bluuebunny/crossref_metadata_2025_split huggingface dataset:
Milk–cereal mix supplementation during infancy and impact on neurodevelopmental outcomes at 12 and 24 months of age: a randomised controlled trial in India
Authors: Upadhyay Ravi Prakash , Taneja Sunita , Strand Tor Arne , Hysing Mari , Koshy Beena , Bhandari Nita , Bahl Rajiv 
Published: December 2022

AbstractInadequate protein intake and lack of micronutrients may affect neurodevelopment in infants. This randomised controlled trial was conducted to measure the effect of two milk–cereal mixes with modest and high amounts of protein and enriched with multiple micronutrients, given between 6 and 12 months, on cognitive, language, motor and behavioural scores at 12 and 24 months of age, compared with no-supplementation. The two supplements were also compared with each other. The study was conducted in urban Delhi, India, and the infants were randomised in a 1:1:1 ratio to the three study groups. At 12 and 24 months of age, 1134 and 1214 children were available, respectively. At 12 months of age, compared with no-supplement group, an increase in the motor scores (mean difference, MD 1·52, 95 % CI: 0·28, 2·75) and a decrease in the infant temperament scores (MD − 2·76, 95 % CI: −4·23, −1·29) in the modest-protein group was observed. Those in the high-protein group had lower socio-emotional scores (MD − 1·40, 95 % CI: −2·43, −0·37) and higher scores on Infant Temperament Scale (MD 2·05, 95 % CI: 0·62, 3·48) when compared with modest-protein group. At 24 months, no significant differences in any of the neurodevelopment scores between the three study groups was found. In conclusion, supplementation with modest amount of protein and multiple micronutrients may lead to short-term small improvements in motor function and infant temperament. There appears no advantage of supplementing with high protein, rather negative effects on infant behaviour were observed
Sublethal effects of growth-regulating insecticides of synthetic and botanical origins on the biological parameters ofSpodoptera frugiperda(Lepidoptera: Noctuidae)
Authors: Martins Liliane N. , Geisler Fernanda C. S. , Rakes Matheus , Araújo Mikael B. , Amandio Dylan T. T. , da Rosa Ana Paula S. A. , Ribeiro Leandro P. , Bernardi Daniel 
Published: December 2022

AbstractThe objective of this study was to evaluate the effects of growth-regulating insecticides of synthetic (e.g., Certero 480 SC, Intrepid 240 SC, Match EC and Mimic 240 SC) and botanical origins (e.g., Azamax 1.2 EC, Agroneem 850 EC, Azact 2.4 EC and Fitoneem 850 EC) on the biological parameters and fertility life table ofSpodoptera frugiperda(J.E. Smith) under laboratory conditions. Larvae were fed insecticides that were incorporated into artificial diets. To develop the fertility life table, the following biological parameters were evaluated: survival at 7 days after infestation (d.a.i) and survivorship at adult eclosion, duration of the neonate-to-adult eclosion period, larval and pupal weights and total fecundity (number of total eggs per female). The results indicated thatS. frugiperdaneonates surviving LC25or LC50concentrations of the evaluated insecticides showed longer larval and egg-to-adult periods, lower larval and pupal weights and reduced fecundity, when compared to the control treatment. Larvae exposed to Azamax at LC25or LC50concentrations showed the greatest increase in generation duration (75 d). In addition,S. frugiperdaadults emerged from pupae when larvae reared on an artificial diet containing growth regulating insecticides of synthetic and botanical origins produced fewer females per female per generation (Ro). As well as, lower rates of natural population increase per day (rm) compared to insects fed the control diet. Our findings indicated that, neem-derived products and growth-regulating insecticides of synthetic origin may be employed within integrated management strategies that aim to keep populations ofS. frugiperdabelow levels that cause economic damage. Similarly, they offer alternatives for insecticide resistance management programs.
Do primary and secondary host plants affect aphid- parasitoid interactions in fruit orchards?
Authors: Kök Şahin , Tomanović Željko , Karabacak Ersin , Kasap İsmail 
Published: December 2022

AbstractThe aim of this study was to investigate how the primary (PHP) and secondary host plants (SHP) in the fruit orchards affect the interactions of aphids and their parasitoids in northwest Turkey during spring and summer 2020 and 2021. In total, 67 tritrophic aphid–parasitoid-host plant interactions, including new association records for Europe and Turkey, were obtained from 16 parasitoid species from the subfamily Aphidiinae (Hymenoptera: Braconidae) reared from 25 aphid species (Hemiptera: Aphididae) on 22 PHP and SHP in the fruit orchards. Also, we evaluated the effect of the PHP and SHP on the parasitoids, aphids and their interactions. We revealed that the species richness and the values of the biodiversity indices of the parasitoids and aphids were significantly higher on the SHP than the PHP. Similarly, the aphid–parasitoid interactions on the SHP showed greater diversity than the PHP. The results of this study clearly show that the interactions of parasitoids and aphids in the fruit orchards were more diverse on the SHP compared to the PHP.
Friends Know Us Even When They Are Different From Us
Authors: Körner Robert , Schütz Astrid 
Published: December 2022

Abstract: Friendships pervade people’s social lives across their lifespans. But how accurately can friends perceive each other’s personalities? Person perceptions are typically a mixture of fact and fiction, but as friends share a lot of information, they should be able to form relatively accurate assessments. We referred to the truth and bias model of judgment to study accuracy in friendship dyads ( N = 190). Participants completed self- and peer-rating versions of the Big Five Inventory-10. Actor-partner interdependence models were used to decompose truth and bias forces: Friends achieved significant perceptual accuracy on each Big Five trait. Friends were actually rather similar in conscientiousness and also assumed they were similar to each other in this trait. For agreeableness, there was no actual but there was assumed similarity. There was neither actual nor assumed similarity for openness, extraversion, or neuroticism. Moreover, there was a considerable directional bias for all traits: Friends’ peer-ratings were positively biased: They assessed their friends as being more open, and conscientious, et cetera, than the friends did themselves. This research adds to the similarity-dissimilarity debate in social and personality psychology and the social perception literature in employing a sophisticated assessment of accuracy.
Drivers and Reversibility of Abrupt Ocean State Transitions in the Amundsen Sea, Antarctica
Authors: Caillet Justine , Jourdain Nicolas C. , Mathiot Pierre , Hellmer Hartmut H. , Mouginot Jérémie 
Published: December 2022

AbstractOcean warming around Antarctica has the potential to trigger marine ice‐sheet instabilities. It has been suggested that abrupt and irreversible cold‐to‐warm ocean tipping points may exist, with possible domino effect from ocean to ice‐sheet tipping points. A 1/4° ocean model configuration of the Amundsen Sea sector is used to investigate the existence of ocean tipping points, their drivers, and their potential impact on ice‐shelf basal melting. We apply idealized atmospheric perturbations of either heat, freshwater, or momentum fluxes, and we characterize the key physical processes at play in warm‐to‐cold and cold‐to‐warm climate transitions. Relatively weak perturbations of any of these fluxes are able to switch the Amundsen Sea to an intermittent or permanent cold state, that is, with ocean temperatures close to the surface freezing point and very low ice‐shelf melt rate. The transitions are reversible, that is, canceling the atmospheric perturbation brings the ocean system back to its unperturbed state within a few decades. All the transitions are primarily driven by changes in surface buoyancy fluxes resulting from the freshwater flux perturbation or from modified net sea‐ice production due to either heat flux or sea‐ice advection anomalies. These changes affect the vertical ocean stratification over the continental shelf and thereby the eastward undercurrent at the shelf break, which both impact ice‐shelf melting. As sea‐ice induced deep convection is already quite limited in present‐day conditions, surface buoyancy gain in a warmer climate has relatively little effect on deep ocean properties compared to colder climate conditions.
High-efficiency microwave-optical quantum transduction based on a cavity electro-optic superconducting system with long coherence time
Authors: Wang Changqing , Gonin Ivan , Grassellino Anna , Kazakov Sergey , Romanenko Alexander , Yakovlev Vyacheslav P. , Zorzetti Silvia 
Published: December 2022

AbstractFrequency conversion between microwave and optical photons is a key enabling technology to create links between superconducting quantum processors and to realize distributed quantum networks. We propose a microwave-optical transduction platform based on long-coherence time superconducting radio-frequency (SRF) cavities coupled to electro-optic optical cavities to mitigate the loss mechanisms that limit the attainment of high conversion efficiency. We optimize the microwave-optical field overlap and optical coupling losses in the design while achieving long microwave and optical photon lifetime at milli-Kelvin temperatures. This represents a significant enhancement of the transduction efficiency up to 50% under incoming pump power of 140 μW, which allows the conversion of few-photon quantum signals. Furthermore, this scheme exhibits high resolution for optically reading out the dispersive shift induced by a superconducting transmon qubit coupled to the SRF cavity. We also show that low microwave losses enhance the fidelity of heralded entanglement generation between two remote quantum systems. Finally, high precision in quantum sensing can be reached below the standard quantum limit.
ChAdOx1 NiV vaccination protects against lethal Nipah Bangladesh virus infection in African green monkeys
Authors: van Doremalen Neeltje , Avanzato Victoria A. , Goldin Kerry , Feldmann Friederike , Schulz Jonathan E. , Haddock Elaine , Okumura Atsushi , Lovaglio Jamie , Hanley Patrick W. , Cordova Kathleen , Saturday Greg , de Wit Emmie , Lambe Teresa , Gilbert Sarah C. , Munster Vincent J. 
Published: December 2022

AbstractNipah virus (NiV) is a highly pathogenic and re-emerging virus, which causes sporadic but severe infections in humans. Currently, no vaccines against NiV have been approved. We previously showed that ChAdOx1 NiV provides full protection against a lethal challenge with NiV Bangladesh (NiV-B) in hamsters. Here, we investigated the efficacy of ChAdOx1 NiV in the lethal African green monkey (AGM) NiV challenge model. AGMs were vaccinated either 4 weeks before challenge (prime vaccination), or 8 and 4 weeks before challenge with ChAdOx1 NiV (prime-boost vaccination). A robust humoral and cellular response was detected starting 14 days post-initial vaccination. Upon challenge, control animals displayed a variety of signs and had to be euthanized between 5 and 7 days post inoculation. In contrast, vaccinated animals showed no signs of disease, and we were unable to detect infectious virus in tissues and all but one swab. No to limited antibodies against fusion protein or nucleoprotein antigen could be detected 42 days post challenge, suggesting that vaccination induced a very robust protective immune response preventing extensive virus replication.
Risk-factor model for postpartum hemorrhage after cesarean delivery: a retrospective study based on 3498 patients
Authors: Gong Jun , Chen Zhi , Zhang Yi , Liu Yi-yun , Pu Jun-cai , Xiong Chun-yan , Gui Si-wen , He Xiao-ling , Wang Hui-lai , Zhong Xiao-gang 
Published: December 2022

AbstractThis study aimed to investigate the risk factors of patients with postpartum hemorrhage (PPH) after cesarean delivery (CD) and to develop a risk-factor model for PPH after CD. Patients were selected from seven affiliated medical institutions of Chongqing Medical University from January 1st, 2015, to January 1st, 2020. Continuous and categorical variables were obtained from the hospital’s electronic medical record systems. Independent risk factors were identified by univariate analysis, least absolute shrinkage and selection operator and logistic regression. Furthermore, logistic, extreme gradient boosting, random forest, classification and regression trees, as well as an artificial neural network, were used to build the risk-factor model. A total of 701 PPH cases after CD and 2797 cases of CD without PPH met the inclusion criteria. Univariate analysis screened 28 differential indices. Multi-variable analysis screened 10 risk factors, including placenta previa, gestational age, prothrombin time, thrombin time, fibrinogen, anemia before delivery, placenta accreta, uterine atony, placental abruption and pregnancy with uterine fibroids. Areas under the curve by random forest for the training and test sets were 0.957 and 0.893, respectively. The F1 scores in the random forest training and test sets were 0.708. In conclusion, the risk factors for PPH after CD were identified, and a relatively stable risk-factor model was built.
Item memorability has no influence on value-based decisions
Authors: Li Xinyue , Bainbridge Wilma A. , Bakkour Akram 
Published: December 2022

AbstractWhile making decisions, we often rely on past experiences to guide our choices. However, not all experiences are remembered equally well, and some elements of an experience are more memorable than others. Thus, the intrinsic memorability of past experiences may bias our decisions. Here, we hypothesized that individuals would tend to choose more memorable options than less memorable ones. We investigated the effect of item memorability on choice in two experiments. First, using food images, we found that the same items were consistently remembered, and others consistently forgotten, across participants. However, contrary to our hypothesis, we found that participants did not prefer or choose the more memorable over the less memorable items when choice options were matched for the individuals’ valuation of the items. Second, we replicated these findings in an alternate stimulus domain, using words that described the same food items. These findings suggest that stimulus memorability does not play a significant role in determining choice based on subjective value.
Semi-analytical solution for bottomhole pressure transient analysis of a hydraulically fractured horizontal well in a fracture-cavity reservoir
Authors: Hailong Liu 
Published: December 2022

AbstractThis paper study the role of hydraulic fracture properties on the transient bottomhole pressure (BHP) behavior of a horizontal well producing from a tight fracture-cavity reservoir. A combination of point source function, Laplace transformation and Perturbation transformation are used to obtain BHP step by step. Through literature comparison and numerical simulation, the results of BHP have a good consistency, which indicates the proposed method is scientific and reasonable. We divide the fluid flow into five stages, namely the wellbore storage stage, the karst cave fluid flows to the fracture stage, the radial flow stage of karst cave and fracture system, the matrix fluid flows to the fracture stage and the quasi-steady state stage. We come to the conclusion that the number of fractures and fracture direction mainly affect radial flow stage. In contrast, the length of horizontal subsection and skin factor mainly affect the karst cave fluid flows to the fracture stage. The matrix fluid flows to the fracture stage is more obvious when the fracture half-length and the horizontal segment spacing of the horizontal well are small. The study believes special attention should be paid to reforming the formations at both ends of the horizontal well. The advantage of this method is to incorporate well geometry (skin factor) and hydraulic fracturing design (fracture parameters), which is useful for well test interpretation through generating a new set of type curves. What’s more, this new method has the characteristics of easy calculation. The findings of this study can help for better understanding of well test analysis in fracture-cavity reservoir. However, the limitation of this study is that it is only suitable for this situation the horizontal well does not encounter karst caves and the karst caves in the reservoir are connected to the wellbore through fractures.
Chemistry, street canyon geometry, and emissions effects on NO2 “hotspots” and regulatory “wiggle room”
Authors: Dai Yuqing , Cai Xiaoming , Zhong Jian , MacKenzie A. Robert 
Published: December 2022

AbstractThe extent to which nitrogen dioxide (NO2) undergoes complex chemical-transport processes near strong nitrogen-oxide sources in street canyons is not fully understood. A multi-box framework with volatile organic compound (VOC) chemistry has been evaluated against large-eddy simulation (LES) data and observations, and then used to simulate NO2 at street-canyon “hotspots”. 42,000 sensitivity studies — varying nitrogen oxides (NOx) and VOC emission strength, and primary NO2 fraction ($$f_{{{{\mathrm{NO}}}}_2}$$

f

NO

2

) emitted within each of five streetscape cases — show the importance of detailed VOC chemistry, even in regular canyons (aspect ratio, AR = 1) when the ambient wind is weak. For a midsummer central London scenario, the inclusion of chemistry moves the canyon from compliance to out-of-compliance with the 1-hour NO2 standard. Ignoring street-canyon chemistry can lead, therefore, to false positives in regulatory air quality modelling. Neglecting VOC chemistry can underestimate NO2 by 6–22% in regular canyons, and even more (−51–31%) in deep canyons (AR = 2), particularly with lower $$f_{{{{\mathrm{NO}}}}_2}$$

f

NO

2

values resulting from gasoline-dominated vehicle fleets or by tighter control of primary NO2 from diesels. The very significant changes in regulatory “wiggle room” across sensitivity studies demonstrate the utility of this kind of chemistry-transport modelling for identifying efficient and effective regulatory pathways.
Reconstructing Mayotte 2018–19 Rift Valley Fever outbreak in humans by combining serological and surveillance data
Authors: Bastard Jonathan , Durand Guillaume André , Parenton Fanny , Hassani Youssouf , Dommergues Laure , Paireau Juliette , Hozé Nathanaël , Ruello Marc , Grard Gilda , Métras Raphaëlle , Noël Harold 
Published: December 2022

AbstractBackgroundRift Valley Fever (RVF) is a zoonosis that affects large parts of Africa and the Arabian Peninsula. RVF virus (RVFV) is transmitted to humans through contacts with infected animals, animal products, mosquito bites or aerosols. Its pathogenesis in humans ranges from asymptomatic forms to potentially deadly haemorrhagic fevers, and the true burden of human infections during outbreaks is generally unknown.MethodsWe build a model fitted to both passive surveillance data and serological data collected throughout a RVF epidemic that occurred in Mayotte Island in 2018–2019.ResultsWe estimate that RVFV infected 10,797 (95% CrI 4,728–16,127) people aged ≥15 years old in Mayotte during the entire outbreak, among which only 1.2% (0.67%–2.2%) were reported to the syndromic surveillance system. RVFV IgG seroprevalence in people ≥15 years old was estimated to increase from 5.5% (3.6%–7.7%) before the outbreak to 12.9% (10.4%–16.3%) thereafter.ConclusionsOur results suggest that a large part of RVFV infected people present subclinical forms of the disease and/or do not reach medical care that could lead to their detection by the surveillance system. This may threaten the implementation of exhaustive RVF surveillance and adequate control programs in affected countries.
An evolution towards scientific consensus for a sustainable ocean future
Authors: Gaill Françoise , Brodie Rudolph Tanya , Lebleu Lara , Allemand Denis , Blasiak Robert , Cheung William W. L. , Claudet Joachim , Gerhardinger Leopoldo Cavaleri , Le Bris Nadine , Levin Lisa , Pörtner Hans- Otto , Visbeck Martin , Zivian Anna , Bahurel Pierre , Bopp Laurent , Bowler Chris , Chlous Frédérique , Cury Philippe , Gascuel Didier , Goyet Sylvie , Hilmi Nathalie , Ménard Frédéric , Micheli Fiorenza , Mullineaux Lauren , Parmentier Rémi , Sicre Marie-Alexandrine , Speich Sabrina , Thébaud Olivier , Thiele Torsten , Bowler Martha , Charvis Philippe , Cuvelier Raphael , Houllier François , Palazot Sarah , Staub Francis , Poivre d’Arvor Olivier 
Published: December 2022

AbstractThe ocean has recently taken centre stage in the global geopolitical landscape. Despite rising challenges to the effectiveness of multilateralism, attention to ocean issues appears as an opportunity to co-create pathways to ocean sustainability at multiple levels. The ocean science community, however, is not sufficiently well organised to advance these pathways and provide policy input. The Intergovernmental Panel on Climate Change and the Intergovernmental Science-Policy Platform on Biodiversity and Ecosystem Services demonstrate how knowledge consensus and integration have been instrumental in charting global pathways and eliciting commitments to address, respectively, climate change and biodiversity loss. An equally impactful global platform with a thematic focus on ocean sustainability is needed. Here we introduce the International Panel for Ocean Sustainability (IPOS) as a coordinating mechanism to integrate knowledge systems to forge a bridge across ocean science-policy divides collectively. The IPOS will enrich the global policy debate in the Ocean Decade and support a shift toward ocean sustainability.
Novel preventive effect of isorhamnetin on electrical and structural remodeling in atrial fibrillation
Authors: Aonuma Kazuhiro , Xu DongZhu , Murakoshi Nobuyuki , Tajiri Kazuko , Okabe Yuta , Yuan Zixun , Li Siqi , Murakata Yoshiko , Tominaga Kenichi , Nogami Akihiko , Aonuma Kazutaka , Ieda Masaki , Isoda Hiroko 
Published: December 2022

Abstract
Isorhamnetin, a natural flavonoid, has strong antioxidant and antifibrotic effects, and a regulatory effect against Ca2+-handling. Atrial remodeling due to fibrosis and abnormal intracellular Ca2+ activities contributes to initiation and persistence of atrial fibrillation (AF). The present study investigated the effect of isorhamnetin on angiotensin II (AngII)-induced AF in mice. Wild-type male mice (C57BL/6J, 8 weeks old) were assigned to three groups: (1) control group, (2) AngII-treated group, and (3) AngII- and isorhamnetin-treated group. AngII (1000 ng/kg/min) and isorhamnetin (5 mg/kg) were administered continuously via an implantable osmotic pump for two weeks and intraperitoneally one week before initiating AngII administration, respectively. AF induction and electrophysiological studies, Ca2+ imaging with isolated atrial myocytes and HL-1 cells, and action potential duration (APD) measurements using atrial tissue and HL-1 cells were performed. AF-related molecule expression was assessed and histopathological examination was performed. Isorhamnetin decreased AF inducibility compared with the AngII group and restored AngII-induced atrial effective refractory period prolongation. Isorhamnetin eliminated abnormal diastolic intracellular Ca2+ activities induced by AngII. Isorhamnetin also abrogated AngII-induced APD prolongation and abnormal Ca2+ loading in HL-1 cells. Furthermore, isorhamnetin strongly attenuated AngII-induced left atrial enlargement and atrial fibrosis. AngII-induced elevated expression of AF-associated molecules, such as ox-CaMKII, p-RyR2, p-JNK, p-ERK, and TRPC3/6, was improved by isorhamnetin treatment. The findings of the present study suggest that isorhamnetin prevents AngII-induced AF vulnerability and arrhythmogenic atrial remodeling, highlighting its therapeutic potential as an anti-arrhythmogenic pharmaceutical or dietary supplement.