bluuebunny/crossref_metadata_2025_split huggingface dataset:
Validation of the prognostic significance of the 2022 European LeukemiaNet risk stratification system in intensive chemotherapy treated aged 18 to 65 years patients with de novo acute myeloid leukemia
Authors: Lo Min‐Yen , Tsai Xavier Cheng‐Hong , Lin Chien‐Chin , Tien Feng‐Ming , Kuo Yuan‐Yeh , Lee Wan‐Hsuan , Peng Yen‐Ling , Liu Ming‐Chih , Tseng Mei‐Hsuan , Hsu Cheng‐An , Chen Jui‐Che , Lin Liang‐In , Sun Hsun‐I , Chuang Yi‐Kuang , Ko Bor‐Sheng , Tang Jih‐Luh , Yao Ming , Chou Wen‐Chien , Hou Hsin‐An , Tien Hwei‐Fang 
Published: March 2023

AbstractThe European LeukemiaNet (ELN) recently proposed a revised recommendation for the diagnosis and management of acute myeloid leukemia (AML) in adults, recognized as ELN‐2022. However, validation in a large real‐world cohort remains lacking. In this study, we aimed to validate the prognostic relevance of the ELN‐2022 in a cohort of 809 de novo, non‐M3, younger (ages 18–65 years) AML patients receiving standard chemotherapy. The risk categories of 106 (13.1%) patients were reclassified from that determined using ELN‐2017 to that determined using ELN‐2022. The ELN‐2022 effectively helped distinguish patients as favorable, intermediate, and adverse risk groups in terms of remission rates and survival. Among patients who achieved first complete remission (CR1), allogeneic transplantation was beneficial for those in the intermediate risk group, but not for those in the favorable or adverse risk groups. We further refined the ELN‐2022 system by re‐categorizing AML patients with t(8;21)(q22;q22.1)/RUNX1::RUNX1T1 with KIThigh, JAK2 or FLT3‐ITDhigh mutations into the intermediate risk subset, AML patients with t(7;11)(p15;p15)/NUP98::HOXA9 and AML patients with co‐mutated DNMT3A and FLT3‐ITD into the adverse risk subsets, and AML patients with complex or monosomal karyotypes, inv (3)(q21.3q26.2) or t(3;3)(q21.3;q26.2)/GATA2,MECOM(EVI1) or TP53 mutation into the very adverse risk subset. The refined ELN‐2022 system performed effectively to distinguish patients as favorable, intermediate, adverse, and very adverse risk groups. In conclusion, the ELN‐2022 helped distinguish younger, intensively treated patients into three groups with distinct outcomes; the proposed refinement of ELN‐2022 may further improve risk stratification among AML patients. Prospective validation of the new predictive model is necessary.
Dissipating the fog: Cognitive trajectories and risk factors 1 year after COVID‐19 hospitalization
Authors: Gonçalves Natalia Gomes , Aliberti Márlon Juliano Romero , Bertola Laiss , Avelino‐Silva Thiago , Dias Murilo Bacchini , Apolinario Daniel , Busatto Geraldo , Forlenza Orestes , Nitrini Ricardo , Brucki Sonia Maria Dozzi , Brunoni Andre Russowsky , Vidal Kallene Summer Moreira , Jacob‐Filho Wilson , Suemoto Claudia Kimie ,   CO‐FRAIL Study Group, for the COVID HCFMUSP Study Group
Published: March 2023

AbstractIntroductionCognitive impairment is common after severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection. However, associations between post‐hospital discharge risk factors and cognitive trajectories have not been explored.MethodsA total of 1105 adults (mean age ± SD 64.9 ± 9.9 years, 44% women, 63% White) with severe coronavirus disease 2019 (COVID‐19) were evaluated for cognitive function 1 year after hospital discharge. Scores from cognitive tests were harmonized, and clusters of cognitive impairment were defined using sequential analysis.ResultsThree groups of cognitive trajectories were observed during the follow‐up: no cognitive impairment, initial short‐term cognitive impairment, and long‐term cognitive impairment. Predictors of cognitive decline after COVID‐19 were older age (β = −0.013, 95% CI = −0.023;−0.003), female sex (β = −0.230, 95% CI = −0.413;−0.047), previous dementia diagnosis or substantial memory complaints (β = −0.606, 95% CI = −0.877;−0.335), frailty before hospitalization (β = −0.191, 95% CI = −0.264;−0.119), higher platelet count (β = −0.101, 95% CI = −0.185;−0.018), and delirium (β = −0.483, 95% CI = −0.724;−0.244). Post‐discharge predictors included hospital readmissions and frailty.DiscussionCognitive impairment was common and the patterns of cognitive trajectories depended on sociodemographic, in‐hospital, and post‐hospitalization predictors.Highlights
Cognitive impairment after coronavirus disease 2019 (COVID‐19) hospital discharge was associated with higher age, less education, delirium during hospitalization, a higher number of hospitalizations post discharge, and frailty before and after hospitalization.
Frequent cognitive evaluations for 12‐month post‐COVID‐19 hospitalization showed three possible cognitive trajectories: no cognitive impairment, initial short‐term impairment, and long‐term impairment.
This study highlights the importance of frequent cognitive testing to determine patterns of COVID‐19 cognitive impairment, given the high frequency of incident cognitive impairment 1 year after hospitalization.
Eine durchflusszytometrische Ultra‐Hochdurchsatz‐Durchmusterungsmethode für die Gelenkte Evolution von Oxidasen
Authors: Feng Lilin , Gao Liang , Besirlioglu Volkan , Essani Khalil , Wittwer Malte , Kurkina Tetiana , Ji Yu , Schwaneberg Ulrich 
Published: March 2023

AbstractOxidasen sind bedeutsam für die chemische und pharmazeutische Industrie, da sie hochselektive Oxidationen katalysieren. Allerdings müssen natürlich vorkommende Oxidasen für synthetische Anwendungen häufig mittels Gelenkter Evolution im Labor maßgeschneidert werden. Hierfür haben wir die breit anwendbare und robuste Durchmusterungs‐Plattform “FlOxi” entwickelt. FlOxi ist eine Durchflusszytometriemethode und nutzt Wasserstoffperoxid als Reaktionssnebenprodukt von in E. coli exprimierten Oxidasen, um Fe2+ zu Fe3+ zu oxidieren (Fenton‐Reaktion). Fe3+ vermittelt dabei die Immobilisierung von His6‐“markiertem” eGFP (eGFPHis) auf der E. coli‐Zelloberfläche, wodurch die Identifizierung von aktiven Oxidase‐Varianten mittels Durchflusszytometrie ermöglicht wird. FlOxi wurde mit zwei Oxidasen – einer Galaktose‐Oxidase (GalOx) und einer D‐Aminosäure‐Oxidase (D‐AAO) – validiert. Hierbei wurde in einer Gelenkten Evolutionsrunde eine GalOx‐Variante (T521A) mit einem 4.4‐fach niedrigeren Km‐Wert und eine D‐AAO‐Variante (L86M/G14/A48/T205) mit einem 4.2‐fach höheren kcat‐Wert aufgefunden. FlOxi kann universell für die Gelenkte Evolution von Wasserstoffperoxid‐produzierenden Oxidasen, auch für nicht‐fluoreszierende Substrate, eingesetzt werden.
Engineering a Self‐Grown TiO2/Ti‐MOF Heterojunction with Selectively Anchored High‐Density Pt Single‐Atomic Cocatalysts for Efficient Visible‐Light‐Driven Hydrogen Evolution
Authors: He Xiaoyu , Ding Yujia , Huang Zhennan , Liu Min , Chi Miaofang , Wu Zili , Segre Carlo U. , Song Chunshan , Wang Xiang , Guo Xinwen 
Published: March 2023

AbstractA photocatalyst TiO2/Ti‐BPDC‐Pt is developed with a self‐grown TiO2/Ti‐metal–organic framework (MOF) heterojunction, i.e., TiO2/Ti‐BPDC, and selectively anchored high‐density Pt single‐atomic cocatalysts on Ti‐BPDC for photocatalytic hydrogen evolution. This intimate heterojunction, growing from the surface pyrolytic reconstruction of Ti‐BPDC, works in a direct Z‐scheme, efficiently separating electrons and holes. Pt is selectively anchored on Ti‐BPDC by ligands and is found in the form of single atoms with loading up to 1.8 wt %. The selective location of Pt is the electron‐enriched domain of the heterojunction, which further enhances the utilization of the separated electrons. This tailored TiO2/Ti‐BPDC‐Pt shows a significantly enhanced activity of 12.4 mmol g−1 h−1 compared to other TiO2‐ or MOF‐based catalysts. The structure‐activity relationship further proves the balance of two simultaneously exposed domains of heterojunctions is critical to fulfilling this kind of catalyst.
Solid‐Adsorbed Polymer‐Electrolyte Interphases for Stabilizing Metal Anodes in Aqueous Zn and Non‐Aqueous Li Batteries
Authors: Jin Shuo , Deng Yue , Chen Pengyu , Hong Shifeng , Garcia‐Mendez Regina , Sharma Arpita , Utomo Nyalaliska W. , Shao Yiqi , Yang Rong , Archer Lynden A. 
Published: March 2023

AbstractPolymers are known to adsorb spontaneously from liquid solutions in contact with high‐energy substrates to form configurationally complex, but robust phases that often exhibit higher durability than might be expected from the individual physical bonds formed with the substrate. Rational control of the physical, chemical, and transport properties of such interphases has emerged as a fundamental opportunity for scientific and technological advances in energy storage technology but requires in‐depth understanding of the conformation states and electrochemical effect of the adsorbed polymers. Here, we analyze the interfacial adsorption of oligomeric polyethylene glycol (PEG) chains of moderate sizes dissolved in protic and aprotic liquid electrolytes and find that there is an optimum polymer molecular weight of approximately 400 Da at which the highest columbic efficiency is achieved for both Zn and Li deposition. These findings point to a simple, versatile approach for extending the lifetime of batteries.
Ir Nanoparticles Anchored on Metal‐Organic Frameworks for Efficient Overall Water Splitting under pH‐Universal Conditions
Authors: Yang Jun , Shen Yong , Sun Yamei , Xian Jiahui , Long Yanju , Li Guangqin 
Published: March 2023

AbstractThe construction of high‐activity and low‐cost electrocatalysts is critical for efficient hydrogen production by water electrolysis. Herein, we developed an advanced electrocatalyst by anchoring well‐dispersed Ir nanoparticles on nickel metal‐organic framework (MOF) Ni‐NDC (NDC: 2,6‐naphthalenedicarboxylic) nanosheets. Benefiting from the strong synergy between Ir and MOF through interfacial Ni−O−Ir bonds, the synthesized Ir@Ni‐NDC showed exceptional electrocatalytic performance for hydrogen evolution reaction (HER), oxygen evolution reaction (OER) and overall water splitting in a wide pH range, superior to commercial benchmarks and most reported electrocatalysts. Theoretical calculations revealed that the charge redistribution of Ni−O−Ir bridge induced the optimization of H2O, OH* and H* adsorption, thus leading to the accelerated electrochemical kinetics for HER and OER. This work provides a new clue to exploit bifunctional electrocatalysts for pH‐universal overall water splitting.
Heterocyclic Chromophore Amphiphiles and their Supramolecular Polymerization
Authors: Đorđević Luka , Sai Hiroaki , Yang Yang , Sather Nicholas A. , Palmer Liam C. , Stupp Samuel I. 
Published: March 2023

AbstractSupramolecular polymerization of π‐conjugated amphiphiles in water is an attractive approach to create functional nanostructures. Here, we report on the synthesis, optoelectronic and electrochemical properties, aqueous supramolecular polymerization, and conductivity of polycyclic aromatic dicarboximide amphiphiles. The chemical structure of the model perylene monoimide amphiphile was modified with heterocycles, essentially substituting one fused benzene ring with thiophene, pyridine or pyrrole rings. All the heterocycle‐containing monomers investigated underwent supramolecular polymerization in water. Large changes to the monomeric molecular dipole moments led to nanostructures with low electrical conductivity due to diminished interactions. Although the substitution of benzene with thiophene did not notably change the monomer dipole moment, it led to crystalline nanoribbons with 20‐fold higher electrical conductivity, due to enhanced dispersion interactions as a result of the presence of sulfur atoms.
A Flow Cytometry‐Based Ultrahigh‐Throughput Screening Method for Directed Evolution of Oxidases
Authors: Feng Lilin , Gao Liang , Besirlioglu Volkan , Essani Khalil , Wittwer Malte , Kurkina Tetiana , Ji Yu , Schwaneberg Ulrich 
Published: March 2023

AbstractOxidases are of interest to chemical and pharmaceutical industries because they catalyze highly selective oxidations. However, oxidases found in nature often need to be re‐engineered for synthetic applications. Herein, we developed a versatile and robust flow cytometry‐based screening platform “FlOxi” for directed oxidase evolution. FlOxi utilizes hydrogen peroxide produced by oxidases expressed in E. coli to oxidize Fe2+ to Fe3+ (Fenton reaction). Fe3+ mediates the immobilization of a His6‐tagged eGFP (eGFPHis) on the E. coli cell surface, ensuring the identification of beneficial oxidase variants by flow cytometry. FlOxi was validated with two oxidases—a galactose oxidase (GalOx) and a D‐amino acid oxidase (D‐AAO)—yielding a GalOx variant (T521A) with a 4.4‐fold lower Km value and a D‐AAO variant (L86M/G14/A48/T205) with a 4.2‐fold higher kcat than their wildtypes. Thus, FlOxi can be used for the evolution of hydrogen peroxide‐producing oxidases and applied for non‐fluorescent substrates.
Electronic Structure Manipulation of the Mott Insulator RuCl3 via Single‐Crystal to Single‐Crystal Topotactic Transformation
Authors: Lu Weiqun , Lee Hyungseok , Cha Joonil , Zhang Jian , Chung In 
Published: March 2023

AbstractThe core task for Mott insulators includes how rigid distributions of electrons evolve and how these induce exotic physical phenomena. However, it is highly challenging to chemically dope Mott insulators to tune properties. Herein, we report how to tailor electronic structures of the honeycomb Mott insulator RuCl3 employing a facile and reversible single‐crystal to single‐crystal intercalation process. The resulting product (NH4)0.5RuCl3⋅1.5 H2O forms a new hybrid superlattice of alternating RuCl3 monolayers with NH4+ and H2O molecules. Its manipulated electronic structure markedly shrinks the Mott–Hubbard gap from 1.2 to 0.7 eV. Its electrical conductivity increases by more than 103 folds. This arises from concurrently enhanced carrier concentration and mobility in contrary to the general physics rule of their inverse proportionality. We show topotactic and topochemical intercalation chemistry to control Mott insulators, escalating the prospect of discovering exotic physical phenomena.
Lewis Acid‐Mediated Radical Stabilization and Dynamic Covalent Bonding: Tunable, Reversible and Photocontrollable
Authors: Liu Min , Yang Xing , Sun Quanchun , Wang Tao , Pei Runbo , Yang Xingyu , Zhao Yue , Zhao Lili , Frenking Gernot , Wang Xinping 
Published: March 2023

AbstractThis work describes a strategy not only to isolate a dynamically stable radical with physical property tunability, but to efficiently regulate the radical dissociation with reversibility and photo controllability. The addition of Lewis acid B(C6F5)3 (BCF) into the solution of a radical σ‐dimer (1‐1) led to a stable radical (1⋅‐2B), which has been characterized by EPR spectroscopy, UV/Vis spectroscopy and single crystal X‐ray diffraction, in conjunction with theoretical calculation. The radical species is stabilized mainly by captodative effect, single electron transfer and steric effect. The absorption maximum of the radical can be tuned by using different Lewis acids. Dimer 1‐1 can be achieved back by addition of a stronger base into the solution of 1⋅‐2B, exhibiting a reversible process. By introducing a photo BCF generator, the dissociation of the dimer and the formation of the radical adduct become photocontrollable.
Phase Instability in van der Waals In2Se3 Determined by Surface Coordination
Authors: Yan Shanru , Xu Chao , Zhong Cenchen , Chen Yancong , Che Xiangli , Luo Xin , Zhu Ye 
Published: March 2023

Abstractvan der Waals In2Se3 has attracted significant attention for its room‐temperature 2D ferroelectricity/antiferroelectricity down to monolayer thickness. However, instability and potential degradation pathway in 2D In2Se3 have not yet been adequately addressed. Using a combination of experimental and theoretical approaches, we here unravel the phase instability in both α‐ and β′‐In2Se3 originating from the relatively unstable octahedral coordination. Together with the broken bonds at the edge steps, it leads to moisture‐facilitated oxidation of In2Se3 in air to form amorphous In2Se3−3xO3x layers and Se hemisphere particles. Both O2 and H2O are required for such surface oxidation, which can be further promoted by light illumination. In addition, the self‐passivation effect from the In2Se3−3xO3x layer can effectively limit such oxidation to only a few nanometer thickness. The achieved insight paves way for better understanding and optimizing 2D In2Se3 performance for device applications.
Asymmetric Synthesis of Vicinal Tetrasubstituted Diamines via Reductive Coupling of Ketimines Templated by Chiral Diborons
Authors: Zhou Mingkang , Lin Yaodong , Chen Xiao‐Xuan , Xu Guangqing , Chung Lung Wa , Tang Wenjun 
Published: March 2023

AbstractWe herein describe the chiral diboron‐templated asymmetric homocoupling of aryl alkyl ketimines, providing for the first time a series of chiral vicinal tetrasubstituted diamines with excellent ee values and good to high yields. The powerful and efficient diboron‐participated [3,3]‐sigmatropic rearrangement is successfully demonstrated by the homocoupling of a variety of ketimines thanks to the rational design and engineering of chiral diborons. Systematic DFT studies suggest that two chiral diborons adopt different conformational assembling strategies to couple the diboron template with ketimine substrates in their tight concerted transition states to ensure the excellent enantioselectivities. The synthetic value of chiral vicinal tetrasubstituted diamines is demonstrated by the asymmetric α‐bromination of aliphatic aldehydes by employing a chiral vicinal tetrasubstituted diamine‐based organocatalyst.
Unlocking a (Pseudo)‐Mechanically Interlocked Molecule with a Coronene “Shoehorn”
Authors: Ibáñez Susana , Świderek Katarzyna , Peris Eduardo 
Published: March 2023

AbstractMechanically interlocked molecules (MIMs) have gained increasing interest during the last decades, not only because of their aesthetic appeal, but also because their unique properties have allowed them to find applications in nanotechnology, catalysis, chemosensing and biomedicine. Herein we describe how a pyrene molecule with four octynyl substituents can be easily encapsulated within the cavity of a tetragold(I) rectangle‐like metallobox, by template formation of the metallo‐assembly in the presence of the guest. The resulting assembly behaves as a mechanically interlocked molecule (MIM), in which the four long limbs of the guest protrude from the entrances of the metallobox, thus locking the guest inside the cavity of the metallobox. The new assembly resembles a metallo‐suit[4]ane, given the number of protruding long limbs and the presence of the metal atoms in the host molecule. However, unlike normal MIMs, this molecule can release the tetra‐substituted pyrene guest by the addition of coronene, which can smoothly replace the guest in the cavity of the metallobox. Combined experimental and computational studies allowed the role of the coronene molecule in facilitating the release of the tetrasubstituted pyrene guest to be explained, through a process that we named “shoehorning”, as the coronene compresses the flexible limbs of the guest so that it can reduce its size to slide in and out the metallobox.
Thiazolylazopyrazoles as Nonsymmetric Bis‐Heteroaryl Azo Switches: High‐Yield Visible‐Light Photoisomerization and Increased Z‐Isomer Stability by o‐Carbonylation
Authors: Dang Tongtong , Dong Dongfang , Zhang Jiabin , He Yixin , Zhang Zhao‐Yang , Li Tao 
Published: March 2023

AbstractFollowing the progress on mono‐heteroaryl azo switches (Het‐N=N‐Ph), a few bis‐heteroaryl azo switches (Het‐N=N‐Het) have been studied recently, whereas the nonsymmetric bis‐heteroaryl ones (Het1‐N=N‐Het2) that can combine the respective merits of each heterocycle, have received little attention. Here we report thiazolylazopyrazoles as nonsymmetric bis‐heteroaryl azo switches that combine the visible‐light switching character of the thiazole ring and the ease of o‐substitution of the pyrazole ring. Thiazolylazopyrazoles can achieve (near‐)quantitative visible‐light isomerization in both directions and long Z‐isomer thermal half‐lives of several days. In contrast to the drastically destabilizing effect of o‐methylation, o‐carbonylation of the pyrazole ring can remarkably stabilize Z isomers by inducing attractive intramolecular interactions (dispersion, C−H⋅⋅⋅N bond, and lone‐pair⋅⋅⋅π interaction). Our work highlights the importance of the rational combination of two heterocycles and suitable structural substitution in developing bis‐heteroaryl azo switches.
Non‐Redundant Roles of T Cell Costimulation Pathways in Inflammatory Arthritis Revealed by Dual Blockade of ICOS and CD28 with Acazicolcept (ALPN‐101)
Authors: Dillon Stacey R. , Evans Lawrence S. , Lewis Katherine E. , Debrot Susan , Blair Tiffany C. , Mudri Sherri , Kleist Kayla , Levin Steven D. , Bhandari Janhavi G. , Garrett Logan , Wolfson Martin F. , Holland Pamela M. , Rixon Mark W. , Peng Stanford L. 
Published: March 2023

ObjectiveCD28 and inducible T cell costimulator (ICOS) appear to have nonredundant roles in T cell activation and adaptive immunity. We undertook this study to characterize in vitro and in vivo the therapeutic potential of acazicolcept (ALPN‐101), an Fc fusion protein of a human variant ICOS ligand (ICOSL) domain designed to inhibit both CD28 and ICOS costimulation, in inflammatory arthritis.MethodsAcazicolcept was compared in vitro with inhibitors of either the CD28 or ICOS pathways (abatacept and belatacept [CTLA‐4Ig], prezalumab [anti‐ICOSL monoclonal antibody]) in receptor binding and signaling assays, and in a collagen‐induced arthritis (CIA) model. Acazicolcept was also compared in cytokine and gene expression assays of peripheral blood mononuclear cells (PBMCs) from healthy donors or rheumatoid arthritis (RA) or psoriatic arthritis (PsA) patients stimulated with artificial antigen‐presenting cells (APCs) expressing CD28 and ICOS ligands*.ResultsAcazicolcept bound CD28 and ICOS, prevented ligand binding, and inhibited human T cell functional interactions, matching or exceeding the activity of CD28 or ICOS costimulatory single‐pathway inhibitors tested individually or in combination. Acazicolcept administration significantly reduced disease in the CIA model and more potently than abatacept. Acazicolcept also inhibited proinflammatory cytokine production from stimulated PBMCs in cocultures with artificial APCs and demonstrated unique effects on gene expression distinct from those induced by abatacept, prezalumab, or a combination of both.ConclusionBoth CD28 and ICOS signaling play critical roles in inflammatory arthritis. Therapeutic agents such as acazicolcept that coinhibit both ICOS and CD28 signaling may mitigate inflammation and/or disease progression in RA and PsA more effectively than inhibitors of either pathway alone.image