bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relationships between food insecurity, physical activity, detachment from studies, and students' well‐being: A prospective study
Authors: Isoard‐Gautheur Sandrine , Ginoux Clément , Petit Romain , Clavier Viviane , Dias Dulce , Sarrazin Philippe , Couturier Karine 
Published: March 2023

ObjectiveResearch on students' well‐being has shown that studies may have an impact on well‐being. However, this relationship is complex and involves many other parameters (e.g., food security and physical activity). Therefore, the objective of the present study was to investigate the relationships between food insecurity (FI), physical activity (PA), and detachment from studies on the one hand, and student well‐being, on the other.MethodA total of 4410 students (mean age = 21.55, 65 192% female) answered an online survey measuring FI, PA, detachment from studies, anxiety, burnout, depression, and satisfaction with life.ResultsA structural equation model (χ [18] = 585.739, RMSEA = 0.095, 90% CI [0.089; 0.102], comparative fit index [CFI]  = 0.92, NNFI = 0.921) indicated that FI negatively predicted, and that detachment from studies and PA positively predicted, the latent variable of well‐being.DiscussionThe results of the present study highlight that students' well‐being is partly determined by FI, detachment from studies, and PA. Therefore, this study highlights the importance of looking at both the diets of students, as well as the activities and experiences they have outside their studies to gain a better understanding of the factors influencing student well‐being and the action leverages to promote it.
Political support through representation by the government. Evidence from Dutch panel data
Authors: Erhardt Julian 
Published: March 2023

AbstractResearch on political support demonstrates that satisfaction with democracy is higher among electoral winners than losers, and that it is higher for citizens who are ideologically more congruent with the government. In this paper, I analyze how support for the political system is affected by representation by the government. Expanding on previous studies, I leverage long‐run panel data from the Dutch LISS panel spanning over several electoral cycles. Drawing on various measures that go beyond the distinction between election winners and losers and also measure how close citizens are to the government coalition as a whole, I show that being well represented by the government has a wide‐ranging positive relationship with satisfaction with democracy, external efficacy and trust in political institutions. While this relationship is mostly short‐run, political support can decline substantially if non‐representation persists in the long‐run. This highlights the relevance of long‐run panel data for studying the consequences of representation.
Virtual geographic environment‐based integrated rockfall risk simulation method for canyon bridges
Authors: Ding Yulin , Wu Yuting , Zhu Qing , Zhang Liguo , Sun Qianqian , Wang Weixi 
Published: March 2023

AbstractBridges located in mountainous areas are vulnerable to rockfall accidents, posing a threat to bridge engineering construction and operation safety in these regions. Under the coupling effect of complex environments and engineering disturbances, integrated rockfall risk simulation has become increasingly important for canyon bridge structural protection in long‐term construction and operation phases. One of the main scientific challenges in rockfall risk simulation is studying the interaction between rockfalls and the topography and engineering environments during consecutive contacts. To systematically simulate the integrated bridge rockfall risk, an integrated construction of multivariable elements coupled with rockfall risk environments and scenarios is required. In this article, we proposed a VGE‐based integrated rockfall scenario simulation method that uses the “associated representation—integrated modelling—interactional simulation” core strategy. Our method constructs a virtual rockfall risk environment by fusing multisource data to represent rockfall factors that induce rockfall disasters, hazard‐forming environments, and elements at risk. We design rockfall scenarios under different bridge engineering construction conditions and extreme environmental conditions to analyze the interactional rockfall risks. The results demonstrate that our method enables a systematic analysis of the potential integrated rockfall risk, providing realistic reference value for the timely and effective disposal of emergencies, and reducing the harm and losses caused by such emergencies.
Comparison of agarose gel and capillary zone electrophoresis methods with preliminary reference interval generation using capillary zone electrophoresis in bald eagles (Haliaeetus leucocephalus)
Authors: da Fonseca Leandro Abreu , Montiani‐Ferreira Fabiano , Soto Jeny , Jones Michael P. , Zagaya Nancy , Cray Carolyn 
Published: March 2023

AbstractBackgroundElectrophoresis can be used to aid in the diagnosis of different diseases in avian species. Capillary zone electrophoresis (CZE) is an automated method that is proposed to be superior to the dye methods used in agarose gel electrophoresis (AGE). However, reference intervals (RIs) for CZE in avian species and comparison studies between electrophoretic methods are lacking.ObjectivesThe goals of the current study were to compare AGE and CZE methods and determine reference intervals for CZE using plasma from bald eagles (Haliaeetus leucocephalus).MethodsHeparinized plasma samples from 44 bald eagles (mean age 18.7 years) under managed care were examined by AGE and CZE. Method comparison analyses were completed, as well as the generation of preliminary RIs using the CZE method and ASVCP guidelines.ResultsPassing‐Bablok regression and Bland–Altman plots demonstrate that these methods are not equivalent. All fractions were significantly correlated between the methods except for alpha 1 globulin. Inter‐assay and intra‐assay CVs for CZE were lower or comparable to AGE and ranged from 2.4% to 15.4%, and 0.8% to 8.3%, respectively. CZE resolved more fractions than AGE with two fractions observed in the beta and gamma region vs one for AGE in each region.ConclusionsCZE provided improved resolution and reproducibility for the quantitation of protein fractions in the bald eagle. Although most fraction results correlated with AGE, these methods were judged as not equivalent, necessitating method‐specific Rls. Reference intervals generated from a limited number of mostly aged individuals under managed care should be considered preliminary; additional studies will aid in the production of more robust intervals.
Dual effects of extra virgin olive oil in acute wounds
Authors: Donato‐Trancoso Aline , V. de Carvalho Faria Regina , C. de S. Ribeiro Bianca , Nogueira Jeane S. , Atella Geórgia C. , Chen Lin , Romana‐Souza Bruna 
Published: March 2023

AbstractExtra virgin olive oil (EVOO) has proved beneficial effects in skin wound healing of chronic lesions; however, the effects of EVOO in acute wounds are not completely understood. This study investigated the effects of short‐term and long‐term administration of a diet rich in EVOO on acute wound healing. To check this, mice were fed with a diet rich in EVOO for 1 week (short term), 1 month, or 3 months (long term). The control group received a standard diet. Mouse macrophages were treated in vitro with EVOO or hydroxytyrosol (HT), which is the main EVOO polyphenol. Short‐term administration of an EVOO rich diet in vivo increased lipid peroxidation and mRNA levels of pro‐inflammatory cytokine levels and impaired acute wound closure. In contrast, long‐term administration of an EVOO rich diet resulted in increased mRNA levels of anti‐inflammatory cytokines and enhanced acute wound closure. In both in vivo and in vitro assays, the administration of EVOO or HT resulted in a predominantly anti‐inflammatory macrophage phenotype. In conclusion, a diet rich in EVOO has a positive effect on acute wound healing that is dependent on the duration of EVOO administration. Short‐term EVOO diet supplementation increases oxidative damage and pro‐inflammatory responses, which impaired acute wound closure. On the other hand, long‐term EVOO supplementation reduces oxidative damage and enhances anti‐inflammatory responses, which improved acute wound closure. The effects of EVOO on oxidation and inflammation in acute wounds are linked to the EVOO polyphenol HT.
A Survey of Different Theories of Translation in Cultural Studies
Authors: Hutauruk Bertaria Sohnata , Fatmawati Endang , Al-Awawdeh Nabil , Oktaviani Reni , Sobirov Bobur , Irawan Bambang 
Published: March 2023

The need for translation for communication between speakers of various language groups makes the statement that translation has been around for as long as language itself seem almost obvious. Since translating is such an essential task, many different ideas and theoretical reflections have been developed to help guide the process. The study of translation theory focuses on the processes involved in identifying the categories that underpin translation and the widest possible variety of texts and materials subject to translation. Any background theory of translation concerned with a text's context may include techniques that ought to be taken to solve issues and challenges in specific challenging texts. The purpose of this research is to provide translators with theoretical guidelines for practical translation by conducting a comprehensive survey of the various theories of translation as its primary emphasis and then reporting the findings within the direction of the premises of the theories and the manner in which they have been applied in practical translation. The study adopts a simple qualitative approach in connection with textual analysis. Data was collected through a simple google search of studies in translation theories. The findings of the study provide an indication that seven primary or categorial theories of translation are prevalent in the existing body of research. These theories include the philological theories, the philosophical theories, the linguistic theories, the functional theories (text-type theory, translational action theory, and Skopos theory), the Sociolinguistic theories (Interpretative theory), the Systems theories (Poly-systems theory, manipulation theory, and aesthetic theory), and the Relevance theory of translation. These theories directly underpin different perceptions and procedural systems in conducting practical translation. It was also discovered that implementing different translation strategies and methods is usually premised on the foundations of some theories.
Neuro-Linguistic Programming as an Instructional Strategy to Enhance Foreign Language Teaching
Authors: Purnama Yulian , Sobirov Bobur , Ino La , Handayani Fitriah , Al-Awawdeh Nabil , Safitri Wiena 
Published: March 2023

Teachers of foreign languages use various methods and resources to facilitate interaction between themselves and their pupils. Research into the communicative aspects of teaching and learning foreign languages has benefited from recent breakthroughs attributable to the progress made in Neuro-linguistic Programming (NLP). This research delves into using Neuro-linguistic Programming (NLP) in the classroom to better instructors' communicative abilities with their students. This paper concentrates on the implementation of Neuro-Linguistic Programming (NLP) in learning a foreign language. in a bid to discover flaws and issues pertaining to the traditional mechanism of learning. The use of Neuro-Linguistic Programming (NLP) in the teaching of Foreign Language (FL) has a great deal of promise due to the fact that the effectiveness of NLP has been shown by the progress that a number of nations have achieved as a result of its application. A questionnaire was distributed to 150 foreign language instructor who were chosen at random from a variety of high schools. This allowed for the collection of information on teachers' preparedness. The findings of the study revealed that a larger proportion of foreign language instructors possess comparable understanding of NLP. Furthermore, the majority of these instructors demonstrated optimistic reactions and a readiness to utilize NLP in the classroom when instructing students in foreign languages. The level of information that each person had influenced how they thought. Thus, instructors who had a deeper understanding of NLP had a greater interest in and motivation for the application of the theory in foreign language settings. The findings of this research demonstrate how NLP may assist both instructors and students in accomplishing their objectives learning a foreign language.
Rumor Detection on Social Media Using Deep Learning Algorithms with Fuzzy Inference System for Healthcare Analytics System Using COVID-19 Dataset
Authors: Rathakrishnan Akila , Sathiyanarayanan Revathi 
Published: March 2023

Spreading rumors on social media is a phenomenon that has destructive implication of societal interaction, diverts attention toward destructive behavior. The impact will be more influenced in healthcare management. This research aims to detect the rumors and identify the sources using deep learning algorithms. In our proposed system, after pre-processing, the tweet comments are extracted from topics and ranked as deny, support, query and comment. Then the comments are classified as positive, negative and neutral using Artificial Neural Network Neuro-fuzzy Inference System Spline-based pi-shaped Membership Function (ANISPIMF). Then the negative comments are classified into offensive, violence, misogyny and hate mongering by using Improved Deep Learning Neural Network (IDLNN) which is the combination of Deep Neural Network with Cuckoo Search–Flower Pollination Algorithm to optimize the weight values. The optimized ANISPIMF performs very well for the COVID-19 dataset in terms of Accuracy, Precision and Recall. The proposed system attains better performance and efficiency when weighted against prevailing methodologies — regarding the performance measures, there is an improvement of accuracy by 0.6%, recall by 0.7%, and precision by 1%, together with an [Formula: see text]1-score of 1.2% than the Multiloss Hierarchical Bi-LSTM with Attenuation Factor (MHA).
A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2–Bispecific Antibody for Combination Cancer Therapy
Authors: El Zawily Amr , Vizeacoumar Frederick S. , Dahiya Renuka , Banerjee Sara L. , Bhanumathy Kalpana K. , Elhasasna Hussain , Hanover Glinton , Sharpe Jessica C. , Sanchez Malkon G. , Greidanus Paul , Stacey R. Greg , Moon Kyung-Mee , Alexandrov Ilya , Himanen Juha P. , Nikolov Dimitar B. , Fonge Humphrey , White Aaron P. , Foster Leonard J. , Wang Bingcheng , Toosi Behzad M. , Bisson Nicolas , Mirzabekov Tajib A. , Vizeacoumar Franco J. , Freywald Andrew 
Published: March 2023

Abstract

Purpose:
Accumulating analyses of pro-oncogenic molecular mechanisms triggered a rapid development of targeted cancer therapies. Although many of these treatments produce impressive initial responses, eventual resistance onset is practically unavoidable. One of the main approaches for preventing this refractory condition relies on the implementation of combination therapies. This includes dual-specificity reagents that affect both of their targets with a high level of selectivity. Unfortunately, selection of target combinations for these treatments is often confounded by limitations in our understanding of tumor biology. Here, we describe and validate a multipronged unbiased strategy for predicting optimal co-targets for bispecific therapeutics.

Experimental Design:
Our strategy integrates ex vivo genome-wide loss-of-function screening, BioID interactome profiling, and gene expression analysis of patient data to identify the best fit co-targets. Final validation of selected target combinations is done in tumorsphere cultures and xenograft models.

Results:
Integration of our experimental approaches unambiguously pointed toward EGFR and EPHA2 tyrosine kinase receptors as molecules of choice for co-targeting in multiple tumor types. Following this lead, we generated a human bispecific anti-EGFR/EPHA2 antibody that, as predicted, very effectively suppresses tumor growth compared with its prototype anti-EGFR therapeutic antibody, cetuximab.

Conclusions:
Our work not only presents a new bispecific antibody with a high potential for being developed into clinically relevant biologics, but more importantly, successfully validates a novel unbiased strategy for selecting biologically optimal target combinations. This is of a significant translational relevance, as such multifaceted unbiased approaches are likely to augment the development of effective combination therapies for cancer treatment.
See related commentary by Kumar, p. 2570
Impaired Maternal‐Fetal Environment and Risk for Preoperative Focal White Matter Injury in Neonates With Complex Congenital Heart Disease
Authors: Licht Daniel J. , Jacobwitz Marin , Lynch Jennifer M. , Ko Tiffany , Boorady Timothy , Devarajan Mahima , Heye Kristina N. , Mensah‐Brown Kobina , Newland John J. , Schmidt Alexander , Schwab Peter , Winters Madeline , Nicolson Susan C. , Montenegro Lisa M. , Fuller Stephanie , Mascio Christopher , Gaynor J. William , Yodh Arjun G. , Gebb Juliana , Vossough Arastoo , Choi Grace H. , Putt Mary E. 
Published: March 2023

Background
Infants with congenital heart disease (CHD) are at risk for white matter injury (WMI) before neonatal heart surgery. Better knowledge of the causes of preoperative WMI may provide insights into interventions that improve neurodevelopmental outcomes in these patients.

Methods and Results

A prospective single‐center study of preoperative WMI in neonates with CHD recorded data on primary cardiac diagnosis, maternal‐fetal environment (MFE), delivery type, subject anthropometrics, and preoperative care. Total maturation score and WMI were assessed, and stepwise logistic regression modeling selected risk factors for WMI. Among subjects with severe CHD (n=183) who received a preoperative brain magnetic resonance imaging, WMI occurred in 40 (21.9%) patients. WMI prevalence (21.4%–22.1%) and mean volumes (119.7–160.4 mm
3
) were similar across CHD diagnoses. Stepwise logistic regression selected impaired MFE (odds ratio [OR], 2.85 [95% CI, 1.29–6.30]), male sex (OR, 2.27 [95% CI, 1.03–5.36]), and older age at surgery/magnetic resonance imaging (OR, 1.20 per day [95% CI, 1.03–1.41]) as risk factors for preoperative WMI and higher total maturation score values (OR, 0.65 per unit increase [95% CI, 0.43–0.95]) as protective. A quarter (24.6%; n=45) of subjects had ≥1 components of impaired MFE (gestational diabetes [n=12; 6.6%], gestational hypertension [n=11; 6.0%], preeclampsia [n=2; 1.1%], tobacco use [n=9; 4.9%], hypothyroidism [n=6; 3.3%], and other [n=16; 8.7%]). In a subset of 138 subjects, an exploratory analysis of additional MFE‐related factors disclosed other potential risk factors for WMI.

Conclusions
This study is the first to identify impaired MFE as an important risk factor for preoperative WMI. Vulnerability to preoperative WMI was shared across CHD diagnoses.
Thymidine Phosphorylase Deficiency or Inhibition Preserves Cardiac Function in Mice With Acute Myocardial Infarction
Authors: Du Lili , Yue Hong , Rorabaugh Boyd R. , Li Oliver Q. Y. , DeHart Autumn R. , Toloza‐Alvarez Gretel , Hong Liang , Denvir James , Thompson Ellen , Li Wei 
Published: March 2023

Background
Ischemic cardiovascular disease is the leading cause of death worldwide. Current pharmacologic therapy has multiple limitations, and patients remain symptomatic despite maximal medical therapies. Deficiency or inhibition of thymidine phosphorylase (TYMP) in mice reduces thrombosis, suggesting that TYMP could be a novel therapeutic target for patients with acute myocardial infarction (AMI).

Methods and Results

A mouse AMI model was established by ligation of the left anterior descending coronary artery in C57BL/6J wild‐type and TYMP‐deficient (
Tymp

−/−

) mice. Cardiac function was monitored by echocardiography or Langendorff assay. TYMP‐deficient hearts had lower baseline contractility. However, cardiac function, systolic left ventricle anterior wall thickness, and diastolic wall strain were significantly greater 4 weeks after AMI compared with wild‐type hearts. TYMP deficiency reduced microthrombus formation after AMI. TYMP deficiency did not affect angiogenesis in either normal or infarcted myocardium but increased arteriogenesis post‐AMI. TYMP deficiency enhanced the mobilization of bone marrow stem cells and promoted mesenchymal stem cell (MSC) proliferation, migration, and resistance to inflammation and hypoxia. TYMP deficiency increased the number of larger MSCs and decreased matrix metalloproteinase‐2 expression, resulting in a high homing capability. TYMP deficiency induced constitutive AKT phosphorylation in MSCs but reduced expression of genes associated with retinoid‐interferon‐induced mortality‐19, a molecule that enhances cell death. Inhibition of TYMP with its selective inhibitor, tipiracil, phenocopied TYMP deficiency, improved post‐AMI cardiac function and systolic left ventricle anterior wall thickness, attenuated diastolic stiffness, and reduced infarct size.

Conclusions
This study demonstrated that TYMP plays an adverse role after AMI. Targeting TYMP may be a novel therapy for patients with AMI.
Deciding Whether to Take Sacubitril/Valsartan: How Cardiologists and Patients Discuss Out‐of‐Pocket Costs
Authors: Rao Birju R. , Akrobetu Dennis J. , Dickert Neal W. , Nguyen Thuy‐Vi , Davis J. Kelly , Campagna Ada , Mitchell Andrea R. , Sharma Anu , Speight Candace D. , Barks Mary Carol , Farley Samantha , Gutterman Sophia , Santanam Taruni , Ubel Peter A. 
Published: March 2023

Background
Out‐of‐pocket costs have significant implications for patients with heart failure and should ideally be incorporated into shared decision‐making for clinical care. High out‐of‐pocket cost is one potential reason for the slow uptake of newer guideline‐directed medical therapies for heart failure with reduced ejection fraction. This study aims to characterize patient–cardiologist discussions involving out‐of‐pocket costs associated with sacubitril/valsartan during the early postapproval period.

Methods and Results
We conducted content analysis on 222 deidentified transcripts of audio‐recorded outpatient encounters taking place between 2015 and 2018 in which cardiologists (n=16) and their patients discussed whether to initiate, continue, or discontinue sacubitril/valsartan. In the 222 included encounters, 100 (45%) contained discussions about cost. Cost was discussed in a variety of contexts: when sacubitril/valsartan was initiated, not initiated, continued, and discontinued. Of the 97 cost conversations analyzed, the majority involved isolated discussions about insurance coverage (64/97 encounters; 66%) and few addressed specific out‐of‐pocket costs or affordability (28/97 encounters; 29%). Discussion of free samples of sacubitril/valsartan was common (52/97 encounters; 54%), often with no discussion of a longer‐term plan for addressing cost.

Conclusions
Although cost conversations were somewhat common in patient–cardiologist encounters in which sacubitril/valsartan was discussed, these conversations were generally superficial, rarely addressing affordability or cost‐value judgments. Cardiologists frequently provided patients with a course of free sacubitril/valsartan samples without a plan to address the cost after the samples ran out.