bluuebunny/crossref_metadata_2025_split huggingface dataset:
Validation of the Child and Youth Resilience Measure-28 (CYRM-28) in India
Authors: Singh Kamlesh , Bandyopadhyay Shilpa , Raina Mahima 
Published: December 2022

Background: The Child and Youth Resilience Measure-28 (CYRM-28) is one of the few measures based on a contextually and culturally embedded understanding of resilience. However, its psychometric properties have not been examined in India which is home to the largest proportion of adolescents worldwide. The present study was conducted to address this gap. Aims: This study examined the psychometric properties and factor structure of the English and Hindi translated version of the CYRM-28 in the Indian context. Additionally, it investigated the role of select sociodemographic factors on the resilience levels of Indian school-going adolescents. Method: Using convenience sampling, data were collected from 1281 adolescents (mean = 15.28 years; SD = 1.08) enrolled in private and government schools in rural and urban parts of Northern India. Three measures were used in this study: CYRM-28, Warwick-Edinburg mental well-being scale (WEMWBS) and PERMA. Descriptive statistics, confirmatory factor analysis, reliability analysis, correlation, and multivariate analysis of variance were conducted to validate the scale and to study the effect of sociodemographic factors on resilience levels of India adolescents. Results: A 16-item (English and Hindi) version of the CYRM-28, with a three factor-structure was found to be the most adequate fit for the Indian context. It demonstrated good reliability and convergent validity with the WEMWBS and PERMA. Further, the multivariate results, albeit with a small effect size, showed a significant main effect for place of residence and age, with urban and older adolescents obtaining higher resilience scores than their rural and younger counterparts. Conclusion: The present research shows that a shorter 16-item version of the CYRM with a three-factor structure is a reliable and valid tool for use among Indian adolescents. The CYRM is a robust resilience measure being used across varied cultures—its validation in the Indian context widens the scope for resilience research in the Indian adolescent population.
Potential Sociodemographic Predictors of Childhood Anxiety Disorders: A Cross-Sectional Study
Authors: Mustaffa Mohamed Sharif , Bafghi Zahra Ramazanian , Ahmadi Atefeh , Haghdoost AliAkbar , Mansor Mohamed Shafeq 
Published: December 2022

Background: Previous studies have shown that the prevalence of anxiety among primary school students in rural areas is relatively high. Also, this stage is a critical developmental stage of academic life. Childhood anxiety disorders lead to significant disruption and interference with other aspects of life, including behavioral, emotional, cognitive, and academic achievement. Aims: This study aimed to find the frequency of 6 subtypes of anxiety disorders and to determine the potential sociodemographic factors of anxiety disorders among primary school students in a rural area of Malaysia. Methods: This was a cross-sectional study in which 411 students answered the Spence Children’s Anxiety Scale-Child version (SCAS-C). Descriptive analyses elucidated at-risk students, and multivariate analysis of variance and multiple linear regression presented potential predictors of anxiety disorders. Results: The most common abnormal level was for social phobia (SP) (n = 109/18.6%), and the least common were panic/agoraphobia (n = 85/14.1%) and physical injury fears (PIF) (n = 82/13.6%). Multivariate analysis of variance revealed that age ( P < .05), gender ( P < .05), father’s employment ( P < .05), and mother’s educational level (EL) P < .05) were predictors of overall anxiety. A Tukey post-hoc test revealed that older children are more likely to suffer from overall anxiety, separation anxiety (SA), SP, and obsessive-compulsive problems. Children of low-income families were less likely to suffer from SA than those of middle-income families. Children of stay-at-home mothers were less likely to suffer from overall anxiety, SA, and SP than mothers who worked more than 8 h per day. Multiple linear regression could predict 6 models of anxiety based on sociodemographic factors. Conclusion: According to our findings in this study, promoting mental health by providing preventive strategies and screening programs is more recommended for students with sociodemographic risk factors for anxiety disorders.
A hybrid sliding mode controller design for vibration suppression in a hydraulic suspension system with vertical load disturbance
Authors: Gu Jinheng , Xue Xianyang , Yang Wenjuan , Lu Gang 
Published: December 2022

Anti-disturbance vibration control is a crucial component in a hydraulic suspension system. However, random input excitation and prolonged service can cause hydraulic suspension system parameters to drift, leading to system vibration with suppression failure. The resulting states of nonlinearity and disturbance will lead to a gradual deterioration of pressure control. Therefore, designing a viable controller for a hydraulic suspension system that considers system nonlinearity, computing capacity, and sensor configuration is essential. To address this need, we present a double-layer control strategy in this work. A hybrid sliding mode control algorithm based on the reference skyhook and groundhook model is proposed to regulate the expected force of reverse compensation. An output controller is then applied based on the expected force observer to mitigate low-frequency vibrations to realize a steady state. A logic rule is designed to ensure that the two controllers work to suppress sprung mass vibration, and a comprehensive system model is derived to help characterize system nonlinearities and design the hybrid sliding model controller. Numerical and physical validations are then carried out to demonstrate the feasibility of the strategy and test the performance of the controller. The experimental results show that the hybrid sliding mode controller can suppress vibration under disturbance excitation and reduce the vibration acceleration to a 2.3 m/s2 random response when system parameters vary.
Evaluation of Racial Disparities in Suspected Child Abuse among Insured Children with Head Injury
Authors: Jones Milissa U. , Banaag Amanda , Nafea Shamim S. , Koehlmoos Tracey Perez 
Published: December 2022

Previous studies demonstrate racial disparities in child abuse evaluations even after controlling for health insurance coverage. We conducted a cross-sectional study using the Military Health System Data Repository (MDR) of Military Health System (MHS) beneficiaries born between fiscal years 2016 and 2018 to evaluate racial disparities and other factors in the suspicion of child abuse. We observed beneficiaries for 2.5 years after birth and assessed the incidence of head injury using diagnostic codes. Among children with head injury codes, we performed a multivariable logistic regression analysis to measure the association between race and the concurrent use of the diagnostic code for suspected child abuse (SCA) or for the performance of a skeletal survey. There were 195,893 infants included and 45,269 (23.1%) underwent evaluations for head injury. Less than one percent ( n = 424) concurrently had the diagnostic code for SCA or a skeletal survey performed within 2 weeks of the head injury evaluation. When controlling for other factors, race was not associated with SCA. Higher military rank was independently associated with decreased odds of SCA. Racial disparities in SCA may be mitigated in the MHS, and further evaluation is needed. Military rank could be a factor in SCA disparities and warrants further study.
National Institutes of Health pathways to prevention workshop: Improving rural health through telehealth-guided provider-to-provider communication
Authors: Wakefield Mary , Sankaranarayanan Jayashri , Conroy Joanne Mather , McLafferty Sara , Moser Robert , Murry Velma McBride , Slifkin Rebecca 
Published: December 2022

Introduction Rural communities often face chronic challenges of high rates of serious health conditions coupled with inadequate access to health care services—challenges exacerbated by the COVID-19 pandemic. One strategy with the potential to mitigate these problems is the increased use of telehealth technology. A feature of telehealth applications—collaboration between health care providers for consultation and other purposes—referred to herein as Rural Provider-to-Provider Telehealth (RPPT), introduces important expertise that may not exist locally in rural communities. Literature indicates that RPPT is operationalized through many methods with an array of purposes. While RPPT is a promising strategy that brings additional expertise to patient-centered rural care delivery, there is limited evidence addressing important considerations, including how patient access and outcomes, provider satisfaction and performance, and payment may be affected by its use. Methods Recognizing the significant potential of RPPT and the need for more information associated with its use, the National Institutes of Health convened a Pathways to Prevention (P2P) workshop to further understand RPPT's effectiveness and impact on improving health outcomes in rural settings. The P2P initiative, supported by several federal health agencies, engaged rural health stakeholders and experts to examine four key questions, identify related knowledge gaps, and provide recommendations to advance understanding of the use and impact of RPPT. Results Included in this report is a description of the process used to generate information about RPPT, the identification of key knowledge gaps, and specific recommendations to further build needed evidence. Discussion The emerging use of RPPT is an important tool for bridging gaps in access to care that impacts rural populations. However, to fully understand the value and effects of RPPT, new research is needed to fill the knowledge gaps identified in this report. Additionally, this report should help engage providers, payors, and policymakers interested in supporting evidence-informed RPPT practice, policy, and payment, with the ultimate aim of improving access to health care and health status of rural communities in the United States and worldwide.
Cigarette smoking and mitochondrial dysfunction in peripheral artery disease
Authors: Guo Michelle , McDermott Mary M , Dayanidhi Sudarshan , Leeuwenburgh Christiaan , Wohlgemuth Stephanie , Ferrucci Luigi , Peterson Charlotte A , Kosmac Kate , Tian Lu , Zhao Lihui , Sufit Robert , Ho Karen , Criqui Michael , Xu Shujun , Zhang Dongxue , Greenland Philip 
Published: December 2022

Background: This study evaluated the association of smoking with mitochondrial function in gastrocnemius muscle of people with peripheral artery disease (PAD). Methods: Participants were enrolled from Chicago, Illinois and consented to gastrocnemius biopsy. Mitochondrial oxidative capacity was measured in muscle with respirometry. Abundance of voltage-dependent anion channel (VDAC) (mitochondrial membrane abundance), peroxisome proliferator-activated receptor-γ coactivator (PGC-1α) (mitochondrial biogenesis), and electron transport chain complexes I–V were measured with Western blot. Results: Fourteen of 31 people with PAD (age 72.1 years, ABI 0.64) smoked cigarettes currently. Overall, there were no significant differences in mitochondrial oxidative capacity between PAD participants who currently smoked and those not currently smoking (complex I+II-mediated oxidative phosphorylation: 86.6 vs 78.3 pmolO2/s/mg, respectively [ p = 0.39]). Among participants with PAD, those who currently smoked had a higher abundance of PGC-1α ( p < 0.01), VDAC ( p = 0.022), complex I ( p = 0.021), and complex III ( p = 0.021) proteins compared to those not currently smoking. People with PAD who currently smoked had lower oxidative capacity per VDAC unit (complex I+II-mediated oxidative phosphorylation [137.4 vs 231.8 arbitrary units, p = 0.030]) compared to people with PAD not currently smoking. Among people without PAD, there were no significant differences in any mitochondrial measures between currently smoking ( n = 5) and those not currently smoking ( n = 63). Conclusions: Among people with PAD, cigarette smoking may stimulate mitochondrial biogenesis to compensate for reduced oxidative capacity per unit of mitochondrial membrane, resulting in no difference in overall mitochondrial oxidative capacity according to current smoking status among people with PAD. However, these results were cross-sectional and a longitudinal study is needed.
Pregnancy in women with cystic fibrosis and diabetes: An audit of outcomes at two tertiary obstetric hospitals in Australia in the pre-cystic fibrosis transmembrane conductance regulator modulator era
Authors: Davidson Sarah J , France Megan , Callaway Leonie K , Lust Karin , Chambers Daniel , Hopkins Peter , Bell Scott C , Burr Lucy , Keating Rebecca , Barrett Helen L 
Published: December 2022

Background Pregnancy in women with cystic fibrosis (CF) is becoming more common. Long-term metabolic issues such as diabetes are also becoming more common and have potentially important impacts on pregnancy outcomes. This study aimed to assess the impact of diabetes on pregnancy outcomes for women with CF. Methods We undertook a retrospective chart audit of pregnancies to women with CF at the two tertiary obstetric hospitals in Southeast Queensland associated with CF and transplant management clinics between 2006 and 2016. Results A total of 38 pregnancies among 26 women were identified. Four women (five pregnancies) had cystic fibrosis-related diabetes (CFRD) diagnosed prior to pregnancy, and 12 women (15 pregnancies) developed gestational diabetes (GDM) complicating pregnancy. CFRD and GDM were associated with higher rates of delivery complications, prematurity, and the need for neonatal intensive care unit admission. Conclusion Diabetes is common during pregnancy in women with CF and impacts pregnancy outcomes.
Efficacy and safety of high-dose esomeprazole and amoxicillin dual therapy versus bismuth-containing quadruple therapy for Helicobacter pylori infection: a multicenter, randomized controlled clinical trial
Authors: Mei Hao , Guo Yan , Zhao Jing-Tao , Yang Jun , Sun Wen-jing , Zhang De-kui , He Ping , Shi Gang , Su Na-yun , Han Ran , Lan Chun-Hui 
Published: December 2022

Background: A high-dose proton pump inhibitor (PPI)-amoxicillin dual therapy has been investigated for treatment of patients with Helicobacter pylori ( H. pylori) infection. Currently, the efficacy of this dual therapy remains inconclusive, with controversial findings from various single-center clinical trials. Objectives: To assess the efficacy and safety of high-dose dual therapy (HDDT) compared with the bismuth-containing quadruple therapy (BQT) in treatment-naive patients with H. pylori infection. Design: A multicenter, open-label, randomized controlled clinical trial. Methods: Three hundred and forty treatment-naïve patients with H. pylori infection were prospectively recruited from seven participating hospitals. The enrolled patients were randomized into one of two treatment groups: the HDDT group (esomeprazole, 20 mg four times daily; amoxicillin, 750 mg four times daily) and the BQT group (esomeprazole, 20 mg, twice daily; bismuth potassium citrate, 600 mg, twice daily; amoxicillin, 1 g, twice daily; metronidazole, 400 mg, four times daily). The primary outcome was eradication rate, and secondary outcomes were safety and patient compliance. Results: The eradication rates in the HDDT group versus the BQT group were 86.47% versus 87.06% on intention-to-treat (ITT) analysis, 91.88% versus 92.50% on modified ITT (MITT) analysis, and 91.77% versus 93.04% on per-protocol (PP) analysis, with no significant differences between the two groups. The patient compliance rates in the HDDT group versus the BQT group were 97.02% versus 95.86%, and no significant difference was found between the two groups. Notably, the HDDT group exhibited significantly lower incidence in the drug-induced adverse events (AEs) compared to the BQT group (16.67% versus 47.94%). Conclusion: HDDT is equally efficacious in eradicating H. pylori infection and resulted in good patient compliance and safety compared with BQT. These findings provide evidence in support of HDDT as a first-line treatment for H. pylori infection. Registration: This clinical trial was registered at The Chinese Clinical Trial Registry (trial registration number: ChiCTR2000039096).
Ustekinumab is associated with superior treatment persistence but not with higher remission rates versus vedolizumab in patients with refractory Crohn’s disease: results from a multicentre cohort study
Authors: Bacsur Péter , Matuz Mária , Resál Tamás , Miheller Pál , Szamosi Tamás , Schäfer Eszter , Sarlós Patrícia , Iliás Ákos , Szántó Kata , Rutka Mariann , Bálint Anita , Milassin Ágnes , Fábián Anna , Bor Renáta , Szepes Zoltán , Molnár Tamás , Farkas Klaudia 
Published: December 2022

Background: Treatment with antitumor necrosis factor alpha (anti-TNF-α) is safe and effective as first-line therapy; however, its efficacy is limited due to primary nonresponse (PNR) and secondary loss of response (LOR), resulting in treatment discontinuation in approximately 40%–50% of cases. Vedolizumab (VDZ) and ustekinumab (UST) therapies could be good alternatives in patient with anti-TNF failure; however, no head-to-head randomized comparison of these drugs as second- or third-line treatments has been made. Objectives: This study aimed to assess the treatment persistence and comparative effectiveness of UST and VDZ in patients with refractory Crohn’s disease (CD). Design: In this nationwide retrospective study, patients with CD on UST or VDZ maintenance therapy were enrolled. Clinical data at baseline, after induction, and at week 52 were obtained. Methods: Clinical and biochemical activities as well as corticosteroid-free remission (SFR) rates were assessed, while concomitant medications, comorbidities, hospitalizations, and surgeries were recorded during the follow-up to detect any predictors. Results: A total of 161 UST- and 65 VDZ-treated patients completed the follow-up. No significant difference in clinical or biochemical remission rates was observed after induction between the two treatment groups; however, clinical remission rate at week 52 was higher in UST group. UST showed superior drug persistence than VDZ (86.5%, 57.9%, p < 0.0001). The drug type was predictive of clinical SFR at week 52 [ p = 0.011, odds ratio (OR) = 2.39 with UST]. Drug failure rates were higher for VDZ than those for UST (PNR rates: 21.54% and 4.97%, respectively, p < 0.001, OR = 8.267, p = 0.001). LOR and escalations were more common during UST treatment (61.5% versus 36.9%, p < 0.001; 64.2% versus 23.1%, p < 0.001). Hospital and surgical admission rates did not differ significantly. Only one adverse event occurred with VDZ at week 20, which led to drug cessation. Conclusions: VDZ and UST were safe and effective for treating patients with CD in whom anti-TNF therapy failed. UST showed superior drug persistence than VDZ, but dose escalation was more frequent. Biologicals used in lower treatment lines resulted in better drug persistence.
Eltrombopag increases the hematopoietic supporting ability of mesenchymal stem/stromal cells
Authors: Muntión Sandra , Preciado Silvia , Sánchez-Luis Elena , Corchete Luis , Díez-Campelo María , Osugui Lika , Martí-Chillón Gerardo-Javier , Vidriales María-Belén , Navarro-Bailón Almudena , De Las Rivas Javier , Sánchez-Guijo Fermín 
Published: December 2022

Background: Eltrombopag (EP) is a small molecule that acts directly on hematopoietic stem cells (HSCs) and megakaryocytes to stimulate the hematopoietic process. Mesenchymal stem/stromal cells (MSCs) are key hematopoietic niche regulators. Objectives: We aimed to determine whether EP has any effect on MSC function and properties (especially on their hematopoietic-supporting ability) and if so, what changes (e.g. genome-wide transcriptomic alterations) are induced in MSC after EP treatment. Design/Methods: MSCs were isolated from 12 healthy donors and treated with 15 µM and 50 µM of EP for 24 h. The toxicity of the drug on MSCs and their differentiation ability were analyzed, as well as the transcriptomic profile, reactive oxygen species (ROS) and DNA damage and the changes induced in the clonogenic capacity of HSCs. Results: The results show that EP also modifies MSC functions, decreasing their adipogenic differentiation, increasing the expression of genes involved in hypoxia and other pathways related to oxygen homeostasis, and enhancing their ability to support hematopoiesis in vitro. Conclusion: Our findings support the use of EP in cases where hematopoiesis is defective, despite its well-known direct effects on hematopoietic cells. Our findings suggest that further studies on the effects of EP on MSCs from patients with aplastic anemia are warranted.
Introducing a Clinical Summary Template From the Adult Day Center to Support Decision Making by Primary Care Providers
Authors: Zhong Jie , Boafo Jonelle , Sadarangani Tina R. 
Published: December 2022

Introduction: CareMOBI (Mhealth for Organizations to Bolster Interconnectedness) is a mobile application designed to facilitate information exchange between primary care providers (PCPs) and adult day centers (ADCs). A key function of CareMOBI is to synthesize information collected outside of the provider’s office (ie,: in the ADC or at home) and distill the most relevant data points into an exportable clinical summary that can help inform clinical decision making by the PCP with information from outside providers who are not formally embedded within health systems. In this study, we used a qualitative approach to understand the acceptability and utility of the clinical summary template within CareMOBI. Methods: Purposive sampling, followed by snowball sampling, was used to recruit PCPs from a variety of primary care practice settings (i.e. home-based, academic). Semi-structured interviews were conducted virtually to elicit feedback on the user-experience after interaction with a prototype template. Interviews were recorded, transcribed, and analyzed using content analysis. Results: Our sample (n = 10) consisted of physicians and nurse practitioners in a variety of settings. Feedback suggested that the summary template facilitates interdisciplinary, bidirectional, succinct, and relevant information exchange across care teams. The summary template effectively integrates observations and assessments from team members, centralizes them, and allows PCPs to hone in on the most salient components to inform clinical decision making for the geriatric patient. The summary gave PCPs “live texture” about what was happening outside the office and represented a significant improvement over other methodologies of information exchange. Prior to implementation into clinical practice, several refinements are necessary based on feedback including integration into the PCP’s workflow. Conclusions: The template was viewed by PCPs as a concise and actionable record, in contrast to current communication which is characterized as “bloated”—containing too many pages on nonessential information. The summary could potentially save PCP’s time in locating and analyzing historical data to enable rapid patient assessment and prompt more ready and informed action.