bluuebunny/crossref_metadata_2025_split huggingface dataset:
PRECLINICAL MOUSE MODELS IN ADOPTIVE CELL THERAPIES OF CANCER
Authors: Rajčević Uroš , Smole Anže 
Published: December 2022

Engineered T cell-based therapies are an advanced approach for cancer immunotherapy using genetically modified T cells. To date, CD19 and BCMA targeting Chimeric Antigen Receptor (CAR) T cells have been approved for the treatment of certain hematologic malignancies. The success of CAR-T cells is offset by limited efficacy, particularly in solid tumors, and safety risks. Preclinical in vivo research, which is highly dependent on reliable mouse models, has been a cornerstone of the success story of adoptive cell therapies and continues to provide invaluable information for the development of the next generation of cellular immunotherapies. In this review we describe four of the most common preclinical mouse models: Xenograft models, syngeneic models, immunocompetent transgenic models and humanized mouse models. All of these have advantages and disadvantages and no mouse model can fully recapitulate the human situation because of inherent differences and treatment complexity. Reports suggest that using a combination of mouse models in preclinical in vivo research prior to translating the treatment to humans in clinical trials can help incrementally improve the quality, safety, and efficacy of the treatment and provide more comprehensive information than a single model.

PREDKLINIČNI MIŠJI MODELI PRI ADOPTIVNIH CELIČNIH TERAPIJAH RAKA
Povzetek: Napredne terapije na osnovi biotehnološko spremenjenih limfocitov T predstavljajo moderen pristop k imunoterapiji raka z uporabo genetsko spremenjenih limfocitov T. Do danes sta bili za zdravljenje hematoloških malignosti odobreni terapiji s himernimi antigenskimi receptorji usmerjenimi proti antigenoma CD19 in BCMA. Uspeh zdravljenja s celicami CAR-T pa ovirajo omejena učinkovitost, še posebej pri solidnih tumorjih in varnostna tveganja. Predklinične raziskave in vivo, ki so močno odvisne od zanesljivih mišjih modelov, so bile kritični dejavnik zgodbe o uspehu adoptivnih celičnih terapij in še vedno zagotavljajo neprecenljive podatke za razvoj naslednje generacije celičnih imunoterapij. V preglednem članku povzemamo štiri najpogostejše predklinične mišje modele: ksenografte, singenetske modele, imunokompetentne transgenske modele in humanizirane mišje modele. Vsi opisani modeli imajo svoje prednosti in slabosti in noben mišji model ne more do popolnosti preslikati situacije v človeškem pacientu zaradi med-vrstnih razlik ter izjemne zapletenosti zdravljenja. Podatki iz literature kažejo na to, da lahko uporaba kombinacije mišjih modelov v predkliničnih in vivo raziskavah pred translacijo zdravljenja na ljudi v kliničnih poskusih pripomore k postopnemu izboljšanju kakovosti, varnosti in učinkovitosti zdravljenja in zagotovi bolj celostni nabor podatkov kot en sam model.
Ključne besede: mišji model; ksenograft; singenetski; transgenski; humanizirani; CAR-T; adoptivna celična terapija
THE ROLE OF COMMODITY DUMPING IN ENCOURAGING THE IRAQI CONSUMER TO BUY NON- ESSENTIAL GOODS
Authors:   1مدرس دكتوره، مركز بحوث السوق وحماية المستهلك، جامعة بغداد، بغداد، العراق. wesalab@mracpc.uobaghdad.edu.iq, حسين وصال عبدالله , الخفاجي محمود عبدالله جاسم ,   2استاذ مساعد دكتور، مركز بحوث السوق وحماية المستهلك، جامعة بغداد، بغداد، العراق. mahmud@mracpc.uobaghdad.edu.iq
Published: December 2022

The research aims to study the effect of the commodity dumping phenomenon that Iraq suffered after 2003 on the consumption pattern of individuals, towards the acquisition of non-essential goods (luxury). To achieve our goal we relied on the questionnaire as a main tool for obtaining information related to the research, and it was distributed on a random sample of consumers in the city of Baghdad with 250 questionnaires. The answers of the research sample were analyzed using the statistical program (SPSS). The percentage weights and the factorial analysis method were used also to arrange the variables that affected on changing consumption patterns. The research reached a set of conclusions:	The degree of impact of the variables (economic, social and geographical) reached to76.503%, which considers as a good percentage of their impact on the consumer. The economic effects ranked first in their impact by changing the consumption pattern and the trend towards buying unnecessary goods, followed by the geographical effects and social effects respectively. One of the most important recommendations of the research was the quantitative and qualitative determination of the goods allowed to enter the local markets in accordance to quality standards, imposing high customs tariffs on imported goods, especially those non-essential goods, and control of border ports.
Simulation of Hybrid Mesh Turbomachinery using CFD and Additive Technologies
Authors: Sazonov Yuri A. , Mokhov Mikhail A. , Gryaznova Inna V. , Voronova Victoria V. , Tumanyan Khoren A. , Frankov Mikhail A. , Balaka Nikolay N. 
Published: December 2022

This paper develops schematics and evaluates the performance of hybrid mesh turbomachinery at the patenting stage of individual technical solutions. This type of turbomachine uses reduced-sized blades and also forms flow channels with a mesh structure between the blades. The research methods are based on simulations using computational fluid dynamics (CFD) and additive technologies. An intermediate conclusion is that a new scientific direction for investigating and creating hybrid mesh turbomachinery equipped with mesh jet control systems was formed to develop Euler's ideas. This paper describes new possibilities for the simultaneous implementation of two workflows in a single impeller: 1) Turbine workflow, and 2) Compressor workflow. Calculation methods showed possible improvements in the performance of the new turbomachines. This paper considers options for mesh turbomachine operation in the two-stage gas generator mode with partial involvement of atmospheric air in the workflow. Preliminary calculations based on examples show that it is possible to expect a two- to four-times increase in thrust when using hybrid mesh turbomachines. Ongoing studies mainly focus on developing multi-mode turbomachinery that works in complicated conditions, such as offshore oil and gas fields, but some research results are applicable in other industries, for example, in developing hybrid propulsion systems or propulsors. Doi: 10.28991/CEJ-2022-08-12-011 Full Text: PDF
The Effect of Nordic Walking Exercise Training on Physical Fitness, Physical Activity Level, Anxiety-Depression and Quality of Life in Smokers: A Randomized Controlled Trial
Authors: ACAR Manolya , YARIMKAYA Nur Sena , TEKİNDAL Mustafa Agah 
Published: December 2022

Aim: The aim of study was to investigate effects of nordic walking exercise (NWE) on physical fitness,
physical activity, anxiety-depression level and quality of life in smokers.
Material and Methods: 30 smoking individuals with a mean age of 31.45±12.75 years were assigned
randomly into two groups: NWE (n=15) or control group (n=15). NWE group performed NWE three times
a week for 6 weeks and gradually increasing to 45 min a day. No intervention was made in control group.
The health-related physical fitness level was assessed with arm curl test (upper extremity endurance),
chair sit and stand test (lower extremity endurance), two minutes step test (aerobic endurance), sit and
reach and back scratch test (flexibility), eight foot up and go test (balance), 6-minute walk test (MWT)
(cardiopulmonary endurance). Physical activity levels with International Physical Activity Questionnaire
(IPAQ) short form, anxiety-depression level with Beck Depression Questionnaire, quality of life with
Nottingham Health Profile (NHP) were evaluated. The differences in measurement parameters between
two groups were evaluated by the Mann Whitney U Test since the data distribution was nonparametric.
The distinction between categorical variables were determined by Chi-square test.
Results: 6-MWT distance (p=0.005), two minutes step (p=0.022), IPAQ walking scores (p=0.028)
statistically significant improvements were observed in NWE group. In control group, 6 MWT distance
(p=0.025), two minutes step (p=0.032), sit and reach (p=0.043) scores decreased statistically
significantly. 6 MWT distance (p=0.006), two minutes step (p=0.021), 8 foot up and go (p=0.005),
IPAQ walking (p=0.045), moderate intensity activity (p=0.038), total scores (p=0.013), NHP emotional
(p=0.045), total (p=0.045) scores significantly differed in favor of NWE group.
Conclusion: It is thought that NWE may be effective and alternative exercise approache in increasing
physical fitness, physical activity level and quality of life in smokers and guided to rehabilitation
programme.
Investigation on Demographic Characteristics of Pregnant Patients with Thyroid Dysfunction- Ege University Sample
Authors: ERDOĞAN Mehmet , BAYRAMOVA Günel , ÖZIŞIK Hatice , SUNER Aslı 
Published: December 2022

Aim: Thyroid diseases can cause maternal and fetal adversities, and proper diagnosis, follow-up and
treatment during pregnancy requires special attention. In the evaluation of thyroid functions during
pregnancy, free thyroxine (FT4) is used primarily with thyroid-stimulating hormone (TSH). Our aim is to
investigate the prevalence and the effects of thyroid dysfunction during pregnancy.
Material and Methods: Our study is a prospective study including 960 pregnant women and spanning
from November 2017 to May 2019 in Ege University Endocrinology outpatient clinic.100 pregnant
women with thyroid dysfunction out of 960 pregnant women were included in the study. Maternal
age, gestational trimester, family history of the thyroid disorder, TSH, FT4, free triiodothyronine (FT3),
anti-thyroid peroxidase antibody (Anti-TPO), anti-thyroglobulin antibody (Anti-TG), thyrotropin (TSH)
receptor antibody (TRAb) were collected. The correlations between TSH, FT3 and FT4 were examined.
Results: In the study, the mean age of pregnant patients was 29.33 ± 5.97. Anti-TPO was positive %18 and
Anti-TG was positive (5%). 24 of 100 (24%) patients had nodules. 1 (8.3%) patient with hyperthyroidism
was positive for TRAb. Age differences in patients with or without nodule were not statistically significant.
1 (1%) of the patient had Graves disease, 81 (81%) had subclinical hypothyroidism, 7 (7%) had clinical
hypothyroidism, 11 (11%) had gestational thyrotoxicosis. The frequency of prematurity was determined
in 7 patients (15.6%) by the data of 45 pregnant women who gave birth.
Conclusion: TSH levels in pregnant patients with positivity for anti-TPO and anti-TG were significantly
higher than pregnant patients with negativity for anti-TPO and anti-TG. In addition, the relationship
between thyroid diseases and nodule frequency, autoimmunity, premature birth in pregnant women
were not detected. More comprehensive study series are needed.
Elämäni on muuttunut kokonaan
Authors: Aarva Pauliina , Väänänen Tiina , Kankkunen Tiia-Tuulia 
Published: December 2022

Luontaishoidot, joita kutsutaan myös täydentäviksi ja vaihtoehtoisiksi hoidoiksi tai perinnehoidoiksi, jakavat voimakkaasti mielipiteitä yhteiskunnassamme. 2000-luvulla hoidoille on vaadittu kahdenlaista sääntelyä, yhtäältä rajoittavaa lakia ja toisaalta lainsäädäntöä niiden käytön helpottamiseksi. Julkinen keskustelu on painottanut tutkimusnäytön puutetta ja vaihtoehtohoitojen potentiaalisia vaaroja. .

Tutkimuksessa selvitettiin sisällönanalyysin keinoin, mitä luontaishoitojen käyttäjien perustelut hoitojen käytölleen ja niistä saadulle avulle kertovat luontaishoitokulttuurista, joka on osa laajempaa terveyskulttuurin kenttä. Tutkimusaineisto käsitti 5366 kirjallista vastausta kysymykseen luontaishoitojen tuomasta avusta vastaajille. Kysymys esitettiin oikeusministeriön ylläpitämässä Otakantaa.fi-verkkopalvelun luontaishoitokyselyssä 8.10.–15.12.2021.

Tulokset vahvistavat aikaisempia tutkimustuloksia luontaishoitojen koetuista hyödyistä vaivojen hoidossa ja tuesta elämäntapamuutoksille. Perustelut luontaishoitojen käytölle ja niistä avun saannille tiivistyvät kolmeen perustelutyyppiin, jotka ovat vetoaminen käytännössä havaittuihin, arjessa koettuihin hyötyihin, tyytymättömyyteen terveydenhuollosta saatuun apuun ja viittaaminen kokonaisvaltaiseen hoitotapaan.

Käyttäjien perustelut kertovat terveyskulttuurimme monimuotoisuudesta. Aineiston mukaan käyttäjien näkemykset luontaishoidoista ovat myönteisempiä kuin julkisessa keskustelussa pinnalla olleet kannanotot hoitojen mahdollisesta haitallisuudesta. Vaikka kiistellyt hoidot sijoittuvat virallisen terveydenhuollon marginaaliin, niillä on luontaishoitokulttuurissa selkeä ja arvostettu paikka lääketieteellisten hoitojen rinnalla. Tutkimustulokset tuovat esiin luontaishoitojen käyttäjien näkökulmia hoitoja koskeviin yhteiskunnallisiin kiistoihin ja lisäävät terveyskulttuurisen erilaisuuden ymmärtämistä.
Mielikuvien, ruumiillisuuden ja perinteen kohtaamispisteessä
Authors: Silvonen Viliina , Kuittinen Emmi 
Published: December 2022

Mielikuvien, ruumiillisuuden ja perinteen kohtaamispisteessä. Tapaustutkimus tunteista nykyajan muusikko-itkijän itkuvirsiperformansseissa.

Nyky-Suomessa tunnettu itkuperinne on muotoutunut karjalaisten ja inkeriläisten (inkerikkojen) perinteiden pohjalta. Alkujaan suullisena välittynyt rituaalinen perinne elää nykyajassa myös kirjallisena ja useimmin muissa kuin rituaalitilanteissa.

Artikkelissa paneudumme nykyajan itkuvirsien tunteisiin. Lähestymme tunteita affektiivisina käytäntöinä: tunne nähdään sosiokulttuurisesti rakentuvana ruumiillisena kokemuksena ja merkityksenannon prosesseina. Tapaustutkimuksemme syventyy yhden kansanmuusikkona ja taiteilijana toimivan itkijän, Emmi Kuittisen, näkemyksiin ja kokemuksiin itkuperinteestä ja itkujen tunteista, mutta tarkastelemme näitä myös suhteessa koko itkuperinteeseen. Pääkysymyksemme on: Mistä ja miten nykyitkuvirsien tunteet muodostuvat? Artikkelimme osoittaa, että tunne syntyy itkun aiheen, mielikuvien, esityksen ja ruumiillisuuden kohdatessa. Itkijän käsitys itkuvirsien tunteista kumpuaa varhaisista itkuvirsitutkimuksista ja kirjallisista kuvauksista, arkistoihin tallennetuista itkuvirsiaineistoista sekä itkijän omista kokemuksista niin arkisessa elämässä kuin itkuvirsien esittäjänä. Performanssin vuorovaikutteinen, kokonaisvaltainen luonne ja esitystilanne vaikuttavat tunteeseen. Ruumiillisuus on keskeinen tekijä tunteiden luomisessa itkuperformanssiin. Perinteen jatkumon näkökulmasta tunne hahmottuu eri aikojen ja erilaisten sosiokulttuuristen kontekstien välille yhteyksiä luovana linkkinä.

Metodologisesti artikkeli asettuu tutkijan ja tutkittavan yhteistyötä korostaviin suuntauksiin. Artikkeli rakentuu itkijän ja tutkijan rinnakkain kulkevista teksteistä. Itkijä kirjoittaa kustakin tutkimuksemme näkökulmasta omakohtaisesti, ja tutkija analysoi tätä kerrontaa teoreettista ja tutkimushistoriallista taustaa vasten. Kirjoitustyön taustana on etnografiset haastattelut ja havainnointi. Täydentävänä aineistona on mediamateriaalia sekä itkuvirsiäänitteitä ja -esityksiä. Artikkelissa tuotamme tietoa muusikko-itkijän tunteista, niiden kulttuurisesta kontekstista ja merkityksistä. Artikkeli lisää tietoa myös nyky-Suomessa ilmenevän itkuperinteen moninaisuudesta.
Pharmacological and clinical approach to plant based complementary health products in lower urinary system diseases in cats and dogs
Authors: GÜNEŞ Yiğit , ANLAŞ Ceren , DOKUZEYLÜL Banu 
Published: December 2022

Medicinal plants, which are widely used in the treatment of many diseases in folk medicine, are alternative treatment approaches that allow to overcome the limitations of modern treatments such as high treatment costs and difficulty in accessing health services. In addition to their traditional uses, the World Health Organization (WHO) also recommends the use of medicinal plants as alternative applications, especially in countries where have limited access to modern medical facilities. Limitations on the methods used in the treatment of lower urinary tract diseases such as urinary tract infection and urolithiasis in both human and veterinary practice (high treatment cost, low tolerability, development of antibacterial resistance, etc.) have brought the use of natural products of herbal origin within the scope of supportive/complementary treatment approaches. Although the mechanism of action of medicinal plants in the treatment of lower urinary tract diseases is not clearly known, studies have shown that they increase the glomerular filtration rate; and they can be complementary alternatives to conventional treatment due to their anti-lithogenic, antibacterial, antioxidant and anti-inflammatory activities. Patients that referred to with one or more of the symptoms of urinary system diseases such as polyuria, pollakiuria, dysuria, stranguria, anuria, hematuria, urinary incontinence constitute the case group of one of the first three systemic diseases most frequently brought to the clinic. Failure to intervene in the diseases shaped in the lower urinary system in a timely manner causes negative consequences such as the disease becoming chronic, the progression of the disease to the upper urinary system in progressive cases, and a decrease in the quality of life. Complementary products used in addition to medical treatment are sometimes used for prophylactic purposes. In this context, many supplements have been prescribed for different diseases in small animal practice in recent years. In this review, it is aimed to convey current developments about medicinal plants, which are used effectively within the scope of supportive treatment practices in lower urinary system diseases of cats and dogs, to veterinary clinical practice.
The New Zealand Experience: Thank you Jean Monnet
Authors: Holland Martin 
Published: December 2022

The trajectory of EU Studies in New Zealand has taken multiple paths over the last quarter century, seen a proliferation of organisations and acronyms but a constant and secure funding base maintained by successive tranches of Jean Monnet and other EU funding mechanisms. The longevity of such a benign environment is now, however, uncertain. It is counter-intuitive, perhaps paradoxical, to witness a change in EU support for academic experts at a time when EU public diplomacy has never been more important.
Gaya Manajemen Konflik Perawat Manajer di Rumah Sakit: Implikasi Manajemen Keperawatan di Masa Pandemi Covid-19
Authors: Suganda Tomy , Huda Kholis Khoirul , Suwahyu Romy , Septiani Nurul 
Published: December 2022

Latar Belakang: Pandemi COVID-19 telah menyebabkan sebagian besar dunia mulai berpikir secara berbeda. Tantangan dan permasalahan akibat pandemi COVID-19, bila tidak dikelola dengan baik akan berdampak pada keselamatan pasien, keselamatan staf dan berpotensi dapat menyebabkan konflik-konflik terjadi. Artikel ini, menggambarkan gaya manajemen konflik perawat manajer di rumah sakit sebagai implikasi manajemen keperawatan di masa pandemi COVID-19. Metode: Penelitian ini menggunakan tinjauan pustaka PRISMA, melalui database perpustakaan digital yang terhubung dengan berbagai laman publikasi ilmiah melalui kata kunci seperti "manajemen konflik" "gaya manajemen konflik","COVID-19",serta“konflik perawat”. Kriteria kelayakan menggunakan berbagai jenis metode penelitian termasuk metode kuantitatif, kualitatif dan review yang menggambarkan gaya manajemen konflik manajer keperawatan dalam penyelesaian konflik. Hasil: gaya manajemen konflik yang paling dominan digunakan adalah gaya manajemen konflik kompromi, menghindar dan integrasi dengan masing-masing yaitu 23,8%, diikuti oleh kolaborasi 20,6% serta akomodasi dan kompetisi masing-masing 0,04%. Kesimpulan: Implikasi yang dapat dilakukan dalam menghadapi tantangan dan permasalahan akibat pandemi COVID-19 adalah analisa situasi konflik melalui faktor yang mempengaruhi, komunikasi, kolaborasi, dan kordinasi dengan pihak-pihak yang berkaitan sebelum menentukan gaya manajemen konflik yang akan digunakan.
Strengthening Javanese Art at the Sanggar Baladewa Binjai, North Sumatra
Authors: Agustono Budi , Mhd. Pujiono  , Dewi Heristina 
Published: December 2022

The Javanese populace is dispersed throughout Indonesia, including North Sumatra. The development of Javanese culture and art in North Sumatra paralleled the increasing number of Javanese in that region. In North Sumatra, cultural and artistic studios (sanggar) have become one of the driving forces behind the development of Javanese culture and the arts. One of them is Sanggar Baladewa in Binjai City, where Javanese arts and culture are developed and displayed. However, the sanggar faces managerial and financial difficulties. Therefore, during this community service project, efforts have been made to strengthen the Sanggar Baladewa in North Sumatra and to promote Javanese culture. This activity consists of providing sanggar members with assistance in the form of a Focus Group Discussion (FGD) over the course of three months. In addition to providing assistance, the community service team has provided sanggar members with musical instruments and accessories for use in traditional music performance activities. The lecture method, question-and-answer sessions, and demonstrations are utilized in its implementation. This Community Service has produced results in the form of services to increase public awareness of Javanese culture in North Sumatra by providing sanggar members with training to increase their creativity, innovation, and skill in the field of cultural arts.
Cultural Policy: Some initiatives and trends to manage cultural diversity in Indonesia
Authors: Purwanto Semiarto Aji 
Published: December 2022

This article discusses the cultural policy in the state level. The discussion on cultural policy cannot be separated from the idea of ​​the state's interest in maintaining citizens' trust in government programs. The strong role of the state in formulating cultural policies is often seen as the hegemony of the state over society, in the perspective of governmentality, as if the state has the power to determine what its citizens may do.
In Indonesia, cultural policies have also been tried to be implemented from time to time. However, some of our cultural policies tend to look at the macro and general aspects. Local initiatives are indeed seen, but in the end, macro ideas are taken into consideration. Besides being aimed at tourism, the development of local culture is also carried out by referring to certain standards that come from outside the community context. One of the standards that is currently popular is to identify a tradition and then trying to convince the public that the tradition has the right to be included in the category of national intangible cultural heritage.
I try to reformulate cultural policies, in the context of Indonesia, which has diverse traditions, amid this global change, as an effort to maintain the dynamic of local traditions. It can be pursued primarily by protecting traditional (adat) communities and their cultural works. It is not a question of 'extinction' or 'sustainability' but how these traditions can develop in the community, become part of the community, and rediscover its relevance to conditions outside the rapidly growing community.