bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vitamin C and vitamin D3 alleviate metabolic-associated fatty liver disease by regulating the gut microbiota and bile acid metabolism via the gut-liver axis
Authors: Chen Qingling , Zhao Lili , Mei Ling , Zhao Xiaotong , Han Ping , Liu Jie , Meng Chao , Li Ruifang , Zhong Rui , Wang Kai , Li Jia 
Published: April 2023

Background: Previous studies have demonstrated that both vitamin C (VC) and vitamin D3 (VD3) have therapeutic potential against metabolic disorders, including obesity, diabetes, and metabolic-associated fatty liver disease (MAFLD). However, it is unclear whether VC supplementation is associated with improving the intestinal flora and regulating the metabolism of bile acids via the gut-liver axis in MAFLD. There is still no direct comparison or combination study of these two vitamins on these effects.Methods: In this study, we employed biochemical, histological, 16S rDNA-based microbiological, non-targeted liver metabolomic, and quantitative real-time polymerase chain reaction analyses to explore the intervening effect and mechanism of VC and VD3 on MAFLD by using a high-fat diet (HFD)-induced obese mouse model.Results: Treatment of mice with VC and VD3 efficiently reversed the characteristics of MAFLD, such as obesity, dyslipidemia, insulin resistance, hepatic steatosis, and inflammation. VC and VD3 showed similar beneficial effects as mentioned above in HFD-induced obese mice. Interestingly, VC and VD3 reshaped the gut microbiota composition; improved gut barrier integrity; ameliorated oxidative stress and inflammation in the gut-liver axis; inhibited bile acid salt reflux-related ASBT; activated bile acid synthesis-related CYP7A1, bile acid receptor FXR, and bile acid transportation-related BSEP in the gut-liver axis; and improved bile secretion, thus decreasing the expression of FAS in the liver and efficiently ameliorating MAFLD in mice.Conclusion: Together, the results indicate that the anti-MAFLD activities of VC and VD3 are linked to improved gut-liver interactions via regulation of the gut microbiota and bile acid metabolism, and they may therefore prove useful in treating MAFLD clinically.
Physiological effects of regular CrossFit® training and the impact of the COVID-19 pandemic—A systematic review
Authors: Meier Nicole , Schlie Jennifer , Schmidt Annette 
Published: April 2023

CrossFit®is a functional fitness training program known for its day-to-day varying “Workouts of the Day” (WOD). In accordance with the ‘CrossFit®Level 1 Training Guide’, regular CrossFit® training sessions consist of Warm-up, Mobility, Skill/Power training, WOD, and Cool-down. Despite the fast-growing and widespread popularity, data on the practical implementation of the training program based on scientific evidence are rare. Therefore, the purpose of this study is to systematically review the existing literature on the physiological effects of regular CrossFit®training in full extent instead of stand-alone WODs and to examine the impact of the COVID-19 pandemic on the training behavior of CrossFit®athletes. A systematic search was conducted following the PRISMA guidelines in April 2022 and updated in July 2022 using the following databases: PubMed, SPORTDiscus, Scopus, and Web of Science. Using the keyword “CrossFit”, 1,264 records were found. Based on the eligibility criteria, 12 studies are included and separated by topics: acute-short term physiological response (n = 8), and impact of the COVID-19 pandemic (n = 4). The results show that studies of regular training sessions were rarely conducted and contradicted the existing knowledge of the physiological demands [e.g., heart rate (HR)] of CrossFit®. In detail, included studies demonstrate that training sessions last 30–60 min and provide a progressive increase in cardiovascular load up to maximal effort activity (&gt;90% HRmax), differing from stand-alone WODs exclusively at high-intensity. Also, scarce research exists on COVID-19-pandemic-induced effects on training behavior, and studies are of moderate to low quality. There is still a lack of comprehensive analyses on the acute physiological effects of regular training sessions and the consequences of the COVID-19 pandemic in the scientific literature. Moreover, the inconsistent terminology used in CrossFit®research complicates generalized conclusions. Therefore, future research on the training methodology of CrossFit®needs to overcome terminological inequalities and examine scientifically the implementation of the concept by considering regular training sessions under practical settings.
Post-anthesis supplementary irrigation improves grain yield and nutritional quality of drip-irrigated rice (Oryza sativa L.)
Authors: Wang Xiangbin , Zhang Xinjiang , Liu Linghui , Liu Xiaowu , Feng Guorui , Wang Juan , Yin Yong-an , Wei Changzhou 
Published: April 2023

IntroductionApproximately 50% of irrigation water is saved during drip-irrigation of rice, which has tremendous potential for water-saving agriculture, particularly in areas where water resources are scarce. However, the grain yield and quality of drip-irrigated rice are adversely affected.MethodsIn this study, we investigated the effects of different irrigation strategies on the grain yield and quality of drip-irrigated rice using field experiments. Four irrigation treatments were studied: whole growing season flooding (FI), whole growing season normal drip irrigation (DI, soil relative moisture (RSM) was maintained in the range of 90-100%), pre-anthesis drip irrigation and post-anthesis water stress (SAF, the RSM was maintained in the range of 80-90% after anthesis), pre-anthesis drip irrigation, and post-anthesis flooding (FAF).ResultsThe results showed that grain yield, harvest index, seed setting rate and 1000 grain weight in DI and SAF were significantly lower than in FI and FAF. These parameters were not significantly different between FI and FAF but were significantly greater in DI than in SAF. Compared with FI and FAF, the source capacity, source activity time, and sink activity of DI and SAF decreased, and the sink-source difference increased. The sink-source difference had a significant negative correlation with rice yield and 1000 grain weight. The activities of ADP-glucose pyrophosphorylase, starch branching enzyme, and amylopectin content in grains in the middle panicles of FAF were significantly higher than those of DI and SAF. SAF resulted in increased amylose/amylopectin ratio and total protein content in grains but decreased proportion of glutenin in total protein. Irrigation after anthesis of drip-irrigated rice narrowed the difference between sink sources in rice plants, increased the grain yield and harvest index by 29.2% and 11%, respectively, compared to DI, increased water productivity by 19% compared to FI, and improved the grain quality of drip-irrigated rice.DiscussionThis study highlights that post-anthesis sufficient irrigation of drip-irrigated rice plays a positive role in maintaining the source-sink balance. This study serves as a foundation for the development of more effective rice farming methods that conserve water, while increasing the grain yield and quality of drip-irrigated rice.
The framework for systematic reviews on psychological risk factors for persistent somatic symptoms and related syndromes and disorders (PSY-PSS)
Authors: Hüsing Paul , Smakowski Abigail , Löwe Bernd , Kleinstäuber Maria , Toussaint Anne , Shedden-Mora Meike C. 
Published: April 2023

IntroductionNumerous psychological factors are believed to play a pivotal role in the development and maintenance of persistent somatic symptoms (PSS) in all fields of medicine. However, very few of these factors have been empirically investigated in relation to PSS. The aim of this study is firstly to propose a framework and define search terms for systematic reviews on the empirical evidence and diagnostic value of psychological risk factors for PSS and PSS-related outcomes (PSY-PSS). Secondly, the application of the framework is illustrated using the example of a systematic review on the relevance of psychological factors in somatic symptom disorders (SSD; DSM-5) and bodily distress disorders (BDD; ICD-11).MethodsFollowing a narrative review approach, two comprehensive lists of search terms to identify studies in (1) relevant patient groups with PSS and (2) relevant psychological factors were generated by reviewing the current literature and employing an iterative process of internal revision and external expert feedback.ResultsWe identified 83 relevant symptoms, syndromes and disorders for which we defined a total of 322 search terms (list 1). We further comprised 120 psychological factors into 42 subcategories and 7 main categories (list 2). The introduced lists can be combined to conduct systematic reviews on one or more specific psychological factors in combination with any symptom, syndrome or disorder of interest. A protocol of the application of this framework in a systematic review and meta-analysis on psychological etiological factors of SSD and BDD is presented following the PRISMA guidelines.DiscussionThis framework will help to gather systematic evidence on psychological factors in order to improve the understanding of the etiology of PSS, to refine future diagnostic conceptualizations of PPS, and to develop optimized mechanism-based interventions for individuals with PPS and related syndromes and disorders.
Comparison of two frailty indices in predicting life-threatening morbidity and mortality among older patients undergoing elective high-risk abdominal surgery
Authors: Li Chun-Qing , Kong Hao , Xu Zhen-Zhen , Ma Jia-Hui , Li Xue-Ying 
Published: April 2023

BackgroundFrailty predicts an increased risk of postoperative morbidity and mortality. Comparison of the predictive performance between two deficit accumulation models of frailty, the modified frailty index (mFI) and the revised-Risk Analysis Index (RAI-rev), is poorly understood. This study compared the predictive abilities of the above two frailty indices in predicting life-threatening morbidity and mortality among older patients following elective high-risk abdominal surgery.MethodsThis retrospective cohort study extracted perioperative data of older patients (age ≥65 years) undergoing elective high-risk abdominal surgery at a single institution between January 2018 and December 2020. Preoperative frailty was screened by mFI and RAI-rev scoring systems. The primary outcome was the composite of postoperative life-threatening morbidity and mortality during hospitalization. Multivariable logistic regression analyses were performed to investigate the association of the two frailty indices with the primary outcome. Receiver-operating characteristic (ROC) curve was employed to test the predictive performances of the two frailty instruments in predicting the composite primary outcome. The difference between the area under the curves (AUCs) was assessed by DeLong’s test.Results1,132 older patients (mean age, 73.4 ± 6.2 years; 63.9% male) were included. Of these, 107 (9.5%) developed postoperative life-threatening morbidity and mortality. In multivariable logistic regression analyses, rising continuous frailty scores (mFI: adjusted OR 1.319 per 0.09-point increase in score, 95% CI 1.151–1.511, p &lt; 0.001; RAI-rev: adjusted OR 1.052 per 1-point increase in score, 95% CI 1.018–1.087, p = 0.002) as well as dichotomized frailty measures (mFI ≥0.27: adjusted OR 2.059, 95% CI 1.328–3.193, p = 0.001; RAI-rev ≥45: adjusted OR 1.862, 95% CI 1.188–2.919, p = 0.007) were associated with increased odds of the primary outcome separately. ROC curve analysis showed that the discrimination of mFI and RAI-rev scores for the life-threatening morbidity and mortality was poor and comparable (AUC: 0.598 [95% CI 0.569–0.627] vs. 0.613 [95% CI 0.583–0.641]; DeLong’s test: Z = 0.375, p = 0.7075).ConclusionHigh mFI and RAI-rev scores were associated with an increased risk of life-threatening morbidity and mortality in older patients undergoing elective high-risk abdominal surgery. However, both frailty indices displayed poor discrimination for postoperative life-threatening morbidity and mortality.
The effect of group support psychotherapy on adherence to anti-retroviral therapy and viral suppression among HIV positive young people: Study protocol for a pilot randomized controlled trial
Authors: Nakimuli-Mpungu Etheldreda , Wamala Kizito , Nalugya Joyce Sserunjoji , Nakanyike Caroline , Iya Jane , Bakeera Kitaka Sabrina , Diana Namuli Justine , Akimana Benedict , Nachega Jean B. , Mills Edward J. , Seggane Musisi 
Published: April 2023

BackgroundSeveral studies have demonstrated an association between psychological risk factors and HIV disease progression. However, there is limited information on the use of psychological interventions to improve HIV treatment outcomes in young people living with HIV.ObjectiveThis pilot trial aims to evaluate the feasibility, acceptability and preliminary effectiveness of group support psychotherapy in improving adherence to anti-retroviral therapy and viral suppression in young people living with HIV in Uganda.MethodsWe recruited 120 young people with HIV, aged 10–18 years, who had non-viral suppression 6 months after initiating first-line anti-retroviral therapy (ART) from community based HIV clinics in Kitgum district, northern Uganda. Participants were randomly assigned to receive GSP plus IAC (N = 60) or IAC alone (N = 60). Primary outcomes will be indicators of feasibility and acceptability as well as preliminary effectiveness of GSP in improving ART adherence and viral suppression analysed by intention to treat using cluster-adjusted t tests and permutation tests. Secondary outcomes will be measures of depression, anxiety and cost-effectiveness.ResultsThe trial has been approved by the Makerere College of Health Sciences School of Health Sciences Research Ethics Committee, and the Uganda National Council of Science and Technology. Recruitment began in June 2021 and 120 young people living with HIV with their adult caregivers have been recruited to the trial. An analysis of baseline and 6-month data is in progress. The results of this trial will not only be presented at national and international conferences but also submitted for publication in peer-reviewed journals and as a report to the funding agencies.ConclusionsThis pilot trial will provide critical evidence to support the ongoing mental health integration into routine HIV care in Uganda.Trial RegistrationPan African Clinical Trials Registry (PACTR): 202006601935462
Amniotic Fluid Mesenchymal Stromal Cells Derived from Fetuses with Isolated Cardiac Defects Exhibit Decreased Proliferation and Cardiomyogenic Potential
Authors: Jain Manali , Singh Neeta , Fatima Raunaq , Nachanekar Aditya , Pradhan Mandakini , Nityanand Soniya , Chaturvedi Chandra Prakash 
Published: April 2023

Amniotic fluid mesenchymal stromal cells (AF-MSCs) represent an autologous cell source to ameliorate congenital heart defects (CHDs) in children. The AF-MSCs, having cardiomyogenic potential and being of fetal origin, may reflect the physiological and pathological changes in the fetal heart during embryogenesis. Hence, the study of defects in the functional properties of these stem cells during fetal heart development will help obtain a better understanding of the cause of neonatal CHDs. Therefore, in the present study, we compared the proliferative and cardiomyogenic potential of AF-MSCs derived from ICHD fetuses (ICHD AF-MSCs) with AF-MSCs from structurally normal fetuses (normal AF-MSCs). Compared to normal AF-MSCs, the ICHD AF-MSCs showed comparable immunophenotypic MSC marker expression and adipogenic and chondrogenic differentiation potential, with decreased proliferation, higher senescence, increased expression of DNA-damaged genes, and osteogenic differentiation potential. Furthermore, the expression of cardiac progenitor markers (PDGFR-α, VEGFR-2, and SSEA-1), cardiac transcription factors (GATA-4, NKx 2-5, ISL-1, TBX-5, TBX-18, and MeF-2C), and cardiovascular markers (cTNT, CD31, and α-SMA) were significantly reduced in ICHD AF-MSCs. Overall, these results suggest that the AF-MSCs of ICHD fetuses have proliferation defects with significantly decreased cardiomyogenic differentiation potential. Thus, these defects in ICHD AF-MSCs highlight that the impaired heart development in ICHD fetuses may be due to defects in the stem cells associated with heart development during embryogenesis.
La comprensión lectora de textos narrativos mediante el uso del storytelling digital en las re-des sociales: revisión sistemática
Authors: Suárez-Márquez Katherine Valeria 
Published: April 2023

Introducción: El artículo está estructurado en una revisión de la literatura, para conocer qué se ha hecho con el tema y qué aspectos aún quedan por estudiar. Objetivo: analizar investigaciones realizadas sobre la comprensión de textos narrativos a través del uso del storytelling digital en las redes sociales en estudiantes de básica secundaria mediante una revisión sistemática. Material y métodos: consistió en una sucesión de pasos para la revisión bibliográfica y científica de proyectos de investigación de maestría y especializaciones basada en la metodología de Manchado et al. (2009) sobre las revisiones sistemáticas exploratorias. Resultados: Los storytelling son un recurso didáctico que permite motivar, activar la atención y generar participación e interacción en los estudiantes. Conclusiones: el storytelling digital no se encuentra aún asociado a la comprensión lectora; por ende, es un deber pendiente en la investigación en el área de español y literatura.
The Importance of Women Participation in Ensuring Justice in Energy Transition in ASEAN and G7
Authors: Sumarno Theresia , Fitriyanti Vivi , Khusna Vivid , Yusgiantoro Inka 
Published: April 2023

Many countries have increased their climate ambitions, including net-zero by 2060. Gender equality is essential for just energy transition (JET). United Nations Sustainable Development Goals (SDG) 5 and 7 promote gender equality and access to sustainable energy for all. Women's participation in JET is crucial, yet they are underrepresented in the energy industry. This study promotes women's participation in the JET and strives to reconcile justice and inclusivity in the energy transition from upstream and downstream ASEAN beneficiaries with G7 precedents.
This paper aims to analyse the aspect of justice in the energy transition from women's perspectives in ASEAN and G7 countries. Most of the literature on women's issues in the energy sector is related to energy poverty and energy access. Hence, this paper will contribute to the literature on women's perspectives in the energy transition both in the workforce and in society as consumers.
This paper analyses to answer a question on “how far women in ASEAN have participated in the energy transition (leadership roles to end-users) compared to women in G7 economies?”. We use case studies with cross-analysis of ASEAN and G7 countries throughout this paper to demonstrate the contrast and similarity of gender equality in energy sector by exploring women’s experience as workers in the energy sector and as energy consumers (dirty to clean cooking – clean electricity).  We applied strategy basic research by conducting content analysis with intensive literature reviews, and additional aspects of women’s perspectives on this area, those who work and live in these regions to develop regional context. We also adopted the three tenets of justice by Jenkins et al (2016) and analysed the data collected using this framework.
This paper finds that ASEAN and G7 regions are almost at the same level in terms of women participation in ensuring a just energy transition. Despite having more women in the leadership roles in renewable energy sector, G7 is almost at the same level as ASEAN in their effort of improving women’s participation to accelerate and ensure a just transition in the regions.
Faktor â€“ Faktor yang Mempengaruhi Pemasaran Kopi Arabika (Study Kasus di Koperasi Klasik Beans Kabupaten Bandung Jawa Barat)
Authors: Hadriyana Teuku Ivan , Sendjaya Tuhpawana Priatna , Tachri Aik 
Published: April 2023

The purpose of this study is to identify the factors that influence the price of Arabica coffee in the Klasik Beans Cooperative, analyze the factors that influence the marketing of Arabica coffee in the Klasik Beans Cooperative, formulate the dominant factors that influence the relevant marketing used by the Klasik Beans Cooperative. Based on the results of regression analysis and further testing, the variables that affect the price of coffee are the amount of production, coffee quality and production risk. While the variables of land area and labor have no effect.Â Based on the results of regression analysis and further testing, the variables that affect income are the amount of production, coffee quality, land area and labor. While the production risk variable has no effect.
Respon Pertumbuhan Dan Hasil Tanaman Kangkung Darat (Ipomoea Reptans Poir) Sistem Akuaponik Akibat Pemberian Berbagai Jenis Pakan Ikan Lele
Authors: Nurmaydiana Latifah , Taryana Yana , Mulya Agus Surya 
Published: April 2023

Penelitian ini bertujuan untuk mengetahui pemberian berbagai jenis pakan ikan lele berpengaruh terhadap pertumbuhan tanaman kangkung dengan sistem akuaponik. Penelitian ini di laksanakan di lahan percobaan Desa Panyindangan pada bulan Juli sampai Agustus 2020. Rancangan Lingkungan pada penelitian ini menggunakan Rancangan Acak Kelompok(RAK) terdiri dari 5 perlakuan dan diulang sebanyak 5 kali perlakuan percobaan yaitu : A (Tanpa Pakan),B (Pakan Pelet),C (Pakan Magot),D (Pakan Azola+Pelet),E (Pakan Magot+Pelet). Jenis pakan ikan berpengaruh terhadap pengamatan jumlah daun 14 HST dengan perlakuan E (pakan maggot+pelet) dan D (Pakan Azola+Pelet) pada umur 30 HST,volume akar danÂ bobot basah tanaman. Jenis pakan yang paling baik yaitu perlakuan E (Pakan Magot+Pelet) pada pengamatan jumlah daun umur 30HST.
Assessing Grid Strength of 100% Inverter-Based Power Systems
Authors: Ma Fuyilong , Xin Huanhai , Wu Di , Liu Yun , Chen Xia 
Published: April 2023

<p>The increasing integration of renewable resources via power electronic inverters is shifting a modern power system toward a 100% inverter-based power system (IBPS). To maintain the stable operation of a 100% IBPS, it is important to identify the small-signal stability issues resulting from the interaction between the power network and inverter-based apparatuses. Due to the complexity of the interaction in a large-scale power system with many inverter-based apparatuses, grid strength assessment is a useful tool for fast identifying the stability issues. However, existing methods are not applicable to the 100% IBPS composed of gridfollowing (GFL) and grid-forming (GFM) inverters. To fill this gap, the paper proposes a method for fast assessing grid strength in terms of small-signal stability in the 100% IBPS. First, we formulate a multi-inverter system modeling for the small-signal stability analysis of the 100% IBPS. According to the analysis results, a measure and its threshold are then defined to characterize the gird strength of such a system. Also, an analytical expression is derived to determine the threshold and differentiate the impacts of GFL and GFM inverters on the stability boundary. Based on the defined measure and its threshold, our method is proposed and then validated on an IEEE 39-bus system dominated by GFL and GFM inverters.</p>