bluuebunny/crossref_metadata_2025_split huggingface dataset:
The roles and challenges of the primary health care systems in epidemic management: a scoping review
Authors: Shami Elham , Gholipour Kamal , Naghibi Deniz , Azami-Aghdash Saber 
Published: September 2023

Abstract

Background and aim:
During the early stage of pandemics, primary health care (PHC) is the first point of contact with the health system for people. This study aimed to find the leading roles and challenges of the PHC system in dealing with the outbreak of infectious diseases

Methods:
The current scoping review was conducted in 2022 using the Arkesy and O’Malley framework. A bibliographic search was conducted in PubMed, Web of Science, and Scopus databases. Following a Google Scholar search, a manual search in some journals, reference checks for articles, and a review of organizational reports, websites, and other sources of information were also conducted. Data were analyzed using the content-analysis method.

Findings:
Finally, 65 documents (42 articles and 23 reports, books, and news) were included in the study. Initially, 626 codes were extracted, and 132 final codes were categorized into eight main themes and 44 sub-themes. The main themes for the roles of PHC included: service provision, education and knowledge, surveillance, access, coordination and communication, management and leadership, infrastructure change and rapid preparation, and patient and community management. Regarding the challenges faced by PHC in the epidemic of infectious diseases, 24 key challenges were identified and categorized into four major areas.

Conclusions:
Based on the results of the present study, there is a need for further studies to formulate and theorize the specific roles of PHC in managing infectious disease epidemics. The results of this study can be utilized by researchers and officials to inform their efforts in addressing this purpose.
Ultra-Wideband Six-Port Network Miniaturization—Matching
Authors: Empliouk Tzichat M. , Bantavis Petros I. , Koltsidas Christos I. , Kaifas Theodoros N. F. , Kyriacou George A. 
Published: September 2023

AbstractIn this paper, a new design approach for the six-port (SP) junction is introduced. The proposed design includes a generalized broadband matching and smooth miniaturization scheme and is extendable for any passive multiport structure. A multilayer technology and a microstrip to slot coupling operation are employed for the designed SP, which comprises power divider and three hybrid couplers. The conducted measurements of the constructed SP junctions validates the design approach. Optimal performance of the SP network in terms of miniaturization, bandwidth, and response accuracy were obtained for the 5G low band.
A 10-Year Observational Study on Twin Pregnancy: Role of Fetal Sex Pairing on Obstetric Outcome
Authors: Vannuccini Silvia , Bolzonella Sara , Colucci Chiara , Nicchi Costanza , Strambi Noemi , Di Tommaso Mariarosaria 
Published: September 2023

AbstractFetal sex contributes to the determination of obstetric outcome, as pregnancies carrying male babies seem to have an increased risk of maternal-fetal complications. Most studies have been conducted on singleton pregnancies, whereas less evidence is available for twins. A 10-year retrospective observational study was conducted on a cohort of 1180 women with twin pregnancy delivered at a single tertiary hospital. Clinical data on maternal characteristics, and obstetric and neonatal outcomes were collected, and the analysis was performed on monochorionic (MC) and dichorionic (DC) diamniotic twins separately. The group of DC twins included 837 cases, and those conceived by assisted reproductive technologies (ART) were more likely to have one or both female fetuses rather than males. The incidence of hypertensive disorders of pregnancy (HDP) was higher in same-sex pairs than in opposite-sex pairs. No differences were found regarding other obstetric and neonatal outcomes among the three sex-pairing groups. The MC twins group included 228 cases, and in female-carrying pregnancies a higher incidence of gestational diabetes (GDM) was observed compared to the male group. Furthermore, male pairs had significantly lower Apgar scores than females. Fetal sex seems to have a mild effect in twins compared to singleton pregnancies, suggesting a more complex set of factors contributing to pregnancy outcome in multiple pregnancies. However, we observed a higher incidence of HDP among same-sex DC pairs, a higher rate of GDM among MC female-female pairs, and a worse adaptation to extrauterine life among male-male pairs in MC twins.
Non‐Triggering and Then Triggering of a Repeating Aftershock Sequence in the Dead Sea by the 2023 Kahramanmaraş Earthquake Pair: Implications for the Physics of Remote Delayed Aftershocks
Authors: Inbal A. , Ziv A. , Lior I. , Nof R. N. , Eisermann A. S. 
Published: September 2023

AbstractMost aftershocks occur in areas experiencing large co‐seismic stress changes, yet some occur long after the mainshock in remote lightly stressed regions. The triggering mechanism of these remote delayed aftershocks is not well understood. Here, we study aftershocks occurring in the Dead Sea (DS) area following the 2023 Mw7.8 and Mw7.6 Kahramanmaraş earthquakes. Most aftershocks cluster along previously quiescent structures off‐ the main DS fault strand. Visual inspection disclosed three aftershocks instantaneously triggered by the Mw7.6 in the northern DS basin, and match‐filtering revealed a delayed aftershock. Waveform similarity and temporal clustering suggest the northern DS aftershocks re‐rupture a stick‐slip patch loaded by surrounding creep. Velocity‐gradient seismograms show the Mw7.6 exerted larger transient stresses than the Mw7.8, which may explain triggering by the Mw7.6, but not by the Mw7.8. This account of instantaneously triggered repeaters underscores the role of interactions between aseismic and seismic slip in remote triggering.
Calibrating Non‐Thermal Effects on Planktic Foraminiferal Mg/Ca for Application Across the Cenozoic
Authors: Haynes Laura L. , Hönisch Bärbel , Holland Kate , Eggins Stephen , Rosenthal Yair 
Published: September 2023

AbstractForaminiferal Mg/Ca has proven to be a powerful paleothermometer for reconstructing past sea‐surface temperature, which, among other applications, is a critical parameter for boron isotope reconstructions of past surface ocean pH and PCO2. However, recent laboratory culture studies indicate seawater pH and the total dissolved inorganic carbon content (DIC) may both exert a significant additional control on foraminiferal Mg/Ca, likely influencing paleotemperature records as a result of seawater chemistry evolution on geologic timescales. In addition, the seawater Mg/Ca composition (Mg/Casw) has been shown to reduce the sensitivity of foraminiferal Mg/Ca to temperature and possibly its sensitivity to the carbonate system as well. Here we present new Mg/Ca data from laboratory culture experiments with living planktic foraminifera— Globigerinoides ruber (p), Trilobatus sacculifer, and Orbulina universa— grown under a range of different pH and/or seawater DIC conditions and in low Mg/Casw to mimic the chemical composition of the Paleocene ocean. We also conducted targeted [Ca] experiments to help define Mg/Cacalcite–Mg/Casw relationships for each species and conducted new pH experiments with G. bulloides. We find that pH effects on foraminiferal Mg/Ca are reduced or absent at Mg/Casw = 1.5 mol/mol in all three species, and that T. sacculifer is generally insensitive to variable DIC and pH, making it the ideal species for Mg/Ca SST reconstructions back to 20 Ma. We apply our new T. sacculifer calibration to a Middle Miocene Mg/Ca record and provide recommendations for interpreting Mg/Ca records from extinct species.
Emotions behind a mask: the value of disgust
Authors: Pavlova Marina A. , Moosavi Jonas , Carbon Claus-Christian , Fallgatter Andreas J. , Sokolov Alexander N. 
Published: September 2023

AbstractThe impact of face masks on social cognition and interaction became a popular topic due to the long-lasting COVID-19 pandemic. This theme persists in the focus of attention beyond the pandemic, since face covering not only reduces the overall amount of face information available but also introduces biases and prejudices affecting social perception at large. Many questions are still open. One of them is whether gender of beholders affects inferring of emotions covered by face masks. Reading covered faces may be particularly challenging for individuals with mental disorders, most of which are gender-specific. Previous findings are not only sparse, but inconclusive because most research had been conducted online with resulting samples heavily dominated by females. Here in a face-to-face study, females and males were presented with a randomized set of faces covered by masks. In a two-alternative forced-choice paradigm, participants had to indicate facial emotions displayed by posers. In general, the outcome dovetails with earlier findings that face masks affect emotion recognition in a dissimilar way: Inferring some emotions suffers more severely than others, with the most pronounced influence of mask wearing on disgust and close to ceiling recognition of fear and neutral expressions. Contrary to our expectations, however, males were on overall more proficient in emotion recognition. In particular, males substantially excelled in inferring disgust. The findings help to understand gender differences in recognition of disgust, the forgotten emotion of psychiatry, that is of substantial value for a wide range of mental disorders including schizophrenia. Watch Prof. Marina Pavlova discussing this her work and this article: https://vimeo.com/860126397/5966610f49?share=copy.
Reliability of vegetation resilience estimates depends on biomass density
Authors: Smith Taylor , Boers Niklas 
Published: September 2023

AbstractConcerns have been raised that the resilience of vegetated ecosystems may be negatively impacted by ongoing anthropogenic climate and land-use change at the global scale. Several recent studies present global vegetation resilience trends based on satellite data using diverse methodological set-ups. Here, upon a systematic comparison of data sets, spatial and temporal pre-processing, and resilience estimation methods, we propose a methodology that avoids different biases present in previous results. Nevertheless, we find that resilience estimation using optical satellite vegetation data is broadly problematic in dense tropical and high-latitude boreal forests, regardless of the vegetation index chosen. However, for wide parts of the mid-latitudes—especially with low biomass density—resilience can be reliably estimated using several optical vegetation indices. We infer a spatially consistent global pattern of resilience gain and loss across vegetation indices, with more regions facing declining resilience, especially in Africa, Australia and central Asia.
Amivantamab plus lazertinib in osimertinib-relapsed EGFR-mutant advanced non-small cell lung cancer: a phase 1 trial
Authors: Cho Byoung Chul , Kim Dong-Wan , Spira Alexander I. , Gomez Jorge E. , Haura Eric B. , Kim Sang-We , Sanborn Rachel E. , Cho Eun Kyung , Lee Ki Hyeong , Minchom Anna , Lee Jong-Seok , Han Ji-Youn , Nagasaka Misako , Sabari Joshua K. , Ou Sai-Hong Ignatius , Lorenzini Patricia , Bauml Joshua M. , Curtin Joshua C. , Roshak Amy , Gao Grace , Xie John , Thayu Meena , Knoblauch Roland E. , Park Keunchil 
Published: September 2023

AbstractPatients with epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer (NSCLC) often develop resistance to current standard third-generation EGFR tyrosine kinase inhibitors (TKIs); no targeted treatments are approved in the osimertinib-relapsed setting. In this open-label, dose-escalation and dose-expansion phase 1 trial, the potential for improved anti-tumor activity by combining amivantamab, an EGFR-MET bispecific antibody, with lazertinib, a third-generation EGFR TKI, was evaluated in patients with EGFR-mutant NSCLC whose disease progressed on third-generation TKI monotherapy but were chemotherapy naive (CHRYSALIS cohort E). In the dose-escalation phase, the recommended phase 2 combination dose was established; in the dose-expansion phase, the primary endpoints were safety and overall response rate, and key secondary endpoints included progression-free survival and overall survival. The safety profile of amivantamab and lazertinib was generally consistent with previous experience of each agent alone, with 4% experiencing grade ≥3 events; no new safety signals were identified. In an exploratory cohort of 45 patients who were enrolled without biomarker selection, the primary endpoint of investigator-assessed overall response rate was 36% (95% confidence interval, 22–51). The median duration of response was 9.6 months, and the median progression-free survival was 4.9 months. Next-generation sequencing and immunohistochemistry analyses identified high EGFR and/or MET expression as potential predictive biomarkers of response, which will need to be validated with prospective assessment. ClinicalTrials.gov identifier: NCT02609776.
Safety and environmental impact control of cross passage construction in soft soil strata using tunnel boring machine method
Authors: Yunkang Ma , Wei Yan , Yanjie Song , Meiqin Zhang , Sheng Zhou , Tianfang Xiong , Jia Geng , Xiaofan Li , Xuesong Cheng 
Published: September 2023

AbstractThe construction of cross passages using the tunnel boring machine (TBM) method represents an emerging construction technique with numerous advantages. However, owing to the scarcity of application instances, the safety control methodologies and the regulatory patterns concerning environmental impacts remain inconclusive. In this study, a cross passage excavated using the TBM method—the first of its kind in the Tianjin area—was investigated. We identified the key risk control measures for the construction and analysed the TBM operating parameters, monitored ground and building settlements, and monitored mainline tunnel deformations and mechanical responses, revealing the ground and tunnel structure deformation patterns. The following conclusions are drawn. (1) The ground surrounding the cross-passage break-out opening was stabilised by performing secondary grouting and small-range freezing, and the break-in opening was excavated using a completely enclosed steel sleeve. These measures prevented water and sand inflows during the excavation of the break-out and break-in openings in the silt and silty sand strata. (2) The torsional moment of the cutter disc was large during the break-out phase. Break-out mainline tunnel displacement monitoring data indicated that the thrust had a significant effect on the mainline tunnel during the break-out phase. (3) The TBM tunnelling caused ground loss. The ground settlement exhibited a U-shaped distribution along the cross-passage axis, with the maximum settlement being 10 mm. (4) During the break-out phase, the deformation of the break-out mainline tunnel exhibited a duck-egg-shaped distribution. The clearance convergence of the break-out mainline tunnel was within ± 4, and the clearance convergence of the break-in mainline tunnel was controlled within ± 1 mm.
Three-input logic gate based on DNA strand displacement reaction
Authors: Jingjing M. A. 
Published: September 2023

AbstractIn this paper, three kinds of three-input logic gates are designed based on DNA strand displacement reaction, which are three-input OR logic gate, three-input AND logic gate, and three-input MAJORITY logic gate. The logic gates designed in this paper takes different DNA strands as input and fluorescence signals as output. The biochemical experimental results verify my designs. The results show that DNA strand displacement technology has important application value in DNA computing, especially in the construction of DNA molecular logic gates.
Neutrophil extracellular trap formation during surgical procedures: a pilot study
Authors: Huang Melody Ying-Yu , Lippuner Christoph , Schiff Marcel , Book Malte , Stueber Frank 
Published: September 2023

AbstractNeutrophils can release neutrophil extracellular traps (NETs) containing DNA fibres and antimicrobial peptides to immobilize invading pathogens. NET formation (NETosis) plays a vital role in inflammation and immune responses. In this study we investigated the impact of surgical trauma on NETosis of neutrophils. Nine patients undergoing “Transcatheter/percutaneous aortic valve implantation” (TAVI/PAVI, mild surgical trauma), and ten undergoing “Aortocoronary bypass” (ACB, severe surgical trauma) were included in our pilot study. Peripheral blood was collected before, end of, and after surgery (24 h and 48 h). Neutrophilic granulocytes were isolated and stimulated in vitro with Phorbol-12-myristate-13-acetate (PMA). NETosis rate was examined by microscopy. In addition, HLA-DR surface expression on circulating monocytes was analysed by flow-cytometry as a prognostic marker of the immune status. Both surgical procedures led to significant down regulation of monocytic HLA-DR surface expression, albeit more pronounced in ACB patients, and there was a similar trend in NETosis regulation over the surgical 24H course. Upon PMA stimulation, no significant difference in NETosis was observed over time in TAVI/PAVI group; however, a decreasing NETosis trend with a significant drop upon ACB surgery was evident. The reduced PMA-induced NETosis in ACB group suggests that the inducibility of neutrophils to form NETs following severe surgical trauma may be compromised. Moreover, the decreased monocytic HLA-DR expression suggests a post-operative immunosuppressed status in all patients, with a bigger impact by ACB, which might be attributed to the extracorporeal circulation or tissue damage occurring during surgery.
Ocean-forcing of cool season precipitation drives ongoing and future decadal drought in southwestern North America
Authors: Seager Richard , Ting Mingfang , Alexander Patrick , Liu Haibo , Nakamura Jennifer , Li Cuihua , Newman Matthew 
Published: September 2023

AbstractThe US Southwest is in a drought crisis that has been developing over the past two decades, contributing to marked increases in burned forest areas and unprecedented efforts to reduce water consumption. Climate change has contributed to this ongoing decadal drought via warming that has increased evaporative demand and reduced snowpack and streamflows. However, on the supply side, precipitation has been low during the 21st century. Here, using simulations with an atmosphere model forced by imposed sea surface temperatures, we show that the 21st century shift to cooler tropical Pacific sea surface temperatures forced a decline in cool season precipitation that in turn drove a decline in spring to summer soil moisture in the southwest. We then project the near-term future out to 2040, accounting for plausible and realistic natural decadal variability of the Pacific and Atlantic Oceans and radiatively-forced change. The future evolution of decadal variability in the Pacific and Atlantic will strongly influence how wet or dry the southwest is in coming decades as a result of the influence on cool season precipitation. The worst-case scenario involves a continued cold state of the tropical Pacific and the development of a warm state of the Atlantic while the best case scenario would be a transition to a warm state of the tropical Pacific and the development of a cold state of the Atlantic. Radiatively-forced cool season precipitation reduction is strongest if future forced SST change continues the observed pattern of no warming in the equatorial Pacific cold tongue. Although this is a weaker influence on summer soil moisture than natural decadal variability, no combination of natural decadal variability and forced change ensures a return to winter precipitation or summer soil moisture levels as high as those in the final two decades of the 20th century.
Coinfection with chytrid genotypes drives divergent infection dynamics reflecting regional distribution patterns
Authors: Carvalho Tamilie , Medina Daniel , P. Ribeiro Luisa , Rodriguez David , Jenkinson Thomas S. , Becker C. Guilherme , Toledo Luís Felipe , Hite Jessica L. 
Published: September 2023

AbstractBy altering the abundance, diversity, and distribution of species—and their pathogens—globalization may inadvertently select for more virulent pathogens. In Brazil’s Atlantic Forest, a hotspot of amphibian biodiversity, the global amphibian trade has facilitated the co-occurrence of previously isolated enzootic and panzootic lineages of the pathogenic amphibian-chytrid (Batrachochytrium dendrobatidis, ‘Bd’) and generated new virulent recombinant genotypes (‘hybrids’). Epidemiological data indicate that amphibian declines are most severe in hybrid zones, suggesting that coinfections are causing more severe infections or selecting for higher virulence. We investigated how coinfections involving these genotypes shapes virulence and transmission. Overall, coinfection favored the more virulent and competitively superior panzootic genotype, despite dampening its transmission potential andoverallvirulence. However, for the least virulent and least competitive genotype, coinfection increased bothoverallvirulence and transmission. Thus, by integrating experimental and epidemiological data, our results provide mechanistic insight into how globalization can select for, and propel, the emergence of introduced hypervirulent lineages, such as the globally distributed panzootic lineage of Bd.
Interleukin-17D produced by alveolar epithelial type II cells alleviates LPS-induced acute lung injury via the Nrf2 pathway
Authors: Dong Shuan , Liu Shasha , Gao Qiaoying , Shi Jia , Song Kai , Wu Ya , Liu Huayang , Guo Chenxu , Huang Yan , Du Shihan , Li Xiangyun , Ge Lixiu , Yu Jianbo 
Published: September 2023

Abstract
Background: Sepsis engenders an imbalance in the body’s inflammatory response, with cytokines assuming a pivotal role in its progression. A relatively recent addition to the interleukin-17 family, denominated interleukin-17D (IL-17D), is notably abundant within pulmonary confines. Nevertheless, its implication in sepsis remains somewhat enigmatic. The present study endeavors to scrutinize the participation of IL-17D in sepsis-induced acute lung injury (ALI).
Methods: The levels of IL-17D in the serum and bronchoalveolar lavage fluid (BALF) of both healthy cohorts and septic patients were ascertained through an ELISA protocol. For the creation of a sepsis-induced ALI model, intraperitoneal lipopolysaccharide (LPS) injections were administered to male C57/BL6 mice. Subsequently, we examined the fluctuations and repercussions associated with IL-17D in sepsis-induced ALI, probing its interrelation with nuclear factor erythroid 2-related factor 2 (Nrf2), alveolar epithelial permeability, and heme oxygenase-1.
Results: IL-17D levels exhibited significant reduction both in the serum and BALF of septic patients (P&lt;0.001). Similar observations manifested in mice subjected to LPS-induced acute lung injury (ALI) (P=0.002). Intraperitoneal administration of recombinant interleukin 17D protein (rIL-17D) prompted increased expression of claudin 18 and concomitant enhancement of alveolar epithelial permeability, thus, culminating in improved lung injury (P&lt;0.001). Alveolar epithelial type II (ATII) cells were identified as the source of IL-17D, regulated by Nrf2. Furthermore, a deficiency in HO-1 yielded elevated IL-17D levels (P=0.004), albeit administration of rIL-17D ameliorated the exacerbated pulmonary damage resulting from HO-1 deficiency.
Conclusion: Nrf2 fosters IL-17D production within AT II cells, thereby conferring a protective role in sepsis-induced ALI.