bluuebunny/crossref_metadata_2025_split huggingface dataset:
Smart money or chasing stars: Evidence from northbound trading in China
Authors: Liao Cunfei , Tang Guohao , Xu Xiaoying 
Published: December 2022

AbstractTo explore what kinds of roles foreign investors take in a gradually opening financial market, we propose the abnormal holding value ratio (AHVR) of northbound investors among stocks through China's Stock Connect Mechanism. We find that AHVR positively predicts the expected stock returns and significantly relates to firms' quality‐related fundamental information, especially profitability. Foreign investors learn the firm fundamentals before they invest in the Chinese market, which is different from the trading behaviour of domestic individual investors. The AHVR premium is larger among firms with higher attention of analysts who focus on effective information and with lower attention of individual investors who have behavioural bias. In all, the northbound inflows are smart money, which will increase the efficiency of the Chinese market instead of simply chasing stars that only grab investors' attention.
How does the stock market affect the interest rate corridor system in China?
Authors: Wan Jing , Zhang Shen , Feng Xu 
Published: December 2022

AbstractExogenous shocks from the stock market may contribute to fluctuations in market‐based interest rates in China. The interaction between the two markets may go beyond an aggregate level to distributional aspects. By using the cross‐quantilogram method, we characterise how China's stock market affects its retail credit market in distribution. Our results show clearly which quantile ranges in the stock market influence tail events in the retail credit market. We also offer practical advice on potential upper and lower bounds of the interest rate corridor. Furthermore, the main results still hold even with the foreign exchange market or the benchmark interest rate being controlled. Based on this, we provide pertinent policy suggestions for China's ongoing transition to the interest rate corridor system.
The role of receptor‐mediated activities of 4‐ and 5‐ring unsubstituted and methylated polycyclic aromatic hydrocarbons (PAHs) in developmental toxicity
Authors: Fang Jing , Wang Danlei , Kramer Nynke I. , Rietjens Ivonne M. C. M. , Boogaard Peter J. , Kamelia Lenny 
Published: December 2022

AbstractThe present study evaluated the aryl hydrocarbon receptor (AhR), estrogen receptor‐α (ER‐α), and retinoic acid receptor (RAR) mediated activities of nine 4‐ and 5‐ring unsubstituted and monomethylated polycyclic aromatic hydrocarbons (PAHs) using a series of Chemical‐Activated LUciferase gene eXpression (CALUX) assays. The potential role of these aforementioned receptors in relation to the developmental toxicity of these PAHs was further assessed in the zebrafish embryotoxicity test (ZET). The results show that all nine tested PAHs were AhR agonists, benz[a]anthracene (BaA) and 8‐methyl‐benz[a]anthracene (8‐MeBaA) were ER‐α agonists, and none of the tested PAHs induced ER‐α antagonistic or RAR (ant)agonistic activities. In the AhR CALUX assay, all the methylated PAHs showed higher potency (lower EC50) in activating the AhR than their respective unsubstituted PAHs, implying that the addition of a methyl substituent on the aromatic ring of PAHs could enhance their AhR‐mediated activities. Co‐exposure of zebrafish embryos with each individual PAH and an AhR antagonist (CH223191) counteracted the observed developmental retardations and embryo lethality to a certain extent, except for 8‐methyl‐benzo[a]pyrene (8‐MeBaP). Co‐exposure of zebrafish embryos with either of the two estrogenic PAHs (i.e., BaA and 8‐MeBaA) and an ER‐α antagonist (fulvestrant) neutralized embryo lethality induced by 50 μM BaA and the developmental retardations induced by 15 μM 8‐MeBaA. Altogether, our findings suggest that the observed developmental retardations in zebrafish embryos by the PAH tested may partially be AhR‐ and/or ER‐α‐mediated, whereas the RAR seems not to be relevant for the PAH‐induced developmental toxicity in the ZET.
Current status of interprofessional competency among healthcare professions in Japan: A cross‐sectional web‐based survey
Authors: Goto Ryohei , Haruta Junji 
Published: December 2022

AbstractBackgroundSelf‐assessment of professionals' interprofessional competency is meaningful for benchmarking oneself and helping to identify training needs. We aimed to clarify differences in self‐assessment of interprofessional competency in Japan by profession and type of facility.MethodsWe conducted a cross‐sectional study using a web survey among primary healthcare providers in Japan, especially members of the Japan Primary Care Association, between June and October 2020. After sampling using the e‐mail list, we used an exponential nondiscriminative snowball method as purposive sampling through key professional informants between November 2020 and February 2021. The questionnaire covered items including participant demographics (age, gender, years of experience as professionals, years of experience working at the current institution, attendance type (regular or part‐time work), administrative experience, profession, and facility type) and included the Japanese version of the Self‐assessment Scale of Interprofessional Competency (JASSIC). Differences between healthcare professions (physician, nurse, pharmacist, rehabilitation therapist, and social worker) and between types of facility (university hospital, medium‐sized hospital, small hospital, and clinics) were compared using the Kruskal–Wallis test.ResultsA total of 593 people responded to the survey. Their mean age was 41.2 ± 11.3 years, and 312 (52.6%) were female. JASSIC scores of physicians and social workers were significantly higher than those of rehabilitation therapists (p < 0.01). Concerning facilities, professionals working in clinics rated themselves higher than those in medium‐sized hospitals (p < 0.01).ConclusionsWe revealed that self‐assessment of interprofessional competency in Japan varied by profession and type of facility.
Yeast or water: producing wine with lower alcohol levels in a warming climate: a review
Authors: Xynas Billy , Barnes Chris 
Published: December 2022

AbstractClimate change effects over the last century have seen grape wine growers being faced with earlier budburst and shorter seasons. One effect is higher sugar levels in the grape berries, resulting in wines with higher than typical alcohol concentrations. Winemakers, both in Australia and globally, need to reassess their wine making approaches to address the challenges associated with warmer drier conditions. This review focuses on two pre‐fermentation approaches that address ethanol production during fermentation, so that wine makers can produce a wine with lower final alcohol levels at the same time as addressing any negative impacts on wine quality. First, microbiological yeast approaches are reviewed. This approach can reduce final alcohol levels in a treated wine between 0.2% v/v‐3.7% v/v; however, diverse wine quality impacts can result, dependant on the microbiological yeast approach taken. Second, the pre‐fermentation approach of water addition/substitution into a high sugar grape must is reviewed. To date, recent studies indicate that this ‘water treatment’ of musts approach is effective with respect to reducing final alcohol levels from between 0.6% v/v‐5.9% v/v in the resultant wines, with less variation effects on final wine quality. It is noted that further studies for the ‘water treatment’ of high sugar musts approach are required to provide additional foundational data sets with respect to impacts on chemical, phenolic and sensory attributes of the final wine products, both within and across vintages. This is especially important as winemakers adapt their winemaking approaches in a changing climate. © 2022 Society of Chemical Industry.
Current Status and Perspectives on the Green Synthesis of Succinic Polyesters for Value‐Added Applications
Authors: Gucker Fernando Elias , Sayer Claudia , de Oliveira Débora , Hermes de Araújo Pedro H. , Oechsler Bruno Francisco 
Published: December 2022

AbstractPolybutylene succinate (PBS) and other succinic (co)polyesters are biodegradable polymers with favorable mechanical and thermal properties that find use in many applications. Due to environmental concerns, polymers based on succinic acid (SA) have been gaining attention, as SA can be produced through biotechnological processes. Thus, this review aims to highlight the synthesis and characteristics of PBS and other succinic copolyesters, with emphasis in the works employing metallic catalysts and enzymes. In addition, the modification of the macromolecular structure by copolymerization or postpolymerization is also discussed. Currently, metallic catalysts are normally used in the synthesis of these materials, under conditions of high temperatures, which can favor the occurrence of thermal degradation, increasing the dispersion of chain length distributions. Moreover, the incrustation of metallic catalysts in polymeric materials makes their application in biomedical products difficult, due to toxicity requirements. In this context, enzymatic catalysis is gaining ground, offering milder synthesis temperatures, high selectivity, and uniformity of synthesized products. This biotechnological route can substitute oligomerization processes with metallic catalysis in future industrial processes, producing materials free from metallic contamination. In addition to production by catalytic routes, trends for future applications of succinic (co)polyesters are presented, with emphasis on the value‐added materials sectors.
Enhancing the adsorption affinity of cellulose acetate film toward cationic dye by incorporating Cloisite 30B grafted with polyacrylic acid
Authors: Kandil Heba , Moghazy Reda M. , Amin Amal 
Published: December 2022

AbstractCellulose acetate (CA) is known for its low adsorption affinity toward dyes, hence this study aims to improve its adsorption affinity toward cationic dyes by introducing Cloisite 30B grafted with polyacrylic acid (C30B‐g‐PAA). C30B‐g‐PAA was synthesized by grafting polyacrylic acid (PAA) onto Cloisite 30B (C30B) using in‐situ reversible addition fragmentation chain transfer (RAFT) polymerization. Different weight ratios of unmodified (raw) and modified (C30B‐g‐PAA) C30B (0, 25, and 50 wt%) were incorporated into CA matrices to prepare a series of CA nanocomposite films. The results showed that the adsorption affinity of the prepared nanocomposite films increased toward cationic methylene blue (MB) dye with incorporating either unmodified or modified C30B, but a significant improvement was observed with the incorporating C30B‐g‐PAA with a maximum adsorption capacity of 53 mg/g for a load of 50 wt%. This indicates that the surface modification of C30B with PAA was effective in enhancing the adsorption efficacy of CA. The kinetic and isotherm studies showed that the adsorption behavior of CA nanocomposite film with 50 wt% of C30B‐g‐PAA followed pseudo‐second‐order and Langmuir isothermal model. Regeneration study showed good reusability of CA nanocomposite film with 50 wt% of C30B‐g‐PAA. These results demonstrate that the nanocomposite film with 50 wt% of C30B‐g‐PAA can be used as a highly efficient, easy to separate, and reusable adsorbent material to remove MB dye from wastewater.
Selective somatostatin receptor 5 inhibition improves hepatic insulin sensitivity
Authors: Tamura Yumiko Okano , Sugama Jun , Abe Shin‐ichi , Shimizu Yuji , Hirose Hideki , Watanabe Masanori 
Published: December 2022

AbstractDiabetes is a metabolic disorder with an increasing global prevalence. Somatostatin (SST), a peptide hormone, regulates hormone secretion via five SST receptor (SSTR) subtypes (SSTR1–5) in a tissue‐specific manner. As SSTR5 is expressed in pancreatic β‐cells and intestinal L‐cells, studies have suggested that SSTR5 regulates glucose tolerance through insulin and incretin secretion, thereby having a prominent role in diabetes. Moreover, SSTR5 knockout (KO) mice display enhanced insulin sensitivity; however, the underlying mechanism has not been clarified. Therefore, in this study, we investigate the effect of SSTR5 blockade on insulin resistance and the target organ using SSTR5 KO mice and a selective SSTR5 antagonist (compound‐1). High‐fat diet (HFD)‐fed SSTR5 KO mice exhibited significantly lower homeostasis model assessment of insulin resistance (HOMA‐IR) than HFD‐fed wild‐type mice. Two‐week oral administration of compound‐1 dose‐dependently and significantly reduced changes in the levels of glycosylated hemoglobin (GHb), plasma glucose, plasma insulin, and HOMA‐IR in male KK‐Ay/Ta Jcl mice (KK‐Ay mice), a model of obese type 2 diabetes with severe insulin resistance. Additionally, compound‐1 significantly increased the glucose infusion rate while decreasing hepatic glucose production in male KK‐Ay mice, as evidenced by hyperinsulinemic‐euglycemic clamp analyses. In addition, compound‐1 ameliorated the insulin‐induced Akt phosphorylation suppression by octreotide in the liver of male C57BL/6J mice. Collectively, our results demonstrate that selective SSTR5 inhibition can improve insulin sensitivity by enhancing liver insulin action; thus, selective SSTR5 antagonists represent potentially novel therapeutic agents for type 2 diabetes.
Partial analysis increments as diagnostic for LETKF data assimilation systems
Authors: Diefenbach Theresa , Craig George , Keil Christian , Scheck Leonhard , Weissmann Martin 
Published: December 2022

AbstractLocal ensemble transform Kalman filters (LETKFs) allow explicit calculation of the Kalman gain, and by this the contribution of individual observations to the analysis field. Though this is a known feature, the information on the analysis contribution of individual observations (partial analysis increment) has not been used as systematic diagnostic up to now despite providing valuable information. In this study, we demonstrate three potential applications based on partial analysis increments in the regional modelling system of Deutscher Wetterdienst and propose their use for optimising LETKF data assimilation systems, in particular with respect to satellite data assimilation and localisation. While exact calculation of partial analysis increments would require saving the large, five‐dimensional ensemble weight matrix in the analysis step, it is possible to compute an approximation from standard LETKF output. We calculate the Kalman gain based on ensemble analysis perturbations, which is an approximation in the case of localisation. However, this only introduces minor errors, as the localisation function changes very gradually among nearby grid points. On the other hand, the influence of observations always depends on the presence of other observations and settings for the observation error and for localisation. However, the influence of observations behaves approximately linearly, meaning that the assimilation of other observations primarily decreases the magnitude of the influence, but it does not change the overall structure of the partial analysis increments. This means that the calculation of partial analysis increments can be used as an efficient diagnostic to investigate the three‐dimensional influence of observations in the assimilation system. Furthermore, the diagnostic can be used to detect whether the influence of additional experimental observations is in accordance with other observations without conducting computationally expensive single‐observation experiments. Last but not least, the calculation can be used to approximate the influence an observation would have when applying different assimilation settings.
The quantum trajectory‐guided adaptive Gaussian methodology in the Libra software package
Authors: Dutra Matthew , Garashchuk Sophya , Akimov Alexey V. 
Published: December 2022

AbstractIn this paper, we report an implementation of the quantum trajectory‐guided adaptive Gaussian (QTAG) method in a modular open‐source Libra package for quantum dynamics calculations. The QTAG method is based on a representation of wavefunctions in terms of a quantum trajectory‐guided adaptable Gaussians basis and is generalized for time‐propagation on multiple coupled surfaces to be applicable to model nonadiabatic dynamics. The potential matrix elements are evaluated within either the local harmonic or bra‐ket‐average (linear) approximations to the potential energy surfaces, the latter being a more practical option. Performance of the QTAG method is demonstrated and discussed for the Holstein and Tully models, which are the standard benchmarks for method development in the area of nonadiabatic dynamics.
Potential approaches to establishing harmonious river‐human relationships
Authors: Greenway John 
Published: December 2022

AbstractThis paper responds to a call to address the development and building of river‐human relationships in the twenty‐first century. Many literatures have identified the historical instrumental exploitation of natural resources underpinning urbanisation and the economic development leading to wide‐spread degradation of environments including rivers. Clearly such relationships can no longer be considered as appropriate in the twenty‐first century. This paper intends to present a conceptual rethink to address the following question: Are there potential approaches by which humans can develop harmonious coexistent relationships with riverine landscapes and associated ecosystems? In answering this question, this paper draws on ideas from new materialism thinking. New materialism offers useful guidance in understanding human‐river relationships in which river landscapes are not static backgrounds to the performance of the social. River systems and environments are active participants influencing and shaping social performances through multiple and diverse interconnected and complex human‐nonhuman relationships and co‐productive partnerships. It is concluded that new materialist perspectives provide important guidance for developing harmonious river‐human relationships. De‐centring the human as the dominant actor in relations with river landscapes and acknowledging rivers as key actors within river‐human relationships may enhance the building of harmonious coexistent and mutually beneficial relationships in the twenty‐first century. It is further concluded the Nature Futures Framework (NFF) and Human‐River Encounter Sites (HRES) frameworks in their capacity to accommodate new materialist thinking provide an opportunity for further exploration and examination of the possibilities for building harmonious coexistent river‐human relationships.
Scoping Review of Medical Students' Perceptions of the Field of Dermatology
Authors: Abdelwahab Rewan , Shahin Ahmad , Kim Yong-hun , Coias Jennifer , Qureshi Muhammad B. , Vidal Nahid 
Published: December 2022

Abstract

Background
Although perceived barriers to applying to dermatology have been researched among medical students, there remains a dearth of literature dedicated to understanding perceptions that medical students have of the field of dermatology and dermatologists.

Methods
A review of the literature in Embase, Pubmed, Scopus, Web of Science, and ScienceDirect were carried out to identify articles and abstracts between 2016 and 2021 relating to medical student perceptions of the field of dermatology. Peer-reviewed English studies measuring attitudes/level of interest in dermatology or other specialities, understanding of dermatologic topics, procedures, and/or scope of practice were included. Duplicate studies and conference abstracts were excluded. All publications were screened using the PRISMA-Sc guidelines. Findings were summarised and tabulated accordingly.

Results
A total of nine articles met inclusion criteria and eight are included in this review since one was not accessible online. Notable findings include non-US medical students perceiving dermatology as monotonous, stigmatized, unfamiliar, and difficult to access with a misunderstanding of the diversity and severity of the conditions dermatologists treat. No data on US medical student perceptions was found. Perceptions were found to be influential in career planning: medical students may reject specialities after exposure to negative comments on the field. Factors attracting students to dermatology include the appeal of being a dermatologist, media portrayal, and dermatologists' influence on patients' lives. Completion of dermatology-related activities improved medical student interest, comfort, and understanding of the field. Early dermatology exposure in US undergraduate premedical students led to heightened interest in the field, more confidence in ability to find dermatology mentors, and increased perception that dermatology serves the needs of underserved communities.

Conclusions
This review demonstrates the need to further investigate medical student perceptions of dermatology, particularly in the United States. Perceptions of medical specialities can impact medical student career choices. Understanding which misconceptions may be preventing students from exploring dermatology can inform efforts towards improving diversity, equity, and inclusion: translating to an equitable match and improving patient outcomes. Limitations include exclusion of articles published before 2016, geographic variability in studies, and limited data on evolving student perceptions over time.
Hexagon AgNCs/PVP Crystallization Induced Cathode Electrochemiluminescence Enhancement for miRNA221 Biosensing
Authors: Wang Bin , Wang Guangjie , Li Jing , Liu Xinling , Ni Nan , Su Huilan , Chen Mei , Mao Li 
Published: December 2022

AbstractAggredation‐induced electrochemiluminescence (AIECL) promises an efficient strategy for synthesize highly luminescent emitter and co‐reactant for ECL analysis, however, rational control of electrogenerated emission intensity is still challenging. The low electroconductivity and amorphous molecular configuration are intrinsic bottleneck. This work reveals the impact of polyvinyl pyrrolidone backbone regulated silver nanocrystallines (AgNCs/PVP) on the cathode AIECL properties in near infrared region, by employing the Box‐Behnken designed response surface computation model to modulate crystal aggregates. Electron paramagnetic resonance spectroscopy discovered hydrogen radical (HO•) dominant reductive‐oxidative (R‐O) ECL mechanism with AgNCs acting as the co‐reaction accelerator in graphene oxide/persulfate system (GO/S2O82−). Both theoretical calculation and experimental measurement testified that the ECL of AgNCs in GO/S2O82− dependent on the concentration of in situ electrochemical oxidized Ag+. The high efficiency of crystallization‐induced enhanced ECL (CIECL) originates from 1) the effective electron transfer of Ag+ accelerated HO• produce to notable promote radioactive transition, and 2) twisted intramolecular charge transfer from the electron‐rich donor of PVP to electron‐deficient receptor of Ag0 to restrict nonradioactive transition. The AgNCs/PVP with CIECL effect are applied to construct an ultrasensitive platform for miR‐221 assay with a lower detection limit of 7.47 × 103 copies mL−1 than typical qPCR method.