bluuebunny/crossref_metadata_2025_split huggingface dataset:
Determinants of bank profitability in Georgian banking sector
Authors: Mercan Metin , Botsvadze Ilia , Dzagania Bachana , Khoshtaria Tornike , Rachvelishvili Ana 
Published: March 2023

This study examines the impact of bank-specific and macroeconomic determinants on the profitability of commercial banks in Georgia, where banks tend to be the largest part of the financial system, with free market systems and liberalization policies similar to those in other transition economies, using panel data analysis and random forest method (RVI) is implemented as a robustness check. The profitability indicators return on asset (ROA), return on equity (ROE), and net interest margin (NIM), all of which have been extensively utilized as indicators of profitability in previous research, were employed. The research indicates that the three most significant bank-specific factors are net loans, nonperforming loans, and capital adequacy ratios. Other bank-specific factors such as asset size and liquidity ratio have statistically minor effects on bank profitability. The other macroeconomic determinant, inflation rate, has no effect on the profitability performance levels of the banks studied.
Capital Adequacy and Risk Management Issues in Banking before, during and after 2007-2008 Financial Crisises
Authors: Botsvadze Ilia 
Published: March 2023

The paper provides evidence about Basel II, as international banking regulations failure in recent global financial crisis. It describes old and new banking regulations main aspects on the base of before and during financial crisis periods. Banks’ holding of reasonable capital buffers in excess of minimum requirements could alleviate the procyclicality problem potentially exacerbated by the rating-sensitive capital charges of Basel II. Determining the sufficient buffer size is an important risk management task for banks. Actual bank capital is driven by bank income and default losses, whereas capital requirements within Basel II are driven by rating transitions. New regulatory approach to measuring capital adequacy appears consistent with banks’ own risk evaluations. The purpose of the paper is to show Basel II’s role in financial crisis based on qualitative inductive research. Also paper mentions some political aspects of modern banking regulations and future suggestions and recommendations for after crisis banking future.
Analisis Pengembangan Pariwisata di Kecamatan Binuang Kabupaten Polewali Mandar
Authors: Irwan Andi Lukman , Nawawi Juanda , Lia Ayu 
Published: March 2023

This study aims to determine the role of the government in tourism development in the Binuang sub-district, Polewali Mandar Regency, seen from the arrangement and development of tourist objects, the development and development of tourism supporting facilities and infrastructure and the promotion of tourism. The method used in this research is to use a qualitative descriptive research type which aims to describe the problem solving of the research object based on visible facts or data in the field. Data collecting technique is done by interviewing and observing and documentation which includes archives, literature review or literature related to research problems.
The results showed: tourism development in Binuang Subdistrict, Polewali Mandar Regency, seen from the arrangement and development of tourist objects in accordance with the Regional Tourism Development Master Plan by identifying tourist objects that have the potential to focus on development. In addition, coaching activities for tourism managers are also carried out every few months in order to improve the quality and quality of tourism objects. Then, the development and development of tourism facilities and infrastructure carried out by the government can also be seen from the development and maintenance efforts of tourism supporting facilities and infrastructure. Tourism promotion by the Youth Sport and Tourism Agency which is considered quite effective is the Polewali Mandar Festival Fork & Art (PIFAF) which in addition to introducing culture also introduces tourism potentials in Polewali Mandar Regency.
Spirulina platensis effect on oxidative stress of rat’s offspring brain exposed to cigarette smoke during pregnancy and lactation
Authors: Abadi Kenny Cantika , Iswanti Febriana Catur , Jusman Sri Widia A , Fadilah Fadilah , Prijanti Ani Retno 
Published: March 2023

Background: Maternal exposure to cigarette smoke during pregnancy and lactation might harmful for the fetus. The smoke contains many free radicals that could be eliminated by antioxidant. This study aimed to investigate the effect of Spirulina platensis ethanol extract as antioxidant against cigarette smoke exposure during pregnancy until lactation by assessing oxidative stress markers in neonatal brain tissues.
Methods: The experimental study used 26 offspring divided into four groups: (C) = offspring of maternal control group; (Cg) = offspring of maternal exposed to cigarette smoke; (CgSp) = offspring of maternal given spirulina and exposed to cigarette smoke; and (Sp) = offspring of maternal given spirulina only group, during gestation and 9 days lactation (30 days). Each group consisted of 6 offspring obtained from 2 adult females mated with male Sprague-Dawley rats. The exposure of cigarette smoke was 4 burn cigarettes/day for 30 days. The dose of extract was 200 mg/kg BW. The offspring were sacrificed, and the brain tissues were taken for MDA, MnSOD activity, as well as catalase activity, carbonyl, and GSH.
Results: There was no significant differences in MDA level between groups. The carbonyl, SOD, and catalase activity did not differ between the control and smoked group.
Conclusion: Exposure of four burned cigarettes smoke per day during pregnancy, and 9 days of lactation did not trigger oxidative stress. However, the effect of Spirulina platensis administration on rat offspring brain could not be analyzed.
HUBUNGAN LAYANAN PERAWAT DENGAN KEPUASAN PASIEN
Authors: ARIAWAN HIDAYAT SYAHFRIL 
Published: March 2023

Abstract

Introduction : Patient satisfaction is one indicator of success of health services. One of the factors which influences patient satisfaction is nurse services. There are five aspects in providing nurse services, namely attention, acceptance, communication, cooperation, and responsibility.
Objective : The research objective was to determine the relation between nurse services and patient satisfaction in the Edelweiss room at the Islamic Hospital of Malang, UNISMA.
Research methods : This study used the Observational Analytic method with a cross-sectional approach to 52 respondents. Data was collected by using purposive sampling technique from December 2022 to January 2023. The instrument used was a questionnaire sheet and the Statistical test used was Fisher.
Results : Based on the results of the study, from 52 respondents there are 47 respondents (90.4%) states that the nurse service was good and satisfied, while no respondents (0%) states that the nurse service was good, but it is not satisfied, and no respondents (0%) who states that the nurse service was not good but satisfied, while those who states that the nurse service was not good and dissatisfied were 5 respondents (9.6%). From the statistical test which was carried out according to the Fisher Exact Test analysis has obtained the value of p = 0.000 <0.05 . Thus H0 is rejected and H1 is accepted, which means there is a relation between nurse services and patient satisfaction in Edelweiss Room of the Malang Islamic Hospital, UNISMA.
Suggestion : For this reason, the results of this study should be used as a basic reference for improving the quality of service at the Malang UNISMA Hospital and as an initial lesson for further research.
Research of dynamics of monovalent ions in urine at various stages of urolithiasis development in in vivo experiment
Authors: Verlov N. A. , Gulina L. S. , Burdakov V. S. , Kulakov I. S. , Landa S. B. , Bogdanov A. A. , Yakovleva A. V. , Emanuel V. L. 
Published: March 2023

Introduction. Experimental model of intraperitoneal injection of sodium oxalate is one of the most promising and practical models of oxalate urolithiasis in rodents.Purpose of the study. To describe the urolithiasis progression in experimental animals with regard to the changes in the ion balance at various stages of pathology formation.Materials and methods. We treated male ICR (CD‑1) outbred laboratory mice with a single injection of sodium oxalate (NaOx) to perform nephrolithiasis modeling. The ionic composition of urine and blood serum in the control and experimental groups was examined by capillary electrophoresis. The presence of oxalate crystals in the urine sediment and histological data can assess the severity of the pathology.Results and conclusions. Increase of the level of Na and Ca ions and decrease of the level of K, NH4, Mg ions was observed in 4 hours and 24 hours after intraperitoneal injection of sodium oxalate, that can be regarded as a depression of tubular reabsorption and secretion.
Uncovering the significance of expanded CD8+ large granular lymphocytes in inclusion body myositis: Insights into T cell phenotype and functional alterations, and disease severity
Authors: McLeish Emily , Sooda Anuradha , Slater Nataliya , Kachigunda Barbara , Beer Kelly , Paramalingam Shereen , Lamont Phillipa J. , Chopra Abha , Mastaglia Frank Louis , Needham Merrilee , Coudert Jerome David 
Published: March 2023

IntroductionInclusion body myositis (IBM) is a progressive inflammatory myopathy characterised by skeletal muscle infiltration and myofibre invasion by CD8+ T lymphocytes. In some cases, IBM has been reported to be associated with a systemic lymphoproliferative disorder of CD8+ T cells exhibiting a highly differentiated effector phenotype known as T cell Large Granular Lymphocytic Leukemia (T-LGLL). MethodsWe investigated the incidence of a CD8+ T-LGL lymphoproliferative disorder in 85 IBM patients and an aged-matched group of 56 Healthy Controls (HC). Further, we analysed the phenotypical characteristics of the expanded T-LGLs and investigated whether their occurrence was associated with any particular HLA alleles or clinical characteristics. ResultsBlood cell analysis by flow cytometry revealed expansion of T-LGLs in 34 of the 85 (40%) IBM patients. The T cell immunophenotype of T-LGLHIGH patients was characterised by increased expression of surface molecules including CD57 and KLRG1, and to a lesser extent of CD94 and CD56 predominantly in CD8+ T cells, although we also observed modest changes in CD4+ T cells and γδ T cells. Analysis of Ki67 in CD57+ KLRG1+ T cells revealed that only a small proportion of these cells was proliferating. Comparative analysis of CD8+ and CD4+ T cells isolated from matched blood and muscle samples donated by three patients indicated a consistent pattern of more pronounced alterations in muscles, although not significant due to small sample size. In the T-LGLHIGH patient group, we found increased frequencies of perforin-producing CD8+ and CD4+ T cells that were moderately correlated to combined CD57 and KLRG1 expression. Investigation of the HLA haplotypes of 75 IBM patients identified that carriage of the HLA-C*14:02:01 allele was significantly higher in T-LGLHIGH compared to T-LGLLOW individuals. Expansion of T-LGL was not significantly associated with seropositivity patient status for anti-cytosolic 5'-nucleotidase 1A autoantibodies. Clinically, the age at disease onset and disease duration were similar in the T-LGLHIGH and T-LGLLOW patient groups. However, metadata analysis of functional alterations indicated that patients with expanded T-LGL more frequently relied on mobility aids than T-LGLLOW patients indicating greater disease severity. ConclusionAltogether, these results suggest that T-LGL expansion occurring in IBM patients is correlated with exacerbated immune dysregulation and increased disease burden.
An open-label observational study and meta-analysis of non-invasive vagus nerve stimulation in medically refractory chronic cluster headache
Authors: Simmonds Lucy , Lagrata Susie , Stubberud Anker , Cheema Sanjay , Tronvik Erling , Matharu Manjit , Kamourieh Salwa 
Published: March 2023

BackgroundMany patients with cluster headache (CH) are inadequately controlled by current treatment options. Non-invasive vagus nerve stimulation (nVNS) is reported to be effective in the management of CH though some studies suggest that it is ineffective.ObjectiveTo assess the safety and efficacy of nVNS in chronic cluster headache (CCH) patients.MethodWe prospectively analysed data from 40 patients with refractory CCH in this open-label, observational study. Patients were seen in tertiary headache clinics at the National Hospital for Neurology and Neurosurgery and trained to use nVNS as preventative therapy. Patients were reivewed at one month and then three-monthly from onset. The primary endpoint was number of patients achieving ≥50% reduction in attack frequency at 3  months. A meta-analysis of all published studies evaluating the efficacy of nVNS in CCH was also conducted. We searched MEDLINE and EMBASE for all studies investigating the use of nVNS as a preventive or adjunctive treatment for CCH with five or more participants. Combined mean difference and responder proportions with 95% confidence intervals (CI) were calculated from the included studies.Results17/40 patients (43%) achieved ≥50% reduction in attack frequency at 3  months. There was a significant reduction in monthly attack frequency from a baseline of 124 (±67) attacks to 79 (±63) attacks in month 3 (mean difference 44.7; 95% CI 25.1 to 64.3; p &lt; 0.001). In month 3, there was also a 1.2-point reduction in average severity from a baseline Verbal Rating Scale of 8/10 (95% CI 0.5 to 1.9; p = 0.001). Four studies, along with the present study, were deemed eligible for meta-analysis, which showed a responder proportion of 0.35 (95% CI 0.07 to 0.69, n = 137) and a mean reduction in headache frequency of 35.3 attacks per month (95% CI 11.0 to 59.6, n = 108), from a baseline of 105 (±22.7) attacks per month.ConclusionThis study highlights the potential benefit of nVNS in CCH, with significant reductions in headache frequency and severity. To better characterise the effect, randomised sham-controlled trials are needed to confirm the beneficial response of VNS reported in some, but not all, open-label studies.
Evaluating the effect of R-Baclofen and LP-211 on autistic behavior of the BTBR and Fmr1-KO mouse models
Authors: Sharghi Shirin , Flunkert Stefanie , Daurer Magdalena , Rabl Roland , Chagnaud Boris Philippe , Leopoldo Marcello , Lacivita Enza , Hutter-Paier Birgit , Prokesch Manuela 
Published: March 2023

IntroductionAutism spectrum disorder (ASD) is a persistent neurodevelopmental condition characterized by two core behavioral symptoms: impaired social communication and interaction, as well as stereotypic, repetitive behavior. No distinct cause of ASD is known so far; however, excitatory/inhibitory imbalance and a disturbed serotoninergic transmission have been identified as prominent candidates responsible for ASD etiology.MethodsThe GABAB receptor agonist R-Baclofen and the selective agonist for the 5HT7 serotonin receptor LP-211 have been reported to correct social deficits and repetitive behaviors in mouse models of ASD. To evaluate the efficacy of these compounds in more details, we treated BTBR T+ Itpr3tf/J and B6.129P2-Fmr1tm1Cgr/J mice acutely with R-Baclofen or LP-211 and evaluated the behavior of animals in a series of tests.ResultsBTBR mice showed motor deficits, elevated anxiety, and highly repetitive behavior of self-grooming. Fmr1-KO mice exhibited decreased anxiety and hyperactivity. Additionally, Fmr1-KO mice’s ultrasonic vocalizations were impaired suggesting a reduced social interest and communication of this strain. Acute LP-211 administration did not affect the behavioral abnormalities observed in BTBR mice but improved repetitive behavior in Fmr1-KO mice and showed a trend to change anxiety of this strain. Acute R-Baclofen treatment improved repetitive behavior only in Fmr1-KO mice.ConclusionOur results add value to the current available data on these mouse models and the respective compounds. Yet, additional studies are needed to further test R-Baclofen and LP-211 as potential treatments for ASD therapy.
Nutritional supplements improve cardiovascular risk factors in overweight and obese patients: A Bayesian network meta-analysis
Authors: Yu Zengli , Zhao Danyang , Liu Xinxin 
Published: March 2023

BackgroundOverweight and obesity are considered as one of the major risk factors for cardiovascular diseases (CVD). At present, many studies have proved that multiple nutritional supplements play an active role in metabolic diseases. However, the comparative efficacy of different nutritional supplements in improving indicators of cardiometabolic risk in obese and overweight patients is uncertain.MethodsCochrane Library, PubMed, Embase, and Web of Science were searched for the period from January 1990 to March 2022. A random-effect model was built in the Bayesian network meta-analysis. The surface under the cumulative ranking analysis (SUCRA) and clustering rank analysis was performed for ranking the effects.ResultsThe study included 65 RCTs with 4,241 patients. In terms of glucose control, probiotic was more conductive to improve FBG (MD: −0.90; 95%CrI: −1.41 to −0.38), FINS (MD: −2.05; 95%CrI: −4.27 to −0.02), HOMA-IR (MD: −2.59; 95%CI −3.42 to −1.76). Probiotic (MD: −11.15, 95%CrI −22.16 to −1.26), omega-3 (MD: −9.45; 95%CrI: −20.69 to −0.93), VD (MD: −17.86; 95%CrI: −35.53 to −0.27), and probiotic +omega-3 (MD: 5.24; 95%CrI: 0.78 to 9.63) were beneficial to the improvement of TGs, TC and HDL-C, respectively. The SUCRA revealed that probiotic might be the best intervention to reduce FBG, FINS, HOMA-IR; Simultaneously, α-lipoic acid, VD, and probiotic + omega-3 might be the best intervention to improve TGs, TC, and HDL-C, respectively. Cluster-rank results revealed probiotic had the best comprehensive improvement effect on glucose metabolism, and probiotic + omega-3 may have a better comprehensive improvement effect on lipid metabolism (cluster-rank value for FBG and FINS: 3290.50 and for TGs and HDL-C: 2117.61).ConclusionNutritional supplementation is effective on CVD risk factors in overweight and obese patients. Probiotic supplementation might be the best intervention for blood glucose control; VD, probiotic + omega-3 have a better impact on improving lipid metabolism. Further studies are required to verify the current findings.
Comprehensive analysis reveals CCDC60 as a potential biomarker correlated with prognosis and immune infiltration of head and neck squamous cell carcinoma
Authors: Liu Zhixin , Chen Shuai , Jia Wenming , Qian Ye , Yang Xiaoqi , Zhang Minfa , Fang Tianhe , Liu Heng 
Published: March 2023

BackgroundCoiled-coil domain containing 60 (CCDC60) is a member of the CCDC family, which participates in the progression of many types of cancer. However, the prognostic value of CCDC60 in head and neck squamous cell carcinoma (HNSC) and its function in tumor immunity remain unclear.MethodsCCDC60 expression and its prognostic potential in HNSC were evaluated by bioinformatics approaches, which was validated in human HNSC samples. Genetic alteration analysis of CCDC60 and the underlying biological function of CCDC60 related co-expressed genes in HNSC were analyzed. The impact of CCDC60 on the regulation of immune infiltration in HNSC was comprehensively investigated. In vitro, a series of functional assays on CCDC60 were performed in HNSC cells.ResultsOur study has indicated that compared with the adjacent normal tissues, CCDC60 expression was considerably downregulated in HNSC tissues. High CCDC60 expression was connected with favorable outcome of HNSC patients, and its prognostic significance was examined by distinct clinical characteristics. We identified the CCDC60-related co-expression genes, which were mainly enriched in the NOD-like receptor signaling pathway associated with the inhibition of tumor growth, leading to a better prognosis of HNSC patients. In vitro, CCDC60 overexpression significantly inhibited the growth, migration and invasiveness but regulated cell cycle progression, and promoted cell adhesion of Fadu and Cal27 cells. Additionally, high CCDC60 expression had strong connections with the infiltrating levels of immune cells, immune marker sets, immunomodulators and chemokines in HNSC, suggesting that targeting CCDC60 could be a promising strategy to enhance the efficacy of immunotherapy for HNSC patients.ConclusionTumor suppressor CCDC60 may be identified as a prognostic and immune-related indicator in HNSC, which had the potential functions in regulating the immune infiltration of HNSC and improving the response to immunotherapy for HNSC patients.
Prognostic and clinicopathological role of geriatric nutritional risk index in patients with diffuse large B-cell lymphoma: A meta-analysis
Authors: Cao Dan , Zhang Zongxin 
Published: March 2023

BackgroundPrevious studies have explored the relationship between the geriatric nutritional risk index (GNRI) and survival outcomes of diffuse large B-cell lymphoma (DLBCL) cases, but the results were inconsistent. Consequently, the present meta-analysis was conducted to investigate how GNRI affects DLBCL and its function in terms of prognosis.MethodsThe Web of Science, PubMed, Embase, and Cochrane Library databases were thoroughly searched until January 18, 2023. We calculated combined hazard ratios (HRs) and 95% confidence intervals (CIs) to estimate the relationship between the GNRI and survival outcomes of patients with DLBCL.ResultsThis meta-analysis included seven articles involving 2,353 cases. A lower level of GNRI predicted dismal overall survival (HR=1.40, 95% CI=1.25–1.56, p&lt;0.001) and inferior progression-free survival (HR=1.46, 95% CI=1.19-1.80, p&lt;0.001) of DLBCL patients. Moreover, a low GNRI was significantly related to Eastern Cooperative Oncology Group Performance Status ≥2 (odds ratio [OR]=4.55, 95% CI=2.75–7.54, p&lt;0.001), Ann Arbor stage III–IV (OR=2.91, 95% CI=2.38–3.57, p&lt;0.001), B symptoms (OR=3.51, 95% CI=2.34–5.29, p&lt;0.001), and extranodal disease (OR=2.90, 95% CI=2.32–3.63, p&lt;0.001).ConclusionA lower GNRI level predicted poorer short- and long-term prognosis in patients with DLBCL. A low GNRI was correlated with clinical factors of disease progression in DLBCL patients.
Helsmoortel–van der Aa syndrome in a Chinese pediatric patient due to ADNP nonsense mutation: A case report
Authors: Chen Li-juan , You Zhong-min , Chen Wen-hong , Yang Si , Feng Chun-chen , Wang Hai-yong , Wang Ting , Zhu Yuan-yuan 
Published: March 2023

BackgroundHelsmoortel–van der Aa syndrome, also known as ADNP syndrome, is a condition that causes developmental delay, language impairment, autism spectrum, and variable extraneurologic features. It is caused by heterozygous mutations in the ADNP gene on chromosome 20q13. Most of the genetic causes of Helsmoortel–van der Aa syndrome have been reported are as de novo nonsense or frameshift stop mutations in exon 5 of ADNP gene, while fewer truncating variants were discovered in exons 4 and the 5′ end of exon 5.MethodsIn our study, a 4-year-old female Chinese patient was reported with delayed psychomotor development, language impairment, ataxia, anxiety, aggressive behavior, and congenital heart defect. Trio whole exome sequencing and copy number variation sequencing were performed.ResultsA novel de novo heterozygous pathogenic mutation c.568C &gt; T (p.Gln190Ter) was identified in the ADNP gene of the proband. His unaffected parents did not have the variant. According to the American College of Medical Genetics (ACMG) guidelines, c.568C &gt; T was classiﬁed as “pathogenic”.ConclusionOur report indicated that c.568C &gt; T (p.Gln190Ter) in ADNP gene is the cause of abnormal development of the nervous system, congenital heart disease and strabismus, broadening the spectrum of ADNP gene mutations associated with Helsmoortel–van der Aa syndrome.