bluuebunny/crossref_metadata_2025_split huggingface dataset:
ORTHOGONAL DECOMPOSITION OF DEFINABLE GROUPS
Authors: BERARDUCCI ALESSANDRO , ELEFTHERIOU PANTELIS E. , MAMINO MARCELLO 
Published: August 2023

AbstractOrthogonality in model theory captures the idea of absence of non-trivial interactions between definable sets. We introduce a somewhat opposite notion of cohesiveness, capturing the idea of interaction among all parts of a given definable set. A cohesive set is indecomposable, in the sense that if it is internal to the product of two orthogonal sets, then it is internal to one of the two. We prove that a definable group in an o-minimal structure is a product of cohesive orthogonal subsets. If the group has dimension one, or it is definably simple, then it is itself cohesive. As an application, we show that an abelian group definable in the disjoint union of finitely many o-minimal structures is a quotient, by a discrete normal subgroup, of a direct product of locally definable groups in the single structures.
Have we lost sleep? A reconsideration of segmented sleep in early modern England
Authors: Boyce Niall 
Published: August 2023

AbstractThe theory that the people of the early modern period slept in well-defined segments of ‘first’ and ‘second’ sleeps has been highly influential in both scholarly literature and mainstream media over the past twenty years. Based on a combination of scientific, anthropological and textual evidence, the segmented sleep theory has been used to illuminate discussions regarding important aspects of early modern nocturnal culture; mainstream media reports, meanwhile, have proposed segmented sleep as a potentially ‘natural’ and healthier alternative to consolidated blocks of sleep. In this article, I re-examine the scientific, anthropological and early modern literary sources behind the segmented sleep theory and ask if the evidence might support other models of early modern sleep that are not characterised by segmentation, while acknowledging that construction of such models is by nature limited and uncertain. I propose a more diverse range of interpretations of early modern texts related to sleep, with important implications for medical and social history and literary scholarship.
Cycles‐L: A Coupled, 3‐D, Land Surface, Hydrologic, and Agroecosystem Landscape Model
Authors: Shi Yuning , Montes Felipe , Kemanian Armen R. 
Published: August 2023

AbstractManaging landscapes to increase agricultural productivity and environmental stewardship can be informed by spatially‐distributed models that operate at spatial and temporal scales that are intervention‐relevant. This paper presents Cycles‐L, a landscape‐scale agroecosystem and hydrologic modeling system, using as a test case a watershed in Pennsylvania. Cycles‐L emerges from melding the landscape and hydrology structure of Flux‐PIHM, a 3‐D land surface hydrologic model, with the agroecosystem processes in the Cycles model. Consequently, Cycles‐L can simulate processes affected by topography, soil heterogeneity, and management practices, owing to its physically‐based hydrology that can simulate horizontal and vertical transport of solutes with water. The model was tested at a 730‐ha experimental watershed within the Mahantango Creek watershed. Cycles‐L simulated well stream water and mineral nitrogen discharge (Nash‐Sutcliffe coefficient 0.55 and 0.60, respectively) and grain yield (root mean square error 1.2 Mg ha−1). Cycles‐L outputs are as good or better than those obtained with the uncoupled Flux‐PIHM (water discharge) and Cycles (grain yield) models. Modeled spatial patterns of nitrogen fluxes like denitrification illustrate the combined control of crop management and topography. For example, denitrification is almost twice as high when simulated with Cycles‐L than when simulated with Cycles 1‐D. Due to its spatial and temporal resolution, Cycles‐L fills a gap in the availability of models that operate at a scale relevant to evaluate interventions in the landscape. Cycles‐L can become a central component in tools for climate change scenario analysis, precision agriculture, precision conservation, and artificial intelligence‐based decision support systems.
Ambient Anthropogenic Carbons and Pediatric Respiratory Infections: A Case‐Crossover Analysis in the Megacity Beijing
Authors: Xu Hongbing , Song Jing , He Xinghou , Guan Xinpeng , Wang Tong , Zhu Yutong , Xu Xin , Li Mengyao , Liu Lingyan , Zhang Bin , Fang Jiakun , Zhao Qian , Song Xiaoming , Xu Baoping , Huang Wei 
Published: August 2023

AbstractCarbon loading in airway cells has shown to worsen function of antimicrobial peptides, permitting increased survival of pathogens in the respiratory tract; however, data on the impacts of carbon particles on childhood acute respiratory infection (ARI) is limited. We assembled daily health data on outpatient visits for ARI (bronchitis, pneumonia, and total upper respiratory infection [TURI]) in children aged 0–14 years between 2015 and 2019 in Beijing, China. Anthropogenic carbons, including black carbon (BC) and its emission sources, and wood smoke particles (delta carbon, ultra‐violet absorbing particulate matter, and brown carbon) were continuously monitored. Using a time‐stratified case‐crossover approach, conditional logistic regression was performed to derive risk estimates for each outcome. A total of 856,899 children were included, and a wide range of daily carbon particle concentrations was observed, with large variations for BC (0.36–20.44) and delta carbon (0.48–57.66 μg/m3). Exposure to these particles were independently associated with ARI, with nearly linear exposure‐response relationships. Interquartile range increases in concentrations of BC and delta carbon over prior 0–8 days, we observed elevation of the odd ratio of bronchitis by 1.201 (95% confidence interval, 1.180, 1.221) and 1.048 (95% CI, 1.039, 1.057), respectively. Stronger association was observed for BC from traffic sources, which increased the odd ratio of bronchitis by 1.298 (95% CI, 1.273, 1.324). Carbon particles were also associated with elevated risks of pneumonia and TURI, and subgroup analyses indicated greater risks among children older than 6 years. Our findings suggested that anthropogenic carbons in metropolitan areas may pose a significant threat to clinical manifestations of respiratory infections in vulnerable populations.
Role of North Atlantic Tripole SST in Mid‐Winter Reversal of NAO
Authors: Tao Lingfeng , Fang Jiabei , Yang Xiu‐Qun , Sun Xuguang , Cai Danping , Wang Yu 
Published: August 2023

AbstractNorth Atlantic Oscillation (NAO) has a significant impact on surrounding winter weather and climate. However, the causes of its occasional reversal between early and late winter remain unclear. This study proposes a mechanism for the mid‐winter reversal of NAO from the perspective of local midlatitude air‐sea interaction. Strong sea surface temperature (SST) tripole events, which are defined by empirical orthogonal function of winter‐mean interannual North Atlantic SST anomalies, are primarily induced by NAO in early winter and peak in January. In late winter, the persistent SST tripole exerts active feedback on atmosphere through diabatic heat and transient eddy forcing. The resulting atmospheric circulation anomalies exhibit an almost reversed NAO pattern in February, which forms a wavetrain originating above the Gulf Stream and propagating to the Middle East and weakens the former SST tripole. Consequently, significant reversals of air temperature anomalies occur in Europe and the Caspian Sea area between February and December.
Modeling the Development of an Equatorial Plasma Bubble During a Midnight Temperature Maximum With SAMI3/WACCM‐X
Authors: Huba J. D. , Liu H.‐L. , McInerney J. 
Published: August 2023

AbstractWe report results from a self‐consistent global simulation model in which a large‐scale equatorial plasma bubble (EPB) forms during a midnight temperature maximum (MTM). The global model comprises the ionospheric code SAMI3 and the atmosphere/thermosphere code WACCM‐X. We consider solar minimum conditions for the month of August. We show that an EPB forms during an MTM in the Pacific sector and is caused by equatorward neutral wind flows. Although this is consistent with the theoretical result that a meridional neutral wind (V) with a negative gradient (∂V/∂θ < 0) is a destabilizing influence [Huba & Krall, 2013, https://doi.org/10.1002/grl.50292] (where a northward meridional neutral wind V is positive and θ is the latitude and increases in the northward direction), we find that the primary cause of the EPB is the large decrease in the Pedersen conductance caused by the equatorward winds.
Striatonigral direct pathway 2-arachidonoylglycerol contributes to ethanol effects on synaptic transmission and behavior
Authors: Augustin Shana M. , Gracias Alexa L. , Luo Guoxiang , Anumola Rishitha C. , Lovinger David M. 
Published: August 2023

AbstractEndocannabinoids (eCB) and cannabinoid receptor 1 (CB1) play important roles in mediating short- and long-term synaptic plasticity in many brain regions involved in learning and memory, as well as the reinforcing effects of misused substances. Ethanol-induced plasticity and neuroadaptations predominantly occur in striatal direct pathway projecting medium spiny neurons (dMSNs). It is hypothesized that alterations in eCB neuromodulation may be involved. Recent work has implicated a role of eCB 2-arachidonoylglycerol (2-AG) in the rewarding effects of ethanol. However, there is insufficient research to answer which cellular subtype is responsible for mediating the 2-AG eCB signal that might be involved in the rewarding properties of ethanol and the mechanisms by which that occurs. To examine the role of dMSN mediated 2-AG signaling in ethanol related synaptic transmission and behaviors, we used conditional knockout mice in which the 2-AG-synthesizing enzyme diacylglycerol lipase α (DGLα) was deleted in dMSNs, DGLαD1-Cre+. Using acute brain slice photometry and a genetically encoded fluorescent eCB sensor, GRABeCB2.0, to assess real-time eCB mediated activity of sensorimotor inputs from primary motor cortices (M1/M2) to the dorsolateral striatum, we showed that DGLαD1-Cre+ mice had blunted evoked eCB-mediated presynaptic eCB signaling compared to littermate controls. Furthermore, ethanol induced eCB inhibition was significantly reduced in DGLαD1-Cre+ deficient mice. Additionally, there was a reduction in the duration of loss of righting reflex (LORR) to a high dose of ethanol in the DGLαD1-Cre+ mice compared to controls. These mice also showed a male-specific decrease in ethanol preference accompanied by an increase in ethanol-induced water consumption in a voluntary drinking paradigm. There were no significant differences observed in sucrose and quinine consumption between the genotypes. These findings reveal a novel role for dMSN mediated 2-AG signaling in modulating ethanol effects on presynaptic function and behavior.
Hexokinase 2 confers radio-resistance in hepatocellular carcinoma by promoting autophagy-dependent degradation of AIMP2
Authors: Zheng Yilin , Zhan Yizhi , Zhang Yuqin , Zhang Yaowei , Liu Yang , Xie Yuwen , Sun Yining , Qian Junying , Ding Yanqing , Ding Yi , Fang Yuan 
Published: August 2023

AbstractWith technological advancements, radiotherapy (RT) has become an effective non-surgical treatment for hepatocellular carcinoma (HCC), comprehensively improving the local control rate of patients with HCC. However, some patients with HCC still experience radio-resistance, cancer recurrence, and distant metastasis following RT. Our previous study has revealed that hexokinase 2 (HK2), a potent oncogene, was overexpressed in radio-resistant HCC cell lines; however, its role in HCC radio-resistance remains elusive. Here, we confirmed the upregulation of HK2 in HCC tissue, which is related to unfavorable prognosis in patients with HCC, and demonstrated that HK2 exerts a radio-resistant role by attenuating apoptosis and promoting proliferation in HCC cell lines. HK2 downregulation combined with ionizing radiation showed an excellent synergistic lethal effect. Mechanistically, HK2 alleviated ionizing radiation-mediated apoptosis by complexing with pro-apoptotic protein aminoacyl tRNA synthetase complex interacting multifunctional protein 2 (AIMP2) while enhancing its autophagic lysosomal-dependent degradation, thereby increasing radio-resistance of HCC. Pharmacologically, ketoconazole, an FDA-approved antifungal drug, served as an inhibitor of HK2 and synergistically enhanced the efficacy of RT. Our results indicated that HK2 played a vital role in radio-resistance and could be a potential therapeutic target for improving RT efficacy in HCC.
Non-flammable solvent-free liquid polymer electrolyte for lithium metal batteries
Authors: Zhu Guo-Rui , Zhang Qin , Liu Qing-Song , Bai Qi-Yao , Quan Yi-Zhou , Gao You , Wu Gang , Wang Yu-Zhong 
Published: August 2023

AbstractAs a replacement for highly flammable and volatile organic liquid electrolyte, solid polymer electrolyte shows attractive practical prospect in high-energy lithium metal batteries. However, unsatisfied interface performance and ionic conductivities are two critical challenges. A common strategy involves introducing organic solvents or plasticizers, but this violates the original intention of security design. Here, an electrolyte concept called liquid polymer electrolyte without any small molecular solvents is proposed for safe and high-performance batteries, based on the design of a room-temperature liquid-state brush-like polymer as the sole solvent of lithium salts. This liquid polymer electrolyte is non-flammable and exhibits high ionic conductivity (1.09 $$\times$$
×
10−4 S cm−1 at 25 °C), significant lithium dendrite suppression, and stable long-term cycling over a wide operating temperature range ( ≥ 1000 cycles at 60 °C and 90 °C). Moreover, the pouch cell can resist thermal abuse, vacuum environment, and mechanical abuse. This electrolyte and design strategy are expected to provide enlightening ideas for the development of safe and high-performance polymer electrolytes.
Neurobiology of osteoarthritis: a systematic review and activation likelihood estimation meta-analysis
Authors: Hall Michelle , Dobson Fiona , Klyne David Murray , Zheng Carmen Jiamin , Lima Yuri Lopes , Egorova-Brumley Natalia 
Published: August 2023

AbstractOsteoarthritis (OA) affects 240 million people worldwide. Neuroimaging has been increasingly used to investigate brain changes in OA, however, there is considerable heterogeneity in reported results. The goal of this systematic review and meta-analysis was to synthesise existing literature and identify consistent brain alterations in OA. Six databases were searched from inception up to June, 2022. Full-texts of original human studies were included if they had: (i) neuroimaging data by site of OA (e.g. hand, knee, hip); (ii) data in healthy controls (HC); (iii) > 10 participants. Activation likelihood estimation (ALE) was conducted using GingerALE software on studies that reported peak activation coordinates and sample size. Our search strategy identified 6250 articles. Twenty-eight studies fulfilled the eligibility criteria, of which 18 were included in the meta-analysis. There were no significant differences in brain structure or function between OA and healthy control contrasts. In exploratory analysis, the right insula was associated with OA vs healthy controls, with less activity, connectivity and brain volume in OA. This region was implicated in both knee and hip OA, with an additional cluster in the medial prefrontal cortex observed only in the contrast between healthy controls and the hip OA subgroup, suggesting a possible distinction between the neural correlates of OA subtypes. Despite the limitations associated with heterogeneity and poor study quality, this synthesis identified neurobiological outcomes associated with OA, providing insight for future research. PROSPERO registration number: CRD42021238735.
Improved methylene blue adsorption from an aqueous medium by ozone-triethylenetetramine modification of sawdust-based biochar
Authors: Hassaan Mohamed A. , Yılmaz Murat , Helal Mohamed , El-Nemr Mohamed. A. , Ragab Safaa , El Nemr Ahmed 
Published: August 2023

AbstractIn this study, sawdust biochar-O3-TETA (SDBT), a novel biochar, was prepared via treatment with 80% sulfuric acid, followed by oxidation by ozone and subsequent treatment with boiling Triethylenetetramine (TETA). Characterization studies of the prepared SDBT adsorbent were performed with SEM–EDX, BET, XRD, BJH, FT-IR, DTA and TGA analyses. The adsorption efficiency of MB dye by SDBT biochar from water was investigated. Methylene Blue (MB) dye absorption was most effective when the solution pH was 12. The maximum removal % of MB dye was 99.75% using 20 mg/L as starting MB dye concentration and 2.0 g/L SDBT dose. The Qm of the SDBT was 568.16 mg/g. Actual results were fitted to Temkin (TIM), Freundlich (FIM), and Langmuir (LIM) isotherm models. The experimental results for SDBT fitted well with all three models. Error function equations were used to test the results obtained from these isotherm models, which showed that the experimental results fit better with TIM and FIM. Kinetic data were investigated, and the pseudo-second-order (PSOM) had R2 > 0.99 and was mainly responsible for guiding the absorption rate. The removal mechanism of the MB dye ions in a base medium (pH 12) may be achieved via physical interaction due to electrostatic interaction between the SDBT surface and the positive charge of the MB dye. The results show that SDBT effectively removes the MB dye from the aqueous environment and can be used continually without losing its absorption efficiency.
Establishment of risk model for elderly CAP at different age stages: a single-center retrospective observational study
Authors: Lv Chunxin , Pan Teng , Shi Wen , Peng Weixiong , Gao Yue , Muhith Abdul , Mu Yang , Xu Jiayi , Deng Jinhai , Wei Wei 
Published: August 2023

AbstractCommunity-acquired pneumonia (CAP) is one of the main reasons of mortality and morbidity in elderly population, causing substantial clinical and economic impacts. However, clinically available score systems have been shown to demonstrate poor prediction of mortality for patients aged over 65. Especially, no existing clinical model can predict morbidity and mortality for CAP patients among different age stages. Here, we aimed to understand the impact of age variable on the establishment of assessment model and explored prognostic factors and new biomarkers in predicting mortality. We retrospectively analyzed elderly patients with CAP in Minhang Hospital, Fudan University. We used univariate and multiple logistic regression analyses to study the prognostic factors of mortality in each age-based subgroup. The prediction accuracy of the prognostic factors was determined by the Receiver Operating Characteristic curves and the area under the curves. Combination models were established using several logistic regressions to save the predicted probabilities. Four factors with independently prognostic significance were shared among all the groups, namely Albumin, BUN, NLR and Pulse, using univariate analysis and multiple logistic regression analysis. Then we built a model with these 4 variables (as ABNP model) to predict the in-hospital mortality in all three groups. The AUC value of the ABNP model were 0.888 (95% CI 0.854–0.917, p < 0.000), 0.912 (95% CI 0.880–0.938, p < 0.000) and 0.872 (95% CI 0.833–0.905, p < 0.000) in group 1, 2 and 3, respectively. We established a predictive model for mortality based on an age variable -specific study of elderly patients with CAP, with higher AUC value than PSI, CURB-65 and qSOFA in predicting mortality in different age groups (66–75/ 76–85/ over 85 years).
Impact of virtual reality exercises on anxiety and depression in hemodialysis
Authors: Turoń-Skrzypińska Agnieszka , Tomska Natalia , Mosiejczuk Hanna , Rył Aleksandra , Szylińska Aleksandra , Marchelek-Myśliwiec Małgorzata , Ciechanowski Kazimierz , Nagay Radosław , Rotter Iwona 
Published: August 2023

AbstractRenal replacement therapy is associated with reduced physical activity. The aim of the study was to assess the relationship between regular physical activity performed with the use of virtual reality and the occurrence of symptoms of anxiety and depression in hemodialysis patients. The study involved 85 patients from the dialysis station at the Department of Nephrology, Transplantology and Internal Medicine PUM. The examined patients were randomly divided into study group and control group. The study group consisted of patients undergoing renal replacement therapy by hemodialysis, whose task was to perform VR exercises using the prototype of the NefroVR system for 20 min during hemodialysis. The control group consisted of patients undergoing renal replacement therapy by hemodialysis who were not assigned an intervention. An intragroup analysis was performed for the Beck and GAD scales. After the end of the exercise cycle in the study group there was a decrease in the score while in the control group there was an increase in comparison to the first result. The research showed that after a 3-month exercises on a bicycle with the use of low-intensity virtual reality, a decrease in depression symptoms measured by the Beck Depression Inventory was observed. The research showed that regular physical activity using virtual reality may be associated with a reduction in the occurrence of anxiety and depression symptoms in patients included in the chronic hemodialysis program.
Depression in healthcare workers during COVID-19 pandemic: results from Czech arm of HEROES Study
Authors: Cermakova Pavla , Fryčová Barbora , Novák David , Kuklová Marie , Wolfová Katrin , Kučera Matěj , Janoušková Miroslava , Pekara Jaroslav , Šeblová Jana , Seblova Dominika 
Published: August 2023

AbstractThe pandemic due to COVID-19 brought new risks for depression of health care workers, which may have differently influenced men and women. We aimed to investigate (1) whether health care workers in Czechia experienced an increase in depression during the COVID-19 pandemic, (2) which factors contributed the most to this change, and (3) whether the magnitude of the associations differed by gender. We studied 2564 participants of the Czech arm of the international COVID-19 HEalth caRe wOrkErS (HEROES) Study. Online questionnaire was administered to health care workers in summer 2020 (wave 0) and spring 2021 (wave 1). Depression was defined by reaching 10 or more points on the Patient Health Questionnaire. Logistic regression investigated the association of participant´s characteristics with depression and multivariable decomposition for non-linear models assessed, to what extent the characteristic explained the change in depression occurrence. The prevalence of depression increased twice during the pandemic (11% in wave 0 and 22% in wave 1). Stress accounted for 50% of the difference, experience of death due to COVID-19 for 15% and contact with COVID-19 patients for 14%. Greater resilience and sufficient personal protective equipment were strongly associated with lower occurrence of depression. The protective association of resilience with depression was stronger in men than in women. We conclude that interventions to promote mental health of health care workers in future health crisis should aim at decreasing stress and enhancing resilience. They should be delivered especially to individuals who have contact with the affected patients and may face their death.