bluuebunny/crossref_metadata_2025_split huggingface dataset:
Respiratory modulations of cortical excitability and interictal spike timing in focal epilepsy - a case report
Authors: Kluger Daniel S. , Erdbrügger Tim , Stier Christina , Höltershinken Malte B. , Abbasi Omid , Saltafossi Martina , Unnwongse Kanjana , Wehner Tim , Wellmer Jörg , Gross Joachim , Wolters Carsten H. 
Published: August 2023

SummaryBrain activity in focal epilepsy is marked by a pronounced excitation-inhibition (E:I) imbalance and interictal epileptiform discharges (IEDs) observed in periods between recurrent seizures. As a marker of E:I balance, aperiodic neural activity and its underlying 1/f characteristic reflect the dynamic interplay of excitatory and inhibitory currents. Recent studies have independently assessed 1/f changes both in epilepsy and in the context of body-brain interactions in neurotypical individuals where the respiratory rhythm has emerged as a potential modulator of excitability states in the brain. Here, we investigate respiration phase-locked modulations of E:I balance and their involvement in the timing of spike discharges in a case report of a 25 year-old focal epilepsy patient using magnetoencephalography (MEG). We show that i) respiration differentially modulates E:I balance in focal epilepsy compared to N = 40 neurotypical controls and ii) IED timing depends on both excitability and respiratory states. These findings overall suggest an intricate interplay of respiration phase-locked changes in excitation and the consequential susceptibility for IED generation and we hope they will spark interest in subsequent work on body-brain coupling and E:I balance in epilepsy.
Ccr4-Not ubiquitin ligase signaling regulates ribosomal protein homeostasis and inhibits 40S ribosomal autophagy
Authors: Johnson Daniel L. , Kumar Ravinder , Kakhniashvili David , Pfeffer Lawrence M. , Laribee R. Nicholas 
Published: August 2023

ABSTRACTThe Ccr4-Not complex containing the Not4 ubiquitin ligase regulates gene transcription and mRNA decay, yet it also has poorly defined roles in translation, proteostasis, and endolysosomal-dependent nutrient signaling. To define how Ccr4-Not mediated ubiquitin signaling regulates these additional processes, we performed quantitative proteomics in the yeastSaccharomyces cerevisiaelacking the Not4 ubiquitin ligase, and also in cells overexpressing either wild-type or functionally inactive ligase. Herein, we provide evidence that both increased and decreased Ccr4-Not ubiquitin signaling disrupts ribosomal protein (RP) homeostasis independently of reduced RP mRNA changes or reductions in known Not4 ribosomal substrates. Surprisingly, we also find that both Not4-mediated ubiquitin signaling, and the Ccr4 subunit, actively inhibit 40S ribosomal autophagy. This 40S autophagy is independent of canonical Atg7-dependent macroautophagy, thus indicating microautophagy activation is responsible. Furthermore, the Not4 ligase genetically interacts with endolysosomal pathway effectors to control both RP expression and 40S autophagy efficiency. Overall, we demonstrate that balanced Ccr4-Not ligase activity maintains RP homeostasis, and that Ccr4-Not ubiquitin signaling interacts with the endolysosomal pathway to both regulate RP expression and inhibit 40S ribosomal autophagy.
Kinetic evidence for multiple aggregation pathways in antibody light chain variable domains
Authors: Wong Sherry , West Madeline E. , Morgan Gareth J. 
Published: August 2023

ABSTRACTAggregation of antibody light chain proteins is associated with the progressive disease light chain amyloidosis. Patient-derived amyloid fibrils are formed from light chain variable domain residues in non-native conformations, highlighting a requirement that light chains unfold from their native structures in order to aggregate. However, mechanistic studies of amyloid formation have primarily focused on the self-assembly of natively unstructured peptides, and the role of native state unfolding is less well understood. Using a well-studied light chain variable domain protein known as WIL, which readily aggregatesin vitrounder conditions where the native state predominates, we asked how the protein concentration and addition of pre-formed fibril “seeds” alter the kinetics of aggregation. Monitoring aggregation with thioflavin T fluorescence revealed a distinctly non-linear dependence on concentration, with a maximum aggregation rate observed at 8 µM protein. This behavior is consistent with formation of alternate aggregate structures in the early phases of amyloid formation. Addition of N- or C-terminal peptide tags, which did not greatly affect the folding or stability of the protein, altered the concentration dependence of aggregation. Aggregation rates increased in the presence of pre-formed seeds, but this effect did not eliminate the delay before aggregation and became saturated when the proportion of seeds added was greater than 1 in 1600. The complexity of aggregation observedin vitrohighlights how multiple species may contribute to amyloid pathology in patients.
Influenza A Virus Infections Sense Host Membrane Tension to Dynamically Tune Assembly
Authors: Partlow Edward A. , Jaeggi-Wong Anna , Planitzer Steven D. , Berg Nick , Li Zhenyu , Ivanovic Tijana 
Published: August 2023

SummaryEnveloped viruses often exhibit a pleomorphic morphology, ranging in size from 100nm spheres to tens-of-micron long filaments. For influenza A virus (IAV), spheres enable rapid replication and minimize metabolic cost, while filaments resist effects of antibodies or other cell-entry pressures. The current paradigm is that virion shape changes require genetic adaptation; however, a virus evolved to alter its shape phenotypically would outperform one that relies on genetic selection. Using a novel quantitative flow virometry assay to characterize virion shape dynamics we find that IAV rapidly tunes its shape distribution to favor spheres under optimal, and filaments under attenuating conditions including the presence of antibodies. We identify membrane tension as a key cue sensed by IAV determining shape distributions. This phenotypic shift outpaces genetic change and serves to enable additional life cycles under pressure. Our work expands knowledge of the complex host-virus interplay to include viral responses to the local environment by optimizing its structure to maximize replication and ultimately host-host transmission.
Zebrafish Drug Screening Identifies Erlotinib as an Inhibitor of Wnt/β-Catenin Signaling and Self-Renewal in T-cell Acute Lymphoblastic Leukemia
Authors: Al-Hamaly Majd A. , Cox Anna H. , Haney Meghan G. , Zhang Wen , Arvin Emma C. , Sampathi Shilpa , Wimsett Mary , Liu Chunming , Blackburn Jessica S. 
Published: August 2023

AbstractThe Wnt/β-catenin pathway’s significance in cancer initiation, progression, and stem cell biology underscores its therapeutic potential, yet clinical application of Wnt inhibitors remains limited due to challenges posed by off-target effects and complex crosstalk with other pathways. In this study, we leveraged the zebrafish model to perform a robust and rapid drug screening of 773 FDA-approved compounds to identify Wnt/β-catenin inhibitors with minimal toxicity. Utilizing zebrafish expressing a Wnt reporter, we identified several drugs that suppressed Wnt signaling without compromising zebrafish development. The efficacy of the top hit, Erlotinib, extended to human cells, where it blocked Wnt/β-catenin signaling downstream of the destruction complex. Notably, Erlotinib treatment reduced self-renewal in human T-cell Acute Lymphoblastic Leukemia cells, which are known to rely on active β-catenin signaling for maintenance of leukemia-initiating cells. Erlotinib also reduced leukemia-initiating cell frequency and delayed disease formation in zebrafish models. This study underscores zebrafish’s translational potential in drug discovery and repurposing, and highlights a new use for Erlotinib as a Wnt inhibitor for cancers driven by aberrant Wnt/β-catenin signaling.HighlightsZebrafish-based drug screening offers an inexpensive and robust platform for identifying compounds with high efficacy and low toxicityin vivo.Erlotinib, an Epidermal Growth Factor Receptor (EGFR) inhibitor, emerged as a potent and promising Wnt inhibitor with effects in both zebrafish and human cell-based Wnt reporter assays.The identification of Erlotinib as a Wnt inhibitor underscores the value of repurposed drugs in developing targeted therapies to disrupt cancer stemness and improve clinical outcomesGraphical Abstract
Accounting and racial violence in the postbellum American South
Authors: Walker Stephen P. 
Published: August 2023

PurposeThe paper aims to explore the relationship between accounting and racial violence through an investigation of sharecropping in the postbellum American South.Design/methodology/approachA range of primary sources including peonage case files of the US Department of Justice and the archives of the National Association for the Advancement of Colored People (NAACP) are utilised. Data are analysed by reference to Randall Collins' theory of violence. Consistent with this theory, a micro-sociological approach to examining violent encounters is employed.FindingsIt is demonstrated that the production of alternative or competing accounts, accounting manipulation and failure to account generated interactions where confrontational tension culminated in bluster, physical attacks and lynching. Such violence took place in the context of potent racial ideologies and institutions.Originality/valueThe paper is distinctive in its focus on the interface between accounting and “actual” (as opposed to symbolic) violence. It reveals how accounting processes and traces featured in the highly charged emotional fields from which physical violence could erupt. The study advances knowledge of the role of accounting in race relations from the late nineteenth century to the mid-twentieth century, a largely unexplored period in the accounting history literature. It also seeks to extend the research agenda on accounting and slavery (which has hitherto emphasised chattel slavery) to encompass the practice of debt peonage.
Gender and decision-making styles in male and female managers of Chilean SMEs
Authors: Inostroza M.A. , Sepúlveda Velásquez Jorge , Ortúzar Santiago 
Published: August 2023

PurposeThis article aims to analyze how gender and decision-making styles of Chief Executive Officers (CEOs) of Small and Medium Enterprises (SMEs) impact the financial performance of the firms they manage.Design/methodology/approachData were obtained for 2017 for 185 SMEs in Chile, an emerging economy, including firm information, CEO's sociodemographic characteristics and CEOs' decision-making styles. Generalized Least Squares (GLS) models were estimated to explain the influence of gender and decision-making styles on firm performance, controlling for a series of covariates. To test whether gender moderates the effect of decision-making styles on firm performance, interaction terms were included. Furthermore, models were subject to several robustness procedures, with no significant differences in results.FindingsThe authors find evidence of significant relationships for both gender and the avoidant style. Likewise, the authors find evidence of interaction effects between gender and decision-making styles, particularly between gender and the dependent style.Originality/valueFindings contribute to prior research by analyzing the relationship between CEO gender and SME performance in the context of a Latin American emerging economy; by providing evidence of the impact of decision-making styles on the financial performance of SMEs; and by examining how a specific decision-making style, namely the dependent style, operates differently according to CEO gender, shedding some light on its ambiguous character as described by prior research. For policymakers and authorities, findings indicate the importance of incorporating women to SMEs and supporting their way towards higher management.
A network data envelopment analysis based paradigm to benchmark fiscal performance – an analysis of fiscal outlay efficiency among Indian states
Authors: Arora Nitin , Talwar Shubhendra Jit 
Published: August 2023

PurposeThe fiscal outlay efficiency matters when the performance-based allocation of funds is made to state governments by the central government in a federal structure of an economy like India. Also the efficiency cannon of public expenditure is a key aspect in the field of public economics. Thus, a study to evaluate the efficiency in fiscal outlay of Indian states has been conducted.Design/methodology/approachThe paper offers a three divisions–based paradigm under Network Data Envelopment Analysis framework to compare the performance of fiscal entities (say Indian state governments) in converting available fiscal resources into desired short-run and long-run growth and development objectives. The network efficiency score has been taken as a measure of the quality of fiscal outlay management that is trifurcated into divisional efficiencies representing budgeting process, fiscal outlay efficiency process and fiscal outlay effectiveness process.FindingsIt has been noticed that the states are under performing in achieving short-run growth targets and so the efficiency process division has been identified a major source of fiscal under performance. Suboptimum allocation of fiscal expenditure under various heads within the fiscal resources, as explained under budgeting process, is another major cause of fiscal under performance.Practical implicationsThe study purposes a three divisions–based paradigm that takes into account efficiency of a state in (1) planning budget, (2) achieving short-run growth targets and (3) achieving long-run development targets. These three stages are named as budgeting process efficiency, fiscal outlay efficiency and fiscal outlay effectiveness, respectively. Therefore, a new paradigm called BEE paradigm is proposed to evaluate performance of fiscal entities in terms of fiscal outlay efficiency.Originality/valueIn existing literature on measuring efficiency of public expenditure, the public sector outputs have been made as function of fiscal expenditure as input treating the said outlay as an exogenous variable. In present context, the fiscal expenditure has been treated endogenous to the budgeting process. A high inefficiency on account of budgeting process supports this treatment too.
Green product development framework: empirical evidence from Chinese automotive supply chains
Authors: Abdulrahman Muhammad Dan-Asabe , Subramanian Nachiappan 
Published: August 2023

PurposeThe study aims to develop and test a supply chain wide green product development framework of focal firms and their major suppliers, in the context of the Chinese automotive industry.Design/methodology/approachAn in-depth case studies approach is adopted for this study. Three automotive sector upstream supply chains involving 17 firms and 51 experts as respondents were interviewed on the importance and implementation effectiveness of 6Rs (reduce, redesign, recover, remanufacture, reuse and recycle) across the manufacturer and their respective tier 1 and tier 2 suppliers.FindingsThe results indicate that the Chinese automotive sector supply chains are mainly focused on “reduce” practices with immediate environmental and economic benefits. The investigated firms however had future implementation plans for “redesign” and “recovery” practices to become comprehensive in green product development (GPD).Research limitations/implicationsThe study facilitates automotive firms, industry policymakers and researchers the understanding of incorporating comprehensive GSCM practices across the upstream supply chain to achieve circularity. The study focused on upstream supply chain due to the concentration of major production practices in this section of the supply chain. However, the downstream supply chain equally deserve attention as well as the need to understand the mediating and moderating roles of the different Rs to tease out the pros and cons of achieving overall environmental sustainability.Originality/valueThere are very limited studies on comprehensive GPD for achieving optimal GSCM and sustainability. By simultaneous looking at a focal firm and its upstream supply chains GSCM practices, this study addresses a system-wide comprehensive GPD issues from implementation of 6Rs perspectives in the supply chain.
Unveiling the link between operational interdependency and supply chain performance
Authors: Yang Jie , Xie Hongming , Wang Yuan 
Published: August 2023

PurposeThis study investigates the possible curvilinear relationship between operational interdependency and supply chain performance as well as the contingency effect of supply chain disruptions, in terms of disruption orientation and disruption impact.Design/methodology/approachPath analysis was employed to test the hypotheses using the data collected from Chinese manufacturers.FindingsThe results confirm an inverted U-shape effect of operational interdependency. As level of buyer-supplier operational dependency increase, the supply chain performance is enhanced. However, the benefits of operational interdependency diminish beyond a certain point. Additionally, the findings of this study show the disruption orientations positively moderate the relationship between interdependency and performance, whereas the effect of disruption impact is not significant.Originality/valueThe findings of this study provide an explanation to the theoretical gap about the equivocal results of the effect of dependency, which provide new insights into the literature regarding buyer-supplier relationships. Furthermore, this paper identifies the moderating role of supply chain disruption in the relationship between operational interdependency and supply chain performance, which provide further explanation about the mixed results of the effect of dependency. The results confirmed that supply chain disruption orientation positively moderate the relationship between operational interdependency and supply chain performance.
Ecological resource deficits as opportunities for environmental innovation across countries
Authors: Battisti Martina , Huang Shuangfa , Pickernell David 
Published: August 2023

PurposeWhile previous research has identified that environmental innovation is shaped by a variety of drivers, researchers have devoted limited attention to the role of nature-based resources in the country. Building on environmental innovation theory and the natural resource-based view of the firm, this study introduces ecological resource deficits as a novel driver of environmental innovation. The authors explore how ecological resource deficits interact with institutional and regulatory drivers as well as firm-level technology drivers to explain the extent of environmental innovation across different countries.Design/methodology/approachThe authors apply fuzzy-set qualitative comparative analysis to a multi-source dataset to identify different pathways for environmental innovation across 28 countries.FindingsFindings show that higher environmental innovation is a function of ecological resource deficits complemented by the presence of at least two other conditions. Moreover, the results show that environmental policy stringency and societal expectations are substitute conditions of environmental innovation.Originality/valueThis study reveals the interdependences between different conditions for environmental innovation across countries contributing to a more nuanced understanding of the geography of environmental innovation.
Social media sites and nightlife tourism: an empirical study of tourist decision-making on nightlife entertainment consumption
Authors: Phucharoen Chayanon , Wichupankul Surarak , Sangkaew Nichapat , Stosic Kristina 
Published: August 2023

Purpose
This paper aims to investigate the effect of tourists’ social media usage when planning trips on the probability of tourists consuming nightlife activities and their spending on nightlife consumption.

Design/methodology/approach
Two thousand questionnaires comprising questions about social media usage, consumption of nightlife entertainment and decisions to consume nightlife activities are distributed to international visitors at the departure hall of Phuket International Airport. A series of regressions are estimated. A Heckman two-step correction model is conducted to avoid the potential of selection bias.

Findings
Results show that the information available on Facebook positively links with the probability of tourists consuming nightlife activities. Furthermore, findings indicate that the usage of YouTube in tourist trip planning could statistically influence tourists to spend more on their nightlife consumption. Therefore, the results suggest that entrepreneurs could use Facebook to stimulate tourists’ nightlife consumption, while YouTube could be used to elevate tourists’ spending on nightlife consumption. The influence of these two social media sites on tourists’ decisions aids the authorities in the mitigation of the negative impacts of nightlife tourism.

Originality/value
Given the increasing role of social media in tourists’ consumption choices, to the best of the authors’ knowledge, this is the first paper to quantitatively explore the relationship between tourists’ social media usage and nightlife consumption in Thailand. The revealed relationship between the use of specific social media sites (Facebook and YouTube) and tourists’ decisions to consume and the amount spent on nightlife consumption could be used by nightlife tourism entrepreneurs and destination marketers in their marketing campaigns, yielding competitive advantages. Meanwhile, related authorities and non-profit organisations could apply this study’s findings to demarket tourists’ consumption of nightlife activities in areas affected by the negative impacts of tourists’ nightlife consumption.
Handling qualitative conditional preference queries in SPARQL: possibilistic logic approach
Authors: Touazi Faycal , Boustil Amel 
Published: August 2023

Purpose
The purpose of this paper is to address the need for new approaches in locating items that closely match user preference criteria due to the rise in data volume of knowledge bases resulting from Open Data initiatives. Specifically, the paper focuses on evaluating SPARQL qualitative preference queries over user preferences in SPARQL.

Design/methodology/approach
The paper outlines a novel approach for handling SPARQL preference queries by representing preferences through symbolic weights using the possibilistic logic (PL) framework. This approach allows for the management of symbolic weights without relying on numerical values, using a partial ordering system instead. The paper compares this approach with numerous other approaches, including those based on skylines, fuzzy sets and conditional preference networks.

Findings
The paper highlights the advantages of the proposed approach, which enables the representation of preference criteria through symbolic weights and qualitative considerations. This approach offers a more intuitive way to convey preferences and manage rankings.

Originality/value
The paper demonstrates the usefulness and originality of the proposed SPARQL language in the PL framework. The approach extends SPARQL by incorporating symbolic weights and qualitative preferences.