bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENGEMBANGAN EKONOMI KREATIF DALAM MENINGKATKAN POTENSI PARIWISATA
Authors: Anom Pancawati Anom Pancawati , Rieka Yulita Widaswara  
Published: March 2023

Abstrak
Kreativitas usaha yang semakin tak terbatas secara tidak langsung mempengaruhi pemanfaatan sumber daya secara optimal dari yang tidak bernilai jual menjadi memiliki nilai ekonomis yang tinggi. Ekonomi kreatif merupakan salah satu usaha yang membutuhkan kreativitas, inovasi dan keterampilan dalam pengembangannya dan salah satu sistem pengembangan bisnis ekonomi kreatif adalah melalui UMKM. Ekonomi kreatif dan sektor pariwisata merupakan dua hal yang saling mempengaruhi, berkaitan satu dan lainnya yang jika dikelola secara optimal akan saling bersinergi sehingga mampu memberikan dampak positif terhadap pertumbuhan ekonomi dan kesejahteraan masyarakat. Penelitian ini bertujuan untuk mengetahui pengembangan ekonomi kreatif dalam meningkatkan potensi parwisata secara literatur. Metode yang digunakan analisis deskriptif dengan metode riset kepustakaan dari berbagai data berdasarkan referensi yang terkait dengan masalah yang diteliti. Hasil penelitian menunjukkan bahwa pengembangan ekonomi kreatif akan mampu mendukung transformasi ekonomi melalui penerapan ide-ide kreatif serta inovatif guna meningkatkan kesejahteraan masyarakat dan sektor pariwisata memegang peranan penting untuk menyatukan individu melalui kunjungan wisatawan dalam menggunakan kreativitas tersebut.
ANALISIS TINGKAT KESEHATAN BANK SYARIAH DENGAN MENGGUNAKAN METODE RISK-BASED BANK RATING (Studi Kasus BCA Syariah Tahun 2017-2021)
Authors: Zuraidah  , Khairul Wahid  
Published: March 2023

Penelitian ini bertujuan untuk mengetahui tingkat kesehatan bank syariah pada BCA Syariah dengan menggunakan metode Risk-based Bank Rating sesuai dengan POJK No. 8/POJK.03/2014 Tentang Penilaian Tingkat Kesehatan Bank Umum Syariah dan Unit Usaha Syariah. Bank diwajibkan untuk melakukan penilaian sendiri (self assessment) tingkat kesehatan bank menggunakan pendekatan risiko (Risk-based Bank Rating), dengan cakupan penilaian meliputi: Risk Profile (Profil Risiko), Good Corporate Governance (GCG), Earnings (Rentabilitas) dan Capital (Permodalan).
Penelitian ini menggunakan metode pendekatan kualitatif. Data yang diteliti merupakan data bersumber pada data sekunder laporan keuangan dan laporan pelaksanaan GCG pada BCA Syariah tahun 2017-2021. Teknik dan instrumen pengumpulan data menggunakan studi kepustakaan dan studi dokumentasi. Analisi data yang digunakan untuk mengetahui tingkat kesehatan bank dalam penelitian ini adalah analisis deskriptif dengan metode Risk-based Bank Rating.
Hasil penelitian menunjukkan tingkat kesehatan bank pada BCA Syariah dalam kurun waktu tahun 2017 hingga 2021 berada pada Peringkat Komposit 2 (PK-2) dalam kategori “Sehat”. Hal ini mencerminkan kondisi bank yang secara umum dalam kondisi sehat sehingga dinilai telah mampu menghadapi pengaruh negatif yang signifikan dan perubahan kondisi bisnis dan faktor eksternal lainnya.
Oppilaiden hyvinvointi poikkeusolojen etäopetuksessa
Authors: Koski Pasi , Keinänen Heli , Laakkonen Eero , Kärki Tomi , Kemppinen Lauri , Aerila Juli-Anna , Orell Miina 
Published: March 2023

Kouluissamme siirryttiin keväällä 2020 lyhyellä ennakkovalmistautumisella etäopetukseen koronapandemian vuoksi. Samaan aikaan asetettiin rajoituksia myös harrastustoiminnan ja yleisötilaisuuksien järjestämiselle sekä suljettiin julkisia tiloja. Nuorten arki muuttui keväällä äkillisesti ja arvaamattomasti. Tutkimuksessa tarkastellaan ala- ja yläkoulun oppilaiden sekä lukion opiskelijoiden poikkeusolojen aikaista hyvinvointia unen, ruokailun, liikunnan, vuorovaikutuksen, osallisuuden, yksinäisyyden ja kiusaamisen näkökulmista. Lisäksi selvitetään, miten nämä tekijät olivat yhteydessä heidän hyvinvointinsa muutokseen etäjakson aikana. Empiirisenä aineistona käytetään kevään ja kesän 2020 aikana oppilailta (n=970; peruskoululaiset ja lukiolaiset) kyselyjen avulla kerättyä tietoa. Tutkimustulosten perusteella etäjakson aikana tapahtui oppilaiden hyvinvoinnin eri osa-alueilla yleisemmin kielteisiä kuin suotuisia muutoksia. Oppilaat nukkuivat keskimäärin enemmän ja kiusaamista ilmeni vähemmän kuin normaalin koulunkäynnin yhteydessä, mutta muissa hyvinvoinnin osatekijöissä muutos ei ollut suotuisaa. Noin kolmannes vastanneista oppilaista arvioi hyvinvointinsa heikentyneen etäopetuksen seurauksena. Monet hyvinvointia heikentäneet piirteet olivat yhteydessä toisiinsa ja kasautuivat samoille nuorille. Arjen rutiinit ja niiden hallinta auttavat hyvinvoinnin säilyttämisessä. Asiasanat: etäopetus, hyvinvointi, pandemiat, nuoret
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Student well-being during distance learning during the COVID-19 emergency
In the spring of 2020, people’s daily lives changed suddenly and unpredictably due to COVID-19. This study examines the well-being of primary and secondary school students during the state of emergency from the perspectives of sleep, eating habits, physical activity, interaction, inclusion, loneliness, and bullying. In addition, the study explores how these factors were related to changes in student well-being during the school lockdown. The empirical data were collected from students (n=970; primary and secondary school students) during spring and summer 2020 by means of questionnaires. The results show that during the distance-learning period, negative changes in different aspects of students’ well-being were more common than positive ones. Approximately one-third of the respondents estimated that their well-being had deteriorated as a result of distance. Many of the characteristics that had a negative impact on well-being were interlinked and clustered among the same young people.
Keywords: distance learning, well-being, pandemic, youth
Roles of bacterial toxin receptor and piwi-interacting RNA of pacific white shrimp penaeus vannamei in response to vibrio parahaemolyticus-causing acute hepatopancreatic necrosis disease infection
Authors:   , Luangtrakul Waruntorn 
Published: March 2023

Acute hepatopancreatic necrosis disease (AHPND) or Early mortality syndrome (EMS) caused by virulent strains of Vibrio parahaemolyticus AHPND (VPAHPND) has been a leading cause of significant losses of shrimp production. In this study, we aim to explore the response and the role of immune-related gene/protein and small RNA in the VPAHPND-infected shrimp. This research was divided into 2 parts. In the first part, we identified candidate genes of VPAHPND toxin receptor and further confirmed its function as a VPAHPND toxin receptor. APN has been reported as a Cry toxin from Bacillus thuringiensis, whose structure is similar to VPAHPND toxin. Therefore, we identified aminopeptidase N (APN) from the transcriptomic data of VPAHPND-infected Litopenaeus vannamei hemocyte. According to LvAPN1 and LvAPN2 gene expression analysis, only LvAPN1 were highly upregulated in stomach, hepatopancreas and hemocyte after VPAHPND infection and VPAHPND toxin injection. Silencing of LvAPN1 gene reduced mortality, the clinical signs of AHPND in the hepatopancreas and the number of virulent VPAHPND bacteria in the stomach. In addition, observation of hemocyte morphology by scanning electron microscope showed that the LvAPN1 silencing prevented severe damage of hemocyte morphology causing by VPAHPND toxin like what clearly observed in the control group. At the protein level, rLvAPN1 directly bind to the recombinant protein of PirA and PirB toxins. Our results indicated that not only stomach and hepatopancreas, but also hemocytes are the target tissues of VPAHPND toxin and act as the VPAHPND toxin receptor. The second part aims to study on piRNAs that are expressed in response to VPAHPND infection. Firstly, we identified piRNAs from small RNA-Seq data of VPAHPND-infected L. vannamei. Totally 150 types of piRNA homologs were identified. Target gene identification of those piRNA identified 53 target genes involving in gene expression and protein synthesis/degradation. Six differentially expressed piRNAs (DEPs) were discovered. Two DEPs were upregulated whereas another 4 DEPs were downregulated after VPAHPND infection. Expression analysis of DEPs and the target genes showed that only 2 piRNAs such as piR-lva-29948104 and piR-lva-26449194 had the negative expression correlation with their mRNA targets which are E3 ubiquitin-protein ligase RNF26-like (RNF26) and circadian locomoter output cycles protein kaput-like (Clock), respectively. According to target gene’s function, these 2 piRNAs might play the role in gene expression and protein synthesis/degradation processes in VPAHPND-infected shrimp. Collectively, our study provides the new insight into the role of VPAHPND toxin receptor, LvAPN1, and the expression of piRNA in response to VPAHPND infection. This knowledge will provide alternative strategies for fighting against VPAHPND infection in shrimp farming.
Microfluidic system for detectingmalaria-infected red blood cells using impedance measurementcoupled with electromagnetic force
Authors:   , Sonridhi Prapapan 
Published: March 2023

Malaria is one of the most life-threatened diseases caused by Plasmodium parasite. Malaria is preventable and curable, mainly due to the factor of time and management of the spread. In other words, a rapid detection with high accuracy will contribute to more effective treatment process. In this research, we introduced the new technique implemented microfluidics, dealing with the manipulation of blood cells using magnetic force, and impedance measurement measuring the signal changes of electrical impedance between a couple of electrodes. According to the distinct magnetic properties of normal red blood cells and malaria-infected red blood cells, the experiment was designed to compare the impedance of these two blood types at the symmetrical distance along two outlets. One of which used electromagnetic field to pull malaria cells to flow into more than the other. By the capability of distinguishing the signal resolution, the differentiation of changes in impedance would refer to discriminated percentage parasitemia of malaria. From the preliminary experiment, our microfluidic channel could divide similar number of beads and amount of fluid volume for both outlets. When we applied electromagnetic field on only the side near one outlet, the number of magnet beads on that side is greater than the other. Moreover, impedance measurement was tested with various plastic bead density which is at 2x105, 3x105, and 6x105 beads/ml in static test, and 6x105, 7.5x105, and 1.5x106 beads/ml in dynamic test. These results shared the same trend that the resistance was greatly increased, while the reactance was gradually increased when the density was increased. Similarly, we used normal mouse blood, 10% and 44% parasitemia malaria-infected blood to be our experiment samples in both static and dynamic test. The results showed that the difference of signal between normal mouse blood, 10% and 44% malaria-infected blood could be discriminated when we applied electromagnet at 15V and 24V. In case of 44% malaria-infected blood, significant change in resistance and reactance was found which specially increased in the outlet where magnetic force was not applied. When applied magnetic field, the outlet without the magnetic force had less infected blood cells and lower cell density that has two countering effects on the impedance in such a way that higher and lower resistance would be obtained, respectively. From our experiments, the results suggested the stronger influence of blood type on the impedance as the total resistance increases at this outlet. In the future, after the further development, we hope that the impedance different ratio would more precisely translate into the percentage parasitemia.
Development of nanoparticle-in-microsphere(Nimos) system for oral delivery of vaccine and antibody against ped virus for swine
Authors:   , Junchay Rachatapan 
Published: March 2023

PED virus is a major barrier to the animal farming industry, and it is the main cause of the mortality of suckling piglets up to 95% by enteric infection. The 2C10 monoclonal antibody (mAb) obtained from Nicotiana benthamiana produced by transient expression was indicated as one of the potential candidates is an antibody against PEDV by oral delivery. The biologics are a new wave of pharmaceuticals and have been continuously developing, which has various benefits of low toxicity and high specificity. However, it unsuitable for use with oral drug delivery owing to limitations of the strong acidity and protease of the GI tract. Therefore, to overcome these limitations, the development of oral drug delivery is essential for biologics to enhance stability. The pH-responsive microbeads were used as a carrier for oral delivery and the alginate-chitosan is a well-known material, some properties protect biologics from an inappropriate environment of the GI tract. The concentration of alginate-chitosan was optimized for pH-responsive beads construction, which the 2% alginate and 1% chitosan is a suitable qualification. Then the physical characterization of pH-responsive microbeads includes the diameter size measurement by digital vernier, found that the distribution of diameter size was between 1.5-1.6 mm which was more than 70%. The SEM showed that the surface of pH-responsive microbeads was a network structure with varying porosity, meanwhile, the TEM demonstrates to the nanoparticles kept in microbeads. Further, the release behaviour for pH-responsive microbeads in simulated physiological fluids (SPF) was investigated under a fluorescent microscope, it was found that the pH-responsive microbeads could protect and retain the nanoparticles from SPF. In the last step, the biologics encapsulated with microbeads were tested with SPF, after that, it evaluated the efficacy by Real-Time PCR. From the result, both the viral-like particles and the 2C10 mAb still stable, even though, was tested with SPF. In summary, the alginate-chitosan is efficient enough to retain the nanoparticles, and the pH-responsive microbeads can use as a carrier for oral drug delivery owing to could be protected from an acidic environment and released the nanoparticles to the target area.
Drought tolerant gene identification by rice genome comparison and gene characterization in arabidopsis plant model
Authors:   , Punchkhon Chutarat 
Published: March 2023

Abiotic stresses, especially drought and salt stresses can affect plant growth and productivity. ‘Kao Dawk Mali 105’ (‘KDML105’) rice is one of the crops which has to face both drought and salt stresses as it is grown in rain-fed saline soil in the northeastern region of Thailand, where the irrigation is limited. CSSL104, a chromosome substitution line with ‘KDML105’ genetic background, was developed in order to improve drought tolerant ability of ‘KDML105’ rice by transferring the drought tolerant (DT)-QTL region from double haploid line, DH103. Photosynthesis parameters of CSSL104 and its parental lines, ‘KDML105’ and DH103, were investigated, when they were grown in normal and drought-stress conditions. Net photosynthesis rates of all lines were similar in normal condition. In drought stress, net photosynthesis rate of all lines was declined, but CSSL104 and DH103 rice had the significant higher photosynthetic rate than ‘KDML105’ rice under drought-stressed condition. Based on the SNPs comparison between CSSL104 and ‘KDML105’ rice and gene co-expression network analysis, nine genes were involved in photosynthesis and six genes from those genes were used to study in Arabidopsis mutant lines containing the mutation in the homologous genes of the predicted ones. The mutant lines containing the mutation in LOC_Os01g72950, LOC_Os07g37550, LOC_Os07g38300, and LOC_Os10g10170 showed better growth than wild type (WT) under drought stress. The expression of LOC_Os07g37550 and LOC_Os08g41460 in ‘KDML105’ was higher than the expression in CSSL104 and DH103 under drought stress. It supported the result of net photosynthesis that ‘KDML105’ was more susceptible to drought stress than CSSL104 and DH103. Therefore, it was proposed that these genes were involved in drought tolerant mechanism in CSSL104.

The predicted drought tolerance genes from CSSL104, Ndh-O, Lhcb3, Rrf, Pgrl5-like, LOC_Os09g39390, Mrl1, together with LOC_Os01g68450, the predicted salt tolerance gene from CSSL16 were evaluated for salt tolerance involvement by using the Arabidopsis mutant lines containing the mutation in the homologous genes of the predicted ones. At1g65230 is orthologous to LOC_Os01g68450 gene in rice and at1g65230 Arabidopsis mutant performed the highest growth inhibition under salt stress condition when compared to other mutant lines. The revertant and ectopic expression lines with LOC_Os01g68450 gene show the higher growth parameters than the at1g65230 mutant under drought and salt stress. Moreover, the ectopic expression lines showed high net photosynthesis and pigments content under salt stress. These suggested that LOC_Os01g68450 gene has a function to maintain pigments contents under drought and salt stress leading to the photosynthesis adaptation during drought and salt stress.
Phytoalexin and biomarker peptide detection using mass spectrometry
Authors:   , Komkleow Sasikarn 
Published: March 2023

Mass spectrometry (MS) has been one of the scientific techniques most commonly used in different areas. Therefore, the current research was carried out in order to investigate the role of MS in biological analysis. This study is divided into two main parts. The first part used MS imaging to reveal the ability of the technique for imaging metabolites directly from plant tissue. Thai rice varieties were used to investigate the production and distribution of diterpenoid phytoalexins using matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI). Results revealed the successfully detection of 5 types of diterpenoid phytoalexins on RD6 rice leaf tissue, including momilactone-A (m/z 353.17), momilactone-B (m/z 369.16), phytocassane-A/D/E (m/z 355.18), phytocassane-B (m/z 373.19) and phytocassane-C (m/z 357.20). In the second part, MS technique was used to assess the consequence of prolonged nicotine treatment on the invasion of A549 non-small cell lung cancer cell line by label-free quantitative proteomic analysis. Proteins were collected from both the monolayer and the invasion systems to investigate the alteration in protein expression. Fifty five proteins from the monolayer system and 100 proteins from the invasion system were identified with a change in expression level after prolonged nicotine treatment. Western blotting was then employed to validate the candidate proteins. The results indicated that prolonged exposure of nicotine promoted invasion on A549 cells. Interestingly, legumain, heat shock protein HSP 90-alpha, heat shock related 70 kDa protein 2, protein disulfide isomerase A3 and profilin-1 were found to show higher expression in A549 cells after prolonged exposure to nicotine. These findings testify to the power of mass spectrometry in biological molecule detection, allowing the discovery of novel information in the future.
Potential of antimicrobial peptides against bacterial pathogens causing bovine mastitis
Authors:   , Popitool Kwantida 
Published: March 2023

Bovine mastitis is a common disease in dairy cows. The majority causes of bovine mastitis disease is an intramammary bacterial infection via the teat orifice. In general, antibiotics are used for bovine mastitis treatment, its inappropriate usage leads to antibiotic-resistance problem and residue in meat and dairy products. One of the alternative ways against pathogen to reduce antibiotic usage is antimicrobial peptides which are innate immune of life. Three cationic peptides as Pm11, Pep64, and L10 peptides were evaluated for an antimicrobial activity to gram-positive and gram-negative bacteria. Pm11 has shown the best potent antimicrobial activity with minimum bactericidal concentration (MBC) range from 2.5-10.0 µM and IC50 0.32-2.07 µM. Time kill kinetics of Pm11 peptide against bovine mastitis pathogens were ascertained, Pm11 is exhibited strong activity to completely killing Streptococcus agalactiae (SCM1084), Streptococcus uberis (SCM1310) within 1 hour and completely killing Staphylococcus aureus (CM967), Escherichia coli (SCM1249) within 4 hour. However, Pm11 peptide at 10.0 µM could not be completely killing Klebsiella spp. (SCM1282), even though 3 log10 CFU/ml of Klebsiella spp. (SCM1282) was decreased within 2 h, but it was returning to grow up within 12 h. Visual observation under the scanning electron microscope of Pm11 peptide attacked to the pathogens shown the distinct morphological changes. The cytotoxicity assay confirmed that Pm11 peptide at the concentration 0 to 160 µM had low hemolytic activity to sheep red blood cells. Nonetheless, the antimicrobial activity of Pm11 peptide was reduced in UHT milk.
The impact of internet finance on the profitability of commercial banks in China
Authors:   , Song Yuting 
Published: March 2023

Several studies analyzed the impact of internet finance on the profitability of Chinese commercial banks. This paper adds to the literature by focusing on two types of internet finance, internal internet finance (online banking) and external internet finance (third-party-payment (TPP) and peer-to-peer lending (P2P) platforms), and their relationship with bank performance. Two datasets that cover the years 2011 to 2018 are used for the regression analyses, a balanced panel dataset of 10 banks to analyze the impact of internal and external internet finance on bank performance and an unbalanced panel dataset of a larger sample of 43 banks to further explore the impact of external internet finance on commercial bank performance. The regression results suggest that online banking reduced the profitability of banks, which might be explained by increased cost in terms of operation, marketing and maintenance as well as upgrading of infrastructure. TPP growth also negatively affected bank profitability, which might indicate that TPP increases competition. The rapid growth of P2P, on the other hand, had a positive effect on bank performance, probably because of technology spillover effects from internet companies. To increase profitability, besides controlling cost, commercial banks should improve online channels and win-win cooperate with EIF enterprises to take advantage of technology spillover effect.
Deactivation of PdNi catalyst on nanoporous carbon support derived from cattail leaves in synthesis of partially hydrogenated biodiesel(h-fame)
Authors:   , Longprang Tripob 
Published: March 2023

Nowadays, biodiesel is an alternative energy that is widely used to replace fossil fuels because of its high heat value comparable to fossil fuels. Biodiesel was easily oxidized within air. It is commonly blended with diesel fuel to have the proper properties and increase shelf life. Partial hydrogenation is one of the processes used to enhance the properties of biodiesel. In this research, bimetallic PdNi on nanoporous carbon (NPC) support derived from cattail leaves was successfully synthesized via hydrothermal carbonization and chemical activation. The prepared nanoporous carbon has a high surface area of ​​2002 m2g-1, obtained by activation process with 4 M of potassium hydroxide at 900 °C. Optimal condition and deactivation of PdNi/NPC in partial hydrogenation at various temperatures (80, 100, 120 and 140 ° C), pressure (3, 4 and 5 bar) and stirring rate (150, 200 and 300 rpm) were investigated. It was found that an operation at 100 °C, 4 bar and a stirring speed of 150 rpm offered the biodiesel with increased oxidation stability to 18.34 h. Furthermore, the results indicated that the deactivation of catalyst occurred from two main factors: poisoning of sulfur molecules in biodiesel feedstock and carbon residue covering on the surface of the catalyst. The addition of nickel in the bimetallic form led to increased cis-C18:1 selectivity and decreased the catalyst deactivation in the partial hydrogenation process.