bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long-term Outcomes Of Mitomycin-C Augmented Trabeculectomy using Subconjunctival Injections Versus Soaked Sponges: A Randomized Controlled Trial
Authors: Maheshwari Devendra , Pillai Madhavi , HM Priya , Rengappa Ramakrishnan , Kadar Mohideen , Pawar Neelam 
Published: April 2023

Abstract

Purpose: To compare the safety and efficacy of subconjunctival injection of Mitomycin C(MMC) with sponge-applied MMC during trabeculectomy.Methods: This prospective, randomized, interventional study was conducted on consecutive patients with uncontrolled glaucoma. 137 patients were randomized into an Injection group(Group 1,n=66) and a sponge group(Group 2,n=71). Trabeculectomy was performed in all patients who were followed up on days 1, 15, 30, 3 months,6 months,1 year,2 years & 3 years postoperatively. Baseline & follow-up visits were compared to find out difference in the number of antiglaucoma medications (AGM ), Intraocular pressure(IOP), and Best Corrected Visual Acuity(BCVA).In Group 1, the surgeon used MMC 0.2 mg/ml as subconjunctival injection and two separate semicircular surgical sponges soaked with MMC solution of 0.2 mg/mL were inserted subconjunctivally in Group 2.Results:Mean preop IOP was 34.21±13.3mmHg& 34.17±10.6mmHg in group 1&2 respectively,which reduced to 11.34±3.7& 12.57±4.7mmHg(6 months),11.97±4.2& 13.60 ±5.3mmHg(1year),12.42±4.4& 11.77±2.8 mmHg(2years)&11.25±3.2&11.81±3.2mmHg at final visit(P<0.001 in both groups)with no significant difference between the groups.The mean number of preoperative AGM was 2.32±0.7&2.32±0.8 in group1&2 respectively which reduced to 0.78±0.9(P<0.001)&1.13±1.1(P=0.930)at 3 years.Overall success rates were 75.3% in group 1 and 70.7% in group 2 at 3 years(p=0.512). Postoperative complications and the final post-operative visual outcomes were similar between the groups.Conclusion: Subconjunctival Injection of MMC is as safe and effective as sponge application with comparable surgical outcomes and complications in the long term.
The impact of lenvatinib on sarcopenia in patients with advanced unresectable hepatocellular carcinoma
Authors: Praktiknjo Michael , Solano Ana S. Pena , Sadeghlar Farsaneh , Welchowski Thomas , Schmid Matthias , Möhring Christian , Zhou Taotao , Mahn Robert , Monin Malte B. , Meyer Carsten , Feldmann Georg , Brossart Peter , Beekum Cornelius , Semaan Alexander , Matthaei Hanno , Manekeller Steffen , Sprinkart Alois M. , Nowak Sebastian , Luetkens Julian , Kalff Jörg C. , Strassburg Christian P. , -Carmona Maria A. Gonzalez 
Published: April 2023

Abstract

Lenvatinib is a multiple receptor tyrosine kinase inhibitor (TKI) approved for first-line treatment of patients with unresectable hepatocellular carcinoma (HCC). TKI are suspected of exacerbating muscle wasting (sarcopenia) in patients with cancer. In this study, we analyze the role of sarcopenia in patients with advanced HCC treated with lenvatinib. This is a retrospective analysis of a real-life cohort of 25 patients with advanced HCC who were treated with lenvatinib from 2018 to November 2020 in Germany. Patients were stratified for loss of skeletal muscle index (SMI) during the first three months of lenvatinib therapy. Overall survival (OS), progression-free survival (PFS) and toxicity were analyzed for all patients, especially regarding development of sarcopenia before and during the first three months of therapy with lenvatinib. Three months after beginning of therapy with lenvatinib, a significant reduction of muscle mass was observed in 60% of patients (p = 0.035). Despite increase of sarcopenia, patients benefitted from lenvatinib in our cohort of patients in terms of OS and PFS and did not experience increased toxicity. Furthermore, muscle loss was not found to be a negative predictor of survival in the univariate analysis. Patients with advanced hepatocellular carcinoma experience muscle wasting with lenvatinib therapy. However, despite progressive sarcopenia, patients benefit from a therapy with lenvatinib in terms of OS and PFS without increased toxicity. However, assessment and prophylaxis of skeletal muscle status should be recommended during a therapy with lenvatinib.
Determination of Survival-Related Factors in Coronary Artery Disease by Using Machine Learning Algorithms
Authors: Tanbakuchi Davoud , Ghavami Vahid , Mobarhan Majid Ghayour , Esmaily Habibollah 
Published: April 2023

Abstract
The aim of this study was to use machine learning methods in determining the factors related to the survival of heart patients in Mashhad. Because survival studies play an important role in medical and health research. Numerous methods have been used in this field and have been published in various magazines. Obviously, each of these methods has its drawbacks. accordingly, much research has been done to find algorithms that can meet the challenges. But so far none of them have been able to overcome all the challenges. In this research, our goal is to introduce algorithms that can overcome the challenges as much as possible and have the appropriate speed and accuracy. So, we first examine the theoretical issues of each method and introduce a series of the most practical machine learning methods in survival analysis. In addition, we will compare the performance of these methods with conventional and classical methods of survival analysis such as the Cox regression method. Then, while presenting the research results, we examine the strengths and weaknesses of each algorithm.
Urinary L-FABP: a potential novel early biomarker for Diabetic Nephropathy? A systematic review of the literature
Authors: Satta Ersilia , Strollo Felice , Borgia Luisa , Guarino Giuseppina , Romano Carmine , Masarone Mario , Gentile Sandro 
Published: April 2023

Abstract
Introduction:
Patients with Type 1 and Type 2 diabetes mellitus (T1DM and T2DM) are at high risk of developing chronic kidney disease (CKD), i.e., diabetic nephropathy (DN), whose onset and progression are associated with a high morbidity and mortality risk. Early DN prediction is crucial. Presently it relies on albumin excretion rate (AER) and glomerular filtration rate (GFR) assessment. Nevertheless, recent literature reports that DN eventually affects patients with normal AER and GFR values. Therefore, further cost-effective biomarkers of DN onset or fast worsening are needed. Intracellular liver-type fatty acid-binding protein (L-FABP) has been associated with renal tubular-interstitial damage and could help predict and diagnose DN.
Methods: we performed a systematic review of the literature to evaluate the performance of urinary excretion of such biomarker (uL-FABP) in predicting and diagnosing DN and its progression in T2DM and T1DM patients. To do so, we evaluated 635 publications on four major scientific databases, 21 of which were suited for inclusion in this review.
Results: we selected twenty-one in-extenso publications, 14 reporting a cross-sectional design/arm (nine on T2DM, four on T1DM, and one on both). Ten included a longitudinal design/arm. Cross-sectional studies, primarily conducted in Asian and north-European populations, showed uL-FABP levels to correlate directly with DN severity (micro-, macro-albuminuria, and overt CKD) in T1DM and T2DM, besides being significantly higher than in healthy controls in the case of normoalbuminuria. In addition, longitudinal ones showed baseline uL-FABP to predict DN onset in normoalbuminuric patients with T1DM and DN progression independently of diabetes type.
Discussion: the studies analyzed in this review suggest that uL-FABP is a marker of tubular damage detectable before increased albumin excretion and can represent the earliest sign of kidney dysfunction in diabetes. Indeed, it discloses DN onset and often predicts DN severity from start to end-stage renal disease (ESRD) in T2DM and T1DM patients. Currently, uL-FABP can be assessed on a routine basis and, being available as a point-of-care fast test kit, may also become an easy-to-handle diagnostic tool for outpatients.
Conclusions: uL-FABP represents a cost-effective and user-friendly biomarker of DN and can even predict DN progression in T2DM and T1DM over time.
Hemorrhagic fever with renal syndrome complicated by plasmacytosis mimicking multiple myeloma: A case report
Authors: Qian Long , Feng Ru , Wang Ting , Liu Hui , Bai Jiefei 
Published: April 2023

Abstract
Background Hemorrhagic fever with renal syndrome (HFRS) is a zoonosis endemic with atypical early clinical manifestations, and it is very easy to be misdiagnosed. Up to now, there has been no report on plasmacytosis caused by HFRS. Here we report a case of HFRS complicated by plasmacytosis mimicking multiple myeloma.Case presentation: We present an atypical case of HFRS, with the patient exhibiting both bone marrow and peripheral blood plasmacytosis during the course of illness. Besides, the patient presented with lymphadenopathy and was diagnosed with AITL and died soon due to cardiogenic shock.Conclusions HFRS should be one of differential diagnosis of plasmacytosis in certain endemic area.
Investigating an efficient processing strategy of SiCf/SiC composites during single grain scratching under minimum quantity lubrication.
Authors: Zhang Qi , Wang Ben , Song Chang , Wang Hao , Shi Zhongao 
Published: April 2023

Abstract
With the rapid development of processing technology, increasing processing efficiency is no longer the only goal but also the utilization of green and clean manufacturing procedures is required. In this context, the development of an efficient processing strategy for ceramic matrix composites (CMCs) is of great importance. Although SiCf/SiC composites are regarded as one of the most novel fiber-reinforced ceramic matrix composites, their processing is quite difficult. Along these lines, in this work, the orthogonal test of single-grain scratches was conducted under different lubrication modes. From the acquired results, it was demonstrated that compared with the dry type, the minimum quantity lubrication (vegetable oil) lubrication method exhibited the best effect, the scratch force was reduced by 48.3%, and the surface uplift height was reduced by 48.4%. The dominant mode of material removal of the SiCf/SiC composites was a brittle fracture, and the damage characteristics mainly included natural fiber fracture, matrix breakage, fiber pullout, and fiber exposure. In addition, the scratch depth and the scratch angle are the key factors affecting the processing quality. Increasing the processing ratio of 0° and using MQL (vegetable oil) have yielded the best results.
Early stage nanocrystallization as a method of enhancement of electrical properties of lead/barium titanate doped vanadium borate glasses
Authors: Harby Amany E. , Hannora Ahmed E. , Ali Atif Mossad , El-Desoky M. M. 
Published: April 2023

Abstract
Glass-ceramic nanocomposites (GCNs) of (10x) BaTiO3 (BT)-xPbTiO3 (PT) -60V2O5-30B2O3 with x= 0, 2.5, 5, 7.5 and 10 mol% were formed during heat treatment of conventional melt quenching glasses. X-ray diffraction was used to ensure glass and GCNs formation. Glasses and GCNs densities were measured by Archimedes principle. Fine polar clusters of lead titanate and/or barium titanate incorporation into vanadium borate glass matrix strongly depend on the composition. It was found out that the electrical conductivity of the initial glasses can be considerably improved by proper early stage of nanocrystallization at temperatures approaching the crystallization temperatures determined by DSC method. GCNs show massive increase in electrical conductivity (up to 6 orders of magnitude) as a function of BaTiO3 content. By increasing BaTiO3 content, the activation energy values have been found to increase. The enhancement in electrical conductivity of GCNs can be attributed to the increase in the crystalline phases in the glassy matrix which increases the concentrations of the V ion pairs.
Intravenous Immunoglobulin Use in Pediatric Intensive Care: A Single-Center Experience
Authors: Gurbanov Anar , Gün Emrah , Botan Edin , Balaban Burak , Kahveci Fevzi , Özen Hasan , Uçmak Hacer , Havan Merve , Kendirli Tanıl 
Published: April 2023

Abstract
Purpose: The clinical applications of intravenous immunoglobulin (IVIG) therapy in critically ill children are increasing. Here we share our single-center experience with the use of IVIG in the pediatric intensive care unit (PICU).
Methods: This retrospective study included patients treated with at least one dose of IVIG in the PICU between November 2019 and April 2022.
Results: A total of 68 patients (44 males) were included in the study. The most common indications for IVIG were rheumatologic (43%), infectious (34%), and neurological diseases (14.5%). Twenty-one patients (30%) died. The frequency of chronic disease was 28% among survivors and 76% among non-survivors (p=0.0001). The indication for IVIG was septic shock in 71% of non-survivors (p=0.0001) and multisystem inflammatory syndrome in children in 57% of survivors (p=0.0001). Non-surviving patients had lower median IVIG dose per actual body weight (0.5 vs. 1 g/kg, p=0.02) and cumulative IVIG dose (30 vs. 60 g, p=0.04). In multivariate logistic regression analysis to determine mortality predictors in patients using IVIG, the presence of chronic disease was found to strongly increase mortality (odds ratio: 5.7, 95% confidence interval: 1.5-21, p=0.01). IVIG-related parameters (body weight, number of IVIG doses, cumulative IVIG dose) were not predictors of mortality (p>0.05).
Conclusions: Although we observed that the surviving patients in our study received more IVIG than non-survivors, the amount of IVIG was not found to be associated with mortality.
Spleen-preserving pancreatectomy with splenic vessels removal : impact on splenic parenchyma ?
Authors: LETE Coralie , BRICHARD Martin , ROSA Maria Luisa , SALAVRACOS Mike , HUBERT Catherine , NAVEZ Benoit , CLOSSET Jean , PEZZULLO Martina , NAVEZ Julie 
Published: April 2023

Abstract
Background While outcomes after spleen-preserving distal pancreatectomy (SP-DP) are widely reported, the impact on splenic parenchyma is poorly studied. This study aimed to assess splenic imaging after SP-DP with splenic vessels removal or preservation, and to compare postoperative outcomes especially spleen-related.Methods All patients undergoing SP-DP with splenic vessels removal (Warshaw technique, WDP) or preservation (Kimura technique, KDP) between 2010 and 2022 in two tertiary centres were retrospectively analysed. Splenic ischemia and volume at early/late imaging and postoperative outcomes were reviewed.Results Ninety-five patients were included, 57 in WDP and 38 in KDP groups. The median age and Charlson’s Comorbidity Index were significantly higher in WDP group compared with KDP group. Postoperative morbidity was similar between groups. There was more splenic ischemia at early imaging in WDP compared to KDP groups (53% vs. 14%, p = 0.007), especially severe ischemia (22% vs. 0). Splenic partial atrophy was observed in 30% and 0% of WDP and KDP groups, respectively (p < 0.001); no complete splenic atrophy appeared. There was no significant difference between groups in haematological parameters (haemoglobin, platelets, white blood cells and CRP levels) until postoperative day 6. Charlson Comorbidity Index and postoperative day 6 platelets levels were prognostic factors of splenic atrophy at multivariate analysis. No episodes of overwhelming post-splenectomy infection or secondary splenectomy were recorded after a median follow-up of 9 and 11 months in WDP and KDP groups, respectively.Conclusions Splenic ischemia appeared in one half of patients undergoing SP-DP with splenic vessels removal at early imaging, and partial splenic atrophy in 30% at late imaging, without clinical impact neither complete splenic atrophy. Charlson Comorbidity Index and postoperative day 6 platelets levels could help to predict the occurrence of splenic atrophy.
Trust in Health Services After Covid-19: Believing to Trust, Knowing to Believe
Authors: KURŞUN Arzu 
Published: April 2023

Abstract
Aim This research aims to measure the multidimensional trust and health perception of individuals in health services through health literacy under the conditions of COVID-19.Method This research was a relational, descriptive and cross-sectional study. Also, SPSS 22.0 package program, R 4.2.2 package program and Rstudio were used for the statistical analysis of the study.Results 71.5% of the participants are female and 28.5% are male. 5.4% are married, 94.6% are single. The effect of health perception on multidimensional trust in health services was significant (B = .261 ± 0.031; β = 0.262; p = 0.000 < 0.05). Additionally, the effect of health literacy on multidimensional trust in health services was also significant (B = 0.072 ± 0.026; β = 0.083; p = 0.007 < 0.05). Finally, health literacy was found to have a significant effect on health perception (B = 0.192 ± 0.020; β = 0.272; p = 0.000 < 0.05).Conclusion Especially during the pandemic period, health literacy affected health perception and trust in health services. It showed a partial mediator variable feature on health literacy, health perception and multidimensional trust in health services.
The Impact of rapid urban growth on land use and land cover change and urban heat island: The case of Babuzai, Pakistan
Authors: Fahad Shah , Li Wei , Valjarević Aleksandar , Kavroudakis Dimitris , Sharifi Ayyoob 
Published: April 2023

Abstract
Land use and land cover (LULC) change is one of the consequences of rapid urbanization that has implications for the environment and climate change. This research aims to examine changes in LULC and the associated spatiotemporal impacts on the urban heat islands (UHI). For this purpose, we used Multi-temporal Landsat data and correlation analysis to track the LULC pattern and land surface temperature (LST) in the study area over the last 24 years. The study revealed that the built-up area and grass & agricultural land increased from 3.19% to 18.53% and 19.13 % to 26.81 %, respectively, from 1998 to 2022. The LULC change and anthropogenic causes influenced the spatial distribution of LST. LST increased by 0.37 ◦C per/year; areas with dense built-up areas had higher temperatures, while areas covered by vegetation cover, and forest land had lower temperatures. There is a strong correlation between LST and Normalized Difference Built-up Index (NDBI), while a low correlation between LST and Normalized Difference Vegetation Index (NDVI). For the relationship between NDBI and LST and NDVI and LST scatterplots used, they had a value (R2) of 0.9939 in 1998 and 0.9583 in 2022 and 0.9872 in 1998 and 0.9835 in 2022, respectively. The study indicates that the development of UHI is influenced by urbanization and deforestation, which leads to an increase in LST. Urban planners and decision-makers can utilize the findings of this research to develop and implement sustainable land-use strategies and management practices for the city, which can have significant benefits.
Clinical features of severe ovarian hyperstimulation syndrome with hydrothorax
Authors: Wang Yang , Ma Xiaowei , Yang Rui , Yang Shuo , Li Jia , Pan Ningning , Li Rong 
Published: April 2023

Abstract
Research question: Does the presence of hydrothorax suggest that severe ovarian hyperstimulation syndrome (OHSS) is associated with more severe conditions and worse pregnancy outcomes?Design: The clinical data for 868 hospital patients with severe OHSS following IVF-ET at Peking University Third Hospital between January 1, 2016, and July 21, 2021, were retrospectively analysed. The patients were divided into two groups: the ascites alone group (n = 417) and the ascites combined with hydrothorax group (n = 451) to investigate the clinical features and pregnancy outcomes of patients with severe ovarian hyperstimulation syndrome (OHSS) combined with hydrothorax plus ascites.Results The clinical data for 868 hospital patients with severe OHSS following IVF-ET were included. The patients were divided into two groups: the ascites alone group (n = 417) and the ascites combined with hydrothorax group (n = 451). 51.96% of patients with severe OHSS had hydrothorax plus ascites, mainly bilateral and moderate hydrothorax. Most cases with hydrothorax could be monitored and observed, and only 2.66% of the cases required thoracentesis and pleural drainage. Clinically, time to visit due to worsening symptoms was longer; hospital stay was shorter; and OHSS-related laboratory tests such as white blood cells (WBC), haematocrit (HCT), and ovarian diameter were less severe in the ascites combined with hydrothorax group than in the ascites alone group. For live-birth outcomes of IVF-ET, the presence and the volume of hydrothorax were not independent risk factors, while late onset of OHSS (odds ratio [OR]: 0.857 95% confidence interval [CI]: 0.795, 0.925) and a history of foetal reduction (OR: 13.796 95% CI: 1.808, 105.288) were independent protective factors for live birth.Conclusion Patients with severe OHSS combined with hydrothorax plus ascites have less severe clinical manifestations and laboratory tests than those with ascites alone. The presence and the volume of hydrothorax are unrelated to live-birth outcomes following in vitro fertilization and embryo transfer (IVF-ET).
WITHDRAWN: Fasting blood glucose level and all-cause mortality in peritoneal dialysis patients
Authors: Lim So Jin , Moon Ju Young , Jeong Kyung Hwan , Ko Gang-Jee , Choi Yun Jin , Hwang Hyeon Seok 
Published: April 2023

Abstract
Glycemic control is particularly important in peritoneal dialysis (PD) patients with diabetes. Although fasting blood glucose (FBG) is the most commonly used index to measure blood glucose levels, there is currently no conclusive evidence to establish the target FBG level for PD patients. A total of 3,548 patients with diabetes who underwent PD between 2002 and 2018 were enrolled using data from the National Health Insurance Service database of Korea. We investigated the association between time-varying FBG levels and the risk of all-cause mortality. During an average follow-up period of 6.55 years, a total of 1,366 mortality events were identified. Patients with FBG levels 80–99 mg/dL exhibited the highest survival rates, while those with FBG levels ≥ 180 mg/dL had the lowest survival rates. Compared to patients with FBG levels of 80–99 mg/dL, the adjusted hazard ratios (HR) for all-cause mortality significantly increased with an elevation in FBG levels. Additionally, the HR for all-cause mortality was higher in patients with FBG levels < 80 mg/dL compared to those with FBG levels of 80–99 mg/dL. A J-shaped association was observed between FBG levels and the risk of all-cause mortality, which was the lowest at FBG 80–124 mg/dL in PD patients with diabetes.
Automated Document Orientation Correction Using Skew and Inversion Rectification with Hough Line Transformation and Machine Learning
Authors: Shafi Sadaf , Atif Amara , shafi Huzaib 
Published: April 2023

Abstract
Document deskewing is a fundamental problem in document image processing. While existing methods have limitations, such as Hough Line Transformation that can deskew images upside down, and Deep Learning models that require huge amounts of human labour and computational resources and still fail to deskew while taking care of orientation, OCR-based methods also struggle to read text when it is tilted. In this paper, we propose a novel, simple, cost-effective deep learning method for fixing the skew and orientation of documents. Our approach reduces the search space for the machine learning model to predict whether an image is upside down or not, avoiding the huge search space of predicting an angle between 0 and 360. We finetuned a MobileNetV2 model, which was pre-trained on imagenet, using only 1000 images and achieved good results. This method is useful for automation-based tasks, such as data extraction using OCR technology, and can greatly reduce manual labour.