bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Use of Pregelatinized Sweetcorn (Zea mays Saccharata Sturt.) in The Production of Instant Corn Bakwan flour Mix
Authors: Panjaitan Robert Pardomuan , Kartikawati Diah , Dyah Ilminingtyas WH. 
Published: May 2023

Abstract
Instant corn bakwan flour is a mixture of various flours with mixed spices so that it is practical in its production. This study aimed to determine the effect of pregelatinized sweet corn flour substitution on the physicochemical properties of instant corn bakwan flour. The research method used a completely randomized design (CRD) with 6 treatments, namely the substitution of pregelatinized sweet corn flour 0% as a control (T0), 5% (T1), 10% (T2), 15% (T3), 20% (T4), and 25% (T5). Each treatment was repeated 3 times. The data obtained were processed using statistical tests and further tests using Duncan Multiple Range Test (DMRT). The results of this research on the physical properties of instant corn bakwan flour showed the value of bulk density ranged from 0,77-0,79 g/ml, water absorption capacity of 165,67-187,67%, and solubility of 74,67-88,50%. The results of the chemical properties showed that the water content ranged from 10,67-11,67%, the ash content was 0,58-1,08%, the fat content wash 1,03-4,73%, the protein content was 9,65-10,49%, and carbohydrate content of 73,53-77,15%.. The substitution of pregelatinized sweet corn flour increased water absorption and solubility, protein content, fat content and β carotene of instant corn bakwan flour.
Veterans Health Administration: Implementation of pharmacogenomic clinical decision support with statin medications and the SLCO1B1 gene as an exemplar
Authors: Tomcsanyi Kelly M , Tran Kelvin A , Bates Jill , Cunningham Francesca E , Silverman Robert , Norris Amy K , Moore Von R , Voora Deepak 
Published: May 2023

Abstract

Purpose
To describe the implementation of clinical decision support tools for alerting prescribers of actionable drug-gene interactions in the Veterans Health Administration (VHA).

Summary
Drug-gene interactions have been the focus of clinicians for years. Interactions between SCLO1B1 genotype and statin medications are of particular interest as these can inform risk for statin-associated muscle symptoms (SAMS). VHA identified approximately 500,000 new users of statin medications prescribed in VHA in fiscal year 2021, some of whom could benefit from pharmacogenomic testing for the SCLO1B1 gene. In 2019, VHA implemented the Pharmacogenomic Testing for Veterans (PHASER) program to offer panel-based, preemptive pharmacogenomic testing and interpretation. The PHASER panel includes SLCO1B1, and VHA utilized Clinical Pharmacogenomics Implementation Consortium statin guidelines to build its clinical decision support tools. The program’s overarching goal is to reduce the risk of adverse drug reactions such as SAMS and improve medication efficacy by alerting practitioners of actionable drug-gene interactions. We describe the development and implementation of decision support for the SLCO1B1 gene as an example of the approach being used for the nearly 40 drug-gene interactions screened for by the panel.

Conclusion
The VHA PHASER program identifies and addresses drug-gene interactions as an application of precision medicine to reduce veterans’ risks for adverse events. The PHASER program’s implementation of statin pharmacogenomics utilizes a patient’s SCLO1B1 phenotype to alert providers of the risk for SAMS with the statin being prescribed and how to lower that risk through a lower dose or alternative statin selection. The PHASER program may help reduce the number of veterans who experience SAMS and may improve their adherence to statin medications.
Common Factor Structure of the Ten Subtest Wechsler Adult Intelligence Scale–Fourth Edition in a Clinical Sample and 15 Subtest Version in the Standardization Sample
Authors: Sudarshan Navaneetham J , Bowden Stephen C 
Published: May 2023

Abstract

Objective
The 10 core subtests of the Wechsler Adult Intelligence Scale-IV (WAIS-IV) suffice to produce the 4 index scores for clinical assessments. Factor analytic studies with the full complement of 15 subtests reveal a 5-factor structure that aligns with Cattell–Horn–Carroll taxonomy of cognitive abilities. The current study investigates the validity of 5-factor structure in a clinical setting with reduced number of 10 subtests.

Method
Confirmatory factor analytic models were fitted to a clinical neurosciences archival data set (n_Male = 166, n_Female = 155) and to 9 age-group samples of the WAIS-IV standardization data (n = 200 for each group). The clinical and the standardization samples differed as (a) the former comprised scores from patients, aged 16 to 91, with disparate neurological diagnosis whereas the latter was demographically stratified, (b) only the 10 core subtests in the former but all 15 subtests in the latter were administered, and (c) the former had missing data, but the latter was complete.

Result
Despite empirical constraints to eliciting 5 factors with only 10 indicators, the well-fitting, 5-factor (acquired knowledge, fluid intelligence, short-term memory, visual processing, and processing speed) measurement model evinced metric invariance between the clinical and standardization samples.

Conclusion
The same cognitive constructs are measured on the same metrics in every sample examined and provide no reason to reject the assumption that the 5 underlying latent abilities of the 15 subtest version in the standardization samples can also be inferred from the 10 subtest version in clinical populations.
Effect of Vinegar on the Oxidative Stability of Mayonnaise During its Storage
Authors: Alnokkari Afraa 
Published: May 2023

Abstract
Mayonnaise is an emulsion of oil that is susceptible to lipid oxidation, which can cause spoilage and the formation of harmful compounds. This study aims to evaluate the impact of Syrian apple and grape vinegar on the oxidative stability of mayonnaise and compare the use of natural antioxidants to synthetic ones such as butylated hydroxyanisole and butylated hydroxytoluene. The study measured total phenol content, radical scavenging activity, and identified some phenolic compounds by High Performance Liquid Chromatography (HPLC). The rancidity of mayonnaise was examined using peroxide value and thiobarbituric acid number. The fatty acids content in the mayonnaise samples was examined using gas chromatography. Vinegar samples containing high concentrations of phenolic antioxidants showed high ability to scavenge free radicals. The antioxidants in vinegar protected the mayonnaise samples from primary and secondary oxidation, and there was no statistically significant difference between the ratio of unsaturated fatty acids in the samples containing vinegar at the beginning and at the end of the storage period. The study shows the significance of using vinegar to protect mayonnaise from deterioration and increase its shelf life, in addition to its role as a dressing.
Joan Robinson and the reconstruction of economic theory
Authors: Martins Nuno Ornelas 
Published: May 2023

Abstract
Joan Robinson provided numerous contributions to economic theory, ranging from her earlier approach to imperfect competition to her participation in the Keynesian revolution, which had a significant influence in the Cambridge heterodox wing, and Post-Keynesianism. But towards the end of her life, her rejection of received theories was great enough to be often interpreted as a form of theoretical nihilism. However, at this stage she also outlined a radical project for a reconstruction of economic theory, drawing on her notion of historical time, while placing distribution at the centre of economic theory. This later project of a reconstruction of economic theory is revisited here, focussing on the various difficulties it faced, and its overall significance and impact.
Non-monetary incentives to increase enrollment in payments for environmental services
Authors: Chabé-Ferret Sylvain , Le Coent Philippe , David-Legleye Valentin , Delannoy Véronique 
Published: May 2023

Abstract
Payments for Environmental Services (PESs) are increasingly used to foster farmers’ adoption of greener practices, but their effectiveness is often undermined by low enrollment. In a large randomized field experiment (N = 20,000), we test several non-monetary incentives to increase enrollment into the French implementation of the Agri-Environmental Schemes program of the European Union. We find that sending 10,000 information letters triggers the enrollment of 75 ± 52 farmers at a cost of 102 $\pm\ $71 Euros/new enrollee. Pre-stamped reply forms increase contacts with caseworkers but fail to raise enrollment. Testimonies by other farmers seem to decrease the effectiveness of the letters. Diffusion effects could increase the impact of our non-monetary incentives by 40% to 50% and decrease the cost of an additional enrollee by around 30%.
Pre-hospital delay, clinical characteristics, angiographic findings, and in-hospital mortality in young and middle-aged adults with acute coronary syndrome: a single-centre registry analysis
Authors: Bauer Dávid , Neuberg Marek , Nováčková Markéta , Kočka Viktor , Toušek Petr 
Published: May 2023

Abstract
There are several differences between younger and older adults with acute coronary syndrome (ACS). However, few studies have evaluated these differences. We analysed the pre-hospital time interval [symptom onset to first medical contact (FMC)], clinical characteristics, angiographic findings, and in-hospital mortality in patients aged ≤50 (group A) and 51–65 (group B) years hospitalised for ACS. We retrospectively collected data from 2010 consecutive patients hospitalised with ACS between 1 October 2018 and 31 October 2021 from a single-centre ACS registry. Groups A and B included 182 and 498 patients, respectively. ST-segment elevation myocardial infarction (STEMI) was more common in group A than group B (62.6 and 45.6%, respectively; P &lt; 0.001). The median time from symptom onset to FMC in STEMI patients did not significantly differ between groups A and B [74 (40–198) and 96 (40–249) min, respectively; P = 0.369]. There was no difference in the rate of sub-acute STEMI (symptom onset to FMC &gt; 24 h) between groups A and B (10.4% and 9.0%, respectively; P = 0.579). Among patients with non-ST elevation acute coronary syndrome (NSTE-ACS), 41.8 and 50.2% of those in groups A and B, respectively, presented to the hospital within 24 h of symptom onset (P = 0.219). The prevalence of previous myocardial infarction was 19.2% in group A and 19.5% in group B (P = 1.00). Hypertension, diabetes, and peripheral arterial disease were more common in group B than group A. Active smoking was more common in group A than group B (67 and 54.2%, respectively; P = 0.021). Single-vessel disease was present in 52.2 and 37.1% of participants in groups A and B, respectively (P = 0.002). Proximal left anterior descending artery was more commonly the culprit lesion in group A compared with group B, irrespective of the ACS type (STEMI, 37.7 and 24.2%, respectively; P = 0.009; NSTE-ACS, 29.4 and 21%, respectively; P = 0.140). The hospital mortality rate for STEMI patients was 1.8 and 4.4% in groups A and B, respectively (P = 0.210), while for NSTE-ACS patients it was 2.9 and 2.6% in groups A and B, respectively (P = 0.873). No significant differences in pre-hospital delay were found between young (≤50 years) and middle-aged (51–65 years) patients with ACS. Although clinical characteristics and angiographic findings differ between young and middle-aged patients with ACS, the in-hospital mortality rate did not differ between the groups and was low for both of them.
Effectiveness of a Sedentary Behaviour Intervention as a Personalised Secondary Prevention Strategy (SIT LESS) for patients with coronary artery disease: primary outcomes of the SIT LESS trial
Authors: Van Bakel B M A , Kroesen S H , Bakker E A , Van Miltenburg R V , Gunal A , Scheepmaker A , Aengevaeren W R M , Willems F F , Wondergem R , Pisters M F , De Bruin M , Hopman M T E , Thijssen D H J , Eijsvogels T M H 
Published: May 2023

Abstract

Funding Acknowledgements
Type of funding sources: Foundation. Main funding source(s): Dutch Heart Foundation.

Background
High levels of time spent sedentary are associated with increased risk of cardiovascular disease morbidity and mortality, even after accounting for traditional risk factors. A sedentary lifestyle is highly prevalent among patients with coronary artery disease (CAD).

Purpose
This clinical trial aimed to determine whether a multicomponent, hybrid (center- and home-based), sedentary behaviour change intervention as a personalized secondary prevention strategy (SIT LESS) reduces daily sedentary time among patients with CAD participating in cardiac rehabilitation.

Methods
Patients were randomised to usual care (n=104) or SIT LESS (n=108). Both groups received a comprehensive 12-week centre-based cardiac rehabilitation programme with face-to-face consultations and supervised exercise sessions, whereas SIT LESS participants additionally received a 12-week, nurse-delivered, hybrid behaviour change intervention in combination with an activity tracker connected to a smartphone application. Primary outcome was the change in objectively measured sedentary time between pre- to post-rehabilitation.

Results
Patients (77% male) were 63±10 years and primarily diagnosed with myocardial infarction (78%). Sedentary time decreased in SIT LESS (−1.6 [−2.1 to −1.1] hours/day) and controls (−1.2 [ ─1.7 to −0.8]), but between group differences did not reach statistical significance (─0.4 [─1.0 to 0.3]) hours/day, Central Figure). The post-rehabilitation proportion of patients with a sedentary time above the upper limit of normal (≥9.5 hours/day) was significantly lower in SIT LESS versus controls (48% versus 72%, baseline-adjusted odds-ratio 0.4 (0.2-0.8)). No differences were observed in the other predefined secondary outcomes.

Conclusions
Among patients with coronary artery disease participating in cardiac rehabilitation, SIT LESS did not induce significantly greater reductions in sedentary time compared to controls, but delivery was feasible and a reduced odds of a sedentary time ≥9.5 hours/day was observed.
Rapid improvements in physical (in)activity patterns in patients with myocardial infarction immediately following hospital discharge
Authors: Van Bakel B M A , De Koning I A , Bakker E A , Pop G A M , Cramer G E , Van Geuns R J M , Thijssen D H J , Eijsvogels T M H 
Published: May 2023

Abstract

Funding Acknowledgements
Type of funding sources: Foundation. Main funding source(s): Dutch Heart Foundation.

Background
Physical activity counselling plays a pivotal role in recovery after myocardial infarction (MI), but little is known about changes in physical activity (PA) and sedentary behaviour (SB) patterns in the acute phase post MI.

Purpose
This study aimed to objectively assess PA and SB during hospitalisation and during the first week post-discharge and to identify whether potential changes in PA patterns differed based on sex, age, need for coronary artery bypass grafting (CABG), presence of ST-elevated myocardial infarction (STEMI), and level of cardiac anxiety.

Methods
Consecutively admitted patients hospitalised with an MI were approached to participate in this prospective cohort study. SB, light-intensity PA (LIPA) and moderate-vigorous PA (MVPA) were objectively assessed for 24 h/day during hospitalisation and up to 7 days post-discharge in 165 patients. Changes in PA and SB upon the transition from the hospital to home were evaluated using mixed model analyses and outcomes were stratified for predefined subgroups based on patient characteristics.

Results
Patients (78% male) were 65±10 years and diagnosed with STEMI (50%) or NSTEMI (50%). Sedentary time was high during hospitalisation (12.6 [11.8-13.7] h/day), but substantially decreased following transition to the home environment (−1.8 (−2.4 to −1.3) h/day) (Central Figure). The number of prolonged sedentary bouts (≥60 min) decreased between hospital and home (−1.6 (95%CI −2.0; −1.2) bouts/day). LIPA (1.1 [0.8-1.6] h/day) and MVPA (0.2 [0.1-0.3] h/day) were low during hospitalisation, but significantly increased following transition to the home environment (LIPA: +1.8 (1.4 to 2.3) h/day; MVPA: +0.4 (0.3 to 0.5) h/day, both p&lt;0.001). Improvements in PA and SB were similar across groups, except for CABG patients who did not alter their PA patterns post-discharge.

Conclusions
Patients with MI demonstrate high levels of sedentary behaviour and low physical activity volumes during hospitalisation, which immediately improved following discharge at the patient’s home environment.
Family screening in inherited cardiac conditions: predicting likelihood of a diagnosis
Authors: Abela M , Felice T , Sammut M A , Debattista J , Scerri J , Scerri C , Grech V 
Published: May 2023

Abstract

Funding Acknowledgements
Type of funding sources: Private grant(s) and/or Sponsorship. Main funding source(s): Cardiovascular Research Scholarship awarded by 'Research, Innovation and Development Trust (University of Malta)', kindly donated by Beating Hearts Malta.
Scholarship awarded by Tertiary Education Scholarship Scheme.

Introduction
Family screening is an important pillar in inherited cardiac conditions (ICC), yet the likelihood of disease in screened relatives is difficult to predict. The objective of this study was to create a clinical score to help predict the likelihood of a diagnosis in relatives undergoing screening.

Methodology
The BEAT-IT national cardiac screening program enrolled 2708 adolescents (14-16 years). Families of probands with a preclinical or clinical diagnosis were offered cardiac screening. Those with an abnormal preliminary screen were further evaluated. Data was analyzed with SPSS v23 using chi squared. P&lt;0.05 was considered statistically significant.

Results
A total of 19 families were evaluated, 81 family members (60.5% female, mean age 41.1±16.7 at evaluation) underwent cardiac screening because of a preclinical (n=17, 89.4%) or clinical (n=1 HCM, n=1 LQTS) phenotype in the index case. Some (n=8, 9.9%) were labelled with a clinical phenotype (n=5 LQTS, n=2 HCM, n=1 DCM). The highest diagnostic yield was in long QT (55.6%) and HCM (50.0%) probands. All relatives were asymptomatic.
Several factors increased the likelihood of a relative being given a diagnosis at screening. The i) presence of a proband phenotype (p&lt;0.001), ii) abnormal screening ECG (p&lt;0.001), iii) abnormal echocardiography suggestive of an ICC (p&lt;0.001), iv) low ejection fraction (p=0.043), v) fibrosis on MRI (p=0.035), vi) likely or definite pathogenic mutation in the proband (p&lt;0.001) and vii) a gene positive relative (p&lt;0.001) were all significantly predictive. Age at evaluation, gender, family history of sudden cardiac death and arrhythmias at screening were not predictive. A relative with ≥3 variables had a higher probability of a clinical diagnosis (72.7% vs 0%, p&lt;0.001).

Conclusion
A combined clinical and genetic evaluation was able to identify an ICC in 9.9% of screened family members. The presence of ≥3 clinical variables at screening was linked to a higher probability of a diagnosis in relatives. A comprehensive evaluation in relatives with a suspicion of an ICC is necessary useful for diagnostic purposes.
DNA methylation as a biomarker for cardiometabolic disease risk
Authors: Janovska J , Nixdorff U N , Voicehovska J V 
Published: May 2023

Abstract

Funding Acknowledgements
Type of funding sources: None.
Cardiovascular disease (CVD) is the leading cause of death in most countries [1]. Risk factors known to predispose to the development of CVD include increasing age, male gender, diabetes mellitus, high blood cholesterol, tobacco smoking, high blood pressure (hypertension), obesity, physical inactivity, and family history [2]. Elevated plasma homocysteine is also an independent risk factor for CVD [2,3]. The mechanism by which elevated homocysteine contributes to CVD risk is not well understood, but it is well-established that dietary folate and vitamin B supplementation can reduce serum homocysteine levels by facilitating remethylation of homocysteine to methionine [4]. DNA methylation can modulate gene expression in response to exposure to various substances, such as nutrients, smoking, and environmental chemicals.Variation in healthy aging and lifespan is ascribed more to various non-genetic factors than to inherited genetic determinants, and a major goal in aging research is to reveal the epigenetic basis of aging. The remethylation cycle is essential for the systemic methyl donor supply, which is used for important biological processes, such as cytosine-5 methylation of genomic DNA, an epigenetic modification that plays an important role in maintaining genomic stability, chromatin structure, and in controlling transcriptional capacity [2,4].

Methodology/Principal Findings
In this prospective study, we examined both gender patients, aged 40-50 years. Relationship between prevalence of Cardiometabolic risk factors (metabolic syndrome, oxidative stress and arterial hypertension) or its predisposing conditions (hypertrigliceridemia, dislipedimia, inusline resistance, D vitamin hipovitaminosis)) and DNA hydroximethylation was investigated. Hydroxymethylation measurement was done using a gold standard technique (liquid chromatography + mass spectrometry), the biological age equivalent was calculated by LC-MS in laboratories Reunis, to verify the potential value of DNA methylation as a CVD biomarker.

Results
Generally, 296 both gender patients were analyzed regarding metabolic syndrome and oxidative stress, age group 40-50 years (Me=47,1). MethylAge (DNA-hydroxymethylation) in analyzed group has average age 40,1 years old. DNA Hydroxymethylation is higher in those individuals, who has increased waist circumference, as well as, statistically significant correlation was observed between MethylAge waist circumference, metabolic syndrome and hypertriglyceridemia (p&lt;0,05).

Conclusion
The evidence that the age-related changes in DNA methylation play a role in aging comes from studies of anti-aging interventions (e.g., caloric restriction, iron deficiency, dyslipidemia). Our data showed a link between premature biological ageing and waist circumference, hypertrigliceridimia. Hydroxymethylation of DNA is a good epigenetic marker for aging and risk assessment, especially in alliance with AGEs and oxidative stress research.