bluuebunny/crossref_metadata_2025_split huggingface dataset:
Digenean trematodes (Trematoda: Digenea) parasitizing the digestive system of the great cormorant (Phalacrocorax carbo) in Hungary
Authors: Gyöngy M. , Juhász L. , Sellyei B. , Székely C. , Cech G. 
Published: February 2025

Summary
Great cormorants (Phalacrocorax carbo) are widespread piscivorous birds, which cause huge economic losses in the fish fauna worldwide. As a consequence of their predatory behaviour, they serve as definitive hosts for many digenean trematodes, and their digestive systems usually contain several parasite species.
Between 2019 and 2022, 131 bird carcasses were collected from Biharugra (Hungary) as culling on the cormorant population. Their digestive systems were subjected to parasitological examination. The studied organs (131 intestines, 44 stomachs and 21 pharynxes) were opened, and their contents were settled in water, filtered, and sorted under microscope. For species identification, sequence analysis of the ITS region was performed. Of the 131 birds, 118 were infected by tapeworms or nematodes, 105 with trematodes, and 10 were parasite-free.
The vast majority of obtained sequences (57 of the 105 trematodes) belonged to the genus Petasiger (43/57) and Hysteromorpha triloba (13/57). A single specimen of Metorchis sp. (1/57) as a zoonotic trematode was recorded during our survey. The results confirmed the high trematodes prevalence of the examined cormorants. However, most of them are not considered as human pathogens.
Studies on the significance of secretory IgA antibodies in the pathogenesis and clinical course of enterobiasis in infected persons from Bulgaria: preliminary findings
Authors: Kaneva E. , Harizanov R. , Velcheva D. , Tsvetkova N. , Pavlova M. , Alexiev I. , Dimitrova R. , Videnova M. , Borisova R. , Ivanova A. 
Published: February 2025

Summary
Enterobiasis is one of the most common human parasitic infections worldwide and in Bulgaria. The objective of this study was to ascertain the levels of intestinal secretory IgA antibodies in patients with enterobiasis, to determine the local immune response in this helminthiasis, and to evaluate its influence on clinical manifestations during infection.
Faecal samples from 102 enterobiasis patients and 40 clinically healthy controls were examined. In individuals infected with Enterobius vermicularis, the range of values for SIgA was higher (from 27.5 μg/ml to 13916 μg/ml). However, no statistically significant difference was found between them and those in persons without evidence of infection (from 27.5 to 8999 μg/ml). In both groups of individuals (infected and non-infected), we observed differences in the levels of SIgA, which appeared to be dependent on the age and gender of the subjects. Significantly, higher values were observed in children and adolescents, as well as in males. In individuals with enterobiasis, a higher level of SIgA was observed in those with pronounced clinical symptoms (mean value = 2198.74) compared to asymptomatic individuals (mean value = 1588.54). The highest levels were observed in patients presenting with perianal pruritus (mean value = 3559.54).
Our study of the local humoral immune response in people with enterobiasis is the first of its kind in the country. The results clearly show a direct correlation between the presence of clinical symptoms in enterobiasis and elevated levels of secretory IgA in faeces.
A Survey of Distributed Ledger Technologies in the Health Domain
Authors: Khan Ikramullah , Phuyal Sudip , Correia Ricardo , C. Ferreira Joao 
Published: February 2025

Abstract
Healthcare providers face critical challenges in managing and exchanging patient health and medical records. Traditional health and medical data management systems, which often include paper-based records and work as closed, isolated silos, have demonstrated limitations in terms of data usability, interoperability, and patient privacy. This translates into limitations not only for providers but also for the patients, healthcare professionals, and other participants of the health-care value chain, hindering potential innovations and efficiency gains. Distributed Ledger Technology (DLT), such as the blockchain, is emerging as a possible solution to challenges in data management and beyond across several operational and administrative processes in healthcare services. This paper begins with an extensive overview of the literature with an emphasis on DLT implementations and applications in the healthcare industry. We examine how DLT has been used in real-world initiatives across the healthcare domain, highlight notable initiatives, and outline potential improvements. This may result from its adoption, namely in areas such as healthcare data sharing and interoperability, verifiability, transparency, or patient privacy and control. Overall, some of DLT’s native capabilities, such as data immutability, sharing and reconciliation across parties with varying levels of trust, and user self-sovereignty may translate into solutions for several caveats of the current healthcare technological infrastructures, and contribute to improving healthcare outcomes by fostering innovations, enabling broader sharing of healthcare data, enhancing transparency over the use of data, equipping patients with greater control over their data, and enabling new or improved services and processes in healthcare.
Comprehensive Review on Social and Environmental Practices in GVCs
Authors: Belabbas Iméne 
Published: February 2025

Abstract
Global value chains (GVCs) have become a key framework for understanding the complexities of international production divisions and sustainability outcomes. Despite their potential for enhancing sustainability, GVCs often present mixed economic, environmental, and social impacts due to the specialization and scale effects of offshoring and international trade. This paper systematically reviews the literature on sustainability in GVCs, focusing on the interplay between economic, environmental, and social outcomes. Drawing on a content analysis of over 74 articles published between 2010 and 2023, we identify key trends, theoretical frameworks, and gaps in the current body of knowledge. Our findings reveal that while GVCs can enhance sustainability and reduce social inequalities through improved technologies and practices, they also contribute to carbon leakage and the uneven distribution of social benefits. We propose a conceptual integrative model that incorporates these findings and offers directions for future research, particularly in addressing industry-specific sustainability challenges and the need for more equitable social and environmental outcomes in both emerging and advanced economies.
Autoxidation von Cu<sup>I</sup>-Komplexen, II: Mechanismus der Autoxidation von Komplexen mit einzähnigen Stickstoffliganden
Authors: Zuberbühler A. 
Published: February 2025

The autoxidation of cuprous complexes with monodentate nitrogeneous bases (L) has been studied spectrophotometric-ally and by following the O2-consumption with an oxygen sensor. The proposed mechanism includes two different oxygenated species. CuL2O2+ is less reactive than CuL3O2+ by many powers of magnitude which is explained by the fact that CuL2O2+ has a coordination number of 3, specific for CuI, whereas CuL3O2+ may gain quasiplanar, CuII specific, symmetry by molecular vibration.
Pengembangan Media Game Edukasi â€œAnimal and Plantâ€ Untuk Pembelajaran Nama Hewan dan Tumbuhan
Authors: Affandi Akhmad Syafroni 
Published: February 2025

Penelitian ini menghasilkan game edukasi animal and plant berupa game edukasi berbasis computer menggunakan UNITY. Pembelajaran dilakukan secara konvensional dengan metode ceramah dan siswa mengerjakan soal latihan, maka perlu dikembangkan model pembelajaran yang lebih kreatif dan inovatif. Game edukasi yang dirancang diharapkan bisa meningkatkan hasil belajar dan prestasi siswa pada mata pelajaran Bahasa Indonesai khususnya materi pengenalan nama hewan dan tumbuhan. Jenis data dalam penelitian ini adalah (1) hasil validasi ahli media (2) hasil validasi ahli materi, dan (3) data hasil uji coba kelompok kecil. Validasi oleh ahli media mendapatkan nilai 84%, dengan nilai sebesar 84% dengan produk ini bisa digunakan oleh pendidik dan peserta didik dengan tanpa revisi. Validasi oleh ahli materi diperoleh nilai sebesar 78%, dengan nilai tersebut produk ini bisa digunakan oleh pendidik dan peserta didik dengan revisi sesuai saran uji coba kelompok kecil dengan sejumlah siswa sebanyak 10 anak memperoleh nilai 84%, dimana dengan angka tersebut produk ini layak untuk digunakan sebagai media pembelajaran.Â This research produced an animal and plant educational game in the form of a computer-based educational game using UNITY. Learning is done conventionally with the lecture method and students work on exercises, it is necessary to develop more creative and innovative learning models. The educational game that is designed is expected to improve student learning outcomes and achievements in Indonesian subjects, especially the material recognition of animal and plant names. The types of data in this study are (1) the results of the validation of the media experts (2) the results of the validation of the material experts, and (3) the results of the small group trial data. Validation by media experts gets a value of 84%, with a value of 84% with this product can be used by educators and students with no revisions. Validation by material experts obtained a value of 78%, with this value this product can be used by educators and students with a revision according to the suggestion of a small group trial with a number of students as many as 10 children scored 84%, which with these numbers the product is suitable for use as a learning medium
STUDENTS AND READINESS TO FACE THE WORLD OF WORK
Authors: Hidayah Dita Nisaul 
Published: February 2025

This article examines students' readiness to face the world of work. As stated by the Indonesian Minister of Education and Culture, Nadiem Anwar Makarim, B.A., M.B.A., that 80% of Indonesian students do not work according to their major. This statement suggests that the diploma obtained is not in accordance with the demands of the world of work. So the problem is how the government will try to resolve the gap between graduates and employment opportunities. And how prepared students are to face the world of work after graduating. The article is based on the results of random online open interviews with students at several universities in Surabaya. The results of the interviews show that students generally want to be able to work according to the disciplines they obtained at college or the diploma they obtained. And students hope that there will be efforts from the government to create jobs that suit their majors or changes to the curriculum that lead to a connection between education and work life.
Game-Based Learning for Mathematics Lesson on 3rd Grade Elementary School
Authors: Tanudidjaja Miquel Jan , Pranata Caraka Aji , . Bernadhed 
Published: February 2025

Integrating cutting-edge strategies to improve students' learning experiences has become increasingly important in the ever-changing world of education. This study investigates how third-grade students at SD Pius Purbalingga can benefit from using game-based learning as an instructional strategy to improve their mathematical education. The study focuses on how to hold children' attention and improve their knowledge of mathematics. The main subject of this study is the effectiveness of educational games in enhancing elementary school student's understanding of mathematics. A mathematics game was created to solve this problem by actively involving pupils and reiterating key mathematical ideas. This game-based strategy aimed to create an engaged and enjoyable learning experience for third-grade pupils with acceptable cognitive capacities. The findings suggest that students who played the math game significantly increased their involvement, comprehension, and memorization of mathematical ideas. This study adds to the growing evidence supporting using educational games as useful tools in mathematics instruction. The study's findings revealed increased academic performance among students, with male students experiencing a rise of 2.4% in their overall scores. In contrast, female students demonstrated a significantly higher increase of 8.5%, indicating a more pronounced advancement in their academic performance.
APPLICATION OF CLIMATE SMART AGRICULTURE IN THE IMPLEMENTATION OF THE PRIMADONA PROGRAM (SUSTAINABLE INNOVATIVE INDEPENDENT MANGO FARMING)
Authors: Adinda Aulia Nur Afifah  , Riezqi Fajar  , Arfianto Trisnawan  
Published: February 2025

Perubahan iklim berpengaruh terhadap pergeseran musim menjadi salah satu faktor menurunnya produktivitas pertanian mangga. Artikel ini bertujuan untuk mengetahui implementasi Program PRIMADONA (Pertanian Mangga Mandiri Inovatif Berkelanjutan) binaan PT Pertamina Patra Niaga Integrated Terminal Balongan melalui pendekatan Climate Smart Agriculture. Program PRIMADONA merupakan program Corporate Social Responsibility (CSR) PT Pertamina Patra Niaga Integrated Terminal Balongan dalam bidang pemberdayaan petani mangga di Desa Sliyeg Lor, Indramayu dengan fokus kegiatan pengembahan pertanian mangga tahan iklim. Artikel ini menggunakan pendekatan kualitatif deskriptif. Adapun data yang dipakai menggunakan data primer dan sekunder yang bersumber dari wawancara dan studi literatur. Hasil penelitian ini menunjukkan bahwa implementasi Program PRIMADONA telah menerapkan prinsip pendekatan Climate Smart Agriculture yakni 1) meningkatkan produktivitas pertanian; 2) adaptasi untuk membangun ketahanan terhadap perubahan iklim; 3) mengurangi gas rumah kaca (GRK). PT Pertamina Patra Niaga Integrated Terminal Balongan berupaya meningkatkan produktivitas pertanian melalui metode tumpangsari, budidaya mangga di dalam greenhouse serta pengelolaan pasca panen melalui pengolahan produk turunan mangga. Upaya adaptasi dan mitigasi untuk membangun ketahanan perubahan iklim dalam Program PRIMADONA diimplementasikan melalui pengembangan smart greenhouse berbasis Internet of Things (IoT). Pengurangan sumbangan gas rumah kaca dilakukan dengan penggunaan pupuk organik dalam budidaya mangga serta penerapan zero waste dalam pengelolaan limbah pertanian. Keterlibatan kelompok sosial masyarakat, pelibatan wanita, lansia dan petani milenial turut menjadi elemen penting dalam pelaksanaan skema kegiatan Program PRIMADONA.
OPEN DATA USAGE AND DIGITAL LITERACY LEVEL OF PEOPLES IN TANGERANG REGENCY
Authors: Ahmad Khumaeni Zhakaria  , Ray Septianis Kartika  , Nurkholish Majid  
Published: February 2025

The era of digitalization requires an innovative and accountable government. Tangerang Regency has a variety of applications that are realized to accelerate services and good governance as a whole. One of them is through open government data, which is easily accessible by any party to achieve a goal, namely transparency and disclosure of information. The purpose of this study is to determine the level of digital literacy of the community and the extent of their use of the open data portal. This research uses a mixed method with quantitative analysis using a Likert scale. The population and sample of the study were the people of Tangerang district aged between 18 and 60 years old, domiciled in Tangerang, and had used the district's open data portal. The results of this study indicate that although most people in Tangerang district have relatively high digital literacy skills, they still do not fully utilize this tool in the context of using the open data portal. This is due to several factors such as lack of public awareness, socialization from the government, and features that are not fully optimized.
Temporal dynamics of ICP, CPP, PRx, and CPPopt in relation to outcome in spontaneous intracerebral hemorrhage
Authors: Kevci Rozerin , Hånell Anders , Howells Timothy , Fahlström Andreas , Lewén Anders , Enblad Per , Svedung Wettervik Teodor 
Published: February 2025

OBJECTIVE
There is a paucity of studies on the optimal thresholds for neurointensive care (NIC) targets such as intracranial pressure (ICP) and cerebral perfusion pressure (CPP) in spontaneous intracerebral hemorrhage (sICH). There is also a need to clarify the role of cerebral pressure autoregulatory disturbances (pressure reactivity index [PRx]) and to determine if the autoregulatory CPP target (optimal CPP [CPPopt]) is superior to traditional fixed CPP targets in sICH. In this study, the authors aimed to explore the role of ICP, PRx, CPP, and CPPopt insults in sICH patients treated in the NIC unit.

METHODS
In this observational study, 184 adults with sICH with intracerebral hemorrhage (ICH) volume above 10 ml who received > 12 hours of ICP monitoring during the first 7 days at the authors’ NIC unit, Uppsala University Hospital, Sweden, between 2010 and 2019 (10 years) were included. Demographic characteristics, admission status, radiological examination, and clinical outcome were evaluated. Favorable outcome was defined as conscious at discharge, while unfavorable outcome as unconscious or deceased. ICP, CPP, PRx, and CPPopt during the first 7 days were analyzed in relation to outcome.

RESULTS
In total, 138 (75%) patients recovered favorably at discharge. Lower percentage of good monitoring time with ICP above 25 mm Hg was independently associated with favorable outcome. CPP above 80 mm Hg was frequent and independently associated with favorable outcome. Median PRx did not differ between the outcome groups, but there was a trend toward worse outcome when PRx exceeded +0.5. Furthermore, when PRx was analyzed together with the concurrent ICP and CPP values, higher values increased the ICP and CPP interval associated with unfavorable outcome. Lastly, there was no independent correlation between CPP deviation from CPPopt and outcome.

CONCLUSIONS
Avoiding ICP elevations above 20 to 25 mm Hg and maintaining CPP above 80 mm Hg may be beneficial in sICH patients with large bleeding volume who require NIC. PRx was not independently associated with outcome, but higher values appeared to narrow the safe zones of ICP and CPP.
Carbon fiber–reinforced PEEK implants in oncologic spine surgery: a multicenter experience on implications for postoperative patient management
Authors: Hubertus Vanessa , Wagner Arthur , Albrecht Carolin , Kalasauskas Darius , Jankovic Dragan , Turgut Merih , Lener Sara , Gmeiner Raphael , Miller Hannah , Brüsseler Melanie M. T. , Acker Güliz , Hecht Nils , Onken Julia S. , Combs Stephanie E. , Thomé Claudius , Ringel Florian , Vajkoczy Peter , Meyer Bernhard 
Published: February 2025

OBJECTIVE
Carbon fiber–reinforced polyetheretherketone (CFRP) implants have been used safely in treating spinal oncological disease and promise improved imaging follow-up and radiotherapy planning. However, data on the implant’s routine use in the clinical setting with implications for postoperative management are scarce. The aim of this observational study was to provide real-world insight into the current use of CFRP instrumentations in spinal oncological disease and to define their actual relevance for postoperative imaging follow-up and adjuvant treatment planning.

METHODS
Datasets of patients treated between 2015 and 2022 with CFRP instrumentations due to spinal oncological disease were collected in a multicentric registry at four participating tertiary spine centers in Germany and Austria. Data on each patient’s epidemiology, clinical status, surgery, adjuvant therapy, and outcome was collected retrospectively. Data management was performed using a multicentric REDCap database, and data were reviewed and analyzed descriptively.

RESULTS
A total of 457 patients were enrolled. Most patients received decompression and instrumentation (n = 308 [67%]), with additional cage implantation in 33% (n = 149). In most cases, image-guided navigated screw implantation was performed (n = 321 [70%]). The postoperative complication rate was 13% (n = 61), mostly due to surgical site infections (n = 32 [7%]). Postoperative MRI was performed in 19% (n = 87), with MRI findings prompting revision surgery in 3% (n = 15). In total, 61% of all patients (n = 278) received adjuvant radiotherapy. In those patients, MRI was performed in 6% (18 cases) for procedure planning, while this was mostly based on preinterventional CT (n = 205 [74%]). Of all patients, 27% (n = 124) received routine MRI during follow-up, where relevant local tumor recurrence was detected in 35% (n = 44) at a median follow-up of 6 months.

CONCLUSIONS
Low overall complication and low surgical revision rates were reported. Because of the possibility of higher quality MRI follow-up due to CFRP implants, complications or relevant tumor recurrence during follow-up were detected safely and at a high rate in cases where MRI was performed. However, consequent MRI follow-up was not homogeneously performed, and adjuvant radiotherapy was handled rather heterogeneously. These findings lead to the conclusion that until homogeneous adjuvant follow-up and treatment standards are established, the potential benefits available through the use of CFRP implants are not exhausted, and the decision for the use of CFRP implants in comparison to standard titanium implants remains case-to-case based.
A novel minimally invasive surgical technique for posttraumatic syringomyelia: subarachnoid−subarachnoid bypass
Authors: Yuan Chenghua , Zhang Can , Wang Jiachen , Wu Hao , Chen Zan , Jian Fengzeng , Guan Jian 
Published: February 2025

OBJECTIVE
Current treatment options for posttraumatic syringomyelia (PTS) lack clear standardization and often result in common complications. This study aims to introduce a novel minimally invasive technique for a modified subarachnoid−subarachnoid (S−S) bypass procedure for PTS.

METHODS
The study included 20 consecutive patients with symptomatic PTS who underwent the modified S−S bypass. The surgical technique of modified S−S bypass involved two-laminae fenestration based on preoperative MRI and myelography results showing normal subarachnoid space above and below the injury site. A passer was used to create a subcutaneous tunnel, and two medical-grade silicone tubes were inserted into the normal subarachnoid space at the cranial and caudal ends. Bypass tubes were placed in the subcutaneous tunnel, and dural closure was achieved using 6-0 nonabsorbable sutures. The mean follow-up period was 14.9 (range 12−18) months, with neurological function assessed using a standard grading system and MRI used to evaluate the change in syrinx size.

RESULTS
Seventeen patients demonstrated clinical improvement, while 3 remained stable. The mean preoperative syrinx length on MRI was 16.9 spinal levels, with a mean Syringomyelia Tension Index (STI) of 58.1%. The postoperative mean STI was 28.4%, significantly lower than preoperative values (p < 0.05).

CONCLUSIONS
Modified S−S bypass, which can be performed without myelotomy and without the bypass tubes interfering with the adhesion, was not only a safe and effective surgical technique, but may also be a physiologically better way of treating PTS.