bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimisation of Preventive Maintenance Regime and Spare Part Inventory based on Failure Mode System Modelling
Authors: Alamri Theyab O. , Mo John P.T. 
Published: August 2023

Abstract
Preventive maintenance schedules are increasingly important in today's complex and diverse production systems as they help to ensure the continuous operation of systems and reduce overall maintenance costs. This paper presents a novel method for designing a preventive maintenance schedule and spare parts inventory based on failure modes for complex systems with multiple components, using the Failure Modes and Effects Analysis (FMEA) method. The objective is to ensure the continuity of system outputs by modeling subsystems and components as parallel and series arrangements, and using a genetic algorithm to determine the optimal replacement intervals and spare parts inventory based on failure modes. In addition to ensuring the continuity of production outputs during maintenance activities, the approach is also useful in reducing system maintenance costs and increasing system reliability. The proposed approach is applied to a packaging system, and the effects of changing lead time, preventive replacement intervals, and production lost costs on the optimal policy are also examined. The proposed approach is expected to improve system reliability, reduce maintenance costs, and be applicable to any type of complex system at any stage of its development.
Functional near-infrared spectroscopy-based neurofeedback training induces changes in cortico-striatal functional connectivity: A proof of concept study
Authors: Godet Ambre , Serrand Yann , Léger Brieuc , Moirand Romain , Bannier Elise , Val-Laillet David , Coquery Nicolas 
Published: August 2023

Abstract

Due to its central role in cognitive control, the dorso-lateral prefrontal cortex (dlPFC) has been the target of multiple brain modulation studies. In the context of the present pilot study, the dlPFC was the target of 8 repeated neurofeedback (NF) sessions with functional near infrared spectroscopy (fNIRS) to assess the brain response during NF and with functional and resting state magnetic resonance imaging (task-based fMRI and rsMRI) scanning. Fifteen healthy participants were recruited. Cognitive task fMRI and rsMRI were performed during the 1st and the 8th NF sessions. During NF, our data revealed an increased activity in the dlPFC as well as in brain regions involved in cognitive control and self-regulation learning (pFWE < 0.05). Changes in functional connectivity between the 1st and the 8th session revealed increased connectivity between the posterior cingulate cortex and the dlPFC, and between the posterior cingulate cortex and the dorsal striatum (pFWE < 0.05). Decreased left dlPFC-left insula connectivity was also observed. Behavioural results revealed a significant effect of hunger and motivation on the participant control feeling and a lower control feeling when participants did not identify an effective mental strategy, providing new insights on the effects of behavioural factors that may affect the NF learning.
PET/CT Radiomics Integrated with Clinical Indexes as A Tool to Predict Ki67 in Breast Cancer: A Pilot Study
Authors: Ding Hui , Li Yan , Liang Ting , Liao Yuting , Yu Xiao , Duan Xiaoyi , Shen Cong 
Published: August 2023

Abstract

Background: Breast cancer (BC) represents the second cause of cancer-related death among women globally, and Ki67 was demonstrated as an important predictive biomarker in worse survival and neoadjuvant treatment in BC. This study aims to investigate the value of radiomics features derived from18F-FDG PET/CT combined with clinical characteristics in predicting Ki67 in patients with BC. Methods: A total of 114 patients diagnosed as BC and examined using18F-FDG PET/CT were included in this study. Patients were randomly separated into a training set (n = 79, with 55 cases of Ki67 + and 24 cases of Ki67-) and a validation set (n = 35, with 24 cases of Ki67 + and 11 cases of Ki67-) at a ratio of 7:3. Thirteen clinical characteristics and 704 radiomics features were extracted, and the univariance logistic analysis, max-Relevance and Min-Redundancy, the least absolute shrinkage and selection operator regression, and the Spearman test were applied for feature selection. Three models were developed, including the clinical model, the radiomics model, and the combined model, and a nomogram of the combined model was constructed. The predictive performance of all three models was examined by the receiver operating characteristic (ROC) curve. Clinical utility was validated by decision curve analysis (DCA). Results: The N stage, tumor morphology, maximal standard uptake value, and the longest diameter were significantly different in Ki67 + and Ki67- groups (P < 0.05) and were selected as the most discriminative clinical features. Eight radiomics features were selected for the radiomics model. In total, 7 radiomics and the above 4 clinical characteristics were selected for the combined model. The AUC of the combined model in the training and test group was 0.90 (95% Confidence Interval (CI): 0.82–0.97) and 0.81 (95% CI: 0.64–0.99), respectively. The combined model significantly outperformed the radiomics model and the clinical model alone (P < 0.05). The DCA curve showed the advantages of the combined model over the clinical model and radiomics model. Conclusions: The radiomics-derived features combined with the clinical features could effectively predict Ki67 expression in BC based on PET/CT images. Trial registration: This study was registered at ClinicalTrials Gov (number NCT05826197) on 7th, May 2023.
Enhanced osteochondral repair by leukocyte-depleted platelet-rich plasma in combination with adipose-derived mesenchymal stromal cells encapsulated in a three-dimensional photocrosslinked injectable hydrogel in a rabbit model
Authors: Iseki Tomoya , Rothrauff Benjamin B. , Kihara Shinsuke , Overholt Kalon J. , Taha Tarek , Lin Hang , Alexander Peter G. , Tuan Rocky S. 
Published: August 2023

Abstract

Introduction:Intra-articular injection of adipose-derived mesenchymal stromal cells (ASCs) and/or platelet-rich plasma (PRP) have been reported to independently and synergistically improve healing of osteochondral lesions in animal models. However, their independent and combined effects when localized to an osteochondral lesion by encapsulation within a photocrosslinkable methacrylated gelatin hydrogel (GelMA) have not been explored. Herein we investigated a unique combination of allogeneic ASCs and PRP embedded in GelMA as a single-stage treatment for osteochondral regeneration in a rabbit model.Methods:Thirty mature rabbits were divided into six experimental groups: (1) Sham; (2) Defect; (3) GelMA; (4) GelMA + ASCs; (5) GelMA + PRP; and (6) GelMA + ASCs + PRP.At 12 weeks following surgical repair, osteochondral regeneration was assessed on the basis of gross appearance, biomechanical properties, histological and immunohistochemical characteristics, and subchondral bone volume.Results:In terms of mechanical property reflecting the ability of neotissue to bear stress, PRP only group were significantly lower than the Sham group (p = 0.0098). On the other hand, ASCs only and ASCs combined with PRP groups did not exhibit significantly difference, which suggesting that incorporation of ASCs assists in restoring the ability of the neotissue to bear stresses similarly to native tissue (p= 0.346,p= 0.40, respectively). Safranin O in ASCs combined with PRP group was significantly higher than the Defect and GelMA only groups (p= 0.0009,p= 0.0017, respectively). Additionally, ASCs only and ASCs combined with PRP groups presented especially strong staining for collagen type II. Surprisingly, PRP only and PRP + ASCs groups tended to exhibit higher collagen type I and collagen type X staining compared to ASCs only group, suggesting a potential PRP-mediated hypertrophic effect.Conclusion:Regeneration of a focal osteochondral defect in a rabbit model was improved by a single-stage treatment of a photocrosslinked hydrogel containing allogenic ASCs and autologous PRP, with the combination of ASCs and PRP producing superior benefit than either alone. No experimental construct fully restored all properties of the native, healthy osteochondral unit, which may require longer follow-up or further modification of PRP and/or ASCs characteristics.
Automated mood disorder symptoms monitoring from multivariate time-series sensory data: Getting the full picture beyond a single number.
Authors: Corponi Filippo , Li Bryan , Anmella Gerard , Mas Ariadna , Pacchiarotti Isabella , Valentí Marc , Fullana Iria Grande i , Benabarre Antonio , Garriga Marina , Vieta Eduard , Lawrie Stephen , Whalley Heather , Hidalgo-Mazzei Diego , Vergari Antonio 
Published: August 2023

Abstract

Mood disorders (MDs) are among the leading causes of disease burden worldwide. Limited specialized care availability remains a major bottleneck thus hindering pre-emptive interventions. MDs manifest with changes in mood, sleep, and motor activity, observable in ecological physiological recordings thanks to recent advances in wearable technology. Therefore, near-continuous and passive collection of physiological data from wearables in daily life, analyzable with machine learning (ML), could mitigate this problem, bringing mood disorders monitoring outside the clinician’s office. Previous works predict a single label, either the disease state or a psychometric scale total score. However, clinical practice suggests that the same label may underlie different symptom profiles, requiring specific treatments. Here we bridge this gap by proposing a new task: inferring all items in HDRS and YMRS, the two most widely used standardized scales for assessing MDs symptoms, using physiological data from wearables. To that end, we develop a deep learning pipeline to score the symptoms of a large cohort of MD patients and show that agreement between predictions and assessments by an expert clinician is clinically significant (quadratic Cohen’s κ and macro-average F1 score both of 0.609). While doing so, we investigate several solutions to the ML challenges associated with this task, including multi-task learning, class imbalance, ordinal target variables, and cross-subject invariant representations. Lastly, we illustrate the importance of testing on out-of-distribution samples.
Correlation between salivary cytokine profiles and white spot lesions in adolescent patients receiving clear aligner orthodontic treatment
Authors: Luo Houzhuo , Guo Tao , Dang Wei , Song Zhixin , Wen Yi , Jin Zuolin , Liu Qian , Wang Axian 
Published: August 2023

Abstract
Background
To explore the relationship between changes in salivary cytokine levels and the occurrence of white spot lesions in adolescents receiving clear aligner orthodontic treatment and investigate the predictive value of various factors for lesion occurrence.
Methods
68 adolescent patients who received clear aligner orthodontics in our hospital were randomly divided into two groups according to the occurrence or aggravation of white spot lesions after treatment. The general condition of the oral cavity was analyzed, saliva was collected, and inflammation-related cytokines with varying transcription levels between groups were screened by transcriptome analysis. The expression levels of inflammatory cytokines in the saliva of the patients in the two groups were measured, and the risk factors for white spot lesions were screened by correlation analysis and binary logistic regression analysis. The value of the independent and combined application of risk factors for predicting the occurrence of white spot lesions in adolescent patients after invisible orthodontic treatment was analyzed by receiver operating characteristic (ROC) curve analysis.
Results
Transcriptome and GO and KEGG pathway analyses showed that there were differences in the transcription levels of inflammatory cytokines such as CXCL1, CXCL2, CXCL8, CCL3, CCL4, IL-1 β and IL-2 between groups. The levels of CXCL8, CCL3, CCL4, IL-1 β and IL-2 in the saliva of patients with white spot lesions were significantly higher in patients after invisible orthodontic treatment (P < 0.05). Correlation analysis and binary logistic regression analysis showed that elevated levels of CXCL8, IL-1β and IL-2 were independent risk factors for the occurrence of white spot lesions (P < 0.05). CXCL8 had the highest independent predictive value for the occurrence of white spot lesions (AUC = 0.773, P < 0.05), and the combination of IL-1β and IL-2 was also of high value in predicting the occurrence of white spot lesions.
Conclusion
After invisible orthodontic treatment, the oral microenvironment, including inflammatory cytokine levels, in adolescent patients changes; in particular, the levels of inflammatory cytokines such as CXCL and IL change. CXCL8 expression is significantly associated with the occurrence of white spot lesions and is an important potential target for the prevention and treatment of white spot lesions in the future.
Refractive error prevalence, effective refractive error coverage and spectacle coverage among school children in Telangana, South India
Authors: Khanna Rohit , Prakash Winston , Marmamula Srinivas , Keeffe Jill 
Published: August 2023

Abstract
Background
Refractive error (RE) is one of the leading causes of childhood vision impairment. Increasing effective refractive error coverage (e-REC) is one of the main goals of WHO’s 2030 global eye health targets. The aim of this study is to estimate the prevalence of RE, e-REC, risk factors and spectacle coverage among school children in Telangana, South India.
Methods
School children aged 4-15 years in the study locations underwent vision screening using 6/12 tumbling E optotype by trained community eye health workers in the schools. Those failing the initial vision screening and/or found to be having eye conditions were referred to a nearby referral centre appropriately, where they underwent detailed eye examination.
Results
A total of 774 184 children were screened in schools of which 51.49% were boys. The mean age was 9.40 ± 3.27 years. The prevalence of RE was 1.44% (95%CI:1.41-1.46) of which myopia was 1.38% (95%CI: 1.35-1.41). In multivariate analysis, the risk of myopia was higher among older children (Adj.OR: 17.04; 95%CI: 14.64-19.85), those residing in urban areas (Adj.OR:3.05, 95%CI:2.60-3.57), those with disabilities (Adj.OR:2.61, 95%CI:2.00-3.39) and among girls (Adj.OR:1.30, 95%CI:1.25-1.35) (P=0.00). The overall e-REC was 56.97% and the spectacle coverage was 62.83%.
Conclusion
Myopia being the most common type of RE, the risk factors included increasing age, urban location, and presence of disability. The need for interventions to improve e-REC to achieve 2030 global eye health target is also eminent among children in this region.
Smokeless and Combustible Tobacco Use Among 148,944 South Asian Adults: a Cross-Sectional Study from the South Asia Biobank
Authors: Xie Wubin , Mridha Malay Kanti , Gupta Anaya , Kusuma Dian , Butt Awais , Hasan Mehedi , Brage Soren , Loh Marie , Khawaja Khadija Irfan , Pradeepa Rajendra , Jha Vinita , Kasturiratne Anuradhani , Katulanda Prasad , Anjana Ranjit Mohan , Chambers John C 
Published: August 2023

Abstract
Background
Tobacco use, in both smoking and smokeless forms, is highly prevalent among South Asian adults. The aims of the study were twofold: 1) describe patterns of SLT and combustible tobacco product use in four South Asian countries stratified by country and sex, and 2) assess the relationships between SLT and smoking intensity, smoking quit attempts, and smoking cessation among South Asian men.
Methods
Data were obtained from South Asia Biobank Study, collected between 2018 and 2022 from 148,944 men and women aged 18 years and above, living in Bangladesh, India, Pakistan, or Sri Lanka. Mixed effects multivariable logistic and linear regression were used to quantify the associations of SLT use with quitting smoking attempt, cessation, and intensity.
Results
Among the four South Asian countries, Bangladesh has the highest rates of current smoking (39.9% for male, 0.4% for female) and current SLT use (24.7% for male and 23.4% for female). Among male adults, ever SLT use was associated with a higher odds of smoking cessation in Bangladesh (OR, 2.88; 95% CI, 2.65, 3.13), India (OR, 2.02; 95% CI, 1.63, 2.50), and Sri Lanka (OR, 1.36; 95% CI, 1.14, 1.62). Ever SLT use and current SLT use was associated with lower smoking intensity in all countries.
Conclusions
In this large population-based study of South Asian adults, rates of smoking and SLT use vary widely by country and gender. Men who use SLT products are more likely to abstain from smoking compared with those who do not.
Association of childhood socio-economic status and health with depressive symptoms among older adults in India
Authors: Khanal Gayatri , Selvamani Y. 
Published: August 2023

Abstract
Background
Childhood adverse experience has been linked with poor health outcomes across the life course. Nevertheless, whether such an association or direction could be projected to older people’s life remains still unclear and needs to generate more evidence, particularly in India. Therefore, this study was conducted to examine the association of childhood socio-economic status and health with depressive symptoms amongst older adults in India.
Methods
Cross-sectional study from the first wave of the national representative survey “Longitudinal Ageing Study in India (LASI)” was used. Multivariable regression analysis was used to examine the association of childhood socioeconomic status and health with depressive symptoms in the older population.
Results
Poor childhood health was significantly and positively associated with depressive symptoms (AoR: 1.372, CI: 1.09, 1.727). Likewise, respondents who were bedridden for a month during their childhood had high odds of developing depressive symptoms (AoR: 1.154 CI: 1.008, 1.322). In addition to this, the odds of having depressive symptoms increased significantly among the average (AoR: 1.276 CI: 1.025, 1.588) and poor childhood socioeconomic status group (AoR: 1.259 CI: 1.007, 1.573) as compared to the higher childhood socioeconomic status category.
Conclusions
Childhood socioeconomic status and health have a statistically significant role in determining mental health in later life. Results suggest that considering childhood socioeconomic status and health is important while diagnosing depression in older population in order to identify the significant associated factors in early childhood and thus help in preventing depressive symptoms in later life.
Streamlining the totally extraperitoneal approach for laparoscopic inguinal hernia repair: the 3-2-1 method
Authors: Zhou Xue-Lu 
Published: August 2023

Abstract
Background The total extraperitoneal (TEP) technique is known for its complexity compared to the transabdominal preperitoneal technique (TAPP). This study aimed to streamline the TEP procedure by introducing the 3-2-1 method, which involves creating three surgical planes, implementing two transitions, and establishing a spacious preperitoneal space. The objective was to comprehensively evaluate the safety, efficacy, and reliability of this approach.
Methods A total of 358 patients with 380 inguinal hernias underwent TEP repair using the 3-2-1 method via the retromuscular approach. Patient characteristics, operative time, hospital stay, complications, and recurrence rates were assessed.
Results Among the hernias, 190 were on the right side, 140 on the left side, and 50 were bilateral. The distribution of hernia types included indirect hernia (201), direct hernia (132), compound hernia (16), complex hernia (6), and femoral hernia (3). The average operative time was 58 minutes for unilateral hernias and 110 minutes for bilateral hernias. Postoperative complications occurred in 32 cases (8.9%), but no serious complications were observed. The average hospital stay was 7 days, and patients were followed up for an average of 49 months. There were no cases of chronic pain or recurrence.
Conclusions The 3-2-1 method for laparoscopic TEP repair of inguinal hernias proves to be a simple, safe, effective, and reliable approach.
Process evaluation of school-based high-intensity interval training interventions for children and adolescents: a systematic review and meta-analysis of randomized controlled trials
Authors: Liu Yong , Wadey Curtis A. , Barker Alan R. , Williams Craig A. 
Published: August 2023

Abstract

Background Several systematic reviews have been published to investigate the effectiveness of high-intensity interval training (HIIT) in schools. However, there has been limited attention given to understanding the functioning of the intervention processes, which is of paramount importance for interpreting and translating the intervention effectiveness. The aim of this systematic review is to determine the extent to which process evaluation is measured in school-based HIIT interventions and to explore the effects of process evaluation and intervention characteristics on cardiorespiratory fitness (CRF), body composition, muscular strength, and blood pressure. Methods A comprehensive search was conducted in SPORT Discus (EBSCOhost), Web of Science, Scopus, Medline (Ovid) and Cochrane Central Register of Controlled Trials. The extent to which process evaluation is measured was narratively reported, alongside with the guidance of process evaluation of complex interventions by UK Medical Research Council. Meta-analyses and meta-regressions were conducted to determine the effects of process evaluation and intervention characteristics to the intervention outcomes. Results The literature search identified 77 studies reporting on 45 school-based HIIT interventions. In total, five interventions reported process evaluation in a section or in a separate study, and only one intervention adopted a process evaluation framework. On average, 6 out of 12 process evaluation measures were reported in all interventions. Subgroup analyses did not indicate any beneficial treatment effects for studies with process evaluation group, whereas all pooled data and studies without process evaluation group showed significant improvement for CRF and body composition. Conclusion Process evaluation is frequently omitted in the literature of school-based HIIT in children and adolescents. Although reporting of process evaluation measures may not directly associate with better intervention outcomes, it allows accurate interpretation of intervention outcomes, thereby enhancing the generalisability and dissemination of the interventions.