bluuebunny/crossref_metadata_2025_split huggingface dataset:
Central Corneal Thickness and Systemic Hypertension: The Colombian Glaucoma study.
Authors: rivera carlos , Ferreira Maria , Aristizabal juan , Muñoz Edgar , Seth Ankur 
Published: March 2023

Abstract
Objective: To determine the association between Systemic Hypertension and Central Corneal Thickness (CCT) in patients diagnosed with Systemic Hypertension (SH) and Diabetes Mellitus (DM) in six Colombian cities.
Methods: Patients with SH and DM in Colombia were studied in cross-sectional research. 2,067 people over 50 diagnosed with either SH or DM at the time of the study were included. Complete eye examinations included IOP measurement by Goldmann tonometry, and Central Corneal Thickness measurements.
Results: Among the 2067 participants, 1974 had Central Corneal Thickness measurement. CCT was normally distributed in this population, with a mean of 538.91 microns. A statistical difference in mean CCT between males (542.4 microns) and females (536.9 microns) (P< 0.001) was observed. Patients with SH had a statistical difference in CCT ( 537.98 microns ) compared with patients without SH ( 546.57 ) p <0.001. In multiple linear regression models adjusting for age, gender, ethnicity, IOP, and Body Mass Index, subjects with SH had central corneas 7.58 microns thinner than those without SH.
Conclusions: In this program-based study, we observed a strong correlation between Central Corneal Thickness and Systemic Hypertension. Considering the thinner corneas of these patients in terms of the glaucoma approach is essential.
Fault Determination Due to Sinkhole Array on the Kabudar-Ahang Plain of Hamedan, Iran
Authors: Ghobadi Mohammad Hossein , Tabarsa Alireza 
Published: March 2023

Abstract
Tectonic structures, especially faults, play an important role in the formation and spread of sinkholes and Karst. The main aim of this paper is to identify active faults in the north region of Hamedan province of Iran (Kabouda-Aahang, Razan and Famenine) through sinkhole array and chemical analysis of water. A lot of sinkholes have been created in the north of Hamedan. Most of these sinkholes are located in underground discharge areas near limestone of Oligo-Miocene age. The analysis of hydrogeological and hydrological conditions in the recent years showed that the conditions were suitable for sinkhole to form and develop. The presence of CO2 and H2S gases with a lot of amount in underground water, due to the rise of gases from hydrothermal and pneumatolytic resources, resulted in acidity of underground water and finally the acidic water rises to the enclosed aquifer through underground faults and fracture systems, leading to dissolution of limestones, and provide the ground for sinkhole formation. The sinkhole array in the region of the study showed that their formation and location are influenced by active faults in the region. As a result, a number of karst features such as sinkholes, caves, gully and karst spring have been formed in the north of Hamedan due to performance of active faults. Based on field visits, the review of aerial photo, chemical analysis of region water and dispersion of sinkholes, two faults with NW-SE, NE-SW trend were identified. Based on the evidence, it is assumed that formation and spread of sinkhole in the study area are controlled by active faults and vice versa the activity of faults may be determined by the formation and array of sinkholes and karst gully.
ARIQUELI Study I: Should quetiapine monotherapy be considered for any acute presentation of bipolar disorder?
Authors: Missio Giovani , Santos Carla Renata Garcia Rodrigues Dos , Moreira Marco Aurélio Muniz , Pimentel Fernando Cordeiro , Fernandes Fernando dos Santos , Demetrio Frederico Navas , Moreno Doris Hupfeld , Matos Francine Melo , Moreno Ricardo Alberto 
Published: March 2023

Abstract
Background: Bipolar disorder type I is a chronic disorder with a polymorphic and plastic presentation. Most clinical trials limit the evaluation of treatment to one of the poles of the acute phase. The ARIQUELI study aimed to evaluate the efficacy and tolerability of quetiapine monotherapy as a treatment for bipolar disorder overall, regardless of clinical presentation in the acute phase and in the maintenance phase.
Method: The ARIQUELI study was divided into two phases: Phase I, to investigate the treatment of bipolar disorder with quetiapine monotherapy, and Phase II, to compare two augmentation strategies in the treatment of quetiapine-refractory patients. Patients aged 18 to 40 years with type I bipolar disorder received quetiapine monotherapy between 300 to 800 mg for eight weeks regardless of clinical presentation. Responders were included in a maintenance phase of up to 22 months. The primary outcome was achievement and maintenance of response scores. Outcomes for Phase I were compared between the three clinical presentation groups in the acute phase (depression/mania/mixed).
Results: 105 patients were included, and although some differences in tolerability and depressive symptoms scores were observed, no difference between the groups was observed regarding primary outcome.
Conclusions: Quetiapine is equally effective in treating all forms of bipolar disorder I, with smaller differences in side effects and depressed patients showing a greater reduction in depressive symptoms.
Limitations: High prevalence of rapid cycling in the sample limits the comparison with other studies. Sample size was determined based on the results of the augmentation phase.
Burden of Illness in Rett Syndrome: Initial Evaluation of a Disorder-Specific Caregiver Survey
Authors: Kaufmann Walter , Percy Alan K. , Neul Jeffrey L. , Downs Jenny , Leonard Helen , Nues Paige , Sharma Girish D. , Bartolotta Theresa E. , Townend Gillian S. , Curfs Leopold M.G. , Mariotti Orietta , Buda Claude , O'Leary Heather M. , Vogel-Farley Vanessa , Barnes Katherine V. , Hammond Edward R. , Missling Christopher U. 
Published: March 2023

Abstract
Background
Rett syndrome (RTT) is a severe X-linked neurodevelopmental disorder associated with multiple neurologic impairments. Previous studies have shown challenges to affected individual and caregiver quality of life. However, instruments applied to quantify disease burden have not adequately captured the effect of symptoms on affected individuals and their families. Consequently, a collaboration of stakeholders in the USA, Europe, and Australia aimed to evaluate the Burden of Illness in RTT.
Methods
Based on literature reviews and qualitative interviews with parents of children and adults with RTT, caregiver and healthcare provider questionnaires were constructed to evaluate 21 problems often experienced with RTT (functional impairments, clinical manifestations, etc.), rated mainly with a 5-level Likert scale. These questionnaires were administered anonymously online to a sample of 756 caregivers (predominantly parents, classic RTT) and 112 clinicians. Descriptive statistics and chi-square tests were used in this initial analysis to identify (1) problems of high impact on affected individuals and caregivers, (2) the level of agreement between impact on individual and caregiver, and (3) the relationship between problem severity and impact.
Results
The most impactful problems were those related to the core features of RTT, namely communication and fine and gross motor impairments, irrespective of severity. Impairments tended to affect caregivers more than were perceived to affect individuals with RTT. In terms of severity, many problems have a disproportionate greater impact on affected individuals and their caregivers.
Conclusions
Our data demonstrate that even mild severity functional impairments and clinical manifestations can place a disproportionate burden on affected individuals and, particularly, their caregivers. Future analyses will examine the role of factors such as child age, MECP2 mutation, RTT clinical type and healthcare services in these burden of illness profiles.
Comparing Adult Smokers who Switched to JUUL vs Continuing Smokers: Biomarkers of Exposure and of Potential Harm and Respiratory Symptoms
Authors: Shiffman Saul , Oliveri Douglas R. , Goldenson Nicholas I. , Liang Qiwei , Black Ryan A. , Mishra Snigdha 
Published: March 2023

Abstract
Introduction: More real-world evidence on exposure to harmful and potentially harmful constituents (HPHCs) and on biological effects when cigarette smokers switch to e-cigarettes would be useful. Methods: This cross-sectional, observational study assessed adults who had smoked ≥ 10 cigarettes/day for ≥ 10 years, comparing 124 continuing cigarette smokers (Smokers) to 140 former smokers who switched to JUUL-brand e-cigarettes exclusively for ≥ 6 months (Switchers). Assessments included biomarkers of exposure (BOEs) to select HPHCs, biomarkers of potential harm (BOPHs) related to smoking-related diseases, and psychometric assessments of tobacco dependence and respiratory symptoms. Planned analyses compared geometric means, adjusted for covariates; exploratory analyses adjusted for additional covariates. Results: Nicotine was higher in Switchers, who were heavy users of JUUL. All other BOEs, including NNAL and HPMA3 (primary endpoints), were significantly lower in Switchers than Smokers. Most BOPHs (sICAM-1 [primary], and e.g., white blood cell count, MCP1, HbA1c) were significantly lower in Switchers than Smokers; HDL was significantly higher. Switchers reported significantly lower tobacco dependence and respiratory symptoms than Smokers. Conclusions: Compared to continuing smokers, smokers who switched to JUUL had substantially lower exposures to multiple HPHCs, favorable differences in markers of inflammation, endothelial function, oxidative stress, and cardiovascular risk, and less respiratory symptoms.
Floristic Composition, Structure, and Regeneration Status of Woody Plant Species in Hurubu Natural Forest,North Shewa, Oromia Region, Ethiopia
Authors: Gebirehiwot Hana Tamrat , Kedanu Alemayehu Abera , Guangel Abenezer Asmamaw , Adugna Megersa Tafese 
Published: March 2023

Abstract
Ethiopia harbours the Eastern Afromontane and Horn of Africa hotspots of biodiversity.The general objective of this study was to investigate the floristic composition and diversity of species, the structure and the regeneration status of the Hurubu natural forest. Three parallel transects was systematically laid across the forest with an interval of 200m in north to southt direction. Thirty sample quadrats of 20 m × 20 m was placed along transects at an interval of 100 m for mature trees and shrubs, while for the purpose of seedling and sapling inventory, four sub-quadrates of 1 m × 1 m was laid at each corner of the main quadrat. A total of 32 woody species representing 25 families was recorded consisting of trees and shrubs. The lower storey consisted of all woody plant species except Ekebergia capensis tree species. The middle storey consisted about 14.41% of the tree species while the upper storey involved only 2.35% of the total individual trees in the forest. The total basal area of woody plants in Hurubu forest was 90 m2 per ha. The three most important woody species with the highest IVI were Juniperus procera, Osyris quadripartite, & Myrsine Africana in decreasing order. The general regeneration status of the tree species of the study site was satisfactory at the community level showing a ‘fair’ regeneration status. Therefore, special conservation actions should be implemented for the poorly and not regenerating woody species of the forest.
Geovisualization: an effective approach to COVID-19 spatial analysis
Authors: Laudares Sandro , de Barros Adriano José , Martins Carlos Augusto Paiva da Silva , Libório Matheus Pereira 
Published: March 2023

Abstract
Geotechnologies were widely used during the pandemic period. The use of geotechnologies was not restricted to monitoring, controlling, and combating the pandemic. Research published in Brazil and worldwide has revealed the usefulness of geotechnologies for education, tourism, and waste management. Naturally, geotechnologies have also been widely used in the geovisualization of COVID-19. This research aims to offer a solution capable of providing public managers with current and easy-to-interpret information for monitoring, controlling, and developing effective public policies to combat the pandemic. The research presents two interactive dashboards that are easy to use, updatable in real-time, and offer multiple space-time analyses of COVID-19. These dashboards contribute to developing effective public policies to combat the COVID-19 pandemic and other epidemiological phenomena and cover the technological gap for geovisualization technologies that simultaneously analyze space and time. The developed dashboards have features that allow analyzing the space-time evolution of COVID-19, taking into account patient information. This is relevant news for coping with the pandemic, as age and comorbidity correlate with the chances of hospitalization and death from COVID-19. Another point of originality is the possibility of analyzing the evolution of the pandemic around specific spatial geometries. This functionality is highly relevant to ensure flexibility in planning policies to combat the pandemic for critical locations, such as, for example, around hospitals, shopping malls, avenues, highways, neighborhoods, and more vulnerable communities.
The impact of carbon emissions trading pilot on the carbon intensity of China's energy-intensive manufacturing industry
Authors: Luo Haiyan , Qu Xiaoe 
Published: March 2023

Abstract
Promoting carbon reduction in energy-intensive manufacturing is the only way for China to achieve the goal of "dual carbon". This paper calculates the carbon emission intensity of five energy-intensive manufacturing industries in 30 provinces of China, takes China's pilot carbon emissions trading policy as a quasi-natural experiment to construct a DID model, and systematically examines the impact of carbon emissions trading pilot on the carbon intensity of energy-intensive manufacturing industries and its mechanism. The results show that the carbon emissions trading pilot significantly reduces the carbon emission intensity of the energy-intensive manufacturing industry in the pilot provinces, and plays a positive role in promoting the low-carbon transition of the energy-intensive manufacturing industry. This conclusion is valid under various robustness tests. From the perspective of action mechanism, under the influence of carbon emissions trading pilot, the energy-intensive manufacturing industries in the pilot areas did not reduce carbon emissions by reducing production, but achieved carbon reduction targets by improving the level of green technology innovation. In addition, the impact of carbon emissions trading pilot on the carbon intensity of energy-intensive manufacturing industry is significantly heterogeneous due to different geographical locations and industry types. The impact of carbon trading policies on carbon reduction in energy-intensive manufacturing is more significant in eastern and central China, The pilot carbon trading policy mainly promoted the reduction of carbon emission intensity in three industries: chemical raw material and chemical product manufacturing, non-metallic mineral products industry, non-ferrous metal smelting and rolling processing industry. The conclusions of this study provide important policy implications for giving full play to the carbon reduction effect of carbon emissions trading policies and promoting the low-carbon transformation of energy-intensive manufacturing industries.
The expression and prognostic significance of circadian gene NR1D1/2 in patients with gastric cancer
Authors: Zheng Zhi Xue , Cai Xuan , Bi Jing Tao , Liu Ya Qi 
Published: March 2023

Abstract
Objective: The dysregulation of circadian rhythms is proved to be associated with the development of and may affect the treatment of tumors. However, the biological role of NR1D1/2 remains elusive in gastric cancer. We analyzed the effects of NR1D1/2 expression with occurrence and prognostic value for gastric cancer.
Methods: By using the online databases including ULCAN, KM plotter, STRING database and FunRich software, the effects of NR1D1/2 on the occurrence, clinical features and prognosis of gastric cancer were evaluated in gastric cancer.
Results: Based on the analyses of data obtained from online database, both the mRNA expression of NR1D1 and NR1D2 were higher in stomach carcinoma than in normal tissue (p<0.001). The level of NR1D1 expression was significantly increased in female patients, T, N, and Lauren classification in gastric cancer patients (p=0.017, 0.000, 0.014, 0.005, and 0.004), and the NR1D2 was significantly higher in male patients, HER2 status, tumor stage, T, Lauren classification, and differentiation in gastric cancer patients (p=0.000, 0.000, 0.000, 0.001, 0.000 and 0.000). The elevation of NR1D1/2 was significantly correlated with worse OS (overall survival), PPS (post-progression survival) and FP (First progression) in gastric cancer patients (p<0.001). Furthermore, we constructed protein-protein interaction networks of genes coexpressed with NR1D1 and NR1D2. FunRich analyses suggested that the NR1D1 and NR1D2 was possibly involved in BMAL1: CLOCK/NPAS2 activates gene expression and circadian clock pathway.
Conclusion: Our study suggests that NR1D1 and NR1D2 may be potential biomarkers for the diagnosis and prognosis of gastric cancer.
Screening Tools for Employment in Clinical Healthcare Delivery Systems: A Content Analysis
Authors: Colon Mina , Goodman Julia M. 
Published: March 2023

Abstract

Background
The relationship between work and health is complex and bidirectional, where work can have both health-harming and health-enhancing effects. Though employment is recognized as a social determinant of health, and clinical healthcare delivery systems are increasingly using screening tools to ask patients about social needs, little research has explored the extent to which employment-related social risk is captured in these screening tools. This study aimed to identify and characterize employment- and work-related questions in social risk screening tools that have been implemented in clinical healthcare delivery systems.
Methods
We conducted a qualitative content analysis of employment-related items in screening tools that have been implemented in clinical healthcare service delivery systems. Three content areas guided data extraction and analysis: Setting, Domain, and Level of Contextualization.
Results
Screening tools that asked employment-related questions were implemented in settings that were diverse in the populations served and the scope of care provided. The intent of employment-related items focused on four domains: Social Risk Factor, Social Need, Employment Exposure, and Legal Need. Most questions were found to have a low Level of Contextualization and were largely focused on identifying an individual’s employment status.
Conclusions
Several existing screening tools include measures of employment-related social risk, but these items do not have a clear purpose and range widely depending on the setting in which they are implemented. In order to maximize the utility of these tools, clinical healthcare delivery systems should carefully consider what domain(s) they aim to capture and how they anticipate using the screening tools to address social determinants of health.
Clinical value of PRC1 and DLGAP5 and immunosuppressive T cells overexpressing them in HCC based on transcriptome data
Authors: Yang Cheng-Lei , He Jia-Tai , Li Nan-Nan , Song Rui , Ni Hang-Hang , Huang Jun-Tao , Liu Guo-Qun , Wang Jun-Duo , Li Yuan-Kuan , Zhan Guo-Hua , Li Min-Jun , Zhao Jing-Fei , Zhang Jie , Xiang Bang-De 
Published: March 2023

Abstract
Purpose
Despite immune checkpoint inhibitor (ICI) has recently taken on an extremely important role in tumors, only a minority of hepatocellular carcinoma (HCC) patients are effective. The clinical value of PRC1 and DLGAP5 in HCC and its relationship with immune microenvironment have been rarely reported.
Methods
Key genes related to doubling time of HCC tumors were identified using WGCNA, and their expression was analyzed against our in-house RNA sequencing database, the Gene Expression Omnibus and the Cancer Genome Atlas database. We explored correlations between key genes and the immune microenvironment based on the TISCH and TIMER database, as well as clinicopathological characteristics and prognosis of HCC in patients at our center.
Results
WGCNA identified PRC1 and DLGAP5 as key genes in HCC. PRC1 and DLGAP5 were over-expressed in HCC tissues relative to normal tissues based on analysis of 2,154 patients and 1,344 controls. The genes gave respective areas under the summary receiver operator characteristic curve of 0.95 (95%CI 0.93–0.97) and 0.94 (95%CI 0.92–0.96). High expression of PRC1 and DLGAP5 positively correlated with tumor recurrence and microvascular invasion, was an independent risk factor for poor overall survival. PRC1 and DLGAP5 were co-expressed in proliferative T cells over-expressing immunosuppressive markers PDCD1, CTLA4, HAVCR2, LAG3 and TIGIT based on single-cell RNA-sequencing datasets.
Conclusions
PRC1 and DLGAP5 significantly upregulated in HCC are associated with poor prognosis and show strong diagnostic potential. PRC1 or DLGAP5 combined with CD8 T cell markers may serve as predictive biomarkers for the efficacy of ICI combination therapy.
Global maps of canopy photosynthesis of wine grape under changing climate
Authors: Murakami Keach , Nemoto Manabu 
Published: March 2023

Abstract
Climate change induces shifts in suitable areas for cultivation and phenology of grapevines, which regulate complex sunlight patterns within hedge rows and canopy photosynthetic gain. However, suitability assessments have focused on climate indices, such as growing season temperature, but have ignored canopy photosynthesis, despite its close connection to berry yield and wine quality. Here, we visualized global maps of the theoretical maxima of grapevine canopy photosynthetic gain during berry development under present and future climates scenarios using an integrated model of canopy light interception, leaf thermal balance, and photosynthetic processes. The high-latitude zone accommodated high-gain sites under future scenarios, characterized by shifted suitable areas and elevated atmospheric CO2 concentrations. By contrast, at some prestigious sites located at low latitudes, the projected leaf temperatures exceeded the optimal range for photosynthesis, resulting in reduced gain. Our results highlight a north-south gradient in canopy photosynthesis and support the decision-making of winemaking stakeholders.