bluuebunny/crossref_metadata_2025_split huggingface dataset:
Discovery of a novel dual-targeting D-peptide to block CD24/Siglec-10 and PD-1/PD-L1 interaction and synergize with radiotherapy for cancer immunotherapy
Authors: Shen Wenhui , Shi Peishang , Dong Qingyu , Zhou Xiuman , Chen Chunxia , Sui Xinghua , Tian Wentong , Zhu Xueqin , Wang Xiaoxi , Jin Shengzhe , Wu Yahong , Chen Guanyu , Qiu Lu , Zhai Wenjie , Gao Yanfeng 
Published: June 2023

BackgroundAside from immune checkpoint inhibitors targeting programmed cell death protein 1 (PD-1) and programmed death ligand 1 (PD-L1), intervention of CD47/Sirpα mediated ‘don’t eat me’ signal between macrophage and tumor cell is considered as a promising therapeutic approach for cancer immunotherapy. Compared with CD47, the novel immune checkpoint CD24/Siglec-10 can also deliver ‘don’t eat me’ signal and CD24 shows much lower expression level in normal tissue which might avoid unwanted side effects.MethodsCell-based phage display biopanning and D-amino acid modification strategy were used to identify the CD24/Siglec-10 blocking peptide. Cell-based blocking assay and microscale thermophoresis assay were used to validate the blocking and binding activities of the peptide. Phagocytosis and co-culture assays were used to explore the in vitro function of the peptide. Flow cytometry was performed to assess the immune microenvironment after the peptide treatment in vivo.ResultsA CD24/Siglec-10 blocking peptide (CSBP) with hydrolysis-resistant property was identified. Surprisingly, we found that CSBP could not only block the interaction of CD24/Siglec-10 but also PD-1/PD-L1. CSBP could induce the phagocytosis of tumor cell by both the macrophages and monocytic myeloid-derived suppressor cells (M-MDSCs), which can further activate CD8+T cells. Besides, combination of radiotherapy and CSBP synergistically reduced tumor growth and altered the tumor microenvironment in both anti-PD-1-responsive MC38 and anti-PD-1-resistant 4T1 tumor models.ConclusionsIn summary, this is the first CD24/Siglec-10 blocking peptide which blocked PD-1/PD-L1 interaction as well, functionedviaenhancing the phagocytosis of tumor cells by macrophages and M-MDSCs, and elevating the activity of CD8+T cells for cancer immunotherapy.
New hormone receptor-positive breast cancer mouse cell line mimicking the immune microenvironment of anti-PD-1 resistant mammary carcinoma
Authors: Perez-Lanzon Maria , Carbonnier Vincent , Cordier Pierre , De Palma Fatima Domenica Elisa , Petrazzuolo Adriana , Klein Christophe , Arbaretaz Floriane , Mangane Khady , Stoll Gautier , Martins Isabelle , Fohrer Ting Helene , Paillet Juliette , Mouillet-Richard Sophie , Le Corre Delphine , Xiao Wenjjin , Sroussi Marine , Desdouets Chantal , Laurent-Puig Pierre , Pol Jonathan , Lopez-Otin Carlos , Maiuri Maria Chiara , Kroemer Guido 
Published: June 2023

BackgroundProgress in breast cancer (BC) research relies on the availability of suitable cell lines that can be implanted in immunocompetent laboratory mice. The best studied mouse strain, C57BL/6, is also the only one for which multiple genetic variants are available to facilitate the exploration of the cancer-immunity dialog. Driven by the fact that no hormone receptor-positive (HR+) C57BL/6-derived mammary carcinoma cell lines are available, we decided to establish such cell lines.MethodsBC was induced in female C57BL/6 mice using a synthetic progesterone analog (medroxyprogesterone acetate, MPA) combined with a DNA damaging agent (7,12-dimethylbenz[a]anthracene, DMBA). Cell lines were established from these tumors and selected for dual (estrogen+progesterone) receptor positivity, as well as transplantability into C57BL/6 immunocompetent females.ResultsOne cell line, which we called B6BC, fulfilled these criteria and allowed for the establishment of invasive estrogen receptor-positive (ER+) tumors with features of epithelial to mesenchymal transition that were abundantly infiltrated by myeloid immune populations but scarcely by T lymphocytes, as determined by single-nucleus RNA sequencing and high-dimensional leukocyte profiling. Such tumors failed to respond to programmed cell death-1 (PD-1) blockade, but reduced their growth on treatment with ER antagonists, as well as with anthracycline-based chemotherapy, which was not influenced by T-cell depletion. Moreover, B6BC-derived tumors reduced their growth on CD11b blockade, indicating tumor sustainment by myeloid cells. The immune environment and treatment responses recapitulated by B6BC-derived tumors diverged from those of ER+TS/A cell-derived tumors in BALB/C mice, and of ER–E0771 cell-derived and MPA/DMBA-induced tumors in C57BL/6 mice.ConclusionsB6BC is the first transplantable HR+BC cell line derived from C57BL/6 mice and B6BC-derived tumors recapitulate the complex tumor microenvironment of locally advanced HR+BC naturally resistant to PD-1 immunotherapy.
Trajectory of a medical career: a perspective regarding a proposed model
Authors: Stoller James K 
Published: June 2023

A career as a physician offers so many options—clinical care, research, education, leadership, etc. Still, a general trajectory of a medical career can be usefully modelled. Based on a USA-centric lens, this proposed model—which is based on a personal reflection and conversation with colleagues—consists of an initial two-component linear phase, followed later by a non-linear phase. The linear phase requires mastery of a large body of knowledge, acquiring cognitive and technical skills, and achieving prescribed milestones. Two components of the linear trajectory are early education through medical school, and then graduate medical education through the initial career path. A non-linear phase follows, characteristically beginning after graduate medical training and the initial ‘hitting stride’ in the first post-training position.At this point, the physician’s choices regarding career direction are wide open. Yet, the intense focus needed to master the prolonged linear phase of the physician’s career can exert opposing effects on preparedness for the subsequent non-linear phase; years of satisfying prescribed curricula and examinations may blunt the self-directed learning and intrinsic motivation needed for the non-linear phase while also stimulating the appetite to get beyond the guardrails of the linear phase.This model has implications for early training, namely encouraging a focus on mindfulness and introducing this model as part of professional identity formation. Given differences in medical training across the globe, generalisability of the model to settings outside the United States would require validation by others.
Five hats of effective leaders: teacher, mentor, coach, supervisor and sponsor
Authors: Winters Richard C , Chan Teresa M , Barth Bradley E 
Published: June 2023

Background/aimTeaching, mentoring, coaching, supervising and sponsoring are often conflated in the literature. In this reflection, we clarify the distinctions, the benefits and the drawbacks of each approach. We describe a conceptual model for effective leadership conversations where leaders dynamically and deliberately ‘wear the hats’ of teacher, mentor, coach, supervisor and/or sponsor during a single conversation.MethodsAs three experienced physician leaders and educators, we collaborated to write this reflection on how leaders may deliberately alter their approach during dynamic conversations with colleagues. Each of us brings our own perspective and lens.ResultsWe articulate how each of the ‘five hats’ of teacher, mentor, coach, supervisor and sponsor may help or hinder effectiveness. We discuss how a leader may ‘switch’ hats to engage, support and develop colleagues across an ever-expanding range of contexts and settings. We demonstrate how a leader might ‘wear the five hats’ during conversations about career advancement and burn-out.ConclusionEffective leaders teach, mentor, coach, supervise and sponsor during conversations with colleagues. These leaders employ a deliberate, dynamic and adaptive approach to better serve the needs of their colleagues at the moment.
An anisotropic stellar fluid configuration with vanishing complexity
Authors: Andrade J. , Santana D. 
Published: June 2023

AbstractIn this work, we construct a new stellar model in the regime of anisotropic fluid pressure using the concept of vanishing complexity for spherically symmetric fluid distributions (Herrera in Phys Rev D 97:044010, 2018) and a convenient ansatz in order to close the Einstein’s field equations. The resulting model fulfills the fundamental physical acceptability stellar conditions for a specific set of compactness factor. The stability and its response against fluctuations in the matter sector is also investigated.
Pentaquark interpretation of $$\Lambda _{c}$$ states in the quark model
Authors: Yan Ye , Hu Xiaohuang , Wu Yuheng , Huang Hongxia , Ping Jialun , Yang Youchang 
Published: June 2023

AbstractMotivated by the recent observation of the$$\Lambda _c(2910)^+$$Λc(2910)+state in the$$\Sigma _{c}(2455)^{0,++}\pi ^{\pm }$$Σc(2455)0,++π±spectrum by the Belle Collaboration, we investigate the explanation of$$\Lambda _{c}$$Λcstates within the pentaquark framework using the quark delocalization color screening model (QDCSM). To check for bound states and resonance states, we utilize the real-scaling method. Additionally, we calculate the root mean square of cluster spacing to study the structure of the states and further estimate whether a state is a resonance state or not. Our numerical results show that$$\Lambda _{c}(2910)$$Λc(2910)cannot be interpreted as a molecular state, and$$\Sigma _{c}(2800)$$Σc(2800)cannot be explained as theNDmolecular state with$$J^P=1/2^-$$JP=1/2-. However, we find that$$\Lambda _{c}(2595)$$Λc(2595)can be interpreted as a molecular state with$$J^P=\frac{1}{2}^-$$JP=12-, where the main component is$$\Sigma _{c}\pi $$Σcπ. Similarly, we interpret$$\Lambda _{c}(2625)$$Λc(2625)as a molecular state with$$J^P=\frac{3}{2}^-$$JP=32-, where the main component is$$\Sigma _{c}^{*}\pi $$Σc∗π. We also suggest that$$\Lambda _{c}(2940)$$Λc(2940)is likely to be interpreted as a molecular state with$$J^P=3/2^-$$JP=3/2-, where the main component is$$ND^{*}$$ND∗. In addition, we predict two new states: a$$J^P=3/2^-$$JP=3/2-$$\Sigma _{c}\rho $$Σcρresonance state with a mass of 3140–3142 MeV, and a$$J^P=\frac{5}{2}^-$$JP=52-$$\Sigma _{c}^*\rho $$Σc∗ρstate with a mass about 3187–3188 MeV.
A Wideband Highly Efficient Omnidirectional Compact Antenna for WiMAX/Lower 5G Communications
Authors: Paul Liton Chandra , Ankan Sarker Saleh Ahmed , Rani Tithi , Karaaslan Muharrem , Hossain Md. Najmul , Al-Gburi Ahmed Jamal Abdullah , Saha Himel Kumar , Alkurt Fatih Özkan 
Published: June 2023

Microstrip patch antenna (MPA) is widely used for different wireless communications such as WiMAX and fifth generation (5G). In this paper, a wideband, highly efficient, omnidirectional, compact novel patch antenna has been designed and reported for WiMAX/lower 5G communications. The proposed compact MPA is made on Rogers RT 5880 (

ɛ

r

=
2.2

and

tan

δ

=
0.0009

). The physical volume of the MPA is compact (

32
×
32
×
0.79

mm3). The MPA consists of seven small square-shaped elements that are diagonally connected with each other. The 7-element antenna works at 3.592 GHz with a suitable reflection coefficient of -46.78 dB and a -10 dB bandwidth (BW) of 1.40 GHz, covering 3.10-4.50 GHz. The apex gain (

G

) and the directivity (

D

) of the designed prototype are 3.90 dB and 4.20 dBi, respectively. The antenna maintains a high efficiency of 94-98% over the 3.10-4.50 GHz operating range. The VSWR of the antenna is close to unity, which is 1.0092 at 3.592 GHz. Initially, CST is used to design the antenna, and then, all the properties have been buttressed by using high frequency structure simulator (HFSS). Finally, a prototype of the compact 7-element antenna has been developed and measured. Owing to getting good results for the intended applications, the presented compact antenna can be a reliable candidate for WiMAX (3.4-3.6 GHz) and lower 5G (3.3-4.2 GHz).
The Hagiographic Dossier of Ss Cyrus and John and Its Latin Translations
Authors: Ronconi Filippo 
Published: June 2023

Abstract
This article focuses on the western cult of two saints, Cyrus and John, which was founded in Egypt – where Sophronios of Jerusalem composed the anargyroi’s hagiographic dossier in the seventh century – and quickly spread to Italy. The analysis of the manuscripts containing the Latin translations of Sophronios’s texts allows us to trace the diffusion of this hagiographic corpus in Rome, and to link its transfer and first reception in Italy to a broad Mediterranean migration.
The Awkwardness of American Exceptionalism
Authors: Furey Constance M. 
Published: June 2023

Abstract
American exceptionalism poses particular methodological challenges for the historian of religion. This essay acknowledges the importance of privileging historical specificity, as modeled by Dana Logan’s study of America’s formative forms of governance in her recent book, Awkward Rituals, but then argues history should be put in service to theory. It does so by arguing that Logan’s own ritual theory undermines rather than reinforces American exceptionalism – an argument reinforced with comparative examples from other eras of Christian history.
Early Safavid Campaigns in the Caucasus
Authors: Anooshahr Ali 
Published: June 2023

Abstract
The chronicle of Qasim Beg Hayati of Tabriz, written during the reign of Shah Tahmasp (d. 1576), provides new information on early Safavid history that is absent from the other Persian historical literature of the sixteenth and seventeenth centuries. In particular, Hayati shows how important the Caucasus was for the rise of Shaykh Junayd (d. 1460) and Shaykh Haydar Safavi (d. 1488). Using plunder and slaves gained from raids on the Circassians and the Georgians, Junayd and Haydar maneuvered themselves into a position of leadership of their familial order to which they were not entitled by birth. The disastrous ends of both men meant that there could be little continuity in the movement, but they still placed their line at the head of the shrine of Ardabil, and bequeathed to the young Shah Isma’il (d. 1524) a few surviving veterans with valuable experience about campaigning.
Ubykh Personal Names
Authors: Chirikba Viacheslav A. 
Published: June 2023

Abstract
The paper presents a survey of the system of Ubykh personal names. The traditional structure of Ubykh names was binary, consisting of a surname and a postposed personal name. Alternative structures included a preposed family name plus two or more personal names, or a surname, plus a patronymic, plus a personal name. Besides a few native Ubykh names, the majority of names are “Oriental” (Turkish/Turkic, Arabic, Jewish, Persian, etc.), Circassian or Abkhazian, or of unclear origin. There are also hybrid names combining names or formants of different languages.
A Quest for Meaning: Interpretation of Article 73(3) of the Law of the Sea Convention by Indonesian Supreme Court
Authors: Liliansa Dita 
Published: June 2023

Abstract
In the spirit of conserving the balance between the interests of the coastal State and other States in the exclusive economic zone (eez), Article 73(3) of the United Nations Convention for the Law of the Sea (unclos) establishes that coastal State penalties for violations of fisheries laws and regulations may not include imprisonment or corporal punishment unless otherwise agreed by the States concerned. As one of the countries suffering from illegal fishing, Indonesia has seen a number of domestic cases challenging the practical application of Article 73(3) due to the failure of several offenders to pay monetary penalties for violating fisheries laws and regulations in Indonesia’s eez. Article 73(3) appears to be the only unclos provision that Indonesian courts have directly applied and interpreted into domestic cases. The debate revolves around whether courts can impose default confinement for fisheries offences in the eez. This article examines how Indonesian courts interpret the meaning and scope of the term ‘imprisonment’ within the ambit of Article 73(3) of unclos, particularly in the context of confinement for fine defaults, and whether international courts or tribunals provide any guidance in this interpretation.
South China Sea: Battle of the Diplomatic Notes among China and Non-Claimant States
Authors: Thao Nguyễn Hồng 
Published: June 2023

Abstract
The South China Sea disputes are becoming increasingly tense with more and more countries expressing their views on legal issues and actions of claimant Statess in the South China Sea. In December 2019, Malaysia deposited a partial submission to the United Nations Commission on the Limits of the Continental Shelf to establish the limits of its extended continental shelf beyond 200 nautical miles in the northern part of the South China Sea. The submission sparked a new legal battle of diplomatic notes with the participation of South China Sea coastal States which can also be regarded as claimant States in the contet of the South China Sea disputes (Brunei, China, Malaysia, the Philippines and Viet Nam) as well as non-claimant States (Australia, France, Germany, Indonesia, Japan, New Zealand, the United Kingdom and the United States). Following the article “South China Sea: New Battle of the Diplomatic Notes among claimants in 2019–2021” published in the Asia-Pacific Journal of Ocean Law and Policy 6 (2021), this paper provides an analysis of the exchange of diplomatic notes between China and non-claimant States with the aim of understanding the impact of these exchanges on the prospect for the peaceful settlement of the maritime disputes in the South China Sea.
Kierkegaard’s Pessimism
Authors: Jepsen Per 
Published: June 2023

Abstract
The article aims at reconstructing Kierkegaard’s reception of Schopenhauer’s philosophy with the purpose of discussing the pessimism of Kierkegaard’s late writings. The thesis of the article is that the theology of the late Kierkegaard that lies behind his attack on the so-called ‘Christendom’ and, in a wider perspective, on Protestantism in general, must be characterized as ‘pessimistic,’ insofar as it considers the mundane world as fundamentally ‘wicked’ or ‘wretched.’ Accordingly, a certain tendency toward asceticism and denial of the world becomes a distinctive feature of Kierkegaard’s late works and of his interpretation of Christianity. Kierkegaard’s pessimism is, however, limited to his view of the mundane world, and he does not, like Schopenhauer, consider human existence fundamentally meaningless and purposeless. On the contrary, it is the aim of life for the true Christian, according to Kierkegaard, to obtain eternal salvation through self-chosen suffering and negation of his or her own desires for temporal gratification.
Morocco Reimagined
Authors: El Guabli Brahim 
Published: June 2023

Abstract
This article rereads the works of Carlos de Nesry and Abraham Serfaty, two important Jewish intellectuals from Morocco, to conceptualize their theorization of state and society in post-1956 Morocco. The article argues that Moroccan Jews’ striving for an inclusive citizenship in and belonging to the independent nation took several forms, but the most salient of which were the two embodied in the work of de Nesry and Serfaty. Although there is a robust literature on Moroccan Jews, these theorizations have not received the scholarly examination they deserve nor have they been put in dialogue with each other to tease out their significance for the situation of Jews in the Moroccan context. This article is an attempt to bring attention to the implications of a locally produced Jewish political theory for the larger Moroccan nation. By examining de Nesry’s and Serfaty’s writing against the background of political repression and increasing authoritarianism, I show how Jewish intellectuals navigated their place in a fast-changing post-independence country, furnishing ideas and projects that could have created a different Morocco.
Understanding the Forcing Mechanisms of the 1931 Summer Flood along the Yangtze River, the World’s Deadliest Flood on Record
Authors: Zhou Yueqi , Zhou Tianjun , Jiang Jie , Chen Xiaolong , Wu Bo , Hu Shuai , Wu Mingna 
Published: June 2023

Abstract
The 1931 Yangtze River flood in eastern China, which had an associated death toll of over 2 million, is regarded as one of the world’s deadliest natural disasters on record. However, due to the lack of meteorological data before the 1950s, the causes of this event are rarely investigated. Here, we combine multiple lines of evidence from recently available historical observations, reanalysis datasets, and atmospheric general circulation model simulations driven by historical sea surface temperatures (SSTs) that cover the early twentieth century to reveal the physical mechanisms underlying this flood. We find that the flooding in 1931 along the Yangtze River valley was dominated by July rainfall. Although the rainfall totals in July 1931 were not the largest in history (ranking second over the past century), the totals exceeded those for many other pluvial years between 1951 and 2010 in terms of its persistence, which was associated with a steady western Pacific subtropical high (WPSH). The flooding resulted from the combined effects of tropical El Niño–related SST forcing and extratropical wave activities over the Eurasian continent. On the one hand, warm SST anomalies in the tropical Indian Ocean following an El Niño event led to the southwestward extension of the WPSH. On the other hand, the southward shift of the westerly jet due to extratropical wave activities prevented the normal northward movement of the WPSH typical in July. Additionally, the impact that the preceding springtime precipitation and soil moisture had on the summer flood of 1931 is also discussed.
Post-surgical discharge opioid prescribing, use and handling after introduction of a stewardship program
Authors: Allen Megan L , Silva Anurika P De , Braat Sabine , Jones Karin , Chia Angela , Hucker Timothy R , Brooks Sally L , Hogg Malcolm , Lee Chuan-Whei , Williams Daryl L , Kim Charles C 
Published: June 2023

Summary Opioids are often used to provide postsurgical analgesia but may cause harm if used inappropriately. We introduced an opioid stewardship program in three Melbourne hospitals to reduce the inappropriate use of opioids after patient discharge. The program had four pillars: prescriber education, patient education, a standardised quantity of discharge opioids, and general practitioner (GP) communication. Following introduction of the program, we undertook this prospective cohort study. The study aimed to describe post-program discharge opioid prescribing, patient opioid use and handling, and the impact of patient demographics, pain and surgical treatment factors on discharge prescribing. We also evaluated compliance with the program components. We recruited 884 surgical patients from the three hospitals during the ten-week study period. Discharge opioids were dispensed to 604 (74%) patients, with 20% receiving slow-release opioids. Junior medical staff undertook 95% of discharge opioid prescribing, which was guideline-compliant for 78% of patients. Of the patients discharged with opioids, a GP letter was sent for only 17%. Follow-up at two weeks was successful in 423 (70%) patients and in 404 (67%) at three months. At the three-month follow-up, 9.7% of patients reported ongoing opioid use; in preoperatively opioid naïve patients, the incidence was 5.5%. At the two-week follow-up, only 5% reported disposal of excess opioids, increasing to 26% at three months. Ongoing opioid therapy at three months in our study cohort (9.7%; 39/404) was associated with preoperative opioid consumption and higher pain scores at the three-month follow-up. The introduction of the opioid stewardship program resulted in highly guideline-compliant prescribing, but hospital-to-GP communication was uncommon and opioid disposal rates were low. Our findings suggest that opioid stewardship programs can improve postoperative opioid prescribing, use and handling, but the realisation of these gains will require effective program implementation.