bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimization of workflow for detection of brain metastases at 3T: is a black-blood MTC prepared 3D T1 used alone robust enough to replace the combination of conventional 3D T1 and the black-blood 3D T1 MTC?
Authors: Chkili Sophia , Lefebvre Yolène , Chao Shih-Li , Bali Maria Antonietta , Lemort Marc , Coquelet Nicolas 
Published: March 2023

Abstract
Purpose
Sampling perfection with application-optimized contrasts by using different flip angle evolutions (SPACE) is a black-blood 3D T1-weighted (T1w) magnetic resonance imaging (MRI) sequence that has shown robust performance for brain metastases detection. However, this could generate false positive results due to suboptimal blood signal suppression. For that reason, SPACE is used in our institution alongside a non-black-blood T1w sequence: volumetric interpolated breath-hold examination (VIBE). Our study aims to (i) evaluate the diagnostic accuracy of SPACE compared to its use in combination with VIBE, (ii) investigate the effect of radiologist’s experience in the sequence’s performance, and (iii) analyze causes of discordants results.

Methods
Four hundred seventy-three 3T MRI scans were retrospectively analyzed following a monocentric study design. Two studies were formed: one including SPACE alone and one combining both sequences (SPACE + VIBE, the reference). An experienced neuroradiologist and a radiology trainee independently reviewed the images of each study and reported the number of brain metastases. The sensitivity (Se) and specificity (Sp) of SPACE compared to SPACE + VIBE in metastases detection were reported. Diagnostic accuracy of SPACE compared to SPACE + VIBE was assessed by using McNemar’s test. Significance was set at p < 0.05. Cohen’s kappa was used for inter-method and inter-observer variability.

Results
No significant difference was found between the two methods, with SPACE having a Se > 93% and a Sp > 87%. No effect of readers’ experience was disclosed.

Conclusion
Independently of radiologist’s experience, SPACE alone is robust enough to replace SPACE + VIBE for brain metastases detection.
The role of serotonin in modulating common waxbill behaviour
Authors: Saldanha Beatriz C. , Silva Paulo A. , Maximino Caio , Cardoso Gonçalo C. , Trigo Sandra , Soares Marta C. 
Published: March 2023

AbstractSerotonin or 5-hydroxytryptamine (5-HT) is a monoaminergic neurotransmitter that is known to influence behaviour in various animal species. Its actions, however, are complex and not well-understood yet. Here, we tested whether and how two 5-HT receptor agonists and a 5-HT receptor antagonist influence behaviour in common waxbills (Estrilda astrild), focusing on aggression, movement and feeding. We applied acute administration of either 8-OH-DPAT (a 5-HT1Areceptor agonist), fluoxetine (a selective serotonin reuptake inhibitor; SSRI) or WAY 100,635 (a 5-HT1Areceptor antagonist), and then quantified behaviour in the context of competition for food. Waxbills treated with the SSRI fluoxetine showed an overall decrease of aggressive behaviour, activity and feeding, while we found no significant effects of treatment with the other serotonergic enhancer (8-OH-DPAT) or with the antagonist WAY 100,635. Since both 8-OH-DPAT and WAY 100,635 act mainly on 5-HT1Areceptor pathways, while fluoxetine more generally affects 5-HT pathways, our results suggest that receptors other than 5-HT1Aare important for serotonergic modulation of waxbill behaviour.Significance statementThe serotonergic system is of interest for current behavioural research due to its influence on a range of behaviours, including aggression, affiliative behaviour, feeding and locomotion in various species. There are, however, numerous discrepancies regarding the behavioural effects of serotonin across studies. We used acute pharmacological manipulations of the serotonergic system in common waxbills, using two serotonin enhancers (8-OH-DPAT and fluoxetine) and a serotonin blocker (WAY 100,635). Behavioural effects of these pharmacological manipulations on aggressiveness, movement and feeding, during tests of competition over food, indicated an anxiogenic-like effect of fluoxetine, but not of 8-OH-DPAT and WAY 100,635. This suggests a distinct role for different serotonergic pathways on waxbill behaviour.
The Efficacy of VAMMFT Compared to “Bogota Bag” in Achieving Sheath Closure Following Temporary Abdominal Closure at Index Laparotomy for Trauma
Authors: Pillay Pavalini , Smith Michelle T. D. , Bruce John L. , Clarke Damian L. , Bekker Wanda 
Published: March 2023

AbstractIntroductionThe open abdomen (OA) is a necessary component of damage control surgery and closure is often challenging. Our aim was to review our ten‐year experience with OA in trauma patients and to compare the success of a dual closure technique termed vacuum‐assisted, mesh‐mediated fascial traction (VAMMFT) to an exclusively Bogota Bag (BB) approach.MethodsA retrospective analysis was performed using the HEMR database from 2012 to 2022, comparing demographics, mechanism of injury, admission vitals and biochemistry between patients with BB and VAMMFT applications. Rate of secondary abdominal closure and complications were assessed in both groups. Logistic regression was used to find predictors of closure.ResultsOA was required by 348 patients at index laparotomy. Of these, 133 (38.2%) were managed with VAMMFT and 215 (61.8%) exclusively with a BB. There were no statistical differences between the BB and VAMMFT groups in terms of demographics, injuries, admission vitals and biochemistry. The VAMMFT group achieved a closure rate of 73% compared to 54.9% in the BB group (OR of 2.2 [1.4–3.7]). There was no significant difference in fistulation rate between the two groups (p = 0.103). Length of hospital stay was 30 versus 17 days in the VAMMFT and BB groups, respectively (OR 1.41 [1.30–1.54]). There were no independent predictors of closure identified in the VAMMFT group. Older patients were less likely to achieve closure when BB was used (OR 0.97 [0.95–0.99]). VAMMFT failure was commonly due to lack of stock (39%) and protocol violations (33%).ConclusionThe VAMMFT approach to the OA is efficacious and safe. VAMMFT achieves a much higher rate of secondary closure than BB alone with a low rate of enteric fistula formation.
Predictors of physical frailty improvement in older patients enrolled in a multidisciplinary cardiac rehabilitation program
Authors: Baldasseroni Samuele , Silverii Maria Vittoria , Herbst Andrea , Orso Francesco , Di Bari Mauro , Pratesi Alessandra , Burgisser Costanza , Ungar Andrea , Marchionni Niccolò , Fattirolli Francesco 
Published: March 2023

AbstractCardiac rehabilitation (CR) improves clinical and functional recovery in older patients after acute cardiac syndromes, whose outcome is influenced by cardiac disease severity, but also by comorbidity and frailty. The aim of the study was to analyze the predictors of physical frailty improvement during the CR program. Data were collected in all patients aged > 75 years consecutively admitted from 1 January to December 2017 to our CR, consisting of 5-day-per-week of 30-min session of biking or calisthenics on alternate days for 4 weeks. Physical frailty was measured with short physical performance battery (SPPB) at the entry and the end of CR. Outcome was represented by an increase of at least 1 point in the SPPB score from baseline to the end of the CR program. In our study population of 100 patients, mean age 81 years, we demonstrated that a strong predictor of improvement in SPPB score was the poorer performance in the test at baseline; for Δ-1 point of score, we registered an OR 2.50 (95% CI = 1.64–3.85; p = 0.001) of probability to improve the physical performance at the end of CR. Interestingly those patients with worse performance at SPPB balance and chair standing task showed greater probability of ameliorating their physical frailty profile at the end of CR. Our data strongly suggest that CR program after acute cardiac syndrome produces a significant physical frailty improvement in those patients with worse frailty phenotype with an impairment in chair standing or balance at entry.
Non-surgical management in children with non-refluxing primary megaureter: a systematic review and meta-analysis
Authors: Buder Kathrin , Opherk Kathrin , Mazzi Sara , Rohner Katharina , Weitz Marcus 
Published: March 2023

Abstract
Background
Children with non-refluxing primary megaureter are mostly managed by a watchful approach with close follow-up and serial imaging.

Objectives
This systematic review and meta-analysis aimed to determine whether there is sufficient evidence to support the current non-surgical management strategy in these patients.

Data sources
A comprehensive search including electronic literature databases, clinical trial registries, and conference proceedings was performed.

Data synthesis methods
Outcomes were estimated as pooled prevalence. If meta-analytical calculations were not appropriate, outcomes were provided in a descriptive manner.

Results
Data from 8 studies (290 patients/354 renal units) were included. For the primary outcome, differential renal function estimated by functional imaging, meta-analysis was impossible due to reported data not being precise. Pooled prevalence for secondary surgery was 13% (95% confidence interval: 8–19%) and for resolution 61% (95% confidence interval: 42–78%). The risk of bias was moderate or high in most studies.

Limitations
This analysis was limited by the low number of eligible studies with few participants and high clinical heterogeneity, and the poor quality of the available data.

Conclusions
The low pooled prevalence of secondary surgical intervention and high pooled prevalence of resolution may support the current non-surgical management in children with non-refluxing primary megaureter. However, these results should be interpreted cautiously due to the limited available body of evidence. Future studies should overcome existing limitations of imaging methods by using standardized, comparable criteria and report outcome parameters in a quantitative manner. This would allow more sufficient data synthesis to provide evidence-based recommendations for clinical decision-making and counseling.

Systematic review registration
The protocol was registered on PROSPERO under CRD42019134502.
What motivates and hinders municipal adaptation policy? Exploring vertical and horizontal diffusion in Hessen and Finland
Authors: Schoenefeld Jonas J. , Hildén Mikael , Schulze Kai , Sorvali Jaana 
Published: March 2023

AbstractMunicipalities across the globe are seeking to adapt to increasing climate change impacts, such as heavy rainfall, drought, heat waves, and floods. An important question is how to support the diffusion of innovations in local adaptation policy-making. Responses often lack consideration of the diversity of municipalities and their varying needs and capacities. This article addresses this gap by analysing how internal and external motivations for and barriers to adaptation policy and diffusion vary across municipalities of different sizes in the federal State of Hessen in Germany and in Finland. Hessen and Finland have comparable population sizes and settlement structures, but their municipalities are embedded in different multilevel governance architectures and climatic geographies. The analysis builds on quantitative data from two independent surveys among Hessian and Finnish municipalities. The results show that while there are similarities and some differences among the motivations, with municipalities in Hessen focusing more on extreme weather events and Finnish municipalities more on well-being, the barriers are strikingly similar, focusing on lack of resources as well as unclear responsibilities of different governance levels and within municipalities. Size is an important factor determining the adaptation needs and capacities of municipalities in both surveys. The findings highlight the need for a clearer adaptation governance framework, support from the closest governance level and more resources, but also context-sensitive policy support that has been discussed in theory and practice.
A spatial semiparametric M-quantile regression for hedonic price modelling
Authors: Schirripa Spagnolo Francesco , Borgoni Riccardo , Carcagnì Antonella , Michelangeli Alessandra , Salvati Nicola 
Published: March 2023

AbstractThis paper proposes an M-quantile regression approach to address the heterogeneity of the housing market in a modern European city. We show how M-quantile modelling is a rich and flexible tool for empirical market price data analysis, allowing us to obtain a robust estimation of the hedonic price function whilst accounting for different sources of heterogeneity in market prices. The suggested methodology can generally be used to analyse nonlinear interactions between prices and predictors. In particular, we develop a spatial semiparametric M-quantile model to capture both the potential nonlinear effects of the cultural environment on pricing and spatial trends. In both cases, nonlinearity is introduced into the model using appropriate bases functions. We show how the implicit price associated with the variable that measures cultural amenities can be determined in this semiparametric framework. Our findings show that the effect of several housing attributes and urban amenities differs significantly across the response distribution, suggesting that buyers of lower-priced properties behave differently than buyers of higher-priced properties.
Can acid produced from probiotic bacteria alter the surface roughness, microhardness, and elemental composition of enamel? An in vitro study
Authors: Saha Swagata , Chopra Aditi , Kamath Shobha Ullas , Kashyap Namita N. 
Published: March 2023

AbstractProbiotics are live microorganisms that upon administration in adequate amounts provide various health benefits to the host. Probiotics are “lactic acid-producing bacteria” as they release large amounts of organic acids, particularly lactic acids, in their surrounding environment. Although the acids produced by probiotics are beneficial for gastrointestinal and vaginal health, the acidogenic nature of probiotics has raised concerns among dental professionals, especially concerning their effect on the enamel and dentin. Previous studies have found that probiotics can lower the pH of the saliva and cause essential elements like Calcium and Phosphorus to leach from the enamel. This can alter the surface topography of enamel and increase the risk of enamel defects. Studies have also noted that probiotic bacteria can replace cariogenic bacteria and lower the risk of tooth decay. However, the effect of acid produced by probiotics on the enamel surface remains unclear. Hence, the present study aims to evaluate the effect of probiotics on the surface roughness, microhardness, and elemental composition of enamel compared to 0.1 M Lactic acid (demineralizing agent). Twenty enamel sections were randomly divided into groups and subjected to a pH cycling model using a probiotic suspension and 0.1 M lactic acid. The changes in the surface roughness, microhardness, surface morphology, and elemental composition of the enamel with regard to Carbon, Oxygen, Sodium, Hydrogen, Magnesium, Phosphorus, Fluoride, Chlorine, and Calcium of the enamel were evaluated before and after the emersion in both the groups. The results showed a significant increase in the mean surface roughness in the probiotic group before and after the exposure. The microhardness of the enamel decreased along with altered arrangement of the enamel prisms, increased striations, scratch marks, and pitting after exposure to the probiotic group. A decrease in the atomic/weight% for Calcium, Phosphorous, Fluoride, Aluminium, and Oxygen and an increase in the weight/atomic% for Carbon, Nitrogen, and Sodium were noted compared to the baseline in the probiotic solution. The results in the probiotic group were comparable to the 0.1 M lactic acids. The pH changed from 5.78 to 3.06 at the end of 24 h in the probiotic group. Based on these findings, we conclude that exposure to probiotics can affect microhardness and surface roughness and cause leaching of essential elements like Calcium and Phosphorous from the enamel.
Subclinical systolic dysfunction detected by 2D speckle tracking echocardiography in adults with diabetes mellitus: systematic review and meta-analysis of 6668 individuals with diabetes mellitus and 7218 controls
Authors: Ghoreyshi-Hefzabad Seyed-Mohammad , Jeyaprakash Prajith , Vo Ha Q. , Gupta Alpa , Ozawa Koya , Pathan Faraz , Negishi Kazuaki 
Published: March 2023

Abstract
Purpose
Speckle tracking echocardiography (STE) can help to identify subclinical features of diabetic cardiomyopathy (DCM). There is, however, significant heterogeneity in the reported strain values in literature. We performed a systematic review and meta-analysis to compare cardiac systolic strain values assessed by 2D-STE in asymptomatic adults with diabetes mellitus (DM) and healthy controls.

Methods
Five databases were searched, and a total of 41 valid studies (6668 individuals with DM and 7218 controls) were included for analysis. Pooled mean in each group and mean difference (MD) for left ventricular global longitudinal strain (LVGLS), LV global circumferential strain (LVGCS), LV global radial strain (LVGRS), LV longitudinal systolic strain rate (LVSR), left atrial reservoir strain (LARS) and right ventricular GLS (RVGLS) were assessed.

Results
Patients with DM had overall 2 units lower LVGLS than healthy subjects 17.5% [16.8, 18.3], vs 19.5 [18.7, 20.4], MD = − 1.96 [− 2.27, − 1.64]. Other strain values were also lower in patients with DM: LVGCS (MD = − 0.89 [− 1.26, − 0.51]); LVGRS (MD = − 5.03 [− 7.18, − 2.87]); LVSR (MD = − 0.06 [− 0.10, − 0.03]); LARS (MD = − 8.41 [− 11.5, − 5.33]); and RVGLS (MD = − 2.41 [− 3.60, − 1.22]). Meta-regression identified higher body mass index (BMI) as the single contributor to worse LVGLS, LVGCS and LVSR. Those with higher Hemoglobulin A1c had worse RVGLS.

Conclusion
Myocardial strains were reduced in whole heart in patients with DM. The largest reduction was observed in LA reservoir strain, followed by RVGLS and LVGLS. Higher BMI in patients with DM is associated with worse LV strain values.
Indigenous LGBTIQSB + People’s Experiences of Family Violence in Australia
Authors: Soldatic Karen , Sullivan Corrinne T. , Briskman Linda , Leha John , Trewlynn William , Spurway Kim 
Published: March 2023

Abstract
Purpose
This article uses an Indigenous concept of family violence as a frame to interrogate interviews held with Indigenous LGBTIQSB + people in Australia. The article reorients family violence away from Western heteronormative framings and aims to contribute towards a new conversation about family violence.

Methods
A qualitative thematic analysis was used to analyse 16 interviews with Indigenous LGBTIQSB + people in the state of New South Wales, Australia. This is one of a series of articles that provide preliminary findings from a research project into the social and emotional wellbeing of Indigenous LGBTIQSB + young people living in New South Wales.

Results
The interviews highlight the complex impact family violence on Indigenous LGBTIQSB + youth. The article shows differences in reactions between family and community in urban settings with those experienced in rural settings highlighting intergenerational differences, with older family members such as grandparents, more likely to exhibit negative reactions and behaviours. These experiences are interconnected as many young people were living in urban areas while extended family often lived in rural or remote communities.

Conclusions
The findings of this study demonstrate the intersectional nature of family violence highlighting the fact that Indigenous LGBTIQSB + young people are integral parts of extended kinship networks, families and communities and are deeply impacted by any acts of family violence. The study’s findings also support current research into family and community violence for LGBTIQ + people that shows the differential behaviours and actions of rural and urban families as well as the different reactions between generations within families.
Estimating the energy consumption of model-view-controller applications
Authors: Guamán Daniel , Pérez Jennifer , Valdiviezo-Diaz Priscila 
Published: March 2023

AbstractFor information and communication technology to reach its goal of zero emissions in 2050, power consumption must be reduced, including the energy consumed by software. To develop sustainability-aware software, green metrics have been implemented to estimate the energy consumed by the execution of an application. However, they have a rebound energy consumption effect because they require an application to be executed to estimate the energy consumed after each change. To address this problem, it is necessary to construct energy estimation models that do not require the execution of applications. This work addresses this problem by constructing a green model based on size, complexity and duplicated lines to estimate the energy consumed by model-view-controller applications without their execution. This article defines a model constructed based on 52 applications. The results were accurate in twelve applications, which showed that the joule estimation was very close to reality, avoiding the energy consumed by the execution of applications.
Multiple Scratching: An Atomistic Study
Authors: Alabd Alhafez Iyad , Kopnarski Michael , Urbassek Herbert M. 
Published: March 2023

AbstractUsing molecular dynamics simulation, we investigate multiple scratching processes in which a tip moves through a groove that has already been formed during a previous scratch. We use a conical indenter such that the friction coefficient is independent of the scratch depth. First, a single scratch to a depth of 4 nm is compared with a 2-cycle scratch in which a scratch at depth 2 nm is followed by a second scratch to the full depth of 4 nm. We observe that the second cycle shows a smaller friction coefficient as long as the tip moves through the pre-formed groove without touching the front end. In addition, we studied 5 cycles of scratching, in which the scratch depth was increased by 2 nm in each cycle. These results confirm and generalize the findings for the 2-cycle scratch. A constant-load 2-cycle scratch simulation emphasizes that the reduction in transverse load—and, consequently, in the friction coefficient—is caused by the fact that, despite a large normal area supporting the normal load, only a thin area is available to resist the transverse movement of the scratch tip. The work done during scratching is in good approximation proportional to the scratch volume showing that the transverse hardness is approximately constant in all scratch processes investigated here.