bluuebunny/crossref_metadata_2025_split huggingface dataset:
Radical intraoperative thermal ablation of osteogenic sarcoma: clinical observation
Authors: Anisenya I. I. , Sitnikov P. K. , Pakhmurin D. O. , Pakhmurina V. V. , Vasiliev N. V. , Zelchan R. V. , Bogoutdinova A. V. , Tabakaev S. A. , Khakimov Kh. I. , Mitrichenko A. D. 
Published: September 2023

Introduction. Difficult diagnosis, aggressive progression, and absence of an increase in treatment effectiveness (especially in patients with osteosarcoma and Ewing sarcoma) make malignant tumors of the bones a significant medical problem. Use of traditional therapy methods is often associated with development of drug resistance and frequent recurrences. Therefore, there is a need for new treatment strategies and overcoming of the limitations of traditional methods through their improvement, combination or substitution to achieve higher survival, lower recurrence rate, and wider availability for patients with bone tumors.Aim. To present a clinical observation of the use of a new method of radical intraoperative thermal ablation for bone tumors, assess exposure tolerance, long-term oncological and functional results.Clinical observation. This article presents a clinical case of the use of a new radical treatment method for a patient with tibial osteosarcoma who underwent intraoperative thermal ablation using a new domestic complex of local hyperthermia “Phoenix-2”.Results. A session of intraoperative thermal ablation was performed in the operating room under anesthesia directly in the wound for 48 minutes. Access to the tumor-affected bone was performed with the standard oncological approach (en-block), the bone was not transected or removed. A constant heating mode of 90 °С was used, assuming a gradual increase in temperature. Thus, 60 °С reached 20 minutes, and the temperature at the end of high-temperature exposure was 78 °С (inside the medullary canal). The operation time was 2 hours 30 minutes. The postoperative period proceeded without complications. After 38 months of follow-up, examinations did not reveal any recurrence or progression in the patient.Conclusion. The technique of radical intraoperative thermal ablation using a local hyperthermia complex Phoenix-2 is effective and allows to widen the toolkit of treatment methods for patients with bone tumors. It can serve as an alternative or addition to organ-preserving surgical treatment without costly reconstruction stages.
Cultivation of Character Values in Choukai Kaiwa Shokyu Kohan Course
Authors: Asrini Dwi Puji 
Published: September 2023

Students who engage in the study of foreign languages may face the potential risk of experiencing a loss of their personal identity, as their sense of pride becomes intertwined with the cultural heritage of the country associated with the language they are acquiring. Students may also experience a decline in their sense of patriotism and attachment to their nation. Consequently, it is imperative to make concerted endeavors to incorporate character attributes within the curriculum provided. The present study employs a qualitative research approach that utilizes descriptive research methods. The individuals involved in this research were students enrolled in the Choukai Kaiwa Shokyu Kohan Course, which is a component of the Japanese Language Education Study Program. Data collection involved the utilization of many methods, including observation, interviews, documentation, and field notes. The character values have been derived from the Ministry of Education and Culture (2017). The data was analyzed to ascertain the character values that can be associated with the course themes and to classify the obstacles to fostering these character qualities. The Choukai Kaiwa Shokyu Kohan course offers the opportunity for the cultivation of several character traits, such as religiousness, honesty, discipline, industriousness, creativity, independence, curiosity, patriotism, sociability, and responsibility. The learning flow to teach character attributes consists of several steps: mite kangaeru (observe and think), miru-kiku-ittemiru (see, hear, ask, and experience), kiite kizuku (listen and notice), ruuru o hakensuru (analyze rules), tsukatte miru (practice and apply), Can Do chekku (check for proficiency), and seikatsu to bunka (life and culture). One of the challenges encountered in cultivating character values is the limited capacity of teachers to assess all student groups during the process of integrating them into discussion exercises. Additionally, it is worth noting that only a subset of character values may be effectively evaluated through assignments.
Increasing the Efficiency of Cattle Bone Ash P Fertilization with Nano Technology and Its Effect on the Growth and Yield of Shallots
Authors: Hidayat Taufiq , Widyastuti Titiek , Wulandari Fetty Nur Cahyati , Dewi Sukuriyati Susilo 
Published: September 2023

The study investigates the efficacy of nano-sized cattle bone ash as an alternative phosphorus source for shallot cultivation, aiming to reduce dependence on mined phosphate rock. The experimental study was arranged in a 4 x 3 factorial Completely Randomized Design. The first factor was the recommended dose of P fertilizer, consisting of 100%, 80%, 60%, and 40%. The second factor was using nano cattle bone ash as a foliar application, applied 3, 4, and 5 times. The observation was made on the plant growth and yield of shallot. Data analysis was conducted with an ANOVA and continued with the DMRT. The results showed no interaction effect of the dose of P fertilizer and the frequency of spraying nano cattle bone ash on the growth and yield of shallots. The application of P fertilizer at 40% of the recommended dose could already produce shallots that were the same as the application of P fertilizer according to the recommended dosage. The spraying frequency of three times was able to provide high shallot yields. In the future, it is expected that spraying cow bone ash with nanotechnology can be applied three times with a 40% recommended dose of P to increase fertilization efficiency.
Comparative evaluation of the efficacy of clinical diagnosis, conventional radiography and ultrasonography (usg) in the diagnosis of odontogenic lesions – A short study
Authors: Giri Debanti , Agarwal Nitin , Sinha Abhishek , Iqbal Haider 
Published: September 2023

Several imaging techniques are adopted by clinicians in day-to-day practice amongst which clinical diagnosis and conventional radiography are been relied on mostly. However, owing to the high radiation exposure and other shortcomings of computed tomography or MRI, Ultrasonography has emerged as an effective method of choice for diagnosis. 40 patients were selected for the study among the patients visiting the department at the Department of Dentistry, NRS Medical College and Hospital. All the patients of the study group were examined clinically and radiographically followed by Ultrasonography and Color Doppler was performed by ultrasound machine (SIEMENS- G50) Collected data were analysed by means of statistical software Statistical Package for Social Sciences STATA-15. ANOVA test was done to compare the Radiographical diagnosis and USG, further association has been checked between two variables.It was observed that USG diagnosis had a sensitivity and specificity of 100% & 86.9% respectively with an accuracy of 98.6% compared to clinical diagnosis & had a sensitivity and specificity of 100% & 86.9% respectively with an accuracy of 98.6% compared to radiographic diagnosis. Real-time USG with high frequency transducers can suggestively enhance the assessment of various head and neck pathological lesions and can thus be used as a supplement in clinical examination of patients to deduce a confirmatory diagnosis.
Akut iskemik inme mortalitesinin bir belirleyicisi olarak serum glukoz potasyum oranının değerlendirilmesi
Authors: MERMER Aydın , AKINCI EKİNCİ Nuran 
Published: September 2023

Amaç: Bu çalışma, akut iskemik inme (AIS) hastalarında yapılan serum glukoz/potasyum oranındaki (GPR) değişikliklerin hasta yönetiminin daha hızlı ve etkin bir şekilde yapılmasına etkisini göstermeyi amaçlamaktadır.
Gereç ve Yöntemler: AIS nedeniyle mekanik trombektomi uygulanan hastaların hematolojik ve biyokimyasal parametreleri retrospektif olarak incelendi. Hastalar non-survivor (yaşamayanlar) ve survivor (yaşayanlar) olmak üzere iki gruba ayrıldı. GPR hesaplandı ve mortaliteyi tahmin etme yetenekleri gruplar arasında istatistiksel olarak değerlendirildi.
Bulgular: Survivor grupta 131 ve non-survivor grupta 42 olmak üzere toplam 173 hasta analiz edildi. Non-survivor grubunda glukoz ve GPR, survivor grubuna göre istatistiksel olarak anlamlı şekilde yüksekti (p
Quality improvement of rubber seed meal diet for Nile tilapia with amino acid supplemetation
Authors: Yusuf Didi Humaedi , Suprayudi Muhammad Agus , Jusadi Dedi 
Published: September 2023

ABSTRACT This experiment was conducted to improve the quality of rubber seed meal fermented using sheep rumen liquor based diet (RSMF) with amino acid supplementation for Nile tilapia Oreochromis niloticus. This experiment consisted of five treatments with three replications. The treatments were 0% protein from RSMF as control; 50% RSMF; 50% RSMF with lysine; 75% RSMF and 75% RSMF with lysine. Tilapia with an initial body weight of 6.29±0.12 g were reared for 40 days and the fish were fed three times daily at satiation level (8.00 am, 12.00 pm and 16.00 pm). The data were statistically analysed by using one-way analysis of variance (ANOVA) using software SPSS version 16.0 at 95% (p<0.05) confidence interval and Tukey test for the post hoc test. The results showed that the addition of lysine in the 75% RSMF diets could increased final weight, but did not significantly different to protein efficiency ratio (PER), decreased feed convertion ratio (FCR) and biochemical body composition. The data indicated that quality of 75% RSMF could improved after lysine supplementation, but still lower than using 50% RSMF and soybean meal as protein source. Keywords: amino acid supplementation, Oreochromis niloticus, rubber seed meal ABSTRAK Penelitian ini dilakukan untuk meningkatkan kualitas pakan dengan tepung bungkil biji karet yang difermentasi dengan cairan rumen domba (TBBKF) melalui suplementasi asam amino untuk ikan nila Oreochromis niloticus. Penelitian ini terdiri atas lima perlakuan dengan tiga ulangan. Perlakuan terdiri atas 0% protein dari TBBKF sebagai kontrol; 50% TBBKF; 50% TBBKF + Lisin; 75% TBBKF dan 75% TBBKF + lisin. Ikan nila dengan bobot awal 6,29±0,12 g dipelihara selama 40 hari dan pemberian pakan dilakukan tiga kali sehari hingga sekenyangnya (08.00, 12.00 dan 16.00 WIB). Data dianalisis menggunakan analisis sidik ragam (ANOVA) dengan menggunakan software SPSS 16.0 dan diuji lanjut menggunakan uji Tukey. Hasil penelitian menunjukkan bahwa penambahan lisin pada pakan 75% TBBKF meningkatkan bobot tubuh ikan akhir, tetapi tidak berpengaruh signifikan terhadap rasio efisiensi protein (PER), rasio konversi pakan (FCR) dan komposisi biokimia tubuh ikan nila. Hasil penelitian ini menunjukkan bahwa kualitas protein 75% TBBKF meningkat setelah suplementasi lisin, tetapi masih lebih rendah dibandingkan dengan penggunaan 50% TBBKF dan tepung kedelai sebagai sumber protein. Kata kunci: suplementasi asam amino, Oreochromis niloticus, tepung biji karet
The growth and physiological responses of tambaqui Colossoma macropomum fed on the high dose of clove oil-supplemented diet
Authors: Puteri Andi Tiara Eka Diana , Jusadi Dedi , Nuryati Sri 
Published: September 2023

ABSTRACT In this study, tambaqui Colossoma macropomum juvenile were given feed supplemented with clove oil Syzygium aromaticum at a dose of 0 and 100 mg/100 g diet. This study purposed to assessment the effect of clove oil supplementation at high dose (100 mg/100 g diet) on growth performance and health status of freshwater tambaqui. As many as 25 fishes with initial body weight 7.62±0.44 g maintained in 15 aquariums for 45 days. Each treatment consisted of three replications. Data were analyzed by t-test. The results showed that tambaqui growth performance on both treatments were not significantly different. However, supplementation of high doses 100 mg clove oil/100 g diet showed reduce on the blood parameters and declining the abundant of intestinal microflora in tambaqui gut, but the types seen more diverse. The observation of fish liver histology showed that hepatocyte cells in the treatment of 100 mg clove oil become smaller and dense compared with 0 mg clove oil treatment. The use of high doses of clove oil does not interfere with the tambaqui growth performance despite the downturn in the physiological responses were observed. Keywords: clove oil, Syzygium aromaticum, Colossoma macropomum, growth performance ABSTRAK Di dalam penelitian ini, benih ikan bawal tawar Colossoma macropomum dipelihara dengan pemberian pakan yang ditambah minyak cengkeh Syzygium aromaticum pada kadar 0 dan 100 mg/100 g pakan. Tujuannya untuk melihat pengaruh penambahan minyak cengkeh di dalam pakan pada dosis tinggi (100 mg/100 g pakan) terhadap performa pertumbuhan dan respons fisiologis ikan bawal. Sebanyak 25 ekor ikan bawal dengan bobot individu awal 7,62 ± 0,44 g dipelihara pada 15 akuarium selama 45 hari. Data yang diperoleh dianalisis dengan uji komparasi t-test antar dua perlakuan dengan tiga ulangan. Hasil penelitian menunjukkan bahwa tidak ada pengaruh dari kedua perlakuan terhadap parameter pertumbuhan. Namun, pemberian pakan yang mengandung minyak cengkeh dosis tinggi 100 mg/100 g pakan mempengaruhi respons fisiologis berupa rendahnya kisaran nilai gambaran darah serta menurunnya jumlah mikroflora di usus ikan bawal, meski jenisnya lebih beragam. Hasil pengamatan histologi hati ikan pada perlakuan 100 mg minyak cengkeh menunjukkan bahwa sel hepatosit berukuran lebih kecil dan terlihat rapat dibandingkan dengan perlakuan 0 mg minyak cengkeh. Penggunaan minyak cengkeh dosis tinggi tidak menganggu performa pertumbuhan ikan bawal meskipun terjadi penurunan pada respons fisiologis yang diamati. Kata penting: minyak cengkeh, Syzygium aromaticum, Colossoma macropomum, performa pertumbuhan
Transferability of the Structure-Property Relations from Laser Pretreated Metal-Polymer Joints to Aluminum—CFRP Hybrid Joints
Authors: Freund Jonathan , Lützenkirchen Isabel , Löbbecke Miriam , Delp Alexander , Walther Frank , Wu Shuang , Tröster Thomas , Haubrich Jan 
Published: September 2023

The transferability of structure-property relationships for laser-pretreated metal adhesive joints to laser-pretreated metal – carbon fiber reinforced plastic (CFRP) bonds is investigated. Single-lap shear tests were performed on hybrid AW 6082-T6 – CFRP specimens pretreated with the same pulsed laser surface parameter sets on the metal surface as previously tested AW 6082-T6 – E320 metal adhesive joints. The fracture surfaces were characterized to determine the type of failure and elucidate differences and commonalities in the link between surface structures and single-lap shear strengths. Digital image analyses of the hybrid specimens fractured surfaces were used to quantify remaining CFRP fragments on the metallic joint side. The results indicate that high surface enlargements and the presence of undercut structures leads to single-lap shear strengths exceeding 40 MPa and 35 MPa for unaged and aged hybrid specimens respectively. While for the metal-polymer joints the trend from high strength to weakly bonded specimens was largely continuous with the degree of surface structuring, hybrid metal – CFRP joints exhibit a drastic drop in joint performance after aging if the laser-generated surface structures are less pronounced with low surface enlargements and crater depths. Surface features and hydrothermal aging determine whether the specimens fail cohesively or adhesively.
Integration of Seismic Poisson Impedance Data with Real-Time Geomechanics and Real-Time 3D Ultradeep Resistivity Inversion Enabled New Opportunities in Developed Field: Case Study from Kuwait
Authors: Abdulkarim Anar , Kharitonov Alexander , El Gezeeri Taher M. , Al Haddad Mohammed , Halawah Yousif Ahmad , Sabea Salem Al 
Published: September 2023

Summary
The Wara sandstone reservoir in the Minagish field of Kuwait Oil Company is a complex deposition of a typical pro-deltaic environment consisting of shaly-silty sandstone sequences, referenced as W7–W1. Three of these sequences (W6, W5, and W3) were expected in the case study well. The objective was to set a 9⅝-in. casing at the top of W6 and then drill through the Wara sequences to connect all of them and land and drill the lateral section within W3.
The W6 sequence is typically the primary target in the Wara formation, being thick and consistent throughout the field. The next logical step in developing the Wara reservoir was to study and investigate the minor W5 and W3 members. Due to poor correlation of W5 and W3 channels in offset wells, the geological target was selected based on seismic Poisson impedance (PI). Historically, targeting the Wara formation occasionally resulted in multiple sidetracks due to drilling challenges. A real-time geomechanics service was used to overcome drilling challenges, and real-time 3D ultradeep resistivity inversion was implemented to optimize the well placement.
An extensive predrilling study for geomechanical and ultradeep resistivity inversion modeling helped to develop a road map for an optimal and safe well-construction process. The study showed that use of real-time 3D ultradeep azimuthal resistivity (UDAR) inversion would help to optimize the well placement and maximize the sweet-zone exposure. The original well design, mud properties, and drilling parameters were modified based on the geomechanical study. Additionally, real-time geomechanics services were used to monitor and control the drilling process to follow the road map, which helped to avoid drilling issues, geostop at the W6 channel, and finally to run the casing smoothly. Real-time 3D ultradeep resistivity mapping in the lateral section helped the operator to drill through W6 and W5, land precisely, and drill the lateral in the W3 channel, which was well developed, as expected from seismic PI analysis. Formation evaluation of the lateral section showed an average porosity of 24 p.u., water saturation of 11%, and up to 3 darcies/cp mobility.
The application of real-time 3D ultradeep resistivity inversion helped to triple the planned formation exposure and discover a geometric extension of the above deposited channels (W6 and W5), which will help for future field development. The flow test showed the highest production rates from W3 in the field. The integrated approach described above was recommended to be utilized for all future Wara wells.
Gene-disease association: pathogenic potential/pathogenic feature assessment
Authors: Bian Wen-Jun , Wang Jie , Li Bin , Gao Liang-Di , Zhang Wen-Jun , Liang Xiao-Yu , Liu Liu , Fan Cui-Xia , Yan Li-Min , Liu Li-Hong , Jiang Mi , Liang De-Hai , Wang Juan , Ye Zi-Long , Tang Xue-Qing , Li Huan , Luo Sheng , Shen Nan-Xiang , Su Tao , Liu Xiao-Rong , He Na , Shi Yi-Wu , Yi Yonghong , Liao WeiPing 
Published: September 2023

Abstract
Determining gene-disease associationsis an essential task but a major challenge of genetic studies. It is also the precondition for evaluating the pathogenicity of variants. Considering what determines the gene-disease association and which clinical-genetic features reflect the gene-disease association, we proposed a pathogenic potential and pathogenic feature assessment (PPA) system to evaluate the gene-disease association. In addition to case/variant number, PPA evaluates the clinical-genetics evidence from phenotypic specificity, inheritance pattern, genotype-phenotype correlation, and submolecular implication of variants, which represent the pathogenic feature of the gene. PPA refers to experimental evidence directly related to gene-disease associations, including gene expression and knockout, and the functional consequencesof variants. We collected data on all potentially functioning genes (19,711) and assessed those with available clinical data, and 3,623 genes were evaluated as “pathogenic”/“possibly pathogenic”. The pathogenic features of genes were summarized, providing critical information for evaluating the pathogenicity of variants. PPA considers the genetic dependent feature that differs in each gene and determines the pathogenicity of genes and evaluates whether (pathogenic potential) and how (pathogenic feature) a gene is associated with a disease and avoidsbias associated with special genotype or inheritance, potentially being a framework in future studies in defining the gene-disease association.
Combinatorial Analysis of the Exponential Map for Time-Evolution Operator
Authors: CEYLAN Ali Mert , AYTAÇ Vecdi 
Published: September 2023

Abstract
In this study, we present a novel formalization for exponential approx-imation. This formalization is for discrete analysis of continuous time-dependent perturbation operator of quantum mechanics, com-pared to multiplying exponentials. This leads us to Galton arrays for better representation and algebraic operations over exponential mul-tiplications. Rotations on Galton arrays allow us to perform various algebraic operations and intuitively explain commutative and non-commutative operators equality in exponential approximations. Pro-posed algebraic operations over Galton arrays will provide an easier understanding and a novel way to formalize and visualize multi-plying exponentials. But most importantly, it focused on the time-evolution operator to be written in the proposed formalization of time-ordered multiplication of exponentials with noncommuting operators.
In-depth proteome analysis of brain tissue from Ewsr1 knockout mouse by multiplexed isobaric tandem mass tag labeling
Authors: Han Dohyun , Ryu Hoon , Jung Jin Woo , Kim Hyeyoon , Park Joonho , Woo Jongmin , Jeon Eunji , Lee Geeeun , Park Minseo , Kim Sarang , Seo Ho Seok , Cheon Seongmin , Dan Kisoon , Lee Junghee 
Published: September 2023

Abstract
EWS RNA binding protein 1 (EWSR1) is a multifunctional protein whose epigenetic signatures contribute to the pathogenesis of various human diseases, such as neurodegenerative disorders, skin development, and tumorigenic processes. However, the specific cellular functions and physiological characteristics of EWSR1 remain unclear. In this study, we used quantitative mass spectrometry-based proteomics with tandem mass tag labeling to investigate the global proteome changes in brain tissue in Ewsr1 knockout and wild-type mice. From 9115 identified proteins, we selected 118 differentially expressed proteins, which is common to three quantitative data processing strategies including only protein level normalizations and spectrum-protein level normalization. Bioinformatics analysis of these common differentially expressed proteins revealed that proteins up-regulated in Ewsr1 knockout mouse are mostly related to the positive regulation of bone remodeling and inflammatory response. The down-regulated proteins were associated with the regulation of neurotransmitter levels or amino acid metabolic processes. Collectively, these findings provide insight into the physiological function and pathogenesis of EWSR1 on protein level. Better understanding of EWSR1 and its protein interactions will advance the field of clinical research into neuronal disorders. The mass spectrometry proteomics data have been deposited to the ProteomeXchange Consortium via the PRIDE partner repository with the dataset identifier PXD026994.