bluuebunny/crossref_metadata_2025_split huggingface dataset:
HAK ASASI MANUSIA DALAM PANDANGAN ISLAM
Authors: Pitriani Pitriani 
Published: March 2023

Normally, the position of the human person with all the rights of the most fundamental has gained recognition in the Declaration and the International Covenants. Human rights have become values and norms in international relations. This is shown by the agreement of all countries, at least in countries that are members of the United Nations to the United Nations Charter, the Universal Declaration of Human Rights (1948). Islam as a religion and its teachings are universal and comprehensive, encompassing faith, worship, and mu'amalat, each of which contains the doctrine of the faith; religious dimension to the teachings of the mechanisms of human devotion to God; with either the doctrine of man's relationship with fellow humans and to the environment. Each dimension is based on the teachings of the provisions referred to by the term Sharia or Islamic jurisprudence. In the context of law or jurisprudence there are teachings on Human Rights (HAM). The existence of the doctrine of human rights in Islam shows that Islam as a religion has placed man as honorable and noble creatures. Therefore, the protection and respect for the human being is the claim of Islam itself must be carried out by Muslims against fellow human beings without exception.Secara normatif, kedudukan pribadi manusia dengan segala hak-haknya yang paling asasi telah memperoleh pengakuan dalam Deklarasi dan Kovenan-kovenan internasional. Hak-hak asasi manusia telah menjadi nilai dan norma dalam hubungan internasional. Hal ini ditunjukkan oleh persetujuan semua negara, setidak-tidaknya negara-negara yang menjadi anggota PBB terhadap piagam PBB, Deklarasi Universal tentang Hak-Hak Asasi Manusia (1948).Islam sebagai sebuah agama dengan ajarannya yang universal dan komprehensif meliputi akidah, ibadah, dan mu’amalat, yang masing-masing memuat ajaran tentang keimanan; dimensi ibadah memuat ajaran tentang mekanisme pengabdian manusia terhadap Allah; dengan memuat ajaran tentang hubungan manusia dengan sesama manusia maupun dengan alam sekitar. Kesemua demensi ajaran tersebut dilandasi oleh ketentuan-ketentuan yang disebut dengan istilah syari’ah atau fikih.Dalam konteks syari’at atau fikih itulah terdapat ajaran tentang Hak Asasi Manusia (HAM).Adanya ajaran tentang HAM dalam Islam menunjukkan bahwa Islam sebagai agama telah menempatkan manusia sebagai makhluk terhormat dan mulia.Karena itu, perlindungan dan penghormatan terhadap manusia merupakan tuntutan dari ajaran Islam itu sendiri yang wajib dilaksanakan oleh umatnya terhadap sesama manusia tanpa kecuali.
Severity of Symptoms and Mortality in Diabetic Patients with COVID- 19 Infection. Review
Authors: Zahraa ALBasry  , Abeer Abdulhadi Rashid  , Shaymaa Hasan Abbas  
Published: March 2023

Background: COVID-19 pneumonia is an illness that was spreading rapidly around the world and causes many deaths. Diabetes, is considered as a risk factor which adds severity and mortality to COVID-19 infected persons. There are many studies aiming to explain the
exact association between diabetes and COVID-19. This review aims to link between diabetes and COVID-19 risk factors, discuss the management of patients with diabetes and COVID-19 and provide perception into the COVID-19 disease complications relevant to diabetes .In this review, many scientific articles and reports about COVID- 19 and Type 2 DM were collected from different databases (e.g., PubMed, Google Scholar, and Web of Science) using keywords such as SARS-CoV2, COVID-19, TYPE 2 DM, Mortality, and CO-morbidities .The result from this study found that diabetic patients has poor prognosis, severe symptoms, worsen outcomes, and the mortality rate is higher among COVID-19 patients who have diabetes mellitus. Many complications associated with diabetes like peripheral neuropathy and vascular insufficiency can make patients more susceptible to infections. One of the sever complication of Covid-19 infection is, the cytokine storm, that result in excessive release of inflammatory cytokines (TNF-a, IL-6, IL-10), and this may be aggravated by the inflammatory process together with the hyper-coagulable condition in diabetic patients. In conclusion: Hyperglycemia is established as risk factor for increased morbidity and mortality in covid 19 infection.
Costo en la implementación de la norma internacional de información financiera de impuesto a las ganancias en las PYMEs
Authors: Paredes Cruz Renato Estuardo , Vasconez Fuentes Jose Luis , Castellano Montiel Alberto Gregorio , Tanqueño Colcha Oscar Paul 
Published: March 2023

Introducción: Las Normas Internacionales de Información Financiera fueron concebidas como estándares de general aplicación para todo tipo de empresas; consecuentemente su aplicación inicia con las grandes organizaciones que negociaban en la bolsa de valores, por cuanto se urgía tener información comparable internacionalmente como sustento a la toma de decisiones. Objetivos: es determinar el costo en la aplicación de la normativa NIIF para PYMEs específicamente de los impuestos diferidos ya que alrededor de 18 países en el mundo han decidido no adoptar esta normativa. Metodología: Se utilizó para el desarrollo de la presente investigación la investigación descriptiva cual permite presentar un punto de vista sobre un tema en particular proporcionando argumentos y evidencias de la revisión bibliográfica realizada. Resultados: Al tratar de implementar la Normativa contable a las PYMEs resulto ser demasiado compleja debido a que estas no contaban con recursos materiales, tecnológicos y humanos suficientes e incluso era debatible el beneficio en la aplicación de ciertas normas. Conclusiones: Hay países que se niegan a implementar las NIFF para PYMES por considerarlas incompletas sin embargo según el paradigma de la utilidad se debería representar en el estado financiera solo información que sirva para la toma de decisiones. Área de estudio: Administración
IS IT TRANSPARENT AND ACCOUNTABLE, OR JUST STEAL THE PUBLIC ATTENTION?
Authors: Ginting Rafles 
Published: March 2023

This study aims to find out how the implementation of transparency carried out by schools related to financial reporting and BOS funds to third parties and to analyse how the accounting system applied to school financial reporting and BOS Funds is compared to the provisions in accordance with Statement of Financial Accounting Standards (ISAK) 35 and technical guidelines related to BOS Funds imposed by the Ministry of Education, Culture, Research, and Technology. In this study, researchers conducted an analysis by collecting data, compiling it. interpret and analyse the data to produce research conclusions. This type of research is descriptive qualitative research through centralized interviews with informants to obtain accurate and relevant data. The results of this study show that the reporting of the school BOS Fund has been carried out, but the financial statements made by the school are still not in accordance with ISAK 35
MANAJEMEN PEMERINTAHAN DALAM INOVASI PELAYANAN PENGADUAN MASYARAKAT DI KABUPATEN KARAWANG (STUDI PADA APLIKASI TANGGAP KARAWANG ATAU TANGKAR)
Authors: Anggrayni Irena 
Published: March 2023

Penelitian ini bertujuan untuk mengetahui bagaimana manajemen pemerintahan dalam aplikasi pengaduan masyarakat oleh Pemerintah Kabupaten Karawang berupa pembuatan aplikasi TANGKAR dalam mengorganisasi dan menyelesaikan pengaduan dari masyarakat Karawang. Penelitian ini menggunakan metode penelitian deskriptif kualitatif yang didasarkan pada teori manajemen yang dikemukakan oleh George R Terry yang ditinjau oleh beberapa aspek seperti: perencanaan, pengorganisasian, pelaksanaan, dan pengawasan. Metode yang digunakan adalah menggunakan metode deskriptif dengan pendekatan kualitatif, yang bersifat naratif. Sumber data yang diperoleh yaitu berupa data primer yang berasal dari informan secara langsung dan data sekunder berasal dari data-data pendukung lainnya. Penelitian ini dilakukan dengan cara observasi secara langsung, wawancara yang mendalam kepada narasumber dan instrumen pendukung yang diperkuat dengan adanya dokumentasi, dan didukung oleh data sekunder yang ada. Hasil penelitian menunjukan bahwa manajemen aplikasi ini cukup baik dan aplikasinya cukup bermanfaat dalam menangani berbagai pengaduan yang diberikan dan di bagikan di media sosialnamun ada beberapa hal yang menjadi sebuah evaluasi dan perbaikan bagi aplikasinya yaitu berupa admin yang harus diperbanyak, aplikasi yang butuh perawatan lanjutan agar tidak sering terjadinya error.
Kata Kunci: Manajemen, Pengaduan Masyarakat, TANGKAR
Trabecular bone remodeling in the aging mouse: A micro-multiphysics agent-based in silico model using single-cell mechanomics
Authors: Boaretti Daniele , Marques Francisco C. , Ledoux Charles , Singh Amit , Kendall Jack J. , Wehrle Esther , Kuhn Gisela A. , Bansod Yogesh D. , Schulte Friederike A. , Müller Ralph 
Published: March 2023

Bone remodeling is regulated by the interaction between different cells and tissues across many spatial and temporal scales. Notably, in silico models are regarded as powerful tools to further understand the signaling pathways that regulate this intricate spatial cellular interplay. To this end, we have established a 3D multiscale micro-multiphysics agent-based (micro-MPA) in silico model of trabecular bone remodeling using longitudinal in vivo data from the sixth caudal vertebra (CV6) of PolgA(D257A/D257A) mice, a mouse model of premature aging. Our in silico model includes a variety of cells as single agents and receptor-ligand kinetics, mechanomics, diffusion and decay of cytokines which regulate the cells’ behavior. We highlighted its capabilities by simulating trabecular bone remodeling in the CV6 of five mice over 4 weeks and we evaluated the static and dynamic morphometry of the trabecular bone microarchitecture. Based on the progression of the average trabecular bone volume fraction (BV/TV), we identified a configuration of the model parameters to simulate homeostatic trabecular bone remodeling, here named basal. Crucially, we also produced anabolic, anti-anabolic, catabolic and anti-catabolic responses with an increase or decrease by one standard deviation in the levels of osteoprotegerin (OPG), receptor activator of nuclear factor kB ligand (RANKL), and sclerostin (Scl) produced by the osteocytes. Our results showed that changes in the levels of OPG and RANKL were positively and negatively correlated with the BV/TV values after 4 weeks in comparison to basal levels, respectively. Conversely, changes in Scl levels produced small fluctuations in BV/TV in comparison to the basal state. From these results, Scl was deemed to be the main driver of equilibrium while RANKL and OPG were shown to be involved in changes in bone volume fraction with potential relevance for age-related bone features. Ultimately, this micro-MPA model provides valuable insights into how cells respond to their local mechanical environment and can help to identify critical pathways affected by degenerative conditions and ageing.
Iodide uptake by forest soils is principally related to the activity of extracellular oxidases
Authors: Grandbois Russell M. , Santschi Peter H. , Xu Chen , Mitchell Joshua M. , Kaplan Daniel I. , Yeager Chris M. 
Published: March 2023

129I is a nuclear fission decay product of concern because of its long half-life (16 Ma) and propensity to bioaccumulate. Microorganisms impact iodine mobility in soil systems by promoting iodination (covalent binding) of soil organic matter through processes that are not fully understood. Here, we examined iodide uptake by soils collected at two depths (0–10 and 10–20 cm) from 5 deciduous and coniferous forests in Japan and the United States. Autoclaved soils, and soils amended with an enzyme inhibitor (sodium azide) or an antibacterial agent (bronopol), bound significantly less 125I tracer (93%, 81%, 61% decrease, respectively) than the untreated control soils, confirming a microbial role in soil iodide uptake. Correlation analyses identified the strongest significant correlation between 125I uptake and three explanatory variables, actinobacteria soil biomass (p = 6.04E-04, 1.35E-02 for Kendall-Tau and regression analysis, respectively), soil nitrogen content (p = 4.86E-04, 4.24E-03), and soil oxidase enzyme activity at pH 7.0 using the substrate L-DOPA (p = 2.83E-03, 4.33E-04) and at pH 5.5 using the ABTS (p = 5.09E-03, 3.14E-03). Together, the results suggest that extracellular oxidases, primarily of bacterial origin, are the primary catalyst for soil iodination in aerobic, surface soils of deciduous and coniferous forests, and that soil N content may be indicative of the availability of binding sites for reactive iodine species.
Complexity and controversy in media coverage of Human papillomavirus (HPV) vaccination: A qualitative content analysis of news coverage in Denmark 2008–2018
Authors: Agergaard Torben E. , Smith Màiri E. , Gammelby Ane Kathrine , Tørring Marie Louise , Nielsen Kristian H. 
Published: March 2023

IntroductionTraditional news media play an important, yet notoriously complex role in vaccination communication. News media remain a common source of information about vaccines and potentially influence individual decisions to choose vaccination or not. In Denmark, Human papillomavirus (HPV) vaccination rates remained relatively high until suspected adverse reactions began to receive extensive coverage in the news. Existing research studies associate the decline in HPV vaccination rates with misleading or negative news stories.MethodsWe probed Danish media coverage beyond dichotomies such as misleading vs. informative, or negative vs. positive. We combined quantitative and qualitative approaches to media coverage of the Danish HPV vaccination crisis and recovery. Our research design focused on six national newspapers and allowed us to identify 865 articles published in periods of peak media coverage from 2008 to 2018 (extracted from a total sample of 1,437 articles published between 1991 and 2019). We used qualitative content analysis to discern the main topics covered, and we analyzed contextual factors that affected the meanings of our main topics.ResultsOur results confirm the rise of suspected adverse reactions as the dominant main topic in 2015. However, we find that news stories about adverse reactions were diverse and closely related to other main topics such as conflicts of interests and debate among experts and other stakeholders. In 2017, the media began downplaying suspected adverse reactions when concerns about declining vaccination rates and misinformation by the media were voiced.DiscussionOur findings suggest that controversial media messages about vaccination are hard to classify as either negative or positive but must be interpreted carefully in context of what is known about the controversy. Learning from past media controversies remains important to understanding the media's role in the social construction of risks and benefits associated with vaccination.
Macrophage polarization markers in subcutaneous, pericardial, and epicardial adipose tissue are altered in patients with coronary heart disease
Authors: Papotti Bianca , Opstad Trine Baur , Åkra Sissel , Tønnessen Theis , Braathen Bjørn , Hansen Charlotte Holst , Arnesen Harald , Solheim Svein , Seljeflot Ingebjørg , Ronda Nicoletta 
Published: March 2023

BackgroundEpicardial and pericardial adipose tissue (EAT and PAT) surround and protect the heart, with EAT directly sharing the microcirculation with the myocardium, possibly presenting a distinct macrophage phenotype that might affect the inflammatory environment in coronary heart disease (CHD). This study aims to investigate the expression of genes in different AT compartments driving the polarization of AT macrophages toward an anti-inflammatory (L-Galectin 9; CD206) or pro-inflammatory (NOS2) phenotype.MethodsEAT, PAT, and subcutaneous (SAT) biopsies were collected from 52 CHD patients undergoing coronary artery bypass grafting, and from 22 CTRLs undergoing aortic valve replacement. L-Galectin9 (L-Gal9), CD206, and NOS2 AT gene expression and circulating levels were analyzed through RT-PCR and ELISA, respectively.ResultsL-Gal9, CD206, and NOS2 gene expression was similar in all AT compartments in CHD and CTRLs, as were also L-Gal9 and CD206 circulating levels, while NOS2 serum levels were higher in CHD (p = 0.012 vs. CTRLs). In CTRLs, NOS2 expression was lower in EAT vs. SAT (p = 0.007), while in CHD patients CD206 expression was lower in both SAT and EAT as compared to PAT (p = 0.003, p = 0.006, respectively), suggestive of a possible macrophage reprogramming toward a pro-inflammatory phenotype in EAT. In CHD patients, NOS2 expression in SAT correlated to that in PAT and EAT (p = 0.007, both), CD206 expression correlated positively to L-Gal9 (p &lt; 0.001) only in EAT, and CD206 expression associated with that of macrophage identifying markers in all AT compartments (p &lt; 0.001, all). In CHD patients, subjects with LDL-C above 1.8 mmol/L showed significantly higher NOS2 expression in PAT and EAT as compared to subjects with LDL-C levels below (p &lt; 0.05), possibly reflecting increased cardiac AT pro-inflammatory activation. In SAT and PAT, CD206 expression associated with BMI in both CHD and CTRLs (p &lt; 0.05, all), and with L-Gal9 in EAT, however only in CTRLs (p = 0.002).ConclusionCHD seems to be accompanied by an altered cardiac, and especially epicardial AT macrophage polarization. This may represent an important pathophysiological mechanism and a promising field of therapy targeting the excessive AT inflammation, in need of further investigation.
Left ventricular systolic function in subjects conceived through assisted reproductive technologies
Authors: Sciuk Franziska , Vilsmaier Theresa , Kramer Marie , Langer Magdalena , Kolbinger Brenda , Li Pengzhu , Jakob André , Rogenhofer Nina , Dalla-Pozza Robert , Thaler Christian , Haas Nikolaus Alexander , Oberhoffer Felix Sebastian 
Published: March 2023

BackgroundOver the past decades, assisted reproductive technologies (ART) have gained remarkable influence in the treatment of infertility and account for more than 2 % of births in European countries nowadays. Accumulating evidence suggests ART to cause cardiovascular alterations, including left ventricular (LV) dysfunctions, within its offspring. The aim of this study was to assess LV systolic function in subjects conceived through ART in comparison to spontaneously conceived peers.MethodsFor the assessment of LV morphology and LV function, M-Mode echocardiography, pulsed wave Doppler and two-dimensional speckle tracking echocardiography (2DSTE) were applied. LV ejection fraction (EF) and fractional shortening (FS) were assessed in M-Mode and calculated by Teichholz formula. EF was additionally assessed semiautomatically through 2DSTE.ResultsIn total, 64 ART subjects and 83 spontaneously conceived controls with no significant differences in age (12.52 ± 5.64 years vs. 13.20 ± 5.95 years, p = 0.486) and sex were included in the analysis. In the ART cohort, significantly lower values were observed for M-Mode assessed EF (63.63 ± 5.17 % vs. 65.35 ± 5.10 %, p = 0.046) and FS (34.26 ± 3.87 % vs. 35.60 ± 3.84 %, p = 0.038). However, after the adjustment for birth weight percentile and gestational age, M-Mode assessed EF and FS displayed no significant differences between both groups. LV morphology and remaining systolic function parameters, such as mitral annular plane systolic excursion, aortic velocity time integral, global peak longitudinal strain and 2DSTE measured EF, were comparable between both groups.ConclusionThis study suggests a lower LV systolic function in ART subjects, visualized by significantly lower values for M-Mode assessed EF and FS, compared to spontaneously conceived peers. The clinical relevance of these findings has to be investigated as the above-mentioned parameters were in normal reference range. In addition, LV systolic function parameters evaluated by other echocardiographic imaging modalities were comparable between both groups. Therefore, further studies will be required to evaluate the influence of ART on LV systolic function and cardiovascular morbidity in the future.
The relationship between the pan-immune-inflammation value and long-term prognoses in patients with hypertension: National Health and Nutrition Examination Study, 1999–2018
Authors: Wu Bo , Zhang Chenlu , Lin Shuqiong , Zhang Yanbin , Ding Shan , Song Wei 
Published: March 2023

BackgroundDirect antihypertensive therapy in hypertensive patients with a high CVD risk can reduce the incidence of cardiovascular death but increase adverse cardiovascular events, so additional ways to identify hypertensive patients at high risk may be needed. Studies have shown that immunity and inflammation affect the prognoses of patients with hypertension and that the pan-immune-inflammation value (PIV) is an index to assess immunity and inflammation, but few studies have applied the PIV index to patients with hypertension.ObjectiveTo explore the relationship between the PIV and long-term all-cause and cardiovascular mortality in patients with hypertension.MethodData from the National Health and Nutrition Examination Survey (NHANES) 1999–2018 with a mortality follow-up through December 31, 2019, were analyzed. A total of 26,781 participants were evaluated. The patients were grouped based on PIV levels as follows: T1 group (n = 8,938), T2 group (n = 8,893), and T3 group (n = 8,950). The relationship between the PIV and long-term all-cause and cardiovascular death was assessed by survival curves and Cox regression analysis based on the NHANES recommended weights.ResultThe PIV was significantly associated with long-term all-cause and cardiovascular mortality in patients with hypertension. After full adjustment, patients with higher PIV have a higher risk of all-cause [Group 3: HR: 1.37, 95% CI: 1.20–1.55, p &lt; 0.001] and cardiovascular [Group 3: HR: 1.62, 95% CI: 1.22–2.15, p &lt; 0.001] mortality.ConclusionElevated PIV was associated with increased all-cause mortality and cardiovascular mortality in hypertensive patients.