bluuebunny/crossref_metadata_2025_split huggingface dataset:
Okra ameliorates hyperglycaemia in pre-diabetic and type 2 diabetic patients: A systematic review and meta-analysis of the clinical evidence
Authors: Mokgalaboni Kabelo , Lebelo Sogolo Lucky , Modjadji Perpetua , Ghaffary Saba 
Published: April 2023

Background: Despite the use of available pharmaceutical drugs, high rates of metabolic diseases and cardiovascular disorders are alarming. This calls for alternative therapies that can attenuate these complications. Therefore, we investigated the beneficial effects of okra on glycaemic control in pre-diabetes and type 2 diabetes mellitus (T2D).Methods: MEDLINE and Scopus were searched for relevant studies. Collected data were analysed using RevMan and reported as mean difference and 95% confidence intervals (CI). Eight studies, including 331 patients with pre-diabetes or T2D, were eligible.Results: Our findings showed that okra treatment reduced the levels of fasting blood glucose: mean difference (MD) = −14.63 mg/dL; 95% CI (-25.25, −4.00, p = 0.007); I2 = 33%, p = 0.17 compared to placebo. Glycated haemoglobin, however, did not differ significantly between the groups: MD = 0.01%; 95%CI (-0.51, 0.54, p = 0.96); I2 = 23%, p = 0.28.Conclusion: this systematic review and meta-analysis found that okra treatment improves glycaemic control in patients with pre-diabetes or T2D. The findings suggest that okra may be used as a supplemental dietary nutrient, especially in pre-diabetic and T2D patients due to its potential to regulate hyperglycaemia.
Deciphering the rhizosphere bacteriome associated with biological control of tobacco black shank disease
Authors: Ma Yi-Nan , Gu Yi-Lin , Liu Jing , Zhang Yuqin , Wang Xinwei , Xia Zhenyuan , Wei Hai-Lei 
Published: April 2023

IntroductionThe black shank disease seriously affects the health of tobacco plants. Conventional control methods have limitations in terms of effectiveness or economic aspects and cause public health concerns. Thus, biological control methods have come into the field, and microorganisms play a key role in suppressing tobacco black shank disease.MethodsIn this study, we examined the impact of soil microbial community on black shank disease basing on the structural difference of bacterial communities in rhizosphere soils. We used Illumina sequencing to compare the bacterial community diversity and structure in different rhizosphere soil samples in terms of healthy tobacco, tobacco showing typical black shank symptoms, and tobacco treated with the biocontrol agent, Bacillus velezensis S719.ResultsWe found that Alphaproteobacteria in the biocontrol group, accounted for 27.2% of the ASVs, was the most abundant bacterial class among three groups. Heatmap and LEfSe analyses were done to determine the distinct bacterial genera in the three sample groups. For the healthy group, Pseudomonas was the most significant genus; for the diseased group, Stenotrophomonas exhibited the strongest enrichment trend, and Sphingomonas showed the highest linear discriminant analysis score, and was even more abundant than Bacillus; for the biocontrol group, Bacillus, and Gemmatimonas were the largely distributed genus. In addition, co-occurrence network analysis confirmed the abundance of taxa, and detected a recovery trend in the network topological parameters of the biocontrol group. Further functional prediction also provided a possible explanation for the bacterial community changes with related KEGG annotation terms.DiscussionThese findings will improve our knowledge of plant-microbe interactions and the application of biocontrol agents to improve plant fitness, and may contribute to the selection of biocontrol strains.
Psychological resilience and cognitive reappraisal mediate the effects of coping style on the mental health of children
Authors: Han Fulei , Duan Ruirui , Huang Beibei , Wang Qiulin 
Published: April 2023

IntroductionThis study explored the effects of coping style and two potential intermediately factors (cognitive reappraisal and psychological resilience) on the mental health of middle school students during the normalization of epidemic prevention and control in China.MethodsAnswers on questionnaires designed to assess coping style, cognitive reappraisal, psychological resilience, and mental health among 743 middle school students (386 boys, 357 girls, 241 first graders, 235 second graders, and 267 third graders) were analyzed using structural equation modeling.ResultsThe results showed that coping style, cognitive reappraisal, and psychological resilience directly predicted mental health. The negative effect of a negative coping style on mental health was significantly stronger than the positive effect of a positive coping style. Coping style affected mental health through the independent mediating effects of cognitive reappraisal and psychological resilience and through their chain mediation.DiscussionThe use of positive coping styles by most students led to greater cognitive reappraisal, strengthened psychological resilience, and thus few mental health problems. These findings provide empirical evidence and may guide educators in the prevention and intervention of mental health problems among middle school students.
Malnutrition is associated with increased disease risk in older people in the Makkah region of Saudi Arabia: A cross-sectional study
Authors: Althaiban Maha A. , Aljefree Najlaa M. , Almoraie Noha M. , Shatwan Israa M. 
Published: April 2023

IntroductionThere is little research on the nutritional status of older people in Saudi Arabia. This study investigated the factors associated with the nutritional status of older people in the Makkah region, Saudi Arabia. We hypothesized that older people who are at risk of malnutrition are at higher risk of different diseases.Materials and methodsThis cross-sectional study surveyed 271 people aged ≥60 years from October 2021 to January 2022. We collected data on demographics, body mass index, the Geriatric Depression Scale-Short Form, Geriatric Oral Health Assessment Index, Mini Nutritional Assessment, Eating Attitudes Test, and Household Dietary Diversity score.ResultsAmong the 271 participants, 13.3% were malnourished and 53.9% were at risk of malnutrition. The oral health (P &lt; 0.001), depression (P &lt; 0.001), and eating disorder (P &lt; 0.002) scores were significantly associated with malnutrition. Congestive heart failure, asthma, peripheral vascular disease, Alzheimer's disease, and hypertension were more prevalent among malnourished participants—this supports our original hypothesis. The HDD score showed no significant differences between men and women.ConclusionMalnutrition was associated with overweight or obesity, poor oral health, and depression. Older people in the Makkah region, Saudi Arabia, had a high risk of malnutrition.
Feed efficiency in dairy sheep: An insight from the milk transcriptome
Authors: Suárez-Vega Aroa , Frutos Pilar , Gutiérrez-Gil Beatriz , Esteban-Blanco Cristina , Toral Pablo G. , Arranz Juan-José , Hervás Gonzalo 
Published: April 2023

IntroductionAs higher feed efficiency in dairy ruminants means a higher capability to transform feed nutrients into milk and milk components, differences in feed efficiency are expected to be partly linked to changes in the physiology of the mammary glands. Therefore, this study aimed to determine the biological functions and key regulatory genes associated with feed efficiency in dairy sheep using the milk somatic cell transcriptome.Material and methodsRNA-Seq data from high (H-FE, n = 8) and low (L-FE, n = 8) feed efficiency ewes were compared through differential expression analysis (DEA) and sparse Partial Least Square-Discriminant analysis (sPLS-DA).ResultsIn the DEA, 79 genes were identified as differentially expressed between both conditions, while the sPLS-DA identified 261 predictive genes [variable importance in projection (VIP) &gt; 2] that discriminated H-FE and L-FE sheep.DiscussionThe DEA between sheep with divergent feed efficiency allowed the identification of genes associated with the immune system and stress in L-FE animals. In addition, the sPLS-DA approach revealed the importance of genes involved in cell division (e.g., KIF4A and PRC1) and cellular lipid metabolic process (e.g., LPL, SCD, GPAM, and ACOX3) for the H-FE sheep in the lactating mammary gland transcriptome. A set of discriminant genes, commonly identified by the two statistical approaches, was also detected, including some involved in cell proliferation (e.g., SESN2, KIF20A, or TOP2A) or encoding heat-shock proteins (HSPB1). These results provide novel insights into the biological basis of feed efficiency in dairy sheep, highlighting the informative potential of the mammary gland transcriptome as a target tissue and revealing the usefulness of combining univariate and multivariate analysis approaches to elucidate the molecular mechanisms controlling complex traits.
Revolutionizing the Public Health Workforce—A Policy Brief in Retrospect of the World Congress on Public Health Rome 2020
Authors: Bürkin Barbara Maria , Venticich Pete Milos , Adongo Philip Baba , De Almeida-Filho Naomar , Magaña Laura , Middleton John , Souza Luis Eugenio , Czabanowska Katarzyna 
Published: April 2023

Background: The COVID-19 pandemic dramatically illustrates the consequences of inadequate prioritization of the Public Health Workforce (PHW). This Policy Brief introduces a Call for Action following the plenary session entitled “Revolutionising the Public Health Workforce (PHW) as Agents of Change” as part of the 2020 World Congress on Public Health.Policy Options and Recommendations: In order to revolutionize the PHW, five long-term key approaches are proposed: 1. Transforming public health competencies through transdisciplinary education and inter-professional training; 2. Revolutionizing educational systems by shifting the public health paradigm; 3. Linking public health education and work opportunities; 4. Overcoming the paradoxical shortage and overproduction of graduates and 5. Developing adaptable, multisectoral agents of change.Conclusion: Public health education of the future requires a paradigm shift towards a holistic understanding of public health, characterized by transdisciplinary education, inter-professional training and a closer integration of academia, health services, and communities.
The Bacterial Volatile Organic Compound N,N-Dimethylhexadecylamine Induces Long-Lasting Developmental and Immune Responses throughout The Life Cycle of Arabidopsis thaliana
Authors: Hernández-Soberano Christian , López-Bucio José , Valencia-Cantero Eduardo 
Published: April 2023

N,N-dimethylhexadecylamine (DMHDA) is a bacterial volatile organic compound that affects plant growth and morphogenesis and is considered a cross-kingdom signal molecule. Its bioactivity involves crosstalk with the cytokinin and jasmonic acid (JA) pathways to control stem cell niches and induce iron deficiency adaptation and plant defense. In this study, through genetic analysis, we show that the DMHDA-JA-Ethylene (ET) relations determine the magnitude of the defensive response mounted during the infestation of Arabidopsis plants by the pathogenic fungus Botrytis cinerea. The Arabidopsis mutants defective in the JA receptor CORONATINE INSENSITIVE 1 (coi1-1) showed a more severe infestation when compared to wild-type plants (Col-0) that were partially restored by DMHDA supplements. Moreover, the oversensitivity manifested by ETHYLENE INSENSITIVE 2 (ein2) by B. cinerea infestation could not be reverted by the volatile, suggesting a role for this gene in DMHDA reinforcement of immunity. Growth of Col-0 plants was inhibited by DMHDA, but ein2 did not. Noteworthy, Arabidopsis seeds treated with DMHDA produced more vigorous plants throughout their life cycle. These data are supportive of a scenario where plant perception of a bacterial volatile influences the resistance to a fungal phytopathogen while modulating plant growth.
The effect of calcium toothpastes on the level of oral hygiene and enamel resistance in 12-18-year-old children
Authors: Limina A. P. , Satygo E. A. , Reutskaya K. V. , Hodgibaev J. Sh. 
Published: April 2023

Relevance. Oral hygiene improvement and remineralization stimulation are essential to prevent dental caries in children aged 12-18 y.o.Purpose: to compare the oral hygiene and enamel resistance levels in children using toothpastes based on calcium glycerophosphate and calcium lactate.Materials and methods. The study involved 42 children aged from 12 to 18 years. Twenty patients used Novy Zhemchug with Calcium toothpaste as a home oral care product for two months. Twenty-two patients used Toothpaste R.O.C.S.® Active Calcium for two months. The study determined the plaque control record (O’Leary, 1967) and the SHS (Simple Hygiene Score) by quantitative light-induced fluorescence (Qraypen C™) and enamel resistance test (Okushko V.R., 1984). All results were statistically processed.Results. The study found that the O’Leary plaque control record, SHS and the enamel resistance test results were not statistically significant in both study groups. After two months of observation, the O’Leary plaque control record significantly improved in children of both groups. However, the group using Toothpaste R.O.C.S.® Active Calcium demonstrated significantly better values (59.74 ± 4.12%). The SHS was significantly better after two months of use in the children group using Toothpaste R.O.C.S.® Active Calcium compared to the children group using Novy Zhemchug with Calcium toothpaste. The enamel resistance test score significantly improved in children of both groups over two months. The patients using Toothpaste R.O.C.S.® Active Calcium for two months demonstrated the best enamel resistance score.Conclusion. Toothpaste containing calcium compounds is quite effective for oral hygiene and enamel resistance improvement in children aged 12-18 y.o. The best scores were in groups of children who used toothpaste containing calcium glycerophosphate compared to the children group who used too thpastes containing calcium lactate.
Концепция разработки технологий интегрального развития и укрепления здоровья
Authors: Kozina Zh. L. , Kozin V. Yu 
Published: April 2023

Представлена теоретическая концепция по разработке различных методик и технологий по интегральному гармоничному воздействию на организм для укрепления здоровья, для комплексного развития двигательных и интеллектуальных способностей человека на различных жизненных этапах. Концепция предполагает целостный подход к созданию методик комплексного психологического и физического развития человека. В основе концепции лежит идея, что человек является самоорганизующейся многофункциональной системой. На любое воздействие система отвечает целостно, в большей или в меньшей мере включаются все ее компоненты. Для решения любой жизненной задачи включаются как физический, так и интеллектуальный, психологический, духовный компоненты. поэтому разработка технологий гармоничного развития и укрепления здоровья подразумевают комплексный подход к активизации не только физического, но и сознательного компонентов. При этом ведущая роль принадлежит сознательному компоненту. В качестве примера интегральной технологии представлен авторский комплекс упражнений, выполняемых под стихи, для детей от 1 года до 7 лет, получивший название «Маленькие волшебники». Данная технология получила широкое распространение в различных детских учреждениях. Все авторские технологии, р, прошли экспериментальную проверку и пазработанные согласно представленной концепции, показали свою эффективность.
Аналіз структури інтегральної підготовленості кваліфікованих гандболістів із застосуванням методів багатовимірного аналізу
Authors: Kozina Zh.L. , Bazilyuk T.A. , Boiko A.G. 
Published: April 2023

Мета роботи: визначити факторну структуру підготовленості гандболістів вищих розрядів. Матеріал і методи: В дослідженні взяли участь 25 кваліфікованих гандболістів, вік 23-24 роки. Методи дослідження: аналіз літературних джерел, методи педагогічного тестування, методи фізіологічного тестування (вимір швидкості зорово-моторної реакції, аналіз серцевого ритму, біохімічний аналіз крові на концентрацію гемоглобіна, кортизола та інсуліна, тест PWC170, методи математичної статистики (кореляційний, факторний аналізи) з застосуванням комп'ютерних програм „EXEL” і „SPSS-11”. Результати: Виявлено достовірні середні та високі (0,5-0,9) коефіцієнти взаємозв’язку між точністю кидків та швидкістю пробігання 6-ти - метрового відрізку, стрибком з місця, метанням набивного м’яча з розбігу, швидкістю реакції, концентрацією β-ендорфінів, гемоглобіну, абсолютними та відносними значеннями PWC170, активністю симпатичного відділу вегетативної нервової системи за показниками серцевого ритму. Показано, що показники розширеного комплексного тестування гандболістів розбиваються на шість факторів. В перший і найголовніший фактор увійшли показники швидкісно-силової підготовленості та точності кидків в поєднанні з антропометрічними даними. Висновки. При навчанні основним технічним прийомам в гандболі слід робити акцент не тільки на просторово-часових параметрах технічних рухів, але й на швидкісно-силовому аспекті їх виконання. Це потребує розробки відповідних методик навчання.
Методика формування техніки кидків з середньої відстані у баскетболі
Authors: Kozina Zh.L. , Grin' L.V. , Vasilyev Yu.K. , Natarov V.A. , Dolgareva M.G. 
Published: April 2023

Мета роботи: розробити методику навчання кидку однією рукою від плеча і перевірити ефективність її застосування на уроках фізкультури в 6-х класах. Матріал і методи. У дослідженні взяли участь 62 школяра 6 класів, з них 31 учень увійшли експериментальної групи, 31 – до контрольної. Методи дослідження: аналіз науково-методичної літератури, відеозйомка з наступною комп'ютерною обробкою матеріалу, педагогічні спостереження, тестування, метод математичної статистики з застосуванням комп'ютерних програм „EXEL” і „SPSS-11”, педагогічний експеримент. Результати. Розроблена методика є досить ефективною для навчання школярів 6-х класів кидку однією рукою від плеча. Після проведеного експерименту результативність підвищилася в експериментальній групі до 6 улучень із правої сторони (t=6,8; р<0,001), з лівої сторони – до 5,7 (t=6,8; р<0,001) при достовірному зменшенні кількості помилок. Наприкінці експерименту якість володіння технікою кидка однією рукою від плеча з місця в експериментальній групі виявилося вище, ніж у контрольній групі. Випробувані експериментальної групи перевершили випробуваних контрольний групи за всіма показниками (при р<0,001). Висновки. Розроблена методика навчання кидкам із середньої відстані у баскетболі із застосування поліграфічних приладь є більш ефективною у порівнянні з традиційною.
Estrategias formativas en contextos no formales orientadas al desarrollo socioprofesional
Authors: Tejada Fernández José 
Published: April 2023

En el presente artículo se abordan las estrategias formativas en contextos no formales para el desarrollo socioprofesional. Se parte de la no asunción de las lindes tan marcadas entre los diferentes sistemas formales y no formales, por cuanto hoy día la permeabilidad-flexibilidad intersistemas es la característica más evidente.
De alguna forma se apuesta por la formación a lo largo de la vida como enfoque que puede asumir e integrar perfectamente todo lo relativo a los contextos no formales conjuntamente con los formales e informales.
Ubicados en este contexto se conceptualizan las estrategias y se fija el propio referente teórico para llegar a propuesta de clasificación de estrategias formativas ligadas a lógica del desarrollo de la formación basada en competencias. En este sentido se ubican algunas estrategias ligadas al saber (competencia técnica), al saber-hacer (competencia metodológica), al saber-ser (competencia personal) y al saber-estar (competencia participativa), para proponer todo un conjunto de estrategias formativas globales e integradoras de las anteriores.
Gestionar la escuela en Latinoamérica. Gestión educativa, realidad y política
Authors: Tello César Gerónimo 
Published: April 2023

El propósito de este trabajo es analizar determinadas particularidades teóricas acerca de la “gestión educativa” en la realidad latinoamericana, por ello intentaremos desplegar el análisis desde una perspectiva crítica de la administración educativa, de la cual surge el campo de la Gestión Institucional. Al referirnos a perspectiva crítica lo hacemos situándonos en la propia realidad latinoamericana, en oposición a aquello que en este artículo denominamos realidad extraña.Para gestionar se requiere del conocimiento sensible como actitud frente a la realidad. Desde esta perspectiva toda apreciación, definición o conceptualización acerca de la gestión educativa acarrea una posición frente a la realidad, posición pedagógico-política.Por esto se requiere repensar la gestión educativa desde la propia Latinoamérica, dado que aún poseyendo elementos teóricos valiosos, no se adapta en muchos casos a la propia realidad.
Dispersion stability of tin(IV) oxide nanoparticles in polar solvents and water aided by ultrasonication
Authors: Ong Chinkhai , Lee Wengnam , Lim Linghong , Chong Wuyi , Chew Jingwen , Hayashi Yasuhiko , Nishikawa Takeshi , Öhberg Patrik , Ahmad Harith , Yap Yuenkiat 
Published: April 2023

Abstract
Dispersion stability of tin(IV) oxide nanoparticles dispersed in N-Methy-2-Pyrrolidone (NMP), dimethylformamide (DMF) and distilled water assisted by ultrasonication was investigated, aiming to identify a suitable liquid medium to effectively disperse tin(IV) oxide for many useful applications. The dispersions’ stability was characterized using field emission scanning electron microscopy, ultraviolet–visible spectroscopy and Zeta potential. The results show that distilled water has the highest stability with optimum sonication of 1 h. NMP shows better stability and consistency than DMF at different sonication timings. Good agreement between ultraviolet–visible absorbance and Zeta potentials shows that both distilled water and NMP are good mediums to produce highly stable tin(V) oxide dispersion.
Planarization profile modeling using pad bulk deformation and real contact area analysis of macro-scale device pattern
Authors: Jeong Seonho , Jeong Jongmin , Shin Yeongil , Park Youngwook , Kabasawa Masashi , Hiyama Hirokuni , Watanabe Katsuhide , Matsuo Hisanori , Wada Yutaka , Jeong Haedo 
Published: April 2023

Abstract
In general, the shape of the polished pattern is not flat but has a rounded curved profile. Unlike micro-patterns that have similar scales to pad asperities, macro-patterns have a very large scale compared to asperities, so bulk deformation must also be considered. To derive the pad bulk deformation, real contact area (RCA) measurements were performed in this study. Based on the preceding contact model, a semi-empirical model for RCA and bulk deformation was derived. After including the constructed pad bulk deformation function in the existing Greenwood–Williamson model, a new model that can derive the material removal rate profile according to the position in the pattern was presented. Unlike the general upper and lower removal rate behavior, this model shows a unique behavior. At the beginning of polishing, the edge shows a higher removal rate than the center, but after a specific step height, the center has a higher removal rate due to the curved shape. Analysis was performed for comparison between the proposed model equation and the experimental value. When the polishing profile in the 10 mm pattern was compared with the previous model and the proposed model, respectively, the existing model did not predict the removal rate distribution according to the position in the pattern. However, this model has the advantage of predicting both over-polishing at the edge of the pattern and high removal rate at the bottom. In addition, it was confirmed through simulation that the 4 mm and 2 mm patterns had excellent matching properties.