bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dysregulation of astrocyte-secreted pleiotrophin contributes to neuronal structural and functional deficits in Down Syndrome
Authors: Brandebura Ashley N. , Asbell Quinn N. , Micael Mariel Kristine B. , Allen Nicola J. 
Published: September 2023

SummaryNeuronal dendrite patterning and synapse formation are tightly regulated during development to promote proper connectivity. Astrocyte-secreted proteins act as guidance and pro-synaptogenic factors during development, but little is known about how astrocytes may contribute to neurodevelopmental disorders. Here we identify down-regulation of the astrocyte-secreted molecule pleiotrophin as a major contributor to neuronal morphological alterations in the Ts65Dn mouse model of Down Syndrome. We find overlapping deficits in neuronal dendrites, spines and intracortical synapses in Ts65Dn mutant and pleiotrophin knockout mice. By targeting pleiotrophin overexpression to astrocytes in adult Ts65Dn mutant micein vivo, we show that pleiotrophin can rescue dendrite morphology and spine density and increase excitatory synapse number. We further demonstrate functional improvements in behavior. Our findings identify pleiotrophin as a molecule that can be used in Down Syndrome to promote proper circuit connectivity, importantly at later stages of development after typical periods of circuit refinement have completed.
An environmental-based perspective framework: integrating IoT technology into a sustainable automotive supply chain
Authors: El Jaouhari Asmae , Arif Jabir , Samadhiya Ashutosh , Kumar Anil , Garza-Reyes Jose Arturo 
Published: September 2023

PurposeOver the next decade, humanity is going to face big environmental problems, and considering these serious issues, businesses are adopting environmentally responsible practices. To put forward specific measures to achieve a more prosperous environmental future, this study aims to develop an environment-based perspective framework by integrating the Internet of Things (IoT) technology into a sustainable automotive supply chain (SASC).Design/methodology/approachThe study presents a conceptual environmental framework – based on 29 factors constituting four stakeholders' rectifications – that holistically assess the SASC operations as part of the ReSOLVE model utilizing IoT. Then, experts from the SASC, IoT and sustainability areas participated in two rigorous rounds of a Delphi study to validate the framework.FindingsThe results indicate that the conceptual environmental framework proposed would help companies enhance the connectivity between major IoT tools in SASC, which would help develop congruent strategies for inducing sustainable growth.Originality/valueThis study adds value to existing knowledge on SASC sustainability and digitalization in the context where the SASC is under enormous pressure, competitiveness and increased variability.
An exploratory study of benefits and challenges of neurodivergent employees: roles of knowing neurodivergents and neurodiversity practices
Authors: Ali Muhammad , Grabarski Mirit K. , Baker Marzena 
Published: September 2023

PurposeNeurodiversity refers to a spectrum of neurological differences. Little is known about the benefits and challenges of employing neurodivergent individuals in the retail industry and how knowing neurodivergent individuals/neurodiversity practices are linked to benefits/challenges. This study provides these insights using the lenses of the value-in-diversity perspective, stigma theory and intergroup contact theory.Design/methodology/approachData were collected from an online survey of retail supervisors and co-workers from Australia, resulting in 502 responses from various retail organizations.FindingsThe findings indicate that supervisors have higher awareness of neurodiversity and perceived benefits of neurodivergent employees. Knowing neurodivergents was positively associated with perceived benefits and disclosure challenges and negatively associated with equity and inclusion challenges. Neurodiversity practices were positively associated with benefits of neurodivergent employees, negatively associated with disclosure challenges and equity and inclusion challenges in small stores, and positively associated with equity and inclusion challenges in large stores.Originality/valueCurrent empirical research on workplace neurodiversity is scarce. This study provides pioneering evidence for awareness of workplace neurodiversity in the retail industry and the impact of knowing neurodivergent employees/neurodiversity practices on benefits and challenges. It differentiates between supervisors' and co-workers’ perceptions, highlighting the importance of exposure to information in reducing stigma.
A hybrid integrated multi-criteria decision-making approach for risk assessment: a study of automotive parts industry
Authors: Chakhrit Ammar , Bougofa Mohammed , Guetarni Islam Hadj Mohamed , Bouafia Abderraouf , Kharzi Rabeh , Nehal Naima , Chennoufi Mohammed 
Published: September 2023

PurposeThis paper aims to enable the analysts of reliability and safety systems to evaluate the risk and prioritize failure modes ideally to prefer measures for reducing the risk of undesired events.Design/methodology/approachTo address the constraints considered in the conventional failure mode and effects analysis (FMEA) method for criticality assessment, the authors propose a new hybrid model combining different multi-criteria decision-making (MCDM) methods. The analytical hierarchy process (AHP) is used to construct a criticality matrix and calculate the weights of different criteria based on five criticalities: personnel, equipment, time, cost and quality. In addition, a preference ranking organization method for enrichment evaluation (PROMETHEE) method is used to improve the prioritization of the failure modes. A comparative work in which the robust data envelopment analysis (RDEA)-FMEA approach was used to evaluate the validity and effectiveness of the suggested approach and simplify the comparative analysis.FindingsThis work aims to highlight the real case study of the automotive parts industry. Using this analysis enables assessing the risk efficiently and gives an alternative ranking to that acquired by the traditional FMEA method. The obtained findings offer that combining of two multi-criteria decision approaches and integrating their outcomes allow for instilling confidence in decision-makers concerning the risk assessment and the ranking of the different failure modes.Originality/valueThis research gives encouraging outcomes concerning the risk assessment and failure modes ranking in order to reduce the frequency of occurrence and gravity of the undesired events by handling different forms of uncertainty and divergent judgments of experts.
Configurations for emerging market firms to achieve a high-level servitization strategy: evidence from Chinese manufacturing firms
Authors: Zhu Jiantao , Zhang Jun , Jiang Zhongshuang , Li Jinghua 
Published: September 2023

PurposeEmerging markets face the developmental circumstances of a weak foundation in both manufacturing and services. Although servitization is viewed as an opportunity to realise industry transformation and upgrading, ways for emerging market firms to implement a high-level servitization strategy is still understudied. This study examines combinations of causal conditions for emerging market firms to implement a high level of servitization.Design/methodology/approachAnchored in the strategy tripod model, this study examines the configurations for implementing a high-level servitization strategy by using fuzzy-set qualitative comparative analysis (fsQCA) and data from the China Stock Market and Accounting Research Database (CSMAR).FindingsThe findings identify three kinds of configurations for achieving a high-level servitization strategy: market-cultivational servitization, competition-driven servitization and government-related servitization. Furthermore, the mechanisms for implementing a high-level servitization strategy differ within the regional marketization level and state-owned equity. Specifically, the improvement of the regional marketization level helps manufacturing firms realise a high level of servitization by strengthening service capacity, and state-owned equity helps firms gain distinctive legitimacy to integrate suppliers and providers into the servitization context.Research limitations/implicationsThe proposed multilevel perspective frameworks enable manufacturing firms in emerging markets to achieve a high level of servitization strategy.Originality/valueThis paper explores the impact of institutional environment, industry conditions and firm-level microfoundations on servitization, therefore providing a reference framework for emerging market firms interested in implementing high-level servitization strategies.
New perspectives on people management dimensions in recycling startups
Authors: Adhikari Dev Raj , Shrestha Prakash , Adhikari Bibek Raj 
Published: September 2023

PurposeThis research aims to explore people management (PM) dimensions in Nepalese recycling startups (R-startups).Design/methodology/approachIt follows a case study and qualitative research approach. Information is collected from Internet searches and R-startups’ blogs. For research purposes, 12 cases out of 30 R-startups are selected using convenient and purposeful non-probability sampling methods.FindingsThree major findings are as follows: (1) the founders of R-startups have become more environmentally aware and motivated to source materials, manufacture products and deliver them without harming the environment; (2) the founders are establishing work-flow to create future employment opportunities and (3) the PM dimensions in R-startups appear to be sustainable and apparently linked with Sustainable Development Goal (SDG) 12.5, which aims to reduce waste generation substantially through prevention, reduction, recycling and reuse.Research limitations/implicationsSince researchers use widely accessible internet information, there is no possibility of interfering with the website's text and data. The analysis is solely based on the opinions of founders/co-founders of R-startups.Practical implicationsThis research presents PM dimensions in R-startups and contributes to the literature in this new field of study. Although on a small scale, this research can provide a basis for minimizing circulatory gaps and closing the loop through circular business (CB). It also provides insights into managing waste in order to create opportunities and wealth.Originality/valueThis is one of the few unexplored areas of academic research. The critical PM dimensions investigated in this study can serve as a baseline for future theoretical development in the context of a specific country.
Employee well-being: the role of perceived competence
Authors: Kultalahti Susanna , Viitala Riitta , Hujala Maija , Kekale Tauno 
Published: September 2023

Purpose
The purpose of this study is to gain more understanding of how competence might matter from the perspective of well-being at work. The authors explore how perceived competence is connected to perceived work-related well-being among Baby Boomer, Generation X and Generation Y employees.

Design/methodology/approach
The authors explore how perceived competence is connected to perceived work-related well-being among Baby Boomer, Generation X and Generation Y employees. The frames of reference of the study are based on literature on employee well-being (measured with work engagement and overcommitment) and competence, as well as on generational discussions. The quantitative, questionnaire-based study was conducted in 88 companies in Finland, with the total number of respondents being 4,418.

Findings
The main finding was that perceived competence related to current duties is statistically significantly connected to employee well-being. The results indicate that high competence results in high employee well-being in all generational groups. Further, Generation Y estimated their work well-being, both in terms of work engagement and overcommitment, lower than Baby Boomers or Generation X. The results suggest that developing competence of employees in organizations seems to be an important means to also support work well-being. It is especially important to pay attention to that among Generation Y, who take their first steps in working life. Competence is a meaningful factor for coping in working life in continually changing work environments. Incompetence is not just a factor for poor performance but also a potential threat to employee well-being.

Originality/value
Most of the competence/workplace learning results research concentrates on cognitive competence and skills, often from the employers’ benefit viewpoint (useful skills, productivity increase). This study starts from the finding that new generations of workers rather look for a meaningful work life, and thus, a feeling of having the necessary competences directly improves their well-being and, thus, life quality. Furthermore, the study is based on an original questionnaire-based study conducted in 88 companies in Finland, with the total number of respondents being 4,418.
Benefits and challenges of living in extra care housing: perspectives of people living with dementia
Authors: Atkinson Teresa , Oatley Rebecca 
Published: September 2023

Purpose
The purpose of this paper is to present the views of people living with dementia in extra care housing (ECH). This is a model of housing with care and support aiming to support older people, including those with dementia, to live independently. Previous research identifies benefits but is predominantly derived from third-party accounts, with the voices of those living with dementia in ECH significantly absent.

Design/methodology/approach
This study adopted a qualitative approach conducting 100 interviews across 8 ECH schemes in England. Over half of the interviews were conducted with people living with dementia and their families with the remainder involving staff and commissioners.

Findings
Findings suggest there are a range of benefits including owning your own home, having a safe, age friendly location with flexible support, social interaction and continuing to live as a couple. Challenges included availability of staff, flexible resourcing, loneliness and the advancing symptoms of dementia.

Research limitations/implications
Despite efforts to create an inclusive, diverse sample, the participants were all White British. Participants involved were identified by gatekeepers, which may present some bias in the selection.

Practical implications
Whilst ECH offers benefits to people living with dementia, addressing the challenges is essential for effective dementia care. Improving staff training, promoting person-centred care and fostering an inclusive community are critical for enhancing residents’ well-being and quality of life.

Originality/value
This paper explored the lived experiences of residents and family members, providing new insight into the advantages and disadvantages of ECH for people living with dementia.
Evaluating the effect of childhood sunburn on the risk of cutaneous melanoma through Mendelian randomization
Authors: Zhong Shengdong , Lan Liting , Wen Yuqing 
Published: September 2023

AbstractDespite numerous observational studies indicating an increased risk of cutaneous melanoma (CM) due to childhood sunburn, no studies have established a definitive cause‐and‐effect relationship. Therefore, our objective was to employ a Mendelian randomization (MR) design to explore a possible causal association between childhood sunburn and the risk of CM. To investigate the causal relationship between childhood sunburn and CM, we used large‐scale genetic summary‐level data from genome‐wide association studies (GWAS), including childhood sunburn (n = 346,955) and CM (n = 262,288), building upon previous observational studies. In the analysis, we mainly used the inverse‐variance weighted (IVW) method of the random effects model, supplemented by the weighted median method and MR‐Egger method. The results of the IVW method demonstrated that genetically predicted childhood sunburn was significantly associated with higher odds of CM, with an odds ratio (OR) of 2.418 (95%CI, 1.426–4.099; p = .001). The weighted median method and MR‐Egger regression also demonstrated directionally similar results (both p < .05). Furthermore, both the funnel plot and the MR‐Egger intercepts showed the absence of directional pleiotropy between childhood sunburn and CM. Our study offers potential evidence linking genetically predicted childhood sunburn with CM, underscoring the need for individuals with a history of childhood sunburn to be extra vigilant regarding the occurrence of CM.
Caregiver education programme on intellectual and developmental disabilities: An acceptability and feasibility study in an academic medical setting
Authors: Stone‐Heaberlin Meg , Blackburn Allison , Qian Cheng 
Published: September 2023

AbstractBackgroundChildren and adolescents with intellectual and developmental disabilities (I/DD), including autism spectrum disorder, benefit from a variety of specialized interventions. However, there are barriers that impact families' ability to access such services for their children. While not intended as a replacement for individualized or group‐based interventions, educational classes may be an option in providing supplemental resources and support to families of individuals with I/DD. This study was a programme evaluation that examined the feasibility and acceptability of a Caregiver Education Program that was created in an outpatient specialty clinic of an academic medical centre, designed to provide educational information on a variety of topics relevant to children and adolescents with I/DD (e.g., toilet training, understanding behaviour and managing anxiety).MethodThe review included 1027 participants from 40 classes led by licensed clinicians, trainees, and/or experienced caregivers. Classes occurred approximately one time per month over the course of three‐and‐a‐half years and targeted caregivers of children and adolescents with I/DD and community‐based professionals in the field of I/DD. Participants were able to attend one or multiple classes, based on their interest in the given topic. Participants were asked to complete post‐training surveys at the end of each session as part of ongoing programme evaluation.ResultsParticipants reported a high level of satisfaction and increased knowledge as a result of participating in classes, and higher knowledge gained and higher satisfaction for in‐person classes compared to virtual classes.ConclusionsThis programme is one model of education delivery with high acceptability and feasibility, designed to support families and increase access to information beyond specialized interventions. Future directions include improving the model of programme data collection, examination of the programme's generalization to practice and to other communities, and an emphasis on culturally responsive curricula.
Neutral polysaccharide from Gastrodia elata alleviates cerebral ischemia–reperfusion injury by inhibiting ferroptosis‐mediated neuroinflammation via the NRF2/HO‐1 signaling pathway
Authors: Zhang Yonggang , Ye Peng , Zhu Hua , Gu Lijuan , Li Yuntao , Feng Shi , Zeng Zhi , Chen Qianxue , Zhou Benhong , Xiong Xiaoxing 
Published: September 2023

AbstractAimsThe crosstalk between ferroptosis and neuroinflammation considerably impacts the pathogenesis of cerebral ischemia–reperfusion injury (CIRI). Neutral polysaccharide from Gastrodia elata (NPGE) has shown significant effects against oxidative stress and inflammation. This study investigated the potential effects of NPGE on CIRI neuropathology.MethodsThe effects of NPGE were studied in a mouse model of ischemic stroke (IS) and in oxygen–glucose deprivation/reperfusion (OGD/R)‐induced HT22 cells.ResultsNPGE treatment decreased neurological deficits, reduced infarct volume, and alleviated cerebral edema in IS mice, and promoted the survival of OGD/R‐induced HT22 cells. Mechanistically, NPGE treatment alleviated neuronal ferroptosis by upregulating GPX4 levels, lowering reactive oxygen species (ROS), malondialdehyde (MDA), and Fe2+ excessive hoarding, and meliorating GSH levels and SOD activity. Additionally, it inhibited neuroinflammation by down‐regulating the level of IL‐1β, IL‐6, TNF‐α, NLRP3, and HMGB1. Meanwhile, NPGE treatment alleviated ferroptosis and inflammation in erastin‐stimulated HT22 cells. Furthermore, NPGE up‐regulated the expression of NRF2 and HO‐1 and promoted the translocation of NRF2 into the nucleus. Using the NRF2 inhibitor brusatol, we verified that NRF2/HO‐1 signaling mediated the anti‐ferroptotic and anti‐inflammatory properties of NPGE.ConclusionCollectively, our results demonstrate the protective effects of NPGE and highlight its therapeutic potential as a drug component for CIRI treatment.
Clinical and oncological outcomes of pelvic exenteration surgery for anal squamous cell carcinoma
Authors: Quyn Aaron J. , Murthy Shilpa , Gould Laura , Said Hager , Tiernan Jim , Sagar Peter , Antoniou Anthony , Jenkins Ian , Burns Elaine M. 
Published: September 2023

AbstractAimAnal cancer incidence and mortality rates are rising in the United Kingdom (UK). Surgery is an important treatment modality for persistent or recurrent disease. There is a paucity of data on outcomes for patients undergoing pelvic exenteration for anal squamous cell carcinoma (SCC) for persistent or recurrent disease. The aim of this study was to investigate the outcomes for patients who were treated with pelvic exenteration for anal SCC from two high‐volume, high‐complexity pelvic exenteration units in the UK.MethodA retrospective review of prospectively maintained databases from 2011 to 2020 was undertaken. Primary endpoints included R0 resection rates, overall and disease‐free survival at 2 and 5 years.ResultsFrom 2011 to 2020, 35 patients with anal SCC were selected for exenteration. An R0 resection was achieved in 26 patients (77%). Of the remaining patients, seven patients had an R1 resection and one had a R2 resection. One further patient was excluded from additional analysis as the disease was inoperable at the time of laparotomy. With a median follow‐up of 19.5 months (interquartile range 7.9–53.5 months), overall survival was 50% (17/34). Patients with an R1/2 resection had a significantly poorer overall survival [0.27 (0.09–0.76), p = 0.021] than those patients in whom R0 resection was achieved. Disease‐free survival was 38.2% (13/34) and an R1/R2 resection was associated with a significantly reduced disease‐free survival [0.12 (0.04–0.36), p < 0.001].ConclusionComplete R0 resection for recurrent or persistent anal SCC is possible in the majority of patients and improves overall and disease‐free survival compared with R1/R2 resection.