bluuebunny/crossref_metadata_2025_split huggingface dataset:
Non-communicable disease comorbidities in HIV patients: diabetes, hypertension, heart disease, and obstructive sleep apnea as a neglected issue
Authors: Hadavandsiri Fatemeh , Shafaati Maryam , Mohammad Nejad Safieh , Ebrahimzadeh Mousavi Mohammad , Najafi Arezu , Mirzaei Mohammad , Narouee Sakineh , Akbarpour Samaneh 
Published: August 2023

AbstractThe present study evaluates the non-communicable disease (NCD) patterns and related risk factors among people living with HIV (PLWH) in Iran. This national cross-sectional survey study was conducted on 1173 confirmed PLWHs with a mean age of 35.35 (56.82 Over 50 years old, 33.90 Under 50 years old) admitted from 15 different provinces in the country. Logistic regression was used to analyze the association of factors with having at least one NCD comorbidity. From 1173 PLWH, 225(19.18%) participants experienced at least one NCD (15.20% and 38.69% among under- and over-50-year-old patients, respectively). The prevalence of heart disease, hypertension, diabetes, and sleep apnea among all patients was 1.59%, 2.05%, 1.55%, and 10.26%, respectively. The similar prevalence for each NCD among those over 50 years was 10.11%, 15.71%, 9.01%, 25.44%, and 1.01%, 1.12%, 1.04%, and 9.23% among those under 50 years, respectively. The odds of being at risk of at least one NCD stood higher in patients over 50 years (ORadj = 2.93, 95% CI 1.96–4.37), married (ORadj = 2.48, 95% CI 1.41–4.35), divorced or widowed (ORadj = 2.78, 95% CI 1.48–5.20), and obese (ORadj = 3.82, 95% CI 2.46–5.91). According to our findings regarding the prevalence of NCDs among patients under 50 years of age, we recommend that policymakers give greater consideration to this group in the screening and care programs for NCDs since adults and the elderly are both vulnerable to the risk factors for developing NCDs.
The influence of calcitriol and methylprednisolone on podocytes function in minimal change disease in vitro model
Authors: Grubczak Kamil , Starosz Aleksandra , Makowska Barbara , Parfienowicz Zuzanna , Krętowska Magdalena , Naumnik Beata , Moniuszko Marcin 
Published: August 2023

AbstractMinimal change disease (MCD), considered one of the major causes of nephrotic syndrome, is a complex pathological condition with disturbances in podocytes’ foot processes. Numerous studies suggested the essential role of vitamin D3 in maintaining proper glomerulus function. However, the data on direct potential of that compound in reference to podocytes are scarce. Thus, here we assessed the influence of calcitriol (active vitamin D3) on podocyte function, apart from commonly used steroids (methylprednisolone). CIHP-1 podocyte cell line was used to implement the LPS-PAN-induced MCD in vitro model. Viability, podocyte-related slit diaphragm proteins, morphology, function as a barrier was evaluated using flow cytometry, RT-PCR, confocal microscopy, and TEER analysis. Calcitriol or methylprednisolone did not affect cell viability. Podocyte-related proteins demonstrated different responses to in vitro treatment compared to previously reported changes in total glomeruli. Podocyte morphology was partially restored in the presence of the tested compounds. In addition, TEER analysis revealed improvement of LPS-PAN-induced cells' function as a barrier when vitamin D3 or steroid was used. In conclusion, a significant potential for modulation of MCD in vitro model podocytes with calcitriol or selected steroids was reported. Further studies on vitamin D3 in context of podocyte-related phenomenon accompanying MCD are of great importance.
Energy and macronutrient intakes in Jordan: a population study
Authors: Al Hourani Huda , Alkhatib Buthaina , Al-Shami Islam , Olaimat Amin N. , Al-Holy Murad , Al-Awwad Narmeen Jamal , Abughoush Mahmoud , Saleh Nada A. , AlHalaika Dima , Alboqai Omar , Al-Jawaldeh Ayoub 
Published: August 2023

AbstractJordan has never conducted a nutrition survey to determine nutrient and energy intakes. The current study aimed to describe the energy and macronutrient consumed by the Jordanian population. A cross-sectional food consumption study was conducted, including a sample of Jordanians using two non-consecutive 24-h dietary recalls (24-h DR) between October 2021 and March 2022. A total of 2145 males and females aged 8 to 85 years old living in households were studied. The average of two 24-h DRs for each individual was converted into energy and nutrient intakes. After measuring weight, height, and waist circumference, the body mass index (BMI) and waist-to-height ratio (WHtR) were calculated. The percentage of under-reporters was higher in women than men (58.2% vs. 45.9%). Adults and older adult women had the highest prevalence of obesity (29.6%), while adults and older adult men had the highest prevalence of overweight (41.4%). There is a significant increase in energy intake in children, boys, and all adults, compared to the recommended calories. The mean energy percentage (E %) of total fat was 38%, exceeding the upper limit of the Acceptable Macronutrient Distribution Range (AMDR). At the same time, the mean daily dietary fiber intake fell below the recommended levels (ranging from 13.5 g in children to 19.5 g in older adults). The study population consumes more fat and less fiber than the recommended levels. Actions must be taken across all age groups to correct the deviation of energy and macronutrient intakes from the recommended dietary allowances.
Mapping brain networks in MPS I mice and their restoration following gene therapy
Authors: Zhu Wei , Ou Li , Zhang Lin , Clark Isaac H. , Zhang Ying , Zhu Xiao-Hong , Whitley Chester B. , Hackett Perry B. , Low Walter C. , Chen Wei 
Published: August 2023

AbstractMucopolysaccharidosis type I (MPS I) is an inherited lysosomal disorder that causes syndromes characterized by physiological dysfunction in many organs and tissues. Despite the recognizable morphological and behavioral deficits associated with MPS I, neither the underlying alterations in functional neural connectivity nor its restoration following gene therapy have been shown. By employing high-resolution resting-state fMRI (rs-fMRI), we found significant reductions in functional neural connectivity in the limbic areas of the brain that play key roles in learning and memory in MPS I mice, and that adeno-associated virus (AAV)-mediated gene therapy can reestablish most brain connectivity. Using logistic regression in MPS I and treated animals, we identified functional networks with the most alterations. The rs-fMRI and statistical methods should be translatable into clinical evaluation of humans with neurological disorders.
Impact of prophylactic hydroxychloroquine on ultrastructural impairment and cellular SARS-CoV-2 infection in different cells of bronchoalveolar lavage fluids of COVID-19 patients
Authors: Chaudhary Shikha , Joshi Arti , Sesham Kishore , Rai Preeti , Kumar Shailendra , Mridha Asit Ranjan , Baitha Upendra , Nag Tapas Chandra , Yadav Subhash Chandra 
Published: August 2023

AbstractMany drugs were recommended as antiviral agents for infection control and effective therapy to reduce the mortality rate for COVID-19 patients. Hydroxychloroquine (HCQ), an antimalarial drug, has been controversially recommended for prophylactic use in many countries, including India, to control SARS-CoV-2 infections. We have explored the effect of prophylactic HCQ from the cells of bronchoalveolar lavage fluids from COVID-19-induced acute respiratory distress syndrome patients to determine the level of infection and ultrastructural alterations in the ciliated epithelium, type II pneumocytes, alveolar macrophages, neutrophils, and enucleated granulocytes. Ultrastructural investigation of ciliated epithelium and type II pneumocytes showed lesser infections and cellular impairment in the prophylactic HCQ+ group than HCQ− group. However, macrophages and neutrophils displayed similar infection and ultrastructural alterations in both patient groups. The enucleated fragments of granulocytes showed phagocytosis of the matured virus in HCQ+ groups. The present report unveils the ultrastructural proof to complement the paradox regarding the role of prophylactic HCQ in COVID-19 patients.
Cross-cultural consistency of image memorability
Authors: Jeong Su Keun 
Published: August 2023

AbstractMemorability refers to the intrinsic property of an image that determines how well it is remembered or forgotten. Recent studies have found that memorability is highly consistent across individuals. However, most studies on memorability were conducted with participants from Western cultures, and the images used in memorability studies were culturally biased. Previous studies implicitly assumed that memorability would be held constant across different cultural groups; however, to the best of our knowledge, this has not yet been empirically investigated. In the current study, we recruited participants from South Korea and the US and examined whether image memorability was consistent across these two cultures. We found that South Korean participants showed greater memory performance for images rated highly memorable by US participants. The current findings provide converging evidence that image memorability is not fully accounted for by individual differences, and suggest the possibility of cross-cultural consistency in image memorability.
Construction and validation of a prognostic model for colon adenocarcinoma based on bile acid metabolism-related genes
Authors: Luo Qinghua , Zhou Ping , Chang Shuangqing , Huang Zhifang , Zeng Xuebo 
Published: August 2023

AbstractColon adenocarcinoma (COAD), one of the common clinical cancers, exhibits high morbidity and mortality, and its pathogenesis and treatment are still underdeveloped. Numerous studies have demonstrated the involvement of bile acids in tumour development, while the potential role of their metabolism in the tumor microenvironment (TME) has not been explored. A collection of 481 genes related to bile acid metabolism were obtained, and The Cancer Genome Atlas-based COAD risk model was developed using the least absolute shrinkage selection operator (LASSO) regression analysis. The Gene Expression Omnibus dataset was used to validate the results. The predictive performance of the model was verified using column line plots, principal component analysis and receiver operating characteristic curves. Then, we analysed the differences between the high- and low-risk groups from training set based on clinical characteristics, immune cell infiltration, immune-related functions, chemotherapeutic drug sensitivity and immunotherapy efficacy. Additionally, we constructed a protein–protein interaction network to screen for target genes, which were further investigated in terms of differential immune cell distribution. A total of 234 bile acids-related differentially expressed genes were obtained between normal and tumour colon tissues. Among them, 111 genes were upregulated and 123 genes were down-regulated in the tumour samples. Relying on the LASSO logistic regression algorithm, we constructed a model of bile acid risk score, comprising 12 genes: CPT2, SLCO1A2, CD36, ACOX1, CDKN2A, HADH, GABRD, LEP, TIMP1, MAT1A, SLC6A15 and PPARGC1A. This model was validated in the GEO-COAD set. Age and risk score were observed to be independent prognostic factors in patients with COAD. Genes related to bile acid metabolism in COAD were closely related to bile secretion, intestinal transport, steroid and fatty acid metabolism. Furthermore, the high-risk group was more sensitive to Oxaliplatin than the low-risk group. Finally, the three target genes screened were closely associated with immune cells. We identified a set of 12 genes (CPT2, SLCO1A2, CD36, ACOX1, CDKN2A, HADH, GABRD, LEP, TIMP1, MAT1A, SLC6A15, and PPARGC1A) associated with bile acid metabolism and developed a bile acid risk score model using LASSO regression analysis. The model demonstrated good predictive performance and was validated using an independent dataset. Our findings revealed that the bile acid risk score were independent prognostic factors in COAD patients.
Increased incidence of live births in implanted day 5 versus day 6 blastocysts following single embryo transfers with PGT-A
Authors: Chen Chien-Hong , Lee Chun-I , Huang Chun-Chia , Chen Hsiu-Hui , Chang Chih-Ying , Cheng En-Hui , Lin Pin-Yao , Chen Chung-I , Lee Tsung-Hsien , Lee Maw-Sheng 
Published: August 2023

AbstractElective single-embryo transfers of euploid or low-level mosaic blastocysts were analyzed in this retrospective study to determine the correlations of live birth (LB) probability with embryonic developmental features of implanted day 5 (D5, n = 245) or day 6 (D6, n = 73) blastocysts using time-lapse (TL) monitoring. According to the logistic regression analyses (adjusted odds ratio [OR] = 0.341, 95% confidence interval [CI] = 0.169–0.685, P < 0.05), the LB probability was negatively associated with the D6 group. The LB rate of the D5 group was higher than the D6 group (88.2% vs. 75.3%; P < 0.05). Compared with the D5 blastocysts, the D6 blastocysts exhibited comparable dysmorphisms except for the multinucleation at the 4-cell stage (10.9% vs. 2.9%, P < 0.05). Moreover, D6 blastocysts had considerably slower developmental kinetics and poorer blastocyst morphologies. Further analysis confirmed that the LB rate was not associated with developmental kinetics or dysmorphisms but rather with blastocyst morphology (inner cell mass [ICM] grade ≤ C vs. ICM grade A, adjusted OR = 0.155, 95% CI = 0.04–0.596, P < 0.05; trophectoderm [TE] grade ≤ C vs. TE grade A, adjusted OR = 0.157, 95% CI = 0.032–0.760, P < 0.05). In conclusion, D6 implanted blastocysts have a considerably lower LB rate than D5 implanted blastocysts. As determined by TL monitoring, the diminished blastocyst morphology can be one of the primary reasons underlying the decreased likelihood of LB.
The meaning of wild: Genetic and adaptive consequences from large-scale releases of domestic mallards
Authors: Lavretsky Philip , Mohl Jonathon E. , Söderquist Pär , Kraus Robert H. S. , Schummer Michael L. , Brown Joshua I. 
Published: August 2023

AbstractThe translocation of individuals around the world is leading to rising incidences of anthropogenic hybridization, particularly between domestic and wild congeners. We apply a landscape genomics approach for thousands of mallard (Anas platyrhynchos) samples across continental and island populations to determine the result of over a century of supplementation practices. We establish that a single domestic game-farm mallard breed is the source for contemporary release programs in Eurasia and North America, as well as for established feral populations in New Zealand and Hawaii. In particular, we identify central Europe and eastern North America as epicenters of ongoing anthropogenic hybridization, and conclude that the release of game-farm mallards continues to affect the genetic integrity of wild mallards. Conversely, self-sustaining feral populations in New Zealand and Hawaii not only show strong differentiation from their original stock, but also signatures of local adaptation occurring in less than a half-century since game-farm mallard releases have ceased. We conclude that ‘wild’ is not singular, and that even feral populations are capable of responding to natural processes. Although considered paradoxical to biological conservation, understanding the capacity for wildness among feral and feral admixed populations in human landscapes is critical as such interactions increase in the Anthropocene.
Superconductivity induced by gate-driven hydrogen intercalation in the charge-density-wave compound 1T-TiSe2
Authors: Piatti Erik , Prando Giacomo , Meinero Martina , Tresca Cesare , Putti Marina , Roddaro Stefano , Lamura Gianrico , Shiroka Toni , Carretta Pietro , Profeta Gianni , Daghero Dario , Gonnelli Renato S. 
Published: August 2023

AbstractHydrogen (H) plays a key role in the near-to-room temperature superconductivity of hydrides at megabar pressures. This suggests that H doping could have similar effects on the electronic and phononic spectra of materials at ambient pressure as well. Here, we demonstrate the non-volatile control of the electronic ground state of titanium diselenide (1T-TiSe2) via ionic liquid gating-driven H intercalation. This protonation induces a superconducting phase, observed together with a charge-density wave through most of the phase diagram, with nearly doping-independent transition temperatures. The H-induced superconducting phase is possibly gapless-like and multi-band in nature, in contrast with those induced in TiSe2 via copper, lithium, and electrostatic doping. This unique behavior is supported by ab initio calculations showing that high concentrations of H dopants induce a full reconstruction of the bandstructure, although with little coupling between electrons and high-frequency H phonons. Our findings provide a promising approach for engineering the ground state of transition metal dichalcogenides and other layered materials via gate-controlled protonation.
Betacyanins obtained from alternative novel sources as natural food colorant additives: incorporated in savory and sweet food products
Authors: Roriz Custódio Lobo , Carocho Márcio , Alves Maria José , Rodrigues Paula , Morales Patricia , Ferreira Isabel C. F. R. , Heleno Sandrina A. , Barros Lillian 
Published: August 2023

The aim of this study was to assess the performance and stability of betacyanin compounds present in enriched extracts of red-fleshed pitaya peels (Hylocereus costaricensis) and the flowers of Amaranthus caudatus; as natural food colorants.
Transient dark ribbons at the outer boundaries of sunspot superpenumbrae in the chromosphere
Authors: Xu Chengzhi , Zhang Jun , Ding Tao 
Published: August 2023

Context. Although the flow of material in sunspot superpenumbrae has been studied intensively, detailed observations about the evolution of material flow at the outer boundaries of sunspot superpenumbrae are rare.
Aims. We study the evolution of the flow of material at the outer boundaries of superpenumbrae.
Methods. Based on Hα observations from the New Vacuum Solar Telescope, we tracked the evolution of the flow of material at the outer boundaries of superpenumbrae in the chromosphere. Data from the Solar Dynamics Observatory Helioseismic Magnetic Imager were employed to examine the photospheric magnetic field environment relevant to the material flow.
Results. We observed transient dark ribbons (TDRs) at the outer boundary of a sunspot superpenumbra in the chromosphere on 2018 May 12. The TDRs are located in the middle of the sunspot and a flocculus, and both of them have negative magnetic fields. While the ratio of the length and width of a TDR is greater than 8, we tracked the TDR from its formation to disappearance, so that six TDRs were studied in detail. Five TDRs were formed by the connection of several small dark sticks from end to end, and the sixth TDR was formed by the merging of two thin sticks. In the later stage of the TDR evolution, five TDRs were broken down into several small dark sticks, and the sixth TDR dissipated with oscillation. During the evolution process, no obvious flow of material along the TDRs is detected.
Conclusions. We suggest that these TDRs are an observational representation of the regular aggregation of superpenumbral fibril footpoints and adjacent solar flocculus fibril footpoints at the outer boundaries of the sunspot superpenumbrae.
Evaluation of factors affecting entrepreneurship: a case of Indian women in the handicraft industry
Authors: Yadav Uma Shankar , Tripathi Ravindra , Tripathi Mano Ashish , Kumar Ashish , Mandal Mitu 
Published: August 2023

AbstractIn the current scenario, the level of interest is increasing in female entrepreneurship in the handicraft sector worldwide. So the primary purpose of this study is to discover the different constructs that influence women entrepreneurs in India as learner students or after completion of their degree, either skill degree or professional degree. Female entrepreneurship is an important feature of economic progress, particularly in developing nations, since it provides opportunities for innovation, cultural and traditional connectivity, job creation, poverty reduction, socio-economic growth, etc. However, despite its significance, this study has garnered little attention in the entrepreneurship literature. For this research, we used Survey research and convenience sampling. For data analysis, AMOS 25 software was used; where needed, we used an Excel sheet for table formation. At the same time, traditional cultural constraints have tended to study Indian women’s participation in handicraft entrepreneurship. It has been seen that most Indian female entrepreneurs are successful in their businesses. These females are engaged in banking, manufacturing, food and beverage, electronic, textile, and small industries. However, the Indian government is trying to motivate female entrepreneurs in the handicraft industry, but there is less number of women entrepreneurship in these sectors due to many factors. Just a handful has benefited through initiative, especially in the handicraft industry. Furthermore, only a few research articles have focused on the effect of essential elements. The research provides an Entrepreneurship Event Model, a Theory of Planned Behaviour, and an integrated model of the theory, which is evaluated using data from some Indian Institutions focused on entrepreneurship.
A geographical perspective on the formation of urban nightlife landscape
Authors: Liu Yi , Zhang Yifan , Zhang Xiaolin , Han Fangfei , Zhao Ying 
Published: August 2023

AbstractThe significance of nightlife and the nighttime economy has witnessed a growing prominence in the realm of urban development. The urban nightlife landscape, serving as the backdrop for urban nighttime pursuits, plays a significant role in determining nighttime consumption patterns and overall nocturnal experiences. However, there is a significant lacuna in the existing scholarship on the fundamental reasoning behind the formation of nightlife landscapes, with the primary analytical focus in earlier studies on daytime landscapes. Drawing upon a spatiotemporal geography perspective, this paper aims to uncover the underlying logic behind the various forms of urban nightlife landscapes. It seeks to identify the key factors that shape these landscapes, thus unveiling their formation mechanisms, overall typology and aesthetic characteristics. Based on the cases of four bar streets in Guangzhou, China, this study argues that the historical heritage and location advantages give rise to two developmental forces in shaping the nightlife landscape: romanticisation and commercialisation. The intertwining of these two forces results in four fundamental categories of urban nightlife landscape: ordinary leisure, gentrification, creative and nostalgic districts, each exhibiting distinct aesthetic characteristics. This paper provides insights into the formation and aesthetic mechanisms of urban nightlife landscapes, and emphasises the importance for urban planners and policymakers to take the spatial-historical context into account when formulating strategies for urban beatification initiatives.