bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sensitive Detection of p‐Chlorobenzaldehyde in Environmental Water Based on Au@Ag‐MOFs Nanoparticle by Surface‐Enhanced Raman Scattering
Authors: Li Yuanting , Zhang Mengmeng , Wu Zhouya , Bao Xiaoli 
Published: January 2023

AbstractSurface enhanced Raman scattering (SERS) is difficult to detect molecules with weak adsorption, like aldehydes. Herein, we fabricated core‐shell Au@Ag‐MOFs nanoparticles as SERS substrate. The shell can be controllably synthesized, with the thickness about 3 nm. After the morphology and SERS activity characterization, Au@Ag‐MOFs were employed to sensitive and label‐free detect p‐chlorobenzaldehyde (PCB) in water samples. The pore structure and large surface area of Ag‐MOFs shell results more adsorption of PCB, dragging more molecules to “hot spots” area. The abundant amino group in Ag‐MOFs allows the occurrence of Schiff base reaction with aldehyde group in PCB. Taking the synergistic effect of both physical and chemical enhancement, SERS signals of PCB were greatly boosted. The method showed good linearity between 5.0×10−12 M to 1.0×10−8 M for PCB with the limit of detection (LOD) down to 3.3×10−12 M. The proposed method has great potential to be a reliable analytical strategy for aldehydes in real samples.
Coumarin C−H Functionalization by Mn(I) Carbonyls: Mechanistic Insight by Ultra‐Fast IR Spectroscopic Analysis
Authors: Burden Thomas J. , Fernandez Kathryn P. R. , Kagoro Mary , Eastwood Jonathan B. , Tanner Theo F. N. , Whitwood Adrian C. , Clark Ian P. , Towrie Michael , Krieger Jean‐Philippe , Lynam Jason M. , Fairlamb Ian J. S. 
Published: January 2023

AbstractMn(I) C−H functionalization of coumarins provides a versatile and practical method for the rapid assembly of fused polycyclic pyridinium‐containing coumarins in a regioselective manner. The synthetic strategy enables application of bench‐stable organomanganese reagents in bothphotochemical‐andthermal‐promoted reactions. The cyclomanganated intermediates, and global reaction system, provide an ideal testing ground for structural characterization of the active Mn(I) carbonyl‐containing species, including transient species observable by ultra‐fast time‐resolved spectroscopic methods. The thermodynamic reductive elimination product, solely encountered from reaction between alkynes and air‐stable organometallic cyclomanganated coumarins, has enabled characterization of a critical seven‐membered Mn(I) intermediate, detected by time‐resolved infrared spectroscopy, enabling the elucidation of the temporal profile of key steps in the reductive elimination pathway. Quantitative data are provided. Manganated polycyclic products are readily decomplexed by AgBF4, opening‐up an efficient route to the formation of π‐extended hybrid coumarin‐pyridinium compounds.
The optimal design of 3D‐printed lattice bone plate by considering fracture healing mechanism
Authors: Xu Shipeng , Ding Xiaohong , Xiong Min , Duan Pengyun , Zhang Heng , Li Zhuoyi 
Published: January 2023

AbstractThe biomechanical stimulus is the most important factor for fracture healing and mainly determined by the structural stiffness of bone plate. Currently, the materials commonly used in bone plates are stainless steel and titanium, which often lead to stress shielding effects because of their higher elastic modulus compared with the bone. This article suggests an optimal design method of lattice bone plate based on fracture healing theory. First, the mechanical regulation model with deviatoric strain is established to simulate the tissue differentiation process during fracture healing process. The ratio of the average elastic modulus of callus at the 120th day to the elastic modulus of mature bone is used to characterize the fracture healing rate. Second, the optimal elastic modulus of the design domain is obtained by the optimization mathematical model with the maximum fracture healing rate. Then, the design domain is filled with microstructures, the porosity of which is adjusted to make it possible that the equivalent elastic modulus is equal to the optimized value. And the finite element analysis of the bone plate with microstructure is executed. Finally, the designed lattice bone plates are manufactured through 3D printing, and the mechanical test is carried out. The simulation results indicate that the fracture healing rate is maximum when the elastic modulus of material in design domain is 38 GPa under the constraints of fixation stability. And both the finite element analysis and experiment results show that the designed lattice bone plate meet the strength requirements of fracture internal fixation implants.
Self‐attention based progressive generative adversarial network optimized with arithmetic optimization algorithm for kidney stone detection
Authors: V. Brindha Devi , K. Johny Elma , S. Rooban , Shajin Francis H. 
Published: January 2023

SummarySelf‐attention based progressive generative adversarial network optimized with arithmetic optimization algorithm (AOA) is proposed in this manuscript for kidney stone detection. Initially, the input kidney stone images are gathered via CT kidney dataset. Then, the input image is preprocessed by utilizing APPDRC filtering approach. Also, the preprocessed images are given to the multi‐level thresholding segmentation technique for segmented the image. Then the segmented images are given to the TF‐IDF feature extraction method for extracting the features. Then the extracted features are fed to feature selection using Weibull distributive generalized multidimensional scaling methods for selecting the features. Then the selected features are SPGGAN classification method for kidney stone detection. Generally, SPGGAN not reveal any adoption of optimization methods compute optimum parameters for assuring correct kidney stone detection. Thus, AOA is used for optimizing the weight parameters of SPGGAN and it is implemented in python, its performance is examined under certain performances metrics, such as accuracy, precision, sensitivity, specificity, F‐measure, computational time, and ROC. The proposed SPGGAN‐AOA‐KSD method attains 54.78%, 34.89%, and 20.96% higher accuracy and 3.45%, 4.08%, and 5.06% greater AUC compared with existing methods, such as a ANN‐OGGA‐KSD, HMANN‐BPA‐KSD, and ANN‐CSOA‐KSD respectively.
HMDE‐FS: A homogeneous distributed ensemble feature selection framework based on resampling with/without replacement
Authors: Nosrati Vahid , Rahmani Mohsen 
Published: January 2023

SummaryApplying ensemble feature selection (EFS) models in various problems has not been actively discussed, and there has been a lack of effort to make it applicable in the situations such as distributed environments. Due to restrictions of centralized algorithms such as their poor scalability in the high dimension data and also distributed nature of some data, using the traditional centralized computing for dealing with such problems may be inevitable. This paper aims to develop a homogenous distributed ensemble feature selection (HMDE‐FS) framework through a distributed resampling approach rather than a centralized one. The homogenous ensembles mainly operate along with a resampling process, so applying various methods to resampling can affect the performance of the model. Among various strategies, those with and without replacement are two of the main technique families, hence we investigated the efficiency of two well‐known with/without replacement techniques: bootstrapping (BS) and cross‐validation (CV) inspired method that we named crisscross (CC). The proposed HMDE‐FS approaches are tested on eight datasets, and the heavy experimental results illustrate that these methods considerably reduce runtime, while classification accuracy maintains its competitiveness.
A review of computational modeling, machine learning and image analysis in cancer metastasis dynamics
Authors: Hirway Shreyas U. , Weinberg Seth H. 
Published: January 2023

AbstractCancer is a life‐threatening process that stems from genetic mutations in cells, which leads to the formation of tumors, and is a major cause of deaths in the United States, with secondary metastasis being a major driver of fatality. The development of an optimal metastatic environment is an essential process prior to tumor metastasis. This process, called pre‐metastatic niche formation, involves the activation of resident fibroblast‐like cells and macrophages. Tumor‐mediated factors introduced to this environment transform resident cells that secrete additional growth factors and remodel the extracellular matrix, which is thought to promote tumor colonization and metastasis in the secondary environment. Furthermore, an important component of metastasis is the biological process of epithelial–mesenchymal transition, which can be exploited by cancer cells to change their phenotype, to migrate and proliferate as necessary. In this review, we discuss recent advances in the investigation of cancer growth and migration. Computational models that focus on biochemical signaling and multicellular dynamics are examined. Machine learning models and image analysis that classify cancer‐related data are also explored. Through this review, we highlight advances in the study of important aspects of cancer and metastasis signaling and computational tools to study these dynamics.
Model‐based estimation in monetary policy inertia and it's another possibility
Authors: Cha H. E. , Lim Raymond Jay 
Published: January 2023

AbstractIn this paper, different monetary policy rules are re‐estimated employing real‐time data, known as Greenbook data, through MLE and Bayesian Estimation. The results favour the rule with persistent shocks and show that the inertial movement of the Federal funds rate is an illusion, as mentioned by Rudebusch (2002). Since it would be possible to have an omitted variable bias due to impure serial correlation, however, the rule with persistent shock could imply that the other serially correlated variable is required to explain the inertial movement of Federal funds rates. Based on this idea, serial correlation tests are implemented, showing the possibility of an omitted serial correlated variable. Therefore, it is reasonable to search for other persistent variables. As an illusion implies unpredictability in the movement of the Federal funds rate, this hypothesis could be against the credibility of the central bank. In order to have a reasonable explanation for the inertial movement other than persistent shocks, therefore, modifying the rule with a 3‐month t‐bill rate is re‐estimated. The result shows that the rule with the t‐bill rate outperformed in all aspects and is compatible with one theoretical explanation of minimizing the financial volatility for inertial movement.
Light sheet imaging and interactive analysis of the cardiac structure in neonatal mice
Authors: Sodimu Oluwatofunmi , Almasian Milad , Gan Peiheng , Hassan Sohail , Zhang Xinyuan , Liu Ning , Ding Yichen 
Published: January 2023

AbstractLight‐sheet microscopy (LSM) enables us to strengthen the understanding of cardiac development, injury, and regeneration in mammalian models. This emerging technique decouples laser illumination and fluorescence detection to investigate cardiac micro‐structure and function with a high spatial resolution while minimizing photodamage and maximizing penetration depth. To unravel the potential of volumetric imaging in cardiac development and repair, we sought to integrate our in‐house LSM, Adipo‐Clear, and virtual reality (VR) with neonatal mouse hearts. We demonstrate the use of Adipo‐Clear to render mouse hearts transparent, the development of our in‐house LSM to capture the myocardial architecture within the intact heart, and the integration of VR to explore, measure, and assess regions of interests in an interactive manner. Collectively, we have established an innovative and holistic strategy for image acquisition and interpretation, providing an entry point to assess myocardial micro‐architecture throughout the entire mammalian heart for the understanding of cardiac morphogenesis.
Frequent coexistence of early repolarization pattern, J‐point elevation, and high Sokolow‐Lyon voltage in young men
Authors: Saito Nagomi , Nagahara Daigo , Kamiyama Naoyuki , Fujito Takefumi , Koyama Masayuki , Mochizuki Atsushi , Yano Toshiyuki , Takahashi Satoshi 
Published: January 2023

AbstractBackgroundEarlier studies have shown male dominance of an early repolarization (ER) pattern and frequent coexistence with high Sokolow‐Lyon voltage. Although possible involvement of androgen is speculated, the underlying mechanism has not been clarified yet. Previous studies were conducted in adult populations or only in children, and there has been no study in which the ER pattern was investigated in a series of individuals ranging from children before puberty to adults.MethodsWe included 600 individuals comprising six groups according to age: 10–14 years old, 15–19 years old, twenties, thirties, forties, and fifties. Each group had 50 males and 50 females. The distribution of an ER pattern and related ECG parameters were assessed by age and gender.ResultsIn early teenagers, there was no significant gender difference in the prevalence of an ER pattern (24% in men vs. 28% in women, p = .82). The prevalence of an ER pattern increased after puberty and reached a peak in men in their twenties (42%). With further advance of age, the prevalence of an ER pattern decreased. On the other hand, the prevalence of an ER pattern in women peaked at 28% in teenagers, and it decreased through twenties (20%) to thirties (10%). Similar male dominance after puberty was observed in Sokolow‐Lyon voltage and J‐point elevation but not in P‐wave amplitude.ConclusionThe prevalence of an ER pattern, Sokolow‐Lyon voltage, and J‐point elevation are all augmented after puberty and decrease with aging, leading to frequent coexistence of these ECG findings in young men.
Ranking and selection for pairwise comparison
Authors: Xiao Hui , Zhang Yao , Kou Gang , Zhang Si , Branke Juergen 
Published: January 2023

AbstractIn many real‐world applications, designs can only be evaluated pairwise, relative to each other. Nevertheless, in the simulation literature, almost all the ranking and selection procedures are developed based on the individual performances of each design. This research considers the statistical ranking and selection problem when the design performance can only be simulated pairwise. We formulate this new problem using the optimal computing budget allocation approach and derive the asymptotic optimality condition based on some approximations. The numerical study indicates that our approach can reduce the number of simulations required to confidently identify the best design.
Towards an integrated radiofrequency safety concept for implant carriers in MRI based on sensor‐equipped implants and parallel transmission
Authors: Petzold Johannes , Schmitter Sebastian , Silemek Berk , Winter Lukas , Speck Oliver , Ittermann Bernd , Seifert Frank 
Published: January 2023

AbstractTo protect implant carriers in MRI from excessive radiofrequency (RF) heating it has previously been suggested to assess that hazard via sensors on the implant. Other work recommended parallel transmission (pTx) to actively mitigate implant‐related heating. Here, both ideas are integrated into one comprehensive safety concept where native pTx safety (without implant) is ensured by state‐of‐the‐art field simulations and the implant‐specific hazard is quantified in situ using physical sensors. The concept is demonstrated by electromagnetic simulations performed on a human voxel model with a simplified spinal‐cord implant in an eight‐channel pTx body coil at
. To integrate implant and native safety, the sensor signal must be calibrated in terms of an established safety metric (e.g., specific absorption rate [SAR]). Virtual experiments show that
‐field and implant‐current sensors are well suited for this purpose, while temperature sensors require some caution, and
probes are inadequate. Based on an implant sensor matrix
, constructed in situ from sensor readings, and precomputed native SAR limits, a vector space of safe RF excitations is determined where both global (native) and local (implant‐related) safety requirements are satisfied. Within this safe‐excitation subspace, the solution with the best image quality in terms of
magnitude and homogeneity is then found by a straightforward optimization algorithm. In the investigated example, the optimized pTx shim provides a 3‐fold higher
magnitude compared with circularly polarized excitation for a maximum implant‐related temperature increase
.To date, sensor‐equipped implants interfaced to a pTx scanner exist as demonstrator items in research labs, but commercial devices are not yet within sight. This paper aims to demonstrate the significant benefits of such an approach and how this could impact implant‐related RF safety in MRI. Today, the responsibility for safe implant scanning lies with the implant manufacturer and the MRI operator; within the sensor concept, the MRI manufacturer would assume much of the operator's current responsibility.
Synthesis of Functionalized 2‐Oxo‐2H‐benzo[h]chromene‐3‐carbonitriles from 1‐Tetralones
Authors: Ghatak Trisha , Althagafi Ismail , Chahal Mohit , Nath Mahendra , Pratap Ramendra 
Published: January 2023

AbstractWe have developed a facile oxidative approach for the synthesis of C‐4 functionalized 2‐oxo‐2H‐benzo[h]chromenes. The required precursors, 4‐(methylthio)‐2‐oxo‐5,6‐dihydro‐benzo[h]chromenes were synthesized by reaction of 1‐tetralones and 2‐cyano‐3,3‐bis(methylthio)acrylate under basic conditions, which can be further aminated with different secondary amines in refluxing ethanol. We have reported the NBS and AIBN mediated oxidation of 5,6‐dihydro‐benzo[h]chromenes to afford 4‐(substituted)‐2‐oxo‐benzo[h]chromenes. The scope of dehydrohalogenation was further extended for the synthesis of thiophene‐fused chromenes. Reactivity of synthesized 4‐(substituted)‐2‐oxo‐benzo[h]chromenes was also explored with C‐ and S‐nucleophiles.
circFLNA promotes intestinal injury during abdominal sepsis through Fas-mediated apoptosis pathway by sponging miR-766-3p
Authors: Ye Ling , Shi Yuan , Zhang Huifeng , Chen Chao , Niu Jingjing , Yang Jianxu , Li Zhifeng , Shao Huanzhang , Qin Bingyu 
Published: January 2023

Abstract
Background
Intra-abdominal infections are the second most common cause of sepsis in the intensive care unit. Intestinal epithelial injury due to abdominal sepsis results in a variety of pathological changes, such as intestinal bacteria and toxins entering the blood, leading to persistent systemic inflammation and multiple organ dysfunction. The increased apoptosis of intestinal epithelial cells induced by sepsis further exacerbates the progression of sepsis. Although several studies have revealed that circRNAs are involved in intestinal epithelial injury in sepsis, few studies have identified the roles of circRNAs in intestinal epithelial apoptosis.

Methods
We used laser capture microdissection to obtain purified epithelial cells located in intestinal crypts from four patients with abdominal sepsis induced by intestinal perforation and four samples from age and sex-matched non-septic patients. Microarray analysis of circRNAs was conducted to assess differentially expressed circRNAs between patients with and without sepsis. Lastly, in vitro and in vivo assays were performed to study the mechanism of circFLNA in intestinal epithelial apoptosis during sepsis.

Results
circFLNA was upregulated in the intestinal epithelium after abdominal sepsis induced by intestinal perforation. Inhibition of miR-766-3p impaired si-circFLNA-mediated inhibition of apoptosis and inflammation factor levels in lipopolysaccharide (LPS)-treated HIEC-6 cells. circFLNA aggravated apoptosis and inflammation through the Fas-mediated apoptosis pathway in both LPS-treated HIEC-6 cells and a mouse cecal ligation and puncture model.

Conclusion
Our findings showed that circFLNA promotes intestinal injury in abdominal sepsis through the Fas-mediated apoptosis pathway by sponging miR-766-3p. The circFLNA/miR-766-3p/Fas axis has potential as a novel therapeutic target for treating intestinal injury in sepsis.
Low Mach Number Limit for the Degenerate Navier–Stokes Equations in Presence of Strong Stratification
Authors: Fanelli Francesco , Zatorska Ewelina 
Published: January 2023

AbstractIn this paper, we investigate the low Mach and low Froude numbers limit for the compressible Navier–Stokes equations with degenerate, density-dependent, viscosity coefficient, in the strong stratification regime. We consider the case of a general pressure law with singular component close to vacuum, and general ill-prepared initial data. We perform our study in the three-dimensional periodic domain. We rigorously justify the convergence to the generalised anelastic approximation, which is used extensively to model atmospheric flows.
Effects of quinpirole in the ventral tegmental area on impulsive behaviour during performance on the five-choice serial reaction time task
Authors: Toschi Chiara , Robbins Trevor W. , Dalley Jeffrey W. 
Published: January 2023

AbstractImpulsive behaviour on the five-choice serial reaction time task (5CSRTT), a task measuring attention and impulsivity in rodents, is known to depend on dopamine (DA) neurotransmission in the mesolimbic DA pathway. Previous research in our lab reported that systemic administration of the D2/3 agonist quinpirole, which decreases DA release in the striatum, reduced premature responses in rats performing the 5CSRTT. It is unclear, however, whether this effect is mediated by the activation of inhibitory somatodendritic receptors in the ventral tegmental area (VTA), which in turn leads to a reduction in DA release in the nucleus accumbens, a major terminal region of the mesolimbic DA pathway. In the present study, we investigated this possibility by infusing quinpirole directly into the VTA of rats during performance on the 5CSRTT. We found that quinpirole, at the highest dose, significantly reduced the frequency of premature responses on the 5CSRTT. Thus, the effects of quinpirole and other D2/3 receptor agonists to reduce this form of impulsive behaviour appear to depend on the activation of somatodendritic D2/3 receptors in the VTA.
Cabozantinib exposure–response analysis for the phase 3 CheckMate 9ER trial of nivolumab plus cabozantinib versus sunitinib in first-line advanced renal cell carcinoma
Authors: Tran Benjamin Duy , Li Jing , Ly Neang , Faggioni Raffaella , Roskos Lorin 
Published: January 2023

Abstract
Purpose
In the phase 3 CheckMate 9ER trial, intravenous nivolumab (240 mg every 2 weeks) plus oral cabozantinib (40 mg/day) improved progression-free survival (PFS) versus sunitinib as first-line therapy for advanced renal cell carcinoma (RCC). To support cabozantinib dosing with the combination, this exposure–response analysis characterized the relationship of cabozantinib exposure with clinical endpoints.

Methods
Dose modification was allowed with cabozantinib (holds and reductions) to manage adverse events (AEs). The population pharmacokinetics analysis was updated and used to generate individual predicted cabozantinib exposure measures. Kaplan–Meier plots and time-to-event Cox proportional hazard (CPH) exposure–response models characterized the relationship of cabozantinib exposure with PFS, dose modifications, and selected AEs.

Results
Kaplan–Meier plots showed no clear difference in PFS across cabozantinib exposure quartiles. Cabozantinib exposure did not significantly affect the hazard of PFS in the CPH base model nor in the final model. In contrast, baseline albumin and nivolumab clearance had a significant effect on PFS. There was no significant relationship between cabozantinib clearance and risk of dose modification, but a significant relationship was identified between cabozantinib exposure and Grade ≥ 1 palmar-plantar-erythrodysesthesia and Grade ≥ 3 diarrhea in the exposure–response analysis.

Conclusion
To optimize individual cabozantinib exposure, these data support the dose modification strategies in CheckMate 9ER for cabozantinib in patients with advanced RCC when combined with nivolumab.