bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Critical Review on the Recycling Strategy of Lithium Iron Phosphate from Electric Vehicles
Authors: Zhang Mingjun , Wang Lifan , Wang Shiqi , Ma Tianyi , Jia Feifei , Zhan Chun 
Published: April 2023

AbstractElectric vehicles (EVs) are one of the most promising decarbonization solutions to develop a carbon‐negative economy. The increasing global storage of EVs brings out a large number of power batteries requiring recycling. Lithium iron phosphate (LFP) is one of the first commercialized cathodes used in early EVs, and now gravimetric energy density improvement makes LFP with low cost and robustness popular again in the market. Developments in LFP recycling techniques are in demand to manage a large portion of the EV batteries retired both today and around ten years later. In this review, first the operation and degradation mechanisms of LFP are revisited aiming to identify entry points for LFP recycling. Then, the current LFP recycling methods, from the pretreatment of the retired batteries to the regeneration and recovery of the LFP cathode are summarized. The emerging direct recovery technology is highlighted, through which both raw material and the production cost of LFP can be recovered. In addition, the current issues limiting the development of the LIBs recycling industry are presented and some ideas for future research are proposed. This review provides the theoretical basis and insightful perspectives on developing new recycling strategies by outlining the whole‐life process of LFP.
Integrated Surface Modulation of Ultrahigh Ni Cathode Materials for Improved Battery Performance
Authors: Qi Mu‐Yao , Zhang Si‐Dong , Guo Sijie , Ji Peng‐Xiang , Mao Jian‐Jun , Wu Ting‐Ting , Lu Si‐Qi , Zhang Xing , Chen Shu‐Guang , Su Dong , Chen Guan‐Hua , Cao An‐Min 
Published: April 2023

AbstractNi‐rich layered cathodes with ultrahigh nickel content (≥90%), for example LiNi0.9Co0.1O2 (NC0.9), are promising for next‐generation high‐energy Li‐ion batteries (LIBs), but face stability issues related to structural degradation and side reactions during the electrochemical process. Here, surface modulation is demonstrated by integrating a Li+‐conductive nanocoating and gradient lattice doping to stabilize the active cathode efficiently for extended cycles. Briefly, a wet‐chemistry process is developed to deposit uniform ZrO(OH)2 nanoshells around Ni0.905Co0.095(OH)2(NC0.9‐OH) hydroxide precursors, followed by high temperature lithiation to create reinforced products featuring Zr doping in the crust lattice decorated with Li2ZrO3 nanoparticles on the surface. It is identified that the Zr4+ infiltration reconstructed the surface lattice into favorable characters such as Li+ deficiency and Ni3+ reduction, which are effective to combat side reactions and suppress phase degradation and crack formation. This surface control is able to achieve an optimized balance between surface stabilization and charge transfer, resulting in an extraordinary capacity retention of 96.6% after 100 cycles at 1 C and an excellent rate capability of 148.8 mA h g−1 at 10 C. This study highlights the critical importance of integrated surface modulation for high stability of cathode materials in next‐generation LIBs.
Design method for bridge deck link slabs prepared using BFRP bar‐reinforced ecological high‐ductility cementitious composites by theoretical calculation and numerical simulation
Authors: Chai Li‐Juan , Chen Bo , Guo Li‐Ping , Li Kai 
Published: April 2023

AbstractBridge deck link slabs prepared using Basalt Fiber Reinforced Polymer (BFRP) bar‐reinforced ecological high‐ductility cementitious composites (Eco‐HDCC) were applied as substitutes for steel expansion joints in Malin Bridge. Theoretical calculations and numerical simulations were combined to develop a design method. The total length and debond length of the link slabs were assumed based on the bridge information, and the reinforcement ratio of the BFRP bar was calculated using the maximum crack width limit. Then, the flexural capacity of the link slabs was evaluated. A preliminary reinforcement program using eight reinforcement ratios and different bar diameters was developed. In addition, the maximum stresses, strains, and deflections of the link slabs were validated through Abaqus finite element analysis. The simulation results of the reinforcement programs with minor reinforcement ratios are similar. The maximum stresses, strains, and deflections of the link slab materials are significantly lower than the design ultimate capacities of the materials, implying that the eight reinforcement programs are feasible. Because the thickness of the link slabs is within the range of 80–120 mm, a small‐diameter bar is preferable. Furthermore, BFRP bars with diameters of 10–14 mm are suitable along the driving direction, whereas BFRP bars with diameters of 10 mm are recommended along the direction perpendicular to the driving direction. A detailed design method flowchart for bridge deck link slabs was constructed to serve as a guideline for engineers.
Effect of ground granulated blast furnace slag on the properties of hybrid‐fiber‐reinforced high‐strength concrete under normal and high temperatures
Authors: Rezvaniyanzadeh Alireza , Fadaee Mohammad Javad 
Published: April 2023

AbstractIn this paper, the residual mechanical properties, mass loss, and cracking behavior of hybrid‐fiber‐reinforced high‐strength concrete (HFRHSC) containing 0%, 30%, and 60% ground granulated blast furnace slag (GGBFS) in normal and high temperatures have been investigated. Chopped aramid and steel fibers at 0%, 0.5%, and 1% by volume, either individually or in different combinations, were used to reinforce the HSC. In total, 24 different mix proportions were designed. The experimental results showed that the residual compressive strength of the majority of specimens increased at 400°C while this property of all of them decreased at 800°C. Also, the test indicated that the use of GGBFS did not reduce flexural and compressive strength of HSC significantly, and in some mixed designs, the presence of GGBFS slightly increases the strength. Moreover, another result that can be inferred is that although the utilization of hybrid fibers in concrete increases flexural strength, it may decrease its compressive strength. In addition, the residual flexural strength of most specimens was reduced at 400°C, but this property of all samples decreased at 800°C. The results showed that the simultaneous presence of GGBFS and hybrid fibers can improve the flexural strength of most specimens at different temperatures.
Experimental investigation of a precast segmental Twin‐Deck box girder bridge simultaneously erected with double bridge erection gantries
Authors: Su Xiaolong , Zhou Man , Zhong Jitao 
Published: April 2023

AbstractPrecast segmental construction can shorten the construction time of the bridge and reduce the impacts on traffic and environment. Thus, this approach has been widely used in many countries. The relevant literature suggests that in the existing segmental precast bridges, nearly all of the centerlines of the girders are aligned with the centerline of the bridge piers. This paper introduces a wide urban viaduct comprising twin separate box girder cells using segmental prefabrication. To save space under the bridge, the bridge has only one row of piers and long cantilever crossbeams are set at the top of each pier. Additionally, the centerline of the girder and the centerline of the pier do not overlap. To prevent eccentric loading and improve the construction speed, two bridge erection gantries are used for synchronous construction. This study is a pioneering attempt at bridge construction with a precast segmental twin‐deck box girder bridge simultaneously erected with double gantries. To investigate the stress state of the whole system (crossbeam, gantries, and box girder segments) during construction and demonstrate the feasibility of the construction method, a real bridge was used. The test results provide a reference for the design and construction of similar projects.
Oxygen transfer comparison of jets and coarse bubble aeration in concentrated sludge
Authors: Steele Paul , Warner Rick , Rosso Diego 
Published: April 2023

AbstractThe South Truckee Meadows Water Reclamation Facility (STMWRF) in Washoe County, Nevada, commissioned a biosolids facility with jet aerated aerobic digestion. The jet aerators were not performing as designed, so they were tested on‐site in the new tanks in both clean and process water according to ASCE standards. The aerators failed by substantial margins. To make up for the aeration shortfall, Washoe County elected to replace the jet aerators with coarse bubble aerators and to add the additional blower capacity necessary to meet the oxygen requirements in this configuration. After partial replacement, with one basin containing coarse bubble diffusers and the other still containing jets, the efficiency of both systems was tested in process water. The jets and coarse bubble diffusers had similar results for OTE and αSOTE, whereas the coarse bubble diffusers had substantially higher aeration efficiency after accounting for the jet pump power draw. Overall, the project demonstrated the deleterious effects of highly concentrated non‐Newtonian sludge on the coalescence of fine bubbles and ultimately jet aeration efficiency, confirming the incompatibility of fine bubbles and thick sludge. Our results can be extended to other bioreactors operating at MLSS concentration above 1%.Practitioner PointsFine bubble systems perform worse than coarse bubbles in thick sludge due to bubble coalescence.The alpha factor is a function of sludge thickness; hence, claims of constant alpha are unrealistic.Polymers and additives for sludge thickening should be carefully evaluated because they can affect adversely oxygen transfer.Independent verification of aeration system manufacturer claims prevents design issues and subsequent disputes.
On the existence of m-norms in vector spaces over valued fields
Authors: Schwaiger Jens 
Published: April 2023

AbstractGähler (Untersuchungen über verallgemeinerte m-metrische Räume. I”. German. Math Nachr 40, 165–189, 1969) investigated m-metric spaces and in particular m-normed spaces over the field of reals. Here the existence of m-norms will be investigated and this in the more general setting of vector spaces over arbitrary non-trivial valued fields.
Beyond the hype: ‘acceptable futures’ for AI and robotic technologies in healthcare
Authors: De Togni Giulia , Erikainen S. , Chan S. , Cunningham-Burley S. 
Published: April 2023

AbstractAI and robotic technologies attract much hype, including utopian and dystopian future visions of technologically driven provision in the health and care sectors. Based on 30 interviews with scientists, clinicians and other stakeholders in the UK, Europe, USA, Australia, and New Zealand, this paper interrogates how those engaged in developing and using AI and robotic applications in health and care characterize their future promise, potential and challenges. We explore the ways in which these professionals articulate and navigate a range of high and low expectations, and promissory and cautionary future visions, around AI and robotic technologies. We argue that, through these articulations and navigations, they construct their own perceptions of socially and ethically ‘acceptable futures’ framed by an ‘ethics of expectations.’ This imbues the envisioned futures with a normative character, articulated in relation to the present context. We build on existing work in the sociology of expectations, aiming to contribute towards better understanding of how technoscientific expectations are navigated and managed by professionals. This is particularly timely since the COVID-19 pandemic gave further momentum to these technologies.
Analytical investigation of the finite viscoelastic model proposed by Simo: critical review and a suggested modification
Authors: Yagimli Bülent , Lion Alexander , Abdelmoniem Mohamed A. 
Published: April 2023

AbstractRubber components such as engine or suspension bearings are loaded during operation with large deformations and high-frequency loads. In industrial applications, finite element analysis software is therefore needed to simulate and predict the behaviour of these components under different scenarios of loading conditions. The usage of such software requires the user to be aware of certain limitations and shortcomings in the implemented material models. In this paper, the stresses as well as the storage and loss modulus are calculated analytically for an example of cyclic simple shear deformations. The analysed material model was firstly proposed by Simo and is available in Abaqus version 2018 for viscoelastic materials under finite strains. The analytical solution is used to highlight the non-physical response of the model under certain loading conditions. A modification of the modelling approach is then proposed to avoid such limitations. The modified model is implemented in the Abaqus software using a user material subroutine (UMAT). The behaviour of the modified model and the original Abaqus model are compared using an example of tie rod under different loading conditions. It is shown that with the suggested modification, reasonable results are obtained and the non-physical responses are eliminated.
Peptide extract from spent yeast improves resistance of Saccharomyces cerevisiae to oxidative stress
Authors: Lopes Ana , Azevedo-Silva João , Carsanba Erdem , Pintado Manuela , Oliveira Ana Sofia , Ferreira Carlos , Pereira Joana Odila , Carvalho Ana P. , Oliveira Carla 
Published: April 2023

Abstract
Yeast cells face various stress factors during industrial fermentations, since they are exposed to harsh environmental conditions, which may impair biomolecules productivity and yield. In this work, the use of an antioxidant peptide extract obtained from industrial spent yeast was explored as supplement for Saccharomyces cerevisiae fermentation to prevent a common bottleneck: oxidative stress. For that, a recombinant yeast strain, producer of β-farnesene, was firstly incubated with 0.5 and 0.7 g/L peptide extract, in the presence and absence of hydrogen peroxide (an oxidative stress inducer), for 1–5 h, and then assayed for intracellular reactive oxygen species, and growth ability in agar spot assays. Results showed that under 2 mM H2O2, the peptide extract could improve cells growth and reduce reactive oxygen species production. Therefore, this antioxidant effect was further evaluated in shake-flasks and 2-L bioreactor batch fermentations. Peptide extract (0.7 g/L) was able to increase yeast resistance to the oxidative stress promoted by 2 mM H2O2, by reducing reactive oxygen species levels between 1.2- and 1.7-fold in bioreactor and between 1.2- and 3-fold in shake-flask fermentations. Moreover, improvements on yeast cell density of up to 1.5-fold and 2-fold, and on biomolecule concentration of up to 1.6-fold and 2.8-fold, in bioreactor and shake-flasks, respectively, were obtained. Thus, culture medium supplementation with antioxidant peptide extracted from industrial spent yeast is a promising strategy to improve fermentation performance while valuing biomass waste. This valorization can promote a sustainable and eco-friendly solution for the biotechnology industry by the implementation of a circular economy model.

Key points
• Peptide extract from spent yeast applied for the first time on yeast fermentation.
• Antioxidant peptide extract enhanced S. cerevisiae oxidative stress resistance.
• Fermentation performance under stress improved by peptide extract supplementation.
Fibroblast activation protein targeted radiotherapy induces an immunogenic tumor microenvironment and enhances the efficacy of PD-1 immune checkpoint inhibition
Authors: Zboralski Dirk , Osterkamp Frank , Christensen Esben , Bredenbeck Anne , Schumann Anne , Hoehne Aileen , Schneider Eberhard , Paschke Matthias , Ungewiss Jan , Haase Christian , Robillard Liliane , Simmons Andrew D. , Harding Thomas C. , Nguyen Minh 
Published: April 2023

Abstract
Purpose
FAP is a membrane-bound protease under investigation as a pan-cancer target, given its high levels in tumors but limited expression in normal tissues. FAP-2286 is a radiopharmaceutical in clinical development for solid tumors that consists of two functional elements: a FAP-targeting peptide and a chelator used to attach radioisotopes. Preclinically, we evaluated the immune modulation and anti-tumor efficacy of FAP-2287, a murine surrogate for FAP-2286, conjugated to the radionuclide lutetium-177 (177Lu) as a monotherapy and in combination with a PD-1 targeting antibody.

Methods
C57BL/6 mice bearing MCA205 mouse FAP-expressing tumors (MCA205-mFAP) were treated with 177Lu-FAP-2287, anti-PD-1, or both. Tumor uptake of 177Lu- FAP-2287 was assessed by SPECT/CT scanning, while therapeutic efficacy was measured by tumor volume and survival. Immune profiling of tumor infiltrates was evaluated through flow cytometry, RNA expression, and immunohistochemistry analyses.

Results
177Lu-FAP-2287 rapidly accumulated in MCA205-mFAP tumors leading to significant tumor growth inhibition (TGI) and longer survival time. Significant TGI was also observed from anti-PD-1 and the combination. In flow cytometry analysis of tumors, 177Lu-FAP-2287 increased CD8+ T cell infiltration which was maintained in the combination with anti-PD-1. The increase in CD8+ T cells was accompanied by an induction of STING-mediated type I interferon response and higher levels of co-stimulatory molecules such as CD86.

Conclusion
In a preclinical model, FAP-targeted radiotherapy enhanced anti-PD-1-mediated TGI by modulating the TME and increasing the recruitment of tumor-infiltrating CD8+ T cells. These findings provide a rationale for clinical studies of combined 177Lu-FAP-2286 radiotherapy and immune checkpoint inhibition in FAP-positive tumors.
Ground kinematically aligned total knee arthroplasty: new personalized technique which enables a stable knee with deep flexion
Authors: Matsumoto Tomoyuki , Nakano Naoki , Ishida Kazunari , Kuroda Yuichi , Hayashi Shinya , Muratsu Hirotsugu , Kuroda Ryosuke 
Published: April 2023

Abstract
Purpose
This study aimed to evaluate kinematically aligned total knee arthroplasty (KA-TKA) targeting the neutral ground mechanical axis (MA) (hip-to-calcaneus axis), the line from the hip centre to the bottom of the calcaneus, (ground KA-TKA) in terms of its comparison with tibia-restricted modified KA-TKA (modified KA-TKA).

Methods
This retrospective cohort study included 106 consecutive patients who underwent unilateral KA-TKA for varus osteoarthritis (OA) (60 modified KA-TKAs and 46 ground KA-TKAs). After 1:1 propensity score matching, 60 patients (30 pairs) were matched between the groups with comparable demographic data. The hip-knee-ankle (HKA) angle, coronal femoral component alignment (FCA), and coronal tibial component alignment (TCA) were compared between groups. Intraoperative soft tissue balance, including the joint component gap and varus/valgus balance, was also compared between the groups. One year postoperatively, the clinical outcomes, including the range of motion and 2011 Knee Society Score, were compared between groups.

Results
The HKA angle and FCA/TCA were not significantly different between groups. Whereas the varus/valgus balance showed no significant differences between groups, smaller joint component gaps were found throughout the range of motion in the ground KA-TKA group than in the modified KA-TKA group. Despite no difference in clinical scores between groups, a significantly deeper postoperative flexion angle was achieved in the ground KA-TKA group than in the modified KA-TKA group (p < 0.05).

Conclusion
Targeting neutral ground MA in KA-TKA for patients with varus OA has the potential to provide a better flexion angle with stable intraoperative soft tissue balance.
Simple and safe digitoxin dosing in heart failure based on data from the DIGIT-HF trial
Authors: Bavendiek Udo , Großhennig Anika , Schwab Johannes , Berliner Dominik , Liu Xiaofei , Maier Lars , Gaspar Thomas , Rieth Andreas , Philipp Sebastian , Hambrecht Rainer , Westenfeld Ralf , Münzel Thomas , Winkler Sebastian , Hülsmann Martin , Westermann Dirk , Zdravkovic Marja , Lichtinghagen Ralf , von der Leyen Heiko , Zimmermann Silke , Veltmann Christian , Böhm Michael , Störk Stefan , Koch Armin , Bauersachs Johann 
Published: April 2023

Abstract
Background
The present study aimed to develop a simple dosing score when starting the cardiac glycoside digitoxin in heart failure with reduced ejection fraction (HFrEF) employing first data from the randomized, double-blinded DIGIT-HF trial.

Methods and results
In DIGIT-HF, digitoxin was started with a dose of 0.07 mg once daily (o.d.) in all patients. For score derivation, 317 patients were analyzed who had been randomized to digitoxin. In these patients, after scheduled determination of serum levels at study week 6, the digitoxin dose had remained unchanged or had been reduced to 0.05 mg o.d. (97% of patients) to achieve serum concentrations within a predefined range (10.5–23.6 nmol/l). In logistic regression analyses, sex, age, body mass index (BMI), and estimated glomerular filtration rate (eGFR) were associated with need for dose reduction and, therefore, selected for further developing the dosing score. Optimal cut-points were derived from ROC curve analyses. Finally, female sex, age ≥ 75 years, eGFR < 50 ml/min/1.73 m2, and BMI < 27 kg/m2 each were assigned one point for the digitoxin dosing score. A score of ≥ 1 indicated the need for dose reduction with sensitivity/specificity of 81.6%/49.7%, respectively. Accuracy was confirmed in a validation data set including 64 patients randomized to digitoxin yielding sensitivity/specificity of 87.5%/37.5%, respectively.

Conclusion
In patients with HFrEF, treatment with digitoxin should be started at 0.05 mg o.d. in subjects with either female sex, eGFR < 50 ml/min/1.73m2, BMI < 27 kg/m2, or age ≥ 75 years. In any other patient, digitoxin may be safely started at 0.07 mg o.d.

Graphical Abstract