bluuebunny/crossref_metadata_2025_split huggingface dataset:
Shared rules between planetary orbits existing in multi-planet systems and their functions
Authors: Ma Yong , Wen Xiumei 
Published: January 2023

Abstract
Nearly 300 systems containing three or more confirmed planets have been discovered, which have the potential to reflect more orbital features in addition to mean motion resonances (MMRs) since they are all controlled by the same central gravitation. By using the method of orbital ratio parameter analysis, we calculated the observation data of the planetary orbits of these systems. The calculations show the orbital relationships between all planets of each system in a clearer quantification way, including the planets of MMRs. By comparisons and statistics, we found some features shared by different systems. We summarized these features into the shared rules between planetary orbits, from which we derived related equations, principles and traits. We will offer explanations. The shared rules, more likely appearing along with system formation, can help learn about the true planetary configuration of a system and its change. Because of varying factors, many systems show large deviation rates, which affect the clear display of the shared rules. Even so, the calculation with corresponding equations and judgment according to corresponding principles still reflect that the shared rules exist in 88 of the 101 extrasolar systems containing four or more planets. We further analyzed these systems, provided the suggestions of migratory and absent exoplanets, and calculated related orbits. Meanwhile, we summarized five main reasons for large deviation rates, which can objectively explain why some systems do not clearly show the shared rules. The shared rules provide a new approach for studying the changes in planetary configurations, the completeness of multi-planet systems, and their evolution.
Biological invasions as burdens to primary economic sectors.
Authors: Turbelin Anna J. , Hudgins Emma J. , Catford Jane A. , Cuthbert Ross N. , Diagne Christophe , Kourantidou Melina , Roiz David , Courchamp Franck 
Published: January 2023

Abstract

Many human-introduced alien species economically impact essential industries worldwide. Management prioritization and coordination efforts towards biological invasions are hampered by a lack of comprehensive quantification of costs to key economic activity sectors. Here, we quantify and predict global invasion costs to seven major sectors and unravel the introduction pathways of species causing these costs — focusing mainly on resource-based agriculture, fishery and forestry industries. From 1970 to 2020, costs reported in the InvaCost database as pertaining to Agriculture, Fisheries, and Forestry totaled $509 bn, $1.3 bn, and $134 bn, respectively (in 2017 United States dollars). Pathways of costly species were diverse, arising predominantly from cultural and agricultural activities, through unintentional contaminants with trade, and often impacted different sectors than those for which species were initially introduced. Costs to Agriculture were pervasive and greatest in at least 37% (n = 46/123) of the countries assessed, with the United States accumulating the greatest costs for resource-based industries ($365 bn), followed by China ($101 bn), and Australia ($36 bn). We further identified 19 countries highly economically reliant on Agriculture, Fisheries, and Forestry that are experiencing massive economic impacts from biological invasions, especially in the Global South. Based on an extrapolation to fill cost data gaps, we estimated total global costs ranging at least from $517 − 1,400 bn for Agriculture, $5.7–6.5 bn for Fisheries, and $142–768 bn for Forestry, evidencing substantial underreporting in the Forestry sector in particular. Burgeoning global invasion costs challenge sustainable development and urge for improved management action to reduce future impacts on industry.
CURRICULARIZAÇÃO DA EXTENSÃO UNIVERSITÁRIA FRENTE AOS MARCOS LEGAIS
Authors: FERREIRA FERNANDA EMANUELA , Aguena Rafael , Perdoná Gabriela , Scheffer Daniel , Soares Thiago , Andrade de Lima Mauricio Andrade de Lima 
Published: January 2023

A publicação do Plano Nacional de Educação (2014-2024), à luz da Lei nº 13.0005/2014 trouxe o desafio importante às instituições de ensino superior diante da necessidade de revisão dos currículos dos cursos superiores para atendimento à Meta 12, Estratégia 12.7. Este estudo propõe a análise do cenário da curricularização da extensão no Instituto Federal de Educação, Ciência e Tecnologia de Santa Catarina, considerando os marcos legais vigentes que orientam a gestão da extensão universitária. O delineamento metodológico traz um estudo de caso, de abordagem qualitativa, de natureza aplicada e objetivos descritivos. Para obtenção de resultados foram utilizados dados primários por meio de entrevistas semiestruturadas e dados secundários por meio de análise documental e bibliografia pertinente ao tema. Os resultados da pesquisa indicam que o IFSC apresenta suas normativas institucionais alinhadas aos marcos legais federais ao que tange a curricularização, porém indicam que há necessidade de reconhecimento do IFSC pela sociedade por meio da extensão. A adequação aos processos que dão suporte à curricularização da extensão é necessário para que o IFSC possa atender aos marcos legais federais vigentes até 2024, prazo do Plano Nacional de Educação.
Duchenne Muscular Dystrophy Management and Treatment Access Challenges:
Case Report
Authors: El-Azzabi Tarek I. 
Published: January 2023

Introduction:
Duchenne muscular dystrophy (DMD) is a rare neuromuscular disease that causes muscle weakness with respiratory and cardiac complications. International DMD standard of care guidelines exist, but their implementation and DMD treatment access in the Middle East have historically been challenging. This report highlights sub-optimal management of DMD in the Middle East together with recommendations for best practices, and the first reported use of ataluren, a mutation-specific treatment for nonsense mutation DMD (nmDMD), in this region.

Case Presentation:
The management of two patients in the United Arab Emirates diagnosed with nonsense mutation DMD is described. Under multidisciplinary care, both patients were treated with corticosteroids as per international DMD standard of care guidelines. Although both patients presented with typical DMD signs/symptoms, one received a genetic diagnosis and treatment relatively late owing to low awareness of the early signs and symptoms of DMD among physicians in the region; delayed genetic diagnosis of DMD hinders early initiation of mutation-specific treatments such as ataluren. Moreover, this patient demonstrated low adherence to the treatment plan, potentially resulting from low DMD awareness and poor understanding of the-risk-benefit of corticosteroids in the patient’s family. In contrast, the other patient was genetically diagnosed early at 25 months, was administered ataluren whilst ambulatory, and demonstrated high adherence to the management plan. Limited expertise in performing motor function assessments and complications with medical insurance for ataluren in the region created additional obstacles in the management of both patients.

Conclusions:
The contrasting experiences of these patients highlight the high variability of diagnosis and management of DMD in the Middle East. There is a need in the region to boost disease education for both public and professional communities, establish local DMD networks and guidelines, and improve access to treatments to improve the quality of care that patients with DMD receive.
Circ_0002762 Regulates Oncoprotein YBX1 in Cervical Cancer via
mir-375 to Regulate the Malignancy of Cancer Cells
Authors: Wang Chunjie , Hou Li , Zheng Wei , Mu Haixia , Chen Jing 
Published: January 2023

Background:
Cervical carcinoma (CC) is the third most common cancer among females and the fourth leading cause of cancer-related death, which poses a serious threat to women's health. This study investigated the biological function and mechanism of circRNA circ_0002762 in the malignant progression of CC.

Methods:
Quantitative real-time polymerase chain reaction (qRT-PCR) was used to quantify circ_0002762, microRNA-375 (miR-375) and Y-box binding protein 1 (YBX1) mRNA expressions in CC tissues and cell lines. After circ_0002762 was overexpressed in CC cell lines, cell counting kit-8 (CCK-8), 5-Ethynyl-2'-deoxyuridine (EdU) and wound healing assays were executed to probe cell growth and migration. Additionally, the targeting relationships between miR-375 and circ_0002762 or YBX1 3’-UTR were confirmed by dual-luciferase reporter assay and RNA immunoprecipitation assay. Western blot was adopted to examine YBX1 protein levels in CC cells.

Results:
Circ_0002762 expression was raised in CC tissues and cell lines, and highly expressed circ_0002762 was associated with larger tumor size and lymph node metastasis of CC patients. Circ_0007262 overexpression markedly accelerated the proliferation and migration of CC cells. Besides, miR-375 was revealed to be a downstream target of circ_0002762, and miR-375 overexpression counteracted the promoting effects of circ_0002762 overexpression on CC cell viability and migration. YBX1 was identified as a target of miR-375, and circ_0002762 positively modulated YBX1 expressions through adsorbing miR-375.

Conclusion:
Circ_0002762 promotes the progression of CC via sponging miR-375 and up-regulating YXB1 expression.
Adhesion Molecules as Prognostic Biomarkers in Coronary Artery Disease
Authors: Sagris Marios , Theofilis Panagiotis , Antonopoulos Alexios S. , Oikonomou Evangelos , Simantiris Spiros , Papaioannou Spyridon , Tsioufis Constantinos , Tousoulis Dimitris 
Published: January 2023

Abstract:
Atherosclerosis is a progressive disease, culminating in the production of atherosclerotic plaques in arteries through intricate pathophysiological processes. The progression of this disorder is based on the effect of triggering factors -mainly hyperlipidemia, diabetes mellitus, arterial hyper-tension, and smoking- on the endothelium. Coronary artery disease (CAD) is an atherosclerotic dis-ease with a higher prevalence among individuals. Pro- and anti-inflammatory cytokines are the main contributors to atherosclerotic plaque formation. CAD and its manifestations multifactorial af-fect patients’ quality of life, burdening the global healthcare system. Recently, the role of adhesion molecules in CAD progression has been recognized. Physicians delve into the pathophysiologic ba-sis of CAD progression, focusing on the effect of adhesion molecules. They are proteins that medi-ate cell-cell and cell-extracellular matrix interaction and adhesion, driving the formation of athero-sclerotic plaques. Several studies have assessed their role in atherosclerotic disease in small cohorts and in experimental animal models as well. Furthermore, several agents, such as nanoparticles, have been introduced modifying the main atherosclerotic risk factors as well as targeting the endothelial inflammatory response and atherosclerotic plaque stabilization. In this review, we discuss the role of adhesion molecules in atherosclerosis and CAD progression, as well as the potential to be used as targeting moieties for individualized treatment.
The Role of Total White Blood Cell Count in Antipsychotic Treatment for
Patients with Schizophrenia
Authors: Zhang Yamin , Tao Shiwan , Coid Jeremy , Wei Wei , Wang Qiang , Yue Weihua , Yan Hao , Tan Liwen , Chen Qi , Yang Guigang , Lu Tianlan , Wang Lifang , Zhang Fuquan , Yang Jianli , Li Keqing , Lv Luxian , Tan Qingrong , Zhang Hongyan , Ma Xin , Yang Fude , Li Lingjiang , Wang Chuanyue , Zhao Liansheng , Deng Wei , Guo Wanjun , Ma Xiaohong , Zhang Dai , Li Tao 
Published: January 2023

Background:
Total white blood cell count (TWBCc), an index of chronic and low-grade
inflammation, is associated with clinical symptoms and metabolic alterations in patients with schizophrenia.
The effect of antipsychotics on TWBCc, predictive values of TWBCc for drug response, and
role of metabolic alterations require further study.

Methods:
Patients with schizophrenia were randomized to monotherapy with risperidone, olanzapine,
quetiapine, aripiprazole, ziprasidone, perphenazine or haloperidol in a 6-week pharmacological trial.
We repeatedly measured clinical symptoms, TWBCc, and metabolic measures (body mass index,
blood pressure, waist circumference, fasting blood lipids and glucose). We used mixed-effect linear
regression models to test whether TWBCc can predict drug response. Mediation analysis to investigate
metabolic alteration effects on drug response.

Results:
At baseline, TWBCc was higher among patients previously medicated. After treatment with
risperidone, olanzapine, quetiapine, perphenazine, and haloperidol, TWBCc decreased significantly (p
< 0.05). Lower baseline TWBCc predicted greater reductions in Positive and Negative Syndrome
Scale (PANSS) total and negative scores over time (p < 0.05). We found significant mediation of
TWBCc for effects of waist circumference, fasting low-density lipoprotein cholesterol, and glucose on
reductions in PANSS total scores and PANSS negative subscale scores (p < 0.05).

Conclusion:
TWBCc is affected by certain antipsychotics among patients with schizophrenia, with
decreases observed following short-term, but increases following long-term treatment. TWBCc is predictive
of drug response, with lower TWBCc predicting better responses to antipsychotics. It also mediates
the effects of certain metabolic measures on improvement of negative symptoms. This indicates
that the metabolic state may affect clinical manifestations through inflammation.
Reducing Hepatotoxicity Mechanism of Radix Wikstroemia Indica by
Processing with “Sweat Soaking Method” Using UPLC-MS/MS and a
Cocktail Probe Substrate
Authors: Su Hongmei , Feng Guo , Xu Qin , Li Wei , Liu Wen , Wu Zengguang , Li Lailai , Wang Wenjing , Zhu Guanglin , Ren Chenchen , Song Xueli , Zhang Ju , He Zhengyan 
Published: January 2023

Background:
Radix Wikstroemia indica is a traditional Chinese medicine (TCM) used as anti-inflammatory and anti-tumor drug. However, it has serious hepatotoxicity, "Sweat soaking method" processed could effectively decrease its hepatotoxicity.

Objective:
The objective of this study is to study the effects of Radix Wikstroemia indica on six kinds of cytochrome P450(CYP450) isozymes of rat liver microsomes before and after processing, and to study the mechanism of Radix Wikstroemia indica processed by the "Sweat soaking method" to reduce liver toxicity in rats.

Methods:
In this study, the effects of Radix Wikstroemia indica and processed Radix Wikstroemia indica on the six main CYP450 isoforms (2E1, 1A2, 2C6, 2D1, 2C11, and 3A1) were investigated in vitro. Using a cocktail probe of CYP450 isoform-specific substrates and their metabolites, we carried out in vitro enzymatic studies in liver microsomal incubation systems via UPLC-MS/MS.

Results:
The results showed that the established UPLC-MS/MS method was precise and reliable. Compared with the blank group, the activities of six enzymes in the RWI and PRWI groups were higher than those in the blank group. At the same dose, the enzyme activities of CYP2E1, CYP1A2, CYP2C6, CYP2C11, and CYP3A1 increased with the increase in dose, and the enzyme activities of the RWI group were higher than those of the PRWI group. The enzyme activities of CYP2E1 and CYP1A2 in the Radix Wikstroemia indica group were significantly increased compared with the blank group, CYP3A1 in the RWI high-dose group was higher than that in the blank group and PRWI group with statistical differences (p<0.05 or p<0.01).

Conclusion:
The processed Radix Wikstroemia indica could reduce liver injury, and its detoxication mechanism might be related to the decrease in enzyme activity of CYP1A2, CYP2E1 and CYP3A1.
The Composite Quality Score (CQS) as an Appraisal Tool for Prospective,
Controlled Clinical Therapy Trials: Rationale and Current Evidence
Authors: Mickenautsch Steffen , Rupf Stefan , Miletić Ivana , Yengopal Veerasamy 
Published: January 2023

Background:
Current evidence appraisal concepts, such as the Assessment,
Development and Evaluation (GRADE) approach and Cochrane’s Risk of Bias (RoB) tool, rely on
assumptions related to the classic problem of inductive reasoning and may suffer from insufficient
inter-rater reliability.

Discussion:
The Composite Quality Score (CQS) has emerged as a possible trial appraisal tool
that does not rely on inductive assumptions and has been shown to be of potentially very high
inter-rater reliability.

Conclusion:
Although the current CQS concept is still under development, its current evidence is
encouraging and justifies further study. This article presents the rationale and currently available
research concerning the CQS and shows where further research is required.
Recent Advances in Direct Pyridine C-H Activation Strategies
Authors: Roy Sushmita 
Published: January 2023

Background:Pyridine is one of the most ubiquitous hetero-aromatic moieties in pharmaceutical chemistry and it has enormous importance in a plethora of fields. From a synthetic chemistry standpoint, pyridine moiety has been used as a directing group in C-H activation strategies to functionalize various rings. However, this unique feature to participate as a directing group hinders developing methodologies to carry out C-H activation on the pyridine ring itself. One of the simplest solutions is to block the activity of ring nitrogen at the cost of two extra steps. Here, in this review, along with the blocking, we will briefly mention some interesting ways to get around this problem and the remaining challenges ahead.Objective:The coordinating ability of pyridine N poses a big challenge toward C-H functionalization on the pyridine ring. This review summarizes some of the recent methods towards this challenge.Method:Some key ideas towards that goal have been described. Here, the C-H activation strategies are categorised as follows: (1) Pyridine N-oxide mediated C-H activation, (2) Dimerization of C-H activation of pyridine, (3) Direct Pyridine C2-H activation, (4) Direct Pyridine C3-H activation and (5) Direct Pyridine C4-H activation.Results:Several methods have been highlighted that can be utilised to prepare C-H functionalized products with regiospecificity that subsequently may be manipulated into interesting products which are difficult to attain easily.Conclusion:This review explores various new direct C-H activation methods on pyridine which attempts to fill the void of traditional synthetic protocols in regard to regioselective pyridine functionalization. This review also explores the limitations of current methodologies which must be wiped off to attain a mature state in need of the pharmaceutical industry.
Parasites as Metal Corrosion Inhibitors, New Achievements
Authors: Rassouli Maryam , Azadi Mahboobeh 
Published: January 2023

Abstract:
Green inhibitors for metal corrosion were mostly known as plant extracts but in the series of
studies, parasites had some active biomaterials that inhibited metal corrosion. The extracts of different
parasites, tick (Hyalomma), fly larva (Oestrus), and leech (Hirudo) were used in acidic media for metal
corrosion inhibition. Total proteins of Hyalomma and Hirudo were also extracted and used for the investigation
of protein role in metal corrosion inhibition. In extract examinations, parasites can be candidates
for green inhibition of metal corrosion. During the experiment processes, the collagen of Hirudo was
dissolved and the chitin of arthropods was also dissolved to chitosan and coated the metal surfaces. In the
extracted proteins examinations, the corrosion inhibition of Hirudo was much better than Hyalomma.
According to different research, arthropods (as chitin-rich) and leech (as collagen-rich) parasites could
inhibit metal corrosion in acidic media, suggesting a bridge between parasitology and engineering.
Rancang Bangun Sistem Informasi Lokasi Meja Pada Food Court Menggunakan RFID (Radio Frequency Identification) Berbasis Aplikasi Android
Authors: Hastuti Sri , Hastuti Sri 
Published: January 2023

Abstrack- Food court locations are placed in current visited places and usually many customer tables that are widely scattered there. It can be too slowly and inefficient ordering, both in terms of time and the process of delivering order because of difficulty of finding a customer table. Based on the explanation above, the authors make a design and build a table location information system in the food court using RFID based android applications. This system allows customers to inform the location of the table to food vendors using RFID. In designing hardware devices, a NodeMCU ESP8266 microcontroller is needed and for designing android software applications using APP Inventor. Google Firebase's realtime database platform was chosen to connect hardware and software devices. The measurement results from the design of this system show that the system is capable of producing precise RFID reading output with an accuracy level of 100% according to the location of the buyer's table. Meanwhile, the average delay obtained from this system is 0.81 seconds. This tool can read the RFID card without a barrier as far as 4.1 cm and cannot read the card if blocked by a metal material.Â Keywords: Food Court, RFID, NodeMCU ESP8266, App Invetor2, FirebaseÂ
Editorial policy of Kedaulatan Rakyat, Tribun Jogja, and Harian Jogja in reporting regional management by Kasultanan Ngayogyakarta Hadiningrat
Authors: Adikara Gilang Jiwana 
Published: January 2023

The Province of the Special Region of Yogyakarta is an anomaly in a democratic country. The position of regional head in this province is held by the Ngayogyakarta Hadiningrat Sultanate which adheres to a monarchical system so that regional management experiences various obstacles, such as internal palace conflicts or allegations of maladministration. As mass media whose freedom is regulated by law, the three mass media in DIY also have to deal with a unique local government system. This study discusses the editorial policies of three local media in Yogyakarta: Kedaulatan Rakyat, Tribun Jogja, and Harian Jogja regarding the DIY government under the Ngayogyakarta Hadiningrat Sultanate and maps out the factors that influence the editorial policy. Indepth interview were conducted to each of the media representatives to obtain data that then analyzed. This study concludes that each media is more careful in criticizing and controlling the government. Various factors also influence this policy, both at the individual level, media routines, organizations, social institutions, and social systemsThis research concludes that the editorial policy is more careful in the function of control and criticism as well as the existence of various factors both at the individual level, media routines, organizations, social institutions, and social systems that underlie these decisions.