bluuebunny/crossref_metadata_2025_split huggingface dataset:
A neonicotinoid pesticide alters Drosophila olfactory processing
Authors: Tatarko Anna R. , Leonard Anne S. , Mathew Dennis 
Published: January 2023

Abstract
Neonicotinoid pesticides are well-known for their sublethal effects on insect behavior and physiology. Recent work suggests neonicotinoids can impair insect olfactory processing, with potential downstream effects on behavior and possibly survival. However, it is unclear whether impairment occurs during peripheral olfactory detection, during information processing in central brain regions, or in both contexts. We used Drosophila melanogaster to explore the potential for neonicotinoids to disrupt olfaction by conducting electrophysiological analyses of single neurons and whole antennae of flies exposed to the neonicotinoid imidacloprid (IMD). Our results demonstrated that IMD exposure significantly reduced the activity of a single focal olfactory neuron and delayed the return to baseline activity of the whole antenna. To determine if IMD also impacts olfactory-guided behavior, we compared flies’ relative preference for odor sources varying in ethanol content. Flies exposed to IMD had a greater relative preference for ethanol-laced pineapple juice than control flies, demonstrating that neuronal shifts induced by IMD are associated with changes in relative preference. Given the interest in the sensory impacts of agrochemical exposure on wild insect behavior and physiology, we highlight the potential of Drosophila as a tractable model for investigating the effects of pesticides at scales ranging from single-neuron physiology to olfactory-guided behavior.
New native Bacillus thuringiensis strains induce high insecticidal action against mosquito larvae and adults
Authors: Ma Xinmin , Hu Jianjian , Ding Chengsong , Portieles Roxana , Xu Hongli , Gao Jingyao , Du Lihua , Gao Xiangyou , Yue Qiulin , Zhao Lin , Borrás-Hidalgo Orlando 
Published: January 2023

Abstract
Mosquitoes of many species are key vectors in disease transmission, causing millions of fatalities worldwide each year. Insecticidal formulations based on Bacillus thuringiensis have been considered one of the most effective, ecologically safe, and long-lasting methods of managing insect pests. We established the isolation, identification, genetic characterization, and biological function of novel B. thuringiensis strains with strong control efficacy on mosquitoes. A collection of eight B. thuringiensis strains was isolated and identified as containing genes encoding typical endotoxins. Under light and scanning electron microscope, typical crystal forms of various shapes were observed in the B. thuringiensis strains. A total of fourteen cry and cyt genes were identified in the strains analyzed. While the B. thuringiensis A4 strain had twelve cry and cyt genes in the genome, not all the genes were expressed, and only a few protein profiles were detected. The eight B. thuringiensis strains showed larvicidal activity (LC50 range: 1.4–28.5 µg/ml and LC95 range: 15.3-130.3 µg/ml). Interestingly, the B. thuringiensis A4 strain showed a high level of toxicity to mosquito larvae and adults, as detected by bioassays under controlled conditions. These new findings show that the novel B. thuringiensis A4 strain could be used as a favorable candidate source to control larvae and adult mosquitoes in a sustainable manner that is friendly to the environment.
Healthy behaviors among Non-Hispanic Black and Hispanic people affected by cancer during the post- treatment survivorship
Authors: SEVEN Memnun , Moraitis Ann Marie , Hammer Marilyn J. , Pearlman Jessica , Reid Allecia E. , Sturgeon Susan , Wenzel Jennifer 
Published: January 2023

Abstract
Purpose. This study aimed to understand the experiences of non-Hispanic black and Hispanic people affected by cancer in developing and maintaining positive health behaviors beyond a cancer diagnosis.
Methods. The data was collected in a mixed-method study through semi-structured interviews. A total of 29 Non-Hispanic Black (NHB) and Hispanic people affected by cancer were included between June- October 2022. Conventional content analysis was used to explore the variables of interest.
Results. The lived experiences of cancer survivors were narrated in three themes; the Impact of a cancer diagnosis on oneself, Facilitators and Barriers to health and health behaviors, and Utilization of available sources for health. Facilitators and barriers to health and health behaviors were further explored as biological (e.g., symptoms, comorbidities), behavioral (e.g., help-seeking behavior, sleep pattern), physical/built (e.g., available sources, healthcare, and community facilities, unsafe neighborhood), and sociocultural environment (e.g., income, transportation, knowledge, culture, upbringing, household and community composition, available social and family network), and healthcare system-related factors (e.g., insurance coverage, personal preferences, perceived discrimination and being dismissed, relationship with providers).
Conclusion. NHB and Hispanic people, specifically those living in disadvantaged neighborhoods with limited sources or where they feel discriminated and stereotyped, those with low socioeconomic status limiting income and transportation, and those with physical, social, or mental health problems, appeared to have challenges in prioritizing health behaviors and maintaining a healthy way of living.
Implications for Cancer Survivors. Biological, behavioral, and psychosocial determinants of health behaviors should be addressed through multilevel collaborations among different levels of partners.
Superior and ultrafast energy storage performance of relaxor-antiferroelectric HfO2-based supercapacitors
Authors: Shuai Wentao , Dai Jiyan , Xu Zihao , Tian Guo , Luo Chunlai , Li Ming , Tao Ruiqiang , Fan Zhen , Chen Deyang , Zhou Guofu , Lu Xubing , Liu Jun-Ming 
Published: January 2023

Abstract
Compared to electrochemical energy storage, dielectric thin film-based capacitors possess the advantages of higher voltage stability and higher break-down voltage as well as lower leakage current etc. Since HfO2 films are compatible to microelectronic process and its ferroelectricity is strategically important in memory device, the realization of their excellent energy storage comparable or better than those perovskite oxides will broaden their applications in microelectronic devices. In this work, to combine the merits of relaxor-ferroelectric and antiferroelectric, we experimentally demonstrate that a superparaelectric-like relaxor antiferroelectric behavior can be realized in the HfO2-based thin films and corresponding recoverable energy density over 100 J cm-3 can be achieved at efficiency higher than 80% as well as extremely high dielectric strength > 6 MV cm-1, compared to perovskite oxide materials. This is a record high energy density in all reported HfO2-based energy storage thin films, and beyond that, we also demonstrate their superfast charging/discharging as a capacitor. Targeting at high-speed supercapacitor applications in integrated circuit, HfO2-based dielectric may win the competition with perovskite oxides in terms of dielectric breakdown strength and charging/discharging speed etc. Our fundamental understanding of the physics behind also enriches the knowledge of materials science and dielectric physics.
REA: resource exergy analysis - Guidelines for evaluating and comparing energy systems
Authors: Jentsch Andrej 
Published: January 2023

Abstract

Using resource exergy analysis (REA) is key to ensure that climate targets can be reached in time.

The reason for this effect is wastefulness. Wastefulness, even in otherwise carbon neutral energy systems, increases the amount of energy required to cover the total energy demand.

If using carbon neutral energy systems, wastefulness leads to reduced availability of carbon neutral energy for the rest of the energy system. Since the energy demand is largely independent of energy production, wastefulness in an energy system in transition to carbon neutrality therefore increases overall fossil fuel use.

REA allows assessing wastefulness comprehensively and thus to obtain a scientific key indicator that is relevant to stopping climate change in addition to greenhouse gas emissions, namely resource exergy consumption.

This publication provides guidelines to the application of resource exergy analysis (REA) with a focus on energy systems evaluation.

REA is a well-tested application of exergy analysis to the field of technology comparison that can replace the less comprehensive primary energy analysis and reduce the risk of suboptimal decisions.
REGISTROS HERPETOLÓGICOS DEL PARQUE ECOLÓGICO DE LA MOLINA, LIMA, PERÚ.
Authors: Choy Pravatiner Manuel , Elías Piperis Roberto 
Published: January 2023

La presente investigación tuvo como objetivo evaluar y registrar las especies herpetológicas que habitan el Parque Ecológico de La Molina en Lima, Perú. Este parque es un área natural que forma parte del sistema de lomas de Villa María del Triunfo, no obstante ubicarse en el distrito de La Molina. Se registraron cinco especies de reptiles del Orden Squamata: dos serpientes, Bothrops pictus (Familia Viperidae) y Dipsas williamsi (Familia Colubridae); y tres saurios, Phyllodactylus lepidopygus (Familia Gekkonidae), Microlophus tigris y Microlophus sp. (Familia Tropiduridae). Todas las especies fueron previamente reportadas para el departamento de Lima, siendo M. tigris (n = 31/64) y P. lepidopygus (n = 29/64) las más abundantes. De las especies reportadas, dos han sido categorizadas por el Estado Peruano en situación Vulnerable (VU), B. pictus y P. lepidopygus, y una en Casi Amenazada (NT), M. tigris.
Natural Polymers as a Carrier for the Effective Delivery of Antineoplastic
Drugs
Authors: Patel Rajat , Kuwar Utkarsha , Dhote Nidhi , Alexander Amit , Nakhate Kartik , Jain Parag , Ajazuddin  
Published: January 2023

Abstract:
Cancer is a broad term for a set of disorders marked by the development of physically and
functionally changed cells that proliferate uncontrollably, infect neighboring tissues, and result in malignant
tumours, 'neoplasm'. Cancer remains a difficult disease to treat because of the significant adverse
effects and poor pharmacokinetic profile of antineoplastic drugs, despite advancements in our
understanding of the features and behavior of tumor cells in recent decades. In this series, the role of
natural polymers is prominent as a component of a novel delivery system of anticancer drugs. These natural
polymeric drug delivery systems (NPDDS) have many advantages over synthetic polymers like controlled
delivery, biodegradability, inexpensive, low toxicity profile, and easily obtainable. These polymers
further modify for the targeting of tumour cells. This review discusses and critically analyses the different
natural polymers, such as chitosan, cellulose, starch, albumin, dextran, fucoidan, gelatin, etc., in terms of
natural ingredient-based polymeric nanocarriers specifically for cancer therapy. It also describes benefits,
drawbacks, and opinions and provides insights about the efficacy of NPDDS as well as its future perspectives
and tabulated recent patents and cases under clinical trials exploited for cancer treatment.
Fatty Acid Synthase (FASN): A Patent Review Since 2016-Present
Authors: Singh Shailendra , Karthikeyan Chandrabose , Moorthy Narayana Subbiah Hari Narayana 
Published: January 2023

Abstract:
Fatty acid synthase (FASN), is a key metabolic enzyme involved in fatty acid biosynthesis
and is an essential target for multiple disease progressions like cancer, obesity, NAFLD, etc.
Aberrant expression of FASN is associated with deregulated energy metabolism of cells in these
diseases. This article provides a summary of the most recent developments in the discovery of
novel FASN inhibitors with potential therapeutic uses in cancer, obesity, and other metabolic disorders
such as nonalcoholic fatty liver disease from 2016 to the present. The recently published
patent applications and forthcoming clinical data of FASN inhibitors from both academia and the
pharma industries are also highlighted in this study. The implication of FASN in multiple diseases
has provided an impetus for developing novel inhibitors by both pharma companies and academia.
Critical analysis of the patent literature reveals the exploration of diverse molecular scaffolds to
identify potential FASN inhibitors that target the different catalytic domains of the enzyme. In
spite of these multifaceted efforts, only one molecule, TVB-2640, has reached phase II trials for
non-alcoholic steatohepatitis (NASH) and many malignancies. However, the combined efforts of
pharma companies to produce several FASN inhibitors might facilitate the clinical translation
of this unique class of inhibitors. Nevertheless, concerted efforts towards developing multiple
FASN inhibitors by pharma companies might facilitate the clinical translation of this novel class
of inhibitors.
Research on the Traditional and Low-Carbon Consumption Modes
Authors: Wang Ziwen , Chi Yuanying , Peng Rui , Yang Yang 
Published: January 2023

Abstract:
With the increasing severity of ecological and environmental problems, determining
how to develop a low-carbon economy has become the focus of scholarly research. As a necessary
component of a low-carbon economy, the low-carbon consumption mode plays an important role in
the sustainable development of all countries. In this paper, the existing research on the traditional
and low-carbon consumption modes is sorted out, the differences between the two consumption
modes are compared and analyzed, and relevant suggestions for the low-carbon transformation of
the consumption mode are put forward. To put forward the path from the traditional consumption
mode of residents to the low-carbon consumption mode. In order to minimize the harm to the ecological
environment, the low-carbon transformation of the consumption mode should be actively
carried out. The low-carbon transformation of the consumption mode of residents can be realized
from three perspectives, namely cultivating the low-carbon consumption awareness of residents,
establishing and perfecting the supervision system, and guiding the low-carbon production of enterprises.
Recent Patents on Red Jujube Harvester
Authors: Bao Yudong , Zhao Yafei , Zhang Jianlong 
Published: January 2023

Abstract:
As the demand for jujubes grows, so does the acreage of jujubes. However, the main
method of jujube picking is traditional manual picking, which is the most time-consuming and labor-
intensive in the production chain. Through the analysis and discussion of the patents on the jujube
harvester, some valuable conclusions are drawn to predict the research and development of the
jujube harvester in the future. An overview of various representative patents of the current jujube
harvester is provided in this paper. A large number of patents of jujube harvesting devices have been
summarized, the characteristics of these patents have been analyzed and compared, and the further
development trend of jujube harvesting machines has been developed. The research on the multifunction,
intelligence and versatility of the jujube harvester is helpful to solve the problems of low
efficiency, low quality, and poor versatility of the jujube harvester.
A Safe Place to Learn: Peer Research Qualitative Investigation of gameChange Virtual Reality Therapy
Authors: Bond Jessica , Kenny Alexandra , Pinfold Vanessa , Couperthwaite Lisa ,   The gameChange Lived Experience Advisory Panel, Kabir Thomas , Larkin Michael , Beckley Ariane , Rosebrock Laina , Lambe Sinéad , Freeman Daniel , Waite Felicity , Robotham Dan 
Published: January 2023

Background
Automated virtual reality (VR) therapy has the potential to substantially increase access to evidence-based psychological treatments. The results of a multicenter randomized controlled trial showed that gameChange VR cognitive therapy reduces the agoraphobic avoidance of people diagnosed with psychosis, especially for those with severe avoidance.

Objective
We set out to use a peer research approach to explore participants’ experiences with gameChange VR therapy. This in-depth experiential exploration of user experience may inform the implementation in clinical services and future VR therapy development.

Methods
Peer-led semistructured remote interviews were conducted with 20 people with a diagnosis of psychosis who had received gameChange as part of the clinical trial (ISRCTN17308399). Data were analyzed using interpretative phenomenological analysis and template analyses. A multiperspectival approach was taken to explore subgroups. Credibility checks were conducted with the study Lived Experience Advisory Panel.

Results
Participants reported the substantial impact of anxious avoidance on their lives before the VR intervention, leaving some of them housebound and isolated. Those who were struggling the most with agoraphobic avoidance expressed the most appreciation for, and gains from, the gameChange therapy. The VR scenarios provided “a place to practise.” Immersion within the VR scenarios triggered anxiety, yet participants were able to observe this and respond in different ways than usual. The “security of knowing the VR scenarios are not real” created a safe place to learn about fears. The “balance of safety and anxiety” could be calibrated to the individual. The new learning made in VR was “taken into the real world” through practice and distilling key messages with support from the delivery staff member.

Conclusions
Automated VR can provide a therapeutic simulation that allows people diagnosed with psychosis to learn and embed new ways of responding to the situations that challenge them. An important process in anxiety reduction is enabling the presentation of stimuli that induce the original anxious fears yet allow for learning of safety. In gameChange, the interaction of anxiety and safety could be calibrated to provide a safe place to learn about fears and build confidence. This navigation of therapeutic learning can be successfully managed by patients themselves in an automated therapy, with staff support, that provides users with personalized control. The clinical improvements for people with severe anxious avoidance, the positive experience of VR, and the maintenance of a sense of control are likely to facilitate implementation.
Canadian Pediatric Intensive Care Adaptations for Critically Ill Adults During the COVID-19 Pandemic: Survey Study
Authors: Parchomchuk Evan , Holt Tanya , Hansen Gregory 
Published: January 2023

Background
The COVID-19 pandemic overwhelmed Canadian hospitals with adult admissions. A large number of adult patients required critical care therapies, placing significant strain on hospital resources. In order to decompress adult intensive care units, pediatric intensive care units (PICUs) introduced adapted models of traditional care to lessen these burdens.

Objective
We aimed to evaluate how PICUs across Canada adapted care for the high volumes of critically ill adults.

Methods
A survey containing 40 questions was sent to the medical directors of 14 Canadian PICUs where English was the primary clinical language. The survey was designed to gain perspective on the various adaptations that PICUs instituted during the COVID-19 pandemic.

Results
Of the 13 PICUs that returned survey responses (response rate: 13/14, 93%), 10 (77%) participated in at least one adaptation to support the influx of admitted adults with COVID-19. The key challenges included disorganization, loss of autonomy, and compromised patient care. The significant advantages of these adaptations included a sense of learning and comradery.

Conclusions
Our study highlighted an unpreparedness in critical care surge capacity. During the COVID-19 pandemic, adaptations rapidly emerged in Canada that involved PICUs with adult care. In the future, preplanned adaptations for optimizing robust critical care services should be developed based on what has been learned from the COVID-19 pandemic.
A STUDY ON BACTERIOLOGICAL IDENTIFICATION OF SUB-GINGIVAL PLAQUES IN PERIODONTITIS PATIENTS
Authors: USHARANI PURIMITLA 
Published: January 2023

Objective: The current study's objectives were to isolate and characterize the periodontal pathogens from subgingival plaque obtained from patients with chronic periodontitis using conventional microbiological techniques.
Materials: In the Department of Microbiology at a Tertiary Care Teaching Hospital was where this study was carried out. Over the course of six months, from January to June 2019, samples were taken from subgingival pockets in patients with chronic periodontitis who visited the periodontology outpatient department at our institute of dental sciences. There were 21 cases in the research. For the purpose of preventing saliva contamination, tooth surfaces were dried using sterile gauze. Subgingival plaque samples were taken from the majority of diseased sites using a sterile periodontal Gracy curette, put in a test tube with fluid thioglycollate medium, and taken to the microbiology lab where they were processed right away using conventional microbiological procedures.
Results: E. coli grew in the majority of samples (9), followed by Pseudomonas species and Staphylococci in 7 samples. Only sample number 7 out of 21 showed no growth for Candida albicans; the others all exhibited development. Samples like Sample 1, 5, 6, 8, 10, 11, 12, 13, 15, 16, 17, 18, 19, and 20 produced isolates that were multidrug resistant.
Conclusion: Therefore, while developing a treatment plan for adult patients with periodontitis, the microbial diversity discovered in the current study should be taken into account. Variations in the quantities and species of cultivable bacteria have been found in investigations of periodontitis patients from different geographic regions, including developed and developing countries.