bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of diabetes on recovery after radical gastrectomy for gastric cancer: A retrospective cohort study
Authors: Zhao Lei , Wei Lan , Fei Xiao-Lu 
Published: February 2025

BACKGROUND
Gastric cancer remains a significant global health concern. Radical gastrectomy is the primary curative treatment. Diabetes mellitus is a common comorbidity in patients undergoing surgery for gastric cancer, including radical gastrectomy. Previous studies have suggested that diabetes can negatively affect postoperative outcomes, such as wound healing, infection rates, and overall recovery. However, the specific impact of diabetes on recovery after radical gastrectomy for gastric cancer remains poorly understood. evaluate the influence of diabetes on postoperative recovery, including hospital stay duration, complications, and readmission rates, in patients undergoing gastrectomy for gastric cancer. Understanding these effects could help optimize perioperative management and improve patient outcomes.
AIM
To investigate the impact of diabetes on recovery after radical gastrectomy for gastric cancer and associated postoperative outcomes.
METHODS
This retrospective cohort study was performed at the Endocrinology Department of Xuanwu Hospital, Capital Medical University, Beijing, China. We examined patients who underwent radical gastrectomy for cancer between January 2010 and December 2020. The patients were divided into the diabetes and non-diabetes groups. The main outcomes included length of hospital stay, postoperative complications, and 30-day readmission rate. Secondary outcomes included quality of life indicators. Propensity score matching was used to adjust for potential confounding factors.
RESULTS
A total of 1210 patients were included in the study, with 302 diabetic patients and 908 non-diabetic patients. After propensity score matching, 280 patients were included in each group. Diabetic patients demonstrated significantly longer hospital stays (mean difference 2.3 days, 95%CI: 1.7-2.9, P < 0.001) and higher rates of postoperative complications (OR 1.68, 95%CI: 1.32-2.14, P < 0.001). The 30-day readmission rate was also higher in the diabetic group as compared to the non-diabetic group (12.5% vs 7.8%, P = 0.02).
CONCLUSION
Patients with diabetes mellitus undergoing radical gastrectomy for gastric cancer experience prolonged hospital stay, increased postoperative complications, and higher readmission rates, thus requiring optimized perioperative management strategies.
Retrospective analysis of delta hemoglobin and bleeding-related risk factors in pancreaticoduodenectomy
Authors: Lin Yi-Min , Yu Chao , Xian Guo-Zhe 
Published: February 2025

BACKGROUND
Objective and accurate assessment of blood loss during pancreaticoduodenectomy (PD) is crucial for ensuring the safety and efficacy of the procedure. While the visual method remains the most common clinical metric, many scholars argue that it significantly differs from actual blood loss and is inherently subjective.
AIM
To assess blood loss in PD via delta hemoglobin (ΔHb) and compare it with the visual method to predict bleeding-related risk factors.
METHODS
In this retrospective analysis, 1722 patients who underwent PD from 2017 to 2022 at Shandong Provincial Hospital were divided into three groups: Open PD (OPD), laparoscopic PD (LPD), and conversion to OPD (CTOPD). Intraoperative ΔHb (IΔHb) was calculated via preoperative and 72-hour-postoperative hemoglobin concentrations, and its association with visually obtained estimated blood loss (EBL) was analyzed. Perioperative ΔHb (PΔHb) was calculated via preoperative and predischarge hemoglobin concentrations. We compared the differences in IΔHb and PΔHb among the three groups, and performed univariate and multivariate regression analyses of IΔHb and PΔHb.
RESULTS
The preoperative general information of patients showed no statistically significant difference among the three groups (P > 0.05). The IΔHb in the OPD, LPD, and CTOPD groups were 22.00 (12.00, 36.00), 21.00 (10.00, 33.00), and 33.00 (18.12, 52.24) g/L, respectively; And the PΔHb in the OPD, LPD, and CTOPD groups were 25.87 (13.51, 42.00), 25.00 (14.00, 45.00), and 37.48 (21.64, 59.65) g/L, respectively, values significantly differed (P < 0.05). IΔHb and EBL were significantly correlated (r = 0.337, P < 0.001). The results of univariate and multivariate regression analyses indicated that American Society of Anesthesiologists (ASA) classification IV [95% confidence interval (CI): 2.330-37.811, P = 0.049] and preoperative total bilirubin > 200 μmol/L (95%CI: 2.805-8.673, P < 0.001) were independent risk factors for IΔHb (P < 0.05), and ASA classification IV (95%CI: 45.934-105.485, P < 0.001), body mass index > 24 kg/m2 (95%CI: 1.285-9.890, P = 0.011), and preoperative total bilirubin > 200 μmol/L (95%CI: 6.948-16.797, P < 0.001) were independent risk factors for PΔHb (P < 0.05).
CONCLUSION
There is a correlation between IΔHb and EBL in PD, so we can assess the patients’ intraoperative blood loss by the ΔHb method. ASA classification IV, body mass index > 24 kg/m², and preoperative total bilirubin > 200 μmol/L increased perioperative bleeding risk.
Laparoscopic microwave ablation for giant cavernous hemangioma coexistent with diffuse hepatic hemangiomatosis: Two case reports
Authors: Xu Fei , Kong Jian , Dong Shu-Ying , Xu Li , Wang Shao-Hong , Sun Wen-Bing , Gao Jun 
Published: February 2025

BACKGROUND
Hepatic hemangioma represents the most common benign primary hepatic neoplasm. Although most such tumors are small and asymptomatic, giant cavernous hemangioma (GCH) is frequently symptomatic, and needs intervention. Moreover, diffuse hepatic hemangiomatosis (DHH) is not rare in the liver parenchyma adjacent to a GCH. The management strategy for hepatic hemangiomas can differ depending on the presence of associated hemangiomatosis and the amount and distribution of the residual hepatic parenchyma.
CASE SUMMARY
Herein, we report two patients with GCH coexistent with DHH successfully treated by laparoscopic microwave ablation. The two GCHs were ablated completely and the ablated zone atrophied obviously in imaging follow-ups after ablation. Surprisingly, there was a trend toward gradual reduction and diminishment of DHH.
CONCLUSION
Thermal ablation treatment might be an effective and less invasive treatment for GCH coexistent with DHH around the hemangioma.
Predictive value of serum calcium ion level in patients with colorectal cancer: A retrospective cohort study
Authors: Shu Yin , Li Ke-Jin , Sulayman Subinur , Zhang Zi-Yi , Ababaike Saibihutula , Wang Kuan , Zeng Xiang-Yue , Chen Yi , Zhao Ze-Liang 
Published: February 2025

BACKGROUND
Serum calcium ion (Ca2+) is an economical and readily available indicator as a routine screening test for hospitalized patients. There are no studies related to serum Ca2+ level and digestive tract malignancy.
AIM
To evaluate the effectiveness of serum Ca2+ level in predicting the prognosis of patients with colorectal cancer (CRC).
METHODS
We retrospectively collected the data of 280 patients diagnosed with CRC who underwent radical surgery at the Affiliated Cancer Hospital of Xinjiang Medical University. By analyzing the clinicopathological features, differences between serum Ca2+ concentrations on the first day after surgery were determined. We used the receiver operating characteristic curve to assess the predictive ability of serum Ca2+ for survival. Survival analyses were performed using the Kaplan-Meier method, and multivariate Cox proportional risk regression was used to determine association between calibration serum Ca2+ levels and CRC survival outcomes.
RESULTS
By receiver operating characteristic curve analysis, the ideal threshold value for Ca2+ the first postoperative day and delta serum calcium (δCa2+) value were 1.975 and 0.245, respectively. Overall survival (OS) and progression-free survival (PFS) were better in both the high Ca2+ group and high δCa2+ group on the first postoperative day. The variables identified through univariate analysis were incorporated into multivariate analysis and showed that tumor differentiation (P = 0.047), T stage (P = 0.019), N stage (P < 0.001), nerve vascular invasion (P = 0.037), carcinoembryonic antigen (P = 0.039), baseline serum Ca2+ level (P = 0.011), and serum Ca2+ level on the first day (P = 0.006) were independent predictors of prognosis for patients undergoing feasible radical CRC surgery. Using the findings from the multifactorial analysis, we developed a nomogram and the calibration showed a good predictive ability.
CONCLUSION
Low serum Ca2+ level on the first postoperative day is an independent risk factor for OS and PFS in CRC.
Efficacy of fluorouracil combined with paclitaxel and oxaliplatin for the treatment of advanced gastric signet ring cell carcinoma
Authors: Liu Mi , Feng Bei , He Na , Yan Rong , Qin Jie 
Published: February 2025

BACKGROUND
Gastric signet ring cell carcinoma (GSRC) is a distinctive type of gastric cancer. It is a mucus-secreting adenocarcinoma that may progress to distant metastasis at an early stage. Because of poor differentiation, aggressive invasion, rapid progression, and other high-risk characteristics, early surgical intervention should be prioritized.
AIM
To explore the clinical efficacy of fluorouracil (5-FU) combined with paclitaxel and oxaliplatin for the treatment of advanced GSRC.
METHODS
A total of 85 patients with advanced GSRC were selected between January 2020 and June 2021 and randomly divided into a control group (n = 42, receiving standard chemotherapy) and a treatment group (n = 43, receiving monotherapy with oxaliplatin, 5-FU, and paclitaxel). Patients in the treatment group received a 135 mg/m2 infusion of paclitaxel for 3 hours, a 400 mg/m2 infusion of calcium folate (or 200 mg/m2 of levocalcium folate) for 2 hours, and an 85 mg/m2 infusion of oxaliplatin for 2 hours. This was followed by a continuous intravenous infusion of 2200-2400 mg/m2 5-FU for 46 hours using a portable pump.
RESULTS
The treatment group showed a median survival time of 11.7 months and an objective response rate (ORR) of 32.5%, significantly higher than the control group (P < 0.05). Serum carcinoembryonic antigen (CEA), carbohydrate antigen 19-9 (CA19-9), and albumin levels were correlated with treatment effectiveness in advanced GSRC (P < 0.01), but total serum protein was not correlated (P > 0.05). Safety and survival were assessed in all patients. Short-term efficacy was evaluated in 66 patients, with a disease control rate of 89.4% and an ORR of 48.5%. Median progression-free survival was 7.0 months (95% confidence interval [CI]: 6.85-7.15), and median overall survival was 10.6 months (95%CI: 9.86-11.3). Primary grade III/IV adverse events included neutropenia (22.1%) and peripheral neurotoxicity (10.3%).
CONCLUSION
This treatment regimen is more effective for patients with advanced GSRC. Serum levels of CEA, CA19-9, and albumin predicted chemotherapy efficacy, while total protein concentration correlated minimally and insignificantly.
Nonsurgical treatment of postoperative intestinal obstruction caused by heterotopic ossification of the mesentery: A case report
Authors: Chen Jing-Tian , Li Yao-Ping , Guo Shang-Qi , Huang Jin-Sheng , Wang Yong-Gang 
Published: February 2025

BACKGROUND
Among all forms of heterotopic ossification, heterotopic mesenteric ossification (HMO) is rare, with fewer than 100 reported cases to date. Postoperative early small bowel obstruction caused by HMO is even rarer, presenting extremely high surgical risks, the potential for multiple surgeries, and a poor prognosis. There have been no reported cases of conservative treatment for resolving such early postoperative obstruction.
CASE SUMMARY
A 57-year-old male presented with severe postoperative small bowel obstruction shortly after undergoing open radical resection for transverse colon cancer. Laparotomy revealed extensive adhesions in the proximal jejunum and mesentery, making it too difficult to relieve without injuring the small bowel. Additionally, multiple fixed nodules were found in the mesentery during the operation. Pathology confirmed the presence of heterotopic ossification. The patient was treated with methylprednisolone on postoperative day 1, which gradually relieved his symptoms.
CONCLUSION
Hormone therapy may have a potential role in treating small bowel obstruction caused by early HMO after operative intervention.
Imaging features and correlation with short-term prognosis in laparoscopic radical resection of colorectal cancer
Authors: Fang Ze-Hui , Hao Ai-Hua , Qi Yuan-Gang 
Published: February 2025

BACKGROUND
Colorectal cancer (CRC) is a malignant tumor with high morbidity and mortality rates worldwide. With the development of medical imaging technology, imaging features are playing an increasingly important role in the prognostic evaluation of CRC. Laparoscopic radical resection is a common surgical approach for treating CRC. However, research on the link between preoperative imaging and short-term prognosis in this context is limited. We hypothesized that specific preoperative imaging features can predict the short-term prognosis in patients undergoing laparoscopic CRC resection.
AIM
To investigate the imaging features of CRC and analyze their correlation with the short-term prognosis of laparoscopic radical resection.
METHODS
This retrospective study conducted at the Affiliated Cancer Hospital of Shandong First Medical University included 122 patients diagnosed with CRC who underwent laparoscopic radical resection between January 2021 and February 2024. All patients underwent magnetic resonance imaging (MRI) and were diagnosed with CRC through pathological examination. MRI data and prognostic indicators were collected 30 days post-surgery. Logistic regression analysis identified imaging features linked to short-term prognosis, and a receiver operating characteristic (ROC) curve was used to evaluate the predictive value.
RESULTS
Among 122 patients, 22 had irregular, low-intensity tumors with adjacent high signals. In 55, tumors were surrounded by alternating signals in the muscle layer. In 32, tumors extended through the muscular layer and blurred boundaries with perienteric adipose tissue. Tumor signals appeared in the adjacent tissues in 13 patients with blurred gaps. Logistic regression revealed differences in longitudinal tumor length, axial tumor length, volume transfer constant, plasma volume fraction, and apparent diffusion coefficient among patients with varying prognostic results. ROC analysis indicated that the areas under the curve for these parameters were 0.648, 0.927, 0.821, 0.809, and 0.831, respectively. Sensitivity values were 0.643, 0.893, 0.607, 0.714, and 0.714, and specificity 0.702, 0.904, 0.883, 0.968, and 0.894 (P < 0.05).
CONCLUSION
The imaging features of CRC correlate with the short-term prognosis following laparoscopic radical resection. These findings provide valuable insights for clinical decision-making.
Large left atrial myxoma with synchronous laryngeal squamous cell carcinoma: A case report
Authors: Zhu Ling , Neo Jax Yuan-Zhe , Punjabi Lavisha S , Lai Siang-Hui , Chua Yeow-Leng 
Published: February 2025

BACKGROUND
Cardiac myxoma is a benign neoplasm and one of the most common types of primary cardiac tumors. Synchronous cardiac myxoma and other malignancies are extremely rare, and only limited cases have been reported.
CASE SUMMARY
We describe a young patient with newly diagnosed locally advanced laryngeal cancer, with a synchronous cardiac tumor detected on staging scans. An echocardiogram showed the typical appearance of myxoma in the left atrium. Early cardiac surgery was performed in view of its obstructive features and post cardiac surgery recovery was uneventful. The patient was scheduled for subsequent oncological treatment for the laryngeal cancer. However, due to rapid progression of the advanced laryngeal malignancy, he was placed on supportive care.
CONCLUSION
To our knowledge, this is the first reported case of synchronous cardiac myxoma with laryngeal malignancy. Individualized treatment strategy should be adopted to manage synchronous tumors in a multidisciplinary approach. The most life-threatening condition needs be treated first. Single resection, staged operations or simultaneous resection of both tumors have been reported with good outcomes.
Survey on threatened medicinal plants diversity of Northwestern Syria
Authors: Aldarvish Munzer , Al Kaddour Anas , Bourgol Akram , Ramazan Yasser , Hallak Yousef , Cavers Stephen , Cottrell Joan 
Published: February 2025

Throughout history, many plant species have been used as natural medicines to prevent and treat human diseases. Due to its geographical location, climate, and history, Syria contains a remarkable diversity of medicinal plants. However, in recent years a prolonged period of conflict has resulted in widespread ecosystem destruction, human population displacement, and disruption of farming practices. Although poorly documented this is believed to have resulted in a significant decline in medicinal plant populations. ex situ conservation initiatives, the locations of medicinal plants exposed to deterioration were identified from the results of a questionnaire. Seeds from seven species: chamomile (Matricaria chamomilla L.), wild thyme (Thymus capitatus L.), sage (Salvia officinalis L.), hyssop (Hyssopus officinalis L.), caper (Capparis spinosa L.), basil (Ocimum basilicum L.), and watercress (Nasturtium officinale R. BR.) were collected for the establishment of ex situ collections in the future. We discuss the potential for recovery initiatives to protect and conserve these species and to support the sustainable use of medicinal plant genetic resources in Northern Syria. Such endeavours are vital for the continued well-being of the Syrian population and humanity as a whole.
Estimation of sST2 and CXCR3 levels in serum of patients with chronic and acute pyelonephritis caused by E. coli
Authors: Dhafer Rahman Abed Aljanabi  
Published: February 2025

Background: Pyelonephritis is a serious and widespread infection of the kidneys, commonly caused by Gram negative bacteria.This study aims to evaluate the immunomodulatory roles of sST2 and CXCR3 in the blood serum of patients suffering from acute and chronic pyelonephritis. Objectives: The main objectives of this study were to: Investigate the serum levels of sST2 and CXCR3 in patients with acute and chronic pyelonephritis. Compare the levels of these biomarkers between pyelonephritis patients and healthy controls. Determine the potential of sST2 and CXCR3 as diagnostic indicators for pyelonephritis.
Karakterstyrker: Treffsikkerheten av selvvurderinger og andres vurderinger
Authors: Skillingstad Johanne Bjørgum , Kjærstad Åsa Frostad , Bang Henning 
Published: February 2025

Sammendrag
Studien undersøker treffsikkerheten i andres vurderinger av kadetters karakterstyrker, og hvorvidt det er selvvurdering eller gjennomsnittet av andres vurderinger som gir det mest treffsikre bildet. Vi benyttet de tre kriteriene til Funder og West (1993) for å vurdere treffsikkerheten av andres vurderinger: (1) positiv korrelasjon mellom selvvurdering og andres vurderinger av egenskapen, (2) konsensus mellom andres vurderinger av egenskapen og (3) at andres vurderinger av egenskapen korrelerer positivt med relevante utfallsmål. Hvis kriteriene ble oppfylt, tok vi dette som indikasjon på at andres vurderinger er treffsikre. Hvis andres vurderinger i tillegg korrelerte høyere med relevante utfallsmål enn selvvurderinger, tok vi dette som en indikasjon på at andres vurderinger er mer treffsikre enn selvvurderinger. De tolv karakterstyrkene som ble vurdert, var lederskap, integritet, dømmekraft, utholdenhet, mot, lagspiller, rettferdighet, sosial intelligens, læringslyst, selvregulering, perspektiv og kreativitet. Utfallsmålene var militære og akademiske prestasjoner. 181 kadetter fra Krigsskolen deltok i studien. Vi fant statistisk signifikante positive korrelasjoner mellom selvvurdering og andres vurderinger for elleve karakterstyrker, og moderat til høy konsensus mellom andres vurderinger for alle karakterstyrker. Videre fant vi statistisk signifikante positive korrelasjoner mellom andres vurderinger og akademiske prestasjoner for elleve av tolv karakterstyrker, men kun for én selvvurdert karakterstyrke. Når det gjaldt sammenhengen mellom andres vurderinger og militære prestasjoner, fant vi statistisk signifikante positive korrelasjoner for alle tolv karakterstyrker, og for syv av de selvvurderte karakterstyrkene. Funnene indikerer at andres vurderinger er mer treffsikre enn selvvurderinger for elleve av tolv karakterstyrker.
Nøkkelord: karakterstyrker, selvvurderinger, andres vurderinger, akademisk prestasjon, militær prestasjon
Raízes do mito da branquitude no Rio Grande Do Sul, um olhar pela obra de Jorge Salis Goulart
Authors: Lima Maurício Lopes 
Published: February 2025

O artigo revisita uma obra clássica do pensamento histórico e sociológico do Rio Grande do Sul, A Formação do Rio Grande do Sul, de 1927, de Jorge Salis Goulart, um influente intelectual gaúcho que, com esta obra, oferece um paradigma importante para a interpretação da formação da sociedade sulina, e contribui para uma construção ideológica que perdura contemporaneamente sobre uma representação embranquecida do Rio Grande do Sul. O foco é demonstrar como a obra introduz, pela primeira vez, uma leitura racializada do Rio Grande do Sul, reproduzindo, naquele contexto, o debate contemporâneo sobre raça. Ao mesmo tempo, procura-se demonstrar o quanto essas interpretações foram fortemente ideológicas e, no limite, distorceram a realidade empírica, contribuindo para exercer uma violência simbólica quanto à representação do negro na sociedade sul-rio-grandense.
ФОРМИРОВАНИЕ УСТОЙЧИВОЙ ЭКОСИСТЕМЫ КРУПНОГО ПРЕДПРИНИМАТЕЛЬСКОГО СУБЪЕКТА: СТРАТЕГИИ АДАПТАЦИИ К ВНЕШНИМ ОГРАНИЧЕНИЯМ
Authors: АКИМОВА О.Е. , КОЖУХОВА М.Т. , АЙБАЗОВ М.И. 
Published: February 2025

Формирование экосистем предпринимательства является перспективным направлением устойчивого развития бизнеса и современной экономики в целом в условиях неопределенности. Она создает благоприятные условия для инноваций, роста и развития компаний, способствуя повышению конкурентоспособности и улучшению качества жизни населения. В статье рассмотрены основные ограничители и вызовы функционирования предпринимательства на современном этапе. Далее рассмотрены основные актуальные стратегии формирования экосистемы предпринимательства (использование синергетических эффектов коллаборации, развитие инноваций, использование практик корпоративной социальной ответственности). Также в статье примеры успешных кейсов крупных компаний, успешно адаптировавшихся к внешним ограничениям на основе применения экосистемного подхода на практике.
The formation of business ecosystems is a promising direction for the sustainable development of business and the modern economy as a whole in conditions of uncertainty. It creates favorable conditions for innovation, growth and development of companies, contributing to increasing competitiveness and improving the quality of life of the population. The paper considers the main constraints and challenges of the functioning of entrepreneurship at the present stage. Next, the main relevant strategies for the formation of the ecosystem of entrepreneurship (the use of synergetic effects of collaboration, the development of innovations, the use of corporate social responsibility practices) are considered. The paper also contains examples of successful cases of large companies that have successfully adapted to external constraints based on the application of the ecosystem approach in practice.