bluuebunny/crossref_metadata_2025_split huggingface dataset:
Immediate and long-term results of the treatment of patients with rectal cancer
Authors: Kit O. I. , Gevorkyan Yu. A. , Soldatkina N. V. , Kolesnikov V. E. , Bondarenko O. K. , Khabzhokov E. K. , Tolmakh R. E. , Dashkov A. V. , Petrov D. S. , Savchenko D. A. , Kolesnikov E. N. , Snezhko A. V. 
Published: February 2023

The purpose of the study was to analyze rectal resection outcomes in patients with rectal cancer.Material and Methods. A retrospective analysis of treatment outcomes of 251 patients with stage cT3–4aN0–2M0 rectal cancer, who underwent transperitoneal resections of the rectum with mesorectumectomy from 2015 to 2020, was carried out. The age of the patients ranged from 27 to 90 years. Considering the extent of rectal tumor spread, 143 (56.9 %) patients underwent neoadjuvant prolonged conformal radiation therapy or chemoradiotherapy.Results. The failure of the colorectal anastomosis was observed in 11 (4.4 %) patients, repeated surgery was performed in 8 (72.7 %) patients (Grade C). During the follow-up, disease progression was detected in 58 (23.1 %) patients, tumor recurrence in the rectum occurred in 2 (0.8 %) patients, and distant metastases were found in 56 (22.3 %) patients. Statistical analysis showed that the parameters, such as the age, localization of the tumor in the rectum, tumor grade and T stage did not significantly affect the disease progression. A statistically significant relationship between the disease progression and pN2 stage was revealed. Patients with pN2 stage were 4.1 times more likely to have disease progression. The 75th percentile survival time was51.2 months. Patients with pN2 stage had a 3.6-fold increase in the risk of lethal outcome.Conclusion. The study demonstrated good oncological and surgical outcomes in the treatment of stage II–III rectal cancer with high survival rates. Resection of the rectum in patients with rectal cancer is a safe and predictable surgical procedure accompanied by a low incidence of anastomotic leaks and disease recurrence. The pN2 stage in rectal cancer patients significantly worsened the oncologic outcomes and survival of patients.
Experience in the use of olaparib poly (ADP-ribose) polymerase inhibitors in maintenance therapy of BRCA-associated ovarian cancer
Authors: Zhurman V. N. , Nechushkina V. M. 
Published: February 2023

Aim to study the frequency of BRCA1/2 gene mutations , the efficacy of ovarian cancer therapy depending on the presence of BRCA1/2 mutations as well as the efficacy of olaparib maintenance therapy in BRCAassociated ovarian cancer.Material and Methods. The retrospective analysis included 355 patients with high-grade, stage I–IV serous ovarian cancer. The examination for a mutation in the BRCA1/2 gene was carried out within the framework of the program “Improvement of molecular genetic diagnostics in the Russian Federation in order to increase the effectiveness of antitumor treatment”.Results. Mutations in the BRCA1/2 genes were detected in 98 out of 355 (27.6 %) patients. Mutations of the BRCA1+ gene were detected in 62 out of 230 patients with ovarian cancer of stages IIIC–IV (27.0 %), the BRCA2 gene – in 9 out of 230 (3.9 %). In ovarian cancer of stages III–IV, BRCA gene mutations were absent in 159 of 230 (69.1 %) patients. The median time to progression in stages III–IV of the disease with a mutation in the BRCA1 gene was 22.0 months, in the BRCA2 gene – 27.0 months, in patients without mutations in the BRCA1/2 genes – 17.0 months, median life expectancy – 70.0; 65.0 and 45.0 months, respectively. Patients with serous ovarian carcinoma of high-grade I–IV stages with the presence of mutations in the BRCA1/2 genes were divided into two groups. The first group (6 out of 26 patients, 23.1 %) consisted of patients with stage IIIC–IV high-grade serous ovarian carcinoma, who received olaparib as maintenance therapy after the 1st line of chemotherapy, the second group (20 out of 26 patients, 76.9 %) were patients with stage I–IV high-grade serous ovarian carcinoma, who received olaparib in maintenance mode after 2 or more lines of chemotherapy.Conclusion. The presence of BRCA1/2 gene mutations significantly increased the median life expectancy of patients with stage IIIC–IV serous ovarian cancer, and primary cytoreduction significantly improved both overall survival and survival to progression in this group of patients. Maintenance therapy with olaparib is more appropriate after the 1st line of treatment than after subsequent ones.
Презентация архетипа личности в семантических структурах
Authors: Склейнис Виктор А. 
Published: February 2023

Введение. Статья посвящена решению задач поиска семантических коррелят архетипического пространства. Автор рассматривает архетипические структуры как системы значений, имеющие различные уровни презентации и соотносимые с трехслойной моделью структуры образа мира, предложенной В. П. Серкиным. Новизна исследования заключается в том, что в работе впервые осуществлено эмпирическое исследование сопряженности семантического пространства Ч. Осгуда (оценка, сила, активность) и архетипического пространства К. Пирсон. Методы. В исследовании приняло участие 320 испытуемых в возрасте от 19 до 66 лет. Определение ведущего архетипа личности осуществлялось при помощи метафорических архетипических карт «12 архетипов плюс», предложенных Т. В. Капустиной. Представления испытуемых о себе изучались при помощи личностного семантического дифференциала. Результаты. Сравнение межгрупповых показателей с использованием критерия Краскелла – Уоллеса показало наличие межгрупповых различий по каждому из факторов личностного семантического дифференциала (оценка, сила, активность). Корреляционный анализ с использованием критерия Пирсона показал наличие сопряженности осей архетипического пространства К. Пирсон и семантического пространства Ч. Осгуда. Так, ось «самопознание – принадлежность» демонстрирует сопряженность с факторами «оценка» и «сила», а ось «стабильность – изменения» – с фактором «активность». Кроме того, фактор «оценка» демонстрирует сопряженность со стадиями архетипического путешествия (подготовка, путь, возвращение). Обсуждение результатов. Наличие сопряженности факторов семантического пространства оценки себя и осей архетипического пространства позволяет рассматривать процесс воплощения архетипических структур в знаковых системах как частных случай проецирования структур ядерного слоя образа мира на семантический слой.
Sleep, Dietary Melatonin Supplementation, and COVID-19
Authors: Gasmi Amin , Semenova Yuliya , Noor Sadaf , Benahmed Asma Gasmi , Bjørklund Geir 
Published: February 2023

Background:
During the COVID-19 pandemic, people suffered from major
mental health problems. These include stress, anxiety, and confusion about the existing situation
of home confinement. Melatonin is a popular anti-inflammatory and antioxidant
molecule sold as an over-the-counter dietary supplement.

Objective:
This review discusses the indications for using melatonin in the context of the
COVID-19 pandemic, including treatment.

Methods:
A comprehensive search of publications was conducted in electronic databases
focusing on the administration of melatonin in COVID-19.

Results:
Stress has a huge negative impact on sleep routines and the quality of life of individuals.
Sleep is considered an important modulator of the immune response. Thus, a
lack of sleep can weaken immunity, increasing organism susceptibility to infection. For
instance, shorter sleep durations are associated with a rise in suffering from the common
cold. The administration of melatonin protects against viral and other pathogens and
speeds clinical recovery.

Conclusion:
In patients admitted to intensive care units, melatonin decreases the risks of
severe complications, such as thrombosis and sepsis, and mortality rates. In addition, it is
efficacious in lowering vessel permeability, depression, and sedation, and improving the
quality of sleep, which could also help COVID-19 patients achieve better clinical outcomes.
Description and In silico ADME Studies of US-FDA Approved Drugs or
Drugs under Clinical Trial which Violate the Lipinski’s Rule of 5
Authors: Lohit Niyatha , Singh Ankit Kumar , Kumar Adarsh , Singh Harshwardhan , Yadav Jagat Pal , Singh Kuldeep , Kumar Pradeep 
Published: February 2023

Background & Objective:
Christopher A. Lipinski, in 1997, formulated Lipinski’s rule of five
for drug-likeness prediction of potent molecules. It states that molecular weight (less than 500 Daltons),
octanol/water partition coefficient (not exceeding more than 5), hydrogen bond acceptor (no more than
10), and hydrogen bond donor (no more than 5) are important for good oral bioavailability. Many drugs
among various important classes such as antibiotics, anti-cancer, HIV and HCV protease inhibitors, immunosuppressants,
cardiovascular, antifungal, and other miscellaneous classes are approved by FDA or
other drug regulatory authorities as clinical use lie beyond the rule of five. In this review, beyond the rule
of 5 drugs belonging to these classes (which are either currently approved or under clinical study) are
explored and their ADME properties are analyzed.

Methods:
Data of 73 beyond the rule of 5 drugs, belonging to various classes, were collected and their
ADME properties were calculated using the Qikprop prediction program of maestro 12.9 module of
Schrodinger software.

Result:
Out of 73 drugs, 4 had at least 1 Rule of 5 (Ro5) violation, 16 had at least 2, 31 had at least 3 out
of which 22 drugs had 4, Ro5 violations.

Conclusion:
Drugs not obeying the rule of five may also serve as good clinical candidates and potential
candidates should not be discarded only on the basis of this rule.
Colorimetric Determination of Glucose based on BiVO4 Coupled with
Gold Nanoparticles as a Photoactivated Mimic Enzyme of Oxidase
Authors: Miao Lili , Sun Jing , Cai Hemeiling , Ma Zhichang , Di Junwei 
Published: February 2023

Background:
The spectrophotometric detection of glucose usually requires the use of glucose
oxidase (GOD) and horseradish peroxidase (HRP). These natural enzymes have specificity and can react
with substrates efficiently and quickly, but their performance is easily influenced by external factors, such
as humidity, temperature, and solution pH. In this study, no enzyme method was developed for the detection
of glucose.

Objective:
In this work, gold nanoparticles (AuNPs) and BiVO4 were calcined onto the glass surface,
offering excellent glucose oxidase-like activity under light irradiation. Coupled with silver nanoparticles
(AgNPs), it can be applied to the colorimetric detection of glucose without the use of any natural enzyme.

Methods:
The heterostructure of AuNPs and BiVO4 onto glass substrate (G/AuNPs/BiVO4) was synthesized
by deposition and calcination at 500°C. It exhibited oxidase-like activity towards glucose oxidation
in the presence of oxygen (O2) under light irradiation and then generated gluconic acid and hydrogen
peroxide (H2O2). The production of H2O2 could etch AgNPs, resulting in a clear color change of the solution.

Results:
A decrease in the absorbance showed a good linear relationship with glucose concentration in the
range of 20-400 μM, with a detection limit of 5 μM.

Conclusion:
An enzyme-free method is proposed for the colorimetric detection of glucose. The photoactivated
enzyme mimic of G/AuNPs/BiVO4 exhibited good recyclability with water rinsing. This is promising
for wide applications in various fields.
LPLSG: Prediction of lncRNA-protein Interaction Based on Local
Network Structure
Authors: Wang Wei , Wang Yongqing , Sun Bin , Liang Shihao , Liu Dong , Zhang Hongjun , Wang Xianfang 
Published: February 2023

Background:
The interaction between RNA and protein plays an important role in life activities. Long ncRNAs (lncRNAs) are large non-coding RNAs, and have received extensive attention in recent years. Because the interaction between RNA and protein is tissue-specific and condition-specific, it is time-consuming and expensive to predict the interaction between lncRNA and protein based on biological wet experiments.

Objective:
The contribution of this paper is to propose a method for prediction based on the local structural similarity of lncRNA-protein interaction (LPI) network.

Methods:
The method computes the local structure similarity of network space, and maps it to LPI space, and uses an innovative algorithm that combined Resource Allocation and improved Collaborative Filtering algorithm to calculate the potential LPI.

Conclusion:
AUPR and AUC are significantly better than the five popular baseline methods. In addition, the case study shows that some results of LPLSG prediction on the actual data set have been verified by NPInterV4.0 database and some literatures.
Advanced Multivariable Statistical Analysis Interactive Tool for Handling
Missing Data and Confounding Covariates for Label-free LC-MS Proteomics
Experiments
Authors: Rai Shesh N. , Srivastava Sudhir , Merchant Michael L. , McClain Craig J. , Rai Anil , Chaturvedi Krishna K. , Angadi Ulavappa B. , Mishra Dwijesh C. 
Published: February 2023

Background:
Careful consideration is required for detecting significant features (proteins or
peptides) in LC-MS proteomics studies using multivariable regression analyses. In proteomics data,
missing values can arise due to random errors, bad samples, features below the detection limit in specific
samples, etc. Further, expression data are always prone to heterogeneity due to technical/biological
reasons. Missing values and heterogeneity in proteomics studies can confound important findings.
Moreover, there is additional information in these studies, such as pre-clinical and clinical information
(e.g., sex, exposure, etc.), which can be used to supplement the inference.

Methods:
We introduce a user-friendly web application SATP (Statistical Analysis interactive Tool for
label-free LC-MS Proteomics experiments) for differential expression analysis of proteomics data that is
scalable to large clinical proteomic studies. Appropriate normalization and imputation methods have
been provided. Apart from these, several statistical tests such as t-test, moderated t-test, linear fixed effect
model, and linear mixed model with adjustment of effect of extra covariates have also been provided
for users' benefit.

Results:
Our intuitive tool has several advantages over the existing ones, including an extension to multiple
factor comparisons after adjusting for covariates.

Conclusion:
This is a comprehensive tool for analysis of complex experiments with multiple covariates,
whereas most of the existing tools were developed for comparing simple experiments mostly with two
groups without covariates.

Availability:
The tool can be accessed freely by the users from https://ulbbf.shinyapps.io/satp/.
Potential of Black Seeds (Nigella sativa) in the Management of Long
COVID or Post-acute Sequelae of COVID-19 (PASC) and Persistent
COVID-19 Symptoms – An Insight
Authors: Pakkir Maideen Naina Mohamed , Hassan Jumale Abdurazak , Ramadan Barakat Ibrahim , Khalifa Albasti Ayesha 
Published: February 2023

Background:
Some individuals may experience symptoms persisting for many months after
the recovery from COVID-19 and patients with Long COVID are managed mainly with symptomatic
treatment and supportive care.

Objective:
This review article focuses on the beneficial effects of black seeds (Nigella Sativa) in the
management of long COVID and persistent COVID symptoms.

Methods:
The literature was searched in databases such as LitCOVID, Web of Science, Google Scholar,
bioRxiv, medRxiv, Science Direct, EBSCO, Scopus, Embase, and reference lists to identify studies,
which evaluated various effects of black seeds (N. sativa) related to signs and symptoms of Long
COVID.

Results:
Black seeds (N. sativa) have shown potential anti-COVID, antiviral, anti-inflammatory, antioxidant,
immunomodulatory, antihypertensive, anti-obesity, antidiabetic, antihyperlipidemic, and antiasthmatic
properties in various clinical, animal, in-vitro, in-vivo, and in-silico studies, which would
help the patients recovered from COVID to mitigate Long COVID complications.

Conclusion:
Patients experiencing Long COVID may use black seeds (N. sativa) as adjunctive therapy
in combination with symptomatic treatment and supportive care to prevent further deterioration and
hospitalization. The safety and efficacy of N. sativa in patients with Long-COVID would further be
established by future randomized controlled clinical trials.
Roughness and Microhardness of Demineralized Enamel Treated with Resinous Infiltrants and Subjected to an Acid Challenge: An in vitro Study
Authors: de Cerqueira Gabriela Alves , Damasceno Janaína Emanuela , Pedreira Priscila Regis , Souza Ana Ferreira , Aguiar Flávio Henrique Baggio , Marchi Giselle Maria 
Published: February 2023

Background:
Resinous infiltrating has proven effective in arresting incipient caries lesions.

Objective:
This study aimed to assess the penetration depth of an experimental resin-infiltrant (75% - TEGDMA, 25% - Bis-EMA, 1% - EDAB, 0.5% camphorquinone), compare it with commercial infiltrant Icon®, and analyze the surface-roughness and microhardness of the resin-materials infiltrated into tooth specimens, before and after pH cycling.

Methods:
To assess penetration depth, sound third molar specimens were submitted to ten de-remineralization cycles for incipient carious lesion induction and were then randomly divided into 2 groups (n=3): (I) Experimental Infiltrant (EI) and (II) Commercial Infiltrant Icon (CI). After resin infiltration into specimens, qualitative Confocal Fluorescence Microscopy images were captured. For roughness and microhardness assessment, new specimens were demineralized, then randomly divided into two groups (n=20): (I) Experimental Infiltrant (EI) and (II) Commercial Infiltrant Icon (CI) and submitted to roughness and microhardness readouts at the following time-intervals: (T1) sound tooth, (T2) white-spot caries lesion, (T3) resin material that infiltrated, and (T4) resin material that infiltrated and was exposed to pH-cycling. In statistical analyses, generalized linear models of repeated measures in time were applied, with a significance level of 5%.

Results:
The experimental infiltrant penetrated the carious lesion and exhibited lower roughness values after its application, even after pH cycling, similar to the CI. The microhardness value of the EI group was significantly lower in the last three-time intervals evaluated compared to CI.

Conclusion:
Experimental resin infiltrant was efficient in penetrating white spot lesions and reducing surface roughness; however, it did not increase surface microhardness.
Comparative Evaluation of Microleakage of Two Variables of Glass-Ionomer Cement: An In vitro Study
Authors: Saida Ziada , Chammack Haifa , Belkhir Chems , Bagga Sana , Sahtout Saida Souad 
Published: February 2023

Introduction:
The emergence of nanotechnology, which has become an important research area in dentistry, has made it possible to obtain nano-structured materials with improved properties compared to their basic form. In this work, we have performed an experimental study on natural teeth to evaluate the microleakage of a Ketac™ Universal nano-filled GIG in box cavities and compare it to a Ketac™ Fil Plus (3M ESPE) conventional GIG.

Materials and Methods:
80 Class II cavities were prepared on the mesial and distal surfaces of forty teeth (twenty molars and twenty premolars). The sample was divided randomly into two groups: Group1 with conditioning and Group 2 without conditioning. The mesial cavities were obturated with Ketac™Universal nano-filled GIG and the distal cavities with Ketac™ Fil Plus GIG. The teeth underwent thermocycling, followed by infiltration with methylene blue. The teeth roots were inserted into methacrylate resin blocks and then sectioned with a chainsaw in the center of both restorations. After observation with a stereomicroscope, the extent of methylene blue infiltration in each restoration was recorded separately for the cervical surface (from 0 to 2) and the axial surface (from 0 to 3).The Chi-squared test with SPSS20.2 software was used to investigate the score distribution.

Results:
Results were considered significant if P<0.05. The Chi-square test showed a significant difference between the nano-filled GIG and the condensable GIG. The nano-filled GIG showed less infiltration, and it was found to be more tight than the conventional GIG.

Conclusion:
The results of the current study suggest that the use of nanotechnology is a promising strategy to improve the clinical performance of GIG. However, this study is limited to an experimental in vitro strategy, which cannot reliably reproduce clinical reality.
Knee Pain Examined under Musculoskeletal Ultrasonography: Experience from a Community-based Rheumatology Practice – A Cross-sectional Study
Authors: Siddiq Md Abu Bakar , Rahim Mohammad Abdur 
Published: February 2023

Background:
Diagnostic musculoskeletal ultrasonogram (MSUS) in musculoskeletal pain practice has increased. MSUS helps delineate extra-and intra-articular structures that are not visible on X-ray.

Objective:
Explore knee pain under ultrasonogram in a primary care rheumatology (PCR) facility.

Methods:
This cross-sectional study was performed over six months (January 1 and June 30, 2021) to explore knee pain in a community-based PCR setting. A physician registered in musculoskeletal (RMSK) ultrasonogram examined all patients and documented data in a prefabricated questionnaire. Statistical Package for the Social Sciences (SPSS, 28.0.1.1) was used to analyze data. Quantitative and categorical variables were presented with frequency and percentage. The Mann-Whitney-U test assessed the correlation between categorical variables; p<0.05 was considered statistically significant.

Results:
A total of 118 knees of 92 patients were included. Following are MSUS-depicted structural changes: medial joint line osteophytes (91.3%), medial femoral condyle (MFC), cartilage echogenicity (78.3%), synovial plica (76%), knee effusion (61.9%), synovial membrane thickening (54.3%), increased medial collateral ligament (MCL) thickness (42.4), reduced trochlear and MFC thickness (36.9%), Baker's cyst (35.8%), increased MFC thickness (31.5%), medial meniscal extrusion (MME) (27.2%), synovial hypertrophy (20.6%), increased trochlear cartilage thickness (20.6%), MM tear (18.5%), semitendinosus (SMT) bursitis (6.5%), loose body (6.5%), frond-like synovial mass (5.4%), MCL calcification (4.3%) and MM cyst (4.3%). There was a statistically significant correlation between the following variables: Knee effusion and synovial plica; reduced MFC thickness; MME and reduced MFC thickness and moderate osteophyte.

Conclusion:
High-frequency diagnostic ultrasound can depict knee pathology precisely. MSUS at the primary healthcare facility can minimize patient referral and burden over the tertiary setting and reduce overall expenditure.