bluuebunny/crossref_metadata_2025_split huggingface dataset:
Climate and management changes drove more stress-tolerant and less competitive plant communities in 40 years
Authors: Bopp Marie-Charlotte , Kazakou Elena , Metay Aurélie , Maillet Jacques , Quidoz Marie-Claude , Genty Léa , Fried Guillaume 
Published: August 2023

AbstractSpontaneous plant communities have undergone considerable constraints due to human-mediated changes. Understanding how plant communities are shifting in response to land management and climate changes is necessary to predict future ecosystem functioning and improve the resilience of managed ecosystems, such as agroecosystems. Using Mediterranean weed communities as models of managed plant communities in a climate change hotspot, we quantified to which extent they have shifted from the 1980s to the 2020s in response to climate and management changes in vineyards. In four decades, the annual range of temperatures (i.e.the difference between the warmest month’s and the coldest month’s mean temperatures) increased by 1.2°C and the summer temperatures by 2°C. Weed management diversified over time with the adoption of mowing that replaced the chemical weeding of inter-rows. Current weed communities were 41% more abundant, 24% more diverse and with a less even distribution of abundance across species than the 1980s communities at the vineyard level. Modern communities were composed of more annual species (57% of annual species in the 1980s versus 80% in the 2020s) with lower lateral spreadability and seed mass and were composed of fewer C4 species. They had higher community-weighted specific leaf area, higher leaf dry matter content and lower leaf area than 1980s weed communities. At the community level, the onset of flowering was earlier and the duration of flowering was longer in the 2020s. Climate change induced more stress-tolerant communities in the 2020s while the diversification of weed management practices over time filtered less competitive communities. This study shows that plant communities are adapting to climate change and that land management is a strong lever for action to model more diverse and functional plant communities in the future.
Broad-spectrum antiviral activity of clinically approved CYP3A inhibitors against pathogenic human coronaviruses in vitro
Authors: Gallucci Lara , Bazire James , Davidson Andrew D , Shytaj Iart Luca 
Published: August 2023

AbstractCoronaviruses pose a permanent risk of outbreaks, with three highly pathogenic species and strains (SARS-CoV, MERS-CoV, SARS-CoV-2) having emerged in the last twenty years. Limited antiviral therapies are currently available and their efficacy in randomized clinical trials enrolling SARS-CoV-2 patients has not been consistent, highlighting the need for more potent treatments. We previously showed that cobicistat, a clinically approved inhibitor of Cytochrome P450-3A (CYP3A), has direct antiviral activity against early circulating SARS-CoV-2 strainsin vitroand in Syrian hamsters. Cobicistat is a derivative of ritonavir, which is co-administered as pharmacoenhancer with the SARS-CoV-2 protease inhibitor nirmatrelvir, to inhibit its metabolization by CPY3A and preserve its antiviral efficacy. Here, we used automated imaging and analysis for a screening and parallel comparison of the anti-coronavirus effects of cobicistat and ritonavir. Our data show that both drugs display antiviral activity at low micromolar concentrations against multiple SARS-CoV-2 variantsin vitro, including epidemiologically relevant Omicron subvariants. Despite their close structural similarity, we found that cobicistat is more potent than ritonavir, as shown by significantly lower EC50 values in monotherapy and higher levels of viral suppression when used in combination with nirmatrelvir. Finally, we show that the antiviral activity of both cobicistat and ritonavir is maintained against other human coronaviruses, including HCoV-229E and the highly pathogenic MERS-CoV. Overall, our results demonstrate that cobicistat has more potent anti-coronavirus activity than ritonavir and suggest that dose adjustments could pave the way to the use of both drugs as broad-spectrum antivirals against highly pathogenic human coronaviruses.
Harnessing Agent-Based Modeling in CellAgentChat to Unravel Cell-Cell Interactions from Single-Cell Data
Authors: Raghavan Vishvak , Li Yue , Ding Jun 
Published: August 2023

ABSTRACTUnderstanding cell-cell interactions (CCIs) is essential yet challenging due to the inherent intricacy and diversity of cellular dynamics. Existing approaches often analyze global patterns of CCIs using statistical frameworks, missing the nuances of individual cell behavior due to their focus on aggregate data. This makes them insensitive in complex environments where the detailed dynamics of cell interactions matter. We introduce CellAgentChat, an agent-based model (ABM) designed to decipher CCIs from single-cell RNA sequencing and spatial transcriptomics data. This approach models biological systems as collections of autonomous agents governed by biologically inspired principles and rules. Validated against seven diverse single-cell datasets, CellAgentChat demonstrates its effectiveness in detecting intricate signaling events across different cell populations. Moreover, CellAgentChat offers the ability to generate animated visualizations of single-cell interactions and provides flexibility in modifying agent behavior rules, facilitating thorough exploration of both close and distant cellular communications. Furthermore, CellAgentChat leverages ABM features to enable intuitive in silico perturbations via agent rule modifications, pioneering new avenues for innovative intervention strategies. This ABM method empowers an in-depth understanding of cellular signaling interactions across various biological contexts, thereby enhancing in-silico studies for cellular communication-based therapies.
Clinical investigations to evaluate high-risk orthopaedic devices: systematic review of the peer-reviewed medical literature
Authors: Lübbeke Anne , Combescure Christophe , Barea Christophe , Gonzalez Amanda Inez , Tucker Keith , Kjærsgaard-Andersen Per , Melvin Tom , Fraser Alan G , Nelissen Rob , Smith James A 
Published: August 2023

AbstractPurposeThe objective of this systematic review was to give an overview of clinical investigations regarding hip and knee arthroplasty implants published in peer-reviewed scientific medical journals before entry into force of the EU Medical Device Regulation in May 2021.MethodsWe systematically reviewed the medical literature for a random selection of hip and knee implants, to identify all peer-reviewed clinical investigations published within 10years before and up to 20years after regulatory approval. We report study characteristics, methodologies, outcomes, measures to prevent bias, and timing of clinical investigations, of 30 current implants. The review process was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines.ResultsWe identified 2912 publications and finally included 151 papers published between 1995 and 2021 (63 on hip stems, 34 on hip cups, 54 on knee systems). We identified no clinical studies published before CE-marking for any selected device, and no studies even up to 20 years after CE-marking in one quarter of devices. There were very few randomized controlled trials, and registry-based studies generally had larger sample sizes and better methodology.ConclusionsThe peer-reviewed literature alone is insufficient as source of clinical investigations of these high-risk devices intended for life-long use. A more systematic, efficient and faster way to evaluating safety and performance is necessary. Using a phased introduction approach, nesting comparative studies of observational and experimental design in existing registries, increasing use of benefit measures, and accelerating surrogate outcomes research, will help to minimise risks and maximise benefits.
Distinct COVID-19 vaccine combinations result in divergent immune responses
Authors: Zaeck Luca M. , Tan Ngoc H. , Rietdijk Wim J.R. , Geers Daryl , Sablerolles Roos S.G. , Bogers Susanne , van Dijk Laura L.A. , Gommers Lennert , van Leeuwen Leanne P.M. , Rugebregt Sharona , Goorhuis Abraham , Postma Douwe F. , Visser Leo G. , Dalm Virgil A.S.H. , Lafeber Melvin , Kootstra Neeltje A. , Huckriede Anke L.W. , Haagmans Bart L. , van Baarle Debbie , Koopmans Marion P.G. , van der Kuy P. Hugo M. , GeurtsvanKessel Corine H. , de Vries Rory D. ,   SWITCH-ON Research Group
Published: August 2023

SummaryWaning antibody responses after COVID-19 vaccination combined with the emergence of the SARS-CoV-2 Omicron lineage led to reduced vaccine effectiveness. As a countermeasure, bivalent mRNA-based booster vaccines encoding the ancestral spike protein in combination with that of Omicron BA.1 or BA.5 were introduced. Since then, BA.2-descendent lineages have become dominant, such as XBB.1.5 or BA.2.86. Here, we assessed how different COVID-19 priming regimens affect the immunogenicity of the recently used bivalent booster vaccinations and breakthrough infections. BA.1 and BA.5 bivalent vaccines boosted neutralizing antibodies and T-cells up to 3 months after boost; however, cross-neutralization of XBB.1.5 was poor. Interestingly, different combinations of prime-boost regimens induced divergent responses: participants primed with Ad26.COV2.S developed lower binding antibody levels after bivalent boost while neutralization and T-cell responses were similar to mRNA-based primed participants. In contrast, the breadth of neutralization was higher in mRNA-primed and bivalent BA.5 boosted participants. Combined, we highlight important ‘lessons learned’ from the employed COVID-19 vaccination strategies. Our data further support the use of monovalent vaccines based on circulating strains when vaccinating risk groups, as recently recommended by the WHO. We emphasize the importance of the continuous assessment of immune responses targeting circulating variants to guide future COVID-19 vaccination policies.
Experimental and computational study of imidazole-pyridine and its derivatives as corrosion inhibitors on brass in sulfuric acid solution
Authors: Zhou Xin , Zhou Wenbin , Zhang Yang Zheng , Li Meng-Ran , Sun Haijing , Sun Jie 
Published: August 2023

Purpose
This paper aims to study the corrosion inhibition behavior of imidazopyridine and its three derivatives on brass.

Design/methodology/approach
The authors performed weight loss experiments, electrochemical experiments including the polarization curve and electrochemical impedance spectrum, corrosion morphology observation using scanning electron microscope (SEM) and atomic force microscope (AFM) and surface composition analysis via X-ray photoelectron spectroscopy (XPS) to analyze the corrosion inhibition behavior of imidazopyridine and its three derivatives on brass by using quantum chemical calculation (Gaussian 09), molecular dynamics simulation (M-S) and Langmuir adsorption isotherm.

Findings
According to the results, imidazole-pyridine and its derivatives were found to be modest or moderately mixed corrosion inhibitors; moreover, they were spontaneously adsorbed on the metal surface in a single-layer, mixed adsorption mode.

Originality/value
The corrosion inhibition properties of pyrazolo-[1,2-a]pyridine and its derivatives on brass in sulfuric acid solution were analyzed through weight loss and electrochemical experiments. Moreover, SEM and AFM were simultaneously used to observe the corrosion appearance. Furthermore, XPS was used to analyze the surface. Then, Gaussian 09 and M-S were combined along with the Langmuir adsorption isotherm to investigate the corrosion inhibition mechanism of imidazole-[1,2-a]pyridine and its derivatives.
On the field uniformity of reverberation chambers – a global sensitivity analysis study
Authors: Kenderes Anett , Gyimóthy Szabolcs , Benkő Péter Tamás 
Published: August 2023

Purpose
Global sensitivity analysis (SA) by means of Sobol’ indices enhanced with different surrogate modeling techniques is performed in this work. The purpose is to investigate the influence of measurement uncertainties and the environment characteristics themselves on the desired field uniformity in reverberation chambers (RCs). This yields an efficient apparatus for the stirring and chamber design process.

Design/methodology/approach
The technique of Sobol’ indices, as a candidate of global SA methods, is suitable for high fluctuations due to its robustness, which can be addressed to the stochastic nature of the RC environment. The aim of using surrogate modeling techniques is to compute the indices efficiently with a moderate number of required simulations. The powerfulness of this approach is introduced in a simple numerical example in which the physical phenomena can be identified more straightforwardly.

Findings
This method can provide useful knowledge in the lower frequency range, where the ideal properties of the electromagnetic field in RCs cannot be established, and the importance of the setup parameters can vary from configuration to configuration. In addition, it can serve as a basis for setup adaptation during parallelized electromagnetic compatibility tests, which would result in a more time- and cost-saving option in industrial applications in the future.

Originality/value
Despite the previous attempts, a profound investigation of multiple setup parameters is still a hot topic. The main contribution of this work is the extension of the application area of the method of Sobol’ indices to RCs, which has not been done so far.
What is the connection between Fintechs’ video marketing and their vulnerable customers’ brand engagement during crises?
Authors: Sakas Damianos P. , Giannakopoulos Nikolaos T. , Terzi Marina C. , Kamperos Ioannis Dimitrios G. , Kanellos Nikos 
Published: August 2023

Purpose The paper’s main goal is to examine the relationship between the video marketing of financial technologies (Fintechs) and their vulnerable website customers’ brand engagement in the ongoing coronavirus disease 2019 (COVID-19) crisis.Design/methodology/approach To extract the required outcomes, the authors gathered data from the five biggest Fintech websites and YouTube channels, performed multiple linear regression models and developed a hybrid (agent-based and dynamic) model to assess the performance connection between their video marketing analytics and vulnerable website customers’ brand engagement.Findings It has been found that video marketing analytics of Fintechs’ YouTube channels are a decisive factor in impacting their vulnerable website customers’ brand engagement and awareness.Research limitations/implications By enhancing video marketing analytics of their YouTube channels, Fintechs can achieve greater levels of vulnerable website customers’ engagement and awareness. Higher levels of vulnerable customers’ brand engagement and awareness tend to decrease their vulnerability by enhancing their financial knowledge and confidence.Practical implications Fintechs should aim to increase the number of total videos on their YouTube channels and provide videos that promote their customers’ knowledge of their services to increase their brand engagement and awareness, thus reducing their vulnerability. Moreover, Fintechs should be aware not to over-post videos because they will be in an unfavorable position against their competitors.Originality/value This research offers valuable insights regarding the importance of video marketing strategies for Fintechs in promoting their vulnerable website customers’ brand awareness during crisis periods.
Comparative approach in public health social security: a legal case study of the Indonesian, France, and Singapore health systems
Authors: Paluttri Sukri 
Published: August 2023

Purpose
This research paper aimed to study the legal structure of top-performing health governance systems and compare them with the Indonesian health social security system to identify the main differences and provide recommendations for Indonesian and other developing countries’ health policymakers and administrators.

Design/methodology/approach
Using formative research with a conceptual approach and statute approach as method in this study. Data was gathered using the document study technique, which studies various documents, especially legal documents related to health law, linked to legal purpose theories. Moreover, the World Health Organization ranking was considered to choose the two countries (France and Singapore) with a high social health security system for comparative analysis. All data collected has been analyzed using a qualitative and theoretical basis. Content analysis was performed by analyzing the legal documents, and the regulatory framework of all three countries was deeply analyzed to draw conclusions and recommendations.

Findings
Indonesia has specific laws to implement a social security system in the health sector. However, the lack of the best medical facilities and infrastructure and weak implementation of existing laws were identified as major reasons behind the poor health security system compared to comparative countries. Also, as a developing nation Indonesian Government face budgetary pressures and huge population challenges to meet required standards. Thus, the financing approaches used by Singapore and France may help developing countries meet these challenges effectively. Therefore, there is a dire need to strengthen the social health security system all over the country with amendments to laws and ensure the implementation of prevailing laws and regulations.

Practical implications
Providing understanding related to the social security health system in Indonesia along with a detailed description of the sound social health security system in France and Singapore will further provide an avenue for the researchers to critically analyze this line of study to devise some valuable suggestions further and to draw loopholes in the system.

Originality/value
A comparative approach for legal studies in the health sector is rare. So, this research advanced the social security health system-related literature and legal studies on the health sector by using this comparative approach to develop policy insights and future research directions, which will further help the field to grow.
Bridges: a tourist attraction and iconic element at urban cities’ tourism promotion websites
Authors: Florido-Benítez Lázaro 
Published: August 2023

Purpose
The nuclear purpose of this research paper is to analyse representative bridges around the world as a tourist attraction and iconic element through destination marketing organisations’ (DMOs’) tourism official websites where these are localised and three online travel agencies’ (OTAs’) websites.

Design/methodology/approach
This research used a mixed method. The author carried out Google research (13 March 2023) that included the following search word string “iconic bridges around the world” and “the most famous bridges worldwide” to select the most relevant bridges around the globe. Moreover, this research used a content analysis to examine how Expedia, Booking and Orbitz OTAs promote the bridges through their websites in terms of a tourist attraction, iconic element, tourist package, images and information.

Findings
Findings suggest that the most representative bridges analysed in this study are promoted as iconic element and tourist attraction through DMOs’ websites. Nevertheless, Booking, Expedia and Orbitz OTAs promote and sell products and services related to bridges selected, except in the case of the Millau Viaduct in France, the Si-O-Se-Pol bridge in Iran, the Danyang Kunshan Grand bridge in China and the Royal Gorge in the USA. Furthermore, results support that OTAs need to enhance the quality and variety of products and services that are linked to iconic bridges sightseeing tours because at the moment, there is a great uniformity in the promotion of products and services provided.

Originality/value
This paper contributes to broader debates in the importance of bridges as a tourist attraction and iconic element to attract tourists through tourism promotion websites.
Improving ethical usage of corporate data in higher education: Enhanced Enterprise Data Ethics Framework
Authors: McNicol Trinity , Carthouser Bailey , Bongiovanni Ivano , Abeysooriya Sasenka 
Published: August 2023

PurposeThe purpose of this study is to address the generalised lack of guidance on ethical treatment of corporate (e.g. non-research) data in higher education institutions, by focusing on the case of the University of Queensland (Brisbane, Australia). No actionable framework is currently available in the country to govern the ethical usage of corporate data. As such, this research takes a stakeholder-centred approach to data ethics; the lived experience of the stakeholders involved coupled with a theory-based ethical framework allowed the authors build to build a framework to guide ethical data practice.Design/methodology/approachAdopting a revised canonical action research approach focused on intervention on the context, the authors conducted a review of the literature on ethical usage of data in higher education institutions; administered one survey to university students (n = 168); and facilitated three workshops with professional staff (two) and students (one).FindingsCollected data highlighted how, among other themes, the role and ethical importance of transparency was the dominant claim among all stakeholder groups. Findings helped the authors develop an Enhanced Enterprise Data Ethics Framework (EEDEF) emphasising transparency and stakeholder-centricity.Practical implicationsLegislation is the driver to regulate the use of corporate data in higher education; however, this can be problematic because legislation is retrospective, lacks normativity and offers scarce directions for cases that do not exactly follow within the legislative mandate. In light of these regulatory limitations, the authors’ EEDEF offers operators guidance on how to ethically manage corporate data in the higher education environment.Originality/valueThis study fills gaps in praxis and theory; that is the lack of literature and guiding ethical frameworks to inform data practice in higher education. This research fosters a more ethical data management by virtue of genuine and authentic engagement with stakeholders and emphasises the importance of strategic decision-making and maturity of data culture in the higher education sector.