bluuebunny/crossref_metadata_2025_split huggingface dataset:
On the Composition of LiNi0.5Mn1.5O4 Cathode Active Materials
Authors: Stüble Pirmin , Mereacre Valeriu , Geßwein Holger , Binder Joachim R. 
Published: January 2023

AbstractLiNi0.5Mn1.5O4 (LNMO) cathode active materials for lithium‐ion batteries have been investigated for over 20 years. Despite all this effort, it has not been possible to transfer their favorable properties into applicable, stable battery cells. To make further progress, the research perspective on these spinel type materials needs to be updated and a number of persisting misconceptions on LNMO have to be overcome. Therefore, the current knowledge on LNMO is summarized and controversial points are addressed by detailed considerations on the composition and crystallography of LNMO. The findings are supported by an in‐situ high temperature X‐ray diffraction study and the investigation of four different types of LNMO materials, including Mn(III) rich ordered LNMO, and disordered LNMO with low Mn(III) content. It is shown that the importance of cation order is limited to a small composition range. Furthermore, new evidence contradicting the idea of oxygen defects in LNMO is presented and an enhanced classification of LNMO based on the Ni content of the spinel phase is proposed. Moreover, a balanced chemical equation for the formation of LNMO is presented, allowing for comprehensive calculations of key properties of LNMO materials. Finally, suitable target compositions and calcination programs are suggested to obtain better LNMO materials.
Discovery of Norbornene as a Novel Hydrophobic Tag Applied in Protein Degradation
Authors: Xie Shaowen , Zhan Feiyan , Zhu Jingjie , Sun Yuan , Zhu Huajian , Liu Jie , Chen Jian , Zhu Zheying , Yang Dong‐Hua , Chen Zhe‐Sheng , Yao Hong , Xu Jinyi , Xu Shengtao 
Published: January 2023

AbstractHydrophobic tagging (HyT) is a potential therapeutic strategy for targeted protein degradation (TPD). Norbornene was discovered as an unprecedented hydrophobic tag in this study and was used to degrade the anaplastic lymphoma kinase (ALK) fusion protein by linking it to ALK inhibitors. The most promising degrader, Hyt‐9, potently reduced ALK levels through Hsp70 and the ubiquitin−proteasome system (UPS) in vitro without compensatory upregulation of ALK. Furthermore, Hyt‐9 exhibited a significant tumor‐inhibiting effect in vivo with moderate oral bioavailability. More importantly, norbornene can also be used to degrade the intractable enhancer of zeste homolog 2 (EZH2) when tagged with the EZH2 inhibitor tazemetostat. Thus, the discovery of novel hydrophobic norbornene tags shows promise for the future development of TPD technology.
Somalactams A–D: Anti‐inflammatory Macrolide Lactams with Unique Ring Systems from an Arctic Actinomycete Strain
Authors: Yang Fan , Sang Moli , Lu Jing‐Rong , Zhao Hui‐Min , Zou Yike , Wu Wei , Yu Yong , Liu Ya‐Wei , Ma Wencheng , Zhang Yun , Zhang Wei , Lin Hou‐Wen 
Published: January 2023

AbstractFour new PKS‐NRPS‐derived macrolide lactams with three unique ring fusion types were discovered from the Arctic sponge associated actinomyceteStreptomyces somaliensis1107 using a genome mining strategy. Their structures were elucidated by a combination of MS, NMR spectroscopic analysis, and single‐crystal X‐ray diffraction. Biosynthetically, a novel gene clustersmlconsisting of three polyketide synthases and one hybrid polyketide synthase‐nonribosomal peptide synthetase together with cytochrome P450s and flavin‐containing monooxygenases and oxidoreductases was demonstrated to assemble the unique skeleton. Pharmacological studies revealed that compound1displayed a potent anti‐inflammatory effect without cytotoxicity. It inhibited IL‐6 and TNF‐α release in the serum of LPS‐stimulated RAW264.7 macrophage cells with IC50values of 5.76 and 0.18 μM, respectively, and modulated the MAPK pathway. Moreover, compound1alleviated LPS‐induced systemic inflammation in our transgenic fluorescent zebrafish model.
One‐Handed Helical Tubular Ladder Polymers for Chromatographic Enantioseparation**
Authors: Zheng Wei , Oki Kosuke , Saha Ranajit , Hijikata Yuh , Yashima Eiji , Ikai Tomoyuki 
Published: January 2023

AbstractDefect‐free one‐handed contracted helical tubular ladder polymers with a π‐electron‐rich cylindrical helical cavity were synthesized by alkyne benzannulations of the random‐coil precursor polymers containing 6,6′‐linked‐1,1′‐spirobiindane‐7,7′‐diol‐based chiral monomer units. The resulting tightly‐twisted helical tubular ladder polymers showed remarkably high enantioseparation abilities toward a variety of chiral hydrophobic aromatics with point, axial, and planar chiralities. The random‐coil precursor polymer and analogous rigid‐rod extended helical ribbon‐like ladder polymer with no internal helical cavity exhibited no resolution abilities. The molecular dynamics simulations suggested that the π‐electron‐rich cylindrical helical cavity formed in the tightly‐twisted tubular helical ladder structures is of key importance for producing the highly‐enantioseparation ability, by which chiral aromatics can be enantioselectively encapsulated by specific π‐π and/or hydrophobic interactions.
Time delay margin for islanded microgrid with parameter uncertainty using fractional order proportional‐integral‐derivative controller
Authors: Hamidi Beheshti Mohammad Taghi , Khosravi Shabnam 
Published: January 2023

AbstractIn this article, an islanded microgrid (MG) consisting of the diesel generator (DEG), the photovoltaic panel (PV), the wind turbine generator (WTG), the battery energy storage system (BESS), and the control unit is considered. In the islanded MGs, the control signals are exchanged on the open communication network, which results in the time delays in the input and the output of the islanded MG central controller (MGCC). The time delay has a destructive effect on the islanded MG stability. Thus, finding the maximum allowable time delay bound (MADB) is a significant issue. Since it is shown that the fractional order systems have larger stability region and more robustness rather than the corresponding integer order systems, in this research, we propose the fractional order proportional‐integral‐derivative (FOPID) controller as the MGCC to achieve a larger MADB value. As another innovation, in this article, a method is presented in which the MADB of the islanded MG system is determined considering the parametric uncertainties related to the damping coefficient (D) and the inertia constant (H). It is shown that the percentage improvement in the MADB of the uncertain MG system with the designed FOPID controller over the integer order proportional‐integral‐derivative (IOPID) controller is 9.64%. The accuracy of the proposed method is verified by simulation results in Matlab.
Gravitational waves or x‐ray counterpart? No need to choose
Authors: Mignon‐Risse Raphaël , Varniere Peggy , Casse Fabien 
Published: January 2023

AbstractBinary black holes emit gravitational waves (GWs) as they inspiral toward coalescence. Searches for electromagnetic counterparts to these GWs rely on looking for common sources producing both signals. In this article, we take a different approach: we investigate the impact of radiation zone effects, including retardation effects and gravitational wave propagation onto the circumbinary disk around stellar‐mass, spinning black holes, using general relativistic hydrodynamical simulations. Then we used a general relativistic ray‐tracing code to extract its x‐ray spectrum and lightcurve. This allowed us to show that radiation zone effects leave an imprint onto the disk, leading to quasi‐periodic patterns in the x‐ray lightcurve. The amplitude of the modulation is weak () but increases with time and is strongly dependent on the inclination angle.
Neutron star versus neutral star: On the 90th anniversary of Landau's publication in astrophysics
Authors: Xu Renxin 
Published: January 2023

AbstractIn the late age of developing quantum mechanics, Lev Landau made great efforts to understand the nature of matter, even stellar matter, by applying the quantum theory. Ninety years ago, he published his idea of “neutron” star, which burst upon him during his visit over Europe in the previous year. The key point that motivated Landau to write the paper is to make a state with lower energy for “gigantic nucleus”, avoiding extremely high kinematic energy of electron due to the new Fermi–Dirac statistics at that time. Landau had no alternative but to neutralize by “combining a proton and an electron” before the discovery of neutron. However, our understanding of the nature has fundamentally improved today, and another way (strangeonization) could also embody neutralization and thus a low‐energy state that Landau had in mind, which could further make unprecedented opportunities in this multi‐messenger era of astronomy. Strangeon matter in “old” physics may impact dramatically today's physics, from compact stars initiated by Landau, to cosmic rays and dark matter. In this essay, we are making briefly the origin and development of neutron star concept to reform radically, to remember Landau's substantial contribution to astrophysics and to recall those peculiar memories.
Synthesis, Electrochemistry, and Thermal Stability of High‐Energy Ball‐Milled Silicon‐based Alloy Anodes in Lithium‐Ion Batteries**
Authors: Zhang Xingyu , Wang Luqi , Zheng Tianye , Lam Kwok‐ho 
Published: January 2023

AbstractThe fast capacity degradation of silicon‐based anodes significantly limits the application in lithium‐ion battery (LIB) industries. Recently, Si−CuO composites have been reported as promising anodes in terms of being cost‐effective and technically feasible, but improved cycle stability is still desired. This work introduces a proper amount of NiO into the Si−CuO composites via a facile high‐energy ball‐milling method. The study reveals that compared to the binary Si‐CuO composites, Si−CuO−NiO samples have less pronounced volume change during the cycles due to the formation of rich‐Si NiSi2. More specifically, Si87.5(CuO)3.4(NiO)9.1 shows the highest 100‐cycle capacity retention of ∼86.9 % at 0.2 C with an average coulombic efficiency of ∼99.4 %. Moreover, the thermal stability investigation demonstrates that the temperature of 600 °C is suitable to coat a carbon layer on Si87.5(CuO)3.4(NiO)9.1, where the microstructure and the uniform element distribution produced in the milling process as well as the suppression to the cr‐Li3.75Si formation can be maintained to the maximum extent, thus with further enhanced electrochemical performance.
Do fine needle aspirate cytomorphological features correlate with positron emission tomography findings of metastatic non‐small cell lung carcinoma in lymph nodes?
Authors: Keyhanian Kianoosh , Sekhon Harmanjatinder S. 
Published: January 2023

AbstractBackgroundOur objective was to correlate cytomorphological features of metastatic non‐small cell lung carcinoma (mNSCLC) with maximal standardized uptake value (mSUV) of positron emission tomography (PET) in Lymph nodes (LNs).MethodsPositive cytology slides of 114 LNs were reviewed from 100 patients with mNSCLC who had undergone PET study. Student's t‐test was used for statistical comparisons.ResultsMean patients' age: 68.5, 54% male. LNs locations were: mediastinum: 99, lung hilum: 13, peribronchial: 1, axilla: 1. Final diagnoses were: Adenocarcinoma: 86, squamous cell carcinoma: 28 LNs. Within the adenocarcinoma subgroup, histological patterns correlate with mSUV. Acinar and papillary patterns were associated with significantly lower mSUVs (mean ± standard error (SE): 7.9 ± 0.9 and 9.2 ± 0.8, respectively) than solid pattern (13.0 ± 1.2; p values: 0.001 and 0.009, respectively). Similar difference exists between patterns associated with low‐ and high‐grade adenocarcinoma (Mean ± SE: 9.2 ± 0.8 and 12.0 ± 1.0, respectively. p value: 0.02). Interestingly, micropapillary pattern was associated with the lowest mSUV amongst all patterns (Mean ± SE: 5.4 ± 1.1). Other features that correlated with higher mSUV were necrosis, moderate/severe nuclear atypia, lower lymphoid tissue yield, and contralateral LN involvement.ConclusionsIn LNs with mNSCLC, certain cytomorphological features are associated with higher mSUV. Micropapillary, a pattern considered as high‐grade, is associated with lower SUV values; hence, a lower SUV threshold may raise concern for metastasis. Although high SUV is associated with LN metastasis, lower SUV levels in certain adenocarcinomas suggest correlation with clinical and morphological characteristics could be valuable in tailoring therapeutic management.
Radiation‐induced myofibroblastoma within the nasal sinus requiring maxillectomy and ethmoidectomy: A case report and literature review
Authors: Meyer David B. , Larkins Michael C. , Klose Charles , Maher Mohammed , Zeches Breann A. , Brodish Brian N. , Ju Andrew W. , Prenshaw Karyn 
Published: January 2023

AbstractWe report a case of radiation‐induced myofibroblastoma of the right nasal cavity in a patient with a remote history of radiotherapy for pediatric retinoblastoma. The patient required maxillectomy and ethmoidectomy. To our knowledge, a rare number of cases have been reported in this location.
A rare case of pancytopenia causing‐ Sheehan's syndrome: Case report and literature review
Authors: Gao Xiao‐Han , Wang Yuan , Wang Rui‐Cang , ‐Yuan Jun , Yang Jie , Zhang Xiao‐Xia , Li Jie 
Published: January 2023

AbstractWe describe the case of a 58‐year‐old woman who was presented with pancytopenia and hypofibrinogenemia. Treatment with iron supplementation was not satisfactory. Physical findings and a history of a massive postpartum hemorrhage suggested Sheehan's syndrome(SS). After thyroxine and glucocorticoid replacement therapy, the blood cell count improved. SS is a rare etiology of hemocytopenia, of which hematologists need to be aware. We conclude that hormonal therapy can produce full hematological recovery.
Surgical endodontic treatment of maxillary incisors: Case report
Authors: Almansour Moazzy I. 
Published: January 2023

AbstractThis study aims to highlight the possibility of an effective endodontic surgical surgery when nonsurgical treatment of the right maxillary anterior teeth has failed. One year after the apicoectomy, the periapical lesion has completely healed, new bone has formed, and the patient is symptom‐free.
Congenital chikungunya in a neonate with early‐onset sepsis and petechiae: An unusual case report
Authors: Bin Sakviseth , Phou Kimyi , Im Sethikar 
Published: January 2023

AbstractChikungunya, a mosquito‐borne disease, is posing threat to neonatal population in Cambodia because of its challenging diagnosis and insufficient attention compared with Dengue. In what follows, we present a case of serologically‐confirmed congenital chikungunya in a newborn presenting early‐onset sepsis, and the mother was underdiagnosed with intrapartum flu‐like infection.
Spontaneous intracranial hypotension complicated by unilateral subdural hematoma, coma, and the rare Kernohan's notch phenomenon
Authors: Ozyigit Ahmet 
Published: January 2023

AbstractSpontaneous intracranial hypotension (SIH) is a highly underdiagnosed condition with a wide range of manifestations. Although SIH has traditionally been viewed as having a benign disease course, recent evidence suggests otherwise. In this case report, we present a 71‐year‐old woman who was previously treated with a tapered dose of corticosteroids for an episode of SIH with behavioral manifestations. In this current report, we present her second episode which was complicated by a unilateral sub‐acute subdural hematoma leading to loss of consciousness and coma. While the patient regained full consciousness and recovered considerably, she still suffers from ipsilateral hemiparesis as a result of Kernohan's notch phenomenon 2 years post‐hospitalization. To the author's knowledge, this is the first case to involve persistent motor deficit after the resolution of SIH. We believe that surgical hematoma evacuation prior to addressing the cerebrospinal fluid leak may have contributed to aggregated downward displacement of the brain precipitating Kernohan's notch phenomenon.
General Concepts and Recent Advances in the Electrochemical Transformation of Chloro‐ and Hydrosilanes
Authors: Beck Alexander D. , Haufe Stefan , Waldvogel Siegfried R. 
Published: January 2023

AbstractOrganosilanes play an important role in organic synthesis as well as in a variety of further areas, ranging from life science to transportation. Especially, the electrochemical access has become increasingly important in the past years and developed into an essential topic due to new conceptual approaches and mediated reaction control. With the commercial availability of high‐quality electrochemical equipment, the technical requirements for electro‐conversion are at hand to a wide audience. This results in the need for a concise survey of electrochemical silane transformation, appropriate for novices as well as experts alike. This review provides an overview of the most relevant work in this field, identifies common obstacles in working with chlorosilanes and hydrosilanes and bridges the gap between known techniques and novel methods with respect to their electrochemical conversion. The historical development is outlined with reference to the various cathodic as well as anodic conversions and should encourage to expand the research field of electrochemical silane transformation.
Bacterial epiglottitis superimposed on oropharyngeal cancer: A case report
Authors: Larkins Michael C. , Meyer David B. , Lowery Kenneth , Speicher Rachel L. , Brodish Brian N. , Ju Andrew W. 
Published: January 2023

AbstractBackgroundPatients undergoing chemotherapy and radiotherapy are placed in an immunocompromised state worth consideration in the event of potential airway compromise, especially when superimposed on an airway‐obstructing tumor. We report a case of bacterial epiglottitis in a patient with active oropharyngeal cancer (OPC), who presented in such a way that an infectious etiology was not initially considered in the patient's care. To our knowledge, such a circumstance has not been reported in the literature.CaseHere, we report a case of a 68‐year‐old male with advanced‐stage OPC who developed respiratory distress and underwent emergent tracheostomy. The patient was diagnosed postoperatively with Haemophilus influenza and Pseudomonas aerugeniosa. Following antibiotic treatment, the patient recovered to the point in which he could then undergo concomitant chemoradiation. The patient later had a recurrence of P. aerugeniosa during their radiotherapy that was also treated with antibiotics. The patient experienced continued symptoms related to their OPC and underwent pharyngectomy. Despite the initial success of this procedure, the patient experienced tumor recurrence and succumbed to his disease.ConclusionThis case underscores the importance of considering multiple etiologies concerning airway compromise, as the consequence of delayed cancer treatment may be loss of local cancer control.
Role of barley stem reserves in the maintenance of grain yield under terminal drought
Authors: Tafresh Razieh Sarabadani , Shobbar Zahra‐Sadat , Shahbazi Maryam , Bihamta Mohammadreza , Karami Amin , Moradi Mohammad , Nikkhah Hamidreza 
Published: January 2023

AbstractUnder terminal drought conditions, due to the limitation of current photosynthesis, the impact of cereal stem carbohydrates reserves and their contribution to the grain yield preservation could be enhanced. The role of stem fructan remobilization on yield of barley was examined under drought conditions in the present study. The fructan accumulation and remobilization rate of the penultimate internode were studied in Morocco 9–75 and Yousef, as drought susceptible and tolerant barley (Hordeum vulgare L.) cultivars, respectively. Drought stress increased the fructan accumulation and remobilization in Yousef, supporting it from severe yield loss compared to Morocco cultivar. Under drought stress conditions, during grain filling of Yousef cultivar, the strong correlations were observed between the relative expression of the key genes involved in the fructan metabolism, that is 1‐SST and 6‐SFT (fructan biosynthesis genes) with the fructan content, as well as between the expression of 1‐FEH (fructan exohydrolase) and SUT1 (sucrose transporter) with fructan remobilization. Yousef cultivar contained considerable water‐soluble carbohydrate content of stem internodes, and a rise in osmolytes such as fructan may lead to the efficient osmotic adjustment, which in turn resulted in the maintenance of the water content and stomatal conductance. Based on the results, enhanced fructan accumulation and its induced remobilization under drought conditions can play an important role in yield stability of Yousef under stress. The barley genotypes with high potential for fructan production and remobilization under terminal drought stress could provide the appropriate materials for drought tolerance breeding and screening for these traits.
Two for the price of one: eDNA metabarcoding reveals temporal and spatial variability of mussel and fish co‐distributions in Michigan riverine systems
Authors: Dokai William K. , Barry Patrick D. , Zanatta Dave T. , Gruenthal Kristen M. , McPhee Megan V. , McIntyre Peter B. , Larson Wesley A. 
Published: January 2023

AbstractFreshwater mussels (family Unionidae) are among the world's most endangered taxa, with almost 75% of North American taxa classified as a species of concern, threatened, or endangered. Despite the critical importance of comprehensive distributional data for the conservation of unionids and fishes, these data are often lacking because of the labor and resources associated with traditional survey methods. During their larval stage, unionid mussels use various fish species as obligate hosts, making native fish species vital to unionid persistence and an understanding of host distribution similarly important. Here, we utilized an eDNA metabarcoding approach to evaluate patterns of co‐distribution of unionid mussels and fishes along ~362 km of the densely sampled Grand River network as well as the outlets of 19 tributaries along the eastern shore of Lake Michigan, USA. We detected a total of 21 mussel and 40 fish taxa, with distinctive composition of both mussel and fish assemblages across tributaries and differences in fish taxa between sampling periods. Notably, we detected more mussel taxa within the Grand River watershed than at the outlets of all 20 rivers combined. Within the Grand River network, two fish taxa (Pylodictus olivaris and Cyprinella) were found more frequently in areas of high mussel diversity, and three fish taxa more frequently in areas of low mussel diversity (Umbra, Leuciscidae, and Etheostoma). There was little difference between eDNA detections of mussels from samples collected in June versus August, but we detected significantly more fish taxa in August compared to June. Taken together, our findings demonstrate the value of eDNA metabarcoding for evaluating co‐distribution of ecologically connected taxa. The use of eDNA as a tool for determining distributions of mussels and their obligate hosts may facilitate conservation efforts for these imperiled taxa.