bluuebunny/crossref_metadata_2025_split huggingface dataset:
A systematic review using thematic analysis exploring cultural competence in pharmacy education: What is done? How is it done? What does it mean?
Authors: Jarrar Rawand , Lim Rosemary , Richardson Charlotte Lucy , Naqvi Atta Abbas , Rathbone Adam Pattison , Lau Wing Man 
Published: January 2023

Abstract
Background: There is an increased need for a healthcare workforce that is culturally competent, to improve health outcomes and reduce health disparities for patients from diverse cultural backgrounds. This is important in the context of pharmaceutical care for patients, as the inability to recognise a patient’s health beliefs, which could be influenced by their cultural background, can lead to reduced medication adherence and poor treatment outcomes. This systematic review aims to explore cultural competence teaching and training in pre-qualification pharmacy education.
Methods: Medline, Scopus, PsychInfo, Web of Knowledge, CINAHL, and Embase databases were systematically searched for studies that explored cultural competence in pharmacy education and were published in English from January 2012 to December 2021. Methodological quality of studies was assessed using the Mixed Methods Appraisal Tool (MMAT). Data from included studies were thematically analysed.
Results: Overall, 47 papers (46 studies) were included in the review. Of these, 40 papers focused on interventions for teaching cultural competence to pharmacy students only, the remaining studies included students from pharmacy and other health discipline programmes. Half of the studies focused on cultural competence in general (n = 20, 50%), while the remaining studies focused on competence on specific aspects e.g., cultures, religions and disabilities. Most studies (n = 24, 60%) report implementation of interventions that took place over a week. Twenty-one studies reported that cultural competence interventions were compulsory. There were variations in how cultural competence is conceptualised in studies; some studies focused on the need to increase knowledge about different cultures or ‘knowing how’; other studies focused on behavioural aspects that would help students while they work with patients from diverse backgrounds, or ‘showing how’; some studies described cultural competence as a continuum that includes both ‘doing’ knowledge and behavioural aspects.
Conclusion: There is variation in how cultural competence is taught in pharmacy education programmes, which could be a consequence of differences in how authors conceptualised cultural competence. Further research is needed to develop a unified understanding of the meaning of cultural competence and how it should be taught to pharmacy students.
TRAF6 promotes chemoresistance to paclitaxel of triple negative breast cancer via regulating PKM2-mediated glycolysis
Authors: Xu Han , Li Longzhi , Dong Bing , Lu Ji , Zhou Kun , Yin Xiaoxin , Sun Huizhen 
Published: January 2023

Abstract

Ample evidence reveals that glycolysis plays an important role in cancer progression; however, the underlying mechanism of its drug resistance is still worth being further explored. TRAF6, a E3 ubiquitin ligase, is well known to overexpress in various types of cancers, which predicts poor prognosis. In our study, we discovered that TRAF6 expressed more significantly in triple negative breast cancer (TNBC) than in other subtypes of breast cancers, promoting chemoresistance to paclitaxel; that the inhibited TRAF6 expression in the chemoresistant TNBC (TNBC-CR) cells enhanced the sensitivity by decreasing glucose uptake and lactate production; that TRAF6 regulated glycolysis and facilitated chemoresistance via binding directly to PKM2; and that overexpressing PKM2 in the TNBC-CR cells with TRAF6 knocked down regained significantly TRAF6-dependent drug resistance and glycolysis. Additionally, we verified that TRAF6 could facilitate PKM2-mediated glycolysis and chemoresistance in the animal models and clinical tumor tissues. Thus, we identified the novel function of TRAF6 to promote glycolysis and chemoresistance in TNBC by regulating PKM2, which could provide a potential therapeutic target for TNBC treatment.
Apoptotic effect of Linoelaidic acid isolated from Marine Tapra fish oil (Ophisthopterus tardoore) via ROS generation and caspase activation on Apoptotic effect of Linoelaidic acid isolated from Marine Tapra fish oil (Ophisthopterus tardoore) via ROS generation and caspase activation on MCF cell line”
Authors: Dutta Ananya , Panchali Titli , Khatun Amina , Jarapala Sreenivasa Rao , Das Koushik , Ghosh Kuntal , Chakrabarti Sudipta , Pradhan Shrabani 
Published: January 2023

AbstractThe implication of inflammation in the pathophysiology of several types of cancers has been under intense investigation. Conjugated fatty acids can modulate inflammation and present anticancer effects, promoting cancer cell death. In this paper, we evaluated the efficacy of new conjugated fatty acids isolated from marineOpisthopterus tardoore(Tapra fish) in human breast cancer cell lines MCF7. Linoelaidic acid, a marine fish (O. tardoore) derived unsaturated fatty acids, showed effective anticancer activity against MCF-7. MTT assay revealed a dose-dependent decline in cancer cell viability. It was noteworthy that 5 µM linoelaidic acid decreased the MCF-7 cell viability by 81.82%. Besides that, linoelaidic acid significantly (p < 0.05) increased the level of TNF-α and IL-1ra studied by ELISA. Not only that, linoelaidic acid significantly decreased the reduced glutathione level and increased the oxidized glutathione level in MCF-7 cells indicating the oxidative stress inside the cell. Two different cell staining methods with acridine orange-ethidium bromide and DAPI confirmed that the linoelaidic acid rendered their detrimental effect on cancer cells. To decipher the mode of apoptosis Western blotting was performed in which the expression pattern of several proteins (p53, IL 10, and IL 1ra) established the apoptosis in the studied cell lines after linoelaidic acid exposure. Hence it may be conferred that linoelaidic acid has prompt anticancer activity. So, this drug can be used further for the treatment of cancer.
Occurrence of microplastics in commercial fish species from the Ethiopian rift valley's Lake Hawassa, Ethiopia
Authors: Demsie Asrat Fekadu , Yimer Girma Tilahun 
Published: January 2023

Abstract

Microplastics (MPs) have recently been detected as emergent pollutants in the Ethiopian rift valley lakes located close to rapidly expanding towns. We provide the first study of MPs ingestion of commercial fish species from Lake Hawassa, Ethiopia: Catfish (Clarias gariepinus) and Nile Tilapia (Oreochromis niloticus). A total of 60 individual fish species was collected from three sampling sites of lake Hawassa in October 2020. Across all sampling sites, there was a significant difference in ingested MPs between benthic omnivore catfish and pelagic Phyto planktivorous Tilapia (χ2 = 15.864, p < 0.001). The most common size of ingested MPs (84.6%) was 0.5-1 mm, with fragments (59.5%) dominating, followed by fibers (25.4%). On average, 4.03 ± 1.33 MPs with sizes ranging between 60 µm and 10.53 mm were detected per individual. White and yellow MPs were particularly numerous, accounting for 36.8% and 26.4% of the total, respectively. Because Lake Hawassa's fishery is so significant, the potential impact of MP pollution on the lake biota in general, and economically valuable fish species in particular, deserves attention, additional research, and, if possible, early mitigation.
DVH analysis for brachytherapy plaques and proton beam during intraocular tumor treatment using 3D film dosimetry
Authors: Eidi Taha , Aghamiri Seyed Mahmoud Reza , Baghani Hamid Reza 
Published: January 2023

Abstract
Proton therapy and plaque-based brachytherapy are considered efficient radiotherapy modalities for intraocular tumor irradiation. The current study aims to measure and compare the dosimetric features of these methods through a film dosimetry approach inside an eyeball phantom. A 3D-printed PLA (polylactic acid)-based eyeball phantom was applied for phantom irradiation. For brachytherapy, COMS and CGD plaques respectively containing the 125I and 106Ru radioactive sources were employed. Proton irradiation was performed using the clinical beamline of the CNAO oncological hadron therapy center. PDD (percentage depth dose), transverse dose profile, 2D and 3D dose distribution, as well as DVH (dose volume histogram) data relevant to the tumor volume and surrounding healthy tissues were measured for applied treatment techniques using Gafchromic EBT3 film dosimetry approach and compared together. A more uniform dose distribution inside the tumor volume was found in the case of the proton beam concerning two other techniques. Furthermore, a proton beam can better spare healthy organs distributed around the tumor region. Besides, COMS plaque can lead to better clinical outcomes concerning CGD plaque. Viewpoint to the dose uniformity inside the target volume as well as sparing the healthy tissues, proton therapy would be the optimal choice. On the other hand, the photon beam can be preferred to the electron beam if proton therapy facilities are not available. Nevertheless, based on the importance of the healthy organ which should be spared, the COMS or CGD plaque can be selected for radiotherapy.
Revisiting the Watching eyes effect: how emotional expressions, sex, and age of watching eyes influence the extent one would make stereotypical statements
Authors: Lau Wee Kiat , Sauter Marian , Bulut Cihan , Lisa Valentina Eberhardt , Huckauf Anke 
Published: January 2023

Abstract

The watching eyes effect influences people to behave more prosocially or less antisocially. It is currently unknown how the eyes themselves induce this effect. To fill this gap, we varied emotional expressions (angry, fear, happy, neutral), age (old, young), and sex (male, female) of the watching eyes to investigate which characteristics influence antisocial behavior. Participants rated the extent to which they would utter 36 stereotypical statements about race, gender, and religion topics. Each statement was presented together with one pair of eyes selected at random. Approval of stereotype statements with neutral eyes did not differ from control flower pictures. However, age, sex, and emotional expressions of the watching eyes influenced the extent to which participants would utter the statements: angry old male eyes increased stereotypical statements, as did happy young eyes (males and females). Fearful eyes decreased the extent to utter stereotypical statements, except for old female eyes. Our data suggest that studies presenting eyes that appear neutral may be a reason why replication of this effect was unsuccessful. Furthermore, the typical stylized eyes used in many watching eyes experiments could be interpreted as angry old male eyes to elicit changes in participants’ behaviors, like making donations or rating scales. We recommend further research to examine how necessary it is to look at the characteristics of watching eyes to better understand the mechanisms underlying this effect. Taken together, our findings show that the watching eyes effect on the extent to utter stereotypical statements may be better replicated with angry old male eyes or young happy eyes.
Modelling of icodextrin hydrolysis and kinetics during peritoneal dialysis
Authors: Stachowska-Pietka Joanna , Waniewski Jacek , Olszowska Anna , Garcia-Lopez Elvia , Wankowicz Zofia , Lindholm Bengt 
Published: January 2023

Abstract

In peritoneal dialysis, ultrafiltration is achieved by adding an osmotic agent into the dialysis fluid. During an exchange with icodextrin-based solution, polysaccharide chains are degraded by α-amylase activity in dialysate, influencing its osmotic properties. We modelled water and solute removal taking into account degradation by α-amylase and absorption of icodextrin from the peritoneal cavity. We analysed data from 16-hour dwells with icodextrin-based solution in 11 patients (8 icodextrin-naïve, 3 icodextrin-exposed) on dialysate volume, dialysate concentrations of glucose, urea, creatinine and α-amylase, and dialysate and blood concentrations of 7 icodextrin molecular weight fractions. The three-pore model was extended to describe hydrolysis of icodextrin by α-amylase. The extended model accurately predicted kinetics of ultrafiltration, small solutes and icodextrin fractions in dialysate, indicating differences in degradation kinetics between icodextrin-naïve and icodextrin-exposed patients. In addition, the model provided information on the patterns of icodextrin degradation caused by α-amylase. Modelling of icodextrin kinetics using a modified three-pore model that takes into account absorption of icodextrin and changes in α-amylase activity in the dialysate provided accurate description of peritoneal transport and information on patterns of icodextrin hydrolysis during long icodextrin dwells.
Effectiveness of Game-Based Teaching Method on Nursing Students’ Knowledge of Enhanced Recovery After Surgery (ERAS)
Authors: ABUMETTLEQ Ibrahim , BAYRAKTAR Nurhan , DİKMEN Burcu 
Published: January 2023

Abstract
Background
Technology is a creation of humans, so when an educator can implement technology in teaching, it is also innovative. New technology allows educators to provide various ways for media to address diverse learning styles, such as animation, live video, gaming, etc.
Objective
The current study aimed to define the effectiveness of the game-based teaching method on nursing students’ knowledge of ERAS. The study was conducted among 80 international nursing students.
Methods
The study was planned with randomized controlled design. The study was performed at a "[blinded for review]" faculty of Nursing.The students were designated erratically to the experimental grouping or control grouping (80 and 40 players in each group) through the census method. The Kahoot application which the game could be used by phone or by Computer.
Results
The findings of the study showed the improvement of the student's performance in the overall mean scores of all enhanced recovery after surgery after the educational intervention through game-based learning.
Conclusions
The findings indicate that game-based teaching improves quality outcomes for students' education. However, our results support the effectiveness of the game-based teaching method on nursing students’ knowledge of enhanced recovery after surgery; the method can be useful for developing educational strategies in nursing schools and nursing education.
Efficacy and safety of atezolizumab plus bevacizumab treatment for advanced hepatocellular carcinoma in the real world: a systematic review and single-arm meta-analysis
Authors: Gao Xiaoqiang , Zhao Rui , Ma Huaxing , Zuo Shi 
Published: January 2023

Abstract

Background Atezolizumab plus bevacizumab was approved in 2020 as a first-line treatment for advanced hepatocellular carcinoma (HCC). The purpose of this study was to assess the curative effect and tolerability of the combination treatment in advanced HCC. Methods Web of Science, PubMed and Embase were retrieved for qualified literatures on the treatment of advanced HCC with atezolizumab plus bevacizumab until September 1, 2022. The outcomes included pooled overall response (OR), complete response (CR), partial response (PR), median overall survival (mOS), median progression-free survival (mPFS), and adverse events (AEs). Results Twenty-three studies, comprising 3168 patients, were enrolled. The pooled OR, CR, and PR rates of the long-term (more than six weeks) therapy response based on Response Evaluation Criteria in Solid Tumors (RECIST) were 26%, 2%, and 23%, respectively. The pooled OR, CR, and PR rates of the short-term (six weeks) therapeutic response evaluated with RECIST were 13%, 0%, and 15%, respectively. The pooled mOS and mPFS were 14.7 months and 6.66 months, respectively. During the treatment, 83% and 30% of patients experienced any grade AEs and grade 3 and above AEs, respectively. Conclusions Atezolizumab in combination with bevacizumab showed good efficacy and tolerability in the treatment of advanced HCC. Compared with short-term, non-first-line, and low-dose therapy, atezolizumab plus bevacizumab in long-term, first-line, and standard-dose treatment for advanced HCC showed a better tumor response rate.
Mid-Holocene West African Monsoon Rainfall enhanced in high-resolution EC-Earth simulation with dynamic vegetation feedback
Authors: Berntell Ellen , Zhang Qiong 
Published: January 2023

Abstract
Proxy records have shown that the Mid-Holocene was a period of humid conditions across West Africa, with an enhanced West African Monsoon (WAM) and vegetated conditions in areas currently characterized by desert, often referred to as the Green Sahara. However, General Circulation Models regularly struggle with recreating this strengthened Mid-Holocene monsoon in West Africa. The vegetation-albedo feedback has long been viewed as an essential process modulating the monsoon variability in West Africa, and simulations using prescribed vegetation to recreate a Green Sahara have shown a strengthened WAM and increased rainfall. However, these simulations represent an idealized vegetation cover and do not take any environmental heterogeneity into account. Furthermore, this only represents a one-directional forcing by the vegetation on the climate rather than the vegetation-albedo feedback. Using idealized vegetation cover might therefore over-/underestimate the changes of the WAM, as well as over-/understate the importance of the vegetation feedback. To address this, we have simulated the Mid-Holocene (~ 6 ka) climate using the high-resolution Earth System Model EC-Earth3-Veg. The results show that coupled dynamic vegetation reproduces an apparent enhancement of the WAM, with the summer rainfall in the Sahel region increasing by 15% compared to simulations with a prescribed modern vegetation cover. Vegetation feedbacks enhance the warming of the Sahara region, deepens the Sahara Heat Low, results in increased rainfall and strengthens monsoonal flow across West Africa. However, the enhancement is still below what can be viewed in proxy reconstructions, highlighting the importance of investigating other processes, such as the interactive aerosol-albedo feedback.
Screening invitro antibacterial properties of Apis mellifera L. monofloral honey in Ethiopia
Authors: Tesfaye Ofijan 
Published: January 2023

Abstract
Background
Honey is a natural sweetener and viscous food which is synthesized from the nectar of flowering plants by bees. As a worldwide, it has been traditionally used for incurring different diseases. However, In recent times, the emergence of multi and extended drug-resistant human pathogens called for an urgent search for more effective sources of natural products to treat infectious diseases. The biological activity of honey primarily relies on its botanical and entomological origin. Hence, the objective of this study was to screen the in vitro antibacterial activity of honey based on botanical origin produced in Ethiopia.
Methods
Botanical origin was identified by the Melisopalynological analysis method. The inhibition zone was determined by agar well diffusion assay. Minimum inhibitory concentration was done by broth diffusion.
Result
Six different monofloral honey namely: Guizotia (75.3% pollen grain counted), Coffee arabica (68.6%), Vernonia (90.5%), Schefflera abyssinica (100%), Croton macrostachyus (64.4%) and Eucalyptus (100%) honey was harvested through December, February, February, April, May, and June respectively from the study area. All the monofloral honey inhibited the growth of all the bacterial strains even though the diameter of the inhibition zone varied. C. macrostachyus, Vernonia, Guizotia, and C. arabica were comparatively more whilst S. abyssinica was the least effective against all the tested bacterial strains. The grand mean inhibition zone ranged from 17.0 ± 1 mm by C. macrostachyus to 10.5 ± 1 mm by S. abyssinica against all the bacterial strains. Besides, the MIC of botanical honey type ranged from 11.7 ± 3.3% w/v by C. macrostachyus against S. aureus to 37.5 ± 1% w/v by S. abyssinica against P. aeruginosa.
Conclusion
The current result indicated that there is a disparity in antibacterial properties between monofloral honey. The more effective honey against the tested bacterial strain were those produced from the nectar of Ethiopian medicinal plants; based on literatures. Therefore, further in-vivo and in-vitro research would be expected from the concerned researchers on the association between the biological compounds present in each part of medicinal plants and honey samples.
Abnormalities in Hematological Profile in Solid Tumors/Non-Hematological Malignancies
Authors: KHAN QUYOOM BASHIR , BHARDWAJ SUBHASH , GUPTA RAJAT 
Published: January 2023

Abstract
Purpose: An abnormal hematological picture is the first presenting manifestation in solid tumors. The present study was carried out to evaluate various hematological abnormalities and correlate these parameters with the histological diagnosis in patients with solid tumors.
Methods: A total of 98 solid tumor patients were included in the study. Blood samples from all the cases were collected at the time of diagnosis for various hematological investigations.
Results: Out of these 98 patients, 54 were males and 44 were females. Anemia was found to be the most common haematological manifestation. We found 89 (90%) of the patients were anaemic, out of which 48 patients had mild anemia, 32 patients had moderate anemia and 9 patients had severe anemia. Thrombocytopenia was present in 33 (33.67%) out of 98 casesand was most common in breast cancer patients (18.18%) followed by stomach cancer patients (12.12%). Only 3 patients had thrombocytosis.Leucocytosis was noticed in 19 (19.38%) patients, out of which 15 (78.94%) patients had neutrophillia. Leucocytosis was found to be the most common in lung cancer patients (31.57%).
Conclusion: The present study showed a definite association of hematological manifestations viz. anemia, thrombocytopenia and leucocytosis with various non-hematological malignancies.
Effect of self-curing admixture and nature of the sand on the mechanical and microstructural properties of concrete in hot climate condition
Authors: Benouadah Abdelatif , Benammar Abdelhafid , Belkadi Ahmed Abderraouf , Maafi Nabil , Kessal Oussama 
Published: January 2023

Abstract
Hot climates predominate in many countries of the world. The average summer temperature in hot and desert areas is around 40 to 50°C. Concreting in these regions creates different difficulties in the fresh and hardened properties of the concretes due to the rapid loss of the mixing water by evaporation. In this study, the effects of hot climate and formulation parameters on the fresh and hardened properties of concrete in hot weather were investigated. Three types of sand (calcareous sand, silico-calcareous sand and siliceous sand), presence or not of the superplasticizer and the curing compound were used on fresh concrete surface. The hot weather concrete test parameters are the temperature of the dry materials and the water (50°C) at the time of mixing, thus the air velocity and humidity were set at 12 km/h and 10%, respectively. The properties tested were workability and compressive strength. in addition, the microstructural analysis of the concrete was examined by SEM and XRD. The results showed that the concrete containing calcareous sand revealed a higher compressive strength than the concrete with siliceous or silico-calcareous sands. However, a high fluidity was obtained by concrete based on siliceous or silico-calcareous sands. In hot weather, by using a curing compound and a superplasticizer, the compressive strength of concrete was increased especially for concrete with calcareous sand. This study helps concrete technologists determine the optimum formulation to achieve concrete with desired hot weather properties.