bluuebunny/crossref_metadata_2025_split huggingface dataset:
Yeast transcription factor Msn2 binds to G4 DNA
Authors: Duy Duong Long , Kim Nayun 
Published: August 2023

Abstract
Sequences capable of forming quadruplex or G4 DNA are prevalent in the promoter regions. The transformation from canonical to non-canonical secondary structure apparently regulates transcription of a number of human genes. In the budding yeast Saccharomyces cerevisiae, we identified 37 genes with a G4 motif in the promoters including 20 genes that contain stress response element (STRE) overlapping a G4 motif. STRE is the binding site of stress response regulators Msn2 and Msn4, transcription factors belonging to the C2H2 zinc-finger protein family. We show here that Msn2 binds directly to the G4 DNA structure through its zinc-finger domain with a dissociation constant similar to that of STRE-binding and that, in a stress condition, Msn2 is enriched at G4 DNA-forming loci in the yeast genome. For a large fraction of genes with G4/STRE-containing promoters, treating with G4-ligands led to significant elevations in transcription levels. Such transcriptional elevation was greatly diminished in a msn2Δ msn4Δ background and was partly muted when the G4 motif was disrupted. Taken together, our data suggest that G4 DNA could be an alternative binding site of Msn2 in addition to STRE, and that G4 DNA formation could be an important element of transcriptional regulation in yeast.
IQGAP1 mediates the communication between the nucleus and the mitochondria via NDUFS4 alternative splicing
Authors: Papadaki Vasiliki , Erpapazoglou Zoi , Kokkori Maria , Rogalska Malgorzata Ewa , Potiri Myrto , Birladeanu Andrada , Tsakiri Eleni N , Ashktorab Hassan , Smoot Duane T , Papanikolopoulou Katerina , Samiotaki Martina , Kafasla Panagiota 
Published: August 2023

Abstract
Constant communication between mitochondria and nucleus ensures cellular homeostasis and adaptation to mitochondrial stress. Anterograde regulatory pathways involving a large number of nuclear-encoded proteins control mitochondrial biogenesis and functions. Such functions are deregulated in cancer cells, resulting in proliferative advantages, aggressive disease and therapeutic resistance. Transcriptional networks controlling the nuclear-encoded mitochondrial genes are known, however alternative splicing (AS) regulation has not been implicated in this communication. Here, we show that IQGAP1, a scaffold protein regulating AS of distinct gene subsets in gastric cancer cells, participates in AS regulation that strongly affects mitochondrial respiration. Combined proteomic and RNA-seq analyses of IQGAP1KO and parental cells show that IQGAP1KO alters an AS event of the mitochondrial respiratory chain complex I (CI) subunit NDUFS4 and downregulates a subset of CI subunits. In IQGAP1KO cells, CI intermediates accumulate, resembling assembly deficiencies observed in patients with Leigh syndrome bearing NDUFS4 mutations. Mitochondrial CI activity is significantly lower in KO compared to parental cells, while exogenous expression of IQGAP1 reverses mitochondrial defects of IQGAP1KO cells. Our work sheds light to a novel facet of IQGAP1 in mitochondrial quality control that involves fine-tuning of CI activity through AS regulation in gastric cancer cells relying highly on mitochondrial respiration.
Prediction of G4 formation in live cells with epigenetic data: a deep learning approach
Authors: Korsakova Anna , Phan Anh Tuân 
Published: August 2023

Abstract
G-quadruplexes (G4s) are secondary structures abundant in DNA that may play regulatory roles in cells. Despite the ubiquity of the putative G-quadruplex-forming sequences (PQS) in the human genome, only a small fraction forms G4 structures in cells. Folded G4, histone methylation and chromatin accessibility are all parts of the complex cis regulatory landscape. We propose an approach for prediction of G4 formation in cells that incorporates epigenetic and chromatin accessibility data. The novel approach termed epiG4NN efficiently predicts cell-specific G4 formation in live cells based on a local epigenomic snapshot. Our results confirm the close relationship between H3K4me3 histone methylation, chromatin accessibility and G4 structure formation. Trained on A549 cell data, epiG4NN was then able to predict G4 formation in HEK293T and K562 cell lines. We observe the dependency of model performance with different epigenetic features on the underlying experimental condition of G4 detection. We expect that this approach will contribute to the systematic understanding of correlations between structural and epigenomic feature landscape.
Introduction
Authors: Reside Douglas L. 
Published: August 2023

Abstract
Many fans of musical theatre first encounter musicals not via live stage performances but through cast recordings, published scripts, and video recordings. These media shape the musical theatre repertory and fix audience expectations of the titles in the repertory. Those elements of a musical that are most fluid are often those not fully documented in the most popular recording or recordings of the title. This introduction first attempts to define the repertory of musical theatre in the early 21st century by surveying the titles that are most frequently produced at resident theatres across the country and then summarizes the ways in which the various elements of musicals have been seen as fixed or fluid by previous editors and scholars.
Printing the Musical
Authors: Reside Douglas L. 
Published: August 2023

Abstract
Although printing in the West developed in the fifteenth century, new printing technologies perfected in the nineteenth and twentieth centuries meant that texts and music could be printed more rapidly and cheaply. This led to an increased willingness of publishers to experiment with printing for niche markets (such as readers of musical theatre libretti). As the printing of libretti became more common in the early twentieth century, the musical theatre libretto, often little more than a functional and disposable scaffolding in the nineteenth century, became respected enough to be considered “drama” and win Pulitzer Prizes in the twentieth. As a result, the libretto became part of what was signified by the title of a musical and could not be dramatically changed without subverting audience expectation.
Recording the Musical
Authors: Reside Douglas L. 
Published: August 2023

Abstract
Audio recording, reproduction, and distribution technologies developed in the nineteenth and twentieth centuries worked to “fix” the program of a musical from a relatively fluid set of interchangeable songs into an increasingly stable score. As new audio technologies emerged, the market for re-releases of content available on earlier formats helped to establish a musical theatre repertory as the titles that were considered most “important” were converted to the new formats most quickly. As the commercial market for recorded music grew, musicals that could be easily appreciated on the basis of the recording alone entered the repertory more quickly than those that depended on the unrecorded or visual elements of a production.
The Musical as Moving Image
Authors: Reside Douglas L. 
Published: August 2023

Abstract
As with audio recordings, musicals that could be appreciated on film quickly entered the repertory. Further, changes made for filmed versions became part of audience expectations even when these changes were not incorporated into the texts licensed for stage performance. Starting in the mid-1970s, growing interest in recording and broadcasting recorded theatre on cable and on Public Television led to broadcast of several of the musicals of Stephen Sondheim. These recordings helped to establish Sondheim as a master artist, and the appearance of musical theatre on PBS alongside broadcasts of opera and serious non-musical theatre helped to establish the musical as an important American art form worthy of critical attention.
Licensing the Musical
Authors: Reside Douglas L. 
Published: August 2023

Abstract
Since the late nineteenth century, commercial enterprises have managed the legal licensing of musicals for new amateur and regional productions. These companies work with the artists they represent to create materials designed to support new productions in environments that may be very unlike the stage on which the musical first premiered. To support new, low-budget productions, licensing houses once rented costumes and set pieces along with scripts and scores. Although this practice was largely abandoned by the mid-twentieth century, some companies now provide access to digital files that include projection designs, video choreography instruction, and even orchestral backing tracks that can be dynamically controlled by a music director. Current technology has made it possible to fix nearly every element of a production except the performances of the amateur actors.
Rom com Revamped
Authors: Rao Maithili 
Published: August 2023

Abstract
Romance, the essence of Sringara rules in popular cinema but finds new expression in the Bollywood romcom of the new millennium. It released the love story from the suffocating grip of conservatism and turned it into a caper about relationships, successfully Indianizing a winning Hollywood formula that was petering out. It has come a long way since the first commercial success (Hum Tum, 2004 inspired by When Harry Met Sally, 1989) and continues to be rewritten for the millennial generation with large production houses to back it. Unlike love stories of the 1990s (Dilwale Dulhania Le Jayenge, Kuch Hota Hai, and others) which tried to depict romance in a globalized India and appease ‘traditional values’, the romcom broke with conservative norms about love, marriage, gender, and relationships. It foregrounded the female protagonist as a woman with agency and substance and not merely an object of male desire. The genre relied on the female star (Kareena Kapoor, Dipika Padukone, Anushka Sharma) and has accorded her space in a male dominated Bollywood pantheon. Though notable romcoms have been written and directed by men, heroes are aware of their flaws and emotional vulnerabilities while heroines are self-aware and confident. Contemporary attitudes to love, friendship, premarital sex, and live-in relationships are explored from the point of view of women.
Non-conformists Are the New Cool
Authors: Rao Maithili 
Published: August 2023

Abstract
The millennial woman is a non-conformist who charts her path and refuses to play out conventional scripts assigned by society and its institutions, including the family. Films portray a slew of expressions of defiance from diverse social settings. Actors like Vidya Balan, Kangana Raunat, Taapsee Panu, Deepika Padukone, Kalki Koechelin, Alia Bhatt have all broken stereotypes with elan. Post globalization, authoritarian families continued to shelter women from new social norms. Bollywood non-conformists upset conventions around marriage, sex, and relationships be it in the neighbourhoods of Delhi or in the Haryana heartlands or Chennai. These leading ladies surprise us with their choices. Margarita with a Straw (2014) debunks the myth that a physically challenged woman feels no sexual desire. Safeena (Gully Boy, 2019) a fiery young woman defies the constraints imposed by her family and embarks on a journey of self-determination. Amu (Thappad, 2020) calmly decides to withstand family and societal pressure to end her marriage over a ‘mere’ slap from her husband. Non-conformism doesn’t only mean defiance. Vidya Balan, with her easy manner and self-confidence, has portrayed characters that are celebrated for their unapologetic use of the body and sexuality as a means of achieving power and self- definition within a patriarchal framework (The Dirty Picture, 2011; Ishqiya, 2010). Unlike the gritty Parallel Cinema of the 70s/80s, the new non-conformism adheres to a mainstream format that relies on the ‘right’ actress to deliver its punch and engage the audience. As post-feminist portrayals they foreground individual choices rather than larger ideologies.
The Subversives
Authors: Rao Maithili 
Published: August 2023

Abstract
Anurag Kashyap and Tigmanshu Dhulia’s iconoclastic remakes of classics Dev Das and Sahib Bibi Aur Gulam (Dev D, 2009; Sahib Biwi Aur Gangster, 2011) gesture to the past but are edgy stories that capture the zeitgeist of the millennium. Both narratives relocate from colonial Bengal to contemporary Punjab and rural UP which allows for a subversion of plot and characters. In Dev D the angst-ridden hero of the classic is recast as a self-destructive egoist with a sense of entitlement. Unlike the coy Paro of the classic, Kashyap’s heroine (Mahi Gill) is a passionate woman who owns her desire and need for sexual gratification. The women (Paro and Chanda) in Dev D are centred and practical in contrast to the escapist Dev (Abhay Deol) who is lost in his addictions. Chandramukhi the lovelorn tawaif of the older versions is discarded and Chanda (Kalki Koechlin) is a determined young woman planning for a better future. Unlike the tragic ending of the classic, the film ends on a note of hope. In Guru Dutt’s Sahib Bibi Aur Ghulam (1962) Meena Kumari created the unforgettable tragic heroine Choti Bahu who longs for intimacy with her pleasure-seeking Zamindar husband. Dhulia subverts this character to create Choti Rani in rural UP. Drink and cigarette in hand, she charts her course in a power game where men are pawns. Unlike Choti Bahu, Choti Rani refuses victimhood and instead uses her position to avenge humiliations. These millennial versions make space for dynamic women who express themselves fearlessly.
Unparalleled Poetry
Authors: Grosser Emmylou J. 
Published: August 2023

Abstract
This book disentangles biblical Hebrew poetry from more than 250 years of scholarship dominated by metrical assumptions and the problematic notion of parallelism; the cognitive approach offered in replacement provides an account of the free-rhythm versification system of biblical poetry that is oriented toward how poetic structure can be heard and perceived. Drawing from the cognitive poetics work of Reuven Tsur, the book argues that the poetic line emerges in the cognitive experience of the listener/reader. The “lines” of biblical poetry are reconceptualized not as linear and parallel but as diverse segments that make up shapes or figures, the line-groupings of biblical poetry. The line emerges in biblical poetry in the part-whole mental organization of the line in relation to the line-grouping, which is accounted for through the Gestalt principles of perception. The Gestalt principles provide the structural potential of biblical Hebrew poetry, which is distinct from any particular aspect of language but potentially draws from any aspect of it. Additionally, the Gestalt principles account for how the lines and line-groupings come together to form larger integrated wholes of stanzas and poems. This cognitive approach to biblical poetry accounts for the wide diversity of lines and poems in the Hebrew Bible and illuminates both the structures of biblical poetry and the artistry of potential effects. It also addresses the issues of rhythm and the so-called qinah meter, line lengths and the immediate memory constraint, and the relationship between prose and poetry in the Hebrew Bible.
Conclusion: Unparalleled Poetry
Authors: Grosser Emmylou J. 
Published: August 2023

Abstract
Chapter 9 revisits Psalm 23 and the two problems it raised at the beginning of this book: What are the lines of biblical poetry, and why does it even matter? This chapter walks through the line structure of Psalm 23 and establishes that the psalm is a composition in verse. It then demonstrates how the mental organization of the lines affects how the message of the work is heard and experienced. The chapter summarizes what this book has contributed to replace parallelism and metrical approaches: a coherent and unified free-rhythm versification system of lines fitting to lines that is theoretically plausible and simple, though contextually complex. This cognitive approach accounts for the wide diversity of biblical lines and poems and illuminates not just the structures of biblical poetry, but also the artistry of potential effects. It has implications for further research in Ugaritic as well as comparative literature approaches to parallelism.
Beazley, Daubert, and the Burden of Proof
Authors: Stewart Peter 
Published: August 2023

Abstract
This chapter deals with the relationship between art history and a form of forensic “connoisseurship.” The discussion deals with the so-called Morellian analysis used for over a century to attribute anonymous paintings to the hands of particular artists. The focus here is especially on the career of Professor Sir John Beazley (1885–1970), who dedicated his life to attributing ancient Athenian pot-paintings in this way. The method has long been associated with forensic approaches which emerged at around the same time in the late nineteenth century. These are still in use today alongside more modern (and often equally controversial) techniques. In contrast to art history, the forensic application of connoisseurship carries very high stakes. The chapter examines the ways in which the courts in the UK and United States, motivated by the imperative to rely on reasonable levels of confidence rather than scientific proof, seek to contain uncertainty arising from subjective connoisseurship.
The Frontiers of Corporate Food in Egypt
Authors: Dixon Marion W. 
Published: August 2023

Abstract
Corporations have had a growing role in agriculture and food around the world. The Frontiers of Corporate Food in Egypt details the development and growth of a corporate agri-food system in Egypt. This system includes food processing and an animal protein complex largely for corporate consumer markets in the country—from street kiosks to fast food outlets to hypermarkets—and fresh fruits and vegetables largely for export. The book demonstrates the importance of reclaimed lands, or frontiers, for the development and growth of the corporate agri-food system from the 1980s through the 2011 popular uprising. Various forces, including multiple threats from plant and animal diseases (the Avian flu, especially) have pushed and pulled agribusiness to new lands. This system’s growth has also rested on imports and contract farming. As a result, dependence on food imports has grown. What agriculturalists grow has changed toward processing vegetables and animal protein, and what Egyptians eat has changed toward foods/drinks high in unhealthy fats, sugars, and sodium. Through mixed-methods research in Egypt between 2008 and 2012, this book shows how the growth of corporate food has contributed to growing food insecurity and to multiplying threats to public health from chronic and infectious diseases.
Food Crises and Revolt
Authors: Dixon Marion W. 
Published: August 2023

Abstract
Chapter 2 details the causes of the twin crises of 2007–08 and 2011, when world food prices rose sharply. It shows how the growth of a corporate agri-food system in Egypt contributed to the vulnerabilities of population groups within the country to the price shocks. Instead of addressing the causes of world price volatility, multilateral organizations, think tanks, corporate media, scholars, and government agencies alike began to wrongly blame the resulting food insecurity on consumer food subsidies in Egypt and elsewhere. Food (and other) subsidies have long been the ire of neoliberals, and they gained renewed attention in the intercrisis period (2008–2011). By 2011, following the uprisings throughout the Middle East and North Africa region, the neoliberal consensus changed from reforming subsidies to replacing them with cash transfers.
The Frontier and Export Plantation Economy of the Long Nineteenth Century
Authors: Dixon Marion W. 
Published: August 2023

Abstract
Chapter 5 introduces food regime analysis and details the colonial-era food regime of the long nineteenth century (c. 1780s–1914). European imperial states extended colonial rule to offshore production of foodstuffs and industrial inputs (e.g., cotton, indigo) in peripheral states, which also became markets for European finished imports. The chapter situates commodity frontiers in food regime analysis, and the argument is that a frontier of reclaimed lands in the Egyptian state was a condition for participation in the colonial-era food regime. Land reclamation provided the initial conditions for capital formation and development in land. So significant was land reclamation in Egypt, under the Ottomans and then the British, that the Nile Delta itself greatly expanded. A typology of frontiers in Egypt, from the long nineteenth century to the early twenty-first century, is also introduced.
Post-Colonial Frontier Making?
Authors: Dixon Marion W. 
Published: August 2023

Abstract
Chapter 6 details the second of three frontiers in modern Egypt: state land reclamation, or the state frontier. This frontier began to develop in post-1922 Egypt and under the food aid regime, which replaced the colonial-era food regime in the interwar period. The state frontier was devoted to land redistribution and state collective farming, both for subsistence and national urban markets. The chapter shows how state land reclamation under the Nasser administration informed the character of the third type of frontier, the desert frontier, beginning in the 1970s. Land reclamation developed a distinct character that remains; that is, land reclamation became a way for society and polity to solve a host of social problems from capitalist development. Also, when state reclaimed lands were sold to investors, agribusiness came to rely on state reclamation communities (of smallholders). One such community and its relationship to the corporate agri-food system today are highlighted.
Democracy’s Interwar Crisis as Learning Experience
Authors: Corduwener Pepijn 
Published: August 2023

Abstract
If we want to understand why the people’s party could resurface as the hegemonic political model for postwar Western Europe, the period between the mid-1930s and mid-1940s is essential. This chapter turns to this decade and shows how the experiences with both the failures of the mass party in the Interwar era and with authoritarian one-party regimes contributed to an unexpected revival and re-evaluation of the idea of the people’s party. For many leading politicians, both experiences were learning experiences on how to rethink and reform party politics in the future. They often concluded that democracy required people’s parties in order to be sustained. This chapter tracks the writings and experiences of some of these key politicians like Alcide de Gasperi and Konrad Adenauer, Hendrik de Man, and Léon Blum and shows how they lived through this transformative period that led to a rethinking of the role and responsibilities of parties in modern democracy.
The Challenge of 1973 and Governability as Leading Purpose
Authors: Corduwener Pepijn 
Published: August 2023

Abstract
The challenge of 1968 did not stand on itself. It was soon followed by another major blow to the postwar model of democracy, one that targeted in particular its material base and the social and economic paradigms which had sustained it: the 1973 Oil Crisis. This chapter shows how party leaders sought to confront the economic crisis that followed it and shows how it affected their understanding of the function of the people’s parties in the democratic system. Sometimes motivated by the memories of the 1930s, party leaders felt that the people’s parties could distinguish themselves most of all in these uncertain times by providing good and efficient government. They could provide, in the catchword of the time, governability of what seemed to them unruly societies and an ungovernable state. This growing emphasis on governability implied a rather radical change of direction for the people’s parties, which upset some of the careful balances on which they had based their success. By the end of the 1980s, many people inside and outside the people’s parties started to criticize this turn of people’s parties as the gap between their electorate and those in power seemed to become ever wider.