bluuebunny/crossref_metadata_2025_split huggingface dataset:
Outcomes Following Radiofrequency Renal Denervation According to Antihypertensive Medications: Subgroup Analysis of the Global SYMPLICITY Registry DEFINE
Authors: Mahfoud Felix , Mancia Giuseppe , Schmieder Roland E. , Ruilope Luis , Narkiewicz Krzysztof , Schlaich Markus , Williams Bryan , Ribichini Flavio , Weil Joachim , Almerri Khaled , Sharif Faisal , Lauder Lucas , Wanten Marianne , Fahy Martin , Böhm Michael 
Published: June 2023

BACKGROUND:
The Global SYMPLICITY Registry DEFINE (Denervation Findings in Real World) investigates radiofrequency renal denervation (RDN) in a broad range of patients with hypertension. We evaluated whether the number or type of antihypertensive medications were associated with increased long-term blood pressure (BP) reductions and cardiovascular outcomes following radiofrequency RDN.

METHODS:
Patients underwent radiofrequency RDN and were categorized by baseline number (0–3 and ≥4) and different combinations of medication classes. BP changes were compared between groups through 36 months. Individual and composite major adverse cardiovascular events were analyzed.

RESULTS:

Of 2746 evaluable patients, 18% were prescribed 0 to 3 and 82% prescribed ≥4 classes. At 36 months, office systolic BP significantly decreased (
P
<0.0001) by −19.0±28.3 and −16.2±28.6 mm Hg in the 0 to 3 and ≥4 class groups, respectively. Twenty-four–hour mean systolic BP significantly decreased (
P
<0.0001) by −10.7±19.7 and −8.9±20.5 mm Hg, respectively. BP reduction was similar between the medication subgroups. Antihypertensive medication classes decreased from 4.6±1.4 to 4.3±1.5 (
P
<0.0001). Most decreased (31%) or had no changes (47%) to the number of medications, while 22% increased. The number of baseline antihypertensive medication classes was inversely related to the change in prescribed classes at 36 months (
P
<0.001). Cardiovascular event rates were generally low. More patients in the ≥4 compared with 0 to 3 medication classes had myocardial infarction at 36 months (2.8% versus 0.3%;
P
=0.009).

CONCLUSIONS:
Radiofrequency RDN reduced BP safely through 36 months, independent of the number and type of baseline antihypertensive medication classes. More patients decreased than increased their number of medications. Radiofrequency RDN is a safe and effective adjunctive therapy regardless of antihypertensive medication regimen.

REGISTRATION:

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT01534299.
Emojis: Metonymy in Meaning and Use
Authors: Morras Javier , Barcelona Antonio 
Published: June 2023

Abstract
Emojis are changing the way we communicate in digital text interactions nowadays. They allow us to express kinesthetic cues that are always present in face-to-face communication. Such non-verbal cues may be understood as windows into the emotional/attitudinal states of human beings, and they are conventionalized on the basis of metonymy which, as a mental shortcut, automatically connects facial expressions to the feelings and emotions triggering those expressions. Using a new methodological approach in the form of an entry model for metonymic description, the article intends to provide some insights on how the semantics of emojis is deeply linked to metonymic patterns. The emotions analyzed are hilarity and anger. The paper also briefly addresses the meaning and use of emojis for things and non-affective relations.
An Introduction to Andalusi Hebrew Metrics
Authors: Martínez Delgado José 
Published: June 2023

Throughout the last two centuries, Hebrew metrics was studied by leading linguists and specialists in medieval Hebrew poetry. Nowadays, it has disappeared from the academic discussion such that it is sometimes even difficult to find scansions or the name of the meter in new editions of poems. This book aims to rectify this gap, helping readers to understand the metric structure of this poetry in order to facilitate the work of editing and cataloguing those samples still in manuscript form for future editors.
Delgado presents his view of Andalusi Hebrew metrics, as encountered in medieval manuals of Arabic and Hebrew metrics and scattered notes in the works of Andalusi Hebrew philologists. Whilst twentieth-century scholars spoke about the adaptation of Arabic metrics to Hebrew, he instead approaches these compositions by Andalusi Jews (10th-13th c.) as Arabic metrics written in Hebrew, thus emphasising how Hebrew poetry of the Andalusi Jews can help us to understand the general evolution of Arabic strophic poetry, and its experimental evolution, which is quite unlike classical and strophic Arabic poetry.
This method respects the Hebrew vowel system, and does not necessitate alteration of word morphology, leaving the guttural letters quiescent (unless required by metrical license); nor does it necessitate guesses about metres that are not in the classical catalogue. Although the author has not found each and every classical metre from Andalusi Hebrew poetry included in this manual, they are all catalogued, either in case someone finds them in future or because they help us to comprehend the metrical structures that are characteristic of strophic poetry. As such, this monograph will be of great interest to scholars of Hebrew metrics.
Advancing Tropical Cyclone Precipitation Forecast Verification Methods and Tools
Authors: Newman Kathryn M. , Brown Barbara , Gotway John Halley , Bernardet Ligia , Biswas Mrinal , Jensen Tara , Nance Louisa 
Published: June 2023

Abstract
Tropical cyclone (TC) forecast verification techniques have traditionally focused on track and intensity, as these are some of the most important characteristics of TCs and are often the principal verification concerns of operational forecast centers. However, there is a growing need to verify other aspects of TCs as process-based validation techniques may be increasingly necessary for further track and intensity forecast improvements as well as improving communication of the broad impacts of TCs including inland flooding from precipitation. Here we present a set of TC-focused verification methods available via the Model Evaluation Tools (MET) ranging from traditional approaches to the application of storm-centric coordinates and the use of feature-based verification of spatially defined TC objects. Storm-relative verification using observed and forecast tracks can be useful for identifying model biases in precipitation accumulation in relation to the storm center. Using a storm-centric cylindrical coordinate system based on the radius of maximum wind adds additional storm-relative capabilities to regrid precipitation fields onto cylindrical or polar coordinates. This powerful process-based model diagnostic and verification technique provides a framework for improved understanding of feedbacks between forecast tracks, intensity, and precipitation distributions. Finally, object-based verification including land masking capabilities provides even more nuanced verification options. Precipitation objects of interest, either the central core of TCs or extended areas of rainfall after landfall, can be identified, matched to observations, and quickly aggregated to build meaningful spatial and summary verification statistics.
Sclerotherapy for congenital vascular malformations with mixing foam of polidocanol and liquid of bleomycin
Authors: Yang Wei-Hong , Xiang Xian-Jun , Li Hai-Lei 
Published: June 2023

Objective To evaluate the efficacy of sclerotherapy for congenital vascular malformation (CVM) using a combination of polidocanol foam and bleomycin liquid. Methods A retrospective review of a prospectively collected data on patients who had sclerotherapy for CVM from May 2015 to July 2022 was performed. Results A total of 210 patients with a mean age of 24.8 ± 2.0 years were included. Venous malformation (VM) was the most common type of CVM, accounting for 81.9% (172/210) of all patients. At 6 months follow-up, the overall clinical effective rate was 93.3% (196/210), and 50% (105/210) of patients were clinically cured. The clinical effective rates in VM, lymphatic, and arteriovenous malformation group were 94.2%, 100%, and 100%. Conclusion Sclerotherapy using a combination of polidocanol foam and bleomycin liquid is an effective and safe treatment for venous and lymphatic malformations. It is a promising treatment option with satisfactory clinical outcome in arteriovenous malformations.
Advancing a Multisectoral Platform for Nutrition-Sensitive Agriculture in Nigeria: Reflections on Effectiveness and Lessons Learned
Authors: Ezekannagha Oluchi , Adeyemi Olutayo , Ajieroh Victor , Onabolu Adeyinka 
Published: June 2023

Background: Inadequate coordination mechanisms and capacity to coordinate are limiting factors for maximizing the ability of agriculture to improve nutrition in Sub-Saharan Africa. Effective coordination requires the availability of a platform for stakeholder convening, planning, operationalization of ideas, communication, and accountability. Nigeria’s Federal Ministry of Agriculture and Rural Development established one such platform to support the institutionalization of nutrition-sensitive agriculture. Platform members include several departments within the Ministry, other ministries, and development partners. While the platform achieved key milestones and fostered collaboration, some gaps remained. Objective: This study reports an assessment to understand the perspectives of members of the coordination platform and identify ways of increasing effectiveness. Methods: Desk reviews of relevant documents and 18 key informant interviews were conducted. Documents and interview notes were coded and analysed to identify recurring themes. Themes were appraised using a nutrition coordination framework. Results: Sufficiently understanding the nutrition role of representatives’ own organization/department and the purpose of the coordination platform and its activities was important for success. The profile and seniority of representing officers also mattered. While the leadership of the Ministry was committed to advancing nutrition through agriculture, the coordination platform could improve its functionality through consistent leadership, increased seniority of member representatives, and appropriate communication. Conclusions: Multisectoral coordination platforms are necessary but do not alone achieve nutrition coordination. Effective leadership and investments in time, strategic orientation, and training are critical to achieving a shared purpose, individual sector fulfilment of nutrition roles, and additional coordination success factors.
Comparison of clinical examination, doppler and fistulogram for arterio-venous fistula surveillance in detecting secondary failure
Authors: Prabhakaran Manoj , Mahapatra Himansu sekhar , Nath Ranjith kumar , Pursnani Lalit , Balakrishnan Muthukumar , Singh Anamika , Singh Amandeep , Patil Sanket , Gautam Abhisek 
Published: June 2023

Background: Arteriovenous Fistula (AVF) surveillance is required to detect early dysfunction (thrombosis, stenosis) and its timely correction prolongs access-patency. Clinical examination (CE) and doppler have been used as screening/surveillance of AVF, for early detection of AVF dysfunction. Since there was inadequate evidence for KDOQI to make recommendations on AVF surveillance and on secondary failure rate. We compared CE, doppler and fistulogram as surveillance modalities in detecting a secondary failure in matured AVF. Methodology: This prospective-observational, single-center study, was done between December 2019-April 2021. CKD stage 5 patients on dialysis/Not-on-dialysis with matured AVF were included at third month. CE, doppler (blood flow, vein diameter, depth), and fistulogram were done at third and sixth month. Secondary failure was assessed at sixth month classifying AVF to patent/functional and failed group. Diagnostic tests were performed by comparing three methods considering fistulogram as gold-standard. Residual urine output is also monitored to look for any contrast induced residual renal function loss. Results: Of total 407 created AVF, 98 (24%) had primary failure. Twenty-five (6%) had surgical complications including unsuccessful AVF and aneurysm/rupture, 156 lost follow-up at third month, 104 consented patients were enrolled, 16 lost to follow-up subsequently, and 88 patients’ data were analyzed at the end. At the sixth month, 76(86.4%) had patent AVF, 8 (9.1%) had secondary failure (Thrombosis-4, Central Venous Stenosis-4), and 4 (4.1%) patients expired. Considering fistulogram as a diagnostic standard, CE showed 87.5% sensitivity, and 93.4% specificity (cohen’s kappa value of 0.66). Doppler had sensitivity and specificity of 87% and 96% respectively (cohen’s kappa value of 0.75), Combination of clinical examination with doppler showed sensitivity and specificity of 100% and 89% respectively. Conclusion: Although the secondary AVF failure rate is less than the primary, CE is an important and valuable tool in the diagnosis and surveillance of AVF in detecting its dysfunction. Moreover, CE with doppler can be used as a surveillance protocol that can detect early AVF dysfunction at par with Fistulogram.
Patient preferences of patient selection criteria for upper extremity vascularized composite allotransplantation: A qualitative study
Authors: Vanterpool Karen B. , Gacki-Smith Jessica , Downey Max C. , Nordstrom Michelle , Luken Michelle , Riggleman Tiffany , Fichter Shannon , Altema Withney , Jensen Sally E. , Dumanian Gregory A. , Cooney Carisa M. , Levan Macey L. , Tintle Scott , Brandacher Gerald , Gordon Elisa J. 
Published: June 2023

Background: Upper extremity vascularized composite allotransplantation is a life-enhancing reconstructive treatment option that aims to improve recipients’ quality of life and maximize function. This study assessed upper extremity vascularized composite allotransplantation patient selection criteria perceptions among individuals with upper extremity limb loss. The perceptions of individuals with upper extremity limb loss on patient selection criteria may enable vascularized composite allotransplantation centers to improve criteria to avoid mismatched expectations about the posttransplant vascularized composite allotransplantation experience and outcomes. Realistic patient expectations may increase patient adherence, improve outcomes, and reduce vascularized composite allotransplantation graft loss. Methods: We conducted in-depth interviews with civilian and military service members with upper extremity limb loss and upper extremity vascularized composite allotransplantation candidates, participants, and recipients from three US institutions. Interviews assessed perceptions of patient selection criteria for suitability as a candidate for upper extremity vascularized composite allotransplantation. Thematic analysis was used to analyze qualitative data. Results: A total of 50 individuals participated (66% participation rate). Most participants were male (78%), White (72%), with a unilateral limb loss (84%), and a mean age of 45 years. Six themes emerged regarding upper extremity vascularized composite allotransplantation patient selection criteria, including support for candidates who: (1) are of younger age, (2) are in good physical health, (3) have mental stability, (4) are willing to “put in the work,” (5) have specific amputation characteristics, and (6) have sufficient social support. Patients had preferences about selecting candidates with unilateral versus bilateral limb loss. Conclusions: Our findings suggest that numerous factors, including medical, social, and psychological characteristics, inform patients’ perceptions of patient selection criteria for upper extremity vascularized composite allotransplantation. Patient perceptions of patient selection criteria should inform the development of validated screening measures that optimize patient outcomes.
Relationship between resilience and death anxiety of the older adults during the coronavirus disease 2019 (COVID-19) pandemic
Authors: Rayatpisheh Fatemeh , Torabizadeh Camellia , Najafi Kalyani Majid , Farsi Zahra 
Published: June 2023

Abstract
Background
The outbreak of coronavirus disease 2019 (COVID-19) caused an increase in the incidence of physical and psychological problems, particularly in the older adult. Considering the special physical and mental health conditions of the older adult, they were more exposed to psychological problems associated with the pandemic, such as death anxiety. Therefore, assessing the psychological status of this group is necessary in order to implement appropriate interventions. The present study aimed to investigate the relationship between resilience and death anxiety in the older adult during the COVID-19 pandemic.

Methods
This descriptive-analytical study was conducted on 283 older adult people over the age of 60 years. The older adult population was selected from 11 municipal districts of Shiraz, Iran, using the cluster sampling method. The resilience and death anxiety scales were used for data collection. Data analysis was performed in SPSS version 22, using Chi-square test, t-test, and Pearson’s correlation coefficient test. A P-value less than 0.05 was considered statistically significant.

Results
The mean and standard deviation of the older adult’s resilience and death anxiety scores were 64.16 ± 9.59 and 6.3 ± 2.95, respectively. There was a significant correlation between resilience and death anxiety scores (P < 0.01, r=-0.290). Also, sex (P = 0.00) and employment status (P = 0.00) were significantly associated with the older adult’s resilience. Besides, sex (P = 0.010) and employment status (P = 0.004) were significantly related to death anxiety.

Conclusions
Our findings showcase levels of resilience and death anxiety in older adults during the covid-19 pandemic and suggest that resilience and death anxiety are inversely linked. This has implications on policy planning for future major health events.
Prevalence and factors associated with sputum smear non-conversion after two months of tuberculosis treatment among smear-positive pulmonary tuberculosis patients in Rwanda: a cross-sectional study
Authors: Gatete Gaetan , Njunwa Kato J , Migambi Patrick , Ntaganira Joseph , Ndagijimana Albert 
Published: June 2023

Abstract
Background
Non-conversion of sputum smear prolongs the infectivity of pulmonary tuberculosis patients and has been associated with unfavorable tuberculosis (TB) treatment outcomes. Nevertheless, there is a limited evidence on predictors of sputum smear non-conversion among smear-positive PTB (SPPTB) patients in Rwanda. Therefore, this study aimed to determine the factors associated with sputum smear non-conversion after two months of treatment among SPPTB patients in Rwanda.

Methods
A cross-sectional study was conducted among SPPTB patients registered in the national electronic TB reporting system by all health facilities countrywide (Rwanda) from July 2019 to June 2021. Eligible patients who had completed the first two months of anti-TB treatment and with smear results at the end of the second month of treatment were included in the study. Bivariate and multivariate logistic regression analyses were done using STATA version 16 to determine the factors associated with sputum smear non-conversion. Adjusted odds ratio (OR), 95% confidence interval (CI), and p-value < 0.05 was considered statistically significant.

Results
This study included 7,211 patients. Of them, 632 (9%) patients had sputum smear non-conversion at the end of the second month of treatment. In multivariate logistic regression analysis, age groups of 20–39 years (AOR = 1.7, 95% CI: 1.0-2.8) and 40–59 years (AOR:2, 95% CI: 1.1–3.3), history of first-line TB treatment failure (AOR = 2, 95% CI: 1.1–3.6), follow-up by community health workers(CHWs) (AOR = 1.2, 95% CI: 1.0-1.5), BMI < 18.5 at TB treatment initiation (AOR = 1.5, 95% CI: 1.2–1.8), and living in Northern Province of Rwanda (AOR = 1.4, 95% CI: 1.0–2.0), were found to be significantly associated with sputum smear non-conversion after two months of treatment.

Conclusion
Sputum smear non-conversion among SPPTB patients remains low in Rwanda compared to countries of similar health care setting. Identified risk factors for sputum smear non-conversion among SPPTB patients in Rwanda were age (20–39 years, 40–59 years), history of first-line TB treatment failure, follow up by CHWs, BMI < 18.5 at TB treatment initiation and residence (Northern province).
Molecular and clinical characterization of PTRF in glioma via 1,022 samples
Authors: Sun Si , Yang Changlin , Wang Kuanyu , Huang Ruoyu , Zhang Ke-nan , Liu Yanwei , Cao Zhi , Zhao Zheng , Jiang Tao 
Published: June 2023

AbstractPolymerase I and transcript release factor (PTRF) plays a role in the regulation of gene expression and the release of RNA transcripts during transcription, which have been associated with various human diseases. However, the role of PTRF in glioma remains unclear. In this study, RNA sequencing (RNA-seq) data (n = 1022 cases) and ﻿whole-exome sequencing (WES) data (n = 286 cases) were used to characterize the PTRF expression features. ﻿Gene ontology (GO) functional enrichment analysis was used to assess the biological implication of changes in PTRF expression. As a result, the expression of PTRF was associated with ﻿malignant progression in gliomas. Meanwhile, somatic mutational profiles and copy number variations (CNV) revealed the glioma subtypes classified by PTRF expression showed distinct genomic alteration. Furthermore, GO functional enrichment analysis suggested that PTRF expression was associated with cell migration and angiogenesis, particularly during an immune response. Survival analysis confirmed that a high expression of PTRF is associated with a poor prognosis. In summary, PTRF may be a valuable factor for the diagnosis and treatment target of glioma.
Epidemiology and risk factors for thrombosis in children and newborns: systematic evaluation and meta-analysis
Authors: Song Shuang , Li Zhuowei , Zhao Guozhen , Li Xintong , Wang Runying , Li Bo , Liu Qingquan 
Published: June 2023

Abstract
Background
Thrombosis is a serious condition in children and neonates. However, the risk factors for thrombosis have not been conclusively determined. This study aimed to identify the risk factors for thrombosis in children and neonates in Intensive Care Unit (ICU) through a meta-analysis to better guide clinical treatment.

Methods
A systematic search of electronic databases (PubMed, Embase, Cochrane Library, WOS, CNKI, Wanfang, VIP) was conducted to retrieve studies from creation on 23 May 2022. Data on the year of publication, study design, country of origin, number of patients/controls, ethnicity, and type of thrombus were extracted. The publication bias and heterogeneity between studies were assessed, and pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using fixed or random effects models.

Results
A total of 18 studies met the inclusion criteria. The incidence of thrombosis in children was 2% per year (95% CI 1%-2%, P < 0.01). Infection and sepsis (OR = 1.95, P < 0.01), CVC (OR = 3.66, [95%CL 1.78–7.51], P < 0.01), mechanical ventilation (OR = 2.1, [95%CL1.47–3.01], P < 0.01), surgery (OR = 2.25, [95%CL1.2–4.22], P < 0.01), respiratory distress (OR = 1.39, [95%CL0.42–4.63], P < 0.01), ethnicities (OR = 0.88, [95%CL 0.79–0.98], P = 0.78), gestational age (OR = 1.5, [95%CL1.34–1.68], P = 0.65)were identified as risk factors for thrombosis.

Conclusions
This meta-analysis suggests that CVC, Surgery, mechanical ventilation, Infection/sepsis, gestational age, Respiratory distress, and different ethnicities are risk factors for thrombosis in children and neonates in ICU. These findings may help clinicians to identify high-risk patients and develop appropriate prevention strategies.

Trial registration
PROSPERO (CRD 42022333449).