bluuebunny/crossref_metadata_2025_split huggingface dataset:
Expunged and Forgotten Texts and Messages of Vatican II
Authors: Melloni Alberto 
Published: January 2023

Abstract
After the conclusion of the council in 1965, many scholars, publishers, ecclesiastical opinion leaders, and bishops wrote their own commentaries on Vatican II. This literary genre was inclined to ignore what happened at the council and to concentrate on the decisions. In this way, many acts of the council were minimized or were simply ignored—even acts like the messages to the world at the beginning and end of Vatican II and the withdrawal of excommunications between Rome and Constantinople. Other crucial moves of the council were neglected or considered beyond the formal corpus of the documents of Vatican II. The most important of these is Gaudet Mater Ecclesia, the opening address of the council where John XXIII offered his hermeneutical views and expectations. But other steps—the first announcement of Vatican II, the signature of Paul VI—are also important keys to Vatican II: not as a machine producing decisions, but as an event creating an epochal turn in the history of the Roman Catholic Church.
The Ecclesiology of Vatican II
Authors: Gaillardetz Richard 
Published: January 2023

Abstract
Although the Second Vatican Council was mainly concerned with ecclesiology, one cannot find in the documents a single internally coherent fundamental theology of the Church. This is not surprising, given the challenges the council faced in its efforts to integrate the many ecclesiological developments that occurred in the first half of the twentieth century. However, a careful study of the documents, read in the light of the last six decades of the council’s reception, allows us to identify significant conciliar contributions to ecclesiology that coalesce around five themes: (1) the liturgico-sacramental foundation of the Church, (2) the Church’s Trinitarian origins and eschatological destiny, (3) the Church’s missionary nature, (4) the Church’s ecumenical commitment, and (5) the Church’s collegial exercise of authority.
Impact of engineering the ATP synthase rotor ring on photosynthesis in tobacco chloroplasts
Authors: Yamamoto Hiroshi , Cheuk Anthony , Shearman Julia , Nixon Peter J , Meier Thomas , Shikanai Toshiharu 
Published: January 2023

Abstract
The chloroplast ATP synthase produces the ATP needed for photosynthesis and plant growth. The trans-membrane flow of protons through the ATP synthase rotates an oligomeric assembly of c subunits, the c-ring. The ion-to-ATP ratio in rotary F1F0-ATP synthases is defined by the number of c-subunits in the rotor c-ring. Engineering the c-ring stoichiometry is, therefore, a possible route to manipulate ATP synthesis by the ATP synthase and hence photosynthetic efficiency in plants. Here, we describe the construction of a tobacco (Nicotiana tabacum) chloroplast atpH (chloroplastic ATP synthase subunit c gene) mutant in which the c-ring stoichiometry was increased from 14 to 15 c-subunits. Although the abundance of the ATP synthase was decreased to 25% of wild-type (WT) levels, the mutant lines grew as well as WT plants and photosynthetic electron transport remained unaffected. To synthesize the necessary ATP for growth, we found that the contribution of the membrane potential to the proton motive force was enhanced to ensure a higher proton flux via the c15-ring without unwanted low pH-induced feedback inhibition of electron transport. Our work opens avenues to manipulate plant ion-to-ATP ratios with potentially beneficial consequences for photosynthesis.
The art of shared decision making
Authors: Bingaman Luke 
Published: January 2023

ABSTRACT
Now more than ever, we know that there is uncertainty in medicine. Over the past 2 years, we have witnessed the evolution of knowledge that occurs in medicine and how this informs medical recommendations. Similarly, we have learned that patients have varying levels of risk tolerance, goals, and values. Although this is not a new reality, the COVID-19 pandemic has put it on display. Shared decision making is a tool for clinicians to use that recognizes this reality, honors the individuality of each patient, and guides us to the best decision for each patient.
Which patient factors increase the risk of fluoroquinolone-associated reactions?
Authors: Warunek Letitia N. , Smith Susan M. 
Published: January 2023

ABSTRACT
Fluoroquinolones commonly are used to treat a variety of infections in the urinary, gastrointestinal, and respiratory tracts. Clinicians should evaluate patients to ensure that a fluoroquinolone is a safe and effective therapy to treat the infection. This article discusses patient factors that increase the risk for serious adverse drug reactions that can occur with fluoroquinolone use.
Managing Older Adults' Chronic Pain: Lower-Risk Interventions
Authors: Arnstein Paul , Shade Marcia , Herr Keela A. , Young Heather M. , Fishman Scott M. 
Published: January 2023

This article is part of a series, Supporting Family Caregivers: No Longer Home Alone, published in collaboration with the AARP Public Policy Institute. Results of focus groups, conducted as part of the AARP Public Policy Institute's No Longer Home Alone video project, supported evidence that family caregivers aren't given the information they need to manage the complex care regimens of family members. This series of articles and accompanying videos aims to help nurses provide caregivers with the tools they need to manage their family member's health care at home.
This new group of articles provides practical information nurses can share with family caregivers of persons living with pain. To use this series, nurses should read the articles first, so they understand how best to help family caregivers. Then they can refer caregivers to the informational tear sheet—Information for Family Caregivers—and instructional videos, encouraging them to ask questions. For additional information, see Resources for Nurses.
Spiritual Care as a Core Component of Palliative Nursing
Authors: Miller Megan , Addicott Katie , Rosa William E. 
Published: January 2023

ABSTRACT:
Spirituality is one aspect of the human experience that is unique to each person and may become especially important in the face of life-threatening illness. While evidence supports the need to address spirituality as part of holistic palliative care nursing, it is hoped that “spiritual care” will not become another item on nurses' to-do list, but rather will be part of nurses' everyday lives and nursing practice. Taking time to assess personal needs, and consciously connecting to meaning, hope, and peace, can support nurses' return to the deeper roots of nursing. Addressing spirituality as part of palliative nursing care can also acknowledge the complex and multidimensional experiences of the patients that nurses serve. Connecting, or reconnecting, with nurses' unique sense of spirituality can serve as a powerful resource for resilience. This article highlights the relevance of spiritual care to palliative nursing and offers practical tips to incorporate spiritual care into everyday nursing practice.
The impact of systemic racism on health outcomes among Black women
Authors: James-Conterelli Sascha , Dunkley Daihnia , McIntosh Jennifer T. , Julien Tamika , Nelson Maurice D. , Richard-Eaglin Angela 
Published: January 2023

Abstract:
Black women suffer disproportionately from healthcare inequities in comparison to their White counterparts. Using the Public Health Critical Race framework, this article explores the lasting effects of systemic racism on the health outcomes of Black women across the lifespan. A case study and specific strategies are presented to examine how clinicians, educators, and policymakers can work with Black women to mitigate and eliminate health inequities.
Angiopoietin-Like4 Is a Novel Marker of COVID-19 Severity
Authors: Bhatraju Pavan K. , Morrell Eric D. , Stanaway Ian B. , Sathe Neha A. , Srivastava Avantika , Postelnicu Radu , Green Richard , Andrews Adair , Gonzalez Martin , Kratochvil Christopher J. , Kumar Vishakha K. , Hsiang Tien-Ying , Gale Michael , Anesi George L. , Wyles David , Broadhurst M. Jana , Brett-Major David , Mukherjee Vikramjit , Sevransky Jonathan E. , Landsittel Douglas , Hung Chi , Altemeier William A. , Gharib Sina A. , Uyeki Timothy M. , Cobb J. Perren , Liebler Janice M. , Crosslin David R. , Jarvik Gail P. , Segal Leopoldo N. , Evans Laura , Mikacenic Carmen , Wurfel Mark M. 
Published: January 2023

IMPORTANCE:
Vascular dysfunction and capillary leak are common in critically ill COVID-19 patients, but identification of endothelial pathways involved in COVID-19 pathogenesis has been limited. Angiopoietin-like 4 (ANGPTL4) is a protein secreted in response to hypoxic and nutrient-poor conditions that has a variety of biological effects including vascular injury and capillary leak.

OBJECTIVES:
To assess the role of ANGPTL4 in COVID-19–related outcomes.

DESIGN, SETTING, AND PARTICIPANTS:
Two hundred twenty-five COVID-19 ICU patients were enrolled from April 2020 to May 2021 in a prospective, multicenter cohort study from three different medical centers, University of Washington, University of Southern California and New York University.

MAIN OUTCOMES AND MEASURES:
Plasma ANGPTL4 was measured on days 1, 7, and 14 after ICU admission. We used previously published tissue proteomic data and lung single nucleus RNA (snRNA) sequencing data from specimens collected from COVID-19 patients to determine the tissues and cells that produce ANGPTL4.

RESULTS:
Higher plasma ANGPTL4 concentrations were significantly associated with worse hospital mortality (adjusted odds ratio per log2 increase, 1.53; 95% CI, 1.17–2.00; p = 0.002). Higher ANGPTL4 concentrations were also associated with higher proportions of venous thromboembolism and acute respiratory distress syndrome. Longitudinal ANGPTL4 concentrations were significantly different during the first 2 weeks of hospitalization in patients who subsequently died compared with survivors (p for interaction = 8.1 × 10–5). Proteomics analysis demonstrated abundance of ANGPTL4 in lung tissue compared with other organs in COVID-19. ANGPTL4 single-nuclear RNA gene expression was significantly increased in pulmonary alveolar type 2 epithelial cells and fibroblasts in COVID-19 lung tissue compared with controls.

CONCLUSIONS AND RELEVANCE:
ANGPTL4 is expressed in pulmonary epithelial cells and fibroblasts and is associated with clinical prognosis in critically ill COVID-19 patients.
Use of Aerosolized Prostacyclins in Critically Ill Patients and Association With Clinical Outcomes
Authors: Hussain S. Talal , Jaliawala Huzaifa A. , Zhao Daniel , Ijaz Sardar Hassan , Tsui Janice , Chasteen Bobby , Brown Brent R. , Bernardo Roberto J. 
Published: January 2023

IMPORTANCE:
Aerosolized prostacyclins are frequently used in patients with severe acute respiratory distress syndrome and refractory hypoxia. Previous studies have shown improvement in oxygenation with use of pulmonary vasodilators such as iloprost and epoprostenol; however, there is no head-to-head comparison between these agents.

OBJECTIVES:
To compare the effects of inhaled epoprostenol and inhaled iloprost in critically ill patients with refractory hypoxia.

DESIGN, SETTING, AND PARTICIPANTS:
We performed a retrospective cohort analysis of patients admitted to the ICUs at the University of Oklahoma Health Sciences Center between 2015 and 2018. Adult patients who received aerosolized epoprostenol or iloprost for more than 4 hours were included in the analysis.

MAIN OUTCOMES AND MEASURES:
The primary endpoint measured was to compare the change in Pao
2/Fio
2 ratio between patients treated with iloprost compared with epoprostenol. Secondary outcomes measured were 90-day in-hospital mortality and improvement in vasopressor requirements.

RESULTS:
A total of 126 patients were included in the study, 95 of whom received iloprost (75%) and 31 patients (25%) received epoprostenol. There were significant improvements in Pao
2/Fio
2 ratio in both the iloprost and epoprostenol group. Patients in the epoprostenol group appeared to have a higher 90-day mortality compared with the iloprost group. However, our study was not powered to detect a mortality difference and this finding likely represents a sicker population in the epoprostenol group and prescription bias. The use of iloprost was associated with higher vasopressor requirements in the first 12 hours of administration, an association was not observed in the epoprostenol group.

CONCLUSIONS AND RELEVANCE:
In this retrospective cohort analysis, use of both pulmonary vasodilators was associated with similar improvement in gas exchange. The mortality difference observed likely represents difference in severity of illness. Further studies are needed to corroborate these findings.
An Unusual Case of BSND Gene–Related (Type IV) Bartter Syndrome Presenting as Antenatal Bartter Syndrome: A Case Report and Review of Literature
Authors: Shajan Aleena M. , Kumar Manish , Navaneethan Preethi , Danda Sumita , Beck Manisha M. 
Published: January 2023

Abstract
Bartter syndrome is a group of autosomal recessive renal tubular disorders; it has two types of presentation: antenatal and classic. The antenatal type presents as severe unexplained polyhydramnios in the second trimester. This is due to fetal urinary losses of sodium, chloride, and potassium, leading to fetal polyuria. The classic type presents in the late neonatal or infancy stage, with dehydration, dyselectrolytemia, failure to thrive, and nephrocalcinosis. Antenatal scans are normal in such cases. Type I and II Bartter syndrome presents in the antenatal period, whereas type IV has a classic presentation. We describe an unusual case of type IVa Bartter syndrome presenting in the antenatal period, with severe polyhydramnios. The initial diagnosis was made based on amniotic fluid chloride levels and later confirmed by performing a genetic test. Genetic testing is important for confirming diagnosis and prognostication regarding the condition.
Pharmacokinetic-Interactions of BI 425809, a Novel Glycine Transporter 1 Inhibitor, With Cytochrome P450 and P-Glycoprotein Substrates
Authors: Desch Michael , Schlecker Christina , Hohl Kathrin , Liesenfeld Karl-Heinz , Chan Tom , Müller Fabian , Wunderlich Glen , Keller Sascha , Ishiguro Naoki , Wind Sven 
Published: January 2023

Abstract

Purpose/Background
Glycine transporter-1 inhibitors may ameliorate cognitive deficits in schizophrenia. This study evaluated potential drug-drug interactions with the glycine transporter-1 inhibitor BI 425809.

Methods/Procedures
Interactions with cytochromes P450 (CYP) and P-glycoprotein (P-gp) were assessed in in vitro assays using human hepatocytes and Caco-2 cells, respectively. Pharmacokinetic characteristics of probe drugs were subsequently assessed in a Phase I, open-label, single-sequence crossover study in healthy male participants. Participants received a probe-drug cocktail containing midazolam (CYP3A4), warfarin (CYP2C9), and omeprazole (CYP2C19) and a separate dose of digoxin (P-gp), alone and on a background of steady-state BI 425809 25 mg once daily in 2 treatment periods. Adverse events were monitored.

Findings/Results
In vitro assays revealed concentration-dependent induction of CYP3A4 and inhibition of P-gp by BI 425809. In the clinical study, 12 of 13 participants completed both periods. With BI 425809, area under the plasma concentration curve from administration to the last measurement (AUC0–tz) and maximum plasma concentration (C
max) for midazolam were lower than when administered alone. Adjusted geometric mean ratios (90% confidence interval) were 70.6% (63.9%–78.1%) for AUC0–tz and 77.6% (67.3%–89.4%) for C
max. For warfarin and digoxin, AUC0–tz and C
max were similar with and without BI 425809. For omeprazole, BI 425809 slightly reduced AUC0–tz but not C
max versus omeprazole alone. No new safety signals were identified.

Implications/Conclusions
These findings indicate induction of CYP3A4 by once-daily BI 425809 25 mg (the assumed highest therapeutic dose) and no meaningful effects on CYP2C9, CYP2C19, or P-gp in vivo.
Integrative medicine (East Asian herbal medicine combined with conventional medicine) for psoriasis: A protocol for systematic review and meta-analysis
Authors: Kim Hyehwa , Jo Hee-Geun , Hwang Ji-Hye , Lee Donghun 
Published: January 2023

Background:Psoriasis is a chronic, inflammatory, autoimmune skin disease. The aim of this review is to systematically evaluate the efficacy and safety of integrative medicine (East Asian herbal medicine combined with conventional medicine) used to treat inflammatory skin lesions of psoriasis.Methods:A comprehensive literature search will be conducted in 3 English databases (PubMed, Cochrane Library, and Embase), 4 Korean databases (Korean Studies Information Service System, Research Information Service System, Oriental Medicine Advanced Searching Integrated System, and Korea Citation Index), 2 Chinese databases (Chinese National Knowledge Infrastructure Database and Wanfang data), and 1 Japanese database (Citation Information by National Institute of Informatics) for randomized controlled trials from their inception until July 29, 2021. Statistical analysis will be performed usingRversion 4.1.2 and the R studio program using the default settings of the “meta” and “metafor” packages. The primary outcome will be an improvement in the psoriasis area severity index. All outcomes will be analyzed using a random-effects model to produce more statistically conservative results. If heterogeneity is detected in the study, the cause will be identified through sensitivity, meta-regression, and subgroup analyses. Methodological quality will be assessed independently using the revised tool for the risk of bias in randomized trials, version 2.0. The overall quality of evidence will be evaluated according to the Grading of Recommendations Assessment, Development, and Evaluation pro framework.Results:This study will review all available trials on the same subject and arrive at a more statistically robust conclusion based on a sufficient sample size of participants and additional analysis using data mining techniques will be performed on intervention prescription information in clinical studies collected according to rigorous criteria.Conclusion:We believe that this study will provide useful knowledge on managing inflammatory skin lesions of psoriasis vulgaris using integrative medicine using East Asian herbal medicine.
High-frequency plasma exchange therapy for immunocompromised, type I crescentic glomerulonephritis complicated with IgA nephropathy: A case report and literature review
Authors: Chen Huihui , Jin Jingjing , Cheng Mei Juan , He Lei , Zhou Wei , Guo Liping , Niu Zhe Zhe , Liang Xiang Nan , Zhu Rong Fang , Bai Yaling , Xu Jin Sheng 
Published: January 2023

Rationale:
Anti-glomerular basement membrane (anti-GBM) disease has been reported to coexist with other immune-mediated glomerular disorders, including antineutrophil cytoplasmic autoantibody positive glomerulonephritis and membranous glomerulopathy. It is well known that anti-GBM disease often manifests as type I crescentic glomerulonephritis on renal biopsy. However, concurrent cases of both type I crescentic glomerulonephritis and IgA nephropathy are rare.

Patient concerns:
We report the case of a 40-years-old woman with microscopic hematuria, mild proteinuria and an immunocompromised status. Laboratory data revealed serum creatinine showed progressive progress, suddenly rising from the normal range to 316.2μmol/L within 4 months. The CD4 lymphocyte count was 0.274 × 109/L (reference value 0.35–1.82 × 109/L). The anti-GBM antibody titer was 192.4 IU/mL (reference range: <20 RU/mL).

Diagnoses:
Renal biopsy was performed after admission. The pathological diagnosis was type I crescentic glomerulonephritis, IgA nephropathy, and clinical anti-GBM disease.

Interventions:
The patient was seriously ill on admission and progressed rapidly. Combined with poor immune function, we immediately initiated high-frequency plasma exchange (PE). In addition, to avoid rebound of antibody levels, PE was performed for 5 times. Follow-up treatment was combined with standard-dose corticosteroids and cyclophosphamide.

Outcomes:
The patient was followed up for 1 year. On the last visit, her serum creatinine decreased to 103.5μmol/L, anti-GBM antibody remained negative, and proteinuria and hematuria disappeared.

Lessons:
This case illustrates that when crescentic nephritis or anti-GBM disease is combined with other immune diseases, especially when the immune function is extremely low, if the application of high-dose steroid shocks may induce fatal infections, to some extent high frequency PE has certain advantages.
“Repeated LTA injection at low concentration induces capsular contracture by activating adaptive immune response through IL-6/STAT3 signaling pathway”
Authors: Xuan Tianfan , Yuan Xin , Zheng Shaoluan , Wang Lu , Wang Qiang , Zhang Simin , Qi Fazhi , Luan Wenjie 
Published: January 2023

Back ground:
Capsular contracture was the most common complication of breast implantation surgery. Bacterial contamination was considered to play an important role in the occurrence of capsular contracture, and Gram-positive bacteria like Staphylococcus epidermidis were discovered in the clinical specimens. Lipoteichoic acid (LTA) was a component of Gram-positive bacteria cell wall, and was sufficient in the pathogenicity of the bacteria. We assumed that LTA could trigger the immunological response against the implant and cause capsular contracture.

Methods:
We developed a rat model of capsular contracture by repeated injection of 10 μg/ml LTA. The histological changes of the capsule tissue were measured by HE, Sirius Red, Masson and Immunohistochemical staining. The expression of related cytokines was measured by qRT-PCR. The downstream pathway activation was shown by Western blot. We also applied Tocilizumab, an IL-6 receptor antagonist, to verify the role of IL-6 in this pathological process.

Results:
We discovered that repeated LTA injection, at a low concentration, could induce the thickening of capsule tissue, the deposition of collagen fiber and the activation of myofibroblasts. IL-6/STAT3 signaling pathway was activated in this process, and the inhibition of IL-6 receptor could relieve the symptoms. B cells and T-helper cells, especially T-helper 1, could be related to this phenomenon.

Conclusions:
Our research corroborated that subclinical infection could trigger capsular contracture, and the immune system played an important role in this process. Our results provided a possible research direction for the mechanism of bacterial infection-induced immune response against breast implants.