bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effective GH Replacement With Somapacitan in Children With GHD: REAL4 2-year Results and After Switch From Daily GH
Authors: Miller Bradley S , Blair Joanne C , Rasmussen Michael Højby , Maniatis Aristides , Mori Jun , Böttcher Volker , Kim Ho-Seong , Bang Rikke Beck , Polak Michel , Horikawa Reiko 
Published: July 2023

Abstract

Context
Somapacitan is a long-acting GH derivative for treatment of GH deficiency (GHD).

Objective
Evaluate the efficacy and tolerability of somapacitan in children with GHD after 2 years of treatment and after the switch from daily GH.

Design
A randomized, multinational, open-labelled, controlled parallel group phase 3 trial, comprising a 52-week main phase and 3-year safety extension (NCT03811535).

Setting
Eighty-five sites across 20 countries.

Patients
A total of 200 treatment-naïve prepubertal patients were randomized and exposed; 194 completed the 2-year period.

Interventions
Patients were randomized 2:1 to somapacitan (0.16 mg/kg/wk) or daily GH (0.034 mg/kg/d) during the first year, after which all patients received somapacitan 0.16 mg/kg/wk.

Main outcome measures
Height velocity (HV; cm/year) at week 104. Additional assessments included HV SD score (SDS), height SDS, IGF-I SDS, and observer-reported outcomes.

Results
HV was sustained in both groups between 52 and 104 weeks. At week 104, mean (SD) for HV between weeks 52 and 104 was 8.4 (1.5) cm/year after continuous somapacitan treatment and 8.7 (1.8) cm/year after 1 year of somapacitan treatment following switch from daily GH. Secondary height-related endpoints also supported sustained growth. Mean IGF-I SDS during year 2 was similar between groups and within normal range (−2 to +2). Somapacitan was well tolerated, with no safety or tolerability issues identified. GH patient preference questionnaire results show that most patients and their caregivers (90%) who switched treatment at year 2 preferred once-weekly somapacitan over daily GH treatment.

Conclusions
Somapacitan in children with GHD showed sustained efficacy and tolerability for 2 years, and after switching from daily GH. Patients/caregivers switching from daily GH expressed a preference for somapacitan.

Clinical Trial Registration
NCT03811535
Dietary Progesterone Contributes to Intratissue Levels of Progesterone in Male Mice
Authors: Colldén Hannah , Hagberg Thulin Malin , Landin Andreas , Horkeby Karin , Lagerquist Marie , Wu Jianyao , Nilsson Karin H , Grahnemo Louise , Poutanen Matti , Ryberg Henrik , Vandenput Liesbeth , Ohlsson Claes 
Published: July 2023

Abstract
Progesterone serum levels have been identified as a potential predictor for treatment effect in men with advanced prostate cancer, which is an androgen-driven disease. Although progesterone is the most abundant sex steroid in orchiectomized (ORX) male mice, the origins of progesterone in males are unclear.
To determine the origins of progesterone and androgens, we first determined the effect of ORX, adrenalectomy (ADX), or both (ORX + ADX) on progesterone levels in multiple male mouse tissues. As expected, intratissue androgen levels were mainly testicular derived. Interestingly, progesterone levels remained high after ORX and ORX + ADX with the highest levels in white adipose tissue and in the gastrointestinal tract. High progesterone levels were observed in mouse chow and exceptionally high progesterone levels were observed in food items such as dairy, eggs, and beef, all derived from female animals of reproductive age. To determine if orally ingested progesterone contributes to tissue levels of progesterone in males, we treated ORX + ADX and sham mice with isotope-labeled progesterone or vehicle by oral gavage. We observed a significant uptake of labeled progesterone in white adipose tissue and prostate, suggesting that dietary progesterone may contribute to tissue levels of progesterone. In conclusion, although adrenal-derived progesterone contributes to intratissue progesterone levels in males, nonadrenal progesterone sources also contribute. We propose that dietary progesterone is absorbed and contributes to intratissue progesterone levels in male mice. We speculate that food with high progesterone content could be a significant source of progesterone in males, possibly with consequences for men undergoing androgen deprivation therapy for prostate cancer.
O ρόλος της αντιληπτής οργανωσιακής κουλτούρας στη σχέση μεταξύ ηγεσίας και οργανωσιακής ταύτισης: μια πολυεπίπεδη ανάλυση
Authors: Κορώνη Σοφία K. , Ξενικού Αθηνά , Χαντζή Αλεξάνδρα 
Published: July 2023

Η παρούσα ερευνητική εργασία είχε ως στόχο να εξετάσει τη σχέση της μετασχηματιστικής και συναλλακτικής ηγεσίας με τη γνωστική και συναισθηματική ταύτιση των εργαζομένων μέσω της καλλιέργειας των οργανωσιακών αξιών υποστήριξης, καινοτομίας, στοχοθεσίας, και κανόνων. Το δείγμα της έρευνας αποτέλεσαν 367 εργαζόμενοι από 30 διαφορετικές μονάδες ενός μεγάλου δημόσιου οργανισμού. Για τον έλεγχο των ερευνητικών υποθέσεων χρησιμοποιήθηκε η πολυεπίπεδη ανάλυση (Multilevel Structural Equation Modeling, MSEM). Εξετάστηκε ηδιαμεσολάβηση της αντιληπτής καινοτομίας και υποστήριξης στη σχέση μεταξύ μετασχηματιστικής ηγεσίας και των δύο διαστάσεων της οργανωσιακής ταύτισης, όπως και η διαμεσολάβηση της αντιληπτής στοχοθεσίας και κανόνων στη σχέση μεταξύ συναλλακτικής αμοιβής βάσει επίδοσης και συναισθηματικής ταύτισης. Τα αποτελέσματα έδειξαν ότι η μετασχηματιστική ηγεσία σχετίζεται θετικά μόνο με τη γνωστική διάσταση της ταύτισης, ενώ η συναλλακτική αμοιβή βάσει επίδοσης σχετίζεται θετικά και με τις δύο διαστάσεις της ταύτισης. Η μετασχηματιστική ηγεσία βρέθηκε να σχετίζεται θετικά με την αντίληψη της κουλτούρας του οργανισμού στη βάση των αξιών της υποστήριξης, της καινοτομίας, των κανόνων και της στοχοθεσίας, ενώ η συναλλακτική αμοιβή βάσει επίδοσης σχετίζεται θετικά με τον αξιακό προσανατολισμό των στόχων και της υποστήριξης. Τα αποτελέσματα επίσης έδειξαν ότι η καινοτομία α) διαμεσολαβεί τη σχέση ανάμεσα στη μετασχηματιστική ηγεσία και τη συναισθηματική ταύτιση, αλλά αντίθετα με τις υποθέσεις μας σχετίζεται αρνητικά με τη συναισθηματική ταύτιση, και β) δεν διαμεσολαβεί τη σχέση της μετασχηματιστικής ηγεσίας με τη γνωστική ταύτιση. Επίσης, η υποστήριξη βρέθηκε να διαμεσολαβεί τη σχέση της μετασχηματιστικής ηγεσίας και με τις δύο διαστάσεις της ταύτισης. Τα ευρήματα δείχνουν ότι η ηγετική συμπεριφορά, ως μια διαδικασία κοινωνικής επιρροής, σχετίζεται με την οργανωσιακή ταύτιση κυρίως μέσω της καλλιέργειας της υποστήριξης. Τα συμπεράσματα που προκύπτουν από τα ευρήματα συζητούνται ως προς τις θεωρητικές τους προεκτάσεις και τις εφαρμογές τους στην οργανωσιακή πρακτική.
Thermal performance of gasifier cooking stoves: A systematic literature review
Authors: Rabby Md Insiat Islam , Uddin Md Wasi , Sheikh Mahafuzur Rahman , Bhuiyan Humayun Kabir , Mumu Tazeen Afrin , Islam Fabliha , Sultana Afsana 
Published: July 2023

A systematic literature review was conducted to summarize the overall thermal performance of different gasified cooking stoves from the available literature. For this purpose, available studies from the last 14 years (2008 to 2022) were searched using different search strings. After screening, a total of 28 articles were selected for this literature review. Scopus, Google Scholar, and Web of Science databases were used as search strings by applying “Gasifier cooking stove” AND “producer gas cooking stove” AND “thermal performance” keywords. This review uncovers different gasified cooking stoves, cooking fuels, and fabrication materials besides overall thermal performances. The result shows that the overall thermal performance of different gasified cooking stoves was 5.88% to 91% depending on the design and burning fuels. The premixed producer gas burner with a swirl vane stove provided the highest overall thermal performance range, which was 84% to 91%, and the updraft gasified stove provided the lowest performance, which was 5.88% to 8.79%. The result also demonstrates that the wood pellets cooking fuel provided the highest thermal performance and corn straw briquette fuel provided the lowest for gasified cooking stoves. The overall thermal performance of wood pellets was 38.5% and corn straw briquette was 10.86%.
Associated ICU nurses' characteristics to clinical enteral nutrition knowledge at public hospitals in Sana'a, Yemen: A basis for remodeling safety and quality of care standards
Authors: Ali Hussein Al-Qalah Talal , Alrubaiee Gamil Ghaleb 
Published: July 2023

Background: Nurses have a pivotal role in initiating and managing enteral nutrition (EN) and monitoring any potential complications. Yet, it is unclear whether Yemeni nurses have adequate knowledge to deliver and manage enteral nutrition safely. Therefore, the aim of this study was to assess the level of ICU nurses’ knowledge regarding the care of EN. Methods: A descriptive cross-sectional study was conducted from February 2019 to March 2019. A probability sampling method was used to recruit 174 nurses from four public hospitals in the capital city of Yemen. A self-administered 17-item questionnaire related to ICU nurses' knowledge regarding EN intervention was used to collect the data. Results: Based on our findings, only 10.9% of the respondents had an adequate level of knowledge about EN care, while 43.1% of them had a moderate level of knowledge, and 46.0% of them had an inadequate level of knowledge. Only 16.1% of the participants were knowledgeable of EN pre-administration care, whereas 5.80% of them were knowledgeable of EN administration care, and 9.20% were knowledgeable of EN post-administration care. There were significant associations between ICU nurses’ level of knowledge of EN care and their level of education and knowledge sources. Conclusions: The significant gap in ICU nurses’ knowledge regarding EN care identified implies the need to upgrade and refresh of the ICU nurses' knowledge by implementing a regular training program concerning EN care.
Culinary Culture Code in Demotivators and Modern Internet-Communication
Authors: Dimitrieva Ol'ga , Andreeva D. 
Published: July 2023

Quite a lot of works are devoted to the study of creolized texts, in which the structure of such texts is investigated, as well as their impact on the recipient, verbal features and visual characteristics are revealed. Aim. The main purpose of this study is to study the polycode creolized text of the demotivator, visually and/or verbally related to culinary and gastronomic topics, from the point of view of the value aspect and actualization of certain axiological dominants existing in the modern world.
Methodology and research methods. Demotivators thematically related to the field of gastronomy served as the material for the study. The main research methods are semantic, descriptive, as well as analysis and systematization of the material. Results. Special attention is paid to two types of demotivators: demotivators of the weight-reflexive type and those one in which social status is marked (the group is considered on the example of students). It was revealed that the first type reflects modern stereotypes about proper nutrition, harmful and healthy foods, and meal times. In the second type, the main qualities and traits of students are marked, namely, they investigate how such components as 1) poverty / affluence are displayed with the help of food, 2) hunger / satiety and connection with intellectual abilities, 3) study / work. Scientific novelty. The novelty of the work is connected with the definition of the value properties of household items, using the example of culinary / food preferences of the subject of communication, as well as with the emphasis on existing modern stereotypes and axiological guidelines in the field of nutrition and beyond. Practical significance. The materials and conclusions of this work can be used in the development of courses on media and Internet communication, lexicology and active processes of the modern Russian language.
Impact of human wound exudate on the bactericidal efficacy of commercial antiseptic products
Authors: Augustin Matthias , Herberger Katharina , Wille Andreas , Twarock Sören 
Published: July 2023

Objective: By default, the antimicrobial efficacy of antiseptics used in wound management is tested in vitro under standardised conditions according to European standard DIN EN 13727, with albumin and sheep erythrocytes used as organic challenge. However, it is not clear whether these testing conditions adequately reflect the wound bed environment and its interaction with antiseptic products intended to be used in wounds in humans. Method: This study compared the efficacy of different commercial antiseptic products based on octenidine dihydrochloride (OCT), polyhexamethylene biguanide (PHMB) and povidone-iodine under challenge with human wound exudate collected from the hard-to-heal wounds of patients, compared to the standardised organic load, in an in vitro setting according to DIN EN 13727. Results: The bactericidal efficacy of the tested products was reduced to a different extent when challenged with human wound exudate, compared to the standardised conditions. Overall, OCT-based products showed the necessary germ count reductions at the shortest exposure times (e.g., 15 seconds for Octenisept (Schülke & Mayr GmbH, Germany)). PHMB-based products were the least efficient. In addition to the protein content, other components of wound exudate, such as the microbiota, seem to influence the efficacy of antiseptics. Conclusion: This study demonstrated that the standardised in vitro test conditions may only partially reflect actual wound bed conditions in humans.
Reducing lower extremity hospital-acquired pressure injuries: a multidisciplinary clinical team approach
Authors: Pinhasov Tamir , Isaacs Shelby , Donis-Garcia Miriam , Oropallo Alisha , Brennan Mary , Rao Amit , Landis Gregg , Agrell-Kann Marie , Li Timmy 
Published: July 2023

Objective: Optimal methods of reducing incidence of hospital-acquired pressure injuries (HAPIs) remain to be determined. We assessed changes in yearly incidence of lower extremity HAPIs before and after an intervention aimed at reducing these wounds. Method: In 2012, we implemented a three-pronged intervention to reduce the incidence of HAPIs. The intervention included: a multidisciplinary surgical team; enhanced nursing education; and improved quality data reporting. Yearly incidence of lower extremity HAPIs was tracked. Results: Pre-intervention, incidence of HAPIs was 0.746%, 0.751% and 0.742% in 2009, 2010 and 2011, respectively. Post-intervention, incidence of HAPIs was 0.002%, 0.051%, 0.038%, 0.000% and 0.006% in 2013, 2014, 2015, 2016 and 2017, respectively. Mean incidence of HAPIs was reduced from 0.746% before the intervention to 0.022% after the intervention (p<0.001). Conclusion: An intervention by a multidisciplinary surgical team enhanced nursing education, and improved quality data reporting reduced the incidence of lower extremity HAPIs.
The impact of healthcare assistant education on pressure ulcer prevention: a systematic review
Authors: O'Brien Noreen , Moore Zena , Avsar Pinar , Patton Declan , Nugent Linda , O'Connor Tom 
Published: July 2023

Objective: To investigate the impact of education for healthcare assistants (HCAs) on their knowledge and skills in pressure ulcer (PU) prevention and on the incidence of PUs. A secondary aim was to evaluate education methodologies used in PU prevention programmes. Method: Using systematic review methodology, key databases were searched with no limitations on date of publication. The search was conducted in November 2021 using the following databases: CINAHL, Embase, Scopus, MEDLINE, Cochrane Wounds Group Specialist Register and Cochrane Central Register of Controlled Trials. Inclusion criteria focused on studies that employed the use of education as an intervention, delivered to HCAs in any setting. The PRISMA guidelines were followed. The methodological quality of the studies was evaluated using the Evidence-Based Librarianship (EBL) appraisal checklist. Data were analysed using narrative analysis and meta-analysis. Results: The systematic search yielded an initial 449 records, of which 14 studies met the inclusion criteria. Outcome measures of HCA knowledge scores were reported in 11 (79%) studies. Outcome measures related to PU prevalence/incidence were reported in 11 (79%) studies. An increase in knowledge scores of HCAs post-educational intervention was reported in five (38%) studies. A significant reduction in PU prevalence/incidence rates post-educational intervention was reported in nine (64%) studies. Conclusion: This systematic review affirms the benefits of education of HCAs on their knowledge and skills of PU prevention, and on PU incidence. The results must be treated with caution due to quality appraisal issues of included studies.
High-performance phase measuring profilometry architecture based on Zynq SoC
Authors: Fan Fei , Kang Jiehu , Feng Luyuan , Zhang Zhen , Yuan Leiwen , Wu Bin 
Published: July 2023

This paper presents a novel high-performance heterogeneous computation architecture, to the best of our knowledge, for stereo structure light using the phase measuring profilometry (PMP) algorithm based on a Zynq UltraScale+ system on chip (SoC). The proposed architecture aims to achieve real-time and high-accuracy 3D shape measurement. The experiment results indicate that the calculation time of a standard four-step PMP algorithm with a resolution of 1280×1024 is 14.11 ms. It is nearly 51 times faster than the well-optimized software implementation running on a Raspberry Pi and nearly three times faster than a high-end PC, with 15 times less power consumption. Consequently, the proposed architecture is deemed suitable for real-time 3D measurements in embedded applications.
Natural exceptional points in the excitation spectrum of a light–matter system
Authors: Opala A. , Furman M. , Król M. , Mirek R. , Tyszka K. , Seredyński B. , Pacuski W. , Szczytko J. , Matuszewski M. , Piętka B. 
Published: July 2023

In this work, we observe natural exceptional points in the excitation spectrum of an exciton–polariton system by optically tuning the light–matter interactions. The observed exceptional points do not require any spatial or polarization degrees of freedom and result solely from the transition from weak to strong light–matter coupling. It was demonstrated that they do not coincide with the threshold for photon lasing, confirming previous theoretical predictions [Phys. Rev. Lett. 122, 185301 (2019)PRLTAO0031-900710.1103/PhysRevLett.122.185301, Optica 7, 1015 (2020)OPTIC82334-253610.1364/OPTICA.397378]. Using a technique where a strong coherent laser pump induces up-converted excitations, we encircle the exceptional point in the parameter space of coupling strength and particle momentum. Our method of local optical control of light–matter coupling paves the way to the investigation of fundamental phenomena, including dissipative phase transitions and non-Hermitian topological states.
Influence of different primary surgical techniques on long-term intraocular pressure and medication in glaucoma after congenital cataract surgery
Authors: Strzalkowska Alicja , Strzalkowski Piotr , Stingl Julia V. , Pfeiffer Norbert , Schuster Alexander K. , Hoffmann Esther M. 
Published: July 2023

Purpose
To assess long-time results of primary surgical treatment in children with glaucoma after congenital cataract surgery.

Methods
A retrospective study of 37 eyes from 35 children with glaucoma after congenital cataract surgery, who underwent surgery between 2011 and 2021 at the Childhood Glaucoma Center, University Medical Center Mainz, Germany. Only children, who received a primary glaucoma surgery in our clinic within the given time (n = 25) and had at least one-year follow-up (n = 21), were included in the further analysis. The mean follow-up time was 40.4±35.1 months. The primary outcome was the mean reduction in IOP (in mmHg) from baseline to follow-up visits after the surgery, measured with Perkins tonometry.

Results
8 patients (38%) were treated with probe trabeculotomy (probe TO), 6 (29%) with 360° catheter-assisted trabeculotomy (360° TO) and 7 (33%) with cyclodestructive procedures. IOP was significantly reduced after probe TO and 360° TO after 2 years, from 26.9 mmHg to 17.4 mmHg (p<0.01) and 25.2 mmHg to 14.1 mmHg (p<0.02), respectively. There was no significant IOP reduction after cyclodestructive procedures after 2 years. Both, probe TO and 360° TO led descriptively to eye drops reduction after 2 years, from 2.0 to 0.7 and 3.2 to 1.1. The reduction was not significant.

Conclusions
In glaucoma after congenital cataract surgery, both trabeculotomy techniques, lead to good reduction of IOP after 2 years. There is a need for a prospective study with comparison to the use of glaucoma drainage implants.
Increased risk of pneumonia amongst residents living near goat farms in different livestock-dense regions in the Netherlands
Authors: Lotterman Aniek , Baliatsas Christos , de Rooij Myrna M. T. , Huss Anke , Jacobs José , Dückers Michel , Boender Gert Jan , McCarthy Catherine , Heederik Dick , Hagenaars Thomas J. , Yzermans C. Joris , Smit Lidwien A. M. 
Published: July 2023

Background
Previous studies, performed between 2009–2019, in the Netherlands observed an until now still unexplained increased risk for pneumonia among residents living close to goat farms. Since data were collected in the provinces Noord-Brabant and Limburg (NB-L), an area with relatively high air pollution levels and proximity to large industrial areas in Europe, the question remains whether the results are generalizable to other regions. In this study, a different region, covering the provinces Utrecht, Gelderland, and Overijssel (UGO) with a similar density of goat farms, was included to assess whether the association between goat farm proximity and pneumonia is consistently observed across the Netherlands.

Methods
Data for this study were derived from the Electronic Health Records (EHR) of 21 rural general practices (GPs) in UGO, for 2014–2017. Multi-level analyses were used to compare annual pneumonia prevalence between UGO and data derived from rural reference practices (‘control area’). Random-effects meta-analysis (per GP practice) and kernel analyses were performed to study associations of pneumonia with the distance between goat farms and patients’ home addresses.

Results
GP diagnoses of pneumonia occurred 40% more often in UGO compared to the control area. Meta-analysis showed an association at a distance of less than 500m (~70% more pneumonia compared to >500m) and 1000m (~20% more pneumonia compared to >1000m). The kernel-analysis for three of the four individual years showed an increased risk up to a distance of one or two kilometers (2–36% more pneumonia; 10–50 avoidable cases per 100,000 inhabitants per year).

Conclusions
The positive association between living in the proximity of goat farms and pneumonia in UGO is similar to the previously found association in NB-L. Therefore, we concluded that the observed associations are relevant for regions with goat farms in the entire country.