bluuebunny/crossref_metadata_2025_split huggingface dataset:
CMAS degradation of ytterbium aluminum garnets
Authors: Kitaoka Satoshi , Tanaka Makoto , Kawashima Naoki , Ito Taishi , Yokoe Daisaku , Kato Takeharu , Ogawa Takafumi , Yamazaki Naoki , Hosoya Nagisa , Nakamura Takeshi 
Published: March 2023

AbstractThe degradation of ytterbium aluminum garnet (YbAG) exposed to molten Ca–Mg–Fe–Al–Si–O (CMAS) at 1673 K was investigated for two kinds of dense polycrystalline YbAG with compositions deviating slightly from stoichiometry, referred to as Al‐ and Yb‐rich. The mitigation of the CMAS attack for Yb‐rich YbAG was markedly superior to that for the Al‐rich one. For both types of YbAG, corrosion progressed due to the preferential penetration of the CMAS melt along grain boundaries in the thickness direction and the simultaneous dissolution of crystal grains into the melt. The lower of the corroded region consisted of YbAG crystals with a core/shell‐I/shell‐II structure. Shell‐I contained alkaline earth, silicon, and iron cations, whereas these cations were hardly detected in shell‐II. Growth of the shell‐I region was considered to progress by dissolution and reprecipitation through the melt existing around it, and finally, the melt disappeared, resulting in the formation of a thin shell‐II region containing little of these ions. The formation and growth of the shell‐I region were found to be promoted by making the YbAG Yb‐rich, resulting in enhancement of the resistance to CMAS.
Validation of the Parental Understanding and Misperceptions about BAby's Sleep Questionnaire using auto‐videosomnography
Authors: Jang Eunyeong , Kang Solbi , Bei Bei , Chung Seockhoon , Gradisar Michael , Kahn Michal , Barnett Natalie , Suh Sooyeon 
Published: March 2023

BackgroundPrevious studies have suggested that parental cognitions about child's sleep may be an important factor underlying pediatric sleep problems. The current study aimed to (a) develop an assessment tool measuring parental understanding and misperceptions about baby's sleep (PUMBA‐Q); (b) validate the questionnaire using self‐report and objective sleep measures.MethodsThere were 1,420 English‐speaking caregivers (68.0% mothers, 46.8% of children being females, mean age 12.3 months), who has completed online self‐reported questionnaires. The PUMBA‐Q, which was developed for this study, Dysfunctional Beliefs and Attitudes about Sleep (DBAS) and Maternal Cognitions about Infant Sleep Questionnaire (MCISQ) were included to evaluate participant's thoughts on their own or child's sleep. Insomnia Severity Index (ISI) was collected to access participant's subjective insomnia severity. Brief Infant Sleep Questionnaire‐Revised (BISQ‐R) was used to assess parental‐reported child sleep. Auto‐videosomnography was used to record child's sleep.ResultsExploratory factor analysis indicated the best fit with a 4‐factor model using 23 items (RMSEA = .039). The four subscales were labeled: (a) Misperceptions about parental intervention; (b) Misperceptions about feeding; (c) Misperceptions about child's sleep; and (d) General anxiety of parents. Internal consistency was adequate (Cronbach's alpha = .86). PUMBA‐Q scores were significantly associated with MCISQ (r = .64, p < .01), DBAS (r = .36, p < .01), ISI (r = .29, p < .01), BISQ‐R (r = .‐49, p < .01), objective child's total sleep time (r = −.24, p < .01) and objective number of parental nighttime visits (r = .26, p < .01).ConclusionsThe results demonstrated that PUMBA‐Q 23 is a valid assessment tool for parental cognitions of child sleep. The link between parental cognitions and child sleep highlights the importance of managing parental cognitions about child sleep when treating pediatric sleep problems.
Nasal capsule ossification: A histological study using human foetuses to find an association between the foetus and adult morphologies of the nasal wall
Authors: Yamamoto Masahito , Hayashi Shogo , Honkura Yohei , Hirano‐Kawamoto Ai , Katori Yukio , Murakami Gen , Rodríguez‐Vázquez José Francisco , Abe Shinichi 
Published: March 2023

AbstractRecent molecular biology studies have revealed the process of nasal capsule determination. We aimed to create a fate map showing the association between the adult and embryonic components of the nasal wall and nasal capsule derivatives. We examined paraffin‐embedded histological sections between 15 mid‐term (9–16 weeks) and 12 near‐term (27–40 weeks) foetuses. Until 15 weeks, membranous ossification occurred ‘along’ the capsular cartilage, contributing to the formation of the vomer, maxilla and bony nasal septum as well as the nasal, frontal and lacrimal bones. After 15 weeks, a wide lateral part of the capsule became thin and fragmented, and degenerative cartilage was observed near the lacrimal bone, in the three conchae, and at the inferolateral end of the capsule sandwiched between the maxilla and palatine bone. The disappearing cartilages appeared to be replaced by nearby membranous bones. This type of membranous ossification did not appear to use the capsular cartilage as a ‘mould’, although the perichondrium may have a role in inducing ossification. Calcified cartilage indicated endochondral ossification in the inferior concha until 15 weeks and, later, at the bases of three conchae and around the future sphenoid sinus (i.e. the concha sphenoidalis). The capsular cartilage extended antero‐superiorly over the frontal bone and inserted into the nasal bone. At 40 weeks, the capsular cartilage remained in the cribriform plate and at the inferolateral end along the palatine bone. Consequently, less guidance from the nasal capsule seemed to provide great individual variation in the shape of the wide anterolateral wall of the nasal cavity.
A review of the use of beeswax in skincare
Authors: Nong Yvonne , Maloh Jessica , Natarelli Nicole , Gunt Hemali B. , Tristani Esther , Sivamani Raja K. 
Published: March 2023

AbstractBackgroundBeeswax is a naturally occurring product secreted from worker bees that has varied uses in modern day. In skincare, its function ranges from its role as an occlusive, helping to create a semi‐occlusive skin barrier that minimizes transepidermal water loss; as a humectant, locking in hydration; and an emollient to soften and soothe the skin. As a natural substance, its use has been shown to help alleviate symptoms associated with common cutaneous conditions like dermatitis, psoriasis, and overgrowth of normal skin flora.AimsIn this narrative review, we aim to describe current uses of beeswax in skincare that has been published in the literature.Materials and methodsA review of beeswax related publications was performed by searching the PubMed database studies.ResultsA total of five clinical studies were included with three studies on animals and two studies in humans.DiscussionSeveral studies show the benefits of topical beeswax in supporting the skin barrier.ConclusionBeeswax can be a low‐cost, natural ingredient for use in products. Further studies with topical beeswax are warranted.
Does defending affect adolescents' peer status, or vice versa? Testing the moderating effects of empathy, gender, and anti‐bullying norms
Authors: Laninga‐Wijnen Lydia , Malamut Sarah T. , Garandeau Claire F. , Salmivalli Christina 
Published: March 2023

AbstractThis study examined bidirectional associations between students' bully‐directed defending behavior and their peer status (being liked or popular) and tested for the moderating role of empathy, gender, and classroom anti‐bullying norms. Three waves of data were collected at 4–5‐month time intervals among 3680 Finnish adolescents (Mage = 13.94, 53.0% girls). Cross‐lagged panel analyses showed that defending positively predicted popularity and, to a larger degree, being liked over time. No moderating effect of empathy was found. Popularity was more strongly predictive of defending, and defending was more strongly predictive of status among girls than among boys. Moreover, the positive effects of both types of status on defending were—albeit to a limited extent—stronger in classrooms with higher anti‐bullying norms.
Demographic fluctuations and selection during host–parasite co‐evolution interactively increase genetic diversity
Authors: Le Pennec Guénolé , Retel Cas , Kowallik Vienna , Becks Lutz , Feulner Philine G. D. 
Published: March 2023

AbstractHost–parasite interactions can cause strong demographic fluctuations accompanied by selective sweeps of resistance/infectivity alleles. Both demographic bottlenecks and frequent sweeps are expected to reduce the amount of segregating genetic variation and therefore might constrain adaptation during co‐evolution. Recent studies, however, suggest that the interaction of demographic and selective processes is a key component of co‐evolutionary dynamics and may rather positively affect levels of genetic diversity available for adaptation. Here, we provide direct experimental testing of this hypothesis by disentangling the effects of demography, selection and their interaction in an experimental host–parasite system. We grew 12 populations of a unicellular, asexually reproducing algae (Chlorella variabilis) that experienced either growth followed by constant population sizes (three populations), demographic fluctuations (three populations), selection induced by exposure to a virus (three populations), or demographic fluctuations together with virus‐induced selection (three populations). After 50 days (~50 generations), we conducted whole‐genome sequencing of each algal host population. We observed more genetic diversity in populations that jointly experienced selection and demographic fluctuations than in populations where these processes were experimentally separated. In addition, in those three populations that jointly experienced selection and demographic fluctuations, experimentally measured diversity exceeds expected values of diversity that account for the cultures' population sizes. Our results suggest that eco‐evolutionary feedbacks can positively affect genetic diversity and provide the necessary empirical measures to guide further improvements of theoretical models of adaptation during host–parasite co‐evolution.
Latent class analysis of grief‐related beliefs among recently bereaved adults
Authors: Xu Xin , Zou Xinyan , Tang Renzhihui , Jiao Keyuan , Qian Wenli , Shen Xinlan , Wang Jianping , Skritskaya Natalia A. 
Published: March 2023

Grief‐related beliefs play an important role in bereavement adjustment. This study aimed to investigate the patterns and correlates of grief‐related beliefs among recently bereaved adults (n = 311). Latent class analysis results suggested three meaningful grief belief classes could be identified: the High grief belief class (24.1%), Predominantly counterfactual thoughts class (42.4%), and Low belief class (33.4%). Members in the High grief belief class reported the highest levels of grief symptoms, depression and PTSD symptoms, loneliness, and functional impairment. Compared with the Low belief class, unmarried people, people in poor health, individuals who lost parents, partners, or children, and those who experienced violent or unexpected death were more likely to belong to the High grief belief class. Findings of this study support the importance of examining grief‐related cognitions in research and clinical practice, especially counterfactual thoughts about the death, which may need to be specifically screened and targeted in treatment.
Supplemental Material: Generating large volumes of crust-derived high δ<sup>18</sup>O rhyolites in the Chon Aike Silicic Large Igneous Province, Patagonia
Authors: Foley Michelle L. , al. et 
Published: March 2023

<p>Includes data tables of bulk-rock geochemistry, oxygen isotope values by laser fluorination and secondary ion mass spectrometry, and thermodynamic model parameters. Figures of in situ oxygen isotope analyses overlain on quartz cathodoluminescence images. Figures of additional major and trace-element bulk geochemistry plots and SIMS oxygen isotope values plotted per sample. </p>
Effect of Disorder on Magnetotransport in Semiconductor Artificial Graphene
Authors: Tkachenko O. A. , Tkachenko V. A. , Baksheev D. G. , Sushkov O. P. 
Published: March 2023

Magnetotransport in mesoscopic samples with semiconductor artificial graphene has been simulated within the Landauer–Büttiker formalism. Model four-terminal systems in a high-mobility two-dimensional electron gas have a square shape with a side of 3–5 μm, which is filled with a short-period (120 nm) weakly disordered triangular lattice of antidots at the modulation amplitude of the electrostatic potential comparable with the Fermi energy. It has been found that the Hall resistance $${{R}_{{xy}}}(B)$$ in the magnetic field range of B = 10–50 mT has a hole plateau $${{R}_{{xy}}} = - {{R}_{0}}$$, where R0 = h/2e2 = 12.9 kΩ, at carrier densities in the lattice below the Dirac point n < n1D and an electron plateau $${{R}_{{xy}}} = {{R}_{0}}$$ at n > n1D. Enhanced disorder destroys the plateaus, but a carrier type (electrons or holes) holds. Long-range disorder at low magnetic fields suppresses quantized resistance plateaus much more efficiently than short-range disorder.
Data Supplement from Trim32 Facilitates Degradation of MYCN on Spindle Poles and Induces Asymmetric Cell Division in Human Neuroblastoma Cells
Authors: Izumi Hideki , Kaneko Yasuhiko 
Published: March 2023

<p>Supplementary Figure S6. Evaluation of different doses Cdk1/ Cyclin B inhibitor (RO-3306) treatment in neuroblastoma cells. Cells (SK-N-DZ) were treated with 50ng/ml of nocodazole (Noc) with or without low or high concentration (5μM or 10μM) of RO-3306 for 3h. The treated samples were then subjected to immunoblot analysis. RO-3306 treatment reduced Cyclin B and phospho-histone H3 (a mitosis marker) levels in a dose dependent manner as reported previously (1). 1.	Vassilev LT, Tovar C, Chen S, Knezevic D, Zhao X, Sun H, et al. Selective small-molecule inhibitor reveals critical mitotic functions of human CDK1. Proceedings of the National Academy of Sciences of the United States of America. 2006;103:10660-5.</p>
Supplementary Data from A Novel l-Asparaginase with low l-Glutaminase Coactivity Is Highly Efficacious against Both T- and B-cell Acute Lymphoblastic Leukemias <i>In Vivo</i>
Authors: Nguyen Hien Anh , Su Ying , Zhang Jenny Y. , Antanasijevic Aleksandar , Caffrey Michael , Schalk Amanda M. , Liu Li , Rondelli Damiano , Oh Annie , Mahmud Dolores L. , Bosland Maarten C. , Kajdacsy-Balla Andre , Peirs Sofie , Lammens Tim , Mondelaers Veerle , De Moerloose Barbara , Goossens Steven , Schlicht Michael J. , Kabirov Kasim K. , Lyubimov Alexander V. , Merrill Bradley J. , Saunthararajah Yogen , Van Vlierberghe Pieter , Lavie Arnon 
Published: March 2023

<p>Supplementary methods Supplementary Text: Wolinella succinogenes as a low L-glutaminase L-asparaginase Supplementary Figures: â€¢	Fig. S1. In vivo imaging showing that the L-glutaminase-diminished ErA-63Q and ErA-DM variants eliminate T-ALL LOUCY cells as effectively as the high L-glutaminase ErA-WT. â€¢	Fig. S2: In vivo imaging showing that the low L-glutaminase ErA-DM variant eliminates B-ALL SUP-B15 cells as effectively as the high L-glutaminase ErA-WT. â€¢	Fig. S3. In vivo imaging showing that the ultra-low L-glutaminase ErA-TM variant eliminates T-ALL LOUCY cells as effectively as the high L-glutaminase ErA-WT. â€¢	Fig. S4. In vitro sensitivity of two human ALL cell lines to L-asparaginases. â€¢	Fig. S5: Calibration between the in vivo imaging flux intensity and the measured %huCD45+ levels in peripheral blood (PB). â€¢	Fig. S6. In vivo imaging with signal-to-color range adjusted. â€¢	Fig. S7. Correlation between L-glutaminase activity and the reduction in mice activity. â€¢	Fig. S8. Correlation between L-glutaminase activity of the ErA variants and mice weight loss. â€¢	Fig. S9. ASNS qPCR data for the LOUCY cell line and 5 ALL patient samples. Data. Biostatistics on BLI and weight data.</p>
Supplemental Tables S1-S19. from Small-Molecule Activators of Protein Phosphatase 2A for the Treatment of Castration-Resistant Prostate Cancer
Authors: McClinch Kimberly , Avelar Rita A. , Callejas David , Izadmehr Sudeh , Wiredja Danica , Perl Abbey , Sangodkar Jaya , Kastrinsky David B. , Schlatzer Daniela , Cooper Maxwell , Kiselar Janna , Stachnik Agnes , Yao Shen , Hoon Divya , McQuaid Daniel , Zaware Nilesh , Gong Yixuan , Brautigan David L. , Plymate Stephen R. , Sprenger Cynthia C.T. , Oh William K. , Levine Alice C. , Kirschenbaum Alexander , Sfakianos John P. , Sears Rosalie , DiFeo Analisa , Ioannou Yiannis , Ohlmeyer Michael , Narla Goutham , Galsky Matthew D. 
Published: March 2023

<p>Table S1.	KSEA Analysis and the Mean FC Method in LNCaP treated with SMAP. Table S2.	ANOVA with multiple comparisons and Dunnett''s post-hoc test for SMAP treated LNCaP colony formation assay. Table S3.	ANOVA with multiple comparisons and Dunnett''s post-hoc test for SMAP treated 22Rv1 colony formation assay. Table S4.	ANOVA with multiple comparisons and Dunnett''s post-hoc test for Annexin V staining of LNCap and 22Rv1 cells. Table S5.	PPI of the phosphoproteomics dataset. Table S6.	Kinase Substrate Database for LNCaP treated with SMAP. Table S7.	ANOVA with multiple comparisons and Tukey''s post-hoc test for SMAP treatment in LNCaP cells phosphorylated to total AR ratio protein. Table S8.	ANOVA for qRT-PCR RNA for AR targets in LNCaP and 22Rv1 cells in presence of SMAPs. Table S9.	ANOVA with multiple comparisons and Dunnett''s post-hoc test for LNCaP and 22Rv1 cells treated with SMAP, bortezomib, and combination. Table S10. ANOVA with multiple comparisons and Tukey''s post-hoc test for relative AR protein expression in LNCaP- Small T stably expressing lines treated with SMAP. Table S11. ANOVA with multiple comparisons and Tukey''s post-hoc test for relative AR protein expression in LNCaP cells in FBS or CSS in presence or absence of R1881. Table S12. ANOVA for qRT-PCR RNA AR targets statistical analysis for LNCaP cells in FBS or CSS in presence or absence of R1881. Table S13. ANOVA with multiple comparisons and Dunnett''s post-hoc test for LnCaP/AR xenograft treatment study: vehicle control, SMAP 400mg/kg, SMAP 100mg/kg and MDV3100 100mg/kg. Table S14. ANOVA with multiple comparisons and Dunnett''s post-hoc test for castrated LNCaP/AR tumor volumes for individual treatments groups: Vehicle control, SMAP-2 100mg/kg and SMAP-2 30mg/kg. Table S15. ANOVA with multiple comparisons and Dunnett''s post-hoc test for TUNEL positive staining quantification from castrated LNCaP/AR tumors from individual treatments groups: Vehicle control, SMAP-2 30mg/kg and SMAP-2 100mg/kg. Table S16. ANOVA with multiple comparisons and Dunnett''s post-hoc test for PCNA positive staining quantification from castrated LNCaP/AR for individual treatments groups: Vehicle control, SMAP-2 100mg/kg and SMAP-2 30mg/kg.</p>
Supplementary MovieS2a from Immunotherapeutic Targeting and PET Imaging of DLL3 in Small-Cell Neuroendocrine Prostate Cancer
Authors: Chou Jonathan , Egusa Emily A. , Wang Sinan , Badura Michelle L. , Lee Fei , Bidkar Anil P. , Zhu Jun , Shenoy Tanushree , Trepka Kai , Robinson Troy M. , Steri Veronica , Huang Jiaoti , Wang Yuzhuo , Small Eric J. , Chan Emily , Stohr Bradley A. , Ashworth Alan , Delafontaine Brant , Rottey Sylvie , Cooke Keegan S. , Hashemi Sadraei Nooshin , Yu Brian , Salvati Mark , Bailis Julie M. , Feng Felix Y. , Flavell Robert R. , Aggarwal Rahul 
Published: March 2023

<p>Supplemental Movies 2a-2c: 22Rv1-NuclightGreen and SHP-77-NuclightRed mixed population co-cultures. Time-lapse movies of 22Rv1 cells (labeled with NuclightGreen) and SHP-77 cells (labeled with NuclightRed) co-cultured with T cells. Both the 22Rv1 and SHP-77 cells were plated at equal densities and treated with either NT control BiTE®, AMG 757, or the PSMA-targeting HLE BiTE, AMG 160. T cells were added to each well at an E:T ratio of 10:1. Images were captured every 4 hours at 4x magnification for 5 days.
a.	22Rv1, SHP-77, and T cells co-cultured with NT control BiTE®.
b.	22Rv1, SHP-77, and T cells co-cultured with AMG 757.
c.	22Rv1, SHP-77, and T cells co-cultured with AMG 160.</p>
Supplementary MovieS1b from Immunotherapeutic Targeting and PET Imaging of DLL3 in Small-Cell Neuroendocrine Prostate Cancer
Authors: Chou Jonathan , Egusa Emily A. , Wang Sinan , Badura Michelle L. , Lee Fei , Bidkar Anil P. , Zhu Jun , Shenoy Tanushree , Trepka Kai , Robinson Troy M. , Steri Veronica , Huang Jiaoti , Wang Yuzhuo , Small Eric J. , Chan Emily , Stohr Bradley A. , Ashworth Alan , Delafontaine Brant , Rottey Sylvie , Cooke Keegan S. , Hashemi Sadraei Nooshin , Yu Brian , Salvati Mark , Bailis Julie M. , Feng Felix Y. , Flavell Robert R. , Aggarwal Rahul 
Published: March 2023

<p>Supplemental Movies 1a-1d: 22Rv1-LacZ and 22Rv1-DLL3 cells co-cultures. Time-lapse movies of 22Rv1-LacZ and 22Rv1-DLL3 cells (labeled with NuclightRed) co-cultured with T cells and either NT control BiTE® or AMG 757. T cells were plated at an E:T ratio of 5:1. Images were captured every 6 hours at 10x magnification.
a.	22Rv1-LacZ cells and T cells treated with NT control BiTE®.
b.	22Rv1-DLL3 cells and T cells treated with NT control BiTE®.
c.	22Rv1-LacZ cells and T cells treated with AMG 757.
d.	22Rv1-DLL3 cells and T cells treated with AMG 757.</p>
Early On-treatment Changes in Circulating Tumor DNA Fraction and Response to Enzalutamide or Abiraterone in Metastatic Castration-Resistant Prostate Cancer
Authors: Tolmeijer Sofie H. , Boerrigter Emmy , Sumiyoshi Takayuki , Kwan Edmond M. , Ng Sarah W.S. , Annala Matti , Donnellan Gráinne , Herberts Cameron , Benoist Guillemette E. , Hamberg Paul , Somford Diederik M. , van Oort Inge M. , Schalken Jack A. , Mehra Niven , van Erp Nielka P. , Wyatt Alexander W. 
Published: March 2023

Abstract

Purpose:
Androgen receptor pathway inhibitors (ARPI) are standard of care for treatment-naïve metastatic castration-resistant prostate cancer (mCRPC), but rapid resistance is common. Early identification of resistance will improve management strategies. We investigated whether changes in circulating tumor DNA (ctDNA) fraction during ARPI treatment are linked with mCRPC clinical outcomes.

Experimental Design:
Plasma cell-free DNA was collected from 81 patients with mCRPC at baseline and after 4 weeks of first-line ARPI treatment during two prospective multicenter observational studies (NCT02426333; NCT02471469). ctDNA fraction was calculated from somatic mutations in targeted sequencing and genome copy-number profiles. Samples were classified into detected versus undetected ctDNA. Outcome measurements were progression-free survival (PFS) and overall survival (OS). Nondurable treatment response was defined as PFS ≤6 months.

Results:
ctDNA was detected in 48/81 (59%) baseline and 29/81 (36%) 4-week samples. ctDNA fraction for samples with detected ctDNA was lower at 4 weeks versus baseline (median 5.0% versus 14.5%, P = 0.017). PFS and OS were shortest for patients with persistent ctDNA at 4 weeks (univariate HR, 4.79; 95% CI, 2.62–8.77 and univariate HR, 5.49; 95% CI, 2.76–10.91, respectively), independent of clinical prognostic factors. For patients exhibiting change from detected to undetected ctDNA by 4 weeks, there was no significant PFS difference versus patients with baseline undetected ctDNA. ctDNA change had a positive predictive value of 88% and negative predictive value of 92% for identifying nondurable responses.

Conclusions:
Early changes in ctDNA fraction are strongly linked to duration of first-line ARPI treatment benefit and survival in mCRPC and may inform early therapy switches or treatment intensification.
See related commentary by Sartor, p. 2745