bluuebunny/crossref_metadata_2025_split huggingface dataset:
ANALYSIS OF VERTICAL MOVEMENTS ON FREEDOM AND BULLET MOVEMENT EVENTS USING VIDEO TRACKING METHOD
Authors: Kanga Lusia Koja , Astro Richardo Barry , Ika Yasinta Embu 
Published: May 2023

Analysis of vertical motion in free fall and bullet motion with the video tracking method has been carried out. This study aims to analyze the vertical motion pattern in the free fall and bullet motion, specifically the ball launching from the edge of the table. The research was carried out by rolling the ball until it slid and releasing the ball from the edge of the table until it experienced a free fall motion with the height of the table from the two activities of about 1 meter. This activity was carried out repeatedly until obtaining 5 videos of each event and recorded using the Vivo android camera. Furthermore, researchers analyzed using the Tracker application to obtain information data about vertical motion patterns, graphs of changes in position with time, and graphs of velocity against time. Result regressive analysis can derive equations Vy = Ax + B and Y = Ax + B
HUBUNGAN LINGKUNGAN BELAJAR DENGAN HASIL BELAJAR IPA FISIKA KELAS VIII SMPK INEMETE NANGAPANDA
Authors: Seku Agustina Yunita , Harso Aloisius , Daud Maimunah H. 
Published: May 2023

Penelitian ini bertujuan untuk mengetahui ada tidaknya hubungan yang signifikan antara lingkungan belajar dengan hasil belajar IPA pada siswa kelas VIII SMPK Inemete Nangapanda Kabupaten Ende tahun pelajaran 2020/2021. Jenis penelitian ini adalah penelitian korelasional. Populasi penelitian ini adalah siswa kelas VIII SMPK Inemete Nangapanda tahun pelajaran 2020/2021 dan sampel penelitian berjumlah 45 siswa yang diperoleh dengan teknik sampling jenuh. Data yang diperoleh dari sampel berupa angket lingkungan belajar dan dokumentasi hasil belajar. Data dianalisis menggunakan kerelasi product moment. Hasil penelitian menunjukan bahwa terdapat hubungan yang signifikan antara lingkugan belajar dengan hasil belajar IPA Fisika. Hal ini dibuktikan melalui perhitungan uji korelasi product moment yaitu 0,002 < 0,05 atau nilai probability < nilai signifikan sehingga dapat disimpulkan bahwa terdapat korelasi antar variabel lingkungan belajar dengan hasil belajar IPA Fisika.
Catatan Editor: Menavigasi Tantangan dan Menciptakan Peluang, Peran Vital Ilmu Psikologi di Era Kecerdasan Buatan
Authors: Gumelar Gumgum 
Published: May 2023

Catatan editor kali ini mencoba untuk melihat perspektif umum dari peran kecerdasan buatan atau artificial intelligence (AI) dalam ilmu psikologi dan dampaknya terhadap kesehatan mental manusia. Penulis menunjukkan bahwa teknologi AI dapat memengaruhi berbagai aspek perilaku dan kesehatan mental manusia, seperti gangguan tidur, ketergantungan pada teknologi, dan masalah kesehatan mental lainnya. Selain itu, teknologi AI juga dapat memengaruhi pengambilan keputusan manusia dalam berbagai bidang, seperti pada perekrutan karyawan atau penegakan hukum.
Salah satu studi di jurnal Cyberpsychology, Behavior, and Social Networking menunjukkan bahwa ketergantungan pada internet dan teknologi dapat menyebabkan gangguan perilaku, seperti obsesi dengan internet, rasa cemas saat tidak menggunakan perangkat digital, dan kehilangan kontrol atas penggunaan teknologi. Studi yang ada menunjukkan bahwa semakin sering seseorang menggunakan teknologi, semakin besar kemungkinan mereka mengalami masalah kesehatan mental. Oleh karena itu, psikologi harus memahami dampak dari perkembangan teknologi AI terhadap kesehatan mental dan perilaku manusia. Psikologi dapat memainkan peran penting dalam mengatasi tantangan yang dihadapi oleh teknologi AI, seperti mengembangkan strategi untuk mengurangi ketergantungan pada teknologi dan mendorong penggunaan teknologi AI yang bertanggung jawab. Artikel ini diharapkan dapat memberikan pemahaman yang lebih baik tentang peran AI dalam ilmu psikologi dan memotivasi para peneliti untuk melakukan penelitian lebih lanjut tentang dampak teknologi AI terhadap kesehatan mental manusia.
Opportunities and Challenges of Using FinTech in Takaful Financial Services
Authors: Faqih Rijalul , Nurhayati Nurhayati 
Published: May 2023

Fintech is currently part of the development of takaful, the results of research and studies related to this problem are still very limited, on the other hand all financial services industries are starting to shift to fintech, including the Islamic financial services industry. So it is necessary to explore the potential use of fintech in the sharia insurance industry, especially in terms of opportunities and challenges in the future. In particular, big data analytics and robo-advisory are explored and how takaful operators can combine them for better customer experience and gathering competitive intelligence. To stay competitive in a rapidly changing business environment, takaful operators need to identify and adopt fintechs that can positively impact customer experience and optimize cost efficiency.
The Effects of Extracted Peptide from Skin of Iraqi Frog (Rana ridibunda) on Human Leukemic Lymphocytes
Authors: Al-Khafaji Ali Jabbar Oleiwi 
Published: May 2023

The purified frog skin peptides were tested on leukemic patients lymphocytes, which revealed effects of cytotoxicity. Four frogs (Rana ridibunda) were stimulated by single intra-peritoneal injection of norepinephrine-HCl . Five different peptides;1(18) A, 2(19) L, 3(20) I,4(21) E and 5(22) Y were isolated and quantified. The peptide 3(20)I had 5.87% of hemolysis, while healthy human lymphocytes cytotoxic activity was for 2(19)L with inhibition( -10.4%).All peptides were subjected to polyacrylamide gel electrophoresis. The results revealed peptides 1(18)A, 2(19)L, 3(20)I which appeared as low as 10 KDa marker. Theoretically, the whole polypeptide had a molecular weight 7488.61 Dalton and contained on 62.405 amino acid (a.a). The peptide 4(21)E had a highest inhibitory effect(46%) on tumor cell line L20B. Furthermore , peptides effects on acute and chronic myeloid lymphocytic leukemia patients cell cultures revealed peptides selectivity in their action according to their net charge and functional group as reactant proton donor by the evidence of peptide 5(22)Y, 16.22 Dalton so it was either N—terminus (--NH2) or C—terminus (--OH) that led to cross cell membrane then acted as antigen mediated and activated cells in a high significant value (-142.37± 47.69)for acute myeloid lymphocytic leukemia .Both of peptides 3(20) I and 2(19) L were revealed a highly significant differences within Chr.40 and Chr. 22 of inhibition effects by testing volumes 15 µl and 10 µl . Those inhibition effects were due to peptides reaction with mitochondrial membrane which led to apoptosis . Conclusion; Frog skin peptides have a therapeutically worth for malignant diseases. Also some of peptides were activated lymphocytes may to cure immunodeficiency.
A Preliminary Study for Solving the Gap Problems in Protein Sequence Alignment
Authors: El-Lakkani Ali , El-Sherif Seham 
Published: May 2023

Abstract
Protein sequence alignment has many applications in molecular biology. The existing algorithms produce imperfect alignments, because of two factors: 1) the proposed gap penalty function and its parameter values 2) the gap problems. The present work is an attempt to obtain correct alignments using a novel alignment method based on the harmonic identical words present in the sequences to be aligned. To prove the accuracy of this approach, our method is applied to three pairs of sequences. The results are compared with the corresponding results obtained from three alignment programs; the EMBL-EBI EMBOSS Needle program with minimum number of gaps, the MSAEMBL-EBI MUSCLE and Clustal Omega programs. The comparison shows that, in case of highly similar protein sequences the identity and the maximum score value of our alignment method is higher than that of the EMBL-EBI EMBOSS Needle, MUSCLE and Clustal Omega programs. In case of distantly related sequences, the maximum score value of our alignment is much higher than that of the EMBL-EBI EMBOSS Needle, MUSCLE and Clustal Omega programs and the obtained percent identity is shifted from the twilight zone to the safe zone.Our results also show that the gap lengths distribution follows a power law, and this is not achieved by many current alignment programs.
Fire-resistant bio-based polyurethane foams designed with two by-products derived from sugarcane fermentation process
Authors: Capêto Ana Paula , Amorim Manuela , Sousa Sérgio , Costa Joana R. , Uribe Braian , Guimarães Ana Sofia , Pintado Manuela , Oliveira Ana L. S. 
Published: May 2023

Abstract
There is a great interest in replacing conventional fossil-based polymers and composites with inorganic or organic waste-based materials and filler-type additives, to promote environmental sustainability and circularity. The main objective of this study was the design of water-blown polyurethane rigid foams integrating two by-products derived from the Amyris fermentation process of production of β-farnesene. The distillation residue (FDR) was used as main polyol component in the neat formulation of the foams (PF) that it was supplemented (PFA) with 4.5% of sugarcane bagasse ash (SCBA) added as a filler with fire-retardant properties. The impact of both by-products on the foam density and morphology, and in the thermal, mechanical, and flame-retardant properties was assessed. SCBA presence led to a reduction in apparent density, cells size, and glass transition, delaying the thermal decomposition. The differences observed in the thermal conductivity and flammability test parameters suggest a visible impact of the ash incorporation, thus meeting the fire protection standard UL 94, class HB.
Highlighting the need for further optimization, this work presents a practical example of the integration of different wastes derived from the same fermentation process in the formulation of sustainable PUR foams with reduced flammability.
Characterization of UV sex chromosomes and synteny-guided phylogenomic resolution of subgenomes in Bryopsida mosses
Authors: Gao Bei , Li Xiaoshuang , Liang Yuqing , Zhang Jianhua , Oliver Melvin , Zhang Daoyuan 
Published: May 2023

Abstract
The UV chromosomal sex-determination system primarily found in bryophytes, together with the XY and ZW chromosomal sex-determination systems, constitute the three principal types of chromosomal sex determination systems in nature. In this report, the genome of the moss Bryum argenteum was sequenced and assembled into 11 chromosomes containing 17,721 protein coding genes. A giant female U sex chromosome demonstrated conspicuously lower gene density, higher repeat coverage, and higher GC content compared to the ten autosomes. By further characterizing the sex-chromosomes and sex-linked genes in seven chromosomal-scale Bryopsida genomes, lower gene densities and distinct GC contents were revealed to be common in all moss sex chromosomes, likely resulting from degeneration. Weaker purifying selection, as evidenced by lower codon usage preference in sex-linked genes, was shared in most but not all Bryopsida mosses. Retained genomic syntenies between U/V sex chromosomes and ancestral Bryopsida chromosome 4 provided new evidence to support an autosomal origin for sex chromosomes. The seven ancestral Bryopsida chromosomes were reconstructed to decipher and depict chromosomal evolution; Dicranidae and Bryidae mosses demonstrated one and three chromosomal fusions and evolved 13 and 11 ancestral chromosomes, respectively. Ancient whole genome duplications characterized many plant lineages including the psi polyploidy event that occurred in the early diversification of Bryopsida. By aligning the modern chromosomes to the seven reconstructed ancestral chromosomes, genomic synteny-guided phylogenomic analyses provided strong evidence for the ancestral psi event shared by Dicranidae, Bryidae and P. patens. Furthermore, ancestral chromosomal projections and a phylogenomic resolution of Bryopsida subgenomes revealed distinct and lineage-specific chromosomal loss patterns in Dicranidae and Bryidae following the psi event. Our reconstructions reinforced the evolutionary significance and phylogenetic timing of the psi event and provided systemic insights into the sex and chromosomal evolution in mosses.
Atypical Presentation of a Right Atrial Myxoma: A Case Report
Authors: Molina Guarina , Contreras Rafael , Alvarez Melissa , Goodman Jason , Yekta Arshad 
Published: May 2023

Abstract
BACKGROUND
Primary cardiac tumors are rare, with a reported incidence of approximately 0.02% and atrial myxomas account for approximately 15-20% of the cases. Most of these are located in the left atrium and unusually involve the right side of the heart.
CASE PRESENTATION
We present a case of a 52-year-old man who presented with chest pain, initially presumed to be acute coronary syndrome, and found to have a right atrial tumor of 6.3 cm, with a hospital course complicated by neurologic symptoms. Definite treatment included surgical removal. Pathology analysis of the mass confirmed the histology of myxoma.
CONCLUSIONS
Differential diagnoses for atrial myxomas include thrombus and other tumors such as rhabdomyomas. Clinical manifestations include fatigue, peripheral edema, ascites, and diastolic murmur similar to tricuspid stenosis. More than half of these tumors rise in the left atrium and may be complicated by neurologic symptoms secondary to embolization. Right atrial myxomas are rare and described in the literature with a myriad of symptoms, while in some cases, asymptomatic. Given the low incidence and variety in clinical picture, careful documentation of these cases is suggested for early prevention and guideline of management.
Design and Modelling the Compressive Strength of High-Performance Concrete with Silica Fume: A Soft Computing Approach
Authors: Adebanjo Abiola , Shafiq Nasir , Razak Siti Nooriza Abd , Kumar Vicky , Ahmad Farhan Syed , Singh Priyanka , Abubakar Adamu Sanni 
Published: May 2023

Abstract
Soft computing methods were used in this research to design and model the compressive strength of high-performance concrete (HPC) with silica fume. Box-Behnken design-based response surface methodology (RSM) was used to develop 29 HPC mixes with a target compressive strength of 80 ± 10 MPa. Cement (450–500 kg/m3), aggregates (1500–1700 kg/m3), silica fume (SF) (20–45% weight of cement) and water-binder (w/b) ratio of (0.24–0.32) were provided as input factors while the compressive strength at 7 and 28 days were analysed as responses. Datasets for the artificial neural network (ANN) prediction were generated from 87 experimental observations from the compressive strength test. Performance indicators such as p-value, coefficient of determination (R2), and mean square error (MSE) were used to assess the models. Results demonstrated that RSM worked relatively well in projecting compressive strength with model p-values < 0.05 and R2 values of 0.913 and 0.892 for compressive strength at 7 and 28 days, respectively. In addition, RSM performed better in detecting the synergistic effects of the variables on the responses. On the other hand, ANN best generalised the relationship between independent and dependent variables considering the low MSE of 12.32 and 14.60, and high R2 values of 0.912 and 0.946 for compressive strength at 7 and 28 days, respectively. Model equations were developed to predict the compressive strength of silica-based HPC after 7 and 28 days. It is considered that adopting components from both approaches could help the design process for developing consistent mixes of HPC with supplementary cementitious materials (SCMs).
An Effective Straightforward Protocol for the Treatment of Graves’ Hyperthyroidism for Primary Care Providers
Authors: Eugenio Felisha , Raza Syed M. Kazim , Hasan Ishmum , Moldovan Christina , Zopey Mohan , Davidson Mayer B. , Friedman Theodore 
Published: May 2023

Abstract
Background – The prevalence of hyperthyroidism is very common in the United States (approximately 1.2%) with Graves’ Disease (GD) being the most common non-iatrogenic cause. The limited number of endocrinologists and their concentration in larger cities means that primary care providers (PCPs) must treat a large number of these patients. This paper provides an effective, straightforward protocol for them to do so.Material & Methods – Patients with GD hyperthyroidism were referred to a county endocrinology clinic by PCPs in clinics that cared for medically underserved, mostly minority patients, a challenging population to treat. Hyperthyroidism was diagnosed by elevated free T4 and/or free T4 concentrations, euthyroidism by normal concentrations of both and hypothyroidism by low free T4 or elevated TSH concentrations. Patients were treated with methimazole with initial doses and up-titration based on free T4 and free T3 concentrations and down-titration by free T4 and TSH concentrations.Results – At the initial visit, 155 patients were, and 54 patients were not, respectively, taking an anti-thyroid drug. At the initial visit, patients either remained on methimazole, were started on the drug or were switched to it from propylthiouracil. The 209 patients were followed for up to 18 months. The protocol rapidly reversed the hyperthyroidism in most patients and at the end of the study, 72% were euthyroid, 19% were hyperthyroid and 9% were hypothyroid. Medication non-adherence probably accounted for those who were hyperthyroid at that time.Conclusion – PCPs following this protocol will enable them to effectively treat patients with GD hyperthyroidism.
The effect of work-family conflict on fertility intentions: evidence from China
Authors: Shi XiaoJuan , Mo FuRong 
Published: May 2023

Abstract
We constructed two indicators to measure work-family conflict, work-home conflict and work-family responsibility. Data from the 2019 China Integrated Social Conditions Survey Project are also used to causally estimate the effect of work-family conflict on fertility intentions. Our findings suggest that work-home conflict promotes population fertility intentions, while work-family responsibility conflict has a dampening effect on fertility intentions. The effect of work-family conflict on fertility intentions was heterogeneous in terms of gender, household registration, and educational attainment. Based on the study findings, we believe that the Chinese government should promote the population's willingness to have children in three ways: encouraging couples to share household chores, sharing family responsibilities, and shortening the number of years of education.
Elevated Serum Uric Acid in norovirus-associated Benign Convulsions with Mild Gastroenteritis in Children
Authors: Jiang Daoju , Shi Kaili , Li Suyun , Liu Guangming , Liu Zheng , Shen Jun , Li Peiqing 
Published: May 2023

Abstract
Background Recent studies have shown that serum uric acid levels are associated with gastroenteritis-associated benign seizures (CWG), but the diagnosis of CWG is an exclusive diagnosis. This study explored the clinical characteristics of norovirus-associated CWG to provide evidence for reducing unnecessary tests.Methods Medical records of children admitted to the Department of Emergency of Guangzhou Women and Children′s Medical Center with Stool etiology was positive for norovirus between January 2019 and January 2020 were divided into CWG group and simple gastroenteritis group ,and were reviewed and analyzed.Results A total of 89 norovirus cases were enrolled. Age of onset, male/female ratio of CWG group and simple gastroenteritis group were 49 cases, mean 20.84 ± 5.83 months and 27:22, 40 cases, mean 19.00 ± 13.48 months and, 26:14, respectively.Serum uric acid levels in CwG and simple gastroenteritis groups increased in 43 (87.8%) and 9 (22.5%) cases, respectively. The average serum uric acid level in the CwG group was significantly higher than that in the simple gastroenteritis group (564.36 ± 125.28umol/L vs 338.42 ± 141.03umol/L [mean ± standard deviation], p < 0.0001) .The potential of hydrogen(PH), bicarbonate༈HCO3–), BE bases excess༈BE༉ of CWG group were also lower than those of simple gastroenteritis group, the differences were statistically significant.Conclusion Norovirus-associated CWG should be considered in children with norovirus-associated gastroenteritis and recurrent seizures, significantly increased serum uric acid and acidosis. Lumbar puncture and cranial imaging may not be recommended.
Deciphering the Immune Landscape of Head and Neck Squamous Cell Carcinoma: A Single-Cell Transcriptomic Analysis of Regulatory T Cell Responses to PD-1 Blockade Therapy
Authors: Feriz Adib Miraki , Bahraini Fatemeh , Khosrojerdi Arezou , Azarkar Setareh , Sajjadi Seyed Mehdi , Lotfollahi Mohammad , HosseiniGol Edris , Honardoost Mohammad Amin , Saghafi Samira , Silvestris Nicola , Leone Patrizia , Safarpour Hossein , Racanelli Vito 
Published: May 2023

Abstract
Immunotherapy is changing the Head and Neck Squamous Cell Carcinoma (HNSCC) landscape and improving outcomes for patients with recurrent or metastatic HNSCC. A deeper understanding of the tumor microenvironment (TME) is required in light of the limitations of patients' responses to immunotherapy. Here, we aimed to examine how Nivolumab affects infiltrating Tregs in the HNSCC TME. We used single-cell RNA sequencing data from eight tissues isolated from four HNSCC donors before and after Nivolumab treatment. Interestingly, the study found that Treg counts and suppressive activity increased following Nivolumab therapy. We also discovered that changes in the CD44-SSP1 axis, NKG2C/D-HLA-E axis, and KRAS signaling may have contributed to the increase in Treg numbers. Furthermore, our study suggests that decreasing the activity of the KRAS and Notch signaling pathways, and increasing FOXP3, CTLA-4, LAG-3, and GZMA expression, may be mechanisms that enhance the killing and suppressive capacity of Tregs. Additionally, the result of pseudo-temporal analysis of the HNSCC TME indicated that after Nivolumab therapy, the expression of certain inhibitory immune checkpoints including TIGIT, ENTPD1, and CD276 and LY9, were decreased in Tregs, while LAG-3 showed an increased expression level. The study also found that Tregs had a dense communication network with cluster two, and that certain ligand-receptor pairs, including SPP1/CD44, HLA-E/KLRC2, HLA-E/KLRK1, ANXA1/FPR3, and CXCL9/FCGR2A, had notable changes after the therapy. These changes in gene expression and cell interactions may have implications for the role of Tregs in the TME and in response to Nivolumab therapy.
Efficient dispersion of organic fluorophores by size matching with a new di-functionalized spacer interleaved into layered double hydoxide
Authors: ZERBIB Guillaume , BOYER Damien , CHADEYRON Geneviève , REVERET François , LEROUX Fabrice 
Published: May 2023

Abstract
Strongly luminescent when diluted in aqueous solution, Sulforhodamine B (SRB) is an organic fluorescent molecule suffering from aggregation caused quenching (ACQ) in its solid state. Its co-intercalation in very small quantities (0.12 mol%) in a layered double hydroxide (LDH) matrix with phenylenedipropionate (PPA) anions, a di-functionalized new spacer matching its size, is found to be highly effective, with more than 99% of the SRB molecules uptaken. The resulting hybrid material enables luminescence with an absolute quantum yield (PLQYabs) reaching 39% under UV excitation and even reaching 60% at its maximum. The dispersion of the luminescent hybrid powder constituted of SRB molecules intercalated into LDH platelets in silicone results in homogeneous composite films with loading as high as 40 wt.% useable as masterbatch. The optical properties are found to remain after thermal treatment up to 120°C with a decrease in PLQYabs of 5% only, making it a good candidate for the development of rare-earth-free phosphors.