bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Hydraulic Fracture Geometry Inversion Model Based on Distributed-Acoustic -Sensing Data
Authors: Hu Xiaodong , Tu Zhiyong , Zhou Fujian , Zhao Yang , Li Xintong , Zhou Qianlong , Gou Xiaoyan 
Published: January 2023

Summary
Distributed-acoustic-sensing (DAS) data have been widely used to monitor multifracture hydraulic fracturing. Interpreting hydraulic fracture geometry (width and length) using DAS data is a popular topic of current research. However, the previous study can only estimate the fracture width near the offset well from single low-frequency DAS (LF-DAS) data. Due to the multiplicity problem, no study was attempted to characterize fracture lengths from DAS data. In this paper, we propose a new model to inverse the fracture length and width over treatment time from multiple sources of data [LF-DAS, high-frequency DAS (HF-DAS), and injection rate data]. First, HF-DAS waterfall plots of the treatment well and injection rate curves are aligned to determine the volume of fluid injected into each fracture. LF-DAS data along the offset well are related to fracture width by the Green function. The fracture length and width are determined by combining the Green function and fluid volume constraint. Second, the Picard and the least-squares methods are used to improve the robustness of the model computation. The inversion model is validated by a fracture propagation case generated by the displacement discontinuity method (DDM). In addition, the effects of the distance between the fiber and the wellbore, spatial sampling spacing, and fracture spacing on the computational stability of the inversion model are discussed. By combining DAS data and other monitoring data (e.g., inject rate) from treatment or offset well, the fracture length and width with treatment time can be accurately estimated. Results of fracture geometry interpretation can optimize fracture design and help improve production efficiency.
Anisometropia in Children in Shandong, China: A Prospective Longitudinal Study
Authors: Jing X , Yuanyuan Hu , Xiuyan Zhang , Qingmei Tian , Qiuxin Wu , Tailiang Lu , Jike Song , Hongsheng Bi 
Published: January 2023

Abstract
Objectives: To determine the characteristics of anisometropia in children.
Design: This is a prospective study of Chinese school children. A total of 1474 children (4-15 years old) from 12 schools of Guanxian county (Shandong, China) were enrolled between December 2018 and June 2020 through cluster sampling. The changes of differences in spherical equivalent refraction (SER), axial length (AL) in different anisometropia, and the increases of SER, AL in new-onset anisometropia, non-anisometropia were evaluated over 18 months.
Results: Among 1474 children, 1347 (91.4%) children had a full set of data at the first visit. The prevalence of SER anisometropia was 8.5% at the first visit, and increased to 15.1% at the second visit (χ2=27.077, p<0.001). Among children with SER anisometropia (n=110), 25.45% (28/110) experienced an increase in anisometropia ≥0.5 D, whereas 20.91% (23/110) experienced a decrease in anisometropia ≥0.5 D, and 53.64% (59/110) with anisometropia were stable. For L eyes, the increase of SER was greater in the new-onset anisometropia than that in the non-anisometropia (p<0.05); for H eyes, the increases of SER in the two groups were not significantly different (p>0.05).
Conclusions: The prevalence of anisometropia increased over time. Nearly half of children with anisometropia were unstable. The unilaterally greater rate of SER increase in children could be associated with the development of anisometropia.
Neuronal growth on high-aspect-ratio diamond nanopillar arrays for biosensing applications
Authors: Losero Elena , Goblot Valentin , Pezzoli Maurizio , Babashah Hossein , Jagannath Somanath , Galland Christophe , Quack Niels , Lashuel Hilal 
Published: January 2023

Abstract
Monitoring neuronal activity with simultaneously high spatial and temporal resolution in living cell cultures is crucial to advance understanding of the development and functioning of our brain, and to gain further insights in the origin of brain disorders. While it has been demonstrated that the quantum sensing capabilities of nitrogen-vacancy (NV) centers in diamond allow real time detection of action potentials from large neurons in marine invertebrates, quantum monitoring of mammalian neurons (presenting much smaller dimensions and thus producing much lower signal and requiring higher spatial resolution) has hitherto remained elusive. In this context, diamond nanostructuring can offer the opportunity to boost the diamond platform sensitivity to the required level. However, a comprehensive analysis of the impact of a nanostructured diamond surface on the neuronal viability and growth was lacking. Here, we pattern a single crystal diamond surface with large-scale nanopillar arrays and we successfully demonstrate growth of a network of living and functional primary mouse hippocampal neurons on it. Our study on geometrical parameters reveals preferential growth along the nanopillar grid axes with excellent physical contact between cell membrane and nanopillar apex. Our results suggest that neuron growth can be tailored on diamond nanopillars to realize a nanophotonic quantum sensing platform for wide-field and label-free neuronal activity recording with sub-cellular resolution.
Bipolar argumentative semantics for t-norm based fuzzy logics
Authors: Corsi Esther Anna 
Published: January 2023

Abstract
In this paper, we introduce argumentative sound and complete semantics for the three main t- norm based fuzzy logics, Łukasiewicz (Ł), Goedel (G) and product logic (Π). We understand the arguments as complex entities and instantiate the link between the support and the claim of an argument with the three t-norm consequence relations corresponding to Ł, G and Π. The argumentative frameworks considered are bipolar frames. Thus, the arguments interact through two different relations: the attack and the support relation. By introducing argumentative principles defined over the two relations and using the notion of argumentative immunity, the semantics are recovered.
A novel incision technique of totally implanted venous access port in upper arm for patients with breast cancer
Authors: Song Xue , Chen Shengying , Dai Yan , Sun Yang , Lin Xiaojie , He Jiafa , Chen Qianjun , Xu Rui 
Published: January 2023

Abstract
Background

Totally implanted venous access port (TIVAP) in upper arm is a safe and cost-effective vascular access device and is widely used in breast cancer patients. Traditional tunneling technique increase the operation time and unsatisfied cosmetic effect so we explore the feasibility, cosmetic effect, and complications of an upper arm port with a novel incision in this retrospective study.

Methods

We reviewed 489 cases of totally implantable venous access port implantation in the upper arm with two types of incision in our center from 1 January 2018 to 30 January 2022. The patients were divided in to two different incision groups including puncture site incision group(n = 282) and conventional tunneling group(n = 207). The comparison of the results were collected between the two groups and contributing factors were analyzed for major complications.

Results

A total of 489 patients were successfully implanted arm port with puncture site incision technique(n = 282, 57.7%) and conventional tunneling technique(n = 207, 42.3%). The average operation time of two types of incision was (36.5 ± 15) min in the puncture site incision group and (55 ± 18.1) min in the tunnel needle group ( P < 0.05). In terms of complications,33 catheter-related complications occurred (6.4%), including 9 cases of infection, 15 cases of catheter-related thrombosis and 7 cases of skin exposure. 14 patients in the puncture site incision group developed complications compared with 17 in the traditional incision group.There were no significant differences between the two groups in terms of overall complication events (5.0% and 8.2%, p = 0.145) while the same result were found in each complication event. Weight, total cholesterol and diabetes were found to be associated with device-related infections in univariate Cox proportional hazard regression models. Diabetes was found to be associated with device-related infections in multivariate analysis while hypertension was associated with thrombosis.
Conclusions: The methods of puncture site incision improves the efficiency of the procedure and provide a better cosmetic appearance compared with traditional tunnel needle technique. It is a novel technique and preferable for totally implantable venous access port implantation in upper arm with comparable overall rate of complication for patients with breast cancer. It is worthy of being used and promoted in clinical research.
Comparative effects of epidural steroid injections on disc bulging and disc protrusion in patients with discogenic low back pain
Authors: Çetin Eyüp , Şah Volkan , Zengin İrfan , Arabacı Özkan , Akyol Mehmet Edip , Yücel Murat 
Published: January 2023

Abstract
Objective
In this study, we aimed to examine the effect of epidural steroid administration (ESI) on disc bulging and disc protrusion in patients with discogenic low back pain.
Materials and Methods
The prospective randomized study reviewed medical records of 71 patients with discogenic low back pain who were radiologically proven as disc bulging and disc protrusion with or without radicular pain and did not require surgery at Neurosurgery Department between June 2021 and June 2022. All the patients underwent ESI and attended regular follow-up visits for a period of 6 months. Visual Analogue Scale (VAS) and Oswestry Disability Index (ODI) scores were assessed before the procedure, one week after the procedure, one month after the procedure, and six months after the procedure.
Results
There was no significant difference between patients with disc bulging and disc protrusion in terms of demographic characteristics. In both groups, both VAS and ODI scores showed a significant decrease in the post-procedure period compared to the pre-procedure period. However, there was no significant difference between the two groups with regard to the reduction rate between post-procedure 1st week VAS scores and pre-procedure VAS scores.
Conclusion
The results indicated that lumbar interlaminar steroid injection is an effective treatment for disc bulging and discogenic pain due to protrusion and that both groups benefited from ESI administration. Additionally, except for the first week of injection, relief due to the use of epidural steroids was observed to be greater in the Disc Protrusion group compared to the Disc Bulging group.
IL-17A facilitates entry of autoreactive T-cells and granulocytes into the CNS during EAE
Authors: Zimmermann Julian , Nitsch Louisa , Krauthausen Marius , Müller Marcus 
Published: January 2023

Abstract
Interleukin-17A plays a crucial role in multiple sclerosis and other autoimmune diseases. Although the link between IL-17 and disease activity has been clearly demonstrated, the precise function of this cytokine remains elusive. Here, we investigated the function of astrocyte targeted IL-17A production in GF/IL17 transgenic mice during EAE. In particular, IL-17A is importantduring disease induction. In mice with transgenic IL-17A production, disease occurs earlier and peak disease is more severe, whereas remission is unimpaired. IL-17A synthesis is associated with increased infiltration of granulocytes into the CNS and microglial activation. Moreover, IL-17A synthesis allows induction of MOG-EAE without the additional administration of the co-adjuvant pertussis toxin. Examination of double transgenic GF/IL17 2D2 mice revealed that, in addition, local IL-17A production facilitates spontaneous infiltration of immune cells into the CNS in mice expressing a MOG-specific T-cell receptor. Overall, we provide evidence for a crucial effect of IL-17A in the induction phase of EAE, facilitating the infiltration of granulocytes and autoreactive T cells into the CNS.
Biosynthesis of polyene antibiotics and sterols under the action of exogenous β-sitosterol by Streptomyces netropsis IMV Ac-5025
Authors: Loboda Mariia , Biliavska Liudmyla 
Published: January 2023

Abstract
Unexplained aspects of the biosynthetic capacity of Streptomyces netropsisIMV Ac-5025 were studied. Correlations in the biosynthesis of polyene antibiotics with other biological active substance by the producer were found for the first time. Exogenous β-sitosterol caused an increase of polyene antibiotics biosynthesis and their excretion from the cells into culture liquid. Their sum was raised 4.5-fold in biomass and 2.5-fold in culture liquid under the action of 10 μg/mL of β-sitosterol. Biomass accumulation was almost doubled under the action of 5 μg/mL of exogenous substance in the synthetic nutrient medium and 1.5-fold – in organic. Squalene, ergosterol, cholesterol, stigmasterol, β-sitosterol, and 24-epibrasinolide were accumulated in producer cells. Their sum was ranged from 1.753 to 4.750 mg/g ADB and was increased 2.7-fold under the action of 0.25 μg/mL of β-sitosterol. These results are important for understanding the complex relationships of metabolic pathways in streptomycetes cells.
Texture Feature Analysis of MRI-ADC Images to Differentiate Glioma Grades Using Machine Learning Techniques.
Authors: Vijithananda Sahan M. , Jayatilake Mohan Mohan L. , Gonçalves Teresa C. , Hewavithana Badra , Rato Luis M. , Weerakoon Bimali S. , Kalupahana Tharindu D. , Silva Anil D. , Dissanayake Karuna 
Published: January 2023

Abstract
Background: Apparent Diffusion Coefficient (ADC) of Magnetic Resonance Imaging (MRI) is an indispensable imaging technique in clinical neuroimaging that quantitatively assesses the diffusivity of water molecules within tissues using Diffusion-weighted imaging (DWI). This study focuses on developing a robust Machine Learning (ML) model to predict the aggressiveness of gliomas according to World Health Organization (WHO) grading by analyzing patients’ demographics, higher-order moments, and Grey Level Co-occurrence Matrix (GLCM) texture features of ADC.
Methods: A population of 722 labeled MRI-ADC brain image slices from 88 human subjects was selected, where gliomas are labeled as glioblastoma multiforme (WHO-IV), high-grade glioma (WHO-III), and low-grade glioma (WHO I-II). Images were acquired using 3T-MR systems and a region of interest (ROI) was delineated over tumor areas. Skewness, kurtosis, and statistical texture features of GLCM (mean, variance, energy, entropy, contrast, homogeneity, correlation, prominence, and shade) were calculated using ADC values within ROI. The ANOVA f-test was utilized to select the best features to train an ML model. The data set was split into training (70%) and testing (30%) sets. The train set was fed into several ML algorithms and selected most promising ML algorithm using K-fold cross-validation. The hyper-parameters of the selected algorithm were optimized using random grid search technique. Finally, the performance of the developed model was assessed by calculating accuracy, precision, recall, and F1 values reported for the test set.
Results: According to the ANOVA f-test, three attributes; patient gender (1.48), GLCM energy (9.48), and correlation (13.86) that performed minimum scores were excluded from the dataset. Among the tested algorithms, the random forest classifier(0.8772±0.0237) performed the highest score and selected to build the ML model which was able to predict tumor categories with an accuracy of 88.14% over the test set.
Conclusion: The study concludes that the developed ML model using the above features except for patient gender, GLCM energy, and correlation, has high prediction accuracy in glioma grading. Therefore, the outcomes of this study enable to development of advanced tumor classification applications that assist in the decision-making process in a real-time clinical environment.
Ssc-miR-221-3p regulates melanin production in Xiang pigs melanocytes by targeting the TYRP1 gene
Authors: Yuan Wei , Qin Hai , Bi Huan , Zhao Depeng , Zhang Yiyu , Chen Wei 
Published: January 2023

Abstract
Background
MicroRNAs (miRNAs) are small non-coding RNAs of endogenous origin that down-regulate gene expression. An increasing number of studies have confirmed that miRNAs play an important role in mammalian hair color production, and the TYRP1 gene, a member of the tyrosine family, is also an important candidate gene affecting melanogenesis. The aim of this study was to screen genes and miRNAs that affect melanin in Xiang pigs by transcriptome sequencing, and to validate through experiments whether the screened genes and miRNAs have a targeted regulatory relationship with each other and whether they can jointly affect melanin production in Xiang pigs.
Results
17 miRNAs and 1230 genes were significantly differentially expressed in the black and white skin tissues of Xiang pigs(P < 0.05), based on which the candidate miRNA-221-3p for melanin formation and its target gene TYRP1 were screened. TYRP1 gene, as a member of the TYR gene family, was evolved from the TYR gene through chromosome segmental duplication, and the gene function was highly conserved throughout the evolutionary process. overexpression of TYRP1 gene significantly increased the expression of TYR, TYRP1 and DCT genes༈P < 0.01༉, which in turn increased the relative content of melanin, and TYRP1-siRNA significantly decreased the expression of TYR, TYRP1, and DCT genes in Xiang pig melanocytes༈P < 0.01༉, which in turn decreased the relative melanin content. Validation of the targeted binding relationship between ssc-miR-221-3p and TYRP1 gene, after transfection of porcine melanocytes with ssc-miR-221-3p mimic, the expression of ssc-miR-221-3p was significantly up-regulated༈P < 0.01༉, TYR, TYRP1, and DCT genes were significantly down-regulated at both mRNA and protein levels༈P < 0.01༉, and melanin content in cells was significantly reduced༈P < 0.01༉.
Conclusion
The TYRP1 gene can affect melanogenesis in melanocytes of the Xiang pigs, and ssc-miR-221-3p targets the TYRP1 gene to affect melanogenesis in melanocytes of the Xiang pigs.
Discovery of 3,7-dimethoxyflavone that inhibits liver fibrosis based on dual mechanisms of antioxidant and inhibitor of activated hepatic stellate cell
Authors: Park Hyomin , Lee Eun Ju , Moon Dodam , Cha Areum , Yun Hyunji , Hwang Injoo , Kim Hyo-Soo 
Published: January 2023

Abstract
The important pathway toward liver fibrosis is the TGF-β1-induced activation of hepatic stellate cells (HSCs). To discover chemicals to inhibit liver fibrosis, we screened 3,000 chemicals using cell array system where human HSCs line LX2 cells are activated with TGF-β1. We discovered 3,7-dimethoxyflavone (3,7-DMF) as a chemical to inhibit TGF-β1-induced activation of HSCs.
In the thioacetamide (TAA)-induced mouse liver fibrosis model, 3,7-DMF treatment via intraperitoneal or oral administration prevented liver fibrosis as well as reversed the established fibrosis in the separate experiments. It also reduced liver enzyme elevation, suggesting protective effect on hepatocytes because it has antioxidant effect. Treatment with 3,7-DMF induced antioxidant genes, quenches ROS away, and improved the hepatocyte condition that was impaired by H2O2 as reflected by restoration of HNF-4α and albumin. In the TAA-mouse liver injury model also, TAA significantly increased ROS in the liver which led to decrease of albumin and nuclear expression of HNF-4α, increase of TGF-β1 and hepatocytes death, accumulation of lipid, and extra-nuclear localization of HMGB1. Treatment of 3,7-DMF normalized all these pathologic findings and prevented or resolved liver fibrosis.
In conclusion, we discovered 3,7-DMF that inhibits liver fibrosis based on dual actions; antioxidant and inhibitor of TGF-β1-induced activation of HSCs.
Design of Uniplanar Compact Electromagnetic Band Gap (UC-EBG) for Massive MIMO 5G C-Band Antenna
Authors: Sandi Efri , Maruddani Baso , Yuliatmojo Pitoyo , Saputra Ari Alifa 
Published: January 2023

Abstract
This study aims to reduce the mutual coupling and envelope correlation coefficient (ECC) parameters of massive MIMO antennas. This parameter is important to support the performance of MIMO antennas in increasing high-speed data transmission. The observations in this study were carried out at a frequency of 3.5 GHz as one of the 5G frequency bands by using a comparative study method between the performance of the addition of Uni-planar Compact EBG (UC-EBG) and without using UC-EBG. The study used a massive MIMO 64 element antenna design with the addition of a specially designed UC-EBG surrounding the antenna element. The parameters of simulation and measurement results are compared with conventional MIMO antenna performance (without UC-EBG). Simulation results and antenna measurements show that the addition of the UC-EBG structure has succeeded in reducing the mutual coupling by 1.23 dB and improve the ECC parameter by 0.61. In addition, the UC-EBG structure can improve the performance of return loss and massive MIMO antenna VSWR. These results indicate that the addition of a special UC-EBG design around the MIMO patch antenna proposed in this study has an important contribution in increasing the isolation of massive MIMO antennas and can be the basis for the development of massive MIMO microstrip antennas.
H2-reduced phosphomolybdate promotes room-temperature aerobic oxidation of methane to methanol
Authors: Wang Sikai , Fund Victor , Hülsey Max , Liang Xiaocong , Yu Zhiyang , Chang Jinquan , Folli Andrea , Lewis Richard , Hutchings Graham , He Qian , Yan Ning 
Published: January 2023

Abstract
The selective partial oxidation of methane to methanol using molecular oxygen represents a long-standing challenge in the field of catalysis, inspiring extensive study for many decades However, to date considerable challenges still prevent large-scale production via the aerobic route. Herein, we report a Pd-containing phosphomolybdate catalyst (Pd/CsPMA), which, after activation by H2 converts methane and O2 almost exclusively to methanol at room temperature. The highest activity reached 67.4 µmolgcat−1h− 1. Pd enables rapid H2 activation and H spillover to phosphomolybdate for Mo reduction, while facile O2 and subsequent methane activation occurs on the reduced phosphomolybdate sites. Phosphomolybdate maintained its Keggin-type structure during the reaction, and the catalyst is reused 4 times without losing activity. The work reveals the underexplored potential of Mo-based catalyst for aerobic methane oxidation and highlights the importance of regulating the chemical valance state to construct methane active sites.