bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of Demand for Fish in Urban Malawi
Authors: Banda Fredrick Mangwaya , Edriss Abdi-Khalil 
Published: September 2023

The purpose of this study was to find the drivers of demand for various fish species in urban Malawi. Previous demand studies on the fisheries sector in Malawi have, mainly, treated fish as a homogenous commodity thereby making information regarding households’ general consumption patterns for different fish species scanty. This study, therefore, concentrates on the disaggregated analysis of the demand for the major fish species caught and consumed in Malawi. It focuses on fish from both capture fishery and aquaculture sub-sectors namely; Engraulicypris sardella (usipa), Copadichromis spp (utaka), Lethrinops spp (kambuzi); Clarias gariepinus (mlamba); Rhamphochromis spp (mcheni); Barbus Paludinosus (matemba); and Lake Malawi tilapia (chambo). It employs primary data collected from the households in Blantyre city using a multistage stratified random sampling method. Results show that the demand for usipa is influenced by a household’s location in a high-density area, and has low-income levels. Utaka, on the other hand, is positively influenced by the age of the household head and the number of people employed in the household while chambo is positively influenced by the high education level of the household head, high-income levels, and the household’s location in the high-density areas. The study has also found that mcheni and mlamba are positively influenced by income levels while the demand for matemba is positively the household head’s state of being married but it is negatively influenced by the number of children in the household. Policy implications arising from this study are that in the course of carrying out market segmentation, the fish marketers in Malawi must concentrate on selling usipa to households in high-density areas and focus on households with low-income levels. The selling of utaka while chambo should mainly be sold to households whose heads have high education, have high-income levels, and are located in high-density areas.
Earnings Quality Research: Trend, Recent Evidence and Future Direction
Authors: Fonou Dombeu Nyanine Chuele , Nomlala Bomi Cyril 
Published: September 2023

This paper provided an overview of earnings quality research by assessing whether area of future research and challenge identified in prior studies have been addressed in the literature. Specifically, the study discussed two areas of earnings quality that have received attention in the last decade: the impact of fair value accounting on earnings quality and the models used to measure accrual quality. A comment on earnings quality during the COVID-19 pandemic is also provided. The study revealed that fair value accounting affect earnings quality and the empirical results on the effect of fair value on earnings quality are mixed and depend on the environment in which the firm operates. The study also showed that, earlier models used to measure accrual quality are still currently been used and the literature has evolved to take into consideration the innate and discretionary components of earnings quality. However, it is still not clear whether the models used to separate earnings quality into its components are effective. This paper contributes to knowledge by synthesizing new insight into the current state of knowledge on some aspects of earnings quality research. The study further identified unanswered questions in the field, which provides direction for future studies.
PElATIHAN KETERAMPILAN SPEADSHEET PADA PELAKU INDUSTRI RUMAHAN PADA BUMDES DI DESA TERU
Authors: Sulaiman Rahmat , Sugihartono Tri , Raya Agustina Mardeka 
Published: September 2023

BUMDES merupakan usaha desa yang dikelola oleh Pemerintah Desa, dan berbadan hukum. Pemerintah Desa dapat mendirikan Badan Usaha Milik Desa sesuai dengan kebutuhan dan potensi Desa. Pembentukan Badan Usaha Milik Desa ditetapkan dengan Peraturan Desa. Kepengurusan Badan Usaha Milik Desa terdiri dari Pemerintah Desa dan masyarakat desa setempat. Badan Usaha Milik Desa pada Desa Teru bertujuan untuk membangun kreatifitas masyarakat yang ada di Desa Teru, termasuk dalam penggunaan Teknologi yang ada. Selain itu BUMDES juga mempunyai andil dalam pengembangan sumber daya manusia yang ada di Desa Teru tersebut. Sehingga BUMDES Desa Teru melakukan pelatihan MS.Excel Spreadsheet kepada pelaku BUMDES Desa Teru sebagai bekal dan pondasi dalam mengolah angka yang akan digunakan sebagai dasar untuk laporan keuangan pada industri kreatis BUMDES Desa Teru. Pelatihan ini dilaksanakan dalam waktu Dua Hari pada Kantor Desa Teru. Tujuan dari Kegiatan pelatihan Spreadsheet ini adalah untuk memberikan pengetahuan dasar kepada Pelaku Industri Kreatif Rumahan BUMDES Desa Teru agar mengerti mengolah angka secara otomatis yang nantinya akan digunakan sebagai laporan keuangan mereka. Dari beberapa peserta pelatihan mereka cukup antusias terhadap acara ini dan menganjurkan untuk dibuatkan acara serupa sebagai tindak lanjut terhadap acara ini.
Recensioni
Authors: Tosi Silvia , Bloom Dan , Grech Marialuisa 
Published: September 2023

Pizzimenti M., Bellini B. (2022). Sessuologia della Gestalt. Manuale imperfetto per continuare la rivoluzione sessuale. Con i contributi di Sara Bouchard e Flavia Mahnic. Milano: FrancoAngeli Editore. ISBN: 978-88-351-3507-4, pp. 258, € 32,00Bramucci A. (2022). Dipendo dunque esisto. L'addiction attraverso la Gestalt e non solo. Assisi: Cittadella Editrice. ISBN: 978-88-308-1824-8, pp. 200, € 15,90
Pemberdayaan Masyarakat Melalui Pengelolaan Sampah Berbasis Pembuatan Lubang Resapan Biopori Di Desa Manikliyu, Bangli
Authors: Putra I Gusti Agung Ananda 
Published: September 2023

Masalah sampah di Indonesia sangat kompleks. Pencemaran laut, pencemaran sungai, penghentian proses air tanah, dan pencemaran tanah adalah beberapa masalah sampah yang dapat membahayakan lingkungan. Di Desa Manikliyu, Kecamatan Kintamani, Kabupaten Bangli, Provinsi Bali, program pengabdian masyarakat ini bertujuan untuk memberdayakan masyarakat melalui pengeloaan sampah berbasis pembuatan lubang resapan berpori. Hasil kegiatan menunjukkan bahwa masyarakat Desa Manikliyu akan lebih memahami manfaat dan teknik pembuatan lubang resapan berpori untuk mendukung pelestarian lingkungan.
Bone marrow mesenchymal stem cell exosomes-derived microRNA-216a-5p on locomotor performance, neuronal injury, and microglia inflammation in spinal cord injury
Authors: Xue Hao , Ran Bo , Li Jie , Wang Guorui , Chen Baolin , Mao Honggang 
Published: September 2023

Background: MicroRNA-216a-5p (miR-216a-5p) mediates inflammatory responses and neuronal injury to participate in the pathology of spinal cord injury (SCI). This study intended to explore the engagement of bone marrow mesenchymal stem cell exosomes (BMSC-Exo)-derived miR-216a-5p in locomotor performance, neuronal injury, and microglia-mediated inflammation in SCI rats.Methods: Rat BMSC or BMSC-Exo was injected into SCI rats. GW4869 treatment was adopted to suppress the exosome secretion from BMSC. Subsequently, miR-216a-5p-overexpressed BMSC-Exo (BMSC-miR-Exo) or negative-control-overexpressed BMSC-Exo (BMSC-NC-Exo) were injected into SCI rats.Results: The injection of BMSC or BMSC-Exo enhanced locomotor performance reflected by Basso, Beattie &amp; Bresnahan score (p &lt; 0.001), and neuronal viability reflected by NeuN+ cells (p &lt; 0.01), but attenuated neuronal apoptosis reflected by TUNEL positive rate, cleaved-caspase-3 expression, and B-cell leukemia/lymphoma-2 expression (p &lt; 0.05). Additionally, the injection of BMSC or BMSC-Exo suppressed microglia M1 polarization-mediated inflammation reflected by IBA1+iNOS+ cells, tumor necrosis factor-α, interleukin (IL)-1β, and IL-6 (p &lt; 0.01). Notably, the effect of BMSC on the above functions was retarded by the GW4869 treatment (most p &lt; 0.05). Subsequently, the injection of BMSC-miR-Exo further improved locomotor performance (p &lt; 0.05), while inhibiting neuronal apoptosis (p &lt; 0.05) and microglia M1 polarization-mediated inflammation (p &lt; 0.05) compared to BMSC-NC-Exo. Interestingly, the injection of BMSC-miR-Exo reduced toll-like receptor 4 (TLR4) (p &lt; 0.01), myeloid differentiation factor 88 (p &lt; 0.05), and nuclear factor kappa B (NF-κB) (p &lt; 0.05) expressions versus BMSC-NC-Exo.Conclusion: BMSC-Exo-derived miR-216a-5p enhances functional recovery by attenuating neuronal injury and microglia-mediated inflammation in SCI, which may be attributable to its inhibition of the TLR4/NF-κB pathway.
Tanshinone IIA inhibits cardiomyocyte pyroptosis through TLR4/NF-κB p65 pathway after acute myocardial infarction
Authors: Chai Ruoning , Ye Zelin , Xue Wenjing , Shi Shuqing , Wei Yi , Hu Yuanhui , Wu Huaqin 
Published: September 2023

Background: Tanshinone IIA, derived from Radix Salviae Miltiorrhizae (Salvia miltiorrhiza Bunge), constitutes a significant component of this traditional Chinese medicine. Numerous studies have reported positive outcomes regarding its influence on cardiac function. However, a comprehensive comprehension of the intricate mechanisms responsible for its cardioprotective effects is still lacking.Methods: A rat model of heart failure (HF) induced by acute myocardial infarction (AMI) was established via ligation of the left anterior descending coronary artery. Rats received oral administration of tanshinone IIA (1.5 mg/kg) and captopril (10 mg/kg) for 8 weeks. Cardiac function was assessed through various evaluations. Histological changes in myocardial tissue were observed using staining techniques, including Hematoxylin and Eosin (HE), Masson, and transmission electron microscopy. Tunel staining was used to detect cell apoptosis. Serum levels of NT-pro-BNP, IL-1β, and IL-18 were quantified using enzyme-linked immunosorbent assay (ELISA). Expression levels of TLR4, NF-κB p65, and pyroptosis-related proteins were determined via western blotting (WB). H9C2 cardiomyocytes underwent hypoxia-reoxygenation (H/R) to simulate ischemia-reperfusion (I/R) injury, and cell viability and apoptosis were assessed post treatment with different tanshinone IIA concentrations (0.05 μg/ml, 0.1 μg/ml). ELISA measured IL-1β, IL-18, and LDH expression in the cell supernatant, while WB analysis evaluated TLR4, NF-κB p65, and pyroptosis-related protein levels. NF-κB p65 protein nuclear translocation was observed using laser confocal microscopy.Results: Tanshinone IIA treatment exhibited enhanced cardiac function, mitigated histological cardiac tissue damage, lowered serum levels of NT-pro-BNP, IL-1β, and IL-18, and suppressed myocardial cell apoptosis. Moreover, tanshinone IIA downregulated the expression of TLR4, NF-κB p65, IL-1β, pro-IL-1β, NLRP3, Caspase-1, and GSDMD-N pyroptosis-related proteins in myocardial tissue. Additionally, it bolstered H/R H9C2 cardiomyocyte viability, curbed cardiomyocyte apoptosis, and reduced the levels of TLR4, NF-κB p65, IL-1β, pro-IL-1β, NLRP3, Caspase-1, and GSDMD-N pyroptosis-related proteins in H/R H9C2 cells. Furthermore, it hindered NF-κB p65 protein nuclear translocation.Conclusion: These findings indicate that tanshinone IIA enhances cardiac function and alleviates myocardial injury in HF rats following AMI. Moreover, tanshinone IIA demonstrates potential suppression of cardiomyocyte pyroptosis. These effects likely arise from the inhibition of the TLR4/NF-κB p65 signaling pathway, presenting a promising therapeutic target.
The prevalence of cardiorenal anemia syndrome among patients with heart failure and its association with all-cause hospitalizations: a retrospective single-center study from the Middle East
Authors: Manla Yosef , Kholoki Obada , Bader Feras , Kanwar Oshin , Abidi Emna , El Nekidy Wasim S. , Hijazi Fadi , Attallah Nizar 
Published: September 2023

Background and aimLittle is known about the burden of cardiorenal syndrome (CRS) and cardiorenal anemia syndrome (CRAS) in the Middle East Region. Furthermore, whether the occurrence rates of CRAS differ across heart failure (HF) phenotypes is not widely investigated. We aimed to examine the prevalence of CRS and CRAS in patients with HF, compare characteristics of patients with CRAS-HFrEF vs. CRAS-HFpEF, and investigate anemia association with 1-year all-cause hospitalizations.MethodsHF patients who visited a multidisciplinary HF clinic at a single center between 10-2015 and 06-2022 (n = 968) were retrospectively included. Differences in rates of CRAS prevalence, and patients’ characteristics of those with CRAS-HFrEF vs. CRAS-HFpEF were determined using appropriate testing methods. Generalized estimating equation (GEE) models were used to determine if anemia was associated with higher rates of hospitalization.ResultsCRS was prevalent in 34.4% of subjects, while 25.3% had CRAS. CRAS prevalence rates among patients with HFpEF vs. HFrEF were comparable (27.2% vs. 24.2%, p = 0.3). Compared to patients with HFrEF-CRAS, those with HFpEF-CRAS were more likely females (p &lt; 0.001), had a higher burden of hypertension (p = 0.01), and lower hemoglobin (p = 0.02). In an adjusted GEE model, anemia was associated with an average increase of 1.8 admissions in CRS patients (p = 0.015).ConclusionIn patients with HF, 1 in 3 patients presented with CRS, and 1 in 4 patients had CRAS. The prevalence of CRAS was comparable among those HFpEF and HFrEF. Anemia was associated with an increased rate of 1-year all-cause hospitalization in CRS patients.
CT-guided paravertebral injection of doxorubicin for treatment of postherpetic neuralgia: a database-based retrospective stratified study
Authors: Lu Fan , Zhong JiWei , Liu Hui , Xiao Hong 
Published: September 2023

ObjectiveThis study explored the impact of different doeses of doxorubicin in CT-guided transvertebral foraminal injections for postherpetic neuralgia (PHN) treatment and the impact of 0.5% doxorubicin treatment on patients with different disease courses and lesion locations.MethodsThis retrospective study included 291 patients with PHN who received CT-guided doxorubicin injection at West China Hospital between April 2014 and February 2020.ResultsA total of 228 patients received 0.5% doxorubicin treatment and 63 received 0.33% doxorubicin. Both groups showed significantly improvement in visual analogue scale (VAS) and Brief Pain Inventory (BPI) scores. The 0.5% doxorubicin group demonstrated significant lower VAS scores at 6 and 12 months after surgery (all p &lt; 0.001) and a significant lower score on the BPI at 6 and 12 months than the 0.33% doxorubicin group (all p &lt; 0.05). Stratified analysis of 0.5% doxorubicin demonstrated a significant reduction in VAS score at 1 week, 3 months, 6 months, and 12 months after treatment compared to baseline (all p &lt; 0.05) and significant improvements in BPI score after treatment compared to baseline (p &lt; 0.05). The VAS score of the chest group was significant higher than facial, neck and upper limbs and abdomen groupsin groups 1 week after surgery (all p &lt; 0.05). Various aspects of quality of life, including daily life, enjoyment of life, sleep, relationships, work, walking ability, and emotions, significantly decreased after surgery (p &lt; 0.05). Especially in sleep duration, there was an increase in patients reporting intermediate sleep (4–7 h) and a proportion achieving a normal sleep duration of ≥7 h. And no significant differences of BPI were observed among different affected locations. The incidence of adverse events in the 0.5% doxorubicin group and 0.33% doxorubicin group was 8.78 and 6.34%, respectively.ConclusionCT-guided doxorubicin injection therapy has the potential to alleviate pain and enhance the quality of life in patients with PHN. Notably, the use of a 0.5% doxorubicin concentration yields more pronounced pain relief compared to a 0.33% concentration. While longer durations of PHN and specific affected sites may influence the response to treatment, the overall improvements in quality of life remain consistent.
Propranolol treatment during repetitive mild traumatic brain injuries induces transcriptomic changes in the bone marrow of mice
Authors: Smith Jared A. , Nguyen Tyler , Davis Brittany C. , Lahiri Debomoy K. , Hato Takashi , Obukhov Alexander G. , White Fletcher A. 
Published: September 2023

IntroductionThere are 1.5 million new mild traumatic brain injuries (mTBI) annually in the US, with many of the injured experiencing long-term consequences lasting months after the injury. Although the post injury mechanisms are not well understood, current knowledge indicates peripheral immune system activation as a causal link between mTBI and long-term side effects. Through a variety of mechanisms, peripheral innate immune cells are recruited to the CNS after TBI to repair and heal the injured tissue; however, the recruitment and activation of these cells leads to further inflammation. Emerging evidence suggests sympathetic nervous system (SNS) activity plays a substantial role in the recruitment of immune cells post injury.MethodsWe sought to identify the peripheral innate immune response after repeated TBIs in addition to repurposing the nonselective beta blocker propranolol as a novel mTBI therapy to limit SNS activity and mTBI pathophysiology in the mouse. Mice underwent repetitive mTBI or sham injury followed by i.p. saline or propranolol. Isolated mRNA derived from femur bone marrow of mice was assayed for changes in gene expression at one day, one week, and four weeks using Nanostring nCounter® stem cell characterization panel.ResultsDifferential gene expression analysis for bone marrow uncovered significant changes in many genes following drug alone, mTBI alone and drug combined with mTBI.DiscussionOur data displays changes in mRNA at various timepoints, most pronounced in the mTBI propranolol group, suggesting a single dose propranolol injection as a viable future mTBI therapy in the acute setting.
Metabolic syndrome, adiposity, diet, and emotional eating are associated with oxidative stress in adolescents
Authors: Ramírez-Garza Sonia L. , Laveriano-Santos Emily P. , Moreno Juan J. , Bodega Patricia , de Cos-Gandoy Amaya , de Miguel Mercedes , Santos-Beneit Gloria , Fernández-Alvira Juan Miguel , Fernández-Jiménez Rodrigo , Martínez-Gómez Jesús , Ruiz-León Ana María , Estruch Ramon , Lamuela-Raventós Rosa M. , Tresserra-Rimbau Anna 
Published: September 2023

BackgroundMetabolic syndrome (MS), a condition related to adiposity and oxidative stress, can develop in adolescence, a critical stage in life that impacts health in adulthood. However, there is scarce scientific research about the relationship between lifestyle factors, emotion management, and oxidative stress in this phase of life.AimTo analyze whether nutritional parameters, lifestyle factors, emotion management, and MS in adolescents are associated with oxidative stress measured by the biomarker 8-isoprostane.MethodsA cross-sectional study was carried out in 132 adolescents (48.5% girls, aged 12 ± 0.48 years) and data were collected on nutritional parameters (anthropometric measurements, biochemical analyzes, and blood pressure), lifestyle factors (physical activity, sleep, and diet), and emotion management (self-esteem, emotional eating, and mood). 8-isoprostane was analyzed in spot urine samples. The study population was categorized in three groups (healthy, at-risk, and with MS) using the International Diabetes Federation definition of MS in adolescents. To capture more complex interactions, a multiple linear regression was used to analyze the association between 8-isoprostane and the aforementioned variables.ResultsUrinary 8-isoprostane levels were significantly higher in the MS group compared to the healthy group (1,280 ± 543 pg./mg vs. 950 ± 416 pg./mg respectively). In addition, univariable analysis revealed positive significant associations between 8-isoprostane and body mass index, waist circumference, waist-to-height ratio, body fat percentage, blood lipid profile and glucose, emotional eating, and refined cereal intake. Conversely, a negative significant association was found between 8-isoprostane and sleep duration and fish intake. The multiple linear regression analysis revealed associations between 8-isoprostane and LDL-c (β = 0.173 value of p = 0.049), emotional eating (low β = 0.443, value of p = 0.036; high β = 0.152, value of p = 0.470), refined cereal intake (β =0.191, value of p = 0.024), and fish intake (β = −0.187, value of p = 0.050).ConclusionThe MS group, LDL-c, emotional eating, and high refined cereals and low fish intakes were associated with higher levels of oxidative stress in an adolescent population.
Increasing temperature-driven changes in life history traits and gene expression of an Antarctic tardigrade species
Authors: Giovannini Ilaria , Manfrin Chiara , Greco Samuele , Vincenzi Joel , Altiero Tiziana , Guidetti Roberto , Giulianini Piero , Rebecchi Lorena 
Published: September 2023

The Antarctic region has been experiencing some of the planet’s strongest climatic changes, including an expected increase of the land temperature. The potential effects of this warming trend will lead ecosystems to a risk of losing biodiversity. Antarctic mosses and lichens host different microbial groups, micro-arthropods and meiofaunal organisms (e.g., tardigrades, rotifers). The eutardigrade Acutuncus antarcticus is considered a model animal to study the effect of increasing temperature due to global warming on Antarctic terrestrial communities. In this study, life history traits and fitness of this species are analyzed by rearing specimens at two different and increasing temperatures (5°C vs. 15°C). Moreover, the first transcriptome analysis on A. antarcticus is performed, exposing adult animals to a gradual increase of temperature (5°C, 10°C, 15°C, and 20°C) to find differentially expressed genes under short- (1 day) and long-term (15 days) heat stress. Acutuncus antarcticus specimens reared at 5°C live longer (maximum life span: 686 days), reach sexual maturity later, lay more eggs (which hatch in longer time and in lower percentage) compared with animals reared at 15°C. The fitness decreases in animals belonging to the second generation at both rearing temperatures. The short-term heat exposure leads to significant changes at transcriptomic level, with 67 differentially expressed genes. Of these, 23 upregulated genes suggest alterations of mitochondrial activity and oxido-reductive processes, and two intrinsically disordered protein genes confirm their role to cope with heat stress. The long-term exposure induces alterations limited to 14 genes, and only one annotated gene is upregulated in response to both heat stresses. The decline in transcriptomic response after a long-term exposure indicates that the changes observed in the short-term are likely due to an acclimation response. Therefore, A. antarcticus could be able to cope with increasing temperature over time, including the future conditions imposed by global climate change.