bluuebunny/crossref_metadata_2025_split huggingface dataset:
La Soufrière volcano, St Vincent, eruption 2020–21: assessing unrest and eruptive states from limited volcano-seismic data
Authors: Latchman Joan L. , Aspinall Willy 
Published: April 2023

Abstract

Following a month of unrest in June–July 2019 and 3 months of effusive activity from late December 2020 to March 2021, La Soufrière volcano, St Vincent, transitioned to a 2-week period of explosions on 9 April 2021. During initial unrest, there was one working seismograph station on the volcano, providing the only information for tracking fluctuations in seismicity. Subsequently, full capability for locating volcanic earthquakes was achieved on 27 January 2021. Because events prior to this did not have reliable locations, unconventional data tracking approaches were adopted for assessing unrest evolution. Holistic inferences, suggested by combining these novel analyses with decades of knowledge of Lesser Antilles volcanoes, provided punctual evidential support for assessing the possibility that unrest could culminate in explosive activity. However, this case history is not offered as a paradigm for minimalist seismic monitoring at active volcanoes, notwithstanding that information gains were possible. This said, evaluations of seismic moment release, using event duration magnitudes as proxies for moment magnitudes, allowed the magma volume intruded or activated in the volcano to be estimated: 68 ± 14 × 10
6
m
3
dense rock equivalent (DRE) magma; this is a value remarkably similar to a geological estimate of total erupted volume (71 ± 14 × 10
6
m
3
DRE), with matching uncertainties.
Cancer Progress and Priorities: Gastric Cancer
Authors: Alagesan Priya , Goodwin Jessica C. , Garman Katherine S. , Epplein Meira 
Published: April 2023

AbstractGastric cancer, the fifth leading cause of cancer worldwide, is estimated to be responsible for approximately 1.4% of all new cancers and 1.8% of all cancer-related deaths in the United States. Despite declining incidence rates and improved survival rates, however, gastric cancer continues to disproportionately affect racial and ethnic minorities and individuals of lower socioeconomic status at higher rates than the general population. To improve outcomes globally and address disparities within the United States, continued improvements are needed in risk factor modification and biomarker development and to improve access to existing preventative measures such as genetic testing and H. pylori eradication testing, in addition to expanding upon current clinical guidelines for premalignant disease to address gaps in endoscopic surveillance and early detection.
Dor em pediatria
Authors: Okada Massako , Teixeira Manoel Jacobsen , Tengan Sérgio K. , Bezerra Simone Lopes , Ramos Carolina Anunciação 
Published: April 2023

Dor é comum em todas as faixas etárias pediátricas. É provável que se manifeste também durante a vida fetal. Osinstrumentos para a avaliação da dor em pediatria, fisiológicas, comportamentais, ou de auto-relatos devem ser adaptados a fase do desenvolvimento. As condições álgicas agudas mais prevalentes são relacionadas aos traumatismos de causa externa ou interna, as cefaléias e as síndromes dolorosas músculo-esqueléticas e viscerais são mais relacionadas à dor crônica ou recidivantes.
Tratamento da dor em pediatria
Authors: Okada Massako , Teixeira Manoel Jacobsen , Miyagi Karina Takesaki 
Published: April 2023

Várias evidências sugerem que além do aspecto humanístico, o tratamento da dor em pediatria previne numerosascomplicações de ordem, física e psicocomportamental. A avaliação adequada da condição dolorosa e a eliminação dos fatores causais biopsicossociais são atitudes necessárias para o tratamento da dor. Em concomitância com esta atitude, o uso de analgésicos antiinflamatórios não esteroidais, opióides e adjuvantes são recomendáveis para aplicação nas diferentes faixas etárias dos doentes pediátricos. Os procedimentos de medicina física e reabilitação e de medicina psicocomportamental são indicados especialmente durante a fase reabilitacional e como formas de treinamento das crianças para enfrentar as condições álgicas agudas e crônicas. Os procedimentos neuroanestésicos e neurocirúrgicos são indicados em condições especiais.
Wspomnienie o Profesor Irenie Kwileckiej (20 lutego 1925 – 11 lipca 2022)
Authors: Łuczak Arleta 
Published: April 2023

In Memoriam: Professor Irena Kwilecka (20 February 1925 – 11 July 2022)This article is an in memoriam to Professor Irena Kwilecka, a renowned scholar studying Old Polish Bible translations and sixteenth-century vocabularies. Professor Kwilecka worked at the Adam Mickiewicz University in Poznań (1953–1964) and the Institute of Slavic Studies, Polish Academy of Sciences (from 1964).Wspomnienie o Profesor Irenie Kwileckiej (20 lutego 1925 – 11 lipca 2022)Wspomnienie o Profesor Irenie Kwileckiej, wybitnej badaczce staropolskich przekładów Biblii i szesnastowiecznych wokabularzy. Pracowała na Uniwersytecie im. Adama Mickiewicza w Poznaniu (lata 1953–1964) i w Instytucie Slawistyki Polskiej Akademii Nauk (od 1964 roku).
Supportive Care Needs Among Head and Neck Cancer Patients Prior to Oncologic Treatment: A Prospective, Nested Cross-Sectional Qualitative Analysis
Authors: Day Andrew T. , Sood Anubha , Emmet Thomas R. , Eary Rebecca L. , Prestwood Courtney A. , Salley Jordan , Huffman Alexandra , Doenges Jacquelyn , Mayfield Arnold Elizabeth , Tiro Jasmin A. , Lee Simon Craddock 
Published: April 2023

Objectives: To qualitatively characterize pretreatment head and neck cancer (HNC) patients’ supportive care (SC) needs, attitudes toward SC, and barriers to SC utilization. Materials and Methods: A prospective, nested, bi-institutional, cross-sectional pilot study design was employed. Participants were sub-selected from a representative sample of 50 patients newly diagnosed with mucosal or salivary gland HNC or sarcoma of the head and neck. Eligibility criteria included reporting ≥2 unmet needs (according to the Supportive Care Needs Survey—Short Form 34) or clinically-significant distress (National Comprehensive Cancer Network Distress Thermometer score ≥4). Semi-structured interviews were performed prior to initiation of oncologic treatment. Audio-recorded interviews were transcribed and thematically analyzed using NVivo 12.0 (QSR Australia). Thematic findings and representative quotes were interpreted by the entire research team. Results: Twenty-seven patients were interviewed. One-third were treated at the county safety-net hospital and the remainder were treated at the university health system. An equal proportion of patients presented with oral cavity, oropharyngeal, and laryngeal or other tumors. Two significant findings were identified on semi-structured interviews. First, patients did not perceive the relevance of SC prior to treatment. Second, anxiety surrounding the HNC diagnosis and impending treatment dominated in the pretreatment phase. Conclusion: Improved HNC patient education about the relevance and importance of SC in the pretreatment setting is needed. Integration of social work or psychological services in HNC clinics is warranted to address patients’ cancer-related worry—a discrete, dominant pretreatment SC need.
The Human Rights Crisis in Mexico: Human Trafficking and Information Management
Authors: Veloz Adriana González , Pinto Luis Gabriel Arango 
Published: April 2023

An analysis of news items on human trafficking in Mexico published in digital newspaper portals and electronic versions of newspapers with national circulation concludes that the issue is of little interest to the media; the dissemination of information on the topic is limited and superficial and lacking in new data. The media reproduce vague perceptions of the phenomenon of human trafficking because they essentially reflect disagreements over the concepts, methodologies, and figures as handled by specialists. The reproduction of human rights violations in the journalistic items themselves (such as the mediatic display of the people involved in an event) is also noticeable. Un análisis de las noticias sobre la trata de personas en México publicadas en portales de periódicos digitales y versiones electrónicas de periódicos con circulación nacional concluye que el tema es de poco interés para los medios de comunicación. La difusión de información sobre el tema es limitada y superficial y carece de nuevos datos. Los medios de comunicación reproducen percepciones vagas en torno al fenómeno de la trata de personas porque esencialmente reflejan desacuerdos sobre los conceptos, metodologías y cifras manejadas por especialistas. La reproducción de violaciones a los derechos humanos en los propios artículos periodísticos (por ejemplo, la exhibición mediática de las personas involucradas en un evento) también es de notar.
Why Has Labor Productivity Slowed Down in the Era of Financialization?: Insights from the Post-Keynesians for the European Union Countries
Authors: Barradas Ricardo 
Published: April 2023

This article employs a panel data econometric approach in order to empirically ascertain the role of the phenomenon of financialization in the deceleration of labor productivity in the European Union countries from 1980 to 2019. During that time, the European Union countries suffered a huge structural transformation based on Reaganomics and Thatcherism and their financial systems have experienced strong liberalization and deregulation, which have contributed to poor evolution of labor productivity and have revived fears around a new “secular stagnation” in the era of financialization. Grounded in post-Keynesian literature, the slowdown of labor productivity in the majority of developed economies in the last decades cannot be separated from the phenomenon of financialization, which has occurred through four different channels, namely, weak economic performance, the decline in the labor income share, the increase in personal income inequality, and the strengthening of the degree of financialization and its corresponding harmful effects on innovation, research and development, technological progress, and productive investments performed by nonfinancial corporations. Our findings confirm that lagged labor productivity, economic performance, and labor income share have a positive impact on labor productivity in the European Union countries, while personal income inequality and the degree of financialization impact it negatively. Our findings also reveal that labor productivity in the European Union countries in the last decades would have grown more if there had been a stronger economic performance, a smaller decline (or even a rise) of the labor income share, a smaller increase (or even a decrease) of personal income inequality, and a weakening of the degree of financialization. JEL Classification: C23, E12, E24, and E44
Polymer/carbon nanotube nanocomposites as temperature sensing materials
Authors: Al Sawafi Suaad , Song Mo 
Published: April 2023

Multi-walled carbon nanotubes and high-density polyethylene (MWCNTs/HDPE) nanocomposite sheets with (1.0, 0.5, and 0.1) wt.% MWCNT were successfully prepared by coating the MWCNTs on the surface of the matrix particles (HDPE). The sample resistivities of the nanocomposites were investigated in relation to the temperature influence. Several findings could be drawn from these experiments: For instance, among all of the prepared MWCNT/HDPE nanocomposite sheets with (0.1, 0.5, and 1.0) wt. % MWCNT, the electrical resistivity of the 1.0 wt. % MWCNT/HDPE nanocomposite was 33.18 kΩ.m, demonstrating the best electrical conductivity. The resistivities of 0.1 wt. % and 0.5 wt. % samples were found to be 2594 and 372.23 kΩ.m respectively. Also, the measurements of temperature versus electrical conductivity revealed that the rise in temperature causes the electrical resistivity for the MWCNT/HDPE nanocomposites to increase due to the expansion of the distances between the conductive nanofillers (CNT), i.e., the sample resistivity increased under heating due to the thermal expansion of the polymer matrix. For example, the initial electrical resistivity for the 1.0 wt. % MWCNT/HDPE nanocomposite sheet decreased from 36.25 kΩ.m to 33.18 kΩ.m after the heat treatment. Besides, heat treatment could effectively improve the reproducibility of the MWCNT/HDPE nanocomposites. The reproducibility of the 1.0 wt. % MWCNT/HDPE nanocomposite was better than that of the 0.5 wt. % MWCNT/HDPE nanocomposite.
Mortality differences by race over 20 years in individuals with peripheral artery disease
Authors: Dicks Andrew B , Lakhter Vladimir , Elgendy Islam Y , Schainfeld Robert M , Mohapatra Abhisekh , Giri Jay , Weinberg Mitchell D , Weinberg Ido , Parmar Gaurav 
Published: April 2023

Introduction: Racial disparities exist in patients with peripheral artery disease (PAD), with Black individuals having worse PAD-specific outcomes. However, mortality risk in this population has been mixed. As such, we sought to evaluate all-cause mortality by race among individuals with PAD. Methods: We analyzed data from the National Health and Nutrition Examination Survey (NHANES). Baseline data were obtained from 1999 to 2004. Patients with PAD were grouped according to self-reported race. Multivariable Cox proportional hazards regression was performed to calculate adjusted hazard ratios (HR) by race. A separate analysis was performed to study the effect of burden of social determinants of health (SDoH) on all-cause mortality. Results: Of 647 individuals identified, 130 were Black and 323 were White. Black individuals had more premature PAD (30% vs 20%, p < 0.001) and a higher burden of SDoH compared to White individuals. Crude mortality rates were higher in Black individuals in the 40–49-year and 50–69-year age groups compared to White individuals (6.7% vs 6.1% and 8.8% vs 7.8%, respectively). Multivariable analysis demonstrated that Black individuals with both PAD and coronary artery disease (CAD) had a 30% higher hazard of death over 20 years compared to White individuals (HR = 1.3, 95% CI: 1.0–2.1). The cumulative burden of SDoH marginally (10–20%) increased the risk of all-cause mortality. Conclusions: In a nationally representative sample, Black individuals with PAD and CAD had higher rates of mortality compared to their White counterparts. These findings add further proof to the ongoing racial disparities among Black individuals with PAD and highlight the necessity to identify ways to mitigate these differences.
Management of hypertensive disorders of pregnancy in two Australian tertiary care maternity hospitals
Authors: Helou Amyna , Stewart Kay , George Johnson 
Published: April 2023

Background Hypertensive disorders of pregnancy (HDP) are common obstetric medical problems. Compliance with clinical guidelines and evidence from major trials has the potential to translate to significantly improve maternal and perinatal outcomes. The aims of this study were to prospectively review management of HDP in an Australian cohort in the context of the Society of Obstetric Medicine of Australian and New Zealand (SOMANZ) guidelines and current evidence in published literature regarding management controversies. Methods The management of 100 pregnant women with HDP and prescription for antihypertensive medication at two tertiary obstetric centres was prospectively reviewed in 2013. Compliance with SOMANZ guidelines, uptake of findings from the HYPITAT trial and the Control of Hypertension In Pregnancy Study (CHIPS) trial were assessed. Results Sixty-eight women had chronic hypertension, while 32 had gestational hypertension. Management of HDP was mostly consistent with current SOMANZ guidelines and evidence from CHIPS and HYPITAT. Conclusion Clinicians were practising according to the current SOMANZ guidelines, indicating vigilance on behalf of the treating team.
Hepatitis C Treatment in Persons Who Inject Drugs in a Medication Assisted Treatment Program: A Retrospective Review of an Integrated Model
Authors: Bobb Raymond , Malayala Srikrishna Varun , Ajayi Ebun , Wimbush Aliya , Bobb Alyssa 
Published: April 2023

Background: Hepatitis C virus (HCV) infection is common among persons who inject drugs (PWID), mostly due to needle sharing. The number of new cases in PWID are steadily increasing despite the availability of effective treatments. The objective of this model is to increase uptake and compliance with HCV treatment. We developed a model to treat HCV and opioid use disorder simultaneously in a methadone maintenance program. Methods: Patients were screened on site for HCV at admission and then annually. Once HCV was positive, the genotypes and fibrosis scores were identified. Patients were enrolled into the treatment program after obtaining written consent. Patients either self-administered the medications at home or utilized a directly observed treatment (DOT). The sustained virologic response (SVR) was tested at 12 weeks posttreatment. We conducted a retrospective review of patients who received treatment and reviewed the demographic data, co-infections, medication administration, and SVR results at the end of study period. Results: One hundred ninety patients were identified as Hepatitis C positive. 88.9% (169 patients) received HCV treatment during the study period. 62.7% (106 patients) were male and 37.3% were female (63 patients). 62.7% of them (106 patients) completed HCV treatment by the end of study period. Out of them, 96.2% (102 patients) achieved SVR. 68.9% (73 patients) utilized DOT for medication administration. Conclusions: Our model successfully treated HCV in our patient population, who are otherwise deprived of resources and access to health care. Replicating this model is a potential strategy to reduce the disease burden and break the transmission cycle of HCV.
Cyanidin-3-glucoside inhibits ferroptosis in renal tubular cells after ischemia/reperfusion injury via the AMPK pathway
Authors: Du Yi-Wei , Li Xiao-Kang , Wang Ting-Ting , Zhou Lu , Li Hui-Rong , Feng Lan , Ma Heng , Liu Hong-Bao 
Published: April 2023

Abstract
Background
Ferroptosis, which is characterized by lipid peroxidation and iron accumulation, is closely associated with the pathogenesis of acute renal injury (AKI). Cyanidin-3-glucoside (C3G), a typical flavonoid that has anti-inflammatory and antioxidant effects on ischemia‒reperfusion (I/R) injury, can induce AMP-activated protein kinase (AMPK) activation. This study aimed to show that C3G exerts nephroprotective effects against I/R-AKI related ferroptosis by regulating the AMPK pathway.

Methods
Hypoxia/reoxygenation (H/R)-induced HK-2 cells and I/R-AKI mice were treated with C3G with or without inhibiting AMPK. The level of intracellular free iron, the expression of the ferroptosis-related proteins acyl-CoA synthetase long chain family member 4 (ACSL4) and glutathione peroxidase 4 (GPX4), and the levels of the lipid peroxidation markers 4-hydroxynonenal (4-HNE), lipid reactive oxygen species (ROS) and malondialdehyde (MDA) were examined.

Results
We observed the inhibitory effect of C3G on ferroptosis in vitro and in vivo, which was characterized by the reversion of excessive intracellular free iron accumulation, a decrease in 4-HNE, lipid ROS, MDA levels and ACSL4 expression, and an increase in GPX4 expression and glutathione (GSH) levels. Notably, the inhibition of AMPK by CC significantly abrogated the nephroprotective effect of C3G on I/R-AKI models in vivo and in vitro.

Conclusion
Our results provide new insight into the nephroprotective effect of C3G on acute I/R-AKI by inhibiting ferroptosis by activating the AMPK pathway.
Integrating on-farm and genomic information improves the predictive ability of milk infrared prediction of blood indicators of metabolic disorders in dairy cows
Authors: Mota Lucio F. M. , Giannuzzi Diana , Pegolo Sara , Trevisi Erminio , Ajmone-Marsan Paolo , Cecchinato Alessio 
Published: April 2023

AbstractBackgroundBlood metabolic profiles can be used to assess metabolic disorders and to evaluate the health status of dairy cows. Given that these analyses are time-consuming, expensive, and stressful for the cows, there has been increased interest in Fourier transform infrared (FTIR) spectroscopy of milk samples as a rapid, cost-effective alternative for predicting metabolic disturbances. The integration of FTIR data with other layers of information such as genomic and on-farm data (days in milk (DIM) and parity) has been proposed to further enhance the predictive ability of statistical methods. Here, we developed a phenotype prediction approach for a panel of blood metabolites based on a combination of milk FTIR data, on-farm data, and genomic information recorded on 1150 Holstein cows, using BayesB and gradient boosting machine (GBM) models, with tenfold, batch-out and herd-out cross-validation (CV) scenarios.ResultsThe predictive ability of these approaches was measured by the coefficient of determination (R2). The results show that, compared to the model that includes only FTIR data, integration of both on-farm (DIM and parity) and genomic information with FTIR data improves the R2for blood metabolites across the three CV scenarios, especially with the herd-out CV: R2values ranged from 5.9 to 17.8% for BayesB, from 8.2 to 16.9% for GBM with the tenfold random CV, from 3.8 to 13.5% for BayesB and from 8.6 to 17.5% for GBM with the batch-out CV, and from 8.4 to 23.0% for BayesB and from 8.1 to 23.8% for GBM with the herd-out CV. Overall, with the model that includes the three sources of data, GBM was more accurate than BayesB with accuracies across the CV scenarios increasing by 7.1% for energy-related metabolites, 10.7% for liver function/hepatic damage, 9.6% for oxidative stress, 6.1% for inflammation/innate immunity, and 11.4% for mineral indicators.ConclusionsOur results show that, compared to using only milk FTIR data, a model integrating milk FTIR spectra with on-farm and genomic information improves the prediction of blood metabolic traits in Holstein cattle and that GBM is more accurate in predicting blood metabolites than BayesB, especially for the batch-out CV and herd-out CV scenarios.
Virulence of Mycobacterium intracellulare clinical strains in a mouse model of lung infection – role of neutrophilic inflammation in disease severity
Authors: Tateishi Yoshitaka , Ozeki Yuriko , Nishiyama Akihito , Miki Mari , Maekura Ryoji , Kida Hiroshi , Matsumoto Sohkichi 
Published: April 2023

Abstract
Background
Mycobacterium intracellulare is a major etiological agent of Mycobacterium avium-intracellulare pulmonary disease (MAC-PD). However, the characteristics of the virulence of M. intracellulare and the in vivo chemotherapeutic efficacy remain unclear. In this study, we examined the virulence of nine M. intracellulare strains with different clinical phenotypes and genotypes in C57BL/6 mice.

Results
We classified three types of virulence phenotypes (high, intermediate, and low) based on the kinetics of the bacterial load, histological lung inflammation, and neutrophilic infiltration. High virulence strains showed more severe neutrophilic infiltration in the lungs than intermediate and low virulence strains, with 6.27-fold and 11.0-fold differences of the average percentage of neutrophils in bronchoalveolar lavage fluid, respectively. In particular, the high virulence strain M.i.198 showed the highest mortality in mice, which corresponded to the rapid progression of clinical disease. In mice infected with the drug-sensitive high virulence strain M019, clarithromycin-containing chemotherapy showed the highest efficacy. Monotherapy with rifampicin exacerbated lung inflammation with increased lymphocytic and neutrophilic infiltration into the lungs.

Conclusions
The virulence phenotypes of clinical strains of M. intracellulare were diverse, with high virulence strains being associated with neutrophilic infiltration and disease progression in infected mice. These high virulence strains were proposed as a useful subject for in vivo chemotherapeutic experiments.