bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lean monitoring: action research in manufacturing
Authors: Kassem Bassel , Rossini Matteo , Costa Federica , Portioli-Staudacher Alberto 
Published: August 2023

Purpose
This study aims to study the implementation of lean thinking at the strategic level of an Italian manufacturing company. Companies implementing continuous improvement (CI) projects in their production processes often take the monitoring phase for granted. This research deploys an A3 lean thinking project in the monitoring phase of strategic KPIs upon completion of several ongoing improvement projects.

Design/methodology/approach
The research methodology is action research aiming at disseminating the problems that the company is facing. The study relies on the lean action plan developed by Womack and Jones (2003): Planning for lean and Lean action. Lean planning consists of the following steps: find a change agent; get the knowledge; find a lever. Lean action uses the A3 lean approach.

Findings
The company reached high-performance improvements due to the proposed lean action plan.

Research limitations/implications
This study contributes by presenting a lean action plan in the monitoring phase, highlighting the importance of the lean thinking-monitoring continuum in reducing time waste for faster diagnosis and using action research to analyze and instill reflective learning.

Originality/value
The research relies on the A3 methodology to showcase the benefits that a mature paradigm, often coined to production, still has unexplored potentials.
TNF‐like weak inducer of apoptosis inhibition is comparable to IL‐13 blockade in ameliorating atopic dermatitis inflammation
Authors: Gupta Rinkesh K. , Miller Jacqueline , Croft Michael 
Published: August 2023

AbstractBackgroundTargeting IL‐13 is highly efficacious in patients with Th2‐biased atopic dermatitis (AD), but inhibition of other inflammatory molecules might also limit disease. We investigated the importance of the TNF family cytokine TNF‐like weak inducer of apoptosis (TWEAK; TNFSF12) to keratinocyte dysregulation and the pathogenesis of AD in mice and also tested if blocking TWEAK has a similar therapeutic effect as targeting IL‐13.MethodsConditional knockout mice lacking Fn14 (TNFRSF12A), the receptor for TWEAK, only in keratinocytes, were repetitively sensitized with house dust mite allergen and analyzed for AD‐like skin inflammation. To determine the translational potential, wild‐type mice with AD were therapeutically treated with anti‐TWEAK and/or anti‐IL‐13 antibodies, and skin inflammation was assessed.ResultsMice deficient in Fn14 in keratinocytes were resistant to developing maximal clinical features of AD, exhibiting reduced epidermal hyperplasia and dermal thickening, less skin infiltration of immune cells, and downregulated inflammatory gene expression. Moreover, therapeutic neutralization of TWEAK in wild‐type mice with AD reduced all of the pathological features to a comparable extent as blocking IL‐13.ConclusionsThe activity of TWEAK in keratinocytes contributes to AD development, and neutralizing TWEAK represents a future potential therapeutic option in human AD similar to targeting IL‐13.
Optimizing efficiency and resilience of no‐take marine protected areas for fish conservation under climate change along the coastlines of China Seas
Authors: Lin Li , Liu Yang , Yan Yang , Kang Bin 
Published: August 2023

AbstractClimate change is one of the major threats to coastal fish biodiversity, and optimization of no‐take marine protected areas (MPAs) is imminent. We predicted fish redistribution under climate change in coastal China Seas with joint species distribution modeling and prioritized areas for conservation with Zonation, for which we used core area zonation (CAZ) and additive benefit function (ABF). Based on our results, we devised an expansion plan of no‐take MPAs. Under climate change, fish were redistributed northward along the coast. These redistributions were segmented by the Yangtze River estuary and its adjacent waters, indicating a possible biogeographical barrier. Under CAZ and ABF, significantly more fish habitat was conserved than under random prioritization (p < 0.001, Cohen's d = –0.36 and –0.62, respectively). The ABF better represented areas with higher species richness, whereas CAZ better represented core habitats for species with narrow distributions. Without accounting for species redistribution, the expanded MPAs were mainly distributed in the northwest of the South China Sea, the East China Sea, the north of the Yellow Sea, and the west of the Bohai Sea. When accounting for species redistribution, the proposed MPAs were mainly distributed in the north of the Bohai Sea and southwest of the Yellow Sea, corresponding to the northern species redistributions. These MPAs conserved less habitat for fishes at present but protected more and better quality habitat for fishes in 2050 and 2100 than those MPAs that did not account for species redistribution, indicating improved fish conservation under climate change. Incorporating species redistribution and trade‐offs between areas with high species richness and areas that contain habitats for rare species are suggested to address coastal fish conservation under climate change. This work provides valuable information for fish conservation and is a precursor to systematic conservation planning along the coastlines of China Seas.
Islet graft function by mixed meal tolerance testing is sustained over 4 years in young children undergoing total pancreatectomy with islet autotransplantation
Authors: Gnikpingo Taylor , Benson Sydney , Hodges James S. , Downs Elissa , Cook Marie , Schwarzenberg Sarah J. , Chinnakotla Srinath , Bellin Melena D. 
Published: August 2023

AbstractChildren with intractable chronic pancreatitis may require total pancreatectomy with islet autotransplantation (TPIAT) for pain relief. The IAT reduces the severity of post‐ pancreatectomy diabetes. We analyzed 635 mixed meal tolerance tests (MMTT) in 134 children undergoing TPIAT to determine whether superior survival of islet grafts explains higher rates of insulin independence previously reported in young children (n = 52, age 3–11 years) versus adolescents (n = 82, age 12–18 years). For MMTT, children consumed Boost HP and we sampled C‐peptide and glucose repeatedly over 2 h. The trajectory of outcomes before and after TPIAT was compared between children and adolescents using data from pre‐TPIAT and 3, 6 months, 1, 2, 3, and 4 years post‐TPIAT and mixed linear models with a random effect for child. Cox regression was used to analyze time outcomes (e.g., time to first off insulin). Islet mass transplanted, measured as islet equivalents (IEQ), was higher in adolescents (p = .003) but IEQ/kg was higher in young children (p < .001) because of their lower weight. AUC C‐peptide in young children increased somewhat over 4 years, but was stable in adolescents (p = .0013). AUC glucose increased more in adolescents over time post‐TPIAT (p = .0024). Islet function by AUC C‐peptide:AUC glucose ratio was better preserved in young children (p < .001). Adolescents were less likely to wean off insulin (hazard ratio .44 [95% CI .28, .69]). These data support an advantage of young age in islet graft survival after TPIAT. The greater likelihood of insulin independence in young children may be driven by better islet survival after transplant.
Hepatitis C and heart transplantation: An update
Authors: Nunez Marina , Kelkar Anita A. 
Published: August 2023

AbstractThere are limited data regarding heart transplantation in the setting of hepatitis C virus (HCV) infection in either recipients or donors, as the practice was infrequent, given concerns of worse post‐transplant outcomes. This changed dramatically after the development of highly effective HCV therapies, namely direct‐acting antivirals (DAAs). Additionally, nucleic acid testing currently in use establishes more precisely the risk of HCV transmission from donors. As a result, chronic HCV infection in itself is no longer a barrier for heart transplant candidates, and the use of HCV‐positive organs for HCV‐infected and non‐infected transplant candidates has increased dramatically. A review of the literature revealed that in the pre‐DAA era, HCV seropositive heart transplant patients had a higher mortality than their seronegative counterparts. However, short‐term data suggest that the differences in survival have been erased in the DAA era. Heart transplantation from HCV‐viremic donors to HCV‐uninfected recipients has become increasingly common as the number of deceased donors with HCV viremia has increased over the past years. Preliminary outcome reports are very encouraging, although further data are needed with regard to long‐term safety. New information continues to be incorporated to optimize protocols that guide this practice.
Cerebral palsy pain instruments: Recommended tools for clinical research studies by the National Institute of Neurological Disorders and Stroke Cerebral Palsy Common Data Elements project
Authors: Schiariti Verónica , Shierk Angela , Stashinko Elaine E. , Sukal‐Moulton Theresa , Feldman Robin S. , Aman Clara , Mendoza‐Puccini M. Carolina , Brandenburg Joline E. ,   the National Institute of Neurological Disorders and Stroke Cerebral Palsy Common Data Elements Oversight Committee
Published: August 2023

AbstractAimThis study describes the process of updating the cerebral palsy (CP) common data elements (CDEs), specifically identifying tools that capture the impact of chronic pain on children's functioning.MethodThrough a partnership between the American Academy for Cerebral Palsy and Developmental Medicine and the National Institute of Neurological Disorders and Stroke (NINDS), the CP CDEs were developed as data standards for clinical research in neuroscience. Chronic pain was underrepresented in the NINDS CP CDEs version 1.0. A multi‐step methodology was applied by an interdisciplinary professional team. Following an adapted CP chronic pain tools' rating system, and a review of psychometric properties, clinical utility, and compliance with inclusion/exclusion criteria, a set of recommended pain tools was posted online for external public comment in May 2022.ResultsFifteen chronic pain tools met inclusion criteria, representing constructs across all components of the International Classification of Functioning, Disability and Health.InterpretationThis paper describes the first condition‐specific pain CDEs for a pediatric population. The proposed set of chronic pain tools complement and enhance the applicability of the existing pediatric CP CDEs. The novel CP CDE pain tools harmonize the assessment of chronic pain, addressing not only intensity of chronic pain, but also the functional impact of experiencing it in everyday activities.
“Bronchogenic cyst impersonating a pericardial lesion”: A case report
Authors: Javier Cruz‐Zarrabal , Santibañez‐Escobar Felipe , Aranda‐Fraustro Alberto , Arias‐Godinez Jose A , Fritche‐Salazar Juan F , Ortiz‐Leon Xochitl A , G Rodriguez‐Zanella Hugo , Ruiz Esparza‐Dueñas Maria E , Posada‐Martinez Edith L 
Published: August 2023

AbstractA 32‐year‐old female presented with palpitations and chest discomfort. The patient had a history of pericardiotomy due to pericardial effusion. Multimodal imaging, including echocardiography, cardiac magnetic resonance (CMR), and coronary computed tomography angiography (CCTA) showed a single mass in the pericardium as the cause of the symptoms. Furthermore, its location and potential complications were accurately defined. The patient underwent a successful surgical resection of the pericardial cyst, microscopic histopathological examination was compatible with a bronchogenic cyst, a very rare congenital malformation. The article discusses the rarity of bronchogenic cysts in the pericardium and the importance of accurate diagnosis and appropriate treatment.
Substantial fitness costs in terms of parasitization rates, offspring production and sex ratio of Wolbachia infection in Nasonia vitripennis without modified host preference
Authors: Kalyanaraman Dhevi , Riemsloh Katharina Meyer Zu , Kürschner Liv Kristin , Gadau Jürgen , Lammers Mark 
Published: August 2023

Abstract
Wolbachia is a genus of endosymbiotic bacteria that is widespread among arthropods. It is responsible for manipulating various host phenotypes and often affects their host's fitness. We used the generalist parasitoid wasp Nasonia vitripennis and its endosymbiont Wolbachia to test whether and how Wolbachia affects the fitness of N. vitripennis by comparing the host preference and parasitization rate of cured and uncured N. vitripennis lines.
We reared four genotypes of wasps, each with Wolbachia infection or cured of infection, using two different host species, namely Calliphora vomitoria and Lucilia sericata, for 3–4 generations before measuring their host preference because rearing history has previously been shown to influence host preference in N. vitripennis. We found that all experimental groups significantly preferred C. vomitoria pupae. Neither rearing history nor Wolbachia infection altered N. vitripennis female's innate host preference.
Furthermore, we investigated whether Wolbachia infection may affect Nasonia's parasitization rate, offspring production and sex ratio using parasitization assays of two wasp genotypes with and without Wolbachia infection. Our results show that uncured wasps have fitness costs of harbouring Wolbachia in terms of reduced parasitization rate and offspring production in one of the host genotypes and reduced proportion of female offspring in the second host genotype tested, highlighting the context‐dependency of host–endosymbiont relationships.
Cutaneous involvement in Ph‐negative myeloproliferative neoplasms: from extramedullary hematopoiesis to myeloid metastasis with histiocytic differentiation. A systematic review of the literature
Authors: Bonometti Arturo 
Published: August 2023

AbstractMyeloid neoplasms may metastasize to the skin, presenting a wide range of clinical‐pathological features that often lead to a reduction in patients' survival. The presentation varies depending on the category of myeloid neoplasm and its prognostic significance. The literature has specifically focused on the features of acute myeloid leukemia (AML), myelodysplastic syndrome (MDS), and chronic myelomonocytic leukemia (CMML). In this article, we aimed to uncover the peculiarities of clonal skin proliferations in the course of Ph‐negative myeloproliferative neoplasms (MPNs). We conducted a systematic review and statistical analysis of the literature data. MPN patients mainly exhibited cutaneous extramedullary hematopoiesis, while a minority displayed cutaneous histiocytic lesions. Furthermore, these patients showed lower survival rates compared to the median survival of MPN patients, especially when calculating survival from the appearance of cutaneous lesions. Our work highlights, for the first time, the prognostic relevance and histological heterogeneity of cutaneous lesions in MPN. Moreover, it emphasizes the importance of dermatological and histological examinations when cutaneous lesions are present.
Exploring the anti‐inflammatory activity of sulforaphane
Authors: Treasure Katie , Harris James , Williamson Gary 
Published: August 2023

AbstractDysregulation of innate immune responses can result in chronic inflammatory conditions. Glucocorticoids, the current frontline therapy, are effective immunosuppressive drugs but come with a trade‐off of cumulative and serious side effects. Therefore, alternative drug options with improved safety profiles are urgently needed. Sulforaphane, a phytochemical derived from plants of the brassica family, is a potent inducer of phase II detoxification enzymesvianuclear factor‐erythroid factor 2–related factor 2 (NRF2) signaling. Moreover, a growing body of evidence suggests additional diverse anti‐inflammatory properties of sulforaphane through interactions with mediators of key signaling pathways and inflammatory cytokines. Multiple studies support a role for sulforaphane as a negative regulator of nuclear factor kappa‐light chain enhancer of activated B cells (NF‐κB) activation and subsequent cytokine release, inflammasome activation and direct regulation of the activity of macrophage migration inhibitory factor. Significantly, studies have also highlighted potential steroid‐sparing activity for sulforaphane, suggesting that it may have potential as an adjunctive therapy for some inflammatory conditions. This review discusses published research on sulforaphane, including proposed mechanisms of action, and poses questions for future studies that might help progress our understanding of the potential clinical applications of this intriguing molecule.
The effects of enhanced recovery after surgery on wound infection, complications, and postoperative hospital stay in patients undergoing colorectal surgery: A systematic review and meta‐analysis
Authors: Li Nianmei , Wei Shuju , Qi Yonghua , Wei Wenjng 
Published: August 2023

AbstractThis study aimed to systematically evaluate the effects of enhanced recovery after surgery (ERAS) on surgical site infections, postoperative complications, and length of hospital stay in patients undergoing colorectal surgery. A comprehensive search was conducted of PubMed, Web of Science, Ovid, EMBASE, The Cochrane Library, China National Knowledge Infrastructure (CNKI), and Wanfang Data from database inception to April 2023 to identify relevant studies on the application of ERAS in colorectal surgery. Studies were screened, and data were extracted based on predetermined inclusion and exclusion criteria. Meta‐analysis was performed using RevMan 5.4 software. A total of 22 studies, including 3702 patients (ERAS group: 1906; control group: 1796), were included in the final analysis. ERAS significantly reduced the incidence of surgical site infection (odds ratio [OR]: 0.49, 95% confidence interval [CI]: 0.34–0.69, p < 0.001), postoperative complications (OR: 0.33, 95% CI: 0.27–0.41, p < 0.001), and length of hospital stay (standardised mean difference: −1.22 days, 95% CI: −1.66 to −0.77 days, p < 0.001). These findings suggest that ERAS reduces the incidence of surgical site infections and postoperative complications and shortens the length of hospital stay in patients undergoing colorectal surgery. Therefore, ERAS should be promoted and applied in clinical practice.
Crystal structures, chemical bond features, and Raman vibrations of Li2Co2Mo3O12 microwave dielectric ceramics with low sintering temperature
Authors: Qing Zhenjun , Zou Huapeng , Zhou Xin , Li Haiyan , Liu An , Duan Shumin , Li Yingxiang , Peng Sen 
Published: August 2023

AbstractLi2Co2Mo3O12 (LCMO) ceramics were synthesized using the solid‐state reaction method. X‐ray diffraction analysis results indicated that the sole crystalline phase present in the ceramics was LCMO, which belongs to the orthorhombic structure of the Pnma space group. The sample, which was sintered at 850°C, demonstrated outstanding microwave dielectric properties, with an εr value of 8.95, a Q × f value of 43 200 GHz, and a τf value of –71.3 ppm/°C. It was found that while the main factor influencing εr was ionic polarizability, sintering density had a lesser effect on it. Furthermore, Q × f was primarily affected by relative density, and there was no significant relationship between packing fraction and this property. The higher the degree of distortion of the [Li/CoO6] octahedron is, the poorer the τf value of LCMO ceramics. Additionally, the microwave dielectric properties of LCMO ceramics were intrinsically linked to ionicity, lattice energy, bond energy, and thermal expansion coefficient of chemical bonds, with Mo–O bonds being the primary factor affecting these properties, as supported by analysis using chemical bonding theories. Mo–O bond vibration dominated the Raman spectra. Good chemical compatibility between silver and LCMO ceramics was demonstrated through our co‐firing experiment.
On the properties of NiO powders obtained by different wet chemical methods and calcination
Authors: Alastuey Patricio , Pais Ospina Daniel , Comedi David , Tirado Monica , Marin‐Ramirez Oscar 
Published: August 2023

AbstractNiO powders were synthesized using coprecipitation, sol‐gel, and hydrothermal synthesis methods. The powders were subjected to calcination in atmospheric air, followed by recalcination in an O2‐rich atmosphere at 800°C for 2 h each. Characterization techniques, such as scanning electron microscopy, X‐ray diffraction, energy dispersive X‐ray spectroscopy, and microRaman spectroscopy, were utilized. The coprecipitation and hydrothermal methods resulted in disaggregated submicrometric particles. The average size of particles obtained by the coprecipitation method after calcination in atmospheric air and recalcination in an O2‐rich atmosphere was 360 ± 140 nm and 400 ± 130 nm, respectively. Regarding the particles obtained by the hydrothermal method, the average size was 190 ± 50 and 220 ± 80 nm for calcined in atmospheric air and recalcined in O2‐rich atmosphere, respectively. Conversely, the sol‐gel method produced particle aggregates with an average size of 430 ± 150 nm after calcination in atmospheric air and 500 ± 200 nm for calcination in an O2‐rich atmosphere. X‐ray diffraction analysis revealed that only the hydrothermal method yielded pure NiO without additional Ni‐related phases, irrespective of the calcination procedure. In contrast, the coprecipitation sample exhibited a Ni2O3 phase after calcination in atmospheric air, which disappeared after recalcination in an O2‐rich atmosphere. The sol‐gel‐derived sample maintained a Ni phase after both calcination processes. Analysis of the crystallite size demonstrated an increase after recalcination in an O2‐rich atmosphere for the hydrothermal and sol‐gel‐derived samples, while a decrease was observed for the coprecipitation‐derived sample. Raman spectra exhibited defect‐enabled first‐order forbidden phonon modes that were sensitive to the synthesis route. The two magnon phonon modes also demonstrated dependency on the route, indicating variations in defect structures. Photocatalytic evaluation using methylene blue degradation in aqueous solutions indicated better performance for the powders recalcined in an O2‐rich atmosphere.
Climate variability hypothesis is partially supported in thermal limits of juvenile Northwest Atlantic coastal fishes
Authors: Strader Ryan N. , Dowd Sally C. , Blawas Camryn , Mahoney Richard D. , Patetta Natalie C. , Leslie Jaelyn , Nye Janet A. 
Published: August 2023

AbstractAs ocean warming continues to impact marine species globally, there is a need to understand the mechanisms underlying shifts in abundance and distribution. There is growing evidence that upper and lower temperature tolerances rather than mean preferences explain range shifts, but the full thermal niche is unknown for many marine species and observational data are often ill‐suited to estimate the upper and lower thermal tolerances. We quantified critical thermal maximum (CTmax) and critical thermal minimum (CTmin) using standard methods to quantify temperature limits and thermal ranges of 14 economically and ecologically important juvenile fish species on the US Atlantic coast. We then tested the climate variability hypothesis (CVH), which states that higher‐latitude species should have a wider temperature tolerance due to higher climatic variability closer to the poles. Our findings generally support the CVH in the juvenile fishes that we evaluated. However, low‐latitude species were not uniformly stenothermal. Rather, species with median occurrences across a wide range of latitudes had wide temperature tolerances, but only the tropical species we tested had more narrow ranges. These findings suggest that quantifying temperature tolerances may be used to predict which low‐latitude species are most likely to shift in response to warming water and those that may be more sensitive to climate change in this region.