bluuebunny/crossref_metadata_2025_split huggingface dataset:
PRODUKSI, KOMPOSISI BOTANI DAN KAPASITAS TAMPUNG PADANG PENGGEMBALAAN ALAM DESA MAUBOKUL KECAMATAN PANDAWAI KABUPATEN SUMBA TIMUR PADA MUSIM HUJAN (Production, botanical composition and carrying capacity of pasture in Maubokul Village, Pandawai.....
Authors: Hambakodu Marselinus 
Published: September 2023

This experiment aims to analyze the production, botanical composition, and carrying capacity of pasture in the Maubokul Village, Pandawai District, East Sumba Regency. The experiment was conducted on March 1th to April 30th 2022. The experiment used survey method, measurement, and direct observations in the field. Forage production measured by actual weight estimate method with 1 m x 1 m of the frame as tool utilization. Botanical composition measured using the summed dominance ratio method, as well as the carrying capacity measured using the viosin formula. The data obtained were tabulated and calculated to obtain the total forage production, botanical composition, and carrying capacity. The results showed that the pasture in Maubokul Village, Pandawai District, had a fresh production of 5.182 kg/ha, dry matter production of 1.505 kg/ha, Summed Dominance Ratio (SDR) of grass 65,21%, legumes 18,04%, and weeds 16,75%. The pasture also has a carrying capacity of 1,12 AU/ha/year. In conclusion, pasture in Maubokul Village, Pandawai District were dominated by natural grass with high capacity during the rainy season.
Nulla salus extra bollam: il principio del pluralismo informativo nell’epoca delle echo chambers
Authors: Paolanti Matteo 
Published: September 2023

Nella nuova società digitale si ha l’impressione che il principio del pluralismo informativo venga sempre meno rispetto alle caratteristiche tracciate dalla dottrina e dalla giurisprudenza negli ultimi decenni. Le c.d. Echo Chambers o “Bolle filtro” non fanno che ridurre progressivamente l’orizzonte dell’informazione che dovrebbe far capo ad ogni individuo, facendo sì che quest’ultimo sia sempre maggiormente condotto verso pochi canali di approvvigionamento di notizie, i quali non fanno che impoverire la conoscenza rispetto alla realtà circostante e, di conseguenza, il dibattito pubblico che ne dovrebbe nascere. In questo elaborato si proverà ad analizzare come sia sorto il concetto di pluralismo informativo, come esso si sia evoluto con il passare del tempo e se esso sia ancora adatto a regolare la realtà che viviamo.
In our digital society the principle of pluralism is fading compared to the characteristics outlined by doctrine and jurisprudence in the last decades. The so-called Echo Chambers or "Filter bubbles" progressively reduce the information horizon that should belong to each individual, which do impoverish knowledge of the surrounding reality and, consequently, the public debate that should arise from it. In this essay we will try to analyze how the concept of pluralism was created, how it has evolved over time and whether it is still suitable for regulating the reality we live in.
Clinical significance of adanced glycation end products and inflammation products in the development of vascular calcification and cardiovascular complications in chronic kidney disease
Authors: Dzgoeva F. U. , Remizov O. V. , Ikoeva Z. R. , Goloeva V. G. , Gusalov A. A. 
Published: September 2023

Background. Vascular calcification underlies cardiovascular complications, which remain the leading cause of high mortality in chronic kidney disease (CKD). Uremic toxins, including the advanced glycation end products, play a significant role in the formation of this process.The Aim of the study is to clarify the role of the advanced glycation end products (AGEs) and inflammationproducts in the processes of vascular calcification at different stages of CKD.Patients and Methods. 105 patients aged 18 to 66 years at different stages of CKD C1-C5D were examined, 75 of which were caused by diabetic nephropathy (DN), 30 by other nosological forms. Serum concentrations of AGEs, IL6, TNF-α, troponin I, parathyroid hormone (PTH) were determined by enzyme immunoassay (ELISA). To study the AGEs concentration, the serum was separated by centrifugation (in Eppendorf tubes). The samples were stored at – 70 °C. The left ventricular myocardial mass index (LVMI) was determined. Left ventricular hypertrophy (LVH) was diagnosed with LVH>115 g/m2 for men and >95 g/m2 for women. The peak systolic velocity of blood flow in the aortic arch (Vps) was studied by duplex scanning using the Doppler effect.Results. A significant increase in serum phosphorus concentration (p < 0.05) and PTH (p< 0.01) was revealed as the glomerular filtration rate decreased. An increase in the concentration of AGEs, IL6 and TNF-α was found at all stages of CKD, most pronounced at the later stages – C4-C5D ((p< 0.01, p< 0.05, p<0.05, respectively). Pronounced changes in LVMI and Vps were associated with high levels of AGEs, IL6 and TNF-α. CONCLUSION. An increase in the level of glycation end products and inflammatory factors directly and reliably correlated with the severity of uremia and the severity of morphofunctional changes in the heart and aorta, which confirms their significant role in the development of cardiovascular complications in CKD. Keywords: advanced glycation end products, inflammation, vascular calcification, chronic kidney disease>˂0.05, respectively). Pronounced changes in LVMI and Vps were associated with high levels of AGEs, IL6 and TNF-α.Conclusion. An increase in the level of glycation end products and inflammatory factors directly and reliably correlated with the severity of uremia and the severity of morphofunctional changes in the heart and aorta, which confirms their significant role in the development of cardiovascular complications in CKD.
Тромбоцитопения и COVID-19 – предизвикателството все още остава
Authors: Славчева Попова Ваня 
Published: September 2023

Бързото разпространение на COVID-19, както и критичният брой на смъртните случаи в световен мащаб наложиха необходимостта за кратко време да се предприемат ефективни мерки за ограничаване разпространението на заболяването, изграждане на диагностично терапевтичен алгоритъм и мерки, свързани с превенция на болестта. Към днешни дни е общоприето становището за системния характер на заболяването, като в немалка част от наличните доклади са представени данни за ангажиране на хемопоезата.
Целта на настоящия преглед е на базата на публикувани доклади за периода след 2019 г. да се направи обзор върху възможните патогенетични механизми, водещи до развитие на тромбоцитопения при пациенти с доказан COVID-19.
Случай на водене на бременност и раждане при тежък дефицит на фактор XII
Authors: Деянова-Илиевска Виолета , Макаровска-Бояджиева Татяна , Велкова Емилия , Петковик Елена , Ристовска Елена , Тодоровски Боян , Кочоски Горан 
Published: September 2023

Дефицитът на фактор XII е рядко нарушение на кръвосъсирването, което теоретично носи риск от кървене в резултат на намалени коагулационни фактори или риск от тромбоза в резултат на намалена фибринолитична активност. Честотата на дефицит на фактор XII е относително ниска – 1 на 1 000 000 души.
Целта на докладвания случай е да подчертае значението на мултидисциплинарния подход при воденето на бременността и раждането при жени с тежък дефицит на фактор XII.
Жена с тежък дефицит на фактор XII беше успешно лекувана по време на двете си бременности и раждания. Всички тестове за коагулация бяха извършени със стандартни реактиви на Siemens на коагулометър Dade Behring BCS XP. Тест за тромбоцитна агрегация за проследяване на лечението с аспирин беше извършен на Siemens Innovation PFA-200 със стандартен тестов патрон за колаген/епинефрин на Siemens.
По време на двете си бременности жената с тежък дефицит на фактор XII е проследявана редовно в Центъра по хемофилия към Института по трансфузионна медицина. Според коагулационните изследвания при първата бременност е лекувана с нискомолекулен хепарин в следродилния период, но при втората бременност се е наложило лечение в първи и трети триместър, както и в следродовия период. Предотвратяването на кървене поради раждане се извършва с транексамова киселина. Две бременности бяха успешно завършени с естествено раждане без кървене или тромботични усложнения.
Редовното проследяване по време на бременност е необходимо за жени с нарушения на кръвосъсирването в Центъра за комплексно лечение на хемофилия. Мултидисциплинарният подход е от решаващо значение за успешното лечение на нарушения на кръвосъсирването.
Мултифакторна генеза на тромбообразуването при синдром на Бъд-Киари – клиничен случай
Authors: Киндеков Иван , Милчева Камелия 
Published: September 2023

Цел: Миелопролиферативните неоплазии (МПН) са хетерогенна група клонални заболявания на хемопоетичните стволови клетки, характеризиращи се с повишена пролиферация на клетки от миелоидния ред в костния мозък (КM). Ph-негативните MПН са най-честият рисков фактор за тромбоза на вена лиеналис (ТВЛ), включваща синдром на Бъд-Киари (БКС) и тромбоза на порталната вена (ТПВ). Редица проучвания разглеждат ролята на различните етиологични и рискови фактори за ТВЛ, включващи придобити протромботични състояния, наследствена тромбофилия и локални заболявания. Настоящото съобщение описва рядко срещан клиничен случай на пациентка с 3 рискови фактора за БКС: Ph-нег. МПН, причинена от придобита мутация JAK2V617F, наследствено нарушение на кръвосъсирването, фактор V Leiden мутация, и употреба на хормонална контрацепция.
Материал и методи: Диагностично-терапевтичният алгоритъм при конкретната пациентка прецизно следва актуалните препоръки за поведение при това състояние, включващо и оценка на всички възможни протромботични рискови фактори.
Резултати: Пациентката продължава своето регулярно проследяване от гастроентеролог и хематолог, поддържайки добро качество на живот без нови тромботични инциденти и нормални хематологични показатели.
Заключение: Представеният клиничен случай потвърждава ролята на рутинния скрининг за МПН при ТВЛ. Откроява необходимост от извършване на скрининг за вродена тромбофилия, независимо от JAK2 статуса на пациента, поради вероятността за мултифакторна генеза на тромбообразуване при тези състояния, които от своя страна налагат прилагането на различни по механизъм на действие антитромботични терапии.
Formulation and evaluation of a herbal shampoo using flavonoid glycosides from Dicerocaryum senecioides
Authors: Pamhidzai Dzomba  
Published: September 2023

Trichophyton tonsurans affecting the scalp skin and hair shaft, is the most common public health problem in children in most countries. Multidrug T. tonsurans resistance has been observed leading to clinical treatment failure and relapse. In the present study, a herbal shampoo was formulated using flavonoid glycosides from Dicerocaryum senecioides as active principal components. Flavonoids glycosides were isolated using a bioassay directed protocol, Thin Layer Chromatography (TLC) p-iodonitrotetrazolium violet bio-autography. The formulated herbal shampoo efficacy was tested using the poisoned food assay with clinical strains isolated from patients showing resistance to conventional medicines that are marketed locally. Ten volunteers, 6 girls and 4 boys also participated in assessing the efficacy of the herbal shampoo. From the 10 participants, 3 were blindly given shampoos that did not consist of the flavonoids glycosides. Quality characteristics of the shampoo were determined by monitoring pH changes, microorganisms, colour and viscosity changes, and presence of rancid ordors. The herbal shampoo showed significant mycelial growth inhibitory activity of 93.2 ± 0.6% on the poisoned food assay. All the 7 participants administered with the experimental shampoo were healed by washing their scalp once per day and the condition did not appear again while for the 3 administered with the placebo the condition remained. The condition disappeared when they were administered the experimental shampoo later on. Sensory quality analysis shows that pH of 6.85, green leaf colour and smell were maintained throughout the period of study. The viscosity was also consistent. No microorganism or molds were found in the shampoo. The results obtained from this study showed that the herbal shampoo is an effective alternative option against T. tonsurans scalp skin and hair shafts infections. The flavonoid glycosides maybe utilized to make herbal shampoo for scalp infections.
SEMANTIC-SYNTACTIC EXPLICATION OF THE VALENCE POTENTIAL OF THE VERB- TERMS АКОМПАНУВАТИ AND ДИРИГУВАТИ
Authors: Stashkiv Solomiia 
Published: September 2023

The article examines the valence potential of verb-terms акомпанувати and диригувати. The three-component nature of their valence framework was substantiated, and the main lexical-semantic groups of words that explain all non-predicate arguments were
defined. Typical morphological variants of addressee, object, and instrumental arguments were also established.
It was found that the verb акомпанувати generates three non-predicate valenceconditioned components: the subject of the action (the person who performs the accompaniment), the addressee of the action (a musician or group of musicians who are accompanied), the instrument of action (actually a musical instrument on which a melody is performed for accompaniment). The subject component dependent on the verb акомпанувати is expressed by the names of persons (proper and common) either quantified or unquantified
sets of persons who accompany. The instrumental component, which is determined by the verb акомпанувати, is most consistently realized by the names of musical instruments. It was emphasized that the verb акомпанувати is intransitive, therefore it can’t determine
the object component, despite its synonymy with the transitive verb супроводжувати (orchestra, choir, etc.).
The trivalency of the verb-term диригувати has been established. The non-predicate components of the subject of the action (the person who conducts), of the object of the action (a piece of music that is conducted), and of the instrument of the action (an instrument
used to conduct) in its valence environment. Among all the components that cause the verb диригувати, the object of action has the broadest lexical-semantic content, represented by proper and general names of musical groups, works, and their fragments.
A conclusion was made about the semi-obligatory usage of the instrument of the action with the verb акомпанувати and the optional usage with the verb диригувати, the difference in its lexical-semantic expression was noted. The instrumental component, which is determined by the verb акомпанувати, is most consistently implemented by the names of musical instruments; in the verb диригувати it is lexically limited by the nouns hand and stick.
Constraining Cosmological Parameters Using the Cluster Mass–Richness Relation
Authors: Abdullah Mohamed H. , Wilson Gillian , Klypin Anatoly , Ishiyama Tomoaki 
Published: September 2023

Abstract
The cluster mass–richness relation (MRR) is an observationally efficient and potentially powerful cosmological tool for constraining the matter density Ωm and the amplitude of fluctuations σ
8 using the cluster abundance technique. We derive the MRR relation using GalWCat19, a publicly available galaxy cluster catalog we created from the Sloan Digital Sky Survey-DR13 spectroscopic data set. In the MRR, cluster mass scales with richness as

log

M

200

=
α
+
β
log

N

200

. We find that the MRR we derive is consistent with both the IllustrisTNG and mini-Uchuu cosmological numerical simulations, with a slope of β ≈ 1. We use the MRR we derived to estimate cluster masses from the GalWCat19 catalog, which we then use to set constraints on Ωm and σ
8. Utilizing the all-member MRR, we obtain constraints of Ωm =

0.31

−
0.03

+
0.04

and σ
8 =

0.82

−
0.04

+
0.05

, and utilizing the red member MRR only, we obtain Ωm =

0.31

−
0.03

+
0.04

and σ
8 =

0.81

−
0.04

+
0.05

. Our constraints on Ωm and σ
8 are consistent and very competitive with the Planck 2018 results.
Staphylococcus aureus Enterotoxin B Is a Cofactor of Food Allergy beyond a Superantigen
Authors: Yuan Jin , Tong Ping , Wang Zhongliang , Xu Xiaoqian , Zhao Xiaoli , Meng Xuanyi , Wu Yong , Li Xin , Gao Jinyan , Chen Hongbing 
Published: September 2023

Abstract
Staphylococcus aureus enterotoxin B (SEB), one of the most common bacterial toxins in food contamination, has been poorly understood in relationship to food allergy outcomes. To investigate whether the ingestion of enterotoxins in food allergens could affect the development of food allergy, OVA-sensitized female BALB/c mice were challenged with OVA added with different doses of SEB or LPS. Allergic symptoms, such as diarrhea rate and hypothermia, could be aggravated in mice challenged with OVA and a low dose of SEB. The increased differentiation of Th2 and reduced expression of CD103 in dendritic cells was found in mice coexposed to SEB and OVA. Additionally, there was an increasing differentiation of Th1 induced by a high dose of SEB. The expression of ST2+ in intestinal mast cells was also increased in mice sensitized with a low dose of SEB and OVA. Employing several in vitro cell culture models showed that the secretion of IL-33 from intestinal epithelial cells and IL-4 from group 2 innate lymphoid cells, activation of bone marrow–derived dendritic cells, and differentiation of naive T cells were induced by SEB and OVA. Our work proved that challenge with low-dose SEB and OVA partly aggravated the food allergy, suggesting a (to our knowledge) new finding of the potential cofactor of food allergy and that the contamination of SEB in food allergens deserves attention for allergic and normal individuals.
Healthcare-associated Staphylococcus aureus infections in children in Turkey: A six-year retrospective, single-center study
Authors: Yakut Nurhayat , Ergenc Zeynep , Tuncay Sevgi Aslan , Bayraktar Sezin , Sayin Elvan , Ilki Arzu , Kepenekli Eda 
Published: September 2023

Objective:
To describe clinical and epidemiological characteristics, antimicrobial susceptibility and mortality-associated factors of healthcare-associated infections (HCAIs) caused by Staphylococcus
(S.) aureus in children.

Methods:
We conducted a retrospective, single-centre study of pediatric HCAIs caused by S. aureus from a tertiary care hospital in Turkey between February 2014 and December 2019. The clinical and epidemiological characteristics and antimicrobial susceptibility of the methicillin-susceptible and methicillin-resistant S. aureus (MSSA and MRSA) isolates was evaluated.

Results:
A total of 310 pediatric patients were examined. Overall, 225 (72.6%) isolates were MSSA and 85 (27.4%) were MRSA. All S. aureus isolates were susceptible to teicoplanin, vancomycin, linezolid, tigecycline, mupirocin, and daptomycin. Penicillin resistance rates were high (89.0%), while fosfomycin, gentamicin, and clindamycin resistance rates were low (1.3%, 1.0%, and 2.3%, respectively). Except susceptibility to fosfomycin, which was significantly lower in 2014 compared to 2018 and 2019, no significant difference was found in the antimicrobial susceptibility of S. aureus isolates between the years. Baseline characteristics and mortality rate were similar comparing MRSA and MSSA causing HCAIs. The mortality rate of HCAIs caused by S. aureus was 6.5% (20 patients). Malignancy was an independent risk factor associated with mortality in the multivariate analysis (OR 5.446, 95% CI 1.573-18.849).

Conclusions:
Our findings demonstrate that MSSA remained the most causative agent of HCAIs caused by S. aureus. The mortality rate was 6.5%, the antibiotic resistance rate was quite high for penicillin and diagnosis of malignancy was the main risk factor for increasing mortality in children. These findings could help improve the management of HCAIs caused by S. aureus in children.
Knowledge, Attitude and Behavioural Survey Regarding Oral Hygiene Practices amongst Rural and Urban Population of Ahmedabad City, Gujarat: A Comparative Study
Authors: Patel Eshita Dasharathbhai , Parikh Hiral Akshat , Joshi Keyur H , Soni Prerna , Unjia Alay , Soni Maahi , Mehta Isha 
Published: September 2023

Introduction:
It is thought that oral hygiene can be influenced by socioeconomic status to some extent. People with higher socioeconomic status often have better access to resources and opportunities, which can impact their oral hygiene practices and overall dental health. Hence, this study assessed knowledge, attitude and behaviour regarding oral health amongst the adult population in urban and rural populations of Ahmedabad city.

Materials and Methods:
This cross-sectional study was carried out amongst the urban and rural segments of Ahmedabad district. The zones of the district and participants were selected by systematic random sampling method. The participants in the Ahmedabad district were selected, and those 204 who fulfilled the inclusion criteria were considered. A validated questionnaire was designed in our study so as to satisfy the quality, attain the objective of our study and make the study effective.

Results:
About 70.42% of the rural population and 77.30% of the urban population has good knowledge, while only 36.1% of the rural population and 47.16% of the urban population had a positive attitude towards oral hygiene practices. 61.27% of the rural population and 64.81% of the urban population showed positive behaviour. The absence of correlation was identified between knowledge-attitude and attitude-behaviour.

Conclusion:
It has been found that a massive number of the urban population possess a higher level of knowledge and attitude towards oral health than the rural population. No linear positive correlation was seen in knowledge, attitude and behaviour towards oral health.