bluuebunny/crossref_metadata_2025_split huggingface dataset:
LESION MIMIC MUTANT 1 confers basal resistance to Sclerotinia sclerotiorum in rapeseed via a salicylic acid-dependent pathway
Authors: Yu Mengna , Fan Yonghai , Li Xiaodong , Chen Xingyu , Yu Shijie , Wei Siyu , Li Shengting , Chang Wei , Qu Cunmin , Li Jiana , Lu Kun 
Published: July 2023

Abstract
Rapeseed (Brassica napus) is a major edible oilseed crop consumed worldwide. However, its yield is seriously affected by infection from the broad-spectrum non-obligate pathogen Sclerotinia sclerotiorum due to a lack of highly resistant germplasm. Here, we identified a Sclerotinia-resistant and light-dependent lesion mimic mutant from an ethyl methanesulfonate-mutagenized population of the rapeseed inbred Zhongshuang 11 (ZS11) named lesion mimic mutant 1 (lmm1). The phenotype of lmm1 is controlled by a single recessive gene, named LESION MIMIC MUTANT 1 (LMM1), which mapped onto chromosome C04 by bulked segregant analysis within a 2.71-Mb interval. Histochemical analysis indicated that H2O2 strongly accumulated and cell death occurred around the lesion mimic spots. Among 877 differentially expressed genes (DEGs) between ZS11 and lmm1 leaves, 188 DEGs were enriched in the defense response, including 95 DEGs involved in systemic acquired resistance, which is consistent with the higher salicylic acid levels in lmm1. Combining bulked segregant analysis and transcriptome analysis, we identified a significantly up-regulated gene, BnaC4.PR2, which encodes β-1,3-glucanase, as the candidate gene for LMM1. Overexpression of BnaC4.PR2 may induce a reactive oxygen species burst to trigger partial cell death and systemic acquired resistance. Our study provides a new genetic resource for S. sclerotiorum resistance as well as new insights into disease resistance breeding in B. napus.
Magnetic frame-dragging correction to the electromagnetic solution of a compact neutron star
Authors: Torres R , Grismayer T , Cruz F , Silva L O 
Published: July 2023

ABSTRACT
Neutron stars are usually modelled as spherical, rotating perfect conductors with a predominant intrinsic dipolar magnetic field anchored to their stellar crust. Due to their compactness, General Relativity corrections must be accounted for in Maxwell’s equations, leading to modified interior and exterior electromagnetic solutions. We present analytical solutions for slowly rotating magnetized neutron stars, taking into account the magnetic frame-dragging correction. For typical compactness values, i.e. Rs ∼ 0.5 [R*], we show that the new terms lead to a per cent order correction in the magnetic field orientation and strength compared to the case, with no magnetic frame-dragging correction. Also, we obtain a self-consistent redistribution of the surface azimuthal current. We verify the validity of the derived solution through two-dimensional particle-in-cell simulations of an isolated neutron star. Defining the azimuthal electric and magnetic field amplitudes during the transient phase as observables, we prove that the magnetic frame-dragging correction reduces the transient wave amplitude, as expected from the analytical solution. We show that simulations are more accurate and stable, when we include all first-order terms. The increased accuracy at lower spatiotemporal resolutions translates into a reduction in simulation runtimes.
Discovery of dipolar chromospheres in two white dwarfs
Authors: Farihi J , Hermes J J , Littlefair S P , Howarth I D , Walters N , Parsons S G 
Published: July 2023

ABSTRACT
This paper reports the ULTRACAM discovery of dipolar surface spots in two cool magnetic white dwarfs with Balmer emission lines, while a third system exhibits a single spot, similar to the prototype GD 356. The light curves are modelled with simple, circular, isothermal dark spots, yielding relatively large regions with minimum angular radii of 20°. For those stars with two light-curve minima, the dual spots are likely observed at high inclination (or colatitude); however, identical and antipodal spots cannot simultaneously reproduce both the distinct minima depths and the phases of the light-curve maxima. The amplitudes of the multiband photometric variability reported here are all several times larger than that observed in the prototype GD 356; nevertheless, all DAHe stars with available data appear to have light-curve amplitudes that increase towards the blue in correlated ratios. This behaviour is consistent with cool spots that produce higher contrasts at shorter wavelengths, with remarkably similar spectral properties given the diversity of magnetic field strengths and rotation rates. These findings support the interpretation that some magnetic white dwarfs generate intrinsic chromospheres as they cool, and that no external source is responsible for the observed temperature inversion. Spectroscopic time-series data for DAHe stars is paramount for further characterization, where it is important to obtain well-sampled data, and consider wavelength shifts, equivalent widths, and spectropolarimetry.
Density and velocity correlations in isothermal supersonic turbulence
Authors: Rabatin Branislav , Collins David C 
Published: July 2023

ABSTRACT
In star-forming clouds, high velocity flow gives rise to large fluctuations of density. In this work, we explore the correlation between velocity magnitude (speed) and density. We develop an analytic formula for the joint probability distribution function (PDF) of density and speed, and discuss its properties. In order to develop an accurate model for the joint PDF, we first develop improved models of the marginalized distributions of density and speed. We confront our results with a suite of 12 supersonic isothermal simulations with resolution of $1024^3$ cells in which the turbulence is driven by 3 different forcing modes (solenoidal, mixed, and compressive) and 4 rms Mach numbers (1, 2, 4, 8). We show, that for transsonic turbulence, density and speed are correlated to a considerable degree and the simple assumption of independence fails to accurately describe their statistics. In the supersonic regime, the correlations tend to weaken with growing Mach number. Our new model of the joint and marginalized PDFs are a factor of 3 better than uncorrelated, and provides insight into this important process.
Heterogeneity in subjective cognitive decline in the Sino Longitudinal Study on Cognitive Decline(SILCODE): Empirically derived subtypes, structural and functional verification
Authors: Fu Zhenrong , Zhao Mingyan , Li Yuxia , He Yirong , Wang Xuetong , Zhou Zongkui , Han Ying , Li Shuyu 
Published: July 2023

AbstractAimsWe evaluated whether Subjective Cognitive Decline (SCD) subtypes could be empirically derived within the Sino Longitudinal Study on Cognitive Decline (SILCODE) SCD cohort and examined associated neuroimaging markers, biomarkers, and clinical outcomes.MethodsA cluster analysis was performed on eight neuropsychological test scores from 124 SCD SILCODE participants and 57 normal control (NC) subjects. Structural and functional neuroimaging indices were used to evaluate the SCD subgroups.ResultsFour subtypes emerged: (1) dysexecutive/mixed SCD (n = 23), (2) neuropsychiatric SCD (n = 24), (3) amnestic SCD (n = 22), and (4) cluster‐derived normal (n = 55) who exhibited normal performance in neuropsychological tests. Compared with the NC group, each subgroup showed distinct patterns in gray matter (GM) volume and the amplitude of low‐frequency fluctuations (ALFF). Lower fractional anisotropy (FA) values were only found in the neuropsychiatric SCD group relative to NC.ConclusionThe identification of empirically derived SCD subtypes demonstrates the presence of heterogeneity in SCD neuropsychological profiles. The cluster‐derived normal group may represent the majority of SCD individuals who do not show progressive cognitive decline; the dysexecutive/mixed SCD and amnestic SCD might represent high‐risk groups with progressing cognitive decline; and finally, the neuropsychiatric SCD may represent a new topic in SCD research.
Adult hemiconvulsive hemiatrophy syndrome: a novel clinicoradiologic disorder in adults
Authors: Kam Ian , Phatouros Constantine , Prentice David , Kho Lay K. , Parizel Paul 
Published: July 2023

AbstractThe association of focal motor seizures with cerebral hemiatrophy is a recognised rare paediatric syndrome known as ‘hemiconvulsion, hemiatrophy and epilepsy’ (HHE). To date, HHE has not been reported in adults. We present four adult patients with striking similarities to HHE, following alcohol withdrawal in chronic alcoholics. We document the imaging findings in the acute and subacute phases, discuss the underlying mechanisms and present a hypothesis regarding the pathophysiology.
Atopic dermatitis and risk of 14 site‐specific cancers: A Mendelian randomization study
Authors: Liu Qiang , Chen Li , Wang Yipeng , Wang Xiangyu , Lewis Sarah J. , Wang Jing 
Published: July 2023

AbstractBackgroundAtopic dermatitis (AD) accounts for a large proportion of the burden of skin disease, with a prevalence of around 10% among adults worldwide. In addition, systematic reviews and meta‐analyses have found that AD is associated with cancer risk at several sites; if found to be causal this could highlight potential treatment targets to reduce cancer risk.ObjectivesTo assess the potential causative link between AD and 14 site‐specific cancers in a two‐sample randomization study.MethodsFrom the largest genome‐wide association study (GWAS) of AD (10,788 cases and 30,047 non‐cases), genetic variants highly associated (p < 5 × 10−8) with AD in the European population were selected as instrumental variables (IVs). Data from large cancer consortia, as well as the UK Biobank study (n = 442,239) and the FinnGen study (n = 218,792), were employed to assess genetic associations with 14 site‐specific cancers and overall cancer. A set of complementary approaches and sensitivity analyses were carried out to examine the robustness of our results. In addition, associations for the same cancer site from different data sources were combined using meta‐analyses.ResultsWe discovered no strong causal evidence of AD on the risk of overall cancer, with effect estimates close to zero. After the Benjamini–Hochberg correction, the inverse‐variance weighted method indicated no association between AD and overall cancer risk in both the UK Biobank (OR, 1.00; 95% CI, 0.94–1.06; FDR, 0.98) and FinnGen studies (OR, 0.96; 95% CI, 0.92–1.02; FDR, 0.68). No strong evidence of an association was found between genetically predicted AD and the risk of any site‐specific cancers.ConclusionsOur MR investigation does not support a causal effect of AD on cancer risk. This finding has important implications for the prevention and management of both AD and cancer, as it reduces the concern of potential adverse effects of AD on cancer outcomes.
Plasma chemistry reference intervals for adult multi‐drug‐resistance gene deficient Collies
Authors: Massat M. Joan , Myles Matthew , DeJong Keith , Ballard Chelsea , Drag Marlene , Malinski Thomas J. 
Published: July 2023

BackgroundDifferences in the reference intervals between dog breeds have been recognized for many years. Due to the importance of multi‐drug‐resistance 1‐deficient (MDR1) Collies in veterinary medicine, it is important to determine whether breed‐specific reference intervals are needed for this group.ObjectivesThe goal of this study was to establish plasma chemistry reference intervals for adult MDR1‐deficient Collies.MethodsPlasma samples collected from 110 healthy male and female adult MDR1‐deficient Collies were analyzed for 21 analytes on a Beckman AU480 clinical chemistry analyzer. Reference intervals were established using a nonparametric statistical method.ResultsReference intervals were established for 21 biochemical measurands in healthy adult MDR1‐deficient Collies.ConclusionPlasma chemistry reference intervals for MDR1‐deficient Collies were clinically similar to intervals earlier created for Beagles. Intervals for male and female MDR1‐deficient Collies were very similar to each other.
Comparison of ultrasound-guided transversalis fascia plane block and anterior quadratus lumborum block in patients undergoing caesarean delivery: a randomized study
Authors: Bilgin Sezgin , Aygun Hakan , Genc Caner , Dost Burhan , Tulgar Serkan , Kaya Cengiz , Sertoz Nezih , Koksal Ersin 
Published: July 2023

AbstractBackgroundCesarean section is becoming increasingly common. Well-managed postoperative analgesia improves patient comfort while encouraging early ambulation and breastfeeding. The analgesic efficacy of transversalis facial plane block (TFPB) vs. anterior quadratus lumborum block (QLB) was compared in this study.MethodsWe analyzed the data of 49 pregnant women (gestation, ≥ 37weeks; age, 18–45years) scheduled for elective cesarean delivery (CD) under general anesthesia. They were randomly divided into TFPB and anterior QLB groups. All blocks were administered bilaterally with 25mL of 0.25% bupivacaine under ultrasound guidance prior to extubation. Postoperative morphine consumption and numerical rating scale (NRS) pain scores (static and dynamic [during coughing]) were recorded at 1, 3, 6, 9, 12, 18, and 24h.ResultsThere was no difference in postoperative morphine consumption between the groups at the third, sixth, and ninth hours, but the anterior QLB group consumed less morphine at the 12th, 18th, and 24th hours. Except for the first hour, resting and dynamic NRS scores were comparable between the groups. The first-hour resting and dynamic NRS scores were lower in the TFPB group (resting NRS, anterior QLB group, median [interquartile range], 2 [2–3] vs. TFPB group, 2 [0–2],p = 0.046; dynamic NRS, anterior QLB group, median [interquartile range], 3 [2–4] vs. TFPB group 2 [0–3],p = 0.001).ConclusionsIn patients undergoing CD, anterior QLB decreased morphine consumption in the late period (9–24h) compared to TFPB, while pain scores were similar between both groups. The reduction in morphine consumption was statistically significant, but not clinically significant.
Prevalence of dyslipidemia and its associated factors among university academic staff and students in Bangladesh
Authors: Ali Nurshad , Kathak Rahanuma Raihanu , Fariha Khandaker Atkia , Taher Abu , Islam Farjana 
Published: July 2023

Abstract
Background
Dyslipidemia is one of the important contributors to cardiovascular disease and type 2 diabetes. There is little or no information on dyslipidemia among academic staff and students in Bangladesh. Therefore, this study aimed to investigate the prevalence and factors related to dyslipidemia among university academic staff and students in Bangladesh.

Methods
A total of 533 participants (302 academic staff and 231 students) were enrolled in this cross-sectional study. A simple random sampling technique was used to enrol the participants. Fasting blood samples were obtained from the participants, and serum levels of triglycerides (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) were measured using the standard methods. Dyslipidemia was defined according to the National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATP-III) model guideline. Multivariable logistic regression was conducted to identify the factors related to lipid marker abnormalities.

Results
Overall, the prevalence of dyslipidemia was 81.5%, of which 85% was in staff and 76.5% in students. A significant difference was found in the prevalence of dyslipidemia between males and females only in the student group (p < 0.01). Among staff, hypertriglyceridemia prevalence was 49.7%, hypercholesterolemia 23%, high LDL-C 24.7% and low HDL-C 77.3%. On the other hand, hypertriglyceridemia prevalence was 39%, hypercholesterolemia 25.6%, high LDL-C 26.5% and low HDL-C 69.3% among students. The most common lipid abnormality was low HDL-C in both groups. The prevalence of mixed dyslipidemia was 14.2% and 14.1% in staff and students, respectively. According to the regression analysis, increased age, obesity, diabetes, and inadequate physical activity were significantly associated with dyslipidemia.

Conclusions
Dyslipidemia was prevalent among the majority of the study participants. Increased age, obesity, diabetes, and inadequate physical activity were significantly associated with dyslipidemia. The study’s results highlight the importance of implementing interventions to address the associated risk factors of dyslipidemia among academic staff and students in Bangladesh.
Identifying self-presentation components among nursing students with unsafe clinical practice: a qualitative study
Authors: Ghasempour Mostafa , Ghahramanian Akram , Zamanzadeh Vahid , Valizadeh Leila , Killam Laura A. , Asghari-Jafarabadi Mohammad , Purabdollah Majid 
Published: July 2023

Abstract
Background
Maintaining patient safety is a practical standard that is a priority in nursing education. One of the main roles of clinical instructors is to evaluate students and identify if students exhibit unsafe clinical practice early to support their remediation. This study was conducted to identify self-presentation components among nursing students with unsafe clinical practice.

Methods
This qualitative study was conducted with 18 faculty members, nursing students, and supervisors of medical centers. Data collection was done through purposive sampling and semi-structured interviews. Data analysis was done using conventional qualitative content analysis using MAXQDA10 software.

Results
One main category labelled self-presentation emerged from the data along with three subcategories of defensive/protective behaviors, assertive behaviors, and aggressive behaviors.

Conclusion
In various clinical situations, students use defensive, assertive, and aggressive tactics to maintain their professional identity and present a positive image of themselves when they make a mistake or predict that they will be evaluated on their performance. Therefore, it seems that the first vital step to preventing unsafe behaviors and reporting medical errors is to create appropriate structures for identification, learning, guidance, and evaluation based on progress and fostering a growth mindset among students and clinical educators.
Identification and analysis of lipid metabolism-related genes in allergic rhinitis
Authors: Tao Qilei , Zhu Yajing , Wang Tianyu , Deng Yue , Liu Huanhai , Wu Jian 
Published: July 2023

Abstract
Background
Studies have shown that the lipid metabolism mediator leukotriene and prostaglandins are associated with the pathogenesis of allergic rhinitis (AR). The aim of this study was to identify key lipid metabolism-related genes (LMRGs) related to the diagnosis and treatment of AR.

Materials and methods
AR-related expression datasets (GSE75011, GSE46171) were downloaded through the Gene Expression Omnibus (GEO) database. First, weighted gene co-expression network analysis (WGCNA) was used to get AR-related genes (ARRGs). Next, between control and AR groups in GSE75011, differentially expressed genes (DEGs) were screened, and DEGs were intersected with LMRGs to obtain lipid metabolism-related differentially expressed genes (LMR DEGs). Protein-protein interaction (PPI) networks were constructed for these LMR DEGs. Hub genes were then identified through stress, radiality, closeness and edge percolated component (EPC) analysis and intersected with the ARRGs to obtain candidate genes. Biomarkers with diagnostic value were screened via receiver operating characteristic (ROC) curves. Differential immune cells screened between control and AR groups were then assessed for correlation with the diagnostic genes, and clinical correlation analysis and enrichment analysis were performed. Finally, real-time fluorescence quantitative polymerase chain reaction (RT-qPCR) was made on blood samples from control and AR patients to validate these identified diagnostic genes.

Results
73 LMR DEGs were obtained, which were involved in biological processes such as metabolism of lipids and lipid biosynthetic processes. 66 ARRGs and 22 hub genes were intersected to obtain four candidate genes. Three diagnostic genes (LPCAT1, SGPP1, SMARCD3) with diagnostic value were screened according to the AUC > 0.7, with markedly variant between control and AR groups. In addition, two immune cells, regulatory T cells (Treg) and T follicular helper cells (TFH), were marked variations between control and AR groups, and SMARCD3 was significantly associated with TFH. Moreover, SMARCD3 was relevant to immune-related pathways, and correlated significantly with clinical characteristics (age and sex). Finally, RT-qPCR results indicated that changes in the expression of LPCAT1 and SMARCD3 between control and AR groups were consistent with the GSE75011 and GSE46171.

Conclusion
LPCAT1, SGPP1 and SMARCD3 might be used as biomarkers for AR.
Musashi Exerts Control of Gonadotrope Target mRNA Translation During the Mouse Estrous Cycle
Authors: Moreira Ana Rita Silva , Lim Juchan , Urbaniak Alicja , Banik Jewel , Bronson Katherine , Lagasse Alex , Hardy Linda , Haney Anessa , Allensworth Melody , Miles Tiffany K , Gies Allen , Byrum Stephanie D , Wilczynska Ania , Boehm Ulrich , Kharas Michael , Lengner Christopher , MacNicol Melanie C , Childs Gwen V , MacNicol Angus M , Odle Angela K 
Published: July 2023

Abstract
The anterior pituitary controls key biological processes, including growth, metabolism, reproduction, and stress responses through distinct cell types that each secrete specific hormones. The anterior pituitary cells show a remarkable level of cell type plasticity that mediates the shifts in hormone-producing cell populations that are required to meet organismal needs. The molecular mechanisms underlying pituitary cell plasticity are not well understood. Recent work has implicated the pituitary stem cell populations and specifically, the mRNA binding proteins of the Musashi family in control of pituitary cell type identity. In this study we have identified the target mRNAs that mediate Musashi function in the adult mouse pituitary and demonstrate the requirement for Musashi function in vivo. Using Musashi RNA immunoprecipitation, we identify a cohort of 1184 mRNAs that show specific Musashi binding. Identified Musashi targets include the Gnrhr mRNA, which encodes the gonadotropin-releasing hormone receptor (GnRHR), and the Fshb mRNA, encoding follicle-stimulating hormone (FSH). Reporter assays reveal that Musashi functions to exert repression of translation of the Fshb mRNA, in addition to the previously observed repression of the Gnrhr mRNA. Importantly, mice engineered to lack Musashi in gonadotropes demonstrate a failure to repress translation of the endogenous Gnrhr and Fshb mRNAs during the estrous cycle and display a significant heterogeneity in litter sizes. The range of identified target mRNAs suggests that, in addition to these key gonadotrope proteins, Musashi may exert broad regulatory control over the pituitary proteome in a cell type–specific manner.