bluuebunny/crossref_metadata_2025_split huggingface dataset:
Is lipedema a progressive disease?
Authors: Forner-Cordero Isabel , Muñoz-Langa José 
Published: January 2025

Background: It is not yet known whether lipedema is a progressive chronic disease or not. The aim of this paper is to describe the long-term changes in the volume of the lower limbs. Methods: The primary endpoint of this prospective cohort study of patients with lipedema was the percentage of volume change (PVC) during follow up. Progression was defined as when the PVC was > 10% from the baseline, whereas improvement was defined as when the PVC was < –10%, and stability as PVC −10% to 10%. Results: A cohort of 100 patients with lipedema were included in the study. The average follow-up period from the start of this study was 4.6 years. The average PVC was 2.8%. Stability was observed in 62% of the patients, progression in 28%, and improvement in 10%. In the univariate analysis, a significant positive association was observed between PVC and both BMI-change and waist-to-height ratio (WHtR)-change. The more the BMI increased, the more the lipedema progressed ( p < 0.0001), as did the WHtR ( p < 0.0001). In the adjusted regression analysis, age was not seen to be an influencing factor for PVC. Regarding maintenance therapies, no associations were observed. Conclusion: Lipedema was seen to be stable in two-thirds of the patients. Age was not related to progression. Progression was related to WHtR increase, which is an indicator of abdominal fat gain. This demonstrates the relationship between fat gain and lipedema progression.
Potential role of formononetin as a novel natural agent in Alzheimer's disease and osteoporosis comorbidity
Authors: Wang Zhigang , Liang Qiaoyi , Lin Zhaoqiu , Li Hongyang , Chen Xin , Zou Zhenyou , Mo Jingxin 
Published: January 2025

Background The growing aging population has led to an increase in the prevalence of Alzheimer's disease (AD) and osteoporosis (OP), both of which significantly impair quality of life. The comorbid nature of these conditions suggests a shared genetic etiology, the understanding of which is crucial for developing targeted therapies. Objective This study aims to explore the shared genetic etiology underlying AD and OP, using a system biology approach to identify potential therapeutic targets and natural compounds for treatment. Methods We employed Weighted Gene Co-Expression Network Analysis (WGCNA) with molecular docking strategies to uncover the genetic links between AD and OP. MT2A and CACNA1C were identified as key pleiotropic hub genes potentially linking AD and OP. Molecular docking was utilized to screen for compounds with therapeutic potential, leading to the identification of formononetin as a compound with significant binding affinity to these hub genes. Quantitative real-time PCR (qRT-PCR) validation was conducted to confirm the gene expression changes in disease models. Results Our study indicate that formononetin exhibits strong binding affinity to the identified hub genes, MT2A and CACNA1C. qRT-PCR validation confirmed the upregulation of these genes in disease models, which was mitigated upon treatment with formononetin, suggesting a reversal of disease markers. Conclusions This study advances our understanding of the genetic intersections between AD and OP and positions formononetin as a promising natural agent for further translational research. Formononetin's multi-target potential makes it a valuable candidate for managing these comorbid conditions, meriting further investigation and development as a therapeutic strategy.
Optokinetic After-Nystagmus: A Marker for Migraine? A Prospective Observational Study
Authors: Kassin-Dufresne Mikaël , Charest Bossé Marie-Catherine , Aron Margaret 
Published: January 2025

Introduction Vestibular migraine (VM), particularly its chronic variant, poses a diagnostic challenge. Patients suffering from VM may not have the characteristic headaches associated with the dizziness. In these cases, a marker for migraine pathology in general could help appropriately diagnose certain types of dizziness as migrainous despite these patients not meeting current diagnostic criteria for VM. Migraine patients in general (headache and vestibular) are known to share a tendency toward intolerance of certain stimuli, including busy visual stimuli. True optokinetic stimulation, measured by the production of optokinetic after-nystagmus (OKAN) simulates these busy visual stimuli. Methods Prospective observational study comparing response to optokinetic stimulation between migraine patients and controls. Questionnaires regarding general sensitivities to busy visual stimuli were completed prior to beginning the study. Both subjective and objective markers of stress were measured before and after exposure to the stimulus. Initial slow-phase velocity, slow cumulative eye position, and adjusted time constant of OKAN were compared between the 2 groups. Results The groups differed only with regard to sensitivity to blinking lights and history of motion sickness on initial questionnaire. Regarding subjective symptoms of discomfort, migraine patients tended to report higher scores than controls both before and after testing, but there was no significant difference from before to after stimulus in each group’s scores. There were no statistically-significant differences between initial slow-phase velocity, slow cumulative eye position, and adjusted time constant of OKAN between groups. Conclusions In this study, OKAN measurements were not useful in differentiating migraine patients at large from control subjects. We hypothesize that there may be a distinct subgroup of migraine patients that are more sensitive to visually-disturbing situations that may differ from other migraine sufferers. Future studies will aim to identify such patients and compare them to controls.
Clinical Outcomes of Isolated ACL Reconstruction Versus Combined ACL and ALL Reconstruction With Indication Guided by Intraoperative Ultrasound: A Propensity Score–Matched Study of 260 Patients With a Minimum 2-Year Follow-up
Authors: Ripoll Thomas , Vieira Thais Dutra , Saoudi Samy , Marris Victor , Nicolle Romain , Noguero Antoine , Marot Vincent , Berard Emilie , Cavaignac Etienne 
Published: January 2025

Background: Additional anterolateral ligament (ALL) reconstruction has been associated with improved clinical outcomes and reduced failure rates in anterior cruciate ligament (ACL) reconstruction. Despite the excellent clinical results reported, there is still a heated debate about its indications. Currently, the indications are mainly based on the patient’s clinical criteria and not the imaging diagnosis of the injury of this ligament. Purpose: To compare the clinical outcomes of patients undergoing isolated ACL reconstruction and combined ACL and ALL reconstruction conditioned to intraoperative ultrasound-guided diagnosis of the ALL lesion. Study design: Cohort study; Level of evidence, 3. Methods: A retrospective analysis of prospectively collected data was performed. Patients undergoing primary ACL reconstruction between January 2017 and January 2022 were included. Patients were excluded if they had a previous history of ipsilateral knee surgery or if they underwent other concomitant procedures, including multiligament reconstruction surgery or osteotomy. The decision to perform an ALL reconstruction in addition to isolated ACL reconstruction was based on ultrasound diagnosis of this lesion. At the end of the study period, further knee injury and any other reoperations or complications were recorded and compared between patients who had isolated ACL reconstruction (no-ALLR group) and combined ACL and ALL. Propensity score matching was performed between groups. A multivariable analysis using the penalized Cox model was performed to explore the relationship between the graft rupture, surgical procedure type, and potential explanatory variables. Results: A total of 339 patients met the predefined eligibility criteria; 146 ACL reconstructions were performed in an isolated manner (no-ALLR group) and 193 were combined with ALL (ALLR group). After matching, 130 patients were allocated to each group. The mean follow-up was 36.7 months. The overall graft failure rate was 4.6% (6.9% in the no-ALLR group and 2.3% in the ALLR group; P = .076). The adjusted Cox regression showed that graft failure rate was nonsignificantly different between the groups (adjusted hazard ratio [HR], 0.36 [95% CI, 0.096-1.364]; P = .133). Younger age (≤20 years) was associated with graft failure (adjusted HR, 0.29 [95% CI, 0.121-0.719]; P = .007). Conclusion: Combined ACL and ALL reconstruction conditioned to intraoperative ultrasound-guided diagnosis of the ALL lesion has an equivalent ACL graft failure rate to isolated ACL. Intraoperative ultrasound diagnosis of an ALL injury may be an indication for the addition of an ALL reconstruction.
Functional Recovery and Clinical Outcome After Internal Fixation Using Osteochondral Autologous Transplantation for Osteochondritis Dissecans of the Knee
Authors: Amai Kenta , Kanto Ryo , Onishi Shintaro , Nakayama Hiroshi , Yoshiya Shinichi , Tachibana Toshiya , Iseki Tomoya 
Published: January 2025

Background: Functional recovery and return to sports after fixation of osteochondritis dissecans (OCD) lesions of the knee with osteochondral autologous transplantation (OAT) have not been well investigated. Purpose: To retrospectively evaluate the functional recovery and clinical outcomes after internal fixation with OAT for knee OCD. Study Design: Case series; Level of evidence, 4. Methods: A consecutive series of patients who underwent OAT for OCD lesions between 2010 and 2020 were initially enrolled in the study. Patients with adult-onset OCD and those who underwent fragment removal and/or mosaicplasty were excluded. Lysholm score, Tegner activity scale, return-to-sports rate (at the practice/training and preinjury levels), and time to return were evaluated. Clinical factors influencing postoperative functional recovery were analyzed. Results: Included were 24 patients (26 knees); there were 23 male and 1 female patients, with a mean age of 14.7 years. The mean follow-up period was 27.6 months. A total of 17 lesions were located in the medial femoral condyle and 9 in the lateral femoral condyle. The mean Tegner score was 7.0 preoperatively and 6.5 postoperatively, with no significant difference. The return-to-sports rate was 96.2% at the practice/training level and 84.6% at the preinjury level, with an average return time of 5.1 months and 9.6 months, respectively. In a subgroup analysis of knees that returned to preinjury level ( n = 22) by lesion location, there was a significant difference between knees with lesions in the lateral femoral condyle (12.9 months) versus the medial femoral condyle (8.1 months) ( P = .02). The rate of return to preinjury level after primary surgery was significantly higher than after revision surgery after failed drilling ( P = .02). Conclusion: Return-to-sports rates and clinical outcomes were favorable after fixation with OAT in patients with knee OCD. A shorter time to return to sports was observed in knees with medial lesions compared with lateral lesions. Furthermore, the rate of return to sports at the preinjury level was significantly higher after primary surgery than after revision surgery after drilling.
Comparison of Dynamic Postural Stability in Autografts Versus Allografts Following Anterior Cruciate Ligament Reconstruction With Remnant Preservation: A Prospective Study With 1-Year Follow-up
Authors: Rhim Hye Chang , Lee Jin Hyuck , Lee Seo Jun , Kang Chun Hyung , Han Seung-Beom , Jang Ki-Mo 
Published: January 2025

Background: Graft selection is an important part of preoperative planning for anterior cruciate ligament reconstruction (ACLR). In addition, ACLR with the remnant preservation technique has recently gained attention due to potential benefit in bone-tendon healing, graft revascularization, and proprioceptive nerve remodeling. However, the ideal graft choice remains controversial, and there is limited research comparing autograft and allograft in ACLR with remnant preservation. Purpose: To compare knee muscle strength, neuromuscular control, and patient-reported outcomes between hamstring (HS) tendon autografts and tibialis anterior (TA) allografts in patients undergoing ACLR with remnant preservation through posterior transseptal portal for >1 year. Study Design: Cohort study; Level of evidence, 3. Methods: A total of 70 patients who underwent ACLR with remnant preservation between 2018 and 2021 using HS tendon autograft (n = 35) or TA allograft (n = 35) were analyzed at 3 different time points (preoperative, 6 months, and 12 months). Quadriceps and HS muscle strengths were measured with an isokinetic device. Proprioception was evaluated with reproduction of passive positioning for joint position sense and overall stability index (OSI) for dynamic postural stability. Patient-reported outcomes included the Lysholm score and the International Knee Documentation Committee score. Results: There were no significant differences in demographic information including age, body mass index, concomitant meniscal injuries, and sports activities ( P > .05) between HS tendon autograft and TA allograft groups. Quadriceps and HS strength in both groups, HS strength in deep knee flexion in both groups, and OSI in the HS tendon autograft group significantly improved at 12 months ( P < .05). Repeated-measures analysis of variance revealed significant interactions between time and grafts for OSI ( F[2, 136] = 5.08; P = .007). The subsequent independent t test demonstrated that the OSI was significantly higher in the TA allograft group (2.7 ± 1.0) than that of the HS tendon autograft group (2.1 ± 0.8) at 12 months ( P = .009), indicating better dynamic postural stability in the HS tendon autograft group. Conclusion: No significant differences were found in knee muscle strength or patient-reported outcomes between HS tendon autograft and TA allograft after ACLR with remnant preservation for up to 1 year except for dynamic postural stability favoring HS tendon autograft.
Perspectives of Midwives and Nurse Practitioners in Kentucky on Exercise Counseling During Pregnancy: A Qualitative Study
Authors: Perera Madhawa , Nagpal Taniya S. , Blankenship Maire M. , Tolusso Danilo V. , Cox Jordyn M. , Prashadika Dilini , Schafer Mark , Tinius Rachel A. 
Published: January 2025

Introduction Healthcare professionals are in an optimal position to deliver exercise information to pregnant women, yet previous research suggests this seldom happens. Midwives and nurse practitioners, who may have more time with pregnant women, are particularly well suited for this role. Objectives This qualitative study examined the exercise advice and counseling provided by midwives and nurse practitioners in Kentucky, focusing on the barriers they face. Methods Twenty-one midwives and nurse practitioners were recruited until the sample size reached saturation. A survey with open-ended questions was distributed to potential participants in regional hospitals, universities, and professional associations. The framework method was employed to identify common themes in the responses from participants. Results Five main themes emerged: nature of advice, discussing exercise benefits, safety concerns, barriers to counseling, and suggestions for improvement. Findings revealed that midwives and nurse practitioners recommend moderate exercise, aiming for 150 min weekly, monitoring heart rate for intensity, continuing prepregnancy exercise routines, starting low-intensity exercise during pregnancy such as walking, slowing down as pregnancy advances, and avoiding heavy lifting and vigorous activities. Many midwives and nurse practitioners in our sample took a reactive approach to exercise counseling, providing exercise advice if pregnant women asked questions or if they were at high risk for hypokinetic diseases. It was also observed that midwives and nurse practitioners discussed the maternal benefits of exercise more than the fetal benefits. Only a few nurse practitioners and midwives were content with their counseling, while the majority did not feel their counseling was effective. Conclusions Many midwives and nurse practitioners in Kentucky provided comprehensive and accurate physical activity guidelines to pregnant women. However, there is room for them to improve: proactive counseling should include discussions on fetal benefits and using the “talk test” for exercise intensity. Advising patients to slow down as pregnancy progresses should be reconsidered, and evidence-based guidance on specific exercises should be prioritized.
Comparison of oronasal and nasal masks in home mechanical ventilation: an observational cohort and bench study
Authors: Fresnel Emeline , Caillard Christian , Lebret Marius , Razakamanantsoa Léa , Kerfourn Adrien , Dupuis Johan , Muir Jean-François , Lhuillier Elodie , El Husseini Kinan , Similowski Thomas , Cuvelier Antoine , Patout Maxime 
Published: January 2025

BackgroundIn patients with chronic respiratory failure, home non-invasive ventilation (NIV) is delivered through oronasal or nasal masks. Masks are a cornerstone for NIV success but can be associated with side-effects. However, the type, frequency and consequences of these side-effects are unknown. Here, we aimed to study the prevalence, nature and impact of mask-related adverse events in a cohort of stable patients. We then investigated differences between oronasal and nasal masks both in our cohort and in a bench study.MethodsThis was a prospective observational cohort including patients established on long-term NIV admitted for their elective review. Data regarding mask-related side-effects were assessed using a structured questionnaire. Our bench study was performed using a three-dimensional printed head connected to an artificial lung.Results800 patients were included, of whom 84% had an oronasal mask. Moderate to very severe mask-related side-effects occurred in 47% of patients and severe to very severe side-effects occurred in 18% of patients. Side-effects were associated with poorer daytime arterial partial pressure of carbon dioxide (p=0.005), poorer subjective sleep quality (p=0.003) and poorer quality of life (p<0.001). Mask-related side-effects were more frequently reported with the use of oronasal masks compared to nasal masks (p=0.023). Our bench study showed that nasal masks were more stable than oronasal masks (p<0.001).ConclusionsMask-related side-effects are frequent and associated with poorer outcomes. Our data suggest that nasal masks may have a better tolerance profile and should be used as a first-line interface.
Simulator and on-road testing of truck platooning: a systematic review
Authors: Botelho Telmo Costa , Duarte Sérgio Pedro , Ferreira Marta Campos , Ferreira Sara , Lobo António 
Published: January 2025

Abstract
The evolution of transport technologies, marked by integrating connectivity and automation, has led to innovative approaches such as truck platooning. This concept involves linking multiple trucks through automated driving and vehicle-to-vehicle communication, promising to revolutionize the freight industry by enhancing efficiency and reducing operational costs. This systematic review explores the current state of truck platooning testing literature, focusing on simulator and on-road tests. The objective is to identify key scenarios and requirements for successfully developing and implementing the truck platooning concept. Following the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA) guidelines, we searched the Web of Science and Scopus databases, leading to the inclusion of thirty pertinent articles encompassing simulation-based, on-road, and mixed-environment experiments. In addition to the type of testing environment, these articles were assorted into three groups corresponding to their main thematic scope, human-centered, technology-centered, and energy efficiency studies, each providing unique insights into core themes for the development of truck platooning. The results reveal a commonly preferred platoon formation consisting of three trucks maintaining a constant speed of 80 km/h and a stable distance of 10 m between them. Simulator-based studies have predominantly concentrated on human factors, examining driver behavior and interaction within the platooning framework. In contrast, on-road trials have yielded tangible data, offering a more technology-driven perspective and contributing practical insights to the field. While the literature on truck platooning has grown considerably, this review recognizes some limitations in the existing literature and suggests paths for future research. Overall, this systematic review provides valuable insights to the ongoing development of robust and effective truck platooning systems.
Inequality of earnings and housing costs – developments between and within regions
Authors: Breidenbach Philipp , Schaffner Sandra 
Published: January 2025

Abstract
Household well-being is strongly influenced by changes in income – but real income is strongly determined by housing costs. The evolution of inequalities in both variables largely determines the development of living conditions between households. In this paper, we look at inequality trends between 2008 and 2017 from a regional perspective – between and within regions. While neighborhood earnings inequality has generally declined slightly, it is rising within Germany’s largest cities. On the other hand, inequality in rents has less declined within those cities than in the rest of Germany, corresponding to price increases in poorer neighborhoods, too. Households in these poor neighborhoods thus suffer from a below-average earnings development, while it seems that the main costs caused by new rentals increase similar to the rest of the city.
Case report: a rare concurrence of dense deposit disease in an adolescent patient with IgA nephropathy
Authors: Zhang Jian-Hui , Yu Hong-Ping , Chen Ying , Chen Qian , Zheng Xiao-Ling , Luo Jie-Wei , Zhang Li 
Published: January 2025

Abstract

Background
Dense deposit disease (DDD) is a rare renal disorder major affecting adolescents and children, characterized by an absence of distinctive clinical symptoms. Its coexistence with other renal conditions complicates both diagnosis and treatment in clinical practice.

Case presentation
We described a 15-year-old male adolescent presenting with nephrotic syndrome as the initial manifestation, with urinalysis indicating significantly elevated protein and erythrocytes. Unexpectedly, the renal pathological biopsy of the patient exhibited strong positivity for both IgA and C3, characterized by petaloid deposition of C3 along glomerular capillary loops and the glomerular mesangial region, as well as linear deposition in Bowman’s capsule and portions of the renal tubular basement membrane. Consequently, the patient was diagnosed with both DDD and IgA nephropathy. The presence of both in a single patient may result in more intricate pathogenic pathways.

Conclusions
This specific case elucidates the pathological characteristics of both diseases while investigating the intricate connections and lesion correlations that may occur between them, offering novel insights into their pathogenesis.