bluuebunny/crossref_metadata_2025_split huggingface dataset:
Responsive Spiral Photonic Structures for Visible Vapor Sensing, Pattern Transformation and Encryption
Authors: Qian Jing , Kolagatla Srikanth , Pacalovas Aleksejus , Zhang Xia , Florea Larisa , Bradley A. Louise , Delaney Colm 
Published: January 2023

AbstractTwo photon polymerisation using direct laser writing is a burgeoning field of research, with recent focus being placed on bringing added value to microstructures, by incorporating soft, responsive polymers. Moving to the micron‐scale can have a profound impact on such stimuli‐responsive materials, whose speed of actuation can be increased many‐fold compared to their mm‐scale counterparts. Here, the fabrication of submicron 2D photonic structures, based on a vapor‐responsive photoresist with a refractive index <1.55, in the visible wavelength range. The fabricated concentric spiral arrays are evaluated for their feasibility as vapor sensors by testing spectral and structural color reproducibility and reversibility under water, ethanol, isopropanol, and acetone vapors. This approach allows for the realization of predictable uniform color displays that can be modulated upon stimuli response. The transmitted colour in the dry and hydrated states can be accurately modelled. This knowledge is used to design and demonstrate structures for cloaking and image transformation. Such capability can be used for encryption and anti‐counterfeiting applications.
A Novel Tri‐Functional Liposome Re‐Educates “Cold Tumor” and Abrogates Tumor Growth by Synergizing Autophagy Inhibition and PD‐L1 Blockade
Authors: Zhou Fei , Li Xiaojiaoyang , Xue Xiaoyong , Li Shuo , Fan Guifang , Cai Yajie , Chang Zihao , Qu Jiaorong , Liu Runping 
Published: January 2023

AbstractImmunotherapy has been regarded as a breakthrough in cancer treatment and achieved great success. However, the poor response rate is still a formidable challenge of current immunotherapies, especially in solid tumors without sufficient infiltration of immune cells, also known as “cold tumor.” SAR405 is a highly specific VPS34 inhibitor and has been suggested as a potential approach converting “cold tumor” into “hot tumor” by inhibiting autophagy. In this study, a tri‐functional doxorubicin (DOX) plus SAR405 liposome system is established and further modified with a novel anti‐PD‐L1 peptide JY4 for targeted delivery (DOX‐SAR‐JY4LIPO). The data here demonstrate that in a lung cancer xenograft mouse model, by facilitating the tumoral enrichment of both SAR405 and DOX, DOX‐SAR‐JY4LIPO effectively increases the infiltration of cytotoxic lymphocytes in the tumor by synergizing DOX‐induced immunogenic cell death (ICD) and SAR405‐mediated upregulation of chemokines including CCL5 and CXCL10. As results, DOX‐SAR‐JY4LIPO significantly inhibits tumor growth, metastasis, and resurrection by re‐educating immunosuppressive tumor microenvironment. In conclusion, this study not only proves the concept of inhibiting autophagy for better immune infiltration in the tumor but also presents a novel tri‐functional liposomal system that overcomes the deficiencies of current therapies and holds great promise in cancer immunotherapy.
Persistent Luminescence Induced by Upconversion: An Alternative Approach for Rechargeable Bio‐Emitters
Authors: Giordano Luidgi , Cai Guanyu , Seguin Johanne , Liu Jianhua , Richard Cyrille , Rodrigues Lucas Carvalho Veloso , Viana Bruno 
Published: January 2023

AbstractThe charging of persistent luminescence using an infrared laser as a power source and an upconversion process is a recently proposed trend in the field of persistent luminescence that allows expansion of the potential applications for these materials. In bioimaging at nanoscale, it allows for increased rechargeability capacity, as the excitation wavelength is fully inside the biological window. In this work, a novel approach is proposed to this phenomenon using energy transfer on associated materials. For this purpose, β‐NaGd0.8Yb0.17Er0.03F4 nanoparticles, known for their efficient upconversion, and Zn1.33Ga1.335Sn0.33Cr0.005O4 nanoparticles, known for their persistent luminescence properties, have been synthesized and associated through a dry impregnation method. The obtained hybrid material is found to present persistent luminescence at 700 nm after charging with a 980 nm laser. A mechanism is proposed to explain this energy transfer process and the capabilities of the hybrid material as rechargeable persistent nanoprobe for in vivo applications are shown.
Aerobic Cu(I)‐Catalyzed Site‐Selective 1,3‐Difunctionalization of Indazole through Cascade C−N and C−O Bond Formation
Authors: Kanta Das Krishna , Kumar Ghosh Asim , Mallick Tamanna , Ara Begum Naznin , Hajra Alakananda 
Published: January 2023

AbstractA Cu(I)‐catalyzed 1,3 oxo alkylation of indazole has been developed for constructing N‐1‐alkylated indazolone derivatives. This cascade reaction involves the formation of C−N and C−O bonds through the sequential functionalization of N1 and C3 positions of indazole in 41–89% yields. The photo‐physical studies of the synthesized compounds showed efficient quantum yields with high Stoke shift values. The preliminary experimental results suggest an aerobic manifold of the present protocol through single electron transfer.magnified image
Oxidative Annulation of Aldehydes, 5‐Aminopyrazoles, and Nitriles: Synthesis and Applications of Pyrazolo[3,4‐d]Pyrimidines
Authors: Yao Guangkai , Zhu Chuanle , Qin Tianyi , Wang Mengfan , Sun Zhixiu , Tang Ri‐Yuan , Zhao Chen , Jiang Huanfeng , Xu Hanhong 
Published: January 2023

AbstractThe oxidative [3+2+1] annulation reaction of aldehydes, 5‐aminopyrazoles, and nitriles is achieved under the oxidation of I2/O2, affording various valuable pyrazolo[3,4‐d]pyrimidines in 27%–91% yields. The salient feature of this reaction is transition‐metal free, operationally simple, broad substrate scope, good functional group tolerance, and gram‐scalable. Remarkably, the corresponding products exhibited intriguing photophysical properties such as Aggregation‐Induced Emission (AIE) and intramolecular charge transfer (ICT) and showed good potential to specifically light up lipid droplets (LDs) in living cells with bright fluorescence, low cytotoxicity, and good photostability.magnified image
Community participation and subjective wellbeing among the immigrant population in Northern Italy: An analysis of mediators
Authors: Martinez‐Damia Sara , Paloma Virginia , Luesia Juan F. , Marta Elena , Marzana Daniela 
Published: January 2023

AbstractCommunity participation can be a potential strategy to increase the degree of the subjective wellbeing of immigrants within receiving societies. This study aims to analyze the relationship between immigrants' community participation and their subjective wellbeing, testing the two dimensions of sense of mattering (feeling valued and adding value) and psychological sense of community as potential mediators of this relationship. A total of 308 first‐generation immigrants living in Northern Italy filled out a questionnaire (45.1% were members of a migrant community‐based organization). We found that immigrants who are members of a migrant organization show a higher level of subjective wellbeing, sense of mattering, and psychological sense of community than those who are not members. We also found that the sense of adding value and the psychological sense of community serve as mediators of the relationship between community participation and subjective wellbeing. The findings suggest that active participation is positively related to immigrants' feeling useful and capable of contributing to society and their feeling of belonging, which, in turn, are positively related to their subjective wellbeing. Practical implications are presented, focusing on the need for generative social policies to move beyond the welfarist perspective in which immigrants only “receive” to embrace an active perspective in which immigrants can also “give.”
Role of Enlarged Perivascular Space in the Temporal Lobe in Cerebral Amyloidosis
Authors: Na Han Kyu , Kim Han‐Kyeol , Lee Hye Sun , Park Mina , Lee Jae Hoon , Ryu Young Hoon , Cho Hanna , Lyoo Chul Hyoung 
Published: January 2023

ObjectiveAlthough growing evidence suggests that perivascular space (PVS) serves as a clearance route for amyloid and tau, the association between enlarged PVS (EPVS) and Alzheimer disease is highly inconsistent across studies. As the conventional visual rating systems for EPVS were insufficient to predict amyloid/tau/neurodegeneration (A/T/N) status, we developed a new rating scale for EPVS located in the temporal lobe (T‐EPVS).MethodsEPVS located in the basal ganglia (BG‐EPVS), centrum semiovale (CS‐EPVS), and T‐EPVS was visually rated in 272 individuals (healthy controls, n = 96; mild cognitive impairment, n = 106; dementia, n = 70) who underwent structural magnetic resonance imaging (MRI) and dual positron emission tomography scans (18F‐flortaucipir and 18F‐florbetaben). T‐EPVS and BG‐EPVS were defined as high degree when the counts in any hemisphere were >10, and the CS‐EPVS cutoff was >20. Logistic regression models were constructed to investigate whether the regional EPVS burden was predictive of A/T/N status. The derived models were externally validated in a temporal validation cohort (n = 195) that underwent MRI studies using a different scanner.ResultsCompared with those with low‐degree T‐EPVS (23/136, 16.9%), individuals with high‐degree T‐EPVS/CS‐EPVS but low‐degree BG‐EPVS were more likely to exhibit amyloid positivity (46/56, 82.1%). High‐degree T‐EPVS burden (odds ratio [OR] = 7.251, 95% confidence interval [CI] = 3.296–15.952) and low‐degree BG‐EPVS (OR = 0.241, 95% CI = 0.109–0.530) were predictive of amyloid positivity. Although high‐degree T‐EPVS was associated with tau positivity, the association was no longer significant after adjusting for amyloid and neurodegeneration status.InterpretationInvestigating the burden and topographic distribution of EPVS including T‐EPVS may be useful for predicting amyloid status, indicating that impaired perivascular drainage may contribute to cerebral amyloidosis. ANN NEUROL 2023;93:965–978
Supramolecular Shish Kebabs: Higher Order Dimeric Structures from Ring‐in‐Rings Complexes with Conformational Adaptivity
Authors: Wang Zhenwen , Mei Lei , Guo Chenxing , Huang Song , Shi Wei‐Qun , Li Xiaowei , Feng Wen , Li Xiaopeng , Yang Cheng , Yuan Lihua 
Published: January 2023

AbstractUse of abiotic chemical systems for understanding higher order superstructures is challenging. Here we report a ring‐in‐ring(s) system comprising a hydrogen‐bonded macrocycle and cyclobis(paraquat‐o‐phenylene) tetracation (o‐Box) or cyclobis(paraquat‐p‐phenylene) tetracation (CBPQT4+, p‐Box) that assembles to construct discrete higher order structures with adaptive conformation. As indicated by mass spectrometry, computational modeling, NMR spectroscopy, and single‐crystal X‐ray diffraction analysis, this ring‐in‐ring(s) system features the box‐directed aggregation of multiple macrocycles, leading to generation of several stable species such as H4G (1 a/o‐Box) and H5G (1 a/o‐Box). Remarkably, a dimeric shish‐kebab‐like ring‐in‐rings superstructure H7G2 (1 a/o‐Box) or H8G2 (1 a/p‐Box) is formed from the coaxial stacking of two ring‐in‐rings units. The formation of such unique dimeric superstructures is attributed to the large π‐surface of this 2D planar macrocycle and the conformational variation of both host and guest.
Near‐Quantitative Preparation of Short Single‐Stranded DNA Circles
Authors: Paluzzi Victoria E. , Zhang Cuizheng , Mao Chengde 
Published: January 2023

AbstractSmall, single‐stranded DNA (ssDNA) circles have many applications, such as templating rolling circle amplification (RCA), capturing microRNAs, and scaffolding DNA nanostructures. However, it is challenging to prepare such ssDNA circles, particularly when the DNA size becomes very small (e.g. a 20 nucleotide (nt) long ssDNA circle). Often, such short ssDNA dominantly form concatemers (either linear or circular) due to intermolecular ligation, instead of forming monomeric ssDNA circles by intramolecular ligation. Herein, a simple method to overcome this problem by designing the complementary linker molecules is reported. It is demonstrated that ssDNA, as short as 16 nts, can be enzymatically ligated (by the commonly used T4 DNA ligase) into monomeric ssDNA circles at high concentration (100 μM) with high yield (97 %). This method does not require any special sequence, thus, it is expected to be generally applicable. The experimental protocol is identical to regular DNA ligation, thus, is expected to be user friendly for general chemists and biologists.
Preparation and property analysis of kaolin/melamine cyanurate/aluminum diethylphosphinate/recycled PET composites
Authors: Li Xiang , Fang Songgang 
Published: January 2023

AbstractIn the plastic industry, recycling waste plastic was an effective way to save energy and reduce emissions, therefore, using recycled PET (R‐PET) to produce flame retardant PET could not only improved the recycling value of discarded PET, but also conducive to achieving carbon neutrality. The effects of melamine cyanurate (MCA), aluminum diethylphosphinate (ADP) and kaolin (Kaol) on flame retardant, combustion behavior, thermal degradation behaviors and mechanical properties of R‐PET composites were investigated by methods of limited oxygen index (LOI) measurement, vertical burning test, cone calorimeter test, thermogravimetry analysis (TG), SEM analysis and mechanical properties test. The results showed that MCA, ADP and Kaol could improve the flame retardant of R‐PET, and ADP had the best effect on improved the flame retardant of R‐PET. MCA and ADP had synergistic flame retardant in R‐PET, but MCA had a negative effect on the mechanical properties and thermal decomposition temperature of ADP/R‐PET composite. Kaol could not only improve the flame retardant and thermal decomposition temperature of MCA/ADP/R‐PET composites, but also improved their tensile and flexural strength. The flame retardant of 4‐Kaol/5‐MCA/15‐ADP/R‐PET composite reached UL94 1.0 mm V0 with LOI was 36.5%, and the tensile and flexural strength were increased by 26.1% and 16.7% compared with 5‐MCA/15‐ADP/R‐PET, respectively.
Synthesis of cross‐linked diazaborine‐based polymeric microparticles with antiquorum sensing, anti‐swarming, antimicrobial, and antibiofilm properties
Authors: Tamfu Alfred Ngenge , Kocak Gökhan , Ceylan Ozgur , Valentine Funda , Bütün Vural , Çiçek Hüseyin 
Published: January 2023

AbstractTransmission of infectious diseases and resistance by microorganisms is a global health threat. Antimicrobial polymers are increasingly being developed as biocides with greater applications than traditional antibiotics. In this study, 3‐(potassiumsulfonyl)propyl methacrylate (SPMA) monomer, ethylene glycol dimethacrylate cross‐linker and ammonium persulfate initiator were reacted to yield poly[3‐(potassiumsulfonyl)propyl methacrylate] microgels (PSPMA). Surface modification of PSPMA with thionyl chloride yielded poly[3‐(chlorosulfonyl)propyl methacrylate microparticle] (PSPMA‐Cl) which was reacted with hydrazinehydrate to obtain poly[3‐(hydrazinylsulfonyl)propyl methacrylate] microparticles (PSPMA‐NH2). Finally, 2‐formyl benzeneboronic acid was added to give the final product poly[3‐((1‐hydroxybenzo(d)(1,2,3)diazaborinin‐2(1H)‐yl)sulfonyl)propyl methacrylate] (PSPMA‐DAZ) microparticles. The modified microparticles were characterized using attenuated total reflectance‐Fourier transform infrared spectroscopy, thermogravimetric analysis, scanning electron microscopy and energy‐dispersive x‐ray analyses. The polymeric microparticles showed good antibiofilm activity against Staphylococcus aureus ATCC 25923, Escherichia coli ATCC 25922, Candida albicans ATCC 10239 and Candida tropicalis ATCC 13803 while low to moderate biofilm inhibitions were observed against Listeria monocytogenes ATCC 7644, Enterococcus faecalis ATCC 29212, Pseudomonas aeruginosa ATCC 27853 and Salmonella typhi ATCC 14028. Surface group modification from PSPMA, PSPMA‐Cl, PSPMA‐NH2 to PSPMA‐DAZ increased violacein inhibition, quorum‐sensing inhibition and antimicrobial activity but reduced swarming. These polymer microparticles can be used to reduce spread of microbial infections and resistance.
Hair cell morphological patterns and polarity organization in the sea lamprey vestibular cristae
Authors: Fritzsch Bernd , Kersigo Jennifer , Rejent Kassidy , Gherman Wesley , Frank Patrick W. , Giovannucci David R. , Maklad Adel 
Published: January 2023

AbstractThe inner ear of the sea lamprey was examined by scanning electron microscopy, antibody labeling with tubulin, Myo7a, Spectrin, and Phalloidin stain to elucidate the canal cristae organization and the morphology and polarity of the hair cells. We characterized the hair cell stereocilia bundles and their morphological polarity with respect to the kinocilia. We identified three types of hair cells. In Type 1 hair cells, the kinocilia were slightly longer than the tallest stereocilia. This type was located along the medial bank of the crista and their polarity, based on kinocilia location, was uniformly pointed ampullipetally. Type 2 hair cells that had kinocilia that were much longer than the stereocilia, were most abundant in the central region of the crista. This type of hair cell displayed variable polarity. Type 3 hair cells had extremely long kinocilia (~40–50 μm long) and with extremely short stereocilia. They were mostly located in the lateral zone crista and displayed ampullipetal polarity. Myo7a and tubulin antibodies revealed that hair cells and vestibular afferents are distributed across the canal cristae in the lamprey, covering the area of cruciate eminence; a feature that is absent in more derived vertebrates. Spectrin shows hair cells of varying polarities in the central zone. In this zone, some cells followed the main polarity vector (lateral) like those in medial and lateral zones, whereas other cells displayed polarities that carried up to 40° from the main polarity vector.
Ethyl 2‐(2‐fluoroethoxy)ethyl carbonate as a new electrolyte additive for high‐voltage Li‐metal batteries
Authors: Jin Dahee , Park Changhee , Han Jiwon , Dzakpasu Cyril B. , Kim Eunsae , Oh Jimin , Kim Kwang Man , Lee Sunggi , Lee Yong Min 
Published: January 2023

AbstractThe combination of a high‐Ni LiNixMnyCo1−x−yO2 (NMC) cathode and Li metal anode is currently considered the most promising candidate for high‐energy‐density Li‐metal batteries. However, undesired parasitic reactions in LiPF6‐based carbonate electrolytes hinder their further application. Herein, we report a new fluorinated linear carbonate additive, ethyl 2‐(2‐fluoroethoxy)ethyl carbonate) (EFEEC), to a lithium bis(trifluoromethanesulfonyl) imide–lithium bis(oxalate)borate‐based dual‐salt electrolyte system which is compatible with high‐Ni NMC and Li metal electrodes. We showed that in our electrolyte with well‐controlled lowest unoccupied molecular orbital/highest unoccupied molecular orbital levels, robust and stable solid electrolyte interphases are formed on both the cathode and anode synergistically, which enables neat and dense lithium metal deposition as well as the structural stability of NMC622 operated under a 4.5 V cut‐off voltage. The use of the dual‐salt‐based electrolyte with the EFEEC additive improved cycle performance with high‐capacity retention (76.0% at 200 cycles) even when operated under high voltage.
High rate and ultralong cyclelife fiber‐shaped sodium dual‐ion battery based on bismuth anodes and polytriphenylamine cathodes
Authors: Li Yongpeng , Wang Bin 
Published: January 2023

AbstractFiber‐shaped sodium dual‐ion batteries (FSDIBs) have attracted considerable attention in wearable electronics because of their low cost and natural abundance and intrinsic flexibility, as well as high working voltage and energy density. Thus, exploration of an electrode material with good flexibility and more accommodative spaces for the reversible shuttle of large anions and Na+ cations is quite necessary but challenging. Herein, Bi nanoparticles anchored on a carbon nanotube fiber are homogeneously fabricated and used as anodes to assemble FSDIBs with carbon fiber‐coated polytriphenylamine cathodes. A series of in situ/ex situ characterizations are conducted to investigate the corresponding battery reaction mechanism of anodes, revealing a reversible reaction process of mixed insertion‐alloying behavior. Owing to excellent electrochemical properties and electrode match, the FSDIBs show ultralong cycle stability for 5000 cycles at 5 A g−1 and remarkable rate capability ranging from 2.5 to 20 A g−1. Moreover, the FSDIBs also show good flexibility under different bending deformations. This work paves the way for development of flexible energy storage devices for wearable devices.
A simple urine test by 3D‐plus‐3D immunoassay guides precise in vitro cancer diagnosis
Authors: Kim Hye Hyun , Moon Ok Jeong , Seol Yong Hwan , Lee Jeewon 
Published: January 2023

AbstractAlthough a variety of urinary cancer markers are available for in vitro diagnosis, inherent problems of urine environment—containing various inorganic/organic ions/molecules that vary in concentration over a 20‐fold range or more and significantly attenuate antibody avidity for markers—render conventional immunoassays unsuitable, remaining unresolved and a major challenge. Here we developed a 3D‐plus‐3D (3p3) immunoassay method, based on a single‐step urinary marker detection by 3D‐antibody probes, which are free of steric hindrance and capable of omnidirectional capture of markers in a 3D solution. The 3p3 immunoassay showed an excellent performance in the diagnosis of prostate cancer (PCa) through detecting PCa‐specific urinary engrailed‐2 protein, demonstrating 100% sensitivity and 100% specificity with the urine specimens of PCa‐related and other related disease patients and healthy individuals. This innovative approach holds a great potential in opening up a novel clinical route for precise in vitro cancer diagnosis and also pushing urine immunoassay closer to more widespread adoption.
Cell recognitive bioadhesive‐based osteogenic barrier coating with localized delivery of bone morphogenetic protein‐2 for accelerated guided bone regeneration
Authors: Jo Yun Kee , Choi Bong‐Hyuk , Zhou Cong , Jun Sang Ho , Cha Hyung Joon 
Published: January 2023

AbstractTitanium mesh (Ti‐mesh) for guided bone regeneration (GBR) approaches has been extensively considered to offer space maintenance in reconstructing the alveolar ridge within bone defects due to its superb mechanical properties and biocompatibility. However, soft tissue invasion across the pores of the Ti‐mesh and intrinsically limited bioactivity of the titanium substrates often hinder satisfactory clinical outcomes in GBR treatments. Here, a cell recognitive osteogenic barrier coating was proposed using a bioengineered mussel adhesive protein (MAP) fused with Alg–Gly–Asp (RGD) peptide to achieve highly accelerated bone regeneration. The fusion bioadhesive MAP‐RGD exhibited outstanding performance as a bioactive physical barrier that enabled effective cell occlusion and a prolonged, localized delivery of bone morphogenetic protein‐2 (BMP‐2). The MAP‐RGD@BMP‐2 coating promoted in vitro cellular behaviors and osteogenic commitments of mesenchymal stem cells (MSCs) via the synergistic crosstalk effects of the RGD peptide and BMP‐2 in a surface‐bound manner. The facile gluing of MAP‐RGD@BMP‐2 onto the Ti‐mesh led to a distinguishable acceleration of the in vivo formation of new bone in terms of quantity and maturity in a rat calvarial defect. Hence, our protein‐based cell recognitive osteogenic barrier coating can be an excellent therapeutic platform to improve the clinical predictability of GBR treatment.