bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of testosterone, estradiol and progesterone immunoassay calibrators by liquid chromatography mass spectrometry
Authors: Handelsman David J. , Jones Graham , Kouzios Dorothy , Desai Reena 
Published: June 2023

Abstract

Objectives
In clinical practice, steroid measurements are performed mainly by direct, non-extraction immunoassays adapted to high throughput, automated immunoassay platforms and employing secondary calibrators. The accuracy of such steroid immunoassays is limited by cross-reactivity with structurally related steroids and nonspecific matrix interference as well as the metrological traceability of manufacturer supplied calibrators. The accuracy of steroid immunoassay calibrators has been little investigated by independent chemical methods.

Methods
Steroid concentrations of 41 calibrators (4–6 replicates per calibrator) supplied by four manufacturers for use in testosterone (T), estradiol (E2), and progesterone (P4) commercial immunoassays were measured by ultra-pressure liquid chromatography-mass spectrometry (UPLC-MS).

Results
Among 14 non-zero T calibrators, six (43 %) deviated significantly from the label concentration with 29 % outside 20 % of it. Among 14 E2 calibrators, eight (57 %) deviated significantly, whereas seven (50 %) were outside 20 % of the label concentration. Among 11 P4 calibrators, eight (73 %) deviated significantly whereas four (36 %) were outside within 20 % of the label concentration.

Conclusions
We conclude that inaccurate calibration of manufacturer’s supplied standards may contribute to inaccuracy of commercial direct steroid immunoassays.
An improved Kloubuchar ionospheric correction model for single frequency GNSS receivers
Authors: Devanaboyina Venkata Ratnam 
Published: June 2023

Abstract
The enhancement of positional accuracy of single frequency ionospheric correction models is an urgent need for low-cost and smartphone GNSS users. The available single frequency ionospheric correction models such as Klobuchar, NeQuick-G, NTCM, and Klob-BDS are providing ionospheric corrections for multi GNSS systems such as GPS, Galileo, BDS, and NAVIC systems. Otherwise, Global Ionospheric Map (GIM) Total Electron Content (TEC) corrections are also available to the GNSS users. In this letter, an improved Klobuchar ionospheric model is implemented. The slant TEC of dual Frequency GPS TEC observations is considered a reference. The Klobuchar model slant TEC observations are improved by taking the grid-based residual TEC corrections with the Adjusted Spherical Harmonic Function model. The Single frequency users can improve the ionospheric delay estimation using Klobuchar model and grid-based TEC residual corrections. The improved ionospheric correction model is tested under the biggest geomagnetic storm conditions during 24th Solar cycle that occurred in March 2015 over India. The proposed hybrid slant ionospheric TEC algorithms are evaluated with individual single frequency ionospheric models (Klobuchar, and GPS TEC) under adverse space weather conditions.
Unveiling and validation of a disulfidptosis determined prognostic model for osteosarcoma: new insights from prognosis to immunotherapy and chemotherapy
Authors: Zou Jiahao , Chen Liang , Xu Hao 
Published: June 2023

Abstract

Objectives
Disulfidptosis, a novel form of cell death, has been reported to the be result of high levels of SLC7A11 protein after glucose starvation that led to cell death. In this study, we aimed to illustrate the association between disulfidptosis and osteosarcoma.

Methods
Patients were collected from TARGET-OS and GSE21257, with a sequence matrix and clinical features. A total of 77 disulfidptosis genes were collected from the literature. A disulfidptosis-related prognostic signature (DSPR) was constructed using univariate Cox analysis, LASSO regression, and risk score computation. Nomograms were established by integrating independent prognostic factors and DSPR signatures. The Student’ t-test or Mann-Whitney U test was used to compare between the two groups. The Log-rank test, univariate and multivariate Cox regression was performed for survival analysis.

Results
A total of three distinct subtypes (C1, C2, and C3) with varying overall survival prognoses were identified. Comparison between C1 and C3 subtypes revealed 56 differentially-expressed genes, with six genes linked to prognosis. Using LASSO regression, a DSPR signature was constructed, which served as an independent prognostic indicator [hazard ratio (HR)=4.370, 95 % confidence interval (CI): 1.837–10.388, p<0.001], and further validated in an external GSE21257 cohort (HR=4.000, 95 % CI: 1.517–10.183, p=0.004). Nomogram incorporating clinical factors and DSPR signatures showed high predictive accuracy, with AUC values of 0.952 at 1-year, 0.890 at 2-year, and 0.873 at 3-year follow-up. Personalized therapy prediction indicated that low-point patients benefited more from anti-PD-1 immunotherapy, while for high-point patients, chemotherapy was a better treatment option.

Conclusions
In this study, we identified disulfidptosis-associated genes and unraveled their roles in osteosarcoma prognosis, constructed a prognostic signature, and provided guidance for personalized treatment strategies.
Incomplete fusion reaction producing Pa nuclides in the 232Th + 7Li reaction
Authors: Teranishi Kakeru , Morita Ryoga , Hayakawa Yuta , Sakaguchi Aya , Nakajima Akihisa , Komori Yukiko , Yokokita Takuya , Mori Daiki , Haba Hiromitsu , Yokoyama Akihiko 
Published: June 2023

Abstract
The 237Np (t
1/2 = 2.1 × 106 y) nuclide is produced in nuclear facilities. Its investigation is relevant to earth sciences as concerns environmental pollution and material circulation. We expected that this nuclide should be able to be analyzed by mass spectrometry with a neptunium tracer as a spike, such as that of 236gNp (t
1/2 = 1.5 × 105 y). Our research group has collected fundamental data for cross-sections of the 232Th + 7Li reaction for use in spike production. In addition to the complete fusion reaction, incomplete fusion also occurs, especially in the reaction of 7Li, which splits into α and t, and only a part of the projectile fuses with the target nucleus. In this study, the excitation functions of Pa isotopes, as products of the incomplete fusion reaction, were measured. The reaction mechanism is discussed by comparing the experimental values with those calculated using the EMPIRE code. In addition, we investigated the effect of incomplete fusion reaction on the entire reaction.
66th International Open Readings Conference for students of Physics and Natural Sciences. Annual Abstract Book 2023
Authors: Keršys Martynas , Mickus Šarūnas 
Published: June 2023

“Open Readings 2023” – is an international academic platform for students and young researchers from all over the world to present their ongoing research results and practices in the fields of physics and natural sciences.
The 66th International Scientific Conference for Students of Physics and Natural Sciences gathers people to discuss, learn, exchange and share their scientific experience, meet key experts and enjoy an exciting programme. The conference includes lectures of well-known, leading and accomplished scientists and presentations of students’ research. “Open Readings 2023” gives an opportunity for BSc, MSc and PhD students, who are doing their scientific research, to present it to a larger audience, and get constructive criticism and helpful advice. This book gives an overview of all Open Readings 2023 conference presentations.
Properties of self-compacting concrete modified with m-sand and spent foundry slag
Authors: Udayasree B. , Kumar G. Shravan 
Published: June 2023

AbstractDue to significant industrialization, many countries have adopted the practice of industrial symbiosis, which involves utilizing the waste produced by one industry as a resource for another industry. The utilization of spent foundry sand (SFS), which is derived from the metal casting industry, poses a significant risk to both the environment and living organisms as a result of the existence of inorganic and organic substances. Nevertheless, this waste material can serve as a valuable resource for the construction sector. The utilization of SFS is significantly restricted due to insufficient comprehension of its concrete performance, despite its extensive range of applications. It is imperative to comprehend the behavior of spent foundry sand in concrete, particularly in relation to achieving a structure that is both strength-efficient and durable. The current study explores the usability of M-sand and spent foundry sand in self-compacting concrete. Reference concrete was produced by replacing river sand with 100% M-sand. M-sand was substituted with spent foundry sand in ratios ranging from 0 to 30%. Compared to the reference mix, SCC's mechanical and durability properties with 20% SFS were better. In comparison to the reference mix, SCC containing 20% SFS had higher mechanical and durability characteristics at 3, 7, 28 days, and 28 days, respectively. With 20% SFS, replacement showed better mechanical properties at all curing ages and better durability performance at 28 days of the curing period.
RILEM TC 277-LHS report: additives and admixtures for modern lime-based mortars
Authors: Maravelaki Pagona-Noni , Kapetanaki Kali , Papayianni Ioanna , Ioannou Ioannis , Faria Paulina , Alvarez Jose , Stefanidou Maria , Nunes Cristiana , Theodoridou Magdalini , Ferrara Liberato , Toniolo Lucia 
Published: June 2023

AbstractThe scope of this collective paper produced in the frame of RILEM TC 277-LHS is to provide sound knowledge on the use of additives/admixtures in lime-based mortars, based on literature and practice. The most widely known additives/admixtures are systematically presented. Their main effects and testing of their performance have been properly tabulated. It is well known that a plethora of additives/admixtures are produced every year by chemical industries. However, when using them in lime-based mortars, compatibility and durability aspects are of primary importance. The introduction of additives/admixtures in lime mortars was imposed by the need to improve important properties of these composites in the fresh and hardened state, namely, workability, durability, early-age and long-term strength and to reduce defects, such as shrinkage and long setting time. In this review paper, the terminology proposed by EN 16572 is followed, designating additive as a constituent added in small quantity to the binder, and admixture as a substance in quantities at least 1% w/w added to the mix. The additives/admixtures are classified according to their action and their validation with specific testing methodologies highlights the dosage sensitivity and the need to develop further standardization. The combination of different additives proposed in several studies resulted as the most promising strategy to enhance the performance of lime mortars. However, recently developed additives and admixtures need to be further evaluated with reference to their compatibility with other mortar constituents, and their effects on the overall mortar and render durability need to be studied. Finally, adopting similar terminology for additives/admixtures in lime and cement-based mortars will facilitate better comparison and assessment issues.
Analisis Faktor-Faktor Yang Mempengaruhi Permintaan Kurma Kemasan Merek Humaira Anggur di Kota Banda Aceh
Authors: Makmur T , Fauzi T , Yuspita Rana 
Published: June 2023

Permintaan adalah jumlah barang dan jasa yang akan dibeli konsumen pada periode waktu dan keadaan tertentu.Penelitian ini bertujuan untuk menganalisis trend permintaan kurma kemasan merek Humaira Anggur di Kota Banda Acehdan untuk menganalisis faktor-faktor yang mempengaruhi permintaan kurma kemasan merek Humaira Anggur di Kota Banda Aceh. Penentuan lokasi penelitian dilakukan secara purposive, pengambilan sampel penelitian ini dilakukan secaraaccidental, dengan jumlah sampel sebanyak 35.Data yang digunakan adalah data primer dari konsumen di 7 lokasi penelitian melalui wawancara langsung dengan menggunakan kuesioner dan data sekunder dari PT. Humaira Trading. Penelitian ini menggunakan analisis trend dananalisis regresi linear berganda. Hasil analisis trend menunjukkan trend positif, dengan peningkatan sebesar 1,9 ton per tahun dan faktor-faktor yang mempengaruhi permintaan kurma kemasan Humaira Anggur secara signifikan adalah pendapatan konsumen, puasa sunnah, dan bulan ramadhan, sedangkan variabel yang tidak berpengaruh adalah harga buah kurma kemasan Humaira Anggur, harga buah kurma curah, dan gaya hidup.Demand is the amount of goods and services consumers will buy in a certain period of time and circumstances. The aims of this study is to analyze the demand trend of Humaira Anggur dates in Banda Aceh and to analyze the factors that affect the demand of Humaira Anggur dates in Banda Aceh. The location of this research is determined by using purposive method, while the sample of thestudy, 35 samples,taken by utilizing accidental method. The primary data are collected from consumers in 7 stores in Banda Aceh, through direct interview by using questioner and the secondary data are obtained from PT. Humaira Trading’s report. The data are analyzed by using trend analysis method and multiple linear regression. The result of trend analysis shows positive trend, with an increase of production around 1.9 tons/year. The linear regression indicates that the factors that significantly influence the demand of Humaira Anggur dates are consumer income, fasting sunnah, and month of ramadhan, whereas the price of the Humaira Anggur dates, price of other dates, and lifestyle in significantly.
STRATEGI PENGEMBANGAN BUBUK KOPI GAYO DI KABUPATEN ACEH TENGAH
Authors: Bagio Bagio , Kembaren Emmia Tambarta , Fadli Fadli , Suryadi Suryadi 
Published: June 2023

Potensi luas lahan dan kegiatan pengolahan kopi memang menjadi landasan ekonomi masyarakat, namun belum memiliki dampak langsung terhadap proses pengembangan produk inovatif kopi, sedangkan produk kopi arabika Gayo yang dipasarkan saat ini masih didominasi dalam bentuk green bean saja. Penelitian berlokasi di Kabupaten Aceh Tengah dengan pertimbangan besarnya potensi pengembangan produk olahan kopi Gayo. Pengumpulan data dilakukan dengan teknik FGD (Focus Group Discussion) untuk menghasilkan faktor kekuatan dan kelemahan, serta peluang dan ancaman sebagai dasar penyusunan strategi pengembangan produk bubuk kopi Gayo. Rumusan strategi pengembangan produk bubuk kopi Gayo dari matriks SWOT adalah a) Mengembangkan wilayah sentra produksi kopi Gayo di Aceh Tengah yang didasari indeks geografis dengan sistem tanam varietas sejenis dengan karakteristik rasa yang beragam serta mempromosikan kopi arabika Gayo melalui event seperti pameran, b) Pengusaha industri bubuk kopi nasional perlu didukung sistem permodalan dan riset untk upaya diversifikasi dan pengembangan inovasi produk olahan, c) Pengembangan inovasi varian rasa bubuk kopi Gayo sesuai selera konsumen, d) Mengurangi intensi persingan di antara daerah penghasil kopi, perlu dilakukan segmentasi pasar bubuk kopi berdasarkan negara tujuan dan target pelanggan, perlu standardisasi proses sertifikasi sistem industri kopi arabika berdasarkan selera negara tujuan.Kata kunci: Kopi Bubuk Gayo, Strategi Pengembangan
ANALISIS PENGUKURAN TINGKAT MINAT TEKNOLOGI SMART FARMING PADA PETANI KOMODITI PADI DI KABUPATEN ACEH UTARA
Authors: Farabi Achmad Ziyan , Rahmaddiansyah Rahmaddiansyah , Sofyan Sofyan 
Published: June 2023

Sektor pertanian telah memainkan peran penting sepanjang sejarah manusia hingga sekarang, dikarenakan pertanian sangat penting bagi kelangsungan hidup manusia. Saat ini kita sedang mengalami perubahan yang sangat baru di bidang pertanian yang disebut dengan smart farming. diterapkan sebagai inovasi di bagian input, proses, dan output. Ini juga melibatkan peningkatan metode dan alat yang mendorong pembangunan pertanian. Minat merupakan momen dan kecenderungan yang searah secara intensif kepada suatu objek yang dianggap penting. Penelitian ini merupakan penelitian awal untuk mengidentifikasi jenis teknologi smart farming yang diminati oleh petani komoditi padi di Kabupaten Aceh Utara. Di Provinsi Aceh, petani belum banyak yang memanfaatkan SFT dalam usahatani. Dikarenakan mayoritas petani di provinsi aceh masih kurang akan informasi mengenai pentingnya smart farming. Maka dari itu, perlu adanya tingkat minat pengunaan jenis teknologi smart farming dalam usahatani untuk mengetahui jenis-jenis SFT yang beredar di dunia dan dibutuhkan. Penelitian ini menggunakan analisis uji tabulasi silang (cross tabulation). Hasil penelitian yang dilakukan yaitu hasil uji crosstabs menunjukkan petani komoditi padi paling meminati jenis SFT yaitu Autonomous machines dengan jumlah 51 petani, FMIS/Apps berminat sejumlah 49 petani, Recording/mapping berjumlah 47 petani dan Tractor GPS/Connected tools diminati berjumlah 40 petani.
Dual Design PID Controller for Robotic Manipulator Application
Authors: Chotikunnan Phichitphon , Chotikunnan Rawiphon 
Published: June 2023

This research introduces a dual design proportional–integral–derivative (PID) controller architecture process that aims to improve system performance by reducing overshoot and conserving electrical energy. The dual design PID controller uses real-time error and one-time step delay to adjust the confidence weights of the controller, leading to improved performance in reducing overshoot and saving electrical energy. To evaluate the effectiveness of the dual design PID controller, experiments were conducted to compare it with the PID controller using least overshoot tuning by Chien–Hrones–Reswick (CHR) technique. The results showed that the dual design PID controller was more effective at reducing overshoot and saving electrical energy. A case study was also conducted as part of this research, and it demonstrated that the system performed better when using the dual design PID controller. Overshoot and electrical energy consumption are common issues in systems that can impact performance, and the dual design PID controller architecture process provides a solution to these issues by reducing overshoot and saving electrical energy. The dual design PID controller offers a new technique for addressing these issues and improving system performance. In summary, this research presents a new technique for addressing overshoot and electrical energy consumption in systems through the use of a dual design PID controller. The dual design PID controller architecture process was found to be an effective solution for reducing overshoot and saving electrical energy in systems, as demonstrated by the experiments and case study conducted as part of this research. The dual design PID controller presents a promising solution for improving system performance by addressing the issues of overshoot and electrical energy consumption.
Comparison of efficacy of low-dose norepinephrine infusion with low-dose boluses of norepinephrine in managing hypotension among parturients undergoing caesarean section under the subarachnoid block
Authors: Shrieaswari S , Sujatha M P 
Published: June 2023

: Spinal anesthesia is increasingly popular over general anesthesia due to several advantages. Hypotension can complicate spinal anesthesia during a cesarean section, which could have negative repercussions on the mother and fetus. This study is aimed to compare the efficacy of low-dose norepinephrine infusion with low-dose boluses of norepinephrine in managing hypotension among parturients undergoing cesarean section under subarachnoid block.: Ninety-nine parturients without comorbidities who underwent caesarean section with spinal anesthesia received norepinephrine were considered. They were divided into three groups. Group A- Parturient received a norepinephrine infusion of 1 mcg/min and a rescue bolus of 3 mcg to treat hypotension. Group B- Parturient received a Norepinephrine bolus of 3mcg to treat hypotension. Group C- Parturient received a Norepinephrine bolus of 5 mcg to treat hypotension. All the vitals at different intervals, number of norepinephrine boluses, the total amount of norepinephrine consumed, maximum sensory level achieved, time for baby extraction following subarachnoid block, and any adverse events were documented.No statistical difference was noted in the study group's demographics. However, there was a significant difference in mean systolic blood pressure between the groups from skin incision to baby extraction at T6 and T8. In addition, the mean arterial blood pressure of the two groups differed significantly throughout the period from baby extraction to skin suturing. Between the groups, there was a substantial difference in the total number of boluses needed. The total number of boluses required was maximum in group B, followed by group C. Group A required the minimum number of total norepinephrine boluses.A prophylactic norepinephrine infusion is an effective and straightforward method of reducing the incidence and magnitude of hypotension following spinal anesthesia for cesarean section with no adverse effect.
A prospective randomized trial of evaluation of post-operative analgesia of erector spinae plane block in patients undergoing laparotomy
Authors: Raikwar Madhavi A , Cham Soma C , Atkari Rashmi S , Marathe Akshay P , Nayar Shweta S , Sangawar Medha A , Cham Chandrashekhar 
Published: June 2023

The erector spinae plane block (ESPB) can be used to reduce pain and opioid requirements after abdominal surgery.The study was undertaken to assess post-operative analgesia of ESPB in patients undergoing laparotomy under general anaesthesia. A total 34 patients of either sex, age between 20-60 years, ASA status 1 and 2 undergoing exploratory laparotomy were included and equally randomised into two study groups of 17 each. Group A received ESPB with 0.25% inj. bupivacaine 20ml on each side (Total 40ml 0.25% inj. Bupivacaine) and group B with no intervention. The mean VAS Score was &#60;4cm till 1½hr in both the groups. Henceforth, mean VAS sores were observed to be &#60;1cm in all the patients of Group A till 24hr whereas VAS Scores were &#62;4cm all intervals till 24hr in Group B. Thus, quality of analgesia was better in Group A. In Group B, 10 (58.82%) out of 17 patients required first dose of tramadol at 1½ hr as compared to none in Group A. At 24hr, all patients in Group B received tramadol as rescue analgesic compared to only 3 (17.64%) in Group A. The cumulative tramadol consumption was significantly low in Group A (5.88±13.71mg) than Group B (191.76±40.65mg). Complications like nausea, vomiting was more in Group B because of increased tramadol consumption.ESPB is a simple, easy, convenient option, when utilized as a component of multi-modal analgesia for pain relief in abdominal surgery.
The inculcation of entrepreneurial characteristics in high school students through historical figures
Authors: Suharya Toto , Supriatna Nana , Yulifar Leli , Supriatna Encep 
Published: June 2023

The study of historical figures in high school has tended to focus excessively on providing facts rather than lessons about real-life experiences and character values. Entrepreneurs are a valuable resource in the twenty-first century. It takes a history-learning strategy to teach the entrepreneurial character of historical figures. This study aims at improving students' understanding and attitudes toward the entrepreneurial character of historical figures. In addition, this study employs an action research design involving 27 high school students. The results showed that students' understanding and positive attitudes towards the four stories and the value of the entrepreneurial character of the figures could be improved. Six learning actions are effective steps to inculcate an understanding of the four stories and the values of entrepreneurial character from the figures. The study's findings can be used to apply entrepreneurial character education and provide learning materials for successful entrepreneurs throughout historical learning.
Keywords: Action research; entrepreneurial characters; four stories; historical figures.