bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genesis of the Abunabu antimony deposits in the Tethys Himalayan metallogenic belt: Evidence from He–Ar and S isotopes of stibnite
Authors: Li Yang , Wang Chenghui , Li Yubin , Sun Yan , Puchi Mima , Zhang Xudong , Lamu Gesang , Yang Zong 
Published: January 2023

Introduction:The Abunabu antimony mining area is located between the Indus–Yarlung Tsangpo suture and the southern Tibetan detachment system. Ore deposits in the mining area provide an excellent opportunity to understand the nature and genesis of antimony mineralisation in the Tethys Himalayan metallogenic belt.Methods:In this study, we analysed the He–Ar and S isotopic compositions of stibnite-hosted fluid inclusions as a basis for investigating the sources of ore-forming fluids in the Abunabu mining area and the Tethys Himalayan metallogenic belt.Results:The analysed stibnites have4He contents of 0.016 × 10−7–1.584 × 10–7 cm3STP/g,40Ar contents of 1.37 × 10−7–2.94 × 10–7 cm3STP/g,40Ar/36Ar ratios of 303.8–320.7, and3He/4He (Ra) ratios of 0.021–0.351. These isotopic features indicate that the ore-forming fluids were primarily metamorphic fluids of crustal origin, with small amounts of magmatic-derived materials and modified air-saturated water with low40Ar*/4He ratios. The δ34S values of stibnite vary within a narrow range of −4.9‰ to −3.5‰, with a mean value of −4.31‰, indicating a deep magmatic origin.Discussion:On the basis of these results and a compilation of data for sulphide deposits in the metallogenic belt, we infer that compositional variations in the He and Ar isotopes of the ore-forming fluids of each antimony deposit in the Tethys Himalayan metallogenic belt are independent of each other. This suggests that antimony deposits in the belt had similar ore-forming fluid sources and mixing processes and that differences in the metallogenic tectonic setting within the belt emerged only in the later stages of deposit evolution. Our new results and compiled data also show that antimony–gold deposits and lead–zinc–antimony polymetallic deposits in the Tethys Himalayan metallogenic belt differ in their sulphur isotopic compositions and that multiple sulphur sources were involved in each of these types of deposit.
Fluid mineralization of the Dongtongyu gold deposit in the southern margin of North China craton: Evidence from microthermometry and composition of fluid inclusions
Authors: Wei Hao , Xu Liangwei , Li Dong , Feng Yunlei , Wu Xiaogui , Chang Honglun , Wang Duixing , Liu Zhuo , Du Wenbiao 
Published: January 2023

In this study, petrographic, microthermometric, and synchrotron radiation X-ray fluorescence (SRXRF) analyses of fluid inclusions were conducted to shed light on the mineralization mechanism of the Dongtongyu deposit and provide some evidence of the relationship among CO2, Au, and other ore elements (e.g., Cu, Fe, Zn, and Pb) in ore-forming fluids. The ore-forming fluid is characterized as the H2O–CO2–NaCl system with medium–high temperatures and low salinities. Four structural mineralization stages are distinguished: Pyrite-quartz (Stage 1), gold-quartz-pyrite (Stage 2), gold-quartz-polymetallic sulfide (Stage 3), and quartz-calcite (Stage 4). Fluid inclusions in Stages 1–3 are dominated by the H2O–CO2 type, and most of them contain liquid H2O and liquid CO2 at room temperature. The melting temperatures (Tm-CO2 = −82.1°C to −57.5°C) of solid CO2 in Stage 1 are relatively low. The values of Tm-CO2 in Stages 2–3 are quite close, with ranges of −60.5°C to −56.5°C and −59.2°C to −58.6°C, respectively. The melting temperatures of clathrate in Stages 1–3 are −2.7°C to +7.8°C, −5.5°C to +7.8°C, and +3.7°C to +7.2°C. The homogenization temperatures of the CO2 phase in the H2O–CO2 inclusions of the three stages are measured as −7.5°C to +31.7°C, −7.5°C to +29.3°C, and 7.1°C to +24.1°C. The total homogenization temperatures in Stages 1–3 are 180°C–394°C, 202°C–305°C, and 224°C–271°C, with salinities of 4.3 wt.%–18.2 wt% NaCl, 4.3 wt.%–20.0 wt% NaCl, and 5.3 wt.%–11.0 wt% NaCl, respectively. The laser Raman spectroscopy results show that the CO2–H2O inclusions in the quartz veins contain abundant CO2 and CH4. The SRXFR results show that most of the elements, especially As, Te, and Cu, are more enriched in liquid CO2 than in liquid H2O. The elements of Au, Fe, Ni, Cu, and Pb have higher concentrations in H2O–CO2-type fluid inclusions in Stage 2 than other fluid inclusions in Stages 1–2, suggesting that gold mineralization is closely related to CO2-rich fluids. During the fluid evolution process, fluid immiscibility is an important mineralization mechanism of gold. The increase in CO2 and CH4 and the decrease in the fluid temperature might promote fluid immiscibility.
Partial melting of amphibolitic lower crust and subsequent melt-crystal separation for generation of the Early Eocene magmatism in eastern Himalaya
Authors: Dai Zuowen , Yang Zhiming , Li Guangming , Xie Yuling , Dong Lei , Gao Ke , Cao Huawen 
Published: January 2023

The Himalayan leucogranites provide a good opportunity to investigate the crustal evolution of the southern Qinghai-Tibet Plateau. In this study, we present zircon U-Pb and monazite U-Th-Pb ages, zircon Hf isotopes and whole-rock Sr-Nd-Pb isotopes and major and trace elements for the Liemai two-mica granite, eastern Himalaya. Together with previously published data we revalued the petrogenesis of the Early Eocene magmatic rocks in this region and their geological implications. The zircon and monazite U-(Th)-Pb dating results showed that the Liemai two-mica granite was generated at ∼ 43 Ma, similar to adjacent Yardoi, Dala and Quedang adakitic two-mica granites, Ridang subvolcanic rocks and Yardoi leucogranite. The Liemai two-mica granite, similar to these coeval adakitic two-mica granites, is enriched in SiO2, Al2O3, Th, U, Pb, La, and Sr, and depleted in MgO, total iron, Yb and Y with high Sr/Y and (La/Yb)N ratios (showing adakitic affinities), and exhibits enriched Sr-Nd-Pb-Hf isotopic compositions, suggesting an origin of a thickened lower crust consisting mainly of garnet amphibolite. Although the Ridang subvolcanic rocks and Yardoi leucogranite show similar Sr-Nd-Hf isotopes to these adjacent coeval two-mica granites, perceptible differences in whole-rock major and trace elements can be observed. Broadly, these granites can be divided into high-Mg# granites (HMGs, the two-mica granites) and low-Mg# granites (LMGs, the Ridang subvolcanic rocks and Yardoi leucogranite). The former has relatively higher contents of total iron, MgO, Mg#, TiO2, P2O5, LREE, Y, Th, Sr, incompatible elements (Cr and Ni) and Eu/Eu* values, and lower contents of SiO2 and Rb/Sr and Rb/Ba ratios, thus is less evolved than the latter. According to recent studies of differentiation processes in silicic magma reservoirs, we proposed that the HMGs represent a congealed crystal mush that was composed of ‘cumulate crystals’ and a trapped interstitial liquid, while the LMGs represent the almost pure liquid that was extracted from the crystal mush. Modeling using the trace elements Sr and Ba shows that the extraction probably occurred when the crystallinity of the mush was ∼ 60%–63%, at least for the most evolved LMGs sample. The HMGs correspond to a residual crystal mush that had a terminal porosity of ∼ 21%–25% filled with a trapped interstitial liquid. Underplating of mafic magmas following slab breakoff of the Neo-Tethys oceanic lithosphere caused partial melting of the amphibolitic lower crust, which had been thickened to ~50 km prior to ~43 Ma.
Trends in epidemiology of hyperglycemia in pregnancy in Taiwan, 2008-2017
Authors: Lin Shin-Yu , Wu Yi-Ling , Kuo Chun Heng , Lee Chien-Nan , Hsu Chih-Cheng , Li Hung-Yuan 
Published: January 2023

BackgroundHyperglycemia in pregnancy (HIP) increases the risk of adverse pregnancy outcomes. The increasing prevalence of overweight or obesity and the increasing proportion of pregnant women with advanced maternal age (AMA) in the recent decade may affect its prevalence. We analyzed the secular trend of HIP prevalence in 2008-2017 in Taiwan and investigated the impact of AMA in this study.MethodsThis cross-sectional study used data from Health and Welfare Data Science Center. Pregnant women who registered their data in the Birth Certificate Application in 2008-2017 were recruited. Diagnosis of HIP was defined by ICD-9-CM and ICD-10-CM codes.ResultsIn 2008-2017, 151,306-211,768 pregnant women were recruited in different years. The proportion of women with AMA increased from 15.8% to 32.1%. Meanwhile, the prevalence increased from 0.5% to 0.9% for preexisting diabetes, 0.2% to 0.4% for undiagnosed diabetes, and 11.4% to 14.5% for GDM. Maternal age was significantly associated with the prevalence of HIP. For women aged &lt;30 years, 30-34 years and ≥35 years, the prevalence of preexisting diabetes were 0.51%, 0.75% and 1.24%, respectively (p&lt;0.05); the prevalence of undiagnosed diabetes were 0.18%, 0.24% and 0.37%, respectively (p&lt;0.05); and the prevalence of GDM were 10.57%, 14.77% and 18.13%, respectively (p&lt;0.05). In all age groups, the prevalence of HIP increased over time in 2008-2017.ConclusionThe prevalence of HIP increased in Taiwan in 2008-2017, which may result from the increasing proportion of pregnant women with AMA and the change in the diagnostic criteria for GDM.
Using hyperhomocysteinemia and body composition to predict the risk of non-alcoholic fatty liver disease in healthcare workers
Authors: Hao Xiaoyan , He Honghai , Tao Liyuan , Wang Peng 
Published: January 2023

PurposeThis study investigated associations between serum homocysteine levels, body composition, and the probability of having nonalcoholic fatty liver disease (NAFLD) in Chinese healthcare workers.Patients and MethodsA total of 4028 healthcare workers were enrolled in this study, and all underwent a physical examination. Body composition was measured using multifrequency bioelectrical impedance analysis.ResultsThere were 1507 NAFLD patients (72.26% male, 27.74% female) and 2521 controls (39.83% male, 60.17% female). Body mass index (BMI), waistline, neck-circumference (NC), abdominal visceral fat area (AVFA), total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), glucose (Glu), homocysteinemia (hcy) were higher in the NAFLD group than controls. Additionally, the skeletal-muscle was associated with a lower risk of NAFLD, whereas BMI, waistline, NC, hyperhomocysteinemia (HHcy) were associated with a higher risk of NAFLD. The best NC cut-off point for NAFLD was 34.45 cm (sensitivity 83.3% and specificity 83.9%) in women with HHcy, and the best skeletal-muscle content cut-off point for NAFLD was 41.335% (sensitivity 74.2% and specificity 65.6%) in men with HHcy.ConclusionInteractions between skeletal-muscle content, NC, and HHcy may affect the incidence of NAFLD in healthcare workers. This may provide a novel approach for diagnosing NAFLD.
Extracellular vesicles of human diabetic retinopathy retinal tissue and urine of diabetic retinopathy patients are enriched for the junction plakoglo bin protein
Authors: Mighty Jason , Rubio-Navarro Alfonso , Shi Cui , Zhou Jing , Flores-Bellver Miguel , Heissel Søren , Onwumere Onyekwere , Einbond Linda , Gharbaran Rajendra , Casper Daniel S. , Benito-Martin Alberto , Redenti Stephen 
Published: January 2023

IntroductionDiabetic Retinopathy (DR) is a potentially blinding retinal disorder that develops through the pathogenesis of diabetes. The lack of disease predictors implies a poor prognosis with frequent irreversible retinal damage and vision loss. Extracellular Vesicles (EVs) present a novel opportunity for pre-symptomatic disease diagnosis and prognosis, both severely limited in DR. All biological fluids contain EVs, which are currently being studied as disease biomarkers. EV proteins derived from urine have emerged as potential noninvasive biomarkers.MethodsIn this study, we isolated EVs from DR retinal tissue explants and from DR patients’ urine, and characterized the vesicles, finding differences in particle number and size. Next, we performed proteomic analysis on human explanted DR retinal tissue conditioned media, DR retinal EVs and DR urinary EVs and compared to normal human retinal tissue, retinal EVs, and urinary EVs, respectivelyResultsOur system biology analysis of DR tissue and EV expression profiles revealed biological pathways related to cell-to-cell junctions, vesicle biology, and degranulation processes. Junction Plakoglobin (JUP), detected in DR tissue-derived EVs and DR urinary EVs, but not in controls, was revealed to be a central node in many identified pathogenic pathways. Proteomic results were validated by western blot. Urinary EVs obtained from healthy donors and diabetic patient without DR did not contain JUP.ConclusionThe absence of JUP in healthy urinary EVs provide the basis for development of a novel Diabetic Retinopathy biomarker, potentially facilitating diagnosis.
Conventional ultrasonography and elastosonography in diagnosis of malignant thyroid nodules: A systematic review and meta-analysis
Authors: Zhang Dian , Wang Xiao-Na , Jiang Li , Yu Chun-Xia , Chen Yue-Nan , Yu Xue-Juan , Pan Mei-Fang 
Published: January 2023

PurposeTo evaluate the diagnostic value of conventional ultrasound and elastosonography in malignant thyroid nodules by meta-analysis.MethodsThe literature included in the Cochrane Library, PubMed, and Embase were searched by using “elastosonography, ultrasonography, thyroid nodules” as the keywords. The clinical studies using elastosonography and conventional ultrasound to diagnose thyroid nodules were selected, and histopathology of thyroid nodules was used as reference standards. The quality evaluation and heterogeneity test were performed on the literature that met the requirements, the combined specificity and sensitivity were pooled, and a comprehensive ROC curve analysis was performed. The Quality Assessment of Diagnostic Accuracy Studies (QUADAS) tool was utilized to evaluate the quality of each included study. Meta-DiSc version 1.4, StataSE 12 and Review Manager 5.4 were used.ResultsA total of nine studies assessed 3066 thyroid nodules (2043 benign and 1023 malignant). The pooled sensitivity, specificity, PLR, NLR, and DOR of conventional ultrasound for the diagnose of malignant thyroid nodules were 0.833 (95% CI 0.809-0.855), 0.818 (95% CI 0.801-0.835), 4.85 (95% CI 4.36-5.39), 0.20 (95% CI 0.17-0.23), and 29.38 (95% CI 23.28-37.08), respectively, with an AUC of 0.9068. Also, the pooled sensitivity, specificity, PLR, NLR, and DOR of elastosonography were 0.774 (95% CI 0.741-0.804), 0.737 (95% CI 0.715-0.758), 3.14(95% CI 2.85-3.47), 0.29 (95% CI 0.25-0.34), and 9.35 (95% CI 7.63-11.46), respectively, with an AUC of 0.8801. Three studies provided data regarding the conventional ultrasound and elastosonography. The pooled sensitivity, specificity, PLR, NLR, DOR, and AUC were 0.902 (95% CI 0.870-0.928), 0.649 (95% CI 0.616-0.681), 2.72 (95% CI 2.46-3.00), 0.14 (95% CI 0.11-0.19), 25.51 (95%CI 17.11–38.03), and 0.9294.ConclusionThe existing evidence shows that elastosonography cannot completely replace conventional ultrasound in the diagnosis of malignant thyroid nodules, and the combination of elastosonography and conventional ultrasound gives a better diagnostic precision.Systematic review registrationwww.crd.york.ac.uk, identifier PROSPERO CRD42022375808.
Dual-energy spectral detector computed tomography differential diagnosis of adrenal adenoma and pheochromocytoma: Changes in the energy level curve, a phenomenon caused by lipid components?
Authors: Wang Yu-li , Liu Xiao-lei , Liao Ze-bing , Lu Xiao-mei , Chen Ling-lin , Lei Yi , Zhang Han-wen , Lin Fan 
Published: January 2023

Background and objectivesPheochromocytoma and adrenal adenoma are common space-occupying lesions of the adrenal gland, and incorrect surgery may lead to adrenal crisis. We used a new method, dual-energy spectral detector computed tomography (SDCT), to differentiate between the two.Materials and methodsWe analysed the imaging images of patients with SDCT scans and pathologically confirmed adrenal adenomas (n=70) and pheochromocytomas (n=15). The 40, 70, and 100 KeV virtual monoenergetic images (VMIs) were reconstructed based on the SCDT arterial phase, and the correlation between the arterial/venous phase iodine concentration (AP-IC/VP-IC), the effective atomic number (Z-effect), the slope of the Hounsfield unit attenuation plot (VMI slope) and the pathological results was tested. The Shapiro−Wilk test was used to determine whether the above data conformed to a normal distribution. For parameters with P greater than 0.05, Student’s t test was used, and the Mann−Whitney test was used for the remaining parameters. A ROC curve was drawn based on the results.ResultsStudent’s t test showed that the 40 KeV VMI and the VMI slope were both statistically significant (P&lt;0.01). The Mann−Whitney U test showed that ID-A was statistically significant (P=0.004). ROC curve analysis showed that 40 keV VMI (AUC=0.818), AP-IC (AUC=0.736), difference (AUC=0.817) and VMI-Slope (0.817) could be used to differentiate adrenal adenoma from pheochromocytoma.ConclusionThe effect of lipid components on SDCT parameters can be used to differentiate adrenal adenoma from pheochromocytoma.
Real-time Volt-Var control of grid forming converters in DER-enriched distribution network
Authors: Wagle Raju , Sharma Pawan , Sharma Charu , Amin Mohammad , Gonzalez-Longatt Francisco 
Published: January 2023

The growing installation of distributed energy resources (DERs) in a distribution network (DN) poses substantial issues related to voltage regulation. Due to constrained switching operation and slower response time, traditional voltage regulation devices cannot handle current voltage-related challenges. One alternative to solve these problems is to use smart converters to control the reactive power to regulate the voltage. Volt-Var control (VVC) is one of the simplest approaches for controlling the reactive power from smart converters. Among several converters, grid forming converters (GFCs) are more suitable in DER-enriched distribution networks. Since DER-enriched distribution networks have a higher fluctuation in voltage profile, real-time control is advantageous. Therefore, this work presents an advanced real-time reactive power control for handling voltage violations in a DN using GFC. The uniqueness of this method is that it controls the voltage magnitude of affected nodes by dispatching reactive power from smart converters in real-time. By running cyber-physical co-simulation (CPCS) between the Typhoon HIL 604 and OpenDSS, the Volt-Var control can be done in real time. The grid-forming converter is modelled in Typhoon HIL 604, which acts as a physical layer of the proposed cyber-physical system for real-time VVC. A CIGRE medium voltage distribution network is designed in OpenDSS and serves as one of the parts of the cyber layer. The CPCS between Typhoon HIL and OpenDSS and the control algorithm are both done by a programme written in Python. The execution of the control algorithm is performed in real time using the Supervisory Control and Data Acquisition (SCADA) developed in this study. The real-time simulation shows that the proposed real-time VVC is capable of handling voltage violations in real time in DER-enriched distribution networks.
Meteorological impacts on surface ozone: A case study based on Kolmogorov–Zurbenko filtering and multiple linear regression
Authors: Li Menghui , Geng Chunmei , Li Liming , Zheng Zhensen , Xu Bo , Yang Wen , Wang Xinhua 
Published: January 2023

Ozone variation, excluding meteorological effects, is very important to assess the effects of air pollution control policies. In this study, the Kolmogorov-Zurbenko (KZ) filter method and multiple linear stepwise regression are combined to study the impact of meteorological parameters on ozone concentration over the past 5 years (2016–2020) in a petrochemical industrial city in northern China. Monte Carlo simulations were used to evaluate the reliability for the potential quasi quantitative prediction of the baseline component. The average level of the city and the details of five stations in the city were studied. The results show that the short-term, seasonal, and long-term component variances of maximum daily running average 8 h (MDA8) ozone in Zibo city (City) decomposed by the KZ filter account for 32.06%, 61.67% and 1.15% of the total variance, for a specific station, the values were 32.37%–34.90%, 56.64%–62.00%, and .35%–3.14%, respectively. The average long-term component increase rate is 3.19 μg m−3 yr−1 on average for the city, while it is 1.52–5.95 μg m−3 yr−1 for a specific station. The overall meteorological impact was not stable and fluctuated between −2.60 μg m−3 and +3.77 μg m−3. This difference in trends between the city and specific stations implied that the O3 precursor’s mitigation strategy should be more precise to improve its practical effects.
Immune infiltration and a necroptosis-related gene signature for predicting the prognosis of patients with cervical cancer
Authors: Xing Xuewei , Tian Yanan , Jin Xuan 
Published: January 2023

Background: Cervical cancer (CC), the fourth most common cancer among women worldwide, has high morbidity and mortality. Necroptosis is a newly discovered form of cell death that plays an important role in cancer development, progression, and metastasis. However, the expression of necroptosis-related genes (NRGs) in CC and their relationship with CC prognosis remain unclear. Therefore, we screened the signature NRGs in CC and constructed a risk prognostic model.Methods: We downloaded gene data and clinical information of patients with cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC) from The Cancer Genome Atlas (TCGA) database. We performed functional enrichment analysis on the differentially expressed NRGs (DENRGs). We constructed prognostic models and evaluated them by Cox and LASSO regressions for DENRGs, and validated them using the International Cancer Genome Consortium (ICGC) dataset. We used the obtained risk score to classify patients into high- and low-risk groups. We employed the ESTIMATE and single sample gene set enrichment analysis (ssGSEA) algorithms to explore the relationship between the risk score and the clinical phenotype and the tumor immune microenvironment.Results: With LASSO regression, we established a prognostic model of CC including 16 signature DENRGs (TMP3, CHMP4C, EEF1A1, FASN, TNF, S100A10, IL1A, H1.2, SLC25A5, GLTP, IFNG, H2AC13, TUBB4B, AKNA, TYK2, and H1.5). The risk score was associated with poor prognosis in CC. Survival was lower in the high-risk group than the low-risk group. The nomogram based on the risk score, T stage, and N stage showed good prognostic predictive power. We found significant differences in immune scores, immune infiltration analysis, and immune checkpoints between the high- and low-risk groups (p &lt; 0.05).Conclusion: We screened for DENRGs based on the TCGA database by using bioinformatics methods, and constructed prognostic models based on the signature DENRGs, which we confirmed as possibly having important biological functions in CC. Our study provides a new perspective on CC prognosis and immunity, and offers a series of new targets for future treatment.