bluuebunny/crossref_metadata_2025_split huggingface dataset:
The COVID-19 pandemic and health-related quality of life across 13 high- and low-middle-income countries: A cross-sectional analysis
Authors: Violato Mara , Pollard Jack , Lloyd Andrew , Roope Laurence S. J. , Duch Raymond , Becerra Matias Fuentes , Clarke Philip M. 
Published: April 2023

Background
Most research on the Coronavirus Disease 2019 (COVID-19) health burden has focused on confirmed cases and deaths, rather than consequences for the general population’s health-related quality of life (HRQoL). It is also important to consider HRQoL to better understand the potential multifaceted implications of the COVID-19 pandemic in various international contexts. This study aimed to assess the association between the COVID-19 pandemic and changes in HRQoL in 13 diverse countries.

Methods and findings
Adults (18+ years) were surveyed online (24 November to 17 December 2020) in 13 countries spanning 6 continents. Our cross-sectional study used descriptive and regression-based analyses (age adjusted and stratified by gender) to assess the association between the pandemic and changes in the general population’s HRQoL, measured by the EQ-5D-5L instrument and its domains (mobility, self-care, usual activities, pain/discomfort, and anxiety/depression), and how overall health deterioration was associated with individual-level (socioeconomic, clinical, and experiences of COVID-19) and national-level (pandemic severity, government responsiveness, and effectiveness) factors. We also produced country-level quality-adjusted life years (QALYs) associated to COVID-19 pandemic-related morbidity. We found that overall health deteriorated, on average across countries, for more than one-third of the 15,480 participants, mostly in the anxiety/depression health domain, especially for younger people (<35 years old) and females/other gender. This translated overall into a 0.066 mean “loss” (95% CI: −0.075, −0.057; p-value < 0.001) in the EQ-5D-5L index, representing a reduction of 8% in overall HRQoL. QALYs lost associated with morbidity were 5 to 11 times greater than QALYs lost based on COVID-19 premature mortality. A limitation of the study is that participants were asked to complete the prepandemic health questionnaire retrospectively, meaning responses may be subject to recall bias.

Conclusions
In this study, we observed that the COVID-19 pandemic was associated with a reduction in perceived HRQoL globally, especially with respect to the anxiety/depression health domain and among younger people. The COVID-19 health burden would therefore be substantially underestimated if based only on mortality. HRQoL measures are important to fully capture morbidity from the pandemic in the general population.
Receiving antenatal care components and associated factors in Northwestern Tanzania
Authors: Massenga Joseph , Jeremiah Kidola , Kitinya Wilson , Kim Young-Mi , van Roosmalen Jos , van den Akker Thomas 
Published: April 2023

Introduction
Tanzania had an estimated 5.400 maternal deaths in 2020. Suboptimal quality of antenatal care (ANC) presents a major challenge. It is not known what precisely the uptake of the various ANC components is, such as counseling on birth preparedness and complication readiness, preventive measures and screening tests. We assessed the level of receiving the various ANC components and associated factors in order to identify opportunities to improve ANC.

Methods
A cross-sectional household survey using a structured questionnaire through face-to-face interviews, was conducted in April 2016 in Mara and Kagera regions, Tanzania, applying a two-stage, stratified-cluster sampling design. The analysis included 1,162 women aged 15–49 years who attended ANC during their last pregnancy and had given birth not longer than two years prior to the survey. To account for inter- and intra-cluster variations, we used mixed-effect logistic regression to examine factors associated with receiving essential ANC components: counseling around birth preparedness and complication readiness (with presumed effects on knowledge about danger signs) and preventive measures.

Results
About In 878 (76.1%) women preparedness for birth and its complications was observed to exist. Overall counseling was low where 902 (77.6%) women received adequate counseling. Overall knowledge of danger signs was low in 467 women (40.2%). Uptake of preventive measures was low, with presumptive malaria treatment in 828 (71.3%) and treatment of intestinal worms in 519 (44.7%) women. Screening test levels varied for HIV in 1,057 (91.2%), any blood pressure measurement in 803 (70.4%), syphilis in 367 (32.2%) and tuberculosis in 186 (16.3%) women. After adjusting for age, wealth and parity, the likelihood of receiving adequate counseling on essential topics was less in women without education versus primary education (aOR 0.64; 95% CI 0.42–0.96) and in women who had <4 ANC visits versus ≥4 visits (aOR 0.57; 95% CI 0.40–0.81). Receiving care in privacy or not (aOR 2.01; 95% CI 1.30–3.12) and having secondary education as compared to primary education (aOR 1.92; 95% CI 1.10–3.70) were associated with receiving adequate counseling. Odds of receiving adequate care in at least one ANC visit were lower in women with joint decision making on major purchases versus decision making by male partner or other family members alone (aOR 0.44; 95% CI 0.24–0.78), similar to being less knowledgeable on danger signs (aOR 0.70; 95% CI 0.51–0.96).

Conclusion
Overall uptake of various essential ANC components was low. Frequent ANC visits and ensuring privacy are all essential to improve the uptake of ANC.
No Increased Risk of Cardiac Birth Defects in Infants of Mothers With Celiac Disease: A Population and Sibling Comparison
Authors: Zylberberg Haley M. , Lebwohl Benjamin , Roelstraete Bjorn , Söderling Jonas , Stephansson Olof , Green Peter H.R. , Ludvigsson Jonas F. 
Published: April 2023

INTRODUCTION:Several earlier studies have indicated an increased risk of cardiac birth defects among infants born to mothers with celiac disease (CeD). Through linking nationwide Swedish health care registries, we aimed to investigate maternal CeD and risk of any or cardiac birth defects in their offspring.METHODS:We performed a retrospective cohort study of infants born between 2002 and 2016 to women with biopsy-proven CeD (villous atrophy, Marsh III) matched to infants born to nonceliac women from the general population. Conditional logistic regression with odds ratios (OR) and their 95% confidence intervals (CI) was used to determine the association between maternal CeD and birth defects. To minimize the impact of intrafamilial confounding, we also compared infants born to mothers with CeD with infants born to their nonaffected sisters.RESULTS:A total of 6,990 infants were born to mothers with diagnosed CeD compared with 34,643 infants born to reference mothers. Any birth defect was seen in 234 (33 per 1,000 infants) and 1,244 (36/1,000) reference infants corresponding to an OR of 0.93 (95% CI 0.81–1.08). Cardiac birth defects were seen in 113 (16/1,000) vs 569 (16/1,000) infants (OR 0.98, 95% CI 0.80–1.20). Similar OR for any and cardiac birth defects were also seen in sibling comparisons.DISCUSSION:We found no statistically significant risk of any or cardiac birth defects in infants born to mothers with diagnosed CeD compared with the general population and to their nonaffected sisters.
Study on the nutritional quality and volatile aroma compounds in cupcakes supplemented with raw dehydrated potato flour
Authors: Xu Dan , Chai Yining , Shi Suyuan , Su Xiaodong 
Published: April 2023

Abstract
Cupcakes were made by LZ-111 and LS-10 raw dehydrated potato flour (RDPF) with 10 %, 30 %, and 50 % additions. The addition of RDPFs improved nutritional quality but decreased the height and lightness compared to the control. Supplementation of RDPFs increased the hardness while decreased the adhesiveness and springiness. The sensory evaluation results showed that the score gradually decreased with the increase of RDPFs addition. Thermomechanical properties demonstrated that the gluten strength and the viscosity of the mixed dough were decreased while the water absorption rate was increased. The incorporation of RDPFs revealed a significant increase in volatile aroma compounds and LS-10 contributed more compounds than LZ-111. Isovaleraldehyde (no. 6), hexanal (no. 11) and 1-nonanol (no. 23) were considered to give the highest sensory evaluation scores in odor to the control cupcakes. Tetrachloroethylene (no. 45) and hexafluoro-1,1,3,4-tetrachlorobutane (no. 54) may be the pivotal volatiles caused bad odor in LS-10 RDPF cupcakes.
UBAP2L‐dependent coupling of PLK1 localization and stability during mitosis
Authors: Guerber Lucile , Vuidel Aurore , Liao Yongrong , Kleiss Charlotte , Grandgirard Erwan , Sumara Izabela , Pangou Evanthia 
Published: April 2023

AbstractPLK1 is an important regulator of mitosis whose protein levels and activity fluctuate during the cell cycle. PLK1 dynamically localizes to various mitotic structures to regulate chromosome segregation. However, the signaling pathways linking localized PLK1 activity to its protein stability remain elusive. Here, we identify the Ubiquitin‐Binding Protein 2‐Like (UBAP2L) that controls both the localization and the protein stability of PLK1. We demonstrate that UBAP2L is a spindle‐associated protein whose depletion leads to severe mitotic defects. UBAP2L‐depleted cells are characterized by increased PLK1 protein levels and abnormal PLK1 accumulation in several mitotic structures such as kinetochores, centrosomes and mitotic spindle. UBAP2L‐deficient cells exit mitosis and enter the next interphase in the presence of aberrant PLK1 kinase activity. The C‐terminal domain of UBAP2L mediates its function on PLK1 independently of its role in stress response signaling. Importantly, the mitotic defects of UBAP2L‐depleted cells are largely rescued by chemical inhibition of PLK1. Overall, our data suggest that UBAP2L is required to fine‐tune the ubiquitin‐mediated PLK1 turnover during mitosis as a means to maintain genome fidelity.
Kisi Difraksi dengan Menggunakan Batang Talas (Colocasia esculenta)
Authors: Prabawani Arum , Wahyuni Sri 
Published: April 2023

Eksperimen kisi difraksi sederhana dapat dibuat menggunakan batang talas (Colocasia esculenta) sebagai bahan alami kisi difraksi. Kisi difraksi ini dapat digunakan sebagai alternatif pengganti kisi difraksi standar dalam eksperimen fisika. Kisi difraksi terdiri atas sebaris celah sempit yang saling berdekatan dalam jumlah banyak. Penggunaan kisi difraksi standar dalam eksperimen umumnya hanya terbatas pada penentuan panjang gelombang cahaya tampak. Jika seberkas cahaya koheren dilewatkan kisi difraksi maka akan menghasilkan pola difraksi pada layar. Eksperimen kisi difraksi ini digunakan untuk menentukan besarnya konstanta kisi difraksi ( ) pada batang talas. Kisi difraksi batang talas yang digunakan dalam kondisi fresh yang diambil langsung dari pohonnya. Cahaya koheren dari laser hijau dengan panjang gelombang 532 nm disinarkan tegak lurus melalui batang talas. Dengan variasi jarak kisi ke layar ( ) dihasilkan pola gelap terang pada layar. Pola gelap terang tersebut merupakan fenomena difraksi. Hasil eksperimen didapatkan nilai . Oleh karena itu batang talas dapat digunakan secara mudah dengan harga murah untuk eksperimen kisi difraksi.
PEMBUATAN MEDIA STUDY CARD DAN LEMBAR KERJA SISWA YANG MENGINTEGRASIKAN SOFT SKILLS KONSERVASI BAGI GURU IPA MELALUI KEGIATAN LESSON STUDY
Authors: Sudarmin Sudarmin , Taufiq Muhamad , Parmin Parmin , Annisetyas Regilita 
Published: April 2023

Tujuan pengabdian untuk meningkatkan mutu pembelajaran IPA melalui penerapan media study card dan lembar kerja siswa yang mengintegrasikan soft skills konservasi. Proses pelatihan terhadap guru-guru anggota MGMP IPA SMP/MTs di Kota Semarang telah dilakukan dan mendapatkan respon positif dari guru-guru untuk mendukung pembelajaran yang lebih aktif, efektif dan bermakna. Pada akhir kegiatan pengabdian guru sasaran telah mendapatkan wawasan yang baik tentang pembuatan dan implementasi media study card dan lembar kerja siswa yang mengintegrasikan soft skills konservasi.The goal of the public service is to improve the quality of science teaching through the implementation media study card and student worksheet that integrates conservation soft skills. The process of training of teachers MGMP members IPA SMP / MTs in Semarang has been done and get a positive response from teachers to support learning more active, effective and meaningful. At the end of the service activities targeting teachers have gained a good insight about the creation and implementation of media study cards and worksheets that integrate conservation soft skills.
Pengaruh Jumlah Katalis Stannous Oktoat Pada Pembuatan Poli Asam Laktat dari Limbah Kulit Pisang (Musa Paradisiaca Linn)
Authors: Pebriyanti Dita 
Published: April 2023

Poly lactic acid yang dibuat pada penelitian ini menggunakan asam laktat dari bahan baku limbah kulit pisang kepok. Polimerisasi asam laktat menjadi poli asam laktat dilakukan dengan menggunakan metode ring opening polymerization. Penelitian ini bertujuan untuk mendapatkan konsentrasi katalis dan waktu polimerisasi asam laktat terbaik dalam mendapatkan yield poli asam laktat yang tinggi. Dimana konsentrasi katalis stannous oktoat yang divariasikan adalah 5%, 6% dan 7% dan waktu reaksi 80 menit, 100 menit dan 120 menit. Analisis yang digunakan yaitu analisis gugus fungsi dengan menggunakan Fourier Transform Infra Red Spektroscopy (FTIR), Uji titik leleh dengan Difference Scanning Calorymetry Â dan uji Scanning Electron Microscope. Hasil uji FTIR diperoleh Poly Lactic Acid memiliki gugus â€“OH, hal ini menunjukkanÂ bahwa bahan baku adalah murni atau memiliki pengotor yang sedikit sehingga diperoleh PLA yang memiliki sifat yang sesuai dan tidak jauh berbeda dari standardnya. Untuk uji titik leleh didapatkan nilai transition glass dan transition melting berturut-turut yaitu 60,5oC dan 115,4oC. Jumlah poli asam laktat terbanyak diperoleh dari penambahan katalis 7% dan waktu polimerisasi 120 menit, yakni dengan yieldÂ 47,442%.Kata kunci: Kulit Pisang, Poli Asam Laktat, Polimerisasi Pembukaan Cincin.
How does Pancasila work in countering radicalism and terrorism in Indonesia?
Authors: Ariyani Sri Dewi 
Published: April 2023

Pancasila is a solution to the problems of radicalism that have hit Indonesia today. Then it is hoped that the values in Pancasila must be truly carried out by the Indonesian people to prevent and minimize radicalism and terrorism in our beloved country. The loss of values contained in Pancasila in Indonesian society is the basis of the emergence of various acts of radicalism terrorism in Indonesia. Therefore, the implementation of Pancasila values, in order to remain current in the face of the threat of radicalism must be emphasized in the delivery of the following three messages: 1. This country is formed based on agreement and equality, in which no one should feel as a major shareholder, or first class citizen. 2. Rules for playing in a state have been agreed upon, and the State has full sovereignty to bring order to the members of its country who try systematically to change the order, in ways that are against the law. 3. The state provides protection, opportunity, future and balanced protection to achieve the national goals of a just and prosperous society, prosperous, safe, civilized and free. The Indonesian government recently began to be aware of the development of radicalism in the country related to the ISIS network (the Islamic State of Iraq and Syria). This issue about ISIS has become a global issue and it seems the world is compact to fight it. Seeing this phenomenon, there needs to be steps to prevent acts of radicalism from flourishing on the earth. In addition to taking action on radicalism, the government must also prevent or preventive measures so that people are not easily provoked against ideologies that use religious attributes. Close collaboration between the government, security forces and religious leaders is needed to rectify religious understanding.
La Antigua Casa del Pueblo de Aguilar de la Frontera, un edificio de poder del siglo XX
Authors: Navarro López Francisco 
Published: April 2023

El inmueble de la antigua “Casa del Pueblo” de Aguilar de la Frontera, desempeñó un fuerte papel durante buena parte del siglo XX en la historia local aguilarense, ya que constituyó junto con el Ayuntamiento y el Casino, uno de los tres edificios civiles fundamentales de poder local durante dicha etapa.
Nos encontramos ante un edificio emblemático y de un fuerte valor histórico local, que lamentablemente se perdió para siempre tras su reciente derribo total.
Combined effect of sedentary behavior and physical activity of different intensity on cardiovascular health
Authors: Loginov S. I. 
Published: April 2023

Sedentary behavior (SB) and low (insufficient) physical activity (LPA) are two complementary negative factors affecting cardiovascular health. Most of the current studies are devoted to the study of SB and physical activity (PA) of different intensity separately, while their combined effect has not been studied enough. The purpose was to analyze the literature on the assessment of combined SB+PA effect of different intensity on the general and cardiovascular health of a person. When preparing the review, a search was made for publications in the MedLine, Cochrane, Scopus databases, as well as electronic resources e-library, CyberLeninka and libraries of physical culture and sports universities in Russia for 2002-2022.Issues related to various SB+PA combinations and their effects on general and cardiovascular health are considered and discussed. The facts of the favorable effect of switching sedentary behavior on the same time moderate-intensity PA are presented. The presented data indicate the need for further study, taking into account the mutual substitution of SB and FA of different intensity.
Epicardial obesity and left atrial mechanical dispersion in hypertensive patients with paroxysmal and persistent atrial fibrillation
Authors: Mazur E. S. , Mazur V. V. , Bazhenov N. D. , Nilova O. V. , Nikolaeva T. O. 
Published: April 2023

Aim. To compare the epicardial fat thickness (EFT) in right ventricular anterior wall (RVAW) and left atrial mechanical dispersion (LAMD) in hypertensive (HTN) patients without arrhythmias and with various types of recurrent atrial fibrillation (AF).Material and methods. This observational cross-sectional single-center study included 383 patients with HTN, of which 251 did not have AF, 61 patients had paroxysmal, and 71 patients — persistent AF. Echocardiography performed against the background of sinus rhythm assessed the EFT in RVAW. In addition, using speckle-tracking echocardiography, the LAMD was determined, equal to the percentage of the standard deviation of the time to peak global longitudinal LA strain in the reservoir phase to duration of cardiac cycle.Results. In HTN patients without AF, with paroxysmal and persistent AF, the EFT was 6,70 [5,80; 8,00], 8,20 [7,10; 9,93] and 8,70 [7,93; 10,0] mm (р<0,0001), LAMD — 0,72 [0,58; 0,93], 2,87 [2,40; 3,28] and 2,67 [2,11; 3,15]% (p<0,0001), respectively.Conclusion. In HTN patients with paroxysmal and persistent AF, the EFT in RVAW and LAMD is significantly greater than in patients without arrhythmias. In patients with persistent AF, EFT is greater than in paroxysmal AF, while LAMD practically does not differ.
Primer registro de la estrella quebradiza Hemipholis cordifera (Echinodermata: Ophiuroidea) en Colombia, con algunas notas ecológicas
Authors: Nisperuza-Pérez Carlos , Borrero-Pérez Giomar , Quirós-Rodríguez Jorge , Pineda-Enríquez Tania 
Published: April 2023

Se reporta por primera vez en Colombia la estrella quebradiza Hemipholis cordifera (Bosc,1802) de la familia Ophiactidae. Los especímenes fueron recolectados en aguas poco profundas de la bahía de Cispatá (Córdoba). Se incluye una breve descripción de la especie y anotaciones sobre su ecología y rango de distribución.
A new variety of Chinese radish (loba) Serdtse Podmoskovya for the Central region of Russia
Authors: Stepanov V. A. 
Published: April 2023

The article presents the results of the selection work of the laboratory of breeding and seed production of table root crops of the Federal Scientific Vegetable Center for the culture of Chinese radish (loba). From the collection material (a total of 23 samples were studied), a promising material was selected under the number No. 600 for a complex of economically valuable features. The purpose of the research is to create a variety of Chinese radish – loba for open and protected ground. Based on this goal, the objectives of the research included: to evaluate a promising variety of loba in a nursery of competitive variety testing in open and protected ground conditions, to assess alignment according to the main morphobiological parameters, as well as to assess the safety and resistance to diseases during storage.Results. As a result of repeated individual and family selection in the direction of productivity, resistance to premature stem formation and diseases of vegetation and storage, as well as improvement of taste qualities, a new variety of Chinese radish Serdtse Podmoskovya was bred. The new variety belongs to the pink-red rounded varietal type. The root crop is flat-rounded, large in size. The flesh is white, juicy, with a slightly spicy taste. The variety is medium-ripened, the growing season is 65-75 days, suitable for use in early summer, autumn and winter, resistant to longterm storage (95-96% preservation) and low light. The yield of the variety in protected ground is 2.7 kg/m2, marketability – 88.7%, root crop weight – 533 g; dry matter content – 6.26%, sugars – 2.56%, ascorbic acid – 19.36 mg%. The variety on this background was distinguished by the absence of flowering and diseased plants. The yield in the open ground was 31.2 t/ha (3.12 kg/m2), marketability – 81.2%, root crop weight – 281 g. The variety under these conditions was characterized by a higher content of dry matter –11.0%, sugars – 3.2% and ascorbic acid – 20.13 mg%; a small percentage of flowering (9.4%) and affected plants (6.3%) was noted. For this variety, a technology has been developed for obtaining original and elite seeds according to a one-year development cycle in the conditions of the Central region ща Russia.