bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of vaccinations, boosters and lockdowns on COVID-19 waves in French Polynesia
Authors: Chapman Lloyd AC , Aubry Maite , Maset Noémie , Russell Timothy W , Knock Edward S , Lees John A , Mallet Henri-Pierre , Cao-Lormeau Van-Mai , Kucharski Adam J 
Published: March 2023

AbstractEstimation of the impact of vaccination and non-pharmaceutical interventions (NPIs) on COVID-19 incidence is complicated by several factors, including the successive emergence of SARS-CoV-2 variants of concern and changing population immunity resulting from vaccination and previous infection. We developed an age-structured multi-strain COVID-19 transmission model and inference framework that could estimate the impact of vaccination and NPIs while accounting for these factors. We applied this framework to French Polynesia, which experienced multiple large COVID-19 waves from multiple variants over the course of the pandemic, interspersed with periods of elimination. We estimated that the vaccination programme averted 49.6% (95% credible interval (CI) 48.7–50.5%) of the 5830 hospitalisations and 64.2% (95% CI 63.1–65.3%) of the 1540 hospital deaths that would have occurred in a baseline scenario without any vaccination up to May 2022. Vaccination also averted an estimated 34.8% (95% CI 34.5–35.2%) of 223,000 symptomatic cases in the baseline scenario. We estimated the booster campaign contributed 4.5%, 1.9% and 0.4% to overall reductions in cases, hospitalisations and hospital deaths respectively. Our results suggested that removing, or altering the timings of, the lockdowns during the first two waves had non-linear effects on overall incidence owing to the resulting effect on accumulation of population immunity. Our estimates of vaccination and booster impact differ from those for other countries due to differences in age structure, previous exposure levels and timing of variant introduction relative to vaccination, emphasising the importance of detailed analysis that accounts for these factors.
FADD- and RIPK3-mediated cell death ensures timely clearance of wound macrophages and promotes wound healing
Authors: Injarabian Louise , Willenborg Sebastian , Welcker Daniela , Pasparakis Manolis , Kashkar Hamid , Eming Sabine A 
Published: March 2023

AbstractCells of the monocyte/macrophage lineage are an integral component of the body’s innate ability to restore tissue function after injury. In parallel to mounting an inflammatory response, clearance of monocytes/macrophages from the wound site is critical to re-establish tissue functionality and integrity during the course of healing. The role of regulated cell death in macrophage clearance from damaged tissue and its implications for the outcome of the healing response is little understood. Here, we explored the role of macrophage-specific FADD-mediated cell death onRipk3-/-background in a mechanical skin injury model in mice. We found that combined inhibition of RIPK3-mediated necroptosis and FADD-caspase-8-mediated apoptosis in macrophages profoundly delayed wound healing. Importantly, RIPK3 deficiency alone did not considerably alter the wound healing process and macrophage population dynamics, arguing that inhibition of FADD-caspase-8-dependent death of macrophages is primarily responsible for the delayed wound closure. Notably, TNF blockade reversed the accumulation of Ly6Chighmacrophages induced by combined deficiency of FADD and RIPK3, indicating a critical dual role of TNF-mediated pro-survival and cell death signalling, particularly in this highly pro-inflammatory macrophage subset. Our findings reveal a previously uncharacterized cross-talk of inflammatory and cell death signalling in macrophages in regulating repair processes in the skin.
Modeling and predicting meat yield and growth performance using morphological features of narrow-clawed crayfish with machine learning techniques
Authors: Gültepe Yasemin , Berber Selçuk , Gültepe Nejdet 
Published: March 2023

AbstractIn this study, predictions of length-weight relationships and meat productivity were generated by machine learning models using measurement data of male and female crayfish in the narrow-clawed crayfish population living in Apolyont Lake. The data set was created using the growth performance and morphometric characters obtained from 1416 crayfish in different years to determine the length-weight relationship and length-meat yield. Statistical methods, artificial intelligence, and machine learning are used due to the difficulty of constructing mathematical models in multi-parameter and multivariate problems. In recent studies, artificial intelligence and machine learning methods give higher accuracy than other prediction methods in large data sets with complex structures. No previous studies have been conducted on such population parameters. The analysis results show that most of the models designed as an alternative to traditional estimation methods in future planning studies in sustainable fisheries, aquaculture, and natural sources management are valid for machine learning and artificial intelligence. Seven different machine learning algorithms were applied to the data set and the length-weight relationships and length-meat yields were evaluated for both male and female individuals. Support Vector Regression (SVR) has achieved the best prediction performance with 0.996 and 0.992 values for the length-weight of males and females, with 0.996 and 0.995 values for the length-meat yield of males and females. The results showed that the SVR outperforms the others for all scenarios regarding the accuracy, sensitivity, and specificity metrics.
Mechanistic and evolutionary insights into isoform-specific ‘supercharging’ in DCLK family kinases
Authors: Venkat Aarya , Watterson Grace , Byrne Dominic P. , O’Boyle Brady , Shrestha Safal , Gravel Nathan , Fairweather Emma E. , Daly Leonard A. , Bunn Claire , Yeung Wayland , Aggarwal Ishan , Katiyar Samiksha , Eyers Claire E. , Eyers Patrick A. , Kannan Natarajan 
Published: March 2023

AbstractCatalytic signaling outputs of protein kinases are dynamically regulated by an array of structural mechanisms, including allosteric interactions mediated by intrinsically disordered segments flanking the conserved catalytic domain. The Doublecortin Like Kinases (DCLKs) are a family of microtubule-associated proteins characterized by a flexible C-terminal autoregulatory ‘tail’ segment that varies in length across the various human DCLK isoforms. However, the mechanism whereby these isoform-specific variations contribute to unique modes of autoregulation is not well understood. Here, we employ a combination of statistical sequence analysis, molecular dynamics simulations andin vitromutational analysis to define hallmarks of DCLK family evolutionary divergence, including analysis of splice variants within the DCLK1 sub-family, which arise through alternative codon usage and serve to ‘supercharge’ the inhibitory potential of the DCLK1 C-tail. We identify co-conserved motifs that readily distinguish DCLKs from all other Calcium Calmodulin Kinases (CAMKs), and a ‘Swiss-army’ assembly of distinct motifs that tether the C-terminal tail to conserved ATP and substrate-binding regions of the catalytic domain to generate a scaffold for auto-regulation through C-tail dynamics. Consistently, deletions and mutations that alter C-terminal tail length or interfere with co-conserved interactions within the catalytic domain alter intrinsic protein stability, nucleotide/inhibitor-binding, and catalytic activity, suggesting isoform-specific regulation of activity through alternative splicing. Our studies provide a detailed framework for investigating kinome–wide regulation of catalytic output through cis-regulatory events mediated by intrinsically disordered segments, opening new avenues for the design of mechanistically-divergent DCLK1 modulators, stabilizers or degraders.
TTG2defines trichome cell shape by modulating microtubules and actin cytoskeleton in Arabidopsis
Authors: Liu Lu , Cao Weihua , Yuan Lanxin , Yang Lan , Wang Yali , Zhang Chi , Wang Dan , Wang Wenjia , Zhang Hongchang , Schiefelbein John , Yu Fei , An Lijun 
Published: March 2023

AbstractThe ArabidopsisTRANSPARENT TESTA GLABRA2(TTG2) gene encodes a WRKY transcription factor that regulates a range of development events like trichome, seed coat, and atrichoblasts formation. Loss-of-function ofTTG2was previously shown to reduce or eliminate trichome branching. Here, we report the identification of a new allele ofTTG2,ttg2-6. In contrast to thettg2mutants described before,ttg2-6displays unique trichome phenotypes. Somettg2-6mutant trichomes are hyperbranched, whereas others are hypobranched, distorted, or clustered. Further, we found that in addition to specifically activating R3 MYB transcription factorTRIPTYCHON(TRY) to promote trichome branching,TTG2also integrates cytoskeletal signaling to regulate trichome morphogenesis. Thettg2-6trichomes display aberrant cortical microtubules (cMTs) and cortical actin filaments (F-actin) configurations. Moreover, genetic and biochemical analysis showed that TTG2 could directly bind and regulate the expression ofBRICK1(BRK1), a subunit of the actin nucleation promoting complex SCAR/WAVE. Collectively, taking advantage ofttg2-6, we uncovered new functions forTTG2in facilitating cMT and F-actin cytoskeleton-dependent trichome development. Our evidence for a direct relationship betweenTTG2and cytoskeletal regulators establishes an unprecedented understanding of cellular signaling events downstream of the core transcriptional regulation during trichome development in Arabidopsis.
A comparison of the environmental impact of turboprop and turbofan-powered aircraft
Authors: Kilic Ugur 
Published: March 2023

Purpose
This study aims to examine turboprop- and turbofan-powered aircraft, with the same seating capacity flying on the same route and trajectory, and investigate their environmental effects.

Design/methodology/approach
The integrated aircraft noise and emissions modeling platform developed by EUROCONTROL is used for the calculation of fuel burn, CO2, H2O and other gas emissions (NOx, SOx, CO, HC, soot and other trace compounds) for the per phase of flight.

Findings
The striking findings are that turboprop-powered aircraft offer lower required thrust, fuel consumption and total emissions for a short-haul flight, but turbofan-powered aircraft have lower particulate matter, CO and HC emissions than turboprop-powered aircraft. This study suggests that turboprop-powered aircraft are superior to turbofan-powered aircraft in terms of environmental impact for a short-haul flight.

Practical implications
The current research conducts comprehensively fuel consumption and amounts of emissions aspects of turboprop- and turbofan-powered aircraft for sustainable development of airlines by a versatile simulation approach and sheds light on airlines intending to create fleets.

Originality/value
The research offers a systematic aircraft selection for investigators, scientists, airline operators, policy analysts and legislators, by a comprehensive computer simulation method that acknowledges consistently the fuel consumption and detailed emissions analysis of turboprop- and turbofan-powered aircraft.
Motivations for the initiation of knowledge management activities in times of routine and emergency
Authors: Nakash Maayan , Bouhnik Dan 
Published: March 2023

PurposeThis research seeks to understand, for the first time, what motivates knowledge-intensive organizations (KIOs) to initiate knowledge management (KM) activities in times of routine and emergency. The COVID-19 pandemic was placed at the center as a case study of an extreme crisis.Design/methodology/approachBased on the adoption of the qualitative-constructivist paradigm, the study was conducted among 52 KM professionals through in-depth interviews and focus groups. The data were analyzed using a thematic analysis method, according to the principles of the grounded theory approach.FindingsThe findings reveal that opportunities and risks are two types of catalysts which accelerate KM efforts in times of routine and emergency respectively. Due to KM’s support of the transition to flexible employment during COVID-19, the authors show that this field experienced real growth and prosperity in the “new normal.” KM initiatives were promoted during the COVID-19 crisis in light of gaps in retention, sharing, accessibility and development of knowledge.Originality/valueGiven that knowledge risks are a field with fragmented understanding, the results contribute to understanding the importance of risk management related to knowledge in times of crises and turmoil. The authors call for incorporating this niche into the overall risk management of the organization, while adopting a holistic and long-term perspective of KM. Furthermore, the authors uncover KM’s position in KIOs during the global pandemic. The paper proposes food for thought regarding informal knowledge sharing in virtual environments typical of the “Corona routine”.
Green food purchasing behaviour: a multi-method approach of Generation Y in a developing country
Authors: Synodinos Costa , Moraes Gustavo Hermínio Salati Marcondes de , Prado Nágela Bianca do 
Published: March 2023

PurposeThis research aimed to analyse the antecedents of green food purchasing behaviour amongst Generation Y consumers in a developing country. More specifically, the authors investigated the influence of attitudes towards organic food, subjective norms, perceived behaviour control, environmental knowledge, health awareness and organic food knowledge on the purchase intention of organic food and, consequently, organic food purchase behaviour.Design/methodology/approachA multi-method approach combined symmetric techniques with partial least squares structural equation modelling (PLS-SEM) and asymmetric techniques with fuzzy-set qualitative comparative analysis (fsQCA). The primary data sample was collected by a specialist company and included 500 Generation Y consumers from South Africa.FindingsPLS-SEM results confirmed the positive influence of all antecedents, confirming the hypotheses. The authors also identified a multiple full mediation of environmental knowledge and health consciousness in the relationship between subjective norms and purchase intention. The fsQCA results indicated six different sufficient configurations for a high level of purchase intention, indicating that only some of the constructs are essential to stimulate the intention.Originality/valueThe originality of the research lies in presenting a new perspective on the sustainable consumption behaviour of Generation Y in a developing country, with a combination of techniques that provide greater robustness to the results. Specifically, the authors contribute to the debate on consumer behaviour and sustainability issues by understanding the dynamics between the factors that drive the purchase behaviour of green products. The article also contributes empirical results that help achieve Sustainable Development Goals (SDGs).
A study on the determinants of successful performance of Indonesian cooperatives
Authors: Kusmiati Eti , Masyita Dian , Febrian Erie , Cahyandito Martha Fani 
Published: March 2023

PurposeThe purpose of this study is to look at the factors that influence the success of Indonesian cooperatives.Design/methodology/approachThis study employs a two-stage quantitative approach. Exploratory factor analysis (EFA) is used to determine the factors in the first step. The next step is to conduct a multivariate regression analysis to determine the impact of these factors on the cooperative success variable in Indonesia.FindingsThe components produced include Member Participation, Membership, Cooperative Governance Structure, Board of co-ops, Vertical Integration, Collective Action and Transaction Cost, according to the EFA results. A further study utilizing multiple regression techniques reveals that four elements, namely Member Participation, Board of Coops, Vertical Integration and Collective Action, have a major impact on the performance of Indonesian cooperatives.Research limitations/implicationsGeneralizations are impossible because of the small sample size and restricted responders. More studies are required, using a broader range of respondents and approaches.Practical implicationsThe results of the study contributed both to the stakeholders of cooperatives and to the development of cooperative science specifically in the context of Indonesian cooperatives. Cooperative stakeholders in Indonesia must realize that members are owners and customers of their cooperative. This awareness must continue to be echoed by cooperatives to its members in various ways, so that commitment arises to members to be willing to participate and cooperate. Awareness of members to participate and cooperate ultimately affects the sustainability of cooperative businesses and impacts improving members' welfare beds.Originality/valueThe study's novelty lies in a more comprehensive model of Indonesian cooperative success.Peer reviewThe peer review history for this article is available at: https://publons.com/publon/10.1108/IJSE-02-2022-0078.
Internationalisation, sustainability and the contested environmental impacts of international student mobility
Authors: McCollum David , Nicholson Hebe 
Published: March 2023

Purpose
This paper aims to stimulate the nascent research agenda on the environmental sustainability of the ongoing mushrooming of international student mobility (ISM). The higher education (HE) system in the UK and elsewhere is increasingly predicated upon the hosting of international students. Whilst this drive towards internationalisation undoubtably has multiple benefits, little attention thus far has been paid to its potentially very considerable environmental impact. The drive for internationalisation within HE thus potentially sits at odds with ambitions and strategies to promote sustainability within the sector and beyond.

Design/methodology/approach
In-depth interviews with 21 students and representatives of 14 university international offices offer insights into how the environment features in the decisions that young people and HE institutions make with regards to partaking in and promoting education-related mobility.

Findings
The results find that students take environmental considerations into account when undertaking education-related mobility, but these aspirations are often secondary to logistical issues concerning the financial cost and longer travel times associated with greener travel options. At the institutional scale, vociferously championed university sustainability agendas have yet to be reconciled with the financial imperative to recruit evermore international students.

Originality/value
This paper identifies a thus far neglected contradiction within HE whereby the sustainability agenda that it so rightly espouses is potentially undermined by the drive towards internationalisation. The paper uses the anthropause concept to consider the future environmental sustainability of ISM.
Beyond imaging: drones for physical applications
Authors: Bogue Robert 
Published: March 2023

Purpose
This paper aims to illustrate the growing role of drones in applications involving physical tasks.

Design/methodology/approach
Following a short introduction, this first provides a brief introduction to drone technology. It then describes and discusses products and applications involving physical tasks in agricultural and forestry, maritime rescue, firefighting and product delivery. Finally, brief conclusions are drawn.

Findings
Excluding military applications, drones were initially used primarily for image acquisition. Numerous different designs have since been developed with greatly varying wing configurations, payloads, flight duration, power sources and other features which are increasingly being used to conduct physical tasks. In the applications considered here drones are applying agrochemicals and dispersing crop and tree seeds; saving lives by deploying lifeboats and buoyancy aids; extinguishing fires in high-rise buildings and forests; and delivering groceries, food, mail, medicines and humanitarian aid, often in and to remote locations.

Originality/value
This study provides a detailed insight into selection of applications in which drones conduct physical tasks.
Efficiency and price clustering in Islamic stocks: evidence from three Asian countries
Authors: Lobão Júlio 
Published: March 2023

Purpose
This paper aims to examine the extent of price clustering in a selection of Islamic stocks listed in Indonesia, Malaysia and Pakistan and also investigates the determinants of the phenomenon at the firm level.

Design/methodology/approach
The author test the uniformity of price distribution in the selected securities. Then, the determinants of price clustering were investigated through multivariate analysis based on a binary logistic regression model. Following the arguments of Narayan et al. (2011), who emphasize the importance of considering firm heterogeneity when studying the phenomenon, the author conducts the empirical study at the firm level.

Findings
The evidence indicates that Islamic stocks show a mild level of price clustering. Only half of the stocks under analysis rejected the uniformity test in the distribution of prices. In these cases, investors exhibited a preference for prices ending at zero and five. The evidence does not confirm the cultural clustering theories. Price clustering is found to be positively associated with price level and relative bid-ask spread. Overall, the negotiation hypothesis, which predicts that investors prefer round prices to minimize the costs associated with negotiations, best explains most of our results.

Research limitations/implications
The existence of price clustering is difficult to reconcile with the prediction of the efficient market hypothesis that prices should follow a random walk. Moreover, the evidence indicates that Muslim investors share a preference for round prices in some settings, under the assumption that Islamic stocks are mostly traded by Muslim investors.

Originality/value
To the author’s best knowledge, this is the first study to address the subject of price clustering in Islamic stocks.