bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of the compatibility of EUCAST Direct Rapid Antimicrobial Susceptibility Test (RAST) Method Results with Automated Systems in Positive-Signaling Blood Culture Bottles
Authors: Aydemir MD Özlem , Şahin MD Elif Özözen , Köroğlu MD Mehmet 
Published: July 2023

Abstract
The aim of this study is to compare the RAST results with the Vitek 2 automatic system and evaluate its effectiveness. Total of 76 strains, including anonymous 15 Pseudomonas aeruginosa, 24 Escherciae coli, 16 Klebsiella pneumoniae, 6 Staphylococcus aureus, 11 Enterococcus faecalis, 1 Streptococcus pneumoniae, 3 Acinetobacter baumanii, found in the laboratory culture collection was included in the study. Rapid Antimicrobial Susceptibility Test (RAST) was performed in accordance with European Committee on Antimicrobial Susceptibility Testing (EUCAST) recommendations. A 10 µg ceftazidime disk was used for the detection of Extended Spectrum Beta-Lactamase (ESBL) by the RAST method. After incubation, it was interpreted as susceptible (S), resistant (R) and technical uncertainty area (ATU) according to EUCAST RAST v.1.1 breakpoint tables. Categorical results in 4, 6, 8 and 20 hours incubation were compared with vitek 2 automated system results. 581 disc diffusion studies were performed for all strains. Measurable zone diameter of inhibition occurred in 444 (76.4%) disc studies. The agreement between the results of the studies evaluated as sensitive and resistant by RAST with the results of the Vitek 2 automated system was found to be 98.4%. Compatibility with Vitek 2 automated system at the fourth hour was 98.1%; it was 97.9% at the sixth hour and 100% at the eighth hour. Our study shows that the RAST results are quite compatible with the conventional method. Therefore, although there are difficulties in routine laboratory practice, the results obtained with RAST show that it will provide rapid evaluation of empirical antibiotic therapy in bloodstream infections.
SupOU-based and Related Fractal Activity Time Models for Risky Assets with Dependence
Authors: Leonenko Nikolai N. , Liu Anqi , Shchestyuk Nataliya 
Published: July 2023

Abstract
We propose several new models in ecophysics known as the Fractal Activity Time Geometric Brownian Motion (FATGBM) models with Student marginals. We summarize four models that construct stochastic processes of underlying prices with short-range and long-range dependencies. We derive solutions of option Greeks and compare with those in the Black-Scholes model. We analyse performance of delta hedging strategy using simulated time series data and verify that hedging errors are biased particularly for long-range dependence cases. We also apply underlying model calibration on S&P 500 index (SPX) and the U.S./Euro rate, and implement delta hedging on SPX options.
MSC Classification: 60E05 , 60F05 , 65C10 , 65C30 , 91B70
Efficacy of mFOLFOX6 plus Bevacizumab Regimen in Advanced Colorectal Cancer after Deep Hyperthermia: A Single-center Retrospective Study
Authors: Han Guohu , Cui Lihua , Sun Changchun , Yu Lijiang , Liu Shenzha 
Published: July 2023

Abstract
The authors have requested that this preprint be removed from Research Square.
Relationship between myocardial flow reserve measured by a dynamic cadmium-zinc-telluride camera and increase rate in myocardial uptake of radionuclide during stress
Authors: Niimi Takanaga , Unno Kazumasa , Hirayama Kenshi , Yoshida Satoya , Nanasato Mamoru 
Published: July 2023

Abstract
Objective
A cadmium-zinc-telluride (CZT) camera can simultaneously evaluate the myocardial flow reserve (MFR) and perform myocardial perfusion imaging. Unlike conventional single-photon emission computed tomography (SPECT) cameras, it can detect multivessel coronary artery disease (CAD) without underestimation. However, obtaining MFR measurements using routine SPECT is difficult. To determine whether the increase rate (IR) could be an alternative in the absence of MFR measurements, we examined the relationship between the MFR measured simultaneously with a dynamic CZT camera and IR in myocardial radionuclide uptake during stress.
Methods
We retrospectively analyzed the clinical images of 52 patients who underwent dynamic SPECT for evaluation of suspected CAD (34 men and 18 women; mean age:66.1 ± 10.4 years) after injection of 99mTc-sestamibi for rest and stress imaging, respectively. Radionuclide was injected at 1 ml/s using an automatic injector and flushed with 30 ml of saline. Dynamic CZT SPECT imaging data for calculating MFR were analyzed using commercially available software. An increase in radionuclide uptake in the myocardium during stress was defined as IR, and CAD was detected using myocardial perfusion imaging. The IR was calculated as the stress image/rest image normalized by the dose.
Results
Comparing the global CAD diagnostic performance of MFR and the IR, the area under the receiver operating characteristic curve was 0.78 for MFR and 0.57 for the IR (p = 0.024, cutoff value of MFR was 2.46, and IR was 1.01). However, in the case of 3-vessel disease, 67% of the participants were below the cutoff value, even for IR, and the contribution to CAD diagnosis was higher than that for one- and 2-vessel disease.
Conclusions
The IR of myocardial uptake of radionuclides during stress may provide additional information for myocardial perfusion imaging, such as diagnosing 3-vessel disease, even when MFR measurements are impossible.
Bioanalytical Method Development and Validation of Doxorubicin and Lapatinib in Rat Plasma Using UHPLC-HESI-MSn
Authors: Shaik Khaja Moinuddin , Srika Pirangi , Sharma Parul , Nandi Sukhendu 
Published: July 2023

Abstract
A simple, selective, and robust method was developed to simultaneously detect doxorubicin and lapatinib in rat plasma using UHPLC-HESI-MSn based on a protein precipitation technique for extracting analytes from rat plasma. Chromatographic separation was accomplished on Waters symmetry® C18 3.5µm (4.6×75mm) column using 0.1% acetic acid in water and 0.1% acetic acid in acetonitrile as eluents followed by HESI-MSn detection. Quantifying doxorubicin and lapatinib using curcumin as an internal standard was carried out using a single reaction monitoring mode of the tandem mass spectrometer. The method is valid over the concentration range of 0.75 ng-1200 ng. This UHPLC-HESI-MSn method was fully validated based on other parameters like selectivity, matrix effect, recovery and stability. This validated method is straightforward, robust and can be clinically applicable.
A lightweight detection model for greenhouse-cultivated strawberries based on YOLOv5
Authors: Li Yaodi , Xue Jianxin 
Published: July 2023

Abstract
The efficient detection of strawberries has great significance in the realization of strawberry production estimation and automatic picking in the greenhouse. Factors such as the complex growing environment in the field and fruit aggregation shading, especially for immature strawberries at the turning stage and mature strawberries with high similarity in shape, size, and even color, resulted in low accuracy of detection. This research aims at establishing an improved lightweight model based on YOLOv5 which is for strawberry ripeness detection in natural environments, in response to the problems of some current detection models whose structures are complex and difficult to deploy on low-cost devices. The method first adds a smaller target detection layer to the original network, then removes part of the deep structure of the network to reduce the complexity of the model, by adjusting the depth-multiple and width-multiple partially to achieve a lighter model while ensuring accuracy. After that, the performance of the model was further improved by introducing the BiFPN structure and SimAM attention module. The experimental results show that the improved model provides an effective method for detecting strawberries in natural environments. Compared with the YOLOv5s model, the improved model has a 60.35% reduction in parameters and a 55.47% reduction in the model size, and the mAP, mAP0.5:0.95, and F1 are improved to 91.86%, 79.04%, and 90.9%, respectively. The model proposed in this research proves an excellent generalization performance in three strawberry test sets and provides a reference for subsequent deployment in small/low-cost picking robots.
A broad-scale biometrical response of a pristine meadow, Posidonia oceanica, to winter and summer conditions in the north-eastern Mediterranean coast
Authors: Mutlu Erhan , Duman Güler Sıla , Karaca Doğukan , Özvarol Yaşar , Şahin Ahmet 
Published: July 2023

Abstract

The concept of the present study was derived from a study to ground-truth the acoustical echo energy of the seagrass biometrics in order not to use any destructive method and was scoped to study the estimated environment-related biometrical distribution of a pristine marine phanerogam, Posidonia oceanica meadow, along the entire Turkish Mediterranean coast. This study also provided the first knowledge on the broad-scale extent of the meadow from a significant coast length in the Mediterranean Sea. For this purpose, two surveys were conducted covering bottom depths of 5–35 m in the critical seasons (winter and summer 2019) of a subtropical coast for the growth dynamics of the meadow. The meadow samples were collected in a frame of 0.4 x 0.4 m by SCUBA divers, which was a destructive method. The physicochemical and optical environments of the water were evaluated with the biometrical dynamics of the meadow. Orderly, season, region, bottom types, and bottom depths dictated the biometrical distribution. The meadow shoot density showed the environment to be in good ecological condition without changing the average shoot density in season. Other biometrics grew 2-fold higher in summer compared to winter (water temperature and salinity). The region influenced by the Aegean Sea had lower biometrical values than the other two regions. Hard (rock and matte) and soft (sand and mud) benthic environments differentiated the biometrics as follows: Contrary to the morphometric variables, the density biometrics decreased linearly from the hard bottom to the soft bottom. The density dynamics were partially contrasted with the morphometrical dynamics. Rhizome-related biometrics were independently governed by the leaf-related biometrics, especially by nitrogen-based nutrients in near-bottom water. The optical parameter, especially PAR, a certain percent of the daylight was effective during the growth of the biometrics. The present study provided the first knowledge on a broad-scale biometrical distribution from the entire Turkish Mediterranean coast to the seagrass studies.
Elovanoids are neural resiliency epigenomic regulators targeting histone modifications, DNA methylation, tau phosphorylation, telomere integrity, senescence programming, and dendrite integrity
Authors: Bazan Nicolas , Bhattacharjee Surjyadipta , Kala-Bhattacharjee Sayantani , Ledet Alexander , Mukherjee Pranab 
Published: July 2023

Abstract
Cellular identity, developmental reorganization, genomic structure modulation, and susceptibility to diseases are determined by epigenomic regulation by multiple signaling interplay. Here we demonstrate that elovanoids (ELVs), mediators derived from very-long-chain polyunsaturated fatty acids (VLC-PUFAs, n-3, C > 28), and their precursors in neurons in culture overcome the damage triggered by oligomeric amyloid-beta (OAβ), erastin (ferroptosis-dependent cell death), or other insults that target epigenomic signaling. We uncover that ELVs counteract damage targeting histones H3K9 and H3K27 methylation and acetylation; tau hyperphosphorylation (pThr181, pThr217, pThr231, and pSer202/pThr205 (AT8)); senescence gene programming (p16INK4a, p27KIP, p21CIP1, and p53); DNA methylation (DNAm) modifying enzymes: TET (DNA hydroxymethylase), DNA methyltransferase, DNA demethylase, and DNAm (5mC) phenotype. Moreover, ELVs revert OAβ-triggered telomere length (TL) attrition as well as upregulation of telomerase reverse transcriptase (TERT) expression fostering dendrite protection and neuronal survival. Thus, ELVs modulate epigenomic resiliency by pleiotropic interrelated signaling.
Grp94 Inhibitor HCP1 Suppressed the Replication of SVA in BHK-21 Cells and
PK-15 Cells
Authors: Wang Shuo , Cui XiaoLing , Hui Ren , Yao Wen , Zhao BaoXiang , Li Jun , Miao JunYing 
Published: July 2023

Background:
Glucoregulatory protein 94 (Grp94) is necessary in the post-viral life cycle and play a quality control role in viral proteins, but the role of Grp94 in regulating viral replication in host cells is not well known. Therefore, finding a compound that can regulate Grp94 will help us to study the mechanism of viral replication. Previously, we synthesized a coumarin pyrazoline derivative HCP1 that is an effective inhibitor of Grp94. We suppose that HCP1 may inhibit viral replication.

Objective:
This study aimed to investigate the effect of HCP1 on the replication ability of Senecavirus A (SVA), so as to provide a target and a leading compound for revealing the pathogenic mechanism of the virus and developing antiviral drugs.

Methods:
Rat cell lines BHK-21 and porcine cell lines PK-15 were infected with SVA, and the infected cells were treated with different concentrations of HCP1. The cell viability (CCK-8), virus titer (TCID50), autophagy level and Grp94 expression were measured.

Results:
The results showed that low concentration of HCP1 decreased viral titer and viral load in BHK-21 and PK-15 cells, and 5μM HCP1 significantly decreased the expression of SVA VP2 protein. In addition, SVA infection can lead to an increased level of autophagy, and HCP1 can inhibit host cell autophagy caused by SVA infection, thereby inhibiting viral replication and infection. Conclusion: These findings reveal that Grp94 is a key factor of controlling SVA replication, and its inhibitor HCP1 suppress SVA replication through inhibiting the increase of Grp94 protein level and autophagy induced by SVA. This study will contribute to the development of a new class of small molecule antiviral drugs.
Comparative analysis of unilateral and bilateral flexible ureterorenoscopy: a cohort multicentre study
Authors: Gadzhiev N. K. , Petrov A. D. , Gorgotsky I. A. , Labetov I. A. , Malkhasyan V. A. , Vorobyov V. A. , Shkarupa D. D. 
Published: July 2023

Introduction. Flexible ureteroscopy (fURS) with laser lithotripsy is the «gold standard» for minimally invasive treatment in patients with kidney stones less than 20 mm. Currently, there are no objective data on the efficacy and safety of bilateral interventions.Objective. To study the results of bilateral flexible URS (B-fURS) versus unilateral flexible URS (U-fURS).Materials & methods. Eighty patients prospectively enrolled in the study from July 2022 to December 2022 and was divided into 2 groups. Group 1 (n = 40) underwent U-fURS and Group 2 (n = 40) underwent B-fURS. A single stone up to 20 mm or multiple small calyx stones was an indication for the operation. The baseline values were comparable between the groups, but in the B-fURS group a 39.0% higher incidence (p > 0.002) of multiple stones and a 28.0% higher incidence (p > 0.001) of stones in the lower pole. Previous interventions were also more frequent in Group 1 (B-fURS) patients.Results. Stone-free rate did not differ (p > 0.9) between the groups and was 95.0% and 97.5%, respectively. No serious complications (p > 0.9) of Clavien III–V were observed in both groups.Conclusion. Bilateral flexible ureteroscopy is a safe and effective option for patients with bilateral kidney stones, allowing removal of stones in one anesthesia on both sides.
Firm-Level Pay Disparity and Breach Risk
Authors: He Chris Zhijian , Li Tianpei , Pinsker Robert 
Published: July 2023

ABSTRACT
The 2008 financial crisis highlighted the significant, vertical pay disparity between chief executive officers (CEOs) and all other employees. Following equity theory, prior research finds negative associations between vertical pay disparity and job satisfaction and performance (i.e., more errors). We build on this research to investigate if vertical pay disparity between the CEO and employees/other executives is a previously unidentified determinant of data security breaches (DSBs). Results suggest that firms with large, vertical pay disparities are more likely to be breached, are associated with more DSBs, and are more likely to be associated with internal DSBs. We also find some evidence of remediation through narrowing the pay disparity between CEOs and employees/other executives after the DSB. Our findings contribute to the growing accounting information systems (AIS) cybersecurity literature, extend equity theory to a new context, and should be of interest to AIS governance researchers and stakeholders.
Assessment of Meal Anticipation for Improving Fully Automated Insulin Delivery in Adults With Type 1 Diabetes
Authors: Garcia-Tirado Jose , Colmegna Patricio , Villard Orianne , Diaz Jenny L. , Esquivel-Zuniga Rebeca , Koravi Chaitanya L. K. , Barnett Charlotte L. , Oliveri Mary C. , Fuller Morgan , Brown Sue A. , DeBoer Mark D. , Breton Marc D. 
Published: July 2023

OBJECTIVE
Meals are a consistent challenge to glycemic control in type 1 diabetes (T1D). Our objective was to assess the glycemic impact of meal anticipation within a fully automated insulin delivery (AID) system among adults with T1D.

RESEARCH DESIGN AND METHODS
We report the results of a randomized crossover clinical trial comparing three modalities of AID systems: hybrid closed loop (HCL), full closed loop (FCL), and full closed loop with meal anticipation (FCL+). Modalities were tested during three supervised 24-h admissions, where breakfast, lunch, and dinner were consumed per participant’s home schedule, at a fixed time, and with a 1.5-h delay, respectively. Primary outcome was the percent time in range 70–180 mg/dL (TIR) during the breakfast postprandial period for FCL+ versus FCL.

RESULTS
Thirty-five adults with T1D (age 44.5 ± 15.4 years; HbA1c 6.7 ± 0.9%; n = 23 women and n = 12 men) were randomly assigned. TIR for the 5-h period after breakfast was 75 ± 23%, 58 ± 21%, and 63 ± 19% for HCL, FCL, and FCL+, respectively, with no significant difference between FCL+ and FCL. For the 2 h before dinner, time below range (TBR) was similar for FCL and FCL+. For the 5-h period after dinner, TIR was similar for FCL+ and FCL (71 ± 34% vs. 72 ± 29%; P = 1.0), whereas TBR was reduced in FCL+ (median 0% [0–0%] vs. 0% [0–0.8%]; P = 0.03). Overall, 24-h control for HCL, FCL, and FCL+ was 86 ± 10%, 77 ± 11%, and 77 ± 12%, respectively.

CONCLUSIONS
Although postprandial control remained optimal with hybrid AID, both fully AID solutions offered overall TIR &gt;70% with similar or lower exposure to hypoglycemia. Anticipation did not significantly improve postprandial control in AID systems but also did not increase hypoglycemic risk when meals were delayed.
THE CONCEPT OF THE SMART CITY AS AN ALTERNATIVE APPROACH TO RESTORE THE URBAN INFRASTRUCTURE OF UKRAINE DURING THE POST-WAR PERIOD
Authors: Zakharova Oksana , Kozyriev Dmytro 
Published: July 2023

Modern information technologies in the world are developing at a very fast pace and gradually cover all spheres of human life. This greatly facilitates and improves a person's life, fills it with new meaning. This is how smart cities are built in developed countries. These are approaches to the management of urban infrastructure, where innovations and breakthrough information technologies allow citizens not only to use resources economically, but also to actively participate in the life and development of their own city. This allows to form a strategy for a successful and competitive future of the city. To date, the concept of a smart city for Ukraine is not the most relevant due to the fact that the country is in the active phase of the war. However, in order to speed up the country's recovery processes in the post-war period, one should reasonably approach the choice of the development strategy that will become the basis for restoring the Ukrainian economy in the near future. A deeper study of the essence of the concept of a smart city has led to the conclusion that this approach can be saving for the weakened economy of Ukraine and create conditions for its future rapid development.
The paper considers the content of the concept of a smart city and its evolution over time. It has been established that the main components of the successful implementation of the concept of a smart city are the economy, mobility, environment, human capital, life potential and management. The essence of each of the six selected components is detailed. Based on a study of the goals, content and best practices for implementing the concept of a smart city within such developed cities of the world as New York, Amsterdam, Barcelona and Shanghai, the features of the functioning of successful smart cities in the world are determined. The most successful smart city projects are given, which can become guidelines for the restoration of Ukrainian cities. Taking into account the current global trends in the construction of smart cities and taking into account the Ukrainian geopolitical specifics, the key directions for the restoration of Ukrainian cities in the post-war period are formulated. These areas include security, infrastructure, mobility, healthy life, information and ecology.
THE PROBLEM OF CIVILIZATIONAL CHOICE: THE MULTIFACTOR FUNCTION OF EXPORT
Authors: Zagoruiko І. О. , Petkova L. O. 
Published: July 2023

The article is devoted to the methodology of modeling the influence of technical-economic, socio-economic and socio-political factors on the export of goods and services in the conditions of civilizational choice. These factors are considered on the example of foreign trade of Ukraine for the period from the time of restoration of its independence to the beginning of the full-scale Russian invasion. In the case of Ukraine, such factors include: age and technological structures of the main production assets; the structure of foreign ownership; monopolization of the labor market; electoral sympathies and age structure of the population; the magnitude of migration, unemployment and crime. Given the long period of colonial dependence of Ukraine, the factor of inertia of foreign economic relations is also taken into account. All these factors to one degree or another influenced the choice of foreign trade partners by Ukrainian firms.
These factors are taken into account in the independent variables of the proposed export function. The function has a logarithmic-difference form: in its equation, all variables are dimensionless quantities - logarithms of the ratios of the differences of certain aggregate quantities and the corresponding factors. This form of the proposed function makes it linear and invariant with respect to the replacement of all relations with their inverses, as well as defined even for zero values of the factors.
The export function is normalized: each relation that characterizes the firm is divided into a similar relation that characterizes the industry in which it operates. Variables reflecting social factors are differentiated by regions in which a certain firm operates.
In a modified form, the proposed export function can serve as a tool for analyzing the evolution of foreign trade of other countries - both those that have existed for a long time and those that have only recently gained (or will gain) political independence.
The logarithmic-difference form of the proposed export function can be used as a certain mathematical "template" for constructing other econometric functions that reflect the choice of economic entities between two opposite directions of their activity.