bluuebunny/crossref_metadata_2025_split huggingface dataset:
Case Report: A Migrating Stitch in a Crohn’s Disease Patient
Authors: Abenavoli Ludovico , Spagnuolo Rocco , Corea Alessandro , Boccuto Luigi , Gambardella Marialuisa , Procopio Anna Caterina , Luzza Francesco 
Published: February 2023

Background:
More than half of Crohn’s disease (CD) patients undergo one or more surgical interventions during their lifetime. The main surgical indications for CD are fistulas and stenosis and other emergency conditions such as megacolon and perforation. The risk of CD recurrence at the surgery site is high.

Case Presentation:
Here, we report the case of a migrating suture stitch that moved from the abdomen
to the subcutaneous tissue of the thigh in a CD patient having undergone intestinal surgery
years before.

Results:
To the best of our knowledge, there are no previously reported cases of migrating stitches, especially in CD. However, CD is a disease at high risk of surgery due to its clinical characteristics and complications.

Conclusion:
In the most doubtful cases, it is advisable to co-operate in a multidisciplinary perspective to provide the patient with the best management.
Sericin: From Cocoons as a Raw Material to Cosmetics
Authors: Gholap Anjali , Radhalakshmi Yalagalawadi Channaiah , Das Brojeswari , Rangi Abhilasha , Rastogi Rachna 
Published: February 2023

Background:
Sericin is a hydrophilic and adhesive protein that provides structural integrity to
the silkworm cocoon.

Objective:
The study aimed to develop sericin isolated from Indian BV mulberry silk cocoons as a cosmetic
raw material and study its sensory impact.

Methods:
Sericin was isolated using high-temperature and high-pressure techniques without the use of
chemicals. Native and hydrolyzed sericin were studied for suitability in cosmetic formulations. Lastly,
their safety was established using a primary irritation patch test in twenty-four healthy volunteers, and the
impact of sericin on skin care formulation was studied.

Results:
Both native and hydrolyzed sericin were studied for their application in personal care products.
Native sericin was difficult to process due to its gelling behavior. Hydrolyzed sericin was readily formulated
in skin lotion and was found to be stable for 3 months under accelerated conditions. Sericin and its
formulations did not cause any skin irritation and were found to be well-tolerated. Formulation with
0.01% w/w hydrolyzed sericin was best accepted among the panelists.

Conclusion:
The study establishes the use of sericin isolated from mulberry silkworms as a sensory enhancer
for skin care applications.
Implementasi Pembelajaran Jarak Jauh Menggunakan Microsoft Teams Dimasa Pandemi Covid-19 pada Mata Pelajaran Dasar-Dasar Konstruksi Bangunan dan Teknik Pengukuran Tanah Kelas X DPIB Semester Gasal Tahun Ajaran 2021/2022 di SMK Negeri 2 Wonogiri
Authors: Haryanto Lilik , Murti Maricha Husada 
Published: February 2023

Penelitian ini bertujuan untuk mendeskripsikan implementasi pembelajaran jarak jauh menggunakan Microsoft Teams dimasa pandemi covid-19 pada mata pelajaran Dasar-Dasar Konstruksi Bangunan dan Teknik Pengukuran Tanah kelas X DPIB semester gasal tahun ajaran 2021/2022 di SMK Negeri 2 Wonogiri. Metode penelitian yang digunakan dalam penelitian ini adalah metode deskriptif kuantitatif. Teknik pengumpulan data terdiri dari kuesioner, wawancara, dan dokumentasi. Teknik analisis data menggunakan analisis data statistik deskriptif kuantitatif. Hasil penelitian: (1) kesiapan guru masuk dalam kategori “Baik” dengan skor rerata 93; (2) kesiapan siswa masuk dalam kategori “Hampir Baik” dengan skor rerata 75; (3) kesiapan sarana dan prasarana yang menunjang guru dan siswa masuk dalam kategori “Baik” dengan skor rerata 95 untuk guru dan masuk dalam kategori “Hampir Baik” dengan skor rerata 75 untuk siswa; (4) perencanaan pembelajaran masuk dalam kategori “Baik” dengan skor rerata 96 untuk guru dan masuk dalam kategori “Hampir Baik” dengan skor rerata 80 untuk siswa; (5) pelaksanaan pembelajaran masuk dalam kategori “Baik” dengan skor rerata 88 untuk guru dan masuk dalam kategori “Hampir Baik” dengan skor rerata 77 untuk siswa; (6) evaluasi pembelajaran masuk dalam kategori “Hampir Baik” dengan skor rerata 70 untuk guru dan 77 untuk siswa.
Peran Guru Penggerak Dalam Penguatan Profil Pelajar Pancasila Sebagai Ketahanan Pendidikan Karakter Abad 21
Authors: S.Pd. Dewi Umi Qulsum 
Published: February 2023

ABSTRAK Tujuan penelitian ini adalah untuk mengungkapkan bagaimana peran guru penggerak dalam penguatan profil pelajar Pancasila untuk mewujudkan ketahanan pendidikan karakter pada abad 21 sehingga generasi bangsa Indonesia mampu bersaing secara global. Apa saja yang menjadi hak dan tanggung jawab guru penggerak dalam melaksanakan penguatan profil pelajar Pancasila dalam proses pendidikan. Serta nilai apa saja yang harus dimiliki oleh guru penggerak agar mampu mewujudkan ketahanan pendidikan karakter abad 21.Penelitian ini merupakan penelitian normatif; tahap penelitian studi kepustakaan dan analisis deduktif. Jenis pendekatan penelitian yang digunakan peneliti adalah pendekatan konseptual dan pendekatan perundang-undangan. Penelitian yang dilakukan peneliti membahas mengenai apa saja peran guru dalam upaya menguatkan profil pelajar Pancasila pada siswanya sebagai upaya ketahanan pendidikan karakter abad 21. Peneliti juga menggunakan metode kepustakaan (library research) dan wawancara kepada beberapa guru penggerak.Berdasarkan penelitian yang dilakukan, diketahui bahwa guru penggerak mempunyai peran penting dalam membentuk ketahanan karakter siswanya. Peran penting guru penggerak tersebut yaitu menjadi pemimpin pembelajaran yang mendorong well-being ekosistem pendidikan di sekolah. Guru penggerak juga berperan menggerakkan komunitas belajar (menjadi praktisi komunitas) untuk rekan guru di sekolah dan di wilayahnya, menjadi pengajar praktik (coach) bagi rekan guru lain terkait pengembangan pembelajaran di sekolah. Selain itu guru penggerak juga berperan membuka ruang diskusi positif serta ruang kolaborasi antar guru dan pemangku kepentingan di dalam dan luar sekolah. Tujuannya adalah untuk meningkatkan kualitas pembelajaran, dan mendorong peningkatan kepemimpinan siswa di sekolah.
Designing Futures with Pasts
Authors: Tochtrop Christoph , Jessen Dustin 
Published: February 2023

The impending climate catastrophe gives rise to an increased environmental awareness among many designers, who direct their work towards the paradigm of sustainability. While designing with an ‘ecological lens’ is necessarily oriented towards the future, we highlight the past as an inspiring realm to explore. Rather than recycling materials, we encourage the recycling of ideas as a combination of historiographic and speculative design methods.
We will present a framework that extends the idea of design as a ‘projecting’ activity into the idea of design as a constant negotiation process about the relevance and appropriateness of current and past technologies. Design revolves not just about what will be, but to a large extent about what should remain and what should recur, or as Jan Michl put it: “seeing design as redesign” (Michl 2002).We will illustrate the thought of designing futures with pasts by means of a research project that aims at developing a refrigerator for circular economy. The refrigerator – as the currently dominant technology to preserve food – will serve as a starting point to show how artefacts and architecture as well as human skills and knowledge in the preparation and preservation of food are historically interlinked. The history of food preservation unfolds not only along the evolution of the refrigerator, but encompasses household techniques like smoking, curing and fermenting, as well as long-forgotten architectural ‘answers’ such as deep-freeze community buildings. We will revisit three historical examples of food preservation and present the method ‘throwing’ past ideas into the future.
Three main arguments are presented in this richly illustrated paper: First, that historiography is a form of designing, second, that designing is constituted and influenced by path dependencies (cf. David 1985) that are deeply rooted in the past and third, that the past is a valuable source of inspiration when designing for sustainable development. Looking at history becomes a way of “mental window shopping” (Simon 1985, 188) for approaches that are to be reactivated and transformed.
Digital Imperfection
Authors: Garrido Federico , Samuel Joy , Brum Rodrigo , Schmitt Christian 
Published: February 2023

Digital Imperfection was a temporary installation at the German University in Cairo (GUC) that combined the use of mixed-reality tools and earth as a sustainable and multifaceted material. The project involved two separate processes that came together during the final montage procedure: on the one hand, the design of handmade earth bricks, and on the other, the design of a parametric wall and the coding of the montage procedure on the mixed-reality platform.
The project aimed to reconnect both students and a wider audience with a traditional craft through the use of modern digital tools. Hand-crafted bricks were stacked to create a wall with the help of a HoloLens device, which overlaid a digital four-dimensional model over the physical world. Despite the mediation of digital apparatus, the aim was to engage participants in a comprehensive workflow that involved aspects of both handmade production and interactive assembly, rather than promoting a mere robotic process. During the research phase, we investigated the relationship between high-tech and low-tech tools through the following questions:
• How can we incorporate digital technology without losing human interaction?
• How can we measure and account for manufacturing imperfections?
• How can we minimise those imperfections within the design and its montage?
• What benefits and opportunities are offered by the combination of low- and high-tech techniques?
The process accounted for various imperfections and height irregularities (resulting, for example, from differences in mortar thickness or manufacturing), sustaining a constant loop with real-time feedback: the physical model was updated with new bricks while the digital model was updated with height corrections.
The research offers multiple benefits. Firstly, it introduces students (and a broader academic public) to the use of sustainable materials in combination with parametric design. Secondly, it produces a digitally-designed installation (of relative complexity) without the need for printed documentation. Finally, it demonstrates a resource-saving method in which both building procedure and instructions are entirely virtual, eliminating the need for framework or printed plans.
Digital Imperfection puts humans at the centre of the digital assembly process; humans are not replaced by robots or algorithms but instead collaborate with them in ways that maximise the advantages they offer.
Commoning Landscapes from Home
Authors: Marks Andrew Edward Gordon 
Published: February 2023

The coronavirus pandemic has limited the ability to undertake in situ ethnographic fieldwork. Digital methods have instead proven popular with researchers gathering qualitative data over the course of the pandemic. Digital methods nevertheless present challenges for studies that have traditionally relied upon experiencing landscapes in situ.
This paper traces some of the epistemological, methodological, and ethical shifts that have taken place within my PhD project as a result of the global pandemic. Within my project, I am investigating how contemporary queer communities have established and maintained inclusive and sustainable commons landscapes. Originally, I had envisaged using in situ ethnographic methods to research experiences of commoning landscapes amongst case study queer communities; however, I have instead embraced a queerly scavenged combination of oral history interviewing, autoethnographic methods, and digital community archiving to meet my original research aims.
Within this paper, I highlight how commoning can shift from a research focus to an ethical and methodological approach at times of community precarity. In doing so, I question the resilience of an in situ/remote binary when researching commoning landscapes. I argue that my new research positioning has enabled this research project to lie more clearly within the theoretical tenets of queer and feminist commoning—particularly in destabilising dualistic patterns of thinking. I contend that digital methods can support commoning landscapes; however, I also raise some of the challenges of using digital methods in the context of researching more–than–human landscape ecologies.
This paper adds to the emerging literature that extends feminist new materialisms and queer ecologies towards commons and landscape studies. I ultimately advocate for researchers to not only consider methodological feasibility when in times of crisis, but to reconsider what role the research(er) has in future world–making.
Kualitas sirup berbahan dasar daun pandan wangi
Authors: Deva I Gede Sumalana , Juniarta Pande Putu 
Published: February 2023

Tujuan dari penelitian Kualitas Sirup Berbahan Dasar Daun Pandan Wangi( Pandanus odoratissimus ) adalah untuk membuat sirup lain dari yang sudah ada dan daun pandan mudah dicari di pemukiman masyarakat dan juga banyak manfat dan kasiat dari daun pandan untuk manusia. Dan untuk mengetahui kualitas dari sirup daun pandan wangi berbahan campuran seperti gula, cmc, pewarna, vanili, ekstra pandan, dan air, dan memiliki kualitas rasa, aroma, tekstur dan warna, kemudian untuk mengetahui daya tahan serta menganalisis seberapa besar biaya yang diperlukan dalam pembuatan sirup daun pandan wangi pandanus odoratissimus. Pendekatan penelitian yang digunakan adalah penelitian eksperimen, penelitian eksperimen ini dilakukan dengan membuat sirup daun pandan pandanus odoratissimus, kemudian diuji oleh 20 orang panelis dengan tes organoleptic, observasi dan analisi biaya. Hasil penelitian ini berupa kualitas sirup daunpandan sebagai bahan dasar daun pandan wangi menjadi sirup pandanus odoratissimus adalah enak dari segi rasa, beraroma wangi, testur lembut,serta memiliki kasiat untuk manusi. Dari hasil uji daya tahan sirup daun pandan wangi cepat basi ketika dibuka begitu saja, maka dari itu sirup diletakan ditempat yang dingin. Dari asil analisi biaya dalam pembuatan sirup daun pandan wangi pandanus odoratissimus membutuhkan biaya Rp.45.000

The purpose of the research on the Quality of Syrup Based on Wangi Pandan Leaves (Pandanus odoratissimus) is to make another syrup from the existing one and pandan leaves are easy to find in community settlements and also many benefits and benefits of pandan leaves for humans. And to determine the quality of the fragrant pandan leaf syrup made from a mixture of sugar, cmc, dye, vanilla, extra pandan, and water, and have the quality of taste, aroma, texture and color, then to determine the durability and analyze how much cost is required in making pandanus odoratissimus pandanus leaf syrup. The research approach used is experimental research, this experimental research was conducted by making pandanus odoratissimus pandan leaf syrup, then tested by 20 panelists with organoleptic tests, observation and cost analysis. The results of this study are the quality of pandan leaf syrup as the basic ingredient of fragrant pandan leaves into pandanus odoratissimus syrup, which is delicious in terms of taste, smells good, has a soft texture, and has properties for humans. From the results of the durability test, the fragrant pandan leaf syrup spoils quickly when opened, so the syrup is placed in a cool place. From the results of the cost analysis in the manufacture of fragrant pandan leaf syrup, pandanus odoratissimus costs Rp.45.000
CONTROVERSIAL BEHAVIOR OF POLITICAL ELITES IN INDONESIA DURING THE COVID-19
Authors: Sujoko Anang , Khartimah Khusnul , Masyitah Amalia Dewi , Wahyudi Dicky 
Published: February 2023

The Covid-19 pandemic, which has accounted for remarkable casualties in Indonesia, did not seem to make political elites more empathetic. The study aims to reveal how the mythology of the political elites behind the criticism of Instagram accounts @GejayanMemanggil. To fulfill this goal, we employed Roland Barthes' semiotic analysis of nine contents of @GejayanMemanggil. This study has revealed five major results. First, the mythology of the political elite is represented as the 'ancilus' of oligarchic interests during the Covid-19 pandemic. Second, political elites and oligarchs have superior positions to control society and health workers. Third, the political elites' policies focus more on economic recovery than the people’s safety. Fourth, @GejayanMemanggil Instagram account narrates the mythology of political elites who have no sensitivity towards people’s hardship because they exploit their positions and facilities as public officials. Finally, political elites show that they do not empathize with the suffering of the people during the Covid-19 pandemic.
Self-ligating brackets do not reduce discomfort or pain when compared to conventional orthodontic appliances in Class I patients: a clinical study
Authors: Lopes Gracia Costa , Watinaga Gilson Kazuo , Guimarães Antônio Sérgio , Rocha Valadas Lidia Audrey , Ramacciato Juliana 
Published: February 2023

ABSTRACT

Objectives
To compare the intensity, location, and short-term impact of the periodontal discomfort/pain, as well as the related functional parameters of bite force and masticatory efficiency, between self-ligating and conventional orthodontic appliances.

Materials and Methods
In 20 patients referred for orthodontic treatment, samples were collected from the gingival sulcus to evaluate the level of substance P using enzyme-linked immunosorbent assay. Orthodontic devices were randomly bonded, with self-ligating appliances on one side and conventional brackets on the contralateral side. Pain threshold (PT), maximal bite force (MBF), and masticatory efficiency (ME) were assessed using standard validated techniques at the beginning of the treatment and 24 hours post–orthodontic activation with an 0.016-inch nickel-titanium wire.

Results
There were no significant differences (P &gt; .05) in the substance P levels, PT, MBF, and ME between the self-ligating and conventional orthodontic appliances.

Conclusions
There was no difference between conventional and self-ligating appliances in the parameters of pain: substance P and pressure. Functional aspects, such as pain, discomfort, and masticatory efficiency, should not be considered when making a therapeutic decision regarding the use of self-ligating vs conventional orthodontic appliances.
Studi In-Silico Ekstrak Dalam Tanaman Ranti (Solanum nigrum) Sebagai Inhibitor Jak2 pada Penyakit Leukemia Limfoblastik
Authors: Christine Christine , Pebriani Fathia , Al Faruq Muhammad Ariq , Florencia Carla , Muchtaridi Muchtaridi 
Published: February 2023

Leukemia Limfoblastik Akut (LLA) merupakan penyakit hematologi heterogen yang ditandai dengan proliferasi sel limfoid imatur di sumsum tulang, darah tepi, dan organ lainnya karena adanya mutasi pada reseptor JAK. Beberapa tahun terakhir, strategi baru yang menargetkan protein terkait penyakit untuk degradasi seperti Proteolysis targeting chimerics (PROTAC) diteliti. Penelitian ini bertujuan untuk studi in silico aktivitas senyawa penghambat STAT 3 dan JAK 2 pada tanaman ranti (Solanum nigrum L.). Pengujian dilakukan menggunakan perangkat lunak meliputi, ChemOffice 2019, AutoDockTools 1.5.6., BIOVIA Discovery Studio 2021, dan Ligandscout. Dari 17 senyawa tanaman ranti yang diuji, hanya 11 senyawa yang memenuhi aturan Lipinski rules of five dan prediksi ADMETOKS yang kemudian dilanjutkan dengan penambatan molekul. Hasilnya, senyawa N-Acetyl-L-tryptophan ethyl ester dinilai paling berpotensi sebagai antikanker, meskipun memiliki energi gibbs yang lebih rendah sebesar -6.38 kcal/mol apabila dibandingkan dengan ligan alaminya yakni -8.19 kcal/mol. Hasil menunjukkan tanaman ranti (Solanum nigrum L.) berpotensi sebagai kandidat pengobatan LLA, namun masih butuh penelitian lebih lanjut dengan perangkat lunak yang lebih lengkap.
Interaksi Konstituen Kimia Lada Hitam (Piper nigrum L.) Terhadap Reseptor 5-HT1B Sebagai Antidepresan dengan Pendekatan In Silico
Authors: Sufi Nadia Adhani , Nauroh Judith , Nurani Neng Vera , Nurhaenifah Annida Adha , Harmonis Jacko Abiwaqash , Hidayat Syahrul 
Published: February 2023

Depresi merupakan penyakit yang mempengaruhi perasaan, cara berpikir, dan tindakan. Depresi menyebabkan perasaan sedih dan / hilangnya minat pada suatu aktivitas. Depresi dapat diobati menggunakan antidepresan. Piper nigrum L. atau Lada Hitam merupakan tanaman yang dapat digunakan sebagai antidepresan. Pada lada hitam terkandung senyawa metabolit sekunder yang dapat sebagai antidepresan dengan mekanisme terhadap 5-HT1B. Penelitian ini bertujuan untuk mempelajari interaksi antara senyawa yang terkandung pada lada hitam yang berpotensi sebagai antidepresan terhadap protein 5-HT1B menggunakan metode molecular docking secara in silico. Pengujian dilakukan menggunakan aplikasi Autodock 4.2 untuk simulasi penambatan molekuler, divisualisasi dengan Biovia Discovery Studio 2020 Client, dan analisis hasil farmakokinetika serta toksisitas dari senyawa melalui situs pre-ADMET. Hasil penambatan diperoleh senyawa piperettin memiliki potensi paling besar menjadi kandidat obat antidepresan melalui mekanisme agonis 5-HT1B dibandingkan senyawa uji lainnya karena memiliki energi ikatan sebesar -8,84 kKal/mol dengan ikatan hidrogen pada residu asam amino THR134. Berdasarkan analisis hasil prediksi, Piperettin memiliki sifat farmakokinetika dengan nilai CaCo-2 54,6793; HIA 98,050270% ; PPB 92,408768%. Hasil pre-ADMET senyawa menunjukan adanya dugaan potensi karsinogen.Kata kunci: 5-HT1B, Antidepresan, Molecular Docking, Piperettin, Piper nigrum
Crosstalk between apoptosis and cytotoxic lymphocytes (CTLs) in the course of Lagovirus europaeus GI.1a infection in rabbits
Authors: Niedźwiedzka-Rystwej Paulina , Deptuła Wiesław 
Published: February 2023

Abstract

Introduction

Lagovirus europaeus is a single-stranded RNA virus causing an acute fatal disease in wild and domestic rabbits around the world. Studies have shown that the pivotal process impacting the immune response against the disease is apoptosis, registered mainly in hepatocytes and in peripheral blood, together with an increased number of cytotoxic lymphocytes (CTLs). It is known that cytotoxic lymphocytes can induce target cells to undergo apoptosis on the pseudoreceptor pathway, such apoptosis having been found in several acute and chronic viral infections. The study aimed to assess the crosstalk between the apoptosis of peripheral blood lymphocytes and CD8+ T lymphocytes (as CTLs) in rabbits infected with 6 Lagovirus europaeus GI.1a viruses.

Material and Methods
Sixty rabbits of Polish hybrid breed comprising both sexes and weighing 3.2–4.2 kg were the experimental group, and an identical group was the control. Each of the six GI.1a Lagovirus europaeus viruses was inoculated into ten experimental rabbits. Control rabbits received glycerol as a placebo. Flow cytometric analysis was performed on blood from the study and control group animals for peripheral blood lymphocyte apoptosis and CTL percentage determination.

Results
The activation of apoptosis in peripheral blood lymphocytes was recorded from 4 h post inoculation (p.i.) up to 36 h p.i. The percentage of CTLs in the total blood pool decreased from 8 to 36 h p.i. A negative correlation between apoptosis of lymphocytes and the number of CTLs was proven.

Conclusion
This may be the first evidence of virus-induced CTL apoptosis in Lagovirus europaeus GI.1a infection.