bluuebunny/crossref_metadata_2025_split huggingface dataset:
Huge mucinous cystic neoplasms with adhesion to the left colon: A case report and literature review
Authors: Tang Haijun , Shen Zhihong , Lu Baochun 
Published: January 2023

Abstract
Mucinous cystic neoplasms (MCN) are rare premalignant neoplasms of the pancreas typically found as single lesions in the pancreatic body and tail of women in the fifth and sixth decade of life, constituting 2–5% of pancreatic neoplasms. We present a 50-year-old female patient with a large tail mass of the pancreatic body (size of 15 cm × 12 cm) with elevated tumor indicators. Computed tomography and magnetic resonance imaging revealed a large cystic lesion with septa and wall nodules. During the operation, the tumor capsule wall adhered to the left half colon and mesentery and could not be detached. Splenectomy and left hemicolectomy were performed. The postoperative pathological examination of the specimens confirmed a premalignant pancreatic mucous cystic tumor with moderate heterocytosis. The preoperative diagnosis of pancreatic MCN and MCN with invasive carcinoma is discussed, considering the characteristics of this case. Age, tumor size, texture, tumor marker elevation, and cystic wall condition are important characteristics of malignant MCN. Nevertheless, it is still very difficult to determine accurately whether an MCN is malignant or not before an actual pathological examination of the resected specimen.
Exploring the experiences of international Chinese students at a UK university: a qualitative inquiry
Authors: Holliman Andrew J. , Bastaman Amanda S. , Wu Hiu S. , Xu Shuyue , Waldeck Daniel 
Published: January 2023

Abstract
The largest group of international students pursuing their overseas higher education in the UK come from China; and yet, little qualitative research has explored the experiences of Chinese students who have recently made this transition, with even less focusing on the experiences of both undergraduate and postgraduate students. The present article set out to explore the unique perspective of a small sample of first-year undergraduate and first-year postgraduate students (N = 18), on their experience of transitioning to a higher education institution in the UK. Semi-structured interviews were conducted, and thematic analysis was used to explore their experiences in greater depth. Two superordinate themes are reported here: “Education Dialogues and Scholarship” and “Intercultural Relations and Notions of Difference.” The findings suggest that despite advances in institutional practices to support international students’ transition to higher education in the UK, more work needs to be done to redress the sociocultural (and other) challenges that continue to exist for international Chinese students.
Welfare States and Covid-19 Responses: Eastern versus Western Democracies
Authors: Nikolova Kristina , Bejan Raluca 
Published: January 2023

Abstract
This study uses a welfare state lens to examine disparities in Covid-19 infections and mortality rates between countries in Eastern Europe compared to West European democracies. Expanding on Esping-Andersen’s typology of welfare regimes, the authors compare six country groups to conduct a multivariate statistical analysis that, when controlling for economic and health differences, shows the number of cases and deaths per 100,000 to be significantly higher for Eastern Europe. In comparing First, Second, and Third Wave data, the difference in Covid-19 infections and mortality rates can be explained through stricter lockdown measures implemented in the East at the start of the First Wave. Overall higher numbers in the East reflect comparatively looser state measures in response to the Second and Third Waves as well as the lack of trust in government and the weak implementation of public health measures.
The Franciscan Order of Things: Empire, Community, and Archival Practices in the Monasteries of Ottoman Bosnia
Authors: Sekulić Ana 
Published: January 2023

Abstract
This article revisits the history of the Franciscan archives under Ottoman rule by focusing on archival documents, practices, and spaces in the Monastery of the Holy Spirit in Fojnica. Ottoman papers and archives preserved in the Franciscan spaces were often associated with Ottoman oppression. In this study, the author demonstrates that the documentary relationship between monasteries and Ottoman chanceries was not one-directional and cannot be characterized as oppressive. Franciscans actively engaged with the Ottoman documents and genres; they relied on the Ottoman vocabularies and legitimacy embedded in the documents, and subverted them at the same time, carving out their own physical and discursive spaces, which were tied to and yet different from the imaginaries of the Ottoman imperial order. The article emphasizes how examining archival narratives is located at the intersection of practices, texts, and spaces.
Side Effects of “Phantom Pains”: How Bulgarian Historical Mythology Derails North Macedonia’s EU Accession
Authors: Brunnbauer Ulf 
Published: January 2023

Abstract
What happens if historical daydreams derail the vector of European integration? The latest round in the dispute between Bulgaria and North Macedonia provides an insight. This analysis discusses Bulgaria’s veto on European Union (EU) accession talks with North Macedonia, first declared in 2019, and its manifold consequences. Bulgaria tied its consent to North Macedonia’s accession to the EU with the country first capitulating to Bulgarian demands concerning its history and identity. This revived arguments from the 1960s and 1970s. Bulgaria’s demands led to a nationalist counter-reaction in North Macedonia, while at the same time complicating the work of a joint expert commission on shared history established in 2017. The author highlights the unenviable nature of the position of the Macedonian members in the commission, caught as they are between their academic ethos and the diplomatic priorities of their country. The analysis concludes with remarks on the implications for the EU of Bulgaria’s “phantom pains” over Macedonia.
NMDA Receptor Activation-Dependent Antidepressant-Relevant Behavioral and Synaptic Actions of Ketamine
Authors: Zanos Panos , Brown Kyle A. , Georgiou Polymnia , Yuan Peixiong , Zarate Carlos A. , Thompson Scott M. , Gould Todd D. 
Published: January 2023

Ketamine is a well-characterized NMDA receptor (NMDAR) antagonist, although the relevance of this pharmacology to its rapid (within hours of administration) antidepressant actions, which depend on mechanisms convergent with strengthening of excitatory synapses, is unclear. Activation of synaptic NMDARs is necessary for the induction of canonical long-term potentiation (LTP) leading to a sustained expression of increased synaptic strength. We tested the hypothesis that induction of rapid antidepressant effects requires NMDAR activation, by using behavioral pharmacology, western blot quantification of hippocampal synaptoneurosomal protein levels, andex vivohippocampal slice electrophysiology in male mice. We found that ketamine exerts an inverted U-shaped dose-response in antidepressant-sensitive behavioral tests, suggesting that an excessive NMDAR inhibition can prevent ketamine's antidepressant effects. Ketamine's actions to induce antidepressant-like behavioral effects, up-regulation of hippocampal AMPAR subunits GluA1 and GluA2, as well as metaplasticity measuredex vivousing electrically-stimulated LTP, were abolished by pretreatment with other non-antidepressant NMDAR antagonists, including MK-801 and CPP. Similarly, the antidepressant-like actions of other putative rapid-acting antidepressant drugs (2R,6R)-hydroxynorketamine (ketamine metabolite), MRK-016 (GABAAα5 negative allosteric modulator), and LY341495 (mGlu2/3receptor antagonist) were blocked by NMDAR inhibition. Ketamine acted synergistically with an NMDAR positive allosteric modulator to exert antidepressant-like behavioral effects and activation of the NMDAR subunit GluN2A was necessary and sufficient for such relevant effects. We conclude rapid-acting antidepressant compounds share a common downstream NMDAR-activation dependent effector mechanism, despite variation in initial pharmacological targets. Promoting NMDAR signaling or other approaches that enhance NMDAR-dependent LTP-like synaptic potentiation may be an effective antidepressant strategy.SIGNIFICANCE STATEMENTThe anesthetic and antidepressant drug ketamine is well-characterized as an NMDA receptor (NMDAR) antagonist; though, the relevance and full impact of this pharmacology to its antidepressant actions is unclear. We found that NMDAR activation, which occurs downstream of their initial actions, is necessary for the beneficial effects of ketamine and several other putative antidepressant compounds. As such, promoting NMDAR signaling, or other approaches that enhance NMDAR-dependent long-term potentiation (LTP)-like synaptic potentiationin vivomay be an effective antidepressant strategy directly, or acting synergistically with other drug or interventional treatments.
Enhanced Reactivation of Remapping Place Cells during Aversive Learning
Authors: Ormond Jake , Serka Simon A. , Johansen Joshua P. 
Published: January 2023

Study of the hippocampal place cell system has greatly enhanced our understanding of memory encoding for distinct places, but how episodic memories for distinct experiences occurring within familiar environments are encoded is less clear. We developed a spatial decision-making task in which male rats learned to navigate a multiarm maze to a goal location for food reward while avoiding maze arms in which aversive stimuli were delivered. Task learning induced partial remapping in CA1 place cells, allowing us to identify both remapping and stable cell populations. Remapping cells were recruited into sharp-wave ripples and associated replay events to a greater extent than stable cells, despite having similar firing rates during navigation of the maze. Our results suggest that recruitment into replay events may be a mechanism to incorporate new contextual information into a previously formed and stabilized spatial representation.SIGNIFICANCE STATEMENTHippocampal place cells provide a map of space that animals use to navigate. This map can change to reflect changes in the physical properties of the environment in which the animal finds itself, and also in response to nonphysical contextual changes, such as changes in the valence of specific locations within that environment. We show here that cells which change their spatial tuning after a change in context are preferentially recruited into sharp-wave ripple-associated replay events compared with stable nonremapping cells. Thus, our data lend strong support to the hypothesis that replay is a mechanism for the storage of new spatial maps.
fmr1Mutation Alters the Early Development of Sensory Coding and Hunting and Social Behaviors in Larval Zebrafish
Authors: Zhu Shuyu I. , McCullough Michael H. , Pujic Zac , Sibberas Jordan , Sun Biao , Darveniza Thomas , Bucknall Bianca , Avitan Lilach , Goodhill Geoffrey J. 
Published: January 2023

Autism spectrum disorders (ASDs) are developmental in origin; however, little is known about how they affect the early development of behavior and sensory coding. The most common inherited form of autism is Fragile X syndrome (FXS), caused by a mutation inFMR1. Mutation offmr1in zebrafish causes anxiety-like behavior, hyperactivity, and hypersensitivity in auditory and visual processing. Here, we show that zebrafishfmr1−/− mutant larvae of either sex also display changes in hunting behavior, tectal coding, and social interaction. During hunting, they were less successful at catching prey and displayed altered behavioral sequences. In the tectum, representations of prey-like stimuli were more diffuse and had higher dimensionality. In a social behavioral assay, they spent more time observing a conspecific but responded more slowly to social cues. However, when given a choice of rearing environmentfmr1−/− larvae preferred one with reduced visual stimulation, and rearing them in this environment reduced genotype-specific effects on tectal excitability. Together, these results shed new light on howfmr1−/− changes the early development of neural systems and behavior in a vertebrate.SIGNIFICANCE STATEMENTAutism spectrum disorders (ASDs) are caused by changes in early neural development. Animal models of ASDs offer the opportunity to study these developmental processes in greater detail than in humans. Here, we found that a zebrafish mutant for a gene which in humans causes one type of ASD showed early alterations in hunting behavior, social behavior, and how visual stimuli are represented in the brain. However, we also found that mutant fish preferred reduced visual stimulation, and rearing them in this environment reduced alterations in neural activity patterns. These results suggest interesting new directions for using zebrafish as a model to study the development of brain and behavior in ASDs, and how the impact of ASDs could potentially be reduced.
Plasma membrane topography governs the 3D dynamic localization of IgM B cell antigen receptor clusters
Authors: Saltukoglu Deniz , Özdemir Bugra , Holtmannspötter Michael , Reski Ralf , Piehler Jacob , Kurre Rainer , Reth Michael 
Published: January 2023

AbstractB lymphocytes recognize bacterial or viral antigens via different classes of the B cell antigen receptor (BCR). Protrusive structures termed microvilli cover lymphocyte surfaces, and are thought to perform sensory functions in screening antigen‐bearing surfaces. Here, we have used lattice light‐sheet microscopy in combination with tailored custom‐built 4D image analysis to study the cell‐surface topography of B cells of the Ramos Burkitt's Lymphoma line and the spatiotemporal organization of the IgM‐BCR. Ramos B‐cell surfaces were found to form dynamic networks of elevated ridges bridging individual microvilli. A fraction of membrane‐localized IgM‐BCR was found in clusters, which were mainly associated with the ridges and the microvilli. The dynamic ridge‐network organization and the IgM‐BCR cluster mobility were linked, and both were controlled by Arp2/3 complex activity. Our results suggest that dynamic topographical features of the cell surface govern the localization and transport of IgM‐BCR clusters to facilitate antigen screening by B cells.
Targeting gut dysbiosis against inflammation and impaired autophagy in Duchenne muscular dystrophy
Authors: Kalkan Hilal , Pagano Ester , Paris Debora , Panza Elisabetta , Cuozzo Mariarosaria , Moriello Claudia , Piscitelli Fabiana , Abolghasemi Armita , Gazzerro Elisabetta , Silvestri Cristoforo , Capasso Raffaele , Motta Andrea , Russo Roberto , Di Marzo Vincenzo , Iannotti Fabio Arturo 
Published: January 2023

AbstractNothing is known about the potential implication of gut microbiota in skeletal muscle disorders. Here, we provide evidence that fecal microbiota composition along with circulating levels of short‐chain fatty acids (SCFAs) and related metabolites are altered in the mdx mouse model of Duchenne muscular dystrophy (DMD) compared with healthy controls. Supplementation with sodium butyrate (NaB) in mdx mice rescued muscle strength and autophagy, and prevented inflammation associated with excessive endocannabinoid signaling at CB1 receptors to the same extent as deflazacort (DFZ), the standard palliative care for DMD. In LPS‐stimulated C2C12 myoblasts, NaB reduces inflammation, promotes autophagy, and prevents dysregulation of microRNAs targeting the endocannabinoid CB1 receptor gene, in a manner depending on the activation of GPR109A and PPARγ receptors. In sum, we propose a novel disease‐modifying approach in DMD that may have benefits also in other muscular dystrophies.
The Properties of Particleboard Composites Made from Pleurotus ostreatus Baglog Waste Using Citric Acid and Sucrose Adhesive
Authors: Ningrum Riska Surya , Khairaummah Alfiani , Puspitasari Inneke , Bazhafah Ananda Suci , Ratnaningtyas Nuniek Ina , Mumpuni Aris , Ismadi Ismadi , Kusumah Sukma Surya 
Published: January 2023

Pleurotus ostreatus (PO) is one of the edible mushrooms cultivated in baglog as the medium. Baglog’s productive age is around 4-5 weeks. The more PO produced, the amount of baglog waste also increases. The main component of baglog is wood sawdust, which contains lignocellulose; therefore, baglog has great potential to be used as a raw material for making particleboard. This research aims to make particleboard from baglog waste and determine the effect of the type and adhesive concentration on the physical and mechanical properties of the particleboard that is produced. Particleboard is made by mixing baglog waste, whose particle size is 40 mesh, with citric acid and sucrose adhesives whose concentrations are varied between 50%, 60%, and 70%. Furthermore, the particleboard was formed using a hot press machine (200 °C, 10 MPa) for 15 minutes. The obtained particleboard will be analyzed for its physical properties, including density, moisture content, water absorption, thickness swelling, morphology, and mechanical properties, including modulus of rupture (MOR) and modulus of elasticity (MOE). The test refers to the JIS A 5908-2003 type 8 standard. As a result, particleboard made using citric acid adhesive (citric acid 70%; C70) has a better physical and mechanical properties compared to sucrose adhesive, with a density value of 0.86 g/cm³, moisture content of 4.118%, thickness expansion of 3.992%, water absorption capacity of 36.89%, 13.456%, MOR 9.682 MPa, and MOE 1.455 GPa.
Social Needs Screening in Hospitalized Pediatric Patients: A Randomized Controlled Trial
Authors: Lopez Michelle A. , Yu Xian , Hetrick Rebecca , Raman Shivani , Lee Jessica , Hall Julie , Tran Katherine , Vonasek Bryan , Garg Arvin , Raphael Jean , Bocchini Claire 
Published: January 2023

BACKGROUND AND OBJECTIVE
Addressing adverse social determinants of health is an upstream approach to potentially improve child health outcomes and health equity. We aimed to determine if systematically screening and referring for social needs in hospitalized pediatric patients increased families’ enrollment in publicly available resources.

METHODS
Randomized controlled trial at a large urban children’s hospital enrolled English-speaking caregivers of patients 0 to 36 months of age on the general pediatrics service from June 2016 to July 2017. The intervention arm received the WE CARE Houston social needs intervention (screener and resource referrals based on screening results and receptiveness to help); the control arm received standard of care. Baseline social risk data were collected for all participants. Caregivers who screened positive for mental health need, substance abuse, or domestic violence received additional support, including from social workers. The primary outcome was enrollment in resources at 6 months postdischarge. Univariate and multivariable analysis was performed to identify associations.

RESULTS
Our study sample consisted of 413 caregivers from diverse sociodemographic/socioeconomic backgrounds. Overall, 85% of study participants had ≥1 social risk (median 2, range 0–9). WE CARE Houston identified caregiver employment, health insurance, primary care physician, depression, childcare, smoking, and food resources as the most prevalent social needs. Among these, caregivers were most receptive to resources for childcare, mental health, health insurance, and primary care. There was no significant difference in enrollment in new resources by study arm.

CONCLUSION
Screening for social needs in the hospital is feasible and can result in the identification of social needs, but further work is needed to successfully address these needs.
PERBANDINGAN CANTRANG DENGAN JARING TARIK BERKANTONG DI TEGAL
Authors: Suharyanto Suharyanto , Goenaryo Goenaryo , Dewi Priyantini , Hidayat Taufik , Efyanto Tonny Kusumo 
Published: January 2023

Peraturan Menteri Kelautan Perikanan Nomor 18 tahun 2021 mengatur tentang jaring tarik berkantong sebagai tindaklanjut larangan terhadap cantrang. Salah satu hal yang membedakan kedua alat penangkap ikan ini adalah pada cantrang bagian atas kantong menggunakan square mesh window dan pada jaring tarik berkantong menggunakan square mesh pada seluruh bagian kantong. Penelitian ini bertujuan untuk komparasi rasio dimensi jaring tarik berkantong yang merupakan modifikasi cantrang serta membandingkan dengan rasio pada Standar Nasional Indonesia (SNI) 01-7236-2006 untuk cantrang. Pengumpulan data dilakukan pada Maret hingga Mei 2022 di Pelabuhan Perikanan Pantai Tegal dengan metode obervasi dan analisis data terhadap perbandingan rasio yang mengacu SNI tersebut. Hasil studi menunjukan bahwa nilai yang diperoleh rasio jaring tarik berkantong sampel dengan tetapan SNI adalah sebagai berikut rasio f/b adalah 0,063, rasio g2/h adalah 0,731, rasio c/b adalah 0,51 dan rasio e/b adalah 0,441. Hal ini mengindikasikan ukuran jaring tarik berkantong semakin memanjang namun menyempit, jaring tersebut telah memenuhi regulasi dengan bentuk mata jaring square mesh dengan ukuran mesh size minimal 2 inci. Namun di lapangan harus dilakukan sosialisasi serta pengawasan terhadap regulasi diatas.
IDENTIFIKASI PERMASALAHAN DAN STRATEGI PENGOLAHAN IKAN LELE PADA UKM PENGOLAH IKAN DI KABUPATEN BOGOR
Authors: Supenti Lilis , Suhrawardan Hendria , Yuniarti Tatty , Arimukti Kurnia Desy , Setiarto R. Haryo Bimo 
Published: January 2023

Pengolahan ikan lele pada UKM di Kabupaten Bogor perlu dilakukan identifikasi dari sistem input, proses, hingga produksi agar diketahui permasalahan yang ada sehingga dapat memberikan rekomendasi dan strategi yang efektif pada usahanya. Penelitian ini bertujuan mengidentifikasi permasalahan pengolahan ikan lele pada UKM pengolah ikan di kabupaten Bogor dan memberikan rekomendasi strategi guna perbaikan kualitas produk dan pengembangan usaha pada UKM pengolah ikan di Kabupaten Bogor. Metode penelitian yang dilakukan adalah observasi partisipatif dengan analisis deskriptif diagram tulang ikan. Penelitian dilakukan di empat lokasi unit pengolahan ikan lele, yaitu UKM Cihil Mandiri Sejahtera, UKM Darma Tirta, UKM Amanah Frozen dan UKM Anugrah Gile. Hasil penelitian menunjukkan bahwa dari empat lokasi tersebut, ditemukan permasalahan utama yang serupa yaitu permasalahan bahan baku dan permasalahan pada proses penyiangan. Sementara untuk UKM Amanah Frozen terdapat satu lagi permasalahan utama, yaitu kurangnya pengelolaan terhadap limbah dari hasil proses produksi. Permasalahan pada bahan baku, meliputi kurang terjaminnya keamanan pangan pada bahan baku, kurangnya higienitas dan pemilihan bahan baku yang belum berstandar. Permasalahan pada proses penyiangan, yaitu kurang tepatnya langkah yang dilakukan pada saat pemingsanan/ pematian ikan, menyebabkan lamanya proses penyiangan dan terjadinya kemunduran mutu. Adapun permasalahan tentang tidak adanya pengelolaan limbah yang dihasilkan dari kegiatan produksi, sebaiknya limbah tersebut perlu diolah dan dimanfaatkan kembali agar menjadi produk yang memiliki nilai tambah. Kesimpulan dari penelitian ini adalah permasalahan pada empat UKM yang diteliti memiliki kecenderungan yang sama yaitu disebabkan oleh kurangnya pemahaman dan kepedulian pekerja dalam menangani bahan baku olahan, masih sederhananya peralatan yang digunakan, dan ruang produksi yang kurang memadai. Studi lanjutan diperlukan untuk mengetahui mutu produk yang dihasilkan oleh empat UKM tersebut sehingga dapat memperdalam kajian.