bluuebunny/crossref_metadata_2025_split huggingface dataset:
Open versus robot‐assisted radical cystectomy: pentafecta and trifecta achievement comparison from a randomised controlled trial
Authors: Mastroianni Riccardo , Tuderti Gabriele , Ferriero Mariaconsiglia , Anceschi Umberto , Bove Alfredo Maria , Brassetti Aldo , Misuraca Leonardo , D'Annunzio Simone , Guaglianone Salvatore , Gallucci Michele , Simone Giuseppe 
Published: July 2023

ObjectivesTo compare University of Southern California (USC) Institute of Urology pentafecta and trifecta achievement comparing open radical cystectomy (ORC) vs robot‐assisted RC (RARC) with totally intracorporeal urinary diversion (iUD) from a randomised controlled trial (RCT).Patients and MethodsPatients were eligible for randomisation if they had a diagnostic transurethral resection of bladder tumour with clinical T stage (cT)2–4, cN0, cM0, or recurrent high‐grade non‐muscle‐invasive bladder cancer and no anaesthesia contraindications to robotic surgery. Patients were enrolled with a covariate adaptive randomisation process based on the following variables: body mass index, American Society of Anesthesiologists score, preoperative haemoglobin, planned UD, neoadjuvant chemotherapy, and cT stage. USC pentafecta was defined as the combination at 1 year after surgery of: negative soft tissue surgical margins, ≥16 lymph node (LN) yield, absence of major (Clavien–Dindo Grade ≥III) complications at 90 days, absence of UD‐related long‐term sequalae, and absence of clinical recurrence. Trifecta was defined as the coexistence of daytime urinary continence, absence of major complications and recurrence‐free status, all assessed at 1 year. Continuous and categorical variables were compared using Student's t‐test and chi‐square test, respectively. Univariable logistic regression analysis was performed to assess the role of USC pentafecta and trifecta achievement on health‐related quality of life (HRQoL).ResultsThere was no statistically significant difference in USC pentafecta and trifecta achievement between groups. Among secondary outcomes, univariable logistic regression analysis was performed and both 1‐year USC pentafecta and trifecta achievement were predictors of 2‐year unmodified global HRQoL.ConclusionsThis study supports equivalence of RARC‐iUD and ORC with regard to surgical quality as described by the USC pentafecta and trifecta. We described a significant impact of USC pentafecta and trifecta achievement on global health status/HRQoL, providing a strict correlation between objective evaluation of surgical outcomes and self‐reported HRQoL.
Interfacial rheology and morphology of casein and non‐starch polysaccharides mixed layers at oil/water interface
Authors: Aslan Türker Duygu , Saraç Meryem Göksel , Doğan Mahmut 
Published: July 2023

AbstractThis work aims to determine the importance of the interfacial attributes on the emulsion stability of casein and five different non‐starch polysaccharides (NSPs) and to compare the interfacial rheological properties at the O/W interface. Various interfacial properties of the layers were determined as well as the bulk rheological properties and morphological structures of emulsions. The results of steady interfacial viscosity pointed out that the interfacial film formed by the reaction between casein and lemon fiber had the highest mechanical strength. The molecules of the samples prepared with all other NSPs, except for the emulsions prepared with lemon fiber, were rapidly dispersed and absorbed at the O/W interface, and their Gi′ and Gi″ remained nearly constant throughout the test. As a result, it was found that the layers showed non‐negligible influences on the interfacial behavior, the amount of NSPs adsorbed at the interface, and the viscoelasticity of the interfacial layers.Practical applicationsThis study was conducted considering the interfacial properties of emulsions and evaluated the stability along with the steady and dynamic rheological properties. The obtained results of current study highlighted the importance of determining the interfacial characteristics of non‐starch polysaccharides (NSPs) and casein‐stabilized emulsions because they can be used to predict the stability of emulsion throughout the shelf life and to get a deeper knowledge on the effects of the NSPs fortification on the emulsion efficiency in food products. A strong positive correlation was found between apparent viscosity and the presence of NSPs. Without NSPs, emulsions were unstable due to depletion or bridging aggregation. The findings are of great importance in understanding the stability and behavior of protein and NSPs‐stabilized emulsions. Therefore, the findings of this study will contribute for both the literature and food industry.
Analytical validation of an ELISA for the measurement of feline pancreas‐specific lipase and re‐evaluation of the reference interval and decision threshold for diagnosing pancreatitis
Authors: Wu Yu‐An , Steiner Jörg M. , Huisinga Elke , Beall Melissa J. , Buch Jesse , Fosgate Geoffrey T. , Lidbury Jonathan A. 
Published: July 2023

AbstractBackgroundThe diagnosis of feline pancreatitis can be challenging. The clinical presentation often includes mild, nonspecific clinical signs, such as vomiting, anorexia, and weight loss. Measurement of feline pancreatic lipase immunoreactivity (fPLI) concentration in serum has been reported to be sensitive and specific for a diagnosis of pancreatitis in cats. However, analytical validation for a widely available commercial assay for the measurement of fPLI concentration has not been published.ObjectiveWe aimed to analytically validate the Spec fPL assay (IDEXX Laboratories, Westbrook, ME), a commercial ELISA for the measurement of fPLI concentration, and re‐evaluate its reference interval and decision threshold for diagnosing pancreatitis in cats.MethodsDilutional linearity, accuracy, precision, and the effect of interfering substances were assessed. The upper limit of the reference interval was calculated based on the 95th percentile of results from clinically healthy cats (n = 107), and a decision threshold for diagnosing pancreatitis was calculated with an expected specificity of 99%.ResultsAnalytical validation demonstrated good linearity, accuracy, and precision, as well as the absence of interference from lipemia, hemolysis, or icterus. The upper limit of the reference interval for Spec fPL was determined to be 4.4 μg/L, and the decision threshold (a theoretical cut‐off) for diagnosing pancreatitis was determined to be 8.8 μg/L based on a desired specificity of 99%.ConclusionsThe Spec fPL assay is analytically valid, and results suggest that a decision threshold of 8.8 μg/L would have high diagnostic specificity for excluding clinically healthy cats.
The impact of individualised funding on the wellbeing of mothers raising an autistic child in Aotearoa New Zealand
Authors: Priestley Racheal , Yeung Polly , Cooper Lareen 
Published: July 2023

INTRODUCTION: How best to support the wellbeing of mothers raising autistic children is an emerging issue of importance due to the growth in autism diagnoses. While the move to individualised funding has been seen to promote autonomy for disabled people and their family to make decisions about services to meet their needs, it has also received criticisms, leading to inequitable processes and outcomes. The purpose of this research was to explore how individualised funding has impacted on mothers raising autistic children and their wellbeing.
METHODS: A qualitative approach, combining semi-structured interviews and the theoretical underpinning of social constructionism, was used to interview seven mothers in 2020 to discuss their experiences of raising an autistic children and how individualised funding has impacted on them. Thematic analysis was used to analyse the data collected.
FINDINGS: Key findings indicated that caring for an autistic child has an ongoing negative impact on mothers’ overall wellbeing and the individualised funding did not seem to ease the stresses of caring.
CONCLUSION: Mothers raising an autistic child in Aotearoa New Zealand face complex funding systems, which are difficult to navigate. Individualisation of disability funding frameworks continues to create barriers and negatively impact the wellbeing of mothers. Wellbeing requires the funding support to see the family as a unit of care instead of the individualisation of a child’s needs. Results of this study urge practitioners and policymakers to support parents raising an autistic child in a more flexible and holistic way to meet the unique circumstances of a family.
The challenge of right-wing populism— A human rights approach
Authors: Beddoe Liz 
Published: July 2023

Review of The challenge of right-wing populism—A human rights approach. Edited by Carolyn Noble and Goetz Ottmann (Eds.) Routledge 2021. ISBN 978-0-429-05653-6, pp.235, ebk, NZD78.99.
A Qualitative Investigation of the Psychosocial Impact of Chronic Low Back Pain in Ghana
Authors: Ampiah Josephine Ahenkorah , Moffatt Fiona , Diver Claire , Ampiah Paapa Kwesi 
Published: July 2023

IntroductionChronic low back pain (CLBP) is a global health concern associated with multidimensional/biopsychosocial levels of affectation in developed countries, with holistic management requiring consideration of these factors. There has been minimal research exploring the psychosocial impact of CLBP, and the factors influencing it, in African contexts, with none in Ghana.ObjectivesTo explore the psychosocial impact of CLBP among patients with CLBP in Ghana.DesignQualitative study using individual semistructured face-to-face interviews, underpinned by Straussian grounded theory principles and critical realist philosophy.ParticipantsThirty patients with CLBP attending physiotherapy at two hospitals in Ghana.ResultsFive categories: loss of self and roles, emotional distress, fear, stigmatisation and marginalisation, financial burden, and social support and three mechanisms: acquired biomedical/mechanical beliefs from healthcare professionals (HCPs), sociocultural beliefs and the socioeconomic impact of CLBP were derived.ConclusionCLBP adversely affects multidimensional/biopsychosocial aspects of individuals experiencing CLBP in Ghana. This delineates the need for a biopsychosocial approach to care. There is the need for HCPs in Ghana to reassess current CLBP management strategies to address the influence of adverse HCPs biomedical inclinations on patients’ psychosocial consequences. Population-based education strategies and consideration of formal support systems for persons with disabling CLBP may also be beneficial.
Atomistic modelling and structural characterisation of coated gold nanoparticles for biomedical applications
Authors: Dickers Matthew D. , Verkhovtsev Alexey V. , Mason Nigel J. , Solov’yov Andrey V. 
Published: July 2023

Abstract
This study presents the results of atomistic structural characterisation of 3.7-nm-diameter gold nanoparticles (NP) coated with polymer polyethylene glycol-based ligands of different lengths (containing 2–14 monomers) and solvated in water. The system size and composition are selected in connection to several experimental studies of radiosensitisation mechanisms of gold NPs. The coating structure and water distribution near the NP surface are characterised on the atomistic level by means of molecular dynamics simulations. The results of simulations carried out in this study, combined with the results of our recent study (Verkhovtsev et al. in J Phys Chem A 126:2170–2184, 2022) and those from the field of polymer physics, are used to calculate key structural parameters of the coatings of radiosensitising gold NPs. On this basis, connections between the coating structure and distribution of water are established for different NP sizes as well as lengths and surface densities of coating molecules. The quantitative analysis of water distribution in the vicinity of coated metal NPs can be used to evaluate the radiosensitising effectiveness of a particular NP system based on the proximity of water to the NP metal core, which should impact the production of hydroxyl radicals and reactive oxygen species in the vicinity of metal NPs exposed to ionising radiation.

Graphical abstract
Complications of cyanoacrylate adhesive closure therapy in chronic venous insufficiency: A single center, single-surgeon study
Authors: Keles Ercan 
Published: July 2023

Objectives In this study, we present the complication data of patients we treated for chronic venous insufficiency (CVI) with cyanoacrylate adhesive closure (CAC) therapy for 2 years. Methods Complications of 382 CAC procedures performed by the same surgeon were reviewed retrospectively. Results Independent of patients, depending on the payment system of the state; two hundred twenty-three (58.4%) of 382 procedures were performed using the Venex system, and the Variclose system was used in 159 (41.6%) patients. A phlebitis-like reaction occurred in 46 (12%) patients, induration in 18 (4.7%) patients, hyperpigmentation in five (1.3%) patients, abscesses in four (1%) patients, cellulitis in three (0.8%) patients, and granuloma in one (0.3%) patient. In addition, as serious complications, deep vein thrombosis (DVT) developed in three patients and pulmonary embolism in one of these patients. Interestingly, temporary blindness was also observed in one patient. Conclusions Although CAC therapy is a reliable method, its complications should not be ignored. Its use by experienced surgeons reduces the risk of complications.
Factors influencing the decision-making in laparoscopic partial nephrectomy for small renal masses
Authors: Kazan Ozgur , Cakici Mehmet Caglar , Kokurcan Alihan , Ozenc Gorkem , Karakoyunlu Nihat , Atis Gokhan , Imamoglu Muhammet Abdurrahim , Yildirim Asif 
Published: July 2023

Background and Objectives: We analyzed the factors affecting the decision on surgical approach such as hilum dissection, vessel clamping, and the warm ischemia time (WIT) in laparoscopic partial nephrectomy (LPN) for small renal masses (SRMs). Methods: Patients who underwent LPN for SRMs between 2011 and 2021 in two centers were retrospectively screened. Standardized R.E.N.A.L. nephrometry score (RNS) and each of the components were scored on a Likert scale and the effect on the surgical approach was examined by using them separately. Results: A total of 133 patients, 85 of whom were on-clamp and 48 were off-clamp, were included in the study. Greater tumor size, low BMI, higher RNS, upper pole tumor, low exophytic rate, and nearness to the collecting system were statistically significant for both on/off-clamp and hilar dissection decisions. In multivariate analysis, greater tumor size, upper pole tumor, lower rate of exophytic part (E2), nearness to the collecting system (N3) were independent risk factors for vessel clamping. Greater tumor size and lower exophytic tumor rate (E2) were independent risk factors for hilum dissection. We could not identify any factor affecting WIT. Conclusion: Individual components of RNS may serve as a better tool for decision-making on vessel clamping and hilum dissection during LPN for SRMs.
Interval cancers in a national colorectal screening programme based on faecal immunochemical testing: Implications for faecal haemoglobin concentration threshold and sex inequality
Authors: Clark Gavin RC , Godfrey Thomas , Purdie Calum , Strachan Judith , Carey Francis A , Fraser Callum G , Steele Robert JC 
Published: July 2023

Objective To compare interval cancer proportions (ICP) in the faecal immunochemical test (FIT)-based Scottish Bowel Screening Programme (SBoSP) with the former guaiac faecal occult blood test (gFOBT)-based SBoSP and investigate associations between interval cancer (IC) and faecal haemoglobin concentration (f-Hb) threshold, sex, age, deprivation, site, and stage. Methods The ICP data from first year of the FIT-based SBoSP and the penultimate year of the gFOBT-based SBoSP were compared in a prospective cohort design. Results With FIT, 801 colorectal cancers (CRCs) were screen detected (SDC), 802 were in non-participants, 548 were ICs, 39 were colonoscopy missed and 72 were diagnosed after incomplete screening; with gFOBT: 540, 904, 556, 45, and 13, respectively. FIT had a significantly higher proportion of SDC compared to IC than gFOBT. For FIT and gFOBT, ICP was significantly higher in women than men. As f-Hb threshold increased, ICP increased and, for any f-Hb threshold for men, a lower threshold was required for comparable ICP in women. In Scotland, the current threshold of ≥80 µg Hb/g faeces would have to be lowered to ≥40 µg Hb/g faeces for women to achieve sex equality for ICP. In the FIT-based SBoSP, there were four times as many stage I SDC than IC. This was reversed in advanced stages, with twice as many stage IV CRC diagnosed as IC versus SDC. Conclusions Reducing the numbers of IC requires lowering the f-Hb threshold. Using different f-Hb thresholds for women and men could eliminate the sex disparity, but with additional colonoscopy.
Food-derived Bioactive Peptides with Angiotensin-Converting Enzyme Inhibiting Effect: A Systematic Review
Authors: Daza-Rodríguez Belén , Martínez Angie Rodríguez , Padilla Albeiro Marrugo , Lázaro Johana Márquez 
Published: July 2023

Objective To describe the current scientific evidence of food-derived bioactive peptides and their angiotensin-converting enzyme inhibiting effect. Methods Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) were followed. We searched MEDLINE (through PubMed) and Science Direct databases to identify studies assessing food-derived bioactive peptides and angiotensin-converting enzyme-inhibiting effects. The evidence was organized and presented using tables and narrative synthesis. Results We identified 11 peptides with the best antihypertensive potential: RDGGYCC, LRLESF, FHAPWK, and LVLPG from plants; LSGYGP, ITT, VISDEDGVTH, ATT, and LWHTH from animals; and ALGRV and SPQW from fungi, which demonstrated their antihypertensive potential in vitro and in vivo. Conclusion Overall, food-derived bioactive peptides with hypertensive activity were identified, which shows a promising field as a therapeutic alternative to conventional pharmacological treatments.
Erlotinib-associated interstitial pneumonitis with successful readministration
Authors: Tungjitviboonkun Songphol , Bumrungratanayos Naharuthai , Jitwimungsanon Jedsadakorn 
Published: July 2023

Introduction Erlotinib is the main stay treatment of non-small cell lung cancer (NSCLC) in recent years. Though, interstitial lung disease following erlotinib use is rarely develop, it is a fatal adverse event if not immediately treat. Case Report We report the first case of erlotinib-induced interstitial pneumonitis with successful readministration. A Thai 64-year-old male patient with NSCLC, information includes patient presentation, laboratory findings, chest x-ray, computed tomography (CT) of chest, corticosteroid dose and duration. Management & Outcome The patient readministrated erlotinib after developed interstitial pneumonitis 3 weeks without developing second adverse event. Evaluation of disease after 2 months of treatment is stable disease per RECIST v1.1. Discussion We assumed that the mechanism for interstitial pneumonitis are diverse and some mechanism is not related with drug directly but rather transient condition and the drug can be readministrated without developing second adverse event. This could lead to change in practice of erlotinib readministration in the future.
Implementation and maintenance of an enhanced pulmonary rehabilitation program in a single centre: An implementation study
Authors: van der Braak Kim , Wald Joshua , Tansey Catherine M , Paes Thais , Sedeno Maria , Selzler Anne-Marie , Stickland Michael K , Bourbeau Jean , Janaudis-Ferreira Tania 
Published: July 2023

Background Pulmonary rehabilitation (PR) has major benefits for patients with chronic obstructive pulmonary disease (COPD). An enhanced PR program was developed with a self-management education intervention. The objective of our study was to evaluate the implementation of the enhanced PR program into a single centre. Methods Pre-post implementation study consisted of two evaluation periods: immediately after implementation and 18 months later. Guided by the RE-AIM framework, outcomes included: Reach, Effectiveness, Adoption, Implementation and Maintenance . Results Reach: 70–75% of referred patients agreed to a PR program ( n = 26). Effectiveness: Clinically important improvements occurred in some patients in functional exercise capacity (64% of the patients achieved clinical important difference in 6-min walk test in the first evaluation period and 44% in the second evaluation period), knowledge, functional status, and self-efficacy in both evaluation periods. Adoption: All healthcare professionals (HCPs) involved in PR ( n = 8) participated. Implementation: Fidelity for the group education sessions ranged from 76 to 95% (first evaluation) and from 82 to 88% (second evaluation). Maintenance: The program was sustained over 18 months with minor changes. Patients and HCPs were highly satisfied with the program. Conclusions The enhanced PR program was accepted by patients and HCPs and was implemented and maintained at a single expert center with good implementation fidelity.
Cultural adaptation of the revised Basel Instrument for Rationing of Care to the Turkish context: a study of validity and reliability
Authors: Yürümezoğlu Havva Arslan , Schubert Maria , Sarıoğlu Emine , Kocaman Gülseren 
Published: July 2023

Background: Studies have shown that nurses do not complete one or more necessary nursing care elements in their last shift due to lack of time. The Basel Extent of Rationing Nursing Care (BERNCA) instrument is one of the most used scales to measure the rationing of nursing care. Aim: This study is aimed to culturally adapt the revised BERNCA (BERNCA-R) instrument to the Turkish language and to test its validity and reliability. Methods: A cross-sectional and methodological study was used. The instrument was adapted in three stages: translation and adaptation, content validity testing and validity and reliability. Data were obtained from 350 nurses working in two public acute care hospitals in Turkey, between September 2019 and January 2020. The descriptive statistics, content validity index, exploratory and confirmatory factor analyses, Cronbach’s α, Guttman split-half and inter-item reliability analyses were performed for the analysis of the data. Results: The Turkish version of the BERNCA-R instrument with a 27-item and three-subscales (monitoring, daily care and needs and psychosocial care) structure was found to have acceptable and good fit indices. Conclusion: The Turkish version of the BERNCA-R instrument is valid and reliable tool to measure rationing of nursing care.