bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neutrophil Lymphocyte Ratio as a Prognostic Factor in Acute Pancreatitis
Authors: Dey Anjan Kumer , Ahmed Farid Uddin , Paul Sujat 
Published: June 2023

Background: Different scoring systems are currently in use to stratify the severity of the acute pancreatitis to guide clinicians in triaging patients with the aim of improving outcomes. The Neutrophil-Lymphocyte Ratio (NLR) provides a rapid indication of the extent of an inflammatory process. Its value to predict the severity of acute pancreatitis has not been well studied. The aim of this study was to investigate the prognostic value of the NLR in acute pancreatitis patients.
Materials and methods: This hospital based observational study was conducted at Medicine ward of Chittagong Medical College Hospital (CMCH) for one year period from January 2015 to December 2015. One hundred and four adult patients with a diagnosis of acute pancreatitis who fulfilled the defined inclusion and exclusion criteria were selected for the study. After obtaining informed consent clinical interviewing and physical examination were done according to predesigned case record form. Then blood was collected within one hour of admission. After getting the result, final selection were done following exclusion criteria. The patients were arranged into three groups according to NLR tertiles. Main outcome measures were intensive Care Unit (ICU)/High Dependency Unit (HDU) admission, Length of Stay (LOS) in the hospital and in-hospital mortality.
Results: According to NLR tertiles, patients in the 3 tertile (NLR³7.6) had significantly more ICU/HDU admissions (40.6% vs. 0%), longer average LOS (7.91 vs. 4.03 days) and more death (12.5% vs. 0%) compared with those in the 1rd tertile (NLR< 3.6). The higher the NLR tertile, the Modified Early Warning Score (MEWS) also increased significantly. According to the ROC curve, NLR values were superior in predicting ICU/HDU admission and hospitalization for ³ 7 days compared to WBC and MEWS values.
Conclusion: Elevation of the NLR during admission was significantly associated with severe acute pancreatitis and is a negative prognostic indicator in acute pancreatitis. It is superior to total WBC and modified MEWS in predicting adverse outcomes of acute pancreatitis.
JCMCTA 2020 ; 31 (1) : 90-95
Unusual Location of Intraperitoneal Fibromyoma: Rarity Does Not Rule Out the Diagnosis
Authors: Nessa Kamrun , Das Suchanda , Begum Shahana , Akhter Salma 
Published: June 2023

Fibromyoma which is commonest benign tumor mostly arises from smooth muscles of uterus present in 20-25% women of reproductive age group. Round ligament Fibromyoma is rare tumor & exact incidence not known. It may mimic ovarian tumor when it was intra peritoneal and located in adnexa. Preoperative diagnosis can be made by history, clinical examination, USG, CT scan of abdomen. Surgical excision is the curative treatment. A 35 years lady para 2 presented with lump in lower abdomen gradually increasing in size for 3-4 yrs and pain for 2 months. On examination firm palpable mass of 28 weeks pregnancy size. Her USG and CT scan detected well defined 28 cm x 22 cm X 20 cm mass in right adnexa & diagnosis given ovarian tumor. Her CA 125 level was 97unit/ml. Laparotomy finding was a big firm lobulated tumor arises from right round ligament. Tumor removed as a whole, uterus, both ovaries, and left sided fallopian tube healthy & preserved. Final histopathological diagnosis benign fibromyoma with degenerative change. So diagnosis of fibromyoma always kept in mind during the differential diagnosis of any pelvic mass.
JCMCTA 2020 ; 31 (1) : 130-133
Ectopic Cushing’s Syndrome From Prostatic Adenocarcinoma: A Rare Clinical Entity
Authors: Chowdhury Rezaul Haider , Chowdhury Sumon Rahman , Tanzil Tasnuva , Alam Md Minhazul 
Published: June 2023

A 61-year-old man known to have metastatic prostate adenocarcinoma was seen at Changi General Hospital, Singapore, because of severe hypokalaemia due to ACTH dependent Cushing’s syndrome. He underwent a Dotate PET CT which showed increased DOTA-NOC-avidity in the right side of the prostate gland. Subsequent immunohistochemical staining of prostate biopsy sample documented ACTH, synaptophysin and CD 56 positivity. He was suggested medical management for prostate cancer complicated by Cushing's syndrome. Unfortunately, Cushing’s syndrome was not controlled and the patient’s clinical condition progressively worsened. Subsequently, he developed fatal sepsis due to immunocompromised state. This case report describes a case of Cushing’s syndrome due to metastatic adenocarcinoma of the prostate, a tumour with very few therapeutic options and negative prognosis.
JCMCTA 2020 ; 31 (1) : 125-129
Penerapan Data Envelopment Analysis dalam Pengukuran Efisiensi Teknis Produktivitas Tanaman Jeruk di Kabupaten Sleman
Authors: Hardiyan  , Yunita  , Junaidi Agus , Agus Sobari Irwan 
Published: June 2023

Indonesia mempunyai potensi pasar yang baik untuk komoditas jeruk, salah satunya di Sleman. Sleman merupakan kabupaten yang berada di lereng Gunung Merapi, sebagian besar tanahnya digunakan sebagai lahan pertanian. Jeruk adalah salah satu komoditas unggulan hortikultura dapat tumbuh dan berproduksi di dataran rendah sampai dataran tinggi. Di Kabupaten Sleman, untuk produksi jeruk belum dapat terpenuhi, sehingga harus mendatangkan jeruk dari wilayah lain. Oleh karenanya diperlukan pendekatan Data Envelopment Analysis bertujuan untuk mengukur efisiensi relatif teknik produktivitas tanaman jeruk di Kabupaten Sleman. DMU didasarkan pada perbandingan data tahunan dari 2017 hingga 2021 mengacu pada data yang homogen. Pengukuran efisiensi teknis produktivitas tanaman menunjukkan tren positif kembali di tahun 2021, dimana menunjukkan pencapaian dengan tingkat efisiensi relatif mencapai 100% atau bernilai 1, sehingga dapat menjadi acuan untuk tahun-tahun berikutnya.
Efficacy of LAMP assay for Mycobacterial spp. detection to prevent treatment delays and onset of drug resistance: a systematic review and meta-analysis
Authors: Bumbrah Gurvinder Singh , Jain Sarika , Fatima Zeeshan , Hameed Saif 
Published: June 2023

Background: Tuberculosis (TB) remains a deadly disease affecting one-third population globally. Long turnaround time and poor sensitivity of the conventional diagnostics are the major impediments for faster diagnosis of Mycobacterial spp to prevent drug resistance. To overcome these issues, molecular diagnostics have been developed. They offer enhanced sensitivity but require sophisticated infrastructure, skilled manpower and remain expensive.
Methods: In that context, loop-mediated isothermal amplification (LAMP) assay, recommended by the WHO in 2016 for TB diagnosis, sounds as a promising alternative that facilitates visual read outs. Therefore, the aim of the present study is to conduct a meta-analysis to assess the diagnostic efficiency of LAMP for the detection of a panel of Mycobacterium spp. following PRISMA guidelines using scientific databases. From 1600 studies reported on the diagnosis of Mycobacterium spp., a selection of 30 articles were identified as eligible to meet the criteria of LAMP based diagnosis.
Results: It was found that most of the studies were conducted in high disease burden nations such as India, Thailand, and Japan with sputum as the most common specimen to be used for LAMP assay. Furthermore, IS6110 gene and fluorescence-based detections ranked as the most used target and method respectively. The accuracy and precision rates mostly varied between 79.2% to 99.3% and 73.9% to 100%, respectively. Lastly, a quality assessment based on QUADAS-2 of bias and applicability was conducted.
Conclusion: LAMP technology could be considered as a feasible alternative to current diagnostics considering high burden for rapid testing in low resource regions.
Komunikasi Informasi Motivasi dan Edukasi tentang Stunting kepada Keluarga Berisiko Stunting dan Calon Tim Pendamping
Authors: Patimah Sitti , Sharief Suchi Avnalurini , Rahman Harpiana , Nukman Nukman 
Published: June 2023

West Sulawesi Province is the second highest the prevalence of stunting in Indonesia. Polman Regency has the highest in West Sulawesi (36%), so prevention efforts are needed through mentoring to groups at risk of stunting and and family support officers.This community service aims toassess the effectiveness of mentoring on knowledge, attitudes and self-efficacy of families at risk of stunting and candidate for family mentoring in stunting prevention efforts. Mentoring was provided to young women, pregnant women and mothers with toddlers, and prospective family support team officers (28 people) using the communication, information, motivation and education (CIME) method regarding the problem of malnutrition and its impacts, midwifery care for at-risk groups, as well as perspectives Islam about the role of the family in creating children without stunting.Test was conducted before and after mentoring, then analyzed using the McNemar and wilcoxon test. There were 10.7% had never heard of stunting, and 89.3% of the participants knew the term stunting as a short child and experienced growth and development disorders. There was an increase of participants' knowledge scores by 2.25 points significanly (p=0.010), sufficient knowledge was 10.7% (p=0.549), positive attitudes by 3.5% (p=1,000), and high self-efficacy by 28.6% (p=0.008). It was concluded that mentoring on participants had a positive effect on improving knowledge, attitudes, and self-efficacy in stunting prevention.
Sosialisasi Modul Edukasi Suami Siaga (ESS) tentang Pencegahan Stunting pada Suami Ibu Hamil Primigravida
Authors: Marsia Marsia , Juniartati Erni , Sulistyawati Dwi 
Published: June 2023

Stunting or short stature is a major health problem in Indonesia. Stunting can cause cognitive development disorders in toddlers. Standby husband education (ESS) is one of the educational solutions offered to prevent stunting in babies carried by mothers during pregnancy. This community service aims to increase knowledge and develop attitudes in the working area of ​​the North Singkawang Health Center 1. The sample in this study was 40 Respondents of husband of a primigravida pregnant woman undergoing treatment at the Singkawang Utara I Public Health Center. This Community Service was carried out within a span of 10 months from the preparation of proposals, permits, field surveys, interventions, data analysis to the collection of reports. The implementation of community service is evaluated based on the level of knowledge and attitude in efforts to prevent stunting using a knowledge and attitude questionnaire. The results of the knowledge level of the respondents after being given socialization as big 65% with a good level of knowledge and 35% with a fairly good level of knowledge. The attitude of the respondents after being given socialization as big 100% with a positive attitude category. The expected results of this community service are as a reference for programs at the Public Health Center / Health Office in an effort to prevent stunting.
Lipids, lipid-lowering agents, and inflammatory bowel disease: a Mendelian randomization study
Authors: Tao Heqing , Yu Zhou , Dong Yongqiang , Liu Ligang , Peng Liang , Chen Xueqing 
Published: June 2023

BackgroundTo assess the causal role of lipid traits and lipid-lowering agents in inflammatory bowel disease (IBD).MethodsUnivariable mendelian randomization (MR) and multivariable MR (MVMR) analyses were conducted to evaluate the causal association between low-density lipoprotein cholesterol (LDL-C), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C) and IBD. Drug-targeted MR analyzed the effects of lipid-lowering drugs on IBD, and network MR was used to analyze potential mediation effects.ResultsThe levels of HDL-C had an inverse relationship with the risk of Crohn’s disease (CD, OR: 0.85, 95% CI: 0.73-0.98, P = 0.024). In MVMR, the inverse relationships were found in all three outcomes. Drug-targeted MR analyses showed that with one-SD LDL-C decrease predicted by variants at or near proprotein convertase subtilisin/kexin type 9 (PCSK9), the OR values of people diagnosed with IBD, ulcerative colitis (UC) and CD were 1.75 (95%CI: 1.13-2.69, P = 0.011), 2.1 (95%CI: 1.28-3.42, P = 0.003) and 2.24 (95%CI: 1.11-4.5, P = 0.024), respectively. With one-SD LDL-C decrease predicted by variants at or near cholesteryl ester transfer protein (CETP), the OR value of people diagnosed with CD was 0.12 (95%CI: 0.03-0.51, P = 0.004). Network-MR showed that HDL-C mediated the causal pathway from variants at or near CETP to CD.ConclusionOur study suggested a causal association between HDL-C and IBD, UC and CD. Genetically proxied inhibition of PCSK9 increased the risk of IBD, UC and CD, while inhibition of CETP decreased the risk of CD. Further studies are needed to clarify the long-term effect of lipid-lowering drugs on the gastrointestinal disorders.
Visual disability in neuromyelitis optica spectrum disorders: prognostic prediction models
Authors: Luo Wenqin , Kong Lingyao , Chen Hongxi , Wang Xiaofei , Du Qin , Shi Ziyan , Zhou Hongyu 
Published: June 2023

Background and objectivesNeuromyelitis optica spectrum disorder (NMOSD) is an autoimmune inflammatory disease of the central nervous system characterized by simultaneous or consecutive episodes of acute optic neuritis and transverse myelitis. Attacks of NMOSD can result in the accrual of severe visual disability over time. This study aimed to develop and validate prognostic models for visual disability risk within 1, 3, and 5 years.MethodsMedical records of NMOSD patients were retrospectively analyzed. The least absolute shrinkage and selection operator (LASSO) regression algorithm and univariate and multivariate Cox regression analyses were performed to select predictors of visual disability. Two models predicting the probability of visual disability in 1, 3, and 5 years were developed based on different selections and displayed as nomograms. Risk scores were calculated for every patient, and a cut-off point was obtained to recognize patients at high risk.ResultsIn total, 161 (25.2%) patients developed visual disabilities during the follow-up period. Four visual disability-related factors were selected using LASSO regression: optic neuritis (ON) onset, higher annual relapse rate (ARR) before maintenance therapy, no maintenance immune suppression therapy (IST), and initial severe attack. Three additional predictors were determined using multivariate Cox regression: male sex, age at first onset, and positive AQP4-IgG serology. Discrimination and calibration were satisfied, with concordance indexes (C-index) close to 0.9 in both models. Decision curve analysis showed good clinical usefulness in both models, and Kaplan-Meier curves showed satisfactory discrimination between patients with high risk and low risk by the cut-off points.ConclusionThis study reported predictors of visual disability and generated nomograms. High-risk patients need more active treatment and management to avoid unfavorable outcomes.
Mechanical and energy absorption properties of 3D-printed honeycomb structures with Voronoi tessellations
Authors: Ahmed Abdelrahman Mohamed Ragab M. , Mahdi Elsadig , Oosterhuis Kas , Dean Aamir , Cabibihan John-John 
Published: June 2023

3D printing technology is the new frontier in building construction. It is especially useful for making small structures within a short period. Full construction, including interior partitions and exterior façades, can be achieved with this technology. This paper proposes a parametric Voronoi tessellations model for quickly generating and fabricating 3D-printed hexagonal honeycomb partitions for interior design. Comprehensive experimental testing was conducted to characterize the mechanical properties and investigate the energy absorption characteristics of the proposed 3D-printed hexagonal honeycomb while comparing it to alternative hexagonal honeycomb structures. The tests included tensile testing (ASTM-D638) of the printed Polylactic Acid (PLA) material, especially with the almost total absence of conducted research that reported mechanical properties for 3D printed material with low infill percentages such as 10%. In addition, an in-plane quasi-static axial compression testing of the lightweight honeycomb structures was also conducted on the printed structure with the same low infill percentage. Compared to non-Voronoi honeycomb structures, the Voronoi honeycomb resulted in superior mechanical and energy absorption properties with energy absorption values ranging from 350 to 435 J and crash force efficiency being 1.42 to 1.65.
Branch-site occlusion sign predicts the embolic origin of acute ischemic stroke: a meta-analysis
Authors: Jiang Xinzhao , Shi Zongjie , Wang Peng , Wang Xu , Liu Fang 
Published: June 2023

ObjectiveThe study aimed to investigate whether branch-site occlusion (BSO) sign could predict the etiology of acute intracranial large artery occlusion (ILVO) and the stentriever (SR) response.MethodsWe systematically reviewed studies that evaluated the predictive role of BSO for the etiology of ILVO-AIS or EVT outcome between 1 January 2000 and 31 August 2022 from PubMed, Embase, and Web of Science.ResultsThe sensitivity and specificity of BSO sign predicting etiology of ILVO-AIS were 0.87 (95% CI 0.81–0.91) and 0.64 (95% CI 0.33–0.87), respectively. The sensitivity and specificity of BSO sign predicting stentriever response were 0.84 (95% CI 0.63–0.94) and 0.61 (95% CI 0.18–0.92), respectively.ConclusionThe BSO sign could be a valid and precise imaging marker to predict embolism caused ILVO-AIS and recanalization success by SR without rescue therapy.
A study on the immediate effects of enhanced external counterpulsation on physiological coupling
Authors: Liu Hongyun , Liang Hui , Yu Xiaohua , Han Yi , Wang Guojing , Yan Muyang , Wang Weidong , Li Shijun 
Published: June 2023

IntroductionEnhanced external counterpulsation (EECP) is a non-invasive assisted circulation technique for its clinical application in the rehabilitation and management of ischemic cardiovascular and cerebrovascular diseases, which has complex physiological and hemodynamic effects. However, the effects of EECP on the coupling of physiological systems are still unclear. We aimed to investigate the immediate effects of EECP on the coupling between integrated physiological systems such as cardiorespiratory and cardiovascular systems.MethodsBased on a random sham-controlled design, simultaneous electrocardiography, photoplethysmography, bio-electrical impedance, and continuous hemodynamic data were recorded before, during and after two consecutive 30 min EECP in 41 healthy adults. Physiological coupling strength quantified by phase synchronization indexes (PSI), hemodynamic measurements and heart rate variability indices of 22 subjects (female/male: 10/12; age: 22.6 ± 2.1 years) receiving active EECP were calculated and compared with those of 19 sham control subjects (female/male: 7/12; age: 23.6 ± 2.5 years).ResultsImmediately after the two consecutive EECP interventions, the physiological coupling between respiratory and cardiovascular systems PSIRES–PTT (0.34 ± 0.14 vs. 0.49 ± 0.17, P = 0.002), the physiological coupling between cardiac and cardiovascular systems PSIIBI–PTT (0.41 ± 0.14 vs. 0.52 ± 0.16, P = 0.006) and the total physiological coupling PSItotal (1.21 ± 0.35 vs. 1.57 ± 0.49, P = 0.005) in the EECP group were significantly lower than those before the EECP intervention, while the physiological coupling indexes in the control group did not change significantly (P &gt; 0.05).ConclusionOur study provides evidence that the PSI is altered by immediate EECP intervention. We speculate that the reduced PSI induced by EECP may be a marker of disturbed physiological coupling. This study provides a new method for exploring the mechanism of EECP action and may help to further optimize the EECP technique.
Consensus core outcome rating for the Japanese neonatal pain guidelines
Authors: Arimitsu Takeshi , Ozawa Mio , Gaughwin Kaori 
Published: June 2023

IntroductionThe Japanese Neonatal Pain Guidelines Committee, led by the Japan Academy of Neonatal Nursing, uses the Grading of Recommendations, Assessment, Development, and Evaluation Working Group method to evaluate the quality of evidence and the strength of treatment recommendations. Ratings on the importance of outcomes related to neonatal pain have not been reported. This study aimed to reach a consensus on the importance of outcomes through a guideline panel composed of doctors, nurses, a nurse practitioner, a physical therapist, and families to ensure consistency in systematic reviews of neonatal pain and future revisions to the guidelines.MethodsA total of 26 professionals, including 21 medical personnel from clinical settings and academia and 5 parents from five family associations, participated in 3-stage eDelphi rounds.ResultsThe literature review and discussion identified 75 outcomes that were included in round one. The participants proposed three additional outcomes: 78 outcomes were scored in rounds two and three. Round three scores showed different stakeholder groups in terms of priority outcomes. Seventeen outcomes were included in the final core outcome and were considered critical for decision-making.ConclusionCore outcomes of the development of neonatal pain guidelines in Japan were identified. The assessment process of importance from this study highlights the difference in the perspectives of medical providers and parents on neonatal pain, thus, involving parents in the assessment and as the spokesperson for the infant admitted to the neonatal intensive care unit is important for a more inclusive evaluation of pain prevention and management.