bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of antiepileptic drugs on bone metabolism in children using biochemical markers: a case control study
Authors: V. Rajan Gopika , Sreenivasaiah Bharathi , Lunavath Narayana , Yerroju Kodandapani 
Published: June 2023

Background: Most epileptic patients are diagnosed and treated in childhood and adolescence and this period is crucial in attaining peak bone mass. Few studies are conducted on children showing long term effects of AEDs on bone metabolism. So, the present study was conducted to evaluate correlation of long-term uses of AEDs with changes in bone metabolism using biochemical marker.
Methods: Total of 140 subjects divided into 70cases - Epileptic children aged 1 to 14 years who are on AEDs for at least 6months and 70 Controls- Children aged 1 to 14 years not on AEDs. Semi structured questionnaire was used to collect demographic data. Venous blood samples were collected and sent for laboratory investigations like Serum vitamin D, serum calcium, serum phosphorus, Parathyroid hormone and alkaline phosphatase levels.
Results: Mean age of study population in cases was 7.74±4.43 years and in controls was7.65±3.72 years. Mean vitamin-D, calcium, phosphorus decreases while PTH and ALP increases with duration of treatment in epileptic children with a statistically significant difference between them (P<0.05). Mean serum vitamin D level in cases and in controls was with no statistical significant difference between two groups. Mean serum calcium, phosphorus, parathormone and alkaline phosphatase levels in cases and controls all had a statistically significant mean difference between two groups. Serum vitamin-D, serum calcium, serum phosphorus was low in patients treated with enzyme inducing when compared to non-enzyme inducing drugs in epileptic children with a statistically significant difference between them (P<0.05). Serum vitamin-D, serum calcium, serum phosphorus was high in patients on monotherapy when compared polytherapy in epileptic children with a statistically significant difference between them (P<0.05).
Conclusions: Present study shows that children on AEDs for longer duration had low bone mineral parameters when compared to normal children. The study emphasizes that mineral levels need to be monitored in epileptic patients as they are at a higher risk of falling and bone fractures.
Mu‘tezilî Tanımlar Literatürünün Kayıp Halkası: Kādî Abdülcebbâr’ın Ḥudûdü’l-elfâẓ’ı –İnceleme ve Neşir–
Authors: ÇETİN Serkan , KILAVUZ Ulvi Murat 
Published: June 2023

İslâm düşüncesinde farklı alanlarda disiplinlerin/ilimlerin teşekkülüne müteakip disiplinlerin/ilimlerin kendilerine özgü kavramları ve terminolojileri de oluşmaya başlamış ve daha sonraki süreçte bu kavramsallaştırmaya katkı sunacak müstakil tanım (ḥudûd) risâleleri telif edilerek her disiplindeki/ilimdeki kavramın anlam ve kullanım çerçevesi daha da netleştirilmiştir. Temel olarak kullanılan kavramın ıstılahî anlamının belirlenmesi ve böylece takip edilen kelâmî temayülün desteklenmesi adına, kelâm ilmi özelinde de bu türe ait eserler kaleme alınmıştır. Kelâm ilmi özelinde bu alana en büyük katkıyı ise şüphesiz Mu‘tezilî kelâmcılar vermiştir. Nitekim başta Kādî Abdülcebbâr (ö. 415/1025) olmak üzere öğrencileri Ebû Reşîd en-Nîsâbûrî (ö. 420/1029’dan sonra) ve İbn Şervîn (V./XI. yüzyılın ilk yarısı) gibi isimler tarafından kelâmî kavramları ihtiva eden özgün risâleler telif edilmiştir. Zeydî kelâmcı ve fakih Ebü’l-Kāsım el-Büstî’nin (ö. 420/1029 civarı) henüz bir nüshasına ulaşılamayan Tehẕîbü’l-ḥudûd’u da bahsedilen eserlerle eş zamanlıdır. Bu gelenek, İmâmî-Mu‘tezilî çizgide Ebû Ca‘fer et-Tûsî’nin (ö. 460/1067), kurgusu ve yer yer yaptığı açıklamalar itibariyle mûcez bir kelâm eseri hüviyeti de taşıyan el-Muḳaddime fi’l-medḫal ilâ ṣınâʿati ʿilmi’l-kelâm’ı ve Şerîf el-Murtazâ’ya (ö. 436/1044) nispet edilen el-Ḥudûd ve’l-ḥaḳāʾiḳ isimli eserde yansımasını bulmuştur. Ebû Ca‘fer el-Mukrî en-Nîsâbûrî’nin (ö. VI./XII. yy.’ın ortaları [?]) el-Ḥudûd’u ise bu gelenek içerisindeki en hacimli örnek olarak göze çarpmaktadır.
Mu‘tezilî gelenek içerisinde mevcut eserler arasında ilki olması açısından bu türe ait en önemli eser, yakın zamana kadar kayıp olduğu düşünülen ve tarafımızdan keşfedilen bir mecmua içerisinde, önemli bazı diğer Zeydî-Mu‘tezilî eserlerle birlikte bulunan, Kādî Abdülcebbâr’ın Ḥudûdü’l-elfâẓ isimli risâlesidir. Genel olarak kelâmî kavramların yer aldığı ve kısmen fıkha ve mezhepler tarihine ilişkin kavramların da bulunduğu bu risâlede Kādî Abdülcebbâr dile dayalı bir tanım teorisi ortaya koymuştur. Buradaki yaklaşımı, el-Muğnî’sinde tanım ve tanımlamaya yönelik ortaya koyduğu görüşlerle uyumludur. Nitekim klasik mantıkta beş tümel üzerinden yürütülen tanım (ḥad) ve betim (resm) yerine, ele alınan kavramın manasına mutabık ve ondan daha açık olan bir lafız üzerinden yapılan lügavî tanım metodunu benimsemiş ve bu doğrultuda ele aldığı kavramın kısa bir tanım ve açıklamasına yer vermiştir. Bu durum, önceki Mu‘tezilî kelâmcılar tarafından felsefeye mesafeli yaklaşmaları nedeniyle Aristotelesçi tanım anlayışının alternatifi olarak kullanılan dile dayalı tanım anlayışının, Kādî Abdülcebbâr tarafından da tevarüs edildiğini açıkça göstermektedir. Ebû Reşîd en-Nîsâbûrî’nin el-Ḥudûd’u gibi Kādî’yi takip eden dönem bazı kaynaklarda görülen yaklaşım da onun etkisini imlemektedir.
Formulation and Evaluation of the Anti-inflammatory, Anti-oxidative, and Anti-remodelling Effects of the Niosomal Myrtenol on the Lungs of Asthmatic Rats
Authors: Rajizadeh Mohammad Amin , Nematollahi Mohammad Hadi , Jafari Elham , Bejeshk Mohammad Abbas , Mehrabani Mehrnaz , Rostamzadeh Farzaneh , Fekri Mitra Samareh , Najafipour Hamid 
Published: June 2023

Asthma is a common chronic allergic disease that affects a significant percentage of the world’s population. Niosomes are nanoparticles consisting of non-ionic surfactants that can be used for drug delivery. This research was designed to investigate the impacts of inhalation of simple and niosomal forms of myrtenol against adverse consequences of asthma in rats.
Asthma induction was performed via injection of ovalbumin, followed by its inhalation. Niosomes were created by a heating protocol, and their physicochemical features were evaluated. Forty-nine male Wistar rats were allotted into 7 groups (n=7 each): Control (CTL), vacant niosome (VN), Asthma, Asthma+VN, Asthma+SM (simple myrtenol), Asthma+NM (niosomal myrtenol), and Asthma+B (budesonide). Lung remodeling, serum immunoglobulin E (IgE), inflammatory and cytokines, and antioxidant factors in the lung tissue and bronchoalveolar fluid (BALF), as well as), were evaluated.
The results showed that myrtenol-loaded niosomes had appropriate encapsulation efficiency, kinetic release, size, and zeta potential. The thickness of the epithelial cell layer in the lungs, as well as cell infiltration, fibrosis, IgE, reactive oxygen species, interleukin (IL)-6, and tumor nuclear factor alpha (TNF-α) levels, decreased significantly. In contrast, superoxide dismutase and glutathione peroxide activity increased significantly in the serum and BALF of the treated groups. The niosomal form of myrtenol revealed a higher efficacy than simple myrtenol and was similar to budesonide in ameliorating asthma indices. Inhalation of simple and niosomal forms of myrtenol improved the detrimental changes in the asthmatic lung. The niosomal form induced more prominent anti-asthmatic effects comparable to those of budesonide.
Anti-inflammatory Effects of Ziziphus Jujube Mill on LPS-induced Acute Lung Injury in Mice
Authors: Shaban Parastoo , Honari Niloofar , Erfanian Nafiseh , Hosseini Mehran , Safarpour Hossein , Nasseri Saeed 
Published: June 2023

Ziziphus Jujuba Mill (Z.J) is a well-known ethnomedical source of biologically active compounds with anti-inflammatory effects. However, its significance in acute lung injury (ALI) has never been studied. The present study aimed to explore whether Z.J could attenuate lipopolysaccharide (LPS)-induced inflammatory responses in an experimental model of ALI.
Male BALB/c mice received an intratracheal administration of LPS (n=32) or phosphate buffer saline (PBS) (control, n=8). Within 1, 11, and 23 h post-LPS injection, mice were randomly assigned to receive intraperitoneal treatments of saline, dexamethasone (2 mg/kg), and 100 and 200 mg/kg of Z.J extracts, respectively. 24 h after intratracheal administration of LPS, bronchoalveolar lavage fluid and lung tissues were harvested and assessed for inflammatory cell influx, tumor necrosis factor-α (TNF-α) levels, and histological assessments.
Treatment with Z.J extracts (100 and 200 mg/kg) and dexamethasone effectively reduced LPS-induced neutrophil and other inflammatory cell influx into the lung tissue compared to the untreated group. additionally, both doses of Z.J extracts (100 and 200 mg/kg) significantly ameliorated the lung wet-to-dry ratio and histopathological damage. Furthermore, compared to the untreated ALI mice, Z.J extract at the highest dose could significantly reduce the TNF-α level.
The present findings indicated that Z.J could effectively ameliorate LPS-induced ALI inflammatory responses and might be considered a promising alternative therapy for the ALI phenotype.
Serologic Biomarkers in Pemphigus Monitoring: C-reactive Protein, Macrophage Migration Inhibitory Factor, and Prolactin Levels Versus Autoantibody Assays
Authors: Mortazavi Hossein , Saeidi Vahide , Balighi Kamran , Esmaili Nafiseh , Teimourpour Amir , Daneshpazhooh Maryam , Hamzelou Shahin , Saffarian Zahra , Fazli Jafar Taghizadeh 
Published: June 2023

Evaluation and monitoring of pemphigus vulgaris (PV) typically involve autoantibody detection by enzyme-linked immunosorbent assay (ELISA) and indirect immunofluorescence (IIF). We aimed to determine the levels of antipemphigus immunoglobulin (Ig) G autoantibodies using ELISA and IIF (as standard biomarkers), and compare it to prolactin, macrophage migration inhibitory factor (MIF), and C-reactive protein (CRP) (as nonstandard biomarkers) to determine which of these non-standard biomarkers is appropriate for PV monitoring. The experiment was performed before and during therapy.
Anti-Dsg immunoglobulin G autoantibodies were measured using ELISA and IIF (as standard biomarkers) versus prolactin, MIF, and CRP (nonstandard), before 1 and 3 months after the treatment. Before beginning the treatment, the severity of the disease was determined using the pemphigus disease area Index (PDAI). We enrolled 60 newly diagnosed patients with PV (32 men and 28 women; mean age=43.8±14.2 years).
Before treatment, the levels of anti-Dsg1, anti-Dsg3, and IIF were high and had a significant relationship with PDAI. PDAI also had a connection with the levels of CRP and prolactin. The anti-Dsg1, anti-Dsg3, IIF, and CRP titers decreased in patients treated with conventional (prednisolone plus azathioprine) and rituximab therapy during and after treatment.
In conclusion, anti-Dsg1, anti-Dsg3, and IIF autoantibody titers remain standard biomarkers for assessing disease activity, severity, and PV monitoring. The trend of CRP was similar to that of anti-Dsg1, anti-Dsg3, and IIF. Thus, CRP may be used for PV monitoring.
The Evaluation of Electromyography Biofeedback on Proprioception and Balance in Healthy Young Athletes
Authors: Daryabor Aliyeh , Naghizad Javad , Jamehbozorgi Aliasghar , Kalantari Khosro Khademi , Rezaei Mehdi 
Published: June 2023

Introduction: We evaluated the effect of electromyography biofeedback on proprioception and functional balance in healthy young athletes.
Materials and Methods: In this clinical trial, 24 athletes were randomly divided into two study (n=12) and control (n=12) groups. The study group received rehabilitation exercises, including one-foot standing, squatted standing, and isometric contraction of quadriceps muscle at different knee angles, including 30, 45, and 90 degrees of knee flexion along with electromyography biofeedback. The control group received only rehabilitation exercises without electromyography biofeedback. Exercises were performed by both groups for a 4-week period in three sessions per week. Functional balance and proprioception before and after exercises were measured using the star excursion balance test and a system consisting of digital photography non-reflective markers, respectively. The data of the center of pressure and time of vertical ground reaction force using a force plate was also collected to evaluate static balance and dynamic balance, respectively.
Results: The absolute error in knee joint reconstruction for 30° (P=0.005), 45° (P=0.001), and 90° (P=0.033) angles significantly decreased after the intervention in the study group compared to the control group. Star excursion balance test scores in all directions did not show any significant differences between the two groups (P>0.05), except for the anterior-lateral direction (P=0.03). Moreover, all variables related to static and dynamic balance did not show a significant difference between two the groups after the interventions (P>0.05).
Conclusion: The electromyography biofeedback intervention can probably be used as a rehabilitation protocol in recovering and healing proprioception injuries resulting from sports injuries.
Effectiveness of Cognitive Orientation to Daily Occupational Performance in Parkinson’s Disease: A Case Report
Authors: Taheri Atefeh , Tahmineh Mousavi Seyedeh , Dalvand Hamid , Almasi-Hashiani Amir 
Published: June 2023

Introduction: Parkinson’s disease is a chronic progressive neurodegenerative disorder causing impaired motor function and various non-motor symptoms. One of the most common problems in Parkinson’s patients is occupational performance problems. The cognitive orientation to daily occupational performance (CO-OP) is one of the client-centered and problem-solving approaches in occupational therapy evaluations and interventions. This study aims to determine the effectiveness of the CO-OP approach on perceived satisfaction and occupational performance in a 62-year-old woman with Parkinson’s disease.
Case Description: The client was a 62-year-old woman with moderate cognitive impairment, stage 3 on the Hoehn and Yahr scale, and signs of depression. In our case study, the outcome measures were the Canadian occupational performance measure (COPM), functional independence measure (FIM), Montreal cognitive assessment (MOCA), and Beck depression inventory-II (BDI-II). We administered the CO-OP intervention for six weeks. Sessions were performed twice a week for one hour per session.
Results: The results indicate that the CO-OP intervention improves the client’s satisfaction, occupational performance, and functional independence. Although the results from this single case cannot be generalized, the findings suggest that CO-OP intervention may help improve satisfaction and occupational performance in adults with Parkinson’s disease. Further investigation is necessary.
Conclusion: These results suggest that CO-OP can be a valuable occupational therapy interventions for individuals with Parkinson’s disease. We recommend that occupational therapists consider using this approach in their practice to improve the occupational performance of their patients with Parkinson’s disease.
Investigation of the filling-overflow behavior of corrosion products in reinforced mortar
Authors: Zhao Yuxi , Xu Dandan , Wang Yuzhou , Wang Haiyu 
Published: June 2023

The investigation of the filling-overflow behavior of corrosion products in concrete is important for accurately predicting corrosion-induced concrete cover cracking. This paper utilizes the ethylene diamine tetra acetic acid (EDTA) titration method to quantitatively study the iron content in each zone of corroded reinforced mortar specimens. Based on this, the proportion and distribution of corrosion products are analyzed. Results show that approximately 50% of the corrosion products are transported to the mortar and corrosion products show a transport pattern to the surrounding low-concentration area in mortar. The direction of ion invasion on the mortar specimen does not exhibit a significant impact on the transport of corrosion products, while both the geometric size and quality of the mortar specimen affect the transport of corrosion products. Furthermore, the proposed method employs EDTA titration to quantify the filling and overflow of corrosion products, providing a valuable approach for further experimental research.
Solar Cooling for the Sunbelt Regions: Climatic Conditions & Applications
Authors: Gurtner Richard , Schmetzer Tobias , Riepl Manuel 
Published: June 2023

In general, climatic conditions and typical applications for (solar) cooling heavily depend on the location. In order to be able to deduce regionally specific requirements for solar cooling systems, it is therefore obvious to use geographical data. To process such data a Geographic information system (GIS) is needed. GIS are able to capture, store, check, and display data related to positions on Earth’s surface. Most geographical data relevant for this application are already available from various sources, such as solar radiation data, climatic data, population data etc.
Wpływ pandemii COVID-19 na sposób korzystania z usług bankowych oraz na postrzeganie banków w Polsce – na podstawie badania empirycznego
Authors: Rybacka Justyna 
Published: June 2023

Celem głównym artykułu była identyfikacja zmiany sposobów korzystania z usług bankowych przed, jak i w trakcie pandemii COVID-19 oraz weryfikacja tego, jak konsumenci postrzegają współcześnie instytucje bankowe. W artykule sformułowano dwie hipotezy. Pierwsza odnosi się do tego, że klienci banków przeszli w znaczącej części na zdalne formy korzystania z usług bankowych w okresie koronawirusa. Z kolei druga teza odwołuje się do tego, iż wykorzystanie bankowości internetowej spowodowało, że jej użytkownicy przywiązują większą uwagę do aspektu bezpieczeństwa niż przed pandemią.
Na potrzeby niniejszego opracowania przygotowano i przeprowadzono badanie empiryczne. Podstawowym celem badania była identyfikacja zmian w korzystaniu z usług bankowych w okresie koronawirusa oraz weryfikacja postrzegania wizerunku banków w dobie ostatnich wydarzeń ekonomiczno-społecznych. Badanie przeprowadzono metodą ankietową, w której wykorzystywany był kwestionariusz ankiety.
Na podstawie przeprowadzonego badania można zauważyć, że głównie osoby po 50 roku życia przeniosły się na zdalna formę kontaktu z bankiem na skutek pandemii. We wskazanej grupie wiekowej w początkowej fazie koronawirusa popularność zyskała bankowość mobilna. Przed pandemią 26% ankietowanych deklarowało, że odbywało wizyty w banku w celu wpłaty lub wypłaty środków z rachunku bankowego. W trakcie pandemii tylko już 1% badanych deklarował, że odbywał bezpośrednie spotkanie z doradcą bankowym w celu skorzystania z usług bankowych. 33% respondentów stwierdziło, że zmiana sposobu korzystania z oferty banku pozwoliła oszczędzić im czas, a 12% wskazało, że powodem zmiany była obawa o zdrowie i życie. Na uwagę zasługuje fakt, że aż 42% ankietowanych wskazało, że po pandemii COVID-19 zwróciło większą uwagę na bezpieczeństwo w sieci. Wzrost cyfryzacji wśród społeczeństwa przełożył się na wzrost świadomości w kwestii przestępstw finansowych popełnianych w Internecie.
FAKTOR PREDISPOSISI IMPLEMENTASI SUAMI SIAGA SELAMA PANDEMI COVID-19 DI KABUPATEN JEMBER
Authors: Kusumawardani Devi Arine , Wahyuningtyias Farida 
Published: June 2023

Angka kematian Ibu meningkat selama masa pandemic COVID-19 pada tahun 2020 sebagai dampak kebijakan pembatasan kegiatan sosial. Akses masyarakat terhadap layanan kesehatan maternal menjadi terbatas sehingga penanganan komplikasi ibu hamil, bersalin, dan nifas menjadi terlambat. Suami memegang peranan penting dalam mencegah terjadinya keterlambatan tersebut melalui implementasi program Suami Siaga. Tujuan penelitian adalah untuk mengidentifikasi faktor predisposisi yang berhubungan dengan implementasi suami siaga. Penelitian ini merupakan penelitian analitik observasional dengan desain studi cross-sectional di wilayah Pusat Kesehatan Masyarakat Panti, kabupaten Jember selama Agustus sampai dengan November 2020. Sampel penelitian sejumlah 170 orang yang dipilih secara acak menggunakan cluster random sampling. Instrumen penelitian menggunakan kuesioner terstruktur untuk mengukur implementasi suami siaga kemudian data yang diperoleh dianalisis menggunakan uji chi-square. Hasil penelitian menunjukkan bahwa sebagian besar suami termasuk dalam kategori suami tanggap dan siaga (85,88%). Faktor predisposisi yang berhubungan dengan implementasi suami siaga antara lain usia suami (p-value = 0,008), pengetahuan suami tentang persiapan persalinan dan pencegahan komplikasi (p-value = 0,002), dan jarak tempat tinggal ke fasilitas kesehatan (p-value = 0,000). Oleh karena itu, tenaga kesehatan di fasilitas pelayanan kesehatan perlu meningkatkan kegiatan edukasi dan sosialisasi terkait program Suami Siaga pada ibu hamil dan suami selama antenatal care sebagai pencegahan kematian ibu selama pandemic COVID-19.
PENGEMBANGAN AGROFORESTRI BERBASIS MANAGEMENT REGIM DI KAWASAN HUTAN JATI
Authors: Susanto Anang - , Parwi Parwi , Winarni Marti 
Published: June 2023

Pengelolaan hutan saat ini harus memberikan akses atau hak izin agar dapat memberikan nilai tambah bagi masyarakat sekitar hutan. Upaya yang dilakukan untuk mendapatkan legalisasi masyarakat dalam mengakses dan mengelola kawasan hutan, pemerintah mengeluarkan kebijakan perhutanan sosial. Pengelolaan lahan hutan dengan sistem management regim sangat memerlukan partisipasi masyarakat, sehingga salah satunya pengelolaan lahan berbasis agroforestry. Tujuan penelitian ini untuk mengetahui peran masyarakat dalam pengelolaan hutan, dalam bidang pengembangan agroforestri. Teknik pengumpulan data yaitu observasi lapangan melalui wawancara langsung. Hasil yang didapatkan dari wawancara petani sebagai responden adalah sangat puas, puas dan kurang puas dengan persentase masing-masing 80%, 10%, 3%. Kepuasan petani terhadap sistem management regim ini dipandang sebagai produk yang telah terbukti ampuh di dalam menghadapi perubahan keamanan hutan dan lingkungan. Hal ini menjadi bukti bahwa pengelolaan secara management regim mampu mendukung kestabilan pangan masyarakat setempat.
Effect of Arbuscular Mycorrhizal Tablets and Sachets on the growth of Pueraria javanica
Authors: Ahmad Namrawati , Akib Muhammad Akhsan , Nurqadri Sri , Syatrawati Syatrawati , Prayudyaningsih Retno 
Published: June 2023

Pueraria javanica (P. javanica) is a type of Leguminosae with a vine growth type with well-fixation nitrogen, so that can be used as a ground cover plant and forage food riched in protein (15-25%). In addition, the beneficial ability in symbiosis with arbuscular mycorrhizal fungi (AMF) has caused this plant to be utilized as the host plant for testing the effectiveness of different dosage forms of AMF on the growth of P. javanica which was carried out in Bukit Harapan sub-district, Parepare City at an altitude of 37.0 m asl with the coordinate point 3°59'30” S and 119°38'43” E. The study was conducted according to a randomized block design (RBD), AMF treatment dosage forms tested was powder (B1)/control, sachet (B2), and tablet (B3). The results showed that the form of AMF did not affect the effectiveness of stimulating the root length growth and volume, as well as the leaf number of P. javanica. AMF in tablet and sachet forms can enrich the AMF dosage form and can be a novelty for this field