bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prenatal detection of aortic coarctation in a well‐organized screening setting: Are we there yet?
Authors: Zwanenburg Fleur , Ten Harkel Arend D. J. , Snoep Maartje C. , Bet Bo B. , Linskens Ingeborg H. , Knobbe Ingmar , Pajkrt Eva , Blom Nico A. , Clur Sally‐Ann B. , Haak Monique C. 
Published: December 2022

AbstractObjectiveWe aimed to assess current prenatal detection rate (DR) of aortic coarctation (CoA) and its impact on neonatal outcome in the Netherlands to evaluate the efficacy of the Dutch screening protocol in which the cardiac four‐chamber view, outflow tracts and three‐vessel view are compulsory.MethodsAll prenatally and postnatally diagnosed CoA cases between 2012 and 2021 were extracted from our PRECOR‐registry. Annual DRs were calculated with a focus on the trend over time and attributing factors for detection. Postnatal outcome was compared between prenatally detected and undetected cases.Results49/116 cases (42.2%) were detected prenatally. A higher chance of detection was found for cases with extracardiac malformations (71.4%; p = 0.001) and the more severe cases with an aortic arch hypoplasia and/or ventricular septal defect (63.2%; p = 0.001). Time‐trend analysis showed no improvement in DR over time (p = 0.33). Undetected cases presented with acute circulatory shock in 20.9% and were more likely to have severe lactic acidosis (p = 0.02) and impaired cardiac function (p < 0.001) before surgery.ConclusionEven in a well‐organized screening program, the DR of CoA still requires improvement, especially in isolated cases. The increased risk of severe lactic acidosis in undetected cases stresses the need for urgent additions to the current screening program, such as implementation of the three‐vessel trachea view and measurement of outflow tracts.
A Review on Conversion of Biomass to Liquid Fuels and Methanol through Indirect Liquefaction Route
Authors: Gupta Pavan K. , Kumar Vineet , Maity Sudip , Datta Sudipta , Kishore Gupta Goutam 
Published: December 2022

AbstractGlobal urbanization and industrialization are energy‐intensive processes. Among different energy resources, fossil fuels meet more than 80 % of the energy demand. The factors such as the depletion of fossil fuel reserves, the unstable price of fossil fuels, and the emission of greenhouse gases (GHGs) due to the burning of fuels draw researchers’ attention towards the development of renewable and sustainable fuels. In this context, biomass may fill the gap between energy demand and petroleum availability in the foreseeable future. Moreover, half of this bioenergy comes from conventional uses of biomass, primarily in cooking and heating, as well as within small‐scale industries (such as charcoal kilns and brick kilns). The Biomass‐to‐Liquid (BTL) technology using Fischer‐Tropsch synthesis (FTS) and the Methanol process offers advantages over the traditional use of biomass. The FT/Methanol process is a propitious route to produce carbon‐neutral, ultra‐clean fuels that generate regulated emissions, including NOx, SOx, and PM. In this article, we have reviewed the processes of biomass gasification, syngas cleaning and conditioning, FTS and methanol synthesis.
Exquisite use of Selenoesters as Recyclable Acyl Donors for Lipases‐catalyzed Kinetic Resolution
Authors: Zugman Tay , da Silva Durigon Maria Clara , Campos Suelem Kluconski , da Silva Rodolfo Rodrigues , da Silva Thiago Sabino , de Oliveira Alfredo Ricardo Marques , Piovan Leandro 
Published: December 2022

AbstractLipase‐catalyzed enantioselective synthetic reactions employing enol esters, activated esters, anhydrides, and oximes as acyl donors is a well‐consolidated strategy towards enantiopure compounds. However, lipases can also cleave the C−S bond of thioesters, proving that other classes of substances can be used as acyl donors in lipase‐catalyzed transformations. Herein we describe the application of selenoesters as a new class of acyl donors in enzymatic kinetic resolution of chiral alcohols. A series of selenoesters was successfully employed in the resolution of chiral primary and secondary alcohols, demonstrating that lipases can also cleave the C−Se bond. Assays using selenoesters as acyl donors in lipase‐catalyzed reactions furnished enantiopure compounds (e.e.>99 %) and enantiomeric ratio (E>200). We also observed that the enzymatic reaction is accelerated in an oxygen atmosphere and performing a preparative scale reaction could demonstrate how simple and easy the purification process is to recover the diselenide formed during the resolution.
Copper Mediated Direct Amination: Synthesis of 1,2,3,15 a‐tetrahydro‐14H‐pyrrolo[1,2‐a]quinazolino[3,2‐c]quinazolin‐14‐onederivatives via 2‐(2‐bromophenyl)quinazolin‐4(3H)‐ones
Authors: Reddy Potuganti Gal , Kandula Aravind , Vashishtha Kirti , Reddy Indukuri Divakar , Alla Manjula 
Published: December 2022

AbstractA convenient one pot method developed for synthesisof fused pyrroloquinazolinone and amino quinazolinone derivatives starting from 2‐bromo benzaldehyde, anthranilamide through in situ formation of2‐(2‐bromophenyl)quinazolin‐4(3H)‐one and subsequent reaction withdifferent amino acids/cyclic secondary amines under aerobic conditions. The multicomponent protocol mediated by copper (II) salt involves direct amination with 2‐(2‐bromophenyl)quinazolin‐4(3H)‐one, decarboxylation and cyclization to obtain polycyclic fused quinazolinone or aminated quinazolinone derivatives with the acceptable yields.
Silk fibroin hydrogels for biomedical applications
Authors: Zhang Hui , Xu Dongyu , Zhang Yong , Li Minli , Chai Renjie 
Published: December 2022

AbstractSilk fibroin hydrogels occupy an essential position in the biomedical field due to their remarkable biological properties, excellent mechanical properties, flexible processing properties, as well as abundant sources and low cost. Herein, we introduce the unique structures and physicochemical characteristics of silk fibroin, including mechanical properties, biocompatibility, and biodegradability. Then, various preparation strategies of silk fibroin hydrogels are summarized, which can be divided into physical cross‐linking and chemical cross‐linking. Emphatically, the applications of silk fibroin hydrogel biomaterials in various biomedical fields, including tissue engineering, drug delivery, and wearable sensors, are systematically summarized. At last, the challenges and future prospects of silk fibroin hydrogels in biomedical applications are discussed.
Capturing and Quantifying Particle Transcytosis with Microphysiological Intestine‐on‐Chip Models
Authors: Delon Ludivine C. , Faria Matthew , Jia Zhengyang , Johnston Stuart , Gibson Rachel , Prestidge Clive A. , Thierry Benjamin 
Published: December 2022

AbstractUnderstanding the intestinal transport of particles is critical in several fields ranging from optimizing drug delivery systems to capturing health risks from the increased presence of nano‐ and micro‐sized particles in human environment. While Caco‐2 cell monolayers grown on permeable supports are the traditional in vitro model used to probe intestinal absorption of dissolved molecules, they fail to recapitulate the transcytotic activity of polarized enterocytes. Here, an intestine‐on‐chip model is combined with in silico modeling to demonstrate that the rate of particle transcytosis is ≈350× higher across Caco‐2 cell monolayers exposed to fluid shear stress compared to Caco‐2 cells in standard “static” configuration. This relates to profound phenotypical alterations and highly polarized state of cells grown under mechanical stimulation and it is shown that transcytosis in the microphysiological model is energy‐dependent and involves both clathrin and macropinocytosis mediated endocytic pathways. Finally, it is demonstrated that the increased rate of transcytosis through cells exposed to flow is explained by a higher rate of internal particle transport (i.e., vesicular cellular trafficking and basolateral exocytosis), rather than a change in apical uptake (i.e., binding and endocytosis). Taken together, the findings have important implications for addressing research questions concerning intestinal transport of engineered and environmental particles.
Synthesis, characterization and catalytic activities of Zn(II) and Cd(II) complexes supported by unsymmetrical aryl thiourea ligands
Authors: Banerjee Indrani , Bhattacharjee Jayeeta , Kumar Ravi , Pal Kuntal , Panda Tarun K. 
Published: December 2022

AbstractWe report a series of Zn(II) and Cd(II) metal complexes [L12(ZnCl2)] (1), [L12(ZnBr2)] (2), [L12(CdCl2)] (3), [L12(CdI2)] (4), [L22(ZnCl2)] (5), [L22(ZnBr2)] (6), [L22(ZnI2)] (7), [L22(CdCl2)] (8), [L32(CdCl2)] (9) and [L42(ZnBr2)] (10), synthesized using various unsymmetrical aryl thiourea ligands: 1‐(2,6‐diisopropylphenyl)‐3‐phenylthiourea (L1), 1‐mesityl‐3‐phenylthiourea (L2), 1‐(2‐fluorophenyl)‐3‐phenylthiourea (L3) and symmetrical 1,3‐bis(2‐fluorophenyl)thiourea (L4). The ligands and metal complexes were characterized by1H,13C{1H} NMR, FT‐IR analysis. Solid‐state structures of the zinc and cadmium metal complexes (1–8) were established using the single‐crystal diffraction analysis technique. Furthermore, the catalytic activities of the Zn(II) complexes towards hydroboration of aldehydes and ketones (‐C=O) as substrates were studied. Excellent yields of the corresponding boronate esters were achieved.
Synthesis of Donor‐Stabilized Organogallium Complexes En Route to a Gallene
Authors: Bourque Jeremy L. , Baines Kim M. 
Published: December 2022

AbstractThe synthesis of a compound with a gallium‐carbon double bond, a gallene, was targeted. A series of organogallium compounds stabilized by an N‐heterocyclic carbene, 1,3‐diisopropyl‐4,5‐dimethyl‐imidazol‐2‐ylidene (MeIiPr) or 4‐dimethylaminopyridine (DMAP) was synthesized from Li[GaCl2FlMes] (1; Mes=2,4,6‐trimethylphenyl, Fl=fluorenyl), including MeIiPr→GaClFlMes (3) and DMAP→GaClFlMes (4) and their triflate (7, 9, respectively) and fluoride (8, 10, respectively) derivatives through pseudohalide exchange or nucleophilic substitution at the gallium centre. Treatment of 8 with tBuLi followed by the addition of tolualdehyde gave 11, a 1‐galla‐2,6‐dioxacyclohexane which can reasonably be formed by the sequential addition of two equivalents of the aldehyde to a transient gallene, a compound containing a Ga−C double bond.
Identifying optimal candidates for post-TIPS patients with HCC undergoing TACE: a multicenter observational study
Authors: Fan Wenzhe , Zhu Bowen , Yue Shufan , Zheng Xinlin , Yuan Guosheng , Yu Lei , Huang Wanchang , Huang Shugui , Wei Wenjiang , Li Fuliang , Huang Zhen , Tang Rong , Fan Huishuang , Li Zhuoyong , Qiao Liangliang , Huang Fuxi , Cheng Yu , Zhang Yingqiang , Wu Yanqin , Zou Xinhua , Xue Miao , Wang Hongyu , Li Jiaping 
Published: December 2022

Abstract
Objective
To develop a prognostic model for post-transjugular intrahepatic portosystemic shunt (TIPS) patients with hepatocellular carcinoma (HCC) beyond the Milan criteria treated by transarterial chemoembolization (TACE).

Design
Between January 2013 and January 2020, 512 patients with HCC beyond the Milan criteria who underwent TACE after TIPS were retrospectively recruited from 15 tertiary centers. Patients were randomly sorted into a training set (n = 382) and a validation set (n = 130). Medical data and overall survival were assessed. A prediction model was developed using multivariate Cox regression analyses. Predictive performance and discrimination were evaluated and compared with other prognostic models.

Results
Vascular invasion, log10(AFP), 1/creatinine, extrahepatic spread, and log10(ALT) were the most significant prognostic factors of survival. These five parameters were included in a new VACEA score. This score was able to stratify patients in the training set into four distinct risk grades whose median overall survival were 25.2, 15.1, 8.9, and 6.2 months, respectively. The 6-month, 1-year, 2-year, and 3-year AUROC values and C-index of the VACEA model were 0.819, 0.806, 0.779, 0.825, and 0.735, respectively, and higher than those of other seven currently available models in both the training and validation sets, as well as in different subgroups.

Conclusion
The VACEA score could stratify post-TIPS patients with HCC beyond the Milan criteria treated by TACE and help to identify candidates who benefit from this treatment.

Key Points
• Vascular invasion, AFP, creatinine, extrahepatic spread, and ALT were independent significant prognostic factors of survival for HCC patients who underwent TACE after TIPS.
• Our new model, named VACEA score, can accurately predict prognosis at the individual level and stratify patients into four distinct risk grades.
• The VACEA model showed better prognostic discrimination and calibration than other current TACE-/TIPS-specific models
Recent advances and challenges in potato improvement using CRISPR/Cas genome editing
Authors: Chincinska Izabela Anna , Miklaszewska Magdalena , Sołtys-Kalina Dorota 
Published: December 2022

Abstract
Main conclusion
Genome editing using CRISPR/Cas technology improves the quality of potato as a food crop and enables its use as both a model plant in fundamental research and as a potential biofactory for producing valuable compounds for industrial applications.

Abstract
Potato (Solanum tuberosum L.) plays a significant role in ensuring global food and nutritional security. Tuber yield is negatively affected by biotic and abiotic stresses, and enzymatic browning and cold-induced sweetening significantly contribute to post-harvest quality losses. With the dual challenges of a growing population and a changing climate, potato enhancement is essential for its sustainable production. However, due to several characteristics of potato, including high levels of heterozygosity, tetrasomic inheritance, inbreeding depression, and self-incompatibility of diploid potato, conventional breeding practices are insufficient to achieve substantial trait improvement in tetraploid potato cultivars within a relatively short time. CRISPR/Cas-mediated genome editing has opened new possibilities to develop novel potato varieties with high commercialization potential. In this review, we summarize recent developments in optimizing CRISPR/Cas-based methods for potato genome editing, focusing on approaches addressing the challenging biology of this species. We also discuss the feasibility of obtaining transgene-free genome-edited potato varieties and explore different strategies to improve potato stress resistance, nutritional value, starch composition, and storage and processing characteristics. Altogether, this review provides insight into recent advances, possible bottlenecks, and future research directions in potato genome editing using CRISPR/Cas technology.
Longitudinal associations between digital media use and ADHD symptoms in children and adolescents: a systematic literature review
Authors: Thorell Lisa B. , Burén Jonas , Ström Wiman Johanna , Sandberg David , Nutley Sissela B. 
Published: December 2022

AbstractPrevious reviews have often shown a link between digital media ADHD symptom levels. However, longitudinal studies are needed to find stronger evidence of a causal effect as well as to determine the direction of effects. The aim of the present review (PROSPERO CRD42021262695) was therefore to provide a systematic review of studies meeting the following inclusion criteria: (1) include longitudinal data investigating associations between digital media (i.e., gaming and social media) and later ADHD symptoms or vice versa, (2) be published within the past 10 years (i.e., 2011 until June 2021), (3) be published in a peer-reviewed journal in English, and (4) include children or adolescents (age 0–17 years). After a systematic search in the Web of Science and PsycInfo databases, we included 28 studies, all with adequate or high quality. Results showed support for reciprocal associations between digital media and ADHD symptoms, with associations being more consistent for problematic use of digital media than for screen time. Thus, children with ADHD symptoms appear more vulnerable to developing high or problematic use of digital media (i.e., selection effects), and digital media also have effects on later ADHD symptom levels, either because of specific characteristics of digital media or because of indirect effects on, for example, sleep and social relations (i.e., media effects). However, it should be emphasized that further studies investigating potential moderators and mediators are needed if we are to better understand the complex associations between digital media and ADHD symptom levels.
Correlation of aluminum doping and lithiation temperature with electrochemical performance of LiNi1-xAlxO2 cathode material
Authors: Välikangas Juho , Laine Petteri , Hietaniemi Marianna , Hu Tao , Selent Marcin , Tynjälä Pekka , Lassi Ulla 
Published: December 2022

Abstract
This article presents a process for producing LiNi1-xAlxO2 (0 <  ×  < 0.05) cathode material with high capacity and enhanced cycle properties of 145 mAh/g after 600 cycles. The LiNi1-xAlxO2 (0 <  ×  < 0.05) cathode material is prepared by mixing coprecipitated Ni(OH)2 with LiOH and Al(OH)3, followed by lithiation at temperature range of 650–710 °C, after which any residual lithium from lithiation is washed from the particle surfaces. Electrochemical performance was studied within full-cell and half-cell application; in addition, different material characterization methods were carried out to explain structure changes when certain amount of aluminum is introduced in the LiNi1-xAlxO2 structure. Surface analyses were carried out to demonstrate how washing process changes the chemical environment of the LiNi1-xAlxO2 secondary particle surface. The results demonstrate how Al doping, lithiation temperature, and the washing process affect the performance of the LiNi1-xAlxO2 cathode material.
Photobiomodulation enhanced endogenous pain modulation in healthy volunteers
Authors: Oono Yuka , Kono Ryoko , Kiyohara Yuki , Takagi Saori , Ide Yasuo , Nagasaka Hiroshi , Kohase Hikaru 
Published: December 2022

AbstractTo examine the effects of photobiomodulation (PBM) in healthy volunteers using photonic stimulation of acupuncture points on conditioned pain modulation (CPM), temporal summation of pain (TSP), and offset analgesia (OA), which reflect some aspects of endogenous pain modulation. We included 15 men and 15 women (age, 31.5 [27.3–37.0], body mass index, 25.7 [24.4–27.1], Fitzpatrick skin typing, II: 20, III: 8, IV: 2). CPM, TSP, and OA were evaluated after a sham procedure (control session) and after acupuncture point stimulation (LI4 and LI10 on the non-dominant forearm) using linear polarized near-infrared light irradiation (LPNILI; wavelengths peaked at approximately 1000 nm, output: 1.4 W/cm2, spot diameter: 10 mm, spot size: 1.02 cm2, maximum temperature: 40.5 °C, pulse width: 1 s, frequency: 0.2 Hz) (PBM session). Differences in CPM, TSP, and OA between the two sessions were evaluated by the paired t-test and Fisher’s exact test (statistical significance: p < 0.05). Values indicate median [interquartile range]. LPNILI significantly increased CPM in all participants (control session: 12.1 [−4.5–37.4], PBM session: 23.9 [8.3–44.8], p < 0.05) and women (control session: 16.7 [−3.4–36.6], PBM session: 38.7 [24.6–52.1], p < 0.05). The CPM effect increment was significantly higher in women than in men (p = 0.0253). LPNILI decreased TSP in participants with higher TSP ratios (p = 0.0219) and increased OA in participants with lower OA scores (p = 0.0021). LPNILI enhanced endogenous pain modulation in healthy volunteers, particularly in women, as evaluated using CPM. CPM, TSP, and OA evaluations are potentially useful for discriminating PBM responders from non-responders.
Epistemology in Practice: Ernst Mach’s Experiments on Shock Waves and The Place of Philosophy
Authors: Guzzardi Luca 
Published: December 2022

AbstractThe present paper studies Ernst Mach’s experimental work with “spark waves” and other types of shock waves, which brought him to the 1887–88 famous schlieren photographs of supersonic phenomena triggered by bullets shot at high speed. Against what it is traditionally argued, I show (1) that Ernst Mach’s visualization attempts do not depend on his commitment to any particular philosophical doctrine about the role of sensations as the foundation of empirical science, and (2) that his inclination toward experimental research may have crucially contributed to the development of his epistemological and ontological views.
Observation and research of deep underground multi-physical fields—Huainan −848 m deep experiment
Authors: Wang Yun , Yang Yaxin , Sun Heping , Xie Chengliang , Zhang Qisheng , Cui Xiaoming , Chen Chang , He Yongsheng , Miao Qiangqiang , Mu Chaomin , Guo Lianghui , Teng Jiwen 
Published: December 2022

AbstractCompared with the surface, the deep environment has the advantages of allowing “super-quiet and ultra-clean”-geophysical field observation with low vibration noise and little electromagnetic interference, which are conducive to therealization of long-term and high-precision observation of multi-physical fields, thus enabling the solution of a series of geoscience problems. In the Panyidong Coal Mine, where there are extensive underground tunnels at the depth of 848 m belowsea level, we carried out the first deep-underground geophysical observations, including radioactivity, gravity, magnetic, magne-totelluric, background vibration and six-component seismic observations. We concluded from these measurements that (1) the background of deep subsurface gravity noise in the long-period frequency band less than 2 Hz is nearly two orders ofmagnitude weaker than that in the surface observation environment; (2) the underground electric field is obviously weaker thanthe surface electric field, and the relatively high frequency of the underground field, greater than 1 Hz, is more than two orders of magnitude weaker than that of the surface electric field; the east-west magnetic field underground is approximately the same asthat at the surface; the relatively high-frequency north-south magnetic field underground, below 10 Hz, is at least one order ofmagnitude lower than that at the surface, showing that the underground has a clean electromagnetic environment; (3) in additionto the high-frequency and single-frequency noises introduced by underground human activities, the deep underground spacehas a sig-nificantly lower background vibration noise than the surface, which is very beneficial to the detection of weakearthquake and gravity signals; and (4) the underground roadway support system built with ferromagnetic material interferesthe geomagnetic field. We also found that for deep observation in the “ultra-quiet and ultra-clean” environment, the existinggeophysical equipment and observation technology have problems of poor adaptability and insufficient precision as well asdata cleaning problems, such as the effective separation of the signal and noise of deep observation data. It is also urgent tointerpret and comprehensively utilize these high-precision multi-physics observation data.