bluuebunny/crossref_metadata_2025_split huggingface dataset:
Earlier menopause is associated with both reduced cognitive performance and gray matter volume: a population-based cross-sectional study
Authors: Schwarz Nitsan , Harlev Daniel , Bergmann Eyal , Wolpe Noham 
Published: February 2025

AbstractBackgroundAge at menopause varies widely across women, yet little is known about how this relates to long-term behavioral and brain-structural changes. Previous research has focused primarily on the menopausal transition itself, and the few studies investigating cognitive outcomes suggest reduced age-related cognitive performance with earlier menopause.ObjectivesThis study aims to investigate whether earlier menopause onset is associated with reduced cognitive performance and brain structure in later-life, in the same cohort of postmenopausal women.MethodsWe analyzed data from the Cambridge Centre of Neuroscience and Aging, which included 747 postmenopausal women who underwent cognitive testing (Addenbrooke’s Cognitive Examination Revised, ACE-R). A subset (n=188) was additionally tested with a fluid intelligence test and underwent structural brain scans to measure gray and white matter volume (GMV and WMV). Multiple linear regression models were used to evaluate the association between menopause age and cognitive performance, as well as grey matter volume, controlling for chronological age.ResultsEarlier menopause onset was associated with lower cognitive performance, as measured by the ACE-R (t(719)=2.81,p=0.005). Similar results were found for fluid intelligence (t(146) = 3.116,p=0.002). Structural brain analyses showed that a reduction of one year at the age of menopause onset was associated with a reduction of 2370mm3in total grey matter volume (t(182)=3.37,p=0.001). No significant interactions were observed between menopause onset age and chronological age for any of the outcomes. GMV was a partial mediator between age at menopause onset and cognitive performance, while controlling for age.ConclusionWomen with earlier menopause show both reduced cognitive performance and lower GMV, suggesting that GMV reduction may be one mechanism linking earlier menopause to cognitive decline. However, the cross-sectional nature of this study prevents causal conclusions, and longitudinal research is needed to establish causal links and to explore potential targeted interventions.
Machine Learning Prediction of Non-Coding Variant Impact in Cell-Class-Specific Human RetinalCis-Regulatory Elements
Authors: VandenBosch Leah S. , Cherry Timothy J. 
Published: February 2025

AbstractNon-coding variants in cis-regulatory elements such as promoters and enhancers contribute to inherited retinal diseases (IRDs), however, characterizing the functional impact of most regulatory variants remains challenging. To improve identification of variants of interest, we implemented machine learning using a gapped k-mer support vector machine approach trained on single nucleus ATAC-seq data from specific cell classes of the adult and developing human retina. We developed 18 distinct ML models to predict the impact of non-coding variants on 39,437 cell-class-specific regulatory elements. These models demonstrate accuracy over 90% and a high degree of cell class specificity. Variant Impact Prediction (VIP) scores highlight specific sequences within candidate CREs, including putative transcription factor (TF) binding motifs, that are predicted to alter CRE function if mutated. Correlations to massively parallel reporter assays support the predictive value of VIP scores to model single nucleotide variants and indels in a cell-class-specific manner. These analyses demonstrate the capacity for single nucleus epigenomic data to predict the impact of non-coding sequence variants and allow for rapid prioritization of patient variants for further functional analysis.
Exploring Pain Researcher and Clinician Perceptions of Complementary, Alternative, and Integrative Medicine: A Large-Scale, International Cross-Sectional Survey
Authors: Ng Jeremy Y. , Anheyer Dennis , Cramer Holger 
Published: February 2025

AbstractBackgroundComplementary, alternative, and integrative medicine (CAIM) is gaining popularity among patients experiencing pain, alongside traditional treatments. This study aimed to explore the views of pain clinicians and researchers on CAIM interventions.MethodsAn anonymous, online survey was distributed to 46 223 authors who had published pain-related research in MEDLINE-indexed journals. The survey included multiple-choice questions and open-ended sections to gather detailed opinions.ResultsA total of 1024 participants responded, most identifying as either pain researchers (43.59%) or both researchers and clinicians (39.88%). Many held senior positions (61.55%). Among the CAIM modalities, mind-body therapies such as meditation, yoga, and biofeedback were viewed as the most promising for pain prevention, treatment, and management, with 68.47% of participants endorsing these approaches. While a majority (43.89%) believed that most CAIM therapies are safe, only 25.55% expressed confidence in their effectiveness. There was broad agreement on the need for more research into CAIM therapies, with 45.88% agreeing and 42.53% strongly agreeing that further investigation is valuable.Additionally, many respondents supported the inclusion of CAIM training in clinician education, either through formal programs (46.40%) or supplementary courses (52.71%). Mind-body therapies received the most positive feedback, while biofield therapies were met with the most skepticism.ConclusionThese findings highlight the interest in CAIM among pain specialists and emphasize the need for more research and education tailored to this area.
Spotting the Silent Threat: Early Detection of Subclinical Tuberculosis in High-Risk Individuals
Authors: Daniel Evangeline Ann , Nesakumar Manohar , Hemalatha S , Hilda Nancy , Thiruvengadam Kannan , Vetrivel Umashankar , Selvaraj Anbalagan , Pattabiraman Sathyamurthi , Bhanu Brindha , Sivaprakasam Amsaveni , Natarajan Sudhakar , Kulkarni Vandana , Karyakarte Rajesh , Paradkar Mandar , Bala Yogendra Shivakumar Shri Vijay , Mave Vidya , Chandrasekaran Padmapriyadarsini , Gupta Amita , Hanna Luke Elizabeth 
Published: February 2025

AbstractThe dynamic spectrum of TB often results in underdiagnosis warranting the need for better diagnostics to accurately detectMtbin diagnostically challenging cohorts. Household contacts of newly diagnosed TB patients who developed TB (Progressors) and those who remained healthy (Non-progressors) during a two-year follow-up cohort study were included.MtbccfDNA was detected in the plasma by targeting insertion sequences IS6110 and IS1081 using ddPCR. The assay yielded a sensitivity of 90·9% in detecting subclinical TB cases and 81·8% in possible TB cases. Further, the test detectedMtbccfDNA in progressors even at six months prior to TB diagnosis at a sensitivity of 79·0%. In about 55·0% and 50·0% of casesMtbccfDNA could be detected as early as 12 months and 18 months prior to development of active disease, respectively. The test demonstrated excellent sensitivity (100·0%) in detecting extra-pulmonary TB cases up to six months prior to TB disease development.
Signal partitioning in superfluid
He4
: A Monte Carlo approach
Authors: Toschi Francesco , Brunold Axel , Burmeister Lea , Eitel Klaus , Enss Christian , Fascione Eleanor , Ferber Torben , Gabriel Rahel , Hauswald Lena , Kahlhoefer Felix , Kempf Sebastian , Klute Markus , von Krosigk Belina , Lindemann Sebastian , Maier Benedikt , Schumann Marc , Solmaz Melih , Valerius Kathrin , Wagner Friedrich Carl ,   DELight Collaboration
Published: February 2025

Superfluid He4 is an ideal candidate for the direct detection of light dark matter via nuclear recoils thanks to its low nuclear mass and the possibility to reach a low-detection-energy threshold by exploiting the generated quasiparticles. The design of future detectors based on this target, such as the DELight experiment, requires a proper understanding of the formation and partitioning of the signal for different energy depositions from various sources. This work presents an overview of the physical processes involved in the energy deposition of recoiling electrons and ions, and it describes a Monte Carlo approach to the partitioning of the signal into different channels. Despite an overall good agreement with existing literature, differences in the region of interest for light dark matter searches below 200 eV are observed.

Published by the American Physical Society
2025
Bottomoniumlike states in proton collisions: Fragmentation and resummation
Authors: Celiberto Francesco Giovanni , Gatto Gabriele 
Published: February 2025

We study the semi-inclusive hadroproduction of doubly bottomed tetraquarks (Xbb¯qq¯) as well as fully bottomed ones (T4b), to which we collectively refer as “bottomoniumlike” states. We rely upon the variable-flavor number-scheme fragmentation at leading power, where a single parton perturbatively splits into the corresponding Fock state, which then hadronizes into the color-neutral, observed tetraquark. To this end, we build new sets of /-evo consistent, hadron-structure oriented collinear fragmentation functions, which we name and parametrizations. They extend and supersede the corresponding versions recently derived in previous works. The first family describes the fragmentation of doubly heavy tetraquarks and is based on an improved version of the Suzuki model for the heavy-quark channel. The second family depicts the fragmentation of fully heavy tetraquarks and embodies initial-scale inputs for gluon and heavy-quark channels, both of them calculated by the hands of potential nonrelativistic QCD. As a phenomenological application, we provide novel predictions for tetraquark-plus-jet high-energy distributions, computed within the NLL/NLO+ hybrid factorization from (sym), at 14 and 100 TeV FCC.

Published by the American Physical Society
2025
Integrating lean and resilience: a healthcare supply chain perspective
Authors: Alemsan Najla , Tortorella Guilherme , Portioli Staudacher Alberto , Antony Jiju , Trianni Andrea , Hui Felix 
Published: February 2025

PurposeThis research aims to analyze the deployment of lean practices and resilience capabilities within the healthcare supply chain across different disruptive scenarios. The study addresses the gap in how different tier levels of the healthcare supply chain integrate lean and resilience.Design/methodology/approachEmploying a case study approach, the research evaluated four Italian organizations (two healthcare providers, one pharmaceutical distributor and one pharmaceutical producer) representing the three main tier levels of the healthcare supply chain. The methodology involved a questionnaire assessing the adoption of specific lean practices and resilience capabilities, followed by a scenario analysis by experts used to identify critical practices and capabilities across different disruptive scenarios.FindingsThis research systematically identified critical lean practices and resilience capabilities that are underutilized at various tier levels within the healthcare supply chain, highlighting significant opportunities for theoretical advancement in operational efficiency and system robustness during disruptions. Additionally, the study introduced a novel methodological approach to evaluate the effectiveness of lean and resilience practices across different disruptive scenarios, thereby enriching the theoretical framework for crisis management within healthcare operations. Finally, we emphasized the crucial roles of just-in-time and anticipation capability in bolstering the performance of all the healthcare supply chain.Originality/valueThe study contributes to the fields of supply chain management and healthcare by systematically identifying and classifying the importance of lean practices and resilience capabilities in managing disruptions. Additionally, the potential for cross-tier collaboration and knowledge sharing to enhance overall supply chain resilience is highlighted.
Evaluating blockchain’s impact on financial reporting: opportunities and threats in fintech’s input, processing, and output phases
Authors: Pourrabbi Mir Vahid , Salehi Mahdi , Dalwai Tamanna , Moradi Mahdi 
Published: February 2025

Purpose
The current study aims to investigate the effects of opportunities and threats of using blockchain on the input, processing and output components of the financial reporting process within the fintech landscape.

Design/methodology/approach
This study administered a questionnaire in Iran to 121 university lecturers in accounting and auditing, independent auditors, financial managers and internal auditors to better understand the effect of blockchain on financial reporting. The responses were analysed using SPSS and Smart PLS Software.

Findings
This study demonstrates how blockchain technology can improve the financial reporting process in the fintech industry by providing opportunities for remote labour, improved accountant roles and task automation. Threats include the requirements for blockchain expertise, standardisation, security issues and decreased flexibility. Limited R&D resources pose problems for small businesses. The main advantages of outputs are continuous, timely financial reporting and comparability; the risks associated with customised reports and regulatory difficulties in managing non-financial and financial data are the main disadvantages. The results show that all indicators of opportunities to use blockchain positively and significantly affect financial reporting opportunities within the fintech context. In addition, all the indicators of the threats of using blockchain have a positive and significant effect on the threats of financial reporting in the fintech context.

Originality/value
The present study is designed to meet the needs of a blockchain-based financial reporting system in the fintech context. Rapid growth and transformation into an advanced digital system has increased the importance of understanding the effects of the opportunities and threats of applying blockchain technology.
Evaluation of an online postal take‐home naloxone service
Authors: Harrod Mary Ellen , Sunjic Sandra , Pepolim Lucy , Aylmer Rochelle , Skelley Nicole , Lintzeris Nicholas 
Published: February 2025

AbstractIntroductionNew South Wales User AIDS Association established a pilot postal take‐home naloxone (THN) service to enhance access to THN for people unable or unwilling to attend existing services providing THN (e.g., community pharmacies, needle syringe programs). The service included online registration, educational video and assessment of consumer knowledge regarding THN.MethodsThe evaluation examined the first 10 months of operation (May 2022 to March 2023) and examined service utilisation, the characteristics, motivations and experiences of consumers using the service. The evaluation included service utilisation data, structured online questionnaire and semi‐structured telephone interviews.ResultsTwo hundred forty‐five individuals registered on the online platform, 222 commenced the course, 170 completed viewing the online educational video and commenced the knowledge assessment, and 95 completed the course and ordered 194 THN packs (59% intranasal, 41% intramuscular). Forty‐eight percent of service users were women, and 37% were from regional or rural locations. Key motivations for using the postal service included greater accessibility and convenience (especially for regional and rural participants), greater confidentiality and reduced stigma. There were high levels of satisfaction with the service from consumers, and high levels of confidence that they could respond to a suspected overdose.Discussion and ConclusionThe postal service enhanced access to THN, addressing many of the barriers of existing face‐to‐face services, including geography, convenience, stigma and confidentiality. The postal THN service meets the needs of particular groups of consumers who may otherwise not have accessed THN, and forms an important piece of the puzzle for THN distribution in the community.
Research on the Damage Constitutive Model and Fracture Behavior of Rocks Subjected to Uniaxial and Triaxial Compression
Authors: Shi Sheng , Zhang Yu , Zhang Hui , Zhu Fengjin 
Published: February 2025

ABSTRACTUnder long‐term geological processes, a large number of randomly distributed micro cracks formed within rocks. Due to external loads or disturbances from engineering excavation, the initiation, propagation, and coalescence of these micro cracks can lead to the degradation of the mechanical properties of the rock, thereby affecting the stability of the engineering structure. To establish a model that can describe the damage evolution characteristics of rocks under loading, a quantitative relationship between the damage element caused by the expansion of internal micro cracks and the overall damage of the rock is constructed based on the Weibull two‐parameter model. By introducing damage variable into the Drucker‐Prager (D‐P) criterion, an elastoplastic damage model of rock is established, and the model is redeveloped by COMSOL. The model validity is verified through triaxial test results of rock under different confining pressures. Finally, the proposed model is used to investigate the fracture characteristics of rock with prefabricated cracks, the crack stress field, crack propagation path, and failure mode of rock under uniaxial test condition are analyzed.
OTX‐2 Expression as a Diagnostic Marker for Choroid Plexus Tumors
Authors: Erşen Danyeli Ayça , Hüseyinoğlu Zeynep , Özek M. Memet 
Published: February 2025

ABSTRACTChoroid plexus tumors are neuroepithelium‐derived tumors arising in the ventricles of the central nervous system. They are commonly seen in childhood and correspond to low rates in all central nervous system tumors. Due to their rareness and similar histomorphologic features to other tumors, their diagnosis might be challenging. Here, we used the OTX‐2 antibody to evaluate the diagnostic role of OTX‐2 expression in choroid plexus tumors. We performed a retrospective review of 34 patients operated for choroid plexus tumors in our center between 2011 and 2023. Additionally, as different tumor types are also arising in the ventricles, we selected five cases each of AT/RT, germ cell tumor, ependymoma, and metastatic adenocarcinoma from the pathology archive. Immunohistochemistry conditions were adjusted for each specific antibody based on the manufacturers' recommendations for concentrations and antigen retrieval/blocking. OTX‐2, S‐100, and transthyretin antibody staining was performed on sections from each case.
Fear of Falling Avoidance Behavior on Daily Living Activities and Physical Activity in Older Adults: A Cross‐Sectional Study
Authors: Türkmen Keskin Sultan , Sönmez Sari Ebru , Canbulat Şahinde , Öztürk Fatma Özlem 
Published: February 2025

ABSTRACTThe aim of this study was to investigate the effect of avoidance behavior due to fear of falling on dependency levels in activities of daily living and physical activity levels in older adults. This study is a cross‐sectional research design. Data were collected between November 2023 and March 2024. A total of 506 individuals aged 65 years and over participated in the study (mean age 71.26). It was determined that the older adults had low level of fear of falling avoidance behaviors were fully independent in activities of daily living and had low level of physical activity. The multiple linear regression analysis showed that age, marital status, education, living with and fear of falling avoidance behavior affected daily living activities; age, place of residence, gender, income status, chronic disease status, and fear of falling avoidance behavior affected physical activity level (R2 = 0.183; R2 = 0.197, respectively). This study revealed the necessity of interventions to prevent fear of falling avoidance behaviors in order to increase the activities of daily living and physical activity levels among older adults.
Oral Health and Oral Health‐Related Beliefs in Young Adults With a Mild Intellectual Disability
Authors: de Soet Rianne , de Soet Hans J. J. , Volgenant Catherine M. C. 
Published: February 2025

ABSTRACTObjectiveOver 1.1 million people in the Netherlands have a mild intellectual disability (MID). This population also exhibits a higher prevalence of poor oral health. The present study aims to investigate the oral health status and oral health‐related beliefs of young adults with MID and co‐occurring challenges like mental health issues.Material and methodsA questionnaire was administered to 76 individuals in residential care facilities of the Salvation Army in Amsterdam, accompanied by intraoral examinations. The study group comprised young adults (ages 18–29; mean 21.7 ± 2.5 years). Data were compared with a reference group of Dutch young adults of low socioeconomic position.ResultsNo significant difference was found between the participants (4.8 ± 4.3) and the reference group (4.6; t(73) = 0.45, p > 0.05) mean DMFS scores. The average Locus of Control score (M = 23.6; scale 10–50) indicated no relationship between oral health beliefs and actual oral health status. Adjusting for whether participants had their own dentist, a weak negative correlation was observed between DMFS score and LOC (n = 30, r = −0.25, p = 0.04). The restorative care index was significantly lower in participants (33%) compared to the reference group (76%; Z = −5.72, p < 0.001).ConclusionThese findings highlight the critical need for enhanced professional oral healthcare for young adults with MID, given their compromised oral hygiene and treatment backlog. A flexible, tailored approach is essential to meet the treatment needs of this population.
Firm‐Level Concentration of Chinese Exports in Individual Markets
Authors: Yang Xuebing 
Published: February 2025

ABSTRACTThis work explores the industry‐level concentration of Chinese exports across markets. The findings of this work indicate that market size and market income level are the two key market characteristics influencing industry‐level Chinese export concentration. Increases in market size reduce Chinese export concentration, while rises in market income level amplify it. Effects of market size and income level are mediated through the quantity and heterogeneity of Chinese exporters, with the impact of the former channel dominating in both instances. Robustness tests affirm the reliability of the findings.
Simulation and modeling of the performance of energy storage tank packed with PCM
Authors: Sebbar El Hassan , Simou Zakariae , Oubenmoh Safaa , Ait Mssad Abdelouahad , Hamdaoui Said 
Published: February 2025

Abstract
Thermal energy storage systems present a multitude of possible thermal applications. It is a more effective means of narrowing the difference between supply and demand for energy. The interest generated by this technology has led to its success in many types of applications in industry. This investigation conducted a thorough parametric study of a LHS system. This system exploits the latent heat to store part of the heat transported by a HTF. The tank studied in this work was modeled in two dimensions using the CFD tool. Numerous investigations have been conducted to determine how the different factors, such as mass flow rate and HTF inlet temperature, affected the PCM change process inside the tank. The results were analyzed and discussed, including the evolution of HTF outlet temperature profiles, the liquid fraction in the capsules, the PCM temperature, and the energy stored, and the energy recovered during the charging and discharging periods. Among the results obtained, when the flow rate changes from 0.01 Kg/s to 0.03 Kg/s reduces the energy stored by all PCM capsules from 28.6920 kWh to 10.5980 kWh, and the energy recovered from 25.6422 kWh to 7.3435 kWh.