bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sugar‐Based Electroless Copper Deposition on Pectin‐Coated Alumina Microparticles
Authors: Mielewczyk Lukas , Liebscher Virginia , Grothe Julia , Kaskel Stefan 
Published: September 2023

AbstractA novel approach for fabricating copper‐coated alumina microparticles utilizing a pectin‐based coating subsequently followed by electroless deposition is reported. The biopolymer pectin is modified with phosphate groups covalently binding to the particle surface, while the polymer itself promotes the formation of metal centers on the surface due to the high affinity to metal cations. The sugar‐based (galactose, xylose, and glucose) electroless plating process in combination with an organic‐based treatment ensures a homogeneous metal coating method. As a benefit, precious metal activation of alumina particles and hazardous reducing agents typically employed are not required, creating a low‐cost and sustainable process. Metal plated micro particles show a uniform and homogeneous coating rendering them as ideal additives for application in metal matrix composites. These ceramic metal composites can be used in a wide range of applications where high‐strength metal components are needed.
Contact Electrification at Dielectric Polymer Interfaces: On Bond Scission, Material Transfer, and Electron Transfer
Authors: Verners Osvalds , Lapčinskis Linards , Sherrell Peter C. , Šutka Andris 
Published: September 2023

AbstractTriboelectric nanogenerators (TENGs) are revolutionizing mechanical‐to‐electrical energy harvesting. TENGs harvest energy through the polymer–polymer contact electrification (PCE) mechanism, driven by nanoscale processes at the contact interface. Currently, when discussing PCE there are two distinct schools of thought on which nanoscale interactions drive charging at the contact interface; 1) electron transfer, where orbital overlap leads to charge tunneling between polymers; or 2) mass (material) transfer, where polymer chain entanglement and intermolecular bonding leads to heterolytic bond scission. Here, a combination of in silico and benchtop experiments is used to elucidate the relative role of electron and mass transfer in PCE. In silico experiments show that covalent bond scission in a polymethylmethacrylate/polytetrafluoroethylene system occurs at 348 kcal mol−1, prior to electron cloud overlap, where the highest occupied molecular orbital and lowest unoccupied molecular orbital of the system remain separated by 163 kcal mol−1. Benchtop experiments show PCE‐generated charges cannot be simply discharged via electrical grounding, indicating the formation of bound surface charge from mass transfer. The calculations and contact‐electrification tests provide strong evidence to support mass transfer being the leading mechanism driving PCE.
3R Batteries: Resilient, Repairable, and Recyclable Based on Liquid Gallium Electrode
Authors: Parvini Elahe , Hajalilou Abdollah , Lopes Pedro Alhais , Silva André F. , Tiago Miguel Soares Maranha , Fernandes Pedro Miguel Patrício , de Almeida Anibal T. , Tavakoli Mahmoud 
Published: September 2023

AbstractBillions of disposable thin‐film electronics will be produced annually in the near future, for applications in smart packaging, IoT, and wearable biomonitoring patches. For these cases, traditional rigid batteries are not optimal neither in terms of form and ergonomics nor ecological aspects. There is an urgent need for a new class of energy storage devices that are thin, stretchable, resilient, and recyclable. Herein, a novel architecture of materials and fabrication techniques is presented that permit a fully 3D printed soft‐matter thin‐film battery that is Resilient to mechanical strain, Repairable if cut, Rechargeable, and Recyclable at the end of its life. By taking advantage of a digitally printable ultra‐stretchable liquid metal‐based current collector and a novel Gallium‐Carbon anode electrode, the Ag2O‐Gallium battery is rapidly printed and customized per application. By optimizing the properties of the Gallium‐Carbon composite, a record‐breaking areal capacity of 26.37 mAh cm−2 is obtained, which improves after 10 cycles at 100% strain to 30.32 mAh cm−2, and an unprecedented maximum strain tolerance of ≈200%. Partially damaged batteries heal themselves. Severely damaged batteries are healed through innovative cold‐vapor stimulation. An example of a digitally printed, taylor‐made battery‐on‐the‐board health‐monitoring patch with printed sensors for monitoring the heart, and respiration is demonstrated.
Regioselective Construction of Indolylated Cyclic Tetrasubstituted Carbon Centers through Brønsted Acid‐Catalyzed Dearomative Skeletal Rearrangement of Azofurans
Authors: Zhang Yin , Bao An‐Qi , Wu Ming , Rao Qian , Tu Man‐Su , Hao Wen‐Juan , Jiang Bo 
Published: September 2023

AbstractA Brønsted acid‐catalyzed dearomative skeletal rearrangement of azofurans with indoles is reported, enabling a regioselective 1,6‐addition, ring‐opening and 1,4‐addition cascade to produce 26 examples of indolylated pyrrol‐2‐ones with a cyclic tetrasubstituted stereocenter in 58–94% yields. This protocol demonstrates remarkable compatibility regarding azofurans and indoles with different substitution patterns, featuring complete regioselectivity.
Development Aramid Nanofiber‐ and Pentaerythritol‐Grafted Graphene Nanoplate‐Based High‐Performance Thermally Conductive Composites
Authors: Lee Wondu , Yang Wonyoung , Kim Jooheon 
Published: September 2023

AbstractA novel filler surface treatment is employed to produce thermally conductive composites using an aramid nanofiber (ANF) and pentaerythritol (PER) grafted onto the surface of graphite nanoplates (GnP). The resulting composite exhibits exceptional properties, including a high through‐plane thermal conductivity of 4 W mK−1, a high tensile strength of 163.58 MPa, and an improved flame retardancy. When the composite is applicated in central processing unit (CPU), the efficient thermal management performance is achieved with a decreased operating temperature of 12 °C. The ANF/GnP–PERANF composites are promising for enhancing thermal management in electric devices. The manufactured ANF composites will open new avenues for advancing the development of next‐generation thermal management systems.
Risk of cognitive decline progression is associated to increased blood‐brain‐barrier permeability: A longitudinal study in a memory unit clinical cohort
Authors: Puig‐Pijoan Albert , Jimenez‐Balado Joan , Fernández‐Lebrero Aida , García‐Escobar Greta , Navalpotro‐Gómez Irene , Contador Jose , Manero‐Borràs Rosa‐María , Puente‐Periz Victor , Suárez Antoni , Muñoz Francisco J. , Grau‐Rivera Oriol , Suárez‐Calvet Marc , de la Torre Rafael , Roquer Jaume , Ois Angel 
Published: September 2023

AbstractINTRODUCTIONThis study examined the relationship between blood‐brain‐barrier permeability (BBBp), measured by cerebrospinal fluid/serum albumin ratio (QAlb), and cognitive decline progression in a clinical cohort.METHODSThis prospective observational study included 334 participants from the BIODEGMAR cohort. Cognitive decline progression was defined as an increase in Global Deterioration Scale and/or Clinical Dementia Rating scores. Associations between BBBp, demographics, and clinical factors were explored.RESULTSMale sex, diabetes mellitus, and cerebrovascular burden were associated with increased log‐QAlb. Vascular cognitive impairment patients had the highest log‐QAlb levels. Among the 273 participants with valid follow‐up data, 154 (56.4%) showed cognitive decline progression. An 8% increase in the hazard of clinical worsening was observed for each 10% increase in log‐QAlb.DISCUSSIONThese results suggest that increased BBBp in individuals with cognitive decline may contribute to clinical worsening, pointing to potential targeted therapies. QAlb could be a useful biomarker for identifying patients with a worse prognosis.
Hypercoordination by Multiple Dangling Benzylmethoxy Ligands in Highly Crowded Triaryltin Bromide [(2‐MeOCH2C6H4)]3SnBr and Diaryltin Mixed Halides [(2‐MeOCH2C6H4)]2SnBrCl, and a related Distannane and Distannoxane
Authors: van den Bogaard Henk S. , Sharma Hemant K. , Mettta‐Magaña Alejandro , Pannell Keith H. 
Published: September 2023

AbstractThe reaction between the Grignard reagent formed from Mg and 2‐bromobenzylmethyl ether and SnCl4 produced four products: [2‐(MeOCH2)C6H4]3SnBr (1), [2‐(MeOCH2)C6H4]2SnX2 (2, X2=Br2 (a) and BrCl (b)), [{2‐(MeOCH2)C6H4}3Sn]2 (3), and [{2‐(MeOCH2)C6H4}2SnBr]2O (4). In the case of 1, two of the three dangling arm O atoms coordinate to the central tin atom with O−Sn internuclear distances of 2.53 (O1) and 2.91 (O2) Å, the shorter interaction being trans to the Br atom, the other trans to a phenyl carbon atom. In the case of 2a the resulting hexacoordinate structure exhibits two very short O−Sn interactions of 2.42 and 2.50 Å, well below the sum of the VdW radii of O and Sn, 3.69 Å. The sterically crowded ditin compound 3 was obtained in trace amounts and the structure demonstrates no dangling O−Sn interactions. General changes in structure compared to other distannane systems are reflective of the great steric crowding. Distannoxane 4, has a Sn−O−Sn bond angle of 148.1(2)° which is larger compared to other distannoxane structures. The intermolecular interactions between Sn−O 2.470(3) and 2.521(3)Å and 2.665(3) and 2.629(3)Å for Sn1 and Sn2 respectively are responsible for a distorted octahedral geometry around the two tin atoms. The various 119Sn, 13C and 1H NMR spectra are in accord with their structural analysis for 1 and 2, and in the solid state 13C NMR spectrum of 1 the dangling methylene group is observable whereas is solution there is a rapid dynamic equilibrium resulting in a single resonance for all methylene groups.
Paternal age and risk for selected birth defects in a large South American sample
Authors: Gili Juan A. , Rittler Monica , Heisecke Silvina , Campaña Hebe , Giménez Lucas , Santos María Rita , Ratowiecki Julia , Cosentino Viviana , López Camelo Jorge , Poletta Fernando A. 
Published: September 2023

AbstractBackgroundThe relationship between maternal age (MA) and birth defects (BD) has been extensively studied while much less research, mostly with discordant results, has focused on the risk of paternal age (PA) for BD. Furthermore, no consensus has been reached on the best way to control the association of PA with MA.ObjectivesThe aim of the study was to evaluate the risk of PA increase, at 1‐year intervals, for selected BD, especially controlling for the confounding effect of MA.MethodsThe sample comprised of 27,944 liveborns presenting 1 of 18 selected isolated BD. Conditional logistic regressions were applied to evaluate the risk of advanced PA and its yearly increase, adjusting by MA and other variables.ResultsOf the 18 analyzed BD, only the risk for preaxial polydactyly (PreP) showed a significant association with increasing PA, while advanced MA was of low risk. For esophageal and anal atresia, associations with both PA and MA increases were observed.ConclusionsResults support the hypothesis of advanced PA as a risk factor for PreP and helps clarify the so far unexplained nonrandom association between this defect and Down syndrome.
Exploring how consumer cooperatives might strategically incorporate social media to distribute wine
Authors: Pelet Jean‐Éric , Taieb Basma , Lecat Benoît , Terblanche Nic S. , Alkhudary Rami 
Published: September 2023

AbstractThis research advances our understanding of disruptions to marketing channels in the digital world by investigating the viability of consumer cooperative systems which are envisioned as multi‐actor constructed networks using social media (SM) platforms. It introduces the concepts of “social media consumer wine cooperator” as a new distribution channel for wine and investigates the consumer's intention to participate in an SM and become a wine cooperator. Relying on the uses and gratifications theory (UGT), we adopted a quantitative research inquiry with data gathered using an online survey involving a sample of 486 French consumers. We empirically tested the relationships among four factors: attitude toward buying wine based on SM recommendations, perceived risks, intention to buy wine on SM, and consumer intention to become an SM wine cooperator. Findings indicate that the intention to be an SM wine cooperator is positively correlated with attitude toward buying wine based on SM recommendations and the intention to purchase wine on SM. To finish with, we link the concept of the consumer wine co‐op to the current debate in the literature on centralized versus decentralized (built on top of blockchain networks) social media platforms, opening the door for future research avenues.
Use of ropeginterferon in inducing graft versus myelofibrosis effect in post‐transplant myelofibrosis relapse
Authors: Srivastava Barnali , Wolschke Christine , Gagelmann Nico , Badbaran Anita , Kröger Nicolaus 
Published: September 2023

Key Clinical MessageHere, we describe a patient with post‐transplant myelofibrosis with chronic graft‐versus‐host disease (GVHD), who showed successful molecular remission with ropeginterferon with 100% donor chimerism without any flare up of GVHD. He was initially diagnosed with polycythemia vera (PV) which progressed to myelofibrosis after 6 years. The MYSEC (Myelofibrosis Secondary to PV and ET‐Prognostic Model) and MTSS (myelofibrosis transplant scoring system) scores were 13.1 and 4, respectively, and the patient was in intermediate risk group. He underwent an allogenic stem cell transplant; however, his disease gradually progressed and was administered two donor lymphocyte infusions with minimal response. A second allogeneic transplant was performed, which led to a persistent molecular remission for more than a decade, although he developed chronic skin graft‐versus‐host disease (GVHD). The JAK2 V617F levels started to increase 10 years post‐transplant with ongoing chronic GVHD and a corresponding decrease in donor chimerism levels. He was administered ropeginterferon, which led to a decrease in JAK 2617F to undetectable levels. A graft versus myelofibrosis effect was attained with reversal to 100% donor chimerism, and he has since maintained a molecular remission with undetectable JAK 2617F levels. Chronic GVHD made him ineligible for donor lymphocyte infusions later. Thus, ropeginterferon was successful in inducing graft versus myelofibrosis effect, leading to a molecular response with no flare up of GVHD. The use of ropeginterferon needs to be further evaluated in larger cohorts of post‐transplant myelofibrosis patients.
Green synthesis of (S)‐1‐(furan‐2‐yl)propan‐1‐ol from asymmetric bioreduction of 1‐(furan‐2‐yl)propan‐1‐one using whole‐cell of Lactobacillus paracasei BD101
Authors: Bülbül Ali Savaş , Şahin Engin 
Published: September 2023

AbstractChiral heterocyclic alcohols are important precursors for production of pharmaceutical medicines and natural products. (S)‐1‐(furan‐2‐yl)propan‐1‐ol ((S)‐2) can be used production of pyranone, which can be used in the synthesis of sugar analogues, antibiotics, tirantamycines, and anticancer drugs. The synthetic approaches for (S)‐2, however, have substantial difficulties in terms of inadequate enantiomeric excess (ee) and gram scale synthesis. Moreover, the biocatalytic synthesis of (S)‐2 is unknown until now. In this study, the synthesis of (S)‐2 was carried out by performing the asymmetric bioreduction of 1‐(furan‐2‐yl)propan‐1‐one (1) using the Lactobacillus paracasei BD101 biocatalyst obtained from boza, a grain‐based fermented beverage. (S)‐2 was obtained with >99% conversion, >99% ee, and 96% yield under the optimized conditions. Furthermore, in 50 h, 8.37 g of 1 was entirely transformed into (S)‐2 on gram scale (96% isolated yield, 8.11 g). This is the first report on the high‐gram scale biocatalyzed synthesis of enantiopure (S)‐2. These data suggest that L. paracasei BD101 can be used to bioreduction of 1 in gram scale and efficiently produce (S)‐2. Furthermore, these findings laid the base for future study into the biocatalytic production of (S)‐2. It was particularly notable as it was the highest known to date optical purity of (S)‐2 generated by asymmetric reduction using a biocatalyst. This work offers a productive environmentally friendly method for producing (S)‐2 using biocatalysts.
Metal Recycling via Biohydrometallurgy
Authors: Hedrich Sabrina , Fritze Mareike , Schippers Axel 
Published: September 2023

AbstractDie Biohydrometallurgie als Teilgebiet der Hydrometallurgie macht sich spezielle Stoffwechselleistungen von Mikroorganismen zur Metallgewinnung zu nutze. Biomining ist die angewandte Biolaugung zur Metallgewinnung aus sulfidischen Erzen. Für das Recycling, also die Metallgewinnung aus Abfall und Reststoffen, gibt es bisher noch keine angewandten biohydrometallurgischen Verfahren, aber vielversprechende Laborversuche zur Metallextraktion aus Feststoffen. In diesem Übersichtsartikel werden diese zusammenfassend dargestellt und Perspektiven aufgezeigt.
Extractive denitrogenization of liquid model fuel using polyethylene glycol methyl ether 350
Authors: Solov'ev Vitaliy O. , Solov'eva Svetlana V. , Zakhodyaeva Yulia A. , Voshkin Andrey A. 
Published: September 2023

AbstractIn the present study, we studied the effectiveness of the water‐soluble polymer polyethylene glycol methyl ether 350 (PEG ME‐350) on the extraction of nitrogen‐containing heterocyclic compounds—quinoline and indole—from n‐hexane. The dependences of the quantitative characteristics of the extraction of N‐compounds on the contact time of the phases, the content of PEG ME‐350 in the n‐hexane–water system, the initial concentration of nitrogen‐containing heterocyclic compounds in the organic phase, and the volumetric ratio of the phases were obtained. It has been established that PEG ME‐350 is an effective extractant in the process of stepwise extraction of quinoline and indole, and the mechanisms of their extraction have also been proposed and proven. The results can be further used in the purification of light hydrocarbon fractions from nitrogen‐containing heterocyclic compounds.
Cancer hygiene hypothesis: A test from wild captive mammals
Authors: Dujon Antoine M. , Jeanjean Jérémy , Vincze Orsolya , Giraudeau Mathieu , Lemaître Jean‐François , Pujol Pascal , Ujvari Beata , Thomas Frédéric 
Published: September 2023

AbstractThe hygiene hypothesis, according to which the recent reduction of exposure to infectious agents in the human species would be the origin of various diseases, including autoimmune diseases and cancer, has often been proposed but not properly tested on animals. Here, we evaluated the relevance of this hypothesis to cancer risk in mammals in an original way, namely by using information on zoo mammals. We predicted that a higher richness of parasitic cohorts in the species' natural habitat would result in a greater occurrence of evolutionary mismatch due to the reduction of parasites in captive conditions. This, in turn, could contribute to an increased risk of developing lethal cancers. Using a comparative analysis of 112 mammalian species, we explored the potential relationship between cancer risk and parasite species richness using generalized phylogenetic least squares regressions to relate parasite species richness to cancer risk data. We found no strong evidence that parasite species richness increased cancer risk in zoo mammals for any of the parasite groups we tested. Without constituting definitive proof of the irrelevance of the hygienic hypothesis, our comparative study using zoo mammals does not support it, at least with respect to cancer risks.
Geographic, sex and socioeconomic disparities in esophageal cancer incidence in China: A population‐based study
Authors: Ran Xianhui , Zeng Hongmei , Zheng Rongshou , Sun Kexin , Han Bingfeng , Wang Shaoming , Chen Ru , Li Li , Wei Wenqiang , He Jie 
Published: September 2023

AbstractGeographic and sex differences in esophageal cancer have been reported in China, but data are lacking at the local level. We aimed to investigate geographic and sex disparities in esophageal cancer incidence among Chinese counties and whether county‐level socioeconomic status was associated with these variations. We obtained esophageal cancer data from 2015 to 2017 for 782 counties from population‐based cancer registries in China. We calculated age‐standardized incidence rates and male‐to‐female incidence rate ratios (IRRs) by county. We performed hotspot analysis to identify geographical clusters. We used negative binomial regression models to analyze the association between incidence rates and county‐level socioeconomic factors. There were significant geographic disparities in esophageal cancer incidence, with 8.1 times higher rate in the 90th‐percentile county than in the 10th‐percentile county (23.7 vs 2.9 per 100 000 person‐years). Clusters of elevated rates were prominent across north‐central China. Nationally, men had 2.9 times higher incidence of esophageal cancer than women. By county, the male‐to‐female IRRs ranged from 1.1 to 21.1. Clusters of high male‐to‐female IRRs were observed in northeast China. Rurality (IRR 1.16, 95% CI 1.10‐1.22), per capita gross domestic product (IRR 0.95, 0.92‐0.98) and percentage of people with a high school diploma (IRR 0.86, 0.84‐0.87) in a county were significantly associated with esophageal cancer incidence. The male‐to‐female IRRs were higher in counties with higher socioeconomic status. Substantial differences in incidence rates and sex ratios of esophageal cancer exist between Chinese counties, and county‐level socioeconomic status was associated with these variations. These findings may inform interventions to reduce these disparities.
Spinster homolog 2 reduces malignancies of glioblastoma via PTEN/PI3K/AKT pathway
Authors: Liang Weiye , Liu Mingkai , Su Yuling , Wen Yulin , Wang Lili , Shan Jiajie , Zhao Jie , Xie Keping , Wang Jian 
Published: September 2023

AbstractThe molecular mechanisms of glioblastoma (GBM) are unclear, and the prognosis is poor. Spinster homolog 2 (SPNS2) is reportedly involved in pathological processes such as immune response, vascular development, and cancer. However, the biological function and molecular role of SPNS2 in GBM are unclear. SPNS2 is aberrantly low expressed in glioma. Survival curves, risk scores, prognostic nomograms, and univariate and multifactorial Cox regression analyses showed that SPNS2 is an independent prognostic indicator significantly associated with glioma progression and prognosis. Cell function assays and in vivo xenograft transplantation were performed that downregulation of SPNS2 promoted GBM cell growth, migration, invasion, epithelial–mesenchymal transition (EMT), anti‐apoptosis, drug resistance, and stemness, while overexpression of SPNS2 had the opposite effect. Meanwhile, the functional enrichment and signaling pathways of SPNS2 in the Cancer Genome Atlas (TCGA), Chinese Glioma Genome Atlas (CGGA), and RNA sequencing were analyzed by Gene ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), and Gene set enrichment analysis (GSEA). The above results were related to the inhibition of the PTEN/PI3K/AKT pathway by SPNS2. In addition, we predicted that SPNS2 is closely associated with immune infiltration in the tumor microenvironment by four immune algorithms, ESTIMATE, TIMER, CIBERSORT, and QUANTISEQ. In particular, SPNS2 was negatively correlated with the infiltration of most immune cells, immunomodulators, and chemokines. Finally, single‐cell sequencing analysis also revealed that SPNS2 was remarkably correlated with macrophages, and downregulation of SPNS2 promotes the expression of M2‐like macrophages. This study provides new evidence that SPNS2 inhibits malignant progression, stemness, and immune infiltration of GBM cells through PTEN/PI3K/AKT pathway. SPNS2 may become a new diagnostic indicator and potential immunotherapeutic target for glioma.