bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predictive value for mortality of left ventricular wall thickness in dilated cardiomyopathy
Authors: Li Jing , Feng Yue‐yue , Hu Chun‐ai , Zhao Yan , Hou Ju‐pan , Xu Hui , Dou Li‐na , Lou Ming , Han Bing 
Published: September 2023

AbstractAimsThe purpose of this study was to explore the predictive value of wall thickness measured by cardiac magnetic resonance (CMR) for all‐cause mortality in dilated cardiomyopathy (DCM) patients.Methods and resultsDCM patients who underwent CMR and completed the regular follow‐up were included in this study. The left ventricular end‐diastolic diameter (LVDd), left ventricular end‐diastolic volume (LVEDV), left ventricular posterior wall thickness (PWT), interventricular septum thickness (IVST), left ventricular ejection fraction, and left ventricular mass (LVM) were measured by CMR. The presence and extent of late gadolinium enhancement (LGE) were also assessed. The relative posterior wall thickness (RWTPW) and relative interventricular septum wall thickness (RWTIVS) were defined by the following equations: RWTPW = (2 × PWT)/LVDd, and RWTIVS = (2 × IVST)/LVDd. All patients received regular telephone and outpatient follow‐up. The primary endpoint was all‐cause mortality. A total of 161 patients were enrolled in this study, including 126 (78.3%) males. The mean age was 52.3 ± 13.6 years. During the median follow‐up of 47 months (interquartile range 32–57 months), 41 (24.8%) patients died. Compared with the non‐death group, LVDd (75.2 ± 11.9 vs. 70.5 ± 8.8 mm; P = 0.025) was greater in the death group, while PWT [5.2 mm (3.7–6.8) vs. 6.9 mm (5.3–8.6); P < 0.001], IVST [8.2 mm (6.5–9.5) vs. 9.3 mm (7.4–10.5); P = 0.005], RWTPW [0.15 (0.11–0.19) vs. 0.20 (0.15–0.25); P < 0.001], RWTIVS [0.22 (0.17–0.26) vs. 0.26 (0.22–0.31); P < 0.001], and LVM/LVEDV ratio (0.5 ± 0.2 vs. 0.7 ± 0.2 g/mL; P < 0.001) were lower. The presence of LGE [LGE(+)] was more frequent in the death group (75.6% vs. 58.3%; P = 0.048). However, the LGE extent was not significantly different between the two groups [4 (1–7) vs. 2 (0–6); P = 0.096]. Multivariate Cox regression analysis showed that PWT [hazard ratio (HR) 0.086, 95% confidence interval (CI) 0.665–0.976; P < 0.05] and RWTPW (HR 0.001, 95% CI 0.000–0.502; P < 0.05) were independent predictors of all‐cause death. In contrast, IVST, RWTIVS, and the presence of LGE were not clearly associated with death.ConclusionsPWT measured by CMR is an independent predictor of all‐cause mortality in DCM patients. However, there was no significant correlation between septum wall thickness and mortality.
Crown‐Ether‐Ring Size Dependent Crystal Structures, Phase Transition and Dielectric Properties of [M(crown)]BF4⋅xH2O (M+=Na+, K+; crown=15‐crown‐5, 18‐crown‐6; x=0 or 1)
Authors: Yuan Guo‐Jun , Luan Ye‐Ting , Miao Ji‐Bin , Wang Cai‐Feng , Chen Li , Chen Chao , Chen Hong , Li Li , Ren Xiao‐Ming 
Published: September 2023

AbstractCrown ethers demonstrate significant conformational flexibility and rotational symmetry, rendering them invaluable in the realms of supramolecular chemistry and crystal engineering. These unique natures facilitate the construction of supramolecular crystals of crown ethers, characterized by disorder‐order phase transitions, imparts unique properties that hold promise for diverse applications across multiple fields. In this study, four supramolecular compounds, namely [Na(15‐crown‐5)]BF4 (1), [Na(18‐crown‐6)]BF4⋅H2O (2), [K(15‐crown‐5)]BF4 (3) and [K(18‐crown‐6)]BF4⋅H2O (4) were synthesized and characterized by microanalysis, thermogravimetric analysis, differential scanning calorimetry and powder X‐ray diffraction techniques. Herein, 15‐crown‐5 and 18‐crown‐6 correspond to 1,4,7,10,13‐pentaoxacyclopentadecane and 1,4,7,10,13,16‐hexaoxacyclooctadecane, respectively. It was observed that the crystal structure, phase transition, and dielectric properties of these supramolecular compounds are significantly influenced by the size of the crown‐ether rings. The research extensively discussed the correlation between the coordination mode of metal ions of K+ or Na+ with crown ethers, the compatibility between metal ions and crown‐ether rings in terms of size, and the effects of crown‐ether disorder on dielectric permittivity during phase transitions. Our discoveries hold significant implications for the design and development of crown‐ether supramolecular functional materials.
Efficient Synthesis and Microwave‐Assisted Sonogashira Reactions of Triflate‐Substituted Porphyrin
Authors: Arcudi Francesca , Sartorel Andrea , Fortunato Anna , Marangoni Tomas , Demitri Nicola , Maggini Michele , Đorđević Luka 
Published: September 2023

AbstractPorphyrins that bear halogens at the meso‐aryl positions are useful building blocks for the preparation of light‐harvesting arrays and materials through cross‐coupling procedures. Despite the wide use of such intermediates, their scale‐up and purification are usually hampered by tedious chromatographic separations because of the statistical nature of the synthetic protocol and the similar polarity of the different products. Here, we propose the use of porphyrins bearing a triflatophenyl group as alternative starting materials for palladium cross‐coupling reactions. In particular, purification of the zinc 5,10,15‐triaryl‐20‐(4‐triflatophenyl)porphyrin (ZnP‐OTf) model compound by column chromatography proved to be much easier compared to porphyrin analogues that carry halogen substituents. This is the result of the increased polarity of compounds functionalized by highly polar triflate groups if compared to those substituted by halogens. To show the value of the triflatophenylporphyrin model compound in cross‐coupling reactions, we developed a microwave‐assisted Sonogashira protocol that quantitatively converts the ZnP‐OTf to the corresponding alkynylphenylporphyrin, in relatively short reaction times. Finally, we showed that the proposed ZnP‐OTf building block can be conveniently converted into an alkynyl‐linked molecular wire to bridge the zinc porphyrin donor with the [60]fullerene acceptor in a molecular dyad. The prepared dyad showed efficient photoinduced charge separation from singlet ZnP excited state to [60]fullerene in a polar solvent.
Mitochondrial dynamics modulate the allergic inflammation in a murine model of allergic rhinitis
Authors: Chen Xu‐qing , Zhou Long‐yun , Ma Hua‐an , Wu Ji‐yong , Liu Shu‐fen , Wu Yong‐jun , Yan Dao‐nan 
Published: September 2023

AbstractObjectiveAllergic rhinitis (AR) is a common allergic disorder, afflicting thousands of human beings. Aberrant mitochondrial dynamics are important pathological elements for various immune cell dysfunctions and allergic diseases. However, the connection between mitochondrial dynamics and AR remains poorly understood. This study aimed to determine whether mitochondrial dynamics influence the inflammatory response in AR.MethodsIn the present study, we established a murine model of AR by sensitization with ovalbumin (OVA). Then, we investigated the mitochondrial morphology in mice with AR by transmission electron microscopy and confocal fluorescence microscopy, and evaluated the role of Mdivi‐1 (an inhibitor of mitochondrial fission) on allergic symptoms, inflammatory responses, allergic‐related signals, and reactive oxygen species formation.ResultsThere was a notable enhancement in mitochondrial fragmentation in the nasal mucosa of mice following OVA stimulation, whereas Mdivi‐1 prevented aberrant mitochondrial morphology. Indeed, Mdivi‐1 alleviated the rubbing and sneezing responses in OVA‐sensitized mice. Compared with vehicle‐treated ones, mice treated with Mdivi‐1 exhibited a reduction in interleukin (IL)‐4, IL‐5, and specific IgE levels in both serum and nasal lavage fluid, and shown an amelioration in inflammatory response of nasal mucosa. Meanwhile, Mdivi‐1 treatment was associated with a suppression in JAK2 and STAT6 activation and reactive oxygen species generation, which act as important signaling for allergic response.ConclusionOur findings reveal mitochondrial dynamics modulate the allergic responses in AR. Mitochondrial dynamics may represent a promising target for the treatment of AR.
Activating transcription factor 3: A potential therapeutic target for inflammatory pulmonary diseases
Authors: Li Dandan , Jing Juanjuan , Dong Xue , Zhang Chenyang , Wang Jia , Wan Xianyao 
Published: September 2023

AbstractBackgroundActivating transcription factor 3 (ATF3) is a nuclear protein that is widely expressed in a variety of cells. It is a stress‐inducible transcription gene and a member of the activating transcription factor/cAMP responsive element‐binding protein (ATF/CREB) family.MethodsThe comprehensive literature review was conducted by searching PubMed and Google Scholar. Search terms used were “ATF3”, “ATF3 and (ALI or ARDS)”, “ATF3 and COPD”, “ATF3 and PF”, and “ATF3 and Posttranslational modifications”.ResultsRecent studies have shown that ATF3 plays a critical role in many inflammatory pulmonary diseases, including acute lung injury (ALI)/acute respiratory distress syndrome (ARDS), chronic obstructive pulmonary disease (COPD), and pulmonary fibrosis (PF). ATF3 participates in many signaling pathways and complex pathophysiological processes, such as inflammation, immunity, endoplasmic reticulum stress, and cell proliferation. However, the role of ATF3 in current studies is controversial, and there are reports showing that ATF3 plays different roles in different pulmonary diseases.ConclusionsIn this review, we first summarized the structure, function, and mechanism of ATF3 in various inflammatory pulmonary diseases. The impact of ATF3 on disease pathogenesis and the clinical implications was particularly focused on, with an overall aim to identify new targets for treating inflammatory pulmonary diseases.
Research and scholarly methods: Community‐engaged research
Authors: Moczygemba Leticia R. , Singh Reshmi L. , Baffoe James O. 
Published: September 2023

AbstractCommunity‐engaged research (CER) is a collaborative approach used by health services researchers to integrate the voice of community stakeholders in research design to increase the relevance and impact of research in advancing health outcomes. CER is guided by principles such as leveraging strengths and resources of a community, ensuring research is mutually beneficial for all partners, facilitating co‐learning among all partners, disseminating findings to all partners, and committing long term to a community. The level of community engagement can range on a continuum from outreach, consultations, and community‐academic partnerships to community‐based participatory research depending on the type and extent of community stakeholder involvement. Given pharmacists' accessibility to the public and role as the medication expert across the health care continuum, pharmacist researchers can use CER to authentically engage communities to better understand medication‐related needs and design community‐informed interventions to optimize medication outcomes. The purpose of this paper is to provide a practical overview of CER for pharmacist researchers by: (1) introducing the CER continuum and describing how CER principles can be used before, during, and after a study, (2) describing practical considerations for conducting CER, and (3) discussing two examples of CER in improving medication‐related outcomes in health services research.
New Human Leukocyte Antigen (HLA) Antibody Formation and Creatinine Elevation With Abaloparatide in Kidney Transplant Recipient
Authors: Swanson Christine M. , Krohn Kelly , Wiseman Alexander , Rothman Micol S. 
Published: September 2023

ABSTRACTA 39‐year‐old female with a history of kidney transplant presented to the endocrinology clinic for osteoporosis evaluation after sustaining an ankle fracture from a fall. Her kidney transplant regimen (mycophenolate mofetil 360 mg twice a day, tacrolimus 0.5 mg every morning and 0.5–1 mg every evening, prednisone 5 mg/day) and baseline creatinine (1.0–1.2 mg/dL) had been stable for several years. After an appropriate secondary workup, she was started on abaloparatide 80 μg subcutaneous daily injections for osteoporosis. She had a good initial biochemical response to therapy. However, 5 months after abaloparatide initiation she was found to have a new elevation in serum creatinine (1.17 to 1.69 mg/dL) despite stable serum tacrolimus trough levels, and two new human leukocyte antigen (HLA) antibodies (anti‐HLA antibodies detected to Cw7 and DP28). Abaloparatide was stopped due to concern for immunogenicity. There was no evidence of rejection on kidney biopsy and she was restabilized on her transplant regimen with a new baseline creatinine of 1.3–1.6 mg/dL. The patient was subsequently started on teriparatide 20 μg daily subcutaneous injections for 2 years with good biochemical response, significant improvement in bone mineral density, and stable transplant regimen without additional signs of immunogenicity or rejection. This is the first case report to raise concern about immunogenicity with abaloparatide in solid organ transplant recipients. © 2023 The Authors. JBMR Plus published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research.
The impact of patients' social backgrounds assessment on nursing care: Qualitative research
Authors: Mizumoto Junki , Son Daisuke , Izumiya Masashi , Horita Shoko , Eto Masato 
Published: September 2023

AbstractBackgroundAlthough nurses are expected to address the social determinants of health (SDH) in clinical settings, the perspectives of front‐line nurses on the integration of SDH into their clinical practice remain unclear. Understanding the dynamism of this integration and its outcomes can yield crucial insights into effective nursing care. This study aims to elucidate the integration and adoption of tool‐based SDH assessment nursing programs and their impacts on daily nursing care.MethodsWe conducted qualitative research at a small community‐based hospital in Japan, where a tool‐based program characterized by social background interviews and documentation was implemented. Nurses at the hospital were recruited via purposive and snowball sampling. After hypothesis generation, semi‐constructed in‐depth online interviews were conducted. Each interview lasted between 30 and 50 min. The data were analyzed via thematic analysis using the framework approach.ResultsA total of 16 nurses participated. Participants' incorporation of the novel SDH assessment program was bolstered by prior learning and their recognition of its practical value. Institutional support and collaborative teamwork further facilitated the adoption of this innovation. Enhanced knowledge about the social contexts of their patients contributed to increased respect, empathy, and self‐affirmation among participants, consequently enhancing the quality of nursing care.ConclusionThrough team‐based learning, reflection, and support, nurses can integrate a tool‐based SDH assessment program into their daily nursing practice. This program has the potential to empower nurses to deliver more holistic care and redefine their professional identity. Further research is warranted to assess patient‐reported outcomes.
Enhancement of developmental defects in the boron‐deficient maize mutanttassel‐less1by reduced auxin levels
Authors: Matthes Michaela S. , Best Norman B. , Robil Janlo M. , McSteen Paula 
Published: September 2023

AbstractBackgroundPlant responses to deficiencies of the micronutrient boron are diverse and go beyond the well‐characterized function of boron in cell wall crosslinking. To explain these phenotypic discrepancies, hypotheses about interactions of boron with various phytohormones have been proposed, particularly auxin. While these hypotheses are intensely tested in the root meristem of the model species,Arabidopsis thaliana, studies in crop species and the shoot are limited.AimsTo address potential boron–auxin interactions during the vegetative and reproductive development of the crop maize (Zea mays), we utilized the boron‐deficienttassel‐less1(tls1) mutant and the auxin‐deficientvanishing tassel2(vt2) mutant. We investigated interactions of boron and auxin on the levels of auxin biosynthesis and auxin transport in leaves and shoot meristems.Methods and ResultsBy using genetic interaction analysis, hormone quantification, and confocal microscopy, we show that boron‐deficient leaf phenotypes intls1are enhanced in double mutants withvt2in both greenhouse and field conditions. However, auxin levels are not altered in developing leaves intls1. Rather, the localization ofZmPIN1a:YFP, a marker for auxin transport, is altered in young tassel meristems and is absent from organ initiation sites during vegetative development.ConclusionsOur data suggest a link between polar auxin transport and phenotypic consequences in boron‐deficient conditions and further show that boron deficiency‐induced developmental defects are sensitive to low auxin levels. Our study, therefore, offers new insight into nutrient–hormone interactions to regulate crop development.
Study on the effect and mechanism of chicken breast on the gel properties of silver carp (Hypophthalmichtys molitrix) surimi
Authors: Jiang Qixing , Wang Lishi , Gao Pei , Yu Peipei , Yang Fang , Yu Dawei , Chen Han , Xia Wenshui 
Published: September 2023

AbstractBACKGROUNDAdding appropriate exogenous substances is an effective means to improve the quality of freshwater fish surimi. The present study investigated the effects of chicken breast on the gel properties of mixed minced meat products.RESULTSWith the increase in the proportion of chicken breast, the breaking force of mixed gels gradually increased. When the addition ratio was 30:70, the gel strength of mixed gels had the highest strength of 759.00 g cm−1 and also the highest water holding capacity of 87.36%. Compared with surimi gels (0:100), the hardness, adhesiveness and chewiness of mixed gels were significantly improved. The increase in the proportion of chicken breast increased the thermal stability of the mixed sol and improved the rheological properties of the mixed sol. When the proportion was 40:60, the area of immobile water (A22) in the mixed gel increased significantly, and the highest A22 was 3463.24. The hydrophobic interactions and disulfide bonds in the mixed gel were significantly increased as a result of the addition of chicken breast. The results of microstructure, electrophoresis and Raman spectroscopy indicated that the addition of chicken breast promoted the cross‐linking of the proteins in mixed gels, which facilitated the transformation of the protein secondary structure from α‐helical to β‐folded structure, thus forming a more uniform and orderly network structure.CONCLUSIONThese results suggest that improving the gel properties of silver carp surimi by use of chicken breast has practical implications for the development of new blended products for surimi processing. © 2023 Society of Chemical Industry.
Versatile and High‐Performance LiTaO3:Tb3+, Gd3+ Perovskite for Multimode Anti‐counterfeiting, Flexible X‐Ray Imaging, Continuous Stress Sensing, and Non‐Real‐Time Recording
Authors: Lyu Tianshuai , Dorenbos Pieter , Wei Zhanhua 
Published: September 2023

AbstractMultimode luminescence relates to how charge carriers are transported and recombined in response to various physical excitations. It shows promising applications in many fields like advanced anti‐counterfeiting, information storage and encryption. Enabling a stable single compound with multimode luminescence is a unique technology but still remains a challenge. Herein, a versatile and high‐performance energy storage LiTaO3:0.01Tb3+,xGd3+ perovskite is discovered by utilizing the interplay of electron‐trapping defect levels and hole‐trapping Tb3+. It combines an excellent charge carrier storage capacity (≈7 and 12 times higher than state‐of‐the‐art BaFBr(I):Eu2+ and Al2O3:C), >1200 h storage duration, >40 h afterglow, efficient optically stimulated luminescence, persistent mechanoluminescence, and force‐induced charge carrier storage features. Particularly, it well responds to various stimuli channels, i.e., wide‐range X‐rays to 850 nm infrared photons, thermal activation, mechanical force grinding, or compression. To elucidate this multimode luminescence, charge carrier trapping and release processes in LiTaO3:0.01Tb3+,xGd3+ with various physical stimulations will be unraveled by combining the vacuum‐referred binding diagram construction, spectroscopy, thermoluminescence, and mechanoluminescence techniques. The versatile and high‐performance LiTaO3:0.01Tb3+,xGd3+ enables promising proof‐of‐concept multimode luminescence applications in advanced anti‐counterfeiting, flexible X‐ray imaging, continuous compression force sensing, and non‐real‐time recording.
High‐Impact PLA in Compatibilized PLA/PCL Blends: Optimization of Blend Composition and Type and Content of Compatibilizer
Authors: Fernández‐Tena Ainhoa , Otaegi Itziar , Irusta Lourdes , Sebastián Victor , Guerrica‐Echevarria Gonzalo , Müller Alejandro Jesus , Aranburu Nora 
Published: September 2023

AbstractIn this work, the effectiveness of seven commercial compatibilizers is tested in polylactide (PLA)/poly(ε‐caprolactone) (PCL) blends with different compositions to obtain a high‐impact PLA. None of the compatibilizers is effective for 90/10 and 80/20 PLA/PCL compositions, as no improvement of the impact strength is observed. For the 70/30 composition, compatibilizers having glycidyl methacrylate (GMA) and acrylate groups in their structure are proved the most effective, as the morphological change towards co‐continuity induced by them leads to significant impact strength improvements (of ≈345% and 90% with respect to the neat PLA and the noncompatibilized PLA/PCL 70/30 blend, respectively). The 70/30 PLA/PCL composition, as it shows the best balance of properties, and the best compatibilizer (ElvaloyPTW) are chosen to carry out the optimization of the compatibilizer content. It is found that adding 6 phr to the blend results in highly toughened and ductile blends while maintaining a high modulus and yield strength values. Larger compatibilizer contents lead to even higher impact strength values, but the low‐strain mechanical properties are notably reduced. Thus, in this work, a simple and easily scalable method to produce high‐impact PLA is shown, as it implies the compounding of three commercially available components without involving any toxic solvents.