bluuebunny/crossref_metadata_2025_split huggingface dataset:
SPRR3 as a diagnostic and prognostic molecular marker for lung adenocarcinoma based on pan-cancer analysis
Authors: yang yanhui , Wang YuChen , Zeng Xiaofei , Li Ji , Luo Lei , Cheng Xin , Xie Xiaoyang 
Published: May 2023

Abstract

Proline-rich small repeat protein 3 (SPRR3) belongs to proline-rich protein family. For exploring SPRR3 expression and its prognostic value in various malignant tumors, we used multiple sets of biomedical information, especially SPRR3 gene level comparison within the pan-cancer. The different immune cell infiltration in pan-cancer is correlated with its specific biological function, molecular characteristics, diagnostic value and prognostic value. Meanwhile, this work further examined correlation between the SPRR3 expression in lung adenocarcinoma and the molecular biology function. Pan-cancer analysis results on 33 malignant tumors showed that SPRR3 was differentially expressed within diverse cancers, which predicted the dismal prognostic outcome of various malignant tumors. At the same time, SPRR3 is associated with immune infiltrating cells in lung adenocarcinoma. The ROC curve and survival curve suggested that SPRR3 had high accuracy in predicting cancer and may be the potential biomarkers used to diagnose and predict prognosis of cancer. Collectively, SPRR3 is the significant biomarker used to diagnose and predict pan-cancer prognosis. High SPRR3 expression independently predicted prognosis of lung adenocarcinoma, which may become a promising molecular cancer therapy target in the future.
Single incision extra-corporeal appendectomy compared to conventional multi-ports appendectomy: a case control study
Authors: Alsafran Salman , AlQabandi Omar , Albloushi Dalia , Baba Mahdi , Aldalal Shuaib , Quttaineh Danah , Alfawaz Abdullah , Alkhamis Ahmed 
Published: May 2023

Abstract
Introduction:
Single incision extra-corporeal appendectomy (SIEA) has emerged as an alternative to the conventional three port appendectomy (CLA). In this study we aim to demonstrate that single incision extracorporeal appendectomy (SIEA) is noninferior to conventional laparoscopic appendectomy (CLA) and more cost effective.
Methods and procedures:
The following study is a retrospective case-control study of patients who underwent either SIEA or CLA. Data obtained from both groups was analyzed in terms of demographics, comorbidities, symptoms, laboratory findings, Alvarado score, imaging findings, American society of Anesthesia (ASA) score, operative time, intraoperative findings, case performance by surgeon level, and outcomes as well as cost. Wilcoxon test was used to compare continuous data. Fischer’s exact test compared proportions. Significance was defined as p-value < 0.05.
Results
A total of 156 patients (27 SIEA vs. 129 CLA) were reviewed. SIEA and CLA were similar in mean age, gender, comorbidities, laboratory investigations, Alvarado score, image positivity, ASA score, and intraoperative findings (p > 0.05 for all). Outcomes were similar between the two groups with regards time to advancement of diet (median time 6 hours vs 6 hours), post-operative complications (wound infection, deep seated infections 3.7% vs 4.7%), and readmission rates (3.7% vs 2.3%) (p > 0.05 for all). Length of stay was slightly shorter in the SIEA than the CLA group, despite approaching statistical significance it was not clinically significant (mean 1.7 days vs 2 days p = 0.05). Operative time in SIEA was shorter than CLA (median time 50 min vs 75 min, (p < 0.001). When considering equipment cost, SIEA had a lower cost compared to CLA (mean cost 236 USD vs 632 USD).
Conclusion
SIEA is noninferior to CLA in terms of outcomes, however it is associated with at least 63% reduction in cost.
The Relationship between Advertising and Consumption
Authors: Wang Tong , Gambaro Marco 
Published: May 2023

Abstract
This paper investigates the relationship between advertising and consumption with panel data at the industry level for some European countries. At the macroeconomic level, consumption can increase only if saving decreases. However, the competition effect of advertising is better captured at the industry level, which allows for interaction between firms. We explore possible relationships with a unique dataset of consumption and advertising spending in 27 sectors across 9 years for 5 European Union countries. Our results show that consumption has a significant in uence on advertising, but the reverse does not apply. Our findings also suggest that business stealing is the dominant effect of advertising relative to consumption increasing.
Ribosome biogenesis: a major player in the exosome of gastric cancer
Authors: Lv Chunyan , Cheng Xian-kui , Zhong Yuan , Jian You-li , He Ming-ming , Lei Tao 
Published: May 2023

Abstract

Objective To identify of vital genes in the blood exosome related to the process of gastric carcinogenesis and help to reduce mortality rates through early diagnosis and the development of new anticancer therapies. Methods: The RNAs data of blood exosomes from patients with GC and healthy controls were downlinked from exoRBase database, and the differential expression of messenger RNA (mRNA), long non coding RNA (lncRNA), and circular RNA (circRNA) were analyzed using R language. Then the relevant RNAs and their corresponding miRNA data predicted by ENCORI, miRcode and other databases, were imported into the ceRNA network. Finally, the DAVID was accessed to investigate the DEmRNAs’ GO annotations and KEGG analysis. Results: A total of 62 mRNAs, 3 lncRNAs and 15 circRNAs were differentially expressed. The ceRNA network was constructed with Cytoscape software, including 192 mRNA nodes, 32 lncRNA nodes, 28 circRNA nodes, and 152 miRNA nodes, with the top 10 hub genes EMSY, ZEB2, LCOR, MFSD14A, ERBIN, hsa-miR-363-3p, hsa-miR-137, hsa-miR-27a-3p, hsa-miR-23b-3p and hsa_circ_0000038. According to GO annotation, the biological processes mainly in cytoplasmic translation, the cell component were mostly in the ribosome and its subunit and the major molecular functions included structural constituent of ribosome, etc. The KEGG revealed that the DEmRNA were primarily enriched in mRNA monitoring pathway. Conclusion: A ceRNA network in the blood exosome of GC were built, the hub genes were screened out, the biological process, cell component, molecular function and enrichment pathway of DEmRNA were explored, which proved that the ribosome biogenesis was a major player in the exosome of gastric cancer and this provide precise targets for making a diagnosis and giving treatment of GC.
Evaluating the relationship of vegetation dynamics with Rainfall and Land Surface Temperature using geospatial techniques in South Wollo zone, Ethiopia
Authors: Meshesha Kindu Setalem , Adem Eshetu Shifaw , Kassaye Ashenafi Yimam , Tsehayu Mulat Amare , Eshetu Amogne Asfaw , Agegnehu Habtamu Wondem 
Published: May 2023

Abstract
Vegetation cover changes persistently over time in reaction to climate variability and changes happen at time scales extending from seasons to a long time and indeed decades. Climate conditions, such as temperature and precipitation variability and biological instability influence vegetation status and vice versa. This study was conducted in the South Wollo zone to assess vegetation dynamics and their relationship with rainfall and land surface temperature. To that end, 16-day 250-meter resolution Moderate Imaging Spectro-radiometer (MODIS) Normalized difference vegetation Index (NDVI), 5-kilometer resolution MODIS Land Surface Temperature (LST), 5-kilometer CHIRPS data were used. A Mann-Kendall (MK) trend test was used to determine the trend of each dataset using seasonal and annual time series. In addition, the Pearson correlation coefficient was used to estimate the relationship between NDVI and climatic elements. The results of the study revealed that there was no significant change in the annual and seasonal rainfall and LST during the period 2000 to 2021, except LST in the autumn season (p = 0.01) and NDVI was significant only in the mean annual (p = 0.027) and summer seasons (p = 0.03). The correlation between NDVI and rainfall was positive (r = 0.84, 0.78, 0.72 & 0.79) and obtained for the summer, autumn, winter, and spring season respectively. Similarly, the correlation between NDVI and LST was negative (r= -0.79, -0.75, -0.72, and − 0.78) in the summer, autumn, winter, and spring seasons respectively. On the other hand, the correlation between annual NDVI with annual RF was positive (r = 0.79) and annual LST was negative (r= -74). The outcome of the study indicates precipitation is the most significant factor in the distribution of vegetation and vegetation greenness constraints LST distribution in the South Wollo Zone. Therefore, the study concluded that vegetation growth is affected by the amount of rainfall and in turn, vegetation cover affects land surface temperature. Vegetation dynamics are not only determined by climate variability but are also affected by topography, slope, soil moisture, and other factors should be considered.
WITHDRAWN: Effective symbiosis and activation of protective antioxidant systems for increasing soybean tolerance to drought
Authors: Nyzhnyk Tetiana , Kiedrzyński Marcin , Kiedrzyńska Edyta , Kots Sergii , Zalewski Maciej 
Published: May 2023

Abstract

Background and Aims
In the face of increasing drought associated with a warming climate, encouraging rhizobial symbioses represents a promising Nature-Based Solution for providing legume crops with ecological nitrogen and increasing drought resistance. In addition, to effectively resist drought, plants must adapt under stress and activate key systems for antioxidant protection.
The aim of the present study is to explore the role of protective antioxidant systems in the drought resistance of soybean, depending on the effectiveness of forming a symbiotic interaction with the nodula bacteria Bradyrhizobium japonicum.
Methods
The study uses microbiological, biochemical, physiological approaches and employs various symbiotic soybean systems based on Bradyrhizobiumstrains and Tn5 mutants, differing in activity and virulence.
Results
The effective symbiotic systems are able to activate the key antioxidant enzymes superoxide dismutase and catalase under prolonged drought, thus maintaining the prooxidant-antioxidant balance of plants and the functioning of the symbiotic relationship under stress conditions. The less effective and ineffective symbiotic systems are unable to provide the soybean plants with antioxidant protection due to the significant development of drought-related oxidative processes, as evidenced by excessive production of hydrogen peroxide and intensification of lipid peroxidation.
Conclusion
The formation of a tolerant soybean-rhizobial symbiosis is the result of the combined ability of both partners, i.e. the macro- and microsymbiont, to realize their adaptive potential and regulate redox homeostasis under effects of drought. This is achieved by activating key antioxidant enzyme systems, thus maintaining the prooxidant-antioxidant status of the symbiotic system.
Comprehensive geriatric assessment predicts listing for kidney transplant in patients with end-stage renal disease: a retrospective cohort study
Authors: Patel Jay , Martinchek Michelle , Mills Dawson , Hussain Sheraz , Kyeso Yousef , Huisingh-Scheetz Megan , Rubin Daniel , Landi Andrea J. , Cimeno Arielle , Madariaga Maria Lucia L. 
Published: May 2023

Abstract
Background: Comprehensive geriatric assessment (CGA) involves a formal broad approach to assess frailty and creating a plan for management. However, the impact of CGA and its components on listing for kidney transplant in older adults has not been investigated.
Methods: We performed a single-center retrospective study of patients with end-stage renal disease who underwent CGA during kidney transplant candidacy evaluation between 2017 and 2021. All patients ≥ 65 years old and those under 65 with any team member concern for frailty were referred for CGA, which included measurements of healthcare utilization, comorbidities, social support, short physical performance battery, Montreal Cognitive Assessment (MoCA), and Physical Frailty Phenotype (FPP), and estimate of surgical risk by the geriatrician.
Results: Two hundred and thirty patients underwent baseline CGA evaluation; 58.7% (135) had high CGA (“Excellent” or “Good” rating for transplant candidacy) and 41.3% (95) had low CGA ratings (“Borderline,” “Fair,” or “Poor”). High CGA rating (OR 8.46; p<0.05), greater number of CGA visits (OR 4.93; p=0.05), younger age (OR 0.88; p<0.05), higher MoCA scores (OR 1.17; p<0.05), and high physical activity (OR 4.41; p<0.05) were all associated with listing on transplant waitlist.
Conclusions: The CGA is a useful, comprehensive tool to help select older adults for kidney transplantation. Further study is needed to better understand the predictive value of CGA in predicting post-operative outcomes.
Investigating the effect of simultaneous implementation of breathing and movement exercises on the ability of lungs to expand in patients with chest tube: a quasi- experimental study
Authors: Rooddehghan Zahra , Arman Alireza , Nasrabadi Alireza Nikbakht , Davari Hamid Reza , Haghani Hamid , Karimi Raoofeh 
Published: May 2023

Abstract
Background
Insertion of chest tube can lead to many complications in lung cancer patients who have undergone lung surgery. Since non-pharmacological measures such as breathing and movement exercises can be a suitable alternative to drug therapy, this study was conducted to investigate the effect of simultaneous implementation of breathing and movement exercises on the ability of lungs to expand in patients with chest tubes after lung cancer surgery.
Methods
This study is a quasi-experimental study that was conducted on 80 participants who had been divided into two groups (n = 40 each). At first, the information related to spirometry values was gathered from the patient's file, and then the amount and characteristics of secretions accumulated in the chest tube bottle, and also the time of chest tube removal were recorded daily. Before removing the chest tube, a spirometry test was performed once again. Patients in the intervention group received the breathing and movement exercises after the surgery. Data collection was done by a researcher-made questionnaire. The collected data were analyzed by SPSS software version 16, using inferential statistics.
Results
A statistically significant difference was observed between two groups in terms of the amount of lung secretions after the interventions. Also, no significant difference was observed between the two groups in terms of the mean scores of spirometry values.
Conclusion
Since performing breathing and movement exercises simultaneously had a positive effect on the ability of lungs to expand.
Trial registration numbers:
The protocol of this clinical trial has been registered in the Iranian Clinical Trial Registration Center (registration code: IRCT20190427043397N1). Registered 26 July 2019- Retrospectively registered, https://www.irct.ir/.
Entrepreneurial Traits Among Teachers and Owners of the Institutional Schools: an Explanatory Sequential Mixed Methods Study
Authors: Neupane Sagar Mani , Bhattarai Prakash C. , Lowery Charles L. 
Published: May 2023

Abstract

The paper presents findings from a study that explores and understands the personal attributes of educational entrepreneurship. The study employs a sequential mixed methods design, administering a survey followed by a case study to collect data from private higher secondary school owners and teachers of the Lalitpur District, Nepal. The survey results revealed the need for achievement, ambiguity tolerance, enthusiasm, creativity/innovation, locus of control, risk-taking propensity, and creativity/innovation as the six personal attributes of educational entrepreneurs. Among the attributes, creativity/innovation contributed significantly to becoming an entrepreneur. The follow-up qualitative study findings revealed that universities must focus on the creativity and innovation of students and revolve around instructing students on the theory of entrepreneurship. By merging qualitative and quantitative results, the study concludes that a person seeking innovation in their profession is more likely to choose entrepreneurship as a career option.
Typha Laxmannii (Typhaceae) in Ukraine: Current Distribution, Еcological and Coenotic Pecularities, Invasiveness
Authors: Shevera Myroslav , Orlov Oleksandr , Dziuba Tetiana , Baranovskyi Boris , Karmyzova Lina , Ivanko Irina , Nikolayeva Valeria , Stotska Olga 
Published: May 2023

Abstract

The results of complex investigations ofTypha laxmanniiLepech (Typhaceae) in Ukraine are presented. The information on the history and modern distribution of the species, its ecological and phytocoenotic peculiarities are summarized. It is a perennial herbaceous plant, alien species of Asian origin which is characterized by a progressive type of range in the country. For the first time in the flora of UkraineT. laxmannii(under the nameT. stenophyllaFisch. ex Mey.) was recorded in 1902 in the south of Ukraine (Kherson Oblast) by Paczosky. Maps of distribution of the species was prepared on the basis of Ukrainian Herbaria, literature sources and electronic databases. Distribution took place in the northern, eastern and western directions as a hydrochore and anemochore. Now the species is distributed almost throughout Ukraine, but with a majority of records in the central and western parts of Ukraine. The associationTyphetum laxmanniiformed by this species is common for Ukraine. Depending on the ecological and geographical conditions and floristic composition, 3 following variants in this association were identified: var.typica,var.T. latifola,and var.Schoenoplectus lacustris. Coenoses within this association are distributed almost throughout the whole territory of Ukraine, but the ecological optimum of the species coenotic area is observed in the South of the country, in the Steppe zone, on slightly saline, well-watered substrates. Based on studies conducted in Zhytomyr Oblast in 1995–2021, the expansion rate ofT. laxmanniiwas calculated – from the South to the North – in average 16.6±1.09 km·year-1. From the sites of the primary penetration of the species into the region (Forest-Steppe zone), the expansion rate of it toward to the North was significantly lower (7.7–9.0 km·year-1) compared to that in the Forest zone – Ukrainian Polissia (23.4–31.9 km·year-1).
Antifibrotic effect of disulfiram on bleomycin-induced lung fibrosis in mice
Authors: Okabe Yugo , Toda Etsuko , Urushiyama Hirokazu , Terashima Yuya , Kunugi Shinobu , Kajimoto Yusuke , Terasaki Mika , Matsushima Kouji , Saito Akira , Yamauchi Yasuhiro , Nagase Takahide , Shimizu Akira , Terasaki Yasuhiro 
Published: May 2023

Abstract

Macrophage accumulation in the lung tissue during inflammation is important in the pathogenesis of fibrotic lung disease. Deficiencies in chemokine receptors CCR2 and CCR5 and their ligands, which mediate monocyte/macrophage migration, ameliorate bleomycin (BLM)-induced lung fibrosis. Disulfiram (DSF)—used as a drug for alcoholism because of its aldehyde dehydrogenase (ALDH)-inhibiting effect—inhibits monocyte/macrophage migration by inhibiting FROUNT, an intracellular regulator of CCR2/CCR5 signaling. To examine DSF’s antifibrotic effect on BLM-induced lung fibrosis in mice and its impact on macrophage response, oral DSF administration’s effects on lung fibrosis and macrophage infiltration were evaluated in a BLM-induced lung fibrosis mouse model. The DSF direct inhibitory activity on monocyte migration was measured in a Boyden chamber assay and compared with DSF-related inhibitors with different FROUNT-inhibition activities. Quantitative PCR determined the expression of fibrosis-promoting genes in the lung tissue. DSF suppressed macrophage infiltration into the lung tissue and significantly attenuated BLM-indued lung fibrosis. DSF and DSF metabolites, diethyldithiocarbamate (DDC) and copper diethyldithiocarbamate (Cu(DDC)2), inhibited monocyte migration toward the culture supernatant fluid of primary mouse lung cells comprising mainly CCL2, whereas cyanamide—another ALDH inhibitor—did not. DSF, with higher inhibitory activity against FROUNT than DDC and Cu(DDC)2, inhibited monocyte migration most strongly. In BLM-induced fibrotic lung tissues, profibrotic factors were highly expressed but were reduced by DSF treatment. These results suggest DSF inhibited macrophage infiltration probably by a FROUNT-mediated mechanism and attenuated BLM-induced lung fibrosis. DSF therapy as drug repositioning can be practical and feasible for treating fibrotic lung diseases, including idiopathic pulmonary fibrosis.
Predictive Factors for Shunt Dependency in Patients with Spontaneous Intraventricular Hemorrhage
Authors: Li Chi-Ruei , Yen Chun-Ming , Yang Meng-Yin , Cheng Wen-Yu , Shen Chiung-Chyi , Liu Szu-Yuan 
Published: May 2023

Abstract

Intraventricular hemorrhage (IVH) occurs in approximately 30–50% patients with spontaneous intracerebral hemorrhage (ICH), with a high 30-day mortality rate. Excess accumulation of parenchymal or ventricular blood associated with the development of acute hydrocephalus leads to poor outcomes. The prediction of shunt dependency is important to identify patients susceptible to requiring permanent shunt placement and benefit from the diversion. This retrospective analytical study aimed to establish a predictive model of shunt dependency in patients with IVH. This study included 179 patients with primary IVH with supratentorial origin or spontaneous ICH with extension into the ventricles between 2015 and 2021. Patients were grouped into “shunt required” and “shunt not required” groups. Variables, including age, sex, preexisting hypertension and diabetes, initial Glasgow Coma Scale scores, ICH location and volume, urokinase administration, modified Graeb score (mGraeb score), and bicaudate index, were analyzed. The shunt required group had significantly higher mGraeb scores (12.0 (6.5–15.0) vs. 7.0 (4.0–12.0), p = 0.001) and higher bicaudate index (0.20 (0.17–0.23) vs. 0.16 (0.13–0.18), P < 0.001) than the shunt not required group. The receiver operating characteristic curve (ROC curve) analysis revealed that a cut-off value of 0.16 of the bicaudate index was significantly related to shunt dependency. The subgroup statistical analysis revealed that neither urokinase administration (p = 0.533) nor urokinase dosage (p = 0.117) showed significant relevance in shunt dependency in patients who received external ventricular drainage. In logistic regression adjusted for the confounders, thalamic ICH (odds ratio (OR) 3.55; 95% confidence interval [(95%CI), 1.13–11.18], an mGraeb score greater than 8 (OR, 3.93; 95%CI, 1.84–8.38), and a bicaudate index greater than 0.16 (OR, 9.87; 95%CI, 3.79–25.73) were factors associated with a higher tendency for shunting. The findings of this study may help identify patients at risk for a permanent shunt after IVH.