bluuebunny/crossref_metadata_2025_split huggingface dataset:
La réindustrialisation des territoires ruraux peu denses ? L’implantation d’un projet ambitieux au défi des proximités
Authors: Ferru Marie , Texier Élodie 
Published: August 2023

Face à la réorganisation territoriale et à la compétition accrue entre les territoires, les villes rurales apparaissent particulièrement fragilisées. Nous interrogeons leurs capacités de rebond et l’importance de certaines ressources locales pour le retour d’activités économiques productives. A partir de l’analyse qualitative d’un projet de transformation de produits agroalimentaires biologiques, projet d’initiative privée qui « atterrit » dans une petite commune rurale de la Vienne, nous vérifions les atouts de la petite ville rurale et confirmons l’importance des ressources foncières (à bas coût et de qualité) et de la proximité physique immédiate entre acteurs dans l’émergence d’activités sur ces territoires. Nous soulignons également leur caractère non suffisant, la construction d’une proximité organisée pour une bonne gouvernance et un ancrage territorial du projet apparaissant indispensables.
Nouveaux modèles économiques et renouvellement productif à Romans-sur-Isère : à la recherche de la durabilité territoriale
Authors: Fompérie Florian , Maillefert Muriel 
Published: August 2023

Face à la désindustrialisation, la ville de Romans-sur-Isère s’est récemment appuyée sur une stratégie de redéploiement de ses activités autour d’un modèle patrimonialisé. Ce travail s’intéresse à la dimension transformatrice du modèle économique adopté en croisant deux paradigmes : celui des nouveaux modèles économiques et celui de l’économie circulaire. Il s’interroge sur le degré de transformation de ce modèle industriel à travers 5 expérimentations emblématiques. Ces expérimentations servent de point d’appui pour proposer et identifier les caractéristiques d’un modèle innovant. L’analyse permet ainsi de montrer les enjeux d’un changement de modèle vers un modèle sobre et serviciel.
L’image de l’oasis comme matériel de terrain
Authors: Carpentier Irène 
Published: August 2023

L’iconographie oasienne est riche et ancienne, mais son usage dans la recherche reste peu explicité. Revenant sur nos terrains de thèse, à Tozeur et Gabès en Tunisie, il s’agit ici d’interroger le rôle de la photo dans la construction de l’imaginaire territorial oasien, et de la recherche sur ces espaces. Matériel de terrain original, la photo dans les oasis constitue une ressource porteuse de discours divers sur le territoire, entre promotion d’un rêve touristique, documentation d’un paysage, ou support de sensibilisation à la dégradation environnementale du milieu. Nous reviendrons notamment sur la réappropriation de l’abondant corpus colonial au service d’une idéalisation des systèmes anciens, puis le processus de constitution d’un corpus « témoin » des dégradations environnementales dans un contexte de dynamisme associatif, et enfin la manière dont la recherche peut mobiliser ce matériel de terrain pour analyser et illustrer la diversité des formes de mise en valeur des territoires.
An Atlas of Grass Carp IgM+ B Cells in Homeostasis and Bacterial Infection Helps to Reveal the Unique Heterogeneity of B Cells in Early Vertebrates
Authors: Pan Yi-Ru , Wu Chang-Song , Zhong Ya-Qin , Zhang Yong-An , Zhang Xu-Jie 
Published: August 2023

Abstract
Teleost B cells are primitive lymphocytes with both innate and adaptive immune functions. However, the heterogeneity and differentiation trajectory of teleost B cells remain largely unknown. In this study, the landscape of grass carp IgM+ (gcIgM+) B cells was revealed by single-cell RNA sequencing. The results showed that gcIgM+ B cells mainly comprise six populations: (im)mature B cells, innate B cells, proliferating B cells, plasma cells, CD22+ cells, and CD34+ cells, among which innate B cells and proliferating B cells were uncommon B cell subsets with, to our knowledge, new characteristics. Remarkably, three functional IgMs were discovered in grass carp, and a significant percentage of gcIgM+ B cells, especially plasma cells, expressed multiple Igμ genes (Igμ1, Igμ2, and/or Igμ3). More importantly, through single-cell sorting combined with Sanger sequencing, we found that distinct VHDJH recombination patterns of Igμ genes were present in single IgM+ B cells, indicating that individual teleost B cells might produce multiple Abs by coexpressing rearranged IgM subclass genes. Moreover, the percentage of IgM1highIgM2highIgM3high plasma cells increased significantly after bacterial infection, suggesting that individual plasma cells might tend to produce multiple IgMs to resist the infection in teleost fish. In summary, to our knowledge, this study not only helps to uncover the unique heterogeneity of B cells in early vertebrates but also provided significant new evidence supporting the recently proposed “one cell–multiple Abs” paradigm, challenging the classical rule of “one cell–one Ab.”
Parental KAP and its Relation with the Quality of Life in Children with Epilepsy
Authors: Sadanandan Sanithamol A. , Shreedevi Athyadi U. , Padmanabha Hansashree 
Published: August 2023

Abstract

Background:
Epilepsy is a chronic disorder with recurrent unprovoked seizures which can affect children at any age. A child’s quality of life (QOL) is significantly impacted by an epilepsy diagnosis throughout their formative years. Adjustment and QOL for the child and family are highly correlated with parental knowledge, attitudes, and practices (KAP) regarding epilepsy.

Objectives:
Determining the association between parental KAP and the QOL of children with epilepsy (CWE) and to study the association between them.

Materials and Methods:
Using convenience sampling procedure, 30 CWE between the ages of 6 and 14—of either sex—and their 30 parents made up the sample. The knowledge, attitude, and practice (KAP) tool, which was given to parents, and the Quality of Life in Childhood Epilepsy Questionnaire-55 (QOLCE-55), which was given to CWE, were used to gather the data. Frequency distribution, percentage, and correlation coefficient tests were used to assess the measures.

Results:
There were statistically significant relationships between the QOL and KAP domains and parental education, domicile, and socioeconomic position. The cognitive, emotional, and social domains of QOL were adversely connected with the knowledge domain in KAP, but the physical domain was positively correlated. Parents’ behavior and physical QOL were found to be negatively correlated.

Conclusion:
Although educated parents had sufficient information and a positive outlook, there was a discrepancy between recommended and actual practice, and KAP has an impact on the QOL of CWE. Parental education initiatives may significantly improve understanding and promote healthy behaviors.
Hippocampal Volume in Children with Attention Deficit Hyperactivity Disorder and Speech and Language Delay
Authors: Dhikav Vikas , Parakh Manish , Pandey Kajal , Jangid Hemant , Khicher Pankaj 
Published: August 2023

Abstract

Introduction:
Hippocampus is a complex brain structure located deep in the temporal lobes of the brain. The structure has been implicated in several disorders related to cognition. Reports are emerging of its involvement in attention deficit hyperactivity disorder (ADHD). The current study was planned to assess the volume of the hippocampus in children with ADHD and speech and language delay with normal birth history using magnetic resonance imaging (MRI) of the brain.

Material and Methods:
MRI brain of 12 children (age range = 3–6 years) and 22 controls with clinical diagnosis of ADHD as per Diagnostic and Statistical Manual-5 were obtained in oblique coronal sequence (T1 weighted). The entire hippocampus formation was outlined manually using Image-J software available freely from www.freesurfer.com. Results were expressed as volume cubic millimeters ± SD.

Results:
Volumes of the hippocampi of children with ADHD were 2450.2 ± 667 mm3 (R) and 2505.8 ± 878.5 mm3 (L), respectively. The mean volume (bilateral) of the cases was 2478 ± 772.75 mm3. The right hippocampal volume of the controls was 3255.8 ± 1374.3 mm3 (R) and that of the left side was 3159.3 ± 1451 (L) mm3, respectively.

Conclusion:
Current study reported a substantial shrinkage (23%) of the left and right hippocampus in children with ADHD compared to controls.
Efficacy of stellate ganglion interventions for complex regional pain syndrome in the upper limb—A systematic review and meta-analysis
Authors: Purohit Gaurav , Bhandari Baibhav , Kumar Ajit , Talawar Praveen , Gupta Shiwam , Atter Pradeep 
Published: August 2023

ABSTRACT

Background and Aims:
Stellate ganglion (SG) interventions for treating upper limb complex regional pain syndrome (CRPS) have been reported in studies. However, more substantial evidence is required to reach a consensus on its analgesic efficacy. To the best of our knowledge, no systematic review demonstrating the effectiveness of SG intervention for upper limb CRPS has been reported. Hence, this meta-analysis was done to ascertain the efficacy of SG intervention in managing patients with upper limb CRPS.

Methods:
A database search of PubMed, Cochrane, Embase, Scopus and Google Scholar was done for articles published between January 2001 and December 2021. Two independent reviewers extracted data from the included studies, and the studies were evaluated for any potential risk of bias, and a meta-analysis was performed.

Results:
Eight studies were included in the qualitative synthesis, four were randomised controlled trials (RCTs), and the rest were non-RCTs. Six studies were assessed quantitatively. A significant reduction in pain scores post-intervention, up to two weeks, and four to 28 weeks after the procedure was observed, although the included studies exhibited marked heterogeneity. Qualitative analysis of these studies revealed an overall improvement in disability scores and functionality as assessed by an improved range of motion. Most studies reported no complications or only short-term minor complications after the procedure.

Conclusion:
Stellate ganglion interventions improve pain and disability scores with self-limiting short-term complications and no long-term complications. However, further studies with a large sample size are required to validate this treatment modality.
Conventional versus reverse insertion of i-gel® in overweight and obese patients – Interventional randomised controlled trial
Authors: Ahuja Sonali , Kaur Gurpreeti , Garg Kamakshi , Grewal Anju 
Published: August 2023

ABSTRACT

Background and Aims:
The supraglottic airway device, i-gel, is used in obese patients for short- to medium-duration surgical procedures. Insertion techniques have contributed to the successful and proper placement of i-gel in the first attempt. This study aims to compare two techniques for successfully inserting i-gel in the first attempt in overweight and obese patients as measured by oropharyngeal leak pressure (OLP).

Methods:
This interventional, randomised, controlled study was conducted after ethical approval, and trial registration in overweight and obese patients. Patients were randomised into two groups: In Group C, the conventional technique was used, while in Group R, the reverse technique was used to insert i-gel. OLP, successful placement, required manipulations, time taken for insertion, number of attempts, and intraoperative and postoperative complications were studied. The collected data were analysed statistically.

Results:
The mean OLP (30.46 ± 3.76 vs. 32.12 ± 3.10 mmHg, P = 0.018) and the mean time of insertion (16.42 ± 1.86 vs. 13.98 ± 1.97 s, P = 0.001) for conventional and reverse techniques, respectively, were statistically significant and favourable for Group R compared to Group C. Successful placement of i-gel at the first attempt, ease of insertion, number of attempts and all the manipulations except withdrawal and advancement were comparable in both the groups. No postoperative complications were noted.

Conclusion:
The reverse technique significantly favoured the actual OLP values and the mean insertion time. Successful placement of i-gel at the first attempt was observed with both conventional and reverse techniques.
Minimum effective dose of oxytocin bolus during the caesarean section for patients at high vs low risk of uterine atony: A non-randomized, dual-arm, dose-finding prospective trial
Authors: Tyagi Asha , Deep Sonali , Salhotra Rashmi , Malhotra Rajeev , Singla Anshuja 
Published: August 2023

ABSTRACT

Background and Aims:
There are scanty data for oxytocin dose in patients at high risk of uterine atony. We aimed to compare the effective dose (ED) 90 of oxytocin for adequate uterine tone during the caesarean section in patients at high-risk vs low-risk uterine atony.

Methods:
This dose-finding study was undertaken after ethical approval in non-labouring women aged >18 years with pre-defined risk factors for uterine atony (high-risk group) vs those without such factors (low-risk group) (n = 39 each). Starting dose of oxytocin in the first patient of low-risk and high-risk groups was 1 and 3 IU, respectively. Achieving adequate uterine tone at 3 min of oxytocin bolus was designated ‘success’, while inadequate tone constituted ‘failure’. If the response was ‘failure’, the dose of oxytocin was increased for the next patient by 0.5 or 0.2 IU (high- and low-risk groups, respectively). In case of a successful response, the dose for the next patient was decreased with a probability of 1/9 using the same dosing intervals or otherwise kept unchanged.

Results:
The ED90 (95% CI) of oxytocin bolus was 4.7 (3.3–6.0) IU for the high-risk group and 2.2 (1.3–3.2) IU for the low-risk group (P = 0.044). Oxytocin-associated tachycardia (P = 0.247) and hypotension (P = 0.675) were clinically greater for the high-risk vs low-risk group but statistically similar.

Conclusion:
Non-labouring patients with high-risk factors for uterine atony require a greater dose of initial oxytocin bolus to achieve adequate uterine tone during the caesarean section compared to those without risk factors.
Evaluation of Radiation Exposure to the Patients Undergoing Positron Emission Tomography/Computed Tomography-Guided Biopsies
Authors: Deva Krishnapriya , Rana Nivedita , Kumar Rajender , Mittal Bhagwant Rai 
Published: August 2023

Purpose:
We aimed to evaluate the radiation exposure to patients undergoing positron emission tomography/computed tomography (PET/CT)-guided biopsies.

Materials and Methods:
Patients undergoing PET/CT-guided biopsy were recruited prospectively from October 2019 to April 2020. PET/CT-guided biopsy from a tracer avid site was done using an automated-robotic-arm 1 h after intravenous injection of F-18-fluorodeoxyglucose (FDG) (2-5 mCi) or Ga-68-PSMA (1–4 mCi). Regional CT-images were acquired for biopsy planning and confirmation of needle placement. The internal radiation exposure due to the PET component was estimated using the value of activity injected and dose-coefficient for FDG and PSMA. The external radiation exposure due to the CT component was estimated using the value of dose length product and organ coefficients conversion factor. The total effective dose during the procedure was calculated by adding exposure due to both CT and PET components. Percentage contribution from CT and PET component to total effective dose was compared using a paired t-test.

Results:
A total of 101 patients (76 males) were recruited for PET/CT-guided biopsy using FDG (n = 79) and PSMA (n = 22). The mean effective-dose due to PET and CT components and total effective-dose was 2.49 ± 1.02 mSv, 2.35 ± 1.03 mSv and 4.83 ± 1.90 mSv, respectively, for FDG-guided procedures and 1.60 ± 0.57 mSv, 3.06 ± 1.36 mSv, and 4.66 ± 1.37 mSv for Ga-68-PSMA-guided procedures. The percentage contribution of PET and CT in total effective-dose was comparable in F-18-FDG and Ga-68-PSMA PET/CT-guided biopsy procedures; however, for Ga-68-PSMA PET/CT-biopsies, CT contributed a higher radiation dose than PET component.

Conclusion:
PET/CT-guided biopsy is a safe interventional procedure, and radiation exposure to the patients was less than routine whole-body PET/CT-imaging.
Early Demonstration of Spontaneous Perinodal Lymphangiogenesis by Lymphoscintigraphy after Vascularized Lymph Node Transplantation - A Pilot Study
Authors: Subramanyam Padma , Janarthanan R , Palaniswamy Shanmuga Sundaram 
Published: August 2023

Background:
Despite the lymphatic system being so important and extensive, the field of lymphatic diseases, research is still very young. Lymphedema is a progressively debilitating condition with no known “cure.” Specific pathologies that could benefit from improved lymphatic drainage by advanced super surgical techniques or engineered tissue transfer are being sought. Microsurgical techniques like lymphovenous bypass and anastomosis have spurred interest as they tend to physiologically restore the damaged lymphatic channels and may be a key to permanent cure. The latest in the field is vascularized lymph node transfer (VLNT), indicated in post mastectomy or other post operative settings producing disruption of regional lymphatic channels and draining lymph nodes. Autologous healthy lymph nodes are transferred along with surrounding fat and vascular pedicle to the affected limb in a bid to promote lymphangiogenesis. Lymphoscintigraphy (LS) is a simple, noninvasive nuclear technique used in identifying upper or lower limb lymphatic dysfunction and obstruction with a high degree of sensitivity. Quantitative LS is extremely useful in follow-up assessment of lymphedema postmanual lymphatic drainage (MLD) or other forms of medical management.

Aim:
We hypothesize that LS can document perinodal lymphangiogenesis post VLNT.

Material and Methods:
Three cases of acquired lymphedema (suspected filariasis and postmastectomy conditions) who underwent VLNT in our institute were prospectively studied with LS. The imaging findings highlight the subtle lymphatic regeneration along with the vascularized graft in all three patients during the early postoperative period.

Conclusion:
This is the first (pilot) study documenting early spontaneous perinodal lymphangiogenesis after VLNT in human subjects.99mTc Nanocolloid LS has been found to be incremental in demonstrating early lymphangiogenesis.
Correlation between Interlimb Coordination with Dynamic Balance and Cognition among Geriatric Population of South Delhi
Authors: Minhal Khan , Hammad A Siddiqui , Charu Chhabra , Himani Kaushik 
Published: August 2023

Context:
Aging involves an overall deterioration of sensory functions, affecting the coordinated behavior, and suggesting a decline in the quality of afferent information from the periphery. Extra mental effort is required for the control of these movements and performing complex tasks requiring control of balance.

Aim:
The research was undertaken to determine the correlation between interlimb coordination with dynamic balance and cognition in geriatrics.

Setting and Design:
Cross-sectional study was done on geriatric people from Rehabilitation Center, Jamia Hamdard, Delhi.

Subjects and Methods:
A total of 35 healthy geriatrics were recruited from South Delhi by convenience sampling, based on the inclusion criteria of the study. Ethical approval was obtained from the ethics committee of the university and signed informed consent was obtained before the study. All the participants were assessed for interlimb coordination, dynamic balance, and cognition by Purdue Pegboard Test, Berg balance test, and mini–mental state examination, respectively, at Rehabilitation Center, Jamia Hamdard, Delhi.

Statistical Analysis:
Statistical analysis for correlation was performed through statistical software IBM SPSS Statistics 21.0 and the Pearson correlation test was used with a significance level set at 0.01.

Results:
Mean changes revealed the correlation between interlimb coordination and cognition (P = 0.000). Interlimb coordination and balance did not show any correlation (P > 0.01), and there was no adverse event during the study.

Conclusion:
It was concluded from the study that interlimb coordination is related to cognition and not to dynamic balance in healthy geriatric people.
Development of an Indian nomogram for predicting extracapsular extension in prostate cancer
Authors: Ravi Chandran , Sanjeevan Kalavampara V. , Thomas Appu , Pooleri Ginil Kumar 
Published: August 2023

Introduction:
The aim of our study was to develop a new Indian nomogram to estimate pathologic extracapsular extension (ECE) risk in prostate cancer, by including PI-RADS v1-based magnetic resonance imaging (MRI) ECE risk score to the clinical variables used in the Partin nomogram (PN).

Materials and Methods:
We analyzed 273 patients who underwent MRI of prostate and radical prostatectomy (RP). Univariate and multivariate logistic regression analyses were performed to identify predictors of ECE. We calculated the area under the receiver operating characteristic curve (AUC) for three variables used in PN and MRI ECE risk score, and a new nomogram was designed using binary logistic regression. Calibration curves assessed the agreement between the actual ECE risk and the predicted probability of the new nomogram.

Results:
Out of 273 patients, 123 patients (45.1) had ECE on MRI, whereas 136 patients (49.8) had ECE on final pathology. The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of MRI for predicting ECE were 76.6, 66.9, 70.0, 73.9, and 71.7 (confidence interval 95), respectively. Multivariate logistic regression analyses showed that clinical T-stage (cT), Gleason score (GS), and MRI ECE risk score remained significant. The highest and the lowest values of the AUC for single variables were 0.748 (MRI ECE risk score) and 0.636 (cT stage), respectively, and AUC for PN was 0.67. New nomogram designed using R statistical package has higher predictive accuracy (0.826) compared to PN (0.67) and good calibration.

Conclusions:
MRI adds incremental value to PN. A new Indian nomogram can help in the decision-making process of nerve-sparing RP. This nomogram should be used with caution as validation is pending and will require further studies.