bluuebunny/crossref_metadata_2025_split huggingface dataset:
Supplementary Data from The WNT10B Network Is Associated with Survival and Metastases in Chemoresistant Triple-Negative Breast Cancer
Authors: El Ayachi Ikbale , Fatima Iram , Wend Peter , Alva-Ornelas Jackelyn A. , Runke Stephanie , Kuenzinger William L. , Silva Julio , Silva Wendy , Gray Joseph K. , Lehr Stephan , Barch Hilaire C. , Krutilina Raisa I. , White Andrew C. , Cardiff Robert , Yee Lisa D. , Yang Lily , O'Regan Ruth M. , Lowry William E. , Seagroves Tiffany N. , Seewaldt Victoria , Krum Susan A. , Miranda-Carboni Gustavo A. 
Published: April 2023

<p>Supplementary Section: 1)	Seven supplementary figures and legends: A.	Supplementary figure S1: TCGA analysis of WNT10B network. B.	Supplementary figure S2: Human IHC analysis of WNT10B, HMGA2 and EZH2. C.	Supplementary figure S3: Mouse IHC analysis of HMGA2 and EZH2. D.	Supplementary figure S4: ChIP, qPCR and IB analysis on WNT10B/ï�¢CATENIN direct target genes. E.	Supplementary figure S5: Characterization of CRISPR HMGA2KO and EZH2KO cells both in vitro and in vivo. F.	Supplementary figure S6: Validation of WNT10B network on TNBC PDX tumors. G.	Supplementary figure S7: Isobologram curves of ICG-001 and Doxorubicin activity. 2)	Supplementary Material & Methods 3)	Supplementary Table 1 (ST1) qPCR primers 4)	Supplementary Table 2 (ST2) ChIP primers 5) 6)	Supplementary Table 3 (ST3) drug combinatorial index</p>
Supplemental Figure 1. from VEGF Potentiates GD3-Mediated Immunosuppression by Human Ovarian Cancer Cells
Authors: Tiper Irina V. , Temkin Sarah M. , Spiegel Sarah , Goldblum Simeon E. , Giuntoli Robert L. , Oelke Mathias , Schneck Jonathan P. , Webb Tonya J. 
Published: April 2023

<p>Ovarian cancer associated ascites contains soluble inhibitory factors. The ascites was cleared of cellular debris by centrifugation as previously described (18). (A, B) The ascites was filtered 0.2 micron filter and fractionated- f1: <5KDa; f2: 5-50KDa; f3: >50. (C) The ascites was treated with 50 μg/ml proteinase K at 37{degree sign}C for 1 hour and then incubated at 95{degree sign}C for 10min to heat inactivate the enzyme. The antigen presenting cells were treated with the clarified supernantants for 4 h at 37{degree sign}C, then washed extensively with PBS, and cocultured with NKT hybridomas for 20-24 h at 37{degree sign}C. Cytokine released (IL-2) was measured as an indication of NKT cell activation and was measured by standard sandwich ELISA.</p>
Data from Humanized Anti-Trop-2 IgG-SN-38 Conjugate for Effective Treatment of Diverse Epithelial Cancers: Preclinical Studies in Human Cancer Xenograft Models and Monkeys
Authors: Cardillo Thomas M. , Govindan Serengulam V. , Sharkey Robert M. , Trisal Preeti , Goldenberg David M. 
Published: April 2023

<div>Abstract<p><b>Purpose:</b> Evaluate the efficacy of an SN-38-anti-Trop-2 antibody–drug conjugate (ADC) against several human solid tumor types, and to assess its tolerability in mice and monkeys, the latter with tissue cross-reactivity to hRS7 similar to humans.</p><p><b>Experimental Design:</b> Two SN-38 derivatives, CL2-SN-38 and CL2A-SN-38, were conjugated to the anti-Trop-2–humanized antibody, hRS7. The immunoconjugates were characterized <i>in vitro</i> for stability, binding, and cytotoxicity. Efficacy was tested in five different human solid tumor-xenograft models that expressed Trop-2 antigen. Toxicity was assessed in mice and in Cynomolgus monkeys.</p><p><b>Results:</b> The hRS7 conjugates of the two SN-38 derivatives were equivalent in drug substitution (∼6), cell binding (<i>K</i><sub>d</sub> ∼ 1.2 nmol/L), cytotoxicity (IC<sub>50</sub> ∼ 2.2 nmol/L), and serum stability <i>in vitro</i> (<i>t</i>/<sub>½</sub> ∼ 20 hours). Exposure of cells to the ADC demonstrated signaling pathways leading to PARP cleavage, but differences <i>versus</i> free SN-38 in p53 and p21 upregulation were noted. Significant antitumor effects were produced by hRS7-SN-38 at nontoxic doses in mice bearing Calu-3 (<i>P </i>≤ 0.05), Capan-1 (<i>P </i>< 0.018), BxPC-3 (<i>P </i>< 0.005), and COLO 205 tumors (<i>P </i>< 0.033) when compared to nontargeting control ADCs. Mice tolerated a dose of 2 × 12 mg/kg (SN-38 equivalents) with only short-lived elevations in ALT and AST liver enzyme levels. Cynomolgus monkeys infused with 2 × 0.96 mg/kg exhibited only transient decreases in blood counts, although, importantly, the values did not fall below normal ranges.</p><p><b>Conclusions:</b> The anti-Trop-2 hRS7-CL2A-SN-38 ADC provides significant and specific antitumor effects against a range of human solid tumor types. It is well tolerated in monkeys, with tissue Trop-2 expression similar to humans, at clinically relevant doses, and warrants clinical investigation. <i>Clin Cancer Res; 17(10); 3157–69. ©2011 AACR</i>.</p></div>
Data from Circulating Tumor and Immune Cells for Minimally Invasive Risk Stratification of Smoldering Multiple Myeloma
Authors: Termini Rosalinda , Žihala David , Terpos Evangelos , Perez-Montaña Albert , Jelínek Tomáš , Raab Marc , Weinhold Niels , Mai Elias K. , Grab Anna Luise , Corre Jill , Vergez Francois , Sacco Antonio , Chiarini Marco , Giustini Viviana , Tucci Alessandra , Rodriguez Sara , Moreno Cristina , Perez Cristina , Maia Catarina , Martín-Sánchez Esperanza , Guerrero Camilla , Botta Cirino , Garces Juan-Jose , Lopez Aitziber , Tamariz-Amador Luis-Esteban , Prosper Felipe , Bargay Joan , Cabezudo Maria-Elena , Ocio Enrique M. , Hájek Roman , Martinez-Lopez Joaquin , Solano Fernando , Iglesias Rebeca , Paiva Artur , Geraldes Catarina , Vitoria Helena , Gomez Clara , De Arriba Felipe , Ludwig Heinz , Garcia-Guiñon Antoni , Casanova Maria , Alegre Adrian , Cabañas Valentin , Sirvent Maialen , Oriol Albert , de la Rubia Javier , Hernández-Rivas José-Ángel , Palomera Luis , Sarasa Maria , Rios Pablo , Puig Noemi , Mateos Maria-Victoria , Flores-Montero Juan , Orfao Alberto , Goldschmidt Hartmut , Avet-Loiseau Hervé , Roccaro Aldo M. , San-Miguel Jesus F. , Paiva Bruno 
Published: April 2023

<div>AbstractPurpose:<p>Early intervention in smoldering multiple myeloma (SMM) requires optimal risk stratification to avoid under- and overtreatment. We hypothesized that replacing bone marrow (BM) plasma cells (PC) for circulating tumor cells (CTC), and adding immune biomarkers in peripheral blood (PB) for the identification of patients at risk of progression due to lost immune surveillance, could improve the International Myeloma Working Group 20/2/20 model.</p>Experimental Design:<p>We report the outcomes of 150 patients with SMM enrolled in the iMMunocell study, in which serial assessment of tumor and immune cells in PB was performed every 6 months for a period of 3 years since enrollment.</p>Results:<p>Patients with >0.015% versus ≤0.015% CTCs at baseline had a median time-to-progression of 17 months versus not reached (HR, 4.9; <i>P</i> < 0.001). Presence of >20% BM PCs had no prognostic value in a multivariate analysis that included serum free light-chain ratio >20, >2 g/dL M-protein, and >0.015% CTCs. The 20/2/20 and 20/2/0.015 models yielded similar risk stratification (C-index of 0.76 and 0.78). The combination of the 20/2/0.015 model with an immune risk score based on the percentages of SLAN+ and SLAN− nonclassical monocytes, CD69<sup>+</sup>HLADR<sup>+</sup> cytotoxic NK cells, and CD4<sup>+</sup>CXCR3<sup>+</sup> stem central memory T cells, allowed patient’ stratification into low, intermediate-low, intermediate-high, and high-risk disease with 0%, 20%, 39%, and 73% rates of progression at 2 years.</p>Conclusions:<p>This study showed that CTCs outperform BM PCs for assessing tumor burden. Additional analysis in larger series are needed to define a consensus cutoff of CTCs for minimally invasive stratification of SMM.</p></div>
An adapted model of cost-related medication nonadherence among older adult patients with chronic diseases: an Iranian qualitative study
Authors: Rezaei Soheila , Peikanpour Mohammad , Zarei Leila , Mohammadnezhad Ghader , Salamzadeh Jamshid 
Published: April 2023

Abstract
Background
Following the rapid aging of population, some concerns have emerged regarding increasing demand for health care services and the consequent increase in health costs. Besides, older adult patients with chronic disease are more prone to show cost-related medication non-adherence (CRN) to cope with their medication costs. The objective of this qualitative study was to develop an adopted conceptual framework on the contextual determinants that affect the CRN in older adult patients with chronic diseases.

Methods
Problem-centered, semi-structured, in-depth, and face-to-face interviews, were conducted with healthcare informants in Iran, from Sep. 2021 to Feb. 2022. Collected data were analyzed using deductive and inductive analytic approaches and content analysis methodology was used to develop the model. This study applies to the COREQ checklist.

Results
Fifteen informants, including 8 (60%) males, with mean ± SD age of 44.4 ± 9.7 years, entered into the study. Based on the data analysis performed on the information obtained from the interview with 3 subgroups of geriatricians, health policymakers, and pharmacists, six major themes identified as determinants: 1) socio-economic factors, 2) health system-related factors, 3) healthcare provider-related factors, 4) medication-related factors, 5) disease-related factors, and 6) patient-related factors. There were also 23 minor themes which were matched with the aforementioned six major themes.

Conclusion
The final framework obtained in this qualitative study depicts CRN as an issue that is highly likely affected by six main determinants among older patients with chronic disease. Our findings emphasize that policymakers would focus on certain major themes and allocate resources to programs to improve medication therapy management in older adult patients.
A local regularization scheme of Cauchy problem for the Laplace equation on a doubly connected domain
Authors: Gong Xingtian , Yang Shuwei 
Published: April 2023

AbstractThe Cauchy problem of the Laplace equation is investigated for both exact and perturbed data on a doubly connected domain, i.e., the numerical reconstruction of the function value and the normal derivative value on a part of the boundary from the knowledge of exact or noisy Cauchy data on the remaining and accessible boundary, which is completely different from the Cauchy problem on a simply connected bounded region. We first establish the existence of a solution through the potential theory. By expressing the solution as a sum of single-layer potentials using boundary value condition, we get the integral equation systems about the density function on the boundary, and by applying local regularization scheme to the obtained integral equation systems, we get the regularization solution of the original problem. Some numerical results are presented to validate the applicability and effectiveness of the proposed method.
Działalność kobiet w ramach Obwodu ZWZ–AK Busko. Wybrane przykłady
Authors: Trzeskowska-Kubasik Karolina 
Published: April 2023

Przedmiotem niniejszego artykułu jest omówienie działalności kobiet w ramach Obwodu ZWZ–AK Busko, w południowej części Kielecczyzny. Przedstawiono różne formy ich aktywności: począwszy od łączności, przewożenia broni, amunicji i innych materiałów wojskowych, pomocy Żydom czy też służby sanitarnej. W artykule opisano również represje niemieckie wobec poszczególnych kobiet zaangażowanych w działalność podziemia.
Wspomnienia z okresu wojennego
Authors: Filipowicz Patrycja 
Published: April 2023

Niniejsze wspomnienia pochodzą z Teczki Okręgowej Delegatury Rządu na Kraj, poświęconej Antoniemu Antczakowi i przechowywanej w Archiwum Fundacji Generał Elżbiety Zawackiej w Toruniu. Zostały one zdigitalizowane i udostępnione w Kujawsko-Pomorskiej Bibliotece Cyfrowej. W 32. numerze „Biuletynu Fundacji Generał Elżbiety Zawackiej” udostępniamy je po opatrzeniu przypisami, poprawieniu błędów ortograficznych, interpunkcyjnych oraz rozwinięciu skrótów. Poprawiono tylko część niezręczności językowych, niektóre pozostawiono, aby zachować rytm oryginału.
Glosa do wyroku Sądu Najwyższego z dnia 26 stycznia 2022 r., sygn. IV KK 666/21
Authors: Chrabkowski Marek 
Published: April 2023

Glosa krytyczna do wyroku Sądu Najwyższego, który w uzasadnieniu swojego orzeczenia wyraził pogląd, że stan po użyciu środka podobnie działającego do alkoholu jest równoznaczny ze znajdowaniem się tego środka w organizmie. Autor glosy krytycznie podszedł też do tezy, że użycie środka odurzającego nie oznacza jeszcze realnego wpływu zażytego środka na zdolności psychomotoryczne kierowcy
The effect of ethnicity on the age-related changes of spinopelvic characteristics: a systematic review
Authors: Lukas Kenneth J. , Verhaegen Jeroen C. F. , Livock Holly , Kowalski Erik , Phan Philippe , Grammatopoulos George 
Published: April 2023

AimsSpinopelvic characteristics influence the hip’s biomechanical behaviour. However, to date there is little knowledge defining what ‘normal’ spinopelvic characteristics are. This study aims to determine how static spinopelvic characteristics change with age and ethnicity among asymptomatic, healthy individuals.MethodsThis systematic review followed the Preferred Reporting Items for Systematic Review and Meta-Analyses guidelines to identify English studies, including ≥ 18-year-old participants, without evidence of hip or spine pathology or a history of previous surgery or interventional treatment, documenting lumbar lordosis (LL), sacral slope (SS), pelvic tilt (PT), and pelvic incidence (PI). From a total of 2,543 articles retrieved after the initial database search, 61 articles were eventually selected for data extraction.ResultsWhen all ethnicities were combined the mean values for LL, SS, PT, and PI were: 47.4° (SD 11.0°), 35.8° (SD 7.8°), 14.0° (SD 7.2°), and 48.8° (SD 10°), respectively. LL, SS, and PT had statistically significant (p < 0.001) changes per decade at: −1.5° (SD 0.3°), −1.3° (SD 0.3°), and 1.4° (SD 0.1°). Asian populations had the largest age-dependent change in LL, SS, and PT compared to any other ethnicity per decade at: −1.3° (SD 0.3°) to −0.5° (SD 1.3°), –1.2° (SD 0.2°) to −0.3° (SD 0.3°), and 1.7° (SD 0.2°) versus 1.1° (SD 0.1°), respectively.ConclusionAgeing alters the orientation between the spine and pelvis, causing LL, SS, and PT to modify their orientations in a compensatory mechanism to maintain sagittal alignment for balance when standing. Asian populations have the largest degree of age-dependent change to their spinopelvic parameters compared to any other ethnicity, likely due to their lower PI.Cite this article: Bone Joint Res 2023;12(4):231–244.
PEMBANGUNAN EKONOMI DALAM PEMBANGUNAN SOSIAL DI INDONESIA: Analisis atas Program Bantuan Pangan Non Tunai (BPNT) di Desa Kubang Kecamatan Talun Kabupaten Cirebon
Authors: Hamdani Hamdan , Rosmawati Ninda 
Published: April 2023

Implementing the Non-Cash Food Assistance (BPNT) program, designed to help the poor, is related to the goal of sustainable economic development in the country. This research aims to identify the logical reasons for the BPNT assistance program contributing to the country's economic development. To achieve this goal, the study uses a sample of the BPNT implementation in Kubang Village, Talun Sub-district, Cirebon Regency. The implementation of the BPNT program was explored through interviews, observations, and documentation techniques supported by qualitative methods. Data were analyzed using Todaro and Smith's economic development approach. The research reveals that the program is implemented following the guidelines but faces obstacles related to the regularity of fund disbursement. The BPNT program, which aims to ensure survival by providing food and improving welfare, is conceptualized through the virtuous circle model. The implementation of non-cash assistance to the community positively impacts sustainable economic improvement in the country. Keywords: BPNT Program, Community Welfare, economic development

Pelaksanaan kebijakan program Batuan Pangan Non Tunai (BPNT) yang diselenggarakan untuk membantu masyarakat miskin berkaitan dengan tujuan pengembangan ekonomi negara secara berkelanjutan. Penelitian ini bertujuan untuk menemukan alasan logis program bantuan BPNT dalam peningkatan pembangunan ekonomi negara. Untuk mencapai tujuan tersebut, penelitian ini menggunakan sampel pelaksanaan BPNT di desa Kubang Kecamatan Talun Kabupaten Cirebon. Implementasi program BPNT ditelusuri dalam penelitian ini melalui teknik wawancara, observasi, dan dokumentasi yang didukung dengan metode kualitatif. Data dianalisis dengan menggunakan pendekatan pembangunan ekonomi Todaro dan Smith. Penelitian ini menghasilkan pelaksanaan program yang berjalan sesuai dengan pedoman dengan hambatan pada keteraturan pencairan dana. Program BPNT yang ditujukan untuk menjamin kelangsungan hidup dengan penyediaan pangan agar meningkatkan kesejahteraan dikonsep melalui model virtouos circle (lingkaran baik). Penerapan bantuan non tunai kepada masyarakat memiliki dampak peningkatan ekonomi berkelanjutan pada negara.

Kata Kunci: BPNT, Kesejahteraan Masyarakat, pembangunan ekonomi
A Trivial Source of Wonder: Some Mathematical Examples in Plato’s Dialogues
Authors: Marongiu Laura 
Published: April 2023

Abstract
The purpose of this paper is to reassess some mathematical examples in Plato’s dialogues which at a first glance may appear to be nothing more than trivial puzzles. In order to provide the necessary background for this analysis, I shall begin by sketching a brief overview of Plato’s mathematical passages and discuss the criteria for aptly selecting them. Second, I shall explain what I mean by ‘mathematical examples,’ and reflect on their function in light of the discussion on παραδείγματα outlined in the Sophist and the Statesman. Against this framework, I shall move to a close examination of specific examples drawn from the Theaetetus (154c–55d), the Republic (523c–24d), and the Phaedo (96d–97b, 100e–101d). By placing these examples in the broader context of pre-Euclidean mathematics, I shall show that their mathematical content is often less elementary than might appear at first sight. Moreover, by placing emphasis on the specific philosophical concerns that motivated their introduction, I shall argue that the examples are not merely nonsensical jokes. Even if their illustrative purpose is not always immediately clear, and even if they can sound playful and bizarre, they in fact fulfil an important function: by virtue of their power to generate wonder or confusion, they serve as exercises and act as a trigger with respect to the difficult philosophical issues they are intended to clarify.
Monitoring the state of health of first-year female students of NUPh in the 2018-2021 academic years
Authors: Anastasiia Nevelyka  , Vasyl Sutula  , Larysa Karabut  , Olga Sutula  , Alragad Raid  
Published: April 2023

The purpose of this research is to compare and determine the level of health of first-year female students of NUPh in the 2018-2021 academic years.
Material & Methods: the research involved 528 first-year female students of National University of Pharmacy (the year of entry 2018 (n=311); the year of entry 2019 (n=107); the year of entry 2020 (n=60); the year of entry 2021 (n=50)). Anthropometric parameters (body weight, standing height, hand muscle strength), physiological parameters (vital capacity of the lungs (VCL), heart rate (HR)) were determined during the examination. Functional breath-holding tests (the Stange and Hench tests) were performed, the level of physical health was determined by the method of Pyrohova, O.A., the express assessment of the level of somatic health was determined by the method of Apanasenko, H.A., and the method of assessing physical work capacity using the Ruffier test was performed. Descriptive statistics were used for the statistical analysis of the data. The comparison of average values of variable indicators was carried out using parametric methods (Student’s t-test) with the normal distribution of these signs expressed in the interval scale. All calculations were performed in StatSoft Statistica 8.1 for Windows.
Results: the data obtained in the course of the research allow us to state that the indicators of the Ruffier index are at “satisfactory” (14,1±0,3) and “average” levels (7,5±1,1). The somatic health indicator was also at the “below average” level in 2018 (4 points), it was at the “average” level (7 points) in 2019, and in 2020 and 2021, this indicator was already at the “above average” level (14 and 13 points, respectively). The level of physical health was also at the “average” level in 2018 (0,560), and in 2021 it was at the “above average” level (0,697).
Conclusions: the conducted research showed that the somatic health and physical state of first-year female students of NUPh were improving from year to year (starting from 2018), which is reflected in the health level indicator according to the method of Pyrohova, O.A. and Apanasenko, H.A., the Ruffier index, and the results of the Stange and Hench tests. The Romberg test was within the normal range. The obtained results create broad prospects for their involvement in physical culture and sports activities.
Designing Post-Digital Hybrid Workplaces
Authors: Tahsiri Mina 
Published: April 2023

As modes of work are becoming more diverse and distributed, it necessitates a revaluation of the approaches taken in designing of future workplaces. This paper argues that we are moving towards work practices that are post-digital, hybrid and collaborative in nature, requiring a closer examination of the values and requirements expected for such a workplace. In this light, the paper presents a Systematic Literature Review of research pertinent to workplace dynamics, design and management within the last decade. Two themes of ‘quality of life and satisfaction’ and ‘productivity and collaboration’ were found to be key areas of focus in literature. Collectively factors contributing to work dynamics and performance under these two themes were: crowding, degree of connectivity, degree of sociability, employee culture and perception of work, fatigue and stress, indoor environmental quality, motivation, conditions of the remote site of work, degree and culture of communication, degree of control, distractions with non-work related content, infrastructure for effective communication and interaction, mobility and flexibility, office layout and degree of spaciousness, and work and cognitive load. These raised a number of expectations for the workplace, which this paper argues renders the future workplace as a tempo-spatial phenomenon, juxtaposing constructs of the personal/individual with the social collective, dysconnectivity with connectivity and asynchrony with synchrony within a network of functions distributed across physical and digital spaces of work.