bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vanglfacilitates mesenchymal thinning during lung sacculation independently ofCelsr
Authors: Paramore Sarah V. , Trenado-Yuste Carolina , Sharan Rishabh , Devenport Danelle , Nelson Celeste M. 
Published: December 2022

SummaryThe planar cell polarity (PCP) complex orients cytoskeletal and multicellular organization throughout vertebrate development. PCP is speculated to function in formation of the murine lung, where branching morphogenesis generates a complex tree of tubular epithelia whose distal tips expand dramatically during sacculation in preparation for gas exchange after birth. Here, using tissue-specific knockouts, we show that the PCP complex is dispensable in the airway epithelium for sacculation. Rather, we find a novel,Celsr1-independent role for the PCP componentVanglin the pulmonary mesenchyme: loss ofVangl1/2inhibits mesenchymal thinning and expansion of the saccular epithelium. Further, loss of mesenchymalWnt5amimics the sacculation defects observed inVangl2-mutant lungs, implicating mesenchymal Wnt5a/Vangl signaling as a key regulator of late lung morphogenesis. By mathematically modeling sacculation, we predict that the process of sacculation requires a fluid mesenchymal compartment. Finally, lineage-tracing and cell-shape analyses are consistent with the pulmonary mesenchyme acting as a fluid tissue, and suggest that loss ofVangl1/2likely impacts the ability of mesenchymal cells to exchange neighbors. Our data thus uncover an explicit function forVangland the pulmonary mesenchyme during late lung morphogenesis to actively shape the saccular epithelium.
MOOC-based learning for human resource development in organizations during the post-pandemic and war crisis: a study from a developing country perspective
Authors: Shahriar Shamsul Huq Bin , Akter Silvia , Sultana Nayeema , Arafat Sayed , Khan Md. Mahfuzur Rahman 
Published: December 2022

PurposeHuman resources (HR) management has encountered unforeseen obstacles and issues in recruiting, retaining, training and developing workforces under the “new normal” due to pandemic circumstances followed by the Russo–Ukrainian War and global economic turmoil. As the world is now well-equipped with technological advancements and internet-based connectivity, many pandemic disruptions have been avoided through rapid adaptation of technological systems. Despite the constructive outcomes of this contemporary approach to learning and development (L&D), this study explores the further depths of massive open online courses (MOOC) platform adoption in human resource development initiatives during pandemic times.Design/methodology/approachA qualitative research approach was adopted to understand the employee and HR perspective on the changes in L&D approaches in organizations. To gather the primary data, respondents were divided into two clusters; different sets of questionnaires were developed for interview sessions.FindingsResults suggest that employee L&D was much more improvised with distance or online learning, including organizational e-learning systems and MOOC platforms. To accomplish their HR development goals, organizations went through significant transformations during the Coronavirus pandemic; organizational attempts to initiate online training and MOOC-based learning fostered positive results in employee capacity development, process improvement, employee engagement and motivation.Originality/valueThis research will assist organizations in developing interactive training methods as an effective replacement for traditional training. Additionally, it will assist readers, practitioners and HR specialists in understanding how MOOCs are changing the L&D ecosystem.
The long tail of COVID and the tale of long COVID: Diagnostic construction and the management of ignorance
Authors: Barker Kristin Kay , Whooley Owen , Madden Erin F. , Ahrend Emily E. , Greene R. Neil 
Published: December 2022

AbstractWe bring together insights from the sociology of diagnosis and the sociology of ignorance to examine the early diagnostic unfolding of ‘Long COVID’ (LC). Originally described by patient activists, researchers set out to ponder its unwieldy clinical boundaries. Using a scoping review method in tandem with qualitative content analytic techniques, we analyse medicine’s initial struggles to construct a LC diagnosis. Paying attention to the dynamics of ignorance, we highlight three consequential conceptual manoeuvres in the early classifications of LC: causal agnosticism concerning the relationship between COVID‐19 and LC, evasion of lumping LC with similar conditions; and the predictable splitting off of medically explainable cases from the LC designation. These manoeuvres are not maleficent, inept or unreasonable. They are practical but impactful responses to the classificatory dilemmas present in the construction of diagnoses amidst ignorance. Although there are unique aspects to LC, we suggest that its early fate is nevertheless emblematic of medicine’s diagnostic standardisation processes more generally. To varying degrees, diagnoses are ignorance management strategies; they create a pathway through the uncertainty at the core of disease realities. However, while diagnoses circumscribe some types of ignorance, they produce others through the creation of blind spots and paths not taken.
When left hands touch: shadow vows and Jung’s quaternity
Authors: Nelson Elizabeth Éowyn , Delmedico Anthony 
Published: December 2022

AbstractIs there a connection between the exchange of vows and the fighting and suffering of couples that are unique to the institution of marriage? This essay introduces the concept of Shadow Vows, the unacknowledged assumptions, agreements, and obligations each partner brings to the relationship, which the authors believe are often responsible for longstanding marital discord and strife. The authors ground the existence of shadow vows in Jung’s quaternity, alchemy, typology, archetypal theory, and depth approaches to couple therapy. The essay concludes with a list of themes indicative of shadow vow enactments in clinical work with couples.
Preparation and characterization of glucoamylase microcapsules prepared by W/O/W type complex coacervation freeze drying
Authors: Zong Xuyan , Li Huan , Tang Qian , Wang Xiangyu , Li Yuanyi , Li Li 
Published: December 2022

AbstractGlucoamylase was often used in the brewing industry but was unstable to several environmental factors and reacted quickly to produce fermentable sugar, which limited its applications. Microencapsulation could effectively overcome the drawbacks. This study evaluated the feasibility of the preparation of glucoamylase microcapsules (GM) using W/O/W complex coacervation‐freeze‐drying method. The parameters of the microcapsules were optimized by the response surface optimization design: core‐wall ratio at 1:1, wall‐material concentration at 8%, and coagulation time for 20 min. Under current condition, the final microencapsulation efficiency reached 85.64 ± 1.60%. Glucoamylase could be slowly released for more than 96 h in the liquid state, and could react slowly for more than 336 h in the solid state. The optimized GM were incubated for 1 h, and the relative enzyme activity was better than that of free glucoamylase under high temperature conditions. The water capacity, solubility, morphology, differential scanning calorimetry, and Fourier transform infrared spectroscopy were conducted. Glucoamylase exhibited good sustained release characteristics. The microcapsules were more resistant to environmental stimuli and showed stronger robustness after optimization.Practical ApplicationSaccharification enzymes are often used in the winemaking industry, and direct addition will cause the fermentation process to heat up too quickly, resulting in the inactivation of microorganisms and saccharification enzymes, affecting the efficiency of saccharification enzymes. Therefore, microcapsules are used to encapsulate the saccharification enzyme, and its efficacy is slowly released for a long time during the fermentation process.
Who pays attention to sustainability reports and why? Evidence from Google search activity
Authors: Ferguson Patrick J. , Hronsky Jane , Pinnuck Matt 
Published: December 2022

AbstractWe introduce country‐level Google search activity as a direct measure of the level of stakeholder attention directed towards sustainability reports. We validate this measure by establishing that search activity for sustainability reports is correlated with temporal patterns in firms' supply of these reports. To frame the economic magnitude of this search behaviour, we then show that the level of attention directed towards sustainability reports is very low compared to the level of attention directed towards financial and accounting information. Next, we examine two related research questions. First, we identify who pays attention to sustainability reports. We find, consistent with the environmental Kuznets curve, that attention towards sustainability reports is strongly associated with economic development. Consistent with findings in prior research that suggest citizens in stakeholder‐oriented countries have stronger preferences for firms to act prosocially, we also find that search activity for sustainability reports relative to search activity for financial performance metrics is greater in civil law countries than in common law countries. Finally, we then explore the question of why individuals pay attention to sustainability reports and find evidence that suggests sustainability reports are used for two primary purposes: evaluating the societal impacts of firms' actions; and, firm valuation.
Becoming Digitally Resilient: Understanding the Gap between Online Government Services and Low Ability Users
Authors: LEFEVRE YONI , GAZY DOROTA 
Published: December 2022

In the Netherlands, approximately 2.5M people struggle to use technology in their daily life and are unable to use online governmental services independently. People with low digital literacy are increasingly feeling left behind by the digitalisation of society. Even though this group is very diverse, what they have in common is getting stuck at some point when they are in a digital environment e.g. when filling in digital forms.The Dutch government wants to provide more effective and appropriate help by designing more accessible online services and offering different types of support. To support this, STBY was commissioned to do qualitative research to better understand the experiences of people with limited digital skills. The ethnographic methods used in the project enabled the researchers to get a holistic understanding of participants' experiences of going through this emotional and difficult journey. This personal approach enabled participants to share the ‘obstacles’ they are confronted with when using digital devices.Currently, most people with limited digital skills find their own ways of navigating through digital services because they have this intrinsic motivation to function as individuals in society. This research went beyond investigating what a better digital service could look like but it also explores how people might be given appropriate tools and opportunities to be resilient in their own space, and at their own pace, both online and offline. Our research recommended strengthening a network of support that offers more inclusive and diverse help for people with different needs and levels of digital experiences.
Migration governance evolution amidst a nested crisis: The case of South America
Authors: Margheritis Ana 
Published: December 2022

AbstractThis article aims to expand our understanding of how diverse crises affect the evolution of migration governance. Building upon an interdisciplinary framework, it proposes a nuanced notion of migration crisis, qualified as ‘nested’, and illustrates its application through an interpretative synthesis of empirical works and primary sources on responses to the massive emigration of Venezuelans to South American countries at the peak of the outflow (2017–2019). This conceptual and analytical exercise highlights the interplay of national and regional dynamics and fills some gaps in existing accounts regarding what governability entails, and the nature, scope, and reasons of governance evolution. It shows that policy choices were embedded in and shaped by several critical structural conditions and junctures; disagreement on problem definition precluded cooperation and redefined both the role of key actors and the construction of the crisis narrative; apparent contradictions between rhetoric and practice were rather a re‐framing of complementary (humanitarian/securitization) interventions.
Description of COVID‐19 patients and mapping nursing data to ICNP 2021 reference set in SNOMED CT
Authors: Thoroddsen Asta , Rúnarsdóttir Elva Rún , Örlygsdóttir Brynja 
Published: December 2022

AbstractAimTo describe nursing care of COVID‐19 patients with International Classification for Nursing Practice (ICNP) 2019, ICNP 2021 reference set, and Systematized Nomenclature of Medicine–Clinical Terms (SNOMED CT).BackgroundFrom the beginning of the COVID‐19 pandemic, nurses have realised the importance of documenting nursing care.IntroductionIt is important to recognise how real nursing data match the ICNP reference set in SNOMED CT as that is the terminology to be used in Iceland.MethodsA descriptive study with two methods: (a) statistical analysis of demographic and coded clinical data identified and retrieved from Electronic Health Record (EHR) and (b) mapping of documented nursing diagnoses and interventions in EHRs into ICNP 2019, ICNP 2021 and SNOMED CT 2021.ResultsThe sample consisted of all (n = 91) adult COVID‐19 patients admitted to the National University Hospital between 28 February and 30 June 2020. Nurses used 62 different diagnoses and 79 interventions to document nursing care. Diagnoses and interventions were best represented by SNOMED CT (85.4%; 100%), then by ICNP 2019 version (79.2%; 85%) and least by the ICNP 2021 reference set (70.8; 83.3%). Ten nursing diagnoses did not have a match in the ICNP 2021 reference set.DiscussionNurses need to keep up with the development of ICNP and submit to ICN new terms and concepts deemed necessary for nursing practice for inclusion in ICNP and SNOMED CT.ConclusionNot all concepts in ICNP 2019 for COVID‐19 patients were found to have equivalence in ICNP 2021. SNOMED CT–preferred terms cover the description of COVID‐19 patients better than the ICNP 2021 reference set in SNOMED CT.Implications for nursing and health policyThrough the use of ICNP, nurses can articulate the unique contribution made by the profession and make visible the specific role of nursing worldwide.
Preparing for the upcoming 2022/23 influenza season: A modelling study of the susceptible population in Australia, France, Germany, Italy, Spain and the United Kingdom
Authors: Boudewijns Bronke , Paget John , Del Riccio Marco , Coudeville Laurent , Crépey Pascal 
Published: December 2022

AbstractWe analysed the influenza epidemic that occurred in Australia during the 2022 winter using an age‐structured dynamic transmission model, which accounts for past epidemics to estimate the population susceptibility to an influenza infection. We applied the same model to five European countries. Our analysis suggests Europe might experience an early and moderately large influenza epidemic. Also, differences may arise between countries, with Germany and Spain experiencing larger epidemics, than France, Italy and the United Kingdom, especially in children.
Asymmetric review of qualified immunity appeals
Authors: Reinert Alexander A. 
Published: December 2022

AbstractThis article presents results from the most comprehensive study to date of the resolution of qualified immunity in the federal courts of appeals and the US Supreme Court. By analyzing more than 4000 appellate decisions issued between 2004 and 2015, this study provides novel insights into how courts of appeals resolve arguments for qualified immunity. Moreover, by conducting an unprecedented analysis of certiorari practice, this study reveals how the US Supreme Court has exercised its discretionary jurisdiction in the area of qualified immunity. The data presented here have significant implications for civil rights enforcement and the uniformity of federal law. They show that qualified immunity, when deployed, often bars relief for plaintiffs. Moreover, they show that courts of appeals reverse decisions to deny qualified immunity far more often than they reverse decisions to grant qualified immunity, and that this asymmetric review is correlated with traditional indicators of judicial ideology, among other variables. Significantly, the data also suggest that the asymmetric review that characterizes appellate decisions is also present in the Supreme Court's certiorari practice.
Truth and reparations: A perpetual challenge for the marginalized in Peru
Authors: Kellett Nicole Coffey 
Published: December 2022

AbstractThe Peruvian Truth and Reconciliation Commission (Comisión de la Verdad; CVR) is considered one of the most comprehensive in Latin America. Peru set forth a plan for reparations to address the gross inequalities underlying the war, yet nearly twenty years since the CVR report was submitted, extreme discrimination of victims undergirds the systemic challenges that impede the allocation of due resources and recognition of rights for war survivors. This article draws from a larger case study with a female war survivor from the Department of Ayacucho. By highlighting the challenges survivors face in accessing reparations, this research illustrates how a lack of judicial accountability, scarcity of resources applied to reparations, politicized narrative surrounding victimhood, and failure to adequately reconcile with the past, exacerbates marginalization that prompted the war and undermines the CVR's goal of transitional justice.
Clinical feasibility of absorbable gelatin film adhesion barrier (GM142 “TENALEAF®”) in gynecological laparoscopic surgery: Safety assessment for first‐in‐human use and surgical video
Authors: Kikuchi Iwaho , Momoeda Mikio , Ujihira Takafumi , Iguchi Michiyo , Koga Kaori , Morita Mineto 
Published: December 2022

AbstractAimTo evaluate the safety and operability of the GM142 (TENALEAF®, Medical Division, Gunze Limited, Tokyo, Japan) adhesion barrier applied in patients undergoing surgery for benign gynecologic disease.MethodsThis multicenter open study enrolled 34 patients from November 2018 to October 2019.ResultsThe primary outcome was the incidence of adverse events (AE) within 12 weeks postoperatively. None of the 30 patients completing the study experienced a life‐threatening AE. Thirteen patients (43.3%) suffered 30 mild or moderate AE in total. No intestinal obstruction (0/30) was observed, with the sample size justified by the AdSpray® trial (8/61 patients with AE). No gelatin‐specific Immunoglobulin E (IgE) antibodies were induced in the patients. The adhesion barrier could be easily inserted (even via trocar) and positioned. After malfunctions were reported in six patients, the instructions for use were updated for trocar use.ConclusionThis study showed the safety and clinical feasibility GM142 as an adhesion barrier.
Mitochondrial genome phylogeny reveals the deep‐time origin of Gomphomastacinae (Orthoptera: Eumastacidae) and its alpine genera in China
Authors: Ge Jun‐Jie , Ying Hong‐Fei , Xu Sheng‐Quan , Huang Hua‐Teng 
Published: December 2022

AbstractGomphomastacinae is a grasshopper subfamily in Eumastacidae, with a morphology and distribution distinct from other subfamilies. The alpine genera of Gomphomastacinae that inhabit the Qinghai–Tibet Plateau in China show unique characteristics adapted to high‐altitude life. However, their phylogenetic position and biogeographic history remain controversial. Thus, to determine the diversification history of these alpine genera and the origin of the subfamily, we obtained mitochondrial genome sequences from all seven Gomphomastacinae genera distributed in China. The reconstructed phylogeny was well supported and confirmed the phylogenetic position of Gomphomastacinae within Eumastacidae. Time calibration revealed a deep‐time origin of the subfamily dating back to the Cretaceous period, and the diversification among alpine genera was also an ancient pre‐Miocene event (30–50 Ma). Based on phylogeny and time estimates, the most likely biogeographic scenario is that Gomphomastacinae originated from an ancestral lineage that lived in East Gondwana and dispersed to Central and Western Asia through India. Subsequently, the alpine genera likely diverged along with the uplift of the Qinghai–Tibet Plateau and survived drastic climate change by in situ adaptation to high‐altitude dwellings.
Phosphorylation chemistry of the Bordetella PlrSR TCS and its contribution to bacterial persistence in the lower respiratory tract
Authors: Barr Sarah A. , Kennedy Emily N. , McKay Liliana S. , Johnson Richard M. , Ohr Ryan J. , Cotter Peggy A. , Bourret Robert B. 
Published: December 2022

AbstractBordetella species cause lower respiratory tract infections in mammals. B. pertussis and B. bronchiseptica are the causative agents of whooping cough and kennel cough, respectively. The current acellular vaccine for B. pertussis protects against disease but does not prevent transmission or colonization. Cases of pertussis are on the rise even in areas of high vaccination. The PlrSR two‐component system, is required for persistence in the mouse lung. A partial plrS deletion strain and a plrS H521Q strain cannot survive past 3 days in the lung, suggesting PlrSR works in a phosphorylation‐dependent mechanism. We characterized the biochemistry of B. bronchiseptica PlrSR and found that both proteins function as a canonical two‐component system. His521 was essential and Glu522 was critical for PlrS autophosphorylation. Asn525 was essential for phosphatase activity. The PAS domain was critical for both PlrS autophosphorylation and phosphatase activities. PlrS could both phosphotransfer to and exert phosphatase activity toward PlrR. Unexpectedly, PlrR formed a tetramer when unphosphorylated and a dimer upon phosphorylation. Finally, we demonstrated the importance of PlrS phosphatase activity for persistence within the murine lung. By characterizing PlrSR we hope to guide future in vivo investigation for development of new vaccines and therapeutics.