bluuebunny/crossref_metadata_2025_split huggingface dataset:
TIPS-17 A FIRST-IN-HUMAN FEASIBILITY STUDY TO EVALUATE THE SAFETY OF SELECTIVE INTRA-ARTERIAL YTTRIUM-90 MICROSPHERE TREATMENT IN PATIENTS WITH RECURRENT GLIOBLASTOMA (THE FRONTIER TRIAL)
Authors: Mouli Samdeep , Goyal Piyush , Tate Matthew , Dixit Karan , Primdahl Ditte , Boockvar John , Quinones-Hinojosa, Alfredo , Weiss Cliffword , Butowski Nicholas , Dreher Matthew , Stupp Roger , Salem Riad 
Published: August 2023

Abstract
BACKGROUND: Glioblastoma (GBM) is the most aggressive primary brain tumor that virtually always recurs with no established standard therapy at recurrence. Median survival after recurrence is 7-12 months. Selective internal radiation therapy (SIRT) with Yttrium-90 (Y90) glass microspheres (TheraSphere™, Boston Scientific, Marlborough, MA) is an FDA approved standard treatment for hepatocellular carcinoma, and represents a novel strategy to treat regionally localized brain tumors. We are conducting a first-in-human clinical trial (under IDE) using Y90 microspheres modified to treat tumors in the brain. The goal of selectively delivering Y90 intra-arterially is to achieve higher tumoral absorbed doses while limiting non-target exposure. DESIGN: The primary objective is to evaluate the safety of Y90 microspheres treatment. Target enrollment is 12 patients at 5 participating medical centers. Key inclusion criteria include: 1st or 2nd recurrence of GBM , size 1-5cm, located in the non-dominant hemisphere in a non-eloquent region, accessible neurovascular anatomy for single intra-arterial treatment based on a diagnostic cerebral angiogram. After consent, patients will undergo screening angiography and imaging that be reviewed by the trial steering committee to determine treatment suitability. Treatment consists of Y90 microspheres administered intra-arterially to deliver 40Gy ± 10% to the treatment volume. Post-administration Y90 PET and MRI images allow assessment of dose distribution and acute safety. Following overnight admission, patients will be followed as outpatients weekly x 4, and then monthly up to month 6. Primary endpoints include treatment-related limiting toxicities, dose limiting toxicity defined as non-hematological toxicities ≥ grade 3, CNS toxicity ≥ grade 3 (eg. symptomatic ischemia or edema) related to non-target embolization, occurring through 30 days post procedure. Secondary endpoints include: treatment-related serious adverse events, change in post-treatment neurological function, technical success, objective response rate, progression-free survival, and overall survival.
The study is registered with clinicaltrials.gov, number: NCT05303467.
Zoonotic Transmission of Vaccine-Derived Bordetella bronchiseptica
Authors: Kraai Imke , Knoester Marjolein , Bathoorn Erik , Bakker Martijn , Nijland Marcel 
Published: August 2023

Abstract
We describe a unique case of a 43-year-old-female with a Bordetella bronchiseptica infection caused by zoonotic transmission following vaccination of her dog. With this report, we want to raise awareness of potential zoonotic transmission of live attenuated vaccines from animals to patients with impaired immunity.
Reproductive roles as likely drivers of sexual dimorphism in New Zealand’s endangered mountain parrot, the Kea
Authors: McLean Lydia R W , Horton Travis W , Robertson Bruce C , Robertson Fiona , Greer Amanda L , Nelson Ximena J 
Published: August 2023

Abstract
New Zealand’s endangered mountain parrot, the Kea (Nestor notabilis), exhibits moderate male-biased sexual size dimorphism in linear body measurements (~5%) and a pronounced dimorphism in bill size (12–14%). Using stable isotope analyses of carbon and nitrogen in Kea feathers and blood sampled from a significant portion (~10%) of the extant population, we determined that Kea bill dimorphism may be an ecologically selected trait that enhances male Kea’s ability to forage at a higher trophic level in order to provision females and offspring during nesting. Sexual dimorphism can arise through sexual selection, ecological drivers, or a combination of both. Ecological selection is associated with foraging niche divergence between the sexes to reduce inter-sexual competition or due to differing dietary needs associated with reproductive role. Despite the widespread occurrence of sexual dimorphism throughout the animal kingdom, empirical evidence for ecological causation is rare. We conducted the first molecular confirmation of sexual size dimorphism in Kea. We then employed Bayesian mixing models to explore potential correlations between diet and bill size to determine whether the dimorphism is linked to diet partitioning throughout all age classes (fledgling, juvenile, subadult, and adult). Female Kea foraged at a consistent, relatively low, trophic level throughout their lifetime, whereas male trophic level increased with age to a maximum at subadult stage, prior to breeding for the first time—a time in which males may have been actively learning extractive foraging techniques associated with a high protein diet. Adult males foraged at a high trophic level relative to all groups except subadult males. As males provision females on the nest, which in turn provision young, these results highlight that the evolution of morphology and reproductive output may be linked in circuitous ways.
PINOID and PIN-FORMED Paralogous Genes Are Required for Leaf Morphogenesis in Rice
Authors: Liu Jiajun , Shi Xi’an , Zhong Tianhui , Jie Wanrong , Xu Ruihan , Ding Yanfeng , Ding Chengqiang 
Published: August 2023

Abstract
Auxin plays an essential role in modulating leaf development. However, its role in leaf development in rice (Oryza sativa L.) remains largely unknown. In this study, we found that PINOID (OsPID) and two Sister-of-PIN1s, termed PIN-FORMED1c (OsPIN1c) and OsPIN1d, are necessary for rice leaf development. The ospin1c ospin1d null mutant lines presented severe defects in leaf morphogenesis, including drooping and semi-drooping blades, an abnormally thickened sheath and lamina joint, and fused leaves with absent ligules and auricles. Loss-of-function ospid mutants displayed generally similar leaf morphology but lacked leaf fusion. Interestingly, misshaped leaf genesis displayed a preference for being ipsilateral. In addition, OsPIN1c and OsPID were commonly localized in the initiating leaf primordia. Furthermore, accompanied by the more severe organ morphogenesis in the ospin1c ospin1d ospid triple mutant, RNA sequencing analysis revealed that many genes essential for leaf development have an altered expression level. Together, this study furthers our understanding of the role auxin transport plays during leaf development in monocot rice.
Social Media Effects on Public Trust in the European Union
Authors: Kiratli Osman Sabri 
Published: August 2023

Abstract
This paper scrutinizes the effect of social media use on institutional trust in the European Union (EU) among European citizens. Fixed-effects regression models on data from the Eurobarometer survey conducted in 2019, the year of the most recent European Parliament (EP) elections, demonstrate that higher social media use is associated with lower trust in the EU. More importantly, social media usage habits exert particularly detrimental effects in regions with wider and faster internet connections. In such high-information environments, those who more frequently use online social networks, tend to trust those networks, and receive information on EU affairs from these networks have less faith in the EU compared to those in regions with lower-quality internet access. In contrast, in regions with lower broadband access, receiving EU information from social media fosters political trust.
Evolution of monoclonal gammopathy of undetermined significance in patients treated with JAK inhibitors for rheumatic diseases: data from the MAJIK-SFR registry
Authors: Faganello Déborah , Bertrand Anne , Meunier Pauline , Avouac Jérôme , Toussirot Eric , Coury Fabienne , Seror Raphaele , Le Mélédo Guillaume , Germain Vincent , Dellal Azedinne , Shima Ditmar , Hulin Cyrille , Prati Clément , Schaeverbeke Thierry , Richez Christophe , Truchetet Marie-Elise , Kostine Marie 
Published: August 2023

Abstract

Objective
Monoclonal gammopathy of undetermined significance (MGUS) is common, but there are scarce data regarding the effect of DMARDs on this premalignant condition. We aimed to evaluate the impact of JAK inhibitors (JAKis) on MGUS when initiated for an active rheumatic disease.

Methods
Patients with monoclonal abnormality prior to JAKi initiation for an active rheumatic disease were identified through the MAJIK-SFR Registry, a French multicentre prospective study. Clinical and biological data were collected using a standardized case report form.

Results
Twenty patients were identified with a mean age of 65 years and a diagnosis of RA (n = 15), PsA (n = 3), and axial SpA (n = 2). The JAKi prescribed was baricitinib (n = 9), tofacitinib (n = 6) or upadacitinib (n = 5), with a mean duration of 15.5 months. Seventeen patients had individualized serum monoclonal protein (IgG kappa n = 9; IgG lambda n = 4; IgM kappa n = 3; IgA lambda n = 1) ranging from 0.16 to 2.3 g/dl, and three patients did not have an initial measurable spike but they had a positive serum immunofixation. With a follow-up of 4–28 months, the serum monoclonal protein level decreased in 8 of 17 patients (47%), remained stable in 8 patients (47%) and increased in 1 patient (6%). The maximal decrease observed was an initial IgG kappa of 2.3 g/dl, decreasing to 0.2 g/dl at month 14.

Conclusion
This study provides reassuring and promising data on MGUS evolution in patients treated with JAKis for rheumatic diseases, which may guide the choice of treatment in patients with both conditions.
Uncovering the Heterogeneity of Cardiac Lin−KIT+ Cells: A scRNA-seq Study on the Identification of Subpopulations
Authors: Shen Yan , Kim Il-Man , Tang Yaoliang 
Published: August 2023

Abstract
The reparative potential of cardiac Lin–KIT+ (KIT) cells is influenced by their population, but identifying their markers is challenging due to changes in phenotype during in vitro culture. Resolving this issue requires uncovering cell heterogeneity and discovering new subpopulations. Single-cell RNA sequencing (scRNA-seq) can identify KIT cell subpopulations, their markers, and signaling pathways. We used 10× genomic scRNA-seq to analyze cardiac-derived cells from adult mice and found 3 primary KIT cell populations: KIT1, characterized by high-KIT expression (KITHI), represents a population of cardiac endothelial cells; KIT2, which has low-KIT expression (KITLO), expresses transcription factors such as KLF4, MYC, and GATA6, as well as genes involved in the regulation of angiogenic cytokines; KIT3, with moderate KIT expression (KITMOD), expresses the cardiac transcription factor MEF2C and mesenchymal cell markers such as ENG. Cell-cell communication network analysis predicted the presence of the 3 KIT clusters as signal senders and receivers, including VEGF, CXCL, and BMP signaling. Metabolic analysis showed that KIT1 has the low activity of glycolysis and oxidative phosphorylation (OXPHOS), KIT2 has high glycolytic activity, and KIT3 has high OXPHOS and fatty acid degradation activity, indicating distinct metabolic adaptations of the 3 KIT populations. Through the systemic infusion of KIT1 cells in a mouse model of myocardial infarction, we observed their involvement in promoting the formation of new micro-vessels. In addition, in vitro spheroid culture experiments demonstrated the cardiac differentiation capacity of KIT2 cells.
Disability Justice and the Americans with Disabilities Act: An Opportunity for Social Work
Authors: Muster Caroline L 
Published: August 2023

AbstractAccording to the Centers for Disease Control and Prevention, over 61 million Americans have a disability, which translates to about 26 percent of the national population. The most common types of disability are physical (13.7 percent), or those that impact mobility, and intellectual (10.8 percent), or those related to cognitive processing. The Bureau of Justice Statistics has reported that 32 percent of people in state prisons and 40 percent of people in county jails have at least one disability, rates that demonstrate alarming disproportionality. Yet the history of the disability rights movement, the impact of the Americans with Disabilities Act for people with disabilities who are involved with the criminal justice system, and the implications of disability justice and critical disability theory for the field of social work are not well understood. The purpose of this article is to review these under-recognized topics and offer recommendations for addressing this neglected area of social work education, research, policy, and practice.
Interleukin-17A Promotes Proliferation and Osteogenic Differentiation of Human Ligamentum Flavum Cells Through Regulation of β-Catenin Signaling
Authors: Lin Jialiang , Jiang Shuai , Xiang Qian , Zhao Yongzhao , Wang Longjie , Fan Dongwei , Zhong Woquan , Sun Chuiguo , Chen Zhongqiang , Li Weishi 
Published: August 2023

Study Design.
A basic experimental study.

Objective.
To elucidate the role and mechanism of interleukin (IL)-17A in thoracic ossification of the ligamentum flavum (TOLF).

Summary of Background Data.
TOLF is characterized by the replacement of the thoracic ligamentum flavum with ossified tissue and is one of the leading causes of thoracic spinal stenosis. IL-17A is an important member of the IL-17 family that has received widespread attention for its key contributions to the regulation of bone metabolism and heterotopic ossification. However, it is unclear whether IL-17A is involved in TOLF.

Materials and Methods.
Cell counting kit‐8 assay and 5-ethynyl-2’-deoxyuridine staining were performed to assess the proliferation of ligamentum flavum cells (LFCs). Alkaline phosphatase activity assay, Alizarin red staining, and protein level expression of osteogenic-related genes were used to evaluate the osteogenic differentiation potential of LFCs. The effect of IL-17A on the proliferation and osteogenic differentiation of LFCs was further assessed after silencing β-catenin by transfection with small interfering RNA. In addition, the possible source of IL-17A was further demonstrated by coculture assays of T helper 17 (Th17) cells with LFCs. Student t test was used for comparisons between groups, and the one-way analysis of variance, followed by the Tukey post hoc test, was used for comparison of more than two groups.

Results.
IL-17A was elevated in TOLF tissue compared with normal ligamentum flavum. IL-17A stimulation promoted the proliferation and osteogenic differentiation of LFCs derived from patients with TOLF. We found that IL-17A promoted the proliferation and osteogenic differentiation of LFCs by regulating the β-catenin signaling. Coculture of Th17 cells with LFCs enhanced β-catenin signaling-mediated proliferation and osteogenic differentiation of LFCs. However, these effects were markedly attenuated after the neutralization of IL-17A.

Conclusions.
This is the first work we are aware of to highlight the importance of IL-17A in TOLF. IL-17A secreted by Th17 cells in the ligamentum flavum may be involved in the ossification of the microenvironment by regulating β-catenin signaling to promote the proliferation and osteogenic differentiation of LFCs.
The Plastic Surgery In-service Training Examination: An In-depth Reference Analysis
Authors: Meaike Jesse D. , Asaad Malke , Cantwell Sean , Elmorsi Rami , Jabal Mohamed Sobhi , Moran Steven L. 
Published: August 2023

Background:
The goal of this study was to characterize the references provided as supporting evidence of the Plastic Surgery In-service Training Examination (PSITE) syllabi, including those on the novel “core surgical principles” section.

Methods:
We analyzed the references from five consecutive PSITE Examination syllabi (2016–2020). We collected the following information from each question: question section, total number of references, and source of publication of each reference.

Results:
We analyzed 1250 questions and 3436 references. Plastic and Reconstruction Surgery was overall the most frequently referenced journal followed by Journal of Hand Surgery (American Volume) and Annals of Plastic Surgery. The most commonly referenced textbooks were Plastic Surgery (by Neligan), Green’s Operative Hand Surgery, and Grabb and Smith’s Plastic Surgery. Regarding the “core surgical principles” section, Plastic and Reconstruction Surgery remained the most frequently cited journal, followed by the Journal of the American Medical Association, New England Journal of Medicine, Annals, and Aesthetic Surgery Journal. “Core surgical principles” contained the largest number of unique journals (n = 209) among all test sections. Within the “core” section, Statistics in Medicine was the most frequently referenced textbook followed by Grabb and Smith’s Plastic Surgery.

Conclusions:
The main plastic surgery texts and literature were used to support approximately half of the answers within the “core surgical principles” section. The references within this section originated from the largest number of different journals, thus highlighting the breadth and variety of this content and the challenges in preparing for this section.
Risk Factors for Prolonged Opioid Consumption in Lower Extremity Amputees
Authors: Park Rachel H. , Liston Jared M. , Samuel Ankhita R. , Forster Grace L. , DeGeorge Brent R. 
Published: August 2023

Background:
Extremity amputation is a common procedure performed to treat a variety of different problems and affects quality of life in a number of ways. In addition to acute postoperative pain, amputations have been shown to cause chronic pain that is often neuropathic in many amputees. This study sought to better characterize the role of opioids in postoperative pain control in lower extremity amputees.

Methods:
Patients who underwent lower extremity amputation between 2010 and 2018 were identified in a national insurance-claims database using ICD-9, ICD-10, and CPT codes. Patient demographics, comorbidities, perioperative opioid use, and prolonged postoperative opioid use were then determined for both groups. Descriptive statistics and logistic regression analysis were utilized to evaluate the association of patient-related risk factors and neuropathic pain conditions with perioperative and prolonged postoperative opioid use.

Results:
In total, 2247 opioid-naive lower extremity amputees were identified. An estimated 54.7% of patients utilized opioids in the perioperative period, and 44.6% were found to have prolonged opioid use. Younger age (ages 40–50 versus older), history of chronic pain, migraines, lower back pain, Charlson Comorbidity Index greater than 1, preoperative benzodiazepine, muscle relaxant, anticonvulsant, and antidepressant use were all significantly related to prolonged postoperative opioid use.

Conclusions:
Prolonged postoperative opioid use is a problem that affects nearly half of lower extremity amputees and seems to be significantly related to the preoperative use of benzodiazepines, muscle relaxants, anticonvulsants, and antidepressants. Further research into the diagnosis and treatment of postamputation neuropathic pain is needed to prevent reliance on opioids in this patient population.
Reliability of Perforator-based UPM Flap for Coverage of Little Finger and Dorsal Hand Defect
Authors: Estawrow Mina A. , Gad Ahmed M. 
Published: August 2023

Background:
There are different approaches for reconstruction of little finger and dorsal hand defects. The ulnar parametacarpal flap, first introduced by Backhach et al in 1995, is considered a good option for reconstructing such defects. In this study, we elevated this flap on one perforator and applied it as a propeller flap. We then discussed the reliability of this flap and which perforator (the proximal or the distal one) is more reliable.

Methods:
This study was carried out on 20 patients with different little finger and dorsal hand defects between June 2017 and March 2019. All defects were covered by perforator-based ulnar parametacarpal flaps. Ten flaps were based on the proximal perforator, whereas the other 10 were based on the distal perforator.

Results:
With a period of follow-up ranging from 6 months to 1 year, all flaps that were raised on the proximal perforator survived completely, whereas two of 10 flaps raised on the distal perforator showed venous congestion and also one flap showed partial necrosis of the distal one-third due to ischemia.

Conclusions:
The perforator based ulnar parametacarpal flap is a reliable option for reconstruction of little finger and dorsal hand defects. It is more reliable when it is raised on the proximal perforator rather than on the distal one.
Posterior Tibial Artery Perforator V-Y Advancement Flap for Small–Medium Size Lower Limb Defects
Authors: Almishal Obaid , Bin Mahmoud Asmaa Z. , Alshomer Feras M. 
Published: August 2023

Background:
The posterior tibial artery perforator flap has been described as a good option for small to moderate lower extremity defects with consistent anatomy and caliber. Different geometrical designs are found in the literature for posterior tibial artery perforator flaps and are mostly executed as propeller, peninsular, and island flaps. Upon literature review, V-Y advancement flaps were not commonly used, despite the clear design, persistent anatomy, and straight execution. Our aim was to report our case series to present the validity of such design and the success of reconstruction.

Method:
Over 1 year, three cases were reconstructed successfully with posterior tibial artery perforator flaps with V-Y advancement design. Clinical evaluation was done for all patients as well as follow-up in the outpatient clinic until complete healing of the wounds was achieved. Multiple modifications were done intraoperatively to enhance flap reach and minimize the complications, including designing V-Y advancement flaps larger than the defect, careful perforator dissection, and finally, strict postoperative course.

Results:
All three cases healed completely with no complications. The average follow-up time in the clinic was 3 months.

Conclusions:
Posterior tibial artery perforator flap with V-Y advancement design is a viable option for reconstructing medium sized lower limb defects, but requires careful design and execution. The suggested steps will increase the survival of the flap and reconstruct the defect successfully.