bluuebunny/crossref_metadata_2025_split huggingface dataset:
Highly-sensitive wafer-scale transfer-free graphene MEMS condenser microphones
Authors: Pezone Roberto , Anzinger Sebastian , Baglioni Gabriele , Wasisto Hutomo Suryo , Sarro Lina , Steeneken Peter , Vollebregt Sten 
Published: September 2023

Abstract

Since the performance of micro-electro-mechanical system (MEMS)-based microphones is approaching fundamental physical, design, and material limits, it has become challenging to improve them. Several works have demonstrated graphene’s suitability as a microphone diaphragm. The potential for achieving smaller, more sensitive, and scalable on-chip MEMS microphones is yet to be determined. To address large graphene sizes, graphene-polymer heterostructures have been proposed, but they compromise performance due to added polymer mass and stiffness. This work demonstrates the first wafer-scale integrated MEMS condenser microphones with diameters of 2R = 220 - 320 μm, thickness of 7 nm multi-layer graphene, that is suspended over a backplate with a residual gap of 5 μm. The microphones are manufactured with MEMS
compatible wafer-scale technologies without any transfer steps or polymer layers that are more prone to contaminate and wrinkle the graphene. Different designs, all electrically integrated are fabricated and characterized allowing us to study the effects of the introduction of a back-plate for capacitive read-out. The devices show high mechanical compliances Sm = 0.081 - 1.07 μmPa−1 (10 - 100× higher than the silicon reported in the state-of-the-art diaphragms) and pull-in voltages in the range of 2 – 9.5 V. In addition, to validate the proof of concept, we have electrically characterized the graphene microphone when subjected to sound actuation. An estimated sensitivity of S1kHz = 24.3 - 321 mVPa−1 for a Vbias = 1.5V was determined, which is 1.9 - 25.5× higher than of state-of-the-art microphone devices while having a ∼ 9× smaller area.
Crosstalk between KDEL receptor and EGF receptor mediates cell proliferation and migration via STAT3 signaling Short title: KDELR regulates EGFR-STAT3 signaling
Authors: Jia Jie , Yue Xihua , Tang Shuocheng , Jing Shuaiyang , Zhu Lianhui , Tan Chuanting , Du Yulei , Gao Jingkai , Lee Intaek , Qian Yi 
Published: September 2023

Abstract
Hostile microenvironment of cancer cells provoke a stressful condition for endoplasmic reticulum (ER) and stimulate the expression and secretion of ER chaperones, leading to tumorigenic effects. However, the molecular mechanism underlying these effects is largely unknown. In this study, we reveal that the last four residues of ER chaperones, which are recognized by KDEL receptor (KDELR), is required for cell proliferation and migration induced by secreted chaperones. By combining proximity-based mass spectrometry analysis, split venus imaging and membrane yeast two hybrid assay, we present that EGF receptor (EGFR) may be a co-receptor for KDELR on the surface. Prior to ligand addition, KDELR spontaneously oligomerizes and constantly undergoes recycling near the plasma membrane. Upon KDEL ligand binding, the interactions of KDELR with itself and with EGFR increase rapidly, leading to augmented internalization of KDELR and tyrosine phosphorylation in the C-terminus of EGFR. STAT3, which binds the phosphorylated tyrosine motif on EGFR, is subsequently activated by EGFR and mediates cell growth and migration. Taken together, our results suggest that KDELR serves as a bona fide cell surface receptor for secreted ER chaperones and transactivates EGFR-STAT3 signaling pathway.
Brazilian physicians' attitudes and feelings towards palliative care in pediatrics
Authors: Rocha Anderson , Freitas Lurdiano , Meirelles Bianca , de Assis Lais , Nunes Rui Manuel Lopes 
Published: September 2023

Abstract

Fundamentals:Pediatric palliative care is defined as a care network whose objective is to improve the quality of life of children and adolescents with a disease that threatens the continuity of life and that of their families. In this context, the feelings and attitudes of the team responsible for palliation are evident. To assess and understand the feelings and attitudes of Brazilian physicians regarding the implementation of palliative care in pediatric patients.Methods:Between July 2018 and December 2019, 236 questionnaires were sent to physicians on the National Academy of Palliative Care list. The data collected through the intended questionnaires were analyzed using the programs IRAMUTEQ (Interface de R pour les Analyzes Multidimensionnelles de Textes et de Questionnaires).Results:Based on the analysis performed by IRAMUTEQ, a dendrogram was obtained, containing words with p<0.05. Feelings of sadness, anguish, relief, regret and fulfillment were perceived as relevant. Relevant attitudes, understanding, communication, instructing, dealing well, strategy and multi-professional conferences were described. Thus, it was noticed that these professionals experience different contradictory feelings and make use of different strategies so that they do not harm the treatment performed, in addition to maintaining a good relationship with the patient's family.Conclusion:In the present study, we demonstrate that there are intrinsic characteristics of pediatric palliative care that are a source of mixed feelings for medical professionals. In this context, there are still several feelings, attitudes and challenges. New studies addressing this topic are essential. Attention to these feelings promotes better management of palliative care in pediatrics.
Management of Occupational Injuries and Diseases Compensation Process at Selected Health Facilities in West Rand District, Gauteng Province, South Africa
Authors: Foromo Robert Muraga , Pilusa Mogale Ludwick , Mogotlane Sophie , Paul Yvonne 
Published: September 2023

Abstract

Background: Despite the Compensation for Occupational Injuries and Diseases Act being available at workplace, employees in health facilities still experience challenges on the management process of occupational injury and disease compensation. The Compensation for Occupational Injuries and Diseases Act is meant to compensate employees who acquire occupational injuries and/or diseases at workplace. The study aimed to: (a) describe managers and employee’s knowledge and challenges experienced in the management of occupational injuries and diseases compensation process, at selected health facilities in Gauteng Province and (b) describe recommendations made to enhance the management of occupational injuries and diseases compensation process at workplace.
Methods: The study employed a descriptive, quantitative, and contextual research design. Data were gathered using a self-administered questionnaire on 594 purposively sampled participants. Data were analyzed using the descriptive statistics in Strata version 16.0, at 95% confidence level.
Results: The results of the study revealed that, of the 594 participants, 77% (n=458) lacked knowledge on how to manage occupational injuries and diseases compensation, and 89% (n=529) lacked training in this area. All participants 100% (n=594) reported being unable to use the electronic CompEasy system, which is used to manage occupational injuries and diseases compensation process at workplace.
Conclusion: Recommendations made will assist managers and employees to enhance management of occupational injuries and diseases compensation process. The study results could have significant implications on how managers and employees manage occupational injuries and diseases compensation at workplace.
Macrophage-Derived miR-100-5p Orchestrates Synovial Proliferation and Inflammation in Rheumatoid Arthritis through mTOR Signaling
Authors: Liu Huan , Chen Yuehong , Huang Yupeng , Wei Ling , Ran Jingjing , Li Qianwei , Tian Yunru , Luo Zhongling , Yang Leiyi , Liu Hongjiang , Yin Geng , Xie Qibing 
Published: September 2023

Abstract

Background
Rheumatoid arthritis (RA) is a chronic autoimmune disorder characterized by synovial inflammation, causing substantial disability and reducing life quality. While macrophages are widely appreciated as a master regulator in the inflammatory response of RA, the precise mechanisms underlying the regulation of proliferation and inflammation in RA-derived fibroblast-like synoviocytes (RA-FLS) remain elusive. Here, we provide extensive evidence to demonstrate that macrophage contributes to RA microenvironment remodeling by extracellular vesicles (sEVs) and downstream miR-100-5p/ mammalian target of rapamycin (mTOR) axis.
Results
We showed that cBMDM-sEVs exhibited a notable increase in abundance compared with nBMDM-sEVs. cBMDM-sEVs induced significant RA-FLS proliferation and potent inflammatory responses. Mechanistically, decreased levels of miR-100-5p were detected in cBMDM-sEVs compared with nBMDM-sEVs. miR-100-5p overexpression ameliorated RA-FLS proliferation and inflammation by targeting the mTOR pathway. Partial attenuation of the inflammatory effects induced by cBMDM-sEVs on RA-FLS was achieved through the introduction of an overexpression of miR-100-5p.
Conclusions
Our work reveals the critical role of macrophages in exacerbating RA by facilitating the transfer of miR-100-5p-deficient sEVs to RA-FLS, and sheds light on novel disease mechanisms and provides potential therapeutic targets for RA interventions.
Study on Impact of Gap Difference on Plasma Distribution of Direct Current Vacuum Circuit Breaker with Double-Break
Authors: Huang Chongyang , Yin Yongshuai , Liu Shuxin , Du Hanwen , Shan Zengyu , Cao Yundong 
Published: September 2023

Abstract
During the fault current breaking process of a mechanical direct current vacuum circuit breaker (DC VCB) with double-break (DB), the mechanism's dispersion can result in a gap difference between the two breaks. A DB DC VCB breaking experiment platform is constructed in order to investigate the impact of gap difference on plasma distribution during the DB DC VCB breaking process. During the experiment, a high-speed camera is used to capture the vacuum arcing process at the two breaks under varying gap difference conditions. Then, the arc feature parameters and their variations during the zero zone process are extracted using image processing techniques, and the distribution patterns of plasma and arc energy at the two breaks are analyzed and compared. When there is no gap difference between the two breaks of the experimental DB DC VCB, there are no significant differences in arc energy and the sizes of high, medium, and low-temperature plasma zones between the two breaks. When there is a gap difference between two breaks, the break with the smaller gap has larger high and medium-temperature plasma zones, more concentrated arc energy, higher particle concentration, lower arc diffusion velocity and arc energy decay velocity, and a greater amount of residual plasma after the extinguishing of the arc. When the gap difference exceeds a certain threshold, energy spots appear on the contact surfaces, and a high concentration corridor of residual particles remains between the contacts after the current crosses zero, forming a breakdown weak point that eventually leads to arc re-ignition (hence interruption failure) under the action of transient recovery voltage (TRV).
“Green Synthesis of Sulphur Nanoparticles via Psidium Guajava Leaf Aqueous Extract and Study of their Antimicrobial Activity and Antifungal activity.’’
Authors: Ghodke vrushali Ghodke vrushali , Athare Anil Athare Anil 
Published: September 2023

Abstract
Now a day’s researchers focus on medicinal plant parts which used to synthesize metallic or metal oxide nanoparticles by a green route. This green technique was used for synthesis of sulphur nanoparticles by biologically reducing sodium thiosulphate pentahydrate and citric acid with aqueous leaf extract of Psidium gujava. These synthesized Sulphur nanoparticles are characterized by UV visible Spectrophotometer, Fourier transform infrared spectroscopy, X-ray diffraction, scanning electronic microscopy and high-resolution transmission electron microscopy. The aqueous extract of leaves of Psidium gujava acts as capping and stabilizing agents for the synthesize. These biologically synthesized sulphur nanoparticles were tested for antimicrobial activity against E. coli and Bacillus subtilis bacteria.by Agar well diffusion method and Antifungal activity against Candida albicans by Agar well diffusion method.
An Investigation on the Effect of the Surface Modifications and HNTs loading on the Cure behaviours, Abrasion Resistance, Mechanical and Morphological Properties of NR/EPDM
Authors: S Vishvanathperumal , J Vasanthe Roy , G Anand , K.N. Ramu , S Praveenkumar 
Published: September 2023

Abstract

Research was conducted to investigate the modification of natural halloysite nanotubes (HNTs) using amino silanes, namely (γ-aminopropyl) triethoxysilane (APTES) and Diethoxydimethyl silane (DMS). The impact of these modified HNTs, referred to as APTES-HNTs and DMS-HNTs, on various properties of nanocomposites made from natural rubber (NR) and ethylene-propylene-diene monomer (EPDM) was studied. The properties examined included cure characteristics, tensile properties, hardness, rebound resilience, and compression set qualities of the NR/EPDM nanocomposites. Swelling and cross-link density measurements, abrasion resistance analysis, and fracture morphology examination using FESEM were also performed to validate the experimental outcomes. Utilizing APTES-HNTs as fillers resulted in noteworthy improvements in multiple attributes such as tensile strength, stress at 100% elongation, abrasion resistance, hardness, tear strength, and curing behavior. Notably, the APTES-HNTs filled nanocomposites demonstrated superior resistance to swelling when compared to both HNTs and DMS-HNTs. The enhanced interaction between the filler and rubber matrix, owing to the increased contact surface area, contributed to advancements in mechanical properties and resistance to swelling. Comparing nanocomposites with a base vulcanizate, the incorporation of 10 parts per hundred rubber (phr) APTES-HNTs led to a 36% reduction in abrasion loss. The research findings indicated that the addition of 8 phr APTES-HNTs could potentially increase tensile strength, elongation at break, and stress at 100% elongation by approximately 112%, 31%, and 66%, respectively.
Scaling Performance Frontiers Across Multiple Perioperative Services
Authors: Zhang Erik J. , Saffary Roya , Sharma Soniya , Hagood Joshua M. , Elhajj Andrea J. , Tsai Mitchell H. 
Published: September 2023

Abstract

Background: One of the primary principles governing operating room management includes maximizing clinical efficiency and optimizing the time used in the high-cost, high-revenue environments represented by operating rooms. Under-utilized and over-utilized times are elementary metrics that describe the operating room performance. Performance frontiers visualize the maximal efficiency of systems and their existing constraints.
Methods: Monthly aggregated operating room metrics from services at the University of Vermont Medical Center (UVM), Stanford Hospital, and the University of Alabama (UAB) at Birmingham Hospital were extracted. Paired under- and over-utilized times were plotted against each other. Performance frontiers representing the optimal performance of each service were overlaid.
Results: The Kolmogorov-Smirnov test for goodness-of-fit at 95% level of significance confirms that the performance frontiers representing UVM and Stanford (K-S = 0.9507, p < 0.0001), UVM and UAB (K-S = 0.9989, p < 0.0001), and Stanford and UAB (K-S = 0.9773, p < 0.0001), indicating each service is represented by a different performance frontier.
Conclusions: Our analysis shows that the performance frontier defining the optimal efficiency of UVM is more efficient than that of Stanford and UAB. Differences in efficiency must be due in part to organizational differences between institutions, limited in scale due to the size of institutions; normative statements must be made in relation to the existing organizational structures of each institution and their specific capacity to make changes in tactical decisions. Systemic interventions should be implemented via qualitative analysis of more efficient services, defined by the relative positioning of relevant performance frontiers.
CXCL14 Accelerates Fibroblast Ferroptosis in Inflammatory Bowel Disease by Regulating Lipid Metabolism via SCD1
Authors: HE Zhihua , Lin Lan , Nini Chen , Tingting Li , Chuxiang Huang , Wenxu Pan , Danqiong Liu , Xinhua Liang , Rui Tang , Wenjun Du , Yanling Cheng , Shuzhe Xiao , Yang Cheng , Lanlan Geng , Sitang Gong 
Published: September 2023

Abstract

Inflammatory bowel disease (IBD), historically subdivided into Crohn’s disease and ulcerative colitis, is a chronic, relapsing and heterogeneous condition, resulting in intestinal tissue destruction and dysfunction, such as fibrosis. Currently, there is no effective therapy against colon fibrosis. Fibroblasts are known to contribute to the pathogenesis of IBD-related fibrosis. Recently, our laboratory found that inflammatory fibroblasts in IBD had significantly upregulated Chemokine (C-X-C motif) ligand 14 (CXCL14) expression, suggesting a potential role of CXCL14 in IBD-related fibrosis. Employing Dextran sodium sulfate(DSS)-induced chronic colitis, we showed that CXCL14 was specifically upregulated in collagen-secreting fibroblasts in fibrotic mouse colons. In addition, we showed that CXCL14 was upregulated in human colon fibroblast (HIF and CCD18) culture supernatants induced by transforming growth factor-β1 (TGF-β1), whereas CXCL14 overexpression was sufficient to promote colon fibroblast ferroptosis. Mechanistically, we showed that CXCL14, transcriptionally decreasing the transcript abundance of stearoyl-CoA desaturase-1 (SCD1), mediated its pro-ferroptosis effects by enforcing ERK signaling activity and inhibiting p70 KDa ribosomal protein S6 kinase (S6K) activation in colon fibroblasts. Using a S100 calcium binding protein A4 (S100a4)-cre mice, we generated an intestinal fibroblast-specific CXCL14 knockout mouse line through Adeno-associated virus vectors (AAV) injection into the tail veins. We demonstrated that deletion of CXCL14 in colon fibroblasts accelerated the progression of established colon fibrosis in dextran sodium sulfate (DSS)-induced colitis, suggesting the therapeutic potential of CXCL14 targeting for colon fibrosis and IBD.
The Interplay of Sensory Feedback, Arousal, and Action Tremor Amplitude in Essential Tremor
Authors: Welzel Julius , Güthe Miriam , Keil Julian , Hermann Gesine , Wolke Robin , Maetzler Walter , Becktepe Jos Steffen 
Published: September 2023

Abstract
Essential tremor (ET) amplitude is modulated by visual feedback during target driven movements. In a grip force task, tremor amplitude increased during large scale visual feedback compared to a condition with low scale visual feedback. It has not been examined whether visual feedback exclusively modulates target force tremor amplitude or if other afferent inputs like auditory sensation has a modulatory effect on tremor amplitude as well. Also, it is unknown whether the enhanced sensory feedback causes an increase of arousal in persons with ET (p-ET). We hypothesized that (1) amplitude of tremor is modulated by variation of auditory feedback in the absence of visual feedback in a force tremor paradigm; (2) increase of tremor amplitude coincides with pupillary size as a measure of arousal.
14 p-ET and 14 matched healthy controls (HC) conducted a computer-based experiment in which they were asked to match a target force on a force sensor using their thumb and index finger. The force-induced movement was fed back to the participant visually, auditory or by a combination of both.
Results showed a comparable deviation from the target force (RMSE) during the experiment during all three sensory feedback modalities. The ANOVA revealed an effect of the scaling factor on the tremor severity (Power 4-12Hz) for the visual- and also for the auditory feedback condition in p-ET. Pupillometry showed a significantly increased pupil diameter during the large scale auditory involved feedback conditions compared to the low scale feedback conditions in p-ET. Our findings suggest that action tremor in ET is firstly modulated not only by visual feedback but also by auditory feedback in a comparable manner. Therefore, tremor modulation seems to be modality independent. Secondly, enhanced feedback causes an increase of arousal as measured here by the pupil size. Further work including neurophysiological measures is required to better understand the interaction between arousal and target-related tremor.
Electromyographic Analysis of Elite Para Table Tennis Players with Complete and Incomplete Spinal Cord Injury during Forehand Loop and Backhand
Authors: Norouzi Mehdi , Ardakani Mohammad Karimizadeh , Mahmoudkhani Mohammadreza , Dibafar Majid 
Published: September 2023

Abstract

Background Para table tennis is a popular sport among individuals with disabilities, and each Paralympic sport has its own classification system. This classification aims to minimize the impact of impairments caused by disability on athletic performance. In the present study, the electromyographic variables of the muscles involved in performing the forehand loop and backhand techniques of elite para table tennis players with complete and incomplete spinal cord injuries in the class 5 category were compared. Methods In this study, there were 20 male participants at the national level. According to the ASIA scale, the participants were divided into two groups of 10 people. The first group had complete spinal cord injury, while the second group had incomplete spinal cord injury. After they entered the laboratory, the electrodes were connected to their deltoid, biceps, external oblique, and erector spinae muscles. After connecting the electrodes, the tasks were performed and muscles’ EMG activity, as well as their onset and offset contraction were monitored. Results The findings revealed that there are significant differences in the amount of EMG activity as well as the timing of the onset and offset of contraction of selected muscles in two groups of complete and incomplete spinal cord injuries. Conclusion The findings suggest that athletes with incomplete spinal cord injuries may perform better than those in the complete group. However, current para table tennis classification rules place both groups in the same class, which could impact the outcome of matches.