bluuebunny/crossref_metadata_2025_split huggingface dataset:
Molecular profiling of pre- and post-treatment pediatric high-grade astrocytomas reveals acquired increased tumor mutation burden in a subset of recurrences
Authors: Wood Matthew D. , Beadling Carol , Neff Tanaya , Moore Steve , Harrington Christina A. , Baird Lissa , Corless Christopher 
Published: September 2023

AbstractDiffuse gliomas are a heterogeneous category of primary central nervous system tumors. Due to their infiltrative growth precluding complete surgical resection, most diffuse high-grade gliomas are treated with adjuvant chemotherapy and radiation. Recurrent/progressive diffuse gliomas may show genetic differences when compared to the primary tumors, giving insight into their molecular evolution and mechanisms of treatment resistance. In adult-type diffuse gliomas with or without isocitrate dehydrogenase gene mutations, tumor recurrence/progression can be associated with mutations in genes encoding DNA mismatch repair proteins, leading to a dramatic increase in tumor mutation burden. This phenomenon is closely linked to treatment with the DNA alkylating agent temozolomide, a mainstay of adult diffuse glioma chemotherapeutic management. Post-treatment mismatch repair deficiency and acquired high tumor mutation burden is relatively unexplored in pediatric patients who have recurrent high-grade gliomas. Here, we report a molecular and histological analysis of an institutional cohort of eleven pediatric patients with paired initial and recurrent high-grade astrocytoma samples with intervening temozolomide treatment. We identified three cases with evidence for increased tumor mutation burden at recurrence, including two cases of diffuse hemispheric glioma H3 G34-mutant (one previously reported). We also show that molecular analysis by next-generation DNA sequencing and DNA methylation-based profiling enabled an integrated diagnosis per 2021 World Health Organization criteria in 10 of 11 cases (91%). Our findings indicate that increased tumor mutation burden at post-treatment recurrence is relevant in pediatric-type diffuse high-grade gliomas. Diffuse hemispheric glioma H3 G34-mutant may be particularly susceptible to this phenomenon.
Non-O1/O139 Vibrio cholerae causes severe intestinal disease in bullfrogs (Rana catesbeiana)
Authors: Liao Wenyu , Wei Dongdong , Liu Mingzhu , Ke Ke , Shi Deqiang , Li Bingzheng , Huang Shuaishuai , Jiang Jianbo , Yu Qing , Li Pengfei 
Published: September 2023

AbstractBullfrogs (Rana catesbeiana) are amphibians with high economic value, but in recent years, bullfrog farming has encountered serious threats of bacterial diseases, and the “bullfrog economy” is facing a continuous decline. In this study, the dominant strain was isolated from diseased bullfrogs in a bullfrog farm in Nanning, Guangxi, and based on its morphological, physiological, and biochemical characteristics and analysis of 16S rRNA gene sequences, the strain was identified as a non-O1/O139 group Vibrio cholerae and named TC1. Three virulence factors were identified in this strain, including hemolysin, outer membrane protein, and toxin-coregulated pili. Drug susceptibility testing showed that the strain resisted gentamicin, florfenicol, nitrofural, oxytetracycline, neomycin, penicillin, amoxicillin, doxycycline, and sulfamonomethoxine. The results of artificial infection experiments showed that TC1 caused serious pathologies such as abdominal swelling and anal prolapse in bullfrogs, especially severe intestinal bleeding. Histopathological observations revealed that the bullfrog intestine exhibited obvious pathological lesions. These results provide an essential epidemiological basis for controlling V. cholerae infections in aquatic animals and demonstrate the promise of bullfrogs as an amphibian model for studying the pathogenesis of V. cholerae.
Successful resection of a hypervascular paravertebral solitary fibrous tumor of pleura preserving the artery of Adamkiewicz, which was detected on preoperative angiography
Authors: Manabe Takehiko , Mori Masataka , Kanayama Masatoshi , Kuwata Taiji , Takenaka Masaru , Kuroda Koji , Fukumitsu Satoshi , Murakami Yu , Aoki Takatoshi , Nakayama Toshiyuki , Tanaka Fumihiro 
Published: September 2023

Abstract
Background
Solitary fibrous tumor of the pleura is rarely observed, accounting for 1% of all mediastinum tumors. There have been only a few reports of preoperative embolization for hypervascular tumors around the artery of Adamkiewicz (AKA). We report a rare case of solitary fibrous tumor for which transcatheter embolization was successfully performed before surgical resection.

Case presentation
A 66-year-old woman with sudden-onset back pain was referred to our hospital for the evaluation of a left intrathoracic abnormal shadow on chest X-ray. Preoperative computed tomography (CT) showed a large, posterior mediastinal, paravertebral, and well-demarcated mass with high contrast enhancement and significant vascularization fed by the intercostal artery (ICA), measuring 8.1 × 7.6 × 6.4 cm. Therefore, solitary fibrous tumor, unicentric Castleman disease, or paraganglioma was included in the differential diagnosis. The patient underwent preoperative transcatheter arterial embolization followed by surgical extirpation. Thanks to the appropriate assessment of the anatomy, we could resect the tumor safely. The pathological diagnosis was solitary fibrous tumor of pleura.

Conclusions
We recommend preoperative transcatheter arterial embolization (TAE) for hypervascular tumors close to the AKA that may require surgical removal; to reduce intraoperative hemorrhage, the AKA should be accurately detected during surgery.
The Talk to Granny initiative: societies world-wide seek whole society approaches to mental health
Authors: Michel Janet , Pham-Tan Odile , Tanner Marcel 
Published: September 2023

There are nearly one billion people worldwide who suffer from some form of mental disorder. Of concern is that one in seven teenagers has a mental health issue and that pandemics such as COVID-19 precipitate mental health issues, while at the same time exacerbating pre-existing mental health conditions. The importance of mental health is increasingly being acknowledged. The inclusion of mental health in sustainable developmental goals (SDGs) is a case in point. One multi-country study revealed mental health as having taken the second spot as a health concern in most countries. Of utmost concern are findings that these waves of mental health issues we are currently seeing are not solely attributed to the pandemic. The rise in mental health issues has been associated with a rising trend of structural issues at the workplace for some time. At the same time, the health care workers, who are the supposed carers, are themselves burnt out, overworked and fighting the same battles of juggling parenthood, work pressures, insecurities and toxic work environments. In short, they too have not been spared from mental health issues. In our view, finding innovative means to address the mental health issue is an urgent task. The Organization for Economic Cooperation and Development (OECD) proposes a multi-sectoral integrated approach to mental health, going beyond mental health specialists, to include multiple actors and sectors from schools, teachers, line managers and community actors. As societies in Europe seek whole society approaches to mental health, we propose the “Talk to Granny” initiative. This proposal involves encouraging individuals to have conversations with their grandmothers, a free, tried and tested mutually beneficial resource generations have turned to in times of difficulties in most cultures
Prenatal testing - diagnostic possibilities in the 21st century with special emphasis on the diagnosis of genetic defects and heart defects
Authors: Tarsa Grzegorz , Ben Rhaiem Rami , Sudelska Katarzyna , Sawińska Zuzanna , Kępka Przemysław , Łokczewska-Bojar Aleksandra , Kuziemkowska Daria , Kuźma Jan , Skotalczyk Magdalena , Łącka-Majcher Anna 
Published: September 2023

Introduction: Prenatal diagnosis is a branch of medicine that deals with the detection of possible genetic and developmental abnormalities at the fetal life stage. Due to the rapid development of technology in recent decades, diagnostic capabilities at the prenatal stage have also changed their face.
Aim of the study: The aim of the study is to review the available scientific literature in order to systematize the current knowledge of prenatal diagnosis with particular emphasis on the diagnosis of genetic diseases and diagnosis of heart defects.
Results: Prenatal diagnosis is divided into invasive and non-invasive diagnostics. Non-invasive diagnostics include ultrasound, maternal blood biochemical tests and NIPT tests. Invasive diagnostics include tests such as amniocentesis and chorionic villus biopsy. Prenatal tests provide information on the risk of genetic diseases such as trisomy 21, 13 and 18 chromosome. In addition, serious structural heart defects such as tetralogy of Fallot are likely to be detected during prenatal diagnosis. Prenatal testing can also detect fetal heart rhythm abnormalities, which makes it possible to start treatment at an early stage. Modern ultrasound technology also allows 3D imaging, which can also provide valuable diagnostic information.
Summary: Prenatal diagnosis is a highly developed field of medicine that combines knowledge from various specialties. Thanks to prenatal diagnosis, it is possible to detect various abnormalities at an early stage of fetal life, which enables early treatment.
Femtosecond laser printing-assisted etching tailored hard and brittle micro-convex surface
Authors: Liu Yang , Huang Ji , Yin Bin , Ye Yunxia , Liang Misheng , Chen Xiaozhe , Wang Feifei , Zhang Jingjing , Dai Zijie 
Published: September 2023

We report a femtosecond laser print-assisted dry etching technology for high-efficiency, high-quality, and tailored fabricating of a micro-convex surface (MCS) on hard and brittle materials. Liquid ultraviolet curing adhesive (UVCA) was transferred from a donor substrate to a receiving substrate by femtosecond laser-induced forward transfer, and the transferred microdroplet spontaneously has a smooth surface under the action of surface tension. And then an MCS with a high-quality surface was formed on hard and brittle materials by UV curing and dry etching. The effects of laser parameters and receiving substrate surface free energy on MCS morphology were investigated. According to the variation of the numerical aperture, the two methods to change the morphology of the MCS were divided into independent/joint regulation of diameter and height. We showed that a hexagonal array containing a variety of MCS morphologies can be fabricated on a fused silica by setting the appropriate parameters. And the fabrication time of an MCS in a large-area array was only 1.1 s.
Scalable photonic integrated circuits for high-fidelity light control
Authors: Menssen Adrian J. , Hermans Artur , Christen Ian , Propson Thomas , Li Chao , Leenheer Andrew J. , Zimmermann Matthew , Dong Mark , Larocque Hugo , Raniwala Hamza , Gilbert Gerald , Eichenfield Matt , Englund Dirk R. 
Published: September 2023

Advances in laser technology have driven discoveries in atomic, molecular, and optical (AMO) physics and emerging applications, from quantum computers with cold atoms or ions, to quantum networks with solid-state color centers. This progress is motivating the development of a new generation of optical control systems that can manipulate the light field with high fidelity at wavelengths relevant for AMO applications. These systems are characterized by criteria: (C1) operation at a design wavelength of choice in the visible (VIS) or near-infrared (IR) spectrum, (C2) a scalable platform that can support large channel counts, (C3) high-intensity modulation extinction and (C4) repeatability compatible with low gate errors, and (C5) fast switching times. Here, we provide a pathway to address these challenges by introducing an atom control architecture based on VIS-IR photonic integrated circuit (PIC) technology. Based on a complementary metal–oxide–semiconductor fabrication process, this atom-control PIC (APIC) technology can meet system requirements (C1)–(C5). As a proof of concept, we demonstrate a 16-channel silicon-nitride-based APIC with (5.8±0.4)ns response times and >30dB extinction ratio at a wavelength of 780 nm.
Normative reference values, determinants and regression equations for the incremental shuttle walk test (ISWT) in healthy Asian population aged 21 to 80 years
Authors: Azman Muhammad Zulhaziq Bin , Huang Katherin S. , Koh Wei Jun , Leong Sarah S. , Ong Benjamin , Soon Johanna L. , Tan Sherman W. , Chan Melissa Y. , Yang Mingxing , Yeung Meredith T. 
Published: September 2023

Background
The validated Incremental Shuttle Walk Test (ISWT) is widely used for evaluating maximal exercise capacity, with the distance-walked (IWSD) as the primary outcome. However, there are no normative reference values (NRV) and reference equations to predict ISWD for the Singaporean population.

Objectives
This study aims to establish the NRV and reference equations for ISWD in healthy Singaporeans aged 21 to 80 and investigate the determining variables during ISWT.

Methods
This cross-sectional study recruited community-dwelling healthy subjects aged 21–80 from the community via convenience sampling. Each subject completed two trials of the ISWT according to the standard protocol. Variables measured during the trials included ISWD, pre-and post-test heart rate (HR), oxygen saturation, blood pressure (BP), modified Borg’s dyspnoea score and Borg’s rate of perceived exertion (RPE).

Results
199 healthy Singaporean (females = 114, males = 85) participated in the study. The overall median ISWD was 660.0 metres (m) [interquartile range (IQR):440.0–850.0]. The age-stratified mean ISWD ranged from 430.0 m (IQR:350.0–450.0) (aged 60–80) to 480.0 m (IQR:438.0–650.0) (aged 40–59) to 780.0 m (IQR:670.0–960.0) (aged 21–39). Gender, age, weight, height and HR change (highest post-test HR minus pre-test HR) were the most significant variables (p < 0.001). IWSD (m) = 651.4(Height, m) +89.7(Gender, male = 1; female = 0) –6.31(Age, years) –3.61(Weight, kilograms) +2.54(HR change, beats per minute); R2 = 0.741. Previously published ISWT reference equations cannot accurately predict the ISWD in the Singaporean population.

Conclusions
This study investigated the ISWD NRV and established reference equations for healthy Singaporeans aged 21–80. The information would be beneficial in setting performance benchmarks to guide physical assessment, intervention and rehabilitation.
Lactate thresholds and role of nitric oxide in male rats performing a test with forced swimming to exhaustion
Authors: Potolitsyna Natalya , Parshukova Olga , Vakhnina Nadezhda , Alisultanova Nadezhda , Kalikova Lubov , Tretyakova Anastasia , Chernykh Alexey , Shadrina Vera , Duryagina Arina , Bojko Evgeny 
Published: September 2023

AbstractThe present study assessed a complex of biochemical parameters at the anaerobic threshold (AT) in untrained male Wistar rats with different times to exhaustion (Tex) from swimming. The first group of rats was randomly divided into six subgroups and subjected to a swimming test to exhaustion without a load or with a load of 2%–10% of body weight (BW). In the first group, we established that for untrained rats, the load of 4% BW in the swimming to exhaustion test was optimal for endurance assessment in comparison with other loads. The second group of rats went through a preliminary test with swimming to exhaustion at 4% BW and was then divided into two subgroups: long swimming time (LST, Tex > 240 min) and short swimming time (SST, Tex < 90 min). All rats of the second group performed, for 6 days, an experimental training protocol: swimming for 20 min each day with weight increasing each day. We established that the AT was 3% BW in SST rats and 5% BW in LST rats. The AT shifted to the right on the lactate curve in LST rats. Also, at the AT in the LST rats, we found significantly lower levels of blood lactate, cortisol, and NO.
GOTHA.digital – Portal für übergreifende Sammlungsforschung
Authors: Carius Hendrikje , Rückert Susanne 
Published: September 2023

Zusammenfassung
Seit April 2023 steht am Sammlungs- und Forschungsstandort Gotha die Plattform GOTHA.digital zur Verfügung. Das integrierte digitale Portal bietet einen Such-, Präsentations- und Forschungsraum für die Gothaer Sammlungen. Es vereint Daten, Objekte und Sammlungen in digitaler Form und erleichtert damit die umfassende Erforschung des historischen Zusammenhangsmaterials, das heute in verschiedenen Institutionen bewahrt wird. In diesem Beitrag wird das Projekt zum Aufbau des Portals sowie seine Komponenten, technischen Grundlagen und zukünftige Perspektiven vorgestellt.
Der Umgang mit potentiell arsenbelasteten Bibliotheksbeständen an der Universitätsbibliothek Kiel – ein Werkstattbericht
Authors: Bruns Jessica , Helmkamp Kerstin , Sindt Ruth 
Published: September 2023

Zusammenfassung
Während die Problematik schadstoffbelasteter Kulturgüter im musealen Bereich bereits seit Längerem bekannt ist, setzt sich erst seit Kurzem die Erkenntnis im Bibliothekswesen durch, dass auch Bibliotheksbestände betroffen sein können. Eine besondere Gefährdung geht dabei von Arsenverbindungen aus, die bis ins 19. Jahrhundert zum Färben von Buchbestandteilen genutzt worden sind. Als eine der ersten Bibliotheken in Deutschland führt die Universitätsbibliothek Kiel derzeit ein großangelegtes Projekt zur Identifikation und Testung potentiell arsenhaltiger Bestände durch. Der vorliegende Beitrag liefert hierzu einen ersten Arbeitsbericht.
In-plane nonlinear postbuckling and buckling analysis of Lee’s frame using absolute nodal coordinate formulation
Authors: Shaukat Abdur Rahman , Lan Peng , Wang Jia , Wang Tengfei , Lu Nianli 
Published: September 2023

Abstract
In this study, four absolute nodal coordinate formulation (ANCF)-based approaches are utilized in order to predict the buckling load of Lee’s frame under concentrated load. The first approach employs the standard two-dimensional shear deformable ANCF beam element based on the general continuum mechanics (GCM). The second approach adopts the standard ANCF beam element modified by the locking alleviation technique known as the strain-split method. The third approach has the standard ANCF beam element with strain energy modified by the enhanced continuum mechanics formulation. The fourth approach utilizes the higher-order ANCF beam element based on the GCM. Two buckling load estimation methods are used, i.e., by tracing the nonlinear equilibrium path of the load–displacement space using the arc-length method and applying the energy criterion, which requires tracking eigenvalues through the dichotomy scheme. Lee’s frame with different boundary conditions including pinned–pinned, fixed-pinned, pinned-fixed, and fixed–fixed are studied. The complex nonlinear responses in the form of snap-through, snap-back, and looping phenomena during nonlinear postbuckling analysis are simulated. The critical buckling loads and buckling mode shapes obtained through the energy criterion-based buckling method are obtained. After the comparison, higher-order beam element is found to be more accurate, stable, and consistent among the studied approaches.
The Yamabe flow on asymptotically flat manifolds
Authors: Chen Eric , Wang Yi 
Published: September 2023

Abstract
We study the Yamabe flow starting from an asymptotically flat manifold

(

M
n

,

g
0

)

(M^{n},g_{0})

.
We show that the flow converges to an asymptotically flat, scalar flat metric in a weighted global sense if

Y
⁢

(
M
,

[

g
0

]

)

>
0

Y(M,[g_{0}])>0

, and show that the flow does not converge otherwise.
If the scalar curvature is nonnegative and integrable, then the ADM mass at time infinity drops by the limit of the total scalar curvature along the flow.
An Early Etruscan Toddler’s Grave in the Transitional Trench Tomb Cemetery of San Simone, San Giuliano (VT): Wealth, Status, and the Hopes of a Family
Authors: Zori Davide , Zori Colleen , Ikeshoji-Orlati Veronica , Aprile Jamie , Baker Lori , Fulton James , Gibbs Anna , Cassotta Angela 
Published: September 2023

Abstract
In this article, we report on a noteworthy early Etruscan trench tomb of a young child, most likely a girl, found intact within the cemetery of San Simone at the San Giuliano necropolis (Viterbo Province). The richly appointed grave contained the remains of a toddler aged 2–3 years, inhumed with wealth befitting an elite adult woman. Typically, the tombs of infants and young children are thought to portray status ascribed to their kin group. The objects interred in the grave reflect the high status of her kinship group, as well as her family’s aspirations for her and the social roles she was meant to have occupied if she had lived longer. Objects in the grave connect her to her ancestors and reveal her anticipated role in textile production and in facilitating and/or orchestrating politically important banquets, possibly even accompanied by sacrificial feasts. But this girl buried at San Giuliano may have been different in other ways as well. She likely looked different, probably having a cleft palate that may have led to her premature death. Some of the objects buried with her, particularly the amber pendant necklace, may have been meant to have curative or healing properties. Using an analysis of the construction of the grave, the osteological remains, and particularly the elaborate funerary assemblage, we explore this child’s expected roles in early Etruscan society and show how her family represented their connections to a broad range of communities across central Italy and beyond.
Analyzing SQL payloads using logistic regression in a big data environment
Authors: Shareef Omar Salah F. , Hasan Rehab Flaih , Farhan Ammar Hatem 
Published: September 2023

Abstract
Protecting big data from attacks on large organizations is essential because of how vital such data are to organizations and individuals. Moreover, such data can be put at risk when attackers gain unauthorized access to information and use it in illegal ways. One of the most common such attacks is the structured query language injection attack (SQLIA). This attack is a vulnerability attack that allows attackers to illegally access a database quickly and easily by manipulating structured query language (SQL) queries, especially when dealing with a big data environment. To address these risks, this study aims to build an approach that acts as a middle protection layer between the client and database server layers and reduces the time consumed to classify the SQL payload sent from the user layer. The proposed method involves training a model by using a machine learning (ML) technique for logistic regression with the Spark ML library that handles big data. An experiment was conducted using the SQLI dataset. Results show that the proposed approach achieved an accuracy of 99.04, a precision of 98.87, a recall of 99.89, and an F-score of 99.04. The time taken to identify and prevent SQLIA is 0.05 s. Our approach can protect the data by using the middle layer. Moreover, using the Spark ML library with ML algorithms gives better accuracy and shortens the time required to determine the type of request sent from the user layer.
The crystal structure of catena-poly[(4-iodopyridine-2,6-dicarboxylato-κ4
O,N,O′,O′′)(4-imidazol-1-yl-pyridine-κN)copper(II)], C15H9N4O4ICu
Authors: Kong Yang , Dang YiXuan , Tian Bin , Wang Chang-Zhao , Han ZiHao , Lu ChenFei 
Published: September 2023

Abstract
C15H9N4O4ICu, monoclinic, P21/c (no. 14), a = 13.6216(4) Å, b = 13.4754(4) Å, c = 8.5023(3) Å, β = 102.610(3)°, V = 1522.99(9) Å3, Z = 4, R
gt(F) = 0.0297, wR
ref(F
2) = 0.0781, T = 293 K.