bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring Australian hazard map exceedance using an Atlas of historical ShakeMaps
Authors: Allen Trevor I , Ghasemi Hadi , Griffin Jonathan D 
Published: March 2023

This article explores several area-based tests of long-term seismic hazard forecasts for the Australian continent. Using the observed seismicity, ShakeMaps are calculated for earthquakes that are expected to have generated moderate-to-high levels of ground shaking within continental Australia in the past 50 years (January 1972 through December 2021). A “composite ShakeMap” is generated that extracts the maximum peak ground acceleration “observed” in this 50-year period for any site within the continent. The fractional exceedance area of this composite map is compared with four generations of Australian seismic hazard maps for a 10% probability of exceedance in 50 years (~1/500 annual exceedance probability) developed since 1990. In general, all these models appear to forecast higher seismic hazard relative to the ground motions that are estimated to have occurred in the last 50 years, with the most recent hazard model yielding a fractional exceedance area most similar to the target 1/500 annual exceedance probability. The sensitivity of these results to various modeling assumptions was tested by exploring an alternative ground-motion characterization model that forecasts higher overall ground-shaking intensities. The sensitivity of these results is also tested with the interjection of a rare scenario earthquake with an expected regional recurrence of approximately 8700 years. While these area-based analyses do not provide a robust assessment of the performance of the candidate seismic hazard for any specific location given the limited independent data, they do provide—to the first order—a guide to the performance of the respective maps at a continental scale.
Dynamic Analysis and Parametric Optimization of Telescopic Tubular Mast Applied on Solar Sail
Authors: Ji Chenyang , Liu Jinguo , Wu Chenchen , Zhao Pengyuan , Chen Keli 
Published: March 2023

AbstractLarge-scale solar sails can provide power to spacecraft for deep space exploration. A new type of telescopic tubular mast (TTM) driven by a bistable carbon fiber-reinforced polymer tube was designed in this study to solve the problem of contact between the sail membrane and the spacecraft under light pressure. Compared with the traditional TTM, it has a small size, light weight, high extension ratio, and simple structure. The anti-blossoming and self-unlocking structure of the proposed TTM was described. We aimed to simplify the TTM with a complex structure into a beam model with equal linear mass density, and the simulation results showed good consistency. The dynamic equation was derived based on the equivalent model, and the effects of different factors on the vibration characteristics of the TTM were analyzed. The performance parameters were optimized based on a multiobjective genetic algorithm, and prototype production and load experiments were conducted. The results show that the advantages of the new TTM can complete the deployment of large-scale solar sails, which is valuable for future deep space exploration.
Cultural and economic integration of immigrants in Canada: “Do you play Hockey?”
Authors: Japaridze Irakli , Kaplan Uma 
Published: March 2023

AbstractThis paper studies whether acculturation by immigrants and other minority groups is associated with economic integration in Canada. We examine immigrants’ participation in winter sports, particularly hockey, as a proxy for acculturation given that these sports are popular in Canada but are rarely watched or practiced in the origin countries of many immigrants to Canada. Using the Canadian Community Health Survey, we find that practicing winter sports has a positive effect on the earnings of immigrants and other minority groups. Specifically, practicing winter sports closes the income gap between immigrants and natives. However, the gap does not decrease for visible-minority immigrants, suggesting that acculturation might not be sufficient to combat racial biases.
cnnLSV: detecting structural variants by encoding long-read alignment information and convolutional neural network
Authors: Ma Huidong , Zhong Cheng , Chen Danyang , He Haofa , Yang Feng 
Published: March 2023

Abstract
Background
Genomic structural variant detection is a significant and challenging issue in genome analysis. The existing long-read based structural variant detection methods still have space for improvement in detecting multi-type structural variants.

Results
In this paper, we propose a method called cnnLSV to obtain detection results with higher quality by eliminating false positives in the detection results merged from the callsets of existing methods. We design an encoding strategy for four types of structural variants to represent long-read alignment information around structural variants into images, input the images into a constructed convolutional neural network to train a filter model, and load the trained model to remove the false positives to improve the detection performance. We also eliminate mislabeled training samples in the training model phase by using principal component analysis algorithm and unsupervised clustering algorithm k-means. Experimental results on both simulated and real datasets show that our proposed method outperforms existing methods overall in detecting insertions, deletions, inversions, and duplications. The program of cnnLSV is available at https://github.com/mhuidong/cnnLSV.

Conclusions
The proposed cnnLSV can detect structural variants by using long-read alignment information and convolutional neural network to achieve overall higher performance, and effectively eliminate incorrectly labeled samples by using the principal component analysis and k-means algorithms in training model stage.
Pre-treatment with IL-6 potentiates β-cell death induced by pro-inflammatory cytokines
Authors: Oliveira V. R. , Paula C. C. , Taniguchi S. , Ortis F. 
Published: March 2023

Abstract
Background
Type I Diabetes mellitus (T1D) is characterized by a specific destruction of β-cells by the immune system. During this process pro-inflammatory cytokines are released in the pancreatic islets and contribute for β-cells demise. Cytokine-induced iNOS activation, via NF-κB, is implicated in induction of β-cells death, which includes ER stress activation. Physical exercise has been used as an adjunct for better glycemic control in patients with T1D, since it is able to increase glucose uptake independent of insulin. Recently, it was observed that the release of IL-6 by skeletal muscle, during physical exercise, could prevent β-cells death induced by pro-inflammatory cytokines. However, the molecular mechanisms involved in this beneficial effect on β-cells are not yet completely elucidated. Our aim was to evaluate the effect of IL-6 on β-cells exposed to pro-inflammatory cytokines.

Results
Pre-treatment with IL-6 sensitized INS-1E cells to cytokine-induced cell death, increasing cytokine-induced iNOS and Caspase-3 expression. Under these conditions, however, there was a decrease in cytokines-induced p-eIF2-α but not p-IRE1expression, proteins related to ER stress. To address if this prevention of adequate UPR response is involved in the increase in β-cells death markers induced by IL-6 pre-treatment, we used a chemical chaperone (TUDCA), which improves ER folding capacity. Use of TUDCA increased cytokines-induced Caspase-3 expression and Bax/Bcl-2 ratio in the presence of IL-6 pre-treatment. However, there is no modulation of p-eIF2-α expression by TUDCA in this condition, with increase of CHOP expression.

Conclusion
Treatment with IL-6 alone is not beneficial for β-cells, leading to increased cell death markers and impaired UPR activation. In addition, TUDCA has not been able to restore ER homeostasis or improve β-cells viability under this condition, suggesting that other mechanisms may be involved.
Assessment of Canalis Sinuosus located in maxillary anterior region by using cone beam computed tomography: a retrospective study
Authors: Samunahmetoglu Ercin , Kurt Mehmet Hakan 
Published: March 2023

AbstractBackgroundThe aim of the study is to determine the distribution, location, diameter, and distance measurements of Canalis Sinusosus (CS) in relation with age and sex.Methods300 Cone-Beam Computed Tomography (CBCT) images were evaluated. The distance between CS and nasal cavity floor (NCF), buccal cortical bone margin (BCM), alveolar ridge (AR), respectively.The presence of CS smaller than 1 mm, and the diameter of CS larger than 1 mm were determined. Accessory canals (AC) were classified according to their position relative to the teeth.Results435 CS with a diameter of at least 1 mm and 142 CS < 1 mm were identified. The most frequently observed location of CS was the region of the right central incisors. The mean diameter of the canals ( CS ≥ 1) was 1.31 ± 0.19 on the right side and 1.29 ± 0.17 on the left side. No gender differences were found in canal diameter were observed (p > 0.05). There was no significant difference between men and women in the distance between CS and the NCF on the right side, and a significant difference was found in the distance of CS-NCF on the left side (p = 0.047). There were no significant differences between age groups in all parameters.ConclusionCBCT is a useful tool for identifying CS. Location and diameter of ACs could not be associated with a specific age group or sex.
DCNAS-Net: deformation convolution and neural architecture search detection network for bone marrow oedema
Authors: Song Chengyu , Zhu Shan , Liu Yanyan , Zhang Wei , Wang Zhi , Li Wangxiao , Sun Zhenye , Zhao Peng , Tian Shengzhang 
Published: March 2023

Abstract
Background
Lumbago is a global disease that affects more than 500 million people worldwide. Bone marrow oedema is one of the main causes of the condition and clinical diagnosis is mainly made by radiologists manually reviewing MRI images to determine whether oedema is present. However, the number of patients with Lumbago has risen dramatically in recent years, which has brought a huge workload to radiologists. In order to improve the efficiency of diagnosis, this paper is devoted to developing and evaluating a neural network for detecting bone marrow edema in MRI images.

Related work
Inspired by the development of deep learning and image processing techniques, we design a deep learning detection algorithm specifically for the detection of bone marrow oedema from lumbar MRI images. We introduce deformable convolution, feature pyramid networks and neural architecture search modules, and redesign the existing neural networks. We explain in detail the construction of the network and illustrate the setting of the network hyperparameters.

Results and discussion
The detection accuracy of our algorithm is excellent. And its accuracy of detecting bone marrow oedema reached up to 90.6$$\%$$
%
, an improvement of 5.7$$\%$$
%
compared to the original. The recall of our neural network is 95.1$$\%$$
%
, and the F1-measure also reaches 92.8$$\%$$
%
. And our algorithm is fast in detecting it, taking only 0.144 s per image.

Conclusion
Extensive experiments have demonstrated that deformable convolution and aggregated feature pyramid structures are conducive for the detection of bone marrow oedema. Our algorithm has better detection accuracy and good detection speed compared to other algorithms.
Biopsy-proven first dose of oxaliplatin-induced acute tubular necrosis leading to end-stage renal failure: a case report
Authors: Soma Yu , Kawabe Taiichi , Kitaji Daiyu , Hoshino Kaoru , Sunohara Sumire , Iwano Takehisa , Kawano Naomi 
Published: March 2023

Abstract
Background
Oxaliplatin is an anticancer therapy for pancreatic, gastric, and colorectal cancers. It is also used in patients with carcinomas of unknown primary sites. Oxaliplatin is associated with less frequent renal dysfunction than other conventional platinum-based drugs such as cisplatin. Albeit, there have been several reports of acute kidney injury with frequent use. In all cases, renal dysfunction was temporary and did not require maintenance dialysis. There have been no previous reports of irreversible renal dysfunction after a single dose of oxaliplatin.

Case presentation
Previous reports of oxaliplatin-induced renal injury occurred after patients received multiples doses. In this study, a 75-year-old male with unknown primary cancer and underlying chronic kidney disease developed acute renal failure after receiving the first dose of oxaliplatin. Suspected of having drug-induced renal failure through an immunological mechanism, the patient was treated with steroids; however, treatment was ineffective. Renal biopsy ruled out interstitial nephritis and revealed acute tubular necrosis. Renal failure was irreversible, and the patient subsequently required maintenance hemodialysis.

Conclusions
We provide the first report of pathology-confirmed acute tubular necrosis after the first dose of oxaliplatin which led to irreversible renal dysfunction and maintenance dialysis.
Abdominal fat and muscle distributions in different stages of colorectal cancer
Authors: Han Jun , Liu Xinyang , Tang Min , Yang Fan , Ding Zuoyou , Wu Guohao 
Published: March 2023

Abstract
Background
The purpose of this study is to explore the difference of abdominal fat and muscle composition, especially subcutaneous and visceral adipose tissue, in different stages of colorectal cancer (CRC).

Materials and methods
Patients were divided into 4 groups: healthy controls (patients without colorectal polyp), polyp group (patients with colorectal polyp), cancer group (CRC patients without cachexia), and cachexia group (CRC patients with cachexia). Skeletal muscle (SM), subcutaneous adipose tissue (SAT), visceral adipose tissue (VAT), and intermuscular adipose tissue (IMAT) were assessed at the third lumbar level on computed tomography images obtained within 30 days before colonoscopy or surgery. One-way ANOVA and linear regression were used to analyze the difference of abdominal fat and muscle composition in different stages of CRC.

Results
A total of 1513 patients were divided into healthy controls, polyp group, cancer group, and cachexia group, respectively. In the development of CRC from normal mucosa to polyp and cancer, the VAT area of the polyp group was significantly higher than that of the healthy controls both in male (156.32 ± 69.71 cm2 vs. 141.97 ± 79.40 cm2, P = 0.014) and female patients (108.69 ± 53.95 cm2 vs. 96.28 ± 46.70 cm2, P = 0.044). However, no significant differences were observed of SAT area between polyp group and healthy controls in both sexes. SAT area decreased significantly in the male cancer group compared with the polyp group (111.16 ± 46.98 cm2 vs. 126.40 ± 43.52 cm2, P = 0.001), while no such change was observed in female patients. When compared with healthy controls, the SM, IMAT, SAT, and VAT areas of cachexia group was significantly decreased by 9.25 cm2 (95% CI: 5.39–13.11 cm2, P < 0.001), 1.93 cm2 (95% CI: 0.54–3.32 cm2, P = 0.001), 28.84 cm2 (95% CI: 17.84–39.83 cm2, P < 0.001), and 31.31 cm2 (95% CI: 18.12–44.51 cm2, P < 0.001) after adjusting for age and gender.

Conclusion
Abdominal fat and muscle composition, especially SAT and VAT, was differently distributed in different stages of CRC. It is necessary to pay attention to the different roles of subcutaneous and visceral adipose tissue in the development of CRC.
Protocol for the development and testing of the schiZotypy Autism Questionnaire (ZAQ) in adults: a new screening tool to discriminate autism spectrum disorder from schizotypal disorder
Authors: Parvaiz Rizwan , Vindbjerg Erik , Crespi Bernard , Happe Francesca , Schalbroeck Rik , Al-Sayegh Zainab , Danielsen Ida-Marie , Tonge Bruce , Videbech Poul , Abu-Akel Ahmad 
Published: March 2023

Abstract
Background
Autism spectrum disorder (ASD) and schizotypal disorder (SD) both have a heterogenous presentation, with significant overlaps in symptoms and behaviour. Due to elevated recognition and knowledge of ASD worldwide, there is a growing rate of referrals from primary health professionals to specialised units. At all levels of assessment, the differential diagnostic considerations between ASD and SD exert major challenges for clinicians. Although several validated screening questionnaires exist for ASD and SD, none have differential diagnostic properties. Accordingly, in this study, we aim to develop a new screening questionnaire, the schiZotypy Autism Questionnaire (ZAQ), which provides a combined screening for both conditions, while also indicating the relative likelihood of each.

Methods
We aim to test 200 autistic patients and 100 schizotypy patients recruited from specialised psychiatric clinics and 200 controls from the general population (Phase 1). The results from ZAQ will be compared to the clinical diagnoses from interdisciplinary teams at specialised psychiatric clinics. After this initial testing phase, the ZAQ will be validated in an independent sample (Phase 2).

Conclusions
The aim of the study is to investigate the discriminative properties (ASD vs. SD), diagnostic accuracy, and validity of the schiZotypy Autism Questionnaire (ZAQ).

Funding
Funding was provided by Psychiatric Centre Glostrup, Copenhagen Denmark, Sofiefonden (Grant number: FID4107425), Trygfonden (Grant number:153588), Takeda Pharma.

Trial registration
Clinical Trials, NCT05213286, Registered 28 January 2022, clinicaltrials.gov/ct2/show/NCT05213286?cond = RAADS&draw = 2&rank = 1.
Hydrostatic pressure of the renal pelvis as a radiation-free alternative to fluoroscopic nephrostogram following percutaneous nephrolithotomy
Authors: Dreger Nici Markus , Stapelmann Dominik , Rebacz Patrick , Roth Stephan , Brandt Alexander Sascha , von Rundstedt Friedrich-Carl , Degener Stephan 
Published: March 2023

Abstract
Background
We evaluated the hydrostatic pressure of the renal pelvis (RPP) as a radiation-free alternative to fluoroscopic nephrostogram to assess ureteral patency after percutaneous nephrolithotomy (PCNL).

Methods
Retrospective non-inferiority study analyzing 248 PCNL-patients (86 female (35%) and 162 males (65%)) between 2007 and 2015. Postoperatively, RPP was measured using a central venous pressure manometer in cmH2O. The primary endpoint was to assess RPP depending on the patency of the ureter and the nephrostomy tube removal. Secondary, the upper limit of normal RPP of $$\le$$
≤
20 cmH2O was assessed as an indicator of an unobstructed patency.

Results
The median procedure duration was 141 min (112–171.5) with a stone free rate of 82% (n = 202). RPP was significantly higher in patients with obstructive nephrostogram with 25.0 mmH2O (21.0–32.0) versus 20.0 mmH2O (16.0–24.0; p < 0.001). The pressure was lower in successful nephrostomy removal with 18 cmH2O (15–21) versus 23 cmH2O (20–29) in the leakage group (p < 0.001). The analysis of a cut-off of $$\le$$
≤
20 cmH2O showed a sensitivity of 76.9% (95% CI [60.7%; 88.9%]) and a specificity of 61.5% (95% CI [54.6%; 68.2%]). The negative predictive value was 93.4% (95% CI: [87.9%; 97.0%]) and the positive predictive value 27.3% (95% CI [19.2%; 36.6%]). The accuracy of the model showed an AUC = 0.795 (95% CI [0.668; 0.862]).

Conclusion
The hydrostatic RPP seems to allow a bedside evaluation of ureteral patency after PCNL.
Efficiency of occlusal splint therapy on orofacial muscle pain reduction: a systematic review
Authors: Orzeszek Sylwia , Waliszewska-Prosol Marta , Ettlin Dominik , Seweryn Piotr , Straburzynski Marcin , Martelletti Paolo , Jenca Andrej , Wieckiewicz Mieszko 
Published: March 2023

Abstract
Background
This systematic review aims to examine the existing original studies to determine the effectiveness of occlusal splints (OSs) in the management of orofacial myalgia and myofascial pain (MP) in comparison with no treatment or other interventions.

Materials and methods
Based on the inclusion and exclusion criteria of this systematic review, randomized controlled trials were qualified, in which the effectiveness of occlusal splint therapy in the management of muscle pain was examined in comparison with no treatment or other interventions. This systematic review was conducted according to the guidelines of Preferred Reporting Items for Systematic Reviews and Meta-Analysis 2020. The authors searched three databases (PubMed, CINAHL (The Cumulative Index to Nursing and Allied Health Literature) and Scopus) for English publications published between January 1, 2010, and June 1, 2022. The last database search was carried out on June 4, 2022. Data were extracted from the included studies and assessed for risk of bias using the revised Cochrane risk-of-bias tool for randomized trials.

Results
Thirteen studies were identified for inclusion in this review. In total, 589 patients were diagnosed with orofacial muscle pain who underwent education and various forms of therapy including different types of OSs, light emitting diode therapy, acupuncture, low-level laser therapy, device-supported sensorimotor training, Kinesio Taping, myofunctional therapy, and physical therapy. All studies included demonstrated a high risk of bias.

Conclusions
There is insufficient evidence regarding whether OS therapy in the treatment of orofacial myalgia and MP offers an advantage over other forms of interventions or no treatment. Further reliable clinical studies in this area are needed to improve the quality of research, which should be performed with larger groups of blinded respondents and controls.

Clinical relevance
Due to the large-scale nature of orofacial muscle pain, it is assumed that each dental clinician will meet patients with orofacial muscle pain repeatedly in daily practice; hence, the review of the effectiveness of OSs in the management of orofacial myalgia and MP is necessary.