bluuebunny/crossref_metadata_2025_split huggingface dataset:
Leishmania (Viannia) naiffi Lainson & Shaw 1989
Authors: Cantanhêde Lilian Motta , Cupolillo Elisa 
Published: June 2023

AbstractJust over 30 years ago, a new species of Leishmania of the subgenus Leishmania (Viannia) was described infecting the armadillo Dasypus novemcinctus; then, a report of human infection followed. From the Brazilian Amazon and apparently restricted to this region and its close borders, Leishmania (Viannia) naiffi has been characterized as a species that grows easily in axenic culture medium and causes few to no lesions after inoculation in experimental animal models. Results in the last decade indicate the occurrence of L. naiffi in vectors and human infections, including a report of therapeutic failure possibly associated with Leishmania RNA virus 1. Overall, such accounts suggest that the parasite is more dispersed and the disease less self-healing than previously expected.
Graphical Abstract
Paravertebral paraganglioma with spinal extension: a case report
Authors: Anavi K. , Daya R. , Daya S. , Purbhoo K. , Profyris C. , Mpanza M. N. , Nel C. E. , Bayat Z. 
Published: June 2023

Abstract
Background
Paragangliomas are rare neuroendocrine tumors. While paragangliomas of the spine are rare, those located in non-cauda equina areas with spinal canal extension are even rarer.

Case presentation
We present a case of a 23-year-old female of African descent with a primary thoracic paraganglioma with intervertebral extension resulting in displacement and compression of the spinal cord and extensive local invasion of the surrounding structures. This paraganglioma was functional with typical symptoms of catecholamine excess. Despite the aggressive nature of the paraganglioma, the patient only had isolated sensory symptoms in the left shoulder. Adequate alpha and beta-blockade were instituted prior to her undergoing surgery with near-total resection and complete preserved neurology. There was no underlying pathogenic genetic mutation found.

Conclusions
Even though rare, paraganglioma should be considered in the differential diagnosis of spinal tumors. Genetic testing should be performed in patients with paragangliomas. One should exercise extreme caution in treating such rare tumors that may cause neurological deficits and careful surgical planning should be undertaken to avoid possible catastrophic complications.
Absence of changes in the milk microbiota during Escherichia coli endotoxin induced experimental bovine mastitis
Authors: Dahlberg Josef , Johnzon Carl-Fredrik , Sun Li , Pejler Gunnar , Östensson Karin , Dicksved Johan 
Published: June 2023

AbstractChanges in the milk microbiota during the course of mastitis are due to the nature of a sporadic occurring disease difficult to study. In this study we experimentally induced mastitis by infusion ofEscherichia coliendotoxins in one udder quarter each of nine healthy lactating dairy cows and assessed the bacteriological dynamics and the milk microbiota at four time points before and eight time points after infusion. As control, saline was infused in one udder quarter each of additionally nine healthy cows that followed the same sampling protocol. The milk microbiota was assessed by sequencing of the 16 S rRNA gene and a range of positive and negative controls were included for methodological evaluation. Two different data filtration models were used to identify and cure data from contaminating taxa. Endotoxin infused quarters responded with transient clinical signs of inflammation and increased SCC while no response was observed in the control cows. In the milk microbiota data no response to inflammation was identified. The data analysis of the milk microbiota was largely hampered by laboratory and reagent contamination. Application of the filtration models caused a marked reduction in data but did not reveal any associations with the inflammatory reaction. Our results indicate that the microbiota in milk from healthy cows is unaffected by inflammation.
Laser treatment for Cafe-au-lait Macules: a systematic review and meta-analysis
Authors: Guo Zi-Zhen , Wang Zhi-Chao , Wang Dun , Ge Ling-Ling , Li Yue-Hua , Gu Yi-Hui , Wang Wei , Wei Cheng-Jiang , Gu Bin , Yao Min , Dong Ji-Ying , Li Qing-Feng 
Published: June 2023

AbstractNowadays, laser is the mainstay treatment for cafe-au-lait macules (CALMs), but no systematic review has been published to demonstrate the overall efficacy and it’s still controversial which type of laser is optimal. Thus, we conduct the meta-analysis to evaluate the effectiveness and side effects of various types of lasers in treating CALMs. Original articles reporting the efficacy and side effects for CALMs in laser treatment were identified in PubMed, EMBASE, and Web of Science from 1983 to April 11, 2023. Using R software and the ‘meta’ package, meta-analysis was conducted for clearance and recurrence for evaluation of efficacy. And the occurrence of hypopigmentation and hyperpigmentation rate was pooled for safety evaluation. We used RoB2 and ROBINS-I tools to assess the risks of bias in RCT studies and non-RCT studies, respectively. The Grading of Recommendations, Assessment, Development and Evaluation system was used to assess the quality of the evidence. Nineteen studies involving 991 patients were included, which had a very low to moderate quality of evidence. The pooled 75% clearance rate was 43.3% (95% CI 31.8–54.7%, I2 = 96%), 50% clearance rate was 75% (95% CI 62.2–85.9%, I2 = 89%) and the recurrence rate was 13% (95% CI 3.2–26.5%, I2 = 88%). The pooled hypopigmentation and hyperpigmentation rates were 1.2% (95% CI 0.3–2.1%, I2 = 0%) and 1.2% (95% CI 0.3–2%, I2 = 0%), respectively. Subgroup analysis revealed that QS-1064-nm Nd:YAG laser treatment not only achieved more than 75% clearance rate in 50.9% of patients (95% CI 26.9–74.4%, I2 = 90%) but also resulted in the lowest hypopigmentation and hyperpigmentation rate of 0.5% (95% CI 0.0–2.5%, I2 = 26%) and 0.4% (95% CI 0.0–2.5%, I2 = 0%). To draw a conclusion, the laser treatment could reach an overall clearance rate of 50% for 75% of the patients with CALMs, for 43.3% of the patients, the clearance rate could reach 75%. When looking at different wavelength subgroups, QS-1064-nm Nd:YAG laser exhibited the best treatment capability. Laser of all the wavelength subgroups presented acceptable safety regarding of the low occurrence of side effects, namely, hypopigmentation and hyperpigmentation.
Risk factors for clinical progression in patients with pulmonary Mycobacterium avium complex disease without culture-positive sputum: a single-center, retrospective study
Authors: Nonaka Mizu , Matsuyama Masashi , Sakai Chio , Matsumura Sosuke , Arai Naoki , Nakajima Masayuki , Saito Takefumi , Hizawa Nobuyuki 
Published: June 2023

Abstract
Objectives
Limited data are available on the progression of pulmonary Mycobacterium avium complex (MAC) disease without culture-positive sputum. The aim of this study was to identify the risk factors associated with clinical progression of pulmonary MAC disease diagnosed by bronchoscopy.

Methods
A single-center, retrospective, observational study was conducted. Pulmonary MAC patients diagnosed by bronchoscopy without culture-positive sputum from January 1, 2013, to December 31, 2017 were analyzed. Clinical progression after diagnosis was defined as having culture-positive sputum at least once or initiation of guideline-based therapy. Then, clinical characteristics were compared between clinically progressed patients and stable patients.

Results
Ninety-three pulmonary MAC patients diagnosed by bronchoscopy were included in the analysis. During the 4-year period after diagnosis, 38 patients (40.9%) started treatment, and 35 patients (37.6%) had new culture-positive sputum. Consequently, 52 patients (55.9%) were classified into the progressed group, and 41 patients (44.1%) were classified into the stable group. There were no significant differences between the progressed and the stable groups in age, body mass index, smoking status, comorbidities, symptoms, or species isolated from bronchoscopy. On multivariate analysis, male sex, monocyte to lymphocyte ratio (MLR) ≥ 0.17, and the presence of combined lesions in the middle (lingula) and lower lobes were risk factors for clinical progression.

Conclusions
Some patients with pulmonary MAC disease without culture-positive sputum progress within 4 years. Therefore, pulmonary MAC patients, especially male patients, having higher MLR or lesions in the middle (lingula) and lower lobes might need careful follow-up for a longer time.
Predictors of current suicidal ideation in a multi-diagnostic sample of individuals with eating disorders
Authors: Izquierdo Alyssa M. , Nelson Jillian D. , Daza Alyssa , Gasbarro Alexandra , Hardin Rebecca , Marino Joanna , Fischer Sarah 
Published: June 2023

Abstract
Background
Individuals with eating disorders (EDs) have high rates of suicidal ideation (SI) and attempts (SA). Fasting, body dissatisfaction, binge eating and purging have been associated with SI in non-clinical samples, individuals with anorexia nervosa or low-weight EDs, and a multi-diagnostic sample. However, few studies have examined how ED symptoms contribute to risk for SI in conjunction with other well-established risk factors, such as nonsuicidal self-injury (NSSI) and past SA. The aim of this study was to examine which ED symptoms contribute unique risk for current SI in a multi-diagnostic, clinical sample when statistically adjusting for gender, NSSI, past SA, and past SI.

Methods
We conducted a chart review of 166 individuals who presented for ED treatment at an outpatient facility and signed informed consent. Initial intake interviews were coded for the presence versus absence of fasting, fear of weight gain, binge eating, purging, excessive exercise, restriction, body checking, self-weighing, and body dissatisfaction, as well as NSSI, past SA, past SI, and current SI.

Results
A total of 26.5% of the sample endorsed current SI. In a logistic regression analysis, identifying as male (n = 17) or having a non-binary gender identity (n = 1), the presence of fasting, and past SI were all significantly associated with increased odds of current SI, whereas excessive exercise significantly decreased odds of current SI. Fasting was equally common across all diagnostic groups.

Conclusions
Future research should establish the temporal relationship between fasting and SI to better inform intervention.
What ethical requirements should be considered in language classroom assessment? insights from high school students
Authors: Azizi Zeinab , Ismail Sayed M. 
Published: June 2023

AbstractThere has been a growing call for listening to test-takers’ voices across diverse assessment contexts. Within classroom assessment (CA), however, test-takers’ voices on ethics are under-researched in the high school context of Iran. Hence, this study purported to disclose Iranian high school test-takers’ (n = 15) perceptions of the ethical requirements in CA. For this purpose, a systematic thematic coding approach (constant-comparative method) was used to analyze the participants’ perceptions. Findings yielded two overarching categories, including do no harm (e.g., establishing a supervision group, considering test-takers’ individual differences, keeping test results confidential, and turning back test sheets with feedback) and avoid score pollution (e.g., using additional knowledge sources, using alternative assessment methods, clarifying grading criteria, avoiding unfamiliar contents and surprise items). The findings refer to a local gloss on global principles of ethics, which is hoped to map out specific dimensions of this important notion for diverse assessment contexts (e.g., high-stakes language testing and CA) and stakeholder groups (e.g., high school teachers, assessment developers, and education officials).
Laboratory experiments on the effects of corrosion inhibitor on the mechanical properties of reservoir rock
Authors: Kortram Jon-Danilo , Barnhoorn Auke , Pluymakers Anne 
Published: June 2023

AbstractGeothermal energy production often involves use of corrosion inhibitors. We performed rock mechanical experiments (room temperature; confining pressure of 10/20/30 MPa) on typical reservoir rocks (Bentheim sandstone and Treuchtlinger limestone) in contact with two different inhibitor solutions or with demineralized water. The sandstone experiments show no discernible difference in rock strength between inhibitors or water, attributed to low quartz reactivity. The limestone experiments show a significant difference in rock strength (and Mohr–Coulomb envelope), dependent on inhibitor type, attributed to high carbonate reactivity. This implies that, depending on the reactivity of the rocks and local stress conditions, inhibitor leakage may lead to unpredicted reservoir failure.
Surgeon anterior cruciate ligament reconstruction volume and rates of concomitant meniscus repair
Authors: Dadoo Sahil , Meredith Sean J. , Keeling Laura E. , Hughes Jonathan D. , Keenan Christopher , Viecelli Mark , Irrgang James J. , Lesniak Bryson P. , Musahl Volker 
Published: June 2023

AbstractPurposeThe purpose of this study was to assess the effect of surgeon anterior cruciate ligament reconstruction (ACLR) volume on rates of ACLR with concomitant meniscus repair versus meniscectomy and subsequent meniscus surgeries.MethodsA retrospective review was conducted from a database of all ACLR performed between 2015 and 2020 at a large integrated health care system. Surgeon volume was categorized as < 35 ACLR per year (low‐volume), and ≥ 35 ACLR per year (high‐volume). Rates of concomitant meniscus repair and meniscectomy were compared between low‐volume and high‐volume surgeons. Subgroup analyses compared the rates of subsequent meniscus surgery and procedure time based on surgeon volume and meniscus procedure type.ResultsA total of 3,911 patients undergoing ACLR were included. High‐volume surgeons performed concomitant meniscus repair statistically significantly more often than low‐volume surgeons (32.0% vs 10.7%, p < 0.001). Binary logistic regression indicated 4.15 times higher odds of meniscus repair among high‐volume surgeons. Subsequent meniscus surgery occurred more commonly following ACLR with meniscus repair among low‐volume surgeons (6.7% vs 3.4%, p = 0.047), but not high‐volume surgeons (7.0% vs 4.3%, p = 0.079). Low‐volume surgeons also had longer procedure times for concomitant meniscus repair (129.9 vs 118.3 min, p = 0.003) and meniscectomy (100.6 vs 95.9 min, p = 0.003).ConclusionsData from this study shows that surgeons with lower volume of ACLR select meniscus resection statistically significantly more often than higher‐volume surgeons. However, an abundance of literature is available to show that meniscus loss negatively affects the development of post‐traumatic osteoarthritis in patients Therefore, as demonstrated in this study by high‐volume surgeons, the meniscus should be repaired and protected whenever possible.Level of EvidenceIII.
Successful living-donor liver transplantation for sustained liver failure even after resolution of infiltrative massive hepatic invasion of stage 4S neuroblastoma: a case report
Authors: Jobara Kanta , Yamamori Ayako , Shizuku Masato , Kurata Nobuhiko , Fujimoto Yasuhiro , Muramatsu Hideki , Takahashi Yoshiyuki , Ogura Yasuhiro 
Published: June 2023

Abstract
Background
Neuroblastoma is the most common extracranial solid tumor in childhood. Stage 4S neuroblastoma is a unique subset of neuroblastoma characterized by a favorable course and potentially low malignancy with a high rate of spontaneous tumor regression. However, recent reports have shown that there is a subgroup of patients with stage 4S neuroblastoma characterized by MYCN amplification, chromosomal aberrations, age of < 2 months at diagnosis, and significantly poorer outcomes.

Case presentation
A 1-month-old male infant with a huge abdominal tumor was transferred to our hospital and diagnosed with stage 4S neuroblastoma. The patient showed respiratory distress due to abdominal compartment syndrome secondary to massive hepatic invasion, and he required a silo operation and mechanical ventilation. After chemotherapy using carboplatin and etoposide, the infiltrative massive hepatic invasion was resolved and the abdominal compartment syndrome gradually improved; however, liver dysfunction as evidenced by hyperbilirubinemia, coagulopathy, and hyperammonemia continued. At the age of 3 months, living-donor liver transplantation was performed for treatment of sustained liver failure using a reduced lateral segment graft from the patient’s father. Post-transplant liver function recovered immediately. Examination of the explanted liver demonstrated that the majority of liver tissue had been replaced by fibroblastic cells after massive hepatocyte dropout. There were only small areas of residual neuroblastoma cells in the liver specimen. The patient was discharged from the hospital 5 months after transplantation with home intermittent respiratory support. At the time of this writing (23 months after liver transplantation), he was in good condition with no signs of recurrence of neuroblastoma.

Conclusions
We have herein presented a case of successful pediatric living-donor liver transplantation for sustained liver failure even after resolution of infiltrative massive hepatic invasion of stage 4S neuroblastoma. Our case clearly shows that liver transplantation can be added as an appropriate extended treatment option for liver failure after resolution of stage 4S neuroblastoma.
Comparative study of different formulae for prediction of best fit endotracheal tube size in children
Authors: Subramani Satheeskumar , Pandey Maitree , Gupta Anshu , Kohli Pramod , Varshney Preeti Goyal 
Published: June 2023

Abstract
Background
Various formulae have been used to predict appropriate endotracheal tube (ETT) size in children, but there is no consensus regarding the best predictor. Recent use of ultrasonography (USG) to predict the ETT size may not always be feasible leaving the physical parameters as most useful and practical option. The present study was planned to compare age-, height- and weight-based formulae for ETT size prediction in children.

Results
The accuracy in predicting ETT size was found to be 88.67%, 73.33% and 32.67% for height-based formula (HBF), age-based formula (ABF) and weight-based formula (WBF), respectively. Pearson correlation coefficient was best for HBF (0.968 with 95% CI of 0.937–0.999), followed by ABF (0.942 with 95% CI of 0.887–0.996) and WBF (0.874 with 95% CI of 0.794–0.953). HBF was found to be best suited for children 1–3 years, ≤ 90 cm and weight < 15 kg with accuracy of > 98%, while WBF was unsatisfactory across all age, height and weight groups.

Conclusions
HBF is the best predictor of ETT size across all age groups with marginal superiority over ABF, especially in age group < 3 years. WBF was least effective in predicting ideal ETT size. It is recommended that HBF should be preferred over ABF and WBF for selection of ETT size in paediatric patients. This practice assumes greater importance especially in emergency situations where exact age and weight cannot be ascertained while height is easily obtainable.
Portal Vein Recanalization–Transjugular Intrahepatic Portosystemic Shunt (PVR-TIPS) with superior mesenteric vein access and balloon-assisted shunt placement
Authors: Dewald Cornelia L. A. , Wacker Frank K. , Maasoumy Benjamin , Hinrichs Jan B. 
Published: June 2023

Abstract
Background
To report the technique and outcome of ultrasound-guided percutaneous access to the superior mesenteric vein (SMV) for balloon-assisted portal vein recanalization–transjugular intrahepatic portosystemic shunt (PVR-TIPS) in a patient with chronic portal venous and splenic vein occlusion.

Case presentation
A 51-year-old, non-cirrhotic patient with severe portal hypertension was admitted for PVR-TIPS. Neither splenic nor hepatic access was feasible due to chronic portal and splenic vein occlusion. Percutaneous ultrasound-guided direct puncture of the SMV was performed to obtain access for balloon-assisted PVR-TIPS. The transmesenteric approach in combination with a balloon puncture technique for PVR-TIPS was successful, and no immediate complications were observed post-procedure. The subsequent follow-up exams showed patent TIPS and SMV without signs of intraabdominal hemorrhage.

Conclusion
Percutaneous ultrasound-guided superior mesenteric vein access for balloon-assisted PVR-TIPS is a feasible option in cases where hepatic or splenic access is not.
Screen time and speech and language delay in children aged 12–48 months in UAE: a case–control study
Authors: Al Hosani Salwa Salem , Darwish Ebtihal Ahmed , Ayanikalath Sona , AlMazroei Ruqaya Saeed , AlMaashari Radwha Saeed , Wedyan Amer Tareq 
Published: June 2023

Abstract
Background
To identify impact of screen time on speech and language development in preschool children. There has been an alarming increase in the use of electronic devices among preschool children despite their potential adverse effects on childhood development during this crucial time of rapid brain development. Prior research has identified the potential risk and benefits of traditional screen media such as television and video. Our findings will help your readers understand the potential impact of screen time between traditional and new technologies. The case–control study included 227 new patients with language delay and 227 normal children, aged 12–48 months male and female. Language delay was diagnosed by reviewing language milestones and Receptive-Expressive Emergent Language Test (RELT). Television viewing variables and child/parental characteristics between both groups were interviewed. Odds ratio was used to establish whether screen time using either electronic devices (smartphones and tablets) or TV viewing has an effect on speech and language development. Chi-square test was used to establish the association between categorical variable 95%. A P-value less than 0.05 was considered to be statistically significant.

Result
A total of 90.3% of those who have speech and language developmental delay use electronic devices. Odd ratio is found to be statistically significant.

Conclusion
The factors that predict language delays include use of and early onset of using an electronic device at 12–24 months of age. The factors that were less likely associated with language delays are watching TV and the mother’s education level.