bluuebunny/crossref_metadata_2025_split huggingface dataset:
Novel Antifungal and Antifeedant Metabolites from Penicillium chrysogenum Co‐Cultured with Nemania primolutea and Aspergillus fumigatus
Authors: Cen Rong‐Huan , Li Shi‐Yu , Yang Ya‐Bin , Yang Xue‐Qiong , Ding Zhong‐Tao 
Published: March 2023

AbstractThe endophyte Nemania primolutea, inhibited the growth of Penicillium chrysogenum in the coculture system. Four new compounds, nemmolutines A–B (1–2), and penigenumin (3) from N. primolutea, penemin (4) from P. chrysogenum were isolated from the coculture. On the other hand, P. chrysogenum inhibited the Aspergillus fumigatus in the coculture. Induced metabolites (13–16) with monasone naphthoquinone scaffolds including a new one from P. chrysogenum were produced by the coculture of P. chrysogenum, and A. fumigatus. Interesting, cryptic metabolites penicichrins A–B isolated from wild P. chrysogenum induced by host Ziziphus jujuba medium were also found in induced P. chrysogenum cultured in PDB ordinary medium. So the induction of penicichrin production by supplementing with host extract occurred in the fungus P. chrysogenum not the host medium. The productions of penicichrins were the spontaneous metabolism, and the metabolites (13–16) were the culture driven. Compounds 4, 6, 8, 10, 11, 14, and 15 showed significant antifungal activities against the phytopathogen Alternaria alternata with MICS of 1–8 μg/mL, and compounds 7, 9, and 12 indicated significant antifeedant activities against silkworms with feeding deterrence indexes (FDIs) of 92 %, 66 %, and 64 %. The carboxy group in 4‐(2‐hydroxybutynoxy)benzoic acid derivatives, and xylabisboeins; the hydroxy group in mellein derivatives; and the quinoid in monasone naphthoquinone increased the antifungal activities.
Better together? Maybe not with CTO‐PCI
Authors: Seto Arnold H. , Tehrani David M. 
Published: March 2023

Key points
Double‐scrubbing or multioperator chronic total occlusion (CTO) percutaneous coronary intervention (PCI) has been postulated to enhance procedural success and efficiency in complex procedures.
The present study shows no difference in success rates with single‐ or multioperator CTO‐PCI, and less efficiency in terms of time, contrast, and radiation despite single‐operators having more complex cases.
Multioperator CTO‐PCI provides ongoing training and experience in complex procedures rather than any benefits in procedural success or efficiency, and should be utilized mainly when additional training is required.
A tale of two registries: Trends and outcomes of percutaneous coronary intervention in two transatlantic populations
Authors: Lee Aaron , Gilchrist Ian C. 
Published: March 2023

Key Points
Patients undergoing percutaneous coronary intervention (PCI) in the state of Michigan have more comorbidities compared to patients undergoing PCI in the United Kingdom.
While the adoption of radial artery access for PCI has increased steadily over time in both Michigan and the United Kingdom, the use of radial access was significantly greater in the UK at all time points compared to Michigan for all PCI indications.
The use of mechanical support during PCI has increased over time in Michigan but decreased over time in the United Kingdom.
Cantú syndrome: A new case and evolution of clinical conditions during first 2‐year follow‐up
Authors: Mattiucci Alessandra , Girolomoni Giampiero , Cassina Matteo , Zoller Thomas , Antoniazzi Franco , Schena Donatella 
Published: March 2023

AbstractCantú syndrome, or hypertrichotic osteochondrodysplasia, is a rare autosomal dominant disease characterized by congenital hypertrichosis, characteristic dysmorphisms, skeletal abnormalities and cardiomegaly. We report on a 7‐year‐old girl with congenital generalized hypertrichosis, coarse facial appearance and cardiac involvement, with a de novo heterozygous mutation (c.3461G > A) in the ABCC9 gene. During the annual cardiac follow‐up at the age of nine the echocardiogram showed mild left ventricular dilatation in consideration of which she started ramipril treatment. The progression of the clinical manifestations of Cantú syndrome highlights the relevance of an early diagnosis, including genetic analysis, and a multidisciplinary approach with long‐term follow‐up.
Intraventricular gradients—When we have to “exercise” our minds: A case report
Authors: Cotrim Nuno , Cunha Pedro Silva , Guardado Jorge , Cotrim Carlos , Baquero Luís 
Published: March 2023

AbstractIncreased intraventricular pressure gradients due to dynamic left ventricular outflow tract obstruction during exercise have long been known to cause different symptoms. Exercise stress echocardiography is fundamental in the diagnostic approach of symptoms presenting during exercise. We hypothesize on the possible pathophysiological mechanisms responsible for our patient's syncopal episodes.
Fibrolipomatous hamartoma of the median nerve: An unusual cause of carpal tunnel syndrome
Authors: Siqueira Mario Gilberto , Martins Roberto Sérgio , Foroni Luciano , de Oliveira Adilson J. M. , Lordelo Gustavo , Heise Carlos Otto 
Published: March 2023

AbstractFibrolipomatous hamartoma is a rare benign tumor‐like condition that affects most commonly the median nerve. The diagnosis is usually confirmed through its typical appearance on magnetic resonance imaging (MRI) without the need for a nerve biopsy. There are divergent views regarding treatment of this entity, but open carpal tunnel release for nerve decompression currently constitutes the standard care for alleviation of compressive neuropathy of the median nerve. In this report, we describe a case of fibrolipomatous hamartoma that was diagnosed via MRI and underwent open carpal tunnel release, with alleviation of the patient's symptoms.
Redox‐Stabilized Sn/SnO2 Nanostructures for Efficient and Stable CO2 Electroreduction to Formate
Authors: Jiang Haoyang , Fan Ziqi , Zhang Mingzhe , Guo Shuyi , Li Le , Yu Xiaohan , Liu Zhaoyang , Wang Wei , Dong Hao , Zhong Miao 
Published: March 2023

AbstractElectroreduction of CO2 (CO2R) to formate enables the storage of renewable electricity in liquid chemical bonds in an efficient manner. However, hydrogen evolution competes with CO2R, decreasing Faradaic efficiency (FE) and energy efficiency (EE) for formate production, particularly under acidic and neutral conditions. The deterioration of the catalysts during CO2R further hinders long‐term and effective operation. To overcome these challenges, we fabricate nanostructured Sn/SnO2 through physical evaporation and wet‐chemical etching, improving the CO2‐to‐formate conversion with finely tuned *OCHO adsorption. The in‐situ formation of Sn/SnO2 surfaces during CO2R stabilizes the active sites for reliable formate production across a broad range of electrolyte pH from base to neutral. Our results show a 94 % CO2R‐to‐formate FE and a 58 % formate cathodic EE at 100 mA cm−2 in 1 M KOH over 70 hours of continuous operation. Under neutral conditions (pH=7), the CO2‐to‐formate conversion remains stable for 100 h with a selectivity of >90 %.
Inclusion Complex Formation with Tetra‐PEGylated Tetraphenylporphyrin and Face‐to‐Face Cyclodextrin Dimer through Unprecedented Molecular Threading
Authors: Mao Qiyue , Kitagishi Hiroaki 
Published: March 2023

AbstractHerein, a host–guest inclusion complex formation between tetra‐PEGylated tetraphenylporphyrin with a per‐O‐methylated cyclodextrin (CD) dimer through the molecular threading process that is physically unexpected to occur is described. Although the molecular size of the PEGylated porphyrin is much greater than that of the CD dimer, the sandwich‐type porphyrin/CD dimer 1 : 1 inclusion complex was spontaneously formed in water. The ferrous porphyrin complex binds O2 reversibly in aqueous solution, which functions as an artificial O2 carrier in vivo. Pharmacokinetic study using rats revealed that the inclusion complex showed a long circulation in blood in contrast to the complex without PEG. We further demonstrate the unique host–guest exchange reaction from the PEGylated porphyrin/CD monomer 1/2 inclusion complex to the 1/1 complex with the CD dimer through the complete dissociation process of the CD monomers.
Stoichiometry‐Directed Two‐Level Hierarchical Growth of Lanthanide‐Based Supramolecular Nanoarchitectures
Authors: Moreno Daniel , Santos José , Parreiras Sofia O. , Martín‐Fuentes Cristina , Lauwaet Koen , Urgel José I. , Miranda Rodolfo , Martín Nazario , Gallego José M. , Écija David 
Published: March 2023

AbstractThe design of a well‐ordered arrangement of atoms on a solid surface has long been sought due to the envisioned applications in many different fields. On‐surface synthesis of metal‐organic networks is one of the most promising fabrication techniques. Hierarchical growth, which involves coordinative schemes with weaker interactions, favours the formation of extended areas with the desired complex structure. However, the control of such hierarchical growth is in its infancy, particularly for lanthanide‐based architectures. Here the hierarchical growth of a Dy‐based supramolecular nanoarchitecture on Au(111) is described. Such an assembly is based on a first hierarchical level of metallo‐supramolecular motifs, which in a second level of hierarchy self‐assemble through directional hydrogen bonds, giving rise to a periodic two‐dimensional supramolecular porous network. Notably, the size of the metal‐organic based tecton of the first level of hierarchy can be tailored by modifying the metal‐ligand stoichiometric ratio.
Synthesis, Stepwise Bromination, and Functionalization of Picene Diimide
Authors: Wang Xin , Chen Li , Li Nuoya , Wu Di , Xia Jianlong 
Published: March 2023

AbstractMaterials Synthesis and Processing Polycyclic aromatic hydrocarbon (PAH) diimides are indispensable candidates for n‐type organic semiconductors in organic optoelectronic devices. Developing new PAH diimide building blocks are of remarkable significance for material diversity and further advance in organic semiconductors. In this contribution, 4,5,8,9‐picene diimide (PiDI) was designed and synthesized. Controllable stepwise bromination of PiDI were accomplished to afford 13‐monobromo‐, 13,14‐dibromo‐, 2,13,14‐tribromo‐ and 2,11,13,14‐tetrabromo‐PiDI. Moreover, cyanation of 2,11,13,14‐tetrabromo‐PiDI gave the corresponding tetracyanated PiDI, which can be utilized as n‐type semiconductor with OFET electron mobility up 0.073 cm2 V−1 s−1. This result demonstrates the potential of PiDI as a building block for constructing new high‐performance electronic‐transporting materials.
Instantly evaluating bacterial infections on skin ulcers in an Asian population using a fluorescence‐emitting device
Authors: Kurokami Yu , Kurosaki Yukiho , Yamashita Chigusa , Yokoi Kazunori , Tonomura Kyoko , Kiyohara Eiji , Ishitsuka Yosuke , Fujimoto Manabu , Tanemura Atsushi 
Published: March 2023

AbstractMolecuLight i:X® is a handy instrument capable of visualizing the bacterial adhesion over 10,000 CFU/g by recognizing porphyrin and pyoverdine as fluorescence. We took a total of 55 clinical photographs and fluorescence images (20 cases) from May 2021 to December 2021, after which the correlation between fluorescence observation and culture results was investigated. In addition, the course of fluorescent and ulcer status was shown in representative cases. The results suppose that MolecuLight i:X® is in real‐time use and would be helpful in determining the range of collection of bacterial cultures as well as in judging therapeutic necessity for intractable skin ulcers.
Mehr Kapazität im Schüttgutlager der Duisburger Hafenniederlassung
Authors: Mauermann Olivia 
Published: March 2023

AbstractDas Familienunternehmen Karl Schmidt ist Dienstleister für Schüttgutlogistik. Zusammen mit SSB Wägetechnik haben die Anlagenbauer im Duisburger Hafen ein Logistikzentrum für Schüttgüter aus der Chemieindustrie errichtet. Die Erweiterung der Anlage, die im Januar 2023 abgeschlossen wurde, umfasst 40 Silos. Die Schüttgutanlage arbeitet automatisiert von der Verladung bis zur Absackung und Kennzeichnung.
Mehr Effizienz beim Lithium‐Recycling
Authors: Gorman Elisabeth 
Published: March 2023

AbstractObwohl Lithium bereits für Millionen von Antriebsbatterien in Elektromobilen unverzichtbar ist, enden die Batterien und Ihre Rohstoffe wie das wertvolle Lithium nach Gebrauch noch zu 95 % im Müll, weil die konventionellen Recyclingverfahren zu teuer sind. Forscher bei Evonik setzen auf einen Elektrolyse‐Prozess mit einer Keramikmembran, bei dem auch Wasserstoff entsteht.
Kompakte Fluidiksysteme regeln Betriebsmedien
Authors: Renninger Jürgen 
Published: March 2023

AbstractPharmazeutische Anlagen für das Mahlen und die Pulver‐ bzw. Partikelaufbereitung benötigen eine individuell gestaltete Prozessgas‐ und Flüssigkeitsverteilung. Bürkert Fluid Control Systems bietet dafür verschweißte Ventilplattformen, die die Medienführung wirtschaftlicher gestalten.
Modular und Ex‐geschützt
Authors: Friedrich Horst 
Published: March 2023

AbstractDie neuen komplett modular aufgebauten HMI‐Bedienstationen ORCA wurden speziell für diese Anforderungen in explosionsgefährdeten Bereichen entwickelt und sind auch für den Einsatz in der Produktion unter hygienischen Bedingen wie in der Pharmaindustrie geeignet.
Neue Automatisierungstechnik in Brownfield‐Anlagen
Authors: Schollähn Burkhard 
Published: March 2023

AbstractAnlagen laufen meist über viele Jahrzehnte, wobei sich die in ihnen gefertigten Produkte oder der Stand der Technik in deutlich kürzeren Abständen ändern. Da eine Neuanschaffung häufig zu teuer ist, müssen die Bownfield‐Anlagen daher an die neuen Rahmenbedingungen adaptiert werden. Eine anlagenspezifische Systemverkabelung unterstützt beim zuverlässigen und schnellen Umstieg auf eine moderne Steuerungstechnik..
CO2 capture by benzene‐based hypercrosslinked polymer adsorbent: Artificial neural network and response surface methodology
Authors: Moradi Mohammad Reza , Ramezanipour Penchah Hamid , Ghaemi Ahad 
Published: March 2023

AbstractIn this research, porous benzene‐based hypercrosslinked polymeric adsorbents with different morphological properties were synthesized through Friedel–Crafts alkylation reaction. The resulting samples were applied for CO2 capture at different operational conditions. Two modelling approaches, including artificial neural network (radial basis function [RBF] and multi layer perceptron [MLP]) and response surface methodology (RSM), were employed to investigate the effect of independent parameters on adsorption capacity. A semi‐empirical quadratic model for adsorption capacity was presented based on RSM‐central composite design technique. Additionally, the optimal structure of RBF was determined with 200 neurons, and the optimal structure of MLP was determined with three hidden layers and 10, 8, and 7 neurons. The modelling results demonstrate the better prediction of MLP and RBF approaches than the RSM method with correlation coefficient values of 0.999, 0.989, and 0.931, respectively. Finally, process optimization was carried out using RSM optimization module and the optimized values of synthesis time, crosslinker ratio (formaldehyde dimethyl acetal [FDA]/benzene), adsorption time, pressure, and temperature were obtained at 10.11 h, 1, 220 s, 9 bar, and 55°C, respectively. The optimum value of CO2 uptake capacity was obtained around 167 (mg/g).
Advances and challenges in designing MXene quantum dots for sensors
Authors: Cheng Yonghua , Jiang Bowen , Chaemchuen Somboon , Verpoort Francis , Kou Zongkui 
Published: March 2023

AbstractMXene quantum dots (MQDs) sensor is a promising platform for identifying target analytes by sensing fluorescence, electrochemical signals, photoluminescence, biomedical, and so on. On the way to designing MQDs in the sensors, substantial progress has been made with basic scientific and technological hurdles remaining. Combining specific functional designs of MQDs with mechanistic understanding provides new research prospects and technology opportunities even at the industrial level. However, MQDs must be able to detect target analytes with higher sensitivity, robust stability, and applied compatibility. Here, we review the recent advances and challenges in the synthetic strategies and rational design of MQDs. By zooming in on several representative examples, we discuss the existing potentials of MQDs in the application of fluorescence, electrochemical luminescence, photoluminescence, colorimetric/fluorescent dual‐mode, and biomedical sensors. Finally, we identify the opportunities and challenges to further understanding of MQDs sensors.
Large Thermally Irreversible Photoinduced Shift of Selective Light Reflection in Hydrazone‐Containing Cholesteric Polymer Systems
Authors: Boychuk Artem , Shibaev Valery , Cigl Martin , Hamplová Vĕra , Novotná Vladimíra , Bobrovsky Alexey 
Published: March 2023

AbstractStimuli responsive liquid crystalline polymers are a unique class of so‐called “smart” materials demonstrating various types of mesomorphic structures easily controlled by external fields, including light. In the present work we synthesized and studied a comb‐shaped hydrazone‐containing copolyacrylate exhibited cholesteric liquid crystalline properties with the pitch length of the helix being tuned under irradiation with light. In the cholesteric phase selective light reflection in the near IR spectral range (1650 nm) was measured and a large blue shift of the reflection peak from 1650 nm to 500 nm was found under blue light (428 or 457 nm) irradiation. This shift is related to the Z‐E isomerization of photochromic hydrazone‐containing groups and it is photochemically reversible. The improved and faster photo‐optical response was found after copolymer doping with 10 wt % of low‐molar‐mass liquid crystal. It is noteworthy that both, the E and Z isomers of hydrazone photochromic group are thermally stable that enable to achieve a pure photoinduced switch without any dark relaxation at any temperatures. The large photoinduced shift of the selective light reflection, together with thermal bistability, makes such systems promising for applications in photonics.
Exploring Glycosylated Soy Isoflavones Affinities toward G‐tetrads as Studied by Survival Yield Method
Authors: Stężycka Olga , Frańska Magdalena , Beszterda‐Buszczak Monika 
Published: March 2023

AbstractTaking soy‐based food supplements for menopausal symptoms by women may reduce the risk of cancer. Therefore, the interaction between nucleic acids (or their constituents) and ingredients of the supplements, e. g., isoflavone glucosides, on the molecular level, has been of interest with respect to cancer therapy. In this work, the interaction between isoflavone glucosides and G‐tetrads, namely [4G+Na]+ ions (G stands for guanosine or deoxyguanosine), were analyzed by using electrospray ionization‐collision induced dissociation‐mass spectrometry (ESI‐CID‐MS) and survival yields method. The strength of isoflavone glucosides‐[4G+Na]+ interaction in the gas phase was determined from Ecom50 – the energy required to fragment 50 % of selected precursor ions. Glycitin‐[4G+Na]+ interaction was found to be the strongest, and the interaction between isoflavone glucosides and guanosine tetrad was established to be stronger than that between isoflavone glucosides and deoxyguanosine tetrad.
Study on the Intrinsic Correlation between Sintering Method, Ion Diffusion, and Dielectric Properties of Ba0.5Sr0.5TiO3‐ZnAl2O4 Composite Ceramics
Authors: Zhang Xianxin , Xin Le , Zhang Mingwei , Zhai Jiwei 
Published: March 2023

AbstractBa0.5Sr0.5TiO3‐ZnAl2O4 composite ceramics of different components are prepared by solid‐phase sintering and microwave sintering, respectively. The ion diffusion phenomenon between the two phases under different sintering methods and the effect of sintering method on the microstructure and dielectric properties of composite ceramics are studied. The results show that during solid‐phase sintering, the generation of liquid phase can effectively enhance the ion diffusion between the two phases. Compared with solid‐phase sintering, microwave sintering effectively reduces the sintering temperature of composite ceramics, and the refinement of grains enhances the ion diffusion between the two phases, resulting in an increase in the Ba/Sr ratio, and the Curie temperature moves to high temperature and increases the tunability. Under microwave sintering conditions, when the ZnAl2O4 content is 50 wt%, the tunability of the composite ceramics reaches 40.03%, and it has a good Q‐value.
Vulnerability of protected areas to future climate change, land use modification, and biological invasions in China
Authors: Xin Yusi , Yang Zhixu , Du Yuanbao , Cui Ruina , Xi Yonghong , Liu Xuan 
Published: March 2023

AbstractAnthropogenic climate change, land use modifications, and alien species invasions are major threats to global biodiversity. Protected areas (PAs) are regarded as the cornerstone of biodiversity conservation, however, few studies have quantified the vulnerability of PAs to these global change factors together. Here, we overlay the risks of climate change, land use change, and alien vertebrate establishment within boundaries of a total of 1020 PAs with different administrative levels in China to quantify their vulnerabilities. Our results show that 56.6% of PAs will face at least one stress factor, and 21 PAs are threatened under the highest risk with three stressors simultaneously. PAs designed for forest conservation in Southwest and South China are most sensitive to the three global change factors. In addition, wildlife and wetland PAs are predicted to mainly experience climate change and high land use anthropogenetic modifications, and many wildlife PAs can also provide suitable habitats for alien vertebrate establishment. Our study highlights the urgent need for proactive conservation and management planning of Chinese PAs by considering different global change factors together.
Revisiting the nutraceutical profile, chemical composition, and health benefits of jaggery: Updates from recent decade
Authors: Sharifi‐Rad Javad , Painuli Sakshi , Sener Bilge , Kılıç Mehtap , Kumar Nanjangud V. A. , Semwal Prabhakar , Docea Anca O. , Suleria Hafiz A. R. , Calina Daniela 
Published: March 2023

AbstractFoods as medicine have been utilized from ancient civilizations and shared from generation to generation as dietary health practices. It provides therapeutic assistance along with nutrition and health benefits. Presently, food products, diet, and individual health are receiving a lot of attention and are in high demand. In this context, jaggery is an important part of food and diet in the rural areas of many regions/countries. It is made up of sugarcane juice and is recognized as a natural source of nutraceuticals due to the presence of different types of essential amino acids, minerals, vitamins, and antioxidant potential along with other biological applications. In this updated review article, we discussed the newest research and information on traditional uses, nutraceutical profiling, chemical composition, and biological applications of jaggery. The published data were collected from different scientific search engines including PubMed, Springer Link, Web of Science, Google Scholar, Science Direct, and Wiley online library. Given these findings, we can conclude that jaggery is a strong source of nutraceuticals and its nutraceutical potential can be enhanced with value addition and other scientific interventions. Detailed investigations on preclinical (in silico, in vitro, and in vivo) studies along with its actual mechanism of action in depth are required. Additionally, clinical trials also should be conducted to validate the preclinical studies.