bluuebunny/crossref_metadata_2025_split huggingface dataset:
Blue organic light-emitting diode with a turn-on voltage of 1.47 V
Authors: Izawa Seiichiro , Morimoto Masahiro , Fujimoto Keisuke , Banno Koki , Majima Yutaka , Takahashi Masaki , Naka Shigeki , Hiramoto Masahiro 
Published: September 2023

AbstractAmong the three primary colors, blue emission in organic light-emitting diodes (OLEDs) are highly important but very difficult to develop. OLEDs have already been commercialized; however, blue OLEDs have the problem of requiring a high applied voltage due to the high-energy of blue emission. Herein, an ultralow voltage turn-on at 1.47 V for blue emission with a peak wavelength at 462 nm (2.68 eV) is demonstrated in an OLED device with a typical blue-fluorescent emitter that is widely utilized in a commercial display. This OLED reaches 100 cd/m2, which is equivalent to the luminance of a typical commercial display, at 1.97 V. Blue emission from the OLED is achieved by the selective excitation of the low-energy triplet states at a low applied voltage by using the charge transfer (CT) state as a precursor and triplet-triplet annihilation, which forms one emissive singlet from two triplet excitons.
Disentangling age, gender, and racial/ethnic disparities in multiple myeloma burden: a modeling study
Authors: Huber John H. , Ji Mengmeng , Shih Yi-Hsuan , Wang Mei , Colditz Graham , Chang Su-Hsin 
Published: September 2023

AbstractMultiple myeloma (MM) is a hematological malignancy that is consistently preceded by an asymptomatic condition, monoclonal gammopathy of undetermined significance (MGUS). Disparities by age, gender, and race/ethnicity in both MGUS and MM are well-established. However, it remains unclear whether these disparities can be explained by increased incidence of MGUS and/or accelerated progression from MGUS to MM. Here, we fit a mathematical model to nationally representative data from the United States and showed that the difference in MM incidence can be explained by an increased incidence of MGUS among male and non-Hispanic Black populations. We did not find evidence showing differences in the rate of progression from MGUS to MM by either gender or race/ethnicity. Our results suggest that screening for MGUS among high-risk groups (e.g., non-Hispanic Black men) may hold promise as a strategy to reduce the burden and MM health disparities.
Microrollers flow uphill as granular media
Authors: Wilson-Whitford Samuel R. , Gao Jinghui , Roffin Maria Chiara , Buckley William E. , Gilchrist James F. 
Published: September 2023

AbstractPour sand into a container and only the grains near the top surface move. The collective motion associated with the translational and rotational energy of the grains in a thin flowing layer is quickly dissipated as friction through multibody interactions. Alternatively, consider what will happen to a bed of particles if one applies a torque to each individual particle. In this paper, we demonstrate an experimental system where torque is applied at the constituent level through a rotating magnetic field in a dense bed of microrollers. The net result is the grains roll uphill, forming a heap with a negative angle of repose. Two different regimes have been identified related to the degree of mobility or fluidisation of the particles in the bulk. Velocimetry of the near surface flowing layer reveals the collective motion of these responsive particles scales in a similar way to flowing bulk granular flows. A simple granular model that includes cohesion accurately predicts the apparent negative coefficient of friction. In contrast to the response of active or responsive particles that mimic thermodynamic principles, this system results in macroscopic collective behavior that has the kinematics of a purely dissipative granular system.
Capturing dynamical correlations using implicit neural representations
Authors: Chitturi Sathya R. , Ji Zhurun , Petsch Alexander N. , Peng Cheng , Chen Zhantao , Plumley Rajan , Dunne Mike , Mardanya Sougata , Chowdhury Sugata , Chen Hongwei , Bansil Arun , Feiguin Adrian , Kolesnikov Alexander I. , Prabhakaran Dharmalingam , Hayden Stephen M. , Ratner Daniel , Jia Chunjing , Nashed Youssef , Turner Joshua J. 
Published: September 2023

AbstractUnderstanding the nature and origin of collective excitations in materials is of fundamental importance for unraveling the underlying physics of a many-body system. Excitation spectra are usually obtained by measuring the dynamical structure factor, S(Q, ω), using inelastic neutron or x-ray scattering techniques and are analyzed by comparing the experimental results against calculated predictions. We introduce a data-driven analysis tool which leverages ‘neural implicit representations’ that are specifically tailored for handling spectrographic measurements and are able to efficiently obtain unknown parameters from experimental data via automatic differentiation. In this work, we employ linear spin wave theory simulations to train a machine learning platform, enabling precise exchange parameter extraction from inelastic neutron scattering data on the square-lattice spin-1 antiferromagnet La2NiO4, showcasing a viable pathway towards automatic refinement of advanced models for ordered magnetic systems.
Fgf signalling triggers an intrinsic mesodermal timer that determines the duration of limb patterning
Authors: Sedas Perez Sofia , McQueen Caitlin , Stainton Holly , Pickering Joseph , Chinnaiya Kavitha , Saiz-Lopez Patricia , Placzek Marysia , Ros Maria A. , Towers Matthew 
Published: September 2023

AbstractComplex signalling between the apical ectodermal ridge (AER - a thickening of the distal epithelium) and the mesoderm controls limb patterning along the proximo-distal axis (humerus to digits). However, the essential in vivo requirement for AER-Fgf signalling makes it difficult to understand the exact roles that it fulfils. To overcome this barrier, we developed an amenable ex vivo chick wing tissue explant system that faithfully replicates in vivo parameters. Using inhibition experiments and RNA-sequencing, we identify a transient role for Fgfs in triggering the distal patterning phase. Fgfs are then dispensable for the maintenance of an intrinsic mesodermal transcriptome, which controls proliferation/differentiation timing and the duration of patterning. We also uncover additional roles for Fgf signalling in maintaining AER-related gene expression and in suppressing myogenesis. We describe a simple logic for limb patterning duration, which is potentially applicable to other systems, including the main body axis.
Reviving product states in the disordered Heisenberg chain
Authors: Wilming Henrik , Osborne Tobias J. , Decker Kevin S. C. , Karrasch Christoph 
Published: September 2023

AbstractWhen a generic quantum system is prepared in a simple initial condition, it typically equilibrates toward a state that can be described by a thermal ensemble. A known exception is localized systems that are non-ergodic and do not thermalize; however, local observables are still believed to become stationary. Here we demonstrate that this general picture is incomplete by constructing product states that feature periodic high-fidelity revivals of the full wavefunction and local observables that oscillate indefinitely. The system neither equilibrates nor thermalizes. This is analogous to the phenomenon of weak ergodicity breaking due to many-body scars and challenges aspects of the current phenomenology of many-body localization, such as the logarithmic growth of the entanglement entropy. To support our claim, we combine analytic arguments with large-scale tensor network numerics for the disordered Heisenberg chain. Our results hold for arbitrarily long times in chains of 160 sites up to machine precision.
A metal-free photoactive nitrogen-doped carbon nanosolenoid with broad absorption in visible region for efficient photocatalysis
Authors: Zhou Yu , Zhang Xinyu , Sheng Guan , Wang Shengda , Chen Muqing , Zhuang Guilin , Zhu Yihan , Du Pingwu 
Published: September 2023

Abstract
Riemann surfaces inspired chemists to design and synthesize such multidimensional curved carbon architectures. It has been predicted that carbon nanosolenoid materials with Riemann surfaces have unique structures and novel physical properties. Here we report the first synthesis of a nitrogen-doped carbon nanosolenoid (N-CNS) using bottom-up approach with a well-defined structure. N-CNS was obtained by a rational Suzuki polymerization, followed by oxidative cyclodehydrogenation. The successful synthesis of N-CNS was fully characterized by GPC, FTIR, solid-state 13C NMR and Raman techniques. The intrinsic single-strand molecular structures of N-CNS helices can be clearly resolved using low-dose integrated differential phase contrast scanning transmission electron microscopy (iDPC-STEM) technique. Possessing unique structural and physical properties, this long π-extended polymer N-CNS can provide new insight towards bottom-up syntheses of curved nanoribbons and potential applications as a metal-free photocatalyst for visible-light-driven H2 evolution and highly efficient photocatalyst for photoredox organic transformations.
Structural basis for the activation of a compact CRISPR-Cas13 nuclease
Authors: Deng Xiangyu , Osikpa Emmanuel , Yang Jie , Oladeji Seye J. , Smith Jamie , Gao Xue , Gao Yang 
Published: September 2023

AbstractThe CRISPR-Cas13 ribonucleases have been widely applied for RNA knockdown and transcriptional modulation owing to their high programmability and specificity. However, the large size of Cas13 effectors and their non-specific RNA cleavage upon target activation limit the adeno-associated virus based delivery of Cas13 systems for therapeutic applications. Herein, we report detailed biochemical and structural characterizations of a compact Cas13 (Cas13bt3) suitable for adeno-associated virus delivery. Distinct from many other Cas13 systems, Cas13bt3 cleaves the target and other nonspecific RNA at internal “UC” sites and is activated in a target length-dependent manner. The cryo-electron microscope structure of Cas13bt3 in a fully active state illustrates the structural basis of Cas13bt3 activation. Guided by the structure, we obtain engineered Cas13bt3 variants with minimal off-target cleavage yet maintained target cleavage activities. In conclusion, our biochemical and structural data illustrate a distinct mechanism for Cas13bt3 activation and guide the engineering of Cas13bt3 applications.
Mechanodetection of neighbor plants elicits adaptive leaf movements through calcium dynamics
Authors: Pantazopoulou Chrysoula K. , Buti Sara , Nguyen Chi Tam , Oskam Lisa , Weits Daan A. , Farmer Edward E. , Kajala Kaisa , Pierik Ronald 
Published: September 2023

AbstractPlants detect their neighbors via various cues, including reflected light and touching of leaf tips, which elicit upward leaf movement (hyponasty). It is currently unknown how touch is sensed and how the signal is transferred from the leaf tip to the petiole base that drives hyponasty. Here, we show that touch-induced hyponasty involves a signal transduction pathway that is distinct from light-mediated hyponasty. We found that mechanostimulation of the leaf tip upon touching causes cytosolic calcium ([Ca2+]cyt induction in leaf tip trichomes that spreads towards the petiole. Both perturbation of the calcium response and the absence of trichomes reduce touch-induced hyponasty. Finally, using plant competition assays, we show that touch-induced hyponasty is adaptive in dense stands of Arabidopsis. We thus establish a novel, adaptive mechanism regulating hyponastic leaf movement in response to mechanostimulation by neighbors in dense vegetation.
Organic radical ferroelectric crystals with martensitic phase transition
Authors: Zhang Nan , Sun Wencong , Zhang Yao , Jiang Huan-Huan , Xiong Ren-Gen , Dong Shuai , Zhang Han-Yue 
Published: September 2023

AbstractOrganic martensitic compounds are an emerging type of smart material with intriguing physical properties including thermosalient effect, ferroelasticity, and shape memory effect. However, due to the high structural symmetry and limited design theories for these materials, the combination of ferroelectricity and martensitic transformation has rarely been found in organic systems. Here, based on the chemical design strategies for molecular ferroelectrics, we show a series of asymmetric 1,4,5,8-naphthalenediimide derivatives with the homochiral amine and 2,2,6,6-tetramethylpiperidine-N-oxyl components, which adopt the low-symmetric polar structure and so allow ferroelectricity. Upon H/F substitution, the fluorinated compounds exhibit reversible ferroelectric and martensitic transitions at 399 K accompanied by a large thermal hysteresis of 132 K. This large thermal hysteresis with two competing (meta)-stable phases is further confirmed by density functional theory calculations. The rare combination of martensitic phase transition and ferroelectricity realizes the bistability with two different ferroelectric phases at room temperature. Our finding provides insight into the exploration of martensitic ferroelectric compounds with potential applications in switchable memory devices, soft robotics, and smart actuators.
Critical requirement of SOS1 for tumor development and microenvironment modulation in KRASG12D-driven lung adenocarcinoma
Authors: Baltanás Fernando C. , García-Navas Rósula , Rodríguez-Ramos Pablo , Calzada Nuria , Cuesta Cristina , Borrajo Javier , Fuentes-Mateos Rocío , Olarte-San Juan Andrea , Vidaña Nerea , Castellano Esther , Santos Eugenio 
Published: September 2023

AbstractThe impact of genetic ablation of SOS1 or SOS2 is evaluated in a murine model of KRASG12D-driven lung adenocarcinoma (LUAD). SOS2 ablation shows some protection during early stages but only SOS1 ablation causes significant, specific long term increase of survival/lifespan of the KRASG12D mice associated to markedly reduced tumor burden and reduced populations of cancer-associated fibroblasts, macrophages and T-lymphocytes in the lung tumor microenvironment (TME). SOS1 ablation also causes specific shrinkage and regression of LUAD tumoral masses and components of the TME in pre-established KRASG12D LUAD tumors. The critical requirement of SOS1 for KRASG12D-driven LUAD is further confirmed by means of intravenous tail injection of KRASG12D tumor cells into SOS1KO/KRASWT mice, or of SOS1-less, KRASG12D tumor cells into wildtype mice. In silico analyses of human lung cancer databases support also the dominant role of SOS1 regarding tumor development and survival in LUAD patients. Our data indicate that SOS1 is critically required for development of KRASG12D-driven LUAD and confirm the validity of this RAS-GEF activator as an actionable therapeutic target in KRAS mutant LUAD.
Boosting urea electrooxidation on oxyanion-engineered nickel sites via inhibited water oxidation
Authors: Gao Xintong , Bai Xiaowan , Wang Pengtang , Jiao Yan , Davey Kenneth , Zheng Yao , Qiao Shi-Zhang 
Published: September 2023

AbstractRenewable energy-based electrocatalytic oxidation of organic nucleophiles (e.g.methanol, urea, and amine) are more thermodynamically favourable and, economically attractive to replace conventional pure water electrooxidation in electrolyser to produce hydrogen. However, it is challenging due to the competitive oxygen evolution reaction under a high current density (e.g., >300 mA cm−2), which reduces the anode electrocatalyst’s activity and stability. Herein, taking lower energy cost urea electrooxidation reaction as the model reaction, we developed oxyanion-engineered Nickel catalysts to inhibit competing oxygen evolution reaction during urea oxidation reaction, achieving an ultrahigh 323.4 mA cm−2 current density at 1.65 V with 99.3 ± 0.4% selectivity of N-products. In situ spectra studies reveal that such in situ generated oxyanions not only inhibit OH− adsorption and guarantee high coverage of urea reactant on active sites to avoid oxygen evolution reaction, but also accelerate urea’s C − N bond cleavage to form CNO − intermediates for facilitating urea oxidation reaction. Accordingly, a comprehensive mechanism for competitive adsorption behaviour between OH− and urea to boost urea electrooxidation and dynamic change of Ni active sites during urea oxidation reaction was proposed. This work presents a feasible route for high-efficiency urea electrooxidation reaction and even various electrooxidation reactions in practical applications.
Sensory cortex plasticity supports auditory social learning
Authors: Paraouty Nihaad , Yao Justin D. , Varnet Léo , Chou Chi-Ning , Chung SueYeon , Sanes Dan H. 
Published: September 2023

AbstractSocial learning (SL) through experience with conspecifics can facilitate the acquisition of many behaviors. Thus, when Mongolian gerbils are exposed to a demonstrator performing an auditory discrimination task, their subsequent task acquisition is facilitated, even in the absence of visual cues. Here, we show that transient inactivation of auditory cortex (AC) during exposure caused a significant delay in task acquisition during the subsequent practice phase, suggesting that AC activity is necessary for SL. Moreover, social exposure induced an improvement in AC neuron sensitivity to auditory task cues. The magnitude of neural change during exposure correlated with task acquisition during practice. In contrast, exposure to only auditory task cues led to poorer neurometric and behavioral outcomes. Finally, social information during exposure was encoded in the AC of observer animals. Together, our results suggest that auditory SL is supported by AC neuron plasticity occurring during social exposure and prior to behavioral performance.
Soil heat extremes can outpace air temperature extremes
Authors: García-García Almudena , Cuesta-Valero Francisco José , Miralles Diego G. , Mahecha Miguel D. , Quaas Johannes , Reichstein Markus , Zscheischler Jakob , Peng Jian 
Published: September 2023

AbstractQuantifying changes in hot temperature extremes is key for developing adaptation strategies. Changes in hot extremes are often determined on the basis of air temperatures; however, hydrology and many biogeochemical processes are more sensitive to soil temperature. Here we show that soil hot extremes are increasing faster than air hot extremes by 0.7 °C per decade in intensity and twice as fast in frequency on average over Central Europe. Furthermore, we identify soil temperature as a key factor in the soil moisture–temperature feedback. During dry and warm conditions, the energy absorbed by the soil is used to warm the soil, increasing the release of sensible heat flux and surface air temperatures. This increase in surface air temperature leads to a higher atmospheric demand for water, increasing soil evaporation, which may further dry and warm the soil highlighting the contribution of soil moisture–temperature feedback to the evolution of hot extremes in a warming climate.
Global population exposure to landscape fire air pollution from 2000 to 2019
Authors: Xu Rongbin , Ye Tingting , Yue Xu , Yang Zhengyu , Yu Wenhua , Zhang Yiwen , Bell Michelle L. , Morawska Lidia , Yu Pei , Zhang Yuxi , Wu Yao , Liu Yanming , Johnston Fay , Lei Yadong , Abramson Michael J. , Guo Yuming , Li Shanshan 
Published: September 2023

AbstractWildfires are thought to be increasing in severity and frequency as a result of climate change1–5. Air pollution from landscape fires can negatively affect human health4–6, but human exposure to landscape fire-sourced (LFS) air pollution has not been well characterized at the global scale7–23. Here, we estimate global daily LFS outdoor fine particulate matter (PM2.5) and surface ozone concentrations at 0.25° × 0.25° resolution during the period 2000–2019 with the help of machine learning and chemical transport models. We found that overall population-weighted average LFS PM2.5 and ozone concentrations were 2.5 µg m−3 (6.1% of all-source PM2.5) and 3.2 µg m−3 (3.6% of all-source ozone), respectively, in 2010–2019, with a slight increase for PM2.5, but not for ozone, compared with 2000–2009. Central Africa, Southeast Asia, South America and Siberia experienced the highest LFS PM2.5 and ozone concentrations. The concentrations of LFS PM2.5 and ozone were about four times higher in low-income countries than in high-income countries. During the period 2010–2019, 2.18 billion people were exposed to at least 1 day of substantial LFS air pollution per year, with each person in the world having, on average, 9.9 days of exposure per year. These two metrics increased by 6.8% and 2.1%, respectively, compared with 2000–2009. Overall, we find that the global population is increasingly exposed to LFS air pollution, with socioeconomic disparities.
Detection of transcriptome-wide microRNA–target interactions in single cells with agoTRIBE
Authors: Sekar Vaishnovi , Mármol-Sánchez Emilio , Kalogeropoulos Panagiotis , Stanicek Laura , Sagredo Eduardo A. , Widmark Albin , Doukoumopoulos Evangelos , Bonath Franziska , Biryukova Inna , Friedländer Marc R. 
Published: September 2023

AbstractMicroRNAs (miRNAs) exert their gene regulatory effects on numerous biological processes based on their selection of target transcripts. Current experimental methods available to identify miRNA targets are laborious and require millions of cells. Here we have overcome these limitations by fusing the miRNA effector protein Argonaute2 to the RNA editing domain of ADAR2, allowing the detection of miRNA targets transcriptome-wide in single cells. miRNAs guide the fusion protein to their natural target transcripts, causing them to undergo A>I editing, which can be detected by sensitive single-cell RNA sequencing. We show that agoTRIBE identifies functional miRNA targets, which are supported by evolutionary sequence conservation. In one application of the method we study microRNA interactions in single cells and identify substantial differential targeting across the cell cycle. AgoTRIBE also provides transcriptome-wide measurements of RNA abundance and allows the deconvolution of miRNA targeting in complex tissues at the single-cell level.
Discrimination of cell-intrinsic and environment-dependent effects of natural genetic variation on Kupffer cell epigenomes and transcriptomes
Authors: Bennett Hunter , Troutman Ty D. , Zhou Enchen , Spann Nathanael J. , Link Verena M. , Seidman Jason S. , Nickl Christian K. , Abe Yohei , Sakai Mashito , Pasillas Martina P. , Marlman Justin M. , Guzman Carlos , Hosseini Mojgan , Schnabl Bernd , Glass Christopher K. 
Published: September 2023

AbstractNoncoding genetic variation drives phenotypic diversity, but underlying mechanisms and affected cell types are incompletely understood. Here, investigation of effects of natural genetic variation on the epigenomes and transcriptomes of Kupffer cells derived from inbred mouse strains identified strain-specific environmental factors influencing Kupffer cell phenotypes, including leptin signaling in Kupffer cells from a steatohepatitis-resistant strain. Cell-autonomous and non-cell-autonomous effects of genetic variation were resolved by analysis of F1 hybrid mice and cells engrafted into an immunodeficient host. During homeostasis, non-cell-autonomous trans effects of genetic variation dominated control of Kupffer cells, while strain-specific responses to acute lipopolysaccharide injection were dominated by actions of cis-acting effects modifying response elements for lineage-determining and signal-dependent transcription factors. These findings demonstrate that epigenetic landscapes report on trans effects of genetic variation and serve as a resource for deeper analyses into genetic control of transcription in Kupffer cells and macrophages in vitro.