bluuebunny/crossref_metadata_2025_split huggingface dataset:
Design and development of an economical temperature compensated bidirectional fiber Bragg grating flow sensor
Authors: Ullah Rahim , Khan Raja Yasir Mehmood , Faisal Muhammad 
Published: February 2023

Abstract
A target-type cantilever based temperature compensated fiber Bragg grating (FBG) flow sensor is designed and developed with economical demodulation and data acquisition schemes. FBG is glued on the surface of a thin elastic stainless steel cantilever in pre-strained condition. The cantilever is mounted inside a flow channel by a special purpose brass holder with a height and direction adjustable threaded stem. The sensor is interrogated by an optical spectrum analyzer (OSA) and indigenously developed twin FBGs and chirped FBG—FBG intensity demodulation schemes. Response of the sensor is investigated in the flow rate range of 0–10 l min−1 in both forward and reverse flow directions. In spectral demodulation, the flow sensor offered a linear response in the full investigated range with a sensitivity of 19.2 pm/(L/min). However, the twin FBGs demodulation scheme presented a linear behaviour in the range of 4–10 l min−1 with sensitivities of 1.22 ± 0.03 μW/(L/min) and 29.89 ± 0.55 mV/(L/min) detected by the high speed power meter and photodetector, respectively. The novel CFBG-FBG intensity demodulator offered a linear response throughout its tested range and can offer a flow rate detection up to 265 l min−1 at the present sensitivity of the sensor with the condition that the cantilever-FBG system must be strong enough to withstand the higher flow rates. The temperature of the fluid is monitored by an FBG temperature sensing probe connected to the flow channel using intensity demodulation scheme by another pair of twin FBGs. Temperature compensation of the flow sensor is performed by arithmetic operations over the reflection intensities due to temperature probe to the results of the flow rates using a cost-effective data acquisition scheme.
Experimental demonstration of a transient grating controlled all-optical switch
Authors: Akin Osman , Dinleyici Mehmet S 
Published: February 2023

Abstract
We demonstrate an on-fiber all-optical switching device based on a transient grating formed by the interference of control laser pulses in a Kerr-type nonlinear material placed in the evanescent region of the fiber. The device can operate in two distinctive modes. First, switching/coupling among the fiber modes using bulk index modulation was investigated and an efficiency of about %0.55 @852 nm was measured. Second, by exploiting Four Wave Mixing (FWM), an all-optical switching that transfers power among light signals with wavelengths of λ
1 = 440 nm and λ
2 = 663 nm was achieved by quasi-phase-matching and fRequency matching in a nonlinear thin polymeric film. The results prove that the introduced switching structure may have the potential to be used in integrated photonic applications such as intensity modulators or controllable couplers.
ARAX: a graph-based modular reasoning tool for translational biomedicine
Authors: Glen Amy K , Ma Chunyu , Mendoza Luis , Womack Finn , Wood E C , Sinha Meghamala , Acevedo Liliana , Kvarfordt Lindsey G , Peene Ross C , Liu Shaopeng , Hoffman Andrew S , Roach Jared C , Deutsch Eric W , Ramsey Stephen A , Koslicki David 
Published: February 2023

AbstractMotivationWith the rapidly growing volume of knowledge and data in biomedical databases, improved methods for knowledge-graph-based computational reasoning are needed in order to answer translational questions. Previous efforts to solve such challenging computational reasoning problems have contributed tools and approaches, but progress has been hindered by the lack of an expressive analysis workflow language for translational reasoning and by the lack of a reasoning engine—supporting that language—that federates semantically integrated knowledge-bases.ResultsWe introduce ARAX, a new reasoning system for translational biomedicine that provides a web browser user interface and an application programming interface (API). ARAX enables users to encode translational biomedical questions and to integrate knowledge across sources to answer the user’s query and facilitate exploration of results. For ARAX, we developed new approaches to query planning, knowledge-gathering, reasoning and result ranking and dynamically integrate knowledge providers for answering biomedical questions. To illustrate ARAX’s application and utility in specific disease contexts, we present several use-case examples.Availability and implementationThe source code and technical documentation for building the ARAX server-side software and its built-in knowledge database are freely available online (https://github.com/RTXteam/RTX). We provide a hosted ARAX service with a web browser interface at arax.rtx.ai and a web API endpoint at arax.rtx.ai/api/arax/v1.3/ui/.Supplementary informationSupplementary data are available at Bioinformatics online.
Medical school dermatology education: a scoping review
Authors: Mangion Sean E , Phan Tai A , Zagarella Samuel , Cook David , Ganda Kirtan , Maibach Howard I 
Published: February 2023

Abstract
Dermatological diseases are widespread and have a significant impact on the quality of life of patients; however, access to appropriate care is often limited. Improved early training during medical school represents a potential upstream solution. This scoping review explores dermatology education during medical school, with a focus on identifying the factors associated with optimizing the preparation of future physicians to provide care for patients with skin disease. A literature search was conducted using online databases (Embase, MEDLINE, CINAHL and Scopus) to identify relevant studies. The Joanna Briggs Institute methodological framework for scoping reviews was used, including quantitative and qualitative data analysis following a grounded theory approach. From 1490 articles identified, 376 articles were included. Most studies were from the USA (46.3%), UK (16.2%), Germany (6.4%) and Canada (5.6%). Only 46.8% were published as original articles, with a relatively large proportion either as letters (29.2%) or abstracts (12.2%). Literature was grouped into three themes: teaching content, delivery and assessment. Core learning objectives were country dependent; however, a common thread was the importance of skin cancer teaching and recognition that diversity and cultural competence need greater fostering. Various methods of delivery and assessment were identified, including computer-aided and online, audiovisual, clinical immersion, didactic, simulation and peer-led approaches. The advantages and disadvantages of each need to be weighed when deciding which is most appropriate for a given learning outcome. The broader teaching–learning ecosystem is influenced by (i) community health needs and medical school resources, and (ii) the student and their ability to learn and perform. Efforts to optimize dermatology education may use this review to further investigate and adapt teaching according to local needs and context.
Development and Validation of an On-Line HPLC-DAD-Antioxidant Assay (ORAC)/ESI-HRMS System to Identify Antioxidant Compounds in Complex Mixtures
Authors: Paillat Lionel , Bordier Eric , Guepet Alexandre , Lima Joaquim , Boudah Samia , Murtaugh Ashleigh 
Published: February 2023

AbstractAn online high-performance liquid-chromatography-diode-array detector coupled with detection of antioxidant compounds using oxygen radical absorbance capacity (ORAC) assay and electrospray ionization-high-resolution mass spectrometer (HPLC-DAD-antioxidant assay (ORAC)/ESI-HRMS) was developed for the identification of antioxidant compounds in complex mixtures. The method was validated using quercetin and a mixture of antioxidant compounds with different antioxidant activities (resveratrol, dihydroxymethoxy-dihydrochalcone, ferulic acid, baicalein and luteolin). Accuracy of the system was established by comparing the results from the developed system with those from ORAC microplate assay determination and reveals the ability of the system to determine the respective contribution of antioxidant compounds to the whole activity of complex mixtures. Application of the system to the identification of antioxidants in a commercial Yerba Mate extract (Ilex paraguariensis St. Hil.) reveals the occurrence of seven actives, which were characterized as chlorogenic acids isomers (3-O-caffeoylquinic acid, 4-O-caffeoylquinic acid and 5-O-caffeoylquinic acid), dicaffeoylquinic acid isomers (3,4-di-O-caffeoylquinic acid, 3,5-di-O-caffeoylquinic acid and 4,5-di-O-caffeoylquinic acid) and rutin based on UV/Vis spectra, HRMS and MS/MS data. This on-line system is able to generate HPLC-DAD fingerprints, UV/Vis spectra, ORAC activity profile and high-resolution mass spectrometric data.
Patterns of Infectious Disease Associated With Injection Drug Use in Massachusetts
Authors: Gonsalves Gregg S , Paltiel A David , Thornhill Thomas , DeMaria Alfred , Cranston Kevin , Klevens R Monina , Warren Joshua L 
Published: February 2023

Abstract

Background
Since 2014, multiple outbreaks of human immunodeficiency virus (HIV) among people who inject drugs have occurred across the United States along with hepatitis C virus (HCV), skin and soft tissue infections (SSTIs), and infective endocarditis (IE), creating a converging public health crisis.

Methods
We analyzed the temporal patterns of infectious disease and overdose using a hierarchical Bayesian distributed lag logistic regression model examining the probability that a given geographic area experienced at least 1 HIV case in a given month as a function of the counts/rates of overdose, HCV, SSTI, and IE and associated medical procedures at different lagged time periods.

Results
Current-month HIV is associated with increasing HCV cases, abscess incision and drainage, and SSTI cases, in distinct temporal patterns. For example, 1 additional HCV case occurring 5 and 7 months previously is associated with a 4% increase in the odds of observing at least 1 current-month HIV case in a given locale (odds ratios, 1.04 [90% credible interval {CrI}: 1.01–1.10] and 1.04 [90% CrI: 1.00–1.09]). No such associations were observed for echocardiograms, IE, or overdose.

Conclusions
Lagged associations in other infections preceding rises in current-month HIV counts cannot be described as predictive of HIV outbreaks but may point toward newly discovered epidemics of injection drug use and associated clinical sequalae, prompting clinicians to screen patients more carefully for substance use disorder and associated infections.
Stroke volume index and transvalvular flow rate trajectories in severe aortic stenosis treated with TAVR
Authors: Gallone Guglielmo , Islas Fabian , Gorla Riccardo , Melillo Francesco , Leone Pier Pasquale , Cimaglia Paolo , Pastore Maria Concetta , Franzone Anna , Landra Federico , Bruno Francesco , Scudeler Luca , Jimenez-Quevedo Pilar , Viva Tommaso , Piroli Francesco , Bragato Renato , Trichilo Michele , Degiovanni Anna , Ilardi Federica , Andreis Alessandro , Nombela-Franco Luis , Maurizio Tusa , Toselli Marco , Conrotto Federico , Montorfano Matteo , Manzo Rachele , Cameli Matteo , Patti Giuseppe , Stefanini Giulio , Testa Luca , Giannini Francesco , Agricola Eustachio , Escaned Javier , D’Ascenzo Fabrizio , De Ferrari Gaetano M 
Published: February 2023

Abstract

Aims
The prognostic impact of flow trajectories according to stroke volume index (SVi) and transvalvular flow rate (FR) in patients with severe aortic stenosis (AS) undergoing transcatheter aortic valve replacement (TAVR) remains poorly assessed. We evaluated and compared SVi and FR prior and after TAVR for severe AS.

Methods and results
Patients were categorized according to SVi (&lt;35 mL/m2) and FR (&lt;200 mL/s). The association of pre- and post-TAVR SVi and FR with all-cause mortality up to 3 years was assessed with multivariable Cox regression models. Among 980 patients with pre-TAVR flow assessment, SVi was reduced in 41.3% and FR in 48.1%. Baseline flow status was not an independent mortality predictor [SVi: hazard ratio (HR) 1.22, 95% confidence interval (CI) 0.85–1.82, FR: HR 0.78, 95% CI 0.48–1.27]. Among 731 patients undergoing early (5 days, interquartile range 2–29) post-TAVR flow assessment, SVi recovered in 40.1% and FR in 49.0% patients with baseline low flow. Reduced FR following TAVR was an independent predictor of mortality (HR 1.67, 95% CI 1.02–2.74), whereas SVi was not (HR 0.97, 95% CI 0.53–1.78). Three-year estimated mortality in patients with recovered FR was lower than that in patients with reduced FR (13.3 vs. 37.7% vs, P = 0.003) and similar to that in patients with normal baseline FR (P = 0.317).

Conclusion
Baseline flow status was not an independent predictor of mid-term mortality among all-comers with severe AS undergoing TAVR. Flow recovery early after TAVR was frequent. Post-TAVR FR, but not SVi, was independently associated with mid-term all-cause mortality. By impacting flow status, AV replacement modifies the association of flow status with outcomes.
Correlation between artificial intelligence-enabled electrocardiogram and echocardiographic features in aortic stenosis
Authors: Ito Saki , Cohen-Shelly Michal , Attia Zachi I , Lee Eunjung , Friedman Paul A , Nkomo Vuyisile T , Michelena Hector I , Noseworthy Peter A , Lopez-Jimenez Francisco , Oh Jae K 
Published: February 2023

Abstract

Aims
An artificial intelligence-enabled electrocardiogram (AI-ECG) is a promising tool to detect patients with aortic stenosis (AS) before developing symptoms. However, functional, structural, or haemodynamic components reflected in AI-ECG responsible for its detection are unknown.

Methods and results
The AI-ECG model that was developed at Mayo Clinic using a convolutional neural network to identify patients with moderate–severe AS was applied. In patients used as the testing group, the correlation between the AI-ECG probability of AS and echocardiographic parameters was investigated. This study included 102 926 patients (63.0 ± 16.3 years, 52% male), and 28 464 (27.7%) were identified as AS positive by AI-ECG. Older age, atrial fibrillation, hypertension, diabetes, coronary artery disease, and heart failure were more common in the positive AI-ECG group than in the negative group (P &lt; 0.001). The AI-ECG was correlated with aortic valve area (ρ = −0.48, R2 = 0.20), peak velocity (ρ = 0.22, R2 = 0.08), and mean pressure gradient (ρ = 0.35, R2 = 0.08). The AI-ECG also correlated with left ventricular (LV) mass index (ρ = 0.36, R2 = 0.13), E/e′ (ρ = 0.36, R2 = 0.12), and left atrium volume index (ρ = 0.42, R2 = 0.12). Neither LV ejection fraction nor stroke volume index had a significant correlation with the AI-ECG. Age correlated with the AI-ECG (ρ = 0.46, R2 = 0.22) and its correlation with echocardiography parameters was similar to that of the AI-ECG.

Conclusion
A combination of AS severity, diastolic dysfunction, and LV hypertrophy is reflected in the AI-ECG to detect AS. There seems to be a gradation of the cardiac anatomical/functional features in the model and its identification process of AS is multifactorial.
Long-term follow-up after simultaneous arterial switch operation and aortic arch repair
Authors: Kreuzer Michaela , Sames-Dolzer Eva , Tulzer Andreas , Gierlinger Gregor , Mair Roland , Nawrozi Mohammad-Paimann , Grangl Gernot , Mair Rudolf 
Published: February 2023

Abstract

OBJECTIVES
Taussig–Bing anomaly (TBA) and transposition of the great arteries (TGA) with hypoplastic or interrupted aortic arch (AA) are rare anomalies. Various operative techniques and a high incidence of reinterventions are described. The aim of this retrospective single-centre study was to evaluate operative data, mortality and reintervention rate with special regard to the AA.

METHODS
At the Children’s Heart Center Linz, 50 patients with the above-mentioned diagnosis have been corrected by a simultaneous repair between 2001 and 2022. Thirty-seven children had TBA, 13 had TGA and 5 of them had an interrupted AA. The median age at operation was 7 [interquartile range (IQR) 5–9] days, weight 3.38 (IQR 2.9–3.8) kg and follow-up 9.3 (IQR 3.1–14.5) years. The AA reconstruction was performed without patch material in 49 cases.

RESULTS
There was 1 in-hospital mortality in a TBA patient and 1 late mortality (7 years later, neuroblastoma). 14/49 patients needed at least 1 reoperation (28.6%, all TBA) and 3 further patients had catheter reintervention or radiofrequency ablation only (6.1%, 2 TBA). Seventy-five percent of these procedures affected the right heart/pulmonary arteries; there was 1 re-coarctation repair.

CONCLUSIONS
The simultaneous correction of TBA and TGA with AA obstruction or interruption is a safe operation with very low mortality. The AA reconstruction with minimized use of patch material resulted in a low restenosis rate.
Surgical outcome of ipsilateral anatomical resection for lung cancer after pulmonary lobectomy
Authors: Okazaki Mikio , Suzawa Ken , Shien Kazuhiko , Yamamoto Hiromasa , Araki Kota , Watanabe Mototsugu , Okada Masanori , Maki Yuho , Ueno Tsuyoshi , Otani Shinji , Sugimoto Ryujiro , Nishikawa Hitoshi , Okita Riki , Hayama Makio , Tao Hiroyuki , Fujiwara Toshiya , Inokawa Hidetoshi , Hirami Yuji , Sano Yoshifumi , Yamashita Motohiro , Kawamata Osamu , Matsuura Motoki , Toyooka Shinichi 
Published: February 2023

AbstractOBJECTIVESIpsilateral reoperation after pulmonary lobectomy is often challenging because of adhesions from the previous operation. We retrospectively examined the surgical outcome and prognosis of ipsilateral anatomical resection for lung cancer after pulmonary lobectomy using a multicentre database.METHODSWe evaluated the perioperative outcomes and overall survival of 51 patients who underwent pulmonary lobectomy followed by ipsilateral anatomical resection for lung cancer between January 2012 and December 2018. In addition, patients with stage I non-small-cell lung cancer (NSCLC) were compared with 3411 patients with stage I lung cancer who underwent pulmonary resection without a prior ipsilateral lobectomy.RESULTSIpsilateral anatomical resections included 10 completion pneumonectomies, 19 pulmonary lobectomies and 22 pulmonary segmentectomies. Operative time was 312.2 ± 134.5 min, and intraoperative bleeding was 522.2 ± 797.5 ml. Intraoperative and postoperative complications occurred in 9 and 15 patients, respectively. However, the 5-year overall survival rate after anatomical resection followed by ipsilateral lobectomy was 83.5%. Furthermore, in patients with c-stage I NSCLC, anatomical resection followed by ipsilateral lobectomy was not associated with worse survival than anatomical resection without prior ipsilateral lobectomy.CONCLUSIONSAnatomical resection following ipsilateral lobectomy is associated with a high frequency of intraoperative and postoperative complications. However, the 5-year overall survival in patients with c-stage I NSCLC who underwent ipsilateral anatomical resection after pulmonary lobectomy is comparable to that in patients who underwent anatomical resection without prior pulmonary lobectomy.
‘Life’s Essential 8’ cardiovascular health with premature cardiovascular disease and all-cause mortality in young adults: the Kailuan prospective cohort study
Authors: Xing Aijun , Tian Xue , Wang Yanxiu , Chen Shuohua , Xu Qin , Xia Xue , Zhang Yijun , Zhang Xiaoli , Wang Anxin , Wu Shouling 
Published: February 2023

Abstract

Aims
Whereas cardiovascular disease (CVD) metrics define risk in individuals aged over 40 years, the earliest lesions of CVD appear well before this age. Cardiovascular health (CVH) was proposed to improve cardiovascular risk factors and was updated recently. This study aimed to explore the associations of baseline and long-term CVH assessed by ‘Life’s Essential 8’ metrics with premature CVD and all-cause mortality in young Chinese adults.

Methods and results
A total of 16 011 CVD-free participants aged 18–40 years were enrolled from the Kailuan cohort study. The CVH score ranged from 0 to 100 and was categorized into low, moderate, and high. Cox regressions were used to assess the hazard ratios (HRs) for the associations of baseline, time-updated mean, and time-varying CVH with the risk of outcomes. During a median follow-up of 13 years, we identified 271 cases (1.7%) of CVD and 219 cases (1.4%) of all-cause mortality. A lower CVH was associated with a higher risk of CVD and all-cause mortality; the adjusted HR in the low CVH vs. the high CVH group was 7.34 [95% confidence interval (CI), 3.19–16.89] and 2.54 (95% CI, 1.27–5.06) for baseline CVH, 4.38 (95% CI, 2.14–8.97) and 1.99 (95% CI, 1.06–3.71) for time-updated CVH, and 8.19 (95% CI, 2.70–24.88) and 4.28 (95% CI, 1.70–10.81) for time-varying CVH, respectively.

Conclusion
We observed an inverse gradient association of baseline and long-term CVH with the risk of premature CVD and all-cause mortality in young adults, emphasizing the importance of keeping health behaviours and factors earlier in life.

Lay Summary
This longitudinal prospective cohort study showed an inverse gradient association of baseline and long-term cardiovascular health, as measured by the new updated Life’s Essential 8 metrics, with the risk of premature cardiovascular disease and all-cause mortality in Chinese young adults, emphasizing the importance of keeping health behaviours and factors earlier in life.Baseline and longitudinal low cardiovascular health (CVH) status (measured by time-updated mean and time-varying CVH score) was associated with a higher risk of cardiovascular disease (CVD) and all-cause mortality in young adults aged &lt;40 years.Among the eight metrics of LE8, lower scores of health factors were associated with a higher risk of CVD and all-cause mortality in young adults, while the associations of health behaviours with CVD and all-cause mortality were non-significant.
European Society of Cardiology quality indicators for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death
Authors: Aktaa Suleman , Tzeis Stylianos , Gale Chris P , Ackerman Michael J , Arbelo Elena , Behr Elijah R , Crotti Lia , d'Avila Andre , de Chillou Christian , Deneke Thomas , Figueiredo Márcio , Friede Tim , Leclercq Christophe , Merino Jose L , Semsarian Chris , Verstrael Axel , Zeppenfeld Katja , Tfelt-Hansen Jacob , Reichlin Tobias 
Published: February 2023

AbstractTo develop a suite of quality indicators (QIs) for the management of patients with ventricular arrhythmias (VA) and the prevention of sudden cardiac death (SCD). The Working Group comprised experts in heart rhythm management including Task Force members of the 2022 European Society of Cardiology (ESC) Clinical Practice Guidelines for the management of patients with VA and the prevention of SCD, members of the European Heart Rhythm Association, international experts, and a patient representative. We followed the ESC methodology for QI development, which involves (i) the identification of the key domains of care for the management of patients with VA and the prevention of SCD by constructing a conceptual framework of care, (ii) the development of candidate QIs by conducting a systematic review of the literature, (iii) the selection of the final set of QIs using a modified-Delphi method, and (iv) the evaluation of the feasibility of the developed QIs. We identified eight domains of care for the management of patients with VA and the prevention of SCD: (i) structural framework, (ii) screening and diagnosis, (iii) risk stratification, (iv) patient education and lifestyle modification, (v) pharmacological treatment, (vi) device therapy, (vii) catheter ablation, and (viii) outcomes, which included 17 main and 4 secondary QIs across these domains. Following a standardized methodology, we developed 21 QIs for the management of patients with VA and the prevention of SCD. The implementation of these QIs will improve the care and outcomes of patients with VA and contribute to the prevention of SCD.