bluuebunny/crossref_metadata_2025_split huggingface dataset:
Natural history of Echinococcus granulosus microcyst development in long term in vitro culture and molecular and morphological changes induced by insulin and BMP-4
Authors: Derakhshani Ali , Mousavi Seyed Mohammad , Rezaei Masoud , Afgar Ali , Keyhani Ali Reza , Mohammadi Mohammad Ali , Dabiri Shahriar , Fasihi Harandi Majid 
Published: January 2023

IntroductionCystic echinococcosis (CE) caused by the cestode Echinococcus granulosus is a disease of worldwide public health and economic importance. The determinants and underlying cellular mechanisms of CE development and fate in intermediate hosts are largely unknown. Hormones and cytokines such as insulin and BMP-4 are the key players in the development, differentiation, and apoptosis. In this study, we evaluated the long term natural history of E. granulosus microcysts in an vitro setting and the molecular and morphological changes induced by the growth factors, insulin and BMP4 during the development of metacestode stage of E. granulosus.MethodsE. granulosus protoscoleces were cultivated and the parasite development was followed in the long term mono-phasic culture for 105 days and the morphometric, molecular and immunohistochemical changes were evaluated, including the microcysts number and size, microcysts development and deformation rates as well as the markers of calcification (Alizarin Red staining) and apoptosis (BAX, BCL2, Caspase-3, Caspase-8 and TNF-α expression) in the microcysts. Also the biological, histological and molecular consequences of insulin and BMP-4 treatment on the parasite development were evaluated.ResultsInsulin and BMP-4 treatment of microcysts resulted in significant increase in microcyst formation, increased size, reduced apoptosis and deformation of the microcysts. Alizarin red staining of the microcysts treated with the insulin and BMP-4 confirmed that calcium deposition is significantly lower than the untreated microcysts. Also Alizarin Red staining and Immunohistochemistry of the microcysts indicates that calcium accumulation in deformed microcysts is higher than the normal ones on day 105. The microcysts began to wrinkle and the germinal layer was partially detached from the laminated layer on day 84.ConclusionResults of the present study suggest that the degenerative changes in hydatid cysts can be slowed down by insulin and BMP-4, indicating that cellular factors and host hormones could contribute to the longevity of hydatid cysts. Significant evidences are provided suggesting that the microcysts cultivated in vitro can undergo calcification and apoptotic processes similar to what have been observed in the natural hydatid infection in the intermediate hosts.
Beta-glucans induce cellular immune training and changes in intestinal morphology in poultry
Authors: Bar-Dagan Hadar , Gover Ofer , Cohen Natalie Avital , Vetvicka Vaclav , Rozenboim Israel , Schwartz Betty 
Published: January 2023

IntroductionBeta-glucans are known as biological response modifiers due to their ability to activate the immune system. This research aimed to determine the efficacy and safety of feeding beta-glucans from various sources on the immune status and intestinal morphology of chickens.MethodsTo this end we used in vitro and in vivo set-ups. In the in vitro set-up the chicken macrophage cell line HD-11 was used to measure the response of the chicken immune cells to beta-glucans extracted from algae and mushrooms on immune-related gene expression and associated activities. Additionally, we conducted two in vivo experiments using either beta-glucans extracted from yeast or mix of yeast and mushrooms beta-glucans as part of the chicks feed in order to test their effects on the chick intestinal morphology.ResultsIn the in vitro set-up exposure of HD-11 cells to a concentration of 1 mg/ml of algae and mushroom beta-glucans resulted in significantly higher expression of 6 genes (TNFα, IL4, IL6, IL8, IL10, and iNOS2) compared to control. The release of nitrite oxide (NO) to the medium after exposure of HD-11 cells to mushrooms or algae beta-glucans was significantly increased compared to control. Additionally, significantly increased phagocytosis activity was found after exposure of the cells to algae and mushroom beta-glucans. In the in vivo set-up we observed that the length of the villi and the number of goblet cells in the ileum and the jejunum in the beta-glucan fed chicks were significantly augmented compared to control, when the chicks were fed with either yeast or yeast and mushroom beta-glucans mix.DiscussionIn conclusion, dietary supplementation of poultry with beta-glucan exerts significant and positive effects on immune activity and the intestinal morphology in poultry.
Social Media Overload and Anxiety Among University Students During the COVID-19 Omicron Wave Lockdown: A Cross-Sectional Study in Shanghai, China, 2022
Authors: Wang Yangyang , Xu Jian , Xie Tian 
Published: January 2023

Objectives: The increase in the intensity of social media use during the COVID-19 lockdown has affected mental health. Therefore, it is of practical implications to explore the association between social media overload and anxiety and the underlying mechanisms.Methods: Using data from 644 university students during the COVID-19 blockade in Shanghai from March to April 2022, the chain mediation model of information strain and risk perception of omicron between social media overload and anxiety was then tested using the macro PROCESS4.0 tool.Results: The findings showed that social media overload (including information overload and social overload) was positively associated with anxiety. This relationship was mediated by information strain and risk perception of Omicron. A chain mediating role of information strain and risk perception of Omicron has also been proved in this study.Conclusion: Social media overload has a positive effect on anxiety by increasing information strain and risk perception of Omicron. This study provides some implications for future interventions on how to use social media properly for mental health during the pandemic and health management of urban governance.
Roda de conversa sobre o orgasmo feminino em uma Unidade Básica de Saúde: um relato de experiência
Authors: Lima Uirassú Tupinambá Silva de , Silva Maria José Ribeiro Sampaio , Oliveira Ingrid Alana dos Santos , Goes Samya Manoella Vieira de Vasconcelos 
Published: January 2023

Introdução: A definição clássica do orgasmo feminino afirma que "consiste num pico sensorial variável e transitório de intenso prazer que cria um estado alterado de consciência, que começa com explosões de contracções involuntárias e rítmicas da musculatura pélvica estriada circunvaginal, com a presença concomitante de contracções uterinas e anais e miotonia Objetivo geral: relatar a experiência de uma roda de conversa sobre o orgasmo feminino na perspectiva de professores e estudantes de enfermagem em uma Unidade Básica de Saúde. Método: Esta pesquisa narra um relato de experiência de um grupo de professores e estudantes de enfermagem na condução de uma roda de conversa feminina sobre o orgasmo, na qual se buscou oportunizar educação em saúde, acolhimento e escuta terapêutica. Resultados/Discussão: O orgasmo precisa ser tratado de maneira singular, pois cada mulher sente e vivencia esse momento de uma forma diferente, levando em consideração a realidade de cada uma. A relação entre o orgasmo e o bem-estar físico e mental foi nítido, na discussão do grupo. Conclusão: As descobertas indicam que as mulheres diferem muito umas das outras em termos de como atingem o orgasmo, e em como descrevem tal sensação. O protagonismo da mulher na promoção do próprio prazer foi uma das barreiras desmistificadas durante a reunião, o que gerou empoderamento para o grupo.
Paradigma Azyumardi Azra Tentang Pendidikan Islam Multikultural dan Implikasinya di Era Pandemi COVID -19
Authors: Shaleh Munif , Mahmudi Mahmudi 
Published: January 2023

Penelitian ini menelaah tentang pemikiran Azyumardi Azra tentang pendidikan Islam multicultural. Penelitian ini termasuk dalam penelitian kualitatif. Data diperoleh dari hasil telaah kepustakaan. Diskursus pendidikan multicultural memang sudah banyak dibahas, akan tetapi tataran praksisnya masih dapat dihitung jari. Pandangan Azra tentang pendidikan Islam multicultural selalu bergandengan dengan tujuan agama Islam. Dasar dari pendidikan Islam multicultural secara religious merupakan fitrah manusia yang diciptakan berbeda-beda. Dari segi falsafah kebangsaan, pendidikan Islam multicultural hadir dari semboyan Bhineka Tunggal Ika. Hasil dari pendidikan Islam multicultural adalah kepribadian peserta didik yang tidak hanya bertakwa, beriman, bermoral, tapi juga mempunyai sikap menghargai perbedaan dan berpengetahuan moderat.
Selected aspects of ensuring accessibility of historical buildings for people with mobility impairments
Authors: Rymsza Barbara , Kaperczak Krzysztof 
Published: January 2023

The paper is devoted to the problem of providing people with mobility impairments, in wheelchairs, with crutches and the elderly, with access to monumental buildings located in the historic public space.
The authors present current technical and construction regulations concerning passageway infrastructure and the needs that result from limitations in people with mobility impairments.
Proposals for solutions to improve accessibility were also presented in a graphic form, making it easier to understand the intent of the proposed solution and showing examples of already applied solutions.
The paper addresses the problem of adaptation of sidewalks, parking spaces and entrances to buildings to the needs of such people while maintaining the recommendations on issues arising from the protection of cultural heritage, conservation recommendations and the historical nature of the space around monuments.
The authors of this paper have been working for years on the subject of accessibility of public space for people with disabilities, based on their own experience as a wheelchair user.
This article should serve as a prompt for historic site administrators on how, with minimal intervention, accessibility to historic sites can be improved and how to enable people with special needs to enjoy cultural assets.
Inclusive approaches in historic green spaces
Authors: Sikora Dorota 
Published: January 2023

Abstract
Zgodnie z ideami zrównoważonego rozwoju zawartymi w rezolucji ONZ "Przekształcamy świat: Agenda 2030 na rzecz zrównoważonego rozwoju" do kluczowych celów, jakich osiągnięcie założono do 2030 r., należą między innymi: zapewnienie powszechnego dostępu do bezpiecznych dla wszystkich i inkluzywnych terenów zieleni oraz przestrzeni publicznych, a jednocześnie wzmocnienie wysiłków na rzecz ochrony dziedzictwa kulturowego i przyrodniczego. W artykule przedstawiono, na wybranych przykładach zabytkowych parków, ogrodów oraz krajobrazów, jak cele te są realizowane. Przedmiotem badań były w szczególności: Ogród Wersalski, Stonehenge i krajobraz kulturowy otaczający ten zabytek, zarządzany przez English Heritage, a także polityka udostępniania zabytkowych, parków, ogrodów i krajobrazów, realizowana przez Historic England.
Analiza strategii udostępniania zabytkowych terenów zieleni i krajobrazów kulturowych osobom ze szczególnymi potrzebami, wypracowanych przez wymienione powyżej instytucje, pozwoliła na sformułowanie w podsumowaniu artykułu propozycji ogólnych założeń inkluzywnej polityki względem tej grupy zabytków.
Ogrody zabytkowe – czy dla wszystkich?
Authors: Stachańczyk Renata 
Published: January 2023

Wśród wielu kategorii zabytków dostępność ogrodów zabytkowych stanowi zagadnienie nadal słabo rozpoznane. Wymagania ustawowe koncentrują się na dostępności budynków i nie nakładają obowiązku dbania o przestrzeń otaczającą. Pomijają więc teren otaczający budynek, który jest najczęściej jego niezbędnym dopełnieniem i często podlega ochronie prawnej jako wpisane do rejestru zabytków otoczenie, ogród lub park, jako część zespołu czy zabytku obszarowego. Zapewnienie dostępności zabytków, w tym ogrodów zabytkowych jest zagadnieniem wspólnym dla budynku i jego zabytkowego otoczenia - obszernym i złożonym, które należy analizować kompleksowo, w kontekście całego obiektu zabytkowego.
W jego realizacji nie chodzi jednak o dopasowanie zabytku do wymogów dostępności - w rozumieniu przebudowy całości czy jego części, ale o wybór odpowiedniej opcji udostępniania – czyli zapewnienia takich rozwiązań, które nie wiążą się z nadmiernym obciążeniem, czy naruszeniem wartości ogrodu zabytkowego, w przeciwnym wypadku byłoby to sprzeczne z zasadami ochrony konserwatorskiej tych obiektów. Udostępnienie obiektu poprzez rozwiązanie kwestii dostępności architektonicznej może być skutecznie wspierane przez działania w sferze komunikacyjno-informacyjnej, które wydają się znacznie bezpieczniejsze w kontekście negatywnego wpływu na wartości zabytkowe obiektu niż likwidacja barier architektonicznych. Podstawowym warunkiem, który musi być przy tym spełniony jest przekazanie różnym grupom zainteresowanych uczciwej i wyczerpującej informacji o przygotowanej ofercie i o ewentualnych ograniczeniach dostępności. Ze względu na charakter zabytków obszarowych należy się spodziewać, że rzadko kiedy zarządzający ogrodem, będzie w stanie udostępnić go w pełni.
Показатели качества и безопасности нетрадиционных видов муки для производства безглютеновых макаронных изделий
Authors: Абуова Алтынай Бурхатовна , Муслимов Нуржан Жумартович , Кабылда Анар Идашкызы 
Published: January 2023

Введение. По данным ВОЗ, ежегодно до 30% населения промышленно развитых стран страдает болезнями пищевого происхождения. Научной основой современной стратегии производства безглютеновых продуктов питания служит изыскание новых ресурсов, обеспечивающих оптимальное для организма больных целиакией соотношение питательных элементов, в то же время безопасных пищевых продуктов. Цель. Изучить показатели качества и безопасности нетрадиционных видов муки из казахстанского сырья для производства безглютеновых макаронных изделий.Материалы и методы. Объектами представленных исследований служили рисовая, гречневая, кукурузная, нутовая виды муки, полученные из казахстанского сырья: риса (Кызылординская область), гречихи (Павлодарская область), кукурузы (из Алматинской области) и нута. На первом этапе исследований определили физико-химических показатели качества и микробиологические показатели безопасности безглютеновых видов сырья для производства безглютеновых макаронных изделий российских и казахстанских производителей. На втором этапе исследований получены экспериментальные образцы безглютеновых макаронных изделий с использованием гречневой, кукурузной и рисовой муки и определены физико-химические и микробиологические показатели полученных новых безглютеновых макаронных изделий.Результаты. В Казахстане есть возможность возделывания сельскохозяйственных. культур, не содержащих глютен. В Республике Казахстан рис возделываются в Кызылординской, Туркестанской и Алматинской областях и на 2020 год засеяно 230 тысяч гектаров, при средней урожайности 61,8 ц/га валовый сбор составил 551 тыс тонн, при внутреннем спросе 133 тыс. тонн. Из Казахстана 35-38 процентов из 551 тыс тонн риса экспортируется в качестве сырья. Выводы. По результатам проведенных исследований разработан технология безглютеновой муки и макаронных изделий с использованием сырья Республики Казахстан из смеси гречневой муки и кукурузной муки, а также смеси кукурузной и рисовой муки, которые по физико-химическим, микробиологическим и показателям безопасности соответствуют действующим нормативным документам и имеют хороший товарный вид. Результаты исследований имеют мультипликативный эффект: спрос на безглютеновые виды муки приведет к диверсификации растениеводства и к увеличению посевных площадей риса кукурузы, проса, масличных и бобовых культур и возрождению новых перерабатывающих предприятий различной мощности.
Pelatihan Reference Managemenet Software (RMS) Zotero dalam pengelolaan Sumber Rujukan Penelitian
Authors: Asy’ari Muhammad , Hunaepi Hunaepi , Mirawati Baiq , Armansyah Armansyah , Rahmawati Helmi 
Published: January 2023

Kurangnya pemahaman dan keterampilan mahasiswa dalam menggunakan Reference Managemenet Software (RMS) Zotero menjadi kendala dalam menyusun sumber pustaka yang sistematis dan presisi. Pengabdian Kemitraan Masyrakat ini bertujuan untuk meningkatkan pemahaman dna keterampilan mahasiswa pendidikan biologi menggunakan Reference Managemenet Software (RMS) Zotero dalam pengelolaan sumber rujukan. Mitra dalam kegiatan ini adalah mahasiswa semester enam program studi pendidikan biologi Universtas Pendidikan Mandalika, jumlah mitra yang terlibat 6 orang mahasiswa. Metode pelaksanaan adalah knowledge transfer dan Model Community development dengan tahapan kegiatan; 1) plan, 2) implementation, dan 3) evaluation. Setelah kegitan dilaksanakan terdapat peningkatan pemahaman dan keterampilan mitra dalam memanfaatkan Reference Managemenet Software (RMS) Zotero dalam pengelolaan sumber rujukan. Keterampilan menggunakan RMS Zotero penting untuk dimiliki oleh mahasiswa yang sedang menempuh matakuliah tugas akhir, sehingga materi tetang RMS Zotero ini perlu menjadi salah satu pokok bahasan dalam mata kuliah teknik penulisan artikel ilmiah.
Zotero Reference Management Software (RMS) training in managing Research Reference Sources for Biology Education Students
The lack of students' understanding and skills in using Zotero's Reference Management Software (RMS) becomes an obstacle to compiling systematic and precise library sources. This Community Partnership Service aims to improve the understanding and skills of biology education students using Zotero's Reference Management Software (RMS) in managing referral sources. Partners in this activity are sixth-semester students of the Biology education study program at the Mandalika Education University, the number of partners involved is 6 students. The implementation method is a knowledge transfer and Community development model with activity stages; 1) plan, 2) implementation, and 3) evaluation. After the activity was carried out there was an increase in partners' understanding and skills in utilizing Zotero's Reference Management Software (RMS) in managing referral sources. The skill of using RMS Zotero is important for students who are taking final project courses, so this material about RMS Zotero needs to be one of the topics in the technical article writing engineering course.
Pelatihan Manajemen Sitasi (Penggunaan Mendeley) Pada Dosen dan Mahasiswa PSDKU UNTAD Morowali
Authors: Hilmansyah Teguh , Sastrawan Erwan , Amin Mohammad , Wanti Sri , Anisah Anisah , Nurdin Sukardi 
Published: January 2023

Artikel ilmiah merupakan sesuatu yang sangat penting dalam dunia kampus khususnya untuk mahasiswa dan dosen dimana bagi mahasiswa artikel ilimiah adalah syarat wajib untuk kelulusan sedangkan bagi dosen merupakan salah satu kewajiban tridarma perguruan tinggi serta sebagai syarat kenaikan pangkat dosen. Penggunaan aplikasi Mendeley Bagi mahasiswa merupakan salah satu kebutuhan untuk menulis skripsi dan menjadikan sebagai salah satu penyimpanan referensi skripsi sedangkan bagi Dosen pelatihan Mendeley mendorong percepatan publikasi ilmiah pada jurnal internasional bereputasi. Pelakasanaan Pengabdian Kepada Masyarakat (PkM) Pelatihan Penggunaan Mendeley dilaksanakan pada Program Studi Diluar Kampus Utama (PSDKU) UNTAD Morowali dengan pesertanya adalah mahasiswa sebanyak 45 orang, dan Dosen sebanyak 5 orang. Metode pelaksanaan yang digunakan pada Pelaksanaan PkM menggunakan dua Metode yakni knowledge transfer dan Model Community development dengan tahapan pelaksanaa; 1) perencaanaa, 2) Pelaksanaa, dan 3) evaluasi .pemaparan materi dilakukan melalui tatap muka di Program Studi Diluar Kampus Utama (PSDKU) UNTAD Morowali. Hasil dari kegiatan ini adalah 40 mahasiswa dan 5 dosen peserta sudah mampu untuk melakukan download, instalasi aplikasi plug in pada Ms. Word, mensitasi artikel, mencari referensi jurnal dan membuat daftar pustaka secara otomatis
Citation Management Training (Using Mendeley) for Lecturers and Students of PSDKU UNTAD Morowali
Scientific articles are something that is very important in the campus world, especially for students and lecturers, where students scientific articles are a mandatory requirement for graduation, while for lecturers it is one of the three obligations of higher education as well as a requirement for a promotion. from the lecturer. The use of the Mendeley application is a necessity for students to write theses and use it as a repository of thesis references, while for lecturers the use of Mendeley is needed to accelerate scientific publications in reputable international journals. The Community Service Training (PKM) with Mendeley was held Program Studi Diluar Kampus Utama (PSDKU) UNTAD Morowali with 45 students and 5 lecturers as participants. The implementation method used in the implementation of PkM uses two methods, namely the transfer of knowledge and the Community development model with the stages of implementation; 1) planning, 2) implementation, and 3) evaluation. The material was delivered face-to-face at the Main Campus Off-campus Study Program (PSDKU) UNTAD Morowali. The results of this activity were that 40 students and 5 participating lecturers were able to download, and install plug-in applications on Ms. Word, cite articles, look for journal references, and create bibliographies automatic.