bluuebunny/crossref_metadata_2025_split huggingface dataset:
Additive Remanufacturing Integrated Design Approach for Performance Improvement of Automotive Components
Authors: Dalpadulo Enrico , Pini Fabio , Leali Francesco 
Published: February 2023

Abstract
Metal Additive Manufacturing technologies provide many advantages among industrial sectors. Most applications exploit design freedom for functional design enabled by Powder Bed Fusion processes, while Directed Energy Deposition systems are mainly restricted to the construction of large parts and reparation of damaged components. Nevertheless, the latter provide not only high deposition rates, but also high flexibility, and the possibility to process multi-materials, to grade and combine their characteristics for enhanced features and performance. Therefore, a rising application is the remanufacturing of existing components to produce functional design variants. Those parts can integrate different features and materials through direct deposition of metals over bounded areas. This work concerns the development of a Design for Additive Remanufacturing methodology for existing components with improved performances to be produced by the laser-based Direct Metal Deposition process. It relies on the use of CAD platforms for the integrated design of products and the associated processes. The design approach is based on the integration of CAE structural analysis and Topology Optimization, to define the location and the morphology of deposited structures. The design of an automotive suspension arm with enhanced performances is the use case to demonstrate the effectiveness of the approach, which could be extended to the remanufacturing of several bodies and chassis automotive subsystems.
Peer-provided psychological intervention for Syrian refugees: results of a randomised controlled trial on the effectiveness of Problem Management Plus
Authors: de Graaff Anne M , Cuijpers Pim , Twisk Jos W R , Kieft Barbara , Hunaidy Sam , Elsawy Mariam , Gorgis Noer , Bouman Theo K , Lommen Miriam J J , Acarturk Ceren , Bryant Richard , Burchert Sebastian , Dawson Katie S , Fuhr Daniela C , Hansen Pernille , Jordans Mark , Knaevelsrud Christine , McDaid David , Morina Naser , Moergeli Hanspeter , Park A-La , Roberts Bayard , Ventevogel Peter , Wiedemann Nana , Woodward Aniek , Sijbrandij Marit 
Published: February 2023

BackgroundThe mental health burden among refugees in high-income countries (HICs) is high, whereas access to mental healthcare can be limited.ObjectiveTo examine the effectiveness of a peer-provided psychological intervention (Problem Management Plus; PM+) in reducing symptoms of common mental disorders (CMDs) among Syrian refugees in the Netherlands.MethodsWe conducted a single-blind, randomised controlled trial among adult Syrian refugees recruited in March 2019–December 2021 (No. NTR7552). Individuals with psychological distress (Kessler Psychological Distress Scale (K10) >15) and functional impairment (WHO Disability Assessment Schedule (WHODAS 2.0) >16) were allocated to PM+ in addition to care as usual (PM+/CAU) or CAU only. Participants were reassessed at 1-week and 3-month follow-up. Primary outcome was depression/anxiety combined (Hopkins Symptom Checklist; HSCL-25) at 3-month follow-up. Secondary outcomes included depression (HSCL-25), anxiety (HSCL-25), post-traumatic stress disorder (PTSD) symptoms (PTSD Checklist for Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition; PCL-5), impairment (WHODAS 2.0) and self-identified problems (PSYCHLOPS; Psychological Outcomes Profiles). Primary analysis was intention-to-treat.FindingsParticipants (n=206; mean age=37 years, 62% men) were randomised into PM+/CAU (n=103) or CAU (n=103). At 3-month follow-up, PM+/CAU had greater reductions on depression/anxiety relative to CAU (mean difference −0.25; 95% CI −0.385 to −0.122; p=0.0001, Cohen’sd=0.41). PM+/CAU also showed greater reductions on depression (p=0.0002, Cohen’sd=0.42), anxiety (p=0.001, Cohen’sd=0.27), PTSD symptoms (p=0.0005, Cohen’sd=0.39) and self-identified problems (p=0.03, Cohen’sd=0.26), but not on impairment (p=0.084, Cohen’sd=0.21).ConclusionsPM+ effectively reduces symptoms of CMDs among Syrian refugees. A strength was high retention at follow-up. Generalisability is limited by predominantly including refugees with a resident permit.Clinical implicationsPeer-provided psychological interventions should be considered for scale-up in HICs.
Developing architecture of system management in the English NHS: evidence from a qualitative study of three Integrated Care Systems
Authors: Sanderson Marie , Allen Pauline , Osipovic Dorota , Petsoulas Christina , Boiko Olga , Lorne Colin 
Published: February 2023

ObjectiveIntegrated Care Systems (ICSs) mark a change in the English National Health Service to more collaborative interorganisational working. We explored how effective the ICS form of collaboration is in achieving its goals by investigating how ICSs were developing, how system partners were balancing organisational and system responsibilities, how partners could be held to account and how local priorities were being reconciled with ICS priorities.DesignWe carried out detailed case studies in three ICSs, each consisting of a system and its partners, using interviews, documentary analysis and meeting observations.Setting/participantsWe conducted 64 in-depth, semistructured interviews with director-level representatives of ICS partners and observed eight meetings (three in case study 1, three in case study 2 and two in case study 3).ResultsCollaborative working was welcomed by system members. The agreement of local governance arrangements was ongoing and challenging. System members found it difficult to balance system and individual responsibilities, with concerns that system priorities could run counter to organisational interests. Conflicts of interest were seen as inherent, but the benefits of collaborative decision-making were perceived to outweigh risks. There were multiple examples of work being carried out across systems and ‘places’ to share resources, change resource allocation and improve partnership working. Some interviewees reported reticence addressing difficult issues collaboratively, and that organisations’ statutory accountabilities were allowing a ‘retreat’ from the confrontation of difficult issues facing systems, such as agreeing action to achieve financial sustainability.ConclusionsThere remain significant challenges regarding agreeing governance, accountability and decision-making arrangements which are particularly important due to the recent Health and Care Act 2022 which gave ICSs allocative functions for the majority of health resources for local populations. An arbiter who is independent of the ICS may be required to resolve disputes, along with increased support for shaping governance arrangements.
Safety profile of upadacitinib over 15 000 patient-years across rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis and atopic dermatitis
Authors: Burmester Gerd R , Cohen Stanley B , Winthrop Kevin L , Nash Peter , Irvine Alan D , Deodhar Atul , Mysler Eduardo , Tanaka Yoshiya , Liu John , Lacerda Ana P , Palac Hannah , Shaw Tim , Mease Philip J , Guttman‑Yassky Emma 
Published: February 2023

ObjectiveTo evaluate the long-term safety profile for upadacitinib across rheumatoid arthritis (RA), psoriatic arthritis (PsA), ankylosing spondylitis (AS) and atopic dermatitis (AD).MethodsSafety data from clinical trials of upadacitinib 15 mg and upadacitinib 30 mg (AD only) for treating RA, PsA, AS and AD as of 30 June 2021 were analysed; some RA and PsA studies included adalimumab and methotrexate as active comparators. Treatment-emergent adverse events (TEAEs) were presented by disease as exposure-adjusted event rates per 100 patient years (E/100 PY).ResultsThe analysis included 6991 patients (RA, n=3209; PsA, n=907; AS, n=182; AD, n=2693) who received at least one dose of upadacitinib, representing 15 425 PY of exposure (maximum duration 2.75–5.45 years) across diseases. Rates (E/100 PY) of any TEAE (205.5–278.1) and TEAE leading to discontinuation (4.5–5.4) were similar across diseases; serious TEAEs were numerically higher in patients with RA and PsA. Rates of herpes zoster (1.6–3.6), non-melanoma skin cancer (0–0.8) and elevations in creatine phosphokinase levels (4.4–7.9) were higher with upadacitinib than with active comparators in the RA and PsA populations. Deaths (0–0.8), serious infections (0–3.9), major adverse cardiovascular events (0–0.4), venous thromboembolism (<0.1–0.4) and malignancies (0.3–1.4) were observed, with rates generally lowest in AS and AD. Increased rates of acne were observed in patients with AD only.ConclusionsFindings from this analysis demonstrate that upadacitinib is generally well tolerated with observed differences in safety profiles likely reflective of varying patient characteristics across RA, PsA, AS and AD populations.Trial registration numbersNCT02675426,NCT02706951,NCT02706847,NCT02629159,NCT02706873,NCT03086343,NCT03104374,NCT03104400,NCT03178487,NCT03569293,NCT03568318andNCT03607422.
The effect of piercing and drilling processes on burr formation and delamination of aged carbon and aramid fiber-reinforced polymer composites
Authors: Engin Kaan Emre , Kaya Ali Ihsan , Tandogan Mahmut 
Published: February 2023

There are two major problems with fiber-reinforced polymer (FRP) composites during their machining that need to be addressed. The first concern is the delamination and formation of burrs at machined edges, and the second is the effects of aging leading to mechanical deterioration. In this study, carbon FRP (CFRP) and aramid FRP (AFRP) composites were manufactured by vacuum infusion method and aged for 2 years under natural environmental conditions. Piercing with three different clearances (1%, 5%, and 10% of sheet thickness) and speed of 4 m/s were performed. Additionally, conventional drilling was carried out at a feed rate of 0.2 m/min. The highest delamination factor difference between piercing and drilling processes was calculated as 7.3% and 13.9% for CFRP and AFRP, respectively. The highest burr amounts for AFRP and CFRP composites were obtained as 91.5% and 39% at 10% clearance for piercing process and 123% and 32.1% for drilling process, respectively. Compared with drilling, piercing generates less burr formation except for CFRP composites in the case of 10% clearance and more precise hole production. It is understood that piercing results significantly improve when smaller clearances up to 5% of the sheet thickness are utilized.
Qubit-oscillator relationships in the open quantum Rabi model: the role of dissipation
Authors: Di Bello G. , Cangemi L. M. , Cataudella V. , De Filippis G. , Nocera A. , Perroni C. A. 
Published: February 2023

Abstract
Using a dissipative quantum Rabi model, we study the dynamics of a slow qubit coupled to a fast quantum harmonic oscillator interacting with a bosonic bath from weak to strong and ultra-strong coupling regimes. Solving the quantum Heisenberg equations of motion, perturbative in the internal coupling between qubit and oscillator, we derive functional relationships directly linking the qubit coordinates in the Bloch sphere to oscillator observables. We then perform accurate time-dependent Matrix Product State simulations and compare our results both with the analytical solutions of the Heisenberg equations of motion, and with numerical solutions of a Lindblad master equation, perturbative in the external coupling between oscillator and environment. Indeed, we show that, up to the strong coupling regime, the qubit state accurately fulfils the derived functional relationships. We analyse in detail the case of a qubit starting with generic coordinates on the Bloch sphere of which we evaluate the three components of the Bloch vector through the averages of oscillator observables. Interestingly, a weak to intermediate oscillator coupling to the bath is able to simplify the Bloch vector evaluation since qubit-oscillator relationships are more immediate. Moreover, by monitoring the qubit fidelity with respect to free limit, we find the parameter regime where the combined effect of internal and external couplings is able to hinder the reliable evaluation of the qubit Bloch vector. Finally, in the ultra-strong coupling regime, non-Markovian effects become robust and the dynamics of qubit and oscillator are inextricably entangled making the qubit Bloch vector evaluation difficult.

Graphical Abstract
Spatiotemporal Variability of Tropical Cyclone–Induced Ocean Heat Uptake and Its Effect on Ocean Heat Content
Authors: Fan Kaigui , Wang Xidong , Liu Juan , Shao Caixia 
Published: February 2023

Abstract
Tropical cyclones (TCs) can pump heat downward into the ocean through inducing intense vertical mixing. Many efforts have been made to estimate the TC-induced ocean heat uptake (OHU), but spatiotemporal variability of TC-induced OHU remains unclear. This study estimates the TC-induced OHU, which takes into account the heat loss at the air–sea interface during TC passage compared to previous studies and investigates the spatiotemporal variability of TC-induced OHU and its potential impacts on ocean heat content (OHC) during the period 1985–2018. It is found that the spatial distribution of OHU is inhomogeneous, with the largest OHU occurring in the northwest Pacific, and category 3–5 TCs contribute approximately 51% of the total global OHU per year. The annually accumulated TC-induced OHUs in the regional basins exhibit pronounced interannual variability, which is closely related to the TC power dissipation index (PDI). By decomposing PDI into TC intensity, frequency, and duration, we find that the TC characteristics influencing OHU variability vary by basin. Correlation analyses suggest that the interannual variations of OHUs are linked to El Niño–Southern Oscillation (ENSO). In addition, the OHU might have the potential to influence OHC variability, especially in the equatorial eastern Pacific where there are significant positive correlations between the OHU and OHC with lags of 2–6 months. This has an important implication that TC-induced OHU might have potential effects on ENSO evolution.
Testing for lactase non-persistence in a Dutch population: Genotyping versus the hydrogen breath test
Authors: Stouten Karlijn , Wolfhagen Frank , Castel Rob , van de Werken Marjan , Klerks Johan , Verheijen François , Vermeer Henricus J 
Published: February 2023

Background Lactose intolerance is defined as the presence of gastrointestinal symptoms, such as bloating, abdominal pain or diarrhoea, after consumption of lactose in individuals with lactose malabsorption. Most cases involve primary lactose intolerance, caused by a loss of activity of the enzyme lactase, needed for digestion of lactose. A traditional method of establishing lactose intolerance is the hydrogen breath test (HBT), accompanied by a questionnaire to document complaints experienced by the patient during the test. Due to knowledge on lactase-persistent alleles, DNA genotyping has become available for the diagnostic work-up for lactose intolerance. Both methods are currently in use. The aim of this study is to provide a definite diagnostic approach for patients suspected of lactose intolerance in a Dutch population. Methods In this retrospective, observational study, patients aged 15 years or older were included after presenting to their treating physician with symptoms suggestive of lactose intolerance. HBT, including a questionnaire to document complaints and DNA genotyping of LCT-13,910 C/T was performed for each patient as part of a routine diagnostic work-up. Results 1101 patients were included (29% men). Positive and negative predictive value, sensitivity and specificity of HBT versus DNA genotyping were 80% (CI 75–84), 97% (CI 96–98), 89% (CI 84–92) and 94% (92–96) respectively. The use of the questionnaire added little diagnostic value. Conclusions In a population with a high prevalence of lactase-persistent alleles, we advise to exclude HBT from the diagnostic route for suspected lactose intolerance, and replace it with genotyping of lactase-persistent alleles.
Application of serum pools in insulin harmonization: Commutability and stability
Authors: Deng Yuhang , Zhang Chao , Wang Jing , Zeng Jie , Zhang Jiangtao , Zhang Tianjiao , Zhao Haijian , Li Miao , Zhao Yang , Gan Wei , Shao Yan , Yu Hongyuan , Zhou Weiyan , Zhang Chuanbao 
Published: February 2023

Background Recalibration using serum pools assigned by higher-order reference methods had been demonstrated to be effective in improving the agreement among insulin immunoassays. To promote the application of serum pools in insulin harmonization, this study analyzed serum pools’ commutability between insulin immunoassays, and their short- and long-term stability at different temperatures. The agreement between commonly used immunoassays was also evaluated. Methods Insulin in 69 individual serum samples, 10 serum pools, and three EQA samples (lyophilized powder of serum pools) were detected by six widely used immunoassays. The commutability of serum pools and EQA samples was evaluated according to the IFCC-recommended approach. Serum pools’ stability at different temperatures was investigated by placing them at various temperatures for varying lengths of time. Individual serum samples’ results were analyzed using the Bland–Altman and Passing and Bablok regression analyses. Results Serum pools were commutable among most assays, the EQA samples—lyophilized serum pools—were non-commutable among most assays. Serum pools can be stably stored at −20°C and −80°C for at least one year, but can only be stably stored at room temperature for twenty-four hours. Significant relative differences were observed among assays. Recalibration using serum pools can only improve the assays’ agreement at middle and high insulin levels, but not at low levels. Conclusions Serum pools were commutable and stable for insulin measurement and can be used in insulin harmonization. The existing EQA materials were non-commutable between most assays, and other EQA materials, such as serum pools, should be studied.
Long-Term Oral Steroid Use: A Unique Risk Factor in 4-Corner Fusion Compared With Other Wrist Salvage Operations
Authors: Newton William N. , Johnson Charles A. , Daley Dane N. , Daly Charles A. 
Published: February 2023

Introduction: Salvage procedures such as proximal row carpectomy, 4-corner fusion, total wrist arthroplasty, and total wrist arthrodesis are commonly used at the end stages of wrist arthritis. These operations have high complication rates, and significant controversy exists regarding the selection of procedure. Long-term oral glucocorticoid therapy has previously been identified as a risk factor for complications in multiple orthopedic procedures. The purpose of this study is to investigate the effect long-term oral preoperative corticosteroid use has on complications after different salvage operations for wrist arthritis. Methods: The National Surgical Quality Improvement Program database was queried to identify patients who underwent proximal row carpectomy, 4-corner fusion, total wrist arthroplasty, or total wrist fusion between 2005 and 2020. Patients were classified by steroid use. Univariate analysis and multivariate logistic regression were used to assess the risk of complications. Results: A total of 1298 patients were identified. Overall, steroid use was found to be independently associated with a higher complication rate. On multivariate analysis of patients who underwent 4-corner fusion, steroid use was found to be associated with higher complication rate and surgical site infection rate. Steroid use was not associated with increased complications in patients who underwent proximal row carpectomy, total wrist arthroplasty, or total wrist fusion when examined individually. Conclusion: Long-term oral corticosteroid therapy was associated with an increased risk of postoperative infections in patients who underwent 4-corner fusion, which was not found in other wrist salvage operations.
microRNA-181a contributes to gastric hypersensitivity in rats with diabetes by regulating TLR4 expression
Authors: Sun Qian , Zhang Shiyu , Zhang Bing-Yu , Zhang Yilian , Yao Lijun , Hu Ji , Zhang Hong-Hong 
Published: February 2023

Aim: The aim of this study is to investigate the mechanism and interaction of microRNA-181a (miR-181a), toll-like receptor 4 (TLR4) and nuclear factor-kappa B (NF-κB) in gastric hypersensitivity in diabetic rats. Methods: Diabetes was induced by a single intraperitoneal injection of streptozotocin (STZ; 65 mg/kg) in female SD rats. Gastric balloon distension technique was used to measure diabetic gastric hypersensitivity. Gastric-specific (T7-T10) dorsal root ganglion (DRG) neurons were acutely dissociated to measure excitability with patch-clamp techniques. Western blotting was employed to measure the expressions of TLR4, TRAF6 and NF-κB subunit p65 in T7-T10 DRGs. The expressions of microRNAs in T7-T10 DRGs were measured with quantitative real-time PCR and fluorescence in situ hybridization. Dual-luciferase reporter gene assay was used to detect the targeting regulation of microRNAs on TLR4. Results: (1) Diabetic rats were more sensitive to graded gastric balloon distention at 2 and 4 weeks. (2) The expression of TLR4 was significantly up-regulated in T7-T10 DRGs of diabetic rats. Intrathecal injection of CLI-095 (TLR4-selective inhibitor) attenuated diabetic gastric hypersensitivity, and markedly reversed the hyper-excitability of gastric-specific DRG neurons. (3) The expressions of miR-181a and miR-7a were significantly decreased in diabetic rats. MiR-181a could directly regulate the expression of TLR4, while miR-7a couldn’t. (4) Intrathecal injection of miR-181a agomir down-regulated the expression of TLR4, reduced the hyper-excitability of gastric-specific neurons, and alleviated gastric hypersensitivity. (5) p65 and TLR4 were co-expressed in Dil-labeled DRG neurons. (6) Inhibition of p65 attenuated diabetic gastric hypersensitivity and hyper-excitability of gastric-specific DRG neurons. (7) The expression of TRAF6 was significantly up-regulated in diabetic rats. CLI-095 treatment also reduced the expression of TRAF6 and p65. Conclusion: The reduction of microRNA-181a in T7-T10 DRGs might up-regulate TLR4 expression. TLR4 activated NF-κB through MyD88-dependent signaling pathway, increased excitability of gastric-specific DRG neurons, and contributed to diabetic gastric hypersensitivity.