bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improving the developmental competences of porcine parthenogenetic embryos by Notoginsenoside R1‐induced enhancement of mitochondrial activity and alleviation of proapoptotic events
Authors: He Sheng‐Yan , Liu Rong‐Ping , Wang Chao‐Rui , Wang Xin‐Qin , Wang Jing , Xu Yong‐Nan , Kim Nam‐Hyung , Han Dong‐Wook , Li Ying‐Hua 
Published: September 2023

AbstractNotoginsenoside R1 (NGR1), derived from the Panax notoginseng root and rhizome, exhibits diverse pharmacological influences on the brain, neurons, and osteoblasts, such as antioxidant effects, mitochondrial function protection, energy metabolism regulation, and inhibition of oxygen radicals, apoptosis, and cellular autophagy. However, its effect on early porcine embryonic development remains unclear. Therefore, we investigated NGR1's effects on blastocyst quality, reactive oxygen species (ROS) levels, glutathione (GSH) levels, mitochondrial function, and embryonic development‐related gene expression in porcine embryos by introducing NGR1 during the in vitro culture (IVC) of early porcine embryos. Our results indicate that an addition of 1 μM NGR1 significantly increased glutathione (GSH) levels, blastocyst formation rate, and total cell number and proliferation capacity; decreased ROS levels and apoptosis rates in orphan‐activated porcine embryos; and improved intracellular mitochondrial distribution, enhanced membrane potential, and reduced autophagy. In addition, pluripotency‐related factor levels were elevated (NANOG and octamer‐binding transcription factor 4 [OCT4]), antioxidant‐related genes were upregulated (nuclear factor‐erythroid 2‐related factor 2 [NRF2]), and apoptosis‐ (caspase 3 [CAS3]) and autophagy‐related genes (light chain 3 [LC3B]) were downregulated. These results indicate that NGR1 can enhance early porcine embryonic development by protecting mitochondrial function.
Formation of magnesium‐clay in a lacustrine microbialite‐bearing carbonate deposit, Eocene Green River Formation, Sanpete County, Utah
Authors: Cupertino Daniel F. , Ramnani Camila Wense , Vanden Berg Michael D. , Awramik Stanley M. 
Published: September 2023

AbstractAuthigenic magnesium‐clays have been observed and documented in the Green River Formation, specifically as ooidal stevensite grains. Magnesian clays are a valuable proxy for reconstructing shallow‐water, saline–alkaline lake palaeoenvironments due to their responses to chemical changes. Magnesium‐rich clay minerals are relatively common components in modern and ancient lake systems. A rare interaction of lacustrine magnesian clays, microbialites, carbonates and volcanoclastic deposits of the Eocene Green River Formation crop out in Sanpete Valley, Utah, USA. The characterization of this interaction, Mg‐rich clay and carbonate minerals genesis, the environmental controls on Mg‐rich clay minerals distribution and accumulation is still poorly understood. This study has identified various species of Mg‐clay minerals (stevensite, mixed‐layer kerolite–stevensite and sepiolite), along with calcite and dolomite, found in four Mg‐clay‐bearing lithofacies: (i) Mg‐clay stromatolites; (ii) Mg‐clay arenites; (iii) Mg‐claystone; and (iv) intraclastic Mg‐clay hybrid arenites and conglomerates. Magnesium‐clay bearing rocks from the Sanpete Valley area were deposited in a south‐western, shallow embayment of Eocene Lake Uinta along the margin of the Sevier fold and thrust belt. Sanpete Valley's Mg‐clay‐bearing section shows syngenetic mineralogical paragenesis with neoformation of magnesian clays accompanied by calcite and silica. Regional chronostratigraphic correlation of Sanpete Valley's Mg‐clay‐bearing section with the Uinta Basin was made by zircon U–Pb dating (laser ablation–inductively coupled plasma–mass spectrometry) of two tuff beds. Stevensite and kerolite are precipitated under very specific conditions. This study presents a depositional model, considering evidence from the authigenic mineralogy, facies, fossil evidence and basin context. All of these findings allow a comprehensive analysis of the lithostratigraphic and chemostratigraphic evolution of this isolated bay system, as well as texture classification. This study provides analogue for detailed correlation and comparison to other basins containing similar Mg‐clay and microbialite‐bearing deposits.
Gravitational resedimentation as a fundamental process in filling fjords: Lessons from outcrops from a late Palaeozoic fjord in Namibia
Authors: Menozzo da Rosa Eduardo , Isbell John L. , McNall Natalie , Fedorchuk Nicholas , Swart Roger 
Published: September 2023

AbstractThe stratigraphic architecture of fjords is complicated due to the delicate interplay between ice dynamics, sediment supply, relative sea‐level fluctuations and slope failures. Glaciogenic sediment is prone to failure and to be carried downslope to the fjord floor through the entire spectrum of mass movements and subaqueous density flows, as the unstable paraglacial submarine landscape moves towards stability. Palaeofjords formed by Gondwanan glaciers during the late Palaeozoic Ice Age contain a compelling record of gravitational resedimentation in fjord depositional systems. This paper showcases the geomorphology and depositional history of a glacial cycle in the Orutanda fjord in north‐western Namibia as an example of an overdeepened fjord basin fill dominated by products of subaqueous gravitational processes. During glaciation, the Orutanda glacier carved a 20 km long by 3.7 km wide glacial trough that embodies an overdeepened basin. Ice thickness during terminal glacial occupation of the fjord is estimated to had been up to 200 m based on the fjord geomorphology. The progressive retreat of the tidewater glacier, concomitant with marine flooding, increased accommodation space in the overdeepened basin during deglaciation. During this stage, proglacial sedimentation through iceberg rafting and settling of turbid plumes was outpaced by intense paraglacial downslope resedimentation of glacially‐transported debris. Successive failures from the fjord walls and downslope resedimentation resulted in coalescing debrite–turbidite lobes on the fjord floor. Slide deposits, composed entirely of deformed debrites and turbidites, indicate that these resedimented facies were prone to renewed mass wasting. As the Orutanda glacier melted, the fjord experienced the axial progradation of a fjord‐head delta registered only by turbidites and slide deposits derived from its collapse. The Orutanda fjord sheds light on the relevance of paraglacial mass wasting in overprinting glaciogenic deposits. This insight is key to understanding the role of glaciers versus non‐glacial processes in producing the glacial deep‐time record.
Successful treatment of Rhodococcus lung abscess and empyema thoracis in a heart transplant recipient
Authors: Namsiripongpun Warunyu , Yingchoncharoen Teerapat , Ngodngamthaweesuk Montien , Sukprapruet Araya , Naratreekoon Bundit , Bruminhent Jackrapong 
Published: September 2023

AbstractRhodococcosis is an uncommon cause of pulmonary infection in thoracic organ transplant recipients. We describe a heart transplant recipient diagnosed with Rhodococcus equi left upper lung abscess with empyema thoracis complicated by bacteremia. The patient was successfully treated with appropriate antibiotics, adequate surgical resection, and optimization of immunosuppressants.
Noninvasive screening of fetal RHD genotype in Chinese pregnant women with serologic RhD‐negative phenotype
Authors: Duan Honglei , Li Jie , Jiang Zihan , Shi Xiaohong , Hu Yali 
Published: September 2023

AbstractBackgroundNoninvasive fetal RHD genotyping has been provided to nonimmunized RhD‐negative pregnant women to guide anti‐D prophylaxis. Among the Chinese, more than 30% of the RhD‐negative phenotype is associated with variant RHD alleles, which would limit the accuracy of fetal RHD status prediction; thus, more targeting and proper programs need to be developed.Study Design and MethodsFluorescence quantitative polymerase chain reaction PCR (qPCR) or Sanger sequencing on all RHD exons was used to detect maternal RHD genotypes. For pregnant women with RHD*01N.01 or RHD*01N.03 alleles, the presence of RHD exons 5 and 10 in cell‐free DNA was determined by qPCR. For pregnant women with the RHD(1227G>A) allele, high‐throughput sequencing on exon 9 of the RHD gene and RHCE gene was used to predict fetal RhD phenotype.ResultsAmong 65 cases of Chinese pregnant women with the serologic RhD‐negative phenotype, three major genotypes were identified: RHD*01N.01/RHD*01N.01 (61.5%), RHD*01N.01/RHD(1227G>A) or RHD*01N.03/RHD(1227G>A) (20%), and RHD*01N.01/RHD*01N.03 (13.8%), along with three cases of minor genotypes (4.6%). For 43 pregnant women with the RHD*01N.01 or RHD*01N.03 alleles, qPCR on maternal cell‐free DNA yielded a 98.5% (42/43) accuracy rate and 100% successful prediction rate. High‐throughput sequencing was successfully used to predict fetal RhD phenotypes for 13 pregnant women with RHD(1227G>A).ConclusionOn the basis of maternal RHD genotyping, fetal genotyping through qPCR or high‐throughput sequencing can improve the accuracy and success rate of prenatal fetal RhD phenotype prediction among Chinese pregnant women. It plays a potential role in guiding anti‐D prophylaxis and pregnancy management in Chinese pregnant women.
The least developed countries' Services Waiver, Aid for Trade for services and services exports
Authors: Gnangnon Sèna Kimm 
Published: September 2023

AbstractIn 2011, Trade Ministers of the World Trade Organisation (WTO) adopted a Decision that allows WTO Members to accord preferential treatment to services and service suppliers originating in least‐developed countries (LDCs). In 2013, another Ministerial Decision was adopted to operationalise the 2011 Waiver Decision. This paper has examined whether the Waiver Decision had been effective in promoting LDCs' commercial modern and traditional services exports and whether Aid for Trade (AfT) flows in favour of the services sectors were instrumental in achieving this objective. The analysis has used 43 LDCs over the period 2005–2018 and the difference‐in‐difference framework along with the two‐step system generalised method of moments estimator. The control group includes 20 Low‐Income Countries (designated as such by the International Monetary Fund) from which LDCs (as defined by the United Nations) are excluded. The analysis has revealed that the Waiver Decision led to higher modern commercial services exports at the expense of traditional commercial services exports. Moreover, as LDCs improved their trading capacity over time (thanks to the cumulative AfT flows for services), the Waiver Decision induced greater modern commercial services exports, but exerted a mixed effect on LDCs' traditional services exports.
A BROADER PERSPECTIVE ON “HUMANS”: ANALYSIS OF INSĀN IN TWELVER SHĪʿĪ PHILOSOPHY AND IMPLICATIONS FOR ASTROTHEOLOGY
Authors: Ansar Abdullah , Haider Shahbaz 
Published: September 2023

AbstractThis article explores the essence of the human (insān) as it is understood in Twelver Shīʿī philosophy and mysticism. It presents a Shīʿī philosophical elucidation regarding the possible existence of extraterrestrial intelligent lifeforms and what their relationship with “humanhood” might be. This line of reasoning is presented with a general sketch of how, in Shīʿī Islamic thought, a “human being” is characterized by specific traits and the relationship of human beings with the archetype of the Perfect Human (al‐Insān al‐Kāmil). Following this is a review of Shīʿī Imāmī traditions regarding extraterrestrial intelligent life and the plurality of worlds. This sequence ultimately allows for a unique analysis of humanhood according to the Shīʿī philosophical viewpoint and helps determine if the term “human” can be used for other intelligent beings with similar ontological features and intelligence levels.
Wearable Sleep Monitoring System Based on Machine Learning Using Snoring Sound Signal
Authors: Xin Yi , Li Rui , Song Xuefeng , Wang Yuqi , Zhang Hanshuo , Chen Zhiying 
Published: September 2023

Abstract
According to the obstructive sleep apnea Syndrome (OSAS), a wearable sleep monitoring system is designed based on machine learning using snoring sound signal. The system picks up snoring signal via bone conduction sensor, and calculates the apnea-hypopnea index (AHI). By analyzing the snoring signal in frequency domain, spectral entropy and other frequency-domain features are selected. Finally, the neural network classifier model is established. In the model, the input variables are eight frequency-domain features, and the output response is related to AHI value. Trained by machine learning, the result shows that the average accuracy in identifying the severity of the four kinds of OSAS categories is 59%. The system uses the measured data of snoring to analyze the symptoms of OSAS, so as to realize the preliminary forecast based on the snoring data. The system proposed in this paper has a good application development prospect in intelligent monitoring and medical instruments.
A Two-Stage Magnetically Enhanced Buoyancy Adjustment Actuator Based on Dielectric Elastomer
Authors: Cao Xunuo , Zhuo Jiangshan , Zou Weifeng , Li Xinge , Ruan Dongrui , Yang Xuxu , Zhou Fanghao , Li Tiefeng 
Published: September 2023

Abstract
The buoyancy adjustment capability is crucial for underwater robots. Dielectric elastomer (DE) is promising to be designed as inflatable actuators to achieve quiet, fast, and effective buoyancy adjustment. However, the buoyancy adjustment of DE actuators is limited by voltage amplification and controllability. This paper presents to solve the limitation of the DE buoyancy adjustment actuator by magnetic enhancement. An actuator is designed with a two-stage buoyancy adjustment capability. The two-stage adjustment strategy allows the actuator to achieve higher buoyancy adjustment at low voltage and controllable buoyancy adjustment at high voltage, where the switch between the two stages is achieved by tuning the snap of the magnet. A theoretical model is developed to assess the performance of the actuator in the two stages and describe the snap behavior. The experiment results agree with the simulation, and the actuator demonstrates the ability to adjust attitude by changing buoyancy at high voltages and rapidly ascending at low voltages. The multiple buoyancy adjustment capabilities of this actuator have the potential to enable the underwater robot to fulfill various complex task demands.
Effect of Hydrogen Enrichment on Transfer Matrices of Fully and Technically Premixed Swirled Flames
Authors: Blondé Audrey , Schuermans Bruno , Pandey Khushboo , Noiray Nicolas 
Published: September 2023

Abstract
Knowledge of flame responses to acoustic perturbations is of utmost importance to predict thermoacoustic instabilities in gas turbine combustors. However, measuring transfer functions linking acoustic quantities upstream and downstream of flames are very challenging in practical systems and these measurements can significantly deviate from state-of-the-art models. Moreover, there is a lack of studies investigating the effect of hydrogen enrichment on the response of natural gas (NG) flames. In this work, measurements of flame transfer matrices (FTMs) of turbulent H2/NG flames in an atmospheric combustor featuring an axial swirler burner have been performed, allowing us to unravel the transition between FTM in fully premixed (FP) and in technically premixed (TP) conditions. Furthermore, imaging of OH* chemiluminescence and OH-planar laser induced fluorescence are obtained for characterizing the topology of the flame for varying H2 fraction and mixing conditions. Transfer matrices are measured using the multimicrophone method for H2 fractions ranging from 12% to 43% in power. Afterward, the flame transfer functions (FTFs), which linearly relate the coherent fluctuations of the heat release rate to the acoustic velocity oscillations, are obtained from the FTM by using the Rankine–Hugoniot jump conditions across the flame. Using the OH* chemiluminescence intensity as a surrogate for the heat release rate, the FTF based on this optical measurement is also extracted and compared to the one exclusively obtained with the multimicrophone method. As expected, the two different methods are in very good agreement for the FP case and significantly differ for the TP case. Indeed, chemiluminescence fluctuations cannot be directly linked to heat release rate fluctuations when the acoustic forcing induces equivalence ratio fluctuations at the flame, making the optical method unusable for TP configurations. We also show that the two methods agree in the high end of the explored excitation frequency range and we provide an explanation to this intriguing finding. Moreover, we investigate the sensitivity of the FTM measurement to the estimate of the speed of sound in the rig in FP conditions. Finally, the measured FTFs are fitted with FTF models based on multiple distributed time delays. This allows us to explain the frequency dependence and the hydrogen fraction dependence of the gain and the phase in FP and TP conditions.
Ceramic and Metal Additive Manufacturing of Monolithic Rotors From SiAlON and Inconel and Comparison of Aerodynamic Performance for 300W Scale Microturbines
Authors: Badum Lukas , Prochaska Thomas , Schwentenwein Martin , Cukurel Beni 
Published: September 2023

Abstract
The gas turbine industry is continuously developing and testing new materials and manufacturing methods to improve the performance and durability of hot section components, which are subjected to extreme conditions. SiAlON and Inconel 718 are especially desirable for turbomachinery applications due to their high strength and high-temperature capabilities. To demonstrate the viability of additive manufacturing for small-scale turbomachinery for 300W scale microturbines, a monolithic rotor with a design speed of 450,000 RPM containing radial turbine and compressor was developed considering additive manufacturing constraints. The geometry was manufactured from SiAlON and Inconel 718 using lithographic ceramic manufacturing and selective laser melting, respectively. The additive manufacturing and thermal process parameters as well as material characterization are described in detail. Surface and computerized tomography scans were conducted for both rotors. While the metallic rotor showed undesirable printing artifacts and a large number of defects, the ceramic part achieved a level of relative precision and surface quality similar to large-scale production via casting. To compare turbomachinery performance, an aerodynamic test facility was developed allowing to measure pressure ratios and efficiency of small compressors. The rotors were tested in engine-realistic speeds, achieving a compressor rotor pressure ratio of 2.2. The ceramic part showed superior efficiency and pressure ratio compared to the Inconel rotor. This can be explained by lower profile and incidence losses due to a higher fidelity physical representation of the model geometry and better surface finish.
Daily fosfomycin versus levofloxacin for complicated urinary tract infections
Authors: Rouphael Nadine , Winokur Patricia , Keefer Michael C. , Traenkner Jessica , Drobeniuc Ana , Doi Yohei , Munsiff Sonal , Fowler Vance G. , Evans Scott , Oler Randolph E. , Tuyishimire Bonifride , Lee Marina , Ghazaryan Varduhi , Chambers Henry F. ,   DMID 15-0045 study group, Esper Annette , Rebolledo Paulina A. , Wiley Zanthia , Jacob Jesse T. , Mehta Aneesh , Kraft Colleen S , Wang Yun F , Bou Chaaya Rody G. , Fayad Danielle , Bechnak Amer , Macenczak Hollie , Dretler Alexandra , McCullough Michele Paine , Johnson Sara Jo , Beydoun Nour , Saklawi Youssef , Mulligan Mark , Alaaeddine Ghina , Bunce Catherine , Hardy Dwight , Antenozzi Susan , Moran Andrew , Almuntazar-Harris Malcolm , Wall Alison , Sumerel John , Kreder Karl , Takacs Elizabeth B. , Adler David , Mueller Margaret 
Published: September 2023

ABSTRACT
Fosfomycin, approved in the United States only for cystitis, is an attractive alternative for oral treatment of outpatient complicated urinary tract infections (cUTIs) as it has antimicrobial activity against most common uropathogens. The study was a multicenter, randomized, open-label pragmatic superiority clinical trial evaluating the efficacy of oral fosfomycin versus oral levofloxacin strategies in cUTIs (FOCUS study). The trial compared two strategies for initial or step-down oral therapy of cUTI without bacteremia after 0–48 hours of parenteral antibiotic therapy. Subjects were assigned to 3 g of fosfomycin or 750 mg (or dose adjusted for kidney function) of levofloxacin daily for 5–7 days. Clinical and microbiological cures were assessed at the end of therapy (EOT) and test of cure (TOC) (approximately 21 days from the start of antibiotics). The trial did not meet accrual goals; thus, the results were descriptive. Only 51 subjects were included in the microbiological intention-to-treat population. The subjects were mainly females (76%), with a mean age of 46.7 years (standard deviation [SD] = 20.8) and acute pyelonephritis (88%). At the end of therapy, clinical cure remained similar (69% and 68% for fosfomycin and levofloxacin strategies, respectively), and microbiological success was 100% for both strategies. At the test of cure, clinical cure was similar (84% and 86% in the fosfomycin and levofloxacin strategies, respectively); however, a numerically lower microbiological success was observed for fosfomycin (69% compared to 84% for levofloxacin). These limited data suggest that fosfomycin could be an oral alternative as a step-down therapy for the treatment of cUTIs (registry number NCT 03697993).

IMPORTANCE
Concerns over resistance and safety have been identified in the current treatment regimen for complicated urinary tract infections. Fosfomycin is a drug that is routinely used for the treatment of uncomplicated cystitis. This study shows that fosfomycin could be an oral alternative as step-down therapy for the treatment of complicated urinary tract infections, with a clinical cure rate comparable to levofloxacin but a lower microbiological success rate 3 weeks from start of antibiotics.