bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hydrodynamic and non-hydrodynamic excitations in kinetic theory — a numerical analysis in scalar field theory
Authors: Ochsenfeld Stephan , Schlichting Sören 
Published: September 2023

Abstract
Viscous hydrodynamics serves as a successful mesoscopic description of the Quark-Gluon Plasma produced in relativistic heavy-ion collisions. In order to investigate, how such an effective description emerges from the underlying microscopic dynamics we calculate the hydrodynamic and non-hydrodynamic modes of linear response in the sound channel from a first-principle calculation in kinetic theory. We do this with a new approach wherein we discretize the collision kernel to directly calculate eigenvalues and eigenmodes of the evolution operator. This allows us to study the Green’s functions at any point in the complex frequency space. Our study focuses on scalar theory with quartic interaction and we find that the analytic structure of Green’s functions in the complex plane is far more complicated than just poles or cuts which is a first step towards an equivalent study in QCD kinetic theory.
Galectin-9 interacts with Vamp-3 to regulate cytokine secretion in dendritic cells
Authors: Santalla Méndez Rui , Rodgers Furones Andrea , Classens René , Fedorova Kristina , Haverdil Manon , Canela Capdevila Marta , van Duffelen Anne , Spruijt Cornelia G. , Vermeulen Michiel , ter Beest Martin , van Spriel Annemiek B. , Querol Cano Laia 
Published: September 2023

AbstractIntracellular vesicle transport is essential for cellular homeostasis and is partially mediated by SNARE proteins. Endosomal trafficking to the plasma membrane ensures cytokine secretion in dendritic cells (DCs) and the initiation of immune responses. Despite its critical importance, the specific molecular components that regulate DC cytokine secretion are poorly characterised. Galectin-9, a ß-galactoside-binding protein, has emerged as a novel cellular modulator although its exact intracellular roles in regulating (immune) cell homeostasis and vesicle transport are virtually unknown. We investigated galectin-9 function in primary human DCs and report that galectin-9 is essential for intracellular cytokine trafficking to the cell surface. Galectin-9-depleted DCs accumulate cytokine-containing vesicles in the Golgi complex that eventually undergo lysosomal degradation. We observed galectin-9 to molecularly interact with Vamp-3 using immunoprecipitation-mass-spectrometry and identified galectin-9 was required for rerouting Vamp-3-containing endosomes upon DC activation as the underlying mechanism. Overall, this study identifies galectin-9 as a necessary mechanistic component for intracellular trafficking. This may impact our general understanding of vesicle transport and sheds new light into the multiple roles galectins play in governing cell function.
Graphical abstract
Einarbeitung junger Fachkräfte auf der Intensivstation
Authors: Josuttis David , Regner Frida , Deffner Teresa , Freund Diana , Freund Felix , Cornelius Celina , Beer Angelina , Spieckermann Aileen , Deininger Matthias Manfred 
Published: September 2023

Zusammenfassung
Hintergrund
Das Ankommen auf der Intensivstation ist für Fachkräfte entscheidend, um hochqualitative Patient:innenversorgung gewährleisten zu können. Dieser Prozess hängt von der Einarbeitungsqualität ab.

Ziel der Arbeit
Ziel der Arbeit ist die Erfassung von Art und Umfang der Einarbeitung und der Zufriedenheit von jungen Fachkräften auf der Intensivstation.

Material und Methoden
In einer anonymen, berufsgruppenübergreifenden Onlineumfrage wurde die Einarbeitungsstruktur sowie Zufriedenheit untersucht.

Ergebnisse
Von 554 Teilnehmenden kamen etwa zwei Drittel aus dem ärztlichen Bereich. Während bei der Pflege 59 % ein schriftliches Einarbeitungskonzept aufwiesen, lag ein solches nur bei 27 % der Ärzt:innen vor. Pflegefachpersonen gaben im Median 30 Tage als Einarbeitungszeit, Ärzt:innen 7 Tage an. Ein Drittel der Pflegefachpersonen stimmte der Aussage zu, ausreichend durch die Einarbeitung auf die intensivmedizinische Tätigkeit vorbereitet worden zu sein. Im ärztlichen Bereich fühlten sich nur 17 % der Teilnehmenden ausreichend durch die Einarbeitung vorbereitet. Mehr als 42 % der Befragten konnten sich vorstellen, noch länger als 3 Jahre in der Intensivmedizin tätig zu sein.

Diskussion
Evidenzbasierte Methoden zur Strukturierung der Einarbeitung von neuen Fachkräften sind in deutschen Intensivstationen nur gering verbreitet. Die Einarbeitungszeit liegt weit unter publizierten Empfehlungen. Auch wenn bezüglich der materiellen und personellen Ausstattung Defizite wahrgenommen werden, geben die meisten Befragten Zufriedenheit mit Lernzuwachs und interprofessioneller Zusammenarbeit an.
Restoration of preoperative tibial alignment improves functional results after medial unicompartmental knee arthroplasty
Authors: Micicoi Lolita , Machado Axel , Ernat Justin , Schippers Philipp , Bernard de Dompsure Régis , Bronsard Nicolas , Gonzalez Jean‐François , Micicoi Grégoire 
Published: September 2023

AbstractPurposeThe alignment obtained after unicompartmental knee arthroplasty (UKA) influences the risk of failure. Kinematic alignment after UKA based on Cartier angle restauration is likely to improve clinical outcomes compared with mechanical alignment. The purpose of this study is to analyze the influence of implant alignment and native knee restoration after UKA using the conventional techniques on clinical outcomes.MethodsThis retrospective study included 144 medial UKA patients from 2015 to 2020. Radiographic measurements were performed pre‐ and postoperatively. Outliers were defined as follows: Δ Cartier > 3° (difference between the preoperative and postoperative Cartier angle); Δ MPTA (Medial Proximal Tibial angle) and postoperative TCA (Tibial Coronal component Angle) > 3° (difference between the positioning of the tibial implant and the preoperative proximal tibial deformity). The Knee injury and Osteoarthritis Outcome Score (KOOS), the International Knee Society (IKS) Function and Knee score, the Forgotten Joint Score (FJS), and the Subjective Knee Value (SKV) were evaluated.A Student t test or a non‐parametric Wilcoxon test was used for non‐normal data to compare pre‐ and postoperative values for functional scores and angular measurements. The correlation of postoperative angles with functional outcomes was assessed by the Spearman’s rank correlation coefficient.ResultsDuring the inclusion period, 214 patients underwent medial UKA, 71 patients were excluded, and 19 were lost to follow‐up leaving 124 patients with 144 knees (20 bilateral UKA) included for analysis with a mean follow‐up of 54.7 months ± 22.1 (24–95). The Δ Cartier was significantly correlated with IKS function (R2 = 0.06, p < 0.001) and FJS (R2 = 0.05, p < 0.01) scores. The Δ preoperative MPTA–TCA was significantly correlated (p < 0.001) with KOOS (R2 = 0.38), IKS Knee (R2 = 0.17), IKS function (R2 = 0.34), SKV (R2 = 0.08), and FJS (R2 = 0.37) scores. In subgroup analysis, non‐outliers (< 3°) for Δ preoperative MPTA–TCA had better KOOS score (Δ = 23.5, p < 0.001) and IKS Function (Δ = 17.7, p < 0.001) compared to outliers (> 3°) patients.ConclusionFunctional results after medial UKA can be influenced by implant alignment in the coronal plane with slight clinical improvement when positioning the tibial implant close to the preoperative tibial deformity, rather than by restoring the Cartier angle. This series suggests the interest of a more personalized alignment strategy, but these results will have to be confirmed by other controlled studies.Level of evidenceIV, retrospective case series.
Development and feasibility of a telemedicine tool for patients with recurrent urinary tract infection: myRUTIcoach
Authors: Pat J. J. , Pape C. C. E. T , Steffens M. G. , Witte L. P. W. , Blanker M. H. 
Published: September 2023

Abstract
Introduction and hypothesis
Patients with recurrent urinary tract infection (rUTI) have limited knowledge of preventive strategies to lower the risk of UTI. We aimed to develop and test the feasibility of an eHealth system for women with rUTI, named myRUTIcoach, and explored the facilitators and barriers related to its adoption.

Methods
We developed myRUTIcoach in a structured iterative process and tested its feasibility among 25 women with rUTI over 2 months. Subsequent questionnaires covered satisfaction, accessibility, and experiences with myRUTIcoach. A random selection of participants and relevant stakeholders took part in semi-structured interviews to explore adoption. Data were analyzed and elaborated using inductive and deductive approaches using the Non-adoption, Abandonment, Spread, Scale-up, and Sustainability (NASSS) framework.

Results
MyRUTIcoach was not only widely accepted but also facilitated communication with health care professionals (HCPs) and contributed to greater knowledge of rUTI. Women graded the system a mean of 8.0 (±0.6) out of 10, with 89% stating that they would recommend it to others. Patients indicated that self-management skills were the major facilitators and barriers related to adoption, whereas HCPs stated that the disconnect between myRUTIcoach and electronic health care records (EHRs) was the major barrier.

Conclusions
This research describes the development and testing of myRUTIcoach for women with rUTI. Patients and HCPs reported high satisfaction and compliance with myRUTIcoach. However, adoption by the intended users is complex and influenced by all examined domains of the NASSS framework. We have already improved linkage to EHRs, but further optimization to meet patient needs may improve the effectiveness of this self-management tool for rUTI.
Involvement of NLRP3 inflammasome pathway in the protective mechanisms of ferulic acid and p-coumaric acid in LPS-induced sickness behavior and neuroinflammation in mice
Authors: Kinra Manas , Ranadive Niraja , Nampoothiri Madhavan , Arora Devinder , Mudgal Jayesh 
Published: September 2023

AbstractFerulic acid (FA) and p-coumaric acid (PCA) are abundantly present in commonly consumed food and beverages. Being polyphenolic compounds, they have been explored for their antioxidant and anti-inflammatory properties. Based on our previous study, we selected these two compounds to further investigate their potential in lipopolysaccharide (LPS)-induced sickness behavior and the ensuing neuroinflammation by specifically focusing on the NLRP3 inflammasome pathway. Male Swiss albino mice were divided into nine groups (n = 6) consisting of Normal Control, LPS, fluoxetine (FLX), FA40, FA160, FA640, PCA40, PCA160, and PCA640 respectively. Each group received respective FA or PCA treatment except Normal Control and LPS, which received the vehicle, carboxymethylcellulose 0.25% w/v. All groups were challenged with LPS 1.5 mg/kg, intraperitoneally except the Normal Control group, which received saline. Behavioral assessments were performed between 1–2 h, and the whole brains were collected at 3 h post-LPS administration. LPS-induced sickness behavior was characterized by significantly reduced spontaneous activity and high immobility time. The expression of NLRP3, ASC, caspase-1 and IL-1β was significantly increased, along with the levels of brain IL-1β suggesting the assembly and activation of NLRP3 inflammasome pathway. Furthermore, the major cytokines involved in sickness behavior, IL-6 and TNF-α were also significantly elevated with the accompanied lipid peroxidation. The results of this study emphasize that within the employed dose ranges of both FA and PCA, both the compounds were effective at blocking the activation of the NLRP3 inflammasome pathway and thereby reducing the release of IL-1β and the sickness behavior symptoms. There was a prominent effect on cytokine levels and lipid peroxidation as well.
Graphical abstract
Aromatic secondary metabolite production from glycerol was enhanced by amino acid addition in Pichia pastoris
Authors: Kumokita Ryota , Yoshida Takanobu , Shirai Tomokazu , Kondo Akihiko , Hasunuma Tomohisa 
Published: September 2023

Abstract
Aromatic secondary metabolites are widely used in various industries, including the nutraceutical, dietary supplement, and pharmaceutical industries. Their production currently relies on plant extraction. Microbe-based processes have recently attracted attention as sustainable alternatives to plant-based processes. We previously showed that the yeast Pichia pastoris (Komagataella phaffii) is an optimal host for producing aromatic secondary metabolites. Additionally, titers of resveratrol, an aromatic secondary metabolite, increased by 156 % when glycerol was used as a carbon source instead of glucose. However, the mechanisms by which glycerol resulted in higher production has remained unclear. In this study, we aimed to elucidate how P. pastoris produces higher levels of aromatic secondary metabolites from glycerol than from glucose. Titers of p-coumarate, naringenin, and resveratrol increased by 103 %, 118 %, and 157 %, respectively, in natural complex media containing glycerol compared with that in media containing glucose. However, the titers decreased in minimal synthetic medium without amino acids, indicating that P. pastoris cells used the amino acids only when glycerol was the carbon source. Fermentation with the addition of single amino acids showed that resveratrol titers from glycerol varied depending on the amino acid supplemented. In particular, addition of aspartate or tryptophan into the medium improved resveratrol titers by 146 % and 156 %, respectively. These results suggest that P. pastoris could produce high levels of aromatic secondary metabolites from glycerol with enhanced utilization of specific amino acids. This study provides a basis for achieving high-level production of aromatic secondary metabolites by P. pastoris.

Key points
•P. pastoris can produce high levels of aromatic metabolites from glycerol
•P. pastoris cells use amino acids only when glycerol is the carbon source
•Aromatic metabolite titers from glycerol increase with amino acids utilization
CT-Guided Liver Biopsy: Evaluation of Spectral Data From Dual-Layer Detector CT for Improved Lesion Detection
Authors: Sauter Andreas P. , Proksa Roland , Knipfer Andreas , Reischl Stefan , Braren Rickmer F. , Nadjiri Jonathan , Kopp Felix , Noël Peter B. , Makowski Markus R. , Rummeny Ernst J. , Fingerle Alexander A. 
Published: September 2023

Abstract
Purpose
Evaluation of dual-layer spectral computed tomography (CT) for contrast enhancement during image-guided biopsy of liver lesions using virtual monoenergetic images (VMI) and virtual non-contrast (VNC) images.

Methods
Spectral CT data of 20 patients receiving CT-guided needle biopsy of focal liver lesions were used to generate VMI at energy levels from 40 to 200 keV and VNC images. Images were analyzed objectively regarding contrast-to-noise ratio between lesion center (CNRcent) or periphery (CNRperi) and normal liver parenchyma. Lesion visibility and image quality were evaluated on a 4-point Likert scale by two radiologists.

Results
Using VMI/VNC images, readers reported an increased visibility of the lesion compared to the conventional CT images in 18/20 cases. In 75% of cases, the highest visibility was derived by VMI-40. Showing all reconstructions simultaneously, VMI-40 offered the highest visibility in 75% of cases, followed by VNC in 12.5% of cases. Either CNRcent (17/20) or/and CNRperi (17/20) was higher (CNR increase > 50%) in 19/20 cases for VMI-40 or VNC images compared to conventional CT images. VMI-40 showed the highest CNRcent in 14 cases and the highest CNRperi in 12 cases. High image quality was present for all reconstructions with a minimum median of 3.5 for VMI-40 and VMI-50.

Conclusions
When implemented in the CT scanner software, automated contrast enhancement of liver lesions during image-guided biopsy may facilitate the procedure.

Graphical Abstract
The Current Use of Drug-Eluting Balloons and Stents in Peripheral Arterial Disease: An Online Survey by the Cardiovascular and Interventional Radiological Society of Europe (CIRSE)
Authors: Morgan Robert A. , Müller-Hülsbeck Stefan , Fanelli Fabrizio , Haage Patrick , Hamady Mohamad , Loffroy Romaric , O’Sullivan Gerard , Wolf Florian , Slijepčević Birgit 
Published: September 2023

Abstract
Purpose
To assess the current use of drug-eluting devices for peripheral arterial disease (PAD) among interventional radiologists following the controversy caused by the 2018 meta-analysis suggesting an increased mortality risk for paclitaxel-eluting devices.

Methods
An anonymous survey was sent to 7035 CIRSE members via email; only complete responses were included and statistically analysed.

Results
Three hundred and seven members (4.4%) completed the survey. Among these, 95.8% indicated that they personally perform peripheral vascular procedures. Thirty-eight percentage of respondents did not see any change of practice since 2018, while 47% reported that the use of drug-eluting devices decreased; for 13%, the use stopped altogether, while it increased in 3% of responses. 45.6% of respondents also felt the impact of the controversy in terms of pricing, availability or directives from hospital administration. A large majority of respondents (83.7%) who perform peripheral vascular procedures consider the use of these devices as safe, 12.9% were undecided and 3.4% did not consider them as safe. Among the respondents who do not perform endovascular procedures, 77% considered these devices as safe and 23% were undecided.

Conclusion
Although the 2018 meta-analysis had a disruptive impact on the use of drug-eluting devices in PAD, with the increasing body of evidence available, a majority of respondents continue to believe in the safety of these devices for use in femoropopliteal disease.

Graphical Abstract
Celiac trunk thrombosis in a patient with antiphospholipid syndrome induced by median arcuate ligament compression: a case presentation and literature review
Authors: Janiak Paulina , Smoleńska Żaneta , Skotarczak Monika , Zdrojewski Zbigniew 
Published: September 2023

AbstractMedian arcuate ligament syndrome (MALS) is a rare disorder caused by the compression of the celiac axis by the fibrous structure of the diaphragm called the median arcuate ligament. Patients with MALS are usually undiagnosed unless characteristic symptoms such as nausea and vomiting, postprandial pain, and weight loss are presented. We report a case of a 29-year-old patient diagnosed with MALS and secondary antiphospholipid syndrome (APS) that developed celiac trunk, common hepatic artery and splenic artery thrombosis. There is not enough information on MALS as a trigger of thrombosis in predisposed patients such as those with APS. However, the case gives rise to suspicion and highlights the diagnostic processes, especially for patients with APS presenting postprandial abdominal pain and weight loss. This review likewise aims at the importance of Doppler ultrasonography as a screening tool and computer tomography (CT) or magnetic resonance (MR) both in the angiography variant, especially to diagnose confirmation and underlying treatment options.
Single-crystal and ceramic Yb:Lu2O3 gain media for thin-disk oscillators
Authors: Esser Stefan , Xu Xiaodong , Wang Jun , Zhang Jian , Graf Thomas , Abdou Ahmed Marwan 
Published: September 2023

AbstractWe report on the direct comparison of single-crystal and ceramic Yb3+:Lu203gain media with respect to emission spectra, fluorescence lifetime, depolarization, and laser performance in a continuous-wave thin-disk laser oscillator. The most efficient laser operation was achieved with a single-crystal disk in multimode operation with a slope efficiency of 72.1% and an average output power of 997 W. At the same temperature level, a ceramic disk delivered 861 W with a slope efficiency of 68.6%. In fundamental-mode operation, the highest average power of 360 W and highest optical efficiency of 41.3% were obtained with a ceramic disk. For the single-crystal disk, the fundamental-mode output power was limited to 113 W at an optical efficiency of 29%, potentially due to stress within the crystal.
Regional differences in clear cell metastatic renal cell carcinoma patients across the USA
Authors: Scheipner Lukas , Tappero Stefano , Piccinelli Mattia Luca , Barletta Francesco , Garcia Cristina Cano , Incesu Reha-Baris , Morra Simone , Baudo Andrea , Tian Zhe , Saad Fred , Shariat Shahrokh F. , Terrone Carlo , De Cobelli Ottavio , Briganti Alberto , Chun Felix K. H. , Tilki Derya , Longo Nicola , Carmignani Luca , Pichler Martin , Hutterer Georg , Ahyai Sascha , Karakiewicz Pierre I. 
Published: September 2023

Abstract
Purpose
To test for regional differences in clear cell metastatic renal cell carcinoma (ccmRCC) patients across the USA.

Methods
The Surveillance, Epidemiology, and End Results (SEER) database (2000–2018) was used to tabulate patient (age at diagnosis, sex, race/ethnicity), tumor (N stage, sites of metastasis) and treatment characteristics (proportions of nephrectomy and systemic therapy), according to 12 SEER registries. Multinomial regression models, as well as multivariable Cox regression models, tested the overall mortality (OM) adjusting for those patient, tumor and treatment characteristics.

Results
In 9882 ccmRCC patients, registry-specific patient counts ranged from 4025 (41%) to 189 (2%). Differences across registries existed for sex (24–36% female), race/ethnicity (1–75% non-Caucasian), N stage (N1 25–35%, NX 3–13%), proportions of nephrectomy (44–63%) and systemic therapy (41–56%). Significant inter-registry differences remained after adjustment for proportions of nephrectomy (46–63%) and systemic therapy (35–56%). Unadjusted 5-year OM ranged from 73 to 85%. In multivariable analyses, three registries exhibited significantly higher OM (SEER registry 5: hazard ratio (HR) 1.20, p = 0.0001; SEER registry 7:HR 1.15, p = 0.008M SEER registry 10: HR 1.15, p = 0.04), relative to the largest reference registry (n = 4025).

Conclusion
Important regional differences including patient, tumor and treatment characteristics exist, when ccmRCC patients included in the SEER database are studied. Even after adjustment for these characteristics, important OM differences persisted, which may require more detailed analyses to further investigate these unexpected differences.
Present state of intestinal transplantation in Japan
Authors: Ueno Takehisa , Wada Motoshi , Ogawa Eri , Matsuura Toshiharu , Yamada Yohei , Sakamoto Seisuke , Okuyama Hiroomi 
Published: September 2023

Abstract
Introduction
Intestinal transplantation (ITx) is the ultimate treatment for intestinal failure (IF). In Japan, most cases of IF are a result of pediatric disease, including secondary or congenital intestinal disease or allied disorders of Hirschsprung’s disease. Here, we report the results of the Japanese ITx registry.

Methods
A web-based survey form was completed. We investigated the number, age, sex, indication, surgical procedure, immunosuppressants, postoperative course, and the effects of transplantation in patients who underwent cadaveric or living-donor ITx.

Results
By the end of 2022, 42 cases of ITx have been performed in 38 patients in Japan. The donor sources included cadavers (29 cases) and living donors (13 cases). The surgical method was isolated ITx (N = 40) and combined liver and ITx (n = 2). Survival rates were 92%, 73%, and 59% at 1 year, 5 years, and 10 years, respectively. Ninety percent of patients completely discontinued parenteral nutrition. Approximately 80% of the patients had a performance status of 1 or less, indicating that the QOL of patients after ITx was extremely good.

Conclusion
The results of ITx are acceptable to treat IF patients and the QOL after transplantation is also good.