bluuebunny/crossref_metadata_2025_split huggingface dataset:
Handling heat‐stable salts in post‐combustion CO2 capture: A detailed survey
Authors: Emori Wilfred , Udoh Inime I. , Ekerenam Okpo O. , Ikeuba Alexander I. , Etim IniIbehe N. , Njoku Chigoziri N. , Daniel Enobong F. , Njoku Demian I. , Uzoma Paul C. , Kolawole Sharafadeen K. , Olanrele Olajire S. 
Published: September 2023

AbstractThe generation of heat‐stable salts (HSSs) in alkanolamine solutions for CO2 capture processes, which is adapted for power plant technologies, exists irrespective of the class of amine solution used for the capture process. Their presence do not only trigger decrements in the CO2 absorption capacities of the solvents and contribute to further alkanolamine degradation, but also result in foaming and loss of solvents, which impacts system economics and threatens the environment. HSSs also promote the corrosiveness of the metallic structures of capture systems by lowering the pH and increasing the conductivity of the absorbent solutions. Overall, these effects substantially subvert the reliability and integrity of CO2 capture units. This survey affords sufficient background on the existence of HSSs by unraveling the flow process in a typical alkanolamine‐based CO2 capture unit with respect to their formation points and potential threats. Furthermore, the major HSSs removal and alkanolamine reclamation methodologies (electrodialysis, distillation, ion exchange, electromagnetic separation, and solvent extraction) were comprehensively explored. We believe that this review paper will benefit researchers across disciplines as we continue to explore new and complex solvent formulations to minimize the cost of CO2 capture while maximizing efficiency. © 2023 Society of Chemical Industry and John Wiley & Sons, Ltd.
Rural postsecondary encouragement through a land grant university county extension office
Authors: Musoba Glenda Droogsma , Lopez Juan 
Published: September 2023

AbstractRural students graduate from high school at higher rates but go to college at lower rate than their urban and suburban peers. To take on the educational attainment challenge for rural students, we need to know more about postsecondary encouragement programs. This study examined a pilot postsecondary encouragement program in 11 rural high schools with two questions: How do high school counselors support students’ plans for life after high school through a land‐grant outreach program? How is a university outreach program utilized in these schools? This qualitative case study used 17 individual interviews with school counselors and county extension agents. According to school counselors, the postsecondary encouragement program increased financial aid applications and student interest in college going. County extension agents were a trusted bridge between the program and the local high schools. Tracking student milestones helped school counselors serve all students, and program experts provided workshops for students and parents. Campus visits helped students visualize themselves as college students, yet financial concerns dominated the students’ college choices.Practical Takeaways
Postsecondary encouragement through information from experts combined with local support can be a cost‐effective intervention to increase rural students’ college going.
Counselors tracking all students for college and career readiness milestones ensure all students are given the message that they are college material, a predictor of enrollment.
Counselors and students lack clear information about costs and financial aid availability, but these are important to rural families’ decisions.
Local county extension agents can serve as the bridge between the rural student population and the 4‐year universities. Extension agents and school counselors gave credibility to outside experts.
Impact of propofol versus sevoflurane anesthesia on molecular subtypes and immune checkpoints of glioma during surgery
Authors: Cen Shenghua , Yang Guocai , Bao Hongyan , Yu Ze , Liang Lei 
Published: September 2023

AbstractBackgroundSevoflurane and propofol are two popular anesthetics used during glioblastoma (GBM) surgery. This investigation compared the molecular subtypes and immune checkpoints of cancer cells following GBM surgery under sevoflurane and propofol anesthesia.MethodThe expression profile data and clinical information of glioma samples of different grades were downloaded from The Cancer Genome Atlas database. Weighted gene coexpression network analysis was used to identify hub modules and key genes related to glioma grades (G2 and G3). The GEO database (GSE179004) was used to retrieve glioma surgical specimens with different anesthetic gene expression profiles. The differential expression of immune checkpoint genes under various anesthetic settings was examined using the R‐ggplot2.ResultsCompared to sevoflurane, propofol significantly downregulated SERPINI1 and CAMK2A expression. These are also important factors in glioma grading. Simultaneously, SERPINI1 and CAMK2A were also significantly related to the prognosis of GBM and lower‐grade glioma patients and acted as potential tumor suppressors. In addition, propofol increases the expression of the immune checkpoint molecule, PD‐L1.ConclusionsOur study revealed that sevoflurane can more effectively prevent the development of glioma after surgery than propofol, and SERPINI1 can be used as a new independent prognostic factor for glioma.
Identifying suicide documentation in clinical notes through zero‐shot learning
Authors: Workman Terri Elizabeth , Goulet Joseph L. , Brandt Cynthia A. , Warren Allison R. , Eleazer Jacob , Skanderson Melissa , Lindemann Luke , Blosnich John R. , O'Leary John , Zeng‐Treitler Qing 
Published: September 2023

AbstractBackground and AimsIn deep learning, a major difficulty in identifying suicidality and its risk factors in clinical notes is the lack of training samples given the small number of true positive instances among the number of patients screened. This paper describes a novel methodology that identifies suicidality in clinical notes by addressing this data sparsity issue through zero‐shot learning. Our general aim was to develop a tool that leveraged zero‐shot learning to effectively identify suicidality documentation in all types of clinical notes.MethodsUS Veterans Affairs clinical notes served as data. The training data set label was determined using diagnostic codes of suicide attempt and self‐harm. We used a base string associated with the target label of suicidality to provide auxiliary information by narrowing the positive training cases to those containing the base string. We trained a deep neural network by mapping the training documents’ contents to a semantic space. For comparison, we trained another deep neural network using the identical training data set labels, and bag‐of‐words features.ResultsThe zero‐shot learning model outperformed the baseline model in terms of area under the curve, sensitivity, specificity, and positive predictive value at multiple probability thresholds. In applying a 0.90 probability threshold, the methodology identified notes documenting suicidality but not associated with a relevant ICD‐10‐CM code, with 94% accuracy.ConclusionThis method can effectively identify suicidality without manual annotation.
Maternal diabetes following gestational diabetes: Does multiple gestation multiply the risk?
Authors: Wainstock Tamar , Yoles Israel , Sergienko Ruslan , Sheiner Eyal 
Published: September 2023

AbstractObjectiveTo assess whether the risk for future diabetes is higher among women diagnosed with gestational diabetes (GD) during twin versus singleton gestations.MethodA retrospective cohort study was performed including all women who delivered at a tertiary medical center between the years 1991 and 2021 and had at least one GD diagnosis. The first GD diagnosis per women was defined as the index pregnancy. Women diagnosed with GD during multiple gestations were compared with women diagnosed with GD during singleton gestations. The outcomes included first hemoglobin A1C (Hba1C) level > 6.4 mg/dL post partum, and the highest level measured during the follow‐up period of up to 30 years. Multivariable logistic and Cox proportional analysis were used to compare the risk between the two groups while adjusting for confounding variables.ResultsThe current study included 13 770 mothers, with 458 patients (3.3%) diagnosed with GD during twin gestations and 13 312 (96.7%) during singleton gestations. The mean follow‐up was 12.25 ± 9.3 years. Mothers of both groups did not differ in age at index pregnancy; however, mothers of twins were more likely to conceive following fertility treatments. Incidence of diabetes and prediabetes (defined as Hba1C > 6.4 and >5.7, respectively) were lower among the twin‐gestation group, both during the 6‐month postpartum period (for diabetes: 15.5% vs 22.1%; odds ratio [OR], 0.65 [95% confidence interval (CI), 0.46–0.91]) and during the long‐term follow‐up (for diabetes: 31.8% vs 40.7%; OR, 0.68 [95% CI, 0.52–0.88]). These results remained significant in the multivariable analysis, while accounting for age, ethnicity, and fertility treatments.ConclusionGD diagnosis during multiple versus singleton gestations is associated with a lower risk for future diabetes.
Biosynthesis and characterization of selenium nanoparticles from Andrographis alata: Assessment of their potential antimicrobial, antidiabetic, anti‐Alzheimer's and wound healing properties
Authors: Gong Wei , Li Xiaoyun 
Published: September 2023

AbstractRecently, there has been a lot of focus on the environmentally friendly, specifically plant‐based, synthesis of nanoparticles. The extract of leaves from Andrographis alata (A. alata) was used in the current work as a reducing agent to create selenium nanoparticles (SeNPs), which will be used in biological applications (antibacterial, antioxidant and antidiabetic, anti‐Alzheimer's and wound healing properties). As part of detailed characterization, the UV–Vis spectra showed an absorption peak at 274 nm with a size in the range of 55–75 nm were shown in morphological investigations using EDS, DLS and SEM analysis to have crystalline spherical‐shaped structures. Against several harmful bacterial strains, SeNPs demonstrated a remarkable antibacterial effectiveness. The minimum inhibitory concentration (MIC) of synthesized SeNPs completely prevented the development of various pathogens. Furthermore, bio‐reduced SeNPs showed high cholinesterase inhibition efficacy and good antipotential Alzheimer's. According to the current research, treatment with biosynthesized SeNPs stimulates faster wound healing in NIH3T3 murine fibroblast cell lines without cytotoxicity. Different in vitro biological experiments also showed that, when compared with the extract of A. alata, bio‐reduced SeNPs had considerable antibacterial, antioxidant effects, antidiabetic, anti‐Alzheimer's and wound healing. In general, the findings demonstrate the efficacy and prospective therapeutic uses of SeNPs.
Facile synthesis of neodymium vanadate nanoribbons and its application to highly efficient determination of cadmium ions
Authors: Cong Qianmin , Wang Xiaoyu , Feng Chenxu , Sun Zizhan , Cai Chenxi , Fan Chuangang , Pei Lizhai 
Published: September 2023

AbstractBACKGROUNDCadmium ions may be discarded to the environment with living organisms from fossil fuel combustion, phosphate fertilizer and battery industries. It is urgent and essential to develop a sensitive and rapid method for monitoring Cd2+ level in aquatic environments and biological systems. Neodymium vanadate possesses good catalytic performance for the electrocatalysis of heavy metal ions. Single crystalline Nd vanadate nanoribbons were obtained by a facile approach and used as electrode materials for electrochemical detection of Cd2+.RESULTSThe Nd nanoribbons with tetragonal NdVO4 phase possess length, width and thickness of longer than 10 μm, 200 nm to 1.5 μm and 50 nm, respectively. Nd vanadate nanoribbons can serve as a good electron transfer interface. An anodic peak is located at +0.56 V at the Nd vanadate nanoribbon‐modified electrode in 0.1 mol L−1 KCl electrolyte containing 1 mmol L−1 Cd2+ by square wave voltammetry technique. The Nd vanadate nanoribbon‐modified electrode exhibits a linear range of 0.01–1000 μmol L−1 and a detection limit of 0.29 nmol L−1, with good stability, reproducibility and selectivity for Cd2+ detection.CONCLUSIONThe optimal measurement conditions including the pH value of the KCl solution, deposition time, deposition potential and standing time, which are pH 1, 180 s, −1.0 V and 60 s, respectively. The Nd vanadate nanoribbon‐modified electrode shows great application potential for detecting heavy metal ions in liquid environments. © 2023 Society of Chemical Industry.
Daratumumab‐based induction and autologous transplantation in concomitant multiple myeloma and chronic myeloid leukemia
Authors: Liberatore Carmine , Fioritoni Francesca , Natale Annalisa , Montanaro Guido , La Barba Gaetano , Passeri Cecilia , Iuliani Ornella , Fabi Bianca , Baldoni Stefano , Fantasia Donatella , Calabrese Giuseppe , Accorsi Patrizia , Santarone Stella , Pulini Stefano , Di Ianni Mauro 
Published: September 2023

AbstractThe coexistence of chronic myeloid leukemia (CML) and multiple myeloma (MM) is a rare clinical condition. By means of FISH and molecular analysis on both sorted CD138 plasma cells and cryopreserved CD34 stem cells, a distinct clonal origin of the hematological malignancies was demonstrated in our case. We report on the first patient diagnosed with CML and MM treated with daratumumab, bortezomib, thalidomide, and dexamethasone (Dara‐VTd) induction, stem‐cell collection, and autologous stem cell transplantation (ASCT). The co‐administration of Dara‐VTd and imatinib proved feasible and highly effective in the management of both CML and MM. Despite concerns with stem cell mobilization and collection in patients exposed to daratumumab, in our experience the use of higher cyclophosphamide dose 4 g/m2 together with plerixafor granted optimal stem cell mobilization and collection, irrespective of daratumumab, concomitant myeloid neoplasm, and imatinib. Moreover, ASCT was easily performed with a rapid hematological reconstitution.
Patients with primary carnitine deficiency treated with L‐carnitine are alive and doing well—A 10‐year follow‐up in the Faroe Islands
Authors: Abrahamsen Rannvá K. , Lund Allan M. , Rasmussen Jan 
Published: September 2023

AbstractPrimary carnitine deficiency (PCD) can be lethal. Carnitine is essential for the transfer of long‐chain fatty acids across the inner mitochondrial membrane for β‐oxidation. The reported prevalence of PCD in the Faroe Islands of 1:300 is the highest in the world. The Faroese PCD patient cohort has been closely monitored and we now report results from a 10‐year follow‐up study of 139 PCD patients. Four patients have died of natural causes since diagnosis. There were no signs of cardiac complications related to PCD. 70.5% reported an effect of L‐carnitine treatment. 33.7% reported current symptoms with fatigue and low stamina being the most common. 65.1% had experienced side effects during L‐carnitine treatment. Most common side effects were fish odor, abdominal pain, and diarrhea. The overall mean L‐carnitine dosage was 66.3 mg/kg/day. Free p‐carnitine was similar between male and female patients on L‐carnitine—18.6 and 18.8 μmol/L, respectively. L‐carnitine supplementation seems to be a safe and effective treatment when suffering from PCD. PCD patients in the Faroe Islands are alive and doing well more than 10 years after diagnosis.
Spectroscopic, quantum chemical investigation and molecular docking studies on N‐(2‐benzoylamino) phenyl benzamide: A novel SARS‐CoV‐2 drug
Authors: Pushpam S. , Christopher Jeyaseelan S. , Jesintha Rani R. , Hussain Shamima , Milton Franklin Benial A. 
Published: September 2023

AbstractThe present work describes the structural and spectral properties of N‐(2‐benzoylamino) phenyl benzamide (NBPB). The geometrical parameters of NBPB molecule such as bond lengths, bond angles and dihedral angles are calculated and compared with experimental values. The assigned vibrational wave numbers are in good agreement with the experimental FTIR and FT Raman spectra. The vibrational frequency of C=O stretching was downshifted to a lower wave number (red shift) due to mesomeric effect. The UV–Vis spectrum of the title compound was simulated and validated experimentally. The energy gap and charge transfer interaction of the title molecule were studied using frontier molecular orbital analysis. The electrophilic and nucleophilic reactivity sites of NBPB were investigated through the analysis of the molecular electrostatic potential surface and the Fukui function. An assessment of the intramolecular stabilization interactions of the molecule was performed using natural bond orbital analysis. The drug‐likeness parameter was calculated. To investigate the inhibitory potential of the molecule, molecular docking analysis was conducted against SARS‐CoV‐2 proteins, revealing its capability to serve as a novel inhibitor against SARS‐CoV‐2. The high binding affinity of NBPB molecule was due to the presence of hydrogen bonds along with different hydrophobic interactions between the drug and the SARS‐CoV‐2 protein receptor. Hence, the title molecule is identified to be a potential candidate for SARS‐CoV‐2.
Metarhizium pingshaense photolyase expression and virulence to Rhipicephalus microplus after UV‐B exposure
Authors: de Lima Pamella Pryscila de A. B. M. , Fiorotti Jessica , Paulino Patrícia G. , Corval Amanda R. da C. , Mesquita Emily , Corrêa Thaís A. , Lopes Adriani da S. C. , Oliveira Rafael José V. de , Santos Huarrisson A. , Bittencourt Vânia R. E. P. , Angelo Isabele da C. , Golo Patrícia S. 
Published: September 2023

AbstractThe current study examined the impact of ultraviolet (UV)‐B radiation in Metarhizium pingshaense blastospores' photolyase expression and their virulence against Rhipicephalus microplus. Blastospores were exposed to UV under laboratory and field conditions. Ticks were treated topically with fungal suspension and exposed to UV‐B in the laboratory for three consecutive days. The expression of cyclobutane pyrimidine dimmers (CPDs)‐photolyase gene maphr1‐2 in blastospores after UV exposure followed by white light exposure was accessed after 0, 8, 12, 24, 36, and 48 h. Average relative germination of blastospores 24 h after in vitro UV exposure was 8.4% lower than 48 h. Despite this, the relative germination of blastospores exposed to UV in the field 18 h (95.7 ± 0.3%) and 28 h (97.3 ± 0.8%) after exposure were not different (p > 0.05). Ticks treated with fungus and not exposed to UV exhibited 0% survival 10 days after the treatment, while fungus‐treated ticks exposed to UV exhibited 50 ± 11.2% survival. Expression levels of maphr1‐2 8, 12, and 24 h after UV‐B exposure were not different from time zero. Maphr1‐2 expression peak in M. pingshaense blastospores occurred 36 h after UV‐B exposure, in the proposed conditions and times analyzed, suggesting repair mechanisms other than CPD‐mediated‐photoreactivation might be leading blastospores' germination from 0 to 24 h.
Selection of yeast strains in naturally fermented cured meat as promising starter cultures for fermented cured beef, a traditional fermented meat product of northern China
Authors: Zhang Qiuhui , Shen Jialong , Meng Gaoge , Wang Han , Liu Chang , Zhu Chaozhi , Zhao Gaiming , Tong Lin 
Published: September 2023

AbstractBACKGROUNDFermented meat products are meat products with a unique flavor, color, and texture as well as an extended shelf life under natural or artificially controlled conditions. Microorganisms or enzymes are used to ferment the raw meat so that it undergoes a series of biochemical and physical changes. Common fermentation strains are lactic acid bacteria, yeasts, staphylococci, molds, and so forth. Studies on the inhibitory effect of yeast fermentation strain on N‐nitrosamines in fermented meat products have not been reported. Two excellent yeast starters were identified to solve the problem of nitrosamines in fermented meat products.RESULTSMeyerozyma guilliermondii and Debaryomyces hansenii led to weak acid production, strong resistance to NaCl and NaNO2, and high tolerance to low acidic conditions. The inoculated fermented beef exhibited decreased lightness, moisture content, water activity, pH, protein content, nitrite content, and N‐nitrosamine content in comparison with the control group fermented bacon. M. guilliermondii had a better effect, reducing pH from 5.69 to 5.41, protein content from 254.24 to 221.92 g·kg−1, nitrite content from 28.61 to 25.33 mg·kg−1 and N‐nitrosamine by 18.97%, and giving the fermented beef the desired meat color, mouthfeel, odor, taste, and tissue quality.CONCLUSIONIn this study, two strains of yeast fermenters that can degrade N‐nitrosamine precursors were identified, which to some extent solves the problem of the high risk of generating nitrosamines such as N‐nitrosodiethylamine (NDEA) by processing fermented meat products with nitrites as precursors. These two strains are likely to be used as starter cultures for fermented meat products. © 2023 Society of Chemical Industry.
Determination of ticagrelol in rat plasma and tablets by micellar electrokinetic chromatography coupled with large volume sample stacking: Application to a pharmacokinetic study
Authors: Zayed Sahar , Belal Fathalla 
Published: September 2023

A method using micellar electrokinetic chromatography coupled with large‐volume sample stacking for the determination of ticagrelol was developed and validated. The analysis was performed in a fused silica capillary (41.5 cm effective length, 50 μm diameter) with ultraviolet detection at 195 nm. The background electrolytes were 30 mM phosphate buffer of pH 3.0 with 120 mM sodium dodecylsulfate and 10 % (v/v) acetonitrile (120 s X 50 mbar; 20°C; ‐18 kV) and 30 mM borate buffer of pH 8.5 with 75 mM sodium dodecylsulfate (120 s X 50 mbar; 20°C; 25 kV); under acidic and alkaline conditions, respectively. The method was found to be reliable with respect to specificity, linearity of the calibration line (R2 > 0.99), repeatability (relative standard deviation 2.56%–3.34%), and accuracy (recovery in the range 101.21%–102.67%). The limits of detection and quantitation were 0.032, 0.071, and 0.087, 0.188 μg/mL, respectively. The method was successfully applied for the determination of ticagrelol concentrations in rat plasma and tablets with good recoveries and reproducibility. The presented method proved to be suitable for monitoring ticagrelor in rat plasma.