bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengaruh Variasi Panjang Serat Tebu Sebagai Bahan Tambah Terhadap Indeks Perendaman Campuran AC-BC
Authors: Pareang Armin , Alpius  , Tanan Benyamin 
Published: April 2023

Tujuan dari penelitian ini adalah untuk mengetahui pengaruh variasi panjang serat tebu terhadap indeks perendaman campuran AC-BC ketika digunakan sebagai bahan aditif. Serat tebu ialah limbah organik yang dihasilkan oleh paprik gula. Dalam penelitian serat tebu di manfaatkan sebagai bahan tambah pada campuran aspal sebgai bahan pengikat aspal.. Melalui pengujian perendaman Marshall diperoleh campuran AC-BC dengan variasi panjang serat tebu 3 cm, 4 cm, 5 cm, 6 cm dan 7 cm terhadap durasi perendaman 0,5 jam dan 24 jam. Metode ini menggunakan beberapa uji pada karakteristik material agregat, dan filler, setelah itu dilakukan perancangan untuk campuran AC-BC dan dilakukan uji perendaman Marshall agar dapat diperoleh nilai indeks perendaman (IP),Indeks kekuatan sisa (IKS) dan durabilitas. Dari hasil pengujian tersebut dengan menggunakan metode uji perendaman Marshall dalam waktu 0,5 jam dan 24 jam maka didapatkan campuran AC-BC dengan variasi panjang serat tebu 3 cm, 4 cm, 5 cm, 6 cm, dan 7 cm. Hasil pengujian Marshall campuran AC-BC memperoleh Indeks Perendaman (IP), Indeks Kekuatan Sisa (IKS), dan Durabilitas yang dari pengujian tersebut didapatkan nilai IP rata-rata variasi panjang serat 3 cm yakni 93,20%, pada variasi panjang serat tebu 4 cm yaitu 93,35% pada variasi Panjang serat tebu 5 cm yaitu 95,15% pada variasi panjang serat tebu 6 cm yaitu 95,81% dan pada variasi panjang serat tebu 7 cm yaitu 98,92%.
The Therapeutic Effects of Ligustrazine in Combination with Other Drugs in Cardiovascular Diseases
Authors: Dong Peihua , Huang Yu , Pu Yujie 
Published: April 2023

Review
The Therapeutic Effects of Ligustrazine in Combination with Other Drugs in Cardiovascular Diseases

Peihua Dong , Yu Huang , and Yujie Pu ,*

Department of Biomedical Sciences, City University of Hong Kong, Hong Kong 518057 , China
* Correspondence: yujiepu@cityu.edu.hk

Received: 29 December 2022
Accepted: 18 January 2023
Published: 10 February 2023

Abstract: Chuanxiong, one of the traditional Chinese medicines (TCM), was first documented in the Tang dynasty to promote blood circulation and remove blood stasis. Ligusticum chuanxiong Hort was shown as the most effective portion of chuanxiong. Later chemical analysis revealed that the main chemical component of ligusticum chuanxiong Hort is tetramethylpyrazine. Since then, numerous explorations have been made to examine the efficiency of tetramethylpyrazine in treating different diseases and understand the underlying mechanisms of its action. Like Chuanxiong, ligustrazine (Chuan Xiong Qin) improved the functions of the circulatory and nervous systems. Ligustrazine (Chuan Xiong Qin) was also used in combination with other medicines to achieve better effects on improving cardiovascular health or alleviating the adverse effects of chemotherapies in both basic and clinical studies. The present review briefly summarizes the existing studies of the combination of ligustrazine (Chuan Xiong Qin) with other medicines in the treatment of cardiovascular diseases (CVDs) and provides valuable insights into the future research direction and better utilization of this drug.
Biological Functions and Applications of Exosomes in Drug Research
Authors: Fu Mengmeng , Li Jiapeng , Battulga Tungalag , Li Xiaoxue , Xu Ming 
Published: April 2023

Review
Biological Functions and Applications of Exosomes in Drug Research

Mengmeng Fu 1, Jiapeng Li 1, Tungalag Battulga 2, Xiaoxue Li 3, *, and Ming Xu 1, *

1 Department of Clinical Pharmacy, School of Preclinical Medicine and Clinical Pharmacy, China Pharmaceutical University, 24 Tong jia Lane, Nanjing 210009, China.
2 School of Pharmacy, Mongolian National University of Medical Sciences, Ulaanbaatar-24210, Mongolia.
3 Department of Cardiology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing 210009, China.
* Correspondence: lxx84112@163.com(Xiaoxue Li); mingxu@cpu.edu.cn; Tel.: 025-86185653(Ming Xu)

Received: 9 October 2022
Accepted: 12 November 2022
Published: 11 January 2023

Abstract: Exosomes have received increasing attention in recent years as an important substance for intercellular communication. Among the plethora of new research is their unique interaction with drugs is even more striking. Exosomes play essential roles in disease treatment either as extracellular vesicles to exert biological functions or as drug carriers to deliver therapeutic agents. We summarized the relationship between exosomes and drugs in the disease progression and treatment. Understanding how exosomes interact with drugs and exert their anti-inflammatory and pro-angiogenic effects, alongside a lipid peroxidation inhibitory result in different manners is essential for disease treatment.
Pengembangan Media Ajar Bahasa Indonesia Berbentuk Audio Visual Berupa Wayang
Authors: Zamnoor Putria Shalsha Ayu , Afifah Sindi Zahirotul , Rosalina Sinta 
Published: April 2023

Media pembelajaran adalah perantara yang digunakan untuk menyampaikan materi ke pelajar dengan menggunakan alat tertentu agar pelajar dapat mengerti dengan cepat dan menerima pengetahuan dari pengajar. Menurut Suprijanto (2009) menyatakan bahwa media audio visual adalah bahan atau alat yang dipergunakan dalam situasi belajar untuk membantu tulisan dan kata yang diucapkan dalam menularkan pengetahuan, sikap dan ide. Tujuan dari penelitian ini adalah untuk menghasilkan produk pengembangan media pembelajaran audio visual (teks, gambar, video, gerak) dan alat peraga berupa wayang berbahan bekas pada materi Teks Naratif dalam cerpen di kelas XI dalam meningkatkan pemahaman konsep serta dapat dijadikan sebagai media atau sumber belajar bagi siswa.
Pengaruh Tingkat Pendidikan dan Pengalaman Kerja terhadap Etos Kerja Karyawan
Authors: Riani Silva Okta , Putra Ivan Gumilar Sambas 
Published: April 2023

Sumber daya manusia (SDM) ialah faktor yang sangat berarti untuk memastikan keberhasilan perusahaan, sebab manusia ialah suatu makhluk yang memiliki pikiran, kebutuhan, perasaan, serta harapan tertentu. Di dalam sebuah perusahaan biasanya terdapat karyawan dengan latar belakang tingkat pendidikan yang berlainan dan pengetahuan yang berlainan, baik yang baru memulai dunia kerja ataupun yang telah berpengalaman kerja sebelumnya. Tujuan dari riset ini adalah dalam menelusuri pengaruh pengalaman kerja dan tingkat pendidikan pada etos kerja pegawai. Riset ini mempergunakan metode kuantitatif. Pada riset ini populasinya ialah semua pegawai PT. Nikkatsu Elektrik Works yang berjumlah 295 orang. Sampel pada riset ini dihitung dengan mempergunakan persamaan slovin dan hasilnya dengan jumlah 170 responden. Pengumpulan data mempergunakan kuesioner dan terlebih dahulu dilaksanakan uji coba reliabilitas dan validitas, pengujian asumsi klasik yang melingkupi pengujian normalitas, pengujian multikolinearitas, pengujian heterokedastisitas serta dilanjutkan dengan uji linearitas berganda, uji model F, koefisien determinasi dan uji hipotesis (Uji T) dengan bantuan software IBM SPSS. Temuan dari riset memperlihatkan bahwa tingkat pendidikan tidak mempengaruhi signifikan pada etos kerja dan pengalaman kerja mempengaruhi pada etos kerja.
Kelautan Indonesia Mempengaruhi Kerja Sama Bilateral Negara-Negara Tetangga untuk Menyelesaikan Masalah di Perairan Indonesia
Authors: Haris Moch , Feriyanti Nentin 
Published: April 2023

Pada tanggal 17 Agustus 1945, Ketika Indonesia merdeka, tidak diketahui berapa luas wilayah negara ini Sampai Akhirnya, pada tahun 1949, Konferensi Meja Bundar (KMB) diselenggarakan di Belanda Informasi tentang wilayah Indonesia Wilayah Indonesia diperluas 5.110 kilometer dari barat ke timur dan dari utara ke selatan 1.888 km2, luas 5.193.252 km2, dimana 1.890.754 km2 di pedesaan dan 3.302.498 km2 di pedesaan laut Sehingga Indonesia disebut negara Lautan atau Negeri Lautan. Oleh karena itu cocok untuk Indonesia tertarik pada pemantauan dan eksploitasi laut. namun Padahal, potensi sektor perkapalan belum tergarap secara maksimal. Oleh karena itu, pemerintah Republik Indonesia berusaha untuk membuat suatu kebijakan Pelayaran bertujuan untuk kesejahteraan rakyat.
Role of Counseling Media on Knowledge, Attitudes and Actions Women of Childbearing Age in IVA Examination at East Kolaka District
Authors: Harsup Moita Putri , Sunarsih Sunarsih , Fatmawati Fatmawati 
Published: March 2023

Introduction: Based on the 2019 of Regional Health Research, the early detection of cancer that has been carried out is the early detection of cervical cancer using the IVA method (Visual Inspection with Acetic Acid), which shows a decrease in IVA detection in each public health center and is still far from the national target of 100%. East Kolaka District is the area with the second lowest IVA examination rate at 0.08% while the first lowest IVA examination area is in Konawe District at 0.04% from 17 districts.
Method: This type of research is experimental research, a pre-experimental design with Four Groups Pretest-Posttest research design, was used to examine the role of the counseling media to the knowledge, attitudes and actions of women childbearing age in the IVA examination in East Kolaka District. The sample size of the respondents was 186 people.
Result: The Role models, FGDs, leaflets and whatsapp application had an effect on knowledge, attitudes and actions in the IVA examination in East Kolaka District.
Conclusion: Looking at the average increase in the result shows that whatsapp media was more effective in increasing knowledge, attitudes and actions than the other three media.
On Some Reflections of Profit and Loss Functions
Authors: KELEŞ Hasan 
Published: April 2023

This article is about the symmetrical reflections of profit and loss functions and the functions obtained from them, which are widely used in economic, economic and financial applications of mathematics. It is seen that the applications in the literature are calculated according to the profit and loss accounts alone. Since the occurrence of loss in an economic activity negatively affects the result of the profit, as a result of the loss, economic activity bankruptcy, etc. decisions are finalized. This has irreversible consequences. The controllability of these two interactive events poses reassuring risks. In short, it enables the manageability of the activity. Applications in life take place on a more real axis. To control, to see the whole event, thus providing the possibility of intervention. Therefore, it started with linear functions in the plane. Evaluations were made on the graphics here.
The system concepts existing in Mathematical Science, their results in applications, especially in economic activities in the market were examined and their symmetrical reflections with respect to each other were examined. Starting from the reflections of the known profit and loss functions, their interactions with each other were investigated [4]. How the break-even point was reflected according to these reflections, and therefore what they did was examined. The reflection of profit and loss functions according to another function was discussed. This makes it necessary for the control, planning and implementation of the situations observed in an economic activity, which are known in market economies. Therefore, it was emphasized that when the price will change in an economic activity, it will be more important to monitor and manage, and even at what stage the advertisements will be made, as a result of reflections. The loss curve is negatively sloping due to price, reflecting new information on the condition of its slope. It was emphasized that the reflections of the determining factors in marketing vary so much. As is known, prices simultaneously reflect both the value for the buyer of the next (or marginal) unit and the cost for the seller of that unit.
Analisis Aplikasi Sikar dengan Metode Triangulasi Pengelolaan Surat Masuk dan Keluar
Authors: Liang Maurico , Irawan Muhammad Dedi 
Published: April 2023

Judul penelitian ini adalah “Analisis Penggunaan Aplikasi SIKAR Dengan Metode Triangulasi Pengelolaan Surat Masuk dan Surat Keluar BPKAD PROVSU”. Tujuan dari penelitian ini adalah untuk mengetahui penggunaan aplikasi penyajian dalam pengelolaan surat masuk dan surat keluar pada suatu pada BPKAD PROVSU. Penelitian ini merupakan penelitian deskriptif kualitatif dengan menggunakan pendekatan studi kasus. Informan penelitian ini diperoleh dengan menggunakan metode Triangulasi. Metode pengumpulan data diperoleh melalui observasi, wawancara sebanyak dan dokumentasi. Hasil penelitian menunjukkan bahwa penggunaan aplikasi Tata surat pada BPKAD PROVSU berjalan dengan baik mulai dari pengelolaan surat masuk dan surat keluar hingga penyimpanan surat di aplikasi. Aplikasi ini juga berguna di bagian umum yang menangani fungsi manajemen surat menyurat. Masalah dari aplikasi SIKAR adalah aplikasi tidak memiliki pemindai file untuk mengirim email.
KAJIAN KEKONVERGENAN LEMAH DI RUANG HILBERT
Authors: M.Hasbi Abubakar Sidiq 
Published: March 2023

We have the sequence , where a norm space. We have a dual space too is the collection of linier and continous functional from norm space into riil number system . If for all the sequence convergent to and then convergent to . The converse of this implication is not applicable . This study aims to explain the properties that apply to the ranks of the weak convergent and explain the relationship between the strong convergent sequence and the weak convergent sequence. From several reference sources then through the review process obtained weak nature of singularity limit sequence and relationship between the strong convergent sequence and the weak convergent sequence that if the sequence is strong convergent therefore the sequence it weak convergent.
ANALISIS KESALAHAN SISWA DALAM MENYELESAIKAN SOAL MATEMATIKA MODEL PISSA PADA SISWA SMP
Authors: Dwi Shifa Sabillah  
Published: March 2023

Abstrak : Penelitian ini bertujuan untuk mendeskripsikan kesalahan siswa dalam menyelesaikan soal matematika dengan model PISA. Subjek penelitian ini yaitu siswa di SMP Negeri 21 Palembang dengan subjek siswa kelas VIII sebanyak 10 orang siswa. Penelitian ini menggunakan jenis penelitian eksperimen. Teknik pengambilan data pada penelitian kali ini adalah dengan tes tertulis, dan wawancara. Tes yang dilakukan yaitu dengan pemberian soal-soal matematika model PISA, sedangkan wawancara yang dilakukan dalam penelitian ini menggunakan pedoman wawancara tidak terstruktur. Teknik analisis data melalui reduksi data, penyajian data dan penarikan kesimpulan. Hasil penelitian yang diperoleh dari pengujian 5 soal tertulis, ternyata dapat dismpulkan bahwa rata-rata kesalahan siswa terbanyak yaitu pada soal nomor 2 sesuai dengan tipe-tipe kesalahan menurut Newman yaitu (1) kesalahan membaca sebanyak 8, (2) Kesalahan memahami sebanyak 10, (3) kesalahan mentransformasi 10, (4) kesalahan ketrampilan proses sebanyak 10, (5) kesalahan penulisan jawaban sebanyak 9.

Kata Kunci: Analisis, Kesalahan, Model PISA Soal Hots
ANALISIS PROSES BERPIKIR KRITIS SISWA DALAM PEMECAHAN MASALAH MATEMATIKA PADA POKOK BAHASAN POLA DAN BARISAN BILANGAN
Authors: Rukman Nia Kurniaty , Zulfikar Ryan Nizar , Noel Romanti Ester 
Published: March 2023

This study aims to analyze how students’ critical thingking processes in solving mathematical problems on the subject of patterms and sequences of numbers of students at SMP N 3 Fatuleu Tengah Satap. This study used a qualitative descriptive approach. Class VIII at SMP N 3 Fatuleu Tengah Satap, in solving patern and number sequence material questions the instrument provided in this study were 1) Critical Thingking test sheets, 2) Interviews, 3) Documentation. Documentation data analysis in this study,namely, 1) Data reducation, 2) presentation of data, 3) drawing conclusion/verivication based on data analysis, it can be concluded that 3 students with high mathematical abilities can go thourgh 4indicators and stages of the critical thingking process consisting of clarification (understand the problem), analysis (analysis the problem). Completion strategies (solving problems), and inference (making conclusions) on medium mathematical abilities students only go through the clarification and analysis stages but do not fulfill the strategy and inference stages and students with low mathematical abilities, namely students who interprect critical thingking on the answer sheet but are incomplete in answering.
Attack phenotypes and disease course in pediatric MOGAD
Authors: Santoro Jonathan D. , Beukelman Timothy , Hemingway Cheryl , Hokkanen Suvi R. K. , Tennigkeit Frank , Chitnis Tanuja 
Published: March 2023

AbstractMyelin oligodendrocyte glycoprotein antibody‐associated disease (MOGAD) is an autoimmune demyelinating condition that affects children differently than adults. We performed a literature review to assess the presentation and clinical course of pediatric MOGAD. The most common initial phenotype is acute disseminated encephalomyelitis, especially among children younger than five years, followed by optic neuritis (ON) and/or transverse myelitis. Approximately one‐quarter of children with MOGAD have at least one relapse that typically occurs within three years of disease onset and often includes ON, even if ON was not present at onset. Clinical risk factors for a relapsing course have not been elucidated.
Direct Observation of Magnetic Bubble Lattices and Magnetoelastic Effects in van der Waals Cr2Ge2Te6
Authors: McCray Arthur R. C. , Li Yue , Qian Eric , Li Yi , Wang Wei , Huang Zhengjie , Ma Xuedan , Liu Yuzi , Chung Duck Young , Kanatzidis Mercouri G. , Petford‐Long Amanda K. , Phatak Charudatta 
Published: March 2023

AbstractFerromagnetic van der Waals (vdW) materials are of large current interest for the fundamental study of low‐dimensional magnetism and for potential applications in multilayer heterostructures. Cr2Ge2Te6 (CGT) is particularly exciting because it is a ferromagnetic semiconductor with tunable electronic and magnetic properties. Controlling the magnetic domain structure of CGT is a requirement for understanding its novel interface physics and for tuning behavior for potential devices. Herein, cryo‐Lorentz transmission electron microscopy is performed in the temperature range of 12–50K to directly image the magnetic domain structures in CGT. A rich phase diagram of domain structures including stripe domains, magnetic bubble lattices of mixed‐chirality, and topologically‐protected lattices of homochiral magnetic bubbles is observed. The types and chiralities of the bubbles can be controlled by topographical changes in the CGT flakes. Additionally, it is observed that in‐plane strain and magnetoelastic coupling can align and organize both bubble lattices and stripe domains. This study provides insights into creating and controlling complex magnetic domain structures for integration into multilayer heterostructures and for future studies of 2D magnetism.
Tumor Immunophenotyping‐Derived Signature Identifies Prognosis and Neoadjuvant Immunotherapeutic Responsiveness in Gastric Cancer
Authors: Wang Jia‐Bin , Qiu Qing‐Zhu , Zheng Qiao‐Ling , Zhao Ya‐Jun , Xu Yu , Zhang Tao , Wang Shuan‐Hu , Wang Quan , Jin Qin‐Wen , Ye Yin‐Hua , Li Ping , Xie Jian‐Wei , Lin Jian‐Xian , Lu Jun , Chen Qi‐Yue , Cao Long‐Long , Yang Ying‐Hong , Zheng Chao‐Hui , Huang Chang‐Ming 
Published: March 2023

AbstractThe effectiveness of neoadjuvant immune checkpoint inhibitor (ICI) therapy is confirmed in clinical trials; however, the patients suitable for receiving this therapy remain unspecified. Previous studies have demonstrated that the tumor microenvironment (TME) dominates immunotherapy; therefore, an effective TME classification strategy is required. In this study, five crucial immunophenotype‐related molecules (WARS, UBE2L6, GZMB, BATF2, and LAG‐3) in the TME are determined in five public gastric cancer (GC) datasets (n = 1426) and an in‐house sequencing dataset (n = 79). Based on this, a GC immunophenotypic score (IPS) is constructed using the least absolute shrinkage and selection operator (LASSO) Cox, and randomSurvivalForest. IPSLow is characterized as immune‐activated, and IPSHigh is immune‐silenced. Data from seven centers (n = 1144) indicate that the IPS is a robust and independent biomarker for GC and superior to the AJCC stage. Furthermore, patients with an IPSLow and a combined positive score of ≥5 are likely to benefit from neoadjuvant anti‐PD‐1 therapy. In summary, the IPS can be a useful quantitative tool for immunophenotyping to improve clinical outcomes and provide a practical reference for implementing neoadjuvant ICI therapy for patients with GC.
Pathogenic genomic alterations in Chinese pancreatic cancer patients and their therapeutical implications
Authors: Zhao Zhiming , Li Xiaomo , Wang Fei , Xu Yong , Liu Si , Han Quanli , Yang Zhiying , Huang Weiwei , Yin Zhuzeng , Liu Qu , Tan Haidong , Ma Tonghui , Si Shuang , Huang Jia , Yuan Hongling , Li Wei , Liu Rong 
Published: March 2023

AbstractBackgroundApproximately 90% of pancreatic ductal adenocarcinoma (PDAC) cases are driven by the untargetable non‐G12CKRASmutations, and only a small subset of patients are eligible for FDA‐approved precision therapies. The practice of precision therapy in pancreatic cancer was limited by the paucity of targetable genetic alterations, especially in the Asian population.MethodsTo explore therapeutic targets in 499 Chinese PDAC patients, a deep sequencing panel (OncoPanscan™, Genetron health) was used to characterize somatic alterations including point mutations, indels, copy number alterations, gene fusions as well as pathogenic germline variants.ResultsWe performed genomic profiling in 499 Chinese PDAC patients, which revealed somatic driver mutations inKRAS,TP53,CDKN2A,SMAD4,ARID1A,RNF43, and pathogenic germline variants (PGVs) in cancer predisposition genes includingBRCA2,PALB2, andATM. Overall, 20.4% of patients had targetable genomic alterations. About 8.4% of patients carried inactivating germline and somatic variants inBRCA1/2andPALB2, which were susceptible to platinum and PARP inhibitors therapy. Patients withKRASwild‐type disease and early‐onset pancreatic cancer (EOPC) harbored actionable mutations includingBRAF,EGFR,ERBB2, andMAP2K1/2. Compared to PGV‐negative patients, PGV‐positive patients were younger and more likely to have a family history of cancer. Furthermore, PGVs inPALB2,BRCA2, andATMwere associated with high PDAC risk in the Chinese population.ConclusionsOur results demonstrated that a genetic screen of actionable genomic variants could facilitate precision therapy and cancer risk reduction in pancreatic cancer patients of Asian ethnicity.
Design of a broadband power amplifier based on high‐efficiency impedance space
Authors: Wang Jingying , Yao Ruohe , Xiong Zhenting , Qin Jian , Wang Hong 
Published: March 2023

SummaryWe propose a broadband high‐efficiency power amplifier (PA) with output power between 42.6 and 44.7 dBm, drain efficiency (DE) over 62%, and power additional efficiency (PAE) over 52% in the 2.3–3.5GHz frequency band. This PA effectively combines the high‐efficiency characteristics of class‐F PAs with the advantages of controlling the second harmonic for obtaining high efficiency at large bandwidth. The Dual Band Harmonic Control and Matching Network (DBHCN) realizes the conversion from 50 Ω to high‐efficiency impedance space (HEIS) while controlling the high‐order harmonics in different frequency bands. The proposed PA can be used for the fifth‐generation mobile communication technology (5G) base stations and broadband radars.