bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Italian Unitary Society of Colon-proctology (SIUCP: Società Italiana Unitaria di Colonproctologia) guidelines for the management of anal fissure
Authors: Brillantino Antonio , Renzi Adolfo , Talento Pasquale , Iacobellis Francesca , Brusciano Luigi , Monaco Luigi , Izzo Domenico , Giordano Alfredo , Pinto Michele , Fantini Corrado , Gasparrini Marcello , Visconte Michele Schiano Di , Milazzo Francesca , Ferreri Giovanni , Braini Andrea , Cocozza Umberto , Pezzatini Massimo , Gianfreda Valeria , Leo Alberto Di , Landolfi Vincenzo , Favetta Umberto , Agradi Sergio , Marino Giovanni , Varriale Massimilano , Mongardini Massimo , Pagano Claudio Edoardo Antonio , Contul Riccardo Brachet , Gallese Nando , Ucchino Giampiero , D’Ambra Michele , Rizzato Roberto , Sarzo Giacomo , Masci Bruno , Pozzo Francesca Da , Ascanelli Simona , Foroni Fabrizio , Palumbo Alessio , Liguori Patrizia , Pezzolla Angela , Marano Luigi , Capomagi Antonio , Cudazzo Eugenio , Babic Francesca , Geremia Carmelo , Bussotti Alessandro , Cicconi Mario , Sarno Antonia , Mongardini Federico Maria , Brescia Antonio , Lenisa Leonardo , Mistrangelo Massimiliano , Longo Antonio , Docimo Ludovico 
Published: May 2023

Abstract
Introduction. The aim of these evidence-based guidelines is to present a consensus position from members of the Italian Unitary Society of Colon-Proctology (SIUCP: Società Italiana Unitaria di Colon-Proctologia) on the diagnosis and management of anal fissure, with the purpose to guide every physician in the choice of the best treatment option, according with the available literature. Methods. A panel of experts was designed and charged by the Board of the SIUCP to develop key-questions on the main topics covering the management of anal fissure and to performe an accurate search on each topic in different databanks, in order to provide evidence-based answers to the questions and to summarize them in statements. All the clinical questions were discussed by the expert panel in different rounds through the Delphi approach and, for each statement, a consensus among the experts was reached. The questions were created according to the PICO criteria, and the statements developed adopting the GRADE methodology. Conclusions. In patients with acute anal fissure the medical therapy with dietary and behavioral norms is indicated. In the chronic phase of disease, the conservative treatment with topical 0.3% nifedipine plus 1.5% lidocaine or nitrates may represent the first-line therapy, eventually associated with ointments with film-forming, anti-inflammatory and healing properties such as Propionibacterium extract gel. In case of first-line treatment failure, the surgical strategy (pneumatic anal dilatation, lateral internal sphincterotomy, fissurectomy with ano-cutaneous flap), may be guided by endoanal ultrasound and anal manometry findings.
Growth, biomass production, pollutant removal capacity of Chlorella vulgaris cultivated in water polluted with nutrients (PO43- and NO3-) and heavy metal ions (Cd2+ and Pb2+); A strategy for bioremediation, CO2 utilization and simultaneous biodiesel productivity
Authors: Herath Chathurika.H. , Ganehenege Manawadevi Yasatissa Udugala 
Published: May 2023

Abstract

The objective of the work reported herein was to optimize the growth conditions, and study the bioremediation efficiency and simultaneous biomass productivity of Chlorella vulgaris grown in water contaminated with Cd2+, Pb2+ ions and nutrients (NO3− and PO43−). In this regard, Chlorella sp. were cultivated separately in the presence and absence of known concentrations of Cd2+, Pb2+ and PO43− ions in growth media containing 200 mg L− 1 of NO3− for 30 days at ~ 28°C. The biomass, % oil content and the remaining Cd2+, Pb2+ and PO43− concentrations in the growth medium in 30 days after the cultivation were determined. The results revealed that the maximum tolerable Pb2+, Cd2+, total nitrogen (TN) and total prosperous (TP) concentrations were 8 mg L− 1, 2.5 mg L− 1, 200 mg L− 1 and 10 mg L− 1, respectively for living Chlorella sp. Biomass yields (% oil content) of Chlorella sp. grown in the absence of heavy-metal ions, in the presence of Pb2+ and Cd2+ ions in the growth medium were 0.8260 g L− 1 (40.69%), 0.5551 g L− 1 (37.64% ) and 0.2896 g L− 1 (44.80%), respectively, implying no significant reduction in % oil production caused by these metal ions. The extracted bio-oil was almost free from Pb2+ and Cd2+ ions. The bioremediation efficiency of Chlorella sp. was significantly high; 77% PO43− (from 10 mg L− 1), 84% Pb2+ (from 8 mg L− 1) at pH 5 and 72.7% Cd2+ (from 2.5 mg L− 1) at pH 6.
Seawater composition variation in the eastern Sichuan evaporite formation basin: Constraint from 87 Sr/ 86 Sr and major ion compositional evidence of halite
Authors: Zhao Haitong , Zhang Xiong , Luan Jinhua , Zhang Ruigang , Zhang La , Mao Lingling , Li Changchao , Luo Xu , Hu Feng , Tian Heming , Jiang Liangmei , Dong Yi 
Published: May 2023

Abstract
The Hechuan Depression is a secondary depression in central eastern Sichuan and belongs to the Nanchong salt area (central Sichuan salt-forming zone). Palaeotethys seawater entered the secondary depression, and the subbasin gradually became shallower with tectonic changes. In this paper, the content of Sr ranges from 130 to 1316 ppm, which indicates that the water‒rock interaction time was long. The Br content of Jianglingjiang halite ranges from 108 to 191 ppm, and the Br content of the salt rock is mainly controlled by the Br concentration in concentrated seawater. The 1000Br/Cl ratio ranges from 0.18 to 0.51, which has reached the potassium mineral precipitation stage. The global environmental conditions of the Early Triassic were inherited from the late Permian with high temperature, anoxia, water stagnation and other environmental factors. The Sr isotopes of halite samples show that the ratios range from 0.708147 to 0.708256. By comparing the early Triassic SIS curve, which is consistent with the trend between the Smithian and Spathian, it can be basically determined that the evaporites were deposited in the Olenekian.
The Placental Bed in Allogenic Pregnancy: Structural and Immunohistochemical Features
Authors: Rudenko Ekaterina , Kogan Evgeniya , Demura Tatiana , Zharkov Nickolay , Protsenko Dmitry , Trifonova Natalia , Zhukova Elvira , Varentsov Viacheslav , Aleksandrov Leonid , Vekhova Ksenia , Lobanova Olga 
Published: May 2023

Abstract

Today, ART cycles using a donor egg cell are used more often, but this group of pregnancies has not been sufficiently studied in terms of detecting structural predictors of pregnancy complications caused by a special immunological relationship between the recipient mother and allogeneic blastocytes. A comprehensive clinical and morphological study of 89 allogeneic pregnancies was carried out. The morphological study was performed on placental sites biopsies taken at caesarean section (H & E, Orcein), for immunohistochemical analysis PanCK (AE1 / AE3), SMA (1A4), CD56 (123C3.D5), CD138 (B-A38), CD4 (SP35), CD25 (SP176), CD8 (SP16) were used as primary antibodies. A defect of the remodeling of the spiral arteries, including in subgroups without preeclampsia, the formation of perivascular foci of chronic inflammation were found (the accumulation of CD8 + T lymphocytes, CD56 + NK cells, CD138 + plasma cells, HLA-DR + dendritic cells). In subgroups with PE, significant changes were found for T lymphocytes (51.04 ± 2.3, 55.36 ± 11, 7 versus 37.12 ± 2.3), plasma cells (19.5 ± 3.2, 21.43 ± 8.4 versus 8.94 ± 1.2), Kruskal-Wallace test. Structural and immunohistochemical features of the allogenic placental bed may reflect the complexity of cytotrophoblast invasion and induction of maternal immunity with the formation of immune inflammation.
Myco-remediation for Chromium Stress Alleviation to Improve Maize (Zea mays L.) Physiology and Biochemistry by Seeds Bio-priming with Aspergillus niger strain PMI-1811
Authors: Aftab Amreen , Javed Sadia , Azeem Muhammad , Bashir Sarmad , Kiran Shumaila , Anwaar Nazima , Gul Saboor 
Published: May 2023

Abstract
Metal toxicity has a wide range of direct and indirect effects on plants, affecting nearly all physiological functions. Three different maize cultivars were grown under various chromium stress levels to study the response of Aspergillus niger PMI-1811 to ameliorate the adverse effects of the metal. The aim of the current study is to develop metal tolerance in cereal crops and an increase in maize productivity in Cr stress. A completely randomized design with three replicates of three maize cultivars, chromium levels, control and fungal spore suspension was used as treatment for the plants. Fungi facilitates efficient ammonia production (4.09 ± 0.373, 2.09 ± 0.644 µmol/mL), phosphate solubilization (2.48 ± 0.1 SI) and indole acetic acid (64.83 ± 2.494, 43.91 ± 1.166 µg/mL)) synthesis during in-vitro (control, stress) condition to promote plant health under chromium stress. In this study, Aspergillus niger PMI-1811 assisted the phytoremediation of chromium and improve stress tolerance in various maize (Zea mays L.) cultivars as improved plant length (45.45%) and biomass (47.29%) compared to the untreated plants. Chlorophyll (29.52%), ascorbic acid (89.66%) and other biochemical parameters were increased when compared to the uninoculated plants. Fungal inoculation reduced the accumulation of malondialdehyde (15.73%), hydrogen peroxide (13.64%) and lowered the activity of antioxidant enzymes catalase (17.86%), ascorbate peroxidase (40.43%) and peroxidase (26.32%). Moreover, fungal inoculation increased the levels of minerals K (60.46%), Ca (108.82%) and reduced Cr bioaccumulation in shoots (39.45%) and roots (46.59%). Together, the uncovering of A. niger's involvement in nutrient uptake opens up new avenues for the agricultural application. In chromium-contaminated soil A. niger could be employed for agricultural productivity and ecological restoration.
Changes in cell-free DNA after short-term palbociclib and fulvestrant treatment for advanced or metastatic hormone receptor-positive and human epidermal growth factor 2-negative breast cancer
Authors: Iwamoto Takayuki , Niikura Naoki , Watanabe Kenichi , Takeshita Takashi , Kikawa Yuichiro , Kobayashi Kokoro , Iwakuma Nobutaka , Okamura Takuho , Tada Hiroshi , Ozaki Shinji , Okuno Toshitaka , Toh Uhi , Yamamoto Yutaka , Tsuneizumi Michiko , Ishiguro Hiroshi , Masuda Norikazu , Saji Shigehira 
Published: May 2023

Abstract
Purpose
Here, we investigated the potential predictive and elucidating efficacy of cell-free DNA (cfDNA) changes on clinical outcomes and biological effects, respectively, after short-term palbociclib and fulvestrant treatment for patients with hormone receptor (HR)-positive and human epidermal growth factor 2 (HER2)-negative advanced or metastatic breast cancer (ABC).
Methods
In this secondary analysis of the Japan Breast Cancer Research Group-M07 (FUTURE) trial, blood cfDNA was obtained before palbociclib treatment and on day 15 of cycle one (28-day cycle). Target enrichment was performed using next-generation sequencing; progression-free survival (PFS) was compared based on cfDNA changes between baseline and day 15 of cycle one after combination therapy.
Results
Fifty-six patients (112 paired blood samples) were examined. The median follow-up time was 8.9 months. PIK3CA (30.4%, 17/56), FOXA1 (30.4%, 17/56), and ESR1 (28.6%, 16/56) were most frequently mutated at baseline. The number of mutated genes was significantly decreased on day 15 compared with that at baseline (paired t-test: P-value = 0.025). No significant difference was observed in PFS (decrease group, 7.9 m vs the others, 9.3 m; log-rank P-value = 0.75; hazard ratio, 1.13; 95% confidence interval, 0.53–2.41). Among patients without previous aromatase inhibitor treatment (n = 15), three (20%) had ESR1 mutations after progression to fulvestrant.
Conclusion
No significant association was observed between changes in mutated genes after short-term palbociclib and fulvestrant treatment and disease progression; a significant reduction in cfDNA mutation level was observed on day 15 of cycle one. Clinical meanings of cfDNA should be investigated in the future trials.
Distributed prescribed-time leader-follower tracking consensus control for high-order nonlinear MASs
Authors: Qiang Jiaping , Li Li , Xia Yuanqing 
Published: May 2023

Abstract
A novel distributed prescribed-time leader-follower tracking consensus control strategy is proposed for high-order nonlinear multi-agent systems (MASs) with lower triangular time-varying dynamic in directed communication topology. Firstly, a distributed prescribed-time state observer (DPTSO) is presented for follower to observe the leader’s state, transforming the consensus problem into a tracking control problem that the follower tracks the observations of the DPTSO. Then, a distributed prescribed-time controller is developed with the cascade control framework and dynamic control, which avoids differential explosion in traditional back-stepping control. Convergence time of both the DPTSO and the distributed prescribed-time controller is not only explicitly pre-specified but also determined regardless of the initial state of system and control parameters. Finally, it is demonstrated that the closed-loop systems realize prescribed-time full state leader-follower tracking consensus. Simulation results show that the method is effective and feasible.
Triple therapy for Helicobacter pylori eradication and the risk of hypoglycemia in patients with diabetes: A population-based cohort study
Authors: Chang Anne , Chang Anna , Chen Wan-Ting , Chan Lung , Hong Chien-Tai , Chien Li-Nien 
Published: May 2023

Abstract
The incidence of type 2 diabetes mellitus has risen globally, from 108 million cases in 1980 to 422 million cases in 2014. Although controlling glycemic levels in patients with diabetes is crucial, improper management can lead to hypoglycemic episodes and even potentially fatal events such as comas, seizures, life-threatening arrhythmias, and myocardial infarctions. Several antibiotics have been documented to cause hypoglycemic episodes; the use of antibiotics along with certain diabetic medications might further increase the risk of hypoglycemia. Therefore, researchers must determine which treatments against which types of infection carry a risk of inducing severe hypoglycemic events. The prevalence of H. pylori infection remains high in most countries, and the infection is often treated with triple therapy involving amoxicillin, clarithromycin, and a proton pump inhibitor (PPI). Several case reports have reported that hypoglycemia can occur when any one of them are used with patients who also take diabetes medication. Therefore, we hypothesized that patients with diabetes might experience hypoglycemic episodes when being treated with triple therapy for H. pylori infection. By analyzing medical records from Taiwan’s National Health Insurance Research Database, we found a significant association between hypoglycemia and triple therapy treatment for diabetic patients with peptic ulcer. Prescribing triple therapy to patients with diabetes and peptic ulcers significantly increase the risk of a hypoglycemic episode (adjusted odds ratio [aOR] = 1.75, 95% confidence interval [CI]: 1.64 to 1.88, P < 0.001). Similarly, the highest aOR (5.77, 95% CI 4.82 to 6.92) was found in patients with diabetes and peptic ulcers who had hypoglycemic episodes within 30 days after triple therapy treatment. Many patients with diabetes require H.pylori eradication for peptic ulcer treatment, and vigilance toward the risk of hypoglycemia in this population is thus necessary.
Suitable dissolving pulps and their impacts on solution spinning of cellulose man-made fiber
Authors: Kosan Birgit , Thümmler Katrin , Meister Frank , Römhild Katrin 
Published: May 2023

Abstract
Fiber demand and production of man-made cellulose fibers (MMCF) as Viscose rayon, Modal and Lyocell fibers increase already for a couple of years. Today they are mostly manufactured using wood dissolving pulps. But the growing fiber demand cannot be satisfied by wooden sources, only. So alternative pulps based on non-wooden materials are needed. Novel pulps, namely hemp and oil flax as pulps from biogenic residues, untreated and enzymatically treated paper pulps or recycled cotton waste, were selected in comparison to wood dissolving pulps and used for application in NMMO dissolution and solution spinning procedures. As a function of degree of polymerization (DP), molecular weight distribution (MWD) and polydispersity (PDI) three groups of pulps could be identified. Paper pulp offered the highest DP and PDI values and the broadest MWD. By an enzymatic treatment similar values as wood dissolving pulps were achieved. Pulps from biogenic residues exhibited different behavior. Hemp shives based pulp held comparable properties like wood dissolving pulps. Contrary, fiber based oil flax and hemp pulp possessed a low PDI value and tight MWD more comparable with pulp made from recycled cotton fibers. Pulp characteristics also affected the rheological behavior of spinning solutions prepared from these pulps. Concluding from all these findings it could be stated that suitable dissolving pulps have specific impacts on solution spinning of MMCF. A carefully analytical characterization by means of molecular and rheological approaches is mandatory before their use in fiber spinning activities.
Effect and mechanism of low-temperature plasma on the quantity and function of Treg and CD8+ T cells in B16-F10 melanoma-bearing mice
Authors: Shi Xingmin , Liu Na , Wang Xiangni , Wang Xiying , Liu Jinren , Cui Yixin , Xu GuiMin , Lu Jiajia , Kang Chuchu , Ma Tianyou , Wu Xili 
Published: May 2023

Abstract
Immunotherapy is effective in the treatment of melanoma due to its immunogenicity. In recent years, researchers have identified LTP is rich in active substances that can induce apoptosis in tumor cells and trigger an immune response. However, it is unclear how LTP works to antitumor by enhancing immune cell function. Therefore, the purpose of this study is to investigate the effects of direct and indirect LTP treatments on the quantity and function of Treg cells and CD8+ T cells in B16-F10 melanoma-bearing mice and their associated mechanisms. The results revealed that both direct and indirect LTP treatments were effective at inhibiting tumor growth and extending the survival of B16-F10 melanoma-bearing mice. In addition, both direct and indirect LTP treatments reduced the number of Treg cells and improved the immune function of CD8+ T cells in the spleen and tumor. Nevertheless, the indirect LTP treatment proved to be more effective than the LTP direct treatment. Mechanistic studies demonstrated that direct LTP treatment might affect the quantity and function of Treg cells and CD8+ T cells by modulating cytokine level changes. However, indirect LTP treatment might have a greater tumor immunotherapeutic potential by inhibiting the activation of key protein molecules in the IL-6/STAT3 signaling pathway and regulating cytokine level changes. In conclusion, this study reveals that LTP exerts an anti-melanoma effect by regulating the level and function of Treg cells and CD8+ T cells. This study is expected to provide new ideas for LTP anti-tumor immunotherapy.
Assessment of Quality of Palliative Care in Patients with Chronic Diseases
Authors: Kolagari Shohreh , Khoddam Homeira , Guirimand Frédéric , Mahmoudian Amaneh 
Published: May 2023

Abstract
Background and objectives:
Palliative care focuses on the physical, mental, social, and spiritual needs of patients with chronic disease to improve their quality of life. The present study aimed to assess the quality of palliative care in patients with chronic diseases in two hospitals in Gorgan, Iran.
Method
This explanatory sequential study with a mixed methods design was carried out in two quantitative and qualitative phases. In the quantitative phase, a descriptive study was carried out to collect data using the Persian version of the Quality of Palliative Care from the Patient's Perspective questionnaire. By proportional allocation of subjects and using stratified sampling, 201 patients with chronic diseases who had been admitted to hospitals affiliated with the Golestan University of Medical Sciences were enrolled. Data were described in SPSS16 using central tendency and dispersion indices. Using conventional content analysis, patients whose mean scores on the palliative care quality in the quantitative phase were within ± 1 standard deviation of the total mean score were enrolled in the qualitative phase. Then, semi-structured in-depth interviews were conducted until data saturation. The collected data were analyzed using Graneheim and Lundman's approach. Finally, the results of the two phases were combined in the discussion section.
Results
According to the results of the quantitative phase, favorable scores were given by the patients to the subscales of availability of caregivers (mean score of 0.90 out of 1), provision of care information and patient’s involvement in decision making (0.83 out of 1), pain management (0.86 out of 1), caregiver’s listening skill (0.76 out of 1), and serenity (0.70 out of 1). In addition, relatively favorable scores were given to the subscale of respect for the patients (0.47 out of 1). However, unfavorable scores were given for the psychosocial and spiritual dimensions (0.52 out of 1). The total mean score of palliative care quality was favorable (0.61 out of 1). The qualitative findings suggested six main categories: access to care information, patient involvement in decision making, support, safe care, pain management, and respect.
Conclusion
Mixing quantitative and qualitative data creates a better picture of the issue of palliative care quality. Our results could be used by healthcare managers in the study area to ultimately promote the quality of palliative care in patients with chronic diseases by addressing their physical, mental, social, and spiritual needs.
Psychometric properties of the sexual five-facet mindfulness questionnaire (FFMQ-S): validation among a community sample of Persian-speaking women.
Authors: tabatabaeeian S Asma , Kharaju Zohreh Ghanbari , Hosseinian Simin , Taheri Azadeh , Adam Françoise 
Published: May 2023

Abstract

Purpose
Sex is one of the most important relationships in people's lives, and mindfulness during sex helps to improve sex. This study validated the Persian version of the Sexual mindfulness Scale (FFMQ-S).
Methods
A sample of 668 Persian-speaking women (ages = 19–61) were selected by multi-stage cluster sampling. Data collection tools were Sexual Five Facets Mindfulness Questionnaire (FFMQ-S), short form of marital instability questionnaire (MI) and Sexual Satisfaction Questionnaire (ISS).
Results
Data analysis was performed by SPSS26 and AMOS24 software using descriptive statistics and confirmative factor analysis (Cronbach's alpha, Pearson correlation and construct validity and reliability). The factor structure of FFMQ-S, which has five factors was confirmed. Cronbach's alpha was.89 for the whole questionnaire and for observing, describing, acting with awareness, nonjudging of inner experience, nonreactivity to inner experience were .58, .77, .78, .64 and .80, respectively and the reliability of the construct and five factors was confirmed. Fit indices (GFI = .9, IFI = .9, CFI = .9, CMIN/df = 4.62) were in acceptable range.
Conclusion
The results in the analysis confirmed the reliability of psychometric properties of the FFMQ-S. The FFMQ-S version translated into Persian can be used as a valid tool to measure the mindfulness in sexual interactions and treatment clinics of Iran.