bluuebunny/crossref_metadata_2025_split huggingface dataset:
Low-CO2inducible bestrophins in diatom thylakoid membranes sustain high photosynthetic efficacy at distant locations from the pyrenoid
Authors: Nigishi Minori , Shimakawa Ginga , Yamagishi Kansei , Amano Ryosuke , Ito Shun , Tsuji Yoshinori , Nagasato Chikako , Matsuda Yusuke 
Published: September 2023

AbstractAnion transporters are important to sustain a variety of physiological states in cells. Bestrophins are a family of Cl−and/or HCO3−transporters conserved in bacteria, animals, algae, and plants. Recently, bestrophin paralogs were found in the green algaChlamydomonas reinhardtiias up- regulated components in low CO2conditions that play an essential role in the CO2- concentrating mechanism (CCM). Bestrophin orthologs are also conserved in diatoms, a group of secondary endosymbiotic algae harboring red-type plastids, but their physiological functions are not known yet. Here, we characterized the subcellular localization and expression profile of bestrophins in the marine diatomsPhaeodactylum tricornutum(PtBST1−4) andThalassiosira pseudonana(TpBST1 and 2). PtBST1 and PtBST2 were localized at the stromal thylakoid membrane outside of the pyrenoid, and PtBST3 was localized in the pyrenoid. Contrarily, TpBST1 and TpBST2 were both localized in the pyrenoid. These bestrophin proteins were accumulated in cells grown in atmospheric CO2but not in 1% CO2-grown cells. To assess the physiological functions, we generated knock-out mutants for PtBST1 by genome editing. The lack of PtBST1 decreased affinity of photosynthesis for dissolved inorganic carbon closer to that of the cells grown in 1% CO2. Additionally, non-photochemical quenching was 1.5–2.0 times higher in the mutants than that of the wild type cells. These data suggests that HCO3−transport at the stroma thylakoid membranes by PtBST1 is a critical part of the CO2evolving system of the pyrenoid in the fully induced CCM, and simultaneously that PtBST1 modulates photoprotection in response to CO2availability inP. tricornutum.Significant statementMarine diatoms are responsible for nearly half of oceanic primary production, owing to the high-affinity photosynthesis for dissolved inorganic carbon which is supported by CO2- concentrating mechanism (CCM). This study uncovered that a bestrophin family protein at the stoma thylakoid membrane operates to import HCO3−to the thylakoid lumen and mobilizes it towards the CO2evolving system at the pyrenoid-penetrating thylakoid in the diatomPhaeodactylum tricornutum. This HCO3−collecting system not only enhances the CCM but also down regulates the photoprotection capacity of photosystem II, presumably by affecting the thylakoid lumen acidification. This study experimentally demonstrates the molecular mechanism how diatoms optimize the use of CO2and light energy, giving an insight into the reason of ecological successfulness of marine diatoms.
Progress of research on gallic acid in corrosion inhibition and rust removal protection of metals
Authors: Li Jiaxin , Zhu Zhiyuan , Li Zhiwei , Zhao Yonggang , Lei Yun , Su Xuping , Wu Changjun , Peng Haoping 
Published: September 2023

PurposeGallic acid is a substance that is widely found in nature. Initially, it was only used as a corrosion inhibitor to retard the rate of corrosion of metals. In recent years, with intensive research by scholars, the modification of coatings containing gallic acid has become a hot topic in the field of metal protection. This study aims to summarize the various preparation methods of gallic acid and its research progress in corrosion inhibitors and coatings, as well as related studies using quantum chemical methods to assess the predicted corrosion inhibition effects and to systematically describe the prospects and current status of gallic acid applications in the field of metal corrosion inhibition and protection.Design/methodology/approachFirst, the various methods of preparation of gallic acid in industry are understood. Second, the corrosion inhibition principles and research progress of gallic acid as a metal corrosion inhibitor are presented. Then, the corrosion inhibition principles and research progress of gallic acid involved in the synthesis and modification of various rust conversion coatings, nano-coatings and organic resin coatings are described. After that, studies related to the evaluation and prediction of gallic acid corrosion inhibition on metals by quantum chemical methods are presented. Finally, new research ideas on gallic acid in the field of corrosion inhibition and protection of metals are summarized.FindingsGallic acid can be used as a corrosion inhibitor or coating in metal protection.Research limitations/implicationsThere is a lack of research on the synergistic improvement of gallic acid and other substances.Practical implicationsThe specific application of gallic acid in the field of metal protection was summarized, and the future research focus was put forward.Originality/valueTo the best of the authors’ knowledge, this paper systematically expounds on the research progress of gallic acid in the field of metal protection for the first time and provides new ideas and directions for future research.
Sisterhood in academia: building a flock culture to cope and thrive
Authors: Hardie Geraldine , Almeida Shamika , Wijayawardena Kanchana , Frino Betty , Wang Hui-Ling , Rauf Afshan 
Published: September 2023

PurposeThis paper examines the experiences of a team of female academics (teaching a large cohort of undergraduate students) and the coping mechanisms used to combat the challenges they confront in the Australian higher education sector.Design/methodology/approachUsing a reflective autoethnographic method and strengths perspective, the authors share experiences as female professionals whose intersectional identities presented challenges that extend beyond those typically found in the current higher education setting.FindingsThe individualized nature of academic work exacerbates the systemic marginalization of female academics. Adopting a flock culture serves as a support network for addressing the various intersectional challenges. The authors liken the “flock cultural approach” to a “sisterhood” where individuals impacted by intersectional challenges build a strong and cohesive unit to support each other by utilizing their combined strengths to create positive synergy to cope with ongoing workplace challenges.Research limitations/implicationsThe study highlights the benefit of the strengths perspective to understand how female academics with intersectional identities can overcome the challenges of their highly individualized profession.Practical implicationsThis paper highlights the importance of building team-based work, cultivating collective achievement and high trust in a highly individualistic profession.Social implicationsUsing the strength perspective, the authors disrupt the conventional and currently narrow usage of sisterhood to help develop strong, adaptive, flexible and responsive bonds among diverse female academics. The findings point to how using a “flock culture” – a membership-based philosophy – became the key support mechanism for the marginalized groups, empowering them to confront the systemic barriers within their profession.Originality/valueFirst, the findings of this study are shaped by the intersections of factors such as ethnicity, age, race, religion and mode of employment, which all influences the participants’ lived experiences. Second, this study contributes to the transnational feminist movement by unveiling the contextualized barriers that junior academic females from various migrant backgrounds face and identify how they synergized their collective strengths to survive the challenging academic environment. Third, using the strength perspective, the authors disrupt the conventional and currently narrow usage of sisterhood to help develop strong, adaptive, flexible and responsive bonds among diverse female academics.
Financial development and growth nexus in Asian countries: mediating role of FDI, foreign aid and trade
Authors: Patra Biswajit , Sethi Narayan 
Published: September 2023

PurposeThis paper analyzes the direct effect of financial development and the mediating impact of financial development through foreign direct investment (FDI), foreign aid and trade on economic growth for all Asian countries.Design/methodology/approachA fixed-effect model with Driscoll–Kraay panel corrected estimators was employed to find the direct and mediating impact of financial developments on growth for all 47 Asian economies from 1980 to 2020. The bootstrapped panel-quantile regression (BPQR) model is used to check how this effect varies for different income groups of countries.FindingsThe results demonstrated that financial development positively impacts countries' economic growth. The interaction effect of financial development with FDI, foreign aid and foreign trade negatively impacts economic growth. The BPQR results showed that FDI and foreign aid help in the growth of lower quantile economies; however, the impact is negative for middle- and upper-income countries. Trade impacts growth positively for all the quantiles of economies.Research limitations/implicationsThe results suggest that the Asian economies must continue to provide thrust on the financial development of their own countries to achieve better growth. It also implied that the dependence on external finance is good for low-income countries and not advisable for middle- and upper-income countries.Originality/valueTo the best of the authors’ knowledge, the current study is the first to provide empirical evidence on analyzing both the direct and interaction effect of financial development on economic growth by considering all the Asian economies.Peer reviewThe peer review history for this article is available at: https://publons.com/publon/10.1108/IJSE-09-2022-0587
Feeling stressed but in full flow? Leader mindfulness shapes subordinates' perseverative cognition and reaction
Authors: Xie Haoju , Feng Xingyu 
Published: September 2023

PurposeThis study aims to illustrate the mechanisms underlying the effect of stress on flow states in the context of a multilevel organization, in which case employees' perseverative cognition and reactions to challenge–hindrance stressors are affected by leader mindfulness.Design/methodology/approachStudy 1 employed a three-wave time-lag survey, and study 2 conducted a diary study across 10 workdays to replicate the results of study 1. Multilevel structural equation modeling and Monte Carlo simulation were performed using Mplus 8.0 software to test all hypotheses.FindingsProblem-solving pondering transmits the nonlinear effect of challenge stressors on flow, and affective rumination mediates the negative effect of hindrance stressors on flow. Leader mindfulness amplifies the tendency of followers to ruminate on the positive aspects of challenge stressors, consequently increasing their positive reactions and flow. Although leader mindfulness fails to influence followers to ruminate less on hindrance stressors, it negates the harmful effect of affective rumination on the flow experience.Originality/valueThis study is one of the first to examine the associations between stressor types and flow in the workplace. The authors also develop a new theory that highlights the ability of leader mindfulness to shape subordinates' stress, cognitions and reactions through social modeling and the authors identify the boundaries of its beneficial effects.
Outcomes of hemorrhagic stroke in patients with autoimmune rheumatic diseases: An analysis of the US Nationwide Inpatient Sample
Authors: Chen Mao‐Yu , Chen Pin‐Yuan , Chang Chen‐Nen , Chen Bo‐An , Deng Wen‐Chun , Yan Jiun‐Lin 
Published: September 2023

AbstractAimTo determine whether and how rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and systemic sclerosis (SSc) affect outcomes in patients admitted for hemorrhagic stroke.MethodsThis study screened the Nationwide Inpatient Sample database for adults aged ≥20 years admitted to US hospitals with a principal diagnosis of intracerebral hemorrhage (ICH) between 2005 and 2018. Diagnoses were determined using the International Classification of Diseases, 9th and 10th revisions (ICD‐9 and ICD‐10) diagnostic codes for ICH (ICD‐9: 431, 432; ICD‐10: I61, I62). Study outcomes were: (1) in‐hospital mortality; (2) unfavorable discharge, defined as transfer to nursing homes or long‐term care facilities; and (3) prolonged length of stay (LOS), defined as LOS >75th centile.ResultsAssociations between comorbid RA, SLE, and SSc and clinical outcomes show a significantly lower risk of in‐hospital mortality and prolonged LOS in RA patients. After admissions for ICH, the risk for in‐hospital mortality and prolonged LOS was decreased in RA patients, and the risk for unfavorable discharge (long‐term care) was reduced in SLE patients.ConclusionsAmong patients admitted to US hospitals for hemorrhagic stroke, patients with RA had decreased risk for in‐hospital mortality and prolonged LOS.
Equalising the evidence base for adaptation and loss and damages
Authors: Otto Friederike E. L. , Fabian Frederick 
Published: September 2023

AbstractSince the UNFCCC Paris Agreement came into force after 2015 international climate policy rests on three pillars: mitigation, adaptation and loss and damage. However, while there are clear agreed‐upon metrics to measure emissions, base mitigation goals against and hold countries and companies accountable to, the evidence base for the impacts of climate change to inform adaptation and loss and damage is very different. There are no agreed‐upon metrics, nor are there guidelines or criteria to delineate the impacts of climate change from other drivers of losses and damages. This imbalance is reflected in the lack of ability to set and enforce goals. With a new body of scientific evidence introduced in the IPCC, we argue that this can change. Especially with an increasing number of climate litigation cases being recognised as a legitimate root to justice, and thus being given due consideration in courts, the imbalance in evidence could change and put adaptation and loss and damage on more equal footing with mitigation.
Extracellular shuttling miR‐21 contributes to esophageal cancers and human umbilical vein endothelial cell communication in the tumor microenvironment and promotes tumor angiogenesis by targeting phosphatase and tensinhomolog
Authors: Zheng Shanbo , Liao Juan , Sun Mingjun , Liu Ran , Lv Junjie 
Published: September 2023

AbstractBackgroundCell‐cell communication by carcinoma‐derived exosomes can influence the tumor microenvironment (TME) and regulate cancer progression. Based on the overexpression of microRNA‐21‐5p (miR‐21) in plasma from patients diagnosed with esophageal squamous cell carcinoma (ESCC) and exosomes from ESCC cell lines identified earlier, this study aimed to explore the influence of exosomal miR‐21 within the TME.MethodScRNA‐Seq and Bulk RNA‐Seq were integrated to elucidate the communication between cancer and endothelial cells. The functionality and mechanisms by which exo‐miR‐21 derived from carcinoma regulate endothelial cell‐mediated angiogenesis were assessed using a cocultivation model of EC9706 cells and recipient human umbilical vein endothelial cells (HUVECs), through blood vessel formation experiments, luciferase reporter assays, RT‐qPCR, and western blot analysis.ResultA total of 3842 endothelial cells were extracted from the scRNA‐seq data of ESCC samples and reclustered into five cell subtype. Cell‐cell communication analysis revealed cancer cells presented a strong interaction with angiogenesis‐like endothelial cells in secreted signaling. MiR‐21 was unregulated in ESCC and the carcinoma‐derived exo‐miR‐21 was significantly raised in HUVECs. The exo‐miR‐21 promoted the proliferation and migration of HUVECs while also enhancing, closed mesh count, and junction number in HUVECs. Mechanistically, dual‐luciferase reporter assay revealed that PTEN was the target of miR‐21. Meanwhile, p‐Akt was significantly increased and suppressed by inhibition of miR‐21 and PI3K inhibitor LY294002.ConclusionExo‐miR‐21‐mediated communication between endothelial and cancer cells plays a pivotal role in promoting the angiogenesis of ESCC. Therefore, controlling exo‐miR‐21 could serve as a novel therapeutic strategy for ESCC by targeting angiogenesis.
The merits of securities litigation and corporate reputation
Authors: Donelson Dain C. , Kartapanis Antonis , Yust Christopher G. 
Published: September 2023

AbstractWe explore how securities litigation affects corporate reputation. Experts remain concerned that nonmeritorious securities class actions—those that will be dismissed or settled for nuisance amounts—cause reputational damage. Although several prior studies show reputational costs for nonmeritorious cases, they generally use indirect measures based on returns or total market losses, which are mechanically associated with securities litigation elements. In contrast, we use a relatively direct reputation measure from Fortune's “Most Admired Companies” list. We find significant reputational damage after meritorious litigation, with the strongest cases having the largest effects. However, we find no evidence of reputational damage after nonmeritorious litigation. We also find that Fortune's reputational damage measure is associated with more negative returns around the litigation filing date. We show possible mechanisms for our results, as initial legal filings contain information allowing market participants to assess case merits. Our results imply that reputational damage is primarily due to fraud, which securities litigation helps reveal to the market, rather than litigation itself. Thus, reputational damage is not an issue in over 70% of securities class actions due to the high frequency of nonmeritorious cases.
A comparison of the effect of patient‐specific versus weight‐based protocols to treat vaso‐occlusive episodes in the emergency department
Authors: Tanabe Paula , Ibemere Stephanie , Pierce Ava E. , Freiermuth Caroline E. , Bosworth Hayden B. , Yang Hongqui , Osunkwo Ifeyinwa , Paxton James H. , Strouse John J. , Miller Joseph , Paice Judith A. , Veeramreddy Padmaja , Kavanagh Patricia L. , Wilkerson R. Gentry , Hughes Robert , Barnhart Huiman X. 
Published: September 2023

AbstractBackgroundVaso‐occlusive crises (VOCs) cause debilitating pain and are a common cause of emergency department (ED) visits, for people with sickle cell disease (SCD). Strategies for achieving optimal pain control vary widely despite evidence‐based guidelines. We tested existing guidelines and hypothesized that a patient‐specific pain protocol (PSP) written by their SCD provider may be more effective than weight‐based (WB) dosing of parenteral opiate medication, in relieving pain.MethodsThis study was a prospective, randomized controlled trial comparing a PSP versus WB protocol for patients presenting with VOCs to six EDs. Patients were randomized to a PSP or WB protocol prior to an ED visit. The SCD provider wrote their protocol and placed it in the electronic health record for future ED visits with VOC exclusion criteria that included preexisting PSP excluding parenteral opioid analgesia or outpatient use of buprenorphine or methadone or highly suspected for COVID‐19. Pain intensity scores, side effects, and safety were obtained every 30 min for up to 6 h post–ED bed placement. The primary outcome was change in pain intensity score from placement in an ED space to disposition or 6 h.ResultsA total of 328 subjects were randomized; 104 participants enrolled (ED visit, target n = 230) with complete data for 96 visits. The study was unable to reach the target sample size and stopped early due to the impact of COVID‐19. We found no significant differences between groups in the primary outcome; patients randomized to a PSP had a shorter ED length of stay (p = 0.008), and the prevalence of side effects was low in both groups. Subjects in both groups experienced both a clinically meaningful and a statistically significant decrease in pain (27 mm on a 0‐ to 100‐mm scale).ConclusionsWe found a shorter ED length of stay for patients assigned to a PSP. Patients in both groups experienced good pain relief without significant side effects.
Practice and development of male contraception: European Academy of Andrology and American Society of Andrology guidelines
Authors: Wang Christina , Meriggiola Maria Cristina , Amory John K. , Barratt Christopher L. R. , Behre Hermann M. , Bremner William J. , Ferlin Alberto , Honig Stanton , Kopa Zsolt , Lo Kirk , Nieschlag Eberhard , Page Stephanie T. , Sandlow Jay , Sitruk‐Ware Regine , Swerdloff Ronald S. , Wu Frederick C. W. , Goulis Dimitrios G. 
Published: September 2023

AbstractBackgroundsDespite a wide spectrum of contraceptive methods for women, the unintended pregnancy rate remains high (45% in the US), with 50% resulting in abortion. Currently, 20% of global contraceptive use is male‐directed, with a wide variation among countries due to limited availability and lack of efficacy. Worldwide studies indicate that >50% of men would opt to use a reversible method, and 90% of women would rely on their partner to use a contraceptive. Additional reasons for novel male contraceptive methods to be available include the increased life expectancy, sharing the reproductive risks among partners, social issues, the lack of pharma industry involvement and the lack of opinion makers advocating for male contraception.AimThe present guidelines aim to review the status regarding male contraception, the current state of the art to support the clinical practice, recommend minimal requirements for new male contraceptive development and provide and grade updated, evidence‐based recommendations from the European Society of Andrology (EAA) and the American Society of Andrology (ASA).MethodsAn expert panel of academicians appointed by the EAA and the ASA generated a consensus guideline according to the GRADE (Grading of Recommendations, Assessment, Development and Evaluation) system.ResultsSixty evidence‐based and graded recommendations were produced on couple‐centered communication, behaviors, barrier methods, semen analysis and contraceptive efficacy, physical agents, surgical methods, actions before initiating male contraception, hormonal methods, non‐hormonal methods, vaccines, and social and ethical considerations.ConclusionAs gender roles transform and gender equity is established in relationships, the male contribution to family planning must be facilitated. Efficient and safe male‐directed methods must be evaluated and introduced into clinical practice, preferably reversible, either hormonal or non‐hormonal. From a future perspective, identifying new hormonal combinations, suitable testicular targets, and emerging vas occlusion methods will produce novel molecules and products for male contraception.