bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk factors related with avascular necrosis after internal fixation of femoral neck fractures in children: a systematic review and meta-analysis
Authors: Qi Bo-Hai , Wang Xiao-Wei , Wang Xiao-Ming , Wang Huan , Yang Ya-ting , Jie Qiang 
Published: August 2023

BackgroundLess than 1% of children develop femoral neck fractures (FNF), making them uncommon. However, they may have dangerous side effects, like avascular necrosis. Even though several risk factors for postoperative avascular necrosis have been identified, there is still debate regarding them. In this investigation, a meta-analysis was performed to examine the potential causes of postoperative avascular necrosis in children with FNF.MethodsWe conducted a thorough literature search to find risk factors for avascular necrosis (AVN) after internal fixation of pediatric FNF. Until December 2022, we searched several databases, including PubMed, Embase, Cochrane Library, Web of Science, CNKI, Orthosearch, and Sinomed. Software Zotero 6.0 and Stata 17.0 were used to organise and synthesise the data. Finally, a sensitivity and publication bias test was carried out.ResultsOur study includes a total of 15 case-control studies involving 814 patients. The risk of postoperative AVN increased with age at fracture encounter (95% CI: 0.64–1.88, P = 0.0003), initial fracture displacement (95% CI: 1.87–9.54, P = 0.0005), and poor fracture reduction (95% CI:1.95–22.34, P = 0.0024) were risk factors for postoperative AVN. There was no significant relationship between gender and postoperative AVN (95% CI: 0.52–1.31, P = 0.41). Conversely, Postoperative AVN and reduction methods have no connection with each other (95% CI: 0.77–2.66, P = 0.25), procedure time (95% CI: 0.43–2.99, P = 0.16), or injury mechanism (95% CI: 0.32–2.26, P = 0.75). The incidence of post-operative AVN varies between Delbet fracture types (95% CI: 0.15–0.31, P &lt; 0.0001), with the overall trend being that the incidence of post-operative AVN is highest for type II, lowest for type IV, and close for types I and III, but it is not clear which type of fracture is the independent risk factor. Funnel plots indicate no significant publication bias.ConclusionsIn line with this study, About 26% of children who underwent surgery for a femoral neck fracture suffered postoperative AVN. The main risk factors for AVN were the child's age, the initial displacement of the fractures, and poorly reduced fractures. The risk of AVN did not significantly correlate with gender, the time of the procedure, reduction methods or the mechanism of injury. The overall trend in the incidence of postoperative AVN for the different Delbet types of fracture is that the incidence of postoperative AVN is highest for type II, lowest for type IV, and close for types I and III, but it is not clear which type of fracture is the independent risk factor.
Clinical benefit and risk of elemene in cancer patients undergoing chemotherapy: a systematic review and meta-analysis
Authors: Pan Yanhong , Wan Panting , Zhang Li , Wang Cuirong , Wang Yijun 
Published: August 2023

Introduction: Elemene injection and oral emulsion, known as elemene, have been utilized have been used in adjuvant therapy for cancer patients in China for more than 20 years. In order to evaluate the efficacy and potential risks of the treatments in cancer patients undergoing chemotherapy, a system review and meta-analysis were conducted. Additionally, the factors that may influence the outcomes were also explored.Methods: A comprehensive search was conducted across various databases including PubMed, Cochrane Library, Web of Science, EMBASE, CKNI, Wan Fang, and VIP databases. Meta-regression, subgroup, and sensitivity analyses were conducted to explore the heterogeneity. GRADE system and TSA were used to assess the strength of evidence and robustness of the results.Results: The pooled data showed that combination with elemene could improve the response rate (RR:1.48, 95%CI:1.38–1.60, p &lt; 0.00001), disease control rate (RR:1.20, 95%CI:1.15–1.25, p &lt; 0.00001), the rate of quality-of-life improvement and stability (WMD:1.31, 95% CI:1.12–1.53, p = 0.0006), immune function (CD4+/CD8+: WMD:0.33, 95% CI:0.24–0.42, p &lt; 0.00001), survival rate (1-year, RR:1.34, 95% CI:1.15–1.56, p = 0.0002; 2-year, RR:1.57, 95% CI:1.14–2.16, p = 0.006), and decrease the prevalence of most chemotherapy-induced side effects, especially leukopenia (Ⅲ-Ⅳ) (RR:0.46, 95% CI:0.35–0.61, p &lt; 0.00001), thrombocytopenia (RR:0.86, 95% CI:0.78–0.95, p = 0.003), and hemoglobin reduction (RR:0.83, 95% CI:0.73–0.95, p = 0.007). However, the administration of elemene has been found to significantly increase the incidence of phlebitis in patients undergoing chemotherapy (RR:3.41, 95% CI:1.47–7.93, p = 0.004). Meta-regression and subgroup analyses discovered that the outcomes were rarely influenced by CR, CT, and dosage of elemene (DE) but the cycle number of elemene (CNE) and TT were the main sources of heterogeneity.Discussion: As the treatment time and the number of cycles increased, the efficacy of the elemene combination decreased across various aspects. Thus, shorter duration and fewer cycles are recommended.
As an inhibitor of norepinephrine release, dexmedetomidine provides no improvement on stroke-associated pneumonia in mice
Authors: Zhou Miaomiao , Luo Qiong , Xu Younian 
Published: August 2023

Background: Dexmedetomidine (DEX) is commonly employed as a sedative agent to attenuate sympathetic tone and reduce norepinephrine (NE) levels. In the context of stroke-associated pneumonia (SAP), which is believed to arise from heightened sympathetic nervous system activity and elevated NE release, the precise influence of DEX remains uncertain.Methods: In this study, we generated an SAP model using middle cerebral artery occlusion (MCAO) and examined NE levels, immunological statuses in the brain and periphery, pneumonia symptoms, and extent of infarction. We aimed to determine the effects of DEX on SAP and explore the underlying. Despite its potential to reduce NE levels, DEX did not alleviate SAP symptoms or decrease the infarct area. Interestingly, DEX led to an increase in spleen size and spleen index. Furthermore, we observed a decrease in the CD3+ T cell population in both the blood and brain, but an increase in the spleen following DEX administration. The precise mechanism linking decreased CD3+ T cells and DEX’s role in SAP requires further investigation.Conclusion: The clinical use of DEX in stroke patients should be approached with caution, considering its inability to alleviate SAP symptoms and reduce the infarct area. Further research is necessary to fully understand the relationship between decreased CD3+ T cells and DEX’s influence on SAP.
Hyperspectral reflectance and agro-physiological traits for field identification of salt-tolerant wheat genotypes using the genotype by yield*trait biplot technique
Authors: Elfanah Ahmed M. S. , Darwish Mohamed A. , Selim Adel I. , Elmoselhy Omnya M. A. , Ali Abdelraouf M. , El-Maghraby Maher A. , Abdelhamid Magdi T. 
Published: August 2023

IntroductionSalinity is the abiotic obstacle that diminishes food production globally. Salinization causes by natural conditions, such as climate change, or human activities, e.g., irrigation and derange misuse. To cope with the salinity problem, improve the crop environment or utilize crop/wheat breeding (by phenotyping), specifically in spread field conditions. For example, about 33 % of the cropping area in Egypt is affected by salinity.MethodsTherefore, this study evaluated forty bread wheat genotypes under contrasting salinity field conditions across seasons 2019/20 and 2020/21 at Sakha research station in the north of Egypt. To identify the tolerance genotypes, performing physiological parameters, e.g., Fv/Fm, CCI, Na+, and K+, spectral reflectance indices (SRIs), such as NDVI, MCARI, and SR, and estimated salinity tolerance indices based on grain yield in non-saline soil and saline soil sites over the tested years. These traits (parameters) and grain yield are simultaneously performed for generating GYT biplots.ResultsThe results presented significant differences (P≤0.01) among the environments, genotypes, and their interaction for grain yield (GY) evaluated in the four environments. And the first season for traits, grain yield (GY), plant height (PH), harvest index (HI), chlorophyll content index (CCI), chlorophyll fluorescence parameter Fv/Fm, normalized difference vegetation index (NDVI) in contrasting salinity environments. Additionally, significant differences were detected among environments, genotypes, and their interaction for grain yield along with spectral reflectance indices (SRIs), e.g., Blue/Green index (BIG2), curvature index (CI), normalized difference vegetation index (NDVI), Modified simple ratio (MSR). Relying on the genotype plus genotype by environment (GGE) approach, genotypes 34 and 1 are the best for salinity sites. Genotypes 1 and 29 are the best from the genotype by stress tolerance indices (GSTI) biplot and genotype 34. Genotype 1 is the best from the genotype by yield*trait (GYT) method with spectral reflectance indices.DiscussionTherefore, we can identify genotype 1 as salinity tolerant based on the results of GSTI and GYT of SRIs and recommend involvement in the salinity breeding program in salt-affected soils. In conclusion, spectral reflectance indices were efficiently identifying genotypic variance.
Social dominance orientation, intergroup contact and belief in traditional school culture as predictors for parents’ attitudes to school segregation in the Czech Republic
Authors: Cada Karel , Gheorghiev Olga 
Published: August 2023

BackgroundThe over-representation of Roma children in segregated schools is well documented as a prevalent form of institutional racism in the Czech Republic. In the paper, we examine the inclination of parents to support school segregation.ObjectiveThe paper looks at parents’ preference for school segregation and explores its association to social dominance orientation, intergroup contacts, belief in traditional schooling and the absence of Roma children in school as proof of the school’s good quality. The first hypothesis examines an association between parents’ preference to withdraw their children from ethnically diverse schools and social dominance orientation (one’s degree of preference for inequality among social groups). The second one tests the belief in traditional schooling as a factor contributing to a preference for ethnically motivated withdrawal. The third one studies the extent to which parents’ preference to withdraw their children from ethnically diverse schools is affected by contact with Roma in their everyday life. The final hypothesis tests if parents who view Roma students as an indicator of poor education in a given school are more likely to oppose the presence of Roma students among their children’s peers.MethodsQuantitative data collection was carried out on a sample of 1,803 respondents. The target group were families with at least one child of primary school age (6–14 years). A binary logistic regression analysis was implemented to assess these relationships.ResultsThe study confirmed that ethnically motivated school withdrawal is associated with social dominance orientation, belief in traditional school culture and education. On the other hand, the role of inter-group contact in a school environment was not proved. However, the final statistical model was rather weak explaining approximately 9% of variance in segregation endorsement. The model fit improved significantly when an additional variable – absence of Roma as a sign of a good school – was added. Approximately 15% of the variance in segregation endorsement was explained by the modified set of predictors.ConclusionThe study argues that ethnically motivated school withdrawal is a result of individual attitudes and situational factors. This means that researchers interested in informal school segregation will need to consider both groups of factors.
Scoping review of the methodology of large health surveys conducted in Spain early on in the COVID-19 pandemic
Authors: Sánchez-Cantalejo Garrido Carmen , Yucumá Conde Daniela , Rueda María del Mar , Olry-de-Labry-Lima Antonio , Martín-Ruiz Eva , Higueras-Callejón Camila , Cabrera-León Andrés 
Published: August 2023

BackgroundThe use of health surveys has been key in the scientific community to promptly communicate results about the health impact of COVID-19. But what information was collected, where, when and how, and who was the study population?ObjectiveTo describe the methodological characteristics used in large health surveys conducted in Spain early on in the COVID-19 pandemic.MethodsScoping review. Inclusion criteria: observational studies published between January 2020 and December 2021, with sample sizes of over 2,000 persons resident in Spain. Databases consulted: PubMed, CINAHL, Literatura Latinoamericana y del Caribe en CC de la Salud, Scopus, PsycINFO, Embase, Sociological Abstracts, Dialnet and Web of Science Core Collection. We analyzed the characteristics of the literature references, methodologies and information gathered in the surveys selected. Fifty five studies were included.ResultsSixty percentage of the studies included had mental health as their main topic and 75% were conducted on the general adult population. Thirteen percentage had a longitudinal design, 93% used the internet to gather information and the same percentage used non-probability sampling. Thirty percentage made some type of sampling correction to reduce coverage or non-response biases, but not selection biases. Sixty seven percentage did not state the availability of their data.ConclusionsConsistent with the extensive use of non-probability sampling without any bias correction in the extraordinary setting created by COVID-19, quality population frameworks are required so that probability and representative samples can be extracted quickly to promptly address other health crises, as well as to reduce potential coverage, non-response and particularly selection biases by utilizing reweighting techniques. The low data accessibility despite the huge opportunity that COVID-19 provided for Open Science-based research is striking.
Limited evidence of a shared genetic relationship between C-reactive protein levels and cognitive function in older UK adults of European ancestry
Authors: Packer Amy , Corbett Anne , Arathimos Ryan , Ballard Clive , Aarsland Dag , Hampshire Adam , Dima Danai , Creese Byron , Malanchini Margherita , Powell Timothy R. 
Published: August 2023

IntroductionPrevious studies have shown associations between cognitive function and C-reactive protein (CRP) levels in older adults. Few studies have considered the extent to which a genetic predisposition for higher CRP levels contributes to this association.MethodsData was analyzed from 7,817 UK participants aged &gt;50 years as part of the PROTECT study, within which adults without dementia completed a comprehensive neuropsychological battery. We constructed a polygenic risk score (PRS-CRP) that explained 9.61% of the variance in serum CRP levels (p = 2.362 × 10−7) in an independent cohort. Regressions were used to explore the relationship between PRS-CRP and cognitive outcomes.ResultsWe found no significant associations between PRS-CRP and any cognitive measures in the sample overall. In older participants (&gt;62 years), we observed a significant positive association between PRS-CRP and self-ordered search score (i.e., spatial working memory).ConclusionWhilst our results indicate a weak positive relationship between PRS-CRP and spatial working memory that is specific to older adults, overall, there appears to be no strong effects of PRS-CRP on cognitive function.
HPV vaccination in Kenya: a study protocol to assess stakeholders' perspectives on implementation drivers of HPV vaccination and the acceptability of the reduced dose strategy among providers
Authors: Umutesi Grace , Oluoch Lynda , Weiner Bryan J. , Bukusi Elizabeth , Onono Maricianah , Njoroge Betty , Mecca Lucy , Ngure Kenneth , Mugo Nelly R. , Barnabas Ruanne V. 
Published: August 2023

BackgroundCervical cancer is the leading cause of cancer-related deaths among Kenyan women. Persistent infection with high-risk oncogenic Human papillomavirus (HPV) genotypes is a necessary cause of cervical cancer. HPV vaccines are safe, durable, and efficacious in preventing incident HPV infections. In Kenya, despite efforts to increase HPV vaccination, coverage remains low. We sought to assess: (1) barriers and facilitators of HPV vaccination from the perspective of adolescent girls and young women (AGYW), their guardians as well as stakeholders involved in HPV vaccine delivery, and (2) the acceptability of the single dose of the HPV vaccination among healthcare providers (HCPs).MethodsOur study is nested within the KENya Single-dose HPV-vaccine Efficacy study (KEN SHE) that sought to test the efficacy of single-dose bivalent (HPV 16/18) and single-dose nonavalent (HPV 16/18/31/33/45/52/58/6/11) vaccination. We are conducting this study in Kiambu, Nairobi, and Kisumu counties. In these counties, we are interviewing stakeholders (n = ∼25), selected based on their role in HPV vaccination at the county and national levels. Interviews are audio recorded and conducted in English or Swahili. The semi-structured interview guides were designed based on: (1) the Theoretical Domains Framework (TDF) for AGYW and guardians and (2) the Consolidated Framework for Implementation Research (CFIR) for other stakeholders. The Theoretical Framework of Acceptability (TFA) was leveraged to design the survey administered to HCPs (n = ∼309) involved in HPV vaccination. We will develop a codebook based on emerging codes from the transcripts and constructs from the TDF and CFIR. Emerging themes will be summarized highlighting similarities and differences between and within the different stakeholder groups and counties. Descriptive statistics and a χ2 test will be used to assess the distribution of responses between the different sites and regression analysis will be used to assess factors associated with high acceptability of the single-dose strategy while controlling for confounding variables.DiscussionOur study will describe key barriers and facilitators that affect HPV vaccination from the perspective of multiple stakeholders as well as insights on the perspective of HCPs towards the single-dose strategy to inform the designing of strategies to increase HPV vaccination uptake in Kenya and comparable settings.
Determinants of farmers’ willingness to pay for improved cultivars of Macrotyloma geocarpum (harms) Maréchal and Baudet in Benin and Togo
Authors: Agossou Aboègnonhou Chaldia Odette , N’Danikou Sognigbé , Fassinou Hotègni V. Nicodème , Kakpo Thomas Ange , Coulibaly Mariam , Oselebe Happiness Ogba , Achigan-Dako Enoch Gbènato 
Published: August 2023

IntroductionQuality seed is essential to satisfy food demand. This is also true for neglected crops especially those that are economically valuable such as Kersting’s groundnut (Macrotyloma geocarpum), which holds the potential to improve farmers’ livelihoods. In this study, we assessed the attributes that drove Kersting groundnut farmers’ willingness to pay for improved seeds.MethodsA total of 567 respondents were selected in the Northern Guinea and Southern Sudanian production zones in Benin and Togo using chain referral sampling, and they were then interviewed with a semi-structured questionnaire. Classification and regression trees, Ordinary Least Squared, and Tobit regression were combined to assess the relationship between the socio-demographic variables and farmers’ Willingness to Pay (WTP) and Amount they are Willing to Pay (AWTP).Results and discussionResults suggested that more than 90% of respondents involved in the production of Macrotyloma geocarpum were willing to access its improved seeds, including those who had already abandoned the cultivation of this crop due to constraints such as the very low seed yield of current cultivars, the difficulty to access seeds, and the cultivation practices. The factors which affected the amount farmers are willing to pay included the following: the low yield of current cultivars used by farmers, the expected yield of the improved variety, which should be higher than 1 ton per ha (1 t.ha−1), the socio-linguistic group affiliation, and the adoption level of improved agricultural technologies. The average amount fixed by seed companies that farmers were willing to pay for 1 kg of the improved seed was USD 5.35 but they have freely proposed to pay the average amount of USD 4.63 to access 1 kg of improved seed. The white-seeded cultivar was the most appreciated by farmers and was the most cultivated in the Northern Guinean Zone whereas the cultivation of the colored-seeded (e.g., black-seeded) cultivars was mainly noted in the Southern Sudanian Zone. Furthermore, the respondents indicated seed yield improvement and disease management as their main research needs to help increase the production of the crop. The findings of this research will help refine Macrotyloma geocarpum improvement programs to release farmer-needed varieties.
Effects of Agricultural Cropping Systems on Soil Water Capacity: The Case in Cross-Border Altai
Authors: Bondarovich Andrey , Illiger Patrick , Schmidt Gerd , Ponkina Elena , Nugumanova Aliya , Maulit Almasbek , Sutula Maxim 
Published: August 2023

Temperate grasslands are called the breadbaskets of the world. Due to most continental climate conditions, humus-rich soils have been developed. These soils are very well suited for grain production. This is why extensive conversions from natural steppe to arable land have been implemented in this biome. The Kulunda Steppe, in Southwest Siberia and Central Asia, occupies large parts of the driest regions of the Eurasian Steppe Belt. It was one of the sites of the Virgin Land Campaign realized in the former Soviet Union in the 1950s and 1960s. Intensive agricultural practices have caused significant soil degradation, mainly through humus loss and soil erosion. This results in the degradation of organic carbon, altering the physical and chemical structure of the chestnut soils and impacting their water storage capacity. Against the background of climatic changes, a further intensification of these processes and conditions is to be expected. To stabilize soil carbon and optimize moisture utilization, it is necessary to extensively introduce worldwide experiences in conservation cropping technologies (such as no-till, min-till, and direct seeding) in the area. This study aimed to determine the effects of different cropping systems on soil water storage and water availability. The study’s initial hypothesis was that the soil conservational cropping system has advantages against the traditional deep tillage (24 cm). This hypothesis was based on extensive global experience studying the effects of different agricultural management systems on soil-water balance. In 2013–2016, an experiment was conducted for the first time in the Kulunda steppe to instrumentally measure soil moisture and matrix potential at 30–60–120 cm depth under traditional and conservation technology using innovative meteorological and soil hydrological stations. Statistically significant advantages of no-till over deep tillage (24 cm) in terms of moisture retention were found, confirming the hypothesis of this study. Besides, this groundbreaking study reveals new possibilities for soil monitoring in the region. The acquired data are applicable for predictive models using remote sensing. Moreover, the results on the management effects for the soil water balance provide basic approaches to soil water monitoring, offering important data for evaluating model results and remote sensing products for the region.