bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tour leaders and guides’ multiple mentoring functions: scale development and validation
Authors: Huang Wen-Shiung , Lin Yung-Sen , Tsao Chiung-Lin 
Published: June 2023

Purpose
Based on the mentoring literature, this study aims to explore the mentoring functions developed by the travel industry and develop a multiple mentoring function scale (MMFS) for tour leaders.

Design/methodology/approach
Study One of this research involved in-depth interviews with 23 tour leaders for establishing the initial question bank and pilot test scale. In Study Two, the initial scale was pilot tested by 225 tour leaders for identifying the factor structure through exploratory factor analysis. In Study Three, the model was verified through confirmatory factor analyses of 251 calibration samples. In Study Four, cross-validation was verified by 227 validation samples.

Findings
In Study One, through the content analyses, an initial question bank of 51 questions was established. The question bank was reviewed by 15 experts, resulting in the development of a pilot test scale of 36 questions. In Study Two, 16 questions were retained after the initial scale was pilot tested, and four dimensions were identified, including career competency, reverse mentoring, career development and psychosocial functions. In Study Three, the model was verified through confirmatory factor analyses and confirmed to have good reliability and construct validity. Finally, a first-order, four-factor scale that consisted of 16 questions was established. In Study Four, cross-validation was verified.

Research limitations/implications
MMFS establishment underwent a rigorous development process, and the scale’s reliability and validity are supported. It is suggested that future research should develop and construct a multifunctional model for tour-leading professionals based on the MMFS to evaluate the long-term impact of the MMFS.

Originality/value
Previous studies have mainly focused on typical mentoring functions. Multiple mentoring functions derived from the characteristics of tour leaders and guides have rarely been discussed. This research can fill the gap in the application of mentoring system to human resource management research in the tourism industry. As a result, this four-dimensional multiple mentoring functions scale provides a progressive perspective and be regarded as the first version of the scale development in the tourism industry.
Voice Markers in Septuagint Greek in the Light of Hebrew Interference: A Corpus‐Based Study on the Aorist System of the Book of Genesis*
Authors: Dahl Eystein , Tronci Liana 
Published: June 2023

AbstractIn this paper, we examine the behaviour of so‐called passive and middle aorist forms in the Greek reflected in the Genesis of the Septuagint. The Septuagint, and Biblical Greek more generally, displays a considerable aberration with respect to other varieties of Ancient Greek regarding the relative frequency of passive vis‐à‐vis middle aorist forms. Here, we explore this feature of Septuagint Greek in some detail, showing that there is a more or less consistent, binary system at this stage, where the passive aorist is the preferred expression of monoargumental detransitive clauses, while the middle primarily appears in biargumental detransitive clauses. A comparison with the original text in Biblical Hebrew suggests that its binyanim system, with systematic distinction between transitive and detransitivising stems, may have played a key role in accelerating this process, which was already present in earlier stages of Greek. This process resulted in a general ousting of the aorist middle, which essentially became a lexically restricted variant of the active voice.
The contribution of hypertensive disorders of pregnancy to late preterm and term admissions to neonatal units in the UK 2012–2020 and opportunities to avoid admission: A population‐based study using the National Neonatal Research Database
Authors: Conti‐Ramsden Frances , Fleminger Jessica , Lanoue Julia , Chappell Lucy C. , Battersby Cheryl ,   the UK Neonatal Collaborative
Published: June 2023

AbstractObjectiveTo quantify maternal hypertensive disorder of pregnancy (HDP) prevalence in late preterm and term infants admitted to neonatal units (NNU) and assess opportunities to avoid admissions.DesignA retrospective population‐based study using the National Neonatal Research Database.SettingEngland and Wales.PopulationInfants born ≥34 weeks’ gestation admitted to NNU between 2012 and 2020.MethodsOutcomes in HDP infants are compared with non‐HDP infants using regression models.Main outcome measuresHypertensive disorder of pregnancy, primary reason for admission, clinical diagnoses and resource use.Results16 059/136 220 (11.8%) of late preterm (34+0 to 36+6 weeks’ gestation) and 14 885/284 646 (5.2%) of term (≥37 weeks’ gestation) admitted infants were exposed to maternal HDP. The most common primary reasons for HDP infant admission were respiratory disease (28.3%), prematurity (22.7%) and hypoglycaemia (16.4%). HDP infants were more likely to be admitted with primary hypoglycaemia than were non‐HDP infants (odds ratio [OR] 2.1, 95% confidence interval [CI] 2.0–2.2, P < 0.0001). 64.5% of HDP infants received i.v. dextrose. 35.7% received mechanical or non‐invasive ventilation. 8260/30 944 (26.7%) of HDP infants received intervention for hypoglycaemia alone (i.v. dextrose) with no other major intervention (respiratory support, parenteral nutrition, central line, arterial line or blood transfusion).ConclusionsThe burden of maternal HDP on late preterm and term admissions to NNU is high, with hypoglycaemia and respiratory disease being the main drivers for admission. Over one in four were admitted solely for management of hypoglycaemia. Further research should determine whether maternal antihypertensive agent choice or postnatal pathways may reduce NNU admission.
Investigation of the effects of pelvic floor training on pain, sexual dysfunction, and quality of life in female patients with primary Sjögren syndrome
Authors: Kurt Kadriye Tugce , Cetin Sebahat Yaprak , Ayan Ayse 
Published: June 2023

AbstractAimTo investigate the effects of pelvic floor training on pain, sexual dysfunction and quality of life in female patients with primary Sjögren syndrome (pSS) and determine whether pelvic floor training was superior to an education program.MethodsForty‐six pSS patients (all women) with an average age of 47.78 ± 9.18 years were included in the study. Patients were divided into two groups as a pelvic floor training group and control group for 8 weeks. Visual Analog Scale (VAS), Pelvic Pain Impact Questionnaire (PPIQ), Female Sexual Function Scale (FSFI), Health Assessment Questionnaire (HAQ), Pelvic Floor Disability Index‐20 (PFDI‐20), and Pelvic Floor Impact Questionnaire (PFIQ‐7) were used to evaluate the outcomes. All evaluations were performed at baseline and at the end of the 8th week.ResultsWhen the groups were compared before training, there was no significant difference (p > .05). In post‐training comparisons, there were significant differences in VAS, PPIQ, FSFI, PFIQ‐7, and PFDI‐20 in the pelvic floor training group (pvalues between .02 and .00), and in FSFI‐lubrication, PFIQ‐7, and PFDI‐20 (pvalues between .00 and .03) in the control group. According to Δ values, the pelvic floor training group was found to be superior in terms of FSFI orgasm, pain, and lubrication scores (p = .00) and all sub‐parameters of PFDI‐20 (p = .00).ConclusionPelvic floor training has a positive effect on the sexual dysfunction and discomfort caused by pelvic symptoms in patients with pSS. Pelvic floor training should be included in rehabilitation programs to improve sexual function and pelvic floor dysfunctions for patients with pSS.
Cetuximab enhances radiosensitivity of esophageal squamous cell carcinoma cells by G2/M cycle arrest and DNA repair delay through inhibiting p‐EGFR and p‐ERK
Authors: Zhao Guifang , Feng Liwen , Ye Ting , Liu Yanshen , Fan Li , Ye Chengzhi , Chen Jing 
Published: June 2023

AbstractBackgroundAlthough radiotherapy has improved local control in esophageal squamous cell carcinoma (ESCC), a considerable number of patients still experience relapse due to resistance. In this study, we aimed to evaluate the effects of cetuximab on radiosensitivity in two ESCC cell lines (ECA109 and TE‐13) and to investigate their underlying mechanisms.MethodsCells were pretreated with or without cetuximab before irradiation. The MTT assay and clonogenic survival assay were performed to evaluate cell viability and radiosensitivity. Flow cytometry was performed to analyze cell cycle distribution and apoptosis. The γH2AX foci were counted to determine cellular DNA‐repairing capacity via immunofluorescence assay. The phosphorylation of key molecules involved in the epidermal growth factor receptor (EGFR) signaling pathway and DNA double‐strand break (DSB) repair were measured by western blot.ResultsCetuximab alone was not sufficient to suppress cell viability, but significantly enhanced radiation‐induced inhibition of clonogenic survival in ECA109 and TE‐13. The radiation sensitivity enhancement ratio (SER) was 1.341 and 1.237 for ECA109 and TE‐13, respectively. ESCC cells treated with cetuximab were arrested at the G2/M phase in response to radiation. No significant increase in apoptotic rate was observed in irradiated cells that were treated with cetuximab. The average number of γH2AX foci increased in the combination group (cetuximab and radiation). Cetuximab suppressed phosphorylation of EGFR and downstream ERK, but had no significant effect on AKT.ConclusionsThese results indicate the potential for use of cetuximab as an effective radiosensitizer in ESCC. Cetuximab promotes G2/M cycle arrest and reduces DSB repair, as well as inhibiting EGFR and downstream ERK pathways in ESCC.
Pulmonary artery occlusion post immunotherapy for hilar node‐positive lung cancer
Authors: Tada Makoto , Uehara Hirofumi , Ohyu Takeshi , Watanabe Atsushi 
Published: June 2023

AbstractWe present the case of a patient who developed pulmonary artery occlusion following immune‐checkpoint inhibitor (ICI) therapy for non‐small cell lung cancer. A 69‐year‐old man with squamous cell carcinoma (yc‐T1cN0M0), initially diagnosed at c‐stage IVA (T3N1M1b), in the upper lobe of the left lung, was scheduled to undergo salvage lung resection after ICI therapy. However, he exhibited an occlusion of the lingular pulmonary artery near the clinically metastatic hilar lymph node. To avoid severe adhesions, the patient underwent successful wedge resection without dividing pulmonary vessels and was discharged without complications. Surgeons should be prepared for pulmonary artery changes following ICI therapy.
Circ_0008285 silencing suppresses angiotensin II‐induced vascular smooth muscle cell apoptosis in thoracic aortic aneurysm via miR‐150‐5p/BASP1 axis
Authors: Zhang Leilei , Zhao Ziniu , Quan Xiaoqiang , Xie Zhouliang , Zhao Jian 
Published: June 2023

AbstractBackgroundVascular smooth muscle cells (VSMCs) are the predominant cell type of the aortic middle layer, the abnormal number or function of which has been demonstrated to have a role in thoracic aortic aneurysm (TAA). Here, this study aimed to identify the function of circ_0008285 in VSMC apoptosis.MethodsHuman VSMCs were treated with angiotensin II (Ang II) for functional experiments. Cell counting kit‐8, 5‐ethynyl‐2′‐deoxyuridine (EdU), and flow cytometry were applied for function analysis. The interaction between miR‐150‐5p and circ_0008285 or brain acid‐soluble protein 1 (BASP1) was also evaluated by dual‐luciferase reporter assay and RNA immunoprecipitation assay. Exosomes were isolated by the commercial kit.ResultsA highly expressed circ_0008285 was observed in the aortic tissues of TAA patients and Ang‐II‐induced VSMCs. Circ_0008285 deficiency dramatically reversed Ang‐II‐induced proliferation arrest and apoptosis promotion in VSMCs. Circ_0008285 functionally targeted miR‐150‐5p. MiR‐150‐5p inhibition attenuated the inhibitory effects of circ_0008285 silencing on Ang‐II‐evoked apoptosis in VSMCs. BASP1 was verified to be a target of miR‐150‐5p, and was proved to attenuate miR‐150‐5p‐triggered apoptosis arrest in Ang‐II‐stimulated VSMCs. Additionally, extracellular circ_0008285 was packaged into exosomes, which could be transferred into the recipient cells.ConclusionCirc_0008285 silencing could suppress Ang‐II‐induced VSMCs apoptosis via miR‐150‐5p/BASP1 axis, adding further understanding of the pathogenesis of TAA.
Insight toward inflammasome complex contribution to male infertility
Authors: Minas Aram , Costa Lucas Vasconcelos Soares , Miyazaki Mika Alexia , Antoniassi Mariana Pereira 
Published: June 2023

AbstractDuring the last decades, a wide range of factors involved in the physiopathology of male infertility disease have been discussed. The inflammation role in some of the main infertility‐related diseases has been studied, such as varicocele, spinal cord injury and obesity. Inflammation is the main response of the immune system to infection or cell damage, leading to intense inflammatory cytokine release during the loss of homeostasis. One of the first steps toward pro‐inflammatory cytokines release is the recognition of dangerous signals by the immune cells, including pathogen‐associated molecular patterns (PAMPs) and damage‐associated molecular patterns (DAMPs). These molecules can activate an important multiprotein complex, called inflammasome. Although these complexes have been studied during the last decades, their participation in male infertility has gained attention recently. Considering the inflammasome complex's high potential to be targeted for drug therapy, this review tries to shed light on current literature. Therefore, in the current review paper, we aimed to discuss the inflammasome complex activation, involvement in different male infertility conditions, and localization in the male reproductive tract.
Controlling Nutritional Status (CONUT) score as a prognostic marker for gastrointestinal stromal tumours
Authors: Sui Chao , Lin Chen , Tao Tingting , Huang Yibo , Zhang Haoran , Yu Heng , Tao Liang , Wang Meng , Wang Feng 
Published: June 2023

AbstractBackgroundThe Controlling Nutritional Status (CONUT) score, regarded as the effective indicator of patient nutrition, has been demonstrated to be related to prognosis of numerous tumours. Nevertheless, the significance of CONUT for gastrointestinal stromal tumour (GIST) remains unclear. This study intended to clarify the association between CONUT and the prognosis of GISTs.MethodsThree hundred and fifty‐five patients with GISTs undergoing surgical resection at our center were retrospectively assessed. Receiver operating characteristic curve analysis was used to help determine the cut‐off value of CONUT score. Relapse‐free survival (RFS) and overall survival (OS) were assessed by Kaplan–Meier curve analysis. Prognostic factors for RFS and OS were examined by Cox proportional hazards models.ResultsA total of 355 patients were enrolled in this study. Areas under the curve (AUC) were 0.638 for CONUT score, and the cut‐off value of CONUT was shown to be three. Kaplan–Meier curve analysis showed that high CONUT score was linked to poorer RFS and OS. Univariate and multivariate analyses ultimately revealed that CONUT was a risk factor for RFS and OS, independent of demographics and clinicopathological tumour characteristics.ConclusionsCONUT score was an effective and novel predictor for prognosis of GIST patients treated with surgery, indicating its potential as a prognostic marker in the overall management.
The length of hospital stay following bariatric surgery in Australia: the impact of patient, procedure, system and surgeon
Authors: Chadwick Chiara , Burton Paul R. , Brown Dianne , Holland Jennifer F. , Campbell Angus , Cottrell Jenifer , Reilly Jennifer , MacCormick Andrew D. , Caterson Ian , Brown Wendy A. 
Published: June 2023

AbstractBackgroundThe length of a patient's stay (LOS) in a hospital is one metric used to compare the quality of care, as a longer LOS may flag higher complication rates or less efficient processes. A meaningful comparison of LOS can only occur if the expected average length of stay (ALOS) is defined first. This study aimed to define the expected ALOS of primary and conversion bariatric surgery in Australia and to quantify the effect of patient, procedure, system, and surgeon factors on ALOS.MethodsThis was a retrospective observational study of prospectively maintained data from the Bariatric Surgery Registry of 63 604 bariatric procedures performed in Australia. The primary outcome measure was the expected ALOS for primary and conversion bariatric procedures. The secondary outcome measures quantified the change in ALOS for bariatric surgery resulting from patient, procedure, hospital, and surgeon factors.ResultsUncomplicated primary bariatric surgery had an ALOS (SD) of 2.30 (1.31) days, whereas conversion procedures had an ALOS (SD) of 2.71 (2.75) days yielding a mean difference (SEM) in ALOS of 0.41 (0.05) days, P < 0.001. The occurrence of any defined adverse event extended the ALOS of primary and conversion procedures by 1.14 days (CI 95% 1.04–1.25), P < 0.001 and 2.33 days (CI 95% 1.54–3.11), P < 0.001, respectively. Older age, diabetes, rural home address, surgeon operating volume and hospital case volume increased the ALOS following bariatric surgery.ConclusionsOur findings have defined Australia's expected ALOS following bariatric surgery. Increased patient age, diabetes, rural living, procedural complications and surgeon and hospital case volume exerted a small but significant increase in ALOS.Study typeRetrospective observational study of prospectively collected data.
Blood analysis for screening of electrolyte and kidney function alterations in patients with febrile urinary tract infection
Authors: González‐Bertolín Isabel , Barbas Bernardos Guillermo , García Suarez Leire , Martín Espín Irene , Barcia Aguilar Cristina , López López Rosario , Calvo Cristina 
Published: June 2023

AbstractAimTo describe the prevalence, severity, risk factors, and clinical relevance of electrolyte disturbances and acute kidney injury (AKI) during febrile urinary tract infection (fUTI).MethodsRetrospective observational study of well/fair‐appearing patients between 2 months and 16 years, with no previous relevant medical history, diagnosed with fUTI in the paediatric emergency department (PED) with subsequent microbiological confirmation. Analytical alteration (AA) data were considered: AKI (creatinine elevation × 1.5 the median for age), plasma sodium alteration (≤130 or ≥150 mEq/L), and potassium alteration (≤3 or ≥6 mEq/L).ResultsWe included 590 patients, 17.8% presented AA (13 hyponatremia, 7 hyperkalaemia, and 87 AKI). No patient presented severe analytic alterations or a higher frequency of symptoms potentially attributable to these alterations (seizures, irritability, or lethargy). Risk factors associated with these AA were clinical dehydration (OR = 3.5 95% CI: 1.04–11.7; p = 0.044) and presenting a temperature >39°C (OR = 1.9 95% CI: 1.14–3.1; p = 0.013).ConclusionsElectrolyte and renal function disturbances are infrequent in the previously healthy paediatric population with a fUTI. If present, they are asymptomatic and not severe. Based on our results, performing systematic blood analysis to rule out AA appears no longer justified, especially in the absence of risk factors.
Pharmacogenetics and pharmacokinetics of tamoxifen in a Zimbabwean breast cancer cohort
Authors: Mbavha Bianza Tinotenda , Thelingwani Roslyn Stella , Chikwambi Zedias , Nyakabau Anna Mary , Masimirembwa Collen ,   and the Consortium for Genomics and Therapeutics in Africa
Published: June 2023

AbstractTamoxifen is the most used hormonal therapy for oestrogen receptor‐positive breast cancer. CYP2D6 is the main enzyme in the metabolic pathway of tamoxifen to endoxifen. Variations in endoxifen plasma concentrations are associated with CYP2D6 polymorphisms. This study aimed to determine the association between the CYP2D6 polymorphisms and endoxifen plasma concentrations in a cohort of Zimbabwean breast cancer patients (n = 40). TaqMan genotyping and copy number assays were done to determine CYP2D6 genotypes. Tamoxifen and metabolites were quantitated using LC‐MS/MS. The population had high frequencies of the CYP2D6 reduced function alleles, *17 (15%) and *29 (18%). The median endoxifen concentration was 4.78 ng/mL, and in 55% of the patients, mostly intermediate metabolizers were below the endoxifen therapeutic threshold of 5.97 ng/mL. The CYP2D6 phenotypes and activity scores were significantly associated with endoxifen plasma concentrations (P = 0.0151) and with endoxifen to N‐desmethyl‐tamoxifen ratios (P = 0.0006).
Contextual and individual barriers to providing practice leadership by frontline managers in community services for adults with intellectual disabilities: A qualitative study
Authors: Deveau Roy , Rickard Georgina 
Published: June 2023

AbstractBackgroundAs practice leaders, frontline managers observe staff working, provide feedback and use organisational structures to improve staff skills and focus on service‐user quality of life. This qualitative study explored the experiences and barriers for frontline managers providing practice leadership to staff in community services for adults with learning disabilities.MethodsAudio‐recorded data was collected during semi‐structured interviews with 14 frontline managers, transcribed and analysed using thematic analysis.FindingsThree themes emerged reflecting participants' experiences of barriers to their work as practice leaders, focusing on stable staff teams, ‘admin’ and paperwork, and developing staff, each with sub‐themes.ConclusionsResults reflect existing research and suggest new challenges relating to progress in personalisation. Frontline managers experience barriers to providing practice leadership due to contextual and individual factors described in the themes. Successful implementation of policy initiatives, for example, Transforming Care requires further research on the impact, development and provision of practice leadership for support staff. should recognise these factors influencing frontline managers and ensure suitable policies and training to support practice leadership.
The development of commitment: Attention for intention
Authors: Zhai Shuyi , Cheng Shaozhe , Moskowitz Naomi , Shen Mowei , Gao Tao 
Published: June 2023

AbstractAdhering to a partially defined plan requires an intentional commitment that curbs distracting desires conflicting with the planned course of action, enabling humans to act coherently over time. Two studies (N = 50, 27 girls, ages 5–6, Han Chinese, in Hangzhou, China, 2022.02–2022.03) explored the development of commitment to partial plans in a sequential decision‐making task and the underlying cognitive capacity focusing on its correlation to attentional control. Results suggest that only 6‐year‐olds committed to partial plans (d = .51), and children's commitment ratio was positively correlated with the use of proactive control (r = .40). These findings indicate that intentional commitment does not develop simultaneously with intention understanding, but rather matures gradually with the development of attentional control.