bluuebunny/crossref_metadata_2025_split huggingface dataset:
The impact of surgical case order on short-term and long-term outcomes in patients undergoing laparoscopic gastrectomy: a propensity matched study
Authors: Shao Min , Chen Jun-Yu , Zhong Qing , Qiu Tao-Yuan , Liu Zhi-Yu , Lin Guang-Tan , Tang Yi-Hui , Zheng Li-Na , Wang Jia-Bin , Lin Jian-Xian , Lu Jun , Chen Qi-Yue , Xie Jian-Wei , Li Ping , Zheng Chao-Hui , Huang Chang-Ming 
Published: August 2023

Abstract
Background and aim: Whether the surgical case order is an important factor affecting the short- and long-term outcomes of patients with GC has always been a concern. This study aimed to compare the short- and long-term outcomes of different surgical case orders
Methods: We included patients who underwent laparoscopy-assisted radical gastrectomy at the Union Hospital of Fujian Medical University (Fuzhou, China) between January 2016 and December 2017. In total, 1235 patients (No.1 (n=497), No.2 (n=426), and Other groups (n=312)) were included in the propensity score matching (PSM, 1:1:1).
Results: After PSM, there were no significant differences in clinicopathological characteristics between the No.1, No.2, and the Other groups. The operative duration in the Other group was significantly longer than that in groups No.1 and No.2. The volume of blood loss in the No.2 and the Other group was significantly higher than that in the No.1 group. Kaplan-Meier survival analysis revealed similar five-year overall survival (OS) and disease-free survival (DFS) rates among the three groups. Multivariate Cox regression analysis showed that surgical case order was not independent risk factors for 5-year OS and DFS. Further analysis showed no significant difference in the 5-year OS and DFS among patients with different surgical case orders, regardless of age, pT stage, or range of gastrectomy (P > 0.05).
Conclusions: In high-volume centers, different surgical case orders can only affect operative time and intraoperative bleeding but not short- or long-term outcomes. Surgeons should reasonably schedule surgeries to provide better medical services and to improve patient motivation and care.
Influence of triangle shape fiber in tunnel lining concrete: An innovative approach
Authors: katariwala avni 
Published: August 2023

Abstract
Polypropylene (PP) fibers have properties suitable for reinforcement in concrete. Polypropylene Triangular Polyester Fiber Reinforced Concrete (PPT-PFRC) is a type of fiber reinforced concrete that uses a combination of PP and triangular polyester fibers to enhance the strength and durability of the concrete. The study analyses the properties of hardened concrete and PPT-PFRC mixes to study the axial force, shear force, and bending moment between normal and PPT-PFRC specimens. The researchers are currently attempting to analyze tunnel lining behavior in a static state, although FRC offers more advantages in seismic vibration and blast loading. The goal of this study is to investigate utilization of PPT-PFRC in a tube tunnel to improve the strength of the tunnel. The comparison shows that ordinary concrete has two significant flaws, i.e., poor strength and low strain, however, PPT-PFRC concrete has more toughness and vibration damping.
Prevalence and epidemiological profile of cervical cancer patients attending Nyeri County and Referral Hospital, Kenya: a review of records 2017 – 2022.
Authors: Mbuthia Florence , Gitonga Moses , Mbuthia Beth 
Published: August 2023

Abstract
Introduction
Cervical cancer is the leading cause of cancer mortality in Kenya. This study aimed to establish the prevalence and epidemiological characterization of cervical cancer patients registered in Nyeri County and Referral Hospital, Kenya.
Methods
This was a retrospective observational design that involved the systematic collection and analysis of data from 2328 patient records. Relevant variables, including demographic characteristics, clinical features, treatment modalities and survival outcomes, were extracted and analyzed. Descriptive statistics were used to determine the prevalence of cervical cancer, while Chi-square test was performed to assess the association between various factors and survival outcomes. Multivariate analysis was conducted to control for confounding variables and determine the independent effects of predictors. Ethical clearance was obtained and ethical principles maintained.
Results
Records of 2328 cancer patients were analyzed, out of which 120 were cervical cancer. Majority of cervical cancer patients were aged 50-59 years with majority residing in Nyeri County. The prevalence of cervical cancer was 5.16%. The overall survival rate for cervical cancer patients was 58.33%. Advanced age and late-stage diagnosis were factors associated with lower survival rates.
Conclusions
The study revealed a prevalence of 5.16% of cervical cancer among patients attending Nyeri County and Referral Hospital in Kenya from the year 2017 to 2022 with an overall survival rate of 58.33%. Age and late-stage diagnosis were found to be influential factors in survival outcomes. Therefore, improving early detection and initiation of early treatment for all cervical cancer patients is required in order to improve survival status.
Evaluación del proyecto de saneamiento transfronterizo en Ambos Nogales. Identificando lo homogéneo de lo diverso
Authors: García Ochoa Rigoberto , Zuniga-Teran Adriana , Cervera Gómez Luis Ernesto , Scott Christopher A. , Peña Sergio , Balarezo Vasquez Tomas , Buechler Stephanie , Muñan Valencia Jorge Alberto , Martinez-Molina Karina Guadalupe 
Published: August 2023

Este artículo tiene como objetivo caracterizar a la población de Ambos Nogales en función de sus opiniones sobre los impactos generados por el proyecto de ampliación y evaluación de proyectos de modernización del sistema de saneamiento transfronterizo durante el periodo 2000-2018, para identificar criterios de evaluación ex post que fortalezcan estrategias de gobernanza de políticas públicas en materia de agua y saneamiento. Se aplicó una encuesta aleatoria representativa a nivel ciudad. El análisis de información se realizó mediante el método de conglomerados jerárquicos y el método de análisis de correspondencias múltiples. Los resultados evidencian la conformación de grupos o segmentos de población con alta homogeneidad interna y alta heterogeneidad intergrupal en ambas ciudades, evidencia empírica permite construir una tipología de grupos de población. Como conclusión, se propone una serie de acciones con el objetivo de impulsar una gobernanza transfronteriza y sostenible tendiente a mejorar la opinión pública sobre dicha obra.
Protective Effect of Tertiary Butylhydroquinone against Obesity-induced
Skeletal Muscle Pathology in Post-weaning High Fat Diet Fed Rats
Authors: Zhang Le 
Published: August 2023

Background:
Obesity deleteriously affects skeletal muscle functionality starting from
infancy to adulthood, leading to dysfunctional skeletal muscle.

Objectives:
This study, therefore, evaluated the protective action of tert-butylhydroquinone
(tBHQ) against obesity-induced skeletal muscle pathology in high-fat diet (HFD) fed rats.

Methods:
Twenty post-weaning male albino rats were randomized into four groups of five rats
each as: Group 1 (control), Group 2 (HFD), Group 3 (orlistat) and Group 4 (tBHQ). Group one
received rat pellets for 12 weeks, while groups 2 to 4 received HFD for 12 weeks. At the end of
week 8, obesity was confirmed with Lee Obesity Index and body mass index values of ≥ 303 and
≥ 0.68 gcm2, respectively. Group 3 was given oral administration of orlistat (10 mg/kg, once daily),
while group 4 was given oral administration of tBHQ (25 mg/kg, once daily). Administration
of orlistat and tBHQ commenced from week 9 to the end of the experiment.

Results:
Chronic exposure of post-weaning rats to HFD led to their development of the metabolic
syndrome phenotypes in adulthood, characterized by obesity, hyperglycemia, dyslipidaemia, hyperinsulinaemia,
insulin resistance as well as induction of oxidative stress and alteration of skeletal
muscle markers, which were mitigated following supplementation with orlistat and tBHQ.

Conclusion:
The study showed the anti-obesity potentials of tBHQ and its protective action
against HFD obesity-induced skeletal muscular pathology.
Developmental Neuroendocrinology of Early-Life Stress: Impact on Child
Development and Behavior
Authors: Nicolaides Nicolas C. , Kanaka-Gantenbein Christina , Pervanidou Panagiota 
Published: August 2023

Abstract:
Our internal balance, or homeostasis, is threatened or perceived as threatened by stressful
stimuli, the stressors. The stress system is a highly conserved system that adjusts homeostasis to the
resting state. Through the concurrent activation of the hypothalamic-pituitary-adrenal axis and the locus
coeruleus/norepinephrine-autonomic nervous systems, the stress system provides the appropriate
physical and behavioral responses, collectively termed as “stress response”, to restore homeostasis. If
the stress response is prolonged, excessive or even inadequate, several acute or chronic stress-related
pathologic conditions may develop in childhood, adolescence and adult life. On the other hand, earlylife
exposure to stressors has been recognized as a major contributing factor underlying the pathogenesis
of non-communicable disorders, including neurodevelopmental disorders. Accumulating evidence
suggests that early-life stress has been associated with an increased risk for attention deficit hyperactivity
disorder and autism spectrum disorder in the offspring, although findings are still controversial.
Nevertheless, at the molecular level, early-life stressors alter the chemical structure of cytosines located
in the regulatory regions of genes, mostly through the addition of methyl groups. These epigenetic
modifications result in the suppression of gene expression without changing the DNA sequence. In
addition to DNA methylation, several lines of evidence support the role of non-coding RNAs in the
evolving field of epigenetics. In this review article, we present the anatomical and functional components
of the stress system, discuss the proper, in terms of quality and quantity, stress response, and
provide an update on the impact of early-life stress on child development and behavior.
Assessment of Patient-reported Satisfaction and Metabolic Outcomes Following Initiation of the Second Generation of Flash Glucose Monitoring
in Patients with Type 1 Diabetes
Authors: Al Hayek Ayman , Robert Asirvatham Alwin , Alzahrani Wael M. , Al Dawish Mohamed Abdulaziz 
Published: August 2023

Background and Aims:
This study aims to assess patient-reported satisfaction and metabolic
outcomes following the initiation of the second generation of the Freestyle Libre 2 (FSL2)
system in patients with type 1 diabetes (T1D).

Methods:
This non-randomized single-arm observation study was conducted on 86 patients with
T1D living in Saudi Arabia, who were asked to wear the FSL2 for 12 weeks. The demographic data
were collected at baseline, while the continuous glucose monitoring (CGM) metrics were gathered,
i.e., Glucose Variability (GV) (%), mean Time in Range (TIR), Time Above Range (TAR),
Time Below Range (TBR), and average duration of hypoglycemic events were collected at baseline,
6th week and 12 weeks. Further, the Continuous Glucose Monitoring Satisfaction (CGM-SAT)
was collected at the end of the follow-up.

Results:
Compared to the 6th week, significant differences were observed in the low glucose events
(p = 0.037), % TIR (p = 0.045), and % below 70 mg/dL (p = 0.047) at 12 weeks. Improvement was
seen in the other glucometric variables, but no significant changes were evident (p > 0.05). On
completion of the study period, the ambulatory glucose profile (AGP) metrics showed a 74.3 ±
5.01 (mg/dL) FSL2 hypoglycemia alarm threshold and a 213 ± 38.1 (mg/dL) hyperglycemia alarm
threshold. A majority of the patients stated that CGM-SAT had benefits (mean score > 3.58), although
they felt FSL2 had ‘additional benefits. With regard to the problems with the use of FSL2
majority of the patients stated that FSL2 has minimal discomfort.

Conclusion:
Using second-generation FSL2 in patients with T1D is positively associated with patient-
reported satisfaction and metabolic outcomes.
The Inefficiency of Low-concentration Curcumin Intervention in Ameliorating
Chronic-stage Pulmonary Fibrosis
Authors: Moideen Fathimath Muneesa , Bhandary Yashodhar Prabhakar 
Published: August 2023

Background:
Curcumin, a polyphenol compound, is reported to exhibit ameliorative
effects in acute lung injury and different organ fibrosis models. We have previously demonstrated
that curcumin, at a dose of 75 mg/kg, could modulate inflammatory mediators and fibrinolytic system
proteins in the inflammatory stage as well as fibroproliferative stage in a mouse model of bleomycin
(BLM) induced pulmonary fibrosis. In this study, we investigated the efficacy of the same
dose of curcumin in resolving the established fibrotic stage in a mouse model of BLM-induced
pulmonary fibrosis.

Methods:
We prepared the fibrosis model by intranasal administration of BLM (2 mg/kg). Curcumin
intervention was performed by intraperitoneal injection on 16th to 20th days post BLM exposure.
The control group was administered with normal saline. The mice were sacrificed on the 21st
day post BLM exposure.

Results:
Histological analysis of the lung tissue samples indicated that curcumin (75 mg/kg) could
not reverse the fibrotic features induced by BLM. We also performed RT-PCR and western blot to
examine the molecular changes induced by BLM and curcumin. It was observed that curcumin
could neither reduce the expressions of fibrotic markers nor restore the normal expressions of proteins
in the fibrinolytic system.

Conclusion:
Our data suggest that a low dose of curcumin is not effective in ameliorating the fibrotic
stage of BLM-induced pulmonary fibrosis. An increased dose or a formulation that increases
the bioavailability of curcumin could probably exhibit promising effects against pulmonary fibrosis
in the future.
Inhibition of Ribonucleotide Reductase Induces Endoplasmic Reticulum Stress and
Apoptosis, Leading to the Death of Docetaxel-resistant Prostate Cancer Cells
Authors: Serttas Riza , Erdogan Suat 
Published: August 2023

Background:
The development of chemotherapy resistance in prostate cancer (PCa) patients poses a significant
obstacle to disease progression. Ribonucleotide reductase is a crucial enzyme for cell division and tumor growth.
Triapine, an inhibitor of ribonucleotide reductase, has shown strong anti-tumor activity in various types of cancers.
However, the effect of triapine on docetaxel-resistant (DR) human PCa cells has not been explored previously.

Aim:
This study aimed to examine the potential anti-proliferative effects of triapine in PC3-DR (docetaxel-resistant)
cells.

Methods:
Cell viability was determined by the MTT test, and apoptosis and cell cycle progression were analyzed by
image-based cytometer. mRNA and protein expression were assessed by RT-qPCR and western blot, respectively.

Results:
Triapine administration significantly reduced PC3 and PC3-DR cells' survival, while the cytotoxic effect was
higher in PC3-DR cells. Cell death resulting from inhibition of ribonucleotide reductase was mediated by endoplasmic
reticulum stress, induction of apoptosis, and cell cycle arrest. The findings were supported by the upregulation of
caspases, Bax, Bak, P21, P27, P53, TNF-α, FAS, and FASL, and downregulation of Bcl2, Bcl-XL, cyclin-dependent
kinase 2 (CDK2), CDK4, cyclins, and heat shock proteins expression. According to the data, the reduction of ABC
transporter proteins and NF-ĸB expression may play a role in triapine-mediated cytotoxicity in docetaxel-resistant
cells.

Conclusion:
Based on our findings, triapine emerges as a promising chemotherapeutic approach for combating docetaxel-
resistant prostate cancer.
Analysis of Adherence to anti-PCSK9 Antibody Therapy among Patients from Italy
Authors: Mongiello Paolo , Petti Raffaele , Ciaccia Andrea , Grazia Morgese Maria , Lombardi Renato 
Published: August 2023

Introduction:
Hypercholesterolemia is one of the main risk factors associated with atherosclerotic
cardiovascular disease and coronary heart disease. Statins are the standard cholesterollowering
treatment; however, they have shown, in clinical practice, a reduced adherence to therapy
(<50%) and a modest achievement of the expected outcomes for treatment. This condition prompt
scientific research to develop drugs with different mechanisms of action. In this regard, excellent
results have been achieved with therapeutic use of monoclonal antibodies against PCSK9, enzyme
involved in recycling of Low density lipoprotein receptors (LDLR) on the hepatocytes surface. Indeed,
the reduction in receptor density caused by PCSK9 is associated with increased serum LDL
levels.

Materials and Methods:
After the data extraction of all Local Health Authority (ASL) of Foggia
patients (302) who received, in 2021, at least one administration of Alirocumab or Evolocumab, the
therapeutic adherence was calculated, for each individual patient, by indirect method (calculation of
the Medication Possession Ratio - MPR). According to scientific literature, patients were classified
into: adherents (MPR>80%), average adherents (MPR between 40% and 80%) and non-adherents
(MPR<40%). Patients were then stratified by gender and age groups (0-18, 19-49, 50-64, >65).

Results:
The results show that, for both drugs (Alirocumab and Evolocumab), women are more adherent
than men and the group of young adults (19-49 years old) is the one with the lowest adherence
to therapy, 69% for Alirocumab and 56% for Evolocumab.

Conclusion:
According to Italian Drug Agency (AIFA), poor therapeutic adherence is the main
cause of ineffectiveness of drug therapies, and it is associated with increased hospitalizations, morbidity
and mortality. Data obtained from this study allow to detect the categories of patients who
need specific programs about the correct use of drugs, in order to increase therapeutic adherence and
facilitate the achievement of the expected outcomes for treatment.
Ergonomic Evaluation and Design of Workstation for Gemstone Polishing
Workers
Authors: Bhore Mohit B. , Shaikh Saddam , Meena Makkhan L. 
Published: August 2023

Background:
Many researchers have stated that workers working in unorganized sectors
are at risk of musculoskeletal disorders (MSDs), like back pain, wrist pain, pain in the neck
and shoulders, etc. Ergonomic study of these workstations is necessary for the analysis of workrelated
disorders.

Methods:
In this study on MSDs among gemstone workers in Jaipur, Rajasthan; a modified Nordic
questionnaire was employed. Further analysis was done using the 'Ergonomic Design and
Analysis’ module of DELMIA. Rapid Upper Limb Assessment (RULA) analysis was used.

Results:
The survey showed lower back pain among 81.25% of workers. Neck pain, hips or thigh
pain, and ankle or feet pain were observed among nearly half of the surveyed workers, leading to
further investigation. RULA analysis confirmed the results of the survey; the final RULA score
came out to be 7. This score means investigation and changes are needed immediately. The
workstation was designed using standard anthropometric data for the Indian population and modeled
in CATIA. The modified workstation was analyzed using DELMIA, which has shown a
RULA score of 3.

Conclusion:
The survey results and RULA analysis in DELMIA of gemstone polishing workers
have shown that gemstone polishing is a highly risky profession. Musculoskeletal risk factors,
like low back pain, neck pain, and wrist pain, have also been found to be present among the
workers. The gemstone polishing workstation needs design interventions using Indian anthropometric
data to reduce the risk of musculoskeletal disorders. RULA analysis of an anthropometrically
modified workstation showed the modified workstation to be ergonomically fit.
Диполярные биэкситоны в латеральных ловушках в гетероструктурах Si/SiGe/Si
Authors: Цветков В.А. , Бурбаев Т.М. , Сибельдин Н.Н. , Мартовицкий В.П. , Скориков М.Л. , Ушаков В.В. 
Published: August 2023

Si/SiGe/Si heterostructures with long-range lateral potential fluctuations that appear in the capping Si layer near the SiGe/Si heterointerface due to the presence of relaxed areas in the SiGe layer have been studied. Analysis of the low-temperature photoluminescence spectra indicates that, upon the photoexcitation of the structure, the accumulation of nonequilibrium charge carriers, formation of dipolar excitons, and their recombination take place in large-scale lateral traps formed by these fluctuations. It is found that, at temperatures T < 10 K, a new narrow line appears with an increase in the excitation level at the blue side of the broad photoluminescence band of dipolar excitons localized by short-range potential fluctuations. At temperatures T ~ 2 K, this line is dominant in the spectra even at the lowest excitation levels. It is shown that, at moderate excitation levels, this line is caused by the recombination of free dipolar biexitons in large-scale traps. At high excitation levels, the width of the new line increases by more than a factor of 2 compared to that at lower excitation levels, and under these conditions this line is associated with the recombination of dipolar electron–hole plasma in large-scale traps.
ENVIRONMENTAL-BASED STUDENT WORKSHEETS DESIGN FOR ECONOMICSS SUBJECTS IN SENIOR HIGH SCHOOL
Authors: Febianti Yopi Nisa , Nurkholis Meli 
Published: August 2023

This study aims to identify the activities of the tofu and tempeh industry that can be used as a source of economics learning in senior high school, and how the design of environmental-based student worksheets. This study uses a qualitative method that is carried out on tofu and tempeh craftsmen in Cisambeng Village, Majalengka Regency. The subjects in this study were the community of tofu and tempeh craftsmen. The data collection techniques in this study are participatory observation, in-depth interviews, documentation, also interview instruments, observation instruments, recordings, and cameras are used. The data analysis technique in this study uses the Miles and Huberman model which includes data collection, data reduction, data presentation, and drawing conclusions. The results of this study indicate that various economics activities can be found in the tofu and tempeh industry in Cisambeng Village, Majalengka Regency which can be used as learning resources in economics subjects in senior high school. Suggestions for other researchers are to be able to continue this research in terms of utilizing environmental-based learning resources in the form of Students’ worksheets in order to assist in the process of learning economics