bluuebunny/crossref_metadata_2025_split huggingface dataset:
Kiritimatiella
Authors: Spring Stefan 
Published: June 2023

Abstract

Ki.ri.ti.ma.ti.el'la. N.L. fem. dim. n.
Kiritimatiella
, pertaining to the Kiritimati Atoll, the geographical origin of the type strain of the type species.

Kiritimatiellota / Kiritimatiellia / Kiritimatiellales / Kiritimatiellaceae / Kiritimatiella

Members of this genus are represented by free‐living, unpigmented, nonmotile, and non‐spore‐forming coccoid cells that divide by binary fission. Intracellular membranes are not formed. Gram‐negative type of cell wall with a peptidoglycan layer. Major cellular fatty acids are iso‐C
14:0
and C
18:0
. Odd‐numbered cellular fatty acids, respiratory lipoquinones, or cytochromes are not detected in significant amounts. The polar lipid composition is dominated by phosphatidylglycerol. Tests for catalase and oxidase are negative. Nitrate is not reduced. Obligately anaerobic, moderately halophilic, mesophilic, and neutrophilic. Strictly fermentative metabolism with sugars as preferred substrates. Yeast extract or vitamins are not required for growth. Members of the class
Kiritimatiellia
, order
Kiritimatiellales
, family
Kiritimatiellaceae
. Known habitats are microbial mats in salt lakes and evaporation ponds.

DNA G + C content (mol%)
: 63 (genome analysis).

Type species
:
Kiritimatiella glycovorans
Spring et al. 2016, VL174.
Miltoncostaeales
Authors: Albuquerque Luciana , Egas Conceição 
Published: June 2023

Abstract

Mil.ton.cos.tae.a'les. N.L. fem. pl. n.
Miltoncostaea
, type genus of the order; L. fem. pl. n. suff. –
ales
, ending to denote an order; N.L. fem. pl. n.
Miltoncostaeales
, the
Miltoncostaea
order.

Actinomycetota / Thermoleophilia / Miltoncostaeales

The order
Miltoncostaeales
is a member of the class
Thermoleophilia
. This order accommodates one family,
Miltoncostaeaceae
, and one genus,
Miltoncostaea
, composed of two validly published species named
Miltoncostaea marina
and
Miltoncostaea oceani
. Cells stain Gram‐negative and form rod‐shaped cells. Endospores are not observed. The members of this order are mesophilic and slightly halophilic. Strictly aerobic and chemoorganotrophic. The peptidoglycan contains
meso
‐diaminopimelic acid (
meso
‐Dpm) as diagnostic diamino acid and is of type A1γ'. The major respiratory quinone is menaquinone 7 (MK‐7). Fatty acids are predominantly straight‐chain; branched fatty acids are also present. Isolated from marine sediments.

DNA G + C content (%)
: 74.8–76.1 (genome).

Type genus
:
Miltoncostaea
Li et al. 2021, VL202.
Kiritimatiellales
Authors: Spring Stefan 
Published: June 2023

Abstract

Ki.ri.ti.ma.ti.el.la'les. N.L. fem. dim. n.
Kiritimatiella
, type genus of the order; L. fem. pl. n. suff. –
ales,
ending to denote an order; N.L. fem. pl. n.
Kiritimatiellales
, the
Kiritimatiella
order.

Kiritimatiellota / Kiritimatiellia / Kiritimatiellales

The order
Kiritimatiellales
as defined in the chapter on the class
Kiritimatiellia
encompasses all cultivated members of the phylum
Kiritimatiellota
, which are represented by the species
Kiritimatiella glycovorans
,
Pontiella desulfatans
,
P. sulfatireligans
, and
Tichowtungia aerotolerans
. Microorganisms assigned to this order are generally free‐living, nonmotile, non‐spore‐forming, coccoid bacteria adapted to anoxic aquatic niches often characterized by marine or hypersaline salinity. Further features common to all strains include cell division by binary fission, a cell wall of the Gram‐negative type that contains peptidoglycan, absence of intracellular membranes, and an anaerobic metabolism based on the fermentation of carbohydrates. Transparent exopolymers are produced by pure cultures of the known strains. A specialization in the degradation of complex polysaccharides can be assumed for most strains, since the corresponding genomes contain a large number of genes encoding glycoside hydrolases and sulfatases. Cellular fatty acid patterns of axenic cultures are dominated by straight‐chain (C
18:0
) and iso‐branched fatty acids (iso‐C
14:0
, iso‐C
18:0
). The major polar lipids were identified as phosphatidylglycerol and diphosphatidylglycerol (cardiolipin). The genome sizes among described representatives of this order range from 2.9 to 8.7 Mb.

DNA G + C content (mol%)
: 53–63 (genome analyses,
n
= 4).

Type genus
:
Kiritimatiella
Spring et al. 2016, VL174.
Application of Conductive MOF in Zinc‐Based Batteries
Authors: Zhang Qian , Jiang Shu , Lv Tingting , Peng Yi , Pang Huan 
Published: June 2023

AbstractThe use of conductive MOFs (c‐MOFs) in zinc‐based batteries has been a popular research direction. Zinc‐based batteries are widely used with the advantages of high specific capacity and safety and stability, but they also face many problems. c‐MOFs have excellent conductivity compared with other primitive MOFs, and therefore have better applications in zinc‐based batteries. In this paper, the transfer mechanisms of the unique charges of c‐MOFs: hop transport and band transport, respectively, are discussed and the way of electron transport is further addressed. Then, the various ways to prepare c‐MOFs are introduced, among which solvothermal, interfacial synthesis, and postprocessing methods are widely used. In addition, the applications of c‐MOFs are discussed in terms of their role and performance in different types of zinc‐based batteries. Finally, the current problems of c‐MOFs and the prospects for their future development are presented.
Förster Resonance Energy Transfer Sensitized Singlet Fission in BODIPY‐Pentacene Dimer Conjugates
Authors: Wollny Anna‐Sophie , Lavarda Giulia , Papadopoulos Ilias , López‐Duarte Ismael , Gotfredsen Henrik , Hou Yuxuan , Tykwinski Rik R. , Torres Tomás , Guldi Dirk M. 
Published: June 2023

AbstractIn the present work, the energy donor 4,4‐difluoro‐4‐bora‐3a,4a‐diaza‐s‐indacene (BODIPY) is used for the first time in combination with a pentacene dimer (Pnc2) to provide the conjugate BODIPYPnc2 that features absorption throughout a large part of the solar spectrum. Upon photoexcitation, the singlet excited state energy of BODIPY is transferred to the pentacene dimer via intramolecular Förster resonance energy transfer (FRET). Subsequently, the pentacene dimer undergoes intramolecular singlet fission. In this process, a singlet correlated triplet pair is generated from the first singlet excited state via coupling to an intermediate state. The results show that solvent polarity has an influence on the system, with the largest FRET rate (i.e., 7.46 × 1011 s−1) being obtained in the most polar solvent (namely, benzonitrile) along with the largest triplet quantum yield (i.e., 207 ± 20%).
Mixing Dion–Jacobson and Ruddlesden–Popper Structures in Quasi‐2D Perovskite Films for Thermal‐ and Photo‐Stable Stimulated Emission
Authors: Jiang Xinyi , Lu Guochao , Wang Xinyang , Wu Xiaohui , Li Jing , Dai Xingliang , Ye Zhizhen , He Haiping 
Published: June 2023

AbstractQuasi‐two–dimensional (2D) perovskite films are promising candidates as a gain medium for stimulated emission owing to their hydrophobicity and efficient energy funneling that facilitates the population inversion. However, the commonly used Ruddlesden–Popper (R–P) perovskites still suffer from instability induced by high‐density pumping as well as the resulting heating effect. Here, quasi‐2D perovskite films with mixed Dion–Jacobson (D–J) and R–P phases are demonstrated with both excellent amplified spontaneous emission (ASE) properties and thermal‐ and photo‐stabilities under ambient conditions. In these films, octyl ammonium bulky organic cations are used to obtain the preferred crystal orientation and highly smooth surface for low‐threshold ASE, while 1,8‐octanedi ammonium cations contribute to the greatly improved stability. The films containing the D–J phase exhibit good structural stability even after 130 °C heat treatment for 48 h. The mixed‐ligands film maintains a low ASE threshold of 11.6 µJ cm−2 and a high optical gain of 413 cm−1 after environmental annealing. It is demonstrated that it is the diammonium that firmly bonds to the perovskite layer,allowing the maintenance of quasi‐2D perovskite structure and good ASE performances.
Frailty after COVID‐19: The wave after?
Authors: König Maximilian , Gollasch Maik , Komleva Yulia 
Published: June 2023

AbstractThe COVID‐19 pandemic poses an ongoing public health challenge, with a focus on older adults. Given the large number of older persons who have recovered from COVID‐19 and reports of long‐lasting sequelae, there is reasonable concern that the COVID‐19 pandemic may lead to a long‐term deterioration in the health of older adults, i.e., a potential “wave of frailty.” Therefore, it is critical to better understand the circumstances surrounding the development of frailty as a result of COVID‐19, as well as the underlying mechanisms and factors contributing to this development. We conducted a narrative review of the most relevant articles published on the association between COVID‐19 and frailty through January 2023. Although few studies to date have addressed the effects of COVID‐19 on the onset and progression of frailty, the available data suggest that there is indeed an increase in frailty in the elderly as a result of COVID‐19. Regarding the underlying mechanisms, a multicausal genesis can be assumed, involving both direct viral effects and indirect effects, particularly from the imposed lockdowns with devastating consequences for the elderly: decreased physical activity, altered diet, sarcopenia, fatigue, social isolation, neurological problems, inflammation, and cardiovascular morbidity are among the possible mediators. Since the COVID‐19 pandemic is leading to an increase in frailty in the elderly, there is an urgent need to raise awareness of this still little‐known problem of potentially great public health importance and to find appropriate prevention and treatment measures.
Effects of methoxy polyethylene glycol‐polycaprolactone block copolymers and silica nanoparticles on the mechanical, tissue affinity and antibacterial properties of n‐butyl cyanoacrylate adhesive
Authors: Su Xiao‐Tong , Jin Guo‐Cheng , Xu Shi‐Ai 
Published: June 2023

AbstractCyanoacrylates are widely used as surgical tissue adhesives because of their high biodegradability, but they are brittle and have poor tissue affinity. In this study, methoxy polyethylene glycol‐polycaprolactone block copolymers (MPEG‐co‐PCLs) with different PCL chain lengths were synthesized by ring‐opening polymerization. Then, a new tissue adhesive with excellent mechanical properties, tissue affinity, antibacterial properties, and coagulation performances was prepared by incorporating MPEG‐co‐PCL and silica nanoparticles (SNPs) into n‐butyl cyanoacrylate (BCA). The optimal MPEG: PCL ratio is 1:4 (MP‐3), and the optimal mass ratio of MPEG‐co‐PCL and SNPs (0.5SNPs/0.5MP‐3) is 0.5 wt.%. Compared to BCA, the adhesion strength and flexibility of 0.5SNPs/0.5MP‐3 are dramatically improved by 110% and 244%, respectively. MPEG‐co‐PCL can fully exploit the advantages of homopolymers, and therefore, improve the tissue affinity and adhesion strength of the adhesive and avoid BCA polymerization initiated by MPEG and poor compatibility of PCL with BCA. SNPs can also compensate for the lack of antibacterial properties of BCA against Gram‐negative bacteria. The E. coli inhibition circle of 0.5SNPs/0.5MP‐3 is twice as large as BCA. SNPs can also improve coagulation by promoting platelet aggregation. This work provides an effective strategy for developing adhesives with potential clinical applications.
Association Study Identified HLA‐DQA1 as a Novel Genetic Risk of Systemic Lupus Erythematosus‐Associated Pulmonary Arterial Hypertension
Authors: Qian Junyan , Chen Ying , Yang Xinzhuang , Wang Qian , Zhao Jiuliang , Deng Xiaoyue , Ding Yufang , Li Shengjie , Liu Yongtai , Tian Zhuang , Shen Juan , Liao Qijun , Wang Yanhong , Zuo Xianbo , Zhang Xuejun , Li Mengtao , Cui Yong , Yu Xueqing , Zeng Xiaofeng 
Published: June 2023

ObjectivePulmonary arterial hypertension (PAH) is a severe complication of systemic lupus erythematosus (SLE). However, the genetic signatures of SLE‐associated PAH have not been well studied. We aimed to identify genetic variants implicated in SLE‐associated PAH susceptibility within the major histocompatibility complex (MHC) region and assess the contribution to clinical outcomes.MethodsA total of 172 patients with SLE‐associated PAH confirmed by right heart catheterization, 1,303 patients with SLE without PAH, and 9,906 healthy controls were included. Deep sequencing of the MHC region was performed to identify alleles, single‐nucleotide polymorphisms, and amino acids. We compared patients with SLE‐associated PAH with patients with SLE without PAH and healthy controls. Clinical association study was conducted to explore the contribution to phenotypes.ResultsA total of 19,881 genetic variants were identified within the MHC region. HLA‐DQA1*03:02 was identified as a novel genetic variant associated with SLE‐associated PAH in the discovery cohort (P = 5.68 × 10−12) and authenticated in an independent replication cohort (P = 1.30 × 10−9). The strongest associated amino acid position was mapped to HLA‐DQα1 in the region affecting MHC/peptide‐CD4+ T cell receptor affinity and antigen binding. Clinical association study demonstrated that patients with SLE‐associated PAH with HLA‐DQA1*03:02 had significantly lower rates of target role achievement (P = 0.005) and survival (P = 0.04).ConclusionThis study, based on the largest cohort of SLE‐associated PAH, is the first to investigate how MHC region genetic variants contribute to SLE‐associated PAH susceptibility. HLA‐DQA1*03:02 is a novel genetic risk factor and a prognostic factor in SLE‐associated PAH. Patients with SLE with this allele require regular monitoring and careful follow‐up for early diagnosis and interventions for potential PAH.
Assessing the impact of 3D image segmentation workshops on anatomical education and image interpretation: A prospective pilot study
Authors: Jinga Maria‐Ruxandra , Lee Rachel B Y , Chan Kai Lok , Marway Prabhvir S. , Nandapalan Krishan , Rhode Kawal , Kui Christopher , Lee Matthew 
Published: June 2023

AbstractThree‐dimensional (3D) segmentation, a process involving digitally marking anatomical structures on cross‐sectional images such as computed tomography (CT), and 3D printing (3DP) are being increasingly utilized in medical education. Exposure to this technology within medical schools and hospitals remains limited in the United Kingdom. M3dicube UK, a national medical student, and junior doctor‐led 3DP interest group piloted a 3D image segmentation workshop to gauge the impact of incorporating 3D segmentation technology on anatomical education. The workshop, piloted with medical students and doctors within the United Kingdom between September 2020 and 2021, introduced participants to 3D segmentation and offered practical experience segmenting anatomical models. Thirty‐three participants were recruited, with 33 pre‐workshop and 24 post‐workshop surveys completed. Two‐tailed t‐tests were used to compare mean scores. From pre‐ to post‐workshop, increases were noted in participants' confidence in interpreting CT scans (2.36 to 3.13, p = 0.010) and interacting with 3D printing technology (2.15 to 3.33, p = 0.00053), perceived utility of creating 3D models to aid image interpretation (4.18 to 4.45, p = 0.0027), improved anatomical understanding (4.2 to 4.7, p = 0.0018), and utility in medical education (4.45 to 4.79, p = 0.077). This pilot study provides early evidence of the utility of exposing medical students and healthcare professionals in the United Kingdom to 3D segmentation as part of their anatomical education, with additional benefit in imaging interpretation ability.
Enhancing High‐Capacity and High‐Rate Sodium‐Ion Storage through Synergistic N,S Dual Doping of Hard Carbon
Authors: Cui Yingxue , Cen Meixiang , Wang Liaoliao , Zhang Yun , Wang Juan , Lian Jiabiao , Li Huaming 
Published: June 2023

AbstractHard carbon, as the most promising commercial anode materials of sodium‐ion batteries (SIBs), has suffered from the coupling limitations on initial Coulombic efficiency (ICE), capacity, and rate capability. Herein, to break such coupling limitations, sulfur‐rich nitrogen‐doped carbon nanomaterials (S‐NC) were synthesized by a synergistic modification strategy, including structure/morphology regulation and dual heteroatom doping. The small specific surface area of S‐NC is beneficial for inhibiting excessive growth of solid electrolyte interphase (SEI) film and irreversible interfacial reaction. The covalent S can serve as active electrochemical sites by Faradaic reactions and provide extra capacity. Benefit by N, S co‐doping, S‐NC shows large interlayer spacing, high defects, good electronic conductivity, strong ion adsorption performance, and fast Na+ ion transport, which combined with a more significant pore volume result in speedier reaction kinetics. Hence, S‐NC possesses a high reversible specific capacity of 464.7 mAh g−1 at 0.1 A g−1 with a high ICE of 50.7%, excellent rate capability (209.8 mAh g−1 at 10.0 A g−1), and superb long‐cycle capability delivering a capacity of 229.0 mAh g−1 (85% retention) after 1800 cycles at 5.0 A g−1.
A protocol for the development of core outcome sets for effectiveness trials and clinical audits in renal cell cancer (R‐COS)
Authors: MacLennan Steven , Wintner Lisa M. , Beyer Katharina , Lawlor Ailbhe , Tripathee Sheela , Dabestani Saeed , Marconi Lorenzo , Giles Rachel H. , Woodward Rose , Van Hemelrijck Mieke , Bex Axel , Zondervan Patricia 
Published: June 2023

AbstractBackgroundThere is inconsistency in outcomes collected in renal cell cancer (RCC) intervention effectiveness studies and variability in their definitions. This makes critical summaries of the evidence base difficult and sub‐optimally informative for clinical practice guidelines and decision‐making by patients and healthcare professionals. A solution is to develop a core outcome set (COS), an agreed minimum set of outcomes to be reported in all trials in a clinical area.ObjectivesTo develop three COS for (a) localised, (b) locally advanced and (c) metastaticRCC study design, participants and methodsThe methods are the same for each of our three COS and are structured in two phases. Phase 1 identifies potentially relevant outcomes by conducting both a systematic literature review and patient interviews (N ~ 30 patients). Qualitative data will be analysed using framework analysis. In phase 2, all outcomes identified in phase 1 will be entered in a modified eDelphi, whereby patients and healthcare professionals (50 of each) will score each outcome's importance (Likert scale from 1 [not important] to 9 [critically important]). Outcomes scored in the 7–9 range by ≥70% and 1–3 by ≤15% will be regarded as ‘consensus in’, and the vice versa of this will constitute ‘consensus out’. All other combinations will be regarded as equivocal and discussed at consensus meetings (including 10 patients and 10 healthcare professionals) in order to vote on them and ratify the results of the eDelphi.DiscussionThe R‐COS will reduce outcome reporting heterogeneity and improve the evidence base for RCC.Study registrationThe study is registered with the COMET initiative: https://www.comet-initiative.org/studies/details/1406.
Pre‐diagnosis lipid levels and mortality after obesity‐related cancer diagnosis in the Women's Health Initiative cardiovascular disease biomarker cohort
Authors: Hovsepyan Gayane , Barac Ana , Brasky Theodore M. , Shadyab Aladdin H. , Lehman Amy , McLaughlin Eric M. , Saquib Nazmus , Iyengar Neil M. , Wild Robert A. , Caan Bette J. , Desai Pinkal , Beebe Dimmer Jennifer , Thomson Cynthia A. , Simon Michael S. 
Published: June 2023

AbstractBackgroundPublished studies have demonstrated inconclusive relationships between serum lipid levels and mortality after cancer.MethodsThe primary objective was to evaluate the relationship between fasting lipid levels and mortality after cancer. Data were obtained on baseline lipids and outcomes after cancer from 1263 postmenopausal women diagnosed with 13 obesity‐related cancers who were part of the Women's Health Initiative (WHI) lipid biomarkers cohort. Obesity‐related cancers included incident invasive cancers of the breast, colorectum, endometrium, esophagus (adenocarcinoma), kidney, liver, gallbladder, pancreas, ovaries, small intestine, thyroid, stomach, as well as multiple myeloma. Baseline lipid measurements included high‐density lipoprotein (HDL)‐cholesterol, low‐density lipoprotein (LDL)‐cholesterol, and non‐HDL‐cholesterol. Outcomes were all cause, cancer‐specific, and CVD mortality. Multivariable Cox proportional hazards models were used to measure associations between lipid levels and mortality (all cause, cancer, and CVD) after a cancer diagnosis, with lipids analyzed as continuous variables.ResultsAmong women with obesity‐related cancer, there were 707 deaths, of which 379 (54%) were due to cancer and 113 (16%) were due to CVD. Mean time from blood draw to cancer diagnosis was 5.1 years (range: 0.05–10 years). LDL‐C values above the 95th percentile were associated with higher risk of all‐cause mortality (p < 0.001), and cancer‐specific mortality (p < 0.001), but not mortality due to CVD. Non‐HDL‐C values above the 65th percentile were associated with higher risk of all‐cause mortality (p = 0.01) and mortality due to CVD (p = 0.003), but not cancer‐specific mortality (p = 0.37). HDL‐C values above the 95th percentile were associated with lower all‐cause mortality (p = 0.002), and above the 65th percentile with lower cancer‐specific mortality (p = 0.003), but no significant relationship with mortality due to CVD was observed.ConclusionsThe relationship between pre‐diagnosis fasting lipid levels and mortality after cancer diagnosis is complex. These results suggest that improved lipid control through lifestyle and anti‐lipid medications could have a meaningful impact on outcomes after cancer.
The PRMT5 inhibitor C9 mitigates hypoxia‐induced carboplatin resistance in lung cancer by inducing autophagy
Authors: Fan Jiangjiang , Li Haichao , Ruan Qiong , Zhu Ximing , Jing Pengyu , Gu Zhongping 
Published: June 2023

AbstractHypoxia, a common feature of solid tumors, can promote chemoresistance in cancer cells. PRMT5 mediates various cellular processes involved in cancer development and progression. However, the role of PRMT5 in hypoxia‐induced chemoresistance is unclear. In this study, hypoxia upregulated PRMT5 expression in lung cancer cells. Additionally, PRMT5 overexpression promoted cancer cell resistance to carboplatin. In carboplatin‐resistant cancer cells, PRMT5 overexpression promoted the methylation of ULK1, a critical regulator of autophagy. ULK1 hypermethylation leads to the upregulation of autophagy, which can improve the survival of cancer cells under hypoxic conditions. Furthermore, this study demonstrated that the PRMT5 inhibitor C9 significantly enhanced the sensitivity of lung cancer cells to carboplatin. These findings suggest that targeting PRMT5‐mediated autophagy with C9 can overcome hypoxia‐induced carboplatin resistance and improve the efficacy of chemotherapy in patients with cancer.