bluuebunny/crossref_metadata_2025_split huggingface dataset:
Macular, choroidal and disc associations across women’s reproductive life stages: a scoping review from menarche to post-menopause
Authors: Ribeiro Reis Ana Paula , Ioannidou Estelle , Stuart Kelsey V. , Wagner Siegfried K. , Foster Paul J. , Khawaja Anthony P. , Petzold Axel , Sivaprasad Sobha , Pontikos Nikolas , Keane Pearse A. , Balaskas Konstantinos , Patel Praveen J. 
Published: January 2025

Abstract
Oestrogen and progesterone fluctuate cyclically in women throughout their adult lives. Although these hormones cross the blood-retinal barrier and bind to intraocular receptors, their effects remain unclear. We present the first review to date on associations between posterior pole structures—specifically the macula, choroid, and optic disc—and both the menstrual cycle and post-menopausal period, utilising multimodal imaging techniques in healthy adult non-pregnant women. We excluded studies on contraception and hormonal replacement therapy, focusing solely on physiological associations. Despite the comprehensive scope of our review, limited data and inconsistent reporting among studies prevented the establishment of meaningful trends. Across menstrual cycle phases, choroidal thickness (CHT) was the most consistently reported parameter, with thinning during the luteal phase compared to the follicular phase. Conversely, no significant differences were observed in macular or disc morphology across the cycle, likely reflecting a preserved structure despite potential fluctuations in blood flow and perfusion. Studies comparing pre- and post-menopausal associations, after adjusting for age or body mass index (BMI), failed to reveal meaningful trends, highlighting the difficulty in separating the effect of age from hormonal declines in older women. Understanding how hormonal cycles impact the posterior pole in women is crucial for addressing sex differences in various ocular pathologies. Research on female-specific factors is still sparse, and interestingly, the majority of affiliations in the reviewed articles did not originate from regions with the highest biomedical research funding and publication rates. We encourage further studies focusing on female-specific variables and provide recommendations for future designs.
Long-term memory plasticity in a decade-long connectivity study post anterior temporal lobe resection
Authors: Fleury Marine N. , Binding Lawrence P. , Taylor Peter , Xiao Fenglai , Giampiccolo Davide , Buck Sarah , Winston Gavin P. , Thompson Pamela J. , Baxendale Sallie , McEvoy Andrew W. , Koepp Matthias J. , Duncan John S. , Sidhu Meneka K. 
Published: January 2025

Abstract
Approximately 40% of individuals undergoing anterior temporal lobe resection for temporal lobe epilepsy experience episodic memory decline. There has been a focus on early memory network changes; longer-term plasticity and its impact on memory function are unclear. Our study investigates neural mechanisms of memory recovery and network plasticity over nearly a decade post-surgery. We assess memory network changes, from 3–12 months to 10 years postoperatively, in 25 patients (12 left-sided resections) relative to 10 healthy matched controls, using longitudinal task-based functional MRI and standard neuropsychology assessments. We observe key adaptive changes in memory networks of a predominantly seizure-free cohort. Ongoing neuroplasticity in posterior medial temporal regions and contralesional cingulum or pallidum contribute to long-term verbal and visual memory recovery. Here, we show the potential for sustained cognitive improvement and importance of strategic approaches in epilepsy treatment, advocating for conservative surgeries and long-term use of cognitive rehabilitation for ongoing recovery.
Herpesviruses mimic zygotic genome activation to promote viral replication
Authors: Neugebauer Eva , Walter Stephanie , Tan Jiang , Drayman Nir , Franke Vedran , van Gent Michiel , Pennisi Sandra , Veratti Pia , Stein Karla S. , Welker Isabelle , Tay Savaş , Verjans Georges M. G. M. , Timmers H. T. Marc , Akalin Altuna , Landthaler Markus , Ensser Armin , Wyler Emanuel , Full Florian 
Published: January 2025

Abstract
Zygotic genome activation (ZGA) is crucial for maternal to zygotic transition at the 2-8-cell stage in order to overcome silencing of genes and enable transcription from the zygotic genome. In humans, ZGA is induced by DUX4, a pioneer factor that drives expression of downstream germline-specific genes and retroelements. Here we show that herpesviruses from all subfamilies, papillomaviruses and Merkel cell polyomavirus actively induce DUX4 expression to promote viral transcription and replication. Analysis of single-cell sequencing data sets from patients shows that viral DUX4 activation is of relevance in vivo. Herpes-simplex virus 1 (HSV-1) immediate early proteins directly induce expression of DUX4 and its target genes, which mimics zygotic genome activation. Upon HSV-1 infection, DUX4 directly binds to the viral genome and promotes viral transcription. DUX4 is functionally required for infection, since genetic depletion by CRISPR/Cas9 as well as degradation of DUX4 by nanobody constructs abrogates HSV-1 replication. Our results show that DNA viruses including herpesviruses mimic an embryonic-like transcriptional program that prevents epigenetic silencing of the viral genome and facilitates herpesviral gene expression.
Two-layer homolog network approach for PFAS nontarget screening and retrospective data mining
Authors: Jiao Zhaoyu , Taniyasu Sachi , Yu Nanyang , Wang Xuebing , Yamashita Nobuyoshi , Wei Si 
Published: January 2025

Abstract
The rapid increase of novel per- and polyfluoroalkyl substances (PFAS) raises concerns, while their identification remains challenging. Here, we develop a two-layer homolog network approach for PFAS nontarget screening using mass spectrometry. The first layer constructs networks between homologs, with evaluation showing that it filters 94% of false candidates. The second layer builds a network between classes to expedite the identification of PFAS. We detected 94 PFAS in twelve waterproof products and two related industrial sludges, including 36 novel PFAS not previously reported in any sample. A local dataset is constructed for retrospective analysis by re-analyzing our previous samples, revealing fifteen novel PFAS in samples collected in 2005. The retrieval of the public database MassIVE uncovers novel PFAS in samples from seven countries. Here, we reveal the historic and global presence of novel PFAS, providing guidance for the management and policy-making concerning persistent chemicals.
A comprehensive assessment of current methods for measuring metacognition
Authors: Rahnev Dobromir 
Published: January 2025

Abstract
One of the most important aspects of research on metacognition is the measurement of metacognitive ability. However, the properties of existing measures of metacognition have been mostly assumed rather than empirically established. Here I perform a comprehensive empirical assessment of 17 measures of metacognition. First, I develop a method of determining the validity and precision of a measure of metacognition and find that all 17 measures are valid and most show similar levels of precision. Second, I examine how measures of metacognition depend on task performance, response bias, and metacognitive bias, finding only weak dependences on response and metacognitive bias but many strong dependencies on task performance. Third, I find that all measures have very high split-half reliabilities, but most have poor test-retest reliabilities. This comprehensive assessment paints a complex picture: no measure of metacognition is perfect and different measures may be preferable in different experimental contexts.
Digital twin assisted surgery, concept, opportunities, and challenges
Authors: Asciak Lisa , Kyeremeh Justicia , Luo Xichun , Kazakidi Asimina , Connolly Patricia , Picard Frederic , O’Neill Kevin , Tsaftaris Sotirios A. , Stewart Grant D. , Shu Wenmiao 
Published: January 2025

Abstract
Computer-assisted surgery is becoming essential in modern medicine to accurately plan, guide, and perform surgeries. Similarly, Digital Twin technology is expected to be instrumental in the future of surgery, owing to its capacity to virtually replicate patient-specific interventions whilst providing real-time updates to clinicians. This perspective introduces the term Digital Twin-Assisted Surgery and discusses its potential to improve surgical precision and outcome, along with key challenges for successful clinical translation.
A novel human fetal lung-derived alveolar organoid model reveals mechanisms of surfactant protein C maturation relevant to interstitial lung disease
Authors: Lim Kyungtae , Rutherford Eimear N , Delpiano Livia , He Peng , Lin Weimin , Sun Dawei , Van den Boomen Dick J H , Edgar James R , Bang Jae Hak , Predeus Alexander , Teichmann Sarah A , Marioni John C , Matesic Lydia E , Lee Joo-Hyeon , Lehner Paul J , Marciniak Stefan J , Rawlins Emma L , Dickens Jennifer A 
Published: January 2025

Abstract
Alveolar type 2 (AT2) cells maintain lung health by acting as stem cells and producing pulmonary surfactant. AT2 dysfunction underlies many lung diseases, including interstitial lung disease (ILD), in which some inherited forms result from the mislocalization of surfactant protein C (SFTPC) variants. Lung disease modeling and dissection of the underlying mechanisms remain challenging due to complexities in deriving and maintaining human AT2 cells ex vivo. Here, we describe the development of mature, expandable AT2 organoids derived from human fetal lungs which are phenotypically stable, can differentiate into AT1-like cells, and are genetically manipulable. We use these organoids to test key effectors of SFTPC maturation identified in a forward genetic screen including the E3 ligase ITCH, demonstrating that their depletion phenocopies the pathological SFTPC redistribution seen for the SFTPC-I73T variant. In summary, we demonstrate the development of a novel alveolar organoid model and use it to identify effectors of SFTPC maturation necessary for AT2 health.
Boarding stop inference with uncertain relationship between bus vehicles and mobile smart card readers
Authors: Zhou Peng , Shen Yu , Ji Yuxiong , Du Yuchuan 
Published: January 2025

AbstractBoarding stop inference for bus passengers is essential for the improvement of bus transit services. Previous studies mainly focus on matching the bus trajectories with the bus stop locations, while the relationship between smart card readers—which collect the smart card data—and bus vehicles is usually given. However, uncertainties arise in practical applications regarding the matching of vehicles and card readers. To tackle this challenge, in this study, a data‐driven approach is proposed to dig into the spatiotemporal features of passengers' smart card data and bus vehicle operations. A weighted bipartite graph algorithm is developed to match the smart card readers with the bus vehicles automatically. To verify the feasibility and effectiveness of the proposed approach, a case study is conducted on the Bus Anhong Line in Shanghai, China. The inferred results of boarding stops are compared with the data from passenger counting sensors installed in the bus vehicles. The matching accuracy rate achieves 0.9539, which validates the effectiveness of the proposed matching model. In addition, the inferred data are used to present the spatiotemporal patterns of boarding passengers and identify high‐demand bus stops.
Connecting energetic electrons at the Sun and in the heliosphere through X-ray and radio diagnostics
Authors: Paipa-Leon David , Vilmer Nicole , Maksimovic Milan , Krupar Vratislav , Vecchio Antonio 
Published: January 2025

Context. Solar flares release huge amounts of energy, a considerable part of which is channeled into particle acceleration in the lower corona. Hard X-ray (HXR) emissions are used to diagnose the accelerated electrons that bombard the chromosphere, while type III radio bursts result from energetic electron beams propagating through the corona and into interplanetary space. The Solar Orbiter mission, launched in 2020, aims to link solar flare remote observations with heliospheric events, thus producing useful observations for our understanding of particle acceleration and propagation from the Sun to the heliosphere.
Aims. While both hard X-Ray and radio emissions result from flare-accelerated electrons, their relationship is not straightforward. By comparing the evolution of the X-ray emitting sites and the timing of type III bursts, our aim is to determine the conditions for associations between X-ray flares and interplanetary (IP) type III bursts.
Methods. We analyzed 15 interplanetary type III bursts that are associated with HXR bursts in the first available period for simultaneous X-ray/radio observations of type III bursts from Solar Orbiter (using the RPW and STIX instruments). X-ray imaging was performed around the onset of the type III bursts, complemented by EUI 174 Å images to assess the magnetic configuration of the corona.
Results. All 15 X-ray flares originated from the same active region on the west limb as observed by Solar Orbiter. In each of the events, a change in X-ray source morphology occurred shortly (< 6 minutes) before the onset of type III radio bursts, indicating a change in the electron acceleration region preceding the radio emission. Considering the delays observed between the two emissions, these findings describe complex scenarios with multiple reconnection episodes, some of which may allow accelerated electrons to escape into IP space when open magnetic field lines are involved (interchange reconnection). In some cases, X-ray source elongations toward open field lines in the UV were observed, reinforcing this idea.
VLT VIMOS integral field spectroscopy of the nova remnant FH Ser
Authors: Guerrero M. A. , Santamaría E. , Takeda L. , González-Carbajal J. I. , Cazzoli S. , Ederoclite A. , Toalá J. A. 
Published: January 2025

Context. The source FH Ser experienced a slow classical nova outburst in February 1970 that was the first ever observed at UV, optical, and IR wavelengths. Its nova remnant is elliptical and has multiple knots. A peculiar ring-like filament lies along its minor axis.
Aims. We investigate here the true 3D spatio-kinematical structure of FH Ser to assess the effects of early shaping and to assess its mass and kinetic energy.
Methods. We obtained integral field spectroscopic observations made with the Very Large Telescope (VLT) VIsible MultiObject Spectrograph (VIMOS) of FH Ser. The data cube was analyzed using 3D visualizations that revealed different structural components. A simple geometrical model was compared to the 3D data cube to determine the spatio-kinematic properties of FH Ser.
Results. FH Ser consists of a tilted prolate ellipsoidal shell that is most prominent in Hα, and of a ring-like structure that is most prominent in [N II]. The ellipsoidal shell has equatorial and polar velocities of ≃505 and ≈630 km s−1, respectively, and its major axis is tilted by ≃52° with respect to the line of sight. The inclination angle of the symmetry axis of the ring is similar, that is, it can be described as an equatorial belt of the main ellipsoidal shell. FHSer has an ionized mass of 2.6 × 10−4 M⊙, with a kinetic energy of 1.6 × 1045 erg.
Conclusions. The two different structural components in FH Ser with a similar orientation can be linked to a density enhancement along a plane, most likely the orbital plane at the time of the nova event. The acquisition of integral field spectroscopic observations of nova remnants is mostly required to separate different structural components and to assess their 3D physical structure.
A method for asteroid detection using convolutional neural networks on VST images
Authors: Irureta-Goyena B. Y. , Rachith E. , Hellmich S. , Kneib J.-P. , Altieri B. , Lemon C. , Saifollahi T. , Hainaut O. , Freudling W. , Dux F. , Micheli M. , Ocaña F. , Ramírez-Moreta P. , Courbin F. , Conversi L. , Millon M. , Verdoes Kleijn G. , Salzmann M. 
Published: January 2025

Context. The study of asteroids, particularly near-Earth asteroids, is key to gaining insights into our Solar System and can help prevent dangerous collisions. Beyond finding new objects, additional observations of known asteroids will improve our knowledge of their orbit.
Aims. We have developed an automated pipeline to process and search for asteroid trails in images taken with OmegaCAM, the wide- field imager mounted on the VLT Survey Telescope (VST), on the European Southern Observatory’s Cerro Paranal. The pipeline inputs a FITS image and outputs the position, length, and angle of all the asteroids trails detected.
Methods. A convolutional neural network was trained on a set of synthetic asteroid trails, with trail lengths 5–120 pixels (1–25″) and S/Ns 3–20. Its performance was tested on synthetic trails and validated using real trails, chosen from the Solar System Object Image Search of the Canadian Astronomy Data Centre.
Results. On the synthetic trails, the pipeline achieved a completeness of 70% for trails with length ≥15 pixels (3″), with a precision of 82%. On the real trails, the pipeline achieved a completeness of 65%, with a precision of 44%, a lower value likely due to the higher presence of contaminants and stars in the field. The pipeline was able to detect both low- and high-S/N asteroid trails.
Conclusions. Our method shows a strong potential to make new discoveries and precoveries in VST data across the S/N range studied, especially in the fainter end, which remains largely unexplored.
Assessing Second-Trimester Ferning in Diagnosing Preterm Prelabor Rupture of Membranes
Authors: Lende Michelle N. , Lee Derek , Bringley Johanna C. , Feustel Paul J. , Lynch Tara A. 
Published: January 2025

Objective Preterm prelabor rupture of membranes (PPROM) diagnosis is made through visualization of amniotic fluid (pooling), nitrizine testing, sonographic low amniotic fluid, and microscopic detection of amniotic fluid arborization (ferning). Data exist on the specificity and sensitivity of ferning detection but have not focused on the second trimester. Our objective is to evaluate the presence of ferning in transvaginally collected amniotic fluid in pregnancies with known second-trimester PPROM to determine if there is a difference in ferning based on gestational age and sample drying time.
Study Design This was a prospective study evaluating amniotic fluid in individuals undergoing termination of pregnancy between 15 and 24 weeks gestation. A control vaginal swab was collected prior to rupture of membranes and a sample vaginal swab was collected at the time of rupture of membranes at a termination procedure. A 10-mL sample of amniotic fluid was collected too and then centrifuged to separate blood. Slides were analyzed at five different drying time intervals after rupture of membranes, on both the vaginal and centrifuged samples, and examined by two blinded investigators to assess for ferning. Maternal demographics, obstetrical history, and termination information were collected. Statistical analysis was performed using descriptive statistics and regression analyses.
Results A total of 99 individuals consented and 93 were included. The mean gestational age at the time of the termination was 19.5 ± 2.5 weeks. There was a significant effect of drying time with the odds of observing ferning increasing with longer drying time, up to 10 minutes (p < 0.001). Gestational age did not impact ferning detection (p = 0.09). Centrifuging increased ferning detection by 15% at 10 minutes compared to the vaginal swab.
Conclusion In cases of known second-trimester PPROM, ferning was detected more often after 10 minutes of sample drying, and centrifuging the amniotic fluid to remove blood.
Key Points
Neurology pioneers in Japan
Authors: Teive Hélio A. Ghizoni , Coutinho Léo , Cardoso Francisco E. C. , Tsuji Shoji 
Published: January 2025

AbstractThe pioneers of neurology in Japan were professors Hiroshi Kawahara and Kinnosuke Miura. Kawahara published the first description of progressive bulbar palsy and wrote the first neurology textbook in Japan. Miura, on the other hand, published studies about amyotrophic lateral sclerosis, in addition to participating in the founding of the Japanese Society of Neurology. The influence of European neurology, particularly French and German, in the figures of Professor Jean-Martin Charcot and Professor Erwin Bälz, was fundamental in the consolidation of neurology in Japan.
Dosage of botulinum toxin in patients undergoing treatment for hemifacial spasm: is there modification during follow-up?
Authors: Dantas Fátima de Menezes , Freire Felipe Olobardi , Pessoa Neto Agábio Diógenes , Godeiro Júnior Clécio de Oliveira , Silva Rodrigo Alencar e 
Published: January 2025

Abstract
Background The movement disorder known as hemifacial spasm is characterized by involuntary contractions of the muscles that are innervated by the facial nerve. The treatment of choice for this condition is botulinum toxin injections.
Objective To analyze the botulinum toxin dosage in patients undergoing treatment for hemifacial spasm during a 14-year period.
Methods A retrospective study of medical records from patients treated at the Neurology Service of Hospital Universitário Onofre Lopes, Universidade Federal do Rio Grande do Norte, from 2010 to 2024, was performed.
Results A total of 151 patients met the inclusion criteria. The dose of botulinum toxin revealed a statistically significant increase during the first 3.46 years of follow-up. In the long-term, a trend toward dose stabilization was identified. The median latency for the onset of effect was 4 days, while the median duration of effect was 3 months. All side effects were temporary, with the most common being hemifacial weakness (17.9%) and palpebral ptosis (3.3%). Most patients presented primary hemifacial spasm (88.1%), with a neurovascular conflict identified in 24.1% of cases.
Conclusion The increase in botulinum toxin dosage during the first years may be explained by dosage adjustment to control hemifacial spasm with the lowest possible doses. A prolonged interval between applications may also be associated with this increase. Dose stabilization tends to be achieved over time, indicating disease control.
Measuring What Matters: Patient-Reported Outcomes in Colon Cancer Care
Authors: Sokas Claire M. , Ivatury Srinivas Joga 
Published: January 2025

AbstractPatients have common and personalized questions about expected outcomes after colon cancer treatment. Surgeons and oncologists can use high-quality clinical counseling and patient-reported outcomes to identify what matters most to each patient. This article reviews common patient-centered outcomes and how to elicit personalized outcomes, preferences, and values for patients facing colon cancer.
Revisiting gravitational angular momentum and mass dipole losses in the eikonal framework
Authors: Heissenberg Carlo , Russo Rodolfo 
Published: January 2025

Abstract
We review the description of classical gravitational scatterings of two compact objects by means of the eikonal framework. This encodes via scattering amplitudes both the motion of the bodies and the gravitational-wave signals that such systems produce. As an application, we combine the next-to-leading post-Minkowskian waveform derived in the post-Newtonian PN limit with the 4PM static loss due to the linear memory effect to reproduce known results for the total angular momentum loss in the center-of-mass frame up to

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and 2.5PN order. We also provide similar expressions for the change in the system’s mass dipole, discussing the subtleties related to its sensitivity to the Coulombic components of the field and to the nonlinear memory effect.