bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neuropathies related to hepatitis E virus infection: A prospective, matched case–control study
Authors: Ripellino Paolo , Lascano Agustina Maria , Scheidegger Olivier , Schilg‐Hafer Lenka , Schreiner Bettina , Tsouni Pinelopi , Vicino Alex , Peyer Anne‐Kathrin , Humm Andrea Monika , Décard Bernhard Friedrich , Pianezzi Enea , Zezza Giulia , Sparasci Davide , Hundsberger Thomas , Dietmann Anelia , Jung Hans , Kuntzer Thierry , Wilder‐Smith Einar , Martinetti‐Lucchini Gladys , Petrini Orlando , Fontana Stefano , Gowland Peter , Niederhauser Christoph , Gobbi Claudio 
Published: August 2023

AbstractBackgroundAcute hepatitis E virus (HEV) infection has recently emerged as a potential trigger for acute dysimmune neuropathies, but prospective controlled studies are lacking.AimsTo compare the frequency of concomitant acute HEV infection in patients with neuralgic amyotrophy (NA), Guillain–Barré syndrome (GBS), and Bell's palsy with a matched control population.MethodsSwiss multicenter, prospective, observational, matched case–control study over 3 years (September 2019–October 2022). Neurological cases with NA, GBS, or Bell's palsy were recruited within 1 month of disease onset. Healthy controls were matched for age, sex, geographical location, and timing of blood collection. Diagnostic criteria for acute hepatitis E were reactive serum anti‐HEV IgM and IgG assays (ELISA test) and/or HEV RNA detection in serum by real‐time polymerase chain reaction (RT‐PCR). RT‐PCR was performed on sera to confirm IgM positivity.ResultsWe included 180 patients (59 GBS, 51 NA, 70 Bell's palsy cases) and corresponding matched controls (blood donors) with median age 51 years for both groups and equal gender distribution. Six IgM+ cases were detected in the NA, two in the GBS, and none in the Bell's palsy group. Two controls were anti‐HEV IgM‐positive. At disease onset, most cases with acute HEV infection had increased liver enzymes. A moderate association (p = 0.027, Fisher's exact test; Cramér's V = −0.25) was observed only between acute HEV infection and NA.ConclusionThis prospective observational study suggests an association between concomitant acute HEV infection and NA, but not with GBS or Bell's palsy.
Psychological and cognitive factors involved in decision‐making process of haemophilia carriers in reproductive choices
Authors: Cutica Ilaria , Mortarino Mimosa , Garagiola Isabella , Pravettoni Gabriella , Peyvandi Flora 
Published: August 2023

AbstractIntroductionHaemophilia carriers (HCs) face a multitude of psychological challenges, mainly linked to the possibility of having an affected child. Important reproductive decisions such as opting for pre‐implantation genetic testing, or choosing prenatal diagnosis and then whether to continue or interrupt pregnancy in case of affected male fetus, have to be taken into consideration. Notwithstanding, the role of psychological characteristics on such decision‐making process needs further investigation.AimThe aim of this study was to investigate whether HCs’ beliefs and emotions about haemophilia and cognitive factors such as decision‐making style, risk perception, coping strategies in response to stress, and need for cognitive closure might modulate HCs’ reproductive decisions.MethodsParticipants were interviewed about their beliefs and emotions on haemophilia and filled an on‐line standardized questionnaire on cognitive variables. Sixty HCs participated in this study.ResultsResults show that HCs with high distress for haemophilia given by negative childhood experiences for one or more family member illness and by high concern for their children's health, and with psychological traits characterized by logical (versus emotional) reasoning, active coping style and high need for certainty, tend to choose diagnostic prenatal tests over routine pregnancy analysis.ConclusionThis study highlighted the influence of negative early‐life experience with haemophilia and of several cognitive factors in HCs choice of prenatal test.
High mortality of beetle migrants along the Eastern Mediterranean Flyway
Authors: Hawkes Will L. , Özden Özge , Forster Olivia , Walliker Teddy , Lacey Katharine , Gao Boya , Chapman Jason W. , Wotton Karl R. 
Published: August 2023

Abstract
Migration is costly in terms of increased energy expenditure and exposure to risks encountered en route. These factors can lead to a higher mortality among migrants compared with more sedentary life history stages.
Insect migrants are incredibly numerous, but as they are less conspicuous than vertebrate migrants and as migration often occurs at high altitude and over a broad front, it can be difficult to study migration‐related mortality. A major source of information on migration‐related mortality comes from cadavers found on the strandline following unsuccessful sea crossings.
Here, we analyse strandline mortality following a 100 km crossing of open ocean along the Eastern Mediterranean Flyway from the Middle East mainland to the island of Cyprus by tens of millions of insects.
All strandline recordings were of two species of beetles, the seven‐spot ladybird Coccinella septempunctata and the carabid beetle Calosoma olivieri, whereas only nine individuals of C. septempunctata were caught successfully arriving with the rest of the insect assemblage over the ocean.
Major strandings were associated with easterly winds, suggesting origins from the Middle East mainland, with the individuals documented as extremely weak and unable to fly or dead.
Our results suggest that beetles are weaker migrants than other members of the migratory insect assemblage, with the sea crossing too far for the great majority to fly, leading to high mortality. The impact of this high mortality on the marine ecosystems is discussed.
Follow the policy: An actor network theory study of widening participation to medicine in two countries
Authors: Coyle Maeve , Bullen Jonathan , Poobalan Amudha , Sandover Sally , Cleland Jennifer 
Published: August 2023

AbstractIntroductionThe slow pace of change in respect of increasing the diversity of medical students suggests powerful actors are reproducing practices to support the status quo. Opening up medicine to embrace diversity thus requires the deconstruction of entrenched processes and practices. The first step in doing so is to understand how the actor‐network of widening participation and access to medicine (WP/WA) is constructed. Thus, here we examine how the connections among actors in WP/WA in two different networks are assembled.MethodsA comparative case study using documents (n = 7) and interviews with staff and students (n = 45) from two medical schools, one United Kingdom and one Australian, was used. We used Callon's moments of translation (problematisation, interessement/operationalisation, enrolment, mobilisation) to map the network of actors as they are assembled in relation to one another. Our main actant was institutional WP to medicine policy (actor‐as‐policy).ResultsOur actor‐as‐policy introduced five other actors: the medical school, medical profession, high schools, applicants and medical school staff. In terms of problematisation, academic excellence holds firm as the obligatory passage point and focal challenge for all actors in both countries. The networks are operationalised via activities such as outreach and admissions policy (e.g., affirmative action is apparent in Australia but not the UK). High schools play (at best) a passive role, but directed by the policy, the medical schools and applicants work hard to achieve WP/WA to medicine. In both contexts, staff are key mobilisers of WP/WA, but with little guidance in how to enact policy. In Australia, policy drivers plus associated entry structures mean the medical profession exerts significant influence.ConclusionsKeeping academic excellence as the obligatory passage point to medical school shapes the whole network of WP/WA and perpetuates inequality. Only by addressing this can the network reconfigure.
The Problem of Early Islamic Diversity in Anatolia: Rethinking Dervish Piety Through Pantheistic Ideas
Authors: Ay Resul 
Published: August 2023

AbstractThe Islamic diversity that developed parallel to the Islamization of Anatolia from roughly the 12th century onwards and was called dervish religiosity, is often defined by its inattentive and indifferent attitude toward Shari‘a, although some of its other features are mentioned more or less. However, in this dervish‐based religiosity, it draws attention that both the perception of Shari‘a and some other religiosity practices are more related to the tawhid beliefs in pantheistic sense. This paper aims to analyze how both dervish religiosity and folk religiosity, which developed largely under its influence, are shaped through some mystical thoughts and spiritual experiences such as ‘identification with God’, ‘immanence of God in man’ and ‘the human divinity’. The folk piety, which appears to be shaped within the framework of faith in saints, including high respect and various types of veneration that neglect the norms of Islamic worship, will be seen in relation to the pantheistic thoughts, as reflected in the understanding of seeing man as the qibla.
Genetic research of inherited peripheral neuropathies
Authors: Higuchi Yujiro 
Published: August 2023

AbstractBackgroundOur department has been conducting genetic research on hereditary neuropathies, with a focus on the Charcot–Marie–Tooth (CMT) disease and other inherited peripheral neuropathies for the past 20 years. The CMT disease is an untreatable disease characterized by progressive muscle weakness, atrophy, and sensory impairment, primarily affecting the peripheral nerves.Materials and MethodsIn our institution, we collected blood samples from patients with the CMT disease, nationwide, and performed comprehensive genetic testing to elucidate its underlying causes.ResultUsing next‐generation sequencing (NGS), we successfully discovered two novel causative genes of the CMT disease, membrane metalloendopeptidase (MME), and cytochrome c oxidase assembly factor 7, via whole exome analysis of previously unidentified cases. These findings, combined with the comprehensive analysis enabled by NGS, have significantly improved the diagnostic rate of this disease.ConclusionNotably, the MME gene has been reported as the most frequent causative gene for autosomal recessive CMT disease, attracting global attention and subsequent research efforts. Accurate genetic diagnosis for each patient serves as a crucial first step toward understanding hereditary diseases. The identification of new causes of the CMT disease can assist in elucidating the molecular mechanisms involved completely, further contributing to the development of effective treatment approaches, including gene therapies.
Taiwan renal data report system: Framework, function, and development
Authors: Lin Ming‐Yen , Liao Chia‐Te , Lin Ming‐Huang , Wu Hsiao‐Ting , Wu Mai‐Szu , Hsu Yung‐Ho , Hsu Chih‐Cheng 
Published: August 2023

AbstractThe world healthcare system is actively seeking possible solutions for the rapid growth of kidney disease threats. The Taiwan Renal Data System (TWRDS) was central in assisting kidney health and care policymaking to reduce end‐stage kidney disease incidence and mortality. This article summarizes the TWRDS framework, recent applications, and developments to provide new insights for some international researchers to promote planetary kidney health. The TWRDS originated in 1987 for the accreditation and quality monitoring of dialysis units and was connected with enriched health claim databases after the implementation of universal national health insurance in Taiwan in 1995. As a healthcare information centre, TWRDS has published annual reports forming indispensable instructions for renal care improvement since 2014. The TWRDS possesses three main functions: (1) kidney disease surveillance; (2) offering rich materials for research purposes; (3) achieving precision prevention and care through complex algorithms. In the new era, TWRDS can help build a more resilient society against communicable disease threats by integrating remote sensor techniques for developing future remote healthcare structures, as well as identifying kidney health inequity populations and promoting healthcare resources distributed equity. The global healthcare system is facing escalating burdens of non‐communicable disease care due to the rapidly growing elderly population. Therefore, a considerable‐scale data system is an essential decision‐supportive tool in promoting an evidence‐based, resilient, sustainable, equity care environment. Undoubtedly, TWRDS experience is a practical example of leveraging healthcare providers' decisions, care outcomes, and renovation.
Intronic microRNA‐directed regulation of mitochondrial reactive oxygen species enhances plant stress tolerance in Arabidopsis
Authors: Xu Wei‐Bo , Zhao Lei , Liu Peng , Guo Qian‐Huan , Wu Chang‐Ai , Yang Guo‐Dong , Huang Jin‐Guang , Zhang Shu‐Xin , Guo Xing‐Qi , Zhang Shi‐Zhong , Zheng Cheng‐Chao , Yan Kang 
Published: August 2023

Summary
MicroRNAs (miRNAs) play crucial roles in regulating plant development and stress responses. However, the functions and mechanism of intronic miRNAs in plants are poorly understood.
This study reports a stress‐responsive RNA splicing mechanism for intronic miR400 production, whereby miR400 modulates reactive oxygen species (ROS) accumulation and improves plant tolerance by downregulating its target expression.
To monitor the intron splicing events, we used an intronic miR400 splicing‐dependent luciferase transgenic line. Luciferase activity was observed to decrease after high cadmium concentration treatment due to the retention of the miR400‐containing intron, which inhibited the production of mature miR400. Furthermore, we demonstrated that under Cd treatments, Pentatricopeptide Repeat Protein 1 (PPR1), the target of miR400, acts as a positive regulator by inducing ROS accumulation. Ppr1 mutation affected the Complex III activity in the electron transport chain and RNA editing of the mitochondrial gene ccmB.
This study illustrates intron splicing as a key step in intronic miR400 production and highlights the function of intronic miRNAs as a ‘signal transducer’ in enhancing plant stress tolerance.
Validation of a Wearable System for Lower Extremity Assessment
Authors: Zhang Haohua , Song Yang , Li Cheng , Dou Yong , Wang Dacheng , Wu Yinyue , Chen Xiaoyi , Liu Di 
Published: August 2023

ObjectiveRemote assessment and diagnosis of functional impairment caused by osteoarthritis (OA) of the knee can achieve early intervention of patients’ functional impairment, prevent the deterioration of OA of the knee, and provide functional remote screening for patients with knee OA. This study introduced an inertial measurement unit (IMU) sensor‐based system to assess lower extremity function and perform gait analysis. Then, we compared its accuracy to gold‐standard motion capture and gait measurement systems.MethodsNine adults were selected to participate in a comparative study of gait assessment outcomes using an IMU sensor‐based wearable system, a gold‐standard motion capture system, and a pressure‐based gait analysis system. The subject walked on a path that incorporated all three systems. Data analysis was performed on spatiotemporal gait parameters, including velocity, cycle time, cadence, and stride length. This was followed by gait phases, including stance, swing, double stance, and single limb support phases. Data were processed using the data processing software of each system. An independent sample t‐test was conducted for inter‐group comparison to analyze the data.ResultsThe spatiotemporal gait parameters of the systems demonstrated excellent consistency, and the gait phases showed high consistency. Compared to the gold‐standard pressure‐based gait analysis system (the GATERite system), the mean gait cycle time results were 1.124 s vs. 1.127 s (p = 0.404); cadence was 93.333 steps/min vs. 94.189 steps/min (p = 0.482); stance phase was 60.89% vs. 63.26% (p < 0.001); swing phase was 39.11% vs. 36.74% (p < 0.001); stride length was 1.404 m vs. 1.420 m (p = 0.743); speed was 1.093 m/s vs. 1.110 m/s (p = 0.725). Compared to the gold‐standard video‐based motion capture system, the root mean square error was 2.7° for the hip angle and 2.6° for the knee angle.ConclusionsThis IMU‐based wearable system delivered precise measuring results to evaluate patients with knee OA. This technology can also be used to guide rehabilitation exercises for patients with knee OA.
The role of individual‐ and interactive‐level relationship maintenance on married couples' commitment
Authors: Hu Yifan , Ogolsky Brian G. , Stafford Laura 
Published: August 2023

AbstractThe interaction of maintenance processes between partners constitutes a complex context, which can be categorized into individual‐ and interactive‐level relationship maintenance processes. Individual‐level maintenance processes refer to both partners' relationship maintenance enactment and perception of partners' relationship maintenance. Interactive‐level relationship maintenance processes include similarity, accuracy, and projection. This study investigated the actor and partner effects of individual and interactive relationship maintenance processes on commitment as moderated by relationship satisfaction. We recruited 193 mixed‐gender married couples from the midwestern US and adopted the two‐intercept actor‐partner interdependence model to analyze the data. The results demonstrated a positive association between husbands' relationship maintenance enactment and their commitment, a negative association between similarity of relationship maintenance enactment and wives' commitment, a positive association between husbands' accuracy and wives' commitment, and a negative association between husbands' projection and their commitment. Satisfaction was strongly associated with participants' commitment and moderated the association between relationship maintenance enactment and commitment for both partners, the association between husbands' maintenance enactment and wives' commitment, and the association between husbands' partner perception and their commitment. Satisfaction also moderated the association between wives' accuracy and husbands' commitment and the association between husbands' projection and both partners' commitment.
RALF‐like peptide improves the colonization of endophytic Colletotrichum tofieldiae through interacting with plant receptor‐like kinase
Authors: Liao Ye , Wen Xiangyu , Zheng Jingyuan , Li Xin , Deng Xuelei , Tan Xinqiu , Liang Xiuhui , Yi Xi , Liao Hongdong 
Published: August 2023

AbstractEndophytes can colonize a host plant without inducing obvious disease symptoms. Elicitors from endophytes may play important roles in balancing endophyte colonization. We identified a novel endophytic elicitor from Colletotrichum tofieldiae, CtRALF, that has structural and functional characteristics similar to those of rapid alkalinization factor (RALF) peptides in Arabidopsis thaliana. We found that CtRALF can directly interact with the host plant receptor‐like kinase FERONIA (FER). The colonization of FER mutant plants by hyphae of C. tofieldiae was obviously reduced compared with that on wild‐type plants. Furthermore, the interaction of CtRALF with FER regulated symbiotic signals by triggering calcium waves, inhibiting reactive oxygen species bursts, increasing mitogen‐activated protein kinase phosphorylation and reducing the stabilization of MYC2. Collectively, these results suggested that the RALF homologue of endophytes may improve their symbiosis by interacting with host plant‐encoded FER.
Short‐term preservation of canine sperm‐binding ability and other metrics using the INRA‐96 in comparison to Tris‐egg yolk extender
Authors: Cavalcanti Thales Pinheiro , Pereira Ana Glória , Bezerra Luana Grasiele Pereira , Moreira Samara Sandy Jerônimo , da Silva Andreia Maria , Matos Yuri Gonçalves , Jorge‐Neto Pedro Nacib , Silva Alexandre Rodrigues 
Published: August 2023

AbstractThe use of assisted reproductive techniques, such as chilled semen, contributes to the maintenance and genetic improvement of canine breeding. The INRA‐96 extender is a commercially available, chemically defined medium that was initially developed for the preservation of equine semen and exhibits preservation potential in the canine species. This research aims to evaluate the INRA‐96 extender as an alternative for the short‐term preservation of canine semen in terms of sperm quality parameters such as motility and kinetic parameters, integrity and functionality of the plasma membrane in fresh and chilled–rewarmed samples, as well as the sperm‐binding ability using the perivitelline membrane of the chicken egg as an indicator of the fertilizing capacity of the preserved semen. A total of 18 ejaculates from 9 French bulldogs (two ejaculates per dog) were collected and divided into two aliquots that were diluted in Tris‐egg yolk 20% (control) or INRA‐96 to a final concentration of 100 × 106 sperm/mL. Samples were refrigerated in a biological incubator at 5°C and evaluated at 0, 24 and 48 h time points. Comparing the two treatments after 48 h of refrigeration, both extenders showed similar values (p < .5) for the majority of kinetic parameters, with the INRA‐96 group promoting a total motility of 88.1 ± 2.9%. In addition, the morphology, integrity and functionality of the plasma membrane were preserved above 70% in this group. Dilution with INRA‐96 also provided a significantly higher amount of sperm bound (256.2 ± 21.1) to the perivitelline membrane of the egg yolk compared to the sperm‐binding rates (p < .05) achieved at the use of Tris‐egg yolk (215.2 ± 21 bound spermatozoa) at 48 h. Our study proved similar functional properties of dog sperm cells treated with INRA‐96 in comparison to commonly used home‐made Tris‐based extender during short‐time storage.
On the perimeter estimation of pixelated excursion sets of two‐dimensional anisotropic random fields
Authors: Cotsakis Ryan , Di Bernardino Elena , Opitz Thomas 
Published: August 2023

AbstractWe are interested in creating statistical methods to provide informative summaries of random fields through the geometry of their excursion sets. To this end, we introduce an estimator for the length of the perimeter of excursion sets of random fields on observed over regular square tilings. The proposed estimator acts on the empirically accessible binary digital images of the excursion regions and computes the length of a piecewise linear approximation of the excursion boundary. The estimator is shown to be consistent as the pixel size decreases, without the need of any normalization constant, and with neither assumption of Gaussianity nor isotropy imposed on the underlying random field. In this general framework, even when the domain grows to cover , the estimation error is shown to be of smaller order than the side length of the domain. For affine, strongly mixing random fields, this translates to a multivariate Central Limit Theorem for our estimator when multiple levels are considered simultaneously. Finally, we conduct several numerical studies to investigate statistical properties of the proposed estimator in the finite‐sample data setting.