bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adding a polyphenol-rich fiber bundle to food impacts the gastrointestinal microbiome and metabolome in dogs
Authors: Fritsch Dale A. , Jackson Matthew I. , Wernimont Susan M. , Feld Geoffrey K. , Badri Dayakar V. , Brejda John J. , Cochrane Chun-Yen , Gross Kathy L. 
Published: January 2023

IntroductionPet foods fortified with fermentable fibers are often indicated for dogs with gastrointestinal conditions to improve gut health through the production of beneficial post-biotics by the pet's microbiome.MethodsTo evaluate the therapeutic underpinnings of pre-biotic fiber enrichment, we compared the fecal microbiome, the fecal metabolome, and the serum metabolome of 39 adult dogs with well-managed chronic gastroenteritis/enteritis (CGE) and healthy matched controls. The foods tested included a test food (TF1) containing a novel pre-biotic fiber bundle, a control food (CF) lacking the fiber bundle, and a commercially available therapeutic food (TF2) indicated for managing fiber-responsive conditions. In this crossover study, all dogs consumed CF for a 4-week wash-in period, were randomized to either TF1 or TF2 and fed for 4 weeks, were fed CF for a 4-week washout period, and then received the other test food for 4 weeks.ResultsMeaningful differences were not observed between the healthy and CGE dogs in response to the pre-biotic fiber bundle relative to CF. Both TF1 and TF2 improved stool scores compared to CF. TF1-fed dogs showed reduced body weight and fecal ash content compared to either CF or TF2, while stools of TF2-fed dogs showed higher pH and lower moisture content vs. TF1. TF1 consumption also resulted in unique fecal and systemic metabolic signatures compared to CF and TF2. TF1-fed dogs showed suppressed signals of fecal bacterial putrefactive metabolism compared to either CF or TF2 and increased saccharolytic signatures compared to TF2. A functional analysis of fecal tryptophan metabolism indicated reductions in fecal kynurenine and indole pathway metabolites with TF1. Among the three foods, TF1 uniquely increased fecal polyphenols and the resulting post-biotics. Compared to CF, consumption of TF1 largely reduced fecal levels of endocannabinoid-like metabolites and sphingolipids while increasing both fecal and circulating polyunsaturated fatty acid profiles, suggesting that TF1 may have modulated gastrointestinal inflammation and motility. Stools of TF1-fed dogs showed reductions in phospholipid profiles, suggesting fiber-dependent changes to colonic mucosal structure.DiscussionThese findings indicate that the use of a specific pre-biotic fiber bundle may be beneficial in healthy dogs and in dogs with CGE.
Case report: Large-size intramuscular nodular fasciitis, a challenging histopathologic diagnosis confirmed by molecular detection of USP6 gene rearrangement: Case report and literature review
Authors: Wang Changrong , Wang Wei , Xu Rujun , Xiang Jingjing 
Published: January 2023

The intramuscular subtype of nodular fasciitis (NF) is rare with lesions normally not more than 2 cm in size and characterized by pseudosarcomatous morphology. We report a case of a 27-year-old man with a large-size intramuscular NF. The patient came for treatment complaining of an increasingly enlarged mass in the left upper arm for 4 months. Magnetic resonance imaging (MRI) confirmed the presence of a well-defined tumor measuring 5 cm within the outer edge of the middle humerus. Microscopically, the neoplasm was rich in fibroblasts and myofibroblasts in an interlaced pattern with high mitotic index and evident multinuclear giant cells. Erythrocyte extravasation was easily seen in the stroma. The tumor border was infiltrative. Immunohistochemically, the tumor cells were positive for smooth muscle actin (SMA) and negative for cytokeratin, desmin, H-Caldesmon, CD34, S100, ALK, and β-catenin. Fibrosarcoma was highly suspected by histopathological and immunohistochemical examination. Molecular detection demonstrated evidence of ubiquitin-specific peptidase 6 (USP6) gene rearrangement in this tumor. Based on the findings, the tumor was diagnosed as intramuscular NF. At 56 months after the initial surgery, the patient had recovered with no evidence of recurrence or metastasis. Large-size intramuscular NF is very rare and easily overdiagnosed as malignant tumor due to its obvious pseudosarcomatoid pathological features. USP6 gene rearrangement detection can effectively avoid this major misdiagnosis.
Ipsilateral Aorto-Iliac Calcification is Not Directly Associated With eGFR After Kidney Transplantation: A Prospective Cohort Study Analyzed Using a Linear Mixed Model
Authors: Rijkse Elsaline , Roodnat Joke I. , Baart Sara J. , Bijdevaate Diederik C. , Dijkshoorn Marcel L. , Kimenai Hendrikus J. A. N. , van de Wetering Jacqueline , IJzermans Jan N. M. , Minnee Robert C. 
Published: January 2023

Aorto-iliac calcification (AIC) is a well-studied risk factor for post-transplant cardiovascular events and mortality. Its effect on graft function remains unknown. The primary aim of this prospective cohort study was to assess the association between AIC and estimated glomerular filtration rate (eGFR) in the first year post-transplant. Eligibility criteria were: ≥50 years of age or ≥30 years with at least one risk factor for vascular disease. A non-contrast-enhanced CT-scan was performed with quantification of AIC using the modified Agatston score. The association between AIC and eGFR was investigated with a linear mixed model adjusted for predefined variables. One-hundred-and-forty patients were included with a median of 31 (interquartile range 26–39) eGFR measurements per patient. No direct association between AIC and eGFR was found. We observed a significant interaction between follow-up time and ipsilateral AIC, indicating that patients with higher AIC scores had lower eGFR trajectory over time starting 100 days after transplant (p = 0.014). To conclude, severe AIC is not directly associated with lower post-transplant eGFR. The significant interaction indicates that patients with more severe AIC have a lower eGFR trajectory after 100 days in the first year post-transplant.
Quelques pistes pour une étude diachronique des titres en français : monsieur, monseigneur, milord
Authors: Lagorgette Dominique 
Published: January 2023

Dominique Lagorgette : Elements for the diachronic study of French honorifics : monsieur, monseigneur, milord.
This article focuses on the diachronic study ofthe French series of honorifics composed by the possessive adjective and a title (as in monseigneur). It first questions the morphological regularity ofthe whole series (comparing the masculine forms with the feminine nouns madame and mademoiselle) and their syntactical properties, in particular regarding the adjunction of articles (le monsieur I *la madame). It then concentrates on the masculine series (monsieur, monseigneur and milord) in order to underline how enunciative and pragmatic parameters seem to have govemed its development during the middle ages : our hypothsesis is that the early possibility for those titles of respect (with the article) to show axiological judgements is linked to their use within the curial style and the anaphorical article ledit.
Mechanical Thrombectomy in Ischemic Stroke: Current State of the Problem. Literature Review
Authors: С.Д. Кулеш, , Л.Ф. Васильчук, , П.Г. Хоперский, , А.С. Мальевская, 
Published: January 2023

Механическая тромбэктомия является эффективным методом лечения ишемического инсульта. Многочисленные исследования, проведенные за последние годы, подтвердили ее безопасность и эффективность при лечении пациентов с окклюзией крупных сосудов переднего отдела кровообращения в течение 24 часов от начала инсульта. В 2015 году несколько крупных исследований (MR CLEAN, ESCAPE, SWIFT PRIME, REVASCAT и EXTEND IA) установили превосходство механической эндоваскулярной тромбэктомии над медикаментозным лечением инсультов. В этих испытаниях пациентов отбирали на основании локализации окклюзии (проксимальная передняя окклюзия: внутренняя сонная или средняя мозговая артерия), времени от начала инсульта (раннее окно до 6 часов) и приемлемой тяжести инфаркта (совокупный балл по шкале инсультной программы Альберты (ASPECTS) ≥6 или объем инфаркта <50 мл). Последующие испытания DAWN и DEFUSE 3 успешно расширили временное окно до 24 часов у надлежащим образом отобранных пациентов. Эти данные учтены в международных и национальных рекомендациях по ведению инсульта.
Mechanical thrombectomy is an effective treatment for ischemic stroke. Numerous studies conducted in recent years have confirmed its safety and efficacy in the treatment of patients with occlusion of large vessels of the anterior circulation within 24 hours from the onset of a stroke. In 2015, several large studies (MR CLEAN, ESCAPE, SWIFT PRIME, REVASCAT and EXTEND IA) established the superiority of mechanical endovascular thrombectomy over medical treatment of stroke. In these trials, patients were selected based on the location of the occlusion (proximal anterior occlusion: internal carotid or middle cerebral artery), time from onset of stroke (early window up to 6 hours), and acceptable infarct severity (Alberta Stroke Program (ASPECTS) cumulative score ≥6 or infarct volume <50 ml). Subsequent trials of DAWN and DEFUSE 3 successfully extended the time window to 24 hours in appropriately selected patients. These data are taken into account in international and national guidelines for the management of stroke.
Modern View on the Problem of Diagnosis and Treatment of Vestibular Migraine
Authors: И.П. Марьенко, 
Published: January 2023

Головокружение и головная боль являются одними из самых распространенных жалоб в практике врачей различных специальностей. МКГБ-3, 2018 г., выделяет А1.6.6 Вестибулярную мигрень и эпизодические синдромы, которые могут быть связаны с мигренью. Патофизиология головокружения представлена дисфункцией вестибулярной и слуховой коры, вовлечением в процесс распространяющейся корковой депрессии вестибулярных ядер, тригеминальной системы и таламокортикальных путей, структур внутреннего уха.Представлен дифференциальный диагноз вестибулярной мигрени с заболеваниями внутреннего уха. Купируют вестибулярную мигрень противомигренозными средствами и вестибулярными супрессантами. Профилактическая терапия включает антидепрессанты и антиконвульсанты, вестибулярную реабилитацию и психотерапию.
Vertigo and headache are the most common complaints in the doctors practice of various specialties. ICHA-3, 2018 identifies 1.6.6 vestibular migraine and episodic syndromes that may be associated with migraine. The pathophysiology of vertigo is represented by dysfunction of the vestibular and auditory cortex, involvement in the process of spreading cortical depression of the vestibular nuclei, trigeminal system and thalamocortical pathways, structures of the inner ear. The differential diagnosis of vestibular migraine with diseases of the inner ear is presented. Vestibular migraine is stopped with antimigrainous agents and vestibular suppressants. Preventive therapy includes antidepressants and anticonvulsants, vestibular rehabilitation and psychotherapy.
Therapeutic and Diagnostic Sequence Using Acupressure and APP Therapy for the Relief of Myofascial Facial Pain. Case Report
Authors: С.А. Лихачев, , С.А. Миронов, 
Published: January 2023

Миофасциальный болевой синдром (МФБС) – один из самых частых видов соматогенной боли. Опираясь на анамнез, жалобы и неврологический осмотр, зачастую сложно дифференцировать данный вид боли и схожую боль, которая сопровождает другие заболевания. Основной отличительной чертой МФБС является наличие триггерных точек, раздражая которые мы вызываем воспроизведение знакомой пациенту боли. МФБС возникает не только в крупных мышцах человека, таких как мышцы туловища, верхних и нижних конечностей, но и в небольших мышцах, таких как мышцы лица, кистей, стоп и др. Формирование триггерных точек в мышцах лица приводит к возникновению выраженных головных и лицевых болей, которые не реагируют на классические методы лечения. В статье авторы представили клинический случай миофасциальной лицевой боли, результаты лечения и наблюдения за данной пациенткой.
Myofascial pain syndrome (MFPS) is one of the most common types of somatogenic pain. Based on the anamnesis, complaints and neurological examination, it is often difficult to differentiate this type of pain from similar pain that accompanies other diseases. The main distinguishing feature of MFPS is the presence of trigger points, irritating which we cause the reproduction of pain familiar to the patient. MFPS occurs not only in large human muscles, such as the muscles of the trunk, upper and lower extremities, but also in small muscles, such as the muscles of the face, hands, feet, etc. The formation of trigger points in the muscles of the face leads to severe headaches and facial pains that do not respond to classical methods of treatment. In the article, the authors presented a clinical case of myofascial facial pain, the results of treatment and observation of this patient.
Familial Amyotrophic Lateral Sclerosis (Pathogenic Mutations in the SOD1 Gene): Own Clinical Observations
Authors: Ю.Н. Рушкевич, , Е.В. Мальгина, , А.А. Гусина, , О.В. Галиевская, , О.В. Переверзева, , Н.А. Кабирова, , Т.В. Корбут, , С.А. Лихачев, 
Published: January 2023

Мутации в гене супероксиддисмутазы 1 (SOD1) связаны с боковым амиотрофическим склерозом (БАС) – нейродегенеративным заболеванием, преимущественно поражающим верхние и нижние двигательные нейроны, характеризующимся неуклонным прогрессированием и развитием мышечных атрофий, спастичности, пирамидных знаков. На сегодняшний день описано более 180 различных мутаций гена SOD1, включая точечные мутации, делеции и инсерции по пяти экзонам гена SOD1. Большинство мутаций наследуется по аутосомно-доминантному типу. Семейный БАС выявляется у каждого 10-го пациента, то есть в 10% случаев. Мутация в гене SOD1 ассоциирована с более ранним (до 40 лет) дебютом БАС, а также с его более быстрой и агрессивной прогрессией, приводя в конечном итоге к гибели пациентов, чаще от дыхательной недостаточности. Медико-генетическое исследование БАС имеет большое значение для понимания сложных патогенетических механизмов, ведущих к дегенерации двигательных нейронов. В настоящем исследовании мы представляем описание собственных клинических генетически подтвержденных случаев бокового амиотрофического склероза с гетерозиготной мутацией в гене SOD1 для демонстрации особенностей клинической картины и наследственного анамнеза наших пациентов.
Mutations in the superoxide dismutase 1 (SOD1) gene are associated with amyotrophic lateral sclerosis, a neurodegenerative disease predominantly affecting upper and lower motor neurons, characterized by steady progression and development of muscle atrophy, spasticity and pyramidal signs. To date, more than 180 different mutations of the SOD1 gene have been proposed, including point mutations, deletions, and insertions in five exons of the SOD1 gene. Most mutations are inherited in an autosomal dominant manner. Familial ALS is detected in every 10 patients, that is, in 10% of cases. A mutation in the SOD1 gene is associated with an earlier (up to 40 years) onset of ALS, as well as with its more rapid and aggressive progression, leading to the development most often in observable patients, most often from respiratory failure. Medical genetic study of ALS is important for studying the complex pathogenetic mechanisms associated with motor neuron degeneration. In this study we present our own clinical descriptions of genetically confirmed cases of amyotrophic lateral sclerosis with a heterozygous mutation in the SOD1 gene to demonstrate the features of the clinical picture and hereditary history of our patients.
Efektivitas Kombinasi Ibuprofen dan Parasetamol terhadap Kualitas Analgesia Pasca Odontektomi Molar Tiga
Authors: Gazali Mohammad , Hadira Hadira , Nur Islam Ahmad , Tajrin Andi , Nilawati Nilawati 
Published: January 2023

Abstract: Third molar odontectomy is a common oral and maxillofacial surgical procedure associated with local tissue injury with varying levels of postoperative pain. Acute pain management guidelines recommend multimodal treatment because its additive or synergistic effects between drugs can enhance analgesia which can be achieved at lower doses, therefore, potentially reduce the risk of side effects. This study aimed to discuss the effectiveness of the combination of ibuprofen and paracetamol on the quality of analgesia after third molar odontectomy. This was a literature review using PubMed and Google Scholar databases for original articles, case reports, and reviews, and the keywords were post odontectomy pain, multimodal analgesia, ibuprofen, and paracetamol. The results obtained seven literatures; six of them reported that the combination of ibuprofen and paracetamol in various dosages had a better analgesia effect and a faster onset than a single dose. In conclusion, the combination of para-cetamol and ibuprofen provides much better analgesic effect and faster onset than comparable doses of single agent or placebo in adults after third molar odontectomy.
Keywords: odontectomy; pain; ibuprofen; paracetamol

Abstrak: Odontektomi molar tiga ialah tindakan bedah regio oral dan maksilofasial yang umum dilakukan dan terkait cedera jaringan lokal dengan berbagai tingkat nyeri pasca operasi. Pedoman manajemen nyeri akut merekomendasikan pengobatan multimodal karena efek aditif atau sinergis antar obat dapat meningkatkan analgesia yang efeknya dapat dicapai pada dosis lebih rendah dan berpotensi mengurangi risiko efek samping. Penelitian ini bertujuan untuk membahas efektivitas kombinasi ibuprofen dan parasetamol terhadap kualitas analgesia pasca odontektomi molar tiga. Jenis penelitian ialah suatu literature review, dan pencarian menggunakan PubMed dan Google Scholar untuk artikel asli, laporan kasus, dan ulasan dengan kata kunci nyeri pasca odontektomi, analgesia multimodal, ibuprofen, dan parasetamol. Hasil penelitian mendapatkan tujuh literatur, enam di antaranya melaporkan bahwa kombinasi ibuprofen dan parasetamol dalam berbagai varian dosis memiliki efek analgesia yang lebih baik dan onset yang lebih cepat dibanding dosis tunggal. Simpulan penelitian ini ialah kombinasi parasetamol dan ibuprofen memberikan efek analgesik yang lebih baik dan onset yang lebih cepat dibandingkan dengan dosis tunggal atau plasebo pada orang dewasa setelah odontektomi molar ketiga.
Kata kunci: odontektomi; nyeri; ibuprofen; parasetamol
The endpoint detection method using moiré pattern in CMP’s EPD system
Authors: Takitani Sho , Yamamoto Soma , Matsuo Hisanori , Watanabe Katsuhide , Suzuki Keisuke 
Published: January 2023

Abstract
We have developed a technique for observing fine wiring patterns using moiré patterns generated by interference between wiring patterns and reference patterns in endpoint detection (EPD) of the CMP. With this technique, wiring pattern images of patterned wafers can be evaluated with a simple and low magnification optical system to observe large moiré patterns. In this process, the large moiré pattern is calculated from the device wiring and other reference pattern layouts. As a result, EPD signals can be detected.
Parallel metal–insulator–metal diode with an ultrathin spin-coated hydrogen silsesquioxane insulating layer
Authors: Akahane Takashi , Ishii Sho , Yanagisawa Keisuke , Yin You 
Published: January 2023

Abstract
In this study, we investigated a parallel metal–insulator–metal (MIM) diode with an ultrathin spin-coated hydron silsesquioxane (HSQ) layer. Ti and Au were adopted as the metal electrodes for the large work function difference. Conditions to obtain the ultrathin HSQ layer with a thickness of below 5 nm for tunneling were predicted and Ti/HSQ/Au diode devices with a parallel electrode arrangement were fabricated by using the conditions. The typical current–voltage characteristics of the fabricated diodes exhibited asymmetry of about 1.8 at 3.0 V. It was demonstrated that the dynamic zero bias resistance of the diodes was as low as about 8 MΩ. Based on the Simmons model, the estimated oxide-equivalent thickness of HSQ in the device was about 1.7 nm, which was in good agreement with the prediction. The good figures of merit of the fabricated diodes imply that the spin-coated ultrathin HSQ is very suitable for this application.
Resonance properties of shear-horizontal surface acoustic waves on Ca3TaGa3Si2O14 at room and high temperatures
Authors: Suzuki Ryoto , Suzuki Masashi , Kakio Shoji , Kimura Noritoshi 
Published: January 2023

Abstract
The resonance properties of shear-horizontal surface acoustic waves on Ca3TaGa3Si2O14 (CTGS) with Au or Al interdigital transducers (IDTs) were investigated. IDT-type resonators were fabricated on CTGS (0°, 134° or 155°, 90°) using Au- or Al-IDT, and the strong resonance properties and near-zero temperature coefficient of frequency (TCF) were measured at a certain electrode film thickness. From the measured and simulated results, an effective coupling factor of approximately 1.2% and zero TCF can be simultaneously obtained by using not only a high-density Au-IDT but also an Al-IDT and by adjusting the cut angle and electrode film thickness. Moreover, the resonance properties on Au-IDT/CTGS were evaluated at temperatures up to 570 °C. From the cut-angle dependences of the frequency shift calculated using the determined second-order temperature coefficients of the elastic constants, the potential for sensor applications that measure not only temperature but also pressure in such high-temperature environments can be expected.
Electronic structure of covalent networks of triangular graphene flakes embedded in hBN
Authors: Zhang Hui , Maruyama Mina , Gao Yanlin , Okada Susumu 
Published: January 2023

Abstract
Covalent networks of triangular graphene flakes ([n]triangulenes) embedded in hexagonal boron nitride (hBN) were theoretically investigated using density functional theory. Our calculations reveal that the electronic structure of these in-plane heterostructures comprising B, C, and N atoms strongly depends on the arrangements of the constituent triangular graphene flakes and border atom species. Heterostructures comprising a copolymer of [n]triangulene and [m]triangulene embedded in hBN are tiny gap semiconductors or metals for which flat dispersion bands emerge near and at the Fermi level. A heterostructure comprising [3]triangulene is a semiconductor with a moderate direct gap of 0.7 eV, in which the band edges exhibit a flat band nature throughout the Brillouin zone. These flat band states are attributed to the hybridization between the non-bonding states of the triangulenes and the pz orbitals of the B and N atoms at the borders.
Volume difference in microdroplets in vertical contact control under electrowetting-induced asymmetric boundary condition
Authors: Bono Shinji , Miyata Yoshinori , Konishi Satoshi 
Published: January 2023

Abstract
Three-dimensional manipulation of microdroplets is attractive for biochemical science applications. In vertical contact control, we contact a microdroplet and an opposite droplet to diffuse chemicals between microdroplets. Then, we separate coalescent droplets into two microdroplets. However, vertical contact control of opposite microdroplets results in a volume difference due to gravity. We integrate electrowetting into the wetting pattern substrates to control the volume difference. When voltage is applied to electrowetting substrates, dielectric interaction generates an attractive force in the opposite direction to gravity. We quantitatively investigated the volume difference after vertical contact control under applied voltage. Thus, we discovered that the volume difference monotonously decreases as the voltage increases. Next, our force balance theory, in which the effect of electrowetting is an asymmetric boundary condition, quantitatively correlates with experimental results.