bluuebunny/crossref_metadata_2025_split huggingface dataset:
The accuracy of radiomics in diagnosing tumor deposits and perineural invasion in rectal cancer: a systematic review and meta-analysis
Authors: Liu Xuewu , Lin Feng , Li Danni , Lei Nan 
Published: January 2025

BackgroundRadiomics has emerged as a promising approach for diagnosing, treating, and evaluating the prognosis of various diseases in recent years. Some investigators have utilized radiomics to create preoperative diagnostic models for tumor deposits (TDs) and perineural invasion (PNI) in rectal cancer (RC). However, there is currently a lack of comprehensive, evidence-based support for the diagnostic performance of these models. Thus, the accuracy of radiomic models was assessed in diagnosing preoperative RC TDs and PNI in this study.MethodsPubMed, EMBASE, Web of Science, and Cochrane Library were searched for relevant articles from their establishment up to December 11, 2023. The radiomics quality score (RQS) was used to evaluate the risk of bias in the methodological quality and research level of the included studies.ResultsThis meta-analysis included 15 eligible studies, most of which employed logistic regression models (LRMs). For diagnosing TDs, the c-index, sensitivity, and specificity of models based on radiomic features (RFs) alone were 0.85 (95% CI: 0.79 - 0.90), 0.85 (95% CI: 0.75 - 0.91), and 0.82 (95% CI: 0.70 - 0.89); in the validation set, the c-index, sensitivity, and specificity of models based on both RFs and interpretable CFs were 0.87 (95% CI: 0.83 - 0.91), 0.91 (95% CI: 0.72 - 0.99), and 0.65 (95% CI: 0.53 - 0.76), respectively. For diagnosing PNI, the c-index, sensitivity, and specificity of models based on RFs alone were 0.80 (95% CI: 0.74 - 0.86), 0.64 (95% CI: 0.44 - 0.80), and 0.79 (95% CI: 0.68 - 0.87) in the validation set; in the validation set, the c-index, sensitivity, and specificity of models based on both RFs and interpretable CFs were 0.83 (95% CI: 0.77 - 0.89), 0.60 (95% CI: 0.48 - 0.71), and 0.90 (95% CI: 0.84 - 0.94), respectively.ConclusionsDiagnostic models based on both RFs and CFs have proven effective in preoperatively diagnosing TDs and PNI in RC. This non-invasive method shows promise as a new approach.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?RecordID=498660, identifier CRD42024498660.
Peritoneal chemotherapy delivery systems for ovarian cancer treatment: systematic review of animal models
Authors: Simonsen Marcelo , Mendoza López Rossana Verónica , Maistro Simone , Ikeoka Lucas Takeshi , Pereira Glaucia Fernanda de Lima , Lugão Ademar Benévolo , Sadalla José Carlos , Katayama Maria Lúcia Hirata , Folgueira Maria Aparecida Azevedo Koike 
Published: January 2025

IntroductionIntraperitoneal chemotherapy for ovarian cancer treatment has controversial benefits as most methodologies are associated with significant morbidity. We carried out a systematic review to compare tumor response, measured by tumor weight and volume, between intraperitoneal chemotherapy delivered via drug delivery systems (DDSs) and free intraperitoneal chemotherapy in animal models of ovarian cancer. The secondary aim was to assess the toxicity of DDS-delivered chemotherapy, based on changes in animal body weight.MethodsBased on PRISMA and SYRCLE guidelines, we identified 38 studies for review, of which 20, were used in the meta-analysis. We evaluated outcome, through tumor volume and tumor weight and, toxicity, through animal weight. Analysis was based on drugs employed and treatment duration.ResultsMost studies were performed on mice. Ovarian cancer cell lines most commonly used to induce xenografts were SKOV3 (19 studies) and A2780 (6 studies). Intraperitoneal device, also known as drug delivery systems (DDS), consisted in nanoparticles, hydrogels, lipid polymer and others. The most commonly used drugs were paclitaxel and cisplatin. Most studies used as the control treatment the same chemotherapy applied free intraperitoneally and tumor response/animal weight were evaluated weekly. There was a small benefit in overall tumor reduction in animals treated with intraperitoneal chemotherapy applied through the slow release device compared with animals treated with intraperitoneal free chemotherapy, as evaluated through tumor weight - results in standardized mean difference. (-1.06; 95% CI: -1.34, -0.78) and tumor volume (-3.72; 95% CI: -4.47, -2.97), a benefit that was seen in most weekly evaluations and for most chemotherapy drugs, such as carboplatin (tumor weight: -5.60; 95% CI: -7.83, -3.37), paclitaxel (tumor weight: -1.18; 95% CI: -1.52, -0.83), and cisplatin (tumor volume: -2.85; 95% CI: -3.66, -2.04) carboplatin (tumor volume: -12.71; 95% CI: -17.35, -8.07); cisplatin (tumor volume: -7.76; 95% CI: -9.88, -5.65); paclitaxel (tumor volume: -2.85; 95% CI: -3.66, -2.04). Regarding animal weight, there was no weight reduction in animals treated with intraperitoneal chemotherapy applied through the slow-release device compared with animals treated with intraperitoneal free chemotherapy. However, significant heterogeneity was observed in some comparisons.Conclusionslow-release devices are overall safe and effective in animal models of ovarian cancer. It was not possible to evaluate which one is the most promising device to treat ovarian cancer, because many different types were used to apply chemotherapy intraperitoneally.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/, identifier CRD42021224573.
Efficacy and safety of anticoagulants on venous thromboembolism: a systematic review and network meta-analysis of randomized controlled trials
Authors: Fu Weijie , Zhao Maolin , Ding Sheng , Xin Mei , Yang Ke , Jiang Li , Wu Fan , Wu Xiaochen , Wang Jian , Chen Jie , Gao Feng , He Siyi 
Published: January 2025

BackgroundAnticoagulants are the primary means for the treatment and prevention of venous thromboembolism (VTE), but their clinical standardized application still remains controversial. The present study intends to comprehensively compare the efficacy and safety of various anticoagulants in VTE.MethodsMedline, Embase, and Cochrane Library from their inception up to August 2023 were searched to compare the efficacy and safety of various anticoagulants in VTE. We extracted data on study settings, baseline characteristics, interventions, and outcomes, applying the intention-to-treat principle. Two researchers assessed study bias using the Cochrane tool, resolving disagreements through discussion or third-party adjudication. Network meta-analyses were performed based on Bayesian generalized linear models, and a frequentist framework with multivariate random effects was used to fit the model.ResultsIn terms of treatment, 58 trials with 119,417 patients proved eligible, while 125 trials with 225,414 patients were included in terms of prevention. All anticoagulants were found to reduce the recurrence or incidence of VTE compared with Placebo, of which high-level evidence indicated that direct thrombin inhibitors (TIs) and novel oral anticoagulants (NOACs) were the two most effective drugs. For treatment, low molecular weight heparin (LMWH), unfractionated heparin (UFH), and vitamin K antagonists (VKAs) significantly increased the risk of major bleeding in comparison to Placebo. For prevention, only UFH (OR 2.0, 95% CI 1.2–3.3) and NOACs (OR 1.8, 95% CI 1.2–2.6) showed significant increased risks in major bleeding. Additionally, after an exhaustive analysis of NOACs, analysis showed that apixaban (RR 0.5, 95%CI 0.17–1.46) had a superior performance in major bleeding compared to rivaroxaban (RR 3.87, 95%CI 1.48–10.09).ConclusionTIs and NOACs were superior in efficacy with minimal side effects, making them pivotal choices for both prevention and treatment of VTE. Clinical practitioners must carefully weigh drug characteristics, indications, and contraindications to optimize treatment outcomes.Systematic Review Registrationhttps://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=466775.
Photodynamic therapy with a novel photosensitizer inhibits DSS-induced ulcerative colitis in rats via the NF-κB signaling pathway
Authors: Rong Yumei , Zhu Minghui , Wang Nan , Zhang Feiyu , Liu Tianjun 
Published: January 2025

IntroductionUlcerative colitis (UC) is an inflammatory bowel disease characterized by inflammation and ulceration of the digestive tract.MethodsPhotodynamic therapy (PDT) with a novel photosensitizer LD4 was used to treat UC rat models to explore the therapeutic effect and mechanism of LD4-PDT on UC. 16S ribosomal RNA was used to detect the composition of Gut microbiota.ResultsOur findings indicate that LD4-PDT could protect the integrity of the colonic mucosa, alleviate the inflammatory response and promote the healing of colonic mucosa. Mechanism studies demonstrated that LD4-PDT could inhibit the NF-κB signaling pathway, downregulated the expression of the inflammatory factors’ tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and myeloperoxidase (MPO), increased the contents of glutathione (GSH) and superoxide dismutase (SOD) and decreased the content of malondialdehyde (MDA). Additionally, analysis of gut microbiota revealed that LD4-PDT treatment could decrease the abundance of the Proteobacteria phylum in fecal samples, while no significant differences were observed in the Firmicutes, Bacteroidetes, or Actinobacteria phyla among the three groups using 16S rRNA analysis.DiscussionIn summary, our data suggested that LD4-PDT could inhibit DSS-induced UC in rats via the NF-κB signaling pathway, indicating its potential as a novel photosensitizer for the treatment of UC.
Salivary testosterone and cortisol responses to seven weeks of practical blood flow restriction training in collegiate American football players
Authors: Luebbers Paul E. , Kriley Luke M. , Eserhaut Drake A. , Andre Matthew J. , Butler Michael S. , Fry Andrew C. 
Published: January 2025

PurposeThe purpose of this study was to examine the effects of a 7-week supplemental BFR training intervention on both acute and chronic alterations in salivary testosterone (sTes) and cortisol (sCort) in collegiate American football players.Methods58 males were divided into 4 groups: 3 completed an upper- and lower-body split resistance training routine (H, H/S, H/S/R; H = Heavy, S = Supplemental, R = BFR), with H/S/R performing end-of-session practical BFR training, and H/S serving as the volume-matched non-BFR group. The final group (M/S/R) completed modified resistance training programming with the same practical BFR protocol as H/S/R. Athletes were further split into AM and PM training groups based upon their pre-determined training schedules, in cooperation with University strength and conditioning staff. Practical BFR consisted of end-of-session barbell bench press and back squat using 20% 1 repetition maximum (1RM) for 30-20-20-20 repetitions across 4 sets, with 45-seconds rest. Saliva samples were taken pre- and post- the first lower-body training sessions in week 1 and week 7 (i.e., test 1 and test 2) of the program, yielding four total. sTes and sCort were analyzed using 4-way (4 × 2 × 2 × 2) mixed model ANOVA’s.ResultsHormonal variables all exhibited main effects for time-of-day (p &lt; 0.001). A significant group × time interaction effect (F3,50 = 3.246, p &lt; 0.05) indicated increases in sTes post-training cycle for the H/S/R group only. Further, PM post-exercise sCort decreased from test 1 to test 2 (nmol·L−1: 95% CI: PM test 1 post-exercise = 10.7–17.1, PM test 2 post-exercise = 5.0–8.9). For the testosterone-to-cortisol ratio (T/C), AM pre-exercise was lower than PM (p &lt; 0.05), with no change in post-exercise T/C for both AM and PM conditions when collapsed across testing times.DiscussionOverall, these findings suggest an ecologically valid method of BFR implementation is capable of inducing heightened concentrations of sTes in well-resistance trained American football athletes, providing additional insight on possible physiological mechanisms underpinning BFR’s ability to elicit beneficial muscle hypertrophy and maximal strength adaptations when performed during regimented training programs. Additionally, notable rises in T/C, and a null sCort response post-exercise were observed post-program for all groups, possibly indicative of positive physiological adaptation.
Participants’ satisfaction with social security is closely associated with their acceptance of vulnerable groups: a nationwide cross-sectional study in China
Authors: Guo Chaowei , Wu Yifan , Ge Lina , Qi Li , Ma Yi , Zang Shuang 
Published: January 2025

IntroductionSocial security, as a core component of the national welfare system, has consistently played a crucial role in ensuring the basic livelihood of citizens and promoting social equity and justice. Against this backdrop, this study explores the association between social security satisfaction and acceptance of vulnerable groups.MethodsThis study involved 9923 participants. Generalized linear regression and smooth curve fitting were used to assess the association between social security satisfaction and acceptance of vulnerable groups. Threshold effect was examined by piecewise regression. We conducted subgroup analyses and assessed the potential interaction effect.ResultsA non‑linear association was detected between social security satisfaction and inclusion of vulnerable groups with an inflection point of 45.00. When social security satisfaction was &lt; 45.00, inclusion of vulnerable groups increased with increasing social security satisfaction score up to inflection point. The association between social security satisfaction and inclusion of vulnerable groups differed across gender, education level, and spouse subgroups.DiscussionThe study reveals the importance of social security satisfaction on their acceptance of vulnerable groups. It has a significant meaning in enhancing individuals’ acceptance of vulnerable groups level.
Effectiveness of the mobile Stress Autism Mate Junior application in reducing stress and improving quality of life in adolescents with autism: a pilot study
Authors: van Asselt Alvin , Hoeberichts Kirsten , Demirel Sevda , Scheeren Anke , Roke Yvette 
Published: January 2025

ObjectiveStudies indicate that stress levels of autistic adolescents may be particularly high. Therefore, support is needed to help them deal with their stressors. Stress Autism Mate (SAM) Junior, a mobile self-help tool, was designed in co-creation with adolescents with autism to help reduce daily stress levels. The app is based on the SAM app, which was previously shown to be effective in reducing stress in autistic adults. This study aimed to evaluate the effectiveness of the SAM Junior app in reducing perceived stress and maladaptive coping styles, and increasing adaptive coping styles and quality of life in adolescents with autism.MethodsA total of 24 Dutch adolescents with autism participated in this Single Case Experimental Design study. Sixteen of them (9 girls and 7 boys; Mage = 15.0 years, SD = 1.9) completed all research phases. Data were collected at four time points separated by four weeks: Control, pre-test, post-test and follow-up. Linear mixed-effects models were used to analyze the data.ResultsAt post-test, use of the SAM Junior app had no significant effects on participants’ perceived stress (B = 0.31; 95% CI [-1.59, 2.22], p = .73), adaptive coping (B = -1.38; 95% CI [-5.69, 2.94], p = .51), maladaptive coping (B = -0.63; 95% CI [-4.56, 3.30], p = .74) and quality of life (B = -4.13; 95% CI [-12.19, 3.94], p = .29). These non-significant effects persisted at follow-up.DiscussionCurrent preliminary results do not show effectiveness of the SAM Junior app to support adolescents with autism. Using the app as intended, without professional supervision, may have been too complex for this population. Further research is needed to determine the potential effects of the SAM Junior app with more certainty.
The role of PCBP1 in carbon ion-induced ferroptosis and inhibition of lung adenocarcinoma proliferation
Authors: Kang Zhenchao , Fu Zihan , Tian Xuejiao , Geng Yichao , Zhang Qiuning , Liu Yanli , Wang Xinhua , Luo Hongtao , Yang Zhen 
Published: January 2025

ObjectiveTo investigate the role of PCBP1 in the inhibition of lung adenocarcinoma proliferation by carbon irradiation.MethodsA549 cells were irradiated with different doses of carbon ions to observe clonal survival and detect changes in cell proliferation. Whole transcriptome sequencing and the Illumina platform were used to analyze the differentially expressed genes in A549 cells after carbon ion irradiation. The relationship between the expression levels of PCBP1, ACSL4, and ALOX15 and survival was analyzed by combining data from the UCSC database and the Kaplan–Meier Plotter public platform. Additionally, the knockdown of the poly (rC)-binding protein 1 (PCBP1) gene using siRNA techniques was employed to further investigate the relationship between the expression levels of PCBP1 and ALOX15. To investigate the relationship between ALOX15 expression and survival, we assessed changes in key indicators of ferroptosis (mitochondrial morphology, ROS, MDA, and divalent iron) in A549 cells after knocking down the PCBP1 gene using siRNA technology. Additionally, the expressions of PCBP1, ACSL4, and ALOX15 in different groups were further analyzed through RT-PCR and Western blot techniques. The differential expression of PCBP1, ACSL4, and ALOX15 in NSCLC tissues was found to correlate with clinical prognosis for survival.ResultsCarbon ions significantly inhibited the proliferation of A549 cells, and 5.16 Gy carbon ions significantly induced the expression of differentially expressed genes in these cells. Additionally, carbon ions inhibited the expression of PCBP1, which led to alterations in mitochondrial morphology in lung adenocarcinoma cells. This was associated with a significant increase in the levels of ROS, MDA, and Fe2+. Furthermore, low expression of PCBP1 promoted ferroptosis by increasing the expression of ACSL4 and ALOX15.ConclusionCarbon ions decreased the expression of PCBP1 in A549 cells, and low expression of PCBP1 inhibited tumor proliferation by promoting ferroptosis.
Community acceptance of services and effectiveness of health camps in high-risk areas of Karachi, Sindh, Pakistan, 2021
Authors: Abbasi Fayaz Hussain , Mehraj Jaishri , Khowaja Azeem , Sodhar Irshad Ali , Chandio Shoukat Ali , Rasool Shumaila , Zardari Asif Ali , Hussain Imtiaz , Bosan Altaf , Stuckey Erin M. , Shaikh Ahmed Ali 
Published: January 2025

IntroductionHealth camps are organized to provide basic health services in underprivileged communities. This study was conducted to determine community acceptance and effectiveness of health camps in the high-risk areas for the polio program in Karachi, Pakistan.MethodsThis cross-sectional survey was conducted at the health campsites in high-risk union councils (HRUCs) of four districts of Karachi, Sindh. The survey was carried out in three rounds after a polio vaccination campaign in June, August, and October 2021. In June and August, health camps were organized in eight HRUCs; in October, the scope was extended to 33 union councils. All health camps provided basic health services, maternal and child health services, and routine immunization.ResultsIn June 877, August 367, and October 383 respondents participated in the survey. The main services availed include consultation with a doctor (64% in June, 79% in August, 78% in October), followed by childhood vaccination (58% in June, 55% in August, 69% in October), and nutrition support (34% in June, 17% in August, 17% in October). Children’s immunization increased from 80% in June to 86% in August and 96% in October health camp rounds. Among parents who do not allow oral polio vaccine from polio teams at their doorstep, also vaccinated children at the health camps 48 (81%) in June, eight (80%) in August, and 13 (87%) in October.ConclusionHealth camps played a crucial role in building the reputation of the polio program among underserved communities in Karachi’s high-risk areas. Alongside routine immunization vaccination services, the provision of public health services such as permanent healthcare facilities, access to safe drinking water, proper waste disposal, and mother and child healthcare services, are crucial steps toward improving immunization and overall health outcomes and strengthening community trust.
The impact of work–family conflict on early childhood teachers’ occupational well-being: the chain mediating role of psychological empowerment and job crafting
Authors: Wang Liqun , Qiao Tianqi , Wang Xinxin , Wang Chen , Ye Pingzhi 
Published: January 2025

PurposeThe occupational well-being of early childhood teachers, as a crucial measure of the stability of the early childhood workforce, is increasingly becoming a core topic of interest within the education system. Work-related stressors, particularly work–family conflict, have drawn significant attention for their impact on the occupational well-being of early childhood teachers, becoming a prominent issue in the education field. However, current research rarely explores the relationship between these factors and the underlying mechanisms involved. Therefore, this study aims to investigate the relationship between work–family conflict and the occupational well-being of early childhood teachers and the mediating role of psychological empowerment and job crafting.MethodsThis study conducted a survey involving 1,200 early childhood teachers from Guangdong Province, China, using personal information forms and four scales. The collected data were processed and analyzed using SPSS 27.0.ResultsWork–family conflict showed a significant negative correlation with early childhood teacher’s occupational well-being (β = −0.268, p &lt; 0.001). Psychological empowerment (indirect effect size = −0.049) and job crafting (indirect effect size = −0.019) partially mediated the relationship between work–family conflict and occupational well-being. Furthermore, psychological empowerment and job crafting played a chain mediating role between work–family conflict and occupational well-being (indirect effect size = −0.036).ConclusionThis study reveals the underlying mechanisms by which work–family conflict affects early childhood teachers’ occupational well-being. The findings demonstrate that work–family conflict has a direct and negative impact on the occupational well-being of early childhood teachers. Psychological empowerment and job crafting both partially mediate the relationship between work–family conflict and occupational well-being among early childhood teachers, and they also function in a serial mediating role within this association. The study provides crucial evidence supporting the significant impact of work-related stressors on early childhood teachers’ occupational well-being, serving as a reference for policymakers and educators in developing interventions targeting occupational well-being.