bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hyponatraemia-induced Takotsubo syndrome secondary to idiopathic syndrome of inappropriate antidiuretic hormone: a case report
Authors: López-Trejo Felipe Israel , Cedillo-Urbina Martin Rodrigo , Maldonado-Tenesaca Andrea Paulina , Rivera-Guerrero Juan Carlos , Andrade-Cuellar Elias Noel 
Published: January 2025

Abstract

Background
Takotsubo cardiomyopathy (TC), also known as stress cardiomyopathy or broken-heart syndrome, is an acute, reversible left ventricular dysfunction often triggered by stress and associated with elevated catecholamine levels. Hyponatraemia has been recognized as a potential trigger for TC, although its pathophysiological mechanisms remain unclear.

Case summary
We present the case of an 84-year-old woman with a history of Type 2 diabetes, primary hypertension, hypothyroidism, and osteoporosis, who was admitted for typical angina and seizures. Initial laboratory tests revealed severe hyponatraemia (serum sodium: 119 mmol/L) and elevated cardiac enzymes. Electrocardiogram showed Wellens Type B syndrome and subsequent ST-segment elevation. Coronary angiography revealed no significant coronary lesions. Optical coherence tomography showed a non-significant lesion in the anterior descending artery, and ventriculography confirmed TC. The patient was treated with beta-blockers and managed for syndrome of inappropriate antidiuretic hormone-induced hyponatraemia with fluid restriction. Follow-up echocardiography at three months showed recovery of global longitudinal strain and preserved biventricular systolic function. Cardiac magnetic resonance imaging demonstrated normal chamber dimensions and late gadolinium enhancement with a non-ischaemic pattern.

Discussion
This case underscores the association between severe hyponatraemia and TC, highlighting the need for careful electrolyte management in patients with acute cardiac symptoms. The exact mechanisms linking hyponatraemia and TC remain to be elucidated, but this case contributes to the limited literature on hyponatraemia-induced TC, emphasizing the importance of recognizing and addressing this electrolyte imbalance to prevent cardiac complications.
Roundtable: Paris 2024 Olympic and Paralympic Games
Authors: Alouane Rim-Sarah , De Oliveira Patrick Luiz Sullivan , Doria Corinne , Ervine Jonathan , Gillett Rachel Anne , Graham-Goering Erika , Levett Geoffrey , Lewis Robert W , Smith Andrew W M , Wardhaugh Jessica , Eldridge Claire 
Published: January 2025

Abstract
One hundred years after Paris last hosted, the Olympic and Paralympic Games were held in the French capital this summer. To mark this centenary, French History gathered a group of academics together to write blog posts in response to different aspects of Paris 2024. Their posts, which were originally hosted on the French History Network Blog, invited readers to delve into the historical, cultural and sporting references being evoked by the opening ceremonies; to analyse the ways the Games were being used as a vehicle for wider political messages about France and its place in the world; and to reflect on the relationship between the images of France as projected through the Games and realities on the ground. We have collated the blog posts here, lightly edited and updated to reflect conclusion of the Games, and hope readers will enjoy reminding themselves of this very memorable French summer.
Nuclear and Mitochondrial Genome Assemblies for the Endangered Wood-Decaying Fungus Somion occarium
Authors: Hill Rowena , McGowan Jamie , Brabcová Vendula , McTaggart Seanna , Irish Naomi , Barker Tom , Knitlhoffer Vanda , Lucchini Sacha , Baker Kendall , Catchpole Leah , Watkins Chris , Gharbi Karim , Kaithakottil Gemy , Tracey Alan , Wood Jonathan M D , Tomšovský Michal , Baldrian Petr , Swarbreck David , Hall Neil 
Published: January 2025

Abstract
Somion occarium is a wood-decaying bracket fungus belonging to an order known to be rich in useful chemical compounds. Despite its widespread distribution, S. occarium has been assessed as endangered on at least 1 national Red List, presumably due to loss of old-growth forest habitat. Here, we present a near-complete, annotated nuclear genome assembly for S. occarium consisting of 31 Mbp arranged in 11 pseudochromosomes—9 of which are telomere-to-telomere—as well as a complete mitochondrial genome assembly of 112.9 Kbp. We additionally performed phylogenomic analysis and annotated carbohydrate-active enzymes (CAZymes) to compare gene and CAZyme content across closely related species. This genome was sequenced as the representative for Kingdom Fungi in the European Reference Genome Atlas Pilot Project.
How Neighborhood Social Deprivation Is Associated With Nursing Home Quality: A Structure, Process, Outcome Model
Authors: Pradhan Rohit , Lord Justin , Orewa Gregory , Davlyatov Ganisher , Weech-Maldonado Robert 
Published: January 2025

Abstract

Background and Objectives
Nursing home (NH) quality often varies across socioeconomic gradients. The purpose of this study was to explore the relationship between social deprivation and NH quality.

Research Design and Methods
Integrating resource dependence theory with Donabedian’s structure-process-outcome model, this study utilized 2019 data from Payroll Based Journal, Care Compare: Five-Star Quality Rating System, and LTCFocus.org. The analytic file included 12,900 free-standing NH observations. The primary variable of interest was severe social deprivation index (SDI) defined as SDI ≥85/100. Structural equation modeling was used to explore the effects of severe deprivation on NH structural (nursing staff), processes (antipsychotic medications [APMs]), and outcomes (falls, pressure ulcers, activities of daily living [ADL] decline, and hospitalizations) quality indicators among long-stay NH residents.

Results
Nursing homes in communities with severe SDI showed a decrease of 0.02 registered nurse (RN) hours per resident day (PRD) (p &lt; .001) and an increase of 0.03 certified nursing assistant (CNA) hours PRD (p = .01). Higher licensed practical nurse (LPN) hours PRD (β = −1.03; p = .003) and higher CNA hours PRD (β = −0.80; p &lt; .001) were significantly associated with reduced APM use. Increased APM use was significantly associated with ADL decline (β = 0.03; p &lt; .001) and hospitalizations (β = 0.001; p = .013). Severe SDI indirectly resulted in higher hospitalizations (β = 0.01; p = .01) and falls (β = 0.01; p = .001) through lower RN staffing but lower pressure ulcers (β = −0.07; p &lt; .001) through higher CNA staffing. Directly, severe SDI increased pressure ulcers (β = 0.69; p &lt; .001) and hospitalizations (β = 0.09; p &lt; .001) and decreased falls (β = −0.53; p &lt; .001).

Discussion and Implications
Severe social deprivation affected nursing staff patterns, affecting care quality. These findings highlight the importance of considering environmental factors in the NH quality policymaking process.
Oscillation frequencies of long-period seismic events at Kusatsu–Shirane volcano, Japan, related to the volume of water vapour in a hydrothermal crack
Authors: Nakano Masayuki , Kumagai Hiroyuki , Taguchi Kimiko 
Published: January 2025

SUMMARY
Long-period (LP) seismic events at active volcanoes are characterized by damped harmonic oscillations, which are thought to be generated by resonances in fluid-filled cracks. LP source properties (crack geometry and fluid properties) are generally estimated by analytically calculating the ratios of spectral peaks in crack resonance frequencies and empirically calculating a quality (Q) factor. However, because this method is applicable only to LP events with more than four spectral peaks, we cannot use it to analyse LP events with fewer spectral peaks. To bridge this gap, we developed a new method to estimate source properties using the frequency (f), Q factor and seismic moment (M0) of the lowest spectral peak of an LP event. We assumed misty gas (water vapour containing small water droplets) as the fluid in the crack and analytically derived the geometrical relationships of the crack. M0 was estimated from observed amplitudes of the lowest spectral peaks at different stations using an assumed crack mechanism. We applied this method to LP events observed from 1989 to 1993 at Kusatsu–Shirane volcano, Japan. We found that the crack length was quite variable, but the crack width was almost constant at around 100 m during our study period. We also found a strong correlation between the inverse of f and the total mass of water in the crack, which can be explained theoretically using the acoustic properties of misty gas and crack geometrical relationships. The total mass of water is proportional to the volume of water vapour in the crack, and the water vapour has been interpreted to be derived from magmatic degassing at depth. The oscillation frequency of the LP event is thus a useful metric for monitoring magma degassing into the shallow hydrothermal system, which is an important constraint on the occurrence of phreatic eruptions. Because our simple approach is widely applicable to LP events, it can enable improved monitoring of hydrothermal activity and evaluation of the risk of phreatic eruptions.
Hyperoside improves the growth of Saccharomyces cerevisiae cells under copper stress via decreasing reactive oxygen species
Authors: Du Gang , Sun Cunying , Zheng Kaifang , Sun Mingyue , Yang Zihan , Meng Dan , Li Bingjuan , Guan Wenqiang , Zhao Hui 
Published: January 2025

Abstract
Copper irons are widely applied in vineyards as pesticides (commonly referred to as Bordeaux mixture). However, excess copper is toxic to cells and to human health. Organisms have developed sophisticated molecular mechanisms in response to copper stress. In Saccharomyces cerevisiae, transcription factor Ace1 is activated and regulates CUP1, CRS5, and SOD1 in response to copper stress. Hyperoside (HYP) is mainly used in clinical treatment and healthcare products due to its ability to reduce intracellular reactive oxygen species (ROS). In this work, HYP, when compared with a conventional control, dramatically improved the growth of S. cerevisiae cells in copper stress, even in CUP1 and SOD1 mutant cells, by significantly decreasing the levels of ROS. Furthermore, expression of CUP1, CRS5, and SOD1 was significantly reduced under copper stress with HYP. These results illustrate that HYP effectively improves the growth of S. cerevisiae cells under copper stress.
Methodology for accessing cyanogen glycoside and alkaloid content in Traditional foods
Authors: Hay Thomas Owen , Nastasi Joseph Robert , Turpin Gerry , Chapman Dale , Fredricks Bronwyn , Thompson Suzanne , Fitzgerald Melissa 
Published: January 2025

Abstract
This study aimed to assess the food safety of 8 Traditional Australian foods by analysing their cyanogen glycoside and alkaloid content. The research utilized a combination of ultra performance liquid chromatography-quadrupole time of flight tandem mass spectrometry, UV–Vis spectroscopy, and indicator strip assays to identify and quantify toxic compounds. The study found no cyanogen glycosides across all tested species above a limit of detection of 1.59 μg g−1 cyanide equivalent. Eight alkaloids were identified, including trigonelline, piperine, atropine, piperyline, corydine, cinchonine, corynoxiene, and desmotroposantonin. Notably, atropine, which was detected in trace amounts in native pepper, was found to be below the detection limit of 1.30 ± 0.60 mg per 100 g. The presence of trigonelline and piperine was significant in several species, particularly the native pepper. These findings suggest that the tested Traditional foods are safe for consumption concerning cyanogen glycosides and alkaloids. The systematic approach to toxin detection in these foods supports the use of Traditional knowledge, aids in validating their food safety, and provides a framework for future toxicological assessments.
Preservative effects of cumin (Cuminum cyminum) and black zira (Bunium persicum) essential oil emulsion-based gelatin coating on rainbow trout (Oncorhynchus mykiss)
Authors: Darvishi Fatemeh , Moosavi-Nasab Marzieh , Khoshnoudi-Nia Sara , Oliyaei Najmeh 
Published: January 2025

Abstract
In this study, gelatin-based edible coatings loaded with Cuminum cyminum essential oil (CEO) and/or Bunisum persicum essential oil (BEO) emulsions were fabricated and their effect on extending the shelf life of whole ungutted rainbow trout fish was investigated. The physicochemical, microbial, and sensory properties of the fish during 20 days of storage were examined. The gas chromatography (GC) analysis of EO components revealed that cuminaldehyde (31.36%) and gamma-terpinene (36.12%) were the major components of CEO and BEO, respectively. The total viable, psychrophilic, and lactic acid bacteria count of samples treated with active edible coatings were significantly lower than those coated with gelatin and control samples. The highest and lowest pH values were obtained for the control sample (6.87) and the samples containing CEO (6.40), respectively. The lowest thiobarbituricacid reactive substances and total volatile basic nitrogen values were obtained in fish coated with gelatin containing 1.5% CEO and BEO. The best sensory score was achieved for the sample treated with both EOs. Therefore, using gelatin coating loaded with CEO and BEO can improve the shelf life of fish.
Exploring the antimicrobial potentials and thermal stability of bovine lactoferrin against foodborne pathogens
Authors: Khatoon Ammarah , Khan Usman Mir , Kaur Manpreet 
Published: January 2025

Abstract
The study was conducted to analyze the antimicrobial activity and the sensitivity of bovine lactoferrin against foodborne pathogens and to evaluate the pH range and thermal stability of bovine lactoferrin. The agar well diffusion test was used to check the antimicrobial activity of each pathogen. Bacterial samples were purified and confirmed by biochemical tests. Three concentrations of lactoferrin 0.5, 1, and 10 mg/ml were evaluated for antibacterial activity against Escherichia coli, Salmonella enteritidis, and Staphylococcus aureus. Our results indicated that all three pathogenic bacteria were inhibited, even at 0.5 mg/ml (p &lt; .05). E. coli was the most sensitive, and S. aureus was the least sensitive. Lactoferrin remains effective at 6, 7, 8, and 9 pH, but no inhibition showed at 3, 4, and 5 pH (p &lt; .05). Lactoferrin showed no change at a pasteurization temperature of 60–75 °C (p &lt; .05) but was inactivated at higher temperatures. The results showed that lactoferrin can inhibit E. coli, S. enteritidis, and S. aureus from growth and remain unchanged at pasteurization temperature and pH ranges of 6–9.
Nutritional composition, antioxidant potential, physical characteristics, overall acceptance, and in vitro glycaemic index of cookies fortified with rambutan (Nephelium lappaceum L.) seed powder
Authors: Nguyen Thi Ngan , Tran Thi Thu Tra , Le Van Viet Man 
Published: January 2025

Abstract
Rambutan seeds are a by-product of the fruit processing industry. In this research, wheat flour was partially replaced by rambutan seed powder in a cookie recipe and the influence of this replacement on the product quality was examined. When increasing the rambutan seed proportion and reducing the unsalted butter ratio in the cookie recipe, the lipid content was unchanged; the ash, dietary fibre, phenolic, and saponin contents of the product were significantly enhanced while the starch and protein contents gradually decreased. The use of rambutan seed powder slightly improved monounsaturated fatty acids level but reduced polyunsaturated fatty acids content in the cookies. At the proportion of 30% and 40% rambutan seed powder, the obtained cookies had lower hardness and breaking strength but greater overall acceptance than the control cookie. The partial replacement of wheat flour by rambutan seed powder efficiently decreased in vitro glycaemic index of the product.
Development of omega-3 fortified stirred yoghurt with enhanced sensory and oxidative qualities through the addition of fish oil nanoemulsion and fruits
Authors: Shanuke D S , Edirisinghe E M R K B , Marapana R A U J , Hettiarachi S 
Published: January 2025

Abstract
The application of fish oil as a source of omega-3 in food fortification is limited due to its undesirable strong flavours, odour, and susceptibility to rapid oxidation. This study aimed to develop functional yoghurt with omega-3 using fish oil with improved oxidative stability and organoleptic characteristics and evaluate its characteristics during storage for 21 days. Fish oil nanoemulsion and soursop (Annona muricata L.) added stirred yoghurt (FOESY) showed the highest omega-3 content after storage, with a significant reduction in syneresis, total oxidation (TOTOX) and acidity compared to bulk fish oil fortified stirred plain yoghurt (FOPY) and bulk fish oil fortified stirred soursop yoghurt. FOESY showed the highest retention of total eicosapentaenoic acid and docosahexaenoic acid at 71.75 ± 2.84%. FOPY had the highest (p &lt; .05) TOTOX of 20.95 ± 4.25 after 14 days. Therefore, this study reveals the potential of producing fish oil-added yoghurt as an omega-3 delivery food.
Effects and improvements of storage conditions and processing on the bioaccessibility and bioavailability of phytochemicals in fruits and vegetables
Authors: Jia Hanbing , Ren Feiyue , Liu Hongzhi 
Published: January 2025

Abstract
Phytochemicals found in fruits and vegetables offer health benefits for degenerative diseases, but their bioaccessibility are often limited due to poor stability. Various environmental conditions such as temperature, moisture, pH, as well as different processing methods, significantly impact phytochemicals. These factors are becoming increasingly important in the food industry and are attracting the attention of many researchers. This review examines the advantages and disadvantages of mechanical processing, thermal processing, and non-thermal processing and their effects on content, bioaccessibility, antioxidant activity, and sensory properties of phytochemicals. Non-thermal processing is considered to have the potential to replace traditional thermal processing due to its lesser degradation of phytochemicals. The operations and effects of various non-thermal processing techniques, including high-pressure processing, high-pressure homogenization, pulsed electric field, ultrasound, supercritical carbon dioxide, cold atmospheric plasma, bioprocessing, and encapsulation, are reviewed. The aim of this review is to provide the latest information on processing for future research and innovation.
The effects of soybeans and its derivatives on oral diseases: a narrative review
Authors: Canyan Kuang , Arias Zulema Rosalia , Omori Kazuhiro , Yamamoto Tadashi , Shinoda-Ito Yuki , Takashiba Shogo 
Published: January 2025

Abstract
Soybean is a widely utilized protein source that originated in China and has been associated with preventing and treating various diseases. Soy protein has been found to inhibit fat accumulation effectively, and soybeans contain isoflavones, saponins, phytic acid, and other substances with preventive and therapeutic effects on heart disease, cancer, and diabetes. Furthermore, processed soybean products, such as Avocado-Soybean unsaponifiable, Tempeh, and Bowman-Birk inhibitor, have demonstrated health benefits. These products have been shown to have antibacterial, antioxidant, and anticancer effects in oral diseases. Numerous experiments have provided evidence of the antibacterial, antioxidant, and anticancer effects of polyunsaturated fatty acids, isoflavones, and soybean polypeptides. This comprehensive review assesses the relationship and mechanism of soybeans and their derivatives on oral diseases, providing valuable insights into their prevention and treatment.
Field verification of food quality monitoring in the cold chain by using a laccase time–temperature indicator label
Authors: Lin Ya-Chin , Chen Shih-Hsin , Lin Shih-Bin , Chen Hui-Huang 
Published: January 2025

Abstract
This study developed a laccase time–temperature indicator label (LTTIL) by immobilising laccase on electrospun fibres to form the LTTI film and reacted with guaiacol solution for colouration. Field verification was performed to validate the function of the LTTIL in monitoring food quality changes in the cold chain under temperature fluctuations. The time required to reach a total plate count of 6 log CFU/g was regarded as the critical point of fresh-cut cucumber (FCC) deterioration (CPTPC). A critical point of LTTIL colouration (CPLTTIL) was also set to indicate the significantly darker reddish brown of LTTIL. The field verification experiment revealed that when the LTTIL with 0.10 mM NaN3 was applied, the CPLTTIL was attained at 132.8 hr after the start of an experiment, whereas the CPTPC was attained at 139.2 hr, resulting in a low prediction error of approximately 4.6%. Therefore, the LTTIL is considered to be effectively used to monitor FCC quality changes in the cold chain and accurately evaluate their freshness.
Flavonoids of probiotic fermented plant beverage FH03F: potential antiobesity mechanisms: integrating metabolomics, network pharmacology, and molecular docking
Authors: Wang Ting , Yang Yunhan , Liang Honglian , Yu Yuanyuan , Wang Haoming , Wu Xiurong , Su Miaoting , Wang Jinghan , Yan Xiantao 
Published: January 2025

Abstract
Flavonoids can ameliorate lipid metabolism and prevent obesity. FH03F is a probiotic fermented plant beverage that is rich in flavonoids, but its antiobesity mechanism is not clear. This study aimed to explore the differences in flavonoids in FH03F after fermentation and its potential antiobesity mechanism via metabolomics, network pharmacology, and molecular docking. Metabolomics analysis revealed significant changes in FH03F flavonoids via fermentation, and 91 flavonoids were detected. Through network pharmacology, 28 flavonoids met the efficacious screening criteria, and 4 targets were core targets. Molecular docking revealed that quercetin, wogonin, and luteolin had lower binding energies with core targets than the other compounds did. In summary, FH03F flavonoids mainly exert antiobesity effects by regulating TP53, AKT1, IL6, and TNF expression, and regulating the AGE–RAGE signalling pathway in diabetic complications and other pathways, which means that FH03F flavonoids exert antiobesity effects through multiple components, multiple targets, and multiple pathways.
Stabilisation of groundnut oil with gallic acid and leaf extracts of Lonchocarpus sericeus and Lonchocarpus cyanescens
Authors: Falade Olumuyiwa Sunday , Afolabi Funmilayo Patricia , Aderogba Mutalib Adeniran , Adeyanju Ayotunde Adeyemi , Ajayi Olukayode Solomon 
Published: January 2025

Abstract
This study evaluated the antioxidant properties of two Lonchocarpus species leaf extracts. It also profiled the phenolic constituents of their active fractions using HPLC. Of the four solvent fractions obtained, ethyl acetate of Lonchocarpus cyanescens (LC) had the highest antioxidant activity (metal chelating ability [IC50], 2,2-diphenyl-1-picrylhydrazyl hydrate [IC50], ferric reducing antioxidant power, total antioxidant capacity, total flavonoid content, and total phenolic content with 0.673 ± 0.061 μg/ml, 0.245 ± 0.007 μg/ml, 177.6 ± 3.7 mg AAE/g, 202.5 ± 3.6 mg AAE/g, 1,323.1 ± 16.7 μg CE/g, and 1244.3 ± μg GAE/g values, respectively). Processing of the groundnut oil was observed to compromise its natural defence system. Gallic acid was the best of the three antioxidant agents used to stabilise groundnut oil followed by the ethyl acetate fraction of LC, and butylated hydroxyanisole (BHA) the least. It can be concluded that gallic acid and ethyl acetate fraction of LC could be used to replace BHA implicated in aetiology of cancer but safety and acceptability of their use in vegetable oil should be investigated.