bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efforts To Reduce Rm-1 Refiner Disturbances At Pt Pln (Persero) Ulp Rimo From The Chronic Category With Network Maintenance Based On Inspections Using Thermacam
Authors: Adolf Pratama  , Siti Anisah  , Tarigan Adi Sastra P. 
Published: July 2023

PLN's business is closely related to service to the community. The main problem in carrying out such functions on the part of the distribution is to overcome the interference of the refiner . One of the improvements in the quality of service is by making efforts to reduce the frequency of disturbances and the duration of disturbances. In this journal, the author conducts an analysis on bulusema (RM-1) refiners located at PT PLN (Persero) ULP Rimo, where this refiner is one of the chronic refiners who have a fairly high level of disturbance, so initiatives are needed to improve the reduction of disturbances, in order to improve the quality of service to customers. Based on the results of the author's analysis, the cause of the RM-1 refiner disturbance found was caused by animals, trees that crossed the safe limit, namely a minimum row of 3 meters. One of the efforts to maintain the reliability of the distribution network system from interference is to optimize the implementation of distribution network maintenance, which is prioritized on thermacam inspection to find potential disturbances, replacement of JTM materials based on thermacam inspection and tree planting according to ROW 3 meters implementation of RM-1 feeder network improvement initiatives was carried out in the period from Juneto August 2020 and the Evaluation Results of rm-1 refiner maintenance can be seen in October 2020.
ВІЙСЬКОВО-АДМІНІСТРАТИВНИЙ, ПРАВОВИЙ ЛАД ТА ПОВСЯКДЕННЕ ЖИТТЯ СІЛЬСЬКОГО НАСЕЛЕННЯ ЧЕРНІГІВЩИНИ в 1941–1943 рр.
Authors: Hrytsenko Andriy , Koliienko Anzhelika 
Published: July 2023

Метою розвідки є дослідження особливостей повсякденного життя сільського населення Чернігівщини в 1941–1943 рр. в умовах військово-адміністративного та правового ладу окупаційної влади. Методологічну основу роботи складають загальнонаукові (аналіз, синтез, дедукція, індукція, системний підхід) та спеціально-історичні (історико-генетичний, історико-порівняльний та історико-системний) методи й принципи історизму, періодизації, суб’єктивізму, оптимізації обсягу інформації. Новизна роботи. У статті на основі документальних джерел уперше здійснено аналіз створеного військово-адміністративного та правового ладу. Висновки. Авторами статті звернено увагу, що за час окупації в Чернігівській області повсякденне життя сільського населення значно змінилося. Найвищим проявом його погіршення стало спалення окупантами понад 60 населених пунктів Чернігівщини. Завдяки аналізові історичних джерел та наукових робіт ряду вчених авторами статті також визначено суттєві особливості впливу окупаційного режиму на повсякденне життя сільського населення Чернігівщини, проаналізовано їх основні складники: діяльність польових та місцевих комендатур, розгортання репресивних заходів щодо населення з уведеною системою покарань від штрафів, обмежень до розстрілів та тотальним контролем за життям і діяльністю місцевої людності. Ця каральна політика фактично була помстою окупантів мирним жителям за співпрацю з тутешніми радянськими партизанами. У статті наведено ряд прикладів знищення німецько-нацистськими загарбниками місцевих мирних жителів на теренах Чернігівщини протягом 1941–1943 р. Також визначено, що організований загарбниками окупаційний режим призвів до великих людських втрат серед мирних мешканців сіл та невеличких містечок Чернігівщини, складних умов повсякденного життя через запровадження окупантами жахливого правового становища населення та вивезення людей до Німеччини.
تقييم أسئلة اختبار أعمال السنة في مادة اللغة العربية لدى طلاب الصف الثاني الثانوي بمعهد الإمام مسلم (دراسة تحليلية من جهة سهولة البند والتمييز)
Authors: Kurniawan Rendi , Effendi Zulham , Hasibuan Muhammad Syarif Muda 
Published: July 2023

School is a formal educational institution that provides various opportunities for students to carry out educational activities. With this educational opportunity it is hoped that the growth and development of students can achieve the expected goals. The success or failure of education in achieving its goals after evaluating the graduates produced by the school. If the graduates are in accordance with what has been set in the educational goals, then the educational effort can be said to be successful, and if on the contrary it is considered a failure in this case, it can be understood how important the assessment of learning is in education. Examination or assessment is an important component in education, especially learning assessment, and is important because assessment activities are carried out at least with the aim of knowing (1) the success of learning that has been implemented, (2) student abilities. and understanding of the material being studied, and (3) valuable information. Very useful as feedback for teachers in improving the learning activities that have been carried out. Likewise, if male and female students get high results because they answer all the test questions correctly, then the test questions need to be reviewed so that the test questions match the equation of difficulty percentage and ability percentage, from a height. Because the attributes of a proper evaluation are evaluations that consist of components such as validity, reliability, objectivity, practicality, difficulty level, and test item rating elevation. Therefore, it is necessary for every teacher to carry out a good evaluation process in teaching so that each achieves educational goals and improves educational problems, and the benefits of evaluation in teaching Arabic are available to all elements of the education system. The results obtained from this study are as follows: The researcher found that the form of the midterm exam questions for the Arabic language subject at Imam Muslim Islamic Boarding School was in the form of an essay test and there were ten questions in total. The researcher found a classification of difficulty level for each question, 7 moderate questions, and 3 easy questions, so it can be concluded that all questions are good and feasible to use. The researcher found the classification of the level of differential power that was ideal for each question, one question was not good, one question was limited to adequacy, 4 questions were good, and 4 questions were very good. It can be concluded that all questions are considered good and acceptable so that we can use these questions.
Asymmetric Directional Control of Thermal Emission
Authors: Yu Jianbo , Qin Rui , Ying Yunbin , Qiu Min , Li Qiang 
Published: July 2023

AbstractControl over the directionality of thermal emission plays a fundamental role in efficient heat transport. Although nanophotonic technologies have demonstrated the capability for angular‐selective thermal emission, achieving asymmetric directional thermal emission in reciprocal systems with energy directed to a single output angle remains challenging due to symmetric band dispersion. In this work, a general strategy for achieving asymmetric directional thermal emission in reciprocal systems is presented. With periodic perturbation and broken mirror symmetry, metasurfaces behave as resonant metagratings whose resonances can be diffracted to symmetric output angles with distinct efficiency, allowing for high emissivity toward a single direction. An asymmetric directional thermal emitter is experimentally demonstrated at mid‐infrared wavelengths with high emissivity (ɛ = 0.61) at the observation angle of +30°, and low emissivity (ɛ < 0.3) at other angles. This work highlights the potential for manipulating the directionality of thermal emission, which holds promise for developing ultrathin customized thermal sources and impacts on various thermal‐engineering applications.
MDM2‐Targeting Reassembly Peptide (TRAP) Nanoparticles for p53‐Based Cancer Therapy
Authors: Li Fangzhou , Chen Delin , Sun Qianqian , Wu Jiale , Gan Yaling , Leong Kam W. , Liang Xing‐Jie 
Published: July 2023

AbstractGene mutations and functional inhibition are the major obstacles for p53‐mediated oncotherapy. For p53‐wild‐type tumors, the underlying mechanisms of functional inhibition of p53 during oncogenesis are unknown. The results reveal that the expression of the MDM2 inhibitor ARF is inhibited in p53‐wild‐type tumors, indicating that the restoration of ARF could be a potential oncotherapy strategy for p53‐wild‐type tumors. Therefore, ARF‐mimetic MDM2‐targeting reassembly peptide nanoparticles (MtrapNPs) for p53‐based tumor therapy is developed. The results elucidated that the MtrapNPs respond to and form a nanofiber structure with MDM2. By trapping MDM2, the MtrapNPs stabilize and activate p53 for the inhibition of p53‐wild‐type tumors. In most cases, reactivated mutant p53 is inhibited and degraded by MDM2. In the present study, MtrapNPs are used to load and deliver arsenic trioxide, a p53 mutation rescuer, for p53‐mutated tumor treatment in both orthotopic and metastatic models, and they exhibit significant therapeutic effects. Therefore, the study provides evidence supporting a link between decreased ARF expression and tumor development in patients with p53‐wild‐type tumors. Thus, the MDM2‐trap strategy, which addresses both the inhibition and mutations of p53, is an efficient strategy for the treatment of p53‐mutated tumors.
Interface‐Controlled Biomimetic Intrafibrillar Mineralization of Collagen: Effect of Ca2+/[PO4]3− Concentration Ratio
Authors: Amornkitbamrung Urasawadee , In Yongjae , Lee Jung Heon , Wang Zhen , Oh Sang Ho , Shin Heungsoo , Yoon Dae Sung , Shin Hyunjung 
Published: July 2023

AbstractMineralized fibrils are important building blocks in bone tissue, formed by the hierarchical assembly of collagen molecules and crystalline hydroxyapatite (HAp). The mineralization pathway of HAp is reported as a nonclassical‐crystallization, but the nanoconfined crystallization in collagen fibrils remains poorly understood. The mechanism of intrafibrillar mineralization of collagen‐PDA fibrils in modified‐simulated body fluid (m‐SBF) solution is studied. Collagen‐amorphous calcium phosphate (ACP) fibrils are obtained by assembling collagen‐PDA fibrils with polyaspartic acid (pAsp) as a stabilizer. The ACP undergoes a phase transformation to HAp within the fibrils upon adjusting the phosphate concentration. It is found that the phase transformation of ACP to HAp in collagen fibrils can be accelerated with a 12 h incubation with 1/10 ratio of Ca2+ to [PO4]3−. A lower ratio of 1/1 and 1/5 results in a much slower phase transformation. This finding suggests that an elevated concentration of [PO4]3− is crucial for faster phase transformation. The relationship between the crystallization rate of HAp in the fibrils and the degree of mineralization is found to be linear in all cases, indicating an interface‐controlled process. This gives a better understanding of the mechanism of HAp mineralization in collagen fibrils, providing an effective approach to material design.
Smart and intelligent optical materials for sensing applications
Authors: Singh Ravindra Pratap , Singh Jay 
Published: July 2023

AbstractThis special issue (SI) entitled ‘Smart and intelligent optical materials for sensing applications’, published by Luminescence, Wiley focuses on the recent advancement of smart and intelligent optical materials for the fabrication of sensor technology for use in numerous fields such as pharmaceutical, biomedical, and environmental. Also, detailed highlights of their prospects in the fields, for example, of personalized health care, wearable devices, and plant stress monitoring are given. This SI includes 46 peer‐reviewed articles, of which 15 are reviews written by well established researchers with expertise in the field, and the remaining 31 are research articles from world‐leading scientists.
Suicide‐specific mortality among patients with treatment‐resistant major depressive disorder, major depressive disorder with prior suicidal ideation or suicide attempts, or major depressive disorder alone
Authors: Kern David M. , Canuso Carla M. , Daly Ella , Johnson Jonathan C. , Fu Dong Jing , Doherty Teodora , Blauer‐Peterson Cori , Cepeda M. Soledad 
Published: July 2023

AbstractBackgroundThe impact of treatment‐resistant depression (TRD) or prior suicidal ideation/suicide attempt (SI/SA) on mortality by suicide among patients with major depressive disorder (MDD) is not well known. This retrospective, observational, descriptive cohort study characterized real‐world rates of suicide‐specific mortality among patients with MDD with or without TRD or SI/SA.MethodsAdult patients with MDD among commercially insured and Medicare enrollees in Optum Research Database were included and assigned to three cohorts: those with treatment‐resistant MDD (TRD), those with MDD and SI/SA (MDD+SI/SA), and those with MDD without TRD or SI/SA (MDD alone). Suicide‐specific mortality was obtained from the National Death Index. The effects of demographic characteristics and SI/SA in the year prior to the end of observation on suicide‐specific mortality were assessed.ResultsFor the 139,753 TRD, 85,602 MDD+SI/SA, and 572,098 MDD alone cohort patients, mean age ranged from 55 to 59 years and the majority were female. At baseline, anxiety disorders were present in 53.92%, 44.11%, and 21.72% of patients with TRD, MDD+SI/SA, and MDD alone, respectively. Suicide‐mortality rates in the three cohorts were 0.14/100 person‐years for TRD, 0.27/100 person‐years for MDD+SI/SA, and 0.04/100 person‐years for MDD alone. SI/SA during the year prior to the end of observation, younger age, and male sex were associated with increased suicide risk.ConclusionsPatients with TRD and MDD+SI/SA have a heightened risk of mortality by suicide compared with patients with MDD alone. Suicide rates were higher in patients with recent history versus older or no history of SI/SA, men versus women, and those of young age versus older age.
Comparative evaluation of the clinical and radiographic efficacy of 0.05% zoledronate gel as local drug delivery system in treating intrabony defects in stage III grade B periodontitis patients with and without type‐2 diabetes mellitus—A randomized split‐mouth clinical trial
Authors: Raj Subash Chandra , Mishra Asit Kumar , Mohanty Devapratim , Katti Neelima , Pattnaik Snigdha , Patra Laxmikanta , Pattanaik Abinash 
Published: July 2023

AbstractBackgroundThis 6‐month randomized split‐mouth and placebo‐controlled clinical trial aimed to evaluate the clinical and radiographic efficacy of adjunctive use of 0.05% zoledronate (ZLN) gel as local drug delivery to scaling and root planing (SRP) in stage III, grade B periodontitis patients with and without controlled type‐2 diabetes mellitus (DM).MethodsA total of 120 infrabony sites were divided into two groups: Group‐1 (non‐diabetic periodontitis) and Group‐2 (periodontitis + DM). A total of 60 sites in each group were randomized to receive treatment with SRP + placebo gel (control) or SRP + 0.05% ZLN gel (test). Plaque index (PI), modified sulcus bleeding index (mSBI), pocket probing depth (PPD), and relative attachment levels (RAL) were assessed at baseline, 3 and 6 months, and digital intraoral periapical and cone‐beam computed tomography imaging were used to measure the linear and percentage reduction of intrabony defect depth (DD, DDR%) after 6 months.ResultsGroup‐1 showed significant reduction in PI (0.56 ± 0.15 and 0.52 ± 0.19 from 0.67 ± 0.17), mSBI (0.7 ± 0.60 and 0.47 ± 0.57 from 0.9 ± 0.48), PPD (4.6 ± 0.85 and 3.43 ± 0.63 from 6.5 ± 1.04) and gain in RAL (7.03 ± 0.85 and 5.93 ± 0.69 from 8.9 ± 1.09) in the ZLN‐treated sites than the placebo sites and also from Group‐2 sites after 3 and 6 months, respectively. A significant reduction in DD of 28.79% in Group‐1 and 22.20% in Group‐2 at ZLN sites was seen compared to placebo sites of both groups.ConclusionZLN gel applied subgingivally in infrabony pockets resulted in significant clinical improvements evident by probing depth reduction and gain in attachment levels along with radiographic evidence of more bone fill seen in non‐diabetic patients compared to diabetic periodontitis patients.
Isolation, Structure Elucidation and in Vitro Anticancer Activity of Phytochemical Constituents of Goniothalamus wynaadensis Bedd. and Identification of α‐Tubulin as a Putative Molecular Target by in Silico Study
Authors: Sharma Akanksha , Talimarada Doddabasappa , Dhuri Sundar N. , Sundaram Venkata Narayanan Naranammalpuram , Palanimutu Duraippandi , Holla Harish 
Published: July 2023

AbstractThe phytochemical analysis of ethyl acetate and methanol extract of Goniothalamus wynaadensis Bedd. leaves led to an isolation of eight (1–8) known molecules, among them seven (2–8) isolated for the first time from this species, which includes (+)‐goniothalamin oxide (2), goniodiol‐7‐monoacetate (3), goniodiol‐8‐monoacetate (4), goniodiol (5), (+)‐8‐epi‐9‐deoxygoniopypyrone (6) etc. The phytochemical modification by acetylation of 3 and 4 gave goniodiol diacetate (9) with absolute configuration (6R, 7R, 8R) confirmed by single crystal X‐ray diffraction. Compounds 3–9 were cytotoxic against breast, ovarian, prostate and colon cancer cell lines with IC50<10 μM. Cell cycle analysis and Annexin‐V assay on MDA‐MB‐231 cell using goniodiol‐7‐monoacetate (3) exhibited apoptotic response as well as necrotic response and showed cell proliferation arrest at G2/M phase. An in silico target identification for these molecules was carried out with an α‐tubulin protein target by covalent docking. To gain an in‐depth understanding and identify the stability of these protein‐ligand complexes on thermodynamic energy levels, further assessment of the isolated molecules binding to the Cys‐316 of α‐tubulin was performed based on reaction energetic analysis via DFT studies which hinted the isolated molecules may be α‐tubulin inhibitors similar to Pironetin. Molecular dynamics reiterated the observations.
Changes in Temperature Alter the Toxicity of Polycyclic Aromatic Compounds to American Lobster (Homarus americanus) Larvae
Authors: Philibert Danielle , Marteinson Sarah , de Jourdan Benjamin 
Published: July 2023

Abstract
Polycyclic aromatic compounds (PACs) present in the water column are considered to be one of the primary contaminant groups contributing to the toxicity of a crude oil spill. Because crude oil is a complex mixture composed of thousands of different compounds, oil spill models rely on quantitative structure–activity relationships like the target lipid model to predict the effects of crude oil exposure on aquatic life. These models rely on input provided by single species toxicity studies, which remain insufficient. Although the toxicity of select PACs has been well studied, there is little data available for many, including transformation products such as oxidized hydrocarbons. In addition, the effect of environmental influencing factors such as temperature on PAC toxicity is a wide data gap. In response to these needs, in the present study, Stage I lobster larvae were exposed to six different understudied PACs (naphthalene, fluorenone, methylnaphthalene, phenanthrene, dibenzothiophene, and fluoranthene) at three different relevant temperatures (10, 15, and 20 °C) all within the biological norms for the species during summer when larval releases occur. Lobster larvae were assessed for immobilization as a sublethal effect and mortality following 3, 6, 12, 24, and 48 h of exposure. Higher temperatures increased the rate at which immobilization and mortality were observed for each of the compounds tested and also altered the predicted critical target lipid body burden, incipient median lethal concentration, and elimination rate. Our results demonstrate that temperature has an important influence on PAC toxicity for this species and provides critical data for oil spill modeling. More studies are needed so oil spill models can be appropriately calibrated and to improve their predictive ability. Environ Toxicol Chem 2023;42:2389–2399. © 2023 SETAC
Abstract
Temperature alters the toxicity of polycyclic aromatic compounds to Stage I American lobster larvae, and these temperature-based differences in toxicity are important data inputs for oil spill effects models.
Retirement age and disability status as pathways to later‐life cognitive impairment: Evidence from the Norwegian HUNT Study linked with Norwegian population registers
Authors: Zotcheva Ekaterina , Strand Bjørn Heine , Bowen Catherine E. , Bratsberg Bernt , Jugessur Astanand , Engdahl Bo Lars , Selbæk Geir , Kohler Hans‐Peter , Harris Jennifer R. , Weiss Jordan , Grøtting Maja Weemes , Tom Sarah E. , Krokstad Steinar , Stern Yaakov , Håberg Asta Kristine , Skirbekk Vegard 
Published: July 2023

AbstractBackgroundResearch shows that retirement age is associated with later‐life cognition but has not sufficiently distinguished between retirement pathways. We examined how retirement age was associated with later‐life dementia and mild cognitive impairment (MCI) for people who retired via the disability pathway (received a disability pension prior to old‐age pension eligibility) and those who retired via the standard pathway.MethodsThe study sample comprised 7210 participants from the Norwegian Trøndelag Health Study (HUNT4 70+, 2017–2019) who had worked for at least one year in 1967–2019, worked until age 55+, and retired before HUNT4. Dementia and MCI were clinically assessed in HUNT4 70+ when participants were aged 69–85 years. Historical data on participants' retirement age and pathway were retrieved from population registers. We used multinomial regression to assess the dementia/MCI risk for women and men retiring via the disability pathway, or early (<67 years), on‐time (age 67, old‐age pension eligibility) or late (age 68+) via the standard pathway.ResultsIn our study sample, 9.5% had dementia, 35.3% had MCI, and 28.1% retired via the disability pathway. The disability retirement group had an elevated risk of dementia compared to the on‐time standard retirement group (relative risk ratio [RRR]: 1.64, 95% CI 1.14–2.37 for women, 1.70, 95% CI 1.17–2.48 for men). MCI risk was lower among men who retired late versus on‐time (RRR, 0.76, 95% CI 0.61–0.95).ConclusionDisability retirees should be monitored more closely, and preventive policies should be considered to minimize the dementia risk observed among this group of retirees.
Liver fluke in cattle and sheep: getting ahead of a rapidly adapting parasite
Authors: Colston Matthew , Mearns Rebecca 
Published: July 2023

Background: Liver fluke has a significant impact on the beef, dairy and sheep sectors in terms of disease and production losses, and thus also greenhouse gas emissions. The challenges in managing liver fluke are similar to those for other endoparasites of cattle and sheep, with the threat of resistance to some available actives and a need to focus on the ‘whole farm’ approach. This includes avoiding the challenge where possible and using the right treatment at the right time, by using the available diagnostic tests appropriately. Changes in climate and environmental conditions have led to changes in when snails are active, and therefore when infections are acquired. Treatments based on a set of assumptions as to when immature/adult fluke will be present in cattle and sheep are now likely to lead to unnecessary treatments and incorrect timing of treatment with actives, which may not be effective for the age of fluke in the liver at the time. Timing of treatment will vary on the same farm each year and between farms in the same year. Understanding the life cycle, snail habitats, diagnostic tests and treatments will allow better fluke control in herds and flocks.Aim of the article: This article aims to shift the emphasis from treatments as the main method for control towards other critical control points relating to the mud snail's role as the intermediate host. This will allow an appreciation of risk periods for acquiring, avoiding and detecting infection within the ruminant host.