bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enhancement of pattern quality in maskless plasmonic lithography via spatial loss modulation
Authors: Han Dandan , Deng Sen , Ye Tianchun , Wei Yayi 
Published: March 2023

AbstractPlasmonic lithography, which uses the evanescent electromagnetic (EM) fields to generate image beyond the diffraction limit, has been successfully demonstrated as an alternative lithographic technology for creating sub-10 nm patterns. However, the obtained photoresist pattern contour in general exhibits a very poor fidelity due to the near-field optical proximity effect (OPE), which is far below the minimum requirement for nanofabrication. Understanding the near-field OPE formation mechanism is important to minimize its impact on nanodevice fabrication and improve its lithographic performance. In this work, a point-spread function (PSF) generated by a plasmonic bowtie-shaped nanoaperture (BNA) is employed to quantify the photon-beam deposited energy in the near-field patterning process. The achievable resolution of plasmonic lithography has successfully been enhanced to approximately 4 nm with numerical simulations. A field enhancement factor (F) as a function of gap size is defined to quantitatively evaluate the strong near-field enhancement effect excited by a plasmonic BNA, which also reveals that the high enhancement of the evanescent field is due to the strong resonant coupling between the plasmonic waveguide and the surface plasmon waves (SPWs). However, based on an investigation of the physical origin of the near-field OPE, and the theoretical calculations and simulation results indicate that the evanescent-field-induced rapid loss of high-k information is one of the main optical contributors to the near-field OPE. Furthermore, an analytic formula is introduced to quantitatively analyze the effect of the rapidly decaying feature of the evanescent field on the final exposure pattern profile. Notably, a fast and effective optimization method based on the compensation principle of the exposure dose is proposed to reduce the pattern distortion by modulating the exposure map with dose leveling. The proposed pattern quality enhancement method can open new possibilities in the manufacture of nanostructures with ultrahigh pattern quality via plasmonic lithography, which would find potentially promising applications in high density optical storage, biosensors, and plasmonic nanofocusing.
Emotion processing in youths with conduct problems: an fMRI meta-analysis
Authors: Berluti Kathryn , Ploe Montana L. , Marsh Abigail A. 
Published: March 2023

AbstractFunctional magnetic resonance imaging (fMRI) studies consistently indicate differences in emotion processing in youth with conduct problems. However, no prior meta-analysis has investigated emotion-specific responses associated with conduct problems. This meta-analysis aimed to generate an up-to-date assessment of socio-affective neural responding among youths with conduct problems. A systematic literature search was conducted in youths (ages 10–21) with conduct problems. Task-specific seed-based d mapping analyses examined responses to threatening images, fearful and angry facial expressions, and empathic pain stimuli from 23 fMRI studies, which included 606 youths with conduct problems and 459 comparison youths. Whole-brain analyses revealed youths with conduct problems relative to typically developing youths, when viewing angry facial expressions, had reduced activity in left supplementary motor area and superior frontal gyrus. Additional region of interest analyses of responses to negative images and fearful facial expressions showed reduced activation in right amygdala across youths with conduct problems. Youths with callous-unemotional traits also exhibited reduced activation in left fusiform gyrus, superior parietal gyrus, and middle temporal gyrus when viewing fearful facial expressions. Consistent with the behavioral profile of conduct problems, these findings suggest the most consistent dysfunction is found in regions associated with empathic responding and social learning, including the amygdala and temporal cortex. Youth with callous-unemotional traits also show reduced activation in the fusiform gyrus, consistent with reduced attention or facial processing. These findings highlight the potential role of empathic responding, social learning, and facial processing along with the associated brain regions as potential targets for interventions.
Influenza viral matrix 1 protein aggravates viral pathogenicity by inducing TLR4-mediated reactive oxygen species production and apoptotic cell death
Authors: Kim Chang-Ung , Lim Dahwan , Kim Young Sang , Ku Bonsu , Kim Doo-Jin 
Published: March 2023

AbstractInfluenza virus is one of the most challenging viruses threating human health. Since infection with influenza virus triggers inflammatory responses and induces cell death, the molecular and cellular mechanisms by which the virus-infected cells undergo apoptotic and necrotic cell death have been widely studied. However, most of the studies have focused on the molecular events occurring in the cytosol and there is limited information on the physiological correlation between virus-induced cell death and the viral pathogenesis in vivo. In this study, we demonstrate that the influenza virus matrix 1 (M1) protein is released from virus-infected cells and triggers apoptotic cell death of lung epithelial and pulmonary immune cells, through the activation of Toll-like receptor 4 (TLR4) signaling. Treatment with M1 protein led to robust cellular inflammatory responses, such as the production of proinflammatory cytokines and cellular reactive oxygen species (ROS), and induction of cell death. When M1 protein was administered in vivo, it induced the activation of inflammatory responses and cell death in the lungs. Furthermore, the administration of M1 aggravated lung pathology and mortality of the virus-infected mice in a TLR4-dependent manner. These results demonstrate that M1 is an important pathogenic factor contributing to influenza virus pathogenicity by enhancing cell death in the lungs, thereby expanding our understanding of the molecular mechanism of influenza virus-induced cell death through the interaction with an innate immune receptor.
Public attitudes toward cloud computing and willingness to share personal health records (PHRs) and genome data for health care research in Japan
Authors: Kusunose Mayumi , Muto Kaori 
Published: March 2023

AbstractJapan’s government aims to promote the linkage of medical records, including medical genomic testing data and personal health records (PHRs), via cloud computing (the cloud). However, linking national medical records and using them for health care research can be controversial. Additionally, many ethical issues with using cloud networks with health care and genome data have been noted. However, no research has yet explored the Japanese public’s opinions about their PHRs, including genome data, being shared for health care research or the use of the cloud for storing and analyzing such data. Therefore, we conducted a survey in March 2021 to clarify the public’s attitudes toward sharing their PHRs, including genome data and using the cloud for health care research. We analyzed data to experimentally create digital health basic literacy scores (BLSs). Our results showed that the Japanese public had concerns about data sharing that overlapped with structural cloud computing issues. The effect of incentives on changes in participants’ willingness to share data (WTSD) was limited. Instead, there could be a correlation between WTSD and BLSs. Finally, we argue that it is vital to consider not only researchers but also research participants as value cocreators in health care research conducted through the cloud to overcome both parties’ vulnerability.
A combinatorial code of neurexin-3 alternative splicing controls inhibitory synapses via a trans-synaptic dystroglycan signaling loop
Authors: Trotter Justin H. , Wang Cosmos Yuqi , Zhou Peng , Nakahara George , Südhof Thomas C. 
Published: March 2023

AbstractDisrupted synaptic inhibition is implicated in neuropsychiatric disorders, yet the molecular mechanisms that shape and sustain inhibitory synapses are poorly understood. Here, we show through rescue experiments performed using Neurexin-3 conditional knockout mice that alternative splicing at SS2 and SS4 regulates the release probability, but not the number, of inhibitory synapses in the olfactory bulb and prefrontal cortex independent of sex. Neurexin-3 splice variants that mediate Neurexin-3 binding to dystroglycan enable inhibitory synapse function, whereas splice variants that don’t allow dystroglycan binding do not. Furthermore, a minimal Neurexin-3 protein that binds to dystroglycan fully sustains inhibitory synaptic function, indicating that trans-synaptic dystroglycan binding is necessary and sufficient for Neurexin-3 function in inhibitory synaptic transmission. Thus, Neurexin-3 enables a normal release probability at inhibitory synapses via a trans-synaptic feedback signaling loop consisting of presynaptic Neurexin-3 and postsynaptic dystroglycan.
Turning universal O into rare Bombay type blood
Authors: Anso Itxaso , Naegeli Andreas , Cifuente Javier O. , Orrantia Ane , Andersson Erica , Zenarruzabeitia Olatz , Moraleda-Montoya Alicia , García-Alija Mikel , Corzana Francisco , Del Orbe Rafael A. , Borrego Francisco , Trastoy Beatriz , Sjögren Jonathan , Guerin Marcelo E. 
Published: March 2023

AbstractRed blood cell antigens play critical roles in blood transfusion since donor incompatibilities can be lethal. Recipients with the rare total deficiency in H antigen, the OhBombay phenotype, can only be transfused with group Ohblood to avoid serious transfusion reactions. We discover FucOB from the mucin-degrading bacteriaAkkermansia muciniphilaas an α-1,2-fucosidase able to hydrolyze Type I, Type II, Type III and Type V H antigens to obtain the afucosylated Bombay phenotype in vitro. X-ray crystal structures of FucOB show a three-domain architecture, including a GH95 glycoside hydrolase. The structural data together with site-directed mutagenesis, enzymatic activity and computational methods provide molecular insights into substrate specificity and catalysis. Furthermore, using agglutination tests and flow cytometry-based techniques, we demonstrate the ability of FucOB to convert universal O type into rare Bombay type blood, providing exciting possibilities to facilitate transfusion in recipients/patients with Bombay phenotype.
Cryo-tomography reveals rigid-body motion and organization of apicomplexan invasion machinery
Authors: Gui Long , O’Shaughnessy William J. , Cai Kai , Reetz Evan , Reese Michael L. , Nicastro Daniela 
Published: March 2023

AbstractThe apical complex is a specialized collection of cytoskeletal and secretory machinery in apicomplexan parasites, which include the pathogens that cause malaria and toxoplasmosis. Its structure and mechanism of motion are poorly understood. We used cryo-FIB-milling and cryo-electron tomography to visualize the 3D-structure of the apical complex in its protruded and retracted states. Averages of conoid-fibers revealed their polarity and unusual nine-protofilament arrangement with associated proteins connecting and likely stabilizing the fibers. Neither the structure of the conoid-fibers nor the architecture of the spiral-shaped conoid complex change during protrusion or retraction. Thus, the conoid moves as a rigid body, and is not spring-like and compressible, as previously suggested. Instead, the apical-polar-rings (APR), previously considered rigid, dilate during conoid protrusion. We identified actin-like filaments connecting the conoid and APR during protrusion, suggesting a role during conoid movements. Furthermore, our data capture the parasites in the act of secretion during conoid protrusion.
Modular and practical diamination of allenes
Authors: Dai Jian-Jun , Yin Xianglin , Li Lei , Rivera Mario E. , Wang Ye-Cheng , Dai Mingji 
Published: March 2023

AbstractVicinal diamines are privileged scaffolds in medicine, agrochemicals, catalysis, and other fields. While significant advancements have been made in diamination of olefins, diamination of allenes is only sporadically explored. Furthermore, direct incorporation of acyclic and cyclic alkyl amines onto unsaturated π systems is highly desirable and important, but problematic for many previously reported amination reactions including the diamination of olefins. Herein, we report a modular and practical diamination of allenes, which offers efficient syntheses of β,γ-diamino carboxylates and sulfones. This reaction features broad substrate scope, excellent functional group tolerability, and scalability. Experimental and computational studies support an ionic reaction pathway initiated with a nucleophilic addition of the in situ formed iodoamine to the electron deficient allene substrate. An iodoamine activation mode via a halogen bond with a chloride ion was revealed to substantially increase the nucleophilicity of the iodoamine and lower the activation energy barrier for the nucleophilic addition step.
Hydrovoltaic effect-enhanced photocatalysis by polyacrylic acid/cobaltous oxide–nitrogen doped carbon system for efficient photocatalytic water splitting
Authors: Xin Xu , Zhang Youzi , Wang Ruiling , Wang Yijin , Guo Peng , Li Xuanhua 
Published: March 2023

AbstractSevere carrier recombination and the slow kinetics of water splitting for photocatalysts hamper their efficient application. Herein, we propose a hydrovoltaic effect-enhanced photocatalytic system in which polyacrylic acid (PAA) and cobaltous oxide (CoO)–nitrogen doped carbon (NC) achieve an enhanced hydrovoltaic effect and CoO–NC acts as a photocatalyst to generate H2 and H2O2 products simultaneously. In this system, called PAA/CoO–NC, the Schottky barrier height between CoO and the NC interface decreases by 33% due to the hydrovoltaic effect. Moreover, the hydrovoltaic effect induced by H+ carrier diffusion in the system generates a strong interaction between H+ ions and the reaction centers of PAA/CoO–NC, improving the kinetics of water splitting in electron transport and species reaction. PAA/CoO–NC exhibits excellent photocatalytic performance, with H2 and H2O2 production rates of 48.4 and 20.4 mmol g−1 h−1, respectively, paving a new way for efficient photocatalyst system construction.
Virome-wide detection of natural infection events and the associated antibody dynamics using longitudinal highly-multiplexed serology
Authors: Kelley Erin J. , Henson Sierra N. , Rahee Fatima , Boyle Annalee S. , Engelbrektson Anna L. , Nelson Georgia A. , Mead Heather L. , Anderson N. Leigh , Razavi Morteza , Yip Richard , Ladner Jason T. , Scriba Thomas J. , Altin John A. 
Published: March 2023

AbstractCurrent methods for detecting infections either require a sample collected from an actively infected site, are limited in the number of agents they can query, and/or yield no information on the immune response. Here we present an approach that uses temporally coordinated changes in highly-multiplexed antibody measurements from longitudinal blood samples to monitor infection events at sub-species resolution across the human virome. In a longitudinally-sampled cohort of South African adolescents representing >100 person-years, we identify >650 events across 48 virus species and observe strong epidemic effects, including high-incidence waves ofAichivirus Aand the D68 subtype ofEnterovirus Dearlier than their widespread circulation was appreciated. In separate cohorts of adults who were sampled at higher frequency using self-collected dried blood spots, we show that such events temporally correlate with symptoms and transient inflammatory biomarker elevations, and observe the responding antibodies to persist for periods ranging from ≤1 week to >5 years. Our approach generates a rich view of viral/host dynamics, supporting novel studies in immunology and epidemiology.
Widespread detection of chlorine oxyacids in the Arctic atmosphere
Authors: Tham Yee Jun , Sarnela Nina , Iyer Siddharth , Li Qinyi , Angot Hélène , Quéléver Lauriane L. J. , Beck Ivo , Laurila Tiia , Beck Lisa J. , Boyer Matthew , Carmona-García Javier , Borrego-Sánchez Ana , Roca-Sanjuán Daniel , Peräkylä Otso , Thakur Roseline C. , He Xu-Cheng , Zha Qiaozhi , Howard Dean , Blomquist Byron , Archer Stephen D. , Bariteau Ludovic , Posman Kevin , Hueber Jacques , Helmig Detlev , Jacobi Hans-Werner , Junninen Heikki , Kulmala Markku , Mahajan Anoop S. , Massling Andreas , Skov Henrik , Sipilä Mikko , Francisco Joseph S. , Schmale Julia , Jokinen Tuija , Saiz-Lopez Alfonso 
Published: March 2023

AbstractChlorine radicals are strong atmospheric oxidants known to play an important role in the depletion of surface ozone and the degradation of methane in the Arctic troposphere. Initial oxidation processes of chlorine produce chlorine oxides, and it has been speculated that the final oxidation steps lead to the formation of chloric (HClO3) and perchloric (HClO4) acids, although these two species have not been detected in the atmosphere. Here, we present atmospheric observations of gas-phase HClO3 and HClO4. Significant levels of HClO3 were observed during springtime at Greenland (Villum Research Station), Ny-Ålesund research station and over the central Arctic Ocean, on-board research vessel Polarstern during the Multidisciplinary drifting Observatory for the Study of the Arctic Climate (MOSAiC) campaign, with estimated concentrations up to 7 × 106 molecule cm−3. The increase in HClO3, concomitantly with that in HClO4, was linked to the increase in bromine levels. These observations indicated that bromine chemistry enhances the formation of OClO, which is subsequently oxidized into HClO3 and HClO4 by hydroxyl radicals. HClO3 and HClO4 are not photoactive and therefore their loss through heterogeneous uptake on aerosol and snow surfaces can function as a previously missing atmospheric sink for reactive chlorine, thereby reducing the chlorine-driven oxidation capacity in the Arctic boundary layer. Our study reveals additional chlorine species in the atmosphere, providing further insights into atmospheric chlorine cycling in the polar environment.
Well-defined double hysteresis loop in NaNbO3 antiferroelectrics
Authors: Luo Nengneng , Ma Li , Luo Gengguang , Xu Chao , Rao Lixiang , Chen Zhengu , Cen Zhenyong , Feng Qin , Chen Xiyong , Toyohisa Fujita , Zhu Ye , Hong Jiawang , Li Jing-Feng , Zhang Shujun 
Published: March 2023

AbstractAntiferroelectrics (AFEs) are promising candidates in energy-storage capacitors, electrocaloric solid-cooling, and displacement transducers. As an actively studied lead-free antiferroelectric (AFE) material, NaNbO3 has long suffered from its ferroelectric (FE)-like polarization-electric field (P-E) hysteresis loops with high remnant polarization and large hysteresis. Guided by theoretical calculations, a new strategy of reducing the oxygen octahedral tilting angle is proposed to stabilize the AFE P phase (Space group Pbma) of NaNbO3. To validate this, we judiciously introduced CaHfO3 with a low Goldschmidt tolerance factor and AgNbO3 with a low electronegativity difference into NaNbO3, the decreased cation displacements and [BO6] octahedral tilting angles were confirmed by Synchrotron X-ray powder diffraction and aberration-corrected scanning transmission electron microscopy. Of particular importance is that the 0.75NaNbO3−0.20AgNbO3−0.05CaHfO3 ceramic exhibits highly reversible phase transition between the AFE and FE states, showing well-defined double P-E loops and sprout-shaped strain-electric field curves with reduced hysteresis, low remnant polarization, high AFE-FE phase transition field, and zero negative strain. Our work provides a new strategy for designing NaNbO3-based AFE material with well-defined double P-E loops, which can also be extended to discover a variety of new lead-free AFEs.
Anomalous quantized plateaus in two-dimensional electron gas with gate confinement
Authors: Yan Jiaojie , Wu Yijia , Yuan Shuai , Liu Xiao , Pfeiffer L. N. , West K. W. , Liu Yang , Fu Hailong , Xie X. C. , Lin Xi 
Published: March 2023

AbstractQuantum information can be coded by the topologically protected edges of fractional quantum Hall (FQH) states. Investigation on FQH edges in the hope of searching and utilizing non-Abelian statistics has been a focused challenge for years. Manipulating the edges, e.g. to bring edges close to each other or to separate edges spatially, is a common and essential step for such studies. The FQH edge structures in a confined region are typically presupposed to be the same as that in the open region in analysis of experimental results, but whether they remain unchanged with extra confinement is obscure. In this work, we present a series of unexpected plateaus in a confined single-layer two-dimensional electron gas (2DEG), which are quantized at anomalous fractions such as 9/4, 17/11, 16/13 and the reported 3/2. We explain all the plateaus by assuming surprisingly larger filling factors in the confined region. Our findings enrich the understanding of edge states in the confined region and in the applications of gate manipulation, which is crucial for the experiments with quantum point contact and interferometer.
Strong variation of spin-orbit torques with relative spin relaxation rates in ferrimagnets
Authors: Zhu Lijun , Ralph Daniel C. 
Published: March 2023

AbstractSpin-orbit torques (SOTs) have been widely understood as an interfacial transfer of spin that is independent of the bulk properties of the magnetic layer. Here, we report that SOTs acting on ferrimagnetic FexTb1-x layers decrease and vanish upon approaching the magnetic compensation point because the rate of spin transfer to the magnetization becomes much slower than the rate of spin relaxation into the crystal lattice due to spin-orbit scattering. These results indicate that the relative rates of competing spin relaxation processes within magnetic layers play a critical role in determining the strength of SOTs, which provides a unified understanding for the diverse and even seemingly puzzling SOT phenomena in ferromagnetic and compensated systems. Our work indicates that spin-orbit scattering within the magnet should be minimized for efficient SOT devices. We also find that the interfacial spin-mixing conductance of interfaces of ferrimagnetic alloys (such as FexTb1-x) is as large as that of 3d ferromagnets and insensitive to the degree of magnetic compensation.