bluuebunny/crossref_metadata_2025_split huggingface dataset:
River infrastructure and the spread of freshwater invasive species: Inferences from an experimentally‐parameterised individual‐based model
Authors: Daniels Jack A. , Kerr James R. , Kemp Paul S. 
Published: March 2023

Abstract

Invasive species and river infrastructure are major threats to freshwater biodiversity. These stressors are commonly considered in isolation, yet the construction and maintenance of river infrastructure can both enhance and limit the expansion of invasive species. Spatial and temporal limitations of laboratory and field studies, coupled with little consideration of population‐level responses (e.g. invasion rate), have limited understanding of the efficacy of infrastructure for long‐term, catchment‐scale containment of invasive species.

This study utilised an individual‐based model (IBM) to investigate the ability of a partial riverine barrier to contain the spread of invasive species at large spatio‐temporal scales, using American signal crayfish Pacifastacus leniusculus as a model species. The base model (no barrier) accurately recreated longitudinal expansion rates of signal crayfish reported in existing literature. A virtual riverine barrier was added to the base model, with passage at the structure parameterised using existing literature and the results of an experiment that demonstrated no clear relationship between crayfish density and passage efficiency at a Crump weir.

Model outputs indicated a weir downstream of the release point had no effect on longitudinal expansion of crayfish, whereas an upstream barrier slowed the invasion rate for 6.5 years after it was first encountered. After the invasion rate had recovered to pre‐barrier levels, the invasion front was 2.4 km further downstream than predicted in the absence of a barrier, representing a 1.73 year delay in longitudinal range expansion.

Synthesis and applications. Despite substantial negative impacts on native biodiversity, river infrastructure can also delay the spread of freshwater invasive species, representing a trade‐off. This demonstrates the need to consider positive ecological consequences of river infrastructure when designing prioritisation techniques for barrier removal and mitigation (e.g. selective fish passage), and suggests that in some cases barriers may provide a useful integrated pest management tool.
Evaluating the ability of wetland mitigation banks to replace plant species lost from destroyed wetlands
Authors: Tillman Stephen C. , Matthews Jeffrey W. 
Published: March 2023

Abstract

Offset policies are used world‐wide as a means to compensate for destruction of ecosystems by requiring developers to restore or preserve ecosystems elsewhere. A key challenge to effectively implementing offset policies is ensuring ecological equivalence between impacted ecosystems and compensation sites, yet equivalence is rarely tested.

Using data from wetland mitigation banks and naturally occurring wetlands in Illinois, USA, we evaluated the ability of wetland offsetting to replace the plant species composition of wetlands impacted by development. We simulated the effects of three policy strategies used to promote equivalence: disallowing the replacement of one type of habitat with another, requiring a greater ratio of offset area to impacted area, and spatially restricting wetland trades.

Wetland banks replaced an average of 45% of the native plant species present in impacted natural wetlands. Allowing only in‐kind habitat replacement and quadrupling the offset ratio resulted in modest increases in the percentage of plant species replaced, but restricting trades to within counties did not.

Synthesis and application. Many of the plant species present in wetlands that are vulnerable to development were absent from wetland mitigation banks. Policies intended to ensure equivalence between impacted wetlands and banks did not ensure protection of biodiversity. If preservation of taxonomic diversity is to be a goal of offsetting, offset policies will need to ensure that offset sites have similar biophysical conditions to the ecosystems they replace.
The honeybee gut resistome and its role in antibiotic resistance dissemination
Authors: SUN Huihui , LI Hu , ZHANG Xue , LIU Yan , CHEN Hao , ZHENG Li , ZHAI Yifan , ZHENG Hao 
Published: March 2023

AbstractThere is now general concern about widespread antibiotic resistance, and growing evidence indicates that gut microbiota is critical in providing antibiotic resistance. Honeybee is an important pollinator; the incidence of antibiotic resistance genes in honeybee gut causes potential risks to not only its own health but also to public and animal health, for its potential disseminator role, thus receiving more attention from the public. Recent analysis results reveal that the gut of honeybee serves as a reservoir of antibiotic resistance genes, probably due to antibiotics application history in beekeeping and horizontal gene transfer from the highly polluted environment. These antibiotic resistance genes accumulate in the honeybee gut and could be transferred to the pathogen, even having the potential to spread during pollination, tending, social interactions, etc. Newly acquired resistance traits may cause fitness reduction in bacteria whereas facilitating adaptive evolution as well. This review outlines the current knowledge about the resistome in honeybee gut and emphasizes its role in antibiotic resistance dissemination.
Identifying stream temperature variation by coupling meteorological, hydrological, and water temperature models
Authors: Tang Chunling , Garcia Valeria 
Published: March 2023

AbstractIn this study, we demonstrate a physically based semi‐Lagrangian water temperature model known as the River Basin Model (RBM) coupled with the Variable Infiltration Capacity (VIC) hydrological model and Weather Research & Forecasting Model in the Mississippi River Basin (MRB). The results of this coupling compare favorably with observed water temperature data available from six river gages located in the MRB. Further sensitivity analysis indicates that the mean water temperatures may increase by 1.3, 1.5, and 1.8°C in northern, central, and southern MRB zones under a hypothetical uniform air temperature increase of 3.0°C. If air temperatures increase uniformly by 6.0°C in this scenario, then water temperatures are projected to increase by 3.3, 3.5, and 4.0°C. Lastly, downscaled air temperatures from a global climate model are used to drive the coupled VIC and RBM model from 2020 to 2099. Average stream temperatures from 2020 to 2099 increase by 1.0 to 8.0°C above 1950 to 2010 average water temperatures, with non‐uniform increases along the river. In some portions of the MRB, stream temperatures could increase above survival thresholds for several native fish species, which are critical components of the stream ecosystem. In addition, increased water temperatures interact with nutrient loadings from sources throughout the MRB, which is expected to exacerbate harmful algal blooms and dead zones in the Gulf of Mexico.
Mechanisms of diabetic foot ulceration: A review
Authors: Deng Haibo , Li Binghui , Shen Qian , Zhang Chenchen , Kuang Liwen , Chen Ran , Wang SiYuan , Ma ZhiQiang , Li Gongchi 
Published: March 2023

AbstractDiabetic foot ulcers (DFUs) are associated with complex pathogenic factors and are considered a serious complication of diabetes. The potential mechanisms underlying DFUs have been increasingly investigated. Previous studies have focused on the three aspects of diabetic peripheral vascular disease, neuropathy, and wound infections. With advances in technology, researchers have been gradually conducting studies using immune cells, endothelial cells, keratinocytes, and fibroblasts, as they are involved in wound healing. It has been reported that the upregulation or downregulation of molecular signaling pathways is essential for the healing of DFUs. With a recent increase in the awareness of epigenetics, its regulatory role in wound healing has become a much sought‐after trend in the treatment of DFUs. This review focuses on four aspects involved in the pathogenesis of DFUs: physiological and pathological mechanisms, cellular mechanisms, molecular signaling pathway mechanisms, and epigenetics. Given the challenge in the treatment of DFUs, we are hopeful that our review will provide new ideas for peers.
U‐shaped association between serum IGF2BP3 and T2DM: A cross‐sectional study in Chinese population
Authors: Wu Xiaoying , Wang Wei , Fan Shujin , You Lili , Li Feng , Zhang Xiaoyun , Wu Hongshi , Tang Juying , Qi Yiqin , Feng Wanting , Yan Li , Ren Meng 
Published: March 2023

AbstractObjectiveTo clarify the expression of N6‐methyladenosine (m6A) modulators involved in the pathogenesis of type 2 diabetes mellitus (T2DM). We further explored the association of serum insulin‐like growth factor 2 mRNA‐binding proteins 3 (IGF2BP3) levels and odds of T2DM in a high‐risk population.MethodsThe gene expression data set GSE25724 was obtained from the Gene Expression Omnibus, and a cluster heatmap was generated by using the R package ComplexHeatmap. Differential expression analysis for 13 m6A RNA methylation regulators between nondiabetic controls and T2DM subjects was performed using an unpaired t test. A cross‐sectional design, including 393 subjects (131 patients with newly diagnosed T2DM, 131 age‐ and sex‐matched subjects with prediabetes, and 131 healthy controls), was carried out. The associations between serum IGF2BP3 concentrations and T2DM were modeled by restricted cubic spline and logistic regression models.ResultsTwo upregulated (IGF2BP2 and IGF2BP3) and 5 downregulated (methyltransferase‐like 3 [METTL3], alkylation repair homolog protein 1 [ALKBH1], YTH domain family 2 [YTHDF2], YTHDF3, and heterogeneous nuclear ribonucleoprotein [HNRNPC]) m6A‐related genes were found in islet samples of T2DM patients. A U‐shaped association existed between serum IGF2BP3 levels and odds of T2DM according to cubic natural spline analysis models, after adjustment for body mass index, waist circumference, diastolic blood pressure, total cholesterol, and triglyeride. Multivariate logistic regression showed that progressively higher odds of T2DM were observed when serum IGF2BP3 levels were below 0.62 ng/mL (odds ratio 3.03 [95% confidence interval 1.23–7.47]) in model 4.ConclusionSeven significantly altered m6A RNA methylation genes were identified in T2DM. There was a U‐shaped association between serum IGF2BP3 levels and odds of T2DM in the general Chinese adult population. This study provides important evidence for further examination of the role of m6A RNA methylation, especially serum IGF2BP3 in T2DM risk assessment.
Delineation of Integrated Anomaly with Generative Adversarial Networks and Deep Neural Networks in the Zhaojikou Pb‐Zn Ore District, Southeast China
Authors: DUAN Jilin , LIU Yanpeng , ZHU Lixin , MA Shengming , GONG Qiuli , DOLGOPOLOVA Alla , LUDWIG Simone A. 
Published: March 2023

AbstractGeochemical maps are of great value in mineral exploration. Integrated geochemical anomaly maps provide comprehensive information about mapping assemblages of element concentrations to possible types of mineralization/ore, but vary depending on expert's knowledge and experience. This paper aims to test the capability of deep neural networks to delineate integrated anomaly based on a case study of the Zhaojikou Pb‐Zn deposit, Southeast China. Three hundred fifty two samples were collected, and each sample consisted of 26 variables covering elemental composition, geological, and tectonic information. At first, generative adversarial networks were adopted for data augmentation. Then, DNN was trained on sets of synthetic and real data to identify an integrated anomaly. Finally, the results of DNN analyses were visualized in probability maps and compared with traditional anomaly maps to check its performance. Results showed that the average accuracy of the validation set was 94.76%. The probability maps showed that newly‐identified integrated anomalous areas had a probability of above 75% in the northeast zones. It also showed that DNN models that used big data not only successfully recognized the anomalous areas identified on traditional geochemical element maps, but also discovered new anomalous areas, not picked up by the elemental anomaly maps previously.
Capturing key function‐focused care problems, nursing diagnoses, and interventions for nursing home patients using a web‐based case management system
Authors: Lee Su Jung , Park Min Sun , Chang Sung Ok 
Published: March 2023

AbstractPurposeThe aim of this study is to identify the key functional care problems, NANDA‐I nursing diagnoses, and intervention plans related to function‐focused care (FFC) using a web‐based case management system for patients who present different cognitive status.MethodsThis study employed a retrospective descriptive research design. Data were obtained from system records on patients after the research team trained the case management system at a nursing home in Dangjin in South Chungcheong Province, South Korea. A total of 119 inpatient records were analyzed.ResultsThe key physical, cognitive, and social functional problems, nursing diagnoses in six domains (health promotion, elimination and exchange, activity/rest, perception/cognition, coping/stress tolerance, and safety/protection), and intervention plans were identified.ConclusionThe identified FFC case management information of interdisciplinary caregivers will provide evidence for the implementation of effective interventions according to a patient's functional status. Additional studies related to the establishment of a large clinical database of advanced case management systems focusing on interdisciplinary caregivers’ functional management are needed to support the prioritization of functional care.
Immune regulatory cytokines in seminal plasma of healthy men: A scoping review and analysis of variance
Authors: Lyons Hannah E. , Arman Bridget M. , Robertson Sarah A. , Sharkey David J. 
Published: March 2023

AbstractObjectiveSeminal plasma cytokines are associated with fertility and reproductive health, but progressing their clinical utility is hampered by absence of reference data on concentration ranges of relevant cytokines in healthy men. We employed a systematic approach to assemble current evidence on the concentrations of immune regulatory cytokines present in seminal plasma (SP) of normozoospermic and/or fertile men and evaluated the impact of different platform methodologies for cytokine quantification.Evidence reviewA systematic literature search was performed utilising PubMed, Web of Science and Scopus. Databases were searched from inception until 30th June 2022 inclusive, using combinations of keywords pertaining to seminal fluid and cytokines, and was restricted to human participants. Original data with values reported as concentration of specific cytokines in SP of men clearly defined as fertile or normozoospermic were extracted from studies written in English.ResultsA total of 3769 publications were initially identified, of which 118 fulfilled the eligibility criteria for inclusion. A total of 51 individual cytokines are detectable in SP of healthy men. The number of studies reporting on each cytokine range from 1 to >20. The reported concentrations for many cytokines linked with fertility status, including IL6, CXCL8/IL8, and TNFA, are highly variable between published studies. This is associated with the different immunoassay methodologies utilised and may be exacerbated by a lack of validation of assays to ensure suitability for SP assessment. Due to the large variation between studies, accurate reference ranges for healthy men cannot be determined from the published data.ConclusionsThe concentrations of cytokines and chemokines detected in SP is inconsistent and highly variable between studies and cohorts, limiting current capacity to define reference ranges for cytokine concentrations in fertile men. The lack of standardisation in methods used to process and store SP, and variation in platforms used to evaluate cytokine abundance, are factors contributing to the observed heterogeneity. To progress the clinical utility of SP cytokine analysis will require standardisation and validation of methodologies so that reference ranges for healthy fertile men can be defined.
Clinical presentation and disease prevalence of captive central bearded dragons (Pogona vitticeps) at veterinary clinics in Australia
Authors: Sollom HJ , Baron HR 
Published: March 2023

Central bearded dragons (Pogona vitticeps) are one of the most popular reptile pets in Australia and around the world. Diseases, including metabolic bone disease, periodontal disease, and gastrointestinal endoparasites commonly affect captive animals. To determine the common reasons these lizards were presented to the veterinarian and to establish the prevalence of disease seen in captive P. vitticeps in Australia, this retrospective study evaluated the clinical records of three exotic pet veterinary hospitals. Records from 724 P. vitticeps were analysed, with 70 reasons for presentation and 88 diseases identified across 1000 visits to the veterinarian. Lethargy was the most reported reason for presentation (n = 181). The gastrointestinal tract (18.25%) and skin (18.25%) were the equally most commonly affected organ systems, followed by the musculoskeletal system (15.17%). Endoparasites were the most common single disease process (n = 103), followed by metabolic bone disease (n = 65), skin wounds (n = 59) and periodontal disease (n = 48). Of the patients that presented for routine preventive health examinations (n = 159), 45.30% received some form of intervention to treat or prevent disease. Many of the conditions that were identified by the veterinarians in this study are traditionally correlated with suboptimal husbandry and may be easily prevented. This study identified the common reasons for presentation to the veterinarian and the prevalence of disease in captive P. vitticeps in Australia, providing the first extensive retrospective analysis of objective reference literature for central bearded dragon owners and aspiring reptile veterinarians.
Prescribing of low‐dose rivaroxaban in patients with atherosclerotic cardiovascular disease in the United Kingdom and the Netherlands
Authors: Hunt Nicholas B. , Pajouheshnia Romin , Salih Allan , van Doorn Sander , Souverein Patrick C. , Bazelier Marloes T. , Klungel Olaf H. , Gardarsdottir Helga 
Published: March 2023

AimsLow‐dose rivaroxaban has been indicated for the management of atherosclerotic cardiovascular disease (ASCVD) after recent (2019‐2020) updates to European guidelines. We aimed to describe prescription trends of low‐dose rivaroxaban in ASCVD patients over the period 2015‐2022 in two European countries, to compare the trends before and after guideline changes, and to determine the characteristics of users.MethodsIn a cross‐sectional interrupted time series analysis, utilization of low‐dose rivaroxaban (2.5 mg, twice daily) was measured in Clinical Practice Research Datalink Aurum (United Kingdom [UK]) and the PHARMO Database Network (the Netherlands) from 1 January 2015 to 28 February 2022 in patients with an ASCVD diagnosis. Incidence rates (IRs) and incidence rate ratios (IRRs) of new use (within 182 days) compared to the reference period, 2015‐2018, were calculated. Age, sex and comorbidities of users were compared to those of nonusers.ResultsIn the UK, from 721 271 eligible subjects the IR of new use of low‐dose rivaroxaban in the period 2015‐2018, before guideline changes, was 12.4 per 100 000 person‐years and after guideline changes in 2020‐2022 was 124.0 (IRR 10.0, 95% confidence interval [CI] 8.5, 11.8). In the Netherlands from 394 851 subjects, the IR in 2015‐2018 was 2.4 per 100 000 person‐years and in 2020 was 16.3 (IRR 6.7, 95% CI 4.0, 11.4). Users were younger (UK mean difference [MD] −6.1 years, Netherlands −2.4 years; P < .05) and more likely to be male (UK difference 11.5%, Netherlands 13.4%; P < .001) than nonusers.ConclusionsThere was a statistically significant increase in the use of low‐dose rivaroxaban for the management of ASCVD after guideline changes in the UK and the Netherlands. There were international differences, but low‐dose rivaroxaban has not been put into widespread practice.
Sleep as a mediator of the relationship between social class and health in higher education students
Authors: McGuffog Romany , Rubin Mark , Boyes Mark , Caltabiano Marie L. , Collison James , Lovell Geoff P. , Muldoon Orla , Paolini Stefania 
Published: March 2023

AbstractA substantial body of research indicates that higher education students from lower social class backgrounds tend to have poorer health than those from higher social class backgrounds. To investigate sleep as a potential mediator of this relationship, online survey responses of students from five large Australian universities, one Irish university and one large Australian technical college were analysed in three studies (Study 1 N = 628; Study 2 N = 376; Study 3 N = 446). The results revealed that sleep quality, sleep duration, sleep disturbances, pre‐sleep worries and sleep schedule variability mediated the relationship between social class and physical and mental health. Sleep remained a significant mediator when controlling for related variables and other mediators. Thus, the findings suggest that sleep partly explains social class differences in health. We discuss the importance of addressing sleep issues among students from lower social class backgrounds.
Making sense of punishment: Transgressors' interpretation of punishment motives determines the effects of sanctions
Authors: de Vel‐Palumbo Melissa , Twardawski Mathias , Gollwitzer Mario 
Published: March 2023

AbstractPunishment is expected to have an educative, behaviour‐controlling effect on the transgressor. Yet, this effect often remains unattained. Here, we test the hypothesis that transgressors' inferences about punisher motives crucially shape transgressors' post‐punishment attitudes and behaviour. As such, we give primacy to the social and relational dimensions of punishment in explicating how sanctions affect outcomes. Across four studies using different methodologies (N = 1189), our findings suggest that (a) communicating punishment respectfully increases transgressor perceptions that the punisher is trying to repair the relationship between the transgressor and their group (relationship‐oriented motive) and reduces perceptions of harm‐oriented and self‐serving motives, and that (b) attributing punishment to relationship‐oriented (vs. harm/self‐oriented, or even victim‐oriented) motives increases prosocial attitudes and behaviour. This research consolidates and extends various theoretical perspectives on interactions in justice settings, providing suggestions for how best to deliver sanctions to transgressors.
COVID‐19, mental health, and rurality: A pilot study
Authors: Deacon Leith , Sarapura Silvia , Caldwell Wayne , Epp Sara , Ivany Miranda , Papineau Jacob 
Published: March 2023

AbstractCOVID‐19 has caused enormous economic and social disruptions that may have lasting effects on employment, income, and working conditions. Critically, these disruptions often have a negative impact on mental health. While significant research has examined the relationship between COVID‐19 and mental health, most of these studies focus on urban centres. This paper presents results from a pilot study conducted in two rural counties in Ontario, Canada on the experiences of residents from small and rural communities related to COVID‐19. Based on 3496 survey results, this study quantifies the negative impact of COVID‐19 on overall mental health and the confounding role of gender, income, and age. Results must be used to expand the dialogue around rural mental health and to ensure appropriate programs and policies are developed.