bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of 14 β-agonists in pork using automated wooden tip based SPME device and UPLC-MS/MS
Authors: Li Kai , Gong Xiaoming , Jin Liming , Liu Mengxiao , Hua Mengmeng 
Published: August 2023

Abstract
This study presents an innovative analytical method for the detection and quantification of 14 β-agonists in pork using liquid chromatography-tandem mass spectrometry (LC-MS/MS). The method involves the use of a solid phase microextraction (SPME) probe, consisting of a wooden tip coated with polyacrylonitrile (PAN) and molecularly imprinted polymer (MIP). This probe has been integrated into an automated extraction device, designed in our laboratory to extract the target analytes prior to LC-MS/MS analysis. Compared to the traditional solid-phase extraction (SPE) procedure, the proposed approach significantly reduces the costs related to adsorbent material and solvent consumption, and shortens purification time, thereby reducing both the technical workload and associated expenses. The methodology has been carefully validated in accordance with the National Standard of the People's Republic of China (GB/T 22286-2008), evaluating key parameters including the limit of detection (LOD), limit of quantification (LOQ), matrix effects, linearity, and both intra-day and inter-day precision. The average recovery rates for all β-agonists were observed to lie between 71.6% and 82.2%, with relative standard deviations (RSDs) consistently below 15% for both types of precision. The LOD and LOQ values were found to range from 0.09 to 0.39 μg/kg and 0.27 to 0.99 μg/kg, respectively. In terms of accurate detection of positive samples, the developed method demonstrated a closer approximation to the true value of the sample compared to the National Standard method GB/T 31658.22-2022. Overall, the proposed method exhibits substantial promise for the routine assessment of β-agonists in pork and presents a practical alternative for compliance monitoring in regulatory settings.
Spatiotemporal variations in seismic activity in and around the focal region of the 2021 M7.3 and 2022 M7.4 Fukushima-Oki earthquakes, Japan
Authors: Chiba Keita 
Published: August 2023

Abstract
The spatiotemporal evolution of seismic activity is presented for a broad region surrounding the focal areas of the 2021 M 7.3 and 2022 M 7.4 Fukushima-Oki earthquakes, which occurred within the subducting slab off the Pacific coast of Fukushima Prefecture, northeastern Japan. This study investigates the spatiotemporal variations in seismic activity during the periods before the 2021 M 7.3 earthquake, between the 2021 M 7.3 and 2022 M 7.4 earthquakes, and after the 2022 M 7.4 earthquake using the b -value of the Gutenberg–Richter relation, the aftershock decay rate ( p -value), and changes in the seismicity rate (Z -value). The study area is also divided into two depth sections to investigate the depth variations in these seismicity parameters relative to the plate interface. The b -values in the deeper section (intraslab) are generally lower than those in the shallower section (around the plate interface) throughout the entire analysis period, including the hypocentral areas of the M 7.3 and M 7.4 earthquakes. The aftershock decay rates for the M 7.3 and M 7.4 earthquakes also show depth-dependent characteristics, with a slower decay rate ( p < 1.0) at many grid nodes in the deeper section than in the shallower section. Furthermore, seismic quiescence was noted in the hypocentral area of the M 7.3 earthquake about two years before the occurrence of this mainshock. The locations of the M 7.3 and M 7.4 earthquakes around the down-dip edge of the slip area of the 2011 M 9.0 Tohoku earthquake suggests that the variations in seismic activity detected in this study mainly reflect stress increases due to the coseismic slip and postseismic deformation of this great earthquake. The present study suggests that the effect of viscoelastic relaxation is a dominant factor in the deeper section. Furthermore, the variations in seismicity may also reflect heterogeneous structures within the slab.
Reproduction Rate and Viability of Nilagiri and Nilagiri Synthetic Breeds of Sheep
Authors: Chaudhari Arth Bhaljibhai , Ramanujam Rajendran , Ragothaman Venkataramanan , Sundaram S. Meenakshi 
Published: August 2023

Abstract
Reproduction data of 4648 Nilagiri and 6542 Nilagiri Synthetic ewe records spreads over 27 years (from 1989 to 2015) representing 4530 Nilagiri and 5950 Nilagiri Synthetic breeding ewes were used in this study. Flocks belonged to the Sheep Breeding Research Station, Sandynallah, India. Flock dynamics of six age groups (1.5–7.5 yrs) were assessed. Ultimate objective of this research work was to evaluate the replacement rate, reproduction rate, flock structure and dynamics of Nilagiri and Nilagiri Synthetic sheep breeds. Three parameters were used to evaluate flock dynamics, age specific replacement rate, net reproduction rate and intrinsic rate of increase or innate capacity for increase of population. The replacement rate estimated was significantly higher (P value < 0.002) in Nilagiri (0.289) than Nilagiri Synthetic sheep (0.260). The age-specific death rates ranged from 0.026 (3.5–4.5 years) to 0.191 (6.5–7.5 years) with highest 0.191 and 0.134 in Nilagiri and Nilagiri Synthetic sheep from 1.5 to 7.5 years of age, respectively. The replacement requirements will be met if the ewes are kept in the flock until five years of age with a net reproduction rate of 1.024 in Nilagiri and if the ewes are kept in the flock until six years of age with a net reproduction rate of 1.196 in Nilagiri Synthetic. Nilagiri ewes in intermediate ages had more multiple births and older ewes weaned more lambs. The flock strength was not maintained unless the ewes were kept till the fifth lambing Nilagiri, third lambing in Nilagiri Synthetic sheep. All estimates tended to increase with dams age up to six years and decreased thereafter. The results of Ro and rm showed that the studied flock must consist of 6 age groups to maintain its size and replace itself. It may be recommended to cull the breeding ewe at the age of 6 years to accelerate genetic improvement. Based on the findings it is concluded that suitable breeding policy of selection and culling of such flock should be formulated.
SOL EL KULLANICISI DİŞ HEKİMLİĞİ ÖĞRENCİLERİNDE DÖNÜŞTÜRÜLEBİLİR DENTAL ÜNİTLERDE EĞİTİM KALİTESİNİN DEĞERLENDİRİLMESİ
Authors: GEDUK Gediz , KOCAK Murat , BODRUMLU Emre , SAĞLAM Baran Can 
Published: August 2023

ÖZ
Amaç
Lateralite, insanlarda her bir serebral yarımkürede ve kontrol ettiği vücut bölgesinde özelleşmiş bir işleyişin gelişimini içeren belirli bir farklılığı ifade eder. Lateralitenin en sık karşılaşılan ve dikkat çeken tipi ise el tercihidir. Bu çalışmanın amacı, bir diş hekimliği fakültesindeki sol el kullanıcısı diş hekimliği lisans öğrencilerinin dönüştürülebilir diş ünitlerinde klinik eğitim ve hizmet kalitesini değerlendirmektir.
Gereç ve yöntemler
Bu araştırma Diş Hekimliği Fakültesinde öğrenim gören dönem 4 ve dönem 5 öğrenciler içerisinde sol el kullanıcısı olan 22 öğrencinin gönüllü olarak katılımıyla gerçekleştirilmiştir. Yapılan anket öncesinde öğrencilere anket hakkında bilgi verilmiş olup gönüllülük esası aranmıştır.
Bulgular
Hazırlanan ankete toplamda 22 öğrenci gönüllülük esaslarına göre cevap vermiştir. Bunun üzerine cevap verilen her soru tek tek incelenip sol el kullanıcı hekimlik ve dönüştürülebilir ünitler ile ilgili neticelere varılmaya çalışılmıştır.
Sonuç
Sonuç olarak, sol el kullanıcısı diş hekimliği öğrencilerinde dönüştürülebilir dental ünitler eğitim kalitesini olumlu yönde etkilemektedir.
Effect of different single file systems on the dentin thickness in the danger zone of mandibular first molars
Authors: AKTEMUR TÜRKER Sevinç , GEDUK Gediz , GÖZCÜ Cem 
Published: August 2023

Background: To compare the dentin thickness in the danger zone of mandibular molars after preparation with one rotating (XP-endo Shaper) and two reciprocating (One Reci and Reciproc Blue) single file systems using a cone beam computed tomography (CBCT).
Materials and Methods: Thirty-six mesial roots of mandibular first molars having two independent canals were selected. After initial CBCT scans were provided, teeth were assigned into 3 groups related to the single file used: XP-Endo Shaper (XPS), One Reci (OR) and Reciproc Blue (RB). The roots were scanned again after preparation with respective single file systems. The minimum dentine thickness in the danger zone, at 4, 5, 6 and 7 mm below the furcation level, were measured in CBCT scans. Initial and final measurements were used to calculate the removed dentin thickness in the danger zone. Data was analyzed using Repeated-measures ANOVA (p=0.05).
Results : No significant differences were found related with remaining and removed dentin thickness among single file systems at any level from the furcation (p>0.05).
Conclusions: The evaluated single file systems showed similar cutting efficiency in the danger zone of mandibular molars.
NIE KAŻDY MUSI BYĆ DOKTOREM PRAWA, CZYLI STARANIA O UZYSKANIE DOKTORATU NA WYDZIALE PRAWA NA UNIWERSYTECIE W INGOLSZTADZIE (BAWARIA) W 1644 ROKU
Authors: Niczyporuk Piotr 
Published: August 2023

W dniu 11 lipca 1644 r. Aron Aleksander Olizarowski otrzymał na Uniwersytecie w Ingolsztadzie doktorat w zakresie prawa. Na Wszechnicy Ingolsztadzkiej studiowało w latach 1473-1700 co najmniej 828 studentów z Rzeczypospolitej Obojga Narodów, a jedynie 383 z nich wybrało konkretny kierunek studiów. Na Wydziale Prawa Uniwersytetu w Ingolsztadzie naukę pobierało co najmniej 110 polskich studentów, choć w rzeczywistości mogło studiować około 300 osób.
Aron Aleksander Olizarowski był jednym z kilku przedstawicieli Rzeczypospolitej Obojga Narodów, którzy zdobyli stopień doktora obojga praw: cywilnego (rzymskiego) i kanonicznego (utriusque iuris) na Wszechnicy Ingolsztadzkiej. Z reguły o stopnie naukowe ubiegali się przede wszystkim ci, którzy planowali dalszą karierę akademicką, a także dostojnicy państwowi i kościelni. Bez wątpienia Aron Aleksander Olizarowski wraz ze swym przyjacielem Szymonem Dilgerem, po otrzymaniu na Uniwersytecie w Ingolsztadzie doktoratu w zakresie prawa, zostali profesorami Akademii Wileńskiej. Również baron Fryderyk Aleksander Kotulynski oraz Tomas Hornaeus mogli z dużym prawdopodobieństwem piastować urzędy w Rzeczypospolitej Obojga Narodów.. Wymogi związane z uzyskaniem tego stopnia doktora obojga praw na Wydziale Prawa Uniwersytetu w Ingolsztadzie były wysokie, ale nie odbiegały od tych stosowanych na innych europejskich uniwersytetach. Kandydat musiał mieć odpowiedni poziom wykształcenia, dokonać wpisu do albumu studentów oraz zdać stosowny egzamin. Wobec powyższego dziwić może okoliczność, że tylko kilku absolwentów z Rzeczypospolitej Obojga Narodów zwieńczyło swe studia w zakresie prawa doktoratem.
Stem Cell-based Therapies in Cardiovascular Diseases: From Pathophysiology
to Clinical Outcomes
Authors: Papastamos Charalampos , Antonopoulos Alexios S. , Simantiris Spyridon , Koumallos Nikolaos , Theofilis Panagiotis , Sagris Marios , Tsioufis Konstantinos , Androulakis Emmanuel , Tousoulis Dimitris 
Published: August 2023

Abstract:
Over 20 years of intensified research in the field of stem cells brought about unprecedented possibilities
in treating heart diseases. The investigators were initially fascinated by the idea of regenerating the lost myocardium
and replacing it with new functional cardiomyocytes, but this was extremely challenging. However,
the multifactorial effects of stem cell-based therapies beyond mere cardiomyocyte generation, caused by
paracrine signaling, would open up new possibilities in treating cardiovascular diseases. To date, there is a
strong body of evidence that the anti-inflammatory, anti-apoptotic, and immunomodulatory effects of stem cell
therapy may alleviate atherosclerosis progression. In the present review, our objective is to provide a brief
overview of the stem cell-based therapeutic options. We aim to delineate the pathophysiological mechanisms of
their beneficial effects in cardiovascular diseases especially in coronary artery disease and to highlight some
conclusions from important clinical studies in the field of regenerative medicine in cardiovascular diseases and
how we could further move onwards.
An improved synthesis of Karahanaenone
Authors: Espinoza-Hicks José C. , Zaragoza-Galán Gerardo , Camacho-Dávila Alejandro A. 
Published: August 2023

Abstract:
An improved synthesis of the monoterpene cyclic ketone karahanaenone, an ingredient in
cosmetics, perfumery, and pest-control agents, is reported. The synthesis uses linalyl acetate as the
starting material, which is converted to the epoxide with m-CPBA and submitted to an anhydrous lithium
perchlorate catalyzed rearrangement to the corresponding ketone. Hydrolysis and thermolysis of
the ketone afford karahanaenone in good yield. The catalyst can be recycled by simple dehydration
and reused without affecting the yield for the rearrangement.
3D Printing – A Revolution in Modern Healthcare: Recent Achievements
& Challenges
Authors: Chaudhary Anshul , Sharma Samiksha , Thakkar Arti R. 
Published: August 2023

Abstract:
The pharmaceutical industry grows every year keeping public health as a priority, protection,
and economic development. The industry is mostly concentrated on the novel drug development
process as well as new methods that can help improve the recovery rate of a condition and improve the
quality of patient treatment. Pharmaceutical companies have recently experimented with producing
medications using 3D printing to increase their quality and improve user health. Later, in 2015, the
companies found success by producing the 3D-printed medication Spritam, which had already received
US FDA approval. Over the past few years, the medical device industry has adapted to 3D
printing technology and creative companies have used it to produce goods with distinctive content,
appearance, and customizability. However, these distinctive capabilities of 3D printing have brought
forth new legal difficulties and troubling issues with the regulatory agencies' acceptance of these devices.
Customizability and distinctive construction procedures of medical devices printed via 3D printing
techniques have difficulties in attaining quality assurance and regulatory criteria for manufacturing.
Advancement in 3D printing technology has helped in the production of various innovative medical
products along with new structures and constituents. The present review discusses distinctive regulatory
problems faced by the USFDA as well as by other regulatory authorities in the case of approval
of 3D printing products and measures required to develop regulations for the safety, quality, and effectiveness
of 3D printing Devices.
Industrial Production and Therapeutic Application of Botulinum
Neurotoxin: The Role of C. botulinum Type A
Authors: Kadir S. Danish 
Published: August 2023

Abstract:
Botulinum neurotoxin has remarkably transitioned from a food safety hazard and biological
warfare to an effective therapeutic drug. Currently, botulinum neurotoxins have seven serotypes
(BoNT/A-G) in the form of protein complexes produced by Clostridium, a gram-positive and sporeforming
bacteria. The conversion of toxins into useful drug substances of choice using the biotechnological
process is tremendously increasing. Recent studies have shown that Botulinum neurotoxin-A
(BoNT/A) has different biological activities and potencies in experimental and clinical conditions. They
also indicate that the manufacturing process influences the potency and efficacy of BoNT/A drugs.
Thus, this review focuses on the following criteria: detailed Fed-batch operation that includes the upstream
and downstream processing of BoNT/A, the underlying mechanism behind the neurotoxic effect,
and commercially available FDA-approved BoNT/A products and their therapeutic uses. Still, some research
gaps exist in the mechanism for the treatment of psychiatric disorders.
A Deep Learning Model to Detect Fake News about COVID-19
Authors: Shanmugavel Selva Birunda , Devi Rangaswamy Kanniga , Muthukannan Muthiah 
Published: August 2023

Aims/Background::
Twitter has rapidly become a go-to source for current events coverage. The more people rely on it, the more important it is to provide accurate data. Twitter makes it easy to spread misinformation, which can have a significant impact on how people feel, especially if false information spreads around COVID-19.

Methodology:
Unfortunately, twitter was also used to spread myths and misinformation about the illness and its preventative immunization. So, it is crucial to identify false information before its spread gets out of hand. In this research, we look into the efficacy of several different types of deep neural networks in automatically classifying and identifying fake news content posted on social media platforms in relation to the COVID-19 pandemic. These networks include long short-term memory (LSTM), bi-directional LSTM, convolutional-neural-networks (CNN), and a hybrid of CNN-LSTM networks.

Results:
The "COVID-19 Fake News" dataset includes 42,280, actual and fake news cases for the COVID-19 pandemic and associated vaccines and has been used to train and test these deep neural networks.

Conclusion:
The proposed models are executed and compared to other deep neural networks, the CNN model was found to have the highest accuracy at 95.6%.
The Effect of Leadership, Motivation and Job Satisfaction on Employee Performance and Compensation as Moderation Variables
Authors: Ofar Moh , Mursidi Mursidi , Rumijati Aniek 
Published: August 2023

This study aims to examine the influence of leadership, motivation and job satisfaction on employee performance and compensation as a moderation variable of the study on CV. Citiplan in Malang. The sampling technique uses a saturated sampling technique, with all employee of CV. Citiplan which is 47 respondents. The analytical tool used is a moderated regression analysis using SPSS. The instrument in this study is the validity test of the reliability test, the test of classical assumptions. Hypothesis using the T test and uji F using SPSS. The results showed that leadership has a significant influence on employee performance, motivation has a significant influence on employee performance, job satisfaction has a significant influence on employee performance. Leadership, motivation, job satisfaction has a positive and significant influence on employee performance. Compensation moderates on the influence of leadership, motivation, work integrity on employee performance.
Percepción y satisfacción de estudiantes de Enfermería con la educación virtual en época de COVID-19
Authors: Canova-Barrios Carlos Jesús , Méndez Patricia Graciela , Sosa Liliana Rosa , Flores Marcela Anahí , Rodríguez Mónica Andrea , Hernández Silvina Soledad 
Published: August 2023

Objetivo: Analizar la percepción y la satisfacción con la educación en modalidad virtual de los estudiantes de la carrera de Licenciatura en Enfermería de una institución de educación superior de carácter público de la Ciudad Autónoma de Buenos Aires, Argentina, durante el segundo semestre de 2021. Metodología: Estudio analítico, transversal y cuantitativo. La muestra estuvo compuesta por 121 estudiantes, seleccionados mediante muestreo no probabilístico, quienes respondieron un instrumento conformado por 24 preguntas. Resultados: Los encuestados fueron mayormente de sexo femenino (84.30 %), con media de edad de 29.2 años (DE: 8), de tercer año (55.37 %) y con hijos (44.63 %). Respecto a la percepción sobre la modalidad virtual se halló que las clases fueron consideradas como motivantes para el aprendizaje (66.94 %), los alumnos pudieron mantener la atención entre un 75-99 % del tiempo durante la clase (38.84 %), una baja cantidad pudo realizar todas las consultas al docente (16.52 %) y la mayoría sintió nerviosismo ante la evaluación remota al mismo nivel que su contraparte presencial (52.89 %). La satisfacción global con la modalidad fue puntuada con una media de 6.9 sobre 10 y el 75.20 % los encuestados desea continuar con clases virtuales. Conclusiones: La satisfacción fue caracterizada como media. Las variables que se relacionaron con una mayor satisfacción con la educación remota son la tenencia de hijos, la mayor edad, la creencia de que se hubiese aprendido más con clases presenciales, el tiempo que perciben que pueden mantener la atención en clases virtuales, la baja sensación de nerviosismo ante la evaluación virtual y la ausencia de dificultades para la conexión a las clases sincrónicas.
Balanced Scorecard Internal Process Perspective: Applying Data Analytics to Monitor Police Department Performance
Authors: Janvrin Diane J. , Mascha Maureen Francis , Burney Laurie 
Published: August 2023

ABSTRACT
Employers expect graduates to perform data analytics using both organizational and publicly available data. Interestingly, few teaching cases provide students with needed exposure to data analytics in managerial or governmental accounting. In this case, students assume the role of a managerial accountant employed at Municipal Consulting, LLC. Students assist the Police Commissioner in using a Balanced Scorecard approach to analyze how her department responds to crime patterns and to develop next year’s budget. This case requires students to critique, analyze, and evaluate Internal Business Process Perspective Balanced Scorecard measures supported by publicly available data using data visualization software. The case includes instructions for both Tableau and Power BI. The case covers three skills: (1) extract, transform, and load data; (2) develop data visualization software experience; and (3) analyze data. The case is designed for senior level undergraduate and graduate courses in managerial, data analytics, and governmental accounting.
Applying Use Case 2.0 Approach to The Development of IoT-Based Rainfall Monitoring System
Authors: Fajar Mohammad , Chandra Ferian Bagus , Arfandy Hamdan 
Published: August 2023

The use of Internet of Things (IoT) technology for monitoring and controlling environmental conditions or objects is quite popular. However, most of the development of the IoT systems including rainfall monitoring systems, mainly focuses on the implementation perspective, rather than discussing the development approaches or design techniques. The use of suitable development approaches will increase maintainability aspect of the IoT system in the future. Therefore, the aim of this study is to implement and evaluate the use case 2.0 approach in modeling and designing an IoT-based monitoring rainfall system. Data collection was performed through evaluation using object-oriented metrics to measure encapsulation, polymorphism, and reusability properties of the designed system. In modeling the IoT system, collected requirements specifications are organized into user stories. The user stories are then mapped into UML use case diagrams. Each of the use case should be sliced into thinner pieces, taking into account of the basic and alternative flows of the user stories. Moreover, the use case slices are designed, implemented, and evaluated independently. The results of modeling and designing a rainfall monitoring system using the use-case 2.0 are then implemented on the NodeMCU platform and Android-based application. Evaluation results show that the implementation of use-case Reading, Viewing and Searching for Rainfall Data can be run successfully on the target platform. The measurement uses object-oriented metrics on the designed IoT system indicating that the use case slices have an impact on the ease of system modification level.