bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prediction of upcoming urinary tract infection after intracerebral hemorrhage: a machine learning approach based on statistics collected at multiple time points
Authors: Zhao Yanjie , Chen Chaoyue , Huang Zhouyang , Wang Haoxiang , Tie Xin , Yang Jinhao , Cui Wenyao , Xu Jianguo 
Published: September 2023

PurposeAccurate prediction of urinary tract infection (UTI) following intracerebral hemorrhage (ICH) can significantly facilitate both timely medical interventions and therapeutic decisions in neurocritical care. Our study aimed to propose a machine learning method to predict an upcoming UTI by using multi-time-point statistics.MethodsA total of 110 patients were identified from a neuro-intensive care unit in this research. Laboratory test results at two time points were chosen: Lab 1 collected at the time of admission and Lab 2 collected at the time of 48 h after admission. Univariate analysis was performed to investigate if there were statistical differences between the UTI group and the non-UTI group. Machine learning models were built with various combinations of selected features and evaluated with accuracy (ACC), sensitivity, specificity, and area under the curve (AUC) values.ResultsCorticosteroid usage (p &lt; 0.001) and daily urinary volume (p &lt; 0.001) were statistically significant risk factors for UTI. Moreover, there were statistical differences in laboratory test results between the UTI group and the non-UTI group at the two time points, as suggested by the univariate analysis. Among the machine learning models, the one incorporating clinical information and the rate of change in laboratory parameters outperformed the others. This model achieved ACC = 0.773, sensitivity = 0.785, specificity = 0.762, and AUC = 0.868 during training and 0.682, 0.685, 0.673, and 0.751 in the model test, respectively.ConclusionThe combination of clinical information and multi-time-point laboratory data can effectively predict upcoming UTIs after ICH in neurocritical care.
Optimizing vestibular neuritis management with modular strategies
Authors: Li Fei , Xu Jin , Liu Dan , Wang Jun , Lu Lingmei , Gao Rui , Zhou Xiaowen , Zhuang Jianhua , Zhang Sulin 
Published: September 2023

ObjectiveThis study proposes a “modular management” approach for vestibular neuritis (VN) to reduce chronicization and improve patient prognosis. The approach involves multi-factor grading and hierarchical intervention and was found to be more effective than traditional treatment strategies.MethodsThis retrospective analysis compared two groups of VN patients from two medical institutions. The intervention group of 52 patients received “modular management,” while the control group of 51 patients did not receive this kind of management. Analyzed the early treatment strategies, 6-month prognosis, and other indicators of the two groups of patients, compared and analyzed their overall prognosis, and identified the risk factors affecting the chronicization.ResultsThe modular management group had lower dizziness severity, better balance, lower anxiety, and higher video head impulse testing (v-HIT) gain after 6 months of onset. Analysis of factors related to persistent postural-perceptual dizziness (PPPD) in patients with VN showed positive correlations between the time from onset to diagnosis and PPPD, and Vertigo Symptom Scale (VSS), Dizziness Handicap Inventory (DHI), anxiety, and depression. Normalized vestibular rehabilitation was negatively correlated with PPPD, while gender, age, and early steroid use had no significant correlation. The multi-factor logistic regression model correctly classified 93.20% of the study subjects with a sensitivity of 87.50% and specificity of 94.90%.ConclusionThe proposed “modular management” scheme for VN is a comprehensive and dynamic approach that includes health education, assessment, rehabilitation, therapy, evaluation, and prevention. It can significantly improve patient prognosis and reduce chronicization by shifting from simple acute treatment to continuous management.
Perioperative cerebral blood flow measured by arterial spin labeling with different postlabeling delay in patients undergoing carotid endarterectomy: a comparison study with CT perfusion
Authors: Xu Huimin , Han Hualu , Liu Ying , Huo Ran , Lang Ning , Yuan Huishu , Wang Tao , Zhao Xihai 
Published: September 2023

BackgroundArterial spin labeling (ASL) is a non-invasive technique for measuring cerebral perfusion. Its accuracy is affected by the arterial transit time. This study aimed to (1) evaluate the accuracy of ASL in measuring the cerebral perfusion of patients who underwent carotid endarterectomy (CEA) and (2) determine a better postlabeling delay (PLD) for pre- and postoperative perfusion imaging between 1.5 and 2.0 s.MethodsA total of 24 patients scheduled for CEA due to severe carotid stenosis were included in this study. All patients underwent ASL with two PLDs (1.5 and 2.0 s) and computed tomography perfusion (CTP) before and after surgery. Cerebral blood flow (CBF) values were measured on the registered CBF images of ASL and CTP. The correlation in measuring perioperative relative CBF (rCBF) and difference ratio of CBF (DRCBF) between ASL with PLD of 1.5 s (ASL1.5) or 2.0 s (ASL2.0) and CTP were also determined.ResultsThere were no significant statistical differences in preoperative rCBF measurements between ASL1.5 and CTP (p = 0.17) and between ASL2.0 and CTP (p = 0.42). Similarly, no significant differences were found in rCBF between ASL1.5 and CTP (p = 0.59) and between ASL2.0 and CTP (p = 0.93) after CEA. The DRCBF measured by CTP was found to be marginally lower than that measured by ASL2.0_1.5 (p = 0.06) and significantly lower than that measured by ASL1.5_1.5 (p = 0.01), ASL2.0_2.0 (p = 0.03), and ASL1.5_2.0 (p = 0.007). There was a strong correlation in measuring perioperative rCBF and DRCBF between ASL and CTP (r = 0.67–0.85, p &lt; 0.001). Using CTP as the reference standard, smaller bias can be achieved in measuring rCBF by ASL2.0 (−0.02) than ASL1.5 (−0.07) before CEA. In addition, the same bias (0.03) was obtained by ASL2.0 and ASL1.5 after CEA. The bias of ASL2.0_2.0 (0.31) and ASL2.0_1.5 (0.32) on DRCBF measurement was similar, and both were smaller than that of ASL1.5_1.5 (0.60) and ASL1.5_2.0 (0.60).ConclusionStrong correlation can be found in assessing perioperative cerebral perfusion between ASL and CTP. During perioperative ASL imaging, the PLD of 2.0 s is better than 1.5 s for preoperative scan, and both 1.5 and 2.0 s are suitable for postoperative scan.
Wearable rehabilitation wristband for distal radius fractures
Authors: Zha Qing , Xu Zeou , Cai Xuefeng , Zhang Guodong , Shen Xiaofeng 
Published: September 2023

BackgroundDistal radius fractures are a common type of fracture. For patients treated with closed reduction with splinting, a period of rehabilitation is still required after the removal of the splint. However, there is a general lack of attention and low compliance to rehabilitation training during this period, so it is necessary to build a rehabilitation training monitoring system to improve the efficiency of patients’ rehabilitation.MethodsA wearable rehabilitation training wristband was proposed, which could be used in the patient’s daily rehabilitation training scenario and could recognize four common wrist rehabilitation actions in real-time by using three thin film pressure sensors to detect the pressure change curve at three points on the wrist. An algorithmic framework for classifying rehabilitation training actions was proposed. In our framework, an action pre-detection strategy was designed to exclude false detections caused by switching initial gestures during rehabilitation training and wait for the arrival of the complete signal. To classify the action signals into four categories, firstly an autoencoder was used to downscale the original signal. Six SVMs were then used for evaluation and voting, and the final action with the highest number of votes would be used as the prediction result.ResultsExperimental results showed that the proposed algorithmic framework achieved an average recognition accuracy of 89.62%, an average recognition recall of 88.93%, and an f1 score of 89.27% on the four rehabilitation training actions.ConclusionThe developed device has the advantages of being small size and easy to wear, which can quickly and accurately identify and classify four common rehabilitation training actions. It can easily be combined with peripheral devices and technologies (e.g., cell phones, computers, Internet) to build different rehabilitation training scenarios, making it worthwhile to use and promote in clinical settings.
Bacterial extracellular vesicles – brain invaders? A systematic review
Authors: Kaisanlahti Anna , Salmi Sonja , Kumpula Sohvi , Amatya Sajeen Bahadur , Turunen Jenni , Tejesvi Mysore , Byts Nadiya , Tapiainen Terhi , Reunanen Justus 
Published: September 2023

IntroductionKnowledge on the human gut microbiota in health and disease continues to rapidly expand. In recent years, changes in the gut microbiota composition have been reported as a part of the pathology in numerous neurodegenerative diseases. Bacterial extracellular vesicles (EVs) have been suggested as a novel mechanism for the crosstalk between the brain and gut microbiota, physiologically connecting the observed changes in the brain to gut microbiota dysbiosis.MethodsPublications reporting findings on bacterial EVs passage through the blood–brain barrier were identified in PubMed and Scopus databases.ResultsThe literature search yielded 138 non-duplicate publications, from which 113 records were excluded in title and abstract screening step. From 25 publications subjected to full-text screening, 8 were excluded. The resulting 17 publications were considered for the review.DiscussionBacterial EVs have been described with capability to cross the blood–brain barrier, but the mechanisms behind the crossing remain largely unknown. Importantly, very little data exists in this context on EVs secreted by the human gut microbiota. This systematic review summarizes the present evidence of bacterial EVs crossing the blood–brain barrier and highlights the importance of future research on gut microbiota-derived EVs in the context of gut-brain communication across the blood–brain barrier.
Lifestyle and the risk of acute coronary event: a retrospective study of patients after myocardial infarction
Authors: Szczepańska Elżbieta , Białek-Dratwa Agnieszka , Filipów Katarzyna , Kowalski Oskar 
Published: September 2023

IntroductionUnhealthy lifestyle behaviours that may contribute to the development of disorders leading to MI include consuming foods with a high glycaemic load and excessive supply of saturated fats, especially trans fats. Limiting the consumption of simple and refined carbohydrates, such as sweets, sweet drinks, white bread, or white pasta, has a positive effect on the lipid profile by lowering the concentration of triglycerides. Eliminating simple sugars, especially fructose, prevents the deposition of visceral adipose tissue.Materials and methodsThe study included 116 patients of the Silesian Centre for Heart Diseases in Zabrze (SCCS; Poland), with their average age being 59.45 ± 11.54 years, staying in the SCCS due to MI, from March to November 2022. The comprehensive assessment of diet quality included 72 patients: 15 women and 57 men. The research tool was the KomPAN questionnaire for examining dietary views and habits, developed by the Committee on Human Nutrition Science of the Polish Academy of Sciences, evaluating the diet in the year preceding the study. The following three indicators were used to assess the diet quality: pro-Healthy Diet Index (pHDI), non-Healthy Diet Index (nHDI) and Diet Quality Index (DQI).ResultsMost patients ate white wheat bread several times a day (39.66% of patients, with a higher percentage in men than in women – 42.35% vs. 32.26%), and white rice, fine-ground groats and pasta once a week (40.52% of patients, including 41.17% of men and 38.71% of women). Legume seeds were predominantly eaten 1–3 times a month (51.73% of responses, with comparable percentages of men and women, i.e., 51.76% vs. 51.62%), vegetables several times a week (42.25% of responses, including more women than men, i.e., 54.84% vs. 37.64%), and fruit once a day (40.52% of responses, including more men than women: 45.89% vs. 25.81%).ConclusionThe results of our assessment of individual behaviours of the whole group may indicate errors in the diet. The value of the pro-Healthy Diet Index appears to confirm this fact, while the non-Healthy Diet Index and Diet Quality Index values do not clearly demonstrate its potential adverse impact on health. These limitations of our study may be due to differences in the size of the study population and the size of the population included in the comprehensive diet assessment. Therefore, it seems necessary to conduct further research.
A randomized trial involving a multifunctional diet reveals systematic lipid remodeling and improvements in cardiometabolic risk factors in middle aged to aged adults
Authors: Arroyo Claudia Balderas , Ocariz Maider Greño , Rogova Oksana , Al-Majdoub Mahmoud , Björck Inger , Tovar Juscelino , Spégel Peter 
Published: September 2023

BackgroundA multifunctional diet (MFD) combining foods and ingredients with proven functional properties, such as fatty fish and fiber-rich foods, among others, was developed and shown to markedly reduce cardiometabolic risk-associated factors.ObjectiveHere, we aim at examining metabolic physiological changes associated with these improvements.MethodsAdult overweight individuals without other risk factors were enrolled in an 8-week randomized controlled intervention following a parallel design, with one group (n = 23) following MFD and one group (n = 24) adhering to a control diet (CD) that followed the caloric formula (E%) advised by the Nordic Nutritional Recommendations. Plasma metabolites and lipids were profiled by gas chromatography and ultrahigh performance liquid chromatography/mass spectrometry.ResultsWeight loss was similar between groups. The MFD and CD resulted in altered levels of 137 and 78 metabolites, respectively. Out of these, 83 were uniquely altered by the MFD and only 24 by the CD. The MFD-elicited alterations in lipid levels depended on carbon number and degree of unsaturation.ConclusionAn MFD elicits weight loss-independent systematic lipid remodeling, promoting increased circulating levels of long and highly unsaturated lipids.Clinical trial registrationhttps://clinicaltrials.gov/ct2/show/NCT02148653?term=NCT02148653&amp;draw=2&amp;rank=1, NCT02148653.
Single nucleotide polymorphisms and sickle cell disease-related pain: a systematic review
Authors: Gehling Gina M. , Powell-Roach Keesha , Wilkie Diana J. , Dungan Jennifer R. 
Published: September 2023

BackgroundScientists have speculated genetic variants may contribute to an individual's unique pain experience. Although research exists regarding the relationship between single nucleotide polymorphisms and sickle cell disease-related pain, this literature has not been synthesized to help inform future precision health research for sickle cell disease-related pain. Our primary aim of this systematic review was to synthesize the current state of scientific literature regarding single nucleotide polymorphisms and their association with sickle cell disease-related pain.MethodsUsing the Prisma guidelines, we conducted our search between December 2021–April 2022. We searched PubMed, Web of Science, CINAHL, and Embase databases (1998–2022) and selected all peer-reviewed articles that included reports of associations between single nucleotide polymorphisms and sickle cell disease-related pain outcomes.ResultsOur search yielded 215 articles, 80 of which were duplicates, and after two reviewers (GG, JD) independently screened the 135 non-duplicate articles, we retained 22 articles that met the study criteria. The synthesis of internationally generated evidence revealed that this scientific area remains predominantly exploratory in nature, with only three studies reporting sufficient power for genetic association. Sampling varied across studies with a range of children to older adults with SCD. All of the included articles (n = 22) examined acute pain, while only nine of those studies also examined chronic pain.ConclusionCurrently, the evidence implicating genetic variation contributing to acute and chronic sickle cell disease-related pain is characterized by modestly powered candidate-gene studies using rigorous SCD-pain outcomes. Effect sizes and directions vary across studies and are valuable for informing the design of future studies. Further research is needed to replicate these associations and extend findings with hypothesis-driven research to inform precision health research.
Differential effects of cow dung and its biochar on Populus euphratica soil phosphorus effectiveness, bacterial community diversity and functional genes for phosphorus conversion
Authors: Fan Yuxian , Lv Guanghui , Chen Yudong , Chang Yaling , Li Zhoukang 
Published: September 2023

IntroductionContinuous monoculture leading to soil nutrient depletion may cause a decline in plantation productivity. Cow dung is typically used as a cheap renewable resource to improve soil nutrient status. In this study, our purpose was to compare the effects of different cow dung return methods (direct return and carbonization return) on soil microbial communities and phosphorus availability in the root zone (rhizosphere soil and non-rhizosphere soil) of P.euphratica seedlings in forest gardens and to explore possible chemical and microbial mechanisms.MethodsField experiments were conducted. Two-year-old P.euphratica seedlings were planted in the soil together with 7.5 t hm-2 of cow dung and biochar made from the same amount of cow dung.ResultsOur findings indicated that the available phosphorus content in soil subjected to biochar treatment was considerably greater than that directly treated with cow dung, leading to an increase in the phosphorus level of both aboveground and underground components of P.euphratica seedlings. The content of Olsen-P in rhizosphere and non-rhizosphere soil increased by 134% and 110%, respectively.This was primarily a result of the direct and indirect impact of biochar on soil characteristics. Biochar increased the biodiversity of rhizosphere and non-rhizosphere soil bacteria compared with the direct return of cow dung. The Shannon diversity index of carbonized cow manure returning to field is 1.11 times and 1.10 times of that of direct cow manure returning to field and control, and the Chao1 diversity index is 1.20 times and 1.15 times of that of direct cow manure returning to field and control.Compared to the direct addition of cow dung, the addition of biochar increased the copy number of the phosphorus functional genes phoC and pqqc in the rhizosphere soil. In the biochar treatment, the abundance of the phosphate-solubilizing bacteria Sphingomonas and Lactobacillus was significantly higher than that in the other treatments, it is relative abundance was 4.83% and 2.62%, respectively, which indirectly improved soil phosphorus availability.DiscussionThe results indicated that different cow dung return methods may exert different effects on phosphorus availability in rhizosphere and non-rhizosphere soils via chemical and microbial pathways. These findings indicated that, compared to the direct return of cow dung, biochar return may exert a more significant impact on the availability of phosphorus in both rhizosphere and non-rhizosphere soils, as well as on the growth of P.euphratica seedlings and the microbial community.
Oxytocin levels and self-reported anxiety during interactions between humans and cows
Authors: Berget Bente , Vas Judit , Pedersen Gunn , Uvnäs-Moberg Kerstin , Newberry Ruth C. 
Published: September 2023

IntroductionPositive social interactions with farm animals may have therapeutic benefits on humans by increasing brain oxytocin secretion, as inferred from circulating oxytocin levels. The aim of this observational study was to investigate acute changes in human plasma oxytocin levels and state anxiety associated with interactions with dairy cows.MethodsData were collected from 18 healthy female nursing students who performed stroking and brushing of an unfamiliar cow for 15 min. Blood samples were drawn before entering the cowshed (T1, baseline), and after 5 (T2) and 15 (T3) min of interaction with a cow. At T1 and T3, the students filled out the Norwegian version of the Spielberger State-Trait Anxiety Inventory-State Subscale (STAI-SS).ResultsAcross participants, no significant changes in average plasma oxytocin concentration were detected between time points (p&gt;0.05). There was, however, a modest decline in the STAI-SS scores between T1 and T3 (p=0.015) and a positive correlation between the change in individual level of state anxiety between T1 and T3 and the change in OT concentration of the same individual between T2 and T3 (p = 0.045).DiscussionThe results suggest that friendly social interactions with cows are beneficial in lowering state anxiety, but any relationship with release of OT into the circulation was complex and variable across individuals. The acute reduction in state anxiety lends support to the value of interacting with farm animals in the context of Green Care for people with mental health challenges.
Beliefs about mental health in incarcerated males: a qualitative interview study
Authors: Solbakken Line Elisabeth , Bergvik Svein , Wynn Rolf 
Published: September 2023

IntroductionBeliefs about mental health are shaped by the sociocultural context. Prisons have unique environmental and social features, and the prevalence of mental health problems in incarcerated populations is exceptionally high. These features make prisons especially interesting settings for exploring health beliefs. The aim of this study was to explore the conceptualizations of mental health and coping preferences in a prison environment.MethodsIndividual in-depth interviews were conducted with fifteen incarcerated males from three prisons in Northern Norway. The design draws on central elements from Grounded Theory.ResultsMental health was perceived as distinct from mental illness by many of the participants. They coped with the prison environment by focusing on the things that gave them a sense of meaning and autonomy – this also formed their conceptualization of mental health. Furthermore, social interaction and activities were perceived as important to enhance and maintain mental well-being, however there were institutional barriers to using these coping strategies. The prison environment was integrated in the participants conceptualizations of mental health problems, and psychosocial stressors were emphasized in causal attributions. Biological and dispositional factors were less frequently mentioned. The participants preferred non-medical management for mental health problems and most displayed a reserved attitude towards psychotropic medications. The exception was attention-deficit hyperactivity disorder, for which they held neurobiological causal beliefs, together with a corresponding preference for medication as treatment.ConclusionThe main finding was a firm integration of the prison context in in the participants’ beliefs about mental health. We theorize that fusion of prison conditions and mental health beliefs were brought on by the processes of prisonization, observing mental distress in peers and attempts to protect self-esteem by externalizing the causes for mental health problems. Access to activities, social time, and “someone to talk to” were perceived to be crucial for improving and preserving mental health.