bluuebunny/crossref_metadata_2025_split huggingface dataset:
Structural insights into MIC2 recognition by MIC2-associated protein in Toxoplasma gondii
Authors: Zhang Su , Wang Fangfang , Zhang Dujuan , Liu Dongsheng , Ding Wei , Springer Timothy A. , Song Gaojie 
Published: August 2023

AbstractMicroneme protein 2 (MIC2) and MIC2-associated protein (M2AP) play crucial roles in the gliding motility and host cell invasion of Toxoplasma gondii. Complex formation between MIC2 and M2AP is required for maturation and transport from the microneme to the parasite surface. Previous studies showed that M2AP associates with the 6th TSR domain of MIC2 (TSR6), but the detailed interaction remains unclear. In this study, we report crystal structures of M2AP alone and in complex with TSR6. TSR domains have an unusually thin, long structure with a layer of intercalated residues on one side. The non-layered side of TSR6 with hotspot residue His-620 at the center binds to M2AP. Remarkably, we show that TSR6 residue Y602 is dynamic; it equilibrates between being part of the layer (the layered state) and in a flipped-out state in the absence of M2AP. However, when bound to M2AP, Y602 shifts to the flipped-out state. Our findings provide insights into the association and stabilization of MIC2-M2AP complex, and may be used to develop new therapies to prevent infections caused by this parasite.
A two-step workflow based on plasma p-tau217 to screen for amyloid β positivity with further confirmatory testing only in uncertain cases
Authors: Brum Wagner S. , Cullen Nicholas C. , Janelidze Shorena , Ashton Nicholas J. , Zimmer Eduardo R. , Therriault Joseph , Benedet Andrea L. , Rahmouni Nesrine , Tissot Cécile , Stevenson Jenna , Servaes Stijn , Triana-Baltzer Gallen , Kolb Hartmuth C. , Palmqvist Sebastian , Stomrud Erik , Rosa-Neto Pedro , Blennow Kaj , Hansson Oskar 
Published: August 2023

AbstractCost-effective strategies for identifying amyloid-β (Aβ) positivity in patients with cognitive impairment are urgently needed with recent approvals of anti-Aβ immunotherapies for Alzheimer’s disease (AD). Blood biomarkers can accurately detect AD pathology, but it is unclear whether their incorporation into a full diagnostic workflow can reduce the number of confirmatory cerebrospinal fluid (CSF) or positron emission tomography (PET) tests needed while accurately classifying patients. We evaluated a two-step workflow for determining Aβ-PET status in patients with mild cognitive impairment (MCI) from two independent memory clinic-based cohorts (n = 348). A blood-based model including plasma tau protein 217 (p-tau217), age and APOE ε4 status was developed in BioFINDER-1 (area under the curve (AUC) = 89.3%) and validated in BioFINDER-2 (AUC = 94.3%). In step 1, the blood-based model was used to stratify the patients into low, intermediate or high risk of Aβ-PET positivity. In step 2, we assumed referral only of intermediate-risk patients to CSF Aβ42/Aβ40 testing, whereas step 1 alone determined Aβ-status for low- and high-risk groups. Depending on whether lenient, moderate or stringent thresholds were used in step 1, the two-step workflow overall accuracy for detecting Aβ-PET status was 88.2%, 90.5% and 92.0%, respectively, while reducing the number of necessary CSF tests by 85.9%, 72.7% and 61.2%, respectively. In secondary analyses, an adapted version of the BioFINDER-1 model led to successful validation of the two-step workflow with a different plasma p-tau217 immunoassay in patients with cognitive impairment from the TRIAD cohort (n = 84). In conclusion, using a plasma p-tau217-based model for risk stratification of patients with MCI can substantially reduce the need for confirmatory testing while accurately classifying patients, offering a cost-effective strategy to detect AD in memory clinic settings.
Src tyrosine kinase promotes cardiac remodeling induced by chronic sympathetic activation
Authors: Li Wenqi , Zhu Yuzhong , Wang Wenjing , He Dan , Feng Lei , Li Zijian 
Published: August 2023

Abstract
Cardiac remodeling serves as the underlying pathological basis for numerous cardiovascular diseases and represents a pivotal stage for intervention. The excessive activation of β-adrenergic receptors (β-ARs) assumes a crucial role in cardiac remodeling. Nonetheless, the underlying molecular mechanisms governing β-AR-induced cardiac remodeling remain largely unresolved. In the present study, we identified Src tyrosine kinase as a key player in the cardiac remodeling triggered by excessive β-AR activation. Our findings demonstrated that Src mediates isoproterenol (ISO)-induced cardiac hypertrophy, fibrosis, and inflammation in vivo. Furthermore, Src facilitates β-AR-mediated proliferation and transdifferentiation of cardiac fibroblasts, and hypertrophy and cardiomyocytes in vitro. Subsequent investigations have substantiated that Src mediates β-AR induced the extracellular signal-regulated protein kinase (ERK1/2) signaling pathway activated by β-AR. Our research presents compelling evidence that Src promotes β-AR-induced cardiac remodeling in both in vivo and in vitro settings. It establishes the promoting effect of the β-AR/Src/ERK signaling pathway on overall cardiac remodeling in cardiac fibroblasts and underscores the potential of Src as a therapeutic target for cardiac remodeling.
A Narrative Approach to Synthesizing Research on Vietnamese Bilingual and Monolingual Children
Authors: Pham Giang T. 
Published: August 2023

Purpose:
This review article offers a narrativized synthesis of my research over the past 15+ years with Vietnamese-speaking children based on data collected from individual bilingual and monolingual children in preschool and elementary schools.

Method:
I begin with a positionality narrative to describe who I am in relation to the research conducted. I provide an overview of the research program including tool building and how my research with bilinguals in the United States led me to international collaborations in Vietnam.

Results:

I present main findings from this body of work in three areas: typical bilingual development, reading performance in Vietnam, and characteristics of developmental language disorder in the Vietnamese language. Implications within each area are discussed in terms of clinical application and future research directions. Practitioners and researchers alike can freely access the Vietnamese assessment tools created and validated to date from our website,
https://vietslp.sdsu.edu/
.

Conclusions:
This research overview aims to offer clinicians and researchers the sociocultural context for understanding the relevance of this body of research. It also serves as an invitation for new generations of scholars, particularly scholars of color, to see their own unique positionings and perspectives as valuable and necessary for scientific innovation and progress.

Presentation Video:

https://doi.org/10.23641/asha.23929491
The Influence of Sensorineural Hearing Loss on the Relationship Between the Perception of Speech in Noise and Dysarthric Speech
Authors: Yoho Sarah E. , Barrett Tyson S. , Borrie Stephanie A. 
Published: August 2023

Purpose:
The ability to understand speech under adverse listening conditions is highly variable across listeners. Despite this, studies have found that listeners with normal hearing display consistency in their ability to perceive speech across different types of degraded speech, suggesting that, for at least these listeners, global skills may be involved in navigating the ambiguity in speech signals. However, there are substantial differences in the perceptual challenges faced by listeners with normal and impaired hearing. This study examines whether listeners with sensorineural hearing loss demonstrate the same type of consistency as normal-hearing listeners when processing neurotypical (i.e., control) speech that has been degraded by external noise and speech that is neurologically degraded such as dysarthria.

Method:

Listeners with normal hearing (
n
= 31) and listeners with sensorineural hearing loss (
n
= 36) completed an intelligibility task with neurotypical speech in noise and with dysarthric speech in quiet.

Results:
Findings were consistent with previous work demonstrating a relationship between the ability to perceive neurotypical speech in noise and dysarthric speech for listeners with normal hearing, albeit at a higher intelligibility level than previously observed. This relationship was also observed for listeners with hearing loss, although listeners with more severe hearing losses performed better with dysarthric speech than with neurotypical speech in noise.

Conclusions:
This study demonstrated a high level of consistency in intelligibility performance for listeners across two different types of degraded speech, even when those listeners were further challenged by the presence of sensorineural hearing loss. Clinical implications for both listeners with hearing loss and their communication partners with dysarthria are discussed.
A Prospective Study of the Effect and Safety of Atorvastatin on the Recurrence of Chronic Subdural Hematoma after Burr Hole Surgery
Authors: Bumpetch Duangkamol , Sitthinamsuwan Bunpot , Nunta-aree Sarun 
Published: August 2023

Abstract
Introduction Chronic subdural hematoma (CSDH) is a common neurosurgical condition. Recent studies showed efficacy of atorvastatin in reducing the requirement of surgical treatment. This study aimed to evaluate the efficacy and safety of atorvastatin in reducing the recurrence of CSDH after burr hole surgery.
Methods This prospective study included patients with CSDH who underwent burr hole surgery. Atorvastatin at 20 mg per day was administered to all patients for 4 weeks postoperatively. The major outcome was the recurrence rate of CSDH at 8 weeks following the operation.
Results Seventy-three patients who completed the 4-week course of atorvastatin were included. The mean age was 73.9 years. The most common cause of CSDH was falling. The mean hematoma volume was 106.3 mL. There was no adverse effect of atorvastatin in all of 73 patients. During the 8-week postoperative period, recurrent CSDH was found in 2 of 73 (2.7%) patients. In a comparison of the recurrence rate of CSDH between patients with use of atorvastatin from the present and previous studies (2.6–4.8%), and patients without use of atorvastatin from previous studies (9.8–19%), a marked reduction in recurrent CSDH after burr hole surgery was found in patients with use of atorvastatin.
Conclusion An administration of atorvastatin of 20 mg daily for 4 weeks following burr hole surgery is safe and may be helpful in reducing the recurrence rate of CSDH after burr hole surgery.
The impact of sports participation on individuals’ subjective well-being: the mediating role of class identity and health
Authors: Liu Ningning , Zhong Qikang 
Published: August 2023

AbstractAlthough studies have explored the relationship between physical activity and subjective well-being, exploration of the mechanisms underlying the effects of sports participation on subjective well-being remains limited. In the context of promoting the deep integration of national fitness and national health in China, we explore the patterns and differences in the effects of sports participation on the subjective well-being of different populations and explore the underlying mechanisms of the effects of sports participation on individual subjective well-being based on body and society theory. Using data from the China General Social Survey, this study used multiple linear regression models, propensity score matching methods, quantile regression and chain mediation models to explore the relationship between sport participation and subjective well-being, and further elaborated the mediating role of subjective class identity and health in it. The results of the study showed that sports participation significantly and positively affected individual subjective well-being. The results of quantile regression and heterogeneity tests showed that the effect of sports participation on individual subjective well-being showed a significant quantile effect and group heterogeneity. Sports participation had a more significant effect on the well-being of older adults. The results of the mediation effect test showed that sports participation increased subjective well-being by enhancing individuals’ subjective class identity and health, respectively, while subjective class identity and health had a significant chain mediation effect. Based on the findings of the study this paper provides some practical suggestions for improving the subjective well-being of residents, especially the elderly, which will provide some valuable references for the next studies on residents’ well-being and life satisfaction.
A long trend of sexually transmitted diseases before and after the COVID-19 pandemic in China (2010–21)
Authors: Xu Aifang , Zuo Zhongbao , Yang Chunli , Ye Fei , Wang Miaochan , Wu Jing , Tao Chengjing , Xun Yunhao , Li Zhaoyi , Liu Shourong , Huang Jinsong 
Published: August 2023

Background The longer ongoing benefits of coronavirus disease 2019 (COVID-19) non-pharmaceutical interventions (NPIs) for sexually transmitted diseases (STDs) in China are still unclear. We aimed to explore the changes in five STDs (AIDS, hepatitis B, hepatitis C, gonorrhoea, and syphilis) before, during, and after the COVID-19 pandemic in mainland China, from 2010 to 2021. Methods The number of the monthly reported cases of the five STDs were extracted from the website to construct the Joinpoint regression and autoregressive integrated moving average (ARIMA) models. Eight indicators reflecting NPIs were chosen from the COVID-19 Government Response Tracker system. The STDs and eight indicators were used to establish the Multivariable generalised linear model (GLM) to calculate the incidence rate ratios (IRRs). Results With the exception of hepatitis B, the other four STDs (AIDS, hepatitis C, gonorrhoea, and syphilis) had a positive average annual percent change over the past 12 years. All the ARIMA models had passed the Ljung–Box test, and the predicted data fit well with the data from 2010 to 2019. All five STDs were significantly reduced in 2020 compared with 2019, with significant estimated IRRs ranging from 0.88 to 0.92. In the GLM, using data for the years 2020 (February–December) and 2021, the IRRs were not significant after adjusting for the eight indicators in multivariate analysis. Conclusion Our study demonstrated that the incidence of the five STDs decreased rapidly during the COVID-19 pandemic in 2020. A recovery of STDs in 2021 was found to occur compared with that in 2020, but the rising trend disappeared after adjusting for the NPIs. Our study demonstrated that NPIs have an effect on STDs, but the relaxation of NPI usage might lead to a resurgence.
A comprehensive survey on the cold metal transfer process for additive manufacturing
Authors: Shanker Hari , Wattal Reeta 
Published: August 2023

Abstract
Cold metal transfer (CMT) welding has shown significant interest in the research community because of its excellent capabilities. A low heat input associated with the CMT process has made this technology important for difficult-to-weld stuff like aluminum and its alloys and dissimilar material joining. Nowadays, the primary emphasis has been on avoiding the negative impact of joining in order to achieve a longer service life. The aim of this analysis is to recognize the process parameters that affect additive manufacturing in terms of material and process by using CMT and its variants. It is observed that CMT as an advanced welding approach has gained a significant attraction of researchers in investigating it for additive manufacturing which leads to the advancement of a renowned wire and arc additive manufacturing, abbreviately called (WAAM) process. Bead width, height, current, and voltage are the main parameters that are influenced by linear energy density and in turn, leads to the quality of the fabricated products.
Magnetic anisotropy in the ferromagnetic Mn and N doped ZnO Nanocrystals
Authors: Agarwal Manish Baboo , Ali Shahjad , Mehrotra Manu , Panday Manish Kumar , Gupta Neeraj , Agarwal Seema 
Published: August 2023

Abstract
(Mn, N)- codoped ZnO thin films were prepared by two step process. Study of Magnetic anisotropy in Mn and N codoped ZnO nanoparticles was studied. X-ray diffraction (XRD) &X-ray photoelectron spectroscopy (XPS) reveals that Manganese (Mn) and Nitrogen (N) ions in ZnO lattice exists as Mn2+ and N3-. Hysteresis measurement shows that at room temperature the samples show ferromagnetic nature and also indicate that the samples are having magnetic anisotropic behavior. This ferromagnetic nature in the samples is because of the hybridization between 2p of N & 3d of Mn state. The compound formed, corresponds to Mn-N-Mn cluster, which is found to be energetically strong enough for ferromagnetism at room temp.
Potential Assessment of Solar and Wind in Himachal Pradesh, India
Authors: Laledia Saurabh Singh , Channi Harpreet Kaur 
Published: August 2023

Abstract
India is second in population with 1.3 billion people in 2022. A large population means a huge electricity consumption. Renewable energy—hydropower, solar, wind, etc.—supplies 37% of India’s power requirement in 2021. Coal, crude oil, nuclear power, natural gases, and others make up the rest. Due to continued exploitation of conventional resources, we have had to develop and convert to renewable energy alternatives. Solar and wind power are among the easiest and cheapest green energy sources. Thus, we must promote eco-friendly energy production to reduce pollution and greenhouse gases. In Khajjiar, Himachal Pradesh, solar panels and wind turbines may provide green energy. Based on the results of the optimization, the best solution is to use parts with an NPC of $41,338. Table 9 shows that the proposed system needs 7 kW of PV panels, a 1.9 kW converter, and a 10 kW battery. The levelized COE of the proposed system is $0.65, and the OC is $1047.
Sustainability Performance Evaluation of Solar Panels Using Multi Criteria Decision Making Techniques
Authors: Manoj Vasupalli , Pilla Ramana , Pudi Vasudeva Naidu 
Published: August 2023

Abstract
Researchers from all around the world had worked tirelessly to find ways to lower the cost of solar panels, create more efficient new goods, boost their fuel efficiency, and create innovations and largely dependent on photovoltaic system technology. When compared to other forms of non-conventional energy, such as wind and tidal, solar has been one of the most widely employed resources. To harness the power of the sun using photovoltaics, one needs a photovoltaic system. Research into improving the cost-effectiveness of solar panels, which play a crucial part in photovoltaic systems, is a global endeavour. The process of choosing solar panels is nuanced, encompassing a wide range of subjective and objective considerations. To choose the best solar cell for a PV array, we use the VIKOR (VIekriterijumsko KOmpromisno Rangiranje) and TOPSIS (Technique for Order of Preference by Similarity to Ideal Solution) techniques. Using the Analytical Hierarchy Process (AHP) and a resemblance to ideal result ordering technique, the study’s goals were satisfied. VIKOR and other MCDM tools like the AHP and TOPSIS are used to rank candidates in terms of performance. An in-depth case study was conducted using six different kinds of solar panels to show how well the approaches work.
Modelling and Simulation of Thermostatically Controlled Loads for Power System Regulation in Building-to-Grid Integration Framework
Authors: Pal Kalyan , Harish VSKV 
Published: August 2023

Abstract
Since last few decades the inclusion of renewable energies in the grid power system is rapidly increasing with the increase in technologies to minimize the use of conventional fossil fuels for minimizing the emission of greenhouse gases. But the uncertain behaviour of the renewable energy sources lead to a challenge of maintaining the stability and reliability of the grid system and to optimize the supply and demand balance. It is identified that more than 40% energy consumption is made by the consumers of buildings. To minimize the power fluctuation, caused by inclusion of renewable systems, the thermostatically controlled loads (TCLs) like ACs, refrigerators, heaters of buildings can be considered as flexible loads for regulation purpose as TCLs share the major part of the total power consumption and also TCLs can be adjusted without compromising the comfort level. In this paper, a practical linear network model of the multi layered construction materials of building is developed with 3R2C electrical circuit model and corresponding state-space equations are formulated, and also a 2ndorder TCL model is proposed as an RC network equivalent where main focus is on the works, which develop specific control strategies by modelling the building energy systems.
SRF theory-based shunt active power filter for power quality improvement in grid-interfaced solar photovoltaic system
Authors: Prasad Dinanath , Kumar Narendra , Sharma Rakhi 
Published: August 2023

Abstract
This paper uses Shunt Active Power Filter (SAPF) in a polluted and unbalanced mains voltage for the compensation of current harmonics along with the reactive power. During compensation the reference current is calculated by the theory of Synchronous Reference Frame (SRF). This study utilizes the Photovoltaic (PV) energy, a renewable energy source, for which a maximum power point tracking (MPPT) method, an incremental conductance (InCnd), is employed. To modify the energy storage of dc-voltage, an artificial neural network controller (ANN) is used. The power system toolbox of MATLAB/SIMULINK is used to simulate the system being proposed. The SAPF is compared and assessed on the basis of PI control, FUZZY controller, and Artificial Neural Network (ANN). The results demonstrate the ANN control’s efficiency in optimizing the DC capacitor energy storage, sinusoidal form of the current, and reactive power compensation. A low Total Harmonic Distortion (THD) will be achieved with the proposed system which shows the efficacy of the method presented.
Cooperative Spectrum Sensing with Amplify and Forward Scheme in CRNs
Authors: Sharma Krishnakant , Awasthi Meenakshi 
Published: August 2023

AbstractRecent research has identified cognitive radio (CR) as a possible solution for increasing spectrum usage by allowing secondary access to unlicensed bands. Having no interference with the primary system is a need for this secondary access. Due to this requirement, spectrum sensing becomes a crucial component of cognitive radio systems. The ease and effectiveness of energy detection make it an appealing technique among popular spectrum sensing techniques. The uses of the available radio network spectrum, finite and important resources, have been severely constrained by the rising demand for wireless applications. It is essential to develop a successful cooperative spectrum sensing (CSS) system for cognitive radio (CR), whose are seen to be a promising solution for improving spectrum usage. A clusters-based optimal selective CSS system is suggested in this paper to shorten reporting times for the bandwidth whiles preserving a given performance by the sensing mode. The clusters have a dynamic head in each selected cluster in accordance with data sensing qualities for CR users in the cognitive radio. Clusters have been arranged based on identifying the major signals to the noise ratio value. Making a decision to use cluster sensing is based on a chosen CSS threshold that minimizes the likelihood of sensing inaccuracy. It takes less time to make the report for the decision of the clusters’ fusion centre is significantly reduced by the Amplify and Forward-based CSS approach that is proposed. The optimal Chair-Varshney rule is applied to the fusion centre for achieving a high sensing performance is depending on the information that is currently available about the cluster. Based on the results availability of simulation, it is clear to propose a way to supersede the other existing methods.