bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inequality on the frontline: A multi-country study on gender differences in mental health among healthcare workers during the COVID-19 pandemic
Authors: Czepiel Diana , McCormack Clare , Silva Andréa Tenório Correia da , Seblova Dominika , Moro Maria Francesca , Restrepo-Henao Alexandra , Alnasser Lubna , Alvarado Ruben , Asaoka Hiroki , Ayinde Olatunde , Balalian Arin , Ballester Dinarte , Barathie Josleen A. I. , Basagoitia Armando , Basic Djordje , Burrone María Soledad , Carta Mauro Giovanni , Durand-Arias Sol , Eskin Mehmet , Fernández-Jiménez Eduardo , Freytes Marcela , Gureje Oye , Isahakyan Anna , Jaldo Rodrigo , Karam Elie G. , Khattech Dorra , Lindert Jutta , Martinez-Ales Gonzalo , Mascayano Franco , Mediavilla Roberto , Narvaez Javier , Nasser-Karam Aimee , Nishi Daisuke , Olaopa Olusegun , Ouali Uta , Puac-Polanco Victor , Ramírez Dorian E. , Ramírez Jorge , Rivera-Segarra Eliut , Rutten Bart P. F. , Santaella-Tenorio Julian , Sapag Jaime C. , Šeblová Jana , Soto María Teresa Solís , Tavares-Cavalcanti Maria , Valeri Linda , Sijbrandij Marit , Susser Ezra S. , Hoek Hans W. , Ven Els van der 
Published: July 2023

Abstract
Purpose
Healthcare workers (HCWs) were at increased risk for mental health problems during the COVID-19 pandemic, with data from previous crises suggesting women may be particularly vulnerable. The objective of the study was to examine individual and social factors that may be associated with gender differences in psychological distress and depressive symptoms among HCWs during the initial COVID-19 pandemic outbreak and to examine the consistency of these differences across a diverse range of countries.
Methods
Data were collected in a cross-sectional design between March 2020 and February 2021 as part of the COVID-19 HEalth caRe wOrkErS (HEROES) study. 32,410 HCWs recruited across 22 countries completed the General Health Questionnaire-12 (GHQ-12), the Patient Health Questionnaire-9 (PHQ-9), and questions about pandemic-relevant exposures.
Results
Consistently across countries, women reported elevated mental health problems compared to men. Women also reported increased COVID-19-relevant stressors, including less access to sufficient personal protective equipment and less support from colleagues than men; however, men reported increased contact with COVID-19 patients. At the country-level, HCWs working in countries with higher gender inequality reported lower levels of mental health problems. Higher COVID-19 mortality rates were associated with increased psychological distress among women but not among men.
Conclusion
Our findings suggest that among HCWs, women may have been disproportionately exposed to several COVID-19-relevant stressors at the individual and country-level. This highlights the importance of considering gender in emergency response efforts to protect women’s well-being and ensure adequate healthcare system preparedness during future public health crises.
Menaquinone Production by Engineering a DegU Quorum Sensing Circuit in Bacillus subtilis
Authors: huang Junbao , Huang XIlin , Liu Kun , Gao Xuli , Luo Yani , Wang Jian , Li Xiangfei , Zhao Ming , Xue Zhenglian , Liu Yan 
Published: July 2023

Abstract
Vitamin K2, as a menadione compound, has been a hot topic in international research in recent years. Previous work mainly focused on the manipulation of several genes in metabolic pathway, but did not pay attention to the overall regulation, which always failed to make the fermentation yield of the strain meet people's requirements. On this basis, we shifted the research focus from the knockout and overexpression of several genes in a single metabolic pathway to the overall regulation of bacteria. The effect of transcription regulation system on MK-7 production in Bacillus subtilis was studied by mining transcription regulation factors. We constructed a set of PhrG-RapG-DegU regulatory system by using quorum sensing signal molecules PhrG pentapeptide, RapG protein and regulatory factor DegU. By fine-tuning the expression of related genes, the content of MK-7 in the finally constructed BS06 in a 250 mL conical flask reached 102.47 mg/L, and the cell density was 28.677, which was basically the same as that of the original bacteria. Our experiment realized the efficient synthesis of MK-7 in Bacillus subtilis and ensured the stable growth of bacteria, which proved the effectiveness of this control strategy.
Comparison of clinical characteristics and complication predictors of IgA vasculitis between pediatric and adult patients in China
Authors: Zhu qihui , Liu Jia , He Yufei , 王 玉连 , Wu Jianhua 
Published: July 2023

Abstract
Background
IgA vasculitis (IgAV) is an allergic disease of the vascular wall, the prognosis of the disease in adults is usually worse than that in children, but there is a lack of study to compare the clinical characteristics and complication predictors of IgAV between pediatric and adult patients.
Methods
This retrospective study included 158 cases of IgAV from the Departments of Dermatology, Pediatrics, Nephrology and Gastroenterology of Changhai Hospital. Details of the clinical characteristics, laboratory index and complication were collected.
Results
Multiple logistic regression analysis of the 158 IgAV patients (79 in children group and 79 in adult group) showed that the risk factors for gastrointestinal (GI) involvement were PLR > 184 in children group (OR = 6.963, P = 0.001) vs. NEU > 8.4 (OR = 4.332, P = 0.023) and NLR > 5.2 (OR = 4.077, P = 0.048) in adult group. Risk factors for renal involvement were age (OR = 0.818, P = 0.017), ENR > 2.6 (OR = 4.305, P = 0.034) and PLR > 04 (OR = 0.939, P = 0.024) in children group vs. RDW > 13.2 (OR = 5.453, P = 0.019) and ENR > 0.2 (OR = 4.667, P = 0.010) in adult group. Risk factors for arthralgia were the season of disease onset (OR = 0.609, P = 0.040) and NEU > 9.1 (OR = 7.761, P = 0.003) in children group vs. NEU > 7.0 (OR = 7.237, P = 0.07), LYM > 2.8 (OR = 9.129, P = 0.009), and PLT > 270 (OR = 6.466, P = 0.011) in adult group.
Conclusions
Different complication predictors of IgAV were observed between pediatric and adult patients, and different values of the same indicators in predicting the occurrence of complications were calculated, suggesting that the predictions should be differentiated in different patients with the same disease.
Is the entropy-weighted water quality index a suitable index for evaluating the groundwater quality in Ha'il, Saudi Arabia?
Authors: Alfaleh Ayman , Ben Khedher Nidhal , Alviz-Meza Aníbal 
Published: July 2023

Abstract
This study examined the groundwater quality in Ha'il according to World Health Organization (WHO) standards using the entropy-weighted water quality index (EWQI) more accurately. The study investigated several parameters in groundwater quality and found that more than 75% of the changes in Ha'il can be attributed to four main factors (MF1, MF2, MF3, and MF4). The MF1 was found to have the biggest role in controlling more than 33% of the changes in the water quality. Due to the entropy calculations for each parameter, zinc was found to have the highest rate of influence on groundwater quality. The results of the EWQI showed that the highest number of samples (76%) had Rank 2 and good quality. Also, it was tried to couple EWQI with machine-learning techniques to improve the model performance and survey the related results in this study. The results showed that the efficiency criteria are improved noticeably. Root-mean-square error decreases by 25%, and the determination coefficient (R2) increases by 27.94%.
Long-term Effectiveness of the National Diabetes Quality Assessment Program in South Korea
Authors: Huh Ji Hye , Kwon Serim , Kim Gui Ok , Kim Bo Yeon , Ha Kyoung Hwa , Kim Dae Jung 
Published: July 2023

OBJECTIVE
This study examined the long-term effectiveness of the national diabetes quality assessment program (NDQAP) in diabetes.

RESEARCH DESIGN AND METHODS
From the Health Insurance Review and Assessment Service database, 399,984 individuals with diabetes who visited a primary care clinic from 1 July 2012 to 30 June 2013 were included and followed up until 31 May 2021. The NDQAP included five quality assessment indicators: regular outpatient visits, continuity of prescriptions, regular testing of glycated hemoglobin and lipids, and regular fundus examination. Cox proportional hazards models estimated hazard ratios (HRs) and 95% confidence intervals (CIs) for diabetes complications and all-cause mortality by the achievement of quality assessment indicators.

RESULTS
During the mean follow-up duration of 7.6 ± 1.8 years, 20,054 cases (5.0%) of proliferative diabetic retinopathy (PDR), 6,281 end-stage kidney diseases (ESKD; 1.6%), 1,943 amputations (0.5%), 9,706 myocardial infarctions (MIs; 2.4%), 26,975 strokes (6.7%), and 35,799 all-cause mortality (8.9%) occurred. Each achievement of quality assessment indicator was associated with a decreased risk of diabetes complications and all-cause mortality. Individuals who were managed in high-quality institutions had a lower risk of PDR (HR 0.82; 95% CI 0.80–0.85), ESKD (HR 0.77; 95% CI 0.73–0.81), amputation (HR 0.75; 95% CI 0.69–0.83), MI (HR 0.85; 95% CI 0.82–0.89), stroke (HR 0.86; 95% CI 0.84–0.88), and all-cause mortality (HR 0.96; 95% CI 0.94–0.98) than those who were not managed in high-quality institutions.

CONCLUSIONS
In Korea, the achievement of NDQAP indicators was associated with a decreased risk of diabetes complications and all-cause mortality.
Analisis tingkat kepercayaan diri siswa pada pembelajaran Penjas di SD Negeri 82 Bengkulu Tengah
Authors: Nopiyanto Yahya Eko , Insanistyo Bayu , Raibowo Septian , Prabowo Andika , Andriyani Mas’ullah , Ibrahim Ibrahim 
Published: July 2023

Masalah: Kurangnya kemampuan siswa untuk mengekspresikan dirinya dalam melakukan berbagai tugas gerak dalam pembelajaran penjas.
Tujuan:Tujuan penelitian ini adalah menganalisis kepercayaan diri siswa dalam pembelajaran penjasorkes di SD Negeri 82 Bengkulu Tengah.
Metode:Deskriptif kuantitatif digunakan untuk mencapai tujuan penelitian. Sampel dalam penelitian ini adalah 25 siswa yang berasal dari kelas 4 dan 5. Instrumen yang digunakan berupa angket. Data dianalisis berdasarkan pada nilai rerata dan standar deviasi untuk menentukan kategori tingkat kepercayaan diri.
Hasil:Hasil analisis menunjukkan bahwa 1 siswa memiliki kepercayaan diri rendah, 4 siswa memiliki kepercayaan diri sedang, 15 siswa memiliki kepercayaan diri tinggi, dan 5 siswa memiliki kepercayaan diri sangat tinggi.
Kesimpulan:Berdasarkan analisis data dapat disimpulkan bahwa siswa SD Negeri 82 Bengkulu Tengah memiliki kepercayaan diri yang tinggi untuk mengikuti kegiatan pembelajaran penjas. Penelitian ini memiliki keterbatasan karena tidak mendeskripsikan faktor-faktor yang mempengaruhi kepercayaan diri siswa untuk mengikuti pembelajaran penjas. Hasil penelitian ini memperluas informasi khususnya pada kepercayaan diri siswa untuk mengikuti kelas penjas.
Economic burden of beta-thalassaemia major receiving hypertransfusion therapy at a public hospital in Mumbai
Authors: UCHIL ASHWIJA , MURANJAN MAMTA , GOGTAY NITHYA J. 
Published: July 2023

Background
Treating beta-thalassaemia major may entail high costs with considerable out-of-pocket expenditure. Therefore, determination and valuation of the economic costs of a common haemoglobinopathy such as beta-thalassaemia major in India may provide insights to evolve policies for reduction or elimination of the disease. We estimated economic burden of beta-thalassaemia major in Mumbai in terms of cost to the family and the healthcare system.

Methods
This single-centre, prospective, cross-sectional, non-interventional study included children <12 years of age treated at the thalassaemia day care centre of a public hospital in Mumbai. The demographic data and treatment-related information was recorded. Cost of illness was studied from a societal perspective by the prevalence-based approach. Direct (medical and non-medical), indirect (loss of wages and loss of school days) and intangible costs (closed-ended iterative bidding) were calculated for each patient by interview.

Results
The total annual cost of treating 130 children with beta-thalassaemia major in Mumbai was ₹86 72 412 (US$ 127 535) or ₹66 710 (US$ 981) per patient per year and ₹12 82 30 412 (US$ 1 885 741) including intangible costs. Direct costs contributed to 94% of the cost of illness with chelation therapy (23%) and blood investigations (21%) being major contributors. Direct and indirect costs correlated significantly with duration of blood transfusion (p<0.05 and p=0.006, respectively), whereas indirect costs correlated with socioeconomic status (rho=0.25).

Conclusion
The majority (94%) of costs incurred by families for treatment of beta-thalassaemia major are direct costs, especially expenses for chelation and blood investigations. Even at subsidized rates, financial burden to the families from lower socioeconomic strata is likely to be considerable as these are out-of-pocket expenses. In consideration of the economic impact of treating beta-thalassaemia major in individual families, the healthcare system and society, it is prudent to promote and pursue long-term and short-term measures with urgent emphasis on prevention as a public health activity at the national level in India.
Photobiomodulation may enhance cognitive efficiency in older adults: a functional near-infrared spectroscopy study
Authors: Lee Tsz-lok , Chan Agnes S. 
Published: July 2023

IntroductionThe relative oxygenated hemoglobin (HbO) measured using functional near-infrared spectroscopy (fNIRS) has been considered as an index for cognitive loading, with the more difficult the task, the higher the level. A previous study reported that young adults who received transcranial photobiomodulation (tPBM) showed a reduced HbO of a difficult task, suggesting that tPBM may enhance cognitive efficiency. The present study further investigated the effect of tPBM on cognitive efficiency in older adults.MethodsThirty participants received a single tPBM on the forehead for 350 s. Before and after tPBM, their HbO in the visual span task with various difficulties was measured with fNIRS.ResultsAfter tPBM, participants exhibited significantly lower HbO in a harder (span 7) but not an easier level (span 2) of the task, but their behavioral performance remained unchanged. In addition, factors affecting the reduction of HbO were examined, and the results showed that individuals with better memory (as measured by a 30-min delayed recall test) showed more reduction of HbO.DiscussionThe results suggest that tPBM may enhance cognitive efficiency, with individuals with better memory tend to benefit more.
Protective Effect of Electroacupuncture on Chemotherapy-Induced Salivary Gland Hypofunction in a Mouse Model
Authors: Nguyen Thanh-Hien Vu , Chiu Kuo-Chou , Shih Yin-Hwa , Liu Chung-Ji , Bao Quach Tran Van , Hsia Shih-Min , Chen Yi-Hung , Shieh Tzong-Ming 
Published: July 2023

Radiotherapy and chemotherapy can impair salivary gland (SG) function, which causes xerostomia and exacerbate other side effects of chemotherapy and oral infection, reducing patients’ quality of life. This animal study aimed to assess the efficacy of electroacupuncture (EA) as a means of preventing xerostomia induced by 5−fluorouracil (5−FU). A xerostomia mouse model was induced via four tail vein injections of 5−FU (80 mg/kg/dose). EA was performed at LI4 and LI11 for 7 days. The pilocarpine-stimulated salivary flow rate (SFR) and salivary glands weight (SGW) were recorded. Salivary immunoglobulin A (SIgA) and lysozyme were determined via enzyme-linked immunosorbent assay (ELISA). SG was collected for hematoxylin and eosin staining to measure acini number and acinar cell size. Tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and aquaporin 5 (AQP5) mRNA expressions in SG were quantified via RT-qPCR. 5−FU caused significant decreases in SFR, SGW, SIgA, lysozyme, AQP5 expression, and acini number, while TNF-α and IL-1β expressions and acinar cell size were significantly increased. EA treatment can prevent 5−FU damage to the salivary gland, while pilocarpine treatment can only elevate SFR and AQP5 expression. These findings provide significant evidence to support the use of EA as an alternative treatment for chemotherapy-induced salivary gland hypofunction and xerostomia.
Reasons, Weight, and Hybrid Approaches to the Metaphysics of Practical Normativity
Authors: Davia Cory 
Published: July 2023

AbstractIn virtue of what do some considerations count in favor or against actions? Some philosophers have recently been interested in hybrid answers to this question. For instance, it might be that some facts about reasons are brute, and some are explained in terms of agents’ acts of will. Such views face a challenge: they need a story about how reasons grounded in one way combine with reasons grounded in other ways to yield overall verdicts about what to do. This paper assesses the two most prominent accounts of how that happens, and offers an alternative that captures what's most plausible about each.
Sosialisasi Hukum Keluarga Bidang Perceraian di Gampong Paloh Lada Kecamatan Dewantara
Authors: Jumadiah Jumadiah , Jamaluddin Jamaluddin , Sutriani Sutriani , Hamdani Hamdani 
Published: July 2023

Perkawinan merupakan ikatan lahir batin antara seorang pria dengan seorang wanita dengan maksud guna membina sebuah keluarga atas ridho dari Allah SWT. Dalam hukum positif di Indonesia sebagaimana tercantum dalam Undang-Undang Nomor.1 Tahun 1974 tentang perkawinan, dimana dalam undang-undang tersebut telah diatur yang secara detail tentang perkawinan, namun realitanya masih banyak yang melanggar peraturan undang-undang, undang-undang tersebut menganut prinsip untuk mempersulit perkawinan. Karena masih ada perkawinan usia di bawah umur tertentu, maka kecenderungan perceraian mudah terjadi, bahkan jika perceraian merupakan upaya terakhir untuk menjaga keutuhan keluarga. Pertanyaannya adalah bagaimana mengurangi perceraian keluarga di masyarakat Gampong Paloh Lada, maka tujuan sosialisasi untuk memberi pemahaman agar perkawinannya dapat dipertahankan agar terwujudnya keluarga yang sakinah mawaddah dan warahmah, Metode pelaksanaan yang dipakai adalah ceramah dan tanya jawab. Hasil dari kajian ini masyarakat Gampong Paloh Lada memiliki pengetahuan tentang hukum keluarga dan mampu menerapkan dalam keluarga.
Swakaryaloka: Naturalist based street chic creation
Authors: Trisnadewi Anak Agung Sagung Istri , Ratna C.S Tjok Istri , Remawa Anak Agung Gede Rai 
Published: July 2023

The creation of this naturalist-based street chic ready-to-wear fashion was made with the aim of minimizing liquid waste from chemicals and displaying environmentally friendly clothing. The method used is an experimental method with natural dye techniques, namely dyeing or coloring derived from plants and eco print techniques, which are unique in the form of leaf traces with contemporary art. The creative process used is the ten steps of creating a frangipani fashion design, including idea exploration, research, aesthetic element analysis, design development, sample making, promotion, branding affirmations, to the fashion business. The final collection is entitled Swakaryaloka which is a creative work of art in visualizing clothing using natural dyes that utilize the surrounding nature as an object to produce an environmentally friendly fashion product. The creation of this street chic fashion design is adapted to the trend of spirituality, a change in mindset that is more grounded in preserving nature and respect for the work process. There is a total of 9 looks which are divided into three groups, namely memorable, contemporary, and hopeful. The groups displayed environmentally friendly clothing that had a storyline from the condition of the color of the polluted water to the color of the water being clean or normal. Each look is analyzed using design elements and principles using aesthetic theory.
Keywords: natural dye, eco print, spirituality, street chic.
Availability, price, and affordability of antiseizure medicines in Addis Ababa, Ethiopia
Authors: Hailemariam Fikreselam Habte , Shifa Mekdes , Kassaw Chalelgn 
Published: July 2023

AbstractObjectiveUp to 70% of people living with epilepsy could become seizure‐free with the appropriate use of antiseizure medicines. However, three quarters of people with epilepsy living in low‐income countries do not get the treatment they need and also do not access antiseizure medicines. The purpose of this study was to assess the availability, price, and affordability of antiseizure medicines in Addis Ababa, Ethiopia.MethodsA cross‐sectional study was done in selected pharmacies using a questioner developed after the modification of World Health Organization/Health Action International methodology. Data on the availability and price of lowest‐priced generics and originator brand antiseizure medicines from essential medicines list in Ethiopia were collected from seven public sectors, five private sectors, and seven other sectors (five Kenema Public Community and two Red Cross Pharmacies) in Addis Ababa between 09 May and 31 2022. The data were analyzed using the modified World Health Organization/Health Action International workbook part I excel sheet. Descriptive results were reported in text and table format.ResultsThe overall availability of lowest‐priced generics medication was 52%. The availability of lowest‐priced generics was 62.86%, 30%, 55%, and 50% in public, private, Red Cross, and Kenema Public Community Pharmacies, respectively. The median price ratio in the public, private, Red Cross, and Kenema Public Community Pharmacy was 1.45, 3.72, 1.46, and 1.7, respectively. All the medications were unaffordable. Patients may be required to pay more than 6‐month wage to purchase standard treatment for 1 month only.SignificanceThe overall availability of antiseizure medicines was lower than the WHO target for noncommunicable diseases. All the available medicines were unaffordable.
Underestimated olfactory domains in Huntington's disease: odour discrimination and threshold
Authors: Amini E , Rohani M , Habibi S A H , Azad Z , Yazdi N , Cubo E , Hummel T , Jalessi M 
Published: July 2023

AbstractBackgroundOlfaction has recently found clinical value in prediction, discrimination and prognosis of some neurodegenerative disorders. However, data originating from standard tests on olfactory dysfunction in Huntington's disease are limited to odour identification, which is only one domain of olfactory perceptual space.MethodTwenty-five patients and 25 age- and gender-matched controls were evaluated by the Sniffin’ Sticks test in three domains of odour threshold, odour discrimination, odour identification and the sum score of them. Patients’ motor function was assessed based on the Unified Huntington's Disease Rating Scale.ResultsCompared with controls, patients’ scores of all olfactory domains and their sum were significantly lower. Besides, our patients’ odour threshold and odour discrimination impairments were more frequently impaired than odour identification impairment (86 per cent and 81 per cent vs 34 per cent, respectively).ConclusionOlfactory impairment is a common finding in patients with Huntington's disease; it is not limited to odour identification but is more pronounced in odour discrimination and odour threshold.