bluuebunny/crossref_metadata_2025_split huggingface dataset:
Organization of teaching mathematics in primary school
Authors: Крайнова О.А. , Мамедова Л.В. 
Published: July 2023

Актуальность исследования по теме организация обучения математике в начальных класса заключается в том, математическое развитие играет важную роль в развитии ребенка, так как математические знания, сформированные в начальных класса являются фундаментальными для всех остальных знаний, которые человек будет приобретать в будущем и «наслаивать» их на имеющуюся базу. Интегрированный курс начальной математики включает в себя арифметические, геометрические и алгебраические разделы, что позволяет детям с младшего возраста понимать универсальность математических способов познания мира. Они усваивают начальные знания математики, связывая их с окружающей действительностью и другими учебными предметами. Разрешение задач, предлагаемых на уроках, помогает развивать познавательные способности и заинтересованность в расширении математических знаний у детей. Для комфортного преподавания математики необходимо создание благоприятных условий на уроках для общего интеллектуального развития каждого ученика. При этом важно учитывать возрастные характеристики и возможности каждого ребенка, обеспечивая достаточную математическую подготовку для дальнейшего обучения. В данной статье рассматривается теоретический аспект изучения организации обучения математике в начальных классах, методы обучения детей математике, а также программы, в которых развернуто рассматривается раздел математики.
The relevance of the study on the organization of teaching mathematics in the primary grades lies in the fact that mathematical development plays an important role in the development of the child, since the mathematical knowledge formed in the primary grades is fundamental for all other knowledge that a person will acquire in the future and “layer” them to the existing base. The integrated elementary mathematics course includes arithmetic, geometric and algebraic sections, which allows children from a young age to understand the universality of mathematical ways of knowing the world. They learn the basic knowledge of mathematics, connecting them with the surrounding reality and other academic subjects. Solving the problems offered in the lessons helps to develop cognitive abilities and interest in expanding mathematical knowledge in children. For comfortable teaching of mathematics, it is necessary to create favorable conditions in the classroom for the overall intellectual development of each student. At the same time, it is important to take into account the age characteristics and capabilities of each child, providing sufficient mathematical preparation for further education. This article discusses the theoretical aspect of studying the organization of teaching mathematics in primary school, methods of teaching children mathematics, as well as programs in which the section of mathematics is considered in detail.
GENERATION OF SYNTHETIC RAINFALL DATA IN SEKAYAM SUB-WATERSHED BASED ON TRMM SATELLITE RAINFALL DATA CORRECTION EQUATION
Authors: Iwansyah Iwansyah , Soeryamassoeka SB. , Yulianto Eko 
Published: July 2023

The hydrological analysis is the first stage of the review in waterworks planning. Hydrological analysis necessitates the availability of sufficient data. Data availability tends to have several problems, including a lack of availability, incomplete/empty data, a smaller number of stations, observers, and observation systems, data entry that is still manual, and slow data collection. One possible solution is to use rain satellites. However, TRMM data must be evaluated for field suitability. TRMM (Tropical Rainfall Measurement Mission) rainfall data can help overcome this. TRMM is a NASA mission that uses weather monitoring satellite technology to monitor tropical rainfall. This is also the case for the Sekayam Subwatershed, part of the Kapuas River Basin.In the Sekayam sub-watershed, there are 14 (fourteen) rainfall observation stations managed by the Balai Wilayah Sungai Kalimantan (BWSK) I, but currently only 5 observation stations are still active, namely the SGU-01 Sanggau, SGU-03 Balai Karangan, SGU-06 Entikong, SGU-19 Semuntai and SC-01 Kembayan observation stations with data recorded up to 2019, while the other 9 (nine) observation stations do not have long continuous data, because there are years where rainfall data is not recorded. This is because the recording of rainfall on average stopped until 2005, or even some have stopped operating since the 1990s or early 2000s. This study aims to generate representative synthetic TRMM daily rainfall amount data for the Sekayam sub-watershed based on the correction equations obtained in a series of TRMM rainfall data validation analyses, so that it can be used as alternative daily rainfall data in water resources planning and management in the Sekayam sub-watershed. From the analysis, it can be seen that synthetic rainfall data in the Sekayam sub-watershed will be valid if it is generated with the linear model correction equation Y = 0.6708 X + 139.123 or can be interpreted as TRMM' = 0.6708 TRMM + 139.123.
Effect of Earning Management on the Stock Price of Enterprises Listed in Ho Chi Minh City in the Period of Covid 2019-2021
Authors: Xuan Thach Ha , Thanh Quy Tran Thi , Minh Hieu Ha Truong 
Published: July 2023

Purpose: The aim of this study is to examine the phenomenon of earnings management (EM) and its impact on stock prices, providing valuable empirical evidence in this field.

Theoretical framework: Agency theory suggests that profit management behavior comes from conflicts between managers and shareholders. The efficient market theory assumes that information will be reflected in stock prices.

Design/methodology/approach: To achieve the research objectives, the study analyzes the financial statements (FRQs) of 74 enterprises listed on the Ho Chi Minh Stock Exchange in Ho Chi Minh City. The data collected in the period from 2019 to 2021, Covid-19 pandemic and analysis by GSEM.

Findings: Specifically, the study shows that earnings management exerts a direct negative impact on stock prices. Additionally, it highlights the positive influence of EM on the quality of FRQ information. However, the quality of FRQ news demonstrates a negative effect on stock prices. The study also investigates the role of intermediate variables in the relationship between financial reporting information quality and stock prices.

Research, Practical & Social implications: By providing empirical evidence and highlighting the significance of accounting practices in the capital market, the study adds value to academic research, while offering practical insights for investors, regulators, and businesses.

Originality/value: By providing empirical evidence and highlighting the significance of accounting practices in the capital market, the study adds value to academic research, while offering practical insights for investors, regulators, and businesses.
The results of the application of growth-stimulating preparations of a new generation in the cultivation of a number of green cabbage varieties
Authors: Bondarenko Anastasia Nikolaevna , Petrov Evgeny Nikolaevich 
Published: July 2023

Field studies on the cultivation of green cabbage varieties and hybrids using various growth stimulants against the background N120P60K60 were carried out on an irrigated area located at a distance of 1.5 km northwest of the village Solenoe Zaimishche (Astrakhan region) on an irrigated land use area of FSBNU "Pre-Caspian Agrarian Federal Scientific Center of the Russian Academy of Sciences." As a result of the obtained study, the positive effect of leaf treatments during the entire vegetation period was established. Especially the best effect was after joint application of Novosil + N120P60K60 in the hybrid Aggressor F1. At the same time, the yield was 57.5 tons/ha with an increase to the control variant of 15.7 tons/ha.
Kebahagiaan pada Pendakwah Muslim
Authors: Mildaeni Itsna Nurrahma , Herdian Herdian 
Published: July 2023

Islam sebagai agama mayoritas masyarakat Indonesia memiliki nilai-nilai yang dianut oleh seorang muslim yang mempengaruhi konsep dan cara pandang dalam memandang kehidupan termasuk terhadap kebahagiaan. Penelitian ini bertujuan menganalisa faktor-faktor yang menentukan kebahagiaan seorang muslim. Penelitian ini menggunakan pendekatan kualitatif yang dilakukan dengan metode survei dengan kuesioner terbuka (open ended questionnaire). Partisipan penelitian adalah 40 orang muslim yang terdiri dari 20 orang laki-laki dan 20 orang perempuan. Hasil penelitian menemukan kebahagiaan pada muslim berkaitan dengan keluarga (55%), hubungan sosial (18%), rezeki (10%), konsep spiritualitas dan religiusitas (18%). Penelitian membuktikan bahwa kebahagiaan seorang muslim meliputi unsur fisik, psikis, sosial, dan spiritual dan religiusitas. Implikasi dan pembahasan didiskusikan.
Osmanlı Matbuatına Göre Hasan Fehmi Cinayeti
Authors: GÜNEŞ Hüseyin 
Published: July 2023

Osmanlı İmparatorluğu’nun çöküşten kurtarılması adına ilan edilen II. Meşrutiyet ilk etapta toplumun hemen hemen tüm kesimlerinde olumlu bir karşılık buldu. Fakat bu süreçte gelişen iç ve dış hadiseler beklentilerin aksine durumun daha da kötüleşmesine neden oldu. Yeni dönemin ana aktörü İttihat ve Terakki Cemiyeti ile muhalifleri arasında başlayan mücadele ortaya pek çok yeni sorun çıkardı. Toprak kayıpları, azınlıkların ayrılıkçı tutumları, muhalif gruplarla mücadele ve matbuatın sınırsız özgürlük ortamında geliştirdiği tavır bu dönemin dikkati çeken olaylarıdır.
Serbestî gazetesi başmuharriri ve muhalif bir gazeteci olan Hasan Fehmi Bey’in 6/7 Nisan 1909 gecesi Galata köprüsü üzerinde suikasta uğraması ve katilin yakalanamayışı cinayetin İttihat ve Terakki tarafından işlendiği iddiasını gündeme getirdi. Cemiyet muhalifleri, basın organları başta olmak üzere farklı platformlarda bu iddiayı genel kabul haline getirmeye çalıştılar. İttihat ve Terakki ise kendisini bu töhmetten kurtarmaya çalıştı.31 Mart Vakasının hemen öncesinde meydana gelen bu fail-i meçhul cinayet daha sonraki dönemlerde de tartışılmasına rağmen hiçbir zaman aydınlatılamadı. Fakat etkileri bakımından önemli bir hadise olarak tarihteki yerini aldı.
Glucose promoting the early embryonic development by increasing the lipid synthesis at 2-cell stage
Authors: Wang Mingwen , Xue Jinfeng , Li Chanyi , Qi Lingbin , Nie Lan , Xue Zhigang 
Published: July 2023

The optimization of culture conditions is one of the main strategies to improve the embryo development competence in in vitro fertilization (IVF). Glucose is an important carbon source while also exists in the oviductal fluid in vivo, the effect of glucose in embryo development microenvironment is still unclear. Here we employed the LC-MS to detect and analyze the metabolites in the culture medium of different cleavage stages including 2-Cell, 4-Cell and 8-Cell mouse embryos, respectively. The effects of the external glucose were estimated by measuring the development rate at different glucose concentrations from 0 to 5 mmol/L, and the gene expression changes were detected to explore the potential mechanism after the addition of glucose in the media. Our results indicated the 2-Cell and 8-Cell stages had defined characteristic metabolites, while 4-Cell stage was the transition state. Global and contiguous metabolic characteristics showed the glycometabolism play a critical role at each early cleavage stages during the embryo development. The 8-Cell rates demonstrated the addition of glucose in culture media significantly improve the embryo competence, the highest rate was 87.33% using 3 mmol/L glucose in media, in contrast only 9.95% using the media without glucose. Meanwhile, the blocked embryos were mainly enriched at 2-Cell stage. Further transcriptome study found 3 mmol/L glucose in media remarkably upregulated the gene expression of lipid biosynthesis at 2-Cell stage, the increased lipid was confirmed by nile red staining. These data indicated the glucose may promote the development competence through increasing the lipid biosynthesis to overcoming the 2-Cell block. Our findings were helpful for the further optimization of IVF culture media, as well as the estimation of embryo quality using metabolites in the culture media.
Shortening identification times: comparative observational study of three early blood culture testing protocols
Authors: Chatelard Paul-Antoine , Rousseau Nathalie , Parmeland Laurence , Metral Pierre , Pariset Caroline , Vivier Emmanuel 
Published: July 2023

BackgroundWhile early appropriate antibiotic therapy is a proven means of limiting the progression of infections, especially bacteremia, empirical antibiotic therapy in sepsis is ineffective up to 30%. The aim of this study was to compare early blood culture testing protocols in terms of their ability to shorten the delay between blood sampling and appropriate antibiotic therapy.MethodsIn this french observational study, we compared three blood culture testing protocols. Positive blood cultures were tested using either GenMark ePlex panels (multiplex PCR period), a combination of MRSA/SA PCR, β-Lacta and oxidase tests (multitest period), or conventional identification and susceptibility tests only (reference period). Conventional identification and susceptibility tests were performed in parallel for all samples, as the gold standard.ResultsAmong the 270 patients with positive blood cultures included, early and conventional results were in good agreement, especially for the multitest period. The delay between a blood culture positivity and initial results was 3.8 (2.9–6.9) h in the multiplex PCR period, 2.6 (1.3–4.5) h in the multitest period and 3.7 (1.8–8.2) h in the reference period (p&lt;0.01). Antibiotic therapy was initiated or adjusted in 68 patients based on early analysis results. The proportion of patients receiving appropriate antibiotic therapy within 48 h of blood sampling was higher in the multiplex PCR and multitest periods, (respectively 90% and 88%) than in the reference period (71%).ConclusionThese results suggest rapid bacterial identification and antibiotic resistance tests are feasible, efficient and can expedite appropriate antibiotic therapy.
The effect of peak serum estradiol level during ovarian stimulation on cumulative live birth and obstetric outcomes in freeze-all cycles
Authors: Huang Jiaan , Lu Yao , He Yaqiong , Wang Yuan , Zhu Qinling , Qi Jia , Ding Ying , Zhao Hanting , Ding Ziyin , Sun Yun 
Published: July 2023

ObjectiveTo determine whether the peak serum estradiol (E2) level during ovarian stimulation affects the cumulative live birth rate (CLBR) and obstetric outcomes in freeze-all cycles.MethodsThis retrospective cohort study involved patients who underwent their first cycle of in vitro fertilization followed by a freeze-all strategy and frozen embryo transfer cycles between January 2014 and June 2019 at a tertiary care center. Patients were categorized into four groups according to quartiles of peak serum E2 levels during ovarian stimulation (Q1-Q4). The primary outcome was CLBR. Secondary outcomes included obstetric and neonatal outcomes of singleton and twin pregnancies. Poisson or logistic regression was applied to control for potential confounders for outcome measures, as appropriate. Generalized estimating equations were used to account for multiple cycles from the same patient for the outcome of CLBR.Result(s)A total of 11237 patients were included in the analysis. Cumulatively, live births occurred in 8410 women (74.8%). The live birth rate (LBR) and CLBR improved as quartiles of peak E2 levels increased (49.7%, 52.1%, 54.9%, and 56.4% for LBR; 65.1%, 74.3%, 78.4%, and 81.6% for CLBR, from the lowest to the highest quartile of estradiol levels, respectively, P&lt;0.001). Such association remained significant for CLBR after accounting for potential confounders in multivariable regression models, whereas the relationship between LBR and peak E2 levels did not reach statistical significance. In addition, no significant differences were noticed in adverse obstetric and neonatal outcomes (gestational diabetes mellitus, pregnancy-induced hypertension, preeclampsia, placental disorders, preterm birth, low birthweight, and small for gestational age) amongst E2 quartiles for either singleton or twin live births, both before and after adjustment.ConclusionIn freeze-all cycles, higher peak serum E2 levels during ovarian stimulation were associated with increased CLBR, without increasing the risks of adverse obstetric and neonatal outcomes.
GDF10 is related to obesity as an adipokine derived from subcutaneous adipose tissue
Authors: Song Mi Kyung , Kim Ji Eun , Kim Jung Tae , Kang Yea Eun , Han Sun Jong , Kim Seok Hwan , Kim Hyun Jin , Ku Bon Jeong , Lee Ju Hee 
Published: July 2023

IntroductionAdipokines are proteins that are secreted by the adipose tissue. Although they are associated with obesity-related metabolic disorders, most studies have focused on adipokines expressed by visceral adipose tissue (VAT). This study aimed to identify the adipokine potentially derived from subcutaneous adipose tissue (SAT) and its clinical significance.MethodsSamples of SAT and VAT were obtained from six adult male patients who underwent laparoscopic surgery for benign gall bladder disease. Differentially expressed genes were analyzed by subjecting the samples to RNA sequencing. The serum concentration of selected proteins according to body mass index (BMI) was analyzed in 58 individuals.ResultsGDF10 showed significantly higher expression in the SAT, as per RNA sequencing (fold change = 5.8, adjusted P value = 0.009). Genes related to insulin response, glucose homeostasis, lipid homeostasis, and fatty acid metabolism were suppressed when GDF10 expression was high in SAT, as per genotype-tissue expression data. The serum GDF10 concentration was higher in participants with BMI ≥ 25 kg/m2 (n = 35, 2674 ± 441 pg/mL) than in those with BMI &lt; 25 kg/m2 (n = 23, 2339 ± 639 pg/mL; P = 0.022). There was a positive correlation between BMI and serum GDF10 concentration (r = 0.308, P = 0.019).ConclusionsGDF10 expression was higher in SAT than in VAT. Serum GDF10 concentration was high in patients with obesity. Therefore, GDF10 could be a SAT-derived protein related to obesity.
UBR4 deficiency causes male sterility and testis abnormal in Drosophila
Authors: Xie Shi-Ming , Lai Jia-Xuan , Liu Chu-Qiao , Zhang Xi-Xing , Lin Yong-Miao , Lan Qi-Wen , Hong De-Yao , Chen Xiao-Chuan , Qiao Jing-Da , Mao Yu-Ling 
Published: July 2023

IntroductionIt has been established that UBR4 encodes E3 ubiquitin ligase, which determines the specificity of substrate binding during protein ubiquitination and has been associated with various functions of the nervous system but not the reproductive system. Herein, we explored the role of UBR4 on fertility with a Drosophila model.MethodsDifferent Ubr4 knockdown flies were established using the UAS/GAL4 activating sequence system. Fertility, hatchability, and testis morphology were studied, and bioinformatics analyses were conducted. Our results indicated that UBR4 deficiency could induce male sterility and influent egg hatchability in Drosophila.ResultsWe found that Ubr4 deficiency affected the testis during morphological analysis. Proteomics analysis indicated 188 upregulated proteins and 175 downregulated proteins in the testis of Ubr4 knockdown flies. Gene Ontology analysis revealed significant upregulation of CG11598 and Sfp65A, and downregulation of Pelota in Ubr4 knockdown flies. These proteins were involved in the biometabolic or reproductive process in Drosophila. These regulated proteins are important in testis generation and sperm storage promotion. Bioinformatics analysis verified that UBR4 was low expressed in cryptorchidism patients, which further supported the important role of UBR4 in male fertility.DiscussionOverall, our findings suggest that UBR4 deficiency could promote male infertility and may be involved in the protein modification of UBR4 by upregulating Sfp65A and CG11598, whereas downregulating Pelota protein expression.
Mets-IR as a predictor of cardiovascular events in the middle-aged and elderly population and mediator role of blood lipids
Authors: Qian Taoming , Sheng Xiaomeng , Shen Pengyu , Fang Yuting , Deng Yao , Zou Guoliang 
Published: July 2023

BackgroundCardiovascular disease (CVD) is a global health concern, with a significant impact on morbidity and mortality rates. Using fasting glucose, fasting triglycerides, body mass index (BMI), and high-density lipoprotein cholesterol (HDL-C), the metabolic score of insulin resistance (Mets-IR), a novel index created by Mexican researchers to assess insulin sensitivity, is a more precise way to measure insulin sensitivity. This study aimes to explore the association between Mets-IR and CVD, as well as investigate the potential mediating role of of low-density lipoprotein cholesterol (LDL-C).MethodsThe study’s data came from the 2011 and 2018 China Health and Retirement Longitudinal Studies (CHARLS). We used three logistic regression models to account for the potential effects of ten factors on cardiovascular disease/stroke/heart disease. Moreover, We performed mediation analyses to evaluate the role of LDL-C in the association between Mets-IR and incident CVD.ResultsThis study comprised 4,540 participants, of whom 494 (10.88%) were found to develop disease (CVD). Each interquartile range (IQR) increased in Mets-IR raised the risk of developing CVD by 38% (OR=1.38; 95% CI, 1.21-1.56) and there was a linear dose-response relationship between Mets-IR and the risk of new-onset cardiovascular disease, stroke, and heart disease (Poverall&lt;0.05, Pnon-linear&gt;0.05). Approximately 5% (indirect effect/total effect) of the significant association of Mets-IR with stroke was mediated by LDL-C, respectively. With the addition of Mets-IR to the base model, the continuous net reclassification improvement and integrated discrimination improvement for predicting cardiovascular disease increased by 0.175 (P &lt;0.001) and 0.006 (P &lt;0.001), respectively.Conclusionets-IR is associated with an increased risk of cardiovascular disease/stroke/cardiac issues, with LDL-C mediating these relationships. Improving insulin sensitivity and lipid regulation may be essential and effective preventive measures for cardiovascular events.
Epigenetic associations with adolescent grey matter maturation and cognitive development
Authors: Jensen Dawn , Chen Jiayu , Turner Jessica A. , Stephen Julia M. , Wang Yu-Ping , Wilson Tony W. , Calhoun Vince D. , Liu Jingyu 
Published: July 2023

Introduction: Adolescence, a critical phase of human neurodevelopment, is marked by a tremendous reorganization of the brain and accompanied by improved cognitive performance. This development is driven in part by gene expression, which in turn is partly regulated by DNA methylation (DNAm).Methods: We collected brain imaging, cognitive assessments, and DNAm in a longitudinal cohort of approximately 200 typically developing participants, aged 9–14. This data, from three time points roughly 1 year apart, was used to explore the relationships between seven cytosine–phosphate–guanine (CpG) sites in genes highly expressed in brain tissues (GRIN2D, GABRB3, KCNC1, SLC12A9, CHD5, STXBP5, and NFASC), seven networks of grey matter (GM) volume change, and scores from seven cognitive tests.Results: The demethylation of the CpGs as well as the rates of change in DNAm were significantly related to improvements in total, crystalized, and fluid cognition scores, executive function, episodic memory, and processing speed, as well as several networks of GM volume increases and decreases that highlight typical patterns of brain maturation.Discussion: Our study provides a first look at the DNAm of genes involved in myelination, excitatory and inhibitory receptors, and connectivity, how they are related to the large-scale changes occurring in the brain structure as well as cognition during adolescence.