bluuebunny/crossref_metadata_2025_split huggingface dataset:
Non‐invasive prenatal testing for the detection of trisomies 21, 18, and 13 in pregnant women with various clinical indications: A multicenter observational study of 1,854,148 women in China
Authors: Xiang Liangcheng , Zhu Jun , Deng Kui , Li Qi , Tao Jing , Li Mingrong , Wang Yanping , Yuan Xuelian , Yao Yongna , Li Xiaohong 
Published: January 2023

AbstractObjectiveThis study aimed to evaluate the performance of noninvasive prenatal testing (NIPT) for detecting three common trisomies (T21, T18, and T13) in pregnant women with diverse clinical indications.MethodsFrequencies of NIPT, of high chance of having one of the three trisomies, and of confirmed trisomies were determined for women with each of seven clinical indications in a national cross‐sectional survey of approximately 300 prenatal diagnosis centers. Data were collected for the period from October 1, 2016 to September 30, 2018 using the Prenatal Diagnosis Technology Management On‐line Information System. The performance of NIPT for detecting the three trisomies in pregnant women with different clinical indications was assessed in terms of sensitivity, specificity, positive predictive value (PPV), negative predictive value, and the corresponding 95% confidence intervals.ResultsA total of 5766 true positive cases for T21, T18, and T13 were detected among 1,854,148 samples, giving an overall detection rate of 0.31% (95% CI: 0.30%–0.32%). Most positive cases were associated with “NT thickening” (1.18%) and “advanced maternal age” (0.51%). The detection sensitivities of NIPT were 99.60% for T21, 99.14% for T18, and 100% for T13, while the corresponding specificities were 99.90%, 99.94%, and 99.95%. The corresponding PPVs were 69.77%, 47.24%, and 22.36%. NIPT showed high sensitivity and specificity, regardless of clinical indication. In contrast, PPV for three trisomies varied widely between 9.09% and 66.46% depending on the clinical indication. Across seven clinical indications, PPV ranged from 50.62% to 73.09% for T21, 20.00%–58.33% for T18, and 4.17%–47.37% for T13. The highest PPVs were 73.09% for T21 in pregnancies involving “advanced maternal age”, 58.33% for T18 in pregnancies with “NT thickening”, and 47.37% for T13 in pregnancies with “NT thickening”.ConclusionsNIPT shows high sensitivity and specificity for detecting T21, T18, and T13 in pregnant women with different clinical indications. However, PPV depends strongly on clinical indication, highlighting the need to strengthen education and genetic counseling about prenatal screening.
Comparative evaluation of biased agonists Sarcosine1, d‐Alanine8‐Angiotensin (Ang) II (SD Ang II) and Sarcosine1, Isoleucine8‐Ang II (SI Ang II) and their radioiodinated congeners binding to rat liver membrane AT1 receptors
Authors: Noto Natalia M. , Restrepo Yazmin M. , Pang Hong W. , Stoyell‐Conti Filipe , West Crystal A. , Speth Robert C. 
Published: January 2023

AbstractAngiotensin II analogue and β‐arrestin biased agonist TRV027 (Sarcosine1, d‐Alanine8‐Angiotensin (Ang) II; SD Ang II), developed by Trevena, Inc. in the early 2010s, brought hopes of a novel treatment for cardiovascular diseases, due to its ability to simultaneously cause signaling through the β‐arrestin signaling pathway, while antagonizing the pathophysiological effects of Ang II mediated by the AT1 receptor G protein signaling cascades. However, a phase II clinical trial of this agent revealed no significant benefit compared to placebo treatment. Using 125I‐Sarcosine1, Isoleucine8‐Ang II (125I‐SI Ang II) radioligand receptor competition binding assays, we assessed the relative affinity of TRV027 compared to SI Ang II for liver AT1 receptors. We also compared radioiodinated TRV027 (125I‐SD Ang II) binding affinity for liver AT1 receptors with 125I‐SI Ang II. We found that despite its anticipated gain in metabolic stability, TRV027 and 125I‐SD Ang II had reduced affinity for the AT1 receptor compared with SI Ang II and 125I‐SI Ang II. Additionally, male–female comparisons showed that females have a higher AT1 receptor density, potentially attributed to tissue‐dependent estrogen and progesterone effects. Peptide drugs have become more popular over the years due to their increased bioavailability, fast onset of action, high specificity, and low toxicity. Even though Trevena®'s biased agonist peptide TRV027 offered greater stability and potency compared to earlier AT1R biased agonists, it failed its phase II clinical trial in 2016. Further refinements to AT1R biased agonist peptides to improve affinity, as seen with SI Ang II, with better stability and bioavailability, has the potential to achieve the anticipated biased agonism.
Effect of garlic extract on markers of lipid metabolism and inflammation in coronary artery disease (CAD) patients: A systematic review and meta‐analysis
Authors: Gadidala Sai Kumar , Johny Ebin , Thomas Christy , Nadella Mounika , Undela Krishna , Adela Ramu 
Published: January 2023

AbstractSeveral preclinical studies have focused on the beneficial effects of garlic on cardiovascular diseases, but the results were inconsistent. We performed a systematic review and meta‐analysis on the effect of garlic powder tablets and aged garlic extract (AGE) in CAD patients, mainly focusing on blood pressure, coronary artery calcification, lipid profile, and inflammatory markers. We searched PubMed, Cochrane CENTRAL, and Google Scholar to identify randomized controlled trials which examined garlic's effect on CAD patients. The standardized mean difference with 95% CI was calculated using fixed‐effect or random‐effect models. Garlic has shown statistically significant changes of HDL (SMD = 0.18; 95% CI = −0.00 to 0.37; p = .05); LDL (SMD = −0.27; 95% CI = −0.46 to −0.08; p = .004), apolipoprotein‐A (SMD = 0.68; 95% CI = 0.24 1.13; p = .002), C‐RP (SMD = −0.59; 95% CI = −0.92 to −0.25; p = .0007), IL‐6 (SMD = −1.08; 95% CI = −2.17 to 0.01; p = .05), homocysteine (SMD = −0.66; 95% CI = −1.04 to −0.28; p = .0007) and CAC score (SMD = −1.61; 95% CI = −2.66 to −0.57; p = .003). In the case of subgroup analysis, the overall effect was significantly effective in reducing TC, LDL levels and improving HDL levels in CV risk patients. Our study findings provide consistent evidence that intake of garlic reduces CVD risk factors. However, garlic could be considered a safe natural medicine to debilitate inflammation in CAD patients.
The effects of COVID‐19 pandemic on early childhood care systems in Hawaii in 2020
Authors: Okamoto Jeffrey K. , Nitta Keiko , Borrello Kirra , Nakano Shelbi 
Published: January 2023

AbstractThe COVID‐19 pandemic caused many effects on the referrals to and the work of governmental agencies working with young children. This article describes the impact on the use of early childhood evaluations and services in the State of Hawaii. We looked at several nonpublic data sets from the Hawaii Department of Health and Department of Human Services, comparing the rates of early intervention referrals, lead level screening, childhood immunizations, and child welfare referrals in 2019 and 2020. We also describe effects on the work processes in various early childhood programs from the COVID‐19 stay‐at‐home and work mandates. There was a decrease in rates of referrals to early intervention and child welfare services. There was less lead level screening being done, and childhood immunization rates dropped. Some of these issues stem from clinicians not seeing children whose families were worried about bringing their children for routine appointments. These clinicians do a lot of the developmental and lead screening, and much of the immunizations for children. Home visiting programs were interrupted as they could not do in‐person screenings of families. Therefore, they could not easily identify families that benefit from the support of a trained home visitor. The Special Supplemental Nutrition Program for Women, Infants, and Children (WIC) could not do anemia checks or measurements on children's growth. With ongoing COVID‐19 issues in the State of Hawaii, remedies are required given ongoing effects on clinician offices practices and childhood program processes.
Deconstructing corporate environmental, social, and governance performance: Heterogeneous stakeholder preferences in the food industry
Authors: Luque‐Vílchez Mercedes , Gómez‐Limón José A. , Guerrero‐Baena M. Dolores , Rodríguez‐Gutiérrez Pablo 
Published: January 2023

AbstractEnvironmental, social, and governance (ESG) performance assessment has emerged as a way to analyze corporate sustainability. However, the literature suggests that stakeholders are not satisfied with advisory firms' current assessment approaches since they do not consider stakeholders' sustainability preferences. Adopting the stakeholder perspective, this study proposes a new approach to assess ESG performance by developing a stakeholder‐specific composite indicator that considers different stakeholder profiles. The proposed approach is empirically implemented to assess the ESG performance of European food firms, as the food industry plays an essential role in achieving the Sustainable Development Goals. The results provide evidence of differences in individual stakeholders' preferences regarding ESG assessment, even within the same stakeholder group (e.g., investors, consumers, or non‐governmental organizations). However, the results reveal that almost all the stakeholders sampled showed individual firm rankings similar to generic rankings provided by advisory firms. In any case, this evidence suggests the need to reconsider how ESG composite indicators are constructed, underlining the value of enhanced transparency and communication with stakeholders to provide more valuable and reliable composite indicators.
Reliable Detection of Fluoroquinolones in Pharma‐effluents: Increasing Exposure in Environment Triggers Rise of Antimicrobial Resistance
Authors: Mandal Saurodeep , Islam Majharul , Ghosh Priyotosh , Mandal Sukhendu , Sahoo Prithidipa 
Published: January 2023

AbstractThe Fluoroquinolone class of antibiotics is effective till today in treating various antimicrobial infections but their continuous exposure in the environment in sublethal doses enhances the probability of the emergence of antibiotic resistance within bacterial pathogens and as a consequence efficacy of the drug gets compromised. Efforts are being made to check and develop reliable, inexpensive, and portable detection methods to trace antibiotic molecules from their initial sources to various contaminated environments. In this work, an anthraquinone naphthaldehyde conjugate (ANC) was found to be useful in the detection (LOD 6.67×10−8 M) of ofloxacin, levofloxacin producing significant green fluorescence upon UV irradiation. The fluorescence property of ANC was utilized for the differential detection and quantification of fluoroquinolones in pharmaceutical sewage samples. This detection strategy could be beneficial for better monitoring of such contaminants and the establishment of a sustainable environment. The probe can satisfactorily enter and detect ofloxacin in both Bacillus cereus bacterial cell and HuH7 cell line.
Effects of cracks on chloride‐induced corrosion initiation and propagation of carbon and stainless steel rebar
Authors: Russo Nicoletta , Gastaldi Matteo , Schiavi Luca , Strini Alberto , Lollini Federica 
Published: January 2023

AbstractCurrent durability design models for reinforced concrete structures in chloride‐contaminated environments do not consider the effects of cracks, which in practice are almost inevitable. Literature reports controversial results on corrosion propagation time of carbon steel (CS) in cracked concrete, while fewer information can be found on stainless steel (SS) rebar, which can be employed as additional protection strategy. In this experimental study, corrosion initiation and propagation of CS and SS rebar in uncracked and cracked concrete are presented. Prismatic specimens, reinforced with CS and 304L SS bars were subjected to a loading procedure to induce longitudinal micro‐cracks and exposed to a 3.5% NaCl solution for more than 2 years. Corrosion was monitored with electrochemical techniques and at the end of exposure corrosive attacks were observed. Results demonstrate the fundamental contribution of micro‐cracks in accelerating corrosion phenomena for CS, while SS is still in passive conditions also in cracked concrete.
U.S. hegemony and international business research: Further considerations
Authors: Geringer J. Michael , Livanis Grigorios 
Published: January 2023

AbstractThe commentaries in this issue raise many insightful questions and considerations regarding the Livanis and Geringer (Thunderbird International Business Review, 2023, 64) study and we address a few of these. In particular, we focus on the following five areas: (i) the relationship of international business (IB) publications with the English language, (ii) resource constraints and IB research, (iii) institutional rewards and IB research, (iv) methodological considerations in evaluating IB research productivity, and (v) opportunity costs of pursuing a Ph.D. and IB research and publication.
Digital Reading Check‐ins: Supporting Independent Digital Reading
Authors: Pavek Cara , Vaughan Michelle 
Published: January 2023

AbstractWe know that teacher support during independent reading can greatly impact the growth and development of beginning readers. However, the rapid conversion to online learning in the 2020–2021 school year required teachers to rethink and retool traditional strategies to meet the needs of their online learners. This teaching and learning guide explores the use of a digital reading check‐in strategy to support beginning readers as they read independently on digital platforms. We explain how this strategy was implemented successfully in a first‐grade classroom and how it can be employed with any digital reading platform used in classrooms today.
Photobiomodulation therapy combined with static magnetic field in tibial fracture healing of a dog: A case report
Authors: Asteinza Castro Iker M. , Morga Armando Amador , Johnson Douglas Scott 
Published: January 2023

AbstractA 10‐week‐old male, Xoloitzcuintle (Mexican hairless dog), weighing 8.9 kg was presented after its owner accidentally stepped on its paw. The dog presented with acute pain, inflammation and grade IV lameness in the right hind paw. A complete transverse fracture in the right proximal tibia was diagnosed from radiography. The dog underwent a minimally invasive plate osteosynthesis (MIPO) procedure. After surgery, photobiomodulation therapy combined with static magnetic field (PBMT‐sMF) was applied twice daily for 21 days. A multi‐wavelength PBMT‐sMF device was applied at three sites using different frequencies: proximal and distal of the fracture zone (3000 Hz, 40.35 J per site, and 300 s per site) and in the fracture zone (250 Hz, 39.11 J and 300 s per site). Follow up radiographies were performed after surgery and treatment with PBMT‐sMF. Eighteen days post‐surgery the healing process of bone was advanced. Fifty‐five days post‐surgery the callus was enlarged. In addition, radiographic union and clinical union was evidenced by closure of the fracture gap. This case report has reported the use of PBMT‐sMF in order to accelerate and improve bone healing following a MIPO procedure on a complete transverse fracture in the proximal tibia of a puppy.
Impact of the policy framework and institutional setup on urban water supply in Malawi: The case of the Lilongwe Water Board
Authors: Malemba Edith , Masinde Wanyama 
Published: January 2023

AbstractAccess to safe drinking water has been recognized as a basic human right globally by various international bodies and commissions. Sub‐Saharan Africa, in particular, has proven to have insufficient water access in the urban areas because population growth and rapid urbanization are overtaking the already inadequate infrastructure, and disparities in potable water availability are widespread. An enabling policy environment coupled with decentralization has been highlighted to positively affect water service delivery. The study examined the policy and institutional frameworks that exist for urban water supply in Malawi and their interactions with each other as well as with the water utility, Lilongwe Water Board. Data were collected through key informant interviews with officials from institutions involved in urban water supply and through literature review. Content analysis coupled with thematic analysis was used to analyze the data for key emerging themes. It was found that there is poor coordination between the board and the Lilongwe City Council, which is exacerbated by the existing conflicting policies on institutional roles and jurisdictions in urban water supply. Low participation in joint activities and the long bureaucratic process affect Lilongwe Water Boards' efforts of service delivery. There is a need for both a separate water supply policy and a regulatory body for water service delivery to ensure good water supply. Recommendations for future work on the setup of the water utility itself and the impact on urban water supply were also made.
Bonding in PdCl(NO) and Related Nitrosylmetal Species of the Enemark–Feltham {MNO}10Type
Authors: Schröder Daniel , Klüfers Peter 
Published: January 2023

AbstractThe crystal‐structure analysis of the coordination polymer PdCl(NO) (1) by Evers et al. shows a two‐dimensional PdCl network of four‐coordinate Pd atoms and triply bridging chlorido ligands. The fourth ligand at Pd is a terminally bonded nitrosyl ligand in a bent PdNO function (Pd−N−O=129°). In terms of the Enemark–Feltham notation,1is an {MNO}10compound which leaves a choice regarding the assignment of the ten electrons as d10‐Pd0Cl−(NO+), d9‐PdICl−(NO) or d8‐PdIICl−(NO−) with 0, 1 and 2 electrons allocated at the nitrosyl ligand, respectively. The quantum‐chemical treatment by DFT methods and subsequent determination of the oxidation states (OSs) by Salvador's Effective‐OS (EOS) method shows highly covalent Pd−NO bonds which narrowly end up on the Pd0Cl−(NO+) side in the course of the OS assignment's heterolytic bond‐cleavage procedure. Related halonitrosyls are included to examine the obvious suitability of both linear and bent MNO units as ‘ground‐state canditates’ of {MNO}10systems. Local‐mode analysis confirmed the recently formulated weakening of both the metal−nitrosyl and the N−O bond on bending a linear MNO function.
The Initial Impact of Technology Enabled Relationship Creation in Rural Lebanon
Authors: Inversini Alessandro , Müller Maxie , Talhouk Salma 
Published: January 2023

AbstractTechnology enables actor-to-actor experience co-creation leading to value creation for the parties involved in the process. This research presents the initial impact of a mobile application developed to foster technology enabled relationship in rural Lebanon. Results indicate that technology has the potential to positively impact both host and guest fostering relationships building in all the trip stages and leading to socio-economic development and transformative experiences. In fact, the paper shows that relationships created and strengthened with the support of technology are expected to have effects at personal, community and business level.
Where You Sleep Tells What You Care About
Authors: Marine-Roig Estela , Daries Natalia , Martin-Fuentes Eva , Ferrer-Rosell Berta 
Published: January 2023

AbstractOnline reviews are valuable sources of information that can help other tourists gain an idea of the destination they seek. The aim of this research is to examine what types of content is reviewed by hotel guests and Airbnb guests in two of the main urban tourist cities in Spain (Barcelona and Madrid) to distinguish content between the destination where the accommodation is located and to observe variations on users of these platforms when they write reviews. Comparing more than one million reviews posted on TripAdvisor and Airbnb through compositional data analysis (CoDa), results show that there are different patterns between Barcelona and Madrid and between their accommodation mode according to the reviews. This study can help researchers and managers know what useful information can be extracted from online travel reviews.
Exploring Post-COVID-19 Branding Strategies of African Destinations
Authors: Ukpabi Dandison , Quarshie Benjamin , Karjaluoto Heikki 
Published: January 2023

AbstractThe lifting of COVID-19 restrictions has led to the opening of many tourism destinations, with many destination marketing organizations (DMOs) adopting different strategies to attract tourists. This study explores the post-COVID-19 branding strategies of four award-winning African destinations (South Africa, Kenya, Morocco, and Mauritius) and how they utilize social media to communicate their destination brand identities. We curated the tweets of the National Tourism Boards of the examined destinations from their official Twitter accounts and analyzed them using Atlas.ti. We found that each of the destinations uniquely identifies and communicates its destination’s competitive advantages. We provide insights and implications.
Back in Time with Immersive Heritage Tourism Experience: A Study of Virtual Reality in Archaeological Sites
Authors: Bideci Mujde , Bideci Caglar 
Published: January 2023

AbstractThis study focuses on how virtual reality applications might evoke nostalgic sensations in travellers during cultural heritage tourism. While extensive research on the tourism experience has revealed different extrinsic and intrinsic dynamics that affect the tourist experience, this research aims to explore what feeling of back in time VR users experience in an archaeological destination. The gap in visitor experience employing VR research still persists, despite the rising adoption rate of immersive technology, such as virtual reality. In this study, a qualitative method has been applied to analyse online reviews of VR users who visited the Olympia Archaeological Site in Greece and used the ‘Back in Time Olympia’ VR application. The findings drawn from the results show that nostalgia, presence, engagement by learning, and service experience are essential determinants of tourist VR experiences in such cultural heritage destinations.
Legal Considerations on the Relationship Between Tourism Marketing and AR
Authors: Ide Akira 
Published: January 2023

AbstractAugmented reality (AR) is greatly changing the tourism scene in this decade. With the recent expansion of AR, it is now possible to obtain digital flyers and coupons by physically visiting a place. Various AR-based games, such as Pokémon Go, have encouraged many people to visit various locations in the real world. However, the use of AR as a marketing strategy to attract customers and induce movements in humans has created new legal issues, such as the appropriateness of placing coupons on private properties and its use in public parks by private companies for sales promotions. In addition, since AR can make valuable digital information appear in a space for a specific period, it raises new issues regarding time management. This paper considers the problems that arise in guiding people using AR, mainly from a legal perspective, and discusses the future direction.