bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical-immunological and neurophysiological correlations in paraneoplastic polyneuropathy caused by small cell lung cancer
Authors: Ponomarev V. V. , Reduto E. V. 
Published: March 2023

Objective. To study the correlation between the neurological, immunological and neurophysiological signs of paraneoplastic polyneuropathy (PPNP) caused by small cell lung cancer (SCLC), to improve the quality of diagnosis of this pathology.Materials and methods. Clinical, immunological (anti-Hu) and neurophysiological (electromyography (EMG), electroneuromyography (ENMG), somatosensory evoked potentials (SSEP)) examination of 61 patients with PPNP caused by SCLC are presented.Results. It was established that sensory disorders in the limbs are the first and obligate clinical symptoms of PPNP, which precede the initial diagnosis of SCLC in 56% in 3-12 months, characterized by a predominance of a decrease in surface sensitivity in the form of distal hypoesthesia in 70% of cases. The motor form is characterized by an older age (67 years) than the sensory (60 years) and sensorimotor (58.0 years, p <0,05). Motor disorders in the limbs occur in 46% of cases, manifested by mild symmetrical distal paresis of the legs and subclinical damage to the motor nerves of the upper extremities according to the results of ENMG (p <0,001). Detection of anti-Hu in plasma is highly correlated with a significant increase in latency and a decrease in amplitudes component N22 in the conduct of SSEP, which indicates the defeat of the axons of the sensory nerves of the limbs (p <0,05). Changes in amplitude parameters, with preserved speed indicators of nerves according to the results of ENMG indicate an axonal type of lesion (p <0,05), which, in combination with the detection of anti-Hu in plasma, are pathognomonic signs of the paraneoplastic nature of the process.Conclusion. As a result of the study, clinical, immunological and neurophysiological features of various forms of PPNP were identified. The obtained correlations make it possible to diagnose the corresponding type of nerve pathology more accurately and in a timely manner and to suspect the development of oncological disease in time. The revealed changes in the indicators of the N22 component of SSEP can serve as a marker of axonal lesion of peripheral nerves, which with high diagnostic efficiency justifies the expediency of inclusion in the protocol of the ENMG study for verification of additional signs characteristic of PPNP.
Surgical anatomy of the intrapelvic branches of the superior gluteal artery in people of a mesohomorphic somatotype
Authors: Kuzmenko A. V. , Zhdanovich V. N. 
Published: March 2023

Objectives. To explore data on branching variants of the intrapelvic part of the superior gluteal artery in people of mesomorphic somatotype.Materials and methods. We used 48 male dead bodies (deceased aged 25 to 82) and 30 female dead bodies (deceased aged 28 to 78) whose deaths were the result of accidental causes unrelated to the pelvic organs pathology. The following methods were used to achieve the goal of the study: vascular injection, dissection, statistical processing.Results. The pattern of localization of anastomotic branches of the intrapelvic part of the superior gluteal artery (SGA) in humans of both sexes of mesomorphic somatotype was established for the first time. In men, 59.1% of all anastomotic branches of the SGA are located in the proximal third, 36.4% of anastomoses are in the middle third of this artery, and 4.5% of arterial connections are in the distal third of a. glutea superior. In women, arterial anastomoses branch from the proximal third of the intrapelvic portion of the SGA in 66.6% of cases and in the middle third of this artery in 33.3% of cases. The SGA in men of mesomorphic somatotype anastomoses more frequently than in women with the same type of build. It was found that intrathecal branches and anastomoses of the SGA in men and women of mesomorphic somatotype are predominantly localized along the proximal two thirds of this artery length. New data were obtained on the number of branches originating from a. glutea superior in the pelvic cavity, such as the lateral sacral artery (LSA), iliac-lumbar artery (ILA), obturator artery (OA), middle rectus, lower ureteric artery and rami musculares of the SGA. The SGA was found to be the most frequent source of lateral sacral artery formation in the pelvic cavity in men and women of mesomorphic somatotype.Conclusions. The patterns of branching of the intrathecal part of the SGA are presented. The results obtained are recommended to be used for endovascular occlusion of the SGA to stop bleeding from the damaged distal third of this artery.
Pathomorphological changes in the organs of laboratory animals with experimental liver cirrhosis
Authors: Evseenko D. A. , Dundarov Z. A. , Nadyrov E. A. 
Published: March 2023

Objective. Develop an experimental model of liver cirrhosis and describe pathomorphological changes in organs and tissues of laboratory animals.Materials and methods. Liver cirrhosis was simulated on 11 sexually mature Wistar male white rats. The control group consisted of 12 healthy laboratory animals. Acute toxic liver injury resulting in cirrhosis was induced by intraperitoneal injection of 50% tetrachloromethane (CCl4) solution on olive oil on the first day of the experiment in the dosage of 0.1 ml CCl4 + 0.4 ml olive oil per 100 g of the animal body weight, on the second day of the experiment 0.3 ml CCl4 + 0.2 ml olive oil per 100 g of the animal body weight. To synergize and potentiate the hepatotoxic effect of CCl4, animals had 10% ethanol solution freely available daily. The duration of the experiment was 65 days. Clinical and laboratory parameters were evaluated, histological evaluation of the preparations was performed. The obtained data were compared with the control group of animals.Results. Reproducibility of the model was 82% (9 animals). The indicator of lymphocyte blabbing index showed the development of liver cirrhosis in animals of the experimental group. Comprehensive morphological confirmation of the developed liver cirrhosis was obtained.Conclusion. The proposed methodology of liver cirrhosis formation correlates with pathomorphological changes in lymphocyte cell wall, changes in liver tissue and internal organs in human liver cirrhosis.
Dystrophic changes in the sciatic nerve: a comparison of ultrasonographic and morphological data (pilot study)
Authors: Yurkovskiy A. M. , Pismennikova E. I. , Achinovich S. L. 
Published: March 2023

Objective. To study the possibility of using ultrasonography to identify mild (early), moderately severe and significantly severe dystrophic changes in the sciatic nerve.Materials and methods. To achieve this goal, we compared ultrasonographic and histological data from 15 pairs of sciatic nerves taken from 8 men and 7 women aged 58 (52; 68) years who had been treated for different oncological diseases and died in 2022 from the underlying disease.Results. Parallelism was revealed between the ultrasonographic pattern in mild, moderately severe and significantly severe dystrophic changes of the sciatic nerve, on the one hand, and the histological and immunohistochemical patterns, on the other hand.Conclusion: Ultrasonography (B-mode) allows identifying mild, moderately severe and significantly severe dystrophic changes of the sciatic nerve.
Biogenic synthesis of selenium nanoparticles using Hibiscus esculentus L. extract: Catalytic degradation of organic dye and its anticancer, antibacterial and antifungal activities
Authors: Ebrahimzadeh Mohammad Ali , Moradsomarein Mina , Lalerdi Fatemeh Sadeghi , Alizadeh Seyedeh Roya 
Published: March 2023

In this work, we develop the synthesis of selenium nanoparticles (B@SeNPs) using a green method using the aqueous extract of Hibiscus esculentus L. Various techniques were used to characterize bio-synthesized B@SeNPs. The mixture color was clearly changed to reddish at 45-50 °C and the extract pH = 6. According to Fourier transform infrared spectroscopy (FT-IR), the B@SeNPs were produced, capped, and stabilized using biomolecules found in plant extracts. The energy dispersive X-ray (EDX) analysis profile revealed an atomic Se signal (1.39 mV). The powder X-ray diffraction (PXRD) pattern confirmed the hexagonal phase crystalline form of B@SeNPs. The zeta potential for SeNPs was determined to be -51.3 mV. Scanning electron microscope (SEM) and transmission electron microscopy (TEM) micrographs revealed spherical Se particles with sizes of roughly 62 nm. Furthermore, B@SeNPs can degrade methylene blue dye by 98.3% at 21 min with a rate constant of 0.1023 min-1 in the presence of NaBH4. In biological evaluation, the synthesized nanoparticles have been proven to be effective against two human cancers (AGS and MCF-7 cells) with IC50 values of 20.46 and 88.43 µg/mL, respectively. Additionally, B@SeNPs showed high safety in the Beas cell line (normal) at 123 µg/mL as the highest concentration. The biofabricated SeNPs had a moderate antibacterial effect against ATCC and multidrug-resistant clinical isolates. They had no antifungal activity against the tested fungus strains except C. albicans (IFRC 1873), with a MIC value of 138.75 µg/mL. Finally, the green-synthesized B@SeNPs could be a contender for further testing as a chemotherapeutic agent in the treatment of some human cancers.
Synthesis, crystal structure, DFT/HF, Hirshfeld surface, and molecular docking analysis of 4-(tert-butyl)-4-nitro-1,1-biphenyl
Authors: Kumari Neha , Sharma Ruchika , Yadav Archana Akaram , Sankpal Sandeep Ashok , Raj Jayakumar Mohan , Murugavel Saminathan , Kant Rajni 
Published: March 2023

4-(tert-Butyl)-4-nitro-1,1-biphenyl has been synthesized, and its structure has been characterized by using some spectroscopic and single-crystal X-ray diffraction techniques. It crystallizes in a monoclinic crystal system with space group P21/n and unit cell parameters: a = 6.4478(3) Å, b = 9.2477(4) Å, c = 23.4572(9) Å, β = 95.114(4)°, V = 1393.11(10) Å3, Z = 4. The molecular structure has been solved by using the intrinsic phasing method. The crystal structure is stabilized by C-H···O interactions. Computational studies were performed using density functional theory (DFT) and Hartree-Fock (HF) methods. The optimized geometry obtained from DFT and HF in the gas phase was compared with solid-phase experimental data retrieved from single-crystal X-ray diffraction results. Frontier molecular orbitals, such as the HOMO/LUMO energy gap, the molecular electrostatic potential, and Mulliken atomic charges, have been investigated. The HOMO LUMO energy gap of 3.97 eV indicates that the molecule is soft and highly reactive. The Hirshfeld surface analysis and their associated fingerprint plots have been used to quantitatively validate the interactions. Further insilico molecular docking studies have been performed with the molecular target Type-II topoisomerase (PDB ID: 1JIJ) and their results suggest that 4-(tert-butyl)-4-nitro-1,1-biphenyl could be considered an anticancer drug.
A hydroxypropiophenone-based fluorescent probe for the selective determination of Al(III) ions in aqueous ethanol
Authors: Singh Chandni , Singh Divya Pratap , Singh Sunil Kumar , Dwivedi Romi , Singh Ashish Kumar , Singh Vinod Prasad 
Published: March 2023

In this work, we have synthesized a novel dihydrazone-based fluorescent probe N'1,N'2-bis{1-(2-hydroxyphenyl)propylidene}oxalohydrazide (H2hpoh)for Al3+ ions by a simple condensation reaction. The prepared organic probe has been characterized by different physicochemical and spectroscopic techniques. The single-crystal structure of the receptor has also been reported. Crystal data for C20H22N4O4: monoclinic, space group P21/c (no. 14), a = 6.0747(15) Å, b = 11.621(5) Å, c = 13.453(4) Å, β = 94.61(3)°, V = 946.6(5) Å3, Z = 2, T = 293(2) K, μ(MoKα) = 0.096 mm-1, Dcalc = 1.342 g/cm3, 4046 reflections measured (6.076° ≤ 2Θ ≤ 58.05°), 2149 unique (Rint = 0.0876, Rsigma = 0.2223) which were used in all calculations. The final R1 was 0.0972 (I > 2σ(I)) and wR2 was 0.2316 (all data). The ethanolic aqueous solution of the probe shows enhanced fluorescence in the presence of Al3+ ions, whereas no appreciable change in the spectral pattern is observed in the presence of other cations, i.e., Na+, K+, Ca2+, Ba2+, Mn2+, Fe3+, Co2+, Ni2+, Cu2+, Zn2+, Cr3+, Cd2+ and Hg2+. The binding mode of the receptor with Al3+ ions was studied using various spectral titration techniques such as UV-visible, fluorescence, and 1H NMR. The receptor acts as a dibasic hexadentate ligand and interacts with two Al3+ ions with a high binding constant KB = 8.99×1010 1/M. The lowest detection limit for the Al3+ complex of H2hpoh was determined to be 7.8×10−5 M. With the help of DFT calculations, the mechanism of fluorescence enhancement has been explained.
Vehicular ammonia emissions: an underappreciated emission source in densely populated areas
Authors: Wen Yifan , Zhang Shaojun , Wu Ye , Hao Jiming 
Published: March 2023

Abstract. On-road ammonia (NH3) emissions play a significant
role in fine particulate matter (PM2.5) formation in urban areas,
posing severe risks for human health. Limited studies have depicted the
spatial and temporal variations of on-road NH3 emissions, in particular
lacking detailed quantification of their contributions within
densely populated areas. In this study, we established a comprehensive
vehicular NH3 emission model and compiled a gridded on-road NH3
emission inventory with high spatial (3 km × 3 km) and temporal
(monthly) resolution for mainland China. China's annual vehicular NH3
emissions are estimated to increase from 32.8 ± 1.7 to 87.1 ± 37.5 kt during the period of 2000–2019. Vehicular NH3 emissions are
significantly concentrated in densely populated areas, where agricultural
emissions have relatively lower intensity. It is found that vehicular
NH3 emissions could exceed agricultural emissions in the grids
containing 23.0 ± 2.1 % of the Chinese population in 2019
(approximately 326.6 ± 25.4 million people), and this ratio is up to
29.4 ± 3.0 % in winter. For extremely populous megacities such as
Beijing and Shanghai, vehicular NH3 emissions exceed agricultural
emissions, where 69.2 ± 1.2 % and 72.0 ± 1.3 % of the population
resides, respectively. Thus, the significant role of on-road NH3
emissions in populated areas may have been underappreciated. This study gave
a better insight into the absolute value and relative importance of on-road
NH3 emissions for different regions, seasons and population densities in
China; this is important in terms of the implications for air quality.
EURADCLIM: the European climatological high-resolution gauge-adjusted radar precipitation dataset
Authors: Overeem Aart , van den Besselaar Else , van der Schrier Gerard , Meirink Jan Fokke , van der Plas Emiel , Leijnse Hidde 
Published: March 2023

Abstract. The European climatological high-resolution gauge-adjusted radar precipitation dataset, EURADCLIM, addresses the need for an accurate (sub)daily precipitation product covering 78 % of Europe at a high spatial resolution. A climatological dataset of 1 and 24 h precipitation accumulations on a 2 km grid is derived for the period 2013 through 2020. The starting point is the European Meteorological Network (EUMETNET) Operational Program on the Exchange of Weather Radar Information (OPERA) gridded radar dataset of 15 min instantaneous surface rain rates, which is based on data from, on average, 138 ground-based weather radars. First, methods are applied to further remove non-meteorological echoes from these composites by applying two statistical methods and a satellite-based cloud-type mask. Second, the radar composites are merged with the European Climate Assessment &amp; Dataset (ECA&amp;D) with potentially ∼ 7700 rain gauges from National Meteorological and Hydrological Services (NMHSs) in order to substantially improve its quality. Characteristics of the radar, rain gauge and satellite datasets are presented, as well as a detailed account of the applied algorithms. The clutter-removal algorithms are effective while removing few precipitation echoes. The usefulness of EURADCLIM for quantitative precipitation estimation (QPE) is confirmed by comparison against rain gauge accumulations employing scatter density plots, statistical metrics and a spatial verification. These show a strong improvement with respect to the original OPERA product. The potential of EURADCLIM to derive pan-European precipitation climatologies and to evaluate extreme precipitation events is shown. Specific attention is given to the remaining artifacts in and limitations of EURADCLIM. Finally, it is recommended to further improve EURADCLIM by applying algorithms to 3D instead of 2D radar data and by obtaining more rain gauge data for the radar–gauge merging. The EURADCLIM 1 and 24 h precipitation datasets are publicly available at
https://doi.org/10.21944/7ypj-wn68 (Overeem et al., 2022a) and https://doi.org/10.21944/1a54-gg96 (Overeem et al., 2022b).
Feasibility of retrieving Arctic sea ice thickness from the Chinese HY-2B Ku-band radar altimeter
Authors: Dong Zhaoqing , Shi Lijian , Lin Mingsen , Jia Yongjun , Zeng Tao , Wu Suhui 
Published: March 2023

Abstract. With the continuous development of the China ocean dynamic
environment satellite series (Haiyang-2, HY-2), it is urgent to explore the
potential application of HY-2B in Arctic sea ice thickness retrievals. In
this study, we first derive the Arctic radar freeboard and sea ice thickness
during two cycles (from October 2019 to April 2020 and from October 2020 to
April 2021) using the HY-2B radar altimeter and compare the results with the
Alfred Wegener Institute (AWI) CryoSat-2 (CS-2) products. We evaluate our
HY-2B sea ice freeboard and thickness products using Operation IceBridge
(OIB) airborne data and Ice, Cloud, and land Elevation Satellite 2 (ICESat-2) products. Finally, we estimate the uncertainties in the HY-2B sea ice freeboard and sea ice thickness. Here, we
derive the radar freeboard by calculating the difference between the
relative elevation of the floe obtained by subtracting the mean sea surface
(MSS) height and sea surface height anomaly (SSHA) determined by an average
of the 15 lowest points method. The radar freeboard deviation between HY-2B
and CS-2 is within 0.02 m, whereas the sea ice thickness deviation between
HY-2B and CS-2 is within 0.2 m. The HY-2B radar freeboards are generally
thicker than AWI CS-2, except in spring (March and April). A spring segment
likely has more floe points than an early winter segment. We also find that
the deviations in radar freeboard and sea ice thickness between HY-2B and
CS-2 over multiyear
ice (MYI) are larger than those over first-year ice (FYI). The correlation between HY-2B
(CS-2) sea ice freeboard retrievals and OIB values is 0.77 (0.84), with a
root mean square error (RMSE) of 0.13 (0.10) m and a mean absolute error
(MAE) of 0.12 (0.081) m. The correlation between HY-2B (CS-2) sea ice
thickness retrievals and OIB values is 0.65 (0.80), with an RMSE of 1.86
(1.00) m and an MAE of 1.72 (0.75) m. The HY-2B sea ice freeboard
uncertainty values range from 0.021 to 0.027 m, while the uncertainties in
the HY-2B sea ice thickness range from 0.61 to 0.74 m. The future work
will include reprocessing the HY-2B L1 data with a dedicated sea ice
retracker, and using the radar waveforms to directly identify leads to
release products that are more reasonable and suitable for polar sea ice
thickness retrieval.
A Critical Discourse Analysis of Pakistani Edible Oil Companies Advertisements
Authors: Hussain Ijaz , Naqvi Umm-e-Laila , Sohail Sarwat , Nazeer Imran 
Published: March 2023

Media, nowadays, is an essential factor, and it evokes the feelings of the readers and viewers. People nowadays are more concerned about the issues and events happening in the country and worldwide. Media depicts the picture of the entire world to every individual, and it also shapes their ideas. This study aimed to analyze Pakistani edible oil company advertisements from the perspective of Fairclough’s three-dimensional model of Critical Discourse Analysis (CDA). The study ascertained how advertisers convince customers to buy the products using certain linguistic choices in a specific context. In order to achieve this purpose, the researcher selected ads from a Pakistani edible oil company named Kashmir Premium Gold Oil. The theoretical framework opted for this study was Fairclough’s Critical Discourse Analysis (1993). This framework has been used as it shows the connection between social practices and the properties of language. Fairclough’s three-dimensional framework includes three levels of discourse: text, discursive practices, and social practices. The findings show how the ideology of the consumer can be changed by repetition of the advertisement in popular local TV channels and local magazines. The advertisements show an ideal lifestyle and manipulate the customers’ mindset that whatever they have been shown and said through advertisement is true as the advertiser makes them realize that the product was only for their health and better life. Thus, the current study revealed that the language used in the advertisements served as a tool to control the minds of the people.
Táctica en el Tenis Masculino de Alto Nivel - Primera Parte
Authors: Piles Javier , Crespo Miguel 
Published: March 2023

Este artículo expone algunas ideas sobre la táctica en el tenis masculino de alto nivel mediante una combinación de la experiencia de uno de los autores como entrenador de un jugador top 10 y campeón de la Copa Davis, y la aportación teórica del otro autor. Se presentan algunas características fundamentales de la táctica moderna en el alto nivel, se comenta la necesidad de adaptación táctica cuando se cambia de superficie y se enfatiza la importancia del correcto planteamiento de los partidos tanto de forma general como cuando se va a jugar contra alguno de los mejores jugadores del mundo. Finalmente, se proporcionan ejemplos prácticos del trabajo con David Ferrer.
ANALISIS KERAPATAN VEGETASI YANG ADA DI WISATA BUKIT SEJAHTERA, ROMANG LOMPOA KECAMATAN BONTOMARANNU KABUPATEN GOWA
Authors: Rustam Aswar , Hamzah Pratiwi 
Published: March 2023

Hutan merupakan salah satu kekayaan alam yang dapat diperbaharui dan berperan sangat penting dalam menunjang kehidupan dalam hal pertumbuhan ekosistem. Penelitian ini dilakukan untuk mengidentifikasi spesies, sebaran, dominansi, dan keanekaragaman pohon di Kawasan Wisaa Bukit Sejahtera Mawang, Kabupaten Gowa. Ditemukan sebanyak sepuluh spesies pohon menduduki kelima petak contoh yang disebr di dalam kawasan tersebut. Hasil analisis menunjukkan bahwa tidak ada spesies yang mendominasi, namun G. arborea memiliki tingkat kehadiran yang paling tinggi (22 individu). Indeks dominansi (C) menunjukkan nilai pada setiap spesies C < 0,3. Untuk indeks keanekaragaman (H') dan kemerataan (e) juga menunjukkan kategori rendah (H' < 1; e < 0,4). Hal ini berdampak pada analisis pola sebaran (Id) yang juga seragam (Id < 1).