bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chronic Vitamin D Deficiency and its Effects on Human Health: A Literature Review
Authors: Georgaki Maria Nefeli , Georgakis Charalampos , Charalambous Marianna , Mamisi Katerina , Karachrysafi Sofia 
Published: September 2023

Abstract

Introduction:
Vitamin D plays a vital role as an essential nutrient for human health, but a significant number of people worldwide have a deficiency in this vitamin. Chronic Vitamin D deficiency has been linked to several adverse health outcomes, including musculoskeletal disorders, cardiovascular disease (CVD), cancer, and autoimmune disorders.

Methodology:
We conducted a comprehensive literature search using academic databases, including PubMed, MEDLINE, Scopus, and Google Scholar. The search terms included “Vitamin D deficiency,” “chronic disease,” “musculoskeletal disorders,” “cardiovascular disease,” “cancer,” and “autoimmune disorders.” We focused on articles that examined the link between chronic Vitamin D deficiency and various health outcomes.

Results:
Studies suggest that Vitamin D deficiency may contribute to several chronic diseases, including osteoporosis, osteoarthritis, hypertension, and CVD. Evidence indicates that inadequate levels of Vitamin D can increase the risk of certain types of cancer, such as colorectal and breast cancer. Studies have also found that people with autoimmune disorders, such as type 1 diabetes, multiple sclerosis, and rheumatoid arthritis, have lower levels of Vitamin D compared to healthy individuals.

Conclusions:
The findings of this literature review highlight the importance of identifying and treating chronic Vitamin D deficiency to prevent or manage associated health conditions. Strategies to prevent Vitamin D deficiency include increased sun exposure, dietary changes, and Vitamin D supplementation. Regular screening for Vitamin D deficiency may also be necessary, particularly in high-risk populations. Clinicians should consider Vitamin D status when evaluating patients with chronic diseases and take appropriate steps to address any deficiencies.
An Early-stage Comparison of Functional Outcomes Following Robotic-assisted Versus Conventional Total Knee Arthroplasty: A Systematic Review and Meta-analysis
Authors: Parel Philip M. , Manyak Grigory A. , Carvajal Jaime A. , Abraham Thomas , Al Rashid Mamun 
Published: September 2023

Introduction:
Conventional total knee arthroplasty (cTKA) is used to relieve pain and restore knee function and stability. Robotic-assisted TKA (rTKA) was introduced to improve the placement of surgical implants, decrease postoperative complications, and improve implant longevity. To date, studies examining functional outcomes and patient-reported pain between rTKA and cTKA in the short-term postoperative period are limited, and a meta-analysis of such early-stage outcomes has yet to be accomplished. Our study aims to evaluate the differences in function, alignment, and pain between rTKA and cTKA within 6 months postoperatively through meta-analysis.

Materials and Methods:
A literature search of the PubMed and Cochrane electronic databases was performed in December 2021 with Medical Subject Headings and search terms limited to “knee replacement,” “knee arthroplasty,” and “robotic knee surgery.” Subsequent analysis was conducted on all retrieved studies written in English.

Results:
Thirteen clinical studies were considered for systematic review, of which nine were included in meta-analysis. 1,336 cases of TKA were analyzed: RTKA (n = 618) and cTKA (n = 718). There were no significant differences between rTKA and cTKA in range of motion (mean difference,-0.08°; P = 0.55), functional score of the Knee Society Score (mean difference, 0.04; P = 0.78), oxford knee score (mean difference, −0.04; P = 0.81), and Functional score of the western ontario and mcmaster universities osteoarthritis index (WOMAC-F) (mean difference, −0.42; P = 0.41). There were no significant pain differences in Short Form Health Survey Bodily Pain (mean difference, −0.08; P = 0.64) and pain score of the WOMAC (WOMAC-P) (mean difference, −0.25; P = 0.47). However, rTKA subjects achieved more accurate mechanical axis alignment than cTKA subjects (mean difference, −0.50°; P < 0.01).

Conclusion:
Although limb alignment correction is more accurate in rTKA than cTKA, functional and pain metrics are comparable between the two procedures within 6 months’ follow-up, suggesting no added clinical benefits for rTKA versus cTKA.
Speckle Tracking Strain Echocardiography: What Sonographers Need to Know!
Authors: Davis Ashlee M. , Adams David , Venkateshvaran Ashwin , Alenezi Fawaz 
Published: September 2023

Introduction:
Strain is a unitless measurement of dimensional or deformational change; speckle-tracking echocardiography is the most widely used technique to assess strain, with demonstrated clinical utility in a variety of settings.

Objectives:
This paper reviews the diagnostic and prognostic impact of echocardiographic assessment of left ventricle myocardial strain and what sonographers need to know in a daily practice.

Methods:
This paper have the most updated American society of echocardiography recommendations on a speckle tracking strain echocardiography, and included experiences of a large academic center, standardization as well as tips needed to perform a strain in a daily clinical practice.

Conclusion:
With good feasibility, reproducibility and evidence in support, speckle tracking strain echocardiography can be used as a standard echocardiography parameter in clinical practice.
Problems for generalized Monge–Ampère equations
Authors: Enache Cristian , Porru Giovanni 
Published: September 2023

AbstractThis paper deals with some Monge–Ampère type equations involving the gradient that are elliptic in the framework of convex functions. First, we show that such equations may be obtained by minimizing a suitable functional. Moreover, we investigate a P-function associated with the solution to a boundary value problem of our generalized Monge–Ampère equation in a bounded convex domain. It will be shown that this P-function attains its maximum value on the boundary of the underlying domain. Furthermore, we show that such a P-function is actually identically constant when the underlying domain is a ball. Therefore, our result provides a best possible maximum principles in the sense of L. E. Payne. Finally, in case of dimension 2, we prove that this P-function also attains its minimum value on the boundary of the underlying domain. As an application, we will show that the solvability of a Serrin’s type overdetermined problem for our generalized Monge–Ampère type equation forces the underlying domain to be a ball.
A Novel Nested Multiplex Polymerase Chain Reaction Assay for Malaria Diagnosis Using the Hydroxymethyl Dihydropterin Pyrophosphokinase-Dihydropteroate Synthase (hppk-dhps) Gene
Authors: Chaianantakul Natpasit , Sungkapong Tippawan , Nikhomkham Kanokwan , Sanseewong Kansuda , Kornsang Sawanya 
Published: September 2023

ABSTRACT.
There are many techniques for malaria diagnosis. Currently, the nested polymerase chain reaction (PCR) method based on a small subunit ribosomal RNA gene (18S rRNA) has been used as a confirmatory method. However, this method is time-consuming, laborious, and costly. Therefore, the objective of this study was to develop nested multiplex PCR for Plasmodium species identification using the dihydropterin pyrophosphokinase-dihydropteroate synthase (hppk-dhps) gene. Genus- and species-specific primers for the hppk-dhps gene were designed. The performance of the novel nested multiplex PCR was compared with 18S rRNA nested PCR. A total of 115 blood samples were used in this study, including 84 infected samples and 31 uninfected samples. Analysis of the blood samples by nested multiplex PCR targeting the hppk-dhps gene identified 81 infected cases. The level of agreement between this novel method and 18S rRNA nested PCR was 97.4%. Further, the novel method successfully detected all human malaria parasites except Plasmodium ovale and detected mixed Plasmodium falciparum/Plasmodium vivax infections. The sensitivity and specificity obtained from this novel method were 96.4% and 100%, respectively. The limit of detection of the hppk-dhps nested multiplex PCR for P. falciparum and P. vivax was 500 parasites/µL and 4 parasites/µL, respectively. The lowest parasite gDNA detected by this method was 0.5 ng/µL for P. falciparum and 0.1 ng/µL for P. vivax. These results corroborate that the hppk-dhps gene is a novel amplification target for the detection of human malaria. This novel target PCR-based method is a beneficial approach for malaria diagnosis, as well as species identification and differentiation.
Understanding Sociodemographic Factors and Reasons Associated with COVID-19 Vaccination Hesitance among Adults in Tanzania: A Mixed-Method Approach
Authors: Msuya Hajirani M. , Mrisho Gumi A. , Mkopi Abdallah , Mrisho Mwifadhi , Lweno Omar N. , Ali Ali M. , Said Ali H. , Mihayo Michael G. , Mswata Sara S. , Tumbo Anneth M. , Mhalu Grace , Jongo Said A. , Kassim Kamaka R. , Nyaulingo Gloria D. , Temu Silas G. , Kazyoba Paul E. , Haruna Hussein , Kishimba Rogath , Kassa Hellen , Mwangoka Grace W. , Abdulla Salim 
Published: September 2023

ABSTRACT.
Although studies on COVID-19 vaccine hesitancy are being undertaken widely worldwide, there is limited evidence in Tanzania. This study aims to assess the sociodemographic factors associated with COVID-19 vaccine hesitancy and the reasons given by unvaccinated study participants. We conducted a mixed-method cross-sectional study with two components—health facilities and communities—between March and September 2022. A structured questionnaire and in-depth interviews were used to collect quantitative and qualitative data, respectively. A total of 1,508 individuals agreed to participate in the survey and explained why they had not vaccinated against COVID-19. Of these participants, 62% indicated they would accept the vaccine, whereas 38% expressed skepticism. In a multivariate regression analysis, adult study participants 40 years and older were significantly more likely to report not intending to be vaccinated (adjusted odds ratio [AOR], 1.28; 95% CI, 1.01–1.61; P = 0.04) than youth and middle-aged study participants between 18 and 40 years. Furthermore, female study participants had a greater likelihood of not intending to be vaccinated (AOR, 1.51; 95% CI, 1.19–1.90; P = 0.001) than male study participants. The study identified fear of safety and short-term side effects, and lack of trust of the COVID-19 vaccine; belief in spiritual or religious views; and belief in local remedies and other precautions or preventive measures as the major contributors to COVID-19 vaccine hesitancy in Tanzania. Further empirical studies are needed to confirm these findings and to understand more fully the reasons for vaccine hesitancy in different demographic groups.
Case Report: Nocardia amamiensis Infection Leading to Worsening of Chronic Obstructive Pulmonary Disease Symptoms in an Elderly Man
Authors: Kanakan Ahalya , Kumar Amit , Kaur Upinder , Narwade Prity , Rain Zinnu , Yadav Nidhi , Kumar Ishan , Kumar Deepak , Chakrabarti Sankha Shubhra 
Published: September 2023

ABSTRACT.
Nocardiosis is a rare opportunistic infection mostly affecting the lungs, brain, or skin of immunocompromised individuals. Most pulmonary nocardiosis patients present with nonspecific clinical features such as productive cough, exertional dyspnea, and fever. The disease is uncommonly suspected, especially in tuberculosis-endemic regions, and clinical diagnosis is often delayed, resulting in high mortality. Pulmonary nocardiosis in apparently immunocompetent individuals is uncommon. Here, we present the case of an elderly gentleman with a background history of poorly controlled diabetes but no history of systemic steroid use who presented with worsening symptoms of chronic obstructive pulmonary disease in the form of productive cough and dyspnea. The patient had diffuse crepitations in bilateral lung fields and an arterial oxygen saturation of 86% at admission. Sputum microscopy revealed gram-positive filamentous bacteria that could be successfully cultured and identified as Nocardia amamiensis on 16S ribosomal RNA sequencing. Contrast-enhanced computed tomography of the lungs revealed cavitary nodules and consolidation. The patient responded well to treatment with specific antibiotics based on sensitivity patterns. Because of the nonspecific clinical and radiological findings in pulmonary nocardiosis, a high index of suspicion is required, especially in tuberculosis-endemic regions.
Türkiye’de Hemşirelik Öğrencilerinde COVID-19 Aşı Okuryazarlığı ile Sosyodemografik Özelliklerin Aşı Tutumlarına Etkisi
Authors: YILDIRIM GÖKŞEN Dicle Filiz , ULUDAĞ Elif , ÖZKAN Sevgi 
Published: September 2023

Giriş: COVID-19 pandemisi küresel bir sağlık sorunudur. Bu salgının kontrol altına alınabilmesinde aşılama önem taşımaktadır. Ancak toplumda aşı tereddütlerine neden olan pek çok neden vardır. Bu nedenlere COVID-19 aşısıyla ilgili asılsız bilgi ve söylemler örnektir. Toplumun aşıya yönelik doğru bilgi kaynaklarından olan hemşirelerin ve hemşirelik öğrencilerinin aşıya yönelik tutumu da aşılama oranlarını etkileyebilecek güçtedir. Bu nedenle sağlık hizmeti sunacak olan hemşirelik öğrencilerinin aşı okuryazarlığının ve sosyodemografik özelliklerinin aşı tutumlarına etkisi incelemek önemlidir.
Amaç: Hemşirelik öğrencilerinin COVID-19 aşı okuryazarlığının ve sosyodemografik özelliklerinin COVID-19 aşı tutumlarına etkisini incelemektir.
Yöntem: Araştırma tanımlayıcı ve ilişkisel niteliktedir. Veri toplama formu; tanıtıcı bilgi formu, COVID-19 aşı okuryazarlığı ölçeği ve COVID-19 aşısına yönelik tutumlar ölçeğinden oluşmaktadır. Veri toplama formu, hemşirelik öğrencilerinin haberleşme gruplarında çevrimiçi olarak paylaşılmıştır. Araştırmaya 503 hemşirelik öğrencisi dahil edilmiştir. Veriler, SPSS 25 paket programı ile tanımlayıcı istatistikler ve pearson korelasyon kullanılarak analiz edilmiştir.
Bulgular: Öğrencilerin COVID-19 aşı tutumlarını cinsiyet, baba eğitim düzeyi ve olunan aşı türü etkilemektedir. COVID-19 aşı okuryazarlığının ise aşı tutumunu olumlu yönde etkilediği belirlenmiştir.
Sonuç: Hemşirelik öğrencilerinin COVID-19 aşısına karşı olumlu tutum geliştirmesinde doğru bilgiye ulaşma becerilerinin desteklenmesi, COVID-19 aşısına yönelik eğitimlerin güncel tutulması ve ebeveynlerinin de bilgilendirilmesi aşılama oranlarına katkı sağlayacaktır.
Сторінка історичного досвіду мирних переговорів під час війни: дипломатична місія УНР до Москви на початку 1919 р.
Authors: Солдатенко В.Ф. 
Published: September 2023

У статті ставиться завдання привернути увагу до однієї з мало досліджуваних сторінок вітчизняного дипломатичного досвіду – спроб Української Народної Республіки досягти миру у відносинах з Російською Соціалістичною Федеративною Радянською Республікою, загасити полум’я Громадянської війни на початку 1919 р. Доводиться констатувати, що в наявній історіографії з різних причин історія здійснення спеціальної дипломатичної місії УНР до Москви у січні – лютому 1919 р. не аналізувалася достатньо предметно і всебічно, хоча фактичний матеріал дає доволі значні можливості для конкретних висновків щодо можливостей використання уроків минулої практики для успішного здійснення завдань нинішнього надзвичайно відповідального етапу історичного поступу. Проблема видається тим значущою, що з неминучістю породжує умоглядні паралелі між нинішнім днем і подіями більш як сторічної давнини.
Model Pemberdayaan BUMDES Dalam Rangka Meminimalisir SDGs Desa Pasca Undang-Undang Cipta Kerja
Authors: Suryo Kencono Pramukhtiko , Ridho ‘Ubbadurrohman Muhamad Syah , Farhan Adijaya Mohammad 
Published: September 2023

Setiap orang mendambakan pekerjaan yang layak, maka berimpact terhadap peningkatan kesejahteraan ekonomi masyarakat. dalam prespektif undang-undang No. 13 tahun 2003 tentang Ketenagakerjaan diacu dalam pasal 96 mengatur terkait daluarsanya suatu kewajiban pemberi kerja untuk memberikan gaji/upah yang mana daluarsanya yaitu 2 tahun bila lebih dari 2 tahun maka kewajiban si perberi kerja untuk memberi gaji/upah akan hilang karena sudah lewat dari masa daluarsa tersebut. Yang mana telah dihapuskan dalam UU Cipta Kerja yang berdampak positif kepada para buruh/pekerja agar hak-haknya dipenuhi oleh pihak pemberi kerja.. Berbeda pengaturan di dalam UU Cipta Kerja, lebih menguntungkan para pekerja atau buruh. Tujuan penelitian ini untuk menganalisa inovasi UU Cipta Kerja terhadap para pekerja/buruh para buruh terkait SDGs Desa untuk mendapatkan Pekerjaan yang layak dan lebih sejahtera, selain itu pemberdayaan melalui BUMDES. Metode yang digunakan dalam penelitian ini dilakukan menggunakan metode yuridis normative yang mengkaji tentang permasalahan hukum dengan pendekatan konsep dan pendekatan peraturan perundang- undangan yaitu Undang- Undang No. 13 tahun 2003, Undang Undang No .6 Tahun 2023 tentang Cipta Kerja. Hasil Penelitian menunjukkan bahwa peningkatan SDGs Desa terkait pengurangan pengangguran, kemiskinan melalui pem-berdayaan masyarakat Desa (keberadaan BUMDES) sehingga menjadikan masyarakat menjadi mandiri dan sejahtera, adanya UU Cipta kerja buruh diberlakukan lebih manusiawi terhadap hak- hak yang akan diterima oleh para pekerja/ buruh. Rekomendasi dari penelitian ini segera membentuk Perdes terkait dengan pemberdayaan ekonomi bagi Masyarakat Desa.
Pengaruh Aspek Fundamental Dan Teknikal Terhadap Harga Saham Perusahaan Perbankan 2019-2021
Authors: Fadillah Alia Nur 
Published: September 2023

In investing in shares is not just about including capital into a company, but it is necessary to conduct an analysis to find out the performance of the company, especially in fundamental and technical analysis. The fundamental factors used are variables Earnings Per Share while the technical factors used vary Trading volume, market capitalization, and book value to the market.This study was conducted with the aim of determining the influence of variables Earning Per Share, Trading Volume, Market Capitalization and Book to Market Value on the Stock Price of the Banking Sector listed on the Indonesia Stock Exchange in 2019-2021. This study used a quantitative approach with purposive sampling method. The data used are secondary data and the analysis methods used are panel data regression and multiple linear regression. The results of this study show that partially the variables Earning Per Share, and Market Capitalization have a significant positive effect on stock prices while the variables Trading Volume and Book to Market Value do not have a significant effect on stock prices. And simultaneously the variables Earnings Per Share, Trading Volume, Market Capitalization and Book to Market Value have a significant effect on stock prices.
OITO VÍCIOS DA DOCÊNCIA NO ENSINO DA LEITURA
Authors: Silva Caroline Belchior 
Published: September 2023

Esta resenha busca apresentar a obra das psicólogas e mestres em Educação Ana Carolina Carvalho e Josca Ailine Baroukh, que também atuam como formadoras de professores e gestores das redes públicas e privadas de educação. Com o objetivo de explorar as oito práticas docentes que costumam ser empregadas durante o ensino da leitura literária na educação infantil e anos iniciais. Entretanto, essas são usadas de forma equivocada e não auxiliam no alcance do objetivo desejado.
Assessment of Chemosit River pollution with urbanization of Chemosit Centre, Kericho County, Kenya
Authors: Cherotich Emily , Nyabaro Obed , Rayori Douglas Mosoti , Evans Kenanda Okemwa 
Published: September 2023

Water that is free of contaminants is necessary for life. River Chemosit passes through Chemosit Centre. The centre population is increasing due to numbers of learning institutions, medical facilities, businesses, industries and social facilities. This population has put pressure on the available clean water resources and waste management facilities. Inadequate waste management has led to environmental pollution including river Chemosit. The river pollution is negatively impacting the water quality presenting threats to the public's health and aquatic ecosystem. The study assessed the contribution of Chemosit Centre to pollution of river Chemosit. The study was carried out from August, 2021 to January, 2022. Water samples were collected and analysed for physico-chemical parameters. pH, temperature, Electrical conductivity, DO, and TDS measured in situ using calibrated portable professional series (YSI) multi-parameter meter model 35C, and UV-VIS spectrophotometer for sulphates, phosphates, and nitrates. The data was analysed using the statistical package SPSS, version 22. The software was used for computing descriptive statistics, ANOVA, and correlation coefficients. Spatially, the mean values for parameters were 7.0 ± 0.05 (pH), 24.15 °C ± 0.18 (temperature), 1187.94 μScm-1 ± 30.84 (electrical conductivity), 8.99 mgL-1 ± 0.06 (DO), 1460.06 mgL-1 ± 69.14 (TDS), 0.08 mgL-1 ± 0.005 (sulphates), 0.40 mgL-1 ± 0.01 (phosphates), and 1.6 mgL-1 ± 0.09 (nitrates). Seasonally, the means of pH, temperature, EC, and TDS, sulphates, and phosphates were significantly different between the two seasons except for DO, and nitrates. The means for pH, EC, sulphates and nitrates were within the WHO guidelines for domestic water use. The Correlation coefficient analysis for physico-chemical parameters indicates strong positive and negative relationship. In conclusion, river Chemosit is receiving pollutants from diffuse sources in addition from Chemosit Centre. The sources include effluent discharge from domestic and industrial sources and other human activities in the riparian zones along the river path. Therefore, preventing further pollution and complying with the NEMA and WHO standards for water usage, there is need for water quality monitoring.
Caracterización física y química de dos biocarbones obtenidos en diferentes condiciones de pirólisis
Authors: Gaona Chanalata Jose , Barrezueta-Unda Salomón 
Published: September 2023

El propósito de esta investigación fue comparar las propiedades físicas y químicas de dos biocarbones en diferentes condiciones de pirólisis. En un reactor pirolítico se obtuvieron los biocarbones a partir de cáscara de cacao (BCA) y estiércol bovino (BSB). Las condiciones de pirólisis fueron: 200ºC/60 minutos; 250ºC/30 minutos(E2); 300ºC/30 minutos. El biocarbón se dejó enfriar, para luego tamizar, proceder con los análisis. El mayor rendimiento del BCA fue de 35,56% y del BSB de 71,11%. Los valores de pH de todos los ensayos fueron altamente alcalinos con rangos de 8,23 – 10,04. En la prueba de hidrofobicidad los valores fueron: 65,73 s biocarbón de cacao y 228,3 s biocarbón de bovino. El mayor porcentaje de ceniza fue el estiércol bovino con 89,94 %. El análisis de Infrarrojo indicó picos de grupos funcionales carboxílicos en ambos biocarbones a 300ºC por 30 minutos.
NANOTECHNOLOGY: A CONSCISE VIEW
Authors: Oyubu, Akpovi Oyubu  , Nwabueze, Christopher Anayo  
Published: September 2023

Nanotechnology, a multifaceted subject area of applicative devices that involves the Engineering of functional systems at the molecular level is considered the nerve centre of technological advancement of the 21st century and beyond. This field that focuses on controlling the configuration and exploiting the exclusive characteristics of Nano-materials having not less than one dimensional volume of material between 1nm to 100nm to produce nano-scale devices, components and systems is repeatedly seen as an emerging technology which could be employed to enhance current products and processes. This paper which is essentially a review discusses Nanotechnology, its development, impact, applications and advances.
Keywords: Nanotechnology, Nano-scale, Composites, Nano-materials, Nano-devices.