bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development and validation of a prognostic model incorporating tumor thrombus grading for nonmetastatic clear cell renal cell carcinoma with tumor thrombus: A multicohort study
Authors: Qu Le , Chen Hui , Chen Qi , Ge Silun , Jiang Aimin , Yu Nengwang , Zhou Yulin , Kunc Michał , Zhou Ye , Feng Xiang , Zhai Wei , Wu Zhenjie , He Miaoxia , Li Yaoming , Chen Rui , Han Bo , Zeng Xing , Fu Yao , Ji Changwei , Fan Xiang , Zhang Guangyuan , Zhao Cheng , Jing Taile , Feng Chenchen , Zhao Hongwei , Sun Di , Wang Liang , Tai Sheng , Zhang Cheng , Chen Shaohao , Liu Yixun , Wang Haifeng , Gao Jinli , Gu Yufeng , Miao He , Zhao Tangliang , Yi Xiaoming , Tang Chaopeng , Fu Dian , He Haowei , Rao Qiu , Zhou Wenquan , Xu Ning , Wang Gongxian , Liang Chaozhao , Liu Zhiyu , Xia Dan , Zu Xiongbing , Chen Ming , Guo Hongqian , Qin Weijun , Wang Zhe , Xue Wei , Shi Benkang , Wang Shaogang , Zheng Junhua , Chen Cheng , Zapała Łukasz , Ge Jingping , Wang Linhui 
Published: July 2023

AbstractThere is significant variability with respect to the prognosis of nonmetastatic clear cell renal cell carcinoma (ccRCC) patients with venous tumor thrombus (VTT). By applying multiregion whole‐exome sequencing on normal‐tumor‐thrombus‐metastasis quadruples from 33 ccRCC patients, we showed that metastases were mainly seeded by VTT (81.8%) rather than primary tumors (PTs). A total of 706 nonmetastatic ccRCC patients with VTT from three independent cohorts were included in this study. C‐index analysis revealed that pathological grading of VTT outperformed other indicators in risk assessment (OS: 0.663 versus 0.501–0.610, 0.667 versus 0.544–0.651, and 0.719 versus 0.511–0.700 for Training, China‐Validation, and Poland‐Validation cohorts, respectively). We constructed a risk predicting model, TT‐GPS score, based on four independent variables: VTT height, VTT grading, perinephric fat invasion, and sarcomatoid differentiation in PT. The TT‐GPS score displayed better discriminatory ability (OS, c‐index: 0.706–0.840, AUC: 0.788–0.874; DFS, c‐index: 0.691–0.717, AUC: 0.771–0.789) than previously reported models in risk assessment. In conclusion, we identified for the first‐time pathological grading of VTT as an unheeded prognostic factor. By incorporating VTT grading, the TT‐GPS score is a promising prognostic tool in predicting the survival of nonmetastatic ccRCC patients with VTT.
The evaluation of the effect of metal oxide and ferroelectric ceramic additives on the structural and dielectric properties of epoxy matrix
Authors: Şahin Nazlıcan , Karabul Yaşar , Kılıç Mehmet , Güven Özdemir Zeynep , Esmer Kadir 
Published: July 2023

AbstractThis study focused on examining and comparing the effects of Bi2O3, WO3, and ferroelectric Bi2WO6 ceramic particles on the frequency‐dependent electrical properties of an epoxy matrix, which is known for its good mechanical strength, easy processability, high oxidation resistance, low dielectric loss, and sealing and adhesive properties. The reinforcing particles as well as the composites were examined by Fourier transform infrared analysis, and electrical measurements were carried out at room temperature with an impedance analyzer in the range 20 Hz to 1 MHz. The energy storage performances of the three composite families were compared by limiting the analysis to the real and imaginary components of the complex dielectric constant (ε′ and ε″), the AC conductivity, and the phase angle. When the ε′ and ε″ values of the pure epoxy and the 20% by mass Bi2O3, WO3 and Bi2WO6 doped composites were compared it was observed that WO3 additive causes higher ε′ values than the other additives in the entire frequency region, ignoring the high dielectric loss. However, when ε′ and ε″ were evaluated together, Bi2O3 and Bi2WO6 additives caused lower dielectric loss than WO3 and higher ε′ values than pure epoxy which make these additives more advantageous than WO3 for energy storage applications. In addition to these examinations, frequency‐dependent phase angle evaluation has suggested that 30% Bi2O3 and 20% Bi2WO6 additives can be considered promising for energy storage applications in the high‐frequency region. © 2023 The Authors. Polymer International published by John Wiley & Sons Ltd on behalf of Society of Industrial Chemistry.
Rigid amorphous fraction in isotactic polystyrene induced by cold crystallization: Characterization by differential scanning calorimetry and ellipsometry
Authors: Chen Boran , Feng Boxuan , Wang Tong , Torkelson John M. 
Published: July 2023

AbstractRigid amorphous fraction (RAF) in bulk and thin‐film states of isotactic polystyrene (iPS) was studied as a function of crystalline fraction (CF). The CF increased with isothermal cold crystallization in initially amorphous, melt‐quenched bulk iPS samples. Assessed by differential scanning calorimetry, RAF in bulk iPS increased and then decreased with increasing crystallization time and CF. Specific RAF, that is, RAF/CF, decreased with increasing CF. Using ellipsometry, similar behaviors of RAF and specific RAF as functions of CF were observed in initially amorphous iPS thin films. These results indicate that specific RAF in iPS exhibits a continuous decrease from slightly below 2 at very low CF to ~0.2 at the maximum CF, independent of sample type and characterization method. This trend of decreasing specific RAF is consistent with a progression of crystal perfection during cold crystallization which is associated with lamellae thickening and decoupling between crystalline and amorphous regions. Qualitatively similar behaviors of RAF and specific RAF have been reported in other semi‐crystalline polymers and in our recent studies of syndiotactic polystyrene, indicating that this trend of decreasing specific RAF with increasing CF is general for many semi‐crystalline polymers. Finally, maximum CF is strongly reduced by nanoscale confinement in thin iPS films.
Transmission of knowledge and social learning for disaster risk reduction and building resilience: A Delphi study
Authors: Ross Helen , Haque C. Emdad , Berkes Fikret 
Published: July 2023

AbstractThe UN Sendai Framework recognized the need for making our communities safer and more resilient to disasters by shifting policy goals from “managing disasters” to disaster risk reduction (DRR) and building resilience. For DRR and building community resilience to disaster shocks, this study posits that social learning, a process of mutual development and sharing knowledge through iterative reflections on experience, is key to changing the conventional linear logic‐based, reactive framework into one based on learning‐by‐doing (adaptive management). Toward this end, a three‐round Policy Delphi process was pursued with a combination of 18 international DRR and SES (social–ecological systems) resilience scholars, practitioners, and public officials. Weak policy frameworks; operational, cultural and educational/training silos; and domination of technical knowledge were identified as major challenges in knowledge and learning transmission. Balancing technical knowledge with social science, and working toward transdisciplinary approaches and transformative practices should, therefore, be nurtured.
Selective Electrochemical Benzylic C(sp3)−H Oxidations in Fluoroalcohols
Authors: Shen Haiwei , Yang Bo , Lin Jiusheng , Zheng Mingyue , Jiang Hualiang 
Published: July 2023

AbstractA site‐selective electrochemical benzylic C(sp3)−H oxidation reaction of aryl alkanes has been reported for synthesis of the desired products. This method significantly expands the scope and enhances the selectivity of aryl aldehydes and fluorinated ethers. Electricity is used as a sustainable oxidant and promote H2 evolution. This protocol is eco‐friendly and easy to handle as it uses a simple undivided cell in mild conditions without employing any catalyst and oxidant.
Semiclassical approach to form factors in the sinh-Gordon model
Authors: Lashkevich Michael , Lisovyy Oleg , Ushakova Tatiana 
Published: July 2023

Abstract
Form factors in the sinh-Gordon model are studied semiclassically for small values of the parameter b ~ ħ1/2 in the background of a radial classical solution, which describes a heavy exponential operator placed at the origin. For this purpose we use a generalization of the radial quantization scheme, well known for a massless boson field. We introduce and study new special functions which generalize the Bessel functions and have a nice interpretation in the Tracy-Widom theory of the Fredholm determinant solutions of the classical sinh-Gordon model. Form factors of the exponential operators in the leading order are completely determined by the classical solutions, while form factors of the descendant operators contain quantum corrections even in this approximation. The construction of descendant operators in two chiralities requires renormalizations similar to those encountered in the conformal perturbation theory.
Pudexacianinium (ASP5354) chloride for ureter visualization in participants undergoing laparoscopic, minimally invasive colorectal surgery
Authors: Albert Matthew , Delgado-Herrera Leticia , Paruch Jennifer , Gerritsen-van Schieveen Pauline , Kishimoto Tomoyoshi , Takusagawa Shin , Cai Na , Fengler John , Raizer Jeffrey 
Published: July 2023

Abstract
Background
Intraoperative ureteral injury, a serious complication of abdominopelvic surgeries, can be avoided through ureter visualization. Near-infrared fluorescence imaging offers real-time anatomical visualization of ureters during surgery. Pudexacianinium (ASP5354) chloride is an indocyanine green derivative under investigation for intraoperative ureter visualization during colorectal or gynecologic surgery in adult and pediatric patients.

Methods
In this phase 2 study (NCT04238481), adults undergoing laparoscopic colorectal surgery were randomized to receive one intravenous dose of pudexacianinium 0.3 mg, 1.0 mg, or 3.0 mg. The primary endpoint was successful intraoperative ureter visualization, defined as observation of ureter fluorescence 30 min after pudexacianinium administration and at end of surgery. Safety and pharmacokinetics were also assessed.

Results
Participants received pudexacianinium 0.3 mg (n = 3), 1.0 mg (n = 6), or 3.0 mg (n = 3). Most participants were female (n = 10; 83.3%); median age was 54 years (range 24–69) and median BMI was 29.3 kg/m2 (range 18.7–38.1). Successful intraoperative ureter visualization occurred in 2/3, 5/6, and 3/3 participants who received pudexacianinium 0.3 mg, 1.0 mg, or 3.0 mg, respectively. Median intensity values per surgeon assessment were 1 (mild) with the 0.3-mg dose, 2 (moderate) with the 1.0-mg dose, and 3 (strong) with the 3.0-mg dose. A correlation was observed between qualitative (surgeon’s recognition/identification of the ureter during surgery) and quantitative (video recordings of the surgeries after study completion) assessment of fluorescence intensity. Two participants experienced serious adverse events, none of which were drug-related toxicities. One adverse event (grade 1 proteinuria) was related to pudexacianinium. Plasma pudexacianinium concentrations were dose-dependent and the mean (± SD) percent excreted into urine during surgery was 22.3% ± 8.0% (0.3-mg dose), 15.6% ± 10.0% (1.0-mg dose), and 39.5% ± 12.4% (3.0-mg dose).

Conclusions
In this study, 1.0 and 3.0 mg pudexacianinium provided ureteral visualization for the duration of minimally invasive, laparoscopic colorectal procedures and was safe and well tolerated.
Zusammenhänge etablierter HRV-Parameter mit selten verwendeten Parametern in Zeiträumen unterschiedlicher Dauer
Authors: Rother Janosch Jens , Darius Sabine , Thielmann Beatrice , Sammito Stefan , Böckelmann Irina 
Published: July 2023

ZusammenfassungDie Analyse der Herzratenvariabilität (HRV) wird immer häufiger in verschiedenen arbeitswissenschaftlichen Disziplinen, aber auch in klinischen Forschungsfeldern zur Einschätzung der Aktivität des autonomen Nervensystems genutzt, um Rückschlüsse auf Belastung und Allgemeinzustand von Proband*innen und Patient*innen zu ziehen. Problematisch ist die große Fülle an verschiedensten HRV-Parametern, die zwar alle auf den ersten Blick die HRV analysieren, im Detail aber häufig durchaus ganz unterschiedliche Aspekte des komplexen autonomen Nervensystems widerspiegeln. Diese Querschnittsstudie vergleicht verschiedene, häufig genutzte HRV-Parameter mit selten verwendeten Parametern in drei unterschiedlichen Zeiträumen von 24 h, 6 h nachts und 1 h vormittags miteinander. Hierzu trugen 289 Probandinnen ein 24-h-EKG-Gerät zur Messung der Abstände der Herzaktionen. Die Auswertung der Daten demonstrierte, dass die betrachteten Parameter sich in unterschiedlich langen Messzeiträumen verschieden verhielten. Die Betrachtung einiger nur selten verwendeter HRV-Parameter zeigte, dass diese mit den etablierten Parametern zwar korrelierten, aber durchaus unterschiedlich in verschiedenen Aufnahmezeiträumen und -settings reagierten und somit ein großes Potenzial für weitere Untersuchungen haben.
From Videogames to Teaching — Different Camera Perspectives in an Interactive Synchronous Online Tutorial
Authors: Boten David Niklas , Daum Nils , Schutz Thomas , Spethmann Sebastian 
Published: July 2023

AbstractThe global COVID-19 pandemic has required clinical skills training to be transferred to an online format. An interactive synchronous online tutorial with different camera perspectives was developed. In a survey, 79% of the students preferred the first-person perspective, which allowed students to view the abdominal examination through the examiner’s eyes.
Image inpainting via progressive decoder and gradient guidance
Authors: Hou Shuang , Dong Xiucheng , Yang Chencheng , Wang Chao , Guo Hongda , Zhang Fan 
Published: July 2023

AbstractVery recently, with the widespread research of deep learning, its achievements are increasingly evident in image inpainting tasks. However, many existing multi-stage methods fail to effectively inpainting the larger missing areas, their common drawback is that the result of each stage is easily misguided by the wrong content generated in the previous stage. To solve this issue, in this paper, a novel one-stage generative adversarial network based on the progressive decoding architecture and gradient guidance. Firstly, gradient priors are extracted at the encoder stage to be passed to the decoding branch, and multiscale attention fusion group is used to help the network understand the image features. Secondly, multiple parallel decoding branches fill and refine the missing regions by top-down passing the reconstructed priors. This progressively guided repair avoids the detrimental effects of inappropriate priors. The joint guidance of features and gradient priors helps the restoration results contain the correct structure and rich details. And the progressive guidance is achieved by our fusion strategy, combining reimage convolution and design channel coordinate attention to fuse and reweight the features of different branches. Finally, we use the multiscale fusion to merge the feature maps at different scales reconstructed by the last decoding branch and map them to the image space, which further improves the semantic plausibility of the restoration results. Experiments on multiple datasets show that the qualitative and quantitative results of our computationally efficient model are competitive with those of state-of-the-art methods.
Relationships between religion, moral foundations, and environmentalism in young adult Catholics
Authors: Skalski-Bednarz Sebastian Binyamin , Konaszewski Karol , Toussaint Loren L. , Kwiatkowska Anna , Surzykiewicz Janusz 
Published: July 2023

AbstractThe purpose of this study was to examine the mediating role of moral foundations in the relationship between religion and environmentalism. The online survey data was collected from 616 young adult Catholics from Poland aged 19–25, who are likely to be affected by climate change more than any other generation before them. Regression analysis showed that the relationship between religion and environmentalism can be predicted by the opposing paths of spirituality (positively) and religious fundamentalism (negatively). Analysis of multiple mediator models showed that the relationship between religion and climate care can be mediated by complex moral profiles that can influence each other and jointly contribute to the development of environmentalism. Analysis of specific indirect effects showed that care/harm and fairness/cheating play a special role in promoting climate care. The results suggest that religious attitudes, along with moral values, may play a significant role in solving climate problems.
The Envy of Asinius Gallus
Authors: Satterfield Susan 
Published: July 2023

AbstractThis paper explores the career and fall of Gaius Asinius Gallus. It argues that Gallus supported Tiberius and worked to increase the Senate's dignity, and that he mediated between the Senate and emperor. It explains Gallus’ downfall in light of his career: he resented Sejanus as a threat to the Senate, and he envied his role as Tiberius’ adiutor. His efforts to honour the prefect in 30 CE were not enough to save him.
Are You a Vegan or Are You an Extremist?
Authors: Francione Gary L. 
Published: July 2023

AbstractOur conventional wisdom about animal ethics, as embodied in the animal welfare position, is that animals are not things to whom we can have no moral obligations. Animals who are sentient, or subjectively aware, have a morally significant interest in not suffering. But, because they are not self-aware, they do not as an empirical matter have an interest in continuing to live. So we may use and kill animals as long as we do so ‘humanely’ and do not impose ‘unnecessary’ suffering on them. There are at least two serious problems with our conventional wisdom in this regard. First, because animals are chattel property, we undervalue or ignore their interests in not suffering. Second, we cannot justify the view that animals who are sentient do not have a morally significant interest in continuing to live. If animals are not things and matter morally, our institutionalized exploitation of them cannot be justified, and veganism is a moral imperative.
Extension of Large Fire Emissions From Summer to Autumn and Its Drivers in the Western US
Authors: Wang S. S.‐C. , Leung L. R. , Qian Y. 
Published: July 2023

AbstractBurned areas in the western US have increased ten‐fold since 1980s, which are attributable to multiple factors, including increasing heat, changing precipitation patterns, and extended drought. To better understand how these factors contribute to large fire emissions (gridded monthly fire emissions >95th percentile of all the fire emissions in the western US; 0.009 Gg/month), we build a machine learning model to predict fire emissions (PM2.5) over the western US at 0.25° resolution, interpreted using explainable artificial intelligence (XAI). From the predictor contributions derived from XAI, we conduct k‐means clustering analysis to identify four clusters of predictor variables representing different drivers of large fire emissions. The four clusters feature the contributions of fuel load (Cluster 1) and different levels of dryness (Cluster 2–4), controlled by fuel moisture, drought condition, and fire‐favorable large‐scale meteorological patterns featuring high temperature, high pressure, and low relative humidity. In the past two decades, large fire emissions peak in summer. However, large fire emissions increased significantly in September and October in 2010–2020 relative to 2000–2009, extending the peak large fire emissions from summer to autumn. The larger enhancements of large fire emissions during autumn compared to summer are contributed by decreased fuel moisture, along with more frequent concurrent fire‐favorable large‐scale meteorological patterns and drought. These results highlight fuel drying as a common driver supported by multiple drivers, such as warmer temperature and more frequent synoptic patterns favorable for fires, in increasing the autumn risk of large fire emissions across the western US.
Tectonics, Base‐Level Fluctuations, and Climate Impact on the Eocene to Present‐Day Erosional Pattern of the Arabia‐Eurasia Collision Zone (NNW Iranian Plateau and West Alborz Mountains)
Authors: Kaveh‐Firouz Amaneh , Burg Jean‐Pierre , Haghipour Negar , Mandal Sanjay Kumar , Christl Marcus , Mohammadi Ali 
Published: July 2023

AbstractThe NNW Iranian Plateau and west Alborz within the Arabia‐Eurasia collision zone are characterized by three main tectono‐stratigraphic zones, crosscut by the Qezel‐Owzan River (QOR) Basin. The interplay between present‐day deformation and climate, which control the landscape evolution of the region, is still poorly constrained. We addressed this gap by measuring millennial‐scale erosion rates from 10Be‐concentration in the QOR sands along with topographic/climatic metrics analyses. Results reveal low erosion rates in the Plateau and relatively high in the west Alborz. The regional consistency of topographic parameters with geomorphology suggests that they control sediment fluxes in the Plateau, while the surface uplift, active thrust‐faulting, and shallow crustal seismicity in the west Alborz are the main controlling factors. Climate has a secondary role on erosion rates. Furthermore, we calculated exhumation rates from published thermochronometric AFT/AHe ages to determine their relationship with 10Be short‐term data. Results imply that the exhumation rates increased slightly in the Plateau and west Alborz from ∼26 to ∼10 Ma, simultaneous with hard collision processes between the Arabia‐Eurasia. This trend accelerated from ∼10 to ∼2.8 Ma due to the isolation of the Caspian Sea and extreme base‐level fall. From ∼2.8 to ∼2 Ma, base‐level rise occurred under climate influence, and erosion rates decreased. Millennial‐scale data show the erosion rate decreased from ∼2 Ma to the Present‐day, which is attributed to the change in deformation style and fault kinematics from fold/thrusting to mainly strike‐slip faulting. The significantly lower erosion rates in the Plateau compared to west Alborz suggest a relatively stable plateau surface.
Flexible multichannel electrodes for acute recording in nonhuman primates
Authors: Wang Yang , Wang Qifan , Zheng Ruichen , Xu Xinxiu , Yang Xinze , Gui Qiang , Yang Xiaowei , Wang Yijun , Cui He , Pei Weihua 
Published: July 2023

AbstractFlexible electrodes have demonstrated better biocompatibility than rigid electrodes in relieving tissue encapsulation and long-term recording. Nonhuman primates are closer to humans in their brains’ structural and functional properties, thus making them more suitable than rodents as animal models for potential clinical usage. However, the application of flexible electrodes on nonhuman primates has rarely been reported. In the present study, a flexible multichannel electrode array for nonhuman primates was developed and implemented for extracellular recording in behaving monkeys. To minimize the window of durotomy for reducing possible risks, a guide-tube-compatible implantation solution was designed to deliver the flexible electrodes through the dura into the cortex. The proposed structure for inserting flexible electrodes was characterized ex vivo and validated in vivo. Furthermore, acute recording of multichannel flexible electrodes for the primates was performed. The results showed that the flexible electrodes and implantation method used in this study meet the needs of extracellular recording in nonhuman primates. Task-related neuronal activities with a high signal-to-noise ratio of spikes demonstrated that our whole device is currently a minimally invasive and clinically viable approach for extracellular recording.