bluuebunny/crossref_metadata_2025_split huggingface dataset:
Post Nitrogen Electrocatalysis Era From Li–N2Batteries to Zn–N2Batteries
Authors: Meng Fanbo , Xiong Xingyu , He Shengnan , Liu Yanxia , Hu Renzong 
Published: March 2023

AbstractMetal–N2batteries attract considerable research attention due to the dual‐functional characteristics applied in energy storage and conversion, as well as electrochemical artificial NH3yield. Nonetheless, it has been found that not all kinds of metal–N2batteries are suitable for combining the above two applications. Herein, recent advances in metal–N2batteries are summarized. First, the electrochemical reaction mechanisms for all types of metal–N2batteries, including organic Li/Na/Al–N2batteries and aqueous Zn/Al–N2batteries are discussed, and then, a critical assessment of current challenges and future applications is provided. Considering the different electrochemical reaction mechanism in the metal–N2batteries, the electrocatalytic performance for the reported catalyst cathodes is summarized and compared. Then, a multi‐dimensional feasibility and strategy analysis for the developments of rechargeable aqueous Zn–N2batteries is provided, including the three dimensions of cathode catalyst, electrolyte, and metal anodes. Last, specific suggestions and ideas for the further developments of the rechargeable aqueous Zn–N2batteries are put forward, with the hope of inspiring the further developments for the green, sustainable, and high‐energy‐density metal–N2systems in the future.
Catalytic Defect‐Repairing Using Manganese Ions for Hard Carbon Anode with High‐Capacity and High‐Initial‐Coulombic‐Efficiency in Sodium‐Ion Batteries
Authors: Zhao Jiahua , He Xiang‐Xi , Lai Wei‐Hong , Yang Zhuo , Liu Xiao‐Hao , Li Lin , Qiao Yun , Xiao Yao , Li Li , Wu Xingqiao , Chou Shu‐Lei 
Published: March 2023

AbstractHard carbon (HC) anodes have shown extraordinary promise for sodium‐ion batteries, but are limited to their poor initial coulombic efficiency (ICE) and low practical specific capacity due to the large amount of defects. These defects with oxygen containing groups cause irreversible sites for Na+ ions. Highly graphited carbon decreases defects, while potentially blocking diffusion paths of Na+ ions. Therefore, molecular‐level control of graphitization of hard carbon with open accessible channels for Na+ ions is key to achieve high‐performance hard carbon. Moreover, it is challenging to design a conventional method to obtain HCs with both high ICE and capacity. Herein, a universal strategy is developed as manganese ions‐assisted catalytic carbonization to precisely tune graphitization degree, eliminate defects, and maintain effective Na+ ions paths. The as‐prepared hard carbon has a high ICE of 92.05% and excellent cycling performance. Simultaneously, a sodium storage mechanism of “adsorption‐intercalation‐pore filling‐sodium cluster formation” is proposed, and a clear description given of the boundaries of the pore structure and the specific dynamic process of pore filling.
Ruthenium‐Catalyzed C−C Coupling of Terminal Alkynes with Primary Alcohols or Aldehydes: α,β‐Acetylenic Ketones (Ynones) via Oxidative Alkynylation
Authors: Ortiz Eliezer , Evarts Madeline M. , Strong Zachary H. , Shezaf Jonathan Z. , Krische Michael J. 
Published: March 2023

AbstractThe first metal‐catalyzed oxidative alkynylations of primary alcohols or aldehydes to form α,β‐acetylenic ketones (ynones) are described. Deuterium labelling studies corroborate a novel reaction mechanism in which alkyne hydroruthenation forms a transient vinylruthenium complex that deprotonates the terminal alkyne to form the active alkynylruthenium nucleophile.
A Glycosidic‐Bond‐Based Mass‐Spectrometry‐Cleavable Cross‐linker Enables In Vivo Cross‐linking for Protein Complex Analysis
Authors: Chen Jing , Zhao Qun , Gao Hang , Zhao Lili , Chu Huiying , Shan Yichu , Liang Zhen , Zhang Yukui , Zhang Lihua 
Published: March 2023

AbstractChemical cross‐linking mass spectrometry (CXMS) has emerged as a powerful technology to analyze protein complexes. However, the progress of in vivo CXMS studies has been limited by cross‐linking biocompatibility and data analysis. Herein, a glycosidic bond‐based MS‐cleavable cross‐linker of trehalose disuccinimidyl ester (TDS) was designed and synthesized, which was fragmented in MS under CID/HCD to simplify the cross‐linked peptides into conventional single peptides via selective cleavage between glycosidic and peptide bonds under individual MS collision energy. Consequently, the cross‐linking identification accuracy and throughput were significantly enhanced, and the popular MS mode of stepped HCD was allowed. In addition, TDS showed proper cell‐penetrating properties while being highly water‐soluble, making it non‐DMSO dependent during solubilization. Collectively, TDS provides a promising toolkit for CXMS characterization of living systems with high biocompatibility and accuracy.
Metal‐Organic Layer Delivers 5‐Aminolevulinic Acid and Porphyrin for Dual‐Organelle‐Targeted Photodynamic Therapy
Authors: Luo Taokun , Fan Yingjie , Mao Jianming , Jiang Xiaomin , Albano Luciana , Yuan Eric , Germanas Tomas , Lin Wenbin 
Published: March 2023

AbstractThe efficacy of photodynamic therapy (PDT) depends on the subcellular localization of photosensitizers. Herein, we report a dual‐organelle‐targeted nanoparticle platform for enhanced PDT of cancer. By grafting 5‐aminolevulinic acid (ALA) to a Hf12‐based nanoscale metal‐organic layer (Hf‐MOL) via carboxylate coordination, ALA/Hf‐MOL enhanced ALA delivery and protoporphyrin IX (PpIX) synthesis in mitochondria, and trapped the Hf‐MOL comprising 5,15‐di‐p‐benzoatoporphyrin (DBP) photosensitizers in lysosomes. Light irradiation at 630 nm simultaneously excited PpIX and DBP to generate singlet oxygen and rapidly damage both mitochondria and lysosomes, leading to synergistic enhancement of the PDT efficacy. The dual‐organelle‐targeted ALA/Hf‐MOL outperformed Hf‐MOL in preclinical PDT studies, with a 2.7‐fold lower half maximal inhibitory concentration in cytotoxicity assays in vitro and a 3‐fold higher cure rate in a colon cancer model in vivo.
Carbazolylene‐Ethynylene Macrocycle based Conductive Covalent Organic Frameworks
Authors: Huang Shaofeng , Choi Ji Yong , Xu Qiucheng , Jin Yinghua , Park Jihye , Zhang Wei 
Published: March 2023

AbstractTwo covalent organic frameworks consisting of carbazolylene‐ethynylene shape‐persistent macrocycles with azine (MC‐COF‐1) or imine (MC‐COF‐2) linkages were synthesized via imine condensation. The obtained 2D frameworks are fully conjugated which imparts semiconducting properties. In addition, the frameworks showed high porosity with aligned accessible porous channels along the z axis, serving as an ideal platform for post‐synthetic incorporation of I2 into the channels to enable electrical conductivity. The resulting MC‐COF‐1 showed an electrical conductivity up to 7.8×10−4 S cm−1 at room temperature upon I2 doping with the activation energy as low as 0.09 eV. Furthermore, we demonstrated that the electrical properties of both MC‐COFs are switchable between electron‐conducting and insulating states by simply implementing doping‐regenerating cycles. The knowledge gained in this study opens new possibilities for the future development of tunable conductive 2D organic materials.
Cationic Rhodium(I) Tetrafluoroborate Catalyzed Intramolecular Carbofluorination of Alkenes via Acyl Fluoride C−F Bond Activation**
Authors: Yoshida Tomoki , Ohta Masaya , Emmei Tomoya , Kodama Takuya , Tobisu Mamoru 
Published: March 2023

AbstractThe C−F bond of acyl fluorides can be cleaved and added across tethered alkenes in the presence of a cationic rhodium(I) tetrafluoroborate catalyst. This 1,2‐carbofluorination reaction offers a powerful method for the synthesis of tertiary alkyl fluoride derivatives with an atom economy of 100 %. Mechanistic studies indicate that the concerted action of a rhodium cation and a tetrafluoroborate anion is key for the success of this catalytic cleavage and formation of C−F bonds in a controlled manner.
Synthesis of chitosan‐nTiO2 nanocomposite, application in adsorptive removal of Cu(II)—Adsorption and desorption study, mechanism, scale‐up design, statistical, and genetic algorithm modeling
Authors: Bhattacharya Samanwita , Bar Nirjhar , Rajbansi Baisali , Das Sudip Kumar 
Published: March 2023

The present study comprises the preparation of chitosan‐nTiO2 nanocomposites and their characterization with the help of scanning electron microscopy (SEM), Brunauer–Emmett–Teller (BET), Fourier transform infrared spectroscopy (FTIR), X‐ray diffraction (XRD), and thermogravimetric analysis (TGA). Various adsorbent samples are prepared with different weight ratios of chitosan to nTiO2. The adsorption capacity of the prepared adsorbents towards Cu(II) in an aqueous solution is also tested. The adsorption experiment is performed in batch mode under varying experimental conditions. Several isotherm and kinetic models are analyzed with the experimental data, and thermodynamic conditions required for adsorption are also determined. The highest elimination of Cu(II) was 39.19% with the adsorbent chitosan without nTiO2 (CWT) with 20 mg L−1 initial Cu (II) concentration at adsorbent dosage 3 gL−1 and 98.5% with the adsorbent CTNC1‐1 (chitosan/nTiO2 nanocomposite with the mass proportions of chitosan:nTiO2 = 1:1) and 93% with CTNC2‐1 (chitosan/nTiO2 nanocomposite with the mass proportions of chitosan:nTiO2 = 2:1) with 10 mg L−1 initial Cu(II) concentration at adsorbent dosage 5 g L−1. The isotherm model confirmed the monolayer adsorption. Maximum Langmuir adsorption capacities (qL) of the adsorbents for Cu(II) were given as CTNC1‐1 > CTNC2‐1 > CWT. The pseudo‐second‐order model excellently depicted the kinetic process with good correlation for all adsorbents. The statistical (R‐square is more than 0.99) and genetic algorithm (GA) model (R‐square is more than 0.99) effectively predicted the percentage removal of Cu(II).
Decarbonizing British Columbia's (BC's) marine sector by using low carbon intensive (CI) biofuels
Authors: Mandegari Mohsen , Ebadian Mahmood , van Dyk Susan , Saddler Jack (John) 
Published: March 2023

AbstractThe long‐distance transport sector will not be easily electrified. Aviation will primarily use sustainable aviation fuels (SAF) to meet its decarbonization targets. Although marine will also be hard to decarbonize this sector has several lower carbon‐intensive (CI) fuel options such as electric‐hybrids, liquefied natural gas (LNG), ‘green’ methanol, ammonia, hydrogen, and biobased fuels. The advantages of using these latter fuels are their ready integration into much of the existing infrastructure, their availability, their use in today's marine engines, substantial carbon emission reductions, and established supply chains. However, there will be increasing competition for the oleochemical/lipid feedstocks from the trucking and aviation sector, while the cost, availability, and overall sustainability of these biofuels are problematic. In the longer term, it is hoped that biomass‐derived biocrudes produced via thermochemical processes such as pyrolysis, hydrothermal liquefaction (HTL) and gasification will supplement the lipid feedstocks and be more sustainable, cheaper, and plentiful. The robustness of marine engines is also conducive to the direct use of straight vegetable oils (SVO) and biocrudes. However, ‘enabling’ policies such as the British Columbia low carbon fuels standard will be required to bridge the initial price gap between fossil and low‐CI fuels while the international nature of most marine traffic will require agreement on how the life cycle analysis (LCA) is determined.
Burden of chemotherapy‐induced myelosuppression among patients with extensive‐stage small cell lung cancer: A retrospective study from community oncology practices
Authors: Hart Lowell , Ogbonnaya Augustina , Boykin Kristen , Deyoung Kathryn , Bailey Ray , Heritage Trevor , Lopez‐Gonzalez Lorena , Huang Huan , Gordan Lucio 
Published: March 2023

AbstractBackgroundMyelosuppression is a major dose‐limiting complication of chemotherapy for patients with extensive‐stage small cell lung cancer (ES‐SCLC). The objective was to describe the burden of myelosuppression, treatment patterns, and supportive care use among patients with ES‐SCLC treated with chemotherapy in a US community oncology setting.MethodsThis retrospective cohort study used structured electronic medical record (EMR) data from the Florida Cancer Specialists & Research Institute between January 2013 and December 2020. Adult patients with ES‐SCLC who were treated with chemotherapy between September 2013 and November 2020 were identified. The index date was the date of the first chemotherapy‐containing line of therapy (LOT). Patients were followed for a minimum of 30 days after index (unless patient died) until December 31, 2020, or end of activity in the EMR data, whichever occurred first. Incidence and frequency of myelosuppressive episodes/events, treatment patterns, eligibility for red blood cell (RBC) or platelet transfusions, and supportive care use (granulocyte colony‐stimulating factor [G‐CSF], erythropoiesis‐stimulating agents [ESAs], intravenous [IV] hydration) during the follow‐up period were reported.ResultsThe study population included 1239 patients. Most (94.0%) patients started first‐line chemotherapy at index. During follow‐up and across all chemotherapy‐containing LOTs, 1222 (98.6%) patients had at least 1 myelosuppressive episode; 62.1% of patients had grade ≥ 3 myelosuppressive episodes in at least one lineage, 33.9% had grade ≥ 3 myelosuppressive episodes in at least two lineages, and 15.5% had grade ≥ 3 myelosuppressive episodes in all three lineages. Supportive care use included 89.7% of patients who received G‐CSF, 24.4% who received ESAs, and 52.1% who received IV volume expansion. Almost one‐third (32.6%) of patients were eligible to receive RBC transfusions based on lab values (hemoglobin < 8 g/dL).ConclusionThere is a high burden related to multilineage myelosuppression among chemotherapy‐treated patients with ES‐SCLC in the community oncology setting. Reducing myelosuppression could make chemotherapy treatment safer, reduce the need for supportive care, and potentially prevent the treatment of complications.
Molecular genetic positioning of small intestine and papilla of Vater carcinomas including clinicopathological classification
Authors: Nakamura Masanori , Okamura Yukiyasu , Ohshima Keiichi , Sugiura Teiichi , Ashida Ryo , Ohgi Katsuhisa , Bando Etsuro , Fujiya Keiichi , Shiomi Akio , Kagawa Hiroyasu , Imamura Taisuke , Nakayama Goro , Kodera Yasuhiro , Uesaka Katsuhiko , Ohike Nobuyuki , Norose Tomoko , Sasaki Keiko , Sugino Takashi , Ohnami Sumiko , Nagashima Takeshi , Urakami Kenichi , Akiyama Yasuto , Yamaguchi Ken 
Published: March 2023

AbstractBackgroundSmall intestine carcinoma (SIC) cases in Japan have recently been treated with chemotherapy according to colorectal carcinoma classification, while papilla of Vater carcinoma (PVC) cases according to cholangiocarcinoma (CHC) classification. However, few research reports support the molecular genetic validity of these therapeutic choices.Patients and methodsHere, we investigated the clinicopathological and molecular genetic factors of SIC and PVC. We used the data from the Japanese version of The Cancer Genome Atlas. Additionally, molecular genetic data on gastric adenocarcinoma (GAD), colorectal adenocarcinoma (CRAD), pancreatic ductal adenocarcinoma (PDAC), and CHC were also referred to.ResultsThis study consisted of tumor samples from 12 patients of SIC and three patients of PVC treated from January 2014 to March 2019. Among them, six patients had pancreatic invasion. t‐Distributed stochastic neighbor embedding analysis showed that the gene expression pattern of SIC was similar not only to those of GAD and CRAD, but also to that of PDAC in the pancreatic invasion patients. In addition, PVC resembled the GAD, CRAD, and PDAC, rather than the CHC. The molecular genetic characteristics of the six patients with pancreatic invasion were: one had high microsatellite instability, two had a TP53 driver mutation, and three had tumor mutation burden values <1 mutation/Mb with no driver mutation.ConclusionsIn this study, the extensive gene expression profiling of organ carcinomas newly suggests that SIC or PVC may resemble GAD, CRAD, and PDAC. In addition, the data demonstrate that pancreatic invasive patients may be classified into several subtypes using molecular genetic factors.
Real‐Time Interactive Navigation on Input‐Output Data Sets in Chemical Processes
Authors: Baldan Marco , Ludl Patrick Otto , Süss Philipp , Schack Dominik , Schmidt Robin , Bortz Michael 
Published: March 2023

AbstractInput‐output data sets are ubiquitous in chemical process engineering. We introduce a real‐time interactive navigation framework that provides several capabilities to the decision maker (DM). Once a surrogate model is trained the DM can perform what‐if analyses in both input and output spaces by manipulating sliders. An approximated convex hull spanned in the input space supports both a reliable surrogate prediction and a navigation close to the data set. The framework has been tested on data sets obtained with a flowsheet simulator modeling a real steam methane reforming process.
Highly sensitive single tube B‐lymphoblastic leukemia/lymphoma minimal/measurable residual disease test robust to surface antigen directed therapy
Authors: Gao Qi , Liu Ying , Aypar Umut , Baik Jeeyeon , Londono Dory , Sun Xiaotian , Zhang Jingping , Zhang Yanming , Roshal Mikhail 
Published: March 2023

AbstractBackgroundMeasurement of minimal/measurable residual disease (MRD) in B‐lymphoblastic leukemia/lymphoma (B‐ALL) has become a routine clinical evaluation tool and remains the strongest predictor of treatment outcome. In recent years, new targeted anti‐CD19 and anti‐CD22 antibody‐based and cellular therapies have revolutionized the treatment of the high‐risk B‐ALL. The new treatments raise challenges for diagnostic flow cytometry, which relies on the presence of specific surface antigens to identify the population of interest. So far, reported flow cytometry‐based assays are developed to either achieve a deeper MRD level or to accommodate the loss of surface antigens post‐target therapies, but not both.MethodsWe developed a single tube flow cytometry assay (14‐color‐16‐parameters). The method was validated using 94 clinical samples as well as spike‐in and replicate experiments.ResultsThe assay was well suited for monitoring response to targeted therapies and reached a sensitivity below 10−5 with acceptable precision (coefficient of variation < 20%), accuracy, and interobserver variability (κ = 1).ConclusionsThe assay allows for sensitive disease detection of B‐ALL MRD independent of CD19 and CD22 expression and allows uniform analysis of samples regardless of anti‐CD19 and CD22 therapy.
Clomiphene citrate: A potential alternative for testosterone therapy in hypogonadal males
Authors: Huijben M. , Lock M. T. W. T. , de Kemp V. F. , Beck J. J. H. , De Kort L. M. O. , van Breda H. M. K. 
Published: March 2023

AbstractBackgroundHypogonadism is a worldwide problem among men causing sexual, physical and mental problems. Testosterone therapy is the first‐choice treatment for male hypogonadism, with several side effects, that is, subfertility. Clomiphene citrate (CC) is an alternative off‐label therapy for a certain group of hypogonadal males, especially for those with an active or future child wish. There is scarce literature in usage of CC for men with hypogonadism. The aim of this retrospective study was to evaluate the effectiveness and safety of CC for hypogonadal males.MethodsIn this single‐centre study, men treated with CC for hypogonadism were evaluated retrospectively. Primary outcome was hormonal evaluation including total testosterone (TT), free testosterone (FT), luteinizing hormone (LH) and follicle stimulating hormone (FSH). Secondary outcomes were hypogonadal symptoms, metabolic and lipid parameters, haemoglobin (Hb), haematocrit (Ht), prostate specific antigen (PSA), side effects, the effect of a trial without medication and potential predictors for biochemical and clinical response.ResultsIn total, 153 hypogonadal men were treated with CC. Mean TT, FT, LH and FSH increased during treatment. TT increased from 9 to 16 nmol/L, with a biochemical increase in 89% of the patients. In patients who continued CC treatment, an increased level of TT persisted after 8 years of treatment. With CC treatment, 74% of the patients experienced hypogonadal symptom improvement. LH at the lower normal range before CC treatment was predictive for better TT response. During CC therapy, few side effects were reported and no clinical important changes in PSA, Hb and Ht were found.ConclusionClomiphene citrate is an effective therapy on short and long term, improving both clinical symptoms and biochemical markers of male hypogonadism with few side effects and good safety aspects.
Transforming pharmacy practice in Kuwait
Authors: Al‐Haqan Asmaa , Moreau Pierre , Alghanem Sarah , Shaaban Jenan , Alsalem Adel , Hajjiah Adnan , Abdullah Ali Hadi , Al‐Saleh Batool , Al‐Qadi Eman , Al‐Soraj Monerah , Al‐Bader Abdullah 
Published: March 2023

AbstractIn the last few decades, pharmacy services have expanded to fulfil the need for more complex health needs from population worldwide. Moving from ‘product‐centred’ to a ‘patient‐centred’ profession, pharmacists are required to master more professional competencies to deliver high quality pharmaceutical services to their patients and community. In Kuwait pharmacy practice has long been identified as a sector yet to be developed. With the announcement of the ‘new Kuwait vision 2035’ planning for pharmacy practice and workforce development and improvement has become imperative. Academic, professional, and regulatory bodies have collaborated to shape the future of pharmacy profession in the country. The approach described here reflects the initial steps for transforming and advancing the pharmacy profession in Kuwait.
Copper(II)‐TEMPO Interaction
Authors: Mehara Jaya , Roithová Jana 
Published: March 2023

AbstractCopper(II) complexes with N‐oxyl reactants such as TEMPO can selectively oxidize alcohols to aldehydes or ketones. The proposed copper intermediates of the oxidation reaction were extensively theoretically studied, but they were never experimentally detected. Here, we present an analysis of “frozen” intermediates that contain alcohols without α‐hydrogen atoms, thus preventing oxidation. The copper(II)‐TEMPO complexes with a bipyridine‐type ancillary ligand were isolated by electrospray ionization mass spectrometry and investigated spectroscopically by cryogenic photodissociation spectroscopy. The vibrational characteristics of the complexes suggest that TEMPO retains its unpaired electron even upon coordination with copper(II). In agreement, the electronic photodissociation spectra of the TEMPO‐copper(II) complexes show a characteristic band for gaseous copper(II) complexes. These results contradict interpretations of some previous density functional theory (DFT) analyses of possible reaction intermediates. The experimental data were confronted with theoretical results obtained by pure DFT (OPBE, TPSS) and hybrid DFT (TPSSH, B3LYP) calculations. The methods favor different ground states and capture various aspects of the experimental results demonstrating a multiconfigurational character of the copper(II)‐TEMPO complexes.