bluuebunny/crossref_metadata_2025_split huggingface dataset:
On a skeletally immature individual of Unaysaurus tolentinoi (Dinosauria: Sauropodomorpha) from the upper Triassic of southern Brazil
Authors: Müller Rodrigo T. , Garcia Maurício S. , Bem Fabiula P. , Damke Lísie V. S. , Fonseca André O. , Da‐Rosa Átila A. S. 
Published: July 2023

AbstractThe lineage of sauropodomorph dinosaurs raised some of the most impressive animals that ever walked on Earth. However, the massive titans of the Mesozoic Era originated from far smaller dinosaurs. The Triassic beds from Brazil yielded the earliest part of this evolutionary history. Despite the diverse fossil record of early sauropodomorphs, juvenile specimens, as well as certain species are poorly sampled. This is the case for Unaysaurus tolentinoi, an unaysaurid sauropodomorph from Caturrita Formation (ca. 225 Ma; early Norian, Late Triassic). The holotype and only specimen of U. tolentinoi was excavated from the Água Negra Locality (São Martinho da Serra, Rio Grande do Sul, Brazil) in 1998. More than two decades later, no other fossil vertebrates have been reported from the same fossiliferous site. Here we describe a skeletally immature specimen which was found in association with the holotype of U. tolentinoi. The specimen was discovered after a first‐hand examination of the holotype and comprises some isolated vertebrae and elements from the posterior autopodium. According to linear regressions, its metatarsal I is approximately 41.7 mm in length, compared to approximately 75.9 mm in the holotype. The repeated elements and reduced size indicates that it does not belong to the elements originally used to erect U. tolentinoi. Rather, the specimen is assigned to U. tolentinoi by topotypy and shared morphology. In addition to the reduced size, distinct lines of evidence (e.g., neurocentral sutures; bone texture) support its assignment to a skeletally immature individual. In sum, the new material expands the record of U. tolentinoi, and represents an additional juvenile dinosaur from the Caturrita Formation.
IĸB Protein BCL3 as a Controller of Osteogenesis and Bone Health
Authors: Jaffery Hussain , Huesa Carmen , Chilaka Sabarinadh , Cole John , Doonan James , Akbar Moeed , Dunning Lynette , Tanner Kathleen Elizabeth , van ‘t Hof Rob J. , McInnes Iain B. , Carmody Ruaidhrí J. , Goodyear Carl S. 
Published: July 2023

ObjectiveIĸB protein B cell lymphoma 3‐encoded protein (BCL3) is a regulator of the NF‐κB family of transcription factors. NF‐κB signaling fundamentally influences the fate of bone‐forming osteoblasts and bone‐resorbing osteoclasts, but the role of BCL3 in bone biology has not been investigated. The objective of this study was to evaluate BCL3 in skeletal development, maintenance, and osteoarthritic pathology.MethodsTo assess the contribution of BCL3 to skeletal homeostasis, neonatal mice (n = 6–14) lacking BCL3 (Bcl3−/−) and wild‐type (WT) controls were characterized for bone phenotype and density. To reveal the contribution to bone phenotype by the osteoblast compartment in Bcl3−/− mice, transcriptomic analysis of early osteogenic differentiation and cellular function (n = 3–7) were assessed. Osteoclast differentiation and function in Bcl3−/− mice (n = 3–5) was assessed. Adult 20‐week Bcl3−/− and WT mice bone phenotype, strength, and turnover were assessed. A destabilization of the medial meniscus model of osteoarthritic osteophytogenesis was used to understand adult bone formation in Bcl3−/− mice (n = 11–13).ResultsEvaluation of Bcl3−/− mice revealed congenitally increased bone density, long bone dwarfism, increased bone biomechanical strength, and altered bone turnover. Molecular and cellular characterization of mesenchymal precursors showed that Bcl3−/− cells displayed an accelerated osteogenic transcriptional profile that led to enhanced differentiation into osteoblasts with increased functional activity, which could be reversed with a mimetic peptide. In a model of osteoarthritis‐induced osteophytogenesis, Bcl3−/− mice exhibited decreased pathological osteophyte formation (P < 0.05).ConclusionCumulatively, these findings demonstrate that BCL3 controls developmental mineralization to enable appropriate bone formation, whereas in a pathological setting, it contributes to skeletal pathology.image
Event‐triggered containment control for multi‐agent systems under hybrid cyber attacks
Authors: Zhu Hongfei , Liu Jinhai , Zhang Shuo , Zhang Zhigang 
Published: July 2023

AbstractThis paper studies event‐triggered containment control problem of multi‐agent systems (MASs) under deception attacks and denial‐of‐service (DoS) attacks. First, to save limited network resources, an event‐triggered mechanism is proposed for MASs under hybrid cyber attacks. Different from the existing event‐triggered mechanisms, the negative influences of deception attacks and DoS attacks are considered in the proposed triggering function. The communication frequencies between agents are reduced. Then, based on the proposed event‐triggered mechanism, a corresponding control protocol is proposed to ensure that the followers will converge to the convex hull formed by the leaders under deception attacks and DoS attacks. Compared with the previous researches about containment control, in addition to hybrid cyber attacks being considered, the nonlinear functions related to the states of the agents are applied to describe the deception attack signals in the MAS. By orthogonal transformation of deception attack signals, the containment control problem under deception attacks and DoS attacks is reformulated as a stability problem. Then, the sufficient conditions on containment control can be obtained. Finally, a set of simulation example is used to verify the effectiveness of the proposed method.
Chemiluminescence method based on the KIO4−K2CO3−Mn2+ reaction for rapid and sensitive determination of forchlorfenuron in dried fruit
Authors: Chen Baisen , Tan Rongxia , Hu Yufei , Li Gongke 
Published: July 2023

AbstractForchlorfenuron is a low‐toxic phenylurea plant growth regulator. Excessive intake of forchlorfenuron can lead to metabolic disorders of the matrix and be harmful to human health. The chemiluminescence intensity of the KIO4–K2CO3–Mn2+ reaction decreased in the presence of forchlorfenuron. Based on this result, a rapid and sensitive chemiluminescence method was established to determine forchlorfenuron by combining it with a batch injection static device. The injection speed, injection volume and reagent concentration of the forchlorfenuron–KIO4–K2CO3–Mn2+ chemiluminescence reaction were optimized. Under these optimized conditions, the linear range of the method was 1.0–200.0 μg/L, and the limit of detection was 0.29 μg/L (S/N = 3). The chemiluminescence method for the determination of forchlorfenuron could be completed in 10 s. The method was applied to detect the residual forchlorfenuron in dried fruit samples, and the results are consistent with high‐performance liquid chromatography‐mass spectrometry. This method has the advantages of high sensitivity, rapid response, less reagent consumption, and convenient operation. It will provide a new perspective for chemiluminescence for the rapid and sensitive determination of forchlorfenuron in various complex samples.
Lipopolysaccharide‐induced sickness behavior is not altered in male Fmr1‐deficient mice
Authors: Santana‐Coelho Danielle , Hodges Samantha L. , Quintero Saul I. , Womble Paige D. , Sullens D. Greg , Narvaiz David A. , Herrera Rebecca , Sekeres Melanie J. , Lugo Joaquin N. 
Published: July 2023

AbstractObjectivesFragile X syndrome is the main monogenetic cause of intellectual disability and autism. Alterations in the immune system are commonly found in these developmental disorders. We and others have demonstrated that Fmr1 mutant mice present an altered response to immune stimuli. However, whether this altered immune response can influence the Fmr1 mutant behavioral outcomes in response to inflammation has not been fully investigated.Materials and methodsIn the current study, we examine the behavioral sickness response of male wildtype and knockout mice to the innate immune stimulus lipopolysaccharide (LPS) (0.1 mg/kg) to determine if Fmr1 mutants have altered sickness behavior. We used an enzyme‐linked immunosorbent assay (ELISA) to measure changes in the cytokine interleukin‐6 (IL‐6) to determine that inflammation was induced in the mice. Sickness behavior was assessed in a wheel‐running paradigm, and a tail suspension test was used to assess the depressive‐like phenotype that follows sickness behavior in response to LPS.ResultsThe ELISA using blood serum confirmed a significant increase in IL‐6 in mice that were treated with LPS. Treated Fmr1 mutants exhibited decreased distance traveled in the wheel running after LPS administration, similar to treated controls. Another cohort of animals treated with LPS were tested in the tail suspension test and exhibited no alterations in immobility time in response to LPS.ConclusionTogether, our data suggest that Fmr1 mutant mice do not have altered sickness behavior in response to a low dose of LPS.
Alteration of gut microbiome and correlated amino acid metabolism are associated with acute myelocytic leukemia carcinogenesis
Authors: Xu Jing , Kang Yong , Zhong Yan , Ye Wencan , Sheng Tianle , Wang Qingming , Zheng Jifu , Yang Qiuyue , Yi Ping , Li Zhenjiang 
Published: July 2023

AbstractBackgroundThe aim of this study is to investigate the profiles of gut microbiota and metabolites in acute myelocytic leukemia (AML) patients treated with/without chemotherapy.MethodsHerein, high‐throughput 16S rRNA gene sequencing was performed to analysis gut microbiota profiles, and liquid chromatography and mass spectrometry were performed to analysis metabolites profiles. The correlation between gut microbiota biomarkers identified by LEfSe and differentially expressed metabolites were determined by spearman association analysis.ResultsThe results showed the distinguished gut microbiota and metabolites profiles between AML patients and control individuals or AML patients treated with chemotherapy. Compared to normal populations, the ratio of Firmicutes to Bacteroidetes was increased at the phylum level than that in AML patients, and LEfSe analysis identified Collinsella and Coriobacteriaceae as biomarkers of AML patients. Differential metabolite analysis indicated that, compared to AML patients, numerous differential amino acids and analogs could be observed in control individuals and AML patients treated with chemotherapy. Interestingly, spearman association analysis demonstrated that plenty of bacteria biomarkers shows statistical correlations with differentially expressed amino acid metabolites. In addition, we found that both Collinsella and Coriobacteriaceae demonstrate remarkable positive correlation with hydroxyprolyl‐hydroxyproline, prolyl‐tyrosine, and tyrosyl‐proline.ConclusionIn conclusion, our present study investigated the role of the gut‐microbiome–metabolome axis in AML and revealed the possibility of AML treatment by gut‐microbiome–metabolome axis in the further.
Quality‐of‐life, mental health, and perspective on TKI dose reduction as a prelude to discontinuation in chronic phase chronic myeloid leukemia
Authors: Chen Yilin , Xu Na , Yang Yunfan , Liu Zhenfang , Xue Mengxing , Meng Li , He Qun , Chen Chunyan , Zeng Qingshu , Zhu Huanling , Du Xin , Zou Jing , He Wenjun , Guo Jingming , Chen Suning , Yuan Guolin , Wu Hui , Hong Mei , Cheng Fanjun , Liu Bingcheng , Zhang Yanli , Li Weiming 
Published: July 2023

AbstractBackgroundTreatment‐free remission (TFR) has become the main target for chronic myeloid leukemia (CML). Tyrosine kinase inhibitors (TKI) dose optimization is crucial in managing adverse events, and improving adherence in clinical practice. In persons achieving a deep molecular response (DMR), some data suggest TKI dose reduction before discontinuation does not change success rate of achieving TFR, but this is controversial. However, data on quality‐of‐life (QoL) and mental health in CML patients with full‐dose TKI, low‐dose TKI, and TKI discontinuation are limited. Moreover, recent evidence indicating the feasibility of TKI dose reduction and discontinuation after dose reduction, which may change CML patients' perspectives on TKI discontinuation.MethodsWe conducted a cross‐sectional study using online questionnaires to explore the QoL, mental health in patients with diverse TKI dose, and perspective on TKI dose reduction as a prelude to discontinuation.Results1450 responses were included in the analysis. 44.3% of respondents reported a moderate‐to‐severe impact of TKI treatment on their QoL. 17% of respondents had moderate‐to‐severe anxiety. 24.4% of respondents had moderate‐to‐severe depression. In 1326 patients who had not discontinued their medication, 1055 (79.6%) patients reported they would try TKI discontinuation because of concerns over side effects of long‐term medication (67.9%), financial burden (68.7%), poor QoL (77.9%), pregnancy needs (11.6%), anxiety and depression while taking TKI (20.8%), inconvenience of TKI treatment (22.2%). 613 of 817 (75.0%) patients on full‐dose TKI therapy indicated they preferred trying a dose reduction before discontinuing TKI therapy after dose reduction compared with 31 (3.8%) preferring no dose reduction before stopping.ConclusionsTKI dose reduction showed a significant improvement of patients' QoL and mental health, comparable to the effect of TKI discontinuation. Most patients indicated they preferred dose reduction before stopping TKI therapy. In clinical practice, TKI dose reduction can be considered as a bridge from full‐dose treatment to discontinuation.Our results showed that tyrosine kinase inhibitors (TKI) dose reduction showed a significant improvement of patients' quality‐of‐life and mental health, comparable to the effect of TKI discontinuation. Most patients desire to discontinue TKI in the future. TKI discontinuation after dose reduction is more acceptable compared to discontinuing it directly. In clinical practice, TKI dose reduction can be considered as a bridge from full‐dose treatment to discontinuation. Please do not hesitate to contact me in case further clarification is needed with this submission.
Transformational escapes: Accessing consumer transformation through extraordinary experiences
Authors: Scussel Fernanda , Suarez Maribel , Petroll Martin 
Published: July 2023

AbstractPrevious research implies that the transformational potential of extraordinary experiences arises from the engagement with the experiential context, although we still do not know how this process happens and to what extent it changes consumers. In this article, we explore the processes by which consumers transform themselves through extraordinary experiences and the characteristics of such a transformation. Based on a three‐year ethnography in the context of marathon running, we identified the three processes that engender consumer transformation: the physical transformation process, the mental transformation process, and the discursive transformation process. These processes are sheltered by the transformational escape, defined as the consumption setting that integrates structural and antistructural features through the engagement of consumers' routine with the extraordinary experience, enabling consumer transformation. We extend current theorizations by revealing the dynamics that elongate extraordinary experience duration, enable the dynamic between routine and extraordinary experience, and enlarge the reach of consumer transformation.
Nanocarbon in Sodium‐ion Batteries – A Review. Part 1: Zero‐dimensional Carbon Dots
Authors: Thangaraj Baskar , Solomon Pravin Raj , Hassan Jamal 
Published: July 2023

AbstractIn the recent past, sodium‐ion batteries (SIBs) have assumed to be an alternative to lithium‐ion batteries (LIBs) as sodium is abundantly available in nature. It is low cost with its storage mechanism almost similar to LIBs. The ionic radius of Na is three‐fold larger than that of Li and offers a low standard electrochemical potential than Li. The built‐in SIBs are better than LIBs. However, in terms of energy density, specific capacity, and rate capability, there is a lack of suitable anode materials for SIBs. Interestingly, carbon‐based quantum dots are a new class of zero‐dimensional (0D) material with ultra‐small size having unique physicochemical properties. The utility of carbon quantum dots (CQDs), graphene quantum dots (GQDs) and graphitic carbon nitride quantum dots (g‐C3N4 QDs) has drawn attention to the scientists and industrialists for the development of SIBs due to their quantum size and structural diversities, physicochemical properties, amenability for doping with heteroatoms and good electrical conductivity. This article reviews the role of various carbon quantum dots commonly used as anodes in SIBs.
Neighboring‐Group Participation by C‐2 Acyloxy Groups: Influence of the Nucleophile and Acyl Group on the Stereochemical Outcome of Acetal Substitution Reactions
Authors: Chun Yuge , Remmerswaal Wouter A. , Codée Jeroen D. C. , Woerpel K. A. 
Published: July 2023

AbstractA single acyloxy group at C‐2 can control the outcome of nucleophilic substitution reactions of pyran‐derived acetals, but the extent of the neighboring‐group participation depends on a number of factors. We show here that neighboring‐group participation does not necessarily control the stereochemical outcome of acetal substitution reactions with weak nucleophiles. The 1,2‐trans selectivity increased with increasing reactivity of the incoming nucleophile. This trend suggests the intermediacy of both cis‐fused dioxolenium ions and oxocarbenium ions in the stereochemistry‐determining step. In addition, as the electron‐donating ability of the neighboring group decreased, the preference for the 1,2‐trans products increased. Computational studies show how the barriers for the ring‐opening reaction on the dioxolenium ions and the transition states to provide the oxocarbenium ions change with the electron‐donating capacity of the C‐2‐acyloxy group and the reactivity of the nucleophile.
American Radium Society Appropriate Use Criteria for the use of liver‐directed therapies for nonsurgical management of liver metastases: Systematic review and guidelines
Authors: Hallemeier Christopher L. , Sharma Navesh , Anker Christopher , Selfridge J. Eva , Lee Percy , Jabbour Salma , Williams Vonetta , Liu David , Kennedy Timothy , Jethwa Krishan R. , Kim Ed , Kumar Rachit , Small William , Tchelebi Leila , Russo Suzanne 
Published: July 2023

AbstractThe liver is a common site of cancer metastases. Systemic therapy is widely accepted as the standard treatment for liver metastases (LM), although select patients with liver oligometastases may be candidates for potentially curative liver resection. Recent data support the role of nonsurgical local therapies such as ablation, external beam radiotherapy, embolization, and hepatic artery infusion therapy for management of LM. Additionally, for patients with advanced, symptomatic LM, local therapies may provide palliative benefit. The American Radium Society gastrointestinal expert panel, including members representing radiation oncology, interventional radiology, surgical oncology, and medical oncology, performed a systemic review and developed Appropriate Use Criteria for the use of nonsurgical local therapies for LM. Preferred Reporting Items for Systematic reviews and Meta‐Analyses methodology was used. These studies were used to inform the expert panel, which then rated the appropriateness of various treatments in seven representative clinical scenarios through a well‐established consensus methodology (modified Delphi). A summary of recommendations is outlined to guide practitioners on the use of nonsurgical local therapies for patients with LM.
A novel multicarrier index keying‐aided non‐orthogonal multiple access systems in presence of uncertain channel state information
Authors: M. Shwetha H. , Sundru Anuradha 
Published: July 2023

SummaryThis paper investigates the performance of novel multicarrier index keying‐aided non‐orthogonal multiple access (MCIK‐NOMA) system. Unlike the classical scheme, the proposed system sends the information through both index domain and constellation domain symbols thereby increases the spectral efficiency. The impact of channel state information (CSI) uncertainty on the system's performance is investigated. More specifically, the performance of MCIK‐NOMA under three different CSI conditions is analyzed: perfect CSI, MMSE‐based variable CSI, and fixed CSI uncertainty. This paper also discusses the optimum power difference needed for the successful separation of symbols at the SIC receiver by alternating the power ratio in the proposed system. The influence of selecting different active subcarriers and modulation techniques on the system's performance is studied in detail. The simulation results show that the proposed system achieves better BER and spectral efficiency and outperforms the existing systems.
Dynamical BLUP modeling of reaction norm evolution, accommodating changing environments, overlapping generations, and multivariate data
Authors: Ergon Rolf 
Published: July 2023

AbstractFor theoretical studies, reaction norm evolution in a changing environment can be modeled by means of the multivariate breeder's equation, with the reaction norm parameters treated as traits in their own right. This is, however, not a feasible approach for the use of field data, where the intercept and slope values are not available. An alternative approach is to use infinite‐dimensional characters and smooth covariance function estimates found by, e.g., random regression. This is difficult because of the need to find, for example, polynomial basis functions that fit the data reasonably well over time, and because reaction norms in multivariate cases are correlated, such that they cannot be modeled independently. Here, I present an alternative approach based on a multivariate linear mixed model of any order, with dynamical incidence and residual covariance matrices that reflect the changing environment. From such a mixed model follows a dynamical BLUP model for the estimation of the individual reaction norm parameter values at any given parent generation, and for updating of the mean reaction norm parameter values from generation to generation by means of Robertson's secondary theorem of natural selection. This will, for example, make it possible to disentangle the microevolutionary and plasticity components in climate change responses. The BLUP model incorporates the additive genetic relationship matrix in the usual way, and overlapping generations can easily be accommodated. Additive genetic and environmental model parameters are assumed to be known and constant, but it is discussed how they can be estimated by means of a prediction error method. The identifiability by the use of field or laboratory data containing environmental, phenotypic, fitness, and additive genetic relationship data is an important feature of the proposed model.