bluuebunny/crossref_metadata_2025_split huggingface dataset:
Plant Derived MicroRNA156: A Critical Regulator of Environmental Stress
Authors: Upadhyay Anam , Singhal Shivani , Bhardwaj Bhavya , Rani Vibha 
Published: April 2023

Abstract
Rice is the primary consumable crop of much of the Indian population. The use of hexavalent chromium (Cr IV) in various manufacturing industries has led to the contamination of the fields via effluents released in the water sources. MicroRNAs, crucial for various cellular processes, have been successfully detected in many plants with the prelude of Next Generation Sequencing (NGS). The objective of the presented study was to investigate the role of miRNAs as critical regulators of chromium toxicity in rice IR-64 species. Bioinformatic approaches were used to characterize the NGS data of root samples of Oryza sativa indica Cr (VI) toxicity. It was determined that metal stress in the rice sample modulated the regulation of several miRNAs but miR156 was found to be a crucial modulator in our study and was further characterized to expand on the recently developed idea of cross-kingdom relationships. Different assays were performed on H9C2 cardiomyocytes to examine the effect of chromium on the heart tissues since the accumulation of heavy metals in the human systems from diet has been established. Our research also indicated a substantial correlation between the physiological processes of growth and development under chromium stress and miRNA-targeted genes. Therefore, these results could serve as a foundation for future investigation into how miRNAs regulate biological processes.
Cemeteries as a source of environmental contamination: phytogenotoxicity of the biogenic amines cadaverine and putrescine
Authors: Braga Ana Paula Andrade , de Souza Letícia Rosa , Lima Maria Gabriela Franco , Gonçalves Matheus de Moraes Cunha , Marin-Morales Maria Aparecida 
Published: April 2023

Abstract
Among the compounds present in necro-leachate, a liquid released during the process of decomposition of the human body, are the biogenic amines cadaverine and putrescine. Although some studies on necro-leachate have indicated a potential ecotoxicological and public health risk associated with it, the research on this type of contamination is still rather limited. This study presents information about the phytotoxic and cytogenotoxic potential of cadaverine and putrescine, evaluated separately and within a mixture. Phytotoxicity was evaluated through a germination test, the initial growth of seedlings with Lactuca sativa, and cytogenotoxicity through chromosomal aberration and micronucleus tests with Allium cepa. The L. sativa results showed a phytotoxic effect for the evaluated amines, by reducing root (>90%) and hypocotyl (>80%) elongation. The co-exposure of cadaverine and putrescine potentiated cytogenotoxic activity by aneugenic action in the meristematic cells of A. cepa. From this result, it is possible to infer the eco-toxicogenic potential of cadaverine and putrescine amines and to emphasize the importance of further research in order to assess the risks of contamination generated in cemetery environments.
Computational Insights on the Impact of Allotypic Variation and Dimerization on Erap1 and Erap2 Structures Running Title: Structural Analysis of Erap1 and Erap2 Allotype Dimers
Authors: Dilek Yunus Emre , Kara İrem , Kıvrak Sena , Özkaya Şeyma Çolakoğlu , Erzik Can , Abacar Kerem Yiğit , Atagündüz Mehmet Pamir , Akcapinar Gunseli Bayram 
Published: April 2023

Abstract
Ankylosing Spondylitis is an autoimmune disease leading to inflammation in the joints and ligaments of the spine. ERAP1 is a major risk factor for AS and ERAP1 mutations may result in structural changes that alter the trimming efficiency, thereby altering the immune response. The underlying structural mechanisms of AS pathogenesis have not yet been fully elucidated. This study investigated ERAP1/ERAP2 allotypes using Molecular Dynamics in both monomeric and dimeric forms. ERAP1's domain IV has been found to be a favorable region for dimerization. Different allotype dimers exhibited different stability characteristics. Furthermore, the effects of allotypic variation were more pronounced in Hap2-/Hap8-coupled dimer structures and were more distinct in heterodimers. An analysis of the interchain region revealed that both H-bonding and electrostatic interactions between chains of Hap2–N392 heterodimer structures were lower than those between Hap2–Hap2 revealing that allotypic variations played a significant role in stabilizing and destabilizing dimer structures.
‎dimension of non-summand submodules
Authors: Alehafttan Alireza 
Published: April 2023

Abstract

‎We introduce and study the concept of essential Krull dimension as dual of small Krull dimension of a module‎, ‎which are defined in the same vein as Krull dimension of a module‎. ‎In particular‎, ‎we aim to show that there are some natural relations between the essential Krull dimension and the Krull dimension of an arbitrary module A‎. ‎We prove that if a module has finite Goldie dimension‎, ‎then it has Krull dimension if‎, ‎and only if‎, ‎it has essential Krull dimension and show that A/Soc(A) ‎‎has Krull dimension if‎, ‎and only if‎, ‎A has essential Krull dimension‎. ‎We introduce and study the concepts of non-summand Krull dimension of an R-module over an arbitrary associative ring R as a generalization of essential Krull dimension and small Krull dimension and we prove that an R-module has non-summand Krull dimension if‎, ‎and only if‎, ‎it has Krull dimension or is semisimple‎.
Arthroscopic treatment of bursal-sided rotator cuff tears using knotted and knotless single-suture bridge techniques: a retrospective cohort study
Authors: Hu Yangyang , Lu Yaojia , Wang Zhanye , Park Jin-Yong , fei Wen , Yang Yuxia , Zhang Yucheng , Gao Rangshan 
Published: April 2023

Abstract
Purpose To compare clinical outcomes of knotted and knotless single-suture bridge techniques in the arthroscopic treatment of bursal-sided rotator cuff tears.Methods Patients with bursal-sided tears were analyzed from June 2017 to March 2019; 54 patients were repaired using the knotted single-suture bridge technique (KT group), 59 patients with the knotless single-suture bridge technique (KLT group). All patients were followed up for a minimum of 24 months (in the range 24–35 months). The shoulder range of motion, and visual analog scale (VAS) score data were collected before operation, at three weeks, at three and six months after operation, and at the last follow-up. Meanwhile, American Shoulder and Elbow Surgeons (ASES) score and Constant–Murley (CS) shoulder score were collected before operation and at the last follow-up. Rotator cuff healing was evaluated by Barth ultrasonic classification at the last follow-up.Results At the last follow-up, VAS score had decreased from 5.0 (3.8, 6.0) to 0.0 (0.0, 1.0) in the KT group and from 5.0 (4.0, 6.0) to 0.0 (0.0, 0.0) in the KLT group. VAS score was higher in the KT group than in the KLT group at four postoperative time points. At three and six months after surgery, the patients in the KLT group had better anterior flexion and internal rotation than the KT group. Meanwhile, at the last follow-up, the internal rotation in the KLT group was still better than that of the KT group (P = 0.023), and the postoperative ASES score in the KLT group(97.90 ± 1.84) was significantly higher than that in the KT group(94.10 ± 3.18) (P = 0.001). Finally, there were two cases of retear in the KT group, and one case of retear in the KLT group, with no statistically significant difference (P = 0.938). At the final follow-up, healing was better in the KLT group by Barth ultrasonic classification (P = 0.019).Conclusions The knotless single-suture bridge technique maybe can result in more obvious pain relief, better anterior flexion and internal rotation range of motion, and functional recovery of the shoulder joint in the early stages. Also, healing may be better under ultrasound classification with the knotless single-suture bridge technique.Level of evidence: Level III; Retrospective Cohort Study; Treatment Study
On logarithmically superquadratic functions
Authors: Krnic Mario , Moradi Hamid Reza , Sababheh Mohammad 
Published: April 2023

Abstract
In this paper, we develop a concept of a logarithmically super\-qua\-dratic function. Such a class of functions is defined via superquadratic functions.These functions possess some superior properties, especially if they take values greater than or equal to one. We prove that they are convex and superadditive in the latter case.In particular, we also obtain the corresponding refinement of the Jensen inequality in a product form. Furthermore, we derive an external form of the Jenseninequality and the corresponding reverse. Finally, we give a variant of the Jensen operator inequality for logarithmically superquadratic functions.All established results are derived via the corresponding relations for superquadratic functions.
Hyperopic shift following corneal graft rejection in a patient with keratoconus: A case report
Authors: Cheng Ya-Feng , Liu Chun-Fu , Meir Yaa-Jyuhn James , Hsiao Ching-Hsi , Ma David Hui-Kang , Chen Hung-Chi 
Published: April 2023

Abstract
Background Penetrating keratoplasty (PK) is the dominant technique for visual restoration of corneal blindness worldwide. Corneal graft rejection and refractive errors are common postoperative issues of it, but correlation between these complications was seldom reported. To the author’s knowledge, this is the first reported case describing hyperopic change following post-penetrating keratoplasty graft rejection.Case presentation A 15-year-old female undergoing PK for advanced keratoconus in the left eye. Postoperatively, the graft was clear and her corrected distance visual acuity (CDVA) improved to 20/20. Corneal topography revealed anterior chamber depth (ACD) of 5.87 mm and keratometry readings of 42.4/46.1 diopters (D). However, decreasing visual acuity to counting fingers was noted after twelve months. Slit-lamp biomicroscopic examination showed stromal edema and mutton-fat keratic precipitates infiltration. Corneal graft rejection was diagnosed and CDVA resumed to 20/20 within one month after intensive topical and high-dose systemic steroid administration. Four years later, corneal topography revealed an ACD of 2.98 mm and keratometry readings of 42.4/45.1 D with spherical equivalence of + 1.25 D. Clinically and topographically, the corneal graft demonstrated a process of flattening before and after the episode of graft rejection.Conclusions Graft rejection may cause hyperopic shift in patients with keratoconus after PK.
Increased use of antidiabetic drugs does not necessarily increase blood sugar control for T2DM ： cross-sectional analysis from the rural-urban fringe zone of Suzhou city, Jiangsu Province
Authors: Han Xingfa , Xue Peng , Yang Jingyu , Wang Liping , Li Zheng , Wei Maoti , Ma Zhimin 
Published: April 2023

Abstract
Objective:
In order to control blood glucose levels, anti-glycemic drugs are used in T2DM patients. However, with more drugs are approved and widely clinical used, it is important to explore the association between the number of hypoglycemic drugs usage and T2DM control.
Methods:
From August 2018 to January 2021, three health service centers (urban-rural fringe zone) participated in T2DM health management project offering basic public health service from hospitals in Suzhou, Jiangsu province. Glycated hemoglobin (HbA1c) and fasting plasma glucose (FPG) level, combined with detail information of the diabetic history and hypoglycemic drugs usage were collected during the carryout of the project. Basic information and clinical laboratory examinations were analyzed with Student’ t or t’ or chi-square test for univariate analysis. Multivariate analyses were used for exploring multiple variables.
Results:
The level of glycosylated hemoglobin (HbA1c) less than 7.0% were consider as well-controlled of T2DM and the control rate of the patients was 36.8% (434 / 1179, 95% CI 33.2% - 38.8%). Sulfonylureas, biguanides, glucosidase inhibitors and insulin were the most frequently used hypoglycemic drugs in T2DM patients in this region and the utilization rates of them were 65.5%, 66.4%, 17.7% and 19.1% in the uncontrolled patients and in controlled were 68.4%, 58.5%, 14.3% and 11.1%, respectively. Higher proportion of biguanides, glycosidase inhibitors and insulin in the uncontrolled patients were observed than that in the controlled (P <0.05). The proportions for one, two, or more than three hypoglycemic drugs used in the uncontrolled patients were 29.5%, 51.7% and 18.8%, in the controlled group was 45.6%, 46.1% and 8.2%, respectively. On the whole, the number of drugs used in the uncontrolled patients was higher than that in the controlled group (P <0.001). Factors including the course of diabetes, biguanides, glucosidase inhibitors, and insulin usage were associated with poor glycemic control according to multivariate regression analysis.
Conclusions:
Anti-glycemic drugs play important role in lowering blood glucose for T2DM patients, but more drugs (more numbers or larger dosage ) might not improve blood glucose control. Especially, for management of diabetic patients in the rural-urban fringe zone, related factors should pay more attention other than hypoglycemic drugs.
Universal Chemical Programming Language for Robotic Synthesis Reproducibility
Authors: Hein Jason , Rauschen Robert , Guy Mason , Cronin Leroy 
Published: April 2023

Abstract
The amount of chemical synthesis literature is growing quickly, but it still takes a long time to share and evaluate new processes because of cultural and practical barriers. Herein, we present an approach that uses a universal chemical programming language (χDL) to encode and execute synthesis procedures for a variety of chemical reactions including reductive amination, ring formation, esterification, carbon-carbon bond formation, and amide coupling on different hardware and in different laboratories. With around fifty lines of code per reaction, our approach uses abstraction to efficiently compress chemical protocols. Our different robotic platforms consistently produce the expected synthesis with yields up to 90% per step, matching those achieved by an expert chemist. This allows for faster and more secure research workflows and can be used to increase the throughput of a process by number-up instead of scale-up. To achieve that we use Chemputer-type platforms at the University of Glasgow and the University of British Columbia, Vancouver as well as Opentrons- and multi-axis cobotic robots to distribute and reproduce experimental results. In total, protocols for 7 complex molecules were validated and disseminated to be reproduced in two international laboratories and on three independent robots.
Identification and validation of a prognostic risk score model for lung adenocarcinoma constructed based on immunogenic cell death
Authors: xie guijuan , Xu Yiming , Bao Liang , He Ting , Ren Xian , Ji JiaLi , Meng XinMin , Zhao Bo , Wang Xun 
Published: April 2023

Abstract
Background Immunogenic cell death (ICD) has been classified as a form of regulated cell death (RCD) sufficient to activate adaptive immune responses, which may contribute to the immunotherapy. The identification of ICD-related biomarkers stratifying lung adenocarcinoma patients according to their benefit from ICD immunotherapy would be of great advantage.Methods We identified two ICD-related subtypes by consensus clustering. Univariate and multivariate Cox proportional risk analyses were used to identify prognostic risk models with prognostic value. Kaplan-Meier analysis, univariate and multivariate Cox regression analysis, and subject work characteristic (ROC) curve analysis were used to validate the risk models.Results High ICD subtypes are associated with favorable clinical outcomes, abundant immune cell infiltration, and highly active immune response signaling. We developed and validated an ICD-related prognostic model that predicts survival of lung adenocarcinoma patients and correlates with the tumor immune microenvironment. In addition, predictive line graphs were created to further validate the risk model as a new independent prognostic factor for patients with lung adenocarcinoma.Conclusions we established a new classification system of LUAD based on ICD signatures. This stratification had significant clinical outcomes for estimating prognosis, as well as the immunotherapy of LUAD patients.
Combined Effects of Tropicamide Phenylephrine eyedrops on retinal microvasculature and choroidal thickness in myopic children
Authors: Zheng Min-Mig , Wang Tian-Tian , Dong Jing-hong , Li Chen-Hao , Cao Xiao , Wu Chang-Fan 
Published: April 2023

Abstract
Aims:To evaluate the effect of tropicamide phenylephrine(TP) eyedrops on the retinal and choroidal vascular density and choroidal thickness.
Methods: A prospective clinical study was used. 72 myopic children and adolescents aged 4-14 years old were given TP eyedrops to dilate the pupil, and all participants were given relevant ophthalmological examination before and after pupil dilation. OCTA is used to scan the macular 3*3mm area with layered lines. Image J software was used to measure the retinal and choroidal vascular density at each layer and OCT enhanced depth imaging mode was performed for the subfoveal choroidal thickness assessment.
Results: Following instillation of the TP eyedrops, the superficial retinal vascular density was decreased (from28.67±4.11 to 26.47±6.47, p<0.001) significantly, the choroidal vascular density increased (from37.04±6.83 to 37.81±6.20,p<0.001) in the macular area, and the choroidal thickness of subfoveal increased (from 243.94±65.10 to 248.59±69.11,p<0.001). Through multivariate analysis, age was the main factor that affects the superficial retinal and choroidal vascular density and choroidal thickness.
Conclusion: TP eyedrops can significantly reduce the superficial retinal vascular density and increase the choroidal vascular density and choroidal thickness in children. Age is the main factor that affects the superficial retinal and choroidal vascular density and choroidal thickness.
WITHDRAWN: Research on gas emission quantity prediction model based on EDA-IGA
Authors: Peng Ji , Shi shiliang , Shi Xingyu 
Published: April 2023

Abstract
In order to accurately predict the possible gas emission quantity in coal mines, it is proposed to use the multi-thread calculation of the Immune Genetic Algorithm (IGA) and injection of vaccines to improve the accuracy of prediction and combine the Estimation of Distribution Algorithm (EDA) to the distribution probability of excellent populations. Calculating, and selecting excellent populations for iteration, optimize the population generation process of the Immune Genetic Algorithm, so that the population quality is continuously optimized and improved, and the optimal solution is obtained, thereby establishing a gas emission quantity prediction model based on the Immune Genetic Algorithm and Estimation of Distribution Algorithm. Using the 9136 mining face with gas emission hazards in a coal mine from Shandong Province in China as the prediction object, the absolute gas emission quantity is used to scale the gas emission quantity, and it is found that the model can accurately predict the gas emission quantity, which is consistent with the on-site emission unanimous. In the prediction comparison with IGA, it is found that the accuracy of the prediction results has increased by 9.51%, and the number of iterations to achieve the required goal has been reduced by 67%, indicating that the EDA has a better role in optimizing the population update process such as genetic selection of the IGA. Comparing the prediction results of other models, it is found that the prediction accuracy of the EDA-IGA is 94.93%, which is the highest prediction accuracy, indicating that this prediction model can be used as a new method for the prediction of coal mine gas emission.
Magnetized metformin-functionalized carrageenan as a solid acid-base bifunctional nanocatalyst for the one-pot synthesis of dihydropyrano[2,3- c]pyrazoles
Authors: Heydari Forozan , Bakhtiarian Mohsen , Khodaei Mohammad Mehdi 
Published: April 2023

Abstract
In the current work we introduced a magnetic nanocatalyst with acidic-basic properties by coating Fe3O4 magnetic nanoparticles with kappa-carrageenan (Carr) and metformin (Met) moieties. The successful synthesis of Carr-Met-MNPs nanoparticles was verified by FT-IR, XRD, VSM, FESEM, EDX-mapping and TGA. The acidic-basic properties of Carr-Met-MNPs were studied by titration. The Carr-Met-MNPs nanoparticles demonstrated very good to excellent yields (88-94%) for the four-component domino synthesis of dihydropyrano [2, 3-c] pyrazoles via condensation of hydrazine hydrate, ethyl acetoacetate, malononitrile, and aromatic aldehydes in the aqueous ethanol as a benign solvent system. The synergistic effect of sulfonic acid and amino groups can justify the catalytic activity of Carr-Met-MNPs. Also, the catalyst can be magnetically recovered. Simplicity of catalyst synthesis, use of a benign solvent system, improved activity, and easy recoverability (up to 5 runs) is some of prominent advantages of the present catalyst system. The heterogeneity of Carr-Met-MNPs nanocomposites was also confirmed by a hot filtration test under optimum reaction conditions.
Synthesis, morphological, dielectric studies and ionic conductivity of a sodium cerium diphosphate compound
Authors: Hamrit Fareh , Chtourou Rabiaa , Taloub Djedid , Gharbi Imen , Oueslati Abderrazek 
Published: April 2023

Abstract
The NaCeP2O7 compound was successfully synthesized by a high-temperature reaction with the solid-state method. Analyzing the XRD pattern, of the studied compound, confirms the orthorhombic phase with the Pnma space group. The examination of SEM images reveals that the majority of grains are around 500 to 900 nm with a uniform distribution. As for the EDX analysis, all chemical elements were detected and found in their appropriate ratio. The curves of temperature-dependent imaginary modulus M" versus angular frequency reveal the presence of one peak at each temperature, proving that the dominant contribution is associated to the grains. The frequency dependence of the conductivity of alternating current is explained using Jonscher's law. The close values of the activation energies obtained from the jump frequency and extracted from the dielectric relaxation of the modulus spectra, as well from the continuous conductivity imply that the transport takes place by the Na+ ions hopping mechanism. The charge carrier concentration in the title compound has been evaluated and shown to be independent of temperature. The exponent s increases with the increase in temperature, this behavior proves that the non-overlapping small polaron tunneling (NSPT) is the appropriate conduction mechanism model.