bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Mystery of Mental Integrity: Clarifying Its Relevance to Neurotechnologies
Authors: Zohny Hazem , Lyreskog David M. , Singh Ilina , Savulescu Julian 
Published: August 2023

AbstractThe concept of mental integrity is currently a significant topic in discussions concerning the regulation of neurotechnologies. Technologies such as deep brain stimulation and brain-computer interfaces are believed to pose a unique threat to mental integrity, and some authors have advocated for a legal right to protect it. Despite this, there remains uncertainty about what mental integrity entails and why it is important. Various interpretations of the concept have been proposed, but the literature on the subject is inconclusive. Here we consider a number of possible interpretations and argue that the most plausible one concerns neurotechnologies that bypass one’s reasoning capacities, and do so specifically in ways that reliably lead to alienation from one’s mental states. This narrows the scope of what constitutes a threat to mental integrity and offers a more precise role for the concept to play in the ethical evaluation of neurotechnologies.
Editorial to the topical collection “Building stones and geomaterials through history and environments: from quarry to heritage. Insights on the conditioning factors - The Rolf Snethlage-Volume”
Authors: Siegesmund Siegfried , Sousa Luís , López-Doncel Rubén 
Published: August 2023

AbstractUnder the umbrella of “building stones”, a wide range of research topics are possible. A vast interdisciplinary scientific community provides valuable information that should be considered at several levels. These are the extraction of the stone from the quarry to their application on buildings, and the implementation of conservation measures when necessary. The present special issue contains 44 articles on the research into natural building stones. The editorial intention is to present the main highlights of each paper, which are grouped into the following sections in order to better understand the overall content: Quarrying, Physical–Mechanical Properties, Heritage and Weathering, Restoration and Techniques, Miscellaneous. This volume is dedicated to the memory of Professor Rolf Snethlage. The international community of applied geosciences has lost an important researcher and teacher. Therefore, a brief description of importance of the research carried out by Rolf Snethlage is presented at the end of the Editorial.
From Kiwi Peels’ “End-of-Life” to Gold Nanoparticles: the Upcycling of a Waste
Authors: Gubitosa Jennifer , Rizzi Vito , Maggi Filippo , Laurenzana Anna , Caprioli Giovanni , Anceschi Cecilia , Mustafa Ahmed M , Fini Paola , Cosma Pinalysa 
Published: August 2023

AbstractFollowing a green approach, kiwi peels (a waste) were washed in hot water to obtain a water-based polyphenolic extract (KPWW) used to reduce Au3+ (coming from a HAuCl4 water-based solution) for forming gold nanoparticles (AuNPs). Indeed, KPWW, as shown after performing high-performance liquid chromatography-mass spectrometry (HPLC/MS-MS) analysis, is mainly composed by different polyphenols acting as reductant agents, accomplishing a red-ox reaction and decorating the AuNPs-KPWW surface. Spectroscopic and morphologic techniques were used in synergy for investigating the AuNPs-KPWW main features. Polyhedral-shaped plasmonic nanoparticles with a mean size of 30±10 nm and a negative charge of −40 mV were thus obtained. The AuNPs’ stability was assessed under different working conditions, investigating the role of ionic strength, pH, and temperature. The photostability was also assessed by irradiating AuNPs-KPWW with a solar simulator lamp. Both temperature and solar light did not perturb AuNPs-KPWW. Thanks to the presence of polyphenols, the antioxidant and skin-lightening properties were positively demonstrated. Moreover, the protective role of AuNPs in scavenging H2O2 and ·OH was also investigated by inhibiting the oxidation of a biomolecule. The sunscreen ability of AuNPs-KPWW was also estimated, and the theoretical calculation of the sun protection factor (SPF) was determined. Finally, the AuNPs-KPWW biocompatibility was tested on endothelial colony-forming cells and normal dermal fibroblasts as human cell lines, revealing that AuNPs-KPWW did not affect cell viability and did not alter cell morphology, demonstrating their safety and their potential application in nanomedicine.
A target map of clinical combination therapies in oncology: an analysis of clinicaltrials.gov
Authors: Yang Jing , Kang Heming , Lyu Liyang , Xiong Wei , Hu Yuanjia 
Published: August 2023

AbstractCombination therapies have taken center stage for cancer treatment, however, there is a lack of a comprehensive portrait to quantitatively map the current clinical combination progress. This study aims to capture clinical combination therapies of the validated FDA-approved new oncology drugs by a macro data analysis and to summarize combination mechanisms and strategies in the context of the existing literature. A total of 72 new molecular entities or new therapeutic biological products for cancer treatment approved by the FDA from 2017 to 2021 were identified, and the data on their related 3334 trials were retrieved from the database of ClinicalTrials.gov. Moreover, these sampled clinical trials were refined by activity status and combination relevance and labeled with the relevant clinical arms and drug combinations, as well as drug targets and target pairs. Combination therapies are increasingly prevalent in clinical trials of new oncology drugs. From retrospective work, existing clinical combination therapies in oncology are driven by different patterns (i.e., rational design and industry trends). The former can be represented by mechanism-based or structure-based combinations, such as targeting different domains of HER2 protein or in-series co-targeting in RAF plus MEK inhibitors. The latter is an empirically driven strategy, including redundant combinations in hot targets, such as PD-1/PD-L1, PI3K, CDK4/6, and PARP. Because of an explosion in the number of clinical trials and the resultant shortage of available patients, it is essential to rationally design drug combinations.
THMs removal from aqueous solution using hydrochar enhanced by chitosan nanoparticles: preparation, characterization, kinetics, equilibrium studies
Authors: Jahin H. S. , Hesham A. , Awad Y. M. , El-Korashy S. , Khairy G. 
Published: August 2023

AbstractIn this study, novel green and economical techniques were established to synthesize modified banana peel hydrochar (HBP) through hydrothermal carbonization. Chitosan nanoparticles, a green adsorbent with multiple features, were prepared, characterized, and used to enhance the performance of the hydrochar in THMs removals. The optimal method for hydrothermal carbonization was determined based on previously cited methods. The dried banana peels and HBP were characterized using Fourier transform infrared spectrometer (FTIR), pH, zero point of charge, and bulk density. The prepared chitosan nanoparticles were characterized using scanning electron microscope (SEM), transmission electron microscope (TEM), and zeta potential techniques. The average size of chitosan nanoparticles was 12.1 nm, and a 1:1 mixture of HBP and chitosan nanoparticles was used for the removal of THMs from an aqueous solution. The concentrations of THMs were measured using gas chromatography, and the effect of THMs’ initial concentrations, adsorbent doses, temperature, and pH value on the adsorption capacity was studied. The results showed that the 1:1 mixture of HBP and chitosan nanoparticles was an efficient adsorbent for removing THMs from aqueous solutions. This adsorbent was found to be effective in removing THMs from the aqueous solution, even at low temperature and pH values, with an estimated maximum sorption capacity (qm) of 588.23 g g−1, exceeding numerous other adsorbents previously studied, and the regression coefficient (R2 = 0.9959) for data fitting with the Freundlich isotherm. This research has the potential to offer a great avenue for future development and implementation in water treatment. It could lead to improved methods of treating water, which would be beneficial for both environmental protection and economic growth. The developed adsorbent had high adsorption affinity toward the THMs compounds, making the adsorption method efficient and viable technique for treating water containing such contaminants.
A Norwegian seaweed utopia? Governmental narratives of coastal communities, upscaling, and the industrial conquering of ocean spaces
Authors: Albrecht Moritz 
Published: August 2023

AbstractAlgae-based biomass occupies a prominent role in policy narratives for a more sustainable future situated between Blue Growth Strategies and European (Blue) bioeconomy development. Especially in Norway, the developing seaweed farming sector is portrayed as a novel bioresource sector entailing an array of benefits to remediate global as local environmental and socio-economic challenges. Accredited with massive growth potentials and framed by large-scale industrialist rhetoric with a future in conquering ocean spaces through technological fixes, the sector’s development faces multiple challenges. Additionally, the assumptive growth-centred policy narratives employed leave little room for small-scale, locally embedded alternatives called upon by many experts on sustainable and socially just blue resource governance. The paper addresses this issue by conceptualizing Norwegian seaweed farming as an assembling process with a focus on (policy) narratives as a means for governmental spatial interventions. Based on qualitative data with a focus on active Norwegian seaweed farmers’ perspectives for the sector’s current practices and future developments, the paper assesses the relations and contradictions between the optimistic key policy narratives, current sector developments, and the entrepreneur positionalities that shape the reproduction processes of this Norwegian seaweed assemblage. The paper shows that strong beliefs in extensive growth and technological solutions to tackle the fluid materialities of seaweed production are widespread among entrepreneurs. Paired with policy strategies and a development environment rooted in similar narratives, this creates a current development approach that reduces challenges to technological and administrative domains and neglects the (local) socio-economic and sustainability potential vested in alternative, small-scale approaches.
Effects of blood pressure and antihypertensive drugs on osteoarthritis: a mendelian randomized study
Authors: Zhang Yinzhen , Wang Yanpeng , Zhao Changwei , Cai Wenjun , Wang Zhengyan , Zhao Wenhai 
Published: August 2023

Abstract
Background
Previous studies have suggested that antihypertensive drugs may play a role in the treatment of osteoarthritis, but these studies may be limited by confounding factors and lead to biased results. Therefore, we conducted a Mendelian randomization study to investigate the effects of blood pressure and antihypertensive drugs on osteoarthritis.

Methods
We used published large-scale genome-wide association data and applied univariate and multivariate Mendelian randomization methods. The main analysis model was inverse variance weighting, and the reliability of the results was tested using MR-Egger intercept analysis, Cochran's Q test, and leave-one-out analysis. We comprehensively evaluated the relationship between systolic blood pressure, diastolic blood pressure, 12 antihypertensive drugs, and osteoarthritis. We also conducted verification in the independent queue of UK Biobank and built a simple linear regression model to obtain an independent comparison.

Results
We found no evidence that systolic and diastolic blood pressure significantly affected osteoarthritis. However, among antihypertensive drugs, we observed a significant positive correlation between potassium-preserving diuretics and aldosterone antagonists and all osteoarthritis (OR: 0.560, 95% CI 0.406–0.772, P = 0.0004). Sensitivity analysis showed no horizontal pleiotropy or heterogeneity, and the leave-one-out analysis demonstrated the reliability of the results. This result was replicated with nominally statistical significance in the validation cohort and exhibited significant correlation in the linear regression analysis.

Conclusions
Our study suggested that controlling the protein targets of potassium-sparing diuretics and aldosterone antagonists may have beneficial results for osteoarthritis. These findings provide valuable medication strategies for the control of hypertension in patients with osteoarthritis.
GelMA hydrogel scaffold containing curcumin-loaded solid lipid nanoparticles promotes the regeneration of degenerative discs
Authors: Wang Ying , Xu Yidi , Shang Lijun , Mao Yingji 
Published: August 2023

AbstractIntervertebral disc degenerative disease (IDD), which usually causes lower back and neck pain, is one of the most widespread musculoskeletal disorders and often causes a low quality of life. However, the surgical and conservative treatments commonly used in clinical practice are not effective. Previous studies have identified curcumin (Cur) as a potential therapeutic agent. However, its development in this regard has been limited due to its low dissolution, instability in water, and rapid metabolism. In this study, we developed a novel anti-inflammatory composite hydrogel scaffold with curcumin encapsulated in solid lipid nanoparticles and mixed it with gelatin methacrylate (GelMA) hydrogel to treat IDD. The hydrogel scaffold, denoted Cur-solid lipid nanoparticles (SLNs)/GelMA, promoted the restoration of Collagen type II (Col II) and aggrecan expression levels in vivo, indicating that the regeneration of the intervertebral discs was effective. Combined in vitro studies showed that Cur-SLNs inhibited the expression of the inflammatory factors TNF-α and IL-6. Additionally, immunofluorescence and western blotting experiments verified that Cur-SLNs regulated the recovery of Col II and aggrecan in an inflammatory environment and promoted the metabolic homeostasis of the extramedullary cell matrix. In conclusion, this study provides a new strategy to promote IDD regeneration, which brings new application prospects.
Central nervous system disorders after use of dolutegravir: evidence from preclinical and clinical studies
Authors: Jakimiuk Alicja , Piechal Agnieszka , Wiercińska-Drapało Alicja , Nowaczyk Alicja , Mirowska-Guzel Dagmara 
Published: August 2023

AbstractThe evaluation of dolutegravir based on available preclinical and clinical studies reveals a risk of central nervous system (CNS) disorders associated with long-term use of the drug. The available literature on the pharmacokinetics of the drug, including its penetration of the blood–brain barrier, was reviewed, as well as clinical trials assessing the incidence of adverse effects in the CNS and the frequency of its discontinuation. This paper also summarizes the impact of factors affecting the occurrence of CNS disorders and indicates the key role of pharmacovigilance in the process of supplementing knowledge on the safety of drugs, especially those that are newly registered.
Recovery trajectories of IQ after pediatric TBI: A latent class growth modeling analysis
Authors: Narad Megan E. , Smith-Paine Julia , Cassedy Amy , LeBlond Elizabeth , Taylor H. Gerry , Yeates Keith Owen , Wade Shari L. 
Published: August 2023

AbstractObjective:To identify latent trajectories of IQ over time after pediatric traumatic brain injury (TBI) and examine the predictive value of risk factors within and across recovery trajectories.Method:206 children ages 3–7 years at injury were included: 87 TBI (23 severe, 21 moderate, 43 complicated mild) and 119 orthopedic injury (OI). We administered intelligence tests shortly after injury (1½ months), 12 months, and 6.8 years postinjury. Latent class growth modeling was used to identify latent subgroups. Separate models examined verbal and nonverbal IQ recovery trajectories following TBI versus OI. Variables included: age at injury, sex, race, socioeconomic status, injury severity, quality of the home environment, family functioning, and parenting style.Results:Both the TBI and OI analyses yielded different growth models for nonverbal (k = 3) and verbal IQ (k = 3). Although all models resulted in 3 latent classes (below average, average, and aboveaverage performance); trajectory shapes, contributors to class membership, and performance within each class varied by injury group and IQ domain. TBI severity was associated with class membership for nonverbal IQ, with less severe injuries associated with higher IQ scores; however, TBI severity did not influence verbal IQ class membership. Parenting style had a more prominent effect on verbal and nonverbal IQ within the TBI than OI trajectories.Conclusions:Findings suggest TBI severity is related to recovery trajectories for nonverbal but not verbal IQ and parenting style has stronger effects on recovery in TBI than OI. Results highlight the importance of parental factors on long-term recovery after TBI.
Estimating the Socioeconomic Impacts of Flooding on Regional Economies With a Computable General Equilibrium Model
Authors: Parent Olivier , Hofe Rainer vom , Oh Seunghoon , Ervin Paul , Khalid Md Atikul , Yeghiazarian Lilit 
Published: August 2023

AbstractThe growing number of flood events in urban areas is causing far‐reaching economic losses and social disruptions. To implement suitable flood risk management strategies and measures for flood prevention and mitigation, it is paramount to adequately assess economy‐wide losses associated with potential flood events. The assessment of potential flood damage in the USA relies significantly on the Federal Emergency Management Agency (FEMA) Hazus Flood Model. A primary requirement to reduce uncertainty is to empirically gather user input data. Consequently, there is a need to integrate publicly accessible business data for accurate evaluation of losses in business activities. We present a novel approach for estimating both the direct losses in business activities during a flood and the total economy‐wide impact that arise from these disruptions. First, we integrate the FEMA Hazus Flood Model with Reference Solutions business‐level data to estimate the reduction in business activities (i.e., direct losses) following a 100‐year flood event in New Hanover County, North Carolina. Second, we estimate the broader economy‐wide impact these business activity losses have on total industry output, employment, value‐added and household income using a regional computational general equilibrium model. The advantage of our approach is the easy replicability of the business loss estimation process for US cities and regions of interest, which, when used in a follow‐up economic impact study, leads to estimating the total economy‐wide losses in economic activities. Policy makers relying solely on direct physical and economic damages would, by ignoring indirect losses, underestimate the benefits of investing in flood mitigation and protection.
Intensification of Mesoscale Convective Systems in the East Asian Rainband Over the Past Two Decades
Authors: Li Puxi , Song Fengfei , Chen Haoming , Li Jian , Prein Andreas F. , Zhang Wenxia , Zhou Tianjun , Zhuang Moran , Furtado Kalli , Muetzelfeldt Mark , Schiemann Reinhard , Li Chao 
Published: August 2023

AbstractAs one of the major producers of extreme precipitation, mesoscale convective systems (MCSs) have received much attention. Recently, MCSs over several hotpots, including the Sahel and US Great Plains, have been found to intensify under global warming. However, relevant studies on the East Asian rainband, another MCS hotpot, are scarce. Here, by using a novel rain‐cell tracking algorithm on a high spatiotemporal resolution satellite precipitation product, we show that both the frequency and intensity of MCSs over the East Asian rainband have increased by 21.8% and 9.8% respectively over the past two decades (2000–2021). The more frequent and intense MCSs contribute nearly three quarters to the total precipitation increase. The changes in MCSs are caused by more frequent favorable large‐scale water vapor‐rich environments that are likely to increase under global warming. The increased frequency and intensity of MCSs have profound impacts on the hydroclimate of East Asia, including producing extreme events such as severe flooding.
Sea‐Ice Impacts Inter‐Annual Variability of Phytoplankton Bloom Characteristics and Carbon Export in the Weddell Sea
Authors: Giddy I. S. , Nicholson S.‐A. , Queste B. Y. , Thomalla S. , Swart S. 
Published: August 2023

AbstractThe Antarctic Marginal Ice Zone (MIZ) accounts for 15% of the Southern Ocean's primary production (PP), but limited data has hindered understanding of its variability and connection to carbon export. Using a combination of gliders, biogeochemical Argo floats and satellite observations in the northeast Weddell Sea, we show that years with more sea‐ice formation over winter are followed by more intense phytoplankton blooms (∼15% greater daily PP) and export to 100 m (∼50% higher daily carbon export) the following summer. However, the carbon export beyond the deepest winter mixed layer did not vary in proportion to PP, suggesting different drivers of carbon export at depth compared to surface waters. Furthermore, across the entire MIZ, the response of blooms to sea‐ice volume was spatially variable, indicating the need to consider spatial heterogeneity in the response of the biological carbon pump to future sea‐ice changes.
Perturbation of Tropical Stratospheric Ozone Through Homogeneous and Heterogeneous Chemistry Due To Pinatubo
Authors: Peng Yifeng , Yu Pengfei , Portmann Robert W. , Rosenlof Karen H. , Zhang Jiankai , Liu Cheng‐Cheng , Li Jiangtao , Tian Wenshou 
Published: August 2023

AbstractThe Pinatubo eruption in 1991 injected 10–20 Tg SO2 into the stratosphere, which formed sulfate aerosols through oxidation. Our modeling results show that volcanic heating significantly perturbs the heterogeneous and homogeneous chemistry including NOx and HOx catalytic cycles in the tropical stratosphere. The simulated tropical chemical ozone tendency is positive at 20 mb while negative at 10 mb in the tropics. The simulated ozone chemical tendency is of the same magnitude as the dynamical ozone tendency caused by the accelerated tropical upwelling, but with the opposite sign. Our study finds that the tropical ozone chemical tendency due to homogeneous chemistry becomes more important than heterogeneous chemistry 3 months after eruption. Sensitivity simulations further suggest that the tropical ozone tendency through heterogeneous chemistry is saturated when the injected amount exceeds 2 Tg.
Decoupled Zircon Si–O Isotopes Tracing the Supracrustal Silicification and Komatiitic‐Derived Fluids in the Source of TTGs
Authors: Lei Kai , Wang Hao , Wang Xiaolei , Zhang Qing , Li Xian‐Hua 
Published: August 2023

AbstractThe tonalite–trondhjemite–granodiorite suites (TTGs) are key components of the Archean continental crust and therefore crucial to the understanding of the evolution of the early Earth. Here, we present in situ zircon Si–O isotope data of TTGs from Barberton. Results show that the 3.45–3.42 Ga (Group 1) and 3.24–3.23 Ga TTGs (Group 2) have elevated δ30Simelt values but mantle‐like δ18Ozrc values, whereas the 3.23–3.22 Ga TTGs (Group 3) have coupled elevated δ30Simelt and δ18Ozrc values relative to mantle‐derived rocks. We suggest that the Group 1 and 2 TTGs had a silicified source that was affected by low‐δ18O fluid released from the komatiitic rocks. The low‐δ18O fluid decreased the δ18Ozrc values of Group 1 and 2 TTGs but had negligible influence on their δ30Simelt values. The Group 3 TTGs were generated solely from the silicified source, as the low‐δ18O fluid had become exhausted at that time.