bluuebunny/crossref_metadata_2025_split huggingface dataset:
Initial management of suspected malignant pleural effusion : videothoracoscopic ambulatory indwelling pleural catheter versus talc pleurodesis, a propensity scores matched study
Authors: Baltazard Charlotte , Cunji Pierre Julien , Bylicki Olivier , Natale Claudia , Beranger Fabien , Rive Elodie , Paleiron Nicolas , Lacroix Guillaume , Avaro Jean-Philippe , Boudin Laurys , de Lesquen Henri 
Published: April 2023

Abstract
Objectives To determine if ambulatory videothoracoscopic pleural sampling followed by indwelling pleural catheter (VATS-IPC) is safe and effective comparing with videothoracoscopic talc pleurodesis (VATS-TP) reducing total pleural effusion-relative hospitalization days for patients with malignant pleural effusion (MPE).Methods. All patients who underwent either ambulatory VATS- IPC or conventional VATS-TP were extracted from a prospective database. Patients were matched one to one according to the surgical strategy (VATS-IPC versus VATS-TP) and a propensity score including six variables: age, gender, PS, type and size of effusion, dyspnoea. Primary endpoint was effusion-relative hospital stay at 3 months. Secondary endpoints were occurrence of pleurodesis, additional pleural procedures and adverse events at 3 months.Results. From 2019 to 2021, among 176 patients underwent surgical procedure whose 48 an ambulatory hybrid approach by VATS-IPC. Overall effusion-relative hospital stay at 3 months was lower in the VATS-IPC group before and after propensity score (1.80 +/-3.95 vs 6.85 +/- 6.15 days, p < 0.001). Initial management length of stay was also lower in the VATS-IPC group before and after propensity score (0.81 +/- 1.27 vs 6.02 +/- 4.83, p < 0.001). Additional pleural procedure rate (11.1 vs 10.4%, p = 1.000) and pleurodesis (72.3% vs 66.7%, p = 0.706) were similar in both of groups. VATS- TP trended to be associated with more adverse events (16.7% vs 8.7%, p = 0.396). No difference of mortality at 3 months was found (18.8% vs 16.7%, p = 1.000).Conclusions. Ambulatory VATS-IPC was associated with shorter effusion-relative hospitalization stay with equivalent pleurodesis rate at 3 months, without increased morbimortality for initial management of MPE.
Identification of a novel drug molecule for Neurodegenerative Disease from marine algae through In-silico analysis
Authors: Dhanabalan Anantha Krishnan , Kumar Praveen Kumar , Vasudevan Saranya , Chworos Arkadiusz , Velmurugan Devadasan 
Published: April 2023

Abstract
Marine algae-derived compounds were reported for their neuroprotective activities, hence they can be utilised for treating neurodegenerative ailments like Alzheimer’s Disease and Parkinson’s Disease. Marine algae are potential sources of useful compounds for the pharmaceutical, medical and cosmetics industries. Molecular Docking study has been performed with the bioactive compounds reported from Phaeophyceae (Brown Algae), Rhodophyta (Red Algae) and Chlorophyta (Green Algae) with drug target protein Acetylcholinesterase (AChE). The docking study shows that the bioactive compound Tetrafucol (-14.37 kcal/mol) has good binding affinity and energy compared with other compounds such as Eckol (-13.78 kcal/mol), Phytol (-9.74 kcal/mol), Eckstonol (-12.56 kcal/mol), Phlorofucofuroeckol B (-13.307 kcal/mol) and the co-crystal (-11.63 kcal/mol) Further, Molecular Dynamics simulations study had been carried out with AChE complex with Phlorofucofuroeckol, Tetrafucol and cocrystal (Dihydrotanshinone I) for 100ns each. MD simulations study also supports the stability and flexibility of the bioactive compounds (Tetrafucol and Phlorofucofuroeckol) within the protein.
Environmental assessment of single-chain polymer nanoparticles: prospects for cleaner production
Authors: Galant Or , Diesendruck Charles , Spatari Sabrina 
Published: April 2023

Abstract
Emerging nano-scale materials are under development for multiple uses in high-performance product applications such as advanced polymers. We apply prospective life cycle assessment (LCA) methods to evaluate alternative process scenarios for single chain polymer nanoparticles (SCNPs) synthesis through a photochemistry process, emphasizing the role of limiting solvent quantity and type used. SCNPs are promising high-performance materials with multiple potential applications in catalysts, lubricants, nanoreactors and more. However, as of today, SCNPs synthetic routes are still under development and usually require an excessive amount of solvent, imposing costly environmental impacts. In this study, we perform LCA to evaluate SCNPs production through a flow photochemical process compared to a classical batch process. We apply LCA to compare the performance of different scenarios for batch and flow processes, considering solvent recovery through vacuum distillation, atmospheric distillation, and solvent replacement. The results indicate that there are environmental benefits under the flow process over conventionally used batch processes where the solvent is recovered through atmospheric distillation, and toluene is the preferred solvent. In addition, we compare the LCA results to a common green chemistry metric known as the Environmental factor and conclude that a green metric calculation alone is insufficient. Hence, a comprehensive and systematic life cycle approach is needed to understand the environmental impacts of flow chemistry with potential scenarios prior to scaling up production.
Evaluation of Androgen Receptor Expression in Patients with Breast Cancer by 18 F-FDG PET/CT Radiomics and Clinicopathological Characteristics
Authors: Jia Tongtong , Lv Qingfu , Zhang Bin , Yu Chunjing , Sang Shibiao , Deng Shengming 
Published: April 2023

Abstract
Objective In the present study, we mainly aimed to predict the expression of androgen receptor (AR) in breast cancer (BC) patients by combing radiomic features and clinicopathological factors in a non-invasive machine learning way.Materials and Methods A total of 48 BC patients, who were initially diagnosed by 18F-FDG PET/CT, were retrospectively enrolled in this study. LIFEx software was used to extract radiomic features based on PET and CT data. The most useful predictive features were selected by the LASSO (least absolute shrinkage and selection operator) regression and t-test. Radiomic signatures and clinicopathologic characteristics were incorporated to develop a prediction model using multivariable logistic regression analysis. The receiver operating characteristic (ROC) curve, Hosmer-Lemeshow (H-L) test, and decision curve analysis (DCA) were conducted to assess the predictive efficiency of the model.Results In the univariate analysis, the metabolic tumor volume (MTV) was significantly correlated with the expression of AR in BC patients (p < 0.05). However, there only existed feeble correlations between estrogen receptor (ER), progesterone receptor (PR), and AR status (p = 0.127, p = 0.061, respectively). Based on the binary logistic regression method, MTV, SHAPE_SphericityCT (CT Sphericity from SHAPE), and GLCM_ContrastCT (CT Contrast from grey-level co-occurrence matrix) were included in the prediction model for AR expression. Among them, GLCM_ContrastCT was an independent predictor of AR status (OR = 9.00, p = 0.018). The area under the curve (AUC) of ROC in this model was 0.832. The p-value of the H-L test was beyond 0.05.Conclusions A prediction model combining radiomic features and clinicopathological characteristics could be a promising approach to predict the expression of AR and noninvasively screen the BC patients who could benefit from anti-AR regimens.
Tumor location impacts the development of radiation necrosis in benign intracranial tumors
Authors: Demetz Matthias , Mangesius Julian , Krigers Aleksandrs , Nevinny-Stickel Meinhard , Thomé Claudius , Freyschlag Christian F. , Kerschbaumer Johannes 
Published: April 2023

Abstract
Background
Radiation necrosis (RN) is a possible late complication of stereotactic radiosurgery (SRS), but only few risk factors are known. The aim of this study was to assess tumor location in correlation to the development of radiation necrosis for skull base (SB) and non-skull base tumors.
Methods
All patients treated with radiosurgery for benign neoplasms (2004-2020) were retrospectively evaluated. The clinical, imaging and medication data was gained and largest axial tumor diameter was determined using MRI scans in T1 weighted imaging with gadolinium. The diagnosis of RN was established using imaging parameters. Patients with tumors located at the skull base were compared to patients with tumors in non-skull base locations.
Results
205 patients could be included. 157 tumors (76.6%) were located at the SB and compared to 48 (23.4%) non-SB tumors. Among SB-tumors, the most common were vestibular schwannomas (125 cases) and meningiomas (21 cases). 32 (15.6%) patients developed RN after median 10 (IqR 5-12) months. 62 patients (30.2%) had already undergone at least one surgical resection.
In multivariate Cox regression, SB-tumors showed a significantly lower risk of radiation necrosis with a Hazard Ratio (HR) of 0.252, p<0.001, independently of the applied radiation dose. Furthermore, higher radiation doses had a significant impact on the occurrence of RN (HR 1.372, p=0.002).
Conclusion
The risk for development of RN for SB tumors appears to be low, but should not be underestimated. No difference was found between recurrent tumors and newly diagnosed tumors, which may support the value of radiosurgical treatment for patients with recurrent SB tumors.
Transmission probability of gas molecules through porous layers at Knudsen diffusion
Authors: Macher Wolfgang , Skorov Yuri , Kargl Günter , Laddha Sunny , Zivithal Stephan 
Published: April 2023

Abstract
Gas flow through layers of porous materials plays a crucial role in technical applications, geology, petrochemistry and space sciences (e.g. fuel cells, catalysis, shale gas production and outgassing of volatiles from comets). In many applications the Knudsen regime is predominant, where the pore size is small compared to the mean free path between intermolecular collisions. In this context common parameters to describe the gas percolation through layers of porous media are the probability of gas molecule transmission and the Knudsen diffusion coefficient of the medium. We show how probabilistic considerations on layer partitions lead to the analytical description of the permeability of a porous medium to gas flow as a function of layer thickness. The derivations are made on the preconditions that the reflection at pore surfaces is diffuse and that the pore structure is homogenous on a scale much larger than the pore size. By applying a bi-hemispherical Maxwell distribution, relations between the layer transmission probability, the half-transmission depth and the Knudsen diffusion coefficient are obtained. For packings of spheres, expressions of these parameters in terms of porosity and grain size are derived and compared with former standard models. A verification of the derived equations is given by means of numerical simulations, also giving evidence that our analytical model for sphere packing is more accurate than the former classical models.
Management of iatrogenic gallbladder perforation during laparoscopic cholecystectomy
Authors: Urakawa Shinya , Michiura Toshiya , Tokuyama Shinji , Fukuda Yasunari , Miyazaki Yasuaki , Hayashi Nobuyasu , Yamabe Kazuo 
Published: April 2023

Abstract
Purpose Iatrogenic gallbladder perforation frequently occurs during laparoscopic cholecystectomy and may increase the risk of infectious complications. The effectiveness of postoperative antibiotics and drainage in preventing infections remain unclear. The study aimed to investigate the clinical outcomes of patients with Iatrogenic gallbladder perforation during laparoscopic cholecystectomy in relation to these treatments.Methods One hundred twenty-one consecutive patients with Iatrogenic gallbladder perforation during laparoscopic cholecystectomy were enrolled. Surgeons chose the treatments for Iatrogenic gallbladder perforation: antibiotics (n = 48), drainage (n = 39), and no treatment (n = 34). Infectious complications were classified into wound infections, intra-abdominal abscesses, distant infections, and infections with unknown origin.Results The drainage group showed a nonsignificantly higher frequency of overall infectious complications than the other two groups (antibiotics vs. drainage vs. no-treatment = 14.6% vs. 23.1% vs. 11.8%, P = 0.31). The infection-positive group (n = 20) had a higher frequency of diabetes mellitus (positive vs. negative group = 52.6% vs. 17.7%, P = 0.0009) and lower preoperative albumin (3.8 vs. 4.1 g/dL, P = 0.0081) than the infection-negatve group. Multivariate analysis showed that a lower preoperative albumin (OR 4.90, 95% CI 1.20–20.0, P = 0.027) and the presence of diabetes mellitus (OR 5.49, 95% CI 1.62–18.6, P = 0.0063) were independent factors of overall infectious complications.Conclusions Additional treatments such as postoperative antibiotics and drainage may be unnecessary to prevent infectious complications in patients with Iatrogenic gallbladder perforation during laparoscopic cholecystectomy. diabetes mellitus and malnutrition were associated with postoperative infections. These findings should be validated in larger independent samples.
Cultivation of Ulva lactuca changes bacterial community structure and abundances of nitrogen cycling functional genes in an IMTA system
Authors: Kong Shuo , Chen Zhao , Zhao Fazhen , Liu Qingbing , Li Jian 
Published: April 2023

Abstract
To study nitrogen removal by Ulva lactuca and its effects on the structure of the bacterial community and abundance of nitrogen cycle functional genes in the ‘sea cucumber–shrimp–crab–fish’ integrated multi-trophic aquaculture (IMTA) system, we analysed bacterial community composition by Illumina MiSeq high-throughput sequencing and nitrogen cycling functional gene levels by real-time quantitative PCR in water and sediment with (Y) and without the presence of U. lactuca (N). Diversity and abundance indices, including Sobs, Shannon, Ace, and Chao1, were higher in Group Y water and sediment. In the water, the predominant phyla were Proteobacteria in Group Y and Cyanobacteria in Group N in September. Flavobacteriaceae and Rhodobacteraceae were the dominant families in Group Y and Group N in October and November, respectively. In the sediment, Bacillaceae was the dominant family in Group Y throughout the experimental period, whereas Desulfocapsaceae was the dominant family in Group N in October and November. Regarding nitrogen cycle functional genes, millions of Amx, nosZ, nxrB, and nrfA genes were detected in both water and sediment. The abundances of nifH, amoA, nxrB, norB, and nrfA genes were higher in Group Y than those in Group N, which can improve ammonia removal without nitrogen loss. In this study, a potential novel approach was proposed to enhance the development of sustainable aquaculture, promote the nitrogen cycle, and remediate and optimise the water environment by cultivating bacteria and algae, according to the effects of U. lactuca on water quality, bacterial communities, and abundance of functional nitrogen cycling genes in IMTA systems.
Synergistic immunoprotection by Oma87 and Bap against Acinetobacter baumannii sepsis model
Authors: Mansouri Mobina , Sadeghpoor Masoomeh , Ghaini Mohammad Hossein , Rasooli Iraj 
Published: April 2023

Abstract

Acinetobacter baumannii is the leading cause of nosocomial infection. A surface protein commonly known as biofilm associate protein (Bap) has been identified in a bloodstream isolate of A. baumannii. Bap of A. baumannii is involved in intercellular adhesion within the mature biofilm. Outer membrane protein Acinetobacter 87kDa (Oma87) or β-barrel assembly machinery A (BamA) has been introduced as an immunogenic outer membrane protein via in silico reverse vaccinology. The current research examines the synergistic effect of immunization of mice with both recombinant proteins viz., Oma87 and Bap. Antibodies were raised to the proteins. The mice were challenged with A. baumannii ATCC 19606 and the bacterial burden was enumerated in the mice’s livers, spleens, and lungs followed by histological examination. IgG levels significantly increased, and a significant (p < 0.0001) difference was observed between bacterial burdens in the internal organs of the actively and passively immunized groups. Female BALB/c mice weighing 20-25g, were divided into 4 groups of 14 mice each viz., control, Oma87, Bap, Oma87-Bap groups. The proteins were individually immunogenic, but the combination of both proteins had a synergistic protection property. This is further supported by the histological examination. Based on the results, the combination of Oma87 and Bap may be considered a promising vaccine candidate against A. baumannii.
Uncontrollable Elevating D-dimer During Pregnancy and Formation of Fetal Umbilical Artery Thrombosis: a Case Report
Authors: Lin Changsheng , Zhan Jun , Xiao Xue 
Published: April 2023

Abstract
Background: Elevated levels of d-dimer during pregnancy are thought to be associated with adverse outcomes of pregnancy. Some obstetrician suspect maternal hypercoagulability may lead placenta or umbilical vascular thrombosis, which could cause fetal death in third trimester. However those hypothesis is lack of evidence of evidence-based medicine.Our case is unique because we regular screening level of d-dimer since first trimester. And we had ran scrutinize detailed inspection in other possible causes of umbilical artery thrombosis, including fetal chromosome abnormalities, umbilical cord abnormalities, immunological abnormalities, which all show negative results. This leads us to the conclusion that maternal hypercoagulability can directly lead to the formation of umbilical artery thrombosis.
Case presentation: A 29-year-old patient, a primigravida, was revealed the elevating d-dimer levels of 0.51mg/L in early pregnancy(normal level <0.5mg/L). With the clinical experience, the attending doctor considered the elevation of d-dimer levels were prompting a high risk of venous thromboembolism and spontaneous abortion potential and opted to treat the patient with low molecular weight heparin. After treatment,the level of d-dimer still sharply raising.Obstetrician choose to stop treatment in 36 gestational weeks.After tow weeks fetal death occurs. Postpartum pathological analysis confirmed formation of fetal umbilical artery thrombosis.
Conclusions: Maternal hypercoagulable state could cause umbilical vascular thrombosis.As a reliable indicator of coagulation function, it’s maybe necessary for regular screening the level of d-dimer for pregnant women in different trimester.The cut off values of d-dimer in different gestational weeks should be determined according to different race and inspection methods. Low molecular weight heparin maybe effective treatment for pregnant women with abnormal elevation of d-dimer.
Lack of Alignment between Surgeon Priorities and Patient Expectations in Total Joint Arthroplasty
Authors: Shah Harsh N. , Barrett Andrew A. , Le Patrick H. , Arora Prerna , Kamal Robin N. , Amanatullah Derek F. 
Published: April 2023

Abstract
Background: Healthcare systems are shifting toward “patient-centered” care often without assessing the values important to patients. Analogously, the interests of the patient may be disparate with physician interests, as pay-for-performance models become common. The purpose of the study was to determine which medical preferences are essential for patients during their surgical care.
Methods: This prospective, observational study surveyed 102 patients who had undergone a primary knee replacement and/or hip replacement surgery about hypothetical scenarios regarding their surgical experience. Data analysis included categorical variables presented as a number and percent, while continuous variables presented as mean and standard deviation. Statistical analysis for anticoagulation data included the Pearson chi-square test and one-way ANOVA test.
Results: A large majority, 73 patients (72%), would not pay to have a four-centimeter or smaller incision. The remaining 29 patients (28%) would prefer to have a four-centimeter or smaller incision and would pay a mean of $1,328 ± 1,629 for that day. A significant number of patients preferred not to use anticoagulation (p = 0.019); however, the value attributed to avoiding a specific method of anticoagulation was found not to be significant (p = 0.507).
Conclusions: The study determined the metrics prioritized by hospitals and surgeons are not important to the majority of patients when they evaluate their own care. These disconnects in the entitlements patients expect and receive can be solved by including patients in discussions with physicians and hospital systems.
Exogenous carbon addition reduces soil organic carbon: the effects of fungi on soil carbon priming exceed those of bacteria on soil carbon sequestration
Authors: Zhang Limin , Wang Yang , Chen Jin , Li Fangbing , Zhang Chengfu , Cao Yang , Cai Guojun , Yu Lifei 
Published: April 2023

Abstract
Aims Soil organic carbon (SOC) forms the largest terrestrial organic C pool, which is regulated by the complex connections between exogenous C input, microbial activity, and SOC turnover. Few studies have examined the changes in SOC due to microbial activity after exogenous C inputs in karst lime soils in China. We aimed to quantify the responses of soil organic carbon to exogenous carbon.
Methods the 13C isotope tracer technique was employed to investigate the priming effect on typical lime soil of 13C-litter and 13C-CaCO3 through a mineralization-incubation experiment. Samples were collected at 5, 10, 20, 40, 60, and 80 days of incubation and analyzed for SOC mineralization, SOC distribution across fractions (>250 μm, 53～250 μm, and <53 μm), and soil microbial diversity. A control consisting of no exogenous C addition was included.
Results SOC mineralization and SOC priming were considerably higher (15.48% and 61.00%, respectively) after litter addition compared to CaCO3. The addition of either litter or CaCO3 reduced the total organic C (TOC) and macroaggregate (>250 μm) and microaggregate (53～250 μm) C fractions by 2150.13, 2229.06, and 1575.06 mg C kg–1 Cbulk on average and increased the mineral associated C fraction (<53 μm) by 1653.98 mg C kg–1 Cbulk. As the incubation time extended, a significantly positive correlation was apparent between SOC priming and soil fungal diversity, as well as between the mineral associated C fraction and soil bacterial diversity. The effect of soil fungal diversity on SOC priming (R = 0.40, P = 0.003) significantly exceeded that of bacterial diversity on SOC sequestration (R = 0.27, P = 0.02).
Conclusions Our results reveal that after adding litter or CaCO3, soil fungi stimulate SOC mineralization and decomposition and that soil bacteria enhance SOC sequestration, with the effects of fungi being more pronounced. These findings can provide a theoretical basis for understanding C sequestration and emission reduction in karst lime soils.