bluuebunny/crossref_metadata_2025_split huggingface dataset:
Arrom, Silvia Marina, La Güera Rodríguez. Mito y mujer, México, Turner Noema, 2020, pp. 247. ISBN: 978-607-7711-31-5. Pp. 247.
Authors: Navarro Méndez José María 
Published: June 2023

La Biografía -con mayúscula-, es un interesante método y practica de la Historia, con la cual un investigador puede mostrar su habilidad y amplio conocimiento sobre un personaje y su contexto; espacial y temporal, en ella, es decir, en la Biografía, las experiencias profesionales del investigador buscan mostrar y entender la vida y la realidad de un actor histórico, buscan dar una respuesta sobre; quién fue, cómo fue, cómo vivió, en qué ambiente se desarrolló, etc., intentado en todo momento descifrar y desenmarañar; la verdad y la ficción, que pueda haber entorno a su sujeto de estudio, sin importar su género, los biógrafos intentan que cada generación vea a sus biografiados desde una perspectiva diferente, de manera que se siga discutiendo el tema por mucho más tiempo.
Los historiadores y los biógrafos escogen muchas veces a sus objetos de estudio en base a sus intereses investigativos previos, muchos historiadores de lo militar se animan a recuperar vidas de los hombres y mujeres enrolados en la carrera de las armas, así como las y los historiadores dedicados a la historia política buscan ver la vida de sus personajes dentro de las vicisitudes de la política, en ambos casos la elección de sus personajes responde directamente al interés personal y también al nivel de visibilidad que un personaje histórico tenga, pues puede que sean individuos cuya vida sea muy bien conocida, donde la ficción o la mitificación sea muy escaza o puede que sean individuos cuya magnitud salte y sea difícil reconocer el personaje mítico del personaje real.
El nacer en tiempos de pandemia
Authors: Mueses Miguel Ángel 
Published: June 2023

El 11 de marzo de 2020 la Organización Mundial de la Salud (OMS) reconoció como una pandemia por coronavirus a la enfermedad de la COVID-19, ocasionada por el virus SARS-CoV-2 [1]. Desde entonces, han pasado alrededor de dos años y a pesar del desarrollo de las nuevas vacunas, estamos entrando a un tercer año de pandemia, todavía con un panorama difuso en el control global de esta tragedia mundial.
Una de las frases más usadas desde entonces ha sido “la pandemia nos obligó a reinventarnos”, que aunque suene a cliché, es una verdad absoluta. La parálisis del mundo y los colapsos apocalípticas de las economías de los países nos afectaron a todos en mayor o menor medida. La perdida de vidas de millones de personas alrededor del globo, la caída en la pobreza de otras tantos millares, los centenares de miles de empresas cerradas, incontables empleos perdidos, el cambio en la vida misma, nos dejaron enseñanzas duras, pero al final valiosas, de las cuales rescato dos: la primera es que a pesar de la tragedia, la humanidad volvió a ser humana, al menos en gran parte, afloró la filantropía y el altruismo en muchos aspectos, sin olvidar a los animales y al medio ambiente . La segunda, es que la única forma de salir delante de todo esto fue confiar en la ciencia verdadera. Nuestros grandes héroes han sido el personal médico y lógicamente los científicos de todo el mundo, unidos tratando de combatir y mitigar los efectos de esta desventura.
Comparison of Poisson Regression and Conway Maxwell Poisson Models Using Simulation
Authors: Adnan Radam Sarah , Mohammed Ali Hameed Lamyaa 
Published: June 2023

Regression models are one of the most important models used in modern studies, especially research and health studies because of the important results they achieve. Two regression models were used: Poisson Regression Model and Conway-Max Well- Poisson), where this study aimed to make a comparison between the two models and choose the best one between them using the simulation method and at different sample sizes (n = 25,50,100) and with repetitions (r = 1000). The Matlab program was adopted.) to conduct a simulation experiment, where the results showed the superiority of the Poisson model through the mean square error criterion (MSE) and also through the Akaiki criterion (AIC) for the same distribution.
Paper type: Research paper.
Necesidades de formación psicopedagógicas de los docentes en atención al sistema educativo inclusivo, de los adolescentes que cursan el bachillerato general unificado
Authors: Espín Marcillo Lilian Cumandá , Espín Marcillo Ana Lucía , Chamba Chamba Ovidio Benigno , Zambrano Semblantes Oscar Washington 
Published: June 2023

Introducción: Los debates sobre los fundamentos epistemológicos de la integración de la psicología y la pedagogía en los diversos campos de la educación se expresan inicialmente en diferentes contextos científicos a partir de las necesidades e inquietudes de los profesionales, siendo el interés profundizar aspectos de su práctica educativa. Objetivo: Analizar la importancia de la formación del docente con perspectiva en la inclusión educativa. Fundamentar teóricamente las necesidades de la formación del docente. Identificar los factores que afectan en la inclusión educativa y atención a la diversidad de los estudiantes. Reflexionar acerca de los desafíos que enfrenta el docente en el sistema educativo inclusivo. Metodología: se utiliza en este estudio es del tipo investigación-acción, genera simultáneamente conocimiento y cambios, conectando el aspecto cognitivo con el conocimiento y la adquisición de saberes a través de la recolección de información confiable y precisa. Resultados: el sistema formativo actual, tiene la centralidad del maestro como recurso educativo técnico e insustituible. Además, existe la necesidad de continuar la formación docente para lograr el desarrollo de habilidades de resolución de problemas en el campo de la educación con un enfoque psicopedagógico. Conclusión: La formación docente debe mejorarse de acuerdo con las necesidades y exigencias de un nuevo tipo de educación, porque la educación es la causa de la sociedad actual y el motor del futuro. A partir de este análisis, se destacó que el concepto de formación docente promueve la preparación necesaria y la orientación basada en necesidades para la gestión del proceso educativo en sus campos de actuación: en la institución, la familia y la comunidad. Área de estudio: Pedagogía.
Retrospective Study of Ligature Material on Suicidal Hanging
Authors: Akhter Syeda Sharmina , Salim Airin , Hossain Mohammad Monir , Uddin Razib SM Jashim , Karmakar Pijush 
Published: June 2023

Background: Hanging is one of the most common methods of suicide. It is always suicidal unless otherwise proved. Recent evidence showed that the incidence of suicide by hanging has increased especially among young adults. Ligature material plays an important role in leading investigation in hanging. The ligature material depends on its accessibility and availability. Various ligature materials are being used like nylon rope, cotton rope, wire, synthetic saree, lungi etc.
Objective: Present study is a humble effort to find out the choice of ligature material used by the victim at Dhaka Medical College.
Materials and methods: A retrospective study was conducted at the mortuary of Forensic medicine department, Dhaka Medical College Hospital, Dhaka, Bangladesh from July 2017 to December 2018. During this period data were collected from 112 cases of medicolegal autopsies by purposive sampling.
Result: A total of 112 medicolegal autopsies were analyzed. In this hanging death, the most common ligature material used was rope in 58% of cases followed by dupatta (13%), lungi (11%) and saree (9%). Electric wire and kamiz were other ligature material used for hanging. The consistency of ligature material observed was hard (71%) & width is narrow width is (71%). Majority of cases (71%) were observed is male. Complete hanging was seen in 67% of cases & among them 85% cases are atypical hanging.
Conclusion: Hanging is always suicidal unless otherwise proved. It is the form of painless violent asphyxia death that is widely practiced method of suicide. The most used ligature material is rope. Rope is chosen as ligature material due to its availability and accessibility. Young people in the justice system may need personal and psychological support to reduce the incidence of suicide.
Eastern Med Coll J. Jan 2023; 8 (1) 12-14
Adenoid Cystic Carcinoma: A Case Report
Authors: Hossen Iqbal , Chowdhury Farid Hossain , Shil Niloy Ananda , Qader Mirza Md Aminul , Chowdhury M Alamgir , Ullah Md Kalim 
Published: June 2023

A 52-year-old male patient attended on 13 July 2022 with the complaints of pain in right ear and voice change for 1 month and cough for 15 days, difficulty in swallowing along with weight loss for same duration of past 1 month. Examination revealed a swelling on the right side of neck over the submandibular region also with cervical lymphadenopathy (level IB). After all evaluation, all biochemical tests were normal, but Fiber Optic Laryngoscopy (FOL) revealed right vocal cord palsy, USG of neck revealed right submandibular mass and cervical lymphadenopathy, CT scan of Neck up to Mid-chest revealed no pathology and last but not the least pre-operative FNAC was done and revealed organizing abscess. After that patient underwent excision of the right sub mandibular mass and removal of few superficial group of lymph nodes. Post-operative histopathology revealed Adenoid Cystic Carcinoma (ACC). Patient presented to us with no complain about submandibular gland or fine needle aspiration cytology (FNAC) also doesn’t indicate about malignancy, but our clinical suspicion was submandibular gland malignancy, that’s why we have decided to publish this case report. After operation Patient was fine till his last follow-up.
Eastern Med Coll J. Jan 2023; 8 (1) 28-30
The Effect Of Technology Characteristics In The Continued Use Of Charity Crowdfunding Platforms Through Trust And User Satisfaction
Authors: Almuntaha Eska , Rahmawati Nur 
Published: June 2023

This research's objective is to examine the effect of technological characteristics on trust and satisfaction in using a charity crowdfunding platform so that the user will reuse the platform. The use of technology in excellent and sustainable online donation fundraising requires the fulfilment of technological characteristics. A study by Bhattacherjee (2001)) stated that continued use influences information technology's success. Another significant area in information systems research is user satisfaction because it is an essential factor in measuring the use and success of an information system (Bailey and Pearson, 1983; Ives et al., 1983; Doll and Torkzadeh, 1988; Delone and McLean, 1992 in Roca et al., 2006). This study used the purposive sampling method and tested the hypothesis using the Structural Equation Model (SEM). This research proves that trust affects the satisfaction of using a charity crowdfunding platform, but not with technological characteristics. Meanwhile, users' satisfaction influences continued use but not trust.
Keywords: Technology Characteristics, Continued Use, User Satisfaction, User Trust, Charity Crowdfunding Platform.
ANALISIS MANAJEMEN RESIKO KEUANGAN BUMN TERHADAP PERTUMBUHAN LABA
Authors: Fitri Hyuliana , Oktavianti Oktavianti 
Published: June 2023

Penelitian ini dilakukan untuk mengetahui dan menganalisis: (1) Retun On Equity (ROE) berpengaruh terhadap Pertumbuhan Laba perusahaan BUMN periode 2014-2018 (2) Return On Investment (ROI) berpengaruh terhadap terhadap Pertumbuhan Laba perusahaan BUMN periode 2014-2018 (3) Cash Ratio berpengaruh terhadap terhadap Pertumbuhan Laba perusahaan BUMN periode 2014-2018 (4) Current Ratio berpengaruh terhadap terhadap Pertumbuhan Laba perusahaan BUMN periode 2014-2018 (5) Collection Periods (CP) berpengaruh terhadap terhadap Pertumbuhan Laba perusahaan BUMN periode 2014-2018 (6) Perputaran Persediaan (PP) berpengaruh terhadap terhadap Pertumbuhan Laba perusahaan BUMN periode 2014-2018 (7) Total Asset Turn Over (TATO) berpengaruh terhadap Pertumbuhan Laba perusahaan BUMN periode 2014-2018 (8) Total Modal Sendiri terhadap Total Aset (TMS thd TA) berpengaruh terhadap terhadap Pertumbuhan Laba perusahaan BUMN periode 2014-2018 (9) Return On Equity, Return On Investment, Cash Ratio, Current Ratio, Collection Periods, Perputaran Persediaan, Total Asset Turn Over, dan Total Modal Sendiri terhadap Total Aset secara simultan berpengaruh terhadap Pertumbuhan Laba perusahaan BUMN periode 2014-2018.
INOVASI DESAIN KEMASAN PRODUK RUMAH MAKAN BONELO
Authors: Muhammad Ashar , Kalsum Ummi 
Published: June 2023

Industri kuliner saat ini berkembang pesat di Indonesia salah satunya rumah makan yang mudah ditemui dengan berbagai hidangan makanan dan minuman. Semakin berkembang bisnis rumah makan menyebabkan tingginya tingkat persaingan menuntut rumah makan melakukan inovasi agar mampu bertahan dalam dunia bisnis. Desain kemasan merupakan strategi yang dapat digunakan perusahaan untuk bersaing dalam dunia bisnis. Rumah Makan (RM) Bonelo merupakan salah satu rumah makan yang ada di Kota Makassar. RM Bonelo memiliki permasalahan pada kemasan produk yang dimana kemasan makanannya kurang menarik dan gampang rusak sehingga pada penelitian menghasilkan output sebuah inovasi desain kemasan produk. Pada penelitian ini menggunakan metode kualitatif dengan metode pengumpulan wawancara dan observasi. Dengan adanya inovasi kemasan produk pada kemasan RM Bonelo dapat meningkatkan penjualan dan keuntungan.
miR-9 utilizes precursor pathways in adaptation to alcohol in mouse striatal neurons
Authors: Mead Edward Andrew , Wang Yongping , Patel Sunali , Thekkumthala Austin P. , Kepich Rebecca , Benn-Hirsch Elizabeth , Lee Victoria , Basaly Azra , Bergeson Susan , Siegelmann Hava T. , Pietrzykowski Andrzej Zbigniew 
Published: June 2023

microRNA-9 (miR-9) is one of the most abundant microRNAs in the mammalian brain, essential for its development and normal function. In neurons, it regulates the expression of several key molecules, ranging from ion channels to enzymes, to transcription factors broadly affecting the expression of many genes. The neuronal effects of alcohol, one of the most abused drugs in the world, seem to be at least partially dependent on regulating the expression of miR-9. We previously observed that molecular mechanisms of the development of alcohol tolerance are miR-9 dependent. Since a critical feature of alcohol action is temporal exposure to the drug, we decided to better understand the time dependence of alcohol regulation of miR-9 biogenesis and expression. We measured the effect of intoxicating concentration of alcohol (20 mM ethanol) on the expression of all major elements of miR-9 biogenesis: three pri-precursors (pri-mir-9-1, pri-mir-9-2, pri-mir-9-3), three pre-precursors (pre-mir-9-1, pre-mir-9-2, pre-mir-9-3), and two mature microRNAs: miR-9-5p and miR-9-3p, using digital PCR and RT-qPCR, and murine primary medium spiny neurons (MSN) cultures. We subjected the neurons to alcohol based on an exposure/withdrawal matrix of different exposure times (from 15 min to 24 h) followed by different withdrawal times (from 0 h to 24 h). We observed that a short exposure increased mature miR-9-5p expression, which was followed by a gradual decrease and subsequent increase of the expression, returning to pre-exposure levels within 24 h. Temporal changes of miR-9-3p expression were complementing miR-9-5p changes. Interestingly, an extended, continuous presence of the drug caused a similar pattern. These results suggest the presence of the adaptive mechanisms of miR-9 expression in the presence and absence of alcohol. Measurement of miR-9 pre- and pri-precursors showed further that the primary effect of alcohol on miR-9 is through the mir-9-2 precursor pathway with a smaller contribution of mir-9-1 and mir-9-3 precursors. Our results provide new insight into the adaptive mechanisms of neurons to alcohol exposure. It would be of interest to determine next which microRNA-based mechanisms are involved in a transition from the acute, intoxicating effects of alcohol to the chronic, addictive effects of the drug.
GliSODin® prevents airway inflammation by inhibiting T-cell differentiation and activation in a mouse model of asthma
Authors: Klein Martin , Dijoux Eleonore , Cheminant Marie-Aude , Intes Laurent , Bouchaud Grégory 
Published: June 2023

BackgroundAsthma is a chronic inflammatory airway disease characterized by a prevailing type 2 inflammation, airway hyperresponsiveness, and mucus hypersecretion and is driven by various factors among which oxidative molecules, called reactive oxygen species (ROS), play a major role. Superoxide dismutases (SODs) are enzymes that constitute the first line of defense against ROS. Melon SOD-gliadin, which is known as GliSODin®, is commonly used as a nutritional supplement that has proven antioxidant properties.ObjectivesIn this study, we evaluated the efficacy and mechanism of action GliSODin® in the treatment of allergic asthma.MethodsHouse dust mite (HDM)-induced asthmatic mice were orally exposed to GliSODin®, and airway hyperresponsiveness, lung inflammation,in vitroT-cell polarization,in vivoT-cell reactivation, and blood immunoglobulin were investigated.ResultsGliSODin® reduced airway hyperresponsiveness, lung innate and adaptive immune response, and HDM-specific IgE production. Coculturing CD4+ T-cell with HDM-sensitized dendritic cells and GliSODin® reduced T-cell polarization into Th2 and Th17 cells. Moreover, adoptively transferred CD4+ T cells from asthmatic mice exhibited a reduced reactivation of Th2 and Th17 cells following stimulation with HDM plus GliSODin®.ConclusionGliSODin® abrogates asthma features and reduces CD4+ T-cell polarization and reactivation. Taken together, these data suggest that GliSODin® could be used for the management of asthma symptoms.
Case report: Autosomal recessive type 3 Stickler syndrome caused by compound heterozygous mutations in COL11A2
Authors: Su Ying , Ran Chun-Qiong , Liu Zhe-Long , Yang Yan , Yuan Gang , Hu Shu-Hong , Yu Xue-Feng , He Wen-Tao 
Published: June 2023

Background: Stickler syndrome (SS) is a group of hereditary collagenopathies caused by a variety of collagen and non-collagen genes. Affected patients have characteristic manifestations involving ophthalmic, articular, craniofacial and auditory disorders. SS is classified into several subtypes according to clinical and molecular features. Type 3 SS is an ultra-rare disease, known as non-ocular SS or otospondylomegaepiphyseal dysplasia (OSMED) with only a few pathogenic COL11A2 variants reported to date.Case presentation: A 29-year-old Chinese male was referred to our hospital for hearing loss and multiple joint pain. He presented a phenotype highly suggestive of OSMED, including progressive sensorineural deafness, spondyloepiphyseal dysplasia with large epiphyses, platyspondyly, degenerative osteoarthritis, and sunken nasal bridge. We detected compound heterozygous mutations in COL11A2, both of which were predicted to be splicing mutations. One is synonymous mutation c.3774C&gt;T (p.Gly1258Gly) supposed to be a splice site mutation, the other is a novel intron mutation c.4750 + 5 G&gt;A, which is a highly conservative site across several species. We also present a review of the current known pathogenic mutation spectrum of COL11A2 in patients with type 3 SS.Conclusion: Both synonymous extonic and intronic variants are easily overlooked by whole-exome sequencing. For patients with clinical manifestations suspected of SS syndrome, next-generation whole-genome sequencing is necessary for precision diagnosis and genetic counseling.
Transarterial chemoembolization for advanced hepatocellular carcinoma without macrovascular invasion or extrahepatic metastasis: analysis of factors prognostic of clinical outcomes
Authors: Kim Ji Hoon , Kim Jin Hyoung , Yoon Hyun-Ki , Ko Gi-Young , Shin Ji Hoon , Gwon Dong Il , Ko Heung-Kyu , Chu Hee Ho , Kim Seong Ho , Kim Gun Ha , Kim Yonghun , Aljerdah Shakir 
Published: June 2023

ObjectivesTo evaluate the safety and efficacy of TACE and factors predicting survival in patients with advanced hepatocellular carcinoma (HCC) without macrovascular invasion (MVI) or extrahepatic spread (EHS).MethodsThis single-center retrospective study included 236 treatment-naïve patients who underwent TACE as first-line treatment for advanced HCC without MVI or EHS between January 2007 and December 2021.ResultsFollowing TACE, the median overall survival (OS) was 24 months. Multivariate Cox regression analyses revealed that tumor number ≥4 (risk point: 3), maximal tumor size &gt;10 cm (risk point: 2), Child–Pugh class B (risk point: 2), alpha-fetoprotein (AFP) concentration ≥400 ng/mL (risk point: 2), and presence of HCC rupture (risk point: 2) were risk factors significantly associated with OS. The expected median OS among patients with &lt;2, 2–4, and 5–9 risk points were 72, 29, and 12 months respectively. The major complication rates were significantly lower in patients with maximal tumor size ≤10 cm than in those with maximal tumor size &gt;10 cm (4% [5/138] vs 21% [21/98], p = 0.001).ConclusionTACE may be safe and effective in selected patients with advanced HCC without MVI or EHS, with a median OS of 24 months. Patients with limited tumor burden, compensated liver function, absence of HCC rupture, and favorable biologic markers may benefit the most from TACE. TACE is not recommended for patients with huge HCCs (&gt;10 cm) because of its high rate of major complications (21%).
Phylogenomics and plastome evolution of Indigofera (Fabaceae)
Authors: Zhou Sheng-Mao , Wang Fang , Yan Si-Yuan , Zhu Zhang-Ming , Gao Xin-Fen , Zhao Xue-Li 
Published: June 2023

IntroductionIndigofera L. is the third largest genus in Fabaceae and includes economically important species that are used for indigo dye-producing, medicinal, ornamental, and soil and water conservation. The genus is taxonomically difficult due to the high level of overlap in morphological characters of interspecies, fewer reliability states for classification, and extensive adaptive evolution. Previous characteristic-based taxonomy and nuclear ITS-based phylogenies have contributed to our understanding of Indigofera taxonomy and evolution. However, the lack of chloroplast genomic resources limits our comprehensive understanding of the phylogenetic relationships and evolutionary processes of Indigofera.MethodsHere, we newly assembled 18 chloroplast genomes of Indigofera. We performed a series of analyses of genome structure, nucleotide diversity, phylogenetic analysis, species pairwise Ka/Ks ratios, and positive selection analysis by combining with allied species in Papilionoideae.Results and discussionThe chloroplast genomes of Indigofera exhibited highly conserved structures and ranged in size from 157,918 to 160,040 bp, containing 83 protein-coding genes, 37 tRNA genes, and eight rRNA genes. Thirteen highly variable regions were identified, of which trnK-rbcL, ndhF-trnL, and ycf1 were considered as candidate DNA barcodes for species identification of Indigofera. Phylogenetic analysis using maximum likelihood (ML) and Bayesian inference (BI) methods based on complete chloroplast genome and protein-coding genes (PCGs) generated a well-resolved phylogeny of Indigofera and allied species. Indigofera monophyly was strongly supported, and four monophyletic lineages (i.e., the Pantropical, East Asian, Tethyan, and Palaeotropical clades) were resolved within the genus. The species pairwise Ka/Ks ratios showed values lower than 1, and 13 genes with significant posterior probabilities for codon sites were identified in the positive selection analysis using the branch-site model, eight of which were associated with photosynthesis. Positive selection of accD suggested that Indigofera species have experienced adaptive evolution to selection pressures imposed by their herbivores and pathogens. Our study provided insight into the structural variation of chloroplast genomes, phylogenetic relationships, and adaptive evolution in Indigofera. These results will facilitate future studies on species identification, interspecific and intraspecific delimitation, adaptive evolution, and the phylogenetic relationships of the genus Indigofera.