bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cathepsin S inhibition in dendritic cells prevents Th17 cell differentiation in perivascular adipose tissues following vascular injury in diabetic rats
Authors: Peng Hongyu , Lv Yuan , Li Changjiang , Cheng Zichao , He Songyuan , Wang Cong , Liu Jinghua 
Published: June 2023

AbstractIn the context of diabetes mellitus (DM), the circulating cathepsin S (CTSS) level is significantly higher in the cardiovascular disease group. Therefore, this study was designed to investigate the role of CTSS in restenosis following carotid injury in diabetic rats. To induce DM, 60 mg/kg of streptozotocin (STZ) in citrate buffer was injected intraperitoneally into Sprague‐Dawley rats. After successful modeling of DM, wire injury of the rat carotid artery was performed, followed by adenovirus transduction. Levels of blood glucose and Th17 cell surface antigens including ROR‐γt, IL‐17A, IL‐17F, IL‐22, and IL‐23 in perivascular adipose tissues (PVAT) were evaluated. For in vitro analysis, human dendritic cells (DCs) were treated with 5.6−25 mM glucose for 24 h. The morphology of DCs was observed using an optical microscope. CD4+T cells derived from human peripheral blood mononuclear cells were cocultured with DCs for 5 days. Levels of IL‐6, CTSS, ROR‐γt, IL‐17A, IL‐17F, IL‐22 and IL‐23 were measured. Flow cytometry was conducted to detect DC surface biomarkers (CD1a, CD83, and CD86) and Th17 cell differentiation. The collected DCs presented a treelike shape and were positive for CD1a, CD83, and CD86. Glucose impaired DC viability at the dose of 35 mM. Glucose treatment led to an increase in CTSS and IL‐6 expression in DCs. Glucose‐treated DCs promoted the differentiation of Th17 cells. CTSS depletion downregulated IL‐6 expression and inhibited Th17 cell differentiation in vitro and in vivo. CTSS inhibition in DCs inhibits Th17 cell differentiation in PVAT tissues from diabetic rats following vascular injury.
A symptom network model of misophonia: From heightened sensory sensitivity to clinical comorbidity
Authors: Andermane Nora , Bauer Mathilde , Simner Julia , Ward Jamie 
Published: June 2023

AbstractObjectivesMisophonia—an unusually strong intolerance of certain sounds—can cause significant distress and disruption to those who have it but is an enigma in terms of our scientific understanding. A key challenge for explaining misophonia is that, as with other disorders, it is likely to emerge from an interaction of traits that also occur in the general population (e.g., sensory sensitivity and anxiety) and that are transdiagnostic in nature (i.e., shared with other disorders).MethodsIn this preregistered study with a large sample of participants (N = 1430), we performed a cluster analysis (based on responses to questions relating to misophonia) and identified two misophonia subgroups differing in severity, as well as a third group without misophonia. A subset of this sample (N = 419) then completed a battery of measures designed to assess sensory sensitivity and clinical comorbidities.ResultsClinical symptoms were limited to the most severe group of misophonics (including autistic traits, migraine with visual aura, anxiety sensitivity, obsessive‐compulsive traits). Both the moderate and severe groups showed elevated attention‐to‐detail and hypersensitivity (across multiple senses). A novel symptom network model of the data shows the presence of a central hub linking misophonia to sensory sensitivity which, in turn, connects to other symptoms in the network (relating to autism, anxiety, etc.).ConclusionThe core features of misophonia are sensory‐attentional in nature with severity linked strongly to comorbidities.
Comparison of survival for metastatic pancreatic cancer patients treated with CPI‐613 versus resected borderline‐resectable pancreatic cancer patients
Authors: Mangieri Christopher W. , Valenzuela Cristian D. , Solsky Ian B. , Erali Richard A. , Pardee Timothy , Lima Caio Max S. Rocha , Howerton Russell , Clark Clancy J. , Shen Perry 
Published: June 2023

AbstractIntroductionTreatment of advanced pancreatic adenocarcinoma remains suboptimal. Therapeutic agents with a novel mechanism of action are desperately needed; one such novel agent is CPI‐613 targets. We here analyze the outcomes of 20 metastatic pancreatic cancer patients treated with CPI‐613 and FOLFIRINOX in our institution and evaluate their outcomes to borderline‐resectable patients treated with curative surgery.MethodsA post hoc analysis was performed of the phase I CPI‐613 trial data (NCT03504423) comparing survival outcomes to borderline‐resectable cases treated with curative resection at the same institution. Survival was measured by overall survival (OS) for all study cases and disease‐free survival (DFS) for resected cases with progression‐free survival for CPI‐613 cases.ResultsThere were 20 patients in the CPI‐613 cohort and 60 patients in the surgical cohort. Median follow‐up times were 441 and 517 days for CPI‐613 and resected cases, respectively. There was no difference in survival times between CPI‐613 and resected cases with a mean OS of 1.8 versus 1.9 year (p = 0.779) and mean PFS/DFS of 1.4 versus 1.7 years (p = 0.512). There was also no difference in 3‐year survival rates for OS (hazard ratio [HR] = 1.063, 95% confidence interval [CI] 0.302–3.744, p = 0.925) or DFS/PFS (HR = 1.462, 95% CI 0.285–7.505, p = 0.648).ConclusionThe first study to evaluate the survival between metastatic patients treated with CPI‐613 versus borderline‐resectable cases undergoing curative resection. Analysis revealed no significant differences in survival outcomes between the cohorts. Study results are suggestive that there may be potential utility with the addition of CPI‐613 to potentially resectable pancreatic adenocarcinoma, although additional research with more comparable study groups are required.
Mixed Hyperbranched/Triblock Copolymer Micelle Assemblies: Physicochemical Properties and Potential for Drug Encapsulation
Authors: Gerardos Angelica Maria , Balafouti Anastasia , Pispas Stergios 
Published: June 2023

AbstractMixed micelles have numerous advantages while requiring little to no effort in preparation. This study aims to produce mixed micelle nanostructures from a linear triblock copolymer and a hyperbranched random copolymer, and is able to be loaded with the weakly water‐soluble drugs curcumin and indomethacin. Different preparation techniques are employed to produce mixed micelles comprised of Pluronic F127 block copolymer, and hyperbranched poly[(ethylene glycol) methyl ether methacrylate‐co‐lauryl methacrylate], H‐[P(OEGMA‐co‐LMA)], copolymer. Few studies have dabbled in these types of coassemblies, which provides insight into how structural differences of each copolymer can affect the formation of micelles. To determine the properties of the emerging nanostructures in aqueous environments, including their size, homogeneity, and surface charge, different physicochemical techniques are used, such as light scattering and spectroscopic methods. The results reveal that the copolymers combine, and spontaneously self‐assemble into mixed micelle‐like nanostructures in aqueous environments, whereas both systems of neat and drug‐loaded nanostructures exhibit desirable properties such as small average micelle hydrodynamic radii and low size polydispersity indices. The nanostructures that result from the effective encapsulation of curcumin exhibit outstanding stability over 169 days. The fluorescent qualities of curcumin persist after encapsulation, making the novel nanostructures excellent candidates for bioimaging applications.
Exponential densities and compound Poisson measures
Authors: Baraniewicz Miłosz , Kaleta Kamil 
Published: June 2023

AbstractWe prove estimates at infinity of convolutions and densities of the corresponding compound Poisson measures for a class of radial decreasing densities on , , which are not convolution equivalent. Existing methods and tools are limited to the situation in which the convolution is comparable to initial density at infinity. We propose a new approach, which allows one to break this barrier. We focus on densities, which are products of exponential functions and smaller order terms—they are common in applications. In the case when the smaller order term is polynomial, estimates are given in terms of the generalized Bessel function. Our results can be seen as the first attempt to understand the intricate asymptotic properties of the compound Poisson and more general infinitely divisible measures constructed for such densities.
Trends in incidence and mortality of acute kidney disease following coronary angiography in Chinese population: 2008–2017
Authors: Li Qiang , Huang Haozhang , Chen Weihua , Shi Shanshan , Lu Xiaozhao , Lai Wenguang , Liang Guoxiao , Wu Jielan , Chen Jiyan , Liu Jin , Chen Shiqun , Wang Amanda Y. , Liu Yong 
Published: June 2023

AbstractBackgroundAcute kidney disease (AKD) has received increasing attention owing to its poor prognosis. However, few studies have investigated the trends in AKD incidence and prognosis among patients undergoing coronary angiography (CAG). Therefore, this study was designed to explore trends in the incidence and mortality of AKD following CAG in China.MethodsWe enrolled patients undergoing CAG using data of the Cardiorenal Improvement (CIN) cohort registry of Guangdong Provincial People's Hospital. Univariate and multivariate logistic regression analyses were applied to examine the incidence of AKD from 2008 to 2017. Mortality rates are presented as deaths per 1000 person‐years and were evaluated in univariate and multivariate Cox regression analyses.ResultsA total of 9665 patients (mean age: 61.6 ± 9.6 years, 40% women) were enrolled in the final analysis. From 2008 to 2017, the overall incidence and mortality of AKD were 19% and 323.0 per 1000 person‐years, respectively. The incidence of AKD decreased from 25% to 13% during 2008–2017 (adjusted odds ratio, 0.40; 95% confidence interval [CI], 0.31–0.51; p < 0.01; p for trend <0.01). However, the mortality of AKD increased significantly from 138.2 to 544.1 per 1000 person‐years (adjusted hazard ratio, 2.85; 95% CI, 1.20–6.73; p = 0.02, p for trend = 0.02). The above trends were observed consistently in patients stratified by sex and age.ConclusionsOur findings suggest a significant decrease in incidence and an increase in mortality of AKD following CAG from 2008 to 2017 in China. We advocate for more proactive measures to prevent AKD and improve the prognosis of patients with AKD.
A mixed methods study using case studies prepared by nursing students as a clinical practice evaluation tool
Authors: Palmar‐Santos Ana María , Oter‐Quintana Cristina , Olmos Ricardo , Pedraz‐Marcos Azucena , Robledo‐Martin Juana 
Published: June 2023

AbstractAimTo identify the presence of variability in the evaluation of case studies prepared by nursing students during their primary care rotations based on the existing evaluation rubric. To explore the difficulties experienced by link lecturers and students in preparing and evaluating case studies.DesignA mixed methods study.MethodsThe scores for the rubric items and the final grades for the case studies were collected from a sample of 132 cases. Qualitative information was collected by conducting open‐ended interviews with lecturers and a focus group session with students.ResultsStatistically significant differences were identified between the lecturers' mean final grades [F(5.136) = 3.984, p = 0.002] and a variety of items in the evaluation rubric (p < 0.05). In addition, effect sizes [η2 (≈0.14)] of considerable magnitude were found.Two themes emerged from the qualitative data: (1). the challenge of preparing the case studies and (2). the variable nature of the evaluations.
Stakeholder consensus suggests strategies to promote sustainability in an artisanal fishery with high rates of poaching and marine mammal bycatch
Authors: Svolkinas Linas , Holmes George , Dmitrieva Lilia , Ermolin Ilya , Suvorkov Pavel , Goodman Simon J. 
Published: June 2023

Abstract

Illegal fishing for high value species in artisanal fisheries drives incidental catch and declines of marine mammals and other large vertebrates of conservation importance around the world. Engaging with stakeholders is essential to understand which strategies will be effective in motivating the development of more sustainable practices, and disengagement from illegal fisheries.

Here we present the results of a Q study carried out in autumn 2018 with 50 stakeholders from the Caspian Sea coast of Dagestan (Russian Federation), including fishers illegally targeting sturgeon (Acipenseridae) and Caspian seals Pusa caspica, traders and fisheries managers. We assess viewpoints on biodiversity governance; illegal, unreported and unregulated (IUU) fishing; illegal wildlife trade (IWT) and conservation.

Three distinct viewpoint groups emerged from a factor analysis, which we designated as ‘Nostalgists’, ‘Optimists’ and ‘Pessimists’. Nostalgists were concerned with decline in environmental quality, and emphasised a need for increased centralised involvement of authorities reminiscent of the old Soviet system. Optimists expressed support for a well‐regulated legal fisheries sector, while Pessimists were very aware of the negative impact of illegal fisheries and IWT, but felt they could not be controlled.

Among all groups we found a strong desire for alternative livelihoods (ALs), improved sustainability and agreement on the potential effectiveness of marine protected areas (MPAs) and increased regulation, even if some stakeholders felt they were not achievable goals.

We used our results to inform three workshops in which Dagestani fishers and fishery experts discussed potential conservation interventions, and the barriers to their implementation. Six action types were identified including enhanced law enforcement, increased regulation, protected areas, alternative livelihoods, reducing demand for sturgeon and seal products and the need for further research to guide policy development.

This consensus suggests that communities are willing to reduce participation in illegal fishing given appropriate support. The socioeconomic factors driving illegal fisheries and bycatch for Caspian seals parallel those for other endangered marine mammals such as Vaquita Phocoena sinus and suggest that Q studies could be applied in other artisanal fisheries with high rates of marine mammal bycatch to help identify policy interventions supported by involved communities.

Read the free Plain Language Summary for this article on the Journal blog.
Fiber optics for quantum
Authors: Knigge Anja , Knothe Christian , Kroker Tobias 
Published: June 2023

AbstractTechnical progress in both industry and science has enabled the preparation, manipulation, and probing of quantum systems with an unprecedented level of control. This provides the basis for a multitude of so‐called quantum technologies like quantum cryptography, quantum sensors and quantum computers, which are currently developing from laboratory experiments into commercial applications.
Fastlane to quantum advantage through co‐design
Authors: Rank Stefan , Deppe Frank 
Published: June 2023

AbstractQuantum computers promise to solve certain advanced computational tasks with higher computational speed, higher accuracy, and less energy consumption. To be useful for real‐world applications, traditional quantum algorithms typically require significantly more sophisticated quantum computers than are available today.Co‐designing application‐specific quantum integrated circuits (ASICs) is one avenue being explored by quantum computing scientists and engineers to achieve quantum advantage in the near future. Currently, the co‐design paradigm is most prominently pursued in the field of superconducting quantum systems, which operate in the microwave regime.Nevertheless, due to the universality of the underlying light‐matter coupling mechanisms, insights taken from the field of photonics could provide valuable contributions to the advancement of co‐designed quantum computers.
Micromachining gains from simulation
Authors: Wagner Jan , Schlüter Holger 
Published: June 2023

AbstractDeveloping laser processes for industrial applications is a challenging and laborious task. Conventional controllers for laser scan systems lack the ability to predict the actual path of the laser beam on the workpiece, making extensive trial‐and‐error testing of different parameters and delay settings necessary in order to achieve satisfactory results. Finding a balance between the accuracy achieved and throughput is typically a compromise, and varies from user to user. Thanks to the introduction of SCANmotionControl, a new software solution by Scanlab, the programming of laser processes has been revolutionized.
Construction of CpG Delivery Nanoplatforms by Functionalized MoS2 Nanosheets for Boosting Antitumor Immunity in Head and Neck Squamous Cell Carcinoma
Authors: Li Hongxia , Liu Ming , Zhang Shuaiyin , Xie Xinran , Zhu Yuefei , Liu Tianrun , Li Jian , Tu Zhaoxu , Wen Weiping 
Published: June 2023

AbstractDespite the promising achievements of immune checkpoint blockade (ICB) therapy for tumor treatment, its therapeutic effect against solid tumors is limited due to the suppressed tumor immune microenvironment (TIME). Herein, a series of polyethyleneimine (Mw = 0.8k, PEI0.8k)‐covered MoS2 nanosheets with different sizes and charge densities are synthesized, and the CpG, a toll‐like receptor‐9 agonist, is enveloped to construct nanoplatforms for the treatment of head and neck squamous cell carcinoma (HNSCC). It is proved that functionalized nanosheets with medium size display similar CpG loading capacity regardless of low or high PEI0.8k coverage owing to the flexibility and crimpability of 2D backbone. CpG‐loaded nanosheets with medium size and low charge density (CpG@MM‐PL) could promote the maturation, antigen‐presenting capacity, and proinflammatory cytokines generation of bone marrow‐derived dendritic cells (DCs). Further analysis reveals that CpG@MM‐PL effectively boosts the TIME of HNSCC in vivo including DC maturation and cytotoxic T lymphocyte infiltration. Most importantly, the combination of CpG@MM‐PL and ICB agents anti‐programmed death 1 hugely improves the tumor therapeutic effect, inspiring more attempts for cancer immunotherapy. In addition, this work uncovers a pivotal feature of the 2D sheet‐like materials in nanomedicine development, which should be considered for the design of future nanosheet‐based therapeutic nanoplatforms.
Embedding Nano‐Piezoelectrics into Heterointerfaces of S‐Scheme Heterojunctions for Boosting Photocatalysis and Piezophotocatalysis
Authors: Wang Shihong , Li Zengrong , Yang Guodong , Xu Yanbo , Zheng Yiyi , Zhong Shuxian , Zhao Yuling , Bai Song 
Published: June 2023

AbstractStep‐scheme (S‐scheme) heterojunctions have exhibited great potential in photocatalysis due to their extraordinary light harvesting and high redox capacities. However, inadequate S‐scheme recombination of useless carriers in weak redox abilities increases the probability of their recombination with useful ones in strong redox capabilities. Herein, a versatile protocol is demonstrated to overcome this impediment based on the insertion of nano‐piezoelectrics into the heterointerfaces of S‐scheme heterojunctions. Under light excitation, the piezoelectric inserter promotes interfacial charge transfer and produces additional photocarriers to recombine with useless electrons and holes, ensuring a more thorough separation of powerful ones for CO2 reduction and H2O oxidation. When introducing extra ultrasonic vibration, a piezoelectric polarization field is established, which allows efficient separation of charges generated by the embedded piezoelectrics and expedites their recombination with weak carriers, further increasing the number of strong ones participating in the redox reactions. Encouraged by the greatly improved charge utilization, significantly enhanced photocatalytic and piezophotocatalytic activities in CH4, CO, and O2 production are achieved by the designed stacked catalyst. This work highlights the importance in strengthening the necessary charge recombination in S‐scheme heterojunctions and presents an efficient and novel strategy to synergize photocatalysis and piezocatalysis for renewable fuels and value‐added chemicals production.
Carboxylated Poly (p‐Phenylene Terephthalamide) Reinforced Polyetherimide for High‐Temperature Dielectric Energy Storage
Authors: Yan Jingjing , Wang Huan , Zeng Junyang , Zhang Xin , Nan Ce‐Wen , Zhang Shujun 
Published: June 2023

AbstractDielectric energy storage polymers play a vital role in advanced electronics and electrical systems, due to their high breakdown strength, excellent reliability, and easy fabrication. However, the low dielectric constant and poor thermal resistance of dielectric polymers limit their energy storage density and working temperatures, making them less versatile for broader applications. In this work, a novel carboxylated poly (p‐phenylene terephthalamide) (c‐PPTA) is synthesized and employed to simultaneously enhance the dielectric constant and thermal resistance of polyetherimide (PEI), leading to a discharged energy density of 6.4 J cm−3 at 150 °C. The introduction of c‐PPTA molecules effectively reduces the ΠΠ stacking effect and increases the average chain spacing between polymer molecules, which is conducive to improving the dielectric constant. Additionally, c‐PPTA molecules with stronger positive charges and high dipole moments can capture electrons, resulting in reduced conduction loss and enhanced breakdown strength at high temperatures. The coiled capacitor fabricated with the PEI/c‐PPTA film exhibits superior capacitance performances and higher working temperatures compared to commercial metalized PP capacitors, demonstrating great potential for dielectric polymers in high‐temperature electronic and electrical energy storage systems.
Fracture Initiation
Authors: Zhao Yu , Zhang Yongfa , He Pengfei 
Published: June 2023

AbstractField in-situ constant-flow hydraulic fracturing test is an important technique to determine the tectonic stress field. Classical hydraulic fracturing mechanics regards the maximum tensile stress criterion as the critical initiation condition, which assumes that the hydraulic fracture initiates and expands when the maximum effective tangential stress around the wellbore is larger than the tensile strength of the rock, resulting in tensile failure of the rock.
Formation of Complex Networks
Authors: Zhao Yu , Zhang Yongfa , He Pengfei 
Published: June 2023

AbstractWhen a hydraulic fracture interacts with multiple natural fractures (such as bedding planes, faults, weak interlayers, and formation interfaces) in the formation, arrests, bifurcations, crossings, and openings may occur, contributing to forming a complex fracture network (referred as CFN). Shale differs from other types of rocks due to its apparent bedding anisotropy, making it easier to form complex fracture networks during hydraulic fracturing. A mass of field hydraulic fracturing data and laboratory studies have confirmed that the hydraulic fractures generated in shale reservoirs are not bi-wing planar fractures in homogeneous media, but multi-dimensional, asymmetric, and non-planar complex hydraulic fractures (as shown in Fig. 9.1) (Liu et al. in Guti Lixue Xuebao/Acta Mech Solida Sin 37:34–49, 2016; Xiao in Research of hydraulic fracturing dynamic propagation in fractured reservoirs, 2014; Guo and Wang in J Eng Geol 26:118–128, 2016).