bluuebunny/crossref_metadata_2025_split huggingface dataset:
Volcano‐Magnetic Signal Reveals Rapid Evolution of the Inner Structure of Piton de la Fournaise
Authors: Gailler Lydie , Labazuy Philippe , Dumont Quentin , Froger Jean‐Luc , Peltier Aline , Finizola Anthony , Cayol Valérie , Chaput Marie , Régis Edouard ,   The SlideVolc ERT Team
Published: January 2023

AbstractNear‐real time analysis of magnetization can provide important information for the imaging of volcano systems and their spatiotemporal evolution. This study focuses on the contribution of volcano‐magnetic signals from reiterations of ground magnetic measurements to investigate the evolution of active structures at the Piton de la Fournaise volcano from 2017 to 2020. Changes are demonstrated by magnetic anomalies along a reference profile by means of the reiteration periods. These variations are first modeled qualitatively in 2D using electrical resistivity constraints in order to investigate the evolution of magnetization at depth through time, and the model is subsequently compared with the 3D intrusive activity from depth up to the surface from Interferometric Synthetic Aperture Radar (InSAR) inverse modeling. The shallow areas of demagnetization modeled from one reiteration to another are consistent with the geometry and location of the underlying intrusions revealed by the 3D InSAR models, suggesting strong thermal, stress, and electrokinetic effects due to magmatic activity not only at the surface but also at depth, along the main magmatic paths. It also raises a question as to the extent of the associated thermal diffusion processes at the scale of individual magma injections. This study confirms that detecting resistivity and magnetization anomalies, and quantifying their spatiotemporal evolution, can provide powerful tools for imaging volcanic systems at various scales and for providing warning of associated hazards. It also highlights the necessity for 4D monitoring of volcanic edifices using this method to provide greater precision, an important issue that is now made possible by the use of Unmanned Aerial Vehicle measurements.
Investigation of the Geomagnetically Induced Current Index Levels in the Mediterranean Region During the Strongest Magnetic Storms of Solar Cycle 24
Authors: Boutsi A. Z. , Balasis G. , Dimitrakoudis S. , Daglis I. A. , Tsinganos K. , Papadimitriou C. , Giannakis O. 
Published: January 2023

AbstractGeomagnetically induced currents (GICs) constitute an integral part of space weather research and are a subject of ever‐growing attention for countries located in the low and middle latitudes. A series of recent studies highlights the importance of considering GIC risks for the Mediterranean region. Here, we exploit data from the HellENIc GeoMagnetic Array, which is deployed in Greece, complemented by magnetic observatories in the Mediterranean region (Italy, France, Spain, Algeria, and Turkey), to calculate values of the GIC index, that is, a proxy of the geoelectric field calculated entirely from geomagnetic field variations. We perform our analysis for the most intense magnetic storms (Dst < −150 nT) of solar cycle 24. Our results show that GIC index increases are well correlated with storm sudden commencements. However, the GIC indices do not exceed “low” activity levels despite the increases in their values, at all magnetic stations/observatories under study during the selected storm events.
Distinct and shared patterns of brain plasticity during electroconvulsive therapy and treatment as usual in depression: an observational multimodal MRI-study
Authors: Bracht Tobias , Walther Sebastian , Breit Sigrid , Mertse Nicolas , Federspiel Andrea , Meyer Agnes , Soravia Leila M. , Wiest Roland , Denier Niklaus 
Published: January 2023

AbstractElectroconvulsive therapy (ECT) is a highly effective treatment for depression. Previous studies point to ECT-induced volume increase in the hippocampi and amygdalae, and to increase in cortical thickness. However, it is unclear if these neuroplastic changes are associated with treatment response. This observational study aimed to address this research question by comparing neuroplasticity between patients with depression receiving ECT and patients with depression that respond to treatment as usual (TAU-responders). Twenty ECT-patients (16 major depressive disorder (MDD), 4 depressed bipolar disorder), 20 TAU-responders (20 MDD) and 20 healthy controls (HC) were scanned twice with multimodal magnetic resonance imaging (structure: MP2RAGE; perfusion: arterial spin labeling). ECT-patients were scanned before and after an ECT-index series (ECT-group). TAU-responders were scanned during a depressive episode and following remission or treatment response. Volumes and cerebral blood flow (CBF) of the hippocampi and amygdalae, and global mean cortical thickness were compared between groups. There was a significant group × time interaction for hippocampal and amygdalar volumes, CBF in the hippocampi and global mean cortical thickness. Hippocampal and amygdalar enlargements and CBF increase in the hippocampi were observed in the ECT-group but neither in TAU-responders nor in HC. Increase in global mean cortical thickness was observed in the ECT-group and in TAU-responders but not in HC. The co-occurrence of increase in global mean cortical thickness in both TAU-responders and in ECT-patients may point to a shared mechanism of antidepressant response. This was not the case for subcortical volume and CBF increase.
The macroevolutionary impact of recent and imminent mammal extinctions on Madagascar
Authors: Michielsen Nathan M. , Goodman Steven M. , Soarimalala Voahangy , van der Geer Alexandra A. E. , Dávalos Liliana M. , Saville Grace I. , Upham Nathan , Valente Luis 
Published: January 2023

AbstractMany of Madagascar’s unique species are threatened with extinction. However, the severity of recent and potential extinctions in a global evolutionary context is unquantified. Here, we compile a phylogenetic dataset for the complete non-marine mammalian biota of Madagascar and estimate natural rates of extinction, colonization, and speciation. We measure how long it would take to restore Madagascar’s mammalian biodiversity under these rates, the “evolutionary return time” (ERT). At the time of human arrival there were approximately 250 species of mammals on Madagascar, resulting from 33 colonisation events (28 by bats), but at least 30 of these species have gone extinct since then. We show that the loss of currently threatened species would have a much deeper long-term impact than all the extinctions since human arrival. A return from current to pre-human diversity would take 1.6 million years (Myr) for bats, and 2.9 Myr for non-volant mammals. However, if species currently classified as threatened go extinct, the ERT rises to 2.9 Myr for bats and 23 Myr for non-volant mammals. Our results suggest that an extinction wave with deep evolutionary impact is imminent on Madagascar unless immediate conservation actions are taken.
Age-related matrix stiffening epigenetically regulates α-Klotho expression and compromises chondrocyte integrity
Authors: Iijima Hirotaka , Gilmer Gabrielle , Wang Kai , Bean Allison C. , He Yuchen , Lin Hang , Tang Wan-Yee , Lamont Daniel , Tai Chia , Ito Akira , Jones Jeffrey J. , Evans Christopher , Ambrosio Fabrisia 
Published: January 2023

AbstractExtracellular matrix stiffening is a quintessential feature of cartilage aging, a leading cause of knee osteoarthritis. Yet, the downstream molecular and cellular consequences of age-related biophysical alterations are poorly understood. Here, we show that epigenetic regulation of α-Klotho represents a novel mechanosensitive mechanism by which the aged extracellular matrix influences chondrocyte physiology. Using mass spectrometry proteomics followed by a series of genetic and pharmacological manipulations, we discovered that increased matrix stiffness drove Klotho promoter methylation, downregulated Klotho gene expression, and accelerated chondrocyte senescence in vitro. In contrast, exposing aged chondrocytes to a soft matrix restored a more youthful phenotype in vitro and enhanced cartilage integrity in vivo. Our findings demonstrate that age-related alterations in extracellular matrix biophysical properties initiate pathogenic mechanotransductive signaling that promotes Klotho promoter methylation and compromises cellular health. These findings are likely to have broad implications even beyond cartilage for the field of aging research.
Decreased but diverse activity of cortical and thalamic neurons in consciousness-impairing rodent absence seizures
Authors: McCafferty Cian , Gruenbaum Benjamin F. , Tung Renee , Li Jing-Jing , Zheng Xinyuan , Salvino Peter , Vincent Peter , Kratochvil Zachary , Ryu Jun Hwan , Khalaf Aya , Swift Kohl , Akbari Rashid , Islam Wasif , Antwi Prince , Johnson Emily A. , Vitkovskiy Petr , Sampognaro James , Freedman Isaac G. , Kundishora Adam , Depaulis Antoine , David François , Crunelli Vincenzo , Sanganahalli Basavaraju G. , Herman Peter , Hyder Fahmeed , Blumenfeld Hal 
Published: January 2023

AbstractAbsence seizures are brief episodes of impaired consciousness, behavioral arrest, and unresponsiveness, with yet-unknown neuronal mechanisms. Here we report that an awake female rat model recapitulates the behavioral, electroencephalographic, and cortical functional magnetic resonance imaging characteristics of human absence seizures. Neuronally, seizures feature overall decreased but rhythmic firing of neurons in cortex and thalamus. Individual cortical and thalamic neurons express one of four distinct patterns of seizure-associated activity, one of which causes a transient initial peak in overall firing at seizure onset, and another which drives sustained decreases in overall firing. 40–60 s before seizure onset there begins a decline in low frequency electroencephalographic activity, neuronal firing, and behavior, but an increase in higher frequency electroencephalography and rhythmicity of neuronal firing. Our findings demonstrate that prolonged brain state changes precede consciousness-impairing seizures, and that during seizures distinct functional groups of cortical and thalamic neurons produce an overall transient firing increase followed by a sustained firing decrease, and increased rhythmicity.
Introducing the Dendrify framework for incorporating dendrites to spiking neural networks
Authors: Pagkalos Michalis , Chavlis Spyridon , Poirazi Panayiota 
Published: January 2023

AbstractComputational modeling has been indispensable for understanding how subcellular neuronal features influence circuit processing. However, the role of dendritic computations in network-level operations remains largely unexplored. This is partly because existing tools do not allow the development of realistic and efficient network models that account for dendrites. Current spiking neural networks, although efficient, are usually quite simplistic, overlooking essential dendritic properties. Conversely, circuit models with morphologically detailed neuron models are computationally costly, thus impractical for large-network simulations. To bridge the gap between these two extremes and facilitate the adoption of dendritic features in spiking neural networks, we introduce Dendrify, an open-source Python package based on Brian 2. Dendrify, through simple commands, automatically generates reduced compartmental neuron models with simplified yet biologically relevant dendritic and synaptic integrative properties. Such models strike a good balance between flexibility, performance, and biological accuracy, allowing us to explore dendritic contributions to network-level functions while paving the way for developing more powerful neuromorphic systems.
Field-induced Lifshitz transition in the magnetic Weyl semimetal candidate PrAlSi
Authors: Wu Lei , Chi Shengwei , Zuo Huakun , Xu Gang , Zhao Lingxiao , Luo Yongkang , Zhu Zengwei 
Published: January 2023

AbstractLifshitz transition (LT) refers to an abrupt change in the electronic structure and Fermi surface and is associated to a variety of emergent quantum phenomena. Amongst the LTs observed in known materials, the field-induced LT has been rare and its origin remains elusive. To understand the origin of field-induced LT, it is important to extend the material basis beyond the usual setting of heavy fermion metals. Here, we report on a field-induced LT in PrAlSi, a magnetic Weyl semimetal candidate with localized 4felectrons, through a study of magnetotransport up to 55 T. The quantum oscillation analysis reveals that across a threshold fieldB* ≈ 14.5 T the oscillation frequency (F1 = 43 T) is replaced by two new frequencies (F2 = 62 T andF3 = 103 T). Strikingly, the LT occurs well below the quantum limit, with obvious temperature-dependent oscillation frequency and field-dependent cyclotron mass. Our work not only enriches the rare examples of field-induced LTs but also paves the way for further investigation of the interplay among topology, magnetism, and electronic correlation.
Laboratory diagnosed microbial infection in English UK Biobank participants in comparison to the general population
Authors: Hilton Bridget , Wilson Daniel J. , O’Connell Anne-Marie , Ironmonger Dean , Rudkin Justine K. , Allen Naomi , Oliver Isabel , Wyllie David H. 
Published: January 2023

AbstractUnderstanding the genetic and environmental risk factors for serious bacterial infections in ageing populations remains incomplete. Utilising the UK Biobank (UKB), a prospective cohort study of 500,000 adults aged 40–69 years at recruitment (2006–2010), can help address this. Partial implementation of such a system helped groups around the world make rapid progress understanding risk factors for SARS-CoV-2 infection and COVID-19, with insights appearing as early as May 2020. In principle, such approaches could also to be used for bacterial isolations. Here we report feasibility testing of linking an England-wide dataset of microbial reporting to UKB participants, to enable characterisation of microbial infections within the UKB Cohort. These records pertain mainly to bacterial isolations; SARS-CoV-2 isolations were not included. Microbiological infections occurring in patients in England, as recorded in the Public Health England second generation surveillance system (SGSS), were linked to UKB participants using pseudonymised identifiers. By January 2015, ascertainment of laboratory reports from UKB participants by SGSS was estimated at 98%. 4.5% of English UKB participants had a positive microbiological isolate in 2015. Half of UKB isolates came from 12 laboratories, and 70% from 21 laboratories. Incidence rate ratios for microbial isolation, which is indicative of serious infection, from the UKB cohort relative to the comparably aged general population ranged from 0.6 to 1, compatible with the previously described healthy participant bias in UKB. Data on microbial isolations can be linked to UKB participants from January 2015 onwards. This linked data would offer new opportunities for research into the role of bacterial agents on health and disease in middle to-old age.
Mental health of UK firefighters
Authors: Wolffe Taylor A. M. , Robinson Andrew , Clinton Anna , Turrell Louis , Stec Anna A. 
Published: January 2023

AbstractExposure to trauma, high-stress situations, and disrupted sleep are well known risk factors affecting firefighters’ mental health. Little is known about the association between firefighters’ exposure to fire contaminants and mental health disorders. The UK Firefighter Contamination Survey assessed firefighters’ health and capacity for occupational exposure to contaminants. Participants were invited to anonymously complete its 64 questions online. Logistic regression analyses assessed the associations between self-reported mental health disorders and proxies of contaminant exposure. Results found that firefighters who notice soot in their nose/throat for more than a day after attending fires (Odds Ratio (OR) = 1.8, 1.4–2.4), and those who remain in their personal protective equipment (PPE) for over 4 h after fires (OR = 1.9, 1.2–3.1), were nearly twice as likely to report mental health disorders. Significantly increased odds ratios for all three outcomes of interest (anxiety, depression and/or any mental health disorders) were also found among firefighters who take PPE home to clean. Sleeping problems were reported by 61% of firefighters. These firefighters were 4.2 times more likely to report any mental health disorder (OR = 4.2, 3.7–4.9), 2.9 times more likely to report anxiety (OR = 2.9, 2.4–3.5) and 2.3 times more likely to report depression (OR = 2.3, 1.9–2.8) when compared to firefighters who did not report sleep issues. Effective decontamination measures within UK Fire and Rescue Services, together with firefighters’ wellness, may play a crucial role in protecting firefighters’ mental health.
Culture and awareness of occupational health risks amongst UK firefighters
Authors: Wolffe Taylor A. M. , Turrell Louis , Robinson Andrew , Dickens Kathryn , Clinton Anna , Maritan-Thomson Daniella , Stec Anna A. 
Published: January 2023

AbstractFirefighters are exposed to toxic chemicals not only from the fire incidents they attend, but also from their contaminated station and/or personal protective equipment (PPE). Little is currently known about firefighters’ awareness, attitudes, and behaviours towards contaminants which was assessed in the UK firefighter contamination survey. Results revealed that lack of training on fire effluents and their health outcomes are strongly associated with increased fire smoke/contaminant exposure. Notably, untrained firefighters were at least twice as likely to: never clean personal protective equipment (PPE) (Crude Odds Ratio, OR 2.0, 1.5–2.7), infrequently send their PPE for professional cleaning (OR 2.0, 1.6–2.4), remain in the workwear (t-shirt etc.) worn while attending a fire incident (OR up to 3.6, 2.3–5.6), and indicate that cleaning at fire stations is not taken seriously (OR 2.4, 2.2–2.6). Firefighters personally viewing contamination as a “badge of honour” (BoH) were at least twice as likely to: remain in contaminated PPE after fire incidents (OR 2.3, 1.4–3.9), eat with sooty hands (OR 2.2, 1.9–2.5), notice soot in the nose/throat (OR 3.7, 2.7–5.2), and smell fire smoke on the body for more than a day after incidents (OR 2.0, 1.6–2.4). They were also more likely to indicate that cleaning at fire stations is not taken seriously (OR 2.5, 2.2–2.9) and that fire stations smell of smoke always/most of the time (OR 2.3, 2.0–2.6). Strong links were also found between belief in the BoH and never cleaning PPE (OR 1.9, 1.4–2.7), and eating while wearing contaminated PPE (OR 1.8, 1.5–2.2).
Learning the dynamics of realistic models of C. elegans nervous system with recurrent neural networks
Authors: Barbulescu Ruxandra , Mestre Gonçalo , Oliveira Arlindo L. , Silveira Luís Miguel 
Published: January 2023

AbstractGiven the inherent complexity of the human nervous system, insight into the dynamics of brain activity can be gained from studying smaller and simpler organisms. While some of the potential target organisms are simple enough that their behavioural and structural biology might be well-known and understood, others might still lead to computationally intractable models that require extensive resources to simulate. Since such organisms are frequently only acting as proxies to further our understanding of underlying phenomena or functionality, often one is not interested in the detailed evolution of every single neuron in the system. Instead, it is sufficient to observe the subset of neurons that capture the effect that the profound nonlinearities of the neuronal system have in response to different stimuli. In this paper, we consider the well-known nematodeCaenorhabditis elegansand seek to investigate the possibility of generating lower complexity models that capture the system’s dynamics with low error using only measured or simulated input-output information. Such models are often termed black-box models. We show how the nervous system ofC. eleganscan be modelled and simulated with data-driven models using different neural network architectures. Specifically, we target the use of state-of-the-art recurrent neural network architectures such as Long Short-Term Memory and Gated Recurrent Units and compare these architectures in terms of their properties and their accuracy (Root Mean Square Error), as well as the complexity of the resulting models. We show that Gated Recurrent Unit models with a hidden layer size of 4 are able to accurately reproduce the system response to very different stimuli. We furthermore explore the relative importance of their inputs as well as scalability to more scenarios.
Contamination of UK firefighters personal protective equipment and workplaces
Authors: Wolffe Taylor A. M. , Clinton Anna , Robinson Andrew , Turrell Louis , Stec Anna A. 
Published: January 2023

AbstractFirefighters’ personal protective equipment (PPE) is a potential source of chronic exposure to toxic contaminants commonly released from fires. These contaminants have also been found in fire stations. However, little research characterises the routes via which fire contaminants travel back to fire stations. The UK Firefighter Contamination Survey provides information on firefighters’ PPE provision, decontamination, and storage practices. All serving UK firefighters were eligible to take part in the survey, which comprised 64 questions. A total of 10,649 responses were included for analysis, accounting for roughly 24% of the UK’s firefighting workforce. Results revealed that most firefighters (84%) de-robe contaminated PPE/workwear after re-entering the appliance cab. There was a significant decreasing tendency to send PPE for cleaning after every incident with increasing seniority of role, length of service, and fire attendance frequency. Around one third of firefighters cleaned PPE after every incident. A number of issues were linked to external professional cleaning services, e.g. shrinkage, fit, turn-around time, and stock of reserve/pooled PPE. PPE storage was found to be a potential source of cross contamination, with almost half of firefighters (45%) indicating clean and dirty PPE is not stored separately. More than half of firefighters (57%) stored fire gloves (an item sent for professional decontamination by only 19% of firefighters, and never cleaned by 20%) within other items of PPE such as helmets, boots and tunic/trouser pockets. The survey’s results can be used to target gaps in decontamination measures within UK Fire and Rescue Services.
Associations of green tea, coffee, and soft drink consumption with longitudinal changes in leukocyte telomere length
Authors: Sohn Inhae , Shin Chol , Baik Inkyung 
Published: January 2023

AbstractWhether beverage consumption is associated with longitudinal observation of telomere length remains unclear. We evaluated the association of green tea, coffee, and soft drink consumption with 6-year changes in leukocyte telomere length (LTL). The study included 1952 participants who provided whole blood samples for LTL assays during the baseline (year 2011–2012) and follow-up (year 2017–2018) periods and reported baseline information on consumption of green tea, coffee, and soft drinks. Robust regression analysis was used to analyze the association adjusted for potential confounding variables. In the results, an inverse association between green tea consumption and LTL changes from baseline, which indicate telomere shortening, was found; regression coefficient [95% confidence interval] was − 0.097 [− 0.164, − 0.029] for participants who daily consumed at least 1 cup of green tea compared with non-consumers (p value = 0.006). This association was stronger among women (versus men) and younger participants aged 50–64 years (versus older). However, a positive association between soft drink consumption and LTL shortening was observed among women (p value < 0.05). Coffee consumption was not associated with LTL changes. These findings suggested that green tea consumption may be protective against telomere shortening reflecting biological aging whereas coffee and soft drink consumption may not.