bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Minimalistic and Decentralised Approach to Formation Control for Crowded UUV Swarms Inspired by Fish Schooling
Authors: Wu Xuhang , Deng Xiangyang , Shao Siyang , Zhao Luhua , Yue Shengzhi , Zhang Fumin , Wang Fang , Lin Yuanshan 
Published: May 2023

Abstract
In this paper, we propose a novel approach to formation control for a swarm of unmanned underwater vehicles (UUVs) inspired by the collective behaviour of fish schools. The approach addresses the challenges of centralised control, inflexibility, and high computational complexity in existing formation control methods. The proposed strategy for an individual agent consists of three parts: (1) coordinated strategy of collective motion without a predefined target, in which each individual agent adjusts its motion by rotating a fixed angle to the left or right based on the observed motion direction of its neighbours; (2) target guidance policy that the motion direction of each agent is guided by the target area; and (3) dispersion control strategy of avoiding overcrowding near the target area, in which each individual determines its own target position based on the relative positions of its neighbours and the target area. The simulation experiments demonstrate that using the proposed method, a group of individuals can perform an area coverage search in a flexible collective motion manner by simply making a left or right movement based on their own local perception. Furthermore, we validated the effectiveness of the proposed method using a UUV swarm consisting of 9 UUVs in a UUV simulator. The proposed method is flexible, decentralised, and has low computational complexity. Therefore, it can be applied to the formation control of large swarms of UUVs with limited perception and decision-making abilities.
Synthesis of the Solar Heat Reflecting Membrane by Duplicating the Saharan Silver Ant Micro-hair Structure
Authors: Gao Xuefeng , Sun Zhiheng , Ma Jianping , Chen Wenxia , Shang Songmin , Chiu Ka-lok 
Published: May 2023

Abstract
The objective of this project was to use a rolling process to synthesize a solar heat reflecting membrane with parallel-aligned Al-ZnO microrods to replicate the micro-hair arrays of the Saharan Silver Ant. The synthesis of Al-ZnO microrods was carried out using the hydrothermal method. The membrane was then produced by mixing the microrods with liquid silicone rubber and spreading the mixture into the shape of a membrane using a Meyer rod. The dragging of the Al-ZnO microrod, confined between the Meyer rod and the polypropylene film, induces the partial alignment of Al-ZnO microrods in the dragging direction. We note that the distribution of microrod alignment is well described by the Lorentzian function and that the full width at half maximum is measured to be 22.3o. Most Al-ZnO microrods are encased within the PDMS layer. At wavelengths between 200 nm and 1100 nm, the membrane blocks light almost entirely. The solar heat gain coefficient of our solar heat reflecting membrane is 75% lower than the membrane containing ZnO powder.
Adult survivors of childhood-onset steroid-dependent and steroid-resistant nephrotic syndrome treated with cyclosporine: a long-term single-center experience
Authors: Takemasa Yoichi , Fujinaga Shuichiro , Nakagawa Mayu , Sakuraya Koji , Hirano Daishi 
Published: May 2023

Abstract
Background Although evidence has confirmed that cyclosporine A (CsA) is efficacious against childhood-onset steroid-dependent and steroid-resistant nephrotic syndrome (SD/SRNS), some patients may continue to relapse during adulthood. However, predictive factors for active disease into adulthood and renal complications in this cohort remain unknown.Methods We conducted a retrospective study on the long-term outcomes of 81 young adults with childhood-onset SD/SRNS treated with CsA. The primary endpoint was the probability of active disease into adulthood, defined as disease relapse or ongoing immunosuppressive treatment throughout the 2 years preceding the last follow-up.Results At last follow-up (median age, 23.2 years; median disease duration, 15.8 years), 44 adult patients (54%) continued to have active disease, whereas 16 (20%) and 16 (20%) patients developed mild chronic kidney disease (CKD) and hypertension, respectively. Young age at NS onset and history of relapse during initial CsA treatment were independent predictive factors for active disease into adulthood. Acute kidney injury at NS onset, focal segmental glomerulosclerosis, and irreversible CsA nephrotoxicity were identified as risk factors for the development of CKD, whereas older age was identified as a risk factor for the development of renal complications. No correlation was observed between active disease into adulthood and the development of renal complications.Conclusions After CsA initiation for SD/SRNS, more than half of adult survivors continued to have active disease. Long-term follow-up is necessary to identify the development of renal complications later in adulthood that can be attributed to prior disease and CsA treatment in childhood, irrespective of disease activity.
Joint Enhancement and Classification Constraints for Noisy Speech Emotion Recognition
Authors: SUN Linhui , WANG Shun , CHEN Shuaitong , ZHAO Min , LI Pingan 
Published: May 2023

Abstract

In the natural environment, the received speech signal is often interfered by noise, which reduces the performance of speech emotion recognition (SER) system. To this end, a noisy SER method based on joint constraints, including enhancement constraint and arousal-valence classification constraint (EC-AVCC), is proposed. This method extracts multi-domain statistical feature (MDSF) to input the SER model based on joint EC-AVCC using convolution neural network and long short-term memory-attention (CNN-ALSTM). The model is jointly constrained by speech enhancement (SE) and arousal-valence classification (AVC) to get robust features suitable for SER in noisy environment. Besides, in the auxiliary SE task, a joint loss function simultaneously constrains the error of ideal ratio mask and the error of the corresponding MDSF to obtain more robust features. The proposed method does not need to carry out noise reduction preprocessing. Under the joint constraints, it can obtain robust and discriminative deep emotion features, which can improve the emotion recognition performance in noisy environment. The experimental results on the CASIA and EMO-DB datasets show that compared with the baseline, the proposed method improves the accuracy of SER in white noise and babble noise by 4.7%-9.9%.
The value of CT-based radiomics in predicting hemorrhagic transformation in acute ischemic stroke patients without recanalization therapy
Authors: Huang Yin-Hui , Chen Ya-Fang , Cai Chi , Lin You-Yu , Lin Zhi-Qiang , Chen Chun-Nuan , Yang Mei-Li , Wang Yi , Li Yuan-Zhe 
Published: May 2023

Abstract

BackgroundTo investigate the clinical value of radiomics based on non-enhanced head CT in the prediction of hemorrhage transformation in acute ischemic stroke (AIS).Materials and methodsThe radiomic features of infarcted areas on non-enhanced CT images were extracted using ITK-SNAP. The Max-Relevance and Min-Redundancy (mRMR) and the least absolute shrinkage and selection operator (LASSO) were used to select features. The radiomics signature was then constructed by multiple logistic regression. The clinicoradiomics nomogram was constructed by combining radiomics signature and clinical characteristics. All predictive models were constructed in the training group, and these were verified in the validation group. All models were evaluated with the receiver operating characteristic (ROC) curve, calibration curve, and decision curve analysis (DCA).ResultsThe radiomics signature was constructed by 10 radiomics features. The clinicoradiomics nomogram was constructed by combining radiomics signature and atrial fibrillation. The area under the ROC curve (AUCs) of the clinical model, radiomics signature, and clinicoradiomics nomogram for predicting hemorrhagic transformation in the training group were 0.64, 0.86, and 0.86, respectively. The AUCs of the clinical model, radiomics signature, and clinicoradiomics nomogram for predicting hemorrhagic transformation in the validation group were 0.63, 0.90, and 0.90, respectively. DCA curves showed that the radiomics signature performed well as well as the clinicoradiomics nomogram. DCA curve showed the clinical application value of radiomics signature is similar to that of clinicoradiomics nomogram.ConclusionRadiomics signature which was constructed without clinical characteristics can independently predict the hemorrhagic transformation of AIS well.
Nanobodies against SARS-CoV-2 RBD from a Two-step Phage Screening of Universal and Focused Synthetic Libraries
Authors: Chen Fangfang , Liu Zhihong , Kang Wei , Jiang Fan , Yang Xixiao , Yin Feng , Li Zigang 
Published: May 2023

Abstract
Coronavirus disease 2019 (COVID-19) is an evolving global pandemic, and nanobody (Nb) is recognized as a potential diagnostic and therapeutic tool for infectious disease. Here, we designed and synthesized a humanized and highly diverse phage Nbs library hsNb-U (Humanized synthetic Nbs Library - Universal). We expressed and purified the SARS-CoV-2 receptor-binding domain (RBD), and screened this univeral library against the RBD protein target. Then, the CDR1 and CDR2 sequences of five leads obtained from the hsNb-U phage panning were combined with randomly mutated CDR3 to construct a targeted (focused) phage display library, hsNb-RBD, for subsequent phage panning and screening. From the obtained sequences, we expressed 45 unique anti-RBD candidate Nbs. Among the selected Nbs, eight were found to be highly expressed, and five of these show high-affinity to RBD (EC50 less than 100nM). Finally, we found that Nb39 can compete with angiotensin converting enzyme 2 (ACE2) for binding to RBD. Overall, this two-step strategy of synthetic phage display libraries enables rapid selection of SARS-CoV-2 RBD nanobodies with potential therapeutic activity, and this two-step strategy can potentially be used for rapid discovery of Nbs against other targets.
ITC-6102RO, A Novel B7-H3 Antibody-Drug Conjugate, Exhibits Potent Therapeutic Effects against B7-H3 Expressing Solid Tumors
Authors: Shin Seol Hwa , Ju Eun Jin , Park Jin , Ko Eun Jung , Kwon Mi Ri , Lee Hye Won , Son Ga Won , Kim Yeon Joo , Song Si Yeol , Lee Sangkwang , Seo Beom Seok , Song Jin-A , Lim Sangbin , Jung Doohwan , Kim Sunyoung , Lee Hyangsook , Park Seok Soon , Jeong Seong-Yun , Choi Eun Kyung 
Published: May 2023

Abstract
Background
The B7-H3 protein, encoded by the CD276 gene, is a member of the B7 family of proteins and a transmembrane glycoprotein. It is highly expressed in various solid tumors, such as lung and breast cancer, and has been associated with limited expression in normal tissues and poor clinical outcomes across different malignancies. Additionally, B7-H3 plays a crucial role in anticancer immune responses. Antibody-drug conjugates (ADCs) are a promising therapeutic modality, utilizing antibodies targeting tumor antigens to selectively and effectively deliver potent cytotoxic agents to tumors.
Methods
In this study, we demonstrate the potential of a novel B7-H3-targeting ADC, ITC-6102RO, for B7-H3-targeted therapy. ITC-6102RO was developed and conjugated with dHBD, a soluble derivative of pyrrolobenzodiazepine (PBD), using Ortho Hydroxy-Protected Aryl Sulfate (OHPAS) linkers with high biostability. We assessed the cytotoxicity and internalization of ITC-6102RO in B7-H3 overexpressing cell lines in vitro and evaluated its anticancer efficacy and mode of action in B7-H3 overexpressing cell-derived and patient-derived xenograft models in vivo.
Results
ITC-6102RO inhibited cell viability in B7-H3-positive lung and breast cancer cell lines, inducing cell cycle arrest in the S phase, DNA damage, and apoptosis in vitro. The binding activity and selectivity of ITC-6102RO with B7-H3 were comparable to those of the unconjugated anti-B7-H3 antibody. Furthermore, ITC-6102RO proved effective in B7-H3-positive JIMT-1 subcutaneously xenografted mice and exhibited a potent antitumor effect on B7-H3-positive lung cancer patient-derived xenograft (PDX) models. The mode of action, including S phase arrest and DNA damage induced by dHBD, was confirmed in JIMT-1 tumor tissues.
Conclusions
Our preclinical data indicate that ITC-6102RO is a promising therapeutic agent for B7-H3-targeted therapy. Moreover, we anticipate that OHPAS linkers will serve as a valuable platform for developing novel ADCs targeting a wide range of targets.
The correlation between physical activities combined with dietary habits and cardiovascular risk factors among adults in regional China
Authors: Wang Weiwei , Zhou Hairong , Qi Shengxiang , Yang Huafeng , Wang Chenchen , Hong Xin 
Published: May 2023

Abstract
Objectives
The objective of this study was to investigate the correlation between physical activities combined with dietary habits and cardiovascular risk factors in adults from Nanjing, China.
Methods
A representative cohort involving 60 283 participants aged 18 years and older was enrolled by the multistage stratified cluster sampling in Nanjing municipality of China in this cross-sectional survey in 2017. The primary outcomes were the correlation between physical activities combined with dietary habits and cardiovascular risk factors determined by the multivariate logistic regression analysis with adjusted potential confounders. An additive interaction between physical activities and dietary habits was evaluated by calculating the relative excess risk due to interaction (RERI), attributable proportion due to interaction (AP) and synergy index (S).
Results
After adjusting potential confounders, cardiovascular risk factors were significantly correlated with the combination of physical inactivity and unhealthy diet, with the highest odds ratios (ORs) for low density lipoprotein-cholesterol (HLDL-c) (1.64, 95% CI [1.47, 1.84]) and hypertension (1.55, 95% CI [1.46, 1.64]). Additive interactions between physical inactive inactivity and unhealthy diet were found in on cardiovascular risk factors of hypertension (S, 1.46; 95% CI [1.12, 1.89]), type 2 diabetes (T2D) (S, 1.96; 95% CI [1.23, 3.13]), higher low-density lipoprotein-cholesterol (HLDL-c) (S, 2.57; 95% CI [1.27, 5.21]) and dyslipidemia (S, 1.69; 95% CI [1.08, 2.66]). Their RERI was 0.17 (95% CI [0.06, 0.28]), 0.22 (95% CI [0.09, 0.35]), 0.39 (95% CI [0.18, 0.60]) and 0.11 (95% CI [0.03, 0.19]), respectively. OR of being hypertension, T2D, HLDL-c and dyslipidemia in participants of physical inactivity and unhealthy diet was 11%, 15%, 24% and 8.3%, respectively. Multiplicative interaction was detected in obesity, hypertension T2D and HLDL-c.
Conclusion
Both unhealthy diets and physical inactivity were significantly correlated with cardiovascular risk factors. Moreover, there was an additive interaction between physical inactivity combined with unhealthy diet and hypertension, T2D, HLDL-c and dyslipidemia. In conclusion, sufficient physical activities or healthy diet habits are an important protective factor for cardiovascular events, especially their combination.
Does response lag affect travelers’ stated preference? Evidence from a real-time stated adaptation survey
Authors: Fujiwara Keishi , Varghese Varun , Chikaraishi Makoto , Maruyama Takuya , Fujiwara Akimasa 
Published: May 2023

Abstract
Stated preference (SP) surveys typically ask respondents to make a choice under a hypothetical situation. However, the choice context is often unrealistic, leading to errors and biases in the response. To overcome this, revealed preference (RP) data has been used to create a more realistic choice context for generating SP questions. For instance, in stated adaptation (SA) surveys, users are asked to answer SP questions based on a specific RP context they actually experienced. One challenge in SA surveys is that it is difficult for the respondents to precisely recall the RP context, especially when there is a longer time gap between RP behavior and SP response (response lag). However, no empirical studies have been conducted to test how elicited preferences vary in response to changes in the response lag. This study empirically examines the impact of response lag on SP responses using real-time SA survey data collected from Kumamoto and Hiroshima, Japan. To accomplish this, we developed a survey tool that enables respondents to answer SP questions in real time, i.e., immediately after their RP behavior. The empirical results confirmed that systematic bias increases with an increase in response lag. Additionally, the results showed that the greater the response lag, the more respondents tended to focus on the SP attributes rather than the RP attributes. These findings indicate that the timing of responses is an important survey design parameter when conducting a SA survey.
Transcranial transmission ultrasound allows for reliable non-invasive exclusion of intracranial hypertension in traumatic brain injury patients
Authors: Krieg Sandro M. , Schwendner Maximilian , Kram Leonie , Zhang Haosu , Liang Raimunde , Negwer Chiara , Tetschke Florian , Meyer Bernhard 
Published: May 2023

Abstract
Background
Non-invasive measurement of intracranial pressure (ICP) has failed for decades. Yet, it would allow for proper evaluation of unconscious patients suffering from non-penetrating traumatic brain injury (TBI). Transcranial transmission ultrasound (TTUS) measurements provided promising experimental data via brain pulsatility. This study investigates its potential for the detection of elevated ICPs via machine learning-based analysis.
Methods
Patients with severe TBI and invasive ICP monitoring were prospectively enrolled in our intensive care unit. ICP, arterial blood pressure, heart rate and TTUS measurements were simultaneously recorded in situations with and without elevated ICP. A classification model was implemented based on measurements derived from 9 patients with 387 episodes of increased ICP (> 15 mmHg) and 345 episodes of normal ICP (< 10 mmHg). The model was validated in a leave-one-subject-out procedure.
Results
25 patients aged 61·6 ± 17·6 years were enrolled from October 2021 to October 2022. 279 data sets with a mean ICP of 11·3 mmHg (1st quartile 6·1 mmHg; 3rd quartile 14·8 mmHg) were acquired and analyzed. Automated analysis of the TTUS measurements successfully identified increased ICP values > 15 mmHg with a sensitivity 100% and a specificity 47%. A negative predictive value of 100% was achieved, the positive predictive value was 14% for the test set.
Conclusions
TTUS can precisely exclude elevated ICP in TBI patients with a negative predictive value of 100%. Despite low specificity, exclusion of raised ICP can already partially identify patients in the field requiring immediate imaging and potentially neurosurgical intervention. Worth mentioning, this is the very first approach achieving such a high reliability.
Efficacy of Dietary Arginine: Lysine Ratio on Cardiometabolic and Nephrological Hypertension Transcriptional Marker in Wistar Rats
Authors: Vallabha Vishwanath Singanodi , Kumar Varun , Sukhdeo Shinde Vijay , Tiku Purnima Kaul 
Published: May 2023

Abstract
The research looked at the effects of high arginine and high lysine on the expression of transcriptional cardiometabolic indicators and nephrological hypertension markers in Wistar rats. Hypertensive Wistar rats were administered diets supplemented with two dietary amino acids, arginine and lysine. Biochemical indicators, as well as molecular indicators of vasodilator, nephrotoxic, and lipid-lowering, were studied. After 6 weeks of supplementing with high arginine (HA), the group's systolic blood pressure dropped by 25.0 mmHg. The effects of high arginine and high lysine treatment were measured using mRNA of vasodilator markers nephrotoxic markers, and lipid-lowering markers in Wistar rats. Our findings show that dietary supplementation with high arginine reduces nephrotoxicity and influences the metabolic pathways of cardiometabolic markers, hypercholesterolemia markers, and high lysine markers. Hypertension is the multifactorial ailment that affects over one billion individuals, cardiovascular disease, roughly one-third of world population, and chronic kidney disease (CKD) is an ignored medical basis of resistant hypertension with roughly 490 million CKD patients. In our present investigation, we hypothesise a profound effect of the dietary amino acids, arginine, and lysine, on hypertension, nephrotoxicity, and hypercholesterolemia. Hypercholesterolemia would result from an increase in lysine in the hepatic indicators of cholesterol, fatty acids, and TAG homeostasis. The high arg: lys ratio has a prominent influence in the effective regulation of the hypertension molecular markers in combating systolic blood pressure and controlling the hypercholesterolemia, and biomarkers of renal impairment recovery.
Microbial profile, antibiotic sensitivity pattern and empirical antibiotic therapy in acute cholecystitis. A Retrospective observational study
Authors: Xu Liming , Xu Yingge , Wang Tianpeng , Zhou Shengang , Jiang Chengxing , Zheng Yueliang , Cai Wenwei , Pan Yixiang , Wang Ziguang 
Published: May 2023

Abstract
Background
In moderate or severe acute cholecystitis, effective antibiotic therapy is important. We aimed to analyze microorganisms isolated from the bile of patients treated with percutaneous transhepatic gallbladder drainage and their antibiotic susceptibility patterns to assess empirical antibiotic therapy in patients with acute cholecystitis.
Methods
A retrospective descriptive study of clinical data from patients with acute cholecystitis treated with PTGBD at Zhejiang Provincial People's Hospital from January 2020 to December 2022.
Results
Totally, 127 patients' clinical data were collected. 82 patients yielded positive for bile culture and 16 patients yielded positive for blood bacterial culture for at least 1 organism. A total of 124 microorganisms were isolated 19 bacterial and 1 fungal species. Escherichia coli (31.7%), Klebsiella pneumoniae (24.4%), Enterococcus faecium (8.9%), and Enterococcus faecalis(5.6%) were the most frequently isolated pathogenic organisms. Drug sensitivity studies have shown that Gram-negative bacteria are less susceptible to quinolones and cephalosporins, while Gram-positive bacteria are more resistant to erythromycin, and Streptomycin. Long-term nursing home stays are a risk factor for the generation of drug-resistant bacteria.
Conclusions
Escherichia coli, Klebsiella pneumoniae, and enterococcus are common causative agents of acute cholecystitis and they are highly resistant to clinically used antibiotics such as quinolones, cephalosporins, erythromycin, and Streptomycin. Empirical antibiotic use should cover both gram-negative and gram-positive bacteria, with triple-cephalosporins in combination with beta-lactamase inhibitors, carbapenem antibiotics such as imipenem and ertapenem preferred, and may be downgraded when the source of infection is controlled. Nursing facility patients should be aware of multi-drug-resistant bacteria.