bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prescription Practices and Outcome Analysis of PICU Patients at a Newly Established Tertiary Care Hospital—A Retrospective Study
Authors: Chalissery Leo Francis , Eerike Madhavi , Samprati Madhusudan , Reddy Mounika , Elango Chandru , Ramanna Kalpana Mali , Gupta Jhilmil 
Published: July 2023

AbstractPrescription analysis studies play a crucial role in monitoring prescription patterns and establishing guidelines for effective drug delivery and health care management. Given the physiological differences between the pediatric and adult populations, it is essential to analyze the prescription records specifically for pediatric patients, considering their unique diseases, drugs, and dosages. The objectives of this study were to analyze the prescribing patterns of drugs, rationality, outcomes, and antimicrobial use and drugs from National List of Essential Medicines (NLEM) in pediatric intensive care unit (PICU) patients. A retrospective study design was employed, and data were collected from medical records, including demographic information, diagnoses, drug details, and treatment outcomes of PICU patients. The collected data were then analyzed according to the World Health Organization (WHO) indicators for rational drug use, WHO Access, Watch, and Reserve (AWaRe) guidelines for antimicrobial use, and the proportion of essential drugs prescribed. Descriptive statistics was used to express the data in this study. A total of 184 patient records were analyzed, with 57.6% were males. On average, 4.5 drugs were prescribed per prescription, with injections and syrups comprising nearly 28% each. Approximately 71.5% of prescriptions contained generic drug names. Furthermore, 49% of the prescribed drugs were listed in the NLEM. Antibiotics were present in 50% of the prescriptions, with 50% of them falling under the WHO AWaRe Watch category and 31% in Access category. Majority of the drugs being prescribed in the PICU were with generic names, and less than half the prescriptions contained antibiotics. Watch class of antibiotics was most commonly prescribed.
Gramsci’s ‘Southern Question’ and Egypt’s authoritarian retrenchment: subalternity and the disruption of activist agency
Authors: Gervasio Gennaro , Teti Andrea 
Published: July 2023

ABSTRACT
Explanations of the authoritarian retrenchment after Egypt’s 2011 Revolution invoke either the regime’s repressive advantage over ‘leaderless’ mobilisation and civic activists, or insufficient preparations and radicalism on the part of opposition groups. Both explanations are unsatisfactory. First, because despite being ‘reformist’, opposition groups’ demands were perceived as radical challenges to regimes before, during and after the uprisings. Second, because appeals to regimes’ coercive capacity contradict explanations of opponents’ rise to prominence before the uprisings: if activists eroded Egypt’s authoritarian regime before 2011, what made them unable to continue doing so afterwards? Conversely, if activists’ agency was effective before 2011 despite gross imbalances in coercive capacity, then those imbalances alone cannot explain activists’ post-revolutionary decline. In short, if activists’ agency cannot be denied before Egypt’s ‘eighteen days’, it must be accounted for in their aftermath. To do this, the authors draw on Gramsci’s original texts and Italian-language scholarship to develop his neglected notion of disgregazione.
Reactant enrichment in hollow void of Pt NPs@MnOx nanoreactors for boosting hydrogenation performance
Authors: Ma Yanfu , Wang Liwei , Zhao Wantong , Liu Tianyi , Li Haitao , Luo Wenhao , Jiang Qike , Liu Wei , Yang Qihua , Huang Jun , Zhang Riguang , Liu Jian , Lu G Q Max , Li Can 
Published: July 2023

ABSTRACT
In confined mesoscopic spaces, the unraveling of a catalytic mechanism with complex mass transfer and adsorption processes such as reactant enrichment is a great challenge. In this study, a hollow nanoarchitecture of MnOx-encapsulated Pt nanoparticles was designed as a nanoreactor to investigate the reactant enrichment in a mesoscopic hollow void. By employing advanced characterization techniques, we found that the reactant-enrichment behavior is derived from directional diffusion of the reactant driven through the local concentration gradient and this increased the amount of reactant. Combining experimental results with density functional theory calculations, the superior cinnamyl alcohol (COL) selectivity originates from the selective adsorption of cinnamaldehyde (CAL) and the rapid formation and desorption of COL in the MnOx shell. The superb performance of 95% CAL conversion and 95% COL selectivity is obtained at only 0.5 MPa H2 and 40 min. Our findings showcase that a rationally designed nanoreactor could boost catalytic performance in chemoselective hydrogenation, which can be of great aid and potential in various application scenarios.
Viral Determinants of Acute COVID-19 Symptoms in a Nonhospitalized Adult Population in the Pre-Omicron Era
Authors: Goldberg Sarah A , Lu Scott , Garcia-Knight Miguel , Davidson Michelle C , Tassetto Michel , Anglin Khamal , Pineda-Ramirez Jesus , Chen Jessica Y , Rugart Paulina R , Mathur Sujata , Forman Carrie A , Donohue Kevin C , Abedi Glen R , Saydah Sharon , Briggs-Hagen Melissa , Midgley Claire M , Andino Raul , Peluso Michael J , Glidden David V , Martin Jeffrey N , Kelly J Daniel 
Published: July 2023

Abstract

Background
The influence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA level and presence of infectious virus on symptom occurrence is poorly understood, particularly among nonhospitalized individuals.

Methods
The study included 85 nonhospitalized, symptomatic adults, who were enrolled from September 2020 to November 2021. Data from a longitudinal cohort studied over 28 days was used to analyze the association of individual symptoms with SARS-CoV-2 viral RNA load, or the presence or level of infectious (culturable) virus. Presence of infectious virus and viral RNA load were assessed daily, depending on specimen availability, and amount of infectious virus was assessed on the day of maximum RNA load. Participants were surveyed for the start and end dates of 31 symptoms at enrollment and at days 9, 14, 21, and 28; daily symptom presence was determined analytically. We describe symptoms and investigate their possible association with viral determinants through a series of single or pooled (multiple days across acute period) cross-sectional analyses.

Results
There was an association between viral RNA load and the same-day presence of many individual symptoms. Additionally, individuals with infectious virus were more than three times as likely to have a concurrent fever than individuals without infectious virus, and more than two times as likely to have concurrent myalgia, chills, headache, or sore throat.

Conclusions
We found evidence to support the association of viral RNA load and infectious virus on some, but not all symptoms. Fever was most strongly associated with the presence of infectious virus; this may support the potential for symptom-based isolation guidance for COVID-19.
Medium chain length polyhydroxyalkanoates as potential matrix materials for peripheral nerve regeneration
Authors: Nigmatullin Rinat , Taylor Caroline S , Basnett Pooja , Lukasiewicz Barbara , Paxinou Alexandra , Lizarraga-Valderrama Lorena R , Haycock John W , Roy Ipsita 
Published: July 2023

Abstract
Polyhydroxyalkanoates are natural, biodegradable, thermoplastic and sustainable polymers with a huge potential in fabrication of bioresorbable implantable devices for tissue engineering. We describe a comparative evaluation of three medium chain length polyhydroxyalkanoates (mcl-PHAs), namely poly(3-hydroxyoctanoate), poly(3-hydroxyoctanoate-co-3-hydoxydecanoate) and poly(3-hydroxyoctanoate-co-3-hydroxydecanoate-co-3-hydroxydodecanoate), one short chain length polyhydroxyalkanoate, poly(3-hydroxybutyrate), P(3HB) and synthetic aliphatic polyesters (polycaprolactone and polylactide) with a specific focus on nerve regeneration, due to mechanical properties of mcl-PHAs closely matching nerve tissues. In vitro biological studies with NG108-15 neuronal cell and primary Schwann cells did not show a cytotoxic effect of the materials on both cell types. All mcl-PHAs supported cell adhesion and viability. Among the three mcl-PHAs, P(3HO-co-3HD) exhibited superior properties with regards to numbers of cells adhered and viable cells for both cell types, number of neurite extensions from NG108-15 cells, average length of neurite extensions and Schwann cells. Although, similar characteristics were observed for flat P(3HB) surfaces, high rigidity of this biomaterial, and FDA-approved polymers such as PLLA, limits their applications in peripheral nerve regeneration. Therefore, we have designed, synthesized and evaluated these materials for nerve tissue engineering and regenerative medicine, the interaction of mcl-PHAs with neuronal and Schwann cells, identifying mcl-PHAs as excellent materials to enhance nerve regeneration and potentially their clinical application in peripheral nerve repair.
THE ALARMIN EFFECT OF HMGB1/RIP3 ON TRANSFUSION-RELATED ACUTE LUNG INJURY VIA TLR4/NF-ΚB OR MAPK PATHWAY
Authors: Liu Shuangchun , Lin Ronghai , Zhang Xianchao , Lv Yinyi , Zhu Jie , Chen Guang , Du Yunting 
Published: July 2023

ABSTRACT
Nonantibody-mediated transfusion-related acute lung injury (TRALI) may account for up to 25% of TRALI cases. This indicates the need for further research to understand the pathophysiological mechanisms involved beyond antibody mediation fully. During this research, a TRALI rat model was developed using the trauma-blood loss-massive transfusion method. The severity of pulmonary edema was checked via measurement of lung histopathological changes and the amount of Evans blue dye fluid and bronchoalveolar lavage fluid protein leakage. In addition, potential mechanisms of pathophysiological pathways and inflammation cascades were investigated in TRALI rats in vivo. The findings indicated that TRALI increased inflammatory cytokines and triggered elevated levels of high-mobility group box 1 (HMGB1)/receptor-interacting protein kinase 3 (RIP3), apoptosis protein, and mRNAs in the TM (TRALI model) group as opposed to the normal control. Furthermore, TRALI activated the toll-like receptor 4/nuclear factor kappa B and mitogen-activated protein kinase signaling pathways, which partially regulated the inflammatory response in the TRALI rats. A significant increase was observed in the inflammatory mediators HMGB1 and RIP3 during the early stages of TRALI, suggesting that these mediators could be used as diagnostic markers for TRALI. In addition, HMGB1 and RIP3 promoted the inflammatory response by stimulating the toll-like receptor 44/nuclear factor kappa B and mitogen-activated protein kinase signaling pathways in the lung tissue of rats. Identifying efficient agents from inflammatory mediators such as alarmin can be an innovative scheme for diagnosing and preventing TRALI. These findings give HMGB1 and RIP3 a strong theoretical and experimental foundation for clinical use.
Mu-opioid receptor-dependent changes in social reward across adolescence in mice
Authors: Harda Zofia , Klimczak Marta , Misiołek Klaudia , Chrószcz Magdalena , Szumiec Łukasz , Kaczmarczyk-Jarosz Maria , Ryguła Rafał , Ziółkowska Barbara , Parkitna Jan Rodriguez 
Published: July 2023

AbstractIn humans, adolescence is a time of dynamic behavioral changes, including a transient decrease in affect associated with being among family members. Here, we found that the reward value of interactions with siblings in adolescent male mice followed a similar course to that in humans: high in preadolescence, a decrease in mid-adolescence and a return to the initial level in late adolescence, as observed in the social conditioned place preference task. The observed change was specific to social interaction, as the rewarding effect of cocaine was actually increased during mid-adolescence. Strikingly, treatment with a selective mu-opioid receptor antagonist, cyprodime, increased socially conditioned place preference in mid-adolescent mice, but not in older animals. Taken together, these data show similarities between mice and humans in developmental changes in sensitivity to the rewarding effects of interactions with familiar kin and demonstrate the involvement of endogenous opioid signaling in shaping adolescent social behavior.
Investigating the effect of POPC-POPG Lipid Bilayer Composition on PAP248-286 Binding using CG Molecular Dynamics Simulations
Authors: Agrawal Nikhil , Parisini Emilio 
Published: July 2023

AbstractPAP248-286 is a fusogenic peptide derived from prostatic acid phosphatase, commonly found in human semen, and is known to mediate HIV fusion with cell membranes. In this study, we performed 120 independent coarse-grained molecular dynamics simulations to investigate the spontaneous binding of PAP248-286 monomers, considering both charged and neutral histidine (His) residues, to membrane bilayers composed of different lipid compositions: 100% POPC, 70% POPC-30% POPG, and 50% POPC-50% POPG. Our simulations revealed that PAP248-286 displayed spontaneous binding to the membrane, with increased binding observed in the presence of anionic lipid POPG. Specifically, in systems containing 30% and 50% POPG lipids, monomer residues, particularly in the systems containing charged histidine (His) residues, exhibited prolonged binding with the membrane. Furthermore, our simulations indicated that PAP248-286 adopted a parallel orientation with the membrane, exposing its positively charged residues to the lipid bilayer. Interestingly, systems containing charged His residues showed higher lipid occupancy around the peptide. These findings are consistent with previous experimental data, suggesting that PAP248-286 binding is enhanced in membranes with charged His residues, resembling the conditions found in the acidic vaginal pH environment. The results of our study provide further insights into the molecular mechanisms underlying the membrane binding of PAP248-286, contributing to our understanding of its potential role in HIV fusion and infection.
Unlocking agility: Trapped in the antagonism between co-innovation in digital platforms, business analytics capability and external pressure for AI adoption?
Authors: Arias-Pérez José , Chacón-Henao Juliana , López-Zapata Esteban 
Published: July 2023

PurposeDigital technology is increasingly important in enhancing organizational agility (OA). Institutional theory and resource-based view were harmonized to analyze firms' adoption of digital technologies. However, previous studies on OA have revealed that external pressures imply the imposition of barriers or technological standards that ultimately restrict OA. This study employs this double theoretical lens to investigate the mediation role of business analytics capability (BAC) in the relationship between co-innovation (CO), i.e. open innovation in digital platforms, and OA, as well as the negative moderating effect of external pressure for artificial intelligence adoption (EPAIA) on this mediation.Design/methodology/approachStructural equation modeling was used to test the moderated mediation with survey data from 229 firms.FindingsThe main result indicates that 72% of OA variance is explained by the effect of CO that is transmitted by the mediator (BAC). However, contrary to the authors' expectations, EPAIA only has a positive moderating effect along the path between BAC and OA.Originality/valueThis work contradicts the prevalent notion of the negative consequences of external pressures for artificial intelligence adoption. Specifically, this study's findings refute the notion that institutional pressures are the source of technical problems that disrupt CO and BAC integration and reduce OA. In contrast, the unexpectedly positive effect of EPAIA may indicate that this type of external pressure can be viewed as a significant sign and an opportunity for the company to adopt the industry's most advanced and effective digital transformation practices.
Igniting innovative: how transformational leadership and job crafting empower innovative among Iraqi nurses in public hospitals
Authors: Alwali Joather 
Published: July 2023

Purpose
The purpose of this research paper is to study the effect of transformational leadership (TL) and job crafting (JC) on nurses’ innovative work behaviors (IWB) while accounting for the mediating effect of psychological empowerment (PsyEmp).

Design/methodology/approach
To test the developed hypotheses quantitatively, two statistical methods were used: structural equation modeling via partial least squares and bootstrapping estimation. The survey elicited responses from 270 nurses, but after data screening, only 168 were used. Confirmatory factor analysis was used to establish the distinctness of the variables used in this study.

Findings
Findings indicate that there are a positive influence of both TL and JC on PsyEmp. Additionally, the findings show a beneficial effect of PsyEmp as a mediator between TL, JC and IWB.

Originality/value
This study adds to the body of knowledge by demonstrating the effects of nurse TL and JC on nurses’ PsyEmp and IWB. In addition to the role of PsyEmp as a partial mediator in the relationship between TL, JC and IWB. The research novelty resides in the fact that none of these links has before been studied in the context of Iraq.
An integrated approach to explore the barriers to lean manufacturing in the context of the COVID-19 pandemic: implications for sustainability
Authors: Salman Sheak , Ahmed Tazim , Taqi Hasin Md. Muhtasim , Frederico Guilherme F. , Dip Amit Sarker , Ali Syed Mithun 
Published: July 2023

PurposeThe apparel industry of Bangladesh is rethinking lean manufacturing (LM) deployment because of the challenges imposed by the COVID-19 pandemic. Due to COVID-19, LM implementation in the apparel industry has become more difficult. Thus, the purpose of this study is to explore the barriers to implementing LM practices in the apparel industry of Bangladesh in the context of COVID-19 pandemic.Design/methodology/approachFor evaluating the barriers, an integrated framework that combines the Delphi method and fuzzy total interpretive structural modeling (TISM) has been designed. The application of fuzzy TISM has resulted in a structured hierarchical relationship model of the barriers with driving and driven power.FindingsThe findings reveal that “lack of synchronization of lean planning with strategic planning”, “lack of proper understanding of lean concept” and “low priority from the top management” are the three top most important barriers of LM implementation in apparel industry.Practical implicationsThese findings will help the apparel industry to formulate strategy for implementing the LM practices successfully. The proposed model is expected to contribute to the sustainable development goals (SDGs) such as Responsible Consumption and Production (SDG 12); Decent Work and Economic Growth (SDG 8); Industry, Innovation and Infrastructure (SDG 9) via resilient strategies.Originality/valueThis study is one of few initial efforts to investigate LM implementation barriers during the COVID-19 epidemic in a real-world setting.
The dance of dependence: a macro-perspective on financial instability and its complex influence on the Euro-American green markets
Authors: Gaies Brahim , Chaâbane Najeh 
Published: July 2023

PurposeThis study adopts a new macro-perspective to explore the complex and dynamic links between financial instability and the Euro-American green equity market. Its primary focus and novelty is to shed light on the non-linear and asymmetric characteristics of dependence, causality, and contagion within various time and frequency domains. Specifically, the authors scrutinize how financial instability in the U.S. and EU interacts with their respective green stock markets, while also examining the cross-impact on each other's green equity markets. The analysis is carried out over short-, medium- and long-term horizons and under different market conditions, ranging from bearish and normal to bullish.Design/methodology/approachThis study breaks new ground by employing a model-free and non-parametric approach to examine the relationship between the instability of the global financial system and the green equity market performance in the U.S. and EU. This study's methodology offers new insights into the time- and frequency-varying relationship, using wavelet coherence supplemented with quantile causality and quantile-on-quantile regression analyses. This advanced approach unveils non-linear and asymmetric causal links and characterizes their signs, effectively distinguishing between bearish, normal, and bullish market conditions, as well as short-, medium- and long-term horizons.FindingsThis study's findings reveal that financial instability has a strong negative impact on the green stock market over the medium to long term, in bullish market conditions and in times of economic and extra-economic turbulence. This implies that green stocks cannot be an effective hedge against systemic financial risk during periods of turbulence and euphoria. Moreover, the authors demonstrate that U.S. financial instability not only affects the U.S. green equity market, but also has significant spillover effects on the EU market and vice versa, indicating the existence of a Euro-American contagion mechanism. Interestingly, this study's results also reveal a positive correlation between financial instability and green equity market performance under normal market conditions, suggesting a possible feedback loop effect.Originality/valueThis study represents pioneering work in exploring the non-linear and asymmetric connections between financial instability and the Euro-American stock markets. Notably, it discerns how these interactions vary over the short, medium, and long term and under different market conditions, including bearish, normal, and bullish states. Understanding these characteristics is instrumental in shaping effective policies to achieve the Sustainable Development Goals (SDGs), including access to clean, affordable energy (SDG 7), and to preserve the stability of the international financial system.
Environmental certifications and customer satisfaction: evidence from kindergartens
Authors: Utgård Jakob 
Published: July 2023

Purpose The purpose of this paper is to study whether environmental certifications increase customer satisfaction in kindergartens, and whether this relationship is influenced by kindergarten size or ownership type.Design/methodology/approach Data from a parental satisfaction survey in Norwegian kindergartens is combined with data on environmental certifications (n = 2033–3270 kindergartens over 7 years, approximately 11% certified). Regression models with extensive controls are used to test the relationships.Findings The main pooled cross-sectional regression and all panel data regression models show no significant relationships between environmental certification and customer satisfaction. Organizational size or ownership type (for-profit/non-profit) does not moderate the relationship.Research limitations/implications Environmental certifications have little or no impact on customer satisfaction in this sample of kindergartens.Originality/value The study contributes by examining the effects of environmental certifications on customer satisfaction in kindergartens, a little studied topic and a sector, and by using a large sample, secondary data and panel data methods, avoiding some limitations in earlier research.