bluuebunny/crossref_metadata_2025_split huggingface dataset:
Letter: Chinese herbal medicine Curcumin‐QingDai (CurQD) – A good treatment option for active ulcerative colitis?
Authors: Wu Xiaojiao , Yang Yang 
Published: August 2023

LINKED CONTENTThis article is linked to Yanai et al papers. To view these articles, visit https://doi.org/10.1111/apt.17538 and https://doi.org/10.1111/apt.17655
Letter: Chinese herbal medicine Curcumin–QingDai (CurQD)—A good treatment option for active ulcerative colitis? Authors' reply
Authors: Yanai Henit , Salomon Nir , Ben‐Horin Shomron , Kopylov Uri 
Published: August 2023

LINKED CONTENTThis article is linked to Yanai et al papers. To view these articles, visit https://doi.org/10.1111/apt.17538 and https://doi.org/10.1111/apt.17647
Editorial: Recent advances in fibrosis assessment for metabolic dysfunction‐associated fatty liver disease–Authors' reply
Authors: Gao Feng , Byrne Christopher D. , Targher Giovanni , Zhuo Shuangmu , Zheng Ming‐Hua ,   CHESS‐MAFLD consortium
Published: August 2023

LINKED CONTENTThis article is linked to Zhan et al papers. To view these articles, visit https://doi.org/10.1111/apt.17635 and https://doi.org/10.1111/apt.17651
Possible roles of bone morphogenetic protein 4 in regulating endometrial function in cows
Authors: Koizumi Yuki , Hayashi Ken‐Go , Sakumoto Ryosuke 
Published: August 2023

AbstractThis study investigated the expression dynamics of bone morphogenetic protein 4 (BMP4) and its receptors (BMPR1A, BMPR1B, and BMPR2) in bovine endometrium and examined the physiological function and regulatory mechanism of BMP4 expression. The messenger RNA (mRNA) expression of BMP4 and its receptors was detected in bovine endometrium of both ipsilateral (corpus luteum [CL]‐side) and contralateral (non‐CL‐side) uterine horns during the estrous cycle and early pregnancy. BMP4 protein levels were higher in the endometrial tissues obtained from those cows in early pregnancy than in the estrous cycle. Immunohistochemical analysis showed that BMP4 and its receptors were localized in endometrial epithelial cells. The addition of BMP4 to cultured endometrial epithelial cells did not affect caspase‐3/‐8 mRNA expression, whereas it significantly inhibited cell proliferation. Both prostaglandin (PG) E2 and PGF2α concentrations in the culture supernatant were decreased when stimulated by BMP4. Furthermore, BMP4 mRNA expression was increased by stimulation with tumor necrosis factor‐α (TNF) and interferon‐γ (IFNG). In conclusion, BMP4 is produced in bovine endometrial epithelial cells and may contribute to the regulation of cell proliferation and suppression of PG secretion through autocrine or paracrine mechanisms. BMP4 expression in the bovine endometrium may be regulated by TNF and IFNG.
“Make it better for the women and babies who come after me”: Findings from women in Australia completing the international Babies Born Better survey
Authors: Young Kate , Miller Yvette D. 
Published: August 2023

AbstractBackgroundWoman‐centered maternity service delivery is endorsed by Australian federal health policy. Despite this, little evaluation of maternity care is conducted through the lens of women. We examined the responses of women birthing in Australia to the international Babies Born Better 2018 (Version 2) open‐response survey.MethodsAn online international survey was distributed primarily by means of social media for women who had given birth in the last 5 years. In addition to closed‐ended questions to describe the sample, a series of open‐ended questions recorded women's experiences and satisfaction with their maternity care and place of birth.ResultsOf 1249 women who reported birthing their most recent baby in Australia and speaking English, 84% responded to at least one open‐ended evaluation question. We thematically analyzed the data to identify three related themes of safety, choice, and respect for women. Women's experiences of these were closely tied to their model of care; those birthing at home with a private midwife more so reported positive experiences than those discussing obstetric care or, to a lesser extent, midwifery‐led care in a hospital. There was a strong preference and need for (1) access to affordable care with a known practitioner from early pregnancy to postpartum, and (2) individualized care with the removal of restrictive hospital policies not aligned with woman‐centered practice.DiscussionThis is the first Australian national study of women's maternity experiences and evaluations. Consistent with previous state‐based research, women birthing in Australia continue to report maternity “care” that is physically and emotionally harmful. They also stated a need to address the psychosocial aspects of becoming a mother, in addition to the biological ones. Women and other birthing people must be at the center of defining quality maternity health service delivery, and services must be accountable for preventing and addressing harm, as defined by all birthing people.
The moderating roles of resilience and social support in the relationships between bullying victimization and well‐being among Chinese adolescents: Evidence from PISA 2018
Authors: Zhang Ying , Li Hao , Chen Gaowei , Li Bo , Li Na , Zhou Xin 
Published: August 2023

AbstractBullying victimization can undermine adolescents' well‐being. However, few studies have comprehensively investigated the contributions of various victimization forms to well‐being and compared which forms were more harmful than others. Evidence on whether resilience and social support moderate such associations is also limited. Using a sample of 12,058 Chinese adolescents in the Programme for International Student Assessment (PISA) 2018, this cross‐sectional study aimed to (1) investigate the associations of physical, verbal and relational victimization with well‐being; (2) compare the strengths of these associations; and (3) examine the moderating roles of resilience and teacher and parent support in these associations. Results showed that three victimization forms were associated with poorer well‐being. Relational and physical victimization were more harmful to most studied well‐being outcomes than verbal victimization. Furthermore, resilience weakened the negative effects of physical victimization on negative affect and life satisfaction but aggravated the negative effects of verbal victimization on both outcomes and the negative effect of relational victimization on school belonging. Teacher support intensified the negative effects of physical victimization on school belonging. Parent support was not effective in regulating the victimization–well‐being association. The findings underscored the detrimental effects of bullying victimization on adolescents' well‐being and the potentially harmful sides of resilience and social support. Implications for bullying prevention were discussed.
Moral reasoning behind the veil of ignorance: An investigation into perspective‐taking accessibility in the context of autonomous vehicles
Authors: Bruno Giovanni , Spoto Andrea , Sarlo Michela , Lotto Lorella , Marson Alex , Cellini Nicola , Cutini Simone 
Published: August 2023

AbstractPerspective‐taking (PT) accessibility has been recognized as an important factor in affecting moral reasoning, also playing a non‐trivial role in moral investigation towards autonomous vehicles (AVs). A new proposal to deepen this effect leverages the principles of the veil of ignorance (VOI), as a moral reasoning device aimed to control self‐interested decisions by limiting the access to specific perspectives and to potentially biased information. Throughout two studies, we deepen the role of VOI reasoning in the moral perception of AVs, disclosing personal and contingent information progressively throughout the experiment. With the use of the moral trilemma paradigm, two different VOI conditions were operationalized, inspired by the Original Position theory by John Rawls and the Equiprobability Model by John Harsanyi. Evidence suggests a significant role of VOI reasoning in affecting moral reasoning, which seems not independent from the order in which information is revealed. Coherently, a detrimental effect of self‐involvement on utilitarian behaviours was detected. These results highlight the importance of considering PT accessibility and self‐involvement when investigating moral attitudes towards AVs, since it can help the intelligibility of general concerns and hesitations towards this new technology.
Structure and morphology of an active conjugate relay zone, Messina Strait, southern Italy
Authors: Dorsey Rebecca J. , Longhitano Sergio G. , Chiarella Domenico 
Published: August 2023

AbstractMessina Strait is a narrow fault‐bounded marine basin that separates the Calabrian peninsula from Sicily in southern Italy. It sits in a seismically active region where normal fault scarps and raised Quaternary marine terraces record ongoing extension driven by southeastward rollback of the Calabrian subduction zone. A review of published studies and new data shows that normal faults in the Messina Strait region define a conjugate relay zone where displacement is transferred along strike from NW‐dipping normal faults in the northeast (southern Calabria) to the SE‐dipping Messina‐Taormina normal fault in the southwest (offshore eastern Sicily). The narrow marine strait is a graben undergoing active subsidence within the relay zone, where pronounced curvature of normal faults results from large strain gradients and clockwise rotations related to fault interactions. Based on regional fault geometries and published age constraints, we infer that normal faults in southern Calabria migrated northwest while normal faults in NE Sicily migrated southeast during the past ca. 2–2.5 Myr. This pattern has resulted in tectonic narrowing of the strait through time by inward migration of facing normal faults and rapid mantle‐driven uplift.
Mr Speaker: The changing nature of parliamentary debates on immigration in Canada
Authors: Pendakur Ravi , Sarna Sabrina 
Published: August 2023

AbstractWe use correspondence analysis to look at the changing nature of political debates in the Canadian House of Commons concerning immigration over a five‐decade period. Using data drawn from the Linked Parliamentary Data (LiPaD) project we assess the way in which immigration policy and issues are discussed by different political parties from September of 1968 to June of 2019. We look at debates in five of the longest Prime Ministers’ mandates. In doing so, we trace changes in both emphasis and rhetoric by political party. We find that party political views on immigration became more polarized with the breakup of the Progressive Conservative party in the early 1990s. Liberal party views moved toward to the left of the spectrum while the Reform/Alliance/Conservative Party of Canada parties moved toward the right and became increasingly entrenched until 2015. After that, the Conservatives and the Liberals moved closer to the centre. The New Democratic Party was the most consistent in its views over time, focusing on issues of humanitarianism as well as broad policy issues.
Feasibility study for a fully decentralized clinical trial in participants with functional constipation symptoms
Authors: Huh Ki Young , Chung Woo Kyung , Park Jiyeon , Lee SeungHwan , Kim Min‐Gul , Oh Jaeseong , Yu Kyung‐Sang 
Published: August 2023

AbstractDecentralized clinical trials (DCTs) leverage digital technologies to reduce dependency on study sites and intermediaries. DCT should be balanced with accessibility and data reliability while meeting regulatory requirements. Here, we conducted a pilot study for functional constipation symptoms to investigate the feasibility of DCT. The study was an open, fully remote, randomized clinical trial in participants who had functional constipation symptoms. Electronic consent was obtained remotely, and study volunteers were screened through web‐based questionnaires. Subjects were randomized to either receive Lactobacillus and vitamin C supplements or vitamin C alone in a 1:1 ratio, which were delivered directly to subjects. Subjects kept track of bowel diaries daily during the 1‐week baseline and 2‐week treatment period using mobile applications. Bowel symptoms and the validity of the records were descriptively evaluated. A total of 30 subjects were randomized and completed the study. A total of 26.7% of subjects resided outside of the metropolitan area. Two‐week Lactobacillus treatments increased the number of defecations (+0.80 vs. +0.46 times per week) and decreased the defecation time (−3.94 h vs. −1.62 h) compared to the comparator group. Overall, 67.1% of bowel diary records were completed in accordance with the schedule whereas 32.9% were not. Implementation of DCTs can facilitate geographic accessibility but should be guaranteed for data reliability. Prompt detection of errors and response using objective metrics would be required.
Gossypol improves myocardial dysfunction caused by sepsis by regulating histone acetylation
Authors: Shi Xiaohui , Lv Xinwei , Xiao Dong 
Published: August 2023

AbstractGossypol is a polyphenol from the cotton plant with anti‐inflammatory and anti‐oxidation activities and can also function as a histone deacetylase (HDAC) inhibitor. Sepsis is an inflammatory disease with high mortality. Inflammation, oxidative stress, and epigenetic factors are involved in sepsis and its complications. The biological activities of gossypol strongly suggest the potential effects of gossypol on sepsis. In the present study, the beneficial effects of gossypol on sepsis were evaluated. We established a cecal ligation and puncture (CLP) mouse model of sepsis and treated CLP mice with gossypol. The survival rate, serum level of myocardial injury markers, and myocardial level of oxidation markers were measured. We also administered gossypol to lipopolysaccharide (LPS)‐treated primary cardiomyocytes. The production of pro‐inflammatory cytokines, activation of protein kinase B (AKT) and IκB kinase (IKK), acetylation of histone, and expression of HDACs were measured. Gossypol prevented the death of CLP mice and ameliorated myocardial damage in CLP mice. Moreover, gossypol decreased oxidative factors, while promoting antioxidant production in CLP mice. Gossypol prevented LPS and cytosine‐phosphate‐guanosine‐induced expression of pro‐inflammatory cytokines, suppressed LPS‐induced activation of AKT and IKK, inhibited histone acetylation, and decreased the expression of HDACs. In conclusion, gossypol ameliorates myocardial dysfunction in mice with sepsis.
Perceived contact with friends from lower socioeconomic status reduces exclusion based on social class
Authors: Gönül Buse , Sahin‐Acar Basak , Killen Melanie 
Published: August 2023

AbstractThis study investigated children's and adolescents’ reasoning about intergroup exclusion based on social class from educational opportunities in Türkiye. The role of children's and adolescents’ perceived contact with friends from different socioeconomic backgrounds on their evaluations of exclusion and personal solutions to the exclusion was also examined. Participants (N = 270) included 142 children (8–10 years old, Mage = 9.80; SD = 0.82; 53.5% girls) and 128 adolescents (14–16 years old, Mage = 15.46; SD = 0.91, 61.7% girls) from lower (N = 144) and higher (N = 126) socioeconomic backgrounds. Results showed that while most participants viewed social class‐based exclusion as wrong, adolescents were more likely to view it as wrong than were children. Adolescents from lower SES approached social class‐based exclusion as less acceptable than did adolescents from higher SES who referred to expectations about conformity to authority and the status quo. Moderation analyses showed that for adolescents from higher SES, higher perceived contact with friends from lower SES was associated with decreased acceptability of exclusion and increased motivation to provide equity.Research Highlights
Overall, adolescents living in a country with economic instability evaluated social class‐based exclusion from educational opportunities among peers as unfair and wrong.
Adolescents from lower SES viewed social class‐based exclusion as less acceptable than did adolescents from higher SES.
Adolescents from higher SES expected that excluders’ intentions were motivated by conforming to authority and supporting the status quo more frequently than did children.
For adolescents from higher SES, perceived contact with friends from lower SES was associated with decreased acceptability of exclusion and increased motivation to provide equity.
The usefulness of echo‐based hemodynamic parameters in cardiac resynchronization therapy with conduction system pacing for optimal device programing
Authors: Boczar Krzysztof , Ząbek Andrzej , Golińska‐Grzybała Karolina , Sławuta Agnieszka , Dębski Maciej , Gajek Jacek , Holcman Katarzyna , Gackowski Andrzej , Lelakowski Jacek , Małecka Barbara 
Published: August 2023

AbstractBackgroundHis bundle pacing (HBP) has proved to be a valuable alternative enabling the physiological activation of cardiac contraction in cardiac resynchronization therapy (CRT). At present, however, little is known about the optimal method of programming of the His bundle‐paced CRT systems in terms of achieving the best cardiac output.AimThe aim of this study was to evaluate the impact of cardiac resynchronization therapy with conduction system pacing (CRT+CSP) on echo‐based hemodynamic parameters in the early post‐operative measurements.MethodsThe study enrollment criteria included: permanent atrial fibrillation, heart failure and bundle branch block. All patients underwent implantation of CRT + HBP. During the post‐operative phase, we aimed to optimize HOT‐CRT settings in order to achieve the greatest cardiac output assessed by complex echocardiographic measurements.ResultsThe study included 21 patients, mean age 71.2 (6.3) years, predominantly men (71.4%) with non‐ischemic cardiomyopathy 62%. All patients had heart failure with NYHA functional class III and IV (81%). Mean left ventricular ejection fraction was 27.5 (9.7%). The mean duration of the QRS complex was 148.8 ms. The effects of resynchronization pacing: HBP alone, HBP with left ventricular pacing, HBP with biventricular pacing (BiV) and BiV without HBP ​​were analyzed consecutively. HBP combined with left ventricular pacing demonstrated the best hemodynamic response.ConclusionHis bundle pacing coupled with LV pacing proved to be the most advantageous pacing program setting with regard to cardiac output. Moreover, it performed better than biventricular pacing and significantly better than RV pacing.
Sublethal effects of kleptoparasitism on experimental social spider colonies
Authors: Straus Samantha , Avilés Leticia 
Published: August 2023

AbstractA defining feature of parasitism is the harm parasites cause to their host via a reduction in lifetime reproductive success. Harm, also referred to as “virulence,” may involve host mortality or sublethal effects, such as a decreased body condition or protracted development of immature individuals. We considered a system where colonies of the social spider Anelosimus eximius serve as hosts to confamilial kleptoparasitic spiders that steal food resources. In a laboratory experiment with parasitized and non‐parasitized colonies, we tested whether this host–parasite interaction meets the criterium of harm to host individuals and colonies. We assessed survival and measured scaled mass indices (SMI) before and after the experimental period. Linear mixed effects models demonstrated that colonies exposed to kleptoparasites had lower SMI values at the end of the experiment compared to controls, but found no effect of kleptoparasitism on mortality in treatment and control groups. We conclude that kleptoparasites meet the criterium of harm to their host to be considered parasitic and provide the first empirical measure of virulence for this study system.
Experimental study of the strengthening effect: A novel fatigue life prediction method for variable amplitude loads
Authors: Jiang Renjie , Yang Xiaoguang , Shi Duoqi , Cheng Muwei , Sun Yantao 
Published: August 2023

AbstractThe strengthening effect of low‐amplitude loading at elevated temperatures was investigated experimentally. A powder metallurgy nickel‐based superalloy FGH96 was preloaded with different cycle numbers and stress levels, and the residual fatigue life was tested under subsequent high‐amplitude loads. The results show that when the number of preloading cycles is in a specific range, the residual fatigue life is higher than that of the virgin specimen under the same load. A novel damage accumulation model was proposed to incorporate the strengthening effect into the life prediction framework. The proposed model was validated using experimental results for various materials in the literature. The mechanism of the strengthening effect of FGH96 was discussed based on electron backscatter diffraction (EBSD) analysis.
Planktonic archaea reveal stronger dispersal limitation and more network connectivity than planktonic bacteria in the Jinsha River of southwestern China
Authors: Cui Ge , Chen Juan , Wang Chao , Wang Peifang , Zhang Bo , Gao Han , Fu Rui 
Published: August 2023

Abstract

Planktonic archaea and bacteria play important roles in biogeochemical cycling, but their biogeographical patterns and underlying ecological processes remain poorly understood, particularly in large‐scale rivers.

We collected 43 water samples covering a 2279 km reach of the Jinsha River, one of the largest rivers in southwest China, and performed high‐throughput sequencing analysis on planktonic archaeal and bacterial communities. Partial Mantel analysis and neutral model were used to assess the factors influencing microbial distributions. The associations among different microbial species and their geographical distribution patterns were linked through co‐occurrence networks, and the putative key taxa in the archaeal and bacterial networks were analysed.

The Shannon index of both archaeal and bacterial communities was highest in the midstream reach. The Pielou's evenness of archaea did not vary among the three reaches, whereas those of bacteria increased from upstream to downstream. The archaeal and bacterial community compositions were significantly different in the three reaches, but the differences among the bacterial communities were greater than among the archaeal communities.

Both dispersal limitation and environmental selection affected the community compositions of the archaea and bacteria, but dispersal limitation was the most influential factor. Compared to archaea, bacteria were less affected by dispersal limitation and more by environmental selection.

The co‐occurrence network analysis demonstrated that, compared with the bacterial network of all sites, the archaeal network with larger graph density had higher connectivity and complexity, but a lower proportion of negative correlations. The putative key taxa belonged to Nitrososphaeraceae and Candidatus_Nitrocosmicus from the archaeal community, and Hydrogenophaga and Sphingorhabdus from the bacterial community.

Taken together, these findings demonstrated that the planktonic archaea were more dispersal‐limited and showed more network connectivity than the planktonic bacteria in the Jinsha River. This study enhances our understanding of the biogeographical distribution patterns and underlying ecological processes of planktonic microorganisms over large‐scale freshwater systems.