bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tolerability profile of paliperidone palmitate formulations: A pharmacovigilance analysis of the EUDRAVigilance database
Authors: Cicala Giuseppe , de Filippis Renato , Barbieri Maria Antonietta , Cutroneo Paola Maria , De Fazio Pasquale , Schoretsanitis Georgios , Spina Edoardo 
Published: April 2023

IntroductionLong-acting injectable antipsychotics (LAIs) have proven to be effective in the maintenance treatment of patients suffering from schizophrenia, and their safety and tolerability profiles represent a key factor in their long-term use and choice in clinical practice. Paliperidone palmitate (PP) is the only second-generation LAI (SGA-LAI), available in both one- (PP1M) and 3-month (PP3M) formulations. However, real-world prospective studies on PP1M and PP3M are still few and mostly conducted on small samples. In this context, we aimed to better define the safety and tolerability profile of PP using real world pharmacovigilance data.MethodsWe retrospectively analyzed the publicly available data regarding Individual Case Safety Reports (ICSRs), presenting PP1M and/or PP3M as suspected drugs, reported on EUDRAVigilance between 2011 and June 30th, 2022. ICSRs relative to at least one SGA-LAI other than PP, reported between 2003 and June 30th, 2022, were also examined as reference group. Data were evaluated with a descriptive analysis, and then, as disproportionality measures, crude reporting odds ratio (ROR) and 95% confidence interval (CI) were calculated.ResultsA total of 8,152 ICSRs met the inclusion criteria, of those 77.7% (n = 6,332) presented as suspected drug PP1M, 21.2% (n = 1,731) PP3M, while 89 cases indicated both PP1M and PP3M. Significantly higher probabilities of reporting in PP-related reports were observed for the primary Standardized MedDRA Queries “Sexual Dysfunctions” (ROR = 1.45; 95% CI 1.23-1.70), “Haemodynamic oedema, effusions and fluid overload” (ROR = 1.42; 1.18-1.70), as well as “Fertility disorders” (ROR = 2.69; 1.51-4.80).DiscussionOur analysis indicates that the tolerability and safety profiles of PP are in line with what is known for the other SGA-LAIs. However, differences regarding endocrine system ADRs have been noticed. The results presented in this work do not discourage the prescription of SGA-LAI formulations but aim to enhance their safety.
Performance assessment of medical service for organ transplant department based on diagnosis-related groups: A programme incorporating ischemia-free liver transplantation in China
Authors: Lu Jianjun , Lin Zhuochen , Xiong Ying , Pang Hui , Zhang Ye , Xin Ziyi , Li Yuelin , Shen Zhiqing , Chen Wei , Zhang Wujun 
Published: April 2023

BackgroundIn July 2017, the first affiliated hospital of Sun Yat-sen university carried out the world’s first case of ischemia-free liver transplantation (IFLT). This study aimed to evaluate the performance of medical services pre- and post-IFLT implementation in the organ transplant department of this hospital based on diagnosis-related groups, so as to provide a data basis for the clinical practice of the organ transplant specialty.MethodsThe first pages of medical records of inpatients in the organ transplant department from 2016 to 2019 were collected. The China version Diagnosis-related groups (DRGs) were used as a risk adjustment tool to compare the income structure, service availability, service efficiency and service safety of the organ transplant department between the pre- and post-IFLT implementation periods.ResultsIncome structure of the organ transplant department was more optimized in the post-IFLT period compared with that in the pre-IFLT period. Medical service performance parameters of the organ transplant department in the post-IFLT period were better than those in the pre-IFLT period. Specifically, case mix index values were 2.65 and 2.89 in the pre- and post-IFLT periods, respectively (p = 0.173). Proportions of organ transplantation cases were 14.16 and 18.27%, respectively (p &lt; 0.001). Compared with that in the pre-IFLT period, the average postoperative hospital stay of liver transplants decreased by 11.40% (30.17 vs. 26.73 days, p = 0.006), and the average postoperative hospital stay of renal transplants decreased by 7.61% (25.23 vs.23.31 days, p = 0.092). Cost efficiency index decreased significantly compared with that in the pre-IFLT period (p &lt; 0.001), while time efficiency index fluctuated around 0.83 in the pre- and post-IFLT periods (p = 0.725). Moreover, the average postoperative hospital stay of IFLT cases was significantly shorter than that of conventional liver transplant cases (p = 0.001).ConclusionThe application of IFLT technology could contribute to improving the medical service performance of the organ transplant department. Meanwhile, the DRGs tool may help transplant departments to coordinate the future delivery planning of medical service.
Satisfaction with care quality and anxiety among family members during nursing home visiting restrictions: The chain mediating effect of emotional regulation and perceived stress
Authors: Hui Zhaozhao , Wang Xiaoqin , Wang Xun , Zhao Jinping , Pan Yunjin , Liu Feng , Zheng Ruishi , Wang Mingxu 
Published: April 2023

IntroductionThis study aimed to investigate the psychological well-being (perceived stress and anxiety) of Chinese family members during nursing home visiting restrictions and to elucidate the relationships among satisfaction with care quality, emotion regulation, perceived stress, and anxiety.MethodsAn online survey was conducted with a cross-sectional study design. From 18 to 29 January 2022, a total of 571 family members of nursing home residents completed online questionnaires comprising socio-demographic characteristics, satisfaction with care quality, emotion regulation, perceived stress, and anxiety. Mediation analyses were performed to estimate the direct and indirect effects of satisfaction with care quality on anxiety using the PROCESS macro for SPSS.ResultsThe results showed that approximately one-quarter of Chinese family members had anxiety symptoms during nursing home visiting restrictions. Satisfaction with care quality affected anxiety via three mediating paths: (a) through cognitive reappraisal (effect = 0.028); (b) through cognitive reappraisal and perceived stress sequentially (effect = −0.057); and (c) through perceived stress (effect = −0.212). The chain mediating effect (path b) accounted for 23.7% of the total effect.ConclusionsThese findings corroborated our hypothesis that cognitive reappraisal (a kind of emotion regulation strategy) and perceived stress mediated the relationship between satisfaction with care quality and anxiety during nursing home visiting restrictions. Efforts to address family members’ psychological well-being by focusing on cognitive reappraisal should be considered.
A reevaluation of selected mortality risks in the updated NCI/NIOSH acrylonitrile cohort study
Authors: Marsh Gary M. , Kruchten Adam 
Published: April 2023

ObjectivesThe study aimed to determine whether the National Cancer Institute's (NCI) recent suggestion of associations between acrylonitrile (AN) exposure and mortality in lung and bladder cancer and pneumonitis is robust to alternative methods of data analysis.Materials and methodsWe used the Richardson method to indirectly adjust risk ratios (RRs) in relation to AN exposure for potential confounding by smoking and asbestos. We repeated key analyses omitting workers from Plant 4 to account for possible local, historical shipyard-related asbestos exposures.ResultsThe adjustment of lung cancer RRs for confounding by both smoking and asbestos and omitting Plant 4 workers yielded mostly decreased RRs and much less evidence of a positive association with cumulative AN exposure.ConclusionOverall, our reanalysis provided little evidence to support NCI's suggestion of associations between AN exposure and mortality in lung and bladder cancer and pneumonitis.
Perspectives and evaluation on the effect of financial burden relief of medical insurance for people with catastrophic diseases and its influencing factors
Authors: Guo Pengfei , Qin Yinghua , Wang Rizhen , Li Jiacheng , Liu Jingjing , Wang Kexin , Li Ye , Kang Zheng , Hao Yanhua , Liu Huan , Sun Hong , Cui Yu , Shan Linghan , Wu Qunhong 
Published: April 2023

BackgroundCatastrophic disease sufferers face a heavy financial burden and are more likely to fall victim to the “illness-poverty-illness” cycle. Deeper reform of the medical insurance system is urgently required to alleviate the financial burden of individuals with catastrophic diseases.MethodsData were obtained from a cross-sectional questionnaire survey conducted in Heilongjiang in 2021, and logistic regression and restricted cubic spline model was used to predict the core factors related to medical insurance that alleviate the financial burden of people with catastrophic diseases.ResultsOverall, 997 (50.92%) medical insurance-related professionals negatively viewed financial burden relief for people with catastrophic diseases. Factors influencing its effectiveness in relieving the financial burden were: whether or not effective control of omissions from medical insurance coverage (OR = 4.04), fund supervision (OR = 2.47) and degree of participation of stakeholders (OR = 1.91). Besides, the reimbursement standards and the regional and population benefit package gap also played a role. The likelihood of financial burden relief increased by 21 percentage points for each unit increase in the level of stakeholder discourse power in reform.ConclusionChina’s current medical insurance policies have not yet fully addressed the needs of vulnerable populations, especially the need to reduce their financial burden continuously. Future reform should focus on addressing core issues by reducing the uninsured, enhancing the width and depth of medical insurance coverage, improving the level and capacity of medical insurance governance that provides more discourse power for the vulnerable population, and building a more responsive and participatory medical insurance governance system.
C-reactive protein to lymphocyte ratio is a significant predictive factor for poor short-term clinical outcomes of SARS-CoV-2 BA.2.2 patients
Authors: Xiao Benjie , Wu Yinyan , Liang Huazheng , Xiao Jingjing , Han Yudi , Yang Zhangwei , Bi Yong 
Published: April 2023

ObjectiveThe aim of the present study is to assess the utility of C-reactive protein to Lymphocyte Ratio (CLR) in predicting short-term clinical outcomes of patients infected by SARS-CoV-2 BA.2.2.MethodsThis retrospective study was performed on 1,219 patients with laboratory-confirmed SARS-CoV-2 BA.2.2 to determine the association of CLR with short-term clinical outcomes. Independent Chi square test, Rank sum test, and binary logistic regression analysis were performed to calculate mean differences and adjusted odds ratios (aORs) with their 95% CI, respectively.ResultsOver 8% of patients admitted due to SARS-CoV-2 BA.2.2. were critically ill. The best cut-off value of CLR was 21.25 in the ROC with a sensitivity of 72.3% and a specificity of 86%. After adjusting age, gender, and comorbidities, binary logistic regression analysis showed that elevated CLR was an independent risk factor for poor short-term clinical outcomes of COVID-19 patients.ConclusionC-reactive protein to Lymphocyte Ratio is a significant predictive factor for poor short-term clinical outcomes of SARS-CoV-2 BA.2.2 inflicted patients.
Mercury Content and Pools in Complex Polycyclic Soils From a Mountainous Area in Galicia (NW Iberian Peninsula)
Authors: Gómez-Armesto Antía , Méndez-López Melissa , Parente-Sendín Andrea , Calvo-Portela Noemi , Pontevedra-Pombal Xabier , García-Rodeja Eduardo , Alonso-Vega Flora , Nóvoa-Muñoz Juan Carlos 
Published: April 2023

Atmospheric mercury (Hg) usually tends to accumulate in the upper horizons of soils. However, the physico-chemical characteristics of some soils, as well as pedogenetic processes, past climate changes, or soil degradation processes, can lead to a redistribution of mercury through the soil profile. In this work, the presence and accumulation of mercury was studied in three deep polycyclic soils from a mountainous area in NW Iberia Peninsula. The highest total Hg values (HgT) were found in the organic matter-rich O and A horizons of FL and MF profiles (169 and 139 μg kg−1, respectively) and in the illuvial horizon of RV (129.2 μg kg−1), with the latter two samples showing the maximum Hg reservoirs (29.3 and 29.0 mg m−2, respectively). Despite finding the highest Hg content in the surface horizons, considerable Hg reservoirs were also observed in depths higher than 40–50 cm, indicating the importance of taking into account these soil layers when Hg pools are evaluated at a global scale. Based on the mass transfer coefficients, we can rule out the contribution of parent material to the Hg accumulation in most of the horizons, thus indicating that pedogenetic processes are responsible for the Hg redistribution observed along the soil profiles. Finally, by means of principal component analysis (PCA) and stepwise linear regression we could assess the main soil components involved in the Hg accumulation in each soil horizon. Therefore, PC1 (organic matter and low stability Al-hummus complexes) showed a higher influence on the surface horizons, whereas PC2 (reactive Al-Fe complexes and medium-high Al-hummus complexes) and PC4 (crystalline Fe compounds and pHw) were more relevant in the Hg distribution observed in the deepest soil layers.
ДІЯЛЬНІСТЬ МІЛІЦІЇ УРСР У ЛИСТОПАДІ 1941 - СЕРЕДИНІ СІЧНЯ 1942 РОКІВ
Authors: Ярмиш О. , Греченко В. 
Published: April 2023

Досліджуються основні аспекти та напрями діяльності органів міліції в один з найважчих періодів радянсько-німецької війни - кінець 1941 р. – початок 1942 р. Виявлено, що основною проблемою, яка утруднювала діяльність міліції в цей час, був значний некомплект кадрів, особливо серед оперуповноважених та інспекторів. Головна увага в роботі міліції в цей час приділялася протидії бандитизму і дезертирству, виявленню ухильників від мобілізації, боротьбі з мародерами, грабіжниками, крадіями та іншими кримінальними злочинцями, виявлення та притягнення до кримінальної відповідальності спекулянтів та розкрадачів державної власності.
Le dénuement cynique
Authors: Pietra Régine 
Published: April 2023

«The Cynic ’s Nakedness »
It seems to us that, in a general reflection about the nudity, the greek cynics had something to teach us, since they had made denudation their battlehorse both in the literal and in the figurative sense. Their philosophy incites us to strip naked, to allow Nature in its nudity to speak, to do away with all the finery constituted by compliances, social roles, the positions acquired by wealth, the hypocritical attitudes forstered by politeness, to shake off the make believe of usage and morality.
Relying on the texts left us by doxographs and concerning the cynics, we have demonstrated the specificity of their relationship with the body and Nature, specificity which sometimes manifests itself demonstrated by provocative attitudes aimed at destabilization and reflexion. A philosophy of gesture and invective, unconnected with any system, cynicism disquiets and it is precisely this salutary disquiet which explains why it can, to this day, attract us.
“Bien fait, mal fait, pas fait”
Authors: Chiron Eliane 
Published: April 2023

Il sera question, une fois de plus, de Marcel Duchamp alias Rrose Sélavy. Faire, au sens de façonner ou feindre (facere, fingere),
est abordé à partir du Narrateur (Benjamin), qui est là “en personne” avec toute sa vie. On verra, pas à pas, comment Duchamp façonne la matière des mots, tandis que sa main artisanale façonne d’autres matières. La mort réelle de l’artiste est la condition de la réactivation ininterrompue de l’art. L’artiste façonne le temps : à condition de feindre sa mort (à travers Rrose Sélavy) et qu’elle soit en même temps réelle. Marcel Duchamp façonne sa vie et feint sa (re) naissance avec son oeuvre posthume Étant donné… Bien fait, mal fait, pas fait, peu importe : l’artiste “se refait”, comme le joueur à la roulette.
II Plan para la Igualdad de Oportunidades de las Mujeres (1993-1995)
Authors: - - 
Published: April 2023

La realidad social de las mujeres españolas y la respuesta institucional a los desafíos que comporta su creciente participación en el ámbito público se han modificado intensa y profundamente en un corto período de tiempo.
Se ha pasado de la pervivencia de importantes discriminaciones en el ámbito jurídico, a disponer de una legislación que puede considerarse de las más avanzadas de Europa. En este tiempo el tratamiento de la problemática femenina ha evolucionado desde la igualdad de derechos hacia el compromiso institucional de aplicación de políticas de acción positiva.
La preocupación gubernamental por el retraso evidente de las mujeres españolas respecto a su participación social condujo a la puesta en marcha de una serie de medidas políticas de igualdad de oportunidades. A finales de 1983 se creó el Organismo Autónomo Instituto de la Mujer y, en septiembre de 1987, el Gobierno aprobó el primer Plan para la Igualdad de Oportunidades de las Mujeres, elaborado por el Consejo Rector del Instituto de la Mujer. En este Consejo está representada la mayoría de los Departamentos ministeriales, a los cuales se responsabiliza de la ejecución de las medidas del Plan. Se trata de la consolidación de una política de coordinación horizontal, para promover programas y actuaciones que favorezcan la igualdad de oportunidades de las mujeres, desde diferentes Organismos de la Administración.
Glycemic Control Improvement amongst Patients with Diabetes Mellitus during a COVID-19 Lockdown in Jordan
Authors: Nofal Amani , Abu Jabeh Raghed , Alrafayia Dana , Hyasat Tala , Suboh Lojayn , Aljabiri Reyad , Al Ryalat Saif , Alhawari Hussam , Jaber Ruba 
Published: April 2023

Aims: The purpose of this study is to evaluate the effects of lockdown measures by the Jordanian government to contain the spread of the novel corona virus (COVID-19) on glycemic control of patients with diabetes mellitus.
Methods: This cross-sectional study was conducted in Jordan University Hospital. A total of 264 patients with type 2 or type 1 diabetes mellitus were sampled. The authors evaluated the extent of glycemic control reached by patients with type 2 or type 1 diabetes mellitus by measuring change in glycosylated hemoglobin (A1C) values, in addition to the number of hypoglycemic episodes experienced by patients during lockdown. The authors conducted a questionnaire via telephone interviews to record information about drug adherence and availability, diet, physical activity, and telephone consultations. A paired sample t-test was used to compare values before and after lockdown.
Results: A significant reduction in HbA1C values was found during lockdown (p=0.038), with only 33.6% of patients experiencing one or more hypoglycemic episodes; both factors suggest controlled blood glucose levels. Medication adherence was found to be the main reason for improvement, with 74.8% of our population being strongly adherent to their medications.
Conclusions: In Jordanian patients with diabetes mellitus, glycemic control was significantly improved during COVID-19 lockdown and this was found to be associated with strong medication adherence.
The Association between Smartphone Addiction, Depression and Anxiety among Medical Students in Jordan
Authors: Alabdallat Y , Albakri K. A. , Al-Hanaqtah B. M. , Al-Dajani M. H. , Saleh O. M. , Harvey H. 
Published: April 2023

Introduction: Awareness of psychological disorders such as smartphone addiction, anxiety, and depression is a trending research area in the scientific community that has further escalated with the impact of COVID-19. In this regard, young adults and medical students are already considered to be under a high level of stress academically and culturally. This study aimed to investigate the relationship between depression, anxiety, and smartphone addiction among medical students in Jordan.
Methods: A cross-sectional study was conducted using an online structured questionnaire. The survey was completed by 164 male and female medical students stratified by years one to three in the basic medical sciences. The survey consisted of items from the Generalized Anxiety Disorder (GAD-7), Patient Health Questionnaire (PHQ-9), and Smartphone Addiction Scale-Short Version (SAS-SV), in addition to two questions concerning the impact of the COVID-19 pandemic on smartphone addiction.
Results: Among the students who participated, the mean age was 18.9, with almost half (47.2%) being first-year students. The results showed no significant difference in stress, anxiety or cell phone addiction based on gender or academic year. The logistic regression model was not statistically significant regarding the covariates, except for GAD, which had an OR=1.15 (CI: 1.06 -1.25). Furthermore, SAS-SV was positively correlated with GAD-7 and PHQ-9 scores (r=0.42, r=0.2, p< 0.000, p=0.029, respectively).
Conclusions: The results of the study showed a statistically significant positive correlation between smartphone addiction, depression, and anxiety. These variables were not statistically different among medical students in terms of gender and academic year.
Levels of selective oxidative stress markers and antioxidant enzymes in blood of Hubble-Bubble smokers
Authors: Shafagoj Yanal , Al-Qudah Tamara , Al-Essa Mohamed K. , Mustafa Ebtihal , Albdour Suzan , ALkhateeb Mohammed , Naif Karadsheh  , Khatib Faisal , Mohammed Faisal I. 
Published: April 2023

Background: Hubble-Bubble smoking is a common smoking practice and spreading fast among young adults even in western countries. People think it is less toxic than cigarette smoking.
Aim: The aim of this study was to investigate the levels of oxidative stress markers and antioxidants in the blood of Hubble-Bubble (smokers compared to controls as a sign of toxicity, since disease process is caused by abnormal antioxidant capacity.
Methods: Blood samples were collected by authorized personnel from recruited healthy volunteers (28 habitual Hubble-Bubble smokers and 18 nonsmokers). The levels of oxidative stress markers (Malondialdehyde (MDA), and protein carbonyl) and antioxidants superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx)) and lipids were measured.
Results: Protein carbonyl level in HB smokers’ group (2.58 mmol/gm of protein) was significantly higher than in control group (2.58 ±0.8 vs. 2.04 ±0.8 mmol/gm of protein). While CAT level in HB smokers’ group was significantly lower than the control group (22545.4±504 vs 24772.0±344.6 mU/ml). Also, a clear difference for GPx level was found between study groups (1091.6±122 vs. 3144.9± 409mU/ml). However, no significant differences were observed between the two groups regarding the SOD and MDA levels as well as the lipids concentration.
Conclusions: HB smoking is associated with increased levels of carbonyl proteins and decreased levels of catalase, and glutathione peroxidase in the plasma, which might contribute to the several adverse health effects associated with HB smoking.