bluuebunny/crossref_metadata_2025_split huggingface dataset:
The German Revised version of the Niigata PPPD Questionnaire (NPQ-R): Development with patient interviews and an expert Delphi consensus
Authors: Behrendt Frank , Stark Michaela , Chételat Sarah , Schädler Stefan , Trost Wiebke , Parmar Katrin , Gerth Hans Ulrich , Bonati Leo H. , Schuster-Amft Corina 
Published: September 2023

Background
Persistent postural-perceptual dizziness (PPPD) is a functional disorder of the nervous system and currently one of the most common types of chronic dizziness. Currently existing questionnaires do not fully assess patients’ specific symptoms of PPPD. The Japanese Niigata PPPD Questionnaire (NPQ) was recently developed following consensus-based diagnosis criteria. The aim of this study was to translate it into German, evaluate its content with the help of experts and patients and, if necessary, revise the original version to allow for a comprehensive assessment of patients’ PPPD-related symptoms.

Methods
A 3-round expert Delphi survey and semi-structured patient interviews were conducted. 28 experts from Switzerland, Germany and Austria working in hospitals or outpatient centres were asked to complete a first questionnaire on various aspects of PPPD, on the translated, original NPQ and their own related experiences (Round one), a second questionnaire with statements regarding PPPD they could agree or disagree with using a 6-point Likert-scale (Round two), and a third survey to finally reach a consensus on statements to be integrated into the NPQ. In addition, eleven patients (mean age of 64.6±12.6 years; 6 females) were selected according to the criteria for the diagnosis of PPPD proposed by the Bárány Society and participated in a semi-structured interview asking for their opinion on the content of the original NPQ. All collected data were analysed using a descriptive evaluation and a qualitative content analysis based on verbatim transcripts.

Results
Seven new items were added to the NPQ based on expert and patient comments and ratings. Its revised version (NPQ-R) comprises 19 items divided into five subscales using a 7-point Likert-scale with two additional subscales relating to associated symptoms and symptom behaviour in PPPD. The new maximal score is 114 points compared to 72 for the NPQ.

Conclusion
The NPQ-R is the first patient-reported outcome measurement for patients with PPPD in German. It should help to provide a comprehensive assessment of the intensity of PPPD in affected patients.
Facilitators and barriers in implementation of active TB drug safety monitoring and management (aDSM) in programmatic management of drug resistance TB in Dar es Salaam region
Authors: Nyaulingo Belinda Chriacus , Mhimbira Francis Apolinary 
Published: September 2023

Background
World Health Organization (WHO) recommends that active TB Dug Safety Monitoring and Management (aDSM) be adopted in countries’ programmatic management of DR-TB services. In Tanzania, the National TB Leprosy Programme (NTLP), under the ministry of health, adopted the aDSM component in 2018. The study evaluated the facilitators and barriers of aDSM implementation in Dar es Salaam.

Materials and methods
This was a process evaluation study that adapted the descriptive cross-sectional approach, conducted in Dar es Salaam region. A total of 19 respondents, including clinicians, DOT (Direct Observed Therapy) nurses and key NTLP personnel, were interviewed using interview guides. Qualitative content analysis based on Graneheim & Lundman was used to guide the analysis.

Results
For aDSM to be implemented in a health facility, tools like forms for recoding and reporting, access to a functional laboratory for carrying out the required monitoring tests are a necessity. Moreover, the NTLP monitors the implementation through received aDSM reports and DR-TB supportive supervisions. However, it was found that in many health facilities, aDSM was partially being implemented due to various barriers: inadequate trained staff for aDSM implementation, administrative burden in reporting and delaying in AE management.

Conclusion
aDSM is inadequately being implemented due to the many setbacks faced by HCWs. aDSM-specific supportive supervisions and trainings to HCWs; incorporating the current manual aDSM reporting flow into the already existing electronic (Tanzania Medicine and Medical Drugs Authority) TMDA database seems useful.
Ocular findings in patients with acquired ATTRv amyloidosis following domino liver transplantation
Authors: Kitahara Junya , Yoshinaga Tsuneaki , Kakihara Shinji , Hirano Takao , Imai Akira , Miyahara Teruyoshi , Yazaki Masahide , Sekijima Yoshiki , Murata Toshinori 
Published: September 2023

Purpose
To investigate the presence of amyloidosis-related ocular findings in patients who received domino liver transplantation from ATTRv amyloidosis donors.

Methods
We reviewed the ocular findings in patients who had previously undergone domino liver transplantation and received ophthalmologic examinations between January 2009 and March 2023. The presence of amyloidosis-related ocular findings was retrospectively assessed by two ophthalmologists.

Results
During the study period, a total of 7 patients with 14 eyes were examined. All patients were considered as acquired ATTRv amyloidosis. The mean age at the final visit was 64.6±8.4 years (52–75 years), and the mean time since domino liver transplantation was 167.6±76.2 months (69–257 months). The two evaluators’ assessments for amyloidosis-related ocular findings were completely identical. No amyloid fibril deposition was observed in the pupil, lens, or vitreous. Five patients (10 eyes) had a Schirmer test result of 5mm or less than 5 mm, and four patients with a total of 8 eyes underwent fluorescein angiography and indocyanine green angiography, and no evidence of retinal amyloid angiopathy was found on fluorescein angiography. However, three patients with 6 eyes showed choroidal amyloid angiopathy on indocyanine green angiography.

Conclusion
While cases of choroidal amyloid angiopathy were observed, serious amyloidosis-related ocular complications such as vitreous opacity or secondary glaucoma did not occur even in the long term after domino liver transplantation.
Curriculum for Justice and Harmony: Deliberation, Knowledge, and Action in Social and Civic Education, Keith C. Barton and Li-Ching Ho (2022)
Authors: Dang Jing , Chia Yeow-Tong 
Published: September 2023

Review of: Curriculum for Justice and Harmony: Deliberation, Knowledge, and Action in Social and Civic Education, Keith C. Barton and Li-Ching Ho (2022)
Abingdon and New York: Routledge, 228 pp.,
ISBN 978-1-00301010-4, e-book, £35.09
ISBN 978-0-36744-503-4, p/bk, £38.99
Older Adult-Onset of Inflammatory Bowel Diseases Is Associated With Higher Utilization of Analgesics: A Nationwide Cohort Study
Authors: Dalal Rahul S. , Nørgård Bente Mertz , Zegers Floor D. , Kjeldsen Jens , Friedman Sonia , Allegretti Jessica R. , Lund Ken 
Published: September 2023

INTRODUCTION:
Patients with inflammatory bowel diseases (IBD) commonly require analgesic medications to treat pain, which may be associated with complications. We examined trends of analgesic use according to age at IBD onset.

METHODS:
This nationwide cohort study included adults diagnosed with IBD between 1996 and 2021 in Denmark. Patients were stratified according to their age at IBD onset: 18–39 years (young adult), 40–59 years (adult), and older than 60 years (older adult). We examined the proportion of patients who received prescriptions for analgesic medications within 1 year after IBD diagnosis: strong opioids, tramadol, codeine, nonsteroidal anti-inflammatory drugs, and paracetamol. Multivariable logistic regression analysis was performed to examine the association between age at IBD onset and strong opioid prescriptions and the composite of strong opioid/tramadol/codeine prescriptions.

RESULTS:
We identified 54,216 adults with IBD. Among them, 25,184 (46.5%) were young adults, 16,106 (29.7%) were adults, and 12,926 (23.8%) were older adults at IBD onset. Older adults most commonly received analgesic prescriptions of every class. Between 1996 and 2021, strong opioid, tramadol, and codeine prescriptions were stable, while paracetamol prescriptions increased and nonsteroidal anti-inflammatory drug prescriptions decreased. After multivariable logistic regression analysis, older adults had higher adjusted odds of receiving strong opioid prescriptions (adjusted odds ratio 1.95, 95% confidence interval 1.77–2.15) and the composite of strong opioid/tramadol/codeine prescriptions (adjusted odds ratio 1.93, 95% confidence interval 1.81–2.06) within 1 year after IBD diagnosis compared with adults.

DISCUSSION:
In this nationwide cohort, older adults most commonly received analgesic prescriptions within 1 year after IBD diagnosis. Additional research is needed to examine the etiology and sequelae of increased analgesic prescribing to this demographic.
Faktor Gejala dan Komorbid yang Berhubungan dengan Kematian Pasien COVID-19 di Tangerang Selatan, November 2020-Mei 2021
Authors: Harahap Ade Ayu Lanniari , Helda Helda 
Published: September 2023

Background : Coronavirus disease 2019 (COVID-19) is an infectious disease caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). The number of confirmed cases and deaths of COVID-19 continues to increase globally. Epidemiology and clinical characteristics of COVID-19 cases from Indonesia are scanty. High-quality evidence to understand the disease and can be used as a basis for policymaking. Therefore, this study was conducted to determine the symptom factors and comorbidities associated with mortality in COVID-19 patients in South Tangerang from November 2020 to May 2021.Methode : A Case-control study of confirmed cases of COVID-19 in South Tangerang. The cases included 337 COVID-19 patients who died and 347 controls who were still alive. Data on age, gender, symptoms, and comorbidities were collected through Epidemiological Surveillance (ES) of COVID-19 patients at the South Tangerang Health Office from November 2020 to May 2021 in association with death and analyzed using chi-square test and simple logistic regression.Result : The results of multivariate analysis showed that risk factors such as age (OR=5.059; 95% CI: 3.209-7.974), gender (OR=2.650; 95% CI: 1.758-3.996), fever symptoms (OR=0.499; 0.331- 0.753), co-morbidities with diabetes mellitus (OR=15.94; 95% CI: 7.397-34.350), hypertension (OR=4.005; 95% CI: 2.440-6.572), heart disease (OR=7.249; 95% CI: 2.893-18.162 ) and chronic kidney failure (OR=12,523, 95% CI: 1,571-99,808) had an influence on the incidence of death of COVID-19 positive patients in South Tangerang.Conclusion : These findings indicate that older age, male gender, symptoms of fever, and comorbidities include a history of diabetes mellitus, hypertension, heart disease, and kidney failure due to the death of COVID-19 patients in South Tangerang. The need to enhance specific public health measures to reduce the risk of death in patients infected with COVID-19.
Pemanfaatan Limbah Serbuk Kayu dan Fly-Ash Sebagai Bahan Tambah Pembuatan Genteng Beton Eco-Friendly
Authors: Faqrudin Ahcmad Faruk , Setiawan Syaiful Kharis , Susanti Riza , Widodo Puji 
Published: September 2023

Atap di indonesia sebagian masih memakai genteng beton dikarenakan mahal dan berat. Indonesia juga merupakan negara penghasil kayu dan batu bara terbanyak di dunia, hal tersebut yang akan menyebabkan adanya limbah serbuk kayu dan fly ash. Oleh karena itu,dilakukan penelitian yang bertujuan memanfaatkan limbah serbuk kayu dan limbah fly-ash sebagai bahan campuran dan mencoba membuat genteng beton yang lebih ringan. Sehingga dalam penggunaanya bisa meringankan konstruksi atap dan juga memanfaatkan limbah sehingga genteng beton menjadi lebih ekonomis namun mempunyai kualitas yang memenuhi SNI. Metode yang digunakan adalah metode eksperimental, dengan komposisi campuran semen dan pasir yaitu 1 : 3 dan menggunakan 4 variasi benda uji yaitu untuk serbuk kayu variasi A, 0%; B, 25%; C, 0%; D, 25% dari berat pasir sedangkan untuk fly ash variasi A, 0%; B, 0%; C, 25%; D, 25% dari berat semen. Pengujian ini meliputi sifat tampak, ukuran, kerataan, beban lentur, penyerapan serta rembesan air. Hasil beban lentur rata-rata pada variasi A = 170,632 kg, B = 168,933 kg, C = 195,446 kg, D = 179,812 kg. Untuk hasil pengujian penyerapan air rata-rata pada variasi A = 9,44%, B = 10,07%, C = 6,12%, D = 8,13%. Penggunaan serbuk kayu dapat menurunkan kuat lentur dan meningkatkan penyerapan air dan penambahan fly ash akan meningkatkan kuat lentur dan menurunkan penyerapan air dibandingkan genteng beton normal. Maka dari itu bisa disimpulkan bahwa genteng beton dengan penambahan serbuk kayu dan fly ash lebih baik, ekonomis dan ringan daripada genteng beton tanpa bahan tambah serta masih memenuhi SNI.
Krypton: Real-Time Serving and Analytical SQL Engine at ByteDance
Authors: Chen Jianjun , Shi Rui , Chen Heng , Zhang Li , Li Ruidong , Ding Wei , Fan Liya , Wang Hao , Xiong Mu , Chen Yuxiang , Dong Benchao , Guo Kuankuan , Lin Yuanjin , Liu Xiao , Shi Haiyang , Wang Peipei , Wang Zikang , Yang Yemeng , Zhao Junda , Zhou Dongyan , Zuo Zhikai , Liang Yuming 
Published: September 2023

In recent years, at ByteDance, we have started seeing more and more business scenarios that require performing real-time data serving besides complex Ad Hoc analysis over large amounts of freshly imported data. The serving workload requires performing complex queries over massive newly added data items with minimal delay. These systems are often used in mission-critical scenarios, whereas traditional OLAP systems cannot handle such use cases. To work around the problem, ByteDance products often have to use multiple systems together in production, forcing the same data to be ETLed into multiple systems, causing data consistency problems, wasting resources, and increasing learning and maintenance costs.
To solve the above problem, we built a single Hybrid Serving and Analytical Processing (HSAP) system to handle both workload types. HSAP is still in its early stage, and very few systems are yet on the market. This paper demonstrates how to build Krypton, a competitive cloud-native HSAP system that provides both excellent elasticity and query performance by utilizing many previously known query processing techniques, a hierarchical cache with persistent memory, and a native columnar storage format. Krypton can support high data freshness, high data ingestion rates, and strong data consistency. We also discuss lessons and best practices we learned in developing and operating Krypton in production.
Towards General and Efficient Online Tuning for Spark
Authors: Li Yang , Jiang Huaijun , Shen Yu , Fang Yide , Yang Xiaofeng , Huang Danqing , Zhang Xinyi , Zhang Wentao , Zhang Ce , Chen Peng , Cui Bin 
Published: September 2023

The distributed data analytic system - Spark is a common choice for processing massive volumes of heterogeneous data, while it is challenging to tune its parameters to achieve high performance. Recent studies try to employ auto-tuning techniques to solve this problem but suffer from three issues: limited functionality, high overhead, and inefficient search.
In this paper, we present a general and efficient Spark tuning framework that can deal with the three issues simultaneously. First, we introduce a generalized tuning formulation, which can support multiple tuning goals and constraints conveniently, and a Bayesian optimization (BO) based solution to solve this generalized optimization problem. Second, to avoid high overhead from additional offline evaluations in existing methods, we propose to tune parameters along with the actual periodic executions of each job (i.e., online evaluations). To ensure safety during online job executions, we design a safe configuration acquisition method that models the safe region. Finally, three innovative techniques are leveraged to further accelerate the search process: adaptive sub-space generation, approximate gradient descent, and meta-learning method.
We have implemented this framework as an independent cloud service, and applied it to the data platform in Tencent. The empirical results on both public benchmarks and large-scale production tasks demonstrate its superiority in terms of practicality, generality, and efficiency. Notably, this service saves an average of 57.00% memory cost and 34.93% CPU cost on 25K in-production tasks within 20 iterations, respectively.
TPCx-AI - An Industry Standard Benchmark for Artificial Intelligence and Machine Learning Systems
Authors: Brücke Christoph , Härtling Philipp , Palacios Rodrigo D Escobar , Patel Hamesh , Rabl Tilmann 
Published: September 2023

Artificial intelligence (AI) and machine learning (ML) techniques have existed for years, but new hardware trends and advances in model training and inference have radically improved their performance. With an ever increasing amount of algorithms, systems, and hardware solutions, it is challenging to identify good deployments even for experts. Researchers and industry experts have observed this challenge and have created several benchmark suites for AI and ML applications and systems. While they are helpful in comparing several aspects of AI applications, none of the existing benchmarks measures end-to-end performance of ML deployments. Many have been rigorously developed in collaboration between academia and industry, but no existing benchmark is standardized.
In this paper, we introduce the TPC Express Benchmark for Artificial Intelligence (TPCx-AI), the first industry standard benchmark for end-to-end machine learning deployments. TPCx-AI is the first AI benchmark that represents the pipelines typically found in common ML and AI workloads. TPCx-AI provides a full software kit, which includes data generator, driver, and two full workload implementations, one based on Python libraries and one based on Apache Spark. We describe the complete benchmark and show benchmark results for various scale factors. TPCx-AI's core contributions are a novel unified data set covering structured and unstructured data; a fully scalable data generator that can generate realistic data from GB up to PB scale; and a diverse and representative workload using different data types and algorithms, covering a wide range of aspects of real ML workloads such as data integration, data processing, training, and inference.
Automatic SQL Error Mitigation in Oracle
Authors: Pasupuleti Krishna Kantikiran , Li Jiakun , Su Hong , Ziauddin Mohamed 
Published: September 2023

Despite best coding practices, software bugs are inevitable in a large codebase. In traditional databases, when errors occur during query processing, they disrupt user workflow until workarounds are found and applied. Manual identification of workarounds often relies on a trial-and-error method. The process is not only time-consuming but also requires domain expertise that users are often lacking. In this paper, we propose a framework to automatically mitigate errors that occur during query compilation (including optimization and code generation) without any user intervention. An error is intercepted by the database internally, a workaround is identified for it, and the query is recompiled using the workaround. The entire process remains transparent to the user with the query being executed seamlessly. The proposed technique handles SQL errors during query compilation and provides three types of mitigation strategies - i) quickly failover to one of the readily-available historical plans for the statement ii) apply targeted error-correcting directives (hints) identified from the optimizer context at the time of the error iii) modify the global configuration of the optimizer using hints.
This feature has been implemented and will be released in an upcoming version of Oracle Autonomous Database.
Research and optimization of tunnel construction scheme for super-large span high-speed railway tunnel in poor tuff strata
Authors: Ma Jianfei , He Shaohui , Liu Xiabing , He Jiaxin 
Published: September 2023

Abstract
The rapid traffic developments create demands for shallow four-line high-speed railway tunnels in weak soils, while construction technologies of such tunnels have yet to be reported. In this article, the construction schemes for a shallow four-line high-speed railway tunnel with a span of 26.3 m in weak tuff strata are investigated by numerical analysis and in-situ tests. First, 20 construction schemes of the shallow super-large span high-speed railway tunnel are proposed and simulated by the Finite Difference Method, including eight schemes for grade V rocks and 12 schemes for grades IV and III rocks. The mechanical response of grade V rock mass is simulated by the Bolt–Kelvin Mohr–Coulomb rheological model. The influence of construction method, rock grade, area, quantity, and excavation sequence of pilot tunnels on the rock deformation and the internal force of the primary support are comparatively explored. For further analysis, an 8 month field test was conducted to study the optimized effect of the construction scheme. Finally, a suggested construction method selection chart for super-large span tunnels in weak rocks (spans between 17 and 34 m) has been proposed. The research conclusion could provide a reference for building the super-large span tunnel in complex conditions.
Existence and multiplicity of solutions for a class of p-Kirchhoff-type equation R

N
Authors: Chen Lijuan , Xue Changfeng , Wang Fangfang 
Published: September 2023

Abstract
This article shows the existence and multiplicity of solutions for the following

p

p

-Kirchhoff-type equation:

a
+
b

∫

R

N

(

∣

∇

u
∣

p

+
V

(

x

)

∣
u
∣

p

)

d
x

(

−

△

p

u
+
V

(

x

)

∣
u
∣

p
−
2

u

)

=
λ
g

(

x

)

∣
u
∣

r
−
2

u
−
h

(

x

)

∣
u
∣

q
−
2

u
,

in

R

N

.

\left(a+b\mathop{\int }\limits_{{{\mathbb{R}}}^{N}}\left({| \nabla u| }^{p}+V\left(x){| u| }^{p}){\rm{d}}x\right)\left(-{\bigtriangleup }_{p}u+V\left(x){| u| }^{p-2}u)=\lambda g\left(x){| u| }^{r-2}u-h\left(x){| u| }^{q-2}u,\hspace{1.0em}\hspace{0.1em}\text{in}\hspace{0.1em}\hspace{0.33em}{{\mathbb{R}}}^{N}.

where

λ

\lambda

is a real parameter and

1
<
p
<
q
<
∞

1\lt p\lt q\lt \infty

,

a

a

and

b

b

are positive constants. Depending on the relationship of

p
,
q

p,q

, and

r

r

, we obtain the existence, multiplicity, and nonexistence of solutions to the abovementioned equation using variational methods.
Systemic observation and measurement of microgap formation in dental implant–abutment connection interface under fatigue
Authors: Mercan Cigdem , Gunay Bulutsuz Asli , Katiboglu Ahmet Bulent 
Published: September 2023

Abstract
Today, a variety of implant designs with different attachment types are widely used in dental implant systems to eliminate connection problems. However, there are still design issues that can significantly affect the long-term success of dental implants. One of these problems is the formation of a microgap in the abutment–implant interface, which can lead to abutment screw loosening, screw fracture, and abutment fracture under masticatory loading. In this in vitro study, the effects of gingival height, dental implant diameter, and abutment type (solid, digital, and ball) on microgap formation were observed after repetitive fatigue tests using an experimental design. After the tests, the optimal design factors were determined to minimize microgap formation. According to the results of the experimental design, the abutment type was found to be the most influential parameter on microgap formation. An implant diameter of 4.1 mm, the smallest gingival height of 0.5 mm, and a digital attachment combination were identified as the optimal design parameters based on the statistical approach (R
2 = 85.3 %).