bluuebunny/crossref_metadata_2025_split huggingface dataset:
[18F]FDG PET in conditions associated with hyperkinetic movement disorders and ataxia: a systematic review
Authors: Timmers Elze R. , Klamer Marrit R. , Marapin Ramesh S. , Lammertsma Adriaan A. , de Jong Bauke M. , Dierckx Rudi A. J. O. , Tijssen Marina A. J. 
Published: January 2023

Abstract

Purpose
To give a comprehensive literature overview of alterations in regional cerebral glucose metabolism, measured using [18F]FDG PET, in conditions associated with hyperkinetic movement disorders and ataxia. In addition, correlations between glucose metabolism and clinical variables as well as the effect of treatment on glucose metabolism are discussed.

Methods
A systematic literature search was performed according to PRISMA guidelines. Studies concerning tremors, tics, dystonia, ataxia, chorea, myoclonus, functional movement disorders, or mixed movement disorders due to autoimmune or metabolic aetiologies were eligible for inclusion. A PubMed search was performed up to November 2021.

Results
Of 1240 studies retrieved in the original search, 104 articles were included. Most articles concerned patients with chorea (n = 27), followed by ataxia (n = 25), dystonia (n = 20), tremor (n = 8), metabolic disease (n = 7), myoclonus (n = 6), tics (n = 6), and autoimmune disorders (n = 5). No papers on functional movement disorders were included. Altered glucose metabolism was detected in various brain regions in all movement disorders, with dystonia-related hypermetabolism of the lentiform nuclei and both hyper- and hypometabolism of the cerebellum; pronounced cerebellar hypometabolism in ataxia; and striatal hypometabolism in chorea (dominated by Huntington disease). Correlations between clinical characteristics and glucose metabolism were often described. [18F]FDG PET-showed normalization of metabolic alterations after treatment in tremors, ataxia, and chorea.

Conclusion
In all conditions with hyperkinetic movement disorders, hypo- or hypermetabolism was found in multiple, partly overlapping brain regions, and clinical characteristics often correlated with glucose metabolism. For some movement disorders, [18F]FDG PET metabolic changes reflected the effect of treatment.
The Effect of Angioembolization Versus Open Exploration for Moderate to Severe Blunt Liver Injuries on Mortality
Authors: Gallaher Jared , Burton Victoria , Schneider Andrew B. , Reid Trista , Raff Lauren , Smith Charlotte B. , Charles Anthony 
Published: January 2023

AbstractIntroductionBlunt liver injury is common and is associated with a high morbidity and mortality. More severe injuries often require either angioembolization or open operative repair, depending on patient factors and facility capacity. We sought to describe patient outcomes based on intervention type.MethodsWe analyzed the National Trauma Data Bank (2017–2019) using ICD‐10 codes to identify adult patients with blunt liver injury and their interventions. AIS (Abbreviated Injury Scale) scores were used to group patients based on liver injury severity (AIS 2–6). Logistic regression modeling was used to estimate the adjusted odds ratio of death based on intervention type, excluding patients with severe injury.ResultsOf 2,848,592 trauma patients, 50,250 patients had a blunt liver injury. Among patients with AIS 3/4/5 injury, 1,140 had angioembolization, 1,529 had an open repair, and 188 had both angioembolization and open repair. In comparison with no intervention and adjusted for age, sex, shock index, ISS, and transfusion total (first four hours), angioembolization was associated with a significant decrease in the odds of mortality for patients with an AIS 4 (OR 0.68, 95% CI 0.47, 0.99) and AIS 5 injury (OR 0.39, 95% CI 0.24, 0.64). In patients with an AIS 5 injury, open repair had an increased odds of mortality at OR 1.99 (95% CI 1.47, 2.69).ConclusionIn an analysis of a national trauma database, patients with a moderate to severe injury (AIS 4 or 5), angioembolization was associated with a significant reduction in the adjusted odds of mortality compared to open repair and should be considered when clinically appropriate.
Interactions between natural products and cancer treatments: underlying mechanisms and clinical importance
Authors: Chan Wai-Jo Jocelin , Adiwidjaja Jeffry , McLachlan Andrew J. , Boddy Alan V. , Harnett Joanna E. 
Published: January 2023

AbstractNatural products, also referred to as dietary supplements, complementary and alternative medicines, and health or food supplements are widely used by people living with cancer. These products are predominantly self-selected and taken concurrently with cancer treatments with the intention of improving quality of life, immune function and reducing cancer symptoms and treatment side effects. Concerns have been raised that concurrent use may lead to interactions resulting in adverse effects and unintended treatment outcomes. This review provides an overview of the mechanisms by which these interactions can occur and the current evidence about specific clinically important natural product–drug interactions. Clinical studies investigating pharmacokinetic interactions provide evidence that negative treatment outcomes may occur when Hypericum perforatum, Grapefruit, Schisandra sphenanthera, Curcuma longa or Hydrastis canadensis are taken concurrently with common cancer treatments. Conversely, pharmacodynamic interactions between Hangeshashinto (TJ-14) and some cancer treatments have been shown to reduce the side effects of diarrhoea and oral mucositis. In summary, research in this area is limited and requires further investigation.
In-situ observations of an intact natural whale fall in Palmer deep, Western Antarctic Peninsula
Authors: Bolstad K. S. R. , Amsler M. O. , Broyer C. De , M. Komoda  , Iwasaki H. 
Published: January 2023

AbstractWhale carcasses on the seafloor support unique, ephemeral communities of organisms, and ‘natural’ whale fall sites are infrequently encountered, especially in polar regions. During a manned submersible dive in early 2017, we discovered the skeleton of an Antarctic minke whale (Balaenoptera bonaerensis) at 963 m in Palmer Deep, in the Western Antarctic Peninsula. The site was filmed in HD for approximately two hours, enabling visual identification of representatives from at least eight phyla, although physical sampling was not possible. The remains appeared to be in the late ‘enrichment–opportunistic’ phase (although some mobile scavengers were still present and some sulfonic activity had already commenced), with polychaetes of the order Aciculata, and family Ampharetidae, plus several amphipod species, most abundant. Novel eusirid amphipod and rhodaliid siphonophore taxa were also present. The observed faunal distribution suggests patterns consistent with reports from other Antarctic whale falls (both experimental and natural). This discovery represents the highest-latitude natural whale fall reported to date.
Particle detection and size recognition based on defocused particle images: a comparison of a deterministic algorithm and a deep neural network
Authors: Sachs Sebastian , Ratz Manuel , Mäder Patrick , König Jörg , Cierpka Christian 
Published: January 2023

AbstractThe systematic manipulation of components of multimodal particle solutions is a key for the design of modern industrial products and pharmaceuticals with highly customized properties. In order to optimize innovative particle separation devices on microfluidic scales, a particle size recognition with simultaneous volumetric position determination is essential. In the present study, the astigmatism particle tracking velocimetry is extended by a deterministic algorithm and a deep neural network (DNN) to include size classification of particles of multimodal size distribution. Without any adaptation of the existing measurement setup, a reliable classification of bimodal particle solutions in the size range of$$1.14~\upmu \hbox {m}$$1.14μm–$$5.03~\upmu \hbox {m}$$5.03μmis demonstrated with a precision of up to 99.9 %. Concurrently, the high detection rate of the particles, suspended in a laminar fluid flow, is quantified by a recall of 99.0 %. By extracting particle images from the experimentally acquired images and placing them on a synthetic background, semi-synthetic images with consistent ground truth are generated. These contain labeled overlapping particle images that are correctly detected and classified by the DNN. The study is complemented by employing the presented algorithms for simultaneous size recognition of up to four particle species with a particle diameter in between$$1.14~\upmu \hbox {m}$$1.14μmand$$5.03~\upmu \hbox {m}$$5.03μm. With the very high precision of up to 99.3 % at a recall of 94.8 %, the applicability to classify multimodal particle mixtures even in dense solutions is confirmed. The present contribution thus paves the way for quantitative evaluation of microfluidic separation and mixing processes.
A 2-Bisection with Small Number of Monochromatic Edges of a Claw-Free Cubic Graph
Authors: Eom Seungjae , Ozeki Kenta 
Published: January 2023

AbstractA bisection of a graph G is a partition of its vertex set into two parts of the same cardinality. A k-bisection of G is a bisection of G such that every component of each part has at most k vertices. Cui and Liu proved that every claw-free cubic graph contains a 2-bisection. In this paper, we improve this result showing that every claw-free cubic graph contains a 2-bisection with bounded number of monochromatic edges, where a monochromatic edge of a 2-bisection is an edge connecting two vertices of the same part of the 2-bisection. We also prove that our bound is best possible for all claw-free cubic simple graphs.
Mechanisms of tropical cyclone response under climate change in the community earth system model
Authors: van Westen René M. , Dijkstra Henk A. , Bloemendaal Nadia 
Published: January 2023

AbstractClimate change induces a myriad of effects which influences the global tropical cyclone (TC) genesis frequency. Here we explore how North Atlantic and Western Pacific TCs are affected under climate change using a present-day and a future (1% pCO2 scenario) ensemble of high resolution simulations. We find that the number of TCs decreases ($$-45\%$$

-
45
%

) in the North Atlantic but increases ($$+15\%$$

+
15
%

) in the Western Pacific. Part of these opposing variations are linked to differences in the ocean’s meridional overturning circulation, which gives rise to a different sea surface temperature response and air-sea fluxes between the two basins. The results show the important role of oceanic climate change on TC response.
Non-visual hallucinations in Parkinson’s disease: a systematic review
Authors: Toh Wei Lin , Yolland Caitlin , Gurvich Caroline , Barnes James , Rossell Susan L. 
Published: January 2023

AbstractBackgroundNon-visual hallucinations in Parkinson’s disease (PD) can be prevalent and distressing. Most existing research has however, focused on visual hallucinations as well as related risk factors. The current study thus conducted a systematic review to collate existing evidence on non-visual hallucinations in PD, focusing on their prevalence, phenomenology, and clinical-cognitive correlates.MethodsNinety-one relevant studies were included from a systematic search across PsycINFO APA, PubMed, and Web of Science, for peer-reviewed publications in the English language, from 1970 to the present. These comprised a mix of case (30 studies;n = 56) and group design (62 studies;n = 7346) studies, divided into three somewhat overlapping collections to address our three research foci.ResultsPrevalence estimates for hallucinations were: auditory 1.5–72.0%, olfactory 1.6–21.0%, somatic-tactile 0.4–22.5%, gustatory 1.0–15.0%, and sensed presence 0.9–73.3%. Phenomenological inquiries revealed descriptions of vivid, consuming events replete with elaborate detail, adversely affecting PD patients in different ways. Overt experiences of multisensory hallucinations were also highly variable (0.4–80%) but exceedingly common, reported by almost half of the 45 included prevalence studies. There was some evidence for modality-specific hallucination predictors, but this was largely tentative, pending robust replication.ConclusionsMarked prevalence figures coupled with phenomenological descriptions implicating distress denote that non-visual and multisensory hallucinations in PD are of clinical significance. More direct research and clinical attention need to be devoted to the study and management of such hallucinatory experiences.
The effects of enteric-coated sodium bicarbonate supplementation on 2 km rowing performance in female CrossFit® athletes
Authors: Martin Robyn A. X. J. , Hilton Nathan P. , Sparks S. Andy , Saunders Bryan , McNaughton Lars R. 
Published: January 2023

Abstract
Purpose
Sodium bicarbonate (SB) supplementation can improve exercise performance, but few studies consider how effective it is in female athletes. The aim of the study was to establish the effect of individually timed pre-exercise SB ingestion on 2 km rowing time trial (TT) performance in female athletes.

Methods
Eleven female CrossFit® athletes (mean ± SD age, 29 y ± 4 y, body mass, 64.5 kg ± 7.1 kg, height, 1.7 m ± 0.09 m, peak oxygen uptake [VO2peak], 53.8 ± 5.7 mL·kg−1∙min−1). An initial trial identified individual time-to-peak [HCO3−] following enteric-coated 0.3 g·kg−1 BM SB ingestion. Participants then completed a 2 km TT familiarisation followed by a placebo (PLA) or SB trial, using a randomised cross-over design.

Results
The ingestion of SB improved rowing performance (514.3 ± 44.6 s) compared to the PLA (529.9 ± 45.4 s) and FAM trials (522.2 ± 43.1 s) (p = 0.001, pη2 = 0.53) which represents a 2.24% improvement compared to the PLA. Individual time-to-peak alkalosis occurred 102.3 ± 22.1 min after ingestion (range 75–150 min) and resulted in increased blood [HCO3-] of 5.5 ± 1.5 mmol⋅L−1 (range = 3.8–7.9 mmol⋅L−1). The change in blood [HCO3-] was significantly correlated with the performance improvement between PLA and SB trials (r = 0.68, p = 0.020).

Conclusions
Ingesting a 0.3 g·kg−1 BM dose of enteric-coated SB improves 2 km rowing performance in female athletes. The improvement is directly related to the extracellular buffering capacity even when blood [HCO3-] does not change ≥ 5.0 mmol⋅L−1.
Near-Optimal Quantum Algorithms for String Problems
Authors: Akmal Shyan , Jin Ce 
Published: January 2023

AbstractWe study quantum algorithms for several fundamental string problems, including Longest Common Substring, Lexicographically Minimal String Rotation, and Longest Square Substring. These problems have been widely studied in the stringology literature since the 1970s, and are known to be solvable by near-linear time classical algorithms. In this work, we give quantum algorithms for these problems with near-optimal query complexities and time complexities. Specifically, we show that: Longest Common Substring can be solved by a quantum algorithm in $$\tilde{O}(n^{2/3})$$

O
~

(

n

2
/
3

)

time, improving upon the recent $$\tilde{O}(n^{5/6})$$

O
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(

n

5
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6

)

-time algorithm by Le Gall and Seddighin (in: Proceedings of the 13th innovations in theoretical computer science conference (ITCS 2022), pp 97:1–97:23, 2022. https://doi.org/10.4230/LIPIcs.ITCS.2022.97). Our algorithm uses the MNRS quantum walk framework, together with a careful combination of string synchronizing sets (Kempa and Kociumaka, in: Proceedings of the 51st annual ACM SIGACT symposium on theory of computing (STOC 2019), ACM, pp 756–767, 2019. https://doi.org/10.1145/3313276.3316368) and generalized difference covers. Lexicographically Minimal String Rotation can be solved by a quantum algorithm in $$n^{1/2 + o(1)}$$

n

1
/
2
+
o
(
1
)

time, improving upon the recent $$\tilde{O}(n^{3/4})$$

O
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(

n

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4

)

-time algorithm by Wang and Ying (in: Quantum algorithm for lexicographically minimal string rotation. CoRR, 2020. arXiv:2012.09376). We design our algorithm by first giving a new classical divide-and-conquer algorithm in near-linear time based on exclusion rules, and then speeding it up quadratically using nested Grover search and quantum minimum finding. Longest Square Substring can be solved by a quantum algorithm in $$\tilde{O}(\sqrt{n})$$

O
~

(

n

)

time. Our algorithm is an adaptation of the algorithm by Le Gall and Seddighin (2022) for the Longest Palindromic Substring problem, but uses additional techniques to overcome the difficulty that binary search no longer applies. Our techniques naturally extend to other related string problems, such as Longest Repeated Substring, Longest Lyndon Substring, and Minimal Suffix.
Ricci flow on surfaces along the standard lightcone in the $$3+1$$-Minkowski spacetime
Authors: Wolff Markus 
Published: January 2023

AbstractIdentifying any conformally round metric on the 2-sphere with a unique cross section of the standard lightcone in the $$3+1$$

3
+
1

-Minkowski spacetime, we gain a new perspective on 2d-Ricci flow on topological spheres. It turns out that in this setting, Ricci flow is equivalent to a null mean curvature flow first studied by Roesch–Scheuer along null hypersurfaces. Exploiting this equivalence, we can translate well-known results from 2d-Ricci flow first proven by Hamilton into a full classification of the singularity models for null mean curvature flow in the Minkowski lightcone. Conversely, we obtain a new proof of Hamilton’s classical result using only the maximum principle.
Microbial dynamics with CRC progression: a study of the mucosal microbiota at multiple sites in cancers, adenomatous polyps, and healthy controls
Authors: Senthakumaran Thulasika , Moen Aina E. F. , Tannæs Tone M. , Endres Alexander , Brackmann Stephan A. , Rounge Trine B. , Bemanian Vahid , Tunsjø Hege S. 
Published: January 2023

AbstractAccumulating evidence has related the gut microbiota to colorectal cancer (CRC). Fusobacterium nucleatum has repeatedly been linked to colorectal tumorigenesis. The aim of this study was to investigate microbial composition in different sampling sites, in order to profile the microbial dynamics with CRC progression. Further, we characterized the tumor-associated F. nucleatum subspecies. Here, we conducted Illumina Miseq next-generation sequencing of the 16S rRNA V4 region in biopsy samples, to investigate microbiota alterations in cancer patients, patients with adenomatous polyp, and healthy controls in Norway. Further, Fusobacterium positive tumor biopsies were subjected to MinION nanopore sequencing of Fusobacterium-specific amplicons to characterize the Fusobacterium species and subspecies. We found enrichment of oral biofilm-associated bacteria, Fusobacterium, Gemella, Parvimonas, Granulicatella, Leptotrichia, Peptostreptococcus, Campylobacter, Selenomonas, Porphyromonas, and Prevotella in cancer patients compared to adenomatous polyp patients and control patients. Higher abundance of amplicon sequence variants (ASVs) classified as Phascolarctobacterium, Bacteroides vulgatus, Bacteroides plebeius, Bacteroides eggerthii, Tyzzerella, Desulfovibrio, Frisingicoccus, Eubacterium coprostanoligenes group, and Lachnospiraceae were identified in cancer and adenomatous polyp patients compared to healthy controls. F. nucleatum ssp. animalis was the dominating subspecies. F. nucleatum ssp. nucleatum, F. nucleatum ssp. vincentii, Fusobacterium pseudoperiodonticum, Fusobacterium necrophorum, and Fusobacterium gonidiaformans were identified in five samples. Several biofilm-associated bacteria were enriched at multiple sites in cancer patients. Another group of bacteria was enriched in both cancer and polyps, suggesting that they may have a role in polyp development and possibly early stages of CRC.
Effect of labour income on the optimal bankruptcy problem
Authors: Ding Guodong , Marazzina Daniele 
Published: January 2023

AbstractIn this paper we deal with the optimal bankruptcy problem for agents who can optimally allocate their consumption rate, the amount of capital invested in the risky asset, as well as their leisure time. In our framework, the agents are endowed by an initial debt, and they are required to repay their debt continuously. Declaring bankruptcy, the debt repayment is exempted at the cost of a wealth shrinkage. We implement the duality method to solve the problem analytically and conduct a sensitivity analysis to the bankruptcy cost and benefit parameters. Introducing the flexible leisure/working rate, and therefore the labour income, into the bankruptcy model, we investigate its effect on the optimal strategies.
TEMPO-oxidized cellulose nanofibril/polyvalent cations hydrogels: a multifaceted view of network interactions and inner structure
Authors: Rossetti Arianna , Paciaroni Alessandro , Rossi Barbara , Bottari Cettina , Comez Lucia , Corezzi Silvia , Melone Lucio , Almásy László , Punta Carlo , Fiorati Andrea 
Published: January 2023

Abstract
In the last years, hydrogels from renewable biopolymers and low-cost row materials are a hot topic for biomedical applications. In this context, cellulose nanofibrils are considered suitable building blocks for the synthesis of many biocompatible products, with a variety of chemical-physical properties. Herein we report a multi-technique and multi-scale study, from the molecular to the nanometric length scale, of the sol–gel transition observed in aqueous solutions of TEMPO-oxidized nano-sized cellulose fibrils (TOCNFs), when in the presence of polyvalent cations (Mg2+ and Ca2+). We combine the data from Small Angle Neutron Scattering (SANS), which provide information about the inner structure of the nanofibril, with those from UV Resonant Raman (UVRR) spectroscopy, which is a sensitive probe of the intra- and inter-molecular interactions in the gel and the liquid state. The transition between the gel and the liquid phases is investigated as a function of the concentration of both TOCNFs and cations, the nature of the latter, and the pH at which the phenomenon is observed. SANS analysis reveals that ion concentration induces an anisotropic swelling in the nanofibrils which, at the same time, become more and more flexible. The nanofibrils flexibility is also dependent on TOCNF concentration and pH value. UVRR allows us to elucidate the structural organization and hydrogen-bonding properties of water in aqueous TOCNF dispersions and gels, showing how water molecules partially lose their typical bulk-like tetrahedral organization when ions are added, and the gel phase is formed.

Graphical abstract
Development of SNP molecular markers associated with resistance to reniform nematode in soybean using KASP genotyping
Authors: Wilkes Juliet E. , Fallen Benjamin , Saski Chris , Agudelo Paula 
Published: January 2023

AbstractReniform nematode (Rotylenchulus reniformis, Linford and Oliveira) is a sedentary, semi-endoparasite that infects a wide range of plant hosts and is one of the top three nematode pathogens affecting soybean in the southeastern United States. Previous studies have linked resistance to reniform nematode in soybean to two quantitative trait loci on chromosomes 11 and 18. A Kompetitive Allele-Specific PCR (KASP) assay was designed using SNP markers within these two regions to distinguish reniform nematode-resistant soybean based on genotype. A collection of 44 soybean plant introductions with resistant phenotype to reniform nematode and 40 susceptible soybean lines were genotyped at the two target loci to validate the KASP assay design. Of the 44 observed resistant lines, two carried the susceptible genotype; PI 438489B at the locus on chromosome 18 and PI 495017C on chromosome 11. Of the 40 observed susceptible soybean lines, only 25 had the expected susceptible genotype at the loci on chromosome 18 and 13 on chromosome 11. Our KASP assay was 68% accurate in predicting the phenotype of 84 soybean accessions based on their genotype at the SNP marker on chromosome 18 and 83% accurate at chromosome 11. These results indicate a moderate correlation of soybean SNP markers GlyREN18_46 and GlyREN11_190 with reniform nematode resistance. Further research is required to improve the accuracy of KASP assays to predict soybean response to reniform nematode, particularly host susceptibility.