bluuebunny/crossref_metadata_2025_split huggingface dataset:
Observational study of pimecrolimus 1% cream for prevention of transcutaneous sensitization in children with atopic dermatitis during their first year of life
Authors: Murashkin Nikolay N. , Namazova-Baranova Leyla S. , Makarova Svetlana G. , Ivanov Roman A. , Grigorev Stepan G. , Fedorov Dmitri V. , Ambarchian Eduard T. , Epishev Roman V. , Materikin Alexander I. , Opryatin Leonid A. , Savelova Alena A. 
Published: April 2023

IntroductionEpidermal barrier dysfunction in children with atopic dermatitis can cause transcutaneous sensitization to allergens and allergic diseases. We evaluated the effectiveness of an early-intervention algorithm for atopic dermatitis treatment, utilizing pimecrolimus for long-term maintenance therapy, in reducing transcutaneous sensitization in infants.MethodThis was a single-center cohort observational study that enrolled children aged 1-4 months with family history of allergic diseases, moderate-to-severe atopic dermatitis, and sensitization to ≥ 1 of the investigated allergens. Patients who sought medical attention at atopic dermatitis onset (within 10 days) were group 1 “baseline therapy with topical glucocorticoids with subsequent transition to pimecrolimus as maintenance therapy”; patients who sought medical attention later were group 2 “baseline and maintenance therapy with topical glucocorticoids, without subsequent use of pimecrolimus”. Sensitization class and level of allergen-specific immunoglobulin E were determined at baseline, and 6 and 12 months of age. Atopic dermatitis severity was evaluated using the Eczema Area and Severity Index score at baseline and 6, 9 and 12 months of age.ResultsFifty-six and 52 patients were enrolled in groups 1 and 2, respectively. Compared with group 2, group 1 demonstrated a lower level of sensitization to cow's milk protein, egg white and house dust mite allergen at 6 and 12 months of age, and a more pronounced decrease in atopic dermatitis severity at 6, 9 and 12 months of age. No adverse events occurred.DiscussionThe pimecrolimus-containing algorithm was effective in treating atopic dermatitis and prophylaxis of early forms of allergic diseases in infants.Trial registrationhttps://clinicaltrials.gov/NCT04900948, retrospectively registered, 25 May 2021.
Evaluation of the impact of pharmaceutical trainings and tools on the proper use of medicines in pediatrics
Authors: Charles F. , Castet-Nicolas A. , Amouroux C. , Moreau J. , Werner O. , Morin D. , Berland P. , Fila M. , de Barry G. 
Published: April 2023

Introduction: After six years of medication errors’ (MEs) collection and analysis in a pediatric unit of a French University Hospital, the number of MEs was no longer decreasing. We then decided to set up pharmaceutical training and tools and evaluate their impact on the occurrence of ME.Materials and methods: This monocentric prospective study was carried out in the form of audits of prescriptions, preparations, and administrations before and after intervention (A1 and A2). After the analysis of A1 results, feedback was given to the teams, some tools for the proper use of medication (PUM) were distributed, and A2 was conducted. Finally, A1 and A2 results were compared.Results: Each audit included 202 observations. A total of 120 MEs were identified during A1 and 54 for A2 (p &lt; 0.0001). The observation rate with at least 1 ME decreased from 39.11% to 21.29% (p &lt; 0.0001), and no observation had more than two MEs during A2 in contrast to A1 (n = 12). Human factors were responsible for the majority of MEs. The audit feedback allowed professionals to feel concerned about ME. The PUM tools received an average satisfaction rating of 9/10. The staff had never participated in this type of training, and all felt it was useful to apply PUM.Conclusion: This study showed a significant impact of pharmaceutical training and tools on the pediatric PUM. Clinical pharmaceutic actions allowed us to reach our objectives and satisfied all the staff. They must, therefore, be continued to limit human factors’ impact and thus contribute to the safety of drug management in pediatrics.
Ubiquitin-proteasome system-based signature to predict the prognosis and drug sensitivity of hepatocellular carcinoma
Authors: Zhang Jianxiang , Liu Liwen , Wang Zenghan , Hou Mingyang , Dong Zihui , Yu Jia , Sun Ranran , Cui Guangying 
Published: April 2023

Background: Ubiquitin-proteasome system (UPS) is implicated in cancer occurrence and progression. Targeting UPS is emerging as a promising therapeutic target for cancer treatment. Nevertheless, the clinical significance of UPS in hepatocellular carcinoma (HCC) has not been entirely elucidated.Methods: Differentially expressed UPS genes (DEUPS) were screened from LIHC-TCGA datasets. The least absolute shrinkage and selection operator (LASSO) and stepwise multivariate regression analysis were conducted to establish a UPS-based prognostic risk model. The robustness of the risk model was further validated in HCCDB18, GSE14520, and GSE76427 cohorts. Subsequently, immune features, clinicopathologic characteristics, enrichment pathways, and anti-tumor drug sensitivity of the model were further evaluated. Moreover, a nomogram was established to improve the predictive ability of the risk model.Results: Seven UPS-based signatures (ATG10, FBXL7, IPP, MEX3A, SOCS2, TRIM54, and PSMD9) were developed for the prognostic risk model. Individuals with HCC with high-risk scores presented a more dismal prognosis than those with low-risk scores. Moreover, larger tumor size, advanced TNM stage, and tumor grade were observed in the high-risk group. Additionally, cell cycle, ubiquitin-mediated proteolysis, and DNA repair pathways were intimately linked to the risk score. In addition, obvious immune cell infiltration and sensitive drug response were identified in low-risk patients. Furthermore, both nomogram and risk score showed a significant prognosis-predictive ability.Conclusion: Overall, we established a novel UPS-based prognostic risk model in HCC. Our results will facilitate a deep understanding of the functional role of UPS-based signature in HCC and provide a reliable prediction of clinical outcomes and anti-tumor drug responses for patients with HCC.
Effect of fungicidal contamination on survival, morphology, and cellular immunity of Apis mellifera (Hymenoptera: Apidae)
Authors: Kaur Gurleen , Singh Amandeep , Sharma Rohit , Thakur Abhinay , Tuteja Shushant , Shyamli  , Singh Randeep 
Published: April 2023

Pesticide residues have been reported in hive-stored products for long periods. Larvae of honey bees experience oral or contact exposure to these products during their normal growth and development inside the cells. We analyzed various toxicological, morphogenic, and immunological effects of residue-based concentrations of two fungicides, captan and difenoconazole, on the larvae of worker honey bees, Apis mellifera. Selected concentrations (0.08, 0.4, 2, 10, and 50 ppm) of both fungicides were applied topically at a volume of 1 µL/larva/cell as single and multiple exposures. Our results revealed a continuous, concentration-dependent decrease in brood survival after 24 h of treatment to the capping and emergence stages. Compared to larvae with a single exposure, the multiply exposed youngest larvae were most sensitive to fungicidal toxicity. The larvae that survived higher concentrations, especially multiple exposures, showed several morphological defects at the adult stage. Moreover, difenoconazole-treated larvae showed a significantly decreased number of granulocytes after 1 h of treatment followed by an increase after 24 h of treatment. Thus, fungicidal contamination poses a great risk as the tested concentrations showed adverse effects on the survival, morphology, and immunity of larval honey bees.
The effects of adverse childhood experiences on depression and suicidal behaviors are partially mediated by neuroticism: A subclinical manifestation of major depression
Authors: Jirakran Ketsupar , Vasupanrajit Asara , Tunvirachaisakul Chavit , Maes Michael 
Published: April 2023

IntroductionNeuroticism, a personality trait, can predict major depressive disorder (MDD). The current study aims to determine whether a) neuroticism is a feature of the acute state of MDD, including suicidal behaviors (SB); and b) adverse childhood experiences (ACEs) are associated with neuroticism in MDD.MethodsThis study included 133 participants, 67 healthy controls and 66 MDD patients, and assessed the Big 5 Inventory (BFI), ACEs using the ACE Questionnaire, and the phenome of depression using the Hamilton Depression Rating Scale (HAM-D), Beck Depression Inventory (BDI), The State-Trait Anxiety Inventory (STAI) and Columbia Suicide Severity Rating Scale (C-SSRS) scores to assess current SB.ResultsNeuroticism was significantly higher in MDD than controls, and it explained 64.9% of the variance in the depression phenome (a latent vector extracted from HAM-D, BDI, STAI, and current SB scores). The other BFI domains had much less (extraversion, agreeableness) or no effect (openness, conscientiousness). One latent vector could be extracted from the phenome, lifetime dysthymia, lifetime anxiety disorders and neuroticism scores. Neglect (physical and emotional) and abuse (physical, neglect and sexual) account for approximately 30% of the variance in this latent vector. Partial Least Squares analysis showed that the effects of neglect on the phenome were partially mediated by neuroticism, whereas the effects of abuse were completely mediated by neuroticism.DiscussionNeuroticism (trait) and the MDD phenome (state) are both manifestations of the same latent core, with neuroticism being a subclinical manifestation of MDD.
The relationship between physical activity and depression among community-dwelling adults in Wuhan, China
Authors: Wu Kai-Ge , Chen Si-Jing , Hu Ya-Ni , Mei Shu-Fang , Chen Wen-Cai , Huang Xian-E , Xu Zai-Feng , Li Ming-Chao , Zhong Bao-Liang , Liu Xiu-Jun 
Published: April 2023

BackgroundWhile the association between physical activity (PA) and depression has been established, there is limited research on the effect of PA on the risk of depression among Chinese individuals. Thus, this study aimed to investigate the relationship between PA and depression among Chinese individuals.MethodsWe used a stratified random sampling approach to recruit participants from five urban districts in Wuhan, China. A total of 5,583 permanent residents aged 18 years or older completed questionnaires, which included the International Physical Activity Questionnaire Short Form (IPAQ-SF) to measure PA, and the 9-item Patient Health Questionnaire (PHQ-9) to evaluate depressive symptoms. To control for potential confounders, multiple logistic regression was employed to assess the association of PA with depression.ResultsThe depression group had significantly lower weekly PA levels, measured in metabolic equivalent of task-minutes per week (MET-min/w), compared to the non-depression group [1,770 (693–4,200) MET-min/w vs. 2,772 (1,324–4,893) MET-min/w, p &lt; 0.001]. In the fully adjusted model, the moderate and high PA level groups had lower odds ratios (ORs) for depressive symptoms compared to the low PA level group [OR (95% confidence interval (CI)) = 0.670 (0.523–0.858), 0.618 (0.484–0.790), respectively]. Among males, moderate and high levels of PA were associated with lower risk of depression compared to low PA levels [OR (95% CI) = 0.417 (0.268–0.649), 0.381 (0.244–0.593), respectively]. However, this association was not observed in females [OR (95% CI) = 0.827 (0.610–1.121), 0.782 (0.579–1.056), respectively]. The study found a significant interaction between PA levels and gender in relation to depression (P for interaction = 0.019).ConclusionThe findings suggest a negative association between PA and risk of depressive symptoms, indicating that moderate to high levels of PA may serve as a protective factor against depressive symptoms.
Recommendations to overcome barriers to the use of artificial intelligence-driven evidence in health technology assessment
Authors: Zemplényi Antal , Tachkov Konstantin , Balkanyi Laszlo , Németh Bertalan , Petykó Zsuzsanna Ida , Petrova Guenka , Czech Marcin , Dawoud Dalia , Goettsch Wim , Gutierrez Ibarluzea Inaki , Hren Rok , Knies Saskia , Lorenzovici László , Maravic Zorana , Piniazhko Oresta , Savova Alexandra , Manova Manoela , Tesar Tomas , Zerovnik Spela , Kaló Zoltán 
Published: April 2023

BackgroundArtificial intelligence (AI) has attracted much attention because of its enormous potential in healthcare, but uptake has been slow. There are substantial barriers that challenge health technology assessment (HTA) professionals to use AI-generated evidence for decision-making from large real-world databases (e.g., based on claims data). As part of the European Commission-funded HTx H2020 (Next Generation Health Technology Assessment) project, we aimed to put forward recommendations to support healthcare decision-makers in integrating AI into the HTA processes. The barriers, addressed by the paper, are particularly focusing on Central and Eastern European (CEE) countries, where the implementation of HTA and access to health databases lag behind Western European countries.MethodsWe constructed a survey to rank the barriers to using AI for HTA purposes, completed by respondents from CEE jurisdictions with expertise in HTA. Using the results, two members of the HTx consortium from CEE developed recommendations on the most critical barriers. Then these recommendations were discussed in a workshop by a wider group of experts, including HTA and reimbursement decision-makers from both CEE countries and Western European countries, and summarized in a consensus report.ResultsRecommendations have been developed to address the top 15 barriers in areas of (1) human factor-related barriers, focusing on educating HTA doers and users, establishing collaborations and best practice sharing; (2) regulatory and policy-related barriers, proposing increasing awareness and political commitment and improving the management of sensitive information for AI use; (3) data-related barriers, suggesting enhancing standardization and collaboration with data networks, managing missing and unstructured data, using analytical and statistical approaches to address bias, using quality assessment tools and quality standards, improving reporting, and developing better conditions for the use of data; and (4) technological barriers, suggesting sustainable development of AI infrastructure.ConclusionIn the field of HTA, the great potential of AI to support evidence generation and evaluation has not yet been sufficiently explored and realized. Raising awareness of the intended and unintended consequences of AI-based methods and encouraging political commitment from policymakers is necessary to upgrade the regulatory and infrastructural environment and knowledge base required to integrate AI into HTA-based decision-making processes better.
Circadian rhythms in pediatric craniopharyngioma
Authors: Kamara Dana , Crowley Stephanie J. , Crabtree Valerie McLaughlin , Hancock Donna , Li Yimei , Darji Himani , Semko Joshua , Wise Merrill S. , Merchant Thomas E. , Mandrell Belinda N. 
Published: April 2023

IntroductionCraniopharyngioma is a brain tumor arising in the region of the hypothalamic-pituitary axis. Children and adolescents with craniopharyngioma have high survival rates, but often experience significant morbidity, including high rates of sleep disorders. Vulnerabilities to circadian disruption are present in this population, but little is known about circadian health.MethodsWe present exploratory circadian findings from a prospective trial at a single center. Data presented here are from the baseline timepoint. Fifty-three patients between the ages of 7 and 20 years provided salivary melatonin samples, following surgical resection and prior to completion of proton therapy, when indicated. We estimated dim light melatonin onset (DLMO) and collected additional sleep data from actigraphy, overnight polysomnography, and the multiple sleep latency test.ResultsAlmost half of participants did not have a valid DLMO estimate during the sampling window, with most being above the threshold at the first sample timepoint. Those with greater disease severity variables (greater hypothalamic involvement and the presence of diabetes insipidus) were significantly more likely to have missed DLMO. For those with valid estimates, DLMO timing correlated with BMI and other sleep variables, including mean sleep latency values on the MSLT.DiscussionThese findings suggest that a subset of those with pediatric craniopharyngioma may experience a phase advance and that this may relate to poorer prognostic indicators. Furthermore, circadian timing correlates with other sleep and health factors. Further research with earlier sampling is needed to better understand circadian rhythms in pediatric craniopharyngioma and associations with other health and disease variables.
External Governance, Corporate Governance, Firm Performance and Economic Growth in the UK and India
Authors: Natto Dinah , Mokoaleli-Mokoteli Thabang 
Published: April 2023

This research investigates the connection between corporate governance and firm performance, corporate governance, and economic growth, the moderating effect of external governance on corporate governance and firm performance, and economic growth by using a sample of one hundred companies listed on the National Stock Exchange of India (NSEI), and one hundred companies listed on the London Stock Exchange (LSE) between 2011 and 2020. We construct three governance indices –the Internal Corporate Governance Index (ICGI) based on 100 elements of governance, and the External Governance index (X-GI) based on World Bank Institutional Quality measures. The study uses GMM Dynamic Panel Data to test the hypotheses. Results show that our newly constructed indexes (the ICGI and CCGI) have significant relationships with firm performance (ROE, Tobin’s Q,) and economic growth (growth in GDP) in both the UK and India. Findings also show that external governance negatively moderates the relationship between corporate governance and firm performance, and the relationship between corporate governance and economic growth for India. The case for the UK is different as external governance positively moderates the relationship between corporate governance and firm performance. However, no significant moderating effect is seen between corporate governance and economic growth.
Keywords: Corporate governance, Institutional quality, Firm performance, Economic growth
Traditional female cook’s role at tourist inflow traditional markets in Bogotá
Authors: Beltrán Karen , Mora Jorge 
Published: April 2023

What is the role of female traditional cooks as carriers of culinary knowledge for tourism development in some of the food markets in Bogota? This research analyses the role of the female cook as a carrier of culinary knowledge, determines contributions to gastronomic heritage that allows tourism development and generates resources for tourism use around local gastronomic heritage. Thus, interviews to traditional female cooks were conducted face to face in order to analyse the knowledge they have about Colombian Cuisine, and where they obtain this knowledge from, as well as their perception on gender division of labour on their kitchens. About methodology, a qualitative approach was used, from the action-participation research method with a process that allows a collective learning of their reality.
As a result, traditional cooks are bearers of intangible cultural heritage and are representatives of Colombian cultural identity; most of their culinary knowledge has been obtained in empirical processes due to family tradition or work experience. In conclusion, their role is to keep the recipes intact and teach them to other generations to maintain cultural heritage as living heritage in the gastronomic tourism chain.
الاثار القانونية المترتبة على الاخلال بالعقد الإداري
Authors: الهاشمي رشا 
Published: April 2023

إن الإدارة تبرم نوعين من العقود مدنية وإدارية، وكل منها يخضع لنظام خاص بها، ويتميز العقد الإداري بجملة من السلطات الاستثنائية تجاه المتعاقد من أجل اجباره على تنفيذ التزاماته.
وإن العقود الإدارية تتطلب تنفيذها إمكانية مالية وفنية كبيرة، سيما العقود التي تنصب على المشاريع الاستراتيجية ومنها عقود المقاولات العامة، والتي تقوم على الكفاءة الفنية والجدارة للمتعاقد، وعليه فأن التأخير في تنفيذ الالتزامات العقدية أو الإهمال والتقصير بشكل يخل بما هو متفق عليه. أو اخلال غيره في الأعمال المكلف بها من أخطر صور المخالفة لارتباط العقد الإداري بضمان سير المرفق العام بانتظام وإطراد.
وللإحاطة بذلك نقسم دراستنا إلى مبحثين، نتناول في الأول منها: مفهوم إخلال المتعاقد، وذلك من خلال تعريفه وصوره، أما المبحث الثاني فنخصصهُ لصور الآثار القانونية المترتبة على إخلال المتعاقد في العقد الإداري، ثم نختم بحثنا بخاتمة تتضمن سلسلة من الاستنتاجات والتوصيات.
السياسة الجنائية المعاصرة للمشرع الاتحادي في دولة الإمارات لمواجهة جرائم الزنا
Authors: دقاني خالد 
Published: April 2023

تناولنا في هذا البحث، السياسة الجنائية المعاصرة للمشرع الإماراتي في مواجهة جرائم الزنا، وفقا لاحدث التعديلات بموجب المرسوم بقانون اتحادي رقم 31 لسنة 2021 بشأن الجرائم والعقوبات، حيث تبنّى بموجبه المشرع الاتحادي سياسة جنائية حديثة، محاولاً من خلالها الموازنة بين حماية الحريات العامة للأفراد ـــ ومنها الحرية الجنسية ـــ وبين حماية الروابط الأسرية، من خلال تجريم زنا الزوج أو الزوجة أو من هم تحت الولاية بوصف مواقعة الانثى برضاها بموجب نص المادة 409 من القانون سالف الذكر ، وما يؤكد لنا ذلك تبنِّى المشرع الإماراتي للمفهوم الضيق للمواقعة، بحيث قصر المواقعة على الإيلاج الطبيعي لقضيب الرجل في فرج الأنثى، بالإضافة إلى أنه في المادة 409/1 من قانون الجرائم والعقوبات قد حدد لنا جنس الجاني في هذه الجريمة ، بحيث تكون من ذكر على أنثى، وهو ما يؤكد لنا تبني المشرع الاتحادي للمفهوم الضيق الذي تتحقق به جريمة الزنا، كما اشترط المشرع الاتحادي لقيام جريمتي مواقعة الأنثى أو اللواط بذكر عنصراً مفترضاً لقيام الجريمة ،وهو الرضا بالاتصال الجنسي الغير مشروع من قبل الأنثى أو الذكر ، وفي حال انعدامه فإننا نكون أمام جريمة مواقعة بالإكراه ، بالاضافة لعنصر الرضا اشترط المشرع الاتحادي سن الثامنة عشر للتعبير عن الرضا بخلاف بعض التشريعات الاخرى التي رفعت سن التعبير عن الرضا بسن الحادية والعشرين .
كما ذهب المشرع الاتحادي؛ إلى تغليب المصلحة الخاصة على المصلحة العامة، في المجتمع للعقاب على جريمة مواقعة الأنثى بالرضا، وذلك بتعليق تحريك الدعوى الجزائية فيها على شكوى الزوج او الولي، كما ساوى المشرع الإماراتي في التجريم بين الزوج أو الزَّوجة، حيث تقوم الجريمة وهي مواقعة الأنثى برضاها، سواء ضبط الزوج يواقع انثى برضاها في منزل الزوجية أو خارجه، وبالتالي خرج المشرع الاتحادي من النقد الذي كان موجها للتشريعات التي كانت تشترط لقيام جريمة زنا الزوج ضبط المرأة زوجها متلبسا بالزنا في منزل الزوجية، وحسناً فعل المشرع الاتحادي فيما ذهب إليه.
الحماية الدولية من الأسلحة غير التقليدية
Authors: الجسمي نوف 
Published: April 2023

تعد الحرب أحد الظواهر المصاحبة للجنس البشري منذ القدم، لذا نجد أن العنصر البشري قد تفنن وأتقن استخدام وصناعة الأسلحة وعمل على تطورها من أجل توفير سبل الحماية والوقاية من أي عدوان خارجي من قبل الأعداء، فمع التطورات المتسارعة على تلك الأسلحة قد أدى إلى زيادة خطورتها، لذا نجد أن العالم يحد من استخدامها ومن إنتاجها، لذا تم انعقاد العديد من المعاهدات لنزعها وللحد من انتشارها، وللحفاظ على أمن واستقرار الدول من الأضرار السلبية الناتجة عن الأسلحة غير التقليدية، ومن هذا المنطلق نجد هناك العديد من الجهود الدولية القائمة لمنع نشر الأسلحة غير التقليدية بكافة صورها حفاظا على السلم والأمن الدوليين.
لهذا سوف نتناول في هذا البحث التعريف بالسلاح وبأنواعه وبالنشأة وبالتطورات التي مر بها الإنسان في صناعة الأسلحة غير التقليدية، وكيف سخر الإنسان المواد الطبيعية واستخدمها في الصناعات غير الآدمية، وكيف جعلها مع استخدامه لما تم ابتكاره من التكنولوجيا والتطبيقات الحديثة في إيذاء الجنس البشري ليس فقط، بل أيضا في إيذاء كافة الكائنات الحية الموجودة على سطح الأرض وكذلك البيئة المحيطة به وأخيراً طرق الحماية والوقاية من تلك الأسلحة غير التقليدية.