bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of Microplastics and Microcystin-LR effect for Asian clams (Corbicula flumine) by a metabolomics approach
Authors: Zhang Jiahua , Wang Jie , Wang Xiaodong , Liu Shikun , Zhou Liang , Liu Xingguo 
Published: April 2023

Abstract
Microplastics (MP) and Microcystins (MCs) are two co-occurring pollutants in freshwater ecosystems that pose significant risks to aquatic organisms and human health. This study investigates the interactions between MP and MCs and their effects on the metabolic responses of freshwater aquaculture. Asian clams have been used as an indicator of Microplastics pollution in freshwater ecosystems. The present study investigates metabolic responses of Asian clams during Microplastics and Microcystin-LR stress to identify health impacts and elucidate mechanistic effects of external stressors on Asian clams. A liquid chromatography/ mass spectrometry (LC–MS)-based metabolomics approach was used to identify metabolic perturbations and histological section technique were used to assess changes of tissues from different Asian clam treat groups. The results showed significantly pathological changes in the gills and hepatopancreas in experimental clam compared to control (healthy) clam. Metabolomics revealed alterations of many metabolites in hepatopancreas of six Asian clam compare groups, reflecting perturbations in several molecular pathways, including energy metabolism, amino acid metabolism, protein degradation/tissue damage and oxidative stress. Overall, this study emphasizes the importance of understanding the interactions between MP and MCs and the need for proactive measures to safeguard freshwater ecosystems and human health.
Compression therapy using surgical gloves was ineffective for the prevention of vincristine-induced neuropathy in patients with malignant lymphoma
Authors: Suyama Takuya , Tsuboi Yuri , Shimizu Misayo , Kuroda Akihiro , Seki Masanori , Shinagawa Atsushi 
Published: April 2023

Abstract
Purpose Vincristine (VCR) often induces peripheral neuropathy (PN) as an adverse event. Currently, there is no consensus about prevention of vincristine-induced PN (VIPN). In this study, we aimed to investigate the efficacy of compression therapy using surgical gloves for preventing VIPN.Methods Patients with malignant lymphoma (vincristine-naïve) who were receiving chemotherapy with cyclophosphamide, doxorubicin, VCR, and prednisolone, with or without rituximab, every 3 weeks for six cycles were eligible. For every VCR infusion, each patient wore two one-size smaller gloves on one hand (study hand) for 90 min. The other hand was bare (control hand). PN was assessed at each treatment using common terminology criteria for adverse events ver. 4.0.Results Fifty-one patients with malignant lymphoma were enrolled and 44 were evaluated. The occurrence rates of grade ≥ 2 sensory PN were 13.6 and 13.6% in the study and control hands, respectively (p = 1.0) at 1 month after treatment. The occurrence rates of grade ≥ 2 motor PN were 15.9 and 15.9% in the study and control hands, respectively (p = 1.0).Conclusion Compression therapy using surgical gloves showed no significant effect for the prevention of VIPN.Trial registration First November 2018 National University Hospital Council of Japan (UMIN 000034145).
Decreased Western Tibet Snow Cover Amplifies the Increase in Summer Concurrent Compound Heatwaves in the Northern Hemisphere
Authors: Jia Xiaojing , Dong Wei 
Published: April 2023

Abstract
The occurrence of summer concurrent compound heatwaves (CCHWs) across multiple regions in the Northern Hemisphere (NH) has substantially increased in recent decades, though the contributions made by external forcings remain uncertain. This work has revealed that decreased summer snow cover over the western Tibetan Plateau (SC_WTP) could have significantly amplified the increase in summer CCHWs in the NH during 1979–2021. These findings are supported by both observational data and Coupled Model Intercomparison Project Phase 6 model simulations. The decreased SC_WTP causes diabatic warming by modulating the surface energy budget and stimulates a tripolar Rossby wave source over the TP. The atmospheric response to the SC_WTP forcing-related disturbance generates a circumglobal circulation pattern, which is accompanied by a weakening of the meridional temperature and a “double jet stream” in the NH. These changes modulate the phase, amplitude, and proportion of quasis-tationary waves 6–8, which results in an increase in CCHWs in the NH.
Association of Communication Competence and Nursing Professionalism with Burnout Among Nurses Working at Coronavirus Residential Treatment Centers
Authors: MOON Hyunjung , LEE Ogcheol , Kim Sunghee 
Published: April 2023

Abstract

Background: Owing to the increasing number of cases of the coronavirus disease, treatment facilities and nursing services were diversifying, necessitating appropriate hiring and operating guidelines. The purpose of this study was to identify the association of communication skills and nursing professionalism with burnout among nurses who have worked at coronavirus residential treatment centers since March 2020.
Methods: This study followed a cross-sectional design. An online survey was conducted in November 2021 using a self-report questionnaire covering sociodemographic characteristics, communication competence, nursing professionalism, and burnout.
Results: The data of 145 nurses were analyzed. The average scores for communication competence, nursing professionalism, and burnout were 3.70, 3.25, and 2.98, respectively. Nursing professionalism was positively correlated with communication competence and negatively correlated with burnout. Factors associated with burnout were the length of residential treatment center service, prior experience in responding to infectious diseases, and nursing professionalism, with an explanatory power of 24.0%.
Conclusions: Higher nursing professionalism, greater experience in responding to infectious diseases, and longer residential treatment center service period were associated with lower burnout. This study provides evidence to frame guidelines for hiring priorities and working conditions in an unfamiliar clinical nursing setting in the context of future infectious disease outbreaks to reduce nurses’ burnout.
Effects of Nickel layer on interfacial micro-structure distribution and macro-mechanical properties for vacuum brazed dissimilar steel joints
Authors: Wang Leilei , Li Nian , Wei Xinlong , Ling Xiang , Li Qingsheng 
Published: April 2023

Abstract
In this paper, nickel-plated Q235 carbon steel and 304 stainless steel were vacuum brazed together using pure copper foil as the filler metal. The effects of nickel plating at the carbon steel surface on the shear strength of the brazed joints were investigated and verified by the finite element analysis method. The microstructure and shear strength of the brazed dissimilar steel joints were characterized by SEM and tensile experiments. The results found that the pure copper brazing material exhibited excellent wettability to the base metal. With the increase of heat treatment temperature and holding time, the plated Ni particles fuse with each other and the boundary of the Ni particles gradually disappears, which increases the diffusion distance of Fe, Ni, and P elements and the width of the interface transition zone. The maximum shear strength of the brazed dissimilar steel joint without the nickel layer is 265.9 MPa for the optimized brazing parameters with 0.06 mm thickness of pure copper foil. After nickel plating on the carbon steel surface with heat treatment of 500 ℃ for 1 h, the shear strength of the brazed dissimilar steel joint reduces to 213.4 MPa, which may be due to the formation of brittle intermetallic compounds by Ni and P elements on the surface of the layer at high temperatures.
A glycomic workflow for LC-MS/MS analysis of urine glycosaminoglycan biomarkers in mucopolysaccharidoses
Authors: Nilsson Jonas , Persson Andrea , Voronstov Egor , Nikpour Mahnaz , Noborn Fredrik , Larson Göran , Blomqvist Maria 
Published: April 2023

Abstract
In recent years, several rational designed therapies have been developed for treatment of mucopolysaccharidoses (MPS), a group of inherited metabolic disorders in which glycosaminoglycans (GAGs) are accumulated in various tissues and organs. Thus, improved disease-specific biomarkers for diagnosis and monitoring treatment efficacy are of paramount importance. Specific non-reducing end GAG structures (GAG-NREs) have become promising biomarkers for MPS, as the compositions of the GAG-NREs depend on the nature of the lysosomal enzyme deficiency, thereby creating a specific pattern for each subgroup. However, there is yet no straightforward clinical laboratory platform which can assay all MPS-related GAG-NREs in one single analysis. Here, we developed and applied a GAG domain mapping approach for analyses of urine samples of ten MPS patients with various MPS diagnoses and corresponding aged-matched controls. We describe a nano-LC-MS/MS method of GAG-NRE profiling, utilizing 2-aminobenzamide reductive amination labeling to improve the sensitivity and the chromatographic resolution. Diagnostic urinary GAG-NREs were identified for MPS types IH/IS, II, IIIc, IVa and VI, corroborating GAG-NRE as biomarkers for these known enzyme deficiencies. Furthermore, a significant reduction of diagnostic urinary GAG-NREs in MPS IH (n = 2) and MPS VI (n = 1) patients under treatment was demonstrated. We argue that this straightforward glycomic workflow, designed for the clinical analysis of MPS-related GAG-NREs in one single analysis, will be of value for expanding the use of GAG-NREs as biomarkers for MPS diagnosis and treatment monitoring.
Mixed medullary and follicular cell derived thyroid carcinoma-series of three cases
Authors: Fonseca Daphne , Arya Sahithi Shilpa , Bikkina Pratyusha , P Madhu Vijay , Kodandapani Suseela , Rao Chandrasekhar , A Zakir Ali 
Published: April 2023

Abstract
Papillary thyroid carcinoma and medullary thyroid carcinoma are two distinct types of thyroid carcinoma. Mixed thyroid carcinoma is a rare form of thyroid cancer accounting for less than 0.5% of thyroid malignancies. We present a series of mixed PTC and MTC with details of their clinic-radiological, pathological diagnosis and follow up.
Interplay between Zika virus-induced autophagy and neural stem cell fate determination
Authors: . Bindu , Pandey Hriday Shanker , Seth Pankaj 
Published: April 2023

Abstract
The Zika virus (ZIKV) outbreaks and its co-relation with microcephaly have become a global health concern. It is primarily transmitted by a mosquito, but can also be transmitted from an infected mother to her fetus causing impairment in brain development, leading to microcephaly. However, the underlying molecular mechanism of ZIKV-induced microcephaly is poorly understood. In this study, we explored the role of ZIKV non-structural protein NS4A and NS4B in ZIKV pathogenesis in a well-characterized primary culture of human fetal neural stem cells (fNSCs). We observed that the co-transfection of NS4A and NS4B altered the neural stem cell fate by arresting proliferation and inducing premature neurogenesis. NS4A-NS4B transfection in fNSCs increased autophagy and dysregulated notch signalling. Further, it also altered the regulation of downstream genes controlling cell proliferation. Additionally, we reported that 3 methyl-adenine (3MA), a potent autophagy inhibitor, attenuated the deleterious effects of NS4A and NS4B as evidenced by the rescue in Notch1 expression, enhanced proliferation, and reduced premature neurogenesis. Our attempts to understand the mechanism of autophagy induction indicate the involvement of mitochondrial fission and ROS. Collectively, our findings highlight the novel role of NS4A and NS4B in mediating NSC fate alteration through autophagy-mediated notch degradation. The study also helps to advance our understanding of ZIKV-induced neuropathogenesis and suggests autophagy as a potential target for anti-ZIKV therapeutic intervention.
Effectiveness of non-immersive virtual reality in the management of procedure-related pain in preschool children: A randomized clinical trial
Authors: Camacho-Cruz Jhon , Palacios-Ariza María Alejandra , Orrego-Celestino Luisa , Valbuena-Velandia Natalia , Paez-Castellanos Laura , Bolaños Johanna M. , Pradilla Ivan 
Published: April 2023

Abstract
Objective
To assess the effectiveness of non-immersive virtual reality as a pain-distraction measure in children between the ages of 3–5 years undergoing painful injection procedures in an outpatient setting.
Design
We carried out a randomized, unmasked clinical trial in children undergoing venipuncture or intramuscular injection procedures. Patients were randomized to a distraction virtual reality video or standard care. After the procedure, three independent observers (parents, researchers, nursing staff) rated pain on the LLANTO pain scale.
Results
We recruited 122 subjects, half of which were randomized to virtual reality. The median age was of approximately 5 years and the sample was balanced with regards to sex. Agreement between raters was high for all three types of observers, with Cohen Kappas over 0.79 in all cases. Bivariate analysis showed reductions in the risk of obtaining higher scores in the LLANTO scale. Linear regression models showed a reduction of approximately 3 points in the scale, regardless of the type of observer. These models were adjusted for sex, age, kind of procedure, use of prior analgesia, and recruitment center.
Conclusions
Non-immersive virtual reality is an effective adjunctive therapy for the reduction of pain in children undergoing painful injection procedures in an outpatient setting. This strategy may be used to improve the quality of care in pediatric outpatient services.
Trial Registration:
ClinicalTrials.gov Identifier: NCT03985930
Multiple bone metastases in advanced breast cancer: a gastrointestinal surgical emergency
Authors: Wang# Xixi , Lin Junyi , Li Zhi , Wang Minghua 
Published: April 2023

Abstract
Patient: Female, 33-year-old
Final Diagnosis: Advanced breast cancer with bone metastasis
Symptoms: Acute Abdominal pain
Clinical Procedure: —
Specialty: General Surgery • Oncology
Objective:
Unusual clinical course
Background:
Globally, acute abdominal pain is a common reason for admission to emergency departments. As with fever, it can be difficult to identify the cause. Metastatic breast cancer, which usually spreads to the lungs, brain, liver, and bones, is living longer among patients. Metastasis may present complications that were not previously seen due to improved survival rates. Patients with advanced metastatic breast cancer who experience sudden acute abdominal pain are at risk for this rare complication.
Case Report:
In an emergency department of gastrointestinal surgery, a 33-year-old female presented with sudden acute abdominal pain for no apparent reason. It was highly suspected that the patient had acute appendicitis based on his history and physical examination. CT scans of the chest and abdomen in the emergency department revealed bilateral breast cancer with multiple bone metastases (lumbar spine, iliac crest). Emergency abdominal exploration was performed after the patient's abdominal pain aggravated. In the patient's abdomen, extensive metastasis and cancerous adhesions were discovered, and the prognosis was extremely poor. It was not possible to explore the appendix and intestines further, so abdominal irrigation, abscess drainage, and abdomen closure were performed. Upon recovery from surgery, the patient was transferred to the Department of Breast and Thyroid Surgery for chemotherapy. A first course of doxorubicin liposome + cyclophosphamide chemotherapy was followed by a second course of albumin + paclitaxel chemotherapy. During the first course of treatment, a CT examination revealed new lumbar metastases and a reduction of the right breast mass. We are now in the process of further treatment and follow-up observation.
Conclusions:
A clinician should consider metastatic breast cancer pain when treating a female patient with acute abdominal pain. It is possible to die from acute abdominal pain, which has a wide range of causes. When breast cancer is not detected early, it can also occur repeatedly with various other clinical manifestations in the later stages.
The upregulation of peripheral CD3-CD56+CD16+ natural killer cells correlates with Th1/Th2 imbalance in asthma patients during acute upper respiratory viral infections
Authors: Liu Meixuan , Zhang Yunxuan , Hu Yunqian , Guo Zhongliang , Dong Lin 
Published: April 2023

Abstract
Purpose：The aim of this study is to clarify the changes of peripheral CD3-CD56+CD16+ NK cells and their correlation with Th1/Th2 immunity profiles in asthma during the phase of acute upper respiratory viral infections (AURVIs).
Methods: Peripheral venous blood and induced sputum samples were collected from 56 mild asthma patients, 49 asthma patients with AURVIs and 50 healthy subjects. Peripheral CD3-CD56+CD16+ NK cells were monitored by flow cytometry during the course of acute viral infections. Meanwhile, the induced sputum Th1 cytokines IL-4 and IL-5, and Th2 cytokine INF-γ were also detected by ELISA assay.
Results: The asthmatics had lower levels of peripheral CD3-CD56+CD16+ NK cells populations as well as higher induced sputum cytokines (IL-4, IL-5 and IFN-γ) compared to healthy control at baseline. Upon upper respiratory viral infections, peripheral CD3-CD56+CD16+ NK cells numbers in asthma patients sharply elevated on day 3 and slowly decreased by day 14, in accordance with induced sputum INF-γ changes. IL-4 and IL-5 levels spiked much later (day 8) and lasted until day 14. Compared with asthma alone group, the IFN-γ/IL-4 and IFN-γ/IL-5 ratios of the asthma patients with AURVIs on day 1 were higher and peaked on day 3. The changes of peripheral CD3-CD56+CD16+ NK cells proportions positively correlated with the IFN-γ/IL-4 and IFN-γ/IL-5 ratios on day 1 to day 3 in asthma subsequent to upper respiratory viral infections.
Conclusions: Our findings showed an imbalanced Th1/Th2 immunity in airways of asthma with acute upper respiratory viral infections. Upregulated peripheral CD3-CD56+CD16+ NK cells play a crucial role in biased Th1 immunity of airways in asthma during the acute phase of viral infections. The anti-viral Th1 immunity by targeting NK cells may be a possible therapeutic option for virus-induced asthma exacerbation.
Phytochemical Constituents from the seeds of Capsella bursa-pastoris and their antioxidant activities
Authors: Zhou Ti-Qiang , Wei Zhen-Zhen , Zhang Jin-Rui , Dong Jia-Hui , Liu Chun-Ying , Jiang Cong-Zhi , Xia Zi-Ming , Liu Si-Fan , Li Min , Zhang Guang-jie , Chen Li , Tian Ying , Li Bin , Liu Shu-Chen 
Published: April 2023

Abstract
Phytochemical investigation of 70% EtOH extract of the seeds of Capsella bursa-pastoris led to the isolation of a new cyclobutane organic acid (1), and fourteen known compounds, including two organosulfur compounds (2, 3), two quinonoids (4, 5), five flavonoids (6-10), three steroidals (11-13) and two other types (14, 15). The structures of the compounds were elucidated by extensive spectroscopic analyses as well as comparison of their spectroscopic data with those reported in the literature. The antioxidant capacities of all the compounds and the extractive fractions were evaluated by the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical-scavenging test and ferric reducing antioxidant power (FRAP) assay. Then the antioxidative substances were evaluated for their neuroprotective effects against H2O2-induced HT22 cell injury. The results indicated the extractive fractions and the compounds 1-3, 8-10 and 13 had strong scavenging ability to free radical, and the reduction power of the extractive fractions and compounds 1-3, 8 and 10 were close to or higher than that of the positive control trolox. The EtOAc fraction, n-BuOH fraction, and compounds 1, 3 and 8 can protect HT-22 cells from oxidative damage.
Pharmacokinetics study of oxyclozanide and levamisole hydrochloride compound suspension in sheep by LC-MS/MS
Authors: CHEN Lingling , ZHANG Donghui , GAO Xin’er , YAO Xueqiang , SHI Mengyan , ZHANG Xinxin , ZHOU Xuzheng , ZHANG Jiyu 
Published: April 2023

Abstract
Background: Oxyclozanide and Levamisole hydrochloride compounded suspensions is a kind of compound anthelmintics widely used in the treatment of Fasciola hepatica and nematodes in cattle and sheep. In order to compare the pharmacokinetic parameters between the self-develop drug and the reference listed drug in sheep of the oxyclozanide and levamisole hydrochloride compound suspension, a rapid and sensitive LC-MS/MS analytical method was established, mebendazole was used as the internal standard (IS) in positive ion mode and niclosamide was used as the internal standard (IS) in negative ion mode. The method was validated in terms of linearity, selectivity, specificity, accuracy, precision, and matrix effect, and was successfully applied to a pharmacokinetic study of oxyclozanide and levamisole hydrochloride compounded suspensions in healthy sheep.
·Results: A simple and rapid LC-MS/MS analytical method was established and validated to quantify oxyclozanide and levamisole hydrochloride levels in sheep. The main pharmacokinetic parameters, that is, the maximum plasma concentrations (Cmax), the time to maximum concentration (Tmax), area under the time curve concentration (AUClast) and Terminal half-life (T1/2): the self-developed drug and the reference listed drug of oxyclozanide were 45.54±17.58 μg/mL, 22.5±2.07 h, 1845.43±851.92 h*μg/mL, 20.58±7.97 h; 34.60±5.65 μg/mL, 15.50±3.96 h, 1285.46±225.7 h*μg/mL, 23.12±5.04 h, respectively; The self-developed drug and the reference listed drug of Levamisole hydrochloride was : 2.25±0.90 μg/mL, 0.49±0.69 h, 9.51±2.20 h*μg/mL, 4.43±1.75 h; 2.41±1.11 μg/mL, 0.81±0.66 h, 9.09±2.12 h*μg/mL, 3.16±1.05 h. No significant differences were observed among the AUClast andT1/2 for Oxyclozanide self-developed drug compare with the reference listed drug, and there was a significant difference in Cmax and Tmax (P＜0.05). There were no significant differences in Cmax, Tmax, AUClast and T1/2 between the self-developed drug of levamisole hydrochloride and the reference listed drug (P > 0.05). The relative bioavailability of oxyclozanide and levamisole hydrochloride were 143.56% and 104.62%, respectively.
Conclusions: A reliable, accurate LC-MS/MS analytical method was established in our study and successful applied to study the pharmacokinetics of oxyclozanide and levamisole hydrochloride compound suspension in sheep plasma. These results will be useful for further evaluations of the pharmacokinetic properties of oxyclozanide and levamisole hydrochloride.
A Serendipity Recommendation Method for Book Categories Using BERT
Authors: Kim Youngmo , Kim Seok-Yoon , Park Byeongchan 
Published: April 2023

Abstract
In the field of book search, research on a web service-based user customized book recommendation system is being conducted to respond to increasingly diversified user requirements. The collaborative filtering algorithm, which is mainly used for book recommendation, has a problem in that it is difficult to reflect the user's recent interest without considering the change in preference over time, and the user's satisfaction decreases because it repeatedly recommends only similar items. In this paper, we propose a book recommendation method using category similarity based on deep learning. The proposed method is to predict books to be used next time by inputting users' past and current book usage history through BERT, a natural language processing model, and to recommend popular books in other categories with high similarity to the predicted book category in the BERT model to reflect serendipity. This method reflects serendipity, which can lead to users' recent interests and practical preferences, so that recommendation accuracy and user satisfaction can be satisfied at the same time.