bluuebunny/crossref_metadata_2025_split huggingface dataset:
The dynamics of the El Niño Southern Oscillation diversity in the Recharge Oscillator framework
Authors: Priya Priyamvada , Dommenget Dietmar , McGregor Shayne 
Published: September 2023

Abstract
This study investigates the observed El Niño Southern Oscillation (ENSO) dynamics for the eastern Pacific (EP) and central Pacific (CP) events in reference to the canonical ENSO (T). We use the recharge oscillator (ReOsc) model concept to describe the ENSO phase space, based on the interaction of sea surface temperature (T) and thermocline depth (h), for the different types of ENSO events. We further look at some important statistical characteristics, such as power spectrum and cross-correlation, as essential parameters for understanding the dynamics of ENSO. The results show that the dynamics of the CP and EP events are very different from each other and from the canonical ENSO events. The canonical ENSO (T) events fit closest to the idealised ReOsc model and has the most clearly oscillating ENSO phase space, suggesting it is the most predictable ENSO index. The EP index is similar to the canonical ENSO, but the phase space transitions are less clear, suggesting less of an oscillatory nature and the index is more focussed on extreme El Niño and discharge states. The CP index, in turn, does not have a clear propagation through all phases and are strongly skewed towards the La Niña state. The interaction between CP and h are much weaker, making the mode less predictable. Wind forced shallow water model simulations show that the CP winds do not force significant h tendencies, strongly reducing the delayed negative feedback, which is essential for the ENSO cycle.
Protein profiling in systemic sclerosis patients with different pulmonary complications using proteomic antibody microarray
Authors: Huang Jing , Zhu Honglin , Liu Sijia , Li Mengtao , Li Yisha , Luo Hui , Zuo Xiaoxia 
Published: September 2023

Abstract
Background: Pulmonary arterial hypertension (PAH) and interstitial lung disease (ILD) are leading causes of systemic sclerosis (SSc) -related death. In this study, we aimed to identify biomarkers for detecting SSc pulmonary complications that are mild and in the early stages to improve the prognosis.
Methods: We screened for serum biomarkers using a proteomic antibody microarray that simultaneously assessed 1,000 proteins. Differentially expressed proteins were further verified using ELISA. Finally, we performed a correlation analysis using clinical data.
Results: We identified 125 differentially expressed proteins, of which calcitonin, sclerostin (SOST), CD40, and fibronectin were selected for further verification. Serum calcitonin and SOST levels were significantly elevated in all SSc pulmonary complication subgroups, whereas serum calcitonin levels were higher in the SSc with PAH subgroup than in the SSc without PAH and ILD subgroup. Serum SOST levels were possibly associated with the presence of ILD and positively related to the presence of cardiac and gastrointestinal involvement. Serum CD40 and calcitonin levels appeared to be positively related to the presence of renal involvement, and serum calcitonin was also positively related to the presence of gastrointestinal involvement.
Conclusions: This study indicated that serum calcitonin and SOST levels may be promising biomarkers for SSc-related PAH and ILD, respectively. Further research is needed to verify this result and understand the underlying mechanisms.
Impact of aquaculture practices on the sustainability of social-ecological systems in coastal zones of the Mekong delta
Authors: Hua Hieu Hong , Cremin Emilie , Huynh Van Da , Long Graham , Renaud Fabrice 
Published: September 2023

Abstract
Historically, local communities have thrived in the coastal zones of the Mekong Delta in Vietnam, characterised by diverse habitats such as mangroves, marshes, and mudflats, harbouring significant biodiversity. However, escalating global market demands and price fluctuations have driven the adoption of more intensive aquaculture models, generating new threats to these vulnerable areas. Consequently, coastal regions face compounded hazards (high temperatures, drought, floods, high tides, sea level rise, and saline intrusion), necessitating the identification of socio-economic and ecological drivers of risks to sustainable livelihoods centred around shrimp aquaculture. This research aims to comprehend the impact of various shrimp farming models, ranging from extensive to hyper-intensive, in the context of multiple natural hazards and transformative processes like land conversion and mangrove restoration. By employing risk assessment tools and analysing qualitative and quantitative data gathered from interviews and focus groups with local communities and stakeholders, we present a comprehensive model illustrating the influence of different aquaculture models on coastal socio-ecological systems. Key findings emphasise the interplay between livelihoods, landscape conversion to shrimp farming, and factors guiding such conversions. The paper highlights how these diverse aquaculture models can augment or diminish risks to sustainable livelihoods in the Mekong Delta. It outlines the benefits, constraints, and potential hazards associated with each model and stresses the need for stakeholder collaboration to preserve vital ecosystems and their services. Additionally, the study underlines the importance of improved wastewater treatment practices among farming units to benefit neighbouring farmers and foster overall environmental well-being.
Chitosan functionalized iron oxide nanocomposites as a novel carbonic anhydrase nano-inhibitor
Authors: Mostafa Samar M. , Fathy Mohamed M. , Khalil Wafaa M. , Mohamed Noha 
Published: September 2023

Abstract

This study evaluates the interaction between different molecular weight chitosan functionalized iron oxide nanoparticles (INPs) and carbonic anhydrase II (CAII) as a new approach for the inhibition of CAII. INPs functionalized with different molecular weight chitosan (HC-INPs, MC-INPs, LC-INPs). The characterizations of the synthesized nanocomposites were performed using TEM, XRD, Zeta potential, FTIR, and VSM. The interaction of nanocomposites with CAII was also assessed. The average diameters of prepared nano-formulations were approximate, 4 nm, 11.5 nm, and 20 nm for HC-INPs, MC-INPs, and LC-INPs respectively. Zeta potential values were 39.2 ± 3.9 mV, 36.7 ± 4.1 mV, and 15.5 ± 4.6 mV for HC-INPs, MC-INPs, and LC-INPs respectively. Fluorescence quenching assays and Enzyme Kinetics activity results revealed that the CAII-nanocomposites interaction led to CAII conformational changes that rendered the enzyme inactive. Interestingly, we found that the surface property of nano-inhibitors plays a vital role in their inhibition ability. Whereas HC-INPs have the most potent inhibitory effect with Ki (ng/ml) = 58.388 (ng/ml). While MC-INPs and LC-INPs have Ki=390.87 (ng/ml) and 1213.00 (ng/ml), respectively. The prepared chitosan functionalized iron oxide nanoparticles (especially HC-INPs) are considered a novel nano-inhibitor for CAII which pave the way for using HC-INPs to target disorders related to CAII overexpression.
Thermal evaluation and optimization of a building heating system : radiant floor coupled with a solar system
Authors: Simou Z. , Hamdaoui S. , Oubenmoh S. , Afou Y. El , Babaharra O. , Mahdaoui M. , Msaad A. Ait 
Published: September 2023

Abstract
The continuous increase in the building energy consumption impactes negatively on both energy resources and the environment. In this respect, the use of conventional heating systems affects on both energy consumption and the related co2 emissions. The present work shows the benefits of using a radiant floor heating system (RFHS) coupled with a solar energy system. In the current study TRNSYS-18 software was used to numerically evaluate the RFHS. To achieve improved efficiency and optimize the performance of this letter, a parametric study was conducted on the solar system characteristics and the heated floor. According to the obtained results the optimal design parameters of the system that lead to a high annual solar fraction (SF=93.72%) are: a parabolic trough collector area of 6 m2 with a tilt angle 60°, a mass flow rate of 180 kg/h and 410 kg for the collector and floor heating respectively, and a thickness of 0.07m for the heating floor slab. Furthermore, the total auxiliary energy consumption of the RFHS is approximately 63.42 kWh, versus 1953.41 kWh for a conventional heating system of reference. The economic results of the studied system show that the cost of energy saving is 244.25 €/year, and becomes 257.52 €/year with the production of solar domestic hot water. The payback period is estimated at around 13 years.
Revolutionizing Teamwork and Engagement in the Operating Room: AI-Driven Patient Case Narration for Enhanced OR Timeouts
Authors: Khalpey Zain , Kumar Ujjawal , Rozell Brynne , Kramer Scott , Evans Joel , Khalpey Amina 
Published: September 2023

Abstract

Background
Surgical errors are a significant cause of morbidity and mortality in the operating room as well as financial burden. The surgical timeout is a crucial step in reducing such errors, though it is often carried out ineffectively and can be unengaging, with quality and efficacy limited by human factors. The development and implementation of digital technologies such as artificial intelligence and machine learning provides untapped potential to improve surgical timeouts.
Methods
Avoice-integrated system was developed in conjunction with a leading voice-enablement company, and eight surgical timeouts were performed using this system in cardiothoracic procedures. The Khalpey Artificial Intelligence system consisted of an Android device running KAI Voice at the center of the operating room, taking in vocal input, processing using an independent database and recording for storage/integration into EHR and other systems. A questionnaire was administered to all members of the multidisciplinary surgical team and responses were used to assess key stakeholder opinions.
Results
Feedback was overwhelmingly positive; team members found it to be more engaging and beneficial to operative flow and teamwork. Strengths were noted to be its improvement of compliance, prevention of surgical errors, and increased awareness of specific procedural details by members of the surgical team. Despite timeout length itself increasing slightly, this did not increase the operative procedure length due to the increases in workflow efficiency intraoperatively.
Conclusions
Our study shows there to be merit in the use of AI technologies to enhance surgical processes such as the timeout, with the ultimate result of improving patient outcomes and healthcare system efficiency.
Primary mediastinal seminoma with chronic granulomatous inflammation and lymphoid follicular hyperplasia: A case report and literature review
Authors: Luo Siyi , Zhang Weishan , Luo Qichi , Wang Guowu 
Published: September 2023

Abstract
Background: In this paper, a 22-year-old male patient with primary mediastinal seminoma (PMS), a rare extragonadal germ cell tumor, was described. Due to chest pain, this patient was admitted to the hospital and received the thoracic contrast-enhanced CT and further magnetic resonance imaging (MRI) examination, with the result of a mass in the anterior mediastinum, which indicated a benign tumor or tumor-like lesion such as thymic or thymomas. After the testicular metastasis was excluded after surgery, he was pathologically diagnosed with PMS, accompanied by secondary histological features, including a dense inflammatory infiltrate comprising a combination of lymphocytes and granulomatous inflammation that may obscure the underlying neoplasm, thus leading to missed diagnosis or misdiagnosis or delayed diagnosis. Therefore, a proper understanding of the histological features and rare accompanying features of this disease is essential for the correct diagnosis and postoperative treatment.
Design of a multi-epitope vaccine candidate of gastric cancer against Helicobacter pylori
Authors: Shojaeian Ali , Sanami Samira , Mahmoudvand Shahab , Amini Razieh , Alibakhshi Abbas 
Published: September 2023

Abstract
Background: Gastric cancer and peptic ulcers can both be caused by Helicobacter pylori (H. pylori). So the complexity of such bacterium made it difficult to develop an effective treatment. Thus, a computational approach to developing antigenicity, stability, and safety in vaccines against this pathogen will aid in the management of related diseases.
Methods: This investigation chose two H. pylori proteins, SabA and BabA, as epitope prediction targets. Therefore, this study used an immunoinformatics platform to create a subunit vaccine against H. pylori. The best helper T lymphocytes (HTLs) along with cytotoxic T lymphocytes (CTLs) epitopes have been chosen according to antigenicity, toxicity and allergenicity. The chosen epitopes, suitable linkers, as well as adjuvants were combined for creating a final vaccine design. The antigenicity, allergenicity, along with physicochemical traits of vaccine were assessed.
Results: The vaccine’s 3D structure has been anticipated. Molecular docking analysis along with molecular dynamics (MD) simulation were performed on multi-epitope vaccine. The vaccine candidate was in silico cloned in pET28a (+) vector.
Conclusion: The results showed that final vaccine design would work well as an effective prophylactic vaccine versus H. pylori. To evaluate vaccine efficacy against the aforementioned bacteria, in vivo and in vitro trials are required.
Education spread and economic development: Portugal 1981
Authors: Pontes José Pedro 
Published: September 2023

Abstract

We try to rationalize the fact that the impact of higher education spread on aggregate productivity tends to disappear as a higher share people completes college. For that purpose, we model this situation by means of a coordination (Stag Hunt) game, where a youngster reaps the benefit of higher education only if there is a critical mass of students.
During the initial stage the net reward of higher education is high, so that the Nash equilibrium with general enrolment is selected. As higher education becomes widespread, its relative benefit tends to decline because the relative wage of skilled labour falls with the rise in its supply and universities face diseconomies of scale as they expand over lower density territories.
The decrease in the reward is multiplied by the fact that the strategy of avoiding higher education becomes “risk-dominant”, which more likely leads to a coordination breakdown, where the tertiary schooling rate might rise despite the output per worker decreases.
This socially undesirable outcome can be avoided through a policy aimed at college network enhancement through its geographical concentration. For this purpose, the relocation of a significant share of students appears to be necessary.
JEL codes: C72, I25, 015, R11
POLÍTICAS PÚBLICAS PARA LA RESOCIALIZACIÓN E INTEGRACIÓN SOCIAL DE LOS DESMOVILIZADOS DEL CONFLICTO ARMADO INTERNO EN COLOMBIA
Authors: Caro Madrid Adonis , Vélez Vega Leonor 
Published: September 2023

En el presente arti?culo de investigacio?n se presentan los resultados de una investigacio?n titulada Poli?ticas pu?blicas sobre resocializacio?n e integracio?n social de los desmovilizados del conflicto armado interno en Colombia, donde se analizo? que el problema de la delincuencia emergente, producto del surgimiento de las bandas criminales, tiene su origen en la desmovilizacio?n de los grupos armados al margen de la ley, las denominadas BACRIM, que son los remanentes de los grupos paramilitares y algunos eje?rcitos privados de extintos carteles del narcotra?fico, cuya violencia y propagacio?n del delito paso? de los campos rurales a los cascos urbanos, evolucionando hacia una nueva forma de delincuencia organizada estructurada y compleja, en bu?squeda de fortalecer su existencia e influencia en la ya establecida delincuencia que hace parte de Colombia. El presente trabajo analiza la historia de la delincuencia organizada en los u?ltimos an?os de la nacio?n, estableciendo una analogi?a entre los institutos de poli?tica criminal que procuran combatir y disminuir los actos violentos de esta nueva ola de delito, y estudiando el origen de dichas organizaciones delictivas, analizando el papel del derecho estatal y las poli?ticas ofi- ciales, para prevenir el alzamiento de grupos al margen de la ley, en este nuevo feno?meno de crimen organizado.
Palabras clave: BACRIM, Poli?tica criminal, Delincuencia organizada, Poli?ticas pu?blicas estatales, Justicia y paz, Criminologi?a, Prevencio?n del delito.
Abstract

This research develops a jurisprudential analysis of Public policies on social rehabilitation and social integration of demobilized the armed conflict in Colombia, which, we make in order to get our title specialists in Criminal Law and Criminology. The problem of crime emerging product of the rise of criminal gangs, has its origin in the demobilization of armed groups outside the law, called the BACRIM are remnants of paramilitary groups and some private armies of drug cartels extinct, whose violence and spread of crime over the rural areas to the urban centers, evolving into a new form of structured and complex organized crime, seeking to strengthen its presence and influence in the established crime that is part of the Colombian nation. This paper analyzes the history of organized crime in the last years of the nation, drawing an analogy between criminal policy institutes working to combat and reduce the violence of this new wave of crime, and studying the origin of such organizations crime, analyzing the role of state law and public policy, to prevent the rise of groups outside the law, in this new phenomenon of organized crime.
Keywords: BACRIM, Criminal policy, Organized delinquency, Official public policies, Justice and peace, Criminology, Crime prevention.
PARTICIPACIO?N POLI?TICA Y VIOLENCIA DE GE?NERO EN AME?RICA LATINA
Authors: Albaine Laura 
Published: September 2023

Este arti?culo reflexiona a trave?s del ana?lisis de factores socioculturales e institucionales sobre uno de los obsta?culos ma?s graves que condicionan la participacio?n poli?tica de las mujeres en Ame?rica Latina: El acoso y violencia poli?tica en razo?n de ge?nero. Esta problema?tica es una nueva expresio?n que ha adoptado la violencia de ge?nero en la arena poli?tica que restringe el ejercicio de los derechos poli?ticos de las mujeres y el derecho a vivir una vida libre de violencia.
El acoso y violencia poli?tica se manifiesta ma?s alla? de los avances normativos logrados en la regio?n orientados a generar condiciones de igualdad en te?rminos de ge?nero en la participacio?n poli?tica. En consecuencia, a las normas que promueven el acceso de las mujeres a cargos de decisio?n, tales como cuotas o paridad, deben suma?rsele cuerpos legales que garanticen, adema?s de sus derechos poli?ticos, su seguridad y sus derechos humanos.
Abstract
This paper focuses on a reflection and analysis of socio-cultural and institutional factors that affect women’s political participation in Latin America, such as gender-based harassment and violence. This problem is a new expression that has adopted gender-based violence in the political arena, restricting not only the exercise of women’s political rights but also their right to live a life free of violence.
Despite Latin American countries have enacted laws to create conditions in terms of gender equality in political participation, political harassment and violence still occurs. However, these policy actions are not enough to ensure women’s access to decision-making positions, such as quotas or parity; it must also be legal bodies to ensure, in addition to their political rights, their personal safety, and human rights.
Associations among computed tomographic measures of bone and muscle quality and biomechanical measures of tibiotarsal bone quality in laying hens
Authors: Harrison Cerano , Jones Jeryl , Bridges William , Anderson Gracie , Ali Ahmed , Mercuri Jeremy 
Published: September 2023

Abstract

OBJECTIVE
The objectives of the current study were to quantify laying hen sternal carina (keel) and tibiotarsal bone and muscle quality using clinical CT, tissue level, and biomechanical measures; test associations among muscle transverse sectional area, bone mineral density, and biomechanical measures of bone quality; and determine whether CT measures of bone and muscle quality would be predictive of biomechanical measures of tibiotarsal bone quality.

ANIMALS
60 40-week-old Hy-Line brown laying hens were used.

METHODS
Associations among CT imaging, tissue level, and biomechanical measures of tibiotarsal and keel bone and muscle quality were tested using multivariate correlational analyses. Bivariate and generalized regressions were performed to determine whether CT measures were predictive of biomechanical measures of tibiotarsal bone quality.

RESULTS
Low positive correlations were identified between tibiotarsal muscle transverse-sectional area (cross-sectional area [CSA]) and bone mineral density (BMD) in the proximal location of the bone (r = −0.11 to 0.31). Tibiotarsal muscle CSA was also low to moderately correlated with biomechanical measures of bone quality (r = 0.20 to 0.41). Keel muscle CSA values were not correlated with keel BMD values, but they were correlated with biomechanical measures of tibiotarsal bone quality (r = 0.18 to 0.40). Keel CT measures of bone quality were not correlated with tibiotarsal CT measures of bone quality. At the proximal location, muscle CSA and tibiotarsal BMD were predictive of biomechanical failure load (F = 9.68, P = .0003muscle CSA; F = 9.13, P = .004tibiotarsal BMD).

CLINICAL RELEVANCE
Findings supported using noninvasive CT measures of muscle and bone quality in longitudinal research studies evaluating the effects of interventions on laying hen welfare.
The application of big data technology in the integration of non-foreign heritage into the construction of college sports curriculum thinking and politics
Authors: Li Dan , Han Liu 
Published: September 2023

Abstract
This paper firstly takes the non-heritage Taijiquan course SiM to the physical education course SiM as the theoretical starting point to enrich and expand the theoretical connotation of the physical education course SiM. Secondly, a sorting algorithm is used to sort the recall set by the interaction data of students and the physical education curriculum Civics elements to determine the final display order of the recall elements. A ranking model incorporating students’ long-term and short-term behaviors is proposed to model the sequence of students’ long-term and short-term behaviors separately. Finally, the long-term behavioral features of students are extracted using the self-attention mechanism, and the short-term behaviors of students and the extracted long-term behavioral features are modeled in sequences by GRU units, respectively, to explore the interesting Civics elements of students fully. The results show that the initial eigenvalues of the public factors 1-5 of the integration of non-heritage Taijiquan culture into the thought politics construction of college physical education courses are all greater than 1, which meets the factor extraction criteria. At the same time, the cumulative variance values of the five public factors of the Civic and Political elements can explain 88.378% of the whole index, which meets the criteria of exploratory factor analysis. In this paper, the integration of non-heritage Taijiquan into the construction of Civic college's physical education curriculum provides the enlightenment of the times for the re-conceptualization of traditional Chinese culture and realizes the collaborative team innovation with cross-border integration.