bluuebunny/crossref_metadata_2025_split huggingface dataset:
Endovascular treatment of multilevel brachiocephalic artery lesions in asymptomatic patients: a case series
Authors: Vanyurkin A.G. , Soboleva A.V. , Susanin N.V. , Belova Yu.K. , Soloviev V.A. , Chernyavskiy M.A. 
Published: December 2022

Objective: To evaluate the outcomes of complete endovascular carotid revascularization in asymptomatic patients with tandem lesions of common carotid arteries (CCA) and internal carotid arteries (ICA) and to demonstrate the endovascular technique.Methods: Endovascular treatment of two-level brachiocephalic artery lesions was performed in 23 patients at the Almazov National Medical Research Centre from 2017 to 2022. The mean age of the patients was 71.3 years. The lesions were localized in the left CCA and ICA in 11 patients, in the right CCA and ICA in 7 patients, and in the brachiocephalic trunk and right ICA in 5 patients. All patients were asymptomatic on the affected side. Results: Completed with successful stent implantation, all the procedures were effective, with no complications at the access site (hematoma, dissection, bleeding) and no perioperative mortality or residual stenoses. Postoperative neurological disorders developed in two patients including ipsilateral neurological symptoms (NIHSS score 4, Rankin score 1) in one of them and moderate aphasia and dysarthria NIHSS score 2, Rankin score 1) in the other. Brain MSCT showed signs of ischemic stroke that did not require any additional surgical treatment in the second patient. Following the rehabilitation, the neurological symptoms regressed. The mean hospital stay was 4 days. Two years after the intervention two patients required reintervention, i.e. repeat angioplasty of the ICA stent, due to in-stent restenosis.Conclusion: The outcomes in a series of patients with tandem brachiocephalic artery lesions indicate the efficacy of complete endovascular intervention with good short-term results.
Received 23 June 2022. Revised 31 July 2022. Accepted 23 August 2022
Informed consent: The patient’s informed consent to use the records for medical purposes is obtained.
Funding: The study did not have sponsorship.
Conflict of interests: Authors declare no conflict of interest.
Contribution of the authorsLiterature review: A.V. Soboleva, V.A. SolovievDrafting the article: A.G. Vanyurkin, Yu.K. BelovaCritical revision of the article: M.A. ChernyavskiySurgical treatment: M.A. Chernyavskiy, A.G. Vanyurkin, N.V. SusaninFinal approval of the version to be published: A.G. Vanyurkin, A.V. Soboleva, N.V. Susanin, Yu.K. Belova, V.A. Soloviev, M.A. Chernyavskiy
Terapia cognitivo-comportamental como recurso no tratamento do luto diante de morte repentina
Authors: Pontes Ferreira Alves Diego , Jordão Laport Tamires 
Published: December 2022

Embora a morte seja um evento natural e inevitável, sua ocorrência é promotora de estresse, dor e sofrimento, sobretudo quando esta ocorre de forma repentina. Vivenciar o processo do luto é normal e experimentar suas etapas e fases de maneira saudável é essencial para a reestruturação do enlutado. No entanto, no processo do luto podem ocorrer desordens emocionais e psíquicas que dificultam que este retome a sua vida normal, podendo-o paralisar; circunstância em que recorrer ao auxílio terapêutico torna-se indispensável para que a sintomatologia do luto não se agrave evoluindo para o luto complicado. Neste contexto, a presente pesquisa teve como objetivo discutir sob a perspectiva da abordagem cognitivo-comportamental quais os recursos no tratamento do luto por morte repentina. A pesquisa de cunho qualitativo exploratório desenvolver-se-á fundamentada em referencial teórico, constante da análise de livros e artigos acadêmicos disponíveis em bases de dados científicas sobre o tema proposto e com a TCC como tratamento adequado no alívio dos sintomas do luto.

Palavras-chave: Enlutado. Luto por morte. Psicólogo. Terapia cognitivo-comportamental.
Nitrogen-containing Fused Heterocycles: Organic Synthesis and Applications as
Potential Anticancer Agents
Authors: Ledade Pankaj V. , Lambat Trimurti L. , Gunjate Jitendra K. , Chopra Paavan K.P.G. , Bhute Amitkumar V. , Lanjewar Mamata R. , Kadu Pooja M. , Dongre Utpal J. , Mahmood Sami H. 
Published: December 2022

Abstract:
The fused Nitrogen heterocyclic compounds and their derivatives have grown in
prominence over the past several decades as a result of their significant medical value. The
adaptable and easily synthesized N-Heterocyclic scaffolds are particularly exciting in both
synthetic organic chemistry and the biological sector due to their powerful pharmacological
properties, which are taken into consideration while considering their numerous uses. For the
synthesis of N-heterocycles and their derivatives, several attempts were undertaken to create a
variety of synthetic protocols. The N-Heterocyclic compounds provide a variety of adaptable
structures for specific biological applications and represent novel, broad-spectrum antibacterial
and anticancer agents. They typically have minimal toxicity profiles. The majority of these
N-Heterocycles have demonstrated more cytotoxicity than the effective anticancer medication
cisplatin. The design, synthesis, structural characterisation, and biological uses of N-Heterocycles are reviewed
in this work. In this article, the developments made in this specific field are comprehensively examined.
Time- and Concentration-Dependent Stimulation of Oxidative
Stress in Chondrocytes by Intracellular Soluble Urate
Authors: Zhang Bingqing , Di Hong , Zhang Yun , Han Xinxin , Yin Yue , Han Yingdong , Cao Yu , Zeng Xuejun 
Published: December 2022

Background:
Gout could result in irreversible bone erosion, and chondrocyte
might be involved in the process. Increased soluble urate is the early stage of
gout and is strongly oxidative.

Objective:
To explore the effect of intracellular urate on the oxidative status of chondrocytes

Methods:
A chondrocyte model was used. Serial concentrations of exogenous urate
were incubated with chondrocytes for increasing amounts of time. Reactive oxygen
species (ROS), oxidant, and anti-oxidant molecules were measured with biochemical
assays, rt-PCR, and western blot. A urate transport inhibitor and oxidative inhibitors
were used to confirm the effect of exogenous urate.

Results:
All concentrations of exogenous urate stimulated the production of ROS in a
time- and concentration-dependent manner, as well as oxidant molecules, including
hydrogen peroxide (H2O2), nicotinamide adenine dinucleotide phosphate (NADPH)
oxidase, nitric oxide (NO) inducible nitric oxide synthase (iNOS), and these effects,
could be inhibited by oxidant inhibitors. However, anti-oxidant molecules, including
acidic leucine-rich nuclear phosphoprotein-32A (ANP32A), ataxia-telangiectasia mutated
(ATM), heme oxygenase-1 (HO-1), and the transcription factor nuclear factor
erythroid 2 (NF-E2)-related (Nrf2), was decreased by high concentrations of exogenous
urate after prolonged incubation, but not by low to medium concentrations of
exogenous urate. By inhibiting soluble urate trafficking, benzbromarone significantly
suppressed the effect of urate stimulus on the oxidant and anti-oxidant molecules.

Conclusion:
Intracellular soluble urate could regulate chondrocyte redox balance in a
time and concentration-dependent manner, and would be a target for regulating and
protecting chondrocyte function in the early gout stage.
Facial Palsy Induced by Covaxin in Adolescent Female - A Rare Case Report
Authors: Chaudhari Priyanka Jivrambhai , Chawda Uditkumar Bhupeshkumar , Bhad Bhagirath Jayantilal , Mevada Ashvin Vasantlal , Jha Sushilkuamar Gopikant 
Published: December 2022

Background:
The world has seen nearly 2 years of a pandemic caused by the SARS-CoV-2
virus, notoriously known as COVID-19. Several vaccines have been approved under Emergency Use
Authorization (EUA) to combat the disease, one of which is Covaxin, an inactivated adjuvant SARSCoV-
2 vaccine that is generally well tolerated and has fewer side effects. However, we recently have
seen a rare case of facial palsy (paralysis) following Covaxin vaccination in an adolescent girl.

Case Presentation:
A 16 years old adolescent girl presented with chief complaints of left side deviation
of mouth with difficulty in closing right eye after 29 days of receiving the first dose of Covaxin,
which was finally diagnosed as a "Covaxin induced facial palsy". Her symptoms were alleviated
with some supportive measures, steroid and antiviral treatment, with full recovery.

Conclusion:
The case depicts facial nerve paralysis following Covaxin use, possibly the first of its
kind. This case illustrates plausible explanation to Covaxin use and occurrence of facial palsy,
however, further studies required to establish causal relationship.
Studies on Montmorillonitic (Bentonite) Clay of Western Kazakhstan as a Therapeutic Mineral Feed Additive for Quails
Authors: Montayeva Nurgul S. , Montayev Sarsenbek A. , Montayeva Aruzhan S. 
Published: December 2022

Background:
The paper presents the findings of a broad analytical review of the use of bentonite clays as a mineral feed additive in poultry farming in order to increase productivity and prevent diseases. It has been shown that an important direction in improving the technology of veterinary preventive measures is the introduction of new methods for the prevention and treatment of diseases in quails with the use of drugs with bioactive properties that can have a regulatory effect on the intensity of metabolic processes and enhance the functional activity of organs and body systems. The emphasis is placed on the unique properties of bentonite as high adsorption, catalytic, and ion-exchange activity.

Methods:
Using the comparison method, the authors studied preliminary studies of the chemical and mineralogical composition of the montmorillonite clay of the Pogadaevsky deposit of the West Kazakhstan region. The method of scanning electron microscopy was used to determine the local elemental composition of the provided samples. The mass spectrometry method was used to determine the chemical elemental composition. In addition, the X-ray diffractometry method was used to determine the mineralogical composition.

Results:
According to the results of scientific and experimental research, it was established that the studied clay has a significant sorption activity.

Conclusion:
The first scientific experiments on the effect of bentonite-like (montmorillonite) clay on the egg production of quails showed its significant effectiveness.
Interrater Agreement on National Institutes of Health Stroke Scale Between Paramedics and Stroke Physicians: Validation Study for the Digital Training Model in the Paramedic Norwegian Acute Stroke Prehospital Project
Authors: Guterud Mona , Bugge Helge Fagerheim , Røislien Jo , Larsen Karianne , Eriksen Erik , Ingebretsen Svein Håkon , Mikkelsen Martin Lerstang , Kramer-Johansen Jo , Bache Kristi G , Sandset Else Charlotte , Hov Maren Ranhoff 
Published: December 2022

Background
Time spent in the prehospital phase of acute stroke care is multifactorial and has an effect on the possibilities for acute treatment. Communication between paramedics and the in-hospital stroke team directly affects time to treatment. A mutual stroke scale such as the National Institutes of Health Stroke Scale (NIHSS) may improve communication quality. The Paramedic Norwegian Acute Stroke Prehospital Project (ParaNASPP) was a stepped-wedge, randomized trial of stroke screening using NIHSS in the ambulance where the intervention was training paramedics in stroke and the NIHSS, with the use of NIHSS made into a mobile app to guide the examination and facilitate communication with the in-hospital stroke team.

Objective
The aim of this study was to validate the digital training model from the ParaNASPP clinical trial.

Methods
In total, 24 paramedics were recruited from Oslo University Hospital in Norway to complete the ParaNASPP training model; 20 exclusive videos with predefined NIHSS scores were recorded; and 4 stroke physicians from Oslo University Hospital were included for reference. Bland-Altman plots with 95% limits of agreement (LoA) were calculated—first comparing paramedics and stroke physicians to the predefined scores and then with each other. The predefined LoA were set to 3 points. To align with clinical practice, NIHSS scores were also dichotomized into 2 categories: from 0-5 (minor stroke) or ≥6 (moderate and major stroke), and agreement was calculated using Cohen κ.

Results
The videos (n=20) had a median (range) NIHSS score of 7 (0-31). The paramedics’ scores were slightly higher than the predefined scores with a mean difference of –0.38 and the LoA ranging from –4.04 to 3.29. The paramedics scored higher than the stroke physicians with a mean difference of –0.39, with the LoA ranging from –4.58 to 3.80. When the NIHSS scores were dichotomized, Cohen κ was 0.89 between the predefined scores and paramedics, 0.92 between the predefined scores and stroke physicians, and 0.81 between the paramedics and stroke physicians, all indicating very good agreement.

Conclusions
The paramedics scored higher than both the predefined scores and stroke physicians’ scores, hence the predefined LoA were not met. However, the width of the LoA was smaller than seen when experienced neurologists are compared. When the NIHSS scores were dichotomized, the paramedics achieved very good agreement with both the predefined scores and stroke physicians’ scores. This study demonstrates the possibilities for the transfer of clinical competence in digital simulation training.
Design Innovation for Engaging and Accessible Digital Aphasia Therapies: Framework Analysis of the iReadMore App Co-Design Process
Authors: Langford Tom , Fleming Victoria , Upton Emily , Doogan Catherine , Leff Alexander , Romano Daniela M 
Published: December 2022

Background
iReadMore is a digital therapy for people with acquired reading impairments (known as alexia) caused by brain injury or neurodegeneration. A phase II clinical trial demonstrated the efficacy of the digital therapy research prototype for improving reading speed and accuracy in people with poststroke aphasia (acquired language impairment) and alexia. However, it also highlighted the complexities and barriers to delivering self-managed therapies at home. Therefore, in order to translate the positive study results into real-world benefits, iReadMore required subsequent design innovation. Here, we present qualitative findings from the co-design process as well as the methodology.

Objective
We aimed to present a methodology for inclusive co-design in the redesign of a digital therapy prototype, focusing on elements of accessibility and user engagement. We used framework analysis to explore the themes of the communications and interactions from the co-design process.

Methods
This study included 2 stages. In the first stage, 5 in-person co-design sessions were held with participants living with poststroke aphasia (n=22) and their carers (n=3), and in the second stage, remote one-to-one beta-testing sessions were held with participants with aphasia (n=20) and their carers (n=5) to test and refine the final design. Data collection included video recordings of the co-design sessions in addition to participants’ written notes and drawings. Framework analysis was used to identify themes within the data relevant to the design of digital aphasia therapies in general.

Results
From a qualitative framework analysis of the data generated in the co-design process, 7 key areas of consideration for digital aphasia therapies have been proposed and discussed in context. The themes generated were agency, intuitive design, motivation, personal trajectory, recognizable and relatable content, social and sharing, and widening participation. This study enabled the deployment of the iReadMore app in an accessible and engaging format.

Conclusions
Co-design is a valuable strategy for innovating beyond traditional therapy designs to utilize what is achievable with technology-based therapies in user-centered design. The co-designed iReadMore app has been publicly released for use in the rehabilitation of acquired reading impairments. This paper details the co-design process for the iReadMore therapy app and provides a methodology for how inclusive co-design can be conducted with people with aphasia. The findings of the framework analysis offer insights into design considerations for digital therapies that are important to people living with aphasia.
Electrochemical Behaviour of Silica Deposited on Stainless Steel by Electrophoretic Deposition
Authors: Putri Suari Ni Made Intan , Ratnasari Delyana , Tulaini Sahara , Widiyastuti W. , Setyawan Heru 
Published: December 2022

The purpose of this paper is to evaluate the characteristics of corrosion protection of stainless steel substrates coated with silica by electrophoresis with pulsed direct current (PDC) and constant direct current (CDC) with anodization. Electrophoresis was carried out using silica sol from sodium silicate solution as an electrolyte solution. Stainless steel functioned as an anode and carbon as a cathode with a constant electrode distance of 2 cm. The amplitude, duty cycle, and anodization effect on stainless steel corrosion protection characteristics were evaluated. The samples were characterized by linear polarization and electrochemical impedance spectroscopy (EIS) to see the characteristics of metal corrosion protection and scanning electron microscopy (SEM) analysis to see the morphology of the coating. This study showed that PDC electrophoresis and CDC accompanied by anodization could obtain silica film with good corrosion protection characteristics (high pore resistance and low admittance). Linear polarization results showed that metal corrosion protection behavior was increased by anodization. Similar results were obtained by EIS analysis which showed that pore resistance increased by anodization. The highest pore resistance obtained by the constant current with anodization is 543 ohms, and the lowest admittance is 0.0217. Corrosion protection characteristics are also influenced by the amplitude and duty cycle during electrophoresis. Silica film with a high pore resistance and a low admittance were obtained at a frequency, amplitude, and duty cycle of 80 Hz, 0.5 volts, and 60%, respectively. The silica film produced by pulsed electrophoresis resulted in better coating characteristics than by constant current with anodization, which is seen from the pore resistance value and its admittance.
Characterization of Cellulose Acetate Membrane at Different Thicknesses on Sucrose Concentration by Forward Osmosis
Authors: Idris Aida I. Mohamad , Mustapa Kamal Siti Mazlina , Sulaiman Alifdalino , Omar Rozita , Mohammad Munira 
Published: December 2022

Forward osmosis (FO) requires a specific membrane structure for applications like juice concentration. The phase inversion method was used to make cellulose acetate (CA) FO membranes. The solvents used were acetone and 1,4-dioxane. Additives included polyvinylpyrrolidone (PVP), methanol, and maleic acid were used in the preparation of CA membrane, which make it easier to improve a FO membrane's permeability. The performance of fabricated FO membrane and their morphology were evaluaed with different casting thicknesses of 150, 200, and 250 µm. Experiment works begins with an hour of membrane flux testing, deionized water was used as feed solution and 1 M NaCl as draw solution. The membrane was then used to concentrate 0.5 M sucrose with NaCl for 240 minutes (2 M). Contact angle, porosity, and scanning electron miscroscopy (SEM) were used to characterize membrane properties and morphology. High water flux (2.25 L/m2hr) and high porosity (75.86%) were found at 200 µm casting thickness. Water permeability of sucrose concentration at 200 µm casting thickness had the highest flux (2.39 L/m2hr). The results also show that flux values vary with membrane thickness. All membranes were hydrophilic with contact angles below 90°. A 200 µm casting thickness produces a membrane with smooth and evenly distributed pores, according to morphology analysis. Structural parameter (S) values had a proportional relationship with the FO membrane thickness, which thinner membrane potentially reduces the internal concentration polarization (ICP).
Gravidade do pé diabético: fatores socioeconômicos em estudo envolvendo 5.300 operados
Authors: Amorim Alanna da Silva , Machado Camila Leite , Souza Victoria Luísa Alencar Rocha de , Carvalho Aquiles Tadashi Ywata de , Santos Aleksandro de Jesus , Queiroz Márcio Oliveira de 
Published: December 2022

As amputações decorrentes de pé diabético são graves e geram impacto social e econômico, porém são passíveis de prevenção. O objetivo deste estudo foi testar a hipótese de que há associação entre fatores socioeconômicos e a gravidade do pé diabético. Em estudo observacional restrospectivo, foram avaliados 5.300 prontuários de pacientes portadores de pé diabético operados pelo Serviço de Cirurgia Vascular do Hospital Geral Roberto Santos (HGRS), no período de fevereiro de 2005 a dezembro de 2015. Foram coletadas as condições socioeconômicas para verificar correlação com a gravidade do pé diabético. Os dados foram tabulados no Excel e a distribuição foi analisada no GraphPad Prism 8.0, por meio do teste qui-quadrado e da técnica de regressão logística. Foram considerados valores de p < 0,05 como estatisticamente significantes. A maioria dos pacientes era de meia-idade (entre 53 e 58 anos), do sexo masculino (57,58%), com o ensino fundamental completo (50,38%) e ganhava menos de um salário mínimo (56,81%). A principal doença associada foi a hipertensão arterial sistêmica (HAS) (55,64%). Com relação à distância, foi observado que 48,15% residiam a menos de 100 km da unidade hospitalar. Observou-se prevalência de amputação menor (37,36%) e taxa de letalidade de 6,32%. Também foi possível correlacionar, quanto à amputação maior, maiores frequências nos pacientes acima de 70 anos (p = 0,045), naqueles com renda familiar abaixo de um salário mínimo (p = 0,05), nos portadores de doença arterial coronariana (Daop) (p = 0,035) e nos indivíduos que residiam a uma distância acima de 400 km do HGRS. Registrou-se maior taxa de óbito nos portadores de coronariopatia, com idade superior a 70 anos e nos submetidos à amputação maior. Diante disso, faz-se necessário treinamento de profissionais e adoção de medidas de saúde pública, visando identificar precocemente a população de maior gravidade, a fim de evitar desfechos desfavoráveis.
Modos de presença na arte contemporânea
Authors: Rocha Rizzia Soares 
Published: December 2022

O espaço expositivo institucional interfere não só na recepção da obra de arte, mas na apresentação e produção dos trabalhos. A discussão desenvolvida nesse artigo se concentra nas críticas ao espaço expositivo modernista, o cubo branco, que assume o estatuto de modelo expositivo hegemônico com a crescente proeminência dos Estados Unidos nas artes. Essa crítica modifica os modos de presença na arte ao integrar o espaço aos trabalhos fazendo dele uma poética. Para esse percurso de análise, as décadas de 1960 e 1970 são privilegiadas aqui através da arte minimalista, embora na mesma época outras formas de crítica ao espaço institucional tenham surgido. Esse artigo integra o trabalho do grupo de pesquisa “Modos de presença dos fenômenos estéticos”.