bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of Adiponectin Resistance on Coronary Artery Disease Severity
Authors: Stojanovic S , Ilic MD , Ilic S , Saric S , Stojanović S , Petrovic V 
Published: August 2023

ABSTRACT

Background:
The serum adiponectin level (AD), adiponectin resistance (AD-R) may reflect the degree of metabolic syndrome (MetS). The role parameter AD-R, The Homeostasis Model Assessment-Adiponectin (HOMA-AD) index on the coronary artery disease (CAD) severity is not still understood.

Objective:
To determine adiponectin concentration and HOMA-AD index in patients with CAD with/without MetS and to evaluate their prognostic importance on severity of CAD.

Methods:
This cross-sectional study involved selected 130 examinees which were divided into three groups: CAD+MetS, CAD-MetS, control group (no CAD/MetS). In all examinees values of biochemical and anthropometric parameters were determined. We analyzed the severity of coronary artery lesions from coronary angiography. Total serum adiponectin concentration was measured by ELISA. We calculated atherogenic Gensini scoring system, Duke prognostic index, and HOMA-AD-index.

Results:
Serum adiponectin level was significantly lower in the group with CAD+MetS (p < 0.001) and in CAD-MetS group (p < 0.01), compared to the control group. The HOMA-AD index showed statistically significant positive correlation with the key parameters of MetS, as well as with the parameters of CAD, number of CAD and modified Gensini score. After applying logistic regression analysis the best predictors for CAD were: adiponectin, blood pressure, HOMA-IR index, and HOMA-AD index. The cut-off values of adiponectin ≤1506.38 pg/mL, HOMA-IR index ≥3.91 and HOMA-AD index ≥0.67 were associated with a higher risk of CAD.

Conclusion:
Patients with CAD with or without MetS had low adiponectin levels and this hypoadiponectinemia indicates that AD and HOMA-AD index may be a useful marker for identifying patients at risk for CAD.
Molecular Characterization and Antimicrobial Susceptibility of Methicillin-Resistant Staphylococcus Aureus Isolates from Clinical Samples and Asymptomatic Nasal Carriers in Istanbul (Turkey)
Authors: Dincer SD , Demirci M , Celepler Y , Namal N , Aksaray S , Aktepe OC , Torun MM 
Published: August 2023

ABSTRACT

Background:
Methicillin-resistant Staphylococcus aureus (MRSA) has been a widespread problem in Turkish hospitals.

Aims:
The aim of this study was to investigate the staphylococcal toxin genes of the clinical and nasal MRSA isolates, and their antibiotic resistance profiles.

Materials and Methods:
Isolation of nasal and clinical bacteria was done following standard microbiological methods. The presence of antimicrobial resistance genes (mec A, pvl, tsst-1, and SEs genes) was determined using the real-time polymerase chain reaction (PCR) assay.

Results:
Among nasal MRSA isolates, 66.7% were toxigenic. The distribution of genes was as follows: pvl 26.7%, tsst-1 3.3%, and SEs 36.7%. Therefore, the nasal MRSA isolates had a rate of 23.3% multidrug resistance (MDR) pattern to the non-beta-lactams antibiotics. All (100%) clinical MRSA isolates were found to be toxigenic. The distribution of genes was as follows; pvl 10%, tsst-1 6.7%, and SEs 100%. The clinical MRSA isolates had a rate of 60% MDR.

Conclusions:
Following detection of pvl, tsst-1, and SEs among nasal and clinical MRSA isolates, and the presence of high antimicrobial resistance, the spread of these strains may be an additional factor contributing to the emergence of community-acquired (CA)-MRSA and hospital-acquired (HA)-MRSA. This study is the first to determine the resistance to linezolid and tigecycline in both nasal and clinical MRSA isolates, for the first time in Turkey. All nasal and clinical MRSA isolates were uniformly susceptible to vancomycin and quinupristin-dalfopristin. Our findings show that MRSA infections in Turkey can be empirically treated with vancomycin and quinupristin-dalfopristin based on the lack of demonstrable resistance to these drugs.
Prevalence and Risk Factors of Hypocalcemia Among Pregnant and Non-Pregnant Women in Maiduguri, Nigeria
Authors: Bako B , El-Nafaty AU , Mshelia DS , Gali RM , Isa B , Dungus M M 
Published: August 2023

Background:
Pregnancy is a period of heightened calcium demand necessary for the optimum growth and development of the fetus and placenta. Women with low calcium intake may manifest with hypocalcemia in pregnancy.

Objective:
The aim of this study was to determine the prevalence and risk factors of hypocalcemia among pregnant and non-pregnant women in Maiduguri, Nigeria.

Subjects and Methods:
A comparative cross-sectional study was conducted at the University of Maiduguri Teaching Hospital, Maiduguri from 1st January 2017 to 31st December 2018. For each patient, sociodemographic and clinical characteristics were noted. Serum calcium, phosphate, total protein, and albumin were determined using spectrophometric methods with their specific reagents. The data obtained was analyzed using the SPSS statistical software for windows version 20. Chi-square test, Student t-test and ANOVA were used as appropriate. Odd ratio with multiple logistic regression was used to determine risk factors for hypocalcemia. P value < 0.05 was considered statistically significant.

Results:
A total of 1,500 (1,000 pregnant and 500 non-pregnant) women were analyzed. The mean age, total protein, and albumin were similar in the pregnant and non-pregnant women. However, the non-pregnant women were of higher parity than the pregnant women (3.75 ± 2.79 versus 2.45 ± 2.24, P < 0.001). The staple food of both group were mainly high carbohydrate diets. The prevalence of hypocalcemia was 29.20% among the pregnant women and 14.20% among the non-pregnant women (X2 = 64.34, P < 0.001). The mean serum calcium was lower among the pregnant compared to the non-pregnant women (2.08 ± 0.22 mmol/L versus 2.2 ± 0.19 mmol/L, F = 5.73, P = 0.02). There were no statistically significant differences in the mean serum calcium across the trimesters of pregnancy (F = 1.58, P = 0.21).

Conclusion:
Hypocalcemia in pregnancy is common in our environment and it is associated with anemia in pregnancy, anorexia, and primigravidity while attainment of at least basic education is protective. We recommend routine calcium supplementation in pregnancy and preconception period.
A Clinical Audit of Histopathologically Diagnosed Ossifying Fibroma of the Jaws in a Nigerian Population
Authors: Okechi UC , Anyanechi CE , Saheeb BD 
Published: August 2023

ABSTRACT

Background:
Ossifying fibroma (OF) is a benign tumor of the jaws, which belongs to the group of fibro-osseous lesions, and exhibits slowly progressive growth leading to jaw expansion with well-defined borders.

Objective:
To evaluate the clinical and radiological characteristics of OFs and their treatment.

Materials and Methods:
A 5-year retrospective study was done. The case notes of subjects were retrieved, analyzed, and evaluated. Relevant information about patients was categorized into bio-data, clinical, and radiological. The diagnosis of lesion was made histopathologically by the oral pathologist.

Results:
Forty- five patients' case notes were retrieved and analyzed and the patients' age ranged from 2 to 70 years (mean 29.4 ± 16.9). Majority of the patients (55.5%; P = 0.23) were 10–29 years. There were 16 (35.6%) males and 29 (64.4%) females giving a male: female ratio of 1:1.8 (P = 0.01). The cross-sectional dimension of the tumors measured vertically and horizontally ranges from 1 cm2 to 420 cm2 (mean = 54.7 cm2 ± 82.9). There were 60% in the maxilla and 40% in the mandible (P = 0.014). Most of the lesions (68.9%; P = 0.01) showed patchy opacity and cotton wool appearances. Majority of the lesions were extirpated by enucleation alone (P = 0.01).

Conclusion:
The prevalence of OF among the fibro-osseous lesions was 51.0% while against other benign lesions, it was 16.0%. In conclusion, contrary to most other reports across the globe, this lesion in southeast Nigeria occurred more frequently in the maxilla than mandible.
Managing cholesteatomas with labyrinthine fistula
Authors: Aw Natalie Min Yi , Thong Jiun Fong , Tan Barrie Yau Boon , Tan Vanessa Yee Jueen 
Published: August 2023

Abstract

Introduction:
A retrospective study (2011 to 2018) was conducted to evaluate the management of cholesteatomas with labyrinthine fistulae (LFs), clinical characteristics and postoperative hearing outcomes in a hospital.

Methods:
Demographic data of patients with primary middle ear mastoidectomies for cholesteatoma were extracted. Preoperative high-resolution computed tomography (HRCT) temporal bone and intraoperative findings, and hearing levels preoperatively and postoperatively were evaluated.

Results:
Of the middle ear cholesteatomas, 15.6% (n = 14) of ears were complicated by LF. HRCT scans showed 92.9% sensitivity and 94.7% specificity in the identification of LFs. Intraoperative findings of LFs include stapes erosion (78.6%), malleus erosion (78.6%), incus erosion (92.9%), dehiscence of tegmen tympani (28.6%) and tympanic facial canal (64.3%). Compared to the non-LF group, the LF group showed significantly higher incidence of stapes erosion (P < 0.001), tegmen tympani dehiscence (P = 0.016) and semicircular canal dehiscence (P < 0.001). Matrix was removed completely in 85.7% (n = 12) and was left behind in 14.3% (n = 2) of ears. Also, 21.5% (n = 3) had preoperative dead ears. Postoperative hearing results had a mean follow-up time of 2.1 (standard deviation 1.5, range 0.14–4.84) years. In the matrix removal group (n = 9), 77.9% had unchanged hearing levels, 11.1% showed improvement and 11.1% showed decrease in hearing levels. The matrix preservation group (n = 2) had deteriorated hearing levels.

Conclusion:
Preservation of hearing in LFs is possible with cautious matrix removal. Despite matrix preservation to preserve hearing in large LFs, our patients’ hearing deteriorated postoperatively. Longer follow-up of hearing with matrix preservation may show poorer hearing outcomes.
Moderasi Beragama: Upaya Guru Pendidikan Agama Kristen Mencegah Sikap Intoleran Pada Remaja
Authors: Meniria laoli  , Zai Leo Swastani , Marampa Elieser R , Undras Indraldo 
Published: August 2023

Intoleran adalah sikap menentang perbedaan antar sesama manusia. Sikap intoleran ini dapat menghambat kesejahteraan hidup berbangsa dan bernegara yang ditandai dengan munculnya berbagai pertikaian antar umat beragama dan antar budaya yang terjadi dalam lingkungan masyarakat maupun lingkungan pendidikan. Oleh karena itu, peneliti tertarik mengkaji sejauh mana upaya guru Pendidikan Agama Kristen mencegah sikap intoleran melalui penanaman pemahaman moderasi beragama. Dalam penelitian ini peneliti menggunakan metode pendekatan kualitatif dengan studi pustaka (library research) yaitu mengutip penelitian terdahulu dari berbagai sumber antara lain artikel jurnal, buku, dan pdf yang menjadi pendukung dalam penulisan artikel ini. Hasil dari analisis upaya guru pendidikan agama kristen mencegah sikap intoleransi pada anak remaja melalui penanaman pemahaman moderasi beragama sebagai mata pelajaran yang disampaikan oleh guru PAK dengan harapan mampu menumbuhkan sikap menghargai perbedaan baik dari segi agama, ras, suku, antar golongan, budaya dan tingkat perekonomian, mencintai bangsa dengan segenap hati, tidak menjatuhkan satu sama lain dan hidup sebagai masyarakat yang demokratis.
Manifestaciones físico-conductuales del neuro-desbalance hormonal en mujeres con síndrome de ovario poliquístico
Authors: Ruiz Zamora Linda Sofía 
Published: August 2023

PROBLEMA: manifestaciones físico-conductuales del neuro-desbalance hormonal en mujeres con síndrome de ovario poliquístico. OBJETIVO: analizar la frecuencia de la aparición de manifestaciones físico-conductuales propias del neuro-desbalance hormonal del síndrome de ovario poliquístico en mujeres en edad fértil. MÉTODO: se realizó un estudio descriptivo transversal con enfoque de investigación cualitativa, método inductivo y técnica de entrevista e instrumentos de boleta de recolección de datos y guía de entrevista con 88 mujeres con síndrome de ovario poliquístico a nivel Guatemala y Latinoamérica. RESULTADOS: se demostró que el rango etario de mujeres con síndrome de ovario poliquístico más frecuente fue de 21 a 25 años con un 34.10% (N=88), encontrando múltiples manifestaciones físico-conductuales del neuro-desbalance hormonal como alteraciones en el ciclo menstrual en un 84% de incidencia, acompañado de quistes en los ovarios con el 81%, rostro con piel grasa o mixta con el 67% y el 53.41% con hirsutismo. Estrés en 64% de ellas, 59% sufren ansiedad y 53.41% de depresión, irritabilidad el 52.27%, etc. CONCLUSIÓN: las mujeres con síndrome de ovario poliquístico presentan múltiples manifestaciones físico-conductuales como alopecia, hirsutismo, acné, entre otros.
SIKAP MODERASI BERAGAMA GURU PENDIDIKAN AGAMA ISLAM SEKOLAH DASAR DI KECAMATAN PASAR MINGGU KOTA JAKARTA SELATAN PROVINSI DKI
Authors: Syukur Taufik Abdillah , Mahyudin Mahyudin , Sunardin Sunardin , Lutfi Muhammad Iqbal , Ismatullah Ismatullah 
Published: August 2023

AbstractThe purpose of this study is to reveal the religious moderation attitude of Islamic Religious Education teachers at the elementary school level in the Pasar Minggu neighborhood of Jakarta. This study used a mixed method. From the results of this study, it was revealed that the majority of these teachers are still not moderate in religion. The implication of this study is that the central and local governments, in this case, the Ministry of Religious Affairs must continue to strive so that religious moderation continues to be improved for teachers both through seminars and training, so that later teachers are able to act as religious moderation educators for their students.AbstrakTujuan penelitian ini adalah untuk mengungkap sikap moderasi beragama guru Pendidikan Agama Islam pada tingkat Sekolah Dasar di lingkungan Pasar Minggu Jakarta. Penelitian ini menggunakan metode campuran. Dari hasil penelitian ini terungkap bahwa para guru tersebut mayoritas masih belum bersikap moderat dalam beragama. Implikasi dari penelitian ini bahwa pemerintah pusat maupun daerah dalam hal ini kementrian Agama harus terus berupaya agar moderasi beragama ini terus ditingkatkan bagi para guru baik melalui seminar maupun pelatihan, sehingga nantinya guru mampu memerankan diri menjadi pendidik moderasi beragama bagi siswanya.
Sistem Informasi Repository Berbasis Web Fakultas Keguruan dan Ilmu Pendidikan Universitas Muhammadiyah Palembang Dengan Menggunakan Framework Codeigniter
Authors: Syahril Muhammad , Andryansyah Muhammad 
Published: August 2023

The Repository Information System Is Implemented In Order To Create The Needs Needed By The Faculty Of Teacher Training And Education. Therefore, the Repository Information System must be implemented by the Faculty of Teacher Training and Education to support accreditation to become a high-impacted faculty.The purpose of this research is to help one of the governance systems in the teaching and education faculties, especially in the field of scientific writing or libraries, the author creates a WEB-based Repository Information System for the Teaching and Education Faculty, University of Muhammadiyah Palembang using the Codeigniter Framework (PHP).The Data Collection Method Is Observation, Literature Study To Determine What Is Needed In Making The Repository Information System.

Keywords: Repository, Scientific Writing, Library, Faculty of Teacher Training and Education, University of Muhammadiyah Palembang
Análisis del desempleo y su afectación a las condiciones de vida de los ecuatorianos, 2019-2021
Authors: SALINAS CAMPUZANO DAVIS XAVIER , Sotomayor Pereira Jorge Guido , Vega Jaramillo Flor Yelena 
Published: August 2023

El objetivo de esta investigación es identificar cómo el desempleo afectó las condiciones de vida de los ecuatorianos durante el periodo 2019-2021. En este sentido, se analiza el comportamiento y variaciones de este fenómeno durante los 3 años de estudio, además de otros indicadores como el consumo, la pobreza y la inversión. También se examina el número de empresas y empleos perdidos durante el 2020, tomando como referencia los 6 principales sectores que son servicios, comercio, agricultura-ganadería-silvicultura y pesca, industrias manufactureras, construcción y explotación de minas y canteras. Para ello se aplica una metodología documental utilizando datos estadísticos del Instituto Nacional de Estadística y Censos y del Banco Central, así como un enfoque descriptivo que permite explicar el comportamiento del objeto de estudio. Los métodos utilizados son histórico-lógico y analítico-sintético para la fundamentación teórica.
Los resultados de la investigación demuestran la caída de la inversión en un -19,0%, aumento del desempleo en 4,9%, incremento de pobreza por ingresos en 33,0%, caída del empleo nacional a 95,1%, disminución del consumo en -8,2% y aumento del desempleo juvenil en 10,3%. Los 3 sectores más afectados en el 2020 fueron el de servicios con 17.366 empresas cerradas, comercio con 8.596 y la industria manufacturera con 3.816 empresas inhabilitadas. Finalmente se concluye que las alternativas de solución para disminuir el desempleo giran en torno al incentivo de la inversión mediante un marco tributario amigable y la flexibilización laboral.
The Earlie King and The Kid in Yellow: uma versão pós-apocalíptica da Irlanda
Authors: Ferreira Rejane de Souza 
Published: August 2023

The Earlie King & The Kid in Yellow (2018), de Danny Denton, narra o mito da destruição da Irlanda através do fogo e o colapso digital após o país enfrentar anos de chuvas ininterruptas causadas pela catástrofe ambiental deixada principalmente pela indústria farmacêutica. O propósito deste artigo é investigar como essa obra coaduna e desafia ao mesmo tempo a tradição ecocrítica e distópica produzida na língua inglesa dos centros hegemônicos e a tradição literária de seu próprio país. Para tanto eu utilizo quatro divisões didáticas: 1) breve resumo de como o Antropoceno tem sido representado na literatura de língua inglesa; 2) a contribuição da distopia para representação das alterações climáticas na literatura; 3) panorama histórico da literatura da Irlanda e 4) contextualização da obra de Denton em análise. Nesta última parte, arremato com a observação de que o romance não propõe alternativa para solucionar os problemas do Antropoceno, mas alerta para o colapso que estamos na iminência de vivenciar
Rancang Bangun Game Edukasi Sebagai Media Pengenalan Rambu Lalu Lintas Berbasis Android
Authors: Linda Linda , Hidayati Awanis , Maulana Adha 
Published: August 2023

Tujuan penelitian ini adalah menghasilkan sebuah game yang dapat mengedukasikan anak tentang mengenal rambu lalu lintas. Adapun metode penelitian yang digunakan pada penelitian ini adalah metode pengembangan R&D (Research and Development), metode penelitian dan pengembangan merupakan metode penelitian yang digunakan untuk menghasilkan sebuah produk tertentu dan menguji keefektifan produk tersebut. Model pengembangan pada penelitian ini menggunakan model pengembangan prototype, dan tahapan prototype mulai dari analisis kebutuhan, desain, dan implementasi. Pengujian penelitian ini menggunakan tiga pengujian yaitu pengujian black box, alpha, dan beta, dengan menggunakan aspek functionality, efficiency, dan usability. Pengujian ini dilakukan untuk menilai kelayakan game “PRANTAS” (Pengenalan Rambu Lalu Lintas) berbasis Android, pengenalan rambu lalu lintas yang diberikan kepada responden yaitu rambu perintah, peringatan, petunjuk, dan larangan. Hasil penelitian media game edukasi ini adalah dari semua aspek perhitungan alpha 92% dengan kategori sangat layak digunakan, sedangkan perhitungan semua aspek perhitungan beta 96% dengan kategori sangat layak digunakan.
Comparison Of The Effects Of Andız (Juniperus sp) Root Extract And Vitamin B12 On Nerve Healing in Rats With Sciatic Nerve Injury
Authors: SANCAK Tunahan , ÇETİN Eyüp 
Published: August 2023

The self-repair capacity of peripheral nerves is limited, and the repair of severely damaged or significantly flawed nerves is challenging. For preclinical investigations on peripheral nerve regeneration, the sciatic nerve injury model is the most often used experimental model. In rats, sciatic nerve injury is the most frequently used model in studies related to peripheral nerve regeneration.
Material and Methods: In this study, 32 rats were subjected to sciatic nerve injury, and applications of B12 vitamin and Andız root extract were performed. After the applications, the rats were sacrificed on the 21st day, and samples of the sciatic nerve tissue were taken. The collected samples were examined using histopathological and immunofluorescence methods.
Results: The examination revealed that B12 vitamin and Andız root extract, when applied separately to the rats, provided limited and similar benefits histopathologically, while the group that received combined treatment showed more effective positive effects compared to all other groups. Additionally, when assessing S100 and GFAP expression through immunofluorescence, it was observed that individual applications provided similar benefits, while the group that received combined treatment contributed more effectively compared to all other groups.
Conclusion: In conclusion, in the rat model of sciatic nerve injury, it was determined that Andız root extract and B12 vitamin, when applied separately, had limited and similar effects compared to the control group in determining the levels of recovery. However, when applied together, they exhibited a synergistic effect, providing a greater contribution to nerve regeneration compared to all other groups.