bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of ferroptosis-related prognostic models and FDFT1 as a potential ferroptosis driver in colorectal cancer
Authors: Duan Lili , Cao Lu , Liu Jinqiang , Wang Zixiang , Liang Jie , Feng Weibo , Liu Yi , Feng Fan , Zhang Jian , Zheng Jianyong 
Published: August 2023

Abstract
Background: Prediction of colorectal cancer (CRC) prognosis is challenging. Ferroptosis constitutes a newly reported kind of cell death, and its association with CRC prognosis remains unexplored. Herein, we aimed to develop ferroptosis-related gene (FRG) signatures to predict overall survival (OS) along with disease-free survival (DFS) in individuals with CRC.
Methods: The clinical data and mRNA expression were extracted from the TCGA web data resource. The Lasso algorithm was utilized to construct the OS and DFS prediction signatures. Independent data from GSE38832 were used for verification.
Results: Our findings revealed there was a discrepancy in the expression of 85% of FRGs between CRC and healthy tissues. Among them, 11 prognostic genes were identified using UniCox analysis. Predicted risk scores from the two models stratified patients into low- as well as high-risk groups and were demonstrated as independent prognostic factors using MultiCox analysis. The efficacy of the models was verified using ROC curve analysis. Functional enrichment analysis indicated that cancer-linked pathways were abundant in the high-risk group, and that immune status differed between the two risk groups. The CMap web data resource helped in identifying a total of sixteen potential drugs. In addition, FDFT1 was proved to play an anti-tumor role in CRC and may promote ferroptosis by regulating the expression of ISCU.
Conclusions: Our FRG-based prognostic models are reliable predictive tools for CRC patients, suggesting that FRGs may be potential targets for CRC therapy.
Variation in water use by mammals in Khao Phaeng Ma Non-hunting Area, Thailand
Authors: Chaiyarat Rattanawat , Thongkrathok Piyamaporn , Maisuwan Wanwipa , Chantra Amornrat , Chimplee Jinda , Cheachean Navee , Assawaklang Songkrit , Youngpoy Namphung 
Published: August 2023

AbstractBackground Access to suitable water sources is important for mammals. This study compared species diversity and the water use by mammals among water springs, standard artificial ponds, and water pans within the Khao Phaeng Ma Non-Hunting Area in 2020 and 2021. Methods Two camera traps were installed at each water sources for 749 nights with a total of 12 water sources. A total of 19,467 photographs were recorded comprising 13,777 photographs of gaur (Bos gaurus, the vulnerable and most important in the area), and 5,690 photographs of other mammals. Results In the wet seasons of 2020 and 2021, the relative use was highest at standard artificial pond number 2 and water pan number 1. In the dry seasons of 2020 and 2021, the relative use was highest at water pan number 1 and 2. During the study period, the number of species was highest in water pan number 1 (10 species, diversity index (H´) = 1.38), and water pan number 2 (11 species,H´= 1.75). Gaur, sambar deer (Rusa unicolor), red barking deer (Muntiacus vaginalis), wild boar (Sus scrofa), and Asian black bear (Ursus thibetanus) used water pan and standard artificial pond rather than water spring. Conclusions The use of water spring was associated with water period (months), while standard artificial pond and water pans were associated with water surface area, water depth, altitude, species diversity, species richness, and number of mammals photographed. Water pans were more suitable for utilization by mammals than other water sources.
Change in macular perfusion after surgical treatment in patients with idiopathic macular hole: a retrospective cohort study
Authors: Liu Weixian , Chen Chunmei , Huang Xionggao , Wang Ling 
Published: August 2023

Abstract

Objective
To investigate prognostic predictive value of postoperative change in macular perfusion for idiopathic macular hole (IMH).
Methods
IMH patients who received posterior vitrectomy with internal limiting membrane peeling and gas tamponade were retrospectively included. Macular perfusion evaluated by vessel density and capillary perfusion density were collected from examination records of optical coherence tomography angiography (OCTA) performed before and after surgical treatment. Postoperative improvement in best-corrected visual acuity (BCVA) was studied as the outcome. Multivariable logistic regression was employed to investigate the association between change in macular perfusion and the outcome after adjusting for preoperative characteristics.
Results
Fifty-two eyes of 52 patients (71.2% female) were included into the analyses, with a mean age of 59.7 ± 6.6 years old and a mean basal macular hole diameter of 913.8 ± 250.4 µm. Vessel density increased from 17.3 ± 2.3 mm-1 to 18.1 ± 2.6 mm-1 one month after surgical treatment (P < 0.001), and capillary perfusion density increased from 36.8 ± 7.7% to 47.3 ± 11.1% (P < 0.001), together with an improvement in BCVA (logMAR from 1.2 ± 0.2 to 0.6 ± 0.4, P < 0.001). Results of univariable linear regress suggested poor preoperative BCVA and large macular hole size were associated with poor postoperative BCVA. After taking these variables into account, multivariable logistic regression suggested greater increase in capillary perfusion density was associated with better improvement in preoperative BCVA, but such an association was not observed in the change in vessel density.
Conclusion
Change in capillary perfusion density assessed with OCTA as a proxy for macular perfusion may be used as a prognostic predictor of IMH patients who received surgical treatment.
Renal Medullary Oxygenation during Laparoscopic vs Open Surgery: The Impact of Blood Pressure Management. A pilot randomized controlled trial
Authors: Chaba Anis , Hacking Doug , Slifirski Hugh , Cogan Rebecca , Spano Sofia , Maeda Akinori , Eastwood Glenn , Bellomo Rinaldo 
Published: August 2023

Abstract
Purpose
The impact of blood pressure targets and surgical approach (laparoscopic or open) on continuous urinary oxygenation (PuO2), a validated surrogate of renal medullary PO2, during general surgery, is unclear. We aimed to assess the effects of different blood pressure targets and surgical procedures on PuO2.
Methods
We randomized patients receiving either laparoscopic or open surgery into two mean arterial pressure (MAP) target groups: usual MAP or a high MAP. We measured PuO2 in real-time and analyzed it according to the type of surgery and blood pressure target. The study was retrospectively registered on the 5th of July 2023 (ACTRN12623000726651).
Results
We included 43 participants who underwent either laparoscopic (n = 20) or open surgery (n = 23). We found that PuO2 significantly decreased during both laparoscopic and open surgery under a usual blood pressure target (-51% and − 49%, respectively). However, there was a sharper fall with laparoscopic surgery resulting in a higher PuO2 with open surgery (mean difference: 11 ± 1 mmHg higher; p < 0.001). Targeting a higher MAP resulted in a higher PuO2 over time during laparoscopic surgery (mean difference: 7 ± 1 mmHg, p < 0.001). In contrast, targeting a usual MAP resulted in a higher PuO2 during open surgery (mean difference: 7 ± 1 mmHg, p < 0.001).
Conclusion
Surgical approach and intraoperative blood pressure targets significantly impact urinary oxygenation. Further studies with larger sample sizes are needed to confirm these findings and understand their potential clinical implications.
Transformation of mothers’ values through an online multidisciplinary group consultation on pregnancy and childcare: The Trajectory Equifinality Approach
Authors: Tani Haruka , Sugao Shoko , Kitabatake Yasuji , Matsuzaki Masayo , Nakamoto Goji , Endo Masayuki 
Published: August 2023

Abstract
In Japan, developing concrete support for mothers facing child-rearing difficulties and anxiety has become an important social issue. Moreover, with the onset of the COVID-19 pandemic, the availability of support previously received by mothers had become limited. To address this issue, an online group consultation involving multidisciplinary specialists was conducted at the Osaka University. This study aimed to examine how participants’ childcare anxiety and child-rearing difficulties experienced prior to group consultation changed after their participation, and to identify the factors that facilitated this transformation. Semi-structured interviews were conducted with group consultation participants and analyzed using the Trajectory Equifinality Approach. The findings revealed a process whereby mothers who harbored worries regained their confidence and raised their children with peace of mind, through the affirmation they received from professionals and other participants. Additionally, mothers who held values emphasizing perfection and correctness in child-rearing experienced these transformed into values that brought personal fulfilment. These findings indicate that such group consultations can function as a platform to foster peace of mind and confidence in parenting.
Atmospheric Carbon Dioxide Measurement Using 1.5-µm Double- Pulse IPDA lidar over the Desert
Authors: Fan Chuncan , Yang Juxin , Liu Jiqiao , Bu Lingbing , Wang Qin , Wei Chong , Zhang Yang , Zhu Xiaopeng , Li Shiguang , Zang Huaguo , Chen Weibiao 
Published: August 2023

Abstract
The Integrated Path Differential Absorption (IPDA) lidar is capable of accurately measuring regional carbon dioxide (CO2) column concentrations, which is crucial for understanding the carbon cycle in the biosphere and predicting future climate change. The space-borne IPDA lidar has become the preferred sensor for measuring global CO2 column concentrations(XCO2) on days and nights. To validate the data processing methods of space-borne lidar, an airborne IPDA lidar was designed for a flight experiment.In July 2021, the airborne experiment was implemented in Dunhuang, Gansu Province, China (39–41°N, 93–96°E), where the aircraft was equipped with a developed lidar that could measure both aerosols profiles and CO2 concentrations, a wind measurement lidar, and an in-situ greenhouse gas analyzer (GGA). To minimize measurement errors, the energy monitoring part was optimized. The differential absorption optical depth (DAOD) was calculated using the Pulse Integral Method (PIM) algorithm, and the CO2 column-averaged dry-air mixing ratio was calculated using various averaging methods. The IPDA lidar measured XCO2 over the Dunhuang validation site to be 405.572 ppm, with a long-term correlation coefficien of 91.2% with the GGA. Furthermore, the IPDA lidar and the LGR both measured changes in XCO2 concentration resulting from aircraft exhaust.
Detoxification of tequila vinasse by Trametes sanguineus: a biotechnological approach to laccase production and water reuse in seedling growth
Authors: Teymennet-Ramírez Karla , García-Morales Soledad García-Morales , Hernández-Fernández Overlin , Barrera-Martínez Iliana 
Published: August 2023

Abstract
Tequila vinasse, a by-product generated during agave fermentation, is a wastewater characterized by its dark color and composition, which includes water, alcohol, sugars, phenolic compounds, proteins, among others. Its high chemical oxygen demand (COD) and pH levels classify it as hazardous to the soil, plants, and aquatic organisms, requiring the development of treatment strategies or proper disposal methods. It is worth noting that vinasse contains numerous compounds that can be recovered and valorized. In this study, different concentrations of tequila vinasse (100%, 70%, and 50%) were subjected to a 10-day treatment with Trametes sanguineus. Significant reductions in color, phenolic content, and COD were observed across all conditions, with approximately 70% decolorization and 60% reduction in phenolic content achieved. Among the different conditions tested, the 50% concentration exhibited the highest laccase production, reaching approximately 1,779 U/L on the 5th day of cultivation, while laccases were also detected in the other conditions. Subsequently, the potential of the treated vinasse for germination and seedling growth was assessed. Trametes sanguineus was removed from the vinasse, and the resulting supernatant was applied directly to the seeds. Lettuce and tomato seeds were employed in these assays, both of which demonstrated seed germination rates ranging from 50–80%, respectively. Notably, vinasse without T. sanguineus treatment did not exhibit any germination. Additionally, seedling growth assays were conducted, revealing that the treated vinasse supported the growth of tomato and lettuce plants, with root-related features comparable to the control. Valorization of agroindustrial waste presents a viable approach for obtaining value-added products.
Long term survival at 6 and 12 months in venous thromboembolic disease in patients anticoagulated with rivaroxaban and warfarin: propensity score matching study
Authors: Ramos-Isaza Estefan , Tuta-Quintero Eduardo , Bastidas-Goyes Alirio , Diaz-Quijano Diana , Aponte Carolina , Angel Julian Manuel Espitia , Beltran Daniel Andrés Pinto , Rincón-Hernández Johan , Sánchez-Cuellar Juan , Pérez-Bueno Jesus , Cadavid Luis F. Giraldo 
Published: August 2023

Abstract
Background: Venous thromboembolic disease (VTE) is characterized by the obstruction of venous blood flow by a thrombus, whose survival data and clinical outcomes, such as disease recurrence and bleeding in patients with warfarin anticoagulant therapy compared with rivaroxaban in the Latin American population is limited.
Methods: A retrospective cohort study with propensity score matching analysis was conducted in patients with VTE anticoagulated with warfarin or rivaroxaban treated. The radiological report defined VTE with a confirmed diagnosis of pulmonary embolism and deep ve. Survival analysis was performed using a Kaplan-Meier curve for each of the intervention groups, and it was compared using a log-rank test.
Results: Of 2193 potentially eligible patients with a suspected diagnosis of VTE, 505 patients entered the analysis; of these, 285 subjects were managed with warfarin and 220 anticoagulated with rivaroxaban. Bleeding at six months occurred in 2.7% (6/220) of patients on rivaroxaban vs. 10.2% (29/258) on warfarin in the unmatched population (p=0.001) and in 2.9% (6/209) with rivaroxaban and 11.0% (23/209) with warfarin in the pairing (p=0.001). At 6 and 12 months, there was a survival of 97.1% for rivaroxaban and 97.6% for warfarin 97.6% (p=0.76), and 94.7% for rivaroxaban and 95.7% for warfarin (p=0.61), respectively.
Conclusion: Rivaroxaban, compared to warfarin in VTE management, has no impact in terms of survival at 6 and 12 months, nor a decrease in the occurrence of new thromboembolic episodes. However, it decreases the risk of bleeding at six months.
Hybridization of aluminium-silicon alloy with boron carbide and ferrotitanium and the effect on mechanical properties as auto-material
Authors: Oladosu Oluwafemi Timothy , Akinwande Abayomi Adewale , Adesina Olanrewaju , Sanyaolu Olufemi Oluseun , Obadele Babatunde Abiodun 
Published: August 2023

Abstract
The brittle nature of ceramic reinforcement in metal matrixes has initiated a gap in the utilization of metal-based particles as supplementary reinforcement. This present study investigated the influence of adding FeTi as supplementary reinforcement to B4C and FeTi in an aluminum-silicon (Al-12Si) matrix for automobile applications. The FeTi alloy was introduced at 3, 6, and 9 wt.% alongside the 5 wt.% B4C particles. The effect of such an addition on the morphology, physical, and mechanical properties was examined. The X-ray diffraction pattern identified the presence of B4C and FeTi reinforcing phases alongside Al3Fe and Ti5Si3 phases. The examined morphology revealed that the particles were well dispersed in the matrix, with consequent effects on their properties. Porosity was reported to reduce linearly with a rise in FeTi dosage, consequently engendering a linear rise in density and relatively high density. Inclusive of the hardness, the yield and ultimate strength were enhanced progressively upon a progressive rise in FeTi dosage, with a contrary reduction in ductility. The result revealed that the inclusion of FeTi reinforcing fillers in the matrix is capable of causing an appreciable improvement in the mechanical properties of the composite.
Intrinsic capacity trajectories and socioeconomic inequalities in health: the contributions of wealth, education, gender, and ethnicity
Authors: Salinas-Rodríguez Aaron , Fernández-Niño Julián Alfredo , Rivera-Almaraz Ana , Manrique-Espinoza Betty 
Published: August 2023

Abstract
Background
Life-long health inequalities exert enduring impacts and are governed by social determinants crucial for achieving healthy aging. A fundamental aspect of healthy aging, intrinsic capacity, is the primary focus of this study. Our objective is to evaluate the social inequalities connected with the trajectories of intrinsic capacity, shedding light on the impacts of socioeconomic position, gender, and ethnicity.
Methods
Our dynamic cohort study was rooted in three waves (2009, 2014, 2017) of the World Health Organization's Study on Global AGEing and Adult Health in Mexico. We incorporated a nationally representative sample comprising 2722 older Mexican adults aged 50 years and over.
Baseline measurements of socioeconomic position, gender, and ethnicity acted as the exposure variables. We evaluated intrinsic capacity across five domains: cognition, psychological, sensory, vitality, and locomotion. The Relative Index of Inequality and Slope Index of Inequality were used to quantify socioeconomic disparities.
Results
We discerned three distinct intrinsic capacity trajectories: steep decline, moderate decline, and slight increase. Significant disparities based on wealth, education level, gender, and ethnicity were observed. Older adults with higher wealth and education typically exhibited a trajectory of moderate decrease or slight increase in intrinsic capacity. In stark contrast, women and indigenous individuals were more likely to experience a steeply declining trajectory.
Conclusions
These findings underscore the pressing need to address social determinants, minimize discrimination, and confront structural racism to ensure equal access to resources and opportunities across the lifespan. It is imperative for policies and interventions to prioritize these social determinants in order to promote healthy aging and alleviate health disparities. This approach will ensure that specific demographic groups receive customized support to sustain their intrinsic capacity during their elder years.
A novel architecture for collaboration in systems biology at the age of the Metaverse
Authors: Jacopin Eliott , Sakamoto Yuki , Nishida Kozo , Kaizu Kazunari , Takahashi Koichi 
Published: August 2023

Abstract
The current state of the Metaverse is largely driven by corporate interests, which may not align with the scientific goals and values. Hence, academia should play a more active role in its development. In this paper, we present the challenges and solutions for building a Metaverse that supports systems biology research and collaboration. Our solution consists of two components: Kosmogora, a server ensuring biological data access, traceability, and integrity in the context of a highly collaborative environment such as a metaverse; and ECellDive, a virtual reality application to explore, interact, and build upon the data managed by Kosmogora. We illustrate the synergy between the two components by visualizing a metabolic network and its flux balance analysis. We also argue that the Metaverse of systems biology will foster closer communication and cooperation between experimentalists and modelers in the field.
Opening the wormhole: Linkages between justice in energy transitions and energy systems modelling literature – implications for policy development
Authors: Sefid N. , Okamoto T. , Doyon A. , Niet T. 
Published: August 2023

Abstract
Sometimes academics from different disciplines feel like they are working on different planets that orbit stars lightyears apart. Justice in energy transitions and the energy modelling literatures are no exception. While both fields share a common focus on realizing a sustainable and equitable future, rarely do equity and justice considerations enter modelling studies, and vice versa, rarely do papers consider modelling and engineering analysis enter into the justice in energy transitions field. This paper documents collaborative research conducted by justice in energy transitions and energy modelling researchers Through literature reviews and collaborative dialogue, we identified overlaps between justice in energy transitions and energy modelling and set an initial research agenda. By opening the wormhole connecting our fields, we hope to inspire more transdisciplinary research and inform future justice-oriented energy policy. We call on fellow justice in energy transitions and energy modelling researchers to join us in learning from one another and working towards a more sustainable and just future. We also call on policymakers to utilize transdisciplinary research to inform just energy futures.
Demand analysis of home care services among breast cancer survivors based on the Kano model
Authors: Zhang Mao-mao , Zhang Liu-liu , Zhi Xiao-xu , Cheng Fang , Yao Yu-feng , Deng Rong , Liu Chun-li , Wang Yan , Pei Yi 
Published: August 2023

Abstract
Purpose
Home-based nursing care services can effectively alleviate the pressure of medical and social services caused by the increasing number of breast cancer survivors. However, the precise definition and scope of home care services for breast cancer survivors remain unclear. The aim of this study was to explore the home care services for breast cancer survivors based on the Kano model to improve the quality of care services.
Methods
A convenience sampling was used to select breast cancer survivors from January 2023 to March 2023 in Jiangsu Cancer Hospital in Nanjing, Jiangsu Province, China. Participants completed a social demographic characteristics questionnaire, and their home nursing service needs were assessed using the Kano model. The home care attributes of the participants were categorized and described based on the Kano model.
Results
A total of 299 valid questionnaires (88.9%) were collected, evaluating 30 quality attributes of home care services. The findings revealed that 1 (3.3%) service was classified as "must-be quality" (body image management), 13 (43.33%) as "one-dimensional quality", 7 (23.33%) as "attractive quality" (focused on health management and guidance services), and 9 (30%) as "indifferent quality" (mainly in the area of psycho-social support).
Conclusion
Based on the Kano model, it was found that breast cancer survivors had different level of need for different home care service. Analyzing breast cancer survivors attitudes toward new service items for indifference quality will help service providers determine effective tactics in home care services.