bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sustainable DNA Data Storage on Cellulose Paper
Authors: Liu Qian , Wei Yanan , Wang Zhaoguan , Song Dong‐Po , Cui Jingsong , Qi Hao 
Published: June 2023

AbstractDNA is a promising material for high density and long‐term archival data storage. In addition to algorithms for encoding digital information into DNA sequences, the DNA writing (chemical synthesis) and reading (DNA sequencing), the preservation of DNA mixtures with high sequence diversity is another critical issue for sustainable, long‐term, and large‐scale DNA data storage. Here, this work demonstrates a method for low‐cost, convenient and sustainable DNA data storage on cellulose paper. A DNA pool comprising thousands of sequences, in which archival data are encoded, is conveniently stored on a cellulose paper with a calculated density as high as 15 TB per mm3 through electrostatic adsorption. This work demonstrates that these digitally encoded DNA pools can be stable for years on the cellulose paper after drying even when directly exposed to air. Furthermore, the reversible electrostatic adsorption enables repeated loading/retrieval of DNA on/off cellulose paper. Therefore, this sustainable DNA preservation on cellulose paper through the convenient electrostatic adsorption exhibits a great advantage in terms of storage capacity and cost that is crucial for practical systems to achieve large‐scale and long‐time data storage.
Western medicine and Japanese Kampo medicine are in a complementary relationship — Stillness and movement are beautifully harmonized in Japanese Kampo medicine
Authors: Tatsumi Koichiro 
Published: June 2023

AbstractObjectiveThis review is a general outline to have a proper understanding of Japanese Kampo medicine from my point of view.BackgroundWhat is the basis of medical care? The answer is how to capture the signals emitted by the living body. In western medicine, diagnosis with a disease name is required for medical therapy to acquire a medical insurance reimbursement. In contrast, in Japanese Kampo medicine pathophysiological diagnosis is required for choosing the proper medication. Western medicine is the science of disease, while Kampo medicine is the science of indication. In other words, western medicine has been searching to find a drug that works, while Kampo medicine has been pursuing how to make medicine work.Present Position of KampoJapanese Kampo medicine originally comes from traditional Chinese medicine as delineated in the Chinese classic medical texts Shokanron and Kinkiyoryaku. This framework was introduced to Japan around the 5th to 6th centuries; after that, while inheriting past experience, repeating verification anew, and progressing in search of new developments, Japanese Kampo medicine has been developing. Kampo medicine has succeeded in combining with the perspective of modern western medicine, and looks for what appropriate therapy is in accordance with the Kampo medical syndromes. Kampo medicine is a harmonious medical practice. To investigate Kampo prescription a little deeper, the medicine is usually broken down into its crude drugs.ConclusionCoexistence with Japanese Kampo medicine fills gaps in western medicine by its complementary approach. For understanding Kampo medicine, both western and Kampo medical understanding of Kampo medicine are required.
Use of haemodiafiltration in the treatment of massive caffeine intoxication in a dog
Authors: Gordon Daniel S. , Langston Cathy E. 
Published: June 2023

AbstractThe objective of this case report is to describe the use of extracorporeal therapy, specifically hemodialfiltration, for the treatment of caffeine intoxication. A 12 year old Border Terrier consumed up to 1440 mg/kg of caffeine and rapidly developed clinical signs of tachycardia and tremors. Hemodiafiltration was instituted, using an M60 PrismaFlex cartridge using blood to prime the system due to patient size. Treatment with 11.25 L of therapy fluid (83% dialysate, 17% replacement fluid), or 1.8 L/kg, was provided over 6 h. Pre‐treatment serum caffeine concentration of 233 µg/mL was decreased by 89% to 25 µg/nL by the end of treatment. Despite prompt institution of extracorporeal toxin removal therapy, ventricular ectopy developed necessitating sotolol treatment for the following week. Caffeine is efficiently removed via hemodialysis, as predicted by small size, small volume of distribution, and minimal protein binding. A CRRT platform can be used to provide adequate clearance.
A review of N‐mixture models
Authors: Madsen Lisa , Royle J. Andrew 
Published: June 2023

AbstractN‐mixture models were born in 2004 of the necessity to model animal population size from point counts with imperfect detection of individuals, where capture‐recapture methods are infeasible. Initially developed for applications where population size was assumed constant, N‐mixture models were extended in 2011 to include population dynamics, allowing application to populations whose size fluctuates during the study. A further extension in 2014 accommodates populations with multiple “states” such as age class or sex. More recent extensions model spatial movement of animals among habitat patches or the spatial spread of infectious disease in a human population. The core idea underlying this class of models is a hierarchical structure, where the observation model is defined conditional on the model for true abundance. This hierarchy allows researchers to incorporate information about observation and abundance processes, while permitting distinct inferences about elements affecting detection and those affecting abundance. Another benefit of the hierarchical approach is the ability to accommodate many existing sampling protocols such as removal sampling and distance sampling. One drawback to N‐mixture models is that since they estimate both abundance and detection from replicated but unmarked counts, model parameters may not be clearly identifiable. A second drawback is that when observed counts are large, calculating the N‐mixture likelihood is computationally infeasible. This difficulty motivated an approximate likelihood based on the normal approximation to the binomial. The normal approximation provides a diagnostic of parameter estimability based on the closed‐form expression of the Fisher information matrix for a multivariate normal likelihood.This article is categorized under:Data: Types and Structure > Image and Spatial DataStatistical Learning and Exploratory Methods of the Data Sciences > Modeling Methods
Radiation Dose and Fluoroscopy Time of Extracranial Carotid Artery Stenting
Authors: Forbrig Robert , Ozpeynirci Yigit , Fischer Thomas David , Trumm Christoph G. , Liebig Thomas , Stahl Robert 
Published: June 2023

Abstract
Purpose
Fluoroscopically guided endovascular carotid artery stenting (CAS) of extracranial carotid stenosis (ECS) is a reasonable alternative to carotid endarterectomy in selected patients. Diagnostic reference levels (DRL) for this common neurointervention have not yet been defined and respective literature data are sparse. We provide detailed dosimetrics for useful expansion of the DRL catalogue.

Methods
A retrospective single-center study of patients undergoing CAS between 2013 and 2021. We analyzed dose area product (DAP) and fluoroscopy time considering the following parameters: indications for CAS, semielective/elective versus emergency including additional mechanical thrombectomy (MT) in extracranial/intracranial tandem occlusion, etiology of ECS (atherosclerotic vs. radiation-induced), periprocedural features, e.g., number of applied stents, percutaneous transluminal angioplasty (PTA) and MT maneuvers, and dose protocol. Local DRL was defined as 75% percentile of the DAP distribution.

Results
A total of 102 patients were included (semielective/elective CAS n = 75, emergency CAS n = 8, CAS + MT n = 19). Total median DAP was 78.2 Gy cm2 (DRL 117 Gy cm2). Lowest and highest median dosimetry values were documented for semielective/elective CAS and CAS + MT (DAP 49.1 vs. 146.8 Gy cm2, fluoroscopy time 27.1 vs. 43.8 min; p < 0.005), respectively. Dosimetrics were significantly lower in patients undergoing 0–1 PTA maneuvers compared to ≥ 2 maneuvers (p < 0.05). Etiology of ECS, number of stents and MT maneuvers had no significant impact on dosimetry values (p > 0.05). A low-dose protocol yielded a 33% reduction of DAP.

Conclusion
This CAS study suggests novel local DRLs for both elective and emergency cases with or without intracranial MT. A dedicated low-dose protocol was suitable for substantial reduction of radiation dose.
Virale Zoonosen in Deutschland aus der One Health-Perspektive
Authors: Ulrich Rainer G. , Drewes Stephan , Haring Viola , Panajotov Jessica , Pfeffer Martin , Rubbenstroth Dennis , Dreesman Johannes , Beer Martin , Dobler Gerhard , Knauf Sascha , Johne Reimar , Böhmer Merle M. 
Published: June 2023

ZusammenfassungCOVID-19-Pandemie und gehäuftes Auftreten von Mpox-Erkrankungen (Affenpocken) außerhalb Afrikas haben die Verletzlichkeit der Bevölkerung für aus dem Tierreich stammende Krankheitserreger deutlich werden lassen. Darüber hinaus haben in den vergangenen Jahren weitere virale Zoonoseerreger an Bedeutung gewonnen.Der vorliegende Übersichtsartikel beleuchtet anhand von 6 meldepflichtigen viralen Zoonoseerregern beispielhaft die Notwendigkeit der One Health-Herangehensweise, um die Epidemiologie der Erkrankungen verstehen zu können und Handlungsempfehlungen für den öffentlichen Gesundheitsdienst abzuleiten. Dabei wird die Bedeutung von Umweltfaktoren, Reservoiren und Vektoren betont, die Erkrankungen bei Nutz- und Wildtieren werden analysiert sowie das Auftreten und die Häufigkeit von Erkrankungen bei der Bevölkerung beschrieben. Die hier ausgewählten Erreger unterscheiden sich in den Reservoiren und der Rolle von Vektoren für die Übertragung, den Auswirkungen der Infektionen auf landwirtschaftliche Nutztiere und den beim Menschen beobachteten Krankheitsbildern. Neben bereits lange in Deutschland bekannten Zoonoseerregern werden auch Erreger betrachtet, die erst kürzlich eingetragen wurden bzw. deren Zoonosepotenzial vor Kurzem erstmals gezeigt worden ist.Bei den hier behandelten Erregern gibt es nach wie vor deutliche Wissenslücken zu den Übertragungswegen. Zukünftige One Health-basierte Untersuchungen werden zu deren weiterer Aufklärung und somit zur Entwicklung von Präventionsmaßnahmen beitragen. Die ganzheitliche Herangehensweise beinhaltet nicht zwangsläufig eine Fokussierung auf virale Erreger/Erkrankungen, sondern beinhaltet auch die Frage der Wechselwirkungen von viralen, bakteriellen und anderen Erregern, inkl. der Antibiotikaresistenz und der Wirtsmikrobiome.
Influence of selective laser melting process parameters on the surface integrity of difficult-to-cut alloys: comprehensive review and future prospects
Authors: Pimenov Danil Yu. , Berti Lucas Freitas , Pintaude Giuseppe , Peres Gustavo Xavier , Chaurasia Yash , Khanna Navneet , Giasin Khaled 
Published: June 2023

AbstractDifficult-to-cut alloys, which include titanium, cobalt, nickel alloys, and high-strength and heat-resistant steels, can nowadays be manufactured using selective melting (SLM), and products made of such materials are widely used in aerospace, automotive, and medical applications. SLM is widely used among other methods of additive manufacturing (AM) for the production of parts with complex geometry which are difficult to produce using conventional manufacturing processes. In this review article, for the first time, a comprehensive literature review of the most important parameters which influence the SLM manufacturing process of difficult-to-cut alloys is discussed and analysed. Parameters such as composition, grain size, defects, texture, and thermo-mechanical properties and their effect on surface integrity, namely surface topography (machined surface defects, surface roughness, surface texture), microstructural alterations (plastic deformation, grain refinement, and orientation, white layer formation), and mechanical properties (work hardening layer formation and microhardness, residual stress) are discussed. As a result, this review article shows the advantages and disadvantages of using various compositions, classifications, microstructure, defects, and properties of SLM of difficult-to-cut alloys on surface integrity and outlines development prospects, challenges, and future trends.
Development and external validation of a multivariable [68Ga]Ga-PSMA-11 PET-based prediction model for lymph node involvement in men with intermediate or high-risk prostate cancer
Authors: Muehlematter Urs J. , Schweiger Lilit , Ferraro Daniela A. , Hermanns Thomas , Maurer Tobias , Heck Matthias M. , Rupp Niels J. , Eiber Matthias , Rauscher Isabel , Burger Irene A. 
Published: June 2023

Abstract
Purpose
To develop and evaluate a lymph node invasion (LNI) prediction model for men staged with [68Ga]Ga-PSMA-11 PET.

Methods
A consecutive sample of intermediate to high-risk prostate cancer (PCa) patients undergoing [68Ga]Ga-PSMA-11 PET, extended pelvic lymph node dissection (ePLND), and radical prostatectomy (RP) at two tertiary referral centers were retrospectively identified. The training cohort comprised 173 patients (treated between 2013 and 2017), the validation cohort 90 patients (treated between 2016 and 2019). Three models for LNI prediction were developed and evaluated using cross-validation. Optimal risk-threshold was determined during model development. The best performing model was evaluated and compared to available conventional and multiparametric magnetic resonance imaging (mpMRI)-based prediction models using area under the receiver operating characteristic curves (AUC), calibration plots, and decision curve analysis (DCA).

Results
A combined model including prostate-specific antigen, biopsy Gleason grade group, [68Ga]Ga Ga-PSMA-11 positive volume of the primary tumor, and the assessment of the [68Ga]Ga-PSMA-11 report N-status yielded an AUC of 0.923 (95% CI 0.863–0.984) in the external validation. Using a cutoff of  ≥ 17%, 44 (50%) ePLNDs would be spared and LNI missed in one patient (4.8%). Compared to conventional and MRI-based models, the proposed model showed similar calibration, higher AUC (0.923 (95% CI 0.863–0.984) vs. 0.700 (95% CI 0.548–0.852)—0.824 (95% CI 0.710–0.938)) and higher net benefit at DCA.

Conclusions
Our results indicate that information from [68Ga]Ga-PSMA-11 may improve LNI prediction in intermediate to high-risk PCa patients undergoing primary staging especially when combined with clinical parameters. For better LNI prediction, future research should investigate the combination of information from both PSMA PET and mpMRI for LNI prediction in PCa patients before RP.
Effect of periprocedural furosemide-induced diuresis with matched isotonic intravenous hydration in patients with chronic kidney disease undergoing transcatheter aortic valve implantation
Authors: Voigtländer-Buschmann Lisa , Schäfer Sarina , Schmidt-Lauber Christian , Weimann Jessica , Shenas Mina , Giraldo Cortes Julian , Kuta Piotr Mariusz , Zeller Tanja , Twerenbold Raphael , Seiffert Moritz , Schofer Niklas , Schneeberger Yvonne , Schäfer Andreas , Schirmer Johannes , Reichenspurner Hermann , Blankenberg Stefan , Conradi Lenard , Schäfer Ulrich 
Published: June 2023

Abstract
Background
Acute kidney injury (AKI) after transcatheter aortic valve implantation (TAVI) is a serious complication which is associated with increased mortality. The RenalGuard system was developed to reduce the risk of AKI after contrast media exposition by furosemide-induced diuresis with matched isotonic intravenous hydration. The aim of this study was to examine the effect of the RenalGuard system on the occurrence of AKI after TAVI in patients with chronic kidney disease.

Methods
The present study is a single-center randomized trial including patients with severe aortic valve stenosis undergoing TAVI. Overall, a total of 100 patients treated by TAVI between January 2017 and August 2018 were randomly assigned to a periprocedural treatment with the RenalGuard system or standard treatment by pre- and postprocedural intravenous hydration. Primary endpoint was the occurrence of AKI after TAVI, and secondary endpoints were assessed according to valve academic research consortium 2 criteria.

Results
Overall, the prevalence of AKI was 18.4% (n = 18). The majority of these patients developed mild AKI according to stage 1. Comparing RenalGuard to standard therapy, no significant differences were observed in the occurrence of AKI (RenalGuard: 21.3%; control group: 15.7%; p = 0.651). In addition, there were no differences between the groups with regard to 30-day and 12-month mortality and procedure-associated complication rates.

Conclusion
In this randomized trial, we did not detect a reduction in AKI after TAVI by using the RenalGuard system. A substantial number of patients with chronic kidney disease developed AKI after TAVI, whereas the majority presented with mild AKI according to stage 1 (ClinicalTrials.gov number NCT04537325).

Graphical abstract
Homelessness and health-related outcomes in the Republic of Ireland: a systematic review, meta-analysis and evidence map
Authors: Ingram Carolyn , Buggy Conor , Elabbasy Darin , Perrotta Carla 
Published: June 2023

Abstract
Aim
To map existing research on homelessness and health in the Republic of Ireland, and to synthesize the evidence on housing-related disparities in health.

Methods
Peer-reviewed articles and conference abstracts published in English between 2012–2022 were retrieved from 11 bibliographic databases if they contained empirical data on homelessness and health in Ireland, and – in a subsequent screening stage – at least one measure of health disparity between the homeless and general populations. Reviewers extracted relative risks (RR), 95% confidence intervals (CI), and calculated pooled RR of comparable health disparities using pairwise random-effects meta-analyses.

Results
One hundred four articles contained empirical data on the health of homeless individuals residing in Ireland, addressing primarily substance use, addiction and mental health. Homelessness was associated with increased risk of illicit drug use (RR 7.33 [95% CI 4.2, 12.9]), reduced access to a general practitioner (GP) (RR 0.73 [CI 95% 0.71, 0.75]), frequent emergency department (ED) presentation (pooled RR 27.8 [95% CI 4.1, 189.8]), repeat presentation for self-harm (pooled RR 1.6 [95% CI 1.2, 2.0]) and premature departure from hospital (pooled RR 2.65 [95% CI 1.27, 5.53]).

Conclusions
Homelessness in Ireland is associated with reduced access to primary care and overreliance on acute care. Chronic conditions amongst homeless individuals are understudied.
Immobilization effects of co-pyrolyzed neem seed mixed with poultry manure on potentially toxic elements in soil and the phytoremediation potentials of native Manihot esculenta and Jatropha curcas in ensuring sustainable land use
Authors: Mensah Martin Kofi , Drebenstedt Carsten , Ola Ibukun Momoriola , Hoth Nils , Damptey Frederick Gyasi , Wiafe Edward Debrah 
Published: June 2023

AbstractThis study evaluated the effects of neem seed biochar, poultry manure, and their combinations at varying rates of 15 and 25% (w/w) on potentially toxic elements (PTEs) in soils. Afterward, the suitability of Manihot esculenta and Jatropha curcas in removing Cd, As, Zn, Pb, and Hg from mine spoils were appraised in a 270-day outdoor pot experiment. Using ICP–Mass Spectrometry, the elemental contents of target PTE in the shoot, root, and soil specimens were determined for each treatment. The obtained average values were further subjected to a nonparametric test of samples using IBM SPSS Statistic 29. The applied organic amendments resulted in significant differences p < 0.05 in PTE availability for plant uptake after the Independent-Samples Kruskal–Wallis Test was made. Nonetheless, applying a 25% (w/w) mixture of neem seed biochar and poultry manure was efficient in immobilizing more PTEs in soils which caused lower PTEs presence in plants. Organic amendments further significantly enhanced the fertility of the mine soils leading to about a 6– 25.00% increase in the biomass yield (p < 0.05) of both plants. No significant difference (p > 0.05) was however observed between the phytoremediation potentials of both plants after the Independent-Sample Mann–Whitney U test. Even that, Manihot esculenta was averagely more efficient in PTE uptake than Jatropha curcas. Larger portions of the bioaccumulated PTEs were stored in the roots of both plants leading to high bioconcentration factors of 1.94– 2.47 mg/kg and 1.27– 4.70 mg/kg, respectively, for Jatropha curcas and Manihot esculenta. A transfer factor < 1 was achieved for all PTEs uptake by both plants and indicated their suitability for phytostabilization. Techniques for easy cultivation of root-storing PTEs are required to enhance their large-scale use as their biomass could further be used in clean energy production.
Epistemic injustice in the therapeutic relationship in psychiatry
Authors: Sakakibara Eisuke 
Published: June 2023

AbstractThe notion of epistemic injustice was first applied to cases of discrimination against women and people of color but has since come to refer to wider issues related to social justice. This paper applies the concept of epistemic injustice to problems in the therapeutic relationship between psychiatrists and psychiatric patients. To this end, it is necessary to acknowledge psychiatrists as professionals with expertise in treating mental disorders, which impair the patient’s rationality, sometimes leading to false beliefs, such as delusions. This paper classifies the characteristic features of the therapeutic relationship in psychiatry into three stages: those of a professional–client relationship, those of a doctor–patient relationship, and those of a psychiatrist–psychiatric patient relationship. Epistemic injustice is prevalent in psychiatric care owing to prejudice against patients with mental disorders. However, it is also predisposed by the roles that psychiatrists play in relation to psychiatric patients. This paper suggests some ameliorative measures based on the analysis.
Determining the severity of Parkinson’s disease in patients using a multi task neural network
Authors: García-Ordás María Teresa , Benítez-Andrades José Alberto , Aveleira-Mata Jose , Alija-Pérez José-Manuel , Benavides Carmen 
Published: June 2023

AbstractParkinson’s disease is easy to diagnose when it is advanced, but it is very difficult to diagnose in its early stages. Early diagnosis is essential to be able to treat the symptoms. It impacts on daily activities and reduces the quality of life of both the patients and their families and it is also the second most prevalent neurodegenerative disorder after Alzheimer in people over the age of 60. Most current studies on the prediction of Parkinson’s severity are carried out in advanced stages of the disease. In this work, the study analyzes a set of variables that can be easily extracted from voice analysis, making it a very non-intrusive technique. In this paper, a method based on different deep learning techniques is proposed with two purposes. On the one hand, to find out if a person has severe or non-severe Parkinson’s disease, and on the other hand, to determine by means of regression techniques the degree of evolution of the disease in a given patient. The UPDRS (Unified Parkinson’s Disease Rating Scale) has been used by taking into account both the motor and total labels, and the best results have been obtained using a mixed multi-layer perceptron (MLP) that classifies and regresses at the same time and the most important features of the data obtained are taken as input, using an autoencoder. A success rate of 99.15% has been achieved in the problem of predicting whether a person suffers from severe Parkinson’s disease or non-severe Parkinson’s disease. In the degree of disease involvement prediction problem case, a MSE (Mean Squared Error) of 0.15 has been obtained. Using a full deep learning pipeline for data preprocessing and classification has proven to be very promising in the field Parkinson’s outperforming the state-of-the-art proposals.