bluuebunny/crossref_metadata_2025_split huggingface dataset:
Paradoxical consequences of wastewater interventions targeting carbapenemase-producing Enterobacterales
Authors: Lehman David , Kotay Shireen , Parikh Hardik , Park Stacy , Mathers Amy 
Published: September 2023

Background:Serratia marcescens is a leading cause of hospital-acquired infections. There has been increasing recognition of hospital wastewater as a reservoir for carbapenemase-producing Enterobacterales (CPE), including S. marcescens. Because CPE can proliferate in biofilms in sink drains and traps, controlling nosocomial spread is challenging. The ideal approach to eliminate transmission from wastewater to patients remains unknown. Methods: Patients were included if they were admitted to 1 of 2 intensive care units (ICUs) for >12 hours between December 1, 2010, and January 31, 2016. During this period at the University of Virginia Hospital, there was ongoing patient acquisition of multiple species producing Klebsiella pneumoniae carbapenemase (KPC) as well as consistent perirectal KPC surveillance. In January 2014, to eliminate CPE-colonized sinks, the sink drains and traps in one of the ICUs (ie, the “intervention unit”) were exchanged followed by varied chemical mitigations to prevent recolonization. In another ICU, the same chemical mitigations were performed but without plumbing replacement (ie, the “control unit”). Acquisition of KPC-producing S. marcescens was defined as colonization or infection >12 hours after admission to either unit. To control for increases in patient-to-patient transmission, acquisition of methicillin-resistant Staphylococcus aureus (MRSA) was evaluated in the intervention unit during the same period and was defined as new colonization or infection with MRSA >12 hours after unit admission but within 21 days of last unit exposure. Results: For the postintervention period, risk of S. marcescens acquisition was increased (RR, 2.85; 95% CI, 1.24–6.58; P = .01) in the intervention unit compared to the control unit. In the intervention unit, the risk of S. marcescens acquisition increased in the postintervention period compared to the preintervention period (RR, 6.26; 95% CI, 2.59–15.1; P < .0001). There was no change in MRSA acquisition in the intervention unit representing consistent patient-to-patient infection prevention (RR, 0.95; 95% CI, 0.61–1.48; P = .81). S. marcescens isolates were noted to be highly clonal. Conclusions: Exposure to the intervention unit following plumbing replacement was associated with increased relative risk of acquisition of KPC-producing S. marcescens. This increased risk was not observed in the control unit, which had only chemical plumbing interventions. There was no concomitant increase in patient-to-patient MRSA transmission. The disturbance of the wastewater environment through the plumbing replacement intervention may have led to the unintended consequence of more KPC-producing S. marcescens acquisition.Disclosures: None
Electronic phenotyping of community-acquired pneumonia: A tool for inpatient syndrome-specific antimicrobial stewardship
Authors: Chang Amy , Bui Annie , Ha David , Alegria William , Holubar Marisa , Lu Brian , Mische Leah , Linfield Rebecca , Walding Kyle , Mui Emily 
Published: September 2023

Background: Using patient data from the electronic health record (EHR) and computer logic, an “electronic phenotype” can be created to identify patients with community-acquired pneumonia (CAP) in real time to assist with syndrome-specific antimicrobial stewardship efforts.1 We adapted and validated the performance of an inpatient CAP electronic phenotype for antimicrobial stewardship interventions. Methods: An automated scoring system was created within the EHR (Epic Systems) to identify hospitalized patients with CAP based on the variables and logic listed in Fig. 1B. We adapted a score used by the Michigan Hospital Medicine Safety Consortium (HMS) to identify patients with CAP, with additions made to improve sensitivity (Fig. 1).1 The score can be displayed in a column within the EHR patient list (Fig. 2). We validated the electronic phenotype via chart review of all hospitalized patients on systemic antimicrobials admitted to a medicine team consecutively between November 8 and 18, 2021. Patients who were readmitted within the validation time frame were excluded. We assessed the performance of the electronic phenotype by comparing the score to manual chart review, where “CAP diagnosis” was defined as (1) mention of “pneumonia” or “CAP” as part of the differential diagnosis in the admission documentation, (2) antimicrobials were started within 48 hours of admission, and (3) radiographic findings were suggestive of pneumonia. After initial evaluation, the scoring system was adjusted, and performance was re-evaluated during prospective audit and feedback performed on EHR CAP–positive patients over 13 days between July 2022 and December 2022. Results: We included 191 patients in our initial validation cohort. The CAP score had high sensitivity (95.83%), specificity (92.2%), and negative predictive value (99.35%), though lower positive predictive value (63.89%) was noted (Table 2). The rules were further refined to include bloodstream infection only with Haemophilus influenza or Streptococcus pneumoniae in rule 2B, and azithromycin was removed from “CAP antibiotics.” After these changes, repeated evaluation of 88 patients with positive CAP EHR score was performed, and only 20 (23%) were considered false-positive results. Conclusions: Electronic phenotypes can be used to create automated tools to identify patients with CAP with reasonable performance. Data from this tool can be used to guide more focused antimicrobial stewardship interventions and clinical decision support in the future. Reference: Vaughn VM, et al. A statewide collaborative quality initiative to improve antibiotic duration and outcomes in patients hospitalized with uncomplicated community-acquired pneumonia. Clin Infect Dis 2022;75:460–467.Disclosures: None
Non-invasive assessment of positive affective state using infra-red thermography in rats
Authors: Wongsaengchan Chanakarn , McCafferty Dominic J , Lennox Katie , Nager Ruedi G , McKeegan Dorothy EF 
Published: September 2023

Abstract
With recent increased focus on positive welfare in animal welfare science, there is demand for objective positive welfare indicators. It is unclear whether changes in body surface temperature can be used to non-invasively identify and quantify positive states in mammals. We recorded continuous measurements of tail surface temperature using infra-red thermography (IRT) and concurrent behavioural observations in male and female Wistar rats (Rattus norvegicus). If tail surface temperature can differentiate between positive and negative experiences, we expect a qualitatively different response compared to negative experiences. Three groups of rats were presented with increasing magnitudes of food rewards (neutral/none, one and three rewards). The rats were placed in an arena to which they were habituated and filmed for 30 s before and 30 min after exposure to different rewards. Tail temperature initially decreased from the pre-reward baseline and subsequently returned towards baseline temperature. The overall pattern of the change was the same as for rats subjected to negative stimuli in previous studies. Nevertheless, dynamic changes in tail temperature, specifically the rate of recovery and the behavioural response (exploration), differed between neutral and rewarded rats but failed to distinguish reward magnitude. Sex differences were found in both thermal and behavioural responses, unrelated to reward magnitudes. Female rats exhibited a greater initial response with a slower recovery than male rats, emphasising the value of using of both sexes in animal welfare research. This study improves our understanding of the effects of positive emotions induced by food reward on peripheral body temperature and behaviour.
Cooperation and group similarity in children and young adults in the UK
Authors: Majolo Bonaventura , Maréchal Laëtitia , Igali Ferenc , Van de Vyver Julie 
Published: September 2023

AbstractFor cooperation to be beneficial, cooperators should be able to differentiate individuals who are willing to cooperate from free-riders. In the absence of kin or of familiar individuals, phenotypic similarity (e.g. in terms of language) can be used as a cue of how likely two or more individuals are to behave similarly (whether they will cooperate or free-ride). Thus, phenotypic similarity could affect cooperation. However, it is unclear whether humans respond to any type of phenotypic similarity or whether only salient phenotypic traits guide cooperation. We tested whether within-group, non-salient phenotypic similarity affects cooperation in 280, 3 to 10 year old children and in 76 young adults (mean 19.8 years old) in the UK. We experimentally manipulated the degree of phenotypic similarity in three computer-based experiments. We found no evidence of a preference for, or greater cooperation with, phenotypically similar individuals in children, even though children displayed ingroup preference. Conversely, young adults cooperated more with phenotypically similar than with phenotypically diverse individuals to themselves. Our results suggest that response to non-salient phenotypic similarity varies with age and that young adults may pay more attention to non-salient cues of diversity then children.
Employer associations in light of the Great Recession and radical labour market deregulation in Southern Europe: An analysis from the perspective of company membership
Authors: Sánchez-Mosquera Marcial 
Published: September 2023

AbstractThis article analyses the impact of the Great Recession and radical labour market deregulation on employer associations’ (EAs) membership levels and composition in Southern Europe. It also reviews the literature and advances it in four relevant aspects. First, it verifies a general decrease in membership of EAs in Southern Europe, almost to the point of collapse in Greece. Secondly, it identifies the greater importance of large companies (more than Fordist economic sectors) in the composition of this membership. Thirdly, it confirms that sectoral bargaining (as a major determinant) and union representation (an element weakened by reforms) are strong company-level incentives for membership in EAs. Finally, it re-examines the reasons put forward in the scholarly literature to explain why EAs in Southern Europe have not been in favour of these significant institutional changes.
Big Banks, Household Credit Access, and Intergenerational Economic Mobility
Authors: Mayer Erik J. 
Published: September 2023

AbstractConsolidation in the U.S. banking industry has led to larger banks. I find that low-income households face reduced access to credit when local banks are large. This result appears to stem from large banks’ comparative disadvantage using soft information, which is particularly important for lending to low-income households. In contrast, the size of local banks has little or no effect on high-income households. Consistent with low-income parents’ credit constraints limiting investment in their children’s human capital, areas with larger banks exhibit a greater sensitivity of educational attainment to parental income, and less intergenerational economic mobility.
Russia’s Arctic policy: Upcoming change?
Authors: Staun Jørgen 
Published: September 2023

Abstract
Russia’s Arctic policy since 2008 has been influenced by two competing foreign policy lines (discourses): the “Arctic as a resource base” and the “sovereignty discourse”. The “Arctic as a resource base” has been the dominant one since the first Russian Arctic Strategy in 2008. It is primarily about exploiting the vast oil and gas resources estimated to be located there, as well as turn the Northern Sea Route into a “global transport corridor”. In Russia’s Arctic Strategy of 2020, however, there is enhanced emphasis on sovereignty and power balancing in Russian Arctic policy. And the focus on sovereignty was heightened with the amendments to Russia’s Arctic Strategy in March 2023. This increased emphasis on sovereignty, territorial defence and balance of power in Russian Arctic policy is likely to be further reinforced by the growing great-power competition between the USA and Russia, which has gained new momentum following Russia’s invasion of Ukraine in 2022.
Infant epigenetic aging moderates the link between Black maternal childhood trauma and offspring symptoms of psychopathology
Authors: McKenna Brooke G. , Knight Anna K. , Smith Alicia K. , Corwin Elizabeth J. , Carter Sierra E. , Palmer Rohan H.C. , Dunlop Anne L. , Brennan Patricia A. 
Published: September 2023

AbstractAlthough offspring of women exposed to childhood trauma exhibit elevated rates of psychopathology, many children demonstrate resilience to these intergenerational impacts. Among the variety of factors that likely contribute to resilience, epigenetic processes have been suggested to play an important role. The current study used a prospective design to test the novel hypothesis that offspring epigenetic aging – a measure of methylation differences that are associated with infant health outcomes – moderates the relationship between maternal exposure to childhood adversity and offspring symptomatology. Maternal childhood adversity was self-reported during pregnancy via the ACEs survey and the CTQ, which assessed total childhood trauma as well as maltreatment subtypes (i.e., emotional, physical, and sexual abuse). Offspring blood samples were collected at or shortly after birth and assayed on a DNA methylation microarray, and offspring symptomatology was assessed with the CBCL/1.5–5 when offspring were 2–4 years old. Results indicated that maternal childhood trauma, particularly sexual abuse, was predictive of offspring symptoms (ps = 0.003–0.03). However, the associations between maternal sexual abuse and offspring symptomatology were significantly attenuated in offspring with accelerated epigenetic aging. These findings further our understanding of how epigenetic processes may contribute to and attenuate the intergenerational link between stress and psychopathology.
Do shape and size matter? The distribution ofAmphore Crétoise4 containers, 1st–3rd c. CE
Authors: Gallimore Scott 
Published: September 2023

AbstractThis paper examines the distinctive distribution patterns ofAmphore Crétoise(AC) 4 amphoras within Roman trade networks through critical assessment of the morphological attributes of this amphora type compared to AC1–3 jars and through consideration of the mechanisms that underlie these patterns. This builds on a growing number of studies that have focused on the design attributes of amphoras as important factors tied to their economic role. It also demonstrates the importance of engaging in more nuanced and detailed investigations that question assumptions about amphora distribution within the Roman world. The AC4 is the primary, and often only, Cretan type found at sites in Rome's northwestern provinces and along the Danube frontier. A narrower profile and smaller capacity appear to have made this amphora type more attractive than other Cretan forms for transport along river and overland routes.
Domains and Psychometric Properties of Scales Measuring Disaster Preparedness among General Population: A Systematic Literature Review
Authors: Osman Marwa , Altıntaş Kerim Hakan 
Published: September 2023

AbstractIntroduction:There is no universal tool for measuring disaster preparedness in the general population. This study aimed to provide a summary of the domains and psychometric properties of the available scales that assess preparedness for disasters, or one of its main types, among individuals or households.Methods:This study is a systematic review of the literature on disaster preparedness tools. Studies published up to December 2022 were identified through a systematic search of four databases: Google Scholar, PubMed, Scopus, and Web of Science. Consensus-Based Standards for the Selection of Health Measurement Instruments (COSMIN) were used to review and evaluate the psychometric properties. The Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) guidelines were used to report this article.Results:Twelve articles met the inclusion criteria. Among them, five scales measured general disaster preparedness, five measured earthquake preparedness, one measured flood preparedness, and one measured bushfire preparedness. The scales had a number of dimensions ranging from one to six. The most common item topics in the included scales were as follows: having an evacuation plan (n = 7), information source (n = 7), fire extinguisher (n = 6), and emergency kit (n = 5). The scales were rated sufficient for content validity (n = 10), structural validity (n = 5), internal consistency (n = 5), and test-re-test reliability (n = 6). One scale was checked for criterion validity and was rated as insufficient according to the COSMIN guidelines.Conclusion:The findings suggest the need to improve the psychometric properties of the scales, expand their contents, and develop scales relevant to target populations. This study provides useful information for researchers to develop comprehensive assessment tools and valuable sources of items for future scales.
The Promise and Limits of Grounding in Law
Authors: Tripkovic Bosko , Patterson Dennis 
Published: September 2023

AbstractDiscussions of metaphysical grounding have recently found their way into general jurisprudence. It is becoming increasingly common to frame the debate between positivism and antipositivism as a disagreement about what facts metaphysically ground legal facts. In this article we critically evaluate this grounding turn. First, we argue that articulating the debate about the nature of law in terms of grounding holds the promise of recasting it in a common vocabulary. Second, we argue that this comes at a cost: framing the debate in this way obscures a range of further disagreements that cannot be usefully analyzed in terms of metaphysical grounding. We conclude that grounding may give us a clearer picture of what we already knew, while obfuscating a number of important questions to which it cannot, and is not intended to, provide answers.
What do we know about religion and interreligious peace? A review of the quantitative literature
Authors: Köbrich Julia , Hoffmann Lisa 
Published: September 2023

AbstractInterreligious relations remain an important dimension of human coexistence and we currently observe an increase in religiously motivated violence and discrimination. Hence, we need to better understand determinants of interreligious peace. Building on a new concept of interreligious peace which includes but exceeds the absence of interreligious physical violence, we provide a systematic review of 83 quantitative empirical studies examining religious determinants of interreligious physical violence, hostile attitudes, threat perceptions, trust, and cooperation. We find that religious ideas foster or hinder interreligious peace depending on their content. Religious identities have negative effects but must be considered in context. Evidence regarding the role of religious practice is mixed and the role of religious actors and institutions remains understudied. Our results show the need for (1) more conceptual clarity, (2) replications in different contexts, (3) research on dimensions of religion beyond identities, and (4) a better integration of different strands of literature.
Simultaneous Global Ionospheric Disturbances Associated With Penetration Electric Fields During Intense and Minor Solar and Geomagnetic Disturbances
Authors: Zhang Shun‐Rong , Nishimura Yukitoshi , Vierinen Juha , Lyons Larry R. , Knipp Delores J. , Gustavsson Björn J. , Waghule Bhagyashree V. , Erickson Philip J. , Coster Anthea J. , Aa Ercha , Spicher Andres 
Published: September 2023

AbstractA new observational phenomenon, named Simultaneous Global Ionospheric Density Disturbance (SGD), is identified in GNSS total electron content (TEC) data during periods of three typical geospace disturbances: a Coronal Mass Ejection‐driven severe disturbance event, a high‐speed stream event, and a minor disturbance day with a maximum Kp of 4. SGDs occur frequently on dayside and dawn sectors, with a ∼1% TEC increase. Notably, SGDs can occur under minor solar‐geomagnetic disturbances. SGDs are likely caused by penetration electric fields (PEFs) of solar‐geomagnetic origin, as they are associated with Bz southward, increased auroral AL/AU, and solar wind pressure enhancements. These findings offer new insights into the nature of PEFs and their ionospheric impact while confirming some key earlier results obtained through alternative methods. Importantly, the accessibility of extensive GNSS networks, with at least 6,000 globally distributed receivers for ionospheric research, means that rich PEF information can be acquired, offering researchers numerous opportunities to investigate geospace electrodynamics.
Dominant Cloud Controlling Factors for Low‐Level Cloud Fraction: Subtropical Versus Extratropical Oceans
Authors: Naud Catherine M. , Elsaesser Gregory S. , Booth James F. 
Published: September 2023

AbstractTo improve cloud feedback understanding and simulation, observations have been used to quantify the rate of change of cloud radiative properties as a function of specific environmental metrics (or cloud controlling factors; CCFs). The study focuses on low‐level cloud dominated regions during 2006–2010. For each ocean gridpoint, Spearman's rank correlation coefficients of daily mean observed cloud fraction versus (a) 10‐m wind, (b) sensible heat flux (SHF), (c) sea surface temperature, (d) estimated inversion strength (EIS), (e) 850 hPa vertical velocity, and (f) the M parameter () are sorted to identify the dominant CCFs in both extratropics (30°–60°N/S) and subtropics (30°S–30°N). A novel map for visualizing dominant CCFs for low‐level cloud fraction reveals that: dominates in the subtropical stratocumulus regions while 10‐m winds dominate in shallow cumulus regions but in the extratropics, a different inversion structure diagnostic (EIS) dominates, while SHF dominates in western boundary current areas.
The Stepwise Reduction of Multiyear Sea Ice Area in the Arctic Ocean Since 1980
Authors: Babb D. G. , Galley R. J. , Kirillov S. , Landy J. C. , Howell S. E. L. , Stroeve J. C. , Meier W. , Ehn J. K. , Barber D. G. 
Published: September 2023

AbstractThe loss of multiyear sea ice (MYI) in the Arctic Ocean is a significant change that affects all facets of the Arctic environment. Using a Lagrangian ice age product, we examine MYI loss and quantify the annual MYI area budget from 1980 to 2021 as the balance of export, melt, and replenishment. Overall, MYI area declined at 72,500 km2/yr; however, a majority of the loss occurred during two stepwise reductions that interrupt an otherwise balanced budget and resulted in the northward contraction of the MYI pack. First, in 1989, a change in atmospheric forcing led to a +56% anomaly in MYI export through Fram Strait. The second occurred from 2006 to 2008 with anomalously high melt (+25%) and export (+23%) coupled with low replenishment (−8%). In terms of trends, melt has increased since 1989, particularly in the Beaufort Sea, export has decreased since 2008 due to reduced MYI coverage north of Fram Strait, and replenishment has increased over the full time series due to a negative feedback that promotes seasonal ice survival at higher latitudes exposed by MYI loss. However, retention of older MYI has significantly declined, transitioning the MYI pack toward younger MYI that is less resilient than previously anticipated and could soon elicit another stepwise reduction. We speculate that future MYI loss will be driven by increased melt and reduced replenishment, both of which are enhanced with continued warming and will one day render the Arctic Ocean free of MYI, a change that will coincide with a seasonally ice‐free Arctic Ocean.