bluuebunny/crossref_metadata_2025_split huggingface dataset:
SYVN1 ubiquitinates FoxO1 to induce β-catenin nuclear translocation, PD-L1-mediated metastasis, and immune evasion of hepatocellular carcinoma
Authors: Xie Wei , Shi Lei , Quan Hu , Xiao Hua , Chen Jie , Liu Jia , de Dieu Habimana Jean , Huang Rongqi , Luo Jia , Chen Pan , Li Zhiyuan 
Published: April 2023

Abstract
Background
A high incidence of hepatocellular carcinoma (HCC), the most frequently diagnosed form of liver cancer, is observed in Africa and Asia. SYVN1 is upregulated in HCC; however, the biological roles of SYVN1 in immune evasion remain unclear.

Methods
RT-qPCR and western blot were employed to detect the expression levels of SYVN1 and the key molecules in HCC cells and tissues. Flow cytometry was used to determine the proportion of T cells, and an ELISA assay was used to determine the amount of IFN-γ secreted. Cell viability was monitored by CCK-8 and colony formation assays. The metastatic properties of HCC cells were detected by Transwell assays. Bioinformatics analysis, ChIP, and luciferase assays were used to study the transcriptional regulation of PD-L1. Co-IP was used to detect direct interaction between SYVN1 and FoxO1, as well as the ubiquitination of FoxO1. The in vitro findings were validated in xenograft and lung metastasis models.

Results
In HCC cells and tissues, SYVN1 was upregulated while FoxO1 was downregulated. SYVN1 knockdown or FoxO1 overexpression reduced PD-L1 expression, and inhibited immune evasion, cell growth, and metastasis in HCC cells. Mechanistically, FoxO1 regulated PD-L1 transcription in a β-catenin-independent or -dependent manner. Functional studies further showed that SYVN1 promoted immune evasion, cell proliferation, migration and invasion via facilitating ubiquitin-proteasome-dependent degradation of FoxO1. In vivo investigations showed that silencing of SYVN1 inhibited immune evasion and metastasis of HCC cells, possible via the FoxO1/PD-L1 axis.

Conclusion
SYVN1 regulates FoxO1 ubiquitination to stimulate β-catenin nuclear translocation and promotes PD-L1-mediated metastasis and immune evasion in HCC.
Comprehensive modeling strategy for thermomechanical tribological behavior analysis of railway vehicle disc brake system
Authors: Yin Jiabao , Lu Chun , Mo Jiliang 
Published: April 2023

AbstractA comprehensive modeling strategy for studying the thermomechanical tribological behaviors is proposed in this work. The wear degradation considering the influence of temperature (T) is predicted by Archard wear model with the help of the UMESHMOTION subroutine and arbitrary Lagrangian–Eulerian (ALE) remeshing technique. Adopting the proposed method, the thermomechanical tribological behaviors of railway vehicle disc brake system composed of forged steel brake disc and Cu-based powder metallurgy (PM) friction block are studied systematically. The effectiveness of the proposed methodology is validated by experimental test on a self-designed scaled brake test bench from the perspectives of interface temperature, wear degradation, friction noise and vibration, and contact status evolution. This work can provide an effective way for the investigation of thermomechanical tribological behaviors in the engineering field.
A Survey of Advanced Information Fusion System: from Model-Driven to Knowledge-Enabled
Authors: Zhu Di , Yin Hailian , Xu Yidan , Wu Jiaqi , Zhang Bowen , Cheng Yaqi , Yin Zhanzuo , Yu Ziqiang , Wen Hao , Li Bohan 
Published: April 2023

AbstractAdvanced knowledge engineering (KE), represented by knowledge graph (KG), drives the development of various fields and engineering technologies and provides various knowledge fusion and knowledge empowerment interfaces. At the same time, advanced system engineering (SE) takes model-based system engineering (MBSE) as the core to realize formal modeling and process analysis of the whole system. The two complement each other and are the key technologies for the transition from 2.0 to 3.0 in the era of artificial intelligence and the transition from perceptual intelligence to cognitive intelligence. This survey summarizes an advanced information fusion system, from model-driven to knowledge-enabled. Firstly, the concept, representative methods, key technologies and application fields of model-driven system engineering are introduced. Then, it introduces the concept of knowledge-driven knowledge engineering, summarizes the architecture and construction methods of advanced knowledge engineering and summarizes the application fields. Finally, the combination of advanced information fusion systems, development opportunities and challenges are discussed.
“Evaluation of an electromagnetically actuated drum brake concept”
Authors: Guckes Lennart , Hoffmann Jens , Schrimpf Malte , Winner Hermann 
Published: April 2023

AbstractIn publications and conferences on the subject of wheel brakes, different concepts of electromechanically actuated wheel brakes can be found, as well as investigations into their suitability for the use in passenger cars. The vast majority of these brakes are disc or drum brakes, which are actuated by an electric motor. In the present publication, a brake concept is considered, that combines an electromagnetically actuated full-pad disc brake with a 10″ duo-duplex drum brake. The brake concept is researched in a project regarding brakes for autonomous shuttles and thus dimensioned using vehicle data of an example shuttle. The electromagnet was designed using finite element methods and the overall brake prototypically realized. The validation of the system design is carried out in component and system tests. The results show the suitability of the concept for the selected vehicle in terms of dynamics, installation space and energy requirements. However, there is a strong dependence of the braking torque output on the frictional sliding speed. Using hypothesis-based testing, electromagnetic effects like eddy currents are ruled out as a possible cause and the friction coefficient within the full-pad disc brake is identified as the main cause for the loss in torque. Consequently, the associated development conflict is identified and lies in the double function of the flux-carrying material in the electromagnet, which also acts as a friction partner for the braking disc.
A geo-spatial assessment of drought impacts on forest cover in yabello forest, in the semi-arid region of Ethiopia
Authors: Wolteji Bayisa Negasa , Garbaba Fayera Gizawu 
Published: April 2023

Abstract
Drought is a key challenge for third-world countries whose economies are based on agriculture. Also, lack of rainfall plays a major role in accelerating climate change. Drought is resulting in a decline in vegetation greenness and plant mortality specifically in the semi-arid region. In this study, satellite-based drought assessment was used to characterize drought and its impact on forests in the semi-arid regions of Ethiopia. Drought severity and forest cover change were detected over the period between 2014 and 2022 Using geographic information systems and remote sensing techniques. Vegetation condition index (VCI) and Normalized difference vegetation index (NDVI) were used to detect drought severity in the present study. Results of this study showed that 2017, 2015, 2022 and 2019 were the most drought years. The forest resource is significantly decreased during severe drought years. The Minimum dense forest was observed in 2017 and 2015 over a spatial extent of 193 ha and 217 ha respectively during drought years. To evaluate how precipitation deficit affects forest function, simple linear regression is performed. Results of this linear regression “R2 = 0.49 and P = 0.05” indicated that nearly 50% of forest greenness is influenced by precipitation deficit. This study suggested that remote sensing indices are very crucial to characterize drought patterns at a small “scale”, particularly in the assessment of drought impact on forest resources.

Article Highlights

Satellite indices like NDVI and VCI help to monitor the drought impact on forest cover.

When severe drought is occurred along with precipitation deficit, the forest cover is decreased.

Remote sensing data provide clear information for decision-making regarding drought's impact on the forest.
Compressibility Behavior of Bentonites by Stern Theory based on Constant Surface Charge Conditions
Authors: Das Dhanesh Sing , Tadikonda Bharat Venkata , Raja Suresh , Tripathy Snehasis 
Published: April 2023

AbstractThe compressibility behavior of clays is governed by the electrical double layer formed around the clay particles. The Gouy-Chapman diffuse double layer theory is often utilized to predict the compressibility behavior of clay minerals. The theory does not consider the effect of the size of the cations, however, and thus predicts unrealistically small void ratios for compacted bentonites under large mechanical pressures expected in high-level nuclear waste-repository applications. In this study, the Stern layer was introduced to incorporate the cation size effect in the prediction of the compressibility behavior of bentonites. The overall diffuse double-layer thickness at large pressures was much smaller than the initially assumed Stern layer thickness based on the exchangeable cation size for all the bentonites studied. A compressible Stern layer was, therefore, considered for the first time in the prediction of the compressibility behavior of bentonites. The compression behavior of the Stern layer under the applied loading is influenced by the ratio of the mid-plane to the Stern potential, which is dependent on the type and composition of the exchangeable cations on the clay surface. Stern layer compression was initiated when the potential ratio was in the range 0.65–0.75 for bentonites with various surface cation characteristics. The incorporation of cation size and a compressible Stern layer provided significant improvements over the existing models in predicting the compressibility behavior of bentonites over a wide pressure range. The compressibility data predicted by the proposed model showed very good agreement with the data measured for five bentonites from the literature in the pressure range 0.1–42 MPa.
Unraveling the role of natural and pyrogenic dissolved organic matter in photodegradation of biodegradable microplastics in freshwater
Authors: He Jiehong , Ma Weiwei , Han Lanfang , Chen Liying , Xu Elvis Genbo , Xing Baoshan , Yang Zhifeng 
Published: April 2023

AbstractBiodegradable plastic is often perceived as a possible solution for microplastic (MP) pollution. Photodegradation is an important transformation pathway of biodegradable MPs in aquatic environments. However, the influence mechanisms of dissolved organic matter (DOM) from different sources on photodegradation of biodegradable MPs are poorly understood. This study explored the role of naturally and pyrogenically sourced DOM in the photodegradation of polylactic acid (PLA) MPs. The aromatics of natural DOM (NDOM) were higher than those of biochar-sourced DOM (BDOM) and showed a stronger improvement in PLA-MPs degradation, as evidenced by particle size reduction, crystallinity increase and polymerization decrease, breakage of surface morphology, and increase in oxygen-containing functional groups on MPs’ surface (O/C increase: 65.1% for NDOM; 34.9% for BDOM). Reactive oxygen species analysis showed that the excited triplet states of DOM (3DOM*) generated by NDOM produced more •OH and 1O2 than that of BDOM, accelerating PLA-MPs photodegradation. Such photodegradation processes were further enhanced through the sorption of DOM by PLA-MPs, in which non-aromatic components were preferentially sorbed, causing the enrichment of aromatics in the solution, leading to more 3DOM* formation. This study improves the understanding of the migration and transformation of biodegradable MPs with the presence of DOM.
Graphical Abstract
Fixed-time cooperative trajectory optimisation strategy for multiple hypersonic gliding vehicles based on neural network and ABC algorithm
Authors: Zhang X. , Liu S. , Yan J. , Liu S. , Yan B. 
Published: April 2023

AbstractCollaborative planning for multiple hypersonic vehicles can effectively improve operational effectiveness. Time coordination is one of the main forms of cooperation among multi-hypersonic glide vehicles, and time cooperation trajectory optimisation is a key technology that can significantly increase the success rate of flight missions. However, it is difficult to obtain satisfactory time as a constraint condition during trajectory optimisation. To solve this problem, a multilayer Perceptrona is trained and adopted in a time-decision module, whose input is a four-dimensional vector selected according to the trajectory characteristics. Additionally, the MLP will be capable of determining the optimal initial heading angle of each aircraft to reduce unnecessary manoeuvering performance consumption in the flight mission. Subsequently, to improve the cooperative flight performance of hypersonic glide vehicles, the speed-dependent angle-of-attack and bank command were designed and optimised using the Artificial Bee Colony algorithm. The final simulation results show that the novel strategy proposed in this study can satisfy terminal space constraints and collaborative time constraints simultaneously. Meanwhile, each aircraft saves an average of 13.08% flight range, and the terminal speed is increased by 315.6m/s compared to the optimisation results of general purpose optimal control software (GPOPS) tools.
L’invention du social ?
Authors: Gray Benjamin 
Published: April 2023

RésuméCet article applique à la Grèce antique une approche développée par Pierre Rosanvallon : l’intégration des textes philosophiques aux documents du quotidien pour mieux saisir la compréhension qu’une société a de sa vie politique. Ici, cela nécessite de se concentrer sur les sources plus pragmatiques que sont les inscriptions des villes, notamment celles portant sur les décisions civiques. Nous nous penchons sur l’évolution des idées sur la nature de la vie politique et privée, et surtout sur l’espace qui les sépare. Avec une influence considérable, les démocrates et les philosophes de l’Athènes classique ont eu tendance à insister sur une distinction binaire nette entre vie publique/politique et vie privée, laissant peu de place à la notion d’un troisième espace intermédiaire de la vie de la polis, semblable à une « sphère sociale » ou à une « société civile ». Ce modèle est resté dominant pendant les périodes hellénistique et romaine, mais, surtout après 150 av. J.-C. environ, certains citoyens et intellectuels grecs ont développé, principalement dans les inscriptions, une notion beaucoup plus explicite, complexe et subtile de « vie sociale », entre la politique et la vie privée. L’article s’interroge finalement sur ce que les différents concepts antiques discutés peuvent apporter aux débats historiographiques actuels sur la nature de la cité grecque après 150 av. J.-C., en particulier sur la manière de dépasser l’image traditionnelle de la « dépolitisation », et remet également en question le récit orthodoxe du développement des idées du « social » sur plusieurs siècles jusqu’à aujourd’hui.
Independent Publishing in Angola, Mozambique, Cape Verde, and Guinea-Bissau
Authors: Stella Marcello G. P. 
Published: April 2023

AbstractFocusing on the work of independent publishers in Lusophone Africa, this article investigates the strategies undertaken by the publishers to develop their catalog and run a publishing house in challenging environments. My examples will be drawn from ongoing initiatives by Filinto Elísio and Márcia Souto (Rosa de Porcelana, Cape Verde), Miguel de Barros and Tony Tcheca (Corubal, Guinea-Bissau), Abdulai Sila (Kusimon, Guinea-Bissau), Luiz Vicente (Nimba Edições, Guinea-Bissau/Portugal), Ondjaki (Kacimbo, Angola), Mbate Pedro, Jessemusse Cacinda, Sandra Tamele, and Dany Wambire (Cavalo do Mar, Ethale Books, Trinta Zero Nove, and Fundza, respectively, Mozambique). Although most scholarship on Luso-African writing has been devoted to the form and content of these literatures, there has been scant attention to the socio-history of publishers.
The Luso-African Literary World: Introduction
Authors: Helgesson Stefan , Stella Marcello G. P. 
Published: April 2023

AbstractWith reference to the five articles in the special issue, this introduction reflects on the relative absence of Lusophone African literature from the mainstream of African literary studies. Because of the insular and backward nature of Portugal’s colonialism, the protracted wars in Angola and Mozambique, and the sheer magnitude of the postcolony of Brazil as a center for the reception of Lusophone writing, this literature has followed a path of its own. However, although a fair amount of scholarly attention has been paid to the early anticolonial and nationalist generations of writers, this special issue updates the account of the Luso-African literary world by looking also at current developments in publishing (locally and abroad) and reception, especially in Brazil.
Ballot Reform, the Personal Vote, and Political Representation in the United States
Authors: Moskowitz Daniel J. , Rogowski Jon C. 
Published: April 2023

AbstractTheories of electoral accountability emphasize voters' ability to evaluate individual officeholders, which incentivises officials to demonstrate their quality. Before the Australian ballot was introduced in the US at the turn of the twentieth century, however, most ballot designs constrained voters' ability to distinguish individual candidates. Previous scholarship argues that ballot reform led to the rise of candidate-centred politics and the decline in party influence in the twentieth century. We reassess the evidence for this claim and implement the most comprehensive analysis to date on the secret ballot's effects on outcomes related to distributive politics, legislator effort, and party influence. Using an improved research design, we find scant evidence that ballot reform directly affected legislator behaviour, much less that it transformed political representation. While the Australian ballot may have been a necessary condition for the eventual rise of candidate-centred politics, ballot reform did not by itself reshape American politics.
Awareness and attitude of ENT surgeons towards various dental implants or oral surgery procedures: a cross-sectional survey in the UK
Authors: Mosea A , Bella M H , Thamer M 
Published: April 2023

AbstractObjectiveTo assess the level of awareness and attitude of ENT surgeons towards dental implants and oral surgery procedures that involve the maxillary sinus.MethodsA cross-sectional survey was conducted using a closed-ended questionnaire on 40 UK-based ENT surgeons.ResultsWithin the study population, 45 per cent of ENT surgeons were not aware of sinus lift augmentation in implant dentistry. Only 25 per cent of respondents were aware of the two subtypes of sinus lift techniques. Thirty per cent of the respondents were aware of or had heard of benign positional paroxysmal vertigo following dental treatment. Fifty-two per cent of respondents came across a dental foreign body, most commonly a tooth that had been displaced into the maxillary sinus. It was also reported that 82.5 per cent of respondents had liaised with an oral surgeon for an oroantral communication problem or a dental infection.ConclusionDental awareness among ENT surgeons needs to be raised for optimum interdisciplinary communication and patient safety.
First confirmed records of white-coat pups of the Endangered Caspian seal Pusa caspica on the coast of Iran
Authors: Shirazi Amir S. , Qashqaei Ali T. , Faezi Samaneh , Khaleghi Seyedreza , Moghaddamipour Nikta , Ebrahimi Tara , Hassan Shadi Karbalaei , Chilvers B. Louise 
Published: April 2023

AbstractThe endemic Caspian seal Pusa caspica breeds on land-fast ice or stable drift ice in the northern Caspian Sea. Breeding has rarely been reported in the ice-free south-eastern Caspian Sea. Five carcases of white-coat Caspian seal pups were recovered from the southern Caspian Sea, Iran, during 2019–2022. From survey interviews, two white-coat Caspian seal pups were also observed in Amirabad and between Ghorogh and Rudsar. These records represent very late pupping dates compared to normal pupping periods. Coastal Iran should be surveyed annually for Caspian seal pups to determine frequency of breeding and areas of importance identified in the Iran Caspian Seal Action Plan.
Labour market integration among young adults diagnosed with attention-deficit/hyperactivity disorder (ADHD) at working age
Authors: Chen Lingjing , Mittendorfer-Rutz Ellenor , Björkenstam Emma , Rahman Syed , Gustafsson Klas , Kjeldgård Linnea , Ekselius Lisa , Taipale Heidi , Tanskanen Antti , Helgesson Magnus 
Published: April 2023

AbstractThe aims were to investigate patterns of labour market integration following an adult diagnosis of attention-deficit/hyperactivity disorder (ADHD) and its relation to sociodemographic factors and comorbid disorders.MethodsMultiple Swedish nationwide registers were used to identify 8045 individuals, aged 20–29, with an incident diagnosis of ADHD 2006–2011. Labour market integration was conceptualized according to the core-peripheral model as a continuum from a strong (core) to a weak (peripheral) connection to the labour market. Sequence analyses categorized clusters of labour market integration, from 1 year before to 5 years after their ADHD diagnosis for individuals diagnosed with ADHD and a matched control group without ADHD. Multinomial logistic regression computed odds ratios (ORs) with 95% confidence intervals (CIs) between sociodemographic factors and comorbid disorders and the identified clusters.ResultsAbout one-fourth of the young adults diagnosed with ADHD belonged to clusters characterized by a transition to a mainly peripheral labour market position, which was approximately four-times higher compared to controls without ADHD. Foremost, those living in small cities/villages (OR 1.9; CI 1.5–2.2), those having comorbid autism-spectrum disorder (OR 13.7; CI 6.8–27.5) or schizophrenia/psychoses (OR 7.8; CI 3.8–15.9) were associated with a transition towards a peripheral labour market position throughout the study period. Those with a high educational level (OR 0.1; CI 0.1–0.1), and men (OR 0.7; CI 0.6–0.8) were less likely to have a peripheral labour market position.ConclusionsYoung adults diagnosed with ADHD are four-times more likely to be in the peripheral labour market position compared to those without ADHD. To increase labour market participation, special attention is warranted to those with low educational level, those living outside big cities and those with comorbid mental disorders.
A super-heterodyne passive 35 GHz millimeter-wave imaging system for detecting hidden objects
Authors: Khosousi Sani Hamideh , Mohanna Shahram , Askarpour Amir Nader 
Published: April 2023

AbstractPassive millimeter-wave imaging systems (PMWIS) are employed for detecting concealed objects by mapping millimeter waves emitted from materials or living tissues. The emitted waves are measured by a receiver or radiometers without employing external wave sources. In this paper, a new super-heterodyne receiver front-end of a PMWIS at 35 GHz with an even order band pass filter is simulated and implemented. The receiver has a suitable temperature resolution for the use of hidden object imaging, is integrated and lightweight assembled on one-layer board. It has a bandwidth of 1.5 GHz, a noise figure (NF) of 2.2, and a temperature resolution of 0.126 K. The even order filter is implemented based on the substrate-integrated waveguide (SIW) technology, with Chebyshev response. The filters are designed at the central frequency of 35 GHz with the bandwidth of 1.5 GHz and one of them has controllable transmission zeroes. The filters are made by printed circuit board technology, employing SIW as resonators, having a high-quality factor of 23.33. Additionally, a triple-stage radio frequency (RF) low noise amplifier has been implemented having the specification of: RF 34.25–35.75 GHz; bandwidth 1.5 GHz; gain >60 dB; NF <2.3 dB, which are better indexes compared to some other works.