bluuebunny/crossref_metadata_2025_split huggingface dataset:
Role of cefpodoxime in the treatment of ear infections
Authors: Bansal Chitrak 
Published: March 2023

Background: Acute otitis media (AOM) is a community-acquired respiratory tract infection in childhood frequently encountered by primary-care physicians and can cause a significant morbidity. Increasing bacterial resistance has led to concern about the current options for empirical antibiotic treatment and has prompted a search for effective treatments. Objectives: To evaluate the clinical efficacy and safety of cefpodoxime proxetil in the treatment of children with acute otitis media. Patients and methods: A prospective, multicenter study was conducted on 1380 children aged from 1 to 13 years with AOM who were prescribed a 5–10 day course of cefpodoxime proxetil (8 mg/kg/day). Patients were followed-up after 7–14 days from baseline visit. Efficacy was assessed by the percentage of patients with clinical cure, improvement or failure at the follow-up visit. Safety was evaluated by recording the occurrence and severity of any adverse events and by the physicians’ and patients’ assessment of overall tolerability. Results: Clinically, 82.5% of patients were cured, 16.4% were improved and there was failure of therapy in 1.1% of the patients. The overall combined cure and improvement rate of all related signs and symptoms was 98.9%. Adverse events, diarrhea and skin rash, were reported by only 16 patients (1.2%).
ALGORITMO PARTICIPATIVO E FABRICAÇÃO DIGITAL: FERRAMENTA DIGITAL PARA ADEQUAÇÃO ARQUITETÔNICA
Authors: Backheuser Luiz Alberto Fresl , de Campos Paulo Eduardo Fonseca 
Published: March 2023

RESUMOSe o movimento moderno defendeu uma produção impositiva, onde o arquiteto poderia definir de maneira autoritária o desenho das cidades e seus edifícios, a partir de meados do século XX suas práticas e teorias passam a ser duramente criticadas. Alternativas contextualizadoras e participativas foram valorizadas como respostas a um mundo cada vez mais complexo, plural e diversificado. A inadequação arquitetônica às comunidades e famílias dos grandes conjuntos residenciais modernista aparece com frequência em debates profissionais, acadêmicos e nas comunidades em questão. Assim, o processo passa a ser debatido, em detrimento do produto. Se temos que considerar mais variáveis, a maneira como se atinge o resultado ganha importância sobre o resultado em si, que passa a ser inesperado. Na mesma época, autores como William Mitchel, Nicholas Negroponte, Yona Friedman e Christopher Alexander, defendem a união de processos participativos e ferramentas computacionais. União essa que vem sendo debatida até hoje com autores como José Pinto Duarte e Branko Kolarevic, que trazem o conceito de customização em massa para a arquitetura e o urbanismo. Assim, o presente trabalho pretende refletir sobre processos participativos viabilizados por ferramentas digitais, a partir de um experimento, um algoritmo associado a um sistema construtivo, que permite a personalização de uma arquitetura. O experimento se apropriará de outra pesquisa que desde de 2015 vem procurando adaptar diferentes experiências internacionais de soluções construtivas baseadas em um método subtrativo de fabricação digital. Espera-se, assim, contribuir com as discussões tanto sobre a participação dos usuários quando sobre a apropriação de novas tecnologias.
ENTRE DESCARTÁVEIS E REUTILIZÁVEIS: POLÍTICAS PÚBLICAS SOBRE POBREZA MENSTRUAL NO NORDESTE DO BRASIL E OBSERVAÇÃO DE TECNOLOGIAS SOCIAIS INTEGRADAS
Authors: De Melo Evelynne Hildegard Marques , Pinto Caroline de Menezes , Mendonça Adriana de Lima , Barboza Railson da Silva 
Published: March 2023

Probreza menstrual é o termo dado ao contexto que envolve vários aspectos sociais ligados a higiene da pessoa que menstrua. Tabus e ausência de olhar político exacerbam o problema. Trata-se de uma questão social mundial inteiramente ligada a fisiologia e dependente de política para minimizar consequências em saúde pública envolvendo uma tecnologia que é o absorvente para fluxo menstrual como algo imprescindível. Para resoluções neste tema, no Brasil, as unidades federativas encontram-se ao nível de propostas legislativas e o Rio de Janeiro representa pioneirismo. Este trabalho tem o objetivo de destacar a importância das políticas públicas de estado sustentáveis, através da análise das proposições políticas entre os meios descartáveis e reutilizáveis na região nordeste do Brasil e apresentar tecnologia sociais que auxiliem nas soluções. Em todas as capitais da região nordeste há iniciativas legislativas para o combate à pobreza menstrual, contudo os esforços direcionados ao método reutilizável deve ser desencorajado pelas razões óbvias da dependência de infraestrutura básica essencial à higiene, para as quais o nordeste mantém críticos índices.
ANALISIS PERPUTARAN MODAL KERJA DAN RENTABILITAS PADA KOPERASI SIMPAN PINJAM MANDIRI BINA LESTARI PINANGSORI KABUPATEN TAPANULI TENGAH
Authors: PEBRIANI KRISTINARTI HALAWA  , FAUZIAH NUR SIMAMORA  , Safriadi Pohan  
Published: March 2023

ABSTRACT

This study aims to describe the turnover of working capital of the Bina Lestari Pinangsori Mandiri Savings and Loans Cooperative in Central Tapanuli Regency and to explain the level of profitability of the Bina Lestari Pinangsori Mandiri Savings and Loans Cooperative in Central Tapanuli Regency. The research method used is descriptive method with analysis of working capital turnover ratios (cash turnover ratios, accounts receivable turnover, inventory turnover), and profitability ratios (total asset turnover). The results of the analysis show that the working capital turnover of the Mandiri Bina Lestari Pinangsori Savings and Loans Cooperative, Central Tapanuli Regency for 2019-2021 based on the cash turnover ratio and inventory turnover ratio is considered good or effective, and based on the accounts receivable turnover ratio it is very slow so it is considered ineffective. Meanwhile, based on the ratio of asset profitability achieved, it shows that the Bina Lestari Pinangsori Mandiri Savings and Loans Cooperative in Central Tapanuli Regency is not yet profitable.

Keywords: Working capital, Profitability
Analysis of The Effectiveness of Integrated Information System Implementation (Case Study: PT Samudera Mulia Abadi Tbk)
Authors: Wangkar Anneke 
Published: March 2023

Entering the era of information and free trade, PT. Samudera Mulia Abadi requires a certain advantage in order to face national and international competition. For this reason, every company strives to provide the best service facilities for customers through the accuracy, precision and effectiveness of information. These things must be supported by the development of information technology at this time. An organization that has a well-designed information system will generally have a competitive advantage over an organization with a weaker system. However, the facts show that the implementation of an information system is not easy. The more departments related to the information system, the more complex the information system will be and the higher the risk of failure. This research takes a case study of the effectiveness of information system implementation at PT Samudera Mulia Abadi (SMA) and what factors influence it. The method use in this study is a survey method by distributing questionnaires to all respondents who use an integrated information system at PT SMA. From the research results, it was found that several factors influence the effectiveness of information system implementation, including : user interaction with information systems, IT support, involvement of consultants and features of information systems. Without the above factors, it is very unlikely that companies that implement integrated information systems can take maximum advantage of integrated information systems that are applied to their companies
The Prevalence of Myopia among School Students in Urban Area Bangladesh and to Explore the Associations between Reading and Writing Postures and Myopia
Authors: Faridi Jamsed , Ferdausi Nahid , Hossain Mohammed Monir , Paul Subrata Kumar , Islam Md. Adnan , Bhuyan Md. Mahboobur Rahman 
Published: March 2023

Background: Myopia, often known as near-sightedness, is a common visual issue that typically first appears between the ages of 6 and 14. Roughly 5% of toddlers, 9% of elementary schoolchildren, and 30% of high schoolers are affected. Having near-sighted parents increases a child's risk of developing myopia.
Objective: To assess the prevalence of myopia among school students in urban area Bangladesh and to explore the associations between reading and writing postures and myopia.
Methodology: A complicated, stratified, multistage sample design was used to select the participants from January 2019 to January 2020. Using a random number generator, we chose one urban region and one rural area in Bangladesh, and at least 50 students from each grade in elementary, middle, and high school participated in the studies. Students from elementary school (n=50), middle school (n=50), and high school (n=50) were all included in our study, which included a total of 150 participants.
Results: During the study, mean age of the patients was 10.50± 0.86 years. Followed by middle school group mean age was 14.09 ± 0.92 years and high school group was 16.55 ± 0.89. Plus majority were male. In primary school group 35% cases usually had their chest is more than the width of a fist from the edge of the table. Followed by in middle school group it was 25% and in high school group it was 27%. Plus, in primary school group 26% had usually eyes are more than 33 cm (one Chi) away from the book followed by in middle school group it was 30% and 31%. Regarding the associations between reading and writing postures and myopia, we identified that a reading distance >33 cm is a protective factor for myopia in female students [odds ratio (OR) = 0.31, 95% confidence interval (CI) = 0.15–0.64], in both primary school (OR = 0.55, 95% CI = 0.30–0.99) and middle school (OR = 0.37, 95% CI = 0.15–0.90)
Conclusion: A reading distance >33 cm can be used as an additional measure to prevent and control myopia. Proper postural measures for reading and writing may have educational and public health benefits.
Medical Oxygen Mandate and Blazes Inhibition in Emerging Hospital ICUs, India
Authors: Mishra Siba Prasad , Mishra Saswat 
Published: March 2023

Aims and Objective: Pure Oxygen proved palliative care or considered a lifesaving drug causing innumerable deaths due to its inaccessibility against SARS-COVID-19. Medical oxygen (MOX) availability in COVID Care Hospitals (CCHs) in India was scanty during the peak period of the pandemic. The fatalities, trauma, and fire incidences in CCHs had increased multifold.
Methodology: The major fires in hospitals from March 2020 were collected from media and past literature and analyzed considering causalities, time, sectors, pre-pandemic, etc. The world faced MOX shortages and infrastructural lags with wildfire hazards in CCHs have forced the research. The fire incidents in major hospitals, globally, and 150 hospitals in India are analyzed from the 20th century onwards.
Focused Area: The SARS-2 virus has been undergoing many mutations and remediation to date. MOX supply chain was observed distorted from the manufacturer, to end users during its 2nd phase. The existing architecture of COVID beds, space, MOX demand, resource management, and heating Ventilating & air conditioning (HVAC) bottlenecks needs rebuilding.
Results and Future Research: The blazes in the early 20th century were mainly due to curtains, kitchens, chimneys, etc. whereas electrical short circuits cause the 21st-century hospital blazes from HVAC systems and surges in oxygen levels in ICUs. The higher oxygen level and poor maintenance of electrical gadgets are the attributes. The blazing timing causes were from 6 PM to 8 AM, mostly in Government hospitals. This study can prioritize and stimulate curative measures in hospital fire safety and epidemiology of MOX generation, storing, transportation, and carriage in case of future biological disasters.
Nutritional, Phytochemicals, GC-MS and Antibacterial Activities of Aqueous Red Onion (Allium cepa) Extract against Staphylococcus aureus and Escherichia coli
Authors: Momoh Johnson Oshiobugie , Manuwa Adefunmilayo Alaba , Ayinde Folashade Adunni , Bankole Yakub Olawale 
Published: March 2023

Background of Study: Onion (Allium cepa) plant has been used for multiple purposes both for modern and traditional medicine. The study evaluates the atomic absorption spectroscopy (AAS), Gas chromatography–mass spectrometry (GC-MS) and antibacterial activities of aqueous red onion (Allium cepa) and azithromycin solution against Staphylococcus aureus and Escherichia coli.
Methodology: The AAS, GC-MS and phytochemical screening of the aqueous red onion (Allium cepa) extract were determined using standard procedures. Antibacterial activities were determined by agar well diffusion method. The minimum inhibitory concentrations (MIC) and minimum bactericidal concentrations were determined using standard procedure.
Results: Mineral analysis shows that the minerals that were found in the red onion are: Na, Mg, Fe, Ca, K, Al and Cu. Aqueous extract of Allium cepa shows the presence of secondary metabolites like: saponin, tannins, alkaloids, flavonoids, phenolic compounds, reducing sugar, steroids etc. 56 compounds were identified using GC-MS analysis with 9, 12-octadecadienoic acid (Z,Z)- being the most abundant with peak area of 50.50% and retention time of 16.563. The results revealed that aqueous A. cepa extract with concentration of 250 mg/ml showed strong response against Staphylococcus aureus and Escherichia coli with zone of inhibition of 22.67±1.585 and 28.18±1.689 respectively. At 100 mg/ml, the onion extract exhibited weak and moderate response against both organisms. The azithromycin solution has zone of inhibition values that ranges from 9.25 ± 0.73 to 20.03 ± 1.16 mm for both organisms tested at 5.00 and 20.00 mg/mL respectively. The MIC values of the azithromycin solution and aqueous red onion extract for S. aureus and E. coli were 31.25, 31.25, 500 and 250 mg/mL while their MBC values were 62.50, 62.50, 1000.00 and 500.00 mg/ml respectively. MBC/MIC values indicate that azithromycin solution and aqueous red onion extract had bactericidal effects on both organisms tested. The red onion has potential as natural therapeutic agents and may prevent pathogenic diseases caused by Staphylococcus aureus and Escherichia coli.
Spectrophotometric Analysis of Variation of Fluoride Content in Dentifrices – A Quantitative Study
Authors: Mudaliar Akshaya , Baviskar Mansi , Kodical Sanjana R. , Chaudhary Chinmaya , Mehta Aayushi 
Published: March 2023

Background: A dentifrice and a toothbrush are universal armamentariums for oral hygiene maintenance. The presence of fluoride in commercial dentifrices aids in dental caries prevention. The fluoride content and compound are mentioned on the packaging along with the time of manufacture and its shelf life.
Aim: To evaluate the fluoride concentration of dentifrices available commercially over a period of time from the date of manufacture.
To compare any variations in the fluoride concentration over time to the content present at manufacture.
Methodology: This is an In vitro comparative observational study. 8 Standard dentifrices easily available Over the Counter were selected, of which 3 were for adult use, 2 were herbal and 3 were for kids. They were subjected to fluoride analysis and the fluoride content was assessed using spectrophotometric analysis, by a single blinded examiner. The test sample was compared to a standard solution, in a calibration curve to determine the fluoride concentration.
Results: On analysis it was seen that adult toothpaste samples had fluoride concentration lower than 1000ppm as mentioned on the label. One herbal toothpaste had fluoride concentration of 1039.62ppm which was higher than that mentioned on the label. One kids toothpaste had fluoride concentration of 905.25ppm which was higher than that mentioned on the label.
Conclusion: The toothpastes included in the study had dissimilar fluoride concentrations after analysis than the concentration mentioned on the label. Thus, waranting better laws and standardization methods for toothpastes.
Long noncoding RNAs with peptide‐encoding potential identified in esophageal squamous cell carcinoma: KDM4A‐AS1‐encoded peptide weakens cancer cell viability and migratory capacity
Authors: Zhou Bo , Wu Yuyang , Cheng Pei , Wu Chengyong 
Published: March 2023

Currently, the knowledge of long noncoding RNA (lncRNA)‐encoded peptides is quite lacking in esophageal squamous cell carcinoma (ESCC). In this study, we simultaneously identified six lncRNA open reading frames (ORFs) with peptide‐coding abilities including lysine‐specific demethylase 4A antisense RNA 1 (KDM4A‐AS1) ORF by combining weighted gene co‐expression network analysis (WGCNA) for ESCC clinical samples, ribosome footprints, ORF prediction, mass spectrometry (MS) identification, and western blotting. KDM4A‐AS1 ORF‐encoded peptide reduced ESCC cell viability and migratory ability. Co‐immunoprecipitation and MS analysis revealed that KDM4A‐AS1‐encoded peptide specifically bound with 103 proteins in ESCC cells, and enrichment analysis suggested that peptide‐bound proteins were related to fatty acid metabolism and redox process. Cell and molecular experiments demonstrated that KDM4A‐AS1‐encoded peptide inhibited stearoyl‐CoA desaturase and fatty acid synthase expression, increased reactive oxygen species level, and reduced mitochondrial membrane potential in ESCC cells. In summary, multiple lncRNAs with translation potential were simultaneously identified by combining multiple approaches in ESCC, providing novel identification strategies for lncRNA‐encoded peptides. Moreover, lncRNA KDM4A‐AS1‐encoded peptide weakened ESCC cell viability and migratory capacity and functioned in fatty acid metabolism and redox process.
911 calls in mysterious disappearances of children: Indicators of veracity and deception
Authors: O'Donnell Daniel E. , Shelton Joy Lynn , Huffman Michelle C. , Porter Kathryn , Miller Michelle 
Published: March 2023

Abstract911 calls reporting the mysterious disappearance of a child may contain information critical to law enforcement. If this information is untruthful, valuable resources can be misdirected and precious time may be lost. Therefore, the current study examined verbal cues of veracity and deception in 911 calls placed by caregivers of missing children. Specifically, the current study compared differences between a sample of caregivers who falsely reported a child missing to conceal their role in the child's homicide and truthful caregivers who reported a child missing and had no knowledge of the child's whereabouts at the time of the call. Results show promise and consistency with previously proposed indicators of veracity and deception. Specifically, a greater number of self‐handicapping statements were made by deceptive individuals, whereas truthtellers were more likely to spontaneously self‐correct. Practical implications are discussed.
Impact of Loneliness and Social Isolation on Mental Health Outcomes Among Individuals With Rheumatic Diseases During the COVID‐19 Pandemic
Authors: Howren Alyssa , Avina‐Zubieta J. Antonio , Puyat Joseph H. , Da Costa Deborah , Xie Hui , Davidson Eileen , Rebić Nevena , Gastonguay Louise , Dau Hallie , De Vera Mary A. 
Published: March 2023

ObjectiveThe study objective was to assess mental and social health outcomes for individuals with rheumatic disease during the COVID‐19 pandemic and evaluate the relationship of loneliness and social isolation with depression and anxiety.MethodsWe administered an international cross‐sectional online survey to individuals with rheumatic disease(s) (≥18 years) between April 2020 and September 2020, with a follow‐up survey from December 2020 to February 2021. We used questionnaires to evaluate loneliness (3‐item UCLA Loneliness Scale [UCLA‐3]), social isolation (Lubben Social Network Scale [LSNS‐6]), depression (Patient Health Questionnaire [PHQ‐9]), and anxiety (Generalized Anxiety Disorder 7‐item [GAD‐7] Scale). We used multivariable linear regression models to evaluate the cross‐sectional associations of loneliness and social isolation with depression and anxiety at baseline.ResultsSeven hundred eighteen individuals (91.4% women, mean age: 45.4 ± 14.2 years) participated in the baseline survey, and 344 completed the follow‐up survey. Overall, 51.1% of participants experienced loneliness (UCLA‐3 score ≥6) and 30.3% experienced social isolation (LSNS‐6 score <12) at baseline. Depression (PHQ‐9 score ≥10) and anxiety (GAD‐7 score ≥10) were experienced by 42.8% and 34.0% of participants at baseline, respectively. Multivariable models showed that experiencing both loneliness and social isolation, in comparison to experiencing neither, was significantly associated with an average 7.27 higher depression score (ß = 7.27; 95% confidence interval [CI]: 6.08‐8.47) and 5.14 higher anxiety score (ß = 5.14; 95% CI: 4.00‐6.28).ConclusionAside from showing substantial experience of loneliness and social isolation during the COVID‐19 pandemic, our survey showed significant associations with depression and anxiety. Patient supports to address social health have potential implications for also supporting mental health.
Reaction‐Induced Formation of Stable Mononuclear Cu(I)Cl Species on Carbon for Low‐Footprint Vinyl Chloride Production
Authors: Faust Akl Dario , Giannakakis Georgios , Ruiz‐Ferrando Andrea , Agrachev Mikhail , Medrano‐García Juan D. , Guillén‐Gosálbez Gonzalo , Jeschke Gunnar , Clark Adam H. , Safonova Olga V. , Mitchell Sharon , López Núria , Pérez‐Ramírez Javier 
Published: March 2023

AbstractCopper catalysts are attractive candidates for Hg‐free vinyl chloride monomer (VCM) production via acetylene hydrochlorination due to their non‐toxic nature and high stability. However, the optimal architecture for Cu‐based catalysts at the nanoscale is not yet fully understood. To address this gap, the metal precursor and the annealing temperature are modified to prepare copper nanoparticles or single atoms, either in chlorinated or ligand‐free form, on an unmodified carbon support. Evaluation in the reaction reveals a remarkable convergence of the performance of all materials to the stable VCM productivity of the single‐atom catalyst. In‐depth characterization by advanced microscopy, quasi in situ and operando spectroscopy, and simulations uncover a reaction‐induced formation of low‐valent, single atom Cu(I)Cl site motif, regardless of the initial nanostructure. Various surface oxygen groups promote nanoparticle redispersion by stabilizing single‐atom CuClx species. The anchoring site structure does not strongly influence the acetylene adsorption energy or the crucial role they play in stabilizing key reaction intermediates. A life‐cycle assessment demonstrates the potential environmental benefits of copper catalysts over state‐of‐the‐art alternatives. This work contributes to a better understanding of optimal metal speciation and highlights the sustainability of Cu‐based catalysts for VCM production.