bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preference Constellations in EU–Russian Crisis Bargaining over Syria and Ukraine
Authors: Driedger Jonas J. , Krotz Ulrich 
Published: September 2023

AbstractThe Russian invasion of Ukraine in early 2022 and the ensuing EU–Russian clash over the fate of Ukraine highlight the importance of explaining the outcomes of EU–Russian crisis bargaining. Complementing existing accounts, we argue that favourable preference constellations are key: The more determined, united and focused side prevails over its less interested, divided or unfocused counterpart. We first establish the inferiority of Russia's influence assets (economic, military, normative and allies) relative to the EU. We then use congruence analysis to reverse‐engineer crisis bargaining outcomes in key cases of EU–Russian crisis bargaining, showing that favourable preference constellations allowed Russia, despite inferior assets and EU opposition, to ensure Syrian dictator Assad's political survival, finalize the annexation of Crimea in 2014 and keep Donbass out of Kyiv's control since then. Finally, we discuss the implications of these findings for related areas, as well as for current and future EU–Russian crisis bargaining, specifically over Ukraine.
Age estimates derived from hard parts of swordfish Xiphias gladius from the north‐western Mediterranean Sea
Authors: Millot Rémi , Vanalderweireldt Lucie , Finelli Sandolo Laure , Durieux Eric D. H. 
Published: September 2023

AbstractAccurate age estimates for fish are critical for properly understanding stock dynamics and health; this is particularly true for larger billfishes. Here we determined the most accurate aging estimation methods for swordfish (Xiphias gladius). We compared age estimates obtained from fin‐ray sections, otolith sections, whole otoliths, and vertebrae collected from 87 swordfish off the east coast of Corsica. Age estimates from otolith sections were most consistently estimated across different readers (lowest average percentage error), followed by fin‐ray sections, third vertebrae, and whole otoliths. When the age estimates from the otolith sections were compared with the other three age sclerochronological methods, we found the average percentage error to be lowest between the otolith section and fin‐ray methods. However, age estimates from fin rays proved most useful for estimating swordfish younger than 6 years, as the fin ray‐based age diverged from that of the otolith sections as the swordfish aged. Combining fin ray and otolith section techniques, we estimated the growth parameters of 1–12‐year‐old females (L∞ = 259.412, k = 0.113, t0 = −2.499) and 1–7‐year‐old males (L∞ = 175.543, k = 0.202, t0 = −2.239). We found that females grew significantly faster than males after 3 years and remained larger thereafter. Our calculated growth rates for this region of the north‐western Mediterranean Sea were lower than those of the Atlantic, Pacific, and eastern Mediterranean Sea swordfish populations, and similar to growth rates recorded for the western Mediterranean Sea populations. Our study provides critical knowledge on biological‐related parameters to serve as a guide for preserving the swordfish population in the Mediterranean Sea.
Heterochrony and the evolution of the longjaw mudsucker (Gobiidae, Teleostei)
Authors: Milan Jimjohn , Fidel Tyler , Hongjamrassilp Watcharapong , Frable Benjamin W. , Skelton Zachary R. , Hastings Philip A. 
Published: September 2023

AbstractAlthough longjaw mudsucker (Gillichthys mirabilis, Gobiidae) has been studied extensively for its ability to occupy low‐oxygen environments, few studies have addressed the evolution of its exceptionally elongated jaws that extend posteriorly beyond the gill opening in large adults. In this study, the ontogeny of the maxillae of G. mirabilis, Gillichthys seta, and the out‐group species Eucyclogobius newberryi was studied within the heterochrony framework using digitized landmarks and caliper measurements. The results show that the maxilla of both species of Gillichthys evolved via acceleration (increased growth rate) and that of G. mirabilis via hypermorphosis (continued growth to a larger body size); two forms of peramorphosis. This is in contrast to earlier studies that concluded that G. seta is paedomorphic. We were unable to confirm an earlier hypothesis of sexual dimorphism in the jaw length of G. mirabilis. The evolution of the elongated jaws and associated large buccopharyngeal membrane in G. mirabilis is hypothesized to increase the surface area for gas exchange during aerial respiration and may also serve to amplify the aggressive gaping display as observed in other fishes.
Technology caregiver intervention for Alzheimer's disease (I‐CARE): Feasibility and preliminary efficacy of Brain CareNotes
Authors: Rodriguez Miriam Jocelyn , Kercher Vanessa Martinez , Jordan Evan J. , Savoy April , Hill Jordan R. , Werner Nicole , Owora Arthur , Castelluccio Pete , Boustani Malaz A. , Holden Richard J. 
Published: September 2023

AbstractBackgroundThe primary aim of the current pilot study was to examine enrollment rate, data completion, usability, acceptance and use of a mobile telehealth application, Brain CareNotes. A secondary aim was to estimate the application's effect in reducing caregiver burden and behavioral and psychological symptoms related to dementia (BPSD).MethodsPatient‐caregiver dyads (n = 53) were recruited and randomized to intervention and control groups. Assessment of usability, acceptance, BPSD symptoms, and caregiver burden were collected at baseline, 3‐ and 6‐month follow‐up.ResultsThe enrollment rate was acceptable despite pandemic related challenges (53/60 target recruitment sample). Among randomized individuals, there was a retention rate of 85% and data completion was attained for 81.5% of those allocated to usual care and 88.5% of those allocated to Brain CareNotes. Mean caregiver‐reported app usability at 6 months was 72.5 (IQR 70.0–90.0) on the System Usability Scale—considered “Good to Excellent”—and user acceptance was reasonable as indicated by 85%–90% of caregivers reporting they would intend to use the app to some degree in the next 6 months, if able. Regarding intervention effect, although differences in outcome measures between the groups were not statistically significant, compared to baseline, we found a reduction of caregiver burden (NPI‐Caregiver Distress) of 1.0 at 3 months and 0.7 at 6 months for those in the intervention group. BPSD (NPI Total Score) was also reduced from baseline by 4.0 at 3 months and by 0.5 at 6 months.ConclusionsBrain CareNotes is a highly scalable, usable and acceptable mobile caregiver intervention. Future studies should focus on testing Brain CareNotes on a larger sample size to examine efficacy of reducing caregiver burden and BPSD.
Incorporation of antimony‐bearing mining wastes into clinker Portland raw feed: The difficulty of Sb analysis in calcium silicates
Authors: Chedrewih Migueli , Thiery Vincent , Gauthier Arnaud , Amin Fouad 
Published: September 2023

AbstractWithin the global trend to valorise various mineral wastes as substituents in Portland cement clinker raw feed, mining wastes are promising candidates. However, they might still contain high levels of metallic elements. Their fate in the kiln is not always understood as well as their incorporation within the various clinker's phases. This is especially the case for antimony. Its in situ microanalysis by the means of energy‐dispersive spectroscopy is tricky since several of its L lines (Lα1 = 3604,72 eV, Lα2 = 3595,32 eV) overlap with calcium lines (Kα1 = 3691,68 eV, Kα2 = 3688,09 eV). Hence, at low concentrations, it is not possible to visualise its characteristics peaks. Increasing the counting rate by increasing the acceleration current results in the generation of spurious sum peaks, rendering the analysis not viable. Wavelength dispersive spectroscopy (i.e. electron microprobe) allows a better spectral resolution and quantification of Sb in the clinker phases. In a Portland cement clinker doped with 1% of Sb‐bearing mining waste, the Sb2O3 content in belite and alite is in the 0.2–0.4 wt.% range as well as for C3A; in C4AF the content is higher, from 1.4 wt.% to 2 wt.%. However, there are microstructural evidence that Sb forms blebs from less than 1 μm in diameter up to 10 μm, included in calcium silicates. Hence, its incorporation in the lattice of calcium silicates is dubious. However, for ferrites and aluminates there is no microstructural evidence for remaining Sb‐bearing phases, suggesting a direct incorporation in crystal lattices.
The efficacy of intradermal hyaluronic acid filler as a skin quality booster: A prospective, single‐center, single‐arm pilot study
Authors: Lee Joo Hee , Kim Jemin , Lee Yun Na , Choi Sooyeon , Lee Young In , Suk Jangmi , Lee Ju Hee 
Published: September 2023

AbstractBackgroundThe use of “skin boosters” comprised of hyaluronic acid (HA)‐based fillers to improve skin quality has gained popularity recently, especially in individuals interested in skin rejuvenation.AimThis study aimed to evaluate the efficacy and safety of intradermal micropuncture injections of HA‐based gel filler combined with lidocaine (BYRYZN® SKINBOOSTER HA, ACROSS Co., Ltd., Gangwon‐do, Korea).Patients/MethodsA prospective, single‐arm, open‐label pilot study was conducted with study subjects who were aged between 30 and 60 years old and exhibited evidence of skin aging, such as wrinkles and loss of elasticity. They received three injections at 2‐week intervals and were followed up for a total of 12 weeks.ResultsTwenty subjects with a mean age of 54.1 years were included. The mean Lemperle wrinkle scale demonstrated a 40% decrease from 2.60 ± 0.60 at baseline to 1.55 ± 0.51 at week 8. The improvement rate was maintained at about 33% until week 12. The average maximum height of the wrinkle (Rz, μm), average skin roughness (Ra, μm), skin elasticity (R2, AU), facial curved length (mm), skin pore size (mm2), skin hydration (AU), TEWL (g/hm2), and skin glossiness (gloss value, AU) exhibited statistically significant improvements over time compared with the baseline measurements. No serious adverse effects or persistent adverse effects were reported, except for a transient subcutaneous nodule in one subject.ConclusionsThis study demonstrates that multiple microinjections of HA‐based gel filler for facial skin aging are safe and effective in improving facial skin quality.
The role of the sleep K‐complex on the conversion from mild cognitive impairment to Alzheimer's disease
Authors: Gorgoni Maurizio , Cenani Jessica , Scarpelli Serena , D'Atri Aurora , Alfonsi Valentina , Annarumma Ludovica , Pietrogiacomi Francesco , Ferrara Michele , Marra Camillo , Rossini Paolo Maria , De Gennaro Luigi 
Published: September 2023

SummaryThe present literature points to an alteration of the human K‐complex during non‐rapid eye movement sleep in Alzheimer's disease. Nevertheless, the few findings on the K‐complex changes in mild cognitive impairment and their possible predictive role on the Alzheimer's disease conversion show mixed findings, lack of replication, and a main interest for the frontal region. The aim of the present study was to assess K‐complex measures in amnesic mild cognitive impairment subsequently converted in Alzheimer's disease over different cortical regions, comparing them with healthy controls and stable amnesic mild cognitive impairment. We assessed baseline K‐complex density, amplitude, area under the curve and overnight changes in frontal, central and parietal midline derivations of 12 amnesic mild cognitive impairment subsequently converted in Alzheimer's disease, 12 stable amnesic mild cognitive impairment and 12 healthy controls. We also assessed delta electroencephalogram power, to determine if K‐complex alterations in amnesic mild cognitive impairment occur with modification of the electroencephalogram power in the frequency range of the slow‐wave activity. We found a reduced parietal K‐complex density in amnesic mild cognitive impairment subsequently converted in Alzheimer's disease compared with stable amnesic mild cognitive impairment and healthy controls, without changes in K‐complex morphology and overnight modulation. Both amnesic mild cognitive impairment groups showed decreased slow‐wave sleep percentage compared with healthy controls. No differences between groups were observed in slow‐wave activity power. Our findings suggest that K‐complex alterations in mild cognitive impairment may be observed earlier in parietal regions, likely mirroring the topographical progression of Alzheimer's disease‐related brain pathology, and express a frontal predominance only in a full‐blown phase of Alzheimer's disease. Consistently with previous results, such K‐complex modification occurs in the absence of significant electroencephalogram power changes in the slow oscillations range.
Oral processing, rheology, and mechanical response: Relations in a two‐phase food model with anisotropic compounds
Authors: Oppen Dominic , Weiss Jochen 
Published: September 2023

AbstractFood‐material poses a challenging matrix for objective material scientific description that matches the consumers' perception. With eyes on the emerging structured food materials from alternative protein sources, objectively describing perceived texture characteristics became a topic of interest to the food industry. This work made use of the well‐known methodologies of jaw tracking and electromyography from the field of “food oral processing" and compared outcomes with mechanical responses to the deformation of model food systems to meat alternatives. To enable transferability to meat alternative products, an anisotropic structuring ingredient for alternative products, high‐moisture texturized vegetable protein (HM‐TVP), was embedded in an isotropic hydrocolloid gel. Data of the jaw movement and muscle activities exerted during mastication were modeled in a linear mixed model and set in relation to characteristic values obtained from small‐ and large‐strain deformation. For improvement of the model fit, this work makes use of two new data‐processing strategies in the field of oral processing: (i) Muscle activity data were set in relation to true forces and (ii) measured data were standardized and subjected to dimensional reduction. Based on that, model terms showed decreased p‐values on various oral processing features. As a key outcome, it could be shown that an anisotropic structured phase induces more lateral jaw movement than isotropic samples, as was shown in meat model systems.
Paved with good intentions: How our systems intersect to create health disparities for multiply marginalized youth
Authors: Ros Anna Maria , Coyne Claire A. , Clarke Stephanie 
Published: September 2023

AbstractBackgroundYouth who hold multiply marginalized identities often experience barriers in accessing care following psychiatric hospitalizationMethodologyThe following commentary piece shares a case amalgamation from a multidisciplinary gender clinic in a tertiary care children's hospital which illustrates the myriad of ways that our current mental healthcare systems fail to connect youth efficiently and effectively to the evidence‐based, culturally relevant, and affirming care that they require, particularly youth experiencing overlapping systems of discrimination and disadvantage.ConclusionsThis piece highlights the inaccessibility of dialectical behavior therapy for multiply marginalized youth, and outlines suggestions for improving access to high‐quality care for minoritized youth engaging in suicidal behavior.
Efficacy and toxicity of carboplatin in the treatment of macroscopic mesenchymal neoplasia in dogs
Authors: Pritchard Céleste , Al‐Nadaf Sami , Rebhun Robert B. , Willcox Jennifer L. , Skorupski Katherine A. , Lejeune Amandine 
Published: September 2023

AbstractPalliative chemotherapy options for dogs with macroscopic non‐osseous mesenchymal tumours are limited. The purpose of this study was to assess the response rate of these tumours to carboplatin chemotherapy. Medical records of 28 dogs treated with carboplatin for macroscopic mesenchymal neoplasia between 1990 and 2022 were retrospectively reviewed. Sixteen dogs with soft tissue sarcoma and 12 dogs with haemangiosarcoma were included. Responses observed included one complete response and three partial responses, for an overall response rate of 14.2% (4/28) and median time to progression of 42 days (range 21–259 days). Responses were only seen in patients with haemangiosarcoma, for a response rate of 33.3% (4/12) and median time to progression for responders of 103 days (range 39–252 days). Median time to progression for dogs with metastatic disease was similar to those with only local disease (distant median: 44 days; local median: 23 days,p = 0.56). Dogs with chemotherapy‐naïve disease were compared to dogs having received previous chemotherapy treatment and had a median time to progression of 75 days and 40.5 days respectively (p = 0.13). Twenty‐two dogs experienced 48 adverse events, with most being grade 1 or 2 (79%). Carboplatin was well tolerated, with variable macroscopic anti‐tumour activity and short response duration. Carboplatin may be an acceptable rescue option for dogs with macroscopic haemangiosarcoma, especially those patients that cannot receive doxorubicin.
Accuracy, precision, and interobserver and intraobserver agreements related to pressure‐measurement devices
Authors: Chen Carolyn L. , Wallace Mandy L. , Reed Rachel A. , Grimes Janet A. 
Published: September 2023

AbstractObjectiveTo evaluate the accuracy, precision, and observer agreement of three pressure measurement devices.Study DesignIn vitro model study.Sample PopulationWater manometer with built‐in gauge (WMg), arterial pressure transducer (APT), and Compass CT (CCT).MethodsThe model was set to five predetermined pressures (4, 8, 13, 17, and 24 cm H2O) using a water manometer with a ruler (WMr) as the gold standard. Each device was tested at each pressure in a randomized order by three investigators. Bland–Altman plots were used to assess agreement between devices. Intraclass correlation coefficients (ICC) were calculated for interobserver and intraobserver agreements.ResultsThe mean differences (cm H2O) ± SEM in comparison with the set pressure were −0.020 ± 0.010 (WMg), −0.390 ± 0.077 (APT), and −1.267 ± 0.213 (CCT). Pressures measured by WMg did not differ from those measured by WMr. Pressures measured by all devices did not differ from each other (p > .062 for all comparisons). Interobserver agreement was excellent (1.000), and intraobserver agreement was excellent (0.985, 0.990, 0.998 for each observer).ConclusionCompared to the WMr, the WMg was the most accurate and precise, followed by the APT; the CCT was the least accurate and precise. Interobserver and intraobserver agreements for all three devices were excellent.Clinical SignificanceThe largest mean difference of all devices was within 1.3 cm H2O of the set pressure, indicating possible clinical utility of any of the devices. However, WMr or WMg should be considered first due to their high precision and accuracy.
Biosynthetic gene cluster signature profiles of pathogenic Gram-negative bacteria isolated from Egyptian clinical settings
Authors: Abdelsalam Nehal Adel , Elhadidy Mohamed , Saif Nehal A. , Elsayed Salma W. , Mouftah Shaimaa F. , Sayed Ahmed A. , Ziko Laila 
Published: September 2023

ABSTRACT

Biosynthetic gene clusters (BGCs) are a subset of consecutive genes present within a variety of organisms to produce specialized metabolites (SMs). These SMs are becoming a cornerstone to produce multiple medications including antibacterial and anticancer agents. Natural products (NPs) also play a pivotal role in enhancing the virulence of ESKAPE pathogens (
Enterococcus faecium
,
Staphylococcus aureus
,
Klebsiella pneumoniae
,
Acinetobacter baumannii
,
Pseudomonas aeruginosa
, and
Enterobacter
spp.), which represent a global health threat. We aimed to sequence and computationally analyze the BGCs present in 66 strains pertaining to three different ESKAPE pathogenic species: 21
A. baumannii
, 28
K. pneumoniae
, and 17
P. aeruginosa
strains recovered from clinical settings in Egypt. DNA was extracted using QIAamp DNA Mini kit and Illumina NextSeq 550 was used for whole-genome sequencing. The sequences were quality-filtered by fastp and assembled by Unicycler. BGCs were detected by antiSMASH, BAGEL, GECCO, and PRISM, and aligned using Clinker. The highest abundance of BGCs was detected in
P. aeruginosa
(590), then
K. pneumoniae
(146) and the least in
A. baumannii
strains (133).
P. aeruginosa
isolates shared mostly the non-ribosomal peptide synthase (NRPS) type,
K. pneumoniae
isolates shared the ribosomally synthesized and post-translationally modified peptide-like (RiPP-like) type, while
A. baumannii
isolates shared the siderophore type. Most of the isolates harbored non-ribosomal peptide (NRP) BGCs with few
K. pneumoniae
isolates encoding polyketide BGCs. Sactipeptides and bottromycin BGCs were the most frequently detected RiPP clusters. We hypothesize that each species’ BGC signature confers its virulence. Future experiments will link the detected clusters with their species and determine whether the encoded SMs are produced and cause their virulence.

IMPORTANCE

Our study analyzes the biosynthetic gene clusters (BGCs) present in 66 assemblies from clinical ESKAPE pathogen isolates pertaining to
Acinetobacter baumannii
,
Klebsiella pneumoniae
, and
Pseudomonas aeruginosa
strains. We report their sequencing and assembly followed by the analysis of their BGCs using several bioinformatics tools. We then focused on the most abundant BGC type in each species and we discussed their potential roles in the virulence of each species. This study is pivotal to further build on its experimental work that deciphers the role in virulence, possible antibacterial effects, and characterization of the encoded specialized metabolites (SMs). The study highlights the importance of studying the “harmful” BGCs and understanding the pathogenicity and virulence of those species, as well as possible benefits if the SMs were used as antibacterial agents. This could be the first study of its kind from Egypt and would shed light on BGCs from ESKAPE pathogens from Egypt.
The Catalog of Resolved Spectroscopic Binaries: Development and Description
Authors: Zeleke D. B. , Pakhomova P. V. , Tessema S. B. , Negu S. H. , Malkov O. Yu. 
Published: September 2023

Abstract
Resolved spectroscopic binaries are unique among other types of binaries. They provide the only possibility (aside from trigonometric parallaxes) to accurately determine distances to objects, which is one of the most important characteristics in astronomy. Such binaries are not numerous, but an exhaustive catalog of them still does not exist. The authors have developed a pilot version of a new catalog of resolved spectroscopic binaries. It contains information about orbital elements, component masses, parallaxes, and other parameters for 107 stars. Thus, the catalog represents the most extensive list of resolved spectroscopic binaries known to date. A preliminary analysis of the distributions of the stellar parameters of the objects in the catalog has been carried out, as well as a comparison of the trigonometric parallaxes from Gaia DR3 with the orbital parallaxes. The article is partly based on a report presented at the conference “Modern Stellar Astronomy-2022,” which was held at the Caucasian Mountain Observatory of the Astronomical institute of Lomonosov Moscow State University on November 8–10, 2022.