bluuebunny/crossref_metadata_2025_split huggingface dataset:
Co-Delivery of Cisplatin and Curcumin Using Mesoporous Silica Nanoparticles
to Improve their Anticancer Effects
Authors: Sharifi Simin , Abdolahinia Elaheh Dalir , Dizaj Solmaz Maleki , Bolouri Ebrahimi Seyyedeh Saba , Jafari Sadaf , Basiri Anita , Yazdani Javad 
Published: March 2023

Aims:
This study aimed to prepare and evaluate the physicochemical and anticancer properties
of cisplatin and curcumin-loaded mesoporous silica nanoparticles (Cis-Cur-MSNs).

Background:
In recent years, combination treatment has attained better outcomes than monotherapy in
oncology. Cis-Cur-MSNs were prepared by precipitation technique.

Objective:
The objective of the present study was the evaluation of the physicochemical and anticancer
properties of cisplatin and curcumin-loaded mesoporous silica nanoparticles (Cis-Cur-MSNs).

Methods:
The prepared materials were assessed in terms of physicochemical methods. The drug release
pattern from the MSNs was also evaluated via ultraviolet spectrophotometry. In addition, the porosity
and surface area of prepared nanoparticles were determined using the Brunauer-Emmett-Teller (BET)
technique. The cytotoxicity of Cis-Cur-MSNs was evaluated on the HN5 cells as head and neck squamous
carcinoma cell lines. Furthermore, ROS production of Cis-Cur-MSNs treated cells was evaluated
compared with untreated cells.

Results:
According to the results, prepared nanoparticles displayed nanometer size, rod morphology,
and negative surface charge with mesoporous structure belonging to the MCM-41 family (twodimensional
hexagonal). Regarding the results of BET adsorption and desorption isotherm analysis for
Cis-Cur-MSNs and drug-free MSNs, pore diameter, pore volume, specific surface area, and drug-loaded
pore area in MSNs were decreased. In the first 10 days, the prepared nanoparticles exhibited a relatively
rapid release pattern for cisplatin and curcumin, and until the 35th day, the release of them from the
MSNs continued slowly.

Conclusion:
The cytotoxic effect of Cis-Cur-MSNs was significantly more than Cur-MSNs and Cis-
MSNs in 24 and 48 h incubation time (p < 0.05). The results suggest that Cis-Cur-MSNs may be beneficial
in the development of a cancer treatment protocol.

Others:
The prepared nanoparticle in the present study could be a potential biomaterial for cancer
treatment.
Platform economies: Beyond the North-South divide
Authors: Roitman Janet 
Published: March 2023

AbstractPlatform economies are depicted as the foundation for a new era of economic production. This transpires through the incorporation of digital technologies and algorithmic operations into the heart of economic and financial practices. However, different assumptions are made about the effects of digital platforms depending on geographical location. While digital platforms are approached as inherent to processes of financialization globally, they are reduced to processes of financial inclusion when referencing the ‘Global South’. Analyses of financialization as a one-way-vector - Global North to Global South - overlook the variability, the limits, and responses to financialization. In contrast, a focus on market devices illustrates the specificities of value creation. An example of this is ‘the float’, a form of financial value generated by mobile telecommunication operators, mobile money issuers, and commercial banks in Africa. Through this lens, we see instances of both value subjugation and autonomization, evidence that the fault lines of value production generated by ambiguous market devices are obscured by the Global North/Global South frame.
Presupuesto Municipal
Authors: Mamani Livia Tania 
Published: March 2023

Los presupuestos municipales son herramientas fundamentales para la planificación, análisis, monitoreo y control de los recursos municipales. Ya que permiten visualizar en términos cuantitativos y monetarios los recursos a emplear, como asi también las prioridades que se atienden en beneficio de la población.
En este marco, este trabajo se propone conocer el procedimiento habitual y determinar la brecha entre la formulación de los presupuestos municipales de la Cuenca Carbonífera y lo solicitado por la doctrina y la normativa legal.
Para ello se realizo una lectura previa del material normativo nacional, provincial y municipal que comprende dicho proceso, seguido de una entrevista semiestructurada con el fin de obtener información directa de los sujetos intervinientes en dicho proceso durante los últimos tres años. Estos describieron el procedimiento habitual para formular el presupuesto.
Este proceso requiere de actividades trabajadas en conjunto con diferentes miembros del municipio. El procedimiento habitual para formular el presupuesto municipal de ambas localidades, en términos generales, coincide con lo dictado por la normativa legal nacional, provincial y local.
Su formulación puede verse afectada por cuestiones o alteraciones de diferente índole, como las basadas en cuestiones de línea política, experiencias personales, niveles educativos, circunstancias personales, motivación, situaciones coyunturales de la sociedad, entre otras. Cada funcionario ha tratado de tomar medidas para mejorar e incrementar la recaudación de impuestos y además poder realizar un uso eficiente de los recursos disponibles por cada municipalidad de la Cuenca Carbonífera
PENGGUNAAN APLIKASI AGROPED DALAM MENINGKATKAN PEMASARAN HASIL PERTANIAN DAN SEBAGAI SARANA KONSULTASI BAGI PETANI
Authors: Andrian Rico , Timotiwu Paul Benyamin , Manik Tumiar Katarina , Pramono Eko 
Published: March 2023

Produk pertanian baik buah buahan, sayuran dan bunga (hortikultura) maupun produk tanaman pangan terbatas dipasarkan secara lokal. Penyuluh lapangan dan para petani di lokasi itu sangat membutuhkan informasi pengetahuan pertanian maupun komunikasi untuk konsultasi permasalahan di lapang. Tetapi, karena jarak yang cukup jauh dari ibukota (khususnya dari Universitas Lampung sebagai sumber pakar pertanian) diperlukan metode diseminasi hasil penelitian dari Universitas Lampung dan juga media komunikasi melalui aplikasi online. Sekelompok dosen Universitas Lampung telah mengembangkan suatu aplikasi yang diberi nama AGROPED. AGROPED merupakan sebuah aplikasi Pertanian Lampung berbasis mobile yang dibuat sebagai alternatif bagi para petani untuk memasarkan hasil pertanian, mendapatkan konsultasi pertanian dan informasi terkait dengan pertanian. Petani akan dilatih bagaimana menjadi pelanggan AGROPED dan memanfaatkan fitur didalamnya termasuk fitur e-commerce dan konsultasi permasalahan. Kegiatan pengabdian ini bertujuan memperkenalkan, dan mempraktekkan aplikasi AGROPED kepada petani dan setidaknya petani penjual dan petani aktif menggunakan fitur konsultasi. Dalam pemasaran, 52% menjualnya kepada pengepul, dan 17.5 % menjualnya keberbagai kesempatan (pasar, pengepul, diambil langsung oleh pedagang). Berkaitan dengan aplikasi internet, 90.1 % petani yang di-survey memiliki HP Android, tetapi belum banyak digunakan untuk usaha tani mereka, 77.2% belum pernah menggunakan internet untuk mencari informasi harga, hanya 56.8% menggunakan internet untuk mencari info tentang pertanian.
PRODUKSI PAPAN PARTIKEL BERBAHAN DASAR SEKAM PADI DAN POLYSTYRENE
Authors: Humaira Tariza , Kurniawan Bagus , At-Tsaqib Jenner Hawckins , Hasanah Safirda 
Published: March 2023

Sampah styrofoam dan limbah sekam padi turut berkontribusi dalam permasalahan lingkungan. Lignoselulosa dalam sekam dan sifat termoplastik dari styrofoam berpeluang dimanfaatkan dalam pembuatan papan partikel. Penelitian ini bertujuan untuk mengetahui komposisi terbaik pada pembuatan papan partikel dari sekam padi dan styrofoam agar dihasilkan sifat fisis serta Internal Bond (IB) yang terbaik berdasarkan SNI 03-2105-2006. Sekam yang telah dipreparasi dicampurkan dengan perekat (50:50) yang dibuat dengan cara melarutkan styrofoam dalam silena. Pada beberapa papan partikel ditambahkan compatibilizer berupa MA, BPO dan DVB. Setelah semua tercampur merata, kemudian dipress menggunakan hotpress pada suhu 1600C selama 30 menit. Papan yang telah jadidijemur dibawah matahari dan dibiarkan disuhu ruang. Lalu, dilakukan uji sifat fisis dankuat tarik. Papan partikel dengan MA, BPO, DVB adalah yang terbaik dengan nilaikerapatan sebesar 0,689 g/cm3, kadar air sebesar 3,61%, pengembangan tebal sebesar 2,04%.Sedangkan, papan partikel dengan MA, BPO memiliki nilai IB terbaik, yaitu 24,227 kg/cm2. Sampah styrofoam dan limbah sekam padi turut berkontribusi dalam permasalahanlingkungan. Lignoselulosa dalam sekam dan sifat termoplastik dari styrofoam berpeluangdimanfaatkan dalam pembuatan papan partikel. Penelitian ini bertujuan untuk mengetahuikomposisi terbaik pada pembuatan papan partikel dari sekam padi dan styrofoam agardihasilkan sifat fisis serta Internal Bond (IB) yang terbaik berdasarkan SNI 03-2105-2006.Sekam yang telah dipreparasi dicampurkan dengan perekat (50:50) yang dibuat dengan caramelarutkan styrofoam dalam silena. Pada beberapa papan partikel ditambahkan compatibilizer berupa MA, BPO dan DVB. Setelah semua tercampur merata, kemudiandipress menggunakan hotpress pada suhu 160OC selama 30 menit. Papan yang telah jadidijemur dibawah matahari dan dibiarkan disuhu ruang. Lalu, dilakukan uji sifat fisis dankuat tarik. Papan partikel dengan MA, BPO, DVB adalah yang terbaik dengan nilaikerapatan sebesar 0,689 g/cm3, kadar air sebesar 3,61%, pengembangan tebal sebesar 2,04%.Sedangkan, papan partikel dengan MA, BPO memiliki nilai IB terbaik, yaitu 24,227 kg/cm2.
Teat open lesions can lead to challenges at milking time on dairies in the Northeast United States
Authors: Virkler Paul D. , Wieland Matthias 
Published: March 2023

Abstract
During evaluations of teat skin by the authors using National Mastitis Council procedures, teat open lesions (TOL) have been more commonly identified in dairies in the Northeast United States over the last 10 years. The TOL described here are found in all stages of lactation and in any age lactating cow, which is unique from TOL that present mainly in first lactation animals just after calving. Cows with these TOL exhibit more abnormal cow behaviors during the milking event. Based on the authors’ subjective field evaluations, dry teat skin condition appears to be a significant risk factor. Although there is a paucity of published literature, the other risk factors that the authors have observed are exposure to wind and significant temperature fluctuations, wet bedding, certain bedding additives, and occasionally mechanical, chemical, or thermal trauma. Teat open lesions have been observed in herds with all the common types of bedding. Treatment and preventative measures have focused on supporting skin conditions through higher emollients in the postmilking teat disinfection (PMTD) and controlling the environmental conditions to which the teat is exposed. This includes an evaluation of cow positioning in the stall as well as bedding levels, which influence bedding contamination. The accuracy of PMTD application can also have an influence. The objective of this narrative review was to search the current literature describing TOL, identify knowledge gaps, describe the authors’ field experience with TOL on dairy operations in the Northeast United States, and identify opportunities for future research.
Structural and pragmatic shifts in the development of newspaper headlines in the socialist and democratic period
Authors: Molnárová Patrícia 
Published: March 2023

Abstract
The newspaper headline is the first contact between the author and the recipient and in terms of stylistics, it is one of the compositional aspects of the text. In relation to the text itself, as well as to the communication partner, the headline fulfils an informative, engaging and especially in journalistic genres, persuasive function. Following the previous research focused on the 1960s, the aim of the study is to analyse and compare headlines in Slovak newspapers in the period of totalitarian and democratic establishment with a focus on the journalistic genre. The research sample, excerpted from the official discourse of the Communist Party of Czechoslovakia (1948 – 1956, 1961 – 1970) and the more recent Slovak mainstream e-discourse (2011 – 2021), contains almost 800 headlines to monitor the developmental tendencies of a given text component under the influence of changed extra lingual conditions. The aim of the research is to verify the expected linguistic and communicative modifications captured, for example, in a freer approach to the use of language. The given assumption expected at the structural-pragmatic level is conditioned by the dismantling of political-ideological control of the socialist period. At the stylistic-pragmatic level, we also assume a more direct and qualitatively more elaborate expressiveness in the language.
Language situation and position of Catalan in Northern Catalonia
Authors: Kadlec Jaromír 
Published: March 2023

AbstractThis paper focuses on Northern Catalonia, a territory ceded to France by Spain through the signing of the Treaty of Pyrenees in 1659. The focus is placed not only on the demography and the number of speakers using the Catalan language in Northern Catalonia but also on the linguistic politics and the use of the Catalan language in various areas of social life, especially in education. The school plays the most important role in the revitalization of the Catalan language, and without its active contribution, it is not possible to restore bilingualism in French Catalonia.
Contextual Sensitivity of the Lexemes Učiteľ [Teacher] and Učiteľka [Female Teacher]
Authors: Urbancová Lujza 
Published: March 2023

Abstract
The study deals with the lexical meaning of lexemes female teacher, teacher (male teacher and a generic meaning of the lexeme), which might be in Slovak influenced by context and discourse as well as by attitudes and gender stereotypes of interlocutors. In pragmatic research, the author focuses on semantic indeterminacy as an implicit component of lexical meaning determined by the socialization of interlocutors. Analysis of the lexemes female teacher, teacher and their collocations with the adjectives typical, crazy, burned out, in different contexts, has shown that the gender of the person referred to has an influence on the meaning. The implicit or socialized meaning of the lexemes of the feminine gender is frequently associated with those phenomena that are percieved negatively in society, while the names of the masculine gender do not contain this component.
Effects of Led Lighting Training on Response Time in Greco-Roman Wrestlers
Authors: Gierczuk Dariusz , Bujak Zbigniew , Cieśliński Igor 
Published: March 2023

Abstract

Introduction
Response time is one of the determinants of performance effectiveness in wrestling competitions. Its high levels help wrestlers fight more effectively when performing appropriate technical and tactical actions. Different factors such as a proper warm-up, unexpected situations, muscle fatigue, asthenic reactions, competition prestige and previous injuries may exert an influence on perceptual abilities (including RT and MT) and affect fighting effectiveness. Getting to know determinants of response time may provide a lot of valuable practical information that can be used in wrestling-related training. The study sought to determine changes in response time in Greco-Roman wrestlers produced by LLT.

Material and Methods
Twenty-four Greco-Roman wrestlers (age = 18.6 1.8, years of experience = 6.0 1.6) took part in the study. The wrestlers were divided according to two weight classes (lightweight and heavyweight). Within LLT programme, they performed special motor tasks using Batak Pro (15 minutes in total). Between the tasks, response time (reaction time and movement time) was measured. Reaction time test (RT, version S1) of the Vienna Test System was used in the study.

Results
Response time changed in a variety of ways (different directions and intensity of changes). The changes were noted both in RT and MT. Contrary to LLT, a standard warm-up did not contribute to an improvement in RT. The greatest changes were observed after ten minutes of exercising. Intragroup differences in response time grew smaller in the course of the task performance. No differences in response time were noted between wrestlers representing different weight classes.

Conclusions
Physical exertion within LLT affects response time in Greco-Roman wrestlers regardless of their weight classes. The most favourable changes occur after 10 minutes of exercising that requires high attentional focus (exercises performed after a standard warm-up). The type of warm-up and the exercises used may constitute a factor improving performance effectiveness. It is recommended that in a pre-competition warm-up, more time should be devoted to exercises requiring high attentional focus.
The Influence of Caffeine and Guarana on Dehydration of Young Soccer Players and Physiological Aspects of Dehydration of the Athlete's Body
Authors: Mizera Krzysztof , Kłosek Michał , Kęska Anna , Pilis Wiesław 
Published: March 2023

Abstract

Introduction
The aim of the study was to assess the effect of caffeine and caffeine with guarana on the dehydration of young soccer players and the effect of dehydration on their reaction time.

Material and Methods
The study involved 57 players aged 16.8 ± 0.5 years, with an average body weight of 66.5 ± 9.3 kg, and height 178 ± 6.7 cm. An analysis of the body composition was performed. Thus, the results regarding body weight, adipose tissue, muscle tissue, BMI and body hydration were obtained. Next, the competitors performed successively a test for reaction time and speed over a distance of 5 and 15 meters with the use of photocells. After the tests, the players were randomized into 3 groups, where they received 200 mg caffeine, caffeine + guarana (200 mg + 40 mg), and placebo. Then, the players participated in a soccer training of medium intensity on the pitch, which lasted about 60 minutes. Immediately after completing the training, the procedure for testing reaction time and speed as well as body composition analysis were repeated.

Results
Water loss occurred in each of the study groups and was the highest in players consuming caffeine with guarana and caffeine, but these were not statistically significant differences compared to placebo. Lower BMI correlated with water loss; however, statistically significant differences were noticed only in the placebo group (p ---lt--- 0.001). Water loss also correlated with a smaller decrease in speed over a distance of the 5-meter sprint (p ---lt--- 0.039) and the 15-meter sprint (p ---lt--- 0.035), but only in the caffeine-guarana group.

Conclusions
Caffeine consumption in the amount of about 3 mg/kg of body weight and also caffeine with guarana did not result in significantly greater loss of water in young soccer players. The loss of water during training in players was almost 0.7 l and did not affect the reaction time. The obtained results are important in the context of consuming supplements based on caffeine and guarana for young footballers in order to improve parameters such as speed or reaction time. However, it is also worth conducting research on a group of adult players.
Comparison of Performance in Mechanised Agricultural Tasks Between Precision and Conventional Agriculture on Farms in Tolima (Colombia)?
Authors: Rodríguez Juan José Ortiz , Marín Juan Gonzalo Ardila , Montiel Diana Carolina Polania 
Published: March 2023

Purpose: Agricultural work in Colombia, particularly in small and medium-sized farms, is lagging behind in terms of technology; advances such as precision agriculture (PA) are unknown. This project managed to promote the implementation of PA technologies in the primary tasks of land adaptation, by comparing efficiency indices when conventional practices were used against the use of new technologies.

Theoretical framework: The company CasaToro SA, with its John Deere® agricultural line, allowed the implementation of StarFire TM6000®, 4240® Monitors, Auto Track 200®, and JDLink® technologies, and the use of T3RRA CUTTA® software, in tractors of its brand in different farms in Tolima, Colombia.

Method/design/approach: Measurements of time and area worked in situ were taken and the data obtained were statistically compared using Analysis of Variance (ANOVA).

Results and conclusion: Finding significant differences in tasks such as contour line drawing, which reported a decrease of up to 30% in the time needed in h ha–1, and in primary tillage with discs with increases of up to 13% of the tilled area in ha h–1.

Research implications: In conclusion, in Tolima, which has extensive areas of agricultural production, the implementation of PA can improve yields and reduce production costs.

Originality/value: To demonstrate the benefits of PA.
Organizational Dynamics in Civil Construction: Sector Study on Corporate Social and Environmental Responsibility in Companies in Brazil, Mexico and the United States of America
Authors: Garcia Fernando Marcos , Pereira Vilmar Alves , Da Silva Rodrigo Florêncio 
Published: March 2023

Purpose: This study aims to carry out a sectoral field study on corporate socio-environmental responsibility in companies in the civil construction sector operating in Brazil, Mexico and the United States of America.

Theoretical framework: The bibliographic review demonstrated the results found from a comparative bias in relation to corporate socio-environmental responsibility. It also points out that companies in the civil construction sector in the three countries analyzed (Brazil, Mexico and the United States) have similar environmental and social practices, verifying the adoption of sustainable construction methods, mitigation of the generation of solid waste, as well as their best destination, reuse of water, improvement of energy efficiency, identifying the main focus on reducing greenhouse gas (CO2) emissions.

Method/design/approach: As a methodology, a multicase study was carried out, making use of documentary research, through which a survey of data and information was carried out in a group of companies in the civil construction sector based in three different countries: Brazil, Mexico and the United States. United of America.

Results and conclusion: In all analyzed companies there was a concern that their actions are based on international standards in order to obtain certification, highlighting among them ISO and LEED.

Research implications: The research makes an effective contribution by demonstrating the potential and the need to adopt sustainable practices in the management of contemporary companies.

Originality/value: The results obtained in this study are unprecedented, innovative and relevant to the scientific community, in the context of sustainability in civil construction.

Keywords: Social and environmental responsibility, Construction, Organizational dynamics, Sustainable Practices, Sustainable construction methods.