bluuebunny/crossref_metadata_2025_split huggingface dataset:
Abstract 755: The impact of cancer treatment on cognitive function and quality of life in patients undergoing treatment at a tertiary care hospital in New Delhi, India
Authors: Francis Delfin Lovelina 
Published: April 2023

Abstract
Background: Cognitive dysfunction is becoming a more well-known complication of cancer and its treatment. Cancer-related cognitive changes and impairment have also been documented in non-central nervous system (non-CNS) cancer patients. The majority of research in this area has discovered that a subset of patients appear to be vulnerable to this complication even after treatment has ended, and they frequently struggle with multitasking, short-term memory, word-finding, attention, or concentration. It is critical to investigate the possible link between cancer and cognitive impairment because it can have a serious impact on quality of life.
Methods: This cross-sectional study between May 2022 and October 2022, included patients who were referred to the dental outpatient department as part of a preventive/prophylactic evaluation at the tertiary care centre in New Delhi, India. After receiving informed consent, the oral health impact profile-14 instrument to assess participants' oral health-related quality of life (OHRQoL) and the Montreal Cognitive Assessment (MOCA) for cognitive evaluation were used.
Results: Out of 283 patients 77% males and 23% females and vast majority had Stage III cancer. All patients' OHRQoL was hampered, but it was higher in those who developed visible oral changes during treatment versus those who did not (P =.001). Taking painkillers, losing sexual interest, difficulty in social contact, loss of taste and smell senses were the main factors affecting oral health related QoL (OHRQoL). A significant relationship was discovered between pain, speech, social eating, dry mouth, sticky saliva, and weight loss in relation to various treatment modalities. Those who were treated surgically alone had better QoL than others, according to the OHRQoL scores. In terms of delayed recall, 55% were found to be cognitively impaired, which was associated with lower OHRQoL.
Conclusion: Cognitive impairment is common in cancer patients, which may be caused by the cancer itself. It is also linked to OHRQoL and psychosocial variables. There has been little research into the relationships between cognitive function and quality of life (OHRQoL) in cancer patients. Together with previous research indicating that cognitive function and OHRQoL can influence treatment adherence and outcomes, the findings support the inclusion of cognitive screening and OHRQoL assessment as part of patient pretreatment assessment.
Citation Format: Delfin Lovelina Francis. The impact of cancer treatment on cognitive function and quality of life in patients undergoing treatment at a tertiary care hospital in New Delhi, India [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 755.
Abstract 767: Genomics and transcriptomics profiling of BRCA mutation carriers revealed the landscape of early pathogenesis of BRCA1/2-associated breast cancer
Authors: Ren Zuen , Lin Po-Han , Koh Siang Boon , Stewart Kai , Haradhvala Nick , Dedeoglu Aylin S , Smidt Ilze , Suzuki Akiko , Li David , Thant Win , Mueller Sarah , Joseph Taisha , Bossuyt Veerle , Lawrence Michael , Getz Gad , Ellisen Leif W. 
Published: April 2023

Abstract
Women who harbor germline heterozygous mutations of BRCA1 or BRCA2 have a high risk of breast cancer. Our previous study showed that patient-derived, ostensibly normal BRCA2mut/+ luminal progenitor (LP) cells are more prone to exhibit sub-chromosomal copy number variations and associated DNA damage relative to non-carriers potentially reflecting early breast tumorigenesis. The clinically assessable biomarkers for early pathological changes of BRCA1/2 mutation in LP cells remain unknown. Single-cell RNA sequencing (scRNAseq) of LP cells of BRCA1/2 mutation carriers revealed enrichment of KIT expression (KIT+) and subsequent transcriptional factor activations were observed in LP cells of BRCA1/2 mutation carriers relative to non-carriers. Moreover, overrepresented pathway analysis uncovered that KIT+ BRCA-mutated LP cells were enriched in pathways involving DNA binding transcription activator activity and oxidative phosphorylation. These gene signature profiles were recapitulated in bulk RNA-seq of BRCA2 mutation carrier LP cells. Collectively, our preliminary data suggest such analyses may identify potential biomarkers of the risk prediction for early pathogenesis of BRCA1/2 mutation carriers. Following validation of our findings via tissue microassay analysis and clinical trials, we hope to eventually assist clinicians in their decision making of prophylactic surgeries for BRCA1/2 mutation carriers.
Citation Format: Zuen Ren, Po-Han Lin, Siang Boon Koh, Kai Stewart, Nick Haradhvala, Aylin S Dedeoglu, Ilze Smidt, Akiko Suzuki, David Li, Win Thant, Sarah Mueller, Taisha Joseph, Veerle Bossuyt, Michael Lawrence, Gad Getz, Leif W. Ellisen. Genomics and transcriptomics profiling of BRCA mutation carriers revealed the landscape of early pathogenesis of BRCA1/2-associated breast cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 767.
Abstract 907: Evaluation of the anti-GPC1 scFv-Fc fusion protein as a detection tool of GPC1 expression in human cancers
Authors: Sawada Takeshi , Yaguchi Tomonori , Sakai Yuko , Suzuki Chinatsu , Morii Kenji , Aoki Masahiko , Fukahori Masaru , Serada Satoshi , Naka Tetsuji , Yamashita Jun K. , Kawakami Yutaka , Nakajima Takako E. 
Published: April 2023

Abstract
Background: We have developed a glypican-1 (GPC1) targeted CAR-T cell with strong anti-tumor effects against solid tumors in vivo (Kato et al 2020 eLife). In general, an antibody is used for detection of target protein expression in the tumor to identify appropriate targets for the CAR-T cell therapy in solid tumors. However, the local conjunction between CAR-T cells and the target is not exactly the same in the antibody and the target because CAR-T cell recognizes the target by single-chain variable fragment (scFv). In this study, we evaluated the anti-GPC1 scFv-Fc fusion protein as a detection tool of GPC1 expression in human cancer cell lines.
Methods: The sequences encoding the anti-GPC1 scFv are based on the sequence of anti-GPC1 mAb (clone: 1-12) that recognizes human and mouse GPC1 (Harada et al., 2017). The sequences of anti GPC-1 scFv were cloned into pCAG-Neo mIgG2a-Fc plasmid for the generation of anti GPC1_scFv-mIgG2a_Fc fusion proteins. The plasmids were transfected into 293 T cells and the fusion proteins were purified from their culture supernatants using Antibody TCS Purification Kit. LK2-GPC1 (a GPC1 overexpressing lung carcinoma cell line), TE8 (an esophageal carcinoma cell line with endogenous GPC1) and LK2-mock (a GPC1-negative lung carcinoma cell line) were used for the evaluation of the anti-GPC1 scFv-Fc fusion protein.
Results: In FACS assays, fluorescence microscopy analysis and immunohistochemistry staining, GPC1 expression was successfully detected by both anti-GPC1 scFv of VL-VH and VH-VL in LK2-GPC1 and TE-8, and not detected in LK2-mock. Localization of GPC1 expression on the cell membrane was confirmed by fluorescence microscopy.
Perspective: Further comparative evaluation between anti-GPC1 antibody and anti-GPC1 scFv-Fc fusion proteins are needed especially in human tumor tissues. We plan to evaluate a relationship between GPC1 positivity in various human tumor tissues detected by anti-GPC1 scFv-Fc fusion protein and CAR-T cell cytotoxicity against the tissue.
Citation Format: Takeshi Sawada, Tomonori Yaguchi, Yuko Sakai, Chinatsu Suzuki, Kenji Morii, Masahiko Aoki, Masaru Fukahori, Satoshi Serada, Tetsuji Naka, Jun K. Yamashita, Yutaka Kawakami, Takako E. Nakajima. Evaluation of the anti-GPC1 scFv-Fc fusion protein as a detection tool of GPC1 expression in human cancers [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 907.
Supplementary Figure S4 from MST1 Suppresses Pancreatic Cancer Progression via ROS-Induced Pyroptosis
Authors: Cui Jiujie , Zhou Zhuqing , Yang Haiyan , Jiao Feng , Li Ning , Gao Yong , Wang Liwei , Chen Jingde , Quan Ming 
Published: April 2023

<p>Supplementary Figure S4. ROS induces activation of caspase-1 in PDAC. BxPC-3 and FG cells were incubated with 0 mM, 15ï�­M and 30ï�­M H2O2 for 24hours. The levels of cl.caspase-1, mature-IL-1ï�¢ï€ andï€ mature-IL-18 were tested by western blot.</p>
Atuação da fisioterapia aquática na esclerose lateral amiotrófica: revisão integrativa da literatura
Authors: Nishida Márjory Harumi , Saito Ana Paula Midori Sinzato , Braga Douglas Martins , Freire Fernando César , Silva Rafael Santos Ferreira da 
Published: April 2023

A Esclerose Lateral Amiotrófica (ELA) é uma doença neurodegenerativa do sistema nervoso central, caracterizada pela rápida progressão e incapacidade, resultando em atrofia muscular, fraqueza generalizada e fasciculações, marcada pelo acometimento bulbar, ocasionando disartria, disfagia e desconforto respiratório. Objetivo: Avaliar por meio de uma revisão integrativa da literatura a intervenção da fisioterapêutica aquática na esclerose lateral amiotrófica. Métodos: Consiste em uma revisão integrativa desenvolvida com base na estratégia PICO e registrada na plataforma PROSPERO – International prospective register of systematic reviews, 2020, seguindo as recomendações do checklist da PRISMA, abrangendo a leitura, análise e interpretação de artigos publicados na integra, em periódicos científicos disponibilizados em seu formato online, nos idiomas inglês e português, nas bases de dados Pubmed, Medline, Cochrane Library e Physiotherapy Evidence Database (PEDro), que abordaram a atuação da fisioterapia aquática apresentando seus resultados e condutas adotadas. Resultados: Dos 1.093 artigos encontrados, 5 foram selecionados para essa revisão, sendo respectivamente: 01 estudo randomizado com grupo de 22 pessoas; 02 estudos de caso com 1 pessoa, em cada estudo, do sexo masculino; 01 revisão sistemática da literatura, identificando 31 estudos que avaliaram o uso da fisioterapia aquática como tratamento em uma das quatro condições neurológicas, visão geral dos efeitos do treinamento físico em ratos e pacientes afetados pela ELA, através de uma revisão da literatura. Conclusão: Os estudos demostram que a fisioterapia aquática tem um futuro promissor, podendo ser considerado um importante recurso terapêutico para os pacientes com ELA, beneficiando tanto as questões motoras funcionais, como osaspectos psicológicos e sociais.
Ovariectomy Via 12/15-lipoxygenase Augments Angiotensin II-Induced Hypertension and Its Pathogenesis in Female Mice
Authors: Dutta Shubha R. , Singh Purnima , Malik Kafait U. 
Published: April 2023

Background:
Ang II (angiotensin II) releases arachidonic acid from tissue phospholipids that is metabolized by 12/15-lipoxygenase (ALOX15), generating 12(S)- and 15(S)-hydroxyeicosatetraenoic acid (HETE), which have been implicated in cardiovascular and renal diseases. In this study, we tested the hypothesis that ovariectomy augments Ang II-induced hypertension and renal pathophysiological changes via ALOX15 activation in female mice.

Methods:

Ang II (700 ng/kg/min) was infused subcutaneously by osmotic pumps for 2 weeks in intact and ovariectomized wild-type and
Alox15
knockout (ALOX15KO) female mice for evaluation of hypertension and associated pathogenesis.

Results:

Ang II increased blood pressure, impaired autonomic function, and increased renal reactive oxygen species production and plasma 12(S)-HETE level without altering renal function in intact wild-type mice. However, in OVX-wild-type mice with depleted plasma 17β-estradiol, the effects of Ang II on blood pressure, autonomic impairment, renal reactive oxygen species production, and plasma 12(S)- but not 15(S)-HETE was markedly enhanced. In OVX-wild-type mice, Ang II also increased renal
alox15
mRNA, urine 12(S)-HETE, water intake, urine output, decreased osmolality, increased urinary excretion of vasopressin prosegment copeptin, protein/creatinine ratio, and caused renal hypertrophy, fibrosis, and inflammation. These effects of Ang II were attenuated in ALOX15KO mice.

Conclusions:
These data suggest that 17β-estradiol protects against Ang II-induced hypertension and associated pathogenesis in female mice, most likely via inhibition of ALOX15-arachidonic acid derived production of 12(S)-HETE. Therefore, the selective inhibitors of ALOX15 or 12(S)-HETE receptor antagonists could be useful for treating hypertension and its pathogenesis in postmenopausal, hypoestrogenic women, or females with ovarian failure.
Latin American Development in Historical Perspective
Authors: Grinberg Nicolás 
Published: April 2023

Abstract
The paper challenges mainstream theories of Latin American development, showing their theoretical weaknesses and pointing to their role in ideologically mediating the region’s ‘truncated’ capitalism. To that end, the paper presents an alternative view of Latin American development that starts by considering capitalist social reproduction as a worldwide process and regional/national politico-economic development as mediations in the structuring of global capital accumulation. Latin America’s specific variety of capitalism is understood to have emerged from its original transformation by expanding European capital into a place to produce raw materials under favourable natural conditions. On the one hand, this has reduced their price and that of the labour-power directly or indirectly consuming them; on the other, it has resulted in a flow of surplus-value towards the owners of those natural conditions of production. The historical development of Latin American societies has expressed the partial overcoming of that antagonistic relationship between rent-paying capital and rent-appropriating landed property.
Health of the Judiciary in a Democratizing Nigeria: Still Gasping for Breath?
Authors: Basiru Adeniyi S. , Arogundade Martins A. 
Published: April 2023

Abstract
While the Judiciary has continued to play a major role in Nigeria’s democratic journey, yet critical studies on the terrains of judicial independence remains scanty. It is against this background that this article, based on desk analysis, critically examines the health of the Judiciary in a democratizing Nigeria, through the prism of judicial independence. It notes that despite the institutional frameworks, embedded in the 1999 Constitution (as amended) to provide a well-ventilated environment for its existence, the Judiciary, even though still breathing, is still gasping for breath. It argues that this is unconnected to the internal contradictions within the Judiciary and pervasive prebendal culture, which have all interacted to shape the content and terrains of judicial independence in a democratizing Nigeria. The article concludes that as long as the Judiciary in Nigeria continues to be mired in internal contradictions from within, its journey towards achieving institutional independence would remain tortuous.
Hypholoma himalayense, a new and noteworthy species from the Himalayan moist temperate forests of Pakistan
Authors: AYYUB MISBAH , NIAZI ABDUL REHMAN 
Published: April 2023

Hypholoma himalayense, a new species is described and illustrated from the Himalayan moist temperate forests of Pakistan. This new taxon can be differentiated from close allies by its reddish-orange to light orange pileus, light yellowish to dull brown lamellae, and larger and broader basidiospores. The new species is also supported by molecular phylogenetic analysis inferred from the internal transcribed spacer (ITS) region.
Structural Forecasting for Short-Term Tropical Cyclone Intensity Guidance
Authors: McNeely Trey , Khokhlov Pavel , Dalmasso Niccolò , Wood Kimberly M. , Lee Ann B. 
Published: April 2023

Abstract
Because geostationary satellite (Geo) imagery provides a high temporal resolution window into tropical cyclone (TC) behavior, we investigate the viability of its application to short-term probabilistic forecasts of TC convective structure to subsequently predict TC intensity. Here, we present a prototype model that is trained solely on two inputs: Geo infrared imagery leading up to the synoptic time of interest and intensity estimates up to 6 h prior to that time. To estimate future TC structure, we compute cloud-top temperature radial profiles from infrared imagery and then simulate the evolution of an ensemble of those profiles over the subsequent 12 h by applying a deep autoregressive generative model (PixelSNAIL). To forecast TC intensities at hours 6 and 12, we input operational intensity estimates up to the current time (0 h) and simulated future radial profiles up to +12 h into a “nowcasting” convolutional neural network. We limit our inputs to demonstrate the viability of our approach and to enable quantification of value added by the observed and simulated future radial profiles beyond operational intensity estimates alone. Our prototype model achieves a marginally higher error than the National Hurricane Center’s official forecasts despite excluding environmental factors, such as vertical wind shear and sea surface temperature. We also demonstrate that it is possible to reasonably predict short-term evolution of TC convective structure via radial profiles from Geo infrared imagery, resulting in interpretable structural forecasts that may be valuable for TC operational guidance.

Significance Statement
This work presents a new method of short-term probabilistic forecasting for tropical cyclone (TC) convective structure and intensity using infrared geostationary satellite observations. Our prototype model’s performance indicates that there is some value in observed and simulated future cloud-top temperature radial profiles for short-term intensity forecasting. The nonlinear nature of machine learning tools can pose an interpretation challenge, but structural forecasts produced by our model can be directly evaluated and, thus, may offer helpful guidance to forecasters regarding short-term TC evolution. Since forecasters are time limited in producing each advisory package despite a growing wealth of satellite observations, a tool that captures recent TC convective evolution and potential future changes may support their assessment of TC behavior in crafting their forecasts.
Validation of the Post-Traumatic Growth Inventory in Adolescents Who Lost a Family Member in the Past 4 years: Effects of Time After the Death Event and Gender
Authors: Ramos-Vera Cristian , O’Diana Angel García , Vallejos-Saldarriaga José , Saintila Jacksaint 
Published: April 2023

Post-traumatic growth is the psychological capacity to perceive positive changes facing high-stress or potentially traumatic events and may be especially useful in lessening their effects in adolescents’ lives. Present study aimed to evaluate the psychometric properties of the Post-Traumatic Growth Inventory (PTGI) in 662 Peruvian adolescents who suffered the death of an immediate family member over the last 4 years. Firstly, an exploratory graphical analysis (EGA) was conducted to determine the best parsimonious structure of the instrument and confirmed with its respective factor models. The results report adequate fit indices in the EGA Bifactor model. Furthermore, another structural model is included, which reports significant latent effects of the time elapsed since the relative’s death and gender (male) on PTGI general factor. Likewise, gender measure was significantly related to items 3, 7, and 11, which is linked to personal growth.
Commonwealth Power to Improve Access, Quality, and Efficiency of Medical Care: Does section 51 (xxiiiA) of the Constitution Limit Politically Feasible Health Policy Options Today?
Authors: McDonald Fiona , Duckett Stephen , Campbell Emma 
Published: April 2023

AbstractLegal and political battles about health policy in the immediate post-war years have cast a long shadow in Australia. The ‘civil conscription’ sub-provision in s 51(xxiiiA) (health and welfare power) of the Australian Constitution is still cited as a major barrier to developing health policy. But long after the High Court moved on from a very restrictive interpretation of Commonwealth powers, policymakers appear to be cautious about testing whether the Commonwealth has power to make laws about medical services to pursue a bold agenda about access, quality, and efficiency of medical care. In this article we will first describe the origin and phrasing of s 51(xxiiiA), the main head of power, then trace the development of the interpretation of the civil conscription sub-provision, and finally discuss whether politically realistic policy options are likely to founder on the shoals of High Court interpretation. We argue that the civil conscription limitation in s 51 (xxiiiA) in the Constitution looms larger as a policy constraint on regulation of health care by the Commonwealth government in the minds of decision-makers, and as a weapon in the hands of stakeholders, than contemporary analysis of it warrants.
IFN-γ blockade after genetic inhibition of PD-1 aggravates skeletal muscle damage and impairs skeletal muscle regeneration
Authors: Zhuang Shuzhao , Russell Aaron , Guo Yifan , Xu Yingying , Xiao Weihua 
Published: April 2023

Abstract
Background
Innate immune responses play essential roles in skeletal muscle recovery after injury. Programmed cell death protein 1 (PD-1) contributes to skeletal muscle regeneration by promoting macrophage proinflammatory to anti-inflammatory phenotype transition. Interferon (IFN)-γ induces proinflammatory macrophages that appear to hinder myogenesis in vitro. Therefore, we tested the hypothesis that blocking IFN-γ in PD-1 knockout mice may dampen inflammation and promote skeletal muscle regeneration via regulating the macrophage phenotype and neutrophils.

Methods
Anti-IFN-γ antibody was administered in PD-1 knockout mice, and cardiotoxin (CTX) injection was performed to induce acute skeletal muscle injury. Hematoxylin and eosin (HE) staining was used to view morphological changes of injured and regenerated skeletal muscle. Masson’s trichrome staining was used to assess the degree of fibrosis. Gene expressions of proinflammatory and anti-inflammatory factors, fibrosis-related factors, and myogenic regulator factors were determined by real-time polymerase chain reaction (PCR). Changes in macrophage phenotype were examined by western blot and real-time PCR. Immunofluorescence was used to detect the accumulation of proinflammatory macrophages, anti-inflammatory macrophages, and neutrophils.

Results
IFN-γ blockade in PD-1 knockout mice did not alleviate skeletal muscle damage or improve regeneration following acute cardiotoxin-induced injury. Instead, it exacerbated skeletal muscle inflammation and fibrosis, and impaired regeneration via inhibiting macrophage accumulation, blocking macrophage proinflammatory to anti-inflammatory transition, and enhancing infiltration of neutrophils.

Conclusion
IFN-γ is crucial for efficient skeletal muscle regeneration in the absence of PD-1.