bluuebunny/crossref_metadata_2025_split huggingface dataset:
2D Semiconducting Polymers Based on Aromatic 1,5‐Diheterocines with Oxygen and Nitrogen
Authors: Kevorkyants Ruslan 
Published: May 2023

AbstractA class of two‐dimensional polymers (2DP) based on aromatic oxygen‐ and nitrogen‐containing 1,5‐diheterocines is proposed. The diheterocines are interconnected via linkages with multiple bonds (─N═N─, ─C≡C─, ─N═CH─, ─CH═CH─) resulting in 30 polymers with 2D π‐conjugated network. According to DFT modeling nine of them are strictly planar species of monoclinic symmetry featuring either direct or indirect electronic transitions with HSE06 energies falling in the range [0.01–1.03] eV. The highest charge carrier velocity and corresponding lowest mass are estimated at 5.79 × 105 m s−1 and 9.45 × 10−3 m0, respectively. In addition to prospective optoelectronic applications, the polymers can be used in separation/filtration technologies. The proof‐of‐principle of N2/O2 separation is presented. Pore sizes of the 2DPs can be varied subject to the size of linkages. This study opens up new avenues for a design of multifunctional 2DPs.
KMT2D Deficiency Promotes Myeloid Leukemias which Is Vulnerable to Ribosome Biogenesis Inhibition
Authors: Xu Jing , Zhong Ailing , Zhang Shan , Chen Mei , Zhang Lanxin , Hang Xiaohang , Zheng Jianan , Wu Baohong , Deng Xintong , Pan Xiangyu , Wang Zhongwang , Qi Lu , Shi Kaidou , Li Shujun , Wang Yiyun , Wang Manli , Chen Xuelan , Zhang Qi , Liu Pengpeng , Gale Robert Peter , Chen Chong , Liu Yu , Niu Ting 
Published: May 2023

AbstractKMT2C and KMT2D are the most frequently mutated epigenetic genes in human cancers. While KMT2C is identified as a tumor suppressor in acute myeloid leukemia (AML), the role of KMT2D remains unclear in this disease, though its loss promotes B cell lymphoma and various solid cancers. Here, it is reported that KMT2D is downregulated or mutated in AML and its deficiency, through shRNA knockdown or CRISPR/Cas9 editing, accelerates leukemogenesis in mice. Hematopoietic stem and progenitor cells and AML cells with Kmt2d loss have significantly enhanced ribosome biogenesis and consistently, enlarged nucleolus, increased rRNA and protein synthesis rates. Mechanistically, it is found that KMT2D deficiency leads to the activation of the mTOR pathway in both mouse and human AML cells. Kmt2d directly regulates the expression of Ddit4, a negative regulator of the mTOR pathway. Consistent with the abnormal ribosome biogenesis, it is shown that CX‐5461, an inhibitor of RNA polymerase I, significantly restrains the growth of AML with Kmt2d loss in vivo and extends the survival of leukemic mice. These studies validate KMT2D as a de facto tumor suppressor in AML and reveal an unprecedented vulnerability to ribosome biogenesis inhibition.
Electric Field‐Assisted Uptake of Hexavalent Chromium Ions with In Situ Regeneration of Carbon Monolith Adsorbents
Authors: Wang Biao , Jiang Qi , Yang Guangxing , Wang Haofan , Wang Hongjuan , Peng Feng , Yu Hao , Huang Jiangnan , Zhong Guoyu , Cao Yonghai 
Published: May 2023

AbstractThe uptake of hexavalent chromium (Cr(VI)) ions from wastewater is of great significance for environmental remediation and resource utilization. In this study, a self‐designed instrument equipped with an oxidized mesoporous carbon monolith (o‐MCM) as an electro‐adsorbent is developed. o‐MCM with a super hydrophilic surface displayed a high specific surface area (up to 686.5 m2 g−1). With the assistance of an electric field (0.5 V), the removal capacity of Cr(VI) ions is as high as 126.6 mg g−1, much higher than that without an electric field (49.5 mg g−1). During this process, no reduction reaction of Cr(VI) to Cr(III) ions is observed. After adsorption, the reverse electrode with 10 V is used to efficiently desorb the ions on the carbon surface. Meanwhile, the in situ regeneration of carbon adsorbents can be obtained even after ten recycles. On this basis, the enrichment of Cr(VI) ions in a special solution is achieved with the assistance of an electric field. This work lays a foundation for the uptake of heavy metal ions from wastewater with the assistance of the electric field.
Dual cross‐linked self‐healing temperature and pressure sensor based on PAM/ENR/h‐BN composite
Authors: Ding Hongda , Wang Yanqiu , Shen Xiande 
Published: May 2023

AbstractSensor of monitor of temperature and pressure changes are garnering constant attention due to their wide applications. It is a challenge to synthesize dual‐functional material with the well‐balanced performance to temperature response and pressure changes. In this work, we have proposed a facile way to fabricate tough, flexible, and self‐healing composite with dually synergistic networks for pressure and temperature sensors, which are composed of polyacrylamide (PAM) and elastic epoxidized natural rubber (ENR). PAM networks are crosslinked by N,N‐methylenebisacrylamide (MBA) and physical crosslinking of hydrophilic hexagonal boron nitride (h‐BN) nanosheets, ENR network is further interlocked and PAM by physical entanglements, hydrogen bonds. It is found that the ternary PAM/ENR/h‐BN (PEB) composite is highly sensitive to temperature, making it can be exploited as a thermistor. This thermistor possesses high flexibility and appealing mechanical performance, with the sensitivity as high as 1.87%/°C at temperature range of −13 to 90°C. Furtherly, the PEB composite also can work as a flexible pressure sensor at operating range of ~80% strain and ~540 KPa. Our research work provides a guideline for the preparation of temperature monitor, piezoresistive pressure sensors, as well as flexible electronic products.
Investigation of sorption mechanisms of chemical contaminants in PHBV‐based food packaging material: Impact on closed‐loop mechanical recycling opportunities
Authors: Dedieu Isabelle , Aouf Chahinez , Gaucel Sébastien , Peyron Stéphane 
Published: May 2023

AbstractThe identification of contaminants on postconsumer food packaging is crucial for developing/adapting decontamination technology of closed‐loop mechanical recycling. So far, almost all contamination studies were conducted on PET bottles, with results extrapolated to other polymers. This work investigates the sorption mechanisms of three contaminants (Benzophenone, Ferulic acid and Irganox 1076), with different molecular weights and polarity, on the biodegradable polymer PHBV. Characterization of their respective partition coefficient (KP/L) and diffusion coefficient (D), under realistic conditions of use (contact with food simulants), allowed the modeling of their concentration profile in the thickness of the material. The results show a sorption in the core of PHBV of these three molecules, reached after a few hours/days. On the contrary, the same model applied to PET reveal a very slow sorption (several years), and only at the surface of the material. This study highlights the impact of polymer structure (chain mobility, polarity…) on contaminant sorption. The behavior of each polymer towards contaminants is directly related to its structure under given conditions of use, and it is a mistake to continue to address the decontamination processes of all polymers, based on the nature and level of contamination of PET.
Clinicopathological characteristics and survival outcomes in patients with angiosarcoma of breast
Authors: Li Junfeng , Li Yunhai , Wang Yuanyuan , Li Zhao , Zhang Huan , Gao Yidan , Tan Jinxiang 
Published: May 2023

AbstractBackgroundAngiosarcoma of the breast is a rare malignancy. There are little data evaluating the survival and estimating the prognostic factors. The best surgical management and the role of systemic adjuvant therapy remain ill‐defined. This study aimed to investigate the clinicopathological features, survival, and prognostic factors of breast angiosarcoma.MethodsThe data on patients diagnosed with breast angiosarcoma were extracted from the Surveillance, Epidemiology, and End Results database (1975–2016). Univariate and multivariate Cox regression analyses were used to estimate the influential prognostic factors. The overall survival (OS) and disease‐specific survival (DSS) of patients with breast angiosarcoma were evaluated.ResultsThis study included 656 patients diagnosed with breast angiosarcoma between 1975 and 2016. The 5‐year OS rate of all patients was 44.9% (95% CI 40.8–49.0). In both OS and DSS, Kaplan–Meier survival analyses revealed significant differences for both OS and DSS according to age, year at diagnosis, laterality, grade, and stage (all log‐rank p < 0.05). Multivariate analysis suggested that lesions of the right breast, poor differentiation, and advanced stage were independent risk factors for OS or DSS (all p < 0.05). Older age was a risk factor in OS, but was protective in DSS. In primary breast angiosarcoma, age, laterality, grade, and stage were independent prognostic factors in OS and DSS (all p < 0.05). Mastectomy was also a risk factor in DSS (p = 0.034). The proportion of patients with grade III and regional disease was larger in the mastectomy group.ConclusionAngiosarcoma of the breast had a poor prognosis. In our study, age, laterality, histologic grade, and stage were identified as significant prognostic factors. Why patients with angiosarcoma of the right breast had a worse prognosis remains equivocal. Mastectomy was adopted more often by surgeons in this cohort study for patients with advanced primary breast angiosarcoma.
Diagnosing, imaging, and successfully treating a debilitating case of Bing–Neel syndrome: A multidisciplinary feat
Authors: Kerley Robert N. , O'Donnell Niamh , Lynott Fiona , Mulcahy Riona , Hennessy Brian 
Published: May 2023

Key Clinical MessageWe present a case of Bing–Neel syndrome a rare central nervous system lymphoplasmocytic lymphoma associated with Waldenstrom macroglobulinemia. Diagnosis should be considered in the context of unexplained neurological symptoms in the presence of macroglobulinemia.AbstractWaldenstroms macroglobulinaemia (WM) is a rare B‐cell lymphoma representing ~2% of all hematological malignancies. While most neurological complications of WM are secondary to the overproduction of immunoglobulin M (IgM), Bing‐Neel syndrome (BNS) is an extremely rare direct central nervous system (CNS) infiltration by malignant lymphoplasmocytic lymphoma (LPL) cells. Limited information on BNS exists in the literature with sparse case reports and case series. Here, we present a diagnostically challenging BNS case successfully treated with systemic chemoimmunotherapy and ibrutinib, with remarkable clinical response.
Visceral leishmaniasis complicated by hemophagocytic lymphohistiocytosis: A case report from a nonendemic area
Authors: Joudeh Anwar I. , Elsiddig Awadelkarim Hussein A. , Gul Mohammadshah Isam , Elayana Mahmoud Salm , Soliman Dina Sameh , Amer Aliaa , Alsamawi Musaed 
Published: May 2023

Key Clinical MessageVisceral leishmaniasis and hemophagocytic lymphohistiocytosis share many features in common and may coincide in the same patient. Timely diagnosis and management of visceral leishmaniasis could save patients from unnecessary toxic treatment.AbstractVisceral leishmaniasis and hemophagocytic lymphohistiocytosis share many clinical features in common and may coexist in the same patient. Visceral leishmaniasis should be promptly ruled out in patients coming from endemic areas before starting immunosuppressive therapy for hemophagocytic lymphohistiocytosis. The mainstay treatment, in this case, is anti‐leishmania medications preferably liposomal amphotericin‐B.
Bilateral pulmonary embolism associated with peripheral blood eosinophilia and positive antiphospholipid antibodies in a patient with cellulitis
Authors: Tun Han Naung , Kyaw May Thu , Chernikova Daryna , Trofenciuc Mihai , Raza Syed Haseeb , Abdelnabi Mahmoud 
Published: May 2023

Key Clinical MessageThis report described the pathophysiology, diagnostic workup, and management of thrombosis possibly associated with peripheral blood eosinophilia and transient positive antiphospholipid antibodies in the setting of cellulitis.AbstractPeripheral blood eosinophilia is a risk factor for thrombosis and the presence of other prothrombotic factors such as antiphospholipid antibodies can potentiate that risk. The authors present a case of acute pulmonary embolism which developed at the peak of eosinophilia, later found to have transient positive antiphospholipid antibodies in a male patient with right lower limb cellulitis and a history of intravenous drug abuse. This report illustrates the pathophysiology, diagnosis workup, and therapeutic options of thrombosis possibly associated with peripheral blood eosinophilia and positive antiphospholipid antibodies, which include anticoagulants, corticosteroids, and immunosuppressants. Clinicians should be aware of this possible association which may guide the choice and duration of anticoagulants. Although direct oral anticoagulants are effective anticoagulants in various thromboembolic events, studies showed unfavorable outcomes for their use in antiphospholipid syndrome.
Glycogen storage disease in two sisters: A case report
Authors: Twanabasu Sajal , Duwadee Prabin , Homagain Sushan , Ghimire Jeevan , Rijal Ram Chandra 
Published: May 2023

Key Clinical MessageGlycogen storage diseases (GSDs) are rare autosomal disorders that result from defects in glycogen metabolism. There are more than 12 types, each with distinct clinical features. Clinical scenario, biochemical abnormalities are useful for suspicion whereas liver biopsy and enzyme assay provides definite diagnosis. We report a case of two sisters with similar clinical symptoms suggestive of the disease.
A “solid” solution for wheat stem sawfly (Hymenoptera: Cephidae) resistance: Genetics, breeding and development of solid stem wheat
Authors: Bathini Akshara , Mendu Lavanya , Singh Nagendra Pratap , Cook Jason , Weaver David , Sherman Jamie , Hager Megan , Mondal Suchismita , Mendu Venugopal 
Published: May 2023

AbstractWheat (Triticum spp. L) production needs to be improved to meet the needs of a global population of >9 billion people by 2050. Increasing the productivity of the crop under conditions of abiotic and biotic stress to achieve food security continues to be a challenging proposition. Wheat stem sawfly (WSS) (Cephus cinctus Norton) has been considered as a serious pest of wheat since the late 19th century, causing devastating losses of wheat productivity in the Northern Great Plains of United States and regions of Canada. Developing resistant varieties of wheat that show consistent agronomic performances in varying environments is an effective strategy to manage WSS infestations. To achieve this goal, it is necessary to understand the underlying mechanisms of WSS infestation, damage, subsequent response of the host plant, and resulting yield losses. The review focuses on genetics, breeding, and development of solid stem (SS)‐mediated WSS resistance in wheat since it has been the most effective method of genetic resistance in reducing wheat yield losses. Furthermore, the knowledge gaps that need to be addressed to develop an effective resistant cultivar against WSS are also discussed.
An isolated high‐gain impedance source‐based single‐phase AC–AC converter with safe commutation and variable output frequency
Authors: Abdoli Iman , Mosallanejad Ali 
Published: May 2023

SummaryConventional AC–AC converters have some critical disadvantages, such as inappropriate input and output power quality features, employing snubber circuits to suppress the voltage stress on high‐frequency switches without a safe commutation method that increases the converter size and cost, confined voltage gain, and using huge passive components. This paper proposes an isolated high‐gain single‐phase AC–AC converter with variable output frequency, extended voltage gain, and a safe commutation strategy. Ten semiconductors are only employed for the proposed topology that only two switches and two diodes are operated with high‐frequency PWM signals. This new topology has noteworthy specifications like continuous input and output current, voltage isolation, extended inverting and non‐inverting buck‐boost modes, and frequency regulation. The high voltage gain has been achieved with small values for passive components in the impedance source section, reducing the volume and cost of the converter. The impedance source‐based section of the converter comprises one input inductor, two coupled inductors, and two capacitors in each converter leg. A safe commutation strategy has been designed and applied to the converter to mitigate the voltage and current stresses without extra snubber circuits. The number of semiconductors that simultaneously conduct in each state of the converter has been reduced. So, the conduction loss of the converter diminished. The achieved efficiency equals 95.5% and 93.5% in step‐down and step‐up modes, respectively, validated by an accurate power loss model and experimental analysis. An experimental prototype has been designed to confirm the performance of the suggested converter. Results confirm the theory and operation of the proposed converter.
An efficient FPGA‐based implementation of UWB radar system for through‐wall imaging
Authors: Saad Mohamed , Maali Abdelmadjid , Salah Azzaz Mohamed , Benssalah Mustapha 
Published: May 2023

SummaryThe work presented in this paper aims to develop a low‐cost ultra‐wideband (UWB) radar system that has the capability to image through the wall of a human target. The proposed radar system relies heavily on a field‐programmable gate array (FPGA) platform. The Xilinx FPGA Kintex‐7 (KC705) board is employed to integrate the main functionalities of the radar system, such as the generation and acquisition of a UWB signal. The generated signal is a monocycle signal, which has an ultra‐wide bandwidth. Due to the UWB nature of this signal, the radar system achieves better penetration ability, as well as high imaging resolution. However, the major challenge of a UWB radar system lies in the stage of digitization, as it requires a high sampling rate analog‐to‐digital converter (ADC). In fact, such a chip is very expensive. Hence, to reach a high sampling resolution using a low‐cost and low‐speed ADC, an efficient sampling strategy is implemented. In contrast to other UWB sampling methods, which require a hardware delay line chip, the new sampling scheme depends only on the FPGA firmware to realize a combination of real‐time and equivalent‐time sampling, which provides better jitter performance. Finally, to demonstrate the imaging capability, experimental tests are conducted in an indoor environment while human targets are located in different places. The measurement results revealed that the proposed radar system has the ability to provide 2D images that accurately determine the location of the target.
Functional, antioxidant, and sensory properties of mixed‐fruit (pitaya, watermelon, and mint) and pitaya wines
Authors: Hu Tsung‐Ming , Gavahian Mohsen , Pradhan Rojina , Lu Si‐Yu , Chu Yung‐Lin 
Published: May 2023

AbstractFermentation of fruits offers a diverse range of flavors, smells, and colors. Colored fruits are rich in naturally occurring pigments, such as betacyanin. Hence, they are considered to possess powerful antioxidant activities. However, in wine production, such pigments often diversify the flavor and color of the wine. The objective of this study was to compare the quality of two types of wines: a single‐fruit (pitaya) wine and a mixed‐fruit wine that contains watermelon (Citrullus lanatus), mint (Mintha spicata), and pitaya (Hylocereus costaricensis). In this study, fresh pitaya, watermelon, and mint leaves were fermented using Saccharomyces cerevisiae. Juice extracts underwent fermentation at room temperature for 7 days under dark conditions. Physicochemical changes, such as pH, sugar content, specific gravity, and alcohol content, were observed daily. The antioxidant activities were measured by the 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH) assay, the ferric reducing antioxidant power (FRAP) assay, and total phenolic contents (TPCs). After 14 days of fermentation, the alcohol contents of mixed and pitaya wine were 11.22% (v/v) and 11.25%, respectively. The total sugar content of the mixed wine was 8.0 °Brix, while that of pitaya wine was 7.0 °Brix. Moreover, pitaya wine exhibited a higher TPC (22.7 mg GAE/100 g D.W.), and better FRAP (3578 μmole/L) and DPPH scavenging ability (80.2%) compared to the mixed wine with a TPC of 21.4 mg GAE/100 g D.W., FRAP of 2528 μmole/L, and DPPH of 75.6%., while the addition of watermelon and mint did not change the alcohol percentage contents of wine.
Wnt/β‐catenin signaling pathway inhibitors, glycyrrhizic acid, solanine, polyphyllin I, crocin, hypericin, tubeimoside‐1, diosmin, and rutin in medicinal plants have better binding affinities and anticancer properties: Molecular docking and ADMET study
Authors: Egbuna Chukwuebuka , Patrick‐Iwuanyanwu Kingsley C. , Onyeike Eugene N. , Uche Chukwuemelie Zedech , Ogoke Uchenna Petronilla , Riaz Muhammad , Ibezim Ebube Nnamdi , Khan Johra , Adedokun Kamoru A. , Imodoye Sikiru O. , Bello Ibrahim O. , Awuchi Chinaza Godswill 
Published: May 2023

AbstractWnt/β‐catenin signaling pathway plays a role in cancer development, organogenesis, and embryogenesis. The abnormal activation promotes cancer stem cell renewal, proliferation, and differentiation. In the present study, molecular docking simulation and ADMET studies were carried out on selected bioactive compounds in search of β‐catenin protein inhibitors for drug discovery against cancer. Blind docking simulation was performed using PyRx software on Autodock Vina. β‐catenin protein (PDB ID: 1jdh) and 313 bioactive compounds (from PubChem database) with selected standard anticancer drugs were used for molecular docking. The ADMET properties of the best‐performing compounds were calculated using SwissADME and pkCMS web servers. The results obtained from the molecular docking study showed that glycyrrhizic acid, solanine, polyphyllin I, crocin, hypericin, tubeimoside‐1, diosmin, and rutin had the best binding interactions with β‐catenin protein based on their binding affinities. Glycyrrhizic acid and solanine had the same and lowest binding energy of −8.5 kcal/mol. This was followed by polyphyllin I with −8.4 kcal/mol, and crocin, hypericin, and tubeimoside‐1 which all had a binding energy of 8.1 kcal/mol. Other top‐performing compounds include diosmin and rutin with binding energy of −8.0 kcal/mol. The ADMET study revealed that the following compounds glycyrrhizic acid, solanine, polyphyllin I, crocin, hypericin, tubeimoside‐1, diosmin, rutin, and baicalin all violated Lipinski's rule of 5 which implies poor oral bioavailability. However, based on the binding energy score, it was suggested that these pharmacologically active compounds are potential molecules to be tested against cancer.
Similar somatotopy for active and passive digit representation in primary somatosensory cortex
Authors: Sanders Zeena‐Britt , Dempsey‐Jones Harriet , Wesselink Daan B. , Edmondson Laura R. , Puckett Alexander M. , Saal Hannes P. , Makin Tamar R. 
Published: May 2023

AbstractScientists traditionally use passive stimulation to examine the organisation of primary somatosensory cortex (SI). However, given the close, bidirectional relationship between the somatosensory and motor systems, active paradigms involving free movement may uncover alternative SI representational motifs. Here, we used 7 Tesla functional magnetic resonance imaging to compare hallmark features of SI digit representation between active and passive tasks which were unmatched on task or stimulus properties. The spatial location of digit maps, somatotopic organisation, and inter‐digit representational structure were largely consistent between tasks, indicating representational consistency. We also observed some task differences. The active task produced higher univariate activity and multivariate representational information content (inter‐digit distances). The passive task showed a trend towards greater selectivity for digits versus their neighbours. Our findings highlight that, while the gross features of SI functional organisation are task invariant, it is important to also consider motor contributions to digit representation.