bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of Bipolar Disorder on Maternal and Fetal Health during Pregnancy: a systematic review with meta-analysis
Authors: Mohamed Malak A. , Elhelbawy Abdulrahman , Khalid Maria , AbdAllatif Latifa A. , Lialy Hagar E. 
Published: January 2023

Abstract
Background
Bipolar disorder, or manic-depressive illness, is a mental health condition characterized by mood shifts from severe depression to elevated mood or mania. Pregnant women with BD may experience manic or depressive episodes during gestation, delivery, or postpartum, so they are usually concerned about the effects of BD on their health and their fetal health. The aim of this systematic review is to determine the effects of BD on maternal health and fetal health, weight, and development. It also addresses how BD affects the probability of incidence of pregnancy and labor complications in women with bipolar compared to healthy controls.
Methods
Three electronic databases (Cochrane, PubMed, and ScienceOpen) were searched, and 1193 eligible studies were identified. After deduplication, screening, and manual search processes, we included only 7 studies. Descriptive analysis, meta-analysis, and calculation of the conditional probability of incidence for each pregnancy outcome were used to analyze the results.
Results
The findings of the included studies suggest that BD during pregnancy affects both fetal growth and maternal health by increasing the risk of giving birth to a neonate with some birth defects such as microcephaly, small for gestational age, and other congenital anomalies, in addition to causing some obstetric complications such as gestational hypertension, preterm labor, need for assisted delivery and others.
Conclusion
Bipolar disorder during pregnancy negatively affects mothers and their fetuses and increases the probability of incidence of obstetrics complications.
A Network medicine approach to study comorbidities in heart failure with preserved ejection fraction
Authors: Lanzer Jan David , Valdeolivas Alberto , Pepin Mark , Hund Hauke , Backs Johannes , Friederich Hans-Christoph , Schultz Jobst Hendrik , Saez-Rodriguez Julio , Levinson Rebecca Terrall 
Published: January 2023

Abstract
Background Comorbidities are expected to impact pathophysiology of heart failure (HF) with preserved ejection fraction (HFpEF). However, comorbidity profiles are usually reduced to a few comorbid disorders. Systems medicine approaches can model multiple comorbidities to help to improve our understanding of HFpEF.
Methods We retrospectively explored 569 comorbidities documented in 29,074 HF patients, including 8,062 HFpEF and 6,585 heart failure with reduced ejection fraction (HFrEF) patients from a German university hospital. To analyze comorbidity profiles, first we assessed differences between comorbidity profiles by HF subtype. We fit machine learning classifiers to discriminate between HFpEF and HFrEF patients to interpret important comorbidities. Then we built a network to represent comorbid relationships in HF patients (HFnet) and identified main disease clusters. Lastly, we performed novel gene candidate prediction for HFpEF by linking the HFnet to a multi-layer gene network by integrating multiple databases (HFhetnet). To corroborate HFpEF candidate genes, we collected transcriptomic data in a murine HFpEF model. We compared predicted genes with the murine disease signature as well as with the literature.
Results We found that comorbidity profiles vary more in association with HFpEF/HFrEF status than with age or sex. The comorbidities present in HFpEF patients were more diverse than those in HFrEF, and included neoplastic, osteologic and rheumatoid disorders, among others. Disease communities in the HFnet captured important comorbidity concepts of HF patients which could be assigned to HF subtypes, age groups and sex. Within the HFhetnet, we predicted novel gene candidates, including genes involved in fibrosis (COL3A1, MMP1, LOX), oxidative stress (NOS1, GSST1, XDH) and endoplasmic reticulum stress (ATF6). Finally, predicted genes were significantly overrepresented in the murine transcriptomic disease signature.
Conclusion We applied systems medicine concepts to analyze comorbidity profiles in a HF patient cohort. We were able to identify disease clusters that helped to characterize HF patients. We derived a distinct comorbidity profile for HFpEF, which was leveraged to suggest novel candidate genes via network propagation. The identification of distinctive comorbidity profiles and candidate genes from routine clinical data will provide insights that may be leveraged to improve diagnosis and treatment for HFpEF patients.
Digital Twins and Cultural Heritage Preservation: A Case Study of Best Practices and Reproducibility in Chiesa dei SS Apostoli e Biagio
Authors: Hutson James , Weber Joesph , Russo Angela 
Published: January 2023

AbstractThe use of digital twin technologies to preserve cultural heritage has become increasingly common over the past two decades. Evolving from the use of virtual environments (VE) and digital reconstructions that required multiple phases of workflow and multiple software applications and various hardware to output a useable experience to the immediacy of 3D artificial intelligence (AI) generative content and the latest generation of photogrammetric scanning, non-specialists are now able to more easily create digital twins. At the same time, destruction of cultural heritage has accelerated due to geopolitical instability, seen in examples such the invasion of Ukraine by Russia (2022). Even with advances in user-friendly and commercially available technologies, digital art history and the digital humanities are in a race against time to train and equip enough individuals onsite to create digital twins before more irreplaceable cultural artifacts and sites are lost to natural disaster, accelerated by climate change, or through armed conflict. However, there remains no international standards for methodological reproducibility and the techniques used currently by many scholars include specialized training and knowledge. As such, this paper presents a case study that addresses reproducibility and explainability in the digital humanities through a detailed workflow of the creation of a digital twin of Chiesa dei SS Apostoli e Biagio in Florence, Italy. A model is presented that is scalable and leverages widely available, user-friendly 360 cameras and photogrammetry with LiDAR to capture cultural heritage sites with best practices on how to quickly and effectively train non-specialists to create site-specific digital twins of a variety of cultural heritage structures.
The AT-hook is an evolutionarily conserved auto-regulatory domain of SWI/SNF required for cell lineage priming
Authors: Saha Dhurjhoti , Hailu Solomon , Hada Arjan , Lee Junwoo , Luo Jie , Ranish Jeff , Feola Kyle , Lin Yuan-chi , Jain Abhinav , Liu Bin , Lu Yue , Sen Payel , Bartholomew Blaine 
Published: January 2023

Abstract
The SWI/SNF ATP-dependent chromatin remodeler is a master regulator of the epigenome; controlling pluripotency and differentiation. Towards the C-terminus of the catalytic subunit of SWI/SNF is a motif called the AT-hook that is evolutionary conserved. The AT-hook is present in many chromatin modifiers and generally thought to help anchor them to DNA. We observe the AT-hook however regulates the intrinsic DNA-stimulated ATPase activity without promoting SWI/SNF recruitment to DNA or nucleosomes by increasing the reaction velocity a factor of 13 with no accompanying change in substrate affinity (KM). The changes in ATP hydrolysis causes an equivalent change in nucleosome movement, confirming they are tightly coupled. Attenuation of SWI/SNF remodeling activity by the AT-hook is important in vivo for SWI/SNF regulation of chromatin structure and gene expression in yeast and mouse embryonic stem cells. The AT-hook in SWI/SNF is required for transcription regulation and activation of state-specific enhancers critical in cell lineage priming. Similarly, the AT-hook is required in yeast SWI/SNF for activation of genes involved in amino acid biosynthesis and metabolizing ethanol. Our findings highlight the importance of studying SWI/SNF attenuation versus eliminating the catalytic subunit or completely shutting down its enzymatic activity.
Effects of Compulsory Upper-Secondary Education on Financial Inclusion
Authors: Park Eunjung , Yi Sangyoon 
Published: January 2023

Abstract
To enable sustainable financial inclusion, various policies are enforced internationally; however, there are diverse opinions on their effectiveness. Previous research has shown that education is necessary for individuals to understand financial products and services. Therefore, financial initiatives including financial education are considered crucial. This study aimed to analyze the effects of compulsory education on financial inclusion, from a variety of sociodemographic characteristics. We analyzed global data collected per country by the World Bank, the United Nations Development Programme, and the International Monetary Fund. It used an instrumental variable model that modelled the expected years of schooling and the human rights index as instruments. The results demonstrated that compulsory upper-secondary education had a positive effect on financial inclusion at all socioeconomic levels, except for people aged 60 years or older. For women, compulsory upper-secondary education had the greatest effect on financial inclusion. Contrastingly, we found that the completion of lower-secondary education was sufficient to promote financial inclusion in the high-income class, while other groups needed to complete their upper-secondary education at least. This study provides valuable insights to help establish feasible policies and strategies for the financial inclusion of the socially marginalized groups we are interested in.
Genetic diversity of Melia dubia as revealed by molecular markers
Authors: DARYAL UNSHANI , Dobhal Shivani , Kumar Ashok , Panwar Neha Singh 
Published: January 2023

Abstract

Background
Melia dubia Cav. of the family Meliaceae is a highly valued multipurpose tree species that has a short rotation period and can be harvested for various industrial and domestic wood requirements. However, the availability of genetically improved planting stock is almost non-existent, especially in North East India, and formulating management and conservation strategies are highly in need as it was observed during the survey that the number of Melia trees was very less and the majority of it was found fragmented in home-gardens.
Methods and Results
In the present study, a survey was conducted on the natural population in 11 villages of East Siang District, Arunachal Pradesh and 34 phenotypically superior Melia trees were selected based on the characteristics viz. height, clear bole height, girth at breast height, collar girth, crown diameter, straightness and branching. East Siang district of Arunachal Pradesh occupies a geographical area of 3,603 sq. km and a forest cover of 2911.67 sq. km. Genetic diversity of 34 selected trees is estimated with 15 microsatellite markers (SSR). Five out of fifteen SSR primers were found to be polymorphic. The effective number of alleles (Ne = 1.88), Nei’s gene diversity (h = 0.47), polymorphism information content (PIC = 0.48) and Shannon’s index (I = 0.66).
Conclusion
It is affirmed by the UPGMA dendrogram and the pair-wise genetic dissimilarity that there is no association between the genetic and geographic distance of the genotypes. Understanding the genetic variability of M. dubia will help to identify superior seed sources for improvement programs and conservation strategies for the species.
Male sterility and hybrid breeding in soybean
Authors: Fang Xiaolong , Sun Yanyan , Li Jinhong , Li Meina , Zhang Chunbao 
Published: January 2023

Abstract
Hybrid breeding can help us to meet the challenge of the growing world population with limited agricultural land. The demand for soybeans is expected to grow, however the hybrid soybean is still in the process of commercialization even though considerable progress has been made in soybean genome and genetic studies in recent years. Here, we summarize recent advances on male sterility-based breeding programs and the current status of hybrid soybean breeding. A number of male-sterile lines with cytoplasmic male sterility (CMS), genic-controlled photoperiod/ thermo-sensitive male sterility (GMS) and nuclear male-sterile mutants have been identified in soybean. More than 40 hybrid soybean varieties have been bred using the CMS three-line hybrid system and the cultivation of hybrid soybean still under way. The key to speed up hybrid soybean breeding is to increase the out-crossing rate in an economical way. This review outlines the problems with current hybrid soybean breeding systems and explores the current effort in making the hybrid soybean a commercial success.
Prevalence of undernutrition and change detection among under-five children of EAG states in India: scrutinizing from NFHS-4 and NFHS-5
Authors: Roy Arabinda , Rahaman Mostafijur 
Published: January 2023

Abstract

Background: Nowadays undernutrition among the under five children is a serious public health problem in the developing countries like India. There are EAG states in India which are socio-economically backward in term of demographic and epidemiological transition, characterized by high population growth rate, high infant child morality and high fertility. The current study was conducted to assess the changes of the indicator of undernutrition with the help of anthropometric measurement of under five children and represent the current (NFHS-5, 2019-21) prevalence of child undernutrition among the EAG states of India. Methods The state level data of undernutrition were extracted from state fact sheet of India, published by NFHS, India. The study is based on two time series of NFHS (NFHS-4 & NFHS-5. The changes of undernutrition indices in the EAG states were estimated by differentiate the last series prevalence from the previous series prevalence. Also thematic map were used to show spatial distribution of undernutrition indices of the latest NFHS series (NFHS-5). Result From the result it is found that the prevalence of stunting and underweight are decreased in all the EAG states and the decreasing pattern is more than the national level but the prevalence of wasting is only increased in Bihar. The NFHS-5 report shows that the prevalence of stunting and underweight in most of the EAG states has still more than 30%. Conclusions To reduce undernutrition among under-5 children there is need some target oriented policies which will help in improving the socio economic status of the children’s family as well as maternal and child health. Enhance the level of education of mothers, awareness and raising the economic as well as socio-political empowerment of mothers is essential to reduce the undernutrition status. This study will be beneficial for the health workers and policy makers to understand the prevalence and changing pattern of undernutrition among the children of EAG states.
WITHDRAWN: Estimating the Income of the January 6, 2021 Insurrectionists
Authors: Komlos John 
Published: January 2023

Abstract
The income of those who attacked the U.S. Congress on January 6, 2021 and were subsequently arrested is estimated using the income in the neighborhood of their residence as a proxy measure. Contrary to common wisdom, we find that the income of the arrestees was not at all similar to that of the population at large. Three groups were conspicuously underrepresented from this subset of the insurrectionists: the poor (whose annual personal income was below $20K), the upper-middle class, and the superrich. Fully 83% of the arrestees resided in areas with an average annual personal income between $20K and $50K. This finding dovetails with the argument that the right-wing populist movement is driven primarily by those who were left behind by the transition from an industrial to a post-industrial economy.
Behavior in Financial Management in a Demographic Analysis
Authors: Silva Erlon Andrade Da , Sodré Plínio Roberto Souza , Gomes Francinaldo Lobato , Cruz Laís Pinho 
Published: January 2023

Abstract
Purpose: Based on the analysis of the behavior in financial management (BFM) of a group of doctors who graduated from the State of Bahia, we investigated the differences in behavior in personal finances based on some demographic variables.
Methodology:In the population study, we used the Financial Management Behavior Scale (FMBS), plus demographic questions and scores tostratify and quantify the sample's BFM.
Findings:The comparison between the BFM of the different generations was not statistically relevant, possibly pointing to the changes that have been taking place both in medical demography and society. We found a statistically significant difference between the BFM in terms of gender and when we analyzed the profile of participation in the household's income about insurance adherence.
Social implications: The relativelylow total score of the BFM in the population studied is worrying and allows us to predict more alarming results for Brazilian demography.
JEL Codes: D91, I22, G5, A20, C92.
Effects of Curvature Direction on Friction Stir Welding Lap Joint of Aluminum Alloy "S" Curved Surface
Authors: Xiao Xuan , Mao Yue , Wang Xincheng , Qin Dingqiang , Fu Li 
Published: January 2023

Abstract
In this paper, the friction stir welding (FSW) of single-curvature and double-curvature "S" curved surface lap joints were realized using split type pressing blocks fixture and robotic system with welding parameter 1400rpm, 150mm/min. By Finite Element Method (FEM) and axial force analysis, the effects of curvature direction on friction stir welding lap joint of 5083 Aluminum Alloy "S" Curved surface is explored. The results show that Z-axis curvature direction has important influence on joint forming. By split type pressing blocks fixture, the material thermal expansion causes upward force F’ in Z-axis positive curvature position, but causes downward force F’ in Z-axis negative curvature position. So Z-axis positive curvature makes the actual axial compressive force FR (FR=FN-F’) smaller than the device input FN. Which decreases the interface stress of the lap joint and increases the tendency of upper plate edges bending deformation and the probability of interface defects. Finally, the joint mechanical properties are reduced, the tensile load can be as low as 1.5 kN. While Z-axis negative curvature makes the actual axial compressive force FR (FR=FN+F’) greater than the device input FN. Which increases the interface stress of the lap joint. Meanwhile it decreases the tendency of upper plate edges bending deformation and leads to the interface defects disappearing. So the joint mechanical properties are good, the tensile load can be more than 2.4 kN. For Y-axis curvature direction, its impact is mainly shown in changing the direction of resultant force FR. In Y-axis positive curvature position, the force FR lies between Y positive direction and Z negative direction. While in Y-axis negative curvature position, the force FR lies between Y negative direction and Z negative direction. The inclination of force FR is helpful to eliminate the interface defects of the joint. At the same time, it will cause inconsistent stress between the advancing side (AS) and the retreating side (RS) of the joint interface, which is the reason that the double-curvature lap joint welding process is unstable.
Theoretical study of the interaction of nanotubes with Venlafaxine, Azithromycin, Erythromycin and Ciprofloxacin
Authors: Raoufi Arastou , Kiaeefar Ali , Raoufi Amir Mahdi , Rajabi Negar , Ismailzadeh Amir 
Published: January 2023

Abstract
The current paper investigated Venlafaxine, Azithromycin, Erythromycin and Ciprofloxacin medications absorption properties interactions with single-walled carbon nanotubes (SWNT). All calculations were performed by using Gaussian 09 software. Calculations were applied to atoms using the B3LYP theory that is the famous function of DFT method and basis set 6-31G (d, p). The atoms are calculations were all performed at Quantum level. Using the above method, all systems’ degrees of freedom was optimized. It is worth noting that all calculations were carried out in the gas phase. The current paper investigated Van der Waals attraction of the medication on the SWNT (5, 5). Van der Waals was studied in the gas phase configuration. The binding energy depends on the group on which CNT is absorbed in Van der Waals attraction.
Impact of Disease Burden on Clinical Outcomes of AML Patients Receiving Allogeneic Hematopoietic Cell Transplantation: A Study from the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation.
Authors: Bazarbachi Ali , dalle iman abou , Labopin Myriam , schroeder thomas , Finke Jürgen , Stelljes Matthias , neubauer Andreas , Blaise Didier , Agha Ibrahim Yakoub , Salmenniemi Urpu , Forcade Edouard , Itälä-Remes Maija , Dreger Peter , Bug Gesine , Heuser Michael , Choi Goda , Brissot Eolia , Giebel Sebastian , Nagler Arnon , Ciceri Fabio , Mohty Mohamad , Kroeger Nicolaus , Passweg Jakob 
Published: January 2023

Abstract
Pre-transplant detectable measurable residual disease (MRD) is still associated with high risk of relapse and poor outcomes in acute myeloid leukemia (AML). We aimed at evaluating the impact of disease burden on prediction of relapse and survival in patients receiving allogeneic hematopoietic cell transplantation (allo-HCT) in first remission (CR1). We identified a total of 3202 adult AML patients, of these 1776 patients were in CR1 and MRD positive and 1426 patients were primary refractory at time of transplant. After a median follow-up of 24.4 months, non-relapse mortality and relapse rate were significantly higher in the primary refractory group compared to the CR1 MRD positive group (Hazards Ratio (HR)=1.82 (95% CI: 1.47-2.24) p<0.001 and HR=1.54 (95% CI: 1.34-1.77), p<0.001), respectively. Leukemia-free survival (LFS) and overall survival (OS) were significantly worse in the primary refractory group (HR=1.61 (95% CI: 1.44-1.81), p<0.001 and HR= 1.71 (95% CI: 1.51-1.94), p<0.001, respectively). Our real-life data suggest that patients in CR1 and MRD positive at time of transplant could still be salvaged by allo-HCT with a 2-year OS of 63%, if negative MRD cannot be obtained and their outcomes are significantly better than patients transplanted with active disease.
Mold-Free Self-Assembled Scalable Microlens Arrays with Ultrasmooth Surface and Record-high Resolution
Authors: Zhou Guofu , Liu Zhihao , Hu Guangwei , Huapeng Ye , Wei Miaoyang , Zhenghao Guo , Chen Kexu , Liu Chen , Tang Biao 
Published: January 2023

Abstract
Microlens arrays (MLAs) based on the selective wetting have opened new avenues for developing compact and miniaturized imaging and display techniques with ultrahigh resolution beyond the traditional bulky and volumetric optics. However, the selective wetting lenses explored so far have been constrained by the lack of precisely defined pattern for highly controllable wettability contrast, thus limiting the available droplet curvature and numerical aperture, which is a major challenge towards the practical high-performance MLAs. Here we report a mold-free and self-assembly approach of mass-production of scalable MLAs, which can also have ultrasmooth surface, ultrahigh resolution, and the large tuning range of the curvatures. The selective surface modification based on tunable oxygen plasma can facilitate the precise pattern with adjusted chemical contrast, thus creating large-scale microdroplets array with controlled curvature. The numerical aperture of the MLAs can be up to 0.3 and precisely tuned by adjusting the modification intensity or the droplet dose. The fabricated MLAs have high-quality surface with subnanometer roughness and allow for record-high resolution resolution imaging up to equivalently 2116 ppi, as we demonstrated. This study shows a cost-effective roadmap for mass-production of high-performance MLAs, which may find applications in the rapid proliferating integral imaging industry and high-resolution display.