bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characterization of visual processing in temporomandibular disorders using functional magnetic resonance imaging
Authors: Harper Daniel E. , Gopinath Kaundinya , Smith Jeremy L. , Gregory Mia , Ichesco Eric , Aronovich Sharon , Harris Richard E. , Harte Steven E. , Clauw Daniel J. , Fleischer Candace C. 
Published: February 2023

AbstractBackground and PurposeMany patients with chronic pain report hypersensitivity not only to noxious stimuli, but also to other modalities including innocuous touch, sound, and light, possibly due to differences in the processing of these stimuli. The goal of this study was to characterize functional connectivity (FC) differences between subjects with temporomandibular disorders (TMD) and pain‐free controls during a visual functional magnetic resonance imaging (fMRI) task that included an unpleasant, strobing visual stimulus. We hypothesized the TMD cohort would exhibit maladaptations in brain networks consistent with multisensory hypersensitivities observed in TMD patients.MethodsThis pilot study included 16 subjects, 10 with TMD and 6 pain‐free controls. Clinical pain was characterized using self‐reported questionnaires. Visual task‐based fMRI data were collected on a 3T MR scanner and used to determine differences in FC via group independent component analysis.ResultsCompared to controls, subjects with TMD exhibited abnormally increased FC between the default mode network and lateral prefrontal areas involved in attention and executive function, and impaired FC between the frontoparietal network and higher order visual processing areas.ConclusionsThe results indicate maladaptation of brain functional networks, likely due to deficits in multisensory integration, default mode network function, and visual attention and engendered by chronic pain mechanisms.
Examining the influence of employee engagement in supporting the implementation of green supply chain management practices: A green human resource management perspective
Authors: Graham Stephanie , Cadden Trevor , Treacy Raymond 
Published: February 2023

AbstractHow implementation of environmental practices is supported by employee engagement remains underexplored in the literature. Based on the natural resource‐based view (NRBV), this study examines the role of employee engagement in supporting successful implementation of green supply chain management (GSCM) practices. Specifically, we theorise and test the mediating role of employee engagement on the relationship between GSCM practices and environmental performance. Survey data from 394 manufacturing firms were used to test the model and hypotheses. Our findings show that employee engagement plays an important role in supporting the implementation of most GSCM practices. Non‐significant results in relation to eco‐design practices suggest that employee engagement is not as important for supporting product design‐based GSCM practices. Our study provides insights for managers and scholars seeking to address important questions around ‘how’ GSCM practices can be implemented effectively.
Antitumor therapy for breast cancer: Focus on tumor‐associated macrophages and nanosized drug delivery systems
Authors: Zhan Cuiping , Jin Ying , Xu Xinzhi , Shao Jiangbo , Jin Chunxiang 
Published: February 2023

AbstractBackgroundIn breast cancer (BC), tumor‐associated macrophages (TAMs) are an important component of the tumor microenvironment and are closely related to poor prognosis. A growing number of studies have focused on the role of TAMs in BC progression and therapeutic strategies targeting TAMs. As an emerging treatment, the application of nanosized drug delivery systems (NDDSs) in the treatment of BC by targeting TAMs has attracted much attention.AimsThis review is to summarize the characteristics and treatment strategies targeting TAMs in BC and to clarify the applications of NDDSs targeting TAMs in the treatment of BC by targeting TAMs.Materials & MethodsThe existing results related to characteristics of TAMs in BC, BC treatment strategies by targeting TAMs, and the applications of NDDSs in these strategies are described. Through analyzing these results, the advantages and disadvantages of the treatment strategies using NDDSs are discussed, which could provide advices on designing NDDSs for BC treatment.ResultsTAMs are one of the most prominent noncancer cell types in BC. TAMs not only promote angiogenesis, tumor growth and metastasis but also lead to therapeutic resistance and immunosuppression. Mainly four strategies have been used to target TAMs for BC therapy, which include depleting macrophages, blocking recruitment, reprogramming to attain an anti‐tumor phenotype, and increasing phagocytosis. Since NDDSs can efficiently deliver drugs to TAMs with low toxicity, they are promising approaches for targeting TAMs in tumor therapy. NDDSs with various structures can deliver immunotherapeutic agents and nucleic acid therapeutics to TAMs. In addition, NDDSs can realize combination therapies.DiscussionTAMs play a critical role in the progression of BC. An increasing number of strategies have been proposed to regulate TAMs. Compared with free drugs, NDDSs targeting TAMs improve drug concentration, reduce toxicity and realize combination therapies. However, in order to achieve better therapeutic efficacy, there are still some disadvantages that need to be considered in the design of NDDSs.ConclusionTAMs play an important role in the progression of BC, and targeting TAMs is a promising strategy for BC therapy. In particular, NDDSs targeting TAMs have unique advantages and are potential treatments for BC.
Air‐tolerant upconverted circularly polarized luminescence enabled by confined space of chiral micelle
Authors: Huang Jiang , Yang Xuefeng , Zhou Jin , Xie Helou , Duan Pengfei 
Published: February 2023

AbstractCircularly polarized luminescence (CPL) has been widely demonstrated that the circular polarization in excited state can be significantly amplified through the triplet‐triplet annihilation‐based upconversion (TTA‐UC) luminescence process in various chiral nano‐assemblies. However, constructing such an upconverted circularly polarized luminescence (UC‐CPL) system in the aqueous phase remains a challenge. In this work, a kind of amphiphilic chiral cationic gemini surfactant is utilized to construct chiral spherical micelle in the aqueous phase, whose internal chiral cavity can provide a hydrophobic and deoxygenated environment for air‐sensitive TTA‐UC system. In addition, due to the co‐assembly process between the emitters and chiral micelles, achiral emitters of upconversion pairs exhibit induced chiroptical properties. More importantly, the luminescence dissymmetry factor (glum) can be amplified by one order of magnitude through TTA‐UC process. This work provides an effective and useful strategy for realizing UC‐CPL in aqueous phase.
Nuclear membrane irregularity in high‐grade urothelial carcinoma cells can be measured by using circularity and solidity as morphometric shape definitions in digital image analysis of urinary tract cytology specimens
Authors: Harvey Samuel E. , VandenBussche Christopher J. 
Published: February 2023

AbstractBackgroundThe Paris System for Reporting Urine Cytology defines objective (elevated nuclear/cytoplasmic ratio ≥0.7) and subjective (nuclear membrane irregularity, hyperchromicity, and coarse chromatin) cytomorphologic criteria to identify conventional high‐grade urothelial carcinoma (HGUC) cells. Digital image analysis allows quantitative and objective measurement of these subjective criteria. In this study, digital image analysis was used to quantitate nuclear membrane irregularity in HGUC cells.MethodsWhole‐slide images of HGUC urine specimens were acquired, and HGUC nuclei were manually annotated using the open‐source bioimage analysis software QuPath. Custom scripts were used to calculate nuclear morphometrics and perform downstream analysis.ResultsIn total, 1395 HGUC cell nuclei were annotated across 24 HGUC specimens (48.1 ± 6.0 nuclei per case) using both pixel‐level and smooth annotation approaches. Nuclear membrane irregularity was estimated by calculating nuclear circularity and solidity. Annotating at pixel‐level resolution artifactually increases nuclear membrane perimeter, thus smoothing is necessary to better approximate a pathologist's assessment of nuclear membrane irregularity. After smoothing, nuclear circularity and solidity discriminate between HGUC cell nuclei with visually apparent differences in nuclear membrane irregularity.ConclusionsNuclear membrane irregularity defined by The Paris System for Reporting Urine Cytology is inherently subjective. This study identifies nuclear morphometrics that visually correlate with nuclear membrane irregularity. HGUC specimens show intercase variation in nuclear morphometrics, with some nuclei appearing remarkably regular while others show marked irregularity. A small population of irregular nuclei generates most of the intracase variation in nuclear morphometrics. These results highlight nuclear membrane irregularity as an important, but not definitive, cytomorphologic criterion in HGUC diagnosis.
Risk stratification of cytologically indeterminate thyroid nodules with nondiagnostic or benign cytology on repeat FNA: Implications for molecular testing and surveillance
Authors: Hall Elizabeth A. , Hartzband Pamela , VanderLaan Paul A. , Nishino Michiya 
Published: February 2023

AbstractBackgroundEvidence guiding the management of cytologically indeterminate thyroid nodules with nondiagnostic (ND) or benign cytology on repeat fine‐needle aspiration (FNA) is limited. This study evaluates the utility of molecular testing and estimates the risk of noninvasive follicular thyroid neoplasm with papillary‐like nuclear features (NIFTP) and cancer among such nodules.MethodsThis was a retrospective single‐institution review of thyroid nodules from adults that were classified as atypia of undetermined significance (AUS) or follicular neoplasm (FN) on initial FNA and underwent repeat FNA for cytology and Afirma testing (June 2013–July 2021). The association between repeat FNA cytology and RNA yield for Afirma was determined. Histologic outcomes were integrated with Afirma results to define end points for each nodule.ResultsA total of 691 AUS and FN nodules underwent repeat FNA and Afirma testing. Diagnostic Afirma results were obtained in 98% of cases overall and in 91% of nodules with ND cytology on repeat FNA. Using combined molecular and histologic end points, the NIFTP and/or cancer prevalence for nodules with ND cytology on repeat FNA was 9% (95% confidence interval [CI], 0.042–0.182), falling between those nodules classified as benign (5%; 95% CI, 0.029–0.094) and those classified as AUS or FN (18%; 95% CI, 0.140–0.218) on repeat FNA, although not reaching statistical significance from either subgroup (p = .38 and .10, respectively).ConclusionsAUS and FN nodules that are ND on repeat FNA have low but nonnegligible risk of NIFTP and/or cancer and may benefit from molecular testing, given the low test failure rate in this subgroup. Conversely, AUS and FN nodules reclassified as benign on repeat FNA have a very low risk of NIFTP and/or cancer and are unlikely to benefit from molecular testing.
Burden of illness in aromatic l‐amino acid decarboxylase deficiency
Authors: DiBacco Melissa L. , Hinahara Jordan , Goss Thomas F. , Pearl Phillip L. 
Published: February 2023

AbstractObjectivesDeficiency of aromatic l‐amino acid decarboxylase (AADC), a key enzyme in monoamine synthesis, is an ultrarare disorder of monoamine synthesis estimated to affect fewer than 50 patients in the United States, although rates of misdiagnosis may be high. In its severe form, this congenital hypodopaminergic state results in profound hypotonia, developmental impairment, oculogyric crises, dystonia, dysautonomia, hypoglycemia, and premature death. The present study assesses the burden of illness for patients and caregivers by assessment of medical resource utilization (MRU) and quality of life (QOL) measures to enable future health technology assessment activities for emerging therapeutic options.MethodsData from patients’ medical records from the prior two years were examined to estimate burden in terms of direct costs; indirect care burden (including caregiver impact on sleep, health, and vocational opportunities) and QOL were also assessed using the BURQOL‐RD, AQoL‐6, and Visual Analogue Scale questionnaires.ResultsData were available for five US cases (three males, two females; age, 2–24 years, median, 5 years). MRU ranged from $6162.73 to $49 043.94 annually per patient. Although the proportion of costs (inpatient and outpatient visits, labs/tests, drugs, devices/durable medical equipment, and speech/physical therapy) varied greatly, the average annual direct cost of healthcare was approximately $25 000. Caregivers described profound care burden and QOL effects, with an average indirect care burden cost assessment of nearly $43 000 yearly. The mean economic burden of AADC deficiency per year was estimated at $68 000.ConclusionMRU and QOL varied considerably by patient. This is attributable to the disease's variable phenotypic severity and differing patient needs. Frequent contact with the healthcare system, however, is a constant for patients with AADC deficiency and their caregivers. Quantifying MRU and QOL for rare genetic diseases is critical for assessing the value of emerging targeted therapies.
Opportunistic coding across on‐route dominating nodes in a flow‐orientedSDNenabledWSN
Authors: Singh Amit 
Published: February 2023

SummaryWith the aid of network coding, numerous packets can be mixed at intermediary nodes if any encoding opportunity exists. However, it is challenging to choose intermediate relay nodes of probable opportunistic coding in distributed wireless networks. In this work, a wireless sensor network (WSN) is employed with a software defined network (SDN) architecture along with a connected dominating set (CDS)‐based routing technique. The SDN offers a centrally managed architecture that lowers energy usage and network traffic by reducing the controlling and managing overheads in sensory networks. In addition, the CDS‐based routing and the potential for opportunistic coding at dominant nodes are coupled to enhance network performance. The proposed CDS‐based flow‐oriented coding‐aware energy‐efficient routing (CFCER) is contrasted with existing traditional wireless sensor networks and software‐defined sensor networks in terms of throughput, packet delay, and energy usage. CFCER increases network throughput by 15% more than SDN‐based WSN and by about 25% more than traditional WSN. However, compared to standard WSN, a significant improvement was made in packet delay and energy conservation. Over SDN‐WSN, packet delay is reduced by about 18%, and the energy consumption is cut by 10%.
Experimental results and analysis of midrange underwater wireless power transfer
Authors: Niu Wangqiang , Yu Xuejie , Zhang Weiting 
Published: February 2023

SummaryIt is reported generally in previous studies that the transmission efficiency of wireless power transfer (WPT) system in seawater is lower than that in air due to eddy current loss. In this study, it is found experimentally that the transfer efficiency in seawater can reach 17 times of that in air on average at midrange for a WPT system with two 22.5‐cm planar coils and a 460‐kHz resonance frequency. These show that the eddy current assists wireless transfer in seawater, and then the eddy current is treated as a relay coil to explain the experimental observations. Compared with the model from electromagnetic field theory, which is complex and difficult to grasp, the circuit model proposed in this study is concise and easy to understand. Though the underwater WPT system has a relatively low average transfer efficiency of 20% at midrange, it can be used in a transfer distance priority scene.
Bison influences on composition and diversity of riparian plant communities in Yellowstone National Park
Authors: Kauffman J. Boone , Cummings Dian Lyn , Kauffman Cimarron , Beschta Robert L. , Brooks Jeremy , MacNeill Keeley , Ripple William J. 
Published: February 2023

AbstractRiparian zones are among the most biologically diverse ecosystems in the Intermountain West, USA, and provide valuable ecosystem services, including high rates of biotic productivity, nutrient processing, and carbon storage. Thus, their sustainability is a high priority for land managers. Large ungulates affect composition and structure of riparian/stream ecosystems through herbivory and physical effects, via trailing and trampling. Bison (Bison bison) in Yellowstone National Park (YNP) have been characterized as “ecosystem engineers” because of their demonstrated effects on phenology, aboveground productivity of grasses, and woody vegetation structure. Bison have greatly increased in numbers during the last two decades and spend large periods of time in the broad open floodplains of the Northern Range of the Park, where they are hypothesized to have multiple effects on plant species composition and diversity. We sampled indicators of bison use as well as riparian vegetation composition, diversity, and structure along eight headwater streams within YNP's Northern Range. Total fecal density ranged from 333 to 1833 fecal chips and/or piles/ha, stubble heights ranged from 7 to 49 cm, and streambank disturbance ranged from 9% to 62%. High levels of bison use were positively correlated with exotic species dominance and negatively correlated with species richness, native species diversity, willow (Salix spp.) cover, and wetland species dominance. At three sites, the intensity of bison use exceeded recommended utilization thresholds to avoid degradation of streams and riparian zones on public lands. The influences of large herbivores, principally bison, on vegetation composition and structure suggest the cumulative effects of the current densities on the Northern Range are contributing to biotic impoverishment, representing the loss of ecosystem services that are provided by native riparian plant communities. In addition, contemporary levels of bison use may be exacerbating climate change effects as observed through ungulate‐related shifts in composition toward plant assemblages adapted to warmer and drier conditions. However, the resilience of native riparian vegetation suggests that sites currently heavily utilized by bison would have the potential for recovery with a reduction in pressure by this herbivore.
Unique Thermal Structural Phase Transitions Exhibited by Unsymmetrical Organometallic Gold(III)‐Dithiolene Complexes with Pentylthio and Hexylthio Groups
Authors: Arata Sonomi , Kim Yuna , Hoshino Norihisa , Tahara Keishiro , Takahashi Kiyonori , Kadoya Tomofumi , Inoue Tomonori , Nakamura Takayoshi , Akutagawa Tomoyuki , Yamada Jun‐ichi , Kubo Kazuya 
Published: February 2023

AbstractUnsymmetrical gold(III)‐dithiolene complexes are potential candidates for molecular materials that exhibit thermal structural phase transitions. In this study, unsymmetrical ppy‐gold(III) (ppy−=C‐deprotonated‐2‐phenylpyridine(−)) complexes [AuC5] and [AuC6] coordinated by dithiolene ligands containing tetrathiafulvalene (TTF) skeletons with pentylthio (2‐{bis(pentylthio)‐1,3‐dithiol‐2‐ylidene}‐1,3‐dithiol‐4,5‐dithiolate(2−)) and hexylthio groups (2‐{bis(hexylthio)‐1,3‐dithiol‐2‐ylidene}‐1,3‐dithiol‐4,5‐dithiolate(2−)) were synthesized. Both complexes exhibited a large absorption band at approximately 508 nm, owing to intramolecular ligand‐to‐ligand charge transfer. One‐dimensional columnar structures with head‐to‐tail molecular arrangements around the metal ions were constructed in the crystals. The flexible alkylthio groups were intercalated into crystalline spaces between dithiolene ligands in the columns. [AuC5] exhibits a simple phase transition at 198 °C between crystalline and isotropic phases irreversibly. The crystalline phase of [AuC6] observed at 25 °C melted at 148 °C. Another crystalline phase grew above 148 °C with a very slow crystallization rate from the liquid phase and was completely transformed into an isotropic phase at 200 °C.
Boosting the Li|LAGP interfacial compatibility with trace nonflammable all‐fluorinated electrolyte: The role of solid electrolyte interphase
Authors: Liu Qi , Yu Jiahao , Guo Weiqian , Pan Yanfang , Han Cuiping , Liu Hong‐bo , Li Baohua 
Published: February 2023

AbstractNASCION‐type lithium (Li) conductors provide a great chance to break the challenges of solid‐state lithium batteries (SSLBs) emphasizing superior safety and high energy density. Nonetheless, their practical employment has been hampered by the poor interfacial compatibility. Herein, we successfully block interfacial side reactions by in situ constructing a LiF‐enrich solid electrolyte interphase (SEI) layer between Li metal and LAGP (Li1.5Al0.5Ge1.5(PO4)3) through dropping trace fluoroacetonitrile‐based all‐fluorinated electrolyte. Noted that the formed high Young's modulus but fast‐kinetics LiF‐rich SEI layer successfully suppresses growth of Li dendrite, further tailoring the superior interfacial chemistry. Consequently, such robust SEI upgrades critical current density of LAGP to a record‐high value of >1.5 mA cm−2. Furthermore, a hybride full cells assembled with the commercial‐level cathode deliver prominently cycling lifespan (>250 cycles) and outstanding rate performance. The present SEI engineering strategy enables a huge leap toward the industrialized deployments of SSLBs.image
Cross‐shore suspended sediment transport in a macro‐tidal and low‐sloping upper shoreface
Authors: Pezerat Marc , Bertin Xavier , Coulombier Thibault 
Published: February 2023

AbstractThe driving mechanisms of sediment transport across the upper shoreface have been poorly examined to date because of the scarcity of field measurements beyond the intertidal area, which is mainly due to instrumentation difficulties. Here, we investigate the cross‐shore suspended sediment transport from synchronized time series of bottom pressure, current velocity and suspended sediment concentration measured by 13 m water depth, in a macro‐tidal and low‐sloping shoreface, under storm waves and fair weather conditions. Depending on the tidal phase and the incoming wave height, the measuring structure was alternatively located in the shoaling zone and in the outer surf zone. The analysis of field observations first revealed that steady currents dominate suspended transport, with a notable contribution of the wave‐driven return current under storm wave conditions. Cross‐spectral analysis further indicates that short waves globally induce an offshore‐directed transport under energetic conditions associated with a crest‐to‐trough phase lag effect. The contribution of infragravity (IG) waves, which reaches as much as 20% of the total transport, shows contrasting directions depending on whether IG waves are bound to the short wave groups or propagate as free waves.
A Cross‐Shaped Monomer as Building Block for Molecular Textiles
Authors: Kroonen Camiel C. E. , D'Addio Adriano , Prescimone Alessandro , Fuhr Olaf , Fenske Dieter , Mayor Marcel 
Published: February 2023

AbstractThe exploration of new materials is timeless. Especially 2D‐materials have gotten much interest in the last decades. This work proposes a new route towards a fascinating class of 2D materials: molecular textiles. The suggested bottom‐up approach focuses on the 2D self‐assembly of a cross‐shaped monomer at the water/air interface. A 3D cross‐shaped motive was designed, synthesized, and characterized, which exhibits the required structural features, i. e., static and dynamic control. Analysis of the cross‐shaped motive by 1H‐NMR spectroscopy, X‐ray structure, and chiral stationary phase HPLC proved the rigidity and stability of the system, and thus also its potential for the here suggested new strategy towards molecular textiles. Three variants of a Schiff‐base precursor pair functionalized monomer were synthesized and characterized by 1H‐NMR spectroscopy, 13C‐NMR spectroscopy, and mass spectrometry. Finally, the network formation of the monomer is shown to be triggered by deprotonation of its ammonium salt, corroborated with FT‐IR analysis.