bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analisis Ilmu Arudh pada Syair "Qod Kafani" Karya Abdullah bin Alawi al-haddad
Authors: Abdul  
Published: September 2023

Syair adalah ucapan atau tulisan dengan wazan atau bahr ber qafiyah dan elemen ekspresi rasa. Peneliti menggunakan metode deskriptif kualitatif dan melakukan studi kepustakaan. Tujuan dari penelitian ini adalah untuk mendeskripsikan jenis bahr dan zihaf yang ditemukan dalam Syair Qod Kafani, yang ditulis oleh Imam Abdullah bin Alawi bin Muhammad al-Haddad saat dia memiliki hajat kepada Allah SWT. Pendekatan yang digunakan untuk mengkaji beberapa pola yang ditemukan dalam syair ini adalah Ilmu Arudh. Dalam penelitian ini, studi pustaka digunakan sebagai metode pengumpulan data untuk mendapatkan informasi dari buku, artikel, makalah, atau sumber terpercaya lainnya yang relevan dengan topik penelitian. Peneliti menggunakan Divan al-ʼImam al-Haddad al-Durr al-Manzûm Lidzawi al-Uqûl wa al-Fuhûm, yang berisi kumpulan Syair sebagai sumber data pokok. Hasil penelitian menunjukkan bahwa Bahr Raml adalah jenis bahr yang digunakan dalam syair Qod Kafani oleh Imam Abdullah bin Alawi bin Muhammad al-Haddad. Disisi lain, terdapat dua jenis zihaf yang masuk ke dalam syair "Qod Kafani": Zehaf Khan dan Zehaf Kaff Thawil.
Kata kunci: Syair Qod Kafani, Ilmu Arudh, Bahr, Zihaf
تطبيق أسلوب التدريبات (Drill) لتحسين مهارة الكلام لدى طلاب الصف الثامن ه بمدرسة منبع الصالحين المتوسطة سوجي منيار غرسيك
Authors: Ridwan Muhammad Farih 
Published: September 2023

ABSTRAK
Terdapat kebutuhan akan Bahasa Arab, akan tetapi kualitas peserta didik rendah, dan ini terjadi pada siswa kelas 8 MTs Mamba’us Sholihin. Oleh karena itu peningkatan harus dilakukan dalam pembelajaran bahasa Arab dengan menggunakan teknik Drill agar proses pembelajaran berjalan dengan baik dan memberikan hasil yang lebih baik. Berdasarkan latar belakang tersebut, dalam proses pembelajaran harus ada teknik yang digunakan agar siswa dapat memahami segala sesuatu yang diajarkan dan mencapai tujuan pembelajaran. Penelitian ini merupakan penelitian kualitatif dengan jenis penelitian tindakan kelas. Penelitian tindakan kelas merupakan kegiatan mengamati objek dengan menggunakan kaidah metodologi tertentu untuk memperoleh data dan informasi yang berguna. Teknik analisis data menggunakan reduksi, penyajian data dan penarikan kesimpulan.
Hasil dari penelitian ini adalah bahwa prosentase rata-rata peningkatan kemampuan berbicara siswa terus meningkat pada setiap pertemuan. Namun pada siklus I prosentase skor rata-rata tidak mencapai target yang ditetapkan yaitu sebesar 25%. Kemudian pada siklus II prosentase hasil rata-rata mencapai 62,5%. Dalam hal ini dapat dikatakan tidak ada lagi kendala dalam proses pembelajaran dan penggunaan media pembelajaran pada penerapan teknik drill terbukti dapat meningkatkan keterampilan berbicara siswa kelas 8 MTs Mamba’us Sholihin. Kemudian rata-rata kenaikan antara prosentase dari siklus pertama ke siklus kedua adalah 81,25%.
Kata kunci: Metode drill, keterampilan berbicara.
Platelet Activating Factor Acetylhydrolase (PAF-AH) activity : could it have a role on coagulation in covid-19 patients?
Authors: BAYRAK Tülin , ŞENER Gülsen , SAĞLAM GÖKMEN Emel , BAYRAK Ahmet 
Published: September 2023

Objective: Abnormal immune inflammatory response and cytokine storm play an important role on the aspect of increasing mortality in Covid-19. We aimed to investigate whether the Platelet Activating Factor Acetylhydrolase activity (PAF-AH) and hematological parameters have prognostic and predictive value in determining the disease severity.
Methods: A total of 84 Covid-19 patients, 52 of whom were hospitalized in the ward and 32 in the intensive care unit (ICU), and 38 control patients were included in this study.
Results: Lymphocyte and serum albumin levels were significantly lower (p < .001) and age, neutrophils, CRP, procalcitonin, LDH, INR, D-dimer levels were significantly higher (p < .001) in Covid-19 patients compared to the control group. ICU patients had significantly lower (p < .001) lymphocyte, albumin values and significantly higher (p < .001) age, leukocyte, neutrophils, CRP, INR, aPTT, D-dimer levels compared to ward patients. PAF-AH activity was significantly increased in ICU patients compared to the control group (p < .05). A positive correlation was found between PAF-AH and D-Dimer in the ICU group.
Conclusion: We found increased PAF-AH activity in patients with Covid-19. It’s important to spot the PAF-AH activity in cardiovascular events that develop due to coagulation problems, which are likely to be seen on these patients in the future.
Reliability, Concurrent Validity, and Minimal Detectable Change of a Smartphone Application for Measuring Thoracic Kyphosis
Authors: ŞAHİNOĞLU Ertan , ERGİN Gülbin , BAKIRHAN Serkan , ÜNVER Bayram 
Published: September 2023

Objective: To assess the intra- and inter-rater reliability and concurrent validity, and to estimate minimal detectable change of a smartphone application for measuring thoracic kyphosis angle.
Methods: A total of 80 healthy university students were evaluated. Two raters measured the thoracic kyphosis angle using a digital inclinometer and the smartphone application. Intra- and inter-rater reliability were assessed using the intraclass correlation coefficient (ICC) with 95% confidence interval. The standard error of measurement (SEM) and the minimal detectable change at the 95% confidence level (MDC95) were also calculated. The concurrent validity between the digital inclinometer and the smartphone application was assessed by the linear regression analysis and Bland and Altman's 95% limits of agreement method.
Results: The intra- and inter-rater reliability were excellent for the digital inclinometer and the smartphone application (ICC > 0.75). The SEM values for the digital inclinometer and the smartphone application were close together. The MDC95 values for the smartphone application were 5.11 and 6.30 degrees, and 9.02 degrees for intra- and inter-rater, respectively. The digital inclinometer and the smartphone application showed a positive correlation (R2 = 0.85). The Bland-Altman plot showed a good agreement between the instruments.
Conclusion: The smartphone application used in this study is a cost-effective, practical, reliable, and valid instrument for measuring the thoracic kyphosis angle. More than 9 degrees in the value of the thoracic kyphosis angle measured by the smartphone application can be considered as a true change.
Nasal Sprays Containing Mometasone Furoate Can Be Used Prophylactically in COVID-19 Infection and Related Smell Disorders
Authors: ENÖZ Murat , ÖZDEMİR Mücahit , YALCİN Bahattin 
Published: September 2023

Objective: We aimed to emphasize the possible beneficial effects of intranasal sprays containing mometasone furoate, especially for preventive treatment or supportive treatment in patients with olfactory disorders due to damage to the olfactory area, or for regular use in healthcare workers with a high risk of close contact.
Methods: Preventive and therapeutic scientific studies are continuing around the world for viral spread and viral damage associated with the Coronavirus disease 2019 (COVID-19) pandemic. We investigated the attachment of the COVID-19 virus in the nose and entry into the body with the crystal structure of the spike and Angiotensin-Converting Enzyme 2 (ACE-2) proteins, a molecular docking study. This scientific study is the first in-silico study to investigate the possible antiviral effects of Mometasone furoate molecules on spike protein and to show the antiviral effect of mometasone furoate on COVID-19.
Results: We think that nasal sprays containing mometasone furoate can be used prophylactically in patients with COVID-19 infection due to its antiviral effect, and it may be beneficial to use sprays containing mometasone furoate before the symptoms of upper respiratory tract infection begin in patients.
Conclusions: The role of these molecules in the treatment of acute smell disorders associated with COVID-19 infection and their antiviral effects on coronavirus should be investigated by conducting extensive scientific studies on the subject.
Effect of Reboxetine Treatment on BDNF, Synaptophysin, and PSD-95 Levels in the Spinal Dorsal Horn of Rats with Diabetic Neuropathy
Authors: TURAN YÜCEL Nazlı , ÜÇEL Umut İrfan , DEMİR ÖZKAY Ümide , ULUPINAR Emel , CAN Özgür Devrim 
Published: September 2023

Objective: It is known that neuropathic pain is accompanied by alterations in the levels of neurotrophic factors and synaptic proteins in the microenvironment of the spinal dorsal horn. Such changes contribute to hyperalgesia and allodynia processes; thus, analgesic drugs can exert their pharmacological effects by affecting the expressions, levels, or functions of these endogenous substances. In this study, based on the knowledge that reboxetine (a selective noradrenaline reuptake inhibitor) has the potential for antihyperalgesic efficacy in diabetic neuropathy, we aimed to examine the probable effects of this drug on diabetes-induced changes in brain-derived neurotrophic factor (BDNF), synaptophysin (the pre-synaptic marker of synaptic integration), and postsynaptic density-95 (PSD-95) (the postsynaptic marker of synaptic integration) levels in the superficial laminae of the dorsal horn.
Methods: Experimental diabetes was induced by a single-dose injection of streptozotocin (STZ) (50 mg/kg) in rats. After four week-long induction period of painful diabetic neuropathy, rats were treated orally with 8 mg/kg reboxetine for two weeks. Hyperalgesia responses were evaluated by using the Randall–Selitto and Hargreave's tests. Following the pain tests, immunohistochemical studies were performed.
Results: Two weeks of reboxetine administration increased the reduced paw withdrawal thresholds and shortened the paw withdrawal latencies of diabetic rats in neuropathic pain tests, indicating the antihyperalgesic efficacy of this drug. Moreover, augmented BDNF and synaptophysin levels in diabetic rats reversed by reboxetine treatment. However, there was no alteration in the densities of PSD-95, in both STZ-diabetic and reboxetine-treated STZ-diabetic rats.
Conclusion: The obtained results suggested that inhibition of central sensitization and modulation of spinal plasticity seem to be pharmacological mechanisms underlying reboxetine's antihyperalgesic effects on diabetic rats. However, further studies are still needed to clarify the exact mechanism of action.
Initiation and Training of Adolescent Health Cadres of Poskestren in Mantikulore District City of Palu
Authors: Kusumawati Dwi Erma , Ansar Ansar , Adhyanti Adhyanti 
Published: September 2023

Health promotion in adolescents is one of the alternative solutions to improve the health status of the community. Efforts that can be made in Islamic boarding schools are through the revitalization of Poskestren and adolescent health cadres . This activity aims to initiate and train youth health cadres in Islamic boarding schools. The activity was carried out in September 2021 at the Hidayatullah Tondo Islamic Boarding School and the Liwa'ul Haq Islamic Boarding School in Palu City. The method of activity is through surveys, brain storming and discussion, simulations and demonstrations. The results show that pesantren health posts (Poskestren) have been successfully established in 2 activity locations. There is an increase in the knowledge of Poskestren cadres from before being given training compared to after being given training. It is recommended that this activity can be continued and the need for further training activities with other contents such as basic health, environmental health, reproductive health and others.
Development and validation of a non-invasive model for predicting significant fibrosis based on patients with nonalcoholic fatty liver disease in the United States
Authors: Guo Yuanhui , Shen Baixuan , Xue Yanli , Li Ying 
Published: September 2023

BackgroundLiver fibrosis is closely related to abnormal liver function and liver cancer. Accurate noninvasive assessment of liver fibrosis is of great significance for preventing disease progression and treatment decisions. The purpose of this study was to develop and validate a non-invasive predictive model for the asses`sment of significant fibrosis in patients with non-alcoholic fatty liver disease.MethodsInformation on all participants for 2017-2018 was extracted from the NHANES database. The eligible patients with significant fibrosis (n=123) and non-significant fibrosis (n=898) were selected to form the original dataset. Variable selection was performed using least absolute shrinkage and selection operator (Lasso) regression, and multivariate logistic regression analysis was used to develop a prediction model. The utility of the model is assessed in terms of its discrimination, calibration and clinical usability. Bootstrap-resampling internal validation was used to measure the accuracy of the prediction model.ResultsThis study established a new model consisting of 9 common clinical indicators and developed an online calculator to show the model. Compared with the previously proposed liver fibrosis scoring system, this model showed the best discrimination and predictive performance in the training cohort (0.812,95%CI 0.769-0.855) and the validation cohort (0.805,95%CI 0.762-0.847), with the highest area under curve. Specificity(0.823), sensitivity(0.699), positive likelihood ratio(3.949) and negative likelihood ratio(0.366) were equally excellent. The calibration plot of the predicted probability and the actual occurrence probability of significant fibrosis shows excellent consistency, indicating that the model calibration is outstanding. Combined with decision curve analysis, this model has a great benefit in the range of 0.1-0.8 threshold probability, and has a good application value for the diagnosis of clinical significant fibrosis.ConclusionThis study proposes a new non-invasive diagnostic model that combines clinical indicators to provide an accurate and convenient individualized diagnosis of significant fibrosis in patients with non-alcoholic fatty liver disease.
Association between serum vitamin D levels and sensitivity to thyroid hormone indices: a cross-sectional observational study in NHANES 2007–2012
Authors: Chen Si , Yang Wei , Guo Zhen , Lv Xiaofei , Zou Yandun 
Published: September 2023

ObjectiveWe designed this study to determine whether there is a link between vitamin D levels and sensitivity to thyroid hormone and to provide a new perspective for studying the relationship between vitamin D and thyroid disease.MethodsOur study included 8,126 participators from the National Health and Nutrition Examination Survey (NHANES) database between 2007 and 2012. We used weighted multiple linear regression models to enquire the connection between serum vitamin D levels and thyroid hormone sensitivity indicators, including the following: Thyroid-stimulating hormone index (TSHI), Free Triiodothyronine/Free thyroxine (FT3/FT4), Thyroid Feedback Quantile-based Index (TFQI), and Thyrotroph Thyroxine Resistance Index (TT4RI). Finally, we used constrained cubic splines to explore possible nonlinear relationships. All data cleaning and statistical analyses were performed using R software.ResultsThe final Results were reached after adjusting for various confounding factors. We found a U-shaped relationship between TFQI and serum vitamin D, and the lowest TFQI appeared when the serum vitamin D concentration was 25.77ng/ml. However, an inverse U-shaped relationship was found between FT3/FT4 and vitamin D levels. When the serum vitamin D concentration was 25.43ng/ml, the ratio of FT3/FT4 was the highest.ConclusionIn the US population, our study concluded that FTQI and FT3/FT4 were U-shaped or inverse-U-shaped with serum vitamin D levels respectively after several adjustments. Therefore, FTQI and FT3/FT4 are considered indicators of the complex relationship between thyroid hormone resistance and vitamin D metabolism. In the future, more complex prospective investigations are needed to confirm these findings and find a causal link between them.
Assessment of above ground biomass and soil organic carbon in the forests of Nepal under climate change scenario
Authors: Malla Rajesh , Neupane Prem Raj , Köhl Michael 
Published: September 2023

IntroductionMany factors, such as climate, topography, forest management, or tree/forest attributes, influence soil organic carbon (SOC) and above-ground tree biomass (AGTB). This study focuses on assessing relationship between various predictor variables and response variables (SOC and AGTB) in the perspective of climate change scenario. The study was conducted throughout in Nepal using forest resource assessment data (2010–2014).MethodsOur study applied a random forest model to assess the status of SOC and AGTB under future climate change scenarios using 19 bioclimatic variables accompanied by other variables such as altitude, aspect, basal area, crown cover development status, distance to settlement forest types, number of trees, macro-topography, management regime, physiographic zones, slope, and soil depth. The study used 737 (70%) samples as a training data for model development while 312 (30%) samples as a testing data for model validation.Results and discussionThe respective RMSE, RMSE% and adjusted R2 of the Random Forest Model for SOC estimation were found to be 9.53 ton/ha, 15% and 0.746 while same for the AGTB were 37.55 ton/ha, 21.74% and 0.743. Particularly, changes in temperature and precipitation showed an effect on the amount of SOC and AGTB in the projected scenario i.e., CMIP6, SSP2 4.5 for 2040–2060. The study found the amount of SOC decreased by 3.85%, while AGTB increased by 2.96% in the projected scenario. The proposed approach which incorporates the effect of bioclimatic variables can be a better option for understanding the dynamics of SOC and AGTB in the future using climatic variables.
A novel marker integrating multiple genetic alterations better predicts platinum sensitivity in ovarian cancer than HRD score
Authors: Yang Fan , Wei Wei , Li Ganghua , Lan Qiongyu , Liu Xiwei , Gao Lin , Zhang Chao , Fan Jiangtao , Li Jundong 
Published: September 2023

Introduction: Platinum-based chemotherapy is the first-line treatment strategy for ovarian cancer patients. The dismal prognosis of ovarian cancer was shown to be stringently associated with the heterogeneity of tumor cells in response to this therapy, therefore understanding platinum sensitivity in ovarian cancer would be helpful for improving patients’ quality of life and clinical outcomes. HRDetect, utilized to characterize patients’ homologous recombination repair deficiency, was used to predict patients’ response to platinum-based chemotherapy. However, whether each of the single features contributing to HRD score is associated with platinum sensitivity remains elusive.Methods: We analyzed the whole-exome sequencing data of 196 patients who received platinum-based chemotherapy from the TCGA database. Genetic features were determined individually to see if they could indicate patients’ response to platinum-based chemotherapy and prognosis, then integrated into a Pt-score employing LASSO regression model to assess its predictive performance.Results and discussion: Multiple genetic features, including bi-allelic inactivation of BRCA1/2 genes and genes involved in HR pathway, multiple somatic mutations in genes involved in DNA damage repair (DDR), and previously reported HRD-related features, were found to be stringently associated with platinum sensitivity and improved prognosis. Higher contributions of mutational signature SBS39 or ID6 predicted improved overall survival. Besides, arm-level loss of heterozygosity (LOH) of either chr4p or chr5q predicted significantly better disease-free survival. Notably, some of these features were found independent of HRD. And SBS3, an HRD-related feature, was found irrelevant to platinum sensitivity. Integrated all candidate markers using the LASSO model to yield a Pt-score, which showed better predictive ability compared to HRDetect in determining platinum sensitivity and predicting patients’ prognosis, and this performance was validated in an independent cohort. The outcomes of our study will be instrumental in devising effective strategies for treating ovarian cancer with platinum-based chemotherapy.
Clinical severity classes in COVID-19 pneumonia have distinct immunological profiles, facilitating risk stratification by machine learning
Authors: Wiffen Laura , D’Cruz Leon Gerard , Brown Thomas , Higenbottam Tim W. , Bernstein Jonathan A. , Campbell Courtney , Moellman Joseph , Ghosh Debajyoti , Richardson Clive , Weston-Davies Wynne , Chauhan Anoop J. 
Published: September 2023

ObjectiveClinical triage in coronavirus disease 2019 (COVID-19) places a heavy burden on senior clinicians during a pandemic situation. However, risk stratification based on serum biomarker bioprofiling could be implemented by a larger, nonspecialist workforce.MethodMeasures of Complement Activation and inflammation in patientS with CoronAvirus DisEase 2019 (CASCADE) patients (n = 72), (clinicaltrials.gov: NCT04453527), classified as mild, moderate, or severe (by support needed to maintain SpO2 &gt; 93%), and healthy controls (HC, n = 20), were bioprofiled using 76 immunological biomarkers and compared using ANOVA. Spearman correlation analysis on biomarker pairs was visualised via heatmaps. Linear Discriminant Analysis (LDA) models were generated to identify patients likely to deteriorate. An X-Gradient-boost (XGB) model trained on CASCADE data to triage patients as mild, moderate, and severe was retrospectively employed to classify COROnavirus Nomacopan Emergency Treatment for covid 19 infected patients with early signs of respiratory distress (CORONET) patients (n = 7) treated with nomacopan.ResultsThe LDA models distinctly discriminated between deteriorators, nondeteriorators, and HC, with IL-27, IP-10, MDC, ferritin, C5, and sC5b-9 among the key predictor variables during deterioration. C3a and C5 were elevated in all severity classes vs. HC (p &lt; 0.05). sC5b-9 was elevated in the “moderate” and “severe” categories vs. HC (p &lt; 0.001). Heatmap analysis shows a pairwise increase of negatively correlated pairs with IL-27. The XGB model indicated sC5b-9, IL-8, MCP1, and prothrombin F1 and F2 were key discriminators in nomacopan-treated patients (CORONET study).ConclusionDistinct immunological fingerprints from serum biomarkers exist within different severity classes of COVID-19, and harnessing them using machine learning enabled the development of clinically useful triage and prognostic tools. Complement-mediated lung injury plays a key role in COVID-19 pneumonia, and preliminary results hint at the usefulness of a C5 inhibitor in COVID-19 recovery.