bluuebunny/crossref_metadata_2025_split huggingface dataset:
AMEERA-3: Randomized Phase II Study of Amcenestrant (Oral Selective Estrogen Receptor Degrader) Versus Standard Endocrine Monotherapy in Estrogen Receptor–Positive, Human Epidermal Growth Factor Receptor 2–Negative Advanced Breast Cancer
Authors: Tolaney Sara M. , Chan Arlene , Petrakova Katarina , Delaloge Suzette , Campone Mario , Iwata Hiroji , Peddi Parvin F. , Kaufman Peter A. , De Kermadec Elisabeth , Liu Qianying , Cohen Patrick , Paux Gautier , Wang Lei , Ternès Nils , Boitier Eric , Im Seock-Ah 
Published: June 2023

PURPOSE Amcenestrant (oral selective estrogen receptor degrader) demonstrated promising safety and efficacy in earlier clinical studies for endocrine-resistant, estrogen receptor–positive/human epidermal growth factor receptor 2–negative (ER+/HER2–) advanced breast cancer (aBC). PATIENTS AND METHODS In AMEERA-3 (ClinicalTrials.gov identifier: NCT04059484 ), an open-label, worldwide phase II trial, patients with ER+/HER2– aBC who progressed in the (neo)adjuvant or advanced settings after not more than two previous lines of endocrine therapy (ET) were randomly assigned 1:1 to amcenestrant or single-agent endocrine treatment of physician's choice (TPC), stratified by the presence/absence of visceral metastases, previous/no treatment with cyclin-dependent kinase 4/6 inhibitor, and Eastern Cooperative Oncology Group performance status (0/1). The primary end point was progression-free survival (PFS) by independent central review, compared using a stratified log-rank test (one-sided type I error rate of 2.5%). RESULTS Between October 22, 2019, and February 15, 2021, 290 patients were randomly assigned to amcenestrant (n = 143) or TPC (n = 147). PFS was numerically similar between amcenestrant and TPC (median PFS [mPFS], 3.6 v 3.7 months; stratified hazard ratio [HR], 1.051 [95% CI, 0.789 to 1.4]; one-sided P = .643). Among patients with baseline mutated ESR1; (n = 120 of 280), amcenestrant numerically prolonged PFS versus TPC (mPFS, 3.7 v 2.0 months; stratified HR, 0.9 [95% CI, 0.565 to 1.435]). Overall survival data were immature but numerically similar between groups (HR, 0.913; 95% CI, 0.595 to 1.403). In amcenestrant versus TPC groups, treatment-emergent adverse events (any grade) occurred in 82.5% versus 76.2% of patients and grade ≥3 events occurred in 21.7% versus 15.6%. CONCLUSION AMEERA-3 did not meet its primary objective of improved PFS with amcenestrant versus TPC although a numerical improvement in PFS was observed in patients with baseline ESR1 mutation. Efficacy and safety with amcenestrant were consistent with the standard of care for second-/third-line ET for ER+/HER2– aBC.
Empirical analysis and modeling of the allometric scaling of urban freight systems
Authors: Lin Xu-Jie , Liu Er-Jian , Yang Yitao , Jia Xiang-Yu , Yan Xiao-Yong 
Published: June 2023

Abstract
Heavy trucks which undertake the majority of freight volume play an important role in urban freight systems. By analyzing heavy truck trip data, we find a superlinear scaling relationship for heavy truck trips and a sublinear scaling relationship for heavy truck numbers relative to urban population size. Although these allometric scaling relationships that widely appear in nature and social systems have been explained by many models, a simple model that can cover a wide range of scaling exponents in these systems is still lacking. Here, we develop a partially mixing city operation model by quantifying the mixability of the urban population to explain why the superlinear and sublinear scaling exponents are in the range of 1 and

. This simple model not only helps us understand the mechanism of allometric scaling of urban freight systems, but also provides a new framework for other superlinear and sublinear scaling relationships in cities.
Remembering Aronowitz
Authors: Pelias Michael 
Published: June 2023

Abstract
Stanley Aronowitz was the archetypical organic intellectual, one who maintained critical theory in its most substantive and adaptive form. Never one to succumb to defeatism or intellectual retreat, he maintained the grand narrative of emancipatory politics and education. His immense range of inquiry is best articulated in four distinct yet overlapping periods that exemplify the theoretical foresight and relevance for future radical speculation and praxis.
When Stanley Aronowitz Went to Business School
Authors: Carter Chris , Harney Stefano 
Published: June 2023

Abstract
The authors reflect on Stanley Aronowitz's influence in the 2000s on the then emerging fields of critical accounting and critical management studies, recalling his visits to Leicester University, and the subsequent visit the authors organized together where Stanley was hosted for extended periods at Queen Mary University of London and St. Andrews University. Stanley's influence is still felt in UK institutions practicing a critical approach.
Effectors of anterior morphogenesis in C. elegans embryos
Authors: Balasubramaniam Boopathi , Topalidou Irini , Kelley Melissa , Meadows Sarina M. , Funk Owen , Ailion Michael , Fay David S. 
Published: June 2023

ABSTRACT
During embryogenesis the nascent Caenorhabditis elegans epidermis secretes an apical extracellular matrix (aECM) that serves as an external stabilizer, preventing deformation of the epidermis by mechanical forces exerted during morphogenesis. At present, the factors that contribute to aECM function are mostly unknown, including the aECM components themselves, their posttranslational regulators, and the pathways required for their secretion. Here we showed that two proteins previously linked to aECM function, SYM-3/FAM102A and SYM-4/WDR44, colocalize to intracellular and membrane-associated puncta and likely function in a complex. Proteomics experiments also suggested potential roles for SYM-3/FAM102A and SYM-4/WDR44 family proteins in intracellular trafficking. Nonetheless, we found no evidence to support a critical function for SYM-3 or SYM-4 in the apical deposition of two aECM components, NOAH-1 and FBN-1. Moreover, loss of a key splicing regulator of fbn-1, MEC-8/RBPMS2, had surprisingly little effect on the abundance or deposition of FBN-1. Using a focused screening approach, we identified 32 additional proteins that likely contribute to the structure and function of the embryonic aECM. We also characterized morphogenesis defects in embryos lacking mir-51 microRNA family members, which display a similar phenotype to mec-8; sym double mutants. Collectively, these findings add to our knowledge of factors controlling embryonic morphogenesis.
Is depressed mood clinically relevant at the onset of schizophrenia? A longitudinal study.
Authors: Pelizza Lorenzo , Leuci Emanuela , Quattrone Emanuela , Paulillo Giuseppina , Azzali Silvia , Pupo Simona , Pellegrini Pietro 
Published: June 2023

Aim of the studyThe aims of this investigation were: (1) to calculate baseline prevalence of FES patients with relevant depressed mood (DM), (2) to longitudinally monitor DM levels over a 12-month follow-up, and (3) to investigate their associations with clinical data and the specific treatment components of an “Early Intervention in Psychosis” (EIP) program.Subject or material and methodsThe Positive And Negative Syndrome Scale (PANSS) was completed by all FES participant. Individuals with a baseline PANSS “Depression” item subscore of ≥ 5 were classified as having relevant depressed mood (FES/DM+). Chi-square and Mann-Whitney tests were used for inter-group comparisons. A linear regression analysis was also performed.ResultsFifty-three (33.3%) participants were in the FES/DM+ subgroup. Relevant baseline DM at baseline was associated with female gender and a higher PANSS “Positive Symptoms” score. Across the follow-up, FES individuals improved their DM levels. This was significantly related to a longitudinal decrease in PANSS “Positive Symptoms” levels.DiscussionMore than 1/3 of FES subjects had relevant DM already at the recruitment time in an EIP service. This suggests that relevant depression in FES subjects is usually under-treated. Moreover, we observed a significant decrease in DM severity levels across the follow-up. This decrease was associated with the longitudinal severity reduction in positive symptom levels, reflecting their state-related fluctuations.ConclusionsDM is relatively frequent in FES, already at the recruitment in EIP services. However, its severity decreases overtime within specialized EIP programs.
Nursing students' skills in applying short-stretch compression bandages using the control of compression bandaging score
Authors: Bobbink Paul , Gschwind Géraldine , Probst Sebastian 
Published: June 2023

Aim: To assess the feasibility using the Control of Compression Bandaging (CCB) score to measure skills development on short-stretch compression therapy during a second-year nursing students' workshop. Design: A quasi-experimental pilot study with one group. Method: All students followed a blended learning unit comprising an e-learning unit on leg ulcers and compression therapy including videos, followed by hands-on workshops where they could exercise how to apply short-stretch compression bandages. Clinical nurse specialists in wound care collected pre- and post-workshop measures. Data collection included feasibility, absolute pressure under compression bandages and the CCB score. Results: Six clinical nurse specialists (CNSs) collected data and 16 students participated in this pilot study. The mean application time was 8.02 minutes (min=2, max=20) pre and 9.25 minutes (min=5, max=17) post workshop. Pressure under compression bandages increased at the forefoot (P=0.01) and the calf muscle base (P=0.03) post workshop. One extreme outlier was observed. In addition, the CCB score increased from 3.57 to 4.47 (P=0.16). Using pressure measuring devices was described as essential by all the CNSs and the CCB score was easy to use. Conclusion: Using the CCB score and pressure measuring devices were feasible during an undergraduate education session. Recruitment procedure and modality of data collection were satisfactory. This score may be a valuable way to assess students' skills in short-stretch compression therapy. If used for formal assessment, a passing score should be defined.
Getting wound care right: evaluation of a week of intensive teaching on wound care for undergraduate nursing students
Authors: Stephens Melanie , Wynn Matthew , Pradeep Sheba , Staniecka Karolina , Gill Anna , Brown Erin , Matthew Charlotte 
Published: June 2023

Introduction: Tissue viability skills are essential for nurses, but education on this in undergraduate programmes can be inadequate. After approval of the Future Nurse curriculum in 2019, a small team of staff at the University of Salford developed a Getting Wound Care Right week to improve students' knowledge and clinical skills. Methods: To evaluate the week, the 250 students who had participated in all activities were invited 6 months after the week to contribute a 250-word reflection for a case series. The aim of this was to understand the impact of the week on participants' knowledge, skills and confidence in caring for patients with wounds and whether it had sparked interest in further learning. Results: Four students contributed reflections, which were overwhelmingly positive. They described the knowledge attained, which included that on anatomy and physiology of the skin and wound healing, evidence-based assessment, treatment and management of wounds, and the impact of wounds on patients' quality of life. Skills gained included those in categorisation of wounds, wound assessment and pressure redistribution when seated. Responses on the impact on clinical practice focused on the importance of multidisciplinary working within wound care, seating provision for pressure ulcer prevention and management, and dressing selection. Negative comments related to students realising that clinical practice could be improved rather than indications that the format is ineffective or inappropriate. Limitations of the evaluation included the small number of participants and a lack of responses from every field of practice. Conclusions: The Getting Wound Care Right week format is a viable approach to meeting Future Nurse curriculum requirements. The approach could be enhanced by a greater emphasis on the relevance of wound care teaching to children and young people's nursing students. The week improved students' clinical confidence on placements when caring for patients with wounds. Further robust evaluation of the module is needed to confirm the findings of this initial evaluation.
Hydrodynamic Analysis of Shallow Water Sloshing in Ship Chamber Under Longitudinal Earthquake
Authors: Yang Jianbao , Zhang Yang , Shi Duanwei 
Published: June 2023

Shallow water sloshing-structure interaction under the coupled longitudinal and pitch motions resulted by the longitudinal earthquake directly affects the structural safety of the shiplift. However, no matter in shiplift or other related fields, there is little research on this aspect at present. As a basis of structural dynamics analysis and earthquake resistant design, an analytical method including a developed modal system and new engineering formulas is presented to predict the hydrodynamic moment and force in the ship chamber. Based on the linear modal theory, a modal system describing shallow water sloshing under longitudinal earthquake is developed with infinite set of modal functions. Then, new engineering formulas for calculating the hydrodynamic moment and force are proposed with only retaining the lowest sloshing mode (n=1). Case simulations suggest that the maximum error of hydrodynamic moment and force between n=1 and n=100 are lower than 1.3% and 10.5%, respectively. In addition, the hydrodynamic moment resulting from pressure on the walls can be reasonably ignored, which accounts for less than 0.5% percent of total hydrodynamic moment. With respect to the currently used Housner model, the presented formulas are greatly improved in computational accuracy and rationally supplement the missing part in the seismic design part of the Design code for shiplift.
Issues arising from the study design, conduct, and promotion of clinical trials funded by opioid manufacturers: a review of internal pharmaceutical industry documents
Authors: Gac Brian W. , Yakubi Hanna , Apollonio Dorie E. 
Published: June 2023

Background:From 1999 to 2021 opioid overdoses caused over one million deaths in the US. The pharmaceutical industry has been held legally responsible in some cases for overstating the benefits and understating the risks of opioid use, leading to overprescribing that contributed to these deaths.
Aims and objectives:In this study we describe issues with research funded by opioid manufacturers that was used to support increased opioid prescribing.
Methods:We analysed 503 internal industry documents from opioid manufacturers released from State of Oklahoma v. Purdue Pharma, LP, et al in January 2020.
Findings:Internal documents identified three research practices of concern – enriched enrollment, ghostwriting, and overstatement of research findings – that resulted in claims that opioids were safe, nonaddictive, and effective in treating pain. These claims were used to promote increased opioid use.
Discussion and conclusions:Research created by opioid manufacturers distorted the addictive potential of opioids using strategies that hid authorship and overstated findings. The claims were used in marketing and promotional materials to promote opioids as being safe and effective.
High-precision digital optical phase locking for 10−12  W order weak light for a spaceborne gravitational wave interferometer
Authors: Mu Henglin , Le Taoran , Xu Xin , Tan Yidong , Wei Haoyun , Li Yan 
Published: June 2023

We developed a digital optical phase-locking loop (DOPLL) for weak light phase locking in spaceborne gravitational wave interferometers (SGWIs). Using the system, we successfully locked the phase of the slave laser to the master laser with the power of only several picowatts, much smaller than the LISA requirement (100 pW). The system does not introduce steady-state errors, and the Bode diagram shows its stability. The out-loop phase noise floor (2.3×10−4 and 5.2×10−4rad/Hz1/2) is very close to the shot noise limit. The Allan standard deviation of the heterodyne signal reaches 3.1×10−17 at 1000 s. With the previous automatic locking program designed by other researchers, the results demonstrate that DOPLLs have bright application prospects and can be applied in the transducer of the SGWI.
Design of optical anapole modes of all-dielectric nanoantennas for SERS applications
Authors: Wang Debao , Lv Jingwei , Wang Jianxin , Ren Yanru , Yu Ying , Li Wei , Chu Paul K. , Liu Chao 
Published: June 2023

To obtain large electric field enhancement while mitigating material losses, an all-dielectric nanoantenna composed of a heptamer and nanocubes is designed and analyzed. A numerical simulation by the finite element method reveals that the nanoantenna achieves the optical electric anapole modes, thereby significantly enhancing the coupling between different dielectrics to further improve the near-field enhancement and spontaneous radiation. Field enhancement factors |E/E0|2 of 3,563 and 5,395 (AM1 and AM2) and a Purcell factor of 3,872 are observed in the wavelength range between 350 and 800 nm. This nanoantenna has promising potential in applications involving surface-enhanced Raman scattering and nonlinearities due to its low cost and excellent compatibility.
FREQUENCY OF OCCURRENCE OF PHONEMES IN HINDI
Authors: N Sreedevi , M Irfana , Paulson Anu Rose 
Published: June 2023

Hindi, an Indo-Aryan language is the national language of India and the state language of various North Indian states of India such as Madhya Pradesh, Delhi, Uttar Pradesh etc. Statistics on the phonemes of a language provides useful information in the field of speech language pathology, audiology, linguistics and communication engineering. The data can be effectively used for the assessment and selection of target phonemes for treatment of various communication disorders, develop phonetically balanced word lists for audiological testing, and teach foreign language. It also provides valuable information to device text to speech systems and automatic speech recognition systems. The earlier data on frequently occurring phonemes in numerous Indian languages were derived from written sources. However, information from spoken language may be of more significance compared to written language. The aim of the present study was to determine the frequently occurring phonemes in spoken Hindi. Participants were native speakers of Hindi in the age range of 20 to 70 years. Eighteen group conversation samples were recorded. The samples were transcribed using IPA transcription. Systematic Analysis of Language Transcripts (SALT) software was used to analyze the samples in order to obtain the frequently occurring phonemes. Descriptive statistics was applied for the same. Results revealed that phonemes /n, a, e, f, h, k/ were the most frequently occurring phonemesin Hindi. Aspirated phonemes (/gh/, /ʈh/, /ph/, /ɖh/) were the least present phonemes in the data. High and front vowels were more frequently present in spoken Hindi. Considering the manner of articulation, nasals and stops had higher occurrence. Alveolar dominated considering the place of articulation of phonemes. The applications of the study are extensive and can be utilized efficiently in a variety of disciplines.
Deep learning models for multilabel ECG abnormalities classification: A comparative study using TPE optimization
Authors: Rawi Atiaf A. , Elbashir Murtada K. , Ahmed Awadallah M. 
Published: June 2023

AbstractThe problem addressed in this study is the limitations of previous works that considered electrocardiogram (ECG) classification as a multiclass problem, despite many abnormalities being diagnosed simultaneously in real life, making it a multilabel classification problem. The aim of the study is to test the effectiveness of deep learning (DL)-based methods (Inception, MobileNet, LeNet, AlexNet, VGG16, and ResNet50) using three large 12-lead ECG datasets to overcome this limitation. The define-by-run technique is used to build the most efficient DL model using the tree-structured Parzen estimator (TPE) algorithm. Results show that the proposed methods achieve high accuracy and precision in classifying ECG abnormalities for large datasets, with the best results being 97.89% accuracy and 90.83% precision for the Ningbo dataset, classifying 42 classes for the Inception model; 96.53% accuracy and 85.67% precision for the PTB-XL dataset, classifying 24 classes for the Alex net model; and 95.02% accuracy and 70.71% precision for the Georgia dataset, classifying 23 classes for the Alex net model. The best results achieved for the optimum model that was proposed by the define-by-run technique were 97.33% accuracy and 97.71% precision for the Ningbo dataset, classifying 42 classes; 96.60% accuracy and 83.66% precision for the PTB-XL dataset, classifying 24 classes; and 94.32% accuracy and 66.97% precision for the Georgia dataset, classifying 23 classes. The proposed DL-based methods using the TPE algorithm provide accurate results for multilabel classification of ECG abnormalities, improving the diagnostic accuracy of heart conditions.
New Evidence on Nicanor’s Theory of Punctuation
Authors: Nünlist René 
Published: June 2023

Abstract
A concise summary of Nicanor’s theory of punctuation that has recently been discovered in a codex mixtus of the 15th century throws precious new light on a topic of some complexity. The general picture that emerges from the new extract does not substantially differ from that of the other known summary, which has been the starting point for all modern reconstructions of Nicanor’s theory. Therefore, these reconstructions need not be rewritten on a larger scale. The two summaries nevertheless display some telling differences in how they explain and present the details, not least when read against the backdrop of Nicanor’s actual practice that can be derived from the relevant scholia to Homer. The purpose of the present article is to assess the new discovery especially with regard to these differences and their effects on how Nicanor’s theory is to be reconstructed.
Exitium Troiae funestaque flamma. Il personaggio di Paride nell’Ilias Latina
Authors: Aricò Giuseppe 
Published: June 2023

Abstract
The character of Paris in the Ilias Latina maintains the ambiguity that characterises him in the Greek Iliad, where he does not lack military attitudes, but chafes against his duties to his country, being committed instead to satisfying his taste for luxury. This ambiguity is even reinforced in the epitome. The ‘heroic’ aspect of Paris’ personality emerges in a clearer light, expressed in a more mature awareness of his obligations to his family and country, but the other aspect, his indolence, is also accentuated: the character becomes a true elegiac lover, immersed in the experience of an exalted passion that partly distinguishes him from the cliché of the libertine of the Homeric tradition. It might therefore seem legitimate to interpret the Paris of the Ilias Latina in a more positive key than the Homeric character. However, this exegesis is opposed by the judgement expressed by the authorial voice at many significant points of the story: by his dissolute and unscrupulous behaviour, Paris has started a war that will lead to the ruin of his country; he himself is thus his own funesta ruina (234), the funesta ... flamma (253) that will burn down Troy and his own fate.
“L’importante è finire”. Ancora a proposito del riuso di Verg.Aen.4.415 in Auson.Epigr.75.8 Green
Authors: Ortoleva Vincenzo 
Published: June 2023

AbstractIn the complete quotation of Verg.Aen.4.415 in Auson.Epigr.75.8 Green, the participlemoritura, originally referring to Dido, takes on the obscene double entendre of “about to orgasm”, matching analogous attestations of this distinctive sense of the verbmorior.