bluuebunny/crossref_metadata_2025_split huggingface dataset:
Renewable Energy Communities: Enabling Technologies and Regenerative Models for the Green and Digital Transition in the Inner Areas
Authors: Mangano Giuseppe 
Published: May 2023

AbstractThis contribution addresses issues of research in Architectural Technology conducted with the laboratory ABITAlab of dArTe-Unirc, with reference to the design of devices for regenerative models based on the tool of “Renewable Energy Communities” in territories subject to marginalization and depopulation phenomena, such as the inner areas of Grecanica Area in Reggio Calabria. The aim is to envisage a transformative path of sustainable development, which can implement “mechanisms of just and equitable transition” at the local level, placing itself within the lines of support and public investment for climate neutrality, such as the Next Generation EU and the National Plan for Recovery and Resilience in Italy. We investigate the key issues of advanced sustainable project, for the design of devices and integrated innovative tools based on solar technologies (PV) for the production, storage and distribution and sharing of energy by communities settled in the inner areas (prosumers), helping to obtain economic and environmental benefits, towards the “climate neutrality”. The model of Energy Communities, using processes of Advanced Regenerative Design, which increase the performance of the system, thanks to the integration of hybrid “zero impact” technologies, become the tool through which to trigger processes of regeneration and new quality of space and life in the inner territories, where there is a greater presence of natural resources (air, water, sun, biomass, etc.) to be used as renewable sources for energy production, but also the possibility to monitor and more easily account for the impacts of a settlement model based on “carbon free” energy production chains, with the reference community settled.
Transformative Urban Regeneration: Two Paradigmatic Examples in Boston and Paris
Authors: Bevilacqua Carmelina , Sferrazza Miriam 
Published: May 2023

AbstractCities play a fundamental role in the global challenge of climate change, but in most cases financial obstacles and lack of skilled human resources restrain the development of transformative actions. The recovery from Covid-19 pandemics brings a new stimulus for urban sustainable transitions, allocating a large amount of monetary resources for urban regeneration initiatives connected with the SDGs and the Green Deals objectives. Indeed urban regeneration emerges as a key mechanism to address both post-pandemics recovery and climate challenges, facilitating the implementation of urban mitigation and adaptation measures. District-scale projects can become enablers of city-wide sustainable transition, allowing the experimentation of innovative technical solutions to activate multi-systemic transformations. A large literature has been produced over the last 20 years over the topics of Urban Resilience and Sustainable Transition. Nevertheless a multi-sectoral approach to district-scale transformations is just emerging and needs to be integrated through evidences from best practices. This paper aims to identify a portfolio of measures able to transform existing neighborhoods into zero-carbon and climate-resilient systems. With this purpose, two case studies have been explored as paradigmatic examples of sustainable district redevelopment, and namely the Clichy-Batignolles eco-district (Paris) and the Talbot-Norfolk Triangle Eco-Innovation District (Boston).
The importance of flavor in SMEFT Electroweak Precision Fits
Authors: Bellafronte Luigi , Dawson Sally , Giardino Pier Paolo 
Published: May 2023

Abstract
Effective field theory tools are essential for exploring non-Standard Model physics at the LHC in the absence of the discovery of new light particles. Predictions for observables are typically made at the lowest order in the QCD and electroweak expansions in the Standard Model effective field theory (SMEFT) and often ignore the effects of flavor. Here, we present results for electroweak precision observables (EWPOs) at the next-to-leading order QCD and electroweak expansions (NLO) of the SMEFT with an arbitrary flavor structure for the fermion operators. Numerical NLO SMEFT fits to EWPOs have a strong dependence on the assumed flavor structures and we demonstrate this using various popular assumptions for flavor symmetries.
Scattering in black hole backgrounds and higher-spin amplitudes. Part II
Authors: Bautista Yilber Fabian , Guevara Alfredo , Kavanagh Chris , Vines Justin 
Published: May 2023

Abstract
We continue to investigate correspondences between, on the one hand, scattering amplitudes for massive higher-spin particles and gravitons in appropriate quantum-to-classical limits, and on the other hand, classical gravitational interactions of spinning black holes according to general relativity. We first construct an ansatz for a gravitational Compton amplitude, at tree level, constrained only by locality, crossing symmetry, unitarity and consistency with the linearized-Kerr 3-point amplitude, to all orders in the black hole’s spin. We then explore the extent to which a unique classical Compton amplitude can be identified by comparing with the results of the classical process of scattering long-wavelength gravitational waves off an exact Kerr black hole, determined by appropriate solutions of the Teukolsky equation. Up to fourth order in spin, we find complete agreement with a previously conjectured exponential form of the tree-level Compton amplitude. At higher orders, we extract tree-level contributions from the Teukolsky amplitude by an analytic continuation from a physical (a/GM < 1) to a particle-like (a/GM > 1) regime. Up to the sixth order in spin, we identify a unique conservative part of the amplitude which is insensitive both to the choice of boundary conditions at the black hole horizon and to branch choices in the analytic continuation. The remainder of the amplitude is determined modulo an overall sign from a branch choice, with the sign flipping under exchanging purely ingoing and purely outgoing boundary conditions at the horizon. Along the way, we make contact with novel applications of massive spinor-helicity variables pertaining to their relation to EFT operators and (spinning) partial amplitudes.
The Quantization of Proca Fields on Globally Hyperbolic Spacetimes: Hadamard States and Møller Operators
Authors: Moretti Valter , Murro Simone , Volpe Daniele 
Published: May 2023

AbstractThis paper deals with several issues concerning the algebraic quantization of the real Proca field in a globally hyperbolic spacetime and the definition and existence of Hadamard states for that field. In particular, extending previous work, we construct the so-called Møller$$*$$∗-isomorphism between the algebras of Proca observables on paracausally related spacetimes, proving that the pullback of these isomorphisms preserves the Hadamard property of corresponding quasifree states defined on the two spacetimes. Then, we pull back a natural Hadamard state constructed on ultrastatic spacetimes of bounded geometry, along this$$*$$∗-isomorphism, to obtain an Hadamard state on a general globally hyperbolic spacetime. We conclude the paper, by comparing the definition of an Hadamard state, here given in terms of wavefront set, with the one proposed by Fewster and Pfenning, which makes use of a supplementary Klein–Gordon Hadamard form. We establish an (almost) complete equivalence of the two definitions.
A Novel bispecific T-cell engager (BiTE) targeting CD22 and CD3 has both in vitro and in vivo activity and synergizes with blinatumomab in an acute lymphoblastic leukemia (ALL) tumor model
Authors: Meckler Joshua F. , Levis Daniel J. , Vang Daniel P. , Tuscano Joseph M. 
Published: May 2023

AbstractImmunotherapy has revolutionized cancer therapy. Two recently FDA-approved immunotherapies for B-cell malignancies target CD19, in the form of a Bispecific T-Cell Engager (BiTE) antibody construct or chimeric antigen receptor T (CAR-T) cells. Blinatumomab, an FDA-approved BiTE, binds to CD19 on B cells and to CD3 on T cells, mediating effector-target cell contact and T-cell activation that results in effective elimination of target B cells. Although CD19 is expressed by essentially all B-cell malignancies at clinical presentation, relapses with loss or reduction in CD19 surface expression are increasingly recognized as a cause of treatment failure. Therefore, there is a clear need to develop therapeutics for alternate targets. We have developed a novel BiTE consisting of humanized anti-CD22 and anti-CD3 single chain variable fragments. Target binding of the anti-CD22 and anti-CD3 moieties was confirmed by flow cytometry. CD22-BiTE promoted in vitro cell-mediated cytotoxicity in a dose and effector: target (E:T)-dependent fashion. Additionally, in an established acute lymphoblastic leukemia (ALL) xenograft mouse model, CD22-BiTE demonstrated tumor growth inhibition, comparable to blinatumomab. Further, the combination of blinatumomab and CD22-BiTE yielded increased efficacy in vivo when compared to the single agents. In conclusion, we report here the development of a new BiTE with cytotoxic activity against CD22+ cells which could represent an alternate or complementary therapeutic option for B-cell malignancies.
Efficacy, safety, and prognostic factors of PD-1 inhibitors combined with lenvatinib and Gemox chemotherapy as first-line treatment in advanced intrahepatic cholangiocarcinoma: a multicenter real-world study
Authors: Zhu Chengpei , Li Hu , Yang Xiaobo , Wang Shanshan , Wang Yunchao , Zhang Nan , Wang Yanyu , Xue Jingnan , Zhang Longhao , Ning Cong , Yang Xu , Xun Ziyu , Chao Jiashuo , Long Junyu , Sang Xinting , Zhu Zhenyu , Zhao Haitao 
Published: May 2023

Abstract
Background
A programmed cell death protein-1 (PD-1) inhibitor combined with lenvatinib and Gemox chemotherapy as first-line therapy demonstrated high anti-tumor activity against biliary tract cancer in phase II clinical trials. Herein, we aimed to investigate the efficacy and safety for advanced intrahepatic cholangiocarcinoma (ICC) in a multicenter real-world study.

Methods
Patients with advanced ICC who received PD-1 inhibitor combined with lenvatinib and Gemox chemotherapy were retrospectively screened at two medical centers. The primary endpoints were overall survival (OS) and progression-free survival (PFS), whereas the secondary endpoints were objective response rate (ORR), disease control rate (DCR), and safety. Prognostic factors for survival were analyzed.

Results
Fifty-three patients with advanced ICC were included in this study. The median follow-up time was 13.7 (95% confidence interval (CI): 12.9–17.2) months. The median OS and PFS were 14.3 (95% CI: 11.3–NR) and 8.63 (95% CI: 7.17–11.6) months, respectively. The ORR, DCR, and clinical benefit rate were 52.8, 94.3, and 75.5%, respectively. In the multivariate analysis, the tumor burden score (TBS), tumor-node metastasis classification (TNM) stage, and PD-L1 expression were independent prognostic factors for OS and PFS. All patients experienced adverse events (AEs), 41.5% (22/53) experienced grade 3 or 4 AEs, including fatigue (8/53, 15.1%) and myelosuppression (7/53, 13.2%). No grade 5 AEs were reported.

Conclusion
PD-1 inhibitors combined with lenvatinib and Gemox chemotherapy represent an effective and tolerable regimen for advanced ICC in a multicenter retrospective real-world study. TBS, TNM stage, and PD-L1 expression can be used as potential prognostic factors for OS and PFS.
Postoperative Analgesics Score as a Predictor of Chronic Postoperative Inguinal Pain After Inguinal Hernia Repair: Lessons Learned From a Retrospective Analysis
Authors: Widder A. , Reese L. , Lock J. F. , Wiegering A. , Germer C.‐T. , Kindl G.‐K. , Rittner H. L. , Dietz U. , Doerfer J. , Schlegel N. , Meir M. 
Published: May 2023

AbstractBackgroundChronic postoperative inguinal pain (CPIP) is a common complication after inguinal hernia surgery and occurs in up to 10–14% of cases. CPIP has a significant impact on daily life, work ability and thus compromises quality of life. The aim of this retrospective study was an in‐depth analysis of patients undergoing inguinal hernia repair to further refine the prediction of the onset of CPIP reliably.MethodsA single center retrospective analysis of patients with who underwent open or minimally invasive inguinal hernia repair from 2016 to 2021 was carried out. Complication rates, detailed analysis of postoperative pain medication and quality of life using the EuraHS Quality of Life questionnaire were assessed.ResultsOut of 596 consecutive procedures, 344 patients were included in detailed analyses. While patient cohorts were different in terms of age and co‐morbidities, and the prevalence of CPIP was 12.2% without differences between the surgical procedures (Lichtenstein: 12.8%; TEP 10.9%; TAPP 13.5%). Postoperative pain was evaluated using a newly developed analgesic score. Patients who developed CPIP later had a significant higher consumption of analgesics at discharge (p = 0.016). As additional risk factors for CPIP younger patient age and postoperative complications were identified.ConclusionThe prospective use of the analgesic score established here could be helpful to identify patients that are at risk to develop CPIP. These patients could benefit from a structured follow‐up to allow early therapeutic intervention to prevent chronification and restore the quality of life.
The epidemiology of homicide among older adults: retrospective analysis using data from the Victorian Homicide Register
Authors: Kennedy Briohny , Ibrahim Joseph , Koppel Sjaan , Bugeja Lyndal 
Published: May 2023

AbstractOlder adult homicide is unique and under-researched, requiring immediate attention due to the rapidly ageing population. The current study aims to contribute to the description of homicide at the individual, interpersonal, incident and community levels. This research comprised a whole of state jurisdiction population-based retrospective analysis of homicide deaths of older adults aged 65 years and older reported to the Coroner between 2001 and 2015. Descriptive statistical analyses were conducted to compare older adult homicides by sex and the deceased-offender relationship. There were 59 homicide incidents involving 23 female and 36 male deceased (median age=72 years) and 16 female and 41 male offenders (median age=41 years). Individual factors included the following: Deceased frequently had a recorded physical illness (66%), and over one-third were born overseas (37%) or had recent contact with general practitioners and human services (36%). Offenders frequently had a history of illicit drug or alcohol use (63%), diagnosed mental illness (63%) and historical exposure to violence (61%). Interpersonal factors included the following: The deceased-offender relationship tended to be intimate or familial (63%). Incidents factors included the following: incident predominantly occurred in the victim’s home (73%), involving the use of a sharp object (36%), bodily force (31%) or blunt force (20%). The older adult homicide is characterised by poor health in the victim, mental illness, substance abuse or a history of conflict in the either the victim or the offender, familial deceased-offender relationship and the home as the incident location. The results identify future prevention opportunities in clinical and human services settings.
Neuromuscular electrical stimulation during maximal voluntary contraction: a Delphi survey with expert consensus
Authors: Osborne J. O. , Tallent J. , Girard O. , Marshall P. W. , Kidgell D. , Buhmann R. 
Published: May 2023

Abstract
Purpose
The use of electrical stimulation to assess voluntary activation of muscle/s is a popular method employed in numerous exercise science and health research settings. This Delphi study aimed to collate expert opinion and provide recommendations for best practice when using electrical stimulation during maximal voluntary contractions.

Methods
A two-round Delphi study was undertaken with 30 experts who completed a 62-item questionnaire (Round 1) comprising of open- and closed-ended questions. Consensus was assumed if ≥ 70% of experts selected the same response; such questions were removed from the subsequent Round 2 questionnaire. Responses were also removed if they failed to meet a 15% threshold. Open-ended questions were analysed and converted into closed-ended questions for Round 2. It was assumed there was no clear consensus if a question failed to achieve a ≥ 70% response in Round 2.

Results
A total of 16 out of 62 (25.8%) items reached consensus. Experts agreed that electrical stimulation provides a valid assessment of voluntary activation in specific circumstances, such as during maximal contraction, and this stimulation can be applied at either the muscle or the nerve. Experts recommended using doublet stimuli, self-adhesive electrodes, a familiarisation session, real-time visual or verbal feedback during the contraction, a minimum current increase of + 20% to ensure supramaximal stimulation, and manually triggering stimuli.

Conclusion
The results of this Delphi consensus study can help researchers make informed decisions when considering technical parameters when designing studies involving electrical stimulation for the assessment of voluntary activation.
Peripheral blood-based cell signature indicates response to interstitial brachytherapy in primary liver cancer
Authors: Kästle Sophia , Stechele Matthias R. , Richter Lisa , Schinner Regina , Öcal Elif , Alunni-Fabbroni Marianna , De Toni Enrico , Corradini Stefanie , Seidensticker Max , Goldberg S. Nahum , Ricke Jens , Wildgruber Moritz , Kimm Melanie A. 
Published: May 2023

Abstract
Purpose
Biomarkers are essential to implement personalized therapies in cancer treatment options. As primary liver tumors are increasing and treatment is coupled to liver function and activation of systemic cells of the immune system, we investigated blood-based cells for their ability to predict response to local ablative therapy.

Methods
We analyzed peripheral blood cells in 20 patients with primary liver cancer at baseline and following brachytherapy. In addition to platelets, leukocytes, lymphocytes, monocytes, neutrophils and most common ratios PLR, LMR, NMR and NLR, we investigated T cell and NKT cell populations of 11 responders and 9 non-responders using flow cytometry.

Results
We have found a peripheral blood cell signature that differed significantly between responders and non-responders treated with interstitial brachytherapy (IBT). At baseline, non-responders featured higher numbers of platelets, monocytes and neutrophils, a higher platelet-to-lymphocyte ratio and an increase in the NKT cell population with a concurrent reduction in CD16 + NKT cells. Simultaneously, a lower percentage of CD4 + T cells was present in non-responders, as also reflected in a lower CD4/8 ratio. CD45RO + memory cells were lower in both, CD4 + and CD8 + T cell populations whereas PD-1 + T cells were only present in the CD4 + T cell population.

Conclusion
Baseline blood-based cell signature may function as a biomarker to predict response following brachytherapy in primary liver cancer.
Using existing cold stores as thermal energy storage
Authors: Svane Kristian , Enevoldsen Peter , Xydis George 
Published: May 2023

Abstract
The industrial cold stores can act as thermal energy stores that can store the energy as passive thermal energy. The cold stores have intentions to contribute with flexible consumption but need some knowledge about the potential. By cooling the cold stores and the goods further down when the energy is cheaper, there is a potential of an attractive business case, especially if the elspot price can be predicted further into the future. The cold stores can provide flexibility by load shifting to the energy grid by moving their extensive energy use to off-peak hours. To fulfill the potential, it is necessary to measure some data in the cold stores to be able to control them and ensure food safety. A case study was tested and revealed that by cooling further in periods of low-cost electricity could results in 30% savings. With proper elspot price forecasting this percentage could reach up to 40%. Theoretically, by utilizing the full capacity of cold stores in Denmark for thermal energy storage, it is possible to use 2% of the average wind electricity production.
Vortex-Induced Vibration Response Features of A Submarine Multi-Span Pipeline via Towing Tank Experimental Tests
Authors: Xu Wan-hai , Jia Kun , Ma Ye-xuan , Song Zhi-you 
Published: May 2023

AbstractIn offshore engineering, the phenomenon of free span often occurs, and the pipeline may have multiple free spans adjacent to each other, forming a multi-span pipeline. The interaction of different spans makes the structural vibration characteristics more complex, which may change the fatigue characteristics of the pipeline and affect the safety of the structure. In this paper, model tests were designed to explore the vortex-induced vibration (VIV) characteristics of multi-span pipelines and investigate the multi-span interaction mechanism. The experimental study mainly focused on the dynamic response of double-span pipelines, and further extended to triple-span pipelines, hoping that the results can be applied to more complex environment. The effects of span-length ratio, buried depth and axial force on VIV of the pipeline were investigated and discussed. The dynamic response of the pipeline varied with the span length. There was obvious interaction between different spans of multi-span pipelines, and the pipe-sediment interaction obviously affected the vibration characteristics of pipeline. The differences of pipeline burial depth and axial force changed the structural stiffness. With the increase of buried depth, the response amplitude presented a downward trend. The spanwise evolutions were asymmetric caused by the pipe-sediment interaction and multi-span interaction. The results can help to identify multi-span pipelines in engineering, and realize the prevention and control of free spans.
Selection of suitable biomass conservation process techniques: a versatile approach to normal wiggly interval-valued hesitant fuzzy set using multi-criteria decision making
Authors: Narayanamoorthy Samayan , Ramya L. , Gunasekaran Angappa , Kalaiselvan Samayan , Kang Daekook 
Published: May 2023

AbstractA country that relies on developing industrialization and GDP requires a lot of energy. Biomass is emerging as one of the possible renewable energy resources that may be used to generate energy. Through the proper channels, such as chemical, biochemical, and thermochemical processes, it can be turned into electricity. In the context of India, the potential sources of biomass can be broken down into agricultural waste, tanning waste, sewage, vegetable waste, food, meat waste, and liquor waste. Each form of biomass energy so extracted has advantages and downsides, so determining which one is best is crucial to reaping the most benefits. The selection of biomass conversion methods is especially significant since it requires a careful study of multiple factors, which can be aided by fuzzy multi-criteria decision-making (MCDM) models. This paper proposes the normal wiggly interval-valued hesitant fuzzy-based decision-making trial and evaluation laboratory model (DEMATEL) and the Preference Ranking Organization METHod for Enrichment of Evaluations II (PROMETHEE) for assessing the problem of determining a workable biomass production technique. The proposed framework is used to assess the production processes under consideration based on parameters such as fuel cost, technical cost, environmental safety, and $$CO_2$$

C

O
2

emission levels. Bioethanol has been developed as a viable industrial option due to its low carbon footprint and environmental viability. Furthermore, the superiority of the suggested model is demonstrated by comparing the results to other current methodologies. According to comparative study, the suggested framework might be developed to handle complex scenarios with many variables.