bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neodymium budget in the Mediterranean Sea: evaluating the role of atmospheric dusts using a high-resolution dynamical-biogeochemical model
Authors: Ayache Mohamed , Dutay Jean-Claude , Tachikawa Kazuyo , Arsouze Thomas , Jeandel Catherine 
Published: January 2023

Abstract. The relative importance of river solid discharge, deposited sediment remobilisation, and atmospheric dust as sources of neodymium (Nd) to the ocean is the subject of ongoing debate, the magnitudes of these fluxes being associated with a significant uncertainty. The Mediterranean basin is a specific basin; it receives a vast amount of emissions from different sources and is surrounded by continental margins, with a significant input of dust as compared to the global ocean. Furthermore, it is largely impacted by the Atlantic water inflow via the Strait of Gibraltar.
Here, we present the first simulation of dissolved Nd concentration ([Nd]) and Nd isotopic composition (εNd) using a high-resolution regional model (NEMO/MED12/PISCES) with an explicit representation of all Nd inputs, and the internal cycle, i.e. the interactions between the particulate and dissolved phases. The high resolution of the oceanic model (at 1/12∘), essential to the simulation of a realistic Mediterranean circulation in present-day conditions, gives a unique opportunity to better apprehend the processes governing the Nd distribution in the marine environment. The model succeeds in simulating the main features of εNd and produces a realistic distribution of [Nd] in the Mediterranean Sea. We estimated the boundary exchange (BE, which represents the transfer of elements from the margin to the sea and their removal by scavenging) flux at 89.43 × 106 g(Nd) yr−1, representing ∼84.4 % of the total external Nd source to the Mediterranean basin. The river discharge provided 3.66 × 106 g(Nd) yr−1, or 3.5 % of the total Nd flow into the Mediterranean. The flux of Nd from partially dissolved atmospheric dusts was estimated at 5.2 × 106 g(Nd) yr−1, representing 5 % of the total Nd input, and 7.62 × 106 g(Nd) yr−1 comes from the Atlantic across the Strait of Gibraltar, i.e. 7.1 % of the total Nd input. The total quantity of Nd in the Mediterranean Sea was estimated to 7.28 × 109 g(Nd); this leads to a new calculated Nd residence time of ∼68 year. This work highlights that the impact of river discharge on [Nd] is localised near the catchments of the main rivers. In contrast, the atmospheric dust input has a basin-wide influence, correcting for a too-radiogenic εNd when only the BE input is considered and improving the agreement of simulated dissolved Nd concentration with field data. This work also suggests that εNd is sensitive to the spatial distribution of Nd in the atmospheric dust, and that the parameterisation of the vertical cycling (scavenging/remineralisation) considerably constrains the ability of the model to simulate the vertical profile of εNd.
Modeled storm surge changes in a warmer world: the Last Interglacial
Authors: Scussolini Paolo , Dullaart Job , Muis Sanne , Rovere Alessio , Bakker Pepijn , Coumou Dim , Renssen Hans , Ward Philip J. , Aerts Jeroen C. J. H. 
Published: January 2023

Abstract. The Last Interglacial (LIG; ca. 125 ka) is a period of interest for climate research as it is the most recent period of the Earth's history when the boreal climate was warmer than at present. Previous research, based on models and geological evidence, suggests that the LIG may have featured enhanced patterns of ocean storminess, but this remains hotly debated. Here, we apply state-of-the-art climate and hydrodynamic modeling
to simulate changes in sea level extremes caused by storm surges, under LIG
and pre-industrial climate forcings. Significantly higher seasonal LIG sea
level extremes emerge for coastlines along northern Australia, the
Indonesian archipelago, much of northern and eastern Africa, the Mediterranean Sea, the Gulf of Saint Lawrence, the Arabian Sea, the east
coast of North America, and islands of the Pacific Ocean and of the Caribbean. Lower seasonal LIG sea level extremes emerge for coastlines along the North Sea, the Bay of Bengal, China, Vietnam, and parts of Central America. Most of these anomalies are associated with anomalies in seasonal sea level pressure minima and in eddy kinetic energy calculated from near-surface wind fields, and therefore seem to originate from anomalies in the meridional position and intensity of the predominant wind bands. In a qualitative comparison, LIG sea level extremes seem generally higher than those projected for future warmer climates. These results help to constrain the interpretation of coastal archives of LIG sea level indicators.
Hematological alterations associated with antiretroviral therapy in patients with human immunodeficiency virus
Authors: Carla María Taimal Sárez , Reiban Espinoza Esteban Adrián , Flores Siranaula Giselle Marina , Chuquitarco Marín Paul Alexis 
Published: January 2023

Introduction: hematological alterations are very frequent and of multifactorial origin, they have been related to an increased risk of pathology progression and morbimortality in patients infected by the human immunodeficiency virus. Although there is a wide variety of scientific studies on the prevalence and pathogenesis of these alterations in HIV-positive patients, there are few investigations in our environment that report on the positive or negative effect of the administration of antiretroviral drugs.Objective: to determine the main hematologic alterations associated with antiretroviral therapy in patients infected by the human immunodeficiency virus.Method: narrative bibliographic review. The following databases were used for the research: PubMed, Cochrane and Scopus. Results: the prevalence of at least one hematological alteration was 1,1-58,6 % among HIV-infected patients receiving ART. The most frequent cytopenia was anemia followed by leukopenia and thrombocytopenia. Among the most significant risk factors, patients older than 50 years, female sex, zidovudine-based antiretroviral regimen, low BMI and CD4 T-cell count, high viral load, advanced stage and opportunistic infections were identified.Conclusions: the toxicity of antiretroviral drugs and the clinical conditions of the HIV-positive patient result in altered hematopoiesis affecting all three cell lines, patients may present with anemia, leukopenia, thrombocytopenia and/or pancytopenia. Failure to monitor and identify these disorders has a serious impact on the natural history of the disease in the patient
Bacteriological profile of diabetic foot infections and their antibiotic treatment of choice
Authors: Chuquitarco Marín Paul Alexis , Chunchi Ayala Luis Mario , Gómez Guapizaca Kelly Paola , Taimal Sárez Carla María 
Published: January 2023

Introduction: diabetes mellitus is a metabolic disease in constant increase and with alarming projections in terms of incidence; likewise, the complications associated with this pathology are very frequent, such as the development of ulcers at foot level and their infection, which represent the main reasons for hospitalization and lower limb amputations.Aim: to describe the bacteriological profile of diabetic foot infections and their antibiotic treatment of choice.Methods: the study was non-experimental systematic review type following PRISMA methodology, in databases such as Pubmed, ScienceDirect, Scopus, Lilacs and Dialnet, considering certain inclusion criteria as articles published between January 2017 - December 2022. Results: a total of 9 articles were identified that met the eligibility criteria, identifying five most frequent bacteria such as Staphylococcus spp, Pseudomonas aeruginosa, among others. On the other hand, antibiotic groups such as penicillins associated with beta-lactamase inhibitors, third generation cephalosporins, among others, are drugs with high antibiotic sensitivity for the most frequent agents of diabetic foot infections. Conclusions: based on the review performed, it is possible to conclude that diabetic foot infections are generally polymicrobial, being the Gram-negative group bacteria the most predominant compared to the Gram-positive group; additionally, for the antibiotic treatment of diabetic foot infections, it should be considered to cover the most frequent infectious agents.
متطلبات تطبيق معايير الاعتماد المدرسي في مدارس التعليم العام من وجهة نظر مديري المدارس الثانوية ومشرفي الإدارة المدرسية بمكة المكرمة
Authors: المالكي عبدالرحمن بن دخيل 
Published: January 2023

هدفت الدراسة إلى التعرف على متطلبات تطبيق معايير الاعتماد المدرسي في مدارس التعليم العام بمكة المكرمة. وتحديد مدى توافر متطلبات تطبيق معيار (القيادة التربوية الفعالة، الشراكة المجتمعية ، المباني المدرسية ،التخطيط للجودة والتحسين المستمر) في مدارس التعليم العام بمكة، وأيضاً التعرف على الفروق ذات الدلالة الاحصائية بين استجابات أفراد المجتمع تعزى للمتغيرات التالية: (المسمى الوظيفي، الخبرة، الدورات التدريبية في مجال الجودة)، واستخدمت الدراسة المنهج الوصفي المسحي. وتم بناء الاستبانة من أربعة محاور، وتكون مجتمع الدراسة من جميع مديري المدارس الثانوية ومشرفي الادارة المدرسية بمكة المكرمة. وتوصلت الدراسة إلى عدة نتائج أهمها: تتوافر متطلبات تطبيق بعض معايير الاعتماد المدرسي في مدارس التعليم العام من وجهه نظر مديري المدارس الثانوية ومشرفي الإدارة المدرسية بمكة المكرمة بدرجة متوسطة، أيضاً عدم وجود فروق ذات دلالة إحصائية عند مستوى الدلالة الإحصائية (0.05α≤) بين متوسطات استجابات مديري المدارس الثانوية ومشرفي الإدارة المدرسية تعزى لمتغيري (المسمى الوظيفي، والدورات التدريبية) على مجالات أداة الدراسة،أيضاً وجو د فروق ذات دلالة إحصائية عند مستوى الدلالة الإحصائية (0.05α≤) بين متوسطات استجابات مديري المدارس الثانوية ومشرفي الإدارة المدرسية تعزى لمتغير (الخبرة) في مجال المباني المدرسية ولصالح ذوي الخبرة الطويلة، وعدم وجود فروق ذات دلالة إحصائية لمستويات الخبرة على المجالات الكلية. وأوصت الدراسة بمنح مدير المدرسة الصلاحيات الكافية لاتخاذ القرارات المهمة داخل المدرسة بما يضمن تحقيق أهدافها. وإشراك المجتمع المحلي في حل مشاكل الطلاب داخل المدرسة.
أثر استراتيجية التساؤل الذاتي (K.W.L) في اكتساب المفاهيم العلمية في مادة العلوم للصف السابع الأساسي وتنمية دافعيتهم نحو تعلم العلوم في العاصمة عمان
Authors: ديوان سميرة محمد جبران 
Published: January 2023

هدفت الدراسة الحالية إلى الكشف عن أثر استراتيجية التساؤل الذاتي (K.W.L) في اكتساب المفاهيم العلمية والدافعية نحو تعلم مادة العلوم لدى طلبة الصف السابع الأساسي في مادة العلوم للصف السابع الأساسي في مديرية التربية والتعليم في قصبة عمان، ولتحقيق هدف الدراسة تم استخدام المنهج شبه التجريبي، وتكونت عينة الدراسة من(81) طالباً وطالبة تم اختيارهم بطريقة قصدية من طلبة الصف السابع الأساسي تم عشوائيا تحديد إحداها كمجموعة ضابطة بلغ عددها (40) طالباً وطالبة، والاخرى تجريبية بلغت (41) طالباً وطالبة درست باستراتيجية التساؤل الذاتي (L.W.L)، حيث تم بناء المادة التعليمية وفق باستراتيجية التساؤل الذاتي، وتم استخدام اختبار لاكتساب المفاهيم ومقياس الدافعية نحو تعلم العلوم، تم التحقق من خصائصهما السيكومترية. توصلت الدراسة إلى وجود فروق ذات دلالة إحصائيةً عند مستوى دلالة (α≤0.05) بين متوسطات درجات أفراد المجموعتين التجريبية والضابطة في القياس البعدي على اختبار اكتساب المفاهيم ومقياس الدافعية نحو تعلم العلوم، حيث بلغت قيمة (ت) المحسوبة =(-5.738)، مما يشير الى وجود أثر لاستراتيجية التساؤل الذاتي (K.W.L) في اكتساب المفاهيم العلمية في مادة العلوم لدى طلبة الصف السابع الأساسي وتنمية دافعيتهم نحو تعلم العلوم.
تقنية البلوكتشين وتطبيقاتها الاقتصادية
Authors: آمال مرزوق 
Published: January 2023

ملخص الدراسة:
نحن على أبواب الانتقال من الاقتصاد القائم على الصناعة إلى الاقتصاد التقني بمختلف أدواته التكنولوجية والتي تعتبر تقنية البلوك تشين المكون الأحدث فيها. وتشكل هذه التقنية حجر الأساس في العملات الرقمية المشفرة مثل البتكوين والريبل، ولكن تبين أن للبلوك تشين استعمالات أخرى ومنه يهدف هذا البحث إلى تسليط الضوء على ماهية هذه التقنية والتطبيقات الواعدة التي تتيحها في مختلف القطاعات خاصة الاقتصادية منها. وتوصل البحث إلى أن سلسلة الكتل تقنية رقمية ابتكرت لتحل مشكلة انعدام الثقة عند إجراء المعاملات بين طرفين بدون الحاجة لطرف ثالث وسيط بينهما، ومنه فهي تقنية جد فعالة لتبادل القيم عبر الانترنيت. وهناك العديد من المشاريع الحقيقية الفعلية التي تستخدم تقنية البلوك تشين مع نتائج ملموسة عدا عن العملات المشفرة، مثل الخدمات المالية وسجلات الملكية والخدمات الحكومية وغيرها. كما تشهد توجه كبير لمختلف القطاعات الاقتصادية إليها لأنها تمكن من أداء الأعمال بفعالية وشفافية وبتكلفة أقل.
المضامين المرورية في كُتب اللّغة العربيِّة للمرحلة الأساسية العليا في الأردن: دراسة تحليلية
Authors: البرديني محمد حجازي 
Published: January 2023

هَدفت هذه الدِّراسة إلى الكشف عن المضامين المروية، و درجة تضمين في كُتب اللغة العربيِّة، وتكوّنت عينة الدِّراسة من مجتمع الدِّراسة نفسه، وهي كُتب اللغة العربيِّة للمرحلة الأساسية العليا الصادرة عن وزارة التّربية والتَّعليم للعام الدّراسي 2017/2018. وتحقيقاً لأهداف الدِّراسة، طوّر الباحث أداة قياس وتحليل اشتملت على ثلاثة مجالات تضمَّنت ستة عشر مضموناً ، وقد تمّ عرض الأداة على لجنة من المحكِّمين المتخصّصين في المناهج؛ للتأكد من صدقها، ثمّ قام الباحث بعملية التحليل حيث تمّ تكليف احد المعلمين، ويحمل درجة الدكتوراة في اللغة العربيِّة للقيام بعملية التَّحليل أيضاً، وقد تمّ استخراج معامل الثّبات باستخدام معادلة هولستي ( Holesti ) للثّبات، حيث بلغ معامل الثبات عبر الزمن(2.91 %)، وعبر الأشخاص ( 6.86 %)، وهذا المعامل مقبول لأغراض الدِّراسة، وقد تمّ استخدام التّكرارات والنسب المئويِّة، والرُّتب، وكشفت نتائج الدراسة عن تدنّي توافر المضامين المرورية في تلك الكُتب . وفي ضَوء نتائج الدّراسة أوصى الباحث بتضمين المضامين المرورية في كُتب اللغة العربيِّة للمرحلة الأساسية العليا في الأردن، بإدخال معلومات مفاهيم مرورية، أو ربط المحتوى بموضوعات وقضايا متعلقة المضامين المرورية ؛ ولأهميتهما في حياة الفرد والمجتمع.
Dysregulation of the PRUNE2/PCA3 genetic axis in human prostate cancer: from experimental discovery to validation in two independent patient cohorts
Authors: Lauer Richard C , Barry Marc , Smith Tracey L , Thomas Andrew Maltez , Wu Jin , Du Ruofei , Lee Ji-Hyun , Rao Arpit , Dobroff Andrey S , Arap Marco A , Nunes Diana N , Silva Israel T , Dias-Neto Emmanuel , Chen Isan , McCance Dennis J , Cavenee Webster K , Pasqualini Renata , Arap Wadih 
Published: January 2023

Background:We have previously shown that the long non-coding (lnc)RNA prostate cancer associated 3 (PCA3; formerly prostate cancer antigen 3) functions as a trans-dominant negative oncogene by targeting the previously unrecognized prostate cancer suppressor gene PRUNE2 (a homolog of the Drosophila prune gene), thereby forming a functional unit within a unique allelic locus in human cells. Here, we investigated the PCA3/PRUNE2 regulatory axis from early (tumorigenic) to late (biochemical recurrence) genetic events during human prostate cancer progression.Methods:The reciprocal PCA3 and PRUNE2 gene expression relationship in paired prostate cancer and adjacent normal prostate was analyzed in two independent retrospective cohorts of clinically annotated cases post-radical prostatectomy: a single-institutional discovery cohort (n=107) and a multi-institutional validation cohort (n=497). We compared the tumor gene expression of PCA3 and PRUNE2 to their corresponding expression in the normal prostate. We also serially examined clinical/pathological variables including time to disease recurrence.Results:We consistently observed increased expression of PCA3 and decreased expression of PRUNE2 in prostate cancer compared with the adjacent normal prostate across all tumor grades and stages. However, there was no association between the relative gene expression levels of PCA3 or PRUNE2 and time to disease recurrence, independent of tumor grades and stages.Conclusions:We concluded that upregulation of the lncRNA PCA3 and targeted downregulation of the protein-coding PRUNE2 gene in prostate cancer could be early (rather than late) molecular events in the progression of human prostate tumorigenesis but are not associated with biochemical recurrence. Further studies of PCA3/PRUNE2 dysregulation are warranted.Funding:We received support from the Human Tissue Repository and Tissue Analysis Shared Resource from the Department of Pathology of the University of New Mexico School of Medicine and a pilot award from the University of New Mexico Comprehensive Cancer Center. RP and WA were supported by awards from the Levy-Longenbaugh Donor-Advised Fund and the Prostate Cancer Foundation. EDN reports research fellowship support from the Brazilian National Council for Scientific and Technological Development (CNPq), Brazil, and the Associação Beneficente Alzira Denise Hertzog Silva (ABADHS), Brazil. This work has been funded in part by the NCI Cancer Center Support Grants (CCSG; P30) to the University of New Mexico Comprehensive Cancer Center (CA118100) and the Rutgers Cancer Institute of New Jersey (CA072720).
Intensification Dimension of Prices Cryptocurrency with Hamiltonian Quantum Mechanics
Authors: Faris Mahrus , Fauzan Rizky , Wendy . , Komari Nurul , Purnomo Bintoro Bagus 
Published: January 2023

Aims: Cryptocurrency (CC) is a digital currency innovation that has impacted the financial sector's distribution mechanism since December 2013. This research aims to discover a non-linear mathematical Quantum relationship between the escalation of the development of cryptocurrency price fluctuations and prices in CC predictors.
Study Design: The research uses simulation techniques to operate numerical models that correspond to the process of dynamic observation behavior.
Place and Duration of Study: Types of crypto chosen based on this research data are Bitcoin (BTC), Ethereum (ETH), USD Coin (USDC), and Binance (BNB). The data collection period coverage is required with a number per week from 2019 to 2021 or 52 weeks.
Methodology: From the collection of crypto prices that have been selected, there are 157 data samples taken using a systematic sampling strategy with elements that are randomly selected and then followed by the next element from the column on the table after the first choice. The conceptual form of the research background is modeled by a multiple regression term equation which predicts a continuous variable unit as a non-linear mathematical function.
Results: The results of the research study found that the most prominent altcoins traded in the market are not affected by the price of Bitcoin securities. Percentage-wise, there were 40.33% of factors that influenced the movement of crypto coin price progress, with 59.67% being the remaining limiting factors in the study. Partial results show Bitcoin and altcoin assets have arbitrage potential with significant positives on put option volatility with asset discounting producing negative results and martingale strategies arising from a Hamiltonian perspective.
Conclusion: By time limitations, BTC and USDC have the most potential in martingale conditions, while the cryptocurrency ETH might be a solution in picking assets with growing values at medium risk. Meanwhile, crypto BNB is an asset that offers new data on many market indices.
Clinically Relevant Subgroups Among Athletes Who Have Ruptured Their Anterior Cruciate Ligaments: A Delaware‐Oslo Cohort Study
Authors: Arhos Elanna K. , Pohlig Ryan T. , Di Stasi Stephanie , Risberg May Arna , Snyder‐Mackler Lynn , Silbernagel Karin Grävare 
Published: January 2023

ObjectiveTo identify subgroups of individuals with anterior cruciate ligament (ACL) injuries based on patient characteristics, self‐reported outcomes, and functional performance at baseline, and to associate subgroups with long‐term outcomes after ACL rupture.MethodsA total of 293 participants (45.7% male, mean ± SD age 26.2 ± 9.4 years, days from injury 58 ± 35) were enrolled after effusion, pain, and range of motion impairments were resolved and quadriceps strength was at least 70% of the uninvolved limb. Mixture modeling was used to uncover latent subgroups without a prior group classification using probabilistic assignment. Variables include demographics, functional testing, and self‐reported outcome measures. Radiographic evidence of osteoarthritis (OA; i.e., Kellgren/Lawrence grade of ≥1) in the involved knee at 5 years after injury was the primary outcome of interest. Chi‐square tests assessed differences in the presence of radiographic OA in the involved knee between subgroups at 5 years after ACL rupture. Secondary outcomes of interest included radiographic OA in the uninvolved knee, return to preinjury sport by 2 years, operative status, and clinical OA (classified using Luyten et al criteria) at 5 years.ResultsFour distinct subgroups exist after ACL rupture (younger good self‐report, younger poor self‐report, older poor self‐report, older good self‐report) with 30%, 31%, 47%, and 53%, respectively, having involved knee OA. The percentage of radiographic OA was not significantly different between the groups (P = 0.059).ConclusionThe prevalence of OA in all subgroups is highly concerning. These results suggest there are unique subgroupings of individuals that may guide treatment after ACL rupture and reconstruction by providing support for developing a patient‐centered approach.
Weight learning for ℋ∞$$ {\mathscr{H}}_{\infty } $$ stabilization of uncertain switched neural networks with external disturbance and reaction‐diffusion
Authors: Tai Weipeng , Gao Dandan , Zhao Anqi , Zhou Jianping , Wang Xiaolin 
Published: January 2023

SummaryThis paper considers the stabilization of uncertain switched neural networks with external disturbance and reaction‐diffusion. A weight learning rule that ensures the stability of the network is proposed utilizing the Lyapunov–Krasovskii functional method. Then, a useful lemma concerning the equivalence of matrix inequities is derived. With the aid of the lemma and Schur complement, a more concise existence condition on the learning rule is developed. Finally, theoretical comparisons and a numerical example are given, which show that the obtained results are extensions and improvements of an existing result.
The neglected influence of zinc oxide light‐soaking on stability measurements of inverted organic solar cells
Authors: Günther Marcella , Lotfi Soroush , Rivas Sergio Sánchez , Blätte Dominic , Hofmann Jan P. , Bein Thomas , Ameri Tayebeh 
Published: January 2023

AbstractAlthough zinc oxide (ZnO) is one of the most commonly used materials for electron transport layers in organic solar cells (OSCs), it also comes with disadvantages such as the so‐called light‐soaking issues, i.e., its need for exposure to UV light to reach its full potential in OSCs. Here, the impact of ZnO light‐soaking issues on stability measurements of OSCs is investigated. It is found that in the absence of UV light a reversible degradation occurs, which is independent of the used active layer material and accelerates at higher temperatures but can be undone with a short UV exposure. This reversible aging is attributed to the re‐adsorption of oxygen, which for manufacturing reasons is trapped at the interface of ZnO, even in an oxygen‐free environment. This oxygen can be removed with a UV pretreatment of the ZnO but at the expense of device efficiency and production that has to take place in an oxygen‐free environment. This study establishes that stability measurements of ZnO‐containing OSCs must be performed exclusively with a light source including a UV part since the usage of a simple white light source – as often reported in the literature – can lead to erroneous results.