bluuebunny/crossref_metadata_2025_split huggingface dataset:
Volumetric Analysis of the Sinus and Orbit in Silent Sinus Syndrome After Endoscopic Sinus Surgery
Authors: Amin Dev , Chitguppi Chandala , Xu Vivian , Haghshenas Cameron , Gorniak Richard , Rabinowitz Mindy , Toskala Elina , Rosen Marc , Nyquist Gurston 
Published: January 2023

AbstractObjectiveThe term “silent sinus syndrome” (SSS) describes spontaneous enophthalmos secondary to subclinical maxillary sinus atelectasis. Debate remains on whether treatment with endoscopic maxillary antrostomy alone is adequate in reversing atelectasis and globe displacement. This study aims to determine the degree of volume change of the diseased sinus and orbit as well as the change in orbital height in patients treated with endoscopic antrostomy without orbital floor augmentation.Study DesignRetrospective review with image analysis.SettingSingle tertiary care institution.MethodsThree‐dimensional (3D) analysis of computed tomographic imaging data was performed using 3D Slicer. 3D models of the maxillary sinus and orbit of the diseased and normal sides were created, and volume measurements were calculated using the segmentation program.ResultsThirteen patients with SSS who underwent endoscopic sinus surgery (ESS) and had follow‐up computed tomographic imaging were analyzed. After endoscopic antrostomy, the mean volume of the diseased maxillary sinus significantly increased by 9.82%, from 6.37 to 7.00 cm3 (p = .0302). There was no significant change in mean orbital volume; however, the mean orbital height decreased by 5.67%, from 38.09 to 35.93 mm from pretreatment to posttreatment samples (p = .0101). All patients had resolution of clinical or radiographic enophthalmos and orbital displacement with ESS alone.ConclusionEndoscopic maxillary antrostomy alone in the treatment of SSS significantly increased maxillary sinus volume and decreased diseased orbital height. These changes were associated with clinical and radiographic improvement in globe displacement. These findings support performing ESS alone, reserving orbital augmentation for patients who do not exhibit adequate clinical improvement.
Tap‐Tap: Learning Endonasal and Percutaneous Nasal Osteotomy Techniques on 3D‐Printed Midface Models
Authors: Schlegel Lauren , Kumar Ayan , Christopher Vanessa , Belko Sara , Barbarite Eric , Pugliese Robert , Krein Howard , Hutchinson Morgan , Heffelfinger Ryan 
Published: January 2023

AbstractNasal osteotomy is one of the most challenging steps of rhinoplasty. Lack of hands‐on training and confidence with this procedure adds to the complexity for learners and trainees. As three‐dimensional (3D) printing becomes increasingly accessible, simulation on 3D printed models has the potential to address this educational need in a safe, reproducible, and clinically realistic manner. The simulation session described in this communication, which utilized our low‐cost, 3D‐printed nasal osteotomy ($12.37) task trainer, produced both educational and confidence benefits for trainees. Here we describe the design, organization, curriculum, and pilot data for a 3D‐printed nasal osteotomy task trainer for the simulation of endonasal and percutaneous nasal osteotomy.
Twelve‐Month Outcomes of Simultaneous Translabyrinthine Resection and Cochlear Implantation
Authors: Doerfer Karl W. , Fritz Christian G. , Porps Sandra L. , Hong Robert S. , Jacob Jeffrey T. , Babu Seilesh C. 
Published: January 2023

AbstractObjectiveAudiometric outcomes at 12 months following simultaneous translabyrinthine (TL) resection of vestibular schwannoma (VS) and cochlear implantation (CI).Study DesignProspective cohort study.SettingTertiary referral center.MethodsAdult patients undergoing TL resection of sporadic, unilateral VS ≤ 2 cm were prospectively enrolled. Preoperative testing included binaural AZBio in noise and quiet and unilateral Consonant‐Nucleus‐Consonant (CNC). Tinnitus Handicap Index (THI) and Speech, Spatial, and Qualities of Hearing (SSQ) questionnaires were also completed. Patients underwent TL resection with simultaneous CI. The preoperative test battery was repeated at 1, 3, 6, and 12 months after activation. Statistical analysis was performed to characterize short‐term outcomes (preoperative to 3 months), longer‐term outcomes (3‐12 months), and overall changes during the preoperative to 12‐month period.ResultsAZBio, CNC, and THI improved at 3 months with no significant changes thereafter and showed durable improvement at 12 months compared to preoperative testing. While SSQ did not improve at 12 months, a subset of patients showed either recovery or improvement of SSQ‐spatial subscores. Patients with cerebellopontine angle tumors had poorer performance, although the impact of tumor size and location could not be deduced based on the small sample size.ConclusionPatients undergoing simultaneous CI and TL resection of VS had durable improvements in speech perception and tinnitus severity 12 months following surgery. Subjective improvements in localization were not observed. Additional studies are needed to determine which VS patients are optimal candidates for CI.
Identification of micro‐failure processes of HDPE‐henequen fiber composite material by using acoustic emission monitoring: Effect of fiber surface modification
Authors: Anaya‐Ramirez Roberto Carlos , Rios‐Soberanis Carlos Rolando , Herrera‐Franco Pedro Jesus 
Published: January 2023

AbstractIt is well known that fiber‐matrix interface region is crucial to ensure an efficient stress transfer between matrix and reinforcement and that it controls the composite behavior when subjected to external loads. In this experimental study, micro‐damage mechanisms of HDPE/surface modified henequen fiber reinforced composites are investigated in tensile quasi‐static mode. Two essential parameters of the materials composition were taken as main indicators: fiber length and quality of the fiber matrix adhesion. Essential Work of Fracture theory (EWF) was applied on double edge notch tensile (DENT) specimen geometry. Acoustic Emission (AE) technique was coupled to composite samples to obtain the characteristics of stress waves signals to monitor in real time damage evolution and failure mechanisms detection. Results demonstrated the substantial effect of chemical bonds interaction in the interface area on the composite mechanical properties. The total fracture work (Wf) exhibited an increasing value in both components, We and Wp, in chemically treated fiber composites. Likewise, mechanical properties are reported to be higher by 37% in maximum load in such materials. Elastic waves detected by AE were identified and correlated to micromechanical events during composite damage sequence. Most of the signals corresponded to microcracks (signals of low amplitude, short duration), propagation of microcracks (signals of medium amplitude), fracture of fibers and matrix (signals of long duration and high amplitude). AE signals detected exhibiting higher energy were associated to an enhanced fiber/matrix interface.
Populus endo‐glucanase 16 localizes to the cell walls of developing tissues
Authors: Behar Hila , Mottiar Yaseen , Chandrasekhar Rohan , Grappadelli Allegra Corelli , Pauly Markus , Samuels A. Lacey , Mansfield Shawn D. , Brumer Harry 
Published: January 2023

AbstractThe hemicelluloses comprise a group of matrix glycans that interact with cellulose microfibrils in plant cell walls and play important roles in establishing wall architecture. The structures of hemicelluloses are determined by carbohydrate‐active enzymes (CAZymes) that synthesize, integrate, and break down these polymers. Specifically, endo‐glucanase 16 (EG16) enzymes, which are related to the well‐known xyloglucan endotransglycosylase/hydrolase (XTH) gene products in Glycoside Hydrolase Family 16 (GH16), have been implicated in the degradation of the β(1,4)‐linked backbone of mixed‐linkage β(1,3);β(1,4)‐glucans (MLG) and xyloglucans. EG16 members are single‐copy genes found in most plant clades but are absent from many eudicots, including the model plant Arabidopsis thaliana. Until recently, EG16 members had only been characterized in vitro, establishing their substrate specificity, protein structure, and phylogenetic history, but their biological function was unknown. Here we used a hybrid polar, Populus alba × Populus grandidentata (P39), as a model to examine EG16 expression, subcellular localization, and pheno‐ and chemotypes of EG16‐downregulated P39 plants. Populus EG16 expression is strong in young tissues, but RNAi‐mediated downregulation did not impact plant growth nor the fine structure of the hemicellulose xyloglucan, suggesting a restricted or currently unknown role in angiosperm physiology.
Can lung ultrasound score accurately predict surfactant replacement? A systematic review and meta‐analysis of diagnostic test studies
Authors: Capasso Letizia , Pacella Daniela , Migliaro Fiorella , Salomè Serena , Grasso Fiorentino , Corsini Iuri , De Luca Daniele , Davis Peter G. , Raimondi Francesco 
Published: January 2023

AbstractBackgroundClinical and radiographic criteria are traditionally used to determine the need for surfactant therapy in preterm infants. Lung ultrasound is a bedside test that offers a rapid, radiation‐free, alternative to this approach.ObjectiveTo conduct a systematic review and meta‐analysis to determine the accuracy of a lung ultrasound score (LUS) in identifying infants who would receive at least one surfactant dose. Secondary aims were to evaluate the predictive accuracy for ≥2 doses and the accuracy of a different image classification system based on three lung ultrasound profiles.MethodsPubMed, SCOPUS, Biomed Central, and the Cochrane library between January 2011 and December 2021 were searched. Full articles enrolling preterm neonates who underwent lung ultrasound to predict surfactant administration were assessed and analyzed following Preferred Reporting Items for Systematic Review and Meta‐Analysis Protocols (PRISMA‐P) and QUADAS‐2 guidelines.ResultsSeven prospective studies recruiting 697 infants met the inclusion criteria. Risk of bias was generally low. Oxygen requirement, clinical and radiographic signs of respiratory distress syndrome were used as reference standards for surfactant replacement. The summary receiver operator characteristic (sROC) curve for LUS predicting first surfactant dose showed an area under the curve (AUC) = 0.88 (95% confidence interval [CI]: 0.82–0.91); optimal specificity and sensitivity (Youden index) were 0.83 and 0.81 respectively. Pooled estimates of sensitivity, specificity, diagnostic odds ratio, negative predictive value, and positive predictive value for LUS predicting the first surfactant dose were 0.89 (0.82–0.95), 0.86 (0.78–0.95), 3.78 (3.05–4.50), 0.92 (0.87–0.97), 0.79 (0.65–0.92). The sROC curve for the accuracy of Type 1 lung profile in predicting first surfactant dose showed an AUC of 0.88; optimal specificity and sensitivity were both 0.86. Two studies addressing the predictive accuracy of LUS for ≥2 surfactant doses had high heterogeneity and were unsuitable to combine in a meta‐analysis.DiscussionDespite current significant variation in LUS thresholds, lung ultrasound is highly predictive of the need for early surfactant replacement. This evidence was derived from studies with homogeneous patient characteristics and low risk of bias.
Migration and development, without care? Locating transnational care practices in the migration‐development debate
Authors: Withers Matt , Hill Elizabeth 
Published: January 2023

AbstractHighly‐restrictive temporary labour migration schemes are commonplace throughout the Indo‐Pacific region and continue to expand amid sustained policy enthusiasm for ‘migration‐development’. Yet, the developmental benefits of guestworker schemes are routinely evaluated according to narrow economic criteria, with little consideration given to transnational family separation and the displacement of socially reproductive labour that sustains everyday life. ‘Migration’, ‘development’ and ‘care’ are deeply interlinked political economic processes, yet they have been theorised in partial isolation. We challenge this analytical disconnect, situating the developmental implications of guestworker migration in relation to the total social organisation of labour, and argue for a more holistic ‘migration‐care‐development' nexus that foregrounds unsustainable disruptions to care economies. We ground our framework in the context of Australia's Pacific Labour Scheme to illustrate the developmental consequences for Pasifika households and communities, highlighting the need for ‘decent care’ policies to address care deficits in support of sustainable and gender‐equitable development.
Achieving herd immunity against COVID‐19 in the Philippines
Authors: Cedeño Trisha Denise D. , Rocha Ian Christopher N. , Miranda Adriana Viola , Lim Leonard Thomas S. , Buban Julian Mikhael A. , Cleofas Jerome V. 
Published: January 2023

AbstractAchieving herd immunity is crucial for the Philippines, which continues to struggle and recover from the grave impacts of the pandemic, especially regarding its health and socioeconomic sectors. As of November 2022, 65% Filipinos have been vaccinated, nearing the 70% target. Despite this progress, vaccination efforts in the Philippines remain challenged with vaccine hesitancy, unequal distribution, and limitations of the cold chain logistics. This commentary sheds light on the current state of COVID‐19 in the Philippines and discusses the importance and challenges of its pandemic response, in the pursuit of herd immunity within a developing country.
Comparison of multivariate post‐processing methods using global ECMWF ensemble forecasts
Authors: Lakatos Mária , Lerch Sebastian , Hemri Stephan , Baran Sándor 
Published: January 2023

AbstractAn influential step in weather forecasting was the introduction of ensemble forecasts in operational use owing to their capability to account for the uncertainties in the future state of the atmosphere. However, ensemble weather forecasts are often underdispersive and might also contain bias, which calls for some form of post‐processing. A popular approach to calibration is the ensemble model output statistics approach resulting in a full predictive distribution for a given weather variable. However, this form of univariate post‐processing may ignore the prevailing spatial and/or temporal correlation structures among different dimensions. Since many applications call for spatially and/or temporally coherent forecasts, multivariate post‐processing aims to capture these possibly lost dependencies. We compare the forecast skill of different non‐parametric multivariate approaches to modeling temporal dependence of ensemble weather forecasts with different forecast horizons. The focus is on two‐step methods, where, after univariate post‐processing, the ensemble model output statistics predictive distributions corresponding to different forecast horizons are combined to a multivariate calibrated prediction using an empirical copula. Based on global ensemble predictions of temperature, wind speed, and precipitation accumulation of the European Centre for Medium‐Range Weather Forecasts from January 2002 to March 2014, we investigate the forecast skill of different versions of ensemble copula coupling (ECC) and Schaake shuffle. In general, compared with the raw and independently calibrated forecasts, multivariate post‐processing substantially improves the forecast skill. Although even the simplest ECC approach with low computational cost provides a powerful benchmark method, recently proposed advanced extensions of the ECC and the Schaake shuffle are found to not provide any significant improvements over their basic counterparts.
Circular economy at the company level: An empirical study based on sustainability reports
Authors: Heras‐Saizarbitoria Iñaki , Boiral Olivier , Testa Francesco 
Published: January 2023

AbstractCircular economy (CE) has attracted both media and academic interest. However, there is a lack of empirical work that clarifies the specific activities involved in CE at the firm level. To fill this gap, this article offers an analysis of how firms disclose information about their activities associated with CE, based on an extensive worldwide dataset of sustainability reports from 1367 companies. The findings point to a rather limited, superficial and reductionist use of the concept of CE by firms. The concept of CE is only mentioned in around 16% of cases, and, when it is mentioned, it is mostly associated with conventional practices such as waste management and recycling. Conversely, core practices associated with CE, such as reduction, reuse, and remanufacture, are rarely considered. Further avenues for research and implications for managers, public policy makers and other stakeholders are discussed.
Rapid Fabrication of High‐Permeability Mixed Matrix Membranes at Mild Condition for CO2 Capture
Authors: Li Shuo , Sun Yu‐Jie , Wang Zhao‐Xu , Jin Cheng‐Gang , Yin Ming‐Jie , An Quan‐Fu 
Published: January 2023

AbstractMixed matrix membranes (MMMs), conjugating the advantages of flexible processing‐ability of polymers and high‐speed mass transfer of porous fillers, are recognized as the next‐generation high‐performance CO2 capture membranes for solving the current global climate challenge. However, controlling the crystallization of porous metal‐organic frameworks (MOFs) and thus the close stacking of MOF nanocrystals in the confined polymer matrix is still undoable, which thus cannot fully utilize the superior transport attribute of MOF channels. In this study, the “confined swelling coupled solvent‐controlled crystallization” strategy is employed for well‐tailoring the in‐situ crystallization of MOF nanocrystals, realizing rapid (<5 min) construction of defect‐free freeway channels for CO2 transportation in MMMs due to the close stacking of MOF nanocrystals. Consequently, the fabricated MMMs exhibit approximately fourfold enhancement in CO2 permeability, i.e., 2490 Barrer with a CO2/N2 selectivity of 37, distinctive antiplasticization merit, as well as long‐term running stability, which is at top‐tier level, enabling the large‐scale manufacture of high‐performance MMMs for gas separation.
Bioactive Peptide Nanodrugs Based on Supramolecular Assembly for Boosting Immunogenic Cell Death‐Induced Cancer Immunotherapy
Authors: Liu Yamei , Chang Rui , Xing Ruirui , Yan Xuehai 
Published: January 2023

AbstractImmunogenic cell death (ICD)‐induced immunotherapy holds promise for complete elimination and long‐term protective immune responses against cancer by combining direct tumor cell killing and antitumor immune response. Some therapeutic approaches (such as hyperthermia, photodynamic therapy, or radiotherapy) and inducers (certain chemotherapy drugs, oncolytic viruses) have been devoted to initiating and/or boosting ICD, leading to the activation of tumor‐specific immune responses. Recently, supramolecular assembled bioactive peptide nanodrugs have been employed to improve the efficacy of ICD‐induced cancer immunotherapy by increasing tumor targeted accumulation as well as responsive release of ICD inducers, directly inducing high levels of ICD and realizing the simultaneous enhancement of immune response through the immune function of the active peptide itself. Here, the authors review bioactive peptide nanodrugs based on supramolecular assembly, mainly as an intelligent delivery system, a direct ICD inducer and an immune response enhancer, for boosting ICD induced cancer immunotherapy. The functions of diverse bioactive peptides used in the construction of nanodrugs are described. The design of a supramolecular assembly, the mechanism of boosting ICD, and synergetic effects of bioactive peptides combined immunotherapy are critically emphasized.
A wheat chromosome segment substitution line series supports characterization and use of progenitor genetic variation
Authors: Horsnell Richard , Leigh Fiona J. , Wright Tally I. C. , Burridge Amanda J. , Ligeza Aleksander , Przewieslik‐Allen Alexandra M. , Howell Philip , Uauy Cristobal , Edwards Keith J. , Bentley Alison R. 
Published: January 2023

AbstractGenome‐wide introgression and substitution lines have been developed in many plant species, enhancing mapping precision, gene discovery, and the identification and exploitation of variation from wild relatives. Created over multiple generations of crossing and/or backcrossing accompanied by marker‐assisted selection, the resulting introgression lines are a fixed genetic resource. In this study we report the development of spring wheat (Triticum aestivum L.) chromosome segment substitution lines (CSSLs) generated to systematically capture genetic variation from tetraploid (T. turgidum ssp. dicoccoides) and diploid (Aegilops tauschii) progenitor species. Generated in a common genetic background over four generations of backcrossing, this is a base resource for the mapping and characterization of wheat progenitor variation. To facilitate further exploitation the final population was genetically characterized using a high‐density genotyping array and a range of agronomic and grain traits assessed to demonstrate the potential use of the populations for trait localization in wheat.
Engaging with Family Literacy Scholarship: Bearing Witness to Scholars and Families of Color
Authors: Compton‐Lilly Catherine , Ellison Tisha Lewis , Rogers Rebecca 
Published: January 2023

AbstractAcross research, policy, and practice, the experiences, knowledge, and collective experiences of Families of Color have been routinely erased, disregarded, and ignored, despite their potential for engaging and motivating students, creating inclusive classrooms, and addressing educational inequities. In this metasynthesis, we explicitly focus on what can be learned from Scholars of Color who have strong affinities to research communities and study the language and literacy practices of families. We attend to research findings that are relevant to children and families. We focus on four particularly salient sets of findings related to: 1. Family strengths and resources; 2. In‐betweenness, 3. Past, present, future and intergenerational connections; and 4. Advocacy and agency.
Effect of neonatal immunoglobulin status on the outcomes of spring‐born suckler calves
Authors: Bragg Rachel , Corbishley Alexander , Lycett Samantha , Burrough Elizabeth , Russell Geraldine , Macrae Alastair 
Published: January 2023

AbstractBackgroundSuccessfully rearing beef calves to weaning and beyond determines the economic performance of a beef farm. As such, it is important to understand the factors influencing performance outcomes.MethodsThis study recorded the health events, mortality and growth rates of 674 calves born on 50 commercial beef farms in Great Britain using a postsampling questionnaire. All calves had a known postcolostral serum IgG status.ResultsPreweaning mortality in the study population was 1.5% (10/674 calves), while the treatment rate was 6.4% (43/674 calves). Serum IgG, calf sex and dystocia were significant predictors of whether a calf died and/or required treatment. Average daily liveweight gain was calculated for calves where weaning weights were provided (n= 513). Serum IgG and calf sex were consistent predictors of calf growth rates, while birthweight and whether the calf was born to a cow or heifer were predictive in a model where average daily liveweight gain was converted to a binary response variable using the mean average daily liveweight gain on the calf's farm of origin.LimitationsMorbidity and mortality were lower than comparable studies, potentially due to limitations in the study design.ConclusionSerum IgG and calf sex were significant explanatory variables that affected beef calf average daily liveweight gain. For every 5 g/L increase in serum IgG, the odds ratio of dying and/or requiring treatment decreased by 0.86.