bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neurogenic pulmonary edema and Takotsubo cardiomyopathy in aneurysmal subarachnoid hemorrhage
Authors: Hwang Eui-Hyun , Koo Ja Ho , Lee Yeonhu , Song Ji Hye , Lim Yong Cheol 
Published: April 2023

Abstract
Objective: Neurogenic pulmonary edema (NPE) combined with Takotsubo cardiomyopathy (TCM) is a unique condition associated with aneurysmal subarachnoid hemorrhage (aSAH). Although several mechanisms have been proposed, the pathophysiology and management strategies are not yet fully established. We aimed to determine the radiological and clinical outcome of patients with NPE with TCM after aSAH and to propose management strategies.
Methods: We analyzed the data of 573 patients with aSAH recorded at a single medical center from February 2015 to July 2022. This study retrospectively investigated the incidence and demographics of SAH combined with both NPE and TCM and the clinical outcomes of the patients. Risk factors of NPE-TCM were also investigated.
Results: During the 7 years, 11 (1.9%) of 513 patients had NPE complicated with TCM after aSAH. All 11 patients had poor-grade SAH (Hunt–Hess Grade 3 to 5). Three of 11 patients had posterior circulation in the NPE-TCM group. The most prevalent treatment option was endovascular coil embolization except for one case of clip. Long-term outcomes were favorable in 6 of 11 patients, and there was one case of mortality. Age, troponin I level, and alveolar-arterial oxygen gradient were risk factors of NPE-TCM.
Conclusion: NPE combined with TCM is a unique finding in patients with aSAH, and severe clinical conditions may be independent predictors of a fatal outcome. Therefore, understanding the pathophysiology and appropriate management of this condition can improve outcome in patients with aSAH.
Use of Video-Assisted Thoracoscopy in the Treatment of Primary Spontaneous Pneumothorax in Children
Authors: Şahin Ceyhan , Ayyıldız H. Nihan Karaman , Mirapoğlu Semih , Güvenç F. Tuğba , Yıldız Zeliha Akış , Arpacık Mehmet , Kaymakçı Aytekin , İlçe Zekeriya 
Published: April 2023

Abstract
Purpose:This study aims to review the Primer Spontan Pneumothorax (PSP) patients we have treated as well as the literature and to present our approach to the treatment of PSP in pediatric patients and Video-Assisted Thoracoscopic Surgery (VATS).
Methods:The study was designed retrospectively and conducted at a tertiary referral university hospital between January 1, 2015 and May 1, 2021. Patients under the age of 18 years with a diagnosis of Pneumothorax (PTX) were included in the study. Medical records were analyzed in terms of clinical characteristics, demographic data, findings from imaging data, procedures performed, and course of the disease at hospital. Patients with no evidence of PTX on radiologic imaging (direct posteroanterior chest X-ray (PA CXR) or Thoracic computed tomography (CT)), incomplete medical records for follow-up, history of trauma, and neonatal pneumothorax were excluded from the study.
Results:
The study was conducted on a total of 98 PTX cases in 69 patients, 61 (88.4%) males and 8 (11.6%) females. The ages of the patients ranged between 13 and 17 years with a mean of 16.59 ± 0.95 years. While 48 (49%) PTX cases were treated with tube thoracostomy, 19 (19.4%) were treated with medical follow-up and 31 (31.6%) were treated with VATS. A total of 31 VATS procedures were performed in 28 patients. The follow-up period after VATS ranged from 3 to 78 months, with a mean of 31.5 ± 20.3 months and a median of 28 months.
Conclusion:If PSP is detected on PA CXR in a pediatric patient presenting with chest pain and respiratory distress, there is no need for CT scan. CT can be performed in recurrent PTX and in patients undergoing surgery. If the percentage of PTX detected in PA CXR is below 32%, medical follow-up should be applied, if it is above 32%, tube thoracostomy should be applied, and if it is above 72%, the patient should be considered as a candidate for VATS. If there is no decrease in O2 sat during medical monitoring, there is no need for additional O2 supplementation. If PTX does not start to shrink and lung expansion does not increase 60 hours after the start of medical follow-up and if PTX is progressive during follow-up, tube thoracostomy should be performed. VATS should be performed if there is no increase in lung expansion 18 hours after tube thoracostomy, if the pneumothorax is progressive, and if air leaks persist for more than 10 days despite increased lung expansion and if recurrent pneumothorax occurs. If pleurectomy is to be performed during VATS, partial pleurectomy should be preferred.
Risk Assessment of Mounded Storage Tanks
Authors: Du Chenyang , Liu Chang , Yuan Jun , Cheng Xin , Song Ce , Li Xiaowei 
Published: April 2023

Abstract
The Mounded Vessel is the third form different from the above ground and buried storage containers. In this paper, qualitative and quantitative assessment methods are comprehensively used for risk assessment of Mounded Vessel. Quantitative calculation method is used for failure probability, and qualitative calculation method is used for failure consequence. By comparing and evaluating the risk level of propylene Mounded Vessel and above ground propylene spherical tanks with similar parameters, it is concluded that the failure consequences of Mounded Vessel are smaller, the risk level is lower, and the safety is higher.
Touraine-Solente-Gole syndrome: pathogenic variant in SLCO2A1 presented with polyarthralgia and digital clubbing
Authors: Nicolau Rafaela , Beirão Tiago Melo , Guimarães Franscisca , Aguiar Francisca , Ganhão Sara , Rodrigues Mariana , Grangeia Ana , Brito Iva 
Published: April 2023

Abstract
Background: Primary Hypertrophic Osteoarthropathy (PHO), also known as Touraine-Solente-Gole Syndrome, is a rare, multisystemic autosomal recessive disorder caused by pathogenic variants in the HPGD or SLCO2A1 genes. However, autosomal dominant transmission has also been described in some families with incomplete penetrance. PHO usually starts in childhood or adolescence, presenting with digital clubbing, osteoarthropathy, and pachydermia. We described a complete form of the syndrome in a male patient with a homozygous variant in the SLCO2A1 gene (c.1259G>T).
Case presentation: A 20-year-old male was referred to our Pediatric Rheumatology Clinic with a five-year history of painful and swollen hands, knees, ankles and feet, prolonged morning stiffness and relief with non-steroidal antiinflammatory drugs. He also reported late onset facial acne and palmoplantar hyperhidrosis. Family history was irrelevant and parents were non-consanguineous. On clinical examination, he presented clubbing of the fingers and toes, moderate acne and marked facial skin thickening with prominent scalp folds. He had hand, knee, ankles and feet swelling. Laboratory investigation showed elevated inflammatory markers. Complete blood count, renal and hepatic function, bone biochemistry were normal, as well as immunological panel. Plain radiographs revealed soft tissue swelling, periosteal ossification and cortical thickening of the skull, phalanges, femur and toe acroosteolysis. Due to the absence of other clinical signs suggesting a secondary cause, we suspected PHO. A genetic study revealed a likely pathogenic variant, c.1259G>T (p.Cys420Phe), in homozygosity in the SLCO2A1 gene, thus confirming the diagnosis. The patient started oral naproxen with significant clinical improvement.
Conclusions: PHO should be kept in the differential diagnosis of inflammatory arthritis affecting children, most of the times misdiagnosed as Juvenile Idiopathic Arthritis (JIA). To the best of our knowledge, this is the first reported case of this pathogenic variant and it constitutes the second genetically confirmed case of PHO in a Portuguese patient (first variant c.644C >T), both made at our department.
Development of the Burnishing Process: Moving Towards Increasing the Quality and Surface Hardness of Aluminum alloy 2024
Authors: Najafabadi Akbar Hojjati 
Published: April 2023

Abstract
Because of the hard grind of some metals such as aluminum, copper and brass, burnishing can be very effective. Burnishing is a non-cutting process in which the surface of the workpiece is plastically deformed by hard work and pressure in the surface layers of the workpiece. In this study, the burnishing process is applied to 2024 aluminum alloy to improve the quality of the final surface and its increasing hardness. In this process, a roller-based tool was used for burnishing with the lathe. The parameters of spindle speed, feed rate and burnishing force were used in three stages, with two repetition phases and in the full factorial method in aluminum 2024 burnishing. Minitab software was used to determine the effects of the different parameters on surface roughness and hardness. Also, the regression method was used to predict the surface roughness and hardness under the influence of the parameters. The results showed that the optimum surface roughness (Ra = 0.05µm) was achieved at a feed rate of 0.11mm/rev, a spindle speed of 1000rpm, and a burnishing force of 1000N.
Childhood, adulthood, and cumulative traumatic events experienced from childhood to adulthood and dementia risk: a population-based cohort study
Authors: Xie Ziwei , Sun Huizi , Zhou Chunmiao , Fu Chunying , Wang Qi , Dong Caiyun , Hao Wenting , Zhen Xuemei , Zhu Dongshan 
Published: April 2023

Abstract
Objective
We aim to examine the associations of traumatic events experienced in childhood, adulthood, and cumulative traumatic events experienced from childhood to adulthood, with risk of all-cause dementia, including Alzheimer's disease (AD) and vascular dementia (VD), whilst considering the roles of sex.
Methods
We used data from the UK Biobank cohort study and 145,558 participants were included. Frequency of traumatic events (including emotional abuse, physical abuse, and sexual abuse) experienced in childhood and adulthood were collected. Cumulative number and type of traumatic events experienced from childhood to adulthood were also calculated. We used cox proportional hazards models to estimate hazard ratios (HRs) and 95% confidence intervals (CI) for the association between traumatic events and risk of all-cause dementia. Sex-specific associations were also analyzed.
Results
Compared to people who did not experience traumatic events in their life course, those who often experienced emotional, physical, and sexual abuse in childhood were associated with a higher risk of all-cause dementia, with HRs (95% CI) of 2.23 (1.34, 3.71), 3.16 (1.81, 5.53) and 3.23 (1.52, 6.89), respectively. Corresponding HRs (95% CI) in people who experienced traumatic events in adulthood were 1.42 (1.11, 1.82), 1.96 (0.97, 3.98), and 3.13 (1.18, 8.27), respectively. After cumulative type of traumatic events were calculated from childhood to adulthood, we found that people who experienced both emotional and physical abuse in childhood had the highest risk of all-cause dementia in later life with HRs (95% CI) of 1.94 (1.00-3.78).
Conclusions
Both traumatic events experienced in childhood and adulthood were related to an increased risk of dementia. People who experienced both emotional and physical abuse in childhood had the highest risk of all-cause dementia.
A Proposal to Teach Medical Students How to Use Interpreters
Authors: Thomas Kyle , Jacobs Nicole , Silva Lizette , Teixeira Amir , Andrade Alejandro , Vera Alexandra Lopez 
Published: April 2023

Abstract
The necessity of trained medical interpreters is crucial to ensure fair and high-quality healthcare for patients with limited English proficiency. Despite this requirement, medical schools often do not adequately educate their students on how to work with interpreters. This study outlines a curriculum developed to tackle the deficiency of interpreter-use training for medical students. The interactive model used in the curriculum enabled students to practice patient interactions with interpreters and learn about the ethical, cultural, and legal aspects of interpreter use. Post-workshop surveys were conducted to determine student readiness for future clinical experiences that require the use of a medical interpreter. The effectiveness of the curriculum was confirmed in preparing students for interpreter use. The study's objective is to reduce healthcare disparities by training students to navigate cultural and linguistic barriers between themselves, limited English proficiency patients, and interpreters. By providing early training to medical students, they will be equipped to interact with limited English proficiency patients not only during clinical rotations but also throughout their medical careers. The study underscores the significance of incorporating language-discordant encounters with interpreters and corresponding health equity curricula in medical schools.
Rebound multi-system inflammatory syndrome in children (MIS-C): A case report of an extremely rare phenomenon
Authors: Alyasin Soheila Sadat , Johari Leila , Noeiaghdam Rafat , Moshfeghinia Reza , Mehdizadegan Nima 
Published: April 2023

Abstract
Background: Multi-system inflammatory syndrome in children (MIS-C) is a newly defined clinical syndrome characterized by systemic inflammation, fever, and multi-organ dysfunction related to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. While MIS-C is familiar to most physicians, recurrent and rebound cases of MIS-C are extremely rare, with only two such cases reported to date.
Case presentation: Here, we report the case of a five-month-old boy diagnosed with rebound MIS-C (19 days apart), with the second episode being more severe and featuring a right coronary artery aneurysm. The immunodeficiency workup returned normal. Standard MIS-C treatment protocols were followed in both episodes, eventually yielding an excellent outcome. The patient remained well within 12 months of follow-up.
Conclusions: We conclude that longer and closer follow-ups of MIS-C patients may be needed, perhaps with a more aggressive treatment protocol to prevent a rebound or recurrence of the disease, though further studies are required to guide clinical decision-making.
A Symmetrical High Utilization Rate of Physical Sensors Array for Passive Direction Finding of Mixed Near-Field and Far-Field Signals
Authors: Du Bo , Cui Weijia , Jian Chunxiao , Du Yuxi , Lin Wei 
Published: April 2023

Abstract
Direction of arrival (DOA) estimation is an important branch in the field of array signal processing. In the research field of DOA estimation of mixed near-field (NF) and farfield (FF) signals, the traditional uniform linear arrays (ULAs) and sparse linear arrays (SLAs) have low utilization rate of physical array sensors and low degrees of freedom. For the purpose of improving the utilization rate of physical array sensors and improving the passive direction finding performance, a configuration method named symmetrical high utilization rate of physical sensors array (SHUA) is proposed in this paper. High utilization means that, under the constraint of array size, SHUA can reduce the redundancy during the generation process of consecutive lags by maximizing the utilization of the physical sensors, thus generating more consecutive lags. This configuration method innovatively reduces the redundancy of consecutive lags and enlarges the array aperture by solving a local optimal solution under the performance conditions limited by the computer. More consecutive lags and larger array aperture allow for more accurate estimation of DOA and range parameters. Simulation experiments show that, under the restriction of the same array size, compared with the common sensor array configurations, the SHUA can make better use of the physical array sensors and upgrade the passive direction finding performance.
The prevalence of dental caries and associated risk factors in Chinese children aged 7-9 years
Authors: Li Hui , Liu Xiaoyu , Xu Jianhui , Li Siwei , Wang Xueqin , Li Xin 
Published: April 2023

Abstract
Background
Dental caries is the most common oral health problem in school-age children caused by the interaction of microorganisms, substrates and teeth over time. The objective of this study was to evaluate the prevalence, severity, oral distribution, and associated risk factors of deciduous tooth caries in children aged 7–9 years in Jinzhou, China.
Methods
A total of 1,603 primary school students aged 7–9 years old from public and private schools in Jinzhou were recruited using multi-stage, stratified, and random sampling methods for cross-sectional studies. Deciduous teeth caries in school-age children were detected and recorded according to the World Health Organization standard, and a questionnaire was collected from a parent or guardian with information on the relevant risk factors for the child. Odds ratios and 95% confidence intervals of caries-related factors were estimated using binary logistic regression analysis.
Results
The prevalence of deciduous tooth caries was 74.5%, the average caries was 3.02,and dmft was 4.08 ± 2.74.There were 655 cases (77.1%) of caries in boys and 539 cases (71.6%) in girls, and the difference between them has statistical significance (P < 0.05). Binary Logistic regression analysis showed that the mother's education level, flossing, reason for last dental visit, and consumption of desserts, sweets, and soft drinks were associated with the prevalence of dental caries.
Conclusions
Deciduous teeth have a high incidence of dental caries in children aged 7–9 years, especially mandibular deciduous molars are the most common. Social demographic factors, socioeconomic status factors, oral hygiene habits, and dietary habits all play an important role in the occurrence of dental caries.
SOCS3 expression in cutaneous lichen planus
Authors: Doss Reham William , El-Rifaie Abdel-Aziz , Rashed Laila Ahmed , Naguib Rehab 
Published: April 2023

Abstract
Background: Lichen Planus (LP) is an idiopathic, inflammatory, autoimmune disease. The aetiopathogenesis of LP is still unclear. Suppressor of cytokine signaling- 3 (SOCS3) is known to inhibit cytokine signaling through Janus kinase (JAK) /signal transducers, activators of transcription , NFkB, and focal adhesion kinase (FAK) signaling pathways. Modulation of SOCS3 level leads to immune dysfunction.
Aim of the work: Our study aimed to detect a possible role of SOCS3 in cutaneous LP
Methods: In this case - control study skin biopsies were collected from 30 LP patients and 30 healthy volunteers. Biopsies were kept in lysis solution frozen at -80 Celsius till analysis of SOCS3 using Real time polymerase chain technique (RT-PCR) was done.
Results: The expression of SOCS3 in cutaneous LP was significantly higher when compared to normal skin from healthy controls (p < 0.001).
Conclusion: SOCS3 might play a role in the pathogenesis of LP
Exploring the National Nursing Research Priorities in the Eastern Mediterranean Region and Overcoming Associated Challenges
Authors: Nashwan Abdulqadir J. , Hashish Ebtsam A. Abou , Mohamed Ahmed S. , Alrimawi Intima , Aqtam Ibrahim , Obeisat Salwa Al , Alhalaiqa Fadwa , Alzaatreh Mohammad , Alhadidi Majdi , AL-Fayyadh Sadeq , Faleh Jadeel N. , Shaban Marwa M. , Shaban Mostafa , Mirzaei Alireza , Vakilabad Reza N. , Arabloo Jalal , Siddique Sulman , Alharbi Hanan F. , Alshdefat Aisha , Atout Maha 
Published: April 2023

AbstractBackground Nurses play a significant role in contributing to various health priorities globally, including research. Identifying the status of national nursing research priorities (NNRPs) in the Eastern Mediterranean Region (EMR) is crucial to cultivate these priorities. Aim This paper aims to highlight the existing status of NNRPs in EMR countries concerning their existence and publicity. Methods Experts from nine EMR countries, including Egypt, Iran, Iraq, Jordan, Pakistan, Palestine, Qatar, Oman, and Saudi Arabia, responded, and participated in this report. The analysis was conducted to determine the percentage of countries with existing, under development, or nonexistent NNRPs. Results The analysis shows that 58% of the participating countries have existing NNRPs, while 25.8% don't and 16% are under development. The largest portion of NNRPs (38%) was developed by governmental organizations. Midwives were not specified in half of the published priorities. The majority of NNRPs (65%) were developed by experts’ opinions and consensus, and 33% only have an associated strategy, outcome measures, and funding opportunities. Yet, most of the published research priorities were not updated regularly. Conclusion EMR countries face a challenge with the need for more nurses, which may hinder their involvement in research projects or continued education. Despite this, all countries involved in this report emphasized the importance of developing nursing education and research as priorities for improving their current nursing workforce. Health policymakers, nurse practitioners, academic researchers, educators, and nursing leaders should collaborate to develop operational plans to foster national nursing education and research.
Risk factors associated with the initial unplanned removal of orogastric tubes in NICU: A Single Center Study in China
Authors: Chen Jun , Fang Xiaoling , Dai Yiheng , Liu Lijun , Huang Chaomei 
Published: April 2023

Abstract
Background: Newborns, in particular, are at higher risk for unplanned removal of orogastric tubes (UROGTs). Because there is a lack of studies identifying the incidence and risk factors for UROGTs in China, we designed this case‒control study to investigate them.
Method: This study was conducted in China. A total of 111 neonates who received orogastric tubes between October 2022 and February 2023 were analyzed. Univariate and multivariate logistic models were used for risk factor analyses.
Results: The rate of UROGTs was 56.8%, and the incidence was 7.2 per 100 tube days. An increased risk of UROGTs was associated with higher agitation scores (OR=17.82, P=0.001), no oral feeding (OR=0.02, P=0.007), fixation tape loosening (OR=22.75, P=0.027) and tape wetting (OR=12.6, P=0.021).
Conclusions: The incidence of UROGTs was found to be significantly higher than that of endotracheal tube extubation. The risk factors were higher agitation scores, no oral feeding, fixation tape loosening and tape wetting.
Analysis of rare Parkinson’s disease variants in millions of people
Authors: Pitz Vanessa , Makarious Mary , Bandrés-Ciga Sara , Iwaki Hirotaka , Singleton Andrew , Nalls Mike , Heilbron Karl , Blauwendraat Cornelis 
Published: April 2023

Abstract
Objective
Although many rare variants have been reportedly associated with Parkinson’s disease (PD), many have not been replicated or have failed to replicate. Here, we conduct a large-scale replication of rare PD variants.
Methods
We assessed a total of 27,590 PD cases, 6,701 PD proxies, and 3,106,080 controls from three data sets: 23andMe, Inc., UK Biobank, and AMP-PD. Based on well-known PD genes, 834 variants of interest were selected from the ClinVar annotated 23andMe dataset. We performed a meta-analysis using summary statistics of all three studies.
Results
The meta-analysis resulted in 11 significant variants after Bonferroni correction, including variants in GBA1 and LRRK2. At least 9 previously reported pathogenic or risk variants for PD did not pass Bonferroni correction in this analysis.
Conclusions
Here, we provide the largest rare variant meta-analysis to date, providing thorough information of variants confirmed, newly identified, or rebutted for their association with PD.