bluuebunny/crossref_metadata_2025_split huggingface dataset:
Surgeons’ Perspectives on Liability for the Use of Artificial Intelligence Technologies in the United States and European Union: Results From a Focus Group Study
Authors: Duffourc Mindy , Møllebæk Mathias , Druedahl Louise C. , Minssen Timo , Gerke Sara 
Published: January 2025

Objective:
To examine surgeons’ perspectives on liability for using artificial intelligence (AI)-driven technologies in surgery in the United States and the European Union.

Background:
The introduction of AI-driven technologies in surgery can improve surgical performance and patient outcomes. However, liability risks might inhibit their implementation in the operating room. We report here the results of a focus group study that explored surgeons’ perspectives on liability for using AI-driven technologies in surgery in the United States and the European Union.

Methods:
Participants were identified through a call for participation disseminated through personal and professional networks. Inclusion criteria were: (1) adults (at least 18 years of age); (2) surgeons based in either the United States or in one of the European Union’s Member States, with a preference for those specializing in gastrointestinal surgery to facilitate better discussions about the vignettes that involved a colorectal surgical procedure; (3) ability to comfortably read and communicate in English; (4) willingness to consent to participation, and (5) willingness to consent to keeping the focus group meeting content, participants, and discussions confidential.

Results:
We conducted 6 focus groups via Zoom with a total of 18 participants (11 EU surgeons and 7 US surgeons). The following main themes emerged: (1) acknowledgment of the potential benefits of using AI-driven technology in surgery, (2) acceptance of surgeon responsibility, (3) recognition that AI may impact the standard of care, (4) skepticism about potential liability for AI manufacturers, and (5) the importance of patient information and consent.

Conclusions:
Despite the potential future benefits of integrating AI into surgical practice, surgeons will benefit from (1) an increased understanding of how AI-driven technologies will deliver these benefits and (2) increased clarity surrounding how AI-driven technologies will be governed by both regulators and the surgical community. While our study focused on surgeons’ perspectives, it could also provide valuable insights for other healthcare providers using AI to treat patients.
SPLASH Into Fitness
Authors: Kramer-Kostecka Eydie N. , Lewis Beth A. , Barr-Anderson Daheia J. 
Published: January 2025

Background:
Girls’ physical activity and healthful eating behaviors decline throughout adolescence. These trajectories may be linked to the underdevelopment of exercise and healthful eater identities. Youth programs might consider prioritizing identity development as an innovative health promotion strategy, especially during the formative preadolescent life stage.

Objectives:
This study examines healthful identities and behaviors among a sample of preadolescent girls who participated in SPLASH, a multicomponent youth program consisting of identity development (“I am an exerciser”; “I am a healthy eater”), physical activity, and healthful eating.

Methods:
SPLASH was piloted in a community-based recreational facility in the Midwest United States. Participants had differing levels of program access: all girls (N = 32, age = 10.6 ± 0.8) attended a 1-week summer day camp, and a subset (n = 16) received supplementary access to a 10-week eHealth program. Using a feasibility framework, we examined SPLASH’s (1) preliminary efficacy, (2) implementation, and (3) acceptability.

Results:
Girls’ exercise identities and behaviors improved following camp participation. At follow-up, those in the camp-plus-eHealth group reported greater improvements in physical activity enjoyment relative to girls in the camp-only group.

Conclusions:
SPLASH is a promising identity-focused health promotion program for preadolescent girls. Community support and family engagement facilitated this pilot study. Programmatic impact should be assessed in additional communities.
Synergistic effect of Cortex Moutan and Poria in protecting myocardium against ischemic injury based on network pharmacology
Authors: Wang Zhenrong , Tian Zhaowei , Liu Chenfeng , Wang Chen 
Published: January 2025

Objective:
To explore the potential mechanisms of Cortex Moutan-Poria synergistic effect in anti-myocardial ischemic injury based on network pharmacology.

Methods:
Active components from Cortex Moutan-Poria were identified using the TCMSP database, and their potential targets were predicted with the UniProt database. Gene targets related to myocardial ischemic injury were sourced from the TTD database. An analysis map linking the “herbal pair-active components-targets-disease” and corresponding protein networks were constructed using Cytoscape 3.10.1 software and the STRING platform, respectively. Enrichment analyses refer to the Kyoto Encyclopedia of the Genome (KEGG) pathway enrichment analyses and Gene Ontology (GO) databases for corresponding biological pathways and signalling pathway information for further exploration of the possible involvement of drug targets in downstream signalling.

Results:
A total of 17 active components of the Cortex Moutan-Poria herbal pair and 243 predicted targets were identified, among which 133 targets interacted with the active components in myocardial ischemic injury. Key genes associated with myocardial ischemic injury included B-cell lymphoma-2 (BCL-2), Jun N-terminal Kinase (JUN), Matrix Metallopeptidase 9 (MMP9), cysteine-dependent aspartate-specific proteases-3 (Caspase-3), Prostaglandin-Endoperoxide Synthase 2 (PTGS2), Interleukin-1β (IL-1β), Tumor Necrosis Factor (TNF), IL-6, Protein Kinase B (AKT1), and Stylonychia lemnae macronuclear development protein 6 (MDP6).

Conclusion:
The anti-myocardial ischemic injury effect of the Cortex Moutan-Poria combination is attributed to its multi-component, multi-target, and multi-pathway pharmacological properties. The pathways, core proteins, and major genes identified in this study for treating myocardial ischemic injury provide a theoretical foundation for subsequent experimental research.
Discovery of key genes and plant extracts in Sjögren’s syndrome with yin deficiency syndrome based on female patients clinical data & molecular docking
Authors: Li Haotian , Pang Fengtao , Xu Haodong , Yang Jianqin , Hu Sile , Yanjun Liu , Tang Xiaopo 
Published: January 2025

Background:
Primary Sjögren’s Syndrome (pSS) is an autoimmune disease, for which Traditional Chinese Medicine has shown significant therapeutic effects based on different syndrome types of Sjögren’s Syndrome. However, the research findings between it and related plant extracts are limited.

Objective:
To explore the symptoms of patients with yin deficiency syndrome and non-yin deficiency syndrome of Sjögren’s Syndrome and their relationship with plant extracts under the background of Traditional Chinese Medicine.

Methods:
Whole blood samples were collected from SS patients with yin deficiency syndrome (5), SS patients without yin deficiency syndrome (5), and healthy volunteers (5) for proteomic testing. Using healthy volunteers as the control group, the differential protein expression of SS with yin deficiency syndrome was screened for enrichment analysis and functional annotation; combining previous effective clinical cases and prescription drugs for data mining and network pharmacological analysis, potential effective plant extracts were screened and enriched. Finally, molecular docking was used to validate the results of network analysis, providing a highly probable new idea for the correlation between potential drug targets for SS patients with yin deficiency syndrome and potential effective plant extracts.

Results:
1. By analyzing the proteomic data of clinical samples, the differential genes of healthy individuals versus Sjögren’s Syndrome with yin deficiency versus Sjögren’s Syndrome without yin deficiency were discovered. By overlapping the above data, it was found that the key target genes for treating Sjögren’s Syndrome are HBA1, MST1, PCSK9, and HBB. 2. Enrichment analysis of plant extracts (PE) through clinical data mining of effective cases revealed the tremendous potential of four Chinese botanical drug - β-sitosterol, quercetin, berberine, and kaempferol in treating Sjögren’s Syndrome patients with yin deficiency syndrome. 3. The pathogenesis and regulation of Sjögren’s Syndrome with yin deficiency syndrome may be related to interleukin-related pathways, DNA synthesis, and oxidative stress. 4. Molecular docking suggests that berberine has good binding activity with MST1.

Conclusion:
We believe that berberine and MST1 may have significant research value in the treatment of Sjögren’s Syndrome with Female Patients. This study provides valuable reference points for future research on Sjögren’s Syndrome with yin deficiency syndrome.
Factors Influencing Postoperative Quality of Life in Korean Brain Tumor Survivors
Authors: Lim Soomin , Choi-Kwon Smi 
Published: January 2025

ABSTRACT

BACKGROUND: Patients with brain tumors continue to exhibit a lower quality of life than the general population, even after an extended period after surgery. Therefore, this study aimed to assess the postoperative quality of life of patients with brain tumors in South Korea and explore its determinants. METHODS: This study used a descriptive correlational design and collected data using questionnaires and electronic medical records. The collected data included the participants' characteristics, anxiety and depression levels, uncertainty, social support, and quality of life. Data analysis was performed using SPSS 29.0, with descriptive statistics, Pearson correlation analysis, and multiple regression analysis. RESULTS: Of the 117 subjects, 84 (71.8%) had benign tumors, and 33 (28.2%) had malignant tumors, with an average postoperative duration of 42.7 (51.0) months. Thirty-four participants (29%) reported experiencing depression, whereas the average uncertainty score was 91.8 (12.0) points. The average quality-of-life score was 67.52 (20.31) points, indicating a lower quality of life compared with the general population. Lower average monthly income (β = 0.174, P = .044), higher depression levels (β = −0.413, P < .001), and greater uncertainty (β = −0.230, P = .025) were associated with reduced quality of life. In terms of social support, family support was linked to quality of life but did not have a significant influence (P = .780), whereas healthcare provider support significantly affected quality of life (P = .015). CONCLUSION: This study highlights the persistent decline in the postoperative quality of life of patients with brain tumors due to depression and uncertainty, emphasizing the need for healthcare provider support. Clarifying these challenges, it may serve as a basis for developing nursing interventions to enhance survivors' long-term quality of life.
Ward-Based Staff Perspectives on Their Preparedness to Recognize Patient Deterioration: An Interpretive Description Study
Authors: MIKHAIL John , KING Lindy 
Published: January 2025

ABSTRACT

Background
Despite an overall decline in serious adverse events in hospitalized patients, approximately one third of inpatient mortality continues to relate to adverse events impacting patients on general wards. The preparedness of nurses, midwives, and nursing assistants (collectively referred to as ward-based staff) to recognize patient deterioration is therefore seen as critical.

Purpose
The aim of this study was to explore ward-based staff perspectives regarding their preparedness to recognize patient deterioration.

Methods
An interpretive description approach was utilized to interview 16 participants from a single-center regional hospital. The participants included nurses, midwives, and nursing assistants who worked exclusively on wards. The participants were purposely selected to complete semistructured interviews. Data were analyzed using a six-step thematic analysis, and the study followed the Standards for Reporting Qualitative Research checklist.

Results
Three main themes (with subthemes) were identified: (a) feeling prepared (experience, intuitive awareness, early warning systems), (b) promoting preparedness (multimodal education, debriefing, collegial support), and (c) being unprepared (undergraduate education, knowledge deficit, staffing related concerns, psychological response to incident, unforeseen barriers).

Conclusions/Implications for Practice
The findings suggest strategies for increasing knowledge and confidence in all ward-based staff, allowing them to feel better prepared to recognize clinical deterioration. Moreover, based on the results, ward-based staff strongly perceive experience, clinical shortfalls in undergraduate education, collegial support networks, mentorship, psychological response to incidents, and multimodal education to be key contributors to preparedness.
Soft Coagulation Versus Argon Plasma Coagulation After Large Non-pedunculated Colorectal Polyp Resection
Authors: Smith Eric , Wu Yizhong , Wang Yichen , Dahiya Dushyant Singh , Chandan Saurabh , Maida Marcello , Spadaccini Marco , Facciorusso Antonio , Shaukat Aasma , Ramai Daryl , Miranda Clive 
Published: January 2025

Introduction:
Thermal ablative methods (such as argon plasma coagulation (APC) and soft tip snare coagulation (STSC) are commonly used to treat polyp margins. We aim to appraise the current literature and compare clinical outcomes between patients with treated (with APC vs. STSC) and non-treated endoscopic mucosal resection (EMR) margins.

Methods:
We searched major databases from inception until November 2023 for randomly controlled trials (RCTs) comparing EMR of large non-pedunculated colorectal polyps with and without treated margins. Pooled data were analyzed for the primary outcome of recurrence at first screening colonoscopy, and adverse events. Analysis was performed using a random effects model and data were reported using 95% CIs.

Results:
A total of 5 RCT’s were found, which included 1020 polyps (577 in treatment and 443 in control groups). Three studies included treatment with STSC and 3 studies used APC as the modality for margin ablation. Of the included patients, 53% were female and the average age was similar between treatment and control groups (65.9 vs. 66.1 y). Seventy-one percent of lesions were proximal to the splenic flexure. The mean follow-up to the first colonoscopy and average polyp size were comparable (6.3 vs. 6.2 mo; 28.2 vs. 28.0 mm, respectively). Pooled analysis showed that margin ablation was associated with significantly lower rates of recurrence [odds ratio (OR) 0.267, 95% CI 0.18-0.4, P<0.001] with low heterogeneity between studies (I
2=0%, P=0.47). Pooled analysis showed no significant difference between STSC and APC in terms of recurrence (OR 0.6, 95% CI 0.27-1.7, I
2=0%, P=0.3) or adverse events (OR 0.67, 95% CI 0.3-1.6, I
2 13%, P=0.46).

Conclusion:
Our study shows that ablation of EMR margins is very effective at preventing recurrence at first surveillance colonoscopy. We found no difference between STSC or APC in terms of polyp recurrence or adverse outcomes.
Addressing the Shortage of Academic Nurse Educators
Authors: Brown Frederick , Pajarillo Edmund J. Y. , Baker Jordan , Kabigting Edwin-Nikko R. , Bajwa Maria , Dowling-Castronovo Annemarie , Kaufman Dulcinea , Santee Roseminda , Seibold-Simpson Susan M. , Lee Jan L. 
Published: January 2025

OBJECTIVES
This study examined how healthcare organization (HCO) leaders can impact the shortage of academic nurse educators (ANEs). A 2nd aim was to explore how HCOs, nurse leaders, and academic nursing programs can effectively collaborate to address the lack of ANEs.

BACKGROUND
The numbers of nursing school admissions and, thus, future nursing graduates are directly affected by the lack of qualified ANEs.

METHODS
A consortium of diverse ANEs was formed to research these questions using the nominal group technique.

RESULTS
Two central themes emerged from the consortium: support and collaboration. Recommendations are presented including a call for action for leaders of HCOs and academic nursing programs.

CONCLUSION
Findings of this research suggest that nurse leaders of HCOs and nursing programs develop solutions guided by these identified themes among other targeted interventions.
A Study Exploring Local Nurse Retention Data
Authors: Staup Amy , Jasin Lisa R. , Robinson Jamie , Hembree Shellie , Stolfi Adrienne , Bowling Ann 
Published: January 2025

OBJECTIVE
The purpose of this study was to identify the nursing perceptions and factors that affect nurse retention at this local freestanding pediatric hospital.

BACKGROUND
Currently in the United States, the demand for RNs is stronger than is being supplied. This site-specific pediatric RN turnover rate was estimated at 15% per year, which is above the national average.

METHODS
A descriptive correlational study was conducted using the Revised Casey-Fink Nurse Retention Survey tool.

RESULTS
The top 2 areas that impacted nursing retention at this study site were workplace morale, and pay and benefits. These data are inconsistent with multiple other studies where decreased job satisfaction and burnout were top factors in nursing retention.

CONCLUSIONS
Although national data reveal reasons for leaving an institution or the profession, it is important to survey the local workforce to identify areas for focus in retention efforts.
It’s Called “Informed Consent,” But How “Informed” Are Patients? A Patient Perspective on Informed Consent in a Tertiary Care Hospital in Saudi Arabia
Authors: Gray Jenny L. , Mrad Iskandar C. , AlAyed Aseel M. , AlHawas Fadwa A. , AbdulHameed Najlaa M. Faiq , Mahomed Zubeda B. , AlWtaid Mashail A. , Bany Hamdan Abdullah A. , AlHarbi AlWaleed M. , AlHasani Mohammed 
Published: January 2025

Objectives:
To examine the patient’s perspective of the informed consent process, particularly with regards to reading the informed consent form, understanding and recall of the informed consent.

Methods:
Between June and August 2022, 281 patients/proxies at King Fahad Medical City, Saudi Arabia, were surveyed within 7 days before having a medical procedure.

Results:
In all, 66.2% of patients did not read the consent before signing. Around 76.2% of patients said they fully understood the information given, 14.9% only partially understood, and 8.9% stated that they had not understood. A total of 90.4% of patients were able to recall their diagnosis. About 27.4% were unable to state any benefit of the procedure. In all, 19.9% were unaware if there was an alternative to the procedure. Around 40.6% were unable to state any risks and only 58.4% could remember at least one risk.

Conclusions:
A consent may be technically valid even when the patient has little understanding of the process; therefore, we must strive to ensure that we have ethically valid consent. From our findings, we conclude that informed consent has to be provided in an environment conducive to optimal patient understanding, for example, by ensuring that there is adequate time for explanation, preferably a day or 2 before the procedure. Informed consent should not be taken immediately before a (nonurgent) procedure. Secondly, due to the great variance in understanding between patients, it is vital for the physician to assess the patient’s understanding of the consent process, this may be achieved using feedback methodology.
The Relationship Between Medical Error Attitudes of Surgical Nurses and Evidence-Based Work Environment
Authors: Gökçe Esma , Doğan Aysel , Özer Demet 
Published: January 2025

Background:
It is important for health care professionals to use evidence-based practice during ﻿ surgical procedures to ensure patient safety and prevent medical errors.

Aims:
The aim of this study was to examine the relationship between surgical nurses’ perceptions of their work environment’s support for evidence-based practice and their attitudes toward medical errors.

Methods:
The descriptive cross-sectional study was conducted between February and May 2023. A total of 105 nurses participated in the study. A personal information form, a medical errors attitude scale, and an evidence-based practice work environment scale were used to collect the data.

Results:
It was determined that 92 (87.6%) of the participants used evidence-based practice. It was determined that the answers given by the nurses to the scales had very high reliability, and the mean score of the attitude scale in medical errors was 3.90 (Cronbach-α coefficient 0.770), and the mean score of the evidence-based practice work environment scale was 2.90 (Cronbach-α coefficient 0.840). In addition, according to the correlation, a positive, weak, and statistically significant correlation was found between the total scores of the attitude scale in medical errors and the evidence-based practice work environment scale (P<0.05).

Conclusion:
As a result of the study, it was determined that nurses’ attitudes toward preventing medical errors were positive and their perceptions of support for evidence-based practice work environments were high. In this direction, it can be said that the attitudes toward preventing medical errors of nurses whose working environment is supported by evidence-based practice can be positively affected and error tendencies in surgical clinics can be reduced.
EFFICACY AND SAFETY OF DOLUTEGRAVIR/LAMIVUDINE IN ANTIRETROVIRAL THERAPY-NAIVE PEOPLE LIVING WITH HIV-1 AND WITH HIGH-LEVEL VIREMIA
Authors: Calza Leonardo , Colangeli Vincenzo , Giglia Maddalena , Rigamonti Claudio , Bon Isabella , Cretella Silvia , Viale Pierluigi 
Published: January 2025

Background.
Dual regimen dolutegravir/lamivudine (DOL/3TC) showed potent efficacy and favourable safety in both antiretroviral therapy-naïve and -experienced patients, but data from real life about naive people with high-level viremia are still lacking.

Methods.
We performed a retrospective cohort study of people living with HIV (PLWH) who were naive to antiretroviral therapy, had baseline HIV-1 RNA ranging from 100000 to 500000 copies/mL, and initated DOL/3TC. Virological efficacy and changes in immunological parameters after 12 months of treatment were evaluated and compared with highly viremic PLWH who started a triple antiretroviral combination.

Results.
Inclusion criteria were met by 58 patients with median age of 43.4 years. At baseline, mean HIV RNA was 5.4 log10 and mean CD4 T lymphocyte count was 488 cells/mm3. HIV RNA <50 copies/mL was obtained in 45 patients (77.6% in the intention-to-treat analysis) after 6 months and in 53 (91.4%) after 12 months. Reasons for treatment failure were virological failure in two cases and adverse events in three. No significant changes in median value of lipids were reported, while there was a not significant increase in body weight (+1.18 Kg). Virological and immunological response at month 12 in patients on DOL/3TC was comparable to that observed in 50 naive patients with high-level viremia and starting a triple antiretroviral therapy.

Conclusion.
In this real-life cohort of naive patients with high-level viremia, DOL/3TC was associated with high virological efficacy and good tolerability after 12 months, supporting use of this dual regimen also in persons with high initial viremia.