bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of decision to delivery interval and its effect on feto‐maternal outcomes in Category‐I emergency cesarean section deliveries in Phuentsholing General Hospital, 2020: A retrospective cross‐sectional study
Authors: Dorjey Yeshey , Tshomo Yezer , Wangchuk Dorji , Bhandari Purushottami , Dorji Choki , Pradhan Diptika , Pemo Rinzin 
Published: January 2023

AbstractBackground and AimsWhen there is an immediate threat to maternal or fetal life, it is recommended to deliver within 30 min of the decision to have favorable perinatal outcomes. However, there is no data on the delivery intervals for Category‐I emergency cesarean section in Bhutan. The study evaluated the decision to delivery interval (DDI) and its effect on perinatal and maternal outcomes in Category‐I emergency cesarean section.MethodsA retrospective cross‐sectional study was conducted at the Phuentsholing General Hospital, Bhutan, from January 1, 2020 to December 31, 2020. Mothers who underwent Category‐I emergency cesarean section were included. The demographic variables, patient transfer time, anesthesia time, operation time, DDI, and maternal and perinatal outcomes were recorded in a standard proforma. The data were analyzed using SPSS version 23.ResultsOf 78 Category‐I emergency cesarean sections, only 23 (29.5%) of the cases were able to perform within 30 min of the DDI. The median (interquartile range) DDI was 37 (30–44) min. More time was taken by anesthetists to administer anesthesia (20 [15–8] min). Fetal distress (40, 51.3%) was the commonest indication. The longest DDI was around 39 min for prolonged labor, and the shortest was 26 min for failed instrumental delivery. Over half of the newborns delivered more than 30 min of DDI had low APGAR scores (25, 32.1%) at 1 min and meconium was present (23, 29.5%). Intensive care was required in 11 (14.1%), of which there was 1 (1.3%) neonatal death.ConclusionThe Category‐I emergency cesarean sections performed within recommended DDI of 30 min were much less. The main delay was due to the longer time taken for the patient transfer and time taken by the anesthetists to administer anesthesia. Perinatal outcomes were favorable when the deliveries were conducted within 30 min of DDI.
Immune‐Hot tumor features associated with recurrence in early‐stage ovarian clear cell carcinoma
Authors: Huang Ruby Yun‐Ju , Huang Kuan‐Ju , Chen Ko‐Chen , Hsiao Sheng‐Mou , Tan Tuan Zea , Wu Chin‐Jui , Hsu Ching , Chang Wen‐Chun , Pan Chen‐Yu , Sheu Bor‐Ching , Wei Lin‐Hung 
Published: January 2023

AbstractOvarian clear cell carcinoma (OCCC) is a distinct histotype of ovarian cancer, which usually presages a worse prognosis upon recurrence. Identifying patients at risk for relapse is an unmet need to improve outcomes. A retrospective cohort analysis of 195 early‐stage OCCC patients diagnosed between January 2011 and December 2019 at National Taiwan University Hospital was conducted to identify prognostic factors for recurrence, progression‐free survival (PFS) and overall survival (OS). Molecular profiling of tumors was performed in a case‐controlled cohort matched for adjuvant therapy for biomarker discovery. Multivariate Cox proportional hazard model revealed that paclitaxel‐based chemotherapy was associated with better PFS than nonpaclitaxel chemotherapy (HR = 0.19, P = .006). The addition of bevacizumab was associated with better PFS, compared to no bevacizumab (HR = 0.09, P = .02). Neither showed significant improvement in OS. Recurrence is associated with an Immune‐Hot tumor feature (P = .03), the CTLA‐4‐high subtype (P = .01) and increased infiltration of immune cells in general. The Immune‐Hot feature (HR = 3.39, P = .005) and the CTLA‐4‐high subtype (HR = 2.13, P = .059) were associated with worse PFS. Immune‐Hot tumor features could prognosticate recurrence in early‐stage OCCC.
Neonatal exposure to low‐dose X‐ray causes behavioral defects and abnormal hippocampal development in mice
Authors: Liu Yuanduo , Ma Hongying , Wang Yangyang , Ren Boxu , Liu Lian , Sun Anbang , Tang Fengru 
Published: January 2023

AbstractDevelopment of the hippocampus is critical for its normal maturation. However, there is no systematic study on the effects of low‐dose (≤2 Gy) neonatal X‐ray exposure on different cells at different developmental stages of the mouse hippocampus. The present study demonstrated that irradiation with 2 Gy at postnatal day (PD) 3 in mice induced anxiety and impairment of spatial learning and memory in adult mice. Neuroinflammatory cells were observed in the dentate gyrus (DG) and CA3 areas of the hippocampus at PD3 + 1. X‐ray irradiation impaired neuronal complexity and neurogenesis. However, the number of astrocytes and microglia in the hippocampus was increased the first day after irradiation, and then decreased 21 days later. The protein expression levels of NF‐κB, C/EBP homologous protein (CHOP), and γH2A histone family member X (γH2AX) increased from 7 to 21 days after irradiation, or till 90 days after irradiation for IL‐1β, whereas those of hippocampal sirtuin1 (SIRT1) decreased after 21 days of irradiation at PD3. These results suggest that neonatal X‐ray irradiation‐induced neuroinflammation impaired neuroplasticity and neurogenesis in the hippocampus, leading to the anxiety and spatial memory disorder during adulthood. The mechanisms involved in the induction of developmental neurotoxicity following low‐dose irradiation may involve the inflammation‐mediated signaling pathway IL‐1β/ SIRT1/CHOP.
Proximity bias: Interactive effect of spatial distance and outcome valence on probability judgments
Authors: Hong Jennifer Seokhwa , Longoni Chiara , Morwitz Vicki G. 
Published: January 2023

AbstractAcross a range of decision contexts, we provide evidence of a novel proximity bias in probability judgments, whereby spatial distance and outcome valence systematically interact in determining probability judgments. Six hypothetical and incentive‐compatible experiments (combined N = 4007) show that a positive outcome is estimated as more likely to occur when near than distant, whereas a negative outcome is estimated as less likely to occur when near than distant (studies 1–6). The proximity bias is explained by wishful thinking and thus perceptions of outcome desirability (study 3), and it does not manifest when an outcome is less relevant for the self, such as the case of outcomes with little consequence for the self (studies 4 and 5) or when estimating outcomes for others who are irrelevant to the self (study 6). Overall, the proximity bias we document deepens our understanding of the antecedents of probability judgments.
A decrease in the incidence of encephalitis in South Korea during the COVID‐19 pandemic: A nationwide study between 2010 and 2021
Authors: Kim Se Hee , Baek Jee Yeon , Han Minkyung , Lee Myeongjee , Lim Sung Min , Lee Ji Young , Kang Ji‐Man , Jung Inkyung , Kang Hoon‐Chul , Ahn Jong Gyun 
Published: January 2023

AbstractLimited data are available on the impact of the coronavirus disease (COVID‐19) pandemic on encephalitis. Therefore, we evaluated trends in encephalitis in South Korea between 2010 and 2021 using data from the National Health Insurance Service. During the pandemic (February 2020 to 2021), the monthly incidence of encephalitis declined by 0.027 per 100 000 population (95% confidence interval [CI]: −0.055 to 0.001, p = 0.062) compared to that before the pandemic. In subgroup analysis, the estimated coefficient for level change during the pandemic in the 0–4 and 5–9 years age groups were −2.050 (95% CI: −2.972 to −1.128, p < 0.001) and −0.813 (95% CI: −1.399 to −0.227, p = 0.008), respectively. The annual incidence of encephalitis during the pandemic period significantly decreased in the 0–4 and 5–9 years age groups (incidence rate ratio: 0.34 [p = 0.007] and 0.28 [p = 0.024], respectively). The intensive care unit admission rate (39.1% vs. 58.9%, p  < 0.001) and cases of death (8.9% vs. 11.1%, p < 0.001) decreased significantly during the pandemic compared to the prepandemic. During the pandemic, the incidence of encephalitis decreased markedly in South Korea, particularly in children aged ≤9 years. In addition, there were changes in the clinical outcome of encephalitis during the COVID‐19 pandemic.
Glacial fluctuations during the Last Glacial Maximum and Lateglacial in the Zhuxi and Songlong valleys, eastern Nyainqêntanglha Range, southeastern Tibet
Authors: Xie Jinming , Yang Taibao , Zhou Shangzhe , Xu Liubing , Ou Xianjiao , Hu Gang 
Published: January 2023

ABSTRACTThis study outlines the paleoglacial history and paleoclimatic conditions that were present during the Last Glacial Maximum (LGM) and Lateglacial (LG) in the Songlong and Zhuxi valleys in the eastern Nyainqêntanglha Range, southeastern Tibet. Two sets of moraines were identified at the valley mouths, and were dated using cosmogenic 10Be exposure and optically stimulated luminescence (OSL) dating. The ages suggest that two glaciations occurred at ~20–21 and ~14–16 ka, respectively, coinciding with the LGM and LG. Using glacier–climate modeling, temperature drops were calculated to have ranged from 6.3 to 7.8 °C during the LGM–LG, with precipitation being 40–60% of the present‐day value. The results in the modeled domain appear generally consistent with other climatic records from the Tibetan Plateau. Glacial advances in monsoon‐dominated southeastern Tibet during the LGM–LG were probably driven by low temperatures rather than by high precipitation, which was usually produced by an enhanced Indian Summer Monsoon during periods of climatic warming.
Composition, morphology, interfacial rheology and emulsifying ability of soy hull polysaccharides extracted with ammonium oxalate and sodium citrate as extractants
Authors: Yang Hui , Liu Yexuan , Wang Shengnan , Zhao Lingling , Liu He , Liu Jun , Zhu Danshi 
Published: January 2023

AbstractBACKGROUNDSoy hull, a by‐product of crop processing, is rich in pectin‐like polysaccharides that have potential for thickening, gelling and emulsifying applications. The effect of ammonium oxalate (SHPA) and sodium citrate (SHPS) on the conformation, physicochemical properties and emulsifying ability of soy hull polysaccharide (SHP) were investigated.RESULTSThe composition analysis showed that SHPS had more polysaccharide, protein, and higher molecular weight than SHPA. Images of atomic force microscopy (AFM) and scanning electron microscopy (SEM) showed that SHPS molecules appeared spherical bodies with smooth and firm surfaces, while SHPA molecules appeared chain‐like bodies with rough and wrinkled surface. At the oil–water interface, SHPS adsorbed faster and formed a more elastic interfacial layer than SHPA. The characterization of the prepared emulsions showed that the SHPS emulsion was a smaller particle size and more stable system within 30 days than SHPA emulsion, especially at the SHPS concentration of 9 mg mL−1. Images of cryo‐scanning electron microscopy (cryo‐SEM) also demonstrated SHPS formed clearer network structure on the surface of the oil droplets, compared to SHPA.CONCLUSIONOverall, ammonium oxalate and sodium citrate significantly influenced the composition and properties of the SHP. SHPS exhibited a better emulsifying ability than SHPA, which was mainly due to the higher protein content of SHPS and the sodium ion (Na+) residue of sodium citrate. This study is useful for the extraction and application of SHP and other plant‐based polysaccharides. © 2023 Society of Chemical Industry.
Post‐thyroidectomy voice and swallowing disorders and association with laryngopharyngeal reflux: A scoping review
Authors: Rodriguez Alexandra , Hans Stéphane , Lechien Jérôme R. 
Published: January 2023

AbstractObjectivePostthyroidectomy voice and swallowing symptoms (PVSS) may occur even in absence of laryngeal nerve injuries, which remains poorly understood. The objective of this review was to investigate the occurrence of PVSS and the potential etiological role of laryngopharyngeal reflux (LPR).DesignScoping review.MethodsThree investigators search PubMed, Cochrane Library, and Scopus databases for studies investigating the relationship between reflux and PVSS. The authors adhered to PRISMA statements and the following outcomes were investigated: age, gender, thyroid features, reflux diagnosis, association outcomes, and treatment outcomes. Based on the study findings and bias analysis, authors proposed recommendations for future studies.ResultsEleven studies met our inclusion criteria, accounting for 3829 patients (2964 females). Postthyroidectomy swallowing and voice disorders were found in 5.5%–64%; and 16%–42% of patients, respectively. Prospectively, some results suggested an improvement of swallowing/voice disorders postthyroidectomy, whereas others did not observe significant changes. The prevalence of reflux ranged from 16.6% to 25% of subjects who benefited from thyroidectomy. There was an important heterogeneity between studies regarding the profile of included patients, the PVSS outcomes used, the delay of PVSS assessment and reflux diagnosis, making difficult the study comparison. Some recommendations were provided to guide future studies, especially about the reflux diagnosis approach and clinical outcomes.ConclusionThe potential etiological role of LPR in PVSS is not demonstrated. Future studies are needed to demonstrate an increase of pharyngeal reflux events with objective findings from prethyroidectomy to postthyroidectomy.Level of Evidence3a.
Highly Pressure‐Sensitive, Temperature Independent Luminescence Ratiometric Manometer Based on MgO:Cr3+ Nanoparticles
Authors: Szymczak Maja , Runowski Marcin , Lavín Victor , Marciniak Lukasz 
Published: January 2023

AbstractReliable remote pressure readout is possible only if high sensitivity of the measurement and independence from other physical factors are ensured. Among the parameters most strongly affecting measurements, temperature plays the most important role. In luminescence manometry, ratiometric measurement facilitates rapid pressure measurement ensuring high sensitivity of measurement while maintaining accuracy. Therefore, this paper compares the manometric performance of two ratiometric approaches in the material based on the luminescence of Cr3+ ions: using the intensity ratio of 2E→4A2 to 4T2→4A2 and a new approach based on the luminescence intensity ratio of 4T2→4A2 band recorded in two spectral ranges. Using the first approach, a manometer with an unprecedented sensitivity of SR = 40% GPa−1 is developed. However, the second approach provides completely temperature‐invariant pressure measurement with a sensitivity of SR = 9.8% GPa−1. The presented results indicate that the MgO:Cr3+ nanoparticles are a highly reliable and sensitive candidate for a new luminescent manometer.
Dosimetric characterization of a novel commercial plastic scintillation detector with an MR‐Linac
Authors: Ferrer Carlos , Huertas Concepción , García David , Sáez Moisés 
Published: January 2023

AbstractBackgroundPlastic scintillators have been used as radiation detectors for the past few years, as they are water‐equivalent and independent of the dose, dose rate, and angle of incidence. In addition, they are also independent of the presence of a magnetic field and could be used for in vivo dosimetry in an MR‐Linac. With the advent of a new commercial scintillation detector, Blue Physics Model 10, its characterization has been performed on an MR‐Linac with a view to future applications.PurposeTo perform the dosimetric characterization and study potential applications of a novel commercial plastic scintillation detector in a MR‐Linac.MethodsScintillation detector description, calibration procedure, short‐term repeatability, dose‐response linearity, dose‐rate dependence, angular dependence, and temperature dependence have been studied. Percent‐depth‐dose (PDD) and beam profiles were measured for small fields and a standard field, as well as output factors, for comparison with other PTW detectors: a diamond diode and PinPoint and Semiflex 3D ionization chambers. The suitability of the plastic scintillator for in vivo dosimetry in a magnetic field has also been studied measuring the dose to a point in an anthropomorphic phantom while acquiring MR imaging. This measured dose was compared with that calculated with Monaco planning system and with that measured with a PTW Semiflex 3D chamber, the latter without acquiring MR images.ResultsShort‐term repeatability presented negligible variations (<0.4%) for 100 and 20 MU. Similar results were obtained for dose‐response linearity and dose‐rate dependence. A small angular dependence was determined, while the scintillator resulted practically independent of the temperature. PDDs showed excellent agreement except in the build‐up region, and calculated penumbras with the profiles given by the scintillator were between the ones obtained with the diamond detector and the PinPoint ionization chamber. Measured OF with the scintillator were the highest between all detectors, 1.26% higher than the value obtained with the microdiamond for the smallest field measured, 0.5 × 0.5 cm2. Finally, the total dose to a point measured with the scintillator was 0.51% higher compared to that calculated by the planning system.ConclusionThe Blue Physics model 10 scintillation system showed excellent dosimetric characteristics. Its response independent of the temperature and the presence of a magnetic field make it suitable for in vivo dosimetry in an MR‐Linac while acquiring MR images, which could solve the impossibility of performing a dosimetric QA for each adapted plan. Furthermore, its temporal resolution allows independent radiation pulses to be measured and visualized, which could be used in future applications.
Phase‐regularized and displacement‐regularized compressed sensing for fast magnetic resonance elastography
Authors: Mohammed Shahed , Kozlowski Piotr , Salcudean Septimiu 
Published: January 2023

AbstractLiver magnetic resonance elastography (MRE) is a noninvasive stiffness measurement technique that captures the tissue displacement in the phase of the signal. To limit the scanning time to a single breath‐hold, liver MRE usually involves advanced readout techniques such as simultaneous multislice (SMS) or multishot methods. Furthermore, all these readout techniques require additional in‐plane acceleration using either parallel imaging capabilities, such as sensitivity encoding (SENSE), or
‐space undersampling, such as compressed sensing (CS). However, these methods apply a single regularization function on the complex image. This study aims to design and evaluate methods that use separate regularization on the magnitude and phase of MRE to exploit their distinct spatiotemporal characteristics. Specifically, we introduce two compressed sensing methods. The first method, termed phase‐regularized compressed sensing (PRCS), applies a two‐dimensional total variation (TV) prior to the magnitude and two‐dimensional wavelet regularization to the phase. The second method, termed displacement‐regularized compressed sensing (DRCS), exploits the spatiotemporal redundancy using 3D total variation on the magnitude. Additionally, DRCS includes a displacement fitting function to apply wavelet regularization to the displacement phasor. Both DRCS and PRCS were evaluated with different levels of compression factors in three datasets: an in silico abdomen dataset, an in vitro tissue‐mimicking phantom, and an in vivo liver dataset. The reconstructed images were compared with the full sampled reconstruction, zero‐filling reconstruction, wavelet‐regularized compressed sensing, and a low rank plus sparse reconstruction. The metrics used for quantitative evaluation were the structural similarity index (SSIM) of magnitude (M‐SSIM), displacement (D‐SSIM), and shear modulus (S‐SSIM), and mean shear modulus. Results from highly undersampled in silico and in vitro datasets demonstrate that the DRCS method provides higher reconstruction quality than the conventional compressed sensing method for a wide range of stiffness values. Notably, DRCS provides 24% and 22% increase in D‐SSIM compared with CS for the in silico and in vitro datasets, respectively. Comparison with liver stiffness measured from full sampled data and highly undersampled data (CR=4) demonstrates that the DRCS method provided the strongest correlation (
=0.95), second‐lowest mean bias (−0.18 kPa, lowest for CS with −0.16 kPa), and lowest coefficient of variation (CV=3.6%). Our results demonstrate the potential of using DRCS to improve the reconstruction quality of accelerated MRE.
Relationship between self‐efficacy and physical activity among colorectal cancer patients: A cross‐sectional study
Authors: Li Xiaoyu , Geng Liangrong , Yuan Qiao , Yue Shujin 
Published: January 2023

AbstractAimTo investigate the current status of self‐efficacy and physical activity among Chinese colorectal cancer (CRC) patients and explore the relationship between them.DesignA cross‐sectional study.MethodsThis study was conducted on 282 CRC patients in China. Structured questionnaires were used to collect data on demographic and clinical information, self‐efficacy (Exercise Self‐Efficacy Scale [ESES]) and physical activity (International Physical Activity Questionnaire‐Short Form [IPAQ‐SF]).ResultsThe median (interquartile range) total self‐efficacy score for patients with CRC was 52.78 (42.08–61.11), and the median (interquartile range) total physical activity score was 1776.00 (1142.25–2812.05). Only 28.37% of CRC patients met the guideline recommendations for physical activity. The total self‐efficacy score was significantly positively correlated with the total physical activity score (r = 0.123, p = 0.040).Patient or Public ContributionCRC patients contributed to the data of this study. Hospital administrators facilitated the implementation of the study.
Primary care provider confidence in addressing opioid use disorder: A concept analysis
Authors: Turi Eleanor R. , McMenamin Amy , Wolk Courtney Benjamin , Poghosyan Lusine 
Published: January 2023

AbstractPrimary care providers (PCPs) are well‐positioned to provide care for opioid use disorder (OUD), yet very few address OUD regularly. One contributing factor may be PCPs' lack of confidence in their ability to effectively treat OUD. Evidence demonstrates that clinician confidence in home care and hospital settings is associated with improved care delivery and patient outcomes. However, a conceptual definition of PCP confidence in addressing OUD has yet to be established. The aim of this concept analysis is to enhance conceptual understanding of PCP confidence in addressing OUD and inform future measurement strategies. Following Walker and Avant's method of concept analysis, PubMed, PsycINFO, and Google Scholar were searched in October 2021. Manuscripts were included if they referenced confidence in relation to PCPs who provide care to adult patients with OUD. Studies conducted outside the US and not published in English were excluded. The search resulted in 18 studies which were synthesized to conceptualize PCP confidence in addressing OUD. Defining attributes include self‐efficacy, experience, and readiness to address OUD. These attributes may be influenced by organizational culture, training, support, and resources. Consequences of PCP confidence addressing OUD may include improved patient outcomes, improved delivery of and access to OUD care, and PCP attitude changes. This concept analysis—which grounds the concept of PCP confidence in addressing OUD in the theoretical and empirical literature—lays the framework for future measurement of the concept. This represents a critical first step towards developing strategies to enhance PCP confidence in addressing OUD.