bluuebunny/crossref_metadata_2025_split huggingface dataset:
Updated consensus guidelines on the management of Phelan–McDermid syndrome
Authors: Srivastava Siddharth , Sahin Mustafa , Buxbaum Joseph D. , Berry‐Kravis Elizabeth , Soorya Latha Valluripalli , Thurm Audrey , Bernstein Jonathan A. , Asante‐Otoo Afua , Bennett William E. , Betancur Catalina , Brickhouse Tegwyn H. , Passos Bueno Maria Rita , Chopra Maya , Christensen Celanie K. , Cully Jennifer L. , Dies Kira , Friedman Kate , Gummere Brittany , Holder J. Lloyd , Jimenez‐Gomez Andres , Kerins Carolyn A. , Khan Omar , Kohlenberg Teresa , Lacro Ronald V. , Levi Lori A. , Levy Tess , Linnehan Diane , Eva Loth , Moshiree Baharak , Neumeyer Ann , Paul Scott M. , Phelan Katy , Persico Antonio , Rapaport Robert , Rogers Curtis , Saland Jeffrey , Sethuram Swathi , Shapiro Janine , Tarr Phillip I. , White Kerry M. , Wickstrom Jordan , Williams Kent M. , Winrow Dana , Wishart Brian , Kolevzon Alexander 
Published: July 2023

AbstractPhelan–McDermid syndrome (PMS) is a genetic condition caused by SHANK3 haploinsufficiency and characterized by a wide range of neurodevelopmental and systemic manifestations. The first practice parameters for assessment and monitoring in individuals with PMS were published in 2014; recently, knowledge about PMS has grown significantly based on data from longitudinal phenotyping studies and large‐scale genotype–phenotype investigations. The objective of these updated clinical management guidelines was to: (1) reflect the latest in knowledge in PMS and (2) provide guidance for clinicians, researchers, and the general community. A taskforce was established with clinical experts in PMS and representatives from the parent community. Experts joined subgroups based on their areas of specialty, including genetics, neurology, neurodevelopment, gastroenterology, primary care, physiatry, nephrology, endocrinology, cardiology, gynecology, and dentistry. Taskforce members convened regularly between 2021 and 2022 and produced specialty‐specific guidelines based on iterative feedback and discussion. Taskforce leaders then established consensus within their respective specialty group and harmonized the guidelines. The knowledge gained over the past decade allows for improved guidelines to assess and monitor individuals with PMS. Since there is limited evidence specific to PMS, intervention mostly follows general guidelines for treating individuals with developmental disorders. Significant evidence has been amassed to guide the management of comorbid neuropsychiatric conditions in PMS, albeit mainly from caregiver report and the experience of clinical experts. These updated consensus guidelines on the management of PMS represent an advance for the field and will improve care in the community. Several areas for future research are also highlighted and will contribute to subsequent updates with more refined and specific recommendations as new knowledge accumulates.
Optimization through response surface methodology of 3D printed membrane preparation conditions for use in vanadium redox flow battery: A vanadium/proton selectivity study
Authors: Thiam Baye Gueye , El Magri Anouar , Vaudreuil Sébastien 
Published: July 2023

AbstractSPEEK membrane applicable in Vanadium Redox Flow Battery (VRFB) have been 3D printed via Fused Deposition Modeling (FDM). Response Surface Methodology (RSM) has been used to optimize conditions for 3D printing membrane. Good membranes characteristics were obtained by manipulating three parameters, namely the printing temperature, the orientation of the printing layer and the sulfonation time. We evaluated the effects of these three variables on the permeability of membranes to protons and vanadium ions. Results have shown that sulfonation is the most significant variable influencing vanadium and proton permeability. The optimal printing conditions were found at 408°C temperature with a horizontal layer orientation, while the best sulfonation is obtained at 6 min. The optimal membrane has an ion exchange capacity of 0.86 mmolg−1, a water uptake ratio of 22%, a VO2+ permeability of 6.1 × 10−8 cm2 min−1, a H+ permeability of 7.0 × 10−6 cm2 min−1, excellent mechanical stability and better H+/VO2+ perm selectivity than conventional sulfonated polyether ether ketone (SPEEK), Fap450 and Nafion211 membranes. The above results show that the 3D‐SPEEK membrane has great advantages and broad prospects for VRFB applications.
Enhancement of nuclear radiation shielding properties of silicone rubber with γ‐ray irradiation induced graphene oxide modified carbonyl iron powder hybrid fillers
Authors: Sun Xiaoyi , Meng Xianfang , Dai Pei , Xu Riwei , Cheng Anren , Guo Yueying , Jiao Yang , Lu Yongjun , Wang Liancai 
Published: July 2023

AbstractIn this study the graphene oxide modified carbonyl iron (GO‐CI) was prepared by γ‐ray irradiation, which was added to silicone rubber composites to enhance the nuclear radiation shielding performances. X‐ray diffraction (XRD) characterization result showed the structure and morphology of the obtained GO‐CI nanocomposites. The mixture of GO/CI and the hybrid GO‐CI were individually incorporated into the vinyl‐terminated polydimethylsiloxane (Vi‐PDMS) to prepare referenced SR/GO/CI and SR/GO‐CI composites. Compared with SR/GO/CI, the SR/GO‐CI exhibited better thermal conduction and mechanical recovery properties. Moreover, the γ‐ray radiation shielding ability of SR/GO‐CI is much higher than that of pristine SR/GO/CI. CI particles are coated by GO nanosheets to increase surface area to prevent sedimentation of CI. It implies that SR‐GO/CI composite would have potential application as the radiation hardening material with thermal conductive and nuclear radiation shielding function.
Design, synthesis, and structure–activity studies of new rhodanine derivatives as carbonic anhydrase II, IX inhibitors
Authors: Chinchilli Krishna Kartheek , Akunuri Ravikumar , Ghouse Shaik Mahammad , Soujanya Devandla , Angeli Andrea , Parupalli Ramulu , Arifuddin Mohammed , Yaddanapudi Venkata Madhavi , Supuran Claudiu T. , Nanduri Srinivas 
Published: July 2023

AbstractRhodanine and its derivatives are an important class of heterocycles with diverse biological properties, including anticancer, antibacterial, and anti‐mycobacterial activities. In the present work, four series of new Rhodanine derivatives were synthesized and evaluated for their inhibitory activity against carbonic anhydrase I, II, IX, and XII isoforms. Interestingly, the tested compounds exhibited good inhibitory activity against the cytosolic isoform human carbonic anhydrase (hCA) II and tumor‐associated hCA IX. While the Rhodanine‐benzylidene derivatives (3a–l) and Rhodanine‐hydrazine derivatives (6a–e) are found to be selective against hCA II, the Rhodanine‐N‐carboxylate derivatives (8a–d) are found to be highly selective toward hCA IX. The Rhodanine‐linked isoxazole and 1,2,4‐oxadiazole derivatives (8ba, 8da, and 8db) exhibited inhibitory activity against hCA II and hCA IX. Among the tested compounds, 3b, 3j, 6d, and 8db were found to inhibit hCA II with Ki values of 9.8, 46.4, 7.7, and 4.7 µM, respectively. Furthermore, their mechanism of action is supported by molecular docking studies. Notably, the synthesized Rhodanine derivatives belong to a nonsulfonamide class of carbonic anhydrase inhibitors.
Effect of acclimatization rate on biogas production from anaerobic digestion of biodiesel waste products
Authors: Rackliffe Jennifer A. , Ni Ji‐Qin , Mosier Nathan S. 
Published: July 2023

AbstractDigester acclimatization can improve the efficiency of anaerobic digestion (AD), a potentially sustainable process for generating biogas from the biological decomposition of organic byproducts from biodiesel production. This study examined the impact of acclimatization rate on biogas production and conversion efficiency in laboratory digesters using inocula from a wastewater treatment plant digester and from an agro‐industrial waste digester. The results showed that co‐digestion of crude glycerol and biodiesel wastewater at high organic loading rates, up to 6.8 g chemical oxygen demand (COD) L−1 day−1, is possible without the addition of other substrates or pretreatment. Higher organic loading rates were achieved in the digesters using inocula from the agro‐industrial waste digester than in the digesters using the wastewater treatment plant digester, indicating that an inoculum with similar physical characteristics may be most appropriate for the AD of biodiesel waste. Of the two acclimatization rates studied, the slower rate improved the cumulative biogas production for both inocula. Both inocula also exhibited higher maximum daily efficiencies with a slower rate of acclimatization, up to a maximum average daily biogas yield of 621 mL biogas g−1 COD added. This implied that the rate of acclimatization can impact the ability of the digester to adapt efficiently to a new substrate.
Quality by design tool–evaluated stability‐indicating ultra‐performance liquid chromatography method for the determination of drugs (ritonavir and darunavir) used to treat the human immunodeficiency virus/acquired immunodeficiency syndrome
Authors: Menda Jyothsna , Kanuparthy Phani Raja , Katari Naresh Kumar , Kowtharapu Leela Prasad , Ettaboina Santhosh Kumar , Pydimarry Surya Prakash Rao 
Published: July 2023

AbstractRitonavir and darunavir were examined using a ultra‐performance liquid chromatography (UPLC) approach in pharmaceutical dosage forms. The small number of analytical studies that are currently available do not demonstrate the method's stability or nature. The study sought to assess both chemicals using a stability‐indicating approach with a relatively short run time. The HSS C18 (100 × 2.1 mm), 2‐mm column was used for the chromatographic separation, and isocratic elution was used to achieve this. In the mobile phase, methanol and 0.01 M phosphate buffer (pH 4.0) were included in a 60:40 (v/v) ratio. Throughout the analysis, the flow rate was kept at 0.2 mL min−1, and a photodiode array detector set to 266 nm was used to find the major components. The proposed method showed a linear response (r2 > 0.999), and the accuracy was between 98.0% and 102.0%. The precision data showed relative standard deviation ≤1.0%. The UPLC method for quantification of ritonavir and darunavir in pharmaceutical dosage forms using a very short run time of under a minute is the subject of the proposed article. To meet current regulatory criteria, the quality by design idea was used in the method performance verification.
Efficacy and safety analysis of chemotherapy combined with immunotherapy compared with standard chemotherapy for advanced biliary tract malignant tumors
Authors: Zhang Zhengfeng , Wang Dazhen , Yang Liu , Zhao Lu , Yang Lei , Zhang Jianji , Lou Changjie 
Published: July 2023

AbstractObjectiveThe treatment of biliary tract (BTC) cancer remains relatively limited, especially in the setting of advanced BTC. Immune checkpoint inhibitors (ICIs) have shown some effects in a variety of solid tumors, but their efficacy and safety in patients with advanced BTC are still elusive, which require in‐depth analysis.MethodsThe clinical information of 129 patients diagnosed with advanced BTC between 2018 and 2021 were retrospectively reviewed. All patients were treated with chemotherapy, while a portion of them (64 patients) were treated with ICIs, the other 64 patients were not. Therefore, we divided the patients into two groups, SC (standard chemotherapy) and CI (chemotherapy in combined with immunotherapy), then we analyzed the benefit of adding ICIs according to efficacy, adverse events, progression‐free survival (PFS), progressive disease (PD), and the influence of various factors and effectiveness.ResultsThe mean PFS was 9.67 months for CI group and 6.83 months for SC group. The PFS was prolonged by 2.84 months with ICI addition, and the difference was statistically significant (t = 3.114, 95% CI: 1.06–4.74, p < 0.001). The objective response rate (ORR) was 32.81% (21/64) for the CI group versus 10.77% (7/65) for the SC group, and the disease control rate (DCR) was 79.69% (51/64) versus 67.69% (44/65), respectively. Regression analysis showed that factors such as changes in CA19‐9, the level of PD‐L1 expression, tobacco and alcohol, and the neutrophil–lymphocyte (NLR) ratio all influenced PFS (p < 0.05 for all these factors). For the treatment‐related adverse events (TRAEs), the highest grade 3–4 adverse effects were thrombocytopenia in 7.75% (10/129) and neutropenia in 3.1% (4/129), immune‐related adverse events (irAEs) occurred in 32.8% (21/64), and all were grade 1–2.ConclusionsOur results showed that ICIs combined with chemotherapy exhibited good antitumor activity with acceptable safety and could be recommended as first‐line treatment for patients with advanced BTC.
Esophageal cancer patients’ need for information and support in making a treatment decision between standard surgery and active surveillance
Authors: Hermus Merel , van der Wilk Berend J. , Chang Rebecca , Dekker Jan Willem T. , Coene Peter‐Paul L. O. , Nieuwenhuijzen Grard A. P. , Rosman Camiel , Heisterkamp Joos , Hartgrink Henk H. , Timmermans Liesbeth , Wijnhoven Bas P. L. , van der Zijden Charlène J. , van Lanschot Jan J. B. , Busschbach Jan , Lagarde Sjoerd M. , Kranenburg Leonieke W. 
Published: July 2023

AbstractBackgroundThis study explores patients’ need for information and support in deciding on esophageal cancer treatment, when experimental active surveillance and standard surgery are both feasible.MethodsThis psychological companion study was conducted alongside the Dutch SANO‐trial (Surgery As Needed for Oesophageal cancer). In‐depth interviews and questionnaires were used to collect data from patients who declined participation in the trial because they had a strong preference for either active surveillance (n = 20) or standard surgery (n = 20). Data were analyzed using both qualitative and quantitative techniques.ResultsPatients prefer to receive information directly from their doctors and predominantly rely on this information to make a treatment decision. Other information resources are largely used to confirm their treatment decision. Patients highly value support from their loved ones and appreciate emphatic doctors to actively involve them in the decision‐making process. Overall, patients’ needs for information and support during decision‐making were met.ConclusionsThe importance of shared decision‐making and the role doctors have in this process is underlined. The role of doctors is essential at the initial phase of decision‐making: Once patients seem to have formed their treatment preference for either active surveillance or surgery, the influence of external resources (including doctors) may be limited.
Updated COVID‐19 clearance time among patients with cancer in the Delta and Omicron waves
Authors: Avigan Zachary M. , Paredes Rodrigo , Boussi Leora S. , Lam Barbara D. , Shea Meghan E. , Weinstock Matthew J. , Peters Mary Linton B. 
Published: July 2023

AbstractBackgroundCOVID‐19 infection delays therapy and in‐person evaluation for oncology patients, but clinic clearance criteria are not clearly defined.MethodsWe conducted a retrospective review of oncology patients with COVID‐19 at a tertiary care center during the Delta and Omicron waves and compared clearance strategies.ResultsMedian clearance by two consecutive negative tests was 32.0 days (Interquartile Range [IQR] 22.0–42.5, n = 153) and was prolonged in hematologic malignancy versus solid tumors (35.0 days for hematologic malignancy, 27.5 days for solid tumors, p = 0.01) and in patients receiving B‐cell depletion versus other therapies. Median clearance by single negative test was reduced to 23.0 days (IQR 16.0–33.0), with recurrent positive rate 25.4% in hematologic malignancy versus 10.6% in solid tumors (p = 0.02). Clearance by a predefined waiting period required 41 days until an 80% negative rate.ConclusionsCOVID‐19 clearance remains prolonged in oncology patients. Single‐negative test clearance can balance delays in care with risk of infection in patients with solid tumors.
Ameliorative Effect of Malvidin on Spleen Injury in LPS‐Induced Sepsis
Authors: Shi Jinfeng , Wang Yan , Zhang Xiao , Fan Hui , Wang Hanyu , Li Xueqing , Xu Baoshi , Qiang Jingchao , Pan Enzhuang , Chu Mingyi , Dong Jingquan , Dong Zibo 
Published: July 2023

AbstractSepsis, one of the most destructive diseases in the world, is a syndrome of systemic inflammatory response caused by the invasion of pathogenic microorganisms such as bacteria into the body. Malvidin is one of the most widespread anthocyanins, and its significant antioxidant and anti‐inflammatory activities have been widely reported. However, the effect of Malvidin on sepsis and related complications is still unclear. The present study aimed to determine the mechanisms of Malvidin's potential protection from lipopolysaccharide (LPS)‐induced spleen injury model of sepsis. In the LPS‐induced mouse spleen injury model of sepsis, pretreatment with Malvidin was performed to assess morphological damage in spleen tissue and to detect the expression of mRNA levels of serum necrosis factor α, interleukin 1β and interleukin 6, and IL‐10. Apoptosis was detected using the TUNEL technique, and the levels of oxidative stress‐related oxidase and antioxidant enzymes were measured by kit to assess the effect of Malvidin on inflammation and oxidative stress associated with septic spleen injury. The results of this study indicated that Malvidin was be a potentially effective drug for the treatment of sepsis.
Metabolomics Profiling of Tunisian Sonchus oleraceus L. Extracts and Their Antioxidant Activities
Authors: Nouidha Sameh , Selmi Salima , Guigonis Jean‐Marie , Pourcher Thierry , Chekir‐Ghedira Leila , Kilani‐Jaziri Soumaya 
Published: July 2023

AbstractSonchus oleraceus (L.) L. (Asteraceae) is an edible wild plant, known for its uses in traditional medicine. The aim of this study is to explore the phytochemical composition of the aerial parts (AP) and roots (R) of aqueous extracts of Sonchus oleraceus L. growing in Tunisia, using liquid chromatography‐tandem mass spectrometry(LC/MS/MS), and determine the content of polyphenols and antioxidant activities. Results showed that aqueous extracts of AP and R contained, respectively, 195.25±33 μg/g and 118.66±14 μg/g gallic acid equivalent (GAE), and 52.58±7 μg/g and 3.2±0.3μg/g quercetin equivalent. AP and R extracts also contained tannins, 581.78±33 μg/g and 948.44±19 μg/g GAE. The AP extract in the 1,1‐diphenyl‐2‐picrylhydrazyl (DPPH), 2,2′‐azinobis(3‐ethylbenzothiazoline‐6‐sulfonic acid) (ABTS) scavenging activities, hydroxyl radical scavenging (OH−) and in cupric reducing antioxidant activity (CUPRAC) assays were respectively 0.325±0.036 mg/mL, 0.053±0.018 mg/mL, 0.696±0.031 mg/mL and 60.94±0.004 μMTE/g, while the R extract using the same assays showed, 0.209±0.052 mg/mL, 0.034±0.002 mg/mL, 0.444±0.014 mg/mL and 50.63±0.006 μM Trolox equivalent/g, respectively. A total of 68 compounds were tentatively identified by LC/MS/MS in both extracts in which quinic acid, pyrogallol, osthrutin, piperine, gentisic acid, fisetin, luteolin, caffeic acid, gingerol, were the most abundant in the LC/MS/MS spectrum. Many of these metabolites were found for the first time in Tunisian Sonchus oleraceus L. which may take account for the antioxidant activities exhibited by the plant.
Application of a Synthetic Ferredoxin‐Inspired [4Fe4S]‐Peptide Maquette as the Redox Partner for an [FeFe]‐Hydrogenase
Authors: Bombana Andrea , Shanmugam Muralidharan , Collison David , Kibler Alexander J. , Newton Graham N. , Jäger Christof M. , Croft Anna K. , Morra Simone , Mitchell Nicholas J. 
Published: July 2023

Abstract‘Bacterial‐type’ ferredoxins host a cubane [4Fe4S]2+/+ cluster that enables these proteins to mediate electron transfer and facilitate a broad range of biological processes. Peptide maquettes based on the conserved cluster‐forming motif have previously been reported and used to model the ferredoxins. Herein we explore the integration of a [4Fe4S]‐peptide maquette into a H2‐powered electron transport chain. While routinely formed under anaerobic conditions, we illustrate by electron paramagnetic resonance (EPR) analysis that these maquettes can be reconstituted under aerobic conditions by using photoactivated NADH to reduce the cluster at 240 K. Attempts to tune the redox properties of the iron‐sulfur cluster by introducing an Fe‐coordinating selenocysteine residue were also explored. To demonstrate the integration of these artificial metalloproteins into a semi‐synthetic electron transport chain, we utilize a ferredoxin‐inspired [4Fe4S]‐peptide maquette as the redox partner in the hydrogenase‐mediated oxidation of H2.
Simultaneous diagnosis of papillary thyroid cancer and systemic mastocytosis
Authors: Brown Kevin F. , Bloomer Zachary W. , Shakir Mohamed K. M. , Cognetti Matthew J. , Muir Jeannie M. , Hoang Thanh D. 
Published: July 2023

Key Clinical MessageWhen managing patients with differentiated thyroid cancers (DTC) and lytic bone lesions, physicians should consider etiologies other than DTC bony metastases when there is no biochemical and functional radiographic evidence of extensive DTC burden.AbstractSystemic mastocytosis (SM) is a clonal expansion of mast cells associated with an increased risk of solid malignancies. There is no known association between systemic mastocytosis and thyroid cancer. We report a young woman who presented with cervical lymphadenopathy, palpable thyroid nodule, and lytic bone lesions who was diagnosed with papillary thyroid cancer (PTC). The patient's post‐surgical thyroglobulin was lower than expected for metastatic thyroid cancer, and the lytic bone lesions did not demonstrate uptake of I123. Upon further evaluation, the patient was found to have SM. We report a case of co‐occurrence of PTC and SM.
Extracorporeal membrane oxygenation as acute rescue therapy for negative pressure pulmonary edema in the post anesthesia care unit: A case report
Authors: Augustin Katrina J. , Creel‐Bulos Christina M. , Budhrani Gaurav F. , Miller Casey F. , Fiza Babar 
Published: July 2023

AbstractNegative pressure pulmonary edema (NPPE) may result in respiratory failure refractory to conventional management strategies. Venovenous extracorporeal membrane oxygenation (VV ECMO) can serve as a rescue therapy in cases of severe respiratory failure. Rapid initiation of VV ECMO can decrease morbidity and mortality while facilitating early liberation from mechanical ventilation and promoting early rehabilitation. We describe the successful utilization of VV ECMO as rescue therapy for severe NPPE‐induced hypoxic respiratory failure and peri‐arrest state in the postanesthesia care unit (PACU) in a patient with postextubation airway obstruction after undergoing patellar tendon repair.