bluuebunny/crossref_metadata_2025_split huggingface dataset:
Behavioural Insights and Public Policy in Canada
Authors: Hopkins Vincent , Lawlor Andrea 
Published: April 2023

AbstractMuch of political science rests on assumptions about how policy makers and citizens behave. However, questions remain about how public policy can improve the government–citizen relationship. In this research note, we present behavioural insights (BI) as one way to address this gap. First, we argue that BI can be strategically used both to alleviate administrative burdens and to enhance citizen experience. Second, we argue that BI interventions can assist in several stages of the policy process, strengthening causal inferences about policy efficacy. Third, we present original data from Canada's ongoing experimentation with BI across multiple jurisdictions and areas of public policy. We conclude by acknowledging the myriad pathways through which BI research can engage with public policy to support the enhancement of citizen-oriented service delivery.
SENSE AND SEPARABILITY
Authors: Camilleri Simon 
Published: April 2023

AbstractThis article explores the doctrine of separability, as understood in particular in the English legal tradition. It does so by reference to the decisions in Sulamérica Cia Nacional de Seguros SA and others v Enesa Engelharia SA and others and ENKA İnşaat ve Sanayi A.Ş. v OOO ‘Insurance Company Chubb’ & Ors that explore the relevance of the concept when determining the law applicable to the arbitration agreement. These decisions largely treat the doctrine as irrelevant to the determination of the law governing the arbitration agreement. They do so because of the way in which English law views separability as tied inimically to the concept of enforcement of the arbitration agreement. This is unsurprising given the content of section 7 of the Arbitration Act 1996 and the position of the doctrine of separability as a legal fiction that must be restricted to its defined purpose. Viewed against the potential reform of the Arbitration Act 1996, the author asks whether a broader view of separability can be adopted. The author's view is that there are cogent and compelling reasons for adopting a broader view, that would promote certainty and consistency in a way that is not best served by the current approach.
Effectiveness of near-UVA in SARS-CoV-2 inactivation
Authors: Frilli Eleonora , Amodeo Davide , Cevenini Gabriele , Nante Nicola , Messina Gabriele 
Published: April 2023

Abstract
This experimental study aimed to determine the activity of a near-UVA (405 nm) LED ceiling system against the SARS-CoV-2 virus. The ceiling system comprised 17 near-UVA LED lights with a radiant power of 1.1 W/each centred at 405 nm wavelength. A 96-multiwell plate, fixed to a wooden base, was inoculated with suspensions of VERO E6 cell cultures infected with SARS-CoV-2 virus and irradiated at a distance of 40 cm with a dose of 20.2 J/cm2 for 120 min. The collected suspensions were transferred to VERO cell culture plates and incubated for 3 days. The maximum measurable log reduction obtained, starting from a concentration of 107.2 TCID50/mL, was 3.0 log10 and indicated inhibition of SARS-CoV-2 replication by the near-UVA LED ceiling system. Near-UVA light at a 405-nm wavelength is emerging as a potential alternative treatment for localised infections and environmental decontamination because it is far less harmful to living organisms’ cells than UV-C irradiation.
Six-month cardiac outcomes in children with multisystem inflammatory syndrome in children
Authors: Kaltman Joshua , Keesari Rohali , Madani Rohit , Jaggi Preeti , Oster Matthew E. 
Published: April 2023

AbstractBackground:Multisystem inflammatory syndrome in children is a rare, post-infectious complication of SARS-CoV-2 infection in children. We aimed to assess the long-term sequelae, particularly cardiac, in a large, diverse population.Methods:We performed a retrospective cohort study of all children (aged 0–20 years, n = 304) admitted to a tertiary care centre with a diagnosis of multisystem inflammatory syndrome in children from March 1, 2020 to August 31, 2021 and had at least one follow-up visit through December 31, 2021. Data were collected at hospitalisation, 2 weeks, 6 weeks, 3 months, and 1 year after diagnosis, where applicable. Cardiovascular outcomes included left ventricular ejection fraction, presence or absence of pericardial effusion, coronary artery abnormalities, and abnormal electrocardiogram findings.Results:Population was median age 9 years (IQR 5–12), 62.2% male, 61.8% African American (AA), and 15.8% Hispanic. Hospitalisation findings included abnormal echocardiogram 57.2%, mean worst recorded left ventricular ejection fraction 52.4% ± 12.4%, non-trivial pericardial effusion 13.4%, coronary artery abnormalities 10.6%, and abnormal ECG 19.6%. During follow-up, abnormal echocardiogram significantly decreased to 6.0% at 2 weeks and 4.7% at 6 weeks. Mean left ventricular ejection fraction significantly increased to 65.4% ± 5.6% at 2 weeks and stabilised. Pericardial effusion significantly decreased to 3.2% at 2 weeks and stabilised. Coronary artery abnormalities significantly decreased to 2.0% and abnormal electrocardiograms significantly decreased to 6.4% at 2 weeks and stabilised.Conclusion:Children with multisystem inflammatory syndrome in children have significant echocardiographic abnormalities during the acute presentation, but these findings typically improve within weeks. However, a small subset of patients may have persistent coronary abnormalities.
Idiopathic dilatation of the right atrium: a case report
Authors: Almeida Catarina Maria , Sarmento João Antunes , Miranda Joana O. 
Published: April 2023

AbstractIdiopathic dilatation of the right atrium is a rare congenital anomaly that presents as an isolated enlargement of the right atrium. Thrombus formation and atrial arrhythmias are the major complications and management with antiplatelet therapy is recommended. Reduction atrial plasty is reserved for specific patients. We report a case of idiopathic dilatation of the right atrium diagnosed prenatally with a 10-year follow-up.
The impact of caring on caregivers of patients with life-threatening organ failure
Authors: Kurita Geana Paula , Eidemak Inge , Larsen Sille , Jeppesen Palle Bekker , Antonsen Louise Bangsgaard , Molsted Stig , Liem Ylian Serina , Pressler Tania , Sjøgren Per 
Published: April 2023

AbstractObjectivesThis study aimed at characterizing 3 populations of family/friend caregivers of patients with different life-threatening organ failure regarding health-related quality of life, caregiver burden, and dyadic coping.MethodsThree cross-sectional (population) studies were conducted at a tertiary hospital in Denmark (2019–2020). Patients with renal failure (RF), cystic fibrosis (CF), and intestinal failure (IF) were asked to designate the closest person with ≥18 years old involved in the care (caregiver) to participate in this study. Number of caregivers included were RF = 78, CF = 104, and IF = 73. Electronic questionnaires were filled in by caregivers to assess health-related quality of life and caregiver burden and by caregivers and respective patients to assess dyadic coping.ResultsThe 3 caregiver groups had self-perception of poor health and energy; however, caregivers of CF patients perceived their physical role functioning better than those caregiving for RF and IF patients (p = 0.002). The level of caregiver burden was reported as not high, but caregivers used in average 13 hours/day for caring. Moreover, cleaning tasks (p = 0.005) and personal care (p = 0.009) were more demanding in RF and IF patients. Caregivers also did not differ regarding dyadic coping. When comparing patients and caregivers, stress communication by oneself and the partner differed (p < 0.001).Significance of resultsCaregivers spent many hours in the care role, they reported poor health, and dyadic coping may be improved. Interventions in caregivers of patients with life-threatening organ failure could help to improve care management at home, caregiver’s health, and dyadic coping between caregiver and patient and consequently reduce caregiver burden.
Target-site and non–target site mechanisms of pronamide resistance in annual bluegrass (Poa annua) populations from Mississippi golf courses
Authors: Ignes Martin , McCurdy James D. , McElroy J. Scott , Castro Edicarlos B. , Ferguson Jason C. , Meredith Ashley N. , Rutland Claudia Ann , Stewart Barry R. , Tseng Te-Ming P. 
Published: April 2023

AbstractThe mitotic-inhibiting herbicide pronamide controls susceptible annual bluegrass (Poa annua L.) pre- and postemergence, but in some resistant populations, postemergence activity is compromised, hypothetically due to a target-site mutation, lack of root uptake, or an unknown resistance mechanism. Three suspected pronamide-resistant (LH-R, SC-R, and SL-R) and two pronamide-susceptible (BS-S and HH-S) populations were collected from Mississippi golf courses. Dose–response experiments were conducted to confirm and quantify pronamide resistance, as well as resistance to flazasulfuron and simazine. Target sites known to confer resistance to mitotic-inhibiting herbicides were sequenced, as were target sites for herbicides inhibiting acetolactate synthase (ALS) and photosystem II (PSII). Pronamide absorption and translocation were investigated following foliar and soil applications. Dose–response experiments confirmed pronamide resistance of LH-R, SC-R, and SL-R populations, as well as instances of multiple resistance to ALS- and PSII-inhibiting herbicides. Sequencing of the α-tubulin gene confirmed the presence of a mutation that substituted isoleucine for threonine at position 239 (Thr-239-Ile) in LH-R, SC-R, SL-R, and BS-S populations. Foliar application experiments failed to identify differences in pronamide absorption and translocation between the five populations, regardless of harvest time. All populations had limited basipetal translocation—only 3% to 13% of the absorbed pronamide—across harvest times. Soil application experiments revealed that pronamide translocation was similar between SC-R, SL-R, and both susceptible populations across harvest times. The LH-R population translocated less soil-applied pronamide than susceptible populations at 24, 72, and 168 h after treatment, suggesting that reduced acropetal translocation may contribute to pronamide resistance. This study reports three new pronamide-resistant populations, two of which are resistant to two modes of action (MOAs), and one of which is resistant to three MOAs. Results suggest that both target site– and translocation-based mechanisms may be associated with pronamide resistance. Further research is needed to confirm the link between pronamide resistance and the Thr-239-Ile mutation of the α-tubulin gene.
Dicamba air concentrations in eastern Arkansas and impact on soybean
Authors: Zaccaro-Gruener Maria Leticia , Norsworthy Jason K. , Brabham Chad B. , Barber L. Tom , Roberts Trenton L. , Mauromoustakos Andy , Mueller Thomas C. 
Published: April 2023

AbstractDamage to non–dicamba resistant (non-DR) soybean [Glycine max (L.) Merr.] has been frequent in geographies where dicamba-resistant (DR) soybean and cotton (Gossypium hirsutum L.) have been grown and sprayed with the herbicide in recent years. Off-target movement field trials were conducted in northwest Arkansas to determine the relationship between dicamba concentration in the air and the extent of symptomology on non-DR soybean. Additionally, the frequency and concentration of dicamba in air samples at two locations in eastern Arkansas and environmental conditions that impacted the detection of the herbicide in air samples were evaluated. Treatment applications included dicamba at 560 g ae ha−1 (1X rate), glyphosate at 860 g ae ha−1, and particle drift retardant at 1% v/v applied to 0.37-ha fields with varying degrees of vegetation. The relationship between dicamba concentration in air samples and non-DR soybean response to the herbicide was more predictive with visible injury (generalized R2 = 0.82) than height reduction (generalized R2 = 0.43). The predicted dicamba air concentration resulting in 10% injury to soybean was 1.60 ng m−3 d−1 for a single exposure. The predicted concentration from a single exposure to dicamba resulting in a 10% height reduction was 3.78 ng m−3 d−1. Dicamba was frequently detected in eastern Arkansas, and daily detections above 1.60 ng m−3 occurred 17 times in the period sampled. The maximum concentration of dicamba recorded was 7.96 ng m−3 d−1, while dicamba concentrations at Marianna and Keiser, AR, were ≥1 ng m−3 d−1 in six samples collected in 2020 and 22 samples in 2021. Dicamba was detected consistently in air samples collected, indicating high usage in the region and the potential for soybean damage over an extended period. More research is needed to quantify the plant absorption rate of volatile dicamba and to evaluate the impact of multiple exposures of gaseous dicamba on non-targeted plant species.
Decadal Predictability of the North Atlantic Eddy‐Driven Jet in Winter
Authors: Marcheggiani Andrea , Robson Jon , Monerie Paul‐Arthur , Bracegirdle Thomas J. , Smith Doug 
Published: April 2023

AbstractThis paper expands on work showing that the winter North Atlantic Oscillation (NAO) is predictable on decadal timescales to quantify the skill in capturing the North Atlantic eddy‐driven jet's location and speed. By focusing on decadal predictions made for years 2–9 from the sixth Coupled Model Intercomparison Project over 1960–2005 we find that there is significant skill in jet latitude and, especially, jet speed associated with the skill in the NAO. However, the skill in the NAO, jet latitude and speed indices appears to be sensitive to the period over which it is assessed. In particular, skill drops considerably when evaluating hindcasts up to the present day as models fail to capture the recent observed northern shift and strengthening of the winter eddy‐driven jet, and more thus positive NAO. We suggest that the drop in atmospheric circulation skill is related to reduced skill in North Atlantic sea surface temperatures.
Unprecedented Observation of Hourly Rock Glacier Velocity With Ground‐Based SAR
Authors: Bertone Aldo , Seppi Roberto , Callegari Mattia , Cuozzo Giovanni , Dematteis Niccolò , Krainer Karl , Marin Carlo , Notarnicola Claudia , Zucca Francesco 
Published: April 2023

AbstractThe kinematic acceleration of rock glaciers observed in recent decades shows that the behavior of these landforms is related to climate change. Velocity variations on yearly to seasonal time scales are frequently investigated, but velocity changes measured on shorter time scales (i.e., on hourly resolutions) are as yet poorly investigated. We used a ground based synthetic aperture radar to investigate, on an hourly time scale, the displacement of a rock glacier located in Val Senales (European Alps, northern Italy). We observed velocity fluctuations occurring at a very regular pace, characterized by phases of sharp acceleration (up to 0.9 mm/hr) lasting 4–11 hr followed by long phases of stagnation lasting 13–20 hr. This study describes an unprecedented observation of an hourly velocity rhythm of an active rock glacier and opens up new perspectives in the analysis and interpretation of rock glacier kinematics.
Lithospheric Elastic Thickness Beneath the Caloris Basin: Implications for the Thermal Structure of Mercury
Authors: Deng Qingyun , Xiao Zhiyong , Zhong Zhen , Ye Mao , Li Fei , Yan Jianguo , Barriot Jean‐Pierre 
Published: April 2023

AbstractThe elastic thickness of a planet's lithosphere is essential to the investigation of its thermal evolution. Our work focuses on the largest visible impact basin on Mercury, Caloris, which has undergone complex magma‐tectonic deformation after its formation. Using a flexural lithosphere model with the initial mantle plug loading, we estimated the elastic thickness in the Caloris region to be 18.0 4.4 km. The successful application of the mantle loading model and the small load ratio indicates that major load in the Caloris region is the mantle plug rather than the lateral density anomaly. The 18 km effective elastic thickness indicates the lithospheric temperature at the time of loading. The current heat production rate in Mercury mantle is estimated as 2.2–4.2 × 10−12 W/kg. Comparison between the effective elastic thickness predicted from the thermal model and loading model suggests that the megaregolith in the Caloris basin region has a certain thickness (>3 km) to ensure the formation of a lithosphere with 18 km elastic thickness. The temperature model results also indicate that the mantle heat production rate at 3.6 Ga is closer to that calculated based on a model with heat‐producing elements abundance close to CI chondrite‐like primitive silicate portion of Mercury. The surface heat flow in the Caloris region is consistent with other megaregolith‐covered regions.
A deep neural network regressor for phase constitution estimation in the high entropy alloy system Al-Co-Cr-Fe-Mn-Nb-Ni
Authors: Vazquez G. , Chakravarty S. , Gurrola R. , Arróyave R. 
Published: April 2023

AbstractHigh Entropy Alloys (HEAs) are composed of more than one principal element and constitute a major paradigm in metals research. The HEA space is vast and an exhaustive exploration is improbable. Therefore, a thorough estimation of the phases present in the HEA is of paramount importance for alloy design. Machine Learning presents a feasible and non-expensive method for predicting possible new HEAs on-the-fly. A deep neural network (DNN) model for the elemental system of: Mn, Ni, Fe, Al, Cr, Nb, and Co is developed using a dataset generated by high-throughput computational thermodynamic calculations using Thermo-Calc. The features list used for the neural network is developed based on literature and freely available databases. A feature significance analysis matches the reported HEAs phase constitution trends on elemental properties and further expands it by providing so far-overlooked features. The final regressor has a coefficient of determination (r2) greater than 0.96 for identifying the most recurrent phases and the functionality is tested by running optimization tasks that simulate those required in alloy design. The DNN developed constitutes an example of an emulator that can be used in fast, real-time materials discovery/design tasks.
Local genetic correlations exist among neurodegenerative and neuropsychiatric diseases
Authors: Reynolds Regina H. , Wagen Aaron Z. , Lona-Durazo Frida , Scholz Sonja W. , Shoai Maryam , Hardy John , Gagliano Taliun Sarah A. , Ryten Mina 
Published: April 2023

AbstractGenetic correlation ($$r_g$$rg) between traits can offer valuable insight into underlying shared biological mechanisms. Neurodegenerative diseases overlap neuropathologically and often manifest comorbid neuropsychiatric symptoms. However, global$$r_g$$rganalyses show minimal$$r_g$$rgamong neurodegenerative and neuropsychiatric diseases. Importantly, local$$r_g$$rgs can exist in the absence of global relationships. To investigate this possibility, we applied LAVA, a tool for local$$r_g$$rganalysis, to genome-wide association studies of 3 neurodegenerative diseases (Alzheimer’s disease, Lewy body dementia and Parkinson’s disease) and 3 neuropsychiatric disorders (bipolar disorder, major depressive disorder and schizophrenia). We identified several local$$r_g$$rgs missed in global analyses, including between (i) all 3 neurodegenerative diseases and schizophrenia and (ii) Alzheimer’s and Parkinson’s disease. For those local$$r_g$$rgs identified in genomic regions containing disease-implicated genes, such asSNCA, CLUandAPOE, incorporation of expression quantitative trait loci identified genes that may drive genetic overlaps between diseases. Collectively, we demonstrate that complex genetic relationships exist among neurodegenerative and neuropsychiatric diseases, highlighting putative pleiotropic genomic regions and genes. These findings imply sharing of pathogenic processes and the potential existence of common therapeutic targets.
Programmable photonic integrated meshes for modular generation of optical entanglement links
Authors: Dong Mark , Zimmermann Matthew , Heim David , Choi Hyeongrak , Clark Genevieve , Leenheer Andrew J. , Palm Kevin J. , Witte Alex , Dominguez Daniel , Gilbert Gerald , Eichenfield Matt , Englund Dirk 
Published: April 2023

AbstractLarge-scale generation of quantum entanglement between individually controllable qubits is at the core of quantum computing, communications, and sensing. Modular architectures of remotely-connected quantum technologies have been proposed for a variety of physical qubits, with demonstrations reported in atomic and all-photonic systems. However, an open challenge in these architectures lies in constructing high-speed and high-fidelity reconfigurable photonic networks for optically-heralded entanglement among target qubits. Here we introduce a programmable photonic integrated circuit (PIC), realized in a piezo-actuated silicon nitride (SiN)-in-oxide CMOS-compatible process, that implements an N × N Mach–Zehnder mesh (MZM) capable of high-speed execution of linear optical transformations. The visible-spectrum photonic integrated mesh is programmed to generate optical connectivity on up to N = 8 inputs for a range of optically-heralded entanglement protocols. In particular, we experimentally demonstrated optical connections between 16 independent pairwise mode couplings through the MZM, with optical transformation fidelities averaging 0.991 ± 0.0063. The PIC’s reconfigurable optical connectivity suffices for the production of 8-qubit resource states as building blocks of larger topological cluster states for quantum computing. Our programmable PIC platform enables the fast and scalable optical switching technology necessary for network-based quantum information processors.
What are the barriers and facilitators of clozapine use in early psychosis? A survey of UK early intervention clinicians
Authors: Oloyede Ebenezer , Blackman Graham , Mantell Bethany , Harris Eleanor , Williams Julie , Taylor David , MacCabe James , McGuire Philip 
Published: April 2023

AbstractClozapine is the most effective medication for treatment-resistant psychosis, but evidence points to substantial underuse, especially within early intervention psychosis (EIP) services. We explored clinicians’ views on perceived barriers and facilitators to offering patients clozapine within EIP services. A cross-sectional survey was distributed electronically to clinicians practising in EIP services across England. A mixed methods approach was used to assess barriers to clozapine, and attitudes and opinions concerning clozapine underutilisation. Based on the barriers identified in the literature, clinicians were asked to rate each one (scale:1-7) based on importance, with a higher score indicating higher importance. Clinicians were also asked open-ended questions on barriers to clozapine and how access can be improved in EIP services. Quantitative data were analysed using descriptive and inferential statistics, and qualitative responses were analysed thematically. One hundred and nineteen EIP clinicians from 35 services in England completed the survey. In total, 37% (n = 45) of clinicians perceived that clozapine was under-prescribed in their EIP service. The most important barrier to utilising clozapine were patient concerns with side effects, followed by monitoring requirements and clinician concerns with side effects. Thematic analysis identified 17 perceived barriers, which were grouped into three major themes: administrative (5 subthemes), clinician-related (6 subthemes), and patient-related (6 subthemes). Perceived facilitators to improving clozapine use were greater training, improved resources, and optimised monitoring. The main barriers to clozapine in EIP services, as identified by clinicians, are patient concerns regarding side effects and monitoring requirements. Identified facilitators for improved clozapine use include clinician training, improved resources, guidelines, and point-of-care testing.