bluuebunny/crossref_metadata_2025_split huggingface dataset:
MAVEN Observations of Tailward Reconnection Front in the Martian Magnetotail
Authors: Lin R. T. , Huang S. Y. , Yuan Z. G. , Jiang K. , Xu S. B. , Wei Y. Y. , Xiong Q. Y. , Zhang J. , Wang Z. , Yu L. 
Published: January 2023

AbstractIntense electromagnetic energy conversion and local magnetic flux transport occur at reconnection fronts (RFs) formed by magnetic reconnection. Tailward RFs (TRFs), characterized by sharply enhanced negative magnetic field normal components accompanied by tailward plasma flows, are the tailward propagating dipolarization fronts in the Earth's magnetotail. So far RFs and TRFs are observed merely at magnetized planets. Using data from Mars Atmosphere and Volatile EvolutioN, we report, for the first time, the observations of TRF embedded in a current sheet (possibly diffusion region of magnetic reconnection) in the Martian magnetotail. At the TRF, O+ and O2+ are accelerated in tailward direction; behind the TRF, the perpendicular electron fluxes enhance at the energy of 251–905 eV, which should be caused by betatron acceleration. The energized plasmas indicate that the electromagnetic energy converts to plasma kinetic energy around the TRF. Our observations suggest that RFs could occur in the planetary magnetotail without the global intrinsic dipole magnetic field.
The Roles of Local Convergences in the Convection Initiation of a Record‐Breaking Rainfall Event at the Coastal Pearl River Delta in South China
Authors: Su Lin , Sun Xian , Du Yu , Fung Jimmy C. H. , Chen Guixing 
Published: January 2023

AbstractA record‐breaking rainfall event occurred on the west coast of the Pearl River Delta (PRD) during the onset of the South China Sea Summer Monsoon in 2021. The present study quantitatively investigated the effects of local factors including land‐sea contrast, coastal terrain, and nearby convection‐induced cold pool on the convection initiation (CI) of the event. The two major local contributors to the CI of the event were the land‐sea frictional contrast on the west coast and the low‐level outflow of the cold pool produced by the rainfall system on the east coast of the PRD, which result in low‐level moisture convergence and lifting on the west coast. The two factors contributed comparably to the moisture convergence. The terrain effect on the west coast of the PRD plays a minor role in modulating the location, time, and intensity of the generated convection cells. Furthermore, the Ʌ‐shaped coastline of the Pearl River Estuary (PRE) acts to suppress convection at coastal PRD. On the west coast of the PRE, the north‐south‐oriented coastline causes a divergence of the low‐level southwesterlies, which is not conducive to moisture convergence in the area. In addition, the southwesterlies weakened by the west coast of the PRD are also unfavorable to convection on the east coast. This is distinct from previous studies focused on other areas of coastal south China with relatively straight west‐east‐oriented coastlines, where the CI can be triggered by the moisture convergence induced by the joint effects of land‐sea contrast and coastal terrain.
Assessing the Impact of Ocean In Situ Observations on MJO Propagation Across the Maritime Continent in ECMWF Subseasonal Forecasts
Authors: Du Danni , Subramanian Aneesh C. , Han Weiqing , Wei Ho‐Hsuan , Sarojini Beena Balan , Balmaseda Magdalena , Vitart Frederic 
Published: January 2023

AbstractDespite the well‐recognized initial value nature of the subseasonal forecasts, the role of subsurface ocean initialization in subseasonal forecasts remains underexplored. Using observing system experiments, this study investigates the impact of ocean in situ data assimilation on the propagation of Madden–Julian Oscillation (MJO) events across the Maritime Continent in the European Centre for Medium‐Range Weather Forecasts (ECMWF) subseasonal forecast system. Two sets of twin experiments are analyzed, which only differ on the use or not of in situ ocean observations in the initial conditions. Besides using the Real‐time Multivariate MJO Index (RMMI) to evaluate the forecast performance, we also develop a new MJO tracking method based on outgoing longwave radiation anomalies (OLRa) for forecast evaluation. We find that the ocean initialization with in situ data assimilation, though having an impact on the forecasted ocean mean state, does not improve the relatively low MJO forecast skill across the Maritime Continent. Moist static energy budget analysis further suggests that a significant underestimation in the meridional moisture advection in the model forecast may hinder the potential role played by the ocean state differences associated with data assimilation. Bias of the intraseasonal meridional winds in the model is a more important factor for such underestimation than the mean state moisture biases. This finding suggests that atmospheric model biases dominate the forecast error growth, and the atmospheric circulation bias is one of the major sources of the MJO prediction error and should be a target for improving the ECMWF subseasonal forecast model.
Groundwater Plays an Important Role in Controlling Riverine Dissolved Organic Matter in a Cold Alpine Catchment, the Qinghai–Tibet Plateau
Authors: Hu Yalu , Ma Rui , Sun Ziyong , Zheng Yan , Pan Zhao , Zhao Lusong 
Published: January 2023

AbstractIn cold alpine areas, the hydrological control on dissolved organic matter (DOM) export in relation to permafrost distribution remains uncertain on a catchment scale. To address this, the seasonal variations in DOM chemical features of groundwater and stream water were examined from 2013 to 2019 in a representative catchment on the northeastern Qinghai–Tibet Plateau, which is covered by both permafrost (at elevations higher than 3,500 m a.s.l.) and seasonally frozen areas. The results show that the highest dissolved organic carbon (DOC) concentration occurred during the thawing period (April–May), while the highest DOC flux occurred during the thawed period (June–early October). In the permafrost area, the freeze–thaw process significantly influenced the groundwater flow paths and DOM. During the thawing period, with shallow groundwater flow path through the organic soil layer, the stream water DOM recharged by suprapermafrost groundwater was characterized by high aromaticity and high DOC concentrations. During the thawed period, the deepening groundwater flow path through the mineral layer and dilution by overland flow, resulted in low DOC concentrations and DOM with lower aromaticity in stream water. When groundwater flowed from the permafrost area into the porous aquifers in the seasonally frozen area, the groundwater flow path also affected DOM dynamics. The stream water at the catchment outlet, which received groundwater discharge from the porous aquifer, showed a lower peak DOC concentration, a higher proportion of protein‐like DOM, and a higher contribution of cold season DOC flux to annual DOC flux when compared to the water flowing out from the permafrost area. Our work highlights the role of the thick, porous aquifer in the seasonally frozen area in regulating DOM export. The results suggest that the cold alpine area may exhibit a stronger positive feedback to climate warming than that in Arctic areas.
EVA1A regulates hematopoietic stem cell regeneration via ER-mitochondria mediated apoptosis
Authors: Liu Bo , Zhou Yuanyuan , Wu Qiaofeng , Fu Yuting , Zhang Xianli , Wang Zhenkun , Yi Weiwei , Wang Hu , Chen Zhiyang , Song Zhangfa , Xiong Wei , Qiu Yugang , He Weifeng , Ju Zhenyu 
Published: January 2023

AbstractExcessive protein synthesis upon enhanced cell proliferation frequently results in an increase of unfolded or misfolded proteins. During hematopoietic regeneration, to replenish the hematopoietic system, hematopoietic stem cells (HSCs) are activated and undergo a rapid proliferation. But how the activated HSCs respond to the proliferation pressure is still ambiguous; The proper control of the functional reservoir in the activated HSCs remains poorly understood. Here, we show a significant upregulation of EVA1A protein associated with the increase of ER stress during hematopoietic regeneration. Deletion of Eva1a significantly enhances the regeneration capacity of HSCs by inhibiting the ER stress-induced apoptosis. Mechanistically, the expression of EVA1A protein was upregulated by CHOP, and thereby promoted the ER-mitochondria interlinking via MCL1, which resulted in mitochondria-mediated apoptosis. These findings reveal a pathway for ER stress responses of HSCs by the EVA1A mediated apoptosis, which play an important role in HSCs regeneration.
Stabilizing copper sites in coordination polymers toward efficient electrochemical C-C coupling
Authors: Liang Yongxiang , Zhao Jiankang , Yang Yu , Hung Sung-Fu , Li Jun , Zhang Shuzhen , Zhao Yong , Zhang An , Wang Cheng , Appadoo Dominique , Zhang Lei , Geng Zhigang , Li Fengwang , Zeng Jie 
Published: January 2023

AbstractElectroreduction of carbon dioxide with renewable electricity holds promise for achieving net-zero carbon emissions. Single-site catalysts have been reported to catalyze carbon-carbon (C-C) coupling—the indispensable step for more valuable multi-carbon (C2+) products—but were proven to be transformed in situ to metallic agglomerations under working conditions. Here, we report a stable single-site copper coordination polymer (Cu(OH)BTA) with periodic neighboring coppers and it exhibits 1.5 times increase of C2H4selectivity compared to its metallic counterpart at 500 mA cm−2. In-situ/operando X-ray absorption, Raman, and infrared spectroscopies reveal that the catalyst remains structurally stable and does not undergo a dynamic transformation during reaction. Electrochemical and kinetic isotope effect analyses together with computational calculations show that neighboring Cu in the polymer provides suitably-distanced dual sites that enable the energetically favorable formation of an *OCCHO intermediate post a rate-determining step of CO hydrogenation. Accommodation of this intermediate imposes little changes of conformational energy to the catalyst structure during the C-C coupling. We stably operate full-device CO2electrolysis at an industry-relevant current of one ampere for 67 h in a membrane electrode assembly. The coordination polymers provide a perspective on designing molecularly stable, single-site catalysts for electrochemical CO2conversion.
Microbially produced vitamin B12 contributes to the lipid-lowering effect of silymarin
Authors: Sun Wen-Long , Hua Sha , Li Xin-Yu , Shen Liang , Wu Hao , Ji Hong-Fang 
Published: January 2023

AbstractSilymarin has been used for improving hepatic damage and lipid disorders, but its action mechanism remains to be clarified. Here, we investigate the contributions of the gut microbiota to the improvement of liver lipid metabolism by silymarin. We find i) strong and significant microbial shifts upon silymarin but not silibinin treatment; ii) over 60% variations of liver fat are explained by silymarin-induced bacterial B12 production in male rats but not in male germ-free mice; iii) fecal microbiota transplantation confirms their protective roles against liver fat accumulation; iv) upregulation of one-carbon metabolism and fatty acid degradation pathways are observed based on the liver transcriptome analyses; and v) in humans the delta changes of serum B12 associate negatively with the fluctuations of serum triglycerides. Overall, we reveal a mechanism of action underpinning the lipid-lowering effect of silymarin via the gut microbiota and its vitamin B12 producing capabilities.
B1 SINE-binding ZFP266 impedes mouse iPSC generation through suppression of chromatin opening mediated by reprogramming factors
Authors: Kaemena Daniel F. , Yoshihara Masahito , Beniazza Meryam , Ashmore James , Zhao Suling , Bertenstam Mårten , Olariu Victor , Katayama Shintaro , Okita Keisuke , Tomlinson Simon R. , Yusa Kosuke , Kaji Keisuke 
Published: January 2023

AbstractInduced pluripotent stem cell (iPSC) reprogramming is inefficient and understanding the molecular mechanisms underlying this inefficiency holds the key to successfully control cellular identity. Here, we report 24 reprogramming roadblock genes identified by CRISPR/Cas9-mediated genome-wide knockout (KO) screening. Of these, depletion of the predicted KRAB zinc finger protein (KRAB-ZFP)Zfp266strongly and consistently enhances murine iPSC generation in several reprogramming settings, emerging as the most robust roadblock. We show that ZFP266 binds Short Interspersed Nuclear Elements (SINEs) adjacent to binding sites of pioneering factors, OCT4 (POU5F1), SOX2, and KLF4, and impedes chromatin opening. Replacing the KRAB co-suppressor with co-activator domains converts ZFP266 from an inhibitor to a potent facilitator of iPSC reprogramming. We propose that the SINE-KRAB-ZFP interaction is a critical regulator of chromatin accessibility at regulatory elements required for efficient cellular identity changes. In addition, this work serves as a resource to further illuminate molecular mechanisms hindering reprogramming.
Multicolor hyperafterglow from isolated fluorescence chromophores
Authors: Zhang Xiao , Zeng Mingjian , Zhang Yewen , Zhang Chenyu , Gao Zhisheng , He Fei , Xue Xudong , Li Huanhuan , Li Ping , Xie Gaozhan , Li Hui , Zhang Xin , Guo Ningning , Cheng He , Luo Ansheng , Zhao Wei , Zhang Yizhou , Tao Ye , Chen Runfeng , Huang Wei 
Published: January 2023

AbstractHigh-efficiency narrowband emission is always in the central role of organic optoelectronic display applications. However, the development of organic afterglow materials with sufficient color purity and high quantum efficiency for hyperafterglow is still great challenging due to the large structural relaxation and severe non-radiative decay of triplet excitons. Here we demonstrate a simple yet efficient strategy to achieve hyperafterglow emission through sensitizing and stabilizing isolated fluorescence chromophores by integrating multi-resonance fluorescence chromophores into afterglow host in a single-component copolymer. Bright multicolor hyperafterglow with maximum photoluminescent efficiencies of 88.9%, minimum full-width at half-maximums (FWHMs) of 38 nm and ultralong lifetimes of 1.64 s under ambient conditions are achieved. With this facilely designed polymer, a large-area hyperafterglow display panel was fabricated. By virtue of narrow emission band and high luminescent efficiency, the hyperafterglow presents a significant technological advance in developing highly efficient organic afterglow materials and extends the domain to new applications.
Structural basis of the mycobacterial stress-response RNA polymerase auto-inhibition via oligomerization
Authors: Morichaud Zakia , Trapani Stefano , Vishwakarma Rishi K. , Chaloin Laurent , Lionne Corinne , Lai-Kee-Him Joséphine , Bron Patrick , Brodolin Konstantin 
Published: January 2023

AbstractSelf-assembly of macromolecules into higher-order symmetric structures is fundamental for the regulation of biological processes. Higher-order symmetric structure self-assembly by the gene expression machinery, such as bacterial DNA-dependent RNA polymerase (RNAP), has never been reported before. Here, we show that the stress-response σB factor from the human pathogen, Mycobacterium tuberculosis, induces the RNAP holoenzyme oligomerization into a supramolecular complex composed of eight RNAP units. Cryo-electron microscopy revealed a pseudo-symmetric structure of the RNAP octamer in which RNAP protomers are captured in an auto-inhibited state and display an open-clamp conformation. The structure shows that σB is sequestered by the RNAP flap and clamp domains. The transcriptional activator RbpA prevented octamer formation by promoting the initiation-competent RNAP conformation. Our results reveal that a non-conserved region of σ is an allosteric controller of transcription initiation and demonstrate how basal transcription factors can regulate gene expression by modulating the RNAP holoenzyme assembly and hibernation.
Gigahertz optoacoustic vibration in Sub-5 nm tip-supported nano-optomechanical metasurface
Authors: Gao Renxian , He Yonglin , Zhang Dumeng , Sun Guoya , He Jia-Xing , Li Jian-Feng , Li Ming-De , Yang Zhilin 
Published: January 2023

AbstractThe gigahertz acoustic vibration of nano-optomechanical systems plays an indispensable role in all-optical manipulation of light, quantum control of mechanical modes, on-chip data processing, and optomechanical sensing. However, the high optical, thermal, and mechanical energy losses severely limit the development of nano-optomechanical metasurfaces. Here, we demonstrated a high-quality 5 GHz optoacoustic vibration and ultrafast optomechanical all-optical manipulation in a sub-5 nm tip-supported nano-optomechanical metasurface (TSNOMS). The physical rationale is that the design of the semi-suspended metasurface supported by nanotips of <5 nm enhances the optical energy input into the metasurface and closes the mechanical and thermal output loss channels, result in dramatically improvement of the optomechanical conversion efficiency and oscillation quality of the metasurface. The design strategy of a multichannel-loss-mitigating semi-suspended metasurface can be generalized to performance improvements of on-chip processed nano-optomechanical systems. Applications include all-optical operation of nanomechanical systems, reconfigurable nanophotonic devices, optomechanical sensing, and nonlinear and self-adaptive photonic functionalities.
A pilot 1-year follow-up randomised controlled trial comparing metacognitive training to psychoeducation in schizophrenia: effects on insight
Authors: Lopez-Morinigo Javier-David , Martínez Adela Sánchez-Escribano , Barrigón María Luisa , Escobedo-Aedo Paula-Jhoana , Ruiz-Ruano Verónica González , Sánchez-Alonso Sergio , Mata-Iturralde Laura , Muñoz-Lorenzo Laura , Cuadras Daniel , Ochoa Susana , Baca-García Enrique , David Anthony S. 
Published: January 2023

AbstractPoor insight in schizophrenia spectrum disorders (SSD) is linked with negative outcomes. This single-centre, assessor-blind, parallel-group 1-year follow-up randomised controlled trial (RCT) tested whether metacognitive training (MCT) (compared to psychoeducation) may improve insight and outcomes in outpatients with SSD assessed: at baseline (T0); after treatment (T1) and at 1-year follow-up (T2). Insight (primary outcome) was measured with (i) the Schedule for Assessment of Insight-Expanded version- (SAI-E), including illness recognition (IR), symptom relabelling (SR), treatment compliance (TC) and total insight scores (TIS); and (ii) the Beck Cognitive Insight Scale (BCIS). Between-group comparisons were nonsignificant, while within the MCT group (but not within controls) there was a significant medium effect size for improved TIS at T2 (d = 0.67, P = 0.02). Secondary outcomes included cognitive measures: Jumping to Conclusions (JTC), Theory of Mind (ToM), plus symptom severity and functioning. Compared to psychoeducation, MCT improved the PANSS excitement (d = 1.21, P = 0.01) and depressed (d = 0.76, P = 0.05) factors at T2; and a JTC task both at T1 (P = 0.016) and at T2 (P = 0.031). Participants in this RCT receiving MCT showed improved insight at 1-year follow-up, which was associated with better mood and reduced JTC cognitive bias. In this pilot study, no significant benefits on insight of MCT over psychoeducation were detected, which may have been due to insufficient power.
A comparative study of postmortem distribution and postmortem diffusion of tramadol in rabbits
Authors: Su Hongliang , Wang Lingxiao , Wurita Amin , Zhang Chao , Wu Miaomiao , Li Bin , Niu Weifen , Wang Youmei , Wei Zhiwen , Yun Keming 
Published: January 2023

AbstractIn recent years, the cases of tramadol intoxication have become more frequent in many countries. However, most of the previous studies have been based on cases of tramadol intoxication, and the detailed information on the differences between postmortem distribution and diffusion of tramadol remains unclear. To investigate this issue systematically, we established a postmortem distribution model and two postmortem diffusion models. Then, gas chromatography-mass spectrometry (GC/MS) was used to measure the concentrations of tramadol in various biological specimens of fluids and tissues. In postmortem distribution, the results showed an uneven distribution of tramadol in various biological specimens, and the concentrations of tramadol in urine were significantly higher than those in other fluids. In postmortem diffusion, the results showed a dosage-dependent increase of tramadol concentration in most specimens; at all time points from 0.25 to 6 h after postmortem administration, the concentrations of tramadol in fluids were not significantly different from those in tissues, and the concentrations of tramadol in urine were lower than those in both tissues and other fluids in most time points. We recommend a quantitative examination of the specimens of both fluids and tissues to provide more evidence for the forensic identification, and the realization that there is a correlation between the concentrations of fluids and tissues is important for determining antemortem and postmortem administration of tramadol. This information can serve as ancillary data in inferring the contribution of a drug to death in cases of suspected tramadol poisoning.
Deontologists are not always trusted over utilitarians: revisiting inferences of trustworthiness from moral judgments
Authors: Bostyn Dries H. , Chandrashekar Subramanya Prasad , Roets Arne 
Published: January 2023

Abstract
Recent research has looked at how people infer the moral character of others based on how they resolve sacrificial moral dilemmas. Previous studies provide consistent evidence for the prediction that those who endorse outcome-maximizing, utilitarian judgments are disfavored in social dilemmas and are seen as less trustworthy in comparison to those who support harm-rejecting deontological judgments. However, research investigating this topic has studied a limited set of sacrificial dilemmas and did not test to what extent these effects might be moderated by specific features of the situation described in the sacrificial dilemma (for instance, whether the dilemma involves mortal or non-mortal harm). In the current manuscript, we assessed the robustness of previous findings by exploring how trust inference of utilitarian and deontological decision makers is moderated by five different contextual factors (such as whether the sacrificial harm is accomplished by an action or inaction), as well as by participants’ own moral preferences. While we find some evidence that trust perceptions of others are moderated by dilemma features, we find a much stronger effect of participants’ own moral preference: deontologists favored other deontologists and utilitarians favored utilitarians.

Protocol registration
The stage 1 protocol for this Registered Report was accepted in principle on 21 September 2022. The protocol, as accepted by the journal, can be found at: https://doi.org/10.6084/m9.figshare.21325953.