bluuebunny/crossref_metadata_2025_split huggingface dataset:
The ‘small’ asteroid population: a spectroscopic survey
Authors: Michimani Jonatan , Rondón Eduardo , Perna Davide , Ieva Simone , Dotto Elisabetta , Mazzotta Epifani Elena , Barucci Antonella , Petropoulou Vasiliki , Lazzaro Daniela 
Published: September 2023

ABSTRACT
The study of near-Earth objects (NEOs) allow us to obtain information on the Solar system smallest bodies due to their closeness to Earth. In this work, we present the results of visible spectroscopic observations of 43 small and newly discovered NEOs, obtained during eighteen observing runs between October 2020 and December 2021, using the Goodman High Throughput Spectrograph at the 4.1-m Southern Astrophysical Research telescope (Cerro Pachón, Chile). We found a taxonomic distribution dominated by S-type asteroids but with an overabundance of A- and D-types. This result is in agreement with recent works on NEOs’ characterization and has implications for possible differences in the taxonomic distribution of ‘large’ and ‘small’ objects and emphasizes the idea of a non-homogeneous NEO population.
Reviving stochasticity: uncertainty in SMBH binary eccentricity is unavoidable
Authors: Rawlings Alexander , Mannerkoski Matias , Johansson Peter H , Naab Thorsten 
Published: September 2023

ABSTRACT
We study supermassive black hole (SMBH) binary eccentricity of equal-mass galaxy mergers in N-body simulations with the ketju code, which combines the gadget-4 fast multipole gravity solver with accurate regularized integration and post-Newtonian corrections around SMBHs. In simulations with realistic, high-eccentricity galactic merger orbits, the hard binary eccentricity is found to be a non-linear function of the deflection angle in the SMBH orbit during the final, nearly radial close encounter between the SMBHs before they form a bound binary. This mapping between the deflection angle and the binary eccentricity has no apparent resolution dependence in our simulations spanning the resolution range of 1 × 105 to 8 × 106 particles per galaxy. The mapping is also captured using a simple model with an analytical potential, indicating that it is driven by the interplay between a smooth asymmetric stellar background potential and dynamical friction acting on the SMBHs. Due to the non-linearity of this mapping, in eccentric major merger configurations, small, parsec-scale variations in the merger orbit can result in binary eccentricities varying in nearly the full possible range between e = 0 and e = 1. In idealized simulations, such variations are caused by finite resolution effects, and convergence of the binary eccentricity can be achieved with increasing resolution. However, in real galaxies, other mechanisms such as nuclear gas and substructure that perturb the merger orbit are likely to be significant enough for the binary eccentricity to be effectively random. Our results indicate that the distribution of these effectively random eccentricities can be studied using even moderate resolution simulations.
Void BAO measurements on quasars from eBOSS
Authors: Tamone Amélie , Zhao Cheng , Forero-Sánchez Daniel , Variu Andrei , Chuang Chia-Hsun , Kitaura Francisco-Shu , Kneib Jean-Paul , Tao Charling 
Published: September 2023

ABSTRACT
We present the clustering of voids based on the quasar (QSO) sample of the extended Baryon Oscillation Spectroscopic Survey Data Release 16 in configuration space. We define voids as overlapping empty circumspheres computed by Delaunay tetrahedra spanned by quartets of quasars, allowing for an estimate of the depth of underdense regions. To maximize the baryon acoustic oscillation (BAO) signal-to-noise ratio, we consider only voids with radii larger than 36h−1Mpc. Our analysis shows a negative BAO peak in the cross-correlation of QSOs and voids. The joint BAO measurement of the QSO autocorrelation and the corresponding cross-correlation with voids shows an improvement in 70 per cent of the QSO mocks with an average improvement of $\sim 5~{{\ \rm per\ cent}}$. However, on the SDSS data, we find no improvement compatible with cosmic variance. For both mocks and data, adding voids does not introduce any bias. We find under the flat ΛCDM assumption, a distance joint measurement on data at the effective redshift zeff = 1.51 of DV(zeff) = 26.558 ± 0.553. A forecast of a DESI-like survey with 1000 boxes with a similar effective volume recovers the same results as for light-cone mocks with an average of 4.8 per cent improvement in 68 per cent of the boxes.
A census of rotating radio transients at 150 MHz with the Irish LOFAR station
Authors: McKenna D J , Keane E F , Gallagher P T , McCauley J 
Published: September 2023

ABSTRACT
Rotating radio transients (RRATs) are neutron stars that emit detectable radio bursts sporadically. They are statistically distinct in the neutron star population, in many observable properties, but by their nature are practically difficult to study in depth. In this paper, we present the results from 1408 h of observations of RRAT candidates using the Irish station of the Low Frequency Array (LOFAR) at 150 MHz. As of October 2022, this census involved observing 113 sources, leading to 29 detections which were then followed up systematically. Single-pulse emission was detected from 25 sources, and periodic emission from 14 sources. Eighteen sources were found to have emission behaviour that is not discussed in prior works using LOFAR instruments. Four novel or modified source periods have been determined, ranging from 1.5 to 3.9 s, and eight new or updated phase-coherent pulsar timing ephemerides have been produced using detected bursts. One unexpected single-pulse with a clearly-Galactic dispersion measure was detected as a part of this work but has not been re-detected in follow-up observations. Observations are ongoing to expand the number of observed sources and further characterize and improve ephemerides for the detected sources. This census has demonstrated the capability for international LOFAR stations to detect, monitor, and characterize a significant fraction of these unique sources.
Telomeric i-motifs and C-strands inhibit parallel G-quadruplex extension by telomerase
Authors: El-Khoury Roberto , Roman Morgane , Assi Hala Abou , Moye Aaron L , Bryan Tracy M , Damha Masad J 
Published: September 2023

Abstract
Telomeric C-rich repeated DNA sequences fold into tetrahelical i-motif structures in vitro at acidic pH. While studies have suggested that i-motifs may form in cells, little is known about their potential role in human telomere biology. In this study, we explore the effect of telomeric C-strands and i-motifs on the ability of human telomerase to extend G-rich substrates. To promote i-motif formation at neutral pH, we use telomeric sequences where the cytidines have been substituted with 2′-fluoroarabinocytidine. Using FRET-based studies, we show that the stabilized i-motifs resist hybridization to concomitant parallel G-quadruplexes, implying that both structures could exist simultaneously at telomeric termini. Moreover, through telomerase activity assays, we show that both unstructured telomeric C-strands and telomeric i-motifs can inhibit the activity and processivity of telomerase extension of parallel G-quadruplexes and linear telomeric DNA. The data suggest at least three modes of inhibition by C-strands and i-motifs: direct hybridization to the substrate DNA, hybridization to nascent product DNA resulting in early telomerase dissociation, and interference with the unique mechanism of telomerase unwinding and extension of a G-quadruplex. Overall, this study highlights a potential inhibitory role for the telomeric C-strand in telomere maintenance.
Global profiling of ribosomal protein acetylation reveals essentiality of acetylation homeostasis in maintaining ribosome assembly and function
Authors: Ni Jinjing , Li Shuxian , Lai Yanan , Wang Zuoqiang , Wang Danni , Tan Yongcong , Fan Yongqiang , Lu Jie , Yao Yu-Feng 
Published: September 2023

Abstract
Acetylation is a global post-translational modification that regulates various cellular processes. Bacterial acetylomic studies have revealed extensive acetylation of ribosomal proteins. However, the role of acetylation in regulating ribosome function remains poorly understood. In this study, we systematically profiled ribosomal protein acetylation and identified a total of 289 acetylated lysine residues in 52 ribosomal proteins (r-proteins) from Salmonella Typhimurium. The majority of acetylated lysine residues of r-proteins were found to be regulated by both acetyltransferase Pat and metabolic intermediate acetyl phosphate. Our results show that acetylation plays a critical role in the assembly of the mature 70S ribosome complex by modulating r-proteins binding to rRNA. Moreover, appropriate acetylation is important for the interactions between elongation factors and polysomes, as well as regulating ribosome translation efficiency and fidelity. Dysregulation of acetylation could alter bacterial sensitivity to ribosome-targeting antibiotics. Collectively, our data suggest that the acetylation homeostasis of ribosomes is crucial for their assembly and function. Furthermore, this mechanism may represent a universal response to environmental signals across different cell types.
Coordination between aminoacylation and editing to protect against proteotoxicity
Authors: Zhang Hong , Murphy Parker , Yu Jason , Lee Sukyeong , Tsai Francis T F , van Hoof Ambro , Ling Jiqiang 
Published: September 2023

Abstract
Aminoacyl-tRNA synthetases (aaRSs) are essential enzymes that ligate amino acids to tRNAs, and often require editing to ensure accurate protein synthesis. Recessive mutations in aaRSs cause various neurological disorders in humans, yet the underlying mechanism remains poorly understood. Pathogenic aaRS mutations frequently cause protein destabilization and aminoacylation deficiency. In this study, we report that combined aminoacylation and editing defects cause severe proteotoxicity. We show that the ths1-C268A mutation in yeast threonyl-tRNA synthetase (ThrRS) abolishes editing and causes heat sensitivity. Surprisingly, experimental evolution of the mutant results in intragenic mutations that restore heat resistance but not editing. ths1-C268A destabilizes ThrRS and decreases overall Thr-tRNAThr synthesis, while the suppressor mutations in the evolved strains improve aminoacylation. We further show that deficiency in either ThrRS aminoacylation or editing is insufficient to cause heat sensitivity, and that ths1-C268A impairs ribosome-associated quality control. Our results suggest that aminoacylation deficiency predisposes cells to proteotoxic stress.
Specificity of cancer-related chromosomal translocations is linked to proximity after the DNA double-strand break and subsequent selection
Authors: Canoy Reynand Jay , Shmakova Anna , Karpukhina Anna , Lomov Nikolai , Tiukacheva Eugenia , Kozhevnikova Yana , André Franck , Germini Diego , Vassetzky Yegor 
Published: September 2023

Abstract
Most cancer-related chromosomal translocations appear to be cell type specific. It is currently unknown why different chromosomal translocations occur in different cells. This can be due to either the occurrence of particular translocations in specific cell types or adaptive survival advantage conferred by translocations only in specific cells. We experimentally addressed this question by double-strand break (DSB) induction at MYC, IGH, AML and ETO loci in the same cell to generate chromosomal translocations in different cell lineages. Our results show that any translocation can potentially arise in any cell type. We have analyzed different factors that could affect the frequency of the translocations, and only the spatial proximity between gene loci after the DSB induction correlated with the resulting translocation frequency, supporting the ‘breakage-first’ model. Furthermore, upon long-term culture of cells with the generated chromosomal translocations, only oncogenic MYC–IGH and AML–ETO translocations persisted over a 60-day period. Overall, the results suggest that chromosomal translocation can be generated after DSB induction in any type of cell, but whether the cell with the translocation would persist in a cell population depends on the cell type-specific selective survival advantage that the chromosomal translocation confers to the cell.
Shared decision making in elderly patients with kidney failure
Authors: Kanbay Mehmet , Basile Carlo , Battaglia Yuri , Mantovani Alessandro , Yavuz Furkan , Pizzarelli Francesco , Luyckx Valerie A , Covic Adrian , Liakopoulos Vassilios , Mitra Sandip 
Published: September 2023

ABSTRACT
‘Elderly’ is most commonly defined as an individual aged 65 years or older. However, this definition fails to account for the differences in genetics, lifestyle and overall health that contribute to significant heterogeneity among the elderly beyond chronological age. As the world population continues to age, the prevalence of chronic diseases, including chronic kidney disease (CKD), is increasing and CKD frequently progresses to kidney failure. Moreover, frailty represents a multidimensional clinical entity highly prevalent in this population, which needs to be adequately assessed to inform and support medical decisions. Selecting the optimal treatment pathway for the elderly and frail kidney failure population, be it haemodialysis, peritoneal dialysis or conservative kidney management, is complex because of the presence of comorbidities associated with low survival rates and impaired quality of life. Management of these patients should involve a multidisciplinary approach including doctors from various specialties, nurses, psychologists, dieticians and physiotherapists. Studies are mostly retrospective and observational, lacking adjustment for confounders or addressing selection and indication biases, making it difficult to use these data to guide treatment decisions. Throughout this review we discuss the difficulty of making a one-size-fits-all recommendation for the clinical needs of older patients with kidney failure. We advocate that a research agenda for optimization of the critical issues we present in this review be implemented. We recommend prospective studies that address these issues, and systematic reviews incorporating the complementary evidence of both observational and interventional studies. Furthermore, we strongly support a shared decision-making process matching evidence with patient preferences to ensure that individualized choices are made regarding dialysis vs conservative kidney management, dialysis modality and optimal vascular access.
Evaluation on the Sex-Specific Association Between Cigarette Smoke Exposure and Inflammation Markers—C-Reactive Protein and White Blood Cell Count
Authors: Koh Dong-Hee , Choi Sangjun , Park Ju-Hyun , Lee Sang-Gil , Kim Hwan-Cheol , Kim Inah , Park Dong-Uk 
Published: September 2023

Abstract

Introduction
Cigarette smoke increases peripheral white blood cell (WBC) count. However, the dose-dependent association between smoking and C-reactive protein (CRP), an important inflammatory marker, has been reported as inconsistent.

Aims and Methods
Here, we evaluated the associations between smoking and CRP using both smoking questionnaires and urine cotinine as exposure markers. The Korea National Health and Nutrition Examination Survey data were used for analyzing the associations. Multiple regression analyses were performed to examine the associations between cigarette smoke exposure, as assessed by questionnaires and urine cotinine, and health effects, as measured by CRP and WBC count, controlling for potential confounders. The confounders, including age, sex, body mass index, blood pressure, cholesterol, glucose, alanine aminotransferase, and uric acid, were selected a priori based on the literature.

Results
A total of 11 435 participants were included for analysis. For the exposure-response relationship, the results indicated a significant increase in CRP levels in male smokers compared to male nonsmokers (p = .002), whereas no significant increase was found in female smokers compared to female nonsmokers (p = .680). For the dose–response relationship, a significant positive association was observed between urine cotinine and CRP in male smokers (p = .018), whereas no significant association was found in female smokers (p = .508). WBC count consistently showed significant exposure-response and dose–response relationships in both sexes.

Conclusions
WBC count was found to be a consistent effect marker of cigarette smoke exposure, while the association between CRP level and smoking was inconsistent and varied by sex. The sex-specific response to cigarette smoke exposure warrants further exploration in future studies.

Implications
Cigarette smoke exposure is known to increase inflammation and has been thought to increase CRP, a significant inflammation marker. However, recent studies have reported conflicting results regarding the dose-dependent association between cigarette smoke exposure and CRP. This study found that the association between smoking and CRP is inconsistent and varies by sex, showing significant exposure response in men but not in women. Furthermore, the study suggests that WBC count is a more consistent marker for cigarette smoke exposure.
Exchange rates and binary political events
Authors: Venturi Pedro , Ferreira Alex , Gozluklu Arie , Gong Yujing 
Published: September 2023

Abstract
This article introduces a rational expectations model that explains exchange rate dynamics and the predictability of forecast errors using private (aggregated via order flow) and public (probabilities of a binary event) information. We test the model for the periods leading up to the presidential impeachment vote in Brazil, the Brexit Referendum, and Donald Trump’s election in 2016. Proxies of the physical probabilities of these events reveal that they are a crucial source of pricing information for the BRL, GBP, and MXN currency pairs with the US dollar. They also explain forecast errors. The information content of order flow changes before and after an actual regime change resolves uncertainty.
Beyond Institutional Adaptation: Legislative Europeanisation and Parliamentary Attention to the EU in the Hungarian Parliament
Authors: Bíró-Nagy András , Buzogány Aron 
Published: September 2023

Abstract
While studies of the formal adaptation of parliaments to the European Union (EU) have dominated legislative scholarship in the last two decades, there is a growing interest in the substantive impact of the EU on legislative production and parliamentary behaviour. We contribute to this research agenda by exploring the effects of Europeanisation on the national parliament of one democratically backsliding EU member state, Hungary. Comparing periods marked by Europhile and Eurosceptic parliamentary majorities between 2004 and 2018 shows that governmental attitudes towards the EU are not reflected in parliamentary law-making and that parliamentary attention is mainly influenced by the level of Europeanisation of the policy field. This shows that backsliding governments do not generally oppose greater integration and underscores the necessity to distinguish between rhetorical Euroscepticism and Eurosceptic legislative action.
From ACEs to early relational health: Implications for clinical practice
Authors: Williams Robin C 
Published: September 2023

Abstract
Children grow and develop in an environment of relationships. Safe, stable, nurturing relationships help build resilience and buffer the negative impact of adverse experiences. Promoting relational health in clinical practice shifts the focus from adverse childhood experiences (ACEs) to positive childhood experiences (PCEs). This approach evaluates a family’s strengths and assets, and can be incorporated into both well-child and subspecialty care. While the optimal window for such interventions is in the prenatal period or as early as possible within the first 3 years of life, it is never too late to start. This statement describes how clinicians can bring a relational health approach to any medical encounter by understanding: what toxic stress is and how it can affect the developing brain, family relationships, and child development; how positive relationships, experiences, and behaviours can help buffer such effects and build resilience; observable signs of relational health and risk in parent–child interactions; the attributes of trustful, therapeutic relationships with families; and how to optimize these benefits through conversation and clinical practice.
Big data policing: The use of big data and algorithms by the Netherlands Police
Authors: Schuilenburg Marc , Soudijn Melvin 
Published: September 2023

Abstract
In recent years, the rise of big data has revolutionized many domains, including policing. Research is lacking, however, on the various ways in which the police use big data applications. This study provides new insights into the ways the Netherlands Police currently use big data and algorithmic applications. Based on a novel data source—job vacancies in the IT domain for the Netherlands Police—we distinguish three areas in which big data is used: frontline policing, criminal investigations, and intelligence. Our research shows that the use of big data by the Netherlands Police mainly involves relatively simple applications and that—in contrast to police forces in the USA—big data applications with the objective of assessing risks are the least common. The research also shows that big data policing leads to greater discretionary powers for police functions such as software developers and network designers.
Circulating sex hormone-binding globulin levels and ischemic stroke risk: a Mendelian randomization study
Authors: Zeng Youjie , Cao Si , Yang Heng 
Published: September 2023

Abstract

Purpose
Previous studies have presented conflicting findings regarding the protective effects of circulating sex hormone-binding globulin (SHBG) on ischemic stroke (IS). This study aimed to assess the causal effect of SHBG on IS using Mendelian randomization (MR) analysis and to identify potential mediators.

Methods
First, the causal effect of SHBG on any IS (AIS), cardioembolic stroke (CES), large artery stroke (LAS), and small vessel stroke (SVS) was assessed by inverse variance weighed (IVW) method. Two additional MR methods (weighted median and MR-Egger) were used to supplement the IVW results. Subsequently, a two-step MR was further performed to assess whether three glycemic profiles [fasting glucose, fasting insulin, and glycated hemoglobin (HbA1c)] and five lipid profiles (high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, non-HDL cholesterol, total cholesterol, and triglycerides) mediated the causal effect. Furthermore, Cochrane’s Q test, MR-Egger intercept test, MR-PRESSO global test, and leave-one-out analysis were performed for sensitivity analyses.

Results
The IVW results showed that SHBG significantly reduced SVS risk (odds ratio= 0.60, 95% confidence interval: 0.47–0.77, P = 4.60E-05). The weighted median and MR-Egger results were parallel to IVW. However, no significant associations were found between SHBG and AIS, CES, and LAS. Mediation analysis indicated that HbA1c may be involved in SHBG reducing SVS risk. Sensitivity tests demonstrated the reliability of causal estimates.

Conclusions
Circulating SHBG levels may decrease SVS risk by lowering HbA1c levels. Therefore, individuals with low circulating SHBG levels should focus on glycemic control to reduce future SVS risk.