bluuebunny/crossref_metadata_2025_split huggingface dataset:
Abstract IA024: The role of consortia building the paradigm of blood-based early cancer detection
Authors: Clarke Christina A. 
Published: January 2023

Abstract
A longstanding challenge in public health includes developing and disseminating innovative solutions for earlier detection, screening, and diagnosis of cancers. The advent of novel technologies for blood-based cancer detection have raised entirely new questions for how these tests should be evaluated and adopted. Diverse stakeholder collaboration is required to flesh out and resolve some of these questions and challenges. In this presentation, we will dig into the ongoing activities of two active consortia: the Multi-Cancer Early Detection (MCED) Consortium and BLOODPAC Screening and Early Detection Working Group, both of which have been set forth as collaborative multi-stakeholder venues for developing shared frameworks, aggregating supporting data, and accelerating evaluation.
Citation Format: Christina A. Clarke. The role of consortia building the paradigm of blood-based early cancer detection. [abstract]. In: Proceedings of the AACR Special Conference: Precision Prevention, Early Detection, and Interception of Cancer; 2022 Nov 17-19; Austin, TX. Philadelphia (PA): AACR; Can Prev Res 2023;16(1 Suppl): Abstract nr IA024.
Abstract P023: The impact of limited English proficiency and healthcare access on HPV vaccine uptake in the United States
Authors: Talip Marian F. , Casimir Trinity , Hurst Jillian H. , Rocke Daniel J. , Watts Tammara L. , Cannon Trinitia Y. , Boakye Eric Adjei , Osazuwa-Peters Nosayaba 
Published: January 2023

Abstract
Background: Limited English proficiency (LEP) impacts patient-provider communication and access to healthcare, both of which are also associated with human papillomavirus (HPV) vaccine uptake. We examined the association between LEP and HPV vaccine uptake among parents/guardians of adolescents and young adults eligible for the HPV vaccination in the United States. Methods: Using a cross-sectional study design, we analyzed nationally representative data from the National Health and Nutrition Examination Survey between 2017 and 2020 (n = 3,993). Outcome of interest was HPV vaccine uptake, defined as initiation (at least one dose), or completion (at least two or three doses). LEP was defined as completing the questionnaire in a language other than English and/or using an interpreter. Logistic regression models estimated odds of HPV vaccine uptake based on LEP, adjusting for covariates, including age, sex, healthcare access, income, race, and ethnicity. Analyses were stratified into groups aged 9-17 and 18-26 years. Results: LEP rate was 11.2% in the 9 to 17 age-group (n = 2,584), and 8.8% in the 18-26 age-group (n = 1,409). In the adjusted analyses, we found no association between LEP and HPV vaccination in either age groups (for 9-17 years: aORinitiation = 1.10; 95% CI 0.69, 1.77; aORcompletion = 1.04; 95% CI 0.60, 1.81; and for 18-26 years: aORinitiation = 0.70; 95% CI 0.40, 1.25; aORcompletion for 18-26 years = 1.23; 95% CI 0.56, 2.70). However, we found significant associations between HPV vaccine uptake and age, sex, race/ethnicity, and healthcare access variables in both age groups. Conclusions: While language proficiency status was not significantly associated with HPV vaccine uptake in our study, we found that age, sex, race/ethnicity, and access to care are associated with HPV vaccination. This indicates the need for continued interventions targeting factors to increase access to HPV vaccine.
Citation Format: Marian F. Talip, Trinity Casimir, Jillian H. Hurst, Daniel J. Rocke, Tammara L. Watts, Trinitia Y. Cannon, Eric Adjei Boakye, Nosayaba Osazuwa-Peters. The impact of limited English proficiency and healthcare access on HPV vaccine uptake in the United States. [abstract]. In: Proceedings of the AACR Special Conference: Precision Prevention, Early Detection, and Interception of Cancer; 2022 Nov 17-19; Austin, TX. Philadelphia (PA): AACR; Can Prev Res 2023;16(1 Suppl): Abstract nr P023.
Abstract P076: Contribution of the microbiome to a metabolomic signature predictive of risk for pancreatic cancer
Authors: Fahrmann Johannes F. , Irajizad Ehsan , Kenney Ana , Tang Tiffany , Vykoukal Jody , Wu Ranran , Dennison Jennifer B. , Escofet Marta Sans , Long James P. , Loftus Maureen , Chabot John A. , Kluger Michael D. , Kastrinos Fay , Brais Lauren , Babic Ana , Jajoo Kunal , Lee Linda S. , Clancy Thomas E. , Ng Kimmie , Bullock Andrea , Genkinger Jeanine M. , Maitra Anirban , Do Kim-Anh , Yu Bin , Wolpin Brian M. , Hanash Samir 
Published: January 2023

Abstract
Purpose: Emerging evidence implicates the microbiome in the development of pancreatic cancer. We investigated whether increased levels of microbial-related metabolites in circulation are associated with pancreatic cancer risk. Methods: We applied metabolomics profiling to sera from the Prostate, Lung, Colorectal and Ovarian (PLCO) Cohort to quantify and build a model based on 14 microbial-related metabolites. The study involved samples collected from 172 subjects within five years prior to diagnosis and 863 matched controls. Data from five PLCO centers were used for training and from two centers for validation and model selection. The model was subsequently tested using samples from three independent centers. The contributions of non-microbial-associated metabolites as well as CA19-9 was also assessed. Results: A 3-marker microbial-related metabolite panel yielded in the PLCO testing set an AUC of 0.64 (95% CI: 0.53-0.76) for 5-year probability of pancreatic cancer. Five additional non-microbial metabolites were identified that when combined with the microbiome panel yielded an AUC of 0.79 (95% CI: 0.71-0.88) for 5-year probability of pancreatic cancer in the PLCO testing set. The combined metabolite panel and CA19-9 yielded an AUC of 0.86 (95% CI: 0.77-0.95) for 2-year probability of pancreatic cancer in the PLCO testing set, which was improved compared to CA19-9 alone (AUC: 0.70 (95% CI: 0.57-0.82), p&lt; 0.001). Conclusion: We developed a metabolite panel derived in part from the microbiome for risk assessment of pancreatic cancer, which has relevance to prevention and early detection.
Citation Format: Johannes F. Fahrmann, Ehsan Irajizad, Ana Kenney, Tiffany Tang, Jody Vykoukal, Ranran Wu, Jennifer B. Dennison, Marta Sans Escofet, James P. Long, Maureen Loftus, John A. Chabot, Michael D. Kluger, Fay Kastrinos, Lauren Brais, Ana Babic, Kunal Jajoo, Linda S. Lee, Thomas E. Clancy, Kimmie Ng, Andrea Bullock, Jeanine M. Genkinger, Anirban Maitra, Kim-Anh Do, Bin Yu, Brian M. Wolpin, Samir Hanash. Contribution of the microbiome to a metabolomic signature predictive of risk for pancreatic cancer. [abstract]. In: Proceedings of the AACR Special Conference: Precision Prevention, Early Detection, and Interception of Cancer; 2022 Nov 17-19; Austin, TX. Philadelphia (PA): AACR; Can Prev Res 2023;16(1 Suppl): Abstract nr P076.
Abstract P077: A blood-based lipid biomarker panel for personalized risk assessment of breast cancer
Authors: Fahrmann Johannes F. , Irajizad Ehsan , Vykoukal Jody , Barrera Angelica Gutierrez , Dennison Jennifer B. , Wu Ranran , Arun Banu , Brewster Abenaa , Hanash Samir 
Published: January 2023

Abstract
Background: The metabolic syndrome characterized in part by obesity, hyperinsulinemia, and insulin resistance is associated with increased risk of breast cancer. However there remains a need to establish a circulating biomarker metabolic profile indicative of increased risk of breast cancer. In the current study, we performed a comprehensive metabolomics screen to identify biomarkers indicative of increased risk of breast cancer. Methods: Unbiased metabolomics profiling was conducted on an initial Development Set of plasmas collected from 353 newly diagnosed breast cancer cases and 141 controls. A deep learning neural network with 3 layers each containing 32 nodes based on 11 individual lipids corresponding to discrete lipid subclasses was built for risk prediction of breast cancer. The model was validated in an independent Test Set consisting of 79 breast cancer cases and 163 controls. Using a nested case: control matched design, we evaluated the performance of the model among body mass index (BMI) strata (≥ 30 or &lt;30kg/m2). Results: An 11-marker lipid biomarker panel encompassing lipid subclasses with known pro-inflammatory and tumor promoting roles yielded an AUC of 0.75 (95% CI: 0.70-0.79) for distinguishing breast cancer cases from controls in the Development Set. Predictive performance of the lipid panel was comparable when stratifying cases into hormone-receptor (HR) positive, HER2-positive/HR negative, and triple-negative breast cancer subtypes. The biomarker panel had an AUC of 0.74 (95% CI: 0.68-0.81) in the independent Test Set. The predictive performance of the panel was most pronounced among obese subjects (BMI ≥ 30) with an AUC of 0.81 (95% CI: 0.71-0.91) in the Test Set. Conclusions: The lipid-based biomarker panel has utility for identifying women with ‘metabolic obesity’ who are at increased risk of breast cancer and would benefit from tailored screening.
Citation Format: Johannes F. Fahrmann, Ehsan Irajizad, Jody Vykoukal, Angelica Gutierrez Barrera, Jennifer B. Dennison, Ranran Wu, Banu Arun, Abenaa Brewster, Samir Hanash. A blood-based lipid biomarker panel for personalized risk assessment of breast cancer. [abstract]. In: Proceedings of the AACR Special Conference: Precision Prevention, Early Detection, and Interception of Cancer; 2022 Nov 17-19; Austin, TX. Philadelphia (PA): AACR; Can Prev Res 2023;16(1 Suppl): Abstract nr P077.
IL9 Polarizes Macrophages to M1 and Induces the Infiltration of Antitumor Immune Cells via MIP-1 and CXCR3 Chemokines
Authors: Do-Thi Van Anh , Park Sang Min , Park Song Mi , Jeong Hye Jin , Cho Geunyoung , An Hyun-Jung , Kim Young Sang , Lee Hayyoung , Lee Jie-Oh 
Published: January 2023

Tumor-associated macrophages (TAM) are involved in tumor progression, metastasis, and immunosuppression. Because TAMs are highly plastic and could alter their phenotypes to proinflammatory M1 in response to environmental stimuli, reeducating TAMs has emerged as a promising approach to overcoming the challenges of solid cancer treatment. This study investigated the effect of IL9 on macrophage M1 polarization and verified its antitumor potential to retrain TAMs and promote chemokine secretion. We demonstrated that IL9 stimulated macrophage proliferation and polarized them toward the proinflammatory M1 phenotype in an IFNγ-dependent manner. Tumor-localized IL9 also polarized TAMs toward M1 in vivo and made them release CCL3/4 and CXCL9/10 to recruit antitumor immune cells, including T and natural killer cells, into the tumor microenvironment. Furthermore, peritoneal treatment with recombinant IL9 delayed the growth of macrophage-enriched B16F10 melanoma and 4T1 breast cancer in syngeneic mice, although IL9 treatment did not reduce tumor growth in the absence of macrophage enrichment. These results demonstrate the efficacy of IL9 in macrophage polarization to trigger antitumor immunity.Significance:These findings clarified the effect of IL9 on macrophage M1 polarization and verified its antitumor potential through retraining TAMs and chemokine secretion.
Genome-Wide Analysis of Left Ventricular Maximum Wall Thickness in the UK Biobank Cohort Reveals a Shared Genetic Background With Hypertrophic Cardiomyopathy
Authors: Aung Nay , Lopes Luis R. , van Duijvenboden Stefan , Harper Andrew R. , Goel Anuj , Grace Christopher , Ho Carolyn Y. , Weintraub William S. , Kramer Christopher M. , Neubauer Stefan , Watkins Hugh C. , Petersen Steffen E. , Munroe Patricia B. 
Published: January 2023

Background:
Left ventricular maximum wall thickness (LVMWT) is an important biomarker of left ventricular hypertrophy and provides diagnostic and prognostic information in hypertrophic cardiomyopathy (HCM). Limited information is available on the genetic determinants of LVMWT.

Methods:
We performed a genome-wide association study of LVMWT measured from the cardiovascular magnetic resonance examinations of 42 176 European individuals. We evaluated the genetic relationship between LVMWT and HCM by performing pairwise analysis using the data from the Hypertrophic Cardiomyopathy Registry in which the controls were randomly selected from UK Biobank individuals not included in the cardiovascular magnetic resonance sub-study.

Results:

Twenty-one genetic loci were discovered at
P
<5×10
−8
. Several novel candidate genes were identified including
PROX1
,
PXN
, and
PTK2
, with known functional roles in myocardial growth and sarcomere organization. The LVMWT genetic risk score is predictive of HCM in the Hypertrophic Cardiomyopathy Registry (odds ratio per SD: 1.18 [95% CI, 1.13–1.23]) with pairwise analyses demonstrating a moderate genetic correlation (r
g
=0.53) and substantial loci overlap (19/21).

Conclusions:
Our findings provide novel insights into the genetic underpinning of LVMWT and highlight its shared genetic background with HCM, supporting future endeavours to elucidate the genetic etiology of HCM.
Mechanistic Insights of the LEMD2 p.L13R Mutation and Its Role in Cardiomyopathy
Authors: Chen Ruping , Buchmann Simone , Kroth Amos , Arias-Loza Anahi-Paula , Kohlhaas Michael , Wagner Nicole , Grüner Gianna , Nickel Alexander , Cirnu Alexandra , Williams Tatjana , Maack Christoph , Ergün Süleyman , Frantz Stefan , Gerull Brenda 
Published: January 2023

Background:
Nuclear envelope proteins play an important role in the pathogenesis of hereditary cardiomyopathies. Recently, a new form of arrhythmic cardiomyopathy caused by a homozygous mutation (p.L13R) in the inner nuclear membrane protein LEMD2 was discovered. The aim was to unravel the molecular mechanisms of mutant LEMD2 in the pathogenesis of cardiomyopathy.

Methods:
We generated a Lemd2 p.L13R knock-in mouse model and a corresponding cell model via CRISPR/Cas9 technology and investigated the cardiac phenotype as well as cellular and subcellular mechanisms of nuclear membrane rupture and repair.

Results:
Knock-in mice developed a cardiomyopathy with predominantly endocardial fibrosis, left ventricular dilatation, and systolic dysfunction. Electrocardiograms displayed pronounced ventricular arrhythmias and conduction disease. A key finding of knock-in cardiomyocytes on ultrastructural level was a significant increase in nuclear membrane invaginations and decreased nuclear circularity. Furthermore, increased DNA damage and premature senescence were detected as the underlying cause of fibrotic and inflammatory remodeling. As the p.L13R mutation is located in the Lap2/Emerin/Man1 (LEM)-domain, we observed a disrupted interaction between mutant LEMD2 and BAF (barrier-to-autointegration factor), which is required to initiate the nuclear envelope rupture repair process. To mimic increased mechanical stress with subsequent nuclear envelope ruptures, we investigated mutant HeLa-cells upon electrical stimulation and increased stiffness. Here, we demonstrated impaired nuclear envelope rupture repair capacity, subsequent cytoplasmic leakage of the DNA repair factor KU80 along with increased DNA damage, and recruitment of the cGAS (cyclic GMP–AMP synthase) to the nuclear membrane and micronuclei.

Conclusions:
We show for the first time that the Lemd2 p.L13R mutation in mice recapitulates human dilated cardiomyopathy with fibrosis and severe ventricular arrhythmias. Impaired nuclear envelope rupture repair capacity resulted in increased DNA damage and activation of the cGAS/STING/IFN pathway, promoting premature senescence. Hence, LEMD2 is a new player inthe disease group of laminopathies.
LOVEWEAR: haptic clothing that allows intimate exploration for movement-impaired
Authors: Corti Emanuela , Parati Ivan , Dils Christian 
Published: January 2023

Abstract
Disabled sexuality often faces physical, political, and societal barriers. The lack of inclusivity in the sex toy market does not support an autonomous experience for impaired individuals who can’t operate toys without external assistance. LOVEWEAR is an art-science collaborative project that combines user-centered design principles with soft robotics integrated into textiles. The aim is to offer an autonomous experience through haptic feedback, allowing self-exploration of intimate sensations and sexual pleasure to females with motor impairments. A pillow interface activates an underwear garment: while caressing and touching the pillow, the wearer triggers the underwear’s inflatable inserts actuators. This transdisciplinary project used a mixed-methods research design; the objective is to promote the embedment of technology into everyday garments, to improve the wearer’s quality of life.
Deep Permutation Design: A new potential artificial intelligence-based design methodology
Authors: Terzidis Kostas , Fabrocini Filippo , Lee Hyejin , Daumard Louis 
Published: January 2023

Abstract
An artificial intelligence-based design methodology is presented based on permutations and neural networks. Elements are combined in all possible ways to form all possible design solutions and a neural network extracts the best solutions after being trained on either objective or subjective criteria. This methodology is projected to have many applications in fashion, architecture, music, storytelling, cooking, or any other design or art field that can be represented as a set of permutations.
Sound of Ikebana: Fluid Artwork Created under Zero-G Using Parabolic Flight
Authors: Tosa Naoko , Yamada Akihiro , Pang Yunian , Toba Shigetaka , Ito Azusa , Suzuki Takashi , Nakatsu Ryohei 
Published: January 2023

Abstract
The authors, led by artist Naoko Tosa, discuss their collaboration on the video artwork Sound of Ikebana, made by applying sound vibration to fluid and shooting it with a high-speed camera. To study the fluid’s shape under zero gravity the authors experimented with generating the artwork under weightlessness achieved through parabolic flight. The authors confirmed that a new shape significantly different from the one created under normal gravity is created. A three-dimensional artwork was also generated by shooting the phenomenon from multiple viewpoints.
The Interplay between Ukraine’s Domestic Legislation on Conflict and Uncontrolled Territories and its Strategic Use of ‘Lawfare’ before Russia’s 2022 Invasion of Ukraine – A Troubled Nexus?
Authors: Rabinovych Maryna 
Published: January 2023

Abstract
Russia’s full-scale invasion of Ukraine on 24 February 2022 can be seen as a culmination of eight years of its aggression against Ukraine, including its annexation of Crimea in March 2014 and the control of the two ‘People’s Republics’ in Donbas. Before the invasion, the Ukrainian authorities had actively expressed their politico-legal stance on the conflict, using lawfare against the Russian Federation, e.g. at the European Court of Human Rights (ECtHR), the International Court of Justice (icj), and the International Tribunal of the Law of the Sea (itlos). In this context, the paper explores the interplay between Ukraine’s domestic legislation regarding the annexation of Crimea and Russia’s control of the People’s Republics in Donbas prior to the invasion, and Ukraine’s use of lawfare against Russia with a focus on policy and legal coherence. It is demonstrated that, while Ukraine’s lawfare strategy regarding Crimea had been in line with domestic legislation, Russia’s use of proxies in eastern Ukraine and the challenges of the Minsk peace process led to incoherence between Ukraine’s domestic laws and its use of lawfare. Though Russia’s 2022 invasion of Ukraine is a game-changer, both for Ukraine’s domestic legislation and its use of lawfare, the analysis contributes to an understanding of the nexus between domestic and international law in Ukraine prior to the invasion and explores the implications such a nexus will have for Ukraine’s future lawfare against Russia, including the most recent icj case relating to the interpretation, application, and fulfillment of the 1948 Genocide Convention.
Authoritarian Design: How the Digital Architecture on China’s Sina Weibo Facilitate Information Control
Authors: Brussee Vincent 
Published: January 2023

Abstract
This article analyzes how the governance of digital architecture, such user interfaces, algorithms, and digital features, shapes political interaction and information control in China. It discusses that, to date, studies on social media in China have mostly ignored questions of governance and digital architecture in favour of the dichotomy between censorship of content and civil activism. Instead, this article uses a combination of quantitative and qualitative methods to highlight how information control goes far beyond content management. It demonstrates that as a result of the commercial interests of the platform and regulation by the state, official party and state media accounts wield a disproportionate amount of power on the platform, as interaction among individuals is marginalized. To illustrate the real-world impact, it concludes with a preliminary analysis of Weibo’s coverage of China’s COVID-19 response.
Introduction: Charity, Relief and Humanitarianism as a Means of Maintaining Social and Political Stability in the Middle East. A Longue Durée Analysis of Actors, Categories and Practices
Authors: Naïli Falestin , Napolitano Valentina , Piraud-Fournet Pauline 
Published: January 2023

Abstract
Different forms of charity, relief and humanitarian action can be jointly approached as a means of governance and social regulation. More precisely, in the Middle East the question of stability – social and political – can be considered as a central driver for local and international actors alike. This study adopts a broad historical framework, reaching from antiquity to the present day, with the aim of approaching the subject with an openness conducive to understanding the evolution of the actors, modes of action and representations underlying aid initiatives. The longue durée approach allows to show two main specificities of the modern and contemporary Middle East: firstly, the evolution of aid practices is directly linked to human mobility, since they are connected to religious practices, commerce or violence, which led to the need to take a census, to categorise and sometimes isolate populations in order to govern and control them. Secondly, in the absence of the welfare state as the most important provider of aid, the state has until today in the Middle East much less prominence among the multiplicity of aid providers, such as the family, non-governmental, religious and community organisations.
Researching Silence: A Methodological Inquiry
Authors: Schweiger Elisabeth , Tomiak Kerstin 
Published: January 2023

The role of silence has received increasing attention in International Relations, ranging from silence as exclusion to secrecy and performance. Yet, there has been little effort to draw together a more practical, methodological inquiry into silence and how to engage with it in the research processes. This article builds on existing studies on silence and our own research experiences in conducting interviews and text analysis to interrogate the role silence plays in the research process. It aims to develop methodological tools for engaging with silence and offers a practical guide to analysing it from the data generation stage to the interpretation of silence. In doing so, it also contributes to attempts to redefine the meaning of silence in International Relations by including silence as more than an absence. Une enquête méthodologique sur le silence