bluuebunny/crossref_metadata_2025_split huggingface dataset:
CCDC50 promotes tumor growth through regulation of lysosome homeostasis
Authors: Jia Penghui , Tian Tian , Li Zibo , Wang Yicheng , Lin Yuxin , Zeng Weijie , Ye Yu , He Miao , Ni Xiangrong , Pan Ji'an , Dong Xiaonan , Huang Jian , Li Chun‐mei , Guo Deyin , Hou Panpan 
Published: September 2023

AbstractThe maintenance of lysosome homeostasis is crucial for cell growth. Lysosome‐dependent degradation and metabolism sustain tumor cell survival. Here, we demonstrate that CCDC50 serves as a lysophagy receptor, promoting tumor progression and invasion by controlling lysosomal integrity and renewal. CCDC50 monitors lysosomal damage, recognizes galectin‐3 and K63‐linked polyubiquitination on damaged lysosomes, and specifically targets them for autophagy‐dependent degradation. CCDC50 deficiency causes the accumulation of ruptured lysosomes, impaired autophagic flux, and superfluous reactive oxygen species, consequently leading to cell death and tumor suppression. CCDC50 expression is associated with malignancy, progression to metastasis, and poor overall survival in human melanoma. Targeting CCDC50 suppresses tumor growth and lung metastasis, and enhances the effect of BRAFV600E inhibition. Thus, we demonstrate critical roles of CCDC50‐mediated clearance of damaged lysosomes in supporting tumor growth, hereby identifying a potential therapeutic target of melanoma.
Atrial fibrillation in the elderly and long-livers: a retrospective analysis of the clinical profile of patients using artificial intelligence
Authors: Druzhilov M. A. , Kuznetsova T. Yu. 
Published: September 2023

Aim. Retrospective analysis of the clinical characteristics of elderly patients with atrial fibrillation (AF) and long-livers in individual subjects of the Russian Federation using artificial intelligence.Material and methods. The information was obtained from the Webiomed predictive analytics platform. The main database included 144431 patients with AF who received care in medical organizations in 6 constituent entities of the Russian Federation in the period 2016-2019. Of these, 56830 (39,3%) persons were aged ≥75 years: 47595 aged 75-89 years, 9235 aged ≥90 years.Results. Patients with AF aged ≥75 years compared with persons aged 18-74 years were characterized by a significantly higher incidence of hypertension, type 2 diabetes, estimated glomerular filtration rate <60 ml/min/1,73 m2, heart failure and peripheral atherosclerosis, thromboembolic (TEE), atherothrombotic and hemorrhagic events. The prescription rate of anticoagulant therapy (ACT) was 29,6% and was lower (p<0,001) compared with a subgroup of people with AF aged 1874 years with a high risk of TEE (41,2%). Among patients with AF aged ≥75 years, in 9,4% of cases, no additional (in relation to age and sex) CHA2DS2-VASc points were found, and in 1/3 of individuals there was only one additional points. With an increase CHA2DS2-VASc score in these patients, the ACT prescription rate increased from 13 to 55,5%. The prescription rate of acetylsalicylic acid was 12,8%. Only 33% of people with AF aged ≥75 years who had an ischemic stroke were prescribed ACT.Conclusion. The retrospective analysis indicates a high proportion of people aged ≥75 years in the structure of all patients with AF. This group is characterized by a significant comorbidity, a high TEE risk, hemorrhagic and atherothrombotic events. At the same time, the ACT prescription rate as of 2016-2019 in individual subjects of the Russian Federation did not meet the requirements of the clinical guidelines.
Monitoring of Local Earthquakes in Haiti Using Low-Cost, Citizen-Hosted Seismometers and Regional Broadband Stations
Authors: Paul Sylvert , Monfret Tony , Courboulex Françoise , Chèze Jérôme , Calais Eric , Julien Symithe Steeve , Deschamps Anne , Peix Fabrice , Ambrois David , Martin Xavier , St Fleur Sadrac , Boisson Dominique 
Published: September 2023

Abstract
Seismic monitoring in Haiti is currently provided by a mixed network of low-cost Raspberry Shake (RS) seismic stations hosted by citizens, and short-period and broadband stations located mainly in neighboring countries. The level of earthquake detection is constantly improving for a better spatio-temporal distribution of seismicity as the number of RS increases. In this article, we analyze the impact of the quality of the signals recorded by the RS—low-cost seismometers with the smallest magnitude that the network can detect by studying the ambient noise level at these stations. Because the RS stations are installed as part of a citizen-science project, their ambient noise estimated by the power spectral density (PSD) method often shows a high-noise level at frequencies above 1 Hz. In the near field (&lt;50 km), we show that the network detects seismic events of local magnitude on the order of 2.2 with signal-to-noise ratios (SNRs) greater than 4. Improving the network detection threshold requires densifying the network with more RS stations in locations that are less noisy, if possible. In spite of these limitations, this mixed network has provided near-field data essential to rapidly understand the mechanism of the mainshock of the 14 August 2021 Mw 7.2 earthquake, to monitor its sequence of aftershocks in near-real time, and to monitor background seismicity in Haiti on a routine basis.
Epidemiology Study of Brucellosis in Polewali Mandar District, Indonesia
Authors: Amaliah Fitri , Sumiarto Bambang , Nugroho Widagdo Sri , Untari Tri , Hartawan Dinar Hadi Wahyu , Agustia Agustia 
Published: September 2023

<p>This research aims to determine the prevalence rate of brucellosis in the Polman District, examine the risk factors associated with seropositive diagnoses of brucellosis, and also to determine the brucellosis case model at the farm level. This research was carried out through a cross-sectional study and obtained a sample size of 395 serum. Samples were tested<em> </em>through the RBT and CFT. Identification of risk factors is based on questionnaire data conducted on around 113 breeders spread across Polman Regency. The data were analyzed using univariate and bivariate descriptive statistics, chi-square, and odds ratio (OR). The brucellosis model at the farm level was analyzed by multivariate logistic regression. The results of this study indicate the prevalence of brucellosis in Polman Regency is 27.1%. Risk factors associated with diagnosis of brucellosis in Polman Regency included the history of abortion (p=0.000; OR=128), handling of aborted animal (p=0.000; OR=94.667), abortion at the end of pregnancy (p=0.000; OR=62.333), knowledge about brucellosis (p=0.000; OR=9.841), handling of residual abortions (p=0.003; OR=8,471), high grazing density (p=0.000; OR=6.861), introduction of new livestock (p=0.006; OR=5.833), dirty cage (p=0.003; OR=3.600), and grazing method (p=0.005; OR=3.167). Models of diagnosis brucellosis in Polman Regency is = -2,48923 + 3,38734 history of abortion + 2,06312 abortions at the end of pregnancy. The model shows that the history of abortion (β=+3.387; OR=29.588) and the incidence of abortion at the end of pregnancy (β=+2.205; OR = 7.871) can increase the seropositive diagnosis of brucellosis at the farm level<em>.</em></p>
EFFECT OF ALUMINIUM STRESS ON GERMINATION, GROWTH AND PHOTOSYNTHETIC PIGMENTS OF Amaranthus hybridus
Authors: David Musyimi Mutisya 
Published: September 2023

<p align="justify"><em>Amaranthus hybridus </em>is widely distributed and used as a food plant in many parts of the world. Aluminium toxicity in the soil is one environmental stress that limits crop growth and production in acid soils. However, the level of aluminium stress tolerance depends on the plant species or genotype. A study was conducted at Maseno University, Kenya on the effects of aluminium stress on germination, growth and leaf photosynthetic pigments of <em>Amaranthus hybridus </em>seedlings. Ten uniform seeds of <em>Amaranthus hybridus </em>weretreated in sodium hypochlorite solution and were placed on dried petri dishes lined with Whatsman No. 1 filter papers. Filter papers were then moistened with 5ml of nutrient solution containing either 0 mM (distilled water) or (2, 4, 6, 8 and 10 mM) (Al toxicity) AlCl<sub>3</sub>·6H<sub>2</sub>O replicated three times. The germination was assessed for five days to ascertain the number of seeds that germinated over time. Five litre pots were filled with top soil from Maseno University’s garden. Five seeds of <em>Amaranthus hybridus </em>were sown in each of the pots and were irrigated every day with 250 ml of tap water per pot for two weeks. After two weeks the seedlings were thinned to 2 plants per pot and treatments initiated. Seedlings were irrigated daily with nutrient solution containing 0 mM (control – tap water) or (2, 4, 6, 8 and 10 mM) (Al toxicity) AlCl<sub>3</sub>·6H<sub>2</sub>O in triplicates arranged in a completely randomized design in a green house. Data on shoot height, leaf area and number of leaves, shoot and root fresh and dry weights, chlorophyll <em>a</em>, chlrophyl <em>b</em>, total chlorophyll and carotenoid contents were determined at the end of the experiment. Data collected was subjected to analysis of variance (ANOVA) and treatment means separated and compared using Least Significance Difference (LSD). Germination percentage of <em>Amaranthus hybridus</em> was significantly reduced by the aluminiumsolution stress as compared to control treatment. Growth and photosynthetic pigments parameters were significantly reduced by the aluminium stress.The results of this study have clearly shown that <em>Amaranthus hybridus </em>speciesis very sensitive to aluminium toxicity.</p>
Prevalence of and Factors Associated With Tobacco Dependence Among Adolescents Aged 12–16 Years Who Were Currently Smoking Tobacco in 125 Countries or Territories, 2012–2019
Authors: Yang Hui , Ma Chuanwei , Zhao Min , Xi Bo 
Published: September 2023

Objectives. To examine the global prevalence of and factors associated with tobacco dependence among adolescents who are currently smoking. Methods. We obtained 2012 to 2019 Global Youth Tobacco Survey data on 67 406 adolescents aged 12 to 16 years from 125 countries or territories (hereafter countries). Those with tobacco dependence were defined as current smokers who felt a strong desire to smoke again within 24 hours after smoking or who had ever smoked or felt like smoking first thing in the morning. Results. The global prevalence of tobacco dependence among adolescents who were currently smoking was 38.4% (95% confidence interval [CI] = 34.0, 42.7). The prevalence was highest in high-income countries (49.8%; 95% CI = 47.0, 52.6) and lowest in lower-middle-income countries (31.2%; 95% CI = 26.9, 35.4). Secondhand smoke exposure, parental smoking, smoking among closest friends, tobacco advertisement exposure, and offers of free tobacco products were positively associated with tobacco dependence. Conclusions. Nearly 40% of adolescents who are currently smoking have tobacco dependence worldwide. Public Health Implications. Our findings emphasize the need to develop tobacco control interventions to prevent experimentation from progressing to regular smoking among adolescents who are currently smoking tobacco. (Am J Public Health. 2023;113(8):861–869. https://doi.org/10.2105/AJPH.2023.307283 )
State Policy Removing the Personal Belief Exemption for Measles, Mumps, and Rubella (MMR) School Immunization Requirement, Washington State, 2014–2022
Authors: Moore Tyler P. , Bennett Julia C. , Graff Katherine , Rao Mayuree , Augusto Orvalho , Chu Helen Y. , Wagenaar Bradley H. , Bell Teal R. 
Published: September 2023

Objectives. To assess the impact of Washington State’s 2019 Engrossed House Bill (EHB) 1638—which removed measles, mumps, and rubella (MMR) personal belief exemptions—on MMR vaccine series completion and exemption rates in K–12 students. Methods. We used interrupted time-series analyses to examine changes in MMR vaccine series completion rates before and after EHB 1638 was passed and the χ2 test for differences in exemption rates. Results. EHB 1638 implementation was associated with a 5.4% relative increase in kindergarten MMR vaccine series completion rates (95% confidence interval = 3.8%, 7.1%; P ≤ .001), and results were similar with Oregon as a control state (no change observed in Oregon; P = .68). MMR exemptions overall decreased 41% (from 3.1% in 2018–2019 to 1.8% in 2019–2020; P ≤ .001), and religious exemptions increased 367% (from 0.3% to 1.4%; P ≤ .001). Conclusions. EHB 1638 was associated with an increase in MMR vaccine series completion rates and a decrease in any MMR exemption. However, effects were partially offset by an increase in religious exemption rates. Public Health Implications. Removal of personal belief exemptions for the MMR immunization requirement only may be an effective approach to increase MMR vaccine coverage rates statewide and among underimmunized communities. (Am J Public Health. 2023;113(7):795–804. https://doi.org/10.2105/AJPH.2023.307285 )
Social Vulnerability in US Communities Affected by Wildfire Smoke, 2011 to 2021
Authors: Vargo Jason , Lappe Brooke , Mirabelli Maria C. , Conlon Kathryn C. 
Published: September 2023

Objectives. To describe demographic and social characteristics of US communities exposed to wildfire smoke. Methods. Using satellite-collected data on wildfire smoke with the locations of population centers in the coterminous United States, we identified communities potentially exposed to light-, medium-, and heavy-density smoke plumes for each day from 2011 to 2021. We linked days of exposure to smoke in each category of smoke plume density with 2010 US Census data and community characteristics from the Centers for Disease Control and Prevention’s Social Vulnerability Index to describe the co-occurrence of smoke exposure and social disadvantage. Results. During the 2011-to-2021 study period, increases in the number of days of heavy smoke were observed in communities representing 87.3% of the US population, with notably large increases in communities characterized by racial or ethnic minority status, limited English proficiency, lower educational attainment, and crowded housing conditions. Conclusions. From 2011 to 2021, wildfire smoke exposures in the United States increased. As smoke exposure becomes more frequent and intense, interventions that address communities with social disadvantages might maximize their public health impact. (Am J Public Health. 2023;113(7):759–767. https://doi.org/10.2105/AJPH.2023.307286 )
Spatiotemporal Analysis Exploring the Effect of Law Enforcement Drug Market Disruptions on Overdose, Indianapolis, Indiana, 2020–2021
Authors: Ray Bradley , Korzeniewski Steven J. , Mohler George , Carroll Jennifer J. , del Pozo Brandon , Victor Grant , Huynh Philip , Hedden Bethany J. 
Published: September 2023

Objectives. To test the hypothesis that law enforcement efforts to disrupt local drug markets by seizing opioids or stimulants are associated with increased spatiotemporal clustering of overdose events in the surrounding geographic area. Methods. We performed a retrospective (January 1, 2020 to December 31, 2021), population-based cohort study using administrative data from Marion County, Indiana. We compared frequency and characteristics of drug (i.e., opioids and stimulants) seizures with changes in fatal overdose, emergency medical services nonfatal overdose calls for service, and naloxone administration in the geographic area and time following the seizures. Results. Within 7, 14, and 21 days, opioid-related law enforcement drug seizures were significantly associated with increased spatiotemporal clustering of overdoses within radii of 100, 250, and 500 meters. For example, the observed number of fatal overdoses was two-fold higher than expected under the null distribution within 7 days and 500 meters following opioid-related seizures. To a lesser extent, stimulant-related drug seizures were associated with increased spatiotemporal clustering overdose. Conclusions. Supply-side enforcement interventions and drug policies should be further explored to determine whether they exacerbate an ongoing overdose epidemic and negatively affect the nation’s life expectancy. (Am J Public Health. 2023;113(7):750–758. https://doi.org/10.2105/AJPH.2023.307291 )
Evaluation of Public Health Contact Tracing for Mpox Among Gay, Bisexual, and Other Men Who Have Sex With Men—10 US Jurisdictions, May 17–July 31, 2022
Authors: Cope Anna Barry , Kirkcaldy Robert D. , Weidle Paul J. , Jackson David A. , Laramee Nicholas , Weber Robyn , Rowse Julia , Mangla Anil , Fox Brian , Saunders Katharine E. , Taniguchi Kristen , Usagawa Lauren , Cahill Megan E. , Harrington Pauline , Ricketts Erin K. , Harbi Khalil , Malec Lenka , Templin Tingting Gu , Drociuk Dan , Hannibal Terri , Klos Rachel , Bernstein Kyle T. 
Published: September 2023

Objectives. To examine the potential impact of contact tracing to identify contacts and prevent mpox transmission among gay, bisexual, and other men who have sex with men (MSM) as the outbreak expanded. Methods. We assessed contact tracing outcomes from 10 US jurisdictions before and after access to the mpox vaccine was expanded from postexposure prophylaxis for persons with known exposure to include persons at high risk for acquisition (May 17–June 30, 2022, and July 1–31, 2022, respectively). Results. Overall, 1986 mpox cases were reported in MSM from included jurisdictions (240 before expanded vaccine access; 1746 after expanded vaccine access). Most MSM with mpox were interviewed (95.0% before vaccine expansion and 97.0% after vaccine expansion); the proportion who named at least 1 contact decreased during the 2 time periods (74.6% to 38.9%). Conclusions. During the period when mpox cases among MSM increased and vaccine access expanded, contact tracing became less efficient at identifying exposed contacts. Public Health Implications. Contact tracing was more effective at identifying persons exposed to mpox in MSM sexual and social networks when case numbers were low, and it could be used to facilitate vaccine access. (Am J Public Health. 2023;113(7):815–818. https://doi.org/10.2105/AJPH.2023.307301 )
The Pent-Up Demand for Breastfeeding Among US Women: Trends After COVID-19 Shelter-in-Place
Authors: Hamad Rita , Collin Daniel F. , Gemmill Alison , Jackson Kaitlyn , Karasek Deborah 
Published: September 2023

Objectives. To estimate changes in national breastfeeding trends immediately before and after COVID-19‒related workplace closures in early 2020. Methods. The implementation of shelter-in-place policies in early 2020, when 90% of people in the United States were urged to remain at home, represents a unique natural experiment to assess the pent-up demand for breastfeeding among US women that may be stymied by the lack of a national paid leave policy. We used the 2017–2020 Pregnancy Risk Assessment Monitoring System (n = 118 139) to estimate changes in breastfeeding practices for births occurring before and after shelter-in-place policies were implemented in the United States. We did this in the overall sample and by racial/ethnic and income subgroups. Results. There was no change in breastfeeding initiation and a 17.5% increase in breastfeeding duration after shelter-in-place, with lingering effects through late 2020. High-income and White women demonstrated the largest gains. Conclusions. The United States ranks worse than similar countries when it comes to breastfeeding initiation and duration. This study suggests that this is partly attributable to inadequate access to postpartum paid leave. This study also demonstrates inequities introduced by patterns of remote work during the pandemic. (Am J Public Health. 2023;113(8):870–873. https://doi.org/10.2105/AJPH.2023.307313 )
COVID-19 Infections, Pandemic-Related Social and Economic Impacts, and Changes to Mental and Self-Rated Health Among Latinx Immigrant Housecleaners in New York City: The Safe and Just Cleaners Study
Authors: Baron Sherry , Cuervo Isabel , Shah Dhwanil , Gonzalez Ana , Harari Homero , Flores Deysi 
Published: September 2023

Objectives. To estimate impacts of COVID-19 infections and social and economic sequelae on mental and self-rated health among Latinx immigrant housecleaners in New York City. Methods. From March to June 2021, we conducted a follow-up study with 74% retention of 402 housecleaners initially surveyed before the pandemic between August 2019 and February 2020. We measured rates of self-reported COVID-19 infections, COVID-19 antibodies, and pandemic-related social and economic sequelae and examined predictors of mental and self-rated health changes using logistic regression models. Results. Fifty-three percent reported COVID-19 infections, consistent with the rate demonstrating COVID-19 antibodies. During shutdown of nonessential services, from March 22 to June 8, 2020, 29% worked as housecleaners, although this was not associated with higher COVID-19 infection rates. COVID-19–related stigma at work, lost earnings owing to COVID-19 infections, housing insecurity, food insecurity, and unsafe homes, including experiencing intimate partner verbal abuse, were statistically associated with changes in mental or self-rated health compared with prepandemic measures. Conclusions. The disproportionate impact and virtually nonexistent safety net housecleaners experienced during the first year of the pandemic highlight the importance of inclusive stopgap measures to mitigate economic insecurity and its sequelae. (Am J Public Health. 2023;113(8):893–903. https://doi.org/10.2105/AJPH.2023.307324 )
Promising Practices Observed in High-Throughput COVID-19 Vaccination Sites in the United States, February–May 2021
Authors: McColloch Caitlin E. , Samson Marsha E. , Parris KaeAnne , Stewart Amy , Robinson Judith A. , Cooper Barbara , Galloway Eboni , Garcia Robert , Gilani Zunera , Jayapaul-Philip Bina , Lucas Paul , Nguyen Kimberly H. , Noe Rebecca S. , Trudeau Aimée-Rika T. , Kennedy Erin D. 
Published: September 2023

Objectives. To identify promising practices for implementing COVID-19 vaccination sites. Methods. The Centers for Disease Control and Prevention (CDC) and Federal Emergency Management Agency (FEMA) assessed high-throughput COVID-19 vaccination sites across the United States, including Puerto Rico, after COVID-19 vaccinations began. Site assessors conducted site observations and interviews with site staff. Qualitative data were compiled and thematically analyzed. Results. CDC and FEMA conducted 134 assessments of high-throughput vaccination sites in 25 states and Puerto Rico from February 12 to May 28, 2021. Promising practices were identified across facility, clinical, and cross-cutting operational areas and related to 6 main themes: addressing health equity, leveraging partnerships, optimizing site design and flow, communicating through visual cues, using quick response codes, and prioritizing risk management and quality control. Conclusions. These practices might help planning and implementation of future vaccination operations for COVID-19, influenza, and other vaccine-preventable diseases. Public Health Implications. These practices can be considered by vaccination planners and providers to strengthen their vaccination site plans and implementation of future high-throughput vaccination sites. (Am J Public Health. 2023;113(8):909–918. https://doi.org/10.2105/AJPH.2023.307331 )