bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hepcidin and Iron Status in Patients With Inflammatory Bowel Disease Undergoing Induction Therapy With Vedolizumab or Infliximab
Authors: Loveikyte Roberta , Bourgonje Arno R , van der Reijden Johannes J , Bulthuis Marian L C , Hawinkels Lukas J A C , Visschedijk Marijn C , Festen Eleonora A M , van Dullemen Hendrik M , Weersma Rinse K , van Goor Harry , van der Meulen-de Jong Andrea E , Dijkstra Gerard 
Published: February 2023

Abstract

Background
Hepcidin, the systemic iron regulator, could be critical in differentiating iron deficiency (ID) from functional iron restriction in inflammatory bowel disease (IBD). We assessed hepcidin as a diagnostic ID marker and explored the relationship between hepcidin and its regulators in patients with IBD undergoing induction therapy with infliximab (IFX) or vedolizumab (VEDO).

Methods
Patients with active IBD receiving induction therapy with IFX or VEDO were included. Serum samples at baseline and after 6 weeks of induction therapy were analyzed for hepcidin, inflammation- and hypoxia-associated cytokines, and oxidative stress. Data were analyzed by stratifying based on the response at week 14. Results were compared with samples from age- and sex-matched healthy control subjects.

Results
Patients receiving induction therapy with IFX (n = 71) or VEDO (n = 51) and healthy control subjects (n = 50) were included. At baseline, hepcidin correlated positively with ferritin and negatively with soluble transferrin receptor/log ferritin index (P &lt; .001). ID was prevalent in 96.7% of patients who had hepcidin levels below the median. Hepcidin accurately identified ID: the area under the curve (hepcidin) was 0.89 (95% confidence interval, 0.82-0.95; P &lt; .001). In total, 75.4% of patients responded to induction therapy; inflammation, hepcidin, and ferritin decreased significantly, while transferrin increased during induction therapy. These changes were observed only in patients who responded to the therapy.

Conclusions
Hepcidin levels in IBD are primarily determined by ID, even in an inflammatory state. In addition, induction therapy can decrease hepcidin levels, which might lead to better bioavailability of iron supplements. Therefore, hepcidin is a potential diagnostic ID biomarker that could assist therapeutic decision making.
Community pharmacists’ knowledge of substandard and falsified medicines in clinical practice: a cross-sectional survey in Saudi Arabia
Authors: Bashayr Ali Alsaeed , Barrett Ravina 
Published: February 2023

AbstractAimThe main objective of this study was to explore community pharmacists’ knowledge of substandard and falsified medicines (SFs).MethodA descriptive cross-sectional study was conducted with community pharmacists in the Kingdom of Saudi Arabia using a pre-validated electronic survey.Key findingsNinety-two community pharmacists participated in this study. Many of the respondents (68.5%) had no experience with identifying SFs. We identified a concerning trend of under-reporting SFs (P &lt; 0.003). Respondents reported that SFs constitutes 1–5% of medicines, with weight loss medicines being the most targeted for falsification. Most of the respondents had a low level of awareness about the newly implemented anti-counterfeit system in Saudi Arabia called the ‘Drug Track and Trace System’ (28.3% not really, 23.1% not at all). Respondents showed low levels of knowledge about technologies available to detect SFs (P &lt; 0.01).ConclusionsCommunity pharmacists’ self-reported awareness and knowledge of SFs in Saudi Arabia was inadequate; this deficiency may affect their ability to protect their patients from potential harm by combating SFs. As a regulatory body responsible for issues related to SFs, the Saudi Food and Drug Authority should develop an action plan to equip community pharmacists with training in SFs to enhance their ability to respond to SFs.
Nichols Algebras and Quantum Principal Bundles
Authors: Krutov Andrey O , Ó Buachalla Réamonn , Strung Karen R 
Published: February 2023

AbstractWe introduce a general framework for associating to a homogeneous quantum principal bundle a Yetter–Drinfeld module structure on the cotangent space of the base calculus. The holomorphic and anti-holomorphic Heckenberger–Kolb calculi of the quantum Grassmannians are then presented in this framework. This allows us to express the calculi in terms of the corresponding Nichols algebras. The extension of this result to all irreducible quantum flag manifolds is then conjectured.
Clinical information system (CIS) implementation in developing countries: requirements, success factors, and recommendations
Authors: Tun Soe Ye Yint , Madanian Samaneh 
Published: February 2023

AbstractObjectiveClinical Information System (CIS) usage can reduce healthcare costs over time, improve the quality of medical care and safety, and enhance clinical efficiency. However, CIS implementation in developing countries poses additional, different challenges from the developed countries. Therefore, this research aimed to systematically review the literature, gathering and integrating research findings on Success Factors (SFs) in CIS implementation for developing countries. This helps to integrate past knowledge and develop a set of recommendations, presented as a framework, for implementing CIS in developing countries.Materials and MethodsA systematic literature review was conducted, followed by qualitative data analysis on the published articles related to requirements and SF for CIS implementation. Eighty-three articles met the inclusion criteria and were included in the data analysis. Thematic analysis and cross-case analysis were applied to identify and categorize the requirements and SF for CIS implementation in developing countries.ResultsSix major requirement categories were identified including project management, financial resources, government involvement and support, human resources, organizational, and technical requirements. Subcategories related to SF are classified under each major requirement. A set of recommendations is provided, presented in a framework, based on the project management lifecycle approach.ConclusionThe proposed framework could support CIS implementations in developing countries while enhancing their rate of success. Future studies should focus on identifying barriers to CIS implementation in developing countries. The country-specific empirical studies should also be conducted based on this research’s findings to match the local context.
Preoperative Breast MRI: Current Evidence and Patient Selection
Authors: Christensen Diana M , Shehata Mariam N , Javid Sara H , Rahbar Habib , Lam Diana L 
Published: February 2023

AbstractBreast MRI is the most sensitive imaging modality for the assessment of newly diagnosed breast cancer extent and can detect additional mammographically and clinically occult breast cancers in the ipsilateral and contralateral breasts. Nonetheless, appropriate use of breast MRI in the setting of newly diagnosed breast cancer remains debated. Though highly sensitive, MRI is less specific and may result in false positives and overestimation of disease when MRI findings are not biopsied prior to surgical excision. Furthermore, improved anatomic depiction of breast cancer on MRI has not consistently translated to improved clinical outcomes, such as lower rates of re-excision or breast cancer recurrence, though there is a paucity of well-designed studies examining these issues. In addition, current treatment paradigms have been developed in the absence of this more accurate depiction of disease span, which likely has limited the value of MRI. These issues have led to inconsistent and variable utilization of preoperative MRI across practice settings and providers. In this review, we discuss the history of breast MRI and its current use and recommendations with a focus on the preoperative setting. We review the evidence surrounding the use of preoperative MRI in the evaluation of breast malignancies and discuss the data on breast MRI in the setting of specific patient factors often used to determine breast MRI eligibility, such as age, index tumor phenotype, and breast density. Finally, we review the impact of breast MRI on surgical outcomes (re-excision and mastectomy rates) and long-term breast recurrence and survival outcomes.
Impact of Patient Navigation on Reducing Breast Imaging Disparities and Applications in the COVID-19 Era
Authors: Gong Anna J , Lee Emerson E , Visvanathan Kala , Oluyemi Eniola T 
Published: February 2023

Abstract
The coronavirus (COVID-19) pandemic has impacted breast cancer screening with concerns that this may lead to increased overall breast cancer mortality and worsened racial and ethnic disparities in breast cancer survival. As pandemic recovery efforts are underway, we must be prepared to address barriers to timely access of breast imaging services, including those that existed prior to the pandemic, as well as any new barriers that may arise as a result of the pandemic. Patient navigation is an important tool that has been shown to address barriers to timely breast imaging access and help reduce disparities. Patient navigation programs can serve as a key part of the strategy to mitigate the impact of the COVID-19 pandemic on timely breast cancer diagnosis. These programs have been shown to be successful in promoting adherence to breast cancer screening guidelines as well as encouraging timely diagnostic follow-up, particularly in underserved communities. Further research is needed to explore the role of using a telehealth platform for patient navigation and evaluate the cost-effectiveness of patient navigator programs as well as more randomized controlled trials to further explore the impact of patient navigation programs.
The Political Economy Consequences of China’s Export Slowdown
Authors: Campante Filipe R , Chor Davin , Li Bingjing 
Published: February 2023

Abstract
We study how adverse economic shocks influence political outcomes in strong authoritarian regimes, by examining the export slowdown in China during the mid-2010s. We first show that prefectures that experienced a more severe export slowdown witnessed a significant increase in incidents of labor strikes, using a shift-share instrumental variables strategy. The prefecture party secretary was subsequently more likely to be replaced by the central government, particularly if the rise in strikes was greater than in other prefectures that saw comparable export slowdowns. These patterns are consistent with a simple framework we develop, where the central government makes strategic use of a turnover decision to induce effort from local officials in preserving social stability, and to screen them for retention. In line with the framework’s predictions, we find a heightened emphasis by local party secretaries—particularly younger officials whose career concerns are stronger—on upholding stability following negative export shocks. This is evident in both words (from textual analysis of official speeches) and deeds (from expenditures on public security and social spending).
Accessory After the Fact at the International Criminal Court?
Authors: Ventura Manuel J 
Published: February 2023

Abstract
It has generally been understood that international criminal law recognizes ex post facto aiding and abetting as a mode of liability but not the standalone offence commonly known, in many states, as accessory after the fact. However, as this article reveals, the authentic Spanish text of Article 25(3)(c) of the Rome Statute of the International Criminal Court (‘ICC Statute’) includes the word ‘encubridor’ which — as a comparative analysis of the Criminal Codes of Spanish-speaking countries confirms — is the Spanish language legal equivalent of a person that is an accessory after the fact. Yet, nothing in the authentic English text of Article 25(3)(c) — the version that most of the international criminal law scholarship and the International Criminal Court (‘ICC’) have focused on — alludes to this. To resolve this substantive discrepancy, Article 25(3)(c) is considered across all authentic languages (Arabic, Chinese, English, French, Russian, and Spanish) and in light of Articles 31–33 of the 1969 Vienna Convention on the Law of Treaties in a manner consistent with the rights of the accused. This article concludes that the mentioned discrepancy is unique to Article 25(3)(c) in the authentic Spanish language, most likely the result of an error, and that the concept of ‘accessory after the fact’ should not be applied at the ICC. That Article 25(3), a provision that has featured in so many ICC decisions and judgments and spawned so much academic writing, has contained such a glaring and seemingly undetected error for over 24 years ought to compel commentators, academics, and practitioners to look beyond the working languages of the ICC — English and French — when analysing, interpreting, and applying the ICC Statute.
Modal structures in groups and vector spaces
Authors: van Benthem Johan , Bezhanishvili Nick 
Published: February 2023

Abstract
Vector spaces contain a number of general structures that invite analysis in modal languages. The resulting logical systems provide an interesting counterpart to the much better-studied modal logics of topological spaces. In this programmatic paper, we investigate issues of definability and axiomatization using standard techniques for modal and hybrid languages. The analysis proceeds in stages. We first present a modal analysis of commutative groups that establishes our main techniques, next we introduce a new modal logic of linear dependence and independence in vector spaces and, finally, we study a modal logic for describing full-fledged vector spaces. While still far from covering every basic aspect of linear algebra, our discussion identifies several leads for more systematic research.
Clinical and imaging characteristics of pulmonary cryptococcosis: a comparative analysis of 118 non-AIDS patients in China
Authors: Xiong Ping , Huang Chaowen , Zhong Liandi , Huang Liebin 
Published: February 2023

AbstractThe accurate diagnosis of pulmonary cryptococcosis (PC) is an important guarantee for the selection of reasonable treatment methods. In this paper, the clinical and imaging manifestations of PC in non-AIDS patients were retrospectively analyzed, and according to whether there was an underlying disease, a comparative analysis was carried out to deepen the understanding of PC, and improve the accuracy of its diagnosis. Both clinical and CT imaging data of 118 PC patients were analyzed retrospectively. The clinical manifestations of PC patients were not specific, and 61 patients had no apparent symptoms. A total of 49 patients (49/118) were treated with antifungal agents alone, 46 of them had follow-up records after treatment, and 91.3% (42/46) of them achieved a good outcome. The most common imaging sign was the subpleural nodule or mass. Other main imaging signs include bronchial air sign (50/118), halo sign (32/118), ring target sign (65/118), lobulation sign (72/118), and necrosis (76/118). In terms of age, halo sign, and ring target sign, there were significant differences between the group with underlying disease and the group without underlying disease (P &lt; .05). The CT manifestations of PC have some characteristics, and using antifungal agents can achieve good outcomes.
Binary asteroid scattering around white dwarfs
Authors: McDonald Catriona H , Veras Dimitri 
Published: February 2023

ABSTRACTIncreasing observations of white dwarf atmospheric pollution and disrupting planetesimals is driving increased studies into the fate of exo-asteroids around post-main-sequence stars. Planetesimal populations in the Solar System that are most likely to survive the violent post-main-sequence evolution, such as the Kuiper Belt, display a large binary fraction with a propensity for near equal-mass components and provide a previously unexplored population of planetesimals that are likely to exist around white dwarfs. Here, we simulate the dynamical evolution of equal-mass binary asteroid systems around white dwarfs using the N-body integrator REBOUND for 1 Gyr. We confirm that giant planets are efficient at dissociating and ejecting binary asteroid systems on eccentric orbits, while Earth-mass planets are better at keeping planetesimals in their planetary systems. We find binary systems can be dissociated and ejected from their systems across Myr time-scales, producing interstellar objects. We do not expect a population of free-floating binary asteroid systems as all ejected planetesimals are gravitationally unbound from each other. Further, we discuss the influence of asteroid binarity on the white dwarf pollution process and find there is little to no impact on how close a body can get to a star. However, the orbital evolution of binary asteroids changes the distribution of planetesimals available in a white dwarf planetary system to be further scattered onto white dwarf polluting orbits.
Inferring neutron star properties with continuous gravitational waves
Authors: Lu Neil , Wette Karl , Scott Susan M , Melatos Andrew 
Published: February 2023

ABSTRACT
Detection of continuous gravitational waves from rapidly spinning neutron stars opens up the possibility of examining their internal physics. We develop a framework that leverages a future continuous gravitational wave detection to infer a neutron star’s moment of inertia, equatorial ellipticity, and the component of the magnetic dipole moment perpendicular to its rotation axis. We assume that the neutron star loses rotational kinetic energy through both gravitational wave and electromagnetic radiation, and that the distance to the neutron star can be measured, but do not assume electromagnetic pulsations are observable or a particular neutron star equation of state. We use the Fisher information matrix and Monte Carlo simulations to estimate errors in the inferred parameters, assuming a population of gravitational-wave-emitting neutron stars consistent with the typical parameter domains of continuous gravitational wave searches. After an observation time of 1 yr, the inferred errors for many neutron stars are limited chiefly by the error in the distance to the star. The techniques developed here will be useful if continuous gravitational waves are detected from a radio, X-ray, or gamma-ray pulsar, or else from a compact object with known distance, such as a supernova remnant.
The ALMOND survey: molecular cloud properties and gas density tracers across 25 nearby spiral galaxies with ALMA
Authors: Neumann Lukas , Gallagher Molly J , Bigiel Frank , Leroy Adam K , Barnes Ashley T , Usero Antonio , den Brok Jakob S , Belfiore Francesco , Bešlić Ivana , Cao Yixian , Chevance Mélanie , Dale Daniel A , Eibensteiner Cosima , Glover Simon C O , Grasha Kathryn , Henshaw Jonathan D , Jiménez-Donaire María J , Klessen Ralf S , Kruijssen J M Diederik , Liu Daizhong , Meidt Sharon , Pety Jérôme , Puschnig Johannes , Querejeta Miguel , Rosolowsky Erik , Schinnerer Eva , Schruba Andreas , Sormani Mattia C , Sun Jiayi , Teng Yu-Hsuan , Williams Thomas G 
Published: February 2023

ABSTRACT
We use new HCN(1–0) data from the ACA Large-sample Mapping Of Nearby galaxies in Dense gas (ALMOND) survey to trace the kpc-scale molecular gas density structure and CO(2–1) data from the Physics at High Angular resolution in Nearby GalaxieS–Atacama Large Millimeter/submillimeter Array (PHANGS–ALMA) to trace the bulk molecular gas across 25 nearby star-forming galaxies. At 2.1 kpc scale, we measure the density-sensitive HCN/CO line ratio and the star formation rate (SFR)/HCN ratio to trace the star formation efficiency in the denser molecular medium. At 150 pc scale, we measure structural and dynamical properties of the molecular gas via CO(2–1) line emission, which is linked to the lower resolution data using an intensity-weighted averaging method. We find positive correlations (negative) of HCN/CO (SFR/HCN) with the surface density, the velocity dispersion, and the internal turbulent pressure of the molecular gas. These observed correlations agree with expected trends from turbulent models of star formation, which consider a single free-fall time gravitational collapse. Our results show that the kpc-scale HCN/CO line ratio is a powerful tool to trace the 150 pc scale average density distribution of the molecular clouds. Lastly, we find systematic variations of the SFR/HCN ratio with cloud-scale molecular gas properties, which are incompatible with a universal star formation efficiency. Overall, these findings show that mean molecular gas density, molecular cloud properties, and star formation are closely linked in a coherent way, and observations of density-sensitive molecular gas tracers are a useful tool to analyse these variations, linking molecular gas physics to stellar output across galaxy discs.
Supernova connection of unidentified ultra-high-energy gamma-ray source LHAASO J2108+5157
Authors: De Sarkar Agnibha 
Published: February 2023

ABSTRACT
We present a simple phenomenological model of hadronic interaction between protons accelerated in an old supernova remnant (SNR) and cold protons situated within the associated molecular clouds (MCs). The accelerated protons from the old SNR escaped the SNR shock front, and got injected into the MCs at an earlier time, producing ultra-high-energy gamma-rays and neutrinos through inelastic proton–proton interaction. We also take into account the acceleration and subsequent escape of electrons from the SNR shock front. The escaped electrons produce gamma-rays through various radiative cooling mechanisms, after getting injected into the MCs. We use the model discussed in this letter to explain the multiwavelength spectral energy distribution of unidentified Galactic ultra-high-energy gamma-ray source LHAASO J2108+5157. We also discuss the feasibility of applying this model in other cases as well. Future observations can test the viability of the model discussed in this letter, which will in turn confirm that the SNRs can, in fact, accelerate particles up to PeV energies.