bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of thermal–hydro–mechanical coupling on grouting in a single fracture under coal mine flowing water conditions
Authors: Zhang Dingyang , Liu Dangping 
Published: January 2025

AbstractGroundwater inrush is a hazard that always occurs during underground mining. Grouting is one of the most effective processes to seal underground water inflow for hazard prevention. In this study, grouting experiments are conducted by using a visualized transparent single‐fracture replica with plane roughness. Image processing and analysis are performed to investigate the thermo–hydro–mechanical coupling effect on the grouting diffusion under coal mine flowing water conditions. The results show that higher ambient temperature leads to shorter initial gel time of chemical grout and leads to a better relative sealing efficiency in the case of a lower flow rate. However, with a higher water flow rate, the relative sealing efficiency is gradually reduced under higher temperature conditions. The grouting pressure, the seepage pressure, and the temperature are measured. The results reveal that the seepage pressure shows a positive correlation with the grouting pressure, while the temperature change shows a negative correlation with the seepage pressure and the grouting pressure. The “equivalent grouting point offset” effect of grouting shows an eccentric elliptical diffusion with larger grouting distance and width under lower temperature conditions.
Adaptation of Archaeal Communities to Summer Hypoxia in the Sediment of Bohai Sea
Authors: Guo Xiaoxiao , Li Yanying , Song Guisheng , Zhao Liang , Wang Jing 
Published: January 2025

ABSTRACTUnderstanding the adaptation of archaea to hypoxia is essential for deciphering the functions and mechanisms of microbes when suffering environmental changes. However, the dynamics and responses of archaea to the sedimentary hypoxia in Bohai Sea are still unclear. In this study, the diversity, composition, and distribution of archaeal community in sediment along an inshore–offshore transect across the oxygen‐depleted area in the Bohai Sea were investigated in June, July, and August of 2021 by employing high‐throughput sequencing of 16S rRNA gene. Results indicated that the archaeal communities were dominated by Thermoproteota (80.61%), Asgardarchaeota (8.70%), and Thermoplasmatota (5.27%). Dissolved oxygen (DO) and NO3− were the two key factors shaping the distribution of archaeal communities, accounting for 49.5% and 38.3% of the total variabilities (p < 0.05), respectively. With the intensity of oxygen depletion, the diversity of archaeal communities increased significantly. Microbial networks revealed that Bathyarchaeia played a key role in interacting with both bacteria and other archaeal groups. Furthermore, adaptions to hypoxia of archaea were also displayed by variation in relative abundance of the predicted ecological functions and the metabolic pathways. The enrichment of specific nitrogen transformation enzymes showed the potential for nitrogen fixation and removal, which might contribute to the balance of N budget and thus facilitate the ecological restoration under eutrophication in Bohai Sea. Our results provided a new picture on ecological and metabolic adaptions to hypoxia by archaea, which will be beneficial to further investigations in extreme environments both theoretically and practically.
Genomics Reveal Population Structure and Intergeneric Hybridization in an Endangered South American Bird: Implications for Management and Conservation
Authors: Domínguez Marisol , Arantes Larissa S. , Lavinia Pablo D. , Bergjürgen Nicole , Casale Agustin I. , Fracas Pablo A. , Lijtmaer Darío A. , Tubaro Pablo , Sparmann Sarah , Mbedi Susan , Mazzoni Camila , Mahler Bettina , Tiedemann Ralph 
Published: January 2025

ABSTRACTGenomics is an invaluable tool for conservation, particularly for endangered species impacted by wildlife trafficking. This study uses genomic data to provide new insights to aid conservation and management of endangered species, using as a case study the Yellow cardinal (Gubernatrix cristata), a bird endemic to southern South America severely affected by illegal trade and the transformation of its natural habitat. We explore population structure within the Yellow cardinal, delimiting management units and describing connectivity among them. Additionally, we develop and assess the accuracy of a panel of 189 informative SNPs, and demonstrate how these can reliably assign confiscated individuals to one of the management units established. Lastly, we assess hybridization between the Yellow cardinal and the Diuca finch (Diuca diuca), which is reported to occur in regions of sympatry. We confirm that hybridization occurs, although it is not as common as previously thought, and that hybrids might be fertile, as we found evidence of backcrossing with Yellow cardinals. We discuss the implications of this introgression for the evolution and conservation of Yellow cardinals. Our study provides new, valuable information that can guide conservation efforts, comprising a test case for the use of genomics in combating illegal trafficking, with potential application beyond the case of the Yellow cardinal.
Metabolic dysfunction‐associated steatotic liver disease is associated with increased risks of heart failure
Authors: Chang Kai‐Chun , Su Tung‐Hung , Wu Cho‐Kai , Huang Shang‐Chin , Tseng Tai‐Chung , Hong Chun‐Ming , Hsu Shih‐Jer , Liu Chen‐Hua , Yang Hung‐Chih , Liu Chun‐Jen , Kao Jia‐Horng 
Published: January 2025

AbstractAimsMetabolic dysfunction‐associated steatotic liver disease (MASLD), defined by steatotic liver disease (SLD) and cardiometabolic factors, is increasing in prevalence, but its association with heart failure (HF) is unclear.Methods and resultsPatients with SLD without a history of HF from 2006 to 2021 were retrospectively included and were classified into MASLD and non‐MASLD groups that were followed longitudinally. The primary outcome was the new development of HF, which was sub‐classified by echocardiography. Multivariable and propensity score matching analyses were conducted to adjust for confounding factors. Overall, 26 676 patients with SLD were included, with a median age of 51 years and 71% classified as MASLD. During a median follow‐up of 6 years, 429 (1.61%) patients developed HF, and 76% were HF with preserved ejection fraction (HFpEF). The risk of HF was significantly higher in patients with MASLD than in those without (sub‐distribution hazard ratio [SHR] 2.59, 95% confidence interval [CI] 1.84–3.64) after adjustment of competing mortality. There was a dose‐dependent increase in HF risks in patients with more cardiometabolic risk factors (SHR 1.12, 95% CI 1.04–1.22). MASLD was also associated with higher risk of HF‐related hospitalization (SHR 2.30, 95% CI 1.31–4.04) and specifically, the risk of HFpEF (SHR 1.91, 95% CI 1.27–2.86). In propensity score‐matched cohorts, MASLD was also associated with a 2.52‐fold higher risk of HF.ConclusionIn patients with SLD, those with MASLD show a higher risk of HF, specifically HFpEF. Future studies are warranted to validate the association between HF and MASLD.
A Review of High‐Temperature Molten Salt for Third‐Generation Concentrating Solar Power
Authors: Liu Xu , Zhong Yuan , Li Jinli , Wang Huaiyou , Wang Min 
Published: January 2025

ABSTRACTCurrent concentrating solar power (CSP) systems operate below 550°C, achieving annual electricity generation efficiencies of 10%–20%, which primarily employs nitrate molten salts as heat transfer fluids (HTFs). However, nitrate salts decompose at temperature exceeding 600°C, rendering them unsuitable for next‐generation CSP systems, which aim to operate above 700°C. This review presents the first comprehensive analysis of high‐temperature molten salts for third‐generation CSP systems. This highlights the potential of carbonates, chlorides, and sulfates as HTFs due to their extended operational temperature ranges. Guided by phase diagrams, multicomponent molten salts are systematically engineered to achieve desirable thermal properties. The review provides a detailed synthesis of compositions and working temperature ranges for these molten salts, with a particular focus on underexplored sulfate‐based salts. It consolidates critical data on the melting points and phase compositions of multicomponent sulfates and examines advancements in thermal property enhancements, including the integration of nanoparticles. By summarizing the latest progress and identifying future research directions, this work offers invaluable insights into the design and application of high‐temperature molten salts in next‐generation CSP systems.
Characterisation of Hedge Burning in the Context of Wildland Urban Interface (WUI) Fire Prevention
Authors: Tihay‐Felicelli Virginie , Meerpoel‐Pietri Karina , Santoni Paul‐Antoine , Perez‐Ramirez Yolanda , Graziani Anthony , Morandini Frédéric , Luciani Camille , Mell William , Maranghides Alexander 
Published: January 2025

ABSTRACTWith global warming, the wildfire season tends to get longer, causing fatalities and devastating damage to human property. Although many countries have implemented fire risk prevention measures, particularly in Wildland Urban Interfaces (WUI), this finding shows that there are weaknesses in the prevention measures. This is mainly due to a lack of knowledge about WUI fire exposure conditions. This paper presents field‐scale experiments to characterise the burning of rockrose‐reconstructed hedges (6 × 1 × 1 m) close to a building in order to provide experimental data on heat release rate (HRR), flame front geometry, and heat fluxes to the building. The mean horizontal flame extent was 4.4 (±0.7) m with values up to 5.5 m. These values are generally higher than the minimum distance to be maintained between vegetation and buildings in most countries. The fire intensity ranged from 283 to 3479 kW/m, resulting in maximum values at 3 m from the hedge of up to 45.4 kW/m2 for the total heat flux and 38.1 kW/m2 for the radiant heat flux. However, the flame duration is short, averaging 112.8 (±27.1) s. This type of exposure is far from those used to test the fire resistance worldwide. Therefore, the data obtained in this study are crucial for improving fire risk prevention methods worldwide, whether for fuel management in defensible zones or for testing building materials to make buildings more resistant to wildfires.
A Comparative Study of Ignitibility and Combustibility Properties of Four Algerian Plants: Application to Wildland Fuels Classification
Authors: Krim F. Z. , Zekri N. , Boutchiche H. , Mosbah O. , Sahraoui S. 
Published: January 2025

ABSTRACTTo seek a fire‐resistant fuel, the reaction to fire of Algerian Phoenix dactylifera leaves known for their thermal resistance was compared to that of three highly flammable Algerian fuel particles: Eucalyptus globulus leaves and Pinus halepensis and Pinus canariensis needles. By using a small‐scale cone calorimeter, their thermal properties were investigated under a low irradiance of , while their ignition and combustion properties were examined with irradiances of and . Eucalyptus globulus leaves were found the most ignitable fuels with the largest released heat, while Phoenix dactylifera leaves were found by far the least ignitable fuels with the smallest released heat, particularly under large heat flux intensities. Based on a theoretical analysis of thermal and ignition properties, a new flammability/spreading index combining the ignitability and combustibility metrics was proposed to rank these fuels. This index was compared with the fire retardancy index used for polymer composites and adapted to these plants because it uses a cone calorimeter. A similar ranking order was obtained between the two indices for the considered fuels, where Eucalyptus globulus leaves were found by far the most fire‐spreading fuels particularly at large fire intensity. On the other hand, Phoenix dactylifera leaves appeared by far the least fire‐spreading fuels particularly at large fire intensity. The possible use of Phoenix dactylifera trees as extreme fire retardants in wildland fuel management, as well as their use at the wildland–urban Interface, are discussed, but these results should be confirmed at a large scale.
Lifetime Treatment Trajectories of Mantle Cell Lymphoma: Simulation Based Analysis of 20 Years of Real‐World Data
Authors: Harmanen Minna , Hujo Mika , Sund Reijo , Sorigue Marc , Khan Madiha , Prusila Roosa , Klaavuniemi Tuula , Kari Esa , Jantunen Esa , Sunela Kaisa , Rajamäki Aino , Alanne Erika , Kuitunen Hanne , Sancho Juan‐Manuel , Jukkola Arja , Rönkä Aino , Kuittinen Outi 
Published: January 2025

ABSTRACTMantle cell lymphoma is a rare type of B‐cell lymphoma, which is considered incurable yet treatable. In recent years, the treatment options of mantle cell lymphoma have multiplied, and the focus of treatment is expected to shift from traditional chemoimmunotherapy toward precision medicine. However, this development is hindered by the high costs of targeted therapies. To provide a baseline for future assessment of costs and benefits of new and emerging MCL treatments, we established a predictive simulated model of lifetime treatment trajectories based on a retrospective cohort of chemoimmunotherapy era patients diagnosed and treated between the year 2000 and 2020.
Priorities for research on improving health behaviours for optimal mental health of Australian university students: A twin‐panel Delphi study
Authors: Hutchesson Melinda J. , Stanton Robert , Johnson Natalie , Francis‐Taylor Rohan , Burrows Tracy , Fassnacht Daniel B. , Farrer Louise M. 
Published: January 2025

AbstractIssue AddressedUniversity students are at risk of poor health behaviours which negatively affect mental health and wellbeing. Informing the implementation of appropriate strategies to support Australian university students' health and wellbeing, requires quality evidence. This study aimed to identify research priorities for improving health behaviours to optimise mental health of Australian university students.MethodsA twin‐panel Delphi method comprising 32 experts across two panels (Panel 1: n = 24, Panel 2; n = 8), with three rounds of data collection, was utilised. In round one panellists identified up to five research priorities. Identified priorities were grouped into themes and in Round 2 panellists ranked their panels priorities using a 4‐point Likert scale (1 irrelevant, 2 peripheral, 3 important, 4 essential), and in Round 3 they ranked the importance of the priorities identified by the other panel.ResultsPanel 1 identified 35 research priorities in Round 1, and Panel 2 identified 11. Priorities were ranked based on the mean score, with strong, between‐panel agreement in the rankings for Panel 1's priorities. (rs = .68, p < .001) but not Panel 2 (rs = .32, p = .34). A list of 25 priorities was retained.ConclusionsPriorities were derived from experts and provided a further call to action for research targeting suicide prevention, social determinants, co‐design, behaviour change, and the effectiveness and accessibility of services.So What?With further input from students, universities and other stakeholders, these research priorities can guide research to optimise health behaviours and mental health of Australian university students.
Infant mental health integration into OB care leads to increased connection to services during the perinatal period
Authors: Jester Jennifer M. , Bengel Cierra , Issa Meriam , Duprey Michelle , Riggs Jessica L. , Hoffman Charity M. , Harris Sharnita D. , Muzik Maria , Rosenblum Katherine Lisa 
Published: January 2025

AbstractWe compared referrals and connection to care between perinatal patients: 90 receiving OB/GYN care in clinics with integrated behavioral health consultants with infant mental health specialization (IMH‐BHC), and 68 receiving traditional care, in the United States. Participants identified as: Native American/Alaskan native, 1.90%; Asian, .63%; African American, 58.23%; Middle Eastern, 6.96%; African National/Caribbean Islander, .63%; Latin‐American, 8.86%; and White, 28.48%.Approximately 80% of families in each group were offered referrals. By design, intervention women received mental health services during pregnancy; 16% of women in either group received postpartum mental health services. Intervention group participants were over three times as likely to engage in IMH home visiting. Treatment families were less likely to follow up with infant referrals, but also had fewer infant emergency room visits.All intervention participants met with an IMH‐BHC prior to recruitment; however, only 20% self‐reported encounters with a mental health professional, indicating these interactions may not be identified by the participants as mental health care; therefore, openness to treatment may be increased for women who feel stigma around mental health care.Given the importance of perinatal mental health, OB/GYN clinics and others serving perinatal patients may consider integrating IMH providers as part of the care team.
Comprehensive landscape of small non‐coding RNAs in large and small extracellular vesicles from human serum and plasma
Authors: Xie Gui‐Yan , Deng Yi‐Han , Liu Chun‐Jie , Guo An‐Yuan , Lei Qian 
Published: January 2025

AbstractSmall non‐coding RNAs (ncRNAs) are functional molecules contained within extracellular vesicles (EVs) that modulate various physiological and pathological processes. This study provides a comprehensive expression profile of seven types of small ncRNAs in serum‐ and plasma‐derived EVs under various conditions. Both large EVs (lEVs) and small EVs (sEVs) contain high proportions of miRNAs (∼28.2% in lEVs and ∼20.8% in sEVs) and ribosomal RNAs (∼24.0% in lEVs and ∼19.1% in sEVs). lEVs are enriched with more transfer RNA (∼38.8%) than sEVs, whereas sEVs have a greater abundance of Y RNA (∼22.5%). Notably, Y RNA is more abundant in sEVs obtained from aged samples (age ≥60 years), a pattern not observed in lEVs. Small ncRNAs are more diverse in serum‐derived EVs than plasma‐derived EVs. There is also a high degree of overlap (>50%) in the top 100 small ncRNAs identified in lEVs and sEVs. The miRNAs hsa‐miR‐16‐5p, hsa‐let‐7a‐5p, hsa‐miR‐142‐3p, and hsa‐miR‐103‐3p are consistently among the top 10 highly expressed small ncRNAs in plasma‐ and serum‐derived lEVs as well as in peripheral blood mononuclear cells. Serum‐derived sEVs in glioblastoma, breast cancer, prostate cancer, and gastric cancer contain specific, highly expressed miRNAs, snoRNAs, small nuclear RNAs, and piRNAs. These results elucidate the patterns of small ncRNA cargoes within lEVs and sEVs derived from serum and plasma under various physiological and pathological conditions and offer valuable insights for future diagnostic and therapeutic applications.
Transgenerational Reproductive and Developmental Toxicity Induced by N‐Nitrosodimethylamine and Its Metabolite Formaldehyde in Drosophila melanogaster
Authors: Tabares‐Mosquera Oscar Eduardo , Juárez‐Díaz Javier Andrés , Camacho‐Carranza Rafael , Ramos‐Morales Patricia 
Published: January 2025

ABSTRACTN‐Nitrosodimethylamine (NDMA) is a known water disinfection byproduct (DBP) characterized as a potent hepatotoxin, promutagen, and probable human carcinogen; this is because of the metabolites associated with its biotransformation. The metabolism of NDMA produces formaldehyde, another alkylating agent and DBP. Both compounds are generated from natural and anthropogenic sources, but the safety restrictions applied to NDMA do not extend to the uses of formaldehyde. Hence, potential health and ecological risks are of concern. Due to limited information on the long‐term effects of exposure to these compounds at environmentally relevant concentrations, this work aimed to compare the transgenerational reproductive and developmental toxicity of separate exposures to NDMA or its metabolite formaldehyde in Drosophila melanogaster over four generations. The parental flies were fed NDMA or formaldehyde (1.19E−06 to 5 mM) for 48 h during the third larval instar. Subsequent offspring (F1–F3) were grown under compound‐free conditions. In the parental generation, both exposures modified the time to emergence and reduced the number of progenies. NDMA, but not formaldehyde, was lethal, affected fertility, and weakly induced malformations. In the next generations, both exposures induced malformed flies and modified the number of offspring. Reproductive toxicity and malformations were maintained for at least three generations, suggesting that detrimental effects could extend to unexposed offspring. This is the first study reporting the associated individual transgenerational effects on reproduction and development between NDMA and its metabolite formaldehyde in D. melanogaster, highlighting the relevance of evaluating multiple generations to accurately determine the health and environmental risks of pollutants.
Quantitative fluorescent nanoparticle tracking analysis and nano‐flow cytometry enable advanced characterization of single extracellular vesicles
Authors: Mladenović Danilo , Brealey Joseph , Peacock Ben , Koort Kairi , Zarovni Nataša 
Published: January 2025

AbstractCurrent state‐of‐the‐art tools for analysing extracellular vesicles (EVs) offer either highly sensitive but unidimensional bulk measurements of EV components, or high‐resolution multiparametric single‐particle analyses which lack standardization and appropriate reference materials. This limits the accuracy of the assessment of marker abundance and overall marker distribution amongst individual EVs, and finally, the understanding of true EV heterogeneity. In this study, we aimed to define the standardized operating procedures and reference material for fluorescent characterization of EVs with two commonly used EV analytical platforms—nanoparticle tracking analysis (NTA) and nano‐flow cytometry (nFCM). We achieved quantitative fluorescence analyses on ZetaView NTA and NanoAnalyzer nFCM instruments, by utilizing yellow‐green FluoSpheres (FS) with assigned ERF (equivalent reference fluorophore) values. This standardization technique allowed for fluorescent EV signal to be expressed in ERF units (indicative of bound fluorescent antibodies per EV), thus enabling measurement of target protein marker abundance on individual EVs, and in the whole EV population. The NTA's and nFCM's limits of detection (LoD) were evaluated at 21 and 9 Alexa Fluor 488 (AF488) molecules, respectively. To complement the limited quantification of markers expressed in a few copies per single EV, in‐line bulk fluorescence measurements with a plate reader were performed. This provided absolute marker quantification and more insightful analyses of EV heterogeneity and marker stoichiometry. The standardization method outlined in this work unlocks the full analytical potential of NTA and nFCM, enabling cross‐platform data comparison. At the same time, it highlights some of the technical challenges and considerations and thus contributes to the ongoing efforts towards the development of EV analytical tools.