bluuebunny/crossref_metadata_2025_split huggingface dataset:
Сhronically Administered BDNF Dipeptide Mimetic GSB-106 Prevents the
Depressive-like Behavior and Memory Impairments after Transient Middle
Cerebral Artery Occlusion in Rats
Authors: Gudasheva Tatiana A. , Povarnina Polina Y. , Antipova Tatyana A. , Logvinov Ilya O. , Seredenin Sergey B. 
Published: January 2023

Background:
A dipeptide mimetic of the BDNF loop 4, bis (N-monosuccinyl-L-seryl-L-lysine) hexamethylenediamide, GSB-106, was designed and synthesized by V.V. Zakusov Research Institute of Pharmacology. The compound activated in vitro TrkB, MAPK/ERK, PI3K/AKT, and PLCγ, like full-length BDNF. In vivo, GSB-106 exhibited antidepressant-like, neuroprotective and neuroregenerative properties.
The aim of this work was to study the effects of GSB-106 on depressive-like behavior, cognitive impairments, as well as on hippocampal neuroplasticity in an experimental model of ischemic stroke.

Methods:
Male Wistar rats were subjected to 60 minutes of transient middle cerebral artery occlusion (MCAO). Dipeptide GSB-106 was administered intraperitoneally at a dose of 0.1 mg/kg/day for 21 days after surgery. 30-40 days after MCAO, the depressive-like state in the forced swimming test and memory impairment in the novel object recognition test were assessed. Then, the content of CREB, as a neuroplasticity marker, was assessed in the ipsilateral hippocampus.

Results:
Rats in MCAO group showed depression-like behavior (increase in immobility time in the forced swimming test by 28% compared to sham group), impairments in short-term and long-term memory (decrease in the discrimination index in the novel object recognition test by 70% and 50%, respectively), and a decrease in immunoreactivity to CREB (cAMP response element-binding protein) in the hippocampus by 36% as compared with the sham group. GSB-106 completely prevented the behavior impairments and counteracted the reduction of immunoreactivity to CREB in the hippocampus.

Conclusion:
The BDNF dipeptide mimetic GSB-106 is promising for further development as a drug for the treatment of poststroke neuropsychiatric disorders.
Iodine(III)-Based Hypervalent Iodine Electrophiles in Organic Synthesis
Authors: Sakthivel Kokila , Kole Priyanka B. , Mamgain Ritu , Singh Fateh V. 
Published: January 2023

Abstract:
The chemistry of hypervalent iodine reagents is now developed as an important tool of synthetic organic chemistry. These reagents play a key role in replacing the toxic heavy metal reagent because of their mild reaction condition and environmentally friendly nature. Mainly, these reagents were known for oxidative properties, but the scope of these reagents is not limited to oxidation reactions. In the past two decades, they have been used as versatile electrophiles in various key organic transformations. Recently, the demand for these reagents has increased drastically for green chemistry, mainly due to their application in catalysis. Hypervalent iodine reagents have been successfully used to develop various oxidative transformations such as the oxidation of different organic species, α-functionalization of carbonyl compounds, cyclization reactions, C-H activation reactions, lactonization and oxidative rearrangements. Moreover, the use of these reagents is not limited to general organic reactions but is successfully used to develop several stereoselective transformations by using chiral hypervalent iodine reagents. This review article highlights various acyclic and cyclic reactions where the hypervalent iodine reagents have been used as electrophiles.
A Mild and Rapid Synthesis of 2-aryl Benzimidazoles by using SO42−/ZrO2-TiO2
as a Heterogeneous Catalyst
Authors: Shelke Sushil V. , Dhumal Sambhaji T. , Deshmukh Tejshri R. , Patil Meghshyam K. 
Published: January 2023

Abstract:
Herein, we have reported an efficient synthesis of 2-aryl benzimidazoles by reacting ophenylenediamines
and substituting aromatic aldehydes using SO4
2−/ZrO2-TiO2 as a heterogeneous
catalyst. This methodology is straightforward to obtain 2-aryl benzimidazoles with good to
excellent yields. It has been performed in ethanol as a green solvent. The reported protocol has
some advantages such as a safe and reusable heterogeneous catalyst, without any need for column
chromatography to obtain desired products. The catalyst can be recovered for up to five catalytic
cycles without significant loss in the catalytic activity.
Structure-guided Design and Optimization of small Molecules as Pancreatic
Lipase Inhibitors using Pharmacophore, 3D-QSAR, Molecular Docking,
and Molecular Dynamics Simulation Studies
Authors: Modanwal Shristi , Mulpuru Viswajit , Mishra Nidhi 
Published: January 2023

Background:
Obesity has now become a global issue due to the increase in the population of obese people. It also substantially impacts the individual's social, financial, and psychological well-being, which may contribute to depression. Being overweight induces many metabolic and chronic disorders, urging many researchers to focus on developing the drug for obesity treatment. Pancreatic lipase inhibitors and natural product/compound-derived pancreatic lipase inhibitors have recently received much attention because of their structural variety and low toxicity.

Objective:
This study aimed to build pharmacophores and QSAR for analyzing the necessary structure of pancreatic lipase inhibitors and designing new molecules with the best activity.

Methods:
Ligand-based pharmacophore modeling and Atom-Based 3D-QSAR were carried out using the PHASE module of Schrodinger to determine the critical structural properties necessary for pancreatic lipase (PL) inhibitory activity. A total of 157 phytoconstituents and a standard drug, orlistat, were selected for the present study. Considering the important features of pancreatic lipase inhibition, 15 new molecules were designed and subjected to molecular docking studies and molecular dynamics simulations. The activity of designed molecules was predicted using the Atom-Based QSAR tool of the PHASE module.

Results:
The top docked score molecule is structure-7 with a docking score of -6.094 Kcal/mol, whereas the docking score of orlistat and tristin is -3.80Kcal/mol and -5.63Kcal/mol, respectively.

Conclusion:
The designed molecules have a high docking score and good stability, are in the desirable ADME range and are derived from natural products, so they might be used as lead molecules for anti-obesity drug development.
Enhanced education for adult patients with persistent post-concussion headaches: a randomized controlled trial
Authors: Collett Emily , Wang Tianru , Todd Candice , Dosaj Anil , Baker Andrew , Hunt Cindy 
Published: January 2023

Aim & Patients: We conducted a randomized clinical trial to determine if an e-learning intervention can enhance recovery in adult patients with persistent post-concussion headaches (PPCH). Materials & Methods: The intervention consisted of three e-learning modules administered at baseline, 6 and 12 weeks. Data were collected on symptoms, community integration, quality of life and healthcare utilization at baseline and 12-week follow-up. ANCOVA was conducted to compare changes. Results: No statistically significant difference was observed on symptoms although we observed a trend toward reduced healthcare utilization and improved quality of life in the intervention group. Conclusion: E-learning modules for patients experiencing PPCH warrant further investigation with data on participant compliance and measures focusing on simpler short-term outcomes. Clinical Trial Registration: NCT03391583 ( ClinicalTrials.gov )
Digital-Based Information System of Zakat Management in Indonesia: Strategies for Increasing Revenue in Fiqh Muamalah Perspectives
Authors: Musa Armiadi , Zulfikar Teuku , Khalidin Bismi 
Published: January 2023

This study aims to examine the digital-based zakat management information system and strategies for increasing ZIS fund income from the perspective of muamalah fiqh in NTB and Aceh. This study focuses on using SimBaznas on the loyalty of zakat payments, the cand constraints, and strategies taken to increase zakat payments in the two regions. This is a mixed-method study to obtain more comprehensive, reliable, and objective data. The results showed that the implementation of SimBaznas at Baznas in NTB was only carried out on reporting zakat collection that had been carried out properly, while reports and asset reports had not been well informed in SimBaznas. Meanwhile, in Aceh Province, all SimBaznas features have not been effective. Quantitative analysis shows that the ease of use and availability of facilities and infrastructure does not guarantee a correlation with the implementation of SimBaznas in the two provinces. In addition, the seriousness of the interest of SimBaznas users has an effective effect on the implementation of the system. However, it is certain that the existence of SimBaznas has no significant effect on the loyalty of Muslims in the two provinces. The problem with using SimBaznas is caused by the lack of quantity and quality of IT-based human resources. Therefore, the strategies that can be applied are improving the quality and quantity of SimBaznas IT managers, socializing SimBaznas to the public, encouraging ratifying the law on zakat as a tax deduction, and finalizing the regulation of zakat as PAD in Aceh. Therefore, in the context of fiqh muamalah, Baitul Mal will increasingly contribute to poverty alleviation, economic development, and human resource development in NTB, Aceh, and Indonesia.
The Disparity Of Judge's Verdict On Child Custody Decision In Aceh Sharia Court
Authors: Nasution Adelina , Pagar Pagar , Asmuni Asmuni 
Published: January 2023

This article aims to explain the difference in the judge’s ruling (disparity) related to child custody (hadhānah) in the Aceh Sharia Court. This article is field research with a qualitative approach. The research method used is a normative-empirical law phenomenology that compares several judges' verdicts on hadhānah cases in the Aceh sharia court. In addition, it also describes that although Indonesia has the same Islamic legal product (KHI) but in implementation between one Judge and another can produce a different verdict. The disparity of the judge's decision that occurred in some cases in Aceh began from the legal provision that the child could not choose a father or mother if the condition had not been mumayiz. In the context of age, custody is given to his mother. In fact, there is a problem with a different verdict by KHI, that is the custody given to the father at the first stage and custody back to the mother at the appeal stage in Sharia Court. The results of the study are; First, the disparity of the judge's verdict is a reasonable situation that occurs depending on the explanation of witnesses and the fact-finding in the field. Second, the KHI format is not absolute in deciding the cases, it takes other proof so that the Judge invites expert witnesses to consider the verdict. Third, consideration of the child's mental, environmental, and condition should be a priority to decide on ideal custody.
Analisis Dampak Pengembangan Pariwisata Danau Sipin Terhadap Ekonomi, Sosial dan Lingkungan di Kota Jambi
Authors: Saputra Hendra , Safri Muhammad , Rosyani Rosyani 
Published: January 2023

Dikembangkannya danau sipin sebagai tempat objek wisata baru di Kota Jambi yang terhitung sejak tahun 2017 tentu banyak hal yang menarik perhatian masyarakat Jambi dan sekitarnya untuk datang beramai-ramai berkunjung, hal ini pula sudah barang tentu mampu di manfaatkan oleh masyarakat sekitar sebagai peluang usaha dan kreatifitas yang menghasilkan untuk menambah nilai tambah ekonomi untuk keluarga besar masyarakat asli danau sipin berprofesi sebagai pedagang di pasar Angso duo, pekerja buruh bangunan dan juga pekerambah. Penelitian ini dilakukan untuk mengidentifikasi hubungan dampak sosial dan lingkungan dengan dampak ekonomi pada masyakakat sekitar objek wisata Danau Sipin. Analisis data menggunakan distribusi frekuensi dan korelasi berganda. Dampak sosial yang terjadi pada masyarakat disekiatar objek wisata Danau Sipin tidak begitu signifikan. Dampak sosial hanya pedgaang menjual dagangan dengan harga yang tinggi dan adanya pemaksaan pelayanan parkir
. Dampak lingkungan yang terjadi pada masyarakat disekitar objek wisata Danau Sipin cukup siginifikan yaitu adanya wisatawan dan pedagang yang membuah sampah sembarang tempat dan lingkungan objek wisata yang berish dapat menarik pengunjung. Dampak ekonomi yang terjadi pada masyarakat disekitar objek wisata Danau Sipin yaitu memberikan peluang kesempatan kerja masyarakat sekitar dalam pengelolaan objek wisata, keberadaan onjek wisata meningkatkan taraf hidup masyarakat sekitar, meningkatkan pendapatan pedagang. Berdasarkan hasil analisis korelasi berganda bahwa dampak sosial dan dan dampak lingkungan memiliki hubungan yang sangat kuat dan dignifikan terhadap dampak ekonomi pada masyarakat disekiatar objek wisata Danau Sipin
Analisis Pembentukan Badan Usaha Milik Desa Sebelum Dan Sesudah Di Undangkan Undang-Undang Nomor 11 Tahun 2020 Tentang Cipta Kerja
Authors: Habib Kashogi Iznan , Radjab Dasril , Bustanuddin Bustanuddin 
Published: January 2023

Badan Usaha Milik Desa (BUMDes) diharapkan dapat meningkatkan perekonomiandan pelayanan umum kepada masyarakat di desa. Undang-Undang Nomor 6 Tahun2014 tentang Desa, menyebutkan BUMDes sebagai badan usaha. Badan usaha yangdimaksud tidak ditentukan secara khusus dalam Undang-Undang Desa. Hal inimenimbulkan berbagai masalah dalam pendirian maupun usaha BUMDes dimasyakarat desa. Penelitian ini bertujuan untuk menganalisa status BUMDes sebelumdan sesudah diundangkannya Undang-Undang Nomor 11 Tahun 2020 tentang CiptaKerja, serta implikasinya karena dalam Pasal 117 Undang-Undang Cipta Kerjamengubah Pasal 1 angka 6 Undang-Undang Desa yang sebelumnya menyebutBUMDes sebagai badan usaha diubah menjadi badan hukum. Penelitian inimenggunakan metode penelitian doctrinal research. Sumber bahan hukum yangdigunakan dalam penelitian ini meliputi bahan-bahan hukum primer, bahan-bahanhukum sekunder serta bahan-bahan hukum tersier dan metode analisis yangdigunakan metode analisis dedukatif. Dapat disimpulkan bahwa status BUMDessebelum diundangkannya Undang-Undang Cipta Kerja adalah badan usaha yangberbentuk badan hukum karena BUMDes telah memenuhi karakteristik dari badanhukum. Kemudian status badan hukum BUMDes dipertegas dalam Undang-UndangCipta Kerja yang membuat BUMDes dapat memiliki sifat seperti badan hukum yanglain pada umumnya dan BUMDes dapat disahkan sebagai badan hukum.
Kata Kunci : Pembentukan, BUMDes, Badan Usaha, Badan Hukum
ANALISIS TERHADAP PENGATURAN KEBEBASAN HUKUM BERPENDAPAT MELALUI MEDIA INTERNET
Authors: Dwi Hardiyaningsi Etika , Yarni Meri 
Published: January 2023

This study aims to: 1) To find out how the legal protection of the regulation of freedom of expression through the internet media, 2) To find out how the form of the Indonesian state's obligation to protect the right to freedom of expression on the internet media. The method used in this stkebebudy is the normative juridical method, which is a legal research that is prescriptive not descriptive as in social and natural sciences, the approach is based on the main legal material by examining theories, concepts, legal principles and regulations. legislation. The results obtained are: 1). Freedom of expression in Indonesia, both orally and in writing, has been guaranteed and has been regulated in the rules contained in the 1945 Constitution until it is contained in Law Number 39 of 1999 concerning Human Rights, Law Number 9 of 1998 concerning Freedom to Express Opinions in Public, Law Number 12 of 2005 concerning Ratification of the International Covenant On Civil And Political Rights (International Covenant on Civil and Political Rights), 2) The rights and obligations of the state (government) and citizens are regulated in law - The 1945 Constitution is in the fourth paragraph. and Article 281 paragraphs (4) and (5). The fourth paragraph contains the goals and obligations of the state that must be carried out by every government, namely protecting the entire Indonesian nation and the entire homeland of Indonesia, advancing public welfare, educating the nation's life, and implementing world order based on independence, eternal peace, and social justice.

Keywords; Freedom of Opinion, Internet.
ANALISIS KEWENANGAN BAWASLU KABUPATEN/KOTA DALAM PENYELESAIAN SENGKETA PROSES PEMILIHAN UMUM BERDASARKAN PERATURAN PERUNDANG-UNDANGAN
Authors: Surya Dharma Melia , Syamsir Syamsir , Bustanuddin Bustanuddin 
Published: January 2023

Abstract

Based on Article 99 of Law Number 7 of 2017 concerning General Elections that the authority of Bawaslu is to receive and follow up on reports relating to alleged violations of the implementation of laws and regulations governing elections, examine and review election violations in the province and recommend the results of the examination and review of parties regulated by law. Dispute resolution is a process, method or act of resolving something that causes differences of opinion, disputes or quarrels. Every dispute, whatever happens, always demands a solution and resolution. Based on Law Number 7 of 2017 concerning General Elections, Article 469 Paragraph (1) states that the Bawaslu decision regarding disputes over the General Election process is a final and binding decision. General Election, hereinafter referred to as General Election, is a means of people's sovereignty to elect members of the People's Representative Council, members of the Regional Representatives Council, President and Vice President, and to elect members of the Regional People's Representative Council, which are carried out directly, publicly, freely, confidentially, honestly and fairly. within the unitary State of the Republic of Indonesia based on Pancasila and the 1945 Constitution of the Republic of Indonesia.

Keywords: Authority, Bawaslu, Dispute Resolution, Election

Abstrak
Berdasarkan Pasal 99 Undang-Undang Nomor 7 Tahun 2017 Tentang Pemilihan Umum bahwa kewenangan bawaslu dengan menerima dan menindak lanjuti laporan yang berkaitan dengan dugaan pelanggaran terhadap pelaksanaan peraturan perundang-undangan yang mengatur tentang pemilu, memeriksa dan mengkaji pelanggaran pemilu diwilayah provinsi serta merekomendasikan hasil pemeriksaan dan pengkajian kepada pihak yang diatur dalam undang-undang. Penyelesaian sengketa adalah proses, cara atau perbuatan dalam menyelesaikan sesuatu yang menyebabkan perbedaan pendapat, perselisihan atau pertengkaran. Setiap sengketa apapun yang terjadi, selalu menuntut pemecahan dan penyelesian. Berdasarkan Undang-Undang Nomor 7 Tahun 2017 tentang Pemilihan umum Pasal 469 Ayat (1) Menyebutkan bahwa putusan Bawaslu mengenai sengketa proses Pemilihan Umum merupakan keputusan yang bersifat final dan menginkat. Pemilihan Umum yang selanjutnya disebut Pemilu adalah sarana kedaulatan rakyat untuk memilih anggota Dewan Perwakilan Rakyat, anggota Dewan Perwakilan Daerah, Presiden dan Wakil Presiden, dan untuk memilih anggota Dewan Perwakilan Rakyat Daerah, yang dilaksanakan secara langsung, umum, bebas, rahasia, jujur dan adil dalam Negara kesatuan Republik Indonesia berdasarkan Pancasila dan Undang-Undang Dasar Negara Republik Indonesia Tahun 1945.
Kata kunci: Kewenangan, Bawaslu, Penyelesaian Sengketa, Pemilu
Simplified Meal Announcement Versus Precise Carbohydrate Counting in Adolescents With Type 1 Diabetes Using the MiniMed 780G Advanced Hybrid Closed Loop System: A Randomized Controlled Trial Comparing Glucose Control
Authors: Petrovski Goran , Campbell Judith , Pasha Maheen , Day Emma , Hussain Khalid , Khalifa Amel , van den Heuvel Tim 
Published: January 2023

OBJECTIVEWe aimed to compare glucose control in adolescents with type 1 diabetes (T1D) using the MiniMed 780G system who used simplified meal announcement with those who used precise carbohydrate counting.RESEARCH DESIGN AND METHODSThis randomized controlled trial included 34 participants (age 12–18 years) with T1D who were on multiple daily injections or insulin pump and were scheduled to start using the MiniMed 780G system at Sidra Medicine in Qatar. After a 7-day run-in period, participants were randomly assigned to the fix group (simplified meal announcement by preset of three personalized fixed carbohydrate amounts) or the flex group (precise carbohydrate counting) and followed for 12 weeks. Between-group difference in time in range (TIR) was the primary end point. Secondary end points included HbA1c and other glycometrics.RESULTSDuring the 12-week study phase, TIR was 73.5 ± 6.7% in the fix and 80.3 ± 7.4% in the flex group, with a between-group difference of 6.8% in favor of flex (P = 0.043). Time &gt;250 mg/dL was better in the flex group (P = 0.012), whereas HbA1c (P = 0.168), time below range (P = 0.283), and time between 180 and 250 mg/dL (P = 0.114) did not differ.CONCLUSIONSAdolescents using the MiniMed 780G system with a preset of three personalized fixed carbohydrate amounts can reach international targets of glycemic control. Therefore, it may be a valuable alternative to precise carbohydrate counting in users who are challenged by precise carbohydrate counting. Because carbohydrate counting further improves outcomes, these skills remain important for MiniMed 780G users.
The Implementation Of Digital Audio Workstation Learning In Digital Music At Art Drama, Dance, And Musicstudy Program Of Padang State University
Authors: Hidayat Rian , Syafwandi Syafwandi 
Published: January 2023

This study aimed to determine, describe and analyze the facilities and infrastructure for Digital Music lectures at the Art, Drama, Dance and Music Study Program of UNP, the use of DAW as the primary medium for learning Digital Music at the Art, Drama, Dance and Music Study Program, Universitas Negeri Padang, and the implementation of digital audio workstations in the Digital Music lectures of the Art, Drama, Dance and Music Study Program, Universitas Negeri Padang. This type of research was descriptive qualitative research. The main instrument in this study was the researcher himself and assisted by supporting instruments such as stationery, camera, memory card /flash disk, and mobile phone. This study's data sources were lecturers and students of the Art, Drama, Dance and Music Study Program, Universitas Negeri Padang. The informants of this research are lecturers in Digital Music lectures at the the Art, Drama, Dance and Music Study Program, Universitas Negeri Padang. Data collection techniques were carried out using library research, observation, and interviews. The steps to analyze the data were data collection, data reduction, data presentation, and concluding. The results showed inadequate facilities and infrastructure for digital music lectures. The facilities and infrastructure only use computers and soundcards in digital music lectures.
Meanwhile, the facilities needed in digital music lectures are computers, soundcards, mixers, microphones, and midi controllers. The Sibelius, Nuendo, and fruity loop software were used in this lecture. However, students still expect the provision of software from the lecturer without trying to download the software. The implementation of the classes for this course went well. It was following the RPS used by the lecturer in charge of digital music courses, so the material provided was well conveyed. However, in implementing a Digital Audio Workstation, many students could not operate it properly, whether operating Sibelius, Nuendo, or fruity loop. As music academics, students should at least master notation writing and music editing to have skills in work after graduating from college.