bluuebunny/crossref_metadata_2025_split huggingface dataset:
THE EARLY RECEPTION OF APULEIUS: AN ECHO IN TERTULLIAN
Authors: Grillo Luca 
Published: January 2023

AbstractApuleius tells us of his own popularity as a writer, and yet both the literary and the material records are silent about his works for almost one hundred and fifty years after his death. Various attempts to identify allusions to his works before Lactantius and other fourth-century authors have proven unconvincing. This article suggests that there is a clear allusion to theMetamorphosesin Tertullian's treatiseAduersus Valentinianos(beginning of the third century). Tertullian uses Apuleius to denigrate the Valentinians and to assimilate the name of one of their gods to the braying of an ass.
Navigating the pitfalls of language standardisation: The imperfect binary of authenticity and anonymity in Creole-speaking Martinique
Authors: Ardoino Chiara 
Published: January 2023

AbstractStandardisation is often touted as the default means to improve attitudes towards minoritised languages and prevent/reverse their obsolescence. However, standardisation can ‘tamper’ with the indexicalities of minoritised languages, potentially alienating their speakers. Two aspects of standardisation stand out as particularly problematic: the shift from ‘ideologies of authenticity’ to ‘ideologies of anonymity’ (Woolard 2016), and the resulting introduction/intensification of prescriptivism (Eckert 1983). Although much literature focuses on the irreconcilable nature of these ideologies, I show that their discursive manifestations are neither clear-cut nor always incompatible. First, I analyse a TV debate on the standardisation of Martinican Creole (MC), in which the fault-line between authenticity and anonymity is blurred and partially overcome. Next, I draw on a Martinican activist's Instagram profile to show how various discursive strategies and a positive take on language variation can help promote MC as an ‘anonymous’ language without forgoing its ‘authenticity’ or openly stigmatising spontaneous practices. (Minoritised languages, Creoles, Martinique, maintenance, standardisation, ideologies of authenticity, anonymity, prescriptivism, purism, Abstand)*
NLP startup funding in 2022
Authors: Dale Robert 
Published: January 2023

AbstractIt’s no secret that the commercial application of NLP technologies has exploded in recent years. From chatbots and virtual assistants to machine translation and sentiment analysis, NLP technologies are now being used in a wide variety of applications across a range of industries. With the increasing demand for technologies that can process human language, investors have been eager to get a piece of the action. In this article, we look at NLP startup funding over the past year, identifying the applications and domains that have received investment.
Frontiers of astrobiology and the humanities
Authors: Chela-Flores Julian 
Published: January 2023

AbstractOne of the main objectives of astrobiology is to understand the distribution of life in the universe, for microbial life, as well as for the search of extra-terrestrial intelligence, both of which would force upon us new problems in philosophy, including ethics and theology. The question of astrobiology and the humanities being such a broad topic, in the present paper we have limited our discussion of the Frontiers of Astrobiology and the Humanities to the single topic: ‘Independence of science (astrobiology) from philosophy and theology’. We have argued along the lines of this narrower thesis, but restricting our theological discussion strictly to a Judeo-Christian perspective.
Patient and family members’ experiences with language and environment when receiving bad news: A qualitative exploratory study
Authors: Miller Elizabeth M. , Porter Joanne E. , Barbagallo Michael S. 
Published: January 2023

AbstractObjectivesReceiving bad news about one’s health can be devastating, yet little is known about how the therapeutic nature of the environment where bad news is delivered affects the experience. The current study aimed to explore how patients and their families were affected by the language and the built, natural, social, and symbolic environments when receiving bad news, through the Therapeutic Landscapes theoretical framework.MethodsPatients diagnosed with a life-limiting illness living in regional Victoria who had a hospital admission within 24 months and a diagnostic/prognostic conversation were invited to participate, as well as a family member who witnessed the conversation. Participants were recruited through social media and snowballing, resulting in 14 online semi-structured interviews being conducted between November 2021 and March 2022, audio-recorded, and transcribed verbatim. Reflexive thematic analysis was used to develop the themes.ResultsFourteen semi-structured interviews were conducted with women aged between 30 and 77 years. Interviews lasted between 45 and 120 minutes, with an average of 69 minutes, and were conducted online or via mobile phone. Four central themes were developed: “Hearing bad news for the first time,” “Preferences for having hard conversations,” “Creating a sense of safety for ongoing care,” and “The therapeutic nature of the ward.”Significance of resultsThis body of work will help inform practice and future policy regarding bad news delivery and the design and aesthetics of environments where bad news is delivered. It is essential that bad news is delivered within a quiet, calm, and emotionally safe environment within a supportive therapeutic relationship.
The Edizione critica delle opere di Gioachino Rossini and Self-Borrowing
Authors: Malnati Andrea 
Published: January 2023

Self-borrowing and Rossini: music theatre scholars are well acquainted with this topic. Many publications have been dedicated to it, most of which concentrate on compositional-analytic aspects, the artistic and communicational nature of self-borrowing and its reception in nineteenth-century periodicals. At present, however, no study has attempted to question the relation between Rossini's self-borrowings and the critical edition of his works. This is the issue to which this contribution is dedicated.
Beginning with the operating indications summarized by the editorial criteria provided for the Edizione critica delle opere di Gioachino Rossini – first published in 1974, and revised and updated in 2015 – this study compares the various methodological approaches adopted while preparing critical editions and dealing with the specific features of each passage in which self-borrowing appears. This comparison furthermore allows us to formulate a general overview of the entire editorial undertaking. This in turn will give us a glimpse of how principles such as the autograph's centrality and concepts such as authenticity and originality have often become problematic and have been put into question. Knowing that Rossini often rewrote the pieces he self-borrowed is fundamental for philologists working on the critical edition of his works. Decoding the modus operandi Rossini adopted in each case of self-borrowing is therefore equally important, and can help choose the sources closest to Rossini's idea of the self-borrowed pieces at the time of their reuse.
Drift Corrected Seafloor Pressure Observations of Vertical Deformation at Axial Seamount 2018–2021
Authors: Sasagawa Glenn S. , Zumberge Mark A. , Cook Matthew J. 
Published: January 2023

AbstractAxial Seamount is a seafloor volcano with frequent eruptions and periodic cycles of inflation and deflation. Seafloor pressure gauges monitor vertical deformation with time, but inherent instrumental drift complicates and biases geodetic interpretation. A drift corrected pressure recorder was deployed on Axial Seamount on 6 July 2018, at coordinates 45° 57.29′ North latitude, −130° 0.56′ East longitude, depth 1,535 m. This system includes two independent quartz‐resonant pressure gauges, which nearly continuously observe the seafloor pressure. At regular intervals, the gauges are calibrated in situ with a modified deadweight tester at a pressure within 98% of the nominal seafloor pressure. Using the calibration data, the drift of each gauge has been modeled as a simple linear plus decaying exponential function of time. The two estimated linear sensor drift rates are 0.45 ± 0.12 and 0.36 ± 0.08 kPa/year; the modeled sensor drift represents a significant error if uncorrected. The standard deviations of the drift model residuals are of order 0.06 kPa or 6 mm depth equivalent. Once calibrated, the difference between the two seafloor pressure timeseries exhibits a RMS deviation of ±6 mm at the 90% confidence limit and a linear trend less than 1 mm/year. A time series from July 2018 to December 2021 tracks the inflation of Axial Seamount with differing inflation rates over different time intervals.
A Novel Approach to Quantify Sediment Transfer and Storage in Rivers—Testing Feldspar Single‐Grain pIRIR Analysis and Numerical Simulations
Authors: Guyez Anne , Bonnet Stéphane , Reimann Tony , Carretier Sébastien , Wallinga Jakob 
Published: January 2023

AbstractQuantifying sediment transport and storage in fluvial systems is fundamental for understanding the transfer of eroded materials from source to sink. Here, we investigated the potential of a combined approach using a luminescence measured in modern fluvial sediments and numerical simulations to quantify transport and storage in rivers. We acquired luminescence data at the single‐grain scale on feldspar sediments of Waimakariri and Rakaia braided rivers (New Zealand) using a post infra‐red infra‐red stimulated luminescence protocol. We considered three metrics from the analysis of luminescence equivalent dose (De) distribution: the percentage of bleached and the percentage of saturated grains, and the meanDe. All three metrics show similar longitudinal trends along both rivers. To derive quantitative information on sediment transfer from these data, we developed a numerical model that simulates the longitudinal evolution ofDedistribution of a population of grains during transport and storage in floodplains. The model considers four main parameters: the transport length of grains during floods, their resting time between successive transport events, the bleaching probability (probability of the luminescence signal to be reset due to sunlight exposure during transport or rest), and the likelihood of partial bleaching. Identification of model parameters that best reproduce natural observations allowed estimating transit time of sediments between 2.1 and 10.3 Kyr (mean of 6.9 2.9 Kyr), corresponding to mean virtual transit velocity of 20–95 m.yr−1(mean of 46 28 m.yr−1). Our study illustrates the potential of the combined single‐grain luminescence and modeling approach to quantify sediment transfer in fluvial systems.
Late Miocene to Present Paleoclimatic and Paleoenvironmental Evolution of the South China Sea Recorded in the Magneto‐Cyclostratigraphy of IODP Site U1505
Authors: Nie Yunfeng , Wu Huaichun , Satolli Sara , Ferré Eric C. , Shi Meinan , Fang Qiang , Xu Ye , Zhang Shihong , Li Haiyan , Yang Tianshui 
Published: January 2023

AbstractThe continuous sedimentary cores recovered at the International Ocean Discovery Program (IODP) Site U1505, Expedition 368, provide an opportunity for paleoceanography and paleoclimate reconstruction in the continental margin of the northern South China Sea (SCS). In this study, we conducted detailed rock‐ and paleomagnetic studies on 420 discrete samples from the top ∼200 m of the synthetic records of Holes U1505C and U1505D. Rock magnetic analyses indicate that low‐coercivity pseudosingle domain magnetite dominates as the primary ferromagnetic mineral of Site U1505. The magnetostratigraphic age model was constructed by correlating the interpreted polarity sequence with the Geomagnetic Polarity Time Scale 2020 with the constraints of the biostratigraphic data and the distribution probability of the age of each polarity zone provided by a Dynamic Time Warping algorithm. The Milankovitch cycles of the short eccentricity, obliquity, and precession cycles were identified in the magnetic susceptibility (MS) and natural gamma radiation (NGR) series based on paleomagnetic results. We established an ∼9 Myr high‐resolution astronomical time scale by tuning the MS and NGR records to the global oxygen isotope curves, the obliquity, and the eccentricity curves of the La2004 astronomical solution. Our new age model reveals detailed sedimentation rate variations and a ∼500 kyr hiatus across the Brunhes‐Matuyama boundary related to local tectonic activity. These results lay the foundation for understanding the paleoceanography and paleoclimate evolution of the SCS.
Origin of Late Triassic Granitoids of the Coastal Cordillera of Southern Central Chile (34°–37°S): Multi‐Isotopic Evidence of Slab Tearing Effects on Pre‐Andean Magmagenesis
Authors: Rossel Pablo , Gianni Guido M. , Reinoso Valeria , Fanning C. Mark , Ducea Mihai N. , Muñoz Tamara , Salvat Daniela 
Published: January 2023

AbstractThe Coastal Cordillera of Central Chile (34°–37°S) holds a series of Late Triassic granitoids classically interpreted as early Andean subduction‐related magmatism based on their arc‐like geochemical signature. Here, we present geochemical, isotopic, and geochronological data and a tomotectonic analysis that challenge this idea indicating a local interruption of the normal subduction process likely associated with a slab‐tearing event. Our results suggest that the source of the magmas is related to melting of asthenospheric mantle and crustal rocks of a metasedimentary Paleozoic complex. We suggest that partial melting of these sources was triggered by a slab tear‐related asthenosphere upwelling producing high‐silica S/I‐ and S‐Type granites of the Constitución and Hualpén areas, and anorogenic A‐Type granitoids in Cobquecura area. Also, partial melting of a metasomatized asthenospheric mantle plus continental crust that experienced previous high‐temperature hydrothermal alteration would have generated high‐silica magmas with low δ18O, high Pb, CHUR‐like 87Sr/86Sr, and 143Nd/144Nd ratios that originated La Estrella Granite. Our results offer an alternative explanation for the existence of subtle magmatic arc‐like geochemical signatures in the study area and support a segmentation of the active margin during the Late Triassic. The widespread upper‐plate magmatic record of slab‐tearing, spanning the Coastal Cordillera of Central Chile to the intraplate Neuquén basin in Argentina, and the lower mantle record of a slab gap, detected in ours and previous tomotectonic analyses, make the Late Triassic slab‐tearing event in southwestern Pangea the most robustly constrained pre‐Cenozoic slab tear process so far.
Scaling of Floods With Geomorphologic Characteristics and Precipitation Variability Across the Conterminous United States
Authors: Najibi Nasser , Devineni Naresh 
Published: January 2023

AbstractAccurate flood risk assessment requires a comprehensive understanding of flood sensitivity to regional drivers and climate factors. This paper presents the scaling of floods (duration, peak, volume) with geomorphologic characteristics of the basin (i.e., drainage area, slope, elevation) and precipitation patterns (rainfall accumulation, variability). Long‐term daily streamflow observations over the 20th and early 21st centuries from Hydro‐Climatic Data Network streamgages across the conterminous United States are used to create a flood event database based on their flood stage information. Antecedent daily rainfall accumulation and variability corresponding to these floods are computed using Global Historical Climatology Network daily data set. Two Bayesian scaling models are developed, and the spatial organization of scaling exponents is investigated. The baseline model quantifies the scaling of floods to geomorphologic characteristics. The dynamic model quantifies the scaling of floods to antecedent precipitation distribution which is further conditioned on geomorphologic characteristics. Results show that small and low‐elevation basins have a stronger response to antecedent rainfall distribution in amplifying flood peaks, while high‐elevation steeper basins have a lower response for flood duration and volume. The dynamic models demonstrate that there are significant variations in the flood scaling rates, with the largest rates up to 40% and 4.5% for flood duration, 64% and 44% for peak, and 98% and 40% for volume found across the Northeast, Coastal Southeast, and Northwest with intensifying rainfall accumulation and variability, respectively. This study advances flood predictions by better informing the flood attributes in the context of dynamical land‐atmosphere perturbations.
Regorafenib induces Bim-mediated intrinsic apoptosis by blocking AKT-mediated FOXO3a nuclear export
Authors: Sun Beini , Chen Hongce , Wang Xiaoping , Chen Tongsheng 
Published: January 2023

AbstractRegorafenib (REGO) is a synthetic oral multi-kinase inhibitor with potent antitumor activity. In this study, we investigate the molecular mechanisms by which REGO induces apoptosis. REGO induced cytotoxicity, inhibited the proliferation and migration ability of cells, and induced nuclear condensation, and reactive oxygen species (ROS)-dependent apoptosis in cancer cells. REGO downregulated PI3K and p-AKT level, and prevented FOXO3a nuclear export. Most importantly, AKT agonist (SC79) not only inhibited REGO-induced FOXO3a nuclear localization and apoptosis but also restored the proliferation and migration ability of cancer cells, further demonstrating that REGO prevented FOXO3a nuclear export by deactivating PI3K/AKT. REGO treatment promotes Bim expression via the FOXO3a nuclear localization pathway following PI3K/AKT inactivation. REGO induced Bim upregulation and translocation into mitochondria as well as Bim-mediated Bax translocation into mitochondria. Fluorescence resonance energy transfer (FRET) analysis showed that REGO enhanced the binding of Bim to Bak/Bax. Knockdown of Bim, Bak and Bax respectively almost completely inhibited REGO-induced apoptosis, demonstrating the key role of Bim by directly activating Bax/Bak. Knockdown of Bax but not Bak inhibited REGO-induced Drp1 oligomerization in mitochondria. In conclusion, our data demonstrate that REGO promotes apoptosis via the PI3K/AKT/FOXO3a/Bim-mediated intrinsic pathway.
Copper intrauterine device increases vaginal concentrations of inflammatory anaerobes and depletes lactobacilli compared to hormonal options in a randomized trial
Authors: Brown Bryan P. , Feng Colin , Tanko Ramla F. , Jaumdally Shameem Z. , Bunjun Rubina , Dabee Smritee , Happel Anna-Ursula , Gasper Melanie , Nyangahu Donald D. , Onono Maricianah , Nair Gonasagrie , Palanee-Phillips Thesla , Scoville Caitlin W. , Heller Kate , Baeten Jared M. , Bosinger Steven E. , Burgener Adam , Passmore Jo-Ann S. , Heffron Renee , Jaspan Heather B. 
Published: January 2023

AbstractEffective contraceptives are a global health imperative for reproductive-aged women. However, there remains a lack of rigorous data regarding the effects of contraceptive options on vaginal bacteria and inflammation. Among 218 women enrolled into a substudy of the ECHO Trial (NCT02550067), we evaluate the effect of injectable intramuscular depot medroxyprogesterone acetate (DMPA-IM), levonorgestrel implant (LNG), and a copper intrauterine device (Cu-IUD) on the vaginal environment after one and six consecutive months of use, using 16S rRNA gene sequencing and multiplex cytokine assays. Primary endpoints include incident BV occurrence, bacterial diversity, and bacterial and cytokine concentrations. Secondary endpoints are bacterial and cytokine concentrations associated with later HIV seroconversion. Participants randomized to Cu-IUD exhibit elevated bacterial diversity, increased cytokine concentrations, and decreased relative abundance of lactobacilli after one and six months of use, relative to enrollment and other contraceptive options. Total bacterial loads of women using Cu-IUD increase 5.5 fold after six months, predominantly driven by increases in the concentrations of several inflammatory anaerobes. Furthermore, growth ofL. crispatus(MV-1A-US) is inhibited by Cu2+ions below biologically relevant concentrations, in vitro. Our work illustrates deleterious effects on the vaginal environment induced by Cu-IUD initiation, which may adversely impact sexual and reproductive health.
A supramolecular cucurbit[8]uril-based rotaxane chemosensor for the optical tryptophan detection in human serum and urine
Authors: Krämer Joana , Grimm Laura M. , Zhong Chunting , Hirtz Michael , Biedermann Frank 
Published: January 2023

AbstractSensing small biomolecules in biofluids remains challenging for many optical chemosensors based on supramolecular host-guest interactions due to adverse interplays with salts, proteins, and other biofluid components. Instead of following the established strategy of developing alternative synthetic binders with improved affinities and selectivity, we report a molecular engineering approach that addresses this biofluid challenge. Here we introduce a cucurbit[8]uril-based rotaxane chemosensor feasible for sensing the health-relevant biomarker tryptophan at physiologically relevant concentrations, even in protein- and lipid-containing human blood serum and urine. Moreover, this chemosensor enables emission-based high-throughput screening in a microwell plate format and can be used for label-free enzymatic reaction monitoring and chirality sensing. Printed sensor chips with surface-immobilized rotaxane-microarrays are used for fluorescence microscopy imaging of tryptophan. Our system overcomes the limitations of current supramolecular host-guest chemosensors and will foster future applications of supramolecular sensors for molecular diagnostics.
Enhancing CAR-T cell functionality in a patient-specific manner
Authors: Zhang David K. Y. , Adu-Berchie Kwasi , Iyer Siddharth , Liu Yutong , Cieri Nicoletta , Brockman Joshua M. , Neuberg Donna , Wu Catherine J. , Mooney David J. 
Published: January 2023

AbstractPatient responses to autologous CD19 chimeric antigen receptor (CAR) T-cell therapies are limited by insufficient and inconsistent cellular functionality. Here, we show that controlling the precise level of stimulation during T-cell activation to accommodate individual differences in the donor cells will dictate the functional attributes of CAR-T cell products. The functionality of CAR-T cell products, consisting of a diverse set of blood samples derived from healthy donors, acute lymphoblastic leukemia (ALL), and chronic lymphocytic lymphoma (CLL) patient samples, representing a range of patient health status, is tested upon culturing on artificial antigen-presenting cell scaffolds to deliver T-cell stimulatory ligands (anti-CD3/anti-CD28) at highly defined densities. A clear relationship is observed between the dose of stimulation, the phenotype of the T-cell blood sample prior to T-cell activation, and the functionality of the resulting CAR-T cell products. We present a model, based on this dataset, that predicts the precise stimulation needed to manufacture a desired CAR-T cell product, given the input T-cell attributes in the initial blood sample. These findings demonstrate a simple approach to enhance CAR-T functionality by personalizing the level of stimulation during T-cell activation to enable flexible manufacturing of more consistent and potent CAR-T cells.