bluuebunny/crossref_metadata_2025_split huggingface dataset:
Induction of Metabolic Reprogramming in Kidney by Singlet Diradical Nanoparticles
Authors: Ye Lei , Jiang Shengwei , Hu Jinlian , Wang Mingzhe , Weng Taoyu , Wu Feng , Cai Liangyu , Sun Zhe , Ma Lan 
Published: June 2023

AbstractPolycyclic aromatic compounds with an open‐shell singlet diradical ground state, namely singlet diradicals, have recently gained attention in the fields of organic electronics, photovoltaics, and spintronics owing to their unique electronic structures and properties. Notably, singlet diradicals exhibit tunable redox amphoterism, which makes them excellent redox‐active materials for biomedical applications. However, the safety and therapeutic efficacy of singlet diradicals in biological systems have not yet been explored. Herein, the study presents a newly designed singlet diradical nanomaterial, diphenyl‐substituted biolympicenylidene (BO‐Ph), exhibiting low cytotoxicity in vitro, non‐significant acute nephrotoxicity in vivo, and the ability to induce metabolic reprogramming in kidney organoids. Integrated transcriptome and metabolome analyses reveal that the metabolism of BO‐Ph stimulates glutathione (GSH) synthesis and fatty acid degradation, increases the levels of intermediates in the tricarboxylic acid (TCA) and carnitine cycles, and eventually boosts oxidative phosphorylation (OXPHOS) under redox homeostasis. Benefits of BO‐Ph‐induce metabolic reprogramming in kidney organoids include enhancing cellular antioxidant capacity and promoting mitochondrial function. The results of this study can facilitate the application of singlet diradical materials in the treatment of clinical conditions induced by mitochondrial abnormalities in kidney.
Exchange‐Interaction‐Like Behavior in Ferroelectric Bilayers
Authors: Kavle Pravin , Ross Aiden M. , Zorn Jacob A. , Behera Piush , Parsonnet Eric , Huang Xiaoxi , Lin Ching‐Che , Caretta Lucas , Chen Long‐Qing , Martin Lane W. 
Published: June 2023

AbstractInterlayer coupling in materials, such as exchange interactions at the interface between an antiferromagnet and a ferromagnet, can produce exotic phenomena not present in the parent materials. While such interfacial coupling in magnetic systems is widely studied, there is considerably less work on analogous electric counterparts (i.e., akin to electric “exchange‐bias‐like” or “exchange‐spring‐like” interactions between two polar materials) despite the likelihood that such effects can also engender new features associated with anisotropic electric dipole alignment. Here, electric analogs of such exchange interactions are reported, and their physical origins are explained for bilayers of in‐plane polarized Pb1−xSrxTiO3 ferroelectrics. Variation of the strontium content and thickness of the layers provides for deterministic control over the switching properties of the bilayer system resulting in phenomena analogous to an exchange‐spring interaction and, leveraging added control of these interactions with an electric field, the ability to realize multistate‐memory function. Such observations not only hold technological promise for ferroelectrics and multiferroics but also extend the similarities between ferromagnetic and ferroelectric materials to include the manifestation of exchange‐interaction‐like phenomena.
Temperature Decoupling of a Hydrogel‐Based Strain Sensor under a Dynamic Temperature Field
Authors: Li Zemin , Huang Jiaoya , Zhou Runhui , Chen Ziyu , Gao Wenchao , He Jiang , Bao Rongrong , Pan Caofeng 
Published: June 2023

AbstractHydrogels possess several interesting characteristics and have attracted increasing attention for flexible interactive strain‐sensing. However, hydrogel strain sensors are easily influenced by temperature because of the intrinsic characteristics of the materials, thus, their sensing accuracy is significantly affected. Herein, a strategy is proposed to eliminate the influence of temperature by building an in‐situ hydrogel temperature sensor next to the strain sensor to monitor ambient temperature changes and simultaneously correct the strain signal. By introducing silicon nanoparticles and modified graphene, the hydrogel exhibits a good balance between conductivity and stretchability. The hydrogel strain sensor exhibits a working range of up to 1000% and a sensitivity of 8.1. It can monitor human movement and shows good stability. Moreover, the hydrogel‐based sensor demonstrates an impressive thermal response sensitivity (−7.16% °C−1). This bimodal sensor not only realizes the decoupling of the strain sensor from the temperature but protects the temperature sensor from the influence of strain. More importantly, the device is also able to accurately control the manipulator under dynamic temperatures, proving the feasibility of the design. This strategy provides a new method to eliminate the influence of temperature on strain sensing and assists in the development of the interactive‐sensing field.
Dynamically Tunable Structural Colors Enabled by Pixelated Programming of Soft Materials on Thickness
Authors: Huang Mengting , Wang Yifei , Liu Xuan , Zhang Songyu , Yuan Cong‐Long , Hu Hong‐Long , Zheng Zhi‐Gang 
Published: June 2023

AbstractStructural colors are widespread in nature and have become an important component of the lives. Considerable efforts have been made toward reversible color tuning, which underpins intriguing applications, including color displays, anti‐counterfeiting, and information encryption. However, the limited size, complicated fabrication processes, and low modulation speeds of structural colors are the main obstacles to their further development. Herein, a facile method to realize dynamically tunable structural colors is presented, which are enabled by the pixelated programming of soft materials on thickness. Pixelated photoresist microarrays with different heights are obtained using a digitalized lithography technique, enabling delicate control over the thickness of the liquid crystal (LC) layers. Stimuli‐responsive LCs endow structural colors with dynamic and reversible tunability and exhibit remarkable switching speeds with external stimuli. The proposed strategy sheds new light on dynamically tunable structural colors and promotes the development of optical anti‐counterfeiting, thermal sensors, and advanced information encryption.
Metasurface‐Based Free‐Space Multi‐Port Beam Splitter with Arbitrary Power Ratio
Authors: Tian Tian , Liao Yuxuan , Feng Xue , Cui Kaiyu , Liu Fang , Zhang Wei , Huang Yidong 
Published: June 2023

AbstractA beam splitter (BS) is one of the most critical building blocks in optical systems. Despite various attempts of flat‐type BSs to miniaturize the conventional cube BS reported, it remains a challenge to realize an ultrathin optical BS with multi‐port output, non‐uniform splitting ratio, and steerable outgoing directions. Herein, a free‐space optical multi‐port beam splitter (MPBS) based on a polarization‐independent all‐dielectric metasurface is demonstrated. By applying an optimized phase‐pattern paradigm via a gradient‐descent‐based iterative algorithm to amorphous silicon (α‐Si) metasurfaces, a variety of MPBS samples with arbitrarily predetermined output port number (2–7), power ratio, and spatial distribution of output beams are prepared. The experimental results reveal that the fabricated MPBSs can achieve high total splitting efficiency (TSE, above 74.7%) and beam‐splitting fidelity (similarity, above 78.4%) within the bandwidth of 100 nm (1500–1600 nm). Such proposed MPBS can provide fabulous flexibility for optical integrated system and diverse applications.
Copper‐Catalyzed C(sp3)− Functionalization and Annulation of 2‐Bromoaryl Oximes with Active Methylene Compounds towards Synthesis of Isoquinoline N‐Oxides
Authors: Patel Chandresh K. , Gujjarappa Raghuram , Kant Kamal , Ghanta Susanta , Singh Virender , Kabi Arup K. , Al‐Zaqri Nabil , Malakar Chandi C. 
Published: June 2023

AbstractThe established process proceeds through copper (II)‐catalyzed C(sp3)− functionalization of β‐diketones/β‐ketoesters with 2‐bromobenzaldehyde oximes followed by the intramolecular cyclization of in situ generated acylated intermediates to deliver isoquinoline N‐oxides. The copper(II) acetate catalyzed C−H functionalization showed maximum efficacy at 60 °C in methanol/toluene as solvent. The described reaction conditions were applicable over a wide range of substrates with a variety of functional groups to yield isoquinoline N‐oxides in yields up to 85%. The developed approach was further elucidated by means of control experiments and DFT calculations.
Computational Insights into the Reactivity Difference between Hypervalent Bromine(III) and Hypervalent Iodine(III) Reagent in the C−H Amination and Alkene Aziridination
Authors: Shao Yingbo , Ren Zhiyuan , Zheng Chenfengtao , Xue Xiao‐Song 
Published: June 2023

AbstractWe present herein a computational exploration into the mechanism and origin of the reactivity difference between N‐triflylimino‐λ3‐iodane and N‐triflylimino‐λ3‐bromane in the C−H amination and alkene aziridination. Our calculations revealed that the preferred mechanism for C−H amination involves the generation of free nitrene intermediate, while the alkene aziridination proceeds via a concerted reaction mechanism. The superior reactivity of N‐triflylimino‐λ3‐bromane over N‐triflylimino‐λ3‐iodane could be mainly ascribed to better nucleofugality of the bromanyl moiety, which can be characterized by the strength of I−N and Br−N bond. The effect of solvent polarity on the reactivity of N‐triflylimino‐λ3‐bromane as a nitrene precursor will be discussed.
Top‐down kinetic modeling from power law to elementary steps using KASTER: A methane steam reforming case study
Authors: Siradze Sébastien , Poissonnier Jeroen , Costa da Cruz Ana R. , Thybaut Joris W. 
Published: June 2023

AbstractA top‐down methodology for kinetic model construction including regression against experimental data is proposed using “KASTER.” As a case study, it is applied in the assessment of methane steam reforming (MSR) including water–gas shift (WGS) on a Ni catalyst at 923 K. The degree of detail in the reaction mechanism and the corresponding model is gradually enhanced, typically ranging from a simple power law to a microkinetic model. The reactor equations are solved transiently, preventing the numerical challenges encountered in the steady‐state solution, particularly for microkinetic models. The microkinetic variant indicated that CH4 dissociative adsorption and CO formation are kinetically relevant steps in MSR, while COOH formation is rate‐determining in WGS. However, the model providing the best balance between detail accounted for and parameter significance corresponded to a Langmuir–Hinshelwood–Hougen–Watson (LHHW) mechanism accounting for dissociative adsorption, with CO formation and COOH formation as rate‐determining steps for MSR and WGS, respectively.
Exome sequencing in a Romanian Bardet‐Biedl syndrome cohort revealed an overabundance of causal BBS12 variants
Authors: Khan Sheraz , Focșa Ina Ofelia , Budișteanu Magdalena , Stoica Cristina , Nedelea Florina , Bohîlțea Laurențiu , Caba Lavinia , Butnariu Lăcrămioara , Pânzaru Monica , Rusu Cristina , Jurcă Claudia , Chirita‐Emandi Adela , Bănescu Claudia , Abbas Wasim , Sadeghpour Azita , Baig Shahid Mahmood , Bălgrădean Mihaela , Davis Erica E. 
Published: June 2023

AbstractBardet‐Biedl syndrome (BBS), is an emblematic ciliopathy hallmarked by pleiotropy, phenotype variability, and extensive genetic heterogeneity. BBS is a rare (~1/140,000 to ~1/160,000 in Europe) autosomal recessive pediatric disorder characterized by retinal degeneration, truncal obesity, polydactyly, cognitive impairment, renal dysfunction, and hypogonadism. Twenty‐eight genes involved in ciliary structure or function have been implicated in BBS, and explain the molecular basis for ~75%–80% of individuals. To investigate the mutational spectrum of BBS in Romania, we ascertained a cohort of 24 individuals in 23 families. Following informed consent, we performed proband exome sequencing (ES). We detected 17 different putative disease‐causing single nucleotide variants or small insertion–deletions and two pathogenic exon disruptive copy number variants in known BBS genes in 17 pedigrees. The most frequently impacted genes were BBS12 (35%), followed by BBS4, BBS7, and BBS10 (9% each) and BBS1, BBS2, and BBS5 (4% each). Homozygous BBS12 p.Arg355* variants were present in seven pedigrees of both Eastern European and Romani origin. Our data show that although the diagnostic rate of BBS in Romania is likely consistent with other worldwide cohorts (74%), we observed a unique distribution of causal BBS genes, including overrepresentation of BBS12 due to a recurrent nonsense variant, that has implications for regional diagnostics.
The effect of reference sample composition and size on dental age interval estimates
Authors: Sgheiza Valerie , Liversidge Helen M. 
Published: June 2023

AbstractObjectivesValidation studies in juvenile dental age estimation primarily focus on point estimates while interval performance for reference samples of different ancestry group compositions has received minimal attention. We tested the effect of reference sample size and composition by sex and ancestry group on age interval estimates.Materials and MethodsThe dataset consisted of Moorrees et al. dental scores from panoramic radiographs of 3334 London children of Bangladeshi and European ancestry and 2–23 years of age. Model stability was assessed using standard error of mean age‐at‐transition for univariate cumulative probit and sample size, group mixing (sex or ancestry), and staging system as factors. Age estimation performance was tested using molar reference samples of four sizes, stratified by year of age, sex, and ancestry. Age estimates were performed using Bayesian multivariate cumulative probit with 5‐fold cross‐validation.ResultsStandard error increased with decreasing sample size but showed no effect from mixing by sex or ancestry. Estimating ages using a reference and target sample of different sex reduced success rate significantly. The same test by ancestry groups had a lesser effect. Small sample size (n < 20/year of age) negatively affected most performance metrics.DiscussionWe found that reference sample size, followed by sex, primarily drove age estimation performance. Combining reference samples by ancestry produced equivalent or better estimates of age by all metrics than using a single‐demographic reference of smaller size. We further proposed that population specificity is an alternative hypothesis of intergroup difference that has been erroneously treated as a null.
Nickel‐Catalyzed Markovnikov‐Selective Hydrodifluoromethylation of Alkynes Using BrCF2H
Authors: Pan Shiwei , Chen Fan , Zhang Yanyan , Shao Liang , Chu Lingling 
Published: June 2023

AbstractA Markovnikov‐selective hydrodifluoromethylation of alkynes with BrCF2H via nickel catalysis is described. This protocol proceeds via a migratory insertion of nickel hydride to alkyne followed by a CF2H‐coupling, enabling straightforward access to diverse branched CF2H‐alkenes with high efficiency and exclusive regioselectivity. The mild condition applies to a wide array of aliphatic and aryl alkynes with good functional group compatibility. Mechanistic studies are presented to support the proposed pathway.
A review of the desert gold jojoba (Simmondsia chinensis) whole plant, oil, and meal: Phytochemical composition, medicinal uses, and detoxification
Authors: El Gendy Salsabeel N. , Elmotayam Amira K. , Samir Reham , Ezzat Marwa I. , El Sayed Aly M. 
Published: June 2023

AbstractSimmondsia chinensis (Link) C.K. Schneider (Jojoba) is a valuable shrub that can bear harsh conditions and is cultivated in many countries globally. Its prominence originates from the unique oil that constitutes more than 50% of the seeds. The great economic value of jojoba oil is highlighted in many fields, especially the cosmetic industry. The remaining meal, which is rich in proteins, constitutes a good source for cattle feeding. However, the presence of antinutritional principles in the meal limited its use and encouraged the researchers to find different ways for its detoxification. The detoxification ways of jojoba meal included physical, biological, and chemical treatments. The phytochemical composition of the oil was deeply studied, but for the remaining plant, only few studies have reported its chemical composition. Jojoba oil composed of wax esters (97%), fatty acids, fatty alcohols, sterols, and small percentage of vitamin E. Jojoba possesses a long traditional history. It has been used in folklore for treatment of cold, dysuria, and obesity. Many recent studies reported its medicinal and pharmacological properties like antioxidant, anti‐inflammatory, antimicrobial, anticancer, anti‐acne, anti‐psoriasis, wound healing, and hepatoprotective activities. Many of these biological activities have been attributed to the presence of several phytochemicals such as simmondsin and phenolic compounds. In this review, the authors will highlight the previous phytochemical studies, medicinal applications of jojoba oil and different plant parts, and the various ways of meal detoxification.
Transcriptome profiling research in urothelial cell carcinoma
Authors: Ahmad Umar , Ibrahim Buhari , Mohammed Mustapha , Aldoghachi Ahmed Faris , Usman Mahmood , Yakubu Abdulbasit Haliru , Tanko Abubakar Sadiq , Bobbo Khadijat Abubakar , Garkuwa Usman Adamu , Faggo Abdullahi Adamu , Mustapha Sagir , Al‐Masaeed Mahmoud , Abdullah Syahril , Keong Yong Yoke , Veerakumarasivam Abhi 
Published: June 2023

AbstractUrothelial cell carcinoma (UCC) is the ninth most common cancer that accounts for 4.7% of all new cancer cases globally. UCC development and progression are due to complex and stochastic genetic programs. To study the cascades of molecular events underlying the poor prognosis that may lead to limited treatment options for advanced disease and resistance to conventional therapies in UCC, transcriptomics technology (RNA‐Seq), a method of analyzing the RNA content of a sample using modern high‐throughput sequencing platforms has been employed. Here, we review the principles of RNA‐Seq technology and summarize recent studies on human bladder cancer that employed this technique to unravel the pathogenesis of the disease, identify biomarkers, discover pathways and classify the disease state. We list the commonly used computational platforms and software that are publicly available for RNA‐Seq analysis. Moreover, we discussed the future perspectives for RNA‐Seq studies on bladder cancer and recommended the application of a new technology called single‐cell sequencing to further understand the disease.
Metadata as imaginary demands: Exploring metadata markets in digital heritage with speculative design
Authors: Hansson Karin 
Published: June 2023

AbstractCultural heritage practices is formed by different socio‐technical regimes. Today, it is increasingly formed by the regime of commodification, expressed in terms like interoperability and reuse. This signifies a shift from a regime of the authentic object where the value is in the unique object positioned in a particular institutional context. To be able to exploit cultural heritage items on digital markets detached from their position in their original context, large resources are needed to furnish the items with metadata. In this metadata production, the regime of the institution as guarantor for the objects' authenticity, clash with the regime of aggregated trust, where authenticity is confirmed by aggregating data from multiple producers. This article argue that such rich contextual information is what creates long‐term value for digital archival objects. In this speculative design project focusing humanities research needs, I therefore turn the attention to the metadata producers. Taking the idea of metadata as a commodity to its peak, I show how we can interpret metadata as a supply to meet imaginary demands. By looking at metadata as imaginary demands we can begin to see the contours of the diverse conceptual models the archives carry.
Bimetallic hydrogels based on chitosan and carrageenan as promising materials for biological applications
Authors: Khalil Ahmed M. , Hashem Amr H. , Kamel Samir 
Published: June 2023

AbstractIn this study, novel crosslinked hydrogels based on chitosan (CS) and carrageenan (CRG) loaded with silver and/or copper nanoparticles (Ag/CuNPs) were prepared through a freeze‐drying (thawing) process to be applied in biological applications comprising wound dressing. These hydrogels showed porous interconnected structures. The influence of the used nanoparticles (NPs) on the antibacterial properties of the CS/CRG hydrogels was explored. Antimicrobial results revealed that both CS/CRG/CuNPs, CS/CRG/AgNPs, and CS/CRG/Ag‐CuNPs exhibited promising antibacterial and antifungal activity against Escherichia coli, Pseudomonas aeruginosa, Streptococcus mutans, Staphylococcus aureus, Bacillus subtilis, and Candida albicans. Moreover, CS/CRG/AgNPs, CS/CRG/CuNPs, and CS/CRG/Ag‐CuNPs hydrogels showed potential antioxidant activity to be 57%, 78%, and 89%, respectively. Furthermore, cytotoxicity results against Vero normal cell line confirmed that all designed hydrogels are safe upon usage. The bimetallic CS/CRG hydrogels showed notably enhanced antibacterial properties among the as‐prepared hydrogels allowing them to be a successful material upon being employed in wound dressing applications.
Current status of platelet manufacturing in 3D or bioreactors
Authors: Kweon Soonho , Kim Suyeon , Choi Hye Sook , Jo Kyeongwon , Park Ju Mi , Baek Eun Jung 
Published: June 2023

AbstractBlood shortages for transfusion are global issues of grave concern. As in vitro manufactured platelets are promising substitutes for blood donation, recent research has shown progresses including different cell sources, different bioreactors, and three‐dimensional materials. The first‐in‐human clinical trial of cultured platelets using induced pluripotent stem cell‐derived platelets began in Japan and demonstrated its quality, safety, and efficacy. A novel bioreactor with fluid motion for platelet production has been reported. Herein, we discuss various cell sources for blood cell production, recent advances in manufacturing processes, and clinical applications of cultured blood.
Design, Characterization and Evaluation of a Lab‐made Photoreactor: A First Step Towards Standardized Procedures in Photocatalysis**
Authors: Aubineau Thomas , Laurent Justine , Olanier Ludovic , Guérinot Amandine 
Published: June 2023

AbstractFor the last fifteen years, photochemistry has known a renewal with the emergence of new photoredox approaches, along with the development of new powerful artificial sources of light. However, the described procedures often lack information about the characteristics of the setups (wavelength, actual received light power, distance from the source) even when commercial apparatuses are used. This lacunar information hampers the development of standardized procedures which would guarantee the reproducibility of the reactions. With the objective of furnishing a standardized setup, a lab‐made reactor was designed. The use of 3D‐printing technology makes it easily accessible to most laboratories. Its characterization showed the critical effect of the environmental conditions upon the light power received and how crucial they are for reproducibility of photochemical reactions. At last, the setup was evaluated against experiments taken from recent literature.