bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influence of conditioning regimen intensity on outcomes post‐allogeneic hematopoietic cell transplantation for acute myeloid leukemia in complete morphological remission
Authors: Alfaro Moya Tommy , Mattsson Jonas , Remberger Mats , Lipton Jeffrey H. , Kim Dennis D. , Viswabandya Auro , Kumar Rajat , Lam Wilson , Law Arjun D. , Gerbitz Armin , Pasic Ivan , Novitzky‐Basso Igor , Michelis Fotios V. 
Published: July 2023

AbstractIntroductionThe literature comparing outcomes between myeloablative (MAC) and reduced intensity conditioning (RIC) for acute myeloid leukemia (AML) is conflicting.MethodsWe retrospectively analyzed 451 patients who underwent allogenic hematopoietic cell transplantation (alloHCT) for AML in complete remission (CR) with either RIC (n = 331) or MAC (n = 120) with the use of dual T‐cell depletion as graft‐versus‐host disease (GVHD) prophylaxis.ResultsUnivariate analysis demonstrated nonrelapse mortality (NRM) at 2 years was 19.1% for MAC and 22.5% for RIC (p = .44). Two‐year cumulative incidence of relapse (CIR) was 19.8% for MAC and 24.5% for RIC (p = .15). Two‐year overall survival (OS) was 61% and 53% for MAC and RIC, respectively (p = .02). Two‐year graft‐versus‐host disease relapse‐free survival (GRFS) was 40.8% for MAC and 33.7% for RIC (p = .30).A propensity score‐matched analysis was done matching patients for age, HLA match, in vivo T‐cell depletion, and Disease Risk Index (DRI). Two‐year OS was 67% for MAC, 66% for RIC (p = .95). A subgroup analysis identified that matched related donor transplants benefit from MAC with OS at 2 years 82.6% versus 57.3% for RIC (p = .006).ConclusionsIn the matched‐related donor setting, MAC regimens may offer superior survival. Overall, for our cohort of predominantly in vivo T‐cell depleted patients the outcomes of MAC and RIC were similar.
High‐performance KNN piezoceramics with reproducibility and chemical stability. Part I: Solid‐state reaction route
Authors: Vaschalde Lucile , Víllora Encarnación G. , Shimamura Kiyoshi 
Published: July 2023

Abstract(K,Na)NbO3‐based compounds are attracting much attention for their high potential as Pb‐free piezoelectric ceramics. They have, however, three major drawbacks to overcome in order to achieve a mature development: densification, reproducibility, and chemical stability. In this first part, based on standard solid‐state reaction, the way to synthesize high‐density homogeneous ceramics with high piezoelectric performance and chemical stability is elucidated. It relies on a low‐temperature spark‐plasma sintering process, after the raw materials have been finely pulverized prior to reaction. The reproducibility, however, remains a pending issue due to the unavoidable random formation of parasitic phases.
Synergistic strengthening of aluminum with SiC by grain refinement and dispersion hardening
Authors: Nayak Kanhu C. , Han Juyeon , Park Suwon , Joo Miran , Lee Kon‐Bae , Bae Donghyun , Choi Hyunjoo 
Published: July 2023

AbstractThis study investigates the synergistic effect of SiCp on grain refinement and dispersion hardening in Al matrix composites produced by ball milling followed by hot rolling. Al grains are effectively refined by generating significant dislocations and subsequent dynamic recrystallization during milling. The presence of SiCp stimulates the grain refinement process by more effectively reducing the grain size to ∼40 nm. Furthermore, an increase in the milling speed and duration reduces the grain size and improves the dispersion of SiCp, thereby enhancing the yield strength without any significant loss of ductility. Consequently, SiCp/Al composites exhibit a tensile strength of 430.27 MPa with more than 4% of elongation before failure, indicating a strength enhancement of ∼325% compared to the unmilled pure Al counterpart.
Dietary wheat gluten induces astro‐ and microgliosis in the hypothalamus of male mice
Authors: Rizwan Mohammed Z. , Kerbus Romy , Kamstra Kaj , Keerthisinghe Pramuk , Tups Alexander 
Published: July 2023

AbstractGluten, which is found in cereals such as wheat, rye and barley, makes up a major dietary component in most western nations, and has been shown to promote body mass gain and peripheral inflammation in mice. In the current study, we investigated the impact of gluten on central inflammation that is typically associated with diet‐induced obesity. While we found no effect of gluten when added to a low‐fat diet (LFD), male mice fed high fat diet (HFD) enriched with gluten increased body mass and adiposity compared with mice fed HFD without gluten. We furthermore found that gluten, when added to the LFD, increases circulating C‐reactive protein levels. Gluten regardless of whether it was added to LFD or HFD led to a profound increase in the number of microglia and astrocytes in the arcuate nucleus of the hypothalamus, as detected by immunohistochemistry for ionised calcium binding adaptor molecule 1 (Iba‐1) and glial fibrillary acidic protein (GFAP), respectively. In mice fed LFD, gluten mimicked the immunogenic effects of HFD exposure and when added to HFD led to a further increase in the number of immunoreactive cells. Taken together, our results confirm a moderate obesogenic effect of gluten when fed to mice exposed to HFD and for the first‐time report gluten‐induced astro‐ and microgliosis suggesting the development of hypothalamic injury in rodents.
Cardiac electronic implantable devices: A call for a new coding system
Authors: Pereferrer Damià , Villuendas Roger , Bazan Victor , Sarrias Axel , Bisbal Felipe , Aranyo Júlia , Bayes‐Genís Antoni 
Published: July 2023

AbstractOver the last decades, cardiac electronic implantable devices (CEID) have incorporated a myriad of technological capabilities that are not conveniently inferred by using the conventional ICHD and NBG coding systems. We propose a new coding system (i.e., the C‐ARL‐A coding system) aimed at overcoming this important limitation.
Alternatives to transvenous lead placement in a patient undergoing surgical tricuspid valve repair
Authors: Zhu Angela , Rubinstein Matanyahu , Leet Angeline , Doi Atsuo , Patel Hitesh C 
Published: July 2023

AbstractTricuspid regurgitation is a widely recognised phenomenon in patients with transvenous cardiac rhythm management (CRM) devices. If tricuspid valve repair or replacement is to be considered, what to do with the existing CRM system requires scrutiny with multidisciplinary input. We present a case of multifactorial tricuspid regurgitation in a 48‐year‐old female with giant cell myocarditis and a transvenous implantable cardioverter‐defibrillator (ICD). Key considerations in management and alternative CRM options are discussed.
Energy-Efficient Tristable Soft Gripper Using Shape Memory Alloy Wires for Gripping Convex and Concave Objects
Authors: Jo Seon Mi , Yoon Hae-Sung 
Published: July 2023

Abstract
Bistable structures have been widely utilized in soft grippers to reduce the energy required for maintaining grip. Grippers have been investigated in terms of the energy efficiency and accuracy of gripping; however, the limited number of gripping states hinders the holding of objects of various shapes. In this study, an energy-efficient gripper was developed to accommodate both convex and concave shapes using a tristable structure that combines two bistable structures, with shape memory alloy wires used as actuators. Different gripping modes were designed for convex and concave shapes, based on three states of the gripper: gripping, open, and holding. The gripper consisted of a driving part with a leaf spring for a “linear snap action” and a soft finger part with an elastic ring and prestressed fingers. Geometric variables were adjusted to construct a tristable energy curve through experiments and analyses. The fabricated gripper weighed about 140 g and was capable of gripping convex objects of up to 80 g, and concave objects of about 120 g. Only a small amount of energy was consumed in the switching states, and the gripper maintained a stable state while gripping with no energy consumption. It is expected that this research will contribute to lightweight and energy-efficient grippers for application to drones, for example.
A Screening Method for Retired Lithium-Ion Batteries Based on Support Vector Machine With a Multi-Class Kernel Function
Authors: Qiang Hao , Liu Yuanlin , Zhang Wanjie 
Published: July 2023

Abstract
With the retirement of a large number of lithium-ion batteries from electric vehicles, their reuse has received increasing attention. However, a retired battery pack is not suitable for direct reuse due to the poor consistency of in-pack batteries. This paper proposes a method of retired lithium-ion battery screening based on support vector machine (SVM) with a multi-class kernel function. First, ten new NCR18650B batteries were used to carry out the aging experiments for collecting the main parameters, such as capacity, voltage, and direct current resistance. Second, an SVM based on a multi-class kernel function was proposed to screen retired batteries. To improve the screening efficiency, a capacity/voltage second-order conductance curve was adopted to extract their capacity features quickly, and four new feature points were selected as the input of the SVM to classify retired batteries. Finally, the retired batteries are accurately divided into four classes by the trained model, and the classification accuracy can reach 97.0%. Compared with the traditional method, the feature extraction time can be reduced by four-fifths, and the screening efficiency is greatly improved.
Front Matter
Authors: Matthews Clifford 
Published: July 2023

This frontmatter contains the Contents, Acknowledgements, Preface. It is available for access by clicking on the PDF icon below.
eBook keywords: API 510, API 570, API 653, API Bodies of Knowledge, ICP exam, API codes, welding inspection, welding processes, NDE requirements, ASME IX, inspection pipe flanges, process piping.
Monocrystalline Silicon PERC Solar Cell with Rear-Side AlOx Film Formed by Furnace Oxidation
Authors: Hsu Ching-Hui , Lao Da-Yao , Wang Likarn 
Published: July 2023

In this study, AlOx passivation layers on the rear sides of silicon PERC solar cells are formed by thermally oxidizing 3 nm-thick aluminum films deposited in advance by an e-gun evaporator. The oxidation process is conducted in a furnace full of oxygen at 400°C for a duration of 10 minutes, followed by annealing for a duration of 3 minutes at 700°C, and then the stacking of SiNx films on the back surfaces. After that, a second annealing process is done at 400°C for a duration of 10 minutes to repair the defects resulting from the bombardment of ions on the passivation layer. With the thermal oxidation method applied, we confirmed the existence of an AlOx passivation layer with a negative charge density of

−
3.21
×

10

12

cm-2 for an annealed sample, in contrast to

−
6.17
×

10

11

cm-2 for an unannealed sample.
Applications of molecular markers in taxonomic identification of Araceae species from Vietnam – A short review
Authors: Van Hong Thien , Nguyen-Phi Nga , Luu Hong Truong 
Published: July 2023

Abstract
Araceae is a large family widely distributed worldwide, especially in tropical and subtropical regions. Members of Araceae have a characteristic inflorescence and they also possess various morphologies. There were many taxonomic confusions based on the botanist's views on the taxonomic status of Araceae members. This review provides information about application of molecular markers in studying taxonomy of the Araceae species, especially in Vietnam. Furthermore, it includes illustrative photos of all aroids species in Vietnam identified using molecular markers.
The Osaka prognostic score and Naples prognostic score: novel biomarkers for predicting short-term outcomes after spontaneous intracerebral hemorrhage
Authors: Liu Rui , Chen Changcun , Zhao Yutong , Tang Yuguang , Shen Weiwei , Xie Zongyi 
Published: July 2023

Abstract
Objectives
Poor immune-nutritional status has been associated with an unfavorable outcome in critical illness. The Osaka prognostic score (OPS) and the Naples prognostic score (NPS), based on inflammatory and nutritional status, has been shown to predict prognosis following cancer and other diseases. The aim of this study was to investigate the relationship between the OPS and NPS and the short-term outcomes of patients with intracerebral hemorrhage (ICH).

Methods
We retrospectively analyzed the clinical data of patients hospitalized with spontaneous ICH (n = 340) at The Second Affiliated Hospital of Chongqing Medical University between August 2016 and August 2021. Inclusion criteria included patients aged between 18 and 70, and if a blood sample was taken for laboratory testing within 24 h of admission (serum C-reactive protein, albumin, total cholesterol, and counts for neutrophils, lymphocytes, and monocytes were collected on admission). Exclusion criteria included a non-spontaneous cause of ICH and patient death during hospitalization. Patients were divided into four groups based on OPS or five groups according to NPS. Outcomes were evaluated by the modified Rankin Scale (mRS) at six months post-ICH hospitalization. An unfavorable outcome was defined as a mRS score ≥ 3.

Results
A total of 289 patients met our inclusion criteria. The unfavorable outcome group had older age, a lower Glasgow Coma Scale score, a higher rate of complications and cerebral herniation, a longer hospital stay, and higher OPS and NPS when compared with the favorable outcome group. Univariate analysis showed that both OPS and NPS were strongly correlated with mRS (r = 0.196,P < 0.001; r = 0.244, P = 0.001, respectively). Multivariate analysis further showed that OPS and NPS were both independent predictors of unfavorable outcomes for patients with ICH with adjusted odds ratios of 1.802 (95% confidence interval [CI]:1.140–2.847, P = 0.012) and 1.702 (95% CI: 1.225–2.635, P = 0.02), respectively. The area under the curve (AUC) of NPS for predicting a poor outcome was 0.732 (95% CI: 0.665–0.799), which was similar to the AUC of OPS 0.724 (95% CI: 0.657–0.792).

Conclusions
In this cohort, a higher OPS and NPS on admission was associated with poor outcome at six months following ICH, supporting their potential role as markers for predicting the outcome of patients with ICH.
Sintilimab plus bevacizumab and CapeOx (BBCAPX) on first-line treatment in patients with RAS mutant, microsatellite stable, metastatic colorectal cancer: study protocol of a randomized, open-label, multicentric study
Authors: Fang Xuefeng , Zhong Chenhan , Weng Shanshan , Hu Hanguang , Wang Jian , Xiao Qian , Wang Jianwei , Sun Lifeng , Xu Dong , Liao Xiujun , Dong Caixia , Zhang Suzhan , Li Jun , Ding Kefeng , Yuan Ying 
Published: July 2023

Abstract
Background
Rat sarcoma viral oncogene homolog (RAS) gene mutation is a common molecular event in colorectal cancer (CRC). The prognosis of mCRC (metastatic colorectal cancer) patients with RAS mutation is poor and capecitabine and oxaliplatin (CapeOx) plus bevacizumab has shown to be one of the standard therapeutic regimens as first line for these patients with objective response rate (ORR) of ~ 50% and median progression-free survival (mPFS) of 8–9 months. Immunotherapy, especially anti-programmed death 1 (PD-1) monoclonal antibody has demonstrated ground-breaking results in deficient mismatch repair (dMMR) / microsatellite instability-high (MSI-H) mCRC patients. However, the response rate of in microsatellite stable (MSS) patients is extremely low. In addition, preclinical studies have demonstrated that anti-Vascular endothelial growth factor (VEGF) agents, such as bevacizumab, can induce tumor vascular normalization and enhance antitumor immunity. Previous study indicated the combination of chemotherapy, anti-VEGF agents (bevacizumab) with immune checkpoint inhibitors may have promising clinical activity in RAS mutant, MSS refractory mCRC patients. Based on these evidences, we will explore the combination of CapeOx with bevacizumab and sintilimab (anti-PD-1 monoclonal antibody) in RAS mutant, MSS mCRC patients as first-line therapy.

Methods
This is a randomized, open-label, multicentric clinical trial. In the sintilimab arm, patients will receive sintilimab in combination with CapeOx and bevacizumab. In the control arm, patients will receive CapeOx and bevacizumab. This trial will recruit 494 patients from 20 centers and randomly (1:1) disseminated into two groups. The primary endpoint is the PFS. The secondary endpoints include overall survival, safety, ORR, and disease control rate.

Discussion
This study may provide new ideas for optimizing oncology treatment planning for RAS mutant, MSS mCRC patients in the first-line set.

Trial registration
This study is short for BBCAPX and has been registered at clinicaltrials.gov registry with identifier NCT05171660.
Evaluating the Efficacy of Connected Healthcare: An Empirical Examination of Patient Engagement Approaches and Their Impact on Readmission
Authors: Lekwijit Suparerk , Terwiesch Christian , Asch David A. , Volpp Kevin G. 
Published: July 2023

Connected healthcare is a form of health delivery that connects patients and providers through connected health devices, allowing providers to monitor patient behavior and proactively intervene before an adverse event occurs. Unlike the costs, the benefits of connected healthcare in improving patient behavior and health outcomes are usually difficult to determine. In this study, we examine the efficacy of a connected health system that aimed to reduce readmissions through improved medication adherence. Specifically, we study 975 patients with heart disease who received electronic pill bottles that tracked medication adherence. Patients who were nonadherent received active social support that involved different types of feedback, such as text messages and calls. By integrating data on adherence, intervention, and readmission, we aim to (1) investigate the efficacy of connected healthcare in promoting medication adherence, (2) examine the relationship between medication adherence and readmission, and (3) develop a dynamic readmission risk-scoring model that considers medication adherence and use the model to better target nonadherent patients. Our findings suggest that patients are more likely to become adherent when they or their partners receive high levels of intervention that involve personalized feedback and when the intervention is escalated quickly and consistently. We also find that long-term adherence to three common heart medications is strongly associated with reduced readmission risk. Lastly, using counterfactual simulation, we apply the dynamic readmission risk-scoring model to our setting and find that, when using an intervention strategy that prioritizes high-risk patients, we obtain 10% fewer readmissions while using the same effort level from the patient support team. This paper was accepted by Jayashankar Swaminathan, operations management. Funding: The randomized, controlled trial was funded by the Center for Medicare & Medicaid Innovation [Healthcare Innovation Award 1C1CMS331009]. Supplemental Material: The data files are available at https://doi.org/10.1287/mnsc.2023.4865 .
Association Between Anxiety/Depression and Gastroesophageal Reflux: A Systematic Review and Meta-Analysis
Authors: Zamani Mohammad , Alizadeh-Tabari Shaghayegh , Chan Walter W. , Talley Nicholas J. 
Published: July 2023

INTRODUCTION:An association between gastroesophageal reflux disease (GERD) and common psychiatric conditions, most notably anxiety and depression, has been reported. However, the magnitude of this association is poorly understood. Therefore, we aimed to systematically assess this issue.METHODS:We comprehensively searched multiple bibliographic databases (Embase, PubMed, Scopus, and Web of Science) from inception to May 15, 2023. We retrieved observational studies that reported the prevalence of anxiety and/or depressive symptoms diagnosed by validated questionnaires in ≥100 adults (aged 18 years or older) with GERD. We also included cohort studies that explored the risk of incident GERD in subjects with anxiety/depression vice versa scenario. Finally, we included Mendelian randomization studies that assessed the cause-and-effect relationship between anxiety/depression and GERD. The extracted data were combined using a random-effects model.RESULTS:In total, 36 eligible studies were included. The pooled prevalences of anxiety and depressive symptoms were 34.4% (95% confidence interval [CI] 24.7–44.2;I2= 99.4%) and 24.2% (95% CI 19.9–28.5;I2= 98.8%) in subjects with GERD based on 30 studies, respectively. Both anxiety and depressive symptoms were more common in subjects with GERD compared with those in healthy controls (odds ratio = 4.46 [95% CI 1.94–10.25] and odds ratio = 2.56 [95% CI 1.11–5.87], respectively). According to 3 cohort studies, subjects with GERD were at an increased risk of developing anxiety/depression and vice versa. Finally, 3 Mendelian randomization studies showed that genetic liability to these mood disorders is linked to an increased risk of developing GERD and vice versa.DISCUSSION:Up to 1 in 3 subjects with GERD experience anxiety and depression. There is likely a bidirectional causal relationship between anxiety/depression and GERD.
Genetic alterations of KRAS and TP53 in intrahepatic cholangiocarcinoma associated with poor prognosis
Authors: Peng Jianbo , Fang Shuo , Li Meisheng , Liu Yuxin , Liang Xiaolu , Li Zuobiao , Chen Gaohui , Peng Lijiao , Chen Nianping , Liu Lei , Xu Xiaohong , Dai Wei 
Published: July 2023

Abstract
The aim of this study is to investigate certain genetic features of intrahepatic cholangiocarcinoma (ICCA). A total of 12 eligible ICCA patients were enrolled, and tumor tissues from the patients were subjected to next-generation sequencing of a multi-genes panel. Tumor mutation burden (TMB), mutated genes, copy number variants (CNVs), and pathway enrichment analysis were performed. The median TMB was 2.76 Mutation/Mb (range, 0–36.62 Mutation/Mb) in ICCA patients. The top two most commonly mutated genes in ICCA were KRAS (33%) and TP53 (25%). The co-mutations of KRAS and TP53 were 16.7% (2/12) in ICCA patients. Notably, patient P6 with the highest TMB did not have KRAS and TP53 mutations. Additionally, TP53 and/or KRAS alterations were significantly associated with poor progression-free survival than those with wild type (1.4 months vs 18 months). DNA damage repair and homologs recombinant repair deficiencies were significantly associated with high TMB in ICCA cases. In conclusion, we found that certain genetic mutations of TP53 and KRAS could predict poor prognosis in ICCA patients.
Vowel harmony in Rma: a diachronic perspective
Authors: Sims Nathaniel A. 
Published: July 2023

AbstractThis paper looks at the vowel harmony system of Ronghong Rma (Qiang). This system has previously been described in terms of synchronic vowel alternations. This paper takes a different approach to explore the diachronic element of vowel harmony. The finding is that ‘harmonization’ is epiphenomenal and that the vowel alternations are the results of regular sound changes from an earlier stage in the language. This diachronic perspective brings into focus a chain shift in the vowel system and clarifies the etymologies of forms that have undergone these changes. It also reveals the importance of uvular consonants as conditioning environments for vowel changes in Ronghong Rma.