bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of topical agents on skin surface dose in volumetric modulated arc therapy for head and neck cancer
Authors: Ueda Hikari , Ueda Yoshihiro , Ikawa Toshiki , Ohira Shingo , Miyazaki Masayoshi , Enomoto Kazumi , Sakai Kayo , Konishi Koji 
Published: June 2023

Abstract
In volumetric modulated arc therapy (VMAT), the effect of an increase in skin surface dose due to topical agents might be negligible. We investigated the bolus effects of three types of topical agents in VMAT for head and neck cancer (HNC). Topical agents of different thicknesses (0.1, 0.5 and 2 mm) were prepared. When each topical agent was set, the surface doses were measured for the anterior static field and VMAT, with and without a thermoplastic mask. No significant differences were observed among the three topical agents. For topical agent thicknesses of 0.1, 0.5 and 2 mm, the increases in surface dose for the anterior static field without the thermoplastic mask were 7–9, 30–31 and 81–84%, respectively. With the thermoplastic mask, the corresponding increases were 5, 12–15 and 41–43%, respectively. The increases in surface dose for VMAT without the thermoplastic mask were 5–8, 16–19 and 36–39%, respectively, and those with the thermoplastic mask were 4, 7–10 and 15–19%, respectively. The rate of increase in surface dose with the thermoplastic mask was smaller than that without the thermoplastic mask. The increase in surface dose with topical agents of clinical standard thickness (0.02 mm) was estimated to be 2% with the thermoplastic mask. The increase in surface dose with topical agents in dosimetric simulation, compared with control situation, is not significant in clinical conditions for HNC patients.
Surgical management of a rare giant ovarian serous cystadenoma with distinctive clinical manifestations
Authors: Shokrollahi Nima , Nouri Mohammad , Movahedi Alireza , Kamani Fereshteh 
Published: June 2023

Abstract
Giant ovarian cysts are categorized with sizes &gt;10 cm. After reaching huge diameters, these rare tumors cause clinical symptoms such as nausea, vomiting or abdominal pain. We present a 29-year-old woman with a giant unique cystadenoma represented with unusual clinical features like low back pain and progressive constipation. Specific imaging methods demonstrated an adnexal lesion in the form of an enormous ovarian cyst; afterward, an open laparotomy was recommended to access the abdominal cavity. The critical role of timely diagnosis and accurate workups for giant ovarian cysts in increasing patients’ life expectancy and quality of life is discussed.
Abrupt onset of suture granuloma 27 years after hemithyroidectomy
Authors: Alghanemi Ryan , Steinmüller Thomas 
Published: June 2023

Abstract
Suture granuloma is a rare complication after thyroidectomy and usually manifests as a chronic inflammation mimicking cancer or even tuberculous lymphadenitis and can be expected within the first 2 postoperative years. We report the case of a 53-year-old woman who presented, 27 years after her first hemithyroidectomy, with a sudden onset of a growing lump on the same site. Neck magnetic resonance imaging revealed a fast-growing tumor suggestive of a cancerous lesion. An excisional biopsy revealed only acute inflammation with pus formation. During surgery, we excised 20 thickly ligated sutures from the neck. These sutures were suggested to have caused the suture granulomas.
Comparative Venom Multiomics Reveal the Molecular Mechanisms Driving Adaptation to Diverse Predator–Prey Ecosystems in Closely Related Sea Snakes
Authors: Zheng Hao , Wang Junjie , Fan Hairong , Wang Shuocun , Ye Ruiwei , Li Linxue , Wang Sheng , Li An , Lu Yiming 
Published: June 2023

Abstract
Predator–prey arms races are ideal models for studying the natural selection and adaptive evolution that drive the formation of biological diversity. For venomous snakes, venom is a key bridge linking snakes with their prey, but whether and how venom evolves under the selection of diet remains unclear. Here, we focused on two closely related sea snakes, Hydrophis cyanocinctus and Hydrophis curtus, which show significant differences in prey preferences. Data-independent acquisition (DIA)–based proteomic analysis revealed different degrees of homogeneity in the venom composition of the two snakes, which was consistent with the differential phylogenetic diversity of their prey. By investigating the sequences and structures of three-finger toxins (3FTx), a predominant toxin family in elapid venom, we identified significant differences between the two sea snakes in the binding activity of 3FTx to receptors from different prey populations, which could explain the trophic specialization of H. cyanocinctus. Furthermore, we performed integrated multiomic profiling of the transcriptomes, microRNAs (miRNAs), long noncoding RNAs (lncRNAs), and proteomes of the venom glands; constructed venom-related mRNA–miRNA–lncRNA networks; and identified a series of noncoding RNAs involved in the regulation of toxin gene expression in the two species. These findings are highly informative for elucidating the molecular basis and regulatory mechanisms that account for discrepant venom evolution in response to divergent diets in closely related snakes, providing valuable evidence for the study of coselection and coevolution in predator–prey ecosystems.
The management of incidental meningioma: An unresolved clinical conundrum
Authors: Islim Abdurrahman I , Millward Christopher P , Mills Samantha J , Fountain Daniel M , Zakaria Rasheed , Pathmanaban Omar N , Mathew Ryan K , Santarius Thomas , Jenkinson Michael D 
Published: June 2023

Abstract
The widespread availability and use of brain magnetic resonance imaging and computed tomography has led to an increase in the frequency of incidental meningioma diagnoses. Most incidental meningioma are small, demonstrate indolent behavior during follow-up, and do not require intervention. Occasionally, meningioma growth causes neurological deficits or seizures prompting surgical or radiation treatment. They may cause anxiety to the patient and present a management dilemma for the clinician. The questions for both patient and clinician are “will the meningioma grow and cause symptoms such that it will require treatment within my lifetime?” and “will deferment of treatment result in greater treatment-related risks and lower chance of cure?.” International consensus guidelines recommend regular imaging and clinical follow-up, but the duration is not specified. Upfront treatment with surgery or stereotactic radiosurgery/radiotherapy may be recommended but this is potentially an overtreatment, and its benefits must be balanced against the risk of related adverse events. Ideally, treatment should be stratified based on patient and tumor characteristics, but this is presently hindered by low-quality supporting evidence. This review discusses risk factors for meningioma growth, proposed management strategies, and ongoing research in the field.
Advances in PET imaging for meningioma patients
Authors: Galldiks Norbert , Albert Nathalie L , Wollring Michael , Werner Jan-Michael , Lohmann Philipp , Villanueva-Meyer Javier E , Fink Gereon R , Langen Karl-Josef , Tonn Joerg-Christian 
Published: June 2023

AbstractIn patients with meningioma, diagnosis and treatment planning are predominantly based on anatomical imaging using MRI or CT. Constraints of these imaging modalities include precise meningioma delineation—especially at the skull base, in the case of trans-osseus growth, and in tumors with complex geometry—and the differentiation of post-therapeutic reactive changes from meningioma relapse. Advanced metabolic imaging using PET may help to characterize specific metabolic and cellular features providing additional information beyond the information derived from anatomical imaging alone. Accordingly, the use of PET in meningioma patients is steadily increasing. This review summarizes recent advances in PET imaging helpful for improving the clinical management of patients with meningioma.
Paediatrics and discomfort with death and dying
Authors: Johnson K Taneille , Dahl Nicole 
Published: June 2023

Abstract
Death and dying, while uncommon in day-to-day paediatrics practice, are becoming increasingly common occurrences as children with life-limiting illnesses are living longer. We reflect on our experiences with death and dying in our residency training and whether paediatrics, as a specialty, is uncomfortable with death. Paediatric trainees should be included in honest discussions about disease trajectories and participate in providing end-of-life care. Anticipatory guidance helps personalize care and can prevent unnecessary procedures or suffering that patients may experience. While trainees may not be present at the end-of-life for many patients, managing death and dying are important competencies for future paediatricians. Current paediatricians should reflect on their comfort with death and how this may impact their patient care.
The pyrenoid: the eukaryotic CO2-concentrating organelle
Authors: He Shan , Crans Victoria L , Jonikas Martin C 
Published: June 2023

AbstractThe pyrenoid is a phase-separated organelle that enhances photosynthetic carbon assimilation in most eukaryotic algae and the land plant hornwort lineage. Pyrenoids mediate approximately one-third of global CO2 fixation, and engineering a pyrenoid into C3 crops is predicted to boost CO2 uptake and increase yields. Pyrenoids enhance the activity of the CO2-fixing enzyme Rubisco by supplying it with concentrated CO2. All pyrenoids have a dense matrix of Rubisco associated with photosynthetic thylakoid membranes that are thought to supply concentrated CO2. Many pyrenoids are also surrounded by polysaccharide structures that may slow CO2 leakage. Phylogenetic analysis and pyrenoid morphological diversity support a convergent evolutionary origin for pyrenoids. Most of the molecular understanding of pyrenoids comes from the model green alga Chlamydomonas (Chlamydomonas reinhardtii). The Chlamydomonas pyrenoid exhibits multiple liquid-like behaviors, including internal mixing, division by fission, and dissolution and condensation in response to environmental cues and during the cell cycle. Pyrenoid assembly and function are induced by CO2 availability and light, and although transcriptional regulators have been identified, posttranslational regulation remains to be characterized. Here, we summarize the current knowledge of pyrenoid function, structure, components, and dynamic regulation in Chlamydomonas and extrapolate to pyrenoids in other species.
Gibberellin signaling modulates flowering via the DELLA–BRAHMA–NF-YC module in Arabidopsis
Authors: Zhang Chunyu , Jian Mingyang , Li Weijun , Yao Xiani , Tan Cuirong , Qian Qian , Hu Yilong , Liu Xu , Hou Xingliang 
Published: June 2023

Abstract
Gibberellin (GA) plays a key role in floral induction by activating the expression of floral integrator genes in plants, but the epigenetic regulatory mechanisms underlying this process remain unclear. Here, we show that BRAHMA (BRM), a core subunit of the chromatin-remodeling SWItch/sucrose nonfermentable (SWI/SNF) complex that functions in various biological processes by regulating gene expression, is involved in GA-signaling-mediated flowering via the formation of the DELLA–BRM–NF-YC module in Arabidopsis (Arabidopsis thaliana). DELLA, BRM, and NF-YC transcription factors interact with one another, and DELLA proteins promote the physical interaction between BRM and NF-YC proteins. This impairs the binding of NF-YCs to SOC1, a major floral integrator gene, to inhibit flowering. On the other hand, DELLA proteins also facilitate the binding of BRM to SUPPRESSOR OF OVEREXPRESSION OF CONSTANS1 (SOC1). The GA-induced degradation of DELLA proteins disturbs the DELLA–BRM–NF-YC module, prevents BRM from inhibiting NF-YCs, and decreases the DNA-binding ability of BRM, which promote the deposition of H3K4me3 on SOC1 chromatin, leading to early flowering. Collectively, our findings show that BRM is a key epigenetic partner of DELLA proteins during the floral transition. Moreover, they provide molecular insights into how GA signaling coordinates an epigenetic factor with a transcription factor to regulate the expression of a flowering gene and flowering in plants.
Alternative response officers: investing in policing alternatives and community safety in Saskatoon, Canada
Authors: Hodgkinson Tarah , Pringle Darren 
Published: June 2023

Abstract
The current demand for policing alternatives has never been higher. In Canada, police services are increasingly exploring these alternatives to address this demand. In 2021, the Saskatoon Police Service (SPS), in collaboration with the city of Saskatoon, university partners, and numerous community stakeholders, introduced an alternative response officer (ARO). The ARO is a special constable, meaning that they are sworn in as a peace officer, but are tasked with addressing community safety concerns that do not require an armed officer to attend. SPS introduced the ARO in the downtown area of Saskatoon with the intent to increase interoperability with other community service providers, increase uniformed presence in the area to act as reassurance and deterrence, and to decrease the need for armed officers to attend low-level social disorder or social welfare calls. Using activity counts and calls for service data, this study examines the implementation and early outcomes of policing alternatives for community support and policing resource management. This study has implications for investing and expanding policing alternatives and reducing policing costs to municipalities.
Deeply embedded core normative values and their relationship with perceptions of legitimacy
Authors: Factor Roni , Mehozay Yoav 
Published: June 2023

Abstract
This article presents a tailored research tool developed to explore and test the recent theory of deeply embedded core normative values, which asserts that beliefs about the legitimacy of law-enforcement authorities derive in part from profound cultural orientations through which individuals act in and interpret the world. The model is based on a typology of four core normative value systems, namely religious–traditional, liberal, republican–communitarian, and ethno-national, which are associated in different ways with legitimacy. We first conducted in-depth interviews with 45 participants to develop the research tool (questionnaire), then performed a large-scale representative survey among 1,617 Israeli respondents. The findings support the main premises of the model. They show that liberal, republican–communitarian, and religious–traditional values have significant associations with two measures of legitimacy (trust and obligation to obey the police), and that these associations generally hold beyond perceptions of police conduct and performance.
Dividing Authority Three Ways: Federal–Tribal–State Relations afterOklahoma v. Castro-Huerta
Authors: Carlson Kirsten Matoy 
Published: June 2023

AbstractThe U.S. Supreme Court’s decision in Oklahoma v. Castro-Huerta has the potential to rework the long-standing division of authority among federal, state, and tribal governments. In issuing its decision in this June 2022 case, the majority departed from its previous decisions and congressional policy by enabling state governments to exercise criminal authority over non-Indians in Indian Country. This article examines the implications of Castro-Huerta for federal, tribal, and state governments on the ground in Indian Country as well as for scholarship and teaching on federal–tribal–state relations.
The Timing of Implementation of COVID-19 Lockdown Policies: Does Decentralization Matter?
Authors: Tselios Vassilis 
Published: June 2023

Abstract
All countries implemented policies to mitigate the spread of the SARS-CoV-2 virus and control fatalities from COVID-19. Although early actions were pivotal in reducing confirmed cases and deaths, the timing of the introduction of these policies differed from country to country. This article assesses and compares the behavior of various decentralized countries in responding to the COVID-19 pandemic, focusing on the timing of implementation of containment measures and viewing timeliness of adoption as denoting a country’s level of responsiveness to a health crisis. Using international databases, this article finds that more decentralized countries delayed the start of containment measures. This article also finds that larger and more densely populated countries were more likely to delay implementation of these policies.
Ω-bounds for the partial sums of some modified Dirichlet characters
Authors: Aymone Marco 
Published: June 2023

Abstract
We consider the problem of Ω bounds for the partial sums of a modified character, i.e., a completely multiplicative function f such that $f(p)=\chi(p)$ for all but a finite number of primes p, where χ is a primitive Dirichlet character. We prove that in some special circumstances, $\sum_{n\leq x}f(n)=\Omega((\log x)^{|S|})$, where S is the set of primes p, where $f(p)\neq \chi(p)$. This gives credence to a corrected version of a conjecture of Klurman et al., Trans. Amer. Math. Soc., 374 (11), 2021, 7967–7990. We also compute the Riesz mean of order k for large k of a modified character and show that the Diophantine properties of the irrational numbers of the form $\log p / \log q$, for primes p and q, give information on these averages.
Factor Timing with Portfolio Characteristics
Authors: Kagkadis Anastasios , Nolte Ingmar , Nolte Sandra , Vasilas Nikolaos 
Published: June 2023

Abstract
In a factor timing context, academic research has focused on identifying a set of predictors that can explain the dynamics of factor portfolios. We propose an alternative approach for timing factor portfolio returns by exploiting the information from their portfolio characteristics. Different combinations of dimension reduction techniques are employed to independently reduce the number of both predictors and portfolios to predict. Characteristic-based models outperform existing methods in terms of exact predictability, as well as investment performance. (JEL G10, G11, C52, C55)
The efficacy of tobacco cessation treatment for African American adults: a systematic review
Authors: Dawson Darius B , Budhwani Shahereez , Breland Jessica Y , Kunik Mark E , Fletcher Terri L 
Published: June 2023

Abstract
Despite proliferation of evidence-based tobacco cessation treatments, African American adults still suffer higher rates of tobacco-related diseases than White adults. Although tobacco cessation treatment is efficacious, there is a need to reassess the efficacy of tobacco cessation treatment for African American adults. Previous reviews of tobacco cessation treatment studies conducted through 2007 among African American adults highlight the limited research in this area and inconsistent findings on treatment characteristics impacting efficacy. This systematic review examined the efficacy of combined behavioral and pharmacological tobacco cessation treatment for African American adults. Database searches were used to identify studies examining tobacco cessation treatment for predominantly African American samples (&gt;50%). Eligible studies were completed between 2007 and 2021 and (i) involved randomization comparing active combined treatment to a control comparison group and (ii) reported abstinence outcomes at 6 and/or 12 months. Ten studies met inclusion criteria. Active treatment groups typically consisted of a combination of nicotine replacement therapy and behavioral counseling. Abstinence rates for African American adults ranged from 10.0% to 34% in active treatment groups compared to 0.0%–40% in comparison control groups. Our results support the efficacy of combined treatment for tobacco cessation among African American adults. However, cessation rates for African American adults found in this review are lower than those in the general adult population (15%–88%). Additionally, our findings highlight the limited number of studies examining African American tobacco cessation rates and testing of tailored treatment for this population.
Combined Platelet and Red Blood Cell Recovery during On-pump Cardiac Surgery Using same™ by i-SEP Autotransfusion Device: A First-in-human Noncomparative Study (i-TRANSEP Study)
Authors: Mansour Alexandre , Beurton Antoine , Godier Anne , Rozec Bertrand , Zlotnik Diane , Nedelec Fabienne , Gaussem Pascale , Fiore Mathieu , Boissier Elodie , Nesseler Nicolas , Ouattara Alexandre 
Published: June 2023

Background
Centrifugation-based autotransfusion devices only salvage red blood cells while platelets are removed. The same™ device (Smart Autotransfusion for ME; i-SEP, France) is an innovative filtration-based autotransfusion device able to salvage both red blood cells and platelets. The authors tested the hypothesis that this new device could allow a red blood cell recovery exceeding 80% with a posttreatment hematocrit exceeding 40%, and would remove more than 90% of heparin and 75% of free hemoglobin.

Methods
Adults undergoing on-pump elective cardiac surgery were included in a noncomparative multicenter trial. The device was used intraoperatively to treat shed and residual cardiopulmonary bypass blood. The primary outcome was a composite of cell recovery performance, assessed in the device by red blood cell recovery and posttreatment hematocrit, and of biologic safety assessed in the device by the washout of heparin and free hemoglobin expressed as removal ratios. Secondary outcomes included platelet recovery and function and adverse events (clinical and device-related adverse events) up to 30 days after surgery.

Results
The study included 50 patients, of whom 18 (35%) underwent isolated coronary artery bypass graft, 26 (52%) valve surgery, and 6 (12%) aortic root surgery. The median red blood cell recovery per cycle was 86.1% (25th percentile to 75th percentile interquartile range, 80.8 to 91.6) with posttreatment hematocrit of 41.8% (39.7 to 44.2). Removal ratios for heparin and free hemoglobin were 98.9% (98.2 to 99.7) and 94.6% (92.7 to 96.6), respectively. No adverse device effect was reported. Median platelet recovery was 52.4% (44.2 to 60.1), with a posttreatment concentration of 116 (93 to 146) · 109/l. Platelet activation state and function, evaluated by flow cytometry, were found to be unaltered by the device.

Conclusions
In this first-in-human study, the same™ device was able to simultaneously recover and wash both platelets and red blood cells. Compared with preclinical evaluations, the device achieved a higher platelet recovery of 52% with minimal platelet activation while maintaining platelet ability to be activated in vitro.

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