bluuebunny/crossref_metadata_2025_split huggingface dataset:
Avascular Midline Oropharyngeal Anatomy Allows for Expanded Indications for Trans-Oral Robotic Surgery in Pediatric Patients
Authors: Johnston Douglas , Maurrasse Sarah , Maddalozzo John 
Published: February 2023

Abstract
Introduction: Transoral robotic surgery (TORS) in children is in its infancy and indications have been primarily limited to lingual tonsillar hypertrophy and superficial mucosal lesions. However, the relatively avascular channel of the midline posterior tongue, vallecula, and posterior hyoid space provides a safe plane of dissection for deep lesions of the tongue and access to structures in the anterior neck. As robotic surgeons gain experience, application of this technology will continue to grow.
Methods: Retrospective case series
Results: We present seven patients who had either a primary (n = 3) or recurrent (n = 4) lingual thyroglossal duct cyst (TGDC) and underwent TORS excision. Four of the seven patients also underwent transoral resection of the central portion of the hyoid bone, while 3 had central hyoid resection during prior surgery. Two minor complications occurred with no evidence of lesion recurrence after mean follow up of 19.7 mo.
Discussion: The midline avascular channel of the tongue allows for relatively bloodless surgical access to pathologies of the midline base of tongue and anterior neck. Lingual thyroglossal duct cysts can safely be removed via TORS approaches with evidence of limited recurrence.
Conclusion: Robotic technology can provide safe and effective surgical alternatives for children with a variety of pathologies, and we aim to promote the widespread adoption of TORS in pediatric head and neck surgery by sharing our knowledge and clinical experience. Further study and publication are needed to establish safety and efficacy.
Assessing Lexical Skills to Determine Language Development of Urban Bi/multlingual Preschool Children
Authors: Siddiqui Amina Asif , Khalid Maha , Nazir Hina Fatima 
Published: February 2023

Abstract

Purpose This research determines the lexical development of preschool children in bi/multilingual Pakistani society, who are exposed to English (L2/L3) in playschool and their native language (L1) as well as Urdu (L1/L2) at home. The study aims to establish the lexical increment among the three age groups of children through conceptual scoring of their responses, on an indigenously designed tool for the assessment of vocabulary. Method This quantitative cross-sectional research recruited 100 (n) typical bi/multilingual children aged 2;0–4;11 years, by simple random sampling from mainstream playschools where the medium of instruction was English. They were individually screened through aScreener for Lexical Skills of Bi/multilinguals, which measured vocabulary development through 255 culturally appropriate pictures across twenty-one categories for their semantic and morphological skills, subsequently analyzing the data through the SPSS version 20. Results Bi/multilingual children from mainstream playschools named the pictures of theScreener for Lexical Skills of Bi/multilinguals, in English and Urdu predominantly, instead of their own native language. There was an incremental difference seen in the lexicon among the age groups, based on the number of pictures named by the children. The 2;0–2;11-year-olds named 40.7% of the pictures, while 3;0–3;11-year-olds named 49.02%, and 4;0–4;11-year-old children named 62.75% of the total pictures. Conclusion Children easily acquire multiple languages, in early childhood. The bi/multilingual children show an unequal increment in the vocabulary of each language, across the three age groups. Although all the children named some pictures in English, the increment in their Urdu vocabulary was greater than English.
Novel biologically active N-substituted benzimidazole derived Schiff bases: design, synthesis and biological evaluation
Authors: Beč Anja , Cindrić Maja , Persoons Leentje , Banjanac Mihailo , Radovanović Vedrana , Daelemans Dirk , Hranjec Marijana 
Published: February 2023

Abstract

Herein we present the design and synthesis of novel N-substituted benzimidazole derived Schiff bases, and the evaluation of their antiviral, antibacterial and antiproliferative activity. One of the goals was to study the impact on the biological activity of substituents placed at the N atom of benzimidazole nuclei as well as the type of substituents placed at the phenyl ring. The synthesized Schiff bases were evaluated for their in vitro antiviral activity against different viruses, antibiotic activity against a panel of bacterial strains and antiproliferative activity on several human cancer cell lines, thus enabling the study of structure − activity relationships. Some mild antiviral effects were noted, although at higher concentrations as compared to the included reference drugs. Additionally, some derivatives showed moderate antibacterial activity, with precursor 23 proving broadly active against most of the bacterial strains tested. Lastly, Schiff base 40, a 4-N,N-diethylamino-2-hydroxy substituted derivative bearing a phenyl ring at the N atom on benzimidazole nuclei, displayed strong antiproliferative activity against several cancer cell lines (IC50 1.1–4.4 µM). The strongest antitumoral effect was observed towards acute myeloid leukemia (HL-60).
Conversion of gravitational and electromagnetic waves without any external background field
Authors: Mishima Takashi , Tomizawa Shinya 
Published: February 2023

Abstract
Applying a simple harmonic map method to the cylindrically symmetric Einstein-Maxwell system, we obtain exact solutions representing strong nonlinear interaction between gravitational waves and electromagnetic waves in the case without any background field. As an interesting fact, we can show that with adjusted parameters the solution represents occurrences of large conversion phenomena in the intense region of fields near the cylindrically symmetric axis.
PACS numbers: 04.20.Jb, 04.30.-w
Immune-related transcripts, microbiota and vector competence differ in dengue-infected geographically distinct Aedes aegypti populations
Authors: Chen Tse-Yu , Bozic Jovana , Mathias Derrick , Smartt Chelsea 
Published: February 2023

Abstract
Background
Vector competence in Aedes aegypti is influenced by various factors and, by recognizing what affects virus and mosquito interactions, crucial new control methods can be developed.
Methods
Here we used three geographically distinct Ae. aegypti populations and compared their susceptibility to infection by dengue virus (DENV). To identify the population differences, we screened immune-related genes and microbiota which might contribute to the uniqueness in competency.
Results
Based on the results from the DENV competence study, we assigned a refractory population (Vilas do Atlântico), a susceptible population (Vero), and a susceptible but low transmission population (California). The immune-related transcripts were highly expressed in the California population but not in the refractory population. However, the Rel-1 gene upregulated after blood-feeding in the Vilas do Atlântico population suggesting involvement in non-viral responses, such as response to microbiota. The bacteria, fungi, and flaviviruses screening showed differences between populations and could be one of the factors that interfere with the vector competence.
Conclusions
All in all, we revealed the potential factors that might impact the virus and mosquito interaction, moreover, influencing the Aedes aegypti refractory phenotype.
Prediction of the Demand Response Behavior of Residential Consumers through a Bayesian Forecasting Method
Authors: Kaheh Zohreh , Arasteh Hamidreza 
Published: February 2023

Abstract
Demand-side resources have been recognized as a cost-effective approach for providing the required flexibility in power systems with high penetrations of renewable resources. Almost all existing demand response (DR) models are established based on the assumption that end-users are always rational and predictable agents with well-defined preferences. This assumption has resulted in apparently unaccountable divergence between modelled and observed results for DR approaches. However, due to the nature of the prompt responses of DR providers to DR signals, it is of paramount importance to consider the effect of impulsive decisions on providing the flexibility. This paper investigates the effects of impulsive decisions on the frequency of being unresponsive to DR signals and the collaboration rate in 5-minutes ahead DRX through a Bayesian Forecasting Method. The analyses have demonstrated considering the provided flexibility in similar days of week as explanatory variable in Bayesian structural time series can be helpful for the detection of impulsive behavior to attain more accurate DR behavior forecasting.
Posłanie Syna w ujęciu św. Tomasza z Akwinu
Authors: Ćwik Karolina 
Published: February 2023

Św. Tomasz z Akwinu pisząc o posłaniu Syna wpisuje je w szerszy kontekst nauki o wcieleniu. Posłanie rozumie on dwojako: jako posłanie niewidzialne oraz to widzialne.
O posłaniu niewidzialnym mówimy wtedy, gdy w duszy osoby będącej w łasce uświęcającej przebywa Bóg. Oddziałuje On na nasz intelekt – możemy poznać Boga oraz na naszą wolę – jesteśmy w stanie Go miłować. Akwinata podkreśla, że w Trójcy mówimy o jedności istoty, ale o odrębności Osób, dlatego też posłanie Syna różni się od posłania Ducha Świętego. Posłannictwo niewidzialne związane jest z życiem sakramentalnym, które prowadzi do pełnego umiłowania Boga i wzrastania człowieka w doskonałości.
Posłanie widzialne w ujęciu Akwinaty jest związane z wcieleniem Boga. Druga Osoba Trójcy Świętej została posłana, aby zbawić ludzi od grzechu, ukazując swoją nieograniczoną miłość do człowieka. Wcielenie ukazało, że świętość oraz życie wieczne powinno być celem człowieka, a wszystkie nasze myśli powinny być kierowane do Boga.
Ograniczenie własności nieruchomości naruszeniem godności właściciela
Authors: Karpacka Katarzyna 
Published: February 2023

Wychodząc z założenia, że godność człowieka stanowi aksjologiczną podstawę wszelkich praw i jest naczelną wartością konstytucyjnego katalogu praw i wolności, bytem niezaprzeczalnym,
niezbywalnym, opracowanie dowodzi, że w rzeczywistości, w świetle aktualnych przepisów, ustawodawca w różny sposób rozumie i chroni godność podmiotów prawa. Jest to szczególnie widoczne w relacjach lokatora i właściciela nieruchomości. Dysproporcja w tym zakresie powoduje, że prawo nie zawsze wyraża takie wartości jak sprawiedliwość, dobro i równość. Przepisy, zawężając granice prawa własności, wpływają na możliwość pełnego korzystania z rzeczy przez właściciela lokalu. Jednocześnie chronią lokatora tylko w określonych sytuacjach, przy użyciu minimalnych środków ochrony, bez realizacji kompleksowej polityki mieszkaniowej, która spełniłaby potrzeby mieszkaniowe osób, które nie są w stanie zaspokoić ich samodzielnie. Ten konflikt praw i godności utrzymuje się od wielu lat, dodatkowo pogłębiany kolejnymi nowelizacjami przepisów. W konsekwencji prowadzi to wielu bezprawnych sytuacji, które bezpośrednio naruszają godność obu stron.
Preliminary Study of the Distinctive Mechanism of Shenqi Compound in
Treating Rats with Type 2 Diabetes Mellitus by Comparing with Metformin
Authors: Fu Xiaoxu , Zhou Xiujuan , Liu Ya , Lei Yuanhong , Xie Hongyan , Leng Yulin , Gao Hong , Xie Chunguang 
Published: February 2023

Background:
In China, traditional Chinese medicine (TCM) has been used to treat type 2
diabetes mellitus (T2DM) for centuries.

Methods:
To investigate how the TCM ShenQi (SQC) formulation differs from metformin, four rat
groups, including control, model, T2DM rats treated using SQC (SQC group), and T2DM rats treated
using metformin (Met group), were constructed. The differentially expressed genes (DEGs) between
SQC and metformin groups were screened, and the co-expression modules of the DEGs were constructed
based on the weighted correlation network analysis (WGCNA) method. The correlation between
modules and metabolic pathways was also calculated. The potential gene targets of SQC were obtained
via the TCM systems pharmacology analysis.

Results:
A total of 962 DEGs between SQC and Met groups were screened, and these DEGs were significantly
enriched in various functions, such as sensory perception of the chemical stimulus, NADH
dehydrogenase (ubiquinone) activity, and positive regulation of the fatty acid metabolic process. In
addition, seven co-expression modules were constructed after the redundancy-reduced process. Four of
these modules involved specific activated or inhibited metabolic pathways. Moreover, 334 effective
ingredients of SQC herbs were collected, and four genes (RNASE1 (ribonuclease A family member 1,
pancreatic), ADRB1 (adrenoceptor beta 1), PPIF (peptidylprolyl isomerase F), and ALDH1B1 (aldehyde
dehydrogenase 1 family member B1)) were identified as potential targets of SQC.

Conclusion:
Comparing SQC with metformin to treat T2DM rats revealed several potential gene targets.
These genes provide clues for elucidating the therapeutic mechanisms of SQC.
Evolution of Probiotic Usage in the Global Food Industry: A Comprehensive
Review
Authors: Jayasekara Gammadde Hewa Hishara , Jayasinghe Madhura , Jayasinghe Jagath 
Published: February 2023

Abstract:
Food fermentation is one of the oldest food preservation and processing methods that
uses live microorganisms and dates back thousands of years in human civilization. From those
days, human society has used them without knowing the true value of these live microorganisms.
But later, they understood the beneficial health effects of some organisms used in fermentation.
Later they were named probiotics. With the advancement of science, the taxonomic and morphological
details of probiotic bacteria and fungi were identified. In the early stage of human civilization,
probiotics were used only for the preservation of excess food stuff, but now they have
been used for many other aspects. Encapsulated probiotics and dried probiotics enhance the benefits
of probiotics while reducing the major drawback of survivability in harsh conditions. Genetically
engineered probiotics organisms open new avenues in the nutraceutical industry, having
maximum benefits to the host. In modern medicine, probiotic functional foods have been used as
nutraceuticals for multi-drug resisting organisms and as transport vectors. In the near future, Super
probiotic organisms will be the new step in human civilization in terms of food and therapeutic
medicine.
Anthropomorphic Carotid Artery Phantom for Ultrasound Flow and
Vessel Wall Elastography Imaging
Authors: Almutairi Fahad F. , Alyami Jaber H. 
Published: February 2023

Objective:
Shear wave elastography imaging (SWE) is a non-invasive US technique that has
been developed to provide quantitative information about tissue elasticity. This technique might be
useful in the identification of vascular risk factors. Arterial wall thickness and inner diameter vary with
age and disease, which may impact shear wave propagation. The effect of arterial geometry on SWE
has not yet been thoroughly investigated. Therefore, this study aimed to investigate the impact of different
wall thickness, pulsation and imaging planes on YM estimates, to gain more information about
the source of variability associated with SWE.

Methods:
Poly(vinyl alcohol) cryogel (PVA-c) fabrication has been used for phantom design and construction.
The agar-based TMM was used to surround the tubes. The inlet and outlet of the phantom
were connected to a programmable gear pump using c-flex tubing to form a closed loop. Image J profiling
was used to clarify the anomalies further detected using SWE.

Results:
The 4 F/T cycle vessel phantom has shown less YM variability than in the 6 F/T cycle. YM
ranged from 8 kPa for a 1 mm thickness tube to 53 kPa for the thickest 6 mm wall thickness for the
softer 4 F/T cycle tube. Vessel phantoms embedded in TMM show higher variability than vessel phantoms
submerged in water. YM ranged from 32 kPa for a 1 mm thickness tube to 117 kPa for the thickest
6 mm wall thickness for the softer 4 F/T cycle tube.

Conclusion:
SWE variability in measurements was higher in phantoms embedded in TMM compared
to those submerged in water. It is recommended that combine the transverse and longitudinal imaging
planes to provide a better understanding of disease over the full vessel circumference.
Development and Implementation of the Hdc.DrApp.la and SIMDA Programs to Reduce Polypharmacy and Drug-drug Interactions in Patients Hospitalized in Internal Medicine
Authors: Barcia Ricardo Enrique , Keller Guillermo Alberto , Azzato Francisco , Diez Roberto Alejandro , Sielecki Mathias , Kleine Ricardo Samson , Lescano Juan Alberto , Giunti Guido 
Published: February 2023

Objectives:We evaluated polypharmacy and possible drug-drug interactions (p-DDIs) in hospitalized patients before and after using the SIMDA Computerized Medical Decision Support System (CMDSS).Materials and Methods:We included the prescriptions of ≥ 18 years hospitalized patients in the internal medicine department. We developed and implemented the Hdc.DrApp Physician Order Entry System and the CMDSS SIMDA, which detects p-DDIs and signals dosage adjustment based on renal function. To evaluate the impact of the CMDSS, we made a comparison Before (Survey) / After (Intervention): Survey between Oct/22/2019, and Mar/21/2020, and Intervention between Apr/4/2020 and Sep/3/2020. We analyze prescriptions from the first day and after the first day. We compared the number of drugs, polypharmacy (≥ 5 drugs), excessive polypharmacy (≥ 10 drugs), and p-DDIs. We evaluated differences with the X2 test, Yates correction, Fisher's exact test, ANOVA, and post hoc tests according to their characteristics.Results:We evaluated 2,834 admissions: Survey 1,211 and Intervention 1,623. The number of drugs per patient was 6.02 (± 3.20) in Survey and 5.17 (± 3.22) in Intervention (p < 0.001) on the first day and 9.68 (± 5.60) in Survey and 7.22 (± 4.93) in Intervention (p < 0.001) throughout the hospitalization. Polypharmacy was present in 64% of the Survey and 53% of Interventions (RR: 0.83 (0.78-0.88); and excessive polypharmacy in 14% of the Survey and 10% of Intervention (RR: 0.73, 0.60-0.90). The frequency of total p-DDIs was 1.91/patient (± 4.11) in Survey and 0.35 (± 0.81) in the Intervention (p < 0.001).Conclusion:We developed and implemented the Hdc.DrApp and SIMDA systems that were easy to use and allowed us to quantify and reduce polypharmacy and p-DDIs.
A DE AÚ B DE BERIMBAU C DE CAPOEIRA: TRAJETÓRIA ESCOLAR DE UMA MULHER NEGRA
Authors: Ferreira Nunes Míghian Danae , Da Silva Ariana Lais 
Published: February 2023

O presente artigo versa sobre a trajetória escolar de uma professora de capoeira, moradora de um município localizado no Recôncavo Baiano. Em março de 2020, ouvimos a trajetória escolar de Fortaleza, uma mulher negra. Este texto está dividido em três seções: na primeira, tratamos dos percursos metodológicos, que contou com a utilização de abordagem qualitativa e entrevista semiestruturada; na segunda, tratamos dos referenciais teóricos apresentando os conceitos fundamentais para a análise; na terceira, temos duas subseções em que analisamos a trajetória de vida da entrevistada lançando mão dos aportes teóricos. Ao longo do texto surgiram aspectos que relacionam sua trajetória escolar com as fases de sua trajetória na capoeira, fazendo-nos perceber que sua vivência em ambiente escolar foi diferenciada, simultaneamente, por sua inserção e empenho na prática desde a década de 1990, bem como, pelos impactos da Constituição do Estado da Bahia de 1989, na história da educação da população negra baiana.
Perspektif Maslahah Mursalah Terhadap Pernikahan Suami Pada Masa Iddah Istri Pasca Surat Edaran DirjJen Bimas Islam Nomor: P-005/DJ.III/Hk.00.7/10/2021 Tentang Pernikahan Dalam Masa Iddah Istri
Authors: Jayusman Jayusman , Efrinaldi Efrinaldi , Putra Andi Eka , Bunyamin Mahmudin , Faizi Habib Nur 
Published: February 2023

Penelitian ini menganalisis permasalahan pengimplementasian Surat Edaran Direktorat Jenderal Bimbingan Masyarakat Islam Nomor: P-005/DJ.III/Hk.00.7/10/2021 Tentang Pernikahan Dalam Masa Iddah Istri Di Kantor Urusan Agama Kecamatan Seputih Mataram. Pada praktiknya, terdapat pernikahan mantan suami sebelum habisnya masa iddah istri. Fokus penelitian ini adalah bagaimanakah tinjauan maslahah mursalah terhadap Implementasi Surat Edaran Direktorat Jenderal Bimbingan Masyarakat Islam Nomor: P-005/DJ.III/Hk.00.7/10/2021 Tentang Pernikahan Dalam Masa Iddah Istri Di Kantor Urusan Agama Kecamatan Seputih Mataram. Kesimpulan penelitian ini bahwa Surat Edaran dari Direktorat Jenderal Bimbingan Masyarakat Islam Nomor: P-005/DJ.III/Hk.00.7/10/2021 tidak dilaksanakan dengan baik di KUA Kecamatan Seputih Mataram sehingga dikhawatirkan akan mendatangkan kemudaratan pada pernikahan mantan suami tersebut. Hal ini disebabkan menikah secara tergesa-gesa pada masa iddah mantan istri mengabaikan kesempatan berfikir secara jernih untuk membangun kembali rumah tangga yang baru pasca perceraian dari pernikahan sebelumnya.
Profiling students at risk of dropout at a university in South Africa
Authors: Ntema Ratoeba Piet 
Published: February 2023

Background: Higher education authorities continue to be concerned about dropout rates among university students. Dropping out affects cost efficiency and tarnishes the reputation of the institution. As a result, profiling at risk student of dropout is crucial.
Purpose: To build a profile of students at risk of dropout using administrative university data.
Methods: The researcher employed a data mining technique in which predictors were chosen based on their weight of evidence (WOE) and information value (IV). The chosen predictors were then used to build a profile of students at risk of dropout.
Findings: According to the findings, the student is at risk if was born in the years 1931 to 1967 or 1994 to 2001; fails more than four modules in a year with a participation average mark of 43percent or less; and has joined the university in the second academic year.
Conclusions: This study concludes that matric scores had no bearing on the chance of a student dropping out for the cohorts of students who attended the institution between 2008 and 2018. However, the variables number of modules failed, participation average marks, entry level and year of birth had a bearing for building a profile for the students at risk of dropout for the cohorts of students who attended the institution between 2008 and 2018.