bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pemberdayaan Kepatuhan Wajib Pajak Perorangan, Perhitungan Dan SPT Tahunan Secara E-Filling
Authors: Mappadang Agoestina , Sinaga Melan , Adi Puput Dani Prasetyo 
Published: September 2023

Setiap orang pribadi yang sudah memenuhi dua unsur yaitu memiliki kewajiban pajak secara subjektif dan kewajiban pajak secara objektif. Maka memiliki kewajiban untuk melakukan pelaporan SPT Tahunan Orang Pribadi berdasarkan sistem “selft assessment” apabila sudah memiliki Kartu NPWP. Dengan perkembangan kemajuan zaman di era digitalisasi, maka sistem pelaporan yang sebelumnya hanya bersifat manual, kini telah beralih ke sistem digital. Sehingga setiap wajib pajak akan dipermudah dalam pelaporan perpajakan melalui sistem “efilling” dalam laman website Direktorat Jenderal Pajak (DJP). Permasalahan yang terjadi karena kurangnya pemahaman masyarakat khususnya mitra dalam pengetahuan perpajakan dan pelaporan pajak dan juga penggunaan sistem elektronik. Tujuan sosialisasi ini agar masyarakat sebagai wajib pajak orang pribadi memahami penggunaan e-filling yaitu penyampaian SPT secara elektronik, karena dengan pelaporan secara sistem digital akan mempermudah wajib pajak dengan SPT dilakukan secara online dan real time. Pengabdian masyarakat ini menggunakan metode pemberdayaan dan sosialisasi dan pelatihan bagi para karyawan dan dosen juga dilakukan pendampingan. Hasil kegiatan ini membuktikan adanya perubahan pemahaman yang baik dan pengetahuan bagi peserta PPM, yang awalnya tidak mengerti menjadi mengerti mengenai kewajiban perpajakan bagi orang pribadi dimulai dari menghitung, mengisi SPT sampai dengan melaporkannya melalui e-filling.
Optimasi Produksi Kompos Dari Limbah Organik Dengan Cara Fermentasi Menggunakan EM4
Authors: Hartati Tri Mulya , Ladjinga Erwin , Robo Sarif , Aji Krishna , Tangge Nurul Ainun 
Published: September 2023

Meningkatnya permintaan masyarakat akan sayuran mendorong petani untuk meningkatkan produksinya. Upaya yang dapat dilakukan untuk meningkatkan hasil panen antara lain penggunaan pupuk. Pemupukan dengan pupuk kimia merupakan alternatif yang sering dilakukan, namun kelangkaan pupuk kimia di pasaran membuat pupuk tersebut semakin mahal, sehingga perlu dicari alternatifnya. Pembuatan pupuk organik dari limbah tanaman merupakan salah satu alternatif yang memungkinkan, dengan teknologi EM yang akan mempercepat proses produksi pupuk. Kegiatan pengabdian ini dilaksanakan di Kelurahan Kalumata Kota Ternate Selatan dengan tujuan membantu petani mengelola limbah pertaniannya dengan memanfaatkannya sebagai pupuk organik. Peserta pengabdian adalah anggota Kelompok Petani Sayur "Masure". Metode yang digunakan adalah metode penyuluhan dan demonstrasi. Kegiatan dilakukan secara langsung dengan anggota kelompok tani, diawal dan diakhir kegiatan dilakukan penilaian untuk mengetahui tingkat pengetahuan peserta pengabdian. Hasil evaluasi menunjukkan bahwa pengetahuan dan pemahaman anggota kelompok tani “Masure” mengalami peningkatan. Hal ini tercermin dari peningkatan nilai tes akhir, dimana sebagian besar anggota mendapat nilai di atas 80. Peserta dalam kegiatan ini juga dapat memproduksi pupuk organik sendiri dengan memanfaatkan limbah organik dari sisa tanaman pasca panen dan kulit buah.
Pelatihan Desain Interior Berbasis Android bagi Masyarakat Kelurahan Potrobangsan, Kota Magelang
Authors: Murtopo Ali , Prawenti Herlita , Jannah Ria Miftakhul 
Published: September 2023

Salah satu profesi masyarakat Kelurahan Potrobangsan, Kota Magelang adalah pekerja bangunan. Ketrampilan dasar yang dikuasai adalah sebagai pembantu tukang, tukang kayu bangunan dan tukang batu bangunan. Apabila ingin membuka usaha sendiri, ketrampilan yang dipunyai akan dirasa kurang. Salah satu ketrampilan yang dapat dipunya untuk membuka usaha sendiri adalah ketrampilan desain dan pembuatan interior modern. Kelurahan Potrobangsan berada di Kota Magelang sehingga mendukung usaha ini. Hal ini dikarenakan masyarakat perkotaan saat ini telah mulai melirik arsitektur interior yang menarik. Desain interior dilakukan pada ruang tamu, kamar tidur, dapur, dan ruang lainya. Melalui penambahan backdrop, partisi, kitchen set ruang-ruang tersebut akan terlihat jauh lebih indah. Kondisi ini menjadi sala satu jalan wirausaha bagi pekerja banguan dan karangtaruna di Kelurahan Potrobangsan yang sebelumnya bekerja sebagai karyawan lepas. Dengan adanya pelatihan ini diharapkan masyarakat terutama pekerja bangunan dan karang taruna dapat mempunyai ketrampilan untuk membuka usaha (berwirausaha) dan dapat meningkatkan kualitas hidup.
Design, synthesis, and unraveling the antibacterial and antibiofilm potential of 2-azidobenzothiazoles: insights from a comprehensive in vitro study
Authors: Qadir Tanzeela , Kanth Saadat A. , Aasif Mohammad , Fadul Abdalla N. , Yatoo Gulam N. , Jangid Kailash , Mir Mushtaq A. , Shah Wajahat A. , Sharma Praveen K. 
Published: September 2023

The present study reports the synthesis of 2-azidobenzothiazoles from substituted 2-aminobenzothiazoles using sodium nitrite and sodium azide under mild conditions. All the synthesized compounds were examined for their antibacterial activity against Gram (+) bacteria, Staphylococcus aureus (ATCC 25923), Enterococcus faecalis (ATCC 51299), Bacillus cereus (ATCC 10876) and Gram (−) bacteria, Escherichia coli (ATCC 10536), Pseudomonas aeruginosa (ATCC 10145), Klebsiella pneumonia (ATCC BAA-2146)and clinical isolates of Gram (+) Methicillin Resistant S. aureus (MRSA) and Multi Drug Resistant E. coli. The Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) values by broth dilution method revealed that compound 2d exhibited significant antibacterial potential against E. faecalis and S. aureus with MIC of 8 μg/mL, while other synthesized compounds had only moderate effects against all the tested species. The compound significantly inhibited the biofilm formation of the bacterial strains below its MIC. The selective cytotoxicity of Compound 2d towards bacterial cells was evidenced on extended exposure of Human Embryonic Kidney-293 cell line to higher concentrations of the compound. Hence, the present study confirmed that compound 2d can be a potential drug candidate for future development as an antibacterial drug.
Linear site-response characteristics at central and eastern U.S. seismic stations
Authors: Carpenter N. Seth , Wang Zhenming , Woolery Edward W. 
Published: September 2023

Earthquake S waves can become trapped, or resonate, between the free surface and high-impedance basal layers, strongly contributing to site response at specific frequencies. Strong S-wave resonances have been observed in the central and eastern U.S., where many sites sit on unlithified sediments underlain by stiff bedrock. To evaluate S-wave resonances in this region, we calculated 1D linear site-responses at 89 seismic stations with developed S-wave velocity profiles into bedrock. We found that S-wave resonances at the fundamental and strongest (peak) modes occur across large ranges of frequencies, each spanning more than two orders of magnitude — 0.21–54.0 Hz and 0.29–71.5 Hz, respectively. Amplifications of ∼5 and ∼6 are common at the fundamental frequency and peak modes, respectively; the largest amplification calculated was 13.2. Using simple regression analyses, we evaluated the skills of six proxies derived from the S-wave velocity profiles to predict the frequencies and corresponding amplifications of the fundamental and peak modes. We found that the depths to the 1.0 km/s and 2.5 km/s horizons, consistent with other studies, and to the maximum impedance contrasts strongly correlate with the resonance frequencies and that the fundamental-mode and peak amplifications correlate with the maximum impedance ratios. Correlations improved for data subsets based on the number and magnitude of impedance ratios underlying the sites and are the strongest at sites underlain by a single impedance ratio of 3.0 or greater. Finally, we calculated the S-wave horizontal-to-vertical spectral ratios (HVSR) at each possible seismic station and found, consistent with other studies, that the first peak can be used to estimate fundamental-mode frequencies and the corresponding amplifications. Thus, S-wave HVSR, can provide useful estimates of the fundamental-mode linear site response parameters at sites lacking S-wave velocity profiles. Furthermore, S-wave HVSR curves appear to be useful to broadly categorize impedance-ratio profiles.
A study on the appropriate dose of rocuronium for intraoperative neuromonitoring in Da Vinci robot thyroid surgery: a randomized, double-blind, controlled trial
Authors: Lan Jianning , Huang Qijian , Su Jiansheng , Zhang Xuru , Zhang Liangcheng 
Published: September 2023

BackgroundThis study was to explore the effect of different doses of rocuronium bromide on neuromonitoring during Da Vinci robot thyroid surgery.MethodsThis was a prospective, randomized, double-blind, controlled trial that included 189 patients who underwent Da Vinci robot thyroidectomy with intraoperative neuromonitoring(IONM). Patients were randomly divided into three groups and given three different doses of rocuronium (0.3mg/kg, 0.6mg/kg, 0.9mg/kg). Outcome measurements included IONM evoked potential, postoperative Voice Handicap Index-30(VHI-30), intraoperative body movement incidence rate, Cooper score, and hemodynamic changes during anesthesia induction.Results: The difference in IONM evoked potentials at various time points between the three groups was not statistically significant (P&gt;0.05). The difference in Cooper scores and intraoperative body movement incidence rate between 0.6 and 0.9mg/kg groups was statistically significant compared with the 0.3mg/kg group (both P&lt;0.001). There was no statistically significant difference in VHI-30 score and hemodynamic changes during anesthesia induction among the three groups (both P&gt;0.05).ConclusionsFor patients undergoing Da Vinci robot thyroidectomy, a single dose of rocuronium at 0.6 and 0.9mg/kg during anesthesia induction can provide stable IONM evoked potential. Additionally, compared to 0.3 mg/kg, it can offer better tracheal intubation conditions and lower incidence of body movements during surgery. It is worth noting that the use of higher doses of rocuronium should be adjusted based on the duration of IONM and local practices.
Spatiotemporal evolution and multi-scenario prediction of habitat quality in the Yellow River Basin
Authors: Chen Yanglong , He Zhilin , Yue Tianming , Mu Weichen , Qin Fen 
Published: September 2023

IntroductionThe Yellow River Basin (YRB) is not only a vital area for maintaining ecological security but also a key area for China’s economic and social development. Understanding its land-use change trends and habitat quality change patterns is essential for regional ecological conservation and effective resource allocation.MethodsThis study used the patch-generating land-use simulation (PLUS) and Integrated Valuation of Ecosystem Services and Trade-offs (InVEST) models to analyze and predict the spatial and temporal trends of habitat quality in the YRB from 2000 to 2030 under natural development (ND) and ecological conservation and high-quality development (ECD) scenarios. The PLUS model was used to predict land-use change in 2030 under different scenarios, after which the InVEST model was used to obtain the habitat quality distribution characteristics from the 2000–2030 period.Results(1) The mean values of habitat quality in the YRB in 2000, 2010, and 2020 were 0.6849, 0.6992, and 0.7001, respectively. The mean habitat quality values were moderately high. Spatial distribution characteristics were high in the west and low in the east and along the water. In 2030, habitat quality (0.6993) started to decline under ND, whereas under ECD, there was an indication of substantial improvement in habitat quality (0.7186). (2) The mean habitat degradation values in 2000, 2010, and 2020 were 0.0223, 0.0219, and 0.0231, respectively. The level of habitat degradation showed a decreasing trend, followed by an increasing trend with a stable spatial distribution pattern. The mean level of habitat degradation in 2030 (0.0241) continued to increase under ND, while a substantial decrease in the level of habitat degradation occurred under ECD (0.0214), suggesting that the level of habitat degradation could be effectively contained under the ECD scenario. (3) During the study period, the conversion of building land—both negative and positive—had the most pronounced impact on habitat quality per unit area. Further, the conversion of grassland was shown to be a key land transformation that may either lead to the deterioration or improvement of the ecological environment. The results provide scientifific theoretical support and a decision basis for ecological conservation and the high-quality development of the YRB.
Continuous joint velocity estimation using CNN-based deep learning for multi-DoF prosthetic wrist for activities of daily living
Authors: Meng Zixia , Kang Jiyeon 
Published: September 2023

IntroductionMyoelectric control of prostheses is a long-established technique, using surface electromyography (sEMG) to detect user intention and perform subsequent mechanical actions. Most machine learning models utilized in control systems are trained using isolated movements that do not reflect the natural movements occurring during daily activities. Moreover, movements are often affected by arm postures, the duration of activities, and personal habits. It is crucial to have a control system for multi-degree-of-freedom (DoF) prosthetic arms that is trained using sEMG data collected from activities of daily living (ADL) tasks.MethodThis work focuses on two major functional wrist movements: pronation-supination and dart-throwing movement (DTM), and introduces a new wrist control system that directly maps sEMG signals to the joint velocities of the multi-DoF wrist. Additionally, a specific training strategy (Quick training) is proposed that enables the controller to be applied to new subjects and handle situations where sensors may displace during daily living, muscles can become fatigued, or sensors can become contaminated (e.g., due to sweat). The prosthetic wrist controller is designed based on data from 24 participants and its performance is evaluated using the Root Mean Square Error (RMSE) and Pearson Correlation.ResultThe results are found to depend on the characteristics of the tasks. For example, tasks with dart-throwing motion show smaller RSME values (Hammer: 6.68 deg/s and Cup: 7.92 deg/s) compared to tasks with pronation-supination (Bulb: 43.98 deg/s and Screw: 53.64 deg/s). The proposed control technique utilizing Quick training demonstrates a decrease in the average root mean square error (RMSE) value by 35% and an increase in the average Pearson correlation value by 40% across all four ADL tasks.
Interpretable machine learning for prediction of clinical outcomes in acute ischemic stroke
Authors: Lee Joonwon , Park Kang Min , Park Seongho 
Published: September 2023

Background and aimsPredicting the prognosis of acute ischemic stroke (AIS) is crucial in a clinical setting for establishing suitable treatment plans. This study aimed to develop and validate a machine learning (ML) model that predicts the functional outcome of AIS patients and provides interpretable insights.MethodsWe included AIS patients from a multicenter stroke registry in this prognostic study. ML-based methods were utilized to predict 3-month functional outcomes, which were categorized as either favorable [modified Rankin Scale (mRS) ≤ 2] or unfavorable (mRS ≥ 3). The SHapley Additive exPlanations (SHAP) method was employed to identify significant features and interpret their contributions to the predictions of the model.ResultsThe dataset comprised a derivation set of 3,687 patients and two external validation sets totaling 250 and 110 patients each. Among them, the number of unfavorable outcomes was 1,123 (30.4%) in the derivation set, and 93 (37.2%) and 32 (29.1%) in external sets A and B, respectively. Among the ML models used, the eXtreme Gradient Boosting model demonstrated the best performance. It achieved an area under the receiver operating characteristic curve (AUC-ROC) of 0.790 (95% CI: 0.775–0.806) on the internal test set and 0.791 (95% CI: 0.733–0.848) and 0.873 (95% CI: 0.798–0.948) on the two external test sets, respectively. The key features for predicting functional outcomes were the initial NIHSS, early neurologic deterioration (END), age, and white blood cell count. The END displayed noticeable interactions with several other features.ConclusionML algorithms demonstrated proficient prediction for the 3-month functional outcome in AIS patients. With the aid of the SHAP method, we can attain an in-depth understanding of how critical features contribute to model predictions and how changes in these features influence such predictions.
Stimulation of peroneal nerves reveals maintained somatosensory representation in transtibial amputees
Authors: Ritter Caroline , Geisler Maria , Blume Kathrin R. , Nehrdich Sandra , Hofmann Gunther O. , Koehler Hanna , Miltner Wolfgang H. R. , Weiss Thomas 
Published: September 2023

IntroductionSeveral studies have found changes in the organization of the primary somatosensory cortex (SI) after amputation. This SI reorganization was mainly investigated by stimulating neighboring areas to amputation. Unexpectedly, the somatosensory representation of the deafferented limb has rarely been directly tested.MethodsWe stimulated the truncated peroneal nerve in 24 unilateral transtibial amputees and 15 healthy controls. The stimulation intensity was adjusted to make the elicited percept comparable between both stimulation sides. Neural sources of the somatosensory-evoked magnetic fields (SEFs) to peroneal stimulation were localized in the contralateral foot/leg areas of SI in 19 patients and 14 healthy controls.ResultsWe demonstrated the activation of functionally preserved cortical representations of amputated lower limbs. None of the patients reported evoked phantom limb pain (PLP) during stimulation. Stimulation that evoked perceptions in the foot required stronger intensities on the amputated side than on the intact side. In addition to this, stronger stimulation intensities were required for amputees than for healthy controls. Exploratorily, PLP intensity was neither associated with stimulation intensity nor dipole strength nor with differences in Euclidean distances (between SEF sources of the healthy peroneus and mirrored SEF sources of the truncated peroneus).DiscussionOur results provide hope that the truncated nerve may be used to establish both motor control and somatosensory feedback via the nerve trunk when a permanently functional connection between the nerve trunk and the prosthesis becomes available.
Rationale and protocol of a double-blind, randomized, placebo-controlled trial to test the efficacy, safety, and tolerability of dimethyl fumarate in Friedreich Ataxia (DMF-FA-201)
Authors: Pane Chiara , Marra Alberto Maria , Aliberti Ludovica , Campanile Mario , Coscetta Federica , Crisci Giulia , D'Assante Roberta , Marsili Angela , Puorro Giorgia , Salzano Andrea , Cittadini Antonio , Saccà Francesco 
Published: September 2023

IntroductionFriedreich Ataxia (FRDA) is an autosomal recessive neurodegenerative disorder that causes gait and limb ataxia, dysarthria, and impaired vibratory sense, with cardiomyopathy being the predominant cause of death. There is no approved therapy, which results in the use of symptomatic treatments and the chronic support of physiotherapy. Dimethyl fumarate (DMF) is a fumaric acid ester used for the treatment of psoriasis and Multiple Sclerosis (MS). It induces Nrf2 in vitro and in vivo, and it increases frataxin in FRDA patient lymphoblasts, in mouse models, and in MS treated patients.MethodsThe aim of our study is to investigate if DMF can increase the expression of the FXN gene and frataxin protein and ameliorate in-vivo detectable measures of mitochondrial dysfunction in FRDA. The study is composed of a screening visit and two sequential 12-week phases: a core phase and an extension phase. During the first phase (core), patients will be randomly assigned to either the DMF or a placebo group in a 1:1 ratio. During the first week, patients will receive a total daily dose of 240 mg of DMF or placebo; from the second week of treatment, the dose will be increased to two 120 mg tablets BID for a total daily dose of 480 mg. During the second phase (extension), all patients will be treated with DMF. EudraCT number 2021-006274-23.EndpointsThe primary endpoint will be a change in FXN gene expression level after 12 weeks of treatment. Secondary endpoints will be frataxin protein level, cardiopulmonary exercise test outputs, echocardiographic measures, Nrf2 pathway and mitochondrial biogenesis gene expression, safety, clinical scales, and quality of life scales.ConclusionsThis is the first study aimed at exploring the ability of DMF, an already available treatment for MS and psoriasis, to correct the biological deficits of FRDA and potentially improve mitochondrial respiration in-vivo.
Assessment of body composition in adults hospitalized with acute COVID-19: a scoping review
Authors: das Virgens Isabel Pinto Amorim , Sousa Iasmin Matias , Bezerra Agnes Denise Lima , Fayh Ana Paula Trussardi 
Published: September 2023

IntroductionBody composition (BC) assessment can supply accurate information for in-hospital nutritional evaluation. The aim of this study was to explore in the literature how the studies assessed BC, for what purpose, and investigate the role of BC findings in COVID-19 hospitalized patients’ outcomes.MethodsA scoping review was conducted according to the methodology available on the Joanna Briggs Institute website. We used the PCC acronym for the systematic search (population: adults with COVID-19, concept: assessment of BC, context: hospital setting) and performed it on PubMed, Scopus, and the Web of Science on 16 September 2022. Eligibility criteria consisted of the utilization of BC assessment tools in COVID-19 patients. Studies in which BC was solely measured with anthropometry (perimeters and skinfolds) were excluded. No language restriction was applied.ResultsFifty-five studies were eligible for the review. Out of the 55 studies, 36 used computed tomography (CT), 13 used bioelectrical impedance (BIA), and 6 used ultrasound (US). No studies with D3-creatinine, 24  h urine excretion, dual-energy X-ray absorptiometry, or magnetic resonance were retrieved. BC was mainly assessed to test associations with adverse outcomes such as disease severity and mortality.DiscussionStudies assessing BC in hospitalized patients with COVID-19 used mainly CT and BIA and associated the parameters with severity and mortality. There is little evidence of BC being assessed by other methods, as well as studies on BC changes during hospitalization.