bluuebunny/crossref_metadata_2025_split huggingface dataset:
S-9-PAHSA regulates glycolipid metabolism by enhancing autophagy and upregulating PI3K/AKT pathway
Authors: Yu Zhong-yu , Lin Jin-hong , Wang Jian-tao , Liu Ying-chao , Zhang Xiao-ming , Wen Xiao-hong , Zhang Qian , Xu Xiao-die , He Cheng-feng , Xue Wen-jiao , Wang Xin-ru , Ren Jiao-qi , Wang Jin-xiu , Wang Yin , Xiao Ji-chang , Guo Jing-chun , Zhou Hou-guang 
Published: August 2023

Abstract
The disorders of glucolipid metabolism are prevalent in patients with type 2 diabetes
mellitus (T2DM). Since the effects of Palmitic-Acid-Hydroxy-Stearic Acid (PAHSA)
on T2DM were not fully understood, the study aimed to investigate the role of S-9-
PAHSA in diabetes and the possible mechanisms. Male C57BL6 mice were fed with a
high-fat diet (HFD) and injected with streptozotocin (STZ) to establish the diabetic
mice model, and then administered with low- or high-dose S-9-PAHSA. Insulin,
glycosylated serum protein (GSP), glucagon-like peptide-1 (GLP-1), and oxidized lowdensity
lipoprotein (ox-LDL) were assessed by ELISA. SH-SY 5Y cells were incubated
in a diabetic environment and treated with S-9-PAHSA, R-9-PAHSA, or 9-PAHSA.
Cell viability, cell proliferation, apoptosis, lactate dehydrogenase (LDH), and reactive
oxygen species (ROS) were measured by corresponding kits. Protein expressions were
determined by western blot. The results showed high-does S-9-PAHSA improved
insulin resistance and lowered ox-LDL. Compared with the control group, the
significantly up-regulated expression of p62 and down-regulated expression of beclin
1 were found in diabetic mice and could be reversed by S-9-PAHSA. In vitro, S-9-
PAHSA increased cell viability and proliferation while reducing LDH and ROS. S-9-
PAHSA could reduce the expression of cleaved caspase-3 and TUNEL-positive cells,
and increase the ratio of LC3II/I after high glucose and fatty acid stimulation in vitro.
Downward trends were observed in PI3K and the phosphorylation of AKT in diabetic
environments, which could be slightly restored by S-9-PAHSA. In conclusion, S-9-
PAHSA could regulate glycolipid metabolism both in vivo and in vitro, indicating the
vital role of S-9-PAHSA in T2DM.
RCTrep: An R Package for the Validation of Estimates of the Average Treatment Effect
Authors: Shen Lingjie , Geleijnse Gijs , Kaptein Maurits 
Published: August 2023

Abstract
Despite the recent development of numerous methods aiming to estimate individual-level treatment effects based on observational data, assessing the validity of these estimates remains challenging. It is often unclear whether the observational data meet the assumptions imposed by a method. Additionally, there is often great flexibility in model choice when implementing a given method. This article introduces the R package RCTrep, designed for easy assessment of the validity of estimates of the average treatment effect obtained from observational data. This is achieved by a) making it easy to obtain and visualize estimates derived using a large variety of methods, and b) ensuring that these estimates are easily compared to a gold standard on population and subpopulation levels. RCTrep outlines a four-step workflow, namely, set-selection, estimation, diagnosis, and validation. The package provides a simple dashboard to review the obtained results. This article serves as a user guide for researchers aiming to leverage the potential of observational data to inform personalized treatment.
A novel study on the adsorption of low concentration Cd(II) and Ni(II) using porous boron nitride: effectiveness, coexisting anion interference, and regeneration
Authors: Han Fei , Zhao Mingyao , Ding Xun 
Published: August 2023

Abstract
The difficulty of removing low-concentration heavy metals from wastewater and the impact of coexisting anions on adsorption and regeneration performance has been widely recognized. To address this challenge, we synthesized and characterized a new adsorbent called porous boron nitride (PBN) using various techniques such as X-ray diffraction, Scanning Electron Microscopy, Fourier transform infrared spectroscopy and Brunner-Emmet-Teller measurements. We studied the adsorption kinetics and isotherms of Cd(II) and Ni(II) by PBN in the presence of interference anions using three kinetic models and four isothermal models. Our results showed that PBN reached adsorption equilibrium for Cd(II) and Ni(II) with a concentration of 10 mg/L within 5 minutes, and that the adsorption processes fit better with the pseudo-second order kinetic model and the Freundlich isothermal model. Furthermore, we found that the presence of SO42− inhibited the adsorption of Cd(II) and Ni(II), whereas SiO32−, CO32−, and PO43− promoted adsorption by forming a PBN-anion-metal ternary complex. We determined that the adsorption mechanism involved electrostatic attraction and chemisorption. After regeneration, PBN retained its crystal structure and typical pore distribution, demonstrating excellent adsorption performance for heavy metals.
Design of MIMO Microstrip Patch Antenna for 5G Applications
Authors: M Suresh Chinnathampy , A Ancy Marzla , L Dhivya Priya E , V Sneha 
Published: August 2023

Abstract
In this paper, a Microstrip Patch Antenna (MPA) is about to be designed. A dielectric material known as the substrate is sandwiched between a metallic patch and ground in an MPA. In comparison to the substrate and ground, a patch is smaller in size. The resonant frequency and dielectric constant value affect the size of a microstrip patch antenna. The proposed technology is a multi- input and multi-output microstrip patch antenna technology for wireless communications. The term "multiple inputs and multiple outputs" (MIMO) refers to a wireless technology that transfers more data between the transmitter and receiver at once to speed up data transmission and reduce mistakes. In essence, this idea refers to wireless network technology enabling access points or wireless routers to have many antennas. Simulating all antenna parameters, such as VSWR, balance, efficiencies, far field, and s-parameters, using CST Microwave Studio is the only way to verify the proposed antennas' performance.
HS-HA: Design of High-Speed Hardware Accelerator SOC for Biomedical Applications
Authors: Mavinkattimath Swati , Khanai Rajashri , Torse Dattaprasad , Iyer Nalini 
Published: August 2023

Abstract
Wireless Body Sensor Networks (WBSNs) consists of a Microcontroller used to process biosignals from sensors connected in or on the body. However, one of the issues observed in traditional WBSN is speed, which is addressed specifically in this work. This paper explains the operation of a Hardware Accelerator (HA) for WBSN consisting of four processing techniques Register bank, Predictor, Encryption, and Error Control Coding (ECC) implemented using Field Programmable Gate Array (FPGA) board PYNQ Z2 by TUL corporation. The improvements in the design of WBSN using HA are observed through the results of synthesis and implementation. The values of Worst Negative Slack (WNS) and utilization report represents the improvements in the design. HA’s floor planning and routing during Hardware-Software co-design produced a WNS of 0.269 ns. The proposed HA design in this paper utilizes 5.69k gate counts and consumes 0.227mW of power when operating at 250 MHz by using a 28-nm CMOS process.
Full-fat corn germ improves the performance and milk quality of lactating cows fed sugarcane bagasse and cactus cladodes as forage sources
Authors: Silva Camila , Gama Marco Antônio S. da , Silva Erick Alexandre M. , Ribeiro Emília F. , Felix Silas B. , Monteiro Carolina C.F. , Mora-Luna Robert E. , de Oliveira Júlio Cesar V. , Santos Djalma C. dos , Ferreira Marcelo de A. 
Published: August 2023

Abstract
the present study investigated the effects of replacing ground corn with full-fat corn germ on milk production, milk composition, and nutrient utilization in cows fed sugarcane bagasse and cactus cladodes. Ten multiparous Girolando cows (average body weight 500 ± 66 kg, 90 ± 15 days in milk) were distributed into a replicated 5 x 5 Latin Square, and assigned to five dietary treatments containing 0%, 25%, 50%, 75%, or 100% of full-fat corn germ in substitution to ground corn. Full-fat corn germ increased energy-corrected milk yield and synthesis of fat, lactose, and total solids in milk (p < 0.05). Cows fed corn germ quadratically increased (p < 0.05) intake of dry matter, crude protein, and total digestible nutrients, and linearly reduced (p < 0.05) the intake of total non-fiber carbohydrates. Except for ether extract and non-fiber carbohydrates, full-fat corn germ did not alter (p > 0.05) nutrient digestibility. Feeding corn germ reduced (p < 0.05) the excretion of urea-N in milk and N excretion via urine. These results demonstrate that full-fat corn germ can partially replace ground corn to enhance production efficiency in crossbred cows fed cactus cladodes and sugarcane bagasse. Furthermore, including sugarcane bagasse in FFCG-supplemented diets prevents milk fat depression in cows fed cactus cladodes.
Elimination of the RETNLB Gene Alleviates Intestinal Damage in NEC Mice
Authors: Xu Fen , Jin Zhenchao , Luo Jun 
Published: August 2023

Abstract
Background: The most serious gastrointestinal inflammation in newborns is necrotizing enterocolitis (NEC), which progresses quickly and has a high fatality rate. Resistin related molecule β (RELMβ) is highly concentrated in the intestines of both mice and humans according to earlier studies that have linked RELMβ to a variety of intestinal inflammatory disorders. Therefore, we hypothesized that targeting the RELMβ gene may inhibit inflammation and alleviate NEC in vivo.
Methods: First, RELMβ (RETNLB) knockout (KO) C57BL/6 mice were procured. Then, RETNLB KO mice and wild-type (WT) C57BL/6 mice were separated into 4 groups according to the NEC experimental model used for this study. The groups were as follows: group A consisted of WT mice, group B consisted of KO mice, group C consisted of WT mice with NEC, and Group D consisted of KO mice with NEC. Each group had 9 mice, and alterations in intestinal histology were analyzed. Expression levels of TLR2 and TLR4 in the intestinal tissues of each group were evaluated by simultaneous quantitative real-time polymerase chain reaction (qRT-PCR).
Results: Compared with WT mice, the expression levels of TLR2 and TLR4 were significantly up-regulated in WT mice following induction of NEC. Post-RETNLB KO, the expression levels of TLR2 and TLR4 in the KO group decreased significantly, and the differences were determined to be statistically significant (P<0.05). Interestingly, the degree of pathological damage to the intestines of KO mice was attenuated after induction of NEC. Compared with KO mice, there was no significant difference in the expression level of TLR4 in the KO NEC group (P>0.05); however, the expression level of TLR2 was significantly up-regulated (P<0.05).
Conclusion: RETNLB KO may exert a protective effect against intestinal injury in NEC mice through regulation of TLR4.
Extracurricular Physical Exercise Affects Teenagers' Expectation of Self-education and mechanism analysis-- Evidence from the CEPS Data
Authors: Xiao Qin , Tang Fengyun 
Published: August 2023

Abstract

Background: Extracurricular physical exercise is important in improving teenagers' expectations of self-education. However, in China, there are limited empirical analyses based on large microdata samples.
Methods: In this study, CEPS data and Ologit model are used to investigate the effect and mechanism of Extracurricular physical exercise on teenagers' self-education expectations.
Results: Extracurricular physical exercise can significantly improve teenagers' expectations of self-education; however, there are significant differences in the influence on teenagers with different characteristics. It can significantly increase the expectation of self-education among adolescents with different health levels, moderate and lower cognitive ability, moderate academic performance, relative confidence, and persistence while significantly decreasing the expectation of self-education among adolescents with poor academic performance. It does not significantly affect the self-education expectations of adolescents with higher cognitive ability and better academic performance.
Conclusions: The improvement of cognitive ability and academic performance, health level, and self-confidence are all important channels for the improvement of teenagers' expectations of self-education through extracurricular physical exercise.
Early versus Delayed Mobilization for Arthroscopic Rotator Cuff Repair: a Meta-analysis of Randomized Controlled Trials
Authors: Hu Ching-Wei , Tsai Sung Huang Laurent , Chen Chien-Hao , Tang Hao-Che , Su Chun-Yi , Tischler Eric H , Yang Yi-Chiang , Chan Yi-Sheng , Chiu Chih-Hao , Chen Alvin Chao-Yu 
Published: August 2023

Abstract
Background
The timing to start passive or active range of motion (ROM) after arthroscopic rotator cuff repair remains unclear. This systematic review and meta-analysis evaluates early versus delayed passive and active ROM protocols following arthroscopic rotator cuff repair. The aim of this study is to systematically review the literature on the outcomes of early active/passive versus delayed active/passive postoperative arthroscopic rotator cuff repair rehabilitation protocols.
Methods
A systematic review and meta-analysis of randomized controlled trials (RCTs) published up to April 2022 comparing early motion (EM) versus delayed motion (DM) rehabilitation protocols after arthroscopic rotator cuff repair for partial and full thickness tear was conducted. The primary outcome was range of motion (anterior flexion, external rotation, internal rotation, abduction) and the secondary outcomes were Constant-Murley score (CMS), Simple Shoulder Test Score (SST score) and Visual Analogue Scale (VAS).
Results
Thirteen RCTs with 1,082 patients were included in this study (7 RCTs for early passive motion (EPM) vs. delayed passive motion (DPM) and 7 RCTs for early active motion (EAM) vs. delayed active motion (DAM). Anterior flexion (1.40, 95% confidence interval (CI), 0.55–2.25) and abduction (2.73, 95%CI, 0.74–4.71) were higher in the EPM group compared to DPM. Similarly, EAM showed superiority in anterior flexion (1.57, 95%CI, 0.62–2.52) and external rotation (1.59, 95%CI, 0.36–2.82), compared to DAM. There was no difference between EPM and DPM for external rotation, retear rate, CMS and SST scores. There was no difference between EAM and DAM for retear rate, abduction, CMS and VAS.
Conclusion
EAM and EPM were both associated with superior ROM compared to the DAM and DPM protocols. Early mobilization may be suggested to improve ROM after arthroscopic surgery.
Endotaxial Stabilization of 2D Charge Density Waves with Long-range Order
Authors: Hovden Robert , Sung Suk Hyun , Agarwal Nishkarsh , Baggari Ismail El , Goh Yin Min , Kezer Patrick , Schnitzer Noah , Liu Yu , Lu Wenjian , Sun Yuping , Kourkoutis Lena , Heron John , Sun Kai 
Published: August 2023

Abstract
Charge density waves are emergent quantum states that spontaneously reduce crystal symmetry, drive metal-insulator transitions, and precede superconductivity. In low-dimensions, distinct quantum states arise, however, thermal fluctuations and external disorder destroy long-range order. Here we stabilize ordered two-dimensional (2D) charge density waves through endotaxial synthesis of confined monolayers of 1T-TaS2. Specifically, an ordered incommensurate charge density wave (oIC-CDW) is realized in 2D with dramatically enhanced amplitude and resistivity. By enhancing CDW order, the hexatic nature of charge density waves becomes observable. Upon heating via in-situ TEM, the CDW continuously melts in a reversible hexatic process wherein topological defects form in the charge density wave. From these results, new regimes of the CDW phase diagram for 1T-TaS2 are derived and consistent with the predicted emergence of vestigial quantum order.
Intake, digestibility, milk production, ingestive behavior and gas emissions of Saanen goats fed pornunça silage with levels of condensed tannin extracted from Schinopsis brasiliensis
Authors: Menezes Daniel Ribeiro , Carvalho Dalinne Tamara Queiroz , de Lucena Alita Ruth Ferraz , Marcelino Polyana Deyse Rodrigues , de Moura Lais Micaele Lopes , Queiroz Mário Adriano Ávila , de Moraes Salete Alves , Gois Glayciane Costa , Cruz Cláudia Horne da , Lima Anny Graycy Vasconcelos de Oliveira , Nascimento Thiago Vinicius Costa 
Published: August 2023

Abstract

The objective of this study was to determine the greatest concentration of condensed tannin (CT) extracted from Schinopsis brasiliensis in pornunça silages based on intake, digestibility, milk production, ingestive behavior and estimated greenhouse gas (GHG) emissions in dairy goats. Eight multiparous Saanen goats at 30 days of lactation, with 38.0 kg of initial body weight, production of 2.0 ± 0.4 kg of milk/day, mean age of 2–3 years, were distributed in a double Latin square (4x4) with four experimental periods and four diets with different tannin levels at concentrations 0% (control), 2.4, 3.6 and 4.8% tannin of total diet. The CT levels in the silage of pornunça promoted a linear decrease for the intake of dry matter (DM, P < 0.001), organic matter (OM, P < 0.001), ash (P < 0.001), crude protein (CP, P < 0.001), neutral detergent fiber (NDF, P < 0.001), acid detergent fiber (ADF, P < 0.001) and water (P < 0.001). The inclusion of CT also promoted a linear decrease in apparent digestibility coefficients of DM (P < 0.001), OM (P < 0.001) and CP (P < 0.001), milk production (P < 0.001), NDF (P < 0.001), and GHG emission estimation (P < 0.001). The intake and rumination rates of DM and NDF showed a linear decrease (P < 0.001) with level of tannin in the diets. In the experimental conditions, the inclusion of condensed tannin extracted from Schinopsis brasiliensis in pornunça silages, at levels up to 2.4% DM basis, promotes a decrease in intake of DM (DMI) and OM (OMI) and milk production as decreases GHG emissions in Saanen goats.
Citral in Lemon myrtle, Lemongrass, Litsea, and Melissa essential oils suppress the growth and invasion of breast cancer cells
Authors: Nagata Takuya , Satou Satoshi , Hayashi Shinichiro , Satyal Prabodh , Watanabe Manabu , Riggs Brannick , Saida Yoshihisa 
Published: August 2023

Abstract
Objective
Although cancer therapy suppresses recurrence and prolongs life, it may be accompanied by strong side effects; thus, there is a strong demand for the development effective treatments with fewer side effects. Cancer therapy using plant-derived essential oils is attracting attention as one promising method. This study investigated the antitumor effects of essential oil volatiles on breast cancer cells and identifies four essential oils that display antitumor activity.
Methods
Breast cancer cells were cultured in a 96-well plate, then one of twenty essential oils was added dropwise to the central well. The plate was incubated at 37°C for 48 h and the effect of the volatile components of each essential oil on the surrounding breast cancer cell growth ability was examined using an MTT assay. Gas chromatography was used to investigate the concentration of the transpiration components that may affect cancer cells.
Results
Of the 20 essential oils, Lemongrass, Lemon myrtle, Litsea, and Melissa displayed strong anti-tumor effects. These essential oils inhibited the growth of nearby breast cancer cells, even when diluted more than 500-fold. The transpiration component of lemon Myrtle showed the strongest antitumor effect, but was the least cytotoxic to mononuclear cells in normal peripheral blood (PBMC). Each of these essential oils contained a very large amount of citral. The IC50 against breast cancer cells when citral was volatilized from each essential oil was 1.67 µL/mL for geranial and 1.31 µL/mL for neral. Volatilized citral alone showed strong anti-proliferation and infiltration-inhibiting effects.
Conclusion
The transpiration components of Lemongrass, Lemon myrtle, Litsea, and Melissa are thought to inhibit breast cancer cell proliferation due to their high levels of citral.
A survey on the current status of Helicobacter pylori infection in households in Hainan Province
Authors: Liu Danni , Pan Jing , Chen Zhengyi , Li Sailian , Ma Jiamei , Xiao Yening , Wang Danhong , Mu Ganggang , Lin Ya , Li Juyuan , Chen Zhai , Huang Xiaoxi 
Published: August 2023

Abstract
Objective
This study aims to assess the prevalence of Helicobacter pylori (Hp) infection at the household level in Hainan Province and identify the factors that contribute to its spread. The findings of this study have significant implications for public health prevention strategies in the Hainan region.
Methods
A total of 421 families, comprising 1355 individuals, were tested for Hp infection across five cities in Hainan Province between July 2021 and April 2022. The study utilized questionnaires to identify potential factors linked to household Hp infection and transmission patterns.
Results
The prevalence of Hp infection on an individual basis was 46.72% (629/1355), with age ≥ 20 years, being married and having junior secondary education and above as risk factors for Hp infection. The prevalence of Hp infection in households was 80.29% (338/421), household size of 5, 6 and above were risk factors for Hp infection with Odds Ratios (ORs) of 4.09 (1.17–14.33) and 15.19 (2.01-114.73), respectively, household income ≥ 100,000 yuan and drinking boiled water from a tap source were protective factors for Hp infection with ORs of 0.52 (0.31–0.89) and 0.51 (0.28–0.95), respectively. The prevalence of Hp infection among minors in the household was 24.89% (58/233), with paternal infection and maternal infection as risk factors for child infection, with ORs of 2.93 (1.29–6.62) and 2.51 (1.07–5.89), respectively.
Conclusion
Hp infection was prevalent among Hainan families, and interaction with infected family members may be the primary cause of transmission.