bluuebunny/crossref_metadata_2025_split huggingface dataset:
Integration of single-cell regulon atlas and multi-omics data for prognostic stratification and personalized treatment prediction in human lung adenocarcinoma
Authors: Xiong Yi , Zhang Yihao , Liu Na , Li Yueshuo , Liu Hongwei , Yang Qi , Chen Yu , Xia Zhizhi , Chen Xin , Wanggou Siyi , Li Xuejun 
Published: May 2023

Abstract
Transcriptional programs are often dysregulated in cancers. A comprehensive investigation of potential regulons is critical to the understanding of tumorigeneses. We first constructed the regulatory networks from single cell RNA sequencing data in human lung adenocarcinoma (LUAD). We introduce LPRI (Lung Cancer Prognostic Regulon Index), a precision oncology framework to identify new biomarkers associated with prognosis by leveraging the single cell regulon atlas and bulk RNA sequencing or microarray datasets. We confirmed that LPRI could be a robust biomarker to guide prognosis stratification across lung adenocarcinoma cohorts. Finally, a multi-omics data analysis to characterize molecular alterations associated with LPRI was performed from The Cancer Genome Atlas (TCGA) dataset. Our study provides a comprehensive chart of regulons in LUAD. Additionally, LPRI will be used to help prognostic prediction and developing personalized treatment for future studies.
Driving Environmental Sustainability and Supply Chain Competitiveness through Green Logistics Management
Authors: LI Tianqi , Pertheban Thillai Raja , Gao Xinxiang 
Published: May 2023

Abstract
The subject of this study is the administration of green supply chain management (GSCM), which refers to a strategy aimed at preventing environmental catastrophes by incorporating eco-friendly practices throughout various processes such as product design, manufacturing, operations, waste management, and more. The implementation of GSCM poses numerous interconnected challenges, as highlighted by research in this field. These challenges were taken into account during the development of the ISM (Interpretive Structural Modeling) model, which aims to address these issues. This model can reduce or eliminate waste levels, leading to improved economic and environmental performance within the industry. Among the identified challenges, two significant hurdles stand out: the need for knowledge about reverse logistics and the requirement for additional workers. These factors contribute to a lack of growth and hinder the industry's ability to reach its full potential. In summary, the study emphasizes the importance of GSCM in combating climate change. It identifies the challenges associated with its implementation, particularly the need for knowledge in reverse logistics and the shortage of workers. Overcoming these challenges is crucial for the industry's advancement and achieving sustainable economic and environmental outcomes.
The Angle of Arrival Estimation of Frequency-Hopping Cooperative Object Based on Software-Defined Radio
Authors: Rustamaji Rustamaji , Kliwati Sri , Widada Wahyu 
Published: May 2023

Abstract
This study aims to investigate and propose a methodology for determining the azimuth angle of cooperative objects with fast processing, more accuracy, and safety. The proposed methodology encompasses the utilization of a transmitter emitting a continuous wave with a hopping frequency, in conjunction with measuring the Angle of Arrival (AOA) between two antennas through the application of interferometry techniques. Furthermore, this study presents an efficient AOA estimation method, which incorporates a sophisticated coarse-to-fine strategy, designed to enhance the processing speed and azimuth angle precision. Additionally, a Fourier bandpass filter is implemented to effectively filter out any signal interference. The Fast Fourier Transform (FFT) algorithm is employed for coarse estimation, whereas the Multiple Signal Classification (MUSIC) algorithms, utilizing coarse angle input and a scan limit of 2.5 degrees, is utilized for fine estimation. The proposed method has been analyzed through modeling and validated through outdoor testing based on Software Defined Radio (SDR), yielding an RMSE of less than 1 degree, utilizing the Blade-RF as the transmitter and the USRP B210 as the receiver.
Effect of Exercise Intervention on Depression in Children and Adolescents: A systematic review and network meta-analysis
Authors: Li Jiayu , Zhou Xianxian , Huang Zan , Shao Tianyi 
Published: May 2023

Abstract
Objectives
To evaluate the effect of different exercise interventions on depressive symptoms in children and adolescents.
Methods
Randomized controlled trials (RCT) published until May 2023 were screened in seven databases. The Cochrane collaboration tool was used to assess the risk of bias for quality evaluation. Stata 16.0 software was used for both a pairwise meta-analysis and a series of frequentist network meta-analyses (NMA).
Results
A total of 35 RCTs and 5393 participants were included. Aerobic exercise had the most significant effect on depressive symptoms (66.2%), followed by game training (62.5%), resistance exercise (59.0%), and aerobic combined with resistance exercise (57.9%). Furthermore, children and adolescents younger than 15 years showed significant improvement in depressive symptoms (SMD=-0.41, 95% CI (-0.63, -0.19), P < 0.01). The study also found a significant improvement in depression among healthy, obese, and depressed populations (SMD=-0.75, 95% CI (-1.32, -0.19), P < 0.01; SMD=-0.15, 95% CI (-0.31, -0.00), P < 0.01; SMD=-0.15, 95% CI (-0.31, -0.00), P < 0.01, respectively). A 12-week, three-times-a-week, 40-50-minute exercise intervention was more effective in children and adolescents younger than 15 years. Additionally, 30 minutes of exercise had a significant effect (SMD=-0.14, 95% CI (-0,81, -0.01), P < 0.01), and 40–50 minutes of exercise had the best effect (SMD=-0.17, 95% CI (-0,33, -0.02), P < 0.01). Lastly, exercise frequency of three times per week was significant in children and adolescents (SMD=-0.42, 95% CI (-0,66, -0.18), P < 0.01).
Conclusion
Exercise significantly improves depressive symptoms in children and adolescents, with aerobic exercise having the most significant effect. A 12-week, three-times-a-week, 40-50-minute exercise intervention was found to be more effective in younger children and adolescents, regardless of their health status.
Soil Erosion Estimationin the Bagmati River Basin of Nepal Using RUSLE Modeling to Assess Priority areas for Conservation
Authors: Gelal Devendra , Timilsina Sachin , Ayer Santosh , Bhatta Kishor Prasad , Manandhar Bikram , Maharjan Menuka 
Published: May 2023

Abstract
Soil erosion is a major issue, resulting in the loss of topsoil and fertility. This study estimates total and average soil loss, analyses the effect of Land Use and Land Cover (LULC) on soil erosion, and prioritizes the soil erosion risk zone in the Bagmati river basin using The Revised Universal Soil Loss Equation (RUSLE) model. Rainfall erosivityfactor (R), Soil erodibility factor, Topographic factor, Cover management factor (C), and Support Practice Factor (P) ranged from 94.25 to 666.11 MJ mm ha− 1 h− 1yr− 1, 0.104 to 0.154, 0 to 24.05, 0 to 0.28, and 0.55 to 1 respectively. The computed annual values of soil loss in the basin ranged from 0 to 201.334 t ha− 1yr− 1in 2010 and 0 to 204.687 t ha− 1yr− 1 in 2016. The average soil loss rate of the basin was 21.5 t ha− 1 yr− 1 in 2016. The average annual soil loss was highest in barren land (10.28 tha− 1) while the minimum was in water bodies (0.69 tha− 1). The maximum erosion potential was found in the agricultural land (204.69 tha− 1). Application of bioengineering techniques can control soil losses in the Bagmati river basin. Overall, the application of modern methods and technology i.e., RUSLE and GIS will be useful for the prediction of potential soil losses from river basins thus, managers and policymakers can implement adequate conservation programs with high erosion risk that will reduce soil loss in the future.
Interfacial self-healing polymer electrolytes for ultralong-life solid-state lithium-sulfur batteries
Authors: Pei Fei , Wu Lin , Zhang Yi , Liao Yaqi , Kang Qi , Han Yan , Zhang Huangwei , Shen Yue , Xu Henghui , Li Zhen , Huang Yunhui 
Published: May 2023

Abstract
Coupling high capacity cathode and Li metal anode with the solid-state electrolyte has been demonstrated as an effective strategy for increasing the energy density and enhancing the safety of rechargeable batteries. However, the limited ion conductivity of the solid-state electrolyte, the large interfacial resistance of electrode/electrolyte, and the unconstrained dendrite growth of the Li metal anode are still the main challenges hindering the applications of the solid-state Li-metal batteries (SSLMB). Herein, a poly(ether-urethane) based solid-state polymer electrolyte (SPE) with self-healing property are designed to reduce the interface impedance and achieve high performance SSLMB. Benefiting from the dynamic covalent disulfide bonds rearrangement and the hydrogen bonds between urethane groups, the proposed SPE exhibits excellent interfacial self-healing ability, which can help to constantly maintain well interfacial contact between solid-state electrolyte and cathode/anode electrodes during the whole cycling life. By casting the designed SPE directly on the sulfur-based cathodes and Li metal anode, it can be easily prepared the integrated solid-state electrolyte/electrode structures, and then assembled them into full cells. As a result, the Li||Li symmetric cells achieved a long-term cycling stability of more than 6000 h, and the solid-state Li-S batteries show prolonged cycle life of 700 times accompanied with excellent C-rate properties. By using ultrasound imaging technology, it is proved that the interfacial contact of the integrated solid-state electrolyte/electrode structure is much better than traditional laminated ones. The application of the proposed interfacial self-healing SPEs and the integrated electrodes could be easily extended to mass production of high-performance solid-state batteries.
The Effect of Social Media on High-School Student’s Behavioral Change: A Case Study of Bikolos Nur Academy, Addis Ababa, Ethiopia, 2022
Authors: Mohammed Fuad Ahmed , Bedewi Zulfa 
Published: May 2023

Abstract
Background: Social media has positive, beneficial consequences for its users. But it also has unfavorable impacts, particularly on the youth population of high school pupils. The aim of the study is to assess the effects of social media on high-school students’ behavioral change at Bikolos Nur Academy, Addis Ababa, Ethiopia, 2022.
Methodology:A Survey (Cross-sectional) study design was conducted. Primary data was collected from a sample size of 104 high school students using a self administered questionnaire. Participants were recruited using simple random sampling method. The data was cleaned, entered and analyzed using SPSS version 26.0 statistical software and MS excel. Descriptive statistics and logistic regression analyses including bivariate and multivariate logistic regression analysis were used for analysis. Level of significance was determined at 95% confidence and p-value<0.05.
Result: All the participants were social media users with Male=46.2% and Female=53.8% of gender distribution. The most commonly used platform were Telegram(67.3%), Instagram(62.5%), Ticktock(56.7%) and YouTube(47.1%). Most students perceived that social media is essential for high-school students but 82.7% of them were using social media for reasons stated other than academic related. Use of social media (p=0.001, Exp(B)=0.507); time spent on social media(p=0.007, Exp(B)=0.094); the reason for social media usage(p=0.014, Exp(B)=0.205); and students perception for social media usages (p=0.021, Exp(0.531) were the significant factors identified.
Conclusion and Recommendations: The major determinants for social media related high-school students behavioral change were use of social media, time spent on social media, the reason for social media usage and students perception for social media usages.Students are recommended to use social media only for rightly intended and academic related purposes.
Ocular Refractive Development of Children and Adolescents in the Potential Postpone/Cease Myopic Shift during Early Emmetropization- A Predictive Model Description
Authors: Yang Chih-Huang , Cui Shi-Rui , Lin Hsien-Chang , He Yue , Duan Jun-Guo , Lih Chong-Chung 
Published: May 2023

Abstract

Purpose︰To assess the potential for delaying or halting myopic excursion during early emmetropization in children and adolescents. Methods：We followed a population in southern Taiwan, of which we analyzed 69 individuals with refractive errors, a total of 137 eyes, initially between recalled the ages of 7 and 18 years, and recorded for up to 10 years with five refractive corrections at least . We also build a mathematical model to fit/analyze all the data and understand the progression of human eye refractive development as well as the myopic refraction shift during early emmetropization. Results︰The model predictive errors for the fifth refraction were 0.44 dioptres, and the sharpest myopic progression was observed between the ages of 10.21 and 15.93. The average annual refraction change of the eyes was -0.61 dioptres. The myopic refraction of females tended to progress faster than those of males, however the refraction stabilized earlier in early adulthood for females, while it continued to see myopic progression in the males. The individuals had myopia onset earlier than 9, between 9 and 11, and older than 11, also showed different negative growth factor in the model. Conclusions︰The concepts of myopia prevention need to be reformed, that is, instead of regarding hyperopia as reserve at early emmetropization, as paying attention at NG and the time point for an appropriate intervention, so a good model is required.
Genome and Clonal Hematopoiesis Stability Contrasts with Immune, cfDNA, mitochondrial, and telomere length changes to Short Duration Spaceflight
Authors: Medina J. Sebastian Garcia , Narayanan S. , Sienkiewicz Karolina , Overbey Eliah , Grigorev Kirill , Ryon Krista , Proszynski Jacqueline , Burke Marissa , Schmidt Caleb , Tierney Braden , Mencia-Trinchant Nuria , Klotz Remi , Ortiz Veronica , Foox Jonathan , Damle Namita , Najjar Deena , Matei Irina , Shakib Lorien , Kim JangKeun Kim , Singaraju Anvita , Taylor Lynn , Schmidt Julian , Schmidt Michael , Blease Kelly , Moreno Juan , Boddicker Andrew , Zhao Junhua , Lajoie Bryan , Altomare Andrew , Kruglyak Semyon , Levy Shawn , Yu Min , Hassane Duane , Bailey Susan , Bolton Kelly , Mateus Jaime , Mason Christopher 
Published: May 2023

Abstract
The I4 mission, the first all-civilian orbital flight mission, investigated the physiological effects of short duration spaceflight through a multi-omic approach. We analyzed telomere length, clonal hematopoiesis of indeterminate potential (CHIP), whole genome stability, cell-free DNA (cfDNA) cell lysis, and immune cell gene expression. Our results revealed telomere length dynamics similar to those observed in the NASA Twins Study and in astronauts spending 6 months on the ISS, with lengthening in space and shortening upon return to Earth. Our cell-type of origin analysis of cfDNA fragments revealed an increased presence of innate and adaptive immune cell signatures that persisted over a month after return to earth. No significant relationship between spaceflight and CHIP-related or whole genome abnormalities were observed. Longitudinal mitochondrial, ribosomal and immune function gene expression changes occurred across both adaptive and innate immune cells, suggesting adaptations to the space environment can extend months after return from spaceflight and alter immune function. Our findings provide valuable insights into the physiological consequences of short duration spaceflight and will serve as a reference point for future space tourism, low Earth-orbit (LEO) missions, and deep-space exploration.
Spontaneous hypoglycemia: Should we mind the gap? Long-term follow-up of healthy people who met Whipple´s Triad
Authors: Adelmeyer Jan , Schauer Christian Marcel , Kann Peter Herbert 
Published: May 2023

Abstract
Context: Patients discharged as “healthy” with the symptom of spontaneous hypoglycemia need more attention.Objective Characterization and long-term follow-up of these patientsMethods Retrospective analysis and questionnaire follow-upSetting: Center for Endocrinology, Diabetology and Osteology at the University Hospital Marburg, Inpatient DepartmentPatients: All patients who presented to our center for the 72-hour fast between 2005 and 2018 and were discharged without an internal medicine diagnosis were included.Interventions: Survey by questionnaireMain outcome measures: Patient-reported information about current symptoms compared to original symptoms, diagnosis of insulinoma or diabetes mellitus during follow-up, matched with primary care physician data, metabolic and biometric data such as body mass index (BMI), homeostasis model assessment for insulin resistance (HOMA IR), insulin sensitivity Matsuda Index (ISI-M) and area under the curveResults A total of 41 data sets were evaluated at baseline and 38 patients were followed for an average of approximately 10 years. 61% of respondents still reported the same symptoms as at baseline. No insulinoma was missed in these patients. Only two of the 38 patients developed diabetes mellitus.Conclusion The high percentage of patients who are discharged as "healthy" and still have symptoms after many years is disturbing. It is possible that the symptoms are not due to low blood glucose. We urge caution with the term "healthy". In addition, more research should be done on this topic.
BMC Infect Dis Journal Staphylococcus epidermidis induced Toxic Shock Syndrome (TSS) following influenza infection
Authors: Armeftis Charis , Ioannou Andreas , Lazarou Theodorakis , Giannopoulos Achilleas , Dimitriadou Efrosyni , Makrides Kostantinos , Pana Zoi Dorothea 
Published: May 2023

Abstract
Background To date, few cases of TSS caused by coagulase negative (CoN) staphylococci have been reported in the literature. Recent data show that CoN staphylococci are capable of secreting a number of enterotoxins and cytotoxins, normally produced by S. aureus. Herewith, we describe a case of TSS caused by Staphylococcus epidermidis with a favorable outcome.
Case presentation We report a case of a 46-year-old man who developed TSS from S. epidermidis. The patient was admitted for a 7-day history of general malaise and headache following a recent influenza infection and a 3-day history of vomiting, diarrhea, diffuse erythroderma, and fever. The main laboratory findings on admission were leukopenia (WBC 800/mm3), thrombocytopenia (Plt count 78.000/mm3), elevated urea, creatine levels and increased inflammatory markers (CRP 368 mg/ml). The patient had clinical and radiological evidence of pneumonia with chest computed tomography (CT) showing diffuse bilateral airspace opacifications with air bronchogram.
On the second day, a methicillin resistant S. epidermidis (MRSE) strain was detected in both sets of blood cultures, but the organism was unavailable for toxin testing. All other cultures and diagnostic PCR tests were negative. His clinical signs and symptoms fulfilled at that stage four out of five clinical criteria of TSS with a fever of 39 °C, diffuse erythroderma, multisystem involvement and hypotension. On the same day the patient was admitted to the ICU due to acute respiratory failure. The initial treatment was meropenem, vancomycin, levofloxacin, clindamycin, IVIG and steroids. Finger desquamation appeared on the 9th day of hospitalization, fulfilling all five clinical criteria for TSS.
Conclusions To our knowledge, this is the first adult case with TSS induced by CoNS (MRSE) following an influenza type B infection, who had favorable progression and outcome. Further research is warranted to determine how TSS is induced by the CoNS infections.
Which behaviour change techniques are associated with interventions that increase physical activity in pre-school children? A systematic review
Authors: Al-walah Mosfer A , Donnelly Michael , Cunningham Conor , Heron Neil 
Published: May 2023

Abstract

BackgroundInsufficient physical activity (PA) is a significant risk factor that contributes to obesity and there is a need to improve understanding about how to increase PA, particularly among young children. This review (PROSPERO registration: CRD42022328841) investigated the relationship between Behaviour Change Techniques (BCTs) and interventions that increased PA among young children (< 6 years old, pre-school).MethodsSystematic searches of six databases were undertaken from inception to July 2022, updated in December 2022, to locate trials that evaluated interventions and reported a positive change in PA levels in children aged < 6 years old.ResultsA total of 5,304 studies were screened and 28 trials involving 10,605 subjects aged from 2.5 to 5.9 years old met eligibility criteria. Each eligible study (n = 28) was independently appraised by two researchers using the Cochrane risk of bias tool. The BCT Taxonomy v1 and the Template for Intervention Description and Replication (TIDieR) guided the extraction and analysis of data and this process led to the identification of 27 BCTs.ConclusionsPotentially promising BCTs for increasing PA among young children included ‘shaping knowledge,’ ‘antecedents,’ ‘goals and planning,’ and ‘comparison of behaviour.’ Future PA interventions that target young children should consider integrating these promising BCTs into their programmes. However, such consideration needs to be tempered with the fact that most reviewed studies were deemed to have a high or unclear risk of bias and/or were limited with respect to the populations they targeted. There is a need for further methodologically rigorous intervention research that prioritises at-risk child populations with low PA levels, particularly children from disadvantaged socioeconomic communities.
Indoor Aeromycological Studies in Primary Health Centers In Amravati District Maharashtra , India
Authors: Vaidya Rasika Dipakrao , Shahare N.H. 
Published: May 2023

Abstract
An aeromycological studies verifies the presence of air born fungi. It is very important to study fungal propagules in hospitals and health centres in context to Covid-19 pandemics. In the present research attempts were made to determine aeromycoflora of indoor environment of two Primary Health Centers (PHC1 and PHC2) in rural places of Amravati District in Maharashtra state in India. The samples were collected in the month of December 2022 and February 2023. The petriplate exposure method was used for the isolation of fungal mycoflora . In December 2022 Cladosporium cladosporioide and Aspergillus niger shows the highest percent contribution while Mucor hiemalis Fusarium sp and ,Curvularia lunata shows moderate percent of contribution in indoor environment of both PHCs .In month of February2023 Cladosporium cladosporioide shows dominance in both the PHCs and Aspergillus niger, Mucor hiemalis and Alternaria alternata were reported in moderate concentration. Some of these fungal species were reported as human pathogens.