bluuebunny/crossref_metadata_2025_split huggingface dataset:
Constraints in Dental Services Utilization Among the Dental Hospital of Jodhpur Region in Rajasthan, India
Authors: Chauhan Minal , Chand Sachin , Khan Mohsin , Shaktawat Neha , Ali Shadab , Kavitake Ranjeet D. 
Published: January 2025

Abstract

Background:
There has been a lot of interest in understanding oral health care utilization behavior as it is important for the delivery of effective oral health care. Identifying the barriers to dental services is one of the basic steps to improving the public health.

Aim:
We aimed to determine the barriers affecting the utilization of dental services in dental institutes.

Materials and Methods:
A cross-sectional survey was conducted among the patients attending the outpatient department of dental institute during the year 2023 among the 364 subjects and the data were collected using a specially designed and pretested questionnaire. The data were analyzed by descriptive and inferential statistics with the help of Statistical Package for Social Sciences version 22.0.

Results:
It was seen that the majority of the participants agreed that cost (55%) was identified as the most imperative factor affecting dental services followed by the dentist-patient relationship at a statistically significant level (P = 0.0001).

Conclusion:
The foremost barriers to dental care utilization were cost, fear, and organization. However, the policies should be fair and impartial as policymakers, administrators, and insurance organizations play a key role in the health care system.
Analyzing the Effects of HPV Vaccination Programs on the Incidence of Oral Cancers and Other Related Pathologies
Authors: Singh Jyotsna , Shivam Animesh Kr 
Published: January 2025

Abstract

Objective:
To investigate the impact of human papillomavirus (HPV) vaccination programs on the incidence of oral cancers and other related pathologies.

Materials and Methods:
A cross-sectional study was conducted with a sample size of 500 participants aged 18–35 years, recruited from urban and rural healthcare centers. Data were collected through questionnaires and medical records, analyzing the incidence of oral cancers and other pathologies in vaccinated versus nonvaccinated individuals. Statistical analysis was performed using chi-square tests and logistic regression models.

Results:
The study found a significant reduction in the incidence of oral cancers and other related pathologies among vaccinated individuals compared with nonvaccinated individuals (P < 0.05). Specifically, the incidence of HPV-positive oropharyngeal cancers was notably lower in the vaccinated group than in the nonvaccinated group. Logistic regression analysis confirmed that vaccination was a significant protective factor against developing oral cancers (odds ratio = 0.45, 95% confidence interval = 0.30–0.68).

Conclusion:
HPV vaccination programs are associated with a significant reduction in the incidence of oral cancers and related pathologies. These findings support the continued promotion and expansion of HPV vaccination programs as a public health strategy to prevent oral cancers.
Identification of patients with advanced pancreatic cancer who might benefit from third-line chemotherapy
Authors: Kim Bomi , Kim Jaihwan , Yang Soomin , Ahn Jinwoo , Jung Kwangrok , Lee Jong-Chan , Hwang Jin-Hyeok 
Published: January 2025

BACKGROUND
Survival rates of patients with advanced pancreatic cancer (APC) have been improved with palliative chemotherapy series. The current preferred first-line regimen consists of combination therapy of 5-fluorouracil (5-FU)/leucovorin (LV), irinotecan, and oxaliplatin (FOLFIRINOX) or gemcitabine plus albumin-bound paclitaxel (GNP). After failure of first-line chemotherapy, there are a few options for subsequent therapy including switch to the unused first-line regimen or nano-liposomal irinotecan and 5-FU/LV. However, there are limited studies on the efficacy of third-line chemotherapy after failure of second-line chemotherapy.
AIM
To identify patients with APC who might benefit from third-line chemotherapy.
METHODS
Medical records from a single tertiary hospital were retrospectively reviewed between 2012 and 2021. The study included patients with histologically or cytologically confirmed metastatic or locally APC who underwent first-line FOLFIRINOX or GNP and subsequently received third-line chemotherapy. Overall survival (OS) after diagnosis and OS after third-line chemotherapy (OS3) were defined as the interval from the diagnosis to all-cause death and the time between the initiation of the third-line chemotherapy to all-cause death, respectively.
RESULTS
A total of 141 patients were enrolled. The median patient age at diagnosis was 61.8 years (36.0-86.0), and 54.9% were male. The first-line regimen was FOLFIRINOX (67.4%) or GNP (32.6%). The second-line regimen was FOLFIRINOX (27.0%), GNP (52.5%), or other (20.6%). The median OS was 19.0 months, and the median OS3 and progression-free survival after third-line treatment were 15.3 and 7.3 weeks, respectively. With regard to the best tumor response during third-line chemotherapy, 1.4% had partial response, 24.8% had stable disease, and 59.6% had progressive disease. The following clinical factors before third-line chemotherapy affected OS3: Good performance status (PS), serum carbohydrate antigen 19-9 (CA19-9) level < 1000 U/mL, duration of second-line chemotherapy ≥ 19 weeks, and no peritoneal seeding.
CONCLUSION
This study identified that patients with good PS, CA19-9 < 1000 U/mL, second-line chemotherapy ≥ 19 weeks, and no peritoneal seeding before starting third-line treatment may benefit more from third-line chemotherapy.
Prognostic value of inflammatory markers in predicting recurrence-free survival in gastrointestinal stromal tumor patients: A nomogram-based approach
Authors: Zhao Jin-Long , Wang Mao-Ying , Lv Yan-Zhi , Zhou Ye-Jiang 
Published: January 2025

BACKGROUND
There are currently no relevant studies at home or abroad that combine inflammatory indicators and nomograms to predict the prognosis of gastrointestinal stromal tumor (GIST) patients after surgery. The purpose of this study was to investigate the predictive value of related inflammatory indicators [systemic immune-inflammation index (SII), neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR) and monocyte/Lymphocyte ratio (MLR)] in patients undergoing GIST surgery, incorporating relevant risk factors to establish a nomogram prediction model, with the aim of better predicting the prognosis of GIST patients.
AIM
To explore the relationships between the SII, NLR, PLR, and MLR and postoperative recurrence in patients with GIST.
METHODS
This study retrospectively included patients who underwent GIST surgery from January 2014 to January 2017 and analyzed the potential relationships between the preoperative SII, NLR, PLR, and MLR and clinicopathological features. The independent risk factors influencing the prognosis of GIST patients were obtained via multivariate regression analysis, and a nomogram model based on the independent risk factors was established.
RESULTS
Among the 124 GIST patients included in the present study, 31 (25%) experienced recurrence within 5 years. Kaplan-Meier survival analysis revealed a correlation between the MLR and PLR and tumor size (P = 0.016 and P = 0.002, respectively). The preoperative SII, MLR, NLR, and PLR were significantly associated with recurrence-free survival (RFS) (P < 0.05). The multivariate analysis results identified the PLR, MLR, and targeted therapy as independent prognostic factors for patient outcomes.
CONCLUSION
Preoperative MLR and PLR, which are independent risk factors for GIST recurrence, were correlated with RFS. Nomograms based on the PLR, MLR and targeted therapy can be used for clinical treatment.
Pancreatic primitive neuroectodermal tumors: Clinical features, treatment, and influencing factors
Authors: He Yan-Fei , Wang Huan-Zhi , Hu Xiao-Dong , Liu Jun-Qiang , Li Hu-Ming , Wang Jie , Lu Shuang-Feng 
Published: January 2025

BACKGROUND
Data on clinical characteristics, treatment outcomes, and prognosis of pancreatic primitive neuroectodermal tumors (PNETs) are limited.
AIM
To analyze the clinical data of 30 patients with pancreatic PNETs to identify their clinical characteristics and factors associated with prognosis.
METHODS
We used the keywords "primary neuroectodermal tumor," "digestive tract," "pancreas," "pancreatic," and "gastrointestinal," individually or in combination, to collect data from a global database for all patients with pancreatic PNET to date. Univariate and Cox regression analyses were performed to identify prognostic factors for patient survival.
RESULTS
A total of 30 cases of pancreatic PNET were included in this study: 15 males and 15 females with a mean age of 24 years. The main symptom was abdominal pain (73.3%), and the median tumor size was 7.85 cm. Twenty-four patients (80.0%) underwent surgery and nineteen patients received adjuvant therapy. Local metastasis was observed in 13 patients (43.3%), lymph node metastasis in 10 patients (33.3%), and distant metastasis in 6 patients (20.0%). Local recurrence was observed in 13 patients (43.3%). The median survival time of all patients was 29.4 months, and the overall estimated 1-year and 3-year survival rates were approximately 66.0% and 36.4%, respectively. Univariate analysis showed that chemotherapy (P = 0.036), local metastasis (P = 0.041), lymph node metastasis (P = 0.003), distant metastasis (P = 0.049), and surgical margins (P = 0.048) were the prognostic factors affecting survival. Multivariate analysis revealed only lymph node metastasis (P = 0.012) as a prognostic factor.
CONCLUSION
Pancreatic PNET is extremely rare, occurs in young adults, has no apparent sex predisposition, has a high rate of metastasis and early recurrence, and has a very poor prognosis. The diagnosis of pancreatic PNET requires a combination of clinical symptoms, pathologic features, immunohistochemistry, and cytogenetic analysis. Univariate analysis suggested that chemotherapy, metastasis, and surgical margins were prognostic factors affecting survival, and multivariate analysis suggested that lymph node metastasis is an important prognostic factor. Therefore, early diagnosis, early and extensive resection, and adjuvant chemoradiotherapy may help improve prognosis.
Metastatic lymph node distribution and pathology correlations in upper and lower gastric cancer patients: A multicenter retrospective study
Authors: Yuan Xian-Bei , Sun Gang , Niu Jun , Dong Lei , Sui Yi , Lv Yong-Zhu 
Published: January 2025

BACKGROUND
Gastric cancer (GC) poses a significant threat to public health. However, the clinicopathological features and tumor biological behaviors vary among the GC patients, leading to individual variations in lymph node metastasis. Consequently, the stratification of lymph node dissection according to the specific type, particularly upper GC, has emerged as a prominent area of research.
AIM
To investigate the distribution of metastatic lymph nodes in patients with upper and lower GC and to analyze the differences in related pathological elements and prognosis.
METHODS
Differential analysis between upper and lower GC patients with various clinicopathological factors was performed using the chi-square test and rank-sum test. Logistic regression models were used to identify risk factors for GC lymph node metastasis, while Cox regression models were used to analyze risk factors affecting patient prognosis. The Kaplan-Meier method was used to construct survival curves associated with prognostic risk factors for GC.
RESULTS
Significant differences were observed between the two GC populations regarding tumor diameter, histological grade, pT stage, pN stage, tumor-node-metastasis (pTNM) stage, vascular invasion, and adjuvant chemotherapy usage (all P < 0.05). Lymph node metastasis rates were highest for Siewert type II patients in groups Nos. 1, 3, 2 and 7; for Siewert type III patients in groups Nos. 3, 1, 2 and 7; and for other/unclassified patients in groups Nos. 1, 3, 7, 2. In the lower GC samples, the sequences were Nos. 3, 6, 7, 4. Pathological type, pT stage, pTNM stage, and positive vascular invasion were independent risk factors for development of lymph node metastasis. Age, pathological type, pT stage, pN stage, pTNM stage, vascular invasion, and absence of adjuvant chemotherapy were identified as independent prognostic factors.
CONCLUSION
Upper GC showed a significantly higher malignancy grade and different lymph node metastasis pattern than lower GC.
ADMINISTRATIVE AND FINANCIAL CORRUPTION IN LIBYA: CAUSES AND COUNTERMEASURES
Authors: Lazrg Abduladem 
Published: January 2025

This paper seeks to shed light on the causes of administrative and financial corruption in Libya and to study the political, economic and social dimensions behind it. This paper starts with its approach to these factors that cause the spread of the phenomenon of corruption and its penetration into most state institutions and the exacerbation of its outcomes that have affected all aspects of life and led to huge material losses and the deterioration of services in general. Based on the pioneering role of scientific research in providing studies, recommendations and advice, this study presents the best ways to combat administrative and financial corruption in Libya and how to reduce it and then eliminate it. The study concludes that administrative and financial corruption is the main factor in the aggravation of political, economic, and social conditions and in feeding manifestations of instability, poverty, backwardness, injustice, and feelings of discontent towards the authorities. The study also concluded that corruption could be reduced by developing control tools, such as strengthening control laws, tightening penalties, cooperation between government authorities, advanced solutions, accountability and transparency, encouraging the reporting of corruption, and supporting research institutions to study this phenomenon, in addition to the role of religious institutions in condemning and prohibiting corruption.<p> </p><p><strong> Article visualizations:</strong></p><p><img src="/-counters-/soc/0729/a.php" alt="Hit counter" /></p>
Sustainable Business Models in Agritourism: an Opportunity For Achieving SDGS and Circular Economy
Authors: Dionizi Brikene , Kercini Donika 
Published: January 2025

Introduction: Agritourism, combining agricultural with tourism, presents a unique opportunity for sustainable development. The business with its sustainable practices can raise awareness and impact the customer behaviour.

Objective: This study explores sustanable business models (SBMs) in agritourism, focusing on their alignment with circular economy and sustanable development goals (SDGs), particularly SDG 12, which focuses on responsible consumption and production.

Theoretical Framework: Main concepts and theories support the importance of the system and how things are connected speaking about sustainability, providing a solid basis for supporting the investigation.

Method: Analizing two case studies in the country (Albania), the agritourism “Mrizi i Zanave” (Mrizi) and the village Thethi, the research highlights the agritourism’s role in fostering local economic growth, conserving cultural heritage, and promoting community resilience.

Results and discussions: By promoting resource efficiency, reducing waste, and enhancing local engagement, agritourism embodies SDG 12’s call for sustainability in production processes and consumption patterns. Key challenges, including infrastructure, are evaluated alongside opportunities such as fiscal incentives and the integration of local food systems. Findings emphasize the importance of tailored strategies, community engagement, and policy support to balance increasing tourist demands with environmental and cultural preservation.

Research implication: This research underscores the transformative potential of agritourism as a model for sustainable development, offering valuable insights for similar regions worldwide.

Originality/Value: Being Albania a small country, there is not much interest on narrowing research on it, but as SDGs imply, the system thinking is very important, no country, no place behind, there is just one Earth. The study can be interesting for other small regions, going on the same specifics as Albania, like other developing countries in the world.
Meaningful Social Studies Learning Practices in Islamic Elementary School Education: Case Study from Indonesia
Authors: Rachmadyanti Putri , Sumarmi  , Wahyono Hari , Pristiani Riska , Kiettikunwong Narong 
Published: January 2025

Objective: The primary issue in social studies education at Islamic Elementary Schools in Indonesia is the over-reliance on rote memorization, limiting student engagement and critical thinking. This study aims to explore how meaningful learning practices are implemented to enhance student participation and understanding in social studies classes.

Method: A qualitative case study approach was employed, involving semi-structured interviews with teachers and principals from Islamic Elementary Schools. Thematic analysis was used to analyze the data and identify key themes reflecting current practices and approaches.

Results and Discussion: The study identified three core themes: (1) systematic lesson planning that embeds Islamic values to create a holistic learning experience, (2) collaborative projects and outdoor learning activities that encourage practical exploration of maps and landscapes, and (3) differentiated learning approaches that cater to students' varying abilities and learning preferences. These strategies foster deeper engagement and bridge academic content with students' cultural and spiritual contexts.

Research Implications: The findings provide essential insights for educators and policymakers, emphasizing the importance of designing curricula that prioritize inclusivity, relevance, and student-centered approaches. Aligning pedagogical methods with developmental needs and local cultural frameworks enhances the quality of social studies education and ensures long-term retention and application of knowledge.

Originality/Value: This research highlights the integration of Islamic values as a cornerstone for meaningful social studies education, contributing to students' holistic development and promoting active learning environments that reflect the unique cultural context of Islamic Elementary Schools in Indonesia.
The Influence of Marketing Strategy, Service Quality, Trust, and Relationship Marketing on Residential Property Satisfaction SDG in Samarinda City
Authors: Aulianda Mega , Sudarmiatin  , Hermawan Agus , Winarno Agung 
Published: January 2025

Objective: This study focuses on the business relationship between SMEs providing building materials and residential property developers, by assessing the Business to Business (B2B) model. B2B involves transactions that occur either electronically or directly between two business entities, rather than between the business and the end consumer.

Theoretical Framework: This study examines variables such as marketing strategy, service quality, and trust from a B2B perspective, especially in the context of the interaction between SMEs providing building materials and residential property developers.

Method: A quantitative approach was used in this study, which involved testing the theory through variable measurements with numbers and data analysis using the Partial Least Square statistical procedure. The study population consisted of 608 residential property developers, with sampling conducted through the distribution of questionnaires.

Results and Discussion: The results of the study show that variables such as marketing strategy, service quality, trust, and Relationship Marketing have a positive and significant impact on residential property satisfaction in Samarinda City.

Research Implications: The advice given is for SMEs to improve their Customer Relationship Management (CRM) system, improve service quality, trust, and Relationship Marketing to increase customer satisfaction and loyalty.

Originality/Value: The originality of the theoretical model in this research contributes to the
development of RBV theory, as well as the implementation of dynamic resource capabilities in
SME.
Highten Discrete Mathematics Learning Through Gamified: A Sustainable Development Goals (SDG) Perspective
Authors: Rachmadi Pratiwi , Situmorang Robinson , Sukardjo Moch 
Published: January 2025

Objectives: This study aims to address challenges in engaging and motivating students in mathematics learning by integrating gamification aligned with Sustainable Development Goals (SDGs), particularly SDG 4: Quality Education.

Theoretical Framework: Drawing on the Dick and Carey instructional design model, the study develops a structured approach to gamifying mathematics education using the Quizizz application.

Method: A ten-stage development methodology is adopted, covering needs analysis, instructional design, iterative implementation, and evaluation, specifically tailored for first-semester students at IKPIA Perbanas Jakarta.

Results and Discussion: The findings indicate that gamification significantly enhances student engagement and comprehension, achieving a 95.83% accuracy rate in mathematics exercises. Discussions underscore the alignment of gamified tools with digital-native students' preferences and their integration into Learning Management Systems (LMS). Gamification complements traditional teaching methods, fostering interactive and effective learning experiences.

Research Implications: Gamification offers scalable models for embedding game mechanics into curricular designs, improving motivation and student-centered learning in higher education.

Originality/Value: This research highlights the transformative potential of gamification in higher education, contributing innovative insights into its application in mathematics education and its alignment with SDG 4.
Application of Crisp (Context-Responsive, Input, System, and Product Evaluation) Method to the Implementation of Differentiated Learning Models
Authors: Tapung Marianus 
Published: January 2025

Objective: The quality of Education is one of the strategic issues and entry points in achieving the SDGs. Evaluation of the learning model is a vital study to assess the success of an education program in developing countries.

Theoretical Framework: Evaluative Analysis of the Success of Implementing the Differential Learning Model using the basis of CRISP (Context-Responsive, Input, System, and Product Evaluation) theory with integrated assessment.

Method: This observational study uses an evaluative descriptive approach to examine the effectiveness of differentiated learning practices in Junior High School Driving Schools in East Manggarai. The research was conducted from March to October 2024, involving 416 respondents, including practitioners, supervisors, and stakeholders in the education sector. The collection uses questionnaire methods and structured interviews. Data analysis uses a quantitative approach using IBM SPSS software ver.25.

Results and Discussion: The results of the study on 4 phases include parameters 1) Context-Responsive; 2) Input; 3) System; and 4) Product gets a positive perception from the assessors in the field; several issues that need attention, including program sustainability, program funding sustainability, socioeconomic conditions, human resource capacity, and the development of teaching methods,

Research Implications: Evaluative analysis based on CRISP theory can be a role model that can reach and identify problems in implementing educational programs that are important on the agenda to achieve the SDGs.

Originality/Value: The findings of this study can contribute as an evaluative model in assessing the success of a learning program in developing countries, especially in the development of differential-based methods in developing countries.