bluuebunny/crossref_metadata_2025_split huggingface dataset:
Strong Coupling Between Carbon Cycle, Climate, and Weathering During the Paleocene‐Eocene Thermal Maximum
Authors: Chen Zuoling , Ding Zhongli , Yang Shiling , Sun Jimin , Zhu Min , Xiao Yilin , Tong Fengtai , Liang Yao 
Published: May 2023

AbstractThe Paleocene‐Eocene Thermal Maximum (PETM; ∼56 Ma)–a geologically rapid carbon‐release event similar to anthropogenic carbon emissions–is ideal for investigating weathering responses to rapid carbon release and associated climate change. Here, for the first time, we present high‐resolution lacustrine lithium isotope data that reflect basin‐scale silicate weathering across the PETM in the Nanyang Basin, eastern China. Our results reveal an ∼100% increase in regional silicate weathering intensity through the PETM relative to the pre‐PETM level. Synchronous variations between carbon isotope values and weathering intensity demonstrate a strong coupling between carbon cycle, climate, and chemical weathering on millennial timescales. These findings argue that strong negative weathering feedback and massive removal of CO2 maintained Earth's climate within a habitable range during the PETM.
Eating behavior dimensions and 9-year weight loss maintenance: a sub-study of the Finnish Diabetes prevention study
Authors: Salmela Jutta , Konttinen Hanna , Lappalainen Raimo , Muotka Joona , Antikainen Anne , Lindström Jaana , Tuomilehto Jaakko , Uusitupa Matti , Karhunen Leila 
Published: May 2023

Abstract
Background
Behavioral processes through which lifestyle interventions influence risk factors for type 2 diabetes (T2DM), e.g., body weight, are not well-understood. We examined whether changes in psychological dimensions of eating behavior during the first year of lifestyle intervention would mediate the effects of intervention on body weight during a 9-year period.

Methods
Middle-aged participants (38 men, 60 women) with overweight and impaired glucose tolerance (IGT) were randomized to an intensive, individualized lifestyle intervention group (n = 51) or a control group (n = 47). At baseline and annually thereafter until nine years body weight was measured and the Three Factor Eating Questionnaire assessing cognitive restraint of eating with flexible and rigid components, disinhibition and susceptibility to hunger was completed. This was a sub-study of the Finnish Diabetes Prevention Study, conducted in Kuopio research center.

Results
During the first year of the intervention total cognitive (4.6 vs. 1.7 scores; p < 0.001), flexible (1.7 vs. 0.9; p = 0.018) and rigid (1.6 vs. 0.5; p = 0.001) restraint of eating increased, and body weight decreased (−5.2 vs. −1.2 kg; p < 0.001) more in the intervention group compared with the control group. The difference between the groups remained significant up to nine years regarding total (2.6 vs. 0.1 scores; p = 0.002) and rigid restraint (1.0 vs. 0.4; p = 0.004), and weight loss (−3.0 vs. 0.1 kg; p = 0.046). The first-year increases in total, flexible and rigid restraint statistically mediated the impact of intervention on weight loss during the 9-year study period.

Conclusions
Lifestyle intervention with intensive and individually tailored, professional counselling had long-lasting effects on cognitive restraint of eating and body weight in middle-aged participants with overweight and IGT. The mediation analyses suggest that early phase increase in cognitive restraint could have a role in long-term weight loss maintenance. This is important because long-term weight loss maintenance has various health benefits, including reduced risk of T2DM.
Different carbohydrate exposures and weight gain—results from a pooled analysis of three population-based studies
Authors: Tammi Rilla , Männistö Satu , Harald Kennet , Maukonen Mirkka , Eriksson Johan G. , Jousilahti Pekka , Koskinen Seppo , Kaartinen Niina E. 
Published: May 2023

Abstract
Background
The role of carbohydrate quantity and quality in weight gain remains unsolved, and research on carbohydrate subcategories is scarce. We examined total carbohydrates, dietary fiber, total sugar, and sucrose intake in relation to the risk of weight gain in Finnish adults.

Methods
Our data comprised 8327 adults aged 25−70 years in three population-based prospective cohorts. Diet was assessed by a validated food frequency questionnaire and nutrient intakes were calculated utilizing the Finnish Food Composition Database. Anthropometric measurements were collected according to standard protocols. Two-staged pooling was applied to derive relative risks across cohorts for weight gain of at least 5% by exposure variable intake quintiles in a 7-year follow-up. Linear trends were examined based on a Wald test.

Results
No association was observed between intakes of total carbohydrate, dietary fiber, total sugar or sucrose and the risk of weight gain of at least 5%. Yet, total sugar intake had a borderline protective association with the risk of weight gain in participants with obesity (RR 0.63; 95% CI 0.40−1.00 for highest vs. lowest quintile) and sucrose intake in participants with ≥10% decrease in carbohydrate intake during the follow-up (RR 0.78; 95% CI 0.61−1.00) after adjustments for sex, age, baseline weight, education, smoking, physical activity, and energy intake. Further adjustment for fruit consumption strengthened the associations.

Conclusions
Our findings do not support an association between carbohydrate intake and weight gain. However, the results suggested that concurrent changes in carbohydrate intake might be an important determinant of weight change and should be further examined in future studies.
Side effects of low-dose tamoxifen: results from a six-armed randomised controlled trial in healthy women
Authors: Hammarström Mattias , Gabrielson Marike , Crippa Alessio , Discacciati Andrea , Eklund Martin , Lundholm Cecilia , Bäcklund Magnus , Wengström Yvonne , Borgquist Signe , Bergqvist Jenny , Eriksson Mikael , Tapia José , Czene Kamila , Hall Per 
Published: May 2023

Abstract
Background
Adherence to adjuvant tamoxifen therapy is suboptimal, and acceptance of tamoxifen for primary prevention is poor. Published results indicate effect of low-dose tamoxifen therapy. Using questionnaire data from a randomised controlled trial, we describe side effects of standard and low-dose tamoxifen in healthy women.

Methods
In the KARISMA trial, 1440 healthy women were randomised to 6 months of daily intake of 20, 10, 5, 2.5, 1 mg of tamoxifen or placebo. Participants completed a 48-item, five-graded Likert score symptom questionnaire at baseline and follow-up. Linear regression models were used to identify significant changes in severity levels across doses and by menopausal status.

Results
Out of 48 predefined symptoms, five were associated with tamoxifen exposure (hot flashes, night sweats, cold sweats, vaginal discharge and muscle cramps). When comparing these side effects in premenopausal women randomised to low doses (2.5, 5 mg) versus high doses (10, 20 mg), the mean change was 34% lower in the low-dose group. No dose-dependent difference was seen in postmenopausal women.

Conclusions
Symptoms related to tamoxifen therapy are influenced by menopausal status. Low-dose tamoxifen, in contrast to high-dose, was associated with less pronounced side effects, a finding restricted to premenopausal women. Our findings give new insights which may influence future dosing strategies of tamoxifen in both the adjuvant and preventive settings.

Trial registration
ClinicalTrials.gov ID: NCT03346200.
N6-methyladenine-mediated aberrant activation of the lncRNA SOX2OT-GLI1 loop promotes non-small-cell lung cancer stemness
Authors: Dong Hongliang , Zeng Lili , Chen Weiwei , Zhang Qian , Wang Fei , Wu Yan , Cui Bingjie , Qi Jingjing , Zhang Xin , Liu Cuilan , Deng Jiong , Yu Yong , Schmitt Clemens A. , Du Jing 
Published: May 2023

AbstractDespite the advent of precision medicine and immunotherapy, mortality due to lung cancer remains high. The sonic hedgehog (SHH) cascade and its key terminal factor, glioma-associated oncogene homolog 1 (GLI1), play a pivotal role in the stemness and drug resistance of lung cancer. Here, we investigated the molecular mechanism of non-canonical aberrant GLI1 upregulation. The SHH cascade was upregulated in stem spheres and chemo-resistant lung cancer cells and was accountable for drug resistance against multiple chemotherapy regimens. GLI1 and the long non-coding RNA SOX2OT were positively regulated, and the GLI1-SOX2OT loop mediated the proliferation of parental and stem-like lung cancer cells. Further mechanistic investigation revealed that SOX2OT facilitated METTL3/14/IGF2BP2-mediated m6A modification and stabilization of the GLI1 mRNA. Additionally, SOX2OT upregulated METTL3/14/IGF2BP2 by sponging miR-186-5p. Functional analysis corroborated that GLI1 acted as a downstream target of METTL3/14/IGF2BP2, and GLI1 silencing could block the oncogenicity of lung cancer stem-like cells. Pharmacological inhibition of the loop remarkably inhibited the oncogenesis of lung cancer cells in vivo. Compared with paired adjacent normal tissues, lung cancer specimens exhibited consistently upregulated GLI1/SOX2OT/METTL3/14/IGF2BP2. The m6A-modified GLI1-SOX2OT loop may serve as a potential therapeutic target and prognostic predictor for lung cancer therapy and diagnosis in the clinic.
B7-H3 specific CAR-T cells exhibit potent activity against prostate cancer
Authors: Li Shibao , Zhang Miaomiao , Wang Meng , Wang Haiting , Wu Han , Mao Lijun , Zhang Meng , Li Huizhong , Zheng Junnian , Ma Ping , Wang Gang 
Published: May 2023

AbstractB7-H3 is an attractive target for immunotherapy because of its high expression across multiple solid tumors, including prostate cancer, and restricted expression in normal tissues. Among various types of tumor immunotherapy, chimeric antigen receptor T (CAR-T) cell therapy has shown remarkable success in hematological tumors. However, the potency of CAR-T cell therapy in solid tumors is still limited. Here, we examined the expression of B7-H3 in prostate cancer tissues and cells and developed a second-generation CAR that specifically targets B7-H3 and CD28 as costimulatory receptor to explore its tumoricidal potential against prostate cancer in vitro and in vivo. The high expression of B7-H3 was detected on both the surface of PC3, DU145 and LNCaP cells and prostate cancer tissues. B7-H3 CAR-T cells efficiently controlled the growth of prostate cancer in an antigen-dependent manner in vitro and in vivo. Moreover, tumor cells could induce the proliferation of CAR-T cells and the release of high levels of cytokines of IFN-γ and TNF-α in vitro. Results demonstrated that B7-H3 is a potential target for prostate cancer therapy that supports the clinical development of B7-H3 specific CAR-T cells for prostate cancer.
Structured transverse orbital angular momentum probed by a levitated optomechanical sensor
Authors: Hu Yanhui , Kingsley-Smith Jack J. , Nikkhou Maryam , Sabin James A. , Rodríguez-Fortuño Francisco J. , Xu Xiaohao , Millen James 
Published: May 2023

AbstractThe momentum carried by structured light fields exhibits a rich array of surprising features. In this work, we generatetransverseorbital angular momentum (TOAM) in the interference field of two parallel and counter-propagating linearly-polarised focused beams, synthesising an array of identical handedness vortices carrying intrinsic TOAM. We explore this structured light field using an optomechanical sensor, consisting of an optically levitated silicon nanorod, whose rotation is a probe of the optical angular momentum, which generates an exceptionally large torque. This simple creation and direct observation of TOAM will have applications in studies of fundamental physics, the optical manipulation of matter and quantum optomechanics.
Interplay between copper redox and transfer and support acidity and topology in low temperature NH3-SCR
Authors: Wu Yiqing , Zhao Wenru , Ahn Sang Hyun , Wang Yilin , Walter Eric D. , Chen Ying , Derewinski Miroslaw A. , Washton Nancy M. , Rappé Kenneth G. , Wang Yong , Mei Donghai , Hong Suk Bong , Gao Feng 
Published: May 2023

AbstractLow-temperature standard NH3-SCR over copper-exchanged zeolite catalysts occurs on NH3-solvated Cu-ion active sites in a quasi-homogeneous manner. As key kinetically relevant reaction steps, the reaction intermediate CuII(NH3)4ion hydrolyzes to CuII(OH)(NH3)3ion to gain redox activity. The CuII(OH)(NH3)3ion also transfers between neighboring zeolite cages to form highly reactive reaction intermediates. Viaoperandoelectron paramagnetic resonance spectroscopy and SCR kinetic measurements and density functional theory calculations, we demonstrate here that such kinetically relevant steps become energetically more difficult with lower support Brønsted acid strength and density. Consequently, Cu/LTA displays lower Cu atomic efficiency than Cu/CHA and Cu/AEI, which can also be rationalized by considering differences in their support topology. By carrying out hydrothermal aging to eliminate support Brønsted acid sites, both CuII(NH3)4ion hydrolysis and CuII(OH)(NH3)3ion migration are hindered, leading to a marked decrease in Cu atomic efficiency for all catalysts.
Selective conversion of CO2 to isobutane-enriched C4 alkanes over InZrOx-Beta composite catalyst
Authors: Wang Han , Fan Sheng , Guo Shujia , Wang Sen , Qin Zhangfeng , Dong Mei , Zhu Huaqing , Fan Weibin , Wang Jianguo 
Published: May 2023

AbstractDirect conversion of CO2 to a single specific hydrocarbon with high selectivity is extremely attractive but very challenging. Herein, by employing an InZrOx-Beta composite catalyst in the CO2 hydrogenation, a high selectivity of 53.4% to butane is achieved in hydrocarbons (CO free) under 315 °C and 3.0 MPa, at a CO2 conversion of 20.4%. Various characterizations and DFT calculation reveal that the generation of methanol-related intermediates by CO2 hydrogenation is closely related to the surface oxygen vacancies of InZrOx, which can be tuned through modulating the preparation methods. In contrast, the three-dimensional 12-ring channels of H-Beta conduces to forming higher methylbenzenes and methylnaphthalenes containing isopropyl side-chain, which favors the transformation of methanol-related intermediates to butane through alkyl side-chain elimination and subsequent methylation and hydrogenation. Moreover, the catalytic stability of InZrOx-Beta in the CO2 hydrogenation is considerably improved by a surface silica protection strategy which can effectively inhibit the indium migration.
China can be self-sufficient in maize production by 2030 with optimal crop management
Authors: Luo Ning , Meng Qingfeng , Feng Puyu , Qu Ziren , Yu Yonghong , Liu De Li , Müller Christoph , Wang Pu 
Published: May 2023

AbstractPopulation growth and economic development in China has increased the demand for food and animal feed, raising questions regarding China’s future maize production self-sufficiency. Here, we address this challenge by combining data-driven projections with a machine learning method on data from 402 stations, with data from 87 field experiments across China. Current maize yield would be roughly doubled with the implementation of optimal planting density and management. In the 2030 s, we estimate a 52% yield improvement through dense planting and soil improvement under a high-end climate forcing Shared Socio-Economic Pathway (SSP585), compared with a historical climate trend. Based on our results, yield gains from soil improvement outweigh the adverse effects of climate change. This implies that China can be self-sufficient in maize by using current cropping areas. Our results challenge the view of yield stagnation in most global areas and provide an example of how food security can be achieved with optimal crop-soil management under future climate change scenarios.
Optimal entanglement distribution policies in homogeneous repeater chains with cutoffs
Authors: Iñesta Álvaro G. , Vardoyan Gayane , Scavuzzo Lara , Wehner Stephanie 
Published: May 2023

AbstractWe study the limits of bipartite entanglement distribution using a chain of quantum repeaters that have quantum memories. To generate end-to-end entanglement, each node can attempt the generation of an entangled link with a neighbor, or perform an entanglement swapping measurement. A maximum storage time, known as cutoff, is enforced on the memories to ensure high-quality entanglement. Nodes follow a policy that determines when to perform each operation. Global-knowledge policies take into account all the information about the entanglement already produced. Here, we find global-knowledge policies that minimize the expected time to produce end-to-end entanglement. Our methods are based on Markov decision processes and value and policy iteration. We compare optimal policies to a policy in which nodes only use local information. We find that the advantage in expected delivery time provided by an optimal global-knowledge policy increases with increasing number of nodes and decreasing probability of successful swapping.
Robust three-dimensional type-II Dirac semimetal state in SrAgBi
Authors: Hu Zhixiang , Deng Junze , Li Hang , Ogunbunmi Michael O. , Tong Xiao , Wang Qi , Graf David , Pudełko Wojciech Radoslaw , Liu Yu , Lei Hechang , Bobev Svilen , Radovic Milan , Wang Zhijun , Petrovic Cedomir 
Published: May 2023

AbstractTopological semimetals such as Dirac, Weyl or nodal line semimetals are widely studied for their peculiar properties including high Fermi velocities, small effective masses and high magnetoresistance. When the Dirac cone is tilted, exotic phenomena could emerge whereas materials hosting such states are promising for photonics and plasmonics applications. Here we present evidence that SrAgBi is a spin-orbit coupling-induced type-II three-dimensional Dirac semimetal featuring tilted Dirac cone at the Fermi energy. Near charge compensation and Fermi surface characteristics are not much perturbed by 7% of vacancy defects on the Ag atomic site, suggesting that SrAgBi could be a material of interest for observation of robust optical and spintronic topological quantum phenomena.
Tissue-like cultured fish fillets through a synthetic food pipeline
Authors: Xu Enbo , Niu Ruihao , Lao Jihui , Zhang Shengliang , Li Jie , Zhu Yiyuan , Shi Huimin , Zhu Qingqing , Chen Yijian , Jiang Yuyan , Wang Wenjun , Yin Jun , Chen Qihe , Huang Xiao , Chen Jun , Liu Donghong 
Published: May 2023

AbstractTissue-like cultured meats of some livestock have successfully been established by different approaches. However, the production of a structure similar to fish fillets is still challenging. Here, we develop tissue-like cultured fish fillets by assembly of large yellow croaker muscle fibers and adipocytes with 3D-printed gel. Inhibition of Tgf-β and Notch signals significantly promoted myogenic differentiation of piscine satellite cells (PSCs). The mixture of fish gelatin and sodium alginate combined with a p53 inhibitor and a Yap activator supported PSC viability and proliferation. Based on the texture of fish muscle tissue, a 3D scaffold was constructed by gelatin-based gel mixed with PSCs. After proliferation and differentiation, the muscle scaffold was filled with cultured piscine adipocytes. Finally, tissue-like fish fillets with 20 × 12 × 4 mm were formed, consisting of 5.67 × 107 muscles and 4.02 × 107 adipocytes. The biomanufacture of tissue-like cultured fish fillet here could be a promising technology to customize meat production with high fidelity.
Inter-basin surface water transfers database for public water supplies in conterminous United States, 1986–2015
Authors: Dobbs G. Rebecca , Liu Ning , Caldwell Peter V. , Miniat Chelcy Ford , Sun Ge , Duan Kai , Bolstad Paul V. 
Published: May 2023

AbstractThe manipulation of water resources is a common human solution to water-related problems. Of particular interest because of impacts on both source and destination is the anthropogenic movement of water from one basin to another, or inter-basin transfers (IBTs). In the United States, IBTs occur widely in both wet and dry regions, but IBT data are not collated and served in a coordinated way. Thus researchers wishing to account for transfers between basins have faced difficulty in doing so. Here we present the outcome of a systematic investigation into inter-basin surface water transfers connected with public water supplies in the conterminous United States (CONUS), 1986 to 2015. The present open-access geodatabase includes transfer volumes collected, evaluated, and compiled from disparate sources. We provide an updated snapshot of CONUS IBTs at a higher spatial resolution of points of withdrawal and delivery than previous datasets. This paper puts the national inter-basin transfer data in context, and shows how we acquired, structured, and validated the locations and volumes of surface water transfers in public water systems.
A 10-km CMIP6 downscaled dataset of temperature and precipitation for historical and future Vietnam climate
Authors: Tran-Anh Quan , Ngo-Duc Thanh , Espagne Etienne , Trinh-Tuan Long 
Published: May 2023

AbstractHigh-resolution climate projections are mandatory for many applications and impact assessments in environmental and management studies. In response to the needs in Vietnam, this study constructs a new precipitation and temperature daily dataset for Vietnam, at a high spatial resolution of 0.1° × 0.1°, based on the outputs of 35 global climate models (GCMs) from the Coupled Model Intercomparison Project Phase 6 (CMIP6). The Bias Correction and Spatial Disaggregation (BCSD) method is adopted to bias-correct monthly GCM simulations using observation data, then subsequently temporally disaggregate them into daily data. The new dataset is called CMIP6-VN, covering the present-time period 1980–2014 and future projections for 2015–2099 from both CMIP6 tier-1 (Shared Socioeconomic Pathways (SSPs) 1–1.26, 2–4.5, 3–7.0, and 5–8.5) and tier-2 (SSPs 1–1.9, 4–3.4, 4–6.0) experiments. Results indicated the good performance of CMIP6-VN for the historical period, suggesting that the dataset could be used for studies on climate change assessment and impacts in Vietnam.