bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluating the efficacy of human dental pulp stem cells and scaffold combination for bone regeneration in animal models: a systematic review and meta-analysis
Authors: Namjoynik Amin , Islam Md Asiful , Islam Mohammad 
Published: May 2023

Abstract
Introduction
Human adult dental pulp stem cells (hDPSC) and stem cells from human exfoliated deciduous teeth (SHED) hold promise in bone regeneration for their easy accessibility, high proliferation rate, self-renewal and osteogenic differentiation capacity. Various organic and inorganic scaffold materials were pre-seeded with human dental pulp stem cells in animals, with promising outcomes in new bone formation. Nevertheless, the clinical trial for bone regeneration using dental pulp stem cells is still in its infancy. Thus, the aim of this systematic review and meta-analysis is to synthesise the evidence of the efficacy of human dental pulp stem cells and the scaffold combination for bone regeneration in animal bone defect models.

Methodology
This study was registered in PROSPERO (CRD2021274976), and PRISMA guideline was followed to include the relevant full-text papers using exclusion and inclusion criteria. Data were extracted for the systematic review. Quality assessment and the risk of bias were also carried out using the CAMARADES tool. Quantitative bone regeneration data of the experimental (scaffold + hDPSC/SHED) and the control (scaffold-only) groups were also extracted for meta-analysis.

Results
Forty-nine papers were included for systematic review and only 27 of them were qualified for meta-analysis. 90% of the included papers were assessed as medium to low risk. In the meta-analysis, qualified studies were grouped by the unit of bone regeneration measurement. Overall, bone regeneration was significantly higher (p < 0.0001) in experimental group (scaffold + hDPSC/SHED) compared to the control group (scaffold-only) (SMD: 1.863, 95% CI 1.121–2.605). However, the effect is almost entirely driven by the % new bone formation group (SMD: 3.929, 95% CI 2.612–5.246) while % BV/TV (SMD: 2.693, 95% CI − 0.001–5.388) shows a marginal effect. Dogs and hydroxyapatite-containing scaffolds have the highest capacity in % new bone formation in response to human DPSC/SHED. The funnel plot exhibits no apparent asymmetry representing a lack of remarkable publication bias. Sensitivity analysis also indicated that the results generated in this meta-analysis are robust and reliable.

Conclusion
This is the first synthesised evidence showing that human DPSCs/SHED and scaffold combination enhanced bone regeneration highly significantly compared to the cell-free scaffold irrespective of scaffold type and animal species used. So, dental pulp stem cells could be a promising tool for treating various bone diseases, and more clinical trials need to be conducted to evaluate the effectiveness of dental pulp stem cell-based therapies.
Mesenchymal stem cells transplantation combined with IronQ attenuates ICH-induced inflammation response via Mincle/syk signaling pathway
Authors: Yang Guoqiang , Kantapan Jiraporn , Mazhar Maryam , Bai Xue , Zou Yuanxia , Wang Honglian , Huang Bingfeng , Yang Sijing , Dechsupa Nathupakorn , Wang Li 
Published: May 2023

Abstract
Background
Intracerebral hemorrhage (ICH) is a severe brain-injured disease accompanied by cerebral edema, inflammation, and subsequent neurological deficits. Mesenchymal stem cells (MSCs) transplantation has been used as a neuroprotective therapy in nervous system diseases because of its anti-inflammatory effect. Nevertheless, the biological characteristics of transplanted MSCs, including the survival rate, viability, and effectiveness, are restricted because of the severe inflammatory response after ICH. Therefore, improving the survival and viability of MSCs will provide a hopeful therapeutic efficacy for ICH. Notably, the biomedical applications of coordination chemistry-mediated metal-quercetin complex have been verified positively and studied extensively, including growth-promoting and imaging probes. Previous studies have shown that the iron-quercetin complex (IronQ) possesses extraordinary dual capabilities with a stimulating agent for cell growth and an imaging probe by magnetic resonance imaging (MRI). Therefore, we hypothesized that IronQ could improve the survival and viability of MSCs, displaying the anti-inflammation function in the treatment of ICH while also labeling MSCs for their tracking by MRI. This study aimed to explore the effects of MSCs with IronQ in regulating inflammation and further clarify their potential mechanisms.

Methods
C57BL/6 male mice were utilized in this research. A collagenase I-induced ICH mice model was established and randomly separated into the model group (Model), quercetin gavage group (Quercetin), MSCs transplantation group (MSCs), and MSCs transplantation combined with IronQ group (MSCs + IronQ) after 24 h. Then, the neurological deficits score, brain water content (BWC), and protein expression, such as TNF-α, IL-6, NeuN, MBP, as well as GFAP, were investigated. We further measured the protein expression of Mincle and its downstream targets. Furthermore, the lipopolysaccharide (LPS)-induced BV2 cells were utilized to investigate the neuroprotection of conditioned medium of MSCs co-cultured with IronQ in vitro.

Results
We found that the combined treatment of MSCs with IronQ improved the inflammation-induced neurological deficits and BWC in vivo by inhibiting the Mincle/syk signaling pathway. Conditioned medium derived from MSCs co-cultured with IronQ decreased inflammation, Mincle, and its downstream targets in the LPS-induced BV2 cell line.

Conclusions
These data suggested that the combined treatment exerts a collaborative effect in alleviating ICH-induced inflammatory response through the downregulation of the Mincle/syk signaling pathway following ICH, further improving the neurologic deficits and brain edema.
Paralinguistic and spectral feature extraction for speech emotion classification using machine learning techniques
Authors: Liu Tong , Yuan Xiaochen 
Published: May 2023

AbstractEmotion plays a dominant role in speech. The same utterance with different emotions can lead to a completely different meaning. The ability to perform various of emotion during speaking is also one of the typical characters of human. In this case, technology trends to develop advanced speech emotion classification algorithms in the demand of enhancing the interaction between computer and human beings. This paper proposes a speech emotion classification approach based on the paralinguistic and spectral features extraction. The Mel-frequency cepstral coefficients (MFCC) are extracted as spectral feature, and openSMILE is employed to extract the paralinguistic feature. The machine learning techniques multi-layer perceptron classifier and support vector machines are respectively applied into the extracted features for the classification of the speech emotions. We have conducted experiments on the Berlin database to evaluate the performance of the proposed approach. Experimental results show that the proposed approach achieves satisfied performances. Comparisons are conducted in clean condition and noisy condition respectively, and the results indicate better performance of the proposed scheme.
Wellposedness and controllability results of stochastic integrodifferential equations with noninstantaneous impulses and Rosenblatt process
Authors: Kasinathan Ravikumar , Kasinathan Ramkumar , Sandrasekaran Varshini , Nieto Juan J. 
Published: May 2023

AbstractThe purpose of this work is to investigate a novel class of noninstantaneous impulsive stochastic integrodifferential equations (SIDEs) driven by Brownian motion and Rosenblatt process. We construct a new set of adequate assumptions for the existence and uniqueness of mild solutions using stochastic analysis, analytic semigroup theory, integral equation theory, and a fixed point methodology. Additionally, we study the asymptotic behavior of mild solutions and provide stochastic system controllability results. Finally, we include an example to illustrate the application of our main findings.
Finite element method-enhanced neural network for forward and inverse problems
Authors: Meethal Rishith E. , Kodakkal Anoop , Khalil Mohamed , Ghantasala Aditya , Obst Birgit , Bletzinger Kai-Uwe , Wüchner Roland 
Published: May 2023

AbstractWe introduce a novel hybrid methodology that combines classical finite element methods (FEM) with neural networks to create a well-performing and generalizable surrogate model for forward and inverse problems. The residual from finite element methods and custom loss functions from neural networks are merged to form the algorithm. The Finite Element Method-enhanced Neural Network hybrid model (FEM-NN hybrid) is data-efficient and physics-conforming. The proposed methodology can be used for surrogate models in real-time simulation, uncertainty quantification, and optimization in the case of forward problems. It can be used to update models for inverse problems. The method is demonstrated with examples and the accuracy of the results and performance is compared to the conventional way of network training and the classical finite element method. An application of the forward-solving algorithm is demonstrated for the uncertainty quantification of wind effects on a high-rise buildings. The inverse algorithm is demonstrated in the speed-dependent bearing coefficient identification of fluid bearings. Hybrid methodology of this kind will serve as a paradigm shift in the simulation methods currently used.
Analysis of the relation between adverse events and overall survival in patients treated with pembrolizumab as a first-line treatment for metastatic NSCLC
Authors: Faoro Lisa , Brusegan Adriana , Russi Alberto , Calderone Vincenzo , Martelli Alma , Marranconi Ettore , Carpanese Debora , Berti Elena , Coppola Marina 
Published: May 2023

Abstract
Background
Many trials supported pembrolizumab as a first-line monotherapy to significantly improve overall survival (OS) in selected patients with previously untreated metastatic Non–Small Cell Lung Cancer (mNSCLC) and a PD-L1 TPS of ≥50% without EGFR/ALK mutations. The aim of this study was to reveal the correlation between OS and adverse events in real-world settings after 42 months.

Methods
This retrospective observational study involved 98 patients with mNSCLC, TPS ≥ 50%, and no EGFR/ALK aberrations. Patients were treated with pembrolizumab (200 mg q3w) as a first-line treatment. Clinical data, including PD-L1 expression, Performance Status (ECOG-PS), treatment duration, toxicity, and outcomes were retrieved from local electronic medical records and from the Italian Regulatory Agency Registry.

Results
The cohort’s main characteristics were as follows: median age 73 [44-89] years, 64.3% were male and 35.7% were female, an ECOG-PS score of 0 (n = 73) and 1 or 2 (n = 25), and a PD-L1 > 90% in 29.6% of patients. The entire cohort had stage IV NSCLC at diagnosis. The median number of cycles was 8.5 at a median follow-up of 13 months. The median OS of 13.6 months (95% CI: 11.7-NA) was not influenced by sex and PD-L1, but was significantly associated with ECOG-PS (p = 0.02). Immune-Related Adverse Events (irAEs) occurred in 77.5% of patients (30.1% cutaneous, 27.5% gastrointestinal, and 20.4% endocrinological), but no grade 4 or 5 irAEs were identified. Patients experiencing any type of toxicity had a significantly longer median OS (20.39 months, 95% CI: 13.08-NA) than those with no toxicities (6.46 months, 95% CI: 1.41-NA, p = 0.006).

Conclusion
The percentage of irAEs detected was comparable to that reported in KEYNOTE-024 and KEYNOTE-042. These real-world findings demonstrated the significant correlation between OS and cutaneous toxicities.
Discrimination of Borderline Personality Disorder (BPD) and Attention-Deficit/Hyperactivity Disorder (ADHD) in adolescents: Spanish version of the Borderline Personality Features Scale for Children-11 Self-Report (BPFSC-11) Preliminary results
Authors: Calvo Natalia , Marin Jorge Lugo , Vidal Raquel , Sharp Carla , Duque Juan D. , Ramos-Quiroga Josep-Antoni , Ferrer Marc 
Published: May 2023

Abstract
Background
Although the diagnosis of Borderline Personality Disorder (BPD) during adolescence has been questioned, many recent studies have confirmed its validity. However, some clinical manifestations of BPD could be identifiable in adolescents with other pathologies, such as Attention-Deficit/Hyperactivity Disorder (ADHD). The objective of the present study is to examine the capacity of the self-report Borderline Personality Features Scale Children-11 (BPFSC-11) to discriminate between BPD and ADHD adolescents.

Methods
One hundred and forty-five participants were grouped based on their diagnosis: 58 with BPD, 58 with ADHD, and 29 healthy volunteers as a control group. Between-group differences and the ROC curve were performed to test if the total score for the BPFSC-11 and/or its factors can significantly discriminate between BPD and other adolescent groups.

Results
The results show that the total BPFSC-11 score has good discriminant capacity among adolescents diagnosed with BPD, ADHD and healthy volunteers. However, different patterns of discriminative capacity were observed between the three groups for emotional dysregulation and impulsivity/recklessness factors.

Conclusions
Our results support the hypothesis that the BPFSC-11 is an adequate instrument for discriminating between BPD and ADHD in adolescents, who can present significant psychopathological overlap. Tools to identify BPD in adolescence, as well as for better differential diagnosis, would improve the possibility of offering specific treatments targeting these populations.
Exploring high scientific productivity in international co-authorship of a small developing country based on collaboration patterns
Authors: Mitrović Irena , Mišić Marko , Protić Jelica 
Published: May 2023

AbstractThe number of published scientific paper grows rapidly each year, totaling more than 2.9 million annually. New methodologies and systems have been developed to analyze scientific production and performance indicators from large quantities of data available from the scientific databases, such as Web of Science or Scopus. In this paper, we analyzed the international scientific production and co-authorship patterns for the most productive authors from Serbia based on the obtained Web of Science dataset in the period 2006–2013. We performed bibliometric and scientometric analyses together with statistical and collaboration network analysis, to reveal the causes of extraordinary publishing performance of some authors. For such authors, we found significant inequality in distribution of papers over journals and countries of co-authors, using Gini coefficient and Lorenz curves. Most of the papers belong to multidisciplinary, interdisciplinary, and the field of applied sciences. We have discovered three specific collaboration patterns that lead to high productivity in international collaboration. First pattern corresponds to mega-authorship papers with hundreds of co-authors gathered in specific research groups. The other two collaboration patterns were found in mathematics and multidisciplinary science, mainly application of graph theory and computational methods in physical chemistry. The former pattern results in a star-shaped collaboration network with mostly individual collaborators. The latter pattern includes multiple actors with high betweenness centrality measure and identified brokerage roles. The results are compared with the later period 2014–2023, where high scientific production has been observed in some other fields, such as biology and food science and technology.
Comparative study between vertebroplasty and kyphoplasty in management of osteoporotic vertebral body fractures
Authors: Gamal Mahmoud M. , Taghyan Mohammad , Ismail Ahmed Abdalla 
Published: May 2023

Abstract
Background
Percutaneous vertebroplasty and percutaneous kyphoplasty are effective minimally invasive procedures in reducing pain and improving the quality of life in patients with osteoporotic vertebral compression fractures with different degrees, but it may lead to serious neurological complications.

Results
Twenty-five patients were included in our study. Both techniques were done under local anesthesia using bi-pedicular approach. All cases were assessed using plain radiographs pre- and post-operative, Visual Analogue Scale for pain, and modified Oswestry Disability Index for functional disability. Thirteen patients had vertebroplasty and 12 patients had kyphoplasty. The mean age for vertebroplasty group was 66.94 ± 6.71, while in kyphoplasty group, the mean age was 70.38 ± 9.21. In vertebroplasty group, there were ten females and three males, while in kyphoplasty group, there were nine females and three males. All cases had single vertebral level affection except one patient in the vertebroplasty group that had double-level affection. In vertebroplasty group, ten patients had lumbar spine affection, two patients had dorsal spine affection and one patient had combined dorsal and lumbar spine affection. In kyphoplasty group, ten patients had lumbar spine affection and two patients had dorsal spine affection. The mean post-operative Visual Analogue Scale was 0.46 and 0.50 in vertebroplasty and kyphoplasty groups, respectively. The mean post-operative modified Oswestry Disability Index became 4.15 and 4 in vertebroplasty and kyphoplasty groups, respectively. The mean post-operative local kyphotic angle was 6.0° and 6.50° in vertebroplasty and kyphoplasty groups, respectively. The mean vertebral height became 73.15% and 75% post-operatively in vertebroplasty and kyphoplasty groups, respectively. The intra-operative cement leakage occurred in three cases of vertebroplasty group and one case of kyphoplasty group (P = 0.644). The cost of kyphoplasty was very high in comparison with vertebroplasty.

Conclusions
There is no difference between vertebroplasty and kyphoplasty as regard pain relief, improved quality of life, correction of kyphotic angle, vertebral height restoration and the incidence of cement leakage except that kyphoplasty has a very high cost than vertebroplasty. Therefore, both techniques have an equal effect in treating osteoporotic vertebral compression fractures.
Spontaneous adverse drug reaction reporting during the seasonal malaria chemoprevention campaign in 2022
Authors: Rotimi Kunle , Fagbemi Babatunde , Ibinaiye Taiwo , Aiden Jimmy , Gabriel Victor , Dabes Chrysantus , Kyeshir Tapshak , Oguche Daniel , Obayemi Omolola , Biambo Aminu , Okwulu Andrew , Aidenagbon Adaeze 
Published: May 2023

Abstract
Background
Seasonal administration of antimalaria drug, sulphadoxine/pyrimethamine plus amodiaquine to children 3–59 months is a malaria preventive intervention used for the reduction of childhood malaria morbidity and mortality in area with highly seasonal malaria transmission like sub-Saharan Africa. This intervention has been deployed in Nigeria and other sub-Saharan African countries for years and may continue for more years to come either alone or combination with other novel interventions. Despite the importance of pharmacovigilance, there is currently a dearth of pharmacovigilance data in most African countries, especially in public health interventions like seasonal malaria chemoprevention campaigns. The availability of quality safety data is likely to improve the acceptability of this preventive intervention.

Results
The study identified vomiting as the most reported adverse drug reaction. Other reported reactions include weakness, fever, abdominal pain, convulsion, redness of the eyes, swollen hand/face, rash, itching, cough, headache, and excessive salivation. Using Naranjo scale, 69.2% of the reported reactions can be classified as possible; while 29.5% can be classified as probable, only 1.3% is classified as definite. 92.3% of reported adverse drug reactions were from children 12–59 months and 7.7% were from those 3–11 months. The proportion of ADRs classified according to the affected organ/system is as follows: central nervous system (10.26%), gastrointestinal (60.26%), ocular (10.26%), musculoskeletal (7.69%), and dermatological (11.53%). The study also suggests better tolerability to the seasonal malaria chemoprevention medicines with more implementation experience, as states with more implementation experiences reported fewer suspected adverse drug reactions.

Conclusions
The findings from this study provide additional information on possible adverse drug reactions during seasonal malaria chemoprevention campaigns. This additional information should be communicated to caregivers during the seasonal malaria chemoprevention campaigns as a way of building trust and improving acceptability of the intervention. Also, strengthening of the national pharmacovigilance system is vital to ensure improved timeliness, quality, and quantity of pharmacovigilance reporting on SMC intervention in Africa, as results from the study show low levels of pharmacovigilance reporting across the states.
Anti-SSA/SSB-negative primary Sjögren’s syndrome showing different clinical phenotypes: a retrospective study of 934 cases
Authors: Chen Jiaqi , He Qian , Yang Jianying , Wu TzuHua , Huang Ziwei , Zhang Yan , Liao Jiahe , Zhang Lining , Yu Xinbo , Yao Chuanhui , Luo Jing , Tao Qingwen 
Published: May 2023

Abstract
Background
Currently, only a few studies have described the general characteristics of patients with primary Sjögren’s syndrome (pSS) who tested negatives for anti-SSA and anti-SSB antibodies. We aimed to further investigate the clinical characteristics of these patients in a large sample.

Methods
Data from patients with pSS who were treated at a tertiary hospital in China between 2013 and 2022 were retrospectively analyzed. Clinical characteristics of the patients were compared between those with and without anti-SSA and anti-SSB antibody negativity. Factors associated with anti-SSA and anti-SSB negativity were identified by logistic regression analysis.

Results
Overall, 934 patients with pSS were included in this study, among whom 299 (32.0%) tested negative for anti-SSA and anti-SSB antibodies. Compared with patients testing positive for anti-SSA or anti-SSB antibodies, that testing negative for the two antibodies had a lower proportion of females (75.3% vs. 90.6%, p < 0.001) and thrombocytopenia (6.7% vs. 13.6%, p = 0.002), but a higher proportion of abnormal Schirmer I tests (96.0% vs. 89.1%, p = 0.001) and interstitial lung disease (ILD) (59.2% vs. 28.8%, p = 0.001). Anti-SSA and anti-SSB negativity was positively associated with male sex (odds ratio [OR] = 1.86, 95% confidence interval [CI]: 1.05, 3.31), abnormal Schirmer I tests (OR = 2.85, 95% CI: 1.24, 6.53), and ILD (OR = 2.54, 95% CI: 1.67, 3.85). However, it was negatively related to thrombocytopenia (OR = 0.47, 95% CI: 0.24, 0.95).

Conclusion
Approximately one third of pSS patients had anti-SSA and anti-SSB negativity. pSS patients testing negative for anti-SSA and anti-SSB showed a higher risk of abnormal Schirmer I tests and ILD, but a lower risk of thrombocytopenia.