bluuebunny/crossref_metadata_2025_split huggingface dataset:
The high voltage system the novel MPGD-based photon detectors of
COMPASS RICH-1 and its development towards a scalable HVPSS for
MPGDs
Authors: Bressan A. , Carrato S. , Chatterjee C. , Cicuttin A. , Crespo M.L. , D'Ago D. , Dalla Torre S. , Dasgupta S. , Ballina Escobar M.G. , Samayoa W.F. , García Ordóñez L. , Gregori M. , Hamar G. , Kosoveu A. , Levorato S. , Mannatunga K. , Martin A. , Tessarotto F. , Triloki  , Valinoti B. 
Published: July 2023

Abstract
The COMPASS RICH-1 detector underwent major upgrade in 2016 with the installation of four
novel MPGD-based photon detectors. They consist of large-size hybrid MPGDs with multi-layer
architecture composed of two layers of Thick-GEMs and bulk resistive Micromegas. A dedicated high
voltage power supply system, realized with commercial devices, has been put in operation to
protect the detectors against errors by the operator, monitor and log voltages and currents at a 1 Hz rate, and automatically react to detector misbehavior; it includes also the HV compensation for
the detector gas pressure and temperature variations.

The needs posed to the high voltage
power supply systems by the operation of Micro Pattern Gaseous Detectors pushed the development of
a novel single channel HV system able to overcome the performance of the commercial devices in
terms of high-resolution diagnostic features and intelligent dynamic voltage control. In this talk
the COMPASS HV system and its performance are illustrated, as well as the stability of the novel
MPGD-based photon detectors during the physics data taking at COMPASS. The performance of the
novel single channel power supply system when connected to a single photon Micro Pattern Gaseous
Detector is presented in realistic working condition during a test beam with the preliminary
results of multiple channels operation.
Deciphering the sensitivity of urban canopy air temperature to anthropogenic heat flux with a forcing-feedback framework
Authors: Wang Linying , Sun Ting , Zhou Wenyu , Liu Maofeng , Li Dan 
Published: July 2023

Abstract
The sensitivity of urban canopy air temperature (

T
a

) to anthropogenic heat flux (

Q

A
H

) is known to vary with space and time, but the key factors controlling such spatiotemporal variabilities remain elusive. To quantify the contributions of different physical processes to the magnitude and variability of

Δ

T
a

/

Δ

Q

A
H

(where

Δ

represents a change), we develop a forcing-feedback framework based on the energy budget of air within the urban canopy layer and apply it to diagnosing

Δ

T
a

/

Δ

Q

A
H

simulated by the Community Land Model Urban over the contiguous United States (CONUS). In summer, the median

Δ

T
a

/

Δ

Q

A
H

is around 0.01

K

W

m

−

2

−
1

over the CONUS. Besides the direct effect of

Q

A
H

on

T
a

, there are important feedbacks through changes in the surface temperature, the atmosphere–canopy air heat conductance (

c
a

), and the surface–canopy air heat conductance. The positive and negative feedbacks nearly cancel each other out and

Δ

T
a

/

Δ

Q

A
H

is mostly controlled by the direct effect in summer. In winter,

Δ

T
a

/

Δ

Q

A
H

becomes stronger, with the median value increased by about 20% due to weakened negative feedback associated with

c
a

. The spatial and temporal (both seasonal and diurnal) variability of

Δ

T
a

/

Δ

Q

A
H

as well as the nonlinear response of

Δ

T
a

to

Δ

Q

A
H

are strongly related to the variability of

c
a

, highlighting the importance of correctly parameterizing convective heat transfer in urban canopy models.
Comparison of Brownian jump and Brownian bridge resetting in search for Gaussian target on the line and in space
Authors: Pinsky Ross G 
Published: July 2023

Abstract
We consider a Brownian searcher with diffusion coefficient D in d-dimensions, for

d
=
1
,
2
,
3

, that starts from the origin and searches for a random target with a centered-Gaussian distribution. The searcher is also equipped with a resetting mechanism that resets the searcher back to the origin. We consider three different resetting mechanisms. One is a Poissonian reset with rate r whereby at the reset time the searcher instantaneously jumps back to the origin, one is a periodic reset with period T whereby at the reset time the searcher instantaneously jumps back to the origin, and one is a Brownian bridge reset with period T, whereby the Brownian motion is conditioned to return to the origin at time T. Unlike the first two search processes, this last one has continuous paths. For d = 1 and d = 3, we obtain analytic formulas for the expected time to locate the random target, and minimize them over r or T, as the case may be. In one dimension, this expected time scales as

σ
2

D

, which is not surprising, but in three dimensions we obtain the anomalous scaling

σ
3

D

. We compare the relative efficiencies of the three search processes. In two dimensions, we show that the expected time scales as

σ
2

D

for the Poissonian reset mechanism.
Density of states of a 2D system of soft-sphere fermions by path integral Monte Carlo simulations
Authors: Filinov V , Levashov P , Larkin A 
Published: July 2023

Abstract
The Wigner formulation of quantum mechanics is used to derive a new path integral representation of quantum density of states (DOSs). A path integral Monte Carlo approach is developed for the numerical investigation of DOSs, internal energy and spin-resolved radial distribution functions for a 2D system of strongly correlated soft-sphere fermions. The peculiarities of the DOSs and internal energy distributions depending on the hardness of the soft-sphere potential and particle density are investigated and explained. In particular, at high enough densities the DOSs rapidly tends to a constant value, as for an ideal system of 2D fermions.
Relationships between economic development and resident environmental behavior and participation in areas with different economic and similar natural and cultural conditions
Authors: Wu Junli , Gao Guijuan , Zhang Bing , Yang Zhongyi 
Published: July 2023

Abstract
Economic development level (EDL) cannot completely explain environmental behavior and participation (EBP) patterns as many other factors affect environmental performances, and the conflict of ‘Maslow’s Hierarchy Needs model’ or ‘Affluence hypothesis’ and ‘Challenge-response Model’ hypothesis has been continuously discussed. In the present study, a standardized two-dimensional array (STDA) model is employed to deliberate on the EDL-EBP relationship in different sub-groups with the highest ($21389.08) and the lowest ($5216.41) average capita GDPs in Guangdong Province, China. This is the first attempt to investigate the relationships between the regional EDL represented by capita GDP and public environmental behaviors represented by actual resident’s resource consumption, pollution emission and environmental participation in areas with similar natural and cultural condition, and an Environmental Effort Indicator (EEI) is established based on the STDA model. The results show that (1) the STDA model is applicable in distinguishing resident’s EBPs of 20 prefecture-level cities (PLCs) of Guangdong Province with rather different EDLs; (2) the relationship of EDL-EBP is not liner pattern and is behavior- and region-specific; (3) public participation plays an important role that is most decisive to the EEI; (4) the V-shaped EDL-EEI relationships can be explained each other with the EKC model. The formation of resident’s good environmental habits would be a long-term process and environmental education is a key way to accelerate the process and to maintain sustainable developments of the nature and human society.
Cancer-associated fibroblasts promote cancer stemness by inducing expression of the chromatin-modifying protein CBX4 in squamous cell carcinoma
Authors: Fisher Matthew L , Balinth Seamus , Hwangbo Yon , Wu Caizhi , Ballon Carlos , Goldberg Gary L , Mills Alea A 
Published: July 2023

Abstract
The chromobox-containing protein CBX4 is an important regulator of epithelial cell proliferation and differentiation, and has been implicated in several cancer types. The cancer stem cell (CSC) population is a key driver of metastasis and recurrence. The undifferentiated, plastic state characteristic of CSCs relies on cues from the microenvironment. Cancer-associated fibroblasts (CAFs) are a major component of the microenvironment that can influence the CSC population through the secretion of extracellular matrix and a variety of growth factors. Here we show CBX4 is a critical regulator of the CSC phenotype in squamous cell carcinomas of the skin and hypopharynx. Moreover, CAFs can promote the expression of CBX4 in the CSC population through the secretion of interleukin-6 (IL-6). IL-6 activates JAK/STAT3 signaling to increase ∆Np63α—a key transcription factor that is essential for epithelial stem cell function and the maintenance of proliferative potential that is capable of regulating CBX4. Targeting the JAK/STAT3 axis or CBX4 directly suppresses the aggressive phenotype of CSCs and represents a novel opportunity for therapeutic intervention.
Arterial hypertension in patients with takotsubo syndrome: prevalence, long-term outcome, and secondary preventive strategies: a report from the Takotsubo Italian Network register
Authors: Silverio Angelo , Bossone Eduardo , Parodi Guido , Scudiero Fernando , Di Maio Marco , Vriz Olga , Bellino Michele , Zito Concetta , Provenza Gennaro , Iuliano Giuseppe , Cristiano Mario , Novo Giuseppina , Mauro Ciro , Rigo Fausto , Innelli Pasquale , Salerno-Uriarte Jorge , Cameli Matteo , Tremiterra Giuliana , Vecchione Carmine , Antonini-Canterin Francesco , Galasso Gennaro , Citro Rodolfo 
Published: July 2023

Abstract

Aims
The aim of this study was to investigate the long-term outcome of takotsubo syndrome (TTS) patients with and without hypertension (HT) and to evaluate the effectiveness of treatment with beta-blockers (BBs) and/or renin–angiotensin–aldosterone system inhibitors (RAASi).

Methods and results
The study population includes a register-based, multicentre cohort of consecutive patients with TTS, divided into two groups according to the history of HT. Further stratification was performed for BB/RAASi prescription at discharge. The primary outcome was the composite of all-cause death and TTS recurrence at the longest available follow-up. The propensity score weighting technique was used to account for potential confounding. In the overall population (903 patients, mean age 70 ± 11 years), HT was reported in 66% of cases. At a median 2-year follow-up, there was no difference in the risk of the primary composite outcome between patients with and without HT. The adjusted Cox regression analysis showed a significantly lower risk for the primary outcome [adjusted hazard ratio (aHR): 0.69; 95% confidence interval (CI): 0.49–0.99] in patients who received BB vs. those who did not. Renin–angiotensin–aldosterone system inhibitors treatment was not associated with the primary study outcome. The lower risk for the primary outcome with BB treatment was confirmed in patients with HT (aHR: 0.37; 95% CI: 0.24–0.56) but not in patients without (aHR: 1.83; 95% CI: 0.92–3.64; Pinteraction &lt; 0.001).

Conclusion
In this TTS study, HT did not affect the long-term risk of adverse events but increased the probability of benefit from BB treatment after discharge. Owing to the favourable outcome impact of BB prescription in TTS patients with HT, a tailored pharmacological therapy should be considered in this cohort.
Clusters of acidic and hydrophobic residues can predict acidic transcriptional activation domains from protein sequence
Authors: Kotha Sanjana R , Staller Max Valentín 
Published: July 2023

Abstract
Transcription factors activate gene expression in development, homeostasis, and stress with DNA binding domains and activation domains. Although there exist excellent computational models for predicting DNA binding domains from protein sequence, models for predicting activation domains from protein sequence have lagged, particularly in metazoans. We recently developed a simple and accurate predictor of acidic activation domains on human transcription factors. Here, we show how the accuracy of this human predictor arises from the clustering of aromatic, leucine, and acidic residues, which together are necessary for acidic activation domain function. When we combine our predictor with the predictions of convolutional neural network (CNN) models trained in yeast, the intersection is more accurate than individual models, emphasizing that each approach carries orthogonal information. We synthesize these findings into a new set of activation domain predictions on human transcription factors.
Association Between the Healthy Lifestyle Index and Risk of Multimorbidity in the Women’s Health Initiative
Authors: Peila Rita , Xue Xiaonan , Shadyab Aladdin H , Wactawski-Wende Jean , Espeland Mark A , Snetselaar Linda G , Saquib Nazmus , Ikramuddin Farha , Manson JoAnn E , Wallace Robert B , Rohan Thomas E 
Published: July 2023

Abstract

Background
Multimorbidity, defined as the presence of 2 or more chronic health conditions, is increasingly common among older adults. The combination of lifestyle characteristics such as diet quality, smoking status, alcohol intake, physical activity (PA), sleep duration, and body fat as assessed by body mass index (BMI) or waist circumference, and risk of multimorbidity are not well understood.

Objectives
We investigated the association between the healthy lifestyle index (HLI), generated by combining indicators of diet quality, smoking, alcohol, PA, sleep amount, and BMI, and risk of multimorbidity, a composite outcome that included cardiovascular disease (CVD), diabetes, cancer, and fracture.

Methods
We studied 62 037 postmenopausal women aged 50–79 years at enrollment in the Women’s Health Initiative, with no reported history of CVD, diabetes, cancer, or fracture at baseline. Lifestyle characteristics measured at baseline were categorized and a score (0–4) was assigned to each category. The combined HLI (0–24) was grouped into quintiles, with higher quintiles indicating a healthier lifestyle. Multivariable adjusted estimates of hazard ratios (HRs) and 95% confidence intervals (95% CIs) for the risk of developing multimorbidity were obtained using Cox proportional hazard models.

Results
Over an average follow-up period of 16.3 years, 5 656 women developed multimorbidity. There was an inverse association between the HLI levels and risk of multimorbidity (compared to the HLI_1st quintile: HR_2nd quintile = 0.81 95% CI 0.74–0.83, HR_3rd quintile = 0.77 95% CI 0.71–0.83, HR_4th quintile = 0.70 95% CI 0.64–0.76, and HR_5th quintile = 0.60 95% CI 0.54–0.66; p trend &lt; .001). Similar associations were observed after stratification by age or BMI categories.

Conclusions
Among postmenopausal women, higher levels of the HLI were associated with a reduced risk of developing multimorbidity.
Quantification of Chlorate and Perchlorate in a Broad Range of Food Commodities, Including Baby Food, Nutritional Formulas, and Ingredients by LC-MS/MS: First Action AOAC 2022.06
Authors: Huertas-Pérez José Fernando , Mottier Pascal , Konings Erik , Baslé Quentin , Tan Shi Ying , Kopeć-Durska Monika , Zawada Patrycja , Griffin Ashley , Sánchez-Calderón María Guadalupe , Silva-Robledo Juan Pablo , Rubio Lisette 
Published: July 2023

Abstract

Background
Chlorate is an effective herbicide, but also a byproduct of chlorinating agents used to disinfect water, which is one of the reasons why it is regularly found in food. Perchlorate is a ubiquitous contaminant, which is naturally occurring in the environment but also released from anthropogenic sources such as the industrial use of certain natural fertilizers. Chlorate affects the hematological system, and perchlorate the thyroid.

Objective
Implement and validate a simple and robust analytical method for the accurate determination of chlorate and perchlorate in baby food, infant and adult formulas, and ingredients thereof, which is suited for its application in routine environments where a broad variety of food commodities must be analyzed simultaneously.

Method
Typically, analytes are extracted with a mixture of water, acidified methanol, and dichloromethane. Optionally, for dairy products and byproducts, extraction can be performed with water, acidified methanol, and EDTA, followed by two steps of cleanup (freezing out and dispersive solid-phase extraction with C18 in acetonitrile). Quantitative determination is carried out by isotopic dilution liquid chromatography tandem mass spectrometry (LC-MS/MS).

Results
The method was single-laboratory validated in five Nestlé Quality Assurance Centers (NQACs) in a comprehensive range of representative matrixes of different categories such as baby foods, infant/adult formulas, and ingredients, with results generally in agreement with the acceptance criteria of the Standard Method Performance Requirement (SMPR®) 2021.001 defined by AOAC INTERNATIONAL, in terms of representative matrixes validated, LOQs, trueness, and precision.
The data generated during validation show that the method proposed is simple, accurate and robust enough to be implemented and applied in routine environments.

Conclusion
The data generated during validation show that the method proposed is simple, accurate and robust enough to be implemented and applied in routine environments.

Highlights
The AOAC Expert Review Panel approved the present method as AOAC Official First Action 2022.06.
Trans-scale thermal signaling in biological systems
Authors: Suzuki Madoka , Liu Chujie , Oyama Kotaro , Yamazawa Toshiko 
Published: July 2023

Abstract
Biochemical reactions in cells serve as the endogenous source of heat, maintaining a constant body temperature. This process requires proper control; otherwise, serious consequences can arise due to the unwanted but unavoidable responses of biological systems to heat. This review aims to present a range of responses to heat in biological systems across various spatial scales. We begin by examining the impaired thermogenesis of malignant hyperthermia in model mice and skeletal muscle cells, demonstrating that the progression of this disease is caused by a positive feedback loop between thermally driven Ca2+ signaling and thermogenesis at the subcellular scale. After we explore thermally driven force generation in both muscle and non-muscle cells, we illustrate how in vitro assays using purified proteins can reveal the heat-responsive properties of proteins and protein assemblies. Building on these experimental findings, we propose the concept of ‘trans-scale thermal signaling’.
An advanced approach for rapid visual identification of Liposcelis bostrychophila (Psocoptera: Liposcelididae) based on CRISPR/Cas12a combined with RPA
Authors: Deng Wenxin , Feng Shiqian , Stejskal Vaclav , Opit George , Li Zhihong 
Published: July 2023

Abstract
Liposcelis bostrychophila Badonnel (Psocoptera: Liposcelididae) is a booklouse pest that is a threat to commodity storage security worldwide. Accurate and sensitive methods of L. bostrychophila on-site identification are essential prerequisites for its effective management. Evidence suggests that L. bostrychophila contains 3 intraspecific biotypes that are morphologically indistinguishable but can be discriminated at the level of mitochondrial genome organization and sequences. The traditional molecular identification methods, such as DNA barcoding and PCR-RFLP, are instrumentally demanding and time-consuming, limiting the application of the identification in the field. Therefore, this study developed a new CRISPR/Cas12a-based visual nucleic acid system based on the mitochondrial gene coding for NADH dehydrogenase subunit 2 (nad2), combined with recombinase polymerase amplification (RPA) to accurately identify L. bostrychophila from 4 other common stored-product booklice, and also differentiate 3 biotypes of this species at the same time. The entire identification process could be completed at 37 °C within 20 min with high sensitivity. The system could stably detect at least 1 ng/μl of DNA template. The green fluorescence signal produced by the trans-cleaving of the single-stranded DNA reporter could be observed by the naked eye under blue light. Additionally, the suggested system combined with the crude DNA extraction method to extract DNA rapidly, enabled identification of all developmental stages of L. bostrychophila. With crude DNA, this novel diagnostic system successfully identified an unknown booklouse by holding the reaction tubes in the hand, thus can be considered as an accurate, rapid, highly sensitive, and instrument-flexible method for on-site visual identification of L. bostrychophila.
Unique fluorophilic pores engineering within porous aromatic frameworks for trace perfluorooctanoic acid removal
Authors: Zhang Chi , Dong Junchao , Zhang Panpan , Sun Lei , Yang Liu , Wang Wenjian , Zou Xiaoqin , Chen Yunning , Shang Qingkun , Feng Danyang , Zhu Guangshan 
Published: July 2023

ABSTRACT
Perfluorooctanoic acid (PFOA), a representative of per/polyfluorinated alkyl substances, has become a persistent water pollutant of widespread concern due to its biological toxicity and refractory property. In this work, we design and synthesize two porous aromatic frameworks (PAF) of PAF-CF3 and PAF-C2F5 using fluorine-containing alkyl based monomers in tetrahedral geometry. Both PAFs exhibit nanosized pores (∼1.0 nm) of high surface areas (over 800 m2 g−1) and good fluorophilicity. Remarkable adsorption capacity (˃740 mg g−1) and superior efficiency (˃24 g mg−1 h−1) are achieved toward the removal of PFOA with 1 μg L−1 concentration owing to unique C–F···F–C interactions. In particular, PAF-CF3 and PAF-C2F5 are able to reduce the PFOA concentration in water to 37.9 ng L−1 and 43.3 ng L−1, below EPA regulations (70 ng L−1). The reusability and high efficiency give both PAFs a great potential for sewage treatment.
Nutritional interventions for exercise-induced muscle damage: an umbrella review of systematic reviews and meta-analyses of randomized trials
Authors: Talebi Sepide , Mohammadi Hamed , Zeraattalab-Motlagh Sheida , Arab Arman , Keshavarz Mohammadian Mohammad , Ghoreishy Seyed Mojtaba , Abbaspour Tehrani Fard Maryam , Amiri Khosroshahi Reza , Djafarian Kurosh 
Published: July 2023

Abstract

Context
Several meta-analyses have been conducted on the effect of nutritional interventions on various factors related to muscle damage. However, the strength of the evidence and its clinical significance are unclear.

Objectives
This umbrella review aimed to provide an evidence-based overview of nutritional interventions for exercise-induced muscle damage (EIMD).

Data sources
PubMed, Scopus, and ISI Web of Science were systematically searched up to May 2022.

Data Extraction
Systematic reviews and meta-analyses of randomized controlled trials investigating nutritional interventions' effects on recovery following EIMD were included. The certainty of the evidence was rated using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE).

Results
Fifty-three randomized controlled trial meta-analyses were included, evaluating 24 nutritional interventions on 10 different outcomes. The results revealed a significant effect of hydroxymethylbutyrate (HMB) supplementation and l-carnitine supplementation for reducing postexercise creatine kinase; HMB supplementation for reducing lactate dehydrogenase; branched-chain amino acids and leaf extract supplementation for reducing the delayed onset of muscle soreness; and l-carnitine, curcumin, ginseng, polyphenols, and anthocyanins for reducing muscle soreness, all with moderate certainty of evidence.

Conclusions
Supplementation with HMB, l-carnitine, branched-chain amino acids, curcumin, ginseng, leaf extract, polyphenols, and anthocyanins showed favorable effects on some EIMD-related outcomes.

Protocol Registration
PROSPERO registration no. CRD42022352565.