bluuebunny/crossref_metadata_2025_split huggingface dataset:
THE INFLUENCE OF LEVEL CROSSINGS ON ECONOMIC GROWTH AND SOCIAL DYNAMICS IN CIREBON CITY
Authors: Novriani Shinta , Hariani Mira Lestira , Rohman Fathur 
Published: August 2023

Cirebon City is one of the metropolitan areas stipulated in PP No. 26 of 2008 namely RTRWN as a National Activity Center (PKN) in developing metropolitan areas, especially in Ciayumajakuning area. The Cirebon City has become the center of economic growth, resulting in an increase in the flow of urbanization and in line with social dynamics that must be considered due to urban city activities. One of the impacts of urban cities is the increase in traffic density, causing a decrease in traffic performance. The purpose of this study is to determine the existing conditions of railroad level crossings in Cirebon City and see their impact on traffic performance, social dynamics and economic growth in Cirebon City. The research method used is a survey method, including traffic volume surveys, train frequency surveys, and calculating queue lengths and calculating delays. Based on the result of a survey on 8 roads in the Cirebon City with an average capacity of 3191 smp/hour, the degree of saturation is 0.5, the Level of Service value is C, which means the flow is stable, the speed can be controlled by traffic. However, if it is review based on an economic analysis related to the loss of community income due to level crossings if it is assumed that the average income of the people of Cirebon City is IDR 2.304.943.51 each individual experiences losses ranging from IDR 0 – IDR 768.314 for one month depending on the how long the individual experiences waiting time at a level crossing. If analyzed based on fuel consumption, each individual experiences a loss of IDR 0 – IDR 30.294 per month depending on the waiting time and the type of fuel used and if it is associated with the economic growth of Cirebon City, it is expected to increase the contribution of GRDP for each sector and respondents feel that level crossing are very important affect their travel interest.
Student Engagement in Online Learning Among Undergraduate Nursing Students
Authors: Sugiharto Firman , Hara Permana Ryan , Hermayanti Yanti 
Published: August 2023

Aims: Student engagement (SE) is a significant factor for success in online learning. The low of SE will impact students' academic achievement.
Purpose: This study aimed to describe SE in online learning at the Faculty of Nursing, Universitas Padjadjaran.
Methods: This study was quantitative descriptive research. The population was undergraduate nursing students (N=862). The sample criteria were that respondents were active students of the Faculty of Nursing, Universitas Padjadjaran for the 2020/2021 period from the Jatinangor and Pangandaran campuses. The sampling technique was total sampling with a response rate of 64,3% (n=554). Data were collected using the Online Community and Student Engagement Scale. Data were analyzed using descriptive statistics and presented in frequency distribution tables.
Results: The results showed that more than half of students (52.7%) had a low category of SE, and nearly half (47.3%) have shown a high category of SE in online learning. Students had low levels of Community Building with the Instructor, Community Building with Classmates, and Engagement with Learning (57.4%; 58.3%; and 51.8%, respectively). The SE level that the respondent currently has has the potential to be increased along with the ongoing process during the lecture period.
Conclusion: More than half of students had a low category of SE in online learning this could have a negative impact on student achievement and educational completion rates. Therefore, intense interactions through discussions between students and lecturers, constructive feedback, and motivational support are highly recommended to be provided by the faculty and peers for improving the SE.
Development and validation of a rapid visual technique for left ventricular hypertrophy detection from the electrocardiogram
Authors: Somani Sulaiman , Hughes J. Weston , Ashley Euan A. , Witteles Ronald M. , Perez Marco V. 
Published: August 2023

IntroductionLeft ventricular hypertrophy (LVH) detection techniques on by electrocardiogram (ECG) are cumbersome to remember with modest performance. This study validated a rapid technique for LVH detection and measured its performance against other techniques.MethodsThis was a retrospective cohort study of patients at Stanford Health Care who received ECGs and resting transthoracic echocardiograms (TTE) from 2006 through 2018. The novel technique, Witteles-Somani (WS), assesses for S- and R-wave overlap on adjacent precordial leads. The WS, Sokolow-Lyon, Cornell, and Peguero-Lo Presti techniques were algorithmically implemented on ECGs. Classification metrics, receiver-operator curves, and Pearson correlations measured performance. Age- and sex-adjusted Cox proportional hazard models evaluated associations between incident cardiovascular outcomes and each technique.ResultsA total of 53,333 ECG-TTE pairs from 18,873 patients were identified. Of all ECG-TTE pairs, 21,638 (40.6%) had TTE-diagnosed LVH. The WS technique had a sensitivity of 0.46, specificity of 0.66, and AUROC of 0.56, compared to Sokolow-Lyon (AUROC 0.55), Cornell (AUROC 0.63), and Peguero-Lo Presti (AUROC 0.63). Patients meeting LVH by WS technique had a higher risk of cardiovascular mortality [HR 1.18, 95% CI (1.12, 1.24), P &lt; 0.001] and a higher risk of developing any cardiovascular disease [HR 1.29, 95% CI (1.22, 1.36), P &lt; 0.001], myocardial infarction [HR 1.60, 95% CI (1.44, 1.78), P &lt; 0.005], and heart failure [HR 1.24, 95% CI (1.17, 1.32), P &lt; 0.001].ConclusionsThe WS criteria is a rapid visual technique for LVH detection with performance like other LVH detection techniques and is associated with incident cardiovascular outcomes.
Gene–diet interaction analysis using novel weighted food scores discovers the adipocytokine signaling pathway associated with the development of type 2 diabetes
Authors: Apio Catherine , Chung Wonil , Moon Min Kyong , Kwon Oran , Park Taesung 
Published: August 2023

IntroductionThe influence of dietary patterns measured using Recommended Food Score (RFS) with foods with high amounts of antioxidant nutrients for Type 2 diabetes (T2D) was analyzed. Our analysis aims to find associations between dietary patterns and T2D and conduct a gene-diet interaction analysis related to T2D.MethodsData analyzed in the current study were obtained from the Korean Genome and Epidemiology Study Cohort. The dietary patterns of 46 food items were assessed using a validated food frequency questionnaire. To maximize the predictive power of the RFS, we propose two weighted food scores, namely HisCoM-RFS calculated using the novel Hierarchical Structural Component model (HisCoM) and PLSDA-RFS calculated using Partial Least Squares-Discriminant Analysis (PLS-DA) method.ResultsBoth RFS (OR: 1.11; 95% CI: 1.03- 1.20; P = 0.009) and PLSDA-RFS (OR: 1.10; 95% CI: 1.02-1.19, P = 0.011) were positively associated with T2D. Mapping of SNPs (P &lt; 0.05) from the interaction analysis between SNPs and the food scores to genes and pathways yielded some 12 genes (CACNA2D3, RELN, DOCK2, SLIT3, CTNNA2, etc.) and pathways associated with T2D. The strongest association was observed with the adipocytokine signalling pathway, highlighting 32 genes (STAT3, MAPK10, MAPK8, IRS1, AKT1-3, ADIPOR2, etc.) most likely associated with T2D. Finally, the group of the subjects in low, intermediate and high using both the food scores and a polygenic risk score found an association between diet quality groups with issues at high genetic risk of T2D.ConclusionA dietary pattern of poor amounts of antioxidant nutrients is associated with the risk of T2D, and diet affects pathway mechanisms involved in developing T2D.
Lessons from clinical implementation of a preemptive pharmacogenetic panel as part of a testing pilot program with an employer-sponsored medical plan
Authors: Norris Madeline , Dalton Rachel , Alam Benish , Eddy Elizabeth , Nguyen Khoa A. , Cavallari Larisa H. , Sumfest Jill , Wiisanen Kristin , Cicali Emily J. 
Published: August 2023

Introduction: This manuscript reports on a pilot program focused on implementing pharmacogenetic testing within the framework of an employer-sponsored medical plan at University of Florida (UF) Health. The aim was to understand the challenges associated with program implementation and to gather insights into patient attitudes towards PGx testing.Methods: The pilot program adopted a partially preemptive approach, targeting patients on current prescriptions for medications with relevant gene-drug associations. Patients were contacted via phone or through the MyChart system and offered pharmacogenetic testing with no additional direct costs.Results: Of 244 eligible patients, 110 agreed to participate. However, only 61 returned the mailed DNA collection kits. Among these, 89% had at least one potentially actionable genotype-based phenotype. Post-test follow-up revealed that while the majority viewed the process positively, 71% preferred a consultation with a pharmacogenetic specialist for better understanding of their results. Barriers to implementation ranged from fatigue with the healthcare system to a lack of understanding of the pharmacogenetic testing and concerns about privacy and potential misuse of genetic data.Conclusion: The findings underscore the need for clearer patient education on pharmacogenetic results and suggest the importance of the role of pharmacogenetic-trained pharmacists in delivering this education. They also highlight issues with relying on incomplete or inaccurate medication lists in patients’ electronic health record. The implementation revealed less obvious challenges, the understanding of which could be beneficial for the success of future preemptive pharmacogenetic implementation programs. The insights from the pilot program served to bridge the information gap between patients, providers, and pharmacogenetic -specialists, with the ultimate goal of improving patient care.
Based on disulfidptosis-related glycolytic genes to construct a signature for predicting prognosis and immune infiltration analysis of hepatocellular carcinoma
Authors: Wang Zhijian , Chen Xuenuo , Zhang Jia , Chen Xuanxin , Peng Jiayi , Huang Wenxiang 
Published: August 2023

BackgroundHepatocellular carcinoma (HCC) comprises several distinct molecular subtypes with varying prognostic implications. However, a comprehensive analysis of a prognostic signature for HCC based on molecular subtypes related to disulfidptosis and glycolysis, as well as associated metabolomics and the immune microenvironment, is yet to be fully explored.MethodsBased on the differences in the expression of disulfide-related glycolytic genes (DRGGs), patients with HCC were divided into different subtypes by consensus clustering. Establish and verify a risk prognosis signature. Finally, the expression level of the key gene SLCO1B1 in the signature was evaluated using immunohistochemistry (IHC) and quantitative real-time PCR (qRT-PCR) in HCC. The association between this gene and immune cells was explored using multiplex immunofluorescence. The biological functions of the cell counting kit-8, wound healing, and colony formation assays were studied.ResultsDifferent subtypes of patients have specific clinicopathological features, prognosis and immune microenvironment. We identified seven valuable genes and constructed a risk-prognosis signature. Analysis of the risk score revealed that compared to the high-risk group, the low-risk group had a better prognosis, higher immune scores, and more abundant immune-related pathways, consistent with the tumor subtypes. Furthermore, IHC and qRT-PCR analyses showed decreased expression of SLCO1B1 in HCC tissues. Functional experiments revealed that SLCO1B1 overexpression inhibited the proliferation, migration, and invasion of HCC cells.ConclusionWe developed a prognostic signature that can assist clinicians in predicting the overall survival of patients with HCC and provides a reference value for targeted therapy.
Study on the growth mechanism of the internal oxide layer in 9% Ni cryogenic steel
Authors: Du Hegang , Sun Haoran , Cai Minghui , Zuo Xiurong 
Published: August 2023

The oxidation behavior of the Ni-rich layer in the internal oxide layer (IOL) in 9% Ni cryogenic steel is investigated at 1,150°C for 0–240 min in the air atmosphere. The morphology and phase composition of the Ni—rich layer are analyzed with energy dispersive spectroscopy, scanning electron microscopy, metallographic microscopy, and X—ray diffraction. The results show that the Ni—rich layer mainly consists of gray Fe3O4/FeO and white Ni–Fe particles, with a small amount of black Fe2SiO4. The morphologies of Ni–Fe particles undergo the following changes with isothermal oxidation time: dot—like → strip—like → net-like; at the same time, layered Ni–Fe particles were formed at about 1/3 of the thickness of the Ni—rich layer. Compared with the dot-like Ni–Fe particle, the net-like and layered Ni–Fe particles provide a fast path for the diffusion of O in the Ni—rich layer. However, the experimental steel still has a much lower oxidation rate because of the hindrance of Ni–Fe particles on the out-diffusion of Fe. During the oxidation process, the Kirkendall effect induces pores/cavities in the IOL, which weakens the stability of the IOL. In the end, the spalling phenomenon of the layered Ni–Fe particle occurs at 1,150°C for 180 min.
Microbleed clustering in thalamus sign in CADASIL patients with NOTCH3 R75P mutation
Authors: Takei Jun , Higuchi Yujiro , Ando Masahiro , Yoshimura Akiko , Yuan Jun-Hui , Fujisaki Natsumi , Tokashiki Takashi , Kanzato Naomi , Jonosono Manabu , Sueyoshi Takeshi , Kanda Naoaki , Matsuoka Hideki , Okubo Ryuichi , Suehara Masahito , Matsuura Eiji , Takashima Hiroshi 
Published: August 2023

Background and objectiveCerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is an inherited cerebral microvascular disease characterized by the development of vascular dementia and lacunar infarctions. This study aimed to identify the genetic and clinical features of CADASIL in Japan.MethodsWe conducted genetic analysis on a case series of patients clinically diagnosed with CADASIL. Clinical and imaging analyses were performed on 32 patients with pathogenic mutations in the NOTCH3 gene. To assess the presence of cerebral microbleeds (CMBs), we utilized several established rating scales including the Fazekas scale, Scheltens rating scale, and Microbleed Anatomical Rating Scale, based on brain MRI images.ResultsAmong the 32 CADASIL patients, 24 cases were found carrying the R75P mutation in NOTCH3, whereas the remaining eight cases had other NOTCH3 mutations (R75Q, R110C, C134F, C144F, R169C, and R607C). The haplotype analysis of the R75P mutation uncovered the presence of a founder effect. A brain MRI analysis revealed that cases with the R75P mutation had a significantly higher total number of CMBs, particularly in the thalamus when compared to patients with other NOTCH3 mutations. Among 15 out of 24 cases with the R75P mutation, we observed a notable clustering of CMBs in the thalamus, termed microbleed clustering in thalamus sign (MCT sign).ConclusionWe propose that the MCT sign observed in NOTCH3 R75P-related CADASIL patients may serve as a potentially characteristic imaging feature. This finding offers further insights into the interactions between genotypes and phenotypes between NOTCH3 and CADASIL.
Botulinum toxin use in patients with post-stroke spasticity: a nationwide retrospective study from France
Authors: Levy Jonathan , Karam Pierre , Forestier Anne , Loze Jean-Yves , Bensmail Djamel 
Published: August 2023

BackgroundCurrent guidelines recommend intramuscular botulinum toxin type A (BoNT-A) injection as first-line treatment for spasticity, a frequent and impairing feature of various central nervous system (CNS) lesions such as stroke. Patients with spasticity commonly require BoNT-A injections once every 3 to 4 months. We conducted a nationwide, population-based, retrospective cohort study, using the French National Hospital Discharge Database (PMSI), to describe BoNT-A use for spasticity in clinical practice in France between 2014 and 2020. The PMSI database covers the whole French population, corresponding to over 66 million persons.MethodsWe first searched the PMSI database for healthcare facility discharge of patients who received BoNT-A injections between 2014 and 2020, corresponding to the first set. For each BoNT-A-treated patient, we identified the medical condition for which BoNT-A may have been indicated. Another search of the PMSI database focused on patients admitted for acute stroke between 2014 and 2016 and their spasticity-related care pathway (second set). Overall, two subpopulations were analysed: 138,481 patients who received BoNT-A injections between 2014 and 2020, and 318,025 patients who survived a stroke event between 2014 and 2016 and were followed up until 2020.ResultsAmong the 138,481 BoNT-A-treated patients, 53.5% received only one or two BoNT-A injections. Most of these patients (N = 85,900; 62.0%) received BoNT-A because they had CNS lesions. The number of patients with CNS lesions who received ≥1 BoNT-A injection increased by a mean of 7.5% per year from 2014 to 2019, but decreased by 0.2% between 2019 and 2020, corresponding to the COVID-19 outbreak. In stroke survivors (N = 318,025), 10.7% were coded with post-stroke spasticity, 2.3% received ≥1 BoNT-A injection between 2014 and 2020, and only 0.8% received ≥3 injections within the 12 months following BoNT-A treatment initiation, i.e., once every 3 to 4 months.ConclusionOur analysis of the exhaustive PMSI database showed a suboptimal implementation of BoNT-A treatment recommendations in France. BoNT-A treatment initiation and re-administration are low, particularly in patients with post-stroke spasticity. Further investigations may help explain this observation, and may target specific actions to improve spasticity-related care pathway.
Multi-phase-combined CECT radiomics models for Fuhrman grade prediction of clear cell renal cell carcinoma
Authors: Zhou Zhiyong , Qian Xusheng , Hu Jisu , Geng Chen , Zhang Yongsheng , Dou Xin , Che Tuanjie , Zhu Jianbing , Dai Yakang 
Published: August 2023

ObjectiveThis study aimed to evaluate the effectiveness of multi-phase-combined contrast-enhanced CT (CECT) radiomics methods for noninvasive Fuhrman grade prediction of clear cell renal cell carcinoma (ccRCC).MethodsA total of 187 patients with four-phase CECT images were retrospectively enrolled and then were categorized into training cohort (n=126) and testing cohort (n=61). All patients were confirmed as ccRCC by histopathological reports. A total of 110 3D classical radiomics features were extracted from each phase of CECT for individual ccRCC lesion, and contrast-enhanced variation features were also calculated as derived radiomics features. These features were concatenated together, and redundant features were removed by Pearson correlation analysis. The discriminative features were selected by minimum redundancy maximum relevance method (mRMR) and then input into a C-support vector classifier to build multi-phase-combined CECT radiomics models. The prediction performance was evaluated by the area under the curve (AUC) of receiver operating characteristic (ROC).ResultsThe multi-phase-combined CECT radiomics model showed the best prediction performance (AUC=0.777) than the single-phase CECT radiomics model (AUC=0.711) in the testing cohort (p value=0.039).ConclusionThe multi-phase-combined CECT radiomics model is a potential effective way to noninvasively predict Fuhrman grade of ccRCC. The concatenation of first-order features and texture features extracted from corticomedullary phase and nephrographic phase are discriminative feature representations.
The impact of staging FDG-PET/CT on treatment for stage III NSCLC - an analysis of population-based data from Ontario, Canada
Authors: Beers Craig A. , Pond Gregory R. , Wright James R. , Tsakiridis Theodoros , Okawara Gordon S. , Swaminath Anand 
Published: August 2023

PurposeFluoro-2-deoxyglucose positron-emission tomography (FDG-PET/CT) is now considered a standard investigation for the staging of new cases of stage III NSCLC. However, there is not published level 3 evidence demonstrating the impact of FDG-PET/CT on appropriate therapy in this setting. Using retrospective population-based data, we sought to examine the role and timing that FDG-PET/CT scans play in influencing treatment choice, as well as survival in patients diagnosed with stage III NSCLC.Materials and methodsA retrospective cohort of patients diagnosed with stage III NSCLC from 2009-2017 in Ontario were identified from the IC/ES (formerly Institute of Clinical Evaluative Sciences) database. FDG-PET/CT utilization over time, trends in mediastinal biopsy technique and usage, the impact of FDG-PET/CT on overall survival (OS), and its influence on use of concurrent chemoradiotherapy (CRT) were explored. The impact of timing of pre-treatment FDG-PET/CT on OS was also analyzed (≤28 days prior to treatment, 29-56 days prior, and &gt;56 days prior).ResultsBetween 2007 and 2017, a total of 13 796 people were diagnosed with stage III NSCLC in Ontario. FDG-PET/CT utilization increased over time with 0% of cases in 2007 and 74% in 2017 with pre-treatment FDG-PET/CT scans. The number of patients who received a mediastinal biopsy similarly increased in this timeframe increasing from 41% to 53%. More patients with pre-treatment FDG-PET/CT scans received curative-intent therapy than those who did not: 23% vs 13% for CRT (p&lt;0.001), and 23% vs 10% for surgery (p&lt;0.001). Median OS was longer in those with FDG-PET/CT scans prior to treatment (17 vs 11 months), as was 5-year survival (22% vs 14%, p&lt;0.001), and this held true on both univariate and multivariate analyses. Timing of FDG-PET/CT scan relative to treatment was not associated with differences in OS.ConclusionImprovements in OS were seen in this cohort of stage III NSCLC patients who underwent a pre-treatment FDG-PET/CT scan. This can likely be attributed to stage-appropriate therapy due to more complete staging using FDG-PET/CT. This study stresses the importance of complete staging for suspected stage III NSCLC using FDG-PET/CT, and a need for continued advocacy for increased access to FDG-PET/CT scans.