bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pre-filter analysis for retrieval of microphysical particle parameters: a quality-assurance method applied to 3 backscatter (β) +2 extinction (α) optical data taken with HSRL/Raman lidar
Authors: Kolgotin Alexei , Müller Detlef , Veselovskii Igor , Korenskiy Mikhail , Wang Xuan 
Published: May 2023

We analyze the solution space of 3β+2α optical data inferred from lidar measurements, i.e., backscatter coefficients at three wavelengths and extinction coefficients at two wavelengths. These optical data are governed by microphysical parameters that can be expressed in terms of particle size distribution, effective radius, and complex refractive index (CRI). In our analysis, we consider two scenarios of the solution space. First, it can be expressed in terms of monomodal particle size distributions represented either by fine modes or by coarse modes. Secondly, the particle size distributions contain a fine mode as well as a coarse mode. Consideration of both scenarios and different values of the effective radius and CRI allows us to find synthetic 3β+2α optical data and corresponding intensive parameters (IPs) such as lidar ratios, backscatter- and extinction-related Ångström exponents at the available measurement wavelengths. Based on interdependencies between synthetic IPs and various microphysical properties, the qualitative and quantitative criteria for the optical data quality-assurance tool are developed. We derive the conditions of smoothness, closeness, convergence, and stability of the solution space for the quantitative criteria to test the quality of the 3β+2α optical data. Our novel methodology, to the best of our knowledge, can be used not only for particles of spherical shape, but also for cases in which particles are irregularly shaped. Another strength of our methodology is that it also works for the case of a size-dependent and wavelength-dependent CRI. We show the potential of this methodology for a measurement case from the ORACLES campaign. Data were taken with NASA Langley’s airborne HSRL-2 instrument on September 24, 2016.
Impact of maternal protein restriction on Hypoxia-Inducible Factor (HIF) expression in male fetal kidney development
Authors: Gomes Julia Seva , Sene Leticia Barros , Lamana Gabriela Leme , Boer Patricia Aline , Gontijo José Antonio Rocha 
Published: May 2023

Background
Kidney developmental studies have demonstrated molecular pathway changes that may be related to decreased nephron numbers in the male 17 gestational days (17GD) low protein (LP) intake offspring compared to normal protein intake (NP) progeny. Here, we evaluated the HIF-1 and components of its pathway in the kidneys of 17-GD LP offspring to elucidate the molecular modulations during nephrogenesis.

Methods
Pregnant Wistar rats were allocated into two groups: NP (regular protein diet—17%) or LP (Low protein diet-6%). Taking into account miRNA transcriptome sequencing previous study (miRNA-Seq) in 17GD male offspring kidneys investigated predicted target genes and proteins related to the HIF-1 pathway by RT-qPCR and immunohistochemistry.

Results
In the present study, in male 17-GD LP offspring, an increased elF4, HSP90, p53, p300, NFκβ, and AT2 gene encoding compared to the NP progeny. Higher labeling of HIF-1α CAP cells in 17-DG LP offspring was associated with reduced elF4 and phosphorylated elF4 immunoreactivity in LP progeny CAP cells. In 17DG LP, the NFκβ and HSP90 immunoreactivity was enhanced, particularly in the CAP area.

Discussion and conclusion
The current study supported that the programmed reduced nephron number in the 17-DG LP offspring may be related to changes in the HIF-1α signaling pathway. Factors that facilitate the transposition of HIF-1α to progenitor renal cell nuclei, such as increased NOS, Ep300, and HSP90 expression, may have a crucial role in this regulatory system. Also, HIF-1α changes could be associated with reduced transcription of elF-4 and its respective signaling path.
The microbiome of an outpatient rehabilitation clinic and predictors of contamination: A pilot study
Authors: Brigando Gabriella , Sutton Casey , Uebelhor Olivia , Pitsoulakis Nicholas , Pytynia Matthew , Dillon Thomas , Elliott-Burke Teresa , Hubert Nathaniel , Martinez-Guryn Kristina , Bolch Charlotte , Ciancio Mae J. , Evans Christian C. 
Published: May 2023

Background
Understanding sources of microbial contamination in outpatient rehabilitation (REHAB) clinics is important to patients and healthcare providers.

Purpose
The purpose of this study was to characterize the microbiome of an outpatient REHAB clinic and examine relationships between clinic factors and contamination.

Methods
Forty commonly contacted surfaces in an outpatient REHAB clinic were observed for frequency of contact and swiped using environmental sample collection kits. Surfaces were categorized based on frequency of contact and cleaning and surface type. Total bacterial and fungal load was assessed using primer sets specific for the 16S rRNA and ITS genes, respectively. Bacterial samples were sequenced using the Illumina system and analyzed using Illumina-utils, Minimum Entropy Decomposition, QIIME2 (for alpha and beta diversity), LEfSe and ANCOM-BC for taxonomic differential abundance and ADONIS to test for differences in beta diversity (p<0.05).

Results
Porous surfaces had more bacterial DNA compared to non-porous surfaces (median non-porous = 0.0016ng/μL, 95%CI = 0.0077–0.00024ng/μL, N = 15; porous = 0.0084 ng/μL, 95%CI = 0.0046–0.019 ng/μL, N = 18. p = 0.0066,DNA. Samples clustered by type of surface with non-porous surfaces further differentiated by those contacted by hand versus foot. ADONIS two-way ANOVA showed that the interaction of porosity and contact frequency (but neither alone) had a significant effect on 16S communities (F = 1.7234, R2 = 0.0609, p = 0.032).

Discussion
Porosity of surfaces and the way they are contacted may play an underestimated, but important role in microbial contamination. Additional research involving a broader range of clinics is required to confirm results. Results suggest that surface and contact-specific cleaning and hygiene measures may be needed for optimal sanitization in outpatient REHAB clinics.
Comprehensive review of safety in Experimental Human Pneumococcal Challenge
Authors: Robinson Ryan E. , Myerscough Christopher , He Nengjie , Hill Helen , Shepherd Wendi A. , Gonzalez-Dias Patricia , Liatsikos Konstantinos , Latham Samuel , Fyles Fred , Doherty Klara , Hazenberg Phoebe , Shiham Fathimath , Mclenghan Daniella , Adler Hugh , Randles Vicki , Zaidi Seher , Hyder-Wright Angela , Mitsi Elena , Burhan Hassan , Morton Ben , Rylance Jamie , Lesosky Maia , Gordon Stephen B. , Collins Andrea M. , Ferreira Daniela M. 
Published: May 2023

Introduction
Experimental Human Pneumococcal Challenge (EHPC) involves the controlled exposure of adults to a specific antibiotic-sensitive Streptococcus pneumoniae serotype, to induce nasopharyngeal colonisation for the purpose of vaccine research. The aims are to review comprehensively the safety profile of EHPC, explore the association between pneumococcal colonisation and frequency of safety review and describe the medical intervention required to undertake such studies.

Methods
A single-centre review of all EHPC studies performed 2011–2021. All recorded serious adverse events (SAE) in eligible studies are reported. An unblinded meta-analysis of collated anonymised individual patient data from eligible EHPC studies was undertaken to assess the association between experimental pneumococcal colonisation and the frequency of safety events following inoculation.

Results
In 1416 individuals (median age 21, IQR 20–25), 1663 experimental pneumococcal inoculations were performed. No pneumococcal-related SAE have occurred. 214 safety review events were identified with 182 (12.85%) participants presenting with symptoms potentially in keeping with pneumococcal infection, predominantly in pneumococcal colonised individuals (colonised = 96/658, non-colonised = 86/1005, OR 1.81 (95% CI 1.28–2.56, P = <0.001). The majority were mild (pneumococcal group = 72.7% [120/165 reported symptoms], non-pneumococcal = 86.7% [124/143 reported symptoms]). 1.6% (23/1416) required antibiotics for safety.

Discussion
No SAEs were identified directly relating to pneumococcal inoculation. Safety review for symptoms was infrequent but occurred more in experimentally colonised participants. Most symptoms were mild and resolved with conservative management. A small minority required antibiotics, notably those serotype 3 inoculated.

Conclusion
Outpatient human pneumococcal challenge can be conducted safely with appropriate levels of safety monitoring procedures in place.
Sobre el Imperium de Augusto una vez más. Puesta al día de una cuestión centenaria
Authors: López Gómez Helena 
Published: May 2023

El presente trabajo pretende ser una nueva contribución y puesta al día sobre una interesante cuestión que ha intrigado a la historiografía durante siglos. Las incógnitas sobre la naturaleza del régimen instaurado por Augusto una vez se hizo con el poder en solitario han atraído la atención de los historiadores desde el siglo XIX (Mommsen, 1876-1888; Puchta, 1882; Kromayer, 1888; Pellham, 1888; Abele, 1891; Gardthausen, 1896; Bonfante, 1902; Betti, 1915; Dessau, 1924; Von Premerstein, 1937, y un largo etc.). Tradicionalmente se ha considerado que la posición imperial estaría constituida por una serie de elementos individuales que, en conjunto, darían unos grandes poderes a su poseedor, sin por ello crear una nueva institución como tal. Entre los principales poderes detentados por Augusto y sus sucesores se han señalado especialmente el imperium, el control de una serie de provincias y la tribunicia potestas. En este trabajo la atención se dirigirá hacia el primero de estos elementos, pues, dentro del amplio tema, un lugar central lo ocupa la definición de las características del imperium del primer princeps. La confusión en los acontecimientos que siguieron al 31 a. C. y las acciones y disposiciones de Augusto no ayudan a clarificar los hechos, siendo extremadamente complicado atribuir intervenciones imperiales a un poder concreto. Mi intención es exponer los acontecimientos que siguieron a la toma del poder en solitario explicando, a través de las distintas percepciones de los principales autores expertos sobre la materia, las interpretaciones dadas a la conformación del imperium de los príncipes. Aunque mi análisis sea profundamente historiográfico, ello no excluye que también se intente aportar una visión particular sobre el tema a tratar, lo que contribuirá a mantener vivo este tema centenario que está lejos de ser concluido.
GLUE VALUE AT RISK UNTUK MENGUKUR RISIKO PADA PORTOFOLIO OPTIMAL DENGAN METODE MULTI INDEX MODEL
Authors: Khofifah Nur , Rusgiyono Agus , Maruddani Di Asih I 
Published: May 2023

Creating a portfolio is one method of reducing risk. One of the best portfolio decisions is made by Multi Index Model. Multi Index Model is a method that makes use of multiple variables that impact stock returns. Before making an investment, risk measurement must be considered. Calculation of risk on a portfolio will be more accurate if it is calculated using Glue Value at Risk, because it satisfies the property of subadditivity, which is one of the coherence properties of a risk measure that reflects the idea that risk can reduce by diversification. The stocks used in this study are 4 stocks that are members of SRI-KEHATI stock group in the period January 2017 – December 2021. The factors used are Composite Stock Price Index (JCI), and Rupiah to USD exchange rate. According to the study's findings, the best portfolio consist of four stocks: BBRI (Bank Rakyat Indonesia Tbk.) (17.82%), KLBF (Kalbe Farma Tbk.) (56.66%), UNTR (United Tractors Tbk.) (24.13%), and WIKA (Wijaya Karya Tbk.) (1.39%). The confidence levels of and , the distortion function height is and are used, the GlueVaR value for the stock portfolio is 10.476%.
ANALISIS INDEKS HARGA SAHAM GABUNGAN DAN FAKTOR PENGARUHNYA MENGGUNAKAN PEMODELAN REGRESI SEMIPARAMETRIK KERNEL DILENGKAPI GUI-R
Authors: Kahar Arnisa Melani , Suparti Suparti , Hakim Arief Rachman 
Published: May 2023

Composite Stock Price Index (IDX) shows the movement of stock prices used by investors to determine their investment strategy. IDX movement is influenced by macroeconomic factors such as money supply and inflation, so regression analysis is used to determine the relationship between the variables. Based on the scatterplot, money supply is known as a parametric predictor variable as it has a linier line patterned scatterplot and inflation is a nonparametric predictor variable as it has a random patterned scatterplot, so semiparametric regression modelling is used for the analysis. Kernel regression was chosen to analyze the nonparametric component based on the random patterned scatterplot of inflation. This study aims to obtain the results of semiparametric kernel regression modelling analysis and to create a GUI to be applied to the analysis as a development of previous similar studies that still done based on CLI. This study uses monthly data from January 2013 to December 2020 with the proportion of in sample and out sample data distribution 87,5%:12,5%. Based on the smallest MSE value as the best model criteria, semiparametric regression model with triangle kernel function is the best model obtained with optimal bandwidth=3.24, which means the model is strong and which means that the forecasting results are very accurate. GUI has been created according to the needs of the modelling analysis implementation.
Aristotle’s Logic of Biological Diversity
Authors: Carbone Andrea Libero 
Published: May 2023

AbstractAristotle’s biology is based on his method of division of animal kinds by multiple differentiae. This results in complex clusters of non-subordinate terms, between which Aristotle seeks to establish universal correlations. The form of these, however, does not correspond to that prescribed by his theory of syllogism. Mereological relations between terms are not linear and quantification is far more complex than the distinction between universal and particular propositions. Thus the axiomatisation of Aristotle’s biology requires a tool designed for analysing such complex universal correlations into valid syllogistic premises. Prosleptic-like premises turn out to be the solution outlined by Aristotle. They make it possible to handle both the logic of consequence which translates from and into mereological relations between term clusters, and the complex quantification required by division based on multiple differentiæ, through the instantiation of a variable ideally consisting of indivisible groups of animals.
Large-scale green hydrogen production using alkaline water electrolysis based on seasonal solar radiation
Authors: Hassan Qusay , Sameen Aws Zuhair , Salman Hayder M. , Jaszczur Marek 
Published: May 2023

Abstract
The research study provides a techno-economic analysis for the green hydrogen generation based solar radiation data for both the single and hybrid alkaline water electrolyzer and energy storage system systems. In addition, a carbon footprint study is conducted to estimate the developed system carbon dioxide emissions. The optimal size of the alkaline water electrolyzer and energy storage system is determined by a genetic algorithm that takes into account a carbon tax on carbon emissions. Based on itemized cost estimating findings, unit hydrogen production costs for a single system and a hybrid system were $6.88/kg and $8.32/kg respectively. Furthermore, capital cost it has been found as a key element in determining the optimal scale of the alkaline water electrolyzer and energy storage system, which are essential for minimizing the unit hydrogen production cost. Lastly, an effort to minimize the capital cost of producing green hydrogen is required when the rising trend of the carbon dioxide tax is taken into account.
An RRAM-based building block for reprogrammable non-uniform sampling ADCs
Authors: Vishwakarma Abhinav , Fritscher Markus , Hagelauer Amelie , Reichenbach Marc 
Published: May 2023

AbstractRRAM devices have recently seen wide-spread adoption into applications such as neural networks and storage elements since their inherent non-volatility and multi-bit-capability renders them a possible candidate for mitigating the von-Neumann bottleneck. Researchers often face difficulties when developing edge devices, since dealing with sensors detecting parameters such as humidity or temperature often requires large and power-consuming ADCs. We propose a possible mitigation, namely using a RRAM device in combination with a comparator circuit to form a basic block for threshold detection. This can be expanded towards programmable non-uniform sampling ADCs, significantly reducing both area and power consumption since significantly smaller bit-resolutions are required. We demonstrate how a comparator circuit designed in 130 nm technology can be reprogrammed by programming the incorporated RRAM device. Our proposed building block consumes 83 µW.
Sequential positions and interactional functions of negative epistemic constructions in Japanese conversation
Authors: Endo Tomoko 
Published: May 2023

Abstract
In this study, we adopted the methodology of conversation analysis and interactional linguistics to investigate the use of shiranai and wakannai ‘I don’t know’ in data from (the Corpus of Everyday Japanese Conversation), a corpus of naturally occurring conversations. The quantitative and qualitative analyses of the sequential positions and the interactional functions of these two expressions revealed that shiranai is often used as a response to a question that explicitly requests knowledge status. Shiranai is also used in response to informing, soliciting more talk from the interlocutor. On the other hand, wakannai is more often used as a response to a question that requests information. Used with prosodic features such as elongation and laughter, both shiranai and wakannai sometimes convey the speaker’s affective stance towards the lack of knowledge. Furthermore, wakannai can be used as a discourse marker to mark the speaker’s low degree of commitment, sometimes working as a sequence-closing device.
Kedo-ending turn format as a formula for a problem statement with a deontic implication
Authors: Yokomori Daisuke 
Published: May 2023

AbstractIn many languages, some turn formats are highly fixed and closely associated with specific interactional contexts, and thus function as formulas for particular actions. In Japanese, one of the recurring turn formats for referring to a problem found in the surrounding situation or other’s conduct is a clause ending with the contrastive particlekedo‘but’. Based on close examination of examples from naturally-occurring conversations using the analytic framework of Interactional Linguistics, this article illustrates that the format withkedois used to assign a deontic authority concerning an observed problem to the recipient and thereby leaving to the recipient a decision about how the problem should be dealt with and by whom. This shows a clear contrast with the turn format ending withyo, which is used to inform the recipients of what the speaker knows as a problem, and thereby to ask the hearers to register it.
Formulaicity of fictional quotativega ittetaand its functions in Japanese social media posts
Authors: Tsuchiya Tomoyuki 
Published: May 2023

AbstractRelatively longer formulaic sequences are often subject to syntactic, lexical, and semantic variability, and this variability presumably connects to the development of constructional schemata and to language creativity. The present paper focuses on the formulaicity, variation, and communicative effects of the quotative phraseX ga itteta‘X was saying’ in Japanese social media posts, whose situation would become fictional or less factual depending on the nature of the subjectX. Twitter data suggest thatX ga ittetawith certain subjects (e.g., high school girls, cats, moms; see below) is more conventionalized compared to the counterpartY-tte itteta‘was saying that Y’, where Y is a quoted statement, with the same subject. Additionally, the construction accepts variation of surrounding elements to raise its fictional level. In Japanese online platforms, the schemaX ga ittetaand its formulaic instances possibly distance the quoter from the quoted statement and avoid arguments and criticisms.
Commas as a constructional resource: the use of a comma in a formulaic expression in Japanese social media texts
Authors: Horiuchi Fumino , Nakayama Toshihide 
Published: May 2023

AbstractThis paper examines the use of punctuation in Japanese in order to investigate its role in formulaic expressions. Specifically, we will study the use of a comma before the copula complexdakedoneat the end of an utterance. Typically, punctuation is considered a matter of style in written representations and is generally not included in studies about the structure of formulaic expressions. However, in a corpus-based study on language use on social media (e.g., blogs, Twitter, online forums), we found that this comma is frequently used for a distinct pragmatic effect. The patterns of use, both structural and functional, are observed to be regular and predictable, enough to suggest that the comma is part of a fixed formal complex that has a unique meaning, i.e., a construction. This in turn suggests that commas, even though they are punctuation, can be a formal resource that constitutes part of a formulaic expression.
Gluconic acid: strategies for microbial production using organic waste and applications
Authors: Raj Mayank , Singh Manoj , Kumar Vikas , Devi Tamanna , Upadhyay Sushil Kumar , Mishra Prabhakar , Kumar Sunil , Yadav Mukesh , Sehrawat Nirmala , Kumari Mamta 
Published: May 2023

Abstract
Gluconic acid is one of the most important natural acids which are moderately generated from glucose via a straightforward oxidation reaction process. Through the use of microorganisms like Gluconobacter (bacteria) and fungi, the reaction is facilitated through various enzymes such enzyme glucose oxidase and glucose dehydrogenase. The typical widespread, fermentation procedure is characterized by the use of Aspergillus niger (fungi). The primary gluconic acid derivatives, such as sodium gluconate, are widely used in the agricultural and food industries. Gluconic acid has several uses in the pharmaceutical, food, beverage, textile, cement, metal chelating agent, leather, and dairy sectors. Commercial production of gluconic acid made by fungi is well-established. Therefore, fermentation procedures and effective microorganisms are employed to produce gluconic acid with a higher yield and higher quality. These processes are also more economical and effectively convert inexpensive substrates into carbon sources. Production of gluconic acid has been reported with corn starch, grapes must, banana must, egg shells, and potato pulp using both solid state and submerged fermentation. This article provides a thorough analytical analysis for the gluconic acid production through microbial fermentation and its uses in agriculture and food. Additionally, this contemporary paper thoroughly examines the literature from recent years on the growth of gluconic acid production for the global market.