bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adjacent Fu’s subcutaneous needling as an adjunctive healing strategy for diabetic foot ulcers: Two case reports
Authors: Qi Fei , Huang Huiyi , Cai Yanyan , Fu Zhonghua 
Published: December 2022

Rationale:
Diabetic foot ulcers (DFUs) present with different grades of ischemia and infection and are associated with high mortality and disability rates with little effective treatment. We used Fu Subcutaneous Needling (FSN) to treat 2 cases with DFUs and achieved satisfactory results.

Patient concerns:
Two cases of DFUs showed poor recovery after conventional wound care treatment, and case 2 was confronted with the risk of amputation.

Diagnosis:
Two patients with history of diabetes were diagnosed with DFUs, presenting with lower leg and foot ulcers.

Interventions:
Case 1 received 6 sessions of FSN treatment in 8 days, and case 2 received 10 sessions of FSN treatment in 14 days.

Outcomes:
Case 1 completely healed from a 1 × 0.5-cm blister and a 0.5 × 0.5-cm ulcer of the right lower leg 14 days after the first FSN treatment. The ulcer area of the left foot in case 2 decreased from 6 × 7 cm to 4 × 3.5 × 0.2 cm. Three months of follow-up revealed full wound closure.

Lessons:
FSN is effective for healing with DFUs, and it may be used as an adjunctive healing strategy for DFUs patients when conventional treatments such as infection, glycemic control, and local ulcer care are not available.
Invigorating spleen, replenishing qi and tonifying kidney method treatment of traditional Chinese medicine for myasthenia gravis: A protocol for systematic review and meta-analysis
Authors: Liu Miao , Wang Hongan , Lv Zhiguo , Lu Jing , Zhang Dongmei , Zhu Zhiyue , Wu Chunwei , Tian Ye , Song Chaoqun , Wu Tong , Liu Li , Chen Xinzhi 
Published: December 2022

Background:
Myasthenia gravis (MG) is an autoimmune disease related to the production of autoantibodies. It is mediated by antibodies against acetylcholine receptor (AChR), muscle specific kinase (MuSK) or other AChR related proteins in the postsynaptic muscle membrane, which interfere with the transmission of signals at the neuromuscular junction, resulting in clinical symptoms of skeletal muscle weakness and fatigue, leading to the occurrence and development of MG. At present, the incidence rate of Mg is increasing year by year. At present, the method of invigorating spleen, replenishing qi and tonifying kidney in traditional Chinese medicine has been widely used in the clinical treatment of MG, and the effect is good. The purpose of this study was to systematically evaluate the efficacy and safety of the method of invigorating the spleen, supplementing qi and tonifying the kidney in the treatment of MG.

Methods:
We will search from the following eight databases: PubMed, Cochrane Library, EMBASE, Web of Science, CNKI, Sinomed, Wanfang, and Vip. All randomized controlled trial (RCT) literature has been searched and classified since the establishment of the database to date. In this study, two researchers independently screened and evaluated the quality of the retrieved literature. Cochrane risk bias assessment tool was used to evaluate the risk of bias. The meta-analysis uses RevMan 5.3 software provided by Cochrane Collaboration Network for meta analysis.

Results:
This study compared the main outcome indicators: clinical response rate, recurrence rate, incidence of adverse reactions, quantitative myasthenia gravis score (QMG). Secondary outcomes were clinical absolute score, quality of life score (QOL), levels of inflammatory factors such as IL-6, IL-10, and serum acetylcholine receptor antibody (AChR-Ab) levels.

Conclusion:
The purpose of this study was to evaluate the efficacy and safety of the method of invigorating the spleen, supplementing qi and tonifying the kidney in treating MG, and to provide evidence based medicine.
Randomized active-controlled study of a single preoperative administration of duloxetine to treat postoperative pain and numbness after posterior lumbar interbody fusion surgery
Authors: Hiroki Tadanao , Fujita Nao , Suto Takashi , Suzuki Hideo , Tsukamoto Noboru , Ohta Jo , Saito Shigeru , Obata Hideaki 
Published: December 2022

Background:
This prospective, randomized, double-blinded, active controlled trial assessed whether a single preoperative administration of 40 mg of duloxetine could decrease postoperative pain and numbness after posterior lumbar interbody fusion surgery (PLIF).

Methods:
Patients with an American Society of Anesthesiologists physical status I or II undergoing PLIF were included. At 2 hours before inducing anesthesia, patients were administered 40 mg duloxetine or 4 mg diazepam (control drug). Postoperative pain and other symptoms were evaluated on the basis of a visual analog scale, amount of fentanyl used, fentanyl dose request times, rate of use of adjunctive analgesics (diclofenac sodium or pentazocine), and lower limb numbness score (0–3) during the first 2 postoperative days.

Results:
Forty-six patients were randomly assigned to the duloxetine and diazepam groups (n = 23 each); 6 were lost to follow-up, and analysis was performed on data from 22 patients in the duloxetine group and 18 in the diazepam group. No significant differences were detected in the patient background, postoperative visual analog scale score at rest in the lumbar region and lower limbs, fentanyl use, rate of analgesic adjuvant use, or incidence of side effects. The numbness score in the lower limbs, however, was significantly lower in the duloxetine group.

Conclusion:
A single preoperative 40-mg dose of duloxetine did not improve postoperative pain after PLIF, but did improve lower limb numbness. Duloxetine may suppress neuropathic pain-like symptoms after PLIF surgery.
Transcutaneous electrical acupoint stimulation for the prevention of perioperative neurocognitive disorders in geriatric patients: A systematic review and meta-analysis of randomized controlled trials
Authors: Li Shuying , Jiang Hailun , Liu Wei , Yin Yu , Yin Chunsheng , Chen Hao , Du Yuzheng , Zhao Qi , Zhang Yi , Li Chen 
Published: December 2022

Background:
To evaluate whether transcutaneous electrical acupoint stimulation (TEAS) decreases rates of perioperative neurocognitive disorders (PND) when used as an adjuvant method during perioperative period in geriatric patients since the new definition was released in 2018.

Methods:
Six databases [Chinese National Knowledge Infrastructure, VIP Database for Chinese Technical Periodicals, WanFang Database, PubMed, EMBASE, and Cochrane Library] were systematically searched. Data analysis was performed using RevMan 5.4.1 software (Copenhagen: The Nordic Cochrane Centre, the Cochrane Collaboration, 2020). Risk ratios (RR) with 95% confidence interval were calculated using a random effects model. Quality of evidence was assessed using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) approach.

Results:
13 randomized clinical trials (999 patients) in total were included. TEAS had positive effects on preventing the incidence of PND (RR: 0.43; 0.31, 0.61; P < .001; low certainty) [postoperative delirium within 7 days (RR: 0.39; 0.26, 0.59; P < .001), delayed neurocognitive recovery within 3 months (RR: 0.51; 0.33, 0.78; P = .002)]. TEAS could also improve the scores of the confusion assessment method (CAM) (Mean difference: −1.30; −2.14, −0.46; P = .003; low certainty). Limited evidence suggested that TEAS could reduce the serum levels of biochemical indicator (S100β) (SMD = −1.08, −1.67, –0.49, P < .001; I

2
= 83%; very low certainty) as well as anesthetic requirements (remifentanil) (SMD: −1.58; −2.54, −0.63; P = .001; I

2
= 87%; very low certainty). Subgroup analysis indicated that different protocols of TEAS had significant pooled benefits (TEAS used only in surgery and in combination with postoperative intervention) (RR: 0.45; 0.31, 0.63; P < .001). Acupoint combination (LI4 and PC6) in the TEAS group had more significantly advantages (RR: 0.34; 0.17, 0.67; P = .002). TEAS group had a lower incidence of PND in different surgery type (orthopedic surgery and abdominal surgery) (RR: 0.43; 0.30, 0.60; P < .001), as well as with different anesthetic modality (intravenous anesthesia and intravenous and inhalational combined anesthesia) (RR: 0.38; 0.23, 0.61; P < .001).

Conclusion:
In terms of clinical effectiveness, TEAS appeared to be beneficial for prophylaxis of PND during a relatively recent period, noting the limitations of the current evidence.
Efficacy of pharmacotherapy and non-pharmacotherapy of Alzheimer dementia: A protocol for systematic review and meta-analysis
Authors: Boongird Chitima , Tearneukit Worapong , Wongpipathpong Wannisa , McKay Gareth J , Thakkinstian Ammarin 
Published: December 2022

Background:
Alzheimer disease (AD) is the most common cause of dementia worldwide. Despite the publication of numerous systematic reviews and meta-analyses that have summarized the evidence associated with pharmacotherapies (PTs) and non-pharmacotherapies (NPTs) for the wide range of interventions available for AD treatment, their comparative safety and efficacy remains insufficiently defined.

Methods:
Systematic reviews of randomized controlled trials (RCTs) will be selected according to the following criteria: conducted in elderly patients aged 60 years or older with AD living in community or institutionalized settings, applied pairwise meta-analysis (PMA) or network meta-analysis (NMA) approaches providing pooled relative treatment effects for at least 1 pair of PTs or NPTs, and providing at least 1 of the following outcomes for patients/caregivers: cognitive, functional status, behavior, quality of life (QoL), and caregiver stress or burden. All article screening, data extraction, and risk of bias assessment will be completed independently by 2 reviewers. Relative treatment rankings will be reported with mean ranks and surface under the cumulative ranking curves.

Results and Conclusion:
We will determine the most efficacious treatment strategies for AD patients from the most highly ranked treatments. These results will help to guide clinical decision-making and improve patient care.
Are Remitters at Risk for Lower Food Security and Dietary Quality? An Exploratory Study of Mexican Immigrants in NYC
Authors: Cruz-Salazar Daniela , Hwang Neil S. , Chatterjee Shirshendu , Derose Kathryn P. , Flórez Karen R. 
Published: December 2022

AbstractRemittances confirm an immigrant’s continued social membership in their country of origin and they have been associated with improved nutritional outcomes among those who receive them. Yet, the relationship between remittances and nutrition outcomes of remitters is not well understood. We use data from 81 Mexican immigrants living in the Bronx, New York City (“NYC”), collected in 2019 to examine the relationship among remittances, gender, food security and dietary quality. After controlling for sociodemographic and immigration-related factors, we did not find a statistically significant (p<0.1) relationship between sending remittances and food insecurity; however, we did find that women remitters had higher odds than men remitters of having low dietary quality (p<0.064). We also found that a higher Body Mass Index (“BMI”) was associated with higher odds of experiencing low and very low food security (p<0.068). Further research with nationally representative data is needed to investigate the full extent of association between remittances and nutritional outcomes of remitters.
KNOWLEDGE AND UPTAKE OF TETANUS TOXOID VACCINE AND ASSOCIATED FACTORS AMONG REPRODUCTIVE AGE GROUP WOMEN IN HAYK TOWN SOUTH WOLLO, ETHIOPIA, CROSS-SECTIONAL STUDY
Authors: Gelaw Tiruset , Ayalew Sindu , eyene Kassaw 
Published: December 2022

AbstractBackgroundTetanus is an acute, often fatal, disease caused by an exotoxin and highly potent neurotoxin, tetanospasm, Tetanus is a preventable disease by tetanus toxoid immunization, which is usually given to the reproductive women at the age between (15-44) years in order to protect both mother and newborn in order to prevent maternal and neonatal tetanus For lifelong protection from tetanus a woman needs a total of five tetanus toxoid dosesObjectiveTo assess the level of knowledge uptake and associated factors of completing tetanus toxoid vaccine among reproductive age women in Hayk town, SouthWollo, Amhara, Ethiopia in 2020.Methods and materialsA community based cross-sectional study conducted in Hayk town, South Wollo Amhara, Ethiopia, from November to December on 2020. Data collected using structured and pretested questionnaire, entered in to Epi Data version 3.1 and exported to statistical package for social science version 25.0 for analysis.ResultMagnitude of uptake of TT2 immunization at Hayk town was 71.2%, have taken at least two doses of TT. But only 35(8.5%) had completed 5 doses of TT according to EPI schedule. Nearly half of 182(44%) of women in the reproductive age group had knowledge on complete TT5 immunization. Educational status, having sort of info on TT5 and knowledge about TT are significantly associated factors for full dose of TT according to EPI schedule.ConclusionFair proportions of women had uptake of TT2, but very low proportion for complete dose of TT5 according to expanded program on Immunization. Most of study participants have inadequate knowledge on TT vaccine. Educational status, having sort of info on TT5 and knowledge about TT are significantly associated factors for completing full dose of TT according to EPI schedule.
Alcohol related consequences and disparate outcomes in college students at a Hispanic Serving Institution
Authors: Kepner Wayne , Ayala Guadalupe X. , Lange James , Elder John 
Published: December 2022

ObjectiveExamine the relationship between alcohol consumption and alcohol related consequences (ARCs) for college students at a Hispanic Serving Institution (HSI).ParticipantsRandom sample of 375 students at a large university in the pacific south-west.MethodsCross sectional study using an online version of the ACHA-NCHA II survey. Chi-square tests and stepped logistic regression models were conducted to explore the relationship between race/ethnicity and the experience of any alcohol-related consequence, adjusting for covariates.ResultsAmong heavy drinkers, Hispanic students, compared to White students, were 65.9% less likely to report one or more ARC (OR= 0.34, 95%CI = 0.15, 0.79).ConclusionsGiven the severity of alcohol related consequences in the college population, the potential protective environmental effects of attending a HSI warrant further study.
Analysis of structural network topology alterations in autism and its relationship with autism severity
Authors: Jeyapratap Abhishek S. , Parker Drew , Yerys Benjamin E. , Verma Ragini , Osmanlıoğlu Yusuf 
Published: December 2022

ABSTRACTAutism Spectrum Disorder (ASD) is a public health concern ranging along a continuum of severity. The neurobiological motives behind ASD have been widely explored with reports about aberrant brain anatomy and functional connectivity. However, research on the underlying structural connectivity alterations is limited. We propose the application of a novel connectomic measure called Network Normality Score (NNS) to identify brain abnormalities and quantity topological dissimilarities in individuals with ASD. We show that the network topology of structural connectivity is altered in ASD brains relative to healthy controls at the global and system levels. We demonstrate that structural connectivity differences are more pronounced in certain subnetworks. Finally, we quantify the association between network similarity and behavioral autism severity to show the efficacy of NNS as a neuroimaging measure.
Cell wall strengthening by phenylpropanoid dehydrodimers during the plant hypersensitive cell death
Authors: Kanawati Basem , Bertic Marko , Moritz Franco , Habermann Felix , Zimmer Ina , Mackey David , Schmitt-Kopplin Philippe , Schnitzler Jörg-Peter , Durner Jörg , Gaupels Frank 
Published: December 2022

ABSTRACTInfection of Arabidopsis with avirulentPseudomonas syringaeand exposure to nitrogen dioxide (NO2) both trigger hypersensitive cell death (HCD) that is characterized by the emission of bright blue-green (BG) autofluorescence under UV illumination. The aim of our current work was to identify the BG fluorescent molecules and scrutinize their biosynthesis and functions during the HCD. Compared to wild-type (WT) plants, the phenylpropanoid-deficient mutantfah1developed normal HCD except for the absence of BG fluorescence. Ultrahigh resolution metabolomics combined with mass difference network analysis revealed that WT but notfah1plants rapidly accumulate dehydrodimers of sinapic acid, sinapoylmalate, 5-OH-ferulic acid, and 5-OH-feruloylmalate during the HCD. FAH1-dependent BG fluorescence appeared exclusively within dying cells of the upper epidermis as detected by microscopy. Saponification released dehydrodimers from extracted cell wall material. Collectively, our data suggest that HCD induction leads to the formation of free BG fluorescent dehydrodimers from monomeric sinapates and 5-hydroxyferulates. Reactive oxygen species from de-regulated photosynthesis likely contribute to the radical-radical coupling. The formed dehydrodimers move from upper epidermis cells into the apoplast where they esterify and thereby cross-link cell wall polymers. Both, free as well as wall-bound phenylpropanoid dehydrodimers are defense-related compounds in Arabidopsis. We propose that other plants also employ dehydrodimers of highly abundant phenylpropanoids for rapid defense against pathogen attack.
Metabolic Drivers of Dysglycemia in Pregnancy: Ethnic-Specific GWAS of 146 Metabolites and 1-Sample Mendelian Randomisation Analyses in a UK Multi-Ethnic Birth Cohort
Authors: Fuller Harriett , Iles Mark M , Moore J. Bernadette , Zulyniak Michael A. 
Published: December 2022

AbstractGestational diabetes mellitus (GDM) is the most common pregnancy complication worldwide and is associated with short- and long-term health implications for both mother and child. Prevalence of GDM varies between ethnicities, with South Asians (SAs) experiencing up to three times the risk compared to white Europeans (WEs). This study aimed to evaluate the causal role of metabolic characteristics in the ethnic-associated differences in gestational dysglycemia.A one-sample Mendelian Randomisation (MR) was performed separately on 3688 SA and 3354 WE women (<28thweek of pregnancy) from the Born in Bradford (BiB) cohort for 146 metabolites exposures for the outcomes of fasting glucose and 2-hr post glucose (P ≤ 1 x 10-5was considered significant). Additional GWAS and MR analyses on 22 composite measures of metabolite classes were also conducted.Through an extensive GWAS analysis this study identified 15 novel genome-wide significant (GWS) SNPs associated with tyrosine in theFOXNandSLC13A2genes and 1 novel GWS SNP (currently in no known gene) associated with acetate in SAs. Through the utilisation of a MR analysis, 14 metabolites were found to be associated with postprandial glucose in WEs, while in SAs a distinct panel of 11 metabolites were identified. Furthermore, in WEs, cholesterols were most the common metabolite associated with dysglycemia, while in SAs saturated fatty acids were most common. Furthermore, in SAs a composite measure of the fatty acid class was also found to associate with 2-hour post glucose.The presence of ethnic-specific causal relationships between a comprehensive set of metabolites and postprandial glucose measures (fasting glucose and 2-hour post glucose) in mid-pregnancy has been established in a UK SA and WE population. Future work should aim to investigate the biological mechanisms of metabolites on GDM risk and inform ethnically tailored GDM prevention strategies are required.
Sequential Bilateral Accelerated Theta Burst Stimulation in Adolescents With Suicidal Ideation Associated With Major Depressive Disorder: Protocol for a Randomized Controlled Trial
Authors: Yuruk Deniz , Ozger Can , Garzon Juan F. , Leffler Jarrod M. , Shekunov Julia , Vande Voort Jennifer L. , Zaccariello Michael J. , Nakonezny Paul A. , Croarkin Paul E. 
Published: December 2022

AbstractBackgroundSuicide is a leading cause of death in adolescents worldwide. Previous research findings suggest that suicidal adolescents with depression have pathophysiological dorsolateral prefrontal cortex (DLPFC) deficits in γ-aminobutyric acid neurotransmission. Interventions with transcranial magnetic stimulation (TMS) directly address these underlying pathophysiological deficits in the prefrontal cortex. Theta burst stimulation (TBS) is newer dosing approach for TMS. Accelerated TBS (aTBS) involves administering multiple sessions of TMS daily as this dosing may be more efficient, tolerable, and rapid acting than standard TMS.Methods:This is a randomized, double-blind, sham-controlled trial of sequential bilateral aTBS in adolescents with MDD and suicidal ideation. Three sessions are administered daily for 10 days. During each session, continuous TBS is administered first to the right DPFC, in which 1,800 pulses are delivered continuously over 120 seconds. Then intermittent TBS is applied to the left DPFC, in which 1,800 pulses are delivered in 2-second bursts and repeated every 10 seconds for 570 seconds. The TBS parameters were adopted from prior research, with 3-pulse, 50-Hz bursts given every 200 ms (at 5 Hz) with an intensity of 80% active motor threshold. The comparison group will receive 3 daily sessions of bilateral sham TBS treatment for 10 days. All participants will receive the standard of care for patients with depression and suicidal ideation including daily psychotherapeutic skill sessions. Long-interval intracortical inhibition (LICI) biomarkers will be measured before and after treatment. Exploratory measures will be collected with TMS and electroencephalography for biomarker development.DiscussionThis is the first known randomized controlled trial to examine the efficacy of sequential bilateral aTBS for treating suicidal ideation in adolescents with MDD. Results from this study will also provide opportunities to further understand the neurophysiological and molecular mechanisms of suicidal ideation in adolescents.Trial registrationInvestigational device exemption (IDE) Number: G200220, ClinicalTrials.gov (ID:NCT04701840). Registered August 6, 2020.https://clinicaltrials.gov/ct2/show/NCT04502758?term=NCT04701840&draw=2&rank=1