bluuebunny/crossref_metadata_2025_split huggingface dataset:
Variability in surgical treatment of metastatic colorectal cancer (literature review)
Authors: Dobrodeev A. Yu. , Kostromitsky D. N. , Afanasyev S. G. , Tarasova A. S. , Babyshkina N. N. , Ponomareva A. A. 
Published: May 2023

Background. Colorectal cancer (CRC) is one of the most common cancers and one of the most leading causes of cancer-related deaths worldwide. Approximately 35 % of CRC patients have liver metastases at the time of diagnosis. These patients have a poor prognosis, with the 5-year survival rate of 15 %. Given the poor survival with currently approved methods, the development of the optimal treatment options is needed.The purpose of the study was to search for data on the development of surgical techniques for the treatment of patients with metastatic CRC (mCRC) with isolated liver metastasis.Material and Methods. Literature search was carried out in Medline, Cochrane Library, Elibrary and Pubmed databases, including publications characterizing historical and modern results (from 1976 to 2021).Results. Liver resection in mCRC patients with isolated liver metastasis is the only treatment that offers a chance of increasing the 5-year survival rate up to 45–60 %. Radical surgery should include the removal of the primary tumor and all metastases with negative histological resection margins while preserving sufficient functional liver parenchyma. The paper discusses various approaches to surgical treatment of mCRC patients with liver metastases, with an assessment of their advantages and disadvantages, as well as presents data on perioperative and oncological outcomes.Conclusion. The surgical treatment strategy should be adapted for each mCRC patient with synchronous liver metastases. The core function of a multidisciplinary team is to determine the patient’s treatment plan combining surgery and systemic chemotherapy, which will improve the immediate and long-term treatment outcomes.
A rare clinical case of a patient with mixed neuroendocrine-non-neuroendocrine neoplasms of the ampulla of vater
Authors: Drozdov E. S. , Grishchenko M. Yu. , Kharitonkin V. I. , Lyan N. I. , Borodin O. Yu. , Fesik E. A. , Korotkevich A. G. 
Published: May 2023

Background. Neuroendocrine tumors are rare neoplasias accounting for 1 % of all digestive malignancies. In 2010, mixed neuroendocrine-non-neuroendocrine neoplasms (MiNENs) were classified by the World Health Organization This type of tumor is extremely rare and most commonly occurs in the appendix, colon, and rectum. To date, only 30 clinical cases of MINEN of the major duodenal papilla (MDP) have been described in the available world literature, while we have not found a description of this pathology in the domestic literature.Description of the clinical case. We present a case of a 64-year-old male patient with MiNEN MDP. The first clinical manifestation of the disease was obstructive jaundice. To eliminate the jaundice, papillosphincterotomy, transpapillary stenting of the choledochus with a plastic stent was performed. MDP tumor was verifed as adenocarcinoma by histological examination. The patient underwent gastropancreatoduodenal resection. Postoperative immunohistochemical examination showed the expression of antibodies in tumor cells: Synaptophysin (clone 27G12) +++, Chromogranin A (5H7) +, CD 57 (NK-1) ++, Ki 67 (Mib 1) 80 %.Conclusion: mixed neuroendocrine (G3) non-neuroendocrine carcinoma (G2) of the major duodenal papilla with growth within the wall of the duodenum; metastases of the neuroendocrine component in three lymph nodes, adenocarcinoma metastasis in 1 out of 15 lymph nodes examined; pT2N2M0, MiNEN high grade (classified by S. La Rosa). Conclusion. Mixed neuroendocrine-non-neuroendocrine tumors of MDP are an extremely rare pathology. The accuracy of preoperative morphological diagnostics is not high, therefore, this diagnosis can be easily missed at the preoperative stage. In the morphological study of malignant tumors of MDP, a pathologist should take into account the feasibility of a combination of a neuroendocrine tumor with adenocarcinoma.
The effectiveness of a dual-component regimen of induction chemotherapy in the treatment of HPV-positive oropharyngeal squamous cell carcinoma
Authors: Golubev P. V. , Bolotina L. V. , Gevorkov A. R. , Deshkina T. I. , Boyko A. V. , Kaprin A. D. 
Published: May 2023

Given the favorable prognosis associated with HPV-positive oropharyngeal cancer, cancer care professionals are actively discussing the feasibility of de-escalating treatment strategy for this cohort of patients.The purpose of the study was to improve the treatment outcomes in patients with locally advanced HPV- positive oropharyngeal squamous cell carcinoma by identifying the optimal induction chemotherapy (ICH) regimen, in particular, by using a two-drug ICH.Material and Methods. The study included 27 patients with locally advanced (T3–4N0–1, or T1–4N2–3) P16-positive oropharyngeal squamous cell carcinoma. All patients received 3 cycles of ICT according to the TP (docetaxel + cisplatin) regimen. To assess the effect and toxicity of two-drug ICH, a control group of patients, who received ICH according to the standard three-drug TPF (docetaxel, cisplatin and 5FU) regimen, was formed.Results. In the TP group, complete response (CR) was achieved in 3 (11 %) patients, partial response (PR) in 17 (63 %), stable disease (SD) in 7 (26 %) patients. In the control group: CR 4 (20 %) patients, PR – 13 (60 %), SD – 4 (20 %) patients. The median follow-up time in the TP group was 9 months (range: 2 to 22 months). The 1-year progression-free (PFS) and overall survival (OS) rates were 88.2 % and 100 %, respectively. In the TPF group, the PFS and OS rates were 84.4 % and 100 %, respectively.Conclusion. The results revealed that TP ICH regimen was non-inferior to the standard TPF regimen in the rates of the objective response, 1-year OS and PFS.
The role of the study of the level of thyroglobulin in the washout fuid of the needle aspiration for the detection of cervical lymph node metastases in well-differentiated thyroid cancer
Authors: Gogieva E. Kh. , Romanov I. S. , Stanyakina E. E. , Berdnikov S. N. , Pimenova E. L. , Umarova A. I. 
Published: May 2023

The study objective: to assess the diagnostic value of measuring the concentration of thyroglobulin (Tg) in the washout fluid of the fine needle aspiration (FNA) for the detection of well-differentiated thyroid cancer regional metastases.Material and Methods. The study included 64 patients with well-differentiated thyroid cancer. Ultrasound examination revealed 71 enlarged regional lymph nodes. The patients underwent simultaneous FNA cytology examination of lymph nodes and the study of Tg concentration in the washout fluid of the needle aspiration. Regional lymph node metastases were verified in 38 patients. These patients underwent surgery. Histological examination of surgical specimens was performed in 43 out of 71 cases.Results. The sensitivity, specificity, and accuracy of the FNA biopsy and the study of the concentration of thyroglobulin in the in the washout fluid of FNA were 88.5 %, 56.3 %, 76.2 % and 100 %, respectively. The rate of false-positive results of thyroid FNA biopsy was 16 %. The optimal cutoff value for FNA-Tg measurement was 4 g/ml. This made it possible to increase the sensitivity and specificity of the method to 100 %. It was found that the presence of circulating antibodies to Tg in the blood serum had no effect on the diagnostic value of FNA-Tg measurement (p=0.421). There were no statistically significant differences in the levels of thyroglobulin in the in the washout fluid of FNA between patients with Tg concentration above and below the cutoff values (3.9 [0.47; 39.9] ng/ ml vs 12.3 [0.57; 294.8] ng/ml).
Potential of Citrus limetta peel powder (CLPP) for adsorption of hazardous Congo red dye from wastewater
Authors: Aslam Ujala , Javed Tariq 
Published: May 2023

Abstract

In this study, Congo red anionic dye was removed from an aqueous solution using powdered Citrus limetta peel. The adsorbent was evaluated with the use of FTIR and SEM. The highest dye removal was achieved when the operating parameters were optimized, including pH = 6.0, adsorbent dose = 0.4 g, contact time = 90 min, initial adsorbate conc. = 10 ppm, and temperature = 60 °C. The pseudo-second-order model was investigated to have the best fit for the kinetics of the process, with R2 = 0.9918 and Qe(cal) = 0.206 mg g-1, which is very close to the experimental Qe(exp) = 0.191 mg g-1. These two models’ plots showed that both physical and chemical adsorption were feasible. ΔG and ΔH being negative suggest that the adsorption was thermodynamically favorable and spontaneous. Testing the suggested technique with groundwater resulted in an 82% CR adsorption efficiency. Due to the incredible removal capacity of CR dyes from industrial effluents, research suggests that CLPP can be used as substitute adsorbents for the treatment of wastewater from the weaving and dyeing industries.
Mercury and lead pollution in rivers in Ghana: geo-accumulation index, contamination factor, and water quality index
Authors: Anang Emmanuella , Lawson Bernard Walter , Ankrah Aduboffour Victor Kwabena , Tei Meshack , Antwi Anthony Boakye 
Published: May 2023

Abstract

The main environmental problem in Kumasi is water pollution, but little is done about this. Neither water quality nor the degree of heavy metal contamination in Kumasi has been assessed. The degree of mercury and lead pollution in Kumasi was investigated in this study by determining the geo-accumulation index, the contamination factor, and the water quality index (WQI) of mercury and lead in selected rivers in Kumasi. Mercury and lead concentrations were the highest in the Aboabo River, particularly in the Anloga area. This was attributed largely to electronic waste dumping, collection, and processing in the area. The WQI of the rivers indicated that the water was unsuitable for drinking. It is also shown that the water should not be used for crop cultivation or animal rearing, which are among the anthropogenic activities that are both carried out along the rivers, to limit risk to human health.
Investigation into climate change effects on carbon and water fluxes, and water use efficiency of the temperate grassland ecosystems in Inner Mongolia of China
Authors: Wu Zhijun , Li Qiongfang , Xu Shuhong , Chen Qihui , Chen Yunyao 
Published: May 2023

Abstract

The daily gross primary productivity (GPP) and evapotranspiration (ET) in the Xilingol grassland ecosystem of Inner Mongolia were simulated using the BioGeochemical Cycles (Biome-BGC) model for 2003–2019 and under future climate-change scenarios. The system was optimized using the System Response Parameter Calibration Method (SRPCM). The temporal variations of GPP, ET and water use efficiency (WUE) were investigated, and the impacts of precipitation and temperature were explored. Results showed that (i) the BIOME-BGC model performed better when optimized using the SRPCM than by applying the Model-Independent Parameter Estimation approach (PEST); (ii) GPP and ET at annual and seasonal scales showed an insignificant increasing trend; (iii) WUE at the annual scale and in growing seasons showed an insignificant increasing trend and a slight decreasing trend in non-growing seasons; (iv) annual GPP and ET were more sensitive to changes in precipitation than changes in temperature with WUE keeping relatively stable with years; (v) precipitation is a critically controlling factor for GPP and ET in growing seasons and for ET and WUE in non-growing seasons; and (vi) combined temperature and precipitation changes had greater impacts on GPP/ET/WUE than individual changes.
Investigational Agents Targeting SGLT1 and SGLT2 in the Treatment of
Type 2 Diabetes Mellitus
Authors: Cui Haigang , Luo Xin , Chen Mingwei , Lu Jun , Liu Johnson J. 
Published: May 2023

Abstract:
Targeting sodium-dependent glucose transporters (SGLT1 and SGLT2) represents a
new class of pharmacotherapy for type 2 diabetes mellitus, a major global health issue with an increasing
social and economic burden. Following recent successes in market approvals of SGLT2 inhibitors,
the ongoing effort has paved the way for the discovery of novel agents via structure-activity
relationship studies, preclinical and clinical testing, including SGLT2 inhibitors, SGLT1/2 dual
inhibitors, and selective SGLT1 inhibitors. A growing understanding of the physiology of SGLTs
allows drug developers to explore additional cardiovascular and renal protective benefits of these
agents in T2DM patients at risk. This review provides an overview of the recent investigational
compounds and discusses future perspectives of drug discovery in this area.
Mesenchymal Stem Cell-derived Type II Alveolar Epithelial Progenitor Cells
Attenuate LPS-induced Acute Lung Injury and Reduce P63 Expression
Authors: Ma Ning , Zhang Mengwei , Xu Guofeng , Zhang Lifang , Luo Min , Luo Meihua , Wang Xing , Tang Hongmei , Wang Xiaoyun , Liu Li , Zhong Xiaolin , Feng Jianguo , Li Yuying 
Published: May 2023

Aim:
Acute respiratory distress syndrome (ARDS)/acute lung injury (ALI) is a severe clinical
respiratory-failure disease mainly characterized by acute damage to the alveolar epithelium and pulmonary
vascular endothelial cells. Stem cell therapy has emerged as a potential regenerative strategy for
ARDS/ALI, however, the outcome is limited, and the underlying mechanisms are unclear.

Introduction:
We established a differentiation system for bone marrow-derived mesenchymal stem cellderived
(BM-MSC) type II alveolar epithelial progenitor cells (AECIIs) and assessed their regulatory
effects on lipopolysaccharide (LPS)-induced ALI.

Methods:
We induced BM-MSC differentiation into AECIIs using a specific conditioned medium. After
26 days of differentiation, 3×105 BM-MSC-AECIIs were used to treat mice with LPS-induced ALI
through tracheal injection.

Results:
After tracheal injection, BM-MSC-AECIIs migrated to the perialveolar area and reduced LPSinduced
lung inflammation and pathological injury. RNA-seq suggested that P63 protein was involved in
the effects of BM-MSC-AECIIs on lung inflammation.

Conclusion:
Our results suggest that BM-MSC-AECIIs may reduce LPS-induced acute lung injury by
decreasing P63 expression.
Non-small Cell Lung Cancer Survival Estimation Through Multi-omic
Two-layer SVM: A Multi-omics and Multi-Sources Integrative Model
Authors: Manganaro Lorenzo , Sabbatini Gianmarco , Bianco Selene , Bironzo Paolo , Borile Claudio , Colombi Davide , Falco Paolo , Primo Luca , Vattakunnel Shaji , Bussolino Federico , Vittorio Scagliotti Giorgio 
Published: May 2023

Background:
The new paradigm of precision medicine brought an increasing interest in survival
prediction based on the integration of multi-omics and multi-sources data. Several models have
been developed to address this task, but their performances are widely variable depending on the specific
disease and are often poor on noisy datasets, such as in the case of non-small cell lung cancer
(NSCLC).

Objective:
The aim of this work is to introduce a novel computational approach, named multi-omic twolayer
SVM (mtSVM), and to exploit it to get a survival-based risk stratification of NSCLC patients from
an ongoing observational prospective cohort clinical study named PROMOLE.

Methods:
The model implements a model-based integration by means of a two-layer feed-forward network
of FastSurvivalSVMs, and it can be used to get individual survival estimates or survival-based risk
stratification. Despite being designed for NSCLC, its range of applicability can potentially cover the full
spectrum of survival analysis problems where integration of different data sources is needed, independently
of the pathology considered.

Results:
The model is here applied to the case of NSCLC, and compared with other state-of-the-art
methods, proving excellent performance. Notably, the model, trained on data from The Cancer Genome
Atlas (TCGA), has been validated on an independent cohort (from the PROMOLE study), and the results
were consistent. Gene-set enrichment analysis of the risk groups, as well as exome analysis, revealed
well-defined molecular profiles, such as a prognostic mutational gene signature with potential
implications in clinical practice.
p-Coumaric Acid Inhibits Osteosarcoma Growth by Inhibiting PI3K/Akt Signaling
Pathway
Authors: Yang Bo , Wang Bowen , Wang Guoliang , Cao Wenliang , Wang Qian , Pu Hao , An Wei 
Published: May 2023

Background:
Background: P-coumaric acid (p-CA) is a kind of phenylpropionic acid derived from aromatic amino acids,
which is widely distributed in many plants and human diets. It has strong pharmacological and inhibitory effects on a
variety of tumors. However, the role of p-CA in osteosarcoma, a tumor with a poor prognosis, is still unknown. Therefore,
we aimed to evaluate the effect of p-CA on osteosarcoma and explore its potential mechanism.

Objective:
This study aimed to investigate whether p-CA has an inhibitory effect on the growth of osteosarcoma cells
and explore its potential mechanism.

Methods:
Methods: MTT assay and clonogenic assay were used to detect the effect of p-CA on the proliferation of osteosarcoma
cells. The effect of p-CA on apoptosis of osteosarcoma cells was detected by the Hoechst staining and flow cytometry.
The effects of p-CA on the migration and invasion of osteosarcoma cells were detected by scratch healing assay and
Transwell invasion assay. Western blot and PI3K/Akt pathway activator 740Y-P were used to detect the anti-tumor
mechanism of p-CA on osteosarcoma cells. The effect of p-CA on osteosarcoma cells in vivo was verified by an orthotopic
osteosarcoma tumor animal model in nude mice.

Results:
MTT assay and clonogenic assay showed that p-CA inhibited the proliferation of osteosarcoma cells. Hoechst
stain and flow cytometry showed that p-CA could induce apoptosis of osteosarcoma cells and lead to G2 phase arrest
of osteosarcoma cells. Transwell assay and scratch healing assay found that p-CA could inhibit the migration and invasion
of osteosarcoma cells. Western blot showed that p-CA could inhibit the activity of the PI3K/Akt signaling pathway
in osteosarcoma cells, and 740Y-P could reverse its inhibitory effect. In vivo mouse models, p-CA has an antitumor
effect on osteosarcoma cells in vivo, and at the same time, it has less toxic side effects on mice.

Conclusion:
This study demonstrated that p-CA could effectively inhibit the proliferation, migration and invasion of
osteosarcoma cells and promote apoptosis. p-CA may play an anti-osteosarcoma role by inhibiting PI3K/Akt signaling
pathway.
Emerging Nanotechnology for the Treatment of Alzheimer’s Disease
Authors: Singh Aditya , Ansari Vaseem Ahamad , Mahmood Tarique , Ahsan Farogh , Wasim Rufaida , Maheshwari Shubhrat , Shariq Mohammad , Parveen Saba , Shamim Arshiya 
Published: May 2023

Abstract:
Nanotechnology is a great choice for medical research, and the green synthesis approach is
a novel and better way to synthesize nanoparticles. Biological sources are cost-effective, environmentally
friendly, and allow large-scale production of nanoparticles. Naturally obtained 3 β-hydroxy-urs-
12-en-28-oic acids reported for neuroprotective and dendritic structure are reported as solubility enhancers.
Plants are free from toxic substances and act as natural capping agents. In this review, the
pharmacological properties of ursolic acid (UA) and the structural properties of the dendritic structure
are discussed. UA acid appears to have negligible toxicity and immunogenicity, as well as favorable
biodistribution, according to the current study, and the dendritic structure improves drug solubility,
prevents drug degradation, increases circulation time, and potentially targets by using different pathways
with different routes of administration. Nanotechnology is a field in which materials are synthesized
at the nanoscale. Nanotechnology could be the next frontier of humankind's technological advancement.
Richard Feynman first used the term ‘Nanotechnology’ in his lecture, “There is Plenty of
Room at the Bottom”, on 29th December, 1959, and since then, interest has increased in the research
on nanoparticles. Nanotechnology is capable of helping humanity by solving major challenges, particularly
in neurological disorders like Alzheimer's disease (AD), the most prevalent type, which may account
for 60-70% of cases. Other significant forms of dementia include vascular dementia, dementia
with Lewy bodies (abnormal protein aggregates that form inside nerve cells), and a number of illnesses
that exacerbate frontotemporal dementia. Dementia is an acquired loss of cognition in several cognitive
domains that are severe enough to interfere with social or professional functioning. However,
dementia frequently co-occurs with other neuropathologies, typically AD with cerebrovascular dysfunction.
Clinical presentations show that neurodegenerative diseases are often incurable because patients
permanently lose some neurons. A growing body of research suggests that they also advance our
knowledge of the processes that are probably crucial for maintaining the health and functionality of the
brain. Serious neurological impairment and neuronal death are the main features of neurodegenerative
illnesses, which are also extremely crippling ailments. The most prevalent neurodegenerative disorders
cause cognitive impairment and dementia, and as average life expectancy rises globally, their effects
become more noticeable.
Nutrition, Immunity and Aging: Current Scenario and Future
Perspectives in Neurodegenerative Diseases
Authors: Barbero Mazzucca Camilla , Cappellano Giuseppe , Chiocchetti Annalisa 
Published: May 2023

Abstract:
Aging is a gradual decline of physiological function and tissue homeostasis and, in many
instances, is related to increased (neuro)-degeneration, together with inflammation, becoming one of
the most important risks for developing neurodegenerative diseases. Certain individual nutrients or
foods in combination may counteract aging and associated neurodegenerative diseases by promoting a
balance between the pro- and anti-inflammatory responses. Thus, nutrition could represent a powerful
modulator of this fine balance, other than a modifiable risk factor to contrast inflammaging. This narrative
review explores from a broad perspective the impact of nutrition on the hallmarks of aging and
inflammation in Alzheimer’s disease (AD), Parkinson’s disease (PD) and Amyotrophic Lateral Sclerosis
Syndrome (ALS), starting from nutrients up to single foods and complex dietary patterns.