bluuebunny/crossref_metadata_2025_split huggingface dataset:
Alterations in Neuroendocrine Axes in Brain-Dead Patients
Authors: Akbaş Türkay , Öztürk Ayhan 
Published: May 2023

Abstract
Purpose: To identify changes in anterior pituitary gland hormone levels in brain-dead patients, and alterations in free triiodothyronine (fT3), free thyroxine, cortisol, testosterone, and estradiol levels.
Methods: Ten postmenopausal women and 22 men with brain death (BD) were included. The first blood sample for determining hormones (pre-BD) was collected when the clinician observed the first symptoms of BD. The second blood sample (BD day) was drawn after BD certification.
Results: Female patients exhibited lower follicle-stimulating hormone and prolactin levels pre-BD and luteinizing hormone, follicle-stimulating hormone and prolactin levels on BD day than the age-matched controls. Male patients’ sex hormone levels were similar to those of the age-matched controls, except for testosterone levels, which were low in both consecutive measurements. All gonadotropins and prolactin levels were above the tests’ lower detection limits (LDLs), except for one male patient with gonadotropin levels below the LDLs of the tests. Estradiol levels in both sexes ranged from normal to elevated. FT3 levels were significantly decreased in the two measurements. Thyroid-stimulating hormone (TSH) levels were low in eight patients, and all low TSH levels were above the test’s LDL. The remaining patients had normal or elevated TSH levels. The median adrenocorticotropic hormone (ACTH) and cortisol levels were within normal limits. All cortisol and ACTH levels were above the tests’ LDLs, except for one patient with ACTH levels below the LDL in both measurements.
Conclusion: This study supports that the anterior pituitary gland continues functioning in the brain-dead state.
Prevalence and Associated factors of Anxiety symptoms among front-line Health care workers in Tigrai region quarantine and Treatment centers, Southern Ethiopia 2020; Cross-sectional study
Authors: Niguse Gebrezabher , Abreha Zewde , Tsegay Abreha , Rejeu Mehammedseid , Siyum Desta 
Published: May 2023

Abstract
Background Corona virus disease (COVID-19) has caused universal psychological impact around the globe. Healthcare workers are among the many groups of people who are in the frontline and facing a risk of direct exposure to the virus. The purpose of the study was to assess anxiety symptoms and associated factors among health care workers managing COVID-19 in Tigray region quarantine and treatment centers.Methods A Cross-sectional study was conducted on 155 study participants in Tigrai region quarantine and Treatment centers from June 2020 to September 2020. Data were collected using online survey. Binary logistic regression analysis was conducted to identify factors that affect anxiety symptoms. Statistical significance was declared using a p-value < 0.05 and 95% of confidence interval (CI) for an adjusted odds ratio (AOR).Results The study found that the prevalence rate of anxiety symptoms among health care workers was 23.9%. This study also indicated that being gender AOR 2.310:95%CI [1.301–4.641], history of anxiety AOR 0.008:95%CI [0.000-0.144],institutional support AOR 3.244:95%CI [1.930–5.438] were significant predictors of anxiety symptoms among health care workers.Conclusion The prevalence of anxiety symptoms among HCWs in Tigray region during the pandemic is comparable with other countries.
Impact of a training strategy on improving compliance of hand hygiene and gloving during the placement of a short peripheral venous catheter: the multicentre study CleanHand4
Authors: FARIZON Mathilde , SANTOS Sandra DOS , RICHARD Lucas , PETITEAU Agnès , VALENTIN Anne-Sophie , MEE-MARQUET Nathalie VAN DER 
Published: May 2023

Abstract
Background. Patients who have short peripheral venous catheters (PVC) face an elevated risk of developing bloodstream infections. Preventing catheter-related infections relies on implementing multiple measures, including practicing proper hand hygiene (HH) during catheter placement.Methods. We conducted a four-part study : (1) an evaluation of HH practices through direct observation of PVC placements, coupled with the study of the microbial flora of the HCWs fingers just before the placement; (2) the development of an educational tool based on the collected observational and microbiological data; (3) the training to the HCWs observed during the first part, using this tool; and (4) the subsequent observation of the trained HCWs to measure the impact of the training on practice improvement.Results. Compliant HH was observed in 23.5% of the 647 HCWs observed during PVC placement before training. The microbiological study revealed fewer pathogens on the fingertips of the HCWs practicing compliant HH compared other HCWs (2.6 vs 11,7%; p = 0.003). The comparison of practices before and after training, assessed amng 180 HCWs, showed an increase in the proportion of HCWs performing compliant HH (63.2 vs 25.0%; p < 0.001).Conclusions. Training HCWs using our educational tool, which combines reminders of best practices and risk factors associated with PVC-related infections, engaging HCWs (presentation of practice evaluation), identifying professionals deviating from best practices (simulation videos), and objectively assessing fingertip contamination (microbiological study), significantly improved compliance with HH gestures and glove usage. We encourage infection control teams to utilize this tool to raise awareness among HCWs responsible for PVC placement about the risk of infection associated inadequate hand hygiene.
A randomized phase II study of full dose gemcitabine versus reduced dose gemcitabine and nab-paclitaxel in vulnerable patients with non-resectable pancreatic cancer (DPCG-01)
Authors: Rasmussen Louise Skau , Winther Stine B , Chen Inna M , Weber Britta , Ventzel Lise , Liposits Gabor , Johansen Julia Sidenius , Detlefsen Sönke , Egendal Ida , Shim Susy , Christensen Signe , Pfeiffer Per , Ladekarl Morten 
Published: May 2023

Abstract
Background
According to current evidence, the best treatment for fit patients with non-resectable pancreatic cancer (PC) is combination chemotherapy, whereas frail patients are recommended gemcitabine (Gem) monotherapy. Randomized controlled trials in colorectal cancer and a post-hoc analysis of gemcitabine and nab-paclitaxel (GemNab) in PC suggest, however, that reduced dose of combination chemotherapy may be feasible and more efficient compared to monotherapy in frail patients. The aim of this study is to investigate whether reduced dose GemNab is superior to full dose Gem in patients with resectable PC, who are not candidates for full dose combination chemotherapy in first line.
Methods
The Danish Pancreas Cancer Group (DPCG)-01 trial is a national multicenter prospective randomized phase II trial. A total of 100 patients in ECOG performance status 0-2 with non-resectable PC, not candidate for full dose combination chemotherapy in first line, but eligible for full dose Gem, will be included. Patients are randomized 1:1 to either full dose Gem or GemNab in 80% of recommended dose.
The primary endpoint is progression-free survival. Secondary endpoints are overall survival, overall response rate, quality of life, toxicity and rate of hospitalizations during treatment. The correlation between blood inflammatory markers, including YKL-40 and IL-6, circulating tumor DNA, and tissue biomarkers of resistance to chemotherapy and outcome will be explored. Finally, the study will include measures of frailty (G8, modified G8, and chair-stand-test) to assess whether scoring would enable a personalized allocation to different treatments or indicates a possibility for interventions.
Discussion
Single-drug treatment with Gem has for frail patients with non-resectable PC been the main treatment option for more than thirty years, but the impact on outcome is modest. If improved results and sustained tolerability with reduced dose combination chemotherapy can be shown, this could change the future practice for this increasing group of patients.
Trial registration
ClinicalTrials.gov Identifier: NCT05841420.
Secondary Identifying No: N-20210068.
EudraCT No: 2021-005067-52.
Protocol version: 1.5, 16-MAY-2023.
Pink esthetic score with Autogenous Dentin Chips versus Xenograft with Conventional Immediate Implantation in Thin Buccal Bone:(Randomized Controlled clinical trial)
Authors: Hamada cherine , reda ahmed , shoeib mona 
Published: May 2023

Abstract
Objectives: soft tissue in the esthetic zone for an immediate implant Is considered challenging. This study aimed to evaluate soft tissue aesthetics around immediate dental implants with dentin chips and xenograft in thin buccal bone.
Materials and Methods:non-restorable teeth (n=16) were recruited in this study for immediate implant placement with augmentation using dentin chips and xenografts. Patients were randomly assigned into two equal groups (n=8). Pink aesthetic scores are recorded on loading, at 6 months & after 1 year of implant insertion according to Vanlıoğlu. ; buccal, crestal bone resorption was measured using CBCT at months & 1 year and implant stability was measured using osstel twice, and pain was recorded according to Breivik.
Results: Both groups showed better PES after 6 months and 1 year P-value = 0.343; P-value = 0.199; the nearly same level of crestal bone & The buccal bone at 6 months & 1 year; implant stability is better at 6 months and one year P-value = 0.514; P-value = 0.340 and reduction in the post-operative pain within 1 week following implant placement but with statistically a significant difference between both groups.
Conclusions:
The use of autogenous dentin chips proved to be a valid alternative to bone grafting materials to fill the jumping gap in conjunction with immediate implants in the aesthetic zone.
PES, the overall difference between the control and the intervention groups showed no statistical significance.
Clinical relevance :
Autogenous dentin chips may be a good alternative to xenograft with a cost-effectiveness advantage
New characterizations of the ring of the split-complex numbers and the field C of complex numbers and their comparative analyses
Authors: Yadeta Hailu Bikila 
Published: May 2023

Abstract
In this paper, we give a new characterization of the split-complex numbers as a vector space LC2 = {xI + yE : x, y ∈ R, E 2 = I} of operators, where I is the identity operator and E is the unit shift operator that are operating on the space P2 of all real-valued 2-periodic functions. We also characterize the field of the complex number C = {x + yi : x, y ∈ R, i 2 = −1} as the space of linear operators of the form {xI +yE, E 2 = −I}, where I is the identity operator and E the unit shift operator that are regarded as operating on the vector space AP2 of all real-valued 2-antiperiodic functions. In an analogy to the polar form of complex numbers, we form the hyperbolic form of some subset H of the elements of LC2. We study some properties of the elements of LC2, the trace, the determinant, invertibility conditions, and others. We study some elementary functions defined on subsets of LC2 as compared and contrasted with the usual complex functions. We study properties like continuity, differentiability and define the holomorphic condition of LC2 functions in a different sense than complex functions. We establish the line integrals of the vector-valued functions in LC2 and compare them against the well known results for complex functions of a complex variable.
MSC2020: Primary 30A99, 47B38, 47B39, 47B92, 39A23
MSC2020: Secondary 16S90
Fabrication of robust homogeneous braid reinforced CA hollow fiber membranes with enhanced hydrophilicity
Authors: Zhao Wei , jin Xin , Sun Guangwu , Chen Kaikai , Ling Haoyang , Fan Zuwei , Xiao Changfa 
Published: May 2023

Abstract
Cellulose acetate (CA) membrane is usually utilized in wastewater treatment and biomedical process due to its good biocompatibility and easy processing but low flux and poor anti-fouling. The hydrophilicity and anti-fouling property of membrane could be improved through the doping of functional nanoparticles. Herein, the robust homogeneous braid reinforced (HBR) CA hollow fiber membranes with GO doping were fabricated by the continuous skin-core spinning method. The content of GO exhibited noticeable effects on the structure and property of HBR CA hollow fiber membranes. On the one hand, the neatly arranged finger-like pore structure and good permeability could be designed. On the other hand, the high protein rejection and anti-fouling property were obtained. For example, the pure water flux and BSA rejection could be obviously improved from 115.7 L·m-2·h-1 to 201.4 L·m-2·h-1, 97.2% to 99.5% respectively. The optimal GO content was 0.1 wt.% according to the assessment of flux decline coefficient, flux recovery rate and BSA rejection. Moreover, the HBR structure provided favorable interface bonding strength and excellent mechanical strength, which was suitable for the high pressure backwash and aeration process in filtration system. In a word, the HBR CA hollow fiber membrane with good hydrophilicity and anti-fouling property showed potential applications for wastewater treatment and biomedical process.
Low phase noise of concurrent dual-band oscillator with negative resistance
Authors: Afkari Ehsan , Ahmadpour Behrouz , Allahverdi Majid , Bemani Mohammad 
Published: May 2023

Abstract
In this paper, we study the design of dual-band concurrent low phase noise oscillator with negative resistance structure. First, for each frequency band, a single-band negative resistance oscillator is designed separately. A suitable dual-band matching circuit has been used to dual-band these two oscillators so that we can oscillate at both frequencies simultaneously at last oscillator operates concurrently at 2.4GHz and 5.2GHz frequencies separately. Synchronization improves the performance of the oscillator, increases the data transfer speed and reduces the dimensions of the oscillator and also the design method of the oscillator with negative resistance is a simple and low cost method in designing the oscillator. One of the challenges in designing an oscillator is the oscillator's phase noise, the oscillator should ideally have low phase noise. In this oscillator, the simulated phase noise values, at 10MHz offset for the frequencies of 2.4GHz and 5.2GHz are -137.28dBc/Hz and -140.388dBc/Hz,respectively and the amount of output powers are 3.991dBm and 4.583dBm.
Study on the diffusion law of dynamic water grouting in fracture with slurry-rock stress coupling effect
Authors: Liu Yang , Wang Yingchao , Sui Wanghua , Han Lijun 
Published: May 2023

Abstract
Water inrush disasters in geotechnical engineering are mainly caused by seepage in fractures, and curtain grouting is the most common method to block water flow. To ensure the effectiveness of the water blocking curtain, it is necessary to study the diffusion pattern of the slurry. In this study, by means of laboratory experiments and theoretical deductions, the grout diffusion morphology in fractures with the slurry-rock stress coupling effect is revealed, and the corresponding theoretical model is established. First, based on the failure of a water curtain in a hydropower project in Yunnan Province, a four-level four-factor orthogonal table was set up, grouting experiments were conducted by using the self-developed fracture grouting device, and the relationship between the main influencing factors and fracture deformation and grout diffusion distance was revealed by variance analysis. Then, based on the Bingham fluid constitutive model, the fracture deformation equation and the grouting model with flowing water, a new fracture grouting model considering the coupling effect of slurry-rock stress was established. Finally, based on the calculations and experiments, the morphology of slurry diffusion is described, thereby proving the validity of the new model.
FOF: A Fine-Grained Object Detection and Feature Extraction end-to-end Network
Authors: Shen Wenzhong , Chen JinPeng , Shao Jie 
Published: May 2023

Abstract
Currently, widely-used object detection can predict targets present in the training set. However, in fine-grained object detection tasks, such as commodity detection, the introduction of a new target class requires retraining the model, which significantly reduces the flexibility of the algorithm in applications. In response to this problem, we propose an end-to-end fine-grained object detection and feature extraction network(FOF). To detect and identify objects beyond the target category of the training set, the category output in the network Head is removed and replaced with a 128-dimensional feature vector. We used the ArcFace loss function to improve feature classification during training. Since there is no category output, an improved Non-Maximum Suppression(NMS) algorithm, Non-Maximum Suppression-Feature Similarity(NMS-FS), is proposed to distinguish same class and dissimilar class prediction boxes by feature similarity. During the inference, FOF outputs prediction boxes and feature vectors, and matches them with the feature vectors in the feature gallery to determine the detected object category and complete object detection and recognition. Experimental results indicate that FOF achieved high accuracy in both the MS COCO dataset and a large-scale and fine-grained Retail Product Checkout dataset(RPC). In addition, the method exhibits a low Equal Error Rate(EER) when identifying new categories, achieving the objective of detecting and identifying new categories without the need to retrain the model.
The first-ever clinical classification of metastatic spinal malignancies serves as a vital reference to surgical management:a retrospective case-control study
Authors: Bai Junjun , Li Jian , Lv Jia , Yang Wangzhe , Wang Yushan , Lv Zhi , Feng Yi 
Published: May 2023

Abstract
Background: It is commonly accepted that Surgical treatment is an essential component of the comprehensive treatment of metastatic spinal malignancies. However, Up until now, the clinical classification of metastatic spinal malignancies has not been well-structured.
Methods: After IRB approval, 86 patients with metastatic spinal malignancies who underwent therapy at the Second Hospital of Shanxi Medical University between January 2014 and March 2020 were adopted. According to the vascular distribution, stability of vertebrae and the degree of nerve compression, osteolytic metastatic spinal tumors can be classified into five types. 20 of them who did not receive segmental arterial embolization was set as a control group. The standard group included 24 patients who received segmental arterial embolization on both sides of the diseased vertebrae. 42 patients were included in the intervention group after receiving responsible arterial embolization. Surgical intervention was performed within 24 hours following an embolization.
Results: In comparison with the control and standard groups, the intervention group presented unique advantages in terms of bleeding volume (p＜0.001), operating time (p＜0.001), and local recurrence rate within 12 months (p＜0.006).
Conclusion: The promising surgical intervention strategies can be developed according to the new clinical classification of metastatic spinal malignancies.
Exosomes from Adipose-derived stem cells overexpressing microRNA-671-3p promote fat graft angiogenesis and adipogenic differentiation
Authors: Hao Xiaoyan , Guo Yuan , Yu Xueyuan , He Lin , He Youcheng , Shu Maoguo 
Published: May 2023

Abstract

Exosomes from Adipose-derived stem cells (ADSCs) have been demonstrated to benefit angiogenesis, wound healing and fat grafting. Small noncoding RNAs such as microRNA (miRNA) and circular RNA play critical role mediating the function of ADSC-derived exosomes. However, the underlying mechanisms have not been fully elucidated. In this study, we investigated the function and mechanism of ADSC-derived exosome promoting fat graft angiogenesis and adipogenic differentiation. Exosomes from ADSCs were isolated and identified while treatment with ADSC-derived exosomes enhanced fat graft angiogenesis and adipogenic differentiation in mouse fat graft implantation model. We found that ADSC-derived exosome overexpressed miR-671-3p and promoted human umbilical vein endothelial cell (HUVEC) proliferation, migration and invasion. Bioinformatics analysis and luciferase reporter assay validated that TMEM127 was a direct target of miR-671-3p. Rescue experiments demonstrated that overexpression of TMEM127 partially antagonized the function of ADSC-derived exosome in vitro, suppressing HUVEC cell proliferation, migration and invasion. Moreover, overexpression of TMEM127 abrogated the function of ADSC-derived exosome on fat graft angiogenesis and adipogenic differentiation. Taken together, our findings demonstrate that exosomes from ADSC overexpressing miR-671-3p promote fat graft angiogenesis and adipogenic differentiation.
The Relationship Between Work-Related Factors, Risky Behaviors, and Major Accidents Among Motorcycle Food Delivery Riders (MFDR) in Thailand
Authors: Kwangsukstith Siriaran , Surawattanasakul Vithawat , Mahakkanukrauh Chollada , Panumasvivat Jinjuta , Sirikul Wachiranun , Kitro Amornphat 
Published: May 2023

Abstract

Motorcycle food delivery riders (MFDR) are more susceptible to traffic collisions when compared to regular motorcyclists. Their safety is a major concern in many developing countries, especially Thailand, which has the highest rate of motorcyclist fatalities in the world. This cross-sectional study aimed to identify the prevalence of accidents, hospitalization, involvement in risky behaviors, and concerning problems among MFDR and determine factors associated with accidents. The data were collected from 709 MFDR in Chiang Mai, Thailand. The prevalence of any accidents among MFDR in the past six months was 18.9% which can be categorized into 4.9% minor injuries, 2.4% hospitalized major injuries, and 11.6% non-hospitalized major injuries. 84.3% of them engaged in at least one risky behavior and 5.8% of them engaged in ten or more risky behaviors. The most frequent risky behavior was using the mobile phone while riding (78.8%), While the least frequent risky behavior not wearing a helment (9.3%). Multivariable logistic regression analysis indicates that the factors associated with the major accidents were running a red light (aOR 2.78, 95%CI 1.07 to 7.21) and having concerns for customer behavior (aOR 2.66, 95%CI 1.26 to 5.62). The factors associated with any accidents (both major and minor accidents) were sleeping < 6 hours/day (aOR 2.13, 95%CI 1.41 to 3.21) and working ≥ 48 hours/week (aOR 1.72, 95%CI 1.04 to 2.83) To reduce the rate and severity of traffic accidents, the government and the delivery firms should provide effective strategies and targeted interventions focusing on the reduction of risky behaviors and other modifiable risk factors.