bluuebunny/crossref_metadata_2025_split huggingface dataset:
Geochronology, Petrogenesis and Tectonic Setting of the Late Jurassic I‐type Granites in the North Qinling Orogenic Belt, Central China
Authors: HUANG Yanna , LI Dunpeng , XIAO Aifang , XU Songming 
Published: May 2023

AbstractThe North Qinling Orogenic Belt (NQOB) is a composite orogenic belt in central China. It started evolving during the Meso–Neoproterozoic period and underwent multiple stages of plate subduction and collision before entering intra‐continental orogeny in the Late Triassic. The Meso–Cenozoic intra‐continental orogeny and tectonic evolution had different responses in various terranes of the belt, with the tectonic evolution of the middle part of the belt being particularly controversial. The granites distributed in the Dayu and Kuyu areas in the middle part of the NQOB can provide an important window for revealing the geodynamic mechanisms of the NQOB. The main lithology of Dayu and Kuyu granites is biotite monzogranite, and the zircon U‐Pb dating yielded intrusive ages of 151.3 ± 3.4 Ma and 147.7 ± 1.5 Ma, respectively. The dates suggest that the biotite monzogranite were formed at the end of the Late Jurassic. The whole‐rock geochemistry analysis shows that the granites in the study areas are characterized by slightly high SiO2 (64.50–68.88 wt%) and high Al2O3 (15.12–16.24 wt%) and Na2O (3.55–3.80 wt%) contents. They are also enriched in light rare earth elements, large ion lithophile elements (e.g., Ba, K, La, Pb and Sr), and depleted in high field strength elements (HFSEs) (e.g., Ta, Nb, P and Ti). Additionally, the granites have weakly negative–slightly positive Eu anomalies (δEu = 0.91–1.19). Zircon Lu‐Hf isotopic analysis showed εHf(t) = –6.1—‐3.8, and the two‐stage model age is T2DM(crust) = 1.5–1.6 Ga. The granites in the study areas are analyzed as weak peraluminous high‐K calc‐alkaline I‐type granites. They formed by partial melting of the thickened ancient lower crust, accompanied by the addition of minor mantle‐derived materials. During magma ascent, they experienced fractional crystallization, with residual garnet and amphibole for a certain proportion in the magma source region. Comprehensive the geotectonic data suggest that the end of the Late Jurassic granite magmatism in the Dayu and Kuyu areas represents a compression–extension transition regime. It may have been a response to multiple tectonic mechanisms, such as the late Mesozoic intra‐continental southward subduction of the North China Craton and the remote effect of the Paleo‐Pacific Plate subduction.
Detrital Zircon Geochronology and Provenance of Metasedimentary Rocks from the Susong Complex Zone in the Dabie Orogen
Authors: WU Zheng , YANG Yang , LIU Yican , ZHANG Chengwei 
Published: May 2023

AbstractThe Susong complex zone is a relatively low‐grade metamorphic unit located in the southern part of the Dabie orogen and preserves a variety of metasedimentary rocks, mostly with epidote–amphibolite facies. However, their depositional age, provenance and tectonic setting of sedimentary protolith remain controversial due to the lack of fossils, precise dating and integrated geochemical investigation. This study has conducted whole‐rock elemental, and zircon U‐Pb SHRIMP dating and Lu‐Hf isotope analyses on three types of representative metasedimentary rocks including garnet‐bearing mica‐quartz schist, graphite‐muscovite‐quartz schist and dolomitic marble from the Susong complex zone. The U‐Pb SHRIMP dating data indicate that the sedimentary protolith of these rocks have the maximum depositional ages of less than 840–750 Ma and have various sedimentary provenances. In combination with zircon Lu‐Hf isotope compositions, the provenance of the metasedimentary rocks in the region is for the first time documented to be mainly derived from four groups of magmatic rocks formed at ∼2.5 Ga, ∼2.0 Ga, ∼1.4 Ga and ∼0.8 Ga in response to four episodes of igneous activity in the northeastern margin of the Yangtze Block. The conventional geothermobarometry combined with rare metamorphic zircon ages indicate that the studied rocks underwent the Late Triassic continental subduction‐related metamorphism with peak epidote–amphibolite facies conditions at P = 0.34–0.91 GPa and T = 427–532°C. In addition, results of the elemental contents (i.e., La, Ce, Th and ΣREE) and ratios (i.e., Eu/Eu* and LaN/YbN) suggest that the protoliths of the metasedimentary rocks were mainly shales, wackes and limestones, most probably related to the Rodinia supercontinent rifting along the northern margin of the Yangtze Block during the Neoproterozoic.
Environmental Effects on Differential Organic Matter Enrichment of the Lower Cambrian Shale, Tarim Basin, NW China
Authors: ZHAO Yawen , WU Guanghui , YI Yan , CHEN Yongquan , WU Yonghong , JING Bing , WANG Jian 
Published: May 2023

AbstractEarly Cambrian shale is an important petroleum source rock around the world. Because of little drilling data and poor seismic data, until recently, organic matter enrichment of the Lower Cambrian Yuertusi and Xishanbulake formations shale is still an enigma in the Tarim Basin, northwestern China. Total organic carbon (TOC), major and trace element data of Cambrian shale samples from five boreholes have been analyzed to decipher the mechanism of the organic matter enrichment. The results show that the shales deposited in the western restricted intraplatform have much higher TOC contents (3.2%–19.8%, on average 11.0%) than those from the eastern basin (2.2%–10.2%, on average 4.5%). The paleoproductivity proxies (Ba, Ba/Al, P/Al) in the western restricted platform are much higher than those in the eastern basin. The trace element indicators such as V/Cr, Ni/Co, Mo–TOC and MoEF–UEF suggest an anoxic environment across the basin, but a more restricted environment in the western intraplatform. The paleoproductivity rather than anoxic condition and hydrothermal activity are concluded to have resulted in the differentiation of the organic matter enrichment from the western intraplatform to eastern basin in the early Cambrian shales; the restricted environment was favorable for paleoproductivity and preservation of organic matter.
Efficacy of certolizumab pegol across baseline rheumatoid factor subgroups in patients with rheumatoid arthritis: Post‐hoc analysis of clinical trials
Authors: Tanaka Yoshiya , Takeuchi Tsutomu , Haaland Derek , Hall Stephen , Inanc Nevsun , Li Zhanguo , Xavier Ricardo M. , Cara Carlos , Tilt Nicola , Taylor Peter C. 
Published: May 2023

AbstractAimCertolizumab pegol (CZP), an Fc‐free, PEGylated tumor necrosis factor inhibitor (TNFi), has shown rapid and sustained reduction in signs and symptoms of rheumatoid arthritis (RA). Elevated rheumatoid factor (RF) level has been associated with RA disease progression and poorer TNFi response. We assessed the efficacy of CZP in patients with early and established RA across baseline RF levels.MethodsThis post‐hoc analysis included data from 6 trials: C‐OPERA (NCT01451203), pooled RAPID trials (RAPID‐1 [NCT00152386], RAPID‐2 [NCT00160602], J‐RAPID [NCT00791999], RAPID‐C [NCT02151851]), and EXXELERATE (NCT01500278). Patients who received CZP or placebo/comparator with methotrexate (MTX) were categorized by baseline RF quartiles. Efficacy was assessed with Disease Activity Score‐28 erythrocyte sedimentation rate (DAS28‐ESR).ResultsOverall, 316, 1537, and 908 patients were included in C‐OPERA, pooled RAPID trials, and EXXELERATE, respectively. Patient demographics and baseline disease characteristics were similar between treatment groups and across RF quartiles. DAS28‐ESR low disease activity (LDA) and remission (REM) rates were numerically higher in the CZP + MTX group than PBO + MTX group at weeks 12 and 24, across RF quartiles. LDA and REM rates in the CZP + MTX groups were comparable across RF quartiles at weeks 12 and 24. Mean DAS28‐ESR decreased from week 0 to week 24 in the CZP + MTX groups, across RF quartiles.ConclusionCZP showed steady efficacy across baseline RF quartiles in patients with early and established RA, over 24 weeks. CZP treatment may be considered in patients with RA irrespective of baseline RF levels and time from diagnosis.
EvoPhylo: An r package for pre‐ and postprocessing of morphological data from relaxed clock Bayesian phylogenetics
Authors: Simões Tiago R. , Greifer Noah , Barido‐Sottani Joëlle , Pierce Stephanie E. 
Published: May 2023

Abstract

Relaxed clock Bayesian evolutionary inference (BEI) enables the co‐estimation of phylogenetic trees and evolutionary parameters associated with models of character and lineage evolution. Fast advances in new model developments over the past decade have boosted BEI as a major macroevolutionary analytical framework using morphological and/or molecular data across vastly different study systems. However, there is limited availability of bioinformatic tools to pre‐ and postprocess data from BEI, such as identifying morphological data partitions, or statistically testing and creating publication quality plots of evolutionary hypotheses.

Here, we introduce EvoPhylo, an r package to perform automated morphological character partitioning and analyse macroevolutionary parameter from relaxed clock (time‐calibrated) BEI outputted by the programs Mr.Bayes and BEAST2. These include rates of evolution and mode of selection for each character partition, diversification rate parameters, and handling fossil‐only posterior trees.

We present the theoretical background behind EvoPhylo's functions and analytical tools for evolutionary hypothesis testing, its potential uses, and interpretation of its results with a series of vignettes and links to a step‐by‐step tutorial using examples from two empirical datasets.

EvoPhylo will facilitate the use of Bayesian relaxed clocks as a tool for macroevolutionary inference across a wide range of users and fields of research, especially those that make usage of morphological datasets, from paleontological to total evidence dating analyses.
Whole genome sequencing identifies candidate genes and mutations that can explain diluted and other colour varieties of domestic canaries (Serinus canaria)
Authors: Bovo Samuele , Ribani Anisa , Utzeri Valerio Joe , Taurisano Valeria , Bertarini Gianmaria , Fontanesi Luca 
Published: May 2023

AbstractThe domestic canary (Serinus canaria) is one of the most common pet birds and has been extensively selected and bred over the last few centuries to constitute many different varieties. Plumage pigmentation is one of the main phenotypic traits that distinguish canary breeds and lines. Feather colours in these birds, similarly to other avian species, are mainly depended on the presence of two major types of pigments: carotenoids and melanins. In this study, we exploited whole genome sequencing (WGS) datasets produced from five canary lines or populations (Black Frosted Yellow, Opal, Onyx, Opal × Onyx and Mogno, some of which carrying different putative dilute alleles), complemented with other WGS datasets retrieved from previous studies, to identify candidate genes that might explain pigmentation variability across canary breeds and varieties. Sequencing data were obtained using a DNA pool‐seq approach and genomic data were compared using window‐based FST analyses. We identified signatures of selection in genomic regions harbouring genes involved in carotenoid‐derived pigmentation variants (CYP2J19, EDC, BCO2 and SCARB1), confirming the results reported by previous works, and identified several other signatures of selection in the correspondence of melanogenesis‐related genes (AGRP, ASIP, DCT, EDNRB, KITLG, MITF, MLPH, SLC45A2, TYRP1 and ZEB2). Two putative causative mutations were identified in the MLPH gene that may explain the Opal and Onyx dilute mutant alleles. Other signatures of selection were also identified that might explain additional phenotypic differences between the investigated canary populations.
Enhancing economic freedom via school choice and competition: Have state laws been enabling enough to generate broad‐based effects?
Authors: Garen John 
Published: May 2023

AbstractAn aspect of economic freedom that varies across U.S. states is K‐12 educational freedom. Some states allow a degree of choice for families in selecting schools outside public schools for their children. However, the enabling laws for such programs are often quite restrictive and limited to few children. Can this limited degree of competition and choice have a noticeable effect on an entire state's overall K‐12 performance? I find strikingly large test score gains for states that have adopted voucher programs and/or Education Savings Accounts (ESAs), swamping the effect of per pupil K‐12 spending on test scores. Moreover, vouchers and ESAs are associated with less per pupil spending. These effects are robust to a host of specification checks. A key factor is the amount of a program's funding that “follows the student,” even if a small number of students are eligible. Overall, it seems that even a small measure of educational freedom has a large effect.
Dose–response of virtual reality training of paediatric emergencies in a randomised simulation‐based setting
Authors: Lietz Andrea , Kraller Julian , Hoffelner Alexander , Ritschl Valentin , Berger Angelika , Wagner Michael 
Published: May 2023

AbstractAimTo determine the effect of different virtual reality training intervals on individual performance to facilitate the optimal implementation of medical virtual reality training.MethodsEmergency scenarios in virtual reality were performed by 36 medical students from the Medical University of Vienna. After baseline training, the participants were randomised into three groups of equal size and underwent virtual reality training at different time intervals (monthly, one training after 3 months, and no further training) before undergoing final assessment training after 6 months.ResultsGroup A, with monthly training exercises, improved their performance score significantly by 1.75 mean score points compared with Group B, who repeated baseline training after 3 months. Statistically significant difference was indicated when comparing Group A with Group C, which was not further trained and served as the control group.ConclusionOne‐month intervals are associated with statistically significant performance improvements compared with additional training after 3 months and to a control group without regular training. The results show that training intervals of 3 months or longer are insufficient to achieve high performance scores. Virtual reality training is a cost‐effective alternative to conventional simulation‐based training for regular practice.
Moral expertise revisited
Authors: Gordon John‐Stewart 
Published: May 2023

AbstractIn recent years, there has been a lively (bio‐)ethical debate on the nature of moral expertise and the concept of moral experts. However, there is currently no common ground concerning most issues. Against this background, this paper has two main goals. First, in more general terms, it examines some of the problems concerning moral expertise and experts, with a special focus on moral advice and testimony. Second, it applies the results in the context of medical ethics, especially in the clinical setting. By situating the debate in the clinical setting, one arrives at some important conclusions to better understand the relevant concepts and vital problems in the general discussion on moral expertise and the requirements of who counts as a moral expert.
Adolescent difficulties during parental deployment and anxiety: A focus on measurement and family processes
Authors: Sherman Haley , O'Neal Catherine Walker , Tidwell Allison , Lucier‐Greer Mallory 
Published: May 2023

AbstractApproximately 60% of deployed service members leave behind immediate family members, and although military families tend to be adaptive and resilient, evidence suggests that deployments are challenging and difficulties can arise during transitions and family separation, especially for adolescents. Grounded in the family attachment network model and the ABC‐X model of family stress, the current study utilized a sample of 204 military families with an active‐duty father, civilian mother and adolescent and examined parents' perceptions of adolescents' difficulties during deployment in relation to all three family members' perceptions of the adolescents' mental health (i.e., anxiety symptoms) following deployment. First, analyses of measurement invariance indicated that service members and civilian parents were generally reporting on the same underlying construct of their adolescents' difficulties during parental deployment. Next, a structural equation model demonstrated considerable overlap in service member and civilian parent reports of their adolescents' difficulties during a parental deployment (r = 0.47). Finally, both parents' perceptions of adolescent difficulties during parental deployment were related to their own perceptions of the adolescent's current anxiety but not to the adolescents' reports of their own anxiety symptoms or to the other parent's report of the adolescents' anxiety symptoms. Findings provide support for utilizing these theories in combination, such that disruptions to the family system, and the attachment relationships within that system, in one stage of the deployment cycle, may imply that there are implications for individual‐level functioning, namely, anxiety, in the next stage of the deployment cycle. Findings also underscore the importance of examining our measurement tools and collecting data from multiple family members to understand family processes.
“An A is an A?” Maybe in North America, but less so elsewhere
Authors: Hiebl Martin R. W. 
Published: May 2023

AbstractWith reference to recent debate about the increasing “an A is an A” mentality at business schools, I provide evidence on the prevalence of this mentality in North America versus other regions of the world (RoW). The evidence presented is derived from the data selection procedures employed in conducting systematic reviews of management research because a focus on specific journals in this selection can be seen as an artifact of the “an A is an A” mentality. My findings suggest that this mindset is more widespread in North American business schools and less so elsewhere. This implies that in order to find remedies against the detrimental effects of the “an A is an A” mentality, North American business school leaders and academics might find inspiration in other countries. In addition, I suggest that a part of the solution could also be directing PhD students toward a more inclusive selection of journals and articles in reviews of management research.
Transcriptomic responses of peripheral blood mononuclear cells to cyclosporin and etanercept in a female infant with juvenile generalized pustular psoriasis
Authors: Lin Yu‐Chen , Jeng Yu‐Chen , Aala Wilson Jr F. , Hong Yi‐Kai , Chen Pin‐Hsuan , Chuang Ya‐Ru , Yang Chao‐Chun , Hsu Chao‐Kai 
Published: May 2023

AbstractGeneralized pustular psoriasis (GPP) is a rare but severe form of psoriasis. An early onset of the diseases is correlated with mutations among IL36RN, CARD14, AP1S3, MPO and SERPINA3 genes. Systemic biological agents including anti‐TNF‐α, anti‐IL‐17, anti‐IL‐12/IL‐23, anti‐IL1R, anti‐IL1β and anti‐IL‐36R act as novel treatment methods for GPP. Herein we report a female infant clinically diagnosed with GPP since she was 10‐month‐old. Results of whole‐exome sequencing (WES) and Sanger sequencing revealed a reported heterozygous IL36RN (c.115+6T>C) and another reported heterozygous SERPINA3 frame‐shifting variant (c.1247_1248del). Initial cyclosporin treatment for the patient led to a partial remission of the symptoms. However, the patient reached nearly total remission of pustules and erythema after anti‐TNF‐α inhibitor etanercept treatment. Results of further RNA sequencing (RNA‐seq) done on peripheral blood mononuclear cells correlated with the clinical responses, showing that cyclosporin suppressed a portion of the neutrophil‐related genes, while most genes associated with neutrophil activation, neutrophil‐mediated immunity and degranulation were downregulated by the subsequent etanercept treatment. We report this case to demonstrate WES and RNA‐seq in combination could come in handy in reaching a precise diagnosis and in evaluating or even predicting the molecular alterations underlying clinical treatment effectiveness.
Imputing missing data in plant traits: A guide to improve gap‐filling
Authors: Joswig Julia S. , Kattge Jens , Kraemer Guido , Mahecha Miguel D. , Rüger Nadja , Schaepman Michael E. , Schrodt Franziska , Schuman Meredith C. 
Published: May 2023

AbstractAimGlobally distributed plant trait data are increasingly used to understand relationships between biodiversity and ecosystem processes. However, global trait databases are sparse because they are compiled from many, mostly small databases. This sparsity in both trait space completeness and geographical distribution limits the potential for both multivariate and global analyses. Thus, ‘gap‐filling’ approaches are often used to impute missing trait data. Recent methods, like Bayesian hierarchical probabilistic matrix factorization (BHPMF), can impute large and sparse data sets using side information. We investigate whether BHPMF imputation leads to biases in trait space and identify aspects influencing bias to provide guidance for its usage.InnovationWe use a fully observed trait data set from which entries are randomly removed, along with extensive but sparse additional data. We use BHPMF for imputation and evaluate bias by: (1) accuracy (residuals, RMSE, trait means), (2) correlations (bi‐ and multivariate) and (3) taxonomic and functional clustering (valuewise, uni‐ and multivariate). BHPMF preserves general patterns of trait distributions but induces taxonomic clustering. Data set–external trait data had little effect on induced taxonomic clustering and stabilized trait–trait correlations.Main ConclusionsOur study extends the criteria for the evaluation of gap‐filling beyond RMSE, providing insight into statistical data structure and allowing better informed use of imputed trait data, with improved practice for imputation. We expect our findings to be valuable beyond applications in plant ecology, for any study using hierarchical side information for imputation.