bluuebunny/crossref_metadata_2025_split huggingface dataset:
Formability prediction of high‐strength steel sheet using experimental, analytical and theoretical analysis based on strain and stress forming limit curves and its application to automotive forming parts
Authors: Nakwattanaset A. , Panich S. , Suranuntchai S. 
Published: September 2023

AbstractIn this work, the high‐strength steel (HSS) sheet dual‐phase 440 (DP440) were conducted to establish the forming limit curve (FLC) and analytical forming limit stress curve (FLSC) obtained from experimental forming limit curve. First, the Nakajima stretch forming examination was carried out to obtain forming limit curve of investigated sheet. Afterwards, the theoretical Marciniak–Kuczinsky (M–K) model was developed and calculated to evaluate localized necking limits both in strain and stress spaces combination with anisotropic yield criteria. Then, the analytical forming limit stress curves were plastically calculated by using experimental forming limit curve data combination with Swift hardening model and anisotropic yield criteria namely, Hill’48 and Yld2000‐2d for representing anisotropic plastic deformation behavior on examined steel sheet. Finally, automotive stamping parts were performed in order to verify an applicability of all developed curves. It was observed that the analytical forming limit stress curves could more precisely predict the formability of automotive parts better than the forming limit curve based on strain. Particularly, the one based on Yld2000‐2d predict better than the one based on Hill’48. Simultaneously, the experimental forming limit curve and analytical forming limit stress curve were also evaluated comparing with the theoretical calculated forming limit curve and forming limit stress curve using the Marciniak–Kuczinsky model. It should be noted again that the experimental forming limit curve and analytical forming limit stress curve are the best one. Therefore, the Yld2000‐2d yield function better represented the anisotropic behavior of the high‐strength steel sheet dual‐phase 440 than Hill′ 48 yield function, and can suitable be used for the analysis prediction and design of bumper automotive parts under forming processes.
The JAK3Q988P mutation reveals oncogenic potential and resistance to ruxolitinib
Authors: Lahera Antonio , Vela‐Martín Laura , Fernández‐Navarro Pablo , Llamas Pilar , López‐Lorenzo José L. , Cornago Javier , Santos Javier , Fernández‐Piqueras José , Villa‐Morales María 
Published: September 2023

AbstractT‐cell acute lymphoblastic leukemia (T‐ALL) arises from the malignant transformation of T‐cell progenitors at various differentiation stages. Given that patients who relapse have a dismal prognosis, there is an urgent need to identify the molecular alterations that are present in such patients and promote leukemogenesis to implement personalized therapies with higher efficacy and fewer adverse effects. In the present manuscript, we identified the JAK3Q988P mutation in a T‐ALL patient who did not achieve a durable response after the conventional treatment and whose tumor cells at relapse presented constitutive activation of the JAK/STAT pathway. Although JAK3Q988P has been previously identified in T‐ALL patients from different studies, the functional consequences exerted by this mutation remain unexplored. Through the combination of different hematopoietic cellular models, we functionally characterize JAK3Q988P as an oncogenic mutation that contributes to leukemogenesis. Notably, JAK3Q988P not only promotes constitutive activation of the JAK/STAT pathway in the absence of cytokines and growth factors, as is the case for other JAK3 mutations that have been functionally characterized as oncogenic, but also functions independently of JAK1 and IL2RG, resulting in high oncogenic potential as well as resistance to ruxolitinib. Our results indicate that ruxolitinib may not be efficient for future patients bearing the JAK3Q988P mutation who instead may obtain greater benefits from treatments involving other pharmacological inhibitors such as tofacitinib.
Efficacy of educational instructions on pelvic floor muscle training in the treatment of urinary incontinence: Systematic review and meta‐analysis
Authors: Leite Alana Mirelle Coelho , de Araújo Rodrigo Cappato , Santos Ana Vitória Rodrigues dos , Barbosa Sháyra Anny Moura , Amorim Danielly Alves , da Sena Fraga Chalana Duarte , Pitangui Ana Carolina Rodarti 
Published: September 2023

AbstractObjectiveThe present study aimed to investigate the efficacy of educational interventions on pelvic floor (PF) muscle training in the treatment of urinary incontinence (UI).MethodsThis is a systematic review of literature with meta‐analysis, performed according to the Preferred Reporting Items for Systematic Reviews and Meta‐Analysis (PRISMA). To do so, randomized clinical trials that performed educational interventions of PF, UI, and developed the training of PF muscles (TPFM) for incontinent women, performing group or individual comparisons, with control and experimental groups or with two or more experimental groups were selected. The search for papers was performed in the following databases: PubMed, Scopus, Embase, Web of Science, and SciELO, no specific publication date was chosen. The risk of bias was performed using the PEDro scale and the quality of the evidence was performed using GRADE.ResultsThe review included six studies with 1003 participants. Most studies presented 5−8 points regarding risk of bias. Most of the studies were performed in the last 5 years, with women of various ages, high educational level and prevalence of UI of effort. The present study showed that offering educational instructions and guiding women on TPFM was capable of reducing urinary symptoms. When compared to control, significant between‐group differences were found in the studies, in which the control group did not receive any kind of instructions or treatment (p < 0.05). The use of technologies through mobile apps was efficient in the treatment of incontinent women (p < 0.05). Performing TPFM individually or in groups did not present differences in the results, with both improving urinary symptoms. The meta‐analysis presented a mean effect and a clinically important difference in three studies.ConclusionThe interventions involving instructions to TPFM associated to health education brought improvements to urinary symptoms.
Anesthesia‐related brain microstructure modulations detected by diffusion magnetic resonance imaging
Authors: Lindhardt Thomas Beck , Skoven Christian Stald , Bordoni Luca , Østergaard Leif , Liang Zhifeng , Hansen Brian 
Published: September 2023

AbstractRecent studies have shown significant changes to brain microstructure during sleep and anesthesia. In vivo optical microscopy and magnetic resonance imaging (MRI) studies have attributed these changes to anesthesia and sleep‐related modulation of the brain's extracellular space (ECS). Isoflurane anesthesia is widely used in preclinical diffusion MRI (dMRI) and it is therefore important to investigate if the brain's microstructure is affected by anesthesia to an extent detectable with dMRI. Here, we employ diffusion kurtosis imaging (DKI) to assess brain microstructure in the awake and anesthetized mouse brain (n = 22). We find both mean diffusivity (MD) and mean kurtosis (MK) to be significantly decreased in the anesthetized mouse brain compared with the awake state (p < 0.001 for both). This effect is observed in both gray matter and white matter. To further investigate the time course of these changes we introduce a method for time‐resolved fast DKI. With this, we show the time course of the microstructural alterations in mice (n = 5) as they transition between states in an awake‐anesthesia‐awake paradigm. We find that the decrease in MD and MK occurs rapidly after delivery of gas isoflurane anesthesia and that values normalize only slowly when the animals return to the awake state. Finally, time‐resolved fast DKI is employed in an experimental mouse model of brain edema (n = 4), where cell swelling causes the ECS volume to decrease. Our results show that isoflurane affects DKI parameters and metrics of brain microstructure and point to isoflurane causing a reduction in the ECS volume. The demonstrated DKI methods are suitable for in‐bore perturbation studies, for example, for investigating microstructural modulations related to sleep/wake‐dependent functions of the glymphatic system. Importantly, our study shows an effect of isoflurane anesthesia on rodent brain microstructure that has broad relevance to preclinical dMRI.
Energy expenditure deficits drive obesity in a mouse model of Alström syndrome
Authors: Stephenson Erin J. , Kinney Clint E. , Stayton Amanda S. , Han Joan C. 
Published: September 2023

AbstractObjectiveAlström syndrome (AS) is a rare multisystem disorder of which early onset childhood obesity is a cardinal feature. Like humans with AS, animal models with Alms1 loss‐of‐function mutations develop obesity, supporting the notion that ALMS1 is required for the regulatory control of energy balance across species. This study aimed to determine which component(s) of energy balance are reliant on ALMS1.MethodsComprehensive energy balance phenotyping was performed on Alms1tvrm102 mice at both 8 and 18 weeks of age.ResultsIt was found that adiposity gains occurred early and rapidly in Alms1tvrm102 male mice but much later in females. Rapid increases in body fat in males were due to a marked reduction in energy expenditure (EE) during early life and not due to any genotype‐specific increases in energy intake under chow conditions. Energy intake did increase in a genotype‐specific manner when mice were provided a high‐fat diet, exacerbating the effects of reduced EE on obesity progression. The EE deficit observed in male Alms1tvrm102 mice did not persist as mice aged.ConclusionsEither loss of ALMS1 causes a developmental delay in the mechanisms controlling early life EE or activation of compensatory mechanisms occurs after obesity is established in AS. Future studies will determine how ALMS1 modulates EE and how sex moderates this process.
Numerical accuracy of principal geodesic analysis on the sphere in director‐based dynamics of hybrid mechanical systems
Authors: Schubert Jenny , Steinbach Marc C. 
Published: September 2023

AbstractWe aim at nonlinear model order reduction (MOR) in hybrid mechanical systems by means of Principal Geodesic Analysis (PGA) on the Riemannian manifolds S2 (the sphere) and SO(3) (the rotation group). MOR requires highly accurate and efficient implementations of the logarithm maps and the resulting lifts across multiple branches. However, in our cases these maps have singularities due to periodicity. In this work we focus on the logarithm and lift maps for the sphere S2. We conduct detailed numerical experiments on mechanical systems to achieve maximal accuracy in spite of the singularities.
An approach for improving SHM systems with GUW detection and embedded sensors by a planar gradient acoustic impedance matching
Authors: Rottmann Max , Weber Wolfgang E. 
Published: September 2023

AbstractFor technical structures, such as airplanes, the service life must be increased to satisfy the requirements for high efficiency in terms of costs and sustainability. Monitoring the system's current health and providing solutions to maintain it reliably is one way to accomplish this objective. A structural health monitoring system, in which actuators induce a guided ultrasonic wave or wavefield monitored by a sensor or a network of sensors, is a standard for thin‐walled structures, which are made of, for example, fibre‐metal‐laminates. The sensor measurements provide information that can be used to determine the respective health state of the system. However, embedding the actuator and sensors in the system typically results in a distortion of the wavefield, for example, mode‐conversion and reflections. The distortion can lead to over‐ or underestimation of the quantity, location and severity of the damage. Due to these false detections, both an unnecessary high effort for retrofitting the structure and a reduction of the structure's technical reliability may be needed. The objective of the current contribution is to reduce the wave‐field distortion/reflections caused by the sensors to prevent or minimise these false detections. To reduce the distortion and reflection of the wavefield, a functionally graded material with an acoustic impedance matching based on a mechanical model is used. In order to control and adjust the acoustic impedance, which is the leading parameter concerning distortion and reflections of waves, tungsten particles were added to the uncured epoxy resin. The design of an interphase between the sensor or its glass housing and the surrounding structure is achieved by this novel approach. The interphase properties are varying in the radial direction to the sensor and are depending on the tungsten particle content in the epoxy resin. In this work, several models regarding the radial distribution of the tungsten particle content and the excitation frequency are investigated. Additionally, the dependence on geometrical influence is also addressed. The approach results, for specific configurations, in (i) reduced reflections from the sensor (less distortion) and (ii) amplified measuring signals of the sensor. Numerous numerical examples demonstrate the benefit of the presented approach.
Release of ‘UI Gold’ hard white spring wheat
Authors: Chen Jianli , Wheeler Justin J. , Marshall Juliet M. , Chen Xianming , Windes Sarah , Wilson Cathy , Su Meng , Yimer Belayneh , Schroeder Kurtis , Jackson Chad 
Published: September 2023

Abstract‘UI Gold’ (Reg. no. CV‐1205, PI 700874) hard white spring wheat (Triticum aestivum L.) was developed by the Idaho Agricultural Experiment Station and released in 2022. UI Gold was derived from the cross A03018S‐E × WA8123. It was tested under experimental numbers A11434‐14 and IDO1804S and showed high grain yield and excellent bread‐baking quality when grown in both irrigated and dryland conditions. UI Gold has grain yield comparable to the high‐yielding hard white spring check cultivar ‘Dayn’ and higher yield than the widely grown hard white spring wheat cultivars ‘SY Teton’ and ‘UI Platinum’. UI Gold has gluten strength similar to SY Teton and greater gluten strength than Dayn and UI Platinum. Compared with Dayn, in various trials UI Gold matured 3–4 days later and was 1–5 cm shorter.
Immune capture and protein profiling of small extracellular vesicles from human plasma
Authors: Skoczylas Łukasz , Gawin Marta , Fochtman Daniel , Widłak Piotr , Whiteside Theresa L. , Pietrowska Monika 
Published: September 2023

AbstractExtracellular vesicles (EVs), the key players in inter‐cellular communication, are produced by all cell types and are present in all body fluids. Analysis of the proteome content is an important approach in structural and functional studies of these vesicles. EVs circulating in human plasma are heterogeneous in size, cellular origin, and functions. This heterogeneity and the potential presence of contamination with plasma components such as lipoprotein particles and soluble plasma proteins represent a challenge in profiling the proteome of EV subsets by mass spectrometry. An immunocapture strategy prior to mass spectrometry may be used to isolate a homogeneous subpopulation of small EVs (sEV) with a specific endocytic origin from plasma or other biofluids. Immunocapture selectively separates EV subpopulations in biofluids based on the presence of a unique protein carried on the vesicle surface. The advantages and disadvantages of EV immune capture as a preparative step for mass spectrometry are discussed.
Model‐Independent Study for a Quintessence Model of Dark Energy: Analysis and Observational Constraints
Authors: Bouali Amine , Chaudhary Himanshu , Mehrotra Amritansh , Pacif Shibesh Kumar Jas 
Published: September 2023

AbstractIn this paper, a well‐motivated parameterization of the Hubble parameter (H) is revisited that renders two models of dark energy showing some intriguing features of the late‐time accelerating Universe. A general quintessence field is considered as a source of dark energy. Tighter constraints using recently updated cosmic observational datasets for the considered models have been obtained. The two models described here show a nice fit to the considered uncorrelated Hubble datasets, Standard candles, Gamma Ray Bursts, Quasars, and uncorrelated Baryonic Acoustic Oscillations datasets. Using the constrained values of the model parameters, some features of the late‐time accelerating models and obtained the present value of the deceleration parameter (q0), the present value of the Hubble parameter (H0) and the transition redshift () from deceleration to acceleration have been discussed. The current value of the deceleration parameter for both models is consistent with the Planck 2018 results. The evolution of the geometrical and physical parameters is discussed through graphical representations for both models with some diagnostic analysis. The statistical analysis performed here shows greater results and overall, the outcomes of this investigation are superior to those previously found.
The association between beta‐blockers use and prostate cancer mortality: A mini systematic review and meta‐analysis
Authors: Uleri Alessandro , Baboudjian Michael , Tedde Alessandro , Rajwa Pawel , Pradere Benjamin , Gallioli Andrea , Breda Alberto , Ploussard Guillaume 
Published: September 2023

AbstractBackgroundPreclinical studies have shown that the sympathetic nervous system is involved in the development of metastases, suggesting a potential antitumor effect of beta‐blockers. These findings sparked a controversy over the past decade regarding the direction of the association between beta‐blocker use and prostate cancer (PCa) mortality. To investigate this association, we conducted a systematic review and meta‐analysis.MethodsThe review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta‐analyses guidelines to identify eligible studies. The primary outcome was PCa mortality in beta‐blocker users versus nonusers, and overall survival was studied as a secondary endpoint. We assessed heterogeneity using the Cochrane Q test and quantified it using I2 values. In the case of heterogeneity (Cochrane Q test p < 0.05 and I2 > 50%), random‐effect models were used to determine the association between beta‐blockers use and survival outcomes.ResultsTen studies met our inclusion criteria and a total of 74,970 patients were included: 26,674 beta‐blocker users and 48,326 nonusers.There was no statistically significant association between beta‐blocker exposure and PCa mortality (hazard ratio [HR] 0.97; 95% confidence interval [CI] 0.87–1.09; p = 0.61). However, significant heterogeneity was found. Meta‐regression analysis to explain heterogeneity showed no effect of any of the variables assessed (country, percentage of beta‐blocker users, type of beta‐blocker [selective and nonselective], study period, PCa stage and follow‐up duration; all p > 0.05). We found similar results when we restricted the analysis to studies that include only patients with advanced PCa (HR 0.92; 95% CI 0.80–1.06; p = 0.24). Similarly, we found no association with overall survival (HR 1.02; 95% CI 0.94–1.10; p = 0.64). Meta‐regression analysis was also performed, but none of the variables assessed explained the observed heterogeneity (all p > 0.05).ConclusionsWe found no association between beta‐blockers use and overall survival or PCa mortality. This meta‐analysis, which includes a considerable population and the most recent literature, provides important data for routine clinical care and patient counseling.
Trophic niche isotope analysis of the fish assemblages in a subtropical river, Southern China
Authors: Chen Gang , Xiong Weifeng , Zhou Hui , Zhang Jiandong , Zhang Man , Li Yuncong , Gu Binhe 
Published: September 2023

AbstractFreshwater fishery resources in Chinese rivers have been markedly impaired as the results of overfishing, damming, and watershed development. However, little is known about trophic ecology of fish assemblages in the rivers of China. In this study, fishes were collected from an upstream, midstream, and downstream site of the Moyangjiang River, Southern China, to investigate trophic niche structure using stable isotope analysis. We calculated several trophic niche metrics using δ13C and δ15N ratios of the fish assemblages at each study site. Results showed no significant differences in the δ13C ratios between the pelagic and benthic fish assemblages at each study site. This suggests a homogenous dietary base shared by all fish at each site, likely as the result of continuous water column mixing in this shallow and fast‐moving river. The upstream fish assemblage had the greatest species abundance and trophic diversity. The fish assemblage at the midstream site displayed the smallest trophic niche space (total area of the δ13C and δ15N bi‐plot space) and trophic diversity. The midstream site also showed the most depleted 13C, suggesting a more degraded habitat compared with the other two study sites. The fish assemblages at the downstream site displayed the greatest basal resource diversity, largest CR, and trophic niche space and trophic diversity. However, the fish assemblage at the downstream site also displayed the lowest species abundance, redundancy, and evenness of trophic spacing. These findings suggest that the trophic niche of the fish assemblage at the downstream site, which received resources from upstream flow, experienced greater watershed development and greater in situ production, demonstrating positive and negative impacts by anthropogenic activities. Future studies should also gather information on fish production, watershed development, and water quality, to aid in the interpretation of the stable isotope analysis of fish trophic niches.
Tracking endolithic microbiomes to support the sustainability and functioning of global drylands
Authors: Coleine Claudia , Egidi Eleonora , Delgado‐Baquerizo Manuel , Selbmann Laura 
Published: September 2023

AbstractDrylands cover almost half of the planet and support >25% the global population. In this era of global warming, they are expected to continue expanding by the end of the century as a consequence of predicted increases in aridity, which will affect multiple global locations that are already characterised by extreme temperatures, low and variable rainfall, and low soil fertility. In these fragile ecosystems, where microorganisms are integral to maintain functioning and primary productivity, endoliths (i.e., rock‐inhabiting microorganisms) play a key role in soil formation and dynamics and are and critical drivers of ecological succession. Here, we posit that endolithic microbes could also function as early alarm warning indicators for environmental changes in the most arid ecosystems. Nevertheless, studies on endoliths are still rather fragmentary and mainly focused in a few specific dry areas such as the Antarctic or Atacama deserts. A global appraisal of the structure and function of the endolithic microbiome is needed for the assessment of the current state of dryland biodiversity worldwide, and to identify the regions that are more vulnerable to global changes. Such an effort will provide new knowledge and will implement official and international initiatives to track and conserve biodiversity on global drylands.