bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risky (information) business: an informational risk research agenda
Authors: Hicks Alison 
Published: February 2023

PurposeThe purpose of this conceptual paper is to suggest that the growing sociocultural theorisation of risk calls for a more robust research focus on the role that information and in particular, information literacy, plays in mediating hazards and danger.Design/methodology/approachStarting by tracing how information has been conceptualised in relation to risk through technoscientific, cognitive and sociocultural lenses, the paper then focuses on emerging sociocultural understandings of risk to present a research agenda for a renewed sociocultural exploration of how risk is shaped through the enactment of information literacy.FindingsThe paper identifies and examines how information literacy shapes four key aspects of risk, including risk perception, risk management, risk-taking and “at-risk” populations. These four aspects are further connected through broader themes of learning, identity, work and power, which form the basis of the sociocultural risk research agenda.Originality/valueThis paper is the first study bringing together the many understandings related to how risk is informed and establishes risk as a key area of interest within information literacy research.
Revenue composition and financial health of nonprofit humanitarian and emergency health services
Authors: Tariq Syed , Zaffar Muhammad Adeel , Riaz Yasir , Jalil Muhammad Naiman 
Published: February 2023

PurposeEmergency health and humanitarian nonprofits work under volatile circumstances that strain nonprofits' financial resources. This study investigates the impact of revenue composition on the financial health of these nonprofits and the impact of financial health on the likelihood of financial distress.Design/methodology/approachA sample of 11,335 emergency nonprofits from 2003 to 2020 was obtained through form 990 data and studied through a difference generalized method of moments (GMM) approach for the impact of revenue composition on financial health. The impact of financial health on financial distress was studied through panel logistics regression.FindingsRevenue diversification adversely affects the financial health of nonprofit emergency health and humanitarian organizations contrary to the implications of modern portfolio theory. The financial health of nonprofit emergency health and humanitarian organizations is persistent through the significant positive effect of lags in most cases.Originality/valueThe emergency health subsector of nonprofits was studied separately due to the unique nature of the sectors' operations and operating environment. The impact of revenue composition was investigated on key dimensions of financial health. Omitted variable bias, simultaneity and dynamic endogeneity were handled through difference GMM.
Disclosing value creation in integrated reports according to the six capitals: a holistic approach for a holistic instrument
Authors: Pigatto Giacomo , Cinquini Lino , Tenucci Andrea , Dumay John 
Published: February 2023

Purpose
This study is an analysis that aims to understand the rationale behind the concept of value creation contained in the integrated reporting (IR) framework. As such, the authors examined the quality of the disclosures made in integrated reports by measuring the level to which the six capitals (6Cs) have been integrated into disclosures on value creation.

Design/methodology/approach
The IR framework’s value creation model focuses on six content elements and three guiding principles. Hence, the present analysis combines content analysis with quantitative measures in the form of a bespoke Integrated Disclosure Index. The index measures the level of integration found in the disclosures instead of the mere presence or absence of mentioned capitals, content elements and guiding principles in isolation. The present sample comprised the 2016 integrated/sustainability reports for 184 listed companies sourced from the Integrated Reporting Examples Database.

Findings
The 6Cs are well disclosed in form but only partially disclosed in substance. Further, overall levels of integration between the capitals, the content elements and the guiding principles are higher than average. Disclosures on materiality, business models and stakeholder relationships are somewhat lacking, as are the related medium- and long-term disclosures on outlook.

Practical implications
The paper contributes to the academic debate on IR by building a case for holistically assessing the substance of integrated reports. Considering that the IR value creation model can underpin and align with the 17 UN sustainable development goals, the authors show how the fundamental concept of the 6Cs sustaining value creation is understood and implemented differently across the various elements and principles of the IR framework.

Social implications
This research also provides guidance for overcoming some of the practical hurdles associated with assessing the quality of reports because the authors provide tools for spotlighting the substance of disclosures over their form.

Originality/value
This paper delves into the substance of integrated reports by assessing how well the 6Cs have been integrated into disclosures on the content elements and guiding principles of the IR framework. In contrast to previous IR research that has mainly analysed capital, elements and principles in isolation, the authors develop an index assessing the integration of these three fundamental concepts of IR.
First report on the occurrence of Vibrio cholerae nonO1/nonO139 in natural and artificial lakes and ponds in Serbia: Evidence for a long‐distance transfer of strains and the presence of Vibrio paracholerae
Authors: Rehm Carmen , Lippert Kathrin , Indra Alexander , Kolarević Stoimir , Kračun‐Kolarević Margareta , Leopold Melanie , Steinbacher Sophia , Schachner Iris , Campostrini Lena , Risslegger Alexandra , Farnleitner Andreas H. , Kolm Claudia , Kirschner Alexander K.T. 
Published: February 2023

AbstractVibrio cholerae are natural inhabitants of specific aquatic environments. Strains not belonging to serogroups O1 and O139 are usually unable to produce cholera toxin and cause cholera. However, non‐toxigenic V. cholerae (NTVC) are able to cause a variety of mild‐to‐severe human infections (via seafood consumption or recreational activities). The number of unreported cases is considered substantial, as NTVC infections are not notifiable and physicians are mostly unaware of this pathogen. In the northern hemisphere, NTVC infections have been reported to increase due to global warming. In Eastern Europe, climatic and geological conditions favour the existence of inland water‐bodies harbouring NTVC. We thus investigated the occurrence of NTVC in nine Serbian natural and artificial lakes and ponds, many of them used for fishing and bathing. With the exception of one highly saline lake, all investigated water‐bodies harboured NTVC, ranging from 5.4 × 101 to 1.86 × 104 CFU and 4.5 × 102 to 5.6 × 106 genomic units per 100 ml. The maximum values observed were in the range of bathing waters in other countries, where infections have been reported. Interestingly, 7 out of 39 fully sequenced presumptive V. cholerae isolates were assigned as V. paracholerae, a recently described sister species of V. cholerae. Some clones and sublineages of both V. cholerae and V. paracholerae were shared by different environments indicating an exchange of strains over long distances. Important pathogenicity factors such as hlyA, toxR, and ompU were present in both species. Seasonal monitoring of ponds/lakes used for recreation in Serbia is thus recommended to be prepared for potential occurrence of infections promoted by climate change‐induced rise in water temperatures.
The skin microbiome in the first year of life and its association with atopic dermatitis
Authors: Rapin Alexis , Rehbinder Eva Maria , Macowan Matthew , Pattaroni Céline , Lødrup Carlsen Karin C. , Harris Nicola L. , Jonassen Christine M. , Landrø Linn , Lossius Astrid H. , Nordlund Björn , Rudi Knut , Skjerven Håvard O. , Cathrine Staff Anne , Söderhäll Cilla , Ubags Niki , Vettukattil Riyas , Marsland Benjamin J. 
Published: February 2023

AbstractBackgroundEarly‐life microbial colonization of the skin may modulate the immune system and impact the development of atopic dermatitis (AD) and allergic diseases later in life. To address this question, we assessed the association between the skin microbiome and AD, skin barrier integrity and allergic diseases in the first year of life. We further explored the evolution of the skin microbiome with age and its possible determinants, including delivery mode.MethodsSkin microbiome was sampled from the lateral upper arm on the first day of life, and at 3, 6, and 12 months of age. Bacterial communities were assessed by 16S rRNA gene amplicon sequencing in 346 infants from the PreventADALL population‐based birth cohort study, representing 970 samples. Clinical investigations included skin examination and skin barrier function measured as trans‐epidermal water loss (TEWL) at the site and time of microbiome sampling at 3, 6, and 12 months. Parental background information was recorded in electronic questionnaires, and delivery mode (including vaginal delivery (VD), VD in water, elective caesarean section (CS) and emergency CS) was obtained from maternal hospital charts.ResultsStrong temporal variations in skin bacterial community composition were found in the first year of life, with distinct patterns associated with different ages. Confirming our hypothesis, skin bacterial community composition in the first year of life was associated with skin barrier integrity and later onsets of AD. Delivery mode had a strong impact on the microbiome composition at birth, with each mode leading to distinct patterns of colonization. Other possible determinants of the skin microbiome were identified, including environmental and parental factors as well as breastfeeding.ConclusionSkin microbiome composition during infancy is defined by age, transiently influenced by delivery mode as well as environmental, parental factors and breastfeeding. The microbiome is also associated with skin barrier integrity and the onset of AD.
The MAEL expression in mitochondria of human spermatozoa and the association with asthenozoospermia
Authors: Cheng Yu‐Sheng , Chen Hsing‐Yi , Lin Yu‐Chiao , Lin Yi‐Syuan , Yeh Yi‐Chun , Yeh Yi‐Hsuan , Cheng Yung‐Hsuan , Lin Yung‐Ming , Weng Han‐Yu , Lin Tsung‐Yen , Lin Shih‐Chieh 
Published: February 2023

AbstractPurposeThe maelstrom spermatogenic transposon silencer (MAEL) function in postmeiotic germ cells remains unclear, and its protein localization in human testis and spermatozoa awaits determination. This study aims to clarify the MAEL expression in human spermatogenesis and to explore its role in sperm function.Materials and methodsTwenty‐seven asthenozoospermic men, 40 normozoospermic controls, and three obstructive azoospermic men were enrolled. The transcripts of MAEL in the seminiferous epithelium and MAEL downstream targets were identified by bioinformatics analysis. MAEL protein expression in human testis and ejaculated sperms were examined by immunohistochemical and immunogold staining, respectively. The roles of MAEL in mitochondria function were investigated by siRNA knockdown in human H358 cells. The association between MAEL protein levels and clinical sperm features was evaluated.ResultsAbundant MAEL was expressed in spermatid and spermatozoa of the human testis. Remarkably, MAEL was located in the mitochondria of ejaculated sperm, and bioinformatics analysis identified GPX4 and UBL4B as MAEL's downstream targets. Knockdown of MAEL sabotaged mitochondria function and reduced adenosine triphosphate (ATP) production in H358 cells. MAEL, GPX4, and UBL4B expression levels were significantly decreased in asthenozoospermic sperms than in controls. The MAEL protein levels were positively correlated with GPX4 and UBL4B in human sperm. Total motile sperm count (TMSC) was positively correlated with protein levels of MAEL, GPX4, and UBL4B in ejaculated sperms.ConclusionsWe highlight prominent MAEL expression in the intratesticular spermatid and the mitochondria of ejaculated spermatozoa. MAEL directly binds to GPX4 and UBL4B, and loss of MAEL induces mitochondrial dysfunction. MAEL‐mitochondrial function‐motility relationship might advance our understanding of the causes of asthenozoospermia.
Simulating peers: Can puppets simulate peer interactions in studies on children's socio‐cognitive development?
Authors: Stengelin Roman , Haun Daniel B. M. , Kanngiesser Patricia 
Published: February 2023

AbstractInteractions with peers are fundamental to socio‐cognitive development, but assessing peer interactions in standardized experiments is challenging. Therefore, researchers commonly utilize puppetry to simulate peers. This Registered Report investigated urban German children's (AgeRange = 3.5–4.5 years; N = 144; 76♀) mind ascriptions and social cognition to test whether they treat puppets like peers, adults, or neither. Children attributed less mind properties to puppets than peers or adults. However, children's social cognition (i.e., normativity, prosociality, and theory of mind) varied little across partners. Puppetry relies on children's ability for pretense, but can provide valid insights into socio‐cognitive development. Implications for using puppets as stand‐ins for peers in developmental research are discussed.
Behavioural and cognitive‐behavioural theories in oral health research: Current state and future directions
Authors: McNeil Daniel W. 
Published: February 2023

AbstractObjectivesBehavioural and cognitive‐behavioural theories, models and frameworks have been incorporated for decades in behavioural and social oral health sciences, oral health care, and education of dentists, hygienists, and other oral healthcare professionals.MethodsWhile a myriad of these conceptualizations have been incorporated in this work, there are six of them that have had the greatest impact in the oral health arena: (a) Health Belief Model; (b) Theory of Reasoned Action, Theory of Planned Behavior and Integrated Behavioral Model, which are considered in unison; (c) Social Learning Theory and Social Cognitive Theory which are considered together; (d) Transtheoretical Model/Stages of Change Model; (e) Salutogenesis Model/Theory and Sense of Coherence Framework; and the (f) Behavior Change Wheel, Capability‐Opportunity‐Motivation‐Behavior Model and Theoretical Domains Framework, which are categorized together.ResultsAn analysis of nomenclature (i.e. theories, models, frameworks and conceptualizations) is provided in the context of a description of each of these theories and models, with discussion about their aspects that particularly relate to oral health. Additionally, a quantitative, longitudinal view is provided of the frequency of use of these theories and models in the oral health arena. Given the benefits of theory‐based intervention development, dissemination and implementation, it is important to consider these theories and models in a collective context.ConclusionsAt a basic level, these theories and models help in identifying and acting on mechanisms, both of behaviour itself and behaviour change. Future directions are discussed in terms of need for theory evolution and development.
The hybrid protein BTH2 suppresses allergic airway inflammation in a murine model of HDM‐specific immunotherapy
Authors: da Silva Eduardo Santos , de Santana Marina Borges Rabelo , Silveira Elisânia Fontes , Torres Rogério Tanan , Silva Raphael Chagas , Fernandes Antônio Márcio Santana , Belitardo Emília Maria Medeiros de Andrade , Garcés Luis Fabián Salazar , Santiago Leonardo Freire , Urrego Juan Ricardo , Vilas‐Bôas Deise Souza , de Freitas Luiz Antônio Rodrigues , Zakzuk Josefina , Pacheco Luis Gustavo Carvalho , Cruz Álvaro Augusto , Ferreira Fatima , Cooper Philip , Caraballo Luis , Pinheiro Carina da Silva , Alcantara‐Neves Neuza Maria 
Published: February 2023

AbstractBackgroundAllergen‐specific immunotherapy (AIT) is the only disease‐modifying treatment approach to change disease‐causing allergens. Hypoallergenic derivatives show promise as potential therapeutics, amongst which BTH2 was designed to induce tolerance against Blomia tropicalis allergy. Our aim was to investigate the hypoallergenicity and immunoregulatory activity of BTH2 in vitro and its therapeutic potential in a mouse model of AIT.MethodsRecombinant Blo t 5 and Blo t 21 allergens and their hybrid derivatives (BTH1 and BTH2) were expressed and purified. IgE binding capacity was tested by ELISA using sera from Brazilian, Colombian, and Ecuadorian subjects. Secretion of cytokines in supernatants from human cell cultures was measured following stimulation with the four recombinants and controls. The capacity of BTH2 to ameliorate allergic airway inflammation induced by B. tropicalis extract was evaluated in a murine model of AIT.ResultsrBlo t 5 and rBlo t 21 were identified as major allergens in Latin American patients, and BTH2 had the lowest IgE binding. In vitro stimulation of human cells induced greater levels of IL‐10 and IFN‐γ and reduced the secretion of Th2 cytokines. BTH2 ameliorated allergic airway inflammation in B. tropicalis‐challenged A/J mice, as evidenced by the histopathological and humoral biomarkers: decreased Th2 cytokines and cellular infiltration (especially eosinophils), lower activity of eosinophil peroxidase, an increase in IgG blocking antibodies and strong reduction of mucus production by goblet cells.ConclusionsOur study shows that BTH2 represents a promising candidate for the treatment of B. tropicalis allergy with hypoallergenic, immune regulatory and therapeutic properties. Further pre‐clinical studies are required in murine models of chronic asthma to further address the efficacy and safety of BTH2 as a vaccine against B. tropicalis‐induced allergy.
Peracetic acid bleaching of banana fibre: Process optimisation
Authors: Chattopadhyay S. N. , Samanta Kartick K. , Ammayappan L. , Ghosh R. K. 
Published: February 2023

AbstractBanana is an important commercially available natural fibre, suitable for making coarse yarns. It has also potential for making fine home and apparel textiles after requisite chemical intervention or blending with other fine fibres. For making such products, chemical processing, namely bleaching, coloration and finishing, play an important role. Bleaching of fibre is generally carried out in highly alkaline condition and at high temperature of 85°C using hydrogen peroxide to achieve whiteness index of > 70 with about 25% loss in tensile strength. To achieve a similar whiteness index, while addressing strength loss, a fibre friendly low‐temperature low‐alkali based peracetic acid (PAA) bleaching of banana fibre has been proposed in the present article. Important bleaching process parameters, namely PAA concentration (10–30 g/L), time (60–180 min) and temperature (60–80°C), have been varied for optimisation of the bleaching process. Banana fibre bleaching using PAA concentration of 20 g/L at 70°C for 2 h can produce fibre with whiteness index of > 70, which is suitable for subsequent coloration. The PAA bleached banana fibre can retain 84% of its bundle strength and 95.6% of its weight. Physical (strength, fineness), chemical (attenuated total reflectance Fourier‐transform infrared [ATR‐FTIR], energy dispersive X‐ray spectroscopy [EDX]), optical (colour) and morphological (scanning electron microscopy [SEM]) properties of banana fibres before and after bleaching were evaluated to study the efficacy of the process.
Phase 2 trial in acetylcholine receptor antibody‐positive myasthenia gravis of transition from intravenous to subcutaneous immunoglobulin: The MGSCIg study
Authors: Pasnoor Mamatha , Bril Vera , Levine Todd , Trivedi Jaya , Silvestri Nicholas J. , Phadnis Milind , Katzberg Hans D. , Saperstein David S. , Wolfe Gil I. , Herbelin Laura , Higgs Kiley , Heim Andrew J. , Statland Jeffrey M. , Barohn Richard J. , Dimachkie Mazen M. 
Published: February 2023

AbstractBackground and purposeData on maintenance therapy with subcutaneous immunoglobulin (SCIg) in myasthenia gravis (MG) are limited. We report on transitioning acetylcholine receptor (AChR) antibody‐positive (Ab+) MG patients on stable intravenous immunoglobulin (IVIg) regimens as part of routine clinical care to SCIg 1:1.2.MethodsThis multicenter North American open‐label prospective investigator‐initiated study had two components: the IVIg Stabilization Period (ISP) enrolling patients already on IVIg as part of routine clinical care (Weeks −10 to −1), followed by transition of stable MG subjects to SCIg in the Experimental Treatment Period (ETP; Weeks 0 to 12). We hypothesized that >65% of patients entering the ETP would have a stable Quantitative Myasthenia Gravis (QMG) score from Week 0 to Week 12. Secondary outcome measures included other efficacy measures, safety, tolerability, IgG levels, and treatment satisfaction.ResultsWe recruited 23 patients in the ISP, and 22 entered the ETP. A total of 12 subjects (54.5%) were female, and 18 (81.8%) were White, with mean age 51.4 ± 17 years. We obtained Week 12 ETP QMG data on 19 of 22; one subject withdrew from ETP owing to clinical deterioration, and two subjects withdrew due to dislike of needles. On primary analysis, 19 of 22 participants (86.4%, 95% confidence interval = 0.72–1.00) were treatment successes using last observation carried forward (p = 0.018). Secondary efficacy measures supported MG stability. SCIg was safe and well tolerated, and IgG levels were stable. Treatment satisfaction was comparable between ISP and ETP.ConclusionsMG patients on IVIg as part of their routine clinical care remained stable on monthly IVIg dosage, and most maintained similar disease stability on SCIg.