bluuebunny/crossref_metadata_2025_split huggingface dataset:
Authoritative Parenting and Adolescents’ Digital Citizenship Behaviors: Sequential Mediation of Parental Fairness and Self-Disclosure
Authors: Morales-Álvarez Agustín , Valdés-Cuervo Angel Alberto , Parra-Pérez Lizeth Guadalupe , Grijalva-Quiñonez Christian Samhir 
Published: June 2023

Abstract
Background.
Parenting-related factors are associated with adolescents’ online behavior. However, the relationship between the adopted parenting style and digital citizenship behaviors, as well as the variables underlying this relationship, needs to be clarified. Hence, this study examined the relationship between authoritative parenting and digital citizenship behaviors and explored the mediating roles of perceived parental fairness and self-disclosure in adolescents.
Methods.
A total of 709 Mexican (52% female, M = 14.6, SD = 1.90) middle and high school students in northwest and southwest Mexico were recruited for this study. Latent structural equation modeling was performed to assess the direct and indirect relationships between variables controlling for gender.
Results.
The results showed a positive association between authoritative parenting, parental fairness, self-disclosure, and digital citizenship behavior. In addition, parental fairness, self-disclosure, and digital citizenship behaviors. In addition, parental fairness and self-disclosure partially mediated the association between authoritative parenting and digital citizenship.
Conclusions.
These findings suggest that authoritative parenting and adolescents’ perceptions of parental fairness play an important role in adolescents' self-disclosure and development of digital citizenship behaviors.
A study conducted in breast cancer cells found that (valproic acid) inhibits CIP2A/C-MYC/PI3K/Akt/mTOR signaling molecules and PD-L1
Authors: Zeinali Elahe , Bagheri Vahid , Rostami Esmaeil , mansouri atena , Sarab Gholamreza Anani 
Published: June 2023

Abstract
Background
Resistant cells are a critical problem that reduce treatment efficacy of breast cancer. Nowadays, CIP2A and PD-L1 are considered as theraputical challenges in breast cancer, because of responsible for drug resistance and immune evasion respectively. Hence, identifying agents to suppress these factors is great of interest. Specifically, epigenetic drugs can be an effective approach to alter the behavior of genes.
Objective
The objective of this study is to evaluate the drug effects and molecular mechanisms of valproic acid (VPA) as a HDAC inhibitor, particularly its effect on CIP2A and PD-L1 in breast cancer MCF-7 cell line.
Materials and Methods
In this study, MCF-7 cells were treated with various concentration of VPA for 24 h, 48 h, and 72 h. The rate of cell viability was measured by MTT assay. Finally, gene expressions of CIP2A, c-MYC, PI3K, Akt, mTOR and PD-L1 were analyzed by real time PCR and ΔCT method.
Result
VPA showed a growth inhibitory effect in MCF-7 cell line. This effect is achieved by decreasing the expression levels of CIP2A oncogene and its downstream signaling molecules i.e. c-MYC, PI3K, Akt and mTOR. In addition to being a CIP2A targeting agent, VPA also inhibits PD-L1 in MCF-7 cell line.
Conclusions
Our findings suggest that VPA can be a novel approach to combat with challenges caused by CIP2A and PD-L1, thereby alone or in combination with existing therapies could be promising strategy to get more efficiencies in treatments for breast cancer patients.
Protocol for an ABT study: the role of emotional processing in Art Brut therapy for college students during the COVID-19 pandemic
Authors: Liang Qianrong , Zhong Weiwei , Ye Jiarong , Qiu Hongzhong , Dong Junjie , Shen Heyong 
Published: June 2023

Abstract
Background
COVID-19 is both a global health emergency and a major psychological crisis event, and its negative effects on college students' mental health continue to persist after more than three years. Previous studies[1, 2] suggest that the overall psychological health status of students in colleges has been poor during the COVID-19 pandemic, especially among those vulnerable to emotional problems. Interventions are needed to improve the psychological health of college students. This study was designed to determine the potential role of art brut therapy as a positive psychological health approach for university students.
Methods
A sample of university students (n = 120) will be recruited and assigned to an Offline Art Brut Group (OFABG), Online Art Brut Group (OABG), or a control group (CG) with no intervention. Prior to inclusion in the Time 1 assessment, potential subjects will be screened for eligibility requirements via an online survey. Once recruited, participants will finish the Time 1 assessment; then, the two experimental groups will receive art brut therapy once a week for 16 weeks. After the 16-week intervention, subjects will complete the Time 2 assessment. Every assessment will include both psychological and physiological measures. Symptom Checklists 90 (SCL-90) and the Positive Affect and Negative Affect Scale (PANAS) will be used to measure the psychological effects of art brut therapy in college students, while the level of cortisol in saliva samples and interleukin 6 (IL-6) in blood samples will be used to examine the physiological effects.
Discussion
This study will articulate the impact of art brut therapy on both psychological conditions and physiological markers associated with emotions, and it will also explore the feasibility and effectiveness of online art brut therapy. The results will determine the efficacy of a low-cost, easy-to-implement, accessible and engaging psychological health intervention for university students with emotional challenges during the COVID-19 pandemic.
Trial registration Chinese Clinical Trial Registry, ChiCTR2200062802, August 19th, 2022.
Tyrosinase Enzyme Purification and Immobilization from Pseudomonas sp. EG22 Using Cellulose Coated Magnetic Nanoparticles: Characterization of Bioactivity in Melanin Product
Authors: El-Aziz Salim Mohamed Abd , Faraag Ahmed Hassan Ibrahim , Ibrahim Ayman Meselhi , Albrakati Ashraf , Bakkar Marwa Reda 
Published: June 2023

Abstract
Melanin is a brown-black pigment produced by a variety of organisms and has significant roles in various biological processes such as insect cuticle sclerotization, wound healing, and fruit ripening. The tyrosinase enzyme catalyzes the conversion of tyrosine to melanin. Research on this enzyme and its derivatives has revealed promising uses in the pharmaceutical and biotechnology sectors. The aim of this research is to purify and immobilize the tyrosinase enzyme from Pseudomonas sp. EG22 using cellulose-coated magnetic nanoparticles. Various techniques, such as UV-visible spectroscopy, transmission electron microscopy (TEM), Zeta Sizer Nano ZS, and FTIR, were utilized to examine the synthesized nanoparticles. According to the findings, the nanoparticles exhibited a spherical shape with an average diameter of 12 nm. Furthermore, they possessed a negative surface charge, as evidenced by a polydispersity index (PDI) of 0.260 and a surface potential of -55.7 mV. The antibacterial and anticancer bioactivity of the enzyme's melanin product is also investigated. Results of the study indicated optimum tyrosinase activity at pH 6 and 35°C and increased with increasing tyrosine concentration. The results indicate that by immobilizing the tyrosinase enzyme on cellulose coated magnetic nanoparticles, its stability can be improved, enabling longer usage. Moreover, this method could prove beneficial in increasing the production of melanin. Produced melanin showed potential antibacterial activity against multi-drug resistant strain of Citrobacter freundii. The potential of melanin pigment to decrease cell survival and induce apoptosis in initiation cells was demonstrated. When treated with the IC50 concentration, HepG2 cells showed reduced resistance to melanin pigment.
Pulsatile tinnitus relieved by ear pressure case report
Authors: Kmeid Elio , Romanos Michael , Faddoul Sami 
Published: June 2023

Abstract
This study presents a rare case of pulsatile tinnitus. A middle-aged woman presented with new-onset pulsatile tinnitus that resolves upon applying pressure anterior to the helix root. Upon detailed physical exam, we observed congestion and hyperermia on the affected side. CT angiography of the head and neck revealed an arteriovascular malformation along the temporal artery. The patient underwent successful treatment with endovascular embolization.
The Skin Microbiome Stratifies Patients with Cutaneous T Cell Lymphoma and Determines Event-Free Survival
Authors: Licht Philipp , Dominelli Nazzareno , Kleemann Johannes , Pastore Stefan , Müller Elena-Sophia , Haist Maximilian , Hartmann Kim Sophie , Stege Henner , Bros Matthias , Meissner Markus , Grabbe Stephan , Heermann Ralf , Mailänder Volker 
Published: June 2023

Abstract

Background: Cutaneous T cell lymphomas (CTCL) are a heterogeneous group of non-Hodgkin lymphomas that are characterized by the presence of clonal malignant T cells in the skin, with Mycosis fungoides (MF) being the most common entity. The role of the skin microbiome for MF development and progression are currently poorly understood.
Methods: We used shotgun metagenomic profiling, real-time qPCR and T cell receptor sequencing to compare lesional and nonlesional skin of 20 patients with early and advanced MF that were treated at two independent German skin cancer centres. Additionally, Staphylococcus aureus and other bacterial species were isolated from MF skin for functional profiling and to investigate the S. aureus virulence factor spa.
Results: We identified a subgroup of MF patients that exhibited a substantial dysbiosis on MF lesions with concomitant outgrowth of S. aureuson plaque while the other MF patients presented with a balanced microbiome on lesional skin. Dysbiosis and S. aureus outgrowth were accompanied with ectopic levels of cutaneous antimicrobial peptides (AMPs) and increased adaptation of the outgrowing, plaque-derived S. aureus strains, which may have resulted in or contributed to these microbiome perturbations. Furthermore, the plaque-derived S. aureus strains showed a reduced susceptibility towards antibiotics and an upregulation of the virulence factor spa, which also exhibited a potential gain-of-function mutation, that may render it highly potent to activate the NF-κB pathway. Last, we observed a restricted T cell receptor repertoire and a reduced event-free survival in patients with dysbiosis on MF lesions.
Conclusions: Our data suggest that virulent, outgrowing S. aureus strains fuel pathogenesis in the MF patient subgroup with dysbiosis, possibly via highly potent spa that activates the NF-κB pathway. We therefore provide a solid basis for the role of the skin microbiome for MF progression and pave the way for potential microbiome modulating treatments specifically targeting S. aureus to prevent MF disease progression.
Comparison of Machine Learning Algorithms for Predicting Traffic Accident Severity (Case Study: United Kingdom from 2010 to 2014)
Authors: Rezashoar Soheil , Kashi Ehsan , Saeidi Soheila 
Published: June 2023

Abstract
One of the social problems is that a large number of people lose their lives on the roads in traffic crashes every year. Accidents with high costs, social and cultural consequences affect human societies. This article has considered the geographical characteristics, speed, pavement, weather, lighting, date and time, the purpose of travel, vehicle specifications, etc., to classify the severity of slight and fatal_serious accidents occurring on the highways of Britain. In this paper, python and machine learning algorithms were used after receiving the relevant data on the kaggle website, about 252 thousand records, and 32 independent variables between 2010 and 2014. The results showed that Naïve Bayes (Total) with an accuracy of 75.10%, Support Vector Machine with an accuracy of 75.05%, and Neural Network with an accuracy of 74.59% were predicted with reasonable accuracy. The proposed algorithms of this paper can be used by most departments and traffic and transportation organizations of the country as practical tools for decision-making to use and implement road safety methods. Indeed, in circumstances where it is impossible to experience practical issues due to economic and technical constraints, these models represent reality and provide an understanding of how the system behaves.
Effect of Nano-BN on Friction and Wear Properties of AlN Plate
Authors: Xiong Sang , Zhang Jiaxi , Wu Chao 
Published: June 2023

Abstract
Nano-BN/Si, BN/Al2O3 composite lubricants was prepared by a hydrothermal stirring synthesis method. Orthogonal experiments were conducted by changing the mass fraction of Si and Al2O3. Extreme pressure and wear resistance performance of nano-BN lubricants was investigated the four-ball machine method, and the effect of nano-BN on the friction and wear performance of AlN plates were studied by the multifunctional friction and wear tests. SEM, EDS and XPS were used to characterize the wear morphology and element distribution on the wear surface of the steel balls and the sliding AlN plates, the wear and friction mechanism of nano-BN/Si, BN/Al2O3 as anti-wear additives contained in the nanocomposite lubricants between the metal friction pairs was proposed. The excellent tribological performance of the BN composite lubricants attribute to the synergistic effect between nano-Si particles or Al2O3 particles and layered nano-BN particles, which accelerates the formation of solid lubrication film composed of BN, Si, Al2O3 and Fe2O3 on the surface of the AlN plate, thus reducing the wear between friction pairs.
Small target detection algorithm based on attention mechanism and data augmentation
Authors: Wang Jiuxin , Liu Man , Su Yaoheng , Yao Jiahui , Du Yurong , Zhao Minghu , Lu Dingze 
Published: June 2023

Abstract

The detection of masks is of great significance to the prevention of occupational diseases such as infectious diseases and dust diseases. For the problems of small target size, large number of targets, and mutual occlusion in mask-wearing detection, a mask-wearing detection algorithm based on improved YOLOv5s is proposed in present work. First, the ultra-lightweight attention mechanism module ECA was introduced in the Neck layer to improve the accuracy of the model. Second, the influence of different loss functions (GIoU, CIoU, and DIoU) on the improved model was explored, and CIoU was determined as the loss function of the improved model. Besides, the improved model adopted the label smoothing method at the data processing stage, which effectively improved the generalization ability of the model and reduced the risk of overfitting. Finally, the influence of data augmentation methods (Mosaic and Mixup) on model performance was discussed, and the optimal weight of data augmentation was determined. The proposed model was tested on the verification set and the mean precision (mAP), precision, and recall are 92.1%, 90.3%, and 87.4%, respectively. The mAP of the improved algorithm is 4.4% higher than that of the original algorithm.
Seasonality and light: drivers of abundance, species richness, and diversity in the soil seed bank of a woodland savanna
Authors: Silva-Zagatto Solange do Santos , Weiser Veridiana de Lara 
Published: June 2023

Abstract
Understanding the composition of the soil seed bank, as well as the influence of seasonality and light on seed germination, is crucial for comprehending how changes in these conditions impact the recruitment of new individuals in the aboveground community, the dynamics of natural regeneration, and responses to disturbances. In this study, we investigated the effects of seasonality and light on the abundance, species richness, and diversity of the soil seed bank. The study was conducted in the woodland savanna of Glebe II, located within the Aimorés Wildlife Refuge, which is part of the Mosaic of Conservation Units of São Paulo State Savanna, in southeastern Brazil. We analyzed the soil seed bank using the seedling emergence method in both dry and rainy seasons. Soil was collected from 25 permanent plots, divided equally. One part was placed for germination in a nursery with a polyethylene screen cover, providing 14% shading (light treatment), while the other part was placed in a nursery with a polyethylene screen cover, providing 70% shading (shady treatment). Abundance, species richness, and diversity were evaluated for each season and treatment. Our results revealed greater abundance and species richness in the soil seed bank collected during the rainy season and maintained under shady treatment. In contrast, we observed greater diversity in the soil seed bank collected during the dry season and maintained under light treatment. These findings demonstrate that seasonality and light conditions have distinct effects on different attributes of the soil seed bank in the woodland savanna.
Sports despite masks: No negative effects of FFP2 face masks on cardiopulmonary exercise capacity in children
Authors: Weigelt Annika , Schöffl Isabelle , Rottermann Kathrin , Wällisch Wolfgang , Müller³ Sarina Katrin , Dittrich Sven , Hübner Matthias Jens 
Published: June 2023

Abstract
Introduction:
Face masks were recognized as one of the most effective ways for preventing the spread of the COVID-19-virus in adults, the benefits of wearing those were extended to children and adolescents and led to limited physical education (PE) lessons or cancellation of them. This further decreased the amount of physical activity available to children and adolescents during the pandemic. However, there is little published data on the potential adverse effects on wearing the most effective and partially mandatory FFP2/N95 face-masks during PE or physical activity (PA) in this age. Even though the pandemic has been declared as passed by the WHO, the rise of a new pandemic and thus the use of face-masks for limiting its spread is inevitable, so we need to be prepared in a better way for alternative options to lockdown and limitation of PA in such a scenario.
Material and Methods
20 healthy children aged 8–10 years performed two identical cardiopulmonary exercise tests as an incremental step test on a treadmill within an interval of two weeks, one time without wearing a protective mask and one time wearing a FFP2 mask. The cardiopulmonary exercise parameter and especially the endexpiratory gas exchange for oxygen and carbon dioxide (petO2 and petCO2) were documented for each step, at rest and 1 minute after reaching physical exhaustion.
Results
12 boys (mean age 8.5 ± 1.4 years) and 8 girls (mean age 8.8 ± 1.4 years) showed no adverse events until maximal exertion. The mean parameters measured at peak exercise did not differ significantly between both examinations (mean Peak VO2 = 42.7 ± 9.5 vs 47.8 ± 12.9 ml/min/kg, mean O2pulse 7.84 ± 1.9 ml/min vs. 6.89 ± 1.8, mean VE/VCO2slope 33.4 ± 5.9 vs. 34.0 ± 5.3). The most significant difference was the respiratory exchange rate (RER, 1.01 ± 0.08 vs 0.95 ± 0.08). The measured respiratory gases (end tidal O2 and CO2) decreased respectively increased significantly into nearly each step wearing an additional FFP2-mask without reaching levels of hypercapnia or hypoxia.
Conclusion
In this study, no significant differences of the cardiorespiratory function at peak exercise could be discerned when wearing a FFP2/N95 face mask. While the end-tidal values for CO2 increased significantly and the end-tidal values for O2 decreased significantly, these values did never reach pathological levels. Furthermore, the children terminated the exercise at a lower RER and heart rate (HR) suggesting a subconscious awareness of the higher strain. Since the detrimental effects of limiting sports during the pandemic are well documented, stopping PE lessons altogether because of the minor physiological effects wearing these masks instead of simply stopping pushing children to perform at their best seems premature and should be reconsidered in the future.
Preoperative Cross-Sectional Area and Thickness of Pancreatic Stump as Possible Predictors of Pancreatic Fistula and Pseudocyst following Laparoscopic Distal Pancreatectomy: A Retrospective Study
Authors: Obana Ayato , Sato Yoshinobu , Iwasaki Kenichi , Koyama Motoi , Suwa Tatsushi 
Published: June 2023

Abstract
Purpose
This retrospective study investigates the association between the preoperative radiographic measurements of pancreatic thickness, cross-sectional area and the postoperative outcomes in laparoscopic distal pancreatectomy (DP) patients.
Methods
A total of 27 patients who underwent DP between May 2019 and February 2022 were included. Preoperative thoracoabdominal computed tomography (CT) measurements of pancreatic thickness and cross-sectional area were analyzed for their potential role in predicting postoperative pancreatic fistula (POPF) and pseudocyst formation.
Results
Our findings revealed a significant correlation between pancreatic thickness and amylase levels in the drain fluid on postoperative day one (POD1). Furthermore, pancreatic thickness emerged as a robust predictor for the formation of postoperative pancreatic pseudocysts. Notably, no significant association was observed between the cross-sectional area of the pancreas and either the drain amylase levels or pseudocyst formation.
Conclusions
These findings accentuate the potential role of preoperative CT evaluation, specifically the measurement of pancreatic thickness, in predicting the risk of POPF and pseudocyst formation after DP. It can contribute to tailored perioperative procedures and strategic patient management, ultimately enhancing patient outcomes. The present study underscores the importance of incorporating radiographic assessments into preoperative planning for patients undergoing DP.
Online Learning Experience of University Students during the COVID-19 Pandemic Quarantine in Greece
Authors: Andrie Elisabeth K. , Kostaki Evangelia – Georgia , Sakellari Evanthia , Leontopoulou Sophie , Lagiou Areti 
Published: June 2023

Abstract

Purpose. The aim of the study was to develop and validate an instrument for exploring students'skills and beliefs about online learning experience during COVID-19 pandemic and to investigate sociodemographic characteristics associated with students’ skills and believes of online learning.
Methods. A 15-item questionnaire was developed and administered to 1,103 undergraduate students at University of West Attica and University of Ioannina during 2021. The survey requested demographic and socioeconomic information and information related to online learning beliefs and skills during the COVID-19 pandemic. Factor analysis, estimation of factors’ reliability and validity and univariable and multivariable linear regression analysis were carried out using Stata 13.1 and SPSS 23.0 programs.
Results. A total of 1.103 valid questionnaires were retrieved. 73.6% of the students were females, 56.8% aged 18-21 years old and 95.9% had Greek nationality. Factor analysis identified 2 factors, interpreted as “general beliefs about online learning,” and “acquisition of skills”. The Cronbach alpha of the instrument was 0.934. Multivariable regression analysis showed that males, students aged > 21 years old, those with Greek nationality and those who were very satisfied with their living conditions during quarantine reported having more confidence in prerequisite “skills”. Moreover, students aged > 21 years old, those studying non-health sciences, those who were very satisfied with their living conditions and those whose decision concerning their place of residence was influenced by health reasons related to the pandemic and financial reasons, had more positive “beliefs” about online learning.
Conclusions. Our study will help decision-makers understand students' attitudes and motivation toward online learning and improve ongoing online courses.