bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of regional anesthesia with oncological outcomes in patients receiving surgery for bladder cancer: A meta-analysis of observational studies
Authors: Illias Amina M. , Yu Kai-Jie , Wu Shao-Chun , Cata Juan P. , Tsai Yung-fong , Hung Kuo-Chuan 
Published: February 2023

BackgroundThis meta-analysis was conducted to compare cancer recurrence and survival rates in patients with bladder cancer receiving surgery under general anesthesia alone (i.e., GA group) or regional anesthesia (RA) with or without GA (i.e., RA ± GA group).MethodsLiterature search on Cochrane library, EMBASE, Google scholar, and Medline databases was performed to identify all relevant studies from inception to April 30, 2022. The primary outcome was cancer recurrence rate, while the secondary outcomes included overall survival rate and cancer-specific survival rate. Subgroup analyses were performed based on study design [(Propensity-score matching (PSM) vs. no-PSM)] and type of surgery [transurethral resection of bladder tumor (TURBT) vs. radical cystectomy].ResultsTen retrospective studies with a total of 13,218 patients (RA ± GA group n=4,884, GA group n=8,334) were included. There was no difference between RA ± GA group and GA group in age, the proportion of males, severe comorbidities, the proportion of patients receiving chemotherapy, and the pathological findings (all p &gt;0.05). Patients in the RA ± GA group had significantly lower rate of bladder cancer recurrence [odds ratio (OR): 0.74, 95%CI: 0.61 to 0.9, p=0.003, I2 = 24%, six studies] compared to those in the GA group. Subgroup analyses based on study design revealed a consistent finding, while the beneficial effect of RA ± GA on reducing cancer recurrence was only significant in patients receiving TURBT (p=0.02), but not in those undergoing radical cystectomy (p=0.16). There were no significant differences in overall survival rate and cancer-specific survival rate between RA ± GA and GA groups.ConclusionsFor patients receiving surgery for bladder cancer, the application of regional anesthesia with or without general anesthesia is associated with significant decrease in cancer recurrence, especially in patients undergoing TURBT for non-muscle invasive bladder cancer. Because of the limited number of studies included and potential confounding factors, our results should be interpreted carefully.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, identifier CRD42022328134.
Significance of searching for ganglia in the terminal rectum/fistula of complex anorectal malformations: Related to defecation function
Authors: Feng Wei , Mu Huaqi , Chen Minmin , Zhu Jin , Xiang Chenzhu , Fan Linxiao , Hou Jinping , Die Xiaohong , Wang Yi 
Published: February 2023

BackgroundThe need to search for ganglia in the terminal rectum/fistula of complex anorectal malformations (ARMs) remains controversial. This study aims to evaluate the relationship between ganglia absence in the terminal rectum/fistula and defecation function after anoplasty.MethodsA retrospective review of patients who received anoplasty for treating male imperforate anus with rectobulbar (RB)/rectoprostatic (RP) fistulas at a tertiary pediatric hospital was conducted with registered demographic data, imaging study results, and information on the terminal rectum/fistula specimen (excision extension and pathological findings). According to the pathological findings, patients were divided into Groups 1 (ganglia absence) and 2 (ganglia presence). Furthermore, the postoperative defecation function was evaluated using various rating scale questionnaires. Statistical analysis was performed using SPSS 22.0.ResultsOf the 62 patients, 18 (29.0%) showed ganglia absence in the terminal rectum/fistula. By analyzing the imaging data, spinal anomalies and spinal cord anomalies were found in 30.6% (19/62) and 56.5% (35/62) of patients, respectively. Baseline information was comparable between Groups 1 and 2 (P &gt; 0.05). For defecation function, there were no significant differences in Kelly scores between the two groups (4.0 ± 0.8 vs. 4.4 ± 1.1, P = 0.177), while Krickenbeck (3.7 ± 1.8 vs. 5.2 ± 1.4) and Rintala (13.7 ± 3.6 vs. 16.0 ± 2.7) scores in Group 1 were significantly lower than those in Group 2 (both P &lt; 0.05). The overall incidence of constipation was 50% (31/62), being higher for Group 1 than Group 2 (77.5% vs. 38.6%, P = 0.002). The area under the curve of ganglia absence for predicting constipation was 0.696, with 77.8% sensitivity and 61.4% specificity.ConclusionGanglia absence in the terminal rectum/fistula of male imperforate anus with RB/RP fistulas is associated with constipation after anoplasty, but it has limited predictive value for postoperative constipation. It is necessary to search for ganglia in the terminal rectum/fistula, both intraoperatively and postoperatively.
GHRH-GH-IGF1 axis in pediatric Down syndrome: A systematic review and mini meta-analysis
Authors: Shaki David , Hershkovitz Eli , Tamam Shai , Bollotin Arkadi , David Odeya , Yalovitsky Guy , Loewenthal Neta , Carmon Lior , Walker Dganit , Haim Alon 
Published: February 2023

ObjectiveTo analyze and determine the quality of functioning in different components of GHRH-GH-IGF1 axis in children with Down syndrome (DS).DesignSystematic review and mini meta-analysis of the literature.MethodsA search was performed in PubMed, Embase, Scopus, and PsycINFO through August 2022. Eligible studies included pediatric patients with DS who had undergone any laboratory evaluation of the GHRH-GH-IGF1 axis. Two reviewers independently screened articles for eligibility. Results of each type of test were weighed together in patients both with and without DS and were pooled using a random effects meta-analysis.ResultsIn total, 20 studies assessed the GHRH-GH-IGF1 axis function. A defect in three major components of GHRH-GH-IGF1 axis was found in a significant proportion of pediatric DS patients.ConclusionsA significant portion of short-stature pathogenesis in children with DS is associated with impaired GHRH-GH-IGF1 axis function.
Psychological impact of COVID-19: A cross-lagged network analysis from the English Longitudinal Study of Aging COVID-19 database
Authors: Ramos-Vera Cristian , García O'Diana Angel , Basauri Miguel Delgado , Calle Dennis Huánuco , Saintila Jacksaint 
Published: February 2023

BackgroundThe COVID-19 pandemic and its subsequent health restrictions had an unprecedented impact on mental health, contributing to the emergence and reinforcement of various psychopathological symptoms. This complex interaction needs to be examined especially in a vulnerable population such as older adults.ObjectiveIn the present study we analyzed network structures of depressive symptoms, anxiety, and loneliness from the English Longitudinal Study of Aging COVID-19 Substudy over two waves (Months of June–July and November–December 2020).MethodsFor this purpose, we use measures of centrality (expected and bridge-expected influence) in addition to the Clique Percolation method to identify overlapping symptoms between communities. We also use directed networks to identify direct effects between variables at the longitudinal level.ResultsUK adults aged &gt;50 participated, Wave 1: 5,797 (54% female) and Wave 2: 6,512 (56% female). Cross-sectional findings indicated that difficulty relaxing, anxious mood, and excessive worry symptoms were the strongest and similar measures of centrality (Expected Influence) in both waves, while depressive mood was the one that allowed interconnection between all networks (bridge expected influence). On the other hand, sadness and difficulty sleeping were symptoms that reflected the highest comorbidity among all variables during the first and second waves, respectively. Finally, at the longitudinal level, we found a clear predictive effect in the direction of the nervousness symptom, which was reinforced by depressive symptoms (difficulties in enjoying life) and loneliness (feeling of being excluded or cut off from others).ConclusionOur findings suggest that depressive, anxious, and loneliness symptoms were dynamically reinforced as a function of pandemic context in older adults in the UK.
Cinquante ans après la découverte : état des connaissances et apport des fouilles récentes sur le site campaniforme de la République à Talmont- Saint-Hilaire (Vendée)
Authors: Rousseau Lolita , Gandois Henri , Favrel Quentin , Cuenca solana David , Dupont Catherine , Garnier Nicolas , Guéret Colas , Laforge Marine , Poissonnier Bertrand , Vigneau T. 
Published: February 2023

Le site de la République est localisé en bordure de microfalaise à Talmont-Saint-Hilaire en Vendée (France). Il s’intègre au sein d’un vaste réseau d’occupations campaniformes observable tout le long du littoral vendéen, où près d’une quinzaine de sites sont attestés. Il a été découvert en 1968 par R. Joussaume suite à des prospections de surface et a fait l’objet de plusieurs opérations archéologiques de sauvetage entre 1988 et 2015 (B. Poissonnier en 1988, J.-M. Gilbert en 1990, H. Gandois et L. Rousseau en 2014 et 2015). En effet, il fait face à une érosion marine constante faisant apparaître très régulièrement des vestiges en surface ou en coupe de falaise. Cet article permet de faire le point sur cinquante années de découvertes effectuées sur cette vaste occupation attribuée à la culture campaniforme. Cette dernière se caractérise par un important lot de céramiques (l’un des plus conséquents pour le nord-ouest de la France : vases décorés à la coquille et au peigne et vases à cordons) et de pièces lithiques (débitage par percussion posée sur enclume, outils macrolithiques liés à des activités domestiques et de taille et amas de débitage), mais aussi par des indices d’une métallurgie cuprifère précoce. Cette dernière a été reconnue dès les interventions anciennes par la présence de scories et de deux structures possiblement associées (même si l’hypothèse de structures à sel peut être aussi suggérée). Les dernières fouilles ont permis de montrer que cette activité a été menée in situ par le biais d’une technique
inédite pour la façade atlantique, à savoir la réduction du minerai dans un vase-four. Enfin, les fouilles récentes ont été l’occasion d’apporter un nouveau regard sur ce site majeur, d’étudier l’intégralité du mobilier archéologique dont une grande partie était restée jusqu’alors inédite, ainsi que de réaliser de nouvelles analyses scientifiques (tracéologie, datation 14C, analyses des éléments cuivreux et des résidus de cuisson dans les céramiques).
Single-walled carbon nanotube growth from Ni catalyst particles under conventional growth conditions by alcohol catalytic chemical vapor deposition: in situ X-ray absorption fine structure study
Authors: Karasawa Shusaku , Saida Takahiro , Sharma Kamal Prasad , Naritsuka Shigeya , Maruyama Takahiro 
Published: February 2023

Abstract
In situ X-ray absorption fine structure (XAFS) analysis was performed on Ni catalysts during the growth of single-walled carbon nanotubes (SWCNTs) by alcohol catalytic chemical vapor deposition (ACCVD). Ni catalysts were gradually reduced during the heating process and became metallic at the growth temperature (800 °C). With the addition of ethanol during SWCNT growth, Ni catalysts were slightly carbonized. Such behavior was similar to that observed for Ir catalysts in our previous study, although the Ni catalysts had a carbon composition of ∼5%. The results of this study demonstrated the growth of SWCNTs from almost metallic catalysts under the conventional growth conditions of ACCVD using Ni catalysts. Our result obtained by in situ XAFS analysis was consistent with the result of atomistic computer simulations.
STUDY ON THE EFFECTIVENESS OF ADDING SOME PLANT EXTRACTS WITH BHT ON MEAT QUALITY OF LAMB PATTIES DURING CHILLING STORAGE
Authors: Ibrahim, A. Baker  
Published: February 2023

This experiment was aimed to evaluate and compare the effects of adding natural extracts (clove, Mentha and thyme) with synthetic BHT on some physiochemical, microbial, and sensory characteristics of lamb patties stored at 4 Cº for 12 days. Results indicated that there’s a steady rise (P<0.01) in oxidative rancidity, microbial and pH with the increasing time of storage. Also, a significant (P<0.01) reduction in TBA, microbial and pH was observed in patties treated with clove, thyme, mentha and BHT as compared with untreated samples. It was found that adding natural extracts is more effective in inhibiting microbial count than did BHT. The highest score of overall acceptability was noticed in patties blended with thyme and mentha, and the lowest was recorded in control samples
Optical embodiments of Rabi splitting based in photonic integrated waveguide-coupled resonators
Authors: Moss David 
Published: February 2023

<p>Realizing optical analogues of quantum phenomena in atomic, molecular, or condensed matter physics has underpinned a range of photonic technologies. Rabi splitting is a quantum phenomenon induced by a strong interaction between two quantum states, and its optical analogues are of fundamental importance for the manipulation of light-matter interactions with wide applications in optoelectronics and nonlinear optics. Here, we propose and theoretically investigate purely optical analogues of Rabi splitting in integrated waveguide-coupled resonators formed by two Sagnac interferometers. By tailoring the coherent mode interference, the spectral response of the devices is engineered to achieve optical analogues of Rabi splitting with anti-crossing behavior in the resonances. Transitions between the Lorentzian, Fano, and Rabi splitting spectral lineshapes are achieved by simply changing the phase shift along the waveguide connecting the two Sagnac interferometers, revealing interesting physical insights about the evolution of different optical analogues of quantum phenomena. The impact of the device structural parameters is also analyzed to facilitate device design and optimization. These results suggest a new way for realizing optical analogues of Rabi splitting based on integrated waveguide-coupled resonators, paving the way for many potential applications that manipulate light-matter interactions in the strong coupling regime. </p>
Edge Computing in the Internet of Things: A Survey
Authors: Elmassik Ziad 
Published: February 2023

<p>Over the past few decades, the conventional means for data computation were the exploitation of centralized cloud computers. However, with the proliferation of mobile devices and latency-sensitive applications, the conventional approach has grown inadequate. Instead, the edge computing paradigm is created to remedy the shortcomings of the cloud-based systems by transitioning computation of data from centralized data centers to the devices at the edge of the network. This presents a utopia of benefits such as low latency responses, efficient power consumption and ease of mobility for computing services. However, the implementation of edge computing is non-trivial and brings forth various challenges that must be addressed in order for edge computing to be fully developed. The goal of this paper is to better understand these challenges in hopes of neutralizing them. </p>
Data Protection in Healthcare-Integrated Biobanking
Authors: Duhm-Harbeck Petra , Habermann Jens K. 
Published: February 2023

ABSTRACTIntroductionDevelopment of personalized medicine depends on research using clinical biospecimens and data. This interface between clinical care and translational research is increasingly served by hospital-integrated biobanks; yet their implementation is hampered by complex data regulations.MethodsA generic data protection concept with a decision and application matrix was developed addressing five criteria: (1) organizational integration into university medicine, (2) biobank governance, (3) ethical and legal aspects, (4) specifications of the BSI (Bundesamt für Sicherheit in der Informationstechnik [Federal Office for Information Security]), and (5) FAIR (findable, accessible, interoperable, and reusable) principles for research data. Applicability was tested for the highest complexity level at Campus Lübeck.ResultsThe data protection concept was approved by the local ethics committee as well as local and national data protection authorities. The concept allows an automated research-guided patient recruitment and data protection-compliant information technology (IT) in connection to national and international research networks. It ensures university and hospital conformity with the EU Data Protection Regulation. Consent behavior of 277,766 patients over five years proved routine practicability (error rate 0.0013%; withdrawals 0.09%). Clinical staff obtained higher consent rates (85.6%) compared with consent rates for use of data only at central patient admission (56.1%); even though consents in central patient admission increased constantly during observation time.ConclusionThe generic data protection concept can legitimately enable personalized medicine through biobanking in the clinical context.
Peningkatan Motivasi Dan Hasil Belajar Pada Materi Satuan Waktu Melalui Model Pembelajaran Discovery Learning Pada Siswa Kelas III SD Negeri Cinyawang 02 Semester 2 Tahun Pelajaran 2020/2021
Authors: Saputri Anugrah Ningrum , Krisandi Apri Damai Sagita , Sarwi Marciana 
Published: February 2023

Tujuan dari penelitian ini untuk meningkatkan motivasi dan hasil belajar matematika pada materi satuan waktu dengan menggunakan metode pembelajaran Discovery Learning untuk siswa kelas III SD Negeri Cinyawang 02 Tahun Pelajaran 2020/2021. Metode penelitian ini adalah penelitian tindakan kelas dilakukan dengan dua siklus tindakan yang masing-masing siklus meliputi (1) perencanaan, (2) pelaksanaan, (3) observasi, dan (4) refleksi. Subjek penelitian ini adalah siswa kelas III tahun pelajaran 2020/2021 berjumlah 12 siswa, perempuan 8 siswa dan laki-laki 4 siswa. Metode pengumpulan data menggunakan lembar observasi, pedoman wawancara, tes dan dokumentasi. Berdasarkan hasil penelitian tindakan kelas ini dapat disimpulkan bahwa pembelajaran matematika materi satuan waktu dengan menggunakan metode pembelajaran Discovery Learning dapat meningkatkan motivasi dan hasil belajar siswa. Hal ini tampak pada peningkatan skor motivasi belajar dari kondisi awal 8,3% (tinggi), menjadi 25,7% (tinggi) pada siklus I, kemudian siklus II meningkat menjadi 70,6% (tinggi).Penerapan model pembelajaran discovery learning dapat meningkatkan hasil belajar siswa, tampak pada peningkatan dari tes dengan kondisi awal 50 (rendah), meningkat menjadi 80 (tinggi) pada siklus I, kemudian pada siklus II meningkat menjadi 85 (tinggi).
Peningkatan Keaktifan Siswa dengan Media Powerpoint Siswa Kelas IV SDN 2 Kemiri Boyolali
Authors: Pertiwi Prathidina , Zifa Minsih , Fatimah Siti 
Published: February 2023

Penelitian ini bertujuan untuk meningkarkan keaktifan siswa dengan media powerpoint siswa kelas IV SDN 2 Kemiri Boyolali. Penelitian ini menyajikan sebuah laporan penelitian pada peningkatan keaktifan siswa dalam pembelajaran dengan menggunakan media powerpoint. Penelitian ini adalah penelitian deskriptif kualtitatif dengan jumlah 23 siswa kelas IV SDN 2 Kemiri Boyolali. Metode pengumpulan data yang digunakan yaitu observasi, tes, dan dokumentasi. Hasil penelitian menunjukkan bahwa media powerpoint dapat meningkatan keaktifan siswa pada kelas IV SD Negeri 2 Kemiri tahun pelajaran 2020/2021. Hal ini dapat dilihat dari keaktifan siswa kelas IV sebesar 43,47%. Setelah dilakukan tindakan, hasil keaktifan siswa meningkat menjadi 65,21% dan 82,60% siswa mencapai KKM. Peneliti menyarankan agar guru memfasilitasi proses pembelajaran sehingga siswa dapat aktif selama proses pembelajaran dan hasil belajar siswa meningkat.
Nutritional Status of Three Tribal Populations of Jharkhand State in Relation to Environmental Conditions
Authors: Pandey B. N. , Das P.K. L. , Ijha A. K. , Jhas A. K. 
Published: February 2023

The present study was carried out to find out the nutritional status of three tribal populations- Santhal, Ho and Bhumij, inhabiting in different environmental conditions i.e. industrialized and dense forested regions of Jharkhand State. The Population inbabiting in industrialized region have least calorific intake (Santhal- 1967.
25 K.Cal: Ho- 2003.20 K.Cal. and Bhumij-1942. 11 K.Cal) than the population of dense forested region (2553.
30 K.Cal. Ho-2426.86 K.Cal. and Bhumij 2008.18 K.Cal.}. No doubt, industrialization provides better opportunities to earn money but its major portion is wasted on the elevation of so called standard of living and the Theka (Wine shop) besides, immigration among tribal also resulted in changed nutritional as well as calorific intake. The diet of these tribal populations is inadequate as per Indian standards. The deficiency in diet is both qualitative and quantitative, as a result population suffers from a large number of nutritional disorders like anemia, night blindness, bigot spot etc. on the basis of the study it is suggested that a short term training programme should be launched at Panchayat level to provide knowledge of balanced diet or essential nutrients of the food as per requirements of Men, Women and children.
Water Quality Management: Strategies for Conservation of Bhopal Waters
Authors: Garg Jaya , Garg H.K. 
Published: February 2023

The city of Bhopal is crowned with lakes and reservoirs, which are major sources of potable water, recreational activities and aquaculture. These reservoirs are under great environmental stress due to agricultural run offs, human encroachments, siltation and growth of aquatic needs. In order to maintain Upper lake as a healthy water- resource for drinking purposes, lower lake as a recreational ground for boating, water games, tourism and surface transport and Shahpura reservoir as a pisciculture station, an attempt has been made to formulate certain measures, that can cure the already spoilt lakes and check the water sheds from getting eutrophicated.
Kehamilan Aman dan Nyaman dengan Pendampingan di Kelas Ibu Hamil Puskesmas Jenggot Kota Pekalongan
Authors: Prajayanti Hilda , Artanti Swasti , Andanawarih Putri 
Published: February 2023

Pregnant Women's Class is a study group for pregnant women with gestational age between 4 weeks to 36 weeks (before delivery). Safe and comfortable pregnancy is one of the stages of life that must be prepared by a woman, in the process of pregnancy there are physiological and psychological changes due to an increase in estrogen and progesterone. Risk factors for maternal mortality during the delivery process begin with an unmonitored pregnancy. Efforts to reduce maternal mortality through maternity classes. This pregnant women class is a means to learn together about health for pregnant women, in the form of face-to-face in groups aimed at increasing the knowledge and skills of mothers regarding pregnancy, pregnancy care, childbirth, postpartum care, newborn care, myths, infectious diseases and birth certificates. The purpose of this community service is to increase the knowledge of pregnant women about pregnant women's classes. The method of providing material presented is (1) Newborn care for optimal growth and development and body mechanics, (2) safe delivery, safe postpartum, safe mother and healthy baby, (3) danger signs for pregnant women in Trimester III. Evaluation of the results of pregnant women's class activities with Post Test. The results of this activity can increase the knowledge and understanding of participants about the importance of pregnant women's classes so that they can maintain health during pregnancy and prevent / detect early if complications occur in pregnancy.