bluuebunny/crossref_metadata_2025_split huggingface dataset:
HiRAM: A hierarchical risk assessment model and its implementation for an industrial Internet of Things in the cloud
Authors: Sun Wen‐Lin , Tang Ying‐Han , Huang Yu‐Lun 
Published: May 2023

AbstractThe trend towards intelligent control processes has introduced the Internet of Things (IoT) and cloud computing technologies to factories. IoT devices can sense data and send it to a cloud for further analysis in a factory. Consequently, the quantity of such valuable data flowing in an industrial cyber‐physical system has gradually increased. Tailoring a risk assessment system for Industrial IoT (IIoT) is essential, particularly for a cloud platform that handles the IIoT data flow. In this study, we leverage analytic hierarchy processes (AHPs) and propose Hierarchical Risk Assessment Model (HiRAM) for an IIoT cloud platform. The proposed model allows the platform to self‐evaluate its security status. Furthermore, a modular and responsive Risk Assessment System based on HiRAM, called HiRAM‐RAS, is realized and evaluated in a real‐world IIoT cloud platform. We deploy HiRAM‐RAS to a sample application and introduce the practical deployment procedures. We then estimate the practicality of the HiRAM‐RAS by injecting different degrees of errors and launching Distributed denial‐of‐service (DDoS) attacks. The results demonstrate the changes in integrity and availability scores evaluated by HiRAM.
Design of earth‐abundant amorphous transition metal‐based catalysts for electrooxidation of small molecules: Advances and perspectives
Authors: Chen Zhijie , Han Ning , Zheng Renji , Ren Zijie , Wei Wei , Ni Bing‐Jie 
Published: May 2023

AbstractElectrochemical oxidation of small molecules (e.g., water, urea, methanol, hydrazine, and glycerol) has gained growing scientific interest in the fields of electrochemical energy conversion/storage and environmental remediation. Designing cost‐effective catalysts for the electrooxidation of small molecules (ESM) is thus crucial for improving reaction efficiency. Recently, earth‐abundant amorphous transition metal (TM)‐based nanomaterials have aroused souring interest owing to their earth‐abundance, flexible structures, and excellent electrochemical activities. Hundreds of amorphous TM‐based nanomaterials have been designed and used as promising ESM catalysts. Herein, recent advances in the design of amorphous TM‐based ESM catalysts are comprehensively reviewed. The features (e.g., large specific surface area, flexible electronic structure, and facile structure reconstruction) of amorphous TM‐based ESM catalysts are first analyzed. Afterward, the design of various TM‐based catalysts with advanced strategies (e.g., nanostructure design, component regulation, heteroatom doping, and heterostructure construction) is fully scrutinized, and the catalysts’ structure‐performance correlation is emphasized. Future perspectives in the development of cost‐effective amorphous TM‐based catalysts are then outlined. This review is expected to provide practical strategies for the design of next‐generation amorphous electrocatalysts.
Open drug discovery in Alzheimer's disease
Authors: Axtman Alison D. , Brennan Paul E. , Frappier‐Brinton Tristan , Betarbet Ranjita , Carter Gregory W. , Fu Haian , Gileadi Opher , Greenwood Anna K. , Leal Karina , Longo Frank M. , Mangravite Lara M. , Edwards Aled M. , Levey Allan I. ,   The Emory‐Sage‐SGC TREAT‐AD Center
Published: May 2023

AbstractAlzheimer's disease (AD) drug discovery has focused on a set of highly studied therapeutic hypotheses, with limited success. The heterogeneous nature of AD processes suggests that a more diverse, systems‐integrated strategy may identify new therapeutic hypotheses. Although many target hypotheses have arisen from systems‐level modeling of human disease, in practice and for many reasons, it has proven challenging to translate them into drug discovery pipelines. First, many hypotheses implicate protein targets and/or biological mechanisms that are under‐studied, meaning there is a paucity of evidence to inform experimental strategies as well as high‐quality reagents to perform them. Second, systems‐level targets are predicted to act in concert, requiring adaptations in how we characterize new drug targets. Here we posit that the development and open distribution of high‐quality experimental reagents and informatic outputs—termed target enabling packages (TEPs)—will catalyze rapid evaluation of emerging systems‐integrated targets in AD by enabling parallel, independent, and unencumbered research.
Sanctorius Sanctorius: Between Koper and Venice
Authors: Hollerbach Teresa 
Published: May 2023

AbstractBy way of introduction, this chapter gives a biographical account of Sanctorius that situates him in his social, institutional, and professional context. The chapter critically evaluates the existing biographies of the Venetian physician and complements them with my own research on the primary sources. Episodes in Sanctorius’s life that have hitherto received little or no attention are discussed in more detail. This opens up a new perspective on the life and work of Sanctorius, setting the stage for the more comprehensive reconsideration of his work to be found in the following chapters.
Orthogonal Polynomials with Periodically Modulated Recurrence Coefficients in the Jordan Block Case II
Authors: Świderski Grzegorz , Trojan Bartosz 
Published: May 2023

AbstractWe study Jacobi matrices with N-periodically modulated recurrence coefficients when the sequence of N-step transfer matrices is convergent to a non-trivial Jordan block. In particular, we describe asymptotic behavior of their generalized eigenvectors, we prove convergence of N-shifted Turán determinants as well as of the Christoffel–Darboux kernel on the diagonal. Finally, by means of subordinacy theory, we identify their absolutely continuous spectrum as well as their essential spectrum. By quantifying the speed of convergence of transfer matrices we were able to cover a large class of Jacobi matrices. In particular, those related to generators of birth–death processes.
Neural networks vs. splines: advances in numerical extruder design
Authors: Lee Jaewook , Hube Sebastian , Elgeti Stefanie 
Published: May 2023

AbstractIn this paper, we present a novel approach to geometry parameterization that we apply to the design of mixing elements for single-screw extruders. The approach uses neural networks of a specific architecture to automatically learn an appropriate parameterization. This stands in contrast to the so far common user-defined parameterizations. Geometry parameterization is crucial in enabling efficient shape optimization as it allows for optimizing complex shapes using only a few design variables. Recent approaches often utilize computer-aided design (CAD) data in conjunction with spline-based methods where the spline’s control points serve as design variables. Consequently, these approaches rely on the design variables specified by the human designer. This approach results in a significant amount of manual tuning to define a suitable parameterization. In addition, despite this effort, many times the optimization space is often limited to shapes in close proximity to the initial shape. In particular, topological changes are usually not feasible. In this work, we propose a method that circumvents this dilemma by providing low-dimensional, yet flexible shape parametrization using a neural network, which is independent of any computational mesh or analysis methods. Using the neural network for the geometry parameterization extends state-of-the-art methods in that the resulting design space is not restricted to user-prescribed modifications of certain basis shapes. Instead, within the same optimization space, we can interpolate between and explore seemingly unrelated designs. To show the performance of this new approach, we integrate the developed shape parameterization into our numerical design framework for dynamic mixing elements in plastics’ extrusion. Finally, we challenge the novel method in a competitive setting against current free-form deformation-based approaches and demonstrate the method’s performance even at this early stage.
Tumour-stroma ratio (TSR) in breast cancer: comparison of scoring core biopsies versus resection specimens
Authors: Karancsi Zsófia , Hagenaars Sophie C. , Németh Kristóf , Mesker Wilma E. , Tőkés Anna Mária , Kulka Janina 
Published: May 2023

Abstract
Purpose
Tumour-stroma ratio (TSR) is an important prognostic and predictive factor in several tumour types. The aim of this study is to determine whether TSR evaluated in breast cancer core biopsies is representative of the whole tumour.

Method
Different TSR scoring methods, their reproducibility, and the association of TSR with clinicopathological characteristics were investigated in 178 breast carcinoma core biopsies and corresponding resection specimens. TSR was assessed by two trained scientists on the most representative H&E-stained digitised slides. Patients were treated primarily with surgery between 2010 and 2021 at Semmelweis University, Budapest.

Results
Ninety-one percent of the tumours were hormone receptor (HR)-positive (luminal-like). Interobserver agreement was highest using 100 × magnification (κcore = 0.906, κresection specimen = 0.882). The agreement between TSR of core biopsies and resection specimens of the same patients was moderate (κ = 0.514). Differences between the two types of samples were most frequent in cases with TSR scores close to the 50% cut-off point. TSR was strongly correlated with age at diagnosis, pT category, histological type, histological grade, and surrogate molecular subtype. A tendency was identified for more recurrences among stroma-high (SH) tumours (p = 0.07). Significant correlation was detected between the TSR and tumour recurrence in grade 1 HR-positive breast cancer cases (p = 0.03).

Conclusions
TSR is easy to determine and reproducible on both core biopsies and in resection specimens and is associated with several clinicopathological characteristics of breast cancer. TSR scored on core biopsies is moderately representative for the whole tumour.
Favorable survival outcomes in epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer sequentially treated with a tyrosine kinase inhibitor and osimertinib in a real-world setting
Authors: Kraskowski Oliver , Stratmann Jan A. , Wiesweg Marcel , Eberhardt Wilfried , Metzenmacher Martin , Schmid Kurt W. , Herold Thomas , Schildhaus Hans-Ulrich , Darwiche Kaid , Aigner Clemens , Stuschke Martin , Laue Katharina , Zaun Gregor , Kasper Stefan , Hense Jörg , Sebastian Martin , Schuler Martin , Pogorzelski Michael 
Published: May 2023

Abstract
Purpose
EGFR tyrosine kinase inhibitor (TKI) therapy in EGFR-mutated lung cancer is limited by acquired resistance. In half of the patients treated with first/second-generation (1st/2nd gen) TKI, resistance is associated with EGFR p.T790M mutation. Sequential treatment with osimertinib is highly active in such patients. Currently, there is no approved targeted second-line option for patients receiving first-line osimertinib, which thus may not be the best choice for all patients. The present study aimed to evaluate the feasibility and efficacy of a sequential TKI treatment with 1st/2nd gen TKI, followed by osimertinib in a real-world setting.

Methods
Patients with EGFR-mutated lung cancer treated at two major comprehensive cancer centers were retrospectively analyzed by the Kaplan–Meier method and log rank test.

Results
A cohort of 150 patients, of which 133 received first-line treatment with a first/second gen EGFR TKI, and 17 received first-line osimertinib, was included. Median age was 63.9 years, 55% had ECOG performance score of ≥ 1. First-line osimertinib was associated with prolonged progression-free survival (P = 0.038). Since the approval of osimertinib (February 2016), 91 patients were under treatment with a 1st/2nd gen TKI. Median overall survival (OS) of this cohort was 39.3 months. At data cutoff, 87% had progressed. Of those, 92% underwent new biomarker analyses, revealing EGFR p.T790M in 51%. Overall, 91% of progressing patients received second-line therapy, which was osimertinib in 46%. Median OS with sequenced osimertinib was 50 months. Median OS of patients with p.T790M-negative progression was 23.4 months.

Conclusion
Real-world survival outcomes of patients with EGFR-mutated lung cancer may be superior with a sequenced TKI strategy. Predictors of p.T790M-associated resistance are needed to personalize first-line treatment decisions.
Transitions across states with and without difficulties in performing activities of daily living and death: a longitudinal comparison of ten European countries
Authors: Marroig Alejandra 
Published: May 2023

AbstractAgeing has been related to the onset of disability and dependency in older adults. There is a need to better understand the disability and dependency trajectories of older adults and their relationship with socio-demographic characteristics and institutional or cultural context. This study analyses the role of age, sex, education and self-perceived health in disability, dependency and death transitions, addressing the heterogeneity across European countries and inconsistencies when using different measures of disability. Multi-state models were adjusted to evaluate the role of risk and protective factors in the transitions to disability, dependency and death. Difficulties in performing activities of daily living (ADLs) assess disability and dependency states. Data were from the Survey of Health, Ageing and Retirement in Europe conducted in 2004–2013, considering individuals aged 65 and older at baseline from Austria, Belgium, Denmark, France, Germany, Italy, the Netherlands, Spain, Sweden and Switzerland. The results showed that transitions to disability and dependency varied with age, sex, education and self-perceived health. The probability of transition to disability and dependency states increases until the age of 70 for all countries. However, there was heterogeneity in the disability and dependency trajectories with ageing between men and women. In most countries, women live with difficulties and may need help for longer than men. Care policies should consider sex differences to decrease the burden of care of informal caregivers, particularly in countries where care systems are absent or partially developed and a high level of family obligations to care needs exist.
Complications in Patients Undergoing Laparoscopic Bariatric Surgery in an ERABS-optimized, High-Volume, Single Center During 2020 and 2021
Authors: Stryhn Katrine , Alstrup Lærke , Riber Claus , Ørting Michael , Hadad Rakin , Hvistendahl Jan , Tollund Carsten , Boye Niels , Haugaard Steen B. , Funch-Jensen Peter 
Published: May 2023

Abstract

Purpose

Complication rates after fast-track optimization in bariatric surgery are varying. The aim of this study was to identify short-term complications in patients undergoing laparoscopic sleeve gastrectomy (SG) in an ERABS (enhanced recovery after bariatric surgery) optimized setup.

Materials and Methods
This study is an observational analysis of a consecutive cohort of 1600 patients undergoing SG at an ERABS-optimized, private hospital during 2020 and 2021. Primary outcomes were length of stay, mortality, readmissions, reoperations, and complications according to the Clavien-Dindo classification (CDC) within postoperative day (POD) 30 and 90. Secondary outcomes were weight loss and quality of life (QoL) according to Moorehead-Ardelt questionnaires during the first postoperative year.

Results
Primary outcomes: 99.1% of patients were discharged within POD 1. The 90-day mortality rate was zero. There were 1% readmissions and 1.2% reoperations within POD 30. Total 30-day complication rate was 4.6%, where 3.4% accounted for CDC grades ≤ II, and 1.3% accounted for CDC grade III. There were zero grade IV–V complications. Secondary outcomes: One year after surgery, weight loss was substantial (p < 0.001), with an excess weight loss of 71.9%, and QoL had significantly increased (p < 0.001).

Conclusion
This study demonstrates that the use of an ERABS protocol in bariatric surgery does not compromise neither safety nor efficacy. Complication rates were low, and weight loss was significant. This study thus provides strong arguments that ERABS programs are beneficial in bariatric surgery.

Graphical Abstract
Putting small fish on the table: the underutilized potential of small indigenous fish to improve food and nutrition security in East Africa
Authors: Wessels Laura , Kjellevold Marian , Kolding Jeppe , Odoli Cyprian , Aakre Inger , Reich Felix , Pucher Johannes 
Published: May 2023

AbstractSub-Saharan Africa has a high prevalence of food insecurity. Small pelagic fish such as Silver cyprinid (Rastrineobola argentea) which is indigenous to Lake Victoria, can be a nutritious animal sourced food that contributes to a more nutrient dense diet. Potential sustainable catch of Silver cyprinid is estimated at 2 million tonnes yearly, which is four times the amount of the current catch. Whole sun-dried Silver cyprinid was purchased from several markets in Kenya and analysed for nutrient composition, microbial counts and metal content. The results show that utilizing the whole potential catch of Silver cyprinid would provide a significant daily source of vitamin B12, calcium, zinc and iron to the roughly 33 million people living in the Lake Victoria basin. Heavy metal concentration appears to be low, but other food safety aspects like microbial counts call for value chain improvements. We conclude that the underutilized potential of sun-dried Silver cyprinid could substantially contribute to fight malnutrition and food insecurity by providing an affordable nutrient dense animal sourced food to a large number of people. It also highlights the need to improve the value chains to increase the safety of these products.
Are Socially Relevant Scenes Abnormally Processed in Complex Trauma-Exposed Children?
Authors: Bertó Clara , Almansa-Tomás Belén , Ferrín Maite , Livianos Lorenzo , Rojo Luis , Barberá María , García-Blanco Ana 
Published: May 2023

Abstract
Abnormal attentional processes to socially relevant information may underlie behavioral dysfunctional symptoms in children exposed to a complex trauma. Attentional biases to social scenes close to real-world situations and their association with behavioral symptomatology were examined in complex trauma-exposed children. A visual dot-probe task involving neutral versus emotional (i.e., threatening, sad, or happy) scenes was applied to twenty-one maltreated children (mean age 10.43; 42.8% female; 61.1% White). These children were exposed to a complex trauma (i.e., severe, repeated, multiple, prolonged, and interpersonal) and were safeguarded in a juvenile welfare home after all parental responsibility was removed. Twenty-four comparable non-maltreated children (mean age 10.13; 29.2% female; 76% White), served as control group. All participants were at risk of social exclusion and every legal representative completed the Child Behavior Checklist (CBCL). Complex trauma-exposed children showed an attentional bias toward threatening scenes, while the control group showed an attentional bias toward sad scenes. There were no differences for happy scenes between groups. Attentional bias toward threatening scenes was associated with withdrawn symptoms in complex trauma-exposed children. Children exposed to a complex trauma show an abnormal attention to threatening social situations, which can trigger maladaptive behaviors such as withdrawn. The understanding of how complex trauma-exposed children process affective environmental information may provide new targets in the social skills interventions such as diminishing maladaptive behaviors and improving coping strategies to face threatening situations.
Novel strategy of senescence elimination via toxicity-exempted kinome perturbations by nanoliposome-based thermosensitive hydrogel for osteoarthritis therapy
Authors: Wan Junlai , He Zhiyi , Zhao Yingchao , Hao Xiaoxia , Cui Jiarui , Chen Anmin , Zhou Jun , Zhang Jiaming 
Published: May 2023

AbstractCellular senescence and the senescence-associated secretory phenotype (SASP) have been implicated in osteoarthritis (OA). This study aims to determine whether multi-kinase inhibitor YKL-05-099 (Y099) has potential in senescence elimination and OA therapy and whether delivering Y099 by nanoliposmal hydrogel improves the performance of the kinase inhibitor. Y099 inhibited IL-1β-induced inflammation and catabolism and promoted anabolism of chondrocytes. To attenuate the inhibition of cell viability, nanoliposomal Y099-loaded thermosensitive hydrogel (Y099-Lip-Gel) was developed for sustained release and toxicity exemption. Notably, Y099-Lip-Gel exhibited a pronounced effect on promoting anabolism and suppressing catabolism and inflammation without causing the inhibition of chondrocyte viability. Moreover, Y099-Lip-Gel remarkably increased the master regulator of chondrocyte phenotype Sox9 expression. After four intra-articular injections of Y099-Lip-Gel in the OA murine model, the histological lesions of cartilage were attenuated by Y099-Lip-Gel with subchondral bone loss and osteoclast formation inhibited. Transcriptomic analysis and experimental validations revealed that Y099-Lip-Gel suppressed cellular senescence by inhibiting the expression of senescence inducers and SASP factors. Furthermore, the phosphoproteomic analysis showed that Y099-Lip-Gel exerted a significant influence on kinome phosphorylation, inhibiting the MAPK and NF-κB signaling activations. The protective effects of Y099-Lip-Gel were also validated in cultured human OA cartilage explants. In conclusion, nanoliposomal Y099-loaded thermosensitive hydrogel has considerable potential in OA therapy. Nanoliposome-based hydrogel system has strength in reducing kinase inhibition-induced cytotoxicity, enhancing cellular tolerance to kinome perturbation, and improving the performance of protein kinase inhibitors. Senescence elimination via toxicity-exempted kinome perturbations achieved by advanced nanotechnology is a promising strategy for OA.
Graphical Abstract
Chemical looping: a technology platform for upcycling low-grade industrial resources
Authors: Singh Varun , Buelens Lukas C. , Poelman Hilde , Marin Guy B. , Galvita Vladimir V. 
Published: May 2023

AbstractAmbitions towards a circular economy are increasingly vocalised across academia, policymaking and industry. The endeavour of realising these ambitions provides major opportunities and challenges in chemical engineering, and requires a tremendous roll-out of new technologies. This perspective highlights the suitability of chemical looping as a technology platform to contribute to the valorisation of material streams that are currently not used to their full potential, termed low-grade resources. Such material streams offer significant opportunities to minimise CO2 emissions and accelerate towards a circular materials economy. Apart from defining and identifying low-grade streams, both calorific and non-calorific, a non-exhaustive overview of such streams is provided. Based on a selection of case studies focusing on steel mill gases, bauxite residue, pyrite cinder, calcium carbide slag and automotive shredder residue, it is posited that the characteristics and flexibility of the chemical looping approach offer ample possibilities to efficiently reuse low-grade streams and minimise their environmental impact. Finally, an outlook on chemical looping as a technology platform and its possible role in the drive towards circularity is given, with attention for the roles of industrial, academic and governmental stakeholders. In order to assess the suitability of a chemical looping process for valorising low-grade resources, the importance of holistic technology investigations is stressed, taking into account technical, economic, ecological and societal considerations.