bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of trading hours extensions on foreign exchange volatility: intraday evidence from the Moscow exchange
Authors: Frömmel Michael , Kadioglu Eyup 
Published: July 2023

AbstractUsing transaction-level tick-by-tick data of same- and next-day settlement of the Russian Ruble versus the US Dollar exchange rate (RUB/USD) traded on the Moscow Exchange Market during the period 2005–2013, we analyze the impact of trading hours extensions on volatility. During the sample period, the Moscow Exchange extended trading hours three times for the same-day settlement and two times for the next-day settlement of the RUB/USD rate. To analyze the effect of the implementations, various measures of historical and realized volatility are calculated for 5- and 15-min intraday intervals spanning a period of three months both prior to and following trading hours extensions. Besides historical volatility measures, we also examine volume and spread. We apply an autoregressive moving average-autoregressive conditional heteroscedasticity (ARMA-GARCH) model utilizing realized volatility and a trade classification rule to estimate the probability of informed trading. The extensions of trading hours cause a significant increase in both volatility and volume for further analyzing the reasons behind volatility changes. Volatility changes mostly occur after the opening of the market. The length of the extension has a significant positive effect on realized volatility. The results indicate that informed trading increased substantially after the opening for the rate of same-day settlement, whereas this is not observed for next-day settlement. Although trading hours extensions raise opportunities for more transactions and liquidity in foreign exchange markets, they may also lead to higher volatility in the market. Furthermore, this distortion is more significant at opening and midday. A potential explanation for the increased volatility mostly at the opening is that the trading hours extension attracts informed traders rather than liquidity providers.
Experience with transesophageal echocardiography for mitral valve plasty in the remote stage after esophagectomy with gastric tube reconstruction via the posterior mediastinal route
Authors: Sato Yuri , Tokita Takaharu , Saito Junichi , Hirota Kazuyoshi 
Published: July 2023

AbstractA 69-year-old male patient with mitral valve prolapse was scheduled for mitral valve plasty. Sixteen years earlier, he had undergone right open thoracotomy for esophageal cancer with subtotal esophagectomy, cervicothoraco-abdominal three-region dissection, posterior mediastinal tube reconstruction, and cervical anastomosis. Postoperatively, the patient had a treatment- and recurrence-free course, and an upper gastrointestinal endoscopy performed 2 years prior revealed no abnormality. We scheduled a transesophageal echocardiography for mitral valve surgery. We attempted to insert the probe but felt resistance at the height of the mid-thoracic region, and the image quality was poor, so we abandoned the intraoperative diagnosis. The surgery was performed as planned, and when the probe was manipulated again at the time of cardiopulmonary withdrawal, the mitral valve could be observed. The mitral valve was judged to be sufficiently repaired, and the surgery was terminated. There were no complications associated with transesophageal echocardiography.
Jeonju declaration on Korean-food: creating value and sustainability
Authors: Cha Youn-Soo 
Published: July 2023

AbstractJeonju was selected as Korea’s only UNESCO City of Gastronomy in 2012. Jeonju food has been attracting attention as ‘sincere foods’ that is likened to a mother’s cooking and bricolage foods since ancient times. Jeonju is a representative of K-food as a city with the recognition of being a ‘hometown of taste’ and the ‘pride of taste’ in Jeolla-do. The global interest in K-food is based on a ‘healthy image’, and it is expected that the international interest in K-food will continue to rise in the future due to its health benefits. K-food contributes to the promotion of human health based on scientific research on its various aspects such as ingredients, recipes, and diet composition. The fact that K-food contains a lot of vegetables and fermented foods can be considered as one of the factors that can respond to the climate crisis. The Jeonju Declaration gather numerous values to lay the foundation for the direction in which K-food should be served. Therefore, this year 2022, to mark the 10th anniversary of the UNESCO City of Gastronomy, Jeonju City specified the K-food hub and declared the following ‘Jeonju Declaration on K-Food: Creating Value and Sustainability’ on June 16, 2022. Declaring that Jeonju food is K-food, we intend to promote the continuous globalization of K-food by creating various values such as national, historical/culture, commercial/industrial, and health/nutritional values.
Sustainability of K-Food: focused on the change in the health values of K-Food
Authors: Moon Hye-Jung , Cha Youn-Soo 
Published: July 2023

AbstractThe importance of culture and interest in K-culture due to the development of online Mediterraneania such as social media have increased curiosity about K-Food, which contains Korean traditions and cultures. It will be necessary to establish the identity and value of K-Food in order to continue it, which is in global attention. Therefore, this study reviewed the definition, tradition, and health values of K-Food from the past to the present for the sustainability of K-Food in the global era. K-Food has been constantly influenced by geography, climate, religion, ideology, and neighboring countries throughout Korea's 5,000-year history, but has maintained Korea's unique and creative dietary habits and traditions. K-Food is an individual Korean dish, bapsang, constituting K-diet, and K-diet is a concept that combines K-Food and K-culture. Korean traditional fermented food, one of the K-Foods, and Korean dietary patterns have been reported to improve body weight, gastrointestinal health, diabetes, hypertension, dyslipidemia, and cognitive function. In addition, K-Food has a similar dietary pattern and nutritional value to the healthy Mediterranean diet. In conclusion, the sustainability of K-Food in the era of globalization requires continuous education to preserve traditions and culture, scientific research on health functions, and localization research so that it can be easily applied in other countries.
Once again... breakthrough cancer pain: an updated overview
Authors: Mercadante Sebastiano 
Published: July 2023

Abstract
Breakthrough cancer pain (BTcP) is a complex and variegate phenomenon that may change its presentation during the course of patients’ disease in the same individual. An appropriate assessment is fundamental for depicting the pattern of BTcP. This information is determinant for a personalized management of BTcP. The use of opioids as needed is recommended for the management of BTcP. There are several options which should be chosen according to the individual pattern of BTcP. In general, a drug with a short onset and offset should be preferred. Although oral opioids may still have specific indications, fentanyl products have been found to be more rapid and effective. The most controversial point regards the opioid dose to be used. The presence of opioid tolerance suggests to use a dose proportional to the dose used for background analgesia. In contrast, regulatory studies have suggested to use the minimal available dose to be titrated until the effective dose. Further large studies should definitely settle this never ended question.
Elective disciplines – an important component in the formation of professinal competences of future doctors – pediatric dentists
Authors: Bidenko Natalia , Ostapko Olena , Koval Olga 
Published: July 2023

The article investigates actual issues of introduction of elective disciplines to the educational process of dental students. According to the changes in the political, economic and social spheres of our country, the labor market requires the training of highly skilled specialists who have a high level of knowledge, skills and competences in a particular industry, could make decision in standard and non-standard situations, bear responsibility for them in the professional activity. That is why the importance issue of the development and formation of today’s education is the use of a competence approach. Elective disciplines have an important role in the formation of the professional competences of future doctors and dentists.
The purpose of the study was to reveal the expediency of teaching elective disciplines to students of the Faculty of Dentistry using the example of an elective discipline “Modern technologies in pediatric dentistry” for students of 5th student year.
The blocks of elective disciplines that form a variable component of the Educational and Professional program of Dentistry are characterized. The content of the elective discipline “Modern technologies in pediatric dentistry” for students of the 5th year of the Faculty of Dentistry of Bogomolets National Medical University is analyzed. Thematic plans of lectures and practical lessons in the discipline are presented. It is emphasized, that the purpose of studying this elective discipline is the formation of professional competences necessary for high-quality dental treatment of children, including under general anesthesia. The elective discipline “Modern technologies in pediatric dentistry” was introduced into the educational process in 2022/23 acadrmic year and received favorable reviews from students. Further research involves an anonymous survey of students and teachers, interviews with graduates and employers with the aim of improving the content of electives disciplines and the level of their teaching at the departments
Nationwide Screening Practices of Tamoxifen Retinopathy in South Korea: a Population-Based Cohort Study
Authors: Ahn Seong Joon , Kim Jiyeong , Kim Ji Hong , Kwon Hyeon Yoon 
Published: July 2023

Abstract
In this population-based cohort study, we investigated the nationwide screening practices and trends in tamoxifen retinopathy in South Korea using national health insurance claims data. A total of 43,848 patients who started tamoxifen therapy between 2015 and 2020 and had no prior ophthalmic diseases or other conditions requiring screening for retinopathy were included. The annual numbers of tamoxifen users and new initiators of tamoxifen therapy were assessed. The screening examinations were separated into baseline (first ophthalmic examination after tamoxifen administration) and subsequent monitoring examinations. The timing and modalities for the baseline and subsequent monitoring examinations performed between 2015 and 2021 were assessed in tamoxifen users. The annual number of tamoxifen users increased over the study period from 54,056 in 2015 to 81,720 in 2021. The number of patients who underwent ophthalmic examination after tamoxifen administration was 8,961 (20.4%). Baseline screening was performed in 6.5% of patients within 1 year of use, and subsequent monitoring was performed in 27.8% of patients who underwent baseline screening. The mean number of monitoring examinations per year was 0.68 ± 0.45. Funduscopy/fundus photography was most commonly performed for baseline screening and subsequent monitoring (99.0% and 98.6%, respectively), while optical coherence tomography was performed only in 21.9% and 29.6% of baseline and monitoring examinations, respectively. Although the annual percentage of patients receiving a baseline examination within 1 year gradually increased over time, those with subsequent monitoring performed within 1 year were similar over the study period. Our finding, appropriate screening in a small proportion of patients receiving tamoxifen, suggests the need to promote awareness among healthcare professionals and develop a standardized approach for screening tamoxifen retinopathy.
Comparative analysis of low-altitude magnetic survey sensitivity using unmanned aerial vehicles and land magnetic survey
Authors: Snegirev N. V. , Gachenko S. V. , Parshin A. V. 
Published: July 2023

The subject of the study is the problem of the decline degree of the information content of geophysical data when switching from land surveys to low-altitude geophysical survey using unmanned aerial vehicles. The research involves a comparative analysis of the information content of the unmanned aerial vehicle survey results and those of the land magnetic survey. The conducted research allowed to present the observed values of the magnetic field obtained by both survey methods within the same area as well as the final information products in the form of the results of filtering and three-dimensional data inversion. It is shown that visual analysis of maps of the full vector of magnetic field strength gives the impression of a lower information content of magnetic survey performed by unmanned aerial vehicles. However, the data having been processed create final information products of identical information content. This concerns both the results of three-dimensional modeling of the effective magnetic susceptibility, and maps and plots of the anomalous magnetic field after filtering in a sliding window. The negative impact of geological interference from morainic deposits on ground data is also shown. Local magnetic anomalies based on unmanned aerial vehicle survey results can confidently correlate with land survey anomalies, whereas the data collected during low-altitude aeromagnetic survey using unmanned aerial vehicles have a lower error probability. The conclusions refer to a specific case and cannot be unambiguously applied to any geological situation, however, the authors believe in the typicality of this example.
An increase in temperature under the shared socioeconomic scenarios in the Volta River Basin, West Africa: implications for economic development
Authors: Limantol Andrew Manoba , Larbi Isaac , Dotse Sam-Quarcoo , Okafor Gloria Chinwendu , Asare-Nuamah Peter , Frimpong Louis Kusi , Alhassan Abdul-Rauf Malimanga , Angmor Emmanuel , Joel Premkumar Jilly Philippa , Lutterodt George , Asiamah Theodora Akweley , Atta-Darkwa Thomas , Kumi Naomi , Prempeh Nana Agyemang 
Published: July 2023

Abstract

This study examined the temperature variations in West Africa's Volta River Basin (VRB) from 2021 to 2050 in comparison to the historical period (1985–2014) under two Shared Socioeconomic Pathway Scenarios (SSP2-4.5 and SSP5-8.5). Datasets from three Global Climate Models (GCMs) of the sixth Coupled Model Intercomparison Project (CMIP6) were used. The GCMs and their ensemble were evaluated on a monthly scale. The study used the ensemble mean to analyse the changes in annual and monthly temperature over the Sahel, Savannah, Guinea Coast, and the entire Volta basin. The results demonstrate the individual GCMs reproduced the observed temperature pattern at the VRB, though with some overestimations, but the ensemble mean indicated a better representation of the observed temperature. A warming trend in the basin is projected under both climate scenarios, with higher temperatures projected under SSP5-8.5 compared to SSP2-4.5 in all three zones. The mean annual temperature is projected to increase by 0.8 and 1.0 °C, with a statistically increasing trend under SSP2-4.5 and SSP5-8.5, respectively. Without a doubt, high temperatures, if unchecked, can erupt into resource conflict among the competing interest groups, thereby affecting the achievement of economic development at the VRB.
Neuroblastoma chemoimmunotherapy: current results and application prospects
Authors: Ivanov N. S. , Kachanov D. Yu. , Shamanskaya T. V. 
Published: July 2023

Neuroblastoma (NB) is the most common extracranial solid tumor of childhood affecting children from 0 to 14 years old. Despite the achievements of modern multimodal risk-adapted therapy, the prognosis in patients with high-risk NB remains unfavorable. Numerous research groups have shown that a good response achieved at the time of completion of the induction stage of therapy in this subgroup of patients correlates with survival rates. Thus, improving the response to induction therapy may be a potential mechanism for improving long-term survival rates. Over the past few decades, traditional approaches to cancer therapy have undergone a radical revolution, largely due to the development and implementation of the immunotherapy method. It is known that combined antitumor therapy is superior to monotherapy and is one of the tools for overcoming heterogeneous drug resistance. A vast number of preclinical studies has shown that GD2-directed monoclonal antibodies (mAbs) are able to enhance the cytostatic effects of chemotherapeutic drugs, which has become a promising model for clinical studies of various chemoimmunotherapy regimens, which have demonstrated convincing evidence of safety and an acceptable toxicity profile with an encouraging effect on objective response rates, overall and event-free survival in both patients with recurrent, refractory NB, and primary patients of the high-risk group.The article discusses fundamental ideas about the synergistic interaction of GD2-directed mAbs in combination with cytostatic agents, the role of response to the induction stage of therapy and prospects for the use of induction chemoimmunotherapy as a method of improving postinduction response, event-free and overall survival in patients with NB.
Functional Roles of the lncRNA MALAT1 in Glioma
Authors: Moftakhar Arya , Najafi Sajad , Anbiyaee Omid , Farzaneh Maryam , Khoshnam Seyed Esmaeil 
Published: July 2023

Abstract:
Gliomas are a group of brain cancers with various clinical and biological features, and they
are mostly malignant. Progressions in therapy approaches, comprising radiotherapy, chemotherapy,
and surgery, have not been so considerable in the prognosis of glioma cases. Recently, long noncoding
RNAs (lncRNAs) have been found with putative regulatory roles in gene expression, epigenetic
regulation, neurogenesis, cell cycle, and cellular transportation. The lncRNA Metastasis Associated
Lung Adenocarcinoma Transcript 1 (MALAT1) is frequently reported to be associated with multiple
disorders, such as various types of cancers. Upregulation of MALAT1 is detected in different
tumours, including glioma, and functional analyses reveal it affects malignant features of cancer cells
like proliferation, migration, invasion and apoptosis. MALAT1 impacts those features by modulating
various epigenetic histones, hormones, growth factors, and transcription factors. Therefore, this
lncRNA can be regarded as a potent therapeutic target for glioma. In this review, we summarized the
functional roles of MALAT1 in glioma.
Physalin B Reduces Tau Phosphorylation and Cell Apoptosis in HEK293 Cells
by Activating FoxO1
Authors: Zhang Wei , Shi Yating , Lv Mingti , Zhang Yimin , Ren Wei , Shi Ruling , Wang Hecheng , Shan Linlin 
Published: July 2023

Background:
Physalin B (PB) is one of the main active compounds of Solanaceae plants, with a wide range of biological activities. PB reportedly has the potential to treat Alzheimer’s disease (AD).

Objective:
In this study, we investigated the effect of PB on Tau phosphorylation and cell apoptosis using Tau-expressing HEK293 cells (HEK293/Tau) as a cellular model.

Methods:
The optimum concentration of PB to treat HEK293/Tau cells was determined using the CCK-8 assay. Additionally, the expression of FoxO1, Tau-5, p-Tau (T231, S262, and S404), ERK, p-ERK, GSK-3β, and p-GSK-3β was detected using western blotting to determine the effect of PB on Tau phosphorylation. The apoptosis rate was detected using flow cytometry, and the expression of Bax and Bcl-2 was detected using western blotting and verified using real-time quantitative polymerase chain reaction (RT-qPCR). Moreover, cells were transfected with FoxO1 siRNA to downregulate FoxO1 expression, and the expression of the above-mentioned proteins was detected to verify the effect of PB on Tau phosphorylation and cell apoptosis.

Results:
After 24 h of PB treatment, the phosphorylation levels of Tau at S404, S262, and T231 sites decreased significantly, and the activities of GSK-3β and ERK were inhibited. PB also reduced cell apoptosis by reducing the expression of Bax and increasing the expression of Bcl-2. In addition, PB decreased Tau phosphorylation and cell apoptosis by upregulating FoxO1.

Conclusion:
The natural compound PB exhibited a protective effect in the AD cell model by increasing FoxO1 expression and reducing Tau phosphorylation and cell apoptosis.
Extravesical ureteral ectopia from an iliac dystopic hypoplastic left kidney in a girl
Authors: Sizonov V. V. , Shidaev A. Kh-A. , Makarov A. G. , Zhulia V. R. , Vlasov S. N. , Filonenko А. V. 
Published: July 2023

Extravesical ureteral ectopia (EUE) is a rare cause of urinary incontinence (UI) in girls. In 80% of cases, ectopia is associated with ureteral duplication. We are reporting a case of a 17-year-old girl with UI by EUE from an iliac dystopic hypoplastic left kidney. The girl received outpatient treatment for UI and left kidney agenesia since the age of 5, when her parents for the first time noticed the UI with background normal urination. The child underwent a complete range of medical tests: CT, cystoscopy, renal nuclear scan, uroflowmetry, ureteral cystometry and profilometry. Although the examination revealed no proof of renal tissue existence on the left side, a pad test with a dye was performed to exclude an EUE. The test gave a positive result, which determined further diagnostic search. Vascular CT was performed and made it possible to visualize a severely hypoplastic left kidney dystopic towards the iliac vessels. Laparoscopic nephrectomy was performed and UI manifestations were corrected. Availability of a wide range of visualisation methods in the urologist's toolkit does not always allow to verify hypoplastic renal dystopia when the kidney is drained by a ureter with an extravesical ectopic orifice. When a reasonable suspicion of an EUE is combined with lack of information about its location and dimensions after visualizing tests, a pad test with a dye appears appropriate prior to a diagnostic laparoscopy in our opinion. Once the UU is confirmed by the dye test results, further diagnostic search using laparoscopic access is justified and can be transformed into a treatment procedure if the kidney is revealed.