bluuebunny/crossref_metadata_2025_split huggingface dataset:
Advances in the Research of Photo, Electrical, and Magnetic Responsive Smart Superhydrophobic Materials: Synthesis and Potential Applications
Authors: Wang Zuoliang , Qu Guangfei , Ren Yuanchuan , Chen Xiuping , Wang Jun , Lu Ping , Cheng Minhua , Chu Xiaomei , Yuan Yongheng 
Published: September 2023

AbstractWith the rapid advancement of technology, the wettability of conventional superhydrophobic materials no longer suffice to meet the demands of practical applications. Intelligent responsive superhydrophobic materials have emerged as a highly sought‐after material in various fields. The exceptional superhydrophobicity, reversible wetting, and intelligently controllable characteristics of these materials have led to extensive applications across industries, including industry, agriculture, defense, and medicine. Therefore, the development of intelligent superhydrophobic materials with superior performance, economic practicality, enhanced sensitivity, and controllability assumes utmost importance in advancing technology worldwide. This article provides a summary of the wettability principles of superhydrophobic surfaces and the mechanisms behind intelligent responsive superhydrophobicity. Furthermore, it reviews and analyzes the recent research progress on light, electric, and magnetic responsive superhydrophobic materials, encompassing aspects such as material synthesis, modification, performance, and responses under diverse external stimuli. The article also explores the challenges associated with different types of responsive superhydrophobic materials and the unique application prospects of light, electric, and magnetic responsive superhydrophobic materials. Additionally, it outlines the future directions for the development of intelligent responsive superhydrophobic materials.
Computational Model for Predicting Particle Fracture During Electrode Calendering
Authors: Xu Jiahui , Paredes‐Goyes Brayan , Su Zeliang , Scheel Mario , Weitkamp Timm , Demortière Arnaud , Franco Alejandro A. 
Published: September 2023

AbstractIn the context of calling for low carbon emissions, lithium‐ion batteries (LIBs) have been widely concerned as a power source for electric vehicles, so the fundamental science behind their manufacturing has attracted much attention in recent years. Calendering is an important step of the LIB electrode manufacturing process, and associated changes in the electrode microstructure and mechanical properties are worthy of study. In this work, we report the observed cracking of active material (AM) particles due to calendering pressure under ex situ X‐ray nano tomography experiments. We developed an innovative 3D discrete element method (DEM) model with bonded connections to physically mimic the calendering process using real AM particle shapes derived from the tomography experiments. The DEM model can well predict the change of the morphology of the dry electrode under pressure, and the changes of the applied pressure and porosity are consistent with the experimental values. At the same time, the model is able to simulate the secondary AM particles cracking by the fracture of the bonds under force. Our model is the first of its kind that can predict the fracture of the secondary particles along the calendering process. This work provides a tool for guidance in the manufacturing of optimized LIB electrodes.
The asymmetric plasma membrane—A composite material combining different functionalities?
Authors: Schütz Gerhard J. , Pabst Georg 
Published: September 2023

AbstractOne persistent puzzle in the life sciences is the asymmetric lipid composition of the cellular plasma membrane: while the exoplasmic leaflet is enriched in lipids carrying predominantly saturated fatty acids, the cytoplasmic leaflet hosts preferentially lipids with (poly‐)unsaturated fatty acids. Given the high energy requirements necessary for cells to maintain this asymmetry, the question naturally arises regarding its inherent benefits. In this paper, we propose asymmetry to represent a potential solution for harmonizing two conflicting requirements for the plasma membrane: first, the need to build a barrier for the uncontrolled influx or efflux of substances; and second, the need to form a fluid and dynamic two‐dimensional substrate for signaling processes. We hence view here the plasma membrane as a composite material, where the exoplasmic leaflet is mainly responsible for the functional integrity of the barrier and the cytoplasmic leaflet for fluidity. We reinforce the validity of the proposed mechanism by presenting quantitative data from the literature, along with multiple examples that bolster our model.
Learning by teaching efficiently enhances learning outcomes in molecular biology of the cell course
Authors: Mijakovic Ivan , Rahimi Shadi 
Published: September 2023

AbstractTo evaluate the impact of active learning approaches in a basic molecular and cell biology course for undergraduate students, we assessed the effect of learning by teaching and peer review on the learning outcomes. A literature seminar activity with peer review and feedback was organized as a compulsory activity for all students, covering about 25% of the course content. The remaining 75% of the course was delivered as classical lectures. The students collaborated in groups to present the content of a review article complemented with a research article. For each group of students, an opponent group was assigned to challenge the presenting group by questions and contribute to the evaluation of the presentation together with the teacher. Based on the feedback survey, the students reacted positively to this active learning exercise, and they strongly recommended keeping it in the future editions of the course. The students' exam scores strongly indicated that the learning outcomes from the learning by teaching part of the course were consistently higher than from the classical lecture part of the course. Further optimization of the active learning part of the course is outlined based on student feedback.
The possibility of mutations of RAS signaling genes and/or TP53 in combination as a negative prognostic impact on pathological stage I non‐small cell lung cancer
Authors: Honda Takayuki , Seto Katsutoshi , Endo Satoshi , Takemoto Akira , Tanimoto Kousuke , Kobayashi Masashi , Kitano Masatake , Sakakibara Rie , Mitsumura Takahiro , Ishibashi Hironori , Inazawa Johji , Tanaka Toshihiro , Miyazaki Yasunari , Okubo Kenichi 
Published: September 2023

AbstractBackgroundThe recurrence rate of non‐small cell lung cancer (NSCLC) is as high as 30%, even in the cancer with pathological stage I disease. Therefore, identifying factors predictive of high‐risk pathological recurrence is important. However, few studies have examined the genetic status of these tumors and its relationship to prognosis.Materials and MethodsA cohort of 328 cases of primary lung cancer that underwent complete resection at Tokyo Medical and Dental University (TMDU) was screened for 440 cancer‐associated genes using panel testing. Further analyses included 92 cases of pathological stage I NSCLC who did not receive adjuvant chemotherapy. Ridge regression was performed to identify association studies mutational status and postoperative recurrence. These data were then validated using clinical and genetic data from 56 patients in The Cancer Genome Atlas (TCGA).ResultsMutations in TP53, RAS signaling genes KRAS and HRAS, and EGFR were recurrently detected. Ridge regression analysis relevant to recurrence, as well as survival analysis, performed using data from the TMDU cohort revealed significantly shorter relapse‐free survival (RFS) for patients with RAS signaling or TP53 gene mutations than for those without (log‐rank test, p = 0.00090). This statistical trend was also suggested in the TCGA cohort (log‐rank test, p = 0.10).ConclusionMutations in RAS signaling genes and/or TP53 could be useful for the prediction of shorter RFS of patients with stage I NSCLC.
Primary groin porocarcinoma in a 43‐year‐old man successfully managed by local excision: A case report and literature review
Authors: Megahed Heba , Al‐Hammadi Ayda , Al‐Nauaimi Noura , Al Hyassat Samir , Al‐Thalathini Mahmoud 
Published: September 2023

AbstractPorocarcinoma is a rare skin malignancy that should be suspected in patients with chronic skin lesions. Although it usually affects the elderly population in sun‐exposed areas, it may be seen in younger populations and in nonexposed areas such as the groin.
G‐CSF‐induced TIPIC syndrome and large vessel vasculitis: A case report
Authors: Arnould Bérangère , Miranda Sébastien , Mignon François , Camus Vincent 
Published: September 2023

Key Clinical MessageWe report a rare adverse event of transient perivascular inflammation of the carotid artery syndrome induced by granulocyte colony‐stimulating factor injections. Recognition of this syndrome is important for physicians, to avoid the exposure of the causative medication, rule out differential diagnosis and delay the use of corticosteroids given the spontaneous improvement after discontinuation of the causative medication.AbstractA 73 year‐old Caucasian woman presented with odynophagia, carotidynia, and fever 5 days following a granulocyte colony‐stimulating factor (G‐CSF) injection for chemotherapy‐induced neutropenia in the setting of myelodysplastic syndrome. Examination showed painful swelling of the neck. Lab results showed inflammation with CRP 328 mg/L. A CT‐scan revealed tissue infiltration thickening surrounding the left internal carotid artery, the carotid bifurcation, and the common carotid artery, as well as circumferential thickening of the aortic arch. Ultrasound of the left internal carotid artery found isoechoic wall thickening. Symptoms drastically improved without steroids in a short time period. Horton's disease, Takayasu's diseases, and infectious vasculitis were not retained due to the short time delay of symptoms onset, atypical echogenicity, and spontaneous improvement. A diagnosis of G‐CSF‐induced large vessel vasculitis transient perivascular inflammation of the carotid artery (TIPIC) syndrome was made. Seven days later, ultrasound control showed diminished thickening infiltration. G‐CSF TIPIC is a rare adverse event that should be kept in mind in patients under G‐CSF.
Low T3 syndrome predicts more adverse events in patients with hypertrophic cardiomyopathy
Authors: He Chao‐Jie , Zhu Chun‐Yan , Fan Hong‐Yan , Qian Ye‐Zhou , Zhai Chang‐Lin , Hu Hui‐Lin 
Published: September 2023

AbstractBackgroundHypertrophic cardiomyopathy (HCM) is a common cardiac genetic disorder that clinically manifests with sudden death and progressive heart failure. Moreover, thyroid dysfunction is associated with increased cardiovascular morbidity and mortality risks. Therefore, this study aimed to clarify whether thyroid hormones could serve as an independent predictor of adverse events in patients with HCM.MethodsThe cohort consisted of 782 patients with HCM who had thyroid hormones baseline data and were admitted to the Affiliated Hospital of Jiaxing University. Patients were divided into two groups according to serum levels of free triiodothyronine (fT3): the normal fT3 and low triiodothyronine (T3) syndrome groups. Low T3 syndrome was defined as fT3 < 2.43 pmol/L with a normal thyroid‐stimulating hormone (TSH) level. Patients whose TSH levels were abnormally high or abnormally low were excluded from this study. The primary endpoint was the occurrence of sudden cardiac death (SCD) events, and the secondary endpoint was a composite of worsening heart failure (WHF) events, including heart failure death, cardiac decompensation, hospitalization for heart failure, and HCM‐related stroke. The Kaplan–Meier and Cox regression were performed for the survival analysis.ResultsAfter a median follow‐up of 52 months, 75 SCD events and 134 WHF events were recorded. The Kaplan–Meier survival curves showed that the cumulative incidence of SCD events and WHF events were significantly higher in patients with low T3 syndrome (log‐rank p = .02 and log‐rank p = .001, respectively). Furthermore, multivariate Cox regression analysis demonstrated that low T3 syndrome is a strong predictor of SCD events and WHF events (adjusted hazard ratio [HR: 1.53, 95% confidence interval [CI]: 1.13–2.24, p < .01; HR: 3.87, 95% CI: 2.91–4.98, p < .001, respectively).ConclusionsLow T3 syndrome is highly prevalent among patients with HCM and was independently associated with an increased risk of SCD events and WHF events. The routine assessment of serum fT3 levels may provide risk stratification in this population.
Inherently disordered regions of axonemal dynein assembly factors
Authors: King Stephen M. 
Published: September 2023

AbstractThe dynein‐driven beating of cilia is required to move individual cells and to generate fluid flow across surfaces and within cavities. These motor enzymes are highly complex and can contain upwards of 20 different protein components with a total mass approaching 2 MDa. The dynein heavy chains are enormous proteins consisting of ~4500 residues and ribosomes take approximately 15 min to synthesize one. Studies in a broad array of organisms ranging from the green alga Chlamydomonas to humans has identified 19 cytosolic factors (DNAAFs) that are needed to specifically build axonemal dyneins; defects in many of these proteins lead to primary ciliary dyskinesia in mammals which can result in infertility, severe bronchial problems, and situs inversus. How all these factors cooperate in a spatially and temporally regulated manner to promote dynein assembly in cytoplasm remains very uncertain. These DNAAFs contain a variety of well‐folded domains many of which provide protein interaction surfaces. However, many also exhibit large regions that are predicted to be inherently disordered. Here I discuss the nature of these unstructured segments, their predicted propensity for driving protein phase separation, and their potential for adopting more defined conformations during the dynein assembly process.
Electrostatic Self Assembly of Metal‐Free Hexagonal Boron Nitride/Protonated Carbon Nitride (h‐BN/PCN) Nanohybrid: A Synergistically Upgraded 2D/2D Sustainable Electrocatalyst for Sulfamethazine Identification
Authors: Govindaraj Muthukumar , P K Udhaya Ganesh , Muthukumaran Magesh Kumar , Sekar Karthikeyan , Maruthapillai Arthanareeswari , Arockia Selvi J. 
Published: September 2023

AbstractIn the scientific community, developing a non‐enzymatic detection tool for highly reliable and sensitive identification of the targeted biomolecules is challenging. Sulfamethazine (SMZ), a bacterial inhibitor frequently used as an antibacterial medicine, can cause antimicrobial resistance (AMR) in humans if taken in excess. Hence, there is a need for a reliable and rapid sensor that can detect SMZ in food and aquatic environments. The goal of this study aims to develop a novel, inexpensive 2D/2D hexagonal boron nitride/protonated carbon nitride (h‐BN/PCN) nanohybrid that can function as an electrocatalyst for SMZ sensing. The as‐synthesized material‘s crystalline, structural, chemical, and self‐assembly properties were thoroughly characterized by XRD, HR‐TEM, XPS, HR‐SEM, FT‐IR, and ZETA potential and electrochemical sensing capacity of the suggested electrodes was optimized using CV, EIS, DPV, and i‐t curve techniques. The above nanohybrid of h‐BN/PCN‐modified GCE exhibits improved non‐enzymatic sulfamethazine sensing behaviour, with a response time of less than 1.83 s, a sensitivity of 1.80 μA μM−1 cm−2, a detection limit of 0.00298 μM, and a range of 10 nM to 200 μM. The electrochemical analysis proves that the conductivity of h‐BN has significantly improved after assembling PCN due to the large surface area with active surface sites and the synergistic effect. Notably, our constructed sensor demonstrated outstanding selectivity over a range of probable interferents, and electrochemical studies indicate that the suggested sensor has improved functional durability, rapid response, impartial repeatability, and reproducibility. Furthermore, the feasibility of an h‐BN/PCN‐modified sensor to detect the presence of SMZ in food samples consumed by humans has been successfully tested with high recovery percentages.
Unveiling the Noncovalent Interaction of Thiazol‐2‐ylidene and Its Derivatives as N‐heterocyclic Carbene with Different Proton Donor Molecules
Authors: Keot Niharika , Lama Bittu , Singh Haobam Kisan , Bhattacharyya Himangshu Pratim , Sarma Manabendra 
Published: September 2023

AbstractThe importance of noncovalent interaction has gained attention in various domains covering drug and novel catalyst design. The present study mainly characterizes the role of hydrogen bond (H‐bond) and other intermolecular interactions in different (1 : 1) complex analogues formed between the N‐aryl‐thiazol‐2‐ylidene (YR) and five proton donor (HX) molecules. The analysis of the singlet‐triplet energy gap (
) confirmed the stability of the singlet state for this class of N‐aryl‐thiazol‐2‐ylidenes than the triplet state. The interaction energy values of the YR‐HX complexes follow the order: YR‐NH3<YR‐HCN<YR‐H2O<YR‐MeOH<YR‐HF. In addition, substituting the H‐atom of the N−H bond with bulky groups (−R) leads to an increase in the interaction energy of the YR‐HX complexes. Hence, it was found that the replacement of N‐atom in N‐heterocyclic carbene (NHC) by S‐atom forming N‐aryl‐thiazol‐2‐ylidene results in comparable intermolecular interactions with proton donor molecules similar to imidazole‐2‐ylidene (NHC). The current study enlightened the role of noncovalent interactions in carbene complexes with proton donor molecules. We hope that our work on carbene chemistry will pave the way for its application in the designing and synthesis of efficient catalysts.
Reversible Acid‐Base Responsive Fluorescence Changes of Solutions and Crystals Based on Anthracenyl Pyridyl Derivatives
Authors: Zhang Tian‐Le , Zhao Chengxi , Liu Zhi‐Jian , Xu Tian‐Yi , Lin Hui‐Yao , Zhou Shang‐Wu , Li Yu‐Hao , Tong Fei 
Published: September 2023

AbstractOrganic compounds that can respond to external stimuli and exhibit fluorescence changes have drawn increasing attention recently because of their potential applications in intelligent displays, optical data storage, anticounterfeiting, bioimaging, and sensors. Herein, we have synthesized two new organic compounds based on frameworks of anthracene and pyridine groups: 4‐(anthracen‐9‐yl) pyridine (AN9P) and 4‐(anthracen‐2‐yl) pyridine (AN2P). Both compounds, in solution and solid state, including polycrystals and single crystals, display reversible fluorescence transformations under alternate acid and base treatments. AN9P and AN2P solutions could be regulated to emit white‐light luminescence. The photoluminescence of the AN9P and AN2P polycrystals showed fast fluorescence changes with wide ranges (>300 nm) upon alternate acid and base stimuli and still exhibited remarkable fluorescence emission with almost no attenuation after 15 cycles of the reversible process. Both experimental and computational results suggested that the heteroatom nitrogen in the AN9P and AN2P molecules significantly influenced the intra‐ and intermolecular electronic interactions during the reversible protonation and deprotonation processes, resulting in changes in their frontier molecular orbitals and fluorescence emission characteristics. Our results provide a new facile approach to design molecular structures that realize highly dynamic photoluminescence changes in both liquid solution and solid crystal.
Structural Diversity in Cyclometalated Diiridium(III) Complexes with Bridging syn and anti μ2‐Oxamidato and μ2‐Dithioxamidato Ligands
Authors: M'hamedi Ahmed , Batsanov Andrei S. , Fox Mark A. , Aguilar Juan A. , Bryce Martin R. 
Published: September 2023

AbstractSix new diiridium complexes containing 2‐methyl‐6‐phenylpyridyl as the cyclometalating ligand with a μ2‐oxamidato or a μ2‐dithioxamidato ligand as the bridge have been synthesized in 60–73 % yields. These complexes were revealed by multinuclear NMR spectroscopy to contain inseparable mixtures of diastereomers (rac, ΔΔ/ΛΛ and meso, ΔΛ) with bridges in anti and syn configurations. The remarkable variety of isomers present was confirmed by X‐ray crystallography on single crystals grown from mixtures of each complex. In one complex with a N,N’‐bis(4‐trifluoromethylphenyl)‐μ2‐oxamidato bridge, two single crystals of anti and syn isomers were structurally determined. Two single crystals of the μ2‐dithioxamidato bridge complex were found to contain rac and meso forms of the syn isomer. Hybrid DFT computations on the four isomers of each diiridium complex revealed negligible energetic preferences for one isomer despite the methyl groups in the 2‐methyl‐6‐phenylpyridyl cyclometalating ligands being close to the neighboring methyl groups and the bridge, thus supporting the experimental findings of isomer mixtures. Two distinct broad emissions with maxima at 522–529 nm and at 689–701 nm observed in these complexes in dichloromethane are attributed to mixed metal‐ligand to ligand charge transfer (MLLCT) excited states involving the pyridyl and bridge moieties respectively with the aid of electronic structure computations.
Industrial Fragrance Chemistry: A Brief Historical Perspective
Authors: David Olivier R. P. , Doro Franco 
Published: September 2023

AbstractPerfumery has evolved from a handcraft activity, marking supreme aristocratic luxury in the Renaissance, to a global industry powering scent experiences for present‐day consumers through the use of a myriad of consumer packaged goods. This contribution reviews major breakthroughs in the field, including landmark fragrance ingredients, technological advances in scent delivery, and key innovations in consumer products which created the demand for scientific and technological advancements in the scent domain. These innovations are presented chronologically, relying solely on information drawn from public written sources, spanning a time period of 150 years (1870–2020). We hope with this contribution to generate interest in the readership for this fascinating field, while celebrating 150 years of innovation for scented mass‐market products.