bluuebunny/crossref_metadata_2025_split huggingface dataset:
Observation of enhanced activity of the 178m2Hf isomeric target after its irradiation by bremsstrahlung radiation
Authors: Kirischuk Vladimir 
Published: July 2023

Abstract
Comparing the spectra acquired during two series of irradiations, the peak intensities of the 178m2Hf isomer have been found to be higher at the end of each series, while the intensities of the 150Eu and 133Ba peaks, which are present in the isomeric target, remain stable. This gives a support to the hypothesis that some additional activity is produced during irradiation. The half-life of this activity appears to be several days.
Association of Blood Pressure With Cardio-Renal Events and Mortality in Type 2 DM: A National Health Insurance Database
Authors: Kim Bo-Yeon , Lee Ji-In , Lee Hye-Mi , Kim So Hun , Mo Eun Yeong , Son Jang Won , Lee Sihoon , Kim Sungrae 
Published: July 2023

Abstract

Context
The relationship of blood pressure (BP) with cardio-renal events and all-cause mortality in type 2 diabetes mellitus (T2DM) is still controversial.

Objective
To investigate the optimal BP target in Korean individuals with T2DM.

Methods
Using the Korean National Health Insurance System database, data of individuals with T2DM who underwent regular health checks from January 1, 2007, to December 31, 2007, were extracted (N = 1 800 073). Among them, a total of 326 593 individuals were included in the final study. The study population was divided into 7 groups according to their observed systolic blood pressure (SBP) (&lt;110, 110-119, 120-129, 130-139, 140-149, 150-159, 160-169, and ≥170 mmHg) and diastolic blood pressure (DBP) (&lt;65, 65-69, 70-74, 75-79, 80-84, 85-89, and ≥90 mmHg). Hazard ratios (HRs) of cardio-renal events and all-cause mortality according to BP categories were analyzed.

Results
Compared with SBP of 120-129 mmHg and DBP of 75-79 mmHg, SBP of ≥130 mmHg and DBP of ≥ 80 mmHg were associated with an increase in HR of major cardiovascular adverse events (MACEs). SBP of 120-129 mmHg and DBP 75-79 mmHg were associated with the lowest HR of all-cause mortality. Both lower BP (SBP/DBP &lt;120/70 mm) and higher BP (SBP/DBP ≥130/80 mmHg) were associated with an increased HR of all-cause mortality. Contrary to MACE, the lower the SBP, the lower the HR of renal events.

Conclusion
In patients with T2DM, the optimal cutoff value of BP associated with a lower incidence of MACE and mortality may be 120-129 mmHg for SBP and 75-79 mmHg for DBP. However, lower SBP may be helpful for T2DM patients with a high risk of renal disease.
Diagnosis, Genetics, and Management of 24 Patients With Cardiac Paragangliomas: Experience From a Single Center
Authors: Shi Chuan , Liu Jian-Zhou , Zeng Zheng-Pei , Miao Qi , Fang Li-Gang , Chen Shi , Ping Fan , Sun Hao , Lu Lin , Chen Li-Bo , Fu Yong , Zhao Da-Chun , Yu Chun-Hua , JiaJue Rui-Zhi , Wang Xi , Liu Xing-Rong , Ma Guo-Tao , Zhang Chao-Ji , Pan Hui , Yang Hong-Bo , Wang Yi-Ning , Li Ming , Li Fang , Shen Zhu-Jun , Liang Zhi-Yong , Xing Xiao-Ping , Zhu Wen-Ling 
Published: July 2023

Abstract

Context
Paragangliomas located within the pericardium represent a rare yet challenging clinical situation.

Objective
The current analysis aimed to describe the clinical characteristics of cardiac paragangliomas, with emphasis on the diagnostic approach, genetic background, and multidisciplinary management.

Methods
Twenty-four patients diagnosed with cardiac paraganglioma (PGL) in Peking Union Medical College Hospital, Beijing, China, between 2003 and 2021 were identified. Clinical data was collected from medical record. Genetic screening and succinate dehydrogenase subunit B immunohistochemistry were performed in 22 patients.

Results
The median age at diagnosis was 38 years (range 11-51 years), 8 patients (33%) were females, and 4 (17%) had familial history. Hypertension and/or symptoms related to catecholamine secretion were present in 22 (92%) patients. Excess levels of catecholamines and/or metanephrines were detected in 22 (96%) of the 23 patients who have completed biochemical testing. Cardiac PGLs were localized with 131I-metaiodobenzylguanidine scintigraphy in 11/22 (50%), and 99mTc-hydrazinonicotinyl-tyr3-octreotide scintigraphy in 24/24 (100%) patients. Genetic testing identified germline SDHx mutations in 13/22 (59%) patients, while immunohistochemistry revealed succinate dehydrogenase (SDH) deficiency in tumors from 17/22 (77%) patients. All patients were managed by a multidisciplinary team through medical preparation, surgery, and follow-up. Twenty-three patients received surgical treatment and perioperative death occurred in 2 cases. Overall, 21 patients were alive at follow-up (median 7.0 years, range 0.6-18 years). Local recurrence or metastasis developed in 3 patients, all of whom had SDH-deficient tumors.

Conclusion
Cardiac PGLs can be diagnosed based on clinical manifestations, biochemical tests, and appropriate imaging studies. Genetic screening, multidisciplinary approach, and long-term follow-up are crucial in the management of this disease.
Analysis of factors affecting intraoperative conversion from thoracoscopic radical resection of lung cancer to thoracotomy and intraoperative management experience
Authors: Zhang Zhen , Zhang Yuefeng , Zhang Jian , Su Peng 
Published: July 2023

Objective: To explore the factors affecting the intraoperative conversion of video-assisted thoracoscopic surgery (VATS) to thoracotomy in patients with lung cancer.
Methods: The clinical data of 80 patients with lung cancer in The Fourth Hospital of Hebei Medical University from May 2019 to December 2021 were retrospectively analyzed. The patients who were treated with VATS alone were included into thoracoscopy group (n= 40), and those who were intraoperatively converted from VATS to thoracotomy were included into conversion group (n= 40). The medical record data were collected, the influencing factors of intraoperative conversion from VATS to thoracotomy were analyzed, and the surgical indexes and postoperative complications were compared between the two groups.
Results: Multivariate regression model showed that tumor in the upper lobe, central lung cancer, history of pulmonary tuberculosis, pleural adhesion ≥ Grade-4 and maximum tumor diameter ≥ 35 mm were risk factors for patients with lung cancer undergoing conversion from VATS to thoracotomy (p< 0.05). In the conversion group, the surgical duration and hospital stay were longer, the intraoperative bleeding volume and thoracic drainage volume were larger, and the total incidence of postoperative complications was higher than those in the thoracoscopy group (p< 0.05).
Conclusion: Conversion from VATS to thoracotomy may increase the risk of complications in patients with lung cancer. Tumor in the upper lobe, central lung cancer, history of pulmonary tuberculosis, high degree of pleural adhesion and large tumor diameter are risk factors for conversion from VATS to thoracotomy.
doi: https://doi.org/10.12669/pjms.39.5.7422
How to cite this: Zhang Z, Zhang Y, Zhang J, Su P. Analysis of factors affecting intraoperative conversion from thoracoscopic radical resection of lung cancer to thoracotomy and intraoperative management experience. Pak J Med Sci. 2023;39(5):---------. doi: https://doi.org/10.12669/pjms.39.5.7422
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Bioconversion of biowaste by black soldier fly larvae (Hermetia illucens L.) for dried larvae production: A life cycle assessment and environmental impact analysis
Authors: Nugroho Rudy Agung , Rofiq Muhammad Nasir , Santoso Arif Dwi , Yanuar Ahmad Ismed , Hanifa Rahmania , Nadirah Nadirah 
Published: July 2023

Background: Hermetia illucens L. have gained popularity in recent years as an environmentally friendly response to both the present and potential future food/feed crisis. The larvae of H. illucens L., or black soldier fly larvae (BSFL), is an alternative solution to tackle the issue of organic waste bioconversion. However, understanding the environmental loads associated with biowaste bioconversion using BSFL to produce dried BSFL is a pivotal point to keep the environment sustainable. This study reported a life cycle assessment (LCA) of the biowaste bioconversion process of BSFL and determined the environment impact analysis to make recommendations for modifications to lessen environmental consequences. Methods: The methodology used is life cycle assessment (LCA), which includes: (a) system boundary determination (gate-to-gate), starting from biowaste production, biowaste bioconversion, prepupae and BSFL frass production. The system boundary of the dried BSFL production is designed for both the processing and production of one cycle of BSFL; (b) life cycle inventory activities carried out at PT Biomagg Sinergi Internasional, Depok, West Java, Indonesia; (c) conducting life cycle impact assessment on five environmental impact categories namely global warming potential (GWP), acidification (AC), terrestrial eutrophication (TE), fossil fuel depletion (FFE), eco-toxicity (ET); and (d) interpretation of the assessment result. The LCA is conducted using openLCA 1.11 software and TRACI 2.1 impact assessment method. Results: The impact values of GWP, AC, TE, FFE, and ET, per 100 kg of BSFL dried production was 6.687 kg CO2 eq; 0.029 kg SO2-eq; 0.092 kg N-eq; 16.732 MJ surplus; 121.231 CTUe. Production of prepupa had the highest hotspots in these emissions, followed dried BSFL production. Conclusions: Efforts to reduce environmental impacts that can be done are by implementing an integrated rearing system using substrate from a single type of known substrate for BSFL and using alternative drying methods for BSFL dried production.
Finding presence during a pandemic: a qualitative analysis of participation in an Irish University online mindfulness practice during the COVID-19 emergency
Authors: Flynn Eva , Salmon Niamh , O’Keeffe Derek , Hassed Craig 
Published: July 2023

Background: In response to the change, and distress, that many faced during the time of the COVID-19 pandemic, a twice weekly online practice of mindfulness meditation was delivered to staff, students and the wider community outside of the University of Galway, Ireland. Mindfulness is a contemplative practice which improves coping skills and reduces emotional distress. This practice allows attention to be directed to the present moment, with acceptance and without judgement. Strengthening this practice nurtures skills of dealing with difficult emotions, changing unhelpful habits, behaviours and strengthening resilience during uncertainty. The twice weekly practice of an online mindfulness meditation was delivered in the context of the changes and preventative measures of the first pandemic lockdown in Ireland. The main objective of this practice is to cultivate skills of returning to the present, being grounded and building resilience amidst adversity. The aim of this study is to examine the effect of the offered regular online practice of mindfulness meditation for participants during the COVID-19 emergency, exploring through qualitative analysis of their own lived experience with this intervention. Methods: This qualitative study consisted of a short-structured interview process to explore the participants’ experience of the online practice of mindfulness during the COVID-19 pandemic. Results: From participating in this regular practice at this time, participants reported improved self-awareness, stress management and emotional regulation. Along with this, participants reported the felt sense of empathy and compassion and a sense of connection. Conclusion: This study has shown that during the difficult time of the COVID-19 pandemic, an online mindfulness meditation led to better wellbeing.
ediblecity: an R package to model and estimate the benefits of urban agriculture
Authors: Pueyo-Ros Josep , Comas Joaquim , Corominas Lluís 
Published: July 2023

Urban agriculture is gaining attraction to become one of the pillars of the urban ecological transition and to increase food security in an urbanized planet. However, there is a lack of systematic quantification of the benefits provided by urban agriculture solutions. In this paper, we present an R package to estimate several indicators related to benefits of urban agriculture. The goal is to provide a tool for researchers and practitioners interested in the impacts of urban agriculture. The ediblecity package provides functions to calculate 8 indicators: urban heat island, runoff prevention, green areas accessibility, NO2 sequestration, jobs created in commercial gardens, volunteers involved in community gardens, green per capita and, finally, food production. Moreover, the package also provides a function to generate scenarios with different implementations of urban agriculture. We illustrate the use of the package by comparing three scenarios in a neighborhood of Girona (Spain), which is included in the package as an example dataset. There, we compare scenarios with an increasing amount of urban agriculture solutions. The ediblecity package is open-source software. This allows other R developers to contribute to the package, providing new functionalities or improving the existing ones.
Assessing the impact of COVID-19 on STEM (science, technology, engineering, mathematics) researchers in India
Authors: Mehta Nikita , Inamdar Vedika , Puthillam Arathy , Chunekar Shivani , Kapoor Hansika , Tagat Anirudh , Subramanyam Deepa 
Published: July 2023

Background: The coronavirus disease 2019 (COVID-19) pandemic and the nationally mandated lockdown has resulted in facility closures, decreased laboratory activities, and shifting to remote working. The effects of the pandemic have spread across all professions, including academia. Hence, the present study aims to understand the extent of the impact of the COVID-19 pandemic on STEM (science, technology, engineering, mathematics) researchers and stakeholders in India. Methods: The study employed a mixed method design. Both quantitative (survey) and qualitative (interview) methods were used to gain a comprehensive understanding on the impact of the COVID-19 pandemic on STEM (science, technology, engineering, mathematics) early career researchers (ECRs), graduate students, Heads of Institutes, suppliers of scientific equipment, funders, and other stakeholders in India. Results: A total of 618 researchers completed the survey, and 24 stakeholders were interviewed for this study. Our findings highlight the importance of institutional and social support for mental well-being and scientific productivity among researchers, especially during the pandemic. It also shows the impact of the disruptions in grant disbursals on research activities of scientists. Further, the gendered impact between these relationships was also noted, all of which hint at a need for structured reform within STEM. Conclusions: The study highlights the various challenges faced by early career researchers, and STEM scientists at various positions in their careers during the COVID-19 restrictions in India.
Strategic Implications of Online Retail Platforms’ Membership-Based Free Shipping Programs
Authors: Sun Geng , Cavusoglu Huseyin , Raghunathan Srinivasan 
Published: July 2023

Product shipping is an indispensable but costly operation in online retailing. Although several initiatives are underway to reduce the shipping cost, an important innovation is the membership-based free shipping (MFS) program, in which a retail platform that allows third-party sellers to sell their products for a commission bears the shipping costs for purchases made by members who have paid an up-front fee. We identify several strategic impacts of MFS programs that are the key drivers to their success from the platform’s or other stakeholders’ perspectives. For example, we find that the membership fee collected by the platform does not cover its shipping cost, which suggests the MFS program benefits members and hurts the platform if the program is evaluated based on direct operational considerations only. However, we also show that the MFS program actually benefits the platform and hurts consumers when the shipping cost is less than a threshold. Moreover, the platform’s benefit from the MFS program follows an inverted U shape with respect to the shipping cost, suggesting that the program enjoys the greatest benefit for products with a moderate shipping cost. Even though the MFS program enhances the overall consumer demand and consumption, it could hurt society because the MFS program stimulates demand from consumers who have a low consumption utility relative to the shipping cost. Our results demonstrate that the MFS program is not just a shipping cost-transfer mechanism; rather, it is a strategic initiative by online retail platforms to exploit the need for product shipping to their advantage. History: Ram Gopal, Senior Editor; Yuliang Yao, Associate Editor. Supplemental Material: The online supplement is available at https://doi.org/10.1287/isre.2022.0208 .
ANÁLISE TECTÔNICA NA REDE DE DRENAGEM DA MANTIQUEIRA MERIDIONAL E SETENTRIONAL (MG)
Authors: Silva Felipe Pacheco 
Published: July 2023

A abordagem dessa pesquisa tem como base as propostas metodológicas em geomorfologia tectônica, presente nos trabalhos desenvolvidos por Keller e Pinter (1996). A geomorfologia tectônica busca elucidar aspectos da história geológica das paisagens terrestres e como os processos tectônicos exerceram influência na emolduração do relevo. Diante disso, o objetivo dessa pesquisa é identificar os esforços tectônicos na rede de drenagem da Serra da Mantiqueira e avaliar as implicações neotectônicas na rede de drenagem da Mantiqueira Meridional e Setentrional. Selecionou-se a bacia do rio Caparaó (Mantiqueira Setentrional) e a bacia do rio Bananal (Mantiqueira Meridional) para investigação e aplicação de três índices geomorfométricos: Fator de Simetria Transverso – T (COX, 1994), Integral e Curva Hipsométrica – IH (KELLER e PINTER, 1996) e Assimetria de Bacia de Drenagem – AF (HARE e GARDNER, 1985). De modo geral, as bacias selecionadas apresentam uma distinta configuração da rede de drenagem, sendo constatado uma menor assimetria na bacia do rio Caparaó, a qual apresentou deformações pontuais na rede de drenagem para o índice T; em contrapartida, a bacia hidrográfica do rio Bananal apresentou um conjunto de anomalias e assimetrias mais contundentes a um quadro de deformações mais recentes, reunindo elevados valores de T e Af. Neste contexto, foi possível registrar como a drenagem do segmento Meridional da Serra da Mantiqueira possuí fortes elos com os esforços oriundos da reativação tectônica mesozoico-cenozoica.
A metáfora das redes na formação docente: enredando e (redes)cobrindo
Authors: Pinheiro Laís Lemos Silva Novo , Fontoura Helena Amaral da 
Published: July 2023

O presente artigo tem por objetivo desenvolver a ideia, até então embrionária, escrita sob a forma de um resumo expandido a partir da metáfora das redes para o XI Seminário Internacional As Redes Educativas e as Tecnologias – Docentes na resistência e na criação, evento este popularmente chamado de Redes. Assim, a relação estabelecida entre a metáfora das redes e o evento Redes (2022) justificou o jogo de palavras que intitulou o referido resumo expandido: “Redes no Redes: enredando metáforas de formação docente” e que, agora, segue se entrelaçando nas linhas do presente texto. A essência do primeiro escrito permanece e ganha novos contornos, despertando a compreensão dos processos de formação docente pelo viés metafórico, adentrando o campo das narrativas e colaborando para construções semânticas na área educacional. Para tanto, enredada nos fios teóricos de Josso, Gatti, Nóvoa, Autora 1, Autora 2, Huberman e Marcelo, esta narrativa pretende retomar e dar continuidade ao estudo metafórico já iniciado, além de inspirar e gerar novas conexões acerca dos processos de formação docente.
Educação e surdez: a língua escrita como instrumento de exclusão social
Authors: Lima Ezer Wellington Gomes 
Published: July 2023

O texto aqui desenhado ressalta a importância de se pensar em uma educação que esteja totalmente imersa nas diferentes vivências do espaço escolar, com destaque para os inúmeros aspectos relacionados à representação da escrita. Por meio de um estudo teórico-conceitual, com caráter exploratório, por centrar-se na (re)construção de conceitos, ideias e ideologias necessários ao aprimoramento dos fundamentos teóricos já desenvolvidos sobre a temática. Deste modo, optou-se por autores que contribuíram diretamente para o desdobramento do tema citado, quais sejam: Senna (2010), Auroux (1992), Delacampagne (1995), dentre outros. Objetivou-se, então, avançar na análise de aspectos relativos às práticas escolares, com ênfase no processo de aquisição da língua escrita por educandos surdos. Tal investigação se justifica pela necessidade de analisar questões de ordem linguística, pois inclui também aspectos socioculturais. Entretanto, a predominância da Língua Portuguesa como instrumento de poder e canal único de conhecimento ultrapassa e se contrapõe às determinações legais que fortalecem o reconhecimento da língua de sinais em âmbito nacional. Os resultados deste estudo sinalizam que, no contexto escolar, muitos alunos surdos são prejudicados pela falta de estímulos adequados ao seu potencial cognitivo, sócio afetivo, linguístico e político-cultural, passando a ter perdas consideráveis no desenvolvimento da aprendizagem. Diante destas constatações, destaca-se a necessidade de se (re)pensar os métodos e/ou estratégias mais adequadas ao ensino da gramática da Língua Portuguesa para surdos, levando em conta os desafios e possiblidades de cada aprendiz.
Characterization of the alternative splicing landscape in lung adenocarcinoma reveals novel prognosis signature associated with B cells
Authors: Shao Ming-Ming , Zhai Kan , Huang Zhong-Yin , Yi Feng-Shuang , Zheng Sheng-Cai , Liu Ya-Lan , Qiao Xin , Chen Qing-Yu , Wang Zhen , Shi Huan-Zhong 
Published: July 2023

Background
Lung cancer is the second most commonly diagnosed cancer and the leading cause of cancer-related death. Malignant pleural effusion (MPE) is a special microenvironment for lung cancer metastasis. Alternative splicing, which is regulated by splicing factors, affects the expression of most genes and influences carcinogenesis and metastasis.

Methods
mRNA-seq data and alternative splicing events in lung adenocarcinoma (LUAD) were obtained from The Cancer Genome Atlas (TCGA). A risk model was generated by Cox regression analyses and LASSO regression. Cell isolation and flow cytometry were used to identify B cells.

Results
We systematically analyzed the splicing factors, alternative splicing events, clinical characteristics, and immunologic features of LUAD in the TCGA cohort. A risk signature based on 23 alternative splicing events was established and identified as an independent prognosis factor in LUAD. Among all patients, the risk signature showed a better prognostic value in metastatic patients. By single-sample gene set enrichment analysis, we found that among tumor-infiltrating lymphocytes, B cells were most significantly correlated to the risk score. Furthermore, we investigated the classification and function of B cells in MPE, a metastatic microenvironment of LUAD, and found that regulatory B cells might participate in the regulation of the immune microenvironment of MPE through antigen presentation and promotion of regulatory T cell differentiation.

Conclusions
We evaluated the prognostic value of alternative splicing events in LUAD and metastatic LUAD. We found that regulatory B cells had the function of antigen presentation, inhibited naïve T cells from differentiating into Th1 cells, and promoted Treg differentiation in LUAD patients with MPE.