bluuebunny/crossref_metadata_2025_split huggingface dataset:
A low psoas muscle index was associated with a poorer overall survival in patients who underwent percutaneous nephrostomy
Authors: Shimokihara Kota , Kawahara Takashi , Makiyama Kazuhide , Uemura Hiroji 
Published: June 2023

Abstract
Introduction
Malignant ureteral obstruction (MUO) caused by urological, gynecological, and gastrointestinal cancer requires a nephrostomy or ureteral stenting to preserve the renal function and prevent pain and urinary tract infections. Recent investigations have revealed the importance of sarcopenia as a poor prognostic factor in various solid malignancies. This study investigated the importance of sarcopenia as a prognostic factor for MUO patients who have undergone nephrostomy.
Materials & Methods
A total of 89 percutaneous nephrostomies were created from July 2008 to March 2016 in our institutions. Fifty-seven of these patients had MUO. The psoas muscle volume was calculated at the L3 level using axial computed tomography images obtained prior to nephrostomy. The psoas muscle index (PMI) was calculated using the following formula: (right side psoas muscle area at the level of L3 [mm2]) / (body height [m])2.
Results
In these 57 patients, 41 cases (71.9%) were male, and 16 (28.1%) were female. The median (mean ± SD) age was 70 (69.0 ± 9.6) years old in males and 68 (66 ± 13.5) years old in females. Primary malignant diseases in MUO were urological cancers in 29 cases (50.9%), gastrointestinal cancers in 19 cases (33.3%), and gynecological cancers in 6 cases (10.5%). There were no marked differences in the OS among malignant diseases. A low PMI was associated with a poor overall survival in male MUO patients.
Conclusion
The patients who underwent percutaneous nephrostomy with sarcopenia showed a poor overall survival.
Application of the combination of CBL teaching method and SEGUE Framework to improve the doctor-patient communication skills of resident physicians in otolaryngology Department
Authors: Zeng Nan , Lu Hui , Li Shuo , Yang Qiong , Pan Hongguang , Yan Shang 
Published: June 2023

Abstract
Objective
To explore the feasibility and effectiveness of applying CBL teaching method and SEGUE Framework in the doctor-patient communication skills of resident physicians in the department of otolaryngology.
Methods
The score changes of doctor-patient communication skills of 120 resident physicians before and after using CBL combined SEGUE Framework teaching method were analyzed retrospectively, and the effects of gender, age, grade, educational background and marital status on SEGUE score were analyzed.
Results
Through the combined application of CBL teaching method and SEGUE Framework, the SEGUE score of 120 resident physicians was significantly improved. There was no significant difference in SEGUE score among different sex and marital status of resident physicians. SEGUE score is positively correlated with age; Different grades and educational backgrounds have significant effects on SEGUE score.
Conclusion
The combination of CBL teaching method and SEGUE Framework is feasible and effective in the teaching of doctor-patient communication skills of resident physicians in the department of otolaryngology, and worthy of popularization and application in other medical specialties.
Diffusion-induced stresses in crystals: Implications for timescales of mountain building
Authors: Hess Benjamin , Ague Jay 
Published: June 2023

Abstract
Intracrystalline chemical diffusion offers valuable insights into the durations of metamorphic and igneous processes. However, it can yield timescale estimates for orogenic events that are considerably shorter than those obtained via isotopic geochronology. One potential explanation for the discrepancy is that diffusion of species with different molar volumes may generate intracrystalline, compositional stresses that limit diffusional relaxation. Here, we show that compositional stress can increase the interpreted timescales of lithospheric processes by an order of magnitude or more by investigating a well-characterized garnet from the Barrovian sillimanite zone, Scotland. The garnet records sharp micrometer-scale variations in calcium and iron contents that standard diffusion treatments predict should relax in 1–10 kyr during peak thermal metamorphism. Conversely, compositional stress allows these features to persist for >100 kyr timescales, consistent with independent estimates from strontium-in-apatite tracer diffusion chronometry. Therefore, accounting for compositional stress can dramatically alter the interpretation of fundamental lithospheric processes.
Turnover behavior and intention among dentists in comparison with clinicians: A Cross- Sectional Study in China
Authors: Shi Keying , Wang Yong , Sun Zhe , Zhao Jing , Xiang Fangyue , Chen Zhi , Sun Wenjing , Zheng Yuanna 
Published: June 2023

Abstract
Background: Retention of doctors is a global challenge and doctors working in different departments may face different problems. The study aimed to explore the turnover behavior and intention and correlated factors among Chinese dentists compared with clinicians.
Methods: A cross-sectional study was conducted online in 5 regions of China from March 12th to April 12th, 2020. The questionnaire included 3 parts, socio-demographic characteristics, turnover behavior and intention, and concern about work-related factors. Chi-square test and/or Wilcoxon Mann-Whitney test were applied for comparison, and binary logistic regression was used for finding the factors.
Results: 2428 eligible questionnaire were received, including 1954 dentists and 474 clinicians. Rate of turnover behavior and intention was 2.87% and 51.79% among dentists, significantly lower than that among clinicians (6.96% and 71.20%, P<0.000). Compared with clinicians, dentists had significantly lower concern about workload, salary, and strained doctor-patient relationship (P<0.01), but more concern about occupational exposure (P<0.000). Educational level was a common factor of clinicians’ and dentists’ turnover behavior, while concern about salary was only for dentists. Age, concern about workload and doctor-patient relationship was common factors of clinicians’ and dentists’ turnover intention. Gender and annual household income were also correlated with dentists’ turnover intention.
Conclusions: Low turnover rate but high turnover intention rate was the current status of Chinese doctors’ employment. Turnover behavior and intention were more optimistic among dentists than clinicians. Common factors correlated with turnover behavior and intention existed among dentists and clinicians, while correlations between concern about salary, gender, annual household income and turnover only existed among dentists.
Mersilene tape versus conventional suture for preventing preterm birth in patients undergoing transvaginal cervical cerclage ： a systematic review and meta-analysis
Authors: feng Juntao , Wei Shisi , Pang Lihong 
Published: June 2023

Abstract
OBJECTIVE
This study aimed to evaluate the effectiveness of Mersilene tape and other suture types used in cervical cerclage procedures in prolonging singleton gestation in women at high risk of pregnancy loss due to a short cervix. The study also aimed to compare the characteristics, complications, pregnancy outcomes, and neonatal outcomes associated with the use of Mersilene tape and other suture types.
METHODS
A systematic review was conducted to identify relevant studies comparing different suture types in cervical cerclage procedures. The primary outcome of interest was preterm birth (PTB) rate. Statistical analyses were performed to determine the relationship between suture type and various outcomes.
RESULTS
A total of five studies involving 2325 participants were included in the meta-analysis. The pooled analysis indicated no significant association between suture type and PTB at less than 37 weeks of gestation (RR: 1.02, 95% CI: 0.65–1.60, p < 0.01, I2 = 74%). However, women who received Mersilene tape had a higher risk of PTB at 34–37 weeks (RR: 2.62, 95% CI: 1.57–4.37, p = 0.69, I2 = 0%), but a lower risk of PTB at less than 34 weeks (RR: 0.43, 95% CI: 0.28–0.66, p = 0.66, I2 = 46%). No statistically significant differences were observed for PTB at less than 28 weeks (RR: 1, 95% CI: 0.65–1.53, p = 0.70, I2 = 0%) and less than 24 weeks (RR: 0.86, 95% CI: 0.60–1.23, p = 0.33, I2 = 0%). Additionally, no significant differences were found in the use of Mersilene tape compared to other suture types regarding chorioamnionitis, neonatal intensive care unit (NICU) admission and neonatal death.
CONCLUSION
The findings suggest that Mersilene tape is not superior to other suture materials in terms of cerclage efficacy for high-risk women with a short cervix. However, further studies are required to validate these results and assess other outcomes, such as surgical complications and neonatal outcomes.
Bioinformatics-based screening of sepsis biomarkers
Authors: Guo Wentao , Chen Wenhao , Li Yang , Chen Muhu 
Published: June 2023

Abstract
Purpose
RNA-seq sequencing and bioinformatics methods were combined to identify differentially expressed genes,and Investigated new biomarkers for sepsis diagnosis and treatment.
Methods
Blood samples from 30 patients with sepsis, 10 normal volunteers, and 15 patients with systemic inflammatory response syndrome (systemic inflammatory response group) were collected in the Affiliated Hospital of Southwest Medical University for RNA-seq sequencing(TRN:ChiCTR1900021261,Date:2019.02.04).After differentiating the data, the Venn plot intersection, GO enrichment analysis, and protein interaction analysis were performed.Using the public dataset, a survival curve was constructed for the differential genes. The expression of different groups was verified as statistically significant, and then the ROC curve was constructed with sequencing data.Finally, with the help of single-cell transcriptome sequencing, the localization cell line of the core gene was identified.
Results
Comparing with the normal group, sepsis serum samples were screened for 365 differentially expressed genes: 85 were downregulated and 280 were upregulated. Compared with the systemic inflammatory response group, in the serum samples of patients with sepsis, 484 differential genes were identified.By intersection, 98 differentially expressed genes were identified, of which 184 were down-regulated and 300 were up-regulated. Among these differential genes GO function is enriched in specific granules, tertiary granules and specific granule cavities. CEBPE, IL1R2, CYSTM1, S100A9, FCER1A, MCEMP1, NELL2, SERPINB10 were found in the center of the protein interaction network analysis.Based on RNA-sequencing data, CEBPE was highly expressed in the sepsis group and NELL2 was low in the group.The survival curve showed that the lower the CEBPE expression in patients with sepsis, the higher the NELL2 expression and the higher the survival rate. Based on the ROC curves, CEBPE had an AUC of 0.920 (normal), 0.882 (systemic inflammatory response group), while NELL2 had an AUC of 0.960(normal), 0.844 (systemic inflammatory response group).In single-cell sequencing, CEBPE was mainly found in macrophage cells and NELL2 was found in T cells.
Conclusion
CEBPE expression in macrophages is positively correlated with sepsis mortality. NELL2 expression in T cell lines is positively correlated with survival rates in sepsis patients.Both have good diagnostic value, or they can be used as new research targets.
Association between dietary protein intake and depression in American adults with metabolic syndrome
Authors: Gu Xue , Shen Xia , Liu Yuan-Yuan , Chu Jiang-Hui , Jiang Lei 
Published: June 2023

Abstract
Background
There is currently intense interest in the effects of macronutrients on mental disorders. The purpose of the study was to analyze the relationship between depression and protein intake in people with metabolic syndrome.
Methods
The study analyzed data on 7922 individuals with metabolic syndrome that were derived from the National Health and Nutrition Examination Survey (NHANES)1999–2018. To test whether the investigated variables differed significantly, variance and the chi-squared test were used to analyze dietary protein intake among groups. Variables with significant differences were selected for multiple logistic regression analysis to further explore the associations between PHQ-9 defined depressive symptoms and protein. Smoothed curve fitting was employed to determine whether if there was a nonlinear correlation between the two.
Results
As protein eaten increased, the number of participants suffering from depression decreased. After adjusting for confounding variables (eGFR, cancer, thyroid disease, total energy, carbohydrate, fiber, calcium, caffeine intake, magnesium, and general information), multivariate logistic regression analysis indicated that dietary protein may serve as a protective factor for depression. Moreover, a negative nonlinear association between depression and dietary protein was found.
Conclusion
These findings indicate that for individuals with metabolic syndrome dietary protein is relevant to depression.
Estimating the Stage-Discharge Relationship at the Confluence of Ungauged Streams: A Hydrological Modeling Approach
Authors: Saha Probal 
Published: June 2023

Abstract
Understanding flow patterns and developing a stage-discharge relationship is essential for effectively managing and protecting water resources in watersheds. Evidence of streambank erosion at confluences due to high peak flows further highlights the urgency of implementing sustainable management strategies. However, the unavailability of discharge data for sub-watersheds necessitates the use of modeling techniques. This study employed a three-layered Hydrological model VIC to estimate the stage-discharge relationship and analyze flow dynamics. Beaver Creek, a tributary of the Clinch River, and Cox Creek, situated in Knox County, Tennessee, experience seasonal flow fluctuations and sedimentation, which pose significant challenges to stream sustainability. To validate the VIC model, downstream USGS stations were selected to compare model output flow. The VIC model incorporated vegetation, soil, and climate inputs and was calibrated using the efficient Shuffled Complex Evolution Algorithm. The final model outputs demonstrated high performance, with a Nash Sutcliffe efficiency of 0.90 and a linear correlation exceeding 0.87 compared to the USGS downstream stations. The daily fluxes accurately captured flow peaks, demonstrating the model's efficacy. Additionally, the derived stage-discharge relationship provided a power equation with a correlation of 0.76, facilitating further research and analysis. The outcomes of this study hold significant implications for future hydrodynamic modeling efforts, allowing for the observation of flood inundation and wall shear stress at the confluence of Beaver-Cox Creeks.
Ecotype maintenance in Callicarpa subpubescens via local environmental adaptation amidst frequent hybridization and low pre- and post-mating barriers
Authors: Setsuko Suzuki , Sugai Kyoko , Tamaki Ichiro , Hayama Kayo , Kato Hidetoshi 
Published: June 2023

Abstract

Adaptive radiations frequently occur on oceanic islands, but the mechanisms behind the maintenance of species and ecotypes after such radiations remain poorly understood, especially regarding potential gene flow among sympatric congeners. Callicarpa subpubescens is endemic to the oceanic Ogasawara Islands, and it has been suggested that multiple ecotypes exist within the southern part of this group, the Hahajima Islands, each associated with a unique localized habitat. Here, we determined the habitat characteristics of each ecotype and the degree of pre- and post-mating isolation by investigating flowering time overlap cross compatibility, and gene flow among ecotypes using an EST-SSR marker analysis of adult trees and naturally pollinated seeds. Our study confirmed the presence of four distinct ecotypes on the Hahajima Islands, with one likely arising from hybridization. Each ecotype was confined to specific island habitats, and distinct leaf morphologies and plant heights suggested local adaptation. However, overlapping flowering times and successful artificial cross pollination indicated little pre- and post-mating isolation. Hybridization rates in adult trees and naturally pollinated seeds were 37.2% and 26.4%, respectively, and most hybrids were backcrosses with few first- or second-generation hybrids. The hybridization rates of each ecotype and paternal correlation indicated that the flowering synchrony and close spatial distribution of ecotypes contributed to hybridization among ecotypes. Overall, C. subpubescens likely maintains four distinct ecotypes in spite of frequent hybridization probably due to selection pressures that result in reversion to the original ecotype via backcrossing, since this is well-adapted to the local environment.
Compressed Domain Human Fall Detection using Deep Features
Authors: Darvish Mahta , Mansouri Azadeh 
Published: June 2023

Abstract
Falling is one of the most dangerous events that can happen to an adult and can lead to chronic injuries. These damages and adverse effects of falling can be reduced with quick diagnosis and treatment. So far, two general approaches have been introduced for fall detection: sensor-and camera-based which the latter is our approach in this work. After a camera has acquired environmental data, we do some processing on the data to extract the necessary features. Following this, it is the turn of a classifier to tell a falling input from a non-falling one. In this thesis, in addition to reporting the results in the raw mode of the samples in the used datasets, we also present the results in the compressed mode because of the lower complexity and greater applicability of data in compressed form.
Fine-Tuning Buffalo-Veal Meat Slices: The Impact of Particle Size, Fat Content, and Tumbling Time and their Interplay Through Principal Component Analysis
Authors: Singh Pradeep Kumar , Jairath Gauri , Yadav Sanjay , Pathera Ashok Kumar , Ahlawat Satyavir Singh , Sharma Diwakar Prakash 
Published: June 2023

Abstract
Buffalo veal can contribute to the food sustainability to a great extent, but has restricted palatability due to poor marbling at young age. Thus, with an objective to explore the potential of buffalo veal to develop ready-to-eat processed product as an alternative to that prepared from spent animals, especially in India, the study was planned to optimize the particle size, fat level and tumbling time to develop ground meat slices. The objective of particle size and fat level optimization was to improve the meat feel and that of tumbling was to improve binding without affecting the particle size. The product was compared for different quality attributes and interplay of different variables were analyzed through principal component analysis (PCA). The results revealed significantly (P≤0.05) higher ES, WHC, cooking yield, lower dimensional changes, improved slice-ability and fold test were observed in the products developed with 3 mm particle size, 10 per cent fat and 1 hour tumbling time. PCA revealed the association of fat with higher TBA values, dimensional changes (diameter and height) and fat level in the product. The textural parameters were more favorable with smaller particle size and 10% fat level. The study revealed the close association of tumbling with the most of the processing and quality attributes. However, the instrumental color was at par, irrespective of variables except b* value in 10% fat level. The study concluded that buffalo veal slices of improved quality could be prepared at 3mm particle size,10 % fat level and 1 hour tumbling time.
LPCAT1-mediated membrane phospholipid remodeling promotes ferroptosis evasion and tumor growth
Authors: Li Jun , Li Ziwen , Hu Yameng , Zheng Haiqing , Li Man , Feng Rongni , Yang Meisongzhu , Li Xincheng , Zhang Shuxia , Tang Miaoling , xu yingru , Yu Ruyuan , Chen Suwen , Qian Wanying , liao Xinyi , Zhang Qiliang , Li Bo , Song Libing 
Published: June 2023

Abstract

The mechanisms underlying how cells dynamically remodel membrane phospholipids to prevent phospholipid peroxidation-induced membrane damage and evade ferroptosis, which maintains the physiological function of cellular processes and cell survival, remain unclear. Herein, we reported that lysophosphatidylcholine acyltransferase 1 (LPCAT1) played a critical role in ferroptosis resistance by increasing membrane phospholipid saturation via the Land’s cycle, consequently reducing membrane levels of polyunsaturated fatty acids, protecting cells from phospholipid peroxidation-induced membrane damage, and inhibiting ferroptosis. Furthermore, we found that tumor cells that were initially unable to colonize the subcutis formed large tumor nodules after latency was closely associated with the upregulation of LPCAT1 expression and the emergence of a ferroptosis-resistant state. Combining LPCAT1 inhibition with a ferroptosis inducer synergistically induced ferroptosis and suppressed tumor growth. Therefore, our results unveil a plausible role for LPCAT1 in ferroptosis evasion and may represent a new target for clinical intervention in human cancer.
Utility of fractional excretion of magnesium in diagnosing renal magnesium wasting in pediatric nephrology practice
Authors: Awazu Midori , Matsumura Kazuya 
Published: June 2023

Abstract

Background
Renal magnesium (Mg) wasting is associated with tubulointerstitial fibrosis in adults. Fractional excretion of magnesium (FEMg) is commonly used in diagnosing Mg wasting, but it can be affected by serum magnesium (SMg) and creatinine concentration (SCr). We investigated the utility of FEMg in diagnosing Mg wasting combined with SMg, eGFR (estimated glomerular filtration rate), and urine Mg-to-creatinine ratio (Mg/Cr) in pediatric nephrology practice.
Methods
One hundred and nineteen patients (59 males and 60 females, median 15 years) seen in our pediatric clinic were investigated for FEMg, SMg, eGFR, and urine Mg/Cr. Normal eGFR was defined as ≥ 90 ml/min/1.73 m2 or for infants SCr < CKD stage 2. Urine Mg/Cr was compared with age-specific reference values.
Results
Sixteen of all patients (13%) had hypomagnesemia (1.2–1.7 mg/dL) and all had FEMg >2% (mean ± SD: 9.5 ± 11.7%). Only 4 patients had elevated urine Mg/Cr. Of normomagnesemic patients with normal eGFR, 29% (19/65) had FEMg >4% (5.5 ± 1.1%). Among these 19 patients, 68% (13) had elevated urine Mg/Cr. ROC curve analysis showed that a cut-off value for FEMg 4.1% yielded 93% sensitivity and 90% specificity for elevated urine Mg/Cr (AUC = 0.93). In normomagnesemic patients with low eGFR, 79% (30/38) had FEMg >4%, but only 20% of them (6/30) had elevated urine Mg/Cr. Overall, patients with hypomagnesemia and those with elevated urine Mg/Cr were diagnosed as Mg wasting (36/119, 30%).
Conclusions
For the diagnosis of Mg wasting, FEMg should be used in combination with SMg, eGFR, and urine Mg/Cr. Mg wasting is not uncommon in pediatric nephrology practice.