bluuebunny/crossref_metadata_2025_split huggingface dataset:
Two-level optimal scheduling strategy of demand response-based microgrids based on renewable energy forecasting
Authors: Sun Sizhou , Wang Yu , Wang Hongtao , Meng Ying , Liu Shilin 
Published: July 2023

Abstract
Considering the influences caused by the uncertainty of renewable energy generation (REG) and load on the stable operation of microgrid (MG), a two-level optimal scheduling strategy, including upper-level model and lower-level model, of demand response-based MGs using improved deep reinforcement learning (DRL) is proposed in this study. In the two-level optimal scheduling strategy, energy optimal set points of different distributed generators in the upper-level model are optimized with the objective of the minimal operational cost of the MG, demand response based on dynamic electricity pricing mechanisms is employed to minimize the electricity cost of the consumers in the lower-level model, and the opportunity constraint is transformed into a mixed-integer linear programming to simplify the solution of the optimization scheduling model. To deal with the uncertainty of the renewable energy and load, a freshness priority experience replay deep reinforcement learning (FPER-DRL) is developed to deploy the DRL prediction model for prediction of REG and load power. Finally, the experimental results illustrate that compared with traditional scheduling models based on probability density functions, the proposed method in this paper has more accurate prediction results for load power and renewable energy output, the economic benefits of MG and power users have been also improved.
19 F MRI signal-enhancement by photo-chemically induced dynamic nuclear polarization enables spatially-resolved detection of sub-nmol amount of the antiviral drug favipiravir
Authors: Bernarding Johannes , Bruns Christian , Prediger Isabel , Mützel Markus , Plaumann Markus Plaumann 
Published: July 2023

Abstract
In biological tissues, 19F magnetic resonance (MR) enables the non-invasive, background-free detection of 19F-containing biomarkers. However, the signal-to-noise ratio (SNR) is usually low because biomarkers are typically present at low concentrations. Measurements at low magnetic fields further reduce the SNR. We therefore applied LED-based photo-chemically induced dynamic nuclear polarization (photo-CIDNP) to amplify the 19F signal at 0.6 T. For the first time, 19F MR imaging (MRI) and spectroscopy (MRS) of a fully biocompatible model system containing the antiviral drug favipiravir has been successfully performed. This fluorinated drug has been used to treat Ebola and COVID-19. Because the partially cyclic reaction scheme for photo-CIDNP allows for multiple data acquisitions, averaging further improved the SNR. The mean signal gain factor for 19F has been estimated to be around 1700. An in-plane resolution of 0.39 x 0.39 mm2 enabled the analysis of spatially varying degrees of hyperpolarization. The minimal detectable amount of favipiravir per voxel was about 500 pmol. The results show that 19F photo-CIDNP is a promising method for the non-invasive detection of suitable 19F-containing drugs and other compounds with very low levels of the substance, even when measured in low magnetic fields.
Holmium Laser Lithotripsy and the Analysis of Factors Influencing Postoperative Ureteral Stricture
Authors: He Jia-Wei 
Published: July 2023

Abstract
Background
The thermal damage caused by holmium laser lithotripsy is irreversible and can lead to severe complications, including ureteral strictures.
Methods
This retrospective study included 106 patients who underwent ureteroscopic holmium laser lithotripsy by the same specialist at our hospital between October 2020 to October 2021. Patient data, including information on the stone location, size, surgical time, water consumption, disease course, and presence of stone-associated polyps, were collected and analysed using SPSS 23.0.
Results
Logistic regression analysis of the risk factors for URHL revealed significant associations (P < 0.05) between ureteral strictures and stone location, stone size, operation time, water consumption, disease course, and stone-associated polyps.
Conclusion
Complications during surgery significantly increase when the course of urinary tract stones exceeds 3 months, large ureteral stones are present, long incarceration time is required, and complex conditions, such as polyps, are encountered. The presence of these factors increases the risk of thermal damage due to holmium lithotripsy.
WITHDRAWN: Influence of Raw Rice Hulls in Green Roof Substrates
Authors: Dinçel Hamdi , Ekşi Mert 
Published: July 2023

Abstract
Utilizing local resources and reducing environmental impact during green roof implementation is crucial to maintain the sustainable character of the green roofs. Green roof substrates constitute two main portions, which are organic and inorganic. Inorganic portions of the substrates are mainly responsible for the structural design of the substrate and the organic part handles the plant nutrition and water retention abilities. Therefore, a study was conducted to evaluate the usage potential of a waste material, rice hull, in organic and inorganic portions of the engineered green roof substrates along with vermicompost as a locally available organic material. Substrate blends are designated as RPZV, PZR, and PZV. RPZV blend consists of raw rice hulls 6:1; homogenous mixture of pumice and zeolite 2:1 and vermicompost 2:1 by volume. PZR blend consists of raw rice hulls 2:1 and homogenous mixture of pumice and zeolite with a ratio of 8:1 by volume. PZV blend, a mixture of homogenous mixture of pumice and zeolite 8:1 and vermicompost 2:1 by volume. Measurements such as plant growth index, chlorophyll fluorescence, biomass accumulation were performed on some native and exotic plant species including Allium schoenoprasum, Cistus creticus, Lampranthus spectabilis, Dianthus chinensis, Stachys thirkei, Sedum album and Sedum lydium. Findings of the study demonstrated that rice hulls have a potential to use in inorganic portion of the green roof substrates in due primarily to its low bulk density, lower salinity and resistance to degradation but have contrasting effects on substrate water retention when used as an organic part of the substrate. On the other hand, vermicompost amendment tend to hold larger volume of water, providing nutrients to the plant species but caused slight increase on EC levels of the substrate mixtures. Plant species tested in the study including A.schoenoprasum, C.creticus, L.spectabilis are good candidates for extensive green roofs in Mediterranean region.
Title：CHSY1 promotes the tumorigenesis and progression of ovarian cancer. Running title：CHSY1 in ovarian cancer
Authors: Huang Jinling , Feng Qinmei , Wu Huijuan , Xia Sihan Sihan , Wang Liyan , Xia Liangbin 
Published: July 2023

Abstract
Background
Chondroitin synthase-1 (CHSY1) is an enzyme responsible for the biosynthesis of chondroitin sulfate, and it has been reported to be involved in tumorigenesis and progression in several cancer types. However, little is known about CHSY1 in ovarian cancer (OC).
Methods
CHSY1 expression was analysed on a tissue microarray (TMA) including tumour and peritumour tissues of OC patients, and the correlations between CHSY1 and clinicopathological features and prognosis. Gene sequencing analysis and qRT‒PCR were used to identify downstream genes and pathways. Cell function assays were used to assess cell proliferation, invasion and metastasis.
Results
The study revealed that CHSY1 expression was increased in OC vs. peritumour tissues and positively correlated with prognosis. In vitro cell function assays revealed high CHSY1 expression in OC cells, and CHSY1 was able to promote tumour cell proliferation and tumour cell invasion. Gene sequencing analysis and qRT‒PCR confirmed that CHSY1 promotes OC tumorigenesis through the downstream gene TIAM1 and the ERK signalling pathway.
Conclusion
Our study revealed a novel role of CHSY1 in OC tumorigenesis and offered a possible therapeutic target for OC.
The acid-sensing nociceptor TRPV1 controls breast cancer progression in bone via regulating HGF secretion from sensory neurons
Authors: OKUI TATSUO , Hiasa Masahiro , Hata Kenji , Roodman G David , Nakanishi Masako , Yoneda Toshiyuki 
Published: July 2023

Abstract
Cancers showing excessive innervation of sensory neurons (SN) in their microenvironments are associated with poor outcomes due to promoted growth, increased tumor recurrence, metastasis, and cancer pain, suggesting SNs play a regulatory role in cancer aggressiveness. Using a preclinical model in which mouse 4T1 breast cancer (BC) cells were injected into the bone marrow of tibiae, we found 4T1 BC cells aggressively colonized bone with bone destruction and subsequently spread to the lung. Of note, 4T1 BC colonization induced the acidic tumor microenvironment in bone in which SNs showed increased innervation and excitation with elevated expression of the acid-sensing nociceptor transient receptor potential vanilloid-1 (TRPV1), eliciting bone pain (BP) assessed by mechanical hypersensitivity. Further, these excited SNs produced increased hepatocyte growth factor (HGF). Importantly, the administration of synthetic and natural TRPV1 antagonists and genetic deletion of TRPV1 decreased HGF production in SNs and inhibited 4T1 BC colonization in bone, pulmonary metastasis from bone, and BP induction. Our results suggest the TRPV1 of SNs promotes BC colonization in bone and lung metastasis via up-regulating HGF production in SNs. The SN TRPV1 may be a novel therapeutic target for BC growing in the acidic bone microenvironment and for BP.
Residual properties and durability of GFRP composite exposed to alkaline solution and natural weather for a decade
Authors: Sawpan Moyeenuddin Ahmad , Beg Mohammad 
Published: July 2023

Abstract
This paper presents a comprehensive analysis of the residual thermal and mechanical properties of pultruded GFRP composite rebar following a decade of conditioning in an alkaline solution and exposure to natural weather conditions. The study focuses on evaluating the changes in the glass transition temperature (Tg) of the polymer matrix and its impact on the rebar's mechanical performance. The results indicate that the Tg retained approximately 94.7% of its initial value, with the decrease attributed to the plasticizing effect of absorbed water. The flexural modulus, flexural strength, and transverse shear strength were found to retain 91.8%, 77.2%, and 97.3% of their original values, respectively. The reductions in strength and stiffness were primarily attributed to a weakening in the bonding between the fibres and the polymer matrix. Fractographic analysis revealed that the failure of the plasticized and softened polymer matrix contributed to the observed reductions in strength. Interestingly, the short beam shear strength remained relatively unchanged, as the diffusion of water into the core of the rebar at ambient temperatures had a minimal effect. This slower water diffusion in the core led to insignificant degradation of the short beam shear strength.
Seasonal Assemblages of picocyanobacteria in the subtropical segment of the Kuroshio Current
Authors: Chan Ya-Fan , Chung Chih-Ching , Gong Gwo-Ching , Lin I-Jung , Hsu Ching-Wei 
Published: July 2023

Abstract
A long-term observation has been conducted on the community composition diversity of picoplankton in the subtropical segment of Kuroshio Current from 2009 to 2015. The results showed that Synechococcus mainly distributed in the surface water layer regardless of seasonal changes, and the number of cells ranged from 104 to 105 cells mL− 1. In contrast, the maximum value of Prochlorococcus was maintained at more than 105 cells mL− 1 throughout the year, and the stirring effect caused by the monsoon determined their distribution in the water layer. In the summer and the autumn, Prochlorococcus were mainly concentrated at the water layer near the bottom of the euphotic zone. In the spring and the winter, they were evenly distributed in the euphotic zone. In addition, the results of 16S rRNA gene diversity analysis showed that the seasonal changes in the relative abundance of Synechococcus and Prochlorococcus in the surface water of each station accounted for 20 to 40% of the total reads. Proteobacteria and Actinobacteria approximately accounted for 45% and 10% of the total picoplankton in the four seasons. The clade-II of Synechococcus and the High-light II of Prochlorococcus were the dominant strains in the waters all year round. These data will be important basic parameters for us to study the impact of global environmental changes on marine biogeochemical cycles in the western boundary currents in the future.
Analyze of the socio-economic drivers of land use land cover changes in Western Ethiopia
Authors: Bekere Jembere , Senbeta Feyera , Gelaw Abren 
Published: July 2023

Abstract

A variety of socioeconomic and environmental factors have contributed to changes in LULC around the world in recent years. This study examines the socioeconomic factors that accelerated LULC in Western, Ethiopia. Data was generated from landsat images and through both primary and secondary sources. Primary data include household survey, field observation, group discussion; key informants’ and interviews. Landsat images classified with supervised classification technique and maximum likelihood classifier through arc GIS 10.3 to develop LULC maps of the study area. Accuracy assessment and kappa coefficient were used to approve the accuracy of the classified LULC, and farm land, settlement, bare land, forest land, and water body were the major LULC classes in the District. Forest cover in three decades (1990–2020) decreased from 12.1% in 1990 to 2.6% in 2020 in the study area. Binary logistic regression model examined the relationship between the (dependent) and the main socioeconomic (independent) variables. A logistic regression was performed to ascertain how independent variables and the driving forces for LULC change (Natural forces or anthropogenic forces) and the model was statistically significant (x2 = 23.971, df = 5, P < 0.001).The model explained 13.9% (Nagelekerke R2) of the variance in the driving forces for LULC dynamics and correctly classified 66.1% of cases. The study identified Age, Gender, Educational status and landholding sizes significantly determine driving forces for LULC dynamics and have the greatest chance to choice the anthropogenic forces. Thus relevant stakeholders should take integrated actions to decrease the driving forces for LULC dynamics through restoration of landscape.
Atorvastatin improves intestinal mucositis induced by 5-fluorouracil in mice by modulating the and epithelial barrier and inflammatory signaling pathways
Authors: Vital Kátia Duarte , Pires Luiz Octavio , Gallotti Bruno , Silva Janayne Luihan , Jesus Luís Cláudio Lima , Alvarez-Leite Jacqueline Isaura , Ferreira Ênio , Azevedo Vasco Ariston Carvalho , Martins Flaviano Santos , Cardoso Valbert Nascimento , Fernandes Simone Odília Antunes 
Published: July 2023

Abstract
Chemotherapy-induced intestinal mucositis is a major side effect of cancer treatment. Statins are 3-hydroxy-3-methyl glutaryl coenzyme reductase inhibitors used to treat hypercholesterolemia and atherosclerotic diseases. Recent studies have demonstrated that atorvastatin (ATV) has antioxidant, anti-inflammatory, and resulting from the regulation of different molecular pathways. In the present study, we investigated the effects of ATV on intestinal homeostasis in 5-fluorouracil (5-FU)-induced mucositis. Our results showed that ATV protected the intestinal mucosa from epithelial damage caused by 5-FU mainly due to inflammatory infiltrate and intestinal permeability reduction, downregulation of inflammatory markers, such as Tlr4, MyD88, NF-κB, Tnf-a, Il1β, and Il6 dose-dependent. ATV also improved epithelial barrier function by upregulating the mRNA transcript levels of mucin 2 (MUC2), and ZO-1 and occludin tight junction proteins. The results suggest that the ATV anti-inflammatory and protective effects on 5-FU-induced mice mucositis involve the inhibition of the TLR4/MYD88/NPRL3/NF-κB, iNos, and caspase 3 signaling pathways.
Direct and Rapid Synthesis of Arylphosphines (PIII) by Oxalyl Chloride Promoted Reduction of Inorganic Phosphorus Salts [TBA][H2PO4] with Trichlorosilane and Palladium Catalysis
Authors: Wu Xiaofeng , Tian Yaling , Liu Tao , Xu Wenbo , Liu Haichao , Chai Yao , Wang Zhibin , Wang Xi-Cun , Quan Zheng-Jun 
Published: July 2023

AbstractGiven the high demand for organophosphorus compounds (OPCs), developments of sustainable routes toward OPCs synthesis attract much attention. Numerous efforts are contributing to P4transformations into P1chemistry. Nevertheless, the existing methods necessitate energy-immense multisteps often utilize corrosive and dangerous reagents originating from P4/Predallotropes, harmful intermediates, and chemical waste, impeding further exploration and practical applications. Herein, direct and efficient transformation of inorganic phosphates [TBA][H2PO4] into OPCs is demonstrated. These salts were activated by cost-efficient oxalyl chloride at 20°C in 5 minutes, through a double chlorination of OH on phosphorus upon elimination of CO2and CO molecules, followed by reducing the resultant intermediate with trichlorosilane, then coupling with haloaryls under palladium-catalysis to provide desired OPCs. Diverse OPCs with tolerance of various functionalities on aryl halides achieved with potential scale-up and industrial applications, eliminating the reliance on extortionate, problematic P4allotropes. X-ray diffraction and DFT calculations revealed activated intermediate [TBA][PO2Cl2].
Long-term organic amendments enhanced soil organic carbon storage and stability in a typical paddy soil of Southern China
Authors: Chen Xianni , Xu Hu , Mustafa Adnan , Huang Qinghai , Liu Kailou , Sun Nan , Xu Minggang 
Published: July 2023

Abstract
Background
The contribution of long-term fertilization to soil organic carbon (SOC) storage in arable soils is well acknowledged. The present study soil samples were collected from a 29 years long field trial in a red paddy soil of Jiangxi province, southern China to assess the effects of long-term fertilization on SOC storage and stability in top and sub-soil layers. The SOC storage of whole soil and SOC fractions were quantified at three soil depths (0–20, 20–40, 40–60 cm) under four treatments: no fertilization (Control), a combination of nitrogen, phosphorus and potassium (NPK), double the rates of NPK (2NPK), NPK plus manure (NPKM).
Results
The results showed that the effect of inorganic fertilizer application on SOC storage across the soil profile (0–60 cm) was negligible except for the 2NPK treatment. The larger SOC storage of the Non-labile C fraction was observed in the 2NPK (25.0 t C·ha− 1) and NPKM (23.8 t C·ha− 1) treatments compared to other treatments, and the NPKM treatment significantly (p < 0.05) accreted the SOC storage of less-labile C fraction by 46.7% averagely compared to other treatments. Besides, the SOC storage of passive pool (less-labile C + non-labile C) under NPKM was 30.7% higher than that in the Control. This was further supported by the higher proportion of passive than active pool indicating that fertilization, especially organic combined with inorganic fertilization, improved soil C stability. Additionally, the effect of different fertilization on SOC storage was mainly reflected in the surface soil, while very weak in the deeper soil as revealed by the stratification ratio and C sequestration rate.
Conclusion
Inorganic fertilizer combined with organic fertilizer have the ability to increase the storage and stability of SOC which further depend on annual C input and differences in soil depths. Taken together, in red paddy soil, the current fertilization had a significant effect on changing the dynamics of SOC in the topsoil, but a weak effect on the subsoil.
Farmers’ participation decision in high value market and its effect on food security of smallholder avocado producers in Sidama region, Ethiopia
Authors: Legesse Tibebu , Ashebir Aneteneh , Kebede Kehabtimer 
Published: July 2023

Abstract
Food insecurity is an enduring, critical challenge in Ethiopia. Linking farmers to high-value markets continue to be a viable option for breaking the food insecurity. Many studies have emphasized on factors determining smallholders’ participation in high value markets. Despite their undeniable importance, these studies have methodological limitations since they neglected the importance of this for food security. Thus, this study aimed to fill a knowledge gap in the area by investigating the factors influencing smallholder avocado farmers’ participation in a high-value market channels and how it impacts households' food security in the study area. This study employed a cross-sectional research design and multistage sampling techniques to achieve the objectives of the study. Both primary and secondary data were collected. The primary data were collected from randomly selected 389 avocado producers using a semi structured questionnaire. Secondary data were collected from journals, annual reports, websites and different published and unpublished materials. Descriptive statistics, inferential statistics, and propensity score matching model were used to analyze the data. The result of the binary logit model revealed that the participation of avocado producers in a high-value market channels was influenced by age, educational status, the quantity of avocados sold, and price of avocado in quintal and market information. The ATT estimation of PSM model indicated that the participation in high-value market channels had a positive and significant influence on the food security in the study area. Given the substantial contributions participation in the high-value market channels to food security, concerned bodies in Ethiopia should encourage more households to participate in the high-value market channels.
Gender Inequality, Income Inequality, Educational Inequality and Economic Growth Across Continents of the World
Authors: Aidoo Daniel Kwame , Donkoh Joana Antwi 
Published: July 2023

Abstract
This paper investigated the effects of gender inequality, income inequality, educational inequalityand economic growth across continents of the world. Specifically, six continents consisting of Africa, Asia, Europe, North America, Oceania and South America were used. The study design was cross sectional in nature. Secondary source of information on gender inequality, unequal access to education as well as Gini coefficient as an intermediary for income inequality were obtained on six continents of the world from the UNDP Human Development Report 2021/2022. The retrieved data were disaggregated based on the six continents and analysed using Lease square regression to show the associations between gender inequality, income inequality, educational inequality and economic growth respectively. The sorted data was subjected to statistical analysis using IBM-SPSS Version 26. Kuznets and social justice theories served as the theoretical footings on which the study is premised. Findings revealed that inequality in education decreased the economic growth of Africa, Europe and North America. Also, gender inequality increased the economic growth of Asia and Europe. Additionally, Africa was the only country that showed increasing gender inequality was associated with decreasing economic growth. The study recommended that Africa leaders should put equity measures in place to reduce inequality in education as well as gender inequality to improve the economic growth of the continent. Again, leaders of Europe and North America should initiate educational equality policies to promote the economic growth of their continents.