bluuebunny/crossref_metadata_2025_split huggingface dataset:
Three-dimensional Orbit of AC Her Determined: Binary-induced Truncation Cannot Explain the Large Cavity in This Post-AGB Transition Disk
Authors: Anugu Narsireddy , Kluska Jacques , Gardner Tyler , Monnier John D. , Van Winckel Hans , Schaefer Gail H. , Kraus Stefan , Le Bouquin Jean-Baptiste , Ertel Steve , Mérand Antoine , Klement Robert , Davies Claire L , Ennis Jacob , Labdon Aaron , Lanthermann Cyprien , Setterholm Benjamin R. , Brummelaar Theo ten , Corporaal Akke , Sabin Laurence , Rajagopal Jayadev 
Published: June 2023

Abstract
Some evolved binaries, namely post–asymptotic giant branch (AGB) binaries, are surrounded by stable and massive circumbinary disks similar to protoplanetary disks found around young stars. Around 10% of these disks are transition disks: they have a large inner cavity in the dust. Previous interferometric measurements and modeling have ruled out these cavities being formed by dust sublimation and suggested that they are due to massive circumbinary planets that trap dust in the disk and produce the observed depletion of refractory elements on the surfaces of the post-AGB stars. In this study, we test an alternative scenario in which the large cavities could be due to dynamical truncation from the inner binary. We performed near-infrared interferometric observations with the CHARA Array on the archetype of such a transition disk around a post-AGB binary: AC Her. We detect the companion at ten epochs over 4 yr and determine the three-dimensional orbit using these astrometric measurements in combination with a radial velocity time series. This is the first astrometric orbit constructed for a post-AGB binary system. We derive the best-fit orbit with a semimajor axis of 2.01 ± 0.01 mas (2.83 ± 0.08 au), inclination (142.9 ± 1.1)°, and longitude of the ascending node (155.1 ± 1.8)°. We find that the theoretical dynamical truncation and dust sublimation radii are at least ∼3× smaller than the observed inner disk radius (∼21.5 mas or 30 au). This strengthens the hypothesis that the origin of the cavity is due to the presence of a circumbinary planet.
Gliese 581c: Habitability Unlikely—but not Hopeless Either
Authors: Cuntz Manfred 
Published: June 2023

Abstract
There is continued interest in the study of habitability for the Gliese 581 system. Previously, for Gliese 581c, a quasi-consensus has been reached that this planet, a super-Earth, is interior to the stellar habitable zone, akin to Venus in the solar system. In this work, I revisit this view considering detailed results about the orbital planetary parameters (including their uncertainties) and previous studies on habitability.
A dual perspective of organizational resilience (OR) and information technology systems resilience (ITSR): an analysis of interdependencies and tensions
Authors: Gardner LeGars Joanne , Simonin Jacques , Waldeck Roger , Puentes John 
Published: June 2023

Contemporary organizations face a rising incidence of disasters, extreme events and crises (Boin and Lodge 2021). In parallel, the socioeconomic landscape is increasingly complex which intensifies inter-organizational dependencies and the risk of cascading failures (Ansell et al. 2021). To survive and perhaps thrive, organizations must cultivate organizational resilience (OR). However, their capacity to do so is currently curtailed. Although it is widely recognized that the performance of organizational processes, functions and capabilities is closely aligned to the effectiveness of associated information technology systems (ITS) (Schultze and Orlikowski 2004); models of OR have yet to elucidate mechanisms by which ITS contribute to resilience capabilities (Annarelli and Nonino 2016). In this conceptual paper, which is a work in progress, we reflect upon the nature of interdependencies and tensions between ITS resilience (ITSR) and OR. We adopt a deductive, qualitative approach to systematically compare OR & ITSR. Our comparative analysis is informed by OR models described by Duchek (2020), Sheffi and Rice Jr (2005) and Weick and Sutcliffe (2011), while for ITSR, we employ the Reactive Manifesto as interpreted by Bonér et al. (2014) and Debski et al. (2017).
Figs 1, 2 illustrate our interpretation of each resilience construct.
As may be seen on Fig. 1 we interpret OR as a three-phase process including preemptive, proactive & recovery phases each possessing associated resilience capabilities. The process may occasion three operational outcomes (or levels of resilience maturity). 1st , 2nd and 3rd order resilience denote organizations that when a disruption occurs,

merely maintain key operations,

rapidly achieve a return to normal operations or

that capitalize on a disruption to achieve an improved post-shock trajectory respectively.

merely maintain key operations,
rapidly achieve a return to normal operations or
that capitalize on a disruption to achieve an improved post-shock trajectory respectively.
ITSR is interpreted via the notion, reactive scalability which describes an organizational system that is both responsive and scalable (Debski et al. 2017) i.e., which is able to rapidly achieve (responsive) appropriately dimensioned (scalable) adaptations to intra and extra-organizational changes.
Our analysis employs a multi-level approach. The preliminary results of the analysis are presented in Table 1.
Upon completion of the analysis, we will elaborate theoretical propositions pertaining to the relationship between the OR and ITSR constructs to guide subsequent empirical research to bridge the theoretical divide between these in reality, indissociable resilience constructs. This comprises the main anticipated contribution.
Muscles et géopolitique. Fragilité et résilience des corps et des grandes puissances dans James Bond et Mission impossible
Authors: Borzakian Manouk , Rouiaï Nashidil 
Published: June 2023

Dans les années 1980, les « corps durs » du cinéma nord-américain, théorisés par Susan Jeffords, ont accompagné la politique reaganienne, incarnant une nation nord-américaine sûre d’elle et belliciste. Au lendemain des attaques du 11 septembre, deux franchises de cinéma d’aventure, James Bond et Mission impossible , reprennent le flambeau. Dans un monde présenté comme instable, menaçant et violent, des corps masculins musclés et puissants réalisent les cascades les plus ahurissantes et survivent aux pires agressions pour mener à bien leur mission. En cela, ils témoignent du retour d’une masculinité dominante tout en muscles et en puissance. Ce faisant, ils agissent comme des synecdoques corporelles : ces corps incarnent la perception d’elles-mêmes et de leur territoire de deux nations désireuses d’affirmer leur place au sein de l’ordre géopolitique mondial et de se convaincre de leur propre puissance et de leur caractère éternel.
Le fonds citoyen franco-allemand : le nouvel instrument de la coopération franco-allemande ?
Authors: Kurc Benjamin 
Published: June 2023

Le Fonds citoyen franco-allemand est un nouvel outil issu du traité d’Aix-la-Chapelle, signé le 22 janvier 2019. Sa création s’inscrit dans la continuité du renforcement de la coopération franco-allemande amorcée par le traité de l’Élysée, signé en 1963. Ce dernier avait notamment permis la naissance de l’Office franco-allemande pour la Jeunesse, qui s’est imposé au fil des ans comme un acteur incontournable des relations franco-allemandes. Le traité d’Aix-la-Chapelle quant à lui a pour ambition de redynamiser la relation franco-allemande en approfondissant les champs d’action de celle-ci. Le Fonds citoyen franco-allemand est un des projets phares de ce traité. Il a pour but de raccrocher les deux peuples en soutenant des projets issus de la société civile. Le lancement du Fonds citoyen a été opéré le 16 avril 2020 en pleine pandémie. Le dispositif rencontre depuis le début un énorme succès. En deux ans son budget est passé de 2,4 à 5 millions € et il a pu soutenir en 3 ans plus de 1 500 projets. Sa flexibilité et son accessibilité en fait un outil sollicité par les acteurs et les actrices de la société civile ainsi que par les communes. Néanmoins, son succès croissant le place devant de nouveaux enjeux qui sont tout autant de promesses pour l’avenir.
De l’apprentissage de la langue du partenaire à la défense du plurilinguisme européen : quelles réalités et quelles ambitions pour le franco-allemand ?
Authors: Barrière Anne-Lise , Serrier Barbara , Volkwein Alice 
Published: June 2023

La nouvelle feuille de route commune intitulée Stratégies pour le développement et l’apprentissage de la langue du partenaire publiée à l’occasion des 60 ans du Traité de l’Élysée traduit une inquiétude et une volonté de relance face à des effectifs d’apprenants en chute nette depuis plusieurs années – et ce malgré un soutien institutionnel et une action politique forte dont l’OFAJ est le principal acteur. Les autrices de cette contribution, enseignantes à Paris et à Berlin, proposent un état des lieux au plus près des réalités scolaires de ces deux régions-capitales à la fois comparables en termes de taille et de diversité de population mais bien différentes quant à l’organisation et au pilotage de l’offre scolaire. L’approche croisée met en lumière et analyse les problématiques communes (raisons de la baisse des effectifs, situation des enseignants, soutien institutionnel) mais aussi les succès et échecs propres à chaque système scolaire. L’enseignement de la langue du partenaire est-il condamné à ne s’épanouir, en région parisienne comme à Berlin, que dans des filières spécifiques d’excellence destinées, ne serait-ce que par leur implantation géographique, à un public plutôt favorisé ? L’Europe ne peut se passer d’une politique ambitieuse d’éducation plurilingue. Les autrices explorent les pistes qu’offre l’expertise du franco-allemand pour la relancer.
Les premiers pas du RER métropolitain transfrontalier de Strasbourg : enseignements des expériences allemandes et suisses pour un renouveau de services ferroviaires métropolitains en France
Authors: Rousseau Marie-Léa , Guihéry Laurent 
Published: June 2023

Les enjeux liés aux mobilités dans les aires métropolitaines concernent fondamentalement le report modal de la voiture individuelle vers le transport public, et plus particulièrement le transport ferroviaire. L’objectif est de réduire l’empreinte carbone mais aussi de réduire la congestion dans les accès au centre-ville. Il importe également de réduire le coût de la mobilité individuelle, qui n’a cessé de croître ces dernières années (prix de l’essence). Dans cette perspective, les RER métropolitains ont acquis une solide réputation d’alternative modale, en particulier dans les pays germaniques. Fin 2022, Strasbourg a mis en service un réseau de RER, avec des ramifications transfrontalières vers l’Allemagne, réseau qui connaît des débuts difficiles. Quels sont les enseignements des expériences allemandes mais également suisse - pour le développement des RER métropolitain en France ?
NUDT5 promotes the growth, metastasis, and Warburg effect of IDH wild-type glioblastoma multiforme cells by upregulating TRIM47
Authors: Zhang Zi-Fa , Liu Shu-Ming 
Published: June 2023

Objective:
To explore the regulatory mechanism of NUDT5 in glioblastoma multiforme (GBM).

Methods:
GEPIA database was used to predict the expressions of NUDT5 and tripartite motif family proteins 47 (TRIM47) in GBM patients. RT-qPCR and Western blot analyses were performed to examine NUDT5 expression in GBM cells. LN-229 cell proliferation, migration as well as invasion were estimated by CCK-8, colony formation, wound healing, and Transwell assays following interference with NUDT5. ECAR assay, L-lactic acid kit, glucose detection kit, and ATP detection kit were applied for the detection of glycolysis-related indexes. Co-immunoprecipitation experiment was carried out to verify the relationship between NUDT5 and TRIM47.

Results:
GEPIA database showed that NUDT5 expression was significantly increased in GBM patients. Inhibiting the expression of NUDT5 in GBM cells significantly suppressed the viability, proliferation, invasion, migration, and glycolysis of GBM cells. Moreover, TRIM47 was highly expressed in GBM cells and interacted with NUDT5. Overexpression of TRIM47 partially reversed the inhibitory effect of NUDT5 downregulation on the proliferation, metastasis, and glycolysis of GBM cells.

Conclusions:
NUDT5 promotes the growth, metastasis, and Warburg effect of GBM cells by upregulating TRIM47. Both NUDT5 and TRIM47 can be used as targets for GMB treatment.
Minimally Invasive Direct Coronary Artery Bypass and Percutaneous Coronary Intervention Followed by Transcatheter Aortic Valve Implantation: A Promising Concept in High-risk Octogenarians
Authors: Alozie Anthony , Öner Alper , Löser Benjamin , Dohmen Pascal M. 
Published: June 2023

ABSTRACT

Objectives:
In this article, we present our initial clinical experience with staged minimally invasive direct coronary bypass (MIDCAB), percutaneous coronary intervention (PCI), and transcatheter aortic valve implantation (TAVI) in high-risk octogenarians (Hybrid).

Background:
The use of percutaneous techniques for managing structural heart diseases, especially in elderly high-risk patients, has revolutionized the treatment of structural heart diseases. These procedures are present predominantly being offered as isolated interventions. The feasibility, clinical benefit, and outcomes of combining these techniques with MIDCAB have not been sufficiently explored and have subsequently been underreported in the contemporary literature.

Methods:
Four consecutive octogenarians with severe aortic stenosis (AS) and complex coronary artery disease (CAD) that were at high risk for conventional surgery with extracorporeal circulation (ECC) were discussed in our Multidisciplinary Heart Team (MDH). Our MDH consisted of an interventional cardiologist, cardiac surgeon, and cardiac anesthesiologist. A hybrid approach with the alternative strategy comprising of MIDCAB, PCI, and TAVI in a staged fashion was agreed on. All 4 patients had both PCI/stenting and MIDCAB prior to deployment of the TAVI-prosthesis.

Results:
From January 2019 to December 2020, 4 consecutive patients aged between 83 and 85 (3 male/1 female) years were scheduled for MIDCAB/PCI followed by percutaneous treatment of severe symptomatic AS. Intraoperatively, one patient was converted to full sternotomy, and surgery was performed by off-pump coronary artery bypass grafting. The overall procedural success rate was 100% in all 4 patients with resolution of their initial presenting cardiopulmonary symptoms. There were no severe complications associated with all hybrid procedures. There was no 30-day mortality in all patients. All patients were discharged home with a median hospital stay ranging between 9 and 25 days. All patients have since then been followed-up regularly. There was one noncardiac-related mortality at 6-months postsurgery. All other patients were well at 1-year follow-up with improved New York Heart Association Class II.

Conclusions:
In a selected group of elderly, high prohibitive risk patients with CAD and severe symptomatic AS, a staged approach with MIDCAB and PCI followed by TAVI can be safely performed with excellent outcomes. We advocate a MDH-based preliminary evaluation of this patient cohort in selecting suitable patients and appropriate timing of each stage of the hybrid procedure.
Comparision of Cardiac Output Measured by Transthoracic Echocardiography with Continuous Cardiac Output Measured by Pressure Recording Analytical Method
Authors: Madhuri M. Roja , Singh Naveen G. , Nagaraja P. S , Pranathi E , Shankar C. G Prabhu , Satish N , Prabhakar V , Gupta Apoorva 
Published: June 2023

ABSTRACT

Background:
Low cardiac output is a common complication following cardiac surgery and it is associated with higher mortality in the pediatric population. A gold standard method for cardiac output (CO) monitoring in the pediatric population is lacking. The present study was conducted to validate cardiac output and cardiac index measured by transthoracic echocardiography and Pressure recording analytical method, a continuous pulse contour method, MostCare Up in postoperative pediatric cardiac surgical patients.

Materials and Methods:
This was a prospective observational clinical study conducted at a tertiary care hospital. A total of 23 pediatric patients weighed between 2 and 20 kg who had undergone elective cardiac surgery were included in the study.

Results:
Spearman’s correlation coefficient of CO between transthoracic echocardiography (TTE) and Pressure Recording Analytical Method (PRAM) showed of positive correlation (r = 0.69, 95% Confidence interval 0.59-0.77, P < 0.0001) Linear regression equations for CO between TTE and PRAM were y = 0.55 + 0.88x (R2 = 0.46, P < 0.0001). (y = PRAM, x = TTE), respectively. Bland- Altman plot for CO between TTE and PRAM showed a bias of -0.397 with limits of the agreement being -2.01 to 1.22. Polar plot analysis showed an angular bias of 6.55° with radial limits of the agreement being -21.46 to 34.58 for CO and angular bias of 6.22° with radial limits of the agreement being -22.4 to 34.84 for CI.

Conclusion:
PRAM has shown good trending ability for cardiac output. However, values measured by PRAM are not interchangeable with the values measured by transthoracic echocardiography.
Correlation of Venous to Arterial Carbon Dioxide Partial Pressure Difference with other Cardiac Output Indices in Patients Undergoing Intracardiac Repair for Tetralogy of Fallot
Authors: Singh Guriqbal , Pujara Jigisha , Trivedi Visharad , Uday Dhawalikar Deepti , Masaniya Jyoti , Babu Mittapalli Jeevan , Bhandari Chanchal Daulal 
Published: June 2023

ABSTRACT

Background:
Clearance of tissue carbon dioxide by circulation is measured by venous to arterial carbon dioxide partial pressure difference (AVCO2) and is correlated with cardiac output (CO) in critically ill adult patients. This study aimed to correlate AVCO2 with other CO indices like arteriovenous oxygen saturation difference (AVO2), central venous oxygen saturation (ScVO2), and serum lactate in pediatric patients undergoing intracardiac repair (ICR) for tetralogy of Fallot (TOF).

Methods:
We conducted a prospective observational study in 50 patients, of age 5 months to 5 years, undergoing ICR for TOF and analyzed AVO2, AVCO2, ScVO2, and lactate from arterial and venous blood gas pairs obtained at different time intervals from admission to pediatric intensive care unit (PICU) (T0), at 6 h (T1), 12 h (T2), 24 h (T3), and 48 h (T4) postoperatively. Bivariate correlations were analyzed using Pearson for parametric variables.

Results:
Admission AVCO2 was not correlated with AVO2 (R2 = 0.166, P = 0.246), ScVO2 (R2 = -2.2, P = 0.124), and lactate (R2 = -0.07, P = 0.624). At T1, AVCO2 was correlated with AVO2 (R2 = 0.283, P = 0.0464) but not with ScVO2 (R2 = - 0.25, P = 0.079) and lactate (R2 = -0.07, P = 0.623). At T2, T3 and T4, AVCO2 was correlated with AVO2 (R2 = 0.338,0.440 & 0.318, P = 0.0162, 0.0013, and 0.024), ScVO2 (R2 = - 0.344, - 0.488, and -0.366; P = 0.0143, <0.0001, and 0.017), and lactate (R2 = 0.305, 0.467 and 0.607; P = 0.0314, 0.00062 and <0.0001). AVCO2 was negatively correlated with ScVO2. No correlation observed between admission AVCO2 and mechanical ventilation duration. Two nonsurvivors had higher value of admission AVCO2 compared to survivors.

Conclusion:
AVCO2 is correlated with other CO surrogates like AVO2, ScVO2, and lactate in pediatric patients undergoing ICR for TOF.
Outcome of Obstructed Total Anamalous Pulmonary Venous Connection (TAPVC) Repair Patients with Milrinone Versus Milrinone and Inhaled Nitric Oxide (INO): A Prospective Randomized Observational Study
Authors: Gujja Srikanth , Prajapati Mrugesh , Chuada Tanya R , Gandhi Hemang , Arora Varun , Kaul Vivek , Patel Sanjay 
Published: June 2023

ABSTRACT

Background:
Obstructed total anomalous pulmonary venous connection (TAPVC) typically present with severe cardiovascular decompensation and requires urgent surgical management. Pulmonary arterial hypertension (PAH) is a major risk factor affecting mortality. Perioperative management focuses on providing inotropic support and managing potential pulmonary hypertensive episodes. Milrinone and inhaled nitric oxide (iNO) efficiently reduce pulmonary artery pressure (PAP) and help to improve the outcome. The aim was to determine the outcome of patients with high PAP with milrinone alone and a combination of iNO and milrinone.

Material and Method:
After ethical committee approval, the study was conducted over a period of 3 years in 80 patients with obstructed TAPVC repair. A total of 80 patients having severe PAH (supra systemic arterial pressure) randomly divided into two groups with 40 patients in each (M & MN). Group M (milrinone) patients received milrinone and Group MN (milrinone & iNO) patients received both milrinone (after opening aortic cross clamp) and iNO (post operative ICU). Ventilation time, hospital stay, ICU stay, complications, in hospital mortality were compared between both groups.

Result:
Ventilation time, Intensive Care Unit (ICU) stay, hospital stay for group M was 8.02 ± 5.74 days, 11.25 ± 7.33 day, 14.92 ± 8.55 days, respectively, and for group MN was 5.02 ± 1.78 days, 8.27 ± 3.24 days, 10.3 ± 3.18 days, respectively. In hospital mortality for group M and MN was 10% and 2.5%, respectively. P value for each variable was significant < 0.05 (except mortality).

Conclusion:
Most of the patients with obstructed TAPVC had severe PAH. Management of severe PAH with a combination of milrinone with iNO had a better outcome than milrinone alone.
Bibliometric Analysis of the Worldwide Scientific Production on COVID-19 Infection and Cerebrovascular Disease
Authors: Palomino-Leyva Camila , Rivera-Recuenco Jhonny , Fernandez-Giusti Alicia , Barja-Ore John , Retamozo-Siancas Yesenia , Mayta-Tovalino Frank 
Published: June 2023

ABSTRACT

Objective:
To identify the worldwide bibliometric characteristics of research on SARS-CoV-2 infection and cerebrovascular disease.

Methods:
A retrospective, descriptive, and bibliometric study was performed. We analyzed 1834 publications about COVID-19 and cerebrovascular disease from the Scopus database considering the time since the beginning of the pandemic between 2019 and 2020. Bibliometric indicators were evaluated such as number of citations, citations per publication by authors, countries, journals, and collaborations at national, international, institutional, and impact levels according to Cite Score Quartile and h-index metrics. All analysis was performed using SciVal software.

Results:
The highest percentage of articles corresponded to universities in the United States, including Harvard and New York with 59 and 20 publications, respectively, and the University of Toronto in Canada with 22 publications. In relation to citation indicators, journals such as Stroke and Journal Stroke and Cerebrovascular diseases obtained 1971 and 561 citations, respectively. Regarding collaboration indicators, the national collaboration index was 39.4% and the institutional collaboration index was 31.1%. Finally, neurology, cardiovascular medicine, and cardiology and surgery were the subject areas with the highest research results, with 424, 217, and 128 studies, respectively.

Conclusion:
It was observed that the United States was the country with the highest scientific production on COVID-19 and cerebrovascular disease in the year 2020 in the different health areas; however, more research is still needed worldwide for a better analysis of the bibliometric indicators on the subject.