bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of Knowledge and Awareness of Periodontal Health and its relation to General Health among Medical Doctors-A Cross-Sectional Questionnaire Survey
Authors: Gummaluri Shiva Shankar , R G Shiva Manjunath , Chaudhary Bharti , Bhattacharya Hirak S , Boyapati Ramanarayana , Mohammad Sheema Tasneem 
Published: January 2023

Background: Maintaining good oral health plays crucial in upholding one’s general health in a good shape. Present study has aimed to evaluate the knowledge of the above statement and awareness, and its relation to its general health among medical doctors.

Materials and Methods: The study encompasses of 400 medical doctors (Clinical and Non-Clinical) having > 26 years of age. A questionnaire proforma, having 18 questions was provided to the participants and answered data was gathered. Further, collected data was subjected to statistical analysis. Frequency distribution percentages were calculated and depicted.

Results: In case of periodontal awareness, significance difference was obtained between the non-clinical and clinical doctors regarding right brushing technique (p=0.048) favouring clinical doctors and dental visit for every 3 months favoured non-clinical doctors (p<0.001) while rest of the questions didn’t show any significant difference. Regarding periodontal knowledge, significant difference between clinical and non-clinical doctors were recorded in poor oral hygiene affecting the general health (p=0.0304) whereas rest of the parameters were non-significant.
Conclusion: Conducting periodic dental awareness programs among medical doctors would be beneficial for early detection of dental problems and treating them at appropriate time. So that local infections nidus would not become systemic problems.
The opposite effect of convulsant drugs on neuronal and endothelial nitric oxide synthase – A possible explanation for the dual proconvulsive/anticonvulsive action of nitric oxide
Authors: Vega Rasgado Lourdes A. , Ramón-Gallegos Eva , Rodríguez-Páez Lorena , Alcántara-Farfán Verónica 
Published: January 2023

Abstract
Nitric oxide (NO) participates in processes such as endothelium-dependent vasodilation and neurotransmission/neuromodulation. The role of NO in epilepsy is controversial, attributing it to anticonvulsant but also proconvulsant properties. Clarification of this dual effect of NO might lead to the development of new antiepileptic drugs. Previous results in our laboratory indicated that this contradictory role of NO in seizures could depend on the nitric oxide synthase (NOS) isoform involved, which could play opposite roles in epileptogenesis, one of them being proconvulsant but the other anticonvulsant. The effect of convulsant drugs on neuronal NO (nNO) and endothelial NO (eNO) levels was investigated. Considering the distribution of neuronal and endothelial NOS in neurons and astrocytes, resp., primary cultures of neurons and astrocytes were used as a study model. The effects of convulsant drugs pentylenetetrazole, thiosemicarbazide, 4-aminopyridine and bicuculline on NO levels were studied, using a spectrophotometric method. Their effects on NO levels in neurons and astrocytes depend on the concentration and time of treatment. These convulsant drugs caused an increase in nNO, but a decrease in eNO was proportional to the duration of treatment in both cases. Apparently, nNO possesses convulsant properties mediated by its effect on the glutamatergic and GABAergic systems, probably through GABAA receptors. Anticonvulsant properties of eNO may be the consequence of its effect on endothelial vasodilation and its capability to induce angiogenesis. Described effects last as seizures do. Considering the limitations of these kinds of studies and the unexplored influence of inducible NO, further investigations are required.
Sodium butyrate attenuate hyperglycemia-induced inflammatory response and renal injury in diabetic mice
Authors: Yan Man , Zhang Yan-Yan , Xi Yue , Ding Long-Kun , Sun Chang , Qu Li-Juan , Qian Xin , Xu Jing-Wen , Sun Wen , Wu Liang 
Published: January 2023

Abstract
The activation of the monocyte-macrophage system and the damage to the renal and pancreatic tissue are common complications in patients with diabetes induced by hyper-glycemia. This study aimed to evaluate the effect and mechanism of butyrate (NaB), a metabolite of intestinal flora, on inhibiting the inflammatory response of human monocyte-macrophages (THP-1 cells) induced by high glucose and the damage of pancreatic and renal tissue in diabetic mice. The results showed that high concentration glucose significantly up-regulated the expressions of IL-1β, TNF-α, and NLRP3 in THP-1 cells and mouse spleen, and that NaB could inhibit the overexpression of those genes. The abundance of Beclin-1, LC3B and reactive oxygen species (ROS) in THP-1 cells is increased due to the high glucose concentration, and NaB can inhibit the genes responsible for upregulating the expression. In diabetic mice, vacuolar degeneration of renal tubules was observed. Then we observed that some of the epithelial cells of the renal tubules were exfoliated and some formed tubules. NaB could alleviate these pathological lesions, but NaB cannot alleviate pancreatic injury. Our results indicated that NaB could be used for the prevention and adjuvant treatment of diabetic kidney injury.
Diethylene glycol monoethyl ether-mediated nanostructured lipid carriers enhance trans-ferulic acid delivery by Caco-2 cells superior to solid lipid nanoparticles
Authors: Zhang Hongyu , Guo Jingwen , Wang Zhi , Wang Na , Feng Nianping , Zhang Yongtai 
Published: January 2023

Abstract
This work aimed to compare the performance of trans-ferulic acid-encapsulated nanostructured lipid carriers (NLCs) and solid lipid nanoparticles (SLNs) for transport by Caco-2 cells. The NLC particles (diameter: 102.6 nm) composed of Compritol® 888 ATO, ethyl oleate, Cremophor® EL, and Transcutol® P were larger than the SLNs (diameter: 86.0 nm) formed without liquid lipid (ethyl oleate), and the former had a higher encapsulation efficiency for trans-ferulic acid (p < 0.05). In vitro cultured Caco-2 cell transport was used to simulate intestinal absorption, and the cellular uptake of NLCs was higher than that of SLNs (p < 0.05). Compared to SLNs, NLCs greatly enhanced trans-ferulic acid permeation through the MillicellTM membrane (p < 0.05). This work confirms that NLCs have better properties than SLNs in terms of increasing drug transport by Caco-2 cells. This helps to comprehend the approach by which NLC-mediated oral bioavailability of trans-ferulic acid is better than that mediated by SLNs, as shown in our previous report.
Nine-Point Iterated Rectangle Dichotomy for Finding All Local Minima of Unknown Bounded Surface
Authors: Romanuke Vadim 
Published: January 2023

Abstract
A method is suggested to find all local minima and the global minimum of an unknown two-variable function bounded on a given rectangle regardless of the rectangle area. The method has eight inputs: five inputs defined straightforwardly and three inputs, which are adjustable. The endpoints of the initial intervals constituting the rectangle and a formula for evaluating the two-variable function at any point of this rectangle are the straightforward inputs. The three adjustable inputs are a tolerance with the minimal and maximal numbers of subintervals along each dimension. The tolerance is the secondary adjustable input. Having broken the initial rectangle into a set of subrectangles, the nine-point iterated rectangle dichotomy “gropes” around every local minimum by successively cutting off 75 % of the subrectangle area or dividing the subrectangle in four. A range of subrectangle sets defined by the minimal and maximal numbers of subintervals along each dimension is covered by running the nine-point rectangle dichotomy on every set of subrectangles. As a set of values of currently found local minima points changes no more than by the tolerance, the set of local minimum points and the respective set of minimum values of the surface are returned. The presented approach is applicable to whichever task of finding local extrema is. If primarily the purpose is to find all local maxima or the global maximum of the two-variable function, the presented approach is applied to the function taken with the negative sign. The presented approach is a significant and important contribution to the field of numerical estimation and approximate analysis. Although the method does not assure obtaining all local minima (or maxima) for any two-variable function, setting appropriate minimal and maximal numbers of subintervals makes missing some minima (or maxima) very unlikely.
An Approach for Counting Breeding Eels Using Mathematical Morphology Operations and Boundary Detection
Authors: Tran An Cong , Chau Anh Nhut Nguyen , Tran Nghi Cong , Nguyen Hai Thanh 
Published: January 2023

Abstract
The Mekong Delta region of Vietnam has great potential for agricultural development thanks to natural incentives. Many livestock industries have developed for a long time and play an important role in the country with many agricultural export products. In the era of breakthrough technologies and advances in information technology, many techniques are used to support the development of smart agriculture. In particular, computer vision techniques are widely applied to help farmers save a lot of labour and cost. This study presents an approach for counting eels based on Mathematical Morphology Operations and Boundary Detection from images of breeding eels captured with the proposed photo box. The proposed method is evaluated using data collected directly from a breeding eel farm in Vietnam. The authors of the research evaluate and investigate the length distribution of eels to select the appropriate size for counting tasks. The experiments show positive results with an average Mean Absolute Error of 2.2 over a tray of more than 17 eels. The contribution of the research is to provide tools to support farmers in eel farms to save time and effort and improve efficiency.
Integrated Solution to Overcome Work Efficiency Challenges within Trending Remote Work
Authors: Ņikiforova Oksana , Zabiniako Vitaly , Kornienko Jurijs , Garkalns Pāvels , Rizhko Ruslan 
Published: January 2023

Abstract
Estimation of work efficiency is one of the important tasks in company management and analysis of workers’ activities. The environment for determining the efficiency of workers is the use of one or more IS of any kind, within the framework of which the worker’s duties are accomplished. This process can be performed both from home (isolated from the work environment and co-workers) and in the office on-site. Another aspect is related to the fact that a worker can work both with only one IS, or with multiple specialised systems in parallel, which requires the simultaneous integration of several data sources and the parallel reading and analysis of information relevant to worker activities. The task of work efficiency estimation is especially complicated if the company’s activity domain is narrowly specific. In this case, solving such a task of working hour accounting and efficiency estimation is not a trivial accumulation of statistical data, but requires a dedicated method. The work of an engineering system designer is one of the examples of such specific activities. Therefore, exactly this domain was chosen as an application case of the method and metrics proposed in the paper.
Efficient Content-Based Image Retrieval System with Two-Tier Hybrid Frameworks
Authors: Shaheen Fatima , Raibagkar R. L. 
Published: January 2023

Abstract
The Content Based Image Retrieval (CBIR) system is a framework for finding images from huge datasets that are similar to a given image. The main component of CBIR system is the strategy for retrieval of images. There are many strategies available and most of these rely on single feature extraction. The single feature-based strategy may not be efficient for all types of images. Similarly, due to a larger set of data, image retrieval may become inefficient. Hence, this article proposes a system that comprises of two-stage retrieval with different features at every stage where the first stage will be coarse retrieval and the second will be fine retrieval. The proposed framework is validated on standard benchmark images and compared with existing frameworks. The results are recorded in graphical and numerical form, thus supporting the efficiency of the proposed system.
Low levels of awareness of obstructive sleep apnoea amongst the Australian general public
Authors: Chan Emmanuel , Dalci Oyku , Irving Michelle , Byun Roy , Papadopoulou Alexandra K. , Ali Darendeliler M. 
Published: January 2023

Abstract

Introduction: Despite the serious health implications associated with obstructive sleep apnoea, the condition remains under-diagnosed. This study aims to evaluate the awareness of the condition amongst the Australian community.

Methods: A total of 2016 respondents recruited from a web-based panel completed an online questionnaire which assessed awareness and experience of obstructive sleep apnoea and sleep-disordered breathing. The association between the level of awareness and various socio-demographic variables was analysed using uni- and multivariate analyses.

Results: The results of the questionnaire indicated that 50% and 70% of participants were unaware of adult and paediatric obstructive sleep apnoea. Socio-demographic variables including age, annual household income and education level significantly influenced a participant’s level of awareness. Approximately 8.3% of the participants had previously been diagnosed with obstructive sleep apnoea. However, 65% of participants exhibiting symptoms of daytime sleepiness had not sought health care. Paediatric sleep apnoea had been previously diagnosed in 7.1% of children residing in participant’s households but 49% of children with regular snoring had not been medically evaluated.

Conclusion: A deficiency exists in the awareness of sleep apnoea amongst the Australian general public. This is reflected in the discrepancy between the number of participants exhibiting potential symptoms and those who sought medical advice.
Optimal Participation of the Renewable Energy in Microgrids with Load Management Strategy
Authors: Candra Oriza , Chammam Abdeljelil , Rahardja Untung , Ramirez-Coronel Andrés Alexis , Al-Jaleel Abdullah Abdul , Al-Kharsan Ibrahim H. , Muda Iskandar , Derakhshani Ghasem B , Rezai Mohamad Mehdi 
Published: January 2023

Abstract
In this paper, bi-level optimization model is proposed for optimal energy trading between microgrids (MGs) and distribution companies (Discos) with consideration of the renewable energies. The first level modelling is maximizing MGs’ profit and the second level is related to maximization of the Discos profit. In proposed system, power trading between MGs and Discos is considered. As well, renewable energies and demand management strategy are modelled in system for optimal energy consumption. The optimization modelling is solved by Particle Swarm Optimization (PSO), and results of the two case studies show optimal solution of prosed strategy in energy optimization.
Evaluating the Effect of Environment Acidity on Stabilized Expansive Clay
Authors: Jahromi Saeed Ghaffarpour , Noori Ashkan 
Published: January 2023

Abstract
In this article, the effects of environmental acidity on the mechanical and volumetric properties of cement-stabilized clay soils have been investigated through various tests on experimental scale. In this study, a problematic clay was chemically stabilized by cement under three treatment conditions including short term, medium term, and long term with different conditions varying from acid to alkaline environments, which were tested by different methods to evaluate their mechanical and volumetric behavior and properties. Mechanical characteristics assessment tests in this study include compaction tests, and unconfined compressive strength, which was conducted on samples under different conditions in terms of acidity and treatment time. The results of the study indicated that soil improvement by cement increases the mechanical strength and decreases the rate of soil swelling over time and treatment duration. However, the degree of acidity of the environment affects the chemical reactions of soil and cement, especially cement hydration, which causes changes in soil strength and volume variation due to swelling.
Population Pharmacokinetics of Valproate in Children: The Importance of Total Daily Dose, Compliance and Co-Treatment
Authors: Radovanovic Marija , Milovanovic Dragana Dragas , Milovanovic Jasmina R. , Djordjevic Natasa 
Published: January 2023

Abstract
Valproate represents one of the most commonly used anticonvulsants worldwide, whose narrow therapeutic range and high potential for drug-drug interactions leads to pronounced intra- and inter-individual variability in plasma concentration and response. The aim of our study was to apply population pharmacokinetics analysis to comprehensively investigate and detect the most important factors affecting pharmacokinetics of valproate in Serbian children with epilepsy. This retrospective observational study was based on demographic and medical data retrieved from the medical records on epileptic patients treated with valproate at the pediatric department of the Clinical Centre, Kragujevac, Serbia. Valproate serum concentrations were obtained as a part of routine medical practice. Population pharmacokinetics analysis was performed by MonolixSuite 2019R1 (Lixoft, Antony, France) software, using one-compartment model with first order absorption and linear elimination. The study included 1642 valproate concentrations obtained from 232 patients, of which 201 (1420 concentrations) were included in the index set used for the modelling, while the other 31 (222 concentrations) were the validation set used for external validation of the final model. Covariate testing based on the whole index set revealed that only total daily valproate dose significanly affected the clearance of valproate: Cl (l/h)= 0.135×1.002DD. When only compliant patients were included, co-treatment with carbamazepine was shown to be of significance as well: Cl(l/h)=0.121×1.002DD×1.2CBZ. Our study demonstrated that valproate clearance correlates with total valproate daily dose. The influence of co-treatment with carbamazepine on valproate pharmacokinetics can be observed and used for clearance estimation only in compliant patients.
educación STEAM y el aprendizaje lúdico en todos los niveles educativos
Authors: Rodrigues-Silva Jefferson , Alsina Ángel 
Published: January 2023

Se presenta una revisión narrativa de la literatura cuyo objetivo es explorar la relación entre la educación STEAM (acrónimo en inglés de la interdisciplinaridad entre Ciencias, Tecnología, Ingeniería, Artes/humanidades y Matemáticas) y el aprendizaje lúdico. Para ello, se han recolectado y analizado artículos indexados en las plataformas de Web of Science y Scopus. A partir de la revisión realizada, en primer lugar, se presenta brevemente la evolución histórica y las definiciones de estos dos enfoques y, seguidamente, se exploran evidencias de experiencias de educación STEAM a partir de metodologías de enseñanza basadas en el aprendizaje lúdico: el juego libre, el juego guiado, el juego formal y la gamificación. En segundo lugar, se analiza la intersección entre ambos enfoques en torno a la creatividad y se destacan implicaciones para el desarrollo profesional del profesorado. Se concluye que los vínculos entre la educación STEAM y el aprendizaje lúdico son cognitivamente potentes y factibles en todos los niveles educativos; sin embargo, aportan una complejidad al planteamiento didáctico, lo cual requiere conocimientos que el profesorado no tiene y eso puede generar cierta resistencia y conflictos cognitivos. Finalmente, se ha identificado la necesidad de una comprensión más amplia del aprendizaje lúdico, de más investigaciones y de una formación apropiada al profesorado sobre el networking STEAM-lúdico.
Dinamika Tahapan Pengembangan Masyarakat oleh Junaedi Mulyono di Desa Ponggok, Klaten, Jawa Tengah
Authors: Wihayati Anisa 
Published: January 2023

Melakukan pembedayaan masyarakat demi meningkatkan taraf hidup masyarakatnya adalah salah satu tugas dari kepala daerah. Melakukan pembedayaan masyarakat demi meningkatkan taraf hidup masyarakatnya adalah salah satu tugas dari kepala daerah. Terdapat salah satu kepala daerah yang sukses dalam melakukan pengembangan masyarakat. Tulisan ini, hendak memamparkan tahapan-tahapan pengembangan yang dilakukan Kepala daerah tersebut serta dinamika dalam tiap tahapan dalam pengembangan masyarakat di Desa Ponggok. Metode penelitian yang digunakan adalah kualitatif dengan menggunakan studi pustaka. Dari penelitian ini dapat diketahui bahwa mulai dari tahapan awal persiapan sudah ada tantangan yaitu dari objek yang diberdayakan yang tidak yakin dengan program pengembangan dapat diwujudkan, hingga pelaksanaan bahkan sampai ada opini penyelewengan. Dinamika pengembangan yang mau tak mau harus dilewati dan sukses dilewati oleh Junaedi Mulyono hingga kini desa Ponggok bahkan menjadi desa percontohan untuk pengembangan desa wisata.
Depresi dan Kecemasan Remaja Ditinjau dari Perspektif Kesehatan dan Islam
Authors: Muslimahayati Muslimahayati , Rahmy Hafifatul Auliya 
Published: January 2023

Depresi dan kecemasan merupakan suatu kondisi mental yang menjadi penyebab terbesar dari beban penyakit dan kecatatan yang dihadapi oleh remaja. Dalam perkembangannya saat ini, hal tersebut penting untuk dibahas terutama ditinjau dari perspektif Kesehatan dan islam. Metode yang digunakan dalam penulisan studi literatur ini melalui penelusuran internet dari database Google Scholar dari tahun 2011-2021-sekarang dengan menggunakan kata variabel depresi dan kecemasan pada remaja. Dapat disimpulkan bahwa kesehatan mental menjadi salah satu hal yang penting untuk menunjang keberlangsungan hidup seseorang. Melalui peningkatan religiusitas, seseorang akan lebih optimis dan memiliki pemikiran yang positif dalam menghadapi keadaan. Di dalam Islam, semakin seseorang mendekatkan diri kepada Allah SWT maka akan semakin tentram pula jiwanya serta terhindar dari berbagai penyakit fisik maupun jiwa.
MENINGKATKAN KEMAMPUAN MOTORIK HALUS ANAK USIA DINI MELALUI AKTIVITAS MONTASE
Authors: Huda Huda , Saniya Siti , Kasmadi Nurmalia 
Published: January 2023

Aktivitas montase merupakan kegiatan yang sangat baik untuk melatih meningkatkan kemampuan motorik halus anak. Jenis penelitian ini adalah penelitian tindakan kelas kolaboratif dengan menggunakan Model Kemmis dan Mc Taggart. Subjek penelitian adalah anak kelompok B2 yang berjumlah 15 anak terdiri dari 7 anak laki-laki dan 8 anak perempuan. Metode pengumpulan data yang di gunakan adalah observasi, dokumentasi, dan wawancara. Hasil penelitian menunjukan bahwa pada aktivitas montase anak dapat meningkatkan kemampuan motorik halus anak dan setelah adanya tindakan melalui aktivitas montase. Pada siklus I pertemuan 1 presentasi keterampilan pada aktivitas montase anak sebesar 13% yang berkembang sangat baik. Pada siklus II pertemuan I presentasi keterampilan pada aktivitas montase anak sebesar 86% yang berkembang sangat baik,perolehan presentase tersebut menunjukkan bahwa keterampilan pada aktivitas montase anak kelompok B2 dengan kriteria sangat baik telah mencapai indikator keberhasilan sebesar 86%.