bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antioxidative and Anticancer Potential of Luteolin: A Comprehensive Approach Against Wide Range of Human Malignancies
Authors: Mahwish  , Imran Muhammad , Naeem Hammad , Hussain Muzzamal , Alsagaby Suliman A. , Al Abdulmonem Waleed , Mujtaba Ahmed , Abdelgawad Mohamed A. , Ghoneim Mohammed M. , El‐Ghorab Ahmed H. , Selim Samy , Al Jaouni Soad K. , Mostafa Ehab M. , Yehuala Tadesse Fenta 
Published: January 2025

ABSTRACTLuteolin is widely distributed phytochemical, a flavonoid, in kingdom plantae. Luteolin with potential antioxidant activity prevent ROS‐induced damages and reduce oxidative stress which is mainly responsible in pathogenesis of many diseases. Several chemo preventive activities and therapeutic benefits are associated with luteolin. Luteolin prevents cancer via modulation of numerous pathways, that is, by inactivating proteins; such as procaspase‐9, CDC2 and cyclin B or upregulation of caspase‐9 and caspase‐3, cytochrome C, cyclin A, CDK2, and APAF‐1, in turn inducing cell cycle arrest as well as apoptosis. It also enhances phosphorylation of p53 and expression level of p53‐targeted downstream gene. By Increasing BAX protein expression; decreasing VEGF and Bcl‐2 expression it can initiate cell cycle arrest and apoptosis. Luteolin can stimulate mitochondrial‐modulated functions to cause cellular death. It can also reduce expression levels of p‐Akt, p‐EGFR, p‐Erk1/2, and p‐STAT3. Luteolin plays positive role against cardiovascular disorders by improving cardiac function, decreasing the release of inflammatory cytokines and cardiac enzymes, prevention of cardiac fibrosis and hypertrophy; enhances level of CTGF, TGFβ1, ANP, Nox2, Nox4 gene expressions. Meanwhile suppresses TGFβ1 expression and phosphorylation of JNK. Luteolin helps fight diabetes via inhibition of alpha‐glucosidase and ChE activity. It can reduce activity levels of catalase, superoxide dismutase, and GS4. It can improve blood glucose, insulin, HOMA‐IR, and HbA1c levels. This review is an attempt to elaborate molecular targets of luteolin and its role in modulating irregularities in cellular pathways to overcome severe outcomes during diseases including cancer, cardiovascular disorders, diabetes, obesity, inflammation, Alzheimer's disease, Parkinson's disease, hepatic disorders, renal disorders, brain injury, and asthma. As luteolin has enormous therapeutic benefits, it could be a potential candidate in future drug development strategies.
Ellagic Acid Modulates Necroptosis, Autophagy, Inflammations, and Stress to Ameliorate Nonalcoholic Liver Fatty Disease in a Rat Model
Authors: Li Zhuoheng , Li Juan , He Shuli , Chen Jun , Deng Chengjun , Duan Jintao 
Published: January 2025

ABSTRACTNonalcoholic fatty liver disease (NAFLD) is considered one of the most common metabolic disorders worldwide. Although the pathoetiology of NAFLD is not fully elucidated, recent evidence suggests the involvement of stress, inflammation, and programmed death in the onset and progression of the disease. This investigation aimed to evaluate the effects of ellagic acid (EA), a known herbal antioxidant, on a high‐fat diet (HFD)‐induced animal model of NAFLD by evaluating the status of lipid profile, necroptosis (RIPK1, RIPK3, and MLKL), autophagy (LC3, ATG5, and BECN1), inflammation (TNF‐α, IL‐6, IL‐4, and IL‐10), and stress (SOD, CAT, GR, GPx, and MDA). In this regard, rats were randomly divided into 6 groups as follows: normal diet controls, HFD (supplemented with high caloric diet model), EA low dose (HFD and 10 mg/kg/day EA), EA middle dose (HFD and 25 mg/kg/day EA), EA high dose (HFD and 50 mg/kg/day EA), and Rosiglitazone (HFD and 10 mg/kg/day Rosi). After the treatment, the levels of markers related to necroptosis and autophagy in the liver tissue as well as the lipid profiles, inflammation, and oxidative stress status were analyzed. It was shown that the dose of EA was able to improve the weight gain and lipid profile when compared to NAFLD animals (p‐value < 0.001). Moreover, EA increased the level of LC3 and ATG5 while decreasing BECN 1, RIPK1, RIPK3, and MLKL compared to the HFD‐induced NAFLD rats (p‐value < 0.05). TNF‐α and IL‐6 were decreased after EA administration, whereas IL‐4 and IL‐10 levels were increased (p‐value < 0.001). Furthermore, the increase in the activity of SOD, CAT, GR, and GPx along with the decrease in MDA levels indicated the suppression of oxidative stress by EA treatment compared to the NAFLD rats (p‐value < 0.0001). The current findings may suggest that EA improves NAFLD via modulation of necroptosis, autophagy, inflammation, and stress.
Improvement of Iron and β‐Carotene Bioaccessibility in Complementary Foods: Biofortification of Local Crops With Organic Residual Products and Microorganisms
Authors: Thiam Mbeugué , Diouf Adama , Icard‐Vernière Christèle , Avallone Sylvie , Ndiaye Ndèye Fatou , De Souza Marielle Atala , Médoc Jean‐Michel , Idohou‐Dossou Nicole , Humblot Christèle 
Published: January 2025

ABSTRACTMicronutrient deficiencies remain a great public health challenge worldwide with iron, zinc, and vitamin A being the most problematic. It has been shown that biofortification through agronomic strategies can increase their micronutrient content, but data on the bioavailability remain limited. In Senegal, consumption of cereals and legumes is high, and orange‐fleshed sweet potato (OFSP), rich in β‐carotene, has been introduced a decade ago. The objective of the present work was to assess the bioaccessibility of iron, zinc, and β‐carotene in local complementary foods prepared with millet, cowpea, and OFSP alone or in combination, produced using different agronomic biofortification strategies. Organic residual products were used alone or in combination with microorganisms to produce the abovementioned crops that were used to prepare the complementary foods. Static in vitro digestion was performed to assess the bioaccessibility of the micronutrients, according to a harmonized protocol. The two organic residual products had different effect, as the cow dung alone was inefficient to increase iron and zinc contents as well as their bioaccessibility in millet porridges. However, the use of poultry litter alone or in combination with microorganisms increased iron bioaccessibility in cooked cowpea (27%–29%) compared to the non‐biofortified counterpart (9%). Surprisingly, bioaccessible β‐carotene was significantly higher (4.1%) in sample of mashed OFSP biofortified with the combination of the different agronomic strategies than in the others (1.4%–2.5%). Portions (150 g) of porridge prepared from the three biofortified crops would cover up to 100% of the daily vitamin A requirements of children aged 6–23 months. The use of a combination the most promising varieties of crops, together with the agronomic strategies, would be a complementary approach to sustainability limit micronutrient deficiencies in a context of monotonous diets.
An Intersectional Perspective on Cyberbullying: Victimization Experiences Among Marginalized Youth
Authors: Amadori Alberto , Real André Gonzales , Brighi Antonella , Russell Stephen T. 
Published: January 2025

ABSTRACTIntroductionThe impact of cyberbullying victimization on youth development, encompassing mental health, academic performance, and socioemotional well‐being, has been widely documented. Research highlights the heightened vulnerability of sexual and gender minoritized youth, along with other youth from marginalized groups, to cybervictimization. However, there is a gap in understanding how intersecting marginalized social identities affect experiences of cyberbullying.MethodsThis study employs an intersectionality framework to examine cybervictimization among youth. The sample consists of 444,224 students in grades 9–12 from the 2017–2019 California Healthy Kids Survey. Using exhaustive chi‐square automatic interaction detection (ECHAID), the analysis identifies the prevalence of cybervictimization across multiple intersecting social identities, including sex assigned at birth, gender modality (cisgender 97.6%), sexual orientation, race/ethnicity, grade level, and socioeconomic status.ResultsCybervictimization was reported by 22.7% of youth in the sample. Rates were two to three times higher among youth with multiple marginalized identities. Youth at the intersection of bisexual sexual orientation, transgender gender modality, and racial/ethnic minoritized identities faced a particularly high risk of cybervictimization.ConclusionsThere is an urgent need for future research in cyberbullying and youth development. Such research should focus on identifying and understanding the intersectional nature of discrimination and victimization, both in‐person and online, to develop evidence‐based prevention programs that effectively address the complexities of minoritized identities and discrimination in the digital world.
Productive and Unproductive Effort Choices in Groups and Sharing: An Experimental Study
Authors: Büyükboyacı Mürüvvet , Karagözoğlu Emin , Küçükşenel Serkan 
Published: January 2025

ABSTRACTAgents in collaborative relationships (e.g., business partnership and co‐authorship) frequently need to decide on the allocation of limited resources (e.g., time and money) to productive activities that increase the size of the joint surplus and unproductive, promotional activities that do not affect the size of the surplus but increase their (individual) likelihood of capturing a greater control/share of the surplus. Using a laboratory experiment, we first analyze the effect of the opportunity cost of unproductive investment on subjects' resource allocation decisions in the first stage. Second, we study whether (i) the opportunity cost of unproductive investment and (ii) the identity of the decision‐maker (human or computer) affect subjects' distributive decisions in the second stage. Three main insights emerge from our experiment: First, we find that subjects choose productive and unproductive investments equally likely both in low and high opportunity cost treatments. Second, subjects give less to their matched pairs if they choose unproductive investment in human treatment but not in computer treatment that suggests that subjects punish (by giving less) their matched pairs for allocating more resources to unproductive, promotional activities, a behavior that is not present when the allocation decision is made by a computer.
A review of the mechanical property, durability, and modification of carbon‐ and glass‐fiber reinforced polyurethane composites
Authors: Han Wei , Zhou Ping , Xie Siwei , Li Chenggao , Xian Guijun , Dong Shaoce 
Published: January 2025

AbstractCarbon‐ and glass‐fiber reinforced polyurethane (CFRPU/GFRPU) composites gained worldwide industrial applications because of the versatility of the PU matrix. The present study summarized the mechanical performance, durability, and modification of CFRPU/GFRPU composites. Results show that the mechanical performance of CFRPU/GFRPU composites depends on the manufacturing and test parameters. CFRPU/GFRPU composites have similar durable performance compared with their epoxy‐based counterpart composites. The degradation of CFRPU/GFRPU composites under exposures depends on the competition between positive effects like post‐curing and side effects including matrix swelling, plasticization, and hydrolysis as well as interface debonding. The maximum improvement rates of the tensile strength, interfacial strength, flexural strength, and impact strength of CFRPU/GFRPU composites could reach 53.2%, 154.5%, 50.3%, and 170% depending on different modifications. More attention should be paid to the durability of CFRPU/GFRPU composites under combined effects of environment and loads, and modification of continuous glass‐ or carbon‐fiber reinforced polyurethane composites regarding improving their mechanical and durable performance.
Drought Response in the Transcriptome and Ionome of Wild and Domesticated Lablab purpureus L. Sweet, an Underutilized Legume
Authors: Kolesnikova Anastasia , Hammond John , Chapman Mark A. 
Published: January 2025

ABSTRACTHunger remains a prevalent issue worldwide, and with a changing climate, it is expected to become an even greater problem that our food systems are not adapted to. There is therefore a need to investigate strategies to fortify our foods and food systems. Underutilized crops are farmed regionally, are often adapted to stresses, including droughts, and have great nutritional profiles, potentially being key for food security. One of these crops, Lablab purpureus L Sweet, or lablab, is a legume grown for humans or as fodder and shows remarkable drought tolerance. Understanding of lablab's molecular responses to drought and drought's effects on its nutritional qualities is limited and affects breeding potential. Using transcriptomics at three time points, changes in gene expression in response to drought were investigated in wild and domesticated lablab. The effect of drought on the elemental profile of lablab leaves was investigated using ionomics to assess drought's impact on nutritional quality. Differences in drought response between wild and domesticated lablab accessions were revealed, which were mainly due to differences in the expression of genes related to phosphorus metabolic response, cell wall organization, and cellular signaling. The leaves of wild and domesticated lablab accessions differed significantly in their elemental concentrations, with wild accessions having higher protein, zinc, and iron concentrations. Drought affected the concentration of some elements, with potential implications for the use of lablab under different environments. Overall, this study is an important first step in understanding drought response in lablab with implications for breeding and improvement of drought‐tolerant lablab.
Effect of treatment on mechanical and thermal properties of date palm fibers/polyvinyl chloride composites
Authors: Boussehel Hamida , Ghelani Laala , Guerira Belhi , Bezazi Abderrezak , Reis P. N. B. , Alothman Othman Y. , Jawaid Mohammad 
Published: January 2025

AbstractThis study investigates the incorporation of date palm fibers, an abundant agricultural waste, into polyvinyl chloride (PVC) composites at a 25% fiber weight ratio. Alkali treatment, potassium permanganate oxidation, and silane coupling were applied to enhance fiber‐matrix adhesion. The composites were fabricated using a hot pressing method. The results revealed significant improvements in mechanical, thermal, and moisture resistance properties for treated fibers compared to untreated ones. Potassium permanganate treatment achieved the highest tensile strength 9.57 MPa, while alkali treatment provided the highest Young's modulus about 304.5 MPa and thermal stability. Silane‐treated composites exhibited the lowest water absorption. X‐ray diffraction analysis showed that chemical treatments improved the crystallinity index (CI) of date palm fibers, with alkali treatment increasing CI from 28.6% to 40.5%, and potassium permanganate and silane treatments raising it to 37.5% and 41.8%, respectively. These findings highlight the potential of treated date palm fiber composites as sustainable alternatives for industrial applications such as construction and automotive, aligning with both economic and environmental objectives.Highlights
Enhanced PVC composites using date palm fibers.
Alkali, permanganate, and silane treatments improve mechanical properties.
Permanganate treatment achieves the highest tensile strength.
Reduced water absorption and improved thermal stability in treated composites.
Sustainable application of agricultural waste in industrial materials.
A Fixed-Point Result in Banach Spaces from Divided Differences
Authors: Ezquerro J. A. , Hernández-Verón M. A. 
Published: January 2025

Abstract
We present a new fixed point result in Banach spaces by using divided differences of first order and auxiliary points to obtain a result of the so-called restricted fixed point. In particular, we use the secant method to draw conclusions about the fixed point and the domain where it is located, so that we obtain global convergence of the secant method to approximate the fixed point with superlinear speed of convergence.
Optimal timing of stabilization and operative technique for extremity fractures in polytrauma patients: a systematic review and meta-analysis
Authors: Steinfeld Eva , Horst Klemens , Ansems Kelly , Dahms Karolina , Dormann Julia , Janka Heidrun , Inti-Metzendorf Maria , Benstoem Carina , Hildebrand Frank , Becker Nils 
Published: January 2025

Abstract

Purpose
In polytrauma patients, injuries involving the extremities are frequently seen. Treatment concepts vary from early definitive care to temporary fixation and delayed definite stabilization. This analysis therefor aims to illuminate the impact of timing for operative stabilization of extremity fractures on outcome factors in adult polytrauma patients.

Methods
We searched PubMed and Cochrane CENTRAL to identify studies from inception of each database to 14 September 2022. We included systematic reviews and RCTs comparing immediate versus delayed operative fracture stabilization and early definite care versus primary external fixation in adult polytrauma patients.

Results
Five randomized controlled trials were included, with a total of 335 patients. The analysis found no statistically significant difference in overall mortality or improvement in ICU admission between early (< 24 h) and late fracture stabilization. Comparing femoral nailing and external fixation, findings showed that femoral nailing reduce ICU length of stay and duration of invasive mechanical ventilation.

Conclusion
The results indicate that immediate surgical treatment by nailing is superior to delayed treatment or a staged surgical approach in stable polytrauma patients with long-bone fractures. As there is a lack of clear evidence regarding the optimal timing for definitive operative stabilization of extremity fractures in polytrauma patients, further high-quality studies are essential to enhance the certainty of evidence and provide more conclusive treatment algorithms.
What do the voice-related parameters tell us? The multiparametric index scores, cepstral-based methods, patient-reported outcomes, and durational measurements
Authors: Gölaç Hakan , Gülaçtı Adnan , Atalık Güzide , Çabuk Gözde Bayramoğlu , Yılmaz Metin 
Published: January 2025

Abstract

Purpose
This study aimed to identify how the acoustic parameters, patient-reported outcomes (PROs), and durational measurements differ based on perceptually rated dysphonia severity and to investigate their relationship with dysphonia severity.

Methods
One hundred seventy-nine subjects (males-78, females-101; mean ± SD age of 47.79 ± 14.05 years) with various etiology of dysphonia were included in this prospective cohort study. The G parameter of GRBAS was used to rate dysphonia severity. The Acoustic Voice Quality Index (AVQI v. 03.01), Acoustic Breathiness Index (ABI), and cepstral peak prominence-smoothed (CPPS) values for sustained vowel (CPPSsv) and connected speech (CPPScs) samples were obtained using the Praat software. The Voice Handicap Index-10 (VHI-10) and Voice-Related Quality of Life (V-RQOL) were used for PROs, and the maximum phonation time (MPT) and s/z ratio were measured as durational parameters.

Results
The acoustic parameters, including AVQI and ABI scores, and CPPSsv and CPPScs values significantly differed based on dysphonia severity, particularly in those with moderate (G2) or severe dysphonia (G3) compared to those with normal (G0) and/or slightly deviated (G1) voice. Among the PROs, VHI-10 scores significantly differed only between the groups G1 and G2 (p < 0.005) and the groups G1 and G3 (p < 0.005), whilst there were not any significant differences between the V-RQOL scores of all the compared groups. Significant differences were observed within the groups for MPT, but the s/z ratio significantly differed only between the groups G1 and G3. Correlation analysis revealed significant relationships between the G parameter of GRBAS and all measured variables (p < 0.001).

Conclusions
Particular attention should be paid to the AVQI and ABI scores, CPPsv and CPPcs values, VHI-10 scores, and MPT values since they provide valuable information for overall dysphonia severity.
iForensic, multicentric validation of digital whole slide images (WSI) in forensic histopathology setting according to the College of American Pathologists guidelines
Authors: Pigaiani Nicola , Oliva Antonio , Cirielli Vito , Grassi Simone , Arena Vincenzo , Solari Luca-Maria , Tatriele Naomi , Raniero Dario , Brunelli Matteo , Gobbo Stefano , Scarpa Aldo , Pantanowitz Liron , Rodegher Pamela , Bortolotti Federica , Ausania Francesco 
Published: January 2025

Abstract
Pathology has benefited from the rapid progress of image-digitizing technology during the last decade. However, the application of digital whole slide images (WSI) in forensic pathology still needs to be improved. WSI validation is crucial to ensure diagnostic performance, at least equivalent to glass slides and light microscopy. The College of American Pathologists Pathology and Laboratory Quality Center recently updated internal digital pathology system validation recommendations. Following these guidelines, this pilot study aimed to validate the performance of a digital approach for forensic histopathological diagnosis. Six independent skilled forensic pathologists from different forensic medicine institutes evaluated 100 glass slides of forensic interest (80 stained with standard hematoxylin and eosin, 20 with special staining), including different organs and tissues, with light microscopy (Olympus BX51, Tokyo, Japan). Glass slides were scanned using the Aperio GT 450 DX Digital Slides Scanner (Leica Biosystems, Nussloch, Germany). After two wash-out weeks, forensic pathologists evaluated WSIs in front of a widescreen using computer devices with dedicated software (O3 viewer, O3 Enterprise, Zucchetti, Trieste, Italy). Side-by-side comparisons between diagnoses performed on tissue glass slides versus WSIs were above the threshold stated in the validation guidelines (mean concordance of 97.8%). CSUQ Version 3 questionnaire showed high satisfaction for all pathologists (mean result: 6.6/7). Our institutional digital forensic pathology system has been validated for practical casework application. This approach opens new scenarios in practical forensic casework investigations, such as sharing live histological ex-glass slides online, as well as educational and research perspectives, with improving impacts on the whole daily workflow.