bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Signal of Post Catch-up in Open Innovation Dynamics
Authors: Yun Jinhyo Joseph , Zhao Xiaofei , Jeong Euiseub , Kim Sangwoo , Kim Kyunghun , Hahm Sung Deuk 
Published: April 2023

The digital transformation can serve as a window of opportunity for those late-comers who are equipped with the capability to create complementary assets for grabbing new opportunities of technological leapfrogging as a way of catch-up while penalising the forerunner. In this context, we want to answer the following research question. Is there any difference in open innovation effect on the firm according to the changing of belonging sectorial innovation system from catch-up to post-catch-up? We statistically analysed the moderating effects of open innovation between catching-up, and the performance with the patents which were registered in United States Patent and Trademark Office, which were applied from China in telecommunication, from South Korea in Semiconductors, and from Japan in biotechnology on 1995–1999, and 2005–2009. We found three results from this study: first, from this research, as the signal of post catching-up, open innovation effects on the performance of firm, and the moderating effects of open innovation between catching-up, and the performance of the firm were found; second, the appearance of new dominant design after post catching-up was explained through the powerful open innovation and third, open innovation could be a useful new strategy for firms in the post catching-up to use.
Association of Screen Time with Physical and Mental Health Among Children: A Cross-Sectional Study
Authors: Donthu Raj Kiran , Badabagni Raghava , Mohammed Abdul Salaam , Vuddandam Krishna Varsha , Chatti Veena Saraswathi 
Published: April 2023

Background: The effects of digital screen use on the physical and mental health of a child are a debated area of research. Studies have established few harmful effects, but the usage among children remains to be high. There is less understanding of the pattern of the digital screen and application usage and its impact on physical and mental health in our population. Aims: To study the pattern of digital screen use among children (5-15 years) and its impact on their physical and mental health. Setting and design: Cross-sectional study conducted in a tertiary care hospital. Materials and Methods: Sociodemographic details of parents and their children, screen time-related questions, pediatric symptom checklist (PSC) for screening of mental health issues, and questions regarding physical health issues in children due to screen use. Statistical Analysis: Data was analyzed using R language. Results: There is a significant association between parents’ education, gender, and the number of children with screen time. YouTube followed by WhatsApp are the commonly used digital applications and smartphones followed by Smart TVs are the commonly used digital gadgets. The physical issues are less than the clinical cut-off values but significantly associated with screen time. Sleep disturbance and avoiding outdoor activity are frequently reported due to screen use. Conclusion: The study highlights the common usage pattern of various digital gadgets and applications among children and their parents; also the demographic factors of parents relating to increased screen time in children. There are no significant clinical mental health issues reported by parents, but a significant association is found between digital screen use with physical and mental health issues.
From Godown to Warehouse Management: Transformation at eKart, An Illustrative Case Study
Authors: Kumar Anita , Asthana Smriti 
Published: April 2023

The growth in Ecommerce has transformed warehouse and distribution centers to mega-fulfilment centers. The focus is increasingly on innovative storage solutions, better tracking mechanisms coupled with technology and training. Companies who do not realize this have little chance of surviving (Rachid Fergati, MD Indian subcontinent, UPS). The purpose of this case is to highlight the process, people, and operations improvements undertaken by an Indian e-commerce giant with the help of the research team at the CII School of Logistics for enhanced efficiency and customer service. The researchers spent 50 days onsite (at the company’s warehouse located in Binola) observing the processes, identifying issues, providing solutions, and tracking and recording improvements as per the action research methodology (Reason, 2001). Thus, two-fold objectives were achieved: (a) improved cost efficiency and material handling processes in the warehouse and (b) knowledge building in the strategic operations management area. The case is a representative illustration of how the Indian logistics industry is moving from fragmented, unorganized, and inefficient systems to a more organized, structured sector in an ultra-competitive global space.
The correlation between falls efficacy and activities of daily living among older adults receiving different types of care: a 2018–2019 cross-sectional study in Shanghai, China
Authors: Wang Jian , Zhao Qi , Li Zhipeng , Jen Ting Yi 
Published: April 2023

Abstract
Background
Falls in older adults has become a significant public health concern worldwide. Falls-related self-efficacy is closely related to healthy aging. This study investigated older adults receiving different types of care to clarify the correlation between falls efficacy and Activies of Daily Living (ADL), providing a theoretical basis for achieving healthy aging.

Methods
An investigation comparing older adults attending senior day care centers and healthy older adults staying at home in the community was carried out by using structured questionnaires, including individual participants’ data, Falls Efficacy Scale International (FES-I), Patient Health Questionnaire-9, Generalized Anxiety Disorder Scale-7 and Lawton Instrumental Activities of Daily Living Scale (Lawton IADLs).

Results
A total of 336 older adults were enrolled, and 153 (45.5%) older adults attending senior day care centers daily. The FES-I score of all the respondents was 30.65 ± 13.892, while the scores of healthy older adults staying at home in the community and attending senior day care centers were 25.05 ± 10.036 and 37.35 ± 14.894, respectively (p < 0.05). Among healthy older adults staying at home in the community, those using walking aids (OR = 53.595, 95%CI: 8.181, 351.129), with fear of falling (OR = 5.909, 95%CI:1.374, 25.407) and with anxiety symptoms (OR = 23.620, 95%CI: 6.077, 91.802) had low falls efficacy. Among older adults attending senior day care centers daily, those with higher education levels had high falls efficacy (OR = 0.276, 95%CI: 0.088, 0.862), and those with poor sleep quality (OR = 4.469, 95%CI: 0.682, 29.312), comorbidities (OR = 9.820, 95%CI: 1.990, 48.456), and with severe depressive symptoms (OR = 3.680, 95%CI: 1.098, 12.335) had low falls efficacy. The older adults with a higher score of Lawton IADLs had higher falls efficacy.

Conclusions
Older adults attending senior day care centers daily had lower falls efficacy and needed to be paid more attention to in fall prevention. Targeted health promotion activities were necessary for older adults to improve their falls efficacy to achieve healthy aging.
Nurses’ rationale for underreporting of patient and visitor perpetrated workplace violence: a systematic review
Authors: Spencer Cara , Sitarz Jamie , Fouse June , DeSanto Kristen 
Published: April 2023

Abstract
Background
Patient and visitor perpetrated workplace violence (WPV) is a problem within healthcare and is known to be underreported by nurses and other healthcare workers. However, there are multiple and diverse reasons identified in the literature as to why nurses do not report. This systematic review aimed to investigate nurses’ reasons and rationale related to underreporting of violence that occurs in the workplace.

Methods
Following PRISMA guidelines for systematic review reporting, studies conducted between 2011 and early 2022 were identified from MEDLINE, CINAHL, APA PsychInfo, and Psychological and Behavioral Sciences Collection via EBSCOHost. Quantitative studies related to patient and visitor perpetrated violence containing explanations, reasons, or rationale related to underreporting were included.

Results
After quality appraisals, 19 studies representing 16 countries were included. The resulting categories identified nursing, management, and organizational factors. The most prominent nursing factors included nurses’ fear of consequences after reporting, nurses’ perceptions, and their lack of knowledge about the reporting process. Common management factors which contributed to nursing underreporting included lack of visible changes after reporting, non-supportive culture in which to report, and the lack of penalties for perpetrators. Organizational factors included the lack of policies/procedures/training for WPV, as well as a lack of an efficient and user-friendly reporting system. Supportive interventions from management, organizations, and community sources were summarized to provide insight to improve nurse reporting of WPV events.

Conclusion
Underreporting of WPV is a complex and multi-faceted problem. An investigation into the rationale for underreporting a workplace violent event illustrates nurses, management, and organizations contribute to the problem. Clear and actionable interventions such as educational support for staff and the development of a clear and concise reporting processes are recommended to encourage staff reporting and to help address WPV in healthcare.
Effects of BOPPPS combined with TBL in surgical nursing for nursing undergraduates: a mixed-method study
Authors: Li Zhiying , Cai Xiaoyan , Zhou Kebing , Qin Jieying , Zhang Jiahui , Yang Qiaohong , Yan Fengxia 
Published: April 2023

Abstract
Background
Surgical Nursing is a core subject for nursing undergraduates that requires active and effective learning strategies to cultivate students’ autonomous learning competencies and critical thinking. The effects of BOPPPS (Bridge-in, Objectives, Pretest, Participatory Learning, Post-test and Summary) model combined with team-based learning (TBL) have rarely been explored in Surgical Nursing courses.

Objective
To explore the effects of BOPPPS combined with TBL in Surgical Nursing for nursing undergraduates.

Methods
A mixed research method of quasi-experimental study design and descriptive qualitative research was used. The control group included 27 nursing undergraduates who had finished the Surgical Nursing course using traditional learning. The experimental group included 36 nursing undergraduates were enrolled in to receive the Surgical Nursing course in the teaching mode of BOPPPS combined with TBL. The quantitative data of students’ Surgical Nursing final scores, autonomous learning competencies and critical thinking ability of the two groups were collected and compared by t-test. Qualitative results were obtained through semi-structured interviews and data were analyzed by thematic analysis method.

Results
Compared with the traditional learning mode, BOPPPS combined with TBL significantly improved nursing students’ final examination scores, autonomous learning competencies and critical thinking ability (p < 0.05). Qualitative results from 14 undergraduate nursing students’ interviews were summarized into five themes: (1) stimulating learning interest; (2) improving autonomous learning ability; (3) improving the sense of teamwork; (4) exercising critical thinking; and (5) suggestions for improvement.

Conclusions
The combination of BOPPPS and TBL positively impacted nursing students by improving their autonomous learning competencies and critical thinking ability. The study suggests BOPPPS combined with TBL learning as an effective, alternative learning mode.
Downregulation of the RNA-binding protein PUM2 facilitates MSC-driven bone regeneration and prevents OVX-induced bone loss
Authors: Yoon Dong Suk , Choi Yoorim , Lee Kyoung-Mi , Ko Eun Ae , Kim Eun-Ji , Park Kwang Hwan , Lee Jin Woo 
Published: April 2023

Abstract
Background
Although mRNA dysregulation can induce changes in mesenchymal stem cell (MSC) homeostasis, the mechanisms by which post-transcriptional regulation influences MSC differentiation potential remain understudied. PUMILIO2 (PUM2) represses translation by binding target mRNAs in a sequence-specific manner.

Methods
In vitro osteogenic differentiation assays were conducted using human bone marrow-derived MSCs. Alkaline phosphatase and alizarin red S staining were used to evaluate the osteogenic potential of MSCs. A rat xenograft model featuring a calvarial defect to examine effects of MSC-driven bone regeneration. RNA-immunoprecipitation (RNA-IP) assay was used to determine the interaction between PUM2 protein and Distal-Less Homeobox 5 (DLX5) mRNA. Ovariectomized (OVX) mice were employed to evaluate the effect of gene therapy for postmenopausal osteoporosis.

Results
Here, we elucidated the molecular mechanism of PUM2 in MSC osteogenesis and evaluated the applicability of PUM2 knockdown (KD) as a potential cell-based or gene therapy. PUM2 level was downregulated during MSC osteogenic differentiation, and PUM2 KD enhanced MSC osteogenic potential. Following PUM2 KD, MSCs were transplanted onto calvarial defects in 12-week-old rats; after 8 weeks, transplanted MSCs promoted bone regeneration. PUM2 KD upregulated the expression of DLX5 mRNA and protein and the reporter activity of its 3'-untranslated region. RNA-IP revealed direct binding of PUM2 to DLX5 mRNA. We then evaluated the potential of adeno-associated virus serotype 9 (AAV9)-siPum2 as a gene therapy for osteoporosis in OVX mice.

Conclusion
Our findings suggest a novel role for PUM2 in MSC osteogenesis and highlight the potential of PUM2 KD-MSCs in bone regeneration. Additionally, we showed that AAV9-siPum2 is a potential gene therapy for osteoporosis.
Impacts of dual active-ingredient bed nets on the behavioural responses of pyrethroid resistant Anopheles gambiae determined by room-scale infrared video tracking
Authors: Gleave Katherine , Guy Amy , Mechan Frank , Emery Mischa , Murphy Annabel , Voloshin Vitaly , Towers Catherine E. , Towers David , Ranson Hilary , Foster Geraldine M. , McCall Philip J. 
Published: April 2023

Abstract
Background
The success of insecticide treated bed nets (ITNs) for malaria vector control in Africa relies on the behaviour of various species of Anopheles. Previous research has described mosquito behavioural alterations resulting from widespread ITN coverage, which could result in a decrease in net efficacy. Here, behaviours were compared including timings of net contact, willingness to refeed and longevity post-exposure to two next-generation nets, PermaNet® 3.0 (P3 net) and Interceptor® G2 (IG2 net) in comparison with a standard pyrethroid-only net (Olyset Net™ (OL net)) and an untreated net.

Methods
Susceptible and resistant Anopheles gambiae mosquitoes were exposed to the nets with a human volunteer host in a room-scale assay. Mosquito movements were tracked for 2 h using an infrared video system, collecting flight trajectory, spatial position and net contact data. Post-assay, mosquitoes were monitored for a range of sublethal insecticide effects.

Results
Mosquito net contact was focused predominantly on the roof for all four bed nets. A steep decay in activity was observed for both susceptible strains when P3 net and OL net were present and with IG2 net for one of the two susceptible strains. Total mosquito activity was higher around untreated nets than ITNs. There was no difference in total activity, the number, or duration, of net contact, between any mosquito strain, with similar behaviours recorded in susceptible and resistant strains at all ITNs. OL net, P3 net and IG2 net all killed over 90% of susceptible mosquitoes 24 h after exposure, but this effect was not seen with resistant mosquitoes where mortality ranged from 16 to 72%. All treated nets reduced the willingness of resistant strains to re-feed when offered blood 1-h post-exposure, with a more pronounced effect seen with P3 net and OL net than IG2 net.

Conclusion
These are the first results to provide an in-depth description of the behaviour of susceptible and resistant Anopheles gambiae strains around next-generation bed nets using a room-scale tracking system to capture multiple behaviours. These results indicate that there is no major difference in behavioural responses between mosquito strains of differing pyrethroid susceptibility when exposed to these new ITNs under the experimental conditions used.
The activation of mTOR signalling modulates DNA methylation by enhancing DNMT1 translation in hepatocellular carcinoma
Authors: Chen Mengke , Fang Yi , Liang Meinong , Zhang Ning , Zhang Xinyue , Xu Lixia , Ren Xuxin , Zhang Qingfeng , Zhou Yufeng , Peng Sui , Yu Jun , Zeng Judeng , Li Xiaoxing 
Published: April 2023

Abstract
Background
Both dysregulation of mechanistic target of rapamycin (mTOR) signalling and DNA methylation patterns have been shown to be closely associated with tumor progression and serve as promising targets for hepatocellular carcinoma (HCC) therapy. Although their respective roles in HCC have been extensively revealed, the existence of molecular interactions between them remains largely unknown.

Methods
The association of DNA methylation and mTOR signalling in HCC tissues and cell lines was assessed. A Kaplan‒Meier analysis was applied to estimate the overall survival (OS) and recurrence-free survival (RFS) of HCC patients. The modulation of DNMT1 by mTOR in HCC cell lines was determined. The effect of the drug combination in cell lines and mouse models was examined.

Results
The results showed that the DNA methylation level was positively associated with the activation of mTOR signalling in HCC tissues and cell lines. Moreover, HCC patients with higher DNA methylation levels and enhanced activation of mTOR signalling exhibited the worst prognosis. Then, we screened methylation-related enzymes and found that the activation of mTOR signalling increased DNMT1 expression and activity. In addition, mTOR enhanced the translational efficiency of DNMT1 in a 4E-BP1-dependent manner, which is based on the pyrimidine rich translational element (PRTE)-containing 5′UTR of DNMT1. Moreover, we demonstrated that the combined inhibition of mTOR and DNMT synergistically inhibited HCC growth in vitro and in vivo.

Conclusions
In addition to some already identified pro-cancer downstream molecules, the activation of mTOR signalling was found to promote DNA methylation by increasing the translation of DNMT1. Furthermore, combined targeting of mTOR and DNMT1 has been demonstrated to have a more effective tumor suppressive function in HCC.
Single inhalation exposure to polyamide micro and nanoplastic particles impairs vascular dilation without generating pulmonary inflammation in virgin female Sprague Dawley rats
Authors: Cary Chelsea M , Seymore Talia N , Singh Dilpreet , Vayas Kinal N , Goedken Michael J , Adams Samantha , Polunas Marianne , Sunil Vasanthi R , Laskin Debra L , Demokritou Philip , Stapleton Phoebe A 
Published: April 2023

AbstractBackgroundExposure to micro- and nanoplastic particles (MNPs) in humans is being identified in both the indoor and outdoor environment. Detection of these materials in the air has made inhalation exposure to MNPs a major cause for concern. One type of plastic polymer found in indoor and outdoor settings is polyamide, often referred to as nylon. Inhalation of combustion-derived, metallic, and carbonaceous aerosols generate pulmonary inflammation, cardiovascular dysfunction, and systemic inflammation. Additionally, due to the additives present in plastics, MNPs may act as endocrine disruptors. Currently there is limited knowledge on potential health effects caused by polyamide or general MNP inhalation.ObjectiveThe purpose of this study is to assess the toxicological consequences of a single inhalation exposure of female rats to polyamide MNP during estrus by means of aerosolization of MNP.MethodsBulk polyamide powder (i.e., nylon) served as a representative MNP. Polyamide aerosolization was characterized using particle sizers, cascade impactors, and aerosol samplers. Multiple-Path Particle Dosimetry (MPPD) modeling was used to evaluate pulmonary deposition of MNPs. Pulmonary inflammation was assessed by bronchoalveolar lavage (BAL) cell content and H&E-stained tissue sections. Mean arterial pressure (MAP), wire myography of the aorta and uterine artery, and pressure myography of the radial artery was used to assess cardiovascular function. Systemic inflammation and endocrine disruption were quantified by measurement of proinflammatory cytokines and reproductive hormones.ResultsOur aerosolization exposure platform was found to generate particles within the micro- and nano-size ranges (thereby constituting MNPs). Inhaled particles were predicted to deposit in all regions of the lung; no overt pulmonary inflammation was observed. Conversely, increased blood pressure and impaired dilation in the uterine vasculature was noted while aortic vascular reactivity was unaffected. Inhalation of MNPs resulted in systemic inflammation as measured by increased plasma levels of IL-6. Decreased levels of 17β-estradiol were also observed suggesting that MNPs have endocrine disrupting activity.ConclusionsThese data demonstrate aerosolization of MNPs in our inhalation exposure platform. Inhaled MNP aerosols were found to alter inflammatory, cardiovascular, and endocrine activity. These novel findings will contribute to a better understanding of inhaled plastic particle toxicity.
Triggers of self-focused attention: an ecological momentary assessment study
Authors: Nanamori Mao , Tomita Nozomi , Kametani Chiaki , Matsuda Naomi , Kumano Hiroaki 
Published: April 2023

Abstract
Background
Self-focused attention (SFA) is a major maintenance factor of social anxiety disorder. The two types of SFA, the observer perspective and self-focus on body sensation, increase anxiety in individuals with high levels of social anxiety. However, the triggers of each SFA remain unclear. This study used ecological momentary assessment to identify the factors that elicit SFA in real-life social scenarios.

Methods
The study obtained 316 samples from 22 Japanese university students (4 male:18 female) with high social anxiety who completed momentary measures of stimulus perception and two types of SFA for 10 days. Links to online questionnaires were sent to the participants via e-mails 3 times a day. First, multilevel single regression analyses were used to identify the stimuli that induced the two types of SFA. Between-level interaction with gender was done to determine the effect of gender biasing on the female participants. Next, for the variables that were significantly predictive in these analyses, multilevel multiple regression analyses were conducted with fear of each stimulus as a control variable.

Results
Perception of gaze, evaluation, and authority predicted SFA from the observer perspective. Perception of gaze also predicted self-focus on body sensation. In addition, the perception of positive response and that of stranger predicted self-focus on body sensation depended on gender, implying that the positive response perception of female participants predicted self-focus on body sensation. After controlling for corresponding fear, gaze perception predicted both SFAs, and the perception of authority predicted SFA from the observer perspective. In addition, after controlling for relevant fear, the perception of positive response of female participants predicted self-focus on body sensation. In contrast, the fear of evaluation but not the perception of evaluation predicted SFA from the observer perspective.

Conclusions
The perception of gaze is the most powerful trigger of the two types of SFA, even after controlling for fear of gaze in real-life social scenarios for individuals with social anxiety. SFA from the observer perspective is also triggered by the perception of authority and fear of evaluation. The role of perception of positive responses or strangers should be re-evaluated after correcting for gender imbalance. (350 words / 350 words)