bluuebunny/crossref_metadata_2025_split huggingface dataset:
Apolipoprotein M supports S1P production and conservation and mediates prolonged Akt activation via S1PR1 and S1PR3
Authors: Kiyozuka Keisuke , Zhao Xian , Konishi Akimitsu , Minamishima Yoji Andrew , Obinata Hideru 
Published: April 2023

AbstractSphingosine 1-phosphate (S1P) is one of the lipid mediators involved in diverse physiological functions. S1P circulates in blood and lymph bound to carrier proteins. Three S1P carrier proteins have been reported, albumin, apolipoprotein M (ApoM) and apolipoprotein A4 (ApoA4). The carrier-bound S1P exerts its functions via specific S1P receptors (S1PR1-5) on target cells. Previous studies showed several differences in physiological functions between albumin-bound S1P and ApoM-bound S1P. However, molecular mechanisms underlying the carrier-dependent differences have not been clarified. In addition, ApoA4 is a recently identified S1P carrier protein, and its functional differences from albumin and ApoM have not been addressed. Here, we compared the three carrier proteins in the processes of S1P degradation, release from S1P-producing cells and receptor activation. ApoM retained S1P more stable than albumin and ApoA4 in the cell culture medium when compared in the equimolar amounts. ApoM facilitated theS1P release from endothelial cells most efficiently. Furthermore, ApoM-bound S1P showed a tendency to induce prolonged activation of Akt via S1PR1 and S1PR3. These results suggest that the carrier-dependent functional differences of S1P are partly ascribed to the differences in the S1P stability, S1P-releasing efficiency and signaling duration.
Granulomatous mastitis secondary to Corynebacterium requiring surgical intervention: a complicated diagnosis
Authors: Lu Charles , Marcucci Vincent , Kibbe Erica , Patel Roshani 
Published: April 2023

Abstract
Corynebacterium species is a Gram-positive bacillus endogenous to human integument that has previously been associated with idiopathic granulomatous mastitis. The diagnosis and treatment of this bacteria may be complicated by inability to distinguish colonization from contamination and infection. We present an uncommon case of granulomatous mastitis associated with negative wound cultures requiring surgical intervention.
Heparin Concentration in Evacuated Tubes and Its Effect on pH, Ionized Calcium, Lactate, and Potassium in Venous Blood Gas Analysis
Authors: Mahler Katherine , Kerlin Rae , Jones JoAnna , Li Jieli 
Published: April 2023

AbstractArterial blood specimens collected in evacuated tubes are unacceptable for blood gas analysis. However, evacuated tubes are routinely used for venous blood-gas analysis. The impact of the blood to heparin ratio on venous blood in evacuated tubes is unclear. Venous blood was drawn into lithium and sodium heparin evacuated tubes that were 1/3 full, ½ full, 2/3 full, and fully filled. Specimens were analyzed for pH, ionized calcium (iCa), lactate, and potassium on a blood-gas analyzer. The results for specimens filled only 1/3 full for lithium and sodium heparin tubes revealed a significant increase in pH and a significant decrease in the iCa. Underfilling the lithium and sodium heparin evacuated tubes did not significantly impact the lactate or potassium results. Venous whole-blood specimens should be filled to at least 2/3 full for accurate pH and iCa results.
Provenance visualization: Tracing people, processes, and practices through a data-driven approach to provenance
Authors: Vancisin Tomas , Clarke Loraine , Orr Mary , Hinrichs Uta 
Published: April 2023

Abstract
Provenance disclosure—the documentation of an artifact’s origin and how it was produced—is an important aspect to consider when working with historical records which undergo multiple transformations in preparation for and during digitization. Provenance in this context is commonly communicated through explanatory text or static diagrams. However, the methodological and curatorial decisions that have influenced the records’ data are easily overlooked, in particular when exploring the records through visualization as a result of digitization processes. We propose a data-driven approach to provenance disclosure which (1) traces provenance back to when the records were created, (2) documents and categorizes the records’ transformations (transcriptions, content modifications, changes in organization, and representational form), and (3) uses data visualization to disclose provenance in interactive ways. We reflect on how this approach can be practically applied in the context of historical record collections, and we present findings from a qualitative study we conducted to investigate the merits and limitations of provenance-driven visualization. Our findings suggest that data-driven provenance disclosure has the potential to (1) promote transparency and deeper interpretations of historical records, (2) provide rigor in researching historical document collections and underlying production processes, and (3) encourage ethical considerations by making visible labor and implicit bias that influence the production and curation of historical records.
Radio AGN selection and characterization in three Deep-Drilling Fields of the Vera C. Rubin Observatory Legacy Survey of Space and Time
Authors: Zhu Shifu , Brandt W N , Zou Fan , Luo Bin , Ni Qingling , Xue Yongquan , Yan Wei 
Published: April 2023

ABSTRACT
The Australia Telescope Large Area Survey (ATLAS) and the VLA survey in the XMM-LSS/VIDEO deep field provide deep (≈15 $\mu$ Jy beam−1) and high-resolution (≈4.5–8 arcsec) radio coverage of the three XMM-SERVS fields (W-CDF-S, ELAIS-S1, and XMM-LSS). These data cover a total sky area of 11.3 deg2 and contain ≈11 000 radio components. Furthermore, about 3 deg2 of the XMM-LSS field also has deeper MIGHTEE data that achieve a median RMS of 5.6 $\mu$ Jy beam−1 and detect more than 20 000 radio sources. We analyse all these radio data and find source counterparts at other wavebands utilizing deep optical and infrared (IR) surveys. The nature of these radio sources is studied using radio-band properties (spectral slope and morphology) and the IR–radio correlation. Radio AGNs are selected and compared with those selected using other methods (e.g. X-ray). We found 1656 new AGNs that were not selected using X-ray and/or MIR methods. We constrain the FIR-to-UV SEDs of radio AGNs using cigale and investigate the dependence of radio AGN fraction upon galaxy stellar mass and star formation rate.
Exploring the impact of IMF and binary parameter stochasticity with a binary population synthesis code
Authors: Stanway Elizabeth R , Eldridge J J 
Published: April 2023

ABSTRACT
Low-mass star formation regions are unlikely to fully populate their initial mass functions (IMFs), leading to a deficit of massive stars. In binary stellar populations, the full range of binary separations and mass ratios will also be underpopulated. To explore the effects of stochastic sampling in the integrated light of stellar clusters, we calculate models at a broad range of cluster masses, from 102 to 107 M⊙, using a binary stellar population synthesis code. For clusters with stellar masses less than 105 M⊙, observable quantities show substantial scatter and their mean properties reflect the expected deficit of massive stars. In common with previous work, we find that purely stochastic sampling of the IMF appears to underestimate the mass of the most massive star in known clusters. However, even with this constraint, the majority of clusters likely inject sufficient kinetic energy to clear their birth clusters of gas. For quantities that directly measure the impact of the most massive stars, such as Nion, ξion, and βUV, uncertainties due to stochastic sampling dominate over those from the IMF shape or distribution of binary parameters, while stochastic sampling has a negligible effect on the stellar continuum luminosity density.
High-fidelity reproduction of central galaxy joint distributions with neural networks
Authors: Rodrigues Natália V N , de Santi Natalí S M , Montero-Dorta Antonio D , Abramo L Raul 
Published: April 2023

ABSTRACT
The relationship between galaxies and haloes is central to the description of galaxy formation and a fundamental step towards extracting precise cosmological information from galaxy maps. However, this connection involves several complex processes that are interconnected. Machine Learning methods are flexible tools that can learn complex correlations between a large number of features, but are traditionally designed as deterministic estimators. In this work, we use the IllustrisTNG300-1 simulation and apply neural networks in a binning classification scheme to predict probability distributions of central galaxy properties, namely stellar mass, colour, specific star formation rate, and radius, using as input features the halo mass, concentration, spin, age, and the overdensity on a scale of 3 h−1 Mpc. The model captures the intrinsic scatter in the relation between halo and galaxy properties, and can thus be used to quantify the uncertainties related to the stochasticity of the galaxy properties with respect to the halo properties. In particular, with our proposed method, one can define and accurately reproduce the properties of the different galaxy populations in great detail. We demonstrate the power of this tool by directly comparing traditional single-point estimators and the predicted joint probability distributions, and also by computing the power spectrum of a large number of tracers defined on the basis of the predicted colour–stellar mass diagram. We show that the neural networks reproduce clustering statistics of the individual galaxy populations with excellent precision and accuracy.
POLAR - I: linking the 21-cm signal from the epoch of reionization to galaxy formation
Authors: Ma Qing-Bo , Ghara Raghunath , Ciardi Benedetta , Iliev Ilian T , Koopmans Léon V E , Mellema Garrelt , Mondal Rajesh , Zaroubi Saleem 
Published: April 2023

ABSTRACT
To self-consistently model galactic properties, reionization of the intergalactic medium, and the associated 21-cm signal, we have developed the algorithm polar by integrating the one-dimensional radiative transfer code grizzly with the semi-analytical galaxy formation code L-Galaxies 2020. Our proof-of-concept results are consistent with observations of the star formation rate history, UV luminosity function, and the CMB Thomson scattering optical depth. We then investigate how different galaxy formation models affect UV luminosity functions and 21-cm power spectra, and find that while the former are most sensitive to the parameters describing the merger of haloes, the latter have a stronger dependence on the supernovae feedback parameters, and both are affected by the escape fraction model.
Hydrodynamic evolution of Sgr A East: the imprint of a supernova remnant in the Galactic Centre
Authors: Zhang Mengfei , Li Zhiyuan , Hua Ziqian , Morris Mark R 
Published: April 2023

ABSTRACTWe perform three-dimensional numerical simulations to study the hydrodynamic evolution of Sgr A East, the only known supernova remnant (SNR) in the centre of our Galaxy, to infer its debated progenitor supernova (SN) type and its potential impact on the Galactic Centre environment. Three sets of simulations are performed, each of which represents a certain type of SN explosion (SN Iax, SN Ia, or core-collapse SN) expanding against a nuclear outflow of hot gas driven by massive stars, whose thermodynamical properties have been well established by previous work and fixed in the simulations. All three simulations can simultaneously roughly reproduce the extent of Sgr A East and the position and morphology of an arc-shaped thermal X-ray feature, known as the ‘ridge’. Confirming previous work, our simulations show that the ridge is the manifestation of a strong collision between the expanding SN ejecta and the nuclear outflow. The simulation of the core-collapse SN, with an assumed explosion energy of 5 × 1050 erg and an ejecta mass of 10 M⊙, can well match the X-ray flux of the ridge, whereas the simulations of the SN Iax and SN Ia explosions underpredict its X-ray emission, due to a smaller ejecta mass. All three simulations constrain the age of Sgr A East to be ≲1500 yr and predict that the ridge should fade out over the next few hundred years. We address the implications of these results for our understanding of the Galactic Centre environment.
Systematic errors in the maximum-likelihood regression of Poisson count data: introducing the overdispersed χ2 distribution
Authors: Bonamente Massimiliano 
Published: April 2023

ABSTRACT
This paper presents a new method to estimate systematic errors in the maximum-likelihood regression of count data. The method is applicable in particular to X-ray spectra in situations where the Poisson log-likelihood, or the Cash goodness-of-fit statistic, indicate a poor fit that is attributable to overdispersion of the data. Overdispersion in Poisson data is treated as an intrinsic model variance that can be estimated from the best-fit model, using the maximum-likelihood Cmin statistic. The paper also studies the effects of such systematic errors on the ΔC likelihood-ratio statistic, which can be used to test for the presence of a nested model component in the regression of Poisson count data. The paper introduces an overdispersed χ2 distribution that results from the convolution of a χ2 distribution that models the usual ΔC statistic, and a zero-mean Gaussian that models the overdispersion in the data. This is proposed as the distribution of choice for the ΔC statistic in the presence of systematic errors. The methods presented in this paper are applied to XMM–Newton data of the quasar 1ES 1553+113 that were used to detect absorption lines from an intervening warm-hot intergalactic medium (WHIM). This case study illustrates how systematic errors can be estimated from the data, and their effect on the detection of a nested component, such as an absorption line, with the ΔC statistic.
Cerebral oxygenation during exercise deteriorates with advancing chronic kidney disease
Authors: Theodorakopoulou Marieta P , Dipla Konstantina , Zafeiridis Andreas , Faitatzidou Danai , Koutlas Aggelos , Doumas Michael , Papagianni Aikaterini , Sarafidis Pantelis 
Published: April 2023

ABSTRACT

Background
Cognitive impairment and exercise intolerance are common in chronic kidney disease (CKD). Cerebral perfusion and oxygenation play a major role in both cognitive function and exercise execution. This study aimed to examine cerebral oxygenation during a mild physical stress in patients at different CKD stages and controls without CKD.

Methods
Ninety participants (18 per CKD stage 2, 3a, 3b and 4 and 18 controls) underwent a 3-min intermittent handgrip exercise at 35% of their maximal voluntary contraction. During exercise, cerebral oxygenation [oxyhaemoglobin (O2Hb), deoxyhaemoglobin (HHb) and total haemoglobin (tHb)] was assessed by near-infrared spectroscopy. Indices of microvascular (muscle hyperaemic response) and macrovascular function (carotid intima-media thickness and pulse wave velocity (PWV)) and cognitive and physical activity status were also evaluated.

Results
No differences in age, sex and body mass index were detected among groups. The mini-mental state examination score was significantly reduced with advancing CKD stages (controls: 29.2 ± 1.2, stage 2: 28.7 ± 1.0, stage 3a: 27.8 ± 1.9, stage 3b: 28.0 ± 1.8, stage 4: 27.6 ± 1.5; P = .019). Similar trends were observed for physical activity levels and handgrip strength. The average response in cerebral oxygenation (O2Hb) during exercise was lower with advancing CKD stages (controls: 2.50 ± 1.54, stage 2: 1.30 ± 1.05, stage 3a: 1.24 ± 0.93, stage 3b: 1.11 ± 0.89, stage 4: 0.97 ± 0.80 μmol/l; P &lt; .001). The average tHb response (index of regional blood volume) showed a similar decreasing trend (P = .003); no differences in HHb among groups were detected. In univariate linear analysis, older age, lower estimated glomerular filtration rate (eGFR), Hb, microvascular hyperaemic response and increased PWV were associated with poor O2Hb response during exercise. In the multiple model, eGFR was the only parameter independently associated with the O2Hb response.

Conclusions
Brain activation during a mild physical task appears to decrease with advancing CKD as suggested by the smaller increase in cerebral oxygenation. This may contribute to impaired cognitive function and reduced exercise tolerance with advancing CKD.
Enhanced dominance of soil moisture stress on vegetation growth in Eurasian drylands
Authors: Zhang Yu , Zhang Yangjian , Lian Xu , Zheng Zhoutao , Zhao Guang , Zhang Tao , Xu Minjie , Huang Ke , Chen Ning , Li Ji , Piao Shilong 
Published: April 2023

ABSTRACT
Despite the mounting attention being paid to vegetation growth and their driving forces for water-limited ecosystems, the relative contributions of atmospheric and soil moisture dryness stress on vegetation growth are an ongoing debate. Here we comprehensively compare the impacts of high vapor pressure deficit (VPD) and low soil water content (SWC) on vegetation growth in Eurasian drylands during 1982–2014. The analysis indicates a gradual decoupling between atmospheric dryness and soil dryness over this period, as the former has expanded faster than the latter. Moreover, the VPD–SWC relation and VPD–greenness relation are both non-linear, while the SWC–greenness relation is near-linear. The loosened coupling between VPD and SWC, the non-linear correlations among VPD–SWC-greenness and the expanded area extent in which SWC acts as the dominant stress factor all provide compelling evidence that SWC is a more influential stressor than VPD on vegetation growth in Eurasian drylands. In addition, a set of 11 Earth system models projected a continuously growing constraint of SWC stress on vegetation growth towards 2100. Our results are vital to dryland ecosystems management and drought mitigation in Eurasia.
Effect of xanthophyll-rich food and supplement intake on visual outcomes in healthy adults and those with eye disease: a systematic review, meta-analysis, and meta-regression of randomized controlled trials
Authors: Hu Weili , Shankar Pavitra , Yao Yuanhang , Su Xinyi , Kim Jung Eun 
Published: April 2023

Abstract

Context
Xanthophyll intake is known to improve eye health; however, its benefits on visual outcomes have not been systematically studied, particularly in a population with eye diseases.

Objective
A systematic review, meta-analysis, and meta-regression were conducted to investigate the effect of xanthophyll intake on visual outcomes, and further subgroup analysis was performed on the basis of eye disease status.

Data Sources
The PubMed, Scopus, Embase, CINAHL, Cochrane, and Web of Science databases were searched, and relevant randomized controlled trials were identified.

Data Extraction
For systematic review, meta-analysis, and meta-regression, 43, 25, and 21 articles were selected, respectively.

Data Analysis
Xanthophyll intake enhanced macular pigment optical density (MPOD) for both heterochromatic flicker photometry (weighted mean difference [WMD], 0.05; 95% confidence interval [CI], 0.03–0.07) and autofluorescence imaging (WMD, 0.08; 95%CI, 0.05–0.11) measurements and decreased photostress recovery time (WMD, –2.35; 95%CI, –4.49 to –0.20). While enhancement in visual acuity logarithm of the minimum angle of resolution was observed in response to the xanthophyll-rich food and supplement intake only for patients with eye disease (WMD, –0.04; 95%CI, –0.07 to –0.01). Meta-regression showed a positive correlation between change in MPOD (heterochromatic flicker photometry) and the corresponding change in serum lutein levels (regression coefficient = 0.068; P = 0.00).

Conclusion
Intake of xanthophyll-rich food or supplements can improve eye health. Additional improvement in visual acuity was observed in patients with eye disease. A positive association between MPOD and serum lutein level, while absent with dietary xanthophyll intake, suggests the importance of bioavailability when examining the effect of xanthophyll on eye health.

Systematic Review Registration
PROSPERO registration no. CRD42021295337.
Three-Year Outcomes Following Permissive Cardiotoxicity in Patients on Trastuzumab
Authors: Zhou Shijie , Cirne Filipe , Chow Justin , Zereshkian Arman , Bordeleau Louise , Dhesy-Thind Sukhbinder , Ellis Peter M , Mukherjee Som D , Aghel Nazanin , Leong Darryl P 
Published: April 2023

Abstract

Introduction
Cardiotoxicity, manifest by reduced left ventricular ejection fraction (LVEF), is the most common reason for the premature discontinuation of trastuzumab. While permissive cardiotoxicity (where mild cardiotoxicity is accepted to enable ongoing trastuzumab) has been shown feasible, the longer-term outcomes are unknown. We aimed to study the intermediate-term clinical outcomes of patients who underwent permissive cardiotoxicity.

Materials and Methods
We performed a retrospective cohort study of patients referred to the cardio-oncology service at McMaster University from 2016 to 2021 for LV dysfunction following trastuzumab administration.

Results
Fifty-one patients underwent permissive cardiotoxicity. The median (25th-75th percentile) follow-up time from cardiotoxicity onset was 3 years (1.3-4 years). Forty-seven (92%) patients completed trastuzumab; 3 (6%) developed severe LV dysfunction or clinical heart failure (HF) while on trastuzumab and prematurely discontinued therapy. One discontinued trastuzumab by patient choice. At final follow-up after therapy completion, 7 (14%) patients still had mild cardiotoxicity, including 2 who had clinical heart failure and stopped trastuzumab early. Among those with recovered LV function, 50% had normalized LVEF or GLS by 6 and 3 months, respectively, after initial cardiotoxicity. There was no difference in characteristics between those who did or did not recover their LV function.

Conclusions
Among patients exposed to permissive trastuzumab cardiotoxicity for HER2-positive breast cancer, 6% were unable to complete planned trastuzumab due to severe LV dysfunction or clinical HF. Although most patients recover their LV function after trastuzumab discontinuation or completion, 14% still have persistent cardiotoxicity by 3-year follow-up.
Hierarchical regulatory module GENOMES UNCOUPLED1-GOLDEN2-LIKE1/2-WRKY18/40 modulates salicylic acid signaling
Authors: Lee Keun Pyo , Li Mengping , Li Mengshuang , Liu Kaiwei , Medina-Puche Laura , Qi Shan , Cui Chaojun , Lozano-Duran Rosa , Kim Chanhong 
Published: April 2023

AbstractChloroplast-to-nucleus retrograde signaling (RS) pathways are critical in modulating plant development and stress adaptation. Among chloroplast proteins mediating RS pathways, GENOMES UNCOUPLED1 (GUN1) represses the transcription of the nuclear transcription factors GOLDEN2-LIKE1 (GLK1) and GLK2 that positively regulate chloroplast biogenesis. Given the extensive exploration of the function of GUN1 in biogenic RS carried out in previous years, our understanding of its role in plant stress responses remains scarce. Here, we revealed that GUN1 contributes to the expression of salicylic acid (SA)-responsive genes (SARGs) through transcriptional repression of GLK1/2 in Arabidopsis (Arabidopsis thaliana). Loss of GUN1 significantly compromised the SA responsiveness in plants, concomitant with the upregulation of GLK1/2 transcripts. In contrast, knockout of GLK1/2 potentiated the expression of SARGs and led to enhanced stress responses. Chromatin immunoprecipitation, coupled with quantitative PCR and related reverse genetic approaches, unveiled that in gun1, GLK1/2 might modulate SA-triggered stress responses by stimulating the expression of WRKY18 and WRKY40, transcriptional repressors of SARGs. In summary, we demonstrate that a hierarchical regulatory module, consisting of GUN1-GLK1/2-WRKY18/40, modulates SA signaling, opening a research avenue regarding a latent GUN1 function in plant–environment interactions.