bluuebunny/crossref_metadata_2025_split huggingface dataset:
Introducing a method to monitor the impact of introducing value-based payment models; using a Dutch pilot project for coronary artery disease as an example
Authors: Timmermans M.J.C. , Leao D.L.L. , Halfwerk F.R. , Derks L. , Boven W.J. van , Arkenbout E.K. , Groot W. , Veghel H.P.A. van 
Published: August 2023

Abstract
Background:
Worldwide, the usage of value-based payment (VBP) models is increasing. Empirical studies on the intended and unintended effects of the introduction of a VBP model are however scarce. In this study, we present an approach to monitor the effects of the introduction of VBP models. Moreover, we share the results of a first application of the approach using a Dutch outcome-based payment model for coronary artery disease with limited financial impact to participating hospitals as an example.
Methods:
A mixed-method approach was developed and applied. This approach consists of online questionnaires and semi-structured interviews regarding the impact of an outcome-based payment model on treatment decisions, the organization of care, and the importance of clinical outcomes in the planning and control cycle of the hospital. In addition, case-mix analyses with real-world data were performed to monitor whether the risk profile of treated patients changed after the introduction of the payment model. Implicated cardiologists and cardiothoracic surgeons discussed the results.
Results:
The developed approach was implemented successfully. Data were collected and discussed at several time points and led to relevant insights regarding both intended and unintended effects. Fifty-two percent of the respondents on the survey indicated that the VBP model leads to more attention to clinical outcomes within the medical department. Case-mix analyses did not exhibit any signs of risk selection.
Conclusions:
The developed mixed-method approach is a useful tool, as it creates insights into the desired and undesired effects of the introduction of VBP models. The application of the developed model in other contexts can enrich the frame of reference and provide stakeholders with more insight regarding which results are worrisome and which are not.
Determination of the Mineral Composition of the Pulp and Evaluation of the Acute Toxicity of the Seeds of Carica Papaya L. Consumed in Lubumbashi and Kinshasa in the Democratic Republic of the Congo
Authors: Guelord Inkalaba , Magain Mihatano , Arnauld Janvier , Arthur Duki , Olivier Nzingula , Maguy Luvandu , Nicole Misengabu , Kule-Koto Kodondi 
Published: August 2023

Abstract
Background: This work aimed on the one hand to determine the mineral and phytochemical composition of Carica papaya in order to guarantee the food safety of consumers, and on the other hand to evaluate the acute toxicity of papaya seeds.
Methods: The papayas were bought on the Mzee market in Lubumbashi and that of Selembao in Kinshasa. Fruit sampling was done according to the ISO 7002 standard on agricultural and food products; the papayas were firm, mature, without stains or physical damage.
Results: The analysis results of the papaya pulp showed both for the samples from the city of Lubumbashi and for the city province of Kinshasa that it contains respectively 85.87% and 84.46% water; 0.59% and 0.53% ash content. The mineral evaluation of our two samples presented a potassium content of 200±8 mg, magnesium 13.12±3mg, calcium 22.15±2mg, sodium 3mg±0.5 for the sample from Lubumbashi and 192, 32±8mg of potassium, 14.458±3mg of magnesium, 20.58±2mg of calcium and sodium 3.58±0.5mg for the sample from Kinshasa in macroelements. Concerning the trace elements, after analysis we found as zinc content (0.29 ± 0.1 mg and 0.12 ± 0.1 mg), copper (0.02 ± 0.01 mg and 0.14 ± 0.01mg), iron (2.22±0.5 mg and 2.04±0.5 mg) respectively for Lubumbashi and Kinshasa.
The chemical screening indicates the presence of alkaloids, saponosides, tannins catechics, flavonoids and anthocyanins in the palm wine and ethanolic extract of the seeds of Carica papaya and an absence of cyanogenic glycosides and gallic tannins.
Conclusion: With mild toxicity, the seeds of the fruit of Carica papaya L. can be used with moderate risk by the population.
Associations of Methylenetetrahydrofolate reductase (MTHFR) polymorphism with Hepatocellular carcinoma In Egyptian population.
Authors: Abozeid Fatma , zaki Maysaa , nagah wafaa , ragab amany , fathy aya , elhammady dina , ghazy hayam , yaseen ahmed , nomir manal , serria mohamed , Ammar omar , Habeeb Maha 
Published: August 2023

Abstract
Liver serves as a hub for key metabolic pathways such as folate cycle that provides one-carbon units for a network of metabolic reactions. Methylenetetrahydrofolate reductase (MTHFR) is a rate limiting enzyme in folate metabolism and thus it is vital for DNA methylation, synthesis and repair. The objective of this study was to evaluate an eventual association between MTHFR polymorphisms C677T (rs1801133) and A1298C (rs1801131) and the susceptibility to hepatocellular carcinoma (HCC) in Egyptian population. Blood samples from patients and controls from Mansoura university hospital were used after signed consent and approvement from Medical ethical committee. The two genetic loci were designed for amplification and genotyped by using PCR-RFLP. Our results clarify that, the most important predictors for HCC are T/T genotype of variant C677T and C/C genotype of variant (A1298C) with odds ratio 39.756, and 2.012 respectively. Also, MTHFR variant C677T genotype C/C or T/T combined with MTHFR variant A1298C genotype C/C were associated with an increased risk of HCC, with the OR, 2.6 and 7 respectively. CT genotype of MTHFR variant C677T showed significant difference between HCC grades and C allele of variant C677T showed significant difference in BCLC stages of HCC. Our data indicates that, the two variants (C677T and A1298C) constitute a risk factor for the development of HCC and this could be attributed to the low activities of the enzyme MTHFR that disturb one carbon metabolism and subsequently, DNA synthesis, repair and Methylation, cellular redox state, growth, and proliferation.
Theoretical Simulation of TADF Character of 3,9'-Bicarbazole Modified 2,4,6-Triphenyl-1,3,5-triazine
Authors: Zhao Shuyuan , Lin Zhengwen , Wang Fang , Si Zhenjun , Chen Zhe 
Published: August 2023

Abstract

The temperature activated delayed fluorescent (TADF) molecules of 9-(2-(4,6-diphenyl-1,3,5-triazin-2-yl)phenyl)-9H-3,9'-bicarbazole (o-TrzDCz), 9-(3-(4,6-diphenyl-1,3,5-triazin-2-yl)phenyl)-9H-3,9'-bicarbazole (m-TrzDCz) and 9-(4-(4,6-diphenyl-1,3,5-triazin-2-yl)phenyl)-9H-3,9’-bicarbazole (p-TrzDCz) were designed with D-A type molecular structure and their photophysical properties were theoretically simulated in this paper. The calculation of the twist angle between the D and A moieties in ground state and the molecular Root-Mean-Deviaiton (RMSD) of the S1and T1 states referenced to the S0 state indicate that o-TrzDCz possess relatively bigger steric hindrance and stabler molecular configuration. The simulation on the ISC/RISC process revealed that o-TrzDCz possess smaller reorganization energies of 0.06/0.04 eV, which are much smaller than those of m-TrzDCz (0.51/0.41 eV) and p-TrzDCz (1.93/1.06 eV). Finally, o-TrzDCz possess the biggest values of KRISC (7.28×106 s-1) and Kr (3.12×106 s-1) and smallest Kp value of 0.10 s-1 amongst the three titled molecules, indicating that o-TrzDCz should have more excellent TADF character than m-TrzDCz and p-TrzDCz. In a word, this research presents that adjusting the molecular linking manner should be a charming way to explore high efficient TADF molecules.
Fast Numerical Simpson and Boole Integration by Using the Derivatives at the Boundaries
Authors: Engler Michael 
Published: August 2023

Abstract
This article shows the extension of the closed Newton-Cotes numerical integration of Simpson's and Boole's rule by using the odd derivatives of the function at the boundaries of the integration interval. The derivatives can be used to efficiently increase the convergence order of numerical integration and a fast decrease of the error. Furthermore, due to its simplicity, it is very easy to write into program code, which is also shown.
The error estimation is given and proven. Also, the method is confirmed with two different examples for numerical integration, of π and of the integral of the Gaussian distribution. Here, the method is compared to some common numerical integration methods, showing comparably faster convergence.
MSC Classification: 65D30 , 65D32
Spina bifida and cardiorespiratory profile: the impact of leisure sport activities on physical fitness
Authors: Monti Riccardo , Mariani Francesco , Mastricci Rosanna , Nifosì Francesco Maria , Palmieri Vincenzo , Gravina Ester Manes , Capriati Margherita , Rendeli Claudia 
Published: August 2023

Abstract
Purpose
The aim of the present study is to evaluate a population of young patients affected by Spina Bifida (SB) to describe their cardiorespiratory function and bone mineral density profile, analysing any differences between people performing and those who do not perform sports activity. The study also aimed to rule out possible congenital heart disease associated with spina bifida, considering the common origin of certain cardiac structures with those found to be altered in SB patients.
Methods
Thirty-four young patients, aged between 12 and 22 years, diagnosed with spinal dysraphism (SD), have been clinically described and, in order to evaluate their physical fitness, functional capacity and bone mass, almost all of them underwent a complete cardiorespiratory assessment, including Electrocardiogram (ECG), Echocardiogram, Cardiopulmonary Exercise Test (CPET); body composition analysis, using Bioimpedance Analysis (BIA) and Dual Energy X-ray Absorptiometry (DEXA), as well as the estimation of Bone Mineral Density (BMD) with Computerized Bone Mineralometry (CBM).
Results
Collected data demonstrated that only 35% of the subjects practiced physical activity during the week. BMI and percentage FM values were pathological in at least 50% of the population. On cardiological investigations (ECG and echocardiogram), no significant alterations were found. In all patients who performed CPET (79.4%), pathological values of the main functional capacity parameters were revealed, especially peak oxygen consumption (VO2 peak), even when corrected for BCM or FFM estimated at BIA and DEXA respectively. In the CBM analysis, out of 27 patients in whom the femoral T-score was evaluated, a condition of osteopenia was revealed in 40.7% of the patients (11/27) and osteoporosis in 18.5% (5/27); out of 27 patients in whom the lumbar T-score was evaluated, 37% of the patients showed osteopenia (10/27) and 29.6% osteoporosis (8/27). When the comparison between exercising and non-exercising patients was performed, the only statistically significant difference that emerged was the median lumbar T-score value, which appeared lower in the group not performing physical activity (p = 0,009).
Conclusions
The extensive cardiorespiratory evaluation, including CPET, of our cohort of spina bifida patients showed altered values of the main parameters related to cardiorespiratory fitness and is the only study in the literature that analysed bone mineralisation values in physically active and sedentary spina bifida patients and demonstrated a statistically significant difference. Furthermore, it is the only study to date that investigated the possible association of congenital heart diseases with SD, without demonstrating the existence of pathological conditions.
The Second-minimum and Second-maximum Value of Sombor Index in Unicyclic and Bicyclic Graphs
Authors: tan huan , zhao biao 
Published: August 2023

Abstract
Gutman proposed a topological index called the Sombor index, which was defined as \(SO(G)=\sum_{uv\in E(G)}\sqrt{(d_G(u))^2+(d_G(v))^2}\), where \(d_G(v)\) is the degree of the vertex \(v\) in graph \(G\). In this paper, we determine the second-minimum and second-maximum value of the Sombor index over all the unicyclic and bicyclic graphs.
Improving precise point positioning (PPP) performance with best integer equivariant (BIE) estimator
Authors: Yang Yuze , Zhou Feng , Song Shuli 
Published: August 2023

Abstract
Precise point positioning (PPP) technology is capable of providing global high-precision positioning services, but its main application bottleneck is the long convergence time. Accurate and reliable carrier phase ambiguity resolution (AR) is a primary approach to accelerate PPP convergence and improve its accuracy. The best integer equivariant (BIE) method, known for its superior performance in minimizing mean square error (MSE), is gradually being adopted for PPP-AR. This study examines key aspects of the BIE algorithm, including the determination of the optimal number of candidate sets and how the number of candidates evolves during convergence. The performance of the BIE algorithm is evaluated by utilizing both post-processing products and real-time products generated at the French CNES (Centre National D'Etudes Spatiales) with static station data. The experimental results unequivocally demonstrate that the BIE algorithm significantly improves both positioning accuracy and convergence speed compared to the least-squares ambiguity decorrelation adjustment (LAMBDA) algorithm in PPP-AR. Furthermore, a verification experiment using real ship-borne dynamic data confirms the exceptional robustness of the BIE algorithm.
Scale-dependent habitat selection is shaped by landscape context in dispersing white-tailed deer
Authors: Stephens Ryan B. , Millspaugh Joshua J. , McRoberts Jon T. , Heit David R. , Wiskirchen Kevyn H. , Sumners Jason A. , Isabelle Jason L. , Moll Remington J. 
Published: August 2023

Abstract
Context. Identifying how animals select habitat while navigating landscapes is important for understanding behavioral ecology and guiding management and conservation decisions. However, habitat selection may be spatially and temporally plastic, making it challenging to quantify how species use resources across space and time.
Objectives. We investigated how landscape context and dispersal shape habitat selection at multiple spatial scales in white-tailed deer (Odocoileus virginianus).
Methods. Using step-selection functions, we quantified habitat selection of landcover and topographic covariates at three spatial scales for juvenile males during three movement periods (before, during, after dispersal) in two regions of Missouri, USA — a fragmented, low forest cover region with rolling hills, and a forested, topographically variable region.
Results. Although selection for forest cover increased after dispersal in both regions, deer selected forest cover at smaller spatial scales in the fragmented, low forest cover region. This result indicates scale of selection was dependent on forest availability and configuration with deer likely perceiving landscapes differently across their distribution. Functional responses to topography differed in magnitude and direction between regions with deer avoiding roads and selecting valleys in the rolling hills region (especially during dispersal) while showing no response to roads and selecting for ridgelines (during dispersal) in the topographically variable region. This result suggests movement behavior is strongly dependent on topography.
Conclusions. Although deer may select habitats similarly among regions, landscape context and movement period shape the scale, strength, and direction of selection. This result has important implications for how deer use landscapes across different regional contexts.
Research on Deep Learning Based Genetic Intelligent Identification Method for Historical Buildings: A Case Study of Chinese Baroque Architecture in Harbin, China
Authors: Shao Long , Sun Jianqiao 
Published: August 2023

Abstract
The protection of historical buildings is limited by low-quality style imitation and large-scale demolition and reconstruction, and the work process requires a high investment of human and material resources, which restricts the inheritance and development of this material cultural heritage. How to achieve precise monitoring and protection of historical building style is a key issue that needs to be urgently solved. The gene of historical architecture is the basic unit that controls the style of historical architecture. Identifying the gene of historical architecture is to identify the decisive factor that controls the style of historical architecture, which is of great significance for precise monitoring and protection of the style of historical architecture. At present, there are subjective qualitative, difficult to quantify, poor recognition accuracy, and low efficiency in reasoning and recognition in research on genetic identification of historical buildings. Therefore, this article takes the Chinese Baroque architecture in Harbin, China as an example, drawing on the principles of biological gene recognition, referring to the methods of architectural gene recognition in cultural geography and architecture, and using improved U-net models, traditional U-net models, FCN models, and Efficient Net models that incorporate channel attention mechanisms to intelligently identify historical building genes, obtaining the optimal intelligent recognition method for historical building genes based on deep learning. Research has shown that the accuracy of the improved U-net model incorporating channel attention mechanism is 0.69, which is 0.04, 0.07, and 0.01 higher than traditional U-net (0.65), FCN (0.62), and Efficient net (0.68), respectively. Therefore, the improved U-net model is the optimal method for intelligent identification of historical building genes. Research can provide new tools and methods for the intelligent identification of historical building genes.
Thermoring Basis for the Heat Inactivation in TRPV1
Authors: Wang Guangyu 
Published: August 2023

Abstract

Transient receptor potential vanilloid-1 (TRPV1) in mammals exhibits the temperature-dependent inactivation in response to repeated or constant heat stimuli. However, the underlying structural factors or motifs are unresolved. In this computational study, the graph theory-based grid thermodynamic model was employed to reveal how the temperature-dependent non-covalent interactions as identified in the 3D structures of TRPV1 could develop a systemic fluidic grid-like mesh network with topological grids constrained as the thermo-rings to govern the heat inactivation from open and pre-open closed states in different temperature ranges. The results showed that the heat-evoked melting of three biggest grids in different gating states was responsible for the TRPV1 activity starting at 43°C and peaking at 56°C and ending at 61°C. While the second biggest grid controlled a reversible inactivation from the open state between 56°C and 61°C, a smaller grid governed another irreversible inactivation from the pre-open closed state from 43°C to 61°C. Thus, two distinct inactivation pathways of TRPV1 may be involved in a protective mechanism in mammals against noxious heat.
Effect of temperature and salinity on in-vitro population growth of copepode Oithona (Copepoda: Cyclopoidae). Temperature-salinity Oithona culture
Authors: Lambraño Katrina Medina , Forero Adriana Rodríguez 
Published: August 2023

Abstract
The marine copepods culture has been considered a great resource for feeding in marine aquaculture. Oithona is the most abundant genus in the oceans and that is why they are the largest contributors of live prey in fish larvae. The present study aimed to identify the influence of temperature and salinity on the population growth of Oithona sp. under laboratory conditions. Copepods were cultivated (n: 15 ind/200 ml in three experimental temperatures: 21, 26, 31°C and in three salinities: 20, 30, and 40‰), which were monitored and adjusted daily. Copepods were fed based on a microalgae culture Isochrysis sp. at a continuous density of 600.000 cel/ml. for 15 days. At the end of the experiment, Oithona sp presented significant statistical differences (p < 0.05), in population growth, with a higher population density at 40‰ (8.040 ± 6.265.2 ind/ 200ml), at a temperature of 31°C. Also, it was shown that the variable salinity alone did not influence the population growth of the copepod, while, if it was related to the water temperature, it presents statistically significant differences (p < 0.05), in all possible combinations. We concluded that Oithona sp. can be well adapted to higher temperature and salinity conditions in which the optimal salinity and temperature variables rate is 31°C and 40‰ to reach a higher development. These conditions improve the rate of reproduction, population growth, and its development in culture.
Neutrophil-to-Lymphocyte Ratio Associated with Symptomatic Saccular Unruptured Intracranial Aneurysm
Authors: Zheng De-Xiang , Lv Yi-Yang , Zhang Xiao-Jing , Ye Jie-Shun , Zhang Jian-Xing , Chen Cha , Luo Bin , Yan Dan 
Published: August 2023

Abstract
Background and purpose: Whether symptomatic unruptured intracranial aneurysms (UIAs) lead to change in circulating inflammation remains unclear. This study aims to evaluate the role of hematological inflammatory indicators in predicting symptomatic UIA.
Methods: Adult patients diagnosed with saccular intracranial aneurysm from March 2019 to August 2022 were recruited retrospectively. Clinical and laboratory data, including the white blood cells (WBC), neutral counts (NEUT), lymphocyte counts (LYM), and monocyte counts (MONO) of each patient, were collected. The neutrophil-to-lymphocyte ratio (NLR) and lymphocyte-to-monocyte ratio (LMR) were calculated as NLR = NEUT/LYM, LMR = LYM/MONO, SII = PLT*NEUT/LYM. The hematological inflammatory indicators were compared in symptomatic saccular and asymptomatic UIA patients. Multivariable logistic regression analyses were performed to explore the factors predicting symptomatic UIA.
Results: Eighty-eight UIA patients with a mean age of 57.0 ± 11.6 were included, of which 68.2% were females. The NLR and LMR were significantly associated with symptomatic UIA, and the association remained in small UIAs (<7 mm). The multiple logistic regression analysisshowed that NLR was an independent risk factor for symptomatic UIA. On ROC curve analysis, the optimal cutoff value of NLR to differentiate symptomatic from asymptomatic was 2.38. In addition, LMR was significantly associated with symptomatic UIA smaller than 7 mm.
Conclusion: There was a significant correlation between NLR and symptomatic UIA. The NLR was an independent risk factor for symptomatic UIA.
A Study on the Use Choice and Preference Correlation of Inner Perfume in Korean Women
Authors: Son Younsun , Kwon Ki Han 
Published: August 2023

Abstract
Background
The evaluation questionnaire for Korean women's choice of using inner perfume provided relatively promising results. To evaluate reliability, it is to verify correlation studies of preferences.
Methods
An online survey of 507 Korean women in their 20s and 40s who agreed with the purpose of this study and voluntarily expressed their intention to participate was conducted using SPSS win v25.0 to analyze at a 5% significance level. Exploratory factor analysis was conducted and Cronbach's ⍺ was calculated to test the validity and reliability of the study subjects' perceptions and preferences.
Results
The reason why Korean women use Inner Perfume is because they recognize the smell of the Y zone before and after menstruation to hide unpleasant smells. This is a preference for inner perfumes in improving the quality of life of Korean women, which has a positive effect on their use.
Conclusions
Looking at the variables that affect preference, quality (t = 7.458, p < .001) and advertisements (t = 5.738, p < .001) was found to have a significant positive (+) effect on preference, but brands and prices did not have a significant effect on preference (p > .05). Among the variables that have a significant effect, 'quality (=).308) > Advertising (= In the order of '244), preference was found to have a large influence. Therefore, it means that preference improves as quality and advertisement increase.