bluuebunny/crossref_metadata_2025_split huggingface dataset:
Marx and the Dephysicalisation of the Landscape
Authors: Byer Amanda 
Published: June 2023

AbstractThis chapter relies on Marx’s later critiques of capitalism (which focused on the relationship between property rights and nature) to explain the final hallmark of property: alienability. Using Marx's metabolic rift theory, the chapter considers how the abstraction of land was achieved through the separation of culture and nature, which created distance between people and their embedded relations with land. This is illustrated with examples from rundale communities in Ireland and the slave colonies of the Caribbean. Converting landscapes to plantation monoculture to maximise exploitation destabilised the landscape dynamic, facilitating displacement, oppression, and enslavement, and socio-ecological crises such as the Famine. The chapter thus draws attention to the spatial consequences of land's dephysicalisation in property law.
Conclusion: Property’s Placelessness
Authors: Byer Amanda 
Published: June 2023

AbstractThe closing chapter recaps the book’s objectives, which were to determine property’s origins, now identified in pre-feudal landscape, recover the spatial parameters of the theories of Locke, Blackstone and Marx, which are foundational to classical property theory, and highlight the process of converting landscapes to property as an exercise in spatial injustice that is facilitated by the law. This process was not linear or progressive, in response to land’s environmental limits, but executed through enclosure, displacement and colonisation. As a result, the chapter contends that a legal geographical perspective reveals that property is based on detachment from place, and this placelessness has implications for sustainable land use today.
The emergence proposal in quantum gravity and the species scale
Authors: Castellano A. , Herráez A. , Ibáñez L. E. 
Published: June 2023

Abstract
In the Emergence Proposal in Quantum Gravity it is conjectured that all light-particle kinetic terms are absent in the fundamental ultraviolet theory and are generated by quantum corrections in the infrared. It has been argued that this may provide for some microscopic understanding of the Weak Gravity and Distance conjectures. In the present paper we take the first steps towards a systematic study of Emergence in the context of string theory. We emphasize the crucial role of the species scale in any effective field theory coupled to gravity, and discuss its computation in string theory and general systems with light towers of states. We then introduce the notion of Emergence and show how kinetic terms for moduli, gauge bosons and fermions may be generated. One-loop computations play an important role in Emergence, so we present detailed calculations in d spacetime dimensions for the wave-function renormalization of scalars, vectors and fermions. We extend and check the Emergence Proposal in a number string vacua, including 4d $$ \mathcal{N} $$
N
= 2 theories arising from type IIA on a CY3, where the towers at strong coupling are comprised by D0 and (wrapped) D2-branes, and also elaborate on how instanton corrections would fit within the emergence picture. Higher dimensional examples are also discussed, including 6d and 7d models arising from F-/M-theory on an elliptic CY3 or a K3 surface. We also consider 10d string theories and study in some detail the emergence mechanism in type IIA. We show as well how the flux potential in 4d may be obtained from the emergence prescription, by analyzing the corresponding decompactification limits to M-theory. We find that the required kinetic terms for the dual 3-form fields can arise upon integrating out towers of massive gravitini (and bosonic superpartners). Our analysis renders support to the Emergence Proposal, and to the idea that infinite distance singularities may arise in Quantum Gravity as an intrinsic infrared phenomenon.
Ladder and zig-zag Feynman diagrams, operator formalism and conformal triangles
Authors: Derkachov S. E. , Isaev A. P. , Shumilov L. A. 
Published: June 2023

Abstract
We develop an operator approach to the evaluation of multiple integrals for multiloop Feynman massless diagrams. A commutative family of graph building operators Hα for ladder diagrams is constructed and investigated. The complete set of eigenfunctions and the corresponding eigenvalues for the operators Hα are found. This enables us to explicitly express a wide class of four-point ladder diagrams and a general two-loop propagator-type master diagram (with arbitrary indices on the lines) as Mellin-Barnes-type integrals. Special cases of these integrals are explicitly evaluated. A certain class of zig-zag four-point and two-point planar Feynman diagrams (relevant to the bi-scalar D-dimensional “fishnet” field theory and to the calculation of the β-function in ϕ4-theory) is considered. The graph building operators and convenient integral representations for these Feynman diagrams are obtained. The explicit form of the eigenfunctions for the graph building operators of the zig-zag diagrams is fixed by conformal symmetry and these eigenfunctions coincide with the 3-point correlation functions in D-dimensional conformal field theories. By means of this approach, we exactly evaluate the diagrams of the zig-zag series in special cases. In particular, we find a fairly simple derivation of the values for the zig-zag multi-loop two-point diagrams for D = 4. The role of conformal symmetry in this approach, especially a connection of the considered graph building operators with conformal invariant solutions of the Yang-Baxter equation is investigated in detail.
Where is M-theory in the space of scattering amplitudes?
Authors: Guerrieri Andrea , Murali Harish , Penedones Joao , Vieira Pedro 
Published: June 2023

Abstract
We use the S-matrix bootstrap to carve out the space of unitary, analytic, crossing symmetric and supersymmetric graviton scattering amplitudes in nine, ten and eleven dimensions. We extend and improve the numerical methods of our previous work in ten dimensions. A key new tool employed here is unitarity in the celestial sphere. In all dimensions, we find that the minimal allowed value of the Wilson coefficient α, controlling the leading correction to maximal supergravity, is very close but not equal to the minimal value realized in Superstring theory or M-theory. This small difference may be related to inelastic effects that are not well described by our numerical extremal amplitudes. Although α has a unique value in M-theory, we found no evidence of an upper bound on α in 11D.
Webbasierter Kontaminantenrechner in der Risikobewertung – ein hilfreiches Tool?
Authors: Mielke Hans , Abraham Klaus , Beyvers Stephanie , Blume Katrin , Böl Gaby-Fleur , Ehlers Anke , Flor Matthias , Gürtler Rainer , Kolbaum Anna Elena , Kühn Juana , Lindtner Oliver , Lohmann Mark , Merkel Stefan , Pabel Ulrike , Schäfer Bernd , Schafft Helmut , Sieke Christian , Stehfest Susann , Uhlig Katrin , Müller-Graf Christine , Greiner Matthias 
Published: June 2023

ZusammenfassungZiel dieser Arbeit ist die Beschreibung der Entwicklung einer webbasierten, interaktiven Darstellung von maximalen tolerierbaren Verzehrmengen für ausgewählte Lebensmittel, die beispielsweise in einer Ereignissituation als potenziell kontaminiert angenommen werden („Kontaminantenrechner“). Die vorliegende Arbeit beschreibt einen Katalog wissenschaftlicher Anwendungskriterien für einen solchen Kontaminantenrechner. Als Anwendungsbeispiel wird der Fipronil-Ereignisfall im Sommer 2017 verwendet.
Establishing Equal-Channel Angular Pressing (ECAP) for sheet metals by using backpressure: manufacturing of high-strength aluminum AA5083 sheets
Authors: Gruber Maximilian , Illgen Christian , Lichte Felix , Hartmann Christoph , Frint Philipp , Wagner Martin F.-X. , Volk Wolfram 
Published: June 2023

AbstractSevere plastic deformation (SPD) processes offer the possibility of improving the mechanical properties of metallic materials by grain refinement. However, this great potential has so far mostly been applied on a laboratory scale or on small series. Equal-Channel Angular Pressing (ECAP) also enables to integrate the advantages in industrial processes with large output—so far, mainly for bars or thick plates. In this paper, we investigate the ECAP process for sheet metal. Preliminary investigations have shown that cracks form on the surface when aluminum AA5083 sheets are processed. To solve this problem, we determined the Johnson–Cook fracture criterion for the material and modeled the process numerically. The simulation was carried out with the superposition of a backpressure and subsequently implemented and validated experimentally. The semi-finished sheet metal products from the ECAP investigation were then mechanically characterized with microhardness measurements and tensile tests. In addition, the microstructure was investigated with Electron Back Scatter Diffraction (EBSD). Even comparatively small amounts of backpressure (10 MPa) already result in a significant suppression of the crack formation in the numerical and experimental investigations. The microhardness measurements indicate a more homogeneous strain distribution for a sufficient level of applied backpressure which enables the processing of crack-free sheets in multiple ECAP passes. As with ECAP of bulk materials, tensile tests on the processed sheets show a reduced elongation to failure (− 73%) but a significantly increased yield strength (+ 157%) compared to the initial condition of the material. Distinct substructures are found in the EBSD measurements and explain this behavior. The findings provide the basis for using ECAP on an application-oriented scale and demonstrate an advanced manufacturing method for the production of high-strength aluminum sheets.
A Nomothetic Span Approach to the Construct Validation of Sustained Attention Consistency: Re-Analyzing Two Latent-Variable Studies of Performance Variability and Mind-Wandering Self-Reports
Authors: Welhaf Matthew S. , Kane Michael J. 
Published: June 2023

AbstractThe ability to sustain attention consistency is frequently assessed using either objective behavioral measures, such as reaction time (RT) variability, or subjective self-report measures, such as rates of task-unrelated thought (TUT). The current studies examined whether the individual-difference covariation in these measures provides a more construct valid assessment of attention consistency than does either alone. We argue that performance and self-report measures mutually validate each other; each measurement approach has its own sources of error, so their shared variance should best reflect the attention consistency construct. We reanalyzed two latent-variable studies where RT variability and TUTs were measured in multiple tasks (Kane et al. in J Exp Psychol Gen 145:1017–1048, 2016; Unsworth et al. in J Exp Psychol Gen 150:1303–1331, 2021), along with several nomological network constructs to test the convergent and discriminant validity of a general attention consistency factor. Confirmatory factor analyses assessing bifactor (preregistered) and hierarchical (non-preregistered) models suggested that attention consistency can be modeled as the shared variance among objective and subjective measures. This attention consistency factor was related to working memory capacity, attention (interference) control, processing speed, state motivation and alertness, and self-reported cognitive failures and positive schizotypy. Although bifactor models of general attention consistency provide the most compelling construct validity evidence for a specific ability to sustain attention, multiverse analyses of outlier decisions suggested they are less robust than hierarchical models. The results provide evidence for the general ability to sustain attention consistency and suggestions for improving its measurement.
Real-world evidence of osimertinib in Chinese patients with EGFR T790M-positive non-small cell lung cancer: a subgroup analysis from ASTRIS study
Authors: Zhou Qing , Zhang He-Long , Jiang Li-Yan , Shi Yuan-Kai , Chen Yuan , Yu Jin-Ming , Zhou Cai-Cun , He Yong , Hu Yan-Ping , Liang Zong-An , Pan Yue-Yin , Zhuo Wen-Lei , Song Yong , Wu Gang , Chen Gong-Yan , Lu You , Zhang Cui-Ying , Zhang Yi-Ping , Cheng Ying , Lu Shun , Wang Chang-Li , Zhou Jian-Ying , Liu Yun-Peng , He Jian-Xing , Wang Jie , Wu Yi-Long 
Published: June 2023

Abstract
Purpose
ASTRIS study aimed the largest to evaluate the effectiveness and safety of second- or higher-line osimertinib in patients with advanced/metastatic epidermal growth factor receptor (EGFR) T790M mutation-positive non–small cell lung cancer (NSCLC) in the real-world setting. Here we report the results of Chinese patients in ASTRIS study.

Methods
Adults with EGFR T790M-positive advanced NSCLC pretreated with EGFR-tyrosine kinase inhibitor (EGFR-TKI), having a WHO performance status score of 0–2 and asymptomatic, stable central nervous system (CNS) metastases were included. All patients received once-daily osimertinib 80 mg orally. The outcomes included investigator-assessed clinical response, progression-free survival (PFS), time-to-treatment discontinuation (TTD), and safety.

Results
A total of 1350 patients were included. Response rate was 55.7% (95% confidence interval [CI] 0.53–0.58). The median PFS and the median TTD were 11.7 months (95% CI 11.1–12.5) and 13.9 months (95% CI 13.1–15.2), respectively. Overall, 389 patients (28.8%) had at least one protocol-specified adverse event (AE); AEs of interstitial lung diseases/pneumonitis-like events and QT prolongation were reported in 3 (0.2%) and 59 (4.4%) patients, respectively.

Conclusion
Osimertinib was effective in Chinese patients with T790M-positive NSCLC who had progressed after first- or second-generation EGFR-TKI in real-word setting and the results were consistent with ASTRIS study overall population and AURA studies. No new safety signals or events were identified.

Clinical trial number
NCT02474355.
Association of CDKN2A/B mutations, PD-1, and PD-L1 with the risk of acute lymphoblastic leukemia in children
Authors: Ruan Yang , Xie Longlong , Zou Aijun 
Published: June 2023

Abstract
Purpose
Currently, the significance of CDKN2A/B mutations in the pathogenesis and prognosis of acute lymphoblastic leukemia (ALL) is inconclusive. In this study, we analyzed the genetic and clinical features of children with CDKN2A/B mutations in ALL. In addition, we evaluated the expression and significance of programmed cell death protein 1 (PD-1) and programmed cell death ligand 1 (PD-L1) in serum and explored their role in the susceptibility of childhood ALL.

Methods
We sequenced CDKN2A/B in the peripheral blood of 120 children with ALL and 100 healthy children with physical examination. The levels of CD4+ T, CD8+ T, and NK cells were measured by flow cytometry (FCM). Furthermore, the expression of PD-1 and PD-L1 was detected by ELISA.

Results
We found 32 cases of CDKN2A rs3088440 and 11 of CDKN2B rs2069426 in 120 ALL children. Children with ALL in the CDKN2A rs3088440 were more likely to have hepatosplenomegaly (P = 0.019) and high risk (P = 0.014) than the wild group. In contrast, CDKN2B rs2069426 was more likely to develop lymph node metastasis (P = 0.017). The level of PD-L1 in the serum of ALL children was significantly higher than that of the control group, and there was no significant difference in PD-1 (P < 0.001). Additionally, children with CDKN2A rs3088440 had reduced CD8+ T cell counts than the wild group (P = 0.039).

Conclusion
CDKN2A rs3088440 and CDKN2B rs2069426 may be related to the occurrence and development of ALL in Chinese children. Additionally, PD-1/PD-L1 may be involved in the immune escape process of ALL, which is expected to become a new target for the treatment of the disease.
Psychotherapeutische Medizin in der psychiatrischen Fachärzt:innenausbildung in Österreich
Authors: Löffler-Stastka Henriette , Lugsch Martin , Aigner Martin 
Published: June 2023

ZusammenfassungDie vorliegende Arbeit beschreibt die Entwicklung der psychotherapeutischen Medizin innerhalb der ärztlich-psychiatrischen Fachärzt:innen-Ausbildung. Die Grundlage für die Kompetenzdarstellung bilden die einzelnen Rasterzeugnisse der Ausbildungsordnungen 1994, 2006, 2011 sowie 2015. Die Entwicklung der psychotherapeutischen Kompetenzen innerhalb der ärztlich-psychiatrischen Identität wird anhand des Qualifikations- und Kompetenzprofils sowie der Lernziele dargestellt.
Early neurological deterioration in Wilson’s disease: a systematic literature review and meta-analysis
Authors: Antos Agnieszka , Członkowska Anna , Smolinski Lukasz , Bembenek Jan , Przybyłkowski Adam , Skowrońska Marta , Kurkowska-Jastrzębska Iwona , Litwin Tomasz 
Published: June 2023

Abstract

Introduction
Neurological deterioration, soon after anti-copper treatment initiation, is problematic in the management of Wilson’s disease (WD) and yet reports in the literature are limited. The aim of our study was to systematically assess the data according to early neurological deteriorations in WD, its outcome and risk factors.

Methods
Using PRISMA guidelines, a systematic review of available data on early neurological deteriorations was performed by searching the PubMed database and reference lists. Random effects meta-analytic models summarized cases of neurological deterioration by disease phenotype.

Results
Across the 32 included articles, 217 cases of early neurological deterioration occurred in 1512 WD patients (frequency 14.3%), most commonly in patients with neurological WD (21.8%; 167/763), rarely in hepatic disease (1.3%; 5/377), and with no cases among asymptomatic individuals. Most neurological deterioration occurred in patients treated with d-penicillamine (70.5%; 153/217), trientine (14.2%; 31/217) or zinc salts (6.9%; 15/217); the data did not allow to determine if that reflects how often treatments were chosen as first line therapy or if the risk of deterioration differed with therapy. Symptoms completely resolved in 24.2% of patients (31/128), resolved partially in 27.3% (35/128), did not improve in 39.8% (51/128), with 11 patients lost to follow-up.

Conclusions
Given its occurrence in up to 21.8% of patients with neurological WD in this meta-analysis of small studies, there is a need for further investigations to distinguish the natural time course of WD from treatment-related early deterioration and to develop a standard definition for treatment-induced effects.
New degrees of freedom for differential forms on cubical meshes
Authors: Lohi Jonni 
Published: June 2023

AbstractWe consider new degrees of freedom for higher order differential forms on cubical meshes. The approach is inspired by the idea of Rapetti and Bossavit to define higher order Whitney forms and their degrees of freedom using small simplices. We show that higher order differential forms on cubical meshes can be defined analogously using small cubes and prove that these small cubes yield unisolvent degrees of freedom. Importantly, this approach is compatible with discrete exterior calculus and expands the framework to cover higher order methods on cubical meshes, complementing the earlier strategy based on simplices.
The α-(1,3)-glucan synthase gene agsE impacts the secretome of Aspergillus niger
Authors: Lyu Jun , Torchia Costanza , Post Harm , Moran Torres Juan P. , Altelaar A. F. Maarten , de Cock Hans , Wösten Han A. B. 
Published: June 2023

AbstractAspergillus niger is widely used as a cell factory for the industrial production of enzymes. Previously, it was shown that deletion of α-1–3 glucan synthase genes results in smaller micro-colonies in liquid cultures of Aspergillus nidulans. Also, it has been shown that small wild-type Aspergillus niger micro-colonies secrete more protein than large mirco-colonies. We here assessed whether deletion of the agsC or agsE α-1–3 glucan synthase genes results in smaller A. niger micro-colonies and whether this is accompanied by a change in protein secretion. Biomass formation was not affected in the deletion strains but pH of the culture medium had changed from 5.2 in the case of the wild-type to 4.6 and 6.4 for ΔagsC and ΔagsE, respectively. The diameter of the ΔagsC micro-colonies was not affected in liquid cultures. In contrast, diameter of the ΔagsE micro-colonies was reduced from 3304 ± 338 µm to 1229 ± 113 µm. Moreover, the ΔagsE secretome was affected with 54 and 36 unique proteins with a predicted signal peptide in the culture medium of MA234.1 and the ΔagsE, respectively. Results show that these strains have complementary cellulase activity and thus may have complementary activity on plant biomass degradation. Together, α-1–3 glucan synthesis (in)directly impacts protein secretion in A. niger.
An eco-sustainable innovative geotechnical technology for the structures seismic isolation, investigated by FEM parametric analyses
Authors: Abate Glenda , Fiamingo Angela , Massimino Maria Rossella 
Published: June 2023

AbstractGeotechnical Seismic Isolation (GSI) is an innovative technique for protecting structures in earthquake-prone areas. The main idea is to improve the foundation soil so that seismic energy is partially dissipated within GSI before being transmitted to the structure. Among other materials proposed for foundation soil improvement, gravel-rubber mixtures (GRMs), with rubber grains manufactured from end-of-life tires, have attracted significant research interest thanks to their good mechanical properties. GRMs also represent a modern recycling system to reduce the stockpile of scrap tires worldwide. The present study investigated numerically the effect of a GRM layer located underneath the shallow foundations of a real structure. The structure is a typical reinforced concrete building in southern Italy. A Finite Element Modelling (FEM) was carried out to evaluate the overall static and dynamic behaviour of the soil-GRMs-structure system. Three FEM models were performed with and without the GRM layer, varying the GRM layer thickness and the seismic inputs. The comparisons among the models allow us to assess the performance of the GRM underneath the foundations as a new eco-sustainable solution for the seismic isolation of structures.
Resolving the Ethical Tension Between Creating a Civil Environment and Facilitating Free Expression Online: Comment Reordering as an Alternative to Comment Moderation
Authors: Yadin Dena , Yahav Inbal , Zalmanson Lior , Munichor Nira 
Published: June 2023

AbstractIncivility in online commenting sections can create a hostile environment and result in the silencing of vulnerable voices. Accordingly, content websites and social media platforms have an ethical responsibility—one that aligns with their strategic interests—to minimize users' exposure to uncivil content. To this end, platforms invest great effort and budget in automatic and manual filtering mechanisms. Yet, these efforts create a competing ethical quandary, as they often come at the expense of free expression, particularly in cases where comments do not explicitly infringe on stated guidelines but might nevertheless be interpreted as offensive. In this paper, we examine an alternative moderation approach, based on comment reordering as opposed to deletion of uncivil comments. Specifically, we show that exposure to uncivil (vs. civil) comments located in the head or at the bottom of a list of comments increases subsequent commenters' likelihood of posting uncivil comments themselves. Exposure to uncivil comments in the middle of a list, however, does not significantly enhance commenters' likelihood of commenting uncivilly. These results offer new theoretical insight into how incivility is transferred between users in online environments. Our results also suggest a straightforward technological solution for mitigating online incivility, which is more ethical and practical than current industry standards. This involves placing civil comments at the beginning and end of the comment thread, with uncivil comments located in the middle.