bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of messaging on views of depression treatment options: Examining credibility and expectations
Authors: Gonzalez August R. , Strunk Daniel R. 
Published: June 2023

AbstractObjectiveUnderstanding how people respond to information about treatment options is important for informing efforts that promote treatment initiation and adherence. We examined the impact of informational treatment videos on treatment naive participants' views regarding the credibility of and their expectations for three treatment options.Materials and MethodsAdults (N = 300) who had experienced elevated depressive symptoms but had not participated in a treatment for depression were randomly assigned to one of four conditions. Three of the conditions were shown videos, providing information about (1) cognitive behavioral therapy (CBT), (2) antidepressant medication (ADM), or (3) the combination of CBT and ADM. The fourth condition was not shown a video. Participants' self‐reported views of the credibility of and expectations for treatment served as primary outcome variables.ResultsCompared with the control condition, videos about active treatments enhanced credibility and expectations for those treatments. When comparing CBT and ADM alone, messaging about either treatment enhanced credibility of and expectations for that treatment. The CBT only video produced the most positive expectations and highest credibility for CBT. Likewise, the ADM only video led to the most positive expectations and credibility for ADM. The video focused on combined treatment did not lead to particularly positive views of the combined treatment option.ConclusionThese findings demonstrate the importance of providing focused messaging to enhance the credibility of and expectations for treatment. Future research is needed to examine the impact of messaging in different contexts, as well as the impact of such messaging on treatment seeking, adherence, and outcomes.
Eco‐efficiency improvements in the propylene‐to‐epichlorohydrin process
Authors: Madej Łukasz , Kiss Anton A 
Published: June 2023

AbstractBACKGROUNDEpichlorohydrin (ECH) production is an important industrial process, owing to its importance in windmill blade manufacture, but it suffers from several drawbacks such as high energy use, large wastewater production and low atom efficiency. This original study investigates a novel chlorohydrin‐free technology with an enhanced separation system for ECH production. Rigorous process simulations were performed in Aspen Plus for the classic and novel processes, and a fair techno‐economic and sustainability comparison was made between the new catalytic oxidation route and the classic chlorohydrin process.RESULTSFor the hydrogen peroxide (HP) process route, a novel separation system was developed using methanol as solvent, which enables high purity of ECH. Moreover, allyl chloride (ACH) purification was optimized using thermally coupled distillation to improve the energy efficiency of ACH production. The novel HP process provides 88% higher atom efficiency, about 10% higher yield and a smaller amount of by‐products, as well as a 13% increase in production capacity and major savings of 98% in wastewater production, while also achieving lower energy use (<40 MJ kg−1 ECH) and reduced carbon dioxide emission (1.13 kg kg−1 ECH).CONCLUSIONThe developed HP process route is feasible and economically viable. Also, it can be partly retrofitted to existing ECH plants based on the chlorohydrin route. As both processes use the same intermediate product, only the ECH part of a classic process would be replaced by the novel route, while keeping the common ACH part. This approach is the most profitable, as only 55% of capital expenditure is required for this modification, while the plant would benefit from all the improvements provided by the novel process. © 2023 The Authors. Journal of Chemical Technology and Biotechnology published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry (SCI).
Development of the prognostic value in lung adenocarcinoma based on anoikis‐related genes and initial experimental validation
Authors: Guo Wenwei , Zhao Guang , Liu Suping , Deng Tao , Zhang Guangjian , Zhang Boxiang 
Published: June 2023

AbstractBackgroundLung adenocarcinoma (LUAD) is a highly aggressive cancer in advanced stages and has the highest cancer‐related death across the world. Anoikis has emerged as a specific form of apoptotic cell death that may play a vital role in the formation and development of tumors.MethodsBased on The Cancer Genome Atlas dataset, we developed a novel anoikis‐related genes (ARGs) signature in LUAD and evaluated the differences between low and high‐risk groups in clinical characteristics, expression patterns, immune cell infiltration, and drug sensitivity, etc. According to multivariate Cox regression analysis, the risk score was identified as a significant independent prognostic factor. The possible biological pathways of ARGs' were assessed by Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analyses. The immune infiltration landscape and risk score of ARGs were analyzed by ESTIMATE and CIBERSORT analysis. A nomogram grounded on six key ARGs and clinicopathological features was provided. Moreover, experiment validation of the expression patterns of six hub ARGs in lung cancer cell lines was conducted.ResultsWe identified 53 survival‐related LUAD anoikis‐related differentially expressed genes and finally six hub anoikis genes (LDHA, SLC2A1, SERPINB5, ITGB4, BRCA2, and PIK3R1) were selected to construct an ARG model. The risk model could efficiently cluster the patients into low‐ and high‐risk groups which could accurately predict clinical outcomes for LUAD patients. There is evidence that the prognostic risk score is a remarkable prognostic factor in determining overall survival. Different immune statuses and drug sensitivity between low‐ and high‐risk groups were explored according to functional analysis. On the basis of risk scores and LUAD clinicopathological features, a novel nomogram was developed. Ultimately, all six key genes except for PIK3R1 were proved to be upregulated in LUAD tissues and cell lines by bioinformatics analysis and experimental validation.ConclusionsThe result of the present study suggest that ARGs could be carcinogenic to LUAD and could be used as an effective stratification factor to customize therapies and forecast the survival rate in LUAD patients.
用手圧迫止血法による体外式膜型人工心肺のカニューレ抜去と仮性動脈瘤形成に関する検討(Pseudoaneurysm formation after percutaneous decannulation of venoarterial extracorporeal membrane oxygenation with manual compression)
Authors: 正樹 高橋 , 就 田原 , 峰司 早川 
Published: June 2023

要旨【目的】Venoarterial extracorporeal membrane oxygenation（VA–ECMO）の送血カニューレ抜去時に用手圧迫で止血を行った場合の，仮性動脈瘤が形成される頻度を調査した。【対象】2000年6月から2019年12月の間に当院に救急搬送され，入院中にVA–ECMOを導入した18歳以上の患者を対象とし，後方視的に検討を行った。ECMO導入中もしくは離脱後24時間以内に転院・死亡した患者，手術中のみECMOを使用した患者，カニューレ抜去時に外科的血管縫合術を行った患者は除外した。対象患者のカルテ情報を基に，VA–ECMO離脱後の仮性動脈瘤形成の有無を評価し，その頻度を調査した。また，仮性動脈瘤の形成群と非形成群に分け，患者背景，カニューレ径，ECMO導入期間，体外循環式心肺蘇生の割合を比較した。仮性動脈瘤形成例に対しては，その後に要した処置を調査した。【結果】142例が解析対象となり，そのうち6例（4.2%）にVA–ECMO離脱後の仮性動脈瘤形成がみられた。6例中4例は用手圧迫により仮性動脈瘤が消失し，1例は外科的血管修復術を要した。動脈瘤形成群と非形成群の間で，収集項目の統計学的有意差はみられなかった。【結語】当院において，VA–ECMOのカニューレ抜去時に用手圧迫で止血した場合，その後の仮性動脈瘤形成頻度は4.2%であった。
Edoxaban treatment in atrial fibrillation in routine clinical care: One‐year outcomes of the prospective observational ETNA‐AF study in South Korean patients
Authors: Choi Eue‐Keun , Choi Jong‐Il , Park Hyoung‐Seob , Hwang Gyo‐Seung , Joung Boyoung , Kim Jong‐Youn , Kim Dae‐Hyeok , Shin Dong Gu , Park Hyung Wook 
Published: June 2023

AbstractBackgroundThe real‐world outcomes of edoxaban treatment in patients with atrial fibrillation (AF) were analyzed in the ETNA‐AF (Edoxaban Treatment in Routine Clinical Practice) study involving data from multiple regional registries. This report addresses effectiveness and safety of edoxaban in the Korean ETNA‐AF population.MethodsOne‐year data from 1887 Korean ETNA‐AF participants were analyzed according to edoxaban dose and patient age and compared with results of other ETNA‐AF registries.ResultsApproximately 70% of patients received the recommended doses of edoxaban (60 mg/30 mg); non‐recommended 60 mg and 30 mg doses were prescribed to 9.6% and 19.8% of the patients, respectively. The proportions of reference age (<65 years), youngest‐old (65–74 years) and middle‐old/oldest‐old (≥75 years) groups were 21.4%, 40.2%, and 38.4%, respectively. Incidence of major or clinically relevant nonmajor bleeding was similar within dose (0.57%–1.71%) and age subgroups (1.26%–1.63%). Incidence of net clinical outcome, a composite of stroke, systemic embolic event, major bleeding, and all‐cause mortality, was also comparable among dose subgroups (1.14%–3.10%) and age subgroups (2.28%–2.78%). The percentage of Korean patients receiving non‐recommended 30 mg (19.8%) was over twice that of the European population (8.4%). However, the clinical outcomes were generally similar among different populations included in the ETNA‐AF study.ConclusionsThe outcomes in the Korean ETNA‐AF population are like those in the global ETNA‐AF population, with overall low event rates of stroke, major bleeding and all‐cause mortality across age and dose subgroups. Edoxaban can be used effectively and safely in specific populations of Korean AF patients, including the elderly.
Edible, strong, and low‐hygroscopic bacterial cellulose derived from biosynthesis and physical modification for food packaging
Authors: Cheung Ka Man , Jiang Zhuolun , Ngai To 
Published: June 2023

AbstractBackgroundThe pervasive presence of plastic packaging has led to significant environmental contamination due to excessive reliance on petrochemicals and the inherent non‐biodegradability of these materials. Bacterial cellulose (BC) films present a viable alternative for food packaging applications, owing to their environmentally friendly synthesis process, non‐toxic nature, robust mechanical strength, and biodegradability. However, the high hygroscopicity of such bio‐based materials has limited their widespread adoption, as it results in diminished strength and barrier properties. In this study, a novel approach for creating edible, transparent, robust, and high‐barrier BC‐based composite packaging was proposed through biosynthesis with the incorporation of soy protein isolate and the physical interpenetration of calcium alginate‐polyethylene glycol as a composite coating.ResultsThe finding demonstrated that the synthesized bio‐based composite material exhibits stability in water, high optical transparency, complete oil resistance, and full degradability within 1 to 2 months. Furthermore, the composite material displayed enhanced mechanical properties in both dry and wet conditions, with a tensile strength of approximately 84 MPa, outperforming commercially available kraft paper and low‐density polyethylene.ConclusionsSoy protein isolate established a rigid, coherent, and homogeneous network with BC fibrils, thereby augmenting mechanical properties. Calcium alginate can be effectively combined with BC, utilizing polyethylene glycol as a binder and plasticizer, to generate a densely packed structure with reduced hygroscopicity. This bio‐based composite material demonstrated considerable potential for application in food packaging and other value‐added sectors as a substitute for non‐degradable plastics. © 2023 Society of Chemical Industry.
Bioinspired Platelet‐Anchored Electrospun Meshes for Tight Inflammation Manipulation and Chronic Diabetic Wound Healing
Authors: Zhang Tianci , Xiang Zehong , Liu Lei , Ma Zhifang , Panteleev Mikhail , Ataullakhanov Fazly I. , Shi Qiang 
Published: June 2023

AbstractTight manipulation of the initial leukocytes infiltration and macrophages plasticity toward the M2 phenotype remain a challenge for diabetic wound healing. Inspired by the platelet function and platelet–macrophage interaction, a platelet‐anchored polylactic acid‐b‐polyethylene glycol‐b‐polylactic acid (PLA‐PEG‐PLA) electrospun dressing is developed for inflammatory modulation and diabetic wounds healing acceleration. PLA‐PEG‐PLA electrospun meshes encapsulated with thymosin β4 (Tβ4) and CaCl2 is fabricated with electrospinning, followed by immersion of electrospun mesh in platelet‐rich plasma to firmly anchor the platelets. It is demonstrated that the anchored platelets on electrospun mesh can enhance the initial macrophage recruitment and control the Tβ4 release from electrospun meshes to facilitate the macrophages polarization to the M2 phenotype. The inflammatory regulation promotes the expression of vascular endothelial growth factor and the migration of vascular endothelial cells for angiogenesis, resulting in accelerated diabetic wounds healing. Therefore, this work paved a new way to design platelet‐inspired electrospun meshes for inflammation manipulation and diabetic wound healing.
Iminopyridine Copper Complex‐Based Catalysts for 1,3‐Dienes Stereospecific Polymerization
Authors: Ricci Giovanni , Leone Giuseppe , Zanchin Giorgia , Masi Francesco , Zacchini Stefano , Bresciani Giulio , Guelfi Massimo , Pampaloni Guido 
Published: June 2023

AbstractSome novel copper complexes are synthesized by reacting copper(II) dichloride and copper(II) dibromide with a series of pyridyl‐imine ligands differing in the nature of the substituents at the iminic carbon and at the imino nitrogen atom. All the complexes are characterized by analytical and infrared data: for some of them single crystals are obtained, and their molecular structure is determined by X‐ray diffraction. The complexes are combined with methylaluminoxane (MAO) for the polymerization of 1,3‐dienes (i.e., 1,3‐butadiene and isoprene) obtaining active and selective catalysts and, in case of isoprene, polymers with quite unusual structures, i.e., predominantly alternating cis‐1,4‐alt‐3,4 structures containing cis‐1,4 units sequences within the polymer chain.
A wideband CMOS LNA using noise‐canceling topology and gm‐boosting technique
Authors: Zheng Yishan , Feng Wenjie , Chen Jiawen , Zhu Haoshen , Qin Pei , Shi Yongrong , Che Wenquan , Xue Quan 
Published: June 2023

AbstractIn this letter, a wideband low noise amplifier (LNA) using noise‐canceling topology and gm‐boosting technique is proposed. The noise‐canceling topology is used in the common gate (CG) amplifier to achieved better noise figure (NF) and wideband input matching. Meanwhile, the requirement of the input transconductance can be obviously decreased due to the application of gm‐boosting technique, which effectively alleviate the trade‐off between power consumption and voltage gain. The 3‐dB bandwidth of the LNA is from 2.1 to 4.1 GHz, covering widely used 5 G wireless communication frequency bands (n1, n7, n38, n41, n66, and n78 bands). The proposed LNA shows a flat and low measured NF of 3.3–3.6 dB within the operating bandwidth, while the peak power gain is 18.7 dB. The power consumption of this circuit is 16 mW with 1.2 V supply voltage, and the core area of the circuit is 0.066 mm2 with only one inductor for the whole chip.
Amide proton transfer‐weighted MRI features of acute ischemic stroke subtypes
Authors: Song Guodong , Chen Yuhui , Luo Xiaojie , Gong Tao , Yang Huan , Zhou Jinyuan , Li Chunmei , Chen Min 
Published: June 2023

AbstractStroke is a highly heterogeneous disorder with distinct subtypes, and the stroke subtype influences the outcome. Amide proton transfer‐weighted (APTW) MRI has been demonstrated to be promising in stroke patients, but the image characteristics of stroke subtypes have not been sufficiently investigated. The purpose of this study was to investigate the APTW MRI features of different subtypes of acute ischemic stroke (AIS). Ninety‐two AIS patients presenting within 96 h of symptom onset were enrolled and examined with a 3.0‐T MRI system. Patients were grouped into four subtypes: lacunar circulation infarcts (LACI, n = 33); total anterior circulation infarcts (TACI, n = 9); partial anterior circulation infarcts (PACI, n = 28); and posterior circulation infarcts (POCI, n = 22). APTW values in the lesion (APTWlesion) and the contralateral normal‐appearing region (APTWcontral) were measured. The change in APTW values between the acute ischemic lesion and the contralateral normal‐appearing region (APTWles‐con) was calculated. A two‐sample t‐test, one‐way ANOVA, and the Chi‐square method were used. There were significant differences between APTWlesion and APTWcontral in the three categories of nonlacunar strokes (TACI, PACI, and POCI, all p < 0.01), but not for lacunar strokes (LACI, p = 0.080). TACI patients had the lowest APTWlesion and APTWles‐con in all groups (p < 0.05). In the POCI group, patients with supratentorial infarcts showed significant differences between APTWlesion and APTWcontral (p = 0.001), while the differences were not significant for infratentorial infarcts (p = 0.135). Our results suggest that the APT effect was heterogeneous in different stroke subtypes, and that APTW MRI gave an excellent performence in depicting nonlacunar AIS in supratentorial locations.
Tailorable mechanical and energy absorption behaviors of 3D printed continuous hybrid fiber reinforced composites
Authors: Zia Ali Akmal , Tian Xiaoyong , Zhang Manyu , Huang Yiming , Wu Lingling , Ghouri Muhammad Azeem , Zhou Jin , Kang Youwei , Li Dichen 
Published: June 2023

Abstract3D printing of continuous fiber‐reinforced thermoplastic composites (CFRPCs) has expanded potential structural application in recent years. However, it is still challenging to tailor the mechanical and energy absorption properties of 3D‐printed composites to fulfill the requirements for critical application conditions. Herein, hybrid fiber (HF) reinforced composites have been prepared by 3D printing of CFRPCs and investigated on the mechanical and energy absorption behaviors. Continuous virgin carbon fibers (CF), Kevlar fibers (KF) (130 Deniers (D), and 200 Deniers (D)) and E‐glass fibers (GF) were used as reinforcing fibers to produce hybrid and non‐hybrids composites. Hybrid composites with different combination of CF + GF, CF + 130D KF, and CF + 200D KF showed tailorable behaviors, such as flexural modulus (16,691.74, 20,372.38, and 19,017.44 MPa), tensile modulus (15,022.6, 16,269.41, and 15,320.58 MPa). And energy absorption behaviors of CF + 130D KF and CF + 200D KF were tailored in both tensile (18,865.25 and 20,302.07 N‐mm, respectively) and bending (3594.54 and 3570.80 N‐mm, respectively) tests compared to other composites which will be ideal for energy absorption applications. Moreover, CF + GF showed tailored strength which could be used in the need of high stiffness. SEM images were providing strong evidence to resist the fracture and breakage patterns, by tailoring the stiffness and elongation properties of fibers in hybrids specimens. Furthermore, positive hybrid effects of CF + KF hybrids in tensile and bending tests were also showing an ideal match of toughness and flexibility. In future, these cost and weight effective hybrids will have potential to apply in aerospace and automobile.
Theoretical descriptions on novel heteroatoms analogs of Hammick silylenes using density functional theory
Authors: Moradian Majid 
Published: June 2023

AbstractIn this investigation, we have been compared and contrasted the substituent effects on stability using ΔΕs‐t (Et − Es), frequency, ΔΕHOMO‐LUMO (ELUMO − EHOMO), polarity, polarizability, Mülliken charge distribution and reactivity descriptors of the singlet and triplet Hammick silylenes derived from silapyridine‐4‐ylidene (1‐s, 2x‐s, 3x‐s and 1‐t, 2x‐t, 3x‐t; x = NH, PH, AsH, O, S, and Se) as well as the synthesized dialkylsilylenes by West (4‐s), Denk (5‐s), and Kira (6‐s). In all cases, singlet (s) silylenes appear as ground states, exhibiting more stability than their corresponding triplet (t) states. All the above s and t silylenes appear as minima on their energy surfaces showing the positive force constant and the positive harmonic vibration frequency. Regardless of how orchestrated substituent groups in either “W” or “chair” position; the most stability is demonstrated by substitution of NH, and O groups in the fused pyrrole ring, while the least stability is considered by Kira's silylene. In contrast to previous report on the N‐Heterocyclic Hammick carbenes, silylenes, and germylenes (NHCs, NHSis, and NHGes) that size, type, orientation, and the number of fused rings pronounced effect on stability of the corresponding divalent species, here σ‐donor/π‐donor groups (such as PH, AsH, S, and Se) similar to σ‐acceptor/π‐donor groups (such as NH and O) stabilize their corresponding silylenes. Furthermore, the scrutinized singlet silylenes reveal lesser nucleophilicity (N), greater electrophilicity (ω), higher chemical potential (μ), higher global hardness (η), and lower global softness (S) than the analogous triplet silylenes. All singlet and triplet species show the maximum electronic charge (ΔNmax) with positive sign.
Preimplantation genetic testing for aneuploidy and chromosomal structural rearrangement: A summary of a nationwide study by the Japan Society of Obstetrics and Gynecology
Authors: Iwasa Takeshi , Kuwahara Akira , Takeshita Toshiyuki , Taniguchi Yuka , Mikami Mikio , Irahara Minoru 
Published: June 2023

AbstractPurposeThe Japan Society of Obstetrics and Gynecology conducted a nationwide clinical study to evaluate the pregnancy outcomes of preimplantation genetic testing for aneuploidy or chromosomal structural rearrangement (PGT‐A/SR).MethodsPatients that had experienced recurrent implantation failure, recurrent pregnancy loss, or chromosomal structural rearrangement were recruited from 200 fertility centers in Japan. For patients in whom one or more blastocysts were classified as euploid or euploid with suspected mosaicism, a frozen–thawed single embryo transfer (ET) was performed.ResultsA total of 10 602 cycles, maternal age 28–50 years, were enrolled in this study. 42 529 blastocysts were biopsied, and 25.5%, 11.7%, and 61.7% of embryos exhibited euploidy, mosaicism, and aneuploidy, respectively. At least one euploid blastocyst was obtained in 38.3% of egg retrieval cycles with embryo biopsy. A total of 6080 ETs were carried out, and the clinical pregnancy rate per ET, ongoing pregnancy rate per ET, and miscarriage rate per pregnancy were 68.8%, 56.3%, and 10.4%, respectively. The rates of clinical pregnancy and miscarriage remained relatively constant across all maternal ages.ConclusionsPreimplantation genetic testing for aneuploidy or chromosomal structural rearrangement may improve the pregnancy rate per ET and reduce the miscarriage rate per pregnancy, especially in patients of advanced maternal age.
Position and Orientation dependent Hybridization and Energy transfer of Dipole Emitter around Plasmonic Homodimers
Authors: Dahiya Annu , Krishnan Raishma , Senthil Kumar Pandian 
Published: June 2023

AbstractA dipole emitter (analogous to organic molecules) placed near any dielectric or metal nanoparticles, based on their spatially constrained location and orientation, vividly emulate optical nanoantennas. Herein, we have extensively simulated the single dipole emitter interaction with spherical homodimers of noble metal gold and silver nanoparticles for different positional dependent orientations, exemplifying systematically the hybridization (Rabi splitting), quenching and diffuse non‐radiative energy transfer effects. The blue‐shifted scattering spectra of the coupled dipole emitter with individual Ag and Au homodimers quantify and corroborate the corresponding quantum yield/efficiency estimations. Such spatially oriented emitter interaction further distinctly reveals the enhanced near‐field and far‐field effects of the plasmonic dimer system in terms of dipolar and quadrupolar resonances, arising due to the induced polarization by respective incident electric and opto‐magnetic field components. Understanding the surface‐enhanced behavior of organic molecules that are either incorporated or randomly attached (experimentally) on the surface of metal nanoparticles will benefit greatly from the present comprehensive data analysis.