bluuebunny/crossref_metadata_2025_split huggingface dataset:
Level of JMP ladders for water, sanitation, and hygiene (WASH) services among healthcare facilities of Bishoftu Town, Ethiopia: An implication of healthcare-associated infection prevention status
Authors: Girmay Aderajew Mekonnen , Kenea Moa Abate , Mengesha Sisay Derso , Wagari Bedasa , Weldetinsae Abel , Alemu Zinabu Assefa , Dinssa Daniel Abera , Weldegebriel Mesaye Getachew , Serte Melaku Gizaw , Alemayehu Tsigereda Assefa , Teklu Kirubel Tesfaye , Adugna Ermias Alemayehu , Gobena Waktole , Fikresilassie Getinet , Tessema Masresha , Tollera Getachew 
Published: June 2023

Abstract

This study aimed to assess the level of JMP ladders for WASH services. A cross-sectional study was conducted. Forty-four healthcare facilities were enrolled. From each healthcare facility, water samples were collected directly from water storage facilities. In addition to the interview, an observational checklist was used. Descriptive statistics and a chi-square test were conducted to analyze the data. The coverage of advanced and basic drinking water services in healthcare facilities was 4.6 and 70.4%, respectively. However, the healthcare facilities’ access to advanced and basic sanitation services was nil. Similarly, 61.4 and 88.6% of the healthcare facilities had no hygiene and waste disposal services, respectively. While 2.6, 4.5, and 75% of healthcare facilities had advanced, basic, and limited environmental cleaning services, 18.2% lacked environmental cleaning services. Water samples of 15.9, 11.4, and 6.8% of the healthcare facilities were found positive for total coliforms, fecal coliforms, and E. coli, respectively. The WASH services of the healthcare facilities were very low and not on track to achieve the Sustainable Development Goal target. Healthcare facilities could be sources of healthcare-associated infections. Hence, the government and other concerned bodies should take urgent action to improve WASH services.
Defining sustainability in agricultural water management using a Delphi survey technique
Authors: Dahal Bishal , Avellán Tamara , Haghighi Ali Torabi , Kløve Bjørn 
Published: June 2023

Abstract

Sustainable water management measures are being developed to address the challenges posed by agriculture runoff and leaching on water resources. These measures are based on experts' opinions from various sectors and disciplines, ensuring that all stakeholders' perspectives are considered. For this, establishing a common understanding of 'sustainability' is essential to avoid misunderstandings, conflicts, and operational challenges. In this research, the Delphi survey technique was utilized to develop a definition of ‘sustainability’ in agricultural water management (SAWM) by considering the interdisciplinary group of experts from different parts of the world and those involved in a Horizon 2020 Research and Innovation Action. Twenty-six experts' perspectives on environmental, economic, and social dimensions of sustainability were assessed, and identified key concepts included climate change, water quality, water availability, stakeholder participation, capacity building, subsidies, and incentives. These concepts were used to define sustainability for multi/interdisciplinary project settings. The definition was validated with consortium members of the project in the regular consortium-wide meetings and used in the respective deliverables dealing with sustainability. The results serve as a foundation for communication between the involved actors and the project's definition of 'sustainability.' One recommendation from this work for broader policy formulation for SAWM in Europe is to prioritize farmer needs and focus on environmental sustainability.
Comparison of the adsorption capacity and mechanisms of mixed heavy metals in wastewater by sheep manure biochar and Robinia pseudoacacia biochar
Authors: Wang Siqi , Li Xin , Zhu Yali 
Published: June 2023

Abstract
Under various pyrolysis temperatures, the characteristics and heavy metal adsorption capabilities of biochar obtained from sheep manure (SMB) and Robinia pseudoacacia (RPB) were studied. The results indicated that SMB had higher yields, pH values, and ash contents than RPB. SMB3 and RPB3 have more oxygen-containing functional groups, whereas SMB8 and RPB8 have higher aromaticity and polarity. The maximum adsorption capacities of SMB for Pb2+ (20.2 mg·g−1), Cu2+ (13.9 mg·g−1), Cd2+ (3.2 mg·g−1), and total heavy metals (37.3 mg·g−1) were obtained by SMB3. However, the maximum adsorption capacities of RPB for Pb2+ (7.4 mg·g−1) and Cu2+ (10.5 mg·g−1) were obtained by RPB8. Furthermore, SMB and RPB had relatively higher adsorption capacities for Pb2+ and Cu2+ than for Cd2+. The pseudo-second-order model and the Freundlich Langmuir model provided a good fit to the adsorption kinetics and isotherms, indicating that chemical adsorption was dominant in the heavy metal adsorption by SMB and RPB. According to the contribution of various mechanisms, ion exchange and mineral precipitation were the primary mechanisms responsible for RPB8, while functional group complexation was the dominant mechanism for SMB3. This study provided important information on the comprehensive recycling utilization of SMB and RPB and promoted sustainable development.
Alkaloids as Potential Anti-HIV Agents
Authors: Rani Nidhi , Singh Randhir , Kumar Praveen , Sharma Prerna , Kaur Rajwinder , Arora Rashmi , Singh Thakur Gurjeet 
Published: June 2023

Background:
Alkaloids are nitrogen-containing compounds that are naturally occurring
and have a variety of biological activities, including antimicrobial properties. In this study, the authors
used a molecular docking approach to evaluate the anti-HIV potential of 64 alkaloids.

Methods:
The authors used the Molegro Virtual Docker software to dock the alkaloids into the active
sites of three HIV enzymes: protease, integrase, and non-nucleoside reverse transcriptase
(NNRT). The docking scores were used to assess the potential of the alkaloids to inhibit the enzymes.

Results:
The results showed the alkaloids to have good potential to inhibit the enzymes. Tubocurarine
and reserpine were found to be the most potent alkaloids, with docking scores of -123.776 and -
114.956, respectively.

Conclusion:
The authors concluded that tubocurarine and reserpine could be further promoted as
potential lead molecules for the development of new anti-HIV drugs.
Ionic liquid Supported Quinuclidine Catalyzed Morita-Baylis-Hillman
Reaction
Authors: Srivastava Vivek 
Published: June 2023

Abstract:
The Morita-Baylis-Hillman (MBH) reaction is an important method for forming carboncarbon
bonds between carbonyl-containing compounds and activated olefins. However, the slow reaction
rate with electron-rich electrophilic partners has limited its wider use. To overcome this drawback,
the effects of pyridinium-based ionic liquids mediated quinuclidine catalytic system for MBH
reactions were studied. The method is simple, involving neat and open-flask conditions, and is compatible
with a wide range of reagents. We offered general pyridinium-based ionic liquids-mediated
quinuclidine catalysis mechanism that is responsible for the observed rate increase. The synthetic versatility
of the MBH adducts is demonstrated by the synthesis of important building blocks for the natural
product (-)-sitophilure. The authors anticipate that this pyridinium-based ionic liquids-mediated
quinuclidine protocol could serve as a general methodology for the MBH reaction. In summary, the
study presents a simple and effective method to enhance the reaction rate of the MBH reaction. The
authors believe this method has the potential for broader applications and may contribute to developing
new synthetic strategies for organic synthesis. We successfully recycled the catalytic system up to
7 runs without losing any catalytic activity.
Methods of Assessment of Physical Capacity in People with Diabetes Mellitus
Type 1
Authors: Flotyńska Justyna , Szybiak Weronika , Naskręt Dariusz , Zozulińska-Ziółkiewicz Dorota , Grzelka-Woźniak Agata , Uruska Aleksandra 
Published: June 2023

Background:
The article aims to present the most popular methods of assessing physical
capacity. Moreover, the article sheds light on the beneficial impact of improving physical capacity
in people with Diabetes Mellitus type 1 (DM1).

Methods:
A computer-based literature search of PubMed, SCOPUS and Web of Science included
studies up to September 2022.

Results:
The significant role of regular physical exertion could be observed in the group of people
suffering from DM1, which implicates a positive correlation between the activity and the remission
time. A suitable and objective indicator of sport influence on the organism is physical capacity
(PC), which describes the efficiency of the cardiovascular system and its correlation between BMI,
sex, and age. PC is mostly shown as VO2max. Well metabolically controlled DM1 is not a contraindication
to stress test. Even though physical activity is closely related to human history, the range
of research into the importance of PC is still limited to particular groups of patients, which presents
an opportunity for further research and future conclusions.

Conclusions:
Undertaking physical activities has a multidirectional influence on the organism. According
to up-to-date knowledge, various methods of PC assessment are available. Patients can
choose more easily accessible, simpler, and cheaper options like CRT, RT, and HST which do not
need specialized equipment and skills. They can also decide on more advanced examinations like
ergospirometry, where direct measurements of VO2max and other cardiorespiratory parameters are
made.
Nutritional Value and Physical Quality of Oral Nutritional Supplements Made from Purple Sweet Potatoes to Treat Malnutrition in Patients with
Cancer
Authors: Kurniasari Fuadiyah Nila , Susetyowati Susetyowati , Hardianti Mardiah Suci , Cempaka Anggun Rindang 
Published: June 2023

Background:
Malnutrition often occurs in patients with cancer, which eventually leads
to decreasing response to therapy and increased morbidity and mortality rate. Oral Nutrition Supplements
(ONS) are necessary to provide additional nutritional intervention to prevent and treat
malnutrition in cancer patients. Purple sweet potato is a local food that is abundantly available in
Indonesia and can be utilized as a basic ingredient for producing a modified ONS formula that is
not only high in nutritional value but also has good physical quality.

Objective:
This study aimed to evaluate the nutritional value and physical quality of purple sweet
potato-based ONS.

Methods:
A new local food-based formula was formulated by using purple sweet potato as the main
ingredient. This new formula, which was then mentioned as the treatment formula, was subsequently
compared with the control formula. The control formula was made from ingredients commonly
used for producing ONS in hospitals in Indonesia, such as milk powder, sugar, oil, and other additives
such as maltodextrin and creamer. Meanwhile, the treatment formula was labelled into three
treatment formulas based on the differences in the proportions of white egg flour and whey protein
as a protein source in each treatment formula. The treatment formula was formulated by using local
ingredients of purple sweet potato flour and egg white flour by adding whey protein, extra virgin
olive oil, omega-3 powder, sugar, and creamer. A proximate analysis was conducted to analyze the
nutrient content of the formula and the viscosity and osmolarity tests were conducted to evaluate the
physical qualities of the formula. The laboratory analysis results were described as descriptive data,
then analyzed by using One-Way ANOVA. The determination of the best treatment formula in the
form of effectiveness (Nh).

Results:
The results of the proximate test and physical quality showed that the best formula based
on the highest Nh value of 0.75 was P3 with 245 kcal energy, 8.8 g (14%) protein, 6.5 g (24%) fat,
and 37.8 g (62%) carbohydrate, viscosity 28.1 cP, and osmolarity 492.3 mOsm (iso-osmolar) per
serving size (200 ml).

Conclusion:
Formula P3 which contains more egg white flour than whey protein is the best formula
that has the best nutritional value and good physical quality.
The Use of Midazolam as an Antiseizure Medication in Neonatal Seizures:
Single Center Experience and Literature Review
Authors: Falsaperla Raffaele , Collotta Ausilia Desiree , Sortino Vincenzo , Marino Simona Domenica , Marino Silvia , Pisani Francesco , Ruggieri Martino 
Published: June 2023

Background:
Existing therapeutic alternatives for neonatal crises have expanded in recent
decades, but no consensus has been reached on protocols based on neonatal seizures. In particular, little
is known about the use of midazolam in newborns.

Aim:
The aim of our study is to evaluate the response to midazolam, the appearance of side effects,
and their impact on therapeutic decisions.

Methods:
This is a STROBE-conformed retrospective observational study of 10 patients with neonatal
seizures unresponsive to common antiseizure drugs, admitted to San Marco University Hospital’s neonatal
intensive care (Catania, Italy) from September 2015 to October 2022. In our database search, 36
newborns were treated with midazolam, but only ten children met the selection criteria for this study.

Results:
Response was assessed both clinically and electrographic. Only 4 patients at the end of the
treatment showed a complete electroclinical response; they were full-term infants with a postnatal age
greater than 7 days. Non-responders and partial responders are all premature (4/10) or full-term neonates
who started therapy in the first days of life (< 7th day) (2/10).

Conclusion:
Neonatal seizures in preterm show a lower response rate to midazolam than seizures in
full-term infants, with poorer prognosis. Liver and renal function and central nervous system development
are incomplete in premature infants and the first days of life. In this study, we show that midazolam,
a short-acting benzodiazepine, appears to be most effective in full-term infants and after 7
days of life.
A Review on the Role of Nitric Oxide in the Pathophysiology and
Management of Sars- Cov-2 Disease
Authors: Chadha Sonia , Mukherjee Sayali , Sanyal Somali 
Published: June 2023

Abstract:
SARS-CoV-2, first emerged in December 2019 in Wuhan, China, and its rapid transmission
led to the declaration of a pandemic by WHO. Nitric oxide is involved in SARS CoV-2 disease and its
antiviral effects have prompted its use in the therapeutic management of SARS CoV-2. The effects of NO
are concentration dependent. Local and controlled production of NO by the constitutive nitric oxide synthase
appears beneficial, while overproduction due to inducible nitric oxide synthase may lead to cell
destruction and tissue damage. The review discusses the role of nitric oxide in the pathogenesis of
COVID-19 and its use as a probable therapeutic intervention preventing its progress to a more severe
form.
Web-Based Cognitive Bias Modification Program for Young People With Social Anxiety and Hazardous Alcohol Use: Feasibility, Acceptability, and Preliminary Efficacy Study
Authors: Prior Katrina , Salemink Elske , Piggott Monique , Manning Victoria , Wiers Reinout W , Teachman Bethany A , Teesson Maree , Baillie Andrew J , Mahoney Alison , McLellan Lauren , Newton Nicola C , Stapinski Lexine A 
Published: June 2023

Background
Interpretation bias modification (IBM) and approach bias modification (ApBM) cognitive retraining interventions can be efficacious adjunctive treatments for improving social anxiety and alcohol use problems. However, previous trials have not examined the combination of these interventions in a young, comorbid sample.

Objective
This study aims to describe the feasibility, acceptability, and preliminary efficacy of a web-based IBM+ApBM program for young adults with social anxiety and hazardous alcohol use (“Re-Train Your Brain”) when delivered in conjunction with treatment as usual (TAU).

Methods
The study involved a 3-arm randomized controlled pilot trial in which treatment-seeking young adults (aged 18-30 y) with co-occurring social anxiety and hazardous alcohol use were randomized to receive (1) the “integrated” Re-Train Your Brain program, where each session included both IBM and ApBM (50:50 ratio), plus TAU (35/100, 35%); (2) the “alternating” Re-Train Your Brain program, where each session focused on IBM or ApBM in an alternating pattern, plus TAU (32/100, 32%); or (3) TAU only (33/100, 33%). Primary outcomes included feasibility and acceptability, and secondary efficacy outcomes included changes in cognitive biases, social anxiety symptoms, and alcohol use. Assessments were conducted at baseline, after the intervention period (6 weeks after baseline), and 12 weeks after baseline.

Results
Both Re-Train Your Brain program formats were feasible and acceptable for young adults. When coupled with TAU, both integrated and alternating programs resulted in greater self-reported improvements than TAU only in anxiety interpretation biases (at the 6-week follow-up; Cohen d=0.80 and Cohen d=0.89) and comorbid interpretation biases (at the 12-week follow-up; Cohen d=1.53 and Cohen d=1.67). In addition, the alternating group reported larger improvements over the control group in generalized social anxiety symptoms (at the 12-week follow-up; Cohen d=0.83) and alcohol cravings (at the 6-week follow-up; Cohen d=0.81). There were null effects on all other variables and no differences between the intervention groups in efficacy outcomes.

Conclusions
Should these findings be replicated in a larger randomized controlled trial, Re-Train Your Brain has the potential to be a scalable, low-cost, and non–labor-intensive adjunct intervention for targeting interpretation and comorbidity biases as well as generalized anxiety and alcohol-related outcomes in the real world.

Trial Registration
Australian New Zealand Clinical Trials Registry ACTRN12620001273976; https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=364131

International Registered Report Identifier (IRRID)
RR2-10.2196/28667
PICTURES AS LEARNING – TEACHING AID IN IMPROVING ENGLISH VOCABULARY AT ELEMENTARY SCHOOL IN DENPASAR
Authors: Sumartini Ni Luh Putu Unix 
Published: June 2023

It has been researched in some studies and related theories confirming that using picture in teaching English vocabulary was very effective. Especially for young learner in elementary school which has Bahasa Indonesia as their main language, the vocabulary problem used to occurred in spelling, pronunciation, grammatical use, and meaning. Those language aspects become main obstacle for them. This research explores the implementation of English vocabulary and to find out the score improvement in using picture in learning process. The objective of this research is to find out the effectiveness of picture in improving students’ vocabulary. The research is conducted in Santo Yoseph 1 elementary school Denpasar in the class of 3B .It was conducted in two cycles to twenty-seven participants. Instruments used were tests, questionnaires, and observation. Results showed that an initial vocabulary mastery was 75.6 points, and increased to 86.08 in the final cycle of the study. In the same way, the questionnaire results in the second cycle revealed that although the students still found English learning (85.50) and memorizing vocabulary (70.37%) difficult, their interest in learning it increased (59.26% from 29.63%). Finally, the observation results of the second cycle also showed the improvement of both students’ and teacher’s teaching and learning atmosphere as well as interest. However, a further study and learning policy are worthy to assure the application of the pictorial aids facilitating the attractive and motivating learning atmosphere in the future.
Keywords: Secondary student, vocabulary, pictorial aid
Pushe eller puse – perspektiver på dramarommets paradoks
Authors: Bruun Ellen Foyn , Steigum Jorid Bakken 
Published: June 2023

I denne artikkelen presenteres funn fra en studie på programfag drama i norsk videregående skole. Dramalærere samt tidligere og nåværende dramaelever fra tre skoler ble intervjuet om hvordan de så på forholdet mellom dramarommet og psykisk helse. Av studien gikk det frem at dramarommet oppleves som et paradoks, både veldig fritt og krevende på samme tid. For å undersøke hvilke faktorer som kan bidra positivt og mulig negativt for elevenes psykiske helseopplevelse i dramarommet, tar vi utgangspunkt i en ressursorientert helseforståelse og bringer inn begrepet toleransevinduet fra psykologien. Dramarommets paradoks utdypes med tre perspektiver som spenningsfelt: mellom å bli pushet og ivaretatt, mellom innlevelse og distanse i den sceniske virkeligheten, og mellom ulike forventninger til dramafaget. Studien viser at elevene ønsker å pushes faglig, og at de opplever stor mestring når de klarer noe de på forhånd ikke trodde. Samtidig er dette komplekst og avhenger av å finne balansen mellom de mange sammenvevde motsetningene som er i dialektisk samspill. De estetiske læreprosessene i dramafaget kan innebære både muligheter og utfordringer når det gjelder opplevelse av psykisk helse og personlig utvikling.
ENGLISH ABSTRACT
Pushing or cuddling – perspectives on the paradox of the drama space
This article presents findings from a study addressing the A-levels drama program in Norwegian upper secondary education. Drama teachers and former and current drama students from three schools were interviewed. The study demonstrated that the drama space is perceived as a paradox, both as very free and demanding. To investigate which factors may contribute positively and possibly negatively to the students’ experience of mental health in the drama space, we lean on a resource-oriented understanding of health and introduce the concept of the tolerance window from psychology. The paradox of the drama space is examined through three perspectives as fields of tension: between pushing and caring, between the emotional identification and distance in the dramatic as-if reality, and between the incongruent expectations to drama and theatre education. The study illustrates that the students want to be pushed educationally and that they experience great achievement and life efficacy when they manage something they did not believe beforehand. This is, however, complex, and depends on finding a balance between the many entangled interactions. The aesthetic learning processes in the drama space may offer possibilities as well as challenges regarding mental health experience and personal development.