bluuebunny/crossref_metadata_2025_split huggingface dataset:
Detection of pyridine derivatives by SABRE hyperpolarization at zero field
Authors: Put Piotr , Alcicek Seyma , Bondar Oksana , Bodek Łukasz , Duckett Simon , Pustelny Szymon 
Published: June 2023

AbstractNuclear magnetic resonance (NMR) spectroscopy is a powerful analytical tool used in modern science and technology. Its novel incarnation, based on measurements of NMR signals without external magnetic fields, provides direct access to intramolecular interactions based on heteronuclear scalar J-coupling. The uniqueness of these interactions makes each zero-field NMR spectrum distinct and useful in chemical fingerprinting. However, the necessity of heteronuclear coupling often results in weak signals due to the low abundance of certain nuclei (e.g., 15N). Hyperpolarization of such compounds may solve the problem. In this work, we investigate molecules with natural isotopic abundance that are polarized using non-hydrogenative parahydrogen-induced polarization. We demonstrate that spectra of hyperpolarized naturally abundant pyridine derivatives can be observed and uniquely identified whether the same substituent is placed at a different position of the pyridine ring or different constituents are placed at the same position. To do so, we constructed an experimental system using a home-built nitrogen vapor condenser, which allows for consistent long-term measurements, crucial for identifying naturally abundant hyperpolarized molecules at a concentration level of ~1 mM. This opens avenues for future chemical detection of naturally abundant compounds using zero-field NMR.
High-plex immunofluorescence imaging and traditional histology of the same tissue section for discovering image-based biomarkers
Authors: Lin Jia-Ren , Chen Yu-An , Campton Daniel , Cooper Jeremy , Coy Shannon , Yapp Clarence , Tefft Juliann B. , McCarty Erin , Ligon Keith L. , Rodig Scott J. , Reese Steven , George Tad , Santagata Sandro , Sorger Peter K. 
Published: June 2023

AbstractPrecision medicine is critically dependent on better methods for diagnosing and staging disease and predicting drug response. Histopathology using hematoxylin and eosin (H&E)-stained tissue (not genomics) remains the primary diagnostic method in cancer. Recently developed highly multiplexed tissue imaging methods promise to enhance research studies and clinical practice with precise, spatially resolved single-cell data. Here, we describe the ‘Orion’ platform for collecting H&E and high-plex immunofluorescence images from the same cells in a whole-slide format suitable for diagnosis. Using a retrospective cohort of 74 colorectal cancer resections, we show that immunofluorescence and H&E images provide human experts and machine learning algorithms with complementary information that can be used to generate interpretable, multiplexed image-based models predictive of progression-free survival. Combining models of immune infiltration and tumor-intrinsic features achieves a 10- to 20-fold discrimination between rapid and slow (or no) progression, demonstrating the ability of multimodal tissue imaging to generate high-performance biomarkers.
Hearing Health Care Stakeholders' Perspectives on Teleaudiology Implementation: Lessons Learned During the COVID-19 Pandemic and Pathways Forward
Authors: Mui Boaz , Muzaffar Jameel , Chen Jinsong , Bidargaddi Niranjan , Shekhawat Giriraj Singh 
Published: June 2023

Purpose:
The purpose of this study was to explore how teleaudiology is perceived by Australian-based hearing health care stakeholders (clients, clinicians, students, academics, and industry partners) to inform future teleaudiology implementation.

Method:
Five cross-sectional online surveys were adopted, and a total of 366 stakeholders responded (173 clients, 110 clinicians, 58 students, 19 academics, and six industry partners).

Results:
Results show that 55% of clients and over 90% of clinicians, students, academics, and industry partners knew what teleaudiology was. Experience in teleaudiology appointments was shared by 85% of clinicians and 7% of clients. Moreover, 98% of clients were not offered any teleaudiology appointments. Teleaudiology apps were used by 66% of clinicians and 26% of clients. Both clients and clinicians acknowledged the benefits of teleaudiology including convenience and accessibility and identified drawbacks, such as loss of personal interaction and communication difficulty. About 80% of students and academics reported inclusion of teleaudiology within their universities' curriculum but only to a limited extent. Low teleaudiology uptake rates in placement clinics, as well as insufficient funding and staffing, were suggested as barriers to learning and teaching teleaudiology. Industry partners were generally confident in training clinicians to use teleaudiology products and teaching students on teleaudiology, but only one industry partner had been invited by universities for teaching purposes.

Conclusions:
Low teleaudiology use and reserved attitudes toward widespread teleaudiology implementation were observed among clients. Clinicians, students, academics, and industry partners generally displayed positive attitudes toward teleaudiology use. Increasing awareness of teleaudiology services and collaboration between stakeholders are crucial in promoting teleaudiology uptake.

Supplemental Material:

https://doi.org/10.23641/asha.23519292
Das biomechanische E-Staging: In-vivo-Biomechanik beim Keratokonus
Authors: Flockerzi Elias , Xanthopoulou Kassandra , Munteanu Cristian , Daas Loay , Langenbucher Achim , Seitz Berthold 
Published: June 2023

ZusammenfassungDie ABCD-Klassifikation des Keratokonus nach Belin ermöglicht eine Stadieneinteilung des Keratokonus basierend auf den Kriterien Vorder- (A) und Rückflächenverkrümmung (B), dünnster
Pachymetrie (C) und bestkorrigiertem Visus mit Brille (D). Diese Parameter ermöglichen auch eine Progressionsbeurteilung, berücksichtigen jedoch nicht die korneale Biomechanik. Die korneale
Biomechanik ermöglicht mit dem Corvis ST (Oculus, Wetzlar, Deutschland) zunächst die Trennung zwischen gesunden und Keratokonus-Hornhäuten mittels Corvis Biomechanischem Index (CBI) und
Tomografisch-Biomechanischem Index (TBI). Bei hoher Reliabilität der Corvis-ST-Messungen in unterschiedlichen Keratokonus-Stadien wurde daher ein biomechanischer Parameter für
Keratokonus-Hornhäute entwickelt, der eine biomechanische Stadieneinteilung des Keratokonus ermöglicht und der auf dem linearen Term des CBI basiert. Dieser Corvis Biomechanische Faktor
(CBiF) ist zugleich Grundlage der Einführung des biomechanischen E-Stagings, was die ABCD-Klassifikation um den Eckpfeiler der kornealen Biomechanik erweitert. Der Artikel zeigt Stärken und
Limitationen der ABCDE-Klassifikation auf. Der (vermeintlich) „einseitige Keratokonus“ erweist sich zumeist als Momentaufnahme einer stark asymmetrisch ausgeprägten Keratektasie. Der
reguläre Astigmatismus ist mitunter eine wichtige Differenzialdiagnose zur Keratektasie und schwierig von dieser abzugrenzen. Zudem wird die Anwendung des biomechanischen E-Stagings zur
Progressionsbeurteilung des Keratokonus und nach Behandlung mittels kornealem Crosslinking oder Implantation intrakornealer Ringsegmente demonstriert und diskutiert.
Selektives Trockenstellen auf bayerischen Betrieben – eine
Fallserie
Authors: Sorge Ulrike S. , Huber-Schlenstedt Reglindis , Schierling Katharina 
Published: June 2023

ZusammenfassungBei dieser Fallserie wurde die Umsetzung des selektiven Trockenstellens auf 90
bayerischen Milchviehbetrieben bezüglich der Reduktion von
antibiotischen Behandlungen zum Trockenstellen sowie deren Auswirkung auf die
Eutergesundheit untersucht. Zwischen 2016 und 2021 wurden die Betriebe teilweise
für mehr als 3 Jahre hierbei begleitet und jährlich
Viertelgemelksproben aller laktierenden Kühe der Herden genommen sowie
Behandlungs- und Probemelkergebnisse ausgewertet. In einigen Herden wurden zu
Beginn kontagiöse Erreger (Streptococcus agalactiae oder
Streptococcus canis) nachgewiesen und durchschnittlich waren
62% der Kühe zu Beginn antibiotisch zum Trockenstellen behandelt
worden. Die Häufigkeit von Trockensteherbehandlungen schwankte von Jahr
zu Jahr bei den Betrieben, zeigte aber im Durchschnitt eine sinkende Tendenz.
Die Eutergesundheit der Herden (Zellzahl) blieb über die Jahre
annähernd gleich, die kuhassoziierten Erreger wurden weniger. Lediglich
ab Jahr 3 stieg die Neuinfektionsrate während der Trockenstehphase.
Evaluation of multifactorial digestive disorders in a dairy herd at
different stages of lactation
Authors: Schären-Bannert Melanie , Wippermann Wolf , Wöckel Adriana , Vogel Laura , Waurich Benno , Rachidi Fanny , Fröhlich Franz , Felgentreu Christina , Wittich Julia , Bannert Erik , Hermenau Guntram , Hufe Peter , May Detlef , Dänicke Sven , Swalve Hermann , Starke Alexander 
Published: June 2023

AbstractThe manager of a large dairy herd (total confinement, total mixed ration feeding,
10130 kg milk sold per cow and year) requested a workup of a digestive
disorder problem that had been ongoing for several years. The cows were at all
stages of lactation, and the incidence proportion (events/100 cows at
risk) of digestive disorders was approximately 5 to 10%. The clinical
picture included an abnormal demeanor of varying severity and signs that
differed among the cows. The latter included decreased milk production and
physical activity, low body condition score, abnormal rumen motility and
stratification, small intestinal dilatation, diarrhea, undigested fiber
particles in the feces, fever and abdominal pain.The following approach was used to investigate the digestive disorder
problem:1. The herd was assessed for production levels, housing requirements, feeding
protocols and animal health management. The latter comprised evaluation of
different animal scores, metabolic profile analysis, diagnosis of disease,
culling records and slaughter data. The results revealed risk factors concerning
the feeding and animal health monitoring, (e. g. in dry matter intake
and silage quality management, disease detection and diagnosis in fresh cows).
The assessment also identified a high occurrence of digestive disorders of
unknown origin.2. Fifteen cows that represented the ongoing digestive disorder problem were
selected to undergo clinical examination, hematological analysis, urinalysis,
and ultrasonography of the ventral abdomen. The clinical examinations revealed
different digestive disorders, which were mainly inflammatory in nature, in all
the cows. Eight cows had localized reticuloperitonitis and 13 had left displaced
abomasum with different degrees of displacement and adhesions between the
abomasum and reticulum attributable to reticuloperitonitis.Our results revealed a multifactorial problem caused by several risk factors
relating to animal health and feeding management protocols that resulted in
different types of digestive disorders. The wires from damaged tires used to
hold the pit silo tarps in place were identified as a possible traumatic cause
of the reticuloperitonitis. Treatment, prevention and follow-up of the different
conditions were discussed.
Hop-derived Humulinones Reveal Protective Effects in in vitro Models of Hepatic Steatosis, Inflammation and Fibrosis
Authors: Mahli Abdo , Thasler Wolfgang E. , Biendl Martin , Hellerbrand Claus 
Published: June 2023

AbstractNonalcoholic fatty liver disease (NAFLD) is emerging as leading cause of liver disease worldwide. Specific pharmacologic therapy for NAFLD is a major unmet medical need. Recently, iso-alpha
acids, hop-derived bitter compounds in beer, have been shown to beneficially affect NAFLD pathology. Humulinones are further hop derived bitter acids particularly found in modern styles of
beer. So far, biological effects of humulinones have been unknown. Here, we investigated the effect of humulinones in in vitro models for hepatic steatosis, inflammation and fibrosis.
Humulinones dose-dependently inhibited fatty acid induced lipid accumulation in primary human hepatocytes. Humulinones reduced the expression of fatty acid uptake transporter CD36 and key
enzymes of (de novo) lipid synthesis. Conversely, humulinones increased the expression of FABP1, CPT1 and ACOX1, indicative for increased lipid combustion. Furthermore, humulinones
ameliorated steatosis induced pro-inflammatory gene expression. Furthermore, humulinones significantly reduced the expression of pro-inflammatory and pro-fibrogenic factors in control as
well as lipopolysaccharide treated activated hepatic stellate cells, which play a key role in hepatic fibrosis. In conclusion, humulinones beneficially affect different pathophysiological
steps of NAFLD. Our data suggest humulinones as promising therapeutic agents for the prevention and treatment of NAFLD.
An Efficient One-Pot, Three-Component Synthesis of Tetrasubstituted Pyrroles under Catalyst- and Solvent-Free Conditions
Authors: Maheswari C. Uma , Karthiyayini Gnanaoli , Rajkumar Deepan Babu , Nagarajan Subbiah , Sridharan Vellaisamy 
Published: June 2023

AbstractAn environmentally benign, catalyst- and solvent-free, three-component synthesis of tetrasubstituted pyrroles was established. The reaction proceeds via a nucleophilic attack of primary amine on dialkyl acetylenedicarboxylate followed by Michael addition with β-nitrostyrene and successive intramolecular cyclization and aromatization to yield 1,2,3,4-tetrasubstituted pyrroles in good to excellent yields. A wide range of primary amines including aromatic amines and benzylamines were coupled with differently substituted β-nitrostyrenes and dialkyl acetylenedicarboxylate. Furthermore, compared to previous reported methods, the present study is highly atom economical and environmentally benign and can be scaled up.
C–H Functionalization of Arenes via NHC-Supported Ni/Al Bimetallic Catalysis
Authors: Shi Shi-Liang , Jiang Binyang 
Published: June 2023

AbstractDespite the C–H functionalization of arenes offering an efficient synthetic route towards functionalized aromatic compounds with high atom- and step-economy, the low reactivity of the C–H bond makes this transformation rather challenging. Compared with mono-metal catalysis, the introduction of bimetallic catalysis would greatly enhance the reactivity and selectivity of this transformation. In this review, we highlight recent progress in the C–H functionalization of arenes via NHC-Ni/Al catalysis. The added aluminum as a co-catalyst would activate arene through Lewis acid-base interaction, and regioselectivity could be controlled through the synergism of NHC-Ni and Al. This strategy could be also applied in enantioselective C–H alkylation with well-designed chiral NHC ligands.1	Introduction2	C–H Addition to Alkynes via C–H Activation3	C–H Alkylation via Ni/Al Bimetallic Catalysis3.1	Racemic Hydroarylation with Alkenes3.2	Asymmetric Hydroarylation with Alkenes4	Conclusion and Outlook
Halogenative Annulation Reactions of Alkyne-Tethered N- and O-Containing Arenes: Methods for Accessing Aryl-Fused Halogenated N- and O-Heterocycles
Authors: Thongsornkleeb Charnsak , Tummatorn Jumreang , Ruchirawat Somsak 
Published: June 2023

AbstractHalogenative annulation of alkyne-tethered N- and O-containing arenes represents a general strategy for the construction of various halogenated N- and O-heterocycles. The methods employed are useful in producing valuable synthetic building blocks carrying C(sp2)–halide functional groups, which are useful synthetic handles, especially for cross-coupling reactions and a myriad of other transformations. When the alkyne is tethered to the heteroatom via an aromatic ring, the reaction gives rise to aryl-fused halogenated heterocycles. In this Short Review, various past and present halogenative annulation methods to construct aryl-fused halogenated N- and O-heterocycles are examined, with a focus on more recent technologies and the various roles of the participating halogenating agents. Additionally, future directions for this age-old, but still very useful, reaction are considered.1	Introduction2	Synthesis of Aryl-Fused Halogenated N-Heterocycles2.1	Aryl-Fused Halogenated 5-Membered N-Heterocycles2.2	Aryl-Fused Halogenated 6-Membered N-Heterocycles2.3	Aryl-Fused Halogenated 7-Membered N-Heterocycles3	Synthesis of Halogenated O-Heterocycles3.1	Aryl-Fused Halogenated 5-Membered O-Heterocycles3.2	Aryl-Fused Halogenated 6-Membered O-Heterocycles3.3	Aryl-Fused Halogenated 7-Membered O-Heterocycles4	Conclusion
Discursive strategies in the branding of Fortune Global 500 Chinese manufacturing companies
Authors: Li Dongmei , Chow Ung T’chiang 
Published: June 2023

AbstractCompany profiles are increasingly used to construct the corporate brand of Fortune Global 500 Chinese Manufacturing Companies (FG500CMCs). However, the communication of the corporate brand through the company profile is not sufficiently explored. This article explored the discursive strategies that were exploited to construct the desired brand identities of the FG500CMCs. Through the approach of critical genre analysis, it is found that the branding of the FG500CMCs is realized by the strategic organization of rhetorical moves, the purposeful employment of rhetorical devices, and tactical wording. All the obligatory moves identified primarily highlight a set of attributes indicating the strengths, competitiveness, and superiority of the FG500CMCs. This projects the distinctiveness of the brand identities of the companies. The strengths, competitiveness, and superiority are constructed by deploying graduation resources, appropriating numerical resources, adopting high-end and high-tech-related terms, and exploiting endorsement, authentication, and altruism. Besides analyzing the lexico-grammatical features and discursive techniques, this article also investigates how the FG500CMCs’ particular attributes and strengths are covertly conveyed through the strategic organization and distribution of the moves. This provides a more comprehensive explication and thus gives new insights into the body of knowledge on the discursive construction of corporate branding. With grounded elaboration on the tactful use of language and covert arrangement of the moves, this article also sheds light on the content design of the ‘company profile’ for shaping stakeholders’ and the public’s perception of the corporate brand.
Strain and voltage control of the magnetic anisotropy in Co2MnSi thin film
Authors: Peng Hua , Chen Gang 
Published: June 2023

Abstract
The strain effect on the magnetic anisotropy (MA) in free-standing Co2MnSi(001) thin film and the voltage control MA in Au-capped MgO/Co2MnSi thin film are investigated within the framework of density functional theory. We find that the MA of free-standing film with MnSi-termination is sensitive upon strain, while the magnetic easy axis changes from in-plane to out-of-plane under the applied in-plane 1% extension strain. The MA of Au-capped Co2MnSi/MgO shows a ∧-shaped electric-field dependence and a large voltage-controlled MA value (VCMA) of 225 fJ (Vm)−1. The VCMA is caused by the change of the spin-flip term, which is related to the energy shift of the Co dz
2 minority-spin band near the Fermi level. Based on this study, it is expected that Co2MnSi can potentially be used in magnetoelectric spintronic devices.
Antiferromagnetic order and its interplay with superconductivity in CaK(Fe1−x
Mn
x
)4As4
Authors: Wilde J M , Sapkota A , Ding Q-P , Xu M , Tian W , Bud’ko S L , Furukawa Y , Kreyssig A , Canfield P C 
Published: June 2023

Abstract
The magnetic order for several compositions of CaK(Fe

1
−
x

Mn
x
)4As4 has been studied by nuclear magnetic resonance (NMR), Mössbauer spectroscopy, and neutron diffraction. Our observations for the Mn-doped 1144 compound are consistent with the hedgehog spin vortex crystal (hSVC) order which has previously been found for Ni-doped

Ca
K

Fe
4

As
4

. The hSVC state is characterized by the stripe-type propagation vectors

(
π
0
)

and

(
0
π
)

just as in the doped 122 compounds. The hSVC state preserves tetragonal symmetry at the Fe site, and only this SVC motif with simple antiferromagnetic (AFM) stacking along
c
is consistent with all our observations using NMR Mössbauer spectroscopy, and neutron diffraction. We find that the hSVC state in the Mn-doped 1144 compound coexists with superconductivity, and by combining the neutron scattering and Mössbauer spectroscopy data we can infer a quantum phase transition, hidden under the superconducting dome, associated with the suppression of the AFM transition temperature (T
N) to zero for x ≈ 0.01. In addition, unlike several 122 compounds and Ni-doped 1144, the ordered magnetic moment is not observed to decrease at temperatures below the superconducting transition temperature (T
c).
Quaternary 2D monolayer Cu2Cl2Se2Hg2: anisotropic carrier mobility and tunable bandgap for transistor and photocatalytic applications
Authors: Xu Yuehua , Long Qianqian , Zeng Qiang , Li Daqing , Li Pengfei 
Published: June 2023

Abstract
Despite the advantages of quaternary two-dimensional (2D) materials, fewer studies have been done on them than binary 2D materials. Calculations of quaternary 2D monolayer Cu2Cl2Se2Hg2 based on density functional theory and Green’s function surface analysis provide insights into its structural, dynamic, and thermal stability. This material has a direct band gap of 0.91/2.0 eV (Perdew–Burke–Ernzerhof/Heyd–Scuseria–Ernzerhof) and demonstrates anisotropic carrier mobility. The electron mobility in the a direction is 1.2 × 103 cm2 V−1 s−1, which is significantly higher than the hole mobility of 0.48 × 103 cm2 V−1 s−1. In the b direction, the electron mobility is 1.01 × 103 cm2 V−1 s−1 and is 8.9 times larger than the hole mobility of 0.11 × 103cm2 V−1 s−1. The light absorption coefficients of Cu2Cl2Se2Hg2 are 1.0 × 105 cm−1 and 2.5 × 105 cm−1 in the visible and ultraviolet ranges, respectively. Uniaxial strain leads to an anisotropic alteration in the band gap and band edge position. By manipulating the strain direction and level in Cu2Cl2Se2Hg2, it is possible to increase the current ON/OFF ratio for field-effect transistors (FETs) and to facilitate photocatalytic water splitting through a redox reaction. The research reveals that Cu2Cl2Se2Hg2, a 2D monolayer in the quaternary form, has promising capabilities as an alternative for creating crystal-oriented FETs and photocatalytic water splitting systems.
Evidence of weak itinerant ferromagnetism and Griffiths like phase in MnFeGe
Authors: Dara Hanuma Kumar , Patra Debashish , Moharana Gyanti Prakash , Sarangi S N , Samal D 
Published: June 2023

Abstract
Realizing the itinerant type of magnetic exchange in Mn-based alloys is quite unusual because of the weak hybridization between Mn-moments and conduction electrons. However, in the current study, we found MnFeGe to exhibit weak itinerant type magnetic character possibly arising due to the hybridization between Mn, Fe atoms with Ge atoms. Here, we present a comprehensive structural and magnetic study on polycrystalline MnFeGe. Rietveld refinement of the XRD pattern confirms that Mn and Fe atoms randomly (atomic disorder) occupy the 2a and 2d sites in MnFeGe. From the magnetic measurements, Curie temperature and saturation moment values are found to be 162 K and 1.58

μ

B

/

f
.
u
.

at 2 K, respectively. The relative low values of Curie temperature, saturation magnetic moment, and a large value of Rhodes–Wohlfarth ratio (∼3.4) indicate the weak itinerant ferromagnetic character of the system. The Takahashi spin fluctuation theory analysis further supports the weak itinerant ferromagnetism in MnFeGe. Besides, we also observed Griffiths phase (GP) like behavior above the Curie temperature, which is attributed to the presence of atomic disorder in the system. The presence of GP is further confirmed by the zero spontaneous magnetization. Our findings demonstrate that MnFeGe is one of the very few Mn-based systems with weak itinerant magnetic behavior.