bluuebunny/crossref_metadata_2025_split huggingface dataset:
Premarital screening of the viral hepatitis among Saudi nationals
Authors: Alzahrani Abdullah A. K. , Altalhi Yasser A. , Alghamdi Ahmed A. S. , Muhandis Samah M. , Al Aboud Daifallah M. , Shehab Gaber M. G. , Abdel‐Moneim Ahmed S. 
Published: February 2023

AbstractBlood borne sexually transmitted infections are among the most serious health problems worldwide. Many people possessing these infections do not have symptoms and may remain undiagnosed. The current study aimed to screen premaritally the incidence of blood borne viruses among Saudi nationals. A retrospective longitudinal study was conducted, using a total of 91,000 medical records, in the blood bank from a single center in the Western region of Saudi Arabia. All persons who underwent premarital examination during the period 2016–2021 for the presence of hepatitis B and C viruses as a part of the national screening program in Saudi Arabia were included in the study. Serological tests were used to screen the presence of HBc Ab and HBs Ag. Both anti‐HCV antibodies and the presence of virus RNA using real‐time reverse transcriptase polymerase chain reaction (RT‐PCR) were also performed. The study reported the presence of 378/91000 (0.42%) infections with hepatitis B virus (HBV) as indicated by the presence of HBc Ab and HBs Ag. Meanwhile, 208 (0.23%) cases were found to be exposed to HCV including 49/91000 (0.05%) active HCV cases, positive for the HCV RNA, while 159/91000 (0.17%) persons were found to possess positive HCV antibodies in the absence of detectable HCV RNA. It was concluded that there is a low prevalence of HBV and HBV among Saudi citizens who were subjected to premarital screening.
Development and validation of a food‐related analysis–holism scale (F‐AHS)
Authors: Beekman Thadeus L. , Seo Han‐Seok 
Published: February 2023

AbstractRecent studies have indicated analytic–holistic cognitive style differences of consumers can significantly impact perceptions, opinions, and behaviors toward foods. Interestingly, these studies have also offered evidence that the sole measurement tool to assess analytic–holistic tendencies, the analysis–holism scale (AHS), may not accurately apply to food‐experience‐related research scenarios. Due to these notions, Studies 1 and 2 employed the use of 465 and 487 participants, respectively, to develop, refine, and finalize a food‐related AHS (F‐AHS) using exploratory and confirmatory factor analyses and prior research on analytic–holistic differences and scale development. Study 3 was conducted to validate the newly developed F‐AHS, based on the results of Studies 1 and 2, by replicating the procedures and analyses from prior research while using the F‐AHS instead of the AHS to segment participants (N = 130). The results of Study 3 provided consistent evidence that the F‐AHS better separated participants into analytic and holistic groups than the AHS through larger analytic–holistic differences that more closely aligned with prior analytic–holistic research. Our findings showed that the F‐AHS is capable of separating consumers into analytic and holistic cognitive style groups and is better suited to sensory and consumer‐related applications than the AHS.Practical ApplicationOur findings provide researchers with an optimized tool to separate consumers into analytic and holistic groups in food‐experience‐related situations. The food‐related analysis–holism scale can then be used in both academia and industry to separate consumers based on cognitive style to better understand how and why consumers show variations in perception, acceptance, and behavior in food‐related experiences.
SPATA2 suppresses epithelial‐mesenchymal transition to inhibit metastasis and radiotherapy sensitivity in non–small cell lung cancer via impairing DVL1/β‐catenin signaling
Authors: Ji Hongbo , Zhang Lu , Zou Man , Sun Yanchen , Dong Xiaohan , Mi Zeyun , Meng Maobin , Yuan Zhiyong , Wu Zhiqiang 
Published: February 2023

AbstractMetastasis is the major cause of cancer‐related death of cancer patients. Epithelial‐mesenchymal transition (EMT) is one critical process during the cascade of tumor metastasis. EMT is a developmental program exploited by cancer cells to transition from epithelial state to mesenchymal state and confers metastatic properties as well as treatment resistance. Finding factors to inhibit EMT will greatly improve the prognosis patients. Spermatogenesis associated 2 (SPATA2) was originally isolated from human testis and proved playing a role in spermatogenesis. To date, however, the role of SPATA2 in oncogenesis is unknown. In the current study, by mining the public database and validating in a cohort of collected non–small cell lung cancer (NSCLC) specimens, we uncovered that the expression of SPATA2 positively correlated with the prognosis of patients and was an independent prognosis marker in NSCLC. Functional studies proved that ectopic overexpression of SPATA2 inhibited EMT resulting in impaired motility and invasiveness properties in vitro and metastasis in vivo, and increased radiosensitivity in NSCLC. Mechanistic investigation showed that SPATA2 could suppress the β‐catenin signaling via attenuating DVL1 ubiquitination to achieve the functions. Taken together, the current study revealed an inhibitory role of SPATA2 on EMT and that SPATA2 could be a potential target for therapy of NSCLC.
Estimated reimbursement impact of COVID‐19 on emergency physicians
Authors: Venkatesh Arjun K. , Janke Alexander T. , Koski‐Vacirca Ryan , Rothenberg Craig , Parwani Vivek , Granovsky Mike A. , Burke Laura G. , Li Shu‐Xia , Pines Jesse M. 
Published: February 2023

AbstractBackgroundThe delivery and financing of health care services were altered in unprecedented ways by COVID‐19 and subsequent policy responses. We estimated reimbursement losses to emergency physicians in 2020 compared to 2019 related to shifting acute care utilization during COVID‐19.MethodsThis was an observational analysis of the Clinical Emergency Department Registry (CEDR) and the Nationwide Emergency Department Sample (NEDS). Study sample included all ED visits from a sample of 214 emergency department (ED) sites in the CEDR in 2019 and 2020 as well as all ED visits in the NEDS in 2019. We identified level of service billing code for evaluation and management (E&M) services, insurance payer, and geographic location of ED visits across sites in the CEDR and linked these to fee schedules to estimate total professional reimbursement across sites. Our primary analysis was to estimate reimbursement in 2020 compared to 2019 across the CEDR sites. In our secondary analysis, we linked sites in the CEDR to those in NEDS to estimate nationwide reimbursement.ResultsTotal E&M reimbursement for emergency physicians in the CEDR was $1.6 billion in 2019 and $1.3 billion in 2020, reflecting a 19.7% decline year over year ($308 million loss). In our secondary analysis, we estimate nationwide losses of $6.6 billion, a −19.4% decline year over year. If emergency physicians had received maximum allowable federal relief funds via CARES Act Phases 1 to 3 (2% of 2019 revenue) this would sum to $680 million (2% of the $34 billion) or 10.3% of the estimated $6.6 billion pandemic‐related losses.ConclusionsOur analyses provide an estimate of the scale of economic impacts of the COVID‐19 pandemic. These findings warrant consideration for policymaker relief and future redesign of emergency care financing. Ultimately, the COVID‐19 pandemic likely expanded known cracks in the financing of health care into steep fault lines.
The link between formality and procedural fairness: The influences of precision, sensitivity and role clarity
Authors: Wang Kelly K. , Dyball Maria Cadiz , Wang Andy 
Published: February 2023

AbstractThis study investigates the complex and not straight‐forward association between formality and procedural fairness. It examines the mediating roles of precision of performance measures, sensitivity of performance measures and role clarity. Using survey responses of functional managers of Australian manufacturing firms, the study finds that the link between formality and procedural fairness is mediated by sensitivity of performance measures and role clarity. Role clarity also mediates the link between sensitivity of performance measures and procedural fairness. Our study contributes to the literature by identifying two important factors through which formal performance evaluation can enhance procedural fairness, which is a source of performance motivation.
Distributional heterogeneity in climate change impacts and adaptation: Evidence from Indian agriculture
Authors: Kumar Surender , Khanna Madhu 
Published: February 2023

AbstractThis study estimates the distributional heterogeneity in the effects of climate change on yields of three major cereal crops: rice, maize, and wheat in India using district‐level information for the period 1966–2015. We distinguish between the effects of changes in growing season weather from those due to changes in long‐term climate trends and the heterogeneity in these effects across the distribution of crop yields by estimating naïve and climate penalty inclusive models using fixed‐effect quantile panel models. We observe an absence of adaptation against rising temperatures for rice and wheat. However, we find a statistically significant presence of adaptation for wheat and maize for changes in precipitation, though the magnitude is small. Moreover, we find that the effects are asymmetric, and are larger at the lower tail of productivity distribution and smaller at the upper tail of the distribution. A 1°C increase in temperature lowers rice and wheat productivity by 23% and 9%, respectively at the first quantile, but the damage is only 6% and 5% at the ninth quantile. Heterogeneity in impacts and adaptation estimates over the yield distribution curve and across crops suggests the importance of customizing strategies for adaptation to changing weather and climate conditions across regions, crops, and current productivity levels.
Evaluating the tradeoff between cost effectiveness and participation in agricultural conservation programs
Authors: Howard Gregory , Zhang Wendong , Valcu‐Lisman Adriana , Gassman Philip W. 
Published: February 2023

AbstractUsing a survey of 430 farmer respondents in the Boone and North Raccoon River watersheds in Iowa, we examine the impacts of three program innovations—reverse auctions, spatially targeted payments, and higher offered payments—on agricultural conservation program cost effectiveness and participation by farmers. We combine farmer responses to a discrete choice experiment offering voluntary conservation contracts with township‐level estimates of per‐acre nitrogen reductions from each practice derived from the process‐based ecohydrological Soil and Water Assessment Tool model. Using a random‐parameters logit model, we show that both cost‐reducing and benefit‐boosting interventions reduce budgetary costs per projected pound of nitrogen removed from the watershed for each practice and thus are more cost effective than the prevailing current cost‐share programs. However, we find that these interventions can reduce participation by 30%–70%. Our policy simulations show that even with large budgets, the watershed‐level nitrogen reduction from all policy interventions remains far below the policy targets set by the Iowa Nutrient Reduction Strategy. Furthermore, we find cover crop contracts are far more cost effective than no‐till/strip‐till split nitrogen application contracts.
A molecular sensitization map of European children reveals exposome‐ and climate‐dependent sensitization profiles
Authors: Kiewiet M. B. Gea , Lupinek Christian , Vrtala Susanne , Wieser Sandra , Baar Alexandra , Kiss Renata , Kull Inger , Melén Erik , Wickman Magnus , Porta Daniela , Gori Davide , Gehring Ulrike , Aalberse Rob , Sunyer Jordi , Standl Marie , Heinrich Joachim , Waiblinger Dagmar , Wright John , Antó Josep M. , Bousquet Jean , van Hage Marianne , Valenta Rudolf 
Published: February 2023

AbstractBackgroundUnderstanding differences in sensitization profiles at the molecular allergen level is important for diagnosis, personalized treatment and prevention strategies in allergy.MethodsImmunoglobulin E (IgE) sensitization profiles were determined in more than 2800 sera from children in nine population‐based cohorts in different geographical regions of Europe; north [BAMSE (Sweden), ECA (Norway)], west/central [PIAMA (the Netherlands), BiB (the United Kingdom), GINIplus (Germany)], and south [INMA Sabadell and Gipuzkoa (Spain) and ROBBIC Rome and Bologna (Italy)] using the MeDALL‐allergen chip.ResultsSensitization to grass pollen allergen, Phl p 1, and to major cat allergen, Fel d 1, dominated in most European regions whereas sensitization to house dust mite allergens Der p 1, 2 and 23 varied considerably between regions and were lowest in the north. Less than half of children from Sabadell which has a hot and dry climate were sensitized to respiratory allergens, in particular house dust mite allergens as compared to Gipuzkoa nearby with a more humid climate. Peanut allergen Ara h 1 was the most frequently recognized class 1 food allergen in Northern/Western Europe, while the fruit allergens Pru p 3, Act d 1 and 2 were prominent in Southern and Western/Central Europe. Ves v 5‐sensitization dominated in North and West/Central Europe.ConclusionWe show regional, exposome‐ and climate‐dependent differences in molecular IgE‐reactivity profiles in Northern, Western/Central and Southern Europe which may form a molecular basis for precision medicine‐based approaches for treatment and prevention of allergy.
All‐cause and cardiovascular mortality after hysterectomy and oophorectomy in a large cohort (HUNT2)
Authors: Michelsen Trond M. , Rosland Tina Ellinor , Åsvold Bjørn O. , Pripp Are H. , Liavaag Astrid H. , Johansen Nora 
Published: February 2023

AbstractIntroductionHysterectomy and bilateral oophorectomy are common major surgical procedures that have been associated with increased mortality risk. We aimed to assess the association of hysterectomy and/or bilateral oophorectomy with all‐cause and cardiovascular mortality in a Norwegian population.Material and methodsCohort study with data from The Trøndelag Health Study (HUNT2) linked to the Norwegian Cause of Death Registry, with follow‐up from 1996 until 2014 or death. The unexposed group (n = 18 673) included women with both their ovaries and uterus intact, while the two exposed groups included women with hysterectomy alone (n = 1199), or bilateral oophorectomy with or without hysterectomy (n = 907). We compared mortality in exposed vs unexposed groups and adjusted for relevant covariates by Cox regression. Further, we performed analyses stratified by age at surgery (≤39, 40–52, ≥53 years) and subgroup analyses among women ≤52 years of age at inclusion.ResultsAmong the 47 312 women in HUNT2 (1995–1997), 20 779 provided complete information regarding gynecological surgery and previous health. The hysterectomy group had increased all‐cause mortality (hazard ratio [HR] 1.30, 95% confidence interval [CI] 1.06–1.58) and cardiovascular mortality (HR 1.47, 95% CI 1.09–1.97). We found no significant association between bilateral oophorectomy and all‐cause or cardiovascular mortality in the total population. However, among women ≤52 years at inclusion, cardiovascular mortality was increased in the hysterectomy group (HR 2.71, 95% CI 1.19–6.17) with a similar, but less precise estimate in the bilateral oophorectomy group (HR 2.42, 95% CI 0.84–6.93).ConclusionsHysterectomy was associated with increased all‐cause and cardiovascular mortality, whereas bilateral salpingo‐oophorectomy was not. Among women ≤52 years at inclusion, both hysterectomy and bilateral oophorectomy were associated with a twofold increased risk of cardiovascular mortality, but the results were imprecise. Women after hysterectomy and/or bilateral salpingo‐oophorectomy constitute a group with increased cardiovascular mortality that may need closer attention to cardiovascular disease risk from the healthcare system to ensure timely and effective preventive interventions.
Editorial: let's get physical—long‐term benefits of vigorous physical activity in patients with nonalcoholic fatty liver disease
Authors: Heinle J. Westley , Stine Jonathan G. 
Published: February 2023

LINKED CONTENTThis article is linked to Henry et al papers. To view these articles, visit https://doi.org/10.1111/apt.17308 and https://doi.org/10.1111/apt.17349
Editorial: definition of factors associated with poor quality of life in patients with IBS—but where to from here? Authorsʼ reply
Authors: Goodoory Vivek C. , Guthrie Elspeth A. , Ng Cho Ee , Black Christopher J. , Ford Alexander C. 
Published: February 2023

LINKED CONTENTThis article is linked to Goodoory et al papers. To view these articles, visit https://doi.org/10.1111/apt.17356 and https://doi.org/10.1111/apt.17391
Editorial: real‐world evidence of tofacitinib and vedolizumab in ulcerative colitis—are we one step closer to better positioning therapies after anti‐TNF failure? Authors' reply
Authors: Buisson Anthony 
Published: February 2023

LINKED CONTENTThis article is linked to Buisson et al papers. To view these articles, visit https://doi.org/10.1111/apt.17305 and https://doi.org/10.1111/apt.17351
Letter: tricky reactions to switch back from subcutaneous to intravenous vedolizumab in inflammatory bowel disease patients—authors' reply
Authors: Volkers Adriaan , Straatmijer Tessa , Duijvestein Marjolijn , Löwenberg Mark , van der Meulen Andrea , D'Haens Geert 
Published: February 2023

LINKED CONTENTThis article is linked to Volkers et al papers. To view these articles, visit https://doi.org/10.1111/apt.17153 and https://doi.org/10.1111/apt.17395
To behave or not to behave ethically: A question of style?
Authors: Berisha Gentrit , Oliveira Luciana , Humolli Edon 
Published: February 2023

AbstractWhat makes people behave ethically continues to be at the forefront of business ethics research. The stylistic makeup of the decision‐maker has been suspected to influence individual ethical behavior; however, this body of research accounts only for a handful of studies. This paper investigates the influence of decision‐making styles as an individual difference on unethical behavior, independently from other personal characteristics. Covering a sample of 230 managers, we utilize the preeminent measures of these two constructs in a self‐report survey. Our results suggest that the decision‐making styles of managers do influence their ethical behavior. Whereas managers with a dominant rational or spontaneous style behave ethically, having a more intuitive or avoidant makes them behave less ethically. The results also reveal that with higher levels of education, managers become more unethical. This research conveys important implications for management practice, education, and training.
Long‐term excess mortality and net survival among elderly diffuse large B‐cell lymphoma patients after front‐line R‐CHOP treatment
Authors: Belot Aurélien , Camus Vincent , Portugues Cédric , Paget Jérome , Chartier Loic , Cony‐Makhoul Pascale , Tilly Hervé , Joubert Clémentine 
Published: February 2023

SummaryIn the era of immunochemotherapy, data on the long‐term prognosis of elderly patients diagnosed with a diffuse large B‐cell lymphoma (DLBCL) are scarce. In this population and on the longer term, other‐cause mortality is an important competing risk that needs to be accounted for. Using clinical trial data and relative survival approaches, we estimated the 10‐year net survival (NS) and we described the excess mortality hazard (EMH) due (directly or indirectly) to the DLBCL, over time and according to main prognosis factors using flexible regression modelling. The 10‐year NS was 65% [59; 71]. Using the flexible modelling, we showed that the EMH decreases steeply after diagnosis. The variables ‘performance status’, ‘number of extra‐nodal sites’ and the serum ‘lactate dehydrogenase’ were strongly associated with the EMH, even after adjustment on other important variables. EMH is very close to zero at 10 years for the whole population, so DLBCL patients do not experience an increased mortality compared to the general population in the long term. The number of extra‐nodal sites was an important prognostic factor shortly after diagnosis, suggesting that it is correlated with an important but unmeasured prognostic factor that would lead to this selection effect over time.
Search less for a better price
Authors: Bilen Eren , Dizdar Deniz , Miao Chun‐Hui 
Published: February 2023

AbstractIn many markets, sellers must spend resources to learn the costs of providing goods/services. This paper considers consumer searches in such markets. The findings show that: (i) even with ex ante identical consumers and sellers, there is price dispersion in the equilibrium, (ii) despite price dispersion and minimal search costs, it could be optimal to search just two sellers and (iii) the optimal number of searches can increase with sellers' information costs.
Journeys of culturally connecting: Aboriginal young people's experiences of cultural connection in and beyond out‐of‐home care
Authors: Krakouer Jacynta 
Published: February 2023

AbstractWith growing overrepresentation of Aboriginal and Torres Strait Islander children and young people in out‐of‐home care (OOHC), cultural disconnection is an omnipresent threat. Despite research and inquiries that have highlighted the risk of cultural disconnection for Aboriginal and Torres Strait Islander children living in OOHC, limited research has explored Indigenous children and young people's experiences of cultural connection in the Australian context. Informed by Indigenous Standpoint Theory, this Aboriginal‐led qualitative study sought to understand 10 OOHC‐experienced Aboriginal young people's experiences of cultural connection over time, including after exit from OOHC, through retrospective interviews that employed a phenomenological lens. It was found that Aboriginal young people experienced cultural connection as a heterogenous process involving identity formation and the practice of culture, enacted as a choice over time. The complexity of Aboriginal young people's experiences of cultural connection over time gives rise to a new understanding of cultural connection as a journey of culturally connecting, wherein the risk of cultural disconnection is complicated by intergenerational child removals, dominant discourse about what constitutes Aboriginal culture, and removal from an Aboriginal cultural milieu.
Protected area downgrading, downsizing, and degazettement in Cambodia: Enabling conditions and opportunities for intervention
Authors: Nuttall Matthew , Olsson Erik , Washington Harri , Ung Vises , Bunnefeld Nils , Merriman Joel , Griffin Olly , Hobson Keziah , Diment Alex , Kroner Rachel Golden 
Published: February 2023

AbstractProtected area (PA) sustainability is challenged worldwide by legal downgrading, downsizing, and degazettement (PADDD). National and local case studies of ecologically destructive PADDD events provide useful insights that may help respond to or prevent future events. Using information from legal documents and expert input, we identified 37 PADDD events that affected two adjacent PAs in northeastern Cambodia differently despite similar economic, environmental, and social conditions. Important differences in local context led to the eventual degazettement (100% loss) of one PA and downsizing (10.49% loss) of the other, the rest of which remains protected. This case study confirms the contribution of secure Indigenous land tenure to durable conservation governance and demonstrates the importance of investing in site‐level capacity to ensure that social and ecological conditions are monitored and proposed PADDD events can be successfully challenged.