bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cardiac device-related infective endocarditis need for lead extraction whatever the device according to the ESC EORP EURO-ENDO registry
Authors: Donal Erwan , Tribouilloy Christophe , Sadeghpour Anita , Laroche Cécile , Tude Rodrigues Ana Clara , Pereira Nunes Maria do Carmo , Kang Duk-Hyun , Hernadez-Meneses Marta , Kobalava Zhanna , De Bonis Michele , Dworakowski Rafal , Ivanovic Branislava , Holicka Maria , Kitai Takeshi , Cruz Ines , Huttin Olivier , Colonna Paolo , Lancellotti Patrizio , Habib Gilbert 
Published: July 2023

Abstract

Aims
Cardiac device–related infective endocarditis (CDRIE) is a severe complication of cardiac device (CD) implantation and is usually treated by antibiotic therapy and percutaneous device extraction. Few studies report the management and prognosis of CDRIE in real life. In particular, the rate of device extraction in clinical practice and the management of patients with left heart infective endocarditis (LHIE) and an apparently non-infected CD (LHIE+CDRIE−) are not well described.

Methods and results
We sought to study in EURO-ENDO, the characteristics, prognosis, and management of 483 patients with a CD included in the European Society of Cardiology EurObservational Research Programme EURO-ENDO registry. Three populations were compared: 280 isolated CDRIE (66.7 ± 14.3 years), 157 patients with LHIE and an apparently non-infected CD (LHIE+CDRIE−) (71.1 ± 13.6), and 46 patients with both LHIE and CDRIE (LHIE+CDRIE+) (70.2 ± 10.1). Echocardiography was not always transoesophageal echography (TOE); it was transthoracic echography (TTE) for isolated CDRIE in 88.4% (TOE = 67.6%), for LHIE+CDRIE− TTE = 93.0% (TOE = 58.6%), and for CDRIE+LHIE+ TTE = 87.0% (TOE = 63.0%). Nuclear imaging was performed in 135 patients (positive for 75.6%). In-hospital mortality was lower in isolated CDRIE 13.2% vs. 22.3% and 30.4% for LHIE+CDRIE− and LHIE+CDRIE+ (P = 0004). Device extraction was performed in 62.1% patients with isolated CDRIE, 10.2% of LHIE+CDRIE− patients, and 45.7% of CDRIE+LHIE+ patients. Device extraction was associated with a better prognosis [hazard ratio 0.59 (0.40–0.87), P = 0.0068] even in the LHIE+CDRIE− group (P = 0.047).

Conclusion
Prognosis of endocarditis in patients with a CD remains poor, particularly in the presence of an associated LHIE. Although recommended by guidelines, device extraction is not always performed. Device removal was associated with better prognosis, even in the LHIE+CDRIE− group.
Highly Abundant Proteins Are Highly Thermostable
Authors: Luzuriaga-Neira Agusto R , Ritchie Andrew M , Payne Bryan L , Carrillo-Parramon Oliver , Liberles David A , Alvarez-Ponce David 
Published: July 2023

AbstractHighly abundant proteins tend to evolve slowly (a trend called E-R anticorrelation), and a number of hypotheses have been proposed to explain this phenomenon. The misfolding avoidance hypothesis attributes the E-R anticorrelation to the abundance-dependent toxic effects of protein misfolding. To avoid these toxic effects, protein sequences (particularly those of highly expressed proteins) would be under selection to fold properly. One prediction of the misfolding avoidance hypothesis is that highly abundant proteins should exhibit high thermostability (i.e., a highly negative free energy of folding, ΔG). Thus far, only a handful of analyses have tested for a relationship between protein abundance and thermostability, producing contradictory results. These analyses have been limited by 1) the scarcity of ΔG data, 2) the fact that these data have been obtained by different laboratories and under different experimental conditions, 3) the problems associated with using proteins’ melting energy (Tm) as a proxy for ΔG, and 4) the difficulty of controlling for potentially confounding variables. Here, we use computational methods to compare the free energy of folding of pairs of human–mouse orthologous proteins with different expression levels. Even though the effect size is limited, the most highly expressed ortholog is often the one with a more negative ΔG of folding, indicating that highly expressed proteins are often more thermostable.
Living Alone Increases the Risk of Hypertension in Older Chinese Adults: A Population-Based Longitudinal Study
Authors: Wang Xiang , Yuan Xiangyang , Xia Bin , He Quan , Jie Wei , Dai Miao 
Published: July 2023

Abstract

Background and Objectives
Cross-sectional studies have suggested a potential association between living alone and hypertension risk, but longitudinal evidence remains limited. We aimed to investigate the correlation between living alone, alterations in living arrangements, and hypertension risk among older adults utilizing a population-based longitudinal design.

Research Design and Methods
The study included 8 782 older adults (≥65 years) without hypertension from the Chinese Longitudinal Healthy Longevity Survey. Participants were surveyed during the 2008 and 2011/2012 waves and were subsequently followed up in the next wave. Hypertension was defined as systolic blood pressure ≥140 mmHg and/or diastolic blood pressure ≥90 mmHg, or a self-reported diagnosis of hypertension by a physician. Cox proportional hazards model was used to explore the association between living alone and hypertension. Additionally, we analyzed how switching living arrangements during the follow-up period affects hypertension.

Results
During a median follow-up of 2.8 (1.7–3.0) years, 2 750 hypertension events occurred. Compared with living with family, the hazard ratio (HR) (95% confidence interval [CI]) of living alone was 1.19 (1.06–1.33) for hypertension. Similarly, persisting in living alone during follow-up increased the risk of hypertension compared to continuing to live with family (HR 1.24; 95% CI: 1.06–1.45). Compared to married participants who continued to live with family, widowed/divorced participants who transitioned from living with family to living alone experienced a higher risk of hypertension (HR 1.21; 95% CI: 1.00–1.47). Stratified analyses showed that living alone was only associated with an increased hypertension risk for participants aged &gt;80, men, and rural residents.

Discussion and Implications
Living alone at baseline or persisting in living alone during follow-up correlated with increased hypertension risk. Divorced or widowed individuals who transitioned from living with family to living alone were still at risk. These results indicate that social support and living arrangements may be important in preventing hypertension in older adults.
Efficient real-time selective genome sequencing on resource-constrained devices
Authors: Shih Po Jui , Saadat Hassaan , Parameswaran Sri , Gamaarachchi Hasindu 
Published: July 2023

Abstract

Background
Third-generation nanopore sequencers offer selective sequencing or “Read Until” that allows genomic reads to be analyzed in real time and abandoned halfway if not belonging to a genomic region of “interest.” This selective sequencing opens the door to important applications such as rapid and low-cost genetic tests. The latency in analyzing should be as low as possible for selective sequencing to be effective so that unnecessary reads can be rejected as early as possible. However, existing methods that employ a subsequence dynamic time warping (sDTW) algorithm for this problem are too computationally intensive that a massive workstation with dozens of CPU cores still struggles to keep up with the data rate of a mobile phone–sized MinION sequencer.

Results
In this article, we present Hardware Accelerated Read Until (HARU), a resource-efficient hardware–software codesign-based method that exploits a low-cost and portable heterogeneous multiprocessor system-on-chip platform with on-chip field-programmable gate arrays (FPGA) to accelerate the sDTW-based Read Until algorithm. Experimental results show that HARU on a Xilinx FPGA embedded with a 4-core ARM processor is around 2.5× faster than a highly optimized multithreaded software version (around 85× faster than the existing unoptimized multithreaded software) running on a sophisticated server with a 36-core Intel Xeon processor for a SARS-CoV-2 dataset. The energy consumption of HARU is 2 orders of magnitudes lower than the same application executing on the 36-core server.

Conclusions
HARU demonstrates that nanopore selective sequencing is possible on resource-constrained devices through rigorous hardware–software optimizations. The source code for the HARU sDTW module is available as open source at https://github.com/beebdev/HARU, and an example application that uses HARU is at https://github.com/beebdev/sigfish-haru.
Genome-wide association study identifies multiple HLA loci for sarcoidosis susceptibility
Authors: Liao Shu-Yi , Jacobson Sean , Hamzeh Nabeel Y , Culver Daniel A , Barkes Briana Q , Mroz Margarita , Macphail Kristyn , Pacheco Karin , Patel Divya C , Wasfi Yasmine S , Koth Laura L , Langefeld Carl D , Leach Sonia M , White Elizabeth , Montgomery Courtney , Maier Lisa A , Fingerlin Tasha E ,   GRADs Investigators
Published: July 2023

Abstract
Sarcoidosis is a complex systemic disease. Our study aimed to (1) identify novel alleles associated with sarcoidosis susceptibility; (2) provide an in-depth evaluation of HLA alleles and sarcoidosis susceptibility and (3) integrate genetic and transcription data to identify risk loci that may more directly impact disease pathogenesis. We report a genome-wide association study of 1335 sarcoidosis cases and 1264 controls of European descent (EA) and investigate associated alleles in a study of African Americans (AA: 1487 cases and 1504 controls). The EA and AA cohort was recruited from multiple United States sites. HLA alleles were imputed and tested for association with sarcoidosis susceptibility. Expression quantitative locus and colocalization analysis were performed using a subset of subjects with transcriptome data. Forty-nine SNPs in the HLA region in HLA-DRA, -DRB9, -DRB5, -DQA1 and BRD2 genes were significantly associated with sarcoidosis susceptibility in EA, rs3129888 was also a risk variant for sarcoidosis in AA. Classical HLA alleles DRB1*0101, DQA1*0101 and DQB1*0501, which are highly correlated, were also associated with sarcoidosis. rs3135287 near HLA-DRA was associated with HLA-DRA expression in peripheral blood mononuclear cells and bronchoalveolar lavage from subjects and lung tissue and whole blood from GTEx. We identified six novel SNPs (out of the seven SNPs representing the 49 significant SNPs) and nine HLA alleles associated with sarcoidosis susceptibility in the largest EA population. We also replicated our findings in an AA population. Our study reiterates the potential role of antigen recognition and/or presentation HLA class II genes in sarcoidosis pathogenesis.
Asian conceptions of international order: what Asia wants
Authors: Bajpai Kanti , Laksmana Evan A 
Published: July 2023

Abstract
How do major Asian states regard the current international security order? Do they agree or disagree among themselves? This is an introduction to a special section on ‘Asian conceptions of international order: what Asia wants’. It draws on articles analysing the stances of China, India, Japan, South Korea, Indonesia, Malaysia, Singapore, Thailand, Philippines and Vietnam towards the existing international security order usually described as a liberal international order (LIO). It argues that Asian states substantially support the main constitutive and regulatory norms and institutions of the LIO, but they worry that the LIO does not consistently honour these norms. Asians disagree on the centrality of political liberalism, but even Japan and South Korea, the most liberal states, are uncomfortable with strident criticism, punishment and the exclusion of less liberal states. Asians also disagree on the role of US alliances: some are strongly supportive, some are ambivalent and some are negative. Finally, Asians disagree on how they voice dissatisfaction. Japan and South Korea supplement existing norms and institutions as a way of transcending the limitations of the LIO; south-east Asian states promote ASEAN's mediatory role for peace and security above and beyond existing global arrangements; and Indonesia, India and China want to move from being norm takers to becoming norm shapers. The introduction ends with six policy implications.
Fabricating a war? Russian (dis)information on Ukraine
Authors: Johansson-Nogués Elisabeth , Şimanschi Elena 
Published: July 2023

Abstract
Propaganda has been an age-old part of warmongering. It is thus no surprise that the Russian invasion of Ukraine was preceded by, and continues to be fuelled by, propaganda transmitted by state-controlled Russian media. What is more unusual about the Russian (dis)information campaigns is the sheer volume of distorted narratives or complete fictional accounts about the conflict. This article explores the content and technologies of Russian information manipulation of domestic audiences in the context of the invasion of Ukraine. We also examine the bases for the sustained robust public support for the war within Russia during the first 12 months of the conflict, despite being based on mostly fabricated (dis)information. Relying on political psychology and communication theory we explain how emotions and associative memories have played an important role in the Russian public's sustained approval to the war. Our findings point to that in the absence of contrasted and independently-verified information, the volume, frequency, emotional intensity of slick, plug-and-play media packages on Ukraine have acted to displace and distort the average Russian's associative social monitoring processes.
Diel vertical migration in Pacific sand lance (Ammodytes personatus)—a pelagic forage fish associated with benthic substrates
Authors: Baker Matthew R , Smeltz T S , Williams Kresimir , Greufe Casey , Ewing Megan , Chapman Jonathan , Glassy Julia , Hasegawa Eva , Cieri Kathleen P , Matson Sofia , Towler Rick 
Published: July 2023

AbstractDiel vertical migration (DVM) in marine organisms is an evolved response to maximize foraging opportunities and minimize predation risk. This pattern in vertical distribution is a widely observed phenomenon and common in pelagic forage fish species. Modelling these dynamics has important relevance to understanding marine ecosystem dynamics, predator–prey interactions, and marine food webs. We examine DVM in sand lance—an ecologically important taxa of forage fishes throughout northern hemisphere marine systems and target of commercial fisheries. Much remains unknown about their diurnal emergence from sediments. We apply data from autonomous stereo-camera deployments and tank observations to provide new insight to DVM patterns in Pacific sand lance (Ammodytes personatus). We model emergence curves using beta regression models with random effects, depicting important differences in the shape of ascent and descent. Our observations and analyses document crepuscular movement patterns, suggesting pelagic foraging occurs primarily at dawn and dusk. Results suggest critical light thresholds are necessary to initiate and maintain pelagic foraging. Results also suggest the importance of seasonality and life stage, such that adult fish exhibit reduced pelagic foraging in the fall relative to juvenile fish. These results constitute a comprehensive evaluation of DVM in this species, better define the physical drivers, and mathematically depict the pattern and shape of emergence timing.
Genetic analyses of nutrient digestibility measured by fecal near-infrared spectroscopy in pigs
Authors: Hov Martinsen Kristine , Thingnes Signe Lovise , Wallén Sini Elena , Mydland LivTorunn , Afseth Nils Kristian , Grindflek Eli , Meuwissen Theodorus Hendrikus Elisabeth 
Published: July 2023

Abstract
Improved nutrient digestibility is an important trait in genetic improvement in pigs due to global resource scarcity, increased human population and greenhouse gas emissions from pork production. Further, poor nutrient digestibility represents a direct nutrient loss, which affects the profit of the farmer. The aim of this study was to estimate genetic parameters for apparent total tract digestibility of nitrogen (ATTDn), crude fat (ATTDCfat), dry matter (ATTDdm), and organic matter (ATTDom) and to investigate their genetic relationship to other relevant production traits in pigs. Near-infrared spectroscopy was used for prediction of total nitrogen content and crude fat content in feces. The predicted content was used to estimate apparent total tract digestibility of the different nutrients by using an indicator method, where acid insoluble ash was used as an indigestible marker. Average ATTDdm, ATTDom, ATTDn, and ATTDCfat ranged from 61% to 75.3%. Moderate heritabilities was found for all digestibility traits and ranged from 0.15 to 0.22. The genetic correlations among the digestibility traits were high (&gt;0.8), except for ATTDCfat, which had no significant genetic correlation to the other digestibility traits. Significant genetic correlations were found between ATTDn and feed consumption between 40 and 120 kg live weight (F40120) (−0.54 ± 0.11) and ATTDdm and F40120 (−0.35 ± 0.12) and ATTDom and F40120 (−0.28 ± 0.13). No significant genetic correlations were found between digestibility traits and loin depth at 100 kg, nor backfat thickness at 100 kg (BF), except between BF and ATTDn (−0.31 ± 0.14). These results suggested that selection for improved feed efficiency through reduced feed intake within a weight interval, also has led to improved ATTDdm, ATTDom, and ATTDn. Further, the digestibility traits are heritable, but mainly related to feed intake and general function of the intestines, as opposed to allocation of feed resources to different tissues in the body.
A C-type lectin in saliva of Aedes albopictus (Diptera: Culicidae) bind and agglutinate microorganisms with broad spectrum
Authors: Lin Zimin , Cheng Jinzhi , Mu Xiaohui , Kuang Xiaoyuan , Li Zhiqiang , Wu Jiahong 
Published: July 2023

Abstract
Via complex salivary mixture, mosquitos can intervene immune response and be helpful to transmit several viruses causing deadly human diseases. Some C-type lectins (CTLs) of mosquito have been reported to be pattern recognition receptor to either resist or promote pathogen invading. Here, we investigated the expression profile and agglutination function of an Aedes albopictus CTL (Aalb_CTL2) carrying a single carbohydrate-recognition domain (CRD) and WND/KPD motifs. The results showed that Aalb_CTL2 was found to be specifically expressed in mosquito saliva gland and its expression was not induced by blood-feeding. The recombinant Aalb_CTL2 (rAalb_CTL2) could agglutinate mouse erythrocytes in the presence of calcium and the agglutinating activity could be inhibited by EDTA. rAalb_CTL2 also displayed the sugar binding ability to D-mannose, D-galactose, D-glucose, and maltose. Furthermore, it was demonstrated that rAalb_CTL2 could bind and agglutinate Gram positive bacteria Staphylococcus aureus and Bacillus subtilis, Gram negative bacteria Escherichia coli and Pseudomonas aeruginosa, as well as fungus Candida albicans in vitro in a calcium dependent manner. However, rAalb_CTL2 could not promote type 2 dengue virus (DENV-2) replication in THP-1 and BHK-21 cell lines. These findings uncover that Aalb_CTL2 might be involved in the innate immunity of mosquito to resist microorganism multiplication in sugar and blood meals to help mosquito survive in the varied natural environment.
Population structure of Phanaeus vindex (Coleoptera: Scarabaeidae) in SE Michigan
Authors: Wassmer Thomas , Armstrong Elise 
Published: July 2023

Abstract
Until now, little is known about the population structure and mobility of temperate dung beetles including the rainbow scarab, Phanaeus vindex (MacLeay 1819), although this knowledge is essential for their conservation as pastures become increasingly rare and the landscape fragmented by monocultures and urbanization. Here, we estimated population size, longevity, and dispersal within and between pastures. For 3 yr, we life-trapped beetles every week on 2 adjacent farms in SE Michigan, determined their sex, male morph, and size, and marked their elytra with individual tattoo patterns before releasing them. We marked a total of 470 rainbow scarabs of which 14 were recaptured once and 2 were recaptured twice. The sex ratio was not significantly sex-biased but fluctuated between months with no apparent uniformity between years. While the minor to major male ratios were unbiased in 2019 and 2020, they were marginally minor-biased in 2021. The gross population estimates for the 2 farms were 458–491 and 217 rainbow scarabs, respectively. Beetles traveled distances of up to 178 m within farms. No beetles dispersed between farms. One large female was recaptured after 338 days documenting the first cold hardiness and long lifespan of a cold-temperate dung beetle species in the wild. The low population estimates on both farms indicate 2 vulnerable populations with no or extremely limited connectivity. Supplementary funding for the land stewardship of small-scale cattle farmers could stabilize populations of native dung beetles and maintain their ecosystem services.
What’s the Harm in Cardiopulmonary Resuscitation?
Authors: Koch Peter M 
Published: July 2023

Abstract
In clinical ethics, there remains a great deal of uncertainty regarding the appropriateness of attempting cardiopulmonary resuscitation (CPR) for certain patients. Although the issue continues to receive ample attention and various frameworks have been proposed for navigating such cases, most discussions draw heavily on the notion of harm as a central consideration. In the following, I use emerging philosophical literature on the notion of harm to argue that the ambiguities and disagreement about harm create important and oft-overlooked challenges for the ethics of CPR. I begin by elucidating the standard account of harm, called the Counterfactual Comparative Account (CCA). I then show that three challenges to the CCA—preemptive harms, the harm of death, and non-experiential harms—are particularly salient when assessing potential harms for candidates of CPR and likely impact-related decision-making and communication. I extend this argument to explore how the ambiguities of harm might extend to other realms of clinical decision-making, such as the use and limitations of life-sustaining treatments. To address these challenges, I propose two strategies for identifying and minimizing the impact of such uncertainty: first, clinicians and ethicists ought to promote pluralistic conversations that account for different understandings of harm; second, they ought to invoke harm-independent considerations when discussing the ethics of CPR in order to reflect the nuances of such conversations. These strategies, coupled with a richer philosophical understanding of harm, promise to help clinicians and ethicists navigate the prevalent and difficult cases involving patient resuscitation and many other harm-based decisions in the clinical setting.