bluuebunny/crossref_metadata_2025_split huggingface dataset:
Letter: sex disparity in prognosis of patients with hepatocellular carcinoma after resection
Authors: Deng Zhu‐Jian , Liu Hao‐Tian , Gong Wen‐Feng , Xiang Bang‐De , Zhong Jian‐Hong 
Published: September 2023

LINKED CONTENTThis article is linked to Rich et al paper. To view these article, visit https://doi.org/10.1111/apt.15917
Letter: synergistic role of gut flora with aspirin to prevent colorectal cancers
Authors: Li Shuling , Peng Fei , Hua Li , Xue Lei 
Published: September 2023

LINKED CONTENTThis article is linked to Prizment et al and papers. To view these articles, visit https://doi.org/10.1111/apt.16013 and https://doi.org/10.1111/apt.16141
Editorial: is age just a number when it comes to treatment of inflammatory bowel disease?
Authors: Ma Christopher , Singh Siddharth , Heatherington Joan , Panaccione Remo 
Published: September 2023

LINKED CONTENTThis article is linked to Asscher et al papers. To view these articles, visit https://doi.org/10.1111/apt.16073 and https://doi.org/10.1111/apt.16106
Editorial: is age just a number when it comes to treatment of inflammatory bowel disease? Authors' reply
Authors: Asscher Vera E. R. , Biemans Vince B. C. , Hoentjen Frank , Maljaars P. W. Jeroen ,   the Dutch Initiative on Crohn and Colitis (ICC)
Published: September 2023

LINKED CONTENTThis article is linked to Asscher et al and Ma et al papers. To view these articles, visit https://doi.org/10.1111/apt.16073 and https://doi.org/10.1111/apt.16098
Pharmacodynamics of tegoprazan and revaprazan after single and multiple oral doses in healthy subjects
Authors: Sunwoo Jung , Ji Sang Chun , Oh Jaeseong , Ban Mu Seong , Nam Ji Yeon , Kim Bongtae , Song Geun Seog , Yu Kyung‐Sang , Jang In‐Jin , Lee SeungHwan 
Published: September 2023

SummaryBackgroundPotassium‐competitive acid blockers (P‐CABs) are emerging as novel treatments for acid‐related disorders including gastroesophageal reflux disease. Tegoprazan and revaprazan are approved P‐CABs in South Korea, but the pharmacodynamics and safety/tolerability of the two drugs have never been compared.AimsTo evaluate the pharmacodynamics and safety/tolerability of tegoprazan and revaprazan after single and multiple oral dosesMethodsA randomised, open‐label, active‐controlled study was conducted in Helicobacter pylori‐negative healthy Korean male subjects. Tegoprazan 50 mg or revaprazan 200 mg was administered orally, once daily for 7 days; 24‐h intragastric pH monitoring and serum gastrin were measured for pharmacodynamic evaluation. Safety parameters including serum microRNA‐122 (miR‐122) level were also collected.ResultsAfter a single dose, the %Time pH ≥4 for tegoprazan was greater than that for revaprazan (54.5% vs 25.1%). After multiple doses, the %Time pH ≥4 for tegoprazan was also greater than that for revaprazan (68.2% vs 25.3%). %Time pH ≥4 during 12 hours at nighttime for tegoprazan was greater than that for revaprazan (71.8% vs 31.9%). The changes in the serum gastrin were not clinically significant for either drug. Despite the slight increases of serum miR‐122 for each drug, tegoprazan and revaprazan were well tolerated considering other safety parameters including AST and ALT levels.ConclusionTegoprazan 50 mg showed stronger gastric acid suppression than revaorazan 200 mg. Both drugs were well tolerated.
Letter: faecal microbiota transplantation for irritable bowel syndrome—which improvements are required? Authors' reply
Authors: Perttu Lahtinen , Jonna Jalanka , Anna Hartikainen , Eero Mattila , Markku Hillilä , Jari Punkkinen , Jari Koskenpato , Veli‐Jukka Anttila , Jyrki Tillonen , Reetta Satokari , Perttu Arkkila 
Published: September 2023

LINKED CONTENTThis article is linked to Lahtinen et al and El‐Salhy et al papers. To view these articles, visit https://doi.org/10.1111/apt.15942 and https://doi.org/10.1111/apt.16112
NUDT15 C415T variant compared with TPMT genotyping in predicting azathioprine‐induced leucopenia: prospective analysis of 1014 inflammatory bowel disease patients in India
Authors: Banerjee Rupa , Ravikanth Vishnubhotla Venkata , Pal Partha , Bale Govardhan , Avanthi Urmila Steffie , Goren Idan , Girish B. Ganesh , Mitnala Sasikala , Reddy D. Nageshwar 
Published: September 2023

SummaryBackgroundRecent studies reported that Nudix Hydrolase 15(NUDT 15) gene variant (C415T) can better predict thiopurine induced leucopenia in Asian patients with inflammatory bowel disease (IBD) than thiopurine S‐methyl transferase (TPMT).AimTo evaluate the role of the NUDT variant compared with TPMT in predicting azathioprine induced leucopenia in Indian IBD patients.MethodsProspectively collected data of consecutive patients treated with azathioprine from a large IBD registry were analysed for side effects, discontinuation time, and initial and maximum dose tolerated. Genotyping of NUDT15 C415T (rs116855232; p.R139C) was carried out retrieving blood samples from bio‐repository employing real time polymerase chain reaction with age and sex‐matched healthy volunteers. The association of NUDT15 C415T with leucopenia (<3 × 109/L) and neutropenia (<1.5 × 109/L) was evaluated. TPMT genotyping was done in patients who developed leucopenia.ResultsAmong 1014 patients (mean age 35.84 ± 12.74 years; 61% males; 54% ulcerative colitis, 44% Crohn's disease and 2% IBD‐unclassified), 79 were excluded due to inadequate blood samples. Of the remaining 935, 81 (9%) developed leucopenia and 70 (7.5%) developed neutropenia. The variant “T” allele [heterozygous (CT) and homozygous (TT) versus wild type (CC)] was associated with a 19‐fold higher odds (OR19.35, 95% CI11.55‐32.42; P < 0.0001) of leucopenia and 21‐fold higher odds of neutropenia (OR21.41, 95% CI12.25‐37.41). There was significant difference in median dose tolerated between CC, CT and TT (1.35, 1.38 and 0.92 mg/kg body weight, respectively) (P = 0.037) and median duration of therapy (18, 15 and 10 months for CC/CT/TT) (P = 0.003). NUDT15 genotype was an independent risk factor for leucopenia (hazard ratio (HR): CT 11.31, 95% CI6.85‐18.03, P < 0.0001 and TT 31.283, 95% CI14.76‐66.30 compared to CC) and neutropenia (HR: CT 13.04, 95% CI7.65‐22.22, P < 0.0001 and TT 43.39, 95% CI20.21‐92.68 compared to CC). The sensitivities for predicting leucopenia and neutropenia by number of mutant NUDT 15 alleles based on additive predictive model were 66.67% and 70% with a receptor operator characteristic curve area under curve value of 0.791 and 0.807, respectively. Among patients with leucopenia, only 6.2% were heterozygous and none were homozygous for TPMT variants.ConclusionNUDT15 variant genotyping appears to be a better predictor for azathioprine‐induced leucopenia in an Indian population than TPMT with high accuracy and can be useful in optimizing azathioprine dosage.
Latent Factor Model for Multivariate Functional Data
Authors: Li Ruonan , Xiao Luo 
Published: September 2023

AbstractFor multivariate functional data, a functional latent factor model is proposed, extending the traditional latent factor model for multivariate data. The proposed model uses unobserved stochastic processes to induce the dependence among the different functions, and thus, for a large number of functions, may provide a more parsimonious and interpretable characterization of the otherwise complex dependencies between the functions. Sufficient conditions are provided to establish the identifiability of the proposed model. The performance of the proposed model is assessed through simulation studies and an application to electroencephalography data.
How do self‐advocates use community development to change attitudes to disability?
Authors: Robinson Sally , Idle Jan , Fisher Karen R. , Reedy Kathleen , Newman Christy , Purcal Christiane , Giuntoli Gianfranco , Byrne Sarah , Nankivell Ruby , Burner Gavin , Touzeau Rebeka , Adam Tim , Armstrong Paige 
Published: September 2023

AbstractBackgroundNegative attitudes remain a major barrier to the equality of people with disability, especially when coupled with the lack of autonomy imposed on many people. This paper analyses how disability self‐advocacy groups seek to change community attitudes and work towards systemic change by mobilising knowledge from their lived experience.MethodsThe paper applies a cycle of praxis community development approach (a cycle of experience, learning and reflection, synthesis and planning, and implementation and review) to conceptualise and analyse their activities. The methods were a desktop document search, focus groups and reflective analysis with members of two self‐advocacy groups.FindingsA synthesised data analysis found that applying the four‐part community development framework was useful to understand the practice and the purpose of work by self‐advocacy groups to change attitudes. The analysis also demonstrates the benefits for advocates and codesigned activities to intentionally apply the cycle of praxis model to guide their future efforts to change attitudes.ConclusionsThe research provides evidence that self‐advocacy groups achieve sustained impacts on attitudes in the community, beyond the direct benefit to their members. Government investment in self‐advocacy has potential to leverage wider system change in attitudes to achieve policy goals for the rights of people with disability. Methodologically, the research also has implications for the benefit of inclusive roles in reflective analysis to understand the lived experience of how practices contribute to system change. The design is an opportunity for inclusive researchers to intentionally incorporate reflective analysis into research processes.
Efficacy and safety of cetagliptin as monotherapy in patients with type 2 diabetes: A randomized, double‐blind, placebo‐controlled phase 3 trial
Authors: Ji Linong , Lu Jinmiao , Gao Leili , Ying Changjiang , Sun Jiao , Han Jie , Zhao Wenhua , Gao Yunming , Wang Kun , Zheng Xin , Xie Daosheng , Ding Juping , Zhao Jiahong , Yu Qiang , Wang Tong 
Published: September 2023

AbstractAimTo assess the efficacy and safety of the dipeptidyl peptidase‐4 inhibitor, cetagliptin, as monotherapy in Chinese patients with type 2 diabetes (T2D) and inadequate glycaemic control.Materials and MethodsIn total, 504 eligible patients with T2D were enrolled and randomized to cetagliptin 50 mg once daily, cetagliptin 100 mg once daily or placebo at a ratio of 2:2:1 for 24 weeks of double‐blind treatment, then all patients received cetagliptin 100 mg once daily for 28 weeks of open‐label treatment. The primary efficacy endpoint was the change in HbA1c level from baseline at week 24.ResultsAfter 24 weeks, HbA1c from baseline was significantly reduced with cetagliptin 50 mg (−1.08%) and cetagliptin 100 mg (−1.07%) compared with placebo (−0.35%). The placebo‐subtracted HbA1c reduction was −0.72% with cetagliptin 50 mg and 100 mg. Patients with a baseline HbA1c of 8.5% or higher had a greater HbA1c reduction with cetagliptin than those patients with a baseline HbA1c of less than 8.5%. Both doses studied led to a significantly higher proportion of patients (42.3% with 100 mg and 45.0% with 50 mg) achieving an HbA1c of less than 7.0% compared with placebo (12.9%). Cetagliptin also significantly lowered fasting plasma glucose and 2‐hour postmeal plasma glucose relative to placebo. The incidence of adverse experiences was similar between cetagliptin and placebo. No drug‐related hypoglycaemia was reported.ConclusionsCetagliptin monotherapy was effective and well tolerated in Chinese patients with T2D who had inadequate glycaemic control on exercise and diet.
Busulfan induces steatosis in HepaRG cells but not in primary human hepatocytes: Possible explanations and implication for the prediction of drug‐induced liver injury
Authors: Allard Julien , Bucher Simon , Ferron Pierre‐Jean , Launay Youenn , Fromenty Bernard 
Published: September 2023

AbstractBackgroundThe antineoplastic drug busulfan can induce different hepatic lesions including cholestasis and sinusoidal obstruction syndrome. However, hepatic steatosis has never been reported in patients.ObjectivesThis study aimed to determine whether busulfan could induce steatosis in primary human hepatocytes (PHH) and differentiated HepaRG cells.MethodsNeutral lipids were determined in PHH and HepaRG cells. Mechanistic investigations were performed in HepaRG cells by measuring metabolic fluxes linked to lipid homeostasis, reduced glutathione (GSH) levels, and expression of genes involved in lipid metabolism and endoplasmic reticulum (ER) stress. Analysis of two previous transcriptomic datasets was carried out.ResultsBusulfan induced lipid accumulation in HepaRG cells but not in six different batches of PHH. In HepaRG cells, busulfan impaired VLDL secretion, increased fatty acid uptake, and induced ER stress. Transcriptomic data analysis and decreased GSH levels suggested that busulfan‐induced steatosis might be linked to the high expression of glutathione S‐transferase (GST) isoenzyme A1, which is responsible for the formation of the hepatotoxic sulfonium cation conjugate. In keeping with this, the GST inhibitor ethacrynic acid and the chemical chaperone tauroursodeoxycholic acid alleviated busulfan‐induced lipid accumulation in HepaRG cells supporting the role of the sulfonium cation conjugate and ER stress in steatosis.ConclusionWhile the HepaRG cell line is an invaluable tool for pharmacotoxicological studies, it might not be always an appropriate model to predict and mechanistically investigate drug‐induced liver injury. Hence, we recommend carrying out toxicological investigations in both HepaRG cells and PHH to avoid drawing wrong conclusions on the potential hepatotoxicity of drugs and other xenobiotics.
Colour‐blind racial attitudes in entry‐level dental hygiene students in Virginia
Authors: Ludwig Emily , Suedbeck Jessica 
Published: September 2023

AbstractObjectiveSubscribing to colour‐blind racial attitudes may contribute to inequities in the delivery of oral care and affect treatment of diverse patients. The purpose of this study was to survey all entry‐level dental hygiene students in one state to determine colour‐blind racial attitudes.MethodsAfter IRB approval, a convenience sample of 220 dental hygiene students in all entry‐level programmes in Virginia were invited to participate in this cross‐sectional study. The Colour‐Blind Racial Attitudes Scale (CoBRAS), an effective, validated measuring instrument, was used to quantify unawareness of contemporary racist ideals. Three subscales (Racial Privilege, Institutional Discrimination and Blatant Racial Issues) were also measured by the survey. Descriptive statistics, separate one‐way between‐subjects ANOVA and independent samples t‐tests were used to analyse the data.ResultsOne‐hundred and sixty (n = 160) dental hygiene students completed the survey. Independent samples t‐tests revealed statistically significant differences when comparing year in programme and programme type. Participants in their second year of dental hygiene education had significantly lower overall CoBRAS scores compared to those in their first year of education (M = 50.76, M = 59.13, respectively; p = 0.004). Participants enrolled in a baccalaureate dental hygiene (B.S.) programme had significantly lower overall CoBRAS scores compared to those enrolled in an associate (A.S.) programme (M = 50.53, M = 59.54, respectively; p = 0.002).ConclusionsParticipants possessed moderate levels of colour‐blindness, suggesting a need for more awareness and training early in dental hygiene education to increase delivery of culturally competent oral healthcare.
Serum vitamin B12, distal symmetrical polyneuropathy and anaemia in type 2 diabetes: the Fremantle Diabetes Study Phase 2
Authors: Davis Timothy M. E. , Chubb Stephen A. P. , Peters Kirsten E. , Davis Wendy A. 
Published: September 2023

AbstractBackgroundThere are limited data relating to the effects of metformin‐associated vitamin B12 deficiency on the risk of distal symmetrical polyneuropathy (DSPN) and megaloblastic anaemia in well‐characterised community‐based cohorts.AimsTo assess inter‐relationships between metformin therapy, vitamin B12 deficiency assessed using serum active B12 concentrations, and DSPN and anaemia in 1492 Fremantle Diabetes Study Phase 2 (FDS2) participants with type 2 diabetes.MethodsPrevalence rates of vitamin B12 deficiency (total <80 pmol/L, active <23 pmol/L) and borderline deficiency (total ≥80 and ≤200 pmol/L, active ≥23 and ≤35 pmol/L) were determined using baseline sera. The relationship between vitamin B12 status and both DSPN and anaemia was assessed using multivariable analyses.ResultsMost FDS2 participants (94.4%) were vitamin B12 replete (total serum concentration >200 pmol/L, active >35 pmol/L), 2.0% were deficient (total <80 pmol/L, active <23 pmol/L) and the remainder (3.6%) borderline. Although metformin treatment increased the odds of deficiency (4.2%, 3.1% borderline) in a dose‐dependent fashion (odds ratio (95% confidence interval) 39.4 (4.90–316) for >2000 mg daily compared with no treatment; P < 0.001), there was no significant association between vitamin B12 status and DSPN, anaemia (haemoglobin ≤130 g/L males, ≤120 g/L females), haemoglobin concentration or mean corpuscular volume (P ≥ 0.147). Metformin increased the likelihood of anaemia, especially at high doses, independent of vitamin B12 deficiency.ConclusionsSince nutritional sources likely attenuate metformin‐associated vitamin B12 malabsorption and its clinical sequelae in developed countries such as Australia, there is no need for routine/opportunistic serum vitamin B12 screening in metformin‐treated patients.
Film as a pedagogical tool for climate change and mental health nursing education
Authors: Abebe Natania , Bailey Elisabeth , Radu Raluca 
Published: September 2023

AbstractThe relationship between climate change and worsening mental health is of increasing concern globally. Climate change is ubiquitous, yet marginalized populations bear a disproportionate burden of the physical and mental health impacts, while youth are more likely to report mental health concerns related to climate change than older generations. Mental health nurses will inevitably see these impacts play out in their practice, thus it is important to explore innovative tools for teaching about and responding to the emotional and psychological impacts of climate change. This perspective paper presents an educational project that utilized film and structured reflection to engage with the intersecting topics of planetary and mental health. The authors created a documentary film that presents the relationship between mental health and climate change as well as an accompanying reflective toolkit. Both the film and toolkit were integrated into an undergraduate course about the health impacts of climate change. This paper explores the relevance of climate change to mental health nursing education and practice, describes the process of creating and integrating the film and toolkit into a course and advances the position that film is an innovative way to engage individuals and communities (such as student or community groups) with the emotional and psychological concerns that arise in response to complex challenges of climate change. More research is needed to better understand the mental health impacts of climate change and to explore novel approaches to education and advocacy about this topic. We hope that sharing our project and experiences will inspire additional discussion and research related to these emerging issues that are of great relevance to mental health nursing.
Inclusive Signs: A Teaching and Learning Toolkit to Generate Inclusive Meta‐Design Concepts
Authors: Rossi Emilio 
Published: September 2023

AbstractThe value introduced by informed teaching practices on Design for Social Inclusion is becoming widely accepted by many Design programmes worldwide, though students frequently struggle to propose novel concepts and design ideas from which to develop inclusive solutions. Both teachers and students often employ stereotyped concepts that ultimately lead them to propose ‘disabling solutions’. This inevitably brings emphasis on the urgency to equip students with original tools through which to design meaningful inclusive artefacts. This article presents ‘Inclusive Signs’, an innovative toolkit for students of Design programmes interested in making innovative solutions that adhere the Social Inclusion's key vision and broader concept. Tests carried out in university contexts with groups of students and designers resulted in an innovative range of inclusive ideas and projects showing the potential to include the toolkit within innovative teaching practices. Therefore, the toolkit easily allows students of Design programmes to get more awareness on how to develop original design processes and ideas closely linked to Social Inclusion.
Differences between migrasome, a ‘new organelle’, and exosome
Authors: Xu Xuebing , Wu Tong , Lin Renjie , Zhu Shengze , Ji Jie , Jin Dandan , Huang Mengxiang , Zheng Wenjie , Ni Wenkai , Jiang Feng , Xuan Shihai , Xiao Mingbing 
Published: September 2023

AbstractThe migrasome is a new organelle discovered by Professor Yu Li in 2015. When cells migrate, the membranous organelles that appear at the end of the retraction fibres are migrasomes. With the migration of cells, the retraction fibres which connect migrasomes and cells finally break. The migrasomes detach from the cell and are released into the extracellular space or directly absorbed by the recipient cell. The cytoplasmic contents are first transported to the migrasome and then released from the cell through the migrasome. This release mechanism, which depends on cell migration, is named ‘migracytosis’. The main components of the migrasome are extracellular vesicles after they leave the cell, which are easy to remind people of the current hot topic of exosomes. Exosomes are extracellular vesicles wrapped by the lipid bimolecular layer. With extensive research, exosomes have solved many disease problems. This review summarizes the differences between migrasomes and exosomes in size, composition, property and function, extraction method and regulation mechanism for generation and release. At the same time, it also prospects for the current hotspot of migrasomes, hoping to provide literature support for further research on the generation and release mechanism of migrasomes and their clinical application in the future.