bluuebunny/crossref_metadata_2025_split huggingface dataset:
Post-traumatic Implant Surgical Rehabilitation of the Alveolar Ridge of the upper Jaw
Authors: Bizevski Danco , Jakupi - Alimani Jetmire , Isak Martini , Bajramov Enes 
Published: January 2023

Introduction; Dental trauma can be defined as an injuryto the oral region including the lips, teeth, periodontal tissues, tongue and/or alveolar processes.
The aims of management will depend on the age of the patient, type of tooth (primary or permanent) and the extent of the injuries. The treatment varies from preserving the tooth,extraction of the tooth and immediate implant placement. Immediate implantation is defined as placement of the implant into alveolus of the extracted teeth immediately after extraction.
Materials and methods; A 45-year-old patient, suffered teethand dental bridge fracture and injury during car accident.Immediate teeth extraction was performed and immediate implantation with bone ridge preservation was performed, to rehabilitate the lost teeth. Patient underwent successfully for prosthetic rehabilitation 8 months after these procedures.
Conclusion; Affected traumatized teeth often have areduced prognosis and, in some instances, may requireextraction. The majority of dental trauma is initially seenwithin a primary rather than secondary care setting. General dental practitioners should therefore be able to effectively manage the most common dental injuries, and to referthe complicated ones to oral surgeon. Dental implants are reliable to replace teeth lost because of traumatic dental injury. The timing of implant placement may be immediate,early, conventional, or late and is determined by the extent of the trauma, remaining growth, and conditions of the hardand soft tissues.
Surgical Treatment of uncomplicated Pilonidal Sinus with the simple Closed Technique.
Authors: Bollano Enton , Lilaj Krenar , Thereska Dariel 
Published: January 2023

Introduction; The pilonidal sinus represents a benign cystic formation located between the skin and the coccygeal bone in the mediogluteal line. It was first described in 1833 by Herbert Mayo and R.M Hodges.
It is thought that the cause is the penetration of hair into the subcutaneous intergluteal area. This pathology is the result of an inflammatory expansion of the hair follicle accompanied by the expansion of the fatty glands and sweat.
The purpose of the study: To evaluate our results in the treatment of this pathology with the technique above and to compare them with the results of similar works referred to in the world literature.
Materials and Method; In our study are recorded 60 patients, diagnosed with uncomplicated and previously unoperated sacrococcygeal fistula were included in the study. Divided by sex, 43 men and 17 women. The average age of our patients was 29.5 years (18-41 years). The time period of the study extends from January 2015 - March 2019…
Results; All patients suffered from the chronic phase of pilonidal disease. The intervention was carried out with the help of spinal anesthesia by injecting 2 ml of 2% sol lidocaine in the L 3-L4 space. During the intervention, two grams of intravenous cephalosporin are applied. Interventions are performed by placing the patient in a ventral position with leucoplasts gluteal diversion.
Conclusion; The presence of hair inside the pilonidal sinus is a reason in favor of the acquired theory regarding the pathogenesis. In our study, only one patient referred to heredity related to pathology. The duration of the intervention depends on the skills of the surgeon and the difficulty of the pathology. The hospitalization was determined by postoperative complications.
PENGARUH TAX AVOIDANCE, PROFITABILITAS DAN LAVERAGE TERHADAP NILAI PERUSAHAAN PROPERTI DAN REAL ESTATE DI BURSA EFEK INDONESIA
Authors: Putri Meyna Ananda , Taufiq Eindye 
Published: January 2023

Abstrak
Penelitian bertujuan untuk mengetahui pengaruh tax avoidance, profitabilitas dan leverage terhadap nilai perusahaan. Populasi yang digunakan pada penelitian ini yaitu seluruh perusahaan sektor properti dan real estate yang tercatat di Bursa Efek Indonesia. Hasil penelitian menunjukan bahwa terdapat pengaruh negatif namun tidak signifikan antara tax avoidance terhadap nilai perusahaan. Sementara itu profitabilitas dan leverage menunjukan pengaruh positif signifikan terhadap nilai perusahaan. Hasil penelitian menyarankan agar para investor memperhatikan tingkat tax avoidance, profitabilitas dan leverage dalam perusahaan untuk dapat membantu memilih perusahaan yang tepat dalam berinvestasi.
Kata kunci : tax avoidance, profitabilitas, leverage dan nilai perusahaan
Abstract
This study aims to determine the effect of tax avoidance, profitability, and leverage on firm value. The population used in this study is all property and real estate sector companies listed on the Indonesia Stock Exchange. The results showed that there was a significant but insignificant effect of tax avoidance on firm value. Meanwhile, profitability and leverage showed a significant positive effect on firm value. The results of the study suggest that investors pay attention to the level of tax avoidance, profitability, and leverage in a company to be able to help choose the right company to invest in.
Keyword : tax avoidance, profitability, leverage and firm value
PENGARUH KONSENTRASI PACLOBUTRAZOL DAN DOSIS PUPUK NPK TERHADAP PERTUMBUHAN DAN HASIL TANAMAN TOMAT (Lycopersicon esculentum)
Authors: Sugiharto Nella Oktavianty , Sulistyono Agus , Kusumaningrum Nora Augustien 
Published: January 2023

Tomat merupakan jenis komoditi hortikultura yang cukup banyak diminati oleh masyarakat Indonesia karena kandungan gizi yang cukup tinggi. Penelitian ini bertujuan untuk mengetahui pengaruh konsentrasi paclobutrazol dan dosis pupuk NPK terhadap pertumbuhan dan hasil tanaman tomat. Penelitian ini dilaksanakan di kebun percobaan Fakultas Pertanian Universitas Pembangunan Nasional “Veteran” Jawa Timur pada bulan Desember 2020 – April 2021 dengan menggunakan polybag. Penelitian ini merupakan percobaan faktorial yang disusun berdasarkan Rancangan Acak Kelompok (RAK) terdiri dari dua faktor, faktor pertama yaitu konsentrasi paclobutrazol (P) terdiri dari: P0 = 0 ppm (kontrol), P1 = 150 ppm, P2 = 300 ppm, P3 = 450 ppm dan faktor kedua dosis pupuk NPK terdiri dari: N0 = 25 g/tanaman (kontrol), N1 = 12,5 g/tanaman, N2 = 20 g/tanaman, N3 = 27,5 g/tanaman. Hasil penelitian menunjukkan kombinasi 150 ppm paclobutrazol + 27,5 g/tanaman pupuk NPK meningkatkan jumlah bunga, jumlah buah total per tanaman, bobot buah total per tanaman, fruitset, dan kandungan Vitamin C.
PERBANYAKAN SPORA ENDOMIKORIZA INDIGENUS PADA PERKEBUNAN KAKAO DENGAN PEMBERIAN MEDIA TANAM DAN KADAR AIR TANAH BERBEDA
Authors: Trisnayanti Ni Kadek , Rai I Nyoman , Wiraatmaja I Wayan 
Published: January 2023

Kakao merupakan tanaman perkebunan yang berpotensi untuk meningkatkan pendapatan negara. Di Bali, produksi kakao tertinggi adalah di Kabupaten Jembrana. Peningkatan produktivitas tanaman kakao dapat dilakukan dengan cara pemupukan ramah lingkungan menggunakan pupuk hayati Fungi Mikoriza Arbuskula (FMA). Tujuan penelitian ini adalah untuk mendapatkan isolat FMA indigenus dan perbanyakannya dengan media tanam berbeda dan kadar air tanah. Penelitian dilakukan pada bulan Juli 2020 sampai Januari 2021. Sampel FMA untuk isolasi dan identifikasi diambil dari Desa Pulukan, Kecamatan Pekutatan, Kabupaten Jembrana, sedangkan isolasi dan identifikasi FMA dilakukan di Laboratorium Agronomi dan Hortikultura Fakultas Pertanian Unud, Laboratorium Penyakit Tanaman, Laboratorium Sumber daya Genetik dan Biologi Molekuler Unud dan Rumah Kaca Kebun Percobaan Fakultas Pertanian Unud, Denpasar. Perbanyakan spora FMA menggunakan Rancangan Acak Lengkap (RAL) dengan 2 faktor dan 4 ulangan. Faktor pertama adalah media tanam, terdiri atas empat taraf perlakuan, yaitu media tanam tanah, tanah dan pasir, tanah dan kompos, dan tanah, pasir dan kompos, sedangkan faktor kedua adalah kadar air tanah yang terdiri atas tiga taraf perlakuan, yaitu kadar air tanah 100%, 70%, dan 40% kapasitas lapang. Hasil isolasi dan identifikasi menunjukkan terdapat tiga genus spora FMA yang ditemukan yaitu Glomus, Gigaspora, Acaulospora. Hasil perbanyakan spora menunjukkan media tanam tanah dan pasir dengan kombinasi kadar air tanah 40% kapasitas lapang menghasilkan spora paling tinggi yaitu rata-rata 62 spora.
Perncangan Aplikasi Ujian Sertifikasi MTA Berbasis Web
Authors: Abdillah Rasyid Muhammad Fauzan , Satra Ramdan , Herman Herman 
Published: January 2023

Saat ini Fakultas Ilmu Komputer Universitas Muslim Indonesia tengah mengadakan ujian sertifikasi kompetensi keahlian yang bekerja sama dengan Microsoft. Dengan adanya kerjasama tersebut maka mahasiswa dapat mendapatkan sertifikat keahlian dengan mengikuti ujian sertifikasi. Namun saat ini ujian sertifikasi MTA masih berbayar sehingga mahasiswa kesulitan untuk melakukan latih uji soal dengan ujian sertifikasi dari Microsoft tersebut. Berangkat dari permasahan tersebut maka tujuan dari penelitian ini yaitu adanya sebuah perangkat lunak sebagai wadah simulasi ujian sertifikasi dengan membuat aplikasi simulasi ujian sertifikasi MTA berbasis web guna untuk membantu mahasiswa dalam persiapan ujian sertifikasi. Dalam melakukan penelitian ini, jenis penelitian yang digunakan yaitu menggunakan metode Waterfall dan bentuk pengujiaannya menggunakan metode Blackbox Testing. Hasil dari penelitian ini yaitu adanya sebuah aplikasi ujian simulasi sertifikasi MTA berbasis web yang dapat digunakan mahasiswa sebagai latihan ujian simulasi MTA dengan jenis soal yang hampir sama. Kesimpulan dari penelitian ini adalah dapat memudahkan mahasiswa untuk melakukan persiapan dalam ujian sertifikasi
Analisis Perbandingan Tools Forensik Digital Pada Instagram Messenger Menggunakan Metode Nasional Institute of Standards and Technology
Authors: Supardin Harno , Satra Ramdan , Asis Muhammad Arfah 
Published: January 2023

Perkembangan teknologi dari waktu ke waktu sangat pesat, salah satunya adalah perkembangan smartphone yang selalu berkembang dari segi sistem operasi, fitur, spesifikasi, dan aplikasi. Teknologi yang semakin canggih saat ini telah menjadi bagian penting dari kehidupan masyarakat, beberapa aktivitas kehidupan masyarakat dapat dilakukan dengan memanfaatkan teknologi termasuk melakukan tindakan kejahatan di dunia maya. Salah satu aplikasi media sosial yang banyak digunakan adalah Instagram. Instagram messenger menyebabkan cybercrime, pornografi, penipuan, dan cyberbullying. Penelitian ini bertujuan untuk membandingkan kinerja tools forensik digital dalam mendapatkan bukti digital pada Instagram messenger dengan mengunakan metode NIST. Hasil penelitian ini menunjukan bahwa MOBILedit Forensic dan Magnet Axiom memiliki hasil akurasi berikut dalam mengembalikan data yang telah terhapus pada Instagram messenger, MOBILedit Forensic 69,23% dan Magnet Axiom 76,92%.
ANALISIS PENAMBAHAN JURUSAN GARDU DISTRIBUSI I.598 PADA PENYULANG APEL PT.PLN RAYON RIVAI PALEMBANG
Authors: Marniati Yessi - 
Published: January 2023

The final report discusses replenishment plan of distribution substation I.598 major at apel feeder in PT. PLN Rival Rayon Palembang to decreases overload fault, drop voltage, and power losses conductor. According to the discussion on the final report, obtained replenishment plan of distribution substation major is able to decreases one of major’s loading which has the biggest load, namely B major from 65,61% is decreased to 21,95%, decreases drop voltage of B major’s conductors from 7,5% is decreased to 1% on phase R, 4,3% is decreased to 1,4% on phase S and 6% is decreased to 1,9% on phase T and also decreases power losses of B major’s conductors from 1,6 kW is decreased to 0,04 kW on phase R, 0,6 kW on decreased to 0,09 kW on phase S and 1,2 kW is decreased to 0,19 kW on phase T. These conditions are occurred by replenishment of conductor and dividing B major’s load to new majors, namely C and D major so that they influence loading, current load, and conductor length will be decreased. Therefore overload fault, drop voltage, and power losses conductor will be minimized.
Key words : Replenishment of Substation Major, Overload, Drop Voltage, Power Losses
PENERAPAN HAZARD ANALYSIS AND CRITICAL CONTROL POINT (HACCP) PADA PROSES PRODUKSI DI UMKM PEMPEK (Studi Kasus : Pempek Cek Mardia)
Authors: Agung Pramana Muhammad , Desi Kusmindari Christofora , Laili Reni 
Published: January 2023

Abstrak
Penelitian ini bertujuan untuk mengetahui penerapan Hazard Analysis And Critical Control Point (HACCP) Pada Proses Produksi di UMKM Pempek X. Berdasarkan hasil dan pembahasan dapat ditarik kesimpulan yaitu rata-rata keseluruhan kesenjangan penerapan HACCP sebesar 15,54%, artinya penerapan sistem HACCP dijalankan dan didokumentasikan hampir secara keseluruhan memenuhi panduan HACCP, namun terdapat sedikit kelalaian dalam penerapannya. Kesenjangan tertinggi terdapat pada variabel pelaksanaan persyaratan dasar meliputi SSOP dengan nilai rata-rata kesenjangan sebesar 26,75% Kesenjangan pada variabel lain yaitu tim HACCP sebesar 28%, Variabel deskripsi produk nilai 40%, analisa bahaya sebesar 15,38%, penyusunan dan verifikasi bagan alir sebesar memiliki nilai yang terkecil 5%, prosedur verifikasi sistem HACCP sebesar 2,8%. Rata-rata keseluruhan penyimpangan SSOP sebesar 26,75%. Terdapat 6 indikator dalam penerapan SSOP, dimana nilai penyimpangan tertinggi ada 2 indikator yaitu kebersihan permukaan yang kontak langsung dengan makanan dan Pemberantasan hama memiliki nilai penyimpangan sama sebesar 26,66%, Nilai penyimpangan pada indikator SSOP lainnya yaitu keamanan air memiliki nilai yang terkecil sebesar 24%, pencegahan kontaminasi silang sebesar 22,22%, fasilitas sanitasi cuci tangan dan toilet sebesar 36% pengendalian kesehatan karyawan nilai sebesar 25%. Berdasarkan hasil evaluasi fantor penyebab bahaya pada produksi pempek Cek Mardia yaitu saat pengoreng pempek yang di mana minyak saat pengoreng pempek terkena tangan, adanya tindakan perbaikan yaitu memakai sarung tangan anti panas dan Saat pembersihan alat produksi yang di mana tempat pemberishan alat produksi terdapat ada lumut di lantai dimana tempat pembersihan di luar ruangan, memerlukan adanya tindakan perbaikan yaitu memakai boots karet dan tempat pembersihan alat di pindahkan di dalam ruangan.

Kata kunci: HACCP, UMKM
Insulin-like peptide 8 (Ilp8) regulates female fecundity in flies
Authors: Li Haomiao , Luo Xi , Li Na , Liu Tao , Zhang Junzheng 
Published: January 2023

Introduction: Insulin-like peptides (Ilps) play crucial roles in nearly all life stages of insects. Ilp8 is involved in developmental stability, stress resistance and female fecundity in several insect species, but the underlying mechanisms are not fully understood. Here we report the functional characterization of Ilp8s in three fly species, including Bactrocera dorsalis, Drosophila mercatorum and Drosophila melanogaster.Methods: Phylogenetic analyses were performed to identify and characterize insect Ilp8s. The amino acid sequences of fly Ilp8s were aligned and the three-dimensional structures of fly Ilp8s were constructed and compared. The tissue specific expression pattern of fly Ilp8s were examined by qRT-PCR. In Bactrocera dorsalis and Drosophila mercatorum, dsRNAs were injected into virgin females to inhibit the expression of Ilp8 and the impacts on female fecundity were examined. In Drosophila melanogaster, the female fecundity of Ilp8 loss-of-function mutant was compared with wild type control flies. The mutant fruit fly strain was also used for sexual behavioral analysis and transcriptomic analysis.Results: Orthologs of Ilp8s are found in major groups of insects except for the lepidopterans and coleopterans, and Ilp8s are found to be well separated from other Ilps in three fly species. The key motif and the predicted three-dimensional structure of fly Ilp8s are well conserved. Ilp8 are specifically expressed in the ovary and are essential for female fecundity in three fly species. Behavior analysis demonstrates that Ilp8 mutation impairs female sexual attractiveness in fruit fly, which results in decreased mating success and is likely the cause of fecundity reduction. Further transcriptomic analysis indicates that Ilp8 might influence metabolism, immune activity, oocyte development as well as hormone homeostasis to collectively regulate female fecundity in the fruit fly.Discussion: Our findings support a universal role of insect Ilp8 in female fecundity, and also provide novel clues for understanding the modes of action of Ilp8.
CFD supported scale up of perfusion bioreactors in biopharma
Authors: Kuschel Maike , Wutz Johannes , Salli Mustafa , Monteil Dominique , Wucherpfennig Thomas 
Published: January 2023

The robust scale up of perfusion systems requires comparable conditions over all scales to ensure equivalent cell culture performance. As cells in continuous processes circulate outside the bioreactor, performance losses may arise if jet flow and stirring cause a direct connection between perfusion feed and return. Computational fluid dynamics can be used to identify such short circuit flows, assess mixing efficiencies, and eventually adapt the perfusion setup. This study investigates the scale up from a 2 L glass bioreactor to 100 L and 500 L disposable pilot scale systems. Highly resolved Lattice Boltzmann Large Eddy simulations were performed in single phase and mixing efficiencies (Emix) furthermore experimentally validated in the 2 L system. This evaluation gives insight into the flow pattern, the mixing behavior and information on cell residence time inside the bioreactors. No geometric adaptations in the pilot scale systems were necessary as Emix was greater than 90% for all conditions tested. Two different setups were evaluated in 2 L scale where the direction of flow was changed, yielding a difference in mixing efficiency of 10%. Nevertheless, since Emix was confirmed to be &gt;90% also for both 2 L setups and the determined mixing times were in a similar range for all scales, the 2 L system was deemed to be a suitable scale down model. The results demonstrate how computational fluid dynamic models can be used for rational process design of intensified production processes in the biopharmaceutical industry.
Modifying effect of the serum level of brain-derived neurotrophic factor (BDNF) on the association between BDNF methylation and long-term cardiovascular outcomes in patients with acute coronary syndrome
Authors: Choi Wonsuk , Kang Hee-Ju , Kim Ju-Wan , Kim Hee Kyung , Kang Ho-Cheol , Kim Sung-Wan , Kim Jung-Chul , Ahn Youngkeun , Jeong Myung Ho , Kim Jae-Min 
Published: January 2023

IntroductionThis study investigated the potential modifying effects of the serum brain-derived neurotrophic factor (sBDNF) level on the association between BDNF methylation status and long-term cardiovascular outcomes in acute coronary syndrome (ACS) patients.MethodsFrom 2006 to 2012, hospitalized ACS patients were consecutively recruited. The sBDNF level and BDNF methylation status were assessed at baseline in 969 patients who were followed up for major adverse cardiac events (MACEs) over 5–12 years, until 2017 or death. Cox proportional hazards models were utilized to compare the time to first composite or individual MACEs between individuals with lower and those with higher average BDNF methylation levels in the low and high sBDNF groups, respectively. The modifying effects of the sBDNF and average BDNF methylation levels on first composite and individual MACEs were analyzed using Cox proportional hazards models after adjusting for potential covariates.ResultsIn the low sBDNF group, a higher average BDNF methylation level was linked to an increase in composite MACEs independent of confounding variables, but not in the high sBDNF group [HR (95 percent CI) = 1.04 (0.76–1.44)]. The interaction effect between the sBDNF and average BDNF methylation levels on composite MACEs was significant after adjusting for covariates (P = 0.008).ConclusionCombining the BDNF methylation status and sBDNF levels may help identify ACS patients who are likely to have unfavorable clinical outcomes.
Energy metabolism disorder dictates chronic hypoxia damage in heart defect with tetralogy of fallot
Authors: Liu Libao , Huang Lei , Yao Lishuai , Zou Fan , He Jinyuan , Zhao Xiaodong , Mei Lugang , Huang Shuai 
Published: January 2023

BackgroundTetralogy of Fallot (TOF) belongs to cyanotic heart damage, which is the most common in clinic. In the chronic myocardial hypoxia injury related to TOF, the potential molecular mechanism of cardiac energy metabolism remains unclear.Materials and methodsIn our study, microarray transcriptome analysis and metabonomics methods were used to explore the energy metabolism pathway during chronic hypoxia injury. The gene expression omnibus (GEO) dataset GSE132176 was obtained for analyzing the metabolic pathways. The clinical samples (right atrial tissues) of atrial septal defect (ASD) and TOF were analyzed by metabonomics. Next, we screened important pathways and important differential metabolites related to energy metabolism to explore the pathogenesis of TOF.ResultsGene set enrichment analysis (GSEA) indicated that fructose 6-phosphate metabolic process, triglyceride metabolic process, and et al. were significantly enriched. Gene set variation analysis (GSVA) results showed that significant difference of ASD group and TOF group existed in terpenoid metabolic process and positive regulation of triglyceride metabolic process. Pathways with significant enrichment (impact &gt; 0.1) in TOF were caffeine metabolism (impact = 0.69), sphingolipid metabolism (impact = 0.46), glycerophospholipid metabolism (impact = 0.26), tryptophan metabolism (impact = 0.24), galactose metabolism (impact = 0.11). Pathways with significant enrichment (impact &gt; 0.1) in ASD are caffeine metabolism (impact = 0.69), riboflavin metabolism (impact = 0.5), alanine, aspartate and glutamate metabolism (impact = 0.35), histidine metabolism (impact = 0.34) and et al.ConclusionDisturbed energy metabolism occurs in patients with TOF or ASD, and further investigation was needed to further clarify mechanism.