bluuebunny/crossref_metadata_2025_split huggingface dataset:
Contribuciones del pensamiento crítico y creativo a la formación técnica industrial en bachillerato técnico
Authors: Atiencie Rodríguez Rubén Daniel , Carrillo Salvador Ronald Gilberto 
Published: July 2023

El presente trabajo investigativo tiene finalidad de analizar las contribuciones del pensamiento crítico y creativo a la formación de estudiantes del bachillerato técnico industrial mediante una investigación bibliográfica y de campo que permite tener información relevante que ayude a sustentar el tema de investigación, mediante el cual se determina que el desarrollo del pensamiento crítico y creativo es parte importante del desarrollo del ser humano que le permite mejorar las capacidades de análisis, síntesis y sea capaz de tomar decisiones de manera coherente, buscando nuevas y novedosas alternativa para la solución de problemas de su entorno. En conclusión, se puede manifestar que a más de las competencias técnicas que adquiere el estudiante, requiere de habilidades críticas y creativas para que pueda enfrentarse a los retos que le depara el futuro y para conseguirlo es necesario que el estudiante esté motivado dentro de un espacio acogedor que le permita su participación activa en clases y sin temor a equivocarse, que pueda buscar con sus compañeros de clase alternativas de solución de problemas de la vida cotidiana. Así mismo, el docente es quien debe preparar actividades que despierten en el estudiante el interés por aprender y utilizando los recursos que disponga a su alrededor pueda dar solución a los problemas de manera crítica y creativa.
8 - Actors and Institutions in Urban Politics in Nigeria: Agege (Lagos) Since the 1950s
Authors: Ayodeji Olukoju  
Published: July 2023

Unlike Lagos Island and Mushin, for example, Agege, a multi-ethnic and densely populated ward of metropolitan Lagos (originally an autonomous settlement, has suffered relative neglect in the extensive literature on Lagos. This article analyses the dynamics of power relations among the various interest groups, personalities and institutions in this ‘ward’ of Lagos since the 1950s. Combining chronological and thematic approaches, it outlines the evolution of the commu- nity and its local government system since the nineteenth century, examines the interactions of traditional and modern institutions (chieftaincy and modern po- litical offices at the local government level), the dynamics of inter-tier (state– local government) relations, the composition and activities of interest groups (specifically, religious, occupational, ethnic, youth and residential associations), and the management of common facilities (markets) and problems (communal conflict and insecurity). The study co pares Agege with a similar ward, Ajegunle, which this author has also studied.
Autoanticuerpos en miopatías inflamatorias idiopáticas: Enfoque en la práctica clínica
Authors: VALENZUELA GONZÁLEZ ROSA MARÍA 
Published: July 2023

Las miopatías inflamatorias idiopáticas (MII) conforman un grupo diverso de en­fermedades caracterizadas por lesiones musculares inmunomediadas, que pue­den estar acompañadas de manifestaciones extramusculares.
La identificación de autoanticuerpos específicos de miositis (AEM) y asociados a miositis (AAM) se ha convertido en una herramienta relevante en el diagnóstico, clasificación y pronóstico en este grupo de enfermedades.
Adquieren relevancia en el diagnóstico y determinación de pronóstico de la Enfer­medad Pulmonar Intersticial (EPI), en el diagnóstico diferencial entre subgrupos de MII, especialmente en entidades de comportamiento atípico como la Miopatía Necrotizante Inmuno Mediada (MNIM) y la Miositis por Cuerpos de Inclusión, y permiten el enfoque y seguimiento estricto en pacientes con autoanticuerpos asociados a cáncer.
En el último tiempo se ha planteado su utilidad tanto en la determinación de actividad de la enfermedad como en predecir la respuesta al tratamiento inmu- nosupresor.
Kepemimpinan Kepala PAUD dalam Pembinaan Profesional Guru
Authors: Putra Yudithia Dian 
Published: July 2023

The leadership style principles of the Saleh Children's Kindergarten in Malang, shows the ability of a leader to be able to influence and motivate teachers to be professional in their professional responsibilities as teachers. Teachers who understand that they must continue to hone, update and improve their competencies in line with advances in technology and information in the world of education. In this study, the background of a leader who is able to accommodate all the needs of teachers in a teacher professional development program with coaching techniques, a strategy implemented by exploring the potential of teachers to be able to solve all problems that arise in the learning process. The competence of leaders in an institution greatly determines the performance of teachers as human resources who have a role to design, implement and evaluate to achieve the expected learning objectives.
Keywords: leadership, professional, teacher
Oleanolic acid and moderate drinking increase the pancreatic GLP-1R expression of the β-cell mass deficiency induced hyperglycemia
Authors: Xu Li , Hu Ruibin , Jois Shreyas Venkataraman , Zhang Lei 
Published: July 2023

Background
Oleanolic acid (OA) and moderate drinking have been reported to attenuate diabetes. However, the underlying mechanism of OA and moderate drinking alone or in combination on the islet β-cell deficiency induced diabetes is not fully elucidated.

Methods
Male Sprague Dawley (SD) rats were intraperitoneally injected with 55 mg/kg streptozotocin (STZ) to induce β-cell deficiency. OA, 5% ethanol (EtOH), or a mixture of OA in 5% ethanol (OA+EtOH) were applied to three treatment groups of hyperglycemia rats for 6 weeks.

Results
STZ caused the increase of fast blood glucose (FBG) level.OA and EtOH treatment alone or in combination decreased the STZ increased FBG level during the 6 weeks of treatment. In addition, OA treatment also significantly increased the β-cell to total islet cell ratio. Both EtOH and OA+EtOH treatments promoted the increase of total islet cell number and α-cell to β-cell ratio when compared to OA group. STZ induced hyperglycemia dramatically reduced the glucagon-like peptide-1 receptor (GLP-1R) positive cells in islets, all the three treatments significantly increased the pancreatic GLP-1R positive cell number. In the meantime, STZ induced hyperglycemia suppressed the insulin mRNA expression and boosted the glucagon mRNA expression. EtOH and OA+EtOH treatments increased the insulin mRNA expression, but none of the 3 treatments altered the elevated glucagon level.

Conclusion
GLP-1R positive cell ratio in islets is crucial for the blood glucose level of diabetes. OA and 5% ethanol alone or in combination suppresses the blood glucose level of β-cell deficiency induced diabetes by increasing islet GLP-1R expression.
Prevalence of Chronic Kidney Disease in ART-Naïve Patients in Southern Nigeria: Need for Creatinine Assay
Authors: Ekanem Anyiekere M. , Motilewa Olugbemi O. , Ibara Mfon , Bassey Emem , Onukak Asukwo , Ekrikpo Udeme E. 
Published: July 2023

Aims: The current HIV treatment strategy of 'test and start' requires clients diagnosed with HIV to be commenced on antiretroviral therapy (ART) the same day or within one week of HIV diagnosis. However, chronic kidney disease (CKD) is a complication of Human Immunodeficiency Virus (HIV) disease and an adverse event associated with using some antiretroviral drugs (ARDs). The aim of this study was to determine the proportion of ART-naïve patients with serum creatinine assay to assess their kidney functions before the commencement of ART and the prevalence of CKD among them.
Study Design: This was a cross-sectional study.
Place and Duration of Study: The study was conducted in an HIV comprehensive treatment centre of a tertiary health facility in southern Nigeria from July to December 2019.
Methodology: The medical records of 159 ART-naïve adult patients newly enrolled into HIV care over a six months period were reviewed. Sociodemographic and clinical data were abstracted. CKD was defined as an estimated glomerular filtration rate (eGFR) of <60ml/min/1.732m2.
Results: All the newly enrolled patients were commenced on first-line ARDs. More than half (92,57.9%), were females. The mean age of respondents was 37.3± 10.1 years. Only ninety-one (57.2%) had creatinine assay documented pre-ART commencement, with a similar proportion in males and females (p=0.24). The prevalence of CKD was 15.5% (95% CI: 8.7 - 24.5%)
Conclusion: About two out of every five patients had no documented creatinine assay pre-ART commencement.The prevalence of CKD among ART-naïve patients with creatinine assay before the commencement of ARDs was moderate. A policy change that supports free or subsidized serum creatinine test using point-of-care creatinine machines in all HIV treatment centres to assess kidney function of HIV patients before ART initiation is recommended.
Validation of a Proprietary Deterioration Index Model and Performance in Hospitalized Adults
Authors: Byrd Thomas F. , Southwell Bronwyn , Ravishankar Adarsh , Tran Travis , Kc Abhinab , Phelan Tom , Melton-Meaux Genevieve B. , Usher Michael G. , Scheppmann Daren , Switzer Sean , Simon Gyorgy , Tignanelli Christopher J. 
Published: July 2023

ImportanceThe Deterioration Index (DTI), used by hospitals for predicting patient deterioration, has not been extensively validated externally, raising concerns about performance and equitable predictions.ObjectiveTo locally validate DTI performance and assess its potential for bias in predicting patient clinical deterioration.Design, Setting, and ParticipantsThis retrospective prognostic study included 13 737 patients admitted to 8 heterogenous Midwestern US hospitals varying in size and type, including academic, community, urban, and rural hospitals. Patients were 18 years or older and admitted between January 1 and May 31, 2021.ExposureDTI predictions made every 15 minutes.Main Outcomes and MeasuresDeterioration, defined as the occurrence of any of the following while hospitalized: mechanical ventilation, intensive care unit transfer, or death. Performance of the DTI was evaluated using area under the receiver operating characteristic curve (AUROC) and area under the precision recall curve (AUPRC). Bias measures were calculated across demographic subgroups.ResultsA total of 5 143 513 DTI predictions were made for 13 737 patients across 14 834 hospitalizations. Among 13 918 encounters, the mean (SD) age of patients was 60.3 (19.2) years; 7636 (54.9%) were female, 11 345 (81.5%) were White, and 12 392 (89.0%) were of other ethnicity than Hispanic or Latino. The prevalence of deterioration was 10.3% (n = 1436). The DTI produced AUROCs of 0.759 (95% CI, 0.756-0.762) at the observation level and 0.685 (95% CI, 0.671-0.700) at the encounter level. Corresponding AUPRCs were 0.039 (95% CI, 0.037-0.040) at the observation level and 0.248 (95% CI, 0.227-0.273) at the encounter level. Bias measures varied across demographic subgroups and were 14.0% worse for patients identifying as American Indian or Alaska Native and 19.0% worse for those who chose not to disclose their ethnicity.Conclusions and RelevanceIn this prognostic study, the DTI had modest ability to predict patient deterioration, with varying degrees of performance at the observation and encounter levels and across different demographic groups. Disparate performance across subgroups suggests the need for more transparency in model training data and reinforces the need to locally validate externally developed prediction models.
Synchronous Diagnosis of Respiratory Viruses Variants via Receptonics Based on Modeling Receptor‒Ligand Dynamics
Authors: Seo Sung Eun , Kim Kyung Ho , Ha Siyoung , Oh Hanseul , Kim Jinyeong , Kim Soomin , Kim Lina , Seo Minah , An Jai Eun , Park Yoo Min , Lee Kyoung G. , Kim Yu Kyung , Kim Woo‐Keun , Hong Jung Joo , Song Hyun Seok , Kwon Oh Seok 
Published: July 2023

AbstractThe transmission and pathogenesis of highly contagious fatal respiratory viruses are increasing, and the need for an on‐site diagnostic platform has arisen as an issue worldwide. Furthermore, as the spread of respiratory viruses continues, different variants have become the dominant circulating strains. To prevent virus transmission, the development of highly sensitive and accurate on‐site diagnostic assays is urgently needed. Herein, a facile diagnostic device is presented for multi‐detection based on the results of detailed receptor‒ligand dynamics simulations for the screening of various viral strains. The novel bioreceptor‐treated electronics (receptonics) device consists of a multichannel graphene transistor and cell‐entry receptors conjugated to N‐heterocyclic carbene (NHC). An ultrasensitive multi‐detection performance is achieved without the need for sample pretreatment, which will enable rapid diagnosis and prevent the spread of pathogens. This platform can be applied for the diagnosis of variants of concern in clinical respiratory virus samples and primate models. This multi‐screening platform can be used to enhance surveillance and discriminate emerging virus variants before they become a severe threat to public health.
Realizing Photocatalytic Overall Water Splitting by Modulating the Thickness‐Induced Reaction Energy Barrier of Fluorenone‐Based Covalent Organic Frameworks
Authors: Shen Rongchen , Qin Chaochao , Hao Lei , Li Xiuzhi , Zhang Peng , Li Xin 
Published: July 2023

AbstractDirect photocatalytic hydrogen and oxygen evolution from water splitting is an attractive approach for producing chemical fuels. In this work, a novel fluorenone‐based covalent organic framework (COF‐SCAU‐2) is successfully exfoliated into ultrathin three‐layer nanosheets (UCOF‐SCAU‐2) for photocatalytic overall water splitting (OWS) under visible light. The ultrathin structures of UCOF‐SCAU‐2 greatly enhance carrier separation, utilization efficiency, and the exposure of active surface sites. Surprisingly, UCOF‐SCAU‐2 exhibits efficient photocatalytic OWS performance, with hydrogen and oxygen evolution rates reaching 0.046 and 0.021 mmol h−1 g−1, respectively, under visible‐light irradiation, whereas bulk COF‐SCAU‐2 shows no activity for photocatalytic OWS. Charge‐carrier kinetic analysis and DFT calculations confirm that reducing the thickness of the COF nanosheets increases the number of accessible active sites, reduces the distance for charge migration, prolongs the lifetimes of photogenerated carriers, and decreases the Gibbs free energy of the rate‐limiting step compared to nonexfoliated COFs. This work offers new insights into the effect of the layer thickness of COFs on photocatalytic OWS.
High‐Performance Semitransparent Color Organic Photodiodes Enabled by Integrating Fabry–Perot and Solution‐Processed Distributed Bragg Reflectors
Authors: Kim Bo Youn , Shafian Shafidah , Kim Kyungkon 
Published: July 2023

AbstractOrganic photodiodes (OPDs) have recently garnered attention as a competitive alternative to their inorganic counterparts, given their inherent advantages in solution processability, mechanical flexibility, and cost‐effective manufacturing. In this work, a novel method for fabricating high‐performance semitransparent color OPDs by integrating Fabry–Perot (FP) interferometer‐based color‐filtering electrodes and solution‐processed distributed Bragg reflectors (sDBRs) is introduced. The FP electrode provides color control by modulating the metal oxide layer thickness, irrespective of the photoactive layer's color. To overcome limitations related to light absorption and device transparency, this work employs a sDBR as a selective window reflector, allowing the OPD to retain its color while preserving semitransparency. The experimental findings demonstrate the successful integration of these components, resulting in semitransparent red, green, and blue (RGB) OPDs exhibiting significantly improved detectivity. The fabricated RGB‐OPDs achieve detectivity values of 4.07, 3.49, and 4.22 × 1010 cm Hz1/2 W−1 for red, green, and blue, respectively. This research highlights the efficacy of FP and sDBR color filters in realizing high‐performance color sensors and offer novel opportunities for semitransparent OPD integration with other optoelectronic devices.
Protein‐Based Face Mask with High SARS‐CoV‐2 Neutralization Ability and Breathability
Authors: Zhang Bao‐Zhong , Au‐Yeung Yee‐Man , Yuen Terrence Tsz‐Tai , Xu Xiaoyun , Gong Hua‐Rui , Zeng Zheng , Li Renhao , Hu Jinlian , Chu Hin , Huang Jian‐Dong 
Published: July 2023

AbstractCurrent intramuscular vaccines cannot effectively prevent severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) transmission and infection in nasal epithelium. Although face masks represent an additional preventive measure against SARS‐CoV‐2, their low breathability hinders wearing compliance. Herein, the development of SuperNeut, a protein‐based breathable high‐efficiency face mask, is reported. The mask contains KP‐LCB1, a fusion protein that can capture SARS‐CoV‐2 spike proteins on one end and attach to keratin fibres on the other. The meltblown fabric is replaced by a thin electrospun keratin layer that allows uniform adhesion of KP‐LCB1, which serves as an effective barrier to filter incoming viruses, while substantially improving breathability. The studies demonstrate that the fusion protein is stable and can efficiently neutralise multiple SARS‐CoV‐2 wildtype (WT), Alpha (B.1.1.7), Delta (B.1.617.2), and Omicron (B.1.1.529). The breathability of SuperNeut mask compared to commercial surgical masks is also quantified. Importantly, it is shown that SuperNeut Mask is able to effectively prevent SARS‐CoV‐2 Delta transmission in Syrian hamster model. Overall, the highly breathable SuperNeut mask can efficiently prevent SARS‐CoV‐2 transmission. This design serves as a proof‐of‐concept that face mask designs can be improved with biological components. The neutralising proteins in this mask can be altered to combat future respiratory disease outbreaks.
Biocompatible Solid‐State Ion‐Sensitive Organic Electrochemical Transistor for Physiological Multi‐Ions Sensing
Authors: Moudgil Akshay , Hou Kunqi , Li Ting , Leong Wei Lin 
Published: July 2023

AbstractWearable bioelectronic sensors have gained tremendous prominence and applicability in healthcare technologies as they offer an alternative to traditional clinical testing and health monitoring. However, many challenges must be overcome for off‐site and point‐of‐care commercial applications, including sensitivity, selectivity, multiple analyte detection, sample procurement technique, invasiveness, biocompatibility, and accurate real‐time sensing. Specifically, a wearable sweat‐based diagnostic biosensing platform offers a noninvasive way for rapid and real‐time monitoring of various physiological biomarkers. This work develops a flexible solid‐state organic electrochemical transistor with an extended sensing node for multi‐ions sensing in the physiological range with high selectivity, fast response, and superior sensitivity. The solid‐contact architecture is implemented for easy sample handling, processability, device miniaturization, and flexibility. For the first time, multiplexed ions (sodium (Na+), potassium (K+), and calcium (Ca2+)) sensing with the integration of ion‐selective membranes and biocompatible semiconducting channel in an extended gate‐solid‐state organic electrochemical transistor (ExG‐SSOECT) is presented. The integrated ExG‐SSOECT device platform exhibits improved performance among the available wearable sensors and offers great potential to be a suitable biochemical sensor in wearable bioelectronics.
TiO2 Passivated Zno Nanoarray Layer Based Fluoroalkylsilane Film for Photovoltaic Optical Glass: Achieving UV Shielding, Acid Rain Resistance, and Self‐Cleaning Properties
Authors: Ma Xin , Yin Yutong , Song Jiali , Nong Zequan , Chandrasekaran Sundaram , Liu Chenglu , Cheng Shengye , Hu Zhichang , Wu Lina , Han Faming , Liu Yongping , Chen Yiwang 
Published: July 2023

AbstractPhotovoltaic technology is a prominent source of renewable energy, but maintenance costs and efficiency attenuation of large photovoltaic devices are significant issues due to their vast energy conversion area. To reduce costs and facilitate maintenance, superhydrophobic surfaces with self‐cleaning properties have been developed for photovoltaic glass. In this study, transparent ZnO nanoarrays (NAs) are synthesized on photovoltaic glass, with Eu3+ doping enhancing the ultraviolet radiation resistance of photovoltaic devices and slightly increasing visible transmittance. A TiO2 passivation layer is introduced on the ZnO NAs surface to enhance acid resistance and mitigate corrosion caused by acidic rainwater. Fluoroalkylsilane (POTS) modification achieves superhydrophobicity with a water contact angle of 160.25°, as demonstrated by droplet rolling experiments. Micro‐interaction of superhydrophobic properties is further investigated by force curve measurement using atomic force microscope, showing almost no nanometer water moisture on the superhydrophobic surface, but conspicuous water moisture on the control glass surface. Finally, simulated models and practical silicon crystal solar cells fabricated using the self‐cleaning glass show excellent acid rain resistance, self‐cleaning, and long service life properties, with no power conversion efficiency degeneration during a 40‐day outdoor application test.
Micro‐Engineered Organoid‐on‐a‐Chip Based on Mesenchymal Stromal Cells to Predict Immunotherapy Responses of HCC Patients
Authors: Zou Zhengyu , Lin Zhun , Wu Chenglin , Tan Jizhou , Zhang Jie , Peng Yanwen , Zhang Kunsong , Li Jiaping , Wu Minhao , Zhang Yuanqing 
Published: July 2023

AbstractHepatocellular carcinoma (HCC) is one of the most lethal cancers worldwide. Patient‐derived organoid (PDO) has great potential in precision oncology, but low success rate, time‐consuming culture, and lack of tumor microenvironment (TME) limit its application. Mesenchymal stromal cells (MSC) accumulate in primary site to support tumor growth and recruit immune cells to form TME. Here, MSC and peripheral blood mononuclear cells (PBMC) coculture is used to construct HCC organoid‐on‐a‐chip mimicking original TME and provide a high‐throughput drug‐screening platform to predict outcomes of anti‐HCC immunotherapies. HCC‐PDOs and PBMC are co‐cultured with MSC and Cancer‐associated fibroblasts (CAF). MSC increases success rate of biopsy‐derived PDO culture, accelerates PDO growth, and promotes monocyte survival and differentiation into tumor‐associated macrophages. A multi‐layer microfluidic chip is designed to achieve high‐throughput co‐culture for drug screening. Compared to conventional PDOs, MSC‐PDO‐PBMC and CAF‐PDO‐PBMC models show comparable responses to chemotherapeutic or targeted anti‐tumor drugs but more precise prediction potential in assessing patients’ responses to anti‐PD‐L1 drugs. Moreover, this microfluidic platform shortens PDO growth time and improves dimensional uniformity of organoids. In conclusion, the study successfully constructs microengineered organoid‐on‐a‐chip to mimic TME for high‐throughput drug screening, providing novel platform to predict immunotherapy response of HCC patients.
Tert‐Butylnitrite Mediated Regioselective C(sp2)−3 Nitration of Substituted 4‐Quinolones and Its Late‐stage Manipulations
Authors: Ghosh Prasanjit , Chhetri Gautam , Mandal Anirban , Mahato Manas , Das Sajal 
Published: July 2023

AbstractA novel and eco‐friendly technique for the synthesis of C‐3 nitro derivatives of 4‐quinolones via the regioselective C(sp2)−H bond functionalization employing tert‐butyl nitrite as nitrating agent in presence of TEMPO [(2,2,6,6‐tetramethylpiperidin‐1‐yl)oxyl] as an oxidant is unfolded herein. The protocol is scalable as well as high yielding with wide substrate scope and broad functional group tolerance. In‐depth mechanistic investigations revealed that the reaction occurred through a free radical pathway. The nitro derivatives of 4‐quinlones were selectively reduced to corresponding aminated 4‐quinolones. Finally, the photophysical properties of synthesized amine derivatives were also investigated, and some of them showed good fluorescence properties.