bluuebunny/crossref_metadata_2025_split huggingface dataset:
To cut or not to cut? A prospective randomized controlled trial on short-term outcomes of the uncut Roux-en-Y reconstruction for gastric cancer
Authors: Xu Hao , Yang Li , Zhang Dian-Cai , Li Zheng , Li Qing-Ya , Wang Lin-Jun , Li Feng-Yuan , Wang Wei-Zhi , Xia Yi-Wen , Xu Ze-Kuan 
Published: May 2023

Abstract
Background
Roux-en-Y (R-Y) anastomoses have been widely used in distal gastrectomy, while the incidence of Roux stasis syndrome remains common. Uncut R-Y anastomosis maintains the neuromuscular continuity, thus avoiding the ectopic pacemaker of the Roux limb and reducing the occurrence of Roux stasis. However, retrospective studies of Uncut R-Y anastomosis remain scarce and randomized controlled trials have not been reported.

Methods
We conducted a randomized controlled trial to compare the surgical safety, nutritional status, and postoperative quality of life (QOL) between uncut and classic Roux-en-Y (R-Y) reconstruction patients. Patients with Stage I gastric cancer were randomly enrolled and underwent laparoscopic distal gastrectomy followed by uncut or classic R-Y reconstruction. Body mass index and blood test were used to evaluate the nutritional status. QOL was evaluated using European Organization for Research and Treatment of Cancer QOL Questionnaire (STO22) and laboratory examinations at postoperative month (POM) 3, 6, 9, and 12. Computed tomography scanning was used to evaluate the skeletal muscle index (SMI) at POM 6 and 12. Endoscopy was performed at POM 12.

Results
Operation time, blood loss, time to recovery, complication morbidities, and overall survival were similar between the two groups. Compared with the classic R-Y group, the uncut R-Y group displayed a significantly decreased QOL at POM 9, possibly due to loop recanalization, determined to be occupied 34.2% of the uncut R-Y group. Post-exclusion of recanalization, the QOL was still higher in the classic R-Y group than in the uncut R-Y group, despite their hemoglobin and total protein levels being better than those in the classic R-Y group. Preoperative pre-albumin level and impaired fasting glycemia significantly correlated with the postoperative recanalization.

Conclusion
We found no significant benefit of uncut over classic R-Y reconstruction which challenges the superiority of the uncut R-Y reconstruction.

Trial registration
ClinicalTrials.gov Identifier: NCT02644148.
The heterogeneity of Parkinson’s disease
Authors: Wüllner Ullrich , Borghammer Per , Choe Chi-un , Csoti Ilona , Falkenburger Björn , Gasser Thomas , Lingor Paul , Riederer Peter 
Published: May 2023

AbstractThe heterogeneity of Parkinson’s disease (PD), i.e. the various clinical phenotypes, pathological findings, genetic predispositions and probably also the various implicated pathophysiological pathways pose a major challenge for future research projects and therapeutic trail design. We outline several pathophysiological concepts, pathways and mechanisms, including the presumed roles of α-synuclein misfolding and aggregation, Lewy bodies, oxidative stress, iron and melanin, deficient autophagy processes, insulin and incretin signaling, T-cell autoimmunity, the gut–brain axis and the evidence that microbial (viral) agents may induce molecular hallmarks of neurodegeneration. The hypothesis is discussed, whether PD might indeed be triggered by exogenous (infectious) agents in susceptible individuals upon entry via the olfactory bulb (brain first) or the gut (body-first), which would support the idea that disease mechanisms may change over time. The unresolved heterogeneity of PD may have contributed to the failure of past clinical trials, which attempted to slow the course of PD. We thus conclude that PD patients need personalized therapeutic approaches tailored to specific phenomenological and etiologic subtypes of disease.
Assessing Energetic Pathways and Time Lags in Estuarine Food Webs
Authors: Sinnickson Dylan , Harris Holden E. , Chagaris David 
Published: May 2023

AbstractDetecting strong species interactions in food webs is often challenging due to difficulties related to adequate experimentation and the prevalence of generalist diets throughout nature. A promising new mathematical technique, empirical dynamic modeling (EDM), has demonstrated the potential to identify trophic interactions between populations by assessing time lags between associated time series. We attempted to analyze trophic linkages both within a subtropical estuary, as well as a simulated, theoretical ecosystem, to determine how energy moves through these systems. Additionally, we intended to evaluate the technique’s ability to detect biological relationships in ecosystems of different complexity. In both datasets, we were able to clearly identify strong consumer—resource interactions, which were generally related to bottom-up drivers. Overall, trophic connections at lower trophic levels were more easily detected than linkages higher in the food web. The ability of EDM to detect food web interactions appeared to be strongly influenced by the degree of observation error exhibited in the data. In the empirical dataset, several examples of bottom-up processes were clearly evident including effects of discharge, nutrients, and/or chlorophyll-aconcentrations on anchovies (Anchoaspp.), Gulf flounder (Paralichthys albiguttata), and red drum (Sciaenops ocellatus). We also observed instances where lengths of time lags decreased as trophic level distances between consumers and resources decreased (for example, Anchovies, Gulf flounder, young-of-the-year seatrout). This analysis demonstrates the promising application of EDM to detect energetic pathways in systems of varying complexity.
Views on Augmented Reality, Virtual Reality, and 3D Printing in Modern Medicine and Education: A Qualitative Exploration of Expert Opinion
Authors: Urlings Julie , de Jong Guido , Maal Thomas , Henssen Dylan 
Published: May 2023

Abstract
Although an increased usage and development of 3D technologies is observed in healthcare over the last decades, full integration of these technologies remains challenging. The goal of this project is to qualitatively explore challenges, pearls, and pitfalls of AR/VR/3D printing applications usage in the medical field of a university medical center. Two rounds of face-to-face interviews were conducted using a semi-structured protocol. First an explorative round was held, interviewing medical specialists (8), PhD students (7), 3D technology specialists (5), and university teachers (3). In the second round, twenty employees in high executive functions of relevant departments were interviewed on seven statements that resulted from the first interviewing round. Data analysis was performed using direct content analyses. The first interviewing round resulted in challenges and opportunities in 3D technology usage that were grouped in 5 themes: aims of using AR/VR/3D printing (1), data acquisition (2), data management plans (3), software packages and segmentation tools (4), and output data and reaching end-user (5). The second interviewing round resulted in an overview of ideas and insights on centralization of knowledge, improving implementation of 3D technology in daily healthcare, reimbursement of 3D technologies, recommendations for further studies, and requirement of using certified software. An overview of challenges and opportunities of 3D technologies in healthcare was provided. Well-designed studies on clinical effectiveness, implementation and cost-effectiveness are warranted for further implementation into the clinical setting.
A Network-DEA model to evaluate the impact of quality and access on hospital performance
Authors: Afonso G. P. , Ferreira D. C. , Figueira J. R. 
Published: May 2023

AbstractThe relationship between efficiency, quality, and access in healthcare is far from being well defined. In particular, there is no consensus on whether there is a trade-off between hospital performance and its social dimensions, such as the care appropriateness, safety, and access to proper health care. This study proposes a new approach based on the Network Data Envelopment Analysis (NDEA) to evaluate the existence of potential trade-offs between efficiency, quality, and access. The aim is to contribute for the heated debate around this topic with a novel approach. The suggested methodology combines a NDEA model with the weak disposability of outputs to handle with undesirable outputs related to the poor quality of care or the lack of access to appropriate and safe care. This combination results in a more realistic approach that has not yet been used to investigate this topic. We utilised data of the Portuguese National Health Service from 2016 to 2019, with four models and nineteen variables selected to quantify the efficiency, quality, and access to public hospital care in Portugal. A baseline efficiency score was calculated and compared with the performance scores obtained under two hypothetical scenarios to quantify the impact of each quality/access-related dimension on efficiency. The first scenario considers that each variable, individually, is at its best situation (for example, absence of septicaemia cases), and the second one, at its worst (e.g., all seen inpatients had a septicaemia case). The findings suggest that there might exist meaningful trade-offs between efficiency, quality, and access. Most variables exhibited a considerable and negative impact on the overall hospital efficiency. That is, we may expect a trade-off between efficiency and quality/access.
Climate science to inform adaptation policy: Heat waves over India in the 1.5°C and 2°C warmer worlds
Authors: T Arulalan , AchutaRao Krishna , Sagar Ambuj D 
Published: May 2023

AbstractDeveloping a better scientific understanding of anthropogenic climate change and climate variability, especially the prediction/projection of climate futures with useful temporal and geographical resolution and quantified uncertainties, and using that knowledge to inform adaptation planning and action will become crucially important in the coming years. Generating such policy-relevant knowledge may be particularly important for developing countries such as India. It is with this backdrop that, in this paper, we analyze future heat waves in India by using observations and a large number of model simulations of historical, + 1.5 °C, and + 2.0 °C warmer worlds. In both the future scenarios, there is an increased probability of heat waves during June and July when the Indian monsoon is in full swing and humidity is high, which makes the heat events even more of a health risk. While the highest temperatures in heat waves may not increase much in future climates, the duration and areal extent of the heat waves will most likely increase, leading to the emergence of new heat wave-prone zones in India. The results indicate that the joint frequencies of the longest duration and large area events could be nearly threefold greater in the + 1.5 °C and fivefold greater in the + 2.0 °C future scenarios compared to historical simulations. Thus, overall, the study indicates a substantial increase in the risk of heat events that typically elicit warnings from forecasters. The likely widespread and persistent nature of heat wave events in the future, as revealed by this study, will require planning and adaptation measures beyond the short-term disaster planning frameworks currently in place. Exploring what these measures might look like is beyond the scope of this study, but it underlines the importance of developing climate knowledge with high temporal and geographical resolution capable of informing adaptation policy and planning.
Sustainable and circularity in the decentralized hybrid solar-bioenergy system
Authors: Matheri Anthony Njuguna , Nabadda Esther , Mohamed Belaid 
Published: May 2023

AbstractThe sustainable development goals (SDGs) are fundamental to circular economy, climate action, sustainable digital environment initiatives that addresses the higher need of shifting towards fully sustainable and renewable energy systems. The decentralized power system has been applied and interconnected to the system and accounting to the renewable energy mix, energy storage and distribution. A decentralized hybrid renewable energy system can be of much help in providing a deficit of power between energy generation and demand where a single renewable energy system is not sustainable and reliable. The aim of this study was to characterize the biomass, perform the biomethane potential test of the biomass, select suitable bio-digester using multi-criteria decision analysis, carry out simulation-modelling of the solar-anaerobic digestion system in achieving energy self-efficiency with the development of the dynamic models that of climatic condition, social-economic and technology feasible. The performance of the system was designed and optimised to get maximum output power and mitigation of the environment at a lower cost. The performance was analysed based on present cost, locally availability, environmentally friendly, cost of energy on the local tariffs, load satisfaction, fuel consumption savings, operation and maintenance cost, human and technology capital and pollutants saving rates. The results showed major energy consummation from the solar-biodigester system, technology solutions that maximize energy efficiency and reduce the heat loss in the AD process. Waste to energy (WtE) technology coupled with the solar system could be viewed as key to sustainable, affordable and clean electricity generation.
What if She Earns More? Gender Norms, Income Inequality, and the Division of Housework
Authors: Magda Iga , Cukrowska-Torzewska Ewa , Palczyńska Marta 
Published: May 2023

AbstractWe examine the relationship between female contribution to household income and the division of housework between the partners, while accounting for their attitutes towards gender roles. We use data from the “Generation and Gender Survey” for Poland: a country where both employment rates of women and their involvement in housework are high, men and women work long hours, and labour market regulation and policies are unsupportive of work− family balance. We find that the female share of total household income is negatively related to women’s heavy involvement in housework. The direction of this relationship does not change when women earn more than their partners, so there is no support for the gender deviance neutralization hypothesis. We also find that individual gender norms matter for women’s involvement in unpaid work at home, and the uncovered link between the female share of household income and inequality between the partners in the division of housework. Women from less traditional households are more likely to share housework equally with their partners. Among couples with traditional gender attitudes, the female contribution to household income is not related to the division of housework. We conclude that narrowing gender pay gaps may be an important step towards more equality not only at work but also at home.
Well Posedness and Characterization of Solutions to Non Conservative Products in Non Homogeneous Fluid Dynamics Equations
Authors: Colombo Rinaldo M. , Guerra Graziano , Holle Yannick 
Published: May 2023

Abstract
Consider a balance law where the flux depends explicitly on the space variable. At jump discontinuities, modeling considerations may impose the defect in the conservation of some quantities, thus leading to non conservative products. Below, we deduce the evolution in the smooth case from the jump conditions at discontinuities. Moreover, the resulting framework enjoys well posedness and solutions are uniquely characterized. These results apply, for instance, to the flow of water in a canal with varying width and depth, as well as to the inviscid Euler equations in pipes with varying geometry.
Knockout of TRDMT1 methyltransferase affects DNA methylome in glioblastoma cells
Authors: Zabek Tomasz , Szmatola Tomasz , Adamczyk-Grochala Jagoda , Lewinska Anna , Wnuk Maciej 
Published: May 2023

Abstract
Purpose
We have previously shown that TRDMT1 methyltransferase is a regulator of chemotherapy-associated responses in glioblastoma cells. Despite the fact that glioblastoma, a common and malignant brain tumor, is widely characterized in terms of genetic and epigenetic markers, there are no data on TRDMT1-related changes in 5-methylcytosine pools in the genome. In the present study, the effect of TRDMT1 gene knockout (KO) on DNA methylome was analyzed.

Methods
CRISPR-based approach was used to obtain TRDMT1 KO glioblastoma cells. Total 5-methylcytosine levels in DNA, DNMT1 pools and DNMT activity were studied using ELISA. Reduced representation bisulfite sequencing (RRBS) was considered to comprehensively evaluate DNA methylome in glioblastoma cells with TRDMT1 KO.

Results
TRDMT1 KO cells were characterized by decreased levels of total 5-methylcytosine in DNA and DNMT1, and DNMT activity. RRBS-based methylome analysis revealed statistically significant differences in methylation-relevant DMS-linked genes in control cells compared to TRDMT1 KO cells. TRDMT1 KO-associated changes in DNA methylome may affect the activity of several processes and pathways such as telomere maintenance, cell cycle and longevity regulating pathway, proteostasis, DNA and RNA biology.

Conclusions
TRDMT1 may be suggested as a novel modulator of gene expression by changes in DNA methylome that may affect cancer cell fates during chemotherapy. We postulate that the levels and mutation status of TRDMT1 should be considered as a prognostic marker and carefully monitored during glioblastoma progression.
Translation of circHGF RNA encodes an HGF protein variant promoting glioblastoma growth through stimulation of c-MET
Authors: Saunders Jacquelyn T. , Kumar Sunil , Benavides-Serrato Angelica , Holmes Brent , Benavides Kennedy E. , Bashir Muhammad T. , Nishimura Robert N. , Gera Joseph 
Published: May 2023

Abstract
Introduction
HGF/c-MET signaling is a significant driver of glioblastoma (GBM) growth and disease progression. Unfortunately, c-MET targeted therapies have been found to be largely ineffective suggesting additional redundant mechanisms of c-MET activation.

Methods
Utilizing RNA-sequencing (RNA-seq) and ribosome profiling analyses of circular RNAs, circ-HGF (hsa_circ_0080914) was identified as markedly upregulated in primary GBM and found to potentially encode an HGF protein variant (C-HGF) 119 amino acids in length. This candidate HGF variant was characterized and evaluated for its ability to mediate c-MET activation and regulate PDX GBM cell growth, motility and invasive potential in vitro and tumor burden in intracranial xenografts in mice.

Results
An internal ribosome entry site (IRES) was identified within the circ-HGF RNA which mediated translation of the cross-junctional ORF encoding C-HGF and was observed to be highly expressed in GBM relative to normal brain tissue. C-HGF was also found to be secreted from GBM cells and concentrated cell culture supernatants or recombinant C-HGF activated known signaling cascades downstream of c-MET. C-HGF was shown to interact directly with the c-MET receptor resulting in its autophosphorylation and activation in PDX GBM lines. Knockdown of C-HGF resulted in suppression of c-MET signaling and marked inhibition of cell growth, motility and invasiveness, whereas overexpression of C-HGF displayed the opposite effects. Additionally, modulation of C-HGF expression regulated tumor growth in intracranial xenografted PDX GBM models.

Conclusions
These results reveal an alternative mechanism of c-MET activation via a circular RNA encoded HGF protein variant which is relevant in GBM biology. Targeting C-HGF may offer a promising approach for GBM clinical management.
The Casualties of War: An Excess Mortality Estimate of Lives Lost in the 2020 Nagorno-Karabakh Conflict
Authors: Karlinsky Ariel , Torrisi Orsola 
Published: May 2023

AbstractWho and how many died in the 2020 Karabakh War? With limited evidence provided by authorities, media outlets, and human rights organizations, still little is known about the death toll caused by the 44-day conflict in and around Nagorno-Karabakh. This paper provides a first assessment of the human cost of the war. Using age–sex vital registration data from Armenia, Azerbaijan, and the de facto Republic of Artsakh/Nagorno-Karabakh, we difference the 2020 observed mortality values from expected deaths based on trends in mortality between 2015 and 2019 to offer sensible estimates of excess mortality resulting from the conflict. We compare and contrast our findings with neighboring peaceful countries with similar mortality patterns and socio-cultural background and discuss them against the backdrop of the concurrent first wave of Covid-19. We estimate that the war led to almost 6,500 excess deaths among people aged 15–49. Nearly 2,800 excess losses occurred in Armenia, 3,400 in Azerbaijan, and 310 in de facto Artsakh. Deaths were highly concentrated among late adolescent and young adult males, suggesting that most excess mortality was directly related to combat. Beyond the human tragedy, for small countries like Armenia and Azerbaijan, such loss of young men represents a considerable long-term cost for future demographic, economic, and social development.
Standing on the shoulders of giants or science? Lessons from ordoliberalism
Authors: Feld Lars P. , Köhler Ekkehard A. 
Published: May 2023

AbstractJames Buchanan would have celebrated his 100th birthday in 2019. This serves as an inspiration to look at the future of public choice and the question of how much normativity public choice can bear. In our analysis we draw parallels between public choice and German ordoliberalism (and its source in the Freiburg School of Economics). We argue that the reception of ordoliberalism exemplifies easy-to-grasp pitfalls that should be taken seriously. We anchor the future agenda of public choice in a solid individualist perspective. Similar to ordoliberalism, public choice will have to clarify its relation to normative economics. The effects of rules and institutions and their working properties should be thoroughly analyzed empirically. The role of ideas is important for the normative foundation of both public choice/ constitutional economics and ordoliberalism, and is rooted in normative individualism. It provides a benchmark by which rules and institutions can be judged as favorable.
Development and Characterization of Multilayered Cu/HA/ZnS + PEEK Coating System by Hybrid Technology
Authors: Kuśmierczyk Filip , Cieniek Łukasz , Kopia Agnieszka , Zimowski Sławomir , Moskalewicz Tomasz 
Published: May 2023

AbstractIn this study, multilayered Cu/HA/ZnS + PEEK coatings were fabricated using hybrid technology on Zr–2.5Nb alloy substrates. The use of electrophoretic deposition (EPD) and heat treatment allowed the 1st base composite ZnS + PEEK layer and the 2nd hydroxyapatite (HA) top layer to be obtained. The EPD kinetics of both layers was studied. Heating at a temperature of 450 °C and slow cooling resulted in densification and sulfonation of PEEK. It also led to an increase in the adhesion of HA particles on the surface of the PEEK + ZnS layer and to the settlement of HA particles deep into the 1st layer. The effect of substrate preparation on the adhesion strength of coatings was investigated. The ZnS + PEEK layer exhibited high adhesion to the chemically treated zirconium alloy. Furthermore, the first layer was characterized by a high scratch resistance. The selective distribution of Cu on the top of the coating was obtained by shadow-masked pulsed laser deposition (PLD). The multilayered coatings exhibited high roughness and mild hydrophobicity. This study showed the possibility of obtaining a multilayered coating system with a controlled distribution of bioactive components (HA) and antimicrobial components (Cu) on its surface using a hybrid method that combined EPD, heat treatment, and PLD.