bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hypersensitivity reactions to folinic acid: mechanisms involved based on two case reports and a literature review
Authors: Apraxine Matveï , Van den Eynde Marc , De Cuyper Astrid , Pirson Françoise 
Published: December 2022

Abstract
Background
Hypersensitivity reactions (HSR) to antineoplastic agents are an increasing problem, especially when they lead to treatment discontinuation, sometimes without any equivalent therapeutic option. HSR to folinic acid (FA), used particularly for the treatment of digestive carcinoma along with oxaliplatin and 5-fluorouracil, are rare. Only seven publications report HSR to FA, mainly confirmed by the disappearance of symptoms after the withdrawal of FA from chemotherapy. Only two papers describe allergy testing. Due to the difficult diagnosis, patients usually receive several further cycles of chemotherapy with progressively more intense symptoms before the withdrawal of FA.

Case presentation
Here we document two cases of HSR to FA, initially misattributed to oxaliplatin. The first patient described successive cycles with first back muscle pain, then chills and facial oedema and finally diffuse erythema with labial edema despite premedication. The allergy assessment highlighted high acute tryptase levels and intradermal tests positive for FA, pointing to an immunoglobulin E (IgE)-mediated mechanism. The second patient also had lower back muscle pain and chills in addition to tachycardia and desaturation during the administration of FA. Skin tests were negative and tryptase levels normal. After withdrawing FA, the symptoms did not recur, thus allowing the patient to continue chemotherapy. The mechanism of FA hypersensitivity is still unclear. The chronology of symptoms suggests an IgE-mediated mechanism that was not documented in the allergy assessment. A non-IgE-mediated mast cell/basophil activation could be involved, through complement activation or through Mas-related G protein-coupled receptors X2 (MRGPRX2) particularly.

Conclusions
These two cases of anaphylaxis to FA document the clinical manifestations associated with two different mechanisms of HSR. This paper provided the opportunity to review the limited literature on HSR to FA. Through these cases, we hope to draw the practitioner’s attention to FA as a potential agent of severe hypersensitivity, especially if symptoms remain after withdrawing the most suspected chemotherapeutic agents. We want also to stress the importance of allergy testing.
Automatic segmentation of prostate zonal anatomy on MRI: a systematic review of the literature
Authors: Wu Carine , Montagne Sarah , Hamzaoui Dimitri , Ayache Nicholas , Delingette Hervé , Renard-Penna Raphaële 
Published: December 2022

Abstract
Objectives
Accurate zonal segmentation of prostate boundaries on MRI is a critical prerequisite for automated prostate cancer detection based on PI-RADS. Many articles have been published describing deep learning methods offering great promise for fast and accurate segmentation of prostate zonal anatomy. The objective of this review was to provide a detailed analysis and comparison of applicability and efficiency of the published methods for automatic segmentation of prostate zonal anatomy by systematically reviewing the current literature.

Methods
A Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) was conducted until June 30, 2021, using PubMed, ScienceDirect, Web of Science and EMBase databases. Risk of bias and applicability based on Quality Assessment of Diagnostic Accuracy Studies 2 (QUADAS-2) criteria adjusted with Checklist for Artificial Intelligence in Medical Imaging (CLAIM) were assessed.

Results
A total of 458 articles were identified, and 33 were included and reviewed. Only 2 articles had a low risk of bias for all four QUADAS-2 domains. In the remaining, insufficient details about database constitution and segmentation protocol provided sources of bias (inclusion criteria, MRI acquisition, ground truth). Eighteen different types of terminology for prostate zone segmentation were found, while 4 anatomic zones are described on MRI. Only 2 authors used a blinded reading, and 4 assessed inter-observer variability.

Conclusions
Our review identified numerous methodological flaws and underlined biases precluding us from performing quantitative analysis for this review. This implies low robustness and low applicability in clinical practice of the evaluated methods. Actually, there is not yet consensus on quality criteria for database constitution and zonal segmentation methodology.
Proximal muscle weakness as the sole manifestation of Cushing’s disease, misdiagnosed as dermatomyositis: a case report
Authors: Jeddi Marjan , Shams Mesbah 
Published: December 2022

Abstract
Background
Cushing’s syndrome consists of signs and symptoms related to prolonged exposure to high levels of glucocorticoid, and should be considered in individuals with the discriminatory signs and symptoms. Proximal myopathy is an important discriminatory sign.

Case presentation
We report the case of a 36-year-old Iranian man who presented with proximal muscle weakness. He visited a rheumatologist in an outpatient clinic, and according to proximal muscle weakness and heliotrope rash (based on the rheumatologist’s notes) with the impression of dermatomyositis, prednisolone and azathioprine were prescribed for him that did not improve his clinical status and he was gradually wheelchair dependent. He was admitted to the hospital for evaluation of paraneoplastic syndromes. Standard laboratory tests and imaging were unremarkable, other than a brain magnetic resonance imaging that demonstrated a 30 × 12 mm homogeneously enhancing mass in the sellar region with extension to the suprasellar area. He had serum cortisol of 295 ng/mL, and adrenocorticotropic hormone of 222 pg/mL (on 5 mg prednisolone twice daily), with a diagnosis of Cushing’s disease. He underwent two sessions of trans-sphenoidal surgery 4 months apart. After the first surgery, the proximal muscle weakness improved dramatically and he was walking with the aid of a walker, and after the second surgery he is walking without any aids.

Conclusion
This case report emphasizes the high diagnostic importance of proximal muscle weakness as the sole presenting manifestation of Cushing’s syndrome/disease.
Co-treatment with grape seed extract and mesenchymal stem cells in vivo regenerated beta cells of islets of Langerhans in pancreas of type I-induced diabetic rats
Authors: Farid Alyaa , Haridyy Hebatallah , Ashraf Salma , Ahmed Selim , Safwat Gehan 
Published: December 2022

Abstract
Background
Nowadays, diabetes mellitus is known as a silent killer because individual is not aware that he has the disease till the development of its complications. Many researchers have studied the use of stem cells in treatment of both types of diabetes. Mesenchymal stem cells (MSCs) hold a lot of potential for regenerative therapy. MSCs migrate and home at the damaged site, where they can aid in the repair of damaged tissues and restoring their function. Oxidative stress and inflammation represent a huge obstacle during MSCs transplantation. Therefore, the present study aimed to evaluate the role of grape seed extract (GSE) administration during MSCs transplantation in streptozotocin (STZ)-induced type I diabetes. Furthermore, testing some of GSE components [procyanidins(P)-B1 and P-C1] in conjunction with MSCs, in vivo, was performed to determine if one of them was more effective in relieving the measured attributes of diabetes more than the whole GSE.

Methods
Firstly, GSE was prepared from the seeds of Muscat of Alexandria grapes and characterized to identify its phytochemical components. Experimental design was composed of control group I, untreated diabetic group II, GSE (300 mg/kg)-treated diabetic group III, MSCs (2 × 106 cells/rat)-treated diabetic group IV and GSE (300 mg/kg)/MSCs (2 × 106 cells/rat)-treated diabetic group V. Type I diabetes was induced in rats by intravenous injection with 65 mg/kg of STZ. Treatment started when fasting blood glucose (FBG) level was more than 200 mg/dl; GSE oral administration started in the same day after MSCs intravenous injection and continued daily for 30 consecutive days.

Results
The results showed that GSE/MSCs therapy in type I-induced diabetic rats has dramatically managed homeostasis of glucose and insulin secretion; together with, improvement in levels of inflammatory markers and oxidative stress.

Conclusion
Co-treatment with GSE and MSCs in vivo regenerates beta cells in type I-induced diabetic rats.
Caprine milk as a source of income for women instead of a taboo: a comparative analysis of the implication of women in the caprine and bovine value chains in Fatick, Senegal
Authors: Habanabakize Ernest , Diasse Mame Astou , Cellier Marjorie , Toure Katim , Wade Idrissa , Ba Koki , Camara Astou Diao , Cortbaoui Patrick , Corniaux Christian , Vasseur Elsa 
Published: December 2022

AbstractDomestic animals, especially small ruminants, are an important source of income for millions of smallholder farmers, particularly women, in Senegal. The aim of this study was to understand the place of the bovine and caprine milk value chains and to identify the role and challenges for women in the Fatick livestock production sector. A survey was conducted among a sample of 50 female producers, including 30 and 20 from the bovine and caprine milk value chains, respectively. Descriptive statistics were performed to compare the caprine and bovine milk value chains in terms of activities, products, and implications for household incomes while showing the place of women at different links of these value chains. The result of the study showed that the bovine milk value chain provided higher income compared to the caprine’s, but the latter was found to be more diverse in terms of milk-derived products with increased income opportunities’ potential. Remoteness, lack of equipment, and cultural biases were reported to be the main constraints in the caprine value chain, while milk price fluctuations were reported to be the biggest challenge for producers in the bovine milk value chain. Access to land and government subsidy programs and domestic time management were the main and specific challenges affecting women in the bovine and caprine value chains. Therefore, there is a need for the establishment of policies and interventions that consider the needs, opportunities, and complementarity offered by both the caprine and bovine milk value chains across smallholder women settings, while putting gender mainstreaming at the center of the discussions and reforms.
Profile and determinants of delayed care-seeking and diagnosis among patients with imported malaria: a retrospective study in China, 2014–2021
Authors: Zhang Tao , Wang Duoquan , Qian Yingjun , Ruan Wei , Liu Ying , Xia Jing , Yan Hui , Sui Yuan , Lu Shenning , Xu Xian , Jiang Jingjing , Lyu Xiaofeng , Wang Shuqi , Li Shizhu , Li Weidong 
Published: December 2022

Abstract
Background
In areas where malaria has been eliminated, delayed care-seeking and diagnosis of imported malaria are constant threats. This study aimed to describe the profile and determinants of delayed care-seeking and diagnosis among patients with imported malaria in China.

Methods
This retrospective study assessed surveillance data obtained from 2014 to 2021 in the Chinese provincial-level administrative divisions (PLADs) of Anhui, Henan, Hubei, and Zhejiang, and Guangxi. Epidemiological characteristics were analyzed using descriptive statistics. Furthermore, factors associated with delayed care-seeking and diagnosis among imported malaria cases were identified using multivariate logistic regression.

Results
Overall, 11.81% and 30.08% of imported malaria cases had delays in seeking care and diagnosis, respectively. During the study period, there was a decreasing trend in the proportion of imported malaria cases with delayed care-seeking (χ2 = 36.099, P < 0.001) and diagnosis (χ2 = 11.395, P = 0.001). In multivariate analysis, independent risk factors associated with delayed care-seeking include PLADs (Guangxi as reference), consultations in high-level facilities for the first medical visit, infections with non-Plasmodium falciparum species, and older age. However, PLADs (Guangxi as reference), the purpose of traveling (labour as reference), and infections with non-P. falciparum species increased the risk of delayed diagnosis. Delayed care-seeking (adjusted odds ratio: 1.79, P = 0.001) and diagnosis (adjusted odds ratio: 1.62, P = 0.004) were risk factors for severe disease development.

Conclusions
Based on this study’s findings, we strongly advocate for improved access to quality healthcare to reduce the rate of misdiagnosis at the first visit. Infections caused by non-P. falciparum species should be highlighted, and more sensitive and specific point-of-care detection methods for non-P. falciparum species should be developed and implemented. In addition, education programs should be enhanced to reach target populations at risk of malaria infection. All these factors may reduce delayed care-seeking and diagnosis of imported malaria.

Graphical Abstract
Bayesian calibration of coupled computational mechanics models under uncertainty based on interface deformation
Authors: Willmann Harald , Nitzler Jonas , Brandstäter Sebastian , Wall Wolfgang A. 
Published: December 2022

AbstractCalibration or parameter identification is used with computational mechanics models related to observed data of the modeled process to find model parameters such that good similarity between model prediction and observation is achieved. We present a Bayesian calibration approach for surface coupled problems in computational mechanics based on measured deformation of an interface when no displacement data of material points is available. The interpretation of such a calibration problem as a statistical inference problem, in contrast to deterministic model calibration, is computationally more robust and allows the analyst to find a posterior distribution over possible solutions rather than a single point estimate. The proposed framework also enables the consideration of unavoidable uncertainties that are present in every experiment and are expected to play an important role in the model calibration process. To mitigate the computational costs of expensive forward model evaluations, we propose to learn the log-likelihood function from a controllable amount of parallel simulation runs using Gaussian process regression. We introduce and specifically study the effect of three different discrepancy measures for deformed interfaces between reference data and simulation. We show that a statistically based discrepancy measure results in the most expressive posterior distribution. We further apply the approach to numerical examples in higher model parameter dimensions and interpret the resulting posterior under uncertainty. In the examples, we investigate coupled multi-physics models of fluid–structure interaction effects in biofilms and find that the model parameters affect the results in a coupled manner.
Association between anticholinergic activity and xerostomia and/ or xerophthalmia in the elderly: systematic review
Authors: Prado-Mel E. , Ciudad-Gutiérrez P. , Rodríguez-Ramallo H. , Sánchez-Fidalgo S. , Santos-Ramos B. , Villalba-Moreno A. M. 
Published: December 2022

Abstract
Purpose
The aim of this work was to investigate the association between anticholinergic burden or anticholinergic drug use and xerostomia and/or xerophtalmia in elderly through a systematic review of the published literature.

Methods
A search was carried out in 3 databases (CINAHL, Embase and Pubmed). Studies conducted in people ≥65 years of age, who took anticholinergic medications, and measured the association between the anticholinergic burden or the use of these medications with the prevalence of xerostomia and / or xerophthalmia, published up to August 2022, were selected. Studies published in languages other than Spanish and/or English were excluded.

Results
One thousand two hundred eleven articles were identified, 10 were selected for this review: six cross-sectional studies, two cohorts, one case-control and one randomized controlled clinical trial. A total of 3535 patients included in the different studies were studied. The most used scales were the Anticholinergic Drug Scale (ADS) and the Anticholinergic Risk Scale (ARS). Four articles studied the relationship between the use of anticholinergic medication and the prevalence of xerostomia and / or xerophthalmia, finding a positive relationship with xerostomia in all of them. Another 6 measured the relationship between anticholinergic burden and xerostomia and / or xerophthalmia. Four found a positive relationship between anticholinergic burden and xerostomia and/or xerophthalmia.

Conclusions
Our findings suggest a clear relationship between the use of anticholinergic drugs or anticholinergic burden and the presence of xerostomia. This relationship was less conclusive in the case of xerophthalmia.
Incorporating personalized learning in a role-playing game environment via SID model: a pilot study of impact on learning performance and cognitive load
Authors: Zhong Lin 
Published: December 2022

AbstractWhile role-playing games and personalized learning have been regarded as effective tools to improve students’ learning, incorporating personalized learning into role-playing games is challenging and approaches are limited to cognitive and motivational variables. Aiming at expanding approaches to incorporate personalization into role-playing games, this study included affective and cognitive variables to develop a personalized role-playing game, guiding by the situational design model. A pilot study was conducted to examine the effectiveness of the game on students’ learning performance and cognitive load. Results showed that personalized role-playing game environment was effective in improving students’ performance, reducing extraneous load, and promoting germane load. This study also found that although decreased extraneous load, could leave students more GL capacity for efficient learning, this would not necessarily lead to performance improvement. Students need to be motivated to invest sufficient germane load to actively process the learning materials and thus, improve performance. The findings have several implications for future research designing personalized educational games aimed to promote efficient learning.
Recreational off-highway vehicle exposure, safety behaviors and crash experiences among adolescents
Authors: Jennissen Charles A. , Schaeffer Sienna E. , Hoogerwerf Pamela J. , Wetjen Kristel M. , Mulford Lauren J. , Champoux Katharine L. , Okoro Uche E. , Denning Gerene M. 
Published: December 2022

Abstract
Background
Recreational off-highway vehicles (ROVs), often called utility task vehicles (UTVs), are designed to be driven by those ≥ 16 years and manufacturers recommend passengers be at least 12 years old. This study’s objective was to determine Iowa adolescents’ exposure to ROVs, riders’ use of restraint devices, and crash prevalence.

Methods
Adolescents participating in the Safety Tips for ATV Riders (STARs) program at their schools were anonymously surveyed by the Iowa Off-Road Vehicle Safety Task Force from Fall 2014-Fall 2019. Frequency, bivariate (chi square and Fisher’s exact test) and logistic regression analyses were performed using SAS software, V.9.4.

Results
A total of 4,023 students (9–18 years) from 18 school districts participated. Overall, 68% reported having ridden in an ROV. The proportions having ridden an ROV by where participants lived were farm (85%) > country/not farm (73%) > town (60%), p < 0.0001. Of those asked additional ROV questions (n = 2152), 39% of ROV riders reported riding at least weekly in the previous 12 months. Of those riding ROVs in the past year, 29% reported having at least one crash. Males and respondents living on farms had higher percentages reporting crashes, as compared to females (31% vs. 24%, p = 0.005) and those living elsewhere (35% vs. 24%, p = 0.0003). Thirty-seven percent of ROV riders never or almost never wore their seatbelt. Seatbelt use was inversely proportional to age, p < 0.001. A higher proportion of females reported always or almost always wearing a seat belt (42% vs. 36%, p = 0.0016). Percentages never or almost never wearing seatbelts by residence were farm (47%) > country/not farm (38%) > town (32%), p = 0.0005. Almost daily riders and those reporting having been in a crash were both 1.7 times more likely to never or almost never wear a seatbelt as compared to infrequent riders and those without a crash, respectively.

Conclusions
Iowa adolescents frequently ride ROVs and often without a seatbelt, putting them at greater risk for serious injury or death in a crash. Almost 30% of riders reported an ROV-related crash in the past year. Our study identified a high-risk population that could be targeted for ROV safety education and other injury prevention efforts.
Investigation on air conditioning load patterns and electricity consumption of typical residential buildings in tropical wet and dry climate in India
Authors: Ramapragada Pavan , Tejaswini Dharani , Garg Vishal , Mathur Jyotirmay , Gupta Rajat 
Published: December 2022

AbstractThe residential sector accounts for around 24% of the total electricity consumption in India. Recent studies show that air conditioners (ACs) have become a significant contributor to residential electricity consumption. Further, it is predicted that by 2037, the demand for ACs will increase by four times due to their affordability and availability. Not many studies have been found on residential AC usage patterns and the factors (AC load, setpoint, hours of usage) that influence household electricity consumption. This paper investigates the residential AC usage patterns and AC’s contribution to total residential electricity consumption. Twenty-five urban homes from a wet and dry climatic region of India were monitored for nine months (in 2019) to determine overall household electricity consumption patterns, AC usage, and indoor environment during summer, monsoon, and winter. Analysis of seasonal consumption patterns shows a significant difference in electricity usage between homes with ACs and homes without ACs during the summer season. The average electricity consumption for AC homes was 15.1 kWh/day during summer, 6.6 kWh/day during monsoon, and 6.1 kWh/day during the winter season. Results showed that AC alone contributed to 39% of the total household consumption in summers. The peak AC usage in all homes is observed during sleep hours which was generally between 10:00 pm and 6:00 am and the average AC runtime was 6.2 h. The average indoor temperature was recorded as 26.9 °C during the AC ON period. The AC peak load, i.e., the maximum electricity demand during the AC ON period, is 1.7 kW on average during the study period. The average annual consumption of homes with ACs was 2881 kWh, and for non-AC homes, the consumption was 2230 kWh. Findings from our analysis provide a detailed understanding of AC consumption profiles and the difference in electricity consumption characteristics between AC and non-AC homes across different seasons.