bluuebunny/crossref_metadata_2025_split huggingface dataset:
Distribution and habitat assessment of an Endangered hummingbird: the Grey-bellied Comet Taphrolesbia griseiventris
Authors: Cuadros Sandra , Angulo Fernando 
Published: March 2023

Summary
The Grey-bellied Comet (Taphrolesbia griseiventris) is a hummingbird species endemic to northern Peru and listed as Endangered by IUCN due to its small and fragmented population. Despite this, little has been attempted to increase knowledge of its natural history and ecology to provide current information and better evaluate its conservation status. Here, we used known curated records of the species from the literature to generate a model of its potential distribution using MaxEnt, and we then validated the model in the field through direct observation in selected areas. Where the species was confirmed, we conducted a habitat characterisation with field data, and a threat assessment of the landscape using secondary data in ArcGIS. We found five new records of the species in the department of La Libertad at two different sites, confirming a new population. The habitat mostly comprised Andean scrub (17.6%) throughout its distribution, and the main threat in the habitat was human-induced fires for agricultural purposes and as a means of waste disposal. Our findings revealed new information on the distribution of the species with a potential habitat occupancy of 4–6% within its range. Furthermore, areas that were previously reported to harbour a population of the species no longer showed records despite intensive searches in the field. Finally, we discuss the implications for its conservation. Our results indicated that conservation measures to protect the Grey-bellied Comet are urgently needed, especially the declaration of a reserve in La Libertad, which might be the only area where the species is reliably present with good quality habitat.
Creating, Implementing, and Experiencing Research Opportunities: A Focus on Diversity, Equity, and Inclusion
Authors: Duncan Natasha T. , Balcazar Pablo , Gonzalez Daniella , Tamene Meron , Clawson Rosalee A. 
Published: March 2023

ABSTRACTHigh-impact educational practices benefit undergraduate students in a variety of ways. These opportunities include student–faculty research, study-abroad and study-away programs, and internships, among others. This study focuses on one type of these high-impact practices: research. Research experiences foster student engagement and success, and they especially matter for marginalized and minoritized students, who all too often are underrepresented in these experiences. This article discusses creating, implementing, and experiencing equity-minded research opportunities for students from three perspectives: department head, faculty mentor, and undergraduate participants.
Signs of prehistory. A Peircian semiotic approach to lithics
Authors: Guibert Justin , Pérez-Balarezo Antonio , Forestier Hubert 
Published: March 2023

AbstractHow can we understand prehistoric lithic objects? What meaning should we give them and what view should we adopt to claim access to their significance? How can we reduce and clarify our biases? This article is a proposal to introduce Peircian semiotics to review lithic objects. For a long time, these were apprehended as types, sometimes within evolutionary lineages; however, in this research, knapped stone objects will be perceived through a semio-pragmatic grid and reviewed as signs. The proposed approach is a new way of accessing the fields of technical phenomena of prehistoric communities. This new perception aims at a quest for objectivity, by clarifying the affective, analytical and interpretative a priori as an answer to the sometimes very personal view of the prehistorian on lithic objects. Charles Sanders Peirce’s logical theory of signs or semiotics is contextualized within an ‘artisanal’ reading of prehistoric tools as initiated by Éric Boëda and further developed by Michel Lepot. Through this phaneroscopic/phenomenological vision, the technical object, now a sign-object, is placed in action (semiosis) within a system of signs. This new trajectory is positioned both as a methodological tool and as an innovative milestone in the construction of a more logical episteme in Prehistory, taking lithics both as signs of past human activity and of archaeological representations.
A Monte Carlo study of the dose enhancement effects of high-z foils in proton therapy
Authors: Duke Kristen , Ahmad Salahuddin , Lau Andy 
Published: March 2023

AbstractBackground:This investigation quantifies the dose enhancement effect and dose distribution modifications due to the presence of high-z nanospheres in a proton beam.Methods:Various proton pencil beams of therapeutic energies (60–226 MeV) and spatial distribution of 2·7 mm spot size diameter were simulated onto a water phantom utilising the TOPAS Monte Carlo toolkit version 3.6.1. The simulation modelled either water or nanospheres of high-z materials (gold, silver or platinum) at the location of the Bragg Peak (BP) to compare the differences of the resulting dose distributions.Results:The introduction of the nanospheres increases the maximum dose, narrows the BP and shifts the BP location upstream compared to the water phantom with no nanospheres.Conclusions:This work shows that the local dose can be enhanced with the use of high-z nanoparticles in proton therapy, thereby increasing patient safety and decreasing side effects with the same amount of delivered radiation.
Giuseppe Verdi's Jérusalem between Adaptation and Self-Borrowing
Authors: Izzo Francesco 
Published: March 2023

Giuseppe Verdi's first French opera, Jérusalem (1847), has often been described as a French version of his fourth opera, I lombardi alla prima crociata (1843). It is hardly a straightforward translation, however; the process of adapting the source to the French stage involved substantial rewriting of the libretto, thoroughly recasting the storyline and therefore requiring numerous changes in the music. Thus, Verdi not only provided several entirely new sections for the score of Jérusalem, but also reused material from I lombardi in radically different dramatic settings.
The purpose of this article is to review changing attitudes toward Jérusalem through the twentieth century, and to assert that it may be perceived both as a reworking of the earlier opera and as a new work in which Verdi, under unique circumstances, deployed strategies of self-borrowing. The first part addresses the historiography of Jérusalem, tracing changing attitudes of commentators gradually recognizing the importance and worth of the French work, and the second part examines in detail the transfer of selected passages that Verdi borrowed from I lombardi and adapted to vastly changed contexts.
Delayed cover-crop termination and reduced herbicide inputs produce trade-offs in soybean phase of US Northeast forage-grain rotation
Authors: Ficks Teala S. , Karsten Heather D. , Wallace John M. 
Published: March 2023

AbstractRegion- and system-specific research is needed to understand the viability of delayed cover-crop termination (i.e., planting green) as an integrated weed management (IWM) tactic in no-till soybean. In a 3-yr field experiment, we evaluated the potential for planting green to facilitate elimination of soil-applied, preemergence residual herbicides within a soybean phase of a 6-yr grain–forage cropping systems experiment in Pennsylvania. This IWM tactic was contrasted with a Standard treatment, which included 14 to 21 d pre-plant termination of cereal rye and a two-pass herbicide program with preemergence herbicides. A 63% increase in cereal rye biomass production was observed within the IWM treatment in 2019, but only a 22% and 33% increase in 2020 and 2021, respectively. In 2020, significantly lower volumetric water content (%VWC) was observed within the IWM treatment in dates closest to planting and greater %VWC at multiple dates in June and July compared to the Standard treatment. No differences occurred in soybean populations, but soybean biomass at the V4 growth stage was reduced in the Standard treatment compared to the IWM treatment, which we attribute to injury from preemergence applications. The Standard treatment resulted in greater soybean yield (2,590 kg ha–1) than the IWM treatment (1,870 kg ha–1) in 2020, but yields were similar in other years. The IWM treatment resulted in 58% fewer herbicide inputs, as measured by the number of active ingredients applied, compared to the Standard over the 3-yr study. Yet, peak weed biomass did not differ between treatments. However, the IWM treatment resulted in greater total horseweed density and the number of horseweed plants that exceeded recommended size-based height thresholds (10 cm) compared to the Standard treatment just prior to postemergence applications (35–42 d after planting) in 2020 and 2021, underscoring the importance of integrating surface mulch residues with effective herbicide sites of action.
On the Seed Population of Solar Energetic Particles in the Inner Heliosphere
Authors: Wijsen N. , Li G. , Ding Z. , Lario D. , Poedts S. , Filwett R. J. , Allen R. C. , Dayeh M. A. 
Published: March 2023

AbstractParticles measured in large gradual solar energetic particle events are believed to be predominantly accelerated at shocks driven by coronal mass ejections (CMEs). Ion charge state and composition analyses suggest that the origin of the seed particle population for the mechanisms of particle acceleration at CME‐driven shocks is not the bulk solar wind thermal material, but rather a suprathermal population present in the solar wind. This suprathermal population could result from remnant material accelerated in prior solar flares and/or preceding CME‐driven shocks. In this work, we examine the distribution of this suprathermal particle population in the inner heliosphere by combining a magnetohydrodynamic simulation of the solar wind and a Monte Carlo simulation of particle acceleration and transport. Assuming that the seed particles are uniformly distributed near the Sun by solar flares of various magnitudes, we study the longitudinal distribution of the seed population at multiple heliocentric distances. We consider a nonuniform background solar wind, consisting of fast and slow streams that lead to compression and rarefaction regions within the solar wind. Our simulations show that the seed population at a particular location (e.g., 1 au) is strongly modulated by the underlying solar wind configuration. Corotating interaction regions and merged interactions regions can strongly alter the energy spectra of the seed particle populations. In addition, cross‐field diffusion plays an important role in mitigating strong variations of the seed population in both space and energy.
Pressure Solution Grain Boundary Sliding as a Large Strain Mechanism of Superplastic Flow in the Upper Crust
Authors: Gratier Jean‐Pierre , Menegon Luca , Renard François 
Published: March 2023

AbstractA mechanism accommodating large strain in superplastic flow with elongation of 100%–300%, is described for fine‐grained calcareous shales deformed at temperature of 200–335°C and depths of 5–8 km up to slate schists in the Oisans massif, Western Alps, France. Using electron microscopy techniques on thin sections parallel to the principal finite strain axes, we show that the shape ratios of the slightly elongated grains (1.4–1.6), mainly calcite and quartz, do not match the finite strains recorded by the markers of the deformation (truncated belemnites, folded veins) in the maximum elongation and shortening plane (ratio 6.7) or in the maximum and minimum elongations plane (ratio 2.4). Consequently, a grain boundary sliding mechanism is required to explain the measured large finite strains. The most soluble minerals (quartz, calcite, dolomite, and albite), which represent about 95% of the rock, accommodate deformation by pressure solution grain boundary sliding whereas the least soluble minerals (muscovite, chlorite, Fe‐Ti oxides) act as indenters or are passively reoriented. Pressure solution is especially efficient in polymineralic rocks. Soluble minerals, which have been healed together in veins or fossils, are much more resistant to deformation and act as rigid objects. Models with idealized tessellation of hexagonal grains and creep laws derived from pressure solution indentation experiments provide deformation maps. We discuss the main parameters of this ductile deformation in the upper crust (thermodynamic conditions, strain rate, stress, distance of mass transfer) and show possible drastic decrease of mass transfer efficiency with decrease of stress and strain rate.
Design and experimental study on pruning machine of Yunnan edible rose
Authors: Zhu Huibin , Zhang Xu , Qian Cheng , An Ran , Zhao Haoran , Ma Shiao , Bai Lizhen 
Published: March 2023

AbstractEdible rose is one of the main cash crops in Yunnan, China. Due to the high degree of lignification of rose stalks which is difficult to cut, and roses can only be pruned by hand after picking. Most of Yunnan Province is hilly landscape. Therefore, it is necessary to design an efficient small rose pruner for hills. Based on the experimental results of the physical and mechanical properties of rose stems, a simulation experiment of three different cutting methods was conducted to determine the optimal scheme. The results showed that single disc cutter is the best cutting method. An improved disc cutter with variable sliding angle is designed. In order to study the effects of the different structure parameters on the performance of the pruning machine and get the optimal combination of parameters, the orthogonal test was conducted. Forward speed, rotational speed of cutter, number of blades, cutting angle and knife-edge angle as factors, and the quality of pruning was selected as the evaluation index. The experiment results indicated that the working performance of machine was the highest when the number of blades was 6, rotational speed of cutter was 2000 rpm, cutting angle was 20°, knife-edge angle was 10°, forward speed was 0.5 m s−1. The average quality of pruning index, miss cutting index and tearing index were 90.6%, 5.68% and 3.72%, respectively. The designed machine can meet the agronomic requirements of Yunnan edible rose pruning operation. The research provides a reference for the design and extending of the pruning machine for edible rose.
Fast calculation of hydrogen-bond strengths and free energy of hydration of small molecules
Authors: Ghiandoni Gian Marco , Caldeweyher Eike 
Published: March 2023

AbstractHydrogen bonding is an interaction of great importance in drug discovery and development as it may significantly affect chemical and biological processes including the interaction of small molecules with other molecules, proteins, and membranes. In particular, hydrogen bonding can impact drug-like properties such as target affinity and oral availability which are critical to developing effective pharmaceuticals, and therefore, numerous methods for the calculation of properties such as hydrogen-bond strengths, free energy of hydration, or water solubility have been proposed over time. However, the accessibility to efficient methods for the predictions of such properties is still limited. Here, we present the development of Jazzy, an open-source tool for the prediction of hydrogen-bond strengths and free energies of hydration of small molecules. Jazzy also allows the visualisation of hydrogen-bond strengths with atomistic resolution to support the design of compounds with desired properties and the interpretation of existing data. The tool is described in its implementation, parameter fitting, and validation against two data sets of experimental hydration free energies. Jazzy is also applied against two chemical series of bioactive compounds to show that hydrogen-bond strengths can be used to understand their structure–activity relationships. Results from the validations highlight the strengths and limitations of Jazzy, and suggest its suitability for interactive design, screening, and machine-learning featurisation.
Progressive daily hopping exercise improves running economy in amateur runners: a randomized and controlled trial
Authors: Engeroff Tobias , Kalo Kristin , Merrifield Ryan , Groneberg David , Wilke Jan 
Published: March 2023

AbstractThis study investigated the effects of a daily plyometric hopping intervention on running economy (RE) in amateur runners. In a randomized, controlled trial, thirty-four amateur runners (29 ± 7 years, 27 males) were allocated to a control or a hopping exercise group. During the six-week study, the exercise group performed 5 min of double-legged hopping exercise daily. To progressively increase loading, the number of hopping bouts (10 s each) was steadily increased while break duration between sets was decreased. Pre- and post-intervention, RE, peak oxygen uptake (VO2peak), and respiratory exchange ratio (RER) were measured during 4-min stages at three running speeds (10, 12, and 14 km/h). ANCOVAs with baseline values and potential cofounders as cofactors were performed to identify differences between groups. ANCOVA revealed an effect of hopping on RE at 12 km/h (df = 1; F = 4.35; p < 0.05; η2 = 0.072) and 14 km/h (df = 1; F = 6.72; p < 0.05; η2 = 0.098), but not at 10 km/h (p > 0.05). Exercise did not affect VO2peak (p > 0.05), but increased RER at 12 km/h (df = 1; F = 4.26; p < 0.05; η2 = 0.059) and 14 km/h (df = 1; F = 36.73; p < 0.001; η2 = 0.520). No difference in RER was observed at 10 km/h (p > 0.05). Daily hopping exercise is effective in improving RE at high running speeds in amateurs and thus can be considered a feasible complementary training program.Clinical trial registration German Register of Clinical Trials (DRKS00017373).
Gecko-inspired self-adhesive packaging for strain-free temperature sensing based on optical fibre Bragg gratings
Authors: Liu Shuochao , Zhu Pingyu , Xie Fumin , Soto Marcelo A. 
Published: March 2023

AbstractThe large development of fibre Bragg gratings (FBGs) over decades has made this kind of structures one of the most mature optical fibre sensing technologies existing today, demonstrating key features for a very wide range of applications. FBG sensors are fragile and must be normally protected for real-field applications, although challenging packaging designs are required to mitigate temperature-strain cross-sensitivity issues. Here, a polydimethylsiloxane (PDMS) packaging with a microarray structure that provides gecko-inspired dry adhesion is proposed for strain-free FBG-based temperature sensing. Besides offering protection, the PDMS packaging with an embedded polyamide capillary damps the mechanical strain transferred to the optical fibre, providing FBG-based temperature sensing with a negligible impact of strain. In addition, the microarray structure imprinted on one surface of the packaging provides gecko-inspired dry adhesion based on van der Waals forces. This feature enables the packaged optical fibre sensor to be attached and detached dynamically to nearly any kind of smooth surface, leaving no residuals in the monitored structure. Experimental results verify a fast and accurate temperature response of the sensor with highly mitigated impact of residual strain. The proposed packaged sensor can be used in application where glue is not allowed nor recommendable to be used.
Systematic review of NTRK 1/2/3 fusion prevalence pan-cancer and across solid tumours
Authors: O’Haire Sophie , Franchini Fanny , Kang Yoon-Jung , Steinberg Julia , Canfell Karen , Desai Jayesh , Fox Stephen , IJzerman Maarten 
Published: March 2023

AbstractNTRK gene fusions are rare somatic mutations found across cancer types with promising targeted therapies emerging. Healthcare systems face significant challenges in integrating these treatments, with uncertainty in prevalence and optimal testing methods to identify eligible patients. We performed a systematic review of NTRK fusion prevalence to inform efficient diagnostic screening and scale of therapeutic uptake. We searched Medline, Embase and Cochrane databases on 31/03/2021. Inclusion criteria were studies reporting fusion rates in solid tumours, English language, post-2010 publication and minimum sample size. Critical appraisal was performed using a custom 11-item checklist. Rates were collated by cancer type and pooled if additional synthesis criteria were met. 160 studies were included, with estimates for 15 pan-cancer and 429 specific cancer types (63 paediatric). Adult pan-cancer estimates ranged 0.03–0.70%, with higher rates found in RNA-based assays. In common cancers, rates were consistently below 0.5%. Rare morphological subtypes, colorectal microsatellite instability, and driver mutation exclusion cancers had higher rates. Only 35.6% of extracted estimates used appropriate methods and sample size to identify NTRK fusions. NTRK fusion-positive cancers are rare and widely distributed across solid tumours. Small-scale, heterogeneous data confound prevalence prediction. Further large-scale, standardised genomic data are needed to characterise NTRK fusion epidemiology.
Transcranial focused ultrasound-mediated unbinding of phenytoin from plasma proteins for suppression of chronic temporal lobe epilepsy in a rodent model
Authors: Kim Evgenii , Kim Hyun-Chul , Van Reet Jared , Böhlke Mark , Yoo Seung-Schik , Lee Wonhye 
Published: March 2023

AbstractThe efficacy of many anti-epileptic drugs, including phenytoin (PHT), is reduced by plasma protein binding (PPB) that sequesters therapeutically active drug molecules within the bloodstream. An increase in systemic dose elevates the risk of drug side effects, which demands an alternative technique to increase the unbound concentration of PHT in a region-specific manner. We present a low-intensity focused ultrasound (FUS) technique that locally enhances the efficacy of PHT by transiently disrupting its binding to albumin. We first identified the acoustic parameters that yielded the highest PHT unbinding from albumin among evaluated parameter sets using equilibrium dialysis. Then, rats with chronic mesial temporal lobe epilepsy (mTLE) received four sessions of PHT injection, each followed by 30 min of FUS delivered to the ictal region, across 2 weeks. Two additional groups of mTLE rats underwent the same procedure, but without receiving PHT or FUS. Assessment of electrographic seizure activities revealed that FUS accompanying administration of PHT effectively reduced the number and mean duration of ictal events compared to other conditions, without damaging brain tissue or the blood–brain barrier. Our results demonstrated that the FUS technique enhanced the anti-epileptic efficacy of PHT in a chronic mTLE rodent model by region-specific PPB disruption.