bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diagnostic and prognostic value of circulating tumor cells in Indian women with suspected ovarian cancer
Authors: Singh Swarnima , Kumar Uday 
Published: April 2023

ABSTRACT

Background:
“Liquid biopsy,” where body fluids are screened for biomarkers, is gathering substantial research. We aimed to examine women with suspected ovarian cancer for the presence of circulating tumor cells (CTCs) and study its role in prediction of chemoresistance and survival.

Methods:
Magnetic powder labeled monoclonal antibodies for epithelial cell adhesion molecule (EpCAM), mucin 1 cell surface associated, mucin 16 cell surface associated, or carbohydrate antigen 125 (CA125), were prepared according to the manufacturer’s protocol. Expression of three ovarian cancer related genes was detected in CTCs using multiplex reverse transcriptase-polymerase chain reaction. CTCs and serum CA125 were measured in 100 patients with suspected ovarian cancer. Correlations with clinicopathological parameters and treatment were analyzed.

Results:
CTCs were detected in 18/70 (25.7%) of women with malignancy compared to 0/30 (0.0%) in those with benign gynecologic diseases (P = 0.001). The sensitivity and specificity of the CTC test for predicting a malignant histology in pelvic masses were 27.7% (95% CI: 16.3%, 37.7%) and 100% (95% CI: 85.8%, 100%), respectively. The number of CTCs correlated with stage of ovarian cancer (P = 0.030). The presence of EpCAM + CTC at primary diagnosis in ovarian cancer was found to be an independent predictor of a poor progression free survival (HR, 3.3; 95% CI, 1.3–8.4; P = 0.010), overall survival (HR, 2.6; 95% CI,1.1–5.6; P = 0.019), and resistance to chemotherapy (OR 8.6; 95% CI, 1.8–43.7; P = 0.009).

Conclusion:
Expression of EpCAM + CTC in ovarian cancer predicts platinum resistance and poor prognosis. This information could be further used in investigating anti-EpCAM-targeted therapies in ovarian cancer.
Treatment options in primary mediastinal B cell lymphoma patients, retrospective multicentric analysis; a Turkısh oncology group study
Authors: Acar Ramazan , Paydaş Semra , Yıldırım Murat , Kılıçarslan Emrah , Sahın Ugur , Dogan Ali , Guven Deniz C. , Ekıncı Omer , Tıglıoglu Mesut , Erdogan Isıl , Elıbol Tayfun , Kızıloz Halil , Aykan Musa B. , Sayın Selim , Kaptan Kursat , Soydan Ender , Gokmen Ayla , Esen Ramazan , Barısta Ibrahim , Albayrak Murat , Erturk Ismail , Yıldız Birol , Keskın Gulsema Y. , Aylı Meltem , Karadurmus Nuri 
Published: April 2023

Abstract

Introduction and Aim:
Primary mediastinal B-cell lymphomas (PMBL) are aggressive B- cell lymphomas. Although the initial treatment models vary in PMBL, appropriate treatment methods are not known. We aim to show real-life data on health outcomes in adult patients with PMBL who received various type of chemoimmunotherapies in Turkey.

Method:
We analyzed the data of 61 patients who received treatments for PMBL from 2010 to 2020. The overall response rate (ORR), overall survival (OS) and progression-free survival (PFS) of the patients were evaluated.

Results:
61 patients were observed in this study. The mean age of the study group was 38.4 ± 13.5 years. From among them, 49.2% of the patients were female (n = 30). For first-line therapy, 33 of them had received rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) regimen (54%). Twenty-five patients had received rituximab, etoposide, prednisone, vincristine, cyclophosphamide and doxorubicin (DA-EPOCH-R) regimen. The ORR was 77%. The median OS and PFS were as follows: 25 months (95% CI: 20.4–29.4) and 13 months (95% CI: 8.6–17.3), respectively. The OS and PFS at 12 months were 91.3% and 50%, respectively. The OS and PFS at five years were 64.9% and 36.7%, respectively. Median follow-up time period was 20 months (IQR 8.5–38.5).

Conclusion:
R-CHOP and DA-EPOCH-R showed good results in PMBL. These remain one of the best determined systemic treatment options for first-line therapy. Also, the treatment was associated with good efficacy and tolerability.
To study the pattern of seroconversion for SARS-CoV-2 IgG antibodies in COVID-infected cancer patients and to correlate it clinically – A cross-sectional study
Authors: Gupta Surabhi , Chauhan Nitu , Kumari Pratibha , Bansal Manish , Chahar Ajeet 
Published: April 2023

ABSTRACT

Background:
Though as per literature cancer is also consider an associated risk factor for morbidity and mortality for covid infection but practically most of the cancer patients showed no symptoms with less mortality in second wave of pandemic. So this cross sectional comparative analysis study was designed to see the prevalence of sero-conversion for SARS –coV for IgG in covid infected cancer patients and to compare the IgG antibodies level between covid infected cancer patients and covid infected healthy persons.

Material and Method:
Covid-19 antibody screening of covid recovered cancer patients as well as covid recovered healthy persons was done in department of Transfusion Medicine.IgG antibody for COVID-19 was detected using microtiter plate with whole-cell antigen coating, an in-house validated kit by NIV ICMR3. Prevalence of sero-conversion was noted down in both the groups and compared.

Result:
There was more infectivity rate in second covid wave. Case fatality rate was much lesser as compared to 1st wave in cancer patients. In cancer patients maximum seroconversion was seen in younger group i.e. 21-30 yrs. of age, this was in contrast to finding in general population, where minimum seroconversion was seen in younger age group. It was observed that more prevalence of sero conversion was seen in general population as compared to cancer patients, but difference was non-significant.

Conclusion:
Though cancer patients showed less rate of seroconversion as compared to normal healthy person, but none of them showed any moderate or severe symptoms inspite of being a risk factor for severity of covid. Though larger study are required to comment on statistical conclusion.
An immunohistochemical evaluation of tumor-associated macrophages (M1 and M2) in carcinoma prostate – An institutional study
Authors: Hadimani Soumya M. , Das Subhashish , Harish K. G 
Published: April 2023

ABSTRACT

Background:
Tumor-associated macrophages (TAM) are the main component of inflammation along with leukocytes, endothelial cells and fibroblasts together form a tumor microenvironment, with immune cells representing its vital component. Many studies suggested that TAMs cumulating in tumors correlate with a poor prognosis. In prostate cancer, TAMs can increase cancer cell invasion by stimulating tumor angiogenesis, degrading the extracellular matrix, and also suppresses the antitumor functions of cytotoxic T cells resulting in poor prognosis.

Aims and Objectives:
1. To determine the expression of M1 (CD68) and M2 (CD163) in prostate carcinoma (Pca). 2. To find the association between M1, M2 macrophage with Gleason’s score and stage of Pca.

Materials and Methods:
This is a retrospective observational study. All transurethral resection prostatic (TURP) chips positive for Pca and the clinical details were collected. Radiologic findings with respect to stage of disease, size of lesion, were noted.

Results:
Among the 62 cases studied, majority of the cases were in-between the age of 61–70 years. Highest cases were seen in Gleason’s score 8, 9, and 10 (62%), prostatic specific antigen (PSA) levels 20–80 ng/mL (64%), tumor size 3–6 cm (51.6%), T3 stage (40.3%), N1 lymph node stage (70.9%). M1 stage of (31%). CD68 and CD163 expression was analyzed with Gleason’s score, TNM stage and PSA levels. CD68 score 3 correlated with low distant and nodal metastasis 6.2% and 6.8%, respectively. CD163 score 3 correlated with high metastasis to lymph nodes and distant metastasis of 86.3% and 25%, respectively. On further analysis, statistically convincing association between the CD163 expression and Gleason’s score, PSA levels, nodal and distant metastasis was found.

Conclusion:
CD68 expression was correlated with good prognosis with less nodal and distant metastasis and Cd163 expression has poor outcome with increased chances of nodal and distant metastasis. Further exploration of TAM mechanisms and immune checkpoints in the prostate tumor microenvironment can furnish new light and motives for the treatment of Pca.
An immunohistochemical study of double-expressor lymphomas and its correlation with cell of origin
Authors: Ananthamurthy Anuradha 
Published: April 2023

Abstract

Background:
Diffuse large B cell Lymphomas (DLBCL) that co express C MYC and BCL 2 are known as ‘double expressor lymphomas’ and are believed to have a worse prognosis than other diffuse large B cell lymphomas. This was a study to assess the frequency of double expressor lymphomas in our cohort of DLBCL

Aims and Objectives:
The aims of this study were to assess the frequency of double expression of C MYC and BCL 2 in cases of DLBCL and to correlate the same with clinicopathological parameters including cell of origin, namely germinal centre type versus non germinal centre type.

Materials and Methods:
This was a retrospective observational study Immunostaining for MYC antibody and BCL2 were performed using the standard polymer/DAB technique. 40% for MYC and 50% for BCL2 were taken as cut off values.Chi square analysis was used to compare the variables, and a p value of less than 0.05 was taken as statistically significant

Results:
Of 40 cases studied, 11 (27.5%) were double expressors. There was no significant correlation of double expression with gender, site (nodal versus extra nodal), cell of origin namely germinal centre/non germinal centre types and Ki67 index when compared to the other group which did not show double expression

Conclusions:
Immunohistochemistry is a useful technique to detect double expressor lymphomas which are known to have an aggressive course. Cell of origin did not show significant correlation with double expression in our study.
Prognostic relevance of pre-treatment inflammatory biomarkers along with other clinicopathological and treatment factors in oral cavity cancers
Authors: Kothandaraman Shri Kamakshi , Krishnamurthy Arvind , Mittal Saket , Ramshankar Vijayalakshmi 
Published: April 2023

Abstract

Background:
Inflammation has traditionally been considered to be one of the hallmarks of cancer, and systemic inflammatory responses have a prognostic value in many solid cancers. The use of inflammation-based prognostic markers along with traditional clinicopathological prognostic markers in oral cavity cancers has not been studied well.

Materials and Methods:
This is a retrospective study from a prospectively maintained database of patients with oral cancers who were managed in a regional cancer center in south India. The study included patients with squamous cell carcinoma of the oral cavity who were treated with curative intent from January to December 2016.

Results and Discussion:
Three hundred sixty-one patients met the eligibility criteria and were included in the study. The median age of our patient cohort was 45 years; the male-to-female ratio was 3.7:1. All of the patients underwent curative treatments after a multi-disciplinary board concurrence. Advanced T stage, patients with buccal mucosal cancers and patients who received upfront non-surgical treatments have poorer survival outcomes. The clinicopathological variables that predicted a poorer overall survival in the cohort of patients treated with upfront surgery were advanced T Stage, higher grade, presence of perineural invasion, a higher inflammatory maker, and combination of platelet and neutrophil lymphocyte ratio (COP-NLR).

Conclusion:
Our unique study of oral cavity cancer patients with a primary aim of exploring the prognostic significance of the pre-treatment inflammatory markers gave very interesting results. The prognostic significance of COP-NLR and other inflammatory markers in oral cancers need to be further explored. More importantly, our study has clearly reiterated that meaningful long-term survival outcomes in oral cavity cancers can only be achieved with the incorporation of upfront surgery.
Alteration in key oncoprotein expression in gastric adenocarcinoma – An immunohistochemical study
Authors: Jain Pragya , Wadhwa Neelam , Diwaker Preeti , Joshi Mohit Kumar , Mishra Kiran 
Published: April 2023

ABSTRACT

Objective:
This study was conducted to evaluate the frequency and clinicopathologic correlates of human epidermal growth factor receptor 2 (HER-2)/neu and betacatenin (BC) oncoproteins in gastric adenocarcinoma and to seek correlation if any between their expression status.

Materials and Methods:
This cross-sectional analytical immunohistochemistry (IHC) study was performed on 50 cases of gastric adenocarcinoma. HER-2/neu immunoexpression was scored as per criteria by Ruschoff et al. as positive (3+), equivocal (2+), and negative (1+, 0). Aberrant BC expression was categorized as nuclear, cytoplasmic, and reduced membranous immunoexpression. Protein expression results of both oncoproteins were correlated with conventional clinicopathological parameters. Correlation between immunoexpression profiles of both proteins was also analyzed. P <0.05 was considered statistically significant.

Results:
HER-2/neu positivity (2 + and 3+) was seen in 94% of the cases; almost 60% had strong (3+) expression. All cases showed aberrant BC immunoexpression (any pattern) except 2 cases that revealed negative expression (a form of aberrant immunoexpression) and were removed from analysis due to a very small number. The pattern of BC expression was as follows: nuclear expression (38%), cytoplasmic expression (82%), reduced membranous expression (96%), no staining (4%) cases. HER-2/neu expression correlated with age. No significant correlation was found between any of the 2 oncoprotein immunoexpression and other clinicopathological parameters (P > 0.05). Concordance between protein expression of HER-2/neu and BC was seen in >93% cases, however, the correlation was not significant.

Conclusion:
HER-2/neu and BC oncoprotein expression are frequently dysregulated in gastric adenocarcinomas. The significance of pathways involving HER-2/neu and BC in gastric carcinogenesis should be explored.
Early endometrial carcinoma: Experience and outcomes
Authors: Goel Priyanka , Singh Vikram , Sharma Rakesh , Chaudhary Debashish , Chatterjee Abhishek , Dora Tapas , Sancheti Sankalp , Goel Alok , Khandelwal Sachin , Sali Akash Pramod , Kaur Harpreet , Guru Arvind , Kapoor Rakesh 
Published: April 2023

ABSTRACT

Aim:
Endometrial carcinoma (EC) data from India are very sparse. We did a retrospective analysis of our patients registered at this peripheral cancer center based in rural Punjab and studied their outcome.

Materials and Methods:
Ninety-eight Stage I and II EC patients with endometroid histology registered at our institute from January 2015 to April 2020 were studied for demography, histopathology, treatment received, and outcomes. FIGO 2009 staging and new European Society for Medical Oncology (ESMO) risk group classification was used.

Results:
Our patients had a median age of 60 years (range 32–93 years). There were 39 (39.8%), 41 (42.0%), 4 (4.1%), 12 (12.2%) patients in the low risk, intermediate risk (IR), high intermediate risk, and high risk groups, respectively, as per new ESMO risk classification. Two (2.0%) patients had incomplete information to assign them to a particular risk group. Fifty (46.7%) patients underwent complete surgical staging and 54 (50.5%) patients received adjuvant RT. With a median follow-up of 27.0 months, there were 1 locoregional and 2 distant recurrences. There were 8 deaths in total. Three-year overall survival for the entire group is 90.6%.

Conclusions:
The risk group determines adjuvant treatment in endometrial cancer. Patients operated at dedicated cancer center tend to have better surgical staging and thus better outcome because of better risk stratification and grouping for adjuvant therapy. IR histology was more common in our group of patients, which is variable as compared to available literature.
El director de arte publicitario. 80 años después de su nacimiento
Authors: Roca David 
Published: April 2023

En los años 20 aparece en la agencia de publicidad una nueva figura: el director de arte. Desde entonces hasta ahora, este profesional ha sufrido una constante evolución, que se rompe a partir de mediados de los '80 con la entrada de la autoedición en la agencia de publicidad. A partir de ese momento, el director de arte empieza a adquirir una creciente importancia en la profesión.
Este trabajo consiste en explicar cómo es esa "nueva" figura, en qué consiste su trabajo en la actualidad y cómo han cambiado las estructuras productivas desde que adquiere "poder" en el proceso creativo. El artículo se basa en un estudio cualitativo, que consistió en entrevistas personales a directores de arte de diferentes agencias de publicidad de Barcelona. La causa de llevar a cabo este estudio es la escasa biografía acerca de este tema.
Reabilitação com prótese dentogengival paciente Classe III – relato de caso
Authors: Romio Lucas 
Published: April 2023

As próteses dentogengivais, normalmente são propostas alternativas para casos com perda de estrutura periodontal, principalmente em região anterior de maxila Possibilitante grandes reabilitações estéticas, ou seja, mesmo com o avanço de técnicas cirúrgicas e evolução de biomateriais, alguns casos são limitados ou paciente não aceita a hipótese de passar por grandes procedimentos cirúrgicos. Neste relato de caso, embora não seja o ideal, garante uma reabilitação estética e funcional fixa satisfatória para o paciente que apresenta falta de elementos em região anterior de maxila. O planejamento reverso foi fundamental para ajudar no caso.
TANGGUNGJAWAB BANK TERHADAP PERLINDUNGAN BARANG AGUNAN KREDIT
Authors: Harefa Fajarius , Laia Yosafat , Marbun Jaminuddin , Hamonangan Alusianto 
Published: April 2023

Pelanggan maupun perusahaan meimiliki kaitan satu sama lain dalam pengertiannya perusahaan dan pelanggan adalah mempunyai peranan dalam melaksanakan kegiatan dalam perusahaan tersebut. Dan memiliki 2 dasar, adalah yang pertama kaitan peraturan yang kedua kaitan kepastian.. perusahaan merupakan suatu tempat untuk melaksanakan kegiatan dan menciptakan suatu produk serta meberikan penawaran kepada pelanggan. Rasa solidaritas harus dilaksanakan guna untuk memebrikan perlindungan kepada masyarakat atau individu untuk menjaga keselamatan dan hak setiap oramg. Dalam perkara ini diminta keseriusan bank dalam pertanggugjawaban barang agunan kredit terhadap nasabah, dalam melakukan pertanggungjawaban yang sepenuhnya dan perlindungan terhadap barang agunan kredit sehingga masyarakat merasa terpercaya dan terlindungi barang agunan kredit.
IMPLEMENTASI PERMOHONAN PENETAPAN KETERANGAN MENINGGAL DARI PENGADILAN NEGERI GUNA MENERBITKAN AKTA KEMATIAN TIDAK PERNAH DIDAFTARKAN PADA KANTOR CATATAN SIPIL (Studi putusan No.144/Pdt.P/2022/PN Tjk
Authors: Renaldi Antoni Barra , Erlina Erlina , Hesti Yulia 
Published: April 2023

Abstrak

Hukum mengatur hak serta kewajiban pada kehidupan bermasyarakat serta pula mengatur penegakan serta perlindungan hak serta kewajiban tadi. sesuai hasil penelitian serta pembahasan, tata cara permohonan akta kematian pada pengadilan negeri sesuai putusan No.144/Pdt.P/2022/PN Tjk. Sama menggunakan tahapan mempertimbangkan perkara perdata pada biasanya, seperti karena para pihak berkepentingan menghadap pengadilan negeri menggunakan membawa surat permohonan serta persyaratan lain serta bukti pengajuan surat tadi, maka pemohon pula wajib menghadirkan 2 orang saksi, atas kesaksiannya perihal permohonan akta kematian, konklusi serta akhirnya temuan hakim. Dampak hukum ditemukannya akta kematian oleh Pengadilan Negeri sesuai putusan No.144/Pdt.P/2022/PN Tjk, sebagai akibatnya Kantor Catatan Sipil Kota Bandar Lampung wajib membukukan kematian tadi pada buku catatan sipil, berlaku bagi rakyat negara Indonesia serta sekaligus bisa menerbitkan akta kematian atas nama Nurmala Sari serta keluarga almarhum bisa meminta diterbitkannya akta kematian sesuai menggunakan ketentuan peraturan perundang-undangan berlaku.
FORGIVING OF THE VICTIM AND/OR FAMILY TOWARDS THE PERPETRATOR AS A CONSIDERATION IN IMPOSING CRIMINAL AND PUNISHMENT ACCORDING TO THE LAW NUMBER 1 OF 2023 CONCERNING THE CRIMINAL CODE
Authors: Ali Tengku Mabar , Yopiza Yopiza , Rangkuti Putri Ramadhani 
Published: April 2023

Pemaafan korban dan /atau keluarga korban merupakan salah satu dasar pertimbangan di dalam menjatuhkan pemidanaan terhadap pelaku tindak pidana sebagaimana diatur dalam Pasal 54 ayat (1) huruf j UU No.1/2023 tentang KUHP. Adanya pemaafan dari korban dan/atau keluarganya terhadap pelaku, tidaklah berarti meniadakan dan atau menghapuskan pertanggungjawaban pidana pelaku. Akan tetapi, dalam penjatuhan pemidanaan terhadap pelaku, pemaafan korban dapat menjadi pertimbangan bagi hakim dalam menentukan berat ringannya putusan pidana yang akan dijatuhkan, di samping pertimbangan lainnya.Adanya pemafaaan dari korban terhadap pelaku tindak pidana dapat menjadi pertimbangan yang meringankan bagi hakim dalam menjatuhkan putusan pemidanaan terhadap terdakwa.
PERTANGGUNGJAWABAN PIDANA PELAKU PENYEBARAN FOTO/VIDEO ASUSILA MELALUI MEDIA SOSIAL (Studi Putusan Nomor: 429/Pid.Sus/2022/PN.Tjk)
Authors: Zaini Zulfi Diane , Hesti Yulia , Ilham Igo 
Published: April 2023

Asusila merupakan perbuatan yang menyimpang dari norma-norma kesopanan yangMenggambarkan perbuatan dan pandangan si peleceh kepada yang dilecehkan dimana pandangan tersebut menghinakan, memandang rendah atau tidak berharga. Permasalahan penelitian mengenai faktor penyebab pelaku melakukan tindak pidana penyebaran foto/video asusila melalui media sosial dan pertanggungjawaban pidana pelaku penyebaran foto/video asusila melalui media sosial. Metode penelitian menggunakan: 1. pendekatan yuridis normatif dilaksanakan dengan mempelajari norma atau kaidah, 2. pendekatan empiris dilakukan dengan wawancara terhadap narasumber.Faktor penyebab terjadinya bahwa benar karena pelaku tidak terima karena Saksi korban ingin mengakhiri hubungan asmara dengan pelaku maka tanpa seijin dan sepengetahuan Saksi korban, pelaku telah menyebarkan luaskan gambar/foto/video asusila Saksi korban.Pertanggungjawaban pidana terhadap pelaku telah memenuhi semua unsur-unsur sesuai dengan dakwaan oleh penuntut umum dengan dakwaan yang berbentuk alternatif dari Pasal 27 ayat (1) UU ITE, Maka Hakim menjatuhkan pidana kepada pelaku dengan pidana penjara selama 3 (tiga) tahun dan denda sebesar Rp1.000.000.000,00 (satu miliar rupiah) apabila denda tersebut tidak dibayar maka diganti dengan pidana penjara selama 4 (empat) bulan. Putusan hakim yang sesuai dan menjerat pelaku agar tidak mengulangi perbuatannya tersebut dikemudian hari, dan membuat efek jera kepada pelaku.
TINJAUAN YURIDIS NON FUNGIBLE TOKEN (NFT) DARI ASPEK HUKUM BENDA DAN HAK KEKAYAAN INTELEKTUAL
Authors: Ziliwu Alfonsus Syukur Hadirat , Ndruru Utusama , Marbun Jaminuddin , Hamonangan Alusianto 
Published: April 2023

Hadirnya Industri 4.0 dan memasuki Society 5.0 memberikan kontribusi yang sangat besar terhadap lahirnya jenis aset baru, yaitu aset-aset yang berbasis digital. Tidak dapat dipungkiri bahwa semakin tingginya minat terhadap NFT. Transaksi NFT yang diperdagangkan secara internasional membuatnya semakin populer. Namun disisi lain, NFT juga sering digunakan oleh pihak ketiga untuk mengkomersialisasi karya seniman tanpa izin seniman tersebut. Seiring perkembangan NFT, ada banyak kegiatan yang berkaitan dengan transaksi NFT sehingga diperlukan adanya perangkat hukum yang dapat mengatur NFT. Maka dalam penelitian ini penulis inggin mengakji bagaimana pengaturan NFT dalam hukum positif Indonesia dengan judul : “Tinjauan Yuridis Non Fungible Token (NFT) Dari Aspek Hukum Benda Dan Hak Kekayaan Intelektual”.