bluuebunny/crossref_metadata_2025_split huggingface dataset:
Desenvolvimento e análises de qualidade de comprimidos de amoxicilina produzidos dos métodos de granulação via seca
Authors: Ribeiro Angelaine Caroline , Pelissari Gabriela de Fátima , Franzini Cristina Maria 
Published: July 2023

A amoxicilina é um fármaco antimicrobiano de amplo espectro empregado na prática clínica destinada aotratamento de infecções, sobretudo daquelas acometedoras do trato respiratório. As propriedades físico-químicas e biofarmacêuticas da amoxacilina tornam o desenvolvimento de uma preparação farmacêutica com este princípio ativo um grande desafio. Neste sentido, para esta substância, é necessário considerar como barreiras no processo de desenvolvimento de um novo produto sua restrita solubilidade em meio aquoso, assim como sua susceptibilidade ao processo de hidrólise. Diante dessas considerações, a produção de comprimidos por via seca demonstra ser uma alternativa interessante para o preparo de comprimidos constituídos de amoxicilina. Além disso, esta via de preparação apresenta inúmeras vantagens sobre o processo produtivo industrial. Portanto, este trabalho teve como objetivo desenvolver comprimidos constituídos de amoxicilina por via seca de compactação e promover ensaios de controle de qualidade destes comprimidos. Para isso, foi proposta uma fórmula farmacêutica empregando-se a amoxicilina em uma dose terapêutica de 500mg, tendo como adjuvantes farmacotécnicos a celulose microcristalina, o estearato de magnésio, a lactose anidra e a croscarmelose sódica. A preparação foi submetida posteriormente a ensaios de controle de qualidade representados por: avaliação de aspecto, peso médio, friabilidade, tempo de desintegração e perfil de dissolução. Foi possível garantir a obtenção de comprimidos constituídos de amoxicilina com perfil de dissolução condizentes com preparações de liberação imediata, bem como a adequabilidade desta diante dos demais ensaios de controle de qualidade.
Does Learning English Contribute to Ensuring Patient Safety? Egyptian Cardiac Nurses Perceptions
Authors: Wannas Amr Selim 
Published: July 2023

Background: The effect of English is indisputable in the profession of nursing, where English is increasingly becoming the medium of instruction and communication. Therefore, the principal goal of the study was to examine the perceptions of Egyptian nurses in reference to the English language effect on patient safety.
Purpose: The study was implemented in a cardiothoracic Centre that provides free-of-charge care for patients with heart diseases.
Design and methods: In this pursuit, a mixed-method approach was employed as two data collection instruments were constructed and utilized following the review of literature and based on the patient international safety goals recommended by the Joint Commission International (JCI). The first instrument is a 39-item questionnaire and the second is a semi-structured interview. The number of nurses participated in the study was (n=94); 86 nurses participated in the questionnaire whereas eight expert nurses were recruited for the semi-structured interview.
Results: The results revealed that the English language is an essential element in the process of ensuring patient safety for Egyptian nurses and its effect is revealed through the international safety goals. Based on the study, nurses are advised to be proficient in using the English language so as to provide the best possible care for cardiac patients.
ISSUES OF AGREED WITH THE LESSOR OF THE VEHICLE SUBLEASE
Authors: Поваров Ю.С. 
Published: July 2023

В статье в системном ключе анализируется проблематика необходимости получения в силу закона или соглашения сторон согласия арендодателя на сдачу в субаренду транспортного средства (на условиях аренды с экипажем и (или) без экипажа); особый акцент делается на вопросе о последствиях игнорирования разрешительного порядка (в ракурсе (не)допустимости применения ст. 173.1 ГК РФ).
The article analyzes in a systematic way the problem of the need to obtain, by virtue of law or agreement of the parties, the consent of the lessor to sublease the vehicle (on a lease with a crew and (or) without a crew); special emphasis is placed on the issue of the consequences of ignoring the permissive procedure (in the perspective of (in)admissibility of applying Article 173.1 of the Civil Code of the Russian Federation).
Regulation of neighbor relations when placing and operating parking lots common use
Authors: Аминева А.Ю. 
Published: July 2023

Статья посвящена исследованию соседских правоотношений при создании (размещении) и эксплуатации парковочных мест. Установлено, что нормативное регулирование подобных отношений в основном осуществляется нормами публичного законодательства, частно-правовое регулирование довольно скудное и требует дальнейшего совершенствования в сторону конкретизации прав и обязанностей владельцев транспортных средств, совместно пользующихся парковками общего пользования.
The article is devoted to the study of neighborly legal relations in the creation (placement) and operation of parking spaces. It has been established that the normative regulation of such relations is mainly carried out by the norms of public law, private law regulation is rather meager and requires further improvement towards specifying the rights and obligations of vehicle owners sharing public parking lots.
PROBLEMS OF LEGAL REGULATION OF TAXI AGGREGATOR ACTIVITY
Authors: Балякина Е.Б. 
Published: July 2023

В настоящей статье рассматриваются проблемы правого регулирования процесса перевозок, организованного операторами такси через агрегатора. Участие оператора такси в процессе перевозок вызывает немало вопросов, в частности, кто отвечает за ненадлежащее оказание услуги по перевозке пассажиров – водитель такси, оператор такси или же организация, предоставившая автомобиль и водителя для перерезки. Автором настоящей статьи предпринята попытка изложить решение обозначенных вопросов.
This article discusses the problems of legal regulation of the transportation process organized by taxi operators through an aggregator. The participation of a taxi operator in the transportation process raises many questions, in particular, who is responsible for the improper provision of passenger transportation services – a taxi driver, a taxi operator, or an organization that provided a car and a driver for cutting. The author of this article has attempted to present the solution of these issues.
7 - Decolonization and Popular Contestation in Sierra Leone: The Peasant War of 1955-1956
Authors: Ismail O. D. Rashid  
Published: July 2023

Between 1955 and 1956, peasants in the northern region of Sierra Leone, following the steps of workers in Freetown, launched an insurrection to protest colonial taxation and the exploitative practices of their paramount chiefs and local ruling elite. The insurrection, which started as a protest against the paramount chief of Port Loko, Alkali Modu, soon engulfed all of the districts in the northern region and parts of the southern region. Through their violent actions, the peasants indicated that the oppressive practices and the excessive financial demands by the paramount chiefs and the state were neither tenable nor acceptable during the decolonization era. Their actions also illustrated the inadequacy of ‘traditional’ and ‘paternalistic’ forms of governance that had been the linchpin of British colonialism in Sierra Leone, and which still underpinned the chieftaincy and new local institutions that had been created by the departing British. The peasant insurrection interrupted the tranquil process of decolonization being executed between the Sierra Leonean elite and the British, and it took a heavy toll on the national and local security forces. However, the subsequent public investigation and acknowledgement of the peasant grievances by the Cox Commission of Inquiry as well as the restitutive actions by the SLPP government affirmed the legitimacy of many of the peasant claims. With the 1955-56 insurrection, it could be argued that the peasants in northern Sierra Leone had not only rudely interrupted the process of decolonization, they had forcib y renegotiated the terms of a ‘new’ Sierra Leone political order in their favour.
Hand grip strength is inversely associated with total daily insulin dose requirement in patients with type 2 diabetes mellitus: a cross-sectional study
Authors: Chen Da-shuang , Zhu Yun-qing , Ni Wen-ji , Li Yu-jiao , Yin Guo-ping , Shao Zi-yue , Zhu Jian 
Published: July 2023

Background
Short-term (2 weeks to 3 months) insulin intensive therapy using continuous subcutaneous insulin infusion (CSII) can improve islet beta cell function and prolong glycemic remission in patients with newly diagnosed type 2 diabetes mellitus (T2DM). However, the total daily insulin dose (TDD, IU/kg/d) required to achieve near-normoglycemic control with CSII still needs to be frequently adjusted based on blood glucose monitoring. Although real-time continuous glucose monitoring (rtCGM), which measures the interstitial fluid glucose concentration continuously without much difficulty, facilitates the adjustment of insulin dosage, its adoption in the T2DM population is strictly limited by insurance coverage and lack of awareness of rtCGM among clinicians. Thus, it is of clinical significance to identify easy-to-use parameters that may allow a more rapid and accurate prediction of TDD requirement. This study aimed to explore the association between hand grip strength (HGS) and TDD requirement in patients with T2DM receiving CSII therapy.

Methods
A total of 180 eligible patients with T2DM were enrolled in the study and divided into three groups based on their HGS: low (L), medium (M), and high (H). The TDD requirement was calculated on day 7 or 8 of CSII treatment. Anthropometric parameters, including HGS, skeletal muscle mass, skeletal muscle index (SMI) and 6-m gait speed, and laboratory data, were collected on the morning of the second day after admission, within the first 24 h of CSII therapy. These parameters were used to identify significant predictors of TDD requirement using Pearson or Spearman correlation test, and stepwise multiple regression analysis.

Results
There were no significant differences in age, duration of T2DM, waist-to-hip ratio (WHR), body mass index (BMI), blood pressure, liver function, estimated glomerular filtration rate, triglyceride, total cholesterol, glycosylated hemoglobin A1c (HbA1c), homeostatic model assessment of insulin resistance (HOMA-IR), and homeostasis model assessment of beta cell function (HOMA-β) among the groups. The H group had higher body muscle mass-to-fat ratio (BMFR), skeletal muscle mass-to-fat ratio (SMFR), SMI, 6-m gait speed, and lower TDD requirement than the M and L groups. The HGS negatively correlated with TDD requirement (r = −0.33, p < 0.001) after adjusting for sex, age, BMI, WHR, HbA1c, Ln (HOMA-β), Ln (HOMA-IR), Ln (BMFR), Ln (SMFR), SMI, and 6-m gait speed. Multivariate stepwise regression analysis indicated that HGS was an independent predictor of TDD requirement in patients with T2DM (β = −0.45, p < 0 001).

Conclusion
Lower HGS is associated with an increased TDD requirement in T2DM patients. HGS may facilitate the prediction of TDD requirement in T2DM patients receiving CSII therapy.
Varietal Evaluation of Pak Choi (Brassica rapa subsp. Chinensis) under Agro-climatic Conditions of Prayagraj, India
Authors: Pyngrope Barilang , Singh Yash Kumar , Prasad V. M. 
Published: July 2023

A study was conducted on the Varietal Evaluation of Pak Choi using ten different varieties at the Horticultural Farm, Department of Horticulture, Sam Higginbottom University of Agriculture, Technology and Sciences, Prayagraj (Uttar Pradesh). This study was carried out to determine the most suitable cultivar of Pak Choi under the agro-climatic conditions of Prayagraj during the winter growing season in 2022. The observations were recorded on various growth and yield contributing characters. At the end of the research, it is evident that Pak Choi White Stem was found to be superior on the basis of growth, having the maximum plant height (22.57cm) and gross weight (133.75g). In terms of yield/ha (q), Pak Choi White Stem (70.67) and Desi Pak Choi (69.22) was found to be superior. In terms of economics, the maximum gross return per hectare was obtained by Pak Choi White Stem i.e. 212010 INR followed by Desi Pak Choi i.e.,207660 INR.
Empowerment of Rural Women through Utilization of SHGs Services in Samastipur District of Bihar, India
Authors: Punya Sakshi , Mazhar Syed H. 
Published: July 2023

The present study aimed at analyzing the performance of Self Help Group (SHGs) in Bihar with especial reference to Samastipur district. The study revealed that the young women are 46.67 per cent in the selected area, 96.67 per cent of the members were found to be literate and remaining 3.33 per cent were illiterate. Majority (58.34 %) of the Women Self Help Group (WSHG) members belonged to Other Backward Class (OBC) caste group, 67.50 per cent were engaged in farming main occupation, 61.67 per cent members of WSHGs possessed semi cemented houses. The majority of respondents 55.83 per cent had less than 1 ha land, 55.00 per cent respondents had their annual income from Rs. 1.0 lac to 2.0 lac per annum from all sources because of people were not well aware about agriculture due to lake of interest to get knowledge about agriculture.
Data regarding utilization level of respondents in women empowerment programmed that the more than half of the respondents (63.33%) had medium level utilization level of respondents in women empowerment programmed. Most of them joined SHGs to meet their family expenses and of them to meet unexpected expenditure. Monthly savings is high after joining SHGs as compares before joining. Most of them promote their savings and 20.83% increase their family income and improves living standard.
Identifying Factors of Operative Efficiency in Head and Neck Free Flap Reconstruction
Authors: Alhefzi Muayyad , Redwood Jennifer , Hatchell Alexandra C. , Matthews Jennifer L. , Hill William K. F. , McKenzie C. David , Chandarana Shamir P. , Matthews T. Wayne , Hart Robert D. , Dort Joseph C. , Schrag Christiaan 
Published: July 2023

ImportanceHead and neck oncological resection and reconstruction is a complex process that requires multidisciplinary collaboration and prolonged operative time. Numerous factors are associated with operative time, including a surgeon’s experience, team familiarity, and the use of new technologies. It is paramount to evaluate the contribution of these factors and modalities on operative time to facilitate broad adoption of the most effective modalities and reduce complications associated with prolonged operative time.ObjectiveTo examine the association of head and neck cancer resection and reconstruction interventions with operative time.Design, Setting, and ParticipantsThis large cohort study included all patients who underwent head and neck oncologic resection and free flap–based reconstruction in Calgary (Alberta, Canada) between January 1, 2007, and March 31, 2020. Data were analyzed between November 2021 and May2022.InterventionsThe interventions that were implemented in the program were classified into team-based strategies and the introduction of new technology. Team-based strategies included introducing a standardized operative team, treatment centralization in a single institution, and introducing a microsurgery fellowship program. New technologies included use of venous coupler anastomosis and virtual surgical planning.Main Outcomes and MeasuresThe primary outcome was mean operative time difference before and after the implementation of each modality. Secondary outcomes included returns to the operating room within 30 days, reasons for reoperation, returns to the emergency department or readmissions to hospital within 30 days, and 2-year and 5-year disease-specific survival. Multivariate regression analyses were performed to examine the association of each modality with operative time.ResultsA total of 578 patients (179 women [30.9%]; mean [SD] age, 60.8 [12.9] years) undergoing 590 procedures met inclusion criteria. During the study period, operative time progressively decreased and reached a 32% reduction during the final years of the study. A significant reduction was observed in mean operative time following the introduction of each intervention. However, a multivariate analysis revealed that team-based strategies, including the use of a standardized nursing team, treatment centralization, and a fellowship program, were significantly associated with a reduction in operative time.ConclusionsThe results of this cohort study suggest that among patients with head and neck cancer, use of team-based strategies was associated with significant decreases in operative time without an increase in complications.
Extremely High Intrinsic Carrier Mobility and Quantum Hall Effect Of Single Crystalline Graphene Grown on Ge(110)
Authors: Guo Wang , Zhang Miao , Xue Zhongying , Chu Paul K. , Mei Yongfeng , Tian Ziao , Di Zengfeng 
Published: July 2023

AbstractThe successful synthesis of wafer‐scale single crystalline graphene on semiconducting Ge substrate has been considered a significant breakthrough toward the manufacturing of graphene‐based electronic and photonic devices; however, the assumed extremely high electrical mobility has not been found yet due to the lack of an adequate characterization method. Herein, state‐of‐the‐art transfer methods are developed to encapsulate the single crystalline graphene, which is grown on semiconducting Ge(110), in two hexagonal boron nitride (hBN) flakes, then acquire its inherent electrical mobility precisely via edge‐contact technique. It is found that single crystalline graphene grown on Ge(110) possesses a maximum carrier mobility of over 100 000 cm2 V−1 s−1 at low temperatures (2.3 K), which is superior to that obtained from graphene grown on other nonmetal substrates. Due to the extremely high mobility, well‐defined quantum Hall effect and Shubnikov‐de Haas oscillations can be observed at low temperatures as well. The study suggests that the excellent carrier mobility of graphene grown on Ge(110) may open an avenue to develop the practical graphene‐based nanodevices with high performance.
FeCl3 Catalyzed Three‐Component Synthesis of Spirochromans and Dihydrocoumarins
Authors: Pratap Singh Surya , Arora Shivani , Singh Anand 
Published: July 2023

AbstractAn efficient approach towards the synthesis of substituted spirochromans and dihydrocoumarins from a three‐component reaction involving aromatic aldehydes, phenols and phenylene dithiolanes is described. This FeCl3 catalyzed reaction utilizes either aromatic aldehydes or their acetals for condensation with phenols to generate o‐quinone methides in situ which further undergo a formal [4+2] cyclization with phenylene dithiolanes. Careful control of temperature allows direct access to dihydrocoumarins by the removal of the thioacetal moiety.
LiBr‐Mediated Cross‐Coupling towards α‐Trifluoromethylamines
Authors: Chen Yongzhi , Lin Dengkai , Yu Zijie , Dong Zhan , Song Liangliang , Chen Liang‐An 
Published: July 2023

AbstractA LiBr‐mediated cross‐coupling reaction between organozinc reagents and α‐chloro trifluoromethyl amines for modular access to α‐trifluoromethyl amines is reported. Different kinds of alkyl‐ and arylzinc reagents are compatible with this LiBr‐mediated cross‐coupling, resulting in a number of diversified α‐trifluoromethyl amines in high yields. This method features easy operation, mild reaction conditions, excellent functional group tolerance, and broad substrate scope. Preliminary mechanistic insight suggests that this cross‐coupling reaction involves α‐trifluoromethyl imine formation from α‐chloro trifluoromethyl amines under LiX (X=Cl, Br). The synthetic utility of this method is successfully demonstrated by a gram‐scale reaction and diverse product transformations.
Machine learning for accelerating screening in evidence reviews
Authors: Chappell Mary , Edwards Mary , Watkins Deborah , Marshall Christopher , Graziadio Sara 
Published: July 2023

AbstractEvidence reviews are important for informing decision‐making and primary research, but they can be time‐consuming and costly. With the advent of artificial intelligence, including machine learning, there is an opportunity to accelerate the review process at many stages, with study screening identified as a prime candidate for assistance. Despite the availability of a large number of tools promising to assist with study screening, these are not consistently used in practice and there is skepticism about their application. Single‐arm evaluations suggest the potential for tools to reduce screening burden. However, their integration into practice may need further investigation through evaluations of outcomes such as overall resource use and impact on review findings and recommendations. Because the literature lacks comparative studies, it is not currently possible to determine their relative accuracy. In this commentary, we outline the published research and discuss options for incorporating tools into the review workflow, considering the needs and requirements of different types of review.
Comparison of clinical pharmacist visits based on language preference in an urban underserved clinic: A cross‐sectional analysis
Authors: Jadoo Hailie , Klemenhagen Kristen C. , Freeman Kathryn , Philbrick Ann M. 
Published: July 2023

AbstractBackgroundPersons who prefer a language other than English, termed Non‐English Language Preferred (NELP), experience lower health literacy and additional social determinants of health challenges when compared to English Language Preferred (ELP) patients. Non‐English Language Preferred persons have the potential to benefit from comprehensive medication management (CMM) services.MethodsThis was a cross‐sectional analysis of all patients seen by a clinical pharmacist (CP) at a single, urban family medicine clinic during 2021. Statistical analysis was completed to determine if there were differences between NELP and ELP patients in number of visits, visit type and duration, number and type of medication therapy problems (MTPs), and whether the patient was seen by a physician the same day.ResultsA total of 383 patients (57.7% ELP), resulting in 815 total visits (53.5% ELP) were seen by a CP in 2021. There was no difference in the mean number of CP visits per patient (2.0 for ELP, 2.3 for NELP; p = 0.104). There was no difference in the mean number of MTPs between groups (1.9 for ELP, 2.1 for NELP; p = 0.112); however, NELP patients were more likely to have a MTP of “dose too low” (12.9 vs. 21.1%; p = 0.003). Additionally, NELP patients had 11.2% fewer virtual visits than ELP patients (p < 0.001). There were no significant differences in the type of visit (CMM vs. consult, p = 0.628), whether the visit occurred the same day as a physician visit (p = 0.064), or visit duration between groups (p = 0.740).ConclusionNon‐English Language Preferred patients were more likely to have an in‐person visit, and were more likely to have a MTP of “dose too low.” Understanding key differences in CP visits between ELP and NELP patients can help inform future CP care.