bluuebunny/crossref_metadata_2025_split huggingface dataset:
Auditory dyadic interactions through the “eye” of the
social brain: How visual is the posterior STS interaction
region?
Authors: Landsiedel Julia , Koldewyn Kami 
Published: July 2023

Abstract
Human interactions contain potent social cues that meet not only the eye but also the ear. Although research has identified a region in the posterior superior temporal sulcus as being particularly sensitive to visually presented social interactions (SI-pSTS), its response to auditory interactions has not been tested. Here, we used fMRI to explore brain response to auditory interactions, with a focus on temporal regions known to be important in auditory processing and social interaction perception. In Experiment 1, monolingual participants listened to two-speaker conversations (intact or sentence-scrambled) and one-speaker narrations in both a known and an unknown language. Speaker number and conversational coherence were explored in separately localised regions-of-interest (ROI). In Experiment 2, bilingual participants were scanned to explore the role of language comprehension. Combining univariate and multivariate analyses, we found initial evidence for a heteromodal response to social interactions in SI-pSTS. Specifically, right SI-pSTS preferred auditory interactions over control stimuli and represented information about both speaker number and interactive coherence. Bilateral temporal voice areas (TVA) showed a similar, but less specific, profile. Exploratory analyses identified another auditory-interaction sensitive area in anterior STS. Indeed, direct comparison suggests modality specific tuning, with SI-pSTS preferring visual information while aSTS prefers auditory information. Altogether, these results suggest that right SI-pSTS is a heteromodal region that represents information about social interactions in both visual and auditory domains. Future work is needed to clarify the roles of TVA and aSTS in auditory interaction perception and further probe right SI-pSTS interaction-selectivity using non-semantic prosodic cues.
Supporting optimal dietary behaviors in women with perinatal depression: A qualitative exploration of experiences, practices, and challenges
Authors: Klobodu Cynthia , Stott Dahlia , Chiarello Lisa A , Posmontier Bobbie , Elgohail Mona , Geller Pamela A , Horowitz June A , Milliron Brandy-Joe 
Published: July 2023

Background Women with perinatal depression (PD) are at high risk for unhealthy dietary behaviors and suboptimal child feeding practices. Despite evidence supporting the importance of healthful nutrition-related behaviors during and after pregnancy, few behavioral nutrition interventions for women with PD have been developed. The objectives of this study were to identify nutrition-related challenges and needs among women with PD and to elucidate the role that feeding plays in mother–infant interaction, to inform the development of nutrition interventions. Methods Using a qualitative study design, in-depth interviews were conducted with 18 mothers with a history of PD and 10 interdisciplinary healthcare providers with expertise in PD. Data were thematically analyzed using a hybrid inductive and deductive coding approach. Results Mean age of mothers was 31 ± 6 years, 56% identified as non-Hispanic White, and 33% identified as Black/African American. Eighty percent of healthcare providers practiced for more than five years. Six themes were identified: (a) Time scarcity mindset; (b) Importance of social support; (c) Unrealistic expectations of motherhood; (d ) Mom as the last priority; (e) Postpartum body changes and shape ideals; and (f) Contentment associated with infant and young child feeding. Conclusion Women with PD have several needs pertaining to their nutrition and that of their children. The findings from this study illustrate key considerations and recommendations for addressing these needs.
Protocolized proactive desmopressin plus 3% saline therapy for severe euvolemic hyponatremia in the wave of COVID-19: The local experience and the potential role of emergency departments
Authors: Cheung Jonathan Chun-Hei , Cheung Emmanuel Hei-Lok , Ho Laptin , Tse Chiu Lun , Yip Yu-Yeung , Lam Koon Ngai 
Published: July 2023

Background: Patients with severe euvolemic hyponatremia can be challenging to treat, and the COVID-19 pandemic has added to the complexity of the situation. Methods: Data were collected from all patients treated in a local intensive care unit (ICU) with the protocolized proactive desmopressin plus 3% saline (PD-3 S) approach in March 2022. Results: Six patients were treated with the protocol, whose initial serum sodium level (SNa) ranged from 98 to 108 mmol/L. SNa of one patient dropped further due to delayed initiation of protocolized PD-3 S because of access block. But otherwise, the protocol had been effective in achieving a controlled rise of SNa in all patients. No major complications have been observed, and the feedback from both medical and nursing staff was overall positive. Conclusion: This case series shows that the protocolized PD-3 S is safe and effective. This protocol is currently being used in two ICUs in our cluster. And our unit is currently working with the emergency department to initiate the protocol earlier, before ICU admission.
Continuous venovenous hemodiafiltration versus standard medical therapy for the prevention of rhabdomyolysis-induced acute kidney injury: a retrospective cohort study
Authors: Meng Yan , Zhou Ming-xue , Wu Chun-bo , Wang De-hua , Zhao Jian-rong , Shi Dong-yin 
Published: July 2023

Abstract
Aim
To determine whether continuous venovenous hemodiafiltration (CVVHDF) plus standard medical therapy (SMT) vs. SMT alone prevents rhabdomyolysis (RM)-induced acute kidney injury (AKI) and analyze the related health economics.

Methods
This retrospective cohort study involved 9 RM patients without AKI, coronary heart disease, or chronic kidney disease treated with CVVHDF plus SMT (CVVHDF + SMT group). Nine matched RM patients without AKI treated with SMT only served as controls (SMT group). Baseline characteristics, biochemical indexes, renal survival data, and health economic data were compared between groups. In the CVVHDF + SMT group, biochemical data were compared at different time points.

Results
At 2 and 7 days after admission, serum biochemical indices (e.g., myoglobin, creatine kinase, creatinine, and blood urea nitrogen) did not differ between the groups. Total (P = 0.011) and daily hospitalization costs (P = 0.002) were higher in the CVVHDF + SMT group than in the SMT group. After 53 months of follow-up, no patient developed increased serum creatinine, except for 1 CVVHDF + SMT-group patient who died of acute myocardial infarction. In the CVVHDF + SMT group, myoglobin levels significantly differed before and after the first CVVHDF treatment (P = 0.008), and serum myoglobin, serum creatinine, and blood urea nitrogen decreased significantly at different time points after CVVHDF.

Conclusions
Although CVVHDF facilitated myoglobin elimination, its addition to SMT did not improve biochemical indices like serum myoglobin, serum creatine kinase, creatinine, blood urea nitrogen, and lactate dehydrogenase or the long-term renal prognosis. Despite similar hospitalization durations, both total and daily hospitalization costs were higher in the CVVHDF + SMT group.
Partial ruptures of the distal triceps tendons show only slightly lower ultimate load to failure: a biomechanical study
Authors: Geyer Stephanie , Kadantsev Pavel , Bohnet Daniel , Marx Christian , Vieider Romed P. , Braun Sepp , Siebenlist Sebastian , Lappen Sebastian 
Published: July 2023

Abstract
Objective
Partial ruptures of the distal triceps tendon are usually treated surgically from a size of > 50% tendon involvement. The aim of this study was to compare the ultimate load to failure of intact triceps tendons with partially ruptured tendons and describe the rupture mechanism.

Methods
Eighteen human fresh-frozen cadaveric elbow specimens were randomly assigned to two groups with either an intact distal triceps tendon or with a simulated partial rupture of 50% of the tendon. A continuous traction on the distal triceps tendon was applied to provoke a complete tendon rupture. The maximum required ultimate load to failure of the tendon in N was measured. In addition, video recordings of the ruptures of the intact tendons were performed and analysed by two independent investigators.

Results
A median ultimate load to failure of 1,390 N (range Q0.25—Q0.75, 954 – 2,360) was measured in intact distal triceps tendons. The median ultimate load to failure of the partially ruptured tendons was 1,330 N (range Q0.25—Q0.75, 1,130 – 1.470 N). The differences were not significant. All recorded ruptures began in the superficial tendon portion, and seven out of nine tendons in the lateral tendon portion.

Discussion
Partial ruptures of the distal triceps tendon demonstrate a not statistically significant lower ultimate load to failure than intact tendons and typically occur in the superficial, lateral portion of the tendon. This finding can be helpful when deciding between surgical and conservative therapy for partial ruptures of the distal triceps tendon.
Physical activity and mental health in children and youth during COVID-19: a systematic review and meta-analysis
Authors: Li Bowen , Ng Kwok , Tong Xiuhong , Zhou Xiao , Ye Jiangchuan , Yu Jane Jie 
Published: July 2023

Abstract
Background
The coronavirus disease (COVID‐19) and universal mitigation strategies have fundamentally affected peoples’ lives worldwide, particularly during the first two years of the pandemic. Reductions in physical activity (PA) and increased mental health (MH) problems among children and youth have been observed. This systematic review and meta-analysis investigated the relationship between physical activity (PA) and mental health (MH) among children and youth during the COVID‐19 pandemic.

Methods
Four electronic databases (EMBASE, PsycINFO, PubMed, and Web of Science) were systematically searched to identify studies that (1) examined the relationship between PA and MH among children and youth (aged 2–24 years old) and (2) were published in peer-reviewed journals in English between January 2020 and December 2021. Relationships between PA and two MH aspects (i.e., negative and positive psychological responses) among children and youth at different age ranges and those with disabilities or chronic conditions (DCC) were synthesized. Meta-analyses were also performed for eligible studies to determine the pooled effect size.

Results
A total of 58 studies were eventually included for variable categorization, with 32 eligible for meta-analyses. Our synthesis results showed that greater PA participation was strongly related to lower negative psychological responses (i.e., anxiety, depression, stress, insomnia, fatigue, and mental health problems) and higher positive psychological responses (i.e., general well-being and vigor) in children and youth during COVID-19. The pattern and strength of relations between PA and MH outcomes varied across age ranges and health conditions, with preschoolers and those with DCC receiving less attention in the existing research. Meta-analysis results showed that the magnitude of associations of PA with negative (Fisher’s z = − 0.198, p < 0.001) and positive (Fisher’s z = 0.170, p < 0.001) psychological responses among children and youth was weak. These results were linked to age of participants, study quality, and reporting of PA-related information.

Conclusions
PA participation and MH among children and youth deteriorated during the COVID-19 pandemic and were closely associated with each other. For the post-COVID-19 era, additional research on age- and health condition-specific relationships between PA and MH outcomes from a comprehensive perspective is warranted. (Word count: 344 words).
Consensus‐based statements for assessing clinical competency in podiatry‐related work integrated learning
Authors: Causby Ryan S. , Dars Sindhrani , Ho Malia , Walmsley Steven , Munteanu Shannon , Banwell Helen A. 
Published: July 2023

AbstractBackgroundThe training of undergraduate and graduate‐entry podiatry students in Australia and New Zealand includes practical sessions in a simulated and real‐life clinical setting and Work Integrated Learning (WIL) comprising professional clinical placements. Student performance during WIL is evaluated by their Clinical Educators using clinical competency tools. Having a standardised and validated clinical assessment tool for WIL in podiatry would facilitate consistency in assessment, promote standardisation between programs, and ensure that all podiatry students are assessed against a set of criteria over the course of their clinical programs to the point of threshold clinical competency. Therefore, the aim of this study was to develop a series of consensus‐based statements via Delphi technique as the first step towards developing guidelines to direct the assessment of podiatry students during WIL.MethodsThis study used a three‐round modified Delphi consensus method. A panel of 25 stakeholders was sought. Specifically, representation from each of the universities in Australia and New Zealand who provide entry level programs, Clinical Educators, podiatry student representatives, new podiatry graduates and consumers (podiatrists hiring new graduates). The survey for Round 1 aimed for consensus and consisted of five open‐ended questions. Questions one to three asked respondents to nominate what they considered were the important elements that needed to be assessed for podiatry students undertaking WIL for: Clinical performance/skills, Communication and Professional behaviour, Question 4 asked respondents to identify further/other elements of importance, whilst Question 5 asked a) how these elements should be evaluated and b) how should overall competency and ability to progress within the program be determined. Round 2 and 3 aimed to gather agreement and the questions were based on the responses from previous rounds.ResultsTwenty‐five participants agreed to participate, 17 females (68%) and eight males (32%). The panel consisted of 10 podiatry educators (40%), nine Clinical Educators (36%), two student representatives (8%), two new podiatry graduates (8%) and two consumers (8%). From the 25 recruited participants, 21 responded to Round one, 18 to Round two and 17 in Round three. At the conclusion of the Delphi survey, 55 statements had reached consensus or agreement.ConclusionsThis Delphi study is the first of its kind for the podiatry profession to develop consensus‐based statements regarding the assessment of WIL. Fifty‐five statements pertinent to the assessment of WIL were identified. This is an important first step toward the development of a consistent WIL assessment tool which may be applied across entry‐level podiatry programs across Australia and New Zealand.
Allergic reactions to tick saliva components in zebrafish model
Authors: Contreras Marinela , Vaz-Rodrigues Rita , Mazuecos Lorena , Villar Margarita , Artigas-Jerónimo Sara , González-García Almudena , Shilova Nadezhda V. , Bovin Nicolai V. , Díaz-Sánchez Sandra , Ferreras-Colino Elisa , Pacheco Iván , Chmelař Jindřich , Kopáček Petr , Cabezas-Cruz Alejandro , Gortázar Christian , de la Fuente José 
Published: July 2023

Abstract
Background
Alpha-Gal syndrome (AGS) is a tick-borne food allergy caused by IgE antibodies against the glycan galactose-alpha-1,3-galactose (α-Gal) present in glycoproteins and glycolipids from mammalian meat. To advance in the diagnosis and treatment of AGS, further research is needed to unravel the molecular and immune mechanisms underlying this syndrome. The objective of this study is the characterization of tick salivary components and proteins with and without α-Gal modifications involved in modulating human immune response against this carbohydrate.

Methods
Protein and α-Gal content were determined in tick saliva components, and proteins were identified by proteomics analysis of tick saliva fractions. Pathophysiological changes were recorded in the zebrafish (Danio rerio) model after exposure to distinct Ixodes ricinus tick salivary components. Serum samples were collected from zebrafish at day 8 of exposure to determine anti-α-Gal, anti-glycan, and anti-tick saliva protein IgM antibody titers by enzyme-linked immunosorbent assay (ELISA).

Results
Zebrafish treated with tick saliva and saliva protein fractions combined with non-protein fractions demonstrated significantly higher incidence of hemorrhagic type allergic reactions, abnormal behavioral patterns, or mortality when compared to the phosphate-buffered saline (PBS)-treated control group. The main tick salivary proteins identified in these fractions with possible functional implication in AGS were the secreted protein B7P208-salivary antigen p23 and metalloproteases. Anti-α-Gal and anti-tick salivary gland IgM antibody titers were significantly higher in distinct saliva protein fractions and deglycosylated saliva group when compared with PBS-treated controls. Anti-glycan antibodies showed group-related profiles.

Conclusions
Results support the hypothesis that tick salivary biomolecules with and without α-Gal modifications are involved in modulating immune response against this carbohydrate.

Graphical Abstract
Single-cell RNA sequencing analysis of the temporomandibular joint condyle in 3 and 4-month-old human embryos
Authors: Zhu Qianqi , Tan Miaoying , Wang Chengniu , Chen Yufei , Wang Chenfei , Zhang Junqi , Gu Yijun , Guo Yuqi , Han Jianpeng , Li Lei , Jiang Rongrong , Fan Xudong , Xie Huimin , Wang Liang , Gu Zhifeng , Liu Dong , Shi Jianwu , Feng Xingmei 
Published: July 2023

Abstract
Background
The temporomandibular joint (TMJ) is a complex joint consisting of the condyle, the temporal articular surface, and the articular disc. Functions such as mastication, swallowing and articulation are accomplished by the movements of the TMJ. To date, the TMJ has been studied more extensively, but the types of TMJ cells, their differentiation, and their interrelationship during growth and development are still unclear and the study of the TMJ is limited. The aim of this study was to establish a molecular cellular atlas of the human embryonic temporomandibular joint condyle (TMJC) by single-cell RNA sequencing, which will contribute to understanding and solving clinical problems.

Results
Human embryos at 3 and 4 months of age are an important stage of TMJC development. We performed a comprehensive transcriptome analysis of TMJC tissue from human embryos at 3 and 4 months of age using single-cell RNA sequencing. A total of 16,624 cells were captured and the gene expression profiles of 15 cell clusters in human embryonic TMJC were determined, including 14 known cell types and one previously unknown cell type, "transition state cells (TSCs)". Immunofluorescence assays confirmed that TSCs are not the same cell cluster as mesenchymal stem cells (MSCs). Pseudotime trajectory and RNA velocity analysis revealed that MSCs transformed into TSCs, which further differentiated into osteoblasts, hypertrophic chondrocytes and tenocytes. In addition, chondrocytes (CYTL1high + THBS1high) from secondary cartilage were detected only in 4-month-old human embryonic TMJC.

Conclusions
Our study provides an atlas of differentiation stages of human embryonic TMJC tissue cells, which will contribute to an in-depth understanding of the pathophysiology of the TMJC tissue repair process and ultimately help to solve clinical problems.
Animal models of Parkinson’s disease: bridging the gap between disease hallmarks and research questions
Authors: Dovonou Axelle , Bolduc Cyril , Soto Linan Victoria , Gora Charles , Peralta III Modesto R. , Lévesque Martin 
Published: July 2023

AbstractParkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by motor and non-motor symptoms. More than 200 years after its first clinical description, PD remains a serious affliction that affects a growing proportion of the population. Prevailing treatments only alleviate symptoms; there is still neither a cure that targets the neurodegenerative processes nor therapies that modify the course of the disease. Over the past decades, several animal models have been developed to study PD. Although no model precisely recapitulates the pathology, they still provide valuable information that contributes to our understanding of the disease and the limitations of our treatment options. This review comprehensively summarizes the different animal models available for Parkinson’s research, with a focus on those induced by drugs, neurotoxins, pesticides, genetic alterations, α-synuclein inoculation, and viral vector injections. We highlight their characteristics and ability to reproduce PD-like phenotypes. It is essential to realize that the strengths and weaknesses of each model and the induction technique at our disposal are determined by the research question being asked. Our review, therefore, seeks to better aid researchers by ensuring a concrete discernment of classical and novel animal models in PD research.
Using diagnostic feedback to enhance the development of phonetic knowledge of an L2: a CALL design based on the unified competition model and the implementation with the Pinyin Tutor
Authors: Zhang Yanhui , MacWhinney Brian 
Published: July 2023

AbstractSecond language acquisition (SLA) is complex and multidimensional. Using the framework of the unified competition model (UCM), the current study explores how robust learning and testing of Chinese Pinyin are fostered by optimal integration of different kinds of feedback in an intelligent computer-assisted language learning (CALL) environment offered by the Pinyin Tutor at TalkBank. The findings demonstrated that the repeated feedback-embedded training with the Pinyin Tutor significantly boosted the learners’ proficiency in all aspects of Pinyin knowledge for second language (L2) learners of Chinese whose first language (L1) backgrounds were varied and whose initial proficiencies in Chinese were elementary. Furthermore, there was a strong increase in Pinyin knowledge, as evidenced in the delayed posttest administered 3 months after finishing the training sessions. The results further showed that diagnostic feedback led to greater improvement than basic feedback. The significance of the results is attributed to the design of the Pinyin Tutor, which implements principles from psycholinguistic theory as well as corpus data on the speech production by L2 learners. The study sheds fresh light on improving the Pinyin Tutor, and CALL in general, by incorporating up-to-date findings in educational psychology.