bluuebunny/crossref_metadata_2025_split huggingface dataset:
Southernmost occurrence of Gobiosoma hemigymnum (Eigenmann & Eigenmann, 1888) on salt marshes of the Bahia Blanca estuary, Argentina: an unusual finding
Authors: Molina Lucas M. , González Dubox M. Cecilia , Lopez Cazorla Andrea 
Published: April 2023

Abstract
Salt marshes do not present favourable conditions for cryptic fish species to inhabit these areas, mainly due to dryness and high temperatures at low tides, and scarce places to hide. Despite the harsh environmental conditions, we report, for the first time, the occurrence of two specimens of the half-naked goby Gobiosoma hemigymnum at high marsh, between oysters and Spartina alteniflora stems. In this paper we report evidence of a possible positive effect of autogenic ecosystem engineer and invasive species, the Pacific oyster (Magallana gigas), over the gobid, Gobiosoma hemigymnum, found 600 km away from its southernmost normal range.
Does learning to play an instrument have an impact on change in attainment from age 11 to 16?
Authors: Baker David , Hallam Susan , Rogers Kevin 
Published: April 2023

AbstractMuch previous international research has demonstrated links between general school attainment and active engagement with music. The research reported here compared the change in examination outcomes in English and mathematics in national examinations at ages 11 and 16 of instrumentalists and non-instrumentalists. Data from 701 pupils showed statistically significant differences in examination outcomes between instrumentalists and non-instrumentalists, which was also related to the duration of learning and the instrument played. Instrumentalists had greater change scores in mathematics, but not English, although instrumentalists of lower socio-economic status showed greater change in both subjects. The implications for music education are discussed.
Self-Validation Theory: Confidence can Increase but also Decrease Performance in Applied Settings
Authors: Briñol Pablo , Petty Richard E. , Moreno Lorena , Gandarillas Beatriz 
Published: April 2023

AbstractThis article presentsself-validation theory(SVT) as a framework predicting when mental contents guide performance. First, we illustrate how confidence can validate people’s thoughts (goals, beliefs, identity) increasing and decreasing performance, depending on what thoughts are validated. This first section reviews examples of validation processes in guiding intellectual performance in academic settings, sport performance in athletes, as well as performance on diverse social tasks. SVT specifies moderating conditions for validation processes to operate. Therefore, in the second section of this review, we identify unique and testable moderators for metacognitive processes demonstrating when and for whom validation processes are more likely to occur. A third section calls for future research identifying new validating variables (e.g., preparation, courage) capable of increasing usage of unexplored thoughts relevant to performance (e.g., expectations). This final section examines new domains for validation (e.g., group performance, cheating in performance), discusses to what extent people can use self-validation strategies deliberatively to improve their performance and addresses when performance can be impaired by invalidation (e.g., due to identity threat).
Operations Eclipse Sequencing in Multipurpose Dam Planning
Authors: Arnold Wyatt , Salazar Jazmin Z. , Carlino Angelo , Giuliani Matteo , Castelletti Andrea 
Published: April 2023

AbstractA resurgence of dam planning and construction is under way in river basins where untapped hydropower potential could meet growing energy demands. Despite calls for more comprehensive evaluation of dam projects, most dams continue to be planned with traditional methods that neglect interdependencies between planning and management and cumulative impacts of multiple new dams. Using the transboundary Zambezi Watercourse as a case study where competing demands for water, energy, and food are increasing, we contribute to a novel dam planning approach that integrates sequencing of planned reservoirs with adaptive operations. While additional hydropower capacity reduces structural energy deficits, operating polices emerge as the main driver of human‐environmental tradeoffs, so much so that single‐objective operating policy selection may lead to erroneous perceptions of tradeoffs across infrastructure options. Furthermore, compared to an operation and sequencing strategy that singularly maximizes hydropower, seeking compromise through operations while constructing dams early improves environmental and irrigation objectives by 50% and 80% with an 8% loss in hydropower. Alternatively, seeking compromise only through delayed dam construction yields modest environmental and irrigation improvements of 6% and 9%, respectively, with a 22% loss in hydropower. The robustness of this result is tested under an ensemble of stochastic streamflow where environmental flow and irrigation deficits are found more sensitive to operations than shifts in water availability. The predominance of operating policies is relevant for improving multi‐objective dam planning in other river basins already fragmented by dams built in the twentieth century.
Geoelectric Characterization of Hyporheic Exchange Flow in the Bedrock‐Lined Streambed of East Fork Poplar Creek, Oak Ridge, Tennessee
Authors: Ikard Scott J. , Carroll Kenneth C. , Rucker Dale F. , Adams Ryan F. , Brooks Scott C. 
Published: April 2023

AbstractA multimethod geoelectric survey was implemented between January and March 2022 along a 220‐m long reach of the bedrock‐lined streambed of East Fork Poplar Creek in Oak Ridge, Tennessee to identify locations of surface‐water and groundwater exchange and characterize the subsurface flow paths that convey water between the stream and flood plain. A waterborne self‐potential (WaSP) survey was completed in January 2022 to measure the electric streaming‐potential field in the stream. Electric resistivity tomography (ERT) was performed in March 2022 on the flood plain adjacent to the WaSP survey reach to map the electric resistivity distribution and characterize the hydrogeology and subsurface flow paths that facilitate surface‐water and groundwater exchange in the bedrock‐lined stream. The combination of WaSP and ERT data support the qualitative interpretation that surface‐water and groundwater exchange likely occurs along fractures in outcropping bedrock and along two fault lines that intersect the limestone creek bed.
Combining Triple‐Moment Ice With Prognostic Liquid Fraction in the P3 Microphysics Scheme: Impacts on a Simulated Squall Line
Authors: Cholette Mélissa , Milbrandt Jason A. , Morrison Hugh , Paquin‐Ricard Danahé , Jacques Dominik 
Published: April 2023

AbstractThe Predicted Particle Properties (P3) bulk microphysics scheme has been recently modified to combine the two major innovations. The triple‐moment approach to represent ice, allowing for a freely evolving spectral dispersion of the size distribution, is combined with the predicted liquid fraction, which enables an explicit representation of mixed‐phase particles. The impacts of this combination are examined in the context of high‐resolution (1‐km horizontal grid spacing) simulations of an observed mid‐latitude squall line using the Global Environmental Multiscale atmospheric model. The simulation of mixed‐phase particles results in a faster squall line propagation speed and stronger cold pool due to greater cooling from the microphysical processes of sublimation, melting and evaporation. There is a reduction in the mass of ice reaching the surface resulting from a decrease in the mean size of melting ice particles aloft with the predicted liquid fraction. Compared to the original double‐moment configuration, triple‐moment P3 configuration results in larger mean ice sizes at the surface. The reflectivity structure is improved with the new version, now with a more pronounced bright band in the melting zone with the predicted liquid fraction.
Linking Stream Chemistry to Subsurface Redox Architecture
Authors: Shaughnessy Andrew R. , Forgeng Michael J. , Wen Tao , Gu Xin , Hemingway Jordon D. , Brantley Susan L. 
Published: April 2023

AbstractAs drinking‐water scarcity grows worldwide, we need to improve predictions of the quantity and quality of our water resources. An overarching problem for model improvement is that we do not know the geological structure of aquifers in sufficient detail. In this work, we demonstrate that mineral‐water reactions imprint structure in the subsurface that impacts the flow and transport of some chemical species. Specifically, pyrite, a ubiquitous mineral, commonly oxidizes and depletes in the upper layers of the weathering profile in most humid watersheds, only remaining at depths of meters. We hypothesize that variations in concentrations (C) of pyrite‐derived sulfate released into rivers as a function of discharge (q) reflect the rate‐limiting step and depth of pyrite‐oxidizing layers. We found that log C − log q behaviors thus differ in small and large watersheds in the Susquehanna River Basin as well as in selected watersheds in the Western United States. Although coal mining changes pyrite oxidation from closed to open system with respect to O2, patterns in stream chemistry as a function of discharge are consistent with deep and shallow pyrite oxidation zones in small and large watersheds respectively. Therefore, understanding the subsurface patterns of mineral reactions and how they affect the architecture of aquifers will elucidate patterns of changing river chemistry and our ability to manage water resources in the future under accelerated land use and climate change.
Clouds Increasingly Influence Arctic Sea Surface Temperatures as CO2 Rises
Authors: Sledd A. , L’Ecuyer T. S. , Kay J. E. , Steele M. 
Published: April 2023

AbstractAs Arctic sea ice retreats during the melt season, the upper ocean warms in response to atmospheric heat fluxes. Overall, clouds reduce these fluxes in summer, but how the radiative impacts of clouds on ocean warming could change as sea ice declines has not been documented. In global climate model simulations with variable CO2, the timing of sea ice retreat strongly influences the amplitude of cloud‐induced summer cooling at the ocean surface. Under pre‐industrial CO2 concentrations, summer clouds have little direct effect on maximum annual sea surface temperatures (SST). When CO2 concentrations increase, sea ice retreats earlier, allowing more solar radiation to warm the ocean. Clouds can counteract this summer warming by reflecting solar radiation back to space. Consequently, clouds explain up to 13% more variability in maximum annual SST under modern‐day CO2 concentrations. Maximum annual SST are three times more sensitive to summer clouds when CO2 concentrations are four times pre‐industrial levels.
Signaling pathways in vascular function and hypertension: molecular mechanisms and therapeutic interventions
Authors: Ma Jun , Li Yanan , Yang Xiangyu , Liu Kai , Zhang Xin , Zuo Xianghao , Ye Runyu , Wang Ziqiong , Shi Rufeng , Meng Qingtao , Chen Xiaoping 
Published: April 2023

AbstractHypertension is a global public health issue and the leading cause of premature death in humans. Despite more than a century of research, hypertension remains difficult to cure due to its complex mechanisms involving multiple interactive factors and our limited understanding of it. Hypertension is a condition that is named after its clinical features. Vascular function is a factor that affects blood pressure directly, and it is a main strategy for clinically controlling BP to regulate constriction/relaxation function of blood vessels. Vascular elasticity, caliber, and reactivity are all characteristic indicators reflecting vascular function. Blood vessels are composed of three distinct layers, out of which the endothelial cells in intima and the smooth muscle cells in media are the main performers of vascular function. The alterations in signaling pathways in these cells are the key molecular mechanisms underlying vascular dysfunction and hypertension development. In this manuscript, we will comprehensively review the signaling pathways involved in vascular function regulation and hypertension progression, including calcium pathway, NO-NOsGC-cGMP pathway, various vascular remodeling pathways and some important upstream pathways such as renin-angiotensin-aldosterone system, oxidative stress-related signaling pathway, immunity/inflammation pathway, etc. Meanwhile, we will also summarize the treatment methods of hypertension that targets vascular function regulation and discuss the possibility of these signaling pathways being applied to clinical work.
A tissue specific-infection mouse model of SARS-CoV-2
Authors: Yang Bo , Liu Chao , Ju Xiaohui , Wu Bingbing , Wang Zhuangfei , Dong Fucheng , Yu Yanying , Hou Xiaohui , Fang Min , Gao Fei , Guo Xuejiang , Gui Yaoting , Ding Qiang , Li Wei 
Published: April 2023

AbstractAnimal models play crucial roles in the rapid development of vaccines/drugs for the prevention and therapy of COVID-19, but current models have some deficits when studying the pathogenesis of SARS-CoV-2 on some special tissues or organs. Here, we generated a human ACE2 and SARS-CoV-2 NF/F knockin mouse line that constitutively expresses human ACE2 and specifically expresses SARS-CoV-2 N gene induced by Cre-recombinase. By crossing with Cre transgenic lines allowing for lung-specific and constitutive expression, we generated lung-specific (Sftpc-hACE2-NF/F) and constitutive SARS-CoV-2 N (EIIa-hACE2-NF/F) expressing mice. Upon intranasal infection with a SARS-CoV-2 GFP/ΔN strain which can only replicate in SARS-CoV-2 N expressed cells, we demonstrated that both the Sftpc-hACE2-NF/F and EIIa-hACE2-NF/F mice support viral replication. Consistent with our design, viral replication was limited to the lung tissues in Sftpc-hACE2-NF/F mice, while the EIIa-hACE2-NF/F mice developed infections in multiple tissues. Furthermore, our model supports different SARS-CoV-2 variants infection, and it can be successfully used to evaluate the effects of therapeutic monoclonal antibodies (Ab1F11) and antiviral drugs (Molnupiravir). Finally, to test the effect of SARS-CoV-2 infection on male reproduction, we generated Sertoli cell-specific SARS-CoV-2 N expressed mice by crossing with AMH-Cre transgenic line. We found that SARS-CoV-2 GFP/ΔN strain could infect Sertoli cells, led to spermatogenic defects due to the destruction of blood-testis barrier. Overall, combining with different tissue-specific Cre transgenic lines, the human ACE2 and SARS-CoV-2 NF/F line enables us to evaluate antivirals in vivo and study the pathogenesis of SARS-CoV-2 on some special tissues or organs.
Integrated transcriptome landscape of ALS identifies genome instability linked to TDP-43 pathology
Authors: Ziff Oliver J. , Neeves Jacob , Mitchell Jamie , Tyzack Giulia , Martinez-Ruiz Carlos , Luisier Raphaelle , Chakrabarti Anob M. , McGranahan Nicholas , Litchfield Kevin , Boulton Simon J. , Al-Chalabi Ammar , Kelly Gavin , Humphrey Jack , Patani Rickie 
Published: April 2023

AbstractAmyotrophic Lateral Sclerosis (ALS) causes motor neuron degeneration, with 97% of cases exhibiting TDP-43 proteinopathy. Elucidating pathomechanisms has been hampered by disease heterogeneity and difficulties accessing motor neurons. Human induced pluripotent stem cell-derived motor neurons (iPSMNs) offer a solution; however, studies have typically been limited to underpowered cohorts. Here, we present a comprehensive compendium of 429 iPSMNs from 15 datasets, and 271 post-mortem spinal cord samples. Using reproducible bioinformatic workflows, we identify robust upregulation of p53 signalling in ALS in both iPSMNs and post-mortem spinal cord. p53 activation is greatest withC9orf72repeat expansions but is weakest with SOD1 and FUS mutations. TDP-43 depletion potentiates p53 activation in both post-mortem neuronal nuclei and cell culture, thereby functionally linking p53 activation with TDP-43 depletion. ALS iPSMNs and post-mortem tissue display enrichment of splicing alterations, somatic mutations, and gene fusions, possibly contributing to the DNA damage response.
Hippocampal sharp wave ripples underlie stress susceptibility in male mice
Authors: Kuga Nahoko , Nakayama Ryota , Morikawa Shota , Yagishita Haruya , Konno Daichi , Shiozaki Hiromi , Honjoya Natsumi , Ikegaya Yuji , Sasaki Takuya 
Published: April 2023

AbstractThe ventral hippocampus (vHC) is a core brain region for emotional memory. Here, we examined how the vHC regulates stress susceptibility from the level of gene expression to neuronal population dynamics in male mice. Transcriptome analysis of samples from stress-naïve mice revealed that intrinsic calbindin (Calb1) expression in the vHC is associated with susceptibility to social defeat stress. Mice with Calb1 gene knockdown in the vHC exhibited increased stress resilience and failed to show the increase in the poststress ventral hippocampal sharp wave ripple (SWR) rate. Poststress vHC SWRs triggered synchronous reactivation of stress memory-encoding neuronal ensembles and facilitated information transfer to the amygdala. Suppression of poststress vHC SWRs by real-time feedback stimulation or walking prevented social behavior deficits. Taken together, our results demonstrate that internal reactivation of memories of negative stressful episodes supported by ventral hippocampal SWRs serves as a crucial neurophysiological substrate for determining stress susceptibility.
Bird tolerance to humans in open tropical ecosystems
Authors: Mikula Peter , Tomášek Oldřich , Romportl Dušan , Aikins Timothy K. , Avendaño Jorge E. , Braimoh-Azaki Bukola D. A. , Chaskda Adams , Cresswell Will , Cunningham Susan J. , Dale Svein , Favoretto Gabriela R. , Floyd Kelvin S. , Glover Hayley , Grim Tomáš , Henry Dominic A. W. , Holmern Tomas , Hromada Martin , Iwajomo Soladoye B. , Lilleyman Amanda , Magige Flora J. , Martin Rowan O. , de A. Maximiano Marina F. , Nana Eric D. , Ncube Emmanuel , Ndaimani Henry , Nelson Emma , van Niekerk Johann H. , Pienaar Carina , Piratelli Augusto J. , Pistorius Penny , Radkovic Anna , Reynolds Chevonne , Røskaft Eivin , Shanungu Griffin K. , Siqueira Paulo R. , Tarakini Tawanda , Tejeiro-Mahecha Nattaly , Thompson Michelle L. , Wamiti Wanyoike , Wilson Mark , Tye Donovan R. C. , Tye Nicholas D. , Vehtari Aki , Tryjanowski Piotr , Weston Michael A. , Blumstein Daniel T. , Albrecht Tomáš 
Published: April 2023

AbstractAnimal tolerance towards humans can be a key factor facilitating wildlife–human coexistence, yet traits predicting its direction and magnitude across tropical animals are poorly known. Using 10,249 observations for 842 bird species inhabiting open tropical ecosystems in Africa, South America, and Australia, we find that avian tolerance towards humans was lower (i.e., escape distance was longer) in rural rather than urban populations and in populations exposed to lower human disturbance (measured as human footprint index). In addition, larger species and species with larger clutches and enhanced flight ability are less tolerant to human approaches and escape distances increase when birds were approached during the wet season compared to the dry season and from longer starting distances. Identification of key factors affecting animal tolerance towards humans across large spatial and taxonomic scales may help us to better understand and predict the patterns of species distributions in the Anthropocene.
Copper-catalyzed asymmetric C(sp2)–H arylation for the synthesis of P- and axially chiral phosphorus compounds
Authors: Yan Shao-Bai , Wang Rui , Li Zha-Gen , Li An-Na , Wang Chuanyong , Duan Wei-Liang 
Published: April 2023

AbstractTransition metal-catalyzed C–H bond functionalization is an important method in organic synthesis, but the development of methods that are lower cost and have a less environmental impact is desirable. Here, a Cu-catalyzed asymmetric C(sp2)–H arylation is reported. With diaryliodonium salts as arylating reagents, a range of ortho-arylated P-chiral phosphonic diamides were obtained in moderate to excellent yields with high enantioselectivities (up to 92% ee). Meanwhile, enantioselective C-3 arylation of diarylphosphine oxide indoles was also realized under similar conditions to construct axial chirality.
Exploiting nonaqueous self-stratified electrolyte systems toward large-scale energy storage
Authors: Wang Zhenkang , Ji Haoqing , Zhou Jinqiu , Zheng Yiwei , Liu Jie , Qian Tao , Yan Chenglin 
Published: April 2023

AbstractBiphasic self-stratified batteries (BSBs) provide a new direction in battery philosophy for large-scale energy storage, which successfully reduces the cost and simplifies the architecture of redox flow batteries. However, current aqueous BSBs have intrinsic limits on the selection range of electrode materials and energy density due to the narrow electrochemical window of water. Thus, herein, we develop nonaqueous BSBs based on Li-S chemistry, which deliver an almost quadruple increase in energy density of 88.5 Wh L−1 as compared with the existing aqueous BSBs systems. In situ spectral characterization and molecular dynamics simulations jointly elucidate that while ensuring the mass transfer of Li+, the positive redox species are strictly confined to the bottom-phase electrolyte. This proof-of-concept of Li-S BSBs pushes the energy densities of BSBs and provides an idea to realize massive-scale energy storage with large capacitance.
A non-Newtonian fluid quasi-solid electrolyte designed for long life and high safety Li-O2 batteries
Authors: Zheng Guangli , Yan Tong , Hong Yifeng , Zhang Xiaona , Wu Jianying , Liang Zhenxing , Cui Zhiming , Du Li , Song Huiyu 
Published: April 2023

AbstractThe Li dendrite growth and the liquid electrolyte volatilization under semi-open architecture are intrinsic issues for Li-O2 battery. In this work, we propose a non-Newtonian fluid quasi-solid electrolyte (NNFQSE) SiO2-SO3Li/PVDF-HFP, which has both shear-thinning and shear-thickening properties. The component interactions among the sulfonated silica nanoparticles, liquid electrolyte, and polymer network are beneficial for decent Li+ conductivity and high liquid electrolyte retention without volatilization. Furthermore, NNFQSE exhibits shear-thinning property to eliminate the stress of dendrite growth during repeated cycling. Meanwhile, when the force suddenly increases, such as a high current rate, the NNFQSE may dynamically turn shear-thickening to respond and mechanically stiffen to inhibit the lithium dendrite penetration. By coupling with the NNFQSE, the lithium symmetrical battery can run over 2000 h under 1 mA cm−2 at room temperature, and the quasi-solid Li-O2 battery actualizes long life above 5000 h at 100 mA g−1.
Universal structures for adaptation in biochemical reaction networks
Authors: Araujo Robyn P. , Liotta Lance A. 
Published: April 2023

AbstractAt the molecular level, the evolution of life is driven by the generation and diversification of adaptation mechanisms. A universal description of adaptation-capable chemical reaction network (CRN) structures has remained elusive until now, since currently-known criteria for adaptation apply only to a tiny subset of possible CRNs. Here we identify the definitive structural requirements that characterize all adaptation-capable collections of interacting molecules, however large or complex. We show that these network structures implement a form of integral control in which multiple independent integrals can collaborate to confer the capacity for adaptation on specific molecules. Using an algebraic algorithm informed by these findings, we demonstrate the existence of embedded integrals in a variety of biologically important CRNs that have eluded previous methods, and for which adaptation has been observed experimentally. This definitive picture of biological adaptation at the level of intermolecular interactions represents a blueprint for adaptation-capable signaling networks across all domains of life, and for the design of synthetic biosystems.