bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of cuproptosis-related genes for predicting the development of prostate cancer
Authors: Wang Xin’an , Chen Xi , Xu Chengdang , Zhou Weidong , Wu Denglong 
Published: September 2023

Abstract
Copper can be toxic at very high intracellular concentrations and can inhibit prostate cancer (PCa) progression. Recently, a study reported the mechanism of cuproptosis and the potentially associated genes. However, the function of these cuproptosis-related genes in PCa remains unknown. Based on the RNA sequence and clinical data from public databases, we analyzed the clinical value of cuproptosis-related genes in PCa. DLD, DLAT, PDHA1, and CDKN2A were expressed differently between normal and PCa tissues. The FDX1, LIAS, DLAT, GLS, and CDKN2A genes can affect PCa progression, while PDHA1 and CDKN2A influence the patients’ disease-free survival (DFS) status. The expression of LIAS, LIPT1, DLAT, and PDHB did not alter upon the incidence of PCa in Chinese patients. A constructed regression model showed that FDX1, PDHA1, MTF1, and CDKN2A can be risk factors leading to PCa in both Western and Chinese patients with PCa. The lasso regression model reflected that these genes can affect the patients’ DFS status. Additionally, the cuproptosis-related genes were associated with immune cell infiltration. We also verified the high expression of PDHA1 and CDKN2A, in clinical samples. In conclusion, we identified a novel cuproptosis-related gene signature for predicting the development of PCa.
LGBTQ youth mental health and COVID: where we are & next steps
Authors: Ormiston Cameron K. 
Published: September 2023

Abstract
Lesbian, gay, bisexual, transgender, and queer/questioning (LGBTQ) youth bear a disproportionate burden of mental health difficulties during the COVID-19 pandemic relative to non-LGBTQ youth due to systemic disadvantages and barriers that LGBTQ youth uniquely face. Efforts in the US to minimize the pandemic’s impact are inadequate or impeded by a growing wave of anti-LGBTQ sentiment and legislation. As such, public health and policy play a crucial role in implementing necessary systemic change.
Psychische Belastungen bei der Arbeit erfassen und bewerten: Aktuelle Herausforderungen
Authors: Faller Gudrun 
Published: September 2023

Zusammenfassung
Der vorliegende Beitrag beschäftigt sich mit den konzeptionellen und methodischen Herausforderungen, die sich im Kontext der Gefährdungsbeurteilung psychischer Belastungen für Betriebe stellen, und reflektiert den Diskussionsstand zum Umgang mit entsprechenden Barrieren.
Schutz und Förderung mentaler Gesundheit in der Arbeitswelt
Authors: Beck David , Wegewitz Uta , Hegewald Janice 
Published: September 2023

Zusammenfassung
In der Arbeitswelt besteht erhebliches Potenzial, durch Maßnahmen des Arbeitsschutzes, betrieblicher Gesundheitsförderung, Früherkennung und Wiedereingliederung wirksam zum Schutz mentaler Gesundheit beizutragen. Anforderungen an präventive Arbeitsgestaltung sind im Rahmen der Gemeinsamen Deutschen Arbeitsschutzstrategie konkretisiert worden. Für die Weiterentwicklung ist auch der Ausbau empirisch fundierten Wissens über Möglichkeiten und Bedingungen betrieblicher Präventionspraxis erforderlich.
Regionale Deprivation und Entwicklungsverzögerung bei Kindern
Authors: Hoffmann Stephanie , Spallek Jacob 
Published: September 2023

Zusammenfassung
Die psychische Gesundheit junger Menschen hängt mit ihrer psychosozialen Entwicklung (z. B. Sprache) zusammen, für die Unterschiede anhand sozioökonomischer Bedingungen der Familie beschrieben werden. Die Deprivation der Wohnregion ist additiver Risikofaktor für die kindliche Entwicklung (ORweibl. = 1,35[1,13–1,62]; ORmännl. = 1,20[1,05–1,39]). Beide sind von besonderem Interesse für Public Mental Health und Förderung der Gesundheit von Kindern in der frühen Kindheit und im Lebensverlauf.
Mental Health Surveillance in Deutschland
Authors: Walther Lena , Mauz Elvira , Hölling Heike , Thom Julia 
Published: September 2023

Zusammenfassung
Mit der Etablierung der psychischen Gesundheit als Public-Health-Thema wird auch ihre Surveillance (Überwachung) gefordert. Am Robert Koch-Institut ist daher eine Mental Health Surveillance für Deutschland im Aufbau. Die fortlaufende und systematische Beobachtung zentraler Indikatoren der psychischen Gesundheit der Bevölkerung mit einer regelmäßigen Berichterstattung soll verlässliche Aussagen über Entwicklungen liefern und somit eine wichtige Informationsgrundlage für die Public-Health-Praxis bieten.
Populationsbasierte Interventionen im Bereich Public Mental Health
Authors: Rauschenberg Christian , Hartmann Jessica , Reinhold Annika Stefanie , Schick Anita , Reininghaus Ulrich 
Published: September 2023

Zusammenfassung
Dieser Artikel hat zum Ziel, einen Überblick über drei zentrale Strategien populationsbasierter Interventionen der Public Mental Health darzustellen: (1) Hochrisikostrategie, (2) Populationsstrategie und der (3) vulnerable Populationsansatz. Dabei werden zentrale Herausforderungen beleuchtet und die Bedeutung inter- und transdisziplinärer Zusammenarbeit hervorgehoben. Zukünftige Maßnahmen der Public Mental Health erfordern die Integration dieser Strategien unter Beteiligung von Betroffenen und Stakeholdern.
Men’s Sheds (Männerschuppen) - Treffpunkte für ältere Männer
Authors: Bardehle Doris 
Published: September 2023

Zusammenfassung
Seit der Jahrtausendwende haben Men’s Sheds in vielen Ländern Einzug gehalten und die Bereitschaft der Männer zur aktiven Mitgestaltung genutzt, um deren Gesundheitsbewusstsein zu verbessern und so das Wohlbefinden zu steigern. Über den aktuellen Stand von Men’s Sheds in Deutschland wurde recherchiert und Beispiele werden vorgestellt.
Die Bedeutung der Kommune für die psychische Gesundheit von Geflüchteten
Authors: Nowak Anna Christina 
Published: September 2023

Zusammenfassung
Die Prävalenz von psychischen Erkrankungen bei geflüchteten Menschen und Asylsuchenden ist hoch. Als relevante Determinanten für die mentale Gesundheit beschreibt die Literatur u.a. Postmigrationsstressoren, die zudem zu gesundheitlicher Ungleichheit beitragen können. Der vorliegende Artikel argumentiert, dass integrationspolitische Maßnahmen auf kommunaler Ebene die gesundheitlichen Auswirkungen der Lebenslage von Menschen mit Fluchtgeschichte beeinflussen können.
Public Mental Health in der Klimakrise
Authors: Rottke Daniel , Cirstea Aleksandra , Bokhof Beate , Liebau Laura Dorothea , Pöhlmann Lena , Knebusch Veronika 
Published: September 2023

Zusammenfassung
Die Klimakrise und konsekutive Extremwetterereignisse sowie drohende Ressourcenknappheit sind nicht nur eine Gefahr für das physische Wohlbefinden, sondern bergen auch hohe Risiken für die mentale Gesundheit, welche vor allem für marginalisierte Gruppen zunehmende Vulnerabilität bedeutet. Diesen Risiken mitigativ sowie adaptiv entgegenzuwirken, muss im Sinne von Public Mental Health als globale, gesamtgesellschaftliche Aufgabe adressiert werden.
Notes on two contemporary myths: free internet and user activity on digital social networking sites
Authors: Santos Marcelo 
Published: September 2023

AbstractThe proposal presented here opens up the opportunity to discuss what attentive Barthesian eyes can tell us about this early twenty-first century. We discuss the following research question: If actors pay nothing to be on digital social networking sites, and if they are supposed to shape the digital environment, how do companies profit if such an assumed logic remains for them a subordinate place? The answer could not be more Barthesian. The culture of platforms, transformed into nature, mythifies digital life, pointing to the success of the capitalistDoxa: the internet is free and the users are the agents of the network, while in reality, platforms earn millions, and users are manipulated by dishonest product sales strategies and by the spread of fake news.
An interventional study of baicalin on neuronal pentraxin-1, neuronal pentraxin-2, and C-reactive protein in Alzheimer’s disease rat model
Authors: Zhao Jing-Kun , Hou Si-Jia , Zhao Ji-Wei , Yu Hong-Li , Duan Shu-Rong 
Published: September 2023

Abstract

Background
Baicalin has been shown to promote spatial learning and neural regeneration, which might increase the differentiation of neural stem cells in Alzheimer’s disease (AD) rat models. We aimed to study the role of baicalin on neuronal pentraxin-1 (NPTX-1), neuronal pentraxin-2 (NPTX-2), and C-reactive protein (CRP) in AD model rats.

Methods
The 30 male Sprague Dawley rats were divided into three groups: the control group, the AD model group, and the AD + baicalin group. Then, the Morris water maze was used to verify the effect of baicalin on the memory and spatial learning of rats. Immunohistochemistry and immunofluorescence were used to observe the expression of NPTX-1, NPTX-2, and CRP in brain tissue.

Results
Compared with the AD model group, the AD rats treated with baicalin spent significantly less time finding escape latencies (P = 0.008) and had longer cross-platform times in the target quadrant (P = 0.015). In addition, the AD + baicalin group had significantly higher numbers of hippocampal neurons compared with the AD model group (P < 0.05). Baicalin also obviously decreased the apoptosis of neurons. Moreover, compared with the AD model group, the NPTX-1 and CRP expression in the AD + baicalin group was significantly reduced (P = 0.000) while the expression of NPTX-2 in the brain tissue of AD rats was significantly increased (P = 0.000).

Conclusions
Baicalin can play a therapeutic role by downregulating NPTX-1, upregulating NPTX-2, and downregulating CPR in AD model rats.
Strength-Deformation Characteristics of Two Different Foamed Glass Aggregates under a Static Design Load
Authors: Nicks Jennifer E. , Ghaaowd Ismaail I. , Adams Michael T. 
Published: September 2023

Abstract
Foamed glass aggregates (FGAs) are an emerging material in the US for use as a lightweight structural backfill. Manufactured from recycled glass powder mixed with a foaming agent, FGAs are considered a sustainable solution with advantageous engineering properties noted throughout the literature. For load-bearing applications, their long-term deformation behavior under typical, in-service static design loads is not as well understood, nor is its impact on shear strength. To address this gap in knowledge, the Federal Highway Administration conducted long-term (28-day) compression and direct shear tests on two different FGAs: one manufactured through a wet foaming process (FGA-1) and the other through a dry process (FGA-2). The compression tests were performed on both compacted and uncompacted specimens under 82.7 kPa of applied pressure in a large-scale direct shear (LSDS) device used as a consolidometer; both dry and submerged conditions were evaluated for the compacted specimens. LSDS tests were then conducted immediately after the 28-day compression, as well as after a short consolidation phase. The experimental program also included sieve analysis, relative density, absorption, and aggregate imaging. To serve as a basis for comparison, a conventional backfill, classified as a No. 8 stone, was similarly tested. The findings showed that the physical properties and deformation characteristics of the two FGAs were not the same, with FGA-1 experiencing significantly more vertical strain than FGA-2, which behaved similarly to the No. 8 backfill. All materials exhibited comparable peak shear strengths; however, the FGAs exhibited more ductile behavior. In addition, the changes in the gradation and shape characteristics after each test are presented. The particle size and brittleness of FGAs presented challenges when strictly applying and interpreting standard test procedures developed for soils, which are discussed as well. The overall results suggest that FGAs are a unique but viable substitute for sustainable geotechnical applications.
A method to detect fulvestrant interference in estradiol in breast cancer patients
Authors: Brito Margarida , Prazeres Susana , Malheiros Marta 
Published: September 2023

Background
Fulvestrant resembles estradiol in its structure. Reports have been published concerning fulvestrant measured as estradiol by the immunoassays. This may induce falsely elevated estradiol results and wrongly impact medical decisions. Our aim was to confirm the interference of fulvestrant on estradiol concentration and test a method to identify the false results.

Methods
Four serum samples with low estradiol levels were spiked with fulvestrant at various concentrations. Estradiol was then measured directly on serum (Dir), after a 1:5 dilution (Dil), and a ratio Dil/Dir was estimated. On the second part of the study, estradiol results (Dir, Dil and ratio Dil/Dir) from 14 women treated with fulvestrant were analysed, as well as from 14 patients not under this treatment.

Results
The addition of exogenous fulvestrant to the serum samples induced a gradual rise on estradiol concentration with a mean ratio for the Dil/Dir samples of 2.1 ± 0.4 (range 1.7–2.9). Patients on fulvestrant treatment experienced a mean ratio for the Dil/Dir estradiol sample of 2.4 ± 0.4 (range 1.6–3.0). In the control group, a mean estradiol ratio Dil/Dir of 1.1 ± 0.1 was observed (range 0.8–1.3). No correlation between the number of days after fulvestrant injection and estradiol result (r = 0.531) was observed.

Conclusion
Our study confirmed the interference of fulvestrant in the estradiol measurement by immunoassay. When fulvestrant was present, the estradiol ratio for Dil/Dir sample was about 2. In the control group, the ratio was around 1. The estradiol Dil/Dir ratio is a simple tool which can be used to identify fulvestrant false immunoassay estradiol results.
ЕКСПЕРИМЕНТАЛЬНА ПЕРЕВІРКА ЕФЕКТИВНОСТІ ПЕДАГОГІЧНИХ УМОВ ФОРМУВАННЯ ЗДОРОВ’ЯЗБЕРЕЖУВАЛЬНОЇ КОМПЕТЕНТНОСТІ МАЙБУТНІХ УЧИТЕЛІВ ПОЧАТКОВИХ КЛАСІВ
Authors: БАЛУХ МИКОЛА 
Published: September 2023

У статті зроблено акцент, що професійна підготовка майбутніх учителів початкових класів неможлива без формування їхньої здоров’язбережувальної компетентності, що значною мірою залежить від визначення рівнів їхніх фахових компетентностей і відповідних критеріїв. Доведено, що оцінювання рівнів фахових компетентностей майбутнього вчителя є суб’єктивним і відображає позицію дослідника означеної проблеми.
Авторами розкрито хід експериментальної перевірки педагогічних умов формування здоров’язбережувальної компетентності майбутніх учителів початкових класів у процесі професійної підготовки в педагогічному закладі вищої освіти. Розкрито компоненти і критерії сформованості відповідних рівнів здоров’язбережувальної компетентності, визначено три рівні розвитку останньої.
Встановлено, що здоров’язбережувальна компетентність розвивається від одного рівня до іншого, а її діагносттика здійснюється відповідно до структури, показників і критеріїв визначення рівнів сформованості її компонентів.
СТАВЛЕННЯ СТУДЕНТІВ ДО РІЗНИХ ФОРМ ОРГАНІЗАЦІЇ НАВЧАННЯ
Authors: ГУРАЛЬ ІНЕСА , СМОЛОВИК ЛІАНА 
Published: September 2023

У статті проаналізовано результати опитування студентів Івано-Франківського національного технічного університету нафти і газу (ІФНТУНГ) щодо використання різних форм організації навчання: традиційного очного, змішаного та дистанційного. Зроблено висновки про те, що пріоритетні формати навчання студентів відрізняються як для різних напрямів підготовки, так і різних вікових категорій. Авторами доведено, що студенти різних напрямів підготовки мають подібні погляди щодо вибору організації навчання для більшості дисциплін, за винятком математики та іноземної мови, а студенти молодших курсів для вивчення більшості дисциплін надають перевагу очному та змішаному форматам, а старших курсів – дистанційному. Узагальнено, що вибір студентами оптимального формату навчання залежить від усіх досліджених ознак.
Results of a pilot clinical trial of the safety and efficacy of an original glycoprotein IIb/IIIa receptor inhibitor in acute coronary syndrome
Authors: Lukyanov S. V. , Glukhov Yu. F. , T. E. V. , Tankhilevich B. M. , Zateyshchikov D. A. , Khlevchuk T. V. , Bondareva I. B. 
Published: September 2023

Aim. To study the safety and efficacy of Angipure in acute ST-segment elevation coronary syndrome (STE-ACS) and high-risk percutaneous transluminal coronary angioplasty (PTCA) compared with eptifibatide.Material and methods. The study included 157 patients with STE-ACS. High-risk PTCA included massive or total coronary artery thrombosis, noreflow/slow-reflow phenomenon, and acute stent thrombosis. Fifty-five people received Angipure at a dose of 0,72 mg/kg, 52 — at a dose of 0,40 mg/kg, while 50 patients received eptifibatide (Integrilin). We conducted clinical and laboratory studies, electrocardiography (ECG), coronary angiography.Results. According to the criteria "Frequency and severity of hemorrhagic events, including hemorrhagic stroke", "Frequency, severity of other adverse events", there were no differences in safety between Angipure at doses of 0,40 and 0,72 mg/kg and eptifibatide. Complaints, clinical symptoms, vital signs, complete blood count, biochemical and coagulation tests, ECG in patients of different groups were similar and had unidirectional dynamics. The use of Angipure or eptifibatide was considered effective if no adverse outcomes (death, recurrent acute ischemic event, need for urgent revascularization) were observed within 30 days. There were no lethal outcomes. One repeated acute ischemic event was registered in each group. In groups of patients receiving Angipure 0,40 mg/kg and eptifibatide, urgent revascularization was required once each.Conclusion. Angipure and eptifibatide have similar safety and efficacy.
Electrolyte Disorders in Mitochondrial Cytopathies: A Systematic Review
Authors: Viering Daan H.H.M. , Vermeltfoort Lars , Bindels René J.M. , Deinum Jaap , de Baaij Jeroen H.F. 
Published: September 2023

Significance Statement
Several recent studies identified mitochondrial mutations in patients with Gitelman or Fanconi syndrome. Mitochondrial cytopathies are generally not considered in the diagnostic workup of patients with electrolyte disorders. In this systematic review, we investigated the presence of electrolyte disorders in patients with mitochondrial cytopathies to determine the relevance of mitochondrial mutation screening in this population. Our analysis demonstrates that electrolyte disorders are commonly reported in mitochondrial cytopathies, often as presenting symptoms. Consequently, more clinical attention should be raised for mitochondrial disease as cause for disturbances in electrolyte homeostasis. Further prospective cohort studies are required to determine the exact prevalence of electrolyte disorders in mitochondrial cytopathies.

Background
Electrolyte reabsorption in the kidney has a high energy demand. Proximal and distal tubular epithelial cells have a high mitochondrial density for energy release. Recently, electrolyte disorders have been reported as the primary presentation of some mitochondrial cytopathies. However, the prevalence and the pathophysiology of electrolyte disturbances in mitochondrial disease are unknown. Therefore, we systematically investigated electrolyte disorders in patients with mitochondrial cytopathies.

Methods
We searched PubMed, Embase, and Google Scholar for articles on genetically confirmed mitochondrial disease in patients for whom at least one electrolyte is reported. Patients with a known second genetic anomaly were excluded. We evaluated 214 case series and reports (362 patients) as well as nine observational studies. Joanna Briggs Institute criteria were used to evaluate the quality of included studies.

Results
Of 362 reported patients, 289 had an electrolyte disorder, with it being the presenting or main symptom in 38 patients. The average number of different electrolyte abnormalities per patient ranged from 2.4 to 1.0, depending on genotype. Patients with mitochondrial DNA structural variants seemed most affected. Reported pathophysiologic mechanisms included renal tubulopathies and hormonal, gastrointestinal, and iatrogenic causes.

Conclusions
Mitochondrial diseases should be considered in the evaluation of unexplained electrolyte disorders. Furthermore, clinicians should be aware of electrolyte abnormalities in patients with mitochondrial disease.
The Upregulation of miR-22 alleviates oxygen–glucose deprivation/reperfusion-induced injury by targeting Tiam1 in SH-SY5Y cells
Authors: Yin Jiansong , Wan Yu , Wang Jing , Xue Mei 
Published: September 2023

MicroRNA-22 (miR-22) has been reported to exert a neuroprotective effect. However, the specific role and mechanism of miR-22 in ischemia/reperfusion (I/R)-induced brain injury are still not known well. In this study, we evaluated whether miR-22 participates in I/R-induced neuronal injury and the potential mechanism by using an oxygen-glucose deprivation/reperfusion (OGD/R) model in vitro. Our results showed that miR-22 was significantly down-regulated in SH-SY5Y cells suffering from OGD/R. Up-regulation of miR-22 by its specific mimic could protect SH-SY5Y cells against OGD/R-induced injury. The luciferase reporter assay demonstrated that T-cell lymphoma invasion and metastasis 1 (Tiam1) was a direct target of miR-22. MiR-22 mimic obviously inhibited Tiam1 expression in OGD/R-exposed SH-SY5Y cells. Tiam1 siRNA could attenuate OGD/R-induced SH-SY5Y cell injury. In addition, Tiam1 siRNA reduced the activation of Ras-related C3 botulinum toxin substrate 1 (Rac1) in OGD/R-exposed SH-SY5Y cells, and up-regulation of Rac1 activity could attenuate the neuroprotective effect of miR-22 up-regulation. Furthermore, OGD/R exposure led to increased methylation of miR-22, and the demethylating agent 5-Aza-dC significantly up-regulated miR-22 expression and inhibited Tiam1 expression and Rac1 activation. Taken together, our results demonstrated that DNA methylation-mediated miR-22 down-regulation aggravated I/R-induced neuron injury by promoting the activation of Tiam1/Rac1 signals. Our findings provide a deeper understanding of I/R-induced brain injury and suggest that miR-22 may be a promising therapeutic target for this disease.
Bionics investigation of blood 25-hydroxyvitamin D in the interpretable biomechanics diagnosis of childhood anemia
Authors: Zhang Lechi , Huang Aijie , Cai Jingye , Hou Jiangting , Deng Hongyan , Liu Chenxiao 
Published: September 2023

Vitamin D deficiency (VDD) causes a wide range of health problems, including anemia in infants. If not treated promptly, it may create serious issues for infants with long-term impacts. Therefore, a satisfactory solution to this problem is required. This investigation was to explore the correlation between the blood 25-hydroxyvitamin D (25(OH)D) levels and childhood anemia. In this investigation, a cross-sectional examination was performed on 2,942 babies ranging in age from 2 to 36 months and classified into three cohorts: VDD (Vitamin D deficiency), VDI (Vitamin D insufficiency), and VDS (Vitamin D sufficiency). Multiple-variables and multinomially-related logistic regressions for examining the anemia status-vitamin D (Vit-D) relationship of the baseline as the interpretable visual quality models were examined. The median serum 25(OH)D level in 2,942 infants was 24.72±4.26 ng/l, with 661 cases (22.5%) of VDD and 1710 cases of deficiency (58.1%), and a noticeable seasonal variation (p<0.05). Anemia was present in 28.5% of the VDD group compared with 3.3% in vit-D sufficient infants (p<0.0001). Lower levels of 25(OH)D were found to be associated with an increased risk of anemia in a multiple-variable regression analysis. In healthy children, low 25(OH)D levels were associated with increased risk of anemia. Biologically inspired, primary care physicians should assess Vit-D levels and place a greater emphasis on adequate supplementation for deficiency prevention.