bluuebunny/crossref_metadata_2025_split huggingface dataset:
THE LAYER HEIGHT VARIATIONS EFFECT ON TENSILE STRENGTH OF 3D PRINTING PRODUCT PLA MATERIAL BASED
Authors: Cahyati Sally , Furqon Yusuf Al 
Published: January 2023

3D Printing products are produced and used for many purposes like biomedical equipment, mechanical part, and so on. Therefore, mechanical properties are important for 3D Printing products. Layer height as one of the 3D Printing process parameters will be observed to know the effect on product tensile strength and printing time. The research has used ASTM D638 standard specimens from PLA material base with layer height parameter variations between 0.1mm, and 0.3 mm. The specimens are printed by 3D Print Creality Ender 3-Pro, then will be tested by Tensile Machine. The result finds both the printing time and the tensile strength of 3D printing products are affected by the variations in the layer height. The printing time will decrease along with the layer height increasing. For the layer height dimension nearly the nozzle diameter of 0.3 mm, the tensile strength is 10.16 MPa. It is significantly better than the 0.1 mm to 0.25 mm layer height which has a tensile strength range of 7.07 to 8.59 MPa. The condition is because the path internal bond in the 0.3 mm layer height has more homogeneity.
Structural proteins of SARS-CoV-2
Authors: Duvanova O. V. , Chemisova O. S. , Noskov A. K. 
Published: January 2023

The review presents the basic information available in the literature on the structural proteins of SARS-CoV-2 (S;N;E;M). Issues affecting the importance of these proteins in the pathogenesis, adaptation and life cycle of the virus are discussed. Structural multifunctional proteins are biomarkers of increased contagiousness and pathogenicity of SARS-CoV-2, forming its pathogenetic and adaptive potential. The multifunctionality of the structural proteins of the new coronavirus allows it to respond quickly to fluctuations in the conditions of existence through the use of alternative approaches to implement the mechanisms underlying its pathogenetic potential. Currently, the structure, properties, functions and role of structural proteins of SARS-CoV-2 are being actively studied, which is an actual vector of research that allows us to decipher the mechanisms underlying its high contagiousness, pathogenicity, adaptation, and in the future to evaluate possible ways of forming its new variants and develop a strategy and tactics of emergency response when it appears new strains.The prospects of further study of the structure and properties of structural proteins for solving the priority tasks of the present time on the creation of modern domestic vaccines and effective methods of diagnosis, treatment and prevention of a new coronavirus are noted.The authors analyzed scientific publications from various databases of electronic libraries, such as PubMed, e-library, CyberLeninka, etc.
Helping Patients With Chronic Conditions Overcome Challenges of High-Deductible Health Plans: Mixed Methods Study
Authors: Hu Tiffany Yung-Shin , Ali Iman , Heisler Michele , Levy Helen , Fagerlin Angela , Kullgren Jeffrey T 
Published: January 2023

Background
A growing number of Americans are enrolled in high-deductible health plans (HDHPs). Enrollees in HDHPs, particularly those with chronic conditions, face high out-of-pocket costs and often delay or forgo needed care owing to cost. These challenges could be mitigated by the use of cost-conscious strategies when seeking health care, such as discussing costs with providers, saving for medical expenses, and using web-based tools to compare prices, but few HDHP enrollees engage in such cost-conscious strategies. A novel behavioral intervention could enable HDHP enrollees with chronic conditions to adopt these strategies, but it is unknown which intervention features would be most valued and used by this patient population.

Objective
This study aimed to assess preferences among HDHP enrollees with chronic conditions for a novel behavioral intervention that supports the use of cost-conscious strategies when planning for and seeking health care.

Methods
In an exploratory sequential mixed methods study among HDHP enrollees with chronic conditions, we conducted 20 semistructured telephone interviews and then surveyed 432 participants using a national internet survey panel. Participants were adult HDHP enrollees with diabetes, hypertension, coronary artery disease, chronic obstructive pulmonary disease, or asthma. The interviews and survey assessed participants’ health care experiences when using HDHPs and their preferences for the content, modality, and frequency of use of a novel intervention that would support their use of cost-conscious strategies when seeking health care.

Results
Approximately half (11/20, 55%) of the interview participants reported barriers to using cost-conscious strategies. These included not knowing where to find information and worrying that the use of cost-conscious strategies would be very time consuming. Most (18/20, 90%) interviewees who had discussed costs with providers, saved for medical expenses, or used web-based price comparison tools found these strategies to be helpful for managing their health care costs. Most (17/20, 85%) interviewees expressed interest in an intervention delivered through a website or phone app that would help them compare prices for services at different locations. Survey participants were most interested in learning to compare prices and quality, followed by discussing costs with their providers and putting aside money for care, through a website-based or email-based intervention that they would use a few times a year.

Conclusions
Regular use of cost-conscious strategies could mitigate financial barriers faced by HDHP enrollees with chronic conditions. Interventions to encourage the use of cost-conscious strategies should be delivered through a web-based modality and focus on helping these patients in navigating their HDHPs to better manage their out-of-pocket spending.
Facilitators and Barriers of Tai Chi Practice in Community-Dwelling Older Adults: Qualitative Study
Authors: Du Yan , Roberts Penny , Liu Wei 
Published: January 2023

Background
Numerous studies have documented the beneficial effects of Tai Chi on a variety of health outcomes, especially in older adults. However, only few studies have examined how to improve the practice and adherence of this Asian-originated exercise among older adults in Western countries.

Objective
This study aimed to identify facilitators and barriers to Tai Chi practice and adherence in community-dwelling older adults.

Methods
This study analyzed the qualitative data collected from 13 participants (mean age 62.0, SD 10.3) at the end of a 15-week randomized controlled trial conducted at a day activity senior center. Semistructured interviews were conducted, recorded, and transcribed; and the data were analyzed using inductive thematic analysis.

Results
Four themes emerged: perceived benefit, threats, facilitators, and barriers. Perceived threats (eg, aging and side effects of medications) and perceived benefits of Tai Chi (eg, balance) inspired participants’ engagement in Tai Chi exercise. On the other hand, barriers to Tai Chi practice and adherence included instructor’s teaching style, the complexity of Tai Chi postures and movements, and existing health conditions (eg, hip problems). In essence, factors like Tai Chi class availability, family and peer support, as well as practicing Tai Chi with music may facilitate Tai Chi exercise adherence.

Conclusions
The study findings could provide valuable information to health professionals, such as nurses and physical therapists, in developing and implementing effective Tai Chi programs in care plans. Considering health conditions, tailoring Tai Chi exercise instruction styles, encouraging social and peer support, and incorporating music may promote Tai Chi practice and adherence.
In-silico study of compounds of Curcuma xanthorriza against enzyme tyrosinase sac and α-MSH
Authors: Mustarichie Resmi , Ramdhani Danni 
Published: January 2023

Previous report determined that curcumin, demetoxycurcumin and xanthorrhizol are an active compounds contained in Curcuma xanthorrhiza which have activity in inhibiting the tyrosinase enzyme and α-melanocyte stimulating hormone (α-MSH ) in vitro. This study aimed to determine and visualize the interaction of the three compounds with the tyrosinase enzyme and α-MSH in order to find their possibility for skin whitening. The experiment carried out using Auto Dock Vina program .The results of docking simulations showed that the three compounds can interact spontaneously with the tyrosinase enzyme and α-MSH. On the tyrosinase enzyme, xanthorrhizol interact most easily through the formation of hydrogen bonds with Asn205. On the α-MSH, demethoxycurcumin interact most easily through the formation of two hydrogen bonds with His3 and Arg5. With the inhibitory effect on the enzyme tyrosinase and α-melanocyte stimulating hormone (α-MSH) means preventing the formation of skin coloring pigment melanin, indicating that the three compounds studied can be applied as skin whitening agents.
Development and Validation of RP-HPLC Method for Oral Printed Films of Ketorolac Tromethamine
Authors: Dule Priya , Kilor Vaishali 
Published: January 2023

For the analysis of Ketorolac Tromethamine in Oral film formulation, a simple, precise, and accurate method was developed and validated. On a Kromosil C18 column (150 cm 4.6 mm 5), an isocratic HPLC analysis was performed. The chemical was isolated using a solution of A 55:45 V/V methanol and ammonium dihydrogen phosphate buffer with a pH of 3.0 was used. Adjusted with 1.5 mL/min flow of O-phosphoric acid as the mobile phase UV detection was carried out. Photo diode array detection was used at 314 nm. The retention time was discovered to be 6.08 minutes. The system suitability criteria, such as theoretical plate count, tailing, and percentage, should be kept to a minimum. The RSD between six standard injections was within the acceptable range. The procedure was tested and found to be valid. According to the ICH guidelines over the concentration range of 50-150 gm/L, calibrations were linear. The correlation coefficient (r) of 0.999 indicates this. The method's resilience was tested by systematically changing the chromatographic settings. The approach described may be used for routine quantitative analysis.
Effects of Various Emulsifying Agent and Permeability Enhancer on Percutaneous Absorption of Novel Microemulsion-Based Cream
Authors: Borasi Priyanka , Bundela Ragini , Chaturvedi Mohit , Jain Sourabh , Shukla Karunakar 
Published: January 2023

Terbinafine hydrochloride is an antifungal drug used in the treatment of fungal infections. The oral use of terbinafine hydrochloride is not recommended as it has many potential side effects and undergoes hepatic first pass metabolism. Topical route of application has a great potential as an effective and safe way to administer drug for its antifungal in effect. The concentration of surfactant and permeation enhancer significantly affects the critical parameters of cream formulation like flux, cumulative amount released at 12 hours and enhancement ratio. In vitro permeation study across rat epidermal membrane showed that menthol enhanced the transdermal absorption of drug from cream formulation. The topical cream formulation developed in this study holds the promise for the further in vivo studies. The aim of the present work under investigation is to check the effects of emulsifying agents (Cremophor RH40, Tween 60) and permeation enhancers (l-Menthol) on cream. Developing a formulation that is safe and can deliver the drug locally in an effective concentration for its effect. The development of topical antifungal drug delivery systems designed to have localized effects appears to be very advisable and beneficial over conventional routes of provides the drug administration. However, due to the relative impermeability of the stratum corneum, which principal resistance to percutaneous absorption, extensive studies are generally necessary in order to optimize both the release of the drug from the topical vehicle and skin permeation further, A topical formulation must be both physically and chemically stable, this require numerous excipients. Aesthetically pleasing, in addition to being properties, hence they play emulsifying agents and permeation enhancers have major influence on these important role.
Keywords: Emulsifying agents, Permeation enhancers, Stratum corneum, Antifungal, Topical cream
Strategi pemasaran melalui media sosial dalam mempertahankan tingkat hunian hotel bali hai tide beach resort selama masa pandemi (covid – 19)
Authors: Pastika I Putu Dede Adi 
Published: January 2023

Tujuan penelitian ini untuk mendeskripsikan implikasi COVID – 19 terhadap tingkat hunian hotel di Bali Hai Tide Beach Resort, dan untuk mengetahui strategi pemasaran melalui media sosial dalam meningkatkan hunian hotel di Bali Hai Tide Beach Resort selama masa Pandemi COVID – 19 ini. Dapat disimpulkan bahwa saat ini dampak dari penyebaran corona virus atau COVID – 19 ini sangat berpengaruh signifikan terhadap pendapatan hotel dimana tingkat hunian kamar terlihat semua kamar yang tidak ada pengunjungnya dan hotel tutup. Dengan terjadinya pandemic COVID – 19 ini merubah segala hal termasuk budaya masyarakat. Masyarakat saat ini lebih memilih berinteraksi melalui media sosial karena beberapa himbauan dari pemerintah yang melarang berinteraksi secara langsung. Bali Hai Tide Beach Resort memanfaatkan tren tersebut dengan melakukan promosi menggunakan digital marketing, salah satunya adalah melalui media sosial. Hal ini secara tidak langsung dapat menunjang strategi pemasaran yang dilakukan oleh hotel. Hal ini juga diperkuat dengan pernyataan staf sales marketing yang menyebutkan bahwa disaat ini, aktifitas promosi yang dapat dioptimalkan hanya berupa promosi melalui media sosial.

The purpose of this study is to: describe the implications of COVID-19 on hotel occupancy rates at Bali Hai Tide Beach Resort, and to find out marketing strategies through social media in increasing hotel occupancy at Bali Hai Tide Beach Resort during the COVID-19 pandemic. It can be concluded that currently the impact of the spread of the corona virus or COVID-19 has a significant effect on hotel revenues where the room occupancy rate is seen in all rooms that have no visitors and the hotel is closed. With the COVID-19 pandemic, everything has changed, including the culture of society. People currently prefer to interact through social media because of several appeals from the government that prohibit direct interaction. Bali Hai Tide Beach Resort takes advantage of this trend by promoting using digital marketing, one of which is through social media. This can indirectly support the marketing strategy carried out by the hotel. This is also reinforced by the statement of the sales marketing staff who stated that currently, promotional activities that can be optimized are only in the form of promotions through social media.
Kualitas tortilla gluten free berbahan dasar oat
Authors: Muzaki Alvian 
Published: January 2023

Tortilla adalah salah satu jenis flatbread yang terbuat dari tepung terigu, baking powder, garam, oil dan air hangat. Tujuan dari penelitian ini adalah untuk mengetahui kualitas tortilla gluten free dengan menggunakan oat. Metode penelitian yang diterapkan pada penelitian ini adalah metode penelitian kualitatif, kuantitatif dengan jenis penelitian eksperimental dan teknik pengumpulan data yang dilakukan secara observasi juga kuesioner. Dalam menentukan kualitas dari tortilla gluten free berbahan dasar oat dinilai dengan menggunakan teknik uji organoleptik yang diujikan kepada 30 responden yang mendapatkan hasil penelitian bahwa tortilla gluten free berbahan dasar 100% oat (P1) memiliki kualitas keunggulan dibagian tekstur yang renyah. Dalam aspek rasa dan aroma, tortilla berbahan dasar oat atau tepung terigu memiliki keunggulannya masing masing dari setiap responden.

Tortillas are a type of flatbread made from wheat flour, baking powder, salt, oil and warm water. The goal of the study was to find out the quality of gluten-free tortillas using oats. The research methods applied to this study are qualitative, quantitative research methods with experimental types of research and data collection techniques conducted by observation as well as questionnaires. In determining the quality of the oat-based gluten free tortillas assessed using organoleptic test techniques tested to 30 respondents who got the results of research that gluten free tortillas made from 100% oats (P1) have a quality of excellence in the crisp texture. In terms of taste and aroma, oat-based tortillas or wheat flour have their own advantages from each respondent.
ANALISIS TERHADAP KONSEPTUALISASI OMNIBUS LAW SEBAGAI UPAYA PENYELESAIAN MASALAH REGULASI HUKUM DI INDONESIA BERDASARKAN UNDANG-UNDANG REPUBLIK INDONESIA NOMOR 15 TAHUN 2019 TENTANG PEMBENTUKAN PERATURAN PERUNDANG-UNDANGAN
Authors: Pando Pando , Kosariza Kosariza 
Published: January 2023

Tujuan dari penelitian ini adalah: 1) Untuk mengetahui dan menganalisis konseptualisasi Omnibus Law sebagai upaya penyelesaian masalah regulasi hukum di Indonesia berdasarkan Undang-Undang Republik Indonesia Nomor 15 Tahun 2019 Tentang Pembentukan Peraturan Perundang-Undangan dan 2) Untuk mengetahui dan menganalisis ketepatan konsep Omnibus Law sebagai upaya penyelesaian masalah regulasi hukum di Indonesia berdasarkan Undang-Undang Republik Indonesia Nomor 15 Tahun 2019 Tentang Pembentukan Peraturan Perundang-Undangan. Penelitian ini adalah bersifat yuridis normative dengan pendekatan Perundang-Undangan (Statuta approach). Analisis data dalam penelitian ini menggunakan analisis deskriptif. Hasil dari penelitian ini adalah: 1) Konseptualisasi Omnibus Law sebagai upaya penyelesaian masalah regulasi hukum di Indonesia berdasarkan Undang-Undang Republik Indonesia Nomor 15 Tahun 2019 Tentang Pembentukan Peraturan Perundang-Undangan adalah suatu konsep hukum yang menitikberatkan pada penyederhanaan jumlah regulasi karena sifatnya yang merevisi dan mencabut banyak Undang-Undang sekaligus. Akan tetapi, dalam penerapannya konseptualisasi Omnibus Law ini membutuhkan prinsip partisipasi, transparansi, dan akuntabilitas. Sehingga Undang-Undang Nomor 15 Tahun 2019 tentang Pembentukan Peraturan Perundang-Undangan perlu direvisi kembali. 2) Konsep Omnibus Law sebagai upaya penyelesaian masalah regulasi hukum di Indonesia belum diatur secara jelas dalam Undang-Undang Nomor 15 Tahun 2019 tentang Pembentukan Peraturan Perundang-Undangan, maka konsep omnibus law bisa mengarah sebagai Undang-Undang Payung karena mengatur secara menyeluruh dan kemudian mempunyai kekuatan terhadap aturan yang lain. Akan tetapi, konsep Omnibus Law ini dianggap kurang tepat dan menimbulkan polemic karena adanya anggapan bahwa landasan sosiologis dalam pembentukan konsep Omnibus Law terkesan dibuat-buat dan tidak menggambarkan kebutuhan masyarakat yang sebenarnya.

Kata Kunci : Konseptualisasi, Omnibus Law, Regulasi Hukum
Regrowth of Dwarf Elephant Grass (Pennisetum purpureum cv. Mott) Treated with Nitrogen Fertilizer in its Initial Development
Authors: Wahyu Baso , Mustaring  , Basri Moh. 
Published: January 2023

Tujuan penelitian ini untuk mengkaji pengaruh perlakuan awal pemupukan nitrogen terhadap pertumbuhan kembali rumput Pennisetum purpureum cv. Mott pada penelitian terdahulu pada tahun 2018 setelah tanam dan mengalami 5 kali pemangkasan berulang. Penelitian ini dilaksanakan selama dua bulan, di Kebun Koleksi dan Pengembangan Tanaman Hijauan Makanan Ternak milik CV. Sandtya Saryamkusuma, di Desa Loru Kecamatan Sigi Biromaru, Kabupaten Sigi, Sulawesi Tengah. Perlakuan pemberian pupuk nitrogen dengan dosis berbeda yakni: 0; 50; 100; dan 150 kg N/ha, setara berturut-turut 0 kg/ha; 10,87 kg/ha; 21,74 kg/ha dan 32,61 kg/ha dengan 5 kali ulangan, sehingga diperoleh 20 unit percobaan yang diatur dengan menggunakan Rancangan Acak Kelompok (RAK). Variabel yang diamati meliputi; tinggi tanaman, panjang helaian daun, lebar helaian daun, panjang pelepah daun dan jumlah anakan. Data yang diperoleh dianalisis menggunakan ANOVA (Analysis of Variance) dengan program STAT-27. Hasil analisis keragaman menunjukkan perlakuan tidak berpengaruh nyata (p>0,05) terhadap masing-masing parameter. Disimpulkan bahwa; i) sudah tidak ada residu pupuk dari pemupukan pada penelitian terdahulu atau perbedaan residu yang ada antar perlakuan sudah tidak mampu memicu perbedaan pertumbuhan kembali tanaman percobaan; dan ii) pemupukan nitrogen diperlukan untuk mengembalikan pertumbuhan yang lebih baik dari rumput gajah mini pada kondisi lokasi penelitian ini.
Penghentian Penyidikan Kasus Kecelakaan Lalu Lintas di Polres Boyolali
Authors: Elsa Ananda Putri  , Suciyani  
Published: January 2023

Traffic accidents are caused by human error and negligence. Traffic accidents that can harm property or the lives of others caused by human factors, vehicles, roads and the environment as well as weather factors. Traffic accidents that result in the death of the victim must be subject to legal proceedings according to applicable law starting from an investigation by the police, prosecution by the prosecutor's office and the court by the court to obtain a decision, but in practice investigators can stop the legal process. This research is classified as a qualitative research, namely by processing primary data obtained by the parties concerned with cases of traffic accidents that cause the loss of other people's lives, as well as data that are considered important which are generated by direct interviews at the research location. The conclusion in this study is that the process of stopping the investigation carried out by the police at the Boyolali Police can reflect a sense of justice between the suspect's family and the victim's family which was carried out with family deliberation so that they were given the opportunity to express their opinions and desire to find good solutions to the problems faced by both parties. party. Islam places peace/islah as an alternative in resolving criminal cases, as long as the case has not yet reached the hands of the judge. This principle can be realized by resolving criminal cases with peace at the level of investigation.