bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ethics, Sublimity and Hospitality
Authors: Bidgoli Mehrdad , Abbasi Pyeaam 
Published: August 2023

Abstract
This article presents a study of ‘The Rime of the Ancient Mariner’ by Coleridge and ‘Resolution and Independence’ by Wordsworth. The readings are mainly addressed by the philosophy of Emmanuel Levinas and try to present a conception of sublimity which mainly revolves around ethical awareness and sensibility so as to gauge the extent to which they can possibly hint at ethical issues at stake. We propose that these poetic works deal with the other and the sublimity of the encounter between the self and the other. Each of these works offers similar images of the self before the encounter – that of dwelling, self-preoccupation and enjoyment – but the speakers come out of the encounter differently: in ‘The Rime’, the Mariner roams throughout the country and recounts his experience for other ‘others’ in the hope of spreading what he now can probably identify as ‘the Good’; in ‘Resolution and Independence’, the speaker simply comes out of the unsettling and sublime encounter with the leech-gatherer enlightened and mindful of the other. The conclusion is that one significant part of the idea of the sublime in Romanticism deals with irreducible alterities – cosmic/ontic as well as (more importantly) human – and while they ineluctably reduce them to the language of poetry, each treatment can be evaluated by analysing how well they express the ruptures and interstices of alterity within a language which can go beyond language.
Ganoderma lucidum Fruiting Body Dry Extract inhibits cell proliferation and induces apoptosis in breast cancer cells by activating both caspase-8 and caspase-9.
Authors: GÖKTEPE Özge , ÇINAR Venhar , HAMURCU Zuhal , YAKAN Birkan 
Published: August 2023

Breast cancer is one of the most prominent causes of mortality among women worldwide due to factors such as aggressive behavior of the cancer and resistance to chemotherapeutic agents. Resistance to chemotherapeutic drugs in cancer treatment is a common phenomenon, especially in progressive diseases with a high prevalence. Therefore the current study aimed to demonstrate the anti-cancer effects of GL on MDA-MB-231 and MCF-7 cell lines.
We showed the effect of GL on cell proliferation using the MTS method, its effect on clone formation with a clonogenic test, and we also evaluated whether the apoptotic pathway was activated by western blot.
GL significantly inhibited cell proliferation depending on the dose in MDA-MB-231 and MCF-7 cell lines and it significantly reduced the number of colonies compared to non-treated cells. In addition, GL induced the initiation of apoptosis in MDA-MB-231 and MCF-7 cells, as evidenced by an enhanced level of caspase-8 and caspase-9 and decreased expression of PARP.
These results demonstrated the molecular mechanism underlying the anti-cancer effects of GL, suggesting that GL might be useful in anticancer therapy. Novel products, such as GL, undoubtedly have promise for the future.
Krisis Energi Uni Eropa: Tantangan dan Peluang dalam Menghadapi Pasokan Energi yang Terbatas
Authors: Logayah Dina Siti , Rahmawati Regina Putri , Hindami Daine Zahra , Mustikasari Bella Rizky 
Published: August 2023

The energy crisis is one of the biggest challenges facing the world today. In recent decades, energy demand has increased dramatically due to global population growth, industrial developments, and increasing living standards. The conflict between Russia and Ukraine started in 2014 when Russia annexed the Sevastopol region of Ukraine. This conflict was neglected for years until it finally reached its peak in 2022. This conflict became one of the factors in the energy crisis that occurred in Europe. Several countries in Europe have declared an energy crisis. Some of these European countries include Germany, Sweden, the Netherlands, Austria and Denmark. The purpose of writing this article is to find out what are the challenges and opportunities faced due to the energy crisis in Europe. The method used in writing this article is to use a literature review approach by selecting the database source to be used, downloading and processing text and citation files with Mendeley. The results of this study from the existence of an energy crisis in Europe can have an impact both in the economic field and in the lives of its people. The opportunities that arise are investment in renewable energy, the emergence of energy-saving attitudes, further development of energy infrastructure, the emergence of energy technology innovations, and finally, increased international cooperation.

Krisis energi adalah salah satu tantangan terbesar yang dihadapi dunia saat ini. Dalam beberapa dekade terakhir, permintaan energi telah meningkat secara dramatis karena pertumbuhan populasi global, perkembangan industri, dan peningkatan standar hidup. Konflik antara Rusia dan Ukraina dimulai pada tahun 2014 ketika Rusia mencaplok wilayah Sevastopol di Ukraina. Konflik ini terbengkalai selama bertahun-tahun hingga akhirnya mencapai puncaknya pada tahun 2022. Konflik tersebut menjadi salah satu faktor terjadinya krisis energi yang terjadi di Eropa. Beberapa negara di Eropa telah menyatakan adanya krisis energi. Beberapa negara di Eropa tersebut diantaranya Jerman, Swedia, Belanda, Austria, dan Denmark. Tujuan dari penulisan artikel ini yaitu untuk mengetahui apa saja tantangan serta peluang yang dihadapin akibat terjadinya krisis energi di eropa ini. Adapun metode yang digunakan dalam penulisan artikel ini yaitu dengan menggunakan pendekatan literature review dengan memilih database sumber yang akan digunakan, mengunduh dan memproses teks dan file kutipan dengan Mendeley. Hasil dari penelitian ini Dari adanya krisis energi di Eropa dapat memunculkan dampak baik di segi ekonomi dan kehidupan masyarakatnya. Adapun peluang yang muncul yaitu investasi terhadap energi terbarukan, munculnya sikap hemat energi, mengembangkan lagi infrastruktur energi, munculnya inovasi teknologi energi, dan yang terakhir yaitu meningkatnya kerjasama internasional.
Mechanical And Glucose Stimulation Of Bovine Chondrocytes Affect ECM Synthesis
Authors: Lecce Christian 
Published: August 2023

<p>Â Loss of articular cartilage is a cause of human morbidity which can potentially be cured with exogenous cartilage replacements. Although more research is required to create functional cartilage inserts, mechanical stimulation of chondrocytes (cartilage cells) in the correct media formulation may improve extracellular matrix (ECM) production, leading to a better-quality cartilage insert. This study aimed to identify the effect of unconfined dynamic compression of bovine chondrocytes seeded in agarose constructs on ECM production in different initial media glucose concentrations. Unstimulated constructs did not produce significantly different amounts of collagen or glycosaminoglycan (GAG) in response to different media glucose concentrations. Also, stimulated construct ECM production did not significantly differ from control constructs in each glucose concentration investigated. However, stimulated constructs in 10 mM glucose produced more collagen and GAG than in media containing 25 mM glucose. Analysis of the yield of lactate on glucose (YL/G) showed that stimulated constructs underwent more aerobic respiration as the glucose media concentration increased, which did not occur for control constructs. Culturing chondrocytes in media containing 10 mM glucose lead to more ECM production than media containing 25 mM glucose and should be used in future stimulation studies. Â </p>
The Impact Of COVID-19 On Reusable Cup Sharing Programs: A Qualitative Exploration Of Community-Based Social Marketing
Authors: Friedman Noah 
Published: August 2023

<p>This qualitative case study explores reusable cup sharing programs in the context of the COVID-19 crisis that triggered heightened hygiene concerns. These community-based programs encourage consumers to switch from disposable to reusable cups when purchasing takeaway drinks at coffee shops. Reusable cup sharing program owners worldwide were interviewed in June 2020 on the impacts of the coronavirus pandemic and how they responded to the crisis situation. A key theoretical contribution emerged by applying community-based social marketing to this crisis context. By revising the framework from a linear to a cyclical program development process, programs are better equipped to respond to changes in the external environment through continuous monitoring. This research provides practical insights for reusable cup sharing programs and other community-based programs to build resilience to future global crises.Â </p>
Rapid detection of Pseudomonas aeruginosa by recombinase polymerase amplification combined with CRISPR-Cas12a biosensing system
Authors: Liu Shuang , Huang Siyuan , Li Fang , Sun Yuanyuan , Fu Jin , Xiao Fei , Jia Nan , Huang Xiaolan , Sun Chunrong , Zhou Juan , Wang Yi , Qu Dong 
Published: August 2023

Pseudomonas aeruginosa (P. aeruginosa) is an important bacterial pathogen involved in a wide range of infections and antimicrobial resistance. Rapid and reliable diagnostic methods are of vital important for early identification, treatment, and stop of P. aeruginosa infections. In this study, we developed a simple, rapid, sensitive, and specific detection platform for P. aeruginosa infection diagnosis. The method integrated recombinase polymerase amplification (RPA) technique with clustered regularly interspaced short palindromic repeat (CRISPR)–CRISPR-associated protein 12a (Cas12a) biosensing system and was termed P. aeruginosa–CRISPR–RPA assay. The P. aeruginosa–CRISPR–RPA assay was subject to optimization of reaction conditions and evaluation of sensitivity, specificity, and clinical feasibility with the serial dilutions of P. aeruginosa genomic DNA, the non–P. aeruginosa strains, and the clinical samples. As a result, the P. aeruginosa–CRISPR–RPA assay was able to complete P. aeruginosa detection within half an hour, including RPA reaction at 42°C for 20 min and CRISPR-Cas12a detection at 37°C for 10 min. The diagnostic method exhibited high sensitivity (60 fg per reaction, ~8 copies) and specificity (100%). The results of the clinical samples by P. aeruginosa–CRISPR–RPA assay were consistent to that of the initial result by microfluidic chip method. These data demonstrated that the newly developed P. aeruginosa–CRISPR–RPA assay was reliable for P. aeruginosa detection. In summary, the P. aeruginosa–CRISPR–RPA assay is a promising tool to early and rapid diagnose P. aeruginosa infection and stop its wide spread especially in the hospital settings.
Corin deficiency impairs cardiac function in mouse models of heart failure
Authors: Niu Yayan , Zhou Tiantian , Zhang Shengnan , Li Wenguo , Wang Kun , Dong Ningzheng , Wu Qingyu 
Published: August 2023

IntroductionCorin is a protease in the natriuretic peptide system. Deleterious CORIN variants are associated with hypertension and heart disease. It remains unclear if and to what extent corin deficiency may contribute to heart failure (HF).MethodsCorin knockout (KO) mice were used as a model. Cardiac function was assessed by echocardiography and tissue analysis in Corin KO mice at different ages or subjected to transverse aortic constriction (TAC), which increased pressure overload. Heart and lung tissues were analyzed for cardiac hypertrophy and lung edema using wheat germ agglutinin, Sirius red, Masson's trichrome, and Prussian blue staining. Recombinant corin was tested for its effect on cardiac function in the TAC-operated Corin KO mice. Selected gene expression in the heart was examined by RT-PCR. ELISA was used to analyze factors in plasma.ResultsCorin KO mice had progressive cardiac dysfunction with cardiac hypertrophy and fibrosis after 9 months of age, likely due to chronic hypertension. When Corin KO mice were subjected to TAC at 10–12 weeks of age, cardiac function decreased more rapidly than in similarly treated wild-type mice. When the TAC-operated Corin KO mice were treated with recombinant corin protein, cardiac dysfunction, hypertrophy, and fibrosis were ameliorated. The corin treatment also decreased the gene expression associated with cardiac hypertrophy and fibrosis, increased plasma cGMP levels, lowered plasma levels of N-terminal pro-atrial natriuretic peptide, angiotensin II, and aldosterone, and lessened lung edema in the Corin KO mice subjected to TAC.ConclusionCorin deficiency impairs cardiac function and exacerbates HF development in mice. Corin protein may be used to reduce cardiac hypertrophy and fibrosis, suppress the renin-angiotensin-aldosterone system, and improve cardiac function in HF.
Incremental predictive utility of a radiomics signature in a nomogram for the recurrence of atrial fibrillation
Authors: Zheng Dongyan , Zhang Yueli , Huang Dong , Wang Man , Guo Ning , Zhu Shu , Zhang Juanjuan , Ying Tao 
Published: August 2023

BackgroundRecurrence of atrial fibrillation (AF) after catheter ablation (CA) remains a challenge today. Although it is believed that evaluating the structural and functional remodeling of the left atrium (LA) may be helpful in predicting AF recurrence, there is a lack of consensus on prediction accuracy. Ultrasound-based radiomics is currently receiving increasing attention because it might aid in the diagnosis and prognosis prediction of AF recurrence. However, research on LA ultrasound radiomics is limited.ObjectiveWe aim to investigate the incremental predictive utility of LA radiomics and construct a radiomics nomogram to preoperatively predict AF recurrence following CA.MethodsA training cohort of 232 AF patients was designed for nomogram construction, while a validation cohort (n = 100) served as the model performance test. AF recurrence during a follow-up period of 3–12 months was defined as the endpoint. The radiomics features related to AF recurrence were extracted and selected to create the radiomics score (rad score). These rad scores, along with other morphological and functional indicators for AF recurrence, were included in the multivariate Cox analysis to establish a nomogram for the prediction of the likelihood of AF recurrence within 1 year following CA.ResultsIn the training and validation cohorts, AF recurrence rates accounted for 32.3% (75/232) and 25.0% (25/100), respectively. We extracted seven types of radiomics features associated with AF recurrence from apical four-chamber view echocardiography images and established a rad score for each patient. The radiomics nomogram was built with the rad score, AF type, left atrial appendage emptying flow velocity, and peak atrial longitudinal strain. It outperformed the nomogram building without the rad score in terms of the predictive efficacy of CA outcome and showed favorable performance in both cohorts.ConclusionWe revealed the incremental utility of a radiomics signature in the prediction of AF recurrence and preliminarily developed and validated a radiomics nomogram for identifying patients who were at high risk of post-CA recurrence, which contributed to an appropriate management strategy for AF.
Physiological reactivity to acute mental stress in essential hypertension—a systematic review
Authors: Walther Lisa-Marie , Wirtz Petra H. 
Published: August 2023

ObjectiveExaggerated physiological reactions to acute mental stress (AMS) are associated with hypertension (development) and have been proposed to play an important role in mediating the cardiovascular disease risk with hypertension. A variety of studies compared physiological reactivity to AMS between essential hypertensive (HT) and normotensive (NT) individuals. However, a systematic review of studies across stress-reactive physiological systems including intermediate biological risk factors for cardiovascular diseases is lacking.MethodsWe conducted a systematic literature search (PubMed) for original articles and short reports, published in English language in peer-reviewed journals in November and December 2022. We targeted studies comparing the reactivity between essential HT and NT to AMS in terms of cognitive tasks, public speaking tasks, or the combination of both, in at least one of the predefined stress-reactive physiological systems.ResultsWe included a total of 58 publications. The majority of studies investigated physiological reactivity to mental stressors of mild or moderate intensity. Whereas HT seem to exhibit increased reactivity in response to mild or moderate AMS only under certain conditions (i.e., in response to mild mental stressors with specific characteristics, in an early hyperkinetic stage of HT, or with respect to certain stress systems), increased physiological reactivity in HT as compared to NT to AMS of strong intensity was observed across all investigated stress-reactive physiological systems.ConclusionOverall, this systematic review supports the proposed and expected generalized physiological hyperreactivity to AMS with essential hypertension, in particular to strong mental stress. Moreover, we discuss potential underlying mechanisms and highlight open questions for future research of importance for the comprehensive understanding of the observed hyperreactivity to AMS in essential hypertension.
How is carbonate crust digested by magma?
Authors: Borisova Anastassia Y. , Bohrson Wendy A. 
Published: August 2023

Magma’s volatile budget depends on deep magmatic sources, the degree of differentiation and degassing conditions, and volatile input from the assimilated crust. It is, therefore, important to know the exact mechanism by which the crust is assimilated into magma to understand volatile budgets and eruption behavior. To explore reactions between carbonate, calc–silicate, or skarn xenoliths and basaltic andesite magma, we studied ten calc–silicate xenoliths from the 1994, 1998, 2006, and 2010 Merapi eruptions and four sediment samples of local Javanese carbonate crust. An in situ electron probe microanalysis of the 1994–2010 calc–silicate xenolith minerals and glasses suggests that calcite is a minor and metastable mineral phase in association with wollastonite. In addition, carbonate melts quenched to calcic glasses (32 ± 7 wt% SiO2; 38 ± 3 wt% CaO), similar to experimental glasses produced by crust–melt interaction experiments. Thermodynamic modeling using rhyolite MELTS (version 1.2.0) predicts the production of highly silicic (up to ∼84 wt% of SiO2) and CaO-rich (up to ∼25 wt%) melts during partial melting of calc–silicate material. The observed mechanism of calc–silicate xenolith assimilation is the generation of highly silicic (77 ± 4 wt% of SiO2) melts in association with idiomorphic diopside [Wo49En29; 57 ± 3 Mg# = Mg/(Mg+Fe2+)] and other calcic pyroxenes (Wo54-82 En2-21; 16–43 Mg#) due to partial melting of xenolith and incongruent dissolution reactions. We hypothesize that the rate-limiting process is the subsequent mixing of the produced crustal melts with representative resident andesitic melt (average 65 wt% SiO2) through chemical diffusion, which explains major and volatile (Cl) element contents in the Merapi glass products. In addition to high Sr contents and radiogenic 87Sr/86Sr and elevated CO2, Ba, Co, Cr, Cu, V, Zn, and Zr contents in the magmatic minerals and associated glasses, the recrystallized and residual metamorphic sphene, quartz, garnet, and apatite predicted by rhyolite-MELTS or Magma Chamber Simulator modeling during wallrock melting and residual metastable calcite and wollastonite are important tracers of calc–silicate crust assimilation. The disequilibrium process of calc–silicate crustal assimilation can, thus, be well predicted by dissolution experiments and thermodynamic modeling using rhyolite-MELTS or Magma Chamber Simulator. The rate of calc–silicate crustal assimilation is still unconstrained without adequate high-temperature kinetic time-series experiments. We predict that the crustal assimilation rate is controlled by the Si–Al diffusion and associated convection in the hydrous silicate magma.
Estimation of reservoir temperature and analysis of the mechanism of origin of a granite dome-controlled geothermal system in the western Wugongshan area, southeast China
Authors: Wang Luyao , Liu Kai , Zhang Shouchuan , Zhang Yaoyao , Jia Wuhui , Yu Tingxi , Guo Junhan 
Published: August 2023

The escalating issues of worldwide energy scarcity and environmental contamination have brought geothermal resources into the spotlight as a sustainable and eco-friendly energy alternative. The circum-Wugongshan geothermal belt has abundant geothermal resources at a medium-low temperature, offering significant potential for development and utilization. In this study, samples of geothermal groundwater, cold spring water, and surface water were collected from the western Wugongshan area. Hydrochemical and thermodynamic methods were used to estimate the reservoir temperature and analyze its mechanism of origin. The results of these analyses indicated that, in terms of hydrochemical characteristics, most geothermal groundwater samples were Na-HCO3 and Na-SO4, while cold spring and surface water samples were Na-HCO3 and Ca-HCO3, respectively. Quartz and multicomponent geothermometers provided the most reliable estimations of reservoir temperatures, ranging from 64.8°C to 93.4°C. The circulation depth of geothermal water was found to range from 1729.3 m to 2,292.5 m. A mixing model indicated that shallow cold water was blended at a rate of 62.1%–78.8%. The δD and δ18O values validated the conclusion that the geothermal water originates from atmospheric precipitation, with recharge elevations varying between 503.1 m and 1,375.6 m. Based on the above analysis, a conceptual model is proposed to illustrate the mechanism of geothermal groundwater genesis.
Inclusive Science Communication training for first-year STEM students promotes their identity and self-efficacy as scientists and science communicators
Authors: Alderfer Sydney , McMillan Rachel , Murphy Katlyn , Kelp Nicole 
Published: August 2023

IntroductionIt is critical for STEM students to be able to discuss science with diverse audiences, yet many STEM students do not receive adequate training in these skills. When students have the skills to communicate about science, they may feel a resulting sense of empowerment as a scientist as well as help members of society understand science.MethodsIn this study, we developed, implemented, and evaluated a workshop that gave students understanding of and practice in applying Inclusive Science Communication. We assessed the workshop via a mixed-methods approach.ResultsWe quantified student affective measures that are associated with STEM persistence, such as science self-efficacy and science identity, showing that the workshop increased these measures both for students of marginalized identities and for students who do not hold these identities. We also assessed student open-ended responses for themes related to the Theory of Planned Behavior, Community Cultural Wealth, and White Supremacy Culture, finding that forms of cultural capital empowered students to perform science communication behaviors while power imbalances, fear of conflict, and perfectionism presented barriers to these behaviors.DiscussionThis study highlights the importance of providing explicit training and practice in Inclusive Science Communication for undergraduate STEM students. Our results also suggest that students need the opportunity for reflexivity – that is, the practice of reflecting upon their identities and motivations – in order to develop in their identity and confidence as scientists and science communicators.