bluuebunny/crossref_metadata_2025_split huggingface dataset:
Choroidal Measurements in Decision Making for Retinopathy of Prematurity: A Decision Tree Analysis
Authors: Bahar Mohammadreza Mehrabi , Salari Farhad , Dastjanifarahani Afsar , Ghassemi Fariba , III C. Armitage Harper , Bazvand Fatemeh 
Published: May 2023

Abstract
Objective: To compare the choroidal thickness and vascular profile of premature infants with ROP (retinopathy of prematurity) using a handheld SD-OCT device.
Design: A prospective cross-sectional case-control study
Subject: All ROP patients examined under sedation or general anesthesia in Farabi Eye Hospital or Mahdie Hospital from 2020 to 2022.
Methods: We performed horizontal SD-OCT scans through the fovea in 164 eyes of 82 premature infants. Premature infants included 2 groups (infants with ROP requiring treatment [as treatment group] vs. infant without ROP or with ROP not- requiring treatment [as no-treatment group]) Choroidal thicknesses (CT) were measured at 5 points, including the fovea, 250 µm, and 500µm mm nasal and temporal to the fovea. The choroidal vascularity index (CVI) and choroidal stromal index (CSI) were also calculated. The classification and regression tree (CRT) algorithm was used to predict the need for treatment based on all OCT characteristics.
Main outcome: Treatment-require ROP patients.
Results: Mean CT was higher in 500 micrometers nasal to the fovea compared to temporal CT (275.8 ± 64.8 and 257.1 ± 57.07, P value<0.03). No statistically significant difference was found regarding CVI, corrected CVI, and temporal and nasal CT in the treatment group versus the no-treatment group. The foveal CT was significantly lower in ROP patients with the plus disease compared to not-plus ROP (P value=0.03. ANOVA, Bonferroni posthoc test). CT was not significantly different between plus and pre-plus patients (P-value=0.9, ANOVA, Bonferroni posthoc test). No significant relationship was found between the stage of ROP and choroidal thickness (P value>0.05, GEE). The decision tree analysis showed that in infants with ROP, the most important predictor for the need for treatment is CVI.
Conclusion:
This study delineated the possible effectiveness of choroidal measurements as an additive to decision-making for ROP. We also demonstrated that choroidal involution is associated with the presence of pre-plus/plus, not with the stage of ROP. We demonstrated that choroidal measurements are very sensitive but not specific tools for assessing the need for treatment in ROP patients.
Exploring the Mechanism of Inula japonica Thunb. against Non-small Cell Lung Cancer using a computer-aided drug design approach
Authors: Qian Huiqin , Wang Bailing 
Published: May 2023

Abstract
Context:Inula japonica Thunb. (IJT) is widespread to treat non-small cell lung cancer (NSCLC) in China with antiasthma, antitussive, and expectorant effect. However, due to the complexity of compounds and targets, the pharmacological mechanisms of IJT needs further research. The study explores the mechanisms of IJT against NSCLC through network pharmacology, molecular docking and molecular dynamics (MD) simulation. The results showed that quercetin and luteolin were selected as major compounds, and 23 putative targets of IJT against NSCLC were picked out as major hubs. The major targets just modulated the NSCLC pathway, which included Ras, ERBB, MAPK, PI3K-Akt, calcium, and p53 signaling sub-pathways. Moreover, they involved in apoptosis, cell cycle, tumor progression, proliferation, and many other significant biological processes. The molecular docking simulation showed that all the major compounds with NSCLC pathway-relevant targets of IJT had effective binding. Further, MD simulations revealed that the lutolin-AKT1 and quercetin-AKT1 complexes possessed a steady state and bound extremely stably during molecular docking.
Methods: In the present study, the ingredients and targets prediction, compound-target (C-T), and protein-protein interaction (PPI) networks analysis, molecular docking, and MD simulations were applied to mine the anti-NSCLC mechanisms of IJT.
Distal oblique bundle influence on distal radioulnar joint stability – a biomechanical study
Authors: Hohenberger Gloria , Pirrung Felix , Hammer Niels , Niestrawska Justyna Anna 
Published: May 2023

Abstract
Chronic instability of the distal radioulnar joint (DRUJ) presents a highly disabling condition. Several surgical techniques have been reported for its treatment. These involve reconstruction of the distal oblique bundle (DOB) of the interosseous membrane (IOM) of the forearm. The aim of this study was to examine whether surgical reconstruction of the DOB is necessary to restore DRUJ stability following trauma with DOB disruption and to compare two restoration techniques utilizing a tendon or suture-button graft. Stability in supination and pronation was assessed by means of maximum torque and force in twenty forearms. Test cycles were performed with the DOB/IOM in an intact condition, with the DOB or distal IOM transected, and following surgical reconstruction of the DOB with either tendon graft or suture-button system. In pronation, the relative change in maximum axial force was significantly lower in samples with a transected DOB in comparison to samples without a preexisting DOB. No statistically significant differences were observed between forearms including DOB reconstruction and specimens in the intact and transected state. Neither were there statistically significant differences concerning the two surgical techniques. From a biomechanical perspective, surgical DOB reconstruction is hence not indicated in cases of isolated DOB rupture.
Prediction of Nipple Involvement in Breast Cancer after Neoadjuvant Chemotherapy: Should We Rely on Breast MRI to Preserve the Nipple?
Authors: Ugurlu M.Umit , Bugdayci Onur , Akmercan Ahmet , Kaya Handan , Telli Tugba Akin , Akoglu Haldun , Gulluoglu Bahadir M 
Published: May 2023

Abstract
Background: Indications for nipple sparing mastectomy (NSM) is extending to post-neoadjuvant chemotherapy (NAC) setting. Eligibility for NSM with an optimum tumor nipple distance (TND) after NAC is unclear. We examined predictive factors for nipple tumor involvement in patients undergoing total mastectomy following NAC.
Methods: Clinical and pathological data from prospectively collected medical records of women with invasive breast carcinoma, who were undergone NAC and total mastectomy with sentinel lymph node biopsy and/or axillary lymph node dissection. PreNAC and postNAC magnetic resonance imaging (MRI) were examined and a cut-off TND value for predicting the negative nipple tumor status was determined.
Results: Among 180 women, the final mastectomy specimen analysis revealed that 12 (7%) had nipple involvement as invasive carcinoma. Patients with nipple involvement had more postNAC multifocal/multicentric tumors (p:0.03), larger tumors on preNAC and postNAC images (p: 0.002 and p:<0.001) , shorter median TNDs on preNAC and postNAC images (7mm-IQR:1.5-14, p: 0.005 and 8.5-IQR:3-15.5, p: <0.001, respectively), more nipple retraction on preNAC and postNAC images (p: 0.007 and p:0.006) and more nipple areola complex skin thickening on preNAC and postNAC images (p: <0.001 and p: 0.01). The best likelihood ratios (LR) belonged to the post-NAC positivity of the 20 mm TND, with a +LR of 3.40, and -LR of 0.11 for nipple involvement. Pre-NAC positivity of the 20 mm TND also had a similar -LR of 0.14.
Conclusion: A TND ≥ 2 cm on preNAC and postNAC MRI was shown to be highly predictive of negative nipple tumor involvement.
Cross-Domain Multi-disease Ocular Disease Recognition via Data Enhancement
Authors: Wang Qiong , Guo Zhilin , Yao Jun , Yan Nan 
Published: May 2023

Abstract
Ophthalmic diseases afflict many people, and can even lead to irreversible blindness. Therefore, the search for effective early diagnosis methods has attracted the attention of many researchers and clinicians. At present, although there are some ways for the early screening of ophthalmic diseases, the early screening of fundus images based on deep learning is generally favored by the medical community due to its non-contact characteristic, non-invasive characteristic and high recognition accuracy. However, the generalization performance of a common model and cross-domain identification is usually weak due to different collection equipment, race, and patient conditions. Although the existing fundus image recognition technology has achieved some results, the effect is still in the cross-domain problem and is not satisfactory. In this paper, a cross-domain fundus image recognition framework based on deep neural networks with data enhancement is proposed. First, the ResNeXt101 model is chosen as the basic framework. Second, some data enhancement methods and focal loss are used to improve recognition performance. Finally, the results of experiment show that the final score of the framework is improved by about 10% using ordinary data enhancement methods and focal loss. In summary, the method proposed in this paper can effectively solve the problem of poor generalization ability for cross-domain early fundus screening and can provide inspiration and ideas for future related works.
Early Postoperative Digestive Obstruction Syndrome:tomographic Predictive Factors for Surgical Intervention
Authors: Bedel Jean-Baptiste , Burel Julien , Floch Mathilde , Cour Adrien , Hermary Capucine , Dacher Jean-Nicolas , Savoye-Collet Céline 
Published: May 2023

Abstract
BACKGROUND
The early postoperative context is a complex situation and CT signs are poorly studied in the literature. The objective is to evaluate the usual tomographic signs of digestive obstruction in the early postoperative period (< 21 days) of abdominal-pelvic surgery and to search for predictive factors of surgical management.
METHODS
We searched for adult patients who presented with digestive obstruction diagnosed by a CT scan in the early postoperative period (<21 days) of abdominal-pelvic surgery in our center over a period of 21 months. Relevant epidemiological, clinical, biological and tomographic characteristics for this pathology were collected for each patient. The new surgical management was recorded in order to search for predictive factors for surgical management by univariate and multivariate analysis.
RESULTS
In this study, 109 patients were recruited (aged from 20 to 92 years with a median of 63 years). The type of obstruction observed was mainly a functional digestive obstruction and secondarily a mechanical digestive obstruction due to adhesions. Some signs were frequent (62% pneumoperitoneum and 26% mesenteric edema) and others rare or absent (4% wall enhancement defect, 0% spontaneous hyperdensity of the digestive wall). 33 patients (30%) underwent surgical management. Only the aspect of digestive obstruction due to adhesions (p = 0.003) and strangulated parietal hernia (p = 0.002) were identified as predictive factors of surgical management. Other mechanisms of digestive obstruction were not predictive of surgical management in multivariate analysis. Pneumoperitoneum (p = 0.801) and mesenteric edema (p = 0.229) did not demonstrate predictability of surgical management despite their high frequency. Wall enhancement defect was not predictive of surgical management (p = 1). More specific tomographic signs of the surgical context were not predictive of surgical management (e.g., intra-abdominal drain p = 0.668).
CONCLUSION
CT signs of digestive obstruction in the early postoperative period of abdominal-pelvic surgery seem to be superimposable on those in the general context, except for some signs such as pneumoperitoneum, which lose their predictive value for surgical management. Only the aspect of obstruction due to adhesions and strangulated parietal hernia were found as predictive signs of surgical management
The impact of different type 2 diabetes states stratified by baseline HbA1c on the periodontal outcomes of non-surgical periodontal treatment: a systematic review and network meta-analysis
Authors: Kang Shuai , Liu Zhang-ya , Yuan Huan-huan , Wang Shu-min , Pan Ge-ge , Wei Wei , Jiang Yi , Hou Yu 
Published: May 2023

Abstract

Background Type 2 diabetes mellitus (T2DM) has been considered by many studies to have a bidirectional relationship with periodontitis. This systematic review and network meta-analysis aimed to investigate the impact of different T2DM states stratified by baseline HbA1c on the clinical outcomes of non-surgical periodontal treatment (NSPT). Methods This study followed the Preferred Reporting Items for Meta-Analyses (PRISMA) guidelines and involved an electronic literature search (from inception to the 2nd of January 2023). We included at least two groups of patients: chronic periodontitis only (No-DM) or periodontitis and well-control/poor-control type 2 diabetes mellitus (WC/PC-T2DM). Clinical outcomes included probing depth (PD) reduction, bleeding on probing (BOP) reduction, and clinical attachment level(CAL)gain. Direct and indirect comparisons between groups were assessed by network meta-analysis, allowing us to establish a treatment ranking. Results Ten prospective cohort studies (11 data sets) were included for qualitative analysis and network meta-analysis. The data included in this study had high consistency; in addition, a funnel plot and Egger’s test showed that the articles had low publication bias. The network meta-analysis showed that the NSPT effect in the No-DM group was significantly better than the WC-T2DM group [Weighted mean difference (WMD) = 0.09, 95% confidence interval (CI) (0.01, 0.18)] and PC-T2DM group [WMD = 0.09, 95%CI (0.01, 0.18)] in terms of CAL gain and better than the PC-T2DM group [WMD = 0.15, 95%CI (0.02, 0.28)] in terms of PD reduction. According to the SUCRA value, the No-DM group had the highest probability of achieving the best NSPT outcome. Conclusions The findings of this systematic review revealed that the NSPT had the best therapeutic effect in patients without diabetes mellitus. Further high-quality studies are now required to validate these findings.
Combined use of tumor markers in gastric cancer: A novel method with promising prognostic accuracy and practicality
Authors: zhang ruopeng , chen xiaojiang , chen guoming , zhao zhoukai , wei yicheng , zhang feiyang , lin jun , nie runcong , chen yingbo 
Published: May 2023

AbstractBackground The effect of a single tumor marker on the prognosis of gastric cancer patients is not ideal. This study explored a novel prognostic assessment method for gastric cancer (GC) patients using a combination of three important tumor markers (CEA, CA72-4 and CA19-9). Method The data of 1966 GC patients who underwent curative gastrectomy at Sun Yat-Sen University Cancer Center (Guangzhou, China) were included. Hazard ratios (HR) for all factors for overall survival (OS) were analyzed by Cox regression. Nomogram and calibration curve was used to establish the survival prediction model. The prediction accuracy was evaluated with the concordance index (C-index). Results All patients were divided into four groups (C0-C3) according to the number of elevated tumor markers. The 5-year OS rates of the patients in preoperative groups C0-C3 were 83.8% (81.3%-86.4%), 72.8% (68.5%-77.4%), 58.9% (50.4%-68.9%), and 18.5% (4.0%-33.0%), respectively, and those in postoperative groups C0-C3 were 82.1% (79.4%-84.8%),76.1% (72.2%-80.3%) ,57.6% (48.4%-68.5%), and 16.8% (5.1%-28.5%), respectively, with significant differences between each C0-C3 subgroup both in pre- and post-cohort. Multivariate analysis showed that preoperative (HR: 6.001, 95%CI: 3.523–10.221) and postoperative (HR: 8.149, 95%CI: 4.962–13.528) elevated tumor markers were independent risk factors for GC patients. The C-index for the combined use of tumor markers was 0.65–0.66, which was higher than that for using a single tumor marker (0.53–0.56). Conclusion The combined use of tumor markers significantly improved the prognostic value compared to using a single tumor marker. The survival prediction model including the combined tumor markers was accurate and effective.
The Frequency of Intermediate Alleles in Patients With Cerebellar Phenotypes
Authors: Capacci Elena , Bagnoli Silvia , Giacomucci Giulia , Rapillo Costanza , Govoni^ Alessandra , Bessi Valentina , Polito° Cristina , Sorbi Sandro , Nacmias Benedetta , Ferrari Camilla 
Published: May 2023

Abstract
Cerebellar syndromes are clinically and etiologically heterogeneous and can be classified as hereditary, neurodegenerative non-hereditary and acquired. Few data are available on the frequency of each form in the clinical setting. Furthermore, growing interest is emerging regarding the genetic forms caused by triplets repeat expansions. Alleles with repeat expansion lower than the pathological threshold, termed intermediate alleles (IAs), have been found associated with diseases’ manifestations. In order to assess the relevance of IAs as cause of cerebellar syndrome, we enrolled 66 unrelated Italian ataxic patients and we described the distribution of the different etiology of their syndromes and the frequency of IAs. Each patient underwent a complete clinical, hematological, neurophysiological assessments, neuroimaging evaluations and genetic tests for autosomal dominant cerebellar ataxia (SCA) and fragile X associated tremor/ataxia syndrome (FXTAS). We identified the following diagnostic categories: 28% Sporadic Adult-Onset Ataxia, 18% cerebellar variant of Multiple System Atrophy, 9% acquired forms, 9% genetic forms with full-range expansion, 12% cases with intermediate-range expansion. The IAs were six in FXTAS-gene, two in SCA8-gene, and one in the SCA2-gene. The clinical phenotype of patients carrying the IAs resemble, in most of the cases, the one associated with the full-range expansion. Our study provides an exhaustive description of the causes of cerebellar ataxia, estimating for the first time the frequency of IAs in SCAs- and FXTAS- associated genes. The high percentage of cases with IAs supports further screening among patients with cerebellar syndromes.
"There could be something going wrong and I wouldn’t even know": A qualitative study of perceptions of people with cancer about CVD risk and its management.
Authors: Knowles Reegan , Kemp Emma , Miller Michelle , Koczwara Bogda 
Published: May 2023

Abstract
Purpose
Despite being at higher risk, many people with cancer do not receive adequate cardiovascular disease (CVD) risk assessment or management. The purpose of this research was to examine people with cancer’s perceptions, experiences and needs regarding CVD risk factor awareness, assessment and management.
Methods
We conducted 14 individual interviews to examine people with cancer’s perspectives regarding CVD care in cancer. Reflexive thematic analysis was utilized to collect and organize data into themes and to synthesise findings.
Results
Fourteen people (6 males) diagnosed with diverse cancer types participated. Majority participants were not, or only somewhat aware of CVD risk in cancer but all expressed it was an important issue. A diverse range of priorities and needs for CVD care were discussed, including some participants’ prioritization of dealing with cancer, and preferred amount, type and manner of information provision and support. Websites and brochures were identified as potential solutions for optimizing CVD care.
Conclusions
Codesign methodology should be used to engage patients in the development of flexible, tailored resources to increase awareness of CVD risk and strategies for its management.
Implications for cancer survivors:
Perceptions of people with cancer regarding CVD care can inform new interventions that reduce the impact of CVD in cancer.
The effect of air filtration on biomarkers of inflammation and oxidative stress: A systematic review and meta-analysis of randomized controlled trials
Authors: Ren Jingyi , Zhang Zhenao , Li Ruiqiang , Tian Hao , Guo Zihao , Xue Wei , Zhang Yadong , Chen Fengge , Deng Yandong , Ma Yuxia 
Published: May 2023

Abstract
BACKGROUND
Improvement of indoor air quality is beneficial for human health. However, previous studies have not reached consistent conclusions regarding the effects of indoor air filtration on inflammation and oxidative stress.
OBJECTIVE
This study aims to determine the relationship between indoor air filtration and inflammation and oxidative stress biomarkers.
METHODS
We conducted an electronic search that evaluated the association of indoor air filtration with biomarkers of inflammation and oxidative stress in five databases (PubMed, Cochrane Library, EMBASE, Web of Science, and Scopus) from the beginning to April 23, 2022. Outcomes included the following markers: interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), C-reactive protein (CRP), malondialdehyde (MDA), 8-hydroxy-2deoxyguanosine (8-OHdG), and 8-iso-prostaglandinF2α (8-isoPGF2α). We extracted data from the included studies according to the system evaluation and the preferred reporting item for meta-analysis (PRISMA) guidelines and used the Cochrane risk of bias tool to assess bias risk.
RESULTS
Our meta-analysis included 15 studies with 678 participants to assess the combined effect size. The meta-analysis demonstrated that indoor air filtration could have a marked reduction in IL-6 (SMD: -0.275, 95% CI: − 0.545 to − 0.005, p = 0.046) but had no significant effect on other markers of inflammation or oxidative stress. Subgroup analysis results demonstrated a significant reduction in 8-OHdG levels in the subgroup with < 1 day of duration (SMD: − 0.916, 95% CI: − 1.513 to − 0.320; p = 0.003) and using filtrete air filter (SMD: − 5.530, 95% CI: − 5.962 to − 5.099; p < 0.001).
CONCLUSION
Our meta-analysis results depicted that indoor air filtration can significantly reduce levels of inflammation and oxidative stress markers. Considering the adverse effects of air pollution on human health, our study provides powerful evidence for applying air filtration to heavy atmospheric pollution.
Design, synthesis and antitumor activity evaluation in vitro of
4,6,7-trisubstituted quinazoline derivatives containing acrylamide moiety
Authors: Si Xiaojie , Yu Fuqiang , Wang Hao , Chi Lingling , Dai Honglin , Gao Chao , Zhu Yingnan , Liu Hongmin , Zhang Qiurong 
Published: May 2023

Abstract
In order to search for new antitumor drugs with high efficiency, a series of novel quinazoline derivatives containing acrylamide group were designed, synthesized and evaluated for antiproliferative activity against four human cancer cell lines (PC-3, H1975, A549 and Eca-109) using MTT assay in vitro. Among them, compound N-(3-((6-((4-cyanobenzyl)oxy)-7-methoxyquinazolin-4-yl)amino)phenyl)acrylamide (14m) showed good anti-tumor proliferation activity against four tested cancer cell lines, with IC50 values of 1.09 ± 0.04µM to H1975 cell. The antitumor activity was significantly better than that of 5-FU. Further mechanism studies showed that compound 14m inhibit the proliferation and migration of H1975 cells, block its cell cycle at G2/M phase and induce its apoptosis in a concentration dependent and time-dependent manner.