bluuebunny/crossref_metadata_2025_split huggingface dataset:
Venetoclax with decitabine or azacitidine in the first‐line treatment of acute myeloid leukemia
Authors: Bouligny Ian M. , Murray Graeme , Doyel Michael , Patel Tilak , Boron Josh , Tran Valerie , Gor Juhi , Hang Yiwei , Alnimer Yanal , Zacholski Kyle , Venn Chad , Wages Nolan A. , Grant Steven , Maher Keri R. 
Published: February 2023

AbstractTreatment paradigms for acute myeloid leukemia (AML) have evolved at a rapid pace in recent years. The combination of venetoclax with a hypomethylating agent prolonged survival in clinical trials when compared to hypomethylating agent monotherapy. However, little is known about the performance of venetoclax‐based regimens outside of clinical trials, given conflicting safety and efficacy data. Even less is known about the impact of the hypomethylating agent backbone. In this study, we demonstrate that decitabine‐venetoclax is associated with a significantly higher rate of grade three or higher thrombocytopenia, but lower rates of lymphocytopenia compared to azacitidine‐venetoclax. There was no difference in response or survival across ELN 2017 cytogenetic risk categories in the overall cohort. Significantly more patients succumb to relapsed or refractory disease than death from any other cause. We demonstrated that a Charlson comorbidity index score threshold of seven identifies exceptionally high‐risk patients, providing evidence for clinical use to reduce the risk of early treatment‐related mortality. Lastly, we provide evidence that measurable residual disease negativity and an IDH mutation predict a significant survival benefit outside clinical trials. Taken together, these data illuminate the real‐world performance of venetoclax and decitabine or azacitidine in the treatment of AML.
Knockdown of biglycan reveals an important role in maintenance of structural and mechanical properties during tendon aging
Authors: Darrieutort‐Laffite Christelle , Beach Zakary M. , Weiss Stephanie N. , Eekhoff Jeremy D. , Soslowsky Louis J. 
Published: February 2023

AbstractBiglycan, a small leucine‐rich proteoglycan (SLRP), is involved in collagen fibrillogenesis and also acts as a signaling molecule. Although decorin has been considered as the primary SLRP in developing and maintaining tendon structure and mechanics, more recent work using inducible knockdown models suggests that biglycan is involved in tendon homeostasis. The purpose of the study was to determine the role of biglycan in tendon homeostasis to maintain mechanical and structural integrity in aged mice. Aged (485 days old) female Bgn+/+ control (wild type [WT], n = 16) and 16 bitransgenic conditional Bgnflox/flox mice (I‐Bgn−/−, n = 16) with a tamoxifen‐inducible Cre (driven by ROSA) were utilized. After biglycan knockdown, the transgenic model demonstrated effective knockdown of the target gene without any compensation from other SLRPs or type I collagen. Patellar tendon cellularity was not modified after biglycan knockdown. However, biglycan knockdown had an impact on collagen fibrillogenesis with a higher percentage of small diameter fibrils (25–45 nm) and a lower percentage of medium size fibrils (150–165 nm) in I‐Bgn−/− tendons. Biglycan knockdown also induced a reduction in the midsubstance modulus and maximum stress compared to WT. Stress relaxation was reduced at 4% strain in I‐Bgn−/− tendons but no changes were observed in dynamic modulus and tan delta. As in mature tendons (120 days old), this study showed significant effects of biglycan knockdown on mechanical and structural properties of aged tendons only 30 days after knockdown. These data suggest that biglycan has a major role in maintaining homeostasis in aged tendon.
Enhancing maize grain yield under salt‐affected field conditions using salt‐resistant maize hybrids and higher planting density
Authors: Saqib Muhammad , Schubert Sven 
Published: February 2023

AbstractBackgroundIn arid and semiarid countries, grain yield of maize is increasingly impaired by soil salinity. Beside soil amelioration, the development of salt‐resistant cultivars is a possibility to enhance crop yield on salt‐affected soils.AimsThis study aimed at testing yield performance in the field of salt‐resistant maize hybrids on a salt‐affected soil. In addition, planting density was optimized under the saline conditions.MethodsFour salt‐resistant maize hybrids (Zea mays L. SR‐05, SR‐12, SR‐15, and SR‐16) were grown under control (EC = 2.0–2.5 dS m−1) and saline (EC = 10.0–12.0 dS m−1) field conditions and compared to the salt‐sensitive maize cv. Pioneer‐3906. Planting density (5, 8, or 11 plants m−2) was optimized for saline soil conditions for SR‐12 and the local hybrid EV‐78.ResultsYield of Pioneer‐3906 was significantly reduced under salinity because of inhibited kernel setting, whereas the SR hybrids showed no decrease in grain yield. Based on grain yield, the optimum planting density was 8 plants m−2 with no further increase with 11 plants m−2. In contrast to SR‐12, for cv. EV‐78 no increase of harvest index with 8 relative to 5 plants m−2 was observed.ConclusionsVegetative growth of Pioneer‐3906 and the SR hybrids was decreased due to Phase‐I effects but neither due to water deficiency nor ion toxicity. The experiment corroborated the salt resistance of the SR hybrids under field conditions. Under saline conditions, optimum planting density of salt‐resistant cultivars may be higher than under nonsaline conditions when sufficient water supply by artificial irrigation is guaranteed.
Sample and library preparation approaches for the analysis of the virome of irrigation water
Authors: Pérez‐Cataluña Alba , Randazzo Walter , Martínez‐Blanch Juan F. , Codoñer Francisco M. , Sánchez Gloria 
Published: February 2023

AbstractBACKGROUNDThe virome (i.e. community of mainly RNA and DNA eukaryotic viruses and bacteriophages) of waters is yet to be extensively explored. In particular, the virome of waters used for irrigation could therefore potentially carry viral pathogens that can contaminate fresh produce. One problem in obtaining viral sequences from irrigation waters is the relatively low amount of virus particles, as well as the presence of human, bacterial and protozoan cells. The present aimed study was to compare different processing, amplification, and sequencing approaches for virome characterization in irrigation waters.RESULTSOur analyses considered percentages of viral reads, values for diversity indices and number of families found in sequencing results. The results obtained suggest that enrichment protocols using two (bezonase and microccocal nuclease) or four enzymes at once (bezonase, microccocal nuclease, DNAse and RNase), regardless of an Amicon filtration step, are more appropriate than separated enzymatic treatments for virome characterization in irrigation water. The NetoVIR protocol combined with the ScriptSeq v2 RNA‐Seq Library (P0‐L20 protocol) showed the highest percentages of RNA viruses and identified the higher number of families.CONCLUSIONAlthough virome characterization applied in irrigation waters is an important tool for protecting public health by informing on circulating human and zoonotic infections, optimized and standardized procedures should be followed to reduce the variability of results related to either the sample itself and the downstream bioinformatics analyses. Our results show that virome characterization can be an important tool in the discovery of pathogenic viruses in the environment and can be used to inform and optimize reference‐based detection methods provided that appropriate and rigorous controls are included. © 2023 The Authors. Journal of The Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
Postoperative Chyle Leak Rate Following Neck Dissection for Squamous Cell Carcinoma Versus Papillary Thyroid Cancer
Authors: Baker Austin , Tassone Patrick , Dooley Laura M. , Galloway Tabitha I. , Zitsch Robert P. 
Published: February 2023

ObjectivesCompare the rates of post‐operative chyle leak following therapeutic lateral neck dissection during treatment of papillary thyroid carcinoma (PTC) versus squamous cell carcinoma (SCC) of the head and neck.MethodsA retrospective analysis of 226 consecutive neck dissections in 201 patients who underwent therapeutic neck dissection involving at least levels II‐IV with a final pathologic diagnosis of mucosal SCC of the head and neck or PTC from 2010 to 2020. Specific cases of chyle leak were reviewed. Surgical factors associated with chyle leak were analyzed using logistic regression analysis. Duration of chyle leak was assessed by the Kaplan–Meier curve, and time‐to‐resolution was analyzed by Cox proportional hazard analysis.ResultsPostoperative chyle leak was encountered in 15 (6.6%) neck dissections, eight (12.3%) in PTC, and seven (4.3%) in SCC. High‐volume chyle leak and chyle leak requiring operative intervention were only encountered in neck dissections performed for PTC. Chyle leak was significantly associated with PTC on univariable analysis (OR 3.08, p = 0.037), but not on multivariable analysis (OR 1.35, p = 0.711). High‐volume chyle leak and the need for operative intervention were associated only with PTC patients (OR 23.6, p = 0.006; OR 18.09, p = 0.023 respectively). Median duration of chyle leak was 12.1 days among patients with SCC, and 20.5 days among patients with PTC (p = 0.089).ConclusionsAmong 201 patients undergoing therapeutic neck dissection, chyle leak was associated with PTC pathology on univariable but not multivariable analysis. However, high‐volume leaks and leaks requiring operative intervention only occurred among patients with PTC.Level of evidencelevel III Laryngoscope, 133:2959–2964, 2023
Conservation and Sustenance of Natural Resources; Creating Awareness through Social Media amongst Rural Population in Greater Noida
Authors: Girdhar Divya , Srivastava Sonali 
Published: February 2023

AbstractEarth is the only planet that supports life with abundant natural resources. However, industrial explosion in the past few decades have led to depletion of many natural resources. The dependency of life is majorly supported by fresh water, which is the most important natural resource. In today's world of fast depleting resources, there is a need to discover methods and awareness programmes to support conservation and sustenance of natural resources. This study emphasizes on awareness amongst rural population that accounts to 136.64 crores as per the census survey of 2019; rural population is 68.84% which is not a negligible number. Owing to the size of the rural population, it is imperative to create awareness about the environmental aspects and remedies so they can learn and further it as a legacy to coming generations. Social media plays a very vital role in everyday life and can be used as an important tool to spread awareness with great efficiency. This research aims to find out the level of awareness regarding “Swachh Bharat Abhiyan” among rural people through social media. In this study, researcher will explore the dependency of social media, attain knowledge, and resolve issues. This study will emphasize on the water cleanliness issue highlighting prominent campaign of “Swachh Bharat Abhiyan” through social medium tools (WhatsApp, Instagram, Twitter, Facebook, MoJo, MaxTakatak, and YouTube) to get comprehensive results. In this study, four villages will be covered, and one hundred rural people will be the target audience. Finally, researcher concludes that social medium tools can create effective role in awareness of environmental issues that can encourage rural people to understand critical environment situations and strategically handle with care for the safe environment. As a result, better awareness programmes can be developed for the rural population through social media.
Microstructural Characteristics of ECR Plasma Etched and Heat Treated Commercial Copper Foil
Authors: Karmakar Samit , Kundu Soumik Kumar , Bandyopadhyay Sujit Kumar , Taki Gouranga Sundar 
Published: February 2023

AbstractThe structural quality of the catalytic transition metal substrate plays a critical role in pristine graphene synthesis by chemical vapor deposition. In this work, the microstructural parameters of commercial copper foils are investigated in lieu of conventional laboratory grade crystalline copper foils. Initially, the commercial copper foils are simultaneously plasma etched and heat treated for a period of 30, 45 min, and 1 h respectively at two elevated temperature levels of 823 and 923 K under the exposure of hydrogen plasma. The experiments are carried out in a 2.45 GHz Electron Cyclotron Resonance (ECR) Plasma Enhanced Chemical Vapor Deposition (PE‐CVD) reactor, at an operating pressure of 5 × 10−2 mbar. X‐ray diffraction (XRD) results are plotted and analyzed by Williamson–Hall (W–H) method to determine microstructural parameters, e.g., micro‐strain, stress, average domain size, and energy density associated to the processed copper foils.
Crystallinity Study of Cu Thin Film Deposited by Indigenously Developed DC Magnetron Sputtering Setup
Authors: Kundu Soumik Kumar , Karmakar Samit , Taki Gouranga Sundar 
Published: February 2023

AbstractThe copper thin films have a huge application in the field of material science research and they also act as a catalytic substrate which helps to deposit various carbon‐based polymers that can be used for sensors. There are several thin film development techniques available in the industries out of which magnetron sputtering technique shows some remarkable properties essential for depositing metal thin film efficiently. The main objective of this work is to develop copper thin films utilizing an indigenously designed and developed DC magnetron sputtering system. The X‐ray diffraction (XRD) pattern of the developed thin films display prominent peaks of copper (111) plane along with cuprous oxide (110), (111), and (220), respectively. This work also aims to study in detail the crystallinity of the deposited copper thin films by analyzing the XRD results for optimization.
Arduino Based Multisensor Smart Monitoring Device for Electrical Appliances
Authors: Rani Sonia , Sahni Mohit , Chauhan Lalit , Mehra Ram Mohan , Chauhan Sunil , Gupta Pankaj , Gupta Piyush Kumar 
Published: February 2023

AbstractThe project is an internet of things (IOT) based system that is devised to save power consumption. According to Environmental Impact Assessment (EIA) a report of Indian residential consumption, considering two lights and two fans, ON for 12 hours per day in the household approximately usage of electricity is 72 unit (kWh) per month. It is believed that from this project at least 20% of electricity can be saved per day which can be supplied to other households. The project is designed and interfaced with some components such as infrared (IR) sensors, motors, etc. with an Arduino microcontroller that controls the room lights and fans as well as counts the number of persons inside the room very accurately. The system can automatically switch ON room lights and fans when at least one person enters the room. If the person leaves the room, the lights and fans automatically get switched OFF. Thus, it can be used to prevent unwanted electric power wastage in schools/colleges/offices/ malls/houses and is a promising project for the conservation of energy which is quite helpful for the environment.
Building Automation Using Wireless Sensor Networks
Authors: Agumadu Chidozie , Lata Suma , Jaiswal Shiva Pujan 
Published: February 2023

AbstractThe use of wireless senor networks in building automation is gaining popularity so as to improve the safety, security, and energy efficiency of the buildings. The automation solution will differ as per the type of building. In this paper, authors have proposed three wireless sensor network (WSN) based automation solutions for buildings of different sizes. First strategy has been proposed for a small building using a single network. Second one is for a large building complex using multiple networks and third strategy is for building automation solution for local individual control. For building automation both monitoring and control of the parameters of interest are required. Authors have implemented first strategy in a small room of 501.9 m length and 410.9 m breadth. The humidity temperature and pressure (HTP) and TL sensor nodes of Eigen Technologies Ltd. have been used in this research work. HTP sensor node has been used for monitoring of humidity, temperature, and pressure. However, for the monitoring of luminosity TL sensor node has been chosen. Four sensor nodes of each type have been placed at appropriate locations in the selected room. Finally, a general control strategy for the temperature control has been proposed for the control of the building automation of a small building.
Characterization of Lignin Peroxidase from Cryptococcus neoformans for Bioremediation of Pulp and Paper Mill Effluent
Authors: Singh Pratibha , Srivastava Nupoor , Sharma Vivek 
Published: February 2023

AbstractEight fungal strains (F1–F8) isolate from the sediment core and degraded wood of the Pulp and Paper Mill effluent and Phanerochaete chrysosporium are tested for different cellulolytic (CMcase, FPase, Xylanases) and lignolytic (lignin peroxidase) enzyme activity in pulp. F‐3 (Cryptococcus neoformans) strain shows higher enzyme activity compare to other fungi isolated from effluent. Weight loss, cellulose loss, and organic carbon contents are found maximum in F‐3 (C. neoformans) strain. Reducing sugar, protein content, and color removing potential are also higher in C. neoformans. The culture extract of F‐3 strain grows in presence of pulp fractionated into five protein fractions has indicated two fractions of molecular weight, 38,000 and 40,000 Da, having lignin peroxidase activity. Lignin peroxidase has optimum activity at pH 2–3 and temperature 20–30 °C, maximum activity at 6–48 mM veratryl alcohol concentration and 256 mM H2O2, however, sodium azide inhibits the enzyme activity. Different metals (CoCl2, HgSO4, CaCl2, SnCl2, FeSO4, CuSO4, and ZnSO4) also affect the lignin peroxidase activity. Characterization study is performed for significant analysis.
Nano‐Biofortification of Zinc in Potato (Solanum tuberosum L.) and Tomato (Solanum lycopersicum L.) Crops
Authors: Singh Amardeep , Shukla Gyanika , Gaurav Shailendra Singh , Rani Poonam 
Published: February 2023

AbstractThe present study is carried out to establish the biofortification of zinc in potato (Solanum tuberosum L.) and tomato (Solanum lycopersicum L.) plants through the application of zinc oxide nanoparticles (ZnONPs). The mycogenic ZnONPs are synthesized by using Aspergillus flavus biomass and characterized to ascertain the size, shape, and concentration of synthesized nanoparticles. The ZnONPs are applied by foliar spray to the field‐grown potato and tomato crops and the biofortification level is recorded by Atomic Absorption Spectroscopy (AAS). A nanotoxicity assessment is done by comparing the amount of cell death and accumulation of reactive oxygen species (ROS) in control and ZnONPs treated plants. The AAS analysis reveals significant accumulation of the zinc in leaves of potato plants but insignificant accumulation is observed in the tubers. However, a significant accumulation of zinc is observed in the leaves and fruits of the tomato plants (p ≤ 0.05). The nanotoxicity evaluation studies show comparable and statistically insignificant toxicity in control plants as compared to plants treated with ZnONPs. The study concludes that biofortification through the means of ZnONPs is a cost‐effective and eco‐friendly approach that can be used as an alternative to the hazardous chemical zinc fertilizers.
Structural and Optical Properties of Cadmium Sulfide (CdS) Nano‐Powder
Authors: Yadav Satish Kumar , Vishwakarma Ankit Kumar , Yadava Lallan 
Published: February 2023

AbstractThe field of nanomaterials has been extensively identified as one of the most promising and rapidly emerging research areas. In this paper, the structural and optical properties of cadmium sulfide (CdS) powder samples are studied. Undoped CdS powder samples are prepared and characterized by X‐ray diffraction, Raman spectroscopy, and UV‐visible spectra. The structural properties are analyzed using X‐ray diffractometry. The estimated crystallite size of the sample is 28.2 nm calculated from the FWHM of the most intense peak (1 0 1). The optical properties are studied by the ultraviolet‐visible absorption spectrum. It is evident from UV‐visible absorption spectra that the optical band‐gap of the CdS sample is 2.27 eV which is estimated using the Tauc formula.
Power Quality Enhancement Using Passive Power Filters
Authors: Varshney Gunjan , Mittal Udit , Pawar Abhilasha 
Published: February 2023

AbstractHarmonics in Power system are dangerous in electrical distribution power systems. Harmonics in the line current promotes instability, losses and also the voltage distortion. Due to properties of power electronics converters, power lines have become highly polluted. The problems of bad power quality are due to higher switching frequencies and the non‐linearity properties of power electronic devices. So, to compensate these problems priority is being given to the development of Power Filters. Both types of filters, i.e., passive and active are often used for harmonics producing load to avoid distortions. Shunt type filters influences the harmonic reduction at medium or high voltage level, whereas active filters have been declared for low or medium voltage ratings. Along distinct applications consisting the reactive power and harmonics compensation, passive filters are found to be suitable. Passive filters have been adopted for harmonic compensation in distribution systems due to low cost, integrity, reliability, and controls less operation. Therefore, to mitigate these harmonics, different topologies of passive filters are designed and their different combined performances in MATLAB/Simulink are evaluated. The filter can compensate harmonic currents, reactive power, and power factor. The simulation results presented in this research show that the proposed approach can provide good dynamic and steady‐state performance.
Fabricating Plant Extract Mediated Silver Doped Bismuth Oxybromide (BiOBr‐G‐Ag) Photocatalyst for Wastewater Treatment
Authors: Garg Seema , Chawla Harshita , Banerjee Shalini 
Published: February 2023

AbstractHerein the fabrication of bismuth oxybromide‐silver doped photocatalyst using green route replacing toxic chemicals at 80 °C, further characterizing and studying of potential applications of fabricated nanoparticles is reported. Atomic force microscopy (AFM), scanning electron microscopy (SEM), degradation studies of methyl orange are studied using UV–vis absorption spectroscopy are performed to characterize the different nanoparticles that are synthesized. The properties of as‐fabricated catalysts are assessed using above characterization techniques reflect clover leaf like structure with higher surface area. The many‐fold increase in degradation activity of methyl orange is attributed to increase in OH groups due to phytochemicals present in plant extract of neem.