bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of Expression Levels of NFATc2 and PPARG Genes Two Effector Elements of WNT Pathway in Non-Small Cell Lung Carcinoma
Authors: Motamediyan Kaveh , Zafari Venus , Bornehdeli Soghra , Caner Ayşe , Asadi Milad , Hashemzadeh Shahryar , Firozi Mohammad Reza , Raeisi Mortaza 
Published: July 2023

Background:
There is an emergency need in discovering an efficient profile of molecular biomarkers for early diagnosis of Non-small cell lung cancer (NSCLC). Transcription factors as important groups of regulators that are able to adjust the cell cycles have attracted the attention of most researchers recently. NFATc2 and PPARG are two important factors that have been selected for this project to assess their potential for being a biomarker for NSCLC.

Materials and Methods:
Here in this study, 50 NSCLC patients were included. During bronchoscopy, which was their routine diagnostic approach, we collected tumoral and marginal normal tissues. After the extraction of the total RNA from the tissues, cDNA was synthesized, and the transcriptional level of NFATc2 and PPARG was examined by quantitative real-time PCR. Subsequently, the data were analyzed by proper statistical analyses.

Results:
The mRNA expression of NFATc2 and PPARG were down-regulated in biopsy tissues of NSCLC patients compared with their pair marginal tissues (Pvalues were 0.0011 and <0.0001 respectively). Moreover, both of them had significant AUC (area under the curve) in the ROC curve analysis (0.65 for NFATc2 and 0.81 for PPARG, Pvalue <0.05).

Conclusion:
It appears that mRNA expression of NFATc2 and PPARG possesses the potential to be regarded as a diagnostic or prognostic biomarker for NSCLC.
Intra- and interannual changes in isoprene emission from central Amazonia
Authors: Gomes Alves Eliane , Aquino Santana Raoni , Quaresma Dias-Júnior Cléo , Botía Santiago , Taylor Tyeen , Yáñez-Serrano Ana Maria , Kesselmeier Jürgen , Bourtsoukidis Efstratios , Williams Jonathan , Lembo Silveira de Assis Pedro Ivo , Martins Giordane , de Souza Rodrigo , Duvoisin Júnior Sérgio , Guenther Alex , Gu Dasa , Tsokankunku Anywhere , Sörgel Matthias , Nelson Bruce , Pinto Davieliton , Komiya Shujiro , Martins Rosa Diogo , Weber Bettina , Barbosa Cybelli , Robin Michelle , Feeley Kenneth J. , Duque Alvaro , Londoño Lemos Viviana , Contreras Maria Paula , Idarraga Alvaro , López Norberto , Husby Chad , Jestrow Brett , Cely Toro Iván Mauricio 
Published: July 2023

Abstract. Isoprene emissions are a key component in biosphere–atmosphere interactions, and the most significant global source is the Amazon
rainforest. However, intra- and interannual variations in biological and environmental factors that regulate isoprene emission from Amazonia are
not well understood and, thereby, are poorly represented in models. Here, with datasets covering several years of measurements at the Amazon Tall Tower
Observatory (ATTO) in central Amazonia, Brazil, we (1) quantified canopy profiles of isoprene mixing ratios across seasons of normal and anomalous
years and related them to the main drivers of isoprene emission – solar radiation, temperature, and leaf phenology; (2) evaluated the effect of
leaf age on the magnitude of the isoprene emission factor (Es) from different tree species and scaled up to canopy with intra- and
interannual leaf age distribution derived by a phenocam; and (3) adapted the leaf age algorithm from the Model of Emissions of Gases
and Aerosols from Nature (MEGAN) with observed changes in Es
across leaf ages. Our results showed that the variability in isoprene mixing ratios was higher between seasons (max during the dry-to-wet
transition seasons) than between years, with values from the extreme 2015 El Niño year not significantly higher than in normal years. In
addition, model runs considering in situ observations of canopy Es and the modification on the leaf age algorithm with leaf-level
observations of Es presented considerable improvements in the simulated isoprene flux. This shows that MEGAN estimates of isoprene
emission can be improved when biological processes are mechanistically incorporated into the model.
An approach for projecting the timing of abrupt winter Arctic sea ice loss
Authors: Hankel Camille , Tziperman Eli 
Published: July 2023

Abstract. Abrupt and irreversible winter Arctic sea ice loss may occur under anthropogenic warming due to the disappearance of a sea ice equilibrium at a
threshold value of CO2, commonly referred to as a tipping point. Previous work has been unable to conclusively identify whether a tipping
point in winter Arctic sea ice exists because fully coupled climate models are too computationally expensive to run to equilibrium for many
CO2 values. Here, we explore the deviation of sea ice from its equilibrium state under realistic rates of CO2 increase to
demonstrate for the first time how a few time-dependent CO2 experiments can be used to predict the existence and timing of sea ice tipping
points without running the model to steady state. This study highlights the inefficacy of using a single experiment with slow-changing CO2
to discover changes in the sea ice steady state and provides a novel alternate method that can be developed for the identification of tipping
points in realistic climate models.
Divinas Imagens, (Re) existências e Cuidados em Tempos de Pandemia ao Festejar Espírito Santo em São Luís-Maranhão
Authors: Lindoso Gerson Carlos Pereira , Sampaio Fabiola Fernanda Dominici , Coimbra Lucas Vinicius Lima 
Published: July 2023

A proposta de comunicação oral se propõe a refletir a respeito de algumas cosmovisões e cosmopercepções imagéticas dos povos de matriz africana em São Luís-Maranhão a respeito do cruel contexto pandêmico da Covid-19 disseminado em todo o mundo (especialmente em 2020-2021), tomando como pontos reflexivos as alterações e transformações no cotidiano dessas comunidades, a exemplo dos calendários de realização das suas festas e rituais, tendo como foco aqui, a festa do Divino Espírito Santo, além das mobilizações políticas e estratégias de (re)existências e enfrentamentos do vírus. Como metodologia transitaremos de uma perspectiva pós-colonial/ estruturalista ao pensamento decolonial (KRENAK, 2020) dialogando tanto com a Antropologia Visual/ da Imagem/ Etnografia, quanto com a Cultura Popular e a Sociologia. Como instrumentos investigativos, destacamos nossas interlocuções de pesquisa de campo antropológica com algumas casas de Tambor de Mina e Candomblé na cidade- a exemplo da comunidade de matriz africana da Ialorixá Bianca Lopes (festeira do Divino), que nos últimos anos tem realizado a sua festa no Centro Histórico Ludovicense- ‘O Divino no/ do Reviver’. Uma das problemáticas apontadas pelo trabalho elencará quais os sentidos e significados resultantes das imagens de interdição, do silenciamento das caixas e, especialmente das desobediências pandêmicas nas continuidades das devoções sagradas ao Divino Espírito Santo e no ‘fazer festivo’.
Palavras-chave: Divino Espírito Santo, Festas, Pandemia, Covid-19, Reviver.
Terapi Farmakologis pada Pasien Sub Acute Postherpetic Neuralgia: Sebuah Laporan Kasus
Authors: Irwan Alamsyah , Musba Andi Muhammad Takdir 
Published: July 2023

ABSTRAK
Pendahuluan : Herpes zoster disebabkan oleh reaktivasi virus varicella zoster. Post Herpetic Neuralgia (PHN) ialah nyeri akibat zoster yang masih ada 1 bulan setelah perkembangan vesikel. Biasanya prognosisnya baik, namun beberapa pasien tetap menderita nyeri jangka panjang. Tujuan terapi PHN adalah mengurangi nyeri dan meningkatkan kualitas hidup. Obat antiepilepsi dan antidepresan trisiklik adalah pilihan pertama.
Ilustrasi Kasus : Pada laporan kasus ini, dilakukan pengamatan pada pasien laki-laki berusia 32 tahun dengan nyeri kepala sebelah kiri menjalar seperti listrik hingga kelopak mata kiri selama ± 6 minggu, rasa tertusuk-tusuk paku secara tiba-tiba, terasa kebas/kram, terdapat nyeri saat disentuh (allodynia), dan hipoestesia. Riwayat penyakit sebelumnya ialah herpes zoster dan mendapatkan terapi acyclovir dan simpotamis seperti paracetamol, asam mefenamat, dexamethasone, dan cetirizine. Pasien datang dengan Visua Analog Scale (VAS) 6-7/10 dan didiagnosis dengan Sub Acute Post Herpetic Neuralgia. Pasien mendapatkan terapi Lyrica (Pregabalin) 50 mg 2 kali sehari 1 tablet, Amitriptyline 10 mg sekali sehari 1 tablet, Ultracet (Tramadol 37,5 mg + paracetamol 375 mg) 3 kali sehari 1 tablet. Setelah hari ke-14 VAS pasien berkurang menjadi 2/10, namun timbul efek samping berupa bibir kering dan sering ngantuk dan pengobatan yang berlanjut hanya Amitriptyline 10 mg/hari.
Simpulan : Pemberian terapi yang cepat pada PHN memberikan pencegahan terjadinya nyeri yang refrakter, sehingga sulit memberikan terapi yang adekuat. Pemberian terapi lini pertama pada PHN subakut menggunakan agen amitriptyline, pregabalin, dan tramadol memberikan efek yang sangat baik dalam mengatasi nyeri pada subacute PHN, akan tetapi perlu adanya pemantauan tentang efek samping yang terjadi dikarenakan potensiasi pada ketiga obat tersebut.
Kata Kunci : amitriptyline, pregabalin, subacute post herpetic neuralgia, tramadol, visual analog scale
Actualización del Síndrome de tako-tsubo asociado con COVID-19
Authors: Terán Flores Katherine Elizabeth , Garcés Katherine Elizabeth 
Published: July 2023

Introducción: La miocardiopatía de Takotsubo y su asociación con el Covid-19, es un síndrome que se va a caracterizar por un cuadro agudo, donde existe disfunción sistólica regional transitoria del ventrículo izquierdo que corresponde a eventos emocionalmente estresantes o eventos físicos que sean, principalmente afecta a mujeres posmenopáusicas, su mecanismo fisiopatológico aún no se conoce a ciencia cierta, aunque se consideraba que se trataba de un cuadro benigno actualmente se asocia a varias complicaciones. Objetivo: Describir el síndrome de Tako-tsubo y su relación con el Covid-19. Metodología: Este estudio observacional y descriptivo utilizó una investigación de la literatura de la investigación científica la cual cumplió con los criterios de inclusión que se detallan a continuación: que las investigaciones sean realizadas en inglés o español en los últimos 5 años sobre el síndrome de Tako-tsubo y su relación con el Covid-19. Resultados: Se incluyeron 26 artículos, pertinentes y elegibles con el tema del síndrome de tako-tsubo y la relación con el Covid-19. El 99.5% de los pacientes presentaron niveles de troponinas aumentados. Se presentó miocarditis o miopericarditis posterior a recibir la vacuna BNT162 en un 74,4% de los casos. En cuanto a las pruebas cardiacas se evidencio que el electrocardiograma suele ser normal en cerca de 21% de los pacientes. La angiografía coronaria y la ventriculografía son las modalidades de diagnóstico recomendadas, y el manejo debe incluir medidas de soporte y tratamiento de cualquier complicación. Conclusión: El síndrome de tako-tsubo en pacientes que presenten Covid -19 es muy raro, sin embargo, de presentarse puede llevar a una gran morbimortalidad.
Pemanfaatan Teknologi Penginderaan Jauh dan Sistem Informasi Geografis untuk Identifikasi Perubahan Tutupan Lahan di DAS Marikurubu, Kota Ternate
Authors: Manakane Susan E. , Rakuasa Heinrich , Latue Philia Christi 
Published: July 2023

Pertambahan jumlah penduduk yang semakin meningkat, tentunya berpengaruh terhadap kebutuhan dan ketersedian lahan di DAS Marikurubu, Kota Ternate. Dengan memanfaatkan teknologi penginderaan jauh dan sistim infomasi geografis kita dapat mengidentifikasi dan menganalsis perubahan tutupan lahan di DAS Marikurubu dengan menggunakan data citra satelit. Penelitian ini menggunakan data citra satelit Landsat 4-5 TM C2 L2 tahun 2003 untuk analisisi tutupan lahan tahun 2003, dan Landsat 8-9 OLI/TIRS C2 L2 tahun 2013 untuk analisisi tutupan lahan tahun 2013 dan 2023 dengan mengacu pada standar klasifikasi tutupan lahan berdasarkan SNI-2010 yang dilakukan dengan interpertasi dan digitasi yang dilakukakn secara visiual di software Arc GIS 10.8. Hasil penelitian menunjukan bahwa lahan terbangun di DAS Marikurubu, Kota Ternate mengalami pertambahan luasan pada periode 2003-2013-2023. Pada tahun 2003 memiliki prsentase luasan sebesar 44, 58%, tahun 2013 sebesar 49,60% dan pada tahun 2023 sebesar 51,74% dari total luasan di DAS Marikurubu. Hal ini tentunya berbeda dengan kelas tutupan lahan lainnya yang mengalami penurunan luasan. Hasil penelitian diharapkan dapat menjadi informasi bagi pemerintah dan masyarakat dalam upaya penataan ruang kedepannya di Daerah Aliran sungai (DAS) Marikurubu, Kota Ternate kedepannya.
Poetry Writing Skills for Grade IV SDIT ALIF Students Using the Acrostic Technique
Authors: Wijayanti Ika 
Published: July 2023

Background: The ability to write is a human effort to express thoughts and emotions contained in written language. Writing poetry is a productive activity and the ability to write poetry can be achieved through systematic teaching and intensive training. Learning poetry provides many benefits for students. Students can express themselves and expand their vocabulary. In addition, students know how to use language to understand, develop, and convey ideas and information to readers. Purpose: The purpose of this study was to determine the poetry writing skills of fourth-grade students at SDIT ALIF after using the acrostic technique. Design and methods: This research was compiled using a descriptive method based on analysis guidelines through a qualitative approach. Qualitative descriptive is the term used in qualitative research for descriptive research. The researcher's analysis technique uses observation and document analysis. Results: This study shows that the results of the analysis of the poetry writing skills of fourth grade students at SDIT ALIF with the acrostic technique are students who match the skills of writing acrostic poetry by 75%. Students who do not fit the skills of writing acrostic poetry 25%. Conclusion (1) From the results of the analysis of the Poetry Writing Skills of Grade IV Students at SDIT ALIF using the acrostic technique, it was found that 75% of the 61 samples fit the skills of writing acrostic poetry. In the activity of writing poetry, class IV SDIT ALIF students using the acrostic technique carried out quite well, but there were some students who were still lacking in writing acrostic poetry, such as the discrepancy between the word patterns written vertically and the suitability of the content. and title and unable to express ideas. his thoughts into poetry. (2) This research was said to be quite successful because 75% of the 60 samples of poetry written by children were able to express their ideas, experiences, thoughts, expressions, and imagination into well-structured writing so as to give a good impression. readers' ideas about the meaning or message of the posts that have been written
Sistema constructivo de paneles aligerados con poliestireno expandido y malla electrosoldada espacial: estudio estructural y optimización
Authors:   , Cansario Pérez Maria del Mar 
Published: July 2023

Los sistemas modernos de construcción son asociados a tecnologías innovadoras y a los nuevos materiales, sistemas livianos que ofrecen la posibilidad de una mayor rapidez de ejecución por montaje. Estas características influyen en gran medida en el aprovechamiento de los materiales y de la mano de obra, ya que la planificación se hace más sencilla, pudiendo cumplir las metas fijadas en cuanto a los recursos económicos y de tiempo. La demanda de mayor cantidad de viviendas hace necesaria la inversión en investigación para considerar nuevas opciones y encontrar soluciones técnicas apropiadas, esto ha provocado un alto grado de especialización, principalmente en el campo de la ingeniería.<br/><br/>	Los sistemas constructivos convencionales han evolucionado de acuerdo a nuevos criterios para el análisis, desarrollo de procesos y puesta en obra. De esta manera aumenta su utilización, ofreciendo una resistencia y capacidad de carga que le permita un desempeño igual o superior a los sistemas constructivos que actualmente se encuentran en aplicación. Además de ello, estos sistemas también imponen características físicas apropiadas en los materiales como son propiedades térmicas, antisísmicas, resistencia al fuego y una resistencia acústica aceptable. <br/><br/>	El trabajo de investigación realizado plantea el estudio de un sistema constructivo basado en paneles conformados por un alma de poliestireno expandido con una malla electrosoldada espacial, revestido externamente con hormigón, micro-hormigón o mortero proyectado en ambas caras. Actualmente este sistema constructivo se encuentra fuera de las normativas españolas, Instrucción de Hormigón Estructural EHE y la norma básica para la edificación NBE, ya que posee materiales no usados convencionalmente de manera estructural. <br/><br/>	Por tal motivo, la presente tesis pretende una investigación tanto del comportamiento mecánico del elemento, determinando sus propiedades físicas, mediante el uso de herramientas teóricas y experimentales, como de las técnicas de construcción que mejoren la capacidad estructural del sistema. Entre cuyos fundamentos se destacan el análisis del comportamiento como un sistema de tipo estructural, que cumpla con los requisitos necesarios para su aplicación a todo tipo de viviendas, incluso a viviendas de interés social, generando procesos y técnicas constructivas apropiadas para su mejor puesta en obra. <br/><br/>	Dentro de esta investigación se muestra una metodología para el cálculo estructural de este sistema constructivo basado como se menciona anteriormente en la Normativa Española vigente, si bien adaptado a las características específicas de estos elementos. Para corroborar dicha metodología, se realizaron una serie de campañas experimentales en elementos a diferente escala, igualmente se desarrolló una modelación de cálculo por medio del programa estructural SAP2000, ofreciendo resultados favorables en ambos casos.
Phase 1, Single‐ and Multiple‐Ascending‐Dose, Food‐Effect, and East Asian Subject Studies to Assess the Pharmacokinetics, Safety, and Tolerability of Bempedoic Acid, a Selective Inhibitor of Adenosine Triphosphate Citrate Lyase
Authors: Amore Benny M. , MacDougall Diane E. , Hanselman Jeffrey C. , Emery Maurice G. 
Published: July 2023

AbstractBempedoic acid is an adenosine triphosphate citrate lyase inhibitor that lowers low‐density lipoprotein cholesterol by inhibiting cholesterol synthesis and upregulating hepatic low‐density lipoprotein receptor expression. After oral dosing, bempedoic acid was readily absorbed, attaining maximum concentrations with a median time of 3.5 hours, and may be taken without regard to food. Steady‐state oral pharmacokinetics in healthy adults receiving bempedoic acid at the approved 180 mg/day dose were characterized by mean maximum concentration of 20.6 µg/mL, area under the concentration–time curve over 24 hours of 289 µg·h/mL, and elimination half‐life of 21.1 hours. Multiple‐dose pharmacokinetics were linear at bempedoic acid doses of 120–220 mg/day. Circulating concentrations of the active metabolite ESP15228 were 18.0% of bempedoic acid concentrations on average. Comparisons of bempedoic acid 180 mg/day pharmacokinetics after single and multiple dosing revealed no clinically meaningful differences between Japanese, Chinese, and Western subjects. Mean estimates of bempedoic acid elimination half‐life in Japanese (25.2 hours) and Chinese (20.0 hours) subjects were comparable to Western subjects (23.9 hours) following 14 days of once‐daily dosing. Bempedoic acid was generally safe and well tolerated up to a dose of 220 mg/day across the study populations described herein.
Reversible CO2 Fixation and Release by a Trinuclear Zn(II) Cryptate Complex and Operando Analysis of the Complex Structure
Authors: Murase Masakazu , Maegawa Yoshifumi , Ohashi Masataka , Goto Yasutomo , Sakamoto Naonari , Nonaka Takamasa , Uyama Takeshi , Arai Takeo 
Published: July 2023

AbstractMetal complexes inspired by carbonic anhydrase (CA), which is a metalloenzyme containing Zn(II), have been investigated as alternatives for CO2 fixation systems operating under ambient temperature and pressure conditions. In this study, we designed a trinuclear Zn(II) cryptate complex (Zn3L) and demonstrated rapid CO2 fixation with carbonation of CO2 using Zn3L. The CO2 fixation performance of Zn3L surpassed that of a standard CO2 absorbent, KOH(aq) solution, under conditions of the same solute concentration. In addition, the reaction achieved operation without support addition of base, which has been often required in systems of CA‐inspired complexes. Fixed CO2 was released by protonating polyazacryptate ligand (L) and breaking the complex structure, and deprotonation of L induced the reconstruction of Zn3L, allowing it to refix CO2. This reaction mechanism was proposed based on the analysis of operando extended X‐ray absorption fine structure spectroscopy. Zn3L also demonstrated the ability to capture dilute CO2 from air, and the volume of CO2 captured by Zn3L was approximately 2.6 times that captured by the KOH(aq) solution. Our Zn3L exhibited three valuable properties: rapid CO2 fixation without a base, reversibility, and ability to capture dilute CO2; thus Zn3L is a promising candidate as CO2 fixatives.
Zipper repair of 3 cm iatrogenic colonic perforation with dual‐channel endoscope and twin grasper‐assisted titanium clip
Authors: Yang Wei , Wen Wei , Ren Xiaoli , Zhai Qi , Li Shupei , Xuan Ji 
Published: July 2023

AbstractA 53‐year‐old man undergoing painless colonoscopy for long‐term diarrhea. After colonoscopy withdrawing to the sigmoid colon, a local perforation was found, about 3 cm in size, oval in shape. We used a two‐channel endoscope and grip to pull the edges of the intestinal wall on both sides of the perforation site to close together, and then repair the 3 cm oval perforation of the colon through multiple ordinary titanium clips. The patient had no obvious infection after surgery and recovered well after 1 month of follow‐up. Preliminary experience has shown that using multiple titanium clips under dual‐channel endoscope to zipper suture can effectively repair 3 cm iatrogenic colonic perforations.
Exploring the impact of clawback on pharmaceutical expenditure: A case study of public hospitals in Greece
Authors: Letsios Apostolos N. , Mavridoglou George , Ladopoulou Domniki , Tsourdini Despoina , Dedes Nikolaos , Polyzos Nikolaos M. 
Published: July 2023

AbstractSeveral European administrations have applied various mechanisms promoting cost containment to stabilise their budgets for pharmaceutical expenditure. Since 2016, Greece has adopted the clawback as a policy to contain the NHS hospitals' pharmaceutical expenditure, which increased significantly in the 2016–2020 period. The present study reviews the impact of this policy on the operation of NHS hospitals, the uninterrupted supply and rational use of their medicines, along with the sustainability of their finances. The trend of pharmaceutical expenditure for the period 2016–2020 is combined with further analysis of detailed drug consumption data of 15 sampled NHS hospitals. The data is classified by Anatomical Therapeutic Category (ATC) and the percentage of clawback distributed to each ATC and pharmaceutical company is calculated. It was found that a large proportion of the clawback is allocated to a few therapeutic categories (ATCs) and consequently, few pharmaceutical companies are particularly burdened. The increased burden on pharmaceutical companies, due to the continuous increase in the excessive pharmaceutical expenditure of the NHS hospitals and their limited budget, endangers the uninterrupted supply of medicines to hospitals and the viability of pharmaceutical companies. This issue was discussed in a scientific consensus group*, in which participants proposed ways to keep the level of pharmaceutical expenditure in line with patients' needs, the country's economic potential, and the sustainability of pharmaceutical companies.