bluuebunny/crossref_metadata_2025_split huggingface dataset:
Partner responses to low desire among couples coping with male hypoactive sexual desire disorder and associations with sexual well-being
Authors: Belu Charlene F , Corsini-Munt Serena , Dubé Justin P , Wang Grace A , Rosen Natalie O 
Published: June 2023

Abstract

Background
Hypoactive sexual desire disorder (HSDD) is characterized by persistently low desire and associated distress. Low desire is one of the most common sexual complaints among men and is associated with poor well-being. Interpersonal factors are key to understanding low desire, yet there are few dyadic studies of HSDD in men. Previous work on genito-pelvic pain and low desire in women has established that greater facilitative (eg, affectionate) partner responses are associated with greater sexual satisfaction and function and that more negative (eg, critical) or solicitous (eg, sympathetic, avoidant) partner responses are associated with lower sexual satisfaction and function. Examining how partner responses are associated with adjustment to HSDD may shed light on the interpersonal dynamics of this understudied sexual dysfunction.

Aim
In a cross-sectional study, we examined whether partner responses to low desire in men were associated with sexual desire, sexual satisfaction, and sexual distress for both members of the couple.

Methods
Men with HSDD and their partners (N  =  67 couples) completed measures of facilitative, negative, and avoidant partner responses to men’s low sexual desire—as perceived by the man with HSDD and self-reported by their partner—and sexual desire, sexual satisfaction, and sexual distress. Data were analyzed using multilevel modeling guided by the actor–partner interdependence model.

Outcomes
Outcomes included the partner-focused subscale of the Sexual Desire Inventory–2, Global Measure of Sexual Satisfaction, and Sexual Distress Scale–Revised.

Results
When men with HSDD perceived more facilitative partner responses to their low desire, they and their partners reported greater sexual satisfaction. When men with HSDD perceived and their partners self-reported more negative partner responses, they each reported lower sexual satisfaction. In addition, when men with HSDD perceived more avoidant partner responses, their partners reported greater sexual distress. Partner responses were not associated with sexual desire for either member of the couple.

Clinical Implications
Findings support the importance of the interpersonal context for HSDD in men and suggest potential future targets of treatment when working with affected couples.

Strengths and Limitations
This study is one of the only dyadic studies of HSDD in men, as assessed via clinical interview or self-report symptoms reviewed by the clinical team. Despite our best efforts to recruit this sample over 6 years, the small size limited power to detect all predicted effects.

Conclusion
More facilitative and fewer negative or avoidant partner responses to low desire are associated with greater sexual well-being in couples coping with HSDD.
Constraint propagation on GPU: A case study for the AllDifferent constraint
Authors: Tardivo Fabio , Dovier Agostino , Formisano Andrea , Michel Laurent , Pontelli Enrico 
Published: June 2023

Abstract
The AllDifferent constraint is a fundamental tool in Constraint Programming. It naturally arises in many problems, from puzzles to scheduling and routing applications. Such popularity has prompted an extensive literature on filtering and propagation for this constraint. This paper investigates the use of General Processing Units (GPUs) to accelerate filtering and propagation. In particular, the paper presents an efficient parallelization of the AllDifferent constraint on GPU, along with an analysis of different design and implementation choices and evaluation of the performance of the resulting system on several benchmarks.
How Fast is Your Detector? The Effect of Temporal Response on Image Quality
Authors: Mullarkey Tiarnan , Geever Matthew , Peters Jonathan J P , Griffiths Ian , Nellist Peter D , Jones Lewys 
Published: June 2023

Abstract
With increasing interest in high-speed imaging, there should be an increased interest in the response times of our scanning transmission electron microscope detectors. Previous works have highlighted and contrasted the performance of various detectors for quantitative compositional or structural studies, but here, we shift the focus to detector temporal response, and the effect this has on captured images. The rise and decay times of eight detectors' single-electron response are reported, as well as measurements of their flatness, roundness, smoothness, and ellipticity. We develop and apply a methodology for incorporating the temporal detector response into simulations, showing that a loss of resolution is apparent in both the images and their Fourier transforms. We conclude that the solid-state detector outperforms the photomultiplier tube–based detectors in all areas bar a slightly less elliptical central hole and is likely the best detector to use for the majority of applications. However, using the tools introduced here, we encourage users to effectively evaluate which detector is most suitable for their experimental needs.
The Effect of Body Armor on Pulmonary Function Using Plethysmography
Authors: Dunnick Dustin , Kins Keoni , Bhammar Dharini M , Schilling Brian K 
Published: June 2023

ABSTRACT
Military tactical athletes face the unique task of performing physically demanding occupational duties, often while wearing body armor. Forced vital capacity and forced expiratory volume measured using spirometry have been shown to decrease, while wearing plate-carrier style body armor, little is known about the comprehensive effects of wearing body armor on pulmonary function, including lung capacities. Further, the effects of loaded body armor vs. unloaded on pulmonary function are also unknown. Therefore, this study examined how loaded and unloaded body armor affects pulmonary function. Twelve college-aged males performed spirometry and plethysmography under three conditions (basic athletic attire [CNTL], unloaded plate carrier [UNL], and loaded plate carrier [LOAD]). Compared to CNTL, LOAD and UNL conditions significantly reduced functional residual capacity by 14% and 17%, respectively. Compared with CNTL, LOAD condition also showed a small but statistically significant lowered forced vital capacity (P = .02, d = 0.3), a 6% lower total lung capacity (P &lt; .01, d = 0.5), and lowered maximal voluntary ventilation (P = .04, d = 0.4). A loaded plate-carrier style body armor exerts a restrictive effect on total lung capacity, and both loaded and unloaded body armor affects functional residual capacity, which could impact breathing mechanics during exercise. Resulting endurance performance decreases may need to be factored based on the style and loading of body armor, especially for longer-duration operations.
Borrowing from the Past: Scarlattian Phrase Structure, Type 2 Sonatas, and Phrygian Tonality in Isaac Albéniz’s Works
Authors: Martín Entrialgo Alberto 
Published: June 2023

ABSTRACT
The importance of Domenico Scarlatti in nineteenth-century Spanish music has frequently been acknowledged. Likewise, comparisons between Isaac Albéniz’s and Scarlatti’s writing have been recurrent in Albéniz scholarship. Most of this literature, while referring to biographical circumstances, has mentioned their emulation of the guitar, their recourse to Spanish folklore, certain harmonic effects, and the use of the Phrygian mode and the so-called cadencia andaluza. However, phrase structural and formal procedures common to both composers have remained unnoticed, as, for instance, Albéniz’s use of the ‘type 2’ sonata as a way of emulating Scarlatti. The aim of this article is to offer some much-needed justification for such comparisons between Albéniz’s and Scarlatti’s music, devoting particular attention to Albéniz’s Iberia. The article also serves to put Albéniz at the centre of ongoing debates in the field of music theory, such as the application of ‘galant’ schemata to later music and in particular disputes about the interpretation of nineteenth-century sonata form from the perspective of eighteenth-century practice.
Radiative hydrodynamical simulations of super-Eddington accretion flow in tidal disruption event: the accretion flow and wind
Authors: Bu De-Fu , Qiao Erlin , Yang Xiao-Hong 
Published: June 2023

ABSTRACT
One key question in tidal disruption events theory is how much of the fallback debris can be accreted to the black hole. Based on radiative hydrodynamic simulations, we study this issue for efficiently ‘circularized’ debris accretion flow. We find that for a black hole disrupting a solar-type star, $15{{\, \rm per\, cent}}$ of the debris can be accreted for a 107 M⊙ black hole. While for a 106 M⊙ black hole, the value is $43{{\, \rm per\, cent}}$. We find that wind can be launched in the super-Eddington accretion phase regardless of the black hole mass. The maximum velocity of the wind can reach 0.7c (with c being the speed of light). The kinetic power of wind is well above 1044 erg s−1. The results can be used to study the interaction of wind and the circumnuclear medium around quiescent supermassive black holes.
Investigating the OH-H2 relation in diffuse Galactic clouds
Authors: Rawlins Katherine , Mookerjea Bhaswati 
Published: June 2023

Abstract
We investigate the correlation between OH and H2 column densities in diffuse Galactic clouds, in order to identify potential molecular tracers of interstellar H2. For this, we analyse near-UV spectra extracted from the ESO/VLT archives towards seventeen sightlines (five of them new) with known N(H2), along with nine sightlines with no H2 information. N(OH) shows only marginal correlation with N(H2) (1020 to 2 × 1021 cm−2), at the 95 per cent confidence level. We use orthogonal distance regression analysis to obtain N(OH) /N(H2) = (1.32±0.15) × 10−7, which is ∼ 33 per cent higher than the previous estimates based on near-UV data. We also obtain N(CH) /N(H2) = (3.83±0.23) × 10−8 and a significant correlation between N(OH) and N(CH), with N(OH) = (2.61±0.19) × N(CH), both of which are consistent with previous results. Comparison with predictions of numerical models indicate that OH absorption arises from diffuse gas (nH ∼ 50 cm−3) illuminated by radiation fields ∼ 0.5–5 G0, while CH is associated with higher density of 500 cm−3. We posit that the apparent dichotomy in the properties of the diffuse clouds giving rise to OH and CH absorption could be due to either (a) the presence of multiple spectroscopically unresolved clouds along the line-of-sight, or, (b) density gradients along the line-of-sight within a single cloud.
A Quantitative Theory for Genomic Offset Statistics
Authors: Gain Clément , Rhoné Bénédicte , Cubry Philippe , Salazar Israfel , Forbes Florence , Vigouroux Yves , Jay Flora , François Olivier 
Published: June 2023

Abstract
Genomic offset statistics predict the maladaptation of populations to rapid habitat alteration based on association of genotypes with environmental variation. Despite substantial evidence for empirical validity, genomic offset statistics have well-identified limitations, and lack a theory that would facilitate interpretations of predicted values. Here, we clarified the theoretical relationships between genomic offset statistics and unobserved fitness traits controlled by environmentally selected loci and proposed a geometric measure to predict fitness after rapid change in local environment. The predictions of our theory were verified in computer simulations and in empirical data on African pearl millet (Cenchrus americanus) obtained from a common garden experiment. Our results proposed a unified perspective on genomic offset statistics and provided a theoretical foundation necessary when considering their potential application in conservation management in the face of environmental change.
Dendritic cell vaccine trials in gliomas: Untangling the lines
Authors: Hotchkiss Kelly M , Batich Kristen A , Mohan Aditya , Rahman Rifaquat , Piantadosi Steven , Khasraw Mustafa 
Published: June 2023

Abstract
Glioblastoma is a deadly brain tumor without any significantly successful treatments to date. Tumor antigen-targeted immunotherapy platforms including peptide and dendritic cell (DC) vaccines, have extended survival in hematologic malignancies. The relatively “cold” tumor immune microenvironment and heterogenous nature of glioblastoma have proven to be major limitations to translational application and efficacy of DC vaccines. Furthermore, many DC vaccine trials in glioblastoma are difficult to interpret due to a lack of contemporaneous controls, absence of any control comparison, or inconsistent patient populations. Here we review glioblastoma immunobiology aspects that are relevant to DC vaccines, review the clinical experience with DC vaccines targeting glioblastoma, discuss challenges in clinical trial design, and summarize conclusions and directions for future research for the development of effective DC vaccines for patients.
Sialic acid metabolism orchestrates transcellular connectivity and signaling in glioblastoma
Authors: Kuliesiute Ugne , Joseph Kevin , Straehle Jakob , Madapusi Ravi Vidhya , Kueckelhaus Jan , Kada Benotmane Jasim , Zhang Junyi , Vlachos Andreas , Beck Juergen , Schnell Oliver , Neniskyte Urte , Heiland Dieter Henrik 
Published: June 2023

Abstract

Background
In glioblastoma (GBM), the effects of altered glycocalyx are largely unexplored. The terminal moiety of cell coating glycans, sialic acid, is of paramount importance for cell-cell contacts. However, sialic acid turnover in gliomas and its impact on tumor networks remain unknown.

Methods
We streamlined an experimental setup using organotypic human brain slice cultures as a framework for exploring brain glycobiology, including metabolic labeling of sialic acid moieties and quantification of glycocalyx changes. By live, 2-photon and high-resolution microscopy we have examined morphological and functional effects of altered sialic acid metabolism in GBM. By calcium imaging we investigated the effects of the altered glycocalyx on a functional level of GBM networks.

Results
The visualization and quantitative analysis of newly synthesized sialic acids revealed a high rate of de novo sialylation in GBM cells. Sialyltrasferases and sialidases were highly expressed in GBM, indicating that significant turnover of sialic acids is involved in GBM pathology. Inhibition of either sialic acid biosynthesis or desialylation affected the pattern of tumor growth and lead to the alterations in the connectivity of glioblastoma cells network.

Conclusions
Our results indicate that sialic acid is essential for the establishment of GBM tumor and its cellular network. They highlight the importance of sialic acid for glioblastoma pathology and suggest that dynamics of sialylation have the potential to be targeted therapeutically.
The effects of carbohydrate-restricted diet on psychological outcomes: a systematic review of randomized controlled trials
Authors: Sindler Dominik , Kastovska Barbora , Dostal Tomas , Cipryan Lukas , Elavsky Steriani 
Published: June 2023

Abstract

Context
Carbohydrate-restricted diets are widely used as an effective treatment tool for many chronic diseases. The impact of these diets on physical health is well known, but their impact on psychological health is less well described in the scientific literature. This is an important aspect to focus on, especially if the diets are to be sustainable in the long term.

Objective
The objective of this study was to systematically review the scientific literature describing the effect of carbohydrate-restricted diets and ketogenic diets on psychological outcomes, as observed in randomized controlled trials. Additionally, the potential synergistic effect of carbohydrate-restricted diets and exercise or social factors on these outcomes was researched.

Data Sources
Five databases (Web of Science, PubMed, Scopus, ScienceDirect, and MEDLINE Complete) were searched without restriction of publication date.

Data Extraction
The first data extraction was made in October 2020 and the second in May 2022. Abstract screening was performed by 3 independent reviewers. The quality of studies was assessed using the Jadad scale.

Data Analysis
Sixteen randomized controlled studies were included in the analysis. Five studies focused on clinical populations, 9 on obese/overweight populations, and 2 on healthy populations; all studies examined adult people. Four psychological outcomes were identified (quality of life, mental health, mood, and fatigue), and they were examined in connection with a very low-carbohydrate or ketogenic diet.

Conclusion
Daily low-carbohydrate intake may not negatively affect psychological well-being, and low-carbohydrate diets and ketogenic diets are no worse than other diets in this respect. An intervention of 12 weeks or longer can bring benefits in psychological well-being. The synergistic effect of diet and exercise or social factors was not reviewed due to lack of evidence.
Olanzapine With or Without Fosaprepitant for Preventing Chemotherapy Induced Nausea and Vomiting in Patients Receiving Highly Emetogenic Chemotherapy: A Phase III Randomized, Double-Blind, Placebo-Controlled Trial (ALLIANCE A221602)
Authors: Navari Rudolph M , Le-Rademacher Jennifer , Smieliauskas Fabrice , Ruddy Kathryn J , James Saphner Thomas , Liu Heshan , Harlos Elizabeth , Onitilo Adedayo A , Giridhar Karthik , Paul Singh Preet , Reddy Pavan S , Chow Selina , Kruter Flavio , Raptis George , Loprinzi Charles L 
Published: June 2023

Abstract

Purpose
A protocol was developed to evaluate the value of an NK-1 receptor antagonist for preventing nausea and vomiting resulting from highly emetogenic chemotherapy when an olanzapine-based antiemetogenic regimen was used.

Materials and Methods
A221602, a prospective double-blind, placebo-controlled clinical trial, was developed to compare 2 ­olanzapine-containing antiemetic regimens, one with an NK-1 receptor antagonist (aprepitant or fosaprepitant) and one without. Trial patients had a malignant disease for which they received intravenous highly emetogenic chemotherapy (single day cisplatin ≥ 70 mg/m2 or doxorubicin plus cyclophosphamide on 1 day). Patients on both arms received commonly administered doses of a 5-HT3 receptor antagonist, dexamethasone, and olanzapine. Additionally, patients were randomized to receive an NK-1 receptor antagonist (fosaprepitant 150 mg IV or aprepitant 130 mg IV) or a corresponding placebo. The primary objective was to compare the proportion of patients with no nausea for 5 days following chemotherapy between the 2 study arms. This trial was designed to test for the noninferiority of deleting the NK-1 receptor antagonist, with noninferiority defined as a decrease in freedom from nausea by less than 10%.

Results
A total of 690 patients were entered on this trial, 50% on each arm. The proportion of patients without nausea for the complete 5-day study period was 7.4% lower (upper limit of the one-sided 95% confidence interval was 13.5%) in the arm without an NK-1 receptor antagonist compared with the arm with an NK-1 receptor antagonist.

Conclusion
This trial did not provide sufficient evidence to support that deletion of the NK-1 receptor antagonist was as good as keeping it, as a part of a 4-drug antiemetic regimen for highly emetogenic chemotherapy (ClinicalTrials.gov Identifier: NCT03578081).
Pre-Diagnosis Pain in Patients With Pancreatic Cancer Signals the Need for Aggressive Symptom Management
Authors: McNearney Terry A , Digbeu Biai Dominique Elmir , Baillargeon Jacques G , Ladnier Dennis , Rahib Lola , Matrisian Lynn M 
Published: June 2023

Abstract

Objective
This study assessed the impact of pancreatic cancer (PC) pain on associated symptoms, activities, and resource utilization from 2016 to 2020 in an online patient registry.

Patients and Methods
Responses from PC patient volunteers (N = 1978) were analyzed from online surveys in a cross-sectional study. Comparisons were performed between PC patient groups reporting, (1) the presence vs. absence of pre-diagnosis PC pain, (2) high (4-8) vs. low (0-3) pain intensity scores on an 11-point numerical rating scale (NRS), and (3) year of PC diagnosis (2010-2020). Descriptive statistics and all bivariate analyses were performed using Chi-square or Fisher’s Exact tests.

Results
PC pain was the most frequently reported pre-diagnosis symptom (62%). Pre-diagnostic PC pain was reported more frequently by women, those with a younger age at diagnosis, and those with PC that spread to the liver and peritoneum. Those with pre-diagnostic PC pain vs. those without reported higher pain intensities (2.64 ± 2.54 vs.1.56 ± 2.01 NRS mean ± SD, respectively, P = .0039); increased frequencies of post-diagnosis symptoms of cramping after meals, feelings of indigestion, and weight loss (P = .02-.0001); and increased resource utilization in PC pain management: (ER visits N = 86 vs. N = 6, P = .018 and analgesic prescriptions, P &lt; .03). The frequency of high pain intensity scores was not decreased over a recent 11-year span.

Conclusions
PC pain continues to be a prominent PC symptom. Patients reporting pre-diagnosis PC pain experience increased GI metastasis, symptoms burden, and are often undertreated. Its mitigation may require novel treatments, more resources dedicated to ongoing pain management and surveillance to improve outcomes.
Immune-Related Adverse Events and Clinical Outcomes in Advanced Urothelial Cancer Patients Treated With Immune Checkpoint Inhibitors
Authors: Sanda Gregory E , Shabto Julie M , Goyal Subir , Liu Yuan , Martini Dylan J , Nazha Bassel , Brown Jacqueline T , Yantorni Lauren B , Anne Russler Greta , Caulfield Sarah , Joshi Shreyas S , Narayan Vikram M , Kissick Haydn , Ogan Kenneth , Master Viraj A , Carthon Bradley C , Kucuk Omer , Bilen Mehmet Asim 
Published: June 2023

Abstract

Background
In advanced urothelial cancers (UC), immune checkpoint inhibitors (ICI) show promise as a durable therapy. Immune-related adverse events (irAEs), a side effect of ICIs, may serve as an indicator of beneficial response. We investigated the relationship between irAEs and clinical outcomes in patients with advanced UC who received ICI.

Materials and Methods
In this retrospective study, we investigated 70 patients with advanced UC treated with ICIs at Winship Cancer Institute from 2015 to 2020. Data on patients were collected through chart review. Cox’s proportional hazard model and logistic regression were applied to estimate the association with overall survival (OS), progression-free survival (PFS), and clinical benefit (CB). The possible lead-time bias was handled in extended Cox regression models.

Results
The median age of the cohort was 68. Over one-third (35%) of patients experienced an irAE, with skin being the most frequent organ involved (12.9%). Patients that experienced at least one irAE had significantly enhanced OS (HR: 0.38, 95% CI, 0.18-0.79, P = .009), PFS (HR: 0.27, 95% CI, 0.14-0.53, P &lt; .001), and CB (OR: 4.20, 95% CI, 1.35-13.06, P = .013). Patients who experienced dermatologic irAEs also had significantly greater OS, PFS, and CB.

Conclusion
Of patients with advanced UC that had undergone ICI therapy, those who had irAEs, especially dermatologic irAEs, had significantly greater OS, PFS, and CB. These results may suggest that irAE’s may serve as an important marker of durable response to ICI therapy in urothelial cancer. The findings of this study need to be validated with larger cohort studies in the future.