bluuebunny/crossref_metadata_2025_split huggingface dataset:
Endometriosis and risk of depression among oral contraceptive users: a pooled analysis of cohort studies from 13 countries
Authors: De Corte P , Milhoranca I , Oberg A S , Kurth T , Mechsner S , Heinemann K 
Published: January 2025

Abstract

STUDY QUESTION
Does endometriosis affect the mental health of women using oral contraceptives?

SUMMARY ANSWER
Among oral contraceptive users, women with endometriosis have a higher risk of depression compared to those without endometriosis, although the absolute risk increase is small.

WHAT IS KNOWN ALREADY
Previous studies have suggested a potential link between endometriosis and mental health issues, but the impact of endometriosis on depression among oral contraceptive users remains unclear.

STUDY DESIGN, SIZE, DURATION
A secondary pooled cohort study utilizing data from two longitudinal patient-centric studies (INAS-VIPOS and PRO-E2) was conducted across 11 European countries, Colombia and Australia. The study included 93 541 women newly prescribed oral contraceptives, with or without endometriosis, and without a self-reported history of depression.

PARTICIPANTS/MATERIALS, SETTING, METHODS
Participant’s mental health was captured using self-administered questionnaires at baseline and every 6–12 months thereafter, asking about any newly occurred episodes of depression. Incidence rates (IRs) of self-reported depression were calculated per 10 000 woman-years. Absolute risk difference (ARD) and number needed to harm (NNH) were calculated with 95% CIs. The association between endometriosis and self-reported depression was estimated through crude and adjusted hazard ratios (HRs) with 95% CI, using stabilized inverse probability of treatment weighting (IPTW).

MAIN RESULTS AND THE ROLE OF CHANCE
Of the included 93 541 women, 21 090 had endometriosis (49 541 woman-years) and 72 451 had no endometriosis (137 137 woman-years.) Of those with endometriosis, 308 (1.5%) reported an episode of depression (IR: 62.2/10 000, 95% CI: 55.4–69.5) compared to 535 (0.7%) of women without endometriosis (IR 39.0/10 000, 95% CI: 35.8–42.5). The ARD and NNH were 23.2 per 10 000 (95% CI: 15.2–30.9) and 431 (95% CI: 323.7–657.0) respectively. The HR of depression in women with endometriosis was 1.85 (95% CI: 1.60–2.13) using stabilized IPTW to control for age, BMI, smoking, education, and age at menarche. Subgroup and sensitivity analyses showed similar results.

LIMITATIONS, REASONS FOR CAUTION
While efforts were made to control for confounding factors, residual confounding may still exist. Additionally, the results can only be generalized to users of oral contraceptives.

WIDER IMPLICATIONS OF THE FINDINGS
These results highlight the importance of considering the mental health implications of endometriosis among women using oral contraceptives. Further research is needed to explore additional contributing factors and potential interventions.

STUDY FUNDING/COMPETING INTEREST(S)
No funding was received for this study. No competing interests apply for this research.

TRIAL REGISTRATION NUMBER
N/A.
Impact of microwave processing and high pressure processing on omega-3 fatty acid enriched snack of microalgae (Nannochloropsis sp)-cocoa balls
Authors: Luo Tong , Ninan Neethu , Truong Vi Khanh , He Shan , Alhaji Jwaher Haji , Binobead Manal Abdulaziz 
Published: January 2025

Abstract
This study investigates the development of a functional snack, NSP (Nannochloropsis sp.)-cocoa balls, enriched with omega-3 fatty acids, utilizing two advanced processing methods: microwave processing and high-pressure processing (HPP). The primary objective was to assess the efficiency of these techniques in preserving nutritional value, particularly omega-3 content, while maintaining desirable sensory qualities over a 12-day storage period. Microwave processing was found to partially retain omega-3 fatty acids but resulted in increased firmness and faster oxidation due to moisture loss during heating. In contrast, HPP effectively preserved omega-3 content and maintained the original texture and sensory appeal of the NSP-cocoa balls. The even distribution of omega-3 fatty acids in HPP-treated samples enhanced their resistance to oxidation, contributing to greater stability. Sensory evaluations identified the HPP-treated cocoa balls, specifically those prepared using Recipe 4, as the most preferred for their texture and superior nutritional profile. Furthermore, food safety analyses confirmed the safety of these snacks for consumption throughout the storage period. This comprehensive study highlights HPP as a superior processing method for developing functional foods that balance nutrient preservation with sensory quality, offering a promising approach for creating health-focused, shelf-stable snacks.
Preclinical evaluation of the efficacy and safety of adeno-associated virus 8-tissue-nonspecific alkaline phosphatase-D10 in Alpl-/- and AlplPrx1/Prx1 mouse models for the treatment of early and late-onset hypophosphatasia
Authors: de Oliveira Flavia Amadeu , Tokuhara Cintia Kazuko , Mohamed Fatma F , Narisawa Sonoko , Lira dos Santos Elis J , Andras Natalie L , Shadid Mohammad , Miyake Koichi , Foster Brian L , Millán José Luis 
Published: January 2025

Abstract
We previously documented successful resolution of skeletal and dental disease in the infantile and late-onset murine models of hypophosphatasia (HPP) with a single injection of an adeno-associated serotype 8 vector encoding mineral-targeted TNAP (AAV8-TNAP-D10). Here, we conducted dosing studies in both HPP mouse models. A single escalating dose from 4 × 108 up to 4 × 1010 (vg/b) was intramuscularly injected into 4-day-old Alpl-/- mice (an infantile HPP model) and a single dose from 4 × 106 up to 4 × 109 (vg/b) was administered to 8-wk-old AlplPrx1/Prx1 mice (a late-onset HPP model). Wild-type littermates were used as controls. Serum alkaline phosphatase activity was increased, and PPi levels were decreased in a dose-dependent manner in both the Alpl-/- and AlplPrx1/Prx1 models. Radiographic and μCT analysis of long bones of female and male Alpl-/- mice showed full correction of skeletal phenotype at 4 × 1010 vg/b. We observed full correction of the bone phenotype at 4 × 108 and 4 × 109 in female AlplPrx1/Prx1 mice, but bones remained hypomineralized with the 4 × 106 and 4 × 107 (vg/b) doses after 70 d of treatment. We observed skeletal improvements using the 4 × 109 (vg/b) dose, but the phenotype was not fully corrected in male AlplPrx1/Prx1. Immunohistochemistry using anti-TNAP and anti-D10 antibodies showed high immunolocalization in the femurs of female AlplPrx1/Prx1 mice, while D10 immunolocalization was high in the liver of male AlplPrx1/Prx1 mice at a dose of 4 × 109 (vg/b). This sex-dependent difference was not seen in the infantile HPP model. A serum proteome analysis showed enhanced inflammatory pathways in treated AlplPrx1/Prx1 males compared to treated female mice. We also found a few areas of ectopic calcification in soft organs at the highest tested dose of 4 × 1010 (vg/b) in Alpl-/- or 4 × 109 (vg/b) in the AlplPrx1/Prx1 model. This pre-clinical study will inform the design of clinical trials to develop gene therapy in early-onset and late-onset HPP patients.
Functional performance and symptomatology of adults with skeletal dysplasia across self-care, mobility, and cognition—a cross-sectional study
Authors: Nguyen Daphne , Ireland Penelope , Pacey Verity 
Published: January 2025

Abstract
Individuals with skeletal dysplasia (SD) experience physical challenges in performing everyday activities as a result of their altered biomechanics and systemic comorbidities. The purpose of this study was to objectively assess functional performance and identify symptomatology across self-care, mobility, and cognitive tasks among adults with SD. The secondary aim was to describe any differences in performance between individuals with proportionate forms of SD compared with those with disproportionate forms. A cross-sectional online survey and functional assessment, the Functional Independence Measure (FIM), was administered to adults diagnosed with SD. Summary statistics were computed and analyzed. Survey open-ended text responses were examined. Data were collected on 40 adults (median age 41.2 yr) presenting with 10 types of SD (14 with proportionate SD, 26 disproportionate SD). A total of 39 (97.5%) participants required assistance or modification when completing functional activities. Increased reliance on assistance was observed across self-care and mobility tasks (median FIM scores 51/56 and 31.5/35 respectively), compared with cognitive items (median FIM score 34.5/35). Up to 50% of participants reported experiencing pain, fatigue, and/or other symptoms during self-care and mobility tasks. These symptoms were more prevalent when completing self-care activities at home and when mobilizing in the community. Participants with proportionate forms of SD demonstrated higher levels of independence in upper body dressing, toileting, and bed/chair/wheelchair transfers, whereas participants with disproportionate forms had higher scores in eating and grooming tasks. Adults with SD demonstrated functional challenges and symptomatology associated with activities of daily living. Overall, there are minimal differences in FIM scores between individuals with proportionate forms of SD and those with disproportionate forms. Use of assistive equipment, modifications, and allowing extra time with tasks may improve independence among this population group.
Chemical compounds associated with Schistocerca piceifrons piceifrons (Orthoptera: Acrididae), by Gas Chromatography–Mass Spectrometry analysis
Authors: García-García Luis Daniel , Barrientos-Lozano Ludivina , Torres-Castillo Jorge Ariel , Rocha-Sánchez Aurora Y , Almaguer-Sierra Pedro , González-Gaona Othón Javier , Rodríguez-Rodríguez José 
Published: January 2025

Abstract
Semiochemicals are chemicals that mediate inter- and intraspecific interactions between insects. Recently, these chemicals have begun to be investigated as an alternative for the management of the Central American locust, Schistocerca piceifrons piceifrons (Walker, 1870), a pest that can cause substantial damage to crops, pastures, and native vegetation. A suitable method for investigating the range of semiochemicals present in Central American locust is surface washing in organic solvents. In the work described here, the extraction of chemical compounds was carried out with hexane in a 1:10 (w/v) ratio, in 2 resting periods (1 and 24 h) and 2 stages of Central American locust development (young adult and adult in reproductive stage). By Gas Chromatography–Mass Spectrometry, 17 chemical compounds previously identified with semiochemical potential in other insects were detected. The study of semiochemicals in Central American locust offers the opportunity to identify specific chemical compounds that may have the potential to implement management alternatives for this pest. Specific studies of each compound detected in this work are needed to elucidate whether they have semiochemical activity and potential to combat the pest and reduce the environmental damage caused by the application of synthetic chemical products.
Making the case for an International Childhood Cancer Data Partnership
Authors: Forjaz Gonçalo , Kohler Betsy , Coleman Michel P , Steliarova-Foucher Eva , Negoita Serban , Guidry Auvil Jaime M , Michels Fernanda Silva , Goderre Johanna , Wiggins Charles , Durbin Eric B , Geleijnse Gijs , Henrion Marie-Charlotte , Altmayer Candice , Dubois Thomas , Penberthy Lynne 
Published: January 2025

Abstract
Childhood cancers are a heterogeneous group of rare diseases, accounting for less than 2% of all cancers diagnosed worldwide. Most countries, therefore, do not have enough cases to provide robust information on epidemiology, treatment, and late effects, especially for rarer types of cancer. Thus, only through a concerted effort to share data internationally will we be able to answer research questions that could not otherwise be answered. With this goal in mind, the US National Cancer Institute and the French National Cancer Institute co-sponsored the Paris Conference for an International Childhood Cancer Data Partnership in November 2023. This meeting convened more than 200 participants from 17 countries to address complex challenges in pediatric cancer research and data sharing. This Commentary delves into some key topics discussed during the Paris Conference and describes pilots that will help move this international effort forward. Main topics presented include: (1) the wide variation in interpreting the European Union’s General Data Protection Regulation among Member States; (2) obstacles with transferring personal health data outside of the European Union; (3) standardization and harmonization, including common data models; and (4) novel approaches to data sharing such as federated querying and federated learning. We finally provide a brief description of 3 ongoing pilot projects. The International Childhood Cancer Data Partnership is the first step in developing a process to better support pediatric cancer research internationally through combining data from multiple countries.
Sex differences in melanoma survival—a GEM study
Authors: Murali Tharani , Schwartz Matthew , Reynolds Adam Z , Luo Li , Ridgeway Grace , Busam Klaus J , Cust Anne E , Anton-Culver Hoda , Gallagher Richard P , Zanetti Roberto , Rosso Stefano , Sacchetto Lidia , Begg Colin B , Orlow Irene , Thomas Nancy E , Berwick Marianne ,   for the GEM Study Team, Berwick Marianne , Begg Colin , Orlow Irene , Busam Klaus J , Berwick Marianne , Luo Li , Boyce Tawny W , Cust Anne E , Armstrong Bruce K , Kricker Anne , Venn Alison , Dwyer Terence , Tucker Paul , Gallagher Richard P , Marrett Loraine D , Zanetti Roberto , Rosso Stefano , Sacchetto Lidia , Anton-Culver Hoda , Gruber Stephen B , Huang Shu-Chen , Thomas Nancy E , Conway Kathleen , Ollila David W , Googe Paul B , Edmiston Sharon N , Hao Honglin , Parrish Eloise , Gibbs David C , Rebbeck Timothy R , Kanetsky Peter A , Taylor Julia Lee , Madronich Sasha , Roy Pampa , Canchola Rebecca , LaPilla Emily , Yoo Sarah , Sharma Ajay , Cotignola Javier , Eaton Alison , Groben Pamela , White Kirsten , Walker Amy , Panossian Saarene 
Published: January 2025

Abstract
Sex differences in melanoma are prominent, with female having a significant survival advantage. However, it is unclear why we see this survival advantage. Here, we investigate the relationship between sex, clinicopathologic variables, and melanoma specific survival in 1753 single primary melanomas from patients in the GEM (Genes, Environment, and Melanoma) study. Using Cox proportional hazard models and formal mediation analysis, the effect of sex on survival is explained largely by differences in the clinicopathologic features of tumors at diagnosis. Specifically, we find evidence that 86.5% of the effect of sex on melanoma survival is mediated by differences in age at diagnosis, Breslow thickness, ulceration, mitoses, and site (hazard ratio [HR] = 1.85, P &lt; .001). This analysis indicates that the female survival advantage in melanoma is not primarily due to a direct effect of sex (HR = 1.19, P = .42) but is largely a result of an indirect effect of sex mediated by clinicopathologic features.
Overcoming prejudices and stigmatization towards refugees: A novel approach through deliberative citizen dialogues in Turkey
Authors: Yabanci Bilge 
Published: January 2025

Abstract
Can changing how refugees and asylum seekers are narrated in public debates help citizens reassess their prejudices? Which narratives would garner support from ordinary citizens and promise to generate an attitude shift? While hate speech and far-right narratives targeting forcibly displaced people, refugees and asylum seekers are reported extensively, little is known about how citizens would respond to alternative narratives that portray them as rights-bearing agents. This study uses an interdisciplinary theoretical framework that brings migration scholarship in dialogue with cognitive fields and social psychology and offers a novel participatory approach to generate data. In eight cities across Turkey, citizens were invited to deliberate three sets of ‘de-stigmatizing narratives’ based on (1) social solidarity, (2) collective memory of welcoming and settling refugees in the past, and (3) the injustices of exploitation that refugees encounter while earning a living. Participants were steered to discuss each narrative through (a) progressive framing (fairness, egalitarianism, and social cohesion) and (b) conservative-nationalist framing (maintenance of law, order, and identity). The findings reveal that engaging with de-stigmatizing narratives evokes affective empathy, leading to moderate, refugee-supportive attitudes among participants even in a context where anti-refugee attitudes have escalated to communal attacks targeting refugees. However, positive attitudes towards refugees display a local turn, varying by city and often after progressive frames are supported by conservative-nationalist ones. The study highlights the importance of participatory community mobilization and sub-national/local approaches to shift, counter, or replace prevailing narratives to help reduce misinformation and prejudices about refugees.
Revisiting the cosmological time dilation of distant quasars: influence of source properties and evolution
Authors: Brewer Brendon J , Lewis Geraint F , Li Yuan (Cher) 
Published: January 2025

ABSTRACT
After decades of searching, cosmological time dilation was recently identified in the time-scale of variability seen in distant quasars. Here, we expand on the previous analysis to disentangle this cosmological signal from the influence of the properties of the source population, specifically the quasar bolometric luminosity and the rest-frame emission wavelength at which the variability was observed. Furthermore, we consider the potential influence of the evolution of the quasar population over cosmic time. We find that a significant intrinsic scatter of $0.288 \pm 0.021$ dex in the variability time-scales, which was not considered in the previous analysis, is favoured by the data. This slightly increases the uncertainty in the results. However, the expected cosmological dependence of the variability time-scales is confirmed to be robust to changes in the underlying assumptions. We find that the variability time-scales increase smoothly with both wavelength and bolometric luminosity, and that black hole mass has no effect on the variability time-scale once rest wavelength and bolometric luminosity are accounted for. Moreover, if the standard cosmological model is correct, governed by relativistic expansion, we also find very little cosmological evolution in the intrinsic variability time-scales of distant quasars.
Searching for short-timescale radio anomalies using nonlinear dimensionality reduction techniques
Authors: Yang X , Hobbs G , Zhang S-B , Zic A , Toomey L , Li Y , Wang J-S , Dai S , Wu X-F 
Published: January 2025

Abstract
We have searched for anomalous events using 2,520 hours of archival observations from Murriyang, CSIRO’s Parkes radio telescope. These observations were originally undertaken to search for pulsars. We used a machine-learning algorithm based on ResNet and Uniform Manifold Approximation and Projection (UMAP) in order to identify parts of the data stream that potentially contain anomalous signals. Many of these anomalous events are radio frequency interference, which were subsequently filtered using multibeam information. We detected 202 anomalous events and provide their positions and event times. Our results show that the UMAP unsupervised machine learning pipeline effectively identifies anomalous signals in high-time-resolution datasets, highlighting its potential for use in future surveys. However, the pipeline is not applicable for standard searches for dispersed single pulses. We classify the detected events and, in particular, we are currently unable to determine the possible origin of events that last multiple seconds. For these we encourage follow-up observations.
Investigation of oscillations above the acoustic cut-off frequency for a sample of Kepler stars. II. Identifying temporal frequency shifts
Authors: Millson L J , Broomhall A-M , Santos A R G , Kiefer R , Jones M 
Published: January 2025

ABSTRACT
Stellar oscillations with frequencies greater than the acoustic cut-off frequency are not trapped within the star’s interior. Geometric interference between these high-frequency waves produces a peak-like structure in the power spectrum of the star, known as the pseudo-modes. In this study, we aim to analyse 51 stars previously identified (from a sample of 91 Kepler stars) to contain statistically significant evidence for pseudo-modes, to determine if the pseudo-mode frequencies vary in time. We obtained these frequency variations and the uncertainty by the resampled periodogram approach, where periodogram realisations were created from successive, overlapping 90-d time segments, and a cross-correlation function was generated between them. The computed shifts were compared against temporal p-mode frequency shifts and a stellar magnetic activity proxy, $S_{\mathrm{ph}}$. We found that for 16 per cent of the stars pseudo-mode frequency shifts were significantly anticorrelated with p-mode shifts, as is the case for the Sun. However, we also found pseudo-mode and p-mode shifts to be significantly correlated in-phase in 8 per cent of our sample. The remainder showed no significant correlation. We also searched for trends between the maximum variation of pseudo-mode frequency shifts and stellar parameters. Whilst we found no correlation between the maximum variation and stellar photospheric and chromospheric proxies, we found frequency variations to have a greater amplitude for cooler and slower rotating stars, which is in opposition to p-mode frequency shift variation. Temporal changes to pseudo-mode frequencies may be attributable to variations in stellar magnetic activity, and therefore can contribute to our understanding of stellar activity cycles.
Resonant capture of stars by black hole binaries: extreme eccentricity excitation
Authors: Reved Omri , Friedland Lazar , Stone Nicholas C 
Published: January 2025

ABSTRACT
Massive black hole (MBH) binaries in galactic nuclei are one of the leading sources of ${\sim}$mHz gravitational waves (GWs) for future missions such as Laser Interferometer Space Antenna (LISA). However, the poor sky localization of GW interferometers will make it challenging to identify the host galaxy of MBH mergers absent an electromagnetic counterpart. One such counterpart is the tidal disruption of a star that has been captured into mean motion resonance with the inspiralling binary. Here we investigate the production of tidal disruption events (TDEs) through capture into, and subsequent evolution in, orbital resonance. We examine the full non-linear evolution of planar autoresonance for stars that lock into autoresonance with a shrinking MBH binary. Capture into the 2:1 resonance is guaranteed for any realistic astrophysical parameters (given a relatively small MBH binary mass ratio), and the captured star eventually attains an eccentricity $e\approx 1$, leading to a TDE. Stellar discs can be produced around MBHs following an active galactic nucleus episode, and we estimate the TDE rates from resonant capture produced when a secondary MBH begins inspiralling through such a disc. In some cases, the last resonant TDE can occur within a decade of the eventual LISA signal, helping to localize the GW event.