bluuebunny/crossref_metadata_2025_split huggingface dataset:
PS-C10-1: BLOOD PRESSURE PROFILE AND CARDIO-VASCULAR FEATURES OF WOMEN WITH A PAST HISTORY OF PREECLAMPSIA
Authors: Christian Ngongang Ouankou , Garba Hawa Koubouratou Oumy Aboubakar , Annick Metogo Ntsama Junie , Loic Mekem Tatsipie , Liliane Mfeukeu Kuate , Raoul Simeni Njonnou Sylvain , Marie Tebeu Pierre , Pierre Choukem Simeon 
Published: January 2023

Introduction:
Preeclampsia increases the longterm risk of cardiovascular disease. Some of the women affected by this condition remain hypertensive after delivery. Hypertensive phenotypes such as masked hypertension, sustained hypertension, white coat hypertension and an adverse systolic night-today blood pressure (BP) ratio are often unnoticed and can only be detected with ambulatory BP monitoring (ABPM). This study aimed to determine the prevalence of hypertension using ABPM and office measurements.

Methods:
We conducted a cross- sectional study which included women who delivered between January 2015 and June 2021 and were diagnosed and followed up for preeclampsia in three major obstetrical and gynaecologic units in Yaounde. We excluded from the study all women who had a history of chronic hypertension or a known Cardiopathy. Sociodemographic data and past history were recorded, a physical exam,ecg, an ultrasound and ABPM was performed to all participants.

Results:
101 participants were included. The mean age was 30.56 years. 40.6% of women had hypertension (sustained hypertension, with sometime masked hypertension) with ABPM. Sustained hypertension was most common (26.7%), followed by masked hypertension (11.9%) and white-coat hypertension (2%). With office BP measurement, only 28.7% of women would have been diagnosed hypertensive. 29.8% of women had a disadvantageous dipping pattern. Among those that develop chronic hypertension, 18.8% had LVH at electrocardiography, 7.9% had both LVH and an abnormal left ventricular geometry on ultrasound while in normotensive women 1.9% had LVH at Ecg with 1% having both LVH and abnormal geometry at ultrasound. 20.8% of these women were obese during the follow up compared to 11.9% in the normotensive group. We had 26 patients (25,74%) with severe office hypertension and 32,3% were obeses. The fundus was normal in the majority of cases and we had no signs of neurological deficits or impaired cognition. Renal function was always normal or subnormal. Finally, we had two cases of heart failure.

Conclusion:
Many women affected by preeclampsia remain hypertensive after delivery. Masked hypertension and white-coat hypertension are risk factors for future cardiovascular disease and can only be diagnosed with ABPM. It is important to provide adequate follow-up for these women in order to intervene on the factors leading to this outcome.
PS-C10-3: THE EFFECT OF E HEALTH ESH APPLICATION ON BP MANAGEMENT PRELIMINARY RESULTS
Authors: Siafi Eirini , Konstantinidis Dimitrios , Andrikou Ioannis , Tatakis Fotis , Zamanis Ioannis , Leontinis Ioannis , Drogkaris Sotirios , Polyzos Dimitrios , Manta Eleni , Grigoriou Kalliopi , Dimitriadis Kyriakos , Tsioufis Konstantinos 
Published: January 2023

Objective:
Main issues in the treatment of hypertension are the low level of blood pressure (BP) control and the economic burden for health care systems. Mobile application with telemonitoring of BP could contribute to better control and lower costs by reducing office visits. This could be useful nowadays with difficult access to health system due to covid-19. The purpose of this study was to investigate if an innovative management strategy of hypertension, such as the use of ESH care application for smartphones combined with a dedicated platform, could improve hypertension control and replace frequent office visits.

Design and method:
30 uncontrolled hypertensive patients, treated or untreated [mean age 53 ± 9 years, mean office BP (OBP) 146.3 ± 6.2 / 92.5 ± 9 mmHg, 53% men, 33% smokers, 23% with hypercholesterolemia] were randomized to the application assisted strategy (AAS) (17 patients), where a mobile phone application was offered to communicate home BP measurements (HBPm), or to regular office visits (13 patients). Patients BP measurements (HBPm for AAS and OBP for standard care group) were evaluated in 1 and 3 months with treatment titration if uncontrolled. In all patients OBP and ambulatory BP measurement (ABPM) were evaluated in 6 months.

Results:
In both groups the reduction in OBP and ABPM was significant in 6 months. In the AAS group the reduction in systolic/diastolic OBP and 24 h systolic/diastolic BP in 6 months was -26.5 ± 5.6 / -19.4 ± 8.2 mmHg (p < 0,001) and -19.6 ± 7.7 / -13.8 ± 4.8 mmHg (p < 0.001), respectively. In the standard care group, the reduction in systolic/diastolic OBP and 24 h systolic/diastolic BP in 6 months was -22.6 ± 9.7 / -9.6 ± 11 mmHg (p < 0.005) and -18.4 ± 6.0 / - 8.8 ± 4.4 mmHg (p < 0.001). In AAS group compared to standard care group there was a greater reduction in 24 h diastolic BP (-13.8 ± 4.8 mmHg vs -8.8 ± 4.4 mmHg, p = 0.016) and in diastolic OBP (-19.4 ± 8.2 mmHg vs -9.6 ± 11.0 mmHg, p = 0.04).

Conclusions:
The present results indicate that the monitoring of patients through a mobile health tool could be useful in hypertension management as it is correlated with better BP control compared to office visits. The trial is still enrolling patients.
PS-C10-6: ASSOCIATION BETWEEN ANKLE BRACHIAL INDEX AND SEVERITY OF CORONARY ARTERY DISEASE
Authors: Tandon Akanksha , Verma Narsingh 
Published: January 2023

Objective:
To investigate ABI as a surrogate marker and predictor for severity of CAD To determine the relation between ankle brachial index and angiographic findings along with major cardiovascular risk factors in patients with suspected or at risk for coronary artery disease

Design and Method:
This hospital based observational study recruited subjects from Department of cardiology, OPD and IPD, KGMU, Lucknow who were planned for or subjected to coronary angiography or CT coronary Angio during October 2019 to September 2020. Relationship between ABI and angiographic findings was evaluated so as to include this as a screening tool in all suspected cardiovascular disease subjects having no past history of PAD and to predict the severity of CAD in future.

Results:
Among the population studied 49 subjects were ABI Positive and 161 were ABI Negative. 49 (23.33‰) subjects had ABI< 0.9 and 20(9.5‰) had ABI > 0.9 < 1.2 i.e. at intermediate risk. Out of the 49 patients 95.68‰ were males and 4.32‰ were females who were found to have low ABI i.e. less than 0.9 showing higher prevalence of low ABI in males. On applying regression analysis in which ABI was the dependent variable and vessel disease (SVD),DVD,TVD)was the independent variable it is evident that more the vessels are involved more is the severity of CAD as the coefficient value increases i.e. SVD(0.84),DVD(0.8492) and TVD(0.86) with significant p < 0.05 whereas in cases of ABI> 0.9 < 1.2 we found that the coefficient value of 0.22 for DVD patients was statistically not significant but patients with TVD having coefficient value of 0.758 is significant at p < 0.05. To analyse the atherosclerotic risk factors like diabetes, hypertension, positive family history of CAD among group 1(ABI Positive)and group 2 (ABI Negative with INTERMEDIATE RISK) showed significant association which was statistically significant with p < 0.05.

Conclusion:
Severity of CAD is associated with vessel involvement which causes derangement of ABI values. Larger randomised study groups are needed to establish the exact relationship between the various CAD risk factors and Ankle Brachial Index.
PS-C10-7: A NOVEL PROFESSIONAL AUTOMATED AUSCULTATORY BLOOD PRESSURE MONITOR FOR OFFICE USE WITH VISUAL DISPLAY OF KOROTKOFF SOUNDS: INBODY BPBIO480KV VALIDATION
Authors: Kyriakoulis Konstantinos G , Ntineri Angeliki , Theodosiadi Aikaterini , Menti Ariadni , Ntousopoulos Vasileios , Kollias Anastasios , Stergiou George S 
Published: January 2023

Objective:
A novel professional automated auscultatory upper arm-cuff blood pressure (BP) monitor (InBody BPBIO480KV) for use in the office or clinic by healthcare professionals was developed. The device records the Korotkoff sounds using an electronic stethoscope embedded to the cuff, which are reproduced and graphically displayed on the device screen during cuff deflation, and automatically interpreted to report systolic and diastolic BP values. This validation study assessed the accuracy of the device in general population according to the Association for the Advancement of Medical Instrumentation/European Society of Hypertension/International Organization for Standardization (AAMI/ESH/ISO) Universal Standard (ISO 81060-2:2018) and the ISO Amendment 1.2020-01.

Design and Method:
Subjects were recruited to fulfil the age, gender, BP, arm size and cuff distribution criteria of the AAMI/ESH/ISO Universal Standard in general population using the same arm sequential BP measurement method. Three cuffs of the test device were used for arm circumference 23–28, 28–35 and 33–42 cm.

Results:
A total of 108 subjects were recruited and 85 were analyzed (mean age 57.3 ± 15.0 [SD] years, 53 men, arm circumference 32.1 ± 5.1 cm, range 23–42 cm). For validation Criterion 1, the mean ± SD of the differences between the test device and reference BP readings (N = 255) was 0.3 ± 5.5/0.6 ± 4.7 mmHg (systolic/diastolic; pass threshold < = 5 ± 8 mmHg). For Criterion 2, the SD of the averaged BP differences between the test device and reference BP per individual (N = 85) was 3.76/3.61 mmHg (systolic/diastolic; pass threshold < = 6.95/6.91 mmHg).

Conclusions:
The InBody BPBIO480KV professional automated auscultatory BP device for office use comfortably fulfilled all the requirements of the AAMI/ESH/ISO Universal Standard (ISO 81060–2:2018) in general population and can be recommended for clinical use in adults.
PS-C10-12: HOW IS THE ESTIMATED GLOMERULAR FILTRATION RATE DISTRIBUTED BY ASSOCIATION OF THE MOST COMMON CARDIOVASCULAR RISK FACTORS IN DIABETIC PATIENTS?
Authors: Félix Rita , Machado Cátia , Glória Joana , Miguéis Inês , Damião Pedro 
Published: January 2023

Objective:
This study aims to characterize the distribution of estimated glomerular filtration rate (eGFR) in diabetic patients by association of common cardiovascular risk factors (CVRF) known as alcohol abuse (P15), tobacco abuse (P17), dyslipidemia (T93) and LDL cholesterol value, body mass index (BMI) and systolic blood pressure (sBP).

Design/method:
Cross-sectional, descriptive and analytical study. Anonymized data were obtained from users of 20 medical files who had at least one medical appointment, with at least one record of sBP, LDL, BMI and creatinine in the last 3 years until the 31st December 2021. The studied variables were sex, age, weight, BMI, creatinine, eGFR(CKD-EPI formula), target organ damage (TOD) identified by the existence of the following ICPC-2 coding: K74, K75, K76, K87 or K89, K90, K91 or K92; hypertension (K86 or K87), diabetes (T89 or T90), P15, P17, T93, at the date of the last record under study. For data collection, it was used MIM@UF®; program and the statistical analysis was performed using the R®3.6.3 program.
Cardinality diagrams were created to show the association of CVRF and eGFR, CVRF and sBP, TOD type and sBP. A prediction model for the event of eGFR< 60 mL/min/1.73m2 was also created through a logistic regression model that links the occurrence of chronic kidney disease (CKD) with the predictors HTA, Diabetes, TOD, P15, P17 and T93.

Results:
The convenience sample consisted of 2396 diabetics, of which 1214 were male, and whose mean age was 70 years (IQR = 17 years). It was found that 70% have coded T93, 79% have hipertension, 38% are obese and 19% have TOD. The most frequent association of CVRF is HTA and T93 with 961 diabetics, followed by HTA with 373 diabetics.
The logistic regression model shows that CVRF in diabetic patients in association with CKD, there are two variables that have statistical significance (age and hypertension). So, a constant 1 year increment in age increases the chance of finding a patient with CKD by 10% and the chance of a diabetic patient having CKD while being hypertensive is 2.59 times higher than a normotensive diabetic patient.

Conclusions:
The presence of several CVRF is frequent in the population that was studied, and the identification and understanding of their distribution is essential for an adequate management of diabetes. CKD is a frequent complication in these patients, and regular evaluation of eGFR and the other CVRF is essential for proper therapeutic management.
PS-C12-8: BLOOD PRESSURE VARIABILITY IN PREVIOUSLY UNTREATED HYPERTENSIVE PATIENTS RANDOMIZED TO NIFEDIPINE GITS OR RAMIPRIL. REVERENT STUDY
Authors: Bilo Grzegorz , Kyriakoulis Konstantinos , Liu Chang Yuan , Soranna Davide , Ceravolo Isabella , Cassago Silvia , Zhang Wei , Kollias Anastasios , Pengo Martino F , Zambon Antonella , Wang Jiguang , Stergiou George S , Parati Gianfranco 
Published: January 2023

Blood pressure (BP) variability (BPV) independently predicts adverse outcomes, making it a potential target for treatment. Preliminary data indicate that dihydropyridine calcium channel blockers (CCB) may reduce BPV more than other antihypertensives.

Aim of Reverent:
(Reducing blood pressure Variability in Essential hypertension with Ramipril vErsus Nifedipine GITS) Trial was to compare changes in either short-, mid- and long-term BPV in patients treated with a CCB (nifedipine GITS) or an ACE inhibitor (ramipril) in a randomised fashion.

Methods:
Untreated (treatment-naïve or after treatment washout) patients with mild to moderate essential hypertension and elevated basal BPV, were randomized to open label treatment with nifedipine GITS 30 mg or ramipril 10 mg once daily. BPV after 10 weeks and 12 months of treatment was assessed based on home (primary endpoint; validated AND UA-651BLE monitor), 24-hour ambulatory (A&D TM 2430) and office (AND UA-651BLE) measurements and expressed as standard deviation [SD] of obtained readings.

Results:
156 patients were included in the intention-to-treat analysis of the main study (10 weeks, primary analysis) and 138 of the extension study (12 months, exploratory analysis). No significant differences were observed between groups at baseline. Patient characteristics, BP and BPV values after 10 weeks of treatment are reported in the table. No significant differences between groups were observed in home and office BPV at the end of main study, also after adjusting for mean BP reduction. 24-hour weighted SD of systolic BP after 10 weeks of treatment was lower in the nifedipine GITS group (p = 0.032). Exploratory analysis also revealed lower office BPV after 12 months of treatment in nifedipine GITS group (7.15 ± 3.79 vs 9.00 ± 5.28 mmHg, p = 0.026).

Conclusions:
The study did not identify differences between nifedipine GITS and ramipril in reducing home BPV, while significant differences in favour of nifedipine GITS were observed in 24-hour BPV and in office BPV after 12 months. Clinical impact of these findings remains to be evaluated in outcome studies.
PS-C14-7: THE PART OF HYPERTENSION IN HEART FAILURE IN NIGERIA
Authors: Musango Dennis Anthony , Onyeagala Augustine Anayo 
Published: January 2023

Objective:
The objective of this study was to determine the part of Hypertension among the heart failure causes in Nigeria.

Methods:
A total of 294 Patients with heart failure were selected. Between them 26 pacent (78) had Hypertension like origin of heart failure. The sex ratio was 0.73 and mean's age of Patients was 60years.

Results:
Thirty three cases of dyspnea and 31 cases respectively of class 3 and 4 New York Heart Association were observed. Global heart failure was found 45 cases and it concern left ventricular only 33 cases. Age 50 years, overweight and alcohol were most at risk factor noted. Clinical evaluation was favourable in the most of case. Also, we noted a death rate 5 percent and 7 percent re hospitalized in the year
PS-C15-10: ASSOCIATION OF BODY MASS INDEX, WAIST-TO-HEIGHT RATIO AND DURATION OF TYPE 2 DIABETES MELLITUS WITH DIABETIC RETINOPATHY IN WOMEN
Authors: Olatunji Victoria Ayodeji , Olarinoye John Kola , Arinde Olufemi William , Olatunji Lawrence Aderemi , Olorundare Olufunke Esan 
Published: January 2023

Objective:
Diabetic retinopathy (DR) is a common microvascular complication of diabetes mellitus (DM). It is a leading cause of visual impairment and blindness worldwide, reducing the quality of life of patients. Clear evidence of association between anthropometric measurements and DR risk is lacking in Nigerian females with type 2 DM (T2DM).

Design and Methods:
A cross-sectional study of 57 female participants with physician-diagnosed T2DM with or without systemic hypertension. Anthropometric measurements were taken. Fasting blood samples were drawn for laboratory analysis. All patients underwent dilated fundoscopy by a single Ophthalmologist and diabetic retinopathy was graded based on the worse eye.

Results:
The mean age of the participants was 60.8 ± 11.0 years with no significant age difference between the DR and Non-DR groups. Of the 57 participants, 36 had varying degrees of DR while 21 had no features of DR. Among the patients with DR, 26 were hypertensive diabetic while 10 were only diabetic. The hypertensive diabetic were older than the diabetic. The mean weight and body mass index (BMI) were higher in the non-DR group compared to the DR group. The DR group had significantly longer disease duration for both diabetes and hypertension. The hypertensive diabetic had significantly higher systolic blood pressure (SBP), pulse pressure (PP), total cholesterol-high density lipid ratio (TC:HDL) and serum triglyceride (TG) than the diabetic. BMI was negatively correlated with presence of DR, while weight, TyG-BMI, weight-height ratio (WHt), hip circumference (HC) and DM duration were positively correlated. BMI, WHt and TyG-BMI were negatively correlated with severity of DR while DM duration showed positive correlation.
Linear regression showed that the independent determinant of the presence of DR in hypertensive diabetic were WHt and DM duration, while for severity of DR, DM duration, neutrophil-lymphocyte ratio (NLR) and HbA1c status were predictors. When adjusted for DM duration, presence of DR was predicted by WHt while severity was predicted by BMI.
The curve of the receiver operating characteristic was also plotted to establish the relevance of each of the factors predicting DR and their area under the curve (AUC) was compared. The results showed that DM duration, HbA1c status, NLR, HTN duration, BMI, WHt were predictors.

Conclusions:
BMI, waist-to-height ratio and DM duration and neutrophil-to-lymphocyte ratio are associated with the occurrence and severity of DR in female hypertensive diabetic.
PS-C16-5: RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM INHIBITORS AND CLINICAL OUTCOMES IN COVID-19 PATIENTS WITH HYPERTENSION:A REPORT OF THREE PEAK WAVE PERIODS IN SEMARANG, INDONESIA
Authors: Karunawan Niyata Hananta , Jusuf Iin Irnawati , Tonang Alvin , Nugroho Prihatin Iman 
Published: January 2023

Objective:
We aimed to assess the association between RAAS inhibitors (ACEi or ARB) and the clinical outcomes of COVID-19 patients with hypertension in the First Wave, Second Wave and Third Wave at Secondary Referral Hospital, Indonesia

Methods:
This cross sectional study was based on an electronic medical record in the Dr Adhyatma MPH Tugurejo General Hospital, Semarang, Indonesia. All patients more than 18 years old who confirmed COVID-19 case in the first wave (November 2020 to January 2021), second wave (May 2021 to July 2021) and third wave (January 2022 to February 2022) were included in this study. Data about demographic, comorbidities, features of antihypertensive drugs and clinical outcomes were collected. The clinical outcomes included mortality and prolonged hospitalization (length of stay (LOS) > 10 days). The statistical measures calculated were Chi square test and Fischer's exact test.

Results:
From three periods of peak wave, data from 1560 COVID-19 patients was collected in the first wave (304;19.5%), the second wave (1038;66.5%), and the third wave (218;14.0%). Subjects were dominated by males (50.4%) and a median of age 50 (19 -91) years old. The common comorbidities in studies were diabetes mellitus with 318 (20.4%) and hypertension with 254 (16.3%). In the main analysis, 99 (39%) patients with hypertension receiving RAAS inhibitors were compared with 155 (61%) patients receiving other antihypertensive drugs. Our results showed that RAAS inhibitors was not associated with a higher risk of COVID-19 mortality (RR:1.01; 95% CI: 0.61–1.67; p:0.969) or prolonged LOS (RR:0.86; 95%CI: 0.60–1.26; p:0.408).

Conclusions:
In COVID-19 patients with hypertension, the use of RAAS inhibitors showed no increased mortality or prolonged LOS compared to patients without RAAS inhibitors. COVID-19 patients and patients exposed to the COVID-19 pandemic should not discontinue ACEi or ARBs.
PS-C16-14: EFFECT OF THE COVID-19 PANDEMIC ON AMBULATORY BLOOD PRESSURE MEASUREMENT
Authors: Nzokou Daryl Tcheutchoua , Chaumont Martin , Van de Borne Philippe 
Published: January 2023

Introduction:
The world is currently facing the fourth wave of the COVID-19 pandemic. The aim of this study is to assess the effect of this pandemic on ambulatory blood pressure measurements (ABPM) and to investigate the effect of SARS-CoV2 infection on blood pressure (BP).

Methods:
We conducted a uni-centric retrospective study on the ERASME hospital ABPM register, from 2010 to 2021. The nycthemeral blood pressure (BP) profile of the pandemic period (January 2020 to October 2021) was compared with that of the previous 5 control periods from January 2010 to October 2019. We also determined the diurnal, nocturnal and 24-hour high blood pressure frequencies for each period. Furthermore, for the COVID-19 period, the BP profiles of COVID-19 positive and negative patients were compared. Finally, in COVID-19 positive patients, we compared ABPMs performed before COVID-19 infection with those performed post-infection.

Results:
After excluding incomplete and poor-quality ABPM, 16,977 ABPMs were selected. The COVID-19 period accounted for 10.58% of ABPMs compared with 15–20% for pré-COVID periods. We observed that diurnal (83.20 vs 81.20; p < 0.001), nocturnal (73.02 vs 71.09; p < 0.001) and 24-hour (79.51 vs 77.50; p < 0.001) diastolic BPs were higher in the COVID-19 period. In contrast, diurnal (131.64 vs 133.18; p < 0.001), nocturnal (121.07 vs 121.93; p = 0.034) and 24-hour (127.82 vs 128.97; p < 0.001) systolic BPs were lower during the pandemic. In logistic regression, diastolic diurnal (OR:1.58 [1.33–1.89]; p < 0.001), nocturnal (OR:1.18 [1.02 - 1.36]; p = 0.026) and 24-hour (OR:1.22 [1.01 - 1.49]; p = 0.044) hypertension were associated with the COVID-19 period, when adjusted for age, gender or history of hypertension. Also, diurnal (OR:0.63 [0.55–0.71]; p < 0.001) and nocturnal (OR:0.82 [0.72–0.93]; p = 0.002) systolic hypertension were less frequent in the COVID-19 period. When comparing BPs between COVID-19 positive and negative patients, there was no significant difference. When ABPMs were compared before and after infection in COVID-19 positive patients, diastolic diurnal (88.41 vs. 78.88; p = 0.001), nocturnal (77.91 vs. 70.55; p = 0.027) and 24-hour (84.57 vs. 75.99; p = 0.002) BPs were higher after COVID-19 infection.

Conclusion:
Our study shows that during the COVID-19 pandemic, diastolic BP was higher and systolic BP was lower compared to the pre-COVID-19 period. We also observed an increase in diastolic BP after COVID-19 infection.