bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pretreatment serum monocyte chemoattractant protein‐1 as a predictor of long‐term outcome by ustekinumab in patients with Crohn's disease
Authors: Okuda Hiroaki , Hosomi Shuhei , Itani Shigehiro , Kurimoto Noriyuki , Kobayashi Yumie , Nakata Rieko , Nishida Yu , Ominami Masaki , Nadatani Yuji , Fukunaga Shusei , Otani Koji , Kamata Noriko , Tanaka Fumio , Nagami Yasuaki , Taira Koichi , Ohfuji Satoko , Fujiwara Yasuhiro 
Published: February 2023

AbstractBackground and AimsUstekinumab has been proven to be effective for treatment of patients with Crohn's disease; however, 30–40% of patients have been reported to lose clinical response within 2 years. We aimed to evaluate the efficacy of ustekinumab and identify predictors of short‐term and long‐term efficacy in Crohn's disease.MethodsPatients with Crohn's disease receiving their first ustekinumab infusion in our hospital between June 2017 and September 2020 were prospectively enrolled. Concentrations of serum cytokines and chemokines were measured using a multiplex bead array assay.ResultsFifty‐nine Crohn's disease patients were enrolled in this study. Among 34 clinically active patients, 38.2% achieved a clinical response at week 8. None of the assayed factors were associated with short‐term clinical response. Cumulative persistence rates of ustekinumab were 77.6% at 1 year and 58.9% at 2 years. Univariate Cox regression analysis revealed that Harvey–Bradshaw Index scores at baseline, concomitant immunomodulator treatment, and concentrations of interferon gamma‐induced protein‐10, monocyte chemoattractant protein‐1 (MCP‐1), and interleukin (IL)‐1RA, IL‐4, IL‐6, and IL‐8 were significantly associated with loss of efficacy. Multivariate Cox regression analysis found that biologic naïve status (hazard ratio [HR]: 0.1191, 95% confidence interval [CI]: 0.02458–0.5774) and MCP‐1 concentrations (HR: 1.038, 95% CI: 1.015–1.062) were significantly and associated with loss of sustained efficacy for ustekinumab treatment.ConclusionsOur findings suggest that pretreatment serum MCP‐1 analysis, combined with a history of biologic use, could be a novel biomarker for predicting the long‐term efficacy of ustekinumab in patients with Crohn's disease.
Nutritional status at hospital admission and prediction of clinical outcomes in children and adolescents with cancer: Results of the Brazilian survey on oncological nutrition in paediatrics
Authors: Afonso Wanélia Vieira , Peres Wilza Arantes Ferreira , de Pinho Nivaldo Barroso , Corrêa Schilithz Arthur Orlando , Martucci Renata Brum , Rodrigues Viviane Dias , Braga Juliana Silva do Nascimento , Costa Joana Dias da , Padilha Patricia de Carvalho 
Published: February 2023

AbstractBackgroundChanges in nutritional status are recognised as predictors of unfavourable outcomes in children and adolescents with cancer, particularly in developing countries. There have been no studies on children and adolescents with cancer from every region of Brazil or on the impact of nutritional status on clinical outcomes. The aim of this study is to assess the association between the nutritional status of children and adolescents with cancer and the prediction of clinical outcomes.MethodsThis was a longitudinal, multicentre, hospital‐based study. An anthropometric nutritional assessment was performed, and the Subjective Global Nutritional Assessment (SGNA) was administered within 48 h of admission. Seven hundred and twenty‐three patients (aged 2–18 years) were included in the sample, undergoing cancer treatment. They were recruited in 13 reference centres in the five macro‐regions of Brazil between March 2018 and August 2019. The outcomes evaluated were readmission within 30 days and death within 60 days of admission. To identify predictors of 60‐day survival, Cox regression and log‐rank statistics were used to compare Kaplan–Meier curves between the strata.ResultsAbout 36.2% (n = 262) of the samples were malnourished according to the SGNA. Severe malnutrition by the SGNA (relative risk [RR] = 8.44, 95% confidence interval [CI]: 3.35–21.3, P = 0.001) and living in the North region (RR = 11.9, 95% CI: 3.34–42.7, P = 0.001) were associated with the poorest survival. The North (RR = 5.77, 95% CI: 1.29–25.8, P = 0.021), Northeast (RR = 1.46, 95% CI: 1.01–2.11, P = 0.041), Midwest (RR = 0.43, 95% CI: 0.20–0.095, P = 0.036), age group 10–18 years (RR = 0.65, 95% CI: 0.45– 0.94, P = 0.022) and haematologic malignancy (RR = 1.52, 95% CI: 1.10–2.10, P = 0.011) were predictors of readmission within 30 days.ConclusionsThe prevalence of malnutrition was high and related to death. These results highlight the need to use the SGNA in clinical practice alongside classic anthropometric methods for the diagnosis of malnutrition, and the need to standardise care across all Brazilian regions, which should include nutritional care for children and adolescents with cancer.
Effects of person‐centred planning and practices on the health and well‐being of adults with intellectual and developmental disabilities: a multilevel analysis of linked administrative and survey data
Authors: İsvan N. , Bonardi A. , Hiersteiner D. 
Published: February 2023

AbstractBackgroundA person‐centred service planning and practice approach (PCP) is one that is driven by service users' individual preferences, needs and priorities. The approach has been identified as a best practice and is codified in US policies that encourage and, in some contexts, require state systems of home and community‐based services to adopt and demonstrate person‐centred practice. However, there is insufficient research on PCP's direct impact on outcomes for service users. This study aims to contribute to the evidence base in this area by investigating the association between service experiences and outcomes of adults with intellectual and developmental disabilities (IDD) receiving state‐funded services.MethodsThe data for the study come from the 2018–2019 National Core Indicators® In‐Person Survey that links survey responses with administrative records for a sample of 22 000 adults with IDD receiving services from 37 state developmental disabilities (DD) systems. Associations among service experiences and outcomes of survey participants are examined through multilevel regression techniques that include participant‐level responses and state‐level measures of PCP. The state‐level measures are constructed by combining administrative records describing participants' service plans with the priorities and goals they expressed in response to the survey.ResultsCase managers' (CM) accessibility and attentiveness to individual preferences, as reported by survey participants, are significantly associated with self‐reported outcomes such as perceived control over life decisions and sense of health and well‐being. Controlling for participants' experiences with their CMs, their reports of the person‐centred content of their service plans have net positive associations with outcomes. After accounting for experiences with the service system as reported by participants, the state system's person‐centred orientation, measured by the extent to which service plans across the state reflect participants' wishes for improving their social connections, remains a significant predictor of participants' sense of control over their daily lives.ConclusionsThis study contributes to the evidence base supporting PCP as a service model by identifying pathways that link person‐centred service planning and delivery and person‐centred orientation of state systems to positive outcomes reported by adults with IDD and by demonstrating the value of linking survey and administrative data. The key implication of the findings for policy and practice is that an overall person‐centred orientation of state DD systems as well as PCP training for people who support planning for and delivery of direct supports will substantially improve the lives of adults with IDD.
Psychometric properties of measures designed to assess common mental health problems and wellbeing in adults with intellectual disabilities: a systematic review
Authors: Patel M. , Lee J. Y. , Scior K. 
Published: February 2023

AbstractBackgroundMultiple measures of mental health problems and mental wellbeing for adults with intellectual disabilities are available, but investigations into their reliability and validity are still in the early stages. The aim of this systematic review was to provide an update to previous evaluations of measures of common mental health problems and wellbeing in adults with mild to moderate intellectual disabilities (ID).MethodsA systematic search was performed across three databases (MEDLINE, PsycINFO and SCOPUS). The literature search was limited to the years from 2009 to 2021 and to the original English versions. Ten papers evaluating nine measures were reviewed, and the psychometric properties of these measures were discussed using the Characteristics of Assessment Instructions for Psychiatric Disorders in Persons with Intellectual Developmental Disorders as a framework.ResultsFour measures had at least one rating of ‘good’ across both dimensions of reliability and at least one dimension of validity and were deemed to have promising psychometric properties: the Clinical Outcomes in Routine Evaluation‐Learning Disabilities, Impact of Events Scale‐Intellectual Disabilities, Lancaster and Northgate Trauma Scales and Self‐Assessment and Intervention (self‐report section). Additionally, these measures were developed through consultations with mental health professionals and/or people with IDs and thus were deemed to have good content validity.ConclusionsThis review informs measurement choice for researchers and clinicians while highlighting a need for continued research efforts into the quality of measures available for people with IDs. The results were limited by incomplete psychometric evaluations of measures available. A paucity of psychometrically robust measures of mental wellbeing was observed.
Coupling between GPR143 and dopamine D2 receptor is required for selective potentiation of dopamine D2 receptor function by L‐3,4‐dihydroxyphenylalanine in the dorsal striatum
Authors: Masukawa Daiki , Kitamura Satoshi , Tajika Rei , Uchimura Hiraku , Arai Masami , Takada Yuuki , Arisawa Tetsu , Otaki Momoyo , Kanai Kaori , Kobayashi Kenta , Miyazaki Tomoyuki , Goshima Yoshio 
Published: February 2023

AbstractDopamine (DA) is involved in neurological and physiological functions such as motor control. L‐3,4‐dihydroxyphenylalanine (L‐DOPA), a precursor of DA, is conventionally believed to be an inert amino acid precursor of DA, and its major therapeutic effects in Parkinson's disease (PD) are mediated through its conversion to DA. On the contrary, accumulating evidence suggests that L‐DOPA itself is a neurotransmitter. We here show that L‐DOPA potentiates DA D2 receptor (DRD2) signaling through GPR143, the gene product of X‐linked ocular albinism 1, a G‐protein‐coupled receptor for L‐DOPA. In Gpr143‐gene‐deficient (Gpr143−/y) mice, quinpirole, a DRD2/DRD3 agonist, ‐induced hypolocomotion was attenuated compared to wild‐type (WT) mice. Administration of non‐effective dose of L‐DOPA methyl ester augmented the quinpirole‐induced hypolocomotion in WT mice but not in Gpr143−/y mice. In cells co‐expressing GPR143 and DRD2, L‐DOPA enhanced the interaction between GPR143 and DRD2 and augmented quinpirole‐induced decrease in cAMP levels. This augmentation by L‐DOPA was not observed in cells co‐expressing GPR143 and DRD1 or DRD3. Chimeric analysis in which the domain of GPR143 was replaced with GPR37 revealed that GPR143 interacted with DRD2 at the fifth transmembrane domain. Intracerebroventricular administration of a peptide that disrupted the interaction mitigated quinpirole‐induced behavioral changes in WT mice but not in Gpr143−/y mice. These findings provide evidence that coupling between GPR143 and DRD2 is required for selective DRD2 modulation by L‐DOPA in the dorsal striatum.image
Astrotactin 2 (ASTN2) regulates emotional and cognitive functions by affecting neuronal morphogenesis and monoaminergic systems
Authors: Ito Takahiro , Yoshida Mikio , Aida Tomomi , Kushima Itaru , Hiramatsu Yuka , Ono Maiko , Yoshimi Akira , Tanaka Kohichi , Ozaki Norio , Noda Yukihiro 
Published: February 2023

AbstractAstrotactin2 (ASTN2) regulates neuronal migration and synaptic strength through the trafficking and degradation of surface proteins. Deletion of ASTN2 in copy number variants has been identified in patients with schizophrenia, bipolar disorder, and autism spectrum disorder in copy number variant (CNV) analysis. Disruption of ASTN2 is a risk factor for these neurodevelopmental disorders, including schizophrenia, bipolar disorder, autism spectrum disorder, and attention deficit hyperactivity disorder. However, the importance of ASTN2 in physiological functions remains poorly understood. To elucidate the physiological functions of ASTN2, we investigated whether deficiency of ASTN2 affects cognitive and/or emotional behaviors and neurotransmissions using ASTN2‐deficient mice. Astn2 knockout (KO) mice produced by CRISPR/Cas9 technique showed no obvious differences in physical characteristics and circadian rhythm. Astn2 KO mice showed increased exploratory activity in a novel environment, social behavior and impulsivity, or decreased despair‐, anxiety‐like behaviors and exploratory preference for the novel object. Some behavioral abnormalities, such as increased exploratory activity and impulsivity, or decreased exploratory preference were specifically attenuated by risperidone, but not by haloperidol. While, the both drugs did not affect any emotion‐related behavioral abnormalities in Astn2 KO mice. Dopamine contents were decreased in the striatum, and serotonin or dopamine turnover were increased in the striatum, nucleus accumbens, and amygdala of Astn2 KO mice. In morphological analyses, thinning of neural cell layers in the hippocampus, reduction of neural cell bodies in the prefrontal cortex, and decrease in spine density and PSD95 protein in both tissues were observed in Astn2 KO mice. The present findings suggest that ASTN2 deficiency develops some emotional or cognitive impairments related to monoaminergic dysfunctions and abnormal neuronal morphogenesis with shrinkage of neuronal soma. ASTN2 protein may contribute to the pathogenic mechanism and symptom onset of mental disorders.image
Lifespan normative data (18–89 years) for Raven's Advanced Progressive Matrices Set I
Authors: Murphy Patrick , Foley Jennifer , Mole Joe , Van Harskamp Natasja , Cipolotti Lisa 
Published: February 2023

AbstractRaven's Advanced Progressive Matrices (APM) Set I is a validated and brief test of fluid intelligence, ideal for use in busy clinical settings. However, there is a dearth of normative data allowing an accurate interpretation of APM scores. To address this, we present normative data from across the adult lifespan (18–89 years) for the APM Set I. Data are presented in five age cohorts (total N = 352), including two older adult cohorts (65–79 years and 80–89 years), which allows age‐standardized assessment. We also present data from a validated measure of premorbid intellectual ability, which was absent from previous standardizations of longer forms of the APM. In line with previous findings, a striking age‐related decline was noted, beginning relatively early in adulthood and most marked amongst lower‐scoring individuals. Older adults did not demonstrate difficulty with specific test items or make an increased proportion of specific errors. Sex was not a significant predictor of performance. The data set is of particular use in the neuropsychological assessment of older adults, given the known susceptibility of fluid intelligence to both the effects of normal ageing and acquired brain injury in older age. The results are discussed in light of theories of neurological ageing.
The evaluation of serum bisphenol A in patients with preeclampsia
Authors: Dagdeviren Gulsah , Arslan Burak , Keles Ayse , Yücel Çelik Özge , Arat Özgür , Caglar Ali Turhan 
Published: February 2023

AbstractAimsHigh bisphenol A (BPA) concentration may compromise normal placental development. The aim of this study was to determine maternal serum BPA concentrations in pregnant women with complicated preeclampsia (PE) and normal pregnant women, to compare BPA concentrations, and to examine pregnancy outcomes.MethodsThis prospective case–control study was conducted between March 2021 and October 2021. Serum BPA levels of preeclamptic pregnancy and normal pregnancy were statistically evaluated. In addition, the PE group was divided into three subgroups according to the course of pregnancy. Group 1: patients with non‐severe PE who delivered at 37 weeks or later, Group 2: patients with severe PE who delivered at less than 34 weeks, Group 3: patients with severe PE who delivered between 34 and 37 weeks. The association between BPA levels and pregnancy outcome was investigated.ResultsForty‐six cases in the PE group were compared with 46 cases of normal pregnancies. The median BPA level was 19.46 ng/mL in the PE group and 16.36 ng/mL in the control group. The median BPA levels in the PE group were significantly higher than those in the control group (p = 0.007). Serum BPA levels were significantly lower in women who delivered at 37 weeks or later than in women who delivered at less than 34 weeks due to severe PE (p ≤ 0.018).ConclusionOur study highlights the association between elevated maternal serum levels of BPA and PE. Moreover, knowledge of BPA levels in women with PE may provide information about the prognosis of pregnancy.
Feasibility, efficacy, and functional relevance of automated auditory closed‐loop suppression of slow‐wave sleep in humans
Authors: Fehér Kristoffer D. , Omlin Ximena , Tarokh Leila , Schneider Carlotta L. , Morishima Yosuke , Züst Marc A. , Wunderlin Marina , Koenig Thomas , Hertenstein Elisabeth , Ellenberger Benjamin , Ruch Simon , Schmidig Flavio , Mikutta Christian , Trinca Ersilia , Senn Walter , Feige Bernd , Klöppel Stefan , Nissen Christoph 
Published: February 2023

SummarySlow‐wave sleep (SWS) is a fundamental physiological process, and its modulation is of interest for basic science and clinical applications. However, automatised protocols for the suppression of SWS are lacking. We describe the development of a novel protocol for the automated detection (based on the whole head topography of frontal slow waves) and suppression of SWS (through closed‐loop modulated randomised pulsed noise), and assessed the feasibility, efficacy and functional relevance compared to sham stimulation in 15 healthy young adults in a repeated‐measure sleep laboratory study. Auditory compared to sham stimulation resulted in a highly significant reduction of SWS by 30% without affecting total sleep time. The reduction of SWS was associated with an increase in lighter non‐rapid eye movement sleep and a shift of slow‐wave activity towards the end of the night, indicative of a homeostatic response and functional relevance. Still, cumulative slow‐wave activity across the night was significantly reduced by 23%. Undisturbed sleep led to an evening to morning reduction of wake electroencephalographic theta activity, thought to reflect synaptic downscaling during SWS, while suppression of SWS inhibited this dissipation. We provide evidence for the feasibility, efficacy, and functional relevance of a novel fully automated protocol for SWS suppression based on auditory closed‐loop stimulation. Future work is needed to further test for functional relevance and potential clinical applications.
Persistence of immunity against hepatitis A in Brazilian children vaccinated with a single dose of inactivated virus vaccine
Authors: de Brito Wagner Izidoro , de Oliveira Rode Martinho , Silva Jane , Tubarão Luciana Neves , Bom Ana Paula Dinis Ano , Melgaço Juliana Gil , Pinto Marcelo Alves , Souto Francisco José Dutra 
Published: February 2023

AbstractIn 2014, the Brazilian National Immunization Program implemented the universal vaccination against the hepatitis A virus (HAV) for children aged 12 months and older, applying a single dose of the inactivated virus vaccine. It is essential to carry out follow‐up studies in this population, aiming to verify the longevity of HAV immunological memory. This study evaluated the humoral and cellular immune response of a cohort of children vaccinated between 2014 and 2015, and further investigated between 2015 and 2016, and who had their initial antibody response assessed after the single dose. A second evaluation took place in January 2022. We examined 109 children out of the 252 that took part in the initial cohort. Seventy (64.2%) of them had anti‐HAV IgG antibodies. Cellular immune response assays were performed in 37 anti‐HAV‐negative and 30 anti‐HAV‐positive children. Production of interferon‐gamma (IFN‐y) stimulated with the VP1 antigen was demonstrated in 34.3% of these 67 samples. Of the 37 negative anti‐HAV samples, 12 (32.4%) produced IFN‐y. Among the 30 anti‐HAV‐positive, 11 (36.7%) produced IFN‐y. In total, 82 (76.6%) children presented some type of immune response against HAV. These findings demonstrate the persistence of immunological memory against HAV in the majority of children vaccinated between 6 and 7 years with a single dose of the inactivated virus vaccine.
The infection rates of HBV and HCV decreased significantly in Zhejiang Province, China: A comparative study based on the data of two sero‐epidemiological surveys in 1992 and 2020
Authors: Zhou Yang , Zhao Botao , Shi Wen , Ding Xiaobei , Shen Liping , Zhou Xin , He Hanqing 
Published: February 2023

AbstractIn 2020, China conducted a nationwide, sero‐epidemiological, cross‐sectional survey of viral hepatitis. The stratified multi‐stage cluster random sampling method was used to select the permanent population aged 1–69 years, followed by questionnaire survey and sample collection and detection of the serological markers of hepatitis B (HBV) and hepatitis C viruses (HCV). A total of 4747 individuals aged 1–69 years were investigated in Zhejiang Province. The positive rates of hepatitis B surface antigen and anti‐HCV were 4.3% and 0%, respectively. Compared to a similar sero‐epidemiological survey in 1992, the 2020 survey showed that the HBV infection rate in Zhejiang Province decreased by 56.5%. In both surveys, HBV infection rate increased with age (in 1992, χ2 = 185.866, p = .000; in 2020, χ2 = 1383.836, p = .000). Compared with 1992, the positive anti‐HCV rate in those aged 1–69 years in 2020 decreased by 100.0%. This result showed that the HBV vaccine and blood screening to prevent HBV and HCV infection significantly decreased the infection rate of HBV and HCV in the younger generation of Zhejiang province. However, the rate of HBV carriers aged 30–69 years was still high, which underscores the need to strengthen the management and treatment of chronic HBV infection. Hence, Zhejiang province can eliminate the public health threat of viral hepatitis.