bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cocktail therapy of combined SGLT2 inhibitor, entresto and adipose-derived mesenchymal stem cells effectively prevents abdominal aortic aneurysmal associated complication syndrome in rodent
Authors: Sheu Jiunn-Jye , Yeh Jui-Ning , Ko Sheung-Fat , Chen Yi-Ling , Sung Pei‐Hsun , Yip Hon‐Kan 
Published: July 2023

Abstract
Background
This study tested that triple combination therapy [Dapagliflozin + Entresto + adipose-derived mesenchymal stem cells (ADMSCs)] offered additional benefits on preventing abdominal aortic aneurysm (AAA) against AAA complication syndrome (defined as AAA dilatation, muscle layer destruction and inflammation) in rodent.
Methods and Results
Adult-male SD rats (n = 54) were equally categorized into group 1 (sham control), group 2 (AAA only), group 3 [AAA + dapagliflozin (20 mg/kg/day orally from days 7 to 28 after AAA induction)], group 4 [AAA + entresto (100 mg/kg/day orally from days 7 to 28 after AAA induction)], group 5 [AAA + ADMSCs (1.0 x 106 cells) by intravenous administration since day 7 after AAA induction for 3 consecutive dosages at 3-day interval)] and group 6 (AAA + combined dapagliflozin-Entresto-ADMSCs). The result showed that the AAA diameter at day-28 was smallest in group 1, biggest in group 2, significantly increased in group 4 than in groups 3/5/6 and significantly increased in groups 4/5 than in group 6, but it showed no difference between groups 4/5 (all p < 0.0001). The light microscopic findings demonstrated that the AAA intimal thickness (i.e., indicator of intimal hyperplasia)/fibrotic area/numbers of immune-inflammatory (CD3+/CD4+/MMP2+/MMP9+) cells displayed an identical pattern, whereas the integrity of laminar structure of AAA medial-muscle layer/number of small vessels exhibited an opposite pattern of AAA diameter among the groups (all p < 0.0001). The protein expressions of inflammation (TNF-α/IL-1β/IL-6/MMP-2/MMP-9)/fibrosis (TGF-β/Smad3)/apoptosis (cleaved-Caspase3/cleaved-PARP) displayed an identical pattern, whereas the protein expressions of tissue inhibitors of metalloproteinases (TIMP1/TIMP2) displayed an opposite pattern of AAA diameter among the groups (all p < 0.0001).
Conclusion
The results of the present study support that triple therapy with DAPA + entresto + ADMSCs could be innovative therapeutic modality for AAA setting.
SIRT4 Overcomes 5-Fluorouracil Associated Chemoresistance by Inhibiting Autophagy through Inhibition of ammonia production
Authors: Xu Bo , Cai Xiaojing , Xiao Hua , Huang Guoyu 
Published: July 2023

Abstract
5-Fluorouracil (5-FU) is a first-line chemotherapy agent for colorectal cancer (CRC), but the emergence of chemoresistance has affected its use. Our preliminary results found that SIRT4 levels were reduced in CRC and correlated with poor prognosis. Here, we show that SIRT4 enhances the sensitivity of CRC cells to 5-FU. Mechanistically, SIRT4 inhibits autophagy flow in CRC cells, and, inhibition of autophagy by bafilomycin or shATG5 counteracts the increased sensitivity of CRC cells to 5-FU caused by SIRT4. Further, SIRT4 inhibited glutamine metabolism and thus ammonia production in CRC cells by inhibiting glutamate dehydrogenase (GDH), whereas inhibition of glutamine metabolism by BPTES or addition of ammonium chloride to the medium counteracted the inhibition of autophagy caused by SIRT4. Finally, inhibition of glutamine metabolism or addition of ammonium chloride to the medium counteracted the difference in sensitivity of CRC cells to 5-FU caused by SIRT4. Together, the current findings identify a novel role of SIRT4 in autophagy manipulation and demonstrate the molecular mechanism behind SIRT4 in enhancing the sensitivity of colorectal cancer cells to 5-FU, providing a promising strategy to increase the efficacy of 5-FU for the treatment of colorectal cancer.
Aggression, exposure to violence, opportunity factors, and school bullying perpetration among Hong Kong early adolescents
Authors: Siu Cheuk Lap Jacky , Zhong Hua , Wong Sing-Wing Dennis 
Published: July 2023

Abstract
Extensive studies have identified the predictive effect of aggression on school bullying. Despite those efforts, there is a paucity of research examining the underlying mechanisms of the aggression-bullying relationship. Drawing on the notion of social network analysis, this study argues that exposure to violence may explain the aggression-bullying association, whereas the mediating effect of exposure to violence may be conditioned by three opportunity factors (neutralization of use of violence, family harmony, and positive school climate). Data used in this study were derived from a questionnaire survey with a school-based random sample of 2,976 Hong Kong early adolescents (aged 10 to 14). The findings of mediation and moderated mediation analyses indicated that reactive aggression, proactive-power related aggression, and proactive-affiliation related aggression have predictive effects on school bullying perpetration. Besides, this study provided solid support for the mediating role of exposure to violence on the aggression-bullying relationship. Moreover, the results revealed that the neutralization technique “defense of necessity” aggravates the indirect effect of aggression on bullying, whereas limited support was granted for the mitigating effect of family harmony and positive school climate. Limitations and policy implications are discussed.
IPCC Tier 1 methodology overestimates the carbon footprint of smallholder cattle production systems in Kenya
Authors: Korir Daniel , Ndung'u Phyllis , Onyango Alice , Marquardt Svenja , Arndt Claudia , Goopy John , Eckard Richard 
Published: July 2023

Abstract
Most Sub-Saharan countries still rely on the basic Intergovernmental Panel on Climate Change's (IPCC) Tier 1 methodology for reporting greenhouse gas (GHG) emissions from their livestock sector. This approach is, however, associated with high uncertainty and cannot detect changes in GHG emissions resulting from mitigation interventions. The present study aimed to quantify the effect of replacing the IPCC Tier 1 methodology with Tier 2 approaches in assessing total farmgate GHG emissions and products' emission intensities (EIs) in smallholder cattle production in Western Kenya. Additionally, the study assessed the effect of using locally measured methane yield (MY) instead of regional defaults in Tier 2 estimations. A partial life cycle assessment (LCA) was conducted using aggregated activity data from two contrasting study sites, one with moderately performing and another with low-performing cattle production systems. The total farmgate GHG emissions were allocated to the co-products, namely milk and live weight gain, using the novel energy expenditure allocation method, in comparison to the traditionally used protein mass allocation. Compared Tier 1 methodology, the use of Tier 2 approaches resulted in 18-44% lower total farmgate GHG emissions and milk EIs across the two study sites. When the IPCC regional MY default was substituted with locally measured MY, the total GHG emissions and milk EI increased by 19-25%. These findings suggest that the continued use of IPCC Tier 1 methodology or Tier 2 MY defaults by East African countries are resulting in considerable uncertainty in their livestock GHG inventory reporting. There is therefore a need for these developing nations to adopt higher-tier methodologies as well as measure and utilize locally relevant MY for more accurate inventory reporting and to be able to assess suitable GHG mitigation strategies for local cattle production systems. Additionally, the study found that the energy expenditure allocation method apportioned a lower proportion of GHG emissions to milk production compared to live weight gain, reflecting the greater nutrient use efficiency by cattle in producing milk than gaining weight. As developing countries are faced with the double challenge of increasing animal-sourced food to feed the growing population and a need to reduce GHG emissions associated with food production, it is sensible for these countries to report changes in product EIs rather than absolute emissions. It is, therefore, imperative to continually refine LCA methodology for more relevance in multifunctional smallholder systems for unbiased measurement of products' EIs from such systems.
Modelling the Dynamics of Information Warfare: An Attacker-Defender Scenario Using Lotka-Volterra Equations
Authors: Pandey Rashmikiran , Pandey Mrinal , Nazarov Alexey 
Published: July 2023

Abstract
The dynamics of information warfare in an attacker-defender scenario pose significant challenges in today's digital age. To address these challenges, this research proposes a model based on the modified Lotka-Volterra equations, originally developed for predator-prey interactions in ecological systems, to analyze and simulate the population dynamics of attackers and defenders in information warfare. The model captures the growth, interaction, and feedback loop between the attacker and defender populations, allowing for a comprehensive understanding of their dynamics over time. In this model, the attacker equation incorporates parameters for the attacker's growth rate and the impact of defenders on attackers. Similarly, the defender equation considers the defender's natural decline rate and the influence of attackers on defenders. By discretizing time into small intervals and employing Euler's method, the model enables real-time simulation of the attacker-defender scenario. The simulation spans a time interval of 100 units, providing insights into the population dynamics and equilibrium points of the attacker and defender populations. The research findings highlight the model's effectiveness in capturing the dynamics of information warfare. The simulation results showcase the initial growth of the attacker population, followed by a decline as defenders implement effective countermeasures. Conversely, the defender population grows and stabilizes as their defensive capabilities improve. The research contributes to the growing body of knowledge in information warfare and provides insights for the development of robust defence strategies.
Zagreb Topological Properties of Hexa Organic Molecular Structures
Authors: Iqbal Javaria , Salman Muhammad 
Published: July 2023

Background:
In connection with the study of chemical graph theory, it has been explored that a single number can capture the numerical representation of a molecular structure, and this number is known as a topological property (index).

Objective:
This study aimed to explore a few Zagreb topological properties for four hexa organic molecular structures (hexagonal, honeycomb, silicate, and oxide) based on the valency and valency sum of atoms in the structure.

Methods:
We employed the technique of partitioning the set of bonds according to the valency and valency-sum of end atoms of each bond and then performed the computation by using combinatorial rules of counting (that is, the rule of sum and the rule of product). The obtained results were also compared numerically and graphically.

Results and Conclusion:
Exact values of five valencies based and five valency-sum-based Zagreb topological properties were found for the underline chemical structures.
Problematika dan Solusi Pendidikan Berbasis Multikultural di Era Globalisasi dan Modernisasi
Authors: Hidayat Rahmat , Setiawan Agung , Juliana Kanisa Ayu 
Published: July 2023

<p class="abstrak">Dewasa ini umat Islam menghadapi banyak tantangan yang serius, terutama dalam bidang dunia pendidikan terutama di era globalisasi dan modernisasi. Salah satu tantangan tersebut adalah maraknya Pendidikan berbasis Multikulturalisme. Hasil penelitian menunjukkan Islam memiliki konsep-konsep yang berdasarkan pada <em>worldview</em>-nya sendiri, seperti: Konsep Tuhan, kebenaran, ilmu, manusia, dan kebahagiaan. Sementara dalam penerapan konsep-konsep <em>worldview</em> Islam, berbeda dengan <em>worldview</em> Barat. Hal ini serupa dengan Pendidikan Multikulturalisme yang banyak menerapkan unsur-unsur ideologi dari <em>worldview</em> Barat, seperti: Pluralisme, humanisme, relativisme, dan pragmatisme. Maka, dalam hal tersebut banyak ditemukan problematik pemikiran yang bertentangan dengan <em>worldview</em> Islam. Sehingga, proses penerapan pendidikan terutama agama yang berbasis multikulturalisme, tidak sesuai dengan tradisi masyarakat Islam yang sebenarnya. Dengan demikian, solusi <em>worldview</em> Islam dalam Pendidikan Agama adalah pemahaman konsep-konsep kunci dalam <em>worldview</em> Islam dan internalisasi adab yang mencakup dalam segala hal, sesuai dengan ketetapan serta ketentuan yang tidak bertentangan dengan syari’at Islam.</p>
Suplementación de quitosano en la dieta de pollitas Rhode Island Red y su efecto en el comportamiento productivo y variables hematológicas
Authors: Peña-Torres Edgar Fernando , Ortega José Abel , Lizárraga-Velázquez Cynthia Esmeralda , Hernández Crisantema , León Cañedo Jesús Armando , Benitez-Hernández Asahel 
Published: July 2023

El quitosano es un polímero que se obtiene a partir de subproductos de crustáceos, el cual posee propiedades antioxidantes, antimicrobianas e inmunoestimulantes que pueden ser aprovechadas para la promoción del crecimiento en aves de corral sin alterar su estado de salud. El objetivo del estudio fue evaluar el efecto de la inclusión dietética de quitosano (0.55 % y 0.65 %) sobre el comportamiento productivo y los parámetros hematológicos en pollitas Rhode Island Red. Se utilizaron 45 pollitas con un peso promedio de 36 ± 7.8 g, las cuales fueron alojadas en jaulas de 1.0 m2 (5 animales/jaula). Las pollitas fueron alimentadas por 21 días con dietas con diferentes inclusiones de quitosano: 1) dieta testigo (tipo comercial), 2) dieta testigo + quitosano al 0.55 % (CH55), 3) dieta testigo + quitosano al 0.65 % (CH65). Al final del ensayo de alimentación, el crecimiento, el índice de conversión alimentaria (ICA), la biometría hemática y bioquímica sanguínea fueron analizados. La suplementación dietética con quitosano incrementó el peso final de las pollitas y hasta 27 % la ganancia diaria de peso (P<0.05), en comparación con el tratamiento testigo. El ICA no mostró cambios significativos con la suplementación de quitosano. La concentración de glucosa en sangre incrementó con la adición de quitosano a la dieta (P<0.05). Las variables de colesterol total, colesterol HDL, colesterol VLDL, triglicéridos, proteína total y la biometría hemática no mostraron cambios significativos (P>0.05). Se concluye que la adición de quitosano en ambas dosis favorece el crecimiento sin alterar el estado de salud de las pollitas.
PERKEMBANGAN FITRAH RELIGIUSITAS MANUSIA DALAM PERSPEKTIF PENDIDIKAN ISLAM
Authors: Amin Askur , Rinaldi Rahmad 
Published: July 2023

This study aims to understand how school principals can carry out their leadership according to procedures, and try to explain how school principals in carrying out their leadership are able to move teachers, students, and school residents to always improve the quality of education at MTs Al-Ulum Medan. Things that are observed by related researchers; 1) How is the implementation of the principal's leadership in carrying out its function to improve the quality of the school, 2) What is the role of the principal's leadership in dealing with obstacles in carrying out his duties. For this reason, researchers are interested in conducting research on "Leadership of Principals in Improving the Quality of Education at MTs Al-Ulum Medan.
Penerapan Problem Based Learning dalam Pendidikan Agama Islam
Authors: Suraiya Suraiya 
Published: July 2023

Educators should choose a learning model that can generate students’ enthusiasm for learning and develop their potential so that they are able to solve the problems faced in life. Problem Based Learning is one of learning models that is considered can maximize the students’ potential and guide them to have the ability to solve problems in life. Problem Based Learning (PBL) is based on constructivism and accommodates students' involvement in the learning process and problem solving. To apply PBL in the learning process, there are several principles and procedures that must be understood by educators. To implement PBL in the learning process, educators should follow the procedures or implementation stages. The procedure for implementing PBL is divided into several steps, namely: problem orientation, organizing students to study (in groups), investigation or data collection, developing and presenting work results and finally; evaluation and reflection. This PBL model certainly has advantages and disadvantages, so educators should study all things related to this PBL to maximize results and minimize deficiencies, educators should adhere to the principles and procedures for implementing them in the learning process because PBL is one of the learning models that is capable to answer the needs of students and be relevant to the demands of this century.
Memaksimalkan Kualitas Hidup dengan Komunikasi Terapeutik pada Lansia di Panti Jompo Tresna Werdha Natar, Lampung Selatan
Authors: Kartika Tina , Sarwoko  , Besar Ibrahim , Suharti Bangun , Noviera Fri Rejeki 
Published: July 2023

Pengabdian Kepada Masyarakat ini dilakukan di Panti Jompo Tresna Werdha Natar Lampung Selatan, dengan topik memaksimalkan kualitas hidup lansia dengan komunikasi terapeutik. Hal ini berguna bagi kehidupan lansia untuk mendukung kehidupan sehari-hari mereka yang jauh dari keluarga. Orang-orang yang ada di panti jompo ini dapat menggantikan keberadaan keluarga mereka. Untuk lebih mendekatkan diri satu sama lain baik para panti jompo maupun para karyawan memerlukan kesadaran dan teknik komunikasi terapeutik agar saling dan bersosialisasi. Komunikasi terapeutik berfungsi untuk menurunkan derajat kecamasan pada lansia. Tujuan pengabdian ini adalah untuk memaksimalkan teknik komunikasi terapeutik para pegawai dan para peserta, serta para lansia dan para lansia di panti jumpo Tresna Werdah. Peserta pengabdian terdiri dari 21 orang pegawai panti jumpo tersebut dan 80 orang lansia. Dengan metode ceramah, diskusi kelompok dan bernyanyi bersama dapat menurunkan derajat kecemasan para lansia. Dengan sosialisasi yang dilakukan maka didapatkan menambahan pemahaman para pegawai tentang teknik komunikasi terapeutik para pegawai di panti jompo Tresna Werdha Natar Lampung Selatan.
Pencapaian Kompetensi Dasar Materi Musik Kelas XI SMAN 4 Padang
Authors: El Hanif Muhammad Zaki , Handra Kadir Tulus 
Published: July 2023

This study aims to find out and describe the process of achieving the basic competencies of grade XI music materials at SMA N 4 Padang. The type of research used is qualitative research with descriptive methods of analysis. The main instrument in this study was the researchers themselves. Data collection techniques are conducted by means of observations, interviews, library studies and documentation. The steps of analyzing data are collecting data, describing data and concluding data. The results showed that the achievement of basic competencies of cultural arts subjects of music material class XI IS 1 as reflected in the implementation of the learning, has not been achieved as planned in the learning planning. The reason the researchers say is still not achieved, because in the implementation of learning by teachers focused on "the practice of playing songs instrumentally the song 'Ibu Kita Kartini' and the song 'Minangkabau' with pianika instruments, recorders, and guitar accompaniment. Teacher's mastery of materials also plays an important role in achieving learning objectives. The teacher of cultural arts at SMA N 4 Padang has dance skills, and is less so mastering music art material. This causes the implementation of cultural arts learning music material is not in accordance with the learning objectives set out in the learning planning.
Meningkatkan Motivasi Dan Hasil Belajar Siswa Dalam Pembelajaran Seni Tari Pada Masa Pandemi Covid-19 Di SMP N 4 Tarusan
Authors: Rahmayanti Dia , Astuti Fuji 
Published: July 2023

This type of research is Class Action Research (PTK). This research will be carried out 2 cycles, cycle I is done 2 times and cycle II is done 2 times. The intrument used in this study are motivational questionnaires and student knowledge tests. This type of data uses primary data and secondary data. Data collection techniques are carried out by means of observation (observation), tests of learning outcomes (tests for work) and tests of student motivation in cultural arts (dance) subjects, then completed with documentation. Data is analyzed using the percentage formula. The results showed that the use of Demonstration Methods and lectures in the learning of cultural arts, especially dance arts in class VIII.3 junior high school N 4 Tarusan, South Coast can increase learning outcomes In addition to the use of Demonstration Methods, Lecture Methods and media can also avoid saturation in students in following the teaching and learning process, so as to foster student motivation, and more fun learning. This is evidenced by the existence of student learning outcomes in class VIII.3 in cycle I of the average student learning outcome of 61.61, with quite good criteria. Furthermore, student motivation towards cultural arts (dance) subjects averaged 53 with unfavorable criteria. In cycle II student learning outcomes increased by an average of 84.51% of excellent criteria. Furthermore, the motivation of students against dance arts subjects averaged 69.00 with quite good criteria. It can be concluded that the selection of strategies using the Demonstration Method, lecture method and media has succeeded in achieving the target above KKM which is 75.
Koreografi Tari Zapin Bertasbih Pada Sanggar Tasik Malay Art Di Pekanbaru
Authors: Fernando Yose , Mansyur Herlinda 
Published: July 2023

This research aims to analyze Zapin Bertasbih Dance Choreography in Sanggar Tasik Malay Art Pekanbaru. This type of research is qualitative research with descriptive methods of analysis. The research instrument is the researchers own and is assisted by supporting instruments such as stationery and cameras. Primary data types and secondary data. Data collection techniques are carried out by employing library studies, observations, interviews and documentation. The steps to analyze the data are to describe, interpret and draw conclusions. The results showed that Zapin Bertasbih dance choreography performed by choreographer Tri Sisca Noviani is a new dance creation worked with a choreographic approach. Zapin Bertasbih Dance Choreography can be seen in Form and Content. In the form motion, there are 15 kinds of motion, floor patterns in the form of vertical, horizontal, diagonal and zigzag, the composition of groups in the form of simultaneous and split, dancers (6 people), wearing Malay costumes, dance accompaniment by wearing gambus, accordion, flute, darbuka, marwas and tambur, property using tasbih. In content, among them the idea that arises from taking things done by Muslims in performing worship practices to the creator by using tasbih as his property. The atmosphere that appears in Zapin Dance is peaceful, joyful and calm. Therefore, Zapin Bertasbih Dance is worked on with choreographic planning by his stylist. Because Zapin Bertasbih Dance begins with an idea that departs from Zapin Melayu itself where Zapin Melayu underlies the creation of Zapin Bertasbih. The source of Garapan from Zapin Bertasbih is some movements from Zapin Melayu, namely the movement of worship, Middle Dizziness, Broken Chicks and the Movement of Meniti batang. Then worked by the stylist and arranged movements that have been created into a new form of dance. In content, among them the idea that arises from taking things done by Muslims in performing worship practices to the creator by using tasbih as his property.