bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of body condition score on biochemical parameters and hormonal profiles during the mating period in Ouled Djellal ewes in arid zone
Authors: Titaouine M , Mezerdi F , Makhlouf A , Mohamdi N , Mohamdi H 
Published: January 2023

ABSTRACTThis study aims to evaluate the effect of body condition score (BCS) on hormonal profiles and to reveal their influence on the blood metabolites in Ouled Djellal ewes during the mating period. The experiment was conducted on thirty, clinically healthy and non-pregnant, Ouled Djellal ewes which have been kept into two groups according to their body condition score (Group I: BCS < 2.50 units; n = 13, Group II: BCS > 2.50 units; n = 17). In both groups, oestrus was synchronized using hormonal patterns then the ewes were left to be naturally inseminated. Blood samples were collected at the time of the sponge removal. Plasma concentrations of glucose, triglycerides, cholesterol, total protein, albumin, creatinine, urea, triiodothyronine, thyroxine and Progesterone were recorded. The plasma level of triglycerides and thyroid hormones (T3 and T4) increase significantly (P < 0.01) in group II. Progesterone concentrations were similar (P ≥ 0.05) in both groups at mating period, although we recorded higher rate in group I. Therefore, we conclude that body condition score has a significant impact on some hormone profiles and blood parameters during the mating period.
RegTech Adoption and the Cost of Capital
Authors: Lai Sandy , Lin Chen , Ma Xiaorong 
Published: January 2023

This paper studies the cost of capital effect of a major regulatory technology, or RegTech, event: the staggered implementation of the Electronic Data Gathering, Analysis, and Retrieval (EDGAR) system of the Securities and Exchange Commission in the period from 1993 to 1996. This event represents a largely exogenous shock to corporate information dissemination technologies, resulting in a considerable reduction in information acquisition costs for investors. Using a difference-in-differences research design, we show that the cost of equity capital declines substantially after a firm switches from paper filing to mandatory electronic filing in EDGAR. The effect is stronger for small firms and firms with low analyst coverage and low institutional ownership. We identify three channels through which EDGAR affects a firm’s cost of capital: the liquidity, risk-taking, and corporate governance channels. EDGAR implementation also improves a firm’s investment efficiency significantly. We find evidence that the marginal value of a firm’s capital investment and cash is higher during the post-EDGAR period. This paper was accepted by Suraj Srinivasan, accounting. Funding: C. Lin acknowledges financial support from the National Science Foundation of China [Grant 72192841] and the Research Grants Council of the Hong Kong Special Administration Region, China [Project HKU R7054-18 and T35/710/20R]. S. Lai acknowledges financial support from the Ministry of Science and Technology, Taiwan [Grants 107-2410-H-002-038-MY3 and 110-2410-H-002-079-MY2] and the E. Sun Academic Award. X. Ma acknowledges research support from the University of Macau [Grants SRG2019-00158-FBA and MYRG2020-00259-FBA]. Supplemental Material: Data are available at https://doi.org/10.1287/mnsc.2022.4660 .
CONSUMO DE MEDICAMENTOS DURANTE A PANDEMIA DA COVID-19
Authors: Squinca Mariana , Gonçalves Arcuri Ana Flávia , Raposo Pereira Júlia Thaynara , De Oliveira Ribeiro Thais , Marini Danyelle Cristine 
Published: January 2023

INTRODUÇÃO: O início da pandemia do covid-19 implicou isolamento social, o que dificultou o acesso a serviços de saúde, o que poderia gerar aumento de consumo de medicamentos, por conta própria ou prescrição médica. Ressalta-se também a influência de propagandas popularizando medicamentos sem eficácia comprovada.
OBJETIVO: O presente estudo analisou se ocorreu maior frequência do uso de medicamentos durante o isolamento social, correlacionando o fato com fatores como idade, sexo, classes medicamentosas, aumento da posologia dos fármacos e consumo com ou sem indicação.
3 .MATERIAIS E MÉTODOS: O estudo foi aprovado pelo Comitê de Ética da UNIFAE, CAAE 36933020.7.0000.5382. Trata-se de uma pesquisa transversal realizada através de um questionário no Google Forms, com questões abertas e fechadas. Para verificação de dados foram utilizadas ferramentas de análises estatísticas descritivas.
RESULTADOS: Foram analisadas 566 respostas do questionário, foi constatado que 49,82% dos participantes utilizam medicamentos de uso contínuo, das quais 19,85% necessitaram aumentar dose. Ademais, 57,06 % dos participantes relataram uso de algum outro tipo de medicamento durante a pandemia, sendo estes 74,6 % analgésicos, 48,91% vitaminas, 48,29% antitérmicos, 42,72% anti-inflamatórios, 24,76% antidepressivos e ansiolíticos, 17,95% antibióticos, 16,71% ivermectina, 4,02% nitazoxanida e 1,54% cloroquina.
CONCLUSÕES: Conclui-se, portanto, que as principais classes de medicamentos utilizadas foram os analgésicos, antitérmicos e vitaminas, com aumento na frequência de consumo. Tal utilização emergiu do intuito de reforçar o sistema imunológico, tratar sintomas febris, e tratar queixas relacionadas a dores, mesmo sem prescrição médica.
Service Use Patterns by Children With Down Syndrome in a Canadian Region
Authors: McLennan John D. , Fulford Casey , Hrycko Sophia , Cobigo Virginie , Tahir Munazza 
Published: January 2023

Abstract
Children with Down syndrome require services from different sectors over time to optimize health and development, however, there is little information on longitudinal, cross-sector service use. Parents of children with Down syndrome attending a Canadian children's hospital participated in semistructured interviews covering life-time multiple sector service use. Five key service patterns were identified: (1) primary care physicians playing a circumscribed role; (2) a marked shift in public habilitative service receipt from development agencies in the preschool years to exclusive school delivery after school entry; (3) families obtaining private services to address gaps from public sector services; (4) a prominent role for parents to identify additional services; and (5) service variability as a function of timing and severity of medical comorbidity.
Trend and risk factors of fatal pregnancy termination: A long-term nationwide population-based cross-section survey in Bangladesh
Authors: Das Shathi , Das Jui , Mazumder Kamanasis , Roy Palash , Begum Rehana , Das Sumon Kumar 
Published: January 2023

Background
Pregnant women often experience the fatal outcome of their pregnancy both in developed and impoverished countries. Due to strong health systems and services, factual and historical data are available from developed countries. However, the prevalence trend and risk factors of a fatal termination of pregnancy in developing countries like Bangladesh are still lacking.

Objective
The objective of the current study was to determine the 20 years trend of prevalence and risk factors of fatal pregnancy termination from 1997 to 2018 in Bangladesh.

Method
This study utilised the publicly available seven consecutive cross-data on Bangladesh Demographic and Health Surveys data since 1997 following identical methods among women of reproductive age. Respondent was asked if they had had a fatal pregnancy termination ever. A Generalised Linear model with a log-Poisson link was used to estimate the relative risk of different predictors for four survey time points (1998, 2004, 2011, 2018).

Results
The proportions of fatal pregnancy termination in urban and rural areas were 24% vs. 19% and 24% vs. 22% in 1997 and 2018, respectively. In multivariable analysis, maternal age 30 years and above and obesity were strongly associated in all survey time points. The richest wealth index had a weak association in 1997 but was strongly associated in 2011 and 2018. A significant modest association with secondary complete education level was only observed in 2018.

Conclusion
The overall proportions of fatal pregnancy termination in Bangladesh remain nearly static; however, its risk factors differed across different survey time points.
Efficacy and safety of guide extension catheter in balloon pulmonary angioplasty for treatment of complex lesions in chronic thromboembolic pulmonary hypertension
Authors: Takigami Masao , Nakanishi Naohiko , Tsubata Hideo , Fukai Kuniyoshi , Matsubara Yuki , Yanishi Kenji , Zen Kan , Nakamura Takeshi , Matoba Satoaki 
Published: January 2023

Background
Balloon pulmonary angioplasty (BPA) is used for treatment of inoperable chronic thromboembolic pulmonary hypertension (CTEPH) and residual pulmonary hypertension after pulmonary endarterectomy (PEA) to improve hemodynamics, right ventricular function, and exercise capacity. However, the effectiveness and safety of guide extension catheters for BPA treatment in patients with CTEPH have not been demonstrated.

Methods
We retrospectively analyzed 91 lesions in 55 sessions of 28 patients with CTEPH who underwent BPA using a guide extension catheter. The purpose (backup, coaxial, and extension), efficacy, and safety of the guide extension catheters were explored. The efficacy of the guide extension catheter was assessed based on the success of the procedures and safety was evaluated based on procedure-related complications.

Results
Regarding the intended use, a guide extension catheter was used to strengthen the backup force of the guiding catheter in 52% of cases, extend the tip of the catheter in 38% of cases, and maintain the coaxiality of the guiding catheter in 10% of cases. Procedural success was achieved in 92.7% of 55 sessions and in 95.6% of 91 lesions. Complex lesions had a lower success rate than simple lesions (p = 0.04). Regarding safety concerns, complications were observed in 5 of 55 sessions (9.1%) and 6 of 91 lesions (6.6%). Only one case of pulmonary artery dissection using a guide extension catheter was reported. Except for this one case, extension catheter-related complications were not observed.

Conclusions
A guide extension catheter can be used safely in BPA procedures with anatomically complex pulmonary artery branches and complex lesions by increasing backup support.
The homogeneous causal action principle on a compact domain in momentum space
Authors: Finster Felix , Frankl Michelle , Langer Christoph 
Published: January 2023

Abstract
The homogeneous causal action principle on a compact domain
of momentum space is introduced. The connection to causal fermion systems is worked out.
Existence and compactness results are reviewed. The Euler–Lagrange equations are derived and analyzed
under suitable regularity assumptions.
A twist in sharp Sobolev inequalities with lower order remainder terms
Authors: Hebey Emmanuel 
Published: January 2023

Abstract
Let

(
M
,
g
)

{(M,g)}

be a smooth compact Riemannian manifold of
dimension

n
≥
3

{n\geq 3}

. Let also A be a smooth symmetrical
positive

(
0
,
2
)

{(0,2)}

-tensor field in M. By the Sobolev embedding
theorem, we can write that there exist

K
,
B

>
0

{K,B>0}

such that for
any

u
∈

H
1

⁢

(
M
)

{u\in H^{1}(M)}

,

(0.1)

∥
u
∥

L

2
⋆

2

≤

K
⁢

∥

∇
A

⁡
u

∥

L
2

2

+

B
⁢

∥
u
∥

L
1

2

\|u\|_{L^{2^{\star}}}^{2}\leq K\|\nabla_{A}u\|_{L^{2}}^{2}+B\|u\|_{L^{1}}^{2}

where

H
1

⁢

(
M
)

{H^{1}(M)}

is the standard Sobolev space of functions
in

L
2

{L^{2}}

with one derivative in

L
2

{L^{2}}

,

|

∇
A

⁡
u

|

2

=

A
⁢

(

∇
⁡
u

,

∇
⁡
u

)

{|\nabla_{A}u|^{2}=A(\nabla u,\nabla u)}

and

2
⋆

{2^{\star}}

is the critical Sobolev exponent for

H
1

{H^{1}}

. We compute in this paper the value of the best possible K in (0.1) and investigate the validity of
the corresponding sharp inequality.
Individual risk prediction of high grade prostate cancer based on the combination between total prostate-specific antigen (PSA) and free to total PSA ratio
Authors: Ferraro Simona , Biganzoli Davide , Rossi Roberta Simona , Palmisano Franco , Bussetti Marco , Verzotti Enrica , Gregori Andrea , Bianchi Filippo , Maggioni Marco , Ceriotti Ferruccio , Cereda Cristina , Zuccotti Gianvincenzo , Kavsak Peter , Plebani Mario , Marano Giuseppe , Biganzoli Elia Mario 
Published: January 2023

Abstract

Objectives
Clinical practice guidelines endorse the stratification of prostate cancer (PCa) risk according to individual total prostate-specific antigen (tPSA) values and age to enhance the individual risk-benefit ratio. We defined two nomograms to predict the individual risk of high and low grade PCa by combining the assay of tPSA and %free/tPSA (%f/tPSA) in patients with a pre-biopsy tPSA between 2 and 10 μg/L.

Methods
The study cohort consisted of 662 patients that had fPSA, tPSA, and a biopsy performed (41.3% with a final diagnosis of PCa). Logistic regression including age, tPSA and %f/tPSA was used to model the probability of having high or low grade cancer by defining 3 outcome levels: no PCa, low grade (International Society of Urological Pathology grade, ISUP<3) and high grade PCa (ISUP≥3).

Results
The nomogram identifying patients with: (a) high vs. those with low grade PCa and without the disease showed a good discriminating capability (∼80%), but the calibration showed a risk of underestimation for predictive probabilities >30% (a considerable critical threshold of risk), (b) ISUP<3 vs. those without the disease showed a discriminating capability of 63% and overestimates predictive probabilities >50%. In ISUP 5 a possible loss of PSA immunoreactivity has been observed.

Conclusions
The estimated risk of high or low grade PCa by the nomograms may be of aid in the decision-making process, in particular in the case of critical comorbidities and when the digital rectal examinations are inconclusive. The improved characterization of the risk of ISUP≥3 might enhance the use for magnetic resonance imaging in this setting.
On the membership problem for finite automata over symmetric groups
Authors: Khashaev Arthur A. 
Published: January 2023

Abstract
We consider automata in which transitions are labelled with arbitrary permutations. The language of such an automaton consists of compositions of permutations for all possible admissible computation paths. The membership problem for finite automata over symmetric groups is the following decision problem: does a given permutation belong to the language of a given automaton? We show that this problem is NP-complete. We also propose an efficient algorithm for the case of strongly connected automata.
On the asymptotic normality conditions for the number of repetitions in a stationary random sequence
Authors: Mikhailov Vladimir G. , Mezhennaya Natalia M. , Volgin Artem V. 
Published: January 2023

AbstractWe study conditions of the asymptotic normality of the number of repetitions (pairs of equal values) in a segment of strict sense stationary random sequence of values from {1, 2, …,N} satisfying the strong uniform mixing condition. It is shown that under natural conditions for the number of repetitions to be asymptotically normal as the length of the segment tends to infinity it is necessary for the stationary distribution to be different from the equiprobable one. Under additional conditions the accuracy of the normal approximation in the uniform metrics is estimated.
Groups in which the centralizer of any non-central primary element is maximal
Authors: Shao Changguo , Jiang Qinhui 
Published: January 2023

Abstract
We investigate the structure of finite group G in which the centralizer of each non-central primary element of G is maximal in G.
This provides an answer to the question raised in [X. Zhao, R. Chen and X. Guo, Groups in which the centralizer of any non-central element is maximal,
J. Group Theory 23 2020, 5, 871–878], and also is a generalization of the result in [A. Mann,
Finite groups with maximal normalizers,
Illinois J. Math. 12 1968, 67–75]. In particular, we give an independent criterion of simplicity of a group, asserting that a group G is simple if the centralizer of each non-central primary element is maximal in G.
The Gelfand–Kirillov dimension of Hecke–Kiselman algebras
Authors: Wiertel Magdalena 
Published: January 2023

Abstract
Hecke–Kiselman algebras

A
Θ

{A_{\Theta}}

, over a field

𝕂

{\mathbb{K}}

, associated to finite
oriented graphs Θ are considered. It has been known that every such algebra
is an automaton algebra in the sense of Ufranovskii. In particular, its
Gelfand–Kirillov dimension is an integer if it is finite.
In this paper, a numerical invariant of the graph Θ that determines
the dimension of

A
Θ

{A_{\Theta}}

is found.
Namely, we prove that the Gelfand–Kirillov dimension of

A
Θ

{A_{\Theta}}

is the
sum of the number of cyclic subgraphs of Θ and the number of oriented paths
of a special type in the graph, each counted certain specific number of times.
Multi-coil MRI by analytic continuation
Authors: Webber James W. 
Published: January 2023

Abstract
We present novel reconstruction and stability analysis methodologies for two-dimensional, multi-coil MRI, based on analytic continuation ideas.
We show that the 2-D, limited-data MRI inverse problem, whereby the missing parts of

𝐤

{\mathbf{k}}

-space (Fourier space) are lines parallel to either

k
1

{k_{1}}

or

k
2

{k_{2}}

(i.e., the

𝐤

{\mathbf{k}}

-space axis), can be reduced to a set of 1-D Fredholm type inverse problems. The Fredholm equations are then solved to recover the 2-D image on 1-D line profiles (“slice-by-slice” imaging). The technique is tested on a range of medical in vivo images (e.g., brain, spine, cardiac), and phantom data.
Our method is shown to offer optimal performance, in terms of structural similarity, when compared against similar methods from the literature, and when the

𝐤

{\mathbf{k}}

-space data is sub-sampled at random so as to simulate motion corruption. In addition, we present a Singular Value Decomposition (SVD) and stability analysis of the Fredholm operators, and compare the stability properties of different

𝐤

{\mathbf{k}}

-space sub-sampling schemes (e.g., random vs uniform accelerated sampling).
Design and performance analysis of optical sequence detector using lithium niobate-based Mach–Zehnder interferometers
Authors: Subbanna Bangi Bala , Choudhary Kuldeep , Singh Sonika , Kumar Santosh 
Published: January 2023

Abstract
Present article suggested and proposed a new design of 4-bit optical sequence detector using an electro-optic effect by utilizing Lithium niobate (LiNbO3) based Mach–Zehnder interferometer, because of its consistency about production and stability. Suggested sequential detector is designed by OptiBPM (optical beam propagation method) software. This structure uses EO effect to alter the light upon lithium niobate optical waveguide via cross-state to bar-state and replica. Sequence detector is a sequential state machine, that extract an input string of bits and, when the targeted bit has been detected, then it gives an output as 1. In this paper the authors have focused on all-optical 4-bit sequential detector to produce the outcome as 1 when the bit sequence finds as 1101 within the given data. This all-optical device can be utilized in several optical switching and networking operations. The suggested design is replicated with MATLAB along with mathematical descriptions too and has been verified.
Factors in sound change: A quantitative analysis of palatalization in Northern Mandarin
Authors: Liu Sha 
Published: January 2023

AbstractFactors in sound change are still a major subject of debate in the field of linguistics, with the frequency factor perhaps being the most controversial. The present article focuses on palatalization of the velars before high front vowels and glides in Northern Mandarin, because palatalization stretched for more than 100 years and can provide detailed information concerning its contour. Based on a statistical analysis of corpus data of palatalization in Northern Mandarin, the present article argues that the factor of frequency is positively associated with palatalization and the factor of frequency change is negatively associated. Morphosyntactic structure and word class are also claimed to be factors in sound change. However, neither of these two factors has emerged as significant in the current study.
Effect of polypyrrole surface modification on antifouling performance of PTFE microfiltration membrane
Authors: Li Jiazhu , Liu Yanqing , Qu Liwei , Cao Xian , Li Xianning 
Published: January 2023

Abstract
In this study, polypyrrole was prepared by in situ chemical oxidation polymerization and deposited on the surface of the PTFE membrane. The surface morphology of the membrane shown that the membrane fouling degree of the modified membrane was much lower than that of the original membrane. Besides, the contact angle value decreased from 107.20° to 72.62°, and its hydrophilicity was significantly enhanced. It took humic acid (HA) as a typical representative membrane foulants, and static and dynamic HA adsorption experiments were carried out on the membranes before and after modification. In the static adsorption experiment of HA, the adsorption capacity of an original membrane was 1.28 times that of a modified membrane. In the dynamic antifouling experiment of HA, the rejection of the modified membrane to HA was 62.99%, while that of the original membrane was only 39.82%. In addition, the experimental results showed that the modified membrane had a higher flux recovery rate, which was 1.18 times that of the original membrane. This study proves that the modified membrane has an extraordinary antifouling effect.
MitoStores: chaperone‐controlled protein granules store mitochondrial precursors in the cytosol
Authors: Krämer Lena , Dalheimer Niko , Räschle Markus , Storchová Zuzana , Pielage Jan , Boos Felix , Herrmann Johannes M 
Published: January 2023

AbstractHundreds of nucleus‐encoded mitochondrial precursor proteins are synthesized in the cytosol and imported into mitochondria in a post‐translational manner. However, the early processes associated with mitochondrial protein targeting remain poorly understood. Here, we show that in Saccharomyces cerevisiae, the cytosol has the capacity to transiently store mitochondrial matrix‐destined precursors in dedicated deposits that we termed MitoStores. Competitive inhibition of mitochondrial protein import via clogging of import sites greatly enhances the formation of MitoStores, but they also form during physiological cell growth on nonfermentable carbon sources. MitoStores are enriched for a specific subset of nucleus‐encoded mitochondrial proteins, in particular those containing N‐terminal mitochondrial targeting sequences. Our results suggest that MitoStore formation suppresses the toxic potential of aberrantly accumulating mitochondrial precursor proteins and is controlled by the heat shock proteins Hsp42 and Hsp104. Thus, the cytosolic protein quality control system plays an active role during the early stages of mitochondrial protein targeting through the coordinated and localized sequestration of mitochondrial precursor proteins.