV), bovine viral diarrhea virus 1 (BVDV-1), and bovine enterovirus virus (BEV) is high worldwide, resulting in significant economic losses to the bovine industry in China. However, clinical symptoms caused by BRV, BVDV-1, and BEV are hard to distinguish, so a rapid and sensitive detection method is urgently needed to differentiate these three viruses. In this study, a real-time fluorescence quantitative-PCR (fqPCR) assay with specific primers and TaqMan fluorescent probes using multiple TaqMan probes for the simultaneous detection of BRV, BVDV-1, and BEV was established.
Result
This assay had good specificity and no cross-reactivity with BPV, BCOV, BNoV, BKoV, and BoAstV. The detection limit of single and multiplex fqPCR was up to 10 copies and correlation coefficients (R2 > 0.992) in all cases, indicating that the method had good sensitivity and repeatability. Clinical detection of samples revealed a 48.4% (34/165) total rate of co-infection among the viruses and a 1.2% (2/165) triple infection rate.
Conclusion
The newly developed multiplex fqPCR assay can serve as a diagnostic tool for BRV, BVDV-1, and BEV identification, and it may be utilized for routine surveillance of these emerging and reemerging bovine diarrheal viruses.
SynK-OR: The synergy of Knowledge Graphs and Ontologies in Conversational Recommendations
Authors: Venkatesh Pruthvi Raj , P Radha Krishna 
Published: June 2023

Abstract
Conversational recommendation systems(CRS) are an increasingly popular way to recommend products, services, or information to users naturally and interactively. These systems use natural language processing and machine learning techniques to understand user preferences, context, and intent and provide personalized recommendations through a dialogue. Though there have been significant enhancements in CRS, there are still shortcomings, such as context awareness, cold start, and data bias. In this paper, we present a novel approach called Synergy of Knowledge Graph and Ontologies in Conversation Recommendations(SynK-OR) that uses multimodal knowledge graphs to store data and user preferences, an ontology for the structural representation of data, and a context builder to store user context. The proposed novel approach introduces a dynamic query generator (DQG) that generates recommendation queries using ontology and user context for content-based filtering. The most notable novelty in the proposed approach involves depicting the user preferences in a knowledge graph as a product of interest and the use of node similarity between the filtered products and user preferences for a well-refined re-ranked recommendation. Our approach can provide recommendations based on collaborative and content-based filters. We have tested our approach on the movie domain from the movie lens dataset[1] using Neo4J[2] as a knowledge graph and Neo4J graph data science(GDS) library[3] for node similarity. Though the paper talks about the entertainment domain, the same approach can be applied to other fields by changing the domain ontology.
Pharmacogenomics knowledge within Neurology: A brief survey amongst physicians
Authors: Narasimhalu Kaavya , Soo Joel , Shen Jia Yi , Wong Pei Shieen 
Published: June 2023

Abstract
Pharmacogenomics has emerged as a tool to optimise treatment. Many neurologists encounter drugs with pharmacogenomic associations with unclear guidelines. We therefore aimed to determine the knowledge, attitudes, and barriers to implement pharmacogenomics in clinical practice within a neurology unit. We developed and administered a survey on pharmacogenomics to physicians working in a neurology unit. Three drug-gene pairs clinically relevant to neurology were presented as case scenarios to assess physicians’ perceived competency, attitudes, and risks towards pharmacogenomics. Thirty-two (27.4%) physicians responded to the survey. Respondents were most confident about activities involving the HLA-B*15:02 test, followed by the CYP2C19 test, and lastly the CYP2C9 test. However, perceived competency in drug-drug-gene-interactions was consistently low for all three tests. Referring to the product information leaflet ranked highest in usefulness, followed by local practice guidelines. In conclusion, local clinical guidelines and training on the clinical applications of pharmacogenomics are important to facilitate implementation of pharmacogenomics.
Pan-cancer analysis of the cuproptosis-related gene DBT that serves as an immunotherapy and prognostic biomarker
Authors: Cui Yue , Wang Hongzhi , Sai Fengying , Yang Shuang , Song Ye , Meng Qingxin , Zhang Fengxia , Yu Dejun 
Published: June 2023

Abstract
Background
Recently, it has been reported that Dihydrolipoamide Branched Chain Transacylase E2 (DBT) is one of the genes related to protein acylation in the process of cuproptosis. However, the role of DBT in pan-cancer and its regulatory mechanism remains unclear.
Methods
In the current study, we used a variety of public bioinformatics platforms to first verify the expression of DBT in tumor and normal tissues, and then further analyze the relationship between DBT expression in tumor and the prognosis of cancer patients, and explore the mechanism of action at the molecular level. After that, the effect of DBT expression on tumor immune microenvironment in pan-carcinoma was discussed. Finally, functional enrichment analysis of DBT related genes was performed.
Results
We found that DBT was significantly down-regulated in most cancer types, and upregulated DBT predicted poor overall survival (OS) for patients in pancreatic adenocarcinoma (PAAD), good OS and disease free survival (DFS) for patients in kidney renal clear cell carcinoma (KIRC), and poor DFS for patients in bladder urothelial carcinoma(BLCA). Further DBT molecular level research showed that the genetic alteration of DBT showed a poor prognosis in BLCA, ESCA and acute myeloid leukemia patients, and the promoter methylation level of DBT was also significant changes in multiple tumors. We found that the expression of DBT was significantly positively related with immune infiltration level in diverse cancer types, and the enrichment analysis showed that DBT related genes were related to protein metabolism and related enzyme stability.
Conclusion
DBT could be an immunotherapy and prognostic biomarker in multiple cancers.
Design of a Ultra-Wide-Band Duplexer without Magnet and Ferrite
Authors: BOUJEMAA Mohamed Ali , Mejri Fethi , Choubani Fethi 
Published: June 2023

Abstract
In this paper, we investigate the design, study, and implementation of an ultra-wideband duplexer. The device we developed is based on microstrip technology and does not require ferrite or other magnetic materials. Its structure includes a wideband Wilkinson power divider and a low-gain radio-frequency amplifier that uses an inexpensive and readily available BFR91A bipolar transistor , making it easy to fabricate and integrate into low-power systems such as radio-frequency chips. The effectiveness of the proposed design has been evaluated through experimental measurements using a vector network analyzer.
Mechanism of laser induced self-organized void array formation in Polydimethylsiloxane (PDMS)
Authors: Naseri Neda , Alshehri Ali , Ramunno Lora , Bhardwaj Ravi 
Published: June 2023

Abstract
This study investigated the formation of multi-voids in polydimethylsiloxane (PDMS) using a multi-pulse irradiation method and explored the impact of laser energy, number of pulses per micron (writing speed), and laser spot size on the process. The experimental results revealed that multi-void formation occurred due to multi-pulse irradiation in the bulk of PDMS. Additionally, increasing laser energy led to an increase in the number of voids, while the number of voids did not change with an increase in the number of pulses per micron for a fixed laser parameter. However, the size of the voids increased with the number of pulses per micron, and tighter focusing conditions resulted in smaller voids with a shorter distance between them.Furthermore, Finite-Difference-Time-Domain (FDTD) simulations reproduced the generation of void arrays in PDMS using a similar multi-laser pulse approach. By modeling the voids as concentric spheres with densified shells and simulating the laser interaction with the voids, we showed that void array generation in PDMS is a linear mechanism. This study provides valuable insight into the mechanism behind the formation of void arrays in PDMS. The simulation results agree with the experimental results to further validate the model and gain a better understanding of the physical processes involved in the generation of void arrays in PDMS.
Terbinafine resistance is associated with newly developed point mutations in squalene epoxidase gene in Trichophyton rubrum and T. mentagrophytes/T. indotineae species complex
Authors: Mohammadi Leila Zahedi , Shams-Ghahfarokhi Masoomeh , Salehi Zahra , Razzaghi-Abyaneh Mehdi 
Published: June 2023

Abstract
The prevalence of dermatophytosis has increased in recent years due to a rise in resistance of etiologic dermatophytes to terbinafine which could be attributed in part to point mutation in the squalene epoxidase (SQLE) gene. In this study, the point mutation in the SQLE gene was studied in Trichophyton rubrum and T. mentagrophytes/T. indotineae species complex as two main causative agents of dermatophytosis. Antifungal susceptibility of clinical isolates of T. rubrum (n = 27) and T. mentagrophytes/T. indotineae (n = 56) was assessed using the M38-3rd edition CLSI method. The SQLE gene and ITS region were sequenced in all the fungal strains, and terbinafine resistant strains were characterized by mutation sites and the genotype. The results demonstrated that in T. rubrum, the minimum inhibitory concentration of terbinafine, was 0.03 µg/ml and GM was equal to 0.02. In T. mentagrophytes complex, MIC50 and MIC90 were 0.03 and 1.0 µg/ml and GM was equal to 0.04 µg/ml. Four out of five resistant strains were T. indotineae harboring the mutations F397L and Q408L; while the last one was T. mentagrophytes genotype VII which harbors the F397L mutation. T. indotineae was the prominent causative agent of terbinafine resistance with 80% of isolates and T. mentagrophytes genotype VII was introduced as a new genotype in terbinafine resistance T. mentagrophytes complex. Our findings further substantiate the importance of antifungal susceptibility testing in selecting the choice drug for effective treatment of dermatophytosis and highlight the importance of screening dermatophyte species for point mutations responsible for newly developed resistance strains to improve current knowledge to overcome infections caused by resistant species.
Do urban green ecological networks have the capacity to store higher levels of carbon?
Authors: Wan Yunshan , Wang Yilei , Gao Ming , Jin Lin 
Published: June 2023

Abstract
Carbon-neutral growth is a crucial long-term climatic aim in the context of global warming. This paper introduces complex network theory and explores its potential application to achieve this goal. Specifically, we investigate the spatial and temporal distribution of nodes and sources in the ecological network, and examine whether a relationship between the topological index of network nodes and the landscape pattern index of ecological source areas exists. We also determine the contribution of nodes to the carbon stock of the entire network by exploring the correlation between the carbon stock of nodes and sources, in order to develop an optimization strategy based on the synergistic effect of node-source carbon enhancement. Finally, we test the effect of network optimization through robustness. Our results show that (1) The correlation topological feature index analysis reveals that the degree distribution of the node network's topological characteristics becomes dispersed and modular, exhibiting the characteristics of small-world networks according to a large clustering coefficient. The heterogeneity and extent of ecological source landscapes have increased by modularity index, but remain distributed and locally fragmented. (2) According to correlation analysis, by enhancing the eccentricity of the node topology, the patch cohesion index (COHESION) of the ecological source site can maximize the contribution of the node to the enhancement of the carbon stock benefits of the source site. (3) According to the tests on the robustness of nodes and edges, and the robustness of network links, network stability is improved and carbon sink capacity is enhanced. Simultaneously, the restoration and rejuvenation of ecological space through national ecological construction projects can effectively improve the carbon sink within the organised region, contributing to the carbon neutrality aim. This research gives scientific and quantifiable references for potential ecological construction projects for sustainable cities and the optimisation of urban ecological space structure.
Impact of transgenic Bt soybean (Cry1Ac) on the biological and reproductive cycle and the hervibory ability of Spodoptera cosmioides (Walker) and Spodoptera eridania (Stoll) (Lepidoptera: Noctuidae)
Authors: Lutz Alejandra Liliana , Fernandez Laura Noemí , Ruiz Verónica Eugenia , Curis María Cecilia , Buttarelli Melina Soledad , Sánchez Pablo Daniel , Favaro María Alejandra , Scotta Roberto Ricardo 
Published: June 2023

Abstract

The Spodoptera cosmioides (Walker) and Spodoptera eridania (Stoll) populations have increased in the central soybean crop zone of Argentina during the last years. Besides being polyphagous, these species are tolerant to the insecticidal toxin Cry1Ac, which is expressed by genetically modified Bt soybeans. The aim of this study was to determine the effect of Bt soybeans on the consumption, biological cycle and reproduction of both Spodoptera species. The Cry1Ac protein had not consequences in the biological and reproductive cycle of S. cosmioides, except in the pupal period duration. It was not observed the same response in S. eridania, which recorded a shorter duration of the larval and adult stages, total cycle and oviposition period. However, both species of Lepidoptera completed their reproductive cycle successfully and the herbivorous ability was not altered. The genetically modified soybean with the event MON89788xMON87701 that expresses the Cry1Ac protein does not control S. cosmioides and S. eridania, and farmers must appeal to chemical control with insecticides when high densities occur in the field. The results obtained in this work are very useful to understand the biology of these species, which have the potential to become important pests in Bt soybean crops in Argentina.
Altered EEG patterns in individuals with disorganized attachment: an EEG microstates study
Authors: Carbone Giuseppe Alessio , Michel Christoph M. , Farina Benedetto , Adenzato Mauro , Ardito Rita B. , Imperatori Claudio , Artoni Fiorenzo 
Published: June 2023

Abstract
Background: Over the past years, different studies provided preliminary evidence that Disorganized Attachment (DA) may have dysregulatory and disintegrative effects on both autonomic arousal regulation and brain connectivity. However, despite the clinical relevance of this construct, few studies have investigated the specific alterations underlying DA using electroencephalography (EEG). Thus, the main aim of the current study was to extend the scientific literature on the EEG microstates correlates of DA in a non-clinical sample (N= 50) before and after the administration of the Adult Attachment Interview (AAI).
Methods: Two EEG Resting State (RS) recordings were performed before and after the AAI. Microstates indices were then calculated using Cartool software.
Results: the Disorganized/Unrevolved (D/U) group showed a lower mean duration of map E and a higher occurrence of map F than the organized individuals. Then, an effect of time also emerged for the microstates indices. Finally, a positive and significant correlation between mean duration of map E post-AAI and coherence of mind was found as well as a negative and significant correlation with segmentation density of map F post-AAI.
Conclusion: our results showed significant differences in the EEG dynamic patterns of mean duration of map E and segmentation density of map F between groups, and a time effect reflecting disintegration mechanisms after retrieval of attachment memories.
Antecedent climate drives divergent, long-term restoration outcomes in the Western Great Plains, USA.
Authors: Barnard david , Macdonald Jacob , Green Tim , Erskine Robert , Mahood Adam 
Published: June 2023

Abstract

Converting croplands to grasslands can restore ecosystem functions and services. But there is uncertainty about why some restoration treatments succeed and others do not. Existing restoration strategies tailor species compositions of seed mixes according to mean conditions in hardiness zones. But individual years typically deviate from average climate norms such that restoration activities may be better informed by recent conditions than with climate averages in order to best direct management strategies. We monitored a field in eastern Colorado that was converted from wheat-fallow to native perennial grassland via seeding. The same seed mix was used to seed half the strips in 2013 (drier) and the other half in 2014 (wetter). The strips seeded in 2013 had only one native grass and shrub species from the seed mix establish, whereas in 2014 all native grasses established Higher soil moisture preceding seed application was positively associated with perennial grasses, while rhizomatous grasses, shrubs and introduced annuals were associated with other variables. We found evidence of facilitatory interactions between grasses and forbs, and antagonistic interactions between native perennial grasses and introduced annuals. These findings can assist land managers to improve upon current approaches by considering antecedent conditions during restoration planning.
Development and Evaluation of Paddy Straw and Wheat Chaff Filter Socks for Stormwater Management
Authors: Shukla Prashant , Siag Mukesh , Kaur Samanpreet , Thaman Sudhir 
Published: June 2023

Abstract
The present study was conducted to evaluate the effectiveness of paddy straw and wheat chaff filter socks for removing suspended sediments from canal water and stormwater runoff. The filter socks of three different diameters of 15, 22.5 and 30 cm; three densities classified as low, medium and high and fixed length of 120 cm were prepared. The flow rate per unit depth of water of filter socks varied between 0.07-0.08 lps/unit head. The total suspended solids removal efficiency of filter socks was up to 65%. There was a little impact on other quality parameters of TDS, pH, EC, BOD, COD and E. coli as these values remained relatively unchanged between inlet and outlet samples. The life of filter socks ranged between 44-56 hours in case of an inlet water TSS load of less than 300 ppm, which drastically reduced to less than 14 hours when the inlet water TSS load increased beyond 700 ppm. Based on the findings, it was recommended that paddy straw filter sock of 30 cm diameter, with medium to high density range of 55.81 to 69.76 kg/m 3 , can be effectively used for reducing the suspended load from runoff. Overall, the study suggests that filter socks made from agricultural waste materials such as paddy straw and wheat chaff can be a viable and sustainable stormwater management technique. They offer low-cost alternative to traditional stormwater management practices and have the added benefit of utilizing agricultural waste that would otherwise go to waste.