bluuebunny/crossref_metadata_2025_split huggingface dataset:
Distilled beverage aging: A review on aroma characteristics, maturation mechanisms, and artificial aging techniques
Authors: Wang Lulu , Chen Shuang , Xu Yan 
Published: December 2022

AbstractThe market value of distilled beverage relies on its quality with a major contribution of distinctive and fascinating aromas. The aroma of distilled beverage is built on the basis of chemical components and can be modified through a series of physical and chemical processes such as aging. Revealing the hidden knowledge behind the evolution of numerous chemical components during these physicochemical processes in distilled beverages is not only significant but also challenging due to its complex system. In this review, the trends in the changes of associated aroma compounds over aging are proposed on the basis of understanding the relationship between chemical components and aroma profiles of numerous typical distilled beverages. The different aging systems, both classical platforms from Eastern countries (pottery jars) to Western countries (wood barrels), and modern platforms such as artificial aging technologies are outlined and compared with their respective applications. Optimizing aging processes is a challenging but imperative step, which warrants further fundamental knowledge from targeting aging‐related molecules to the exploration of multitude physicochemical reaction mechanisms that occur during this process, such as the formation of potent odorant compounds in specific containers and environments, as well as mass transfer processes between solid and liquid interfaces. Understanding these maturation mechanisms of distilled beverages expressed by chemosensory signature holds promise for major improvements in future aging technologies that can efficiently yield stable and high‐quality products.
Potential implications of oxidative modification on dietary protein nutritional value: A review
Authors: Li Fang , Wu Xiaojuan , Liang Ying , Wu Wei 
Published: December 2022

AbstractDuring food processing and storage, proteins are sensitive to oxidative modification, changing the structural characteristics and functional properties. Recently, the impact of dietary protein oxidation on body health has drawn increasing attention. However, few reviews summarized and highlighted the impact of oxidative modification on the nutritional value of dietary proteins and related mechanisms. Therefore, this review seeks to give an updated discussion of the effects of oxidative modification on the structural characteristics and nutritional value of dietary proteins, and elucidate the interaction with gut microbiota, intestinal tissues, and organs. Additionally, the specific mechanisms related to pathological conditions are also characterized. Dietary protein oxidation during food processing and storage change protein structure, which further influences the in vitro digestion properties of proteins. In vivo research demonstrates that oxidized dietary proteins threaten body health via complicated pathways and affect the intestinal microenvironment via gut microbiota, metabolites, and intestinal morphology. This review highlights the influence of oxidative modification on the nutritional value of dietary proteins based on organs and the intestinal tract, and illustrates the necessity of appropriate experimental design for comprehensively exploring the health consequences of oxidized dietary proteins.
Screening new breeding japonica rice varieties by rice quality, three processing characteristics, and odor characteristics
Authors: Asimi Sailimuhan , Xin Ren , Min Zhang , Sixuan Li , Lv Qixin , Lingqi Meng 
Published: December 2022

AbstractRice's yield, cooking, and sensory quality are primary considerations in selecting new breeding rice varieties, which are determined by the rice eating quality such as processing and flavor characteristics. Thus, in this study, to advance the breed of new superior japonica rice varieties, the differences in the rice quality, processing characteristics, and flavor characteristics between 12 newly‐bred varieties (H2‐36, H2‐42, H2‐53, H2‐59, H2‐63, H2‐73, H2‐74, H2‐79, H2‐81, H2‐82, H2‐89, and H2‐91) and 1 commercial variety (Kenyu38) were analyzed. The results indicated that H2‐42 has a reasonable length‐to‐width ratio (1.51), high rice yield, good color, reasonable amylose, protein content, excellent water existence index, accessible storage, and the highest taste value. Electronic nose results showed significant differences in aldehydes, ketones, and alcohols among 13 rice varieties. Aroma analysis results showed that H2‐42 had the highest n‐hexanal (14.63 µg/kg), (E,E)‐2,4‐nonadienal (37.24 µg/kg), nonanal (19.93 µg/kg), and decanal (4.81 µg/kg); those were important aroma components in cooked rice. The Pearson correlation analysis showed that hardness, springiness, cohesiveness, trough viscosity, peak time, and pasting temperature were the crucial factors that affected rice quality. According to partial least squares regression analysis, total color change, final viscosity, setback, (E)‐2‐heptenal, and 2‐methyl‐undecanol were the most important factors that distinguished the rice quality. In conclusion, H2‐42 rice was better apparent quality, processing characteristics, and aroma compounds. Therefore, H2‐42 has the potential for identification and promotion.Practical ApplicationThe results from this study will provide data support for the cultivation, application, and quality improvement of high‐quality rice varieties. In addition, it gives new ideas and methods for studying rice eating quality.
Serum interleukin‐18 level as a possible early diagnostic marker of systemic juvenile idiopathic arthritis
Authors: Souma Kento , Fujimura Junya , Nishiyama Atushi , Oyazato Yoshinobu , Kaneko Shuya , Shimizu Masaki , Morisawa Takeshi 
Published: December 2022

AbstractEarly diagnosis of systemic juvenile idiopathic arthritis (s‐JIA) is a prerequisite for therapeutic efficacy. However, it is often challenging because most patients with s‐JIA do not show arthritis at disease onset and are simply diagnosed with fever of unknown origin. Serum ferritin levels have commonly been used to diagnose s‐JIA because they increase in patients with this condition by more than 5 times their normal value. However, there are no definite biomarkers for s‐JIA, which makes the clinical diagnosis of s‐JIA difficult. We report a case of s‐JIA in which interleukin (IL)‐18 elevation was observed before ferritin elevation at the early phase of s‐JIA. We propose serum IL‐18 levels as a more useful biomarker for the early diagnosis of s‐JIA compared to serum ferritin levels.
Rural and socioeconomic differences in the effectiveness of the HEART Pathway accelerated diagnostic protocol
Authors: O'Neill James C. , Ashburn Nicklaus P. , Paradee Brennan E. , Snavely Anna C. , Stopyra Jason P. , Noe Greg , Mahler Simon A. 
Published: December 2022

AbstractBackgroundThe HEART Pathway is a validated accelerated diagnostic protocol (ADP) for patients with possible acute coronary syndrome (ACS). This study aimed to compare the safety and effectiveness of the HEART Pathway based on patient rurality (rural vs. urban) or socioeconomic status (SES).MethodsWe performed a preplanned subgroup analysis of the HEART Pathway Implementation Study. The primary outcomes were death or myocardial infarction (MI) and hospitalization at 30 days. Proportions were compared by SES and rurality with Fisher's exact tests. Logistic regression evaluated for interactions of ADP implementation with SES or rurality and changes in outcomes within subgroups.ResultsAmong 7245 patients with rurality and SES data, 39.9% (2887/7245) were rural and 22.2% were low SES (1607/7245). The HEART Pathway identified patients as low risk in 32.2% (818/2540) of urban versus 28.1% (425/1512) of rural patients (p = 0.007) and 34.0% (311/915) of low SES versus 29.7% (932/3137) high SES patients (p = 0.02). Among low‐risk patients, 30‐day death or MI occurred in 0.6% (5/818) of urban versus 0.2% (1/425) rural (p = 0.67) and 0.6% (2/311) with low SES versus 0.4% (4/932) high SES (p = 0.64). Following implementation, 30‐day hospitalization was reduced by 7.7% in urban patients (adjusted odds ratio [aOR] 0.76, 95% confidence interval [CI] 0.66–0.87), 10.6% in low SES patients (aOR 0.68, 95% CI 0.54–0.86), and 4.5% in high SES patients (aOR 0.83, 95% CI 0.73–0.94). However, rural patients had a nonsignificant 3.3% reduction in hospitalizations.ConclusionsHEART Pathway implementation decreased 30‐day hospitalizations regardless of SES and for urban patients but not rural patients. The 30‐day death or MI rate was similar among low‐risk patients.
COVID‐19 pandemic‐related changes in utilization of telehealth and treatment overall for alcohol use problems
Authors: Palzes Vanessa A. , Chi Felicia W. , Metz Verena E. , Campbell Cynthia , Corriveau Caroline , Sterling Stacy 
Published: December 2022

AbstractBackgroundDuring the COVID‐19 pandemic, specialty alcohol treatment transitioned rapidly to telehealth, which may have created barriers for some patients but increased access for others. This study evaluated the impact of the COVID‐19 pandemic on alcohol treatment utilization and potential disparities.MethodsWe analyzed electronic health record and claims data from Kaiser Permanente Northern California for adults with alcohol use problems (alcohol use disorder or unhealthy alcohol use diagnoses) during pre‐COVID‐19 (March to December 2019, n = 32,806) and COVID‐19 onset (March to December 2020, n = 26,763). Generalized estimating equation models were fit to examine pre‐COVID‐19 to COVID‐19 onset changes in alcohol treatment initiation, engagement, and retention (days in treatment). Heterogeneity in pre‐COVID‐19 to COVID‐19 onset changes in treatment utilization by age, race, and ethnicity; neighborhood deprivation index (NDI); and comorbid medical and psychiatric disorders were also examined.ResultsTreatment initiation increased during the COVID‐19 onset period (adjusted odds ratio [aOR] = 1.46; 95% CI = 1.41–1.52). The increases in odds of treatment initiation during the COVID‐19 onset period compared with the pre‐COVID period were largest among patients aged 18–34 years (aOR = 1.59; 95% CI = 1.48–1.71), those without medical conditions (aOR = 1.56; 95% CI = 1.49–1.65), and those without psychiatric disorders (aOR = 1.60; 95% CI = 1.51–1.69). Patients aged 18–34 years (aOR = 5.21; 95% CI = 4.67–5.81), those with the second highest NDIs (aOR = 4.63; 95% CI = 4.12–5.19), and those without medical (aOR = 4.34; 95% CI = 4.06–4.65) or psychiatric comorbidities (aOR = 4.48; 95% CI = 4.11–4.89) had the greatest increases in telehealth treatment initiation from pre‐COVID‐19 to COVID‐19 onset. Treatment engagement and retention also increased during COVID‐19 onset, with the greatest increase among patients aged 35–49 years who initiated treatment via telehealth (engagement: aOR = 2.33; 95% CI = 1.91–2.83; retention: adjusted mean difference [aMD] = 3.3 days; 95% CI = 2.6–4.1). We found no significant variation of changes in treatment utilization by race and ethnicity.ConclusionsThe transition to telehealth in this healthcare system may have attracted subgroups of individuals who have historically underutilized care for alcohol use problems, particularly younger and healthier adults, without exacerbating pre‐pandemic racial and ethnic disparities in treatment utilization.
Effect of discharge opioid on persistent postoperative opioid use: a retrospective cohort study comparing tapentadol with oxycodone
Authors: Lam T. , Xia T. , Biggs N. , Treloar M. , Cheng O. , Kabu K. , Stevens J. A. , Evans J. D. , da Gama M. E. , Lubman D. I. , Nielsen S. 
Published: December 2022

SummaryOpioid harm can vary by opioid type. This observational study examined the effect of opioid type (oxycodone vs. tapentadol) on rates of persistent postoperative opioid use (‘persistence’). We linked hospital and community pharmacy data for surgical patients who were dispensed discharge opioids between 1 January 2016 and 30 September 2021. Patients were grouped by opioid experience (‘opioid‐naive’ having received no opioids in the 3 months before discharge) and formulation of discharge opioid (immediate release only or modified release ± immediate release). Mixed‐effects logistic regression models predicted persistence (continued use of any opioid at 90 days after discharge), controlling for key persistence risk factors. Of the 122,836 patients, 2.31% opioid‐naive and 27.24% opioid‐experienced patients met the criteria for persistence. For opioid‐naive patients receiving immediate release opioids, there was no significant effect of opioid type. Tapentadol modified release was associated with significantly lower odds of persistence compared with oxycodone modified release, OR (95%CI) 0.81 (0.69–0.94) for opioid‐naive patients and 0.81 (0.71–0.93) for opioid‐experienced patients. Among patients who underwent orthopaedic surgery (n = 19,832), regardless of opioid experience or opioid formulation, the odds of persistence were significantly lower for those who received tapentadol compared with oxycodone. This was one of the largest and most extensive studies of persistent postoperative opioid use, and the first that specifically examined persistence with tapentadol. There appeared to be lower odds of persistence for tapentadol compared with oxycodone among key subgroups, including patients prescribed modified release opioids and those undergoing orthopaedic surgery.
A drug–drug interaction study with letermovir and acyclovir in healthy participants
Authors: Menzel Karsten , McCrea Jacqueline B. , Fancourt Craig , Witter Rose , Zhao Tian , Stoch S. Aubrey , Iwamoto Marian 
Published: December 2022

Letermovir inhibits renal tubular organic anion transporter 3 (OAT3) in vitro and is predicted to inhibit OAT3 in vivo. Acyclovir, a substrate for OAT3, is likely to be coadministered with letermovir; therefore, letermovir may increase acyclovir concentrations. A drug–drug interaction study was conducted in healthy participants (N = 16) to assess the effect of letermovir on acyclovir pharmacokinetics. On Day 1, participants received a single oral dose of 400 mg acyclovir; on Days 2–7, participants received oral doses of 480 mg letermovir once daily with a single oral dose of 400 mg acyclovir coadministered on Day 7. Coadministration with letermovir resulted in geometric mean ratios (90% confidence intervals) for acyclovir area under the concentration–time curve from administration to infinity and maximum plasma concentration of 1.02 (0.87–1.20) and 0.82 (0.71–0.93), respectively. No notable safety issues were reported. No clinically significant interaction was observed between letermovir and acyclovir in healthy participants and no dose adjustment is required for coadministration.
The risk of fragility fractures following initiation of gabapentin and pregabalin—A Danish, nationwide, high‐dimensional propensity score‐matched cohort study
Authors: Jørgensen Emilie Berg , Overgaard Lærke Karner , Folkestad Lars , Damkier Per , Hallas Jesper , Henriksen Daniel Pilsgaard 
Published: December 2022

AbstractGabapentin and pregabalin have been associated with an increased risk of fragility fractures. Due to differences in pharmacokinetics, we aimed to assess the fracture‐risk difference between the two medicines. We performed a Danish nationwide new user, high‐dimensional propensity score‐matched cohort study to assess the 90‐day risk of fragility fractures among adults, from January 1996 to December 2018. We applied a high‐dimensional propensity score to match new users of gabapentin with new users of pregabalin in a 1:1 intention‐to‐treat approach. Hazard ratios (HRs), incidence rates (IRs) and incidence rate difference (IRD) were obtained.We identified 388 236 eligible patients of which 294 223 and 98 869 initiated gabapentin and pregabalin, respectively. We included 48 272 matched pairs for further analysis. The mean age was 56 (IQR 44–69) years, and the average follow‐up was approximately 11 500 person‐years (PY). The IRs of fragility fractures were 23.7 (95%CI 21.0–26.7) and 23.2 (95%CI 20.5–26.2) per 1000 PY for gabapentin and pregabalin‐exposed patients, respectively. This yielded an HR of 1.02 (95%CI 0.86–1.21) when using gabapentin as the intervention drug and pregabalin as the reference drug. The IRD was estimated to 0.5 PY (95%CI −3.5–4.5).In conclusion, short‐term risk of fragility fractures among gabapentin initiators was not different compared to those initiating pregabalin.
Why do I teach? Teachers' instrumental and prosocial motivation predict teaching quality across East and West
Authors: Nalipay Ma. Jenina N. , King Ronnel B. , Yeung Susanna S. S. , Chai Ching Sing , Jong Morris Siu‐Yung 
Published: December 2022

AbstractBackgroundIndividuals pursue teaching careers for numerous reasons, such as for instrumental or prosocial purposes.AimsThis study examined the personal (instrumental motivation) and social (prosocial motivation) utility of teaching as predictors of teaching quality in terms of clarity of instruction, classroom management, and cognitive activation.SampleWe used data from the Teaching and Learning International Survey (TALIS) 2018, which included 50,595 teachers from 1252 schools in 10 countries and regions.MethodsWe performed a series of regression analyses to test a model of instrumental and prosocial motivation to predict three indicators of teaching quality (clarity of instruction, classroom management, and cognitive activation) while controlling for demographic characteristics (age, sex, educational level, and teaching experience). We examined this model in countries and regions from Eastern (Japan, Korea, Singapore, Shanghai and Taipei) and Western (Australia, Canada, New Zealand, United Kingdom and the United States of America) cultures.ResultsResults demonstrated that instrumental motivation predicted clarity of instruction in the East and classroom management in both the East and West; prosocial motivation, however, was a more consistent predictor of all indicators of teaching quality, except classroom management in the West, across cultures.ConclusionTeachers' prosocial motivation to benefit others and contribute to society must be considered to understand teaching quality across various cultural contexts. Implications for theory, practice and policy are discussed.
Neuraminidase is a host‐directed approach to regulate neutrophil responses in sepsis and COVID‐19
Authors: de Oliveira Formiga Rodrigo , Amaral Flávia C. , Souza Camila F. , Mendes Daniel A. G. B. , Wanderley Carlos W. S. , Lorenzini Cristina B. , Santos Adara A. , Antônia Juliana , Faria Lucas F. , Natale Caio C. , Paula Nicholas M. , Silva Priscila C. S. , Fonseca Fernanda R. , Aires Luan , Heck Nicoli , Starick Márick R. , Queiroz‐Junior Celso M. , Santos Felipe R. S. , de Souza Filipe R. O. , Costa Vivian V. , Barroso Shana P. C. , Morrot Alexandre , Van Weyenbergh Johan , Sordi Regina , Alisson‐Silva Frederico , Cunha Fernando Q. , Rocha Edroaldo L. , Chollet‐Martin Sylvie , Hurtado‐Nedelec Maria Margarita , Martin Clémence , Burgel Pierre‐Régis , Mansur Daniel S. , Maurici Rosemeri , Macauley Matthew S. , Báfica André , Witko‐Sarsat Véronique , Spiller Fernando 
Published: December 2022

AbstractBackground and PurposeNeutrophil overstimulation plays a crucial role in tissue damage during severe infections. Because pathogen‐derived neuraminidase (NEU) stimulates neutrophils, we investigated whether host NEU can be targeted to regulate the neutrophil dysregulation observed in severe infections.Experimental ApproachThe effects of NEU inhibitors on lipopolysaccharide (LPS)‐stimulated neutrophils from healthy donors or COVID‐19 patients were determined by evaluating the shedding of surface sialic acids, cell activation, and reactive oxygen species (ROS) production. Re‐analysis of single‐cell RNA sequencing of respiratory tract samples from COVID‐19 patients also was carried out. The effects of oseltamivir on sepsis and betacoronavirus‐induced acute lung injury were evaluated in murine models.Key ResultsOseltamivir and zanamivir constrained host NEU activity, surface sialic acid release, cell activation, and ROS production by LPS‐activated human neutrophils. Mechanistically, LPS increased the interaction of NEU1 with matrix metalloproteinase 9 (MMP‐9). Inhibition of MMP‐9 prevented LPS‐induced NEU activity and neutrophil response. In vivo, treatment with oseltamivir fine‐tuned neutrophil migration and improved infection control as well as host survival in peritonitis and pneumonia sepsis. NEU1 also is highly expressed in neutrophils from COVID‐19 patients, and treatment of whole‐blood samples from these patients with either oseltamivir or zanamivir reduced neutrophil overactivation. Oseltamivir treatment of intranasally infected mice with the mouse hepatitis coronavirus 3 (MHV‐3) decreased lung neutrophil infiltration, viral load, and tissue damage.Conclusion and ImplicationsThese findings suggest that interplay of NEU1–MMP‐9 induces neutrophil overactivation. In vivo, NEU may serve as a host‐directed target to dampen neutrophil dysfunction during severe infections.
The complexity‐aesthetics relationship for musical rhythm is more fixed than flexible: Evidence from children and expert dancers
Authors: Cameron Daniel J. , Caldarone Nicole , Psaris Maya , Carrillo Chantal , Trainor Laurel J. 
Published: December 2022

AbstractThe urge to move to music (groove) depends in part on rhythmic syncopation in the music. For adults, the syncopation‐groove relationship has an inverted‐U shape: listeners want to move most to rhythms that have some, but not too much, syncopation. However, we do not know whether the syncopation‐groove relationship is relatively sensitive to, or resistant to, a listener's experience. In two sets of experiments, we tested whether the syncopation‐groove relationship is affected by dance experience or changes through development in childhood. Dancers and nondancers rated groove for 50 rhythmic patterns varying in syncopation. Dancers’ and nondancers’ ratings did not differ (and Bayesian tests provided substantial evidence that they were equivalent) in terms of mean groove and the optimal level of syncopation. Similarly, ballet and hip‐hop dancers’ syncopation‐groove relationships did not differ. However, dancers had more robust syncopation‐groove relationships (higher goodness‐of‐fit) than nondancers. Children (3–6 years old) completed two tasks to assess their syncopation‐groove relationships: In a 2‐alternative‐forced choice task, children compared rhythms from 2 of 3 possible levels of syncopation (low, medium, and high) and chose which rhythm in a pair was better for dancing. In a dance task, children danced to the same rhythms. Results from both tasks indicated that for children, as for adults, medium syncopation rhythms elicit more groove than low syncopation rhythms. A follow‐up experiment replicated the 2‐alternative‐forced choice task results. Taken together, the results suggest the optimal level of syncopation for groove is resistant to experience, although experience may affect the robustness of the inverted‐U relationship.Research HighlightsIn Experiment 1, dancers and nondancers rated groove (the urge to move) for musical rhythms, demonstrating the same inverted‐U relationships between syncopation and groove.In Experiment 2, children and adults both chose rhythms with moderate syncopation more than low syncopation as more groove‐inducing or better for dancing.Children also danced more for moderate than low syncopation, showing a close perception‐behavior relationship across tasks.Similarities in the syncopation‐groove relationship regardless of dance training and age suggest that this perceptual and behavioral groove response to rhythmic complexity may be quite resistant to experience.