bluuebunny/crossref_metadata_2025_split huggingface dataset:
Construction and validation of a cuproptosis-related diagnostic gene signature for atrial fibrillation based on ensemble learning
Authors: Wang Yixin , Wang Qiaozhu , Liu Peng , Jin Lingyan , Qin Xinghua , Zheng Qiangsun 
Published: August 2023

Abstract
Background
Atrial fibrillation (AF) is the most common type of cardiac arrhythmia. Nonetheless, the accurate diagnosis of this condition continues to pose a challenge when relying on conventional diagnostic techniques. Cell death is a key factor in the pathogenesis of AF. Existing investigations suggest that cuproptosis may also contribute to AF. This investigation aimed to identify a novel diagnostic gene signature associated with cuproptosis for AF using ensemble learning methods and discover the connection between AF and cuproptosis.

Results
Two genes connected to cuproptosis, including solute carrier family 31 member 1 (SLC31A1) and lipoic acid synthetase (LIAS), were selected by integration of random forests and eXtreme Gradient Boosting algorithms. Subsequently, a diagnostic model was constructed that includes the two genes for AF using the Light Gradient Boosting Machine (LightGBM) algorithm with good performance (the area under the curve value > 0.75). The microRNA-transcription factor-messenger RNA network revealed that homeobox A9 (HOXA9) and Tet methylcytosine dioxygenase 1 (TET1) could target SLC31A1 and LIAS in AF. Functional enrichment analysis indicated that cuproptosis might be connected to immunocyte activities. Immunocyte infiltration analysis using the CIBERSORT algorithm suggested a greater level of neutrophils in the AF group. According to the outcomes of Spearman’s rank correlation analysis, there was a negative relation between SLC31A1 and resting dendritic cells and eosinophils. The study found a positive relationship between LIAS and eosinophils along with resting memory CD4+ T cells. Conversely, a negative correlation was detected between LIAS and CD8+ T cells and regulatory T cells.

Conclusions
This study successfully constructed a cuproptosis-related diagnostic model for AF based on the LightGBM algorithm and validated its diagnostic efficacy. Cuproptosis may be regulated by HOXA9 and TET1 in AF. Cuproptosis might interact with infiltrating immunocytes in AF.
Assessment of antigenemia among children in four hotspots of filarial endemic districts of Nepal during post-MDA surveillance
Authors: Mehta Pramod Kumar , Maharjan Mahendra 
Published: August 2023

Abstract
Background
Sixty-three out of 77 districts reported lymphatic filariasis (LF) endemic in Nepal. Mass drug administration (MDA) with diethylcarbamazine (DEC) and albendazole (ALB) treatment program was continued for 6 to 11 rounds in these districts. Nepal government has stopped the MDA program based on the transmission assessment survey (TAS) report of 2014 and 2018 indicating Wuchereria bancrofti antigenemia prevalence < 2%. But the persistence of low levels of the circulating filarial antigen (CFA) in some foci of four endemic districts of Central Nepal, i.e., 0.4% in Dhading, 0.7% in Mahottari, 0.21% in Lalitpur and 1.2% in Bara district could responsible for enhancing the risk of infection resurgence. Hence the present study was designed to assess antigenic prevalence using Filariasis Test Strip (Alere, Scarborough ME) in children born after MDA in hotspot areas of four endemic districts of Central Nepal.

Results
The present study covers 70% children of the eligible population. The result revealed significantly high CFA prevalence in hotspots of Mahottari district belonging to the Terai region and Dhading district belonging to the hilly region, i.e., 13% and 10%, respectively, compared to baseline prevalence and TAS report. While in Lalitpur district and Bara district CFA prevalence was still found to be less than 2%. A higher number of MDA rounds covered in hotspots were found significantly associated with the low antigenic prevalence of W. bancrofti. Whereas median treatment coverage and inter-quartile range (IQR) in study districts were not found significantly associated with CFA prevalence. Although the clinical manifestation of hydrocele (1%) was found in all four study districts, it was not due to the W. bancrofti infection.

Conclusions
Two hotspot regions, one each from the Terai (Mahottari) and hilly (Dhading) districts were found highly prevalent with CFA and significantly associated with the number of MDA rounds but were not associated with treatment coverage and IQR. Higher CFA prevalence was observed in hotspots where baseline prevalence was high together indicating that rounds of MDA program need to be extended further in these hotspot regions of endemic districts.
Binary Extended Formulations and Sequential Convexification
Authors: Aprile Manuel , Conforti Michele , Di Summa Marco 
Published: August 2023

A binarization of a bounded variable x is obtained via a system of linear inequalities that involve x together with additional variables [Formula: see text] in [Formula: see text] so that the integrality of x is implied by the integrality of [Formula: see text]. A binary extended formulation of a mixed-integer linear set is obtained by adding to its original description binarizations of its integer variables. Binary extended formulations are useful in mixed-integer programming as imposing integrality on 0/1 variables rather than on general integer variables has interesting convergence properties and has been studied from both the theoretical and practical points of view. We study the behavior of binary extended formulations with respect to sequential convexification. In particular, given a binary extended formulation and one of its variables x, we study a parameter that measures the progress made toward enforcing the integrality of x via application of sequential convexification. We formulate this parameter, which we call rank, as the solution of a set-covering problem and express it exactly for the classic binarizations from the literature. Funding: M. Aprile and M. Di Summa are supported by the University of Padova [SID 2019 Grant C94I20000280005].
O/a pedagogo/a na universidade: o papel dos serviços de apoio pedagógico na política de assistência estudantil
Authors: Magalhães Jonas Emanuel Pinto 
Published: August 2023

O presente artigo tem como motivação principal problematizar os espaços e as possibilidades de atuação do/a pedagogo/a na universidade e em instituições de ensino superior (IES). De modo mais específico, busca refletir sobre a importância desse profissional na atual política de assistência estudantil, mormente nos serviços e ações de apoio pedagógico que compõem uma das linhas de atuação do Plano Nacional de Assistência Estudantil (PNAES). Apoiando-se em uma pesquisa de tipo bibliográfica e documental, discutimos as mudanças no perfil dos estudantes das IES públicas, sua relação com as políticas de reserva de vagas em curso desde a última década e a indispensável consecução de políticas estudantis de assistência e permanência que garantam não só o acesso, mas a permanência e o sucesso escolar dos estudantes mais vulneráveis no ensino superior. Apresentamos estudos sobre os processos de transição e integração de estudantes no ambiente universitário que apontam para a necessidade premente de criação de dispositivos que contribuam para o atendimento de dificuldades de aprendizagem, desenvolvimento de habilidades de estudo e integração social e acadêmicos dos estudantes no ensino superior. Finalmente, defendemos a relevância dos serviços de apoio pedagógico no referido contexto e a primazia da atuação do/a pedagogo/a em ações dessa natureza, em razão da importância de se qualificar esse serviço conferindo-lhe um olhar especializado, reflexivo e crítico.
Kynurenic acid, a key L-tryptophan-derived metabolite, protects the heart from an ischemic damage
Authors: Bigelman Einat , Pasmanik-Chor Metsada , Dassa Bareket , Itkin Maxim , Malitsky Sergey , Dorot Orly , Pichinuk Edward , Kleinberg Yuval , Keren Gad , Entin-Meer Michal 
Published: August 2023

Background
Renal injury induces major changes in plasma and cardiac metabolites. Using a small- animal in vivo model, we sought to identify a key metabolite whose levels are significantly modified following an acute kidney injury (AKI) and to analyze whether this agent could offer cardiac protection once an ischemic event has occurred.

Methods and results
Metabolomics profiling of cardiac lysates and plasma samples derived from rats that underwent AKI 1 or 7 days earlier by 5/6 nephrectomy versus sham-operated controls was performed. We detected 26 differential metabolites in both heart and plasma samples at the two selected time points, relative to sham. Out of which, kynurenic acid (kynurenate, KYNA) seemed most relevant. Interestingly, KYNA given at 10 mM concentration significantly rescued the viability of H9C2 cardiac myoblast cells grown under anoxic conditions and largely increased their mitochondrial content and activity as determined by flow cytometry and cell staining with MitoTracker dyes. Moreover, KYNA diluted in the drinking water of animals induced with an acute myocardial infarction, highly enhanced their cardiac recovery according to echocardiography and histopathology.

Conclusion
KYNA may represent a key metabolite absorbed by the heart following AKI as part of a compensatory mechanism aiming at preserving the cardiac function. KYNA preserves the in vitro myocyte viability following exposure to anoxia in a mechanism that is mediated, at least in part, by protection of the cardiac mitochondria. A short-term administration of KYNA may be highly beneficial in the treatment of the acute phase of kidney disease in order to attenuate progression to reno-cardiac syndrom and to reduce the ischemic myocardial damage following an ischemic event.
Prehospital prediction of hospital admission for emergent acuity patients transported by paramedics: A population-based cohort study using machine learning
Authors: Strum Ryan P. , Mowbray Fabrice I. , Zargoush Manaf , Jones Aaron P. 
Published: August 2023

Introduction
The closest emergency department (ED) may not always be the optimal hospital for certain stable high acuity patients if further distanced ED’s can provide specialized care or are less overcrowded. Machine learning (ML) predictions may support paramedic decision-making to transport a subgroup of emergent patients to a more suitable, albeit more distanced, ED if hospital admission is unlikely. We examined whether characteristics known to paramedics in the prehospital setting were predictive of hospital admission in emergent acuity patients.

Materials and methods
We conducted a population-level cohort study using four ML algorithms to analyze ED visits of the National Ambulatory Care Reporting System from January 1, 2018 to December 31, 2019 in Ontario, Canada. We included all adult patients (≥18 years) transported to the ED by paramedics with an emergent Canadian Triage Acuity Scale score. We included eight characteristic classes as model predictors that are recorded at ED triage. All ML algorithms were trained and assessed using 10-fold cross-validation to predict hospital admission from the ED. Predictive model performance was determined using the area under curve (AUC) with 95% confidence intervals and probabilistic accuracy using the Brier Scaled score. Variable importance scores were computed to determine the top 10 predictors of hospital admission.

Results
All machine learning algorithms demonstrated acceptable accuracy in predicting hospital admission (AUC 0.77–0.78, Brier Scaled 0.22–0.24). The characteristics most predictive of admission were age between 65 to 105 years, referral source from a residential care facility, presenting with a respiratory complaint, and receiving home care.

Discussion
Hospital admission was accurately predicted based on patient characteristics known prehospital to paramedics prior to arrival. Our results support consideration of policy modification to permit certain emergent acuity patients to be transported to a further distanced ED. Additionally, this study demonstrates the utility of ML in paramedic and prehospital research.
Clinical characteristics and outcomes of patients with chronic systemic inflammatory disease in acute myocardial infarction
Authors: Yaginuma Hiroaki , Saito Yuichi , Sato Takanori , Yamashita Daichi , Matsumoto Tadahiro , Suzuki Sakuramaru , Wakabayashi Shinichi , Kitahara Hideki , Sano Koichi , Kobayashi Yoshio 
Published: August 2023

Background
Chronic systemic inflammatory diseases (CSIDs) such as rheumatoid arthritis (RA) are reportedly associated with an increased risk of ischemic cardiovascular events including acute myocardial infarction (MI). However, data are limited on clinical characteristics and ischemic and bleeding outcomes after acute MI in patients with CSIDs.

Methods
This bi-center registry included a total of 1001 patients with acute MI undergoing percutaneous coronary intervention. CSIDs included inflammatory rheumatological conditions (RA, systemic lupus erythematosus, vasculitis, etc.) and organ-specific diseases (chronic hepatitis, psoriasis, inflammatory bowel disease, etc.). The primary endpoint was net adverse clinical events (NACE), a composite of ischemic (all-cause death, MI, and ischemic stroke) and major bleeding (Bleeding Academic Research Consortium type 3 or 5) events, during hospitalization and after discharge.

Results
Of the 1001 patients, 58 (5.8%) had CSIDs. The proportion of women was higher in patients with CSIDs than those without (37.9% vs. 22.1%, p = 0.009). During the hospitalization, no significant differences in the primary endpoint of NACE were observed between patients with and without CSIDs (10.3% vs. 12.7%, p = 0.84). During the median follow-up of 42.6 months after discharge, patients with CSIDs had a higher risk of NACE (22.5% vs. 10.1%, p = 0.01) than those without, mainly driven by an increased risk of ischemic events (18.4% vs. 8.4%, p = 0.03).

Conclusions
A small but significant proportion of patients with acute MI (5.8%) had CSIDs. While the incidence of in-hospital events was similar, patients with CSIDs had worse outcomes after discharge, suggesting that further clinical investigations and therapeutic approaches are needed in this patient subset.
Potentially inappropriate medication uses and associated factors among elderly primary health care clinics attendees: A call to action
Authors: Samara Esra’a , Nazzal Zaher , Naghnaghia Shayma , AL-Ramahi Rowa’ 
Published: August 2023

Background
Polypharmacy is a significant risk factor for using potentially inappropriate medication (PIM), which is using drugs with more risks than benefits, especially for elders. This study aimed to estimate the prevalence of PIM using Beers Criteria, polypharmacy, and their related risk factors.

Methods
A descriptive cross-sectional study was conducted in West Bank primary health care clinics (PHC)from December 2021 to March 2022. Data were collected from PHC clinic attendees aged 65 and above via an interviewer-administered questionnaire and a review of their medical records. We used the Beers Criteria 2019 update to identify PIM and performed a multivariable analysis to determine its associated factors.

Results
The study included 421 older people (197 men and 224 women) with an average age of 73.6 years. The prevalence of polypharmacy was 75.1% (95%CI: 70.6%-79.1%), with an average of six medications dispensed per patient. On the other hand, PIM was identified among 36.8% of the study participants (CI:95%CI: 32.2%- 41.6%). Sulfonylureas were the most common (24.2%) reported PIM, followed by peripheral alpha-blockers (4.3%), non-steroidal anti-inflammatory drugs (3.1%), proton pump inhibitors (2.9%), and central nervous system medications (2.1%). Hyperpolypharmacy (> 10 drugs) [aOR = 4.1, 95%CI: 1.6–10.7], polypharmacy [aOR = 2.8, 95%CI: 1.4–5.4], and Diabetes [aOR = 3.5, 95%CI: 2.0–6.0] are the main associated factors of PIM.

Conclusion
This study found that over one-third of the older people attending PHC clinics have PIM, with polypharmacy and Diabetes being the main predicting variables. Improving physicians’ awareness of clear and specific PIM lists can reduce the number of PIM prescribed and decrease their impact.
Rigidity of four-dimensional gradient shrinking Ricci solitons
Authors: Cheng Xu , Zhou Detang 
Published: August 2023

Abstract
Let

(
M
,
g
,
f
)

{{(M,g,f)}}

be a four-dimensional complete noncompact gradient shrinking Ricci soliton with the equation

Ric
+

∇
2

⁡
f

=

λ
⁢
g

{{\mathrm{Ric}+\nabla^{2}f=\lambda g}}

, where

λ

{{\lambda}}

is a positive real number. We prove that if

M

{{M}}

has constant scalar curvature

S
=

2
⁢
λ

{{S=2\lambda}}

, it must be a quotient of

𝕊
2

×

ℝ
2

{{\mathbb{S}^{2}\times\mathbb{R}^{2}}}

. Together with the known results, this implies that a four-dimensional complete gradient shrinking Ricci soliton has constant scalar curvature if and only if it is rigid, that is, it is either Einstein, or a finite quotient of Gaussian shrinking soliton

ℝ
4

{{\mathbb{R}^{4}}}

,

𝕊
2

×

ℝ
2

{{\mathbb{S}^{2}\times\mathbb{R}^{2}}}

or

𝕊
3

×
ℝ

{{\mathbb{S}^{3}\times\mathbb{R}}}

.
Crystal limits of compact semisimple quantum groups as higher-rank graph algebras
Authors: Matassa Marco , Yuncken Robert 
Published: August 2023

Abstract
Let

O
q

⁢

[
K
]

\mathcal{O}_{q}[K]

be the quantized coordinate ring over the field

C
⁢

(
q
)

\mathbb{C}(q)

of rational functions corresponding to a compact semisimple Lie group 𝐾, equipped with its ∗-structure.
Let

A
0

⊂

C
⁢

(
q
)

{\mathbf{A}_{0}}\subset\mathbb{C}(q)

denote the subring of regular functions at

q
=
0

q=0

.
We introduce an

A
0

\mathbf{A}_{0}

-subalgebra

O
q

A
0

⁢

[
K
]

⊂

O
q

⁢

[
K
]

\mathcal{O}_{q}^{{\mathbf{A}_{0}}}[K]\subset\mathcal{O}_{q}[K]

which is stable with respect to the ∗-structure and which has the following properties with respect to the crystal limit

q
→
0

q\to 0

.
The specialization of

O
q

⁢

[
K
]

\mathcal{O}_{q}[K]

at each

q
∈

(
0
,
∞
)

∖

{
1
}

q\in(0,\infty)\setminus\{1\}

admits a faithful ∗-representation

π
q

\pi_{q}

on a fixed Hilbert space, a result due to Soibelman.
We show that, for every element

a
∈

O
q

A
0

⁢

[
K
]

a\in\mathcal{O}_{q}^{{\mathbf{A}_{0}}}[K]

, the family of operators

π
q

⁢

(
a
)

\pi_{q}(a)

admits a norm limit as

q
→
0

q\to 0

.
These limits define a ∗-representation

π
0

\pi_{0}

of

O
q

A
0

⁢

[
K
]

\mathcal{O}_{q}^{{\mathbf{A}_{0}}}[K]

.
We show that the resulting ∗-algebra

O
⁢

[

K
0

]

=

π
0

⁢

(

O
q

A
0

⁢

[
K
]

)

\mathcal{O}[K_{0}]=\pi_{0}(\mathcal{O}_{q}^{{\mathbf{A}_{0}}}[K])

is a Kumjian–Pask algebra, in the sense of Aranda Pino, Clark, an Huef and Raeburn.
We give an explicit description of the underlying higher-rank graph in terms of crystal basis theory.
As a consequence, we obtain a continuous field of

C
*

C^{*}

-algebras

(

C
⁢

(

K
q

)

)

q
∈

[
0
,
∞
]

(C(K_{q}))_{q\in[0,\infty]}

, where the fibres at

q
=
0

q=0

and ∞ are explicitly defined higher-rank graph algebras.
An Establishment of Ulaanbaatar as a Buddhist Settlement
Authors: Munkhuu Bilegsaikhan , Sukhragchaa Amarjargal , Navaansuren Enkhtuya , Badarch Lkhamtseden 
Published: August 2023

Abstract
This article relies on historical geography method to explain why the ancient Buddhist settlements in Mongolia moved while bringing their belongings, how Buddhism and the surrounding events affected the settlement, and what happened to the settlement after the migration ended. The establishment of religious communities, their customs, traditions and teachings have significantly influenced on the shift from a nomadic to an urbanized ‘mindset’ and a way of living. Subsequently, this laid the basis of Ulaanbaatar’s social economic, and cultural relations. As a result of studies, we came to conclusion that Ulaanbaatar’s chronology need to be calculated starting in 1778 thanks to the advantages brought about by the religious settlements extended stay in one location.
Sprint Interval Training on Stationary Air Bike Elicits Cardiorespiratory Adaptations While Being Time-Efficient
Authors: Moghaddam Masoud , Cervantes Mason , Cheshier Brandie , Jacobson Bert H. 
Published: August 2023

Abstract
Moghaddam, M, Cervantes, M, Cheshier, B, and Jacobson, BH. Sprint interval training on stationary air bike elicits cardiorespiratory adaptations while being time-efficient. J Strength Cond Res 37(9): 1795–1801, 2023—Sprint interval training (SIT) refers to a set of brief intermittent exercises that are performed at maximal intensity. This study compared the effects of 2 SIT protocols (e.g., 10-5-SIT and 20-10-SIT) vs. moderate-intensity continuous training (MICT) on cardiovascular adaptations, using stationary air bikes. Thirty-two recreationally active individuals were randomly assigned to the 3 performance groups, such as 10-5-SIT (n = 11), 20-10-SIT (n = 10), and MICT (n = 11), to train 3 days per week for 4 weeks. Moderate-intensity continuous training included 30 minutes of cycling at 75% of maximal heart rate reserve, whereas the SIT protocols consisted of 3 sets of 8 intervals at all-out intensity. The 10-5-SIT and 20-10-SIT were performed with 10-second work:5-second rest and 20-second work:10-second rest, with 2.5- and 5-minute recovery periods between sets, respectively. A ramp protocol was used before and after the intervention via cycle ergometer to assess aerobic performance. Time to exhaustion (TTE), absolute V̇o
2max (A-V̇o
2max), relative V̇o
2max (R-V̇o
2max), and metabolic equivalents (METs) were measured and analyzed with 2-way mixed factorial analyses of variance (ANOVAs). In addition, total work (TW) during 12 sessions were recorded and analyzed with 1-way ANOVA. Significant (p < 0.05) differences were found for TW (10-5-SIT: 907.3 ± 332.0, 20-10-SIT: 1230.0 ± 188.1, and MICT: 2263.0 ± 896.9 calories) between groups. A significant main effect of time was observed for 10-5-SIT, 20-10-SIT, and MICT (p < 0.05) in TTE (increased by 7.3, 8.7, and 8.2%), A-V̇o
2max (increased by 13.0, 11.8, and 13.6%), R-V̇o
2max (increased by 12.6, 12.1, and 14.8%), and METs (increased by 12.7, 12.3, and 14.9%), respectively. Despite less volume and duration, both SIT protocols induced cardiorespiratory adaptations similar to MICT. These findings suggest that performing SIT on a stationary air bike is valuable because of time-efficiency and cardiorespiratory adaptations.
Toward a New Conceptual Approach to “Intensity” in Soccer Player's Monitoring: A Narrative Review
Authors: Pillitteri Guglielmo , Clemente Filipe M. , Petrucci Marco , Rossi Alessio , Bellafiore Marianna , Bianco Antonino , Palma Antonio , Battaglia Giuseppe 
Published: August 2023

Abstract
Pillitteri, G, Clemente, FM, Petrucci, M, Rossi, A, Bellafiore, M, Bianco, A, Palma, A, and Battaglia, G. Toward a new conceptual approach to “intensity” in soccer player's monitoring: A narrative review. J Strength Cond Res 37(9): 1896–1911, 2023—In the last decade, monitoring physiological and match-related demands in soccer has become an increasingly common practice in sports sciences. One of the great challenges during monitoring process is the identification of key indicators that permit to generalize evidence and sustain decision-making process during training prescription. Actually, one of the major debates in the scientific community and among practitioners is the identification of the “intensity” concept. Defining a given training session or exercise based on “intensity” is difficult due to the fact that a huge amount of indicators are available (related both to the performed activities and to the athletes' psychophysiological responses). These indicators can lead to specific outcomes with different interpretations. The current narrative review aims to discuss the different measures approaches used in soccer to describe the intensity for both internal and external demands. In addition, a second purpose of this review is to propose general recommendations for combining intensity indicators with the aim of defining an overall intensity score of a training session or drill.