bluuebunny/crossref_metadata_2025_split huggingface dataset:
POLRMT over‐expression is linked to WNT/beta‐catenin signaling, immune infiltration, and unfavorable outcomes in lung adenocarcinoma patients
Authors: Huang Yongkang , Qian Yajuan , Xing Yufei , Pei Yongjian , Zhang Beilei , Li Ting , Pan Xue , Zhong Anyuan , Du Juan , Zhou Tong , Shi Minhua 
Published: June 2023

AbstractBackgroundMitochondrial RNA polymerase (POLRMT) is essential for the expression of mitochondrial genes. In recent studies, POLRMT expression promoted non‐small cell cancer cell proliferation in cell lines and xenografts. The present study investigated the impact of POLRMT expression and function on lung adenocarcinoma (LUAD) patients.MethodMulti‐omics data (genomics, transcriptomics, and proteomics) from publicly available databases were used to assess the role of POLRMT expression and function in LUAD. These findings were further verified using cancer tissues from clinical samples.ResultsPOLRMT was over‐expressed in LUADs, with mutation frequencies ranging from 1.30% to 5.71%. Over‐expression of POLRMT was associated with an abnormal clinicopathological condition resulting in a decreased lifespan. Furthermore, gene sets enrich analysis revealed that POLRMT expression was linked to WNT/beta‐catenin signaling; the expression of downstream target genes was positively correlated with POLRMT expression. Also, POLRMT expression was positively correlated with immunosuppressive genes, thereby affecting immune infiltration.ConclusionPOLRMT is over‐expressed in LUAD, thereby impacting patient survival. It is also involved in WNT/beta‐catenin signaling and may affect tumor infiltration.
Synthesis, Characterization, Antimicrobial and Antimalarial Activities of Azines Based Schiff Bases and their Pd(II) Complexes
Authors: Meena Kiran , Kumar Baroliya Prabhat 
Published: June 2023

AbstractHerein, we report synthesis, characterization, antimicrobial and antimalarial activities of azines Schiff base ligands (L1−L4) and their palladium (II) complexes (C1−C4) of [Pd(L)(OAc)2] type. The azine ligands (L1−L4) were prepared by condensation of carbonyl compounds with hydrazine hydrate and their complexes by the reaction of palladium acetate with L1−L4ligands in 1 : 1 molar ratio. The prepared ligands and their complexes were characterized by spectral characterization using1H &13C‐NMR, FT‐IR and mass spectral studies, which revealed that the ligands coordinatesviaazomethine nitrogen and heteroatom or aryl carbon with palladium. Moreover, Schiff bases and their palladium (II) complexes have been screened for their antibacterial (S. aureus,B. subtillis, andS. typhi,P. aeruginosa), antifungal (C. albicans,A. niger,and A. clavatus) and antimalarial (P. falciparum) activities. The Schiff baseL4showed good results for antibacterial againstS. aureus(MIC, 50 μg/mL) and antimalarial againstP. falciparum(IC50, 0.83 μg/mL). The complexC1showed best antibacterial activity (MIC, 62.5 μg/mL) againstS. typhiand the complexC4exhibited remarkable antimalarial activity (IC50, 0.42 μg/mL) among the tested compounds. Thus, azines based ligands and their Pd complexes can be good antimicrobial and antimalarial agents if explored further.
Separation of Antioxidant‐Rich Alternanthera Sessilis Red Extracts by Sephadex LH‐20 and Identification of Polyphenols Using HPLC‐QToF‐MS/MS
Authors: Hwong Chia Shing , Leong Kok Hoong , Aziz Azlina Abdul , Kong Kin Weng 
Published: June 2023

AbstractThis study aimed to fractionate Alternanthera sessilis Red (ASR) crude extracts and determine their antioxidant activities as well as the related active components in the whole plant. ASR was extracted with water and ethanol, and further separated using a Sephadex LH‐20 column. Following the assessments of the polyphenolic contents and antioxidant activities of crude extracts (H2OASR and EtOHASR) and fractions, a HPLC‐QToF analysis was performed on the crude extracts and selected fractions (H2OASR FII and EtOHASR FII). Three water fractions (H2OASR FI, FII and FIII) and four ethanolic fractions (EtOHASR FI, FII, FIII and FIV) were derived from their crude extracts, respectively. EtOHASR FII exhibited the greatest total phenolic content (120.41 mg GAE/g fraction), total flavonoid content (223.07 mg RE/g fraction), and antioxidant activities (DPPH IC50=159.43 μg/mL; FRAP=1.93 mmol Fe2+/g fraction; TEAC=0.90 mmol TE/g fraction). Correlation analysis showed significant (p<0.01) positive correlations between both TPC (r=0.748–0.970) and TFC (r=0.686–0.949) with antioxidant activities in the crude extracts and fractions. Flavonoids were the major compounds in the four selected samples tentatively identified using HPLC‐QToF‐MS/MS, with the highest number of 30 polyphenol compounds detected in the most active fraction, EtOHASR FII.
Noble Metals in Recent Developments of Heterogeneous Catalysts for CO2Conversion Processes
Authors: Vieira Luiz H. , Rasteiro Letícia F. , Santana Cássia S. , Catuzo Gabriel L. , da Silva Alisson H. M. , Assaf José M. , Assaf Elisabete M. 
Published: June 2023

AbstractFollowing the advances in capture technologies, CO2utilization associated with low‐cost renewable H2in catalytic hydrogenation is a promising strategy for reducing the carbon footprint of industrial processes by providing valuable chemicals and fuels. However, the scalability and economic viability of these processes will depend on the development of efficient catalysts. Noble metal‐based catalysts have been extensively reported in the last few years as highly effective in promoting CO2hydrogenation to various products. Although promising, the scarcity, high cost, and environmental impact of mining make it challenging to scale up these materials from bench to plant. Developing advanced synthesis and characterization methods is essential to control and understand active sites’ behavior during the reaction, providing high activity and durability. This review carefully summarizes the recently reported noble metal‐based heterogeneous catalysts for thermocatalytic conversion of CO2into methane, carbon monoxide, methanol, formic acid, higher alcohols, C2+hydrocarbons, and syngas through dry reforming of CH4, to draw the state‐of‐the‐art development in the field. Finally, we critically discuss the impact of these elements on catalyst properties, the challenges related to their implementation, and future research opportunities.
Allosteric Tuning of Caspase‐7: Establishing the Nexus of Structure and Catalytic Power
Authors: Hobbs Kathryn F. , Propp Jonah , Vance Nicholas R. , Kalenkiewicz Andrew , Witkin Katie R. , Spies M. Ashley 
Published: June 2023

AbstractInvited for the cover of this issue is the group of Michael Ashley Spies at the University of Iowa. The image depicts how mapping allosteric structure–activity relationships reveals the nexus between the active site and the remote allosteric pocket. Read the full text of the article at 10.1002/chem.202300872.
Tiefkalt auf Kurs
Authors: Homburg Claudia 
Published: June 2023

AbstractLNG und LPG gehören zu den Schweröl‐Alternativen in der Schifffahrt. Um den Tank‐Füllstand in LNG‐Container‐, Kreuzfahrtschiffe und Fähren zu messen, sind besonders kälte‐unempfindliche Füllstandsensoren mit 80 GHz‐Radar‐Messtechnik geeignet.
Sichere Prozesse im Prüflabor
Authors: Kamke Alexander , Diel Thomas , Karbowiak Marvin 
Published: June 2023

AbstractPrüflabore für chemische Sensoren müssen zuverlässige Ergebnisse liefern und die Prüfstände müssen je nach Anforderung des Auftraggebers zügig umgerüstet werden können. Die Unternehmen Reiss aus Weinheim und Jumo aus Fulda haben eine Lösung entwickelt, die hohe Prozesssicherheit bietet. Mit ihr lässt sich die unternehmenseigene Hardware einsetzen und bedienerfreundliche und flexibel neu programmieren.
Early bird gets the network: The relative importance of reactivity ratios, Ψ parameter, and crosslinker level on gel formation in FRP
Authors: Lin Yung‐Chun , Liu Chang , Tripathi Amit K. , Tsavalas John G. 
Published: June 2023

AbstractNetwork topology is manipulated in free‐radical copolymerization via proper selection of crosslinker type and its respective properties when paired with specific monomers. Our prior work has focused on the impact of the reduced reactivity parameter Ψ applied to a pendent vinyl, characteristic for each monomer/crosslinker pair, yet here we assess the relative importance of the comonomer reactivity ratios to see whether one factor can counterbalance the other. The traditional reactivity ratio determines when the crosslinker molecule is incorporated into the polymer backbone, while the reduced reactivity Ψ parameter relates to the efficiency of the resulting pendent side chain vinyl being utilized to form a crosslink node at some later point during the polymerization. Both factors are then contrasted with simply the overall loading of crosslinker. Either n‐butyl methacrylate (n‐BMA) or styrene (STY) was chosen as a primary backbone monomer to copolymerize with one of three crosslinkers: 1,4‐butanediol dimethacylate (BDDMA), 1,4‐butanediol diacrylate (BDDA), or divinylbenzene (DVB). Both kinetics and gel can be most dramatically boosted when a crosslinker is applied having a reactivity ratio favouring early insertion. This in turn leads to an earlier onset of gel formation, which ultimately results in greater final gel content. This amplification of both kinetics and gel can overcome an otherwise small Ψ due to crosslinker or main monomer choice. This reactivity ratio effect was further confirmed by Monte Carlo simulations. By whatever mechanism (higher Ψ, lower rA, or higher crosslinker level), earlier onset of gelation produces more gel overall and a tighter network topology.
Using polymer adsorption data and a population balance model to estimate how polymer dosage affects the flocculation of oil sands tailings
Authors: Dixon Daniel V. , Soares João B. P. 
Published: June 2023

AbstractPopulation balance models can describe how particles aggregate and fragment during the flocculation of mineral tailings. We used a new method to estimate some of the parameters in a population balance model describing the flocculation of oil sands mature fine tailings with poly(vinyl benzyl trimethylammonium chloride). Differently from previous population balance models, the polymer adsorption data onto the particles suspended in the tailings were used to estimate a fundamental parameter relating polymer dosage to the mean diameter of the aggregates formed during flocculation. The model could predict the flocculation behaviour of three polymer samples with different molecular weights. This model is another step toward a quantitative understanding of how polymer properties affect the flocculation of mineral tailings.
Phenanthroline Derivatives as Efficient Organic Photocatalysts for Visible‐Light‐Mediated PET‐RAFT Polymerization
Authors: Xiao Yang , Hu Wanchao , Xia Zhinan , Shi Bingfeng , Lü Changli 
Published: June 2023

Comprehensive SummaryPhenanthroline is an excellent and stable π‐electron acceptor with a large conjugated chromophore. Phenanthroline derivatives are widely used in adsorption, photodegradation, solar cells, biology, and so on. At present, there are still limited organic molecules utilized to efficiently photocatalyze reversible‐deactivation radical polymerization (RDRP). Therefore, the design of organic photocatalysts (OPCs) for RDRP remains a challenge. Herein, according to the strategy of combining the donor groups and weak acceptor groups, donor‐acceptor (D‐A) type OPCs based on phenanthroline were utilized for the first time in photoinduced electron transfer‐reversible addition‐fragmentation chain transfer (PET‐RAFT) polymerization. 1,10‐Phenanthroline‐5‐amine (Aphen) with a donor group‐amino was screened out for efficacious photo‐controlled radical polymerization under blue light for various monomers with conjugated and unconjugated structures with high monomer conversion and well‐defined narrow dispersity polymers (Đ < 1.20). Controllable homo‐polymers and block copolymers were successfully realized by chain extension reaction and block copolymerization of structurally diverse monomers.
The effect of therapist characteristics on the use and outcome of systematic client feedback in outpatient mental healthcare
Authors: Bovendeerd Bram , de Jong Kim , de Groot Erik , Moerbeek Mirjam , Hafkenscheid Anton , de Keijser Jos 
Published: June 2023

AbstractObjectiveTherapist characteristics are known to affect treatment outcome in general and could also influence the use of systematic client feedback (SCF). The current study explores the effect of feedback orientation, regulatory focus, self‐efficacy, attitude towards feedback resources and perceived feedback validity on the use and outcome of SCF in outpatient mental healthcare.MethodThe data of therapists (n = 12) and patients (n = 504) of two outpatient centres offering brief psychological treatment were analysed when SCF, based on the Partners for Change Outcome Management System (PCOMS), was added to treatment as usual. The data of therapists were obtained through a therapist questionnaire composed of relevant characteristics from feedback studies in social and organizational psychology. The effect on the use of SCF was analysed using logistic regression; whereas, the effect on outcome was assessed using a two‐level multilevel analysis. Regular use of SCF and the Outcome Questionnaire (OQ‐45) were used as outcome variables. DSM‐classification, sex and age of each patient were included as covariates.ResultsHigh perceived feedback validity significantly increased the use of SCF. No significant therapist characteristics effects were found on outcome, but high promotion focus was associated with treating more complex patients.ConclusionsThe perceived feedback validity of SCF is likely to have an influence on its use and is probably affected by the changes in the organizational climate.
Achieving sustainable business: The nexus between external sustainability assurance, CSR strategy and emission reduction
Authors: Issa Ayman , Hanaysha Jalal Rajeh 
Published: June 2023

AbstractThis study investigates the relationship between firm's emissions reduction initiative and external assurance of sustainability performance, as well as the moderating effect of corporate social responsibility (CSR) strategy. The study uses a sample of non‐financial firms listed on the STOXX Europe 600 index from 2006 to 2021. The findings suggest that external assurance of sustainability has a positive and significant impact on a firm's emissions reduction initiative. Additionally, the study finds that CSR strategy positively moderates the relationship between firm's emissions reduction initiative and external assurance of sustainability. The study's results have implications for managers, regulators, and stakeholders, indicating that external auditing for sustainability can enhance a firm's legitimacy and reputation and that strong CSR strategies can enhance the effectiveness of environmental initiatives. Our results demonstrate resilience to various econometric methods, sub‐sample analyses, propensity score matching, and generalized method of moments (GMM).
Mechanochemistry toward Organic “Salt” via Integer‐Charge‐Transfer Cocrystal Strategy for Rapid, Efficient, and Scalable Near‐Infrared Photothermal Conversion
Authors: Chen Shun‐Li , Zhang Meng‐Meng , Chen Jiecheng , Wen Xinyi , Chen Wenbin , Li Jiayu , Chen Ye‐Tao , Xiao Yonghong , Liu Huifen , Tan Qianqian , Zhu Tangjun , Ye Bowei , Yan Jiajun , Huang Yihang , Li Jie , Ni Shaofei , Dang Li , Li Ming‐De 
Published: June 2023

AbstractInspired by the concept of ionic charge‐transfer complexes for the Mott insulator, integer‐charge‐transfer (integer‐CT) cocrystals are designed for NIR photo‐thermal conversion (PTC). With amino‐styryl‐pyridinium dyes and F4TCNQ (7,7’,8,8’‐Tetracyano‐2,3,5,6‐tetrafluoroquinodimethane) serving as donor/acceptor (D/A) units, integer‐CT cocrystals, including amorphous stacking “salt” and segregated stacking “ionic crystal”, are synthesized by mechanochemistry and solution method, respectively. Surprisingly, the integer‐CT cocrystals are self‐assembled only through multiple D−A hydrogen bonds (C−H⋅⋅⋅X (X=N, F)). Strong charge‐transfer interactions in cocrystals contribute to the strong light‐harvesting ability at 200–1500 nm. Under 808 nm laser illumination, both the “salt” and “ionic crystal” display excellent PTC efficiency beneficial from ultrafast (∼2 ps) nonradiative decay of excited states. Thus integer‐CT cocrystals are potential candidates for rapid, efficient, and scalable PTC platforms. Especially amorphous “salt” with good photo/thermal stability is highly desirable in practical large‐scale solar‐harvesting/conversion applications in water environment. This work verifies the validity of the integer‐CT cocrystal strategy, and charts a promising path to synthesize amorphous PTC materials by mechanochemical method in one‐step.
Experimental investigation on hybrid cooled lithium‐ion battery pack with 3S4P cell configuration using OM 48 as phase change material and heat pipe
Authors: Wankhede Sagar , More Kiran , Kamble Laxman , Thorat Prajwal 
Published: June 2023

AbstractBecause of their high energy capacity and power density, lithium‐ion batteries are an essential component of electric and hybrid vehicles; however, they frequently experience excessive temperature rise because of heat creation inside the batteries. The charge state and charge/discharge rate play a major role in this heat generation. Due to its high latent heat, compact design and lightweight nature without requiring any external power, passive techniques like phase change material (PCM) and heat pipe (HP) cooling have gained widespread popularity. Therefore, this work focussed on hybrid BTMS integrating Heat Pipe with PCM for better thermal management of battery pack supported by a heat pipe that is used to analyse the thermal performance of a battery module having three and four lithium‐ion batteries placed in series and parallel. The objective of maintaining temperature gradient of less than 5°C between the adjacent cells and maintaining the overall battery temperature in the range of 25°C–45°C has been successfully achieved. The results of experiments at various discharge rates showed that a heat pipe was crucial to quickly transferring heat and maintaining temperature homogeneity for PCM‐based battery modules. It can be concluded that the data presented above can offer views for creating and improving battery heat management systems.
“Understand where you're coming from”: Positionality and higher education disability resources
Authors: Strimel Morgan M. , Francis Grace L. , Duke Jodi M. 
Published: June 2023

AbstractDespite their significant influence on the experiences of disabled college students, disability resource professionals are provided limited guidance on how to carry out the functions of their role. As a result, during the accommodations process, disability resource professionals generally rely on their instincts and “gut” reactions when responding to accommodation requests after quickly processing information from a student's self‐report and relevant medical documentation. However, hidden within these quick decisions are disability resource professionals' positionalities—or frameworks for considering the world—that have an innate influence on the outcome of accommodation decisions and, ultimately, disabled students’ access to higher education. Therefore, the purpose of this study was to explore disability resource professionals’ views on positionality in the context of higher education disability resources and its relationship to accommodation decision‐making. After a review of findings from interviews with 13 disability resource professionals, the authors conclude with recommendations for higher education disability resources and directions for future research.Practical Implications
It is important for disability resource professionals to cyclically examine their positionalities (e.g., identities, experiences) before, during, and following the accommodations process and working with disabled college students.
When examining their positionalities, disability resource professionals should critically examine their positions in relation to power and privilege, with a focus on their reactions to students’ identities and experiences.
Leadership in the field of higher education disability resources should also create time and space for disability resource professionals to engage in meaningful positionality‐focused professional development opportunities.
Outcomes after definitive treatment for cutaneous angiosarcomas of the face and scalp: Reevaluating the role of surgery and radiation therapy
Authors: Yoder Alison K , Farooqi Ahsan S , Wernz Cort , Subramaniam Aparna , Ravi Vinod , Goepfert Ryan , Sturgis Erich M , Mitra Devarati , Bishop Andrew J , Guadagnolo B Ashleigh 
Published: June 2023

AbstractIntroductionWe investigated outcomes and prognostic factors for patients treated for cutaneous angiosarcoma (CA).MethodsWe conducted a retrospective review of patients treated for CA of the face and scalp from 1962 to 2019. All received definitive treatment with surgery, radiation (RT), or a combination (S‐XRT). The Kaplan–Meier method was used to estimate outcomes. Multivariable analyses were conducted using the Cox proportional hazards model.ResultsFor the 143 patients evaluated median follow‐up was 33 months. Five‐year LC was 51% and worse in patients with tumors >5 cm, multifocal tumors, those treated pre‐2000, and with single modality therapy (SMT). These remained associated with worse LC on multivariable analysis. The 5‐year disease‐specific survival (DSS) for the cohort was 56%. Tumor size >5 cm, non‐scalp primary site, treatment pre‐2000, and SMT were associated with worse DSS.ConclusionLarge or multifocal tumors are negative prognostic factors in patients with head and neck CA. S‐XRT improved outcomes.
Basic information about memantine and its treatment of Alzheimer's disease and other clinical applications
Authors: Tang Bin‐Can , Wang Ya‐Ting , Ren Jie 
Published: June 2023

AbstractMemantine is a noncompetitive moderate‐affinity strong voltage‐dependent N‐methyl‐D‐aspartate receptor antagonist. It has been used to treat Alzheimer's disease (AD) since 1989. In 2018, it became the second most commonly used drug for the treatment of dementia in the world. AD is nonreversible, and memantine can only relieve the symptoms of AD but not cure it. Over the past half‐century, memantine's research and clinical application have been extensively developed. In this review, the basic composition of memantine, the mechanism and limitations of memantine in the treatment of AD, memantine combination therapy, comparison of memantine with other drugs for AD, and clinical studies of memantine in other diseases are reviewed to provide a valuable reference for further research and application of memantine for the treatment of AD.