bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prospective evaluation of return to work, health-related quality of life and psychosocial distress after radical cystectomy: 1-year follow-up in 230 employed German bladder cancer patients
Authors: Müller Guido , Butea-Bocu Marius Cristian , Beyer Burkhard , Tully Karl Heinrich , Berg Sebastian , Roghmann Florian , Noldus Joachim , Bahlburg Henning 
Published: September 2023

Abstract
Purpose
To evaluate return to work (RTW), health-related quality of life (HRQoL) and psychosocial distress (PD) after radical cystectomy (RC) and creation of an ileal conduit (IC) or an orthotopic ileal neobladder (NB) for bladder cancer.

Methods
The study relied on prospectively collected data for 842 patients, who underwent 3 weeks of inpatient rehabilitation (IR) after surgery between April 2018 and December 2019. HRQoL (EORTC QLQ-C30) and PD (Questionnaire on Stress in Cancer Patients [QSC-R10]) were evaluated at the beginning (T1) and end (T2) of IR as well as both 6 (T3) and 12 months after surgery (T4). Regression analyses were performed to identify predictors of HRQoL and RTW, respectively.

Results
Two hundred thirty patients (IC n = 51, NB n = 179) were employed before surgery (27.3%). HRQoL improved steadily, while high PD was present in 51.0% of patients at T4. RTW rate was 86.8 and 80.6% at T3 and T4, respectively. Linear regression analysis identified RTW as the only predictor for better HRQoL at T4 (OR [odds ratio] 12.823, 95% CI [confidence interval] 2.927–22.720, p = 0.012). Multivariate regression analysis identified age ≤ 59 years (OR 7.842; 95% CI 2.495–24.645; p < 0.001) as an independent positive predictor and lymph node metastasis (OR 0.220; 95% CI 0.054–0.893; p = 0.034) as an independent negative predictor of RTW at T4.

Conclusion
Global HRQoL improved steadily during the follow-up and RTW rates are high. However, patients often reported high PD, reflecting a need for additional psychosocial support within aftercare.
Geographic longitude in Latin Europe during the twelfth and thirteenth centuries
Authors: Nothaft C. Philipp E. 
Published: September 2023

AbstractThis article surveys surviving evidence for the determination of geographic longitude in Latin Europe in the period between 1100 and 1300. Special consideration is given to the different types of sources that preserve longitude estimates as well as to the techniques that were used in establishing them. While the method of inferring longitude differences from eclipse times was evidently in use as early as the mid-twelfth century, it remains doubtful that it can account for most of the preserved longitudes. An analysis of 89 different estimates for 30 European cities indicates a high degree of accuracy among the longitudes of English cities and a conspicuous displacement eastward (by 5°–7;30°) shared by most longitudes of cities in Italy and France. In both cases, the data suggest a high level of interdependence between estimates for different cities in the same geographic region, although the means by which these estimates were arrived at remain insufficiently known.
Novel algorithms for improved detection and analysis of fluorescent signal fluctuations
Authors: Stopper Gebhard , Caudal Laura C. , Rieder Phillip , Gobbo Davide , Stopper Laura , Felix Lisa , Everaerts Katharina , Bai Xianshu , Rose Christine R. , Scheller Anja , Kirchhoff Frank 
Published: September 2023

AbstractFluorescent dyes and genetically encoded fluorescence indicators (GEFI) are common tools for visualizing concentration changes of specific ions and messenger molecules during intra- as well as intercellular communication. Using advanced imaging technologies, fluorescence indicators are a prerequisite for the analysis of physiological molecular signaling. Automated detection and analysis of fluorescence signals require to overcome several challenges, including correct estimation of fluorescence fluctuations at basal concentrations of messenger molecules, detection, and extraction of events themselves as well as proper segmentation of neighboring events. Moreover, event detection algorithms need to be sensitive enough to accurately capture localized and low amplitude events exhibiting a limited spatial extent. Here, we present two algorithms (PBasE and CoRoDe) for accurate baseline estimation and automated detection and segmentation of fluorescence fluctuations.
Prevalence of mutations in common tumour types in Northern England and comparable utility of national and international Trial Finders
Authors: Rae S. , Plummer E. , Fitzgerald L. , Hogarth L. , Bridgewood A. , Brown-Schofield L. , Graham J. , Haigh S. , McAnulty C. , Drew Y. , Haris N. , Bashir S. , Plummer R. , Greystoke A. 
Published: September 2023

Abstract
Purpose
Tumour genomic profiling is of increasing importance in early phase trials to match patients to targeted therapeutics. Mutations vary by demographic group; however, regional differences are not characterised. This was investigated by comparing mutation prevalence for common cancers presenting to Newcastle Experimental Cancer Medicine Centre (ECMC) to The Cancer Genome Atlas (TCGA) and utility of trial matching modalities.

Methods
Detailed clinicogenomic data were obtained for patients presenting September 2017–December 2020. Prevalence of mutations in lung, colorectal, breast and prostate cancer was compared to TCGA GDC Data Portal. Experimental Cancer (EC) Trial Finder utility in matching trials was compared to a Molecular Tumour Board (MTB) and commercial sequencing reports.

Results
Of 311 patients with advanced cancer, this consisted of lung (n = 131, 42.1%), colorectal (n = 44, 14.1%), breast (n = 36, 11.6%) and prostate (n = 18, 5.6%). More than one mutation was identified in the majority (n = 260, 84%). Significant prevalence differences compared to TCGA were identified, including a high prevalence of EGFR in lung (P = 0.001); RB1 in breast (P = 0.0002); and multiple mutations in prostate cancer. EC Trial Finder demonstrated significantly different utility than sequencing reports in identifying trials (P = 0.007).

Conclusions
Regional differences in mutations may exist with advanced stage accounting for prevalence of specific mutations. A national Trial Finder shows utility in finding targeted trials whilst commercial sequencing reports may over-report ‘actionable’ mutations. Understanding local prevalence and trial availability could increase enrolment onto matched early phase trials.
Influence of axis misalignments in stepped planetary gear stages on the excitation behavior—test rig development and simulative analysis
Authors: Westphal Christian , Brimmers Jens , Brecher Christian 
Published: September 2023

AbstractOne challenge in the design of automotive gearboxes is the combination of high power density, high efficiency and low noise emission. With the electrification of the powertrain, the requirements in terms of noise emission and efficiency increase additionally. Stepped planetary gear stages are a potential topology to solve the current challenges in gearbox technology. Current research shows the pronounced misalignment behavior of planetary gear stages, especially with manufacturing or assembly deviations. However, the effects of dynamic misalignment behavior on tooth contacts in stepped planetary gear stages have not been adequately investigated. This paper presents a test rig that allows the investigation of the excitation and displacement behavior of stepped planetary gear stages taking into account adjustable axis misalignments. The axis misalignment of the stepped planetary shafts is introduced with eccentric bushings in this test rig concept. To evaluate the excitation and displacement behavior the transmission error and the displacements of different components can be measured. The test rig is modeled in the dynamic multibody simulation. The tooth contact is modeled using the force module GearForce6D. The axis misalignment is varied in the simulation model and the influence on the excitation and displacement behavior is evaluated. The simulation results show that planet pin position errors have the highest influence on the sun trajectory and the load sharing. The misalignments occurring in the tooth contacts due to inclination and skew of the stepped planetary shaft lead to higher tooth flank pressures and an increase in the total transmission error.
Can mobile health apps with smartphones and tablets be the new frontier of cognitive rehabilitation in older individuals? A narrative review of a growing field
Authors: Maggio Maria Grazia , Luca Antonina , Calabrò Rocco Salvatore , Drago Filippo , Nicoletti Alessandra 
Published: September 2023

AbstractIntroductionA recent interesting field of application of telemedicine/e-health involved smartphone apps. Although research on mHealth began in 2014, there are still few studies using these technologies in healthy elderly and in neurodegenerative disorders. Thus, the aim of the present review was to summarize current evidence on the usability and effectiveness of the use of mHealth in older adults and patients with neurodegenerative disorders.MethodsThis review was conducted by searching for recent peer-reviewed articles published between June 1, 2010 and March 2023 using the following databases: Pubmed, Embase, Cochrane Database, and Web of Science. After duplicate removal, abstract and title screening, 25 articles were included in the full-text assessment.ResultsTen articles assessed the acceptance and usability, and 15 articles evaluated the efficacy of e-health in both older individuals and patients with neurodegenerative disorders. The majority of studies reported that mHealth training was well accepted by the users, and was able to stimulate cognitive abilities, such as processing speed, prospective and episodic memory, and executive functioning, making smartphones and tablets valuable tools to enhance cognitive performances. However, the studies are mainly case series, case–control, and in general small-scale studies and often without follow-up, and only a few RCTs have been published to date.ConclusionsDespite the great attention paid to mHealth in recent years, the evidence in the literature on their effectiveness is scarce and not comparable. Longitudinal RCTs are needed to evaluate the efficacy of mHealth cognitive rehabilitation in the elderly and in patients with neurodegenerative disorders.
Science, Not Black Magic: Metal and Glass Production in Africa
Authors: Bandama Foreman , Babalola Abidemi Babatunde 
Published: September 2023

AbstractOngoing research continues to show that ancient Africans had their own versions of science that were embedded in local contexts. The apparent lack of writing systems in most of the continent, especially south of the Sahara, was used to undermine the continent’s scientific achievements. Rather than relegate Africa to a simple receiver of science and technology, ancient Africans should be celebrated for their successful improvisation and experimentation. We discuss processes of metal and glass production in western and southern Africa to reveal key aspects of the scientific method in these ancient African technologies and situate the knowledge within an appreciation of inclusive education that embraces diverse ideas and practices of science and technology.
Dynamics of Cell Death Due to Electroporation Using Different Pulse Parameters as Revealed by Different Viability Assays
Authors: Peng Wencheng , Polajžer Tamara , Yao Chenguo , Miklavčič Damijan 
Published: September 2023

AbstractThe mechanisms of cell death due to electroporation are still not well understood. Recent studies suggest that cell death due to electroporation is not an immediate all-or-nothing response but rather a dynamic process that occurs over a prolonged period of time. To investigate whether the dynamics of cell death depends on the pulse parameters or cell lines, we exposed different cell lines to different pulses [monopolar millisecond, microsecond, nanosecond, and high-frequency bipolar (HFIRE)] and then assessed viability at different times using different viability assays. The dynamics of cell death was observed by changes in metabolic activity and membrane integrity. In addition, regardless of pulse or cell line, the dynamics of cell death was observed only at high electroporation intensities, i.e., high pulse amplitudes and/or pulse number. Considering the dynamics of cell death, the clonogenic assay should remain the preferred viability assay for assessing viability after electroporation.
Process-based evaluation of adsorbents: effect of CMS pellet size on N2-PSA performance
Authors: Marcinek A. , Guderian J. 
Published: September 2023

AbstractThe process-based evaluation of adsorbents is considered the most foolproof method with respect to a particular application, as it provides data about the separation effectiveness in authentic operating conditions. This paper presents empirically obtained performance results of the kinetically-controlled air separation on multiple carbon molecular sieves carried out in a twin-bed pressure swing adsorption unit. The effect of adsorbent pellet size on nitrogen productivity and air demand is studied at different product purity levels (10–10,000 ppm O2 of the residual oxygen concentration), operating temperatures (25–45 °C), and half-cycle times (35–70 s). The selected process conditions correspond to the majority of practical applications. Guidelines for the suitable particle size depending on the desired nitrogen purity are given.
Emotion Regulation, Parenting, and Psychopathology: A Systematic Review
Authors: Zitzmann Jana , Rombold-George Larissa , Rosenbach Charlotte , Renneberg Babette 
Published: September 2023

AbstractThe presence of a parental mental disorder can lead to adverse outcomes for children. Difficulties in emotion regulation are observed across a range of mental health problems and may play a crucial role in this context. Following PRISMA guidelines, we systematically searched Medline, PsycINFO, Embase, and Web of Science for studies examining the association between emotion regulation in parents with psychopathology at a clinical or subclinical level and their parenting. The protocol was registered with the PROSPERO international prospective register of systematic reviews (CRD42021224954; January 2021). A total of 23 studies were included in the qualitative synthesis. Emotion regulation was predominantly assessed using self-report on the general ability (e.g., Difficulties in Emotion Regulation Scale). The assessment of parenting encompassed a broad range of aspects and operationalizations. Across psychopathology in parents, several aspects of difficulties in emotion regulation were associated with unfavorable emotion socialization, more negative parenting, and partially with less positive parenting. Slightly different effects were observed for posttraumatic stress disorder and anxiety disorders. For parents with depressive disorders, specific emotion regulation strategies (suppression, reappraisal) seem to buffer against negative parenting. Since the majority of studies refer only to mothers, generalization to fathers is limited. Furthermore, conclusions are limited due to study heterogeneity and lack of prospective studies. Nevertheless, findings suggest that interventions should target the improvement of emotion regulation in parents with psychopathology.
Liquid Biopsy in Low-Grade Glioma: A Systematic Review and a Proposal for a Clinical Utility Score
Authors: Zanin Luca , Sachkova Alexandra , Panciani Pier Paolo , Rohde Veit , Fontanella Marco Maria , Schatlo Bawarjan 
Published: September 2023

AbstractLiquid biopsy research on Low-Grade gliomas (LGG) has remained less conspicuous than that on other malignant brain tumors. Reliable serum markers would be precious for diagnosis, follow- up and treatment. We propose a clinical utility score (CUS) for biomarkers in LGG that mirrors their clinical usefulness. We conducted a PRISMA review. We examined each biomarker classifying them by CUS and Level of Evidence (LOE). We identified four classes of biomarkers: (1). Circulating protein—(a) vitronectin discriminates LGG from HGG (Sn:98%, Sp:91%, CUS: 3, LOE: III), (b) CTLA-4 discriminates LGG from HGG, (cutoff: 220.43 pg/ml, Sn: 82%, Sp: 78%, CUS:3, LOE:III), (c) pre-operative TGF b1 predict astrocytoma (cutoff: 2.52 ng/ml, Sn: 94.9%, Sp: 100%, CUS:3, LOE:VI). (2). micro-RNA (miR)—(a) miR-16 discriminates between WHO IV and WHO II and III groups (AUC = 0.98, CUS:3, LOE: III), (b) miR-454-3p is higher in HGG than in LGG (p = 0.013, CUS:3, LOE: III), (c) miR-210 expression is related to WHO grades (Sn 83.2%, Sp 94.3%, CUS: 3, LOE: III). (3). Circulating DNA—(a) IDH1R132H mutation detected in plasma by combined COLD and digital PCR (Sn: 60%, Sp: 100%, CUS: 3, LOE: III). 4. Exosomes—(a) SDC1 serum levels could discriminate GBM from LGG (Sn: 71%, Sp: 91%, CUS: 2C, LOE: VI). Our investigation showed that miRs appear to have the highest clinical utility. The LOE of the studies assessed is generally low. A combined approach between different biomarkers and traditional diagnostics may be considered.
Graphical Abstract
We identified four main classes of biomarkers produced by LGG. We examined each biomarker, classifying them by clinical utility score (CUS) and level of evidence (LOE). Micro-RNA (miRs) appears to have the highest CUS and LOE.
A new diatom-based multimetric index to assess lake ecological status
Authors: Tison-Rosebery J. , Boutry S. , Bertrin V. , Leboucher T. , Morin S. 
Published: September 2023

AbstractEutrophication impairs lake ecosystems at a global scale. In this context, as benthic microalgae are well-established warnings for a large range of stressors, particularly nutrient enrichment, the Water Framework Directive required the development of diatom-based methods to monitor lake eutrophication. Here, we present the diatom-based index we developed for French lakes, named IBDL (Indice Biologique Diatomées en Lacs). Data were collected in 93 lakes from 2015 to 2020. A challenge arose from the discontinuous pressure gradient of our dataset, especially the low number of nutrient-impacted lakes. To analyze the data we opted for the so-called “Threshold Indicator Taxa ANalysis” method, which makes it possible to determine a list of “alert taxa.” We obtained a multimetric index based on specific pressure gradients (Kjeldahl nitrogen, suspended matter, biological oxygen demand, and total phosphorous). Considering the European intercalibration process, the very good correlation between IBDL and the common metric (R2 from 0.52 to 0.87 according to the lake alkalinity type) makes us very confident in our ability to match future IBDL quality thresholds with European standards. The IBDL proved at last to be particularly relevant as it has a twofold interest: an excellent relationship with total phosphorus (R2 from 0.63 to 0.83 according to the lake alkalinity type) and a possible application to any lake metatype. Its complementarity with macrophyte-based indices moreover justifies the use of at least two primary producer components for lake ecological status classification.
An investigation of online and offline learning models for online Just-in-Time Software Defect Prediction
Authors: Cabral George G. , Minku Leandro L. , Oliveira Adriano L. I. , Pessoa Dinaldo A. , Tabassum Sadia 
Published: September 2023

AbstractJust-in-Time Software Defect Prediction (JIT-SDP) operates in an online scenario where additional training data is received over time. Existing online JIT-SDP studies used online Oza ensemble learning methods with Hoeffding Trees as base learners to learn and update JIT-SDP models over time in this scenario. However, it is unknown how these approaches compare against offline learning approaches adapted to operate in online scenarios, and how the use of any other online or offline base learners would affect online JIT-SDP in terms of predictive performance and computational cost. We therefore propose a new approach called Batch Oversampling Rate Boosting (BORB) that is able to use offline base learners in an online JIT-SDP scenario. Based on 10 open source projects, we provide a comprehensive evaluation of BORB with 5 different base learners and the existing online approach Oversampling Rate Boosting with 4 different base learners, both in within-project and cross-project online JIT-SDP scenarios. The results show that offline learning can lead to better predictive performance than the top performing online learning approaches considered in our study, at a higher computational cost. Cross-project data was helpful to improve predictive performance both for offline and online learning, but especially for online learning.
Geo-environmental factors controlling groundwater hydrogeochemistry, salinization and quality in El Qaa plain coastal aquifer, Southwest Sinai, Egypt
Authors: Salman Salman A. , El-Anwar Esmat A. Abou , Aita Sami K. , Elnazer Ahmed A. 
Published: September 2023

AbstractEl Qaa plain is one of the promising areas for agriculture projects, owing to its soil and groundwater resources. So, 14 groundwater samples were collected, chemically analyzed, hydrochemical (ratios, models and plots) and GIS techniques were applied, to evaluate the factors governing this water chemistry and suitability for irrigation. The results indicated the expansion of the agricultural area 8 times in the last 2 decades. The water can be divided into two groups; (A) freshwater (TDS ≤ 1000) in the eastern part of the study area within the clastic weathered basement rocks part of the aquifer, and (B) saline water (TDS > 1000) in the western part within the carbonates and evaporites rich sediments and close to the Gulf of Suez. The deduced factors controlling groundwater chemistry were precipitation, evaporites dissolution, seawater intrusion and ion exchange process. The calculated sodium absorption ratio (SAR) was < 10 indicating the good quality of this water for irrigation without sodicity hazard. Water of Group (A) (electric conductivity < 2250µS/cm) can be used safely for irrigation without any impact of salinity on all types of soil and plants. Group (B) water (electric conductivity > 2250µS/cm) has salinity hazard and can be used for irrigation on well-permeable soils and salt-tolerant plants. The concentrations of the studied potentially toxic elements (PTEs) were within the permissible limit for irrigation. Expansion in agricultural activities has adverse impact on groundwater quality. So, eco-friendly fertilizers should be applied in this promising area with the application of hydrologic pumping advises to safe aquifer quality from the degradation.