bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comorbidity in Congenital Hypothyroidism—A Nationwide, Population-based Cohort Study
Authors: Danner Emmi , Jääskeläinen Jarmo , Niuro Laura , Huopio Hanna , Niinikoski Harri , Viikari Liisa , Kero Jukka , Sund Reijo 
Published: June 2023

Abstract

Context
Patients with congenital hypothyroidism (CH) are affected more often than the general population by other chronic diseases and neurological difficulties.

Objective
The aim of this nationwide population-based register study was to investigate the incidence of congenital malformations, comorbidities, and the use of prescribed drugs in patients with primary CH.

Methods
The study cohort and matched controls were identified from national population-based registers in Finland. All diagnoses from birth until the end of 2018 were collected from the Care Register, and subject-specific prescription drug purchases were identified from The Prescription Register from birth until the end of 2017.

Results
Diagnoses of neonatal and chronic diseases were collected for 438 full-term patients and 835 controls (median follow-up time 11.6 years; range, 0-23 years). Newborns with CH were more often found to have neonatal jaundice (11.2% and 2.0%; P &lt; .001), hypoglycemia (8.9% and 2.8%; P &lt; .001), metabolic acidemia (3.2% and 1.1%; P = .007), and respiratory distress (3.9% and 1.3%; P &lt; .003) as compared to their matched controls.
Congenital malformations were diagnosed in 66 of 438 (15.1%) CH patients and in 62 of 835 (7.4%) controls (P &lt; .001). The most commonly affected extrathyroidal systems were the circulatory and musculoskeletal systems. The cumulative incidence of hearing loss and specific developmental disorders was higher among CH patients than controls. The use of antidepressant and antipsychotic drugs was similar in CH patients and their controls.

Conclusion
CH patients have more neonatal morbidity and congenital malformations than their matched controls. The cumulative incidence of neurological disorders is higher in CH patients. However, our results do not support the existence of severe psychiatric comorbidity.
Blood Cell Parameters From Early to Middle Pregnancy and Risk of Gestational Diabetes Mellitus
Authors: Ye Yi-Xiang , Wang Yi , Wu Ping , Yang Xue , Wu Linjing , Lai Yuwei , Ouyang Jing , Li Yanqin , Li Peishan , Hu Yayi , Wang Yi-Xin , Song Xingyue , Yan Shijiao , Lv Chuanzhu , Liu Gang , Pan An , Pan Xiong-Fei 
Published: June 2023

AbstractContextChronic low-grade inflammation may play a crucial role in the pathogenesis of gestational diabetes mellitus (GDM). However, prospective studies on the relations of inflammatory blood cell parameters during pregnancy with GDM are lacking.ObjectiveTo prospectively investigate the associations of inflammatory blood cell parameters in both early and middle pregnancy, and their change patterns from early to middle pregnancy, with GDM risk.MethodsWe used data from the Tongji-Shuangliu Birth Cohort. Inflammatory blood cell parameters (white blood cells [WBC], neutrophils, lymphocytes, monocytes, neutrophil to lymphocyte ratio [NLR], and platelets) were assayed before 15 weeks and between 16 and 28 weeks of gestational age. Logistic regression was used to evaluate the associations between inflammatory blood cell parameters and GDM.ResultsOf the 6354 pregnant women, 445 were diagnosed with GDM. After adjustment for potential confounders, WBC, neutrophils, lymphocytes, monocytes, and NLR in early pregnancy were positively associated with GDM risk (odds ratios [95% CI] for extreme-quartile comparison were 2.38 [1.76-3.20], 2.47 [1.82-3.36], 1.40 [1.06-1.85], 1.69 [1.27-2.24], and 1.51 [1.12-2.02], respectively, all P for trend ≤ .010). Similarly, higher levels of WBC, neutrophils, monocytes, and NLR in middle pregnancy were associated with increased risk of GDM (all P for trend ≤ .014). Stable high levels (≥ median in both early and middle pregnancy) of WBC, neutrophils, monocytes, and NLR were positively associated with GDM risk (all P ≤ .001).ConclusionIncreased WBC, neutrophils, monocytes, and NLR in both early and middle pregnancy and their stable high levels from early to middle pregnancy were associated with higher GDM risk, highlighting that they might be clinically relevant for identifying individuals at high risk for GDM.
Associations of Serum 25(OH)D With Risk of Recurrent Cardiovascular Events in Individuals With Coronary Heart Disease
Authors: Lin Xiaoyu , Chen Xue , Liu Sen , Deng Yulei , Wang Yuexuan , Lu Qi , Li Rui , Ou Yunjing , Tian Qingying , Liao Yunfei , Cui Guanglin , Yang Kun , Pan An , Liu Gang 
Published: June 2023

Abstract

Context
Few studies have examined the relationship between vitamin D and the risk of recurrent cardiovascular (CV) events in people with coronary heart disease (CHD).

Objective
This study aimed to investigate the associations of serum 25-hydroxyvitamin D (25(OH)D) concentration and the vitamin D receptor (VDR) polymorphisms with the risk of recurrent CV events in individuals with established CHD.

Methods
A total of 22 571 participants with CHD were included from the UK Biobank. Recurrent CV events, including myocardial infarction (MI), heart failure (HF), stroke, and CV disease mortality, were identified from electronic health records. Cox proportional-hazard models were used to calculate hazard ratios (HRs) and 95% CIs.

Results
The median (interquartile range) of serum 25(OH)D concentration was 44.8 nmol/L (range, 30.3-61.4 nmol/L), and 58.6% of participants had 25(OH)D below 50 nmol/L. During a median follow-up of 11.2 years, a total of 3998 recurrent CV events were documented. After multivariable adjustment, there was a nonlinear inverse relationship between serum 25(OH)D and recurrent CV events (P nonlinearity &lt;.01), and the decreasing risk gradually leveled off at around 50 nmol/L. Compared with participants with serum 25(OH)D less than 25.0 nmol/L, the HRs (95% CIs) for participants with serum 25(OH)D of 50.0 to 74.9 nmol/L were 0.64 (0.58-0.71) for recurrent CV events, 0.78 (0.65-0.94) for MI, 0.66 (0.57-0.76) for HF, and 0.66 (0.52-0.84) for stroke. In addition, these associations were not modified by genetic variants in the VDR.

Conclusion
In people with established CHD, higher serum 25(OH)D concentrations were nonlinearly associated with a lower risk of recurrent CV events, with a potential threshold around 50 nmol/L. These findings highlight the importance of maintaining adequate vitamin D status in the prevention of recurrent CV events among individuals with CHD.
Stressed Microglia: Neuroendocrine–Neuroimmune Interactions in the Stress Response
Authors: Sequeira Michelle K , Bolton Jessica L 
Published: June 2023

Abstract
Stressful life experiences are associated with the development of neuropsychiatric disorders like depression. Emerging evidence indicates that microglia, the specialized resident macrophages of the brain, may be a key mediator of the relationship between psychosocial stressor exposure and adaptive or maladaptive responses at the level of synaptic, circuit, and neuroimmune alterations. Here, we review current literature regarding how psychosocial stressor exposure changes microglial structure and function, thereby altering behavioral and brain outcomes, with a particular focus on age- and sex-dependent effects. We argue that additional emphasis should be placed in future research on investigating sex differences and the impacts of stressor exposure during sensitive periods of development, as well as going beyond traditional morphological measurements to interrogate microglial function. The bidirectional relationship between microglia and the stress response, particularly the role of microglia in the neuroendocrine control of stress-related circuits, is also an important area for future investigation. Finally, we discuss emerging themes and future directions that point to the possibility of the development of novel therapeutics for stress-related neuropsychiatric disorders.
The Physiocratic Analysis of Money: A Reappraisal
Authors: Menuet Maxime , Villieu Patrick 
Published: June 2023

Abstract
Few studies have focused specifically on the physiocratic analysis of money. The physiocrats' position was based on their criticism of Law's system and more broadly on the role of finance. First, they rejected the idea that a large amount of money was the condition for the wealth of nations. Second, they rejected paper money, as well as any form of currency alteration. As a simple means of exchange, Quesnay and his followers recognized that money could be replaced by paper. However, in order to comply with the “value for equal value” principle of exchange, money had to be made of precious metals, as Le Trosne, the main architect of the physiocratic monetary doctrine, forcefully asserted. This doctrine of money created a tension: from the circulation perspective, money was not considered as a component of wealth and could be replaced by paper to simply represent flows in expenditure; but from the equality-of-exchange perspective, money had to be made of precious metals, thus becoming a storable asset in a portfolio. To overcome this tension, the économistes were to forcefully denounce hoarding and deny money the function of a store of value.
Tax Erosion in Seventeenth-Century Naples: Tommaso Campanella on Causes and Remedies
Authors: Costabile Lilia , Velde François R. 
Published: June 2023

Abstract
Writing in the first decade of the seventeenth century, Tommaso Campanella (1568–1639) studied tax erosion and proposed remedies that he promised would “transform a harm into a benefit.” The factual evolution of tax revenues and prices under the monetary and fiscal systems of his time confirms his diagnosis. A simple model built on his assumptions shows how clipping produces tax erosion in a commodity money system, and it illustrates how Campanella's plan not only eliminates this harm but also produces the benefit of higher government purchases at the expense of rentiers. A broader reading of his work clarifies the distributional implications of his proposal in the light of his radical egalitarianism and his goal of a united, harmonious society.
A triple helix model for the diffusion of Industry 4.0 technologies in firms in the Marche Region
Authors: Testi Niccolò 
Published: June 2023

Background: Firms in the Marche Region, Italy, seem to struggle with understanding the importance of Industry 4.0 technologies, including blockchain technology, and delay the adoption of these innovative technologies. Methods: This paper is based on findings of three levels of qualitative analysis: the first one is a literature review; the second uses secondary sources about the diffusion of Industry 4.0 in the Marche Region and the local institutions and policies favouring it, retrieved from institutional websites and web searches; the third uses primary data which has been collected through an explorative survey conducted by sending a questionnaire to local innovative firms between 25th and the 27th of October 2022. Results: The literature review shows that collaboration between triple helix actors can foster innovation in firms. Secondary data about firms in the Marche Region describes an economy made prevalently of micro enterprises not capable of adopting Industry 4.0 technologies, and individuates some institutions located in the region having the role of innovation intermediaries that help firms innovate. Among the secondary sources, the new Smart Specialisation Strategy 2021-2027 of the Marche Region emphasises the role of Industry 4.0 for economic development which requires the involvement of the research and innovation actors present in the region. The survey conducted for this study shows that the firms that adopted Industry 4.0 technologies have strong ties and collaboration with triple helix institutions. Conclusions: Based on the findings, a triple helix model is proposed to foster the diffusion of Industry 4.0 technologies in the Marche Region, where innovation intermediaries are called to manage knowledge flows both among them and between academia, government, and industry, to activate a virtuous cycle of innovation adoption and valorisation.
DEVELOPMENT OF A MATHEMATICAL MODEL AND AN AUTOMATED ALGORITHM FOR CALCULATING THROUGHPUT
Authors: Pokrovskaya O. D. , Marchenko M. A. , Kukushkina Ya. V. 
Published: June 2023

Background. The problem of this work is to develop a methodology for calculating cash throughput, which is based on the well-known formulas for calculating cash throughput, the main innovation of which is to take into account the time spent by trains on acceleration and deceleration en route. Currently, in the process of calculating the available capacity, a formal approach is used to determine the removal coefficients, and the site speed is also taken into account, calculated taking into account acceleration and deceleration, but representing only the ratio of the length of a certain section of the railway polygon to the time of the train following it.
Materials and/or methods: simulation modeling, economic and mathematical modeling, AnyLogic software package, methods of general systems theory, logistics.
Results. An analytical formula is proposed that allows calculating the available throughput with higher accuracy. The results of the study can be used in the dispatch centers of transportation management of JSC “Russian Railways” in order to more fully analyze the operation of the landfill of the road, railway lines or individual sections in order to more fully analyze the work performed on transportation.
Conclusion. The article develops a methodology for calculating the available capacity on a railway line with full consideration of the effect of acceleration and braking of trains on their way to the resulting available capacity.
Effect of morphological evolution and aggregation of plasmonic core-shell nanostructures on solar thermal conversion
Authors: Xing Linzhuang , Wang Ruipeng , Ha Yuan , Li Zhimin 
Published: June 2023

Achieving high solar energy absorption based on nanofluids (NFs) needs further study in solar photothermal conversion technology. In this work, we performed COMSOL simulations to investigate the solar energy absorption using a core-shell nanostructure composed of the Au core and shell with different materials. The influence of the radius of the Au core, the materials of the shell, and the shell thickness on the solar absorption efficiency factor (SAEF) are systematically studied. The results show that the SAEF of the Au@Li nanoparticle with ratio of 0.5 has the highest SAEF of 1.4779, increasing 1.99 times compared to that of the bare Au nanoparticle of 0.74326 with the same radius. Moreover, the optical properties, electric field distribution, and SAEF of the Au@Li dimer are further evaluated to demonstrate the aggregation effects on SAEF. We find that the SAEF of the Au@Li dimer reaches the maximum of 4.34 with a distance around 1 nm, where the LSPR coupling effect in the nanogap is sharply enhanced 700 times irradiated by light with wavelength of 760 nm. Finally, the direct absorber solar collector performance demonstrates that Au@Li dimer NFs can collect 93% of solar energy compared to 54% for Au@Li NFs and 51% for Au NFs. This work provides the possibility to achieve more efficient solar thermal conversion, and may have potential applications in efficient solar energy harvesting and utilization.
Diffuse-Type Pancreatic Ductal Adenocarcinoma Mimicking Autoimmune Pancreatitis
Authors: Chow Kenneth W. , Hu Steve , Sikavi Cameron , Bell Matthew T. , Gisi Brandon , Chiu Richard , Yap Caroline G. , Eysselein Viktor , Reicher Sofiya 
Published: June 2023

ABSTRACT
Pancreatic ductal adenocarcinoma (PDAC) classically presents as a solitary mass on cross-sectional imaging. Diffuse-type PDAC is an unusual variant that accounts for 1%–5% of PDACs. Owing to its rarity, there are no established radiographic or endosonographic definitions. We report a unique case of diffuse-type PDAC presenting with imaging findings of 2 distinct masses in the pancreatic head and tail and with endoscopic ultrasound findings of diffuse gland enlargement mimicking autoimmune pancreatitis. The case illustrates the importance of sampling several areas of the pancreas when diffuse enlargement is present on endoscopic ultrasound and multiple masses are seen on cross-sectional imaging.
Hyperbilirubinemia in a Patient With Sepsis: A Diagnostic Challenge
Authors: Shah Yash R. , Singh Dahiya Dushyant , Chitagi Pritha , Rabinowitz Loren G. 
Published: June 2023

ABSTRACT
Cholestasis due to sepsis is commonly seen in critically ill patients; however, it is often overlooked and poses a challenge in clinical diagnosis and management. In this report, we present a 29-year-old woman who presented to the emergency department with jaundice and symptoms of a urinary tract infection. Initially suspected to be Dubin-Johnson syndrome, sepsis-induced cholestasis was eventually diagnosed after testing. Sepsis should always be considered as part of the differential diagnosis while managing a patient with jaundice. The management of sepsis-induced cholestasis involves treating the underlying infection. In most cases, liver injury improves with the resolution of the infectious process.
Diminutive Colon Metastasis From Breast Cancer: An Unexpected Finding in a Patient Undergoing Ulcerative Colitis Surveillance
Authors: Stefanopoulos Anastasios , Telakis Emmanouil , Zlatinoudis Charalampos , Theodoulou Aggelos , Tzaida Olympia , Filippakou Aikaterini , Tsironi Eftychia 
Published: June 2023

ABSTRACT
Metastatic lesions to the colon are far less common than primary tumors. Breast cancer metastasis to the colon is rarely reported, and it is often atypical in presentation and difficult to diagnose. We present a case of a diminutive asymptomatic breast cancer metastasis to the colon found during surveillance colonoscopy in a patient with long-lasting ulcerative colitis, which was initially regarded as a colitis-associated dysplastic lesion. Because early detection of metastatic disease plays a key role in the treatment of patients with breast cancer, a high index of suspicion must be maintained for atypical metastatic presentations to the gastrointestinal tract.
Ekstraksi Daun Salam Berbasis Natural Deep Eutectic Solvent dan Pemanfaatannya sebagai Antioksidan
Authors: Rahman Muhammad Kevin , Fachriyah Enny , Kusrini Dewi 
Published: June 2023

Daun salam (Syzygium polyanthum) merupakan salah satu tanaman yang sering digunakan sebagai obat. Daun salam mengandung senyawa metabolit sekunder golongan tanin, alkaloid, steroid, flavonoid, triterpenoin, saponin, monoterpen, kuinon, dan seskuiterpen. Daun salam biasa dimanfaatkan sebagai pengobatan tradisional karena memiliki aktivitas farmakologis antara lain : antihipertensi, antimikroba, dan antidiare. Penelitian ada beberapa tahapan yaitu skrining fitokimia pada simplisia dan ekstrak, sintesis NADES dengan metode pengadukan dan pemanasan, uji fisikokimia NADES berupa uji densitas dan viskositas terhadap suhu, ekstraksi berbantu ultrasonik dengan menggunakan pelarut etanol dan NADES, uji TPC dengan metode Folin-Ciocalteu, uji TFC dengan metode kompleks AlCl3, uji aktivitas antioksidan dengan metode DPPH, serta penentuan besarnya korelasi TPC dan TFC dengan aktivitas antioksidan (IC50) menggunakan korelasi Pearson. Hasil ekstraksi berkisar 22-52% (v/v). Pelarut NADES ChCa memiliki nilai densitas dan parameter viskositas tertinggi sebesar 1,22 g/mL dan 1,171 mPa.s. Hasil uji TPC menunjukkan ekstrak ChOa memiliki nilai tertinggi sebesar 278,292 ± 25,5257 mg GAE/g sampel. Hasil uji TFC menunjukkan ekstrak etanol memiliki nilai tertinggi sebesar 6,579 ± 0,450 mg QE/g sampel. Ekstrak ChOa memiliki aktivitas antioksidan terkuat dengan nilai IC50 sebesar 5,657 mL/L. Terdapat korelasi yang kuat antara kandungan total fenol dengan nilai IC50.
miR-141-3p accelerates ovarian cancer progression and promotes M2-like macrophage polarization by targeting the Keap1-Nrf2 pathway
Authors: Zhao Jingyun , Liu Leilei , Zhao Wei , Lv Cuiting , Zhang Na , Jia Xinzhuan , Zhang Zhengmao 
Published: June 2023

Abstract
The miR-141-3p has been reported to participate in regulating autophagy and tumor-stroma interactions in ovarian cancer (OC). We aim to investigate whether miR-141-3p accelerates the progression of OC and its effect on macrophage 2 polarization by targeting the Kelch-like ECH-associated protein1-Nuclear factor E2-related factor2 (Keap1-Nrf2) pathway. SKOV3 and A2780 cells were transfected with miR-141-3p inhibitor and negative control to confirm the regulation of miR-141-3p on OC development. Moreover, the growth of tumors in xenograft nude mice treated by cells transfected with miR-141-3p inhibitor was established to further testify the role of miR-141-3p in OC. The expression of miR-141-3p was higher in OC tissue compared with non-cancerous tissue. Downregulation of miR-141-3p inhibited the proliferation, migration, and invasion of ovarian cells. Furthermore, miR-141-3p inhibition also suppressed M2-like macrophage polarization and in vivo OC progression. Inhibition of miR-141-3p significantly enhanced the expression of Keap1, the target gene of miR-141-3p, and thus downregulated Nrf2, while activation of Nrf2 reversed the reduction in M2 polarization by miR-141-3p inhibitor. Collectively, miR-141-3p contributes to tumor progression, migration, and M2 polarization of OC by activating the Keap1-Nrf2 pathway. Inhibition of miR-141-3p attenuates the malignant biological behavior of ovarian cells by inactivating the Keap1-Nrf2 pathway.
Method for deriving twisting process parameters of large package E-glass yarn by measuring physical properties of bobbin yarn
Authors: Wang Xi , Chen Juanfen , Li Shuai , Xiao Pei , Cheng Kai , Wang Yanhe , Zheng Tianyong 
Published: June 2023

Abstract
Twisting is an important part in the production process of large package E-glass yarn. To derive the twisting process parameters of large package E-glass yarn, a method from the physical properties of bobbin yarn is proposed based on the study of the twisting principle of E-glass yarn. After unwinding the bobbin yarn and measuring its twist, loop pitch, and corresponding diameter, the calculation is completed according to the steps of first determining the descending speed of the traveler, then fitting the spindle speed data, and finally calculating the elevating speed of the traveler. The result is that the twisting spindle speed of D450 E-glass yarn with 31.8 T/m decreases from 5,015 to 4,550 rpm, the elevating speed of the traveler is 0.91 m/min, and the descending speed of the traveler is 1.50 m/min. The accuracy of the calculation is verified by monitoring the rotating speed of the roving cake and measuring the loop pitch of bobbin yarn in the twisting experiment. The result shows that the prediction error of this method is less than 1.1%, which can effectively derive the twisting process parameters of large package E-glass yarn, and provide a reference for the twisting process design scheme of glass fiber strand manufacturers.
Therapeutic Rites and Popular Religiosity in Southern Italy
Authors: Harwazinski Assia 
Published: June 2023

Zusammenfassung
To Paul Meyer and Les Films de l’Églantine, Belgium
Paul Meyer, filmmaker and documentarist, born September 29, 1920, died September 29, 2007 in Belgium. He had his own production company Les films de l´églantine in his hometown Barchon, Belgium. Due to lucky circumstances, I met him during the French Film Festival, Tübingen, in 1995 and am still in possession of a personal hand-written letter from him, dated August, 1995. Our talk is documented in Blickpunkt: Film of 17th July, 1995.

Der Beitrag beschreibt am Beispiel von vier Dokumentarfilmen exemplarisch die Arbeit und das Werk von Luigi di Gianni, einem wichtigen Vertreter visueller Anthropologie in Europa, Schüler von Ernesto de Martino und Paul Meyer. Die Arbeiten zeigen therapeutische Riten süditalienischer Volksreligiosität aus der Zeit zwischen den fünfziger Jahren bis in die erste Dekade des 21. Jahrhunderts hinein und würdigen das Werk di Giannis in seiner bisher vernachlässigten Bedeutung für die Religionswissenschaft und die Europäische Religionsgeschichte.