bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unique duck rearing practice in irrigated rice paddy fields driving recurrent H5N1 avian influenza outbreaks in two districts of Kerala, India
Authors: Chanda Mohammed Mudassar , Shivachandra Sathish Bhadravati , Mishra Adhiraj , Punnoose Previn , Panikkassery Shaji , Potti Sanjay Devarajan , Mohan Vysakh , Prajapati Awadhesh , Yogisharadhya Revanaiah , Hemadri Divakar , Gulati Baldev Raj , Tosh Chakradhar 
Published: January 2025

Abstract
Highly pathogenic avian influenza (HPAI) outbreaks have repeatedly occurred in two districts of Kerala state, India, over the last few years. The outbreaks in the wetland areas coincided with the arrival of migratory birds. At the time, the factors responsible for local transmission in ducks were not known. This study aimed to identify the socio-economic factors responsible for spatial variation in the occurrence of HPAI outbreaks in the two districts using Bayesian network modelling (BNM) and Stochastic Partial Differential Equation (SPDE) model. Further, information was collected on the duck rearing practices in rice paddy fields to identify the risk factors for local – spread of the outbreaks. We found that the SPDE model without covariates explained variation in occurrence of outbreaks. The number of rice paddy fields used by the duck farmers was identified as risk factor. We concluded based on BNM and SPDE that the infected migratory birds were the source of infection for the first few duck farms in the wetland areas and subsequent transmission was driven by shifting of ducks from one rice paddy field to other fields. There is a probability of persistent and recurrent infections in the ducks and possible spill over to humans. Hence, it is important to have surveillance in ducks to prevent recurrent outbreaks in the region.
The healthfulness of major food brands according to Health Canada’s nutrient profile model for proposed restrictions on food marketing to children
Authors: Vergeer Laura , Mulligan Christine , Jeong Hayun , Khan Ayesha , L’Abbé Mary R 
Published: January 2025

Abstract

Objective:
To examine the proportion of products offered by leading food brands in Canada that are ‘unhealthy’ according to Health Canada’s (HC) nutrient profile model for proposed restrictions on food marketing to children (M2K-NPM).

Design:
Nutritional information for products offered by top brands was sourced from the University of Toronto FLIP and Menu-FLIP 2020 databases, respectively. HC’s M2K-NPM, which includes thresholds for Na, total sugars and saturated fat, was applied to products.

Setting:
Canada.

Participants:
Overall, 1385 products from top breakfast cereal (n 15 brands, n 222 products), beverage (n 21 brands, n 769 products) and yogurt (n 10 brands, n 394 products) brands, and 3153 menu items from seventeen chain restaurants in Canada were assessed (n 60 unique brands overall).

Results:
For 42 % of brands (n 21), 100 % of their products exceeded ≥1 nutrient threshold(s), with ≥50 % of the products offered by twenty-three brands (46 %) exceeding two thresholds. Specifically, one or more nutrient thresholds were exceeded by ≥50 % of the products offered by 14/15 breakfast cereal brands, 18/21 beverage brands, all ten yogurt brands and all seventeen restaurant brands. Notably, 100·0 % of the products offered by ten breakfast cereal, six beverage, two yogurt and three restaurant brands exceeded ≥1 threshold(s).

Conclusions:
Most products offered by top food brands in Canada exceeded HC’s M2K-NPM thresholds. Nonetheless, these brands could still be marketed under the proposed regulations, which exclude brand marketing (i.e. promotions without an identifiable product) despite its contribution to marketing power. These findings reinforce the need for Canada and other countries to include brand marketing in M2K policies.
Receipt of humanitarian cash transfers, household food insecurity and the subjective wellbeing of Syrian refugee youth in Jordan
Authors: Sieverding Maia , Jamaluddine Zeina 
Published: January 2025

Abstract

Objective:
Humanitarian aid, including food aid, has increasingly shifted towards the provision of cash assistance over in-kind benefits. This paper examines whether food security mediates the relationship between receipt of humanitarian cash transfers and subjective wellbeing among Syrian refugee youth in Jordan.

Design:
Secondary analysis of the 2020–21 Survey of Young People in Jordan, which is nationally representative of Syrian youth aged 16–30. We employ stepwise model building and structural equation models.

Setting:
Jordan.

Participants:
Syrian refugee youth aged 16–30 (n 1572).

Results:
While 92 % of Syrian households with youth received cash transfers from a UN agency, 78 % of households were food insecure using the Food Insecurity Experience Scale. Fifty-one percent of youth suffered from poor wellbeing using the WHO-5 subjective wellbeing scale. Household food insecurity was associated with poorer youth wellbeing. Receiving larger cash transfer amounts was associated with better wellbeing among Syrian youth in unadjusted models. The relationship between receipt of cash transfers and youth wellbeing was not mediated by food security.

Conclusion:
We do not find support for the hypothesis that food security is a mediator of the association between cash transfers and subjective wellbeing for this population.
Labor Union Membership and Women’s Political Ambition: Evidence from the United States
Authors: Macdonald David 
Published: January 2025

Abstract
Women have long been underrepresented in American politics. This is evidenced by women being less likely to run for and hold elected office. Existing scholarship largely focuses on explaining why women are less politically ambitious than their male counterparts but pays less attention to why some women do run for office. To this end, I focus on the potential role of labor union membership. I argue that labor unions can foster political ambition and increase ordinary people’s likelihood of running for office. I test this among women in the American mass public, primarily with survey data from the 2010–22 Cooperative Election Study (CES). Overall, I find that labor union membership is significantly associated with women’s likelihood of running for office. I also find that this robust relationship is unlikely to be driven by self-selection or omitted variable biases. Overall, these findings help us to better understand the sources of political ambition, illustrate a viable potential pathway to boost women’s likelihood of seeking elected office, and underscore the political consequences of organized labor.
Just informal patient payments are not enough, ‘personal connections’ and knowledge of the ‘rules’ are also required: a logistic regression analysis of informal practices in health care in Ukraine
Authors: Levenets Olena , Stepurko Tetiana , Polese Abel , Pavlova Milena , Groot Wim 
Published: January 2025

Abstract
In Ukraine, patients and their family members face numerous barriers to health care services. In response, they use coping strategies, that are manifold and complex activities aimed at overcoming these barriers, the financial burden of the treatment, and the poor quality of health care services. These activities include formal and informal practices. Based on representative survey data from 2015 (N = 2,022), we identify patterns in the use of coping strategies, specific coping strategies used to secure good quality consultation and treatment, and analyse opinions and actions towards coping practices. We further analyse the factors associated with the last experience of coping and look at patterns of connection building. We find that the chances of using both money and connection as a coping strategy are higher for people with incomplete higher and highest levels of education. The size of this effect increases with the level of education. Older people, people with better health, and people with a higher opinion of the state use informal practices less, while women are more active in developing connections. The closer the relationship is with a medical doctor, the higher is the chance that such connection will be used in case of health service consumption.
Reimbursement prices of new, innovative medicines in Germany: a comparison of negotiation and cost-effectiveness analysis
Authors: Gandjour Afschin 
Published: January 2025

Abstract
This study aimed to compare reimbursement prices for new, innovative non-orphan drugs in Germany based on price negotiation and cost-effectiveness analysis, using the efficiency frontier (EF) approach and cost-utility analysis (CUA). For the EF, the next effective intervention and no intervention were used as comparators. Three pairwise comparisons were conducted: negotiation vs EF, CUA vs EF and negotiation vs CUA. For the comparison between negotiation and EF, relative risk reductions for a given added health benefit were assigned, and resulting price premiums were determined using an empirical estimate from the literature and a conceptual model. The difference between CUA vs EF was determined based on an aggregation rule and thresholds for CUA based on the average and marginal cost-effectiveness of the health care system. The difference between negotiation and CUA was determined through an indirect comparison. Price premiums based on negotiation are approximately 10–40 per cent higher than those based on EF using no intervention as a comparator. Furthermore, price premiums based on CUA (threshold at system-average cost-effectiveness) are approximately 25–50 per cent higher than those based on EF using no intervention as a comparator. The indirect comparison predicts that price premiums based on CUA (threshold at system-average cost-effectiveness) are approximately 10–15 per cent higher than those based on negotiation. For a threshold set at system-marginal cost-effectiveness, price premiums based on CUA are more than threefold higher than those based on negotiation. In the German health care system, CUA with a threshold set at system-average or system-marginal cost-effectiveness is predicted to yield higher reimbursement prices than price negotiations or the EF approach based on no intervention as a comparator.
Ten Years of Earth and Space Science: Introduction to the Special Collection
Authors: Caprarelli Graziella , Baratoux David , Bulusu Subrahmanyam , Cervato Cinzia , Diviacco Paolo , Donea Alina , Fletcher Steven J. , Glaves Helen M. , Jones Cathleen E. , Lu Gaopeng , Maute Astrid , Mills Franklin P. , Pryor Sara C. , Tiampo Kristy , Xie Zunyi 
Published: January 2025

AbstractThe journal Earth and Space Science (ESS) was founded in 2014 to offer the scientific community a new platform for the dissemination of key new data, observations, methods, instruments, and models, presented within the context of their application. Thus, the aim of the journal was (and is) to highlight the complexity and importance of experimental design, methodology, data acquisition and processing, intertwined with data interpretation. Such approach is consistent with the mission of most AGU journals, but the distinctive element for ESS is its focus on the concept of the useful impact of publication, progressively replacing that on conventional publication metrics. In this context, the journal has been, since its inception, the preferred home for studies stemming from both global and local geoscience research. This special collection contains 16 papers published in ESS, selected by the Editorial Board to highlight the aims, scope and path of evolution and growth of the journal since it inaugural issue, in 2014.
Spectral Structures of Jovian Broadband Kilometric Radiation Revealed by Cassini and Juno
Authors: Fischer G. , Taubenschuss U. , Píša D. , Imai M. , Kurth W. S. 
Published: January 2025

AbstractCassini flew past Jupiter in 2000/2001, and Juno has been orbiting the gas giant since mid‐2016. Here we focus on the spectral properties of Jovian broadband kilometric radiation (bKOM), and we classified them according to their slope in the time–frequency spectrum and distinguish four categories with negative, positive, mixed, or no slope in frequency. These bKOM structures had mostly negative slopes during the inbound portion of the Cassini Jupiter flyby, whereas they were mostly positive for the outbound. The reason for this could be higher intensities of bKOM emissions from midnight to dawn local times. We interpret the semi‐circles of the Jovian radio emission nicknamed “bullseyes” as negatively sloped bKOM connected with positively sloped bKOM, and we detected 40 bullseyes in Juno Waves data until the end of 2017. Cassini and Juno show similar distributions of bKOM with respect to the Jovian Central Meridian Longitude like the Voyagers and Ulysses. This means that bKOM has not changed over several decades and “rotates” with the system III period. Several features of the bKOM structures suggest emission cones with thick mantles and moderate beaming angles around . We found an enhancement of the occurrence probability of southern bKOM for certain phases of Ganymede and Callisto.
The Hawaii Dust Regime: Patterns and Variability in Aerosol Mineral Dust From MERRA‐2 at Station ALOHA and the Hawaii Aerosol Time‐Series
Authors: Ohnemus Daniel C. , Kollman Charlotte , Marsay Christopher M. , Ricci Mariah , Buck Clifton S. 
Published: January 2025

AbstractThe transport and delivery of low‐abundance, bioactive trace elements to the surface ocean by aerosol mineral dust is a major planetary control over marine primary production and hence the global carbon cycle. Variations in the concentration of atmospheric dust have established links to global climate over geologic timescales and to regional biogeographic shifts over seasonal timescales. Constraining atmospheric dust variability is thus of high value to understanding oceanographic systems, especially vast, constitutively low‐nutrient subtropical gyre ecosystems and high‐nutrient/low‐chlorophyll ecosystems where availability of the trace element iron is a dominant ecological control. Here we leverage the MERRA‐2 reanalysis product to examine over four decades of surface‐level atmospheric mineral dust concentrations in a domain of the subtropical North Pacific centered at Ocean Station ALOHA. This study region has been sampled regularly since the mid‐1980s and was the site of the Hawaii Aerosol Time‐Series (HATS) project in 2022–2023. Two unequal semi‐annual periods of elevated dust evident in the long‐term results are described and constrained. We look for evidence of shifts in total and seasonal atmospheric dust abundances or in the timing of the onset of the dominant spring/summer dusty period, finding year‐to‐year variations but little evidence for long‐term trends. We observe significant but complex relationships between the Pacific Decadal Oscillation (PDO) index and both dust and precipitation. The 2022 calendar year was among the dustiest years for the study domain in the preceding two decades and, by contrast, 2023 exhibited a significant early spring lull in dust.
Study of an Extremely Strong Quasi‐20‐Sol Wave During a Global Dust Storm in Mars Year 34
Authors: Xiao Qiao , Ma Zheng , Gong Yun , Zhang Shaodong , Huang Chunming 
Published: January 2025

AbstractBased on the temperature and dust opacity data from the Mars Reconnaissance Orbiter/Mars Climate Sounder and the OpenMars reanalysis, we report an extremely strong quasi‐20‐sol wave (Q20SW) during the global dust storm (GDS) in Mars Year (MY) 34. After the onset of the GDS in MY34, the amplitude of the Q20SW reaches approximately 12 K in temperature, which is the strongest from MY29 to MY35. By analyzing the Eliassen‐Palm fluxes of the Q20SW and their divergences, we conclude that the Q20SW is enhanced due to the unseasonal temperature increase caused by the GDS. Moreover, we find a strong eastward propagating oscillation with a period of 12–16 sols and a wavenumber of 1 exists in the dust opacity after the commencement of the GDS. This indicates that the strong Q20SW could also modulate the dust variation in the middle latitudes during the GDS.
Meteorological Conditions Influence the Migration of a Marine Dune Field in the Southern North Sea
Authors: Durand Noémie , Tassi Pablo , Blanpain Olivier , Lefebvre Alice 
Published: January 2025

AbstractA field of marine dunes has been studied in the Southern Bight of the North Sea. These large dunes, 1–5 m in height and several hundred meters in length, are highly mobile: migration rates of up to 30 m/year have been observed in places. The area is dominated by tides and is characterized by strong currents. Winds are predominantly from the southwest and, to a lesser extent, from the north. A large‐scale 3D numerical model was used to simulate the migration of this dune field over time. It is based on the process‐based opentelemac system. The model has been calibrated and validated against in situ bathymetric data and is therefore suited to our objective: to explore the contribution of weather (wind and atmospheric pressure) to the propagation of large marine dunes, in relation to that of tidal currents. To do this, a 4‐month period was simulated, with and without meteorological effects being taken into account in the numerical model. The results highlight the fundamental role of wind conditions in an accurate representation of seabed changes over time. They also show how meteorological events that are different from the prevailing conditions influence the short‐term evolution of the dune field.
Sociobiology meets oncology: unraveling altruistic cooperation in cancer cells and its implications
Authors: bin Masroni Muhammad Sufyan , Koay Evelyn Siew-Chuan , Lee Victor Kwan Min , Ng Siok Bian , Tan Soo Yong , Tan Karen Meiling , Archetti Marco , Leong Sai Mun 
Published: January 2025

Abstract
Altruism, an act of benefiting others at a cost to the self, challenges our understanding of evolution. This Perspective delves into the importance of altruism in cancer cells and its implications for therapy. Against the backdrop of existing knowledge on various social organisms found in nature, we explore the mechanisms underlying the manifestation of altruism within breast tumors, revealing a complex interplay of seemingly counteracting cancer signaling pathways and processes that orchestrate the delicate balance between cost and benefit underlying altruistic cooperation. We also discuss how evolutionary game theory, coupled with contemporary molecular tools, may shed light on understudied mechanisms governing the dynamics of altruistic cooperation in cancer cells. Finally, we discuss how molecular insights gleaned from these mechanistic dissections may fuel advancements in our comprehension of altruism among cancer cells, with implications across multiple disciplines, offering innovative prospects for therapeutic strategies, molecular discoveries, and evolutionary investigations.
A systematic assessment of the stability of SLA® vs. SLActive® implant surfaces over 12 weeks
Authors: Patel Rohit , Patel Serena , Girgis Wail , Ahmed Waqar , Barrak Fadi 
Published: January 2025

Abstract
Objective
This study aims to assess the impact of two implant surfaces, SLA and SLActive, on implant stability, measured by ISQ levels over a 12-week period.

Methods
A comprehensive search of MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, and Dentistry and Oral Sciences databases for randomized controlled trials (RCTs) up to February 2023 was conducted. The inclusion criteria were studies involving adult patients treated with SLA and SLActive implants, with assessment of implant stability through ISQ levels up to 12 weeks post-placement.

Results
From the initial 180 potentially eligible publications identified, six RCTs were included in our analysis, comprising 326 implants (50.6% SLA and 49.4% SLActive). Three studies were classified as low risk, while three had an unclear risk of bias. Overall, SLActive implants demonstrated comparable stability levels, as measured by ISQ, to SLA implants within the 12-week interval for implants placed in the maxillary or mandibular region. However, findings from the RCTs suggest that the SLActive surface led to an earlier transition point, a faster return to stability levels, and higher ISQ values at the end of 12 weeks compared to the SLA surface for implants placed in the palatal region.

Conclusion
SLActive surfaces exhibited stability levels similar to SLA surfaces for maxillary and mandibular implants. Notably, for palatal implants, SLActive resulted in a quicker transition point and higher stability levels at the 12-week mark. Due to the limited number of trials and potential study heterogeneity, further research is needed to validate these findings.
NPC1 controls TGFBR1 stability in a cholesterol transport-independent manner and promotes hepatocellular carcinoma progression
Authors: Li Shuangyan , Yan Lishan , Li Chaoying , Lou Lijuan , Cui Fengjiao , Yang Xiao , He Fuchu , Jiang Ying 
Published: January 2025

AbstractNiemann-Pick disease type C protein 1 (NPC1), classically associated with cholesterol transport and viral entry, has an emerging role in cancer biology. Here, we demonstrate that knockout of Npc1 in hepatocytes attenuates hepatocellular carcinoma (HCC) progression in both DEN (diethylnitrosamine)-CCl4 induced and MYC-driven HCC mouse models. Mechanistically, NPC1 significantly promotes HCC progression by modulating the TGF-β pathway, independent of its traditional role in cholesterol transport. We identify that the 692-854 amino acid region of NPC1’s transmembrane domain is critical for its interaction with TGF-β receptor type-1 (TGFBR1). This interaction prevents the binding of SMAD7 and SMAD ubiquitylation regulatory factors (SMURFs) to TGFBR1, reducing TGFBR1 ubiquitylation and degradation, thus enhancing its stability. Notably, the NPC1 (P691S) mutant, which is defective in cholesterol transport, still binds TGFBR1, underscoring a cholesterol-independent mechanism. These findings highlight a cholesterol transport-independent mechanism by which NPC1 contributes to the stability of TGFBR1 in HCC and suggest potential therapeutic strategies targeting NPC1 for HCC treatment.
FUT10 and FUT11 are protein O-fucosyltransferases that modify protein EMI domains
Authors: Hao Huilin , Yuan Youxi , Ito Atsuko , Eberand Benjamin M. , Tjondro Harry , Cielesh Michelle , Norris Nicholas , Moreno Cesar L. , Maxwell Joshua W. C. , Neely G. Gregory , Payne Richard J. , Kebede Melkam A. , Urbauer Ramona J. Bieber , Passam Freda H. , Larance Mark , Haltiwanger Robert S. 
Published: January 2025

Abstract

O-Fucosylation plays crucial roles in various essential biological events. Alongside the well-established O-fucosylation of epidermal growth factor-like repeats by protein O-fucosyltransferase 1 (POFUT1) and thrombospondin type 1 repeats by POFUT2, we recently identified a type of O-fucosylation on the elastin microfibril interface (EMI) domain of Multimerin-1 (MMRN1). Here, using AlphaFold2 screens, co-immunoprecipitation, enzymatic assays combined with mass spectrometric analysis and CRISPR–Cas9 knockouts, we demonstrate that FUT10 and FUT11, originally annotated in UniProt as α1,3-fucosyltransferases, are actually POFUTs responsible for modifying EMI domains; thus, we renamed them as POFUT3 and POFUT4, respectively. Like POFUT1/2, POFUT3/4 function in the endoplasmic reticulum, require folded domain structures for modification and participate in a non-canonical endoplasmic reticulum quality control pathway for EMI domain-containing protein secretion. This finding expands the O-fucosylation repertoire and provides an entry point for further exploration in this emerging field of O-fucosylation.