bluuebunny/crossref_metadata_2025_split huggingface dataset:
Accuracy of congenital anomaly coding in live birth children recorded in European health care databases, a EUROlinkCAT study
Authors: Bakker Marian K. , Loane Maria , Garne Ester , Ballardini Elisa , Cavero-Carbonell Clara , García Laura , Gissler Mika , Given Joanne , Heino Anna , Jamry-Dziurla Anna , Jordan Sue , Urhoj Stine Kjaer , Latos-Bieleńska Anna , Limb Elisabeth , Lutke Renee , Neville Amanda J. , Pierini Anna , Santoro Michele , Scanlon Ieuan , Tan Joachim , Wellesley Diana , de Walle Hermien E. K. , Morris Joan K. 
Published: February 2023

AbstractElectronic health care databases are increasingly being used to investigate the epidemiology of congenital anomalies (CAs) although there are concerns about their accuracy. The EUROlinkCAT project linked data from eleven EUROCAT registries to electronic hospital databases. The coding of CAs in electronic hospital databases was compared to the (gold standard) codes in the EUROCAT registries. For birth years 2010–2014 all linked live birth CA cases and all children identified in the hospital databases with a CA code were analysed. Registries calculated sensitivity and Positive Predictive Value (PPV) for 17 selected CAs. Pooled estimates for sensitivity and PPV were then calculated for each anomaly using random effects meta-analyses. Most registries linked more than 85% of their cases to hospital data. Gastroschisis, cleft lip with or without cleft palate and Down syndrome were recorded in hospital databases with high accuracy (sensitivity and PPV ≥ 85%). Hypoplastic left heart syndrome, spina bifida, Hirschsprung’s disease, omphalocele and cleft palate showed high sensitivity (≥ 85%), but low or heterogeneous PPV, indicating that hospital data was complete but may contain false positives. The remaining anomaly subgroups in our study, showed low or heterogeneous sensitivity and PPV, indicating that the information in the hospital database was incomplete and of variable validity. Electronic health care databases cannot replace CA registries, although they can be used as an additional ascertainment source for CA registries. CA registries are still the most appropriate data source to study the epidemiology of CAs.
Epistemic Functions of Replicability in Experimental Sciences: Defending the Orthodox View
Authors: Sikorski Michał , Andreoletti Mattia 
Published: February 2023

AbstractReplicability is widely regarded as one of the defining features of science and its pursuit is one of the main postulates of meta-research, a discipline emerging in response to the replicability crisis. At the same time, replicability is typically treated with caution by philosophers of science. In this paper, we reassess the value of replicability from an epistemic perspective. We defend the orthodox view, according to which replications are always epistemically useful, against the more prudent view that claims that it is useful in very limited circumstances. Additionally, we argue that we can learn more about the original experiment and the limits of the discovered effect from replications at different levels. We hold that replicability is a crucial feature of experimental results and scientists should continue to strive to secure it.
On cosmological low entropy after the Big Bang: universal expansion and nucleosynthesis
Authors: Sharpe Charlie F. , Barnes Luke A. , Lewis Geraint F. 
Published: February 2023

AbstractWe investigate the sensitivity of a universe’s nuclear entropy after Big Bang nucleosynthesis (BBN) to variations in both the baryon-to-photon ratio and the temporal evolution of cosmological expansion. Specifically, we construct counterfactual cosmologies to quantify the degree by which these two parameters must vary from those in our Universe before we observe a substantial change in the degree of fusion, and thus nuclear entropy, during BBN. We find that, while the post-BBN nuclear entropy is indeed linked to baryogenesis and the Universe’s expansion history, the requirement of leftover light elements does not place strong constraints on the properties of these two cosmological processes.
A study of Corchorus L. diversity in Egypt using high-throughput phenotyping platform (HTPP): an Egyptian gene bank example
Authors: Mahdy Ehab M. B. , Ahmad Hasan 
Published: February 2023

AbstractBiodiversity and identification facilitate a prioritization of determination basis for plant evolutionary, phytogeography, biodiversity and conservation of plant genetic resources. High-throughput phenotyping platforms (HTPP) provide more attractive for genotyping for biodiversity evaluation. Descriptor lists include 51 attributes applied on all growth-stages of 53 C. olitorius accessions plus C. capsularis, C. trilocularis, C. tridens, and C. depressus. Three main groups were split. Variance decomposition was estimated within class of 68.87% and between classes of 31.13%. Major distance recorded 18.41 between class 1 (wild taxa only) and class three (18 accessions of C. olitorius). In contrast, the minor distance scored 8.3 between class 2 (35 accessions) and class 3 (18 accessions). Wild taxa with their rarity distribution and habitats prioritize highly conservation due to the association of evolutionary role and importance of genetic improvement. Conservation strategies applied to PGR prioritization are influenced by the distribution frequency and habitat specificity. The results are useful information on genetic diversity at the Egyptian Gene Bank, which could be used for C. olitorius genetic improvement programs and sustainable utilization.
No transport? No worries! Cardiac telerehabilitation is a feasible and effective alternative to centre-based programs
Authors: Hwang Rita , Gane Elise M. , Morris Norman R. 
Published: February 2023

Abstract
Given the under-utilisation of cardiac rehabilitation despite its benefits, there has been a shift towards alternative delivery models. The recent coronavirus disease 2019 (COVID-19) pandemic has accelerated this shift, leading to a growing interest in home-based cardiac rehabilitation including telerehabilitation. There is increasing evidence to support cardiac telerehabilitation, with studies generally demonstrating comparable outcomes and potential cost-benefits. This review aims to provide a synopsis of the current evidence on home-based cardiac rehabilitation with a focus on telerehabilitation and practical considerations.
Individual repeatability in the timing of river entry indicates the strong influence of photoperiod in the spawning migrations of iteroparous twaite shad Alosa fallax
Authors: Yeldham Mark I. A. , Britton J. Robert , Crundwell Charles , Davies Peter , Dodd Jamie R. , Nunn Andrew D. , Velterop Randolph , Bolland Jonathan D. 
Published: February 2023

AbstractThe timing of entry into freshwater by mature anadromous fishes is an important component of their migration phenology. In iteroparous anadromous species, identifying the migration cues that influence the timing of entry into freshwater, and annual variability in these timings, is important in assessing the extent of individual repeatability. Here, passive acoustic telemetry tracked 71 twaite shad Alosa fallax (‘shad’) returning to the River Severn’s upper estuary over successive spawning seasons, providing individual information on river entry timing and the associated migration cues. The timing of shad returning to the river (defined as their first detection on an acoustic receiver in the upper estuary) was consistent between years and strongly predicted by photoperiod (as increasing day length), whereas water temperatures and flow rates were weak predictors and highly variable between years. Timings of river entry of individual shad were also consistent across consecutive spawning migrations, indicating high individual repeatability. The application of acoustic telemetry in this study thus revealed high repeatability in the timing of annual spawning migrations, which were cued mainly by increasing day length and that, being seasonally predictable, should ensure entry into freshwater with sufficient time to arrive in spawning areas when in-river environmental conditions are favourable.
Enhancing ERP Responsiveness Through Big Data Technologies: An Empirical Investigation
Authors: Bandara Florie , Jayawickrama Uchitha , Subasinghage Maduka , Olan Femi , Alamoudi Hawazen , Alharthi Majed 
Published: February 2023

AbstractOrganizations are integrating big data technologies with Enterprise Resource Planning (ERP) systems with an aim to enhance ERP responsiveness (i.e., the ability of the ERP systems to react towards the large volumes of data). Yet, organizations are struggling to manage the integration between the ERP systems and big data technologies, leading to lack of ERP responsiveness. For example, it is difficult to manage large volumes of data collected through big data technologies and to identify and transform the collected data by filtering, aggregating and inferencing through the ERP systems. Building on this motivation, this research examined the factors leading to ERP responsiveness with a focus on big data technologies. The conceptual model which was developed through a systematic literature review was tested using Structural equation modelling (SEM) performed on the survey data collected from 110 industry experts. Our results suggested 12 factors (e.g., big data management and data contextualization) and their relationships which impact on ERP responsiveness. An understanding of the factors which impact on ERP responsiveness contributes to the literature on ERP and big data management as well as offers significant practical implications for ERP and big data management practice.
Heather (Calluna vulgaris) supports spider diversity of oligotrophic peat bogs
Authors: Urák István , Gallé-Szpisjak Nikolett , Szigyártó Irma-Lídia , Zsigmond Andreea-Rebeka , Gallé Róbert 
Published: February 2023

AbstractThe heterogeneity of microhabitats is an important driver of biodiversity. Therefore, conserving habitat heterogeneity at multiple spatial scales is essential to biodiversity conservation. This study investigates the effect and the conservation value of micromosaic heterogeneity provided by the heather (Calluna vulgaris) patches in an Eastern-European peat bog on the spider communities. We found that the heather patches strongly affect spiders; the species richness and abundance were higher in heather than in open bogs. Heather shrubs form a separate special microhabitat, which differs in structure, microclimate and litter quality, and has a significant positive effect on diversity of spiders. Furthermore, we collected smaller spiders and more web builders in heather sites than in control sites, presumably due to the different microhabitat structures and prey availability. However, habitat type did not affect the vertical microhabitat preference of spiders. The species composition of spider communities differed between the two microhabitat types. We identified seven significant indicator species in heather shrubs, whereas three species were significant indicators of control sites. The species richness and the presence of rare and endangered peat bog specialist spider species in heather patches highlight the high conservation value of peat bogs.
A Cohort Study on Deficiency of ADA2 from China
Authors: Li Guo-min , Han Xu , Wu Ye , Wang Wei , Tang Hong-xia , Lu Mei-ping , Tang Xue-mei , Lin Yi , Deng Fan , Yang Jun , Wang Xin-ning , Liu Cong-cong , Zheng Wen-jie , Wu Bing-bing , Zhou Fang , Luo Hong , Zhang Liang , Liu Hai-mei , Guan Wan-zhen , Wang Shi-hao , Tao Pan-feng , Jin Tai-jie , Fang Ran , Wu Yuan , Zhang Jie , Zhang Yao , Zhang Tian-nan , Yin Wei , Guo Li , Tang Wen-jing , Chang Hong , Zhang Qiu-ye , Li Xiao-zhong , Li Jian-guo , Zhou Zhi-xuan , Yang Si-rui , Yang Kang-kang , Xu Hong , Song Hong-mei , Deuitch Natalie T. , Lee Pui Y. , Zhou Qing , Sun Li 
Published: February 2023

Abstract

Purpose
Deficiency of adenosine deaminase 2 (DADA2), an autosomal recessive autoinflammatory disorder caused by biallelic loss-of-function variants in adenosine deaminase 2 (ADA2), has not been systemically investigated in Chinese population yet. We aim to further characterize DADA2 cases in China.

Methods
A retrospective analysis of patients with DADA2 identified through whole exome sequencing (WES) at seventeen rheumatology centers across China was conducted. Clinical characteristics, laboratory findings, genotype, and treatment response were analyzed.

Results
Thirty patients with DADA2 were enrolled between January 2015 and December 2021. Adenosine deaminase 2 enzymatic activity was low in all tested cases to confirm pathogenicity. Median age of disease presentation was 4.3 years and the median age at diagnosis was 7.8 years. All but one patient presented during childhood and two subjects died from complications of their disease. The patients most commonly presented with systemic inflammation (92.9%), vasculitis (86.7%), and hypogammaglobinemia (73.3%) while one patient presented with bone marrow failure (BMF) with variable cytopenia. Twenty-three (76.7%) patients were treated with TNF inhibitors (TNFi), while two (6.7%) underwent hematopoietic stem cell transplantation (HSCT). They all achieved clinical remission. A total of thirty-nine ADA2 causative variants were identified, six of which were novel.

Conclusion
To establish early diagnosis and improve clinical outcomes, genetic screening and/or testing of ADA2 enzymatic activity should be performed in patients with suspected clinical features. TNFi is considered as first line treatment for those with vascular phenotypes. HSCT may be beneficial for those with hematological disease or in those who are refractory to TNFi.
Contrast-enhanced transcranial doppler versus contrast transthoracic echocardiography for right-to-left shunt diagnosis
Authors: Tian Li , Zhang Min , Nie Hongjun , Zhang Guanling , Luo Xiaoyan , Yuan Huaiyun 
Published: February 2023

AbstractRLS can be diagnosed using US, CT angiography, and right heart catheterization. However, most reliable diagnostic modality remains undetermined. c-TCD was more sensitive than c-TTE in the diagnosis of RLS. This was true especially for the detection of provoked shunts or mild shunts. c-TCD can be used as the preferred screening method for RLS.
Motive Satisfaction Among Patients with Chronic Primary Pain: A Replication
Authors: Scheidegger Alina , Goméz Penedo Juan Martín , Blättler Larissa Tatjana , Aybek Selma , Bischoff Nina , grosse Holtforth Martin 
Published: February 2023

AbstractWe set out to replicate findings of significant (a) reductions in pain, psychological distress, and motivational incongruence (i.e., insufficient motive satisfaction) after interdisciplinary multimodal pain treatment and (b) associations between reductions in motivational incongruence (i.e., improved motive satisfaction) and decreases in psychological distress (Vincent et al., Journal of Clinical Psychology in Medical Settings 28:331–343, 2021). 475 Patients with chronic primary pain completed standardized self-reported questionnaires assessing motivational incongruence, psychological distress, pain intensity, and pain interference at intake and discharge from a tertiary psychosomatic university clinic. We used hierarchical linear models to analyze motivational incongruence’s effects on psychological distress. We partially replicated Vincent et al.’s findings. Significant reductions in pain, psychological distress, and motivational incongruence after treatment were found. Reductions in motivational incongruence were associated with reductions in psychological distress. Similarly, a better motive satisfaction mediated the relationship between pain interference and psychological distress. Our findings show that reducing motivational incongruence may be a key component of treating chronic primary pain; we recommend to assess and target motivational incongruence to improve interdisciplinary multimodal pain treatment.
Post-heating Fluorescence-based Alteration and Adulteration Detection of Extra Virgin Olive Oil
Authors: Hamdy Omnia , Mohammed Haitham S. 
Published: February 2023

AbstractOlive oils are more expensive compared with other vegetable oils. Therefore, adulterating such expensive oil is prevalent. The traditional methods for olive oil adulteration detection are complex and require pre-analysis sample preparation. Therefore, simple and precise alternative techniques are required. In the present study, the Laser-induced fluorescence (LIF) technique was implemented for detecting alteration and adulteration of olive oil mixed with sunflower or corn oil based on the post-heating emission characteristics. Diode-pumped solid-state laser (DPSS, λ = 405 nm) was employed for excitation and the fluorescence emission was detected via an optical fiber connected to a compact spectrometer. The obtained results revealed alterations in the recorded chlorophyll peak intensity due to olive oil heating and adulteration. The correlation of the experimental measurements was evaluated via partial least-squares regression (PLSR) with an R-squared value of 0.95. Moreover, the system performance was evaluated using receiver operating characteristics (ROC) with a maximum sensitivity of 93%.
Parallels in Practice: Applying Principles of Research Integrity and Ethics in Domestic Violence Fatality Review (DVFR)
Authors: Cook Elizabeth A. , Rowlands James , Bracewell Kelly , Jones Cassandra , Boughton Grace 
Published: February 2023

Abstract

Purpose
Within the context of the big data society, new systems of data collection on domestic violence and abuse (DVA) have emerged. One such system is Domestic Violence Fatality Review (DVFR) which captures the various dimensions of gender, violence, and abuse required to form an evidence base for prevention. However, to date, there has been limited dialogue between practitioners and researchers about the ‘doing’ of DVFRs.

Method
As DVFR systems vary by jurisdiction, we conducted a case study of Domestic Homicide Reviews (DHRs) in England and Wales. Applying the Research Integrity Framework (RIF) developed by the four Women’s Aid Federations in the United Kingdom (UK), this article examines both the practice of DHR and how it is utilised as data in research.

Results
Informed by our situated perspectives as researchers and/or practitioners working in the field, our analysis demonstrates how undertaking DHR as a practitioner parallels collecting, accessing, and analysing data from DHRs as a researcher. Guiding principles are identified to help practitioners and researchers navigate the parallel challenges they confront and, critically, inform dialogue between practice and research.

Conclusions
Implications for both professional practice and research are presented. To increase transparency and confidence, we argue that more attention should be afforded to the methodological and ethical issues inherent in both the practice of DHRs, and their utilisation as a source of data in research. While DHRs have differences to DVFRs in other jurisdictions, these findings also have implications for these other systems which will also be discussed.
Perceived earthquake risk in housing purchases
Authors: Shi Song , Naylor Michael 
Published: February 2023

AbstractThis paper investigates the impact of an earthquake on households' perception of the seismic risks associated with residential locations—and, consequently, the impact of this change in perceptions on real estate prices—by performing revealed preference analysis on a unique data set of house prices and damage claims after the 2010/2011 Canterbury earthquake in New Zealand. We show that both informational and heuristic obstacles could have caused households to underestimate location earthquake risk before the quake and overreact to it after the quake. Our findings highlight the importance of quake-related information for seismic risk management and are robust to households’ risk preferences in neighborhood propensity score matching.
Valine Treatment Enhances Antimicrobial Component Production in Mammary Epithelial Cells and the Milk of Lactating Goats Without Influencing the Tight Junction Barrier
Authors: Tsugami Yusaku , Nii Takahiro , Isobe Naoki 
Published: February 2023

AbstractThe production of antimicrobial components and the formation of less-permeable tight junctions (TJs) are important in the defense system of lactating mammary glands and for safe dairy production. Valine is a branched-chain amino acid that is actively consumed in the mammary glands and promotes the production of major milk components like β-casein; additionally, branched-chain amino acids stimulate antimicrobial component production in the intestines. Therefore, we hypothesized that valine strengthens the mammary gland defense system without influencing milk production. We investigated the effects of valine in vitro using cultured mammary epithelial cells (MECs) and in vivo using the mammary glands of lactating Tokara goats. Valine treatment at 4 mM increased the secretion of S100A7 and lactoferrin as well as the intracellular concentration of β-defensin 1 and cathelicidin 7 in cultured MECs. In addition, an intravenous injection of valine increased S100A7 levels in the milk of Tokara goats without influencing milk yield and milk components (i.e., fat, protein, lactose, and solids). In contrast, valine treatment did not affect TJ barrier function either in vitro or in vivo. These findings indicate that valine enhances antimicrobial component production without influencing milk production and TJ barrier function in lactating mammary glands; thus, valine contributes to safe dairy production.
Rank ectopic expression in the presence of Neu and PyMT oncogenes alters mammary epithelial cell populations and their tumorigenic potential
Authors: Cordero Alex , Santamaría Patricia G. , González-Suárez Eva 
Published: February 2023

AbstractDetermination of the mammary epithelial cell that serves as the cell of origin for breast cancer is key to understand tumor heterogeneity and clinical management. In this study, we aimed to decipher whether Rank expression in the presence of PyMT and Neu oncogenes might affect the cell of origin of mammary gland tumors. We observed that Rank expression in PyMT+/− and Neu+/− mammary glands alters the basal and luminal mammary cell populations already in preneoplasic tissue, which may interfere with the tumor cell of origin restricting their tumorigenesis ability upon transplantation assays. In spite of this, Rank expression eventually promotes tumor aggressiveness once tumorigenesis is established.
Propagation and variation of material characteristics during the uranium ore concentrate production at Dolní Rožinka, Czech Republic
Authors: Varga Zsolt , Nicholl Adrian , Wallenius Maria , Mayer Klaus , Mock Todd 
Published: February 2023

AbstractIn the framework of the European Commission Support Programme to the International Atomic Energy Agency (EC SP task A1753) 20 samples were obtained from the Dolní Rožínka (DIAMO, Czech Republic) uranium milling facility. The sampling procedure followed stepwise the uranium production and purification from the U ore to uranium ore concentrate (yellow cake) end-product. Elemental concentrations, rare-earth elemental pattern, anion concentrations, morphology and isotope abundance ratios of S, Sr, Pb and U were measured at each sampling stage. The purpose of the measurements was to investigate the applicability of various material characteristics for authentication, propagation and variation of these parameters, and to identify the relevant signatures for nuclear forensics and safeguards during the uranium production.