bluuebunny/crossref_metadata_2025_split huggingface dataset:
Harnessing the power of artificial intelligence to advance cell therapy
Authors: Capponi Sara , Daniels Kyle G. 
Published: July 2023

SummaryCell therapies are powerful technologies in which human cells are reprogrammed for therapeutic applications such as killing cancer cells or replacing defective cells. The technologies underlying cell therapies are increasing in effectiveness and complexity, making rational engineering of cell therapies more difficult. Creating the next generation of cell therapies will require improved experimental approaches and predictive models. Artificial intelligence (AI) and machine learning (ML) methods have revolutionized several fields in biology including genome annotation, protein structure prediction, and enzyme design. In this review, we discuss the potential of combining experimental library screens and AI to build predictive models for the development of modular cell therapy technologies. Advances in DNA synthesis and high‐throughput screening techniques enable the construction and screening of libraries of modular cell therapy constructs. AI and ML models trained on this screening data can accelerate the development of cell therapies by generating predictive models, design rules, and improved designs.
A new DEA model for slacks‐based measure of efficiency and super‐efficiency with strongly efficient projections
Authors: Liu Peide , Xu Hongxue , Xu Ke 
Published: July 2023

AbstractMost of the existing researches for the integrated model of slack‐based measure (SBM) and SuperSBM models ignore two major problems. First, the SuperSBM model may yield weakly efficient projections such that the super‐efficiency is overestimated due to ignoring the inefficiency components. Second, in the existing integrated models, some integrated models have feasible solutions, but their scale is very large; some integrated models are very small in scale, but there may be no feasible solutions. Therefore, this paper tackles these problems and presents a modified SuperSBM (MSuperSBM) model. The MSuperSBM model can differentiate all decision‐making units and determine their strongly efficient projections simultaneously. And the actual‐efficiency scores obtained objectively discount the inefficiency components relative to the strongly efficient point, thereby they are not overestimated. In addition, the MSuperSBM model contains only necessary decision variables and constraints, which can reduce the number of required computations for large‐scale performance evaluation. Finally, through several numerical experiments, the advantages of our model in the computational results and computational scale are verified.
Scintillator‐oriented near‐infrared emitting Cs4SrI6:Yb2+, Sm2+single crystals via sensitization strategy
Authors: Wen Xuemin , Kucerkova Romana , Babin Vladimir , Prusa Petr , Kotykova Monika , Nikl Martin , Li Wen , Wang Qian , Kurosawa Shunsuke , Wu Yuntao 
Published: July 2023

AbstractIn this study, a new Cs4SrI6:Yb2+,Sm2+near‐infrared (NIR) emitting scintillator was developed using sensitization strategy. It was found that Yb2+sensitization significantly enhances the NIR radioluminescence (RL) of Sm2+, providing a new approach of designing highly emissive sensitized NIR scintillators. By studying the optical spectra and decay kinetics of Cs4SrI6:Yb2+,Sm2+, it was revealed that the energy transfer pathways involve both radiative and nonradiative processes. The gamma spectroscopy performance of Cs4SrI6:Yb2+,Sm2+single crystals was studied by using the high‐quantum‐efficiency avalanche photodiode (APD) as the readout. Our results highlight the importance of using sensitization strategy of achieving NIR emitting scintillators and demonstrate the significant potential for radiation detection applications.
Fast Ce,Ca:LuAG scintillation ceramics for HEP: Fabrication, characterization, and computation
Authors: Zhu Danyang , Chen Xiaopu , Cai Jiajia , Beitlerova Alena , Kucerkova Romana , Chewpraditkul Weerapong , Nikl Martin , Li Jiang 
Published: July 2023

AbstractHigh‐energy physics community is looking for a hard, fast, and low‐cost scintillation material, and Ce:Lu3Al5O12 (Ce:LuAG) ceramic is one of the competitive candidates. This work presents Ce,Ca:LuAG scintillation ceramics with good optical quality, and the influence of Ce and Ca concentrations on optical and scintillation properties was fully analyzed. At relatively low level of Ce concentration, the less Ca2+ content is needed to achieve a significant intensity increase in fast scintillation component while maintaining a relatively high light yield (LY). The introduction of only 0.1 at% Ca2+ could increase the LY0.5 μs/LY3.0 μs from 79.9% to 96.1% in Ce,Ca:LuAG ceramics of 0.1 at% Ce. First‐principles investigations are further performed to reveal the tuning mechanisms of the scintillation properties of LuAG by Ce and Ca codoping. We show that the Fermi level shifts down with Ca codoping, which increases the Ce4+ content and decreases the depth of the electron traps (VO), resulting to a faster decay. Moreover, the formation preference of Ca‐VO complexes over Ce‐VO leads to the suppression of the non‐radiative decay of Ce via VO. In summary, our study demonstrates the realization of the performance tuning of LuAG via Ce and Ca codoping.
‘Pretty cathartic actually’: Reflections on the attempt to reduce re‐traumatization of researchers and nurses taking part in a longitudinal interview study
Authors: Conolly Anna , Rowland Emma , Abrams Ruth , Harris Ruth , Kelly Daniel , Kent Bridie , Maben Jill 
Published: July 2023

AbstractAimTo critically evaluate the concepts of harm and re‐traumatization in the research process and to explore the ethical implications of conducting research on distressing topics using our research on the experiences of nurses working during the COVID‐19 pandemic as an exemplar.DesignLongitudinal qualitative interview study.MethodsUsing qualitative narrative interviews, we explored the impacts of the COVID‐19 pandemic on nurses' psychological well‐being in the UK.ResultsTo reduce the potential for harm to both research participants and researchers, the members of the research team were keen to establish ways to reduce the power differential between the researcher and participants. We found that our collaborative and team‐based approach, with participant autonomy and researcher reflexivity embedded into the research framework, enabled the sensitive generation of data.ConclusionReduction of potential harm for both participants and researchers in the generation of at times highly distressing data with a traumatized population was achieved through a respectful, honest and empathetic approach within a team that met frequently for reflection.ImpactThe research participants were not harmed by our research, instead they expressed gratitude at being given space and time to tell their stories in a supportive environment. Our work advances nursing knowledge through accentuating the value of giving autonomy to research participants to control their stories whilst working within a supportive research team with emphasis placed on reflexivity and debriefing.Patient and Public ContributionNurses working clinically during COVID‐19 were involved in the development of this study. Nurse participants were given autonomy over how and when they participated in the research process.
The relationship between mental health continuum and care dependency in individuals with chronic obstructive pulmonary disease: A cross‐sectional study
Authors: Akay Berna , Bozkurt Canan , Bulut Hülya 
Published: July 2023

AbstractAimTo examine the relationship between mental health continuum and care dependence of hospitalized patients, who were diagnosed with chronic obstructive pulmonary disease (COPD).DesignDescriptive, cross‐sectional study.MethodsThe data were obtained from 448 inpatients diagnosed with COPD, who were treated in clinics, by utilizing questionnaires and face‐to‐face interviews between November 2021 and February 2022. The Mental Health Continuum Short Form and Care Dependency Scale were used by the researchers with the sociodemographic and clinical characteristics form created in line with the literature. The data were analysed using the SPSS 23.0 software.ResultsIt was determined that a moderately significant positive relationship between mental health continuum and care dependency. In addition, the patient's perception of own health, disease stage and severity of dyspnoea were also found to be associated with mental health and care dependency. Gender, marital status, employment status and income level were found to be associated with mental health continuum, but not with care dependency. Advanced age, low educational level, alcohol consumption, antidepressant use and comorbidities were found to be associated with both care dependency and mental health continuum.ConclusionIndividuals with COPD who have low mental health, poor health perception, high disease stage and dyspnoea severity have high care dependency.ImpactIn this study, it was revealed that the level of mental health continuum was significantly associated with care dependency in individuals with COPD; in addition, the individual's perception of poor health, disease stage and dyspnoea severity were other factors associated with care dependency. It is important for nurses working with individuals with COPD to evaluate the mental health of individuals with poor health perception, high disease stage and dyspnoea severity and to plan appropriate interventions to reduce care dependency.Patient or Public ContributionNo patient or public contribution was required in the design, conduct, analysis or interpretation of this study. Patients/public members only contributed to data collection. Data were obtained from patients hospitalized in the chest diseases clinic of a training and research hospital.
The origin and spread of the southern black ant, a widely distributed leaf‐cutting ant
Authors: Sánchez‐Restrepo Andrés F. , Confalonieri Viviana A. , Calcaterra Luis A. 
Published: July 2023

AbstractAimThe existence of past connections between different regions through corridors has influenced the diversification of the biota in South America. Evidence of such connections in southern South America is scarce and poorly understood. As a model to analyse the existence of these corridors we study the evolutionary history of a widely distributed leaf‐cutting ant by inferring its origin, historical demographic and dispersal processes, and explore for evidence that relates its evolutionary history to geoclimatic events.LocationSouthern South America.TaxonSouthern black ant (Acromyrmex lobicornis).MethodsA total of 215 samples were obtained from Argentina, Uruguay and Bolivia. A time‐calibrated phylogenetic tree, using a fossilised birth–death process model, was obtained using one mitochondrial and four nuclear molecular markers. Historical demographic processes were inferred using coalescence‐based methodologies. A Bayesian continuous phylogeographical diffusion model was used to estimate the geographical origin and infer its spread routes.ResultsA. lobicornis has two main occurrence areas: one goes through the Arid diagonal in Argentina up to Bolivia, and the other goes from central Uruguay up to southern Brazil. Both areas are connected by scattered populations distributed along the Espinal ecoregion in Argentina. The estimated crown age is ~1.2 Ma (early Pleistocene). The origin of the species was located between the High Monte and Dry Chaco ecoregions, from where it dispersed along the Arid diagonal and towards the east into the Uruguayan Savannas through the Espinal.Main ConclusionsThe Espinal has an important role as a bridge for the dispersion and posterior maintaining of the genetic flow between populations of A. lobicornis, a corridor that could have been also used by other species. As opposed to the previous hypothesis that postulated its origin in a humid subtropical region, this study provides novel evidence placing the origin of A. lobicornis in an arid subtropical region.
Angiotensin‐converting enzyme inhibitor induced cough compared with placebo, and other antihypertensives: A systematic review, and network meta‐analysis
Authors: Hu Yiyun , Liang Ling , Liu Shuang , Kung Janice Y. , Banh Hoan Linh 
Published: July 2023

AbstractStudies have shown that angiotensin converting enzyme inhibitors (ACEIs) are superior in primary and secondary prevention for cardiac mortality and morbidity to angiotensin receptor blocker (ARBs). One of the common side effects from ACEI is dry cough. The aims of this systematic review, and network meta‐analysis are to rank the risk of cough induced by different ACEIs and between ACEI and placebo, ARB or calcium channel blockers (CCB). We performed a systematic review, and network meta‐analysis of randomized controlled trials to rank the risk of cough induced by each ACEI and between ACEI and placebo, ARB or CCB. A total of 135 RCTs with 45,420 patients treated with eleven ACEIs were included in the analyses. The pooled estimated relative risk (RR) between ACEI and placebo was 2.21 (95% CI: 2.05–2.39). ACEI had more incidences of cough than ARB (RR 3.2; 95% CI: 2.91, 3.51), and pooled estimated of RR between ACEI and CCB was 5.30 (95% CI: 4.32–6.50) Moexipril ranked as number one for inducing cough (SUCRA 80.4%) and spirapril ranked the least (SUCRA 12.3%). The order for the rest of the ACEIs are as follows: ramipril (SUCRA 76.4%), fosinopril (SUCRA 72.5%), lisinopril (SUCRA 64.7%), benazepril (SUCRA 58.6%), quinapril (SUCRA 56.5%), perindopril (SUCRA 54.1%), enalapril (SUCRA 49.7%), trandolapril (SUCRA 44.6%) and, captopril (SUCRA 13.7%). All ACEI has the similar risk of developing a cough. ACEI should be avoided in patients who have risk of developing cough, and an ARB or CCB is an alternative based on the patient's comorbidity.
Over‐expression of Dyrk1A affects bleeding by modulating plasma fibronectin and fibrinogen level in mice
Authors: Postic Guillaume , Solarz Jean , Loubière Cécile , Kandiah Janany , Sawmynaden Jaysen , Adam Frederic , Vilaire Marie , Léger Thibaut , Camadro Jean‐Michel , Victorino Daniella Balduino , Potier Marie‐Claude , Bun Eric , Moroy Gautier , Kauskot Alexandre , Christophe Olivier , Janel Nathalie 
Published: July 2023

AbstractDown syndrome is the most common chromosomal abnormality in humans. Patients with Down syndrome have hematologic disorders, including mild to moderate thrombocytopenia. In case of Down syndrome, thrombocytopenia is not associated with bleeding, and it remains poorly characterized regarding molecular mechanisms. We investigated the effects of overexpression of Dyrk1A, an important factor contributing to some major Down syndrome phenotypes, on platelet number and bleeding in mice. Mice overexpressing Dyrk1A have a decrease in platelet number by 20%. However, bleeding time was found to be reduced by 50%. The thrombocytopenia and the decreased bleeding time observed were not associated to an abnormal platelet receptors expression, to a defect of platelet activation by ADP, thrombin or convulxin, to the presence of activated platelets in the circulation or to an abnormal half‐life of the platelets. To propose molecular mechanisms explaining this discrepancy, we performed a network analysis of Dyrk1A interactome and demonstrated that Dyrk1A, fibronectin and fibrinogen interact indirectly through two distinct clusters of proteins. Moreover, in mice overexpressing Dyrk1A, increased plasma fibronectin and fibrinogen levels were found, linked to an increase of the hepatic fibrinogen production. Our results indicate that overexpression of Dyrk1A in mice induces decreased bleeding consistent with increased plasma fibronectin and fibrinogen levels, revealing a new role of Dyrk1A depending on its indirect interaction with these two proteins.
Using Response Time in Multidimensional Computerized Adaptive Testing
Authors: He Yinhong , Qi Yuanyuan 
Published: July 2023

AbstractIn multidimensional computerized adaptive testing (MCAT), item selection strategies are generally constructed based on responses, and they do not consider the response times required by items. This study constructed two new criteria (referred to as DT‐inc and DT) for MCAT item selection by utilizing information from response times. The new designs maximize the amount of information per unit time. Furthermore, these two new designs were extended to the DTS‐inc and DTS designs to efficiently estimate intentional abilities. Moreover, the EAP method for ability estimation was also equipped with response time. The performances of the response‐time‐based EAP (RT‐based EAP) and the new designs were evaluated in simulation and empirical studies. The results showed that the RT‐based EAP significantly improved the ability estimation precision compared with the EAP without using response time, and the new designs dramatically saved testing times for examinees with a small sacrifice of ability estimation precision and item pool usage.
Courtship behavior in the knife livebearer Alfaro cultratus (Cyprinodontiformes: Poeciliidae)
Authors: Garita‐Alvarado Carlos A. 
Published: July 2023

AbstractThe mating behavior of the knife livebearer Alfaro cultratus is described in detail. During “rubbing,” the male swims to a position above the female and gently moves down repeatedly touching the dorsal part of female head with the pelvic fin tips. This courtship behavior constitutes the first report of a pelvic fin male–female contact during mating in poecilids. Based on preliminary evidence, I propose that a sensory bias mechanism could mediate the evolution of signal design/mate choice in this species, which should be tested in further studies.
Data implementation matters: Effect of software choice and LCI database evolution on a comparative LCA study of permanent magnets
Authors: Miranda Xicotencatl Brenda , Kleijn René , van Nielen Sander , Donati Franco , Sprecher Benjamin , Tukker Arnold 
Published: July 2023

AbstractLife cycle assessment (LCA) databases and software evolve. We analyzed to which extent software and evolving life cycle inventory databases affect the comparison of technology alternatives, using a comparative LCA on permanent magnets as a case study, with two selected software tools: CMLCA and Brightway LCA. We migrated the system models from the CMLCA to Brightway LCA software and alternated between the ecoinvent database versions 2.2 and 3.1 to 3.6 in the system background. When using ecoinvent v3.6 instead of v2.2, the change of the indicator results ranged from to 283%. The evolution of the ecoinvent database impacted the absolute amounts of the characterized results and the relative performance between alternatives. The impact category with the highest variability was ionizing radiation, which even showed a ranking inversion with ecoinvent v3.4. In contrast, the impact of using CMLCA or Brightway was negligible because the same data and modeling assumptions caused percentage differences below 0.4%. During the semi‐automated data migration to Brightway, we identified 23 environmental flows in the CMLCA model that were not paired with their corresponding characterization factors in the published study of reference. This error had led to an underestimation of 63% in the photochemical oxidation indicator of one of the alternatives. This underestimation relates to an interoperability issue regarding the nomenclature of environmental flows in software alternatives and is a matter of data implementation rather than an issue intrinsic to the selected software. Finally, we identified improvement opportunities for the transparency and reusability of LCA models. This article met the requirements for a Gold‐Gold JIE data openness badge described at http://jie.click/badges.
Quantifying a virtual water metabolic network of the Metropolitan District of Quito, Ecuador using ecological network methods
Authors: Rosales Francisco Orlando , Fath Brian D. , Llerena Grace Yolanda 
Published: July 2023

AbstractCurrent human population is mostly located in urban areas making cities the center of attention in terms of achieving sustainability goals. Evidence shows that ecosystems have evolved over time toward a balanced configuration between resource efficiency and functional redundancy. For this reason, they are exemplary models to follow in terms of sustainability. Here, we apply similar ecological network‐based methods to study the virtual water metabolic network (VWMN) of the Metropolitan District of Quito. The VWMN was obtained using novel bottom‐up, survey‐based methods to generate the urban metabolic network. We compare the VWMN results with those previously obtained from ecological food webs, to learn if there are insights about the sustainability of urban metabolic processes. We conclude that VWMN does not exhibit characteristics observed in sustainable ecological networks because this socioeconomic network exhibits higher levels of path redundancy. Urban metabolism studies are gaining in popularity as a research tool aimed at informing resource management and this is one of the first covering a city in the Global South and using a bottom‐up survey method.
EDITOR SPOTLIGHT: Interview with Brain Proteostasis Special Issue Guest Editor Mychael Lourenco
Authors:   JNC Editorial Office, Kwan Kim H. , Lourenco Mychael V. 
Published: July 2023

AbstractMychael Lourenco is an Assistant Professor of Neuroscience at the Institute of Medical Biochemistry Leopoldo de Meis, Federal University of Rio de Janeiro. Research in his lab focusses on understanding the molecular mechanisms underlying cognitive impairment in neurodegeneration and his research on Alzheimer's disease has been recognized by many awards both in Brazil and internationally. He serves as a Reviews Editor for the Journal of Neurochemistry and led this special issue on Brain Proteostasis as a Guest Editor. Here we interviewed him to hear his thoughts on the future of neuroscience and on career development and training.image
Somatosensory profiling of patients undergoing alcohol withdrawal: Do neuropathic pain and sensory loss represent a problem?
Authors: Fernandez Aurore , Graf Guillaume , Lasserre Aurélie , Daeppen Jean‐Bernard , Chu Sin Chung Paul , Berna Chantal , Suter Marc R. 
Published: July 2023

AbstractIntroductionChronic heavy alcohol use is known to cause neurological complications such as peripheral neuropathy. Concerning the pathophysiology, few sural nerve and skin biopsy studies showed that small fibers might be selectively vulnerable to degeneration in alcohol‐related peripheral neuropathy. Pain has rarely been properly evaluated in this pathology. The present study aims at assessing pain intensity, potential neuropathic characteristics as well as the functionality of both small and large nerve sensitive fibers.MethodsIn this observational study, 27 consecutive adult patients, hospitalized for alcohol withdrawal and 13 healthy controls were recruited. All the participants underwent a quantitative sensory testing (QST) according to the standardized protocol of the German Research Network Neuropathic Pain, a neurological examination and filled standardized questionnaires assessing alcohol consumption and dependence as well as pain characteristics and psychological comorbidities.ResultsNearly half of the patients (13/27) reported pain. Yet, pain intensity was weak, leading to a low interference with daily life, and its characteristics did not support a neuropathic component. A functional impairment of small nerve fibers was frequently described, with thermal hypoesthesia observed in 52% of patients. Patients with a higher alcohol consumption over the last 2 years showed a greater impairment of small fiber function.DiscussionPatients report pain but it is however unlikely to be caused by peripheral neuropathy given the non‐length‐dependent distribution and the absence of neuropathic pain features. Chronic pain in AUD deserves to be better evaluated and managed as it represents an opportunity to improve long‐term clinical outcomes, potentially participating to relapse prevention.