bluuebunny/crossref_metadata_2025_split huggingface dataset:
Endoscopic Extended Transsphenoidal Surgery Aiming for Radical Resection of Skull Base Tumors Involving Cavernous Sinus: Assessment of Resectability and Risks of Complications
Authors: Hanakita Shunya , Shin Masahiro , Hasegawa Hirotaka , Shojima Masaaki , Ohara Kenta , Shinya Yuki , Kawashima Mariko , Kondo Kenji , Saito Nobuhito 
Published: June 2023

BACKGROUND AND OBJECTIVES:
Surgical resection of tumors invading the cavernous sinus (CS) still shows therapeutic challenges. For “nonadenomatous” skull base tumors invading in CS, there were only a few reports showing the outcomes of radical resection. Therefore, the outcomes of endoscopic transsphenoidal surgery (ETS) aiming for radical resection thus remain largely unknown regarding resectability and functional results of the cranial nerves.

METHODS:
We performed ETS aiming for radical resection in 35 skull base tumors involving CS (17 chondrosarcomas, 12 chordomas, 3 meningiomas, and 3 trigeminal schwannomas; median follow-up 36.5 months ranging from 12 to 91 months). Gross total resection (GTR) is attempted in all the cases for real-time findings from electrophysiological monitoring of the cranial nerves. When the tumor was strongly adherent to the cranial nerves or internal carotid artery, maximum volume reduction of the tumor was attempted.

RESULTS:
GTR was achieved in 28 patients (80.0%), subtotal resection in 3 (8.6%), and partial resection in 4 (11.4%). One patient experienced internal carotid artery injury during surgery. After ETS, 15 patients showed symptom improvement (51.7% in all 29 patients with preoperative cranial nerve symptoms, CNS). Four (11.4%) transiently developed abducens nerve palsy, and one required repair surgery for cerebrospinal leakage. In univariate analyses, extension to the lateral compartment of CS (P = .04) was significantly associated with reduced achievement of GTR. Previous transcranial surgery was associated with reduced possibility of improvement and worsening in CNS. Eleven patients underwent stereotactic radiosurgery, at a median of 12 months after ETS. 32 patients (91.4%) did not show recurrence at the final follow-up.

CONCLUSION:
ETS can achieve sufficient surgical resection in most of the patients, with acceptable neurological complications. For patients with CNS, ETS may offer the opportunity for improving CNS. We should also always prioritize avoidance of critical situations by preventing internal carotid artery injury.
Evaluation of Serial Intra-Arterial Indocyanine Green Videoangiography in the Surgical Treatment of Cranial and Craniocervical Junction Arteriovenous Fistulae: A Case Series
Authors: Yamaguchi Izumi , Kanematsu Yasuhisa , Shimada Kenji , Yamamoto Nobuaki , Korai Masaaki , Miyake Kazuhisa , Miyamoto Takeshi , Sogabe Shu , Shikata Eiji , Ishihara Manabu , Yamamoto Yuki , Kuroda Kazutaka , Takagi Yasushi 
Published: June 2023

BACKGROUND AND OBJECTIVES:
Intravenous indocyanine green (IV-ICG) videoangiography is commonly performed to detect blood flow in the microscopic view. However, intra-arterial ICG (IA-ICG) videoangiography provides high-contrast imaging, repeatability within a short period of time, and clear-cut separation of the arterial and venous phases compared with IV-ICG. These features are useful for detecting retrograde venous drainage (RVD) and shunt occlusion in arteriovenous fistulae (AVF) surgery. This study aimed to investigate whether IA-ICG videoangiography can be repeatable within a short period of time and be useful for detecting RVD and shunt occlusion in cranial- and craniocervical junction (CCJ)-AVF surgery.

METHODS:
Between January 2012 and December 2022, 50 patients were treated with endovascular or surgical intervention for cranial- and CCJ-AVF at Tokushima University Hospital. Of these, 5 patients (6 lesions) underwent open surgery with IA-ICG videoangiography in a hybrid operating room. We analyzed the data of these 5 patients (6 lesions).

RESULTS:
There were 4/patient (median, range 2-12) and 3.5/lesion (median, range 2-10) intraoperative IA-ICG runs. IA-ICG videoangiography detected RVD in all patients. Clearance of IA-ICG–induced fluorescence was achieved within 30 seconds in all patients at each region of interest. After the disconnection of the fistulae, IA-ICG videoangiography and intraoperative digital subtraction angiography (DSA) confirmed the disappearance of RVD in all patients. There were no complications associated with IA-ICG videoangiography.

CONCLUSION:
This study showed that IA-ICG videoangiography is repeatable within a short period of time before and after obliteration and can be useful for detecting RVD and shunt occlusion in cranial- and CCJ-AVF surgery. IA-ICG videoangiography also allows intraoperative DSA studies in a hybrid operating room. Considering the recent advancements in hybrid operating rooms, combining IA-ICG videoangiography with intraoperative DSA is a useful strategy for cranial- and CCJ-AVF surgery.
Assessing the impact on growth and yield in different varieties of chili pepper (Capsicum frutescens) intercropped with chaya (Cnidoscolus aconitifolius)
Authors: GUSTIAR FITRA , LAKITAN BENYAMIN , BUDIANTA DEDIK , NEGARA ZAIDAN P. 
Published: June 2023

Abstract. Gustiar F, Lakitan B, Budianta D, Negara ZP. 2023. Assessing the impact on growth and yield in different varieties of chili pepper (Capsicum frutescens) intercropped with chaya (Cnidoscolus aconitifolius). Biodiversitas 24: 2639-2646. Intercropping chaya and chili plants is advantageous as it can boost land productivity and increase farmer income. However, the growth of the chili plant is more likely to be hampered by the shade formed by the canopy of the chaya plant. Therefore, this study aimed to investigate the response of chili to the shade of the chaya plant canopy and identify varieties that can thrive in intercropping systems. The experiment was arranged based on a split-plot design with a planting pattern as the main plot, consisting of chili monoculture, intercropping of chaya-chili, and intercropping of pruned-canopy chaya with chili. Three chili varieties, i.e., Rajo, Taruna, and Bara, were the subplots with four replications. Chaya plants were planted at a distance of 200 x 200 cm. Chaya-chili intercropping was done by inserting two rows of chili plants with a distance of 50 x 50 cm between rows of chaya plants. The results showed that chili pepper planted in an intercropping system exhibit an etiolation effect as indicated by a taller stem but with fewer leaves than the chili plants cultivated with a monoculture system. The shading effect of the chaya plant resulted in lower leaf temperature of the chili peppers in intercropping system. Pruning treatment on the shoots of chaya plants positively impacted the growth and yield of chili plants, which was indicated by an increase in biomass weight and fruit yield. The Bara variety was harvested two weeks earlier and produced higher fruit yields compared to Rajo and Taruna varieties. The growth and yield of chili plants were relatively comparable between the monoculture and intercropping system if the canopy pruning in chaya plants was carried out, especially in the Bara variety.
Morphological and molecular characteristics of Donax incarnatus (Bivalvia: Donacidae) from Badur Beach, Madura Island, Indonesia based on the COX1 gene
Authors: WIJAYA CATHERINE BERLIANA , AMBARWATI RENI , RAHAYU DWI ANGGOROWATI 
Published: June 2023

Abstract. Wijaya CB, Ambarwati R, Rahayu DA. 2023. Morphological and molecular characteristics of Donax incarnatus (Bivalvia: Donacidae) from Badur Beach, Madura Island, Indonesia based on the COX1 gene. Biodiversitas 24: 2805-2813. Donacidae, a family of marine bivalve mollusks, has a high diversity of morphological traits, including shape and color pattern variations. However, these variations often led to errors in morphological identification, necessitating the use of molecular identification methods for accurate species identification and support. This study aims to analyze the morphological and molecular characteristics of Donax incarnatus Gmelin, 1791 collected from Badur Beach of Madura Island, Sumenep District, East Java Province, Indonesia, using the COX1 gene as a molecular marker. Morphological characterization was conducted through qualitative and quantitative observations, while sequencing results were analyzed using bioinformatics software. The results showed that the exterior color of D. incarnatus has three morphological variations, namely purple-black (OQ692130.1), yellowish orange (OQ692131.1), and white (OQ692132.1). Molecular characterization indicated that the similarity value of D. incarnatus with these variations ranged from 96.06% to 99.61%. At the same time, the alignment results of all samples with reference species and outgroups obtained five variations of nucleotide bases. The average genetic distance between D. incarnatus and the in group was 0.01. The phylogenetic tree results obtained using Neighbor-Joining (NJ) and Maximum Likelihood (ML)methods were categorized into two subclusters: D. incarnatus species from Thailand and the study sample from Badur Beach, Madura Island, Indonesia, were placed in the same cluster.
Optimization of culture medium and bioformulation of rhizobial actinomycetes to enhance soybean plant growth
Authors: FATMAWATI UMI , QURRATA’AINI MEFTA RIZKI , ROSYIDI NOVIAN WILDAN , SARI DEWI PUSPITA , SANTOSA SLAMET 
Published: June 2023

Abstract. Fatmawati U, Qurrata’aini MR, Rosyidi NW, Sari DP, Santosa S. 2023. Optimization of culture medium and bioformulation of rhizobial actinomycetes to enhance soybean plant growth. Biodiversitas 24: 2912-2918. Actinomycetes are a group of Gram-positive bacteria that are well-known for having plant growth-promoting activity. In an earlier study, Streptomyces sp. strain ASR 58 and Streptomyces sp. strain ASR 67, isolated from soybean rhizosphere, were found to be capable of producing Indole-Acetic Acid (IAA), dissolving phosphate, and stimulating soybean growth. Optimization of culture media and selection of carrier materials for formulation are necessary to maintain actinomycetes' cell viability and plant growth property stability. This study aimed to evaluate several culture media, determine the optimal carrier materials in actinomycetes formulation, and evaluate the effect of actinomycete bioformulation on the soybean plant growth in planta. The sugar potato broth medium was the best in increasing the cell biomass of ASR 67 and co-culture of ASR 58 and ASR 67 compared to other mediums (skim molasses and rice bran broth). The viability of ASR 58 cell (5.3 x 107 CFU/mL), ASR 67 (3.8 x 107 CFU/mL), and its combination of both (4.3 x 107 CFU/mL) was best maintained in talc powder carrier during 10 weeks of storage as revealed by the number of viable cells decreases. Applying ASR 58 and ASR 67 co-culture on talc powder formula enhanced soybean plant biomass four weeks after planting, including plant height, the number of leaves, and root dry weight.
Physicochemical properties in NOR tomato line MA 131-6-3 after treated with ethephon and calcium carbide induced ripening
Authors: KHAIRI ALFASSABIQ , MURTI RUDI HARI , IRWAN SITI NURUL ROFIQO , PUTRA EKA TARWACA SUSILA 
Published: June 2023

Abstract. Khairi A, Murti RH, Irwan SNR, Putra ETS. 2023. Physicochemical properties in NOR tomato line MA 131-6-3 after treated with ethephon and calcium carbide induced ripening. Biodiversitas 24: 3029-3037. Tomato fruit Postharvest Losses (PHL) from rotting, Physiological Weight Loss (PWL), inadequate nutrition, and other factors can lower fruit quality. Tomato is included as climacteric fruit which shows a significant increase in respiration and ethylene. The use of tomato with an extended shelf life due to genetic engineering, such as a Non-Ripening (NOR) tomato, can lower PHL. This experiment was carried out to evaluate physicochemical characteristics of NOR tomato fruit (lineMA 131-6-3 as result of selection F6)during postharvest after being treated by Ethephon (ET) (375, 750, 1,125, and 1,500 ppm), calcium carbide (CaC2) (5, 10, 15, and 20 gkg?1), and control. The experimental design was arranged in Randomized Completely Block Design with three replications.The ambient temperature was 28.30±1.75°C and relative humidity of 60.69±2.33%. The results showed the fruit ripening and physicochemical altered with CaC2 treatment, then followed by yellow but did not alter to the red color for all treatments. The value of reduction sugar, respiration, ethylene, PWL, and pH increased, meanwhile the fruit firmness decreased caused by CaC2. Furthermore, ET could increase rotting during storage.
The rupture risk factors of mirror intracranial aneurysms: A systematic review and meta-analysis based on morphological and hemodynamic parameters
Authors: Yong-Wei Huang , Wang Xiao-Yi , Li Zong-Ping , Yin Xiao-Shuang 
Published: June 2023

Objective
Intracranial aneurysms (IAs) are a prevalent form of vascular disease that can lead to fatal outcomes upon rupture. Mirror intracranial aneurysms (MIAs) are a specific type of multiple aneurysms situated symmetrically on both sides of the parent arteries. The factors contributing to the risk of MIA rupture, based on morphological and hemodynamic parameters, are currently controversial. Thus, we conducted a systematic review and meta-analysis to investigate the risk factors for MIA rupture.

Methods
The study performed an electronic search of Chinese and English databases, including China national Knowledge Infrastructure (CNKI), WanFang, VIP, PubMed, Embase, Web of Science, Scopus, and the Cochrane Library databases, and adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The morphological parameters (IA size, aspect ratio [AR], size ratio [SR], bottleneck factor [BNF], height-width ratio [HWR], irregular shape) and hemodynamic parameters (wall shear stress [WSS], low WSS area [LSA], oscillatory shear index [OSI]) were analyzed for their significance in determining the risk of MIA rupture.

Results
The analysis comprised 18 retrospective studies involving 647 patients, with a total of 1294 IAs detected, including 605 ruptured and 689 unruptured. The meta-analysis revealed that IA size, AR, SR, and irregular shape exhibited significant differences between the ruptured and unruptured groups, but HWR did not. In terms of hemodynamic parameters, WSS, OSI, and LSA were found to have significant differences between the two groups.

Conclusions
Our results demonstrate that larger IAs, higher AR, SR, and BNF are associated with a higher risk of rupture in patients with MIAs, regardless of their location. there is no significant difference in HWR between the ruptured and unruptured groups. These preliminary findings offer valuable insights for clinical decision-making and a more comprehensive comprehension of the current MIA status. Nevertheless, larger and multi-center studies are indispensable for corroborating these findings.
Systematic review registration: https://www.crd.york.ac.uk/prospero/ identifier: CRD42022345587.
Using a person-centered approach in clinical care for patients with complex chronic conditions: Perspectives from healthcare professionals caring for Veterans with COPD in the U.S. Veterans Health Administration’s Whole Health System of Care
Authors: Anderson Ekaterina , Wiener Renda Soylemez , Molloy-Paolillo Brianne , McCullough Megan , Kim Bo , Harris J. Irene , Rinne Seppo T. , Elwy A. Rani , Bokhour Barbara G. 
Published: June 2023

Background
The largest nationally integrated health system in the United States, the Veterans Health Administration (VHA), has been undergoing a transformation toward a Whole Health (WH) System of Care. WH Clinical Care, a component of this system, includes holistically assessing the Veteran’s life context, identifying what really matters to the Veteran, collaboratively setting and monitoring personal health and well-being goals, and equipping the Veteran with access to conventional and complementary and integrative health resources. Implementation of WH Clinical Care has been challenging. Understanding healthcare professionals’ perspectives on the value of and barriers and facilitators to practicing WH Clinical Care holds relevance for not only VHA’s efforts but also other health systems, in the U.S. and internationally, that are engaged in person-centered care implementation.

Objectives
We sought to understand perspectives of healthcare professionals at VHA on providing WH Clinical Care to Veterans with COPD, as a lens to understand the broader issue of WH Clinical Care for Veterans living with complex chronic conditions.

Design
We interviewed 25 healthcare professionals across disciplines and services at a VA Medical Center in 2020–2021, including primary care providers, pulmonologists, palliative care providers, and chaplains. Interview transcripts were analyzed using qualitative content analysis.

Key results
Each element of WH Clinical Care raised complex questions and/or concerns, including: (1) the appropriate depth/breadth of inquiry in person-centered assessment; (2) the rationale for elicitation of what really matters; (3) the feasibility and appropriate division of labor in personal health goal setting and planning; and (4) challenges related to referring Veterans to a broad spectrum of supportive services.

Conclusions
Efforts to promote person-centered care must account for healthcare professionals’ existing comfort with its elements, advocate for a team-based approach, and continue to grapple with the conflicting structural conditions and organizational imperatives.
Comparison of two suture techniques on the inflammatory signs after third molars extraction–A randomized clinical trial
Authors: Rodrigues Éwerton Daniel Rocha , Martins-de-Barros Allan Vinícius , Loureiro Ariana Maria Luccas Costa , Carvalho Marianne de Vasconcelos , Vasconcelos Belmiro 
Published: June 2023

Purpose
Wound closure technique is an operative factor that influences early post-operative complications after third molar surgery. This study investigates and compared the effectiveness of two closure techniques, primary closure and healing by second intention of the oblique incision on postsurgical discomfort after mandibular third molar surgery.

Materials and methods
This is a prospective, randomized, double-blind, split mouth controlled trial. Surgical sites were divided into two groups Control group received simple sutures in both alveolar crest incision and oblique incision and intervention group received simple sutures in alveolar crest incision, while the oblique incision healed by second intention. All the patients were instructed to measure pain according to visual analogue scale (VAS) in postoperative period, swelling, mouth opening was assessed at 72h and 7 days after surgery. The wound healing was assessed on day 7.

Results
Thirty-five patients, who had bilateral impacted third molars of similar surgical difficulty, were recruited. Thirty-one successfully completed the study. Patients in the second intention group had significantly less pain at 24h (p < 0.27). and 48h (< 0.001), had significantly less swelling (< 0.001) and trismus (< 0.001) and patients submitted to primary closure had a better evaluation of the Landry index (p < 0.001).

Conclusion
Healing by second intention of the oblique relaxing incision by partial surgical wound closure, in our study, were superior to the primary closure in reduction of post-operative pain, swelling and trismus.

Trial registration
This trial is registered at Brazilian Registry of Clinical Trials–ReBEC -UTN: RBR-5fxbqsf (https://ensaiosclinicos.gov.br/rg/RBR-5fxbqsf).
Intravenous chloral hydrate anesthesia provides appropriate analgesia for surgical interventions in male Sprague-Dawley rats
Authors: Ward-Flanagan Rachel , Dickson Clayton T. 
Published: June 2023

Background
The use of chloral hydrate as a sole maintenance anesthetic agent in rodent research has been controversial due to statements made in reference literature conflicting with results of primary research studies regarding its analgesic efficacy, and because of its associated tissue damage when administered intraperitoneally.

Objective
Our aim was to assess the analgesic efficacy of chloral hydrate using an intravenous (i.v.) route of administration, in order to prevent the local tissue irritation or ileus that has been previously reported using intraperitoneal (i.p.) routes.

Methods
We measured tail withdrawal latencies to a nociceptive thermal stimulus (infrared beam) in Sprague-Dawley rats–first when awake (unanesthetized), and then subsequently during i.v. chloral hydrate anesthesia. During anesthesia we also measured ongoing heart and respiration rates.

Results
Withdrawal latencies during chloral hydrate anesthesia were significantly higher, and often maximal, indicating a robust analgesic effect. Importantly, both respiration and heart rate remained unchanged following exposure to the nociceptive stimulus, and were comparable to values observed under other anesthetics and during natural sleep.

Conclusions
Together with previous studies, these results demonstrate that i.v. chloral hydrate provides excellent anesthetic depth and analgesic efficacy for surgical manipulations in rats.
Effects of a time-use intervention in isolated patients with coronavirus disease 2019: A randomized controlled study
Authors: Jung Jae Hyu , Ko Jin Young , Hong Ickpyo , Jung Min-Ye , Park Ji-Hyuk 
Published: June 2023

Objective
Patients with coronavirus disease experience deterioration in occupational balance and mental health. The primary objective of this study was to determine the effectiveness of a time-use intervention on the occupational balance of isolated patients with coronavirus disease. Its impact on secondary outcomes including mental health and quality of life was also assessed.

Methods
This randomized controlled clinical trial was conducted in a single community-based hospital. Forty-one patients (19 in the experimental group and 22 in the control group) with coronavirus disease were recruited between February 1, 2021, and March 19, 2021. Participants were randomly assigned to receive a time-use intervention or education on self-activity. The time-use intervention is to plan a daily routine to engage in meaningful occupations. It consisted of 4 steps: time-use analysis, occupation selection, arrangement of activities and practice, and occupational therapist intervention. The control group was educated on self-activity and spent time autonomously.

Outcomes and measures
The primary outcome was occupational balance, evaluated using the Korean version of the Life Balance Inventory. Secondary outcomes were mental health and quality of life assessed using the Korean version of the Patient Health Questionnaire-9, Korean Form of Zung’s Self-Rating Anxiety Scale, Korean version of the Insomnia Severity Index, Multidimensional State Boredom Scale-8, Fear of Coronavirus Disease: Korean version of the Fear of Coronavirus Disease Scale, and World Health Organization Quality of Life Assessment Instrument-BRIEF. Outcome measures were evaluated at admission and discharge.

Results
The time-use intervention significantly improved occupational balance (F = 14.12, p < .001) and all other measures of depression, anxiety, boredom, fear, and quality of life. Conversely, the control group showed a worsening pattern for all measures.

Conclusion
The time-use intervention is effective for improving occupational balance, mental health, and quality of life in patients with coronavirus disease.