bluuebunny/crossref_metadata_2025_split huggingface dataset:
Advances on Highly Selective and Non-Invasive Screening of Cancer Biomarkers using Surface Enhanced Raman Scattering with Nanoparticles
Authors: Madhivanan Keerthana , Sundramoorthy Ashok K. 
Published: January 2025

Abstract:
Cancer has long been the leading cause of death in many countries. This complex
category of diseases is characterized by the uncontrolled growth and spread of abnormal cells.
To reduce the cancer mortality rate, early detection of the disease is essential. As a result, extensive
research is directed towards the early identification of the cancer disease by developing
novel cancer cell detection technologies. One such novel technology is Surface Enhanced Raman
Scattering [SERS]. This technique is highly sensitive because of the highly enhanced
SERS signals due to metal nanoparticles, which allow the detection of ultra-low concentration
[femto-molar] of several important cancer biomarkers. Moreover, metal nanoparticle-based
SERS is found to be more sensitive and can be used for the detection of cancer cells or biomarkers
over a longer period. The SERS is also useful for multiple biomarker detection.
Compared to other fluorescence bands, Raman bands are narrower, which allows for the individual
and simultaneous detection of multiple biomarkers. In this context, we have outlined the
latest advancements in SERS for the effective detection of cancer biomarkers. Additionally,
we discuss the current challenges and future potential of SERS in cancer cell detection.
Investigation of the Anticarcinogenic Effects of Hypericum perforatum Extract on
Human Thyroid Cancer
Authors: Gokcek-Sarac Cigdem , Altunkaya Gizem , Karakurt Serdar 
Published: January 2025

Introduction/Objective:
Plants and their bioactive compounds play a crucial role in the pharmaceutical
industry for treating cancer. To date, the cytotoxic and antiproliferative effects of Hypericum perforatum methanol
extract on human thyroid cancer cell lines have not been thoroughly explored. The present study aimed to
assess the potential anti-cancer effects of HPME on human thyroid cancer and investigate its potential therapeutic
benefits.

Methods:
HPME was prepared using the maceration method, and its antioxidant activity was examined. Cytotoxicity
studies were then carried out, followed by an investigation of the possible effects of HPME on metastasis
and colony-forming capacities of human thyroid cancer cells. Afterward, qRT-PCR, western blotting, and apoptosis
assays were performed.

Results:
Cytotoxicity studies revealed notable cytotoxicity of HPME against the TT cell line. Moreover, HPME
significantly curtailed metastasis and invasion of TT cells in an in vitro wound healing assay. Analyses of gene
expressions demonstrated an elevation in caspase-12, caspase-3, and Bax, coupled with a reduction in BcL-2,
APOE, and CLU expression. Following HPME treatment, there was an increase in the protein expression levels
of Bax and Caspase-12, while a decrease in the BcL-2, APOE, and CLU protein expression. Furthermore, apoptotic
studies indicated an increase in early apoptosis.

Conclusion:
Overall results revealed that HPME demonstrates a notable antioxidant capacity in human thyroid
cancer. It exerts an influence on crucial biological processes associated with cancer, indicating its potential to
hinder the proliferation of human thyroid cancer cells by enhancing apoptosis through the upregulation of gene
and protein expression, particularly involving caspases.
Effect of COVID-19 and Related Lockdown on Young People’s Worries and Emotions in the Israeli Context
Authors: Shukla Meenakshi , Lavi Iris , Lau Jennifer Y.F. 
Published: January 2025

Introduction/Objective:
The outbreak of COVID-19 has undoubtedly
impacted all sections of the population across countries and continents. Here, we
describe the additional challenges that Israeli adolescents had to face due to the
pandemic and the ensuing lockdown, besides the difficulties posed by sociopolitical
turmoil in Israel. In particular, the current cross-sectional study aimed to
explore experiences of the COVID-19 pandemic and the resulting lockdown
among Israeli adolescents.

Methods:
A sample of 306 Israeli adolescents (mean age 15.32 ± 1.81 years) was
assessed on the level of social restrictions experienced, daily routines, and
emotional climate (i.e., worries, negative affect, and anhedonia).

Results:
Our results showed that while most participants (95.04%; 51.04% males)
did not personally experience the infection, they reported worrying about their
studies (43.14%) and about the health of relatives and friends (34.97%). Females
reported being more isolated (t(292) =-2.77, p= .01), having higher negative
affect (t(292) = -4.198, p= .02), and reported greater impact of the pandemic on
their study (t(292) =-2.44, p= .02), finance (t(292) =-3.10, p= .002), and emotions
(t(292) =-2.44, p= .02) than males. Both genders did not differ in their levels of
anhedonia, which was low (t(292) = 1.27, p= .20).

Conclusion:
Results underscore the impact of the pandemic on the academic and
social lives of youth and the content of their worries. In the special context of
Israel, a country that has undergone significant nationwide challenges, these
results indicate the resilience of young people alongside elevated levels of worry
and negative emotions.
Effectiveness of Remote Patient Monitoring Equipped With an Early Warning System in Tertiary Care Hospital Wards: Retrospective Cohort Study
Authors: Lakshman Pavithra , Gopal Priyanka T , Khurdi Sheen 
Published: January 2025

Background
Monitoring vital signs in hospitalized patients is crucial for evaluating their clinical condition. While early warning scores like the modified early warning score (MEWS) are typically calculated 3 to 4 times daily through spot checks, they might not promptly identify early deterioration. Leveraging technologies that provide continuous monitoring of vital signs, combined with an early warning system, has the potential to identify clinical deterioration sooner. This approach empowers health care providers to intervene promptly and effectively.

Objective
This study aimed to assess the impact of a Remote Patient Monitoring System (RPMS) with an automated early warning system (R-EWS) on patient safety in noncritical care at a tertiary hospital. R-EWS performance was compared with a simulated Modified Early Warning System (S-MEWS) and a simulated threshold-based alert system (S-Threshold).

Methods
Patient outcomes, including intensive care unit (ICU) transfers due to deterioration and discharges for nondeteriorating cases, were analyzed in Ramaiah Memorial Hospital’s general wards with RPMS. Sensitivity, specificity, chi-square test for alert frequency distribution equality, and the average time from the first alert to ICU transfer in the last 24 hours was determined. Alert and patient distribution by tiers and vitals in R-EWS groups were examined.

Results
Analyzing 905 patients, including 38 with deteriorations, R-EWS, S-Threshold, and S-MEWS generated more alerts for deteriorating cases. R-EWS showed high sensitivity (97.37%) and low specificity (23.41%), S-Threshold had perfect sensitivity (100%) but low specificity (0.46%), and S-MEWS demonstrated moderate sensitivity (47.37%) and high specificity (81.31%). The average time from initial alert to clinical deterioration was at least 18 hours for RPMS and S-Threshold in deteriorating participants. R-EWS had increased alert frequency and a higher proportion of critical alerts for deteriorating cases.

Conclusions
This study underscores R-EWS role in early deterioration detection, emphasizing timely interventions for improved patient outcomes. Continuous monitoring enhances patient safety and optimizes care quality.
Exploring Dance as a Therapeutic Approach for Parkinson Disease Through the Social Robotics for Active and Healthy Ageing (SI-Robotics): Results From a Technical Feasibility Study
Authors: Bevilacqua Roberta , Maranesi Elvira , Benadduci Marco , Cortellessa Gabriella , Umbrico Alessandro , Fracasso Francesca , Melone Giovanni , Margaritini Arianna , La Forgia Angela , Di Bitonto Pierpaolo , Potenza Ada , Fiorini Laura , La Viola Carlo , Cavallo Filippo , Leone Alessandro , Caroppo Andrea , Rescio Gabriele , Marzorati Mauro , Cesta Amedeo , Pelliccioni Giuseppe , Riccardi Giovanni Renato , Rossi Lorena 
Published: January 2025

Abstract

Background
Parkinson disease (PD) is a progressive neurodegenerative disorder characterized by motor symptoms. Recently, dance has started to be considered an effective intervention for people with PD. Several findings in the literature emphasize the necessity for deeper exploration into the synergistic impacts of dance therapy and exergaming for PD management. Moreover, socially engaging robotic platforms equipped with advanced interaction and perception features offer potential for monitoring patients’ posture and enhancing workout routines with tailored cues.

Objective
This paper presents the results of the Social Robotics for Active and Healthy Ageing (SI-Robotics) project, aimed at designing an innovative rehabilitation program targeted at seniors affected by (early-stage) PD. This study therefore aims to assess the usefulness of a dance-based rehabilitation program enriched by artificial intelligence–based exergames and contextual robotic assistance in improving motor function, balance, gait, and quality of life in patients with PD. The acceptability of the system is also investigated.

Methods
The study is designed as a technical feasibility pilot to test the SI-Robotics system. For this study, 20 patients with PD were recruited. A total of 16 Irish dance–based rehabilitation sessions of 50 minutes were conducted (2 sessions per week, for 8 wks), involving 2 patients at a time. The designed rehabilitation session involves three main actors: (1) a therapist, (2) a patient, and (3) a socially interacting robot. To stimulate engagement, sessions were organized in the shape of exergames where an avatar shows patients the movements they should perform to correctly carry out a dance-based rehabilitation exercise.

Results
Statistical analysis reveals a significant difference on the Performance-Oriented Mobility Assessment scale, both on balance and gait aspects, together with improvements in Short Physical Performance Battery, Unified Parkinson Disease Rating Scale–III, and Timed Up and Go test, underlying the usefulness of the rehabilitation intervention on the motor symptoms of PD. The analysis of the Unified Theory of Acceptance and Use of Technology subscales provided valuable insights into users’ perceptions and interactions with the system.

Conclusions
This research underscores the promise of merging dance therapy with interactive exergaming on a robotic platform as an innovative strategy to enhance motor function, balance, gait, and overall quality of life for patients grappling with PD.
eHealth Literacy and Cyberchondria Severity Among Undergraduate Students: Mixed Methods Study
Authors: Hsu Wan
-Chen 
Published: January 2025

Abstract

Background
With the development of the internet, health care websites have become increasingly important by enabling easy access to health information, thereby influencing the attitudes and behaviors of individuals toward health issues. However, few studies have addressed public access to health information and self-diagnosis.

Objective
This study investigated the background factors and status of cyberchondria severity among college students by conducting a nationwide sample survey using the Cyberchondria Severity Scale. Further, we explored the perspective of eHealth literacy of those with scores higher than 1 SD from the mean by analyzing their recent experiences using web-based health information.

Methods
A nationally representative sample of college students was surveyed, and 802 valid responses were obtained (male: 435/802, 54.2%; female: 367/802, 45.8%; mean age 20.3, SD 1.4 years). The Cyberchondria Severity Scale was used, which consisted of 4 dimensions (increased anxiety, obsessive-compulsive hypochondria, perceived controllability, and web-based physician-patient interaction). Additionally, we recruited 9 volunteers who scored more than 1 SD above the mean for in-depth interviews on their web-based health information–seeking behaviors.

Results
Significant differences were found across the 4 dimensions of cyberchondria severity (F3,2403=256.26; P<.001), with perceived controllability scoring the highest (mean 2.75, SD 0.87) and obsessive-compulsive hypochondria scoring the lowest (mean 2.19, SD 0.77). Positive correlations were observed between perceived controllability, web-based physician-patient interactions, increased anxiety, and obsessive-compulsive hypochondria (r=0.46-0.75, P<.001). Regression analysis indicated that health concern significantly predicted perceived controllability (β coefficient=0.12; P<.05) and web-based physician-patient interaction (β coefficient=0.16; P<.001). Interview data revealed that students often experienced heightened anxiety (8/9, 89%) and stress (7/9, 78%) after exposure to web-based health information, highlighting the need for improved health literacy and reliable information sources.

Conclusions
The study identified both benefits and risks in college students’ use of web-based health information, emphasizing the importance of critical consciousness and eHealth literacy. Future research should examine how college students move from self-awareness to actionable change and the development of critical health literacy, which are essential for effective digital health engagement.
Evaluating Online and Offline Health Information With the Patient Education Materials Assessment Tool: Protocol for a Systematic Review
Authors: Furukawa Emi , Okuhara Tsuyoshi , Liu Mingxin , Okada Hiroko , Kiuchi Takahiro 
Published: January 2025

Background
The Patient Education Materials Assessment Tool (PEMAT) is a reliable and validated instrument for assessing the understandability and actionability of patient education materials. It has been applied across diverse cultural and linguistic contexts, enabling cross-field and cross-national material quality comparisons. Accumulated evidence from studies using the PEMAT over the past decade underscores its potential impact on patient and public action.

Objective
This systematic review aims to investigate how the quality of patient education materials has been assessed using the PEMAT.

Methods
This review protocol follows PRISMA-P (Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols) guidelines. PubMed, MEDLINE, Cumulative Index to Nursing and Allied Health Literature (CINAHL), APA PsycInfo, and Web of Science Core Collection will be searched systematically for articles published since September 2014. Two independent reviewers will conduct the search to yield a list of relevant studies based on the inclusion and exclusion criteria. Rayyan QCRI software will be used for screening and data extraction.

Results
The results will be included in the full systematic review, which is expected to start in September 2024 and be completed to be submitted for publication by early 2025.

Conclusions
The findings are expected to identify the quality of materials evaluated by the PEMAT and the areas under evaluation. This review can also highlight gaps that exist in research and practice for improving the understandability and actionability of the materials, offering deeper insights into how existing materials can facilitate patient and public action.

International Registered Report Identifier (IRRID)
PRR1-10.2196/63489
Criticism of legal protection for victims of drug abuse: the disharmony in legal substance regulation
Authors: Laksana Andri Winjaya , Widodo Hendro , Siswanto Moh Aris , Djunaedi H. D. , Widiyoko Setiawan 
Published: January 2025

This research aims to analyse the legal regulation of narcotics addicts in Indonesia and legal protection for victims of drug abuse, the disharmony in legal substance regulation. Law Number 35 of 2009 concerning Narcotics in Indonesia establishes the legal framework for rehabilitation, protection and eradication of narcotics abuse at the national level. This regulation requires rehabilitation measures for narcotics users, especially those categorised as victims, and provides uniform law enforcement guidelines. On the other hand, regional regulations can expand and strengthen national regulations by adapting local approaches to suit the needs of local communities. This is legal research using qualitative research methods. Legal regulations for narcotics addicts in Indonesia are regulated in Law No. 35 of 2009 concerning Narcotics with a rehabilitative approach, but it still faces various challenges in its implementation. In Law No. 35 of 2009 concerning Narcotics, the disharmony of articles can arise due to several factors, including differing interpretations, unclear legal norms, or inconsistency with other relevant regulations. What is often debated is the different approaches between rehabilitation for narcotics addicts and criminal punishment for narcotics crime perpetrators in the Narcotics Law. Article 54 states that narcotics addicts are required to undergo medical and social rehabilitation. On the contrary, Article 127 paragraph (1) asserts that narcotics users without rights or against the law are subject to imprisonment.
Inheritance Rights of Nasabiyyah Children Born Out of Wedlock According to Islamic Family Law
Authors: Maulana Anas , Akbar Zainuri , Habibie Ramadhani Alfin , Norhadi Muhammad , Hasuna Kamal 
Published: January 2025

The inheritance rights of nasabiyyah children outside of marriage, religion or the state will not get inheritance because the status of the child follows his mother, not his father. The serious problem is how to maintain the rights that should be obtained by children born out of wedlock, and whether the development of science and technology is ignored, even though in the rules of a change in a law is dependent on the time, place, and context of the problem. This study uses a comprehensive juridical law method that is comparatively analyzed to present data and facts from the perspective of positive law and Islamic law as well as the role of technology and science. The data is sourced from articles, books, legal rules and other juridical sources. This study concludes that in positive law, especially civil law of inheritance, the status of the child's inheritance rights outside of marriage can be recognized as long as the biological father recognizes the child's destiny as his destiny. As for Islamic civil law, there is no legal leniency for children outside of marriage, if the child is born without a clear status from both parents, then the child follows his mother and not his father. Islam has flexible laws that can adapt to the existing context. From the point of view of Islamic law, there are several ways to determine nasab, one of which is the qiyafah technique. The technique can be qiyas-kan with the reading of the nasab through a DNA test because it has almost the same legal 'illat. With the advancement of technology and the development of science, the method of determining the nasab can also be developed.
The Importance of Applied Behavior Analysis (ABA) Therapy in Nurturing Children with Autism Spectrum Disorder (ASD) According to Maqāṣid al-Sharī’ah
Authors: Zainal Abidin Raihana , Alias Muhammad Nazir , Wakhidah Nur 
Published: January 2025

This study evaluates applied behavior analysis (ABA) therapy for individuals with autism spectrum disorder (ASD) from the perspective of maqasid syariah, addressing the lack of research in this area. The research questions focus on how ABA therapy aligns with the principles of Maqāṣid al-Sharī’ah in ASD treatment. This qualitative study collected data from journal articles, reference books, and authoritative internet sources, which were thematically analyzed using an inductive approach. The findings indicate that ABA therapy plays a crucial role in helping individuals with ASD achieve the objectives of Maqāṣid al-Sharī’ah, including the preservation of religion, life, intellect, lineage/dignity, and property. ABA therapy was found to be effective in enhancing the ability of individuals with ASD to understand and practice religious teachings, reducing harmful behaviors, obtaining proper nutrition, improving cognitive function and mental health, addressing problematic sexual behaviors, and increasing work capacity and independence.
Peran Rumah Sakit Dalam Pengurangan Risiko Bencana Erupsi Gunung Merapi Di Kabupaten Boyolali Indonesia
Authors: Isa Muzakar , Sutrisna EM , Purwani  
Published: January 2025

Penelitian ini bertujuan untuk identifikasi dan analisis peran rumah sakit dan stakeholders lainnya dalam pengurangan risiko bencana erupsi gunung merapi di Kabupaten Boyolali, Indonesia. Penelitian ini menggunakan pendekatan kualitatif dalam menganalisis 16 stakeholders yang terlibat dalam pengurangan risiko erupsi gunung merapi. Penelitian ini menggunakan data primer yang diperoleh secara langsung dari para stakeholders. Pengumpulan data menggunakan indepth interview untuk memperoleh data tentang jenis dan peran stakeholders pada pelaksanaan manajemen bencana. Analisis data menggunakan pendekatan analisis stakeholders dengan bantuan program MACTOR. Hasil analisis menjelaskan pengurangan risiko erupsi gunung merapi di Kabupaten Boyolali melibatkan 16 stakehorder yang saling berinteraksi dalam mengurangi risiko erupsi gunung merapi. Masing masing stakeholder memiliki kepentingan dan pengaruh yang beda beda pada keterlibatannya dalam manajemen bencana. Keterlibatan stakeholder dikelompokkan dalam 7 kepentingan atau tujuan, yaitu menjalankan tupoksi, memperoleh uang atau pendapatan, mencari jaringan dan teman, mengurangi korban fisik dan mental, mencari hiburan, dan misi sosial. Tupoksi merupakan kepentingan yang paling banyak dan paling tinggi, diiikuti oleh misi social dan mengurangi korban fisik dan mental. Forum Pengurangan risiko Bencana (FPRB), Badan Penanggulangan Bencana (BPBD), Komunitas Relawan dan RS Swasta memiliki peranan yang sangat besar dalam meningkatkan pengurangan risiko erupsi gunung merapi Di Kabupaten Boyolali. Keempat stakeholder ini menunjukkan konvergensi yang sangat kuat dalam meningkatkan mengurangi risiko bencana. Kedekatan kepentingan dan tujuan dalam mengurangi risiko menjadi modal penting terjadinya konvergensi yang kuat, yaitu misi sosial, menjalankan tupoksi dan mengurangi risiko korban. Hal ini memudahkan aliran informasi dan keberlanjutan mitigasi risiko bencana di Kabupaten Boyolali.