bluuebunny/crossref_metadata_2025_split huggingface dataset:
Image‐based analysis of complex microstructures using the finite cell method
Authors: Gorji Mahan , Komodromos Michail , Grabe Jürgen , Düster Alexander 
Published: May 2023

AbstractGeometry conforming meshing techniques such as the finite element method (FEM) face a big challenge when dealing with complex and heterogeneous microstructures. Therefore, efficient simulation methods are needed combining accurate morphological reproducibility and computational efficiency. For such problems, the finite cell method (FCM) is a promising approach, which uses a Cartesian grid – independent of the geometry – leading to a fast and efficient mesh generation. However, to handle complex microstructures such as cemented sands the FCM is not sufficient anymore. Therefore, three different versions of the FCM are presented: first, the FCM, which is directly applied to CT scans (denoted as “VoxelFCM”). Second, the FCM combined with a global L2‐projection, leading to a smooth geometry description (denoted as “FCM”). And finally, the FCM with L2‐‐projection, which is extended by a local enrichment to capture weak discontinuities at the interfaces between the different phases (denoted as “FCM‐Enrichment”). First, in a numerical study, the different versions of the FCM are investigated. Then, these methods are verified against the FEM. Finally, these methods are used to gain a deeper insight into the micromechanical phenomena of cemented sands under compressive loading.
Numerical investigation on the performance of a Solar Chimney Power Plant System (SCPP)
Authors: Laouar Roudouane , Wuensch Olaf 
Published: May 2023

AbstractIn this work, a parametric two‐dimensional computational fluid dynamics (CFD) analysis of solar chimney power plant was performed to describe the physical mechanism in order to establish realistic predictions for the operation of such plants in different location in Algeria. The developed numerical model includes a solar radiation model within the collector; an energy storage model; an air flow and heat transfer model, and a turbine model. It is based on the solution of the Navier‐Stokes equation for turbulent flow using the standard k − ϵ model. The Boussinesq model was adopted in this simulation for the density of the fluid. The boundary conditions were adapted according to the selected sites and the effect of this on the SCPP performance was studied. The numerical simulation was performed using the commercial computational fluid dynamics (CFD) code “Ansys Fluent 19.2”.
Batagay megaslump: A review of the permafrost deposits, Quaternary environmental history, and recent development
Authors: Murton Julian , Opel Thomas , Wetterich Sebastian , Ashastina Kseniia , Savvinov Grigoriy , Danilov Petr , Boeskorov Vasily 
Published: May 2023

AbstractThe Batagay megaslump, in the Yana Uplands of northern Yakutia, Russia, is the largest known retrogressive thaw slump in the world. The slump exposes a remarkable sequence of Ice Age permafrost deposits that record the interaction of colluvial, eolian and periglacial processes on a hillslope episodically forested during the last 650 ka or more in response to climate variability on glacial–interglacial timescales. Numerous bones, teeth, and occasional carcasses of Pleistocene and Holocene mammals have been recovered from the permafrost. The megaslump developed over the course of several decades in three stages: (1) gullying, (2) thaw slumping, and (3) megaslumping. After disturbance to the taiga vegetation cover in the 1940s–1960s, a hillslope gully formed by the early 1960s. The gully initiated thaw slumping along its central part during the 1980s, with the slump enlarging to megaslump (>20 ha) proportions during the 1990s. By 2019, the area of the slump had reached about 80 ha and its headwall above the slump floor was up to about 55 m high. The main geomorphic processes of slump growth are headwall ablation and thermal erosion, producing a distinctive terrain of icy badlands on the slump floor. Though much of the megaslump is rapidly growing at present, it will probably stabilize eventually as an irregular terrain characterized by sandy ridges and sand‐filled elongate depressions formed by degradation of the badlands. Comparison of the Batagay megaslump with megaslumps from northwest Canada reveals several similarities and differences in terms of their geomorphology, permafrost deposits, and Quaternary history.
A Curcumin‐Based MOF Embedded Ag NPs and Modified with Polydopamine for Dual‐Drug Delivery and Dual Biological Window Responsive Synergetic Cancer Therapy
Authors: Zhang Xuan , Zhao Zhihuan , Xu Min , Yang Shasha , Xie Yiliang , Zhang Bing , Fan Jimin 
Published: May 2023

AbstractA dual‐drug delivery, pH‐responsive composite nanoplatform (MAPD NPs) that can respond to two biological windows is developed to improve the efficacy of synergetic chemotherapic/photothermal/chemodynamic therapy (CDT) against tumors. This nanoplatform is surface‐modified polydopamine (PDA) with excellent biocompatibility as the shell and Ag NPs as the catalyst for CDT. The curcumin (Cur) acts as an organic ligand to be encapsulated in metal−biomolecule frameworks (Bio‐MOFs) by self‐assembly, and Bio‐MOF acts as a delivery carrier to deliver of DOX•HCl and then releases the Cur when it degrades in vivo. Moreover, Bio‐MOF can be taken up by cells faster and accelerate cell death compared to free Cur. PDA modification enables MAP (PDA@MOF‐Ag) to have photothermal properties under 808 and 1064 nm light irradiation, which not only improves the biocompatibility of MAP but also makes it produce high heat and abundant ·OH. The photothermal performance of MAP is stable after irradiation at 808 or 1064 nm, and the photothermal conversion efficiency reaches 63.57% and 26.25%. The survival rate of HeLa cells co‐incubation with MAPD NPs after irradiation at 808 and 1064 nm decreases to 19.52 ± 0.69% and 30.48 ± 0.49%, respectively, providing a feasible scheme for the realization of deep tumor killing.
An assessment of quality of life among stroke survivors at tertiary care teaching hospital in South India: A randomized clinical trial
Authors: Mary Priya , Sivannan Srinivasan , Elumalai Karthikeyan , Williams Helan , Abhilash Vijayan , Srinivasan Sivaneswari , Cheriyan Binoy Varghese , Devaraji Mahalakshmi 
Published: May 2023

AbstractThe study's primary aim was to examine how a stroke affects health‐related quality of life (QoL), and a secondary aim was to link this event with clinical and sociodemographic factors. Stroke patients were included in the study. First, 94 patients underwent a quantitative analytical cross‐sectional study 3 months after starting medication. Using multivariable linear regression, relationships between the severity of the initial stroke were investigated. From the raw data, we determined the standard deviation and the standard error of the mean. If the p‐value is less than .05, it is considered significant, and if it's less than .0001, it is extremely significant. The majority 94.68% were diagnosed with ischemic stroke, and only 5.32% were hemorrhagic stroke; 56.32% of the patients were male, and 43.68% were female; one‐third of the patients were found to be smokers and alcoholics; 9.57% of the patients had a family history of stroke; and 9.5% of the patients had a history of stroke. Patients with stroke comorbidities, including high blood pressure 88.19%, diabetes 51.06%, high cholesterol 22.34%, coronary artery disease 23.40%, smoking 30.85%, and alcoholism 24.46%. Significant dangers were posed by both hypertension and smoking. There was a statistically significant improvement in quality of life between the two groups, with the intervention group showing a mean difference of 112. The p‐value for this improvement was less than .0001. The quality of life of stroke survivors can be improved through direct screening, monitoring of the patient, planned therapy, and management.
To split or not to split: CASP15 targets and their processing into tertiary structure evaluation units
Authors: Kryshtafovych Andriy , Rigden Daniel J. 
Published: May 2023

AbstractProcessing of CASP15 targets into evaluation units (EUs) and assigning them to evolutionary‐based prediction classes is presented in this study. The targets were first split into structural domains based on compactness and similarity to other proteins. Models were then evaluated against these domains and their combinations. The domains were joined into larger EUs if predictors’ performance on the combined units was similar to that on individual domains. Alternatively, if most predictors performed better on the individual domains, then they were retained as EUs. As a result, 112 evaluation units were created from 77 tertiary structure prediction targets. The EUs were assigned to four prediction classes roughly corresponding to target difficulty categories in previous CASPs: TBM (template‐based modeling, easy or hard), FM (free modeling), and the TBM/FM overlap category. More than a third of CASP15 EUs were attributed to the historically most challenging FM class, where homology or structural analogy to proteins of known fold cannot be detected.
Simultaneous regression of non‐small cell lung cancer and orbital extranodal marginal zone lymphoma with chemoradiotherapy for lung cancer
Authors: Oi Issei , Saito Zentaro , Ito Takanori , Imakita Takuma , Kanai Osamu , Fujita Kohei , Tachibana Hiromasa , Mori Minako , Moriyoshi Koki , Mio Tadashi 
Published: May 2023

AbstractThis report describes the case of a 79‐year‐old Japanese man diagnosed with orbital extranodal marginal zone lymphoma (EMZL) and stage IIIA lung cancer. The patient received concurrent chemoradiation for lung cancer with carboplatin/paclitaxel treatment, resulting in regression of both the lymphoma and lung cancer. To our knowledge, this is the first reported case of concurrent orbital EMZL and lung cancer. In this case, a treatment strategy that prioritized lung cancer treatment was deemed appropriate. This case suggests that chemotherapy with carboplatin and paclitaxel may serve as an effective treatment for both lung cancer and lymphoma.
Chlormadinone acetate in progestin‐primed ovarian stimulation does not negatively affect clinical results
Authors: Shibasaki Sena , Hattori Hiromitsu , Koizumi Masae , Nagaura Satoko , Toya Mayumi , Igarashi Hideki , Kyono Koichi 
Published: May 2023

AbstractPurposeTo investigate whether progestin‐primed ovarian stimulation (PPOS) with chlormadinone acetate (CMA) adversely affects clinical results and neonatal outcomes, or causes congenital deformities.MethodsThis retrospective study was conducted at private IVF clinic from November 2018 to November 2021. Women underwent oocyte retrieval using gonadotropin‐releasing hormone (GnRH) antagonist protocol (n = 835) or PPOS protocol (n = 57) were included. Eligible patients were normal ovarian responders (aged <40, AMH ≧1.0 ng/mL) with freeze‐all cycle. Embryo developments, clinical results, or neonatal outcomes of singletons derived from transfer of frozen single blastocysts were compared within each group.ResultsPatient characteristics were similar in both groups. The median LH level (mIU/mL) at trigger in the GnRH antagonist group [2.0 (1.2–3.7)] was significantly higher than in the PPOS group [0.9 (0.3–1.7)]. There was no cycle with premature LH surge in the PPOS group. Fertilization and blastocyst formation rates did not differ significantly between groups. Furthermore, clinical outcomes were also similar in the two groups. Congenital abnormality rates did not differ significantly [0.9% (3/329), 0.0% (0/17)].ConclusionsCMA using ovarian stimulation did not negatively affect clinical results. Our data suggest that PPOS with CMA is an appropriate ovarian stimulation method for normal ovarian responders.
Fully distributed secure consensualization for leaderless nonlinear multiagent systems with communication link attacks
Authors: Zhao Miao , Xi Jianxiang , Wang Le , Xia Kehan , Zheng Yuanshi 
Published: May 2023

AbstractThe secure consensualization for leaderless nonlinear multiagent systems with communication link attacks is realized in a fully distributed manner in a certain sense that the gain matrix design do not depend on the communication topology. A new virtual reference state estimator is proposed for each agent to estimate the common tracking state, which can adaptively adjust coupling strengths to counteract the influence of communication link attacks. Then, by the Lipschitz condition and the special structure property of the time‐varying nonsingular transformation matrix, the influence of the Lipschitz nonlinearity on secure consensus is linearized, and a design approach of the secure consensus control gain is given on the foundation of the linear matrix inequality. Finally, a numerical example is provided to demonstrate the effectiveness of theoretical results.
Partial pulpectomy of a tusk fracture with pulp exposure in a North Sulawesi babirusa (Babyrousa celebensis)
Authors: Dreyer Saskia , Grund Lisa , Klein Christian , Lawrenz Arne , Fischer Dominik 
Published: May 2023

AbstractA 6‐year‐old, male North Sulawesi babirusa (Babyrousa celebensis) kept at a zoological institution, suffered a tusk fracture of unknown origin, associated with pulp exposure and a relapse of the fracture after 10 months. In other tusked animals, endodontic therapy has been reported to treat acute pulp exposure and to preserve the growing tusk. Therefore, a partial pulpectomy was attempted in the babirusa, combined with systemic antibiotic and anti‐inflammatory therapy. Under general anaesthesia, the partial pulpectomy was performed twice, followed by a direct pulp capping with mineral trioxide aggregate and closure of the coronal pulp opening using glass ionomer cement and composite. Partial pulpectomies have been performed in babirusas before, but using mineral trioxide aggregate as pulp capping is a novel treatment regimen. It was performed without complications, and the tusk continued to grow. Over a follow‐up period of 14 months, the tusk was successfully preserved in absence of any relapse or instability.
Hybrid governance, environmental justice, and hydropower development in the Mekong transboundary commons
Authors: Yong Ming Li 
Published: May 2023

AbstractThe transboundary Mekong River spans China, Myanmar, Laos, Thailand, Cambodia, and Vietnam, and provides critical ecosystem services that support millions of people across the river basin. However, the exploitation of its water resources for state‐led development, especially in the realm of hydropower development, not only threatens the livelihoods and food security of communities across the river basin, but also reveal the challenges of governing the Mekong River as a transboundary commons. In focusing on how environmental injustice is produced through hydropower development and the power dynamics within hybrid governance arrangements in the Mekong River Basin, this paper seeks to examine how a grounded perspective of environmental justice may be understood in this context by linkages between the principles of environmental justice and the Mekong literature in three ways. First, the production of, and challenges against distributive injustice in the Mekong River Basin must engage with a strong tradition of scalar analysis in the field of transboundary water governance, particularly in understanding how a politics of scale underlies contestations around the Mekong River. Second, the principle of justice as recognition can be situated within a body of literature that interrogates the politics of knowledge that runs through Mekong water governance, although the co‐production of knowledge types must be acknowledged. Finally, a recent body of literature questioning the legality of dam‐building and public participation around Mekong hydropower dams are closely tied to issues of procedural justice, and reveal the importance of recognizing plurality in ideas around transparency and accountability.This article is categorized under:Human Water > Water GovernanceHuman Water > Water as Imagined and RepresentedHuman Water > Value of Water
Einleitung
Authors: Katter Valentin 
Published: May 2023

ZusammenfassungDer Stellenwert der Trigonometrie in den Kernlehrplänen der Sekundarstufe I und II variiert deutlich in den unterschiedlichen Bundesländern. In Nordrhein-Westfalen reicht es beispielsweise, die Ableitung der Sinusfunktion schlichtweg zu nennen, wohingegen sich die Schülerinnen und Schüler in Bayern die Ableitungsfunktion auf graphischem Weg plausibel machen sollen. In Berlin sollen die Schülerinnen und Schüler den Sinus- und Kosinussatz nutzen, um in beliebigen Dreiecken Seitenlängen zu bestimmen, während in Niedersachsen die beiden Sätze nicht auftauchen.
Einleitung
Authors: Ruppel Samantha 
Published: May 2023

ZusammenfassungDieses Kapitel bietet einen ersten Einblick und Überblick in das hier vorliegende Buch. Es wird argumentiert, dass wenn lokale Akteur*innen von Beginn in Friedenprozesse eingebunden werden, es wichtig ist, die Beziehungen der beteiligten Akteur*innen zueinander im Blick zu haben. Das Kapitel gibt eine kurze Einführung in Zivile Konfliktbearbeitung und lokale Akteur*innen und den für die Forschung verwendeten reflexiven Forschungsansatz.
Konzeptioneller Rahmen
Authors: Ruppel Samantha 
Published: May 2023

ZusammenfassungDieses Kapitel erarbeitet einen konzeptionellen Rahmen, indem es verschiedene theoretische Überlegungen zu Peacebuilding und insbesondere zur Einbeziehung lokaler Akteur*innen diskutiert. Die hier dargestellten theoretischen Konzepte sind im Sinne der Methode als Werkzeugkasten zu verstehen, um anschließend darstellen zu können, wie die theoretische, normative Ebene in der Praxis aussieht. Generell gelten die theoretischen Konzepte als Erwartungshorizont, der den Blick für die eigentliche Forschung schärft.
Biofilm-forming strains of P. aeruginosa and S. aureus isolated from cystic fibrosis patients differently affect inflammatory phenotype of macrophages
Authors: Ciszek-Lenda Marta , Majka Grzegorz , Suski Maciej , Walczewska Maria , Górska Sabina , Golińska Edyta , Fedor Angelika , Gamian Andrzej , Olszanecki Rafał , Strus Magdalena , Marcinkiewicz Janusz 
Published: May 2023

Abstract
Objective
Lung cystic fibrosis (CF) is characterized by chronic infections and hyperinflammatory response of neutrophils and macrophages. P. aeruginosa (PA) and S. aureus (MSSA, MRSA) are major pathogens of advanced CF. The main goal of this study was to compare the inflammatory phenotype of murine C57BL/6 macrophages exposed to PA57 with that exposed to MSSA60, both strains isolated from the same patient with severe CF. In the present study, we used C57BL/6 mice sensitive to lung infection with P. aeruginosa.

Methods
We measured the release of cytokines and the expression of phenotypic markers of murine neutrophils and macrophages exposed to bacterial cells and biofilm components (i.e., EPS) of the selected bacteria. In addition, a quantitative proteomic approach was used for the characterization of proteome-wide changes in macrophages.

Results
Neutrophils stimulated with PA57 and MSSA60 strains produced hyperinflammatory pattern of cytokines. The pro-inflammatory impact of PA57 was significantly higher than that of MSSA60 (IL-6/IL-10 ratio: PA57 = 9.3 vs. MSSA60 = 1.7). Macrophages produced significantly lower amount of cytokines, but showed classical pattern of M1 markers (iNOS-High; arginase-1 and mannose receptor MRC1-Low). Importantly, as evidenced by proteomic analysis, PA57 and PA57-EPS were stronger inducers of M1 macrophage polarization than the MSSA60 counterparts.

Conclusions
Our study demonstrated that strong biofilm P. aeruginosa strains, CF isolates, are dominant inducers of M1 macrophages, termed biofilm-associated macrophages (BAMs). We suggest that repolarization of detrimental BAMs might be a new therapeutic strategy to ameliorate the airway damage in CF.
On $$\kappa $$-Pseudocompactess and Uniform Homeomorphisms of Function Spaces
Authors: Krupski Mikołaj 
Published: May 2023

AbstractA Tychonoff spaceXis called$$\kappa $$κ-pseudocompactif for every continuous mappingfofXinto$$\mathbb {R}^\kappa $$Rκthe imagef(X) is compact. This notion generalizes pseudocompactness and gives a stratification of spaces lying between pseudocompact and compact spaces. It is well known that pseudocompactness ofXis determined by the uniform structure of the function space$$C_p(X)$$Cp(X)of continuous real-valued functions onXendowed with the pointwise topology. In respect of that A.V. Arhangel’skii asked if analogous assertion is true for$$\kappa $$κ-pseudocompactness. We provide an affirmative answer to this question.
Classical Orthogonal Polynomials Revisited
Authors: Castillo K. , Petronilho J. 
Published: May 2023

AbstractThis manuscript contains a small portion of the algebraic theory of orthogonal polynomials developed by Maroni and their applicability to the study and characterization of the classical families, namely Hermite, Laguerre, Jacobi, and Bessel polynomials. It is presented a cyclical proof of some of the most relevant characterizations, particularly those due to Al-Salam and Chihara, Bochner, Hahn, Maroni, and McCarthy. Two apparently new characterizations are also added. Moreover, it is proved through an equivalence relation that, up to constant factors and affine changes of variables, the four families of polynomials named above are the only families of classical orthogonal polynomials.
Underflow concentration prediction based on improved dual bidirectional LSTM for hierarchical cone thickener system
Authors: Lei Yongxiang , Karimi Hamid Reza 
Published: May 2023

AbstractIn the practical thickener cone systems, the underflow concentration is hard to measure through physical sensors while there exist the high cost and significant measurement delay. This paper presents a novel and deeply efficient long short-time memory (DE-LSTM) method for concentration prediction in the deep cone thickener system. First, the DE-LSTM for thicker systems is developed for feature learning and long temporal preprocessing. Then, the feedforward and reverse LSTM subnetworks are employed to learn the robust information without loss. At last, the experimental verification of an industrial deep cone thicker demonstrates the proposed DE-LSTM’s performance outperforms other state-of-the-art methods.
The effect of RFSSW parameters on load capacity of EN AW-6082-T6 aluminum alloy and AlCu bimetallic joints
Authors: Kubit Andrzej , Faes Koen , Trzepieciński Tomasz , Żaba Krzysztof , Kaščák Ľuboš 
Published: May 2023

Abstract
This paper presents research into the creation of refill friction stir spot welding (RFSSW) single-lap joints of 6082-T6 aluminum alloy and roll-bonded AlCu bimetallic sheet. The latter sheet comprises aluminum EN AW-1050A and electrolytic copper M1E in Z6 temper condition (after rolling) and with a 1:1 ratio of the Cu:Al layers. The welding parameters involved a variable plunge depth and welding time. The mechanical properties of the joints were determined in tensile/shear tests. The highest average value of the load capacity of the joint was observed in joints made with a tool plunge depth dt = 2.6 mm and total welding time tw = 4 s. The load capacity for this variant was an average of 5986.75 N with standard deviation SD = 166.15 N. A plug-type fracture on the aluminum layer of the bimetallic sheet was observed in RFSSW joints produced with a plunge depth of 2.6 mm. Increasing the tool rotational speed and thus generating heat resulted in a plug-type fracture on the upper sheet (aluminum alloy). In the case of joints produced with a plunge depth of 2 mm equal to the thickness of the upper sheet, the type of fracture mode with both welding times was found to be nugget debonding.