bluuebunny/crossref_metadata_2025_split huggingface dataset:
How is depth of anaesthesia assessed in experimental pigs? A scoping review
Authors: Mirra Alessandro , Gamez Maidanskaia Ekaterina , Carmo Luís Pedro , Levionnois Olivier , Spadavecchia Claudia 
Published: March 2023

Background
Despite the large number of pigs involved in translational studies, no gold standard depth of anaesthesia indicators are available. We undertook a scoping review to investigate and summarize the evidence that sustains or contradicts the use of depth of anaesthesia indicators in this species.

Methods
Medline, Embase and CAB abstract were searched up to September 22nd 2022. No limits were set for time, language and study type. Only original articles of in vivo studies using pigs or minipigs undergoing general anaesthesia were included. The depth of anaesthesia indicators reported in the selected papers were divided in two categories: A, indicators purposely investigated as method to assess depth of anaesthesia; B, indicators reported but not investigated as method to assess depth of anaesthesia.

Results
Out of 13792 papers found, 105 were included after the screening process. Category A: 17 depth of anaesthesia indicators were found in 19 papers. Studies were conducted using inhalant anaesthetics as the main anaesthetic agent in the majority of the cases (13/19 = 68.4%), while 3/19 (15.8%) used propofol. The most investigated depth of anaesthesia indicators were bispectral index (8/19 = 42.1%) and spectral edge frequency 95% (5/19 = 26.3%). Contrasting results about the specific usefulness of each depth of anaesthesia indicators were reported. Category B: 23 depth of anaesthesia indicators were found in 92 papers. The most reported depth of anaesthesia indicators were: motor response following a stimulus (37/92 = 40.2%), depth of anaesthesia scores (21/92 = 23.3%), bispectral index (16/92 = 17.8%) and spectral edge frequency 95% (9/92 = 9.8%).

Conclusion
Results highlight the lack of scientifically valid and reliable indicators to ensure adequate depth of anaesthesia in pigs.
Malignant Pericardial Effusion due to Colorectal Cancer in a Young Man
Authors: Kaur Authors Avleen , Iqbal Sadat , Pittman Meredith E. , Lee Linda 
Published: March 2023

ABSTRACT
A 28-year-old man presented with sudden-onset right lower quadrant abdominal pain and shortness of breath at rest. On examination, he had tachycardia with distant heart sounds and right lower quadrant tenderness. A computed tomography scan showed segmental thickening of the proximal ascending colon and ileum with proximal cecal distension. Echocardiogram confirmed large pericardial effusion with impending tamponade. Video-assisted thoracoscopic surgery was performed for pericardial fluid drainage from a pericardial window. The mediastinal lymph node biopsy revealed metastatic adenocarcinoma cells. A colonoscopy showed a large polypoidal mass in the ascending colon with biopsy confirming poorly differentiated adenocarcinoma, thereby suggesting a possible lymphatic or hematogenous spread without liver or lung involvement.
Mapas de atención para destacar pólipos potenciales durante la colonoscopia
Authors: Martínez Carrillo Fabio , Ruiz García Lina Marcela , Guayacan Chaparro Luis Carlos 
Published: March 2023

Contexto: Los pólipos son masas protuberantes que crecen a lo largo del tracto intestinal y se consideran los principales precursores del cáncer de colon. En las etapas tempranas, la detección de pólipos representa una probabilidad de supervivencia de hasta el 93%, mientras que, en otras etapas, esta probabilidad disminuye hasta el 8%. A pesar de que la colonoscopia es el método más efectivo para detectar pólipos, varios estudios han demostrado una tasa de pérdida de hasta el 26% en la detección pólipos. Las herramientas computacionales han surgido como una alternativa para soportar la detección y localización de pólipos, pero varios problemas siguen abiertos debido a la alta variabilidad de los mismos.
Método: Este trabajo introduce una estrategia computacional que produce mapas de atención visual con la localización más probable de los pólipos para generar alarmas y apoyar la tarea de detección. Cada fotograma de colonoscopia se descompone en un conjunto de características profundas extraídas de arquitecturas preentrenadas. Dichas características se codifican en una representación densa de Hough para obtener una plantilla del pólipo, que posteriormente se propaga en cada fotograma para obtener los mapas de atención visual. Las regiones máximas son proyectadas a la colonoscopia para dibujar las regiones sospechosas de pólipo.
Resultados: La estrategia propuesta fue evaluada en los conjuntos de datos ASU-Mayo Clinic y CVC-Video Clinic, reportando una exactitud de 70% de detección entre las cuatro regiones más probables, mientras que con diez regiones se tiene un 80%.
Conclusiones: Los mapas de atención obtenidos destacan las regiones más probables con pólipos. El enfoque propuesto puede ser útil para apoyar el análisis de la colonoscopia.
„Polska Flota Napowietrzna” (1919–1921) – charakterystyka zawartości oraz formy edytorskiej czasopisma
Authors: Jazdon Grzegorz 
Published: March 2023

Mało znanym faktem związanym z powstaniem wielkopolskim jest istnienie trzech czasopism wydawanych przez agendy Wojsk Wielkopolskich. W niniejszym artykule możliwie szeroko została przedstawiona analiza lotniczego pisma „Polska Flota Napowietrzna”, ze szczególnym uwzględnieniem tematyki związanej z jego szatą ilustracyjną i zastosowanymi rozwiązaniami graficznymi. Przed 1919 rokiem cała historia polskiego czasopiśmiennictwa poświęconego aeronautyce obejmuje jedynie warszawskiego „Lotnika i Automobilistę” (1911–1914). Również lista wielkopolskich pism wojskowych w okresie walk o niepodległość nie jest zbyt rozbudowana, oprócz omawianego periodyku wydawane były jedynie: „Druh” (1918–1919), „Ku Chwale Ojczyzny” (1919–1920) i „Wiedza Techniczna” (1919–1920). „Polska Flota Napowietrzna” była wydawana od sierpnia 1919 do czerwca 1921 roku. Czasopismo było kierowane nie tylko do wojskowych, ale też do wszystkich zainteresowanych tematyką nowoczesności i wynalazczości. W artykule zostaną omówione: częstotliwość wydawania pisma, przemiany tytułu i podtytułu, cena, objętość, lokalizacja redakcji, drukarnie i miejsca dystrybucji. Następnie zostaną przedstawieni najważniejsi autorzy „Polskiej Floty Napowietrznej” oraz struktura i tematyka czasopisma. Całość zamyka analiza aspektów graficznych: papieru, podstawowej makiety pisma, używanych czcionek, okładek periodyku, zdjęć i ilustracji oraz ozdobników i szlaków drukarskich.
Realizacja polityki otwartego dostępu na przykładzie Uniwersytetu Jagiellońskiego w Krakowie
Authors: Szafrański Leszek 
Published: March 2023

Celem badań opisanych w artykule było przedstawienie doświadczeń pracowników Biblioteki Jagiellońskiej związanych z wdrażaniem polityki otwartego dostępu na Uniwersytecie Jagiellońskim. Opisane działania skupiają się zarówno na historycznym aspekcie wdrażania polityki, jak i na działaniach kontynuowanych lub podjętych po ogłoszeniu związanych z tym aktów prawnych. Do zbierania danych zostały wykorzystane metody analizy i krytyki piśmiennictwa oraz studium przypadku, których zastosowanie pozwoliło szczegółowo opisać temat otwartego dostępu do nauki z perspektywy wdrożenia takiej polityki na Uniwersytecie Jagiellońskim. Na kanwie zgromadzonych doświadczeń można stwierdzić, że główne problemy we wdrażaniu otwartej nauki na uczelni to słaba znajomość tematu przez pracowników i brak dostatecznego finansowania. Do głównych zalet natomiast należą: nieograniczony dostęp oraz szersze rozpowszechnienie wyników badań i publikacji naukowych.
Evaluation studies of the new mining projects
Authors: Al-Bakri Ali Y. , Ahmed Hussin A. M. , Ahmed Haitham M. , Hefni Mohammed A. 
Published: March 2023

Abstract
Mining still plays a vital role in providing various sectors with essential materials since many industries depend heavily on mined minerals. Moreover, the mining industry is the primary driver for many economies worldwide. On the other hand, new mining projects face many challenges, the most important of which are risks related to the economic aspects, e.g., the significant uncertainty about mineral resources compared to other engineering projects. Therefore, many jurisdictions worldwide depend on detailed engineering studies conducted according to internationally recognized standards to assess the new mining projects from an economic and technical perspective. In the same context and due to the significant lack of published research in this field, as the literature review revealed, this article reviewed and discussed the different main stages of engineering studies to evaluate new potential mining projects, including scoping, pre-feasibility, and feasibility studies, to ensure that the engineering study report complies with all the recognized main requirements. Results indicated the necessity of adhering to the needs of the engineering tasks while preparing reports of evaluation studies for new mining projects to reduce potential uncertainty risks and thus raise the level of confidence in these types of projects. Furthermore, they showed direct progress between the investigation details conducted in the evaluation studies and the value of the new mining project.
Identifying elevated plasma free triiodothyronine levels: age-adapted reference intervals for pediatrics
Authors: Janot Clément , Perrin Pauline , Bretones Patricia , Plotton Ingrid , Roucher-Boulez Florence , des Portes Vincent , Raverot Véronique 
Published: March 2023

Abstract

Objectives
Elevated free T3 (FT3) is an important feature for the early diagnosis of several diseases among which Grave’s disease or Allan-Hernon-Dudley syndrome. However, there is a lack of age-adapted reference intervals for plasma thyroid hormones in children. We conducted a study to define reference values of peripheral FT3 in children using a commonly used automated immunoassay.

Methods
All thyroid function test (TFT) results from our lab collected during 9 months were extracted anonymously, and reference intervals establishment followed recommendations validated by International Federation of Clinical Chemistry (IFCC).

Results
We defined five reference intervals covering the whole pediatric period. Overall, 26.1% of peripheral FT3 measured in children with normal TSH are out of the adult reference range, and 22.2% are upper it leading to misinterpretation. In a 9-month old patient with severe neurodevelopmental disorders, a pathological elevated FT3 has been securely interpreted using the newly established interval.

Conclusions
The study highlights the poor relevance of adult intervals in pediatric cares, as it confirms that plasmatic FT3 is higher during the whole pediatric period. This work reports useful age-adapted reference intervals for free T3 in pediatrics using a widely used electrochemiluminescent Immunoassay (ECLIA) kit.
A chiral microchip laser using anisotropic grating mirrors for single mode emission
Authors: Li Fangfang , Lapointe Shawn , Courval Théo , Fetisova Marina , Kämpfe Thomas , Verrier Isabelle , Jourlin Yves , Karvinen Petri , Kuittinen Markku , Bisson Jean-François 
Published: March 2023

Abstract
A pair of nanostructured mirrors made of a diffraction grating inscribed in the top layer of a Bragg mirror are designed such that a phase shift near π and different reflected amplitudes exist between transverse electric (TE) and magnetic (TM) reflected polarization states at normal incidence. When a standing wave laser resonator is formed with two such mirrors and the two mirrors’ principal axes are twisted one with respect to the other, this phase shift condition suppresses multiple longitudinal mode emission arising from axial spatial hole burning. In addition, the different amplitudes of TE and TM reflected polarizations create polarization eigenstates with different round-trip losses, suppressing one polarization eigenstate. Laser experiments made with a Yb3+-doped Y3Al5O12 active material reveal enhanced purity of the emission spectrum compared to similar lasers using conventional laser mirrors. The proposed design enables a miniature single mode laser, replacing more complex designs usually needed to achieve that goal.
Crystal structure of E-7-fluoro-2-(2-(trifluoromethyl)benzylidene)-3,4-dihydronaphthalen-1(2H)-one, C18H12F4O
Authors: Zhang Juan , Hou Yun , Zhao Feng-Lan , Meng Qing-Guo 
Published: March 2023

Abstract
C18H12F4O, triclinic, P1̄ (no. 2), a = 7.9400(8) Å, b = 8.1071(9) Å, c = 13.3238(15) Å, α =

89.394

(
9
)

°

$89.394\left(9\right)^{\circ} $

, β =

76.343

(
9
)

°

$76.343\left(9\right)^{\circ} $

, γ

$$

=

63.411

(
11
)

°

$\text{63.411}\left(11\right)^{\circ} $

, V = 740.79(15) Å3, Z = 2,

R

g
t

${R}_{\mathit{g}\mathit{t}}$

(F) = 0.0472,

w

R

r
e
f

$w{R}_{\mathit{r}\mathit{e}\mathit{f}}$

(F
2) = 0.1244, T = 293 K.
The crystal structure of 4-(4-iodophenyl)-5H-1,2,3-dithiazole-5-thione, C8H4INS3
Authors: Liao Huiyang , Ni Penghui 
Published: March 2023

Abstract
C8H4INS3, monoclinic, P21/c (no. 14), a = 11.8060(19) Å, b = 7.8961(14) Å, c = 11.972(2) Å, β =

110.981

(
2
)

°

$110.981(2){}^{\circ}$

, V = 1042.1(3) Å3, Z = 4, R

gt
(F) = 0.0279, wR

ref
(F
2) = 0.0739, T = 296(2) K.
Latmos: a semiotic view on the subject’s role in the sustainability of natural and cultural values
Authors: Kalelioğlu Murat 
Published: March 2023

Abstract
Along with the developments in social, scientific, and technological fields, today’s conditions are constantly changing and becoming much more complex. Humans must keep pace with the rapidly changing world, meet requirements, and solve various problems encountered with minimal damage. One of the most crucial obligations is to preserve the delicate balance between nature and culture to make it sustainable for humanity. This study is carried out pursuant to semiotics with an interdisciplinary perspective dealing with the relation of culture with nature and the role of humans, as a subject, in this relation regarding both natural and cultural heritages of Latmos. The study examines the subject’s acts and possible influences on nature, culture, and society in the region. It is seen that there is an uphill battle between two different subjects; the reason for this is a conflict of interest encountered on individual and social planes. On the one hand, one of the subjects is aware of the positive effects of preserving natural and cultural values on society and its future. On the other hand, another subject is unaware of all these or is aware of them but ignores natural and cultural values and destroys them for the sake of self-interest.
National Strength and Conditioning Association Position Statement on Weightlifting for Sports Performance
Authors: Comfort Paul , Haff G. Gregory , Suchomel Timothy J. , Soriano Marcos A. , Pierce Kyle C. , Hornsby W. Guy , Haff Erin E. , Sommerfield Lesley M. , Chavda Shyam , Morris Stephanie J. , Fry Andrew C. , Stone Michael H. 
Published: March 2023

Abstract
Comfort, P, Haff, GG, Suchomel, TJ, Soriano, MA, Pierce, KC, Hornsby, WG, Haff, EE, Sommerfield, LM, Chavda, S, Morris, SJ, Fry, AC, and Stone, MH. National Strength and Conditioning Association position statement on weightlifting for sports performance. J Strength Cond Res 37(6): 1163–1190, 2023—The origins of weightlifting and feats of strength span back to ancient Egypt, China, and Greece, with the introduction of weightlifting into the Olympic Games in 1896. However, it was not until the 1950s that training based on weightlifting was adopted by strength coaches working with team sports and athletics, with weightlifting research in peer-reviewed journals becoming prominent since the 1970s. Over the past few decades, researchers have focused on the use of weightlifting-based training to enhance performance in nonweightlifters because of the biomechanical similarities (e.g., rapid forceful extension of the hips, knees, and ankles) associated with the second pull phase of the clean and snatch, the drive/thrust phase of the jerk and athletic tasks such as jumping and sprinting. The highest force, rate of force development, and power outputs have been reported during such movements, highlighting the potential for such tasks to enhance these key physical qualities in athletes. In addition, the ability to manipulate barbell load across the extensive range of weightlifting exercises and their derivatives permits the strength and conditioning coach the opportunity to emphasize the development of strength-speed and speed-strength, as required for the individual athlete. As such, the results of numerous longitudinal studies and subsequent meta-analyses demonstrate the inclusion of weightlifting exercises into strength and conditioning programs results in greater improvements in force-production characteristics and performance in athletic tasks than general resistance training or plyometric training alone. However, it is essential that such exercises are appropriately programmed adopting a sequential approach across training blocks (including exercise variation, loads, and volumes) to ensure the desired adaptations, whereas strength and conditioning coaches emphasize appropriate technique and skill development of athletes performing such exercises.
The cell cycle and cell size influence the rates of global cellular translation and transcription in fission yeast
Authors: Basier Clovis , Nurse Paul 
Published: March 2023

AbstractHow the production of biomass is controlled as cells increase in size and proceed through the cell cycle events is important for understanding the regulation of global cellular growth. This has been studied for decades but has not yielded consistent results, probably due to perturbations induced by the synchronisation methods used in most previous studies. To avoid this problem, we have developed a system to analyse unperturbed exponentially growing populations of fission yeast cells. We generated thousands of fixed single‐cell measurements of cell size, cell cycle stage and the levels of global cellular translation and transcription. We show that translation scales with size, and additionally, increases at late S‐phase/early G2 and early in mitosis and decreases later in mitosis, suggesting that cell cycle controls are also operative over global cellular translation. Transcription increases with both size and the amount of DNA, suggesting that the level of transcription of a cell may be the result of a dynamic equilibrium between the number of RNA polymerases associating and disassociating from DNA.
Serum anti-Müllerian hormone (AMH) concentration during pregnancy: a longitudinal study
Authors: McCredie Sarah , An Belinda , McShane Monika , Ledger William , Venetis Christos A 
Published: March 2023

A prospective longitudinal cohort study aimed to longitudinally examine the kinetics of anti-Müllerian hormone (AMH) during the first two trimesters of pregnancy. Pregnant women with stored first-trimester serum samples were recruited at 24–28 weeks gestation during their gestational diabetes testing, where they provided an additional serum sample. The samples were analysed for AMH, oestradiol and progesterone concentrations. A decrease in serum AMH was observed in 40 out of 45 (88.9%) (95% CI: 75.9–96.3%) of the participants in this study. The median serum AMH concentration was 10.9 pmol/L in the first trimester and 6.5 pmol/L during the second trimester, with a significantly different distribution of the values between the first-trimester and the second-trimester AMH samples (P < 0.001). The median percentage of AMH difference of −39.8%. This study demonstrated a significant decrease in serum AMH levels from the first to the second trimester of pregnancy. The absolute decrease in AMH levels seems to be positively associated with first-trimester AMH levels, whereas the percentage of AMH difference is not. Further studies are required to elucidate the potential physiological mechanisms of this finding.

Lay summary
Anti-Müllerian hormone, also known as AMH, is produced by developing ovarian follicles in the ovary. The concentration of AMH in the serum is used as a marker of ovarian reserve. This marker has been shown to vary throughout the menstrual cycle and in women using hormonal contraception. This study examined this marker in women in the first and second trimesters of pregnancy to determine if it is variable throughout pregnancy. The study found that there was a significant decrease from the first to second trimester, with a larger decrease seen in women who had a higher first-trimester concentration of this marker. Further research is required to determine the physiological mechanism which causes the reduction of AMH in pregnancy.
Mortality and Cause of Death in Children With Presumptive Disseminated Tuberculosis
Authors: Bonnet Maryline , Nordholm Anne-Christine , Ssekyanzi Bob , Byamukama Onesmus , Orikiriza Patrick , Tusabe Tobias , Nyehangane Dan , Taremwa Ivan Mugisha , Turyashemererwa Esther , Wobudeya Eric , Mwanga-Amumpaire Juliet , Marais Ben J , Nampijja Dorah 
Published: March 2023

BACKGROUND AND OBJECTIVES
Children experience high tuberculosis (TB)-related mortality but causes of death among those with presumptive TB are poorly documented. We describe the mortality, likely causes of death, and associated risk factors among vulnerable children admitted with presumptive TB in rural Uganda.

METHODS
We conducted a prospective study of vulnerable children, defined as &lt;2 years of age, HIV-positive, or severely malnourished, with a clinical suspicion of TB. Children were assessed for TB and followed for 24 weeks. TB classification and likely cause of death were assessed by an expert endpoint review committee, including insight gained from minimally invasive autopsies, when possible.

RESULTS
Of the 219 children included, 157 (71.7%) were &lt;2 years of age, 72 (32.9%) were HIV-positive, and 184 (84.0%) were severely malnourished. Seventy-one (32.4%) were classified as “likely tuberculosis” (15 confirmed and 56 unconfirmed), and 72 (32.9%) died. The median time to death was 12 days. The most frequent causes of death, ascertained for 59 children (81.9%), including 23 cases with autopsy results, were severe pneumonia excluding confirmed TB (23.7%), hypovolemic shock due to diarrhea (20.3%), cardiac failure (13.6%), severe sepsis (13.6%), and confirmed TB (10.2%). Mortality risk factors were confirmed TB (adjusted hazard ratio [aHR] = 2.84 [95% confidence interval (CI): 1.19–6.77]), being HIV-positive (aHR = 2.45 [95% CI: 1.37–4.38]), and severe clinical state on admission (aHR = 2.45 [95% CI: 1.29–4.66]).

CONCLUSIONS
Vulnerable children hospitalized with presumptive TB experienced high mortality. A better understanding of the likely causes of death in this group is important to guide empirical management.