bluuebunny/crossref_metadata_2025_split huggingface dataset:
Expression of NKX 3.1 in Sertoli Cell Tumors
Authors: Fatima Arooj , Mushtaq Sajid , Loya Asif 
Published: February 2023

Objective: To evaluate the NKX3.1 expression by immunohistochemistry in normal testicular parenchyma and in Sertoli cell tumours and Sertoli Leydig cell tumours of the testes and ovary.
Study Design: Retrospective longitudinal study.
Place and Duration of Study: Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore Pakistan, from 2010-2021.
Methodology: We used immunohistochemistry to evaluate the positivity and loss of nuclear expression of NKX3.1 in the Sertoli cell tumour (11 cases), Sertoli Leydig cell tumour (31 cases) and in normal testicular parenchyma (7 cases).
Results: In our study, there were 49 cases. All the cases of benign testicular parenchyma expressed positivity with nuclear staining of NKX 3.1 in Sertoli cells. Two out of 11 Sertoli cell tumours expressed positivity with nuclear positivity of NKX 3.1 in Sertoli cell component (18.18%) and 9 of the cases showed loss of staining of NKX 3.1 (81.8%). All Sertoli Leydig cell tumours showed loss of staining of NKX 3.1.
Conclusion: Nuclear expression of NKX 3.1 is seen in Sertoli cells of normal testicular parenchyma. This staining is lost in Sertoli cell tumours and Sertoli Leydig cell tumours.
Comparison of Effects of Salbutamol Inhalation with Continuous Positive Airway Pressure and Bubble Continuous Positive Airway Pressure Alone in the Management of Severe Transient Tachypnea of the Newborn
Authors: Afzal Warda , Zaidi Syed Taqi Hasan , Saba Ameena , Shujaat Wasif , Fatima Benish , Maqsood Almas 
Published: February 2023

Objective: To find the frequency of known risk factors in cases of severe transient tachypnea of the newborn (TTN) and to measure the effect of inhaled Salbutamol to bubble CPAP on required treatment duration.
Study Design: Quasi-experimental study.
Place and Duration of Study: Neonatal Intensive Care Unit, Combined Military Hospital, Malir Cantt, Karachi Pakistan, from Nov 2019 to Jun 2020.
Methodology: A total of 60 cases of severe TTN, labelled on a predefined criterion were included in the study. The sample was randomized into two groups using an alternate sampling technique. Group-A was treated with bubble CPAP alone, while in Group-B, inhaled Salbutamol was added. The response was measured regarding the time taken to settle respiratory distress.
Results: Out of 60 cases, 54(90.0%) were delivered through Caesarean section. A total of 9(15.0%) cases were born prematurely. Polycythemia was found in 10(16.6%) cases. Maternal asthma and gestational diabetes frequency were 8(13.33%) and 12(20.0%), respectively. A significant reduction was seen in the duration of respiratory distress in the study population receiving bubble CPAP with inhaled Salbutamol in the first 24 hours of illness (p-value<0.001).
Conclusion: Caesarean section is the most significant risk factor for developing TTN. Adding Salbutamol nebulization to bubble CPAP resulted in an earlier settlement of respiratory distress.
Efficacy of Autologous Serum with Antihistamine Therapy in the Treatment of Chronic Urticaria
Authors: Naz Syeda Sibgha , Mushtaq Shegref , Akhtar Aisha , Ahmed Najia 
Published: February 2023

Objective: To compare the efficacy of autologous serum with Antihistamine therapy in treating chronic urticaria.
Study Design: Quasi-experimental study.
Place and Duration of Study: Dermatology Department, Pak Emirate Military Hospital, Rawalpindi Pakistan, from Jul 2018 to Jan 2019.
Methodology: One hundred four patients of chronic urticaria (≥3 times/ week for ≥6 weeks) with ages ranging from 16 to 70 years were assigned the treatment groups using a lottery method. i.e., Group-A (autologous serum therapy) and Group-B(Antihistamine therapy). During the eight weeks of therapy, weekly Urticaria Activity Scoring (UAS-7) was utilized to quantify response in terms of the number of weals and pruritus.
Results: Of 104 patients, 75(72.12%) were females, and 29(27.88%) were males. Sixty-nine patients were between 18 to 35 years of age, with a mean age of 37.79±10.15 years in Group-A and 38.04±10.98 years in Group-B. Efficacy of Group-A (autologous serum therapy) was seen in 40(76.92%) patients while in Group-B (Antihistamine therapy) it was seen in 25(48.08%) patients(p-value =0.002).
Conclusion: Autologous serum therapy is more effective than Antihistamine therapy in treating chronic urticaria.
The Impact of Knowledge, Perception on the Major Amputation in People with Diabetic Foot Ulcers
Authors: Arif Anum , Malik Nayab Munir , Bhatti Ahsin Manzoor , Sohail Aima , Riaz Bismah , Imtiaz Mohammad Salman 
Published: February 2023

Objective: to evaluate the knowledge and practice of diabetic patients in terms of the diabetic foot and correlate it with the severity of diabetic foot and limb loss.
Study Design: Cross-sectional study
Place and Duration of Study: Department of Vascular Surgery, Combined military hospital, Lahore Pakistan, from Jan 2020 to Jan 2021.
Methodology: Data was recorded in terms of demographics, knowledge and practice of control of blood sugars and foot care of the patients. SINDBAD scoring was used to assess the severity of diabetic foot and compare it with their knowledge and practice and ultimately as an outcome of their limb salvage.
Results: Most patients 171(88.6%) already had a diabetic foot ulcer. Hypertension alone 72(37.3%) was the most common comorbid condition. A large percentage of patients, 108(63%), ultimately ended up with a limb amputation. A higher age and longer duration of diabetes were associated with an adverse outcome of diabetic foot disease. According to the SINDBAD scoring, the assessment of the foot showed the majority 142(73.6%), had lost protective sensation, with the ulcer being greater than 1cm2 in a large number 147(76.2%) of feet.
Conclusion: While steps are made for patient awareness related to diabetes and its complications, there is a need to address the decreased applicability of this knowledge by the patients, especially with regard to diabetic foot disease.
The Comparison of the Efficacy of Probiotic (Bacillus Clausii)with Yoghurt in the Management of Acute Watery Diarrhoea
Authors: Rehman Romisa , Ahmad Asad Maqbool , Razzaq Asma , Ullah Hakeem , Rehman Zarlish , Rehman Roshaan 
Published: February 2023

Objective: To compare the efficacy of Probiotics with the yoghurt in the management of children with acute diarrhoea in terms of frequency and consistency of stools.
Study Design: Quasi-experimental study.
Place and Duration of Study: Department of Paediatric Medicine, Combined Military Hospital, Peshawar Pakistan, from Jun to Dec 2020.
Methodology: Patients were allotted into three Groups A, B, or C. Group-A received a Probiotic (Bacillus Clausii), Group-B received plain yoghurt, and Group-C did not receive yoghurt or Probiotic. The outcome was an improvement in stool consistency at 72 hours. Stool consistency was assessed via Bristol stool chart along with frequency. Data were collected 72 hours after initiation of treatment.
Result: The total number of patients enrolled was 159(53 in each Group). Among these, 85(53.5%) were males, and 74(46.5%) were females. There was a statistically significant association in terms of consistency (p=0.001) and term of frequency (p<0.001) in the Probiotic and Yoghurt-Group.
Conclusion: The outcome in terms of consistency is almost equal in the Probiotic and Yoghurt-Group. However, Probiotic is superior to yoghurt in terms of frequency.
Management Outcome of Patients with Infected Sternotomy Wounds
Authors: Shabbir Farwa , Sarwar Saad ur Rehman , Rashid Mamoon , Rashid Haroon Ur , Gohar Maimoona , Khan Sohrab 
Published: February 2023

Objective: to evaluate management outcomes of post-sternotomy wounds.
Study Design: Retrospective longitudinal study.
Place and Duration of Study: Department of Plastic Surgery, Shifa International Hospital, Islamabad Pakistan, from Jan 2020 to Dec 2021.
Methodology: We reviewed 35 patients who had developed sternal wound infections post-cardiothoracic surgery. Outcomes of the study were measured using the SF-36 Quality of Life questionnaire.
Results: Our patients presented with either Pairolero Type-II 11(31.4%) or Type-III 19(54.2%) sternal wound infection. Preoperatively patients scored 296.667±69.40 in physical functional, 100.00±30.51 in limitations due to physical health, 16.67±37.90 in role limitation due to emotional problems, energy/fatigue scored 43.53±23.70, emotional well-being 163.33±23.54, social functioning as 11.40±11.66, pain score 31.25±19.90 and general health 131.67±35.31. The improvement in scores was noted in all domains postoperatively. Physical functioning mean scored as 790.00±48.07, role limitations due to physical health scored as310.34±67.32, role limitations due to emotional problems scored as 266.67±47.94, energy/fatigue 284.67±18.71, emotional well being 448.67±18.71, social functioning 185.83±12.60, pain score 164.17±22.01 and general health 316.67±34.95. Thirty-four (97.1%) out of 35 patients recovered well postoperative, with a maximum follow-up of 4 years and a minimum follow-up of 1 year. One patient expired on the sixth day of muscle flap coverage of the wound due to cardiac arrest.
Conclusion: A positive prognosis can be obtained by this treatment protocol.
Outcome of Early and Late Induction of Labour in Premature Rupture of Membranes
Authors: Sohail Amina , . Mahum , Muzaffar Tabassum , Saleem Uzma , Tahir Ali Mujtaba , Zulqarnain Hafiz 
Published: February 2023

Objective: To determine the frequency of early and late labour induction in premature rupture of membranes and compare their outcome.
Study Design: Cross sectional study.
Place and Duration of Study: Department of Obstetrics & Gynaecology, Combined Military Hospital, Rawalpindi Pakistan,from Jan-Dec 2021.
Methodology: One hundred and sixty-four pregnant women aged 18-35 years, with uncomplicated pregnancies at gestational age ≥37 weeks to ≤40 weeks with premature rupture of membranes, were included. All primigravida and multiparous with previous normal vaginal deliveries were selected. Patients were selected with reactive CTG, adequate pelvis, clear liquor and vertex presentation. Induction of labour achieved with cervical Prostaglandin E2. Labour was monitored accordingly.
Results: Seventy-four women (45%) presented (and got induction of labour) within 12 hours of premature rupture of membranes (early induction of labour), while 90(55%) fell under late induction of labour. 35(21%) were delivered by instrumental vaginal delivery, while 31(19%) were delivered by caesarian section. The most common indication of the caesarian section was fetal distress (36%), followed by poor progress of labour (32%). Patients with early induction of labour witnessed less chorioamnionitis (7% vs 18%) and post-partum haemorrhage (8% vs 13%). Likewise, with early induction of labour incidence of neonatal sepsis was less (3% vs 10%) with limited poor APGARs at birth (3% vs 12%). No early neonatal death was observed in 164 cases.
Conclusion: For women with term premature rupture of membranes, earlier induction of labour results in lower maternal and fetal morbidity.
The Outcome of Obesity in Pregnancy: A Cross-Sectional Study
Authors: Muzaffar Tabassum , Abbas Sana , Sheraz Shahida , Bano Islam , Sohail Amina , Wasim Zahra 
Published: February 2023

Objective: To find out fetal and maternal outcomes among obese pregnant females.
Study Design: Cross-sectional study.
Place and Duration of Study: Department of Gynaecology and Obstetrics, Combined Military Hospital Rawalpindi, from Jun 2020 to Jun 2021.
Methodology: A total of 124 pregnant obese women (BMI more than 30kg/m2), gestational age between 13-24 months, having fasting blood glucose and blood pressure within normal limits were enrolled in the study and were subsequently followed throughout pregnancy upon antenatal visits scheduled as per guidelines. Participants with diabetes mellitus or hypertension,above 40 years of age, family or previous history of gestational diabetes, and pre-eclampsia were also excluded from the study. Fetal and maternal outcomes were noted.
Results: One hundred and twenty-four (124) pregnant obese women were enrolled in the study with a mean age of 33.7±4.1 years (21 -38 years). Out of which, 86(69.4%) had cesarean section primarily due to pre-eclampsia, prolonged or dysfunctional labour causing fetal distress. There were 8 cases of miscarriage and 3 cases of stillbirth. 26(21.0%) women presented with gestational diabetes mellitus, 31(25.0%) with pre-eclampsia and 12(9.7%) developed both conditions. There were 7(5.6%) participants who delivered babies with macrosomia, 1(0.8%) anencephaly, 3(2.4%) congenital deafness and 1(0.8%) cleft lip.
Conclusion: Obesity in pregnancy can lead to serious maternal and fetal outcomes ranging from abortions to neonatal anomalies and fetal death. A high index of suspicion is required to diagnose and manage these difficult conditions.
Haemodialysis Alters the Index of Cardiac-Electrophysiological Balance
Authors: Arshad Abdul Rehman , Khan Tayyaba , Siddiqi Fuad Ahmad , Tahir Shabana , Ahmad Shahid , Qayyum Mohsin 
Published: February 2023

Objective: To study electrocardiographic changes during haemodialysis and determine the relationship between electrolyte alterations and acid-base balance.Study Design: Cross-sectional analytical study.
Place and Duration of Study: Haemodialysis Unit, Combined Military Hospital, Peshawar Pakistan, from Jun to Jul 2022.
Methodology: Adult patients with end-stage renal disease on maintenance hemodialysis were selected by convenience sampling. Exclusion criteria included current hospitalization, chest pain during haemodialysis, intra-dialytic hypotension,atrial fibrillation, pericardial effusion, shortening of haemodialysis sessions and unwillingness to participate in the study.Twelve lead electrocardiograms were recorded immediately before the start and end of haemodialysis sessions. At the same time, serum urea, creatinine, potassium, calcium and phosphate were measured. Bicarbonate levels were assessed by venous blood gas analysis. In addition, measurements for heart rate and durations of the PR interval, QRS complex, QT interval andcorrected QT interval reported by ECG machine software were recorded.
Results: There were 35 patients with a mean age of 48.69±11.39 years. Duration of QRS complex increased from 92.83±9.98 to 100.00± 17.94 seconds after haemodialysis (p=0.017). Changes in other parameters were insignificant. QT/QRS and QTc/QRS ratios reduced by 0.27±0.62 and 0.31±0.62 after haemodialysis (p=0.014 and 0.005, respectively). Changes in none of the biochemical parameters during haemodialysis could predict the reduction in QT/QRS or QTc/QRS ratios.
Conclusion: The reduction in the index of cardiac electrophysiological balance during hemodialysis was not related to intradialytic changes in different electrolytes or base content.
PENGARUH PEMBELAJARAN DARING TERHADAP MINAT BELAJAR SISWA DI SMP KELAS VII YP-PGRI 4 MAKASSAR
Authors: Bahar Irnayanti , Astuti Wiwik Wiji , Manggiri Manggiri 
Published: February 2023

Pembelajaran daring merupakan upaya yang dilakukan oleh pemerintah dalam rangka memenuhi kebutuhan pendidikan di era globalisasi saat ini agar tetap terlaksana secara efektif dan efisien. Tujuan dalam penelitian ini adalah untuk mengetahui Pengaruh Pembelajaran Daring Terhadap Minat Belajar Siswa di SMP kelas VII YP-PGRI 4 Makassar. Minat belajar adalah salah satu faktor yang sangat penting untuk keberhasilan belajar yang dimiliki siswa. Jumlah populasi penelitian ini adalah 20 orang siswa mengingat populasi yang ada dalam penelitian ini tergolong sedikit, maka tidak dilakukan penarikan sampel dan penelitian ini merupakan penelitian populasi. Teknik pengumpulan data yang digunakan dalam penelitian ini adalah observasi, wawancara, angket dan dokumentasi. Berdasarkan hasil penelitian dengan menggunakan pembelajaran daring menunjukkan bahwa nilai F hitung sebesar 76.357 dengan tingkat signifikansi sebesar 0.000 < 𝛼 (0.05). Hasil tersebut menunjukkan bahwa pembelajaran daring berpengaruh terhadap Minat Belajar siswa di SMP Kelas VII YP-PGRI 4 Makassar.Kata Kunci : Pembelajaran Daring, PGRI 4 Makassar
Perjanjian Pengikatan Jual Beli Hak Atas Tanah Berdasarkan Akta Notaris
Authors: Amin Mochamad , Anindito Teguh , Wiyono Wiwin Mochtar 
Published: February 2023

Abstract The purpose of this study was to determine the strength of the sale and purchase agreement deed of land rights made by a Notary in the implementation of the deed of sale and purchase of land. To achieve these objectives the author uses a normative juridical approach, Research Specifications are legal in nature. The method of presenting date is presented in the form of descriptions which are grouped and then arranged systematically. Conclusion: based on the results of the research and discussion shows that the legal strenght of the sale and purchase rights agreement on land rights made by a Notary in the implementation of the Sale Deed is very strong, because the deed is anotary deed which is an authentic deed, authorization that cannot being withdrawn in the sale and purchase agreement is not included in the absolute power that is prohibited by the Minister of Home Affairsâ€™ Instruction No. 14 of 1982 concerning Prohibition of the Use of Absolute Authorities as the Transfer of Right to Land, so that legal status is valid. Keywords:Â Agreement, Binding of Buy and Sell, Land RightsÂ AbstrakTujuan penelitian ini ialah untuk mengetahui kekuatan akta perjanjian pengikatan jual beli hak atas tanah yang dibuat oleh Notaris dalam pelaksanaan pembuatan akta jual beli tanahnya. Untuk mencapai tujuan tersebut penulis menggunakan metode pendekatan secara Yuridis Normatif, Spesifikasi Penelitian adalah bersifat penerapan hukum. Metode penyajian data disajikan dalam bentuk uraian-uraian yang dikelompokkan dan kemudian disusun secara sistematis. Kesimpulan: berdasarkan hasil penelitian dan pembahasan menunjukan bahwa kekuatan hukum dari akta perjanjian pengikatan jual beli hak atas tanah yang dibuat oleh Notaris dalam pelaksanaan pembuatan Akta Jual Belinya adalah sangat kuat, karena akta tersebut merupakan akta notaril yang bersifat akta otentik, pemberian kuasa yang tidak dapat ditarik kembali dalam perjanjian pengikatan jual beli bukanlah termasuk ke dalam kuasa mutlak yang dilarang oleh Intruksi Menteri Dalam Negeri Nomor 14 Tahun 1982 tentang Larangan Penggunaan Kuasa Mutlak Sebagai Pemindahan Hak Atas Tanah, sehingga status hukumnya sah.Kata Kunci:Â Perjanjian, Pengikatan Jual Beli, Hak Atas Tanah
Penguatan Ketaatan Hukum Sebagai Wujud Pembangunan Budaya Hukum (Pengabdian Di Desa Tuik Kecamatan Kelapa Kabupaten Bangka Barat Propinsi Kepulauan Bangka Belitung)
Authors: Anwar Reski 
Published: February 2023

Abstract Obedience to law is one of the harmony of legal culture in community life. Legal culture can be built starting from the family environment and individuals belonging to the family. The purpose of community service activities in the village of Tuik Kelapa district of West Bangka District is in order to build Community legal awareness. This dedication activities include legal counseling in arranging the technical guidelines of regulations in the village, subsequent dialogue on the Justice of women and children and the assistance of legal problems to materialize a peaceful legal culture and Orderly. The impact of this dedication activity is to develop a level of legal awareness for citizens, individuals and order and to be regulated in the Association of society. Furthermore, the results of this dedication are scientific publications, growing the level of public awareness and the formation of high concern in women and children, and understand the legal characteristics of the village regulations.Keywords: Obedience, legal culture, Tuik village.Â AbstrakKetaatan pada hukum merupakan salah satu dari terciptanya keharmonisan budaya hukum dalam kehidupanÂ bermasyarakat. Budaya hukum dapat terbina dimulai dari lingkungan keluarga dan individu-individu yang tergabung dalam keluarga. Tujuan dari kegiatan pengabdian masyarakat di Desa Tuik Kecamatan Kelapa Kabupaten Bangka Barat adalah dalam rangka membangun kesadaran hukum masyarakat. Kegiatan pengabdian ini meliputi kegiatan penyuluhan hukum dalam menyusun pedoman teknis peraturan di desa, selanjutnya dialog mengenai keadilan perempuan dan anak serta pendampingan permasalahan hukum masyarakat agar terwujud budaya hukum yang damai dan tertib. Dampak kegiatan pengabdian ini agar menumbuh kembangkan tingkat kesadaran hukum bagi warga, individu dan tercipta ketertiban serta ke teraturan dalam pergaulan masyarakat. Selanjutnya Hasil dari kegiatan pengabdian ini adalah publikasi ilmiah, berkembangnya tingkat kesadaran hukum masyarakat dan terbentuknya rasa kepedulian yang tinggi pada perempuan dan anak, serta memahami karakteristik hukum yang ada pada peraturan desa.Kata Kunci : Ketaatan, Budaya Hukum, Desa Tuik.
Unique benthic foraminiferal communities (stained) in diverse environments of sub-Antarctic fjords, South Georgia
Authors: Majewski Wojciech , Szczuciński Witold , Gooday Andrew J. 
Published: February 2023

Abstract. Sub-Antarctic fjords are among the environments most affected by the recent climate change. In our dynamically changing world, it is essential to monitor changes in these vulnerable settings. Here, we present a baseline study of “living” (rose-bengal-stained) benthic foraminifera from fjords of South Georgia, including fjords with and without tidewater glaciers. Their distribution is analyzed in the light of new fjord water and sediment property data, including grain size and sorting, total organic carbon, total sulfur, and δ13C of bulk organic matter. Four well-defined foraminiferal assemblages are recognized. Miliammina earlandi dominates in the most restricted, near-shore and glacier-proximal habitats, Cassidulinoides aff. parkerianus in mid-fjord areas, and Globocassidulina aff. rossensis and an assemblage dominated by Ammobaculites rostratus, Reophax subfusiformis, and Astrononion echolsi are in the outer parts of the fjords. Miliammina earlandi can tolerate strong glacial influence, including high sedimentation rates in fjord heads and sediment anoxia, as inferred from sediment color and total organic carbon / sulfur ratios. This versatile species thrives both in the food-poor inner reaches of fjords that receive mainly refractory petrogenic organic matter from glacial meltwater and in shallow-water coves, where it benefits from an abundant supply of fresh, terrestrial, and marine organic matter. A smooth-walled variant of C. aff. parkerianus, apparently endemic to South Georgia, is the calcareous rotaliid best adapted to inner-fjord conditions characterized by moderate glacial influence and sedimentation rates and showing no preference for particular sedimentary redox conditions. The outer parts of fjords with clear, well-oxygenated bottom water are inhabited by G. aff. rossensis. Ammobaculites rostratus, R. subfusiformis, and A. echolsi dominate in the deepest-water settings, with water salinities ≥ 33.9 PSU and temperatures 0.2–1.4 ∘C, characteristic of winter water and Upper Circumpolar Deep Water. The inner- and mid-fjord foraminiferal assemblages seem specific to South Georgia, although with continued warming and deglaciation, they may become more widespread in the Southern Ocean.