bluuebunny/crossref_metadata_2025_split huggingface dataset:
Validation of Chronocancer camilosantanai† Santana, Tavares, Martins, Melo & Pinheiro (Crustacea, Decapoda, Brachyura) from the Romualdo Formation, Araripe Sedimentary Basin, Brazil
Authors: Santana William Ricardo Amâncio , Tavares Marcos Domingos Siqueira , Martins Carlos Antônio Muniz , Melo José Patrício Pereira , Pinheiro Allysson Pontes 
Published: May 2023

Santana et al. (2022) described a new genus and species of fossil crab, Chronocancer camilosantanai, from carbonate concretions of the Romualdo Formation of the Araripe Sedimentary Basin. The journal in which the description appeared was published online only and the new name did not include a ZooBank registration number (LSID), as required for validation of new names in electronic-only publications. The present note serves to validate the name Chronocancer camilosantanai by fulfilling the ICZN conditions for nomenclatural availability. The date and authorship of the specific name, accordingly, are those of this note, not Santana et al. (2022).
Destombamento através do tempo: as (des)construções das políticas de preservação do patrimônio cultural brasileiro
Authors: Soares Carolina Pedro 
Published: May 2023

Com o objetivo de fazer aproximações entre os casos de destombamento ocorridos na década de 1940, durante o Regime Varguista, e os três casos atuais, dos anos 2021 e 2022, o artigo propõe uma breve reflexão sobre o estabelecimento do decreto-lei nº 3866/1941, quando se constituiu legalmente o cancelamento do tombamento. A reflexão permite iluminar alguns casos anteriores, conectando suas semelhanças e divergências com aqueles ocorridos no século XXI. Coloca-se em perspectiva a utilização do dispositivo jurídico, enfatizando as diferenças dos processos históricos que os balizaram, na perda da memória relacionada à perda da materialidade e a preservação de ruínas.
Heterogeneity in Cardiovascular Disease Risk Factors Among Latino Immigrant Subgroups: Evidence From the 2010 to 2018 National Health Interview Survey
Authors: Elias Sabrina , Turkson‐Ocran Ruth‐Alma , Koirala Binu , Byiringiro Samuel , Baptiste Diana , Himmelfarb Cheryl R. , Commodore‐Mensah Yvonne 
Published: May 2023

Background
The Latino population is a growing and diverse share of the US population. Previous studies have examined Latino immigrants as a homogenous group. The authors hypothesized that there would be heterogeneity in cardiovascular disease risk factors among Latino immigrant subgroups (from Mexico, Puerto Rico, Cuba, Dominican Republic, Central America, or South America) compared with non‐Latino White adults.

Methods and Results
A cross‐sectional analysis of the 2010 to 2018 National Health Interview Survey (NHIS) among 548 739 individuals was performed. Generalized linear models with Poisson distribution were fitted to compare the prevalence of self‐reported hypertension, overweight/obesity, diabetes, high cholesterol, physical inactivity, and current smoking, adjusting for known confounders. The authors included 474 968 non‐Latino White adults and 73 771 Latino immigrants from Mexico (59%), Puerto Rico (7%), Cuba (6%), Dominican Republic (5%), Central America (15%), and South America (9%). Compared with White adults, Mexican immigrants had the highest prevalence of overweight/obesity (prevalence ratio [PR], 1.17 [95% CI, 1.15–1.19]); Puerto Rican individuals had the highest prevalence of diabetes (PR, 1.63 [95% CI, 1.45–1.83]); individuals from Central America had the highest prevalence of high cholesterol (PR, 1.16 [95% CI, 1.04–1.28]); and individuals from the Dominican Republic had the highest prevalence of physical inactivity (PR, 1.25 [95% CI, 1.18–1.32]). All Latino immigrant subgroups were less likely to be smokers than White adults.

Conclusions
The authors observed advantages and disparities in cardiovascular disease risk factors among Latino immigrants. Aggregating data on Latino individuals may mask differences in cardiovascular disease risk and hinder efforts to reduce health disparities in this population. Study findings provide Latino group–specific actionable information and targets for improving cardiovascular health.
Treatment With Small Molecule Inhibitors of Advanced Glycation End‐Products Formation and Advanced Glycation End‐Products‐Mediated Collagen Cross‐Linking Promotes Experimental Aortic Aneurysm Progression in Diabetic Mice
Authors: Li Yankui , Zheng Xiaoya , Guo Jia , Samura Makoto , Ge Yingbin , Zhao Sihai , Li Gang , Chen Xiaofeng , Shoji Takahiro , Ikezoe Toru , Miyata Masaaki , Xu Baohui , Dalman Ronald L. 
Published: May 2023

Background
Although diabetes attenuates abdominal aortic aneurysms (AAAs), the mechanisms by which diabetes suppresses AAAs remain incompletely understood. Accumulation of advanced glycation end‐ (AGEs) reduces extracellular matrix (ECM) degradation in diabetes. Because ECM degradation is critical for AAA pathogenesis, we investigated whether AGEs mediate experimental AAA suppression in diabetes by blocking AGE formation or disrupting AGE‐ECM cross‐linking using small molecule inhibitors.

Methods and Results
Male C57BL/6J mice were treated with streptozotocin and intra‐aortic elastase infusion to induce diabetes and experimental AAAs, respectively. Aminoguanidine (AGE formation inhibitor, 200 mg/kg), alagebrium (AGE‐ECM cross‐linking disrupter, 20 mg/kg), or vehicle was administered daily to mice from the last day following streptozotocin injection. AAAs were assessed via serial aortic diameter measurements, histopathology, and in vitro medial elastolysis assays. Treatment with aminoguanidine, not alagebrium, diminished AGEs in diabetic AAAs. Treatment with both inhibitors enhanced aortic enlargement in diabetic mice as compared with vehicle treatment. Neither enhanced AAA enlargement in nondiabetic mice. AAA enhancement in diabetic mice by aminoguanidine or alagebrium treatment promoted elastin degradation, smooth muscle cell depletion, mural macrophage accumulation, and neoangiogenesis without affecting matrix metalloproteinases, C‐C motif chemokine ligand 2, or serum glucose concentration. Additionally, treatment with both inhibitors reversed suppression of diabetic aortic medial elastolysis by porcine pancreatic elastase in vitro.

Conclusions
Inhibiting AGE formation or AGE‐ECM cross‐linking enhances experimental AAAs in diabetes. These findings support the hypothesis that AGEs attenuate experimental AAAs in diabetes. These findings underscore the potential translational value of enhanced ECM cross‐linking as an inhibitory strategy for early AAA disease.
Association of Degree of Urbanization and Survival in Out‐of‐Hospital Cardiac Arrest
Authors: Gregers Mads Christian Tofte , Møller Sidsel Gamborg , Kjoelbye Julie Samsoe , Jakobsen Louise Kollander , Grabmayr Anne Juul , Kragh Astrid Rolin , Hansen Carolina Malta , Torp‐Pedersen Christian , Andelius Linn , Ersbøll Annette Kjær , Folke Fredrik 
Published: May 2023

Background
Survival from out‐of‐hospital cardiac arrest (OHCA) varies across regions. The aim of this study was to evaluate the association between urbanization (rural, suburban, and urban areas), bystander interventions (cardiopulmonary resuscitation and defibrillation), and 30‐day survival from OHCAs in Denmark.

Methods and Results
We included OHCAs not witnessed by ambulance staff in Denmark from January 1, 2016, to December 31, 2020. Patients were divided according to the Eurostat Degree of Urbanization Tool in rural, suburban, and urban areas based on the 98 Danish municipalities. Poisson regression was used to estimate incidence rate ratios. Logistic regression (adjusted for ambulance response time) tested differences between the groups with respect to bystander interventions and survival, according to degree of urbanization. A total of 21 385 OHCAs were included, of which 8496 (40%) occurred in rural areas, 7025 (33%) occurred in suburban areas, and 5864 (27%) occurred in urban areas. Baseline characteristics, as age, sex, location of OHCA, and comorbidities, were comparable between groups. The annual incidence rate ratio of OHCA was higher in rural areas (1.54 [95% CI, 1.48–1.58]) compared with urban areas. Odds for bystander cardiopulmonary resuscitation were lower in suburban (0.86 [95% CI, 0.82–0.96]) and urban areas (0.87 [95% CI, 0.80–0.95]) compared with rural areas, whereas bystander defibrillation was higher in urban areas compared with rural areas (1.15 [95% CI, 1.01–1.31]). Finally, 30‐day survival was higher in suburban (1.13 [95% CI, 1.02–1.25]) and urban areas (1.17 [95% CI, 1.05–1.30]) compared with rural areas.

Conclusions
Degree of urbanization was associated with lower rates of bystander defibrillation and 30‐day survival in rural areas compared with urban areas.
Antihypertensive Medication Regimens Used by US Adults With Hypertension and the Potential for Fixed‐Dose Combination Products: The National Health and Nutrition Examination Surveys 2015 to 2020
Authors: Derington Catherine G. , Bress Adam P. , Herrick Jennifer S. , Jacobs Joshua A. , Zheutlin Alexander R. , Berchie Ransmond O. , Conroy Molly B. , Cushman William C. , King Jordan B. 
Published: May 2023

Background
Fixed‐dose combination (FDC) antihypertensive products improve blood pressure control and adherence among patients with hypertension. It is unknown to what degree commercially available FDC products meet the current hypertension management prescription patterns in the United States.

Methods and Results
This cross‐sectional analysis of the National Health and Nutrition Examination Surveys 2015 to March 2020 included participants with hypertension taking ≥2 antihypertensive medications (N=2451). After constructing each participant's regimen according to antihypertensive classes used, we estimated the extent to which the 7 class‐level FDC regimens available in the United States as of January 2023 would match the regimens used. Among a weighted population of 34.1 million US adults (mean age, 66.0 years; 52.8% women; 69.1% non‐Hispanic White race and ethnicity), the proportions using 2, 3, 4, and ≥5 antihypertensive classes were 60.6%, 28.2%, 9.1%, and 1.6%, respectively. The 7 FDC regimens were among 189 total regimens used (3.7%), and 39.2% of the population used one of the FDC regimens (95% CI, 35.5%–43.0%; 13.4 million US adults); 60.8% of the population (95% CI, 57.0%–64.5%; 20.7 million US adults) were using a regimen not available as a class‐equivalent FDC product.

Conclusions
Three in 5 US adults with hypertension taking ≥2 antihypertensive classes are using a regimen that is not commercially available as a class‐equivalent FDC product as of January 2023. To maximize the potential benefit of FDCs to improve medication adherence (and thus blood pressure control) among patients taking multiple antihypertensive medications, use of FDC‐compatible regimens and improvements in the product landscape are needed.
Clinical Profile, Health Care Costs, and Outcomes of Patients Hospitalized for Heart Failure With Severely Reduced Ejection Fraction
Authors: Harrington Josephine , Sun Jie‐Lena , Fonarow Gregg C. , Heitner Stephen B. , Divanji Punag H. , Binder Gary , Allen Larry A. , Alhanti Brooke , Yancy Clyde W. , Albert Nancy M. , DeVore Adam D. , Felker G. Michael , Greene Stephen J. 
Published: May 2023

Background
Many patients with heart failure (HF) have severely reduced ejection fraction but do not meet threshold for consideration of advanced therapies (ie, stage D HF). The clinical profile and health care costs associated with these patients in US practice is not well described.

Methods and Results

We examined patients hospitalized for worsening chronic heart failure with reduced ejection fraction ≤40% from 2014 to 2019 in the GWTG‐HF (Get With The Guidelines‐Heart Failure) registry, who did not receive advanced HF therapies or have end‐stage kidney disease. Patients with severely reduced EF defined as EF ≤30% were compared with those with EF 31% to 40% in terms of clinical profile and guideline‐directed medical therapy. Among Medicare beneficiaries, postdischarge outcomes and health care expenditure were compared. Among 113 348 patients with EF ≤40%, 69% (78 589) had an EF ≤30%. Patients with severely reduced EF ≤30% tended to be younger and were more likely to be Black. Patients with EF ≤30% also tended to have fewer comorbidities and were more likely to be prescribed guideline‐directed medical therapy (“triple therapy” 28.3% versus 18.2%,
P
<0.001). At 12‐months postdischarge, patients with EF ≤30% had significantly higher risk of death (HR, 1.13 [95% CI, 1.08–1.18]) and HF hospitalization (HR, 1.14 [95% CI, 1.09–1.19]), with similar risk of all‐cause hospitalizations. Health care expenditures were numerically higher for patients with EF ≤30% (median US$22 648 versus $21 392,
P
=0.11).

Conclusions
Among patients hospitalized for worsening chronic heart failure with reduced ejection fraction in US clinical practice, most patients have severely reduced EF ≤30%. Despite younger age and modestly higher use of guideline‐directed medical therapy at discharge, patients with severely reduced EF face heightened postdischarge risk of death and HF hospitalization.
New Hypertension After Pregnancy in Patients With Heart Disease
Authors: Siu Samuel C. , Lee Douglas S. , Fang Jiming , Austin Peter C. , Silversides Candice K. 
Published: May 2023

Background
After pregnancy, patients with preexisting heart disease are at high risk for cardiovascular complications. The primary objective was to compare the incidence of new hypertension after pregnancy in patients with and without heart disease.

Methods and Results
This was a retrospective matched‐cohort study comparing the incidence of new hypertension after pregnancy in 832 patients who are pregnant with congenital or acquired heart disease to a comparison group of 1664 patients who are pregnant without heart disease; matching was by demographics and baseline risk for hypertension at the time of the index pregnancy. We also examined whether new hypertension was associated with subsequent death or cardiovascular events. The 20‐year cumulative incidence of hypertension was 24% in patients with heart disease, compared with 14% in patients without heart disease (hazard ratio [HR], 1.81 [95% CI, 1.44–2.27]). The median follow‐up time at hypertension diagnosis in the heart disease group was 8.1 years (interquartile range, 4.2–11.9 years). The elevated rate of new hypertension was observed not only in patients with ischemic heart disease, but also in those with left‐sided valve disease, cardiomyopathy, and congenital heart disease. Pregnancy risk prediction methods can further stratify risk of new hypertension. New hypertension was associated with an increased rate of subsequent death or cardiovascular events (HR, 1.54 [95% CI, 1.05–2.25]).

Conclusions
Patients with heart disease are at higher risk for developing hypertension in the decades after pregnancy when compared with those without heart disease. New hypertension in this young cohort is associated with adverse cardiovascular events highlighting the importance of systematic and lifelong surveillance.
The Cold War and Air Force Politics in Independent Nigeria (1960–1962)
Authors: Omeni Akali 
Published: May 2023

Abstract
The term “military” within the Nigerian context tends to be a misnomer for the Army, with the Navy and Air Force often at the scholarship margins. This article presents a corrective: it shifts the emphasis from the Nigerian Army within the historical discourse on politics and its impact on the military in Nigeria. The paper instead examines the Cold War political origins of the Nigerian Air Force (NAF) as an under-researched service branch of the Nigerian military. In 1962, after two years of political negotiations, Nigeria’s politicians shunned British overtures and opted for West German assistance in establishing an air force. In examining the Cold War political environment, including the actors and decision-making in the two years leading to that outcome, the article employs interview data and historical sources from the National Defence College Abuja and the UK National Archives, including communiqués, letters and other forms of official corpus.
An Evaluation of Diagnostic Tests for Aerodigestive Injuries in Penetrating Neck Trauma
Authors: Adra Amal , Brigode William , Bokhari Faran 
Published: May 2023

Assessment of aerodigestive injuries in penetrating neck trauma (PNT) is currently left up to the discretion of physicians which can result in a lot of confusion and unnecessary testing. This study was performed at a level 1 trauma center to assess the role of computed tomography arteriogram (CTA) in evaluating for aerodigestive injury in PNT. A total of 242 patients met criteria, with ages ranging from 7 to 86 years. Computed tomography arteriogram, EGD, esophagography, and bronchoscopy were classified into positive, negative, and indeterminate results. Computed tomography arteriogram was then further analyzed for violation of the carotid sheath, investing, pretracheal, and deep cervical fascias. Results showed a high sensitivity and NPV (100%) of CTA in assessing aerodigestive injury. Computed tomography arteriogram is a reliable first-line screening tool for aerodigestive injury. EGD appears more useful than esophagography at identifying esophageal injuries. Esophagography and bronchoscopy should be reserved to aid in injury management decision-making rather than as screening studies.
Epidemiology and Post-Discharge Resource Utilization of Isolated Traumatic Brain Injury in Geriatric Patients
Authors: Mlaver Eli , Codner Jesse , Solomon Gina , Todd S. Rob , Benjamin Elizabeth 
Published: May 2023

Benchmark data on traumatic brain injury (TBI) are potentially confounded by morbidity and rehabilitation needs associated with coincident extracranial injuries. Using data on isolated head injuries from 13 trauma centers in Georgia over 3 years, we studied the epidemiology and natural history of isolated TBI in geriatric vs non-geriatric patients in order to identify potential areas for quality improvement. We identified 8 512 patients, 3 895 of whom were geriatric. Geriatric patients had higher baseline comorbidity burden, mostly presented after ground level falls, had higher mortality despite equivalent ICU admission rates, and had higher rates of post-discharge resource utilization than non-geriatric counterparts. Geriatric patients are more likely to require post-discharge services and/or facility placement, regardless of pre-injury functional status. These data highlight the importance of streamlined protocols that place an early focus on post-discharge needs and goals of care, informed by cohort-specific prognosis data.
Hereditary angioedema in cardiac surgery: Perioperative management considerations for a rare disease
Authors: Adami Enrica Chiara , Magri Federica , Plotti Chiara , Renzi Stefania , Chiarini Giovanni , De Cicco Giuseppe 
Published: May 2023

Introduction Hereditary Angioedema is a rare disease caused by C1 esterase inhibitor deficiency leading to diffuse and potentially life-threatening oedema formation. Preventing attacks is critical, particularly for patients undergoing cardiac surgery. Case Report We report a case of a 71-years-old woman with a history of Hereditary Angioedema scheduled for open-heart surgery on Cardiopulmonary Bypass. Multidisciplinar teamwork and patient-targeted strategy were crucial to obtain a favorable outcome. Discussion Cardiac surgery is a major stressor for Angioedema attacks because of Complement cascade and inflammatory response activation leading to potential life-threatening oedema formation. In literature only few cases of complex open heart surgery under Cardiopulmonary Bypass are described. Conclusion Continuous updating and multidisciplinarity are key elements to manage patients with Hereditary Angioedema in cardiac surgery in order to reduce morbidity and mortality.
Climb up! Head up! Climbing improves posture in Parkinson's disease. A secondary analysis from a randomized controlled trial
Authors: Langer Agnes , Roth Dominik , Santer Agnes , Flotz Anna , Gruber Jakob , Wizany Laurenz , Hasenauer Sebastian , Pokan Rochus , Dabnichki Peter , Treven Marco , Zimmel Sarah , Schmoeger Michaela , Willinger Ulrike , Gassner Lucia , Maetzler Walter , Zach Heidemarie 
Published: May 2023

Objective To investigate the effect of sport climbing on a biomechanical marker of axial posture in patients with Parkinson's disease, as well as its association with age, body mass index and health-related quality-of-life outcome measures. Design Pre-planned secondary analysis of our randomized controlled, semi-blind trial (unblinded patients, blinded assessors) comparing sport climbing to unsupervised exercise. Setting Single-centre study conducted at the Department of Neurology of the Medical University of Vienna, Austria. Participants Forty-eight Parkinson's disease patients (aged 64 ± 8 years, Hoehn & Yahr stage 2–3) were included. Intervention Sport climbers ( n = 24) followed a 12-week, 90 min/week supervised top-rope sport climbing course in an indoor climbing gym. The unsupervised training group ( n = 24) independently followed the ‘European Physiotherapy Guidelines for Parkinson's Disease’ and World Health Organization recommendations for an active lifestyle for 12 weeks. Main measures Posture was assessed with the horizontal distance of the seventh cervical vertebra to the wall at baseline and after the intervention. Results Participating in the sport climbing group significantly predicted the biomechanical marker of axial posture ( P = 0.044). The improvement in the biomechanical marker did not affect the quality of life, depression, fatigue, physical activity or fear of falling. Participants in the sport climbing group showed a significantly decreased horizontal distance of the seventh cervical vertebra to the wall after the intervention (−1.7 cm (95%CI [−2.6, −0.8]). In the unsupervised training group, no difference was found (−0.5 cm; 95%CI −1.3, 0.2]). Conclusions We conclude that sport climbing improves a biomechanical marker of axial posture in Parkinson's disease.
Dual-energy CT iodine overlay improves efficiency of oral contrast leak assessment
Authors: Hinen Shaun P , Griffith Joseph P , Chamberlin Jordan , Waltz Jeffrey , Kocher Madison , Krull Veronica , Young Tristan , Litvin Cara B , Varga-Szemes Akos , Hardie Andrew D 
Published: May 2023

BackgroundEvaluation for gastrointestinal leak is a frequent imaging indication, and dual-energy computed tomography (DECT) with oral or rectally administered contrast can be used to improve efficiency and diagnostic confidence.PurposeTo assess the value of the DECT iodine overlay (IO) reconstruction as a stand-alone image set compared to routine CT in assessing oral or rectal contrast leak from the gastrointestinal system.Material and MethodsA blinded, retrospective audit study was performed by three readers who each interpreted 50 studies performed for assessment of oral or rectal contrast leak that were acquired using DECT. Each reader independently assessed both the routine CT images and the images of the reconstructed IO for contrast leak in random order with a six-week “wash-out period” between readings. Clinical follow-up provided the reference standard. Readers recorded the presence/absence of a leak, diagnostic confidence, image quality score, and interpretation time for each image set.ResultsPooled data for overall accuracy in identification of a leak increased from 0.81 (95% confidence interval [CI]=0.74–0.87) for routine CT to 0.91 (95% CI=0.85–0.95) with IO, and the area under the curve (AUC) was significantly higher for IO than routine CT ( P = 0.015). Readers required significantly less time to interpret IO than routine CT (median improvement of 12.5 s per image using pooled data; P < 0.001) while maintaining diagnostic confidence and perceived image quality.ConclusionUse of DECT IO reconstructions for identification of oral or rectal contrast leak requires less time to interpret than routine CT with improved accuracy and maintained diagnostic confidence and perceived image quality.