bluuebunny/crossref_metadata_2025_split huggingface dataset:
The quality and clinical translation of radiomics studies based on MRI for predicting Ki-67 levels in patients with breast cancer
Authors: Wang Min , Mei Ting , Gong Youling 
Published: September 2023

Objective:
To evaluate the methodological quality of radiomics literature predicting Ki-67 levels based on MRI in patients with breast cancer (BC) and to propose suggestions for clinical translation.

Methods:
In this review, we searched PubMed, Embase, and Web of Science for studies published on radiomics in patients with BC. We evaluated the methodological quality of the studies using the Radiomics Quality Score (RQS). The Cochrane Collaboration’s software (RevMan 5.4), Meta-DiSc (v. 1.4) and IBM SPSS (v. 26.0) were used for all statistical analyses.

Results:
Eighteen studies met our inclusion criteria, and the average RQS was 10.17 (standard deviation [SD]: 3.54). None of these studies incorporated any of the following items: a phantom study on all scanners, cut-off analyses, prospective study, cost-effectiveness analysis, or open science and data. In the meta-analysis, it showed apparent diffusion coefficient (ADC) played a better role to predict Ki-67 level than dynamic contrast-enhanced (DCE) MRI in the radiomics, with the pooled area under the curve (AUC) of 0.969.

Conclusion:
Ki-67 index is a common tumor biomarker with high clinical value. Radiomics is an ever-growing quantitative data-mining method helping predict tumor biomarkers from medical images. However, the quality of the reviewed studies evaluated by the RQS was not so satisfactory and there are ample opportunities for improvement. Open science and data, external validation, phantom study, publicly open radiomics database and standardization in the radiomics practice are what researchers should pay more attention to in the future.

Advances in knowledge:
The RQS tool considered the radiomics used to predict the Ki-67 level was of poor quality. ADC performed better than DCE in radiomic prediction. We propose some measures to facilitate the clinical translation of radiomics.
Why Fixed Costs Matter for Proof-of-Work–Based Cryptocurrencies
Authors: Garratt Rodney J. , van Oordt Maarten R. C. 
Published: September 2023

We assess how the cost structure of cryptocurrency mining affects the response of miners to exchange rate fluctuations and the immutability of cryptocurrency ledgers that rely on proof-of-work. We show that the amount of mining power supplied to currencies that rely on specialized hardware, such as Bitcoin, responds less to adverse exchange rate shocks than other currencies respond to such shocks, a fact that is instrumental to avoiding double-spending attacks. The results may change if mining equipment used for one cryptocurrency can be transferred to another. For smaller currencies with low exchange rate correlation, transferability eliminates the protection that fixed costs provide. Our results weaken doomsday predictions for Bitcoin and other cryptocurrencies with declining block rewards. This paper was accepted by Bruno Biais, Special Section of Management Science: Blockchains and Crypto Economics. Supplemental Material: The data files are available at https://doi.org/10.1287/mnsc.2023.4901 .
Pick-an-Object Mechanisms
Authors: Bó Inácio , Hakimov Rustamdjan 
Published: September 2023

We introduce a new family of mechanisms for one-sided matching markets, denoted pick-an-object (PAO) mechanisms. When implementing an allocation rule via PAO, agents are asked to pick an object from individualized menus. These choices may be rejected later on, and these agents are presented with new menus. When the procedure ends, agents are assigned the last object they picked. We characterize the allocation rules that can be sequentialized by PAO mechanisms and the ones that can be implemented in a robust truthful equilibrium. We justify the use of PAO as opposed to direct mechanisms by showing that its equilibrium behavior is closely related to the one in obviously strategy-proof (OSP) mechanisms, but implements commonly used rules, such as Gale-Shapley DA and top trading cycles, which are not OSP implementable. We run laboratory experiments comparing truthful behavior when using PAO, OSP, and direct mechanisms to implement different rules. These indicate that agents are more likely to behave in line with the theoretical prediction under PAO and OSP implementations than their direct counterparts. This paper was accepted by Yan Chen, behavioral economics and decision analysis. Funding: This research is funded by the National Natural Science Foundation of China [Grant 72033006]. R. Hakimov was supported by the Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung [Project 100018_189152]. Supplemental Material: The data files are available at https://doi.org/10.1287/mnsc.2023.4908 .
Text-Based Measure of Supply Chain Risk Exposure
Authors: Wu Di (Andrew) 
Published: September 2023

Using textual analysis techniques, including seeded word embedding and bag-of-words-based content analysis, I develop a firm-level measure of supply chain risk exposure from a novel source of unstructured data—the discussion between managers and equity analysts on supply chain-related topics during firms’ quarterly earnings conference calls. I validate the measure by showing that (1) the measure exhibits intuitive variations over time and across firms, successfully capturing both routine and systematic supply chain risk events; and (2) the measure is about risk exposure, as it significantly correlates with realized and options-implied stock return volatility, even after controlling for well-known aggregate risk measures. I then demonstrate that the measure is specifically indicative of the supply chain component of risk exposure. (3) Consistent with theoretical predictions, firms facing higher supply chain risks have higher inventory buffers, particularly in raw materials and intermediate inputs, increased cash holdings in lieu of investments, and significantly lower trade credit received from suppliers. Moreover, (4) during unexpected risk episodes, such as the Tohoku earthquake, firms with higher ex ante risk exposure have worse operating and financial performance. These results indicate that the text-based measure provides a credible quantification of firm-level exposure to supply chain risks and can thus be reliably utilized as outcome or explanatory variables in empirical supply chain research. This paper was accepted by Jeannette Song, operations management. Supplemental Material: The data files and online appendix are available at https://doi.org/10.1287/mnsc.2023.4927 .
We Can Be the New Wind, Alexandros Anesiadis (2022)
Authors: Bestley Russ 
Published: September 2023

Review of: We Can Be the New Wind, Alexandros Anesiadis (2022)
Ticehurst: Earth Island Books, 822 pp.,
ISBN 978-1-83835-676-7, p/bk, £29.99

A Hardcore Heart: Adventures in a DIY Scene, David Gamage (2022)
Ticehurst: Earth Island Books, 654 pp.,
ISBN 978-1-73964-773-5, p/bk, £24.99
Extracellular fibrin promotes non-small cell lung cancer progression through integrin β1/PTEN/AKT signaling
Authors: Li Guilong , Cai Jiaying , Xie Jianjun , Dai Yizhi 
Published: September 2023

Abstract
The extracellular matrix (ECM) has been strongly correlated with cancer progression in various tumor types. However, the specific mechanisms underlying ECM-associated tumor behaviors remain unclear. In this study, we found an enriched distribution of fibrin in tumor tissues obtained from high-grade non-small cell lung cancer (NSCLC) patients. For further investigation, we established an in vitro 3D culture system using fibrin gel and found that NSCLC cells grown in this system exhibited increased stemness and tumorigenesis. Mechanistically, we demonstrated that fibrin facilitated the activation of the phosphatase and tensin homolog (PTEN)/protein kinase B (AKT) signaling pathway through integrin β1. Furthermore, we found that blocking integrin β1 signals enhanced the tumor suppressive effects of chemotherapy, providing a novel approach for clinical therapy for NSCLC.
Evaluation of second trimester plasma lipoxin A4, VEGFR-1, IL-6, and TNF-α levels in pregnant women with gestational diabetes mellitus
Authors: Kiran Tugba Raika , Melekoglu Rauf , Otlu Onder , Inceoglu Feyza , Karabulut Ercan , Erenler Ayse Sebnem 
Published: September 2023

Abstract
In this study, our objective was to explore the association between gestational diabetes mellitus (GDM) and second trimester maternal plasma levels of lipoxin A4 (LXA4), along with proinflammatory markers such as interleukin-6 (IL-6) and tumour necrosis factor alpha (TNF-α), and the anti-angiogenic factor vascular endothelial growth factor receptor 1 (VEGFR-1) in pregnant women. The study included a cohort of 30 pregnant women with GDM and a control group of 30 normoglycaemic pregnant women matched for age, body mass index, and gestational age. Plasma samples were collected and analysed by enzyme-linked immunosorbent assay to assess specific biomarkers. The GDM group had significantly lower levels of LXA4 and higher levels of TNF-α and VEGFR-1 compared to the control group (p = 0.038, p = 0.025, and p = 0.002, respectively). A statistically significant decrease in the LXA4/TNF-α ratio was observed in the GDM group (p = 0.004). The results suggest that each unit decrease in the LXA4/TNF-α ratio is associated with a 1.280-fold increase in the risk of GDM. These findings suggest a potential diagnostic role for the LXA4/TNFα ratio as a marker for women with GDM. This work provides new insights into the pathogenesis of GDM and highlights the important interplay between inflammation and metabolic dysregulation.
Beyond learning opportunities: focused encounters in a sociocognitive approach to second language acquisition and teaching
Authors: Atkinson Dwight , Burhan-Horasanlı Elif , Sagre Barboza Anamaría , Mejía-Laguna Jorge Andres , Oguilve Verónica , Ribeiro Amable Daiane Custodio 
Published: September 2023

Abstract
This paper introduces the sociological concept of focused encounters (FEs) as a tool for researching interaction in second language acquisition and teaching. FEs are face-to-face interactions affording joint attention, intersubjectivity, interaffectivity, and interactional alignment, considered key contributors to learning in some SLA/T approaches. First, we introduce the FE concept. Second, we situate FEs within a sociocognitive approach to SLA/T. Third, we apply the FE concept in investigating interaction in an Australian English as a second language classroom. Fourth and finally, we discuss our analysis’s wider implications for learning and teaching: Studying interaction in FEs from a sociocognitive perspective enables investigation not just of language learning opportunities but of moment-by-moment learning processes.
Tax Policy Implemented in Mongolia by the Manchus
Authors: Dorjpalam Oyuntsetseg , Selenge Tuul , Gotov Otgonsuren 
Published: September 2023

Abstract
After the new Manchuria state established in 1916 annexed China, Khalkh carried out a policy of conquering Mongolia from 1644 to 1691, conquering Upper Mongolia in 1691 and Western Mongolia in 1755. During the time when the Manchus kept the Mongols under their oppression from the XYII-early XX century, they collected more than 20 types of services and tributes from the Mongols, in addition to imposing the Nine White Service, they collected the necessary expenses for the Manchurian administration and temples, and sent Mongolian citizens to horse stations, expenses, and communication offices. The office was closed. During the period under Manchurian oppression, the economy and livelihood of the Mongols became unbearable, so they were able to gain independence in 1911 through a rebellion and struggle.
The crystal structure of 5-chloro-6′-methyl-3-(4-(methylsulfonyl)phenyl)-[2,3′-bipyridin]-1′-ium 4-methylbenzenesulfonate
Authors: Fang Yu , Zhang Cheng , Yin Meng-Qing , Yang Xiao-Die , Ma Wen-Jing 
Published: September 2023

Abstract
C18H16ClN2O2S·C7H7O3S, monoclinic, C2/c (no. 15), a = 36.911(9) Å, b = 9.931(2) Å, c = 14.795(3) Å, β = 112.32(3)°, V = 5017(2) Å3, Z = 8, R

gt
(F) = 0.0500, wR

ref
(F
2) = 0.1447, T = 293 K.
Influence of surfactant concentration on selected quality parameters of fruit washing agents
Authors: Hordyjewicz-Baran Zofia , Wasilewski Tomasz , Zarębska Magdalena , Seweryn Artur 
Published: September 2023

Abstract
In this study, special types of washing agents, intended for fruit washing were developed. Fruit washing agents with different contents of non-ionic surfactants have been prepared. The developed products were characterized in terms of performance with regard to their ability to remove pesticide residues from fruit surfaces. Special attention was paid to the safety of use in relation to the level of skin irritation during washing. The results provided important information on the effect of surfactant concentration on selected quality parameters of the developed fruit washing agents.
PRMT inhibitor promotes SMN2 exon 7 inclusion and synergizes with nusinersen to rescue SMA mice
Authors: Kordala Anna J , Stoodley Jessica , Ahlskog Nina , Hanifi Muhammad , Garcia Guerra Antonio , Bhomra Amarjit , Lim Wooi Fang , Murray Lyndsay M , Talbot Kevin , Hammond Suzan M , Wood Matthew JA , Rinaldi Carlo 
Published: September 2023

AbstractSpinal muscular atrophy (SMA) is a leading genetic cause of infant mortality. The advent of approved treatments for this devastating condition has significantly changed SMA patients' life expectancy and quality of life. Nevertheless, these are not without limitations, and research efforts are underway to develop new approaches for improved and long‐lasting benefits for patients. Protein arginine methyltransferases (PRMTs) are emerging as druggable epigenetic targets, with several small‐molecule PRMT inhibitors already in clinical trials. From a screen of epigenetic molecules, we have identified MS023, a potent and selective type I PRMT inhibitor able to promote SMN2 exon 7 inclusion in preclinical SMA models. Treatment of SMA mice with MS023 results in amelioration of the disease phenotype, with strong synergistic amplification of the positive effect when delivered in combination with the antisense oligonucleotide nusinersen. Moreover, transcriptomic analysis revealed that MS023 treatment has minimal off‐target effects, and the added benefit is mainly due to targeting neuroinflammation. Our study warrants further clinical investigation of PRMT inhibition both as a stand‐alone and add‐on therapy for SMA.
The Phase Еquilibrium in the HgS–Ga2S3–Bi(Sb)2S3 Systems
Authors: Smitiukh O.V. , Petrus’ I.I. 
Published: September 2023

Phase equilibria in the quasi-ternary systems HgS–Ga2S3–Bi(Sb)2S3 were studied by physico-chemical analysis methods on 177 alloys that were synthesized by direct single-temperature method. Phase diagrams of the quasi-binary systems HgS–Bi2S3 and Ga2S3–Bi2S3, six vertical sections (HgGa2S4–HgBi2S4, HgGa2S4–Bi2S3, HgGa6S10–Bi2S3, HgGa6S10–HgBi2S4, HgGa2S4–Sb2S3, and HgS–“GaSbS3”), and liquidus surface projections were investigated. Due to large primary crystallization region of mercury thiogallate, particularly at the HgGa2S4–Bi2S3 and HgGa2S4–HgBi2S4 sections, and low temperature (950-1050 K), the growth of single crystals of mercury thiogallate is possible using solution-melt method.
Self-perception and self-recognition while looking in the mirror on psilocybin
Authors: Elias Sam , Spivak Stephanie , Alverez Alexa , Gili Olivares Alejandro , Ferrol Maria , Keenan Julian Paul 
Published: September 2023

AbstractIntroductionIt is not known how self-perception and self-recognition are influenced when one is highly self-focused under the influence of psilocybin. Here we examine self-reports of mirror self-recognition and self-perception during a psilocybin experience.MethodsReddit posts were examined in a systematic manner. Posts that were written by individuals that ingested psilocybin and subsequently looked in a mirror were examined. After both automatic and manual filtering, a total of 89 posts with 775 post excerpts were analyzed.ResultsIt was found that it was rare to see one's own face as a different entity (e.g., an animal or other person) however people were equally likely to see themselves as they really are or distorted. People were significantly more positive than negative when perceiving their own face.DiscussionWe found wide variation in the perception of the own-face while under the influence of psilocybin. While generally positive, the self-face appears to be an experience that varies dramatically from person to person under the influence of psilocybin.
Prospective observation study of the effect of dupilumab on the body weight of children with atopic dermatitis
Authors: Zaslavsky Denis V. , Taganov Alexey V. , Bolshakova Elena S. , Manylova Elena S. , Kozlova Daria V. 
Published: September 2023

BACKGROUND: Dupilumab is a drug from the group of biological therapy approved for use in children from 6 years of age in Russian Federation. Due to the recent introduction into clinical practice, appear new reports about various clinical effects that may be associated with the use of the drug, but are not listed in the instructions. Thus, cases of the possible effect of dupilumab on weight gain in adult patients with atopic dermatitis have been reported. We recorded a weight change greater than the average weight gain in children treated with dupilumab.
AIM: The aim of the study was to evaluate the change in the weight of patients with moderate to severe atopic dermatitis treated with dupilumab for a year.
MATERIALS AND METHODS: From January to December 2022 28 children with moderate and severe atopic dermatitis were under observation. All patients were treated with dupilumab in accordance with clinical guidelines for the treatment of atopic dermatitis. Before and at the end of the study, patients were assessed for the severity of the disease, height, body weight, the body mass index, as well as a survey about the quality of sleep and compliance with a hypoallergenic diet. Patients were divided into 2 age groups: 610 years old and 1113 years old. The results of measurements were evaluated separately in each age group and were correlated with centile tables.
RESULTS: The study included 28 patients aged 6 to 13 years [18 girls (64.3%) and 10 boys (35.7%), mean age 10.25 years] with moderate (n = 11; 39.3%) and severe (n = 17; 60.7%) course of atopic dermatitis (mean SCORAD 57.3 4.6). At the end of the observation period, weight gain in the first age group was 5.8 kg; in the second group 3.06 kg; while the body mass index increased in the first age group by 1.65; in the second group by 0.23. According to the results of the survey at the initiation stage 19 (67.86%) participants in the observational program noted the presence of sleep disorders, 17 (60.71%) patients followed a hypoallergenic diet. At the end of the observation period 15/19 (78.94%) patients noted an improvement in the quality of sleep, 12/17 (70.59%) patients indicated an increase in the diet.
CONCLUSIONS: The first data on a probable association between the treatment of atopic dermatitis with dupilumab and weight gain in the pediatric population are presented. The exact mechanism of the drug effect on weight gain is not clear, but the positive effect is to expand the diet, normalize sleep and improve the psychological background, which leads to an increase in body weight in relation to its initial shortage.
Evaluating Community-Engaged Research in Promotion and Tenure
Authors: Wendling Lauren 
Published: September 2023

To advance and encourage partnerships between institutions and their greater communities, academic reward structures must be designed in ways that support those who choose to leverage their expertise, resources, and time to engage with community in meaningful and mutually beneficial ways. This study investigates how school- and department-level promotion and tenure committees define, understand, and evaluate faculty’s engaged research. Specifically, this study explored what goes into making evaluative decisions and how evaluative decisions are made (e.g., how review committees define and categorize faculty’s engaged research, what metrics are used to assess it). In this single case multi-site qualitative study 12 participants across five R1 institutions classified as engaged by the Carnegie Foundation participated in semi-structured interviews. All participants were tenured, engaged scholars with experience serving on a school- and/or department-level promotion and tenure review committee. Findings demonstrate that review committees struggle to define, categorize, and evaluate community engaged research in promotion and tenure, as they are forced to exclusively rely on a traditional set of metrics to evaluate the engaged work of their peers. Though universities are making strides to institutionalize engagement, appropriate recognition of engaged research within promotion and tenure is not yet a reality.
Digital ethics in education: An examination of Omani information studies students’ ethical competencies during e-learning
Authors: Shehata Ahmed , Khalaf Mustafa Ali , Al-Hijji Khalfan , Osman Nour Eldin 
Published: September 2023

Shifting to an e-learning style forced students to learn many skills and competencies to benefit from their experience in an e-learning environment. Ethical competencies play a crucial role in ensuring the fairness of students' assessments and the overall educational process. During the COVID-19 pandemic, the research used a questionnaire to evaluate the ethical understanding of students enrolled in Sultan Qaboos University's Information Studies Department using a quantitative methodology. The findings of this study reveal a significant lack of basic ethical competencies among students in the e-learning environment which negatively impacts their educational experience. The responses obtained indicate a low level of awareness regarding ethical practices in e-learning as well as a lack of knowledge concerning learning misconduct practices. The study suggests the implementation of an educational program that addresses academic ethical practices and e-learning misconduct across all educational levels. The outcomes of this research contribute to a better understanding of current e-learning practices among students, raise awareness about the importance of ethical competencies in e-learning and provide guidance for students to develop ethical digital competencies.
UJI PENGARUH PESTISIDA NABATI MENGGUNAKAN EKSTRAK DAUN MIMBA (Azadirachta indica) DAN UMBI GADUNG (Dioscorea hispida Dennst.) TERHADAP WALANG SANGIT PADA TANAMAN PADI
Authors: Noor Ilmah , Sari Sasi Gendro , Faulina Faulina 
Published: September 2023

Vegetable pesticides are pesticides whose basic ingredients come from plants. The plants that can be used as vegetable pesticides are neem (Azadirachte indica) and Gadung (Dioscorea hispida Dennst.) plants which contain active ingredients that can control insect pests. Neem leaves contain active ingredients in the form of azadirachtin, meliantriol, salanin, and nimbin. Meanwhile, gadung tubers are known to contain toxic active compounds, namely dioscorin, diosgenin, dioscin, saponins, alkaloids, and phenols. The purpose of this study was to determine the effectiveness of the effect of botanical pesticides using extracts of neem leaves and Gadung tubers against rice pests, namely Walang Sangit (Leptocorisa oratorius F.). The method of application to Walang Sangit was carried out with different concentrations, namely 40 ml/L, 60 ml/L, and 80 ml/L. The time of application of the extract was carried out in 3 treatments, namely in the morning (08.00 – 10.00 WITA), in the afternoon (11.00 – 12.00 WITA), and in the afternoon (16.00 – 18.00 WITA). The test results were seen 24 hours after the application of the extract. The results showed that the concentration that had the best results was at a concentration of 40 ml/liter which was able to kill or kill stink bugs with a period of 48-50 hours. This can be used as an alternative or one of the recommendations in controlling insect pests, especially for walang sangit.