bluuebunny/crossref_metadata_2025_split huggingface dataset:
A CASE OF AVASCULAR NECROSIS OF THE BILATERAL CAPUT FEMORAL IN FEMALE PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS
Authors: Syahriani Femi , Muhammad Andry Usman  , Nur Fatma  
Published: July 2023

Nekrosis avaskular (osteonekrosis, nekrosis aseptik, atau nekrosis iskemik) keadaan patologi yang disebabkan oleh berbagai etiologi yang menyebabkan penurunan suplai vaskuler sehingga mengakibatkan iskemik tulang. Nekrosis avaskular meningkatkan morbiditas pada pasien systemic lupus erythematosus (SLE). Beberapa faktor yang berkontribusi yaitu suplai vaskular pada tulang, penggunaan kortikosteroid, vaskulitis, siklofosfamid dan SLE sendiri merupakan faktor risiko nekrosis avaskular. Dilaporkan kasus perempuan berusia 20 tahun datang ke rumah sakit dengan keluhan nyeri pada kedua pinggul menyebabkan pasien kesulitan dalam berjalan dan aktivitas fisik sehari-hari. Pasien didiagnosis SLE sejak tahun 2017 dan salah satu terapi yang dikonsumsi adalah glukokortikoid selain obat DMARD (Disease Modifiying Atritis Reumatoid Drugs). Pemeriksaan fisis didapatkan keterbatasan Range of Movement (ROM) baik fleksi maupun ekstensi pada hip join bilateral. Radiografi Hip Joint Bilateral didapatkan gambaran avaskular nekrotik kaput femoris bilateral. Selanjutnya dilakukan total hip replacement dan mengalami perbaikan.
The Wealth-Peace Connection: Human Development Index and Global Peace Index in Middle Eastern Nations
Authors: Djailani Syahla Aurelya , Surwandono  
Published: July 2023

This study investigates the relationship between the Human Development Index (HDI) and the Global Peace Index (GPI) in the Middle East. This quantitative analysis employs the Pearson correlation coefficient formula, with HDI as the independent variable and GPI as the dependent variable. The literature review utilizes numerous sources, including journals, books, news media, and the internet. The research sample included Yemen, Afghanistan, Iraq, the United Arab Emirates (UAE), Palestine, Saudi Arabia, Syria, Qatar, and Israel. HDI and GPI are strongly negatively correlated (-0.854), indicating that an increase in one variable (HDI) diminishes the other variable (GPI). Consequently, countries in the Middle East with higher levels of human development tend to have lower GPI scores, indicating that higher levels of human development are associated with a greater likelihood of peace in this region.
Natural history and clinical burden of moderate aortic stenosis: a systematic review and explorative meta-analysis
Authors: Morelli Martina , Galasso Michele , Esposito Giuseppe , Soriano Francesco Stefano , Nava Stefano , Da Pozzo Caterina , Bossi Irene , Piccaluga Emanuela , Bruschi Giuseppe , Maloberti Alessandro , Oliva Fabrizio , Oreglia Jacopo Andrea , Giannattasio Cristina , Montalto Claudio 
Published: July 2023

Aims
The mortality risk of patients with moderate aortic stenosis is not well known, but recent studies suggested that it might negatively affect prognosis. We aimed to assess the natural history and clinical burden of moderate aortic stenosis and to investigate the interaction of patients’ baseline characteristics with prognosis.

Methods
Systematic research was conducted on PubMed. The inclusion criteria were inclusion of patients with moderate aortic stenosis; and report of the survival at 1-year follow-up (minimum). Incidence ratios related to all-cause mortality in patients and controls of each study were estimated and then pooled using a fixed effects model. All patients with mild aortic stenosis or without aortic stenosis were considered controls. Meta-regression analysis was performed to assess the impact of left ventricular ejection fraction and age on the prognosis of patients with moderate aortic stenosis.

Results
Fifteen studies and 11 596 patients with moderate aortic stenosis were included. All-cause mortality was significantly higher among patients with moderate aortic stenosis than in controls in all timeframes analysed (all P < 0.0001). Left ventricular ejection fraction and sex did not significantly impact on the prognosis of patients with moderate aortic stenosis (P = 0.4584 and P = 0.5792), while increasing age showed a significant interaction with mortality (estimate = 0.0067; 95% confidence interval: 0.0007–0.0127; P = 0.0323).

Conclusion
Moderate aortic stenosis is associated with reduced survival. Further studies are necessary to confirm the prognostic impact of this valvulopathy and the possible benefit of aortic valve replacement.
Prognostic role of tricuspid annular plane systolic excursion/pulmonary artery systolic pressure ratio in patients hospitalized for acute heart failure
Authors: Bonelli Andrea , Pagnesi Matteo , Inciardi Riccardo Maria , Castiello Assunta , Sciatti Edoardo , Carubelli Valentina , Lombardi Carlo Mario , Metra Marco , Vizzardi Enrico 
Published: July 2023

Background
The role of TAPSE/PASP, a measurement of right ventricular to pulmonary artery coupling, in patients hospitalized for acute heart failure (AHF) is poorly described.

Objectives
To evaluate the prognostic impact of TAPSE/PASP in AHF.

Methods
This retrospective single-center study included patients hospitalized for AHF between January 2004 and May 2017. TAPSE/PASP was evaluated as a continuous variable and as tertiles according to its value on admission. The main outcome was the composite of 1-year all-cause death or heart failure hospitalization.

Results
A total of 340 patients were included [mean age 68.8 ± 11.8 years; 76.2% men, mean left ventricular ejection fraction (LVEF) 30.4 ± 13.3%]. Patients with lower TAPSE/PASP had more comorbidities and a more advanced clinical profile, and received higher doses of intravenous furosemide in the first 24 h. There was a significant, linear, inverse relationship between TAPSE/PASP values and the incidence of the main outcome (P = 0.003). In two multivariable analyses including clinical (model 1), biochemical and imaging parameters (model 2) TAPSE/PASP ratio was independently associated with the primary end point [model 1: hazard ratio 0.813, 95% confidence interval (CI) 0.708–0.932, P = 0.003; model 2: hazard ratio 0.879, 95% CI 0.775–0.996, P = 0.043]. Patients with TAPSE/PASP greater than 0.47 mm/mmHg had a significantly lower risk of the primary end point (model 1: hazard ratio 0.473, 95% CI 0.277–0.808, P = 0.006; model 2: hazard ratio 0.582, 95% CI 0.355–0.955, P = 0.032; both compared with TAPSE/PASP <0.34 mm/mmHg). Similar findings were observed for 1-year all-cause mortality.

Conclusion
TAPSE/PASP on admission demonstrated a prognostic value among patients with AHF.
Porcine bioprostheses for surgical aortic valve replacement: very long-term performance of a third-generation device
Authors: Anselmi Amedeo , Tomasi Jacques , Aymami Marie , Mancini Julien , Nesseler Nicolas , Langanay Thierry , Flecher Erwan , Verhoye Jean-Philippe 
Published: July 2023

Aims
We aimed at investigating the long-term durability of the Epic bioprosthesis for surgical aortic valve replacement (SAVR) in a single-centre series of 888 implantations (2001–2018), expanding previous evaluations with shorter follow-up.

Methods
We retrieved prospectively collected in-hospital data and performed a systematic follow-up focusing on valve-related events (SVD, structural valve deterioration; PPM, patient–prosthesis mismatch; reoperation) (competing risks, CIF and Kaplan--Meier methods). We distinguished between SVD (permanent changes in valve function due to evolutive structural deterioration, ≥10 mmHg average gradient vs. reference echocardiography) and PPM.

Results
Average age at SAVR was 75.4 ± 7 years; 855 (96.3%) bioprostheses entered the follow-up and 396 (46.4%) were alive at last assessment. Follow-up was 99.9% complete, median duration was 7.7 years (entire cohort) and 9.9 years (survivors). At 10 years, overall survival was 50% ± 1.9, freedom from SVD was 99.4% ± 0.3 (competing risks) (seven SVD events after 8.1 ± 4.3 years). Freedom from SVD at 15 years was 98.4% ± 0.8 (competing risks). Prevalence of severe PPM was higher in 19 mm (6.5%) and 21 mm (10.2%) size cohorts. PPM (severe or moderate/severe) had no significant impact on overall survival (log-rank P = 0.27 and P = 0.21, respectively). Freedom from any reintervention (reoperation or TAVI Valve-in-Valve) for SVD at 10 years was 99.4% ± 0.3 (competing risks); freedom from any valve-related reintervention was 97.4% ± 0.6 (competing risks).

Conclusion
The Epic bioprosthesis for SAVR is limited by nonnegligible rates of PPM, which have nonetheless no impact on late survival. This device shows excellent durability and low rates of adverse valve-related events.
Trends in age- and sex-specific atrial fibrillation/flutter mortality in Italy between 2003 and 2017
Authors: Zuin Marco , Malagù Michele , Vitali Francesco , De Raffele Martina , Balla Cristina , Bertini Matteo 
Published: July 2023

Aims
We sought to assess the atrial fibrillation/flutter (AF/AFL) mortality rates and relative trends among the Italian population between 2003 and 2017.

Methods
Data regarding the cause-specific mortality and population size by sex in 5-year age groups were extracted from the World Health Organization (WHO) global mortality database. Decedents reporting the codes I48 were extracted accordingly to the International Classification of Disease-10 (ICD-10) coding system. The age-adjusted mortality rates (AAMRs), with relative 95% confidence intervals (CIs), also stratified by sex, were determined using the direct method. Joinpoint regression analyses were used to identify periods with statistically distinct log linear trends in AF/AFL-related death rates. To calculate nationwide annual trends in AF/AFL-related mortality, we assessed the average annual percentage change (AAPC) and relative 95% CIs.

Results
Over the study period, 90 623 (57 109 females) AF-related deaths were recorded. The AF/AFL AAMR increased from 8.1 (95% CI: 7.8–8.2) deaths per 100 000 to 18.7 (16.9–20.0) deaths per 100 000 population. Joinpoint regression analysis revealed a linear increase in age-standardized AF/AFL-related mortality [AAPC: +3.6 (95% CI: 3.0–4.3, P < 0.0001)] in the entire Italian population. Moreover, the mortality rate increased with age, showing a seemingly exponential distribution with a similar trend between males and females. Although the increase was more pronounced among women [AAPC: +3.7 (95% CI: 3.1–4.3, P < 0.0001)] compared with men [AAPC: +3.4 (95% CI: 2.8–4.0, P < 0.0001)], the difference did not reach statistical significance (P = 0.16).

Conclusions
In Italy, the AF/AFL-related mortality rates linearly increased from 2003 to 2017.
Longitudinal analysis of pump parameters over long-term support with the HeartMate 3 left ventricular assist device
Authors: Consolo Filippo , Pieri Marina , Pazzanese Vittorio , Scandroglio Anna Mara , Pappalardo Federico 
Published: July 2023

Aims
Recurrence of heart failure emerged as the main cause of long-term mortality in patients implanted with the HeartMate 3 (HM3) left ventricular assist device (LVAD). We aimed at deriving a possible mechanistic rationale of clinical outcomes and analyzed longitudinal changes in pump parameters over prolonged HM3 support to investigate long-term effects of pump settings on left ventricular mechanics.

Methods
Data on pump parameters (i.e. pump speed, estimated flow, and pulsatility index) were prospectively recorded in consecutive HM3 patients following postoperative rehabilitation (baseline) and then at 6, 12, 24, 36, 48, and 60 months of support.

Results
Data of 43 consecutive patients were analyzed. Pump parameters were set according to regular patients’ follow-up, including clinical and echocardiographic assessment. We recorded a significant progressive increase in pump speed over the course of support: from 5200 (5050–5300) rpm at baseline to 5400 (5300–5600) rpm at 60 months of support (P = 0.0007). Consistently with the increase in pump speed, a significant increase in pump flow (P = 0.007) and a decrease in pulsatility index (P = 0.005) were also recorded.

Conclusion
Our results reveal unique features of the HM3 on left ventricular activity. The need for progressive increase in pump support suggests indeed a lack of recovery and worsening of left ventricular function, which emerge as a possible mechanistic rationale of heart failure related mortality in HM3 patients. New algorithms to optimize pump settings should be envisioned to further improve LVAD-LV interaction and, ultimately, clinical outcomes in the HM3 population.

Clinical Trial Registration

https://clinicaltrials.gov/ct2/show/NCT03255928

ClinicalTrials.gov Identifier
NCT03255928
SISTEM INFORMASI PENERIMAAN SISWA BARU BERBASIS WEB DI SMK KHAMAS ASEMBAGUS MENGGUNAKAN PHP
Authors: Santoso Firman , Wilda Sufil , Fatah Zaehol 
Published: July 2023

Penerimaan peserta didik baru (PPDB) Online adalah sebuah sistem yang dirancang untuk melakukan seleksi otomatis mulai dari pendaftaran, peroses seleksi hingga proses pengumuman seleksi. Sistem PPDB online ini diharapkan mampu memenuhi harapan masyarakat tentang implementasi penerimaan peserta didik baru yang objektif, transparan dan akuntabel. Penelitian ini dilakukan untuk mendeskripsikan manajemen penerimaan peserta didik baru online jenjang SMK Khamas Asembagus Situbondo, meliputi perencanaan, pengorganisasian, pelaksanaan, pengendalian, faktor-faktor penunjang keberhasilan dan faktor penghambatnya. Penelitian ini dilatarbelakangi oleh permasalahan dalam pelaksanaan penerimaan peserta didik baru SMK Khamas Asembagus yang masih dilaksanakan dengan cara mendftarkan menggunakan formulir ketras yang diberikan kepada calon peserta didik baru sehingga memakan waktu yang lama. Metode yang digunakan dalam penelitian ini adalah (1) metode kualitatif pendekatan deskriptif, (2) lokasi penelitian dilaksanakan di SMK Khamas asembagus Situbondo, (3) sumber data informan tim PPDB online, (4) teknik pengumpulan data yang dilakukan adalah wawancara. Berdasarkan hasil penelitian, (1) Perencanaan PPDB Online meliputi pembentukan panitia, pelaksanaan, pembuatan website, (2) Pelaksanaan PPDB online berdasarkan petunjuk pelaksanaan yang tercantum dalam peraturan Sekolah yang meliputi pendaftaran, seleksi sampai pendaftaran ulang. (3) Pengendalian dilakukan melalui pengawasann oleh tim pengawasan dan pengaduan serta evaluasi yang dilakukan oleh tim PPDB tingkat kota dan sekolah. (4) Faktor-faktor penununjang keberhasilan PPDB online terdiri dari kejasama antar panitia. (5) Faktor penghambat terdiri dari SDM, keterbatasan infrastruktur, serta pemahaman terhadap teknologi.
Uma análise econômica da regulamentação dos security tokens no Brasil
Authors: Yeung Luk Tai , Barreto Mesiano Savastano Bruno 
Published: July 2023

A regulamentação dos ativos digitais é um assunto controverso em todos as jurisdições, principalmente devido ao que parece ser uma impressão geral de que a regulamentação e os ativos digitais são temas contraditórios e, como tais, devem permanecer apartados. Este artigo apresenta três objetivos. Em primeiro lugar, traremos à luz parte da literatura recente sobre regulamentação de ativos digitais, desde uma análise da experiência internacional, passando a considerações sobre o conceito de ativos digitais e, posteriormente, a uma análise empírica dos efeitos da regulamentação dos mercados dos ativos digitais. Em segundo lugar, empenharemos em entender a natureza e a definição de ativos digitais, tanto internacionalmente quanto localmente. Por fim, elaboraremos uma teoria de como a Comissão de Valores Mobiliários (CVM) poderia encontrar uma estratégia ideal para regulamentar tais ativos, usando uma perspectiva de "Law & Economics" (Análise Econômica do Direito), mais precisamente através do emprego do conceitual da teoria dos jogos.
Necessidade e condições de próteses dentárias e seu impacto na qualidade de vida de idosos institucionalizados
Authors: Estrella Rafaela Caminha de Souza , Elias Othavio Cesino , Lima Vinícius Augusto Serra de , Soares Diego Moura , Araújo Carla Adriane Fonseca Leal de , Carvalho Amanda Pacheco de , Silva Thaís Carine Lisboa da 
Published: July 2023

Objetivo: Identificar a necessidade de prótese e avaliar as condições daquelas já instaladas associando com a qualidade de vida em um grupo de idosos institucionalizados. Métodos: A caracterização foi realizada através do questionário sociodemográfico e para identificar a necessidade de prótese foram utilizados os critérios do SBBRASIL (2010). Para avaliar as condições das próteses instaladas adotou-se os critérios de retenção e estética. A qualidade de vida foi analisada aplicando o questionário GOHAI. A comparação dos percentuais foi feita pelo teste Qui-quadrado. Resultados: Dos 70 idosos avaliados, 98,6% necessitam de prótese, destes 65,2% de prótese total bi-maxilar. A maioria dos idosos usuários de prótese (p = 0,033), apresentou o nível baixo de qualidade de vida, sendo mais prevalente no grupo de pacientes do sexo feminino, com idade de 60 a 80 anos, da cor preta, do interior do estado de PE, casado ou em união estável, com 5 ou mais filhos, analfabeto, com menos de 1 ano de internamento na instituição de longa permanência. Conclusão: Estudo evidenciou a alta necessidade de prótese e de assistência odontológica aos idosos institucionalizados, com foco na reabilitação oral para melhora da qualidade de vida.
INFLUENCE OF THIRAM ON THE STATE OF THE GLUTATHIONE REDOX SYSTEM OF THE BODY
Authors: Королев В.А. , Седых А.В. , Потенко В.В. , Фелькер Е.В. , Ячменева Л.А. , Королев Е.В. 
Published: July 2023

Пищевая интоксикация фунгицидным препаратом тирам, может приводить к развитию хронического токсического окислительного стресса и, как следствие, активации процессов свободнорадикального окисления, дисбалансу антиоксидантной системы, в частности глутатионового семейства. Цель исследования: Изучение влияния тирама на состояние глутатионовой редокс-системы организма. Исследована роль системы антиоксидантной защиты при окислительном стрессе, вызванным интоксикацией тирамом при воздействии in vivo на организм крыс. Проанализированы каталитическая активность ферментов глутатионового семейства – глутатионредуктазы (GSR), глутатионтрасферазы (GST), глутатионпероксидазы (GPx) и подфракций глутатиона (GSH и GSSG). Моделирование субхронической интоксикации привело к увеличению активности GSR, GST и GPx. В тоже время моделирование субхронической интоксикации крыс тирамом, привело к снижению содержания восставленного глутатиона и увеличению окисленного во всех проанализированных биологических средах. Применение фунгицида тирам приводит к развитию окислительного стресса, что выражается в усилении образования свободных радикалов и накоплении GSSG.
Food intoxication with the fungicidal drug thiram can lead to the development of chronic toxic oxidative stress and, as a result, activation of free radical oxidation processes, imbalance of the antioxidant system, in particular the glutathione family. The purpose of the study: To study the effect of thiram on the state of the glutathione redox system of the body. The role of the antioxidant defense system in oxidative stress caused by thiram intoxication was studied when exposed to rats in vivo. The catalytic activity of glutathione family enzymes, glutathione reductase (GSR), glutathione transferase (GST), glutathione peroxidase (GPx), and glutathione subfractions (GSH and GSSG), was analyzed. Modeling of subchronic intoxication led to an increase in the activity of GSR, GST and GPx. At the same time, modeling of subchronic intoxication of rats with thiram led to a decrease in the content of reduced glutathione and an increase in oxidized glutathione in all analyzed biological media. The use of the fungicide thiram leads to the development of oxidative stress, which is expressed in increased formation of free radicals and accumulation of GSSG.
RECONSTRUCTION OF NOISE PROTECTIVE CONSTRUCTIONS TO IMPROVE THE VIDEO-ECOLOGICAL SPACE ON THE EXAMPLE OF THE CITY OF MOSCOW
Authors: Мамина Д.Х. , Ермилов Н.А. 
Published: July 2023

В статье анализируются возможности реконструкции шумозащитных экранов для улучшения видеоэкологических свойств урбанизированных территорий
The article considers video-environmental solutions for the design of noise screens, which can reduce noise pollution in urban areas
DEVELOPMENT OF AN LED IRRADIATOR FOR GROWING VEGETABLE PLANTS USING LIGHT-CULTURE TECHNOLOGY
Authors: Железникова О.Е. , Микаева С.А. , Чмиль К.А. , Горбунова А.Д. 
Published: July 2023

Статья посвящена разработке и созданию светодиодной облучательной установки (СОУ) с физиологически обоснованным регулированием спектрального состава излучения. СОУ предназначена для выращивания овощных и зеленных культур в сооружениях защищенного грунта с возможностью адаптации режима облучения под потребности конкретной культуры и позволяет увеличить спектральный диапазон излучения за счет использования белых светодиодов.
The article is devoted to the development and creation of LED irradiation unit (IUU) with physiologically justified regulation of the spectral composition of radiation. The irradiation system is designed for growing vegetable and green crops in greenhouses with the possibility of adapting the irradiation mode to the needs of a particular crop and allows you to increase the spectral range of radiation through the use of white LEDs.
DESIGN OF COMPRESSED METAL Z-SHAPED STIFFENED PANELS UNDER STABILITY LIMITATIONS AND CONSIDERING THE EFFECT OF THROUGH DAMAGE
Authors: Митрофанов О.В. , Торопылина Е.Ю. 
Published: July 2023

Предложена уточненная аналитическая методика проектирования сжатых подкрепленных металлических панелей, основанная на условии равноустойчивости, и модифицированная за счет учета сквозных повреждений в обшивке. Проведены параметрических исследований влияния расположения сквозного отверстия на критические напряжения обшивки при сжатии.
The paper proposes analytical techniques for designing stiffened metal panels the use of the condition of uniform stability and modified by taking into account through damage in the skin. Parametric studies of the effect of the location of the through hole on the critical stresses of the skin during compression have been carried out.
Dominasi Musik Barat pada Ujian Tugas Akhir Mahasiswa Prodi Angklung dan Musik Bambu
Authors: Christiana Whayan 
Published: July 2023

Abstrak
Penelitian ini bermaksud untuk mengungkapkan dikotomi antara musik diatonis dan pentatonis
yang ada di Program Studi Angklung dan Musik Bambu Institut Seni Budaya Indonesia Bandung.
Penelitian ini mencoba menemukan akar masalah pada mahasiswa dan untuk menemukan
hubungan antara pengalaman dan minat mereka pada musik barat yang mendominasi
pertunjukan dalam membuat karya ujian tugas akhir. Penelitian ini juga mencoba melihat
masalah lain yang muncul seperti masalah sarana dan prasarana yang ada di Prodi Bambu.
Penelitian ini dilakukan dengan menggunakan teknik pengumpulan data sebagai data lapangan,
dan telah dilakukan dengan menggunakan pendekatan fenomenologis. Sesuai dengan prinsip
metode kualitatif, penelitian ini akan memberikan data secara ilmiah. Pada realitanya, hanya
sedikit dari mahasiswa yang tertarik pada musik tradisional untuk materi ujian tugas akhir.
Berdasarkan penelitian ini, maka kita akan tahu bahwa faktor lingkungan mahasiswa sebelum
mereka memasuki ISBI dan lingkungan setelah masuk ISBI akan menjadi faktor utama dalam
memilih minat. Jenis musik pentatonik yang tidak akrab di telinga mereka, mata pelajaran
tradisional yang selalu monoton dan membosankan, menjadi salah satu alasan mahasiswa untuk
“menghindari” musik pentatonis. Konklusi penelitian ini menggaris bawahi bahwa penelitian ini
bukan tentang materi mata kuliah, tetapi para dosen. Kritik utama adalah tentang kemampuan
dosen musik tradisional dalam memberikan metode pembelajaran untuk memompa semangat
para mahasiswa. Hal ini dikarenakan jaman sekarang berbeda dengan jaman dulu yang artinya
musik itu harus dinamis berubah sesuai dengan perkembangan jaman. Diharapkan dengan
metode yang tepat akan memenuhi tujuan kurikulum yang menguatkan kreativitas
pengembangan seni tradisi.
Kata kunci: Dominasi, Musik Diatonis, Lingkungan