bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk Factors and Hospital Outcomes of Acute Kidney Injury in Patients Operated on for an acquired Valvular Heart Disease
Authors: Kremneva L. V. , Suplotov S. N. , Gapon L. I. , Shalaev S. V. 
Published: January 2023

Aim To determine predictors of acute kidney injury (AKI) related with surgeries for correction of acquired valvular heart disease (HD) and to evaluate the incidence of in-hospital complications in patients with postoperative AKI.Material and methods This study included 62 patients after surgery for correction of acquired valvular HD (mean age, 61±10.9 years) with a disease duration of 11±5.3 years. NYHA functional class (FC) 1 chronic heart failure (CHF) was observed in 1.6 % of patients, FC 2 in 64.5 %, and FC 3 in 33.9 %.17.7% of patients had chronic kidney disease (CKD). Coronary lesions of ≥50 % of vascular lumen were detected in 27.4 % of patients. Surgical correction of mitral valvular disease was performed in 32 cases, aortic valvular disease in 36 cases, tricuspid valvular disease in 8 cases, and combined operations for correction of valvular disease and coronary bypass in 8 cases. Creatinine concentrations were measured according to the Jaffe method; glomerular filtration rate (GFR) was estimated with the CKD-EPI equation. AKI was diagnosed based on KDIGO (2012) criteria.Results The AKI incidence related with surgeries for correction of valvular HD was 16.1 % (8.1 % of patients had stage 1 AKI, 3.2 % had stage 2 AKI, and 4.8 % had stage 3 AKI), and 3.2% required kidney replacement therapy. AKI was associated with the presence of CKD at baseline (р=0.044), development of hemopericardium requiring drainage (р=0.012), more pronounced coronary lesions (in the AKI group: stenoses from 50 to 70 % in 20% of patients, from 70 to 90 % in 30 % of patients, and ≥90 % in 0 %; without AKI: from 50 to 70 % in 13.4 % of patients, from 70 to 90 % in 3.8 %, and ≥90 % in 5.8 % of patients, respectively; р=0.032). Probability of postoperative AKI significantly increased with the development of hemopericardium requiring drainage. Patients with postoperative AKI compared to persons without AKI had higher mortality (20 % and 0 %; р=0.001), greater incidence of decompensated CHF (40 and 9.6 %; р=0.012) and hemopericardium requiring drainage (30 and 1.9 %; р=0.012).Conclusion The development of postoperative AKI is associated with CKD at baseline, more pronounced coronary injury, and hemopericardium requiring drainage.
Electrocardiogram QRS Complex Duration as a Predictor of Hospital Prognosis in Patients With COVID-19
Authors: Kovtyukh I. V. , Baymukanov A. M. , Gendlin G. E. , Nikitin I. G. , Dvornikova S. N. , Roginko Olga 
Published: January 2023

Aim To determine the effect of major electrocardiographic (ECG) parameters on the prognosis of patients with COVID-19.Material and methods One of systemic manifestations of COVID-19 is heart injury. ECG is the most simple and available method for diagnosing the heart injury, which influences the therapeutic approach. This study included 174 hospitalized patients with COVID-19. Major ECG parameters recorded on admission and their changes before the discharge from the hospital or death of the patient, were analyzed, and the effect of each parameter on the in-hospital prognosis was determined. Results were compared with the left ventricular ejection fraction (LV EF), laboratory data, and results of multispiral computed tomography (MSCT) of the lungs.Results ECG data differed on admission and their changes differed for deceased and discharged patients. Of special interest was the effect of the QRS complex duration at baseline and at the end of treatment on the in-hospital survival and mortality rate. The Cox regression analysis showed that the QRS complex duration (relative risk (RR) 2.07, 95% confidence interval (CI): 1.17–3.66; р=0.01), MSCT data (RR, 1.54; 95 % CI: 1.14–2.092; р=0.005), and glomerular filtration rate (GFR) (RR, 0.98; 95 % CI: 0.96–0.99; р=0.001) had the highest predictive significance. In further comparison of these three indexes, the QRS duration and GFR retained their predictive significance, and a ROC analysis showed that the cut-off QRS complex duration was 125 ms (р=0.001). Patients who developed left bundle branch block (LBBB) in the course of disease also had an unfavorable prognosis compared to other intraventricular conduction disorders (р=0.038). The presence of LBBB was associated with reduced LV EF (р=0.0078). The presence of atrial fibrillation (AF) significantly predetermines a worse outcome both at the start (р=0.011) and at the end of observation (р=0.034). A higher mortality was observed for the group of deceased patients with ST segment deviations, ST elevation (р=0.0059) and ST depression (р=0.028).Conclusion Thus, the QTc interval elongation, LBBB that developed during the treatment, AF, and increased QRS complex duration are the indicators that determine the in-hospital prognosis of patients with COVID-19. The strongest electrocardiographic predictor for an unfavorable prognosis was the QRS complex duration that allowed stratification of patients to groups of risk.
Cross sectional analytical study – Analytical morphometric study of dry femur in South Gujarat
Authors: Desai Utsavi Devang , Udania Alka , Desai Purvi , Kotha Haripriyanka , Shajan Shino 
Published: January 2023

The femur is the longest, heaviest, and strongest bone in the human body. Morphometric study of femur can be useful for estimation of stature, prediction of femur fractures/pathologies, operative management as well as for determination of congenital anomalies. 250 dry femur bones collected from bone Store, Government Medical College, Surat, Gujarat with study done over a period of 6 months. Total length of each femur and the Foraminal Index (FI) for each nutrient foramina were obtained. The mean total length of femur obtained was 41.22 cms. Torsion angle for both right sided as well as left sided femurs was most common in the range 11 - 14. 39.7% (48) of the total right sided femurs (121) had a torsion angle in the range 11 - 14 while 41.9% (54) of the total left sided femurs (129) also had a torsion angle in the range 11 - 14. Maximum number had a neck shaft angle in the range of 123 - 127 which constitutes 41.6% (104) of total sample size. Nutrient foramina was most commonly (48.8%) along linea aspera with most had a size corresponding to 22 gauge, which constitutes 45.7% (119) of total sample size. Morphometric study of femur helps us to determine various factors which could be helpful for prediction, prevention and diagnosis of a certain pathology as well as for its management and treatment.
Producción de chile habanero (Capsicum chinense Jacq.) en lombricomposta con fertilización orgánica
Authors: Javier-López Leonel , Palacios-Torres Rogelio Enrique , Ramírez-Seañez Ana Rosa , Hernández-Hernández Hipólito , Antonio-Luis María del Carmen , Yam-Tzec José Antonio , Chaires-Grijalva Martha Patricia 
Published: January 2023

El uso indiscriminado de la fertilización química en la producción agrícola, ha ocasionado daños de consideración al medio ambiente, por tal motivo se buscan alternativas de producción orgánica, que tenga efectos positivos en el rendimiento y calidad de los cultivos. El objetivo de la presente investigación fueevaluar el uso de diferentes sustratos en el crecimiento, rendimiento y calidad de fruto del chile habanero híbrido Chichen Itzá en invernadero, estableciendo cuatro tratamientos con los siguientes sustratos y sus mezclas: T1: lombricomposta al 100% con manejo orgánico (ORG-LOM); T2: mezcla de lombricomposta: sueloregional: grava en proporción 1:1:1 (v/v/v) con manejo orgánico (ORG-LSG); T3: mezcla de lombricomposta: arena de río: grava en proporción 1:1:1 (v/v/v) con manejo orgánico (ORG-LAG); y como testigo T4: arena de río con manejo químico (QUIM-AR). El experimento se estableció bajo un diseño de bloques completos alazar. El tratamiento ORG-LOM fue el que mostró los mejores resultados, altura promedio de planta de 192.6 cm, diámetro de tallo de 19.1 mm, número de floresy frutos de 33.84 y 35.8% respectivamente del total obtenido, y rendimiento por planta de 616.41 g, además, el peso de fruto fue de 7.8 g, con longitud de 35.7 mm, diámetro de 25.76 mm, grosor de pericarpio de 2.08 mm y número de lóculos de 3.44. En todas las variables evaluadas el tratamiento con sustrato lombricomposta al 100% y manejo orgánico (ORG-LOM) fue el que mejores resultados obtuvo.
Densidad de madera de especies arbóreas dominantes de la selva tropical subperennifolia de Calakmul, México
Authors: Chan-Coba Gabriel , De Jong Bernardus Hendricus Jozeph , González-Valdivia Noel Antonio , López-Hernández Juan Carlos , Morales-Ruiz Danilo Enrique , Venegas-Venegas José Apolonio , Reyes-Sosa Mariela , Aryal Deb Raj 
Published: January 2023

La densidad de madera es un parámetro fundamental para la estimación precisa de biomasa arbórea en ecosistemas forestales. La selva subperennifolia del sureste mexicano se caracteriza por la alta diversidad arbórea, por lo cual es necesario estudiar las variaciones de densidad de madera. El objetivo del estudio fue determinar la variación de densidad de madera de las especies dominantes de la selva subperennifolia y generar modelos de regresión con el grosor diamétrico de madera. Se colectaron 3 260 muestras de madera de 23 especies, en tres categorías diamétricas (gruesa, mediana y delgada). Se midió el volumen de madera con la técnica de desplazamiento de fluidos y se determinó la masa seca en un horno a 70 ºC por 72 horas. La densidad de madera secalculó como la proporción de masa entre volumen. La densidad de madera varió significativamente entre las especies, siendo la mayor Gymnanthes lucida Sw., con 0.85 g/cm3 y la menor Bursera simaruba (L.) Sarg, con 0.37 g/cm3. El análisis de regresión demostró que 20 de 23 especies presentaron una relación positiva entre la densidad de madera y el tamaño diamétrico. Se concluyó que la densidad de la madera varia por especies y tamaño diamétrico del árbol en estos ecosistemas forestales. Los resultados son útiles para modelar la dinámica de acumulación de biomasa arbórea de la vegetación primaria y secundaria que se encuentra enconstantes cambios en su estructura y composición de especies.
Pengembangan Media Articulate Storyline Berbasis Problem Solving untuk Meningkatkan Kemampuan Pemecahan Masalah Siswa SMP pada Materi Tekanan Zat
Authors: Ratnasari Erma , Syahmani Syahmani , Hafizah Ellyna 
Published: January 2023

Penelitian ini dilatarbelakangi oleh rendahnya kemampuan pemecahan masalah siswa. Penelitian ini bertujuan untuk menghasilkan media pembelajaran articulate storyline berbasis problem solving pada materi tekanan zat yang valid dan praktis sehingga layak digunakan dalam kegiatan pembelajaran. Model yang digunakan dalam pengembangan ini adalah model ADDIE (analyze, design, development, implementation, evaluation). Instrumen pengumpulan data yang digunakan yaitu lembar validasi media, lembar validasi soal, angket keterbacaan dan angket respon siswa. Hasil validasi media dan soal dihitung menggunakan persamaan rumus Aiken’s V dan memperoleh nilai berturut-turut sebesar 0,85 dan 0,84 dengan kriteria validitas tinggi serta percentage of agreement dihitung menggunakan persamaan rumus menurut Borich dan memperoleh nilai berturut-turut sebesar 84,30% dan 88,90% dengan kriteria konsisten dan sangat konsisten. Hasil kepraktisan media articulate storyline berbasis problem solving ditinjau dari angket keterbacaan dan angket respon siswa, memperoleh nilai berturut-turut sebesar 94,50% dan 93,60% dengan kriteria sangat praktis. Maka dapat disimpulkan bahwa media articulate storyline berbasis problem solving layak digunakan dalam pembelajaran materi tekanan zat.
DNA-bridging by an archaeal histone variant via a unique tetramerisation interface
Authors: Ofer Sapir , Blombach Fabian , Erkelens Amanda , Barker Declan , Schwab Samuel , Smollett Katherine , Matelska Dorota , Fouqueau Thomas , Vis Nico van der , Kent Nicholas , Dame Remus , Werner Finn 
Published: January 2023

Abstract
In eukaryotes, histone paralogues form obligate heterodimers such as H3/H4 and H2A/H2B that assemble into octameric nucleosome particles. Archaeal histones are dimeric and assemble on DNA into ‘hypernucleosome’ particles of varying sizes with each dimer wrapping 30 bp of DNA. These are composed of canonical and variant histone paralogues, but the function of these variants is poorly understood. Here, we characterise the structure and function of the histone paralogue MJ1647 from Methanocaldococcus jannaschii that has a unique C-terminal extension enabling MJ1647 homotetramerisation. The 1.9 Å X-ray structure of a dimeric MJ1647 species, structural modelling of the tetramer, and site-directed mutagenesis reveal that the C-terminal tetramerization module consists of two alpha helices in a handshake arrangement. Unlike canonical histones like M. jannaschii A3, MJ1647 tetramers can bridge two DNA molecules in vitro. Using single-molecule tethered particle motion and DNA binding assays, we show that MJ1647 tetramers bind ~60 bp DNA and compacts DNA in a highly cooperative manner. We furthermore show that MJ1647 effectively competes with the transcription machinery to block access to the promoter in vitro. Our results reveal MJ1647 as the first histone with DNA bridging properties, which has important implications for genome structure and gene expression in archaea.
Quantum Variational Rewinding for Time Series Anomaly Detection
Authors: Baker Jack , Horowitz Haim , Radha Santosh , Fernandes Stenio , Jones Colin , Noorani Noorain , Skavysh Vladimir , Lamontagne Philippe , Sanders Barry 
Published: January 2023

Abstract
Electron dynamics, financial markets and nuclear fission reactors, though seemingly unrelated, all produce observable characteristics evolving with time. Within this broad scope, departures from normal temporal behavior range from academically interesting to potentially catastrophic. New algorithms for time series anomaly detection (TAD) are therefore certainly in demand. With the advent of newly accessible quantum processing units (QPUs), exploring a quantum approach to TAD is now relevant and is the topic of this work. Our approach - Quantum Variational Rewinding, or, QVR - trains a family of parameterized unitary time-devolution operators to cluster normal time series instances encoded within quantum states. Unseen time series are assigned an anomaly score based upon their distance from the cluster center, which, beyond a given threshold, classifies anomalous behaviour. After a first demonstration with a simple and didactic case, QVR is used to study the real problem of identifying anomalous behavior in cryptocurrency market data. Finally, multivariate time series from the cryptocurrency use case are studied using IBM’s Falcon r5.11H family of superconducting transmon QPUs, where anomaly score errors resulting from hardware noise are shown to be reducible by as much as 20% using advanced error mitigation techniques.
Statin prevents cancer development in chronic inflammation by blocking interleukin 33 expression
Authors: Park Jong Ho , Mortaja Mahsa , Son Heehwa , Azin Marjan , Wang Jun , Collier Michael , Mandinova Anna , Semenov Yevgeniy , Mino-Kenudson Mari , Demehri Shadmehr 
Published: January 2023

Abstract
Chronic inflammation is a major cause of cancer worldwide. Interleukin 33 (IL-33) is a critical initiator of cancer-prone chronic inflammation; however, its induction mechanism by the environmental causes of chronic inflammation is unknown. Herein, we demonstrate that Toll-like receptor (TLR)3/4-TBK1-IRF3 pathway activation links environmental insults to IL-33 induction in the skin and pancreas. FDA-approved drug library screen identified pitavastatin as an effective IL-33 inhibitor by blocking TBK1 membrane recruitment/activation through the mevalonate pathway inhibition. Accordingly, pitavastatin prevented chronic pancreatitis and its cancer sequela in an IL-33-dependent manner. IRF3-IL-33 axis was highly active in chronic pancreatitis and its associated pancreatic cancer in humans. Interestingly, pitavastatin use correlated with a significantly reduced risk of chronic pancreatitis and pancreatic cancer in patients. Our findings demonstrate that blocking the TBK1-IRF3 signaling pathway suppresses IL-33 expression and cancer-prone chronic inflammation. Statins present a safe and effective therapeutic strategy to prevent chronic inflammation and its cancer sequela.
Concurrent assessment on blood lead in young children and toy lead in Shanghai
Authors: Peng Jiayu , Gao Zhenyan , Xu Jian , Lin Yanfen , Specht Aaron J , Chen Shuwen , Nie Linda H , Huang Linhua , Yan Chonghuai 
Published: January 2023

Abstract
Since toys are the potential sources of lead contamination for young children, we aim to compare blood lead levels (BLLs) of young children and lead-levels in toys played by the children. A total of 2249 children under 7 years old were investigated using stratified cluster sampling in 6 districts of Shanghai, their parents completed questionnaires and children’s whole blood was collected, and then BLLs were measured using tungsten atomizer absorption spectrophotometer. At the same time, 294 toys from the 6 supermarkets/ toy-stores located in the surrounding 5 districts were collected using stratified cluster sampling and lead levels in toys were measured by a portable X-ray Fluorescence instrument. The geometric mean of the BLLs was 2.02 μg/dL. After adjusting for related confounders, playing with plastic toys is a significant risk factor (β=0.067, P =0.019) for BLL-increment. Plastic toys accounted for the highest proportion (156/294, 53.06%) among the studied toys and had the highest average lead level (39.13 ppm). In the 3 districts where children’s BLLs and toys’ lead levels were both measured, the districts with higher toy lead levels had higher children’s BLLs (the average toy lead levels in Pudong-suburban vs. Xuhui vs. Yangpu supermarkets/ toy-stores: 24.62 vs. 0 vs. 15.43 ppm, P<0.01; the medians of BLLs in Pudong-suburban vs. Xuhui vs. Yangpu children: 2.07 vs. 1.55 vs. 1.50 μg/dL, P<0.001). Lead levels in toys may be associated with the BLLs of young children, and lead contamination in plastic toys need cautions for preventing young children from potential lead exposure.
Structural and Phenotypic Correction of K210del Genetic Cardiomyopathy by an FDA Approved Drug
Authors: Sadek Hesham , Wang Ping , Ahmed Mahmoud , Nguyen Ngoc Uyen Nhi , Menendez-Montes Ivan , Farag Ayman , Thet Suwannee , Hsu Ching-Cheng , Elhelaly Waleed , Lam Nicholas , Wansapura Janaka , MA NIGN , Zhou Shane , Zhang Tiejun , Singh Rohit , Sadayappan Sakthivel , Wu Joseph 
Published: January 2023

Abstract
Dilated cardiomyopathy (DCM), which results from genetic disorders resulting in decreased myocardial contractility, is a leading cause of morbidity and mortality worldwide. There are several therapeutic challenges in treating DCM, which include poor understanding of the underlying mechanism of impaired myocardial contractility, and the difficulty of developing targeted therapies to reverse mutation-specific pathologies. The long, treacherous, and expensive path to new drug development, coupled with the rarity of individual mutations underscore the difficulties of drug development for DCMs. In the current report we focused on K210del, a DCM-causing mutation, which was identified over 20 years ago. This mutation is a three-nucleotide deletion of sarcomeric troponin T (TnnT), resulting in loss of lysine 210. Here we present the crystal structure of the troponin complex carrying the K210del mutation. We found that K210del leads to an allosteric shift in the troponin complex resulting in distortion of activation Ca2+ binding domain of TnnC at S69, thereby resulting in calcium discoordination. Next, we adopted an in-silico approach to identify FDA approved drugs that may correct the structure of the mutant troponin complex, which led us to identify the bisphosphonate risedronate as a potential structural corrector. Co-crystallization of risedronate with the mutant troponin complex restored of the normal configuration of S69 and calcium coordination. At a phenotypic level, risedronate normalized force generation in iPSC-derived cardiomyocytes from a patient carrying the mutation, and restored calcium sensitivity in skinned papillary muscles isolated from K210del mutant mice. Importantly, systemic administration of risedronate to K210del mutant mice normalized left ventricular ejection fraction (LVEF) as determined by echocardiography and MRI. Collectively, these results identify the structural basis for decreased calcium sensitivity in K210del and highlight a path to structural and phenotypic correction as a potential therapeutic strategy in genetic cardiomyopathies.
Treatment effects of two pedicle screws techniques strengthened by bone cement on old patients suffering from osteoporosis and lumbar spinal stenosis
Authors: Pan Wei , Jian Yuekui , He Jinming , Liang Liang 
Published: January 2023

Abstract
OBJECTIVE:To compare treatment effects of pedicle screws techniques strengthened by polymethyl methacrylate (PMMA) bone cement and injectable calcium sulfate cement (CSC) on old patients suffering from osteoporosis and lumbar spinal stenosis.
MATERIALS AND METHODS: One hundred and twenty-four cases are selected and they are divided into PMMA bone cement group with 58 cases and injectable CSC group with
66 cases in order to compare and analyze treatment effects of two groups.
RESULTS: Operation time and total dose of bone cement in CSC group are obviously lower than those in PMMA group and there are no differences regarding bleeding volume between two groups. Visual analog scale in two groups is gradually decreasing. For CSC group, scores at 1 day and 1 week after operation are obviously lower than those in PMMA group and there are no differences regarding this after 1 month. In PMMA group, bone mineral density values are not improved with time while it is increasing gradually in CSC group; differences between groups are of statistical significance (P
< 0.05). Oswestry Disability Indices in two groups after treatment are all decreasing while Japanese Orthopedic Association (JOA) scores are increasing, especially in CSC group, differences are of statistical significance (P < 0.05); effective rate of improvement in CSC group is higher than that in PMMA group, however, as for ranked data, there are no statistical significance. Both groups have good imaging evaluation.
CONCLUSIONS: Injectable CSC has better clinical effects than pedicle screws technique strengthened by PMMA bone cement in terms of treating old patients suffering from osteoporosis and lumbar spinal stenosis.
Genomic-oriented Multi-level Regulatory Landscape of Renal Tumor Metastasis- Related Key Genes
Authors: Zhou Bin , Wang Haiyan , Liu Bo , wang Zhe , zhou Guixia , Zhao Tingting , Du Chunlei , Hu Changdong , Li Xiangping , Ban Bo , Guo Rui 
Published: January 2023

Abstract
Metastasis of renal tumor leads to poor prognosis of patients and increased therapeutic challenges. Nevertheless, the molecular mechanism underlying this clinical phenomenon remain to be elucidated. In this study, we identified 81 metastasis-related key genes and systematically explored their regulatory axis in renal tumor metastasis. In detail, both copy number variation and DNA methylation can partially affect the expressions of these key genes and showed differential distribution in the metastatic group. Path analysis modeling evaluated the potential overall causal effects from genomic level to phenotype and determined five statistical models. Additionally, the competing endogenous network revealed the post-transcriptional regulation of these key genes. Besides that, immune cell infiltration analyses suggested that some key genes may be involve in the regulation of tumor immunologic microenvironment. Furthermore, we built an effective machine learning model to predict renal tumor metastasis for clinical application. In summary, our research systematically described the potential biological roles and regulatory profiles of renal tumor metastasis-related genes, which may contribute to the improvement of clinical targeted therapy for renal tumor.