bluuebunny/crossref_metadata_2025_split huggingface dataset:
Take it or leave it: oophorectomy at the time of benign hysterectomy
Authors: Haber Hilary R. , French Hannah M. , Movilla Peter R. , Isaacson Keith B. , Morris Stephanie N. 
Published: June 2023

Purpose of review
Previous modeling data suggest ovarian conservation up to age 65 for women without adnexal disease and at average risk of ovarian cancer because of an increase in mortality associated with ovarian removal. Recent modeling data challenges this practice. This review of recent literature will update providers regarding consideration for oophorectomy at time of benign hysterectomy.

Recent findings
Oophorectomy at time of hysterectomy for women less than 50 years with estrogen supplementation and greater than 50 years without estrogen supplementation is not associated with increased mortality.

Summary
Although not associated with increased mortality, the decision to remove the ovaries at time of hysterectomy in women older than 50 years is nuanced and requires careful shared decision-making, considering unique patient factors.
The minimally invasive approach to abdominal cerclage: indications, complications, and techniques for placement
Authors: Waters Caitlin , Pinho Gabriella , Kim Sara , Blaber Jennifer , Lian Xun 
Published: June 2023

Purpose of review
Laparoscopic abdominal cerclage placement has become the favored approach for management of refractory cervical insufficiency. There are special considerations with respect to surgical method, management of pregnancy loss, and delivery following placement. This review addresses current literature on transabdominal cerclage with a focus on up-to-date minimally invasive techniques.

Recent findings
Recent literature on abdominal cerclage has compared laparoscopic and open approaches, evaluated the effect of preconception placement on fertility, and explored the upper gestational limit for dilation and evacuation with an abdominal cerclage in situ.

Summary
The objective of this article is to help minimally invasive surgeons identify candidates for transabdominal cerclage placement, understand surgical risks, succeed in their laparoscopic approach, and appropriately manage patients postoperatively.
Fluorescence Lifetime Imaging Ophthalmoscopy (FLIO) in Macular Telangiectasia Type 2 (MacTel) Patients with and without Diabetes
Authors: Sauer Lydia , Vitale Alexandra S. , Jacoby Rachael S. , Hart Barbara , Bernstein Paul S. 
Published: June 2023

ABSTRACT

Purpose:
Macular telangiectasia type 2 (MacTel) is a vision-altering retinal disease with a high prevalence of diabetes. Differences between MacTel patients with and without diabetes were investigated using fluorescence lifetime imaging ophthalmoscopy (FLIO).

Methods:
86 patients with MacTel (59±12 years) were included. 40 patients (46%) did not have diabetes, 16 patients (19%) were pre-diabetic, and 30 patients (35%) were diabetic. Of these, 7 had diabetic retinopathy (DR). 18 diabetic patients without MacTel and 42 age-matched healthy controls were included. FLIO lifetimes (FLTs) were obtained in short (SSC, 498-560nm) and long (LSC, 560-720nm) spectral channels from different areas of interest using a Heidelberg Engineering FLIO.

Results:
FLTs did not show significant differences when comparing diabetic to nondiabetic MacTel eyes (MacTel-zone, SSC, diabetic: 243±65 ps, nondiabetic: 232±51 ps, p=1.0; LSC, diabetic: 327±66ps, nondiabetic: 309±54ps, p=0.582). Longitudinal changes were similarly unrelated to diabetes status. A non-significant trend of increased FLT-progression with higher BMI was found. FLTs in diabetic patients without MacTel were significantly shorter within the MacTel zone and longer in the periphery compared to diabetic MacTel patients.

Conclusions:
Although MacTel has a high prevalence of diabetes, FLTs from the MacTel-zone are unrelated to diabetes. FLIO retains diagnostic abilities in patients with MacTel even in the presence of pre-diabetes, diabetes, and advanced DR. The lack of diabetic FLT changes in the periphery of diabetic MacTel patients is an interesting finding that needs further investigation.
Injectable Fluocinolone Implant for the Management of Chronic Postsurgical Cystoid Macular Edema in Vitrectomized Eyes
Authors: Patel Kishan G. , Flores Jessica , Abbey Ashkan M. 
Published: June 2023

Abstract

Purpose:
Long-acting injectable steroids are changing the treatment paradigm for patients with chronic intraocular inflammation and cystoid macular edema (CME). We report the use of the fluocinolone implant (FAI) 0.18 mg in patients with chronic postsurgical CME following pars plana vitrectomy (PPV).

Methods:
This is a retrospective case series of 24 vitrectomized eyes which received FAI for the management postsurgical CME. Clinical outcomes and requirement for rescue therapy were studied.

Results:
Median length of follow-up was 19.3 months (range 8.3-23.2 months). There was an improvement in median central subfield thickness from 412 μm (range 167-806 μm) to 311 μm (range 157-686 μm) following FAI (p < 0.001). The injection burden decreased significantly following study treatment (p < 0.001); however, there was no significant change in visual acuity (p = 0.334). Eighteen eyes had control of CME that did not require additional intravitreal therapy. Four eyes had initially controlled but recurrent CME requiring intravitreal steroid therapy at median of 7.8 months (range 7.6-15.4 months). One eye never attained sufficient inflammatory control despite rescue therapy.

Conclusion:
FAI can be an effective treatment in vitrectomized patients with chronic postsurgical CME and can help decrease the overall injection burden.
Validation of the PCL-5, PHQ-9, and GAD-7 in a Sample of Veterans
Authors: Ahmadi Aazi , Ponder Warren N. , Carbajal Jose , Schuman Donna L. , Whitworth James , Yockey R. Andrew , Galusha Jeanine M. 
Published: June 2023

Objective
Veterans can present at nongovernment (Department of Defense, Department of Veterans Affairs) mental health agencies with complex symptom constellations that frequently include posttraumatic stress disorder, depression, and generalized anxiety. To date, no veteran study has validated these measures on a treatment-seeking sample of veterans outside the DoD and VA.

Methods
We used a treatment-seeking sample of veterans (N = 493) to validate measures that assess these constructs (PTSD Checklist 5, Patient Health Questionnaire-9, and Generalized Anxiety Disorder-7).

Results
The seven-factor posttraumatic stress disorder hybrid configuration was the best fit. The best fitting model of the depression measure was a two-factor structure, cognitive-affective, and somatic depression. The measure of generalized anxiety was a unidimensional model.

Limitations
Follow-up studies should validate these measures on nontreatment-seeking discharged veterans.

Conclusions
We interpret these findings within the veteran scholarship and explore clinical implications for providers.
The Dual Labor Market and Workers’ Health Inequality in South Korea
Authors: Choi Sookja , Jung Youn 
Published: June 2023

Objective
We investigated how worker health inequality is potentially linked to the dual labor market in South Korea.

Methods
Using the data from the fifth Korean Working Conditions Survey, we analyzed the data from 21,088 paid workers. We used logistic regression analyses to assess whether employment type or company size had a significant effect on workers’ physical and mental health and work-related injuries.

Results
Workers’ health status was significantly associated with employment type and company size. Nonstandard workers had higher rates of musculoskeletal diseases or injuries, and their self-rated health and psychological well-being were lower than standard workers. Company size showed a significant correlation only for work-related injuries.

Conclusions
The structure of inequality in Korea’s labor market according to employment type and company size seems to be affecting the health and safety of workers.
Genomics of aging: Reactive oxidation and inefficient mitochondria
Authors: Wysocki Kenneth , Heuer Beth 
Published: June 2023

ABSTRACT
Many things are associated with decreased health and lifespan, including cancer, diabetes, atherosclerosis, high blood pressure, and chronic inflammatory conditions. Clinicians may not be familiar with the role that mitochondrial mutations and associated mitochondrial dysfunction play in a shortened lifespan. This article, the fifth in the JAANP Genomics of Aging series, describes the role that mitochondrial dysfunction plays in the development of age-related diseases such as Alzheimer disease, Parkinson disease, cancer, heart disease, and stroke.
Disorders of Gut-brain Interaction on the US-Mexico Border
Authors: Bashashati Mohammad , Schmulson Max J. , Sarosiek Irene , Robles Alejandro , Casner Nancy , Espino Karina , Elhanafi Sherif E. , Zuckerman Marc J. 
Published: June 2023

Background:
Disorders of gut-brain interaction (DGBI) cause a substantial health burden. Herein we studied the prevalence and characteristics of DGBI and symptoms of bloating/distension in El Paso, Texas on the US-Mexico border, providing a unique opportunity to study the effects of acculturation.

Methods:
Subjects from community centers completed the Rome IV questionnaire for DGBI, short acculturation scale for Hispanics questionnaire, and bloating/distention Pictograms. Data were presented as prevalence (95% CI) and compared using χ2.

Results:
Of 216 participants, 197 (127 Hispanics, 90 with English acculturation) were included and 177 completed the Pictograms. Fifty-one [25.9% (20 to 32.6)] subjects fulfilled the criteria for at least one DGBI. Globus and functional dyspepsia were the most common upper DGBI, each in [3.0% (1.1 to 6.5)]. Unspecified functional bowel disorders [8.6% (5.1 to 13.5)], followed by functional abdominal bloating/distention [8.1% (4.7 to 12.9], and irritable bowel syndrome [6.1% (3.2 to 10.4] were the most common functional bowel disorder. Ninety-one (51.4%) reported bloating and/or distension with Pictograms; more frequently in those with DGBI (80.9% vs 40.8%, P < 0.001). Bloating and/or distension were reported by Pictograms in 30% of those not reporting it in the Rome IV Questionnaire. There were no differences based on acculturation or in Hispanics versus non-Hispanics.

Conclusions:
On the US-Mexico border, we found a lower prevalence of DGBI than in the US or Mexico. Functional abdominal bloating/distention was more prevalent on the US-Mexico border than in either country. Bloating/distension was more commonly reported with Pictograms than with verbal descriptors. There were no differences between Hispanics and non-Hispanics, suggesting shared environmental/acquired including dietary factors as the underlying mechanisms.
Pneumonia caused by Schizophyllum commune in a patient with diabetes: A case report and comprehensive literature review
Authors: Chen Xing , Sun Jian , Chen YeFeng , Wang Jie , Liu ShuYing 
Published: June 2023

Rationale:

Schizophyllum commune (S. commune) is a basidiomycete bracket fungus that rarely causes invasive fungal infections. It is often misdiagnosed as other invasive fungal disease because of its atypical clinical features. Here we report a case of pneumonia due to S commune and review the relevant literature.

Patient concerns and diagnoses:
A 55-year-old male with a history of diabetes and poor glycemic control presented with cough and sputum for half a month. Laboratory examination showed elevated peripheral blood eosinophils, bronchoalveolar lavage fluid eosinophils and increased serum total immunoglobulin E. Chest computed tomography revealed a gloved finger sign and consolidation in the middle lobe of the right lung and the upper lobe of the left lung. Bronchoscopy revealed thick white mucous plugs in the left lingular bronchus, which could be removed partially by suctioning. The culture of bronchoalveolar lavage fluid and bronchoscopy brush specimens grew cottony white mold in sabouraud dextrose agar. Pneumonia caused by S. commune was diagnosed based on clinical features and microbial methods.

Interventions and outcomes:
Voriconazole combined with inhaled budesonide and formoterol (inhaled corticosteroids + long-acting β-2 receptor agonist) were given, and his symptoms improved. The count of peripheral blood eosinophils and serum total immunoglobulin E decreased after 1 month. Repeated chest computed tomography showed remarkable improvement over the previous lesions.

Lessons:
Although rarely reported, infections in the lungs caused by S commune should be reminded especially in patients with immunocompromised. This case illustrates the risk factors, clinical symptoms and imaging features of the pneumonia caused by S. commune. It also further highlights the diagnosis and treatment of this disease through reviewing relevant literature.
Validity and reliability of the single camera marker less motion capture system using RGB-D sensor to measure shoulder range-of-motion: A protocol for systematic review and meta-analysis
Authors: Lee Unhyung , Lee Suji , Kim Sung-A , Lee Jae-Dong , Lee Seunghoon 
Published: June 2023

Background:
The range-of motion (ROM) is an essential component of joint mobility. Shoulder ROM measurement has been problematic due to its complexity. A marker less motion capture system can be a potential alternative for upper limb assessment. Currently, there is no systematic review to evaluate the validity of a marker less motion capture system for assessing shoulder ROM. This study aims to describe methods to evaluate the reliability and validity of a single camera marker less motion capture system that uses an RGB-depth sensor to measure shoulder ROM.

Methods:
Studies that measured shoulder ROM with a single camera marker less motion capture system using the RGB-depth sensor and assessed the intra- and/or inter-rater reliability, and/or validity of the device will be included. The search of electronic databases, such as MEDLINE, EMBASE, Cochran library, Cumulative Index to Nursing, and Allied Health Literature via EBSCO, IEEE Xplore, China National Knowledge Infrastructure, KoreaMed, Korean studies Information Service System, and Research Information Sharing Services will be performed for all relevant articles from inception to December 2022. Two authors will independently perform quality assessments using the Consensus-based Standards for the selection of health Measurement Instruments checklist for reliability, measurement error of outcome measurement instrument, and criterion validity. The primary outcomes will be the intra- and inter-rater reliability and validity of the markerless motion capture system measuring shoulder flexion, extension, abduction, adduction, internal rotation, or external rotation. A subgroup analysis would be performed if there are sufficient data to pool to identify an influencing factor in the measurement of ROM using a marker less motion capture system.

Results and Conclusion:
These findings will present tools to utilize and evaluate single camera motion capture systems for the medical use for clinicians and healthcare experts and can aid in further clinical research using such a system for different movements and other joints.
Comparison of Short-Tau Inversion Recovery With Short-Tau Inversion Recovery–Slice Encoding for Metal Artifact Correction for Spine Imaging at 1.5 T in the Setting of Metallic Implants
Authors: Yang Jie-Yu , Hsieh Tsyh-Jyi , Chen Clement Kuen-Huang , Lin Chien-Hung , Chou Yi-Chen 
Published: June 2023

Objective
To compare the image quality of short-tau inversion recovery (STIR) and the STIR-slice encoding for metal artifact correction (SEMAC) sequence for postsurgery spine magnetic resonance imaging (MRI).

Methods
Twenty-nine patients with metallic spinal implants who underwent spinal 1.5 T MRI with STIR and STIR-SEMAC sequences between July 2016 and November 2020 were retrospectively enrolled. Qualitative assessments were performed using 5-point scales; higher scores indicated better image quality. For screw metal artifact analysis, scores were obtained for artifacts on vertebral bodies and neural foramina, screw artifact widths, and bone marrow signal intensities. For patient-based analysis, scores were obtained for imaging quality and fat suppression quality, signal intensity, and cerebrospinal fluid noise. A paired t test was performed for statistical analyses.

Results
We analyzed 163 screws in 29 patients. In the screw metal artifact analysis, the vertebral body and neural foramen scores were significantly higher for the STIR-SEMAC images than for the STIR (all P < 0.001). The artifact width in the STIR-SEMAC images (9.8 ± 3.4 mm) was significantly smaller than that in the STIR images (16.0 ± 4.7 mm, P < 0.001). In patient-based analysis, the fat suppression and imaging quality scores were significantly higher for the STIR-SEMAC images than for the STIR images (all P < 0.001). The cerebrospinal fluid signal intensity, noise, and signal-to-noise ratios were significantly higher for the STIR images (all P < 0.005).

Conclusions
Short-tau inversion recovery–SEMAC sequences provide good metallic artifact reduction and fat suppression for postsurgery spine 1.5 T MRI.
EFFECTS OF TRANEXAMIC ACID ON NEUROPATHOLOGY, ELECTROENCEPHALOGRAPHY, AND CEREBRAL FIBRIN DEPOSITION IN A RAT MODEL OF POLYTRAUMA WITH CONCOMITANT PENETRATING TRAUMATIC BRAIN INJURY
Authors: Bailey Zachary S. , Yang Xiaofang , Cardiff Katherine , Wang Ping , Houchins Melonie , Lu Xi-Chun , Cao Ying , Gilsdorf Janice , Scultetus Anke , Shear Deborah 
Published: June 2023

ABSTRACT
Several studies have demonstrated the clinical utility of tranexamic acid (TXA) for use in trauma patients presenting with significant hemorrhage. Tranexamic acid is an antifibrinolytic that inhibits plasminogen activation, and plasmin activity has been shown to mitigate blood loss and reduce all-cause mortality in the absence of adverse vascular occlusive events. Recent clinical developments indicate TXA is safe to use in patients with concomitant traumatic brain injury (TBI); however, the prehospital effects are not well understood. Importantly, TXA has been associated with seizure activity. Therefore, this study sought to evaluate the effects of early administration of TXA on neurological recovery and electroencephalogram (EEG) abnormalities following penetrating TBI with concomitant hypoxemia and hemorrhagic shock. We hypothesized that early administration of TXA will provide hemodynamic stabilization and reduce intracerebral hemorrhage, which will result in improved neurological function. To test this hypothesis, Sprague-Dawley rats received a unilateral, frontal penetrating ballistic-like brain injury by inserting a probe into the frontal cortex of the anesthetized rat. Five minutes following brain injury, animals underwent 30 min of respiratory distress and 30 min of hemorrhage. Upon completion of the hemorrhage phase, animals received the initial dose of drug intravenously over 10 min after which the prehospital phase was initiated. During the prehospital phase, animals received autologous shed whole blood as needed to maintain a MAP of 65 mm Hg. After 90 min, “in-hospital” resuscitation was performed by administering the remaining shed whole blood providing 100% oxygen for 15 min. Upon recovery from surgery, animals were administered their second dose of vehicle or TXA intravenously over 8 h. Tranexamic acid induced an early improvement in neurologic deficit, which was statistically significant compared with vehicle at 24, 48, and 72 h at three doses tested. Analysis of cerebral hemoglobin content and intracerebral lesion progression revealed 100 mg/kg provided the optimal effects for improvement of neuropathology and was continued for determination of adverse treatment effects. We observed no exacerbation of cerebral thrombosis, but TXA treatment caused an increased risk of EEG abnormalities. These results suggest that TXA following polytrauma with concomitant brain injury may provide mild neuroprotective effects by preventing lesion progression, but this may be associated with an increased risk of abnormal EEG patterns. This risk may be associated with TXA inhibition of glycine receptors and may warrant additional considerations during the use of TXA in patients with severe TBI.
Management and Outcomes of Wilms Tumor with Suprarenal Intravascular Extension
Authors: Naik-Mathuria Bindi , Utria Alan F. , Ehrlich Peter F , Aldrink Jennifer H. , Murphy Andrew J. , Lautz Timothy , Dasgupta Roshni , Short Scott S. , Lovvorn Harold N. , Kim Eugene S. , Newman Erica , Lal Dave R. , Rich Barrie S. , Piché Nelson , Kastenberg Zachary J. , Malek Marcus M. , Glick Richard D. , Petroze Robin T. , Polites Stephanie F. , Whitlock Richard , Alore Elizabeth , Sutthatarn Pattamon , Chen Stephanie Y. , Wong-Michalak Shannon , Romao Rodrigo LP , Al-Hadidi Ameer , Rubalcava Nathan S. , Marquart John P. , Gainer Hailey , Johnson Mike , Boehmer Chloe , Rinehardt Hannah , Seemann Natashia M. , Davidson Jacob , Polcz Valerie , Lund Sarah B. , McKay Katlyn G. , Correa Hernan , Rothstein David H. 
Published: June 2023

Objective:
The purpose of this study was to describe management and outcomes from a contemporary cohort of children with Wilms Tumor (WT) complicated by inferior vena caval thrombus.

Summary Background Data:
The largest series of these patients was published almost two decades ago. Since then, neoadjuvant chemotherapy has been commonly used to manage these patients and outcomes have not been reported.

Methods:
Retrospective review from 19 North American centers between 2009-2019. Patient and disease characteristics, management, and outcomes were investigated and analyzed.

Results:
Of 124 patients, 81% had favorable histology (FH), and 52% were stage IV. IVC thrombus level was infrahepatic in 53 (43%), intrahepatic in 32 (26%), suprahepatic in 14 (11%), and cardiac in 24 (19%). Neoadjuvant chemotherapy using a 3-drug regimen was administered in 82% and post-resection radiation in 90%. Thrombus level regression was 45% overall, with suprahepatic level showing the best response (62%). Cardiopulmonary bypass (CPB) was potentially avoided in 67%. Peri-operative complication rate was significantly lower following neoadjuvant chemotherapy ([25%] vs. Upfront surgery [55%]; P=0.005). CPB was not associated with higher complications (CPB [50%] vs. no CPB [27%]; P=0.08). Two-year event-free survival (EFS) was 93% and overall survival (OS) was 96%, higher in FH cases (FH 98% vs. unfavorable histology/anaplastic 82%; P=0.73). Neither incomplete resection nor viable thrombus cells affected EFS or OS.

Conclusions:
Multimodal therapy resulted in excellent outcomes, even with advanced stage disease and cardiac extension. Neoadjuvant chemotherapy decreased the need for CPB to facilitate resection. Complete thrombectomy may not always be necessary.