bluuebunny/crossref_metadata_2025_split huggingface dataset:
Report on the earthquake in Turkey: Field observation on healthcare services and ethical challenges
Authors: Değer Mehmet Sait , Özdinç Ahmet 
Published: September 2023

On February 6, 2023, an earthquake with a magnitude of 7.7 m occurred in Turkey, centered in the Pazarcık district of Kahramanmaraş province, followed nine hours later by another earthquake with a magnitude of 7.6 m, centered in the Elbistan district of Kahramanmaraş province. In the earthquakes, 45,000 people died, and more than 100,000 were injured. During the earthquake search-and-rescue personnel, emergency responders, and volunteers worked in the field. Disasters that suddenly affect large masses of people create many issues related to medical ethics. Likewise, difficulties caused by limited resources lead to issues related to beneficence, non-maleficence, autonomy and justice. This is a descriptive research study based on the field observations of researchers who were actually in the disaster area after the earthquakes, as well as an analysis of and observations related to the news, information and reports published. This study draws attention to ensuring the participation of society in the fight against and response to disasters. In addition, ethical guidelines for healthcare providers in disasters should be prepared and integrated into national disaster plans. Turkey’s earthquake experience will provide essential information for decision-makers and practitioners regarding the extent of the area impacted and the scope of the affected population.
Bangladesh Journal of Medical Science Vol. 22 No. 04 October’23 Page :815-826
Pelatihan Teknik Self Control untuk Mengurangi Penggunaan Gadget pada Anak Usia Dini
Authors: Anggraini Henni , Emmanuel Sarah 
Published: September 2023

Generasi Alpha merupakan generasi milenial yang sangat akrab dalam penggunaan teknologi. Kebutuhan akan teknologi tidak bisa terpisahkan dari generasi mereka. Berdasarkan hasil wawancara yang dilakukan kepada guru dan orang tua peserta didik di PAUD Tunas Bangsa Krebet Bululawang. Para peserta didik di PAUD tersebut sudah mulai mengenal gadget sejak usia dua tahun. Tujuan penggunaan gadget oleh orang tua selain untuk belajar namun juga untuk mengalihkan perhatian anak dan agar lebih tenang ketika orang tua melakukan aktivitas sehingga tidak mengganggu kegiatan orang tua mereka. Untuk mencegah kecanduan gadget pada anak melalui pelatihan self control ini diharapkan orang tua memahami dan memiliki kemampuan melakukan kontrol diri terhadap anak mereka melalui pendampingan dan pengawasan selama penggunaan gadget di rumah. Kegiatan Pelatihan kami lakukan di PAUD Tunas Bangsa Bululawang yang diikuti oleh guru dan orang tua murid di PAUD Tunas Bangsa Krebet Bululawang sebanyak 24 peserta. Pada pelatihan Teknik self control ini peserta yaitu guru dan orang tua dapat memahami serta menerapkan teknik self control tersebut sesuai dengan permasalahan yang dialami peserta didik di PAUD Tunas Bangsa Krebet Bululawang.
Optimalisasi Peran Dan Fungsi BUMDes Astaguna Dalam Pengembangan Ekonomi Masyarakat Desa Trihanggo
Authors: Aji Juhari Sasmito , Retnaningdiah Dian , Hayati Kemala 
Published: September 2023

Provinsi Daerah Istimewa Yogyakarta memiliki potensi unggul di berbagai desa yang ditandai dengan terbentuknya lembaga ekonomi BUMDes yang harus dikembangkan. Mitra Program Kemitraan Masyarakat (PKM) ini adalah BUMDes Astaguna yang berada di Desa Trihanggo. Bidang dan tata kelola yang ada dikelompok ini belum mampu mewujudkan tujuan yang diharapkan termasuk sektor perekonomian. Hal tersebut dilatarbelakangi dengan permasalahan yang dihadapi mitra yakni minimnyanya kualitas sumberdaya manusia yang tidak memiliki pengetahuan (intangible) yang cakap terkait pengelolaan BUMDes, rendahnya bidang manajemen unit usaha ditunjukkan dengan tidak adanya keselarasan identifikasi potensi, dan tidak adanya penerapan teknologi informasi komunikasi pada bidang pemasaran. Tujuan kegiatan diupayakan untuk mencapai perbaikan di bidang sumberdaya manusia, manajemen unit usaha, dan penerapan teknologi informasi dan komunikasi. Solusi yang ingin dicapai yakni menerapkan tata kelola yang baik sesuai dengan prinsip good governance dengan kesiapan kualitas sumberdaya manusia yang optimal dan cakap terkait pengetauan pengelolaan sehingga menjadi jelas terkait tugas pokok fungsi dan koordinasi kerja internal badan. Manajemen unit usaha dengan mewujudkan unit usaha baru sesuai analisis potensi dan asset desa disertai pelibatan masyarakat. Penerapan teknologi informasi komunikasi untuk mendukung produktifitas program dan kegiatan yang meliputi bidang administrasi dan bidang pemasaran guna menunjang sumberdaya manusia agar mencapai melek teknologi.
Pelatihan Macrame Sebagai Peningkatan Ketrampilan Masyarakat RT 01 RW 10 Kelurahan Merjosari, Kota Malang
Authors: Nindyawati Nindyawati , Karyadi Karyadi , Sulton Muhammad , Santoso Edi , Efendi Maskur 
Published: September 2023

Kelurahan Merjosari memiliki penduduk sebanyak 17.842 jiwa pada Tahun 2020 dengan mata pencaharian penduduk kelurahan Merjosari adalah Pegawai Negeri Sipil, TNI/POLRI, karyawan swasta, wiraswasta atau pedagang, tani, pertukangan, buruh tani, dan jasa. Data Badan Pusat Statistik Kota Malang menyampaikan bahwa penganguran sebesar 9,65% dari jumlah usia produktif. Dari data yang diperoleh dapat ditarik kesimpulan bahwa masyarakat belum diberdayakan secara maksimal. Dengan menambah ketrampilan SDM yang ada diharapkan akan meningkatkan kemampuan secara finansial. Jumlah KK di RT 1 RW 10 Kelurahan Merjosari adalah sebanyak 47 keluarga. Beberapa ibu yang dapat mengikuti kegiatan pelatihan adalah 10 orang. Pelatihan diberikan oleh pemateri pengrajin Macrame. Peserta diberikan pengetahuan membuat Macrame untuk simpul yang umum digunakan. Pada saat pelatihan, peserta diberi tali dan benang Macrame masing-masing satu paket. Berdasarkan pelatihan dengan bimbingan pemateri yang telah dilakukan, para peserta pelatihan memulai menganyam benang penggantung pot dan gantungan kunci. Hasil dari kerajinan dapat dibawa pulang untuk contoh apabila akan memperbanyak dan dijual. Kerajinan Macrame dapat dibuat di rumah dan di sela-sela kegiatan ibu-ibu rumah tangga. Selanjutnya penjualan dilakukan menggunakan social media, sehingga sangat flexible untuk ibu-ibu rumah tangga ataupun ibu-ibu pekerja.
Hybrid deep modeling of a CHO-K1 fed-batch process: combining first-principles with deep neural networks
Authors: Pinto José , Ramos João R. C. , Costa Rafael S. , Rossell Sergio , Dumas Patrick , Oliveira Rui 
Published: September 2023

Introduction: Hybrid modeling combining First-Principles with machine learning is becoming a pivotal methodology for Biopharma 4.0 enactment. Chinese Hamster Ovary (CHO) cells, being the workhorse for industrial glycoproteins production, have been the object of several hybrid modeling studies. Most previous studies pursued a shallow hybrid modeling approach based on three-layered Feedforward Neural Networks (FFNNs) combined with macroscopic material balance equations. Only recently, the hybrid modeling field is incorporating deep learning into its framework with significant gains in descriptive and predictive power.Methods: This study compares, for the first time, deep and shallow hybrid modeling in a CHO process development context. Data of 24 fed-batch cultivations of a CHO-K1 cell line expressing a target glycoprotein, comprising 30 measured state variables over time, were used to compare both methodologies. Hybrid models with varying FFNN depths (3-5 layers) were systematically compared using two training methodologies. The classical training is based on the Levenberg-Marquardt algorithm, indirect sensitivity equations and cross-validation. The deep learning is based on the Adaptive Moment Estimation Method (ADAM), stochastic regularization and semidirect sensitivity equations.Results and conclusion: The results point to a systematic generalization improvement of deep hybrid models over shallow hybrid models. Overall, the training and testing errors decreased by 14.0% and 23.6% respectively when applying the deep methodology. The Central Processing Unit (CPU) time for training the deep hybrid model increased by 31.6% mainly due to the higher FFNN complexity. The final deep hybrid model is shown to predict the dynamics of the 30 state variables within the error bounds in every test experiment. Notably, the deep hybrid model could predict the metabolic shifts in key metabolites (e.g., lactate, ammonium, glutamine and glutamate) in the test experiments. We expect deep hybrid modeling to accelerate the deployment of high-fidelity digital twins in the biopharma sector in the near future.
Effects of fatigue on the in vivo kinematics and kinetics of talocrural and subtalar joint during landing
Authors: Luo Ye , Li Zhuman , Hu Mengling , Zhang Ling , Li Feng , Wang Shaobai 
Published: September 2023

Objective: Fatigue can affect the ankle kinematic characteristics of landing movements. Traditional marker-based motion capture techniques have difficulty in accurately obtaining the kinematics of the talocrural and subtalar joints. This study aimed to investigate the effects of fatigue on the talocrural and subtalar joints during the landing using dual fluoroscopic imaging system (DFIS).Methods: This study included fourteen healthy participants. The foot of each participant was scanned using magnetic resonance imaging to create 3D models. High-speed DFIS was used to capture images of the ankle joint during participants performing a single-leg landing jump from a height of 40 cm. Fatigue was induced by running and fluoroscopic images were captured before and after fatigue. Kinematic data were obtained by 3D/2D registration in virtual environment software. The joint kinematics in six degrees of freedom and range of motion (ROM) were compared between the unfatigued and fatigued conditions.Results: During landing, after the initial contact with the ground, the main movement of the talocrural joint is extension and abduction, while the subtalar joint mainly performs extension, eversion, and abduction. Compared to unfatigued, during fatigue the maximum medial translation (1.35 ± 0.45 mm vs. 1.86 ± 0.69 mm, p = 0.032) and medial-lateral ROM (3.19 ± 0.60 mm vs. 3.89 ± 0.96 mm, p = 0.029) of the talocrural joint significantly increased, the maximum flexion angle (0.83 ± 1.24° vs. 2.11 ± 1.80°, p = 0.037) of the subtalar joint significantly increased, and the flexion-extension ROM (6.17 ± 2.21° vs. 7.97 ± 2.52°, p = 0.043) of the subtalar joint significantly increased.Conclusion: This study contributes to the quantitative understanding of the normal function of the talocrural and subtalar joints during high-demand activities. During landing, the main movement of the talocrural joint is extension and abduction, while the subtalar joint mainly performs extension, eversion, and abduction. Under fatigue conditions, the partial ROM of the talocrural and subtalar joints increases.
Sick building syndrome and its associated factors among adult people living in Hodan district Moqadishu Somalia
Authors: Yussuf Saed M. , Dahir Gallad , Salad Abdi M. , Hayir T. M Mohamud , Hassan Shafie Abdulkadir , Gele Abdi 
Published: September 2023

Background: Sick building syndrome (SBS) consists of a group of mucosal, skin, and general symptoms temporally that is related to residential buildings of unclear causes. Consequently, a cross-sectional study was carried out to identify the prevalence and contributing factors of SBS in adult people living in Hodan district, Mogadishu Somalia.Methods: A community based cross sectional study was conducted from September to October 2022 using a convenient sampling to include 261 individuals. The data was collected through structured questionnaire and an observational checklist. SBS was assessed using 15 building-related symptoms and four socio-demographic characteristics. Five SBS conformation criteria were used. Descriptive statistics were presented, while bivariate and multivariate logistic regression analyses were conducted to assess the association between the dependent and independent variables.Results: The prevalence of SBS was 41% from the total of 261 participants. Based on the findings, SBS had a significant association with being female [AOR = 3.044, 95% CI = (1.813, 5.110)], lack of functional windows [AOR = 3.543, 95% CI = (1.293, 9.710)], fungal growth in the buildings [AOR = 3.433, 95% CI = (1.223, 9.638)], recent use of pesticides, paints, and solvents [AOR = 2.541, 95% CI = (1.018, 6.343)], cooking inside building [AOR = 4.709, 95% CI = (1.469, 15.095)], outdoor air pollutant [AOR = 6.364, 95% CI = (2.387, 16.966)], use of charcoal for cooking [AOR = 1.846, 95% CI = (1.013, 3.365)], incensing habits of occupants [AOR = 4.375, 95% CI = (2.303, 8.308)] fan use [AOR = 2.067, 95% CI = (1.099, 3.886)] and dust in the living rooms [AOR = 5.151, 95% CI = (2.380, 11.152).Conclusion: SBS had a significant association with occupants’ sex, lack of functional windows, fungal growth in the buildings, recent use of pesticides, paints, and solvents, cooking inside the building, outdoor air pollutants, use of charcoal for cooking, incensing habits of occupants, and dust in the living rooms. High prevalence and poor understanding of sick building syndrome could threaten the health status of the occupants. Measures such as mass health education on identifiable risk factors should be taken to cope with these problems.
Extracellular vesicles promote activation of pro-inflammatory cancer-associated fibroblasts in oral cancer
Authors: Arebro Julia , Towle Rebecca , Lee Che-Min , Bennewith Kevin L. , Garnis Cathie 
Published: September 2023

Introduction: Oral squamous cell carcinoma (OSCC) is the most common form of head and neck cancer and has a survival rate of ∼50% over 5 years. New treatment strategies are sorely needed to improve survival rates—and a better understanding of the mechanisms underlying tumorigenesis is needed to develop these strategies. The role of the tumor microenvironment (TME) has increasingly been identified as crucial in tumor progression and metastasis. One of the main constituents of the TME, cancer-associated fibroblasts (CAFs), plays a key role in influencing the biological behavior of tumors. Multiple mechanisms contribute to CAF activation, such as TGFβ signaling, but the role of extracellular vesicles (EVs) in CAF activation in OSCC is poorly understood. Assessing the impact of oral cancer-derived EVs on CAF activation will help to better illuminate OSCC pathophysiology and may drive development of novel treatments options.Methods: EVs were isolated from OSCC cell lines (Cal 27, SCC-9, SCC-25) using differential centrifugation. Nanoparticle tracking analysis was used for EV characterization, and Western blot to confirm the presence of EV protein markers. Oral fibroblasts were co-cultured with enriched EVs, TGFβ, or PBS over 72 h to assess activation. Flow cytometry was used to evaluate CAF markers. RNA collected from fibroblasts was extracted and the transcriptome was sequenced. Conditioned media from the co-cultures was evaluated with cytokine array profiling.Results: OSCC-derived EVs can activate oral fibroblasts into CAFs that are different from those activated by TGFβ, suggesting different mechanisms of activation and different functional properties. Gene set enrichment analysis showed several upregulated inflammatory pathways in those CAFs exposed to OSCC-derived EVs. Marker genes for inflammatory CAF subtypes were also upregulated, but not in CAFs activated by TGFβ. Finally, cytokine array analysis on secreted proteins revealed elevated levels of several pro-inflammatory cytokines from EV-activated CAFs, for instance IL-8 and CXCL5.Discussion: Our results reveal the ability of OSCC-derived EVs to activate fibroblasts into CAFs. These CAFs seem to have unique properties, differing from TGFβ-activated CAFs. Gaining an understanding of the interplay between EVs and stromal cells such as CAFs could lead to further insights into OSCC tumorigenesis and potential novel therapeutics.
3D porous polymers for selective removal of CO2 and H2 storage: experimental and computational studies
Authors: Al-Bukhari Muath S. , Abdulazeez Ismail , Abdelnaby Mahmoud M. , Aljundi Isam H. , Al Hamouz Othman Charles S. 
Published: September 2023

In this article, newly designed 3D porous polymers with tuned porosity were synthesized by the polycondensation of tetrakis (4-aminophenyl) methane with pyrrole to form M1 polymer and with phenazine to form M2 polymer. The polymerization reaction used p-formaldehyde as a linker and nitric acid as a catalyst. The newly designed 3D porous polymers showed permanent porosity with a BET surface area of 575 m2/g for M1 and 389 m2/g for M2. The structure and thermal stability were investigated by solid 13C-NMR spectroscopy, Fourier-transform infrared (FT-IR) spectroscopy, and thermogravimetric analysis (TGA). The performance of the synthesized polymers toward CO2 and H2 was evaluated, demonstrating adsorption capacities of 1.85 mmol/g and 2.10 mmol/g for CO2 by M1 and M2, respectively. The importance of the synthesized polymers lies in their selectivity for CO2 capture, with CO2/N2 selectivity of 43 and 51 for M1 and M2, respectively. M1 and M2 polymers showed their capability for hydrogen storage with a capacity of 66 cm3/g (0.6 wt%) and 87 cm3/g (0.8 wt%), respectively, at 1 bar and 77 K. Molecular dynamics (MD) simulations using the grand canonical Monte Carlo (GCMC) method revealed the presence of considerable microporosity on M2, making it highly selective to CO2. The exceptional removal capabilities, combined with the high thermal stability and microporosity, enable M2 to be a potential material for flue gas purification and hydrogen storage.
Impact of premature coronary artery disease on adverse event risk following first percutaneous coronary intervention
Authors: Pinxterhuis Tineke H. , Ploumen Eline H. , Zocca Paolo , Doggen Carine J. M. , Schotborgh Carl E. , Anthonio Rutger L. , Roguin Ariel , Danse Peter W. , Benit Edouard , Aminian Adel , Hartmann Marc , Linssen Gerard C. M. , von Birgelen Clemens 
Published: September 2023

ObjectivesWe assessed differences in risk profile and 3-year outcome between patients undergoing percutaneous coronary intervention (PCI) for premature and non-premature coronary artery disease (CAD).BackgroundThe prevalence of CAD increases with age, yet some individuals develop obstructive CAD at younger age.MethodsAmong participants in four randomized all-comers PCI trials, without previous coronary revascularization or myocardial infarction (MI), we compared patients with premature (men &lt;50 years; women &lt;55 years) and non-premature CAD. Various clinical endpoints were assessed, including multivariate analyses.ResultsOf 6,171 patients, 887(14.4%) suffered from premature CAD. These patients had fewer risk factors than patients with non-premature CAD, but were more often smokers (60.7% vs. 26.4%) and overweight (76.2% vs. 69.8%). In addition, premature CAD patients presented more often with ST-segment elevation MI and underwent less often treatment of multiple vessels, and calcified or bifurcated lesions. Furthermore, premature CAD patients had a lower all-cause mortality risk (adj.HR:0.23, 95%-CI: 0.10–0.52; p &lt; 0.001), but target vessel revascularization (adj.HR:1.63, 95%-CI: 1.18–2.26; p = 0.003) and definite stent thrombosis risks (adj.HR:2.24, 95%-CI: 1.06–4.72; p = 0.034) were higher. MACE rates showed no statistically significant difference (6.6% vs. 9.4%; adj.HR:0.86, 95%-CI: 0.65–1.16; p = 0.33).ConclusionsAbout one out of seven PCI patients was treated for premature CAD. These patients had less complex risk profiles than patients with non-premature CAD; yet, their risk of repeated revascularization and stent thrombosis was higher. As lifetime event risk of patients with premature CAD is known to be particularly high, further efforts should be made to improve modifiable risk factors such as smoking and overweight.Clinical Trial Registration[clinicaltrials.gov], TWENTE [NCT01066650]; DUTCH PEERS [NCT01331707]; BIO-RESORT [NCT01674803]; BIONYX [NCT02508714].
Accelerated stenotic flow in the left anterior descending coronary artery explains the causes of impaired coronary flow reserve: an integrated transthoracic enhanced Doppler study
Authors: Caiati Carlo , Pollice Paolo , Iacovelli Fortunato , Sturdà Francesca , Lepera Mario Erminio 
Published: September 2023

BackgroundAccelerated stenotic flow (AsF) in the entire left anterior descending coronary artery (LAD), assessed by transthoracic enhanced color Doppler (E-Doppler TTE), can reveal coronary stenosis (CS) and its severity, enabling a distinction between the microcirculatory and epicardial causes of coronary flow reserve (CFR) impairment.MethodsEighty-four consecutive patients with a CFR &lt;2.0 (1.5 ± 0.4), as assessed by E-Doppler TTE, scheduled for coronary angiography (CA) and eventually intracoronary ultrasounds (IVUS), were studied. CFR was calculated by the ratio of peak diastolic flow velocities: during i.v. adenosine (140 mcg/Kg/m) over resting; AsF was calculated as the percentage increase of localized maximal velocity in relation to a reference velocity.ResultsCA showed ≥50% lumen diameter narrowing of the LAD (critical CS) in 68% of patients (57/84) vs. non-critical CS in 32% (27/84). Based on the established CA/IVUS criteria, the non-critical CS subgroup was further subdivided into 2 groups: subcritical/diffuse [16/27 pts (57%)] and no atherosclerosis [11/27 pts (43%)]. CFR was similar in the three groups: 1.4 ± 0.3 in critical CS, 1.5 ± 0.4 in subcritical/diffuse CS, and 1.6 ± 0.4 in no atherosclerosis (p = ns). Overall, at least one segment of accelerated stenotic flow in the LAD was found in 73 patients (87%), while in 11 (13%) it was not. The AsF was very predictive of coronary segmental narrowing in both angio subgroups of atherosclerosis but as expected with the usage of different cutoffs. On the basis of the ROC curve, the optimal cutoff was 109% and 16% AsF % increment to successfully distinguish critical from non-critical CS (area under the curve [AUC] = 0.99, p &lt; 0.001) and diffuse/subcritical from no CS (AUC = 0.91%, p &lt; 0.001). Sensitivity and specificity were 96% and 100% and 82% and 100%, respectively.ConclusionE-Doppler TTE is highly feasible and reliable in detecting the CS of any grade of severity, distinguishing epicardial athero from microvascular causes of a severe CFR reduction.