bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of sleep quality and depressive symptoms among medical students during COVID-19 pandemic
Authors: Samadi Shahram , Amirifard Hamed , Eslami Mohammad , Khadembashiri Mohammad Amin , Khadembashiri Mohammad Mehdi , Najafi Anahita 
Published: September 2023

Abstract
Background
Depression and sleep disorders are interrelated and have high prevalence. Based on previous findings, medical students experience high rates of depression and low sleep quality, due to the challenges during medical training programs. During the COVID-19 pandemic, medical students faced extra physical and psychological pressure. This study aimed to evaluate sleep quality and depressive symptoms and their possible association among medical students during COVID-19 pandemic.

Results
One hundred twenty-one medical students completed the survey. Twenty-six percent of participants had a good sleep quality. Mean sleep duration of participants was approximately 6 h per day. Moreover, they had a mean sleep latency of 28 min and a mean PSQI score of 7.76. We found the prevalence of moderate, moderately severe, and severe depression among participants to be 22%, 6%, and 7%, respectively. The participants’ mean PHQ-9 score was found to be 8.4.

Conclusions
We found a relatively high depression rate, poor sleep quality, and a significant inverse relationship between sleep quality and depression severity score among medical students who were doing their clinical rotations during the COVID-19 pandemic. Additionally, quarter of moderate to severely depressed participants were taking antidepressants. Our findings highlight the need for future interventional studies that address these issues among medical students.
Bilateral congenital cholesteatoma: a case report
Authors: Nourizadeh Navid , Afzalzadeh Mohamad Reza , Rashed Masoud Mahdavi 
Published: September 2023

Abstract
Background
Cholesteatoma is regarded as a critical health issue in the world. Nevertheless, congenital cholesteatoma (CC) is an unusual problem, and bilateral CC is extremely rare.

Case presentation
The present work reports a young boy with conductive hearing loss because of CC. The left side was operated using a canal-wall-down mastoidectomy method for immense destruction of the middle ear structures and mastoid air cells, and endoscopic ear surgery was performed on the second side.

Conclusion
Although CC is very rare, it should be considered in the differential diagnosis of hearing loss in children. Moreover, it should be carefully followed up because it can probably occur on the second side.
Discovering social determinants of health from case reports using natural language processing: algorithmic development and validation
Authors: Raza Shaina , Dolatabadi Elham , Ondrusek Nancy , Rosella Laura , Schwartz Brian 
Published: September 2023

Abstract
Background
Social determinants of health are non-medical factors that influence health outcomes (SDOH). There is a wealth of SDOH information available in electronic health records, clinical reports, and social media data, usually in free text format. Extracting key information from free text poses a significant challenge and necessitates the use of natural language processing (NLP) techniques to extract key information.

Objective
The objective of this research is to advance the automatic extraction of SDOH from clinical texts.

Setting and data
The case reports of COVID-19 patients from the published literature are curated to create a corpus. A portion of the data is annotated by experts to create ground truth labels, and semi-supervised learning method is used for corpus re-annotation.

Methods
An NLP framework is developed and tested to extract SDOH from the free texts. A two-way evaluation method is used to assess the quantity and quality of the methods.

Results
The proposed NER implementation achieves an accuracy (F1-score) of 92.98% on our test set and generalizes well on benchmark data. A careful analysis of case examples demonstrates the superiority of the proposed approach in correctly classifying the named entities.

Conclusions
NLP can be used to extract key information, such as SDOH factors from free texts. A more accurate understanding of SDOH is needed to further improve healthcare outcomes.
HERTHENA-Lung01, a Phase II Trial of Patritumab Deruxtecan (HER3-DXd) in Epidermal Growth Factor Receptor–Mutated Non–Small-Cell Lung Cancer After Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Therapy and Platinum-Based Chemotherapy
Authors: Yu Helena A. , Goto Yasushi , Hayashi Hidetoshi , Felip Enriqueta , Chih-Hsin Yang James , Reck Martin , Yoh Kiyotaka , Lee Se-Hoon , Paz-Ares Luis , Besse Benjamin , Bironzo Paolo , Kim Dong-Wan , Johnson Melissa L. , Wu Yi-Long , John Thomas , Kao Steven , Kozuki Toshiyuki , Massarelli Erminia , Patel Jyoti , Smit Egbert , Reckamp Karen L. , Dong Qian , Shrestha Pomy , Fan Pang-Dian , Patel Parul , Sporchia Andrea , Sternberg David W. , Sellami Dalila , Jänne Pasi A. 
Published: September 2023

PURPOSE Patritumab deruxtecan, or HER3-DXd, is an antibody-drug conjugate consisting of a fully human monoclonal antibody to human epidermal growth factor receptor 3 (HER3) attached to a topoisomerase I inhibitor payload via a stable tetrapeptide-based cleavable linker. We assessed the efficacy and safety of HER3-DXd in patients with epidermal growth factor receptor ( EGFR)–mutated non–small-cell lung cancer (NSCLC). METHODS This phase II study (ClinicalTrials.gov identifier: NCT04619004 ) was designed to evaluate HER3-DXd in patients with advanced EGFR-mutated NSCLC previously treated with EGFR tyrosine kinase inhibitor (TKI) therapy and platinum-based chemotherapy (PBC). Patients received HER3-DXd 5.6 mg/kg intravenously once every 3 weeks or an uptitration regimen (3.2 → 4.8 → 6.4 mg/kg). The primary end point was confirmed objective response rate (ORR; RECIST 1.1) by blinded independent central review (BICR), with a null hypothesis of 26.4% on the basis of historical data. RESULTS Enrollment into the uptitration arm closed early on the basis of a prespecified benefit-risk assessment of data from the phase I U31402-A-U102 trial. In total, 225 patients received HER3-DXd 5.6 mg/kg once every 3 weeks. As of May 18, 2023, median study duration was 18.9 (range, 14.9-27.5) months. Confirmed ORR by BICR was 29.8% (95% CI, 23.9 to 36.2); median duration of response, 6.4 months; median progression-free survival, 5.5 months; and median overall survival, 11.9 months. The subgroup of patients with previous osimertinib and PBC had similar outcomes. Efficacy was observed across a broad range of pretreatment tumor HER3 membrane expression levels and across diverse mechanisms of EGFR TKI resistance. In patients with nonirradiated brain metastases at baseline (n = 30), the confirmed CNS ORR by BICR per CNS RECIST was 33.3% (95% CI, 17.3 to 52.8). The safety profile (National Cancer Institute Common Terminology Criteria for Adverse Events v5.0) was manageable and tolerable, consistent with previous observations. CONCLUSION After tumor progression with EGFR TKI therapy and PBC in patients with EGFR-mutated NSCLC, HER3-DXd once every 3 weeks demonstrated clinically meaningful efficacy with durable responses, including in CNS metastases. A phase III trial in EGFR-mutated NSCLC after progression on an EGFR TKI is ongoing (HERTHENA-Lung02; ClinicalTrials.gov identifier: NCT05338970 ).
Progress Toward and Challenges Remaining for Thyroid Tissue Regeneration
Authors: Romitti Mírian , Costagliola Sabine 
Published: September 2023

Abstract
Thyroid hormones play a pivotal role in diverse physiological processes, and insufficient synthesis of these hormones results in hypothyroidism, a prevalent disorder with a significant global impact. Research has shown that the residual thyroid tissue following surgery fails to fully regenerate the gland and restore normal function. The slow turnover rate of the thyroid gland and the presence of resident stem cells, which may contribute to regeneration within adult thyroid tissue, are topics of ongoing debate. This comprehensive review summarizes current research findings concerning the regeneration of the adult thyroid. Investigations have identified potential cellular mechanisms implicated in thyroid regeneration following partial tissue damage, including cells within microfollicles and a cluster of potential thyroid progenitors cells. Nevertheless, the exact mechanisms remain elusive. In cases of complete removal of the thyroid gland, regeneration does not occur, underscoring the necessity for an external source of thyroid tissue. The transplantation of thyroid organoids has emerged as a promising approach to restore thyroid function. Researchers have successfully derived thyroid organoids from various sources and demonstrated their functionality in both in vitro and in vivo animal models. Despite the challenges that still need to be addressed in achieving full maturation and functionality of human thyroid organoids, significant strides have been made in this regard. This review explores the potential of thyroid organoid transplantation and its implications for the field of regenerative medicine.
Role of nutrition management in the treatment of acute pancreatitis – comprehensive review
Authors: Kazzi Marcel , Bieniasz Jan , Dendys Konrad , Puła Michał , Wychota Marta 
Published: September 2023

Introduction and purpose
The treatment of acute pancreatitis remains a clinically significant problem worldwide, as well as in Poland, where the incidence of the condition is nearly twice as high as in the global population. The aim of this study is to present the latest available guidelines regarding conservative management of patients diagnosed with acute pancreatitis, focusing on nutritional management and treatment methods.

Materials and methods:
The literature available in PubMed, Scopus, Google Scholar databases, and guidelines from the European Society for Clinical Nutrition and Metabolism (ESPEN) was reviewed using the following keywords: "acute pancreatitis," "AP treatment," "nutritional treatment of acute pancreatitis," "enteral nutrition," "parenteral nutrition."

Description of the state of knowledge:
The approach to conservative treatment for acute pancreatitis has evolved over the years. Previously, the preferred route of feeding was parenteral with limited lipid content, aimed at reducing the stress on the pancreas. Current guidelines emphasize the superiority of enteral nutrition using a complete nutritional composition.

Conclusions:
The latest guidelines highlight the advantage of enteral nutrition over parenteral nutrition, with implementation within 48 hours of diagnosis. This approach reduces mortality, the risk of complications, and the duration of hospital stay for patients. The appropriate caloric intake should be adjusted to the individual needs of the patient, considering the severity of the disease and coexisting conditions. Meeting the patient's energy requirements, along with the choice of administration method and precise composition of nutritional formulas, play a crucial role in therapy.
Halkbilimsel Metaetik Kuram ile Âşık Tarzı Kültür Geleneğinde Sistematik ve Zincirleme Molekül Etik Değerlerin Yapısı
Authors: ÇOBANOĞLU Sacide 
Published: September 2023

Günümüzde ulaşılan teknoloji, hayatı kolaylaştırdığı ölçüde toplumların etik anlayışında olumsuz değişikliklere neden olmaktadır. Bugün dünya, kültürel yozlaşma sebebiyle gelir dağılımındaki adaletsizlik başta olmak üzere savaşlar, yoksulluğun küreselleşmesi, sağlık hizmetlerindeki yetersizlik, terör, ekolojik sorunlar, yapay zeka kullanımının getireceği problemler, çocuk/kadın/hayvan haklarındaki adaletsizlik gibi birçok etik sorunuyla karşı karşıyadır. Etik problemlerinin çözümünde her toplum; mitolojik arka planı, tarihi alt yapısı gelenek, görenekleriyle oluşturduğu halk felsefesinden faydalanacaktır. Bu noktada Türk halk felsefesini tanımlayan kaynakların başında halk edebiyatımız ve halk şairlerimizin ürünleri gelmektedir. Bu ürünler arasında Kazak Abdal’ın taşlamaları, döneminin zihniyetini aşarak evrensel etik anlayış çizgisinde, Türk halk felsefesinin temel unsurlarını temsil etmek bakımından dikkat çekicidir. Etik değerler toplumların dünya görüşünü ifade etmektedirler. Bir etik değerin, kendisiyle bağlantılı olan etik eylemlerden ve molekül etik değerlerden bağımsız olarak yorumlanması mümkün değildir.
Bu çalışmanın konusu; etik problemlerinin bir sistem dahilinde çözülmesini sağlayan kuramımız Halkbilimsel Metaetik Kuram ile taşlamalardaki etik değerlerin bağlamsal moleküllerini ve Türk halk felsefesindeki yerini ortaya koymak suretiyle günümüz etik problemlerine çözüm getirmeye çalışmaktır. Çalışmamız âşık tarzı kültür geleneğinde, etik değerlerin bağlamsal molekülleriyle yapılanan halk felsefesini farklı bir bakış açısıyla incelemek amacını taşımaktadır.
Eco Soma: Pain and Joy in Speculative Performance Encounters, Petra Kuppers (2022)
Authors: Laurence Miranda 
Published: September 2023

Review of: Eco Soma: Pain and Joy in Speculative Performance Encounters, Petra Kuppers (2022)
Minneapolis, MN: University of Minnesota Press, 280 pp.,
ISBN 978-1-45296-687-8, e-book, open access
A Philosophy of Practising With Deleuze’s Difference and Repetition, Antonia Pont (2021)
Authors: Shaw Oliver 
Published: September 2023

Review of: A Philosophy of Practising With Deleuze’s Difference and Repetition, Antonia Pont (2021)
Edinburgh: Edinburgh University Press, 230 pp.,
ISBN 978-1-47449-046-7, h/bk, £75.00
A taxonomic review of the genus Ocimum L. (Ocimeae, Lamiaceae)
Authors: Mamita Kalita  , Devi Nilakshee 
Published: September 2023

The plants of the genus Ocimum L. are rejuvenating herbs due to their aesthetic and magnanimous healing nature. Ocimum L. is a pivot of modern research such as phytochemistry, molecular and medicinal biology. However, there needs to be more taxonomic interpretation and identification of the genus, summing up the need for our study. The morphological discrepancies and nomenclature of Ocimum L. are jumbled up, the same species has been named multiple times by multiple authors. It culminates in erroneous evaluation for taxonomy-based research. Our indignation highlights the taxonomic alterations and modifications that Ocimum L. has undergone since primeval period. The genus's classical to the modern taxonomic transition has not been studied hitherto. The aim is to provide precise information on the antecedent and contemporary stature of Ocimum L. The present study attempts to provide taxonomic clarity for a highly economic genus in order to enhance the commercial perspective and efficiency of selective breeding practices. The present study emphasizes identifying samples with their type, protologue, and herbarium specimen and extricate between ecotype, morphotype, and chemotypes. Molecular taxonomy can provide better insights and transparency. But for a better exposition, such studies must revolve around correctly identified species. The selection of representatives from different populations of the same species can help understand the consistency of vegetative and reproductive characteristics. In this review, few corrections have been provided for misidentified or mistaken species. The species with incorrect nomenclature has been identified and corrections have been suggested. For a better understanding, habit photographs of Indian Ocimum L. have been furnished and morphological features (vegetative and reproductive) for proper diagnosis and correlation has been provided. Specimen examination either through physical or digital herbaria is an obligatory criterion for an error-free taxonomic inquest. Our findings will help to achieve accuracy while interpreting the genus and its species. The retrospection will aid in floristic, biodiversity, taxonomic, phylogenetic, biochemistry and molecular systematic related works. The observations will apprehend the existing gap concerning the taxonomy of Ocimum L.
Integration E-Learning Tools in Teaching and Learning English Language: Literature Review
Authors: Alshahrani Nada 
Published: September 2023

This paper as a literature reviews, its primary goal is to examine the effect of the employment of E-Learning tools technology in teaching and learning English language. The English language play an important and crucial role in education environment. As a result, it is an essential for students to acquire a good understanding in education environment. Using traditional style in delivering information to learners might not assist and expand their English skills. Integration new technology in teaching and learning English language is a good technique that can help learners to acquire information quickly. Hence, this research the impact of the adoption of e-learning tools in teaching and learning English language. Also, this paper will provide some recommendations and suggestions for the future work.
Pengaruh Metode Latihan Plyometric Vertical, Horizontal dan Kekuatan Otot Perut Terhadap Peningkatan Lompat Jauh di Kabupaten Kendal
Authors: Salamah Dina Yuni 
Published: September 2023

The coaching is carried out routinely and structured, with the methods applied by the coach, the results of initial observations show that the jumps of PASI athletes in Kendal Regency, 8 athletes have 4 meters jumps and 11 athletes have less than 4 meters jumps. Therefore, programmed training is needed to improve the jumping ability of PASI athletes in Kendal Regency. The purpose of this study was to determine the effect of vertical, horizontal plyometric training methods and abdominal muscle strength on increasing the long jump in Kendal Regency. The sample in this study were 20 athletes from PASI Kendal Regency. The sampling technique used was total sampling technique while the data analysis technique used was statistical analysis technique using SPSS data statistical analysis assistance. The result of increasing the plyometric training method is 5.63% lower than the result of increasing the abdominal muscle strengthening exercise of 11.52%.
The coaching is carried out routinely and structured, with the methods applied by the coach, the results of initial observations show that the jumps of PASI athletes in Kendal Regency, 8 athletes have 4 meters jumps and 11 athletes have less than 4 meters jumps. Therefore, programmed training is needed to improve the jumping ability of PASI athletes in Kendal Regency. The purpose of this study was to determine the effect of vertical, horizontal plyometric training methods and abdominal muscle strength on increasing the long jump in Kendal Regency. The sample in this study were 20 athletes from PASI Kendal Regency. The sampling technique used was total sampling technique while the data analysis technique used was statistical analysis technique using SPSS data statistical analysis assistance. The result of increasing the plyometric training method is 5.63% lower than the result of increasing the abdominal muscle strengthening exercise of 11.52%.
A Comparative Study of Basic Science Process Skills of Science Students at Higher Secondary Level in District Rawalpindi, Pakistan
Authors: Ahmed M. , Choudhary F. R. , Sultan S. 
Published: September 2023

Science process skills (SPS) had a pivotal role in scientific investigation. SPS are very important to be developed in science learning because with the help of SPS students develop their thoughts to make discoveries using scientific investigation. In the 21st century SPS are needed in science learning. In Pakistan results of many studies showed that private sector institutes’ students were performing better than the public sector institutes’ students in the subject of science. Better performance in science is only possible when students have a high level of science process skills. The main purpose of this study was to determine students’ level of performance on basic science process skill and to compare the performance of public and private school Physics students in science process skills at the H.S.S.C. level. A Simple comparative research design was used to compare the skill level of students. In the present study four aspects, of basic science process skills (Observation, Communication, Measurement, and Relationship) were observed. Through purposive sampling technique two top-level colleges, one from the public school system and one from the private school system of the city of Rawalpindi, were selected for the study. For data collection researcher used an observation sheet and worksheet based on four experiments of physics at higher secondary school certificate level. Measurement of SPS was done when students were performing experiments in practical labs. t-test was employed to compare the performance of public and private school students. The result of the research stated that there was a significant difference in basic science process skills of public and private school physics students at the H.S.S.C level. The mean score of performance of public and private school students was observed to be good in the aspects of observation and relationship skills but still teachers need to improve the performance of students in the aspects of communication and measurement skills. Further it is recommended that exam system may give more weightage to science process skills so that students and teacher of science subjects may be able to concentrate more on this aspect of learning.
Differences in the Triplechem Learning Model with Balinese Local Wisdom and the Discovery Learning Model in Influencing Students' Visual Literacy and Mental Models about Acid-Base Solutions
Authors: Suja I. W. , Jayadiningrat I. M. G. , Ardiyasa I. N. S. 
Published: September 2023

This study intends to investigate the differences in the effect of the TripleChem learning model with Balinese local wisdom and the Discovery Learning model on students' visual literacy and chemical mental models about acid-base solutions. The research was designed using a quantitative approach and classified as quasi-experimental. The research design used was a pretest-posttest non-equivalent control group design. The population of this study was 206 junior high school students with Balinese cultural backgrounds with various beliefs (religions), namely Hindus, Muslims, and Christians. Cultural content will cause learning to be more contextual, more interesting, and bring students closer to their own culture. The sampling was done using a simple random sampling technique, and obtained two sample classes, one class as the experimental group, and the other as the control group. The experimental group was taught using the TripleChem learning model containing Balinese local wisdom, while the control group was taught using the Discovery Learning model. The dependent variable in this research was visual literacy and students' mental models of chemistry. Data collection was carried out using a visual literacy test (10 items in total; item validity between 0.520 – 0.893; and test reliability coefficient of 0.895) and a chemical mental model test (8 items in total; item validity between 0.669 – 0.878; and test reliability coefficient of 0.922). Data analysis was carried out descriptively and MANCOVA. The results show that the TripleChem learning model is more effective to be applied to improve students' visual literacy and mental models about acid-base solutions compared to the Discovery Learning model. This condition is caused by the syntax of the TripleChem learning model which is more sequential and structured to build students' visual literacy and chemistry mental models. The application of the TripleChem learning model in chemistry learning needs to be supported by laboratory facilities to display chemical macroscopic phenomena and animated media to explain these phenomena at the level of matter particles.