bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cyclosporine A‐induced gingival overgrowth in renal transplant patients accompanied by epithelial‐to‐mesenchymal transition
Authors: Chen Min Zhi , Dai Xiao Feng , Sun Yang , Yu You Cheng , Yang Fei 
Published: March 2023

AbstractObjectiveTo investigate the association between the prevalence of cyclosporin A‐induced gingival overgrowth and the expression of the epithelial‐to‐mesenchymal transition factors in the gingival tissues of renal transplant patients.BackgroundGingival overgrowth (GO) is a frequent complication in organ transplant patients treated with the immunosuppressant cyclosporin A (CsA). The epithelial‐to‐mesenchymal transition (EMT) is considered a factor contributing to CsA‐induced GO. However, current knowledge on this topic is sparse.MethodsSixty‐three renal transplant patients were divided into two groups according to the occurrence of GO: those with gingival overgrowth (GO+ group) and those without gingival overgrowth (GO− group). Data on age, sex, and use of immunosuppressant and calcium channel blocker medications, serum creatinine values, peak concentrations of blood CsA, and gingival hyperplasia scores were recorded to identify clinically pathogenic factors. Gingival tissues from five patients with CsA‐induced GO and five healthy subjects were selected for histomorphological observation with hematoxylin–eosin staining, Masson staining, and immunohistochemical staining. The mRNA expression of EMT factors was detected with reverse transcription–quantitative PCR.ResultsThe use of CsA significantly increased the prevalence of GO in renal transplant patients. The expression of α‐SMA, SMAD4, and TGM2 was upregulated and that of E‐cadherin was downregulated in the gingival tissues of patients with CsA‐induced GO compared with those of the corresponding controls.ConclusionTreatment with CsA is closely related to the occurrence of GO in renal transplant patients and EMT plays an important role in CsA‐induced gingival tissue hyperplasia.
Cognitive behavioural therapy to treat stress and insomnia: A randomized wait list‐controlled trial of two online courses
Authors: Hürlimann Philipp , Bodenmann Guy , Riemann Dieter , Weitkamp Katharina 
Published: March 2023

SummaryThis randomized, wait list‐controlled trial aimed to evaluate the efficacy of the cognitive behavioural therapy‐based online e‐learning course stressfit for better stress management and the cognitive behavioural therapy for insomnia‐based online course SweetDreams for coping with insomniac problems. The course modules offer state of the art psychoeducation and cognitive behavioural strategies concerning different aspects of stress, sleep and insomnia. They provide practice‐oriented exercises for self‐reflection, as well as a variety of evidence‐based methods and measures to increase self‐efficacy when dealing with stress or insomnia. Study participants were randomly assigned to the three test conditions stressfit, SweetDreams or a wait list. Participants filled in questionnaires on a wide range of scales relevant to stress and insomnia at three points in time (before, 4 weeks after, and 3 months after the treatment). Of the 588 participants in total, data from 347 participants (59%) were finally included in the data analyses. Data analyses showed that both courses yielded significant positive effects compared with the wait list condition 4 weeks and to some degree 3 months after completion in relation to insomnia symptoms, physical and psychological wellbeing, life satisfaction and general health (General Health Questionnaire), as well as on satisfaction with and effectiveness of coping with stress and sleep disorders. In conclusion, SweetDreams and stressfit proved to be feasible and effective online cognitive behavioural therapy (for insomnia) tools to reduce insomnia and stress symptoms on a broad variety of scales at the 4‐weeks measurement point as well as at the 3‐months follow‐up.
Pragmatic competence, autistic language use and the basic properties of human language
Authors: Mao Tiaoyuan 
Published: March 2023

AbstractThe unique linguistic profile of autistic people urges linguists to address the divergences in human language, its acquisition and use among major linguistic perspectives. Fitting with the dual roles of language (thought and communication), this paper adopts an internal pragmatic competence (IPC) and a (similar) pragmatic competence for external communication (PCEC) to elucidate how autistic linguistic profile discloses the divergences between nativism and constructionism on language use and acquisition (ultimately language proper). IPC justifies why autistic people resort not to mind‐reading but to self‐sufficient mental interactions among organism‐internal submodules or nearly intact grammatical subsystems when abstractly processing linguistic and communicative needs, contra constructionists' assumption of sole intersubjective language use. PCEC, required for facilitating the authentic intersubjective language use, explains how the dysfunction of modular interactions and their interactions with outside contexts leads to autistics' sociopragmatic impairment and the double empathy gap. In this way, the divergences, along with the possible reconciliation between the two perspectives, can be expounded.
Bile acid increase during bulevirtide treatment of hepatitis D is not associated with a decline in HDV RNA
Authors: Deterding Katja , Xu Chengjian , Port Kerstin , Dietz‐Fricke Christopher , Xun Jiang , Maasoumy Benjamin , Cornberg Markus , Wedemeyer Heiner 
Published: March 2023

AbstractBulevirtide (BLV) is an entry inhibitor blocking entry of HBsAg into hepatocytes by interfering with the bile acid transporter Na+‐taurocholate co‐transporting polypeptide. We here investigated if bile acid levels before or during BLV treatment would correlate with HDV RNA declines. We studied 20 patients with compensated HDV infection receiving a daily dose of 2 mg bulevirtide subcutaneously qd for at least 24 weeks. ALT levels improved in all patients including 13/20 patients showing normal ALT values at treatment Week 24. An HDV RNA drop of at least 50% was evident in 20/20 patients at Week 24 including 10 patients showing a ≥ 2 log HDV RNA decline. Elevated bile acid levels were detected already before treatment in 10 patients and further increased during BLV administration with different kinetics. Baseline bile acids were associated with higher transient elastography values (p = .0029) and evidence of portal hypertension (p = .0004). Bile acid levels before treatment were associated with HDV RNA declines throughout therapy, but not at Week 24 (rho = −0.577; p = .0078; rho = −0.635, p = .0026; rho = −0.577, p = .0077; rho = −0.519, p = .0191; rho = −0.564, p = .0119 and rho = −0.393, p = .087 at treatment Weeks 2, 8, 12, 16, 20 and 24, respectively). However, bile acid increases during treatment were not associated with HDV RNA or ALT declines at any of the time points. BLV‐induced increases in bile salts do not correlate with HDV RNA declines suggesting that the inhibitory effects of BLV on NTCP differ between blocking bile acid transport and hindering HBsAg entry. If baseline bile salt levels could be useful to predict virological response remains to be confirmed.
Socioeconomic Status and Reading Development: Moving from “Deficit” to “Adaptation” in Neurobiological Models of Experience‐Dependent Learning
Authors: Taylor Ellie K. , Abdurokhmonova Gavkhar , Romeo Rachel R. 
Published: March 2023

AbstractChildhood socioeconomic status (SES) is one of the strongest predictors of student reading outcomes, and these disparities have persisted for decades. Relatedly, two underlying skills that are required for successful reading—oral language and executive function (EF)—are also the two neurocognitive domains most affected by SES. In this review, we summarize current knowledge on how SES influences the neurobiology of language, EF, and their intersection, including the proximal factors that drive these relationships. We then consider the burgeoning evidence that SES systematically moderates certain brain–behavior relationships for language and EF, underscoring the importance of considering context in investigations of the neurobiological underpinnings of reading development. Finally, we discuss how disparities in reading may be conceptualized as neurobiological adaptations to adversity rather than deficit models. We conclude that by harnessing children's stress‐adapted relative strengths to support reading development, we may address opportunity gaps both ethically and efficaciously.
Using a whole genome co‐expression network to inform the functional characterisation of predicted genomic elements from Mycobacterium tuberculosis transcriptomic data
Authors: Stiens Jennifer , Tan Yen Yi , Joyce Rosanna , Arnvig Kristine B. , Kendall Sharon L. , Nobeli Irene 
Published: March 2023

AbstractA whole genome co‐expression network was created using Mycobacterium tuberculosis transcriptomic data from publicly available RNA‐sequencing experiments covering a wide variety of experimental conditions. The network includes expressed regions with no formal annotation, including putative short RNAs and untranslated regions of expressed transcripts, along with the protein‐coding genes. These unannotated expressed transcripts were among the best‐connected members of the module sub‐networks, making up more than half of the ‘hub’ elements in modules that include protein‐coding genes known to be part of regulatory systems involved in stress response and host adaptation. This data set provides a valuable resource for investigating the role of non‐coding RNA, and conserved hypothetical proteins, in transcriptomic remodelling. Based on their connections to genes with known functional groupings and correlations with replicated host conditions, predicted expressed transcripts can be screened as suitable candidates for further experimental validation.
MSP1 encodes an essential RNA‐binding pentatricopeptide repeat factor required for nad1 maturation and complex I biogenesis in Arabidopsis mitochondria
Authors: Best Corinne , Mizrahi Ron , Edris Rana , Tang Hui , Zer Hagit , Colas des Francs‐Small Catherine , Finkel Omri M. , Zhu Hongliang , Small Ian D. , Ostersetzer‐Biran Oren 
Published: March 2023

Summary
Mitochondrial biogenesis relies on nuclearly encoded factors, which regulate the expression of the organellar‐encoded genes. Pentatricopeptide repeat (PPR) proteins constitute a major gene family in angiosperms that are pivotal in many aspects of mitochondrial (mt)RNA metabolism (e.g. trimming, splicing, or stability). Here, we report the analysis of MITOCHONDRIA STABILITY/PROCESSING PPR FACTOR1 (MSP1, At4g20090), a canonical PPR protein that is necessary for mitochondrial functions and embryo development.
Loss‐of‐function allele of MSP1 leads to seed abortion. Here, we employed an embryo‐rescue method for the molecular characterization of msp1 mutants.
Our analyses reveal that msp1 embryogenesis fails to proceed beyond the heart/torpedo stage as a consequence of a nad1 pre‐RNA processing defect, resulting in the loss of respiratory complex I activity. Functional complementation confirmed that msp1 phenotypes result from a disruption of the MSP1 gene.
In Arabidopsis, the maturation of nad1 involves the processing of three RNA fragments, nad1.1, nad1.2, and nad1.3. Based on biochemical analyses and mtRNA profiles of wild‐type and msp1 plants, we concluded that MSP1 facilitates the generation of the 3′ terminus of nad1.1 transcript, a prerequisite for nad1 exons a–b splicing. Our data substantiate the importance of mtRNA metabolism for the biogenesis of the respiratory system during early plant life.
The transcription factor MYB43 antagonizes with ICE1 to regulate freezing tolerance in Arabidopsis
Authors: Zheng Pengpeng , Cao Lei , Zhang Cheng , Fang Xue , Wang Lihuan , Miao Min , Tang Xiaofeng , Liu Yongsheng , Cao Shuqing 
Published: March 2023

Summary
Previous discovering meticulously illustrates the post‐translational modifications and protein stability regulation of ICE1 and their role in cold stress. However, the studies on the interaction of ICE1 with other transcription factors, and their function in modulation cold stress tolerance, as well as in the transition between cold stress and growth are largely insufficient.
In this work, we found that maltose binding protein (MBP) 43 directly binds to the promoters of CBF genes to repress their expression, thereby negatively regulating freezing tolerance.
Biochemical and genetic analyses showed that MYB43 interacts and antagonizes with ICE1 to regulate the expression of CBF genes and plant's freezing stress tolerance. PLEIOTROPIC REGULATORY LOCUS 1 (PRL1) accumulates under cold stress and promotes MYB43 protein degradation; however, when cold stress disappears, PRL1 restores normal protein levels, causing MYB43 protein to re‐accumulate to normal levels. Furthermore, PRL1 positively regulates freezing tolerance by promoting degradation of MYB43 to attenuate its repression of CBF genes and antagonism with ICE1.
Thus, our study reveals that MYB43 inhibits CBF genes expression under normal growth condition, while PRL1 promotes MYB43 protein degradation to attenuate its repression of CBF genes and antagonism with ICE1, and thereby to the precise modulation of plant cold stress responses.
Growth failure among children of adolescent mothers at ages 0–5 and 6–12 years in India
Authors: Nandi Arindam , Zahra Fatima , Austrian Karen , Haberland Nicole , Ngô Thoại D. 
Published: March 2023

AbstractAdolescent motherhood has been linked with poor health outcomes at birth for children, including high neonatal mortality, low birthweight, and small‐for‐gestational‐age rates. However, longer‐term growth outcomes in the children of adolescent mothers in low‐resource settings remain inadequately studied. We used longitudinal data from the India Human Development Surveys, 2004–2005 and 2011–2012 (n = 12,182) and employed regression and propensity score matching analysis to compare the following growth indicators of children born to adolescent mothers (ages 19 years or below) with those born to older mothers. Growth indicators included height and weight during ages 0–5 years and 6–12 years and change in height and weight between the two periods. In regression‐based estimates, children born to adolescent mothers were 0.01 m shorter and weighed 0.2 kg less than children of older mothers at ages 0–5 years. At ages 6–12 years, those born to adolescent mothers were 0.02 m shorter and weighed 0.97 kg less. The height difference between the two groups increased by 0.01 m and the weight difference grew by 0.77 kg over time. Height and weight difference between the two groups worsened among boys over time, while for girls, only the weight gap worsened. The results were similar when using propensity score matching methods. Public policies for reducing child marriage, combined with targeted health, nutrition, and well‐being programs for adolescent mothers, are essential for both preventing adolescent childbearing and reducing its impact on growth failure among children in India.
Analysis of the synchronisation of energy consumption: Evidence from G7 countries
Authors: Kassouri Yacouba , Bilgili Faik , Kuşkaya Sevda , Alola Andrew Adewale 
Published: March 2023

AbstractGiven differences in the efficiency of oil use of local and foreign technologies across countries, characterising the degree of synchronisation of oil consumption is of great concern and consequence for economic, political, and, not least, climate change reasons. Building on the business cycle theory, we characterise the degree of synchronisation of oil consumption with world consumption among the G7 countries over the period 1890–2017. We provide three crucial points based on the wavelet and phase difference analyses. Firstly, we find that the synchronisation of oil consumption in the largest oil consumers with world consumption was continuous only during periods prior to the great depression of the 1930s, suggesting the lack of a stable synchronisation pattern in oil consumption. In addition, we show that during that period, oil consumption in each G7 country started approaching world consumption. Secondly, the phase relation structure infers a clear pattern of positive correlations (being in phase) between each country's oil consumption and world consumption, mainly during the short run. This strong evidence of interdependency yields beneficial information for monitoring world oil demand by improving the efficiency of oil in the underlying countries. Thirdly, we report that oil consumption patterns in France, the United Kingdom and the United States are the closely synchronised oil consumers with a procyclical pattern after 2010, supporting convergence features in their oil consumption series.
A comparative study of governance changes on the perceptions of accountability in Fire and Rescue Services in England
Authors: Lakoma Katarzyna 
Published: March 2023

AbstractPublic organizations are increasingly held accountable by multiple institutions and standards. This study explores how key actors perceive accountability changes in Fire and Rescue Services in England. However, few studies have examined perceptions of accountability where long‐established governance arrangements are changing. The UK's Policing and Crime Act 2017 provided for a new model of governance in the form of a single directly elected commissioner to replace the traditional indirectly elected fire authority. This study uses a comparative multiple case study design to understand the impact of the governance arrangements on individuals' perceptions of accountability within each service. It adds to the wider understanding of the influences of institutional structures on individuals' perceptions and actions, and it demonstrates that accountability perceptions change depending on the way public services are governed.
Relationship between decrement time and recovery time in pediatric total intravenous anesthesia with propofol and remifentanil
Authors: Bagshaw Oliver 
Published: March 2023

AbstractBackgroundPropofol target‐controlled infusion is now used in many countries for the administration of total intravenous anesthesia (TIVA) and uses population pharmacokinetic data incorporated into the target‐controlled infusion pump to administer a dose which will achieve a target concentration selected by the practitioner. Modern target‐controlled infusion pumps can include an estimate of how long it will take for the plasma propofol concentration to fall to a value programmed into the pump, once the propofol infusion is stopped. This is known as decrement time. Many users consider decrement time to be equivalent to recovery time for the patient, despite the several assumptions that makes.AimTo determine if the decrement time estimated by the target‐controlled infusion pumps at the end of anesthesia could be reliably used to predict recovery time for individual patients.MethodsTarget‐controlled infusion pumps at Birmingham Children's Hospital are programmed with a propofol decrement concentration of 1.5 μg.mL−1. Patients for a variety of surgical procedures were anesthetised with propofol–remifentanil TIVA. Eye opening was used as a surrogate of recovery time. Data were analyzed using median absolute deviation, Mann–Whitney U test, and linear regression to see if there was any correlation with decrement time and recovery time, total dose of propofol administered, duration of anesthesia and patient age.ResultsA total of 55 patients were audited. Median age was 7.2 years (range 0.9–15.9), and median weight was 26 kg (range 8.5–77). Median decrement time was 11.8 min (IQR 8.3–21), while median recovery time was 15 min (IQR 9–20). Recovery time was the same as decrement time in 2% of patients, less than in 40% of patients and more in 58% of patients. Two thirds of patients opened eyes at an estimated plasma propofol concentration between 1.2 and 1.8 μg.mL−1. The median absolute deviation for the difference between decrement time and recovery time was 5.7 min, from a median of 1 min. Analysis demonstrated there was no statistical correlation between decrement time to 1.5 μg.mL−1 and recovery time, age, total propofol dose administered, or duration of anesthesia, for individual patients.ConclusionThere was variation between decrement time to 1.5 μg.mL−1 and recovery time of over 5 min in nearly half of patients. Decrement time to 1.5 μg.mL−1 must be used with caution when trying to predict recovery time for individual patients following TIVA.
Reacting to the Rural Burden: Understanding Opposition to Utility‐Scale Solar Development in Upstate New York☆
Authors: Nilson Roberta S. , Stedman Richard C. 
Published: March 2023

AbstractRural landscapes are under increasing development pressure from utility‐scale solar (USS) energy facilities while public attitudes toward these facilities remain poorly documented and understood. This study explores whether opposition to USS in upstate New York is shaped at least in part by perceived rural burden—the idea that rural people and places are unfairly expected to provide new renewable energy in response to urban demand. We explore the idea of rural burden with measures of distributive injustice, procedural injustice, periphery identity, and place attachment. We use a survey (N = 421) of residents of western and northern New York, regions with substantial new and pending USS development. We find that 42 percent of residents oppose USS installations in or near their local communities, 14 percent neither support nor oppose, and 44 percent support. Perceived distributive and procedural injustice, along with place attachment have the strongest effect on opposition, while socio‐demographic attributes, political ideology, and climate change beliefs were insignificant. These findings suggest that opposition to large scale renewable energy development exemplifies a rural environmental justice concern justified for many by the perceived legacy of exploitation in natural resource development.
Dueling incumbent primaries in U.S. House elections
Authors: Ashton H. Benjamin , Crespin Michael H. , McKee Seth C. 
Published: March 2023

AbstractObjectiveReapportionment and the attendant process of redistricting cause instances where incumbents are faced with the decision to retire or run against a congressional colleague. We investigate two major questions surrounding the previously understudied population of dueling incumbent primaries: First, under what conditions is a dueling incumbent primary likely to manifest? Second, how are dueling incumbent primaries different from the typical primary featuring a single incumbent?MethodsWe address these questions using a novel dataset aggregating descriptive congressional district information on these contests from 1962 to 2016, and separately for 2022.ResultsOur findings show these contests primarily emerge via electoral retrenchment, meaning a state loses representation in reapportionment. Dueling incumbent primaries also arise from the strategic calculations of partisan line drawers.ConclusionsNot only do dueling incumbent primaries comprise a disproportionate share of incumbent defeats, but compared to single incumbent contests, primary duels feature very high redrawn constituencies, voters new to these incumbents, and this reality contributes to the high‐risk/reward nature of these rare but electorally consequential contests.