bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of COVID-19 and effects of booster vaccination with BNT162b2 on six-month long COVID symptoms, quality of life, work productivity and activity impairment during Omicron
Authors: Di Fusco Manuela , Sun Xiaowu , Moran Mary M. , Coetzer Henriette , Zamparo Joann M. , Alvarez Mary B. , Puzniak Laura , Tabak Ying P. , Cappelleri Joseph C. 
Published: July 2023

Abstract
Background
Longitudinal estimates of long COVID burden during Omicron remain limited. This study characterized long-term impacts of COVID-19 and booster vaccination on symptoms, Health-Related Quality of Life (HRQoL), and Work Productivity Activity Impairment (WPAI).

Methods
Outpatients with ≥ 1 self-reported symptom and positive SARS-CoV-2 test at CVS Health United States test sites were recruited between 01/31 and 04/30/2022. Symptoms, EQ-5D and WPAI were collected via online surveys until 6 months following infection. Both observed and model-based estimates were analyzed. Effect sizes based on Cohen’s d quantified the magnitude of outcome changes over time, within and between vaccination groups. Mixed models for repeated measures were conducted for multivariable analyses, adjusting for covariates. Logistic regression assessed odds ratio (OR) of long COVID between vaccination groups.

Results
At long COVID start (Week 4), 328 participants included 87 (27%) Boosted with BNT162b2, 86 (26%) with a BNT162b2 primary series (Primed), and 155 (47%) Unvaccinated. Mean age was 42.0 years, 73.8% were female, 26.5% had ≥ 1 comorbidity, 36.9% prior infection, and 39.6% reported ≥ 3 symptoms (mean: 3.1 symptoms). At Month 6, among 260 participants, Boosted reported a mean of 1.1 symptoms versus 3.4 and 2.8 in Unvaccinated and Primed, respectively (p < 0.001). Boosted had reduced risks of ≥ 3 symptoms versus Unvaccinated (observed: OR 0.22, 95% CI 0.10–0.47, p < 0.001; model-based: OR 0.36, 95% CI 0.15–0.87, p = 0.019) and Primed (observed: OR 0.29, 95% CI 0.13–0.67, p = 0.003; model-based: OR 0.59, 95% CI 0.21–1.65, p = 0.459). Results were consistent using ≥ 2 symptoms. Regarding HRQoL, among those with long COVID, Boosted had higher EQ-5D Utility Index (UI) than Unvaccinated (observed: 0.922 vs. 0.731, p = 0.014; model-based: 0.910 vs. 0.758, p-value = 0.038) and Primed (0.922 vs. 0.648, p = 0.014; model-based: 0.910 vs. 0.708, p-value = 0.008). Observed and model-based estimates for EQ-VAS and UI among Boosted were comparable with pre-COVID since Month 3. Subjects vaccinated generally reported better WPAI scores.

Conclusions
Long COVID negatively impacted HRQoL and WPAI. The BNT162b2 booster could have a beneficial effect in reducing the risk and burden of long COVID. Boosted participants reported fewer and less durable symptoms, which contributed to improve HRQoL and maintain WPAI levels. Limitations included self-reported data and small sample size for WPAI.
Incidental MRI brain findings in children with sensorineural hearing loss
Authors: Alam-Eldeen Mohamad Hasan , Awad Al Hussein , Ameen Hisham Abdelghany 
Published: July 2023

Abstract
Background
Sensorineural hearing loss is one of the leading causes for cognitive dysfunction. Incidental brain abnormalities are frequently seen in patient`s MRI. Our aim was to highlight the incidence of brain abnormalities in children with sensorineural hearing loss and to consider brain screening as a part of the standard cochlear implant MRI protocol.

Methods
This retrospective study included 385 prelingually deaf mute children who were referred for pre-cochlear implant imaging evaluation in the period from January 2020 to June 2022. We evaluated brain images for any structural or white matter abnormality.

Results
We detected brain abnormalities in 62 patients (16.11%), 27 (7.01%) with white matter lesions and 35 patients (9.1%) with other structural brain abnormalities. The commonest white matter lesions were bilateral focal lesions (5.71%). The commonest structural brain abnormality was arachnoid cyst (2.86%). Four patients had two coincidental brain abnormalities. No significant correlation was found between ear abnormalities and white matter lesions or structural brain abnormalities (P > 0.05).

Conclusions
The incidence of brain abnormalities in children with sensorineural hearing loss is not uncommon. Pre-implant MRI screening of the brain helps to obtain best outcomes.
Design, delivery, and evaluation of a knowledge translation intervention for multi-stakeholders
Authors: Randhawa Gurprit Kaur , Orach Juma , Black Agnes , Chan Vivienne , Potter Naomi , Brinkman Jacqui , Côté Hélène , Worfolk Larry , Knight Darryl , Leversage Ivan , Tebbutt Scott J. 
Published: July 2023

Abstract
Background
Knowledge translation (KT) is a key competency for trainees (graduate students and post-doctoral fellows), the new generation of researchers who must learn how to synthesize, disseminate, exchange, and ethically apply knowledge to improve patient and health system services, products, and outcomes. KT training is a key enabler to support KT competency development. Yet, there is a dearth of research on the design, delivery, and evaluation of KT training for trainees.

Methods
The study applied a QUAN(qual) mixed methods approach with an embedded experimental model design. A heart and lung patient was also recruited to participate as a partner and researcher in the study. A multi-faceted KT intervention for trainees was designed, delivered, and evaluated. Data were collected using surveys and focus groups. Quantitative data were analyzed using descriptive and inferential statistics in R Studio and MS Excel. Qualitative data were analyzed in NVivo using thematic analysis.

Results
Participation in each KT intervention varied, with 8–42 participants attending KT webinars, 61 attendees in the Three Minute Thesis (3MT) Competition Heat, and 31 participants in the Patient & Public Forum. In total, 27 trainees and 4 faculty participated in at least one of the KT webinars. Trainee participants reported satisfaction, as well as statistically significant increases in 10/13 KT competencies after receiving one or more components of the KT intervention. Additionally, participating faculty, patients, and the public were satisfied with the intervention components they participated in. Several challenges and facilitators were also identified to improve the KT intervention.

Conclusions
The KT intervention is a promising initiative that can be adopted and adapted across various post-secondary settings to support trainees’ competency development in KT. This evaluation demonstrates that trainees will respond to opportunities for KT training and that capacity for KT competencies can be advanced through a multi-faceted intervention that involves trainees, faculty, patients, and health system collaborators in its design and delivery. This evaluation study contributes the design and results of a novel KT intervention for multi-stakeholders.

Trial registration
N/A.
One musculoskeletal health: towards optimizing musculoskeletal health in Egypt—how to be a bone and muscle builder by the Egyptian Academy of Bone Health and Metabolic Bone Diseases
Authors: El Miedany Yasser , Mahran Safaa , Elwakil Walaa 
Published: July 2023

AbstractBackgroundMusculoskeletal disorders are common problems that affect the elderly. They severely restrict mobility and dexterity, resulting in early retirement from work, lower levels of well-being, and reduced ability to participate in society. With the increase in life expectancy, the older populations are dreaming of active, painless, and independent lives in the face of functional limitations that are the result of various comorbidities with age progression.Main textThe aim of the study is to highlight aging changes in the musculoskeletal system, risk factors that may have a negative impact on musculoskeletal, as well as strategies to optimize musculoskeletal health in the elderly. A narrative review was conducted through a series of literature searches in the database MEDLINE/PubMed focusing on musculoskeletal health. The search terms used were “muscle building,” “bone building,” “osteoporosis,” “osteopenia,” “sarcopenia,” “osteosarcopenia,” “fractures,” “falls,” “functional ability,” “nutrition,” “diet,” “obesity,” “comorbidity,” and “medication.” Data extraction was carried out by the investigators using a standardized data collection form with subsequent discussion among the authors. Peer-reviewed observational controlled and non-controlled studies (case–control and cohort studies) were selected. The data collected in the selected articles were all related to musculoskeletal health.ConclusionMany of the changes in the musculoskeletal system result more from disuse than from simple aging. Less than 10% of the Egyptian population participate in regular exercise, and the most sedentary group is older than 50 years of age. Long-term regular exercises may reduce the loss of bone and muscle mass and prevent age-associated increases in body fat.
Use of ‘acute behavioural disturbance’ in mental health records: differences over time and by ethnicity in a London NHS mental health Trust
Authors: Polling Catherine , Das Preety , Ariyo Kevin , Creary Natalie , Smith Shubulade 
Published: July 2023

Background
Acute behavioural disturbance (ABD) is a controversial descriptor for presentations of severe agitation, aggression and physiological compromise.

Aims
To characterise the use of ABD-related terms in the electronic record of a large UK provider of mental health services during 2006–2021.

Method
The free text of all records relating to patient contacts with acute assessment mental health teams during 2006–2021 were searched for references to ABD. Identified text was coded for context of use and presence of clinical features of ABD described in the literature. Poisson regression was used to analyse differences in rates of use over time and between demographic groups.

Results
Mentions of ABD increased by an average of 1.12 (95% confidence interval (CI), 1.08–1.17) per year, with the greatest increase from 2019 to 2021. Black people were more than twice as likely as White people to have reference to ABD included in their assessments (rate: 2.4/1000 (95% CI 1.8–3.1) in Black people compared with 1.0/1000 (95% CI 0.8–1.3) in White people). The clinical characteristics in notes describing a current presentation of ABD rarely corresponded to those included in UK medical guidelines on ABD.

Conclusions
The term ABD in mental health notes appears to often, but not exclusively, be a synonym for severe agitation and conveys little meaning beyond this. However, the term's connection to a literature emphasising the high risk of physical health collapse and need for urgent treatment means that its disproportionate use in Black people may contribute to existing racial inequalities in the use of coercive measures during crisis presentations.
Barriers and facilitators of community-based implementation of evidence-based interventions in the UK, for children and young people's mental health promotion, prevention and treatment: rapid scoping review
Authors: Thomson Abigail , Harriss Elinor , Peters-Corbett Araminta , Koppel Keili , Creswell Cathy 
Published: July 2023

Background
Community-based organisations continue to take on a greater role in supporting children and young people in the UK with their mental health. However, little evidence exists on the capacity and capability of these settings to effectively implement evidence-based interventions (EBIs).

Aims
To identify barriers and facilitators of the implementation of EBIs within community settings in the UK, for children and young people's mental health promotion, prevention and treatment.

Method
A PRISMA-guided, rapid scoping review was conducted, using predefined criteria and a relevant search strategy on eight databases: Ovid EMBASE, Ovid Medline, Ovid PsycINFO, Ovid Global Health: Scopus, Web of Science All Databases, EBSCO CINAHL and EBSCO ERIC. Study characteristics and data on barriers and facilitators were extracted, with results narratively synthesised.

Results
Five out of 4899 studies met the inclusion criteria, addressing the barriers and facilitators of community-based implementation of EBIs for children and young people's mental health promotion, prevention and treatment. All of the studies that were identified focused on school settings, but we identified no studies that included data on barriers or facilitators of implementing EBIs in other community-based or voluntary sector settings.

Conclusions
There is a lack of available evidence on the capacity and capability of community settings in the UK to effectively implement EBIs and adhere to evidence-based practice. However, existing findings within schools have highlighted key barriers and facilitators to implementation, such as the importance of meaningful involvement of stakeholders throughout the research process, and greater allocation of resources to support evidence-based decision-making in these settings.
Adaptive Cohort Size Determination Method for Bayesian Optimal Interval Phase I/II Design to Shorten Clinical Trial Duration
Authors: Kojima Masahiro 
Published: July 2023

PURPOSE Recently, the strategy for dose optimization in oncology has shifted toward conducting phase II randomized controlled trials with multiple doses. Optimal biologic dose (OBD) selection from phase I trial data to determine candidate doses for phase II trials has been gaining attention. Trials to identify the OBD have a fixed cohort size, which increases the trial duration. We propose a method to increase the cohort size using trial data and shorten the trial duration while maintaining accuracy. METHODS We propose a novel adaptive cohort size determination method in which the increase of cohort size is determined using desirability probability on the basis of toxicity and efficacy data. The desirability probability is a measure of how desirable a dose is and thus how close it is to the OBD. However, during the trial, the desirability probability does not need to be calculated. Instead, the cohort size expansion can be determined by a simple table generated in advance from toxicity and efficacy data. An illustrated example is provided and the performance was evaluated in a simulation study with 16 scenarios. RESULTS In the simulation study, the trial duration was reduced by an average of 20% compared with the conventional design. The percentages of correct OBD selection are almost the same as those with the conventional design. CONCLUSION The proposed adaptive cohort size determination method described in this study reduces trial duration while maintaining accuracy.
Delayed skeletal development and IGF-1 deficiency in a mouse model of lysinuric protein intolerance
Authors: Stroup Bridget M. , Li Xiaohui , Ho Sara , Zhouyao Haonan , Chen Yuqing , Ani Safa , Dawson Brian , Jin Zixue , Marom Ronit , Jiang Ming-Ming , Lorenzo Isabel , Rosen Daniel , Lanza Denise , Aceves Nathalie , Koh Sara , Seavitt John R. , Heaney Jason D. , Lee Brendan , Burrage Lindsay C. 
Published: July 2023

ABSTRACT
SLC7A7 deficiency, or lysinuric protein intolerance (LPI), causes loss of function of the y+LAT1 transporter critical for efflux of arginine, lysine and ornithine in certain cells. LPI is characterized by urea cycle dysfunction, renal disease, immune dysregulation, growth failure, delayed bone age and osteoporosis. We previously reported that Slc7a7 knockout mice (C57BL/6×129/SvEv F2) recapitulate LPI phenotypes, including growth failure. Our main objective in this study was to characterize the skeletal phenotype in these mice. Compared to wild-type littermates, juvenile Slc7a7 knockout mice demonstrated 70% lower body weights, 87% lower plasma IGF-1 concentrations and delayed skeletal development. Because poor survival prevents evaluation of mature knockout mice, we generated a conditional Slc7a7 deletion in mature osteoblasts or mesenchymal cells of the osteo-chondroprogenitor lineage, but no differences in bone architecture were observed. Overall, global Slc7a7 deficiency caused growth failure with low plasma IGF-1 concentrations and delayed skeletal development, but Slc7a7 deficiency in the osteoblastic lineage was not a major contributor to these phenotypes. Future studies utilizing additional tissue-specific Slc7a7 knockout models may help dissect cell-autonomous and non-cell-autonomous mechanisms underlying phenotypes in LPI.
Peruvian contributions to scientific publications on experimental research against COVID-19: a systematic review
Authors: Coronel-Monje Katiusca , Candia-Puma Mayron Antonio , Vilca-Alosilla Juan Jeferson , Goyzueta-Mamani Luis Daniel , Aguilar-Bravo Herbert Mishaelf , Sánchez-Zegarra Jorge Augusto , Barazorda-Ccahuana Haruna Luz , Ferraz Coelho Eduardo Antonio , Chávez-Fumagalli Miguel Angel 
Published: July 2023

Background: One of the countries most adversely affected by the COVID-19 outbreak was Peru. Worldwide scientific knowledge creation has significantly grown because of this pandemic. This systematic study aims to examine several facets of Peru's experimental scientific production concerning COVID-19. Methods: Between December 2019 and June 2022, searches were made in the PubMed database for experimental scientific articles created in Peruvian institutions. Data were extracted and analyzed on the type of biomedical research, the study's applicability, the thematic area and specific thematic, journal impact factor and quartile, funding, grants, and institution of affiliation for the first and correspondence authors. Results: The systematic review resulted in nine studies that met the requirements. The results revealed that Peru needs to promote policies to boost research funding and the number of researchers to produce information that will be useful for managing diseases in the future. Yet, despite the funding provided by national organizations like National Council for Science, Technology, and Technological Innovation (CONCYTEC), there were few publications and little international collaboration. The studies that have been published focus mostly on applied research in the areas of diagnostics, sanitary products, and treatment and transmission, and they have great visibility because they are indexed in Q1 journals. Conclusions: This thorough study revealed Peru's inadequate reaction to COVID-19 regarding experimental scientific research. Peruvian authorities should think about supporting the required policies to boost the number of researchers and financial aid to produce information that may be utilized to manage potential new diseases in the future. Inplasy registration: INPLASY202340080 (23/04/2023).
Social exclusion and its impact on health over the life course: A realist review protocol
Authors: Siersbaek Rikke , O'Donnell Chris , Parker Sarah , Ford John , Burke Sara , Ní Cheallaigh Clíona 
Published: July 2023

Background: Social exclusion is a process whereby certain individuals are born into or pushed to the margins of society and are unable to participate in social, cultural, economic, and political life. People who experience social exclusion are not afforded the same rights and privileges as other population groups. Socially excluded people often experience poorer outcomes in a variety of domains including health, education, employment, and housing than people of a higher social standing. People experiencing social exclusion frequently have higher and more complex health needs and poorer access to healthcare than the general population. The aim of this study is to better understand and explain how social exclusion occurs and how it impacts health over the life course. Methods: A realist review will be undertaken. Data will be collected via a systematic search of peer-reviewed databases and further iterative searches of peer-reviewed and other literatures as needed. The following data bases will be searched: MEDLINE, Embase, CINAHL, and ASSIA, using both indexed subject headings in each database and relevant key words. Grey literature will be searched via Google Scholar and relevant websites of organisations that work with populations affected by social exclusion. Conclusion: A realist review will be conducted to explain the underlying societal mechanisms which produce social exclusion and related health outcomes in particular contexts affecting excluded population groups across the life course. The study has the potential to inform policy makers and service managers of how and why social exclusion occurs and potential key intervention points to prevent exclusion from happening.
Communication strategy of Tourism Departement Yogyakarta in promoting tourism during the COVID-19 pandemic
Authors: Firdaus Nalendra Putra , Anggraeni Sinta , Hariyanti Nunik 
Published: July 2023

Tourism is a sector that is a mainstay for the City of Yogyakarta. The existence of the COVID-19 pandemic has had a significant impact on the Yogyakarta City tourism sector. Department of Tourism of Yogyakarta, a government agency responsible for tourism conditions, should have a strategy to deal with these conditions. This research was conducted to find out how Department of Tourism of Yogyakarta carried out the communication strategy in promoting tourism during the COVID-19 pandemic. The research method used is qualitative with a case study approach, and data collection is carried out using interviews and observations. The results of this study indicate Department of Tourism of Yogyakarta has a strategy for dealing with a pandemic situation by creating a new tagline, "Kangen Jogja". Department of Tourism of Yogyakarta also uses websites and social media to deliver practical information to the public.
Mineralizing agents to manage early carious lesions. Part II: clinical application
Authors: Zhang Jing , Mylonas Petros , Banerjee Avijit 
Published: July 2023

The successful commercialization of mineralization technologies used for the primary and secondary prevention of early carious lesions provides several clinical options for the oral healthcare team using the minimum intervention oral care (MIOC) delivery framework. These new technologies are available in many different forms, with different properties, and can be used in a variety of clinical scenarios. This article is the second in a series providing a review on the clinical efficacy of new technologies and the products available, as well as clinical guidance for their use. CPD/Clinical Relevance: Clinicians should have an appreciation of the different mineralizing agents available, and their related guidelines.
“As Mariposas do Luxo”
Authors: Isabelle Barreto  
Published: July 2023

João do Rio, escritor, percorre as ruas do Rio de Janeiro no início do século XX, observando-a. Este seu comportamento se reflete nas crônicas-reportagens que escreve a partir de suas observações da cidade e, entre aquelas, está “As Mariposas do Luxo”, publicada no livro A Alma Encantadora das Ruas.
Os objetivos do projeto aqui apresentado são resgatar o Rio da primeira década do século XX e aquele livro de João do Rio e utilizar o desenho como ferramenta para difundir o patrimônio iconográfico brasileiro desta época, especialmente as fotos de Augusto Malta e Marc Ferrez.
A metodologia utilizada é a da pesquisa-criação e o fundamento teórico baseia-se nos escritos de Paul Valéry sobre desenho.
Como resultado do projeto obtém-se a webcomic com releitura ilustrada da crônica “As Mariposas do Luxo”, baseada em pesquisa iconográfica sobre o início do século XX no Rio de Janeiro. Cabe ressaltar que esta HQ é parte do projeto de mestrado da autora do artigo.
O material utilizado na pesquisa iconográfica deste projeto é conhecido entre pesquisadores, porém o projeto amplifica o alcance deste material, estabelecendo relação entre o desenho, a fotografia, a literatura e a história da cidade.