bluuebunny/crossref_metadata_2025_split huggingface dataset:
SYNTHESIS OF SILVER NANOPARTICLES AND ANTIMICROBIAL ACTIVITIES OF METHANOLIC EXTRACT OF AZADIRACHTA INDICA LEAF AGAINST ESCHERICHIA COLI, STAPHYLOCOCCUS AUREUS AND CANDIDA ALBICANS
Authors: Agbaje AbdulGaniy , Muhammed Maryam Moyosore , Bello Sharafa Adegoke , Jimoh-Hamza Oluwabukola Kudirat , Kazeem Muinat Olanike , Azeez Zainab Oluwatoyin , Jibril Khadijat Ndagi 
Published: September 2023

Azadirachta indica is a plant commonly known as neem. It is native to the Indian subcontinent and most countries in Africa, including Nigeria. The aim of this study was to synthesise silver nanoparticles and examine antimicrobial activities of crude methanolic extract of Azadirachta indica leaves on clinical isolates of Staphylococcus aureus, Escherichia coli and Candida albicans. Methanol was the solvent used for the extraction. The characterization of synthesized AgNPs was carried out using the UV-Visible spectrophotometer. Antimicrobial activity was conducted using disc diffusion method while the Minimum Inhibitory Concentration (MIC), Minimum Bactericidal Concentration (MBC) and Minimum Fungicidal Concentration (MFC) were determined using broth dilution method. The antimicrobial activity of the synthesized Azadirachta indica AgNPs was carried out using standard agar well diffusion method. Qualitative phytochemicals analysis revealed presence of tannins, phenols, alkaloids, phytosteroid, and terpenoid while flavonoids, steroids and saponin were absent. Antibacterial activities of the extracts using the ditch method (concentrations of 100mg/mL, 50mg/mL, 25mg/mL, 12.5mg/mL, and 6.25mg/mL) recorded no zone of inhibition for Staphylococcus aureus and Escherichia coli. Antimicrobial activity of synthesized silver nanoparticles (AgNPs) from methanolic extract showed no zone of inhibition for Staphylococcus aureus. The zone of inhibition against Escherichia coli was 5.33mm while for Candida albicans the zone of inhibition was 15.33mm. Based on the results obtained from this study, it could be said that methanolic extract of Azadirachta indica leaves contains phytochemicals of pharmacological significance which could be exploited as antifungal agent.
ATMOSPHERE HEMISPHERIC ANALYSIS OF PARTICLES POLLUTION OVER AFRICA
Authors: Lawal Hammed A. , Muhammed Mukhtar I. , Bulus Ibrahim 
Published: September 2023

Particulate Matters (PM) or particle pollution are mixture of microscopic solid and liquid particles present in air. The presence of PM in air can be monitored through modern devices known as Air Quality Sensors. In this study, we seek to investigate the concentration of PM at different latitude in some regions in Africa using purple air data available at map.purpleair.com downloaded for a period of 365 days in some African countries namely; Nigeria, Ghana, Ethiopia, Tanzania, Morocco and Zambia. Using Pearson correlational analysis, findings have revealed that the correlation coefficient r between the average PM concentration in some countries within the Northern hemisphere shows -0.91 and 1 for countries lying in the Southern hemisphere. Taken together, these results suggest that there is an association between the PM and latitude. It can therefore be inferred that the higher the country from the northern hemisphere, the lower the concentration of PM and vice versa.
PENGARUH KEPEMIMPINAN TRANSFORMASIONAL DAN MORAL PRAJURIT TERHADAP KESIAPAN OPERASIONAL SATUAN BATALYON INFANTERI 403/WP
Authors: Utomo Arif Setyo 
Published: September 2023

Batalyon Infanteri 403/WP merupakan satu-satunya satuan tempur yang berlokasi di Kabupaten Sleman DIY. Dalam pelaksanaan tugas pokoknya, satuan ini mengalami berbagai hambatan yang perlu segera diatasi guna terciptanya kesiapan operasional satuan tersebut. Diantaranya yaitu kepemimpinan dan moral prajurit. Tujuan penelitian ilmiah ini adalah untuk mengetahui pengaruh signifikan gaya kepemimpinan transformasional dan moral prajurit terhadap kesiapan operasional satuan di Batalyon Infanteri 403/WP. Jenis penelitian yang digunakan pada penelitian ini adalah Stratified Random Sampling dengan menggunakan pendekatan kuantitatif. Sampel yang diambil sebanyak 229 orang personel Batalyon Infanteri 403/WP. Sumber data diperoleh dari data primer dengan menyebar kuesioner dan data sekunder dengan dokumentasi. Analisis data yang digunakan pada penelitian ini adalah analisis deskripstif dan statistik inferensial dengan menggunakan analisis jalur (Path Analysis) dengan bantuan software SPSS (Statistical Product and Service Solution) versi 25 for windows. Hasil penelitian menunjukkan bahwa Gaya Kepemimpinan Transformasional dan moral prajurit berpengaruh signifikan terhadap kesiapan operasional satuan. Berdasarkan pada kuesioner yang disebarkan kepada responden diperoleh hasil penghitungan Koefisien Determinasi adalah 45%, sehingga dapat disimpulkan bahwa Kesiapan Operasional dipengaruhi oleh Kepemimpinan Transformasional dan Moral Prajurit sebesar 45,0% sedangkan sisanya dipengaruhi oleh faktor lain yang tidak diteliti dalam penelitian ini. Faktor-faktor tersebut antara lain kedisiplinan, semangat, loyalitas dan lain-lain. Pola kepemimpinan transformasional penting untuk diterapkan di satuan Yonif 403/WP karena dianggap dapat memotivasi moral prajurit ke arah yang lebih jelas dan berwujud nyata dikarenakan pemimpin transformasional memiliki karakter yang kharismatik dan mampu membangun ikatan emosional yang kuat untuk mencapai kesiapan operasional satuan
KAPABILITAS KOMPI NUBIKA PUSZIAD DALAM MENGHADAPI ANCAMAN MILITER DAN NONMILITER
Authors: IBROHIM DEVI - 
Published: September 2023

Abstract – Perubahan sangat urgen dalam perkembangan Ilmu Pengetahuan dan Teknologi berimplikasi pada proyeksi ancaman terhadap keutuhan dan keselamatan NKRI, berdasarkan sifatnya adalah ancaman militer dan nonmiliter, yang salah satunya berkaitan dengan ancaman Nubika (Nuklir, Biologi, dan Kimia). Satuan Kompi Nubika Pusziad memiliki tugas pokok dan fungsi melaksanakan dekontaminasi Nubika. Namun demikian, Kapabilitas Kompi Nubika Pusziad belum optimal. Kondisi tersebut, dipengaruhi berbagai faktor/variabel diantaranya Kapabilitas Kompi Nubika Pusziad dan Strategi Kompi Nubika Pusziad menghadapi ancaman Nubika. permasalahan yang diteliti yaitu tentang Kapabilitas Kompi Nubika Pusziad dan Strategi Kompi Nubika Pusziad menghadapi ancaman Militer dan Nonmiliter. Tujuan penelitian untuk menganalisis Kapabilitas Kompi Nubika Pusziad dan Strategi Kompi Nubika Pusziad menghadapi ancaman Militer dan Nonmiliter. Penelitian dilakukan mempergunakan metode kualitatif. Hasil penelitian disini memperlihatkan bahwa: (1) Kapabilitas Kompi Nubika Puziad, aspek Personel saat ini secara kuantitas dan kualitas masih 74% (Mantap II), Alsus dan Matsus Nubika, secara kuantitas mencapai 63,13 % TOP, secara kualitas belum memadai, aspek pendidikan dan latihan masih sangat minim. (2) Strategi Kompi Nubika, aspek kapabilitas organisasi mampu 1 s.d. 3 titik bersamaan (skala kecil), aspek deteksi dan identifikasi ancaman Nubika, masih sangat kurang, serta aspek kerjasama Kompi Nubika dengan instansi terkait (Kenubikaan) perlu ditingkatkan. Kesimpulan bahwa perlunya meningkatkan kapabilitas Kompi Zeni Nubika Pusziad dalam rangka menghadapi ancaman militer dan nonmiliter, meliputi: organisasi, personel, Alsus dan Matsus, pendidikan dan latihan, serta kerjasama (vertikal dan horizontal). Kata Kunci: Kapabilitas, Kompi, Nubika, Pusziad, Ancaman.
STRATEGI PERTAHANAN DI PERAIRAN PEDALAMAN UNTUK MENGHADAPI DARI ANCAMAN NON MILITER
Authors: Ningsih Tiwi Gustria 
Published: September 2023

Program pemerintah untuk memindahkan Ibu Kota Negara telah berjalan dengan disahkannya Undang-Undang Nomor 3 Tahun 2022 tentang Ibu Kota Negara. Badan Perencanaan Pembangunan Nasional (Bappenas) membacakan hasil terkait pemindahan ibu kota negara dalam rapat terbatas kabinet pada saat pengumuman hasil pemilihan presiden dan wakil presiden (pilpres) Republik Indonesia pada akhir April 2019. Pengumuman ini mendapat reaksi pro dan kontra dari sejumlah pihak terkait rencana pemindahan Ibu Kota Negara. Didalam penelitian ini, menggunakan metode deskriptif kualitatif. Wacana untuk pemindahan Ibu Kota Negara (IKN) dari Jakarta ke Kalimantan Timur tidaklah hanya sebatas permasalahan terkait geografi dan lingkungan, tetapi lebih mempertimbangkan pada aspek keamanan negara. Perpindahan ibukota nantinya tentu memiliki dampak positif maupun negatif, salah satunya berpindahnya “centre of gravity”. Istilah ini digunakan untuk menerangkan sumber kekuatan serta sumber penentu kemenangan pada saat berperang. Sebuah analisis strategi pertahanan menerangkan bahwasanya perpindahan Ibu Kota Negara dapat bernilai baik secara strategis maupun taktis. Tetapi itu bukanlah suatu hal yang diperoleh tanpa sebuah usaha. Perlu adanya penyesuaian pada postur pertahanan, terutama gelar kekuatan yang berada di wilayah Kalimantan ini harus diperkuat. Sehingga untuk melakukan hal ini diperlukan komitmen serta sinergitas semua pemangku kepentingan agar hal ini berjalan sesuai rencana, khususnya dari sisi anggaran
Função cognitiva, comportamento alimentar e neuroimagem em obesos: uma revisão sistemática
Authors: Lopes Jaqueline Peixoto , Melo Emanoele Anastácia da Silva Araujo , Kochem Frederico Barreto , Messias Ana Carolina Nader Vasconcelos , Orsini Marco , Bastos Victor Hugo do Vale , Silva Julio Guilherme , Garcia Cristiane Sousa Nascimento Baez , Camilo Luciana Moisés , Sant Anna Junior Mauricio de 
Published: September 2023

Introdução: A obesidade é considerada uma desordem multifatorial influenciada por fatores hormonais, dietéticos, comportamentais, emocionais, atencionais e controle cognitivo que interferem no equilíbrio ingestão e gasto energético. A influência da obesidade no declínio cognitivo e prejuízos a funções e estruturas cerebrais além de sua associação com processos neurodegenerativos precoces tem sido observada. Objetivo: Esta revisão buscou identificar as áreas corticais mais ativadas em indivíduos obesos, investigar a existência de comprometimento cognitivo e a possível interferência no comportamento alimentar. Além disso, buscou-se identificar os métodos de neuroimagem mais utilizados para avaliação desses processos. Buscou-se estudos publicados 2006 e 2021. Foram pesquisadas as bases de dados indexadas PUBMED, LILACS e SCIELO. Foram selecionados estudos observacionais que comparassem indivíduos obesos (IMC > 30 kg/m²) e não obesos. Foi utilizado o Quality Assessment of Observational Cohort and Cross-Sectional Studies da National Heart, Lung and Blood Institute (NIH) para análise de qualidade metodológica. Resultados: Foram reportados 22.484 títulos. Após a aplicação dos critérios de elegibilidade, foram selecionados 154 artigos. Desses, onze foramincluídos para análise nesta revisão. Nesta análise, diferenças foram encontradas quanto ao tempo de reação, acurácia ou áreas cerebrais inativadas durante os testescognitvosou estímulos com figuras de comida entre os grupos estudados. Conclusão: Mudanças estruturais compatíveis com prejuízos na performance cognitiva a longo prazo foram identificadas, assim como alterações estruturais e funcionais que podem auxiliar o entendimento de comportamento alimentar compulsivo presente em indivíduos obesos.
ANALISIS DAMPAK PERMASALAHAN PANDEMI COVID-19 PADA UMKM LISA COLLECTION
Authors: Anggarini Defia Riski 
Published: September 2023

Pengabdian ini bertujuan untuk membantu pelaku UMKM dalam menumbuhkan semangat bangkit dari keterpurukan dampak pandemi Covid-19 melalui berbagai upaya manajemen pemasaran yang baik. Pengabdian ini dilakukan pada mitra UMKM Lisa Collection yang beralokasi di Mall Boemi Kedaton Jl. Sultan Agung No.1, Kedaton, Bandar Lampung. Metode yang digunakan adalah metode survey ke lokasi usaha dan penyampaian solusi dari permasalahan yang terjadi terkait dengan penurunan penjualan dimasa pandemi, berhentinya permintaan dari pelanggan, sulit mengakses pasar, dan belum memaksimalkan pemasaran online serta simulasi dan diskusi mengenai manajemen, pengelolaan keuangan, pemasaran produk dan penerapan program promosi yang berdampak pada kesejahraan UMKM. Solusi permasalahan yang ditawarkan terkait dengan penurunan penjualan adalah melakukan penjualan melalui media sosial, peningkatan pelayanan, dan kualitas produk juga dapat dilakukan terkait masalah berhentinya permintaan dari pelanggan. Kata kunci: Covid-19, Media Sosial, Peningkatan Pelayanan, Kualitas Produk
OPTIMALISASI PENCATATAN AKUNTANSI GUNA MENINGKATKAN EFESIENSI DAN KEEFEKTIFAN KERJA PADA UD. ASTRI BUAH
Authors: Khoiriyah Yaumil 
Published: September 2023

Teknologi di Indonesia saat ini sangat pesat dengan ditandainya usaha-usaha dagang yang didirikan. Setiap perusahaan umumnya memiliki sistem pencatatan yag membantu pelaksanaan kegiatan operasional. Pencatatan transaksi dengan bantuan komputer adalah hal yang sudah biasa, baik dilingkungan perusahaan kecil maupun besar. Kondisi tersebut terjadi karena beberapa keunggulan dalam pengelolaan data transaksi dibandingkan dengan pengolahan data transaksi secara manual. Hasil kegiatan yang dilakukan menunjukan bahwa resiko yang terjadi karena pencatatan yang masih dilakukan secara manual mengakibatkan kurang efektif dan efesiennya dalam melakukan pekerjaan sehingga menimbulkan resiko kurang tertatanya pencatatan dalam kegiatan perusahaan. Dalam hal ini perusahaan dapat melakukan salah satu cara pengoptimalan pencatatan kedalam sistematis atau komputerisasi agar lebih efektif dan efesiennya dalam melakukan kegiatan perusahaan dan memudahkan pekerjaan.Kata kunci : Optimalisasi, Pencatatan, Ms. Excel
THE INFLUENTIAL IMPACTS OF DIGITAL STORYTELLING TOWARDS THE IMPROVEMENT OF EFL LEARNERS’ SPEAKING SKILLS
Authors: Wijaya Kristian Florensio 
Published: September 2023

AbstractIn this ever-changing modern age, EFL educators are still in search of more meaningful speaking learning enterprises by which second language learners are strongly encouraged to endure various L2 communication practice hurdles to transform into more proficient speakers. One of the promising ways to actualize this speaking-learning aspiration is through the use of digital storytelling. Previous researchers believed that digital storytelling could potentially promote a higher degree of speaking learning enjoyment where EFL learners’ speaking competencies can thrive to the utmost potential. This present small-scale library study was initiated to exhaustively investigate the positive influences of digital storytelling on EFL learners’ speaking skills improvement. To release this main study objective, the researcher conducted a thematic analysis of 25 previous digital storytelling and speaking studies to generate more relevant and comprehensible research results. Based on the thematic analysis, the constant utilization of digital storytelling was proved to transform EFL learners into more insightful L2 speakers and promote a psychologically sound speaking learning atmosphere in which their targeted L2 communicative competencies can be fostered to the fullest development. Future researchers need to include broader English language learning scopes and a greater number of reviewed digital storytelling investigations to generate more rewarding research results relevant to the applicability and feasibility of online learning platforms in modern EFL learning enterprises. Keywords: digital storytelling, speaking skills, library study
EXPANSION TREND: INDONESIA'S PALM OIL SECTOR GOVERNMENT PLANTATION HEADING FOR EXTINCTION
Authors: Ovi Vensus Hamubaon Samosir  
Published: September 2023

Palm Oil plantations in Indonesia are experiencing a trend of land expansion. The land expansion makes Indonesia, the country with the largest palm oil plantation land in the world, and at the same time the world's largest producer of palm oil. Land expansion is carried out by Government Plantation, Smallholders Plantation, and Private Plantation. However, when observed in more detail, land expansion from Government Plantation has not shown a significant increase and has recently decreased. Seeing the decline in the land area of Government Plantation amid the trend of land expansion of palm oil plantations in Indonesia, this paper argues that liberalization encourages the government to reduce its economic activity in the palm oil plantation sector, and provides opportunities for the market to develop Smallholders Plantation and Private Plantation. Liberalization encouraged the expansion of plantation land nationally, but limited the increase in the land area of Government Plantation.
Keyword: Oil palm plantation, Expansion, Government Plantation, Smallholders Plantation, Private Plantation, Liberalization
A Study on the Distribution of Shear Forces Between Resisting Mechanisms in an RC Element Without Stirrups
Authors: Pérez Caldentey Alejandro 
Published: September 2023

This paper explores how the shear force distributes itself among the three main shear resistance mechanisms: shear resistance of the uncracked compressed chord, aggregate interlock, and dowel effect. Today’s dominating shear models, the critical crack theory (Muttoni et al. [1]) and the compression field theory (Collins et al. [2]) maintain that the main shear-resisting mechanism is aggregate interlock, while more recent studies (Marí et al. [3]), maintain that the main resistance mechanism is the shear resistance on the uncracked compression chord.
In this paper FEM modelling is used to study a test carried out at the Universidad Politécnica de Madrid (UPM) to try to assign the shear force to the different shear mechanisms for different loading steps and elucidate what finally causes the failure of the structure. The results show that as load is increased the relative part of the shear force taken by the uncracked compressed chord increases until finally shear failure is reached when the principal tensile stress in the area located close to the load but towards the support reaches the tensile resistance of concrete, generating a crack that precipitates the failure of the beam.
Investigating the role of mitochondrial DNA D-loop variants, haplotypes, and copy number in polycystic ovary syndrome: implications for clinical phenotypes in the Chinese population
Authors: Chen Yang , Wu Wei-jia , Xing Li-wei , Zhang Xiao-juan , Wang Jing , Xia Xiao-yan , Zhao Rui , Zhao Rong 
Published: September 2023

BackgroundThe presence of genetic variations in mitochondrial DNA (mtDNA) has been associated with a diverse array of diseases. The objective of this study was to examine the correlations between mtDNA D-loop, its haplotypes, and polycystic ovary syndrome (PCOS) in the Chinese population, and the associations between mtDNA D-loop and symptoms of PCOS. The study also sought to determine whether the mtDNA copy number in Chinese patients with PCOS differed from that of individuals in the control group.MethodsInfertile individuals who only had tubal or male factor treatment were the focus of research by The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO). mtDNA haplotypes were categorized using polymorphic D-loop sites. mtDNA D-loop, PCOS features, and mtDNA haplotypes were analyzed using R software to determine the strength of the association between the three. There are certain DNA haplotypes linked to PCOS. Microdroplet digital polymerase chain reaction (PCR) was used to determine the mtDNA copy number in a convenience sample of 168 PCOS patients and 83 controls.ResultsAmong the research group, the majority of D-loop mutations were infrequent (frequency&lt; 1%), with only 45 variants displaying a minimum allele frequency (MAF) of 5% or higher. No association was found between polymorphism loci in PCOS patients and body mass index (BMI). Noteworthy, C194T, 1A200G, 523delAC, and C16234T showed positive correlations with elevated LH/FSH levels. Additionally, specific polymorphic loci G207A, 16036GGins, and 16049Gins within the D-loop region of mtDNA potentially exerted a protective role in PCOS development. Conversely, no statistical significance was observed in the expression levels of C16291T and T489C. Chinese women with mtDNA haplotype A15 exhibited a decreased risk of developing PCOS. Moreover, a significant difference in mtDNA copy number was detected, with controls averaging 25.87 (21.84, 34.81), while PCOS patients had a mean of 129.91 (99.38, 168.63).ConclusionCertain mtDNA D-loop mutations and haplotypes appear to confer protection against PCOS in Chinese women. In addition, elevated mtDNA copy number may serve as an indicator during early stages of PCOS.
Circulating metabolic signatures of rapid and slow progression to type 1 diabetes in islet autoantibody-positive children
Authors: Lamichhane Santosh , Sen Partho , Dickens Alex M. , Kråkström Matilda , Ilonen Jorma , Lempainen Johanna , Hyöty Heikki , Lahesmaa Riitta , Veijola Riitta , Toppari Jorma , Hyötyläinen Tuulia , Knip Mikael , Orešič Matej 
Published: September 2023

Aims/hypothesisAppearance of multiple islet cell autoantibodies in early life is indicative of future progression to overt type 1 diabetes, however, at varying rates. Here, we aimed to study whether distinct metabolic patterns could be identified in rapid progressors (RP, disease manifestation within 18 months after the initial seroconversion to autoantibody positivity) vs. slow progressors (SP, disease manifestation at 60 months or later from the appearance of the first autoantibody).MethodsLongitudinal samples were collected from RP (n=25) and SP (n=41) groups at the ages of 3, 6, 12, 18, 24, or ≥ 36 months. We performed a comprehensive metabolomics study, analyzing both polar metabolites and lipids. The sample series included a total of 239 samples for lipidomics and 213 for polar metabolites.ResultsWe observed that metabolites mediated by gut microbiome, such as those involved in tryptophan metabolism, were the main discriminators between RP and SP. The study identified specific circulating molecules and pathways, including amino acid (threonine), sugar derivatives (hexose), and quinic acid that may define rapid vs. slow progression to type 1 diabetes. However, the circulating lipidome did not appear to play a major role in differentiating between RP and SP.Conclusion/interpretationOur study suggests that a distinct metabolic profile is linked with the type 1 diabetes progression. The identification of specific metabolites and pathways that differentiate RP from SP may have implications for early intervention strategies to delay the development of type 1 diabetes.
The value of total tumor diameter in unilateral multifocal papillary thyroid carcinoma: a propensity score matching analysis
Authors: Wu Zhu-juan , Xia Bao-ying , Chen Zi-wei , Gong Hao , Abuduwaili Munire , Xing Zhi-chao , Su An-ping 
Published: September 2023

BackgroundTumor multifocality is frequently observed in papillary thyroid carcinoma (PTC). However, the maximum tumor diameter (MTD), currently utilized in various staging schemes, might not accurately indicate the level of aggressiveness exhibited by multifocal tumors. We aimed to investigate the relationship between total tumor diameter (TTD) and clinicopathological features of papillary thyroid carcinoma.MethodsRetrospective data analysis was done on 1936 individuals who underwent complete thyroidectomy for PTC. Patients were classified into subgroups according to unilateral multifocality, central lymph node metastasis (CLNM) and lateral lymph node metastasis (LLNM). The relationships of clinicopathological features among these groups were analyzed.ResultsUnilateral multifocality was observed in 117 patients. The clinicopathological features of the unilateral multifocal PTC were similar to the unifocal PTC with approximate TTD. The unilateral multifocality played no independent role in CLNM and LLNM. Moreover, the efficiency of TTD in predicting CLNM and LLNM was significantly higher than that of MTD.ConclusionIn the case of unilateral multifocal PTC, TTD is a more accurate indicator of the biological characteristics of the tumor than MTD.