bluuebunny/crossref_metadata_2025_split huggingface dataset:
Incidence and risk factors of acute bilirubin encephalopathy in neonates with hyperbilirubinemia presenting at secondary care hospital
Authors: Rauf Saba , Salah ud Din Bushra , Abbas Ghanwa , Nawaz Zeeshan 
Published: February 2023

Background & Objectives: In neonates, hyperbilirubinemia is the most common problem. Acute bilirubin encephalopathy is serious problem in less developed nations and their incidence varies with geographical location. Our objective was to find out the incidence and risk factors of acute bilirubin encephalopathy in neonates with hyperbilirubinemia
Methods: This was a prospective cross sectional study carried out at the department of pediatrics, THQ Hospital, Pindigheb in Punjab from October 2020 to October 2021. The inclusion criterion for our study was all the neonates of both the gender diagnosed with hyperbilirubinemia. Blood samples were collected from all the neonates and were sent to hospital laboratory for total serum bilirubin (TSB) measurement. The risk factors like delivery place, Rh/ABO incompatibility and preterm delivery were recorded. SPSS version 23 was used to input and analyze all of the data.
Results: In this study, a total of 350 neonates were included. The prevalence of acute bilirubin encephalopathy in our study was 16% (n=56). Seven (12.5%) neonates with acute bilirubin encephalopathy were preterm which was the major significant risk factor for acute bilirubin encephalopathy in hyperbilirubinemia neonates (p<0.05). The other risk factors such as hospital delivery, birth weight, Rh and ABO incompatibility were also observed but were non-significant (p>0.05).
Conclusion: Our study observed 16% prevalence of acute bilirubin encephalopathy in neonates with hyperbilirubinemia. The preterm birth was a significant risk factor associated with the acute bilirubin encephalopathy in neonates with hyperbilirubinemia.
doi: https://doi.org/10.12669/pjms.39.2.5996
How to cite this: Rauf S, Salah-ud-Din B, Abbas G, Nawaz Z. Incidence and risk factors of acute bilirubin encephalopathy in neonates with hyperbilirubinemia presenting at secondary care hospital. Pak J Med Sci. 2023;39(2):583-586. doi: https://doi.org/10.12669/pjms.39.2.5996
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Electronic invoicing: a cross sectional study of its implementation in micro and small businesses in Lima, Peru
Authors: Grijalva Salazar Rosario Violeta , Fernández-Bedoya Víctor Hugo , Ibarra Fretell Walter Gregorio , Cuba Mayuri Ena Elizabeth , Yzaguirre Ruiz Marco Antonio 
Published: February 2023

Background: The implementation of electronic taxation systems helps every company to be able to control, verify and simplify its tax operations. It allows them to manage all their obligations in a faster and more efficient way. In this study, we aim to deduce from the accountants' perspective, what attitudes, practices and compliance with tax obligations are being carried out as a result of the implementation of electronic invoicing. Likewise, to note the benefits it has brought to Micro and Small Enterprises during COVID-19 in Peru. Methods: We used methods of applied research with a quantitative and non-experimental approach. The sample consisted of 384 accountants who manage taxation in their respective companies in Metropolitan Lima, to whom a questionnaire was applied as a data collection instrument. Results: The study sample believes that the use of an electronic issuance system can help combat tax evasion (9.6%), cumbersome tax audits (38.8%), informality (9.4%), falsification of payment vouchers (8.9%), loss and deterioration of payment vouchers (9.1%) and informality (8.3%). They also consider, in their opinion, that the use of the electronic tax system has greatly facilitated the taxation processes (96.6%), generated a reduction in costs (96.4%), reduced the use or consumption of paper (96.9%) and streamlined the administrative and accounting operations (97.4%) of the MSEs Conclusions: It is evident that the sample is in favour of the implementation with an electronic tax system in their business. This new system would be a promising means to help businesses voluntarily comply with their tax obligations. In turn, it generates a positive effect on tax collection and compliance levels.
AMAW: automated gene annotation for non-model eukaryotic genomes
Authors: Meunier Loïc , Baurain Denis , Cornet Luc 
Published: February 2023

Background: The annotation of genomes is a crucial step regarding the analysis of new genomic data and resulting insights, and this especially for emerging organisms which allow researchers to access unexplored lineages, so as to expand our knowledge of poorly represented taxonomic groups. Complete pipelines for eukaryotic genome annotation have been proposed for more than a decade, but the issue is still challenging. One of the most widely used tools in the field is MAKER2, an annotation pipeline using experimental evidence (mRNA-seq and proteins) and combining different gene prediction tools. MAKER2 enables individual laboratories and small-scale projects to annotate non-model organisms for which pre-existing gene models are not available. The optimal use of MAKER2 requires gathering evidence data (by searching and assembling transcripts, and/or collecting homologous proteins from related organisms), elaborating the best annotation strategy (training of gene models) and efficiently orchestrating the different steps of the software in a grid computing environment, which is tedious, time-consuming and requires a great deal of bioinformatic skills. Methods: To address these issues, we present AMAW (Automated MAKER2 Annotation Wrapper), a wrapper pipeline for MAKER2 that automates the above-mentioned tasks. Importantly, AMAW also exists as a Singularity container recipe easy to deploy on a grid computer, thereby overcoming the tricky installation of MAKER2. Use case: The performance of AMAW is illustrated through the annotation of a selection of 32 protist genomes, for which we compared its annotations with those produced with gene models directly available in AUGUSTUS. Conclusions: Importantly, AMAW also exists as a Singularity container recipe easy to deploy on a grid computer, thereby overcoming the tricky installation of MAKER2
Healthcare providers’ perspective on barriers to optimal HIV index testing: an interview-based study
Authors: Katamba Cibangu 
Published: February 2023

Background: HIV testing services (HTS) and antiretroviral therapy have seen a substantial scale-up. Poorly targeted HTS have continued to miss people living with HIV who do not know their HIV status. This requires new and targeted approaches to reach undiagnosed people with HIV, such as HIV partner services. The aim of this study was to assess the barriers to optimal index testing for improved HIV testing yield in Lusaka, Zambia. Methods: One-to-one interviews were conducted with index testing providers to explore provider-related and client-related barriers to testing, and document other experiences arising during the process of HIV index testing. An interview guide was utilized for consistency of information collected. Results: Provider related challenges included inadequate elicitation skills among healthcare workers; low number of volunteers trained in index testing; inadequate index testing knowledge among staff; age and sex differences; limited elicitation of index partners to only wife and husband (not eliciting all sexual partners); and limited transport for contact tracing. On the other hand, client-related challenges were mobile communities due to seasonal activities such as cross boarder trades, sex work and farming; some key populations and adolescent index clients do not have contact details for their casual relationships; provider’s age or gender difference for some clients; missing details on client locator forms or wrong details provided; stigma and discrimination; and limited space dedicated to conduct elicitation of index clients. Discussion: The challenges identified have future implications for index partner testing. These barriers were also gender and age specific. HIV testing services need to adapt to the social context of Zambia where HIV-related stigma and discrimination is still a challenge. As Zambia makes significant progress towards achieving HIV epidemic control, more effort is needed to address specific barriers to optimal HIV index testing.
Simulation framework for connected vehicles: a scoping review
Authors: Abdul Razak Siti Fatimah , Yogarayan Sumendra , Azman Afizan , Abdullah Mohd Fikri Azli , Muhamad Amin Anang Hudaya , Salleh Mazzar 
Published: February 2023

Background: V2V (Vehicle-to-Vehicle) is a booming research field with a diverse set of services and applications. Most researchers rely on vehicular simulation tools to model traffic and road conditions and evaluate the performance of network protocols. We conducted a scoping review to consider simulators that have been reported in the literature based on successful implementation of V2V systems, tutorials, documentation, examples, and/or discussion groups. Methods: Simulators that have limited information were not included. The selected simulators are described individually and compared based on their requirements and features, i.e., origin, traffic model, scalability, and traffic features. This scoping review was reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR). The review considered only research published in English (in journals and conference papers) completed after 2015. Further, three reviewers initiated the data extraction phase to retrieve information from the published papers. Results: Most simulators can simulate system behaviour by modelling the events according to pre-defined scenarios. However, the main challenge faced is integrating the three components to simulate a road environment in either microscopic, macroscopic or mesoscopic models. These components include mobility generators, VANET simulators and network simulators. These simulators require the integration and synchronisation of the transportation domain and the communication domain. Simulation modelling can be run using a different types of simulators that are cost-effective and scalable for evaluating the performance of V2V systems in urban environments. In addition, we also considered the ability of the vehicular simulation tools to support wireless sensors. Conclusions: The outcome of this study may reduce the time required for other researchers to work on other applications involving V2V systems and as a reference for the study and development of new traffic simulators.
Usage of personas in the construction industry
Authors: Sainz Salces Fausto Javier , Liinasuo Marja , Martin-Moncunill David 
Published: February 2023

Background: This study on the use of personas was carried out during a building trade related software development EU project. Participants were introduced to the personas tool and encouraged to use it in their work in technical development. Methods: A questionnaire was delivered three months after presentation and explanation of the remote tool, inquiring about benefits, drawbacks, intention of using personas in the future, and the role of usage related information as a whole in technical development. Results: Previous knowledge about the tool, perceptions of the tool and its actual use seemed to influence developers in their decision to use it or not. Conclusions: Almost half of the organizations in our study use real user-centric design methods in their technical development; this can ease the path for wider adoption of the methods when needed. One possible solution to strengthen the understanding and adoption of the user-centric methods is to spread information among technical developers, by identifying and using efficient communication channels, such as tailored training. User-centric methods seem to have gained followers in the technical development arena, indicating that this may be a feasible way for further adoption of user centricity in product development.
Chronic pruritus in atopic dermatitis – mechanisms and different ways of treatment, affect on quality of life
Authors: Ostaszewska Sandra , Morawski Przemysław , Augustynowicz Kinga , Popińska Zuzanna , Chrzanowski Jakub , Szymańska Ewa , Łoginoff Jan , Świąder Kinga , Pactwa Filip 
Published: February 2023

Introduction: Pruritus in atopic dermatitis is one of the main symptoms of the disease and the one that causes a significant impact on quality of life. It is important to control itching because it’s not only an unplesant sense. Scratching topically deepen the dermatitis, damages the epidermal barrier causing additional infections possible and makes it harder to acheive a remission of the disease. It is also highly associated with stress and has an impact on mental health of the patient. In this article we present a summary of how pruritus affects the quality of life, mechanisms of pruritus and possible treatment.
Materials and methods: Our work is based on the articles published in PubMed, medical books and websites. We were looking for the key words such as ‘stress and itch’, ‘pruritus treatment’, ‘chronic itch in atopic dermatitis’, ‘itch and quality of life’.
Results: Patients with atopic dermatitis should come under miltidisciplinar treatment to acheive the best possible control of symptoms. This will result in higher quality of life and better mental health of the patient.
Conclusions: There is a high need to develop new targeted medications as contemporary medicine knows a lot more about the mechanism of pruritus. Many new types of treatment are being studied and soon we may have more options to choose in systemic and topical therapy. We should also concetrate more on a mental side of the disease.
Pain therapy in the pediatric population
Authors: Białowąs Edyta , Mazurek Magdalena , Aghadi Artur , Cuber Iwona , Dybała Ewelina 
Published: February 2023

Introduction: The assessment and treatment of pain in the pediatric population is a huge challenge for doctors and medical staff dealing with this group of patients. It is also one of the most important elements of pediatric care practice. There are many factors that contribute to the difficulty of assessing and managing pain in children, but the most important seems to be the lack of unified standards of care. In pain therapy, both pharmacotherapy and behavioral methods and psychological care are used.
Purpose of the work: The aim of this work is to systematize the current state of knowledge in the field of pain therapy in the pediatric population, focusing particular attention on pharmacotherapy
Materials and Evidence: We reviewed the literature available in the PubMed database using the following keywords: pediatric; pain therapy; analgesia
Summary: Pain therapy in the pediatric population, despite the fact that it is often underestimated and insufficiently managed, is crucial both in terms of avoiding health complications and in the overall therapeutic process. Despite the presence of many drugs for pain therapy on the market, many of them are not approved for use in this group of patients. Knowledge of their mechanisms of action and predicting the impact on metabolism in a pediatric patient compared to an adult is crucial for the management of both acute and chronic pain syndromes. Despite the current knowledge, there is still a need for broader research on the possibility of the drugs used, their impact on the therapy process and side effects in the youngest patients.
Immunity system dysfunction caused by insomnia and methods of treatment
Authors: Augustynowicz Kinga , Szymańska Ewa , Ostaszewska Sandra , Świąder Kinga , Chrzanowski Jakub , Morawski Przemysław , Pactwa Filip , Popińska Zuzanna , Łoginoff Jan 
Published: February 2023

Introduction: Sleep is a very important part of human health. Research over the past several years has shown that sleep disorders such as insomnia can affect the risk of infectious diseases. This review describes the immunocompromising mechanisms of insomnia and the consequences associated with this disorder. This review also includes treatment methods.
Material and methods: The work was based on the articles published in PubMed, medical books and websites.
Results: Insomnia has an influence in the markers of inflammation and there are few methods of treating insomnia.
Conclusions: Sleep influences the two primary effector systems which in turn regulate immune responses. Sleep disturbance like insomnia increases the risk of infectious diseases. Treatment can lower the markers of inflammation and helps relieve the symptoms of insomnia.
Social Reference Points and Risk Taking
Authors: Schwerter Frederik 
Published: February 2023

Social reference points have been identified to be important determinants of individuals’ welfare. We investigate the consequences of social reference points for risk taking in a laboratory experiment. In the main treatments, risk-taking subjects observe the predetermined earnings of peer subjects when making a risky choice. We exogenously manipulate peers’ earnings and find a significant treatment effect: decision makers make less risk-averse choices in the case of larger peers’ earnings. The treatment effect is consistent with an application of prospect theory to social reference points and cannot be explained by reference points based on counterfactual information, anchoring, and experimenter demand effects. In additional analyses, we show that diminishing sensitivity seems to play an important role in subjects’ risky choices. We explore also whether inequity aversion and expectations-based reference points can account for our findings and conclude that they do not provide plausible alternative explanations for them. This paper was accepted by Yan Chen, behavioral economics and decision analysis. Funding: This research was financially supported by the Bonn Graduate School of Economics and the Center for Economics and Neuroscience in Bonn. Supplemental Material: The online appendix and data are available at https://doi.org/10.1287/mnsc.2023.4698 .
Genetic variability for micronutrients under an aerobic condition in local landraces of rice from different agro-ecological regions of Karnataka, India
Authors: THUY NGUYEN PHUONG , NHU TRAN THI THAO , TRAI NGUYEN NGOC , NHU NGHI KHAC , THAO NGUYEN HOANG XUAN , PHONG VUONG TUAN , KHOA BUI DANG , LUAN NGUYEN THANH 
Published: February 2023

Abstract. Thuy NP, Nhu TTT, Trai NN, Nhu NK, Thao NHX, Phong VT, Khoa BD, Luan NT. 2023. Genetic variability for micronutrients under an aerobic condition in local landraces of rice from different agroecologicalregions of Karnataka, India. Biodiversitas 24: 1-10.Genetic variability is a fundamental reference for the innovative development of breeding programs to improve varieties and desirable traits. This study aimed to assess genetic variability for micronutrients (iron and zinc) and protein content under an aerobic condition in local landraces of rice (Oryza sativa L.) from different agroecological regions of Karnataka, India. Fifty-fivelocal landraces of ricefrom India were studied.High phenotypic and genotypic coefficient of variation was observed for grain yield per plant and moderate for the remaining traits. Heritability was high for most of the traits observed while moderatefor harvest index and grain yield plant-1. The genetic advance (GA) was high for the majority of yield and its attributing traits. GA as mean was high for grain yield per plant. Based on D2value, 50 genotypes were grouped into 8 clusters. Clusters VI and VIII are the largest and had accessions with the highest protein and zinc content. Marabatta, Jeerige Batta, Neerguli, Mugadh Sughanda, and Kesarnellu genotypes contained high grain protein and zinc content, whereas Naga Batta genotype has high iron content. Among the superior nutrient landraces, Neerguli, Jeerige Batta, DBN, Kesarnellu, and Doddiga genotypes had high grain yield plant-1.
Genetic diversity and gain quantitative characters of maize from index-based selection at two dry lands in Lombok, Indonesia
Authors: SUDIKA I WAYAN , SOEMEINABOEDHY I NYOMAN , SUTRESNA I WAYAN 
Published: February 2023

Abstract. Sudika IW, Soemeinaboedhy IN, Sutresna IW. 2023. Genetic diversity and gain quantitative characters of maize from index-based selection at two dry lands in Lombok, Indonesia. Biodiversitas 24: 11-19. Genetic diversity and gain quantitative characters of maize from index-based selection at dry land is poorly reported. This research aims to study the genetic diversity and gain of several traits quantitative of the index-based selection at two dry lands in Amor-Amor and Pererenan, Lombok, Indonesia. A randomized block design with three replications was applied to design the experiment. The materials used is maize from nine populations, namely eight populations from the selection of index-based and one from the initial population. The data were analyzed for variance at the 5% significance level. The results showed that the genetic diversity of yields was categorized as moderate, and the weight of dry cobs harvested per plant was narrow in both locations. The genetic diversity of fresh stover weight per plant in Pererenan was wider than in Amor-Amor, but still in the same category, which was medium. These three traits had a significant genetic gain in the moderate category for both locations, except for the weight of fresh stover per plant, which was high in Pererenan. The dry seed weight per plant had a moderate genetic diversity and gain with a significant positive phenotypic correlation with yield. Yield and fresh stover per plant can still be increased through index-based selection by using dry seed weight per plant and fresh stover per plant in both locations.
Isolation and molecular identification of agarwood-inducing fungi and their virulence test using Aquilaria sp. seedlings
Authors: LUKMAN LUKMAN , DINARTI DINY , SIREGAR ULFAH JUNIARTI , TURJAMAN MAMAN , SUDARSONO SUDARSONO 
Published: February 2023

Abstract. Lukman, Dinarti D, Siregar UJ, Turjaman M, Sudarsono. 2023. Isolation and molecular identification of agarwood-inducing fungi and their virulence test using Aquilaria sp. seedlings. Biodiversitas 24: 140-148. Agarwood is a lump of fragrant resin with a dark color and distinctive aroma from secondary metabolite products that accumulate in wood fibers produced from the genus Aquilaria and Gyrinops, a plant defense mechanism against damage caused by wounds and infection of specific fungal pathogens. The three main factors in producing agarwood sapwood are the presence of plants that have the potential to produce agarwood (family Thymelaceae) as a host, a supportive environment, and the presence of specific fungal pathogens. The isolation, identification, and virulence testing of local isolates must be made to get the correct agarwood-inducing pathogens without posing potential environmental problems. A total of five explants of Aquilaria sp. branches producing agarwood from the study site were used. This study aims to isolate local strains of fungi associated with agarwood formation from North Aceh regency, Aceh province, Indonesia, figure out their virulence against and ability to induce agarwood from seedlings of target trees, and determine their species identity. The experiments comprised isolation, macroscopic and microscopic identification, virulence tests, and species identification based on ITS sequences. The study resulted in five local Aceh isolates (LAI-1- LAI-5). Four isolates (LAI-1 - LAI-4) can induce agarwood formation, and oneisolate (LAI-5) is a white rot fungus. The ITS sequence analysis showed that LAI-1 - LAI-4 were Fusarium solani, while two colonies taken from LAI-5 isolate were identified as Ceriporia lacerataor Irpex laceratus (LAI-5 colony#1), and Daldinia eschscholtzii (LAI-5 colony #3). Based on these findings, the LA-5 isolate was probably a mixture of the two white rot fungus isolates.