bluuebunny/crossref_metadata_2025_split huggingface dataset:
Physical Interpretation of the morphology in the relaxation mechanism of Ba Hexagonal Nano-Ferrites (BaCoxCdxFe12-2xO19): Impedance Modelling, AC conductivity, dielectric modulus, and electrical modulus parameters
Authors: Singh Charanjeet , Jain Ankit , Godara Sachin , Jotania Rajshree , Kaur Varinder , Sood Ashwani 
Published: August 2023

Abstract
This study describes in detail the sol-gel synthesis of doped M-type Ba hexagonal ferrite with Co2+ and Cd2+. In order to explore the crystal structure and grain morphology, X-ray diffraction (XRD) and field emission scanning electron microscopy (FESEM) have been used. At room temperature, the dielectric, impedance, electric modulus, and conductivity characteristics were investigated using an impedance analyzer, as well as the physical interpretation of morphology in the relaxation mechanism. The structural parameters indicated the formation of hexagonal M-type crystal structures. Doping with large quantities of Co2+ or Cd2+ caused the unit cell to become smaller, which in turn reduced the lattice constants to lower values. The examination of grain morphology revealed that the doping led to the formation of needle-like grains. The change of AC conductivity from 0.00022 to 1.04*10− 7 Ωm− 1 with frequencies ranging from 1 KHz to 2 MHz demonstrated that the electron hopping process was the primary cause of the high electrical conductivity in these ferrites. As a function of doping, the dielectric spectrum analysis showed that there was a decrease in the dielectric constant and an increase in the loss tangent. Within the frequency range of 1 KHz to 2 MHz, the fluctuation of the dielectric constant (ε′) from 135.94 to 3.59 and the loss tangent (tan σ) from 3.67 to 0.11 was observed. The relaxation of conductivity was seen for different levels of composition, which correlated with the non-Debye type of behaviour proven by the electric modulus spectra. Both relaxation time and AC conductivity decreased with doping. The conductivity relaxation and dielectric relaxation contributed to the charge transport mechanism in the BaCoxCdxFe12−2xO19. Electrochemical impedance spectroscopy software resulted in impedance curves that corresponded with empirically measured impedance values. There was consistency between the calculated grain and grain boundary characteristics as well as the distribution of grains /grain boundaries observed in the micrographs.
RIG-I Promotes Cell Proliferation in Esophageal Squamous Cell Carcinoma by Facilitating p21 Degradation
Authors: Wang Meng , Zhang Yangyang , Gao Liping , Zhang Hailin , Yang Zhenwei , Liu Jialong , Shan Wenqing , Zeng Lingxiu , Zhang Ranran , Li Yong , Liu Jing 
Published: August 2023

Abstract
Background
Retinoic acid-inducible gene-I (RIG-I) is considered a key sensor for host recognition of RNA virus infections. Recent studies have shown that RIG-I also regulates carcinogenesis. However, the role of RIG-I in esophageal squamous cell carcinoma (ESCC) remains unclear.
Method
We investigated the RIG-I expression in ESCC cells using a public database, immunohistochemistry, and Western blotting. We evaluated the proliferative activity of ESCC cells using CCK-8, colony formation, and EdU staining assays. Further, we determined the ESCC cell cycle changes using flow cytometry and the ubiquitination of p21 in the cells using cycloheximide chase and ubiquitination assays. Finally, we verified the in vivo effects of RIG-I on ESCC cells by constructing xenograft models.
Results
RIG-I was highly expressed in ESCC cells and significantly promoted their proliferation and cell cycle. Moreover, RIG-I knockdown inhibited xenograft growth in nude mice. Furthermore, RIG-I accelerated the cell cycle by promoting the ubiquitination and degradation of p21.
Conclusion
Overall, this study revealed that the increased expression of RIG-I due to ESCC accelerated the progression of esophageal cancer by promoting the ubiquitination and degradation of p21, which is related to the prognosis of ESCC. Thus, RIG-I may be a novel therapeutic target for ESCC treatment.
Effect of structured pelvic floor muscle training on pelvic floor muscle contraction and treatment of pelvic organ prolapse in postpartum women: ultrasound and clinical evaluations
Authors: Zhao Hui , Liu Xiu-Ni , Liu Linna 
Published: August 2023

Abstract
Objectives
The purpose of this study is to see how structured pelvic floor muscle training affects pelvic floor muscle contraction and therapy of pelvic organ prolapse (POP) in postpartum women.
Methods
This retrospective study included 60 patients who volunteered for a pelvic floor muscle assessment at 6–8 weeks postpartum. All patients had structured pelvic floor muscle training (PFMT), which included supervised daily pelvic muscle contractions, biofeedback therapy, and twice-week electrical stimulation. The main outcomes were POP stage assessed by POP quantification (POP-Q), pelvic organ position and hiatus area assessed by 3-/4- dimensional transperineal ultrasound, PFM contraction assessed by Modified Oxford scale (MOS), surface electromyography (EMG), and sensation of pelvic muscle graded using a visual analog scale (VAS).
Results
Structured PFMT was associated with better POP-Q scores in Aa, Ba, C, D. The pelvic organ position and hiatus area by 3-/4- dimensional transperineal ultrasound were significantly better than before. PFM contraction assessed by MOS, EMG, and VAS were significantly higher than before. However, no statistically significant differences were observed in improve POP stage.
Conclusions
Postpartum structured PFMT can improve pelvic floor muscle contraction, improve POP-Q scores and elevate the bladder neck, and uterus position. But no effect was found of decreased POP stage. More randomized controlled trials are needed before strong conclusions can be drawn on the effect of structured PFMT on POP in postpartum women.
Clinical efficacy analysis of percutaneous "tripod" combined with radiofrequency ablation and bone cement filling in the treatment of periacetabular metastases
Authors: Yi Chunzhi , Lan Yun , Li Ruoyu , Jiang Linheng , Zhou Nannan , He Mincon , Fang Bin 
Published: August 2023

Abstract
Background： To investigate the clinical efficacy of a percutaneous "tripod" combined with radiofrequency ablation and bone cement filling surgery in treating acetabular bone metastases.
Methods： We retrospectively analyzed 11 patients who underwent percutaneous "tripod" combined with radiofrequency ablation and bone cement filling for acetabular bone metastases at a tertiary care hospital from February 2021 to December 2022.
Results： A total of 11 cases with 13 hips underwent this procedure, including two female patients who underwent both sides, and the rest were unilateral. All cases were followed up for 3 to 24 months, with a mean of 12 months and a median follow-up time of 11 months. By the final follow-up, two of the 11 patients died, and nine survived. One died seven months after surgery, and one died eight months after surgery; the survival of the deceased patients was 7.5 months (range: 7-8 months), with a median survival time of 7.5 months. All 11 patients completed the surgery successfully, and the average unilateral operation time was 167.4 min (148-193). The amelioration of postoperative pain, concomitant with an improvement in the quality of life, was observed in a significant manner, ultimately resulting in a prolonged and sustained effect.
Conclusions： The combination of percutaneous "tripod", radiofrequency ablation, and bone cement filling can effectively relieve pain without delaying the patient's systemic anti-tumor therapy and is a minimally invasive, safe, and effective procedure for the treatment of periacetabular metastases.
High-dose benzodiazepine use and Interval prolongation: a latent class analysis study in a sample of patients using the Verona Detox Approach With Flumazenil
Authors: Zamboni Lorenzo , Portoghese Igor , Casari Rebecca , Fusina Francesca , Santin Laura , Lecca Luigi , Campagnari Simone , Carli Silvia , Zandonai Thomas , Lugoboni Fabio 
Published: August 2023

Abstract
BDZ addiction is a widespread and multifaceted phenomenon. For many patients, especially females, the concomitant use of other drugs also increases their risk of QTc prolongation, possibly leading to complications such as seizures and even sudden death. However, the relationship between BDZ use and QTc prolongation is currently unclear. The present study aims to examine patterns of polysubstance use among a sample of Italian adults with BDZ dependence in relation with their QTc prolongation risk. We used Latent Class Analysis (LCA) on data collected from 251 inpatients of the Addiction Medicine Unit in Verona to group patients into three classes according to their substance use and QTc prolongation risk. Results showed no significant relationship between QTc prolongation and BDZ use in any of the classes considered. We conclude that BDZs, even if used long-term and at high dosages, can be considered safe in terms of cardiovascular complications for patients.
Infection control with antimicrobial solid-state ZnO nanoparticles on silk fibroin gauze
Authors: Vieira Daniela , Dang Cat-Thy , Monk Rachel , Angel Samuel , Marion Alexis , Gbureck Uwe , Harvey Edward , Merle Geraldine 
Published: August 2023

Abstract
Traditional antibiotic treatments for wound infections pose risks associated with microbial resistance, necessitating the exploration of innovative approaches such as nanoparticles as the next generation of antibiotics. In this study, we present a paradigm shift approach for acute and chronic wound care by developing an active wound dressing capable of protecting and eradicating bacteria from the injury site. The focus of this research is on the electroless deposition of large zinc oxide nanoparticles (ZnO NPs) onto spined silk fibroin gauze, targeting a particle size range of approximately 200 nm to minimize cytotoxity. The biocompatibility and antimicrobial efficacy of the ZnO NP-embedded silk wound dressing were evaluated against gram-positive (Staphylococcus aureus) and gram-negative (Pseudomonas aeruginosa) bacteria. The results demonstrate that the ZnO NPs integrated within the silk wound dressing exhibit biocompatibility with 70% cell viability and control microorganism growth against S. aureus and P. aeruginosa, gradually from first 24 hours of exposure. By targeting larger particle size, only the release of a substantial amount of zinc ions were released without generating toxic reactive oxygen species (ROS) that could harm both bacteria and cells. These findings underscore the therapeutic potential of utilizing bioresorbable wound dressings functionalized with large ZnO NPs, thus revolutionizing the landscape of clinical wound care.
Risperidone for the Treatment of Dementia-Related Psychosis: A Systematic Review and Meta-Analysis
Authors: Shan Guangzhen , Yin Suna , Zhang Shubao , Guo Yunfa , Hao Fang 
Published: August 2023

Abstract
Background
Risperidone is one of the atypical antipsychotics that has been used for the treatment of dementia-related psychosis (DRP). However, the findings concerning its efficacy and safety in DRP are contradictory.
Methods
We conducted a systematic review and meta-analysis to address the effects of risperidone on the alleviation of DRP. We searched Medline via PubMed, Scopus, Web of Science, Google Scholar, and PsychINFO from the inception until March 2023. Appropriate statistical tests were used to test the study hypothesis.
Results
The study included 17 articles and 2311 patients with DRP. Risperidone alleviated DRP with a standardized mean difference (SMD) of 0.355 (95%CI, 0.170 to 0.541, p = 0.000). The impact of treatment was positively associated with treatment duration (slope p = 0.038) and dose (slope p = 0.000). Six studies (n = 354) reported the data for the effects of risperidone on cognitive function. Analysis showed that risperidone treatment deteriorated cognitive function in DRP patients with an SMD of -0.185 (95%CI, -0.349 to -0.020, p = 0.028). The heterogeneity of the data was found to be high.
Conclusions
Our meta-analysis provides evidence for the effectiveness of risperidone in the management of DRP. However, because of safety concerns and high data heterogeneity, its use should be individualized for each patient.
A novel filter-based multi-stage parameter estimation for a class of hybrid nonlinear models
Authors: Chen Yanyu , Zhang Xiao , Ding Feng , Xiong Weili 
Published: August 2023

Abstract
Hybird models which combine several different kinds of models together provide effective and flexible structures for modeling time series. Gradient radial basis function based varying-coefficient autoregressive (GRBF-AR) model is a kind of hybrid model which used to describe the nonlinear and nonstationary time series. It has been tested and validated that the GRBF-AR model have good performance in predicting nonlinear and nonstationary time series. This paper presents a novel online parameter estimation method for a class of GRBF-AR models encountered with the colored noise taking account of the ubiquity of colored noise in process control. Aiming to mitigate the disturbance of the colored noise,a filter is designed to whiten the measurement data. With the target of improving the data utilization at every recursion, the multi-innovation identification theory is used to expand the innovation scalar into the innovation vector. By means of the hierarchical identification principle, the whole identification process is divided into several parts to improve the estimation accuracy. In addition, a filter-based multistage multi-innovation generalized extended recursive stochastic gradient algorithm is proposed. Experiment involving two numerical simulations and the prediction for a real world signal are used to validate the performance of the proposed method.
Dental implant rehabilitation in oral cancer patients – evaluation of possible risk factors for implant survival: a retrospective cohort study
Authors: Burtscher Doris , Torre Daniel Dalla 
Published: August 2023

Abstract
Objective: The primary treatment strategy of oral cancer is represented by ablative surgery, often combined to radiochemotherapy. Therefore, oral cancer patients are mostly in the need of dental rehabilitation. Implant procedures play an important role of such rehabilitations despite possible complications related to oncologic treatment and patients’ conditions. The main objective of the present study was the evaluation of survival of dental implants inserted after oncologic treatment of oral cancer patients with additional investigation of possible risk factors.
Material and methods: Data of 38 oral cancer patients, who underwent dental implant rehabilitation with a total of 157 implants inserted after oncologic treatment at the Medical University of Innsbruck from 2008 to 2016, was analyzed retrospectively.
Results: Cumulative 8-year survival rate for all included implants after a mean follow-up of 84 months was 86%. 22 out of 157 implants failed during the observation period, whereby radiotherapy (p=0.007) and maxillary implant insertion (p=0.04) were significantly correlated with a worse implant survival. Tendency of worse outcomes in men and in implants restored with fixed prosthesis were registered, although statistically not significant (p=0.064 resp. p=0.082), whereas chemotherapy didn’t influence implant survival (p=0.607) at all.
Conclusion: The present study confirms promising long-term implant survival in oral cancer patients after oncologic therapy. The main risk factor for implant survival seems to be radiotherapy, which has to be taken into account in implant planning.
Clinical relevance: Given a correct treatment planning, implant rehabilitations seem to be a feasible option for oral cancer patients.
Development and initial assessment of [18F]OP-801: a novel hydroxyl dendrimer PET tracer for preclinical imaging of innate immune activation in the whole body and brain
Authors: Carlson Mackenzie L. , Jackson Isaac M. , Azevedo E. Carmen , Reyes Samantha T , Alam Israt S , Kellow Rowaid , Castillo Jessa B. , Nagy Sydney C , Sharma Rishi , Brewer Matthew , Cleland Jeffrey , Shen Bin , James Michelle 
Published: August 2023

Abstract
Purpose
Innate immune activation plays a critical role in the onset and progression of many diseases. While positron emission tomography (PET) imaging provides a non-invasive means to visualize and quantify such immune responses, most available tracers are not specific for innate immune cells. To address this need, we developed [18F]OP-801 by radiolabeling a novel hydroxyl dendrimer that is selectively taken up by reactive macrophages/microglia and evaluated its ability to detect innate immune activation in mice following lipopolysaccharide (LPS) challenge.
Procedures:
OP-801 was radiolabeled in two steps: [18F]fluorination of a tosyl precursor to yield [18F]3-fluoropropyl azide, followed by a copper-catalyzed click reaction. After purification and stability testing, [18F]OP-801 (150–250 µCi) was intravenously injected into female C57BL/6 mice 24 hours after intraperitoneal administration of LPS (10 mg/kg, n = 14) or saline (n = 6). Upon completing dynamic PET/CT imaging, mice were perfused and radioactivity was measured in tissues of interest via gamma counting or autoradiography.
Results
[18F]OP-801 was produced with > 95% radiochemical purity, 12–52 µCi/µg specific activity, and 4.3 ± 1.5% decay-corrected yield. Ex vivo metabolite analysis of plasma samples (n = 4) demonstrated high stability in mice (97 ± 3% intact tracer > 120 min post-injection). PET/CT images of mice following LPS challenge revealed higher signal in organs known to be inflamed in this context, including liver, lung, and spleen. Gamma counting confirmed PET findings, showing significantly elevated signal in the same tissues compared to saline-injected mice: liver (p = 0.009), lung (p = 0.030), and spleen (p = 0.004). Brain PET/CT images (summed 50–60 min) revealed linearly increasing [18F]OP-801 uptake in whole brain that significantly correlated with murine sepsis score (r = 0.85, p < 0.0001). Specifically, tracer uptake was significantly higher in the brain stem, cortex, olfactory bulb, white matter, and ventricles of LPS-treated mice compared to saline-treated mice (p < 0.05).
Conclusion
[18F]OP-801 is a promising new PET tracer for sensitive and specific detection of activated macrophages and microglia that warrants further investigation.
Design and Verification of the Electric Control Box of the Low Energy X-ray Telescope onboard the Insight-HXMT
Authors: Li Wei , Lu Jingbin , Xu Yupeng , Zhao Xiaofan , Yang Yanji , Cui Weiwei , Chen Yong 
Published: August 2023

Abstract
The Low Energy X-ray telescope (LE) is one of main instruments of the Insight-Hard X-ray Modulation Telescope (Insight-HXMT), which is the first Chinese X-ray astronomical satellite. The scientific objectives of LE focus on the scanning and pointed observations of the X-ray sources in the soft X-ray band (0.7–13 keV). LE is constituted of three detector boxes (LEDs) and an electric control box (LEB). The LEB is composed of data handling unit, monitoring unit and power distribution unit, with the functions of data processing, communication, monitor, power supply and distribution. All the functions designed in the LEB were verified during the operation in orbit. To improve the efficiency of astronomical observations and reliability of LE, onboard data processing is designed in the LEB. The results of onboard data processing are immediately transmitted to the ground as important housekeeping data, and it is verified by comparing with the processing results of the data transmitted to the ground. In the six years since launch, the LEB has performed well and operated smoothly, and all expected requirements have been achieved. The LEB has participated in a number of scientific observations, transmitted a large amount of scientific data, and achieved a number of observational results.
Human Cystic Echinococcosis in The Populations of MENA Countries, With A Focus on The United Arab Emirates, From 1990 To 2019: From Genetic Epidemiology of Rare Disease to Systematic Analysis for the Global Burden of Disease Study 2019
Authors: Rahim Fakher , Qasim Nameer Hashim , Zhumagaliuly Abzal , Dzzhusupov Kenesh 
Published: August 2023

Abstract
This article provides a thorough and methodical evaluation of the Human Cystic Echinococcosis (HCE) burden in the Middle East and North Africa (MENA) area from 1990 to 2019, with a particular focus on the United Arab Emirates (UAE). HCE is prevalent in many places, including MENA, and has a severe public health effect as a zoonotic disease. By analyzing data from the 2019 Global Burden of Disease Study, we were able to calculate the rate of HCE and the number of years of life lost due to it. In 2019, across 21 countries, the three highest number of CE cases were measured in Iran with 5760 (95% UI: 4753 to 6977), in Iraq with 5489 (95% UI: 2905 to 8992), and in Sudan with 5070 (95% UI: 2661to 8432). The largest increase in the number of incident CE cases was seen in UAE (459% increase), Jordan (450% increase), and Afghanistan (234% increase). Moreover, the largest increase in the ASIR of CE was measured was observed in Jordan [EAPC = 2.06%, 95% UI: (1.66–2.47%)], while the greatest reduction was seen in Qatar [EAPC = ‒0.21%, 95% UI: (‒0.36% to ‒0.06%)]. Our research shows that the United Arab Emirates (UAE) and the Middle East are both heavily impacted by HCE. The fact that HCE keeps returning shows that not all bases have been covered in the fight against this illness. The research highlights the need for more focused, resource-optimized measures to tackle HCE, especially in heavily afflicted places like the UAE. To better health outcomes associated with HCE in the MENA area, this report is an essential evidence-based resource for policymakers, healthcare professionals, and academics.
Pheromone of grouped female mice impairs genome stability through stress-mediated pathways
Authors: Glinin Timofey , Petrova Marina , Shcherbinina Veronika , Shubina Anastasia , Dukelskaya Anna , Starshova Polina , Mamontova Victoria , Burnusuz Alexandra , Romashchenko Alexander , Moshkin Mikhail , Khaitovich Philipp , Daev Eugene 
Published: August 2023

Abstract
Population density is known to affect the health and survival of many species, and is especially important for social animals. In mice, living in crowded conditions results in the disruption of social interactions, chronic stress, and immune and reproductive suppression; however, the underlying mechanisms remain unclear. Here, we investigated the role of chemosignals in the regulation of mouse physiology and behavior in response to social crowding. The pheromone 2,5-dimethylpyrazine (2,5-DMP), which is released by female mice in crowded conditions, induced aversion, glucocorticoid elevation and, when chronic, resulted in reproductive and immune suppression. 2,5-DMP olfaction induced genome destabilization in bone marrow cells in a stress-dependent manner, providing a plausible mechanism for crowding-induced immune dysfunction. Interestingly, the genome-destabilizing effect of 2,5-DMP was comparable to a potent mouse stressor (immobilization), and both stressors led to correlated expression changes in genes regulating cellular stress response. Thus, our findings demonstrate that, in mice, the health effects of crowding may be explained at least in part by chemosignals and also propose a significant role of stress and genome destabilization in the emergence of crowding effects.