bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analisis Sentimen Ulasan Penjualan UMKM Sosial Melalui Media Dengan Crowdtangle masa Pandemi Covid19
Authors: Ridho Muhammat Rasid , Arnomo Sasa Ani , Fajrah Nofriani , Fifi Fifi 
Published: July 2023

Pada saat terjadi bencana Covid 19 ini banyak beberapa negara melakukan lockdown dan membuat peraturan untuk melakukan jaga jarak, sehingga menyebabkan pemanfaatan sosial media naik signifikan. Peneliti mempunyai rencana untuk melihat pengguna media sosial melakukan ulasan maupun komenter dalam melakukan proses jual beli. Baik komentar positif maupun negatif akan kita kumpulkan. Adapun tujuan penelitian ini adalah untuk mengetahui cara peneliti melakukan pengumpulan data ulasan dari pelanggan, untuk mengetahui respon konsumen terhadap produk yang dijual oleh UMKM melalui sosial media Facebook. Metode yang dipakai adalah Analisis Sentimen dimana suatu tahapan guna menjawab dan menentukan angka opini maupun sentimen yang ada pada sebuah keadaan atau object yang dapat berwujud tulisan dan bisa dibedakan dalam sentimen negatif, positif, atau netral. Adapun hasilnya dari melakukan analisis sentimen pada penjualan produk UMKM di Kota Batam dapat dilihat tingkat untuk akurasinya 91% serta 0,97 UAC menggunakan metode Support Vector Machine.
Mandatory Wills for Adultery Children, Analysis of the Compilation of Islamic Law from the Perspective of Maqasid Syariah Al-Syatibi
Authors: Arifin Zainal , Mahmudi Zaenul 
Published: July 2023

Over time, the development of Islamic law in Indonesia shows relatively rapid growth, both from the institutionalization of law and contemporary Islamic studies. One of them is the mandatory will listed in the Compilation of Islamic Law (KHI) Article 209 Paragraphs 1 and 2. The mandatory will intended in this KHI is the taking of property from the adoptive parent for the adopted child or from the adopted parent for the adoptive parent through a mandatory decision of the award, whether the deceased person pronounces or writes the will when living or not. This KHI is a set of Islamic laws that are the product of Indonesian scholars to answer problems in the community and become a formal reference of judges in deciding a case. Tururanan, from the will of the obligation in the KHI, can then be implemented a mandatory will for adultery children as a protection against it. This article uses the library research approach and philosophical qualitative-juridical methods, then analyzed using maqasid shari'ah al-Syatibi, in terms of propositions, illah, and maslahat justice by the purpose of shari'ah. Whether the concept of compulsory will for adulterous children is under the objectives of sharia to create ummat benefits or not, the results can later be used as references and evaluation materials by legal experts and legal practitioners in the termination of the court and study materials for academics.
IMPACTOS SOCIOAMBIENTAIS DA MINERAÇÃO: EXTRACÇÃO ARTESANAL DA PEDRA NO POSTO ADMINISTRATIVO DE LUSSIMBESSE, DISTRITO DE SANGA
Authors: Bonomar Silvino de Aguiar Francisco , Wilson Vasco Armindo 
Published: July 2023

A mineração artesanal da pedra é um fenómeno crescente na província do Niassa. As comunidades do posto administrativo de Lussimbesse recorrem a esta prática para o seu sustento e renda económica. O artigo assente a uma abordagem qualitativa recorrendo a consulta bibliográfica, documental, entrevista semiestruturada e observação directa seguida de imagens e analisa os impactos socioambientais da mineração, na extracção artesanal da pedra no posto administrativo de Lussimbesse. Visa a caracterizar os aspectos socioeconómicos; descrever os impactos ambientais e propor acções de mitigação dos impactos desta actividade sobre o meio ambiente. Os resultados denotam que a actividade na área do estudo é corolário da procura de melhores condições de vida, entretanto, esta acção tem causado impactos negativos sobre o meio ambiente.

Palavras-chave: mineração; pedra; impactos socioambientais.
Papel del ejercicio físico en la prevención de la diabetes gestacional
Authors: Aguado Pérez de Rojas Sara , García Prieto Antonio 
Published: July 2023

Introducción y objetivo. La relación entre ejercicio físico y embarazo ha evolucionado hasta establecerse como recomendación básica de salud dada la cantidad de beneficios que su práctica supone, especialmente, su influencia sobre la diabetes gestacional.
La occidentalización de las sociedades, ha incrementado los factores de riesgo para la aparición de diabetes gestacional y las consecuencias materno-fetales asociadas. El objetivo de esta revisión bibliográfica es la exposición de las principales variables relacionadas con la diabetes gestacional y planteamiento de intervención sanitaria enfermera sobre las gestantes.
Metodología. Búsqueda bibliográfica de términos “ejercicio físico”, “diabetes gestacional”, “embarazo” realizada en las bases de datos PubMed, Scielo, Cochrane, Cinalh, Dialnet, Catálogo CISNE y Enferteca, con selección total de 25 artículos.
Conclusiones. Actualmente, las intervenciones más eficaces para la prevención de diabetes gestacional en gestantes combinan dieta y ejercicio físico. Sin embargo, ciertos tipos de ejercicio físico pueden prevenir el desarrollo de diabetes gestacional y factores de riesgo asociados. Se considera necesario realizar un mayor número de intervenciones heterogéneas para respaldar estos resultados. El planteamiento de intervención sanitaria monofactorial centrada en la práctica de ejercicio físico en embarazadas, podría ayudar en la prevención de esta patología.
“A Terrible Beauty Is Born”: Opportunities and New Perspectives for Online Teaching and Assessment
Authors: Poppi Franca , Schmied Josef 
Published: July 2023

Even though the use of digital tools as an alternative to or in support of more traditional methods is no longer considered a novelty in the context of language learning, as a consequence of the outbreak of the Covid-19 pandemic, what used to be an opportunity was transformed into a pressing and inevitable necessity that led all the actors involved in the training and evaluation process to radically change their way of teaching and assessing. Within a matter of days, educators around the world scrambled to shift their practice from in-person to remote teaching. The need to maintain social distancing prompted the transition to Emergency Remote Teaching (ERT). Even though globally the emergency posed by Covid-19 popularized ERT as a temporary intervention to complete a higher education academic year, ERT has undoubtedly proved to be a feasible alternative for “students unconventionally dispersed, either locally or abroad, when only limited contact to educational facilities and instructional materials for their learning needs is available” (Nokukhanya et al. 2021, 9). Indeed, since in remote teaching the participants in the communicative act mainly interact via a screen, and sometimes even without full access to video facilities, at times there may be the tendency to de-emphasize person-to-person contact. Therefore, if we want remote teaching to provide new opportunities and stimuli in the future, it is essential to draw on the examples of good practice emerged during the pandemic, bearing in mind that teachers and educators should first and foremost promote interactive activities at the most efficient and realizable rate, with a view to encouraging the attendees’ notivation and participation.
Association Between Genotype and Phenotype Severity in ABCA4-Associated Retinopathy
Authors: Bianco Lorenzo , Arrigo Alessandro , Antropoli Alessio , Manitto Maria Pia , Martina Elisabetta , Aragona Emanuela , Bandello Francesco , Battaglia Parodi Maurizio 
Published: July 2023

ImportanceABCA4-associated retinopathy is a common inherited retinal disease, and its phenotype spans from late-onset macular dystrophy to extensive cone-rod degeneration. Over 2000 disease-causing variants in the ABCA4 gene have been identified.ObjectiveTo investigate genotype-phenotype correlations in ABCA4-associated retinopathy.Design, Setting, and ParticipantsThis cohort study took place at a single referral center for inherited retinal diseases in Italy. Data were prospectively acquired from January 2015 to June 2022. Patients diagnosed with an inherited retinal disease related to biallelic ABCA4 variants were included for analysis.ExposureGenotype, classified into 4 groups according to the presence of the (1) p.Gly1961Glu allele, (2) a hypomorphic allele, (3) at least 1 moderate variant (moderate genotypes), or (4) 2 biallelic severe variants (severe genotypes).Main Outcomes and MeasuresTotal decreased autofluorescence (TDAF) and definitely decreased autofluorescence (DDAF) areas, inner and outer retinal volumes, and the respective progression rate.ResultsA total of 71 patients (median [IQR] age, 34 [22.4-47.2] years; 40 [56%] female) were included in the study, and 54 (76%) were followed up for a median (IQR) of 3.5 (1.6-4.7) years. Compared with moderate genotypes, those with the p.Gly1961Glu allele had smaller TDAF lesions by 61% (95% CI, −78% to −33%; P &amp;lt; .001) and DDAF lesions by 77% (95% CI, −93% to −18%; P = .02), along with slower growth rates for both TDAF (0.05 mm/y; 95% CI, 0.01-0.07; P &amp;lt; .001) and DDAF (0.06 mm/y; 95% CI, 0-0.12; P = .004). Hypomorphic alleles were associated with a thicker inner (+0.19 mm3; 95% CI, +0.02 to +0.36; P = .03) and outer retinal volume (+0.16 mm3; 95% CI, +0.03 to +0.28; P = .01) compared with moderate genotypes as well as a slower TDAF growth rate (0.05 mm/y; 95% CI, 0.01-0.08; P = .007). Severe genotypes had a 7-fold larger TDAF area (95% CI, 3.4-14.7; P &amp;lt; .001) and 11-fold larger DDAF area (95% CI, 2.9-42.1; P &amp;lt; .001) compared with moderate genotypes, along with faster growth rates estimated at 0.16 mm/y for TDAF (95% CI, 0.12-0.20; P &amp;lt; .001) and 0.17 mm/y for DDAF (95% CI, 0.12-0.23; P &amp;lt; .001).Conclusions and RelevanceIn this study of ABCA4-associated retinopathy, a 4-tier classification of genotypes was found to capture substantial variation in disease phenotype severity. These findings could prove beneficial for the prognostication of patients and warrant consideration of genotype in the design of future clinical trials.
Exploring Olfactory Dysfunction as a Marker of Frailty and Postoperative Outcomes in Head and Neck Cancer
Authors: Mady Leila J. , De Ravin Emma , Vohra Varun , Lu Joseph , Newman Jason G. , Hall Daniel E. , Dalton Pamela H. , Rowan Nicholas R. 
Published: July 2023

ImportanceOlfactory dysfunction (OD) is increasingly recognized as a robust marker of frailty and mortality. Despite broad recognition of frailty as a critical component of head and neck cancer (HNC) care, there is no standardized frailty assessment.ObjectiveTo assess the prevalence of OD and its association with frailty and postoperative outcomes in HNC.Design, Setting, and ParticipantsIn this prospective cohort study with enrollment between February 17, 2021, to September 29, 2021, at a tertiary academic medical center, 85 eligible adult patients with primary, treatment-naive HNC of mucosal or cutaneous origin were included. Patients with a history of COVID-19, neurocognitive, or primary smell/taste disorders were excluded.ExposuresProspective olfactory assessments (self-reported, visual analog scale [VAS] and psychophysical, University of Pennsylvania Smell Identification Test [UPSIT]) with concurrent frailty assessment (Risk Analysis Index [RAI]) were used. Olfactory-specific quality of life (QOL) was examined with brief Questionnaire of Olfactory Disorders–Negative Statements (QOD-NS).Main Outcome(s) and Measure(s)The primary outcome was the prevalence of OD as assessed by VAS (0-10, no to normal smell) and UPSIT (0-40, higher scores reflect better olfaction) and its association with frailty (RAI, 0-81, higher scores indicate greater frailty). For surgical patients, secondary outcomes were associations between OD and postoperative length of stay (LOS), 30-day postoperative outcomes, and QOD-NS (0-21, higher scores indicate worse QOL).ResultsAmong 51 patients with HNC (mean [SD] age, 63 [10] years; 39 [77%] male participants; 41 [80%] White participants), 24 (47%) were frail, and 4 (8%) were very frail. Despite median (IQR) self-reported olfaction by VAS of 9 (8-10), 30 (59%) patients demonstrated measured OD with psychophysical testing. No meaningful association was found between self-reported and psychophysical testing (Hodges-Lehmann, &amp;lt;0.001; 95% CI, −2 to 1); a total of 46 (90%) patients did not report decreased olfaction-specific QOL. Median UPSIT scores were lower in frail patients (Hodges-Lehmann, 6; 95% CI, 2-12). Multivariate modeling demonstrated severe microsmia/anosmia was associated with 1.75 (95% CI, 1.09-2.80) times odds of being frail/very frail and approximately 3 days increased LOS (β, 2.96; 95% CI, 0.29-5.62).Conclusions and RelevanceAlthough patients with HNC are unaware of olfactory changes, OD is common and may serve as a bellwether of frailty. In this prospective cohort study, a dose-dependent association was demonstrated between increasing degrees of OD and frailty, and the potential utility of olfaction was highlighted as a touchstone in the assessment of HNC frailty.
Fluorinated Elastomers
Authors: Ameduri Bruno 
Published: July 2023

AbstractFluorinated elastomers (FEs) are unique materials bearing exceptional properties and involved in High Tech applications (electronics, car, aerospace, and petrochemical industries and microelectronics) where they resist to stringent conditions, showing peculiar softness and resilience over a wide range of temperatures. This article mainly reports on (per)fluorocarbon elastomers, fluorophosphazenes, fluorosilicones, and perfluoropolyethers as well as controlled thermoplastic elastomers for which several properties and applications are provided.
Ultrathin PtNiGaSnMoRe Senary Nanowires with Partial Amorphous Structure Enable Remarkable Methanol Oxidation Electrocatalysis
Authors: Yang Furong , Ye Jinyu , Gao Lei , Yu Jingwei , Yang Zhilong , Lu Yangfan , Ma Chao , Zeng Yu‐Jia , Huang Hongwen 
Published: July 2023

AbstractFinding a high CO‐tolerance Pt‐based catalyst plays a critical role for direct methanol fuel cells. Therefore, it is necessary to design controllable nanostructure and composition. Herein, a synthesis of ultrathin PtNiGaSnMoRe senary nanowires (SNWs) that features the virtues of partial amorphous structure, multimetallic ensembles, and ultrathin diameter is reported. For the alkaline methanol oxidation reaction (MOR), the SNWs deliver an excellent mass activity of 6.2 A mg−1Pt and a specific activity of 12.3 mA cm−2, respectively. More significantly, after undergoing 10 000 s of a durability test, its mass activity remains 13.0 times higher than that of commercial Pt/C catalyst, which is mainly attributed to the faster CO‐intermediate (CO*) removal and advanced nanostructure. In situ Fourier transform infrared (FTIR) spectroscopies and CO stripping experiments indicate its remarkable resistance to CO poisoning. Theoretical studies further reveal that the SNWs enable reduced energy barriers for the conversion of CO* into COOH* derived from the decreased CO* binding and intensified OH adsorption that accelerate the combination of both, thus essentially improving the MOR performance and CO tolerance.
SLN124, a GalNAc conjugated 19‐mer siRNA targeting tmprss6, reduces plasma iron and increases hepcidin levels of healthy volunteers
Authors: Porter John B. , Scrimgeour Alison , Martinez Alberto , James Leo , Aleku Manuela , Wilson Rosamund , Muckenthaler Martina , Boyce Malcolm , Wilkes Denise , Schaeper Ute , Campion Giles V. 
Published: July 2023

AbstractSLN124, an N‐acetylgalactosamine conjugated 19‐mer short interfering RNA, is being developed to treat iron‐loading anemias (including beta‐thalassemia and myelodysplastic syndromes) and myeloproliferative neoplasms (polycythemia vera). Through hepatic targeting and silencing of the TMPRSS6 gene, SLN124 increases endogenous hepcidin synthesis. This is the first clinical report of an siRNA targeting a component of iron homeostasis. This first‐in‐human, phase 1 study assessed the safety, tolerability, pharmacokinetics, and pharmacodynamics of single ascending doses of SLN124 (1.0, 3.0, and 4.5 mg/kg) in healthy volunteers. Twenty‐four participants were randomized in three sequential cohorts of eight subjects, each to receive a single dose of either SLN124 or placebo (6:2 randomization), administered subcutaneously. There were no serious or severe adverse events, or discontinuations due to adverse events, and most treatment‐emergent adverse events were mild, including transient mild injection site reactions, resolving without intervention. SLN124 was rapidly absorbed, with a median tmax of 4–5 h across all treatment groups, and largely eliminated from plasma by 48 h. Plasma concentrations increased in a greater than dose proportional fashion between treatment groups. In all SLN124 groups, a dose‐related effect was observed across iron metabolism markers, and across erythroid markers, SLN124 resulted in increased plasma hepcidin levels, peaking around Day 29, and consequent dose‐related sustained reductions in plasma iron and transferrin saturation with decreased reticulocyte production, MCHC, and MCV. Results suggest duration of action lasting up to 56 days after a single SLN124 dose, on hepcidin and hematological parameters of iron metabolism (serum iron and TSAT).
Copolymers of poly(aryl ether ketone)/poly(ether ether amide) containing different numbers of methylene in the main chain: Synthesis and properties
Authors: Jiang Lishi , Li Xiaoyu , Dai Junyu , Zefeng Niu , Gou Sha , Gu Ling , Luo Shajie 
Published: July 2023

Abstract“One‐step polymerization method” was used to improve the thermal property of semi‐aromatic poly(ether ether amide) (PEEA). Firstly, a series of difluorobenzamide monomers containing different numbers of methylene were synthesized by the reaction of diamine and 4‐fluorobenzoic chloride using a facile interfacial reaction method. Then, these syntheses were conducted to react with bisphenol AP and 4,4′‐difluorobenzophenon to synthesize the novel poly(aryl ether ketone)/semi‐aromatic poly(ether ether amide) copolymers (PAEK/PEEA) with different chain lengths in the chain through nucleophilic substitution by a one‐step method. The obtained copolymers were amorphous with inherent viscosities of 0.373–0.433 dLg−1. They were found to have high glass transition temperatures (Tg) of 160–191°C, good thermal stability with 5% weight‐loss temperature (T5%) of 409–437°C. The tensile strengths of the copolymers were 65.0–75.8 MPa. The storage modulus were over 0.9 GPa at 120°C. At room temperature, the copolymers were soluble in NMP, slightly soluble in DMF, CH2Cl2, CH3Cl, indicating that the synthesized copolymers could be processed by solution method. The results of optical performance showed that the copolymers had good optical transmittance with the optical transmittance of 75.7%–86.1% at 450 nm. They have the potential to be applied as the novel heat‐resistance optical films as the novel copolymers.
6‐Aminocoumarin oxime‐ether/sulfonamides as selective hCA IX and XII inhibitors: Synthesis, evaluation, and molecular dynamics studies
Authors: Ghouse Shaik Mahammad , Sinha Kareena , Bonardi Alessandro , Pawar Gaurav , Malasala Satyaveni , Danaboina Srikanth , Mohammed Arifuddin , Yaddanapudi Venkata M. , Supuran Claudiu T. , Nanduri Srinivas 
Published: July 2023

AbstractCarbonic anhydrase isoforms IX and XII are overexpressed in hypoxic tumor cells regulating various physiological processes such as cell proliferation, invasion, and metastasis, resulting in the onset and spread of cancer. Selective inhibition of these enzymes is a promising strategy for anticancer therapy. Coumarin derivatives were identified as selective and potent inhibitors of these isoforms. This study reports 6‐aminocoumarin sulfonamide and oxime ether derivatives linked through a chloroacetyl moiety tethered to piperazine and piperidone, respectively, showing selective inhibition against human carbonic anhydrase (hCA) IX and XII with Ki ranging from 0.51 to 1.18 µM and 0.89–4.43 µM. While the sulfonamide derivative 8a exhibited submicromolar inhibition against hCA IX and XII with Ki 0.89 and 0.51 µM, the oxime ether derivatives showed lower activity than the sulfonamides, with the compound 5n inhibiting hCA IX and hCA XII with a Ki of 1.055 and 0.70 µM, respectively. The above results demonstrate the potential of these derivatives as selective, potent inhibitors of carbonic anhydrase IX and XII and provide a foundation for further optimization and development as effective anticancer agents. Further, the binding mode of the synthesized derivatives in the active site were examined using molecular docking and dynamic simulation studies.
Structural, morphological, and optical characteristics of Gd2Si2O7:Dy3+ nanophosphors for WLEDs
Authors: Gupta Isha , Singh Devender , Kumar Pawan , Singh Sitender , Bhagwan Shri , Kumar Vinod 
Published: July 2023

AbstractYellowish‐white light‐emitting Gd2‐xSi2O7:xDy3+ (x = 1–5 mol%) nanophosphors were prepared using a solution combustion synthesis method. Fluorescence spectrophotometry and X‐ray diffraction measurements were performed to scrutinize the optical performances and phase recognition of the designated nanophosphors. The outcomes specified that the prepared phosphors were crystallized into a triclinic phase with a P‐1 space group. As the concentration of Dy3+ ions was increased, the unit‐cell volume decrease proportionally due to the replacement of large‐sized Gd3+ by small‐sized Dy3+ ions. Under ultraviolet excitation at 349 nm, emission spectra consisted of two pronounced emission lines at ~482 nm (blue line), ~578 nm (yellow line), and a relatively weaker emission at ~670 nm (red line) due to 4F9/2→6H15/2, 4F9/2→6H13/2, and 4F9/2→6H11/2 intraconfigurational transitions of Dy3+ ions, respectively. The evidence about the site symmetry around Dy3+ ions was examined by considering the ratio of yellow‐to‐blue emission intensity. The observed critical distance (Rc) value was ~20.56 Å (≫5 Å), which signified that energy transfer primarily occurred due to multipolar interaction. The obtained coordinates were close to the white region of the Commission Internationale de l'Éclairage chromaticity diagram, which marked a significant milestone in the development of white light‐emitting diodes.
Organo‐Functionalized Lacunary Double Cubane‐Type Oxometallates: Synthesis, Structure, and Properties of [(MIICl)2(VIVO)2{((HOCH2CH2)(H)N(CH2CH2O))(HN(CH2CH2O)2)}2] (M=Co, Zn)
Authors: Shuaib Damola T. , Swenson LaSalle , Kaduk James A. , Chang Tieyan , Chen Yu‐Sheng , McNeely James , Khan M. Ishaque 
Published: July 2023

AbstractOrganofunctionalized tetranuclear clusters [(MIICl)2(VIVO)2{((HOCH2CH2)(H)N(CH2CH2O))(HN(CH2CH2O)2)}2] (1, M=Co, 2: M=Zn) containing an unprecedented oxometallacyclic {M2V2Cl2N4O8} (M=Co, Zn) framework have been prepared by solvothermal reactions. The new oxo‐alkoxide compounds were fully characterized by spectroscopic methods, magnetic susceptibility measurement, DFT and ab initio computational methods, and complete single‐crystal X‐ray diffraction structure analysis. The isostructural clusters are formed of edge‐sharing octahedral {VO5N} and trigonal bipyramidal {MO3NCl} units. Diethanolamine ligates the bimetallic lacunary double cubane core of 1 and 2 in an unusual two‐mode fashion, unobserved previously. In the crystalline state, the clusters of 1 and 2 are joined by hydrogen bonds to form a three‐dimensional network structure. Magnetic susceptibility data indicate weakly antiferromagnetic interactions between the vanadium centers [Jiso(VIV−VIV)=−5.4(1); −3.9(2) cm−1], and inequivalent antiferromagnetic interactions between the cobalt and vanadium centers [Jiso (VIV−CoII)=−12.6 and −7.5 cm−1] contained in 1.