bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ileoileal knotting a rare cause of double loop small bowel obstruction, diagnostic and intraoperative challenge at Ethiopian Leku district hospital,sidama region, April 2023 ,case report
Authors: Specialist) Asfaw Kibret(Senior integrated Emergency surgery profesional 
Published: April 2023

Abstract
Background: Intestinal obstruction is common cause for abdominal surgeries. Among the causes for intestinal obstruction ileal knotting is the unusual and rare cause with very few case reports in the globe and in Ethiopia. Almost all cases were intraoperative surprises. We report a case of strangulated closed small bowel loop obstruction caused by ileoileal knotting at distal ileum near to ileocecal junction, its diagnostic and management challenges and the role of the “Integrated Emergency surgical officers(IESO)’’ for early emergency surgical interventions in district primary hospitals in Ethiopia where there is scarce general specialist surgeon.
Case presentation: Here we discuss a 78yrs old male Ethiopian patient presented to our district hospital with sign symptoms of strangulated small bowel obstruction and exploratory laparatomy was done with intraoperative surprise of ileoileal knot with gangrenous closed loop obstruction at ileocecal junction. The gangrenous segment was resected and ileo-ascending colon anastomosis was done.The post operative stay was uneventful and patient discharged on his 7th post operation date.
Conclusion: Here we present this case to highlight difficulty of preoperative diagnosis and the need of high index of suspicion as well as the management challenges of resection anastomosis when the knot is near to ileocecal junction and the undeniable role of emergency surgical officers for early interventions of such emergency cases who need early interventions.
Yeast diversity in pit mud and related volatile compounds in fermented Zaopei of Chinese Strong-flavour Baijiu
Authors: Yan Shoubao , Yang Jie , Shen TingTing , Guang Jiaquan , Cuie Shi 
Published: April 2023

Abstract
Chinese strong-flavour liquor is produced via a traditional solid-state fermentation strategy facilitated by live microorganisms in pit mud-based cellars. For the present analysis, pit mud samples from different spatial locations within fermentation cellars were collected, and the yeast communities therein were assessed via culture-based and denaturing gradient gel electrophoresis (DGGE) approaches. These analyses revealed significant differences in the composition of yeast communities present in different layers of pit mud. In total, 29 different yeast species were detected, and principal component analyses revealed clear differences in microbial diversity in pit mud samples taken from different cellar locations. Culture-dependent strategies similarly detected 20 different yeast species in these samples. However, while Geotrichum silvicola, Torulaspora delbrueckii, Hanseniaspora uvarum, Saturnispora silvae, Issatchenkia orientalis, Candida mucifera, Kazachstania barnettii, Cyberlindnera jadinii, Hanseniaspora spp., Alternaria tenuissima, Cryptococcus laurentii, Metschnikowia spp., and Rhodotorula dairenensis were detected via a PCR-DGGE approach, they were not detectable in culture-dependent analyses. In contrast, culture-based approaches led to the identification of Schizosaccharomyces pombe and Debaryomyces hansenii in these pit mud samples, whereas they were not detected using DGGE fingerprints profiles. An additional HS-SPME-GC-MS-based analysis of the volatile compounds present in fermented Zaopei samples led to the identification of 66 such compounds, with the highest levels of volatile acids, esters, and alcohols being detected in fermented Zaopei from lower layer samples. A canonical correspondence analysis (CCA) suggested they were significant correlations between pit mud yeast communities and associated volatile compounds in fermented Zaopei.
Evaluation of ‘implications for research’ sections in systematic reviews of interventions in advanced cancer patients – a meta-research study
Authors: Siemens W. , Bantle G. , Ebner C. , Blümle A. , Becker G. , Schwarzer G. , Meerpohl J. J. 
Published: April 2023

Abstract
Background
Implications for research (IfR) sections are an important part of systematic reviews (SRs) in healthcare. The PRISMA 2020 statement recommends discussion of the implications of the results for practice, while Cochrane Reviews require an IfR section. However, it is unclear to what extent systematic reviews discuss IfR and if this section is useful.
We aimed i) to assess whether systematic reviews include an IfR section and ii) to evaluate which elements informed reporting of IfR.
Methods
We conducted a meta-research study based on SRs of interventions in advanced cancer patients from a previous project (CRD42019134904).
We assessed if the following predefined IfR variables were referred to in the included SRs: patients, intervention, control, outcome, study design (PICOS); Grading of Recommendations, Assessment, Development and Evaluation (GRADE) domains: risk of bias, inconsistency, indirectness, imprecision, publication bias. Data were independently extracted by three reviewers after piloting the data extraction form. Discrepancies were resolved in weekly in-depth discussions.
Results
We included 261 SRs. The majority evaluated a pharmacological intervention (244, 93.5%); twenty-nine were Cochrane Reviews (11.1%).
Four out of five SRs included an IfR section (210, 80.5%). PICOS elements commonly addressed in IfR sections were ‘intervention’ (121, 57.6%), ‘patient‘ (113, 53.8%) and ‘study design’ (107, 51.0%). The most frequent PICOS combinations were ‘patient and intervention‘ (71, 33.8%) and ‘patient, intervention and study design‘ (34, 16.2%).
GRADE domains were rarely used for informing IfR recommendations: ‘risk of bias‘ (2, 1.0%), and ‘imprecision‘ (1, 0.5%), ‘inconsistency‘ (1, 0.5%).
Additional factors informing IfR recommendations were considerations on cost effectiveness (9, 4.3%), reporting standards (4, 1.9%), and individual patient data meta-analysis (4, 1.9%).
Conclusion
Although four out of five systematic reviews of our sample included an IfR section, these were mostly considering only selected PICOS elements and GRADE domains were used rarely to guide future research recommendations.
In the absence of established reporting standards, we propose more comprehensive and structured IfR sections in SRs informed by PICOS elements and GRADE domains. We suggest further empirical and theoretical work to eventually develop guidance on what IfR elements to consider and how to report IfR in SRs of interventions.
The impact of the COVID-19 pandemic on respiratory viruses in hospitalized children with lower respiratory tract infections in Suzhou, southeast of China
Authors: Chen Sainan , Xu Xueyun , Zhou Luting , Yuan Qi , Wu Min , Shao Xuejun , Wang Yuqing 
Published: April 2023

Abstract
Background The coronavirus disease 2019 (COVID-19) pandemic has led to the use of multifaceted non-pharmaceutical interventions (NPIs) to mitigate disease spread. NPIs also have an impact on the prevalence of non-SARS-CoV-2 viruses. We aimed to explore the prevalence of common respiratory viruses among hospitalized children with lower respiratory tract infections (LRTIs) in Suzhou, southeast China, during the COVID-19 pandemic.
Methods Medical records and nasopharyngeal specimens of children hospitalized with LRTIs in the Children's Hospital of Soochow University from 2018 to 2021 were collected. Seven common respiratory viruses, namely, respiratory syncytial virus (RSV), adenovirus (ADV), influenza virus types A and B (IV-A and IV-B), parainfluenza virus types 1, 2, and 3 (PIV l to 3), were detected by direct immunofluorescence. Fluorescent quantitative PCR was performed to detect Bocavirus (HBoV), and reverse transcription-polymerase chain reaction (RT‒PCR) was performed to detect human respiratory rhinovirus (HRV) and human metapneumovirus (HMPV).
Results A total of 13873 children including 8429 (60.8%) patients in 2018-2019 and 5444(39.2%) patients in 2020-2021 were enrolled. The total detection rate of respiratory viruses was 40.2% in 2018-2019 and 39.9% in 2020-2021. There was a high prevalence of HRV in June-September 2020 (after the reopening of schools), which was higher than the prevalence observed in June-September in 2018 and 2019. The detection rate of RSV decreased sharply in February 2020. After the schools were fully reopened in September 2020, the number of RSV cases gradually increased and peaked in December 2020 and January 2021.From July-September 2021, there was an unexpected mini-peak of RSV. The prevalence of IV decreased significantly after the COVID-19 epidemic, especially IV-A, but there were no significant changes in the age of infection and the epidemic season. HBoV, HMPV, PIV1~3, and ADV showed different degrees of changes in the detection rate and season of infection before and after the COVID-19 epidemic.
Conclusions During the COVID-19 pandemic, the detection rates of common respiratory viruses in Suzhou, southeast China, have changed differently with strict NPIs. Understanding the changes in the detection of respiratory pathogens after the epidemic will help clinicians develop early coping strategies. Key words: COVID-19, children, respiratory viruses, NPIs, viral interference
In silico predicted compound targeting the IQGAP1-GRD domain selectively inhibits growth of human acute myeloid leukemia
Authors: Sahasrabudhe Deepak M. , Liesveld Jane L. , Minhajuddin Mohammad , Singh Niloy A. , Nath Subhangi , Kumar Vishuwes M. , Balys Marlene , Evans Andrew G. , Azadniv Mitra , Hansen Jeanne N. , Becker Michael W. , Sharon Ashoke , Thomas V Kaye , Moore Richard G. , Khera Manoj K. , Jordan Craig T. , Singh Rakesh K. 
Published: April 2023

Abstract

Acute myeloid leukemia (AML) is fatal in majority of adults. Identification of new therapeutic targets and their pharmacologic modulators are needed to improve outcomes. Previous studies had shown that immunization of rabbits with normal peripheral WBCs that had been incubated with fluorodinitrobenzene elicited high titer antibodies that bound to a spectrum of human leukemias. We report that proteomic analyses of immunoaffinity-purified lysates of primary AML cells showed enrichment of scaffolding protein IQGAP1. Immunohistochemistry and gene-expression analyses confirmed IQGAP1 mRNA overexpression in various cytogenetic subtypes of primary human AML compared to normal hematopoietic cells. shRNA knockdown of IQGAP1 blocked proliferation and clonogenicity of human leukemia cell-lines. To develop small molecules targeting IQGAP1 we performed in-silico screening of 212,966 compounds, selected 4 hits targeting IQGAP1-GRD domain, and conducted SAR of ‘fittest hit’ to identify UR778Br, a prototypical agent targeting IQGAP1. UR778Br inhibited proliferation, induced apoptosis, G2/M arrest, and colony formation by leukemia cell-lines and primary-AML while sparing normal marrow cells. IQGAP1/F-actin showed co-localization and UR778Br induced filopodia formation in U937 cells. UR778Br exhibited favorable ADME/T profiles and drug-likeness to treat AML. In summary, AML shows dependency on IQGAP1 and UR778Br, identified through in-silico studies, selectively targeted AML cells while sparing normal marrow.
Providing a multi-objective sustainable distribution network of agricultural items considering uncertainty and time window
Authors: Eshlaghy Abbas Toloie , Daneshvar Amir , Chobar Adel Pourghader 
Published: April 2023

Abstract
In this article, a sustainable network of distribution of agricultural items with suppliers, distribution centers, and retailers is considered. The main purpose of presenting the mathematical model in this article is to determine the optimal number and location of suppliers, assigning suppliers to distribution centers and optimal routing for the distribution of agricultural items to retailers in a predefined time window. Also, determining the optimal amount of inventory and the reorder point in retailers and distribution centers is another problem decision. To model the problem, some parameters of the model were considered non-deterministic and were controlled by the probabilistic fuzzy method. The results of solving numerical examples in different sizes showed that with the increase of the total costs of the distribution network of agricultural items, the amount of greenhouse gas emissions decreases, and the employment rate increases. Also, with the increase of the uncertainty rate, due to the increase of the real demand and the change in the optimal amount of production, distribution, storage and reorder point, the values ​​of all the objective functions also increase. It was also observed by solving different numerical examples with NSGA II and MOGWO algorithms, these algorithms have been able to solve the problem in a much shorter period than the epsilon constraint method, and comparison indicators such as NPF, MSI, SM, and computing time show These algorithms have a high efficiency in solving numerical examples of the problem of the distribution network of agricultural items.
Geochemistry and 14C dating of guano deposits in the Karaftu Cave, Kurdistan, Iran: Implication for palaeoenvironment
Authors: Amin-Rasouli Hadi , Minami Masayo , Armstrong-Altin John , Jou Nasim Haghighat , Moradi Mehdi 
Published: April 2023

Abstract
Karaftu Cave in the northwest of Divandareh includes four floors plus an underground area. The bat hall and its underground area are covered with guano deposits. 14C dating indicates the onset of guano deposition is about 14260±50 BP years, and its average accumulation rate is about 4.1 mm/yr for depths of 360 to 205 cm. Bacterial and fungal metabolisms decay guano, release acids, and disperse large amounts of microorganisms inside the cave. Interactions between acids and guano caused leaching, dissolution, change in the distribution, and abundance of elements, which leads to the formation of secondary minerals in guano. These variations in minerals and elements also depend on the local climatic conditions. Distribution of elements in the Ce/Ce* verse Pr/Pr* diagram and the correlation coefficient between Ce and Mn display three different paleoclimate conditions (dry, wet, and dry) during the accumulation of the guano. Also, dolomite, phosphate, and iron oxide minerals have been formed during the passage of water through bedrock beneath the guano. This water is unsuitable for drinking and harmful to the organisms in the region. Effect of these acids on the substrate also leads to the collapse of the cave floor, generation of a new underground, fall in the groundwater level, change in the groundwater drainage system, drying of springs around the cave, loss of green cover, and a negative impact on the ecosystem in the region. To keep the cave environment clean and remove these problems, it is better to harvest guano and use it as fertilizer.
First-principles study of structure, electrical and magnetic properties of Sc doped armchair Silicene nanoribbons
Authors: Nguyen Thanh Tung 
Published: April 2023

Abstract

In this project, we studying the structural, electrical, and magnetic properties of adsorption of Sc on Armchair Silicene nanoribbons (ASiNRs) in three steps. The first, the hollow position is chosen from four positions bridge, hollow, valley, and top because adsorbed energy is the largest. The second, with the bond length, Si-Si is 2.36 Å, and adsorption energy – 4.18 eV is the best structure state. Finally, the high Sc atom on the surface ASiNRs 1.25 Å was optimized. The result after Sc adsorbed ASiNRs, new materials are semi-metal, they have a magnetic property as candidates for the spintronic device, the electronic device in future.
Changes in attachment patterns in children who were sexually abused during early childhood: A decade of follow-up study
Authors: Tsang Vionna M. W. , Duin Esther M. , Abrahamse Marielle E. , Gigengack Maj R. , Brilleslijper-Kater Sonja N. , Verhoeff Arnoud P. , Jonkman Caroline S. , Noom Marc J. , Lindauer Ramon J.L. , Verlinden Eva 
Published: April 2023

Abstract

Background The quality of parent–child attachment is one of the essential factors related to the possible outcomes in the aftermath of child sexual abuse (CSA). The types of attachment insecurity are well-known, as are its mediating effects on CSA and the other way around. However, one of the main issues relating to what we know about the long-term development of those attachment patterns is the aftermath of CSA in very young children. Our study is part of the larger, ongoing Amsterdam Sexual Abuse Case (ASAC) study. It provides new insights into the existing scientific literature because it concerns an exceptional study population consisting of extrafamilial sexual abuse, juridical proof of the sexual abuse, the extremely young age at the time of onset, and it provides insight into attachment patterns over a period of more than 10 years after CSA.Methods We have aimed to look into the parent–child attachment relationship in a unique group of children who have been sexually abused at a very young age (0–3 years old) using parent-report questionnaires over a period of a decade: from the start of the study 3 years after the disclosure of CSA until 13 years after CSA.Results These longitudinal results show fluctuations in reported attachment insecurity levels over the years. From 10 years after CSA and thereafter, we found levels of attachment insecurity to have decreased. Nevertheless, all children between 10 years after CSA and 13 years after CSA showed clinical levels of attachment insecurity.Conclusions To conclude, insecure attachment patterns in the aftermath of CSA appear to apply to children who were sexually abused during infancy or early childhood, even if the perpetrator is not a primary caregiver. Additionally, the results indicate the importance of long-term monitoring for children as well as their parents not only in the treatment of symptoms but also in terms of family support and parent–child attachment. Further longitudinal and multi-informant studies are needed to elucidate these results.
Cost drivers and financial burden for cancer-affected families in China: a systematic review
Authors: Jia Yufei , Jiang Weixi , Yang Bolu , Tang Shenglan , Long Qian 
Published: April 2023

Abstract
Background: Cancer has been the leading cause of death in China and imposes heavy burdens on individuals and the health system. China’s cancer control plan includes efforts to mitigate financial hardship for the affected households in the context of ongoing health system reform. However, evidence is limited about how the affected families afford cancer care.
Methods: This systematic review is to map medical, non-medical, and indirect costs incurred by cancer care, the financial burden for patients, and their economic coping strategies from 2009 onwards. We included original quantitative studies conducted in mainland China that reported out-of-pocket payment for cancer care and patients’ coping strategies in English or Chinese We searched PubMed, Embase, Ovid, Web of Science, Cochrane and two Chinese databases (CNKI and WanFang Data) from January 1st 2009 to 10th August 2022. We introduced ten quality criteria for quality assessment of the included studies according to the standards for reporting observational studies. We reported components of costs and coping strategies narratively and presented costs as a percentage of household income.
Results: Annual mean medical costs (including inpatient and outpatient costs and fees for self-purchasing drugs) ranged from US$7421 to US$10297 (an unweighted average of US$8794) per patient. In a study that investigated medical costs for five years, inpatient costs accounted for 51.6% of total medical costs, followed by self-purchasing drugs (43.9%). The estimation of non-medical and indirect costs varied considerably. Annual medical costs as a percentage of annual household income ranged from 36.0% to 63.1% with a meta-proportion of 51.0%. The common coping strategies included borrowing money, reduction of household expenses and expenses from basic health services.
Conclusions: Costs of inpatient care and self-purchasing drugs are major drivers of medical costs for cancer care, and many affected households shoulder a very heavy financial burden. This will require strengthening stewardship for cancer control and multi-sector cooperation to mitigate the risk of financial hardship.
Autophagy and nuclear morphometry are associated with histopathologic features in esophageal squamous cell carcinoma
Authors: Iserhard Ricardo , Pilar Emily Ferreira Salles , Hehn Francine , Callegari-Jacques Sídia Maria , Ferst Paula , Visioli Fernanda , Lopez Patrícia Luciana da Costa , Filippi-Chiela Eduardo 
Published: April 2023

Abstract
Less than 15% of patients with esophageal squamous cell carcinoma (ESCC) survive five years after the diagnosis. A better understanding of the biology of these tumors and the development of clinical biomarkers is necessary. Autophagy is a physiological mechanism involved in the turnover of cellular components, playing critical roles in cancer. In this study, we evaluated the differential levels of three major autophagy regulators (SQSTM1, MAP1LC3B, and BECN1) in ESCC patients. We associated autophagy with histopathologic features, including the differentiation grade, mitotic rate, inflammation score, and the intensity of tumor-infiltrating lymphocytes. We also assessed the nuclear morphometry of the tumor parenchyma and associated it with autophagy and histopathology. The three markers were significantly increased in ESCC in comparison to control. Based on the mean expression of each protein in the control group, 57% of ESCC patients showed high levels of the three markers, compared to 14% in controls. The most frequent profiles found in ESCC were BECNhigh/MAP1LC3high and BECNhigh/SQSTM1high. Using the TCGA database, we found that the autophagy is upregulated in ESCC. Furthermore, high levels of autophagy markers were associated with poor prognosis. Considering the nuclear morphometry, ESCC samples showed a significant reduction in nuclear area, which strongly correlated negatively with autophagy. Finally, the percentage of normal nuclei was associated with tumor differentiation, while lower levels of SQSTM1 were observed in poorly differentiated tumors. We found that the ESCC progression may involve an increase of autophagy and alterations in the nuclear structure, associated with clinically relevant histopathological features.