bluuebunny/crossref_metadata_2025_split huggingface dataset:
HBV integration affect the efficacy of systematic drug therapy after radical resection of liver cancer: a prospective cohort study
Authors: Li Zixiong , Chen Chao , Si Anfeng , Qu Wenshu , Zhang Jue , Xia Zhaojun , Luo Linhua , Zhang Yuanjing , Liu Xiufeng 
Published: January 2023

Abstract
Objective: HBV gene integration event is an important factor to reveal the occurrence and development of HBV-HCC, but its role in the clinical treatment of liver cancer is still unclear. This study intends to collect HCC patients, find HBV integration events based on whole genome sequencing (WGS), and finally determine their impact on the clinical prognosis of patients.
Method: After strict screening of inclusion and exclusion criteria, 20 HBV-HCC patients were finally included, and the whole genome of cancer tissue was sequenced to identify HBV gene integration events. After systematic drug treatment (TKIs or combined with ICIs), the efficacy was evaluated based on RECIST 1.1 criteria. COX regression model was used to analyze the factors affecting PFS and OS of HCC patients, and Kaplan-meier method was used to draw the survival curve.
Result: In this study, a total of 20 HBV-HCC patients were included, and HCC tissue samples were sequenced and matched with standard sequence. Among them, HBV integration events were found in 10 HBV-HCC patients, and the highest number of integration events in a single sample was 7. The highest frequency of HBV integration occurred on chromosome 5. The baselines of non-integration group and integration group are consistent and comparable. Survival analysis showed that HBV integration was a risk factor for HCC recurrence, with HR value of 3.366, P=0.019. However, in the PFS outcome of first-line systematic drug treatment, there was no significant difference between the two groups, P=0.313. Compared with the control group, the survival period of HCC patients with HBV integration was shorter, HR (95% CI): 6.335 (1.237-32.446) (P=0.027). In terms of the choice of different treatment methods, due to the limited sample size, the differences observed were not statistically significant.
Conclusion: HBV integration event is not only a risk factor for the occurrence and development of HCC, but also a risk factor for the recurrence of HBV-HCC patients after surgery. The highest frequency of HBV integration occurred on chromosome 5. HBV integration events significantly shortened the survival period of patients, and should be actively intervened in the early postoperative period.
What dictates alkane isomerization? A combined density functional theory and information-theoretic approach study
Authors: Luo Chenyu , He Xin , Zhong Aiguo , Liu Shubin , Zhao Dongbo 
Published: January 2023

Abstract
Alkanes are deceptively simple in their geometric structures, yet their electronic structures are a tough nut to crack. We employ two total energy partition schemes in density functional theory and the information-theoretic approach quantities to dissect the so-called isomerization problem. From our validation results, we have found theoretical methods, basis sets, dispersion corrections, and numerical integration grids all make contributions to the total energy difference. We highly recommend that PBE0-D3(BJ)/def2-QZVPP is a good choice for studying the longer alkane isomerization issue. We further find that the electrostatic potential dominates the isomerization of alkanes, provided that empirical dispersion is added. This observation contrasts the commonly held belief that electron delocalization dictates alkane isomerization. We also find that molecular polarizability can be linearly correlated with some ITA quantities (such as Shannon entropy and Fisher information), indicating that simple density-based functions can be good descriptors of molecular properties.
The effect of hinokitiol agaist three plant pathogenic fungi and toxicity of hinokitiol to cucumber
Authors: hongjie liang , xiongfei luo , Zhi-Jun Zhang , Shao-Yong Zhang , Jun-Xia An , yinqian liu 
Published: January 2023

Abstract
In the present study, the effect of hinokitiol agaist Sclerotinia sclerotiorum, Rhizoctonia solani, and Botrytis cinerea and toxicity of hinokitiol to cucumber were determined. Overall, hinokitiol showed the promising antifungal activity against S. sclerotiorum both in vitroand in vivo. The results showed that hinokitiol inhibited cucumber seed germination and leaves photosynthesis, and had no obvious effect on the normal growth of seedlings. We also found that after the root treatment of hinokitiol at 50 µg/mL, cucumber seedlings wilted. Thestudy investigated hinokitiol had moderateantimicrobial activity and its preventive effect is significant. Hinokitiol is a promising spray fungicide candidate for stems and leaves rather than seed and root treatments.
Named Entity Recognition of Kumauni Language using Machine Learning (ML)
Authors: Pant Vinay Kumar , Sharma Rupak , Kundu Shakti 
Published: January 2023

Abstract
Communication between humans is impossible without the use of language. Natural Language Processing (NLP) is a technique that is used so that computers can comprehend various natural languages. Named Entity Recognition (NER) is a subtask of information extraction that aims to discover and categorize the components in given text into pre-defined categories. NER is an abbreviation for the phrase ”named entity recognition”. Machine translation, question-answering systems, and automatic summarization are exam- ples of the types of NLP tasks that can benefit from NER. The purpose of this research is to investigate whether or if it is possible to create a chatbot that converses in the Kumaon language, as well as any poten- tial difficulties that could arise in the process. In addition to this, the authors provide an in-depth exami- nation of Kumaoni as well as a mapping of the language into other languages to make its use in industrial processing more accessible.
Multi-agent Collaborative Participation of Agricultural Machinery Service, High Quality Operation and Agricultural Production Efficiency: A Case Study of Conservation Tillage Technology
Authors: Zhang Fan , Shi Qingzhe , Cheng Guoqiang 
Published: January 2023

Abstract
The improvement of agricultural production efficiency is of great significance to eliminate rural poverty and ensure food security.Taking conservation tillage technology as an example, this paper analyzes the background and characteristics of multi-agent collaborative participation in agricultural machinery service. It analyzes the direct impact of agricultural machinery services provided by multi-service agents on farmers' agricultural production efficiency and the intermediary effect transmitted through high-quality conservation tillage operation by using intermediary effect model, based on survey data of four locations in the black soil region of China in 2021. The results show that: (1) The Agricultural Machinery Service with Multi-agent Collaborative Participation is characterized by its comprehensive service content, full service content, and high service availability, and the cooperative mode primarily demonstrates technical collaboration, service collaboration, and benefit collaboration; (2) The agricultural machinery service with multi-agent collaborative participation has a direct positive effect on agricultural production efficiency; (3) The agricultural machinery service with multi-agent collaborative participation has a significant impact on the high-quality operation of conservation tillage. The better the collaborative effect of multi-agent collaborative participation of agricultural machinery service, the higher the quality of farmers' conservation tillage operation; (4) High-quality conservation tillage operation can effectively improve agricultural production efficiency and play an intermediary effect in the influence of service of agricultural machinery with the cooperation of multiple service subjects on agricultural production efficiency. Under the background of the shortage of agricultural labor force and the increasingly serious pressure of aging in China, we should upgrade the service of agricultural machinery based on single transactional service to multi-agent cooperation, improve the development quality of multi-agent service consortium of agricultural machinery, and provide corresponding policy support measures such as compensation, financial credit and management evaluation, so as to promote the improvement of agricultural production efficiency and ensure national food security.
KVMod - A novel approach to designKey-Value NoSQL databases
Authors: DOURHRI Ahmed , HANINE Mohamed , OUAHMANE Hassan 
Published: January 2023

Abstract

The growth of structured, semi-structured, and unstructured data produced by the new applications is a result of the development and expansion of social networks, the Internet of Things, web technology, mobile devices, and other technologies. However, as traditional databases became less suitable to manage rapidly growing data quantity and the variety of data structures, a new class of database management systems named NoSQL is required to satisfy the new requirements. Although NoSQL databases are generally schemaless, significant research has been conducted on NoSQL design. A literature review presented in this paper let us claim the need to create modeling techniques to describe how to structure data in NoSQL databases. Key-value is one of the NoSQL families, which has received too little attention, especially about its design methodology. Most studies have focused on the other families like column-oriented and document-oriented. This paper aims to present a design approach named KVMod (key-value modeling) specific to key-value databases. The purpose is to provide to the scientific community and engineers a methodology for the design of key-value stores using the maximum automation and therefore the minimum human intervention, which equals the minimum of errors. A software tool called KVDesign has been implemented to automate the proposed methodology and thus the most time-consuming database modeling tasks. The complexity is also discussed to assess the efficiency of our proposed algorithms.
Numerical simulation research on UDF flexible roll forming of multi-specification thin-walled circular tubes
Authors: Cao Jianguo , Wang Xuesong , Ruan Kang , Cheng Jiaojiao , Wei Zhidong , Zhao Rongguo 
Published: January 2023

Abstract
In view of the problems of poor flexibility of conventional roll forming of circular tubes, the UDF (USTB-Durable F) flexible roll forming method was used to model and simulate five kinds of thin-walled circular tubes with different thicknesses and the same outer diameter, so as to verify the applicability of UDF flexible roll forming method. In order to realize the commonality of UDF rolls, according to the roll positions of seven kinds of thin-walled circular tubes with different outer diameters and thicknesses within the specification range, mathematical models between tube specifications and corresponding roll position parameters were established. Combined with the actual parameters of the thin-walled circular tube roll forming unit, the UDF forming process suitable for the flexible forming of thin-walled circular tubes was obtained and compared with the conventional process by finite element simulation. Results show that the edge molding quality of the UDF process is better than that of the conventional process, and the amount of springback is less and the accuracy of the outer diameter of the section is high. The establishment of the roll position mathematical model and the special process parameters of the UDF flexible roll forming method provides a reference for the development of flexible production of roll forming of circular tubes.
Predicted configuration and stability of ATAD2/SOX10 complex
Authors: Lehrer Steven , Rheinstein Peter H. 
Published: January 2023

Abstract
Background: ATAD2, a melanoma competence factor, forms a protein complex with SOX10 that facilitates expression of SOX10 developmental target genes. The complex enables a strong transcriptional response to oncogenes such as BRAFV600E and is sufficient to endow oncogenic competence to melanocytes. This elucidation of the ADAT2/SOX10 complex structure may facilitate the development of drugs that can block complex formation.
Methods: We have used the ClusPro web server for protein-protein docking to visualize and analyze the complex and GROMACS to perform molecular dynamics simulation.
Results: ClusPro protein docking analysis demonstrates the central position of ADAT2 in the ADAT2/SOX10 complex. Molecular dynamics simulation of ATAD2 docked to SOX10 suggest that ATAD2/SOX10 is not a stable structure.
Conclusion: The central position of ADAT2 in the complex suggests that complexed ADAT2 may have the capability to modify multiple SOX10 functions, one of which allows BRAFv600e to impart increased oncogenic function to melanocytes. The results of molecular dynamics simulation imply that the ADAT2/SOX10 complex is not stable and might be disrupted by a therapeutic molecule, reducing the risk of melanoma. Knowledge of the ADAT2/SOX10 complex structure may facilitate the development of drugs that can block complex formation.
Prevalence of behavioral problems among 6-to-14-year children with asthma and without asthma
Authors: Xiang Yuanyuan , Shi Daiyu , Li Guirong , Bao Kai , Wang Ying , Li Yuanlin , Gao Wenlong , Zhang Rongfang 
Published: January 2023

Abstract
Background
Asthma and psychological-behavioral problems co-occur more frequently than would be expected based on chance. Several previous studies have shown that the association between childhood asthma and behavioral problems was unclear.
Methods
Three hundred and thirty seven 6-to-14-year children with asthma in a case group and 674 children without asthma in a control group, matched with age and sex in 1:2, was investigated from Gansu Provincial Maternal and Child Health Hospital. We obtained socio-demographic data on children and health-seeking caregivers. The Rutter’s Behaviour Scale for Children (Parents’ Scale) (RBSC-PS) was used to assess children’ behavioral problems. The quantitative relationship between childhood asthma and behavioral problems was evaluated with a conditional logistic regression.
Results
The overall prevalence of behavioral problems in the case group and the control group were 37.39% and 18.69% respectively, and the prevalence of type A, M, and N behavioral problems in the case group were all higher than those in the control group respectively (A:14.54% vs 10.68%; M: 6.53% vs 4.15%; N: 16.32% vs 3.86%). The results of multiple conditional logistic regression analysis showed that a statistically significant association was found between childhood asthma and behavior problems (adjusted odds ratio (aOR) = 1.46; 95% confidence interval (95%CI):1.16 ~ 1.83); The regression analysis for different types of behavioral problems showed that type A behavioral problem (aOR = 1.25;95%CI:0.91 ~ 1.71) or type M (aOR = 1.20; 95%CI:0.77, 1.88) were not associated with childhood asthma but type N behavioral problem had a statistically significant association with childhood asthma(aOR = 1.90;95%CI:1.40 ~ 2.57).
Conclusion
The type N behavioral problem was associated with childhood asthma, highlighting the importance of behavioral problem prevention for children with asthma in pediatric asthma clinics.
Early onset-caloric restriction alleviates ageing-associated steatohepatitis in male mice via restoring mitochondrial homeostasis
Authors: Chiang Chun-Hsien , Li Sin-Jin , Lin Yu-Han , Wang Pei-Yu , Hsu Pu-Sheng , Lin Shau-Ping , Chiang Ting-Chia , Chen Ching-Yi 
Published: January 2023

Abstract
Non-alcoholic fatty liver disease is associated with ageing, and impaired mitochondrial homeostasis is the main cause for hepatic ageing. Caloric restriction (CR) is a promising therapeutic approach to reduce fatty liver. The present study aimed to investigate the effect of early onset CR on decelerating the progression of ageing-related steatohepatitis. The potential mechanisms regarding to mitochondria were further evaluated. Eight-week-old C57BL/6 male mice (n = 21) were randomly divided into three groups, Young-AL (AL, ad libitum), Aged-AL, and Aged-CR (60% intake of AL). Mice were sacrificed at the age of 7 months (Young) or 20 months (Aged). Aged-AL mice displayed the greatest body weight, liver weight and liver relative weight among treatments. Ageing caused a great grade of steatosis, lipid peroxidation, inflammation, and fibrosis in the liver. Mega mitochondria with short, randomly organized crista were noticed in the aged liver. CR ameliorated these negative phenomena in aged liver. Ageing was accompanied with a lower level of hepatic ATP, while CR restored it. Mitochondrial-related protein expressions of respiratory chain complexes (NDUFB8 and SDHB), and fission (DRP1) were suppressed in aged liver. Proteins related to mitochondrial biogenesis (TFAM), and fusion (MFN2) were upregulated in aged liver. CR reversed the expressions of SDHB, TFAM, DRP1, and MFN2 in aged liver. To conclude, early onset CR significantly prevented the negative effect of ageing-associated steatohepatitis, including lipid peroxidation, inflammation, steatosis and fibrosis. Moreover, CR eased ageing-associated energy deficit in liver partially via maintaining mitochondrial homeostasis.
The Fuzzy Traveling Salesman problem with FuzzyEdge Weight: Formulation and A Genetic Algorithm
Authors: Dey Arindam 
Published: January 2023

Abstract
The traveling salesman problem is a fundamental and well knownclassical combinatorial network optimization problem in operation research,where the TSP finds a shortest path/route through a collection of n nodessuch that each and every node are visited exactly one time except for thestarting node. In TSP, the arc lengths are generally considered to representthe traveling time or traveling cost rather than geographical distance. It isnot possible to predict the exact arc length because the traveling time ortraveling cost fluctuated with payload, weather, traffic conditions and so on.Fuzzy set theory provides a new tool to handle the uncertainties in TSP. Inthis paper, we concentrate on TSP on a fuzzy network in which trapezoid fuzzynumber, instead of real number, is assigned to edge as edge weight. The gradedmean integration method of fuzzy numbers is applied to solve the additionoperation and defuzzification/ranking operation of fuzzy number. We proposea mathematical model for a TSP with fuzzy arc lengths. We present the utilityof fuzzy sets as arc length for TSP. An algorithmic technique based on geneticalgorithm is proposed for solving this fuzzy traveling salesman problem. Wehave designed a new crossover and mutation our proposed GA. We have useda numerical example to describe the effectiveness of our proposed algorithm.
Lightweight Traffic Sign Detection using Detachable Onboard Cameras
Authors: de Paula Mauricio , Jung Claudio 
Published: January 2023

Abstract
This paper presents a novel approach for traffic sign recognition (TSR) using off-the-shelf onboard vehicular cameras. Assuming that the camera intrinsic parameters are obtained offline, an online calibration scheme is used to estimate the extrinsic camera parameters, and Regions of Interest (ROIs) are created in the image domain based on the expected geometry and location of the traffic signs. Within theseROIs, the scale variation of the sign and background complexity are limited, allowing the development of lightweight Convolutional Neural Networks (CNNs) for TSR. Our experimental results for Brazilian traffic signs indicate that the proposed approach presents better accuracy than state-of-the-art methods at faster running times.
WITHDRAWN: Bio-modulation of poly (vinyl alcohol) crosslinked by silver and gold nanoparticles via laser ablation for wound healing utilization
Authors: Farea M. O. , Menazea Abdelrhman A. 
Published: January 2023

Abstract
This study aims to bio-modulate Poly (vinyl alcohol) crosslinked by silver and gold nanoparticles fabricated via one-step laser ablation. The structural, optical, and antibacterial properties of the fabricated samples were investigated via different techniques. FTIR and XRD were used to investigate the molecular structures of the polymer matrix of Polyvinyl Alcohol incorporating gold and silver (Ag-Au NPs) created by laser ablation. XRD data illustrate the semicrystalline structure of PVA, with two hump peaks at 2θ = 8.52o and 2θ = 20.17o that are decreased when loaded with Ag-Au nanoparticles at different laser ablation times. The FT-IR spectra demonstrated a variation in the intensity of various peaks compared to the spectrum of the Polyvinyl Alcohol. This suggests that PVA and Ag-Au nanoparticles interacted and complexed in semicrystalline areas. The optical energy gap (Eg) reduces from 5.55 eV to 5.00 eV during the direct transition and from 4.79 eV to 3.10 eV during the indirect transition. The cell viability value for sample S2 was 91.7 ± 5.8%, indicating that both nanocomposites are biocompatible. The values of S2, indicate that both nanocomposites are biocompatible. S2 represents the high values of the inhibition zone, which make it preferred in antibacterial applications. The results demonstrate that Polyvinyl Alcohol/metal composite materials have excellent optical and electrical properties, implying that they may be employed in energy devices.
Characterization of the complete chloroplast genome of Syringa oblata Lindl. from China and analysis of genome structures, comparative, phylogenetic relationships
Authors: Li Jing , Bai Ji-Qing , Du Shao-Bing , Meng Yi , Zhao Yi-Jun , Zhou Hui Hui , Xue Zhi-Peng , Wang Xiao-Ping , Wang Ping , Li Huai-Zhu 
Published: January 2023

Abstract
Syringa oblata is a flowering tree endemic to China, which has high medicinal and economic value. Comparative genomic analysis is necessary to elucidate the variation and phylogenetic relationships among Syringa species. An Illumina NovaSeq 6000 sequencing platform was used to sequence the whole genome of Syringa oblata plastomes in this study, and sequence assembly, annotation and characterization were performed by bioinformatics analysis, and a phylogenetic tree using Maximum Likelihood (ML) was constructed. A total of 155,668 bp was contained in the genome, which comprised two inverted repeats (IR) of 25,733 bp each, separated by a small single copy (SSC) region of 17,926 bp and a large single copy (LSC) region of 86 bp. There is a total GC content of 37.9% in the chloroplast genome, while the GC content in each region of SSC, LSC, and IR is 36.0%, 32.1%, and 43.2%. The genome contains 132 genes, including 88 protein-coding genes (CDS), 36 tRNA genes and 8 rRNA. There are seven protein-coding genes in the IR region, seven tRNA genes, and four rRNA genes. There was the most abundance of leucine and the least abundance of tryptophan among all amino acids. We detected 36 simple sequence repeats (SSRs) in the repeat structure analysis which included 32 mononucleotides (p1), 1 dinucleotide (p2), 1 trinucleotide (p3), 1 tetranucleotides (p4), and 1 complex nucleotide were explored, in the S. oblata chloroplast genome. In addition, we identified 50 long repeats, comprising 21 forward repeats, 28 palindromic repeats, and 1 complementary repeat. A phylogenetic analysis suggested that S. oblata (MW464119) is closely related to Syringa vulgaris (MG255768). It is anticipated that our results will be useful to further species identification, population genetic analysis, and biological research on Syringa oblata in the future.