bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antimicrobial screening involving Helicobacter pylori of nano‐therapeutic compounds based on the amoxicillin antibiotic drug
Authors: Hassan Safaa S. , Nader Madonna , Nagy Maria , Mohamed Mennatallah , Nader Mennatulla , Zakaria Mina , Mohamed Nada , Waleed Rawan , Rashidi Fatma B. 
Published: July 2023

AbstractNano‐structure Cu(II) complex [Cu(AMAB)2]Cl2 with Schiff base (AMAB) derived from the condensation between 4‐(dimethylamino)benzaldehyde and amoxicillin trihydrate was prepared. (AMAB) Schiff base and its Cu(II) complex were identified and confirmed by different physicochemical techniques. The Schiff base (AMAB) was coordinated to copper ion through carbonyl oxygen and imine nitrogen donor sites. X‐ray powder diffraction shows a cubic crystal system of the Cu(II) complex. The density functional theory was used to optimize the structure geometries of the investigated compounds. The molecular docking of the active amino acids of the investigated proteins' interactions with the tested compounds was evaluated. The bactericidal or bacteriostatic effect of the compounds was screened against some bacterial strains. The activity of Cu‐chelate against Gram‐negative bacteria was mainly more effective than its (AMAB) ligand and vice versa in the case of Gram‐positive bacteria. The biological activity of the prepared compounds with biomolecules calf thymus DNA (CT‐DNA) was determined by electronic absorption spectra and DNA gel electrophoresis technique. All studies revealed that the Cu‐chelate derivative exhibited better binding affinity to both CT‐DNA than the AMAB and amoxicillin itself. The anti‐inflammatory effect of the designed compounds was determined by testing their protein denaturation inhibitory activity spectrophotometrically. All obtained data supported that the designed nano‐Cu(II) complex with Schiff base (AMAB) is a potent bactericide against H. pylori, and exhibits anti‐inflammatory activity. The dual inhibition effects of the designed compound represent a modern therapeutic approach with extended spectrum of action. Therefore, it can act as good drug target in antimicrobial and anti‐inflammtory therapies. Finally, H. pylori resistance to amoxicillin is absent or rare in many countries, thus amoxicillin nanoparticles may be beneficial for countries where amoxicillin resistance is reported.
Migration and leaching behaviour of Bisphenol A from polyethylene terephthalate water bottles under different storage conditions
Authors: Mârşolea Adriana C. , Chiriac Florentina L. , Orbeci Cristina , Bobiricǎ Liliana , Bobiricǎ Constantin 
Published: July 2023

SummaryThe release of bisphenol A (BPA) from polyethylene terephthalate (PET) bottles in non‐carbonated water was investigated in this work through migration and leaching tests. Several types of PET bottles approved and used by several Romanian non‐carbonated mineral water brands were tested in this work. It was highlighted that both the storage temperature and the storage time of bottled water in PET bottles influence the degree of PBA release. Thus, increasing the temperature and storage time favours the release of BPA from PET. The higher the storage temperature, the higher is the diffusivity of BPA. The degree of BPA release is also closely related to the brand of PET. This could be related to the degree of contamination of the raw material in the manufacturing process of PET bottles or during their recycling. The physico‐chemical characteristics and stability of PET bottles in different environmental conditions can also influence the release of BPA from them. The leaching tests confirmed the potential for BPA contamination of long‐term non‐carbonated water bottled in PET bottles.
Enhancing flavour with non‐Saccharomyces during vinegar alcoholisation: a mechanism study
Authors: Wang Fengjun , Zhu Ling , Hadiatullah Hadiatullah , Li Zhaofei , He Jing , Yao Yunping , Zhao Guozhong 
Published: July 2023

SummaryThe effects of mixed fermentation of non‐Saccharomyces (Pichia fabianii, Kluyveromyces thermotolerans, and Saccharomycopsis fibuligera) with Saccharomyces cerevisiae on the physicochemical indexes and flavour of rice vinegar fermentation were studied. The mixed fermentation increased the activity of β‐glucosidase and esterification enzyme. The β‐glucosidase activity of P. fabianii was 1.6 times higher than that of S. cerevisiae alone, and the esterification enzyme activity was increased by about four times. Compared with the single fermentation of S. cerevisiae, the mixed fermentation of P. fabianii and S. cerevisiae increased the type and content of aromatic esters and produced ethyl acetate and phenethyl acetate. The mixed fermentation of K. thermotolerans and S. cerevisiae made an outstanding contribution to produce higher alcohols. Among them, the content of isobutanol and phenylethanol increased by nearly ten times; the content of isoamylol increased by more than eight times. S. fibuligera provides a unique flavour of phenols because of 2‐methoxy‐4‐ethylphenol and 2‐methoxy‐4‐ethylphenol.
How well may the direct linguistic declarations substitute AHP in defining accurate criteria weights?
Authors: Wachowicz Tomasz , Roszkowska Ewa 
Published: July 2023

AbstractThis paper investigates the problem of defining the weights in multiple criteria decision‐making analysis. In particular, we analyze if weights determined by decision makers (DMs) using the classic analytic hierarchy process (AHP) approach can be reproduced using more straightforward direct linguistic weights declarations (DLWD). Using the dataset from an online decision‐making experiment, we analyze the concordance of systems of weights obtained by DMs from AHP and DLWD. Applying optimization models, we check if the discrepancies between the AHP and DLWD weights result from (a) inefficiently declared mixes of linguistic labels in the symmetrically distributed scale or (b) using the unbalanced linguistic term set by DMs. The main findings are that the systems of weights obtained by DMs in the experiment from AHP and DLWD differ significantly. While using DLWD, most DMs defined criteria ranks contradictory to those resulting from AHP. They avoided extensive use of extreme labels from the 7‐point scale. The optimization results show that DLWD based on the symmetric scale might produce the most similar weights to AHP if a full range of linguistic terms was used, not only the intermediate ones. The differences in DMs’ cognitive profiles seem not to affect the results.
The pediatric provider communication skills assessment scale
Authors: Boztepe Handan , Çınar Özbay Sevil , Akçam Aysun , Kanbay Yalçın 
Published: July 2023

AbstractProblemBuilding rapport and trust between healthcare professional and patient/parents would improve satisfaction of patient/parents. The purpose of this study was to develop “The Pediatric Provider Communication Skills Assessment Scale” in this study.MethodsA trial form, with linguistic and psychometric validation and consisting of 44 statements, was administered to a sample of 325 individuals. Data were collected between January 20 and October 22, 2021. The validity of the scale was concluded after examining its construct validity and internal validity. “Exploratory factor analysis” was used for determining construct validity, and “comparison of lower‐upper groups” for internal validity. “Cronbach's α reliability coefficient” and “split half test consistency coefficient” were calculated for testing the reliability of the scale.FindingsThe Pediatric Provider Communication Skills Assessment Scale that we developed consists of one dimension and 20 items, and the variance it can explain was calculated as 62.3%. The Cronbach α reliability coefficient of the scale was calculated as 0.90, indicating high reliability.ConclusionsAccording to the findings, “The Pediatric Provider Communication Skills Assessment Scale” is a scale with features that can measure in a valid and reliable way, with high variance and a low number of items. The study aims to develop the “The Pediatric Provider Communication Skills Assessment Scale,” and present it to the literature as a validated and reliable new objective measurement tool. This study will enable us to understand more about the complex communication processes involved in pediatric care and how these may influence care delivery.
Dynamics of quality change in process of shiitake mushroom (Lentinus edodes) cooking
Authors: Liu Yingying , Meng Yijun , Dang Yuli , Guo Shuihuan , Qu Shanshan , Li Jiayin , Li Yu 
Published: July 2023

AbstractTo better predict quality changes during food heating, a kinetic approach was used to determine and analyze the reaction kinetics of changes in ripening quality factors (color and hardness). The moisture content as a superheated quality factor was superheated to improve the quality of shiitake dishes during the cooking of shiitake mushroom. The results showed that the changes in L*, a*, hardness, and moisture content of the shiitake mushroom followed the first‐order reaction kinetics model, and the changes in h* and △E of the shiitake mushroom followed the zero‐order reaction kinetics model as the temperature increased during cooking. The z values of L*，a*，h*, and △E were 56.22,42.19,45.02 and 47.90°C and the Ea values were 34.20, 34.78, 41.33, and 26.43 kJ/mol, respectively. The z value for hardness was 49.67°C and Ea value was 25.92 kJ/mol. The z value for moisture content was 67.31°C and Ea value was 37.32 kJ/mol, which was greater than the z values of color and hardness. The z values of mature quality factors were less than the z value of overheating quality factor, which was in accordance with the requirement of cooking operation optimization. Our results proved that there was room for optimization of shiitake mushroom in the cooking process.Practical applicationThis study investigated the kinetics of quality changes of shiitake mushroom during cooking. In practical application, it could better predict the quality changes of shiitake mushroom during heating, determine the optimal cooking time by monitoring the changes of ripeness factor and overheating factor during cooking, facilitate food enterprises to design heat supply more scientifically, and provide basic data to promote the industrial production of shiitake pre‐prepared dishes.
Obesity during preclinical Alzheimer's disease development exacerbates brain metabolic decline
Authors: Anderson Thea , Sharma Sumeet , Kelberman Michael A. , Ware Christopher , Guo Nanxi , Qin Zhaohui , Weinshenker David , Parent Marise B. 
Published: July 2023

AbstractAlzheimer's disease (AD) is the most common form of dementia. Obesity in middle age increases AD risk and severity, which is alarming given that obesity prevalence peaks at middle age and obesity rates are accelerating worldwide. Midlife, but not late‐life obesity increases AD risk, suggesting that this interaction is specific to preclinical AD. AD pathology begins in middle age, with accumulation of amyloid beta (Aβ), hyperphosphorylated tau, metabolic decline, and neuroinflammation occurring decades before cognitive symptoms appear. We used a transcriptomic discovery approach in young adult (6.5 months old) male and female TgF344‐AD rats that overexpress mutant human amyloid precursor protein and presenilin‐1 and wild‐type (WT) controls to determine whether inducing obesity with a high‐fat/high‐sugar “Western” diet during preclinical AD increases brain metabolic dysfunction in dorsal hippocampus (dHC), a brain region vulnerable to the effects of obesity and early AD. Analyses of dHC gene expression data showed dysregulated mitochondrial and neurotransmission pathways, and up‐regulated genes involved in cholesterol synthesis. Western diet amplified the number of genes that were different between AD and WT rats and added pathways involved in noradrenergic signaling, dysregulated inhibition of cholesterol synthesis, and decreased intracellular lipid transporters. Importantly, the Western diet impaired dHC‐dependent spatial working memory in AD but not WT rats, confirming that the dietary intervention accelerated cognitive decline. To examine later consequences of early transcriptional dysregulation, we measured dHC monoamine levels in older (13 months old) AD and WT rats of both sexes after long‐term chow or Western diet consumption. Norepinephrine (NE) abundance was significantly decreased in AD rats, NE turnover was increased, and the Western diet attenuated the AD‐induced increases in turnover. Collectively, these findings indicate obesity during prodromal AD impairs memory, potentiates AD‐induced metabolic decline likely leading to an overproduction of cholesterol, and interferes with compensatory increases in NE transmission.image
Is maternal serum endocan level a novel marker in gestational diabetes mellitus?
Authors: Yıldız Elif , Ketenci Gencer Fatma , Timur Burcu , Laleli Koc Bergen , Timur Hakan 
Published: July 2023

AbstractAimTo determine whether there was a significant difference between serum endocan levels of pregnant women with and without gestational diabetes mellitus (GDM).MethodsA total of 90 pregnant women, 45 with gestational diabetes and 45 healthy pregnant women, between 24 and 28 gestational weeks, were included in this prospective case–control study. The pregnant women were screened for gestational diabetes using a two‐step protocol. Serum endocan levels were measured using a commercially available enzyme‐linked immunosorbent assay (ELISA) kit. A p‐value of <0.05 was considered statistically significant.ResultsSerum endocan level was significantly higher in the GDM group than in healthy controls (168.46 ± 160.6 vs. 105.66 ± 26.52 pg/mL, respectively; p < 0.001). Serum endocan concentrations were positively correlated with the results of 50 g oral glucose challenge test (GCT) (p < 0.001). Receiver operating characteristic curve analysis showed that endocan with a cut‐off point of 133.9 ng/dL indicated women with GDM with a sensitivity of 55.6% and specificity of 88.9% (area under the curve [AUC]: 0.737, 95% CI: 0.634–0.824). The overall differential performance of endocan according to the GDM groups was determined as 73.7% (p < 0.001). Maternal serum endocan level was positively correlated with fasting glucose, postprandial glucose, and glycated hemoglobin (HbA1c) (p < 0.001).ConclusionsElevated endocan levels in gestational diabetes were correlated with fasting glucose, postprandial glucose, HbA1c, and oral glucose tolerance test (OGTT) results. Despite the low sensitivity of 55.6% and the high specificity of 88.9%, we found a high differential performance rate indicating that serum endocan levels were important for the pathophysiology of GDM and should be investigated for the possibility of being a novel marker in larger populations.
Novel technique of stent placement via gateway balloon in intracranial atherosclerosis‐associated large vessel occlusion
Authors: Memon Muhammad Zeeshan , Ezzeldin Mohamad , Biswas Arundhati , Ahmad Rowaid , Nisar Taha , Singla Amit , Muhammad Nazar , Shaltoni Hashem , Kan Peter , Zaidat Osama O. , Khandelwal Priyank 
Published: July 2023

AbstractBackground and PurposeNeuroform Atlas stent can be deployed directly via gateway balloon for angioplasty and stent placement without the need for exchange maneuver required for Wingspan stent use. We present our initial experience of this strategy in intracranial atherosclerosis‐associated large vessel occlusions.MethodsPatients were identified through mechanical thrombectomy (MT) database from January 2020 to June 2022 at our institutions. Due to reocclusion or impending occlusion, rescue angioplasty with stent placement was performed after initial standard MT. Primary outcomes were good angiographic recanalization with modified thrombolysis in cerebral infarction (mTICI) score of 2b‐3, rate of intracranial hemorrhage (ICH), and favorable functional outcome at 3 months, that is, modified Rankin Scale (mRS) score of 0‐3.ResultsWe identified 22 patients treated using this technique. Among those, 11 were females with their average age at 66 years (range: 52‐85). Initial median National Institute of Health Stroke Scale score was 11 (range: 5‐30) and all patients received loading doses of aspirin and P2Y₁₂ inhibitor. After performing submaximal angioplasty and Neuroform Atlas stent deployment through the gateway balloon, we achieved final mTICI of 2b‐3 in 20 (90%) patients. One patient had ICH post‐op that was asymptomatic. Eight (36%) patients had mRS of 0‐3 at 90 days.ConclusionOur preliminary experience suggests possible safety and feasibility of deploying Neuroform Atlas stent through a compatible Gateway balloon microcatheter without the need for ICH‐associated microcatheter exchange. Further studies with long‐term clinical and angiographic follow‐up are warranted to corroborate our initial findings.
Materials and manufacturing techniques for occlusal splints: A literature review
Authors: Nassif Maryse , Haddad Camille , Habli Lara , Zoghby Amine 
Published: July 2023

SUMMARYObjectiveTo review the materials and fabrications methods of occlusal splints with their advantages and shortcomings and to clarify the indications for each.BackgroundTemporomandibular joint disorders (TMDs) encompass a range of conditions affecting the masticatory system. Occlusal splints are currently recognised as a viable option for the management of TMDs when they are adopted in conjunction with additional approaches varying from conservative procedures (counselling, biofeedback, physical therapy, pharmacotherapy) to irreversible and less conservative ones (occlusal adjustments, orthodontics, arthroscopy and surgery). These splints can vary in design, function and material. The components used to fabricate the splints must withstand occlusal forces, be aesthetically pleasing, comfortable and minimally interfering with function and phonetics. Traditional methods for fabricating splints include sprinkle‐on, thermoforming and lost wax techniques. However, with the advancement of CAD/CAM technology, additive (3D printing) and subtractive (milling) manufacturing methods expand the range of possibilities by introducing novel solutions for elaborating splints.MethodsAn electronic search was conducted on PubMed using the following keywords: “occlusal splint”, “guard and “materials”, and “manufacturing.” Thirteen in vitro publications were screened and they consisted of four clinical studies, nine reviews (three of them were systematic reviews), and five case reports.ConclusionThe choice of material is crucial for the success of splint therapy. Factors such as biocompatibility, ease of fabrication, adjustability, cost and patient preference should be considered. Newer materials and techniques are emerging because of advancements in material science and manufacturing techniques. However, it should be noted that most of the evidence is based on in vitro studies with different methodologies, limiting their validity in daily practice.
Effect of a specially formulated diet on progression of heart enlargement in dogs with subclinical degenerative mitral valve disease
Authors: Oyama Mark A. , Scansen Brian A. , Boswood Adrian , Goldfeder Guilherme , Rosenthal Steven , Cober Richard , LaFauci Kendra , Friese Ryan C. , Gomes Márcia , Chang Yu‐Mei Ruby , Li Qinghong 
Published: July 2023

AbstractBackgroundPrevious studies in dogs with degenerative mitral valve disease (DMVD) have identified altered myocardial energy metabolism and oxidation, which might contribute to cardiac hypertrophy. Diets rich in medium chain fatty acids and antioxidants are a potential means of treatment. A previous clinical study found significantly smaller left atrial diameter (LAD) and left atrium‐to‐aorta diameter ratio (LA : Ao) in dogs with subclinical DMVD fed a specially formulated diet vs control diet for 6 months.Hypothesis/ObjectivesA specially formulated diet will slow or arrest left heart enlargement in dogs with subclinical DMVD over 365 days.AnimalsOne hundred twenty‐seven dogs with unmedicated subclinical DMVD; 101 dogs in the per protocol cohort.MethodsRandomized double‐blinded controlled multicenter clinical trial.ResultsThe study's primary composite outcome measure was the sum of percentage change in LAD and left ventricular internal dimension at end‐diastole (LVIDd) at day 365. In the per protocol cohort, the outcome measure increased by 8.0% (95% confidence interval [CI], 2.9%‐13.1%) in dogs receiving the test diet vs 8.8% (95% CI, 5.1%‐12.5%) in dogs receiving control diet (P = .79). Neither component of the primary outcome measure was significantly different between groups (LAD, P = .65; LVIDd, P = .92). No difference was found in mitral valve E wave velocity (P = .36) or the proportion of dogs withdrawn from the study because of worsening DMVD and heart enlargement (P = .41).Conclusions and Clinical ImportanceFeeding a specially formulated diet for 365 days was not associated with a significantly different rate of change of left heart size in dogs with subclinical DMVD as compared to control.
Mice population dynamics and structure over time and space after wildfires
Authors: Puig‐Gironès R. , Pons P. 
Published: July 2023

AbstractRodents respond quickly to changes in habitat structure after wildfires. They constitute important prey items for vertebrate predators and influence vegetation structure and regeneration. Assessing the population dynamics of rodents in burnt areas, whether individuals originate from in situ survival or from ex situ immigration, is therefore a key question in understanding the recovery of trophic networks after disturbance. This study aimed to identify the recovery strategies of rodent populations in recently burnt forests in the Mediterranean basin using body condition, reproductive output, sex ratios, and distance covered by wood mice and Algerian mice. Sampling stations were set up at increasing distances from the perimeter of recently burnt areas. Rodents were captured using Sherman traps and measured. Wood mice and Algerian mice lived syntopically within the recently burnt areas studied, the former species being more abundant and the second one selecting drier areas. Results indicated that time since fire, shrub cover, and distance to the perimeter of the burnt area influenced wood mice and Algerian mice population structures. Adult female wood mice mainly remained close to the burnt area perimeter, due to this species' matriarchal structure, while juvenile males dispersed farther into the burnt area. Adult females were also recaptured more frequently than other age and sex categories over time, whereas males covered greater distances. These findings suggest that the recovery strategy of these widespread Mediterranean rodents is mainly driven by ex situ immigration from unburnt areas. These results will be useful for post‐fire management decisions such as non‐intervention, salvage logging or the conservation of open areas, given that mice are a fundamental component of the ecosystem. Results also suggest that management should focus on maintaining good connectivity between burnt and adjacent unburnt areas to support mice populations and facilitate other longer‐term conservation benefits.