bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spike- and nucleocapsid-based gold colloid assay toward the development of an adhesive bandage for rapid SARS-CoV-2 immune response detection and screening
Authors: Boumar Imen , Deliorman Muhammedin , Sukumar Pavithra , Qasaimeh Mohammad A. 
Published: June 2023

AbstractImmunoglobulin M (IgM) and immunoglobulin G (IgG) antibodies are important biomarkers used for the diagnosis and screening of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections in both symptomatic and asymptomatic individuals. These antibodies are highly specific to the spike (S) and nucleocapsid (N) proteins of the SARS-CoV-2 virus. This paper outlines the development steps of a novel hybrid (vertical-lateral-vertical) flow assay in the form of a finger-stick point-of-care device, similar to an adhesive bandage, designed for the timely detection and screening of IgM and IgG immune responses to SARS-CoV-2 infections. The assay, comprising a vertically stacked plasma/serum separation membrane, conjugate pad, and detection (readout) zone, utilizes gold nanoparticles (AuNPs) conjugated with SARS-CoV-2 S and N proteins to effectively capture IgM and IgG antibodies from a pinprick (~15 µL) of blood in just one step and provides results of no immune IgM−/IgG−, early immune IgM+/IgG−, active immune IgM+/IgG+ or immune IgM−/IgG+ in a short amount of time (minutes). The adhesive bandage-like construction is an example of the design of rapid, low-cost, disposable, and easy-to-use tests for large-scale detection and screening in households. Furthermore, the bandage can be easily adjusted and optimized to detect different viral infections as they arise by simply selecting appropriate antigens related to pandemics and outbreaks.
A Comprehensive dataset for Australian mine production 1799 to 2021
Authors: Mudd Gavin M. 
Published: June 2023

AbstractGiven that metals, minerals and energy resources extracted through mining are fundamental to human society, it follows that accurate data describing mine production are equally important. Although there are often national statistical sources, this typically includes data for metals (e.g., gold), minerals (e.g., iron ore) or energy resources (e.g., coal). No such study has ever compiled a national mine production data set which includes basic mining data such as ore processed, grades, extracted products (e.g., metals, concentrates, saleable ore) and waste rock. These data are crucial for geological assessments of mineable resources, environmental impacts, material flows (including losses during mining, smelting-refining, use and disposal or recycling) as well as facilitating more quantitative assessments of critical mineral potential (including possible extraction from tailings and/or waste rock left by mining). This data set achieves these needs for Australia, providing a world-first and comprehensive review of a national mining industry and an exemplar of what can be achieved for other countries with mining industry sectors.
County augmented transformer for COVID-19 state hospitalizations prediction
Authors: Er Siawpeng , Yang Shihao , Zhao Tuo 
Published: June 2023

AbstractThe prolonged COVID-19 pandemic has tied up significant medical resources, and its management poses a challenge for the public health care decision making. Accurate predictions of the hospitalizations are crucial for the decision makers to make informed decision for the medical resource allocation. This paper proposes a method named County Augmented Transformer (CAT). To generate accurate predictions of four-week-ahead COVID-19 related hospitalizations for every states in the United States. Inspired by the modern deep learning techniques, our method is based on a self-attention model (known as the transformer model) that is actively used in Natural Language Processing. Our transformer based model can capture both short-term and long-term dependencies within the time series while enjoying computational efficiency. Our model is a data based approach that utilizes the publicly available information including the COVID-19 related number of confirmed cases, deaths, hospitalizations data, and the household median income data. Our numerical experiments demonstrate the strength and the usability of our model as a potential tool for assisting the medical resources allocation.
Enhancement in mechanical and antimicrobial properties of epoxidized natural rubber via reactive blending with chlorhexidine gluconate
Authors: Kanthiya Thidarat , Thajai Nanthicha , Chaiyaso Thanongsak , Rachtanapun Pornchai , Thanakkasaranee Sarinthip , Kumar Anbarasu , Boonrasri Siwarote , Kittikorn Thorsak , Phimolsiripol Yuthana , Leksawasdi Noppol , Tanadchangsaeng Nuttapol , Jantanasakulwong Kittisak 
Published: June 2023

AbstractAn epoxidized natural rubber (ENR) blend with chlorhexidine gluconate (CHG) was prepared using a two-roll mill at 130 °C. CHG was added at concentrations of 0.2, 0.5, 1, 2, 5, and 10% (w/w) as an antimicrobial additive. The ENR blend with 10% (w/w) CHG showed the best tensile strength, elastic recovery, and Shore A hardness. The ENR/CHG blend exhibited a smooth fracture surface. The appearance of a new peak in the Fourier transform infrared spectrum confirmed that the amino groups of CHG reacted with the epoxy groups of ENR. The ENR with 10% CHG exhibited an inhibition zone against Staphylococcus aureus. The proposed blending improved the mechanical properties, elasticity, morphology, and antimicrobial properties of the ENR.
Booster effect of the third dose of SARS-CoV-2 mRNA vaccine in Japanese kidney transplant recipients
Authors: Kawabe Mayuko , Kuroda Takafumi , Yamamoto Izumi , Kobayashi Akimitsu , Ohki Yutaro , Hayashi Ayaka , Urabe Fumihiko , Miki Jun , Yamada Hiroki , Kimura Takahiro , Matsuo Nanae , Tanno Yudo , Horino Tetsuya , Ohkido Ichiro , Yamamoto Hiroyasu , Yokoo Takashi 
Published: June 2023

AbstractThe humoral response of kidney transplant recipients (KTR) to the mRNA vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is generally poor. We evaluated the booster effect of the third dose (D3) of two SARS-CoV-2 mRNA vaccines 6 months after the second dose (D2) in Japanese KTR. The anti-spike (anti-S) antibody titer 1 and 3 months after the D3 was evaluated in 82 Japanese KTR. The primary endpoint was the seropositivity rate, and factors associated with the lack of a response were evaluated in a logistic regression model. Overall, the anti-S antibody seropositivity rate 1 and 3 months after the D3 was 74.7% and 76.0%. The anti-S antibody titers after the first and second doses were higher in patients vaccinated with the mRNA-1273 than with the BNT162b2 vaccine. Among the 38 KTR who were seronegative 5 months after the D2, 18 (47.4%) became seropositive following the D3. Factors associated with a non-response were mycophenolic acid dose, post-transplant duration, hemoglobin, and lymphocyte count. A humoral response 1 and 3 months after the D3 was obtained in ~ 75% of KTR, but 20% were non-responders. Additional studies are needed to clarify the factors hindering a vaccine response.
Circulating extracellular vesicle-derived MARCKSL1 is a potential diagnostic non-invasive biomarker in metastatic colorectal cancer patients
Authors: Rong Wenqing , Shao Shiyun , Pu Yunzhou , Ji Qing , Zhu Huirong 
Published: June 2023

AbstractExtracellular vesicle-derived proteins are closely related to colorectal cancer metastasis, and early detection and diagnosis of colorectal cancer metastasis is very important to improve the prognosis. In this study, we evaluated the clinical significance of plasma EV-derived MARCKSL1 in differentiating patients with metastatic and nonmetastatic CRC. This study included 78 patients, including 40 patients with nonmetastatic colorectal cancer, 38 patients with metastatic colorectal cancer, and 15 healthy volunteers. The extracellular vesicles extracted from the participants' plasma were characterized through transmission electron microscopy, nanoparticle tracking analysis and western blotting. MARCKSL1 protein expression in the EVs was detected by ELISA, and the diagnostic efficacy of MARCKSL1 alone or in combination with CA125 and lymphocyte levels was evaluated by receiver operating characteristic curve (ROC) analysis. Pearson's correlation test was performed to detect the correlation between MARCKSL1, CA125, lymphocyte level and clinicopathological characteristics of tumors. The present study demonstrated that the level of circulating EV-derived MARCKSL1 in patients with metastatic colorectal cancer was significantly higher than that in patients with nonmetastatic colorectal cancer and healthy people. Combined with CA125 and lymphocyte levels, the best diagnostic effect was achieved, and the area under the ROC curve was 0.7480. Together, our findings indicated that circulating EV-derived MARCKSL1 could be used as a new potential diagnostic biomarker for metastatic CRC.
Clinical feasibility of CS-VIBE accelerates MRI techniques in diagnosing intracranial metastasis
Authors: Park Sang Ik , Yim Younghee , Chung Mi Sun 
Published: June 2023

AbstractOur objective was to evaluate and compare the diagnostic performance of post-contrast 3D compressed-sensing volume-interpolated breath-hold examination (CS-VIBE) and 3D T1 magnetization-prepared rapid-acquisition gradient-echo (MPRAGE) in detecting intracranial metastasis. Additionally, we analyzed and compared the image quality between the two. We enrolled 164 cancer patients who underwent contrast-enhanced brain MRI. Two neuroradiologists independently reviewed all the images. The signal-to-noise ratio (SNR), contrast-to noise ratio (CNR) were compared between two sequences. For patients with intracranial metastasis, we measured enhancement degree and CNRlesion/parenchyma of the lesion. The overall image quality, motion artifact, gray-white matter discrimination and enhancing lesion conspicuity were analyzed. Both MPRAGE and CS-VIBE showed similar performance in diagnosing intracranial metastasis. Overall image quality of CS-VIBE was better with less motion artifact; however conventional MPRAGE was superior in enhancing lesion conspicuity. Overall, the SNR and CNR of conventional MPRAGE were higher than those of CS-VIBE. For 30 enhancing intracranial metastatic lesions, MPRAGE showed a lower CNR (p = 0.02) and contrast ratio (p = 0.03). MPRAGE and CS-VIBE were preferred in 11.6 and 13.4% of cases, respectively. In comparison with conventional MPRAGE, CS-VIBE achieved comparable image quality and visualization, with the scan time being half of that of MPRAGE.
Controllable hybrid plasmonic integrated circuit
Authors: Khodadadi Maryam , Moshiri Seyyed Mohammad Mehdi , Nozhat Najmeh , Khalily Mohsen 
Published: June 2023

AbstractIn this paper, a controllable hybrid plasmonic integrated circuit (CHPIC) composed of hybrid plasmonic waveguide (HPW)-based rhombic nano-antenna, polarization beam splitter, coupler, filter, and sensor has been designed and investigated for the first time. In order to control the power into a corresponding input port, a graphene-based 1 × 3 power splitter with switchable output has been exploited. The functionality of each device has been studied comprehensively based on the finite element method and the advantages over state-of-the-art have been compared. Moreover, the effect of connection of CHPIC to the photonic and plasmonic waveguides has been studied to exhibit the capability of variety excitation methods of the CHPIC. Furthermore, the performance of the proposed CHPIC connected to inter/intra wireless transmission links has been investigated. The wireless transmission link consists of two HPW-based nano-antennas as transmitter and receiver with the maximum gain and directivity of 10 dB and 10.2 dBi, respectively, at 193.5 THz. The suggested CHPIC can be used for applications such as optical wireless communication and inter/intra-chip optical interconnects.
Veranstaltung des BDDH im Rahmen der 67. Jahrestagung der Gesellschaft für Thrombose- und Hämostaseforschung in Frankfurt
Authors: Sucker Christoph , Koscielny Jürgen 
Published: June 2023

AbstractIm Rahmen der 67. Jahrestagung der Gesellschaft für Thrombose- und Hämostaseforschung (GTH) in Frankfurt veranstaltete der BDDH am 23.2.2022 nach der Mitgliederversammlung eine öffentliche Sitzung zu berufspolitischen Themen. Die Sitzung war sehr gut besucht, wobei neben BDDH- Mitgliedern auch andere interessierte Ärzte und Vertreter der Industrie teilnahmen. In dieser Ausgabe der „BDDH News“ berichten wir über 2 Themenkomplexe aus dieser Sitzung und fassen die gehaltenen Vorträge zusammen.
Parents’ indirect utterances in an Indonesian family
Authors: Setiawan Budi 
Published: June 2023

Abstract
This present study examines Indonesian parents’ utterance to instruct each other. The results show that Indonesian parents’ speeches in the family were situated in context and situation. Parents did not mention themselves nor their spouse as the addressee, instead using indirect utterance to instruct the addressee. They produced indirect utterances with implied meanings, instructing their spouse via speaking to their children or about other objects. Each parent understood their spouse’s intention from the context and physical condition of family members.
Livestock for Livelihoods: Role of Goats in Improving the Livelihood and Well-being of Women Pastoralists in Ethiopia and Uganda
Authors: Adhiambo Onyango Dr Diana 
Published: June 2023

Abstract
Farm Africa worked with semi-nomadic pastoralist women living in the South Omo region of Ethiopia and Karamoja subregion in Uganda, thereby supporting them to set up sustainable, small-scale goat-rearing enterprises that contributed to increased household income, improved dietary diversity and nutritional status of their families. The project also supported community-based animal health service delivery as part of the integrated approach.
Livestock is the main source of livelihood for the pastoralist communities in East Africa, though disease, drought and degraded grasslands make it unproductive. Rural women in pastoralist communities in Ethiopia and Uganda lack nutritional knowledge, financial skills, credit access and a voice in household decision making, which result in them having a low economic status and which contribute to malnutrition. Declining animal health services, due in part to reduced government capacity, exacerbate the challenge of increasing goat productivity. Farm Africa through the Livestock for Livelihoods project (March 2019–July 2021) supported 10,000 women to improve their socio-economic status and improve household nutrition. It supported women beneficiaries to be more economically empowered through access to finance provided by Village Savings and Loans Associations (VSLAs) and facilitated them to be involved in profitable enterprises in the goat value chain (goat breeding, leather tanning and milk value addition). These activities stimulated livelihood diversification and trade, contributing to reduced levels of poverty and malnutrition. Some of the remarkable results include increased revenue that women acquired from the sale of live goats, meat, hides, skins and milk; improved dietary diversity in children under 5 years and women; and increased Women’s Economic Empowerment (WEE) scores. This project created and strengthened a network of Community-Based Animal Health Workers (CAHWs) linked to agro-input dealers to enhance pastoralists’ access to quality animal health services. A total of 155 CAHWs (127 men and 28 women) in the two countries were empowered to provide animal health services to the pastoralists across the project area.

The logo of Farm Africa.

Information
© The Author 2023
The physical determinants of maximal jumping time of flight in elite trampolining
Authors: Dyas Natalie , Green David , Thomas Kevin , Matthew Esme , Howatson Glyn 
Published: June 2023

ABSTRACTTime of flight (ToF) is an objective scoring component of elite trampolining, assessed in training by maximal jump tests. The aim of this study was to assess the relationship between physical floor based performance meaures and 20‐maximum ToF. Thirty‐two elite level gymnasts (13 senior; 19 junior) performed a battery of floor based tests and a 20‐maximum jump test. Floor based tests included cycling peak power output, reactive strength index (RSI), unloaded countermovement jumps (CMJ), and loaded CMJ's to construct a load‐velocity profile for prediction of theoretical maximum force (CMJ F0). Very large and large, positive bivariate relationships were observed between CMJ F0 and ToF for the seniors (r = 0.85) and juniors (r = 0.56), respectively. Very large, positive bivariate relationships were observed between CMJ height and total ToF for both seniors (r = 0.74) and juniors (r = 0.77). Step‐wise multiple regression analyses revealed CMJ F0 predicted 72% of ToF variability between seniors, and CMJ height (59%), 10 to 5 RSI (13%), and CMJ F0 (10%) predicting 82% of ToF variability between juniors. This suggests CMJ F0, lower limb maximal isometric capabilities, and CMJ height are important floor based predictors of maximal ToF in elite gymnasts.
Correlation of H- beam properties to Cs-coverage
Authors: Lettry J. , Vnuchenko A. , Bertolo S. , Mastrostefano C. , O'Neil M. , di Lorenzo F. , Coutron Y. , Steyeart D. , Riffaud B. , Thiboud J. , Guida R. , Kapusniak K. , Charvet C. , Teissandier B. , Moyret P. , Roncarolo F. , Bart Pedersen S. , Duraffourg M. , Vuitton C. , Joffe S. , Machado C. , Fantz U. , Mochalskyy S. , Wunderlich D. , Lindqvist M. , den Harder N. , Briefi S. , Hurlbatt A. , Kalvas T. , Minea T. , Revel A. 
Published: June 2023

Abstract
A caesiated RF driven source delivers H- ions that, after stripping at the end of the 160 MeV H- linear injector, provides protons to CERN's accelerator complex including LHC, where the protons reached a record energy of 6.8 TeV. In Caesiated RF sources, H- ions are produced via dissociative attachment of electrons onto roto-vibrationally excited H2-molecules (volume) and re-emission as negative ions of protons or hydrogen atoms colliding on a low work function caesiated molybdenum plasma electrode (surface). During initial caesiation, the production mechanism evolves from the initial Cs-free volume production to a predominant surface production mode; the observed stunning reduction of co-extracted electrons is concomitant to an increase of the H- ion current to RF-power yield. This paper describes the evolution of the beam-profile at today's operational beam intensities of 35 mA for various ratios of volume and surface ion-origin. The presence of surface produced ions occurring on a conical plane is characterized by the electron to ion ratio and by measurement of the Cs-coverage of the molybdenum plasma electrode down to a fraction of a monolayer. Angular distributions are extracted from beam profile and Beam Emission Spectroscopy (BES) measurements. These experimental results provide an initial comparison to beam formation simulation that, at a later stage, could be coupled to beam transport software packages.

The paper focuses on the caaesiation transient to present experimental evidence for 3D beam formation studies, it provides insight into the mixing of volume and surface production modes, reduction of co-extracted electrons and Cs-coverage. The paper also establishes magnetic field induced asymmetries in the beam's current density.
Chicken utricle stromal cell-derived decellularized extracellular matrix coated nanofibrous scaffolds promote auditory cell production
Authors: Zhang Junming , Li Yuexia , Liu Li , Shen Rong , Lou Xiangxin 
Published: June 2023

Abstract
Stem cell therapy has a broad future in treating sensorineural hearing loss in mammals. But how to produce sufficient functional auditory cells including hair cells, supporting cells as well as spiral ganglion neurons from potential stem cells is the bottleneck. In this study, we aimed to simulate inner ear development microenvironment to induce inner ear stem cells to differentiate into auditory cells. The different mass ratios of poly-l-lactic acid/gelatin (PLLA/Gel) scaffolds were fabricated by electrospinning technology to mimic the structure of the native cochlear sensory epithelium. The chicken utricle stromal cells were isolated and cultured, and then seeded on the PLLA/Gel scaffolds. The chicken utricle stromal cell-derived decellularized extracellular matrix (U-dECM)-coated PLLA/Gel bioactive nanofiber scaffolds (U-dECM/PLLA/Gel) were prepared by decellularization. The U-dECM/PLLA/Gel scaffolds were used for culture of inner ear stem cells, and the effects of the modified scaffolds on the differentiation of inner ear stem cells were analyzed by RT-PCR and immunofluorescent staining. The results showed that U-dECM/PLLA/Gel scaffolds possessed good biomechanical properties can significantly promote the differentiation of inner ear stem cells and make them differentiate into auditory cells. Collectively, these findings indicated that U-dECM-coated biomimetic nanomaterials may be a promising strategy for auditory cell production.
Reconstructing groundwater and lake level histories in Northern Wisconsin: isolation of groundwater’s influence on tree rings from climatic and environmental drivers
Authors: Ciruzzi Dominick M , Loheide II Steven P 
Published: June 2023

Abstract
Tree rings can reveal long-term environmental dynamics and drivers of tree growth. However, individual ecological drivers of tree growth need to be disentangled from the effects of other co-occurring environmental and climatic conditions in tree rings to examine the histories of stand- to landscape-level ecological processes. Here, we integrate ecohydrological theory of groundwater–tree interactions with dendrochronological approaches and develop a new framework to isolate water-level effects on tree rings from climate induced variability in tree ring growth. Our results indicate that changing depth to groundwater within 1–2.3 m of the land surface exerts a substantial influence on red pine growth and this influence can be quantified and used to reconstruct long-term groundwater and lake level histories from tree ring patterns in Northern Wisconsin. This research suggests a substantial influence of groundwater on tree growth with implications for improving the mechanistic understanding of climate-induced tree mortality and reduce uncertainty in forest productivity models. Further, this is a transferable approach to isolate and reconstruct strong environmental drivers of tree growth that co-occur with other environmental signals.