bluuebunny/crossref_metadata_2025_split huggingface dataset:
DHEERA reaching the young, a novel approach addressing gender‐based violence in India
Authors: Kumari S. Shantha , Suman B. Aruna , Kiranmai D. , Bhardwaj Ajey 
Published: September 2023

AbstractObjectiveTo understand, build capacities, give guidance, and support school‐going adolescent boys and girls on gender stereotypes and violence against women (VAW) and to assess the role of educational training in improving knowledge, attitudes, and practice to stop VAW.MethodsAn educational interventional study was conducted for a period of 18 months across schools in India, involving boys and girls studying in grades 9–12. Assessment of the program's effectiveness on influencing young minds in breaking the taboos surrounding gender stereotypes and stopping VAW was completed through a pre‐test and post‐test, consisting of 12 scenario‐based questions.ResultsIn all, 8931 participants (64% girls and 36% boys) from 26 states in India submitted their pre‐test, post‐test, and feedback forms. Participants showed improved clarity and comprehension on issues surrounding VAW/gender‐based violence. There was a significant improvement in the knowledge on what actions can be taken and whom to approach for cases related to VAW/gender‐based violence. The post‐test survey showed a high level of commitment to overcoming gender stereotyping and stopping VAW.ConclusionThis unique nationwide study demonstrated the effectiveness of an educational intervention that led to improved knowledge, attitude, and commitment towards stopping VAW. A large‐scale program can be self‐sustaining when it is embedded in the schools responsible for shaping young minds.
Research on evolution process of full‐layer incision of skin tissue under different laser incidences
Authors: Chen Yuxin , Huang Jun , Wang Kehong , Li Xiaopeng , Rui Yunfeng , Fan Wentao 
Published: September 2023

AbstractConsidering difficulties of achieving vertical incidence of beam in different positions of skin, it is significant to study potential effects of incidence angles of laser on incisions. Surgical platform with a 1064 nm continuous fiber laser was established. Incident angle was adopted and real‐time temperature fluctuations in laser operating area could be monitored. The rats were treated with laser at day 0 and day 3 after incision modeling, and H&E, Masson, Sirius Red, and Immuno‐histochemical staining and enzyme‐linked immunosorbent assay were adopted at day 3, 7, 14 to analyze the performance of healing. Laser with energy density of 67.54 J/mm2 can effectively accelerate wound healing in vivo, in which a laser with incident angle around 60° can effectively avoid scar hyperplasia. Therefore, the use of low energy laser with a small deflection angle has a good clinical application prospect in promoting wound healing.
Self‐consistent field method for open‐shell systems within the density‐matrix functional theory
Authors: Irimia Marinela , Wang Jian 
Published: September 2023

AbstractThe unrestricted Hartree‐Fock method is extended to correlation calculation within the density‐matrix functional theory. The method is derived from an entropic cumulant functional for the correlation energy. The eigenvalue equations for the spin‐orbitals are modified by the orbital occupation numbers. The Euler equation for the occupation numbers results in the Fermi‐Dirac distribution, which is very efficient to update as soon as the orbital eigenvalue equations are solved. The method is demonstrated on the ground state of O.
Multisite MRI Intravoxel Incoherent Motion Repeatability and Reproducibility across 3 T Scanners in a Breast Diffusion Phantom: A BReast Intravoxel Incoherent Motion Multisite (BRIMM) Study
Authors: Basukala Dibash , Mikheev Artem , Sevilimedu Varadan , Gilani Nima , Moy Linda , Pinker Katja , Thakur Sunitha B. , Sigmund Eric E. 
Published: September 2023

BackgroundMonoexponential apparent diffusion coefficient (ADC) and biexponential intravoxel incoherent motion (IVIM) analysis of diffusion‐weighted imaging is helpful in the characterization of breast tumors. However, repeatability/reproducibility studies across scanners and across sites are scarce.PurposeTo evaluate the repeatability and reproducibility of ADC and IVIM parameters (tissue diffusivity (Dt), perfusion fraction (Fp) and pseudo‐diffusion (Dp)) within and across sites employing MRI scanners from different vendors utilizing 16‐channel breast array coils in a breast diffusion phantom.Study TypePhantom repeatability.PhantomA breast phantom containing tubes of different polyvinylpyrrolidone (PVP) concentrations, water, fat, and sponge flow chambers, together with an MR‐compatible liquid crystal (LC) thermometer.Field Strength/SequenceBipolar gradient twice‐refocused spin echo sequence and monopolar gradient single spin echo sequence at 3 T.AssessmentStudies were performed twice in each of two scanners, located at different sites, on each of 2 days, resulting in four studies per scanner. ADCs of the PVP and water were normalized to the vendor‐provided calibrated values at the temperature indicated by the LC thermometer for repeatability/reproducibility comparisons.Statistical TestsADC and IVIM repeatability and reproducibility within and across sites were estimated via the within‐system coefficient of variation (wCV). Pearson correlation coefficient (r) was also computed between IVIM metrics and flow speed. A P value <0.05 was considered statistically significant.ResultsADC and Dt demonstrated excellent repeatability (<2%; <3%, respectively) and reproducibility (both <5%) at the two sites. Fp and Dp exhibited good repeatability (mean of two sites 3.67% and 5.59%, respectively) and moderate reproducibility (mean of two sites 15.96% and 13.3%, respectively). The mean intersite reproducibility (%) of Fp/Dp/Dt was 50.96/13.68/5.59, respectively. Fp and Dt demonstrated high correlations with flow speed while Dp showed lower correlations. Fp correlations with flow speed were significant at both sites.Data ConclusionIVIM reproducibility results were promising and similar to ADC, particularly for Dt. The results were reproducible within both sites, and a progressive trend toward reproducibility across sites except for Fp.Level of Evidence2Technical EfficacyStage 1
Impact of in‐season split application of nitrogen on intra‐panicle grain dynamics, grain quality, and vegetative indices that govern nitrogen use efficiency in sorghum
Authors: Ostmeyer Troy J. , Impa Somayanda M. , Bean Scott R. , Dhillon Rajveer , Hayes Chad , Ritchie Glen , Asebedo Antonio R. , Emendack Yves , Jagadish S. V. Krishna 
Published: September 2023

AbstractBackgroundThe correct rate and timing of nitrogen (N) has the potential to improve sorghum productivity through modified grain yield components and quality. The impacts of in‐season split application of N have little documentation.AimAn experiment was conducted to determine the optimum rate and timing of N to relate vegetative indices that govern nitrogen use efficiency and to maximize grain yield and quality under different soil types.MethodsPioneer 86P20 was grown in three environments on two different soil types following a completely randomized block design with nine N application treatments. Treatments included differing N rates applied at critical developmental stages of sorghum (planting, panicle initiation, and booting), accompanied with high temporal aerial phenotyping.ResultsOpportunities to increase grain protein content while using split N applications were observed, with panicle initiation identified as a critical developmental stage. In‐season split application of N enhances grain yield under low soil mineral N. Split application of 31 kg N ha−1 each at the time of planting, panicle initiation, and booting emerged as optimum N treatment to increase protein content in sorghum. Vegetative indices, that is, normalized difference vegetation index and normalized difference red edge index are capable of predicting grain yield and protein content, respectively. Intra‐panicle grain numbers and weights were altered significantly at different portions within panicles, with an opportunity to enhance yield potential at the bottom portion. The strong stay‐green trait in this hybrid locked a large proportion of nitrogen in the leaves, which warrants the need for balancing stay‐green and senescence in sorghum improvement programs.ConclusionsFindings highlight that in grain sorghum remobilization of residual leaf N into grain is a target to increase yield and grain quality. An optimized stay‐green trait balanced with senescence is recommended for enhancing sorghum yield potential.
Synergistic relationships between the age of soil organic matter, Fe speciation, and aggregate stability in an arable Luvisol
Authors: Siebers Nina , Voggenreiter Eva , Joshi Prachi , Rethemeyer Janet , Wang Liming 
Published: September 2023

AbstractBackgroundKnowledge of soil aggregate formation and stability is essential, as this is important for maintaining soil functions.AimsThis study aimed to investigate the influence of organic matter (OM), the content of pedogenic iron (Fe) (oxyhydr)oxides, and aggregate size on the stability of aggregates in arable soil.MethodsTo this end, the Ap and Bt horizons of a Luvisol were sampled after 14 years of bare fallow, and the results were compared with a control field that had been permanently cropped.ResultsIn the Ap horizon, bare fallow decreased the median diameter of the 53–250 µm size fraction by 26%. Simultaneously, the mass of the 20–53 µm size fraction increased by 65%, indicating reduced stability—particularly of larger soil microaggregates—due to the lack of input of fresh OM. The range of 14carbon (14C) fraction of modern C (F14C) under bare fallow was between 0.50 and 0.90, and thus lower than the cropped site (F14C between 0.75 and 1.01), which is particularly pronounced in the smallest size fraction, indicating the presence of older C. This higher stability and the reduced C turnover in <20 µm aggregates is probably also due to having the highest content of poorly crystalline Fe (oxy)hydroxides, compared to the other size fractions, which act as a cementing agent. Colloid transport from the Ap to the Bt horizon was observed under bare fallow treatment.ConclusionsThe lack of input of OM decreased the stability of microaggregates and led to a release of mobile colloids, the transport of which can initiate elemental fluxes with as‐yet unknown environmental consequences.
How to plan and manage an individual participant data meta‐analysis. An illustrative toolkit
Authors: Maxwell Lauren , Shreedhar Priya , Carabali Mabel , Levis Brooke 
Published: September 2023

AbstractIndividual participant data meta‐analyses (IPD‐MAs) have several benefits over standard aggregate data meta‐analyses, including the consideration of additional participants, follow‐up time, and the joint consideration of study‐ and participant‐level heterogeneity for improved diagnostic and prognostic model development and evaluation. However, IPD‐MAs are resource‐intensive and require careful budgeting of time from data contributing groups, a dedicated management team, diversity of expertise, clearly documented data sharing and authorship agreements, and consistent and clear communication. We present a toolkit to facilitate the implementation and management of IPD‐MAs, from study recruitment to retrospective harmonization. The toolkit was developed and refined over our work on multiple multinational IPD‐MA projects over the last 13 years. The toolkit's budget and email templates, agreements, project management spreadsheets, and standard operating procedures are meant to facilitate routine IPD‐MA tasks to expedite implementing and managing future IPD‐MA projects.
Sexual assault characteristics and posttraumatic stress symptoms among collegiate women: The role of posttraumatic cognitions
Authors: Newins Amie R. , Wilson Laura C. 
Published: September 2023

AbstractAlthough it is well‐established that sexual assault is a risk factor for posttraumatic stress symptoms (PTSS) and other negative mental health outcomes, research is needed to help identify which individuals are most likely to experience ongoing distress following sexual assault. Negative cognitions following trauma may be influenced by sexual assault characteristics and have been shown to be associated with PTSS. The present study examined whether sexual assault characteristics were associated with PTSS by way of posttraumatic cognitions in a sample of 475 female college students who had experienced a sexual assault since the age of 14 years. Participants completed an online survey that included questions about sexual assault characteristics (i.e., whether the perpetrator used force, whether they experienced a freeze response), posttraumatic cognitions, and PTSS. Path analysis revealed that survivors who indicated they froze during the assault reported higher levels of PTSS, total effect = .28, p < .001, direct effect = .19, p < .001; posttraumatic cognitions regarding others, indirect effect = .02, p = .047, and other‐safety, indirect effect = .05, p = .003, partially accounted for this association. Only the direct effect of perpetrator use of force on PTSS was statistically significant, total effect = .23, p = .090, direct effect = .16, p = .009; none of the indirect effects were statistically significant, ps = .063–.669. The results support that assault characteristics are associated with postassault outcomes and are consistent with the cognitive model of posttraumatic stress disorder.
Body‐and movement‐oriented interventions for posttraumatic stress disorder: An updated systematic review and meta‐analysis
Authors: van de Kamp Minke M. , Scheffers Mia , Emck Claudia , Fokker Ties J. , Hatzmann Janneke , Cuijpers Pim , Beek Peter J. 
Published: September 2023

AbstractThis study is an update of the meta‐analysis we published in 2019 on the effectiveness of body‐ and movement‐oriented interventions (BMOIs) for adults with posttraumatic stress disorder (PTSD) in decreasing PTSD symptoms and secondary outcomes of depressive symptoms, sleep disturbance, and interoceptive awareness. Search terms for BMOIs and PTSD were combined to identify eligible studies in four bibliographical databases. Articles were selected if they included adult participants with a primary diagnosis of PTSD, included BMOI as one of the investigated therapies, were designed as a comparative outcome trial with any control condition, and involved a standardized outcome measure for PTSD symptom severity. This resulted in the addition of 14 new studies compared to the 2019 study. The meta‐analysis, which included 29 studies in total, resulted in a mean Hedges’ g effect size of 0.50, 95% CI [0.22, 0.79], in decreasing PTSD symptoms, with very high heterogeneity, I2 = 89%. Meta‐analyses of secondary outcomes resulted in Hedges’ g effect sizes of 0.37, 95% CI [0.08, 0.66] for depressive symptoms; 0.62, 95% CI [0.42, 0.81] for sleep quality; and −0.10, 95% CI [−0.23, 0.43] for interoceptive awareness. The risk of bias analysis resulted in some concerns or high risk of bias in almost all included studies; only one study had a low risk of bias. We conclude that BMOIs may be valuable for patients with PTSD. There is, however, still a lack of high‐quality studies with proper control conditions and long‐term follow‐up periods from which to draw conclusions.
Northern bobwhite breeding season and nest survival are greater on native grasslands
Authors: Sinnott Emily A. , Thompson Frank R. , Hedges R. Kyle , Loncarich Frank L. , Thompson Thomas R. , Mosloff Alisha R. 
Published: September 2023

AbstractNorthern bobwhites (Colinus virginianus) are declining across their range. Population recovery requires a better understanding of the influence of management strategies and land cover on specific demographic components of full annual cycle population dynamics. We used known‐fate daily survival models to relate adult breeding season survival and nest survival to land cover composition, woody cover, and management actions on 5 study sites in southwest Missouri, USA. We collected 3,516 observations of daily nest survival from 364 bobwhite nests for 7,509 exposure days and 34,386 observations of adult survival from 955 bobwhites for 85,225 exposure days during breeding seasons in 2014–2018. The most supported model for nest and adult breeding season survival included environmental covariates for percent native grass and agricultural cover, distance to shrub, and distance to tree. Both nest and adult breeding season survival were positively related to distance to trees. Nest survival was negatively related to percent agricultural crop cover. Areal nest and adult breeding season survival were greater on native grassland sites compared to conservation areas that maintained small units of strip crop and wooded cover. Management to sustain or expand native grass cover and reduce tree cover should benefit bobwhite nest survival and adult breeding season survival in the landscapes we studied.
Mechanism of DYRK1a in myocardial ischemia–reperfusion injury by regulating ferroptosis of cardiomyocytes
Authors: Wang Jing , Xu Rui‐Ming , Cao Qiu‐Mei , Ma Bing‐Chen , Zhang Hao , Hao Hua‐Peng 
Published: September 2023

AbstractThis study aimed to explore the role and mechanism of DYRK1a regulating ferroptosis of cardiomyocytes during myocardial ischemia–reperfusion injury (MIRI). H9c2 cells treated with oxygen–glucose deprivation/reoxygenation (OGD/R) were used as MIRI cell models and transfected with sh‐DYRK1a or/and erastin. Cell viability, apoptosis, and DYRK1a mRNA/protein expression were measured accordingly. The levels of reactive oxygen species (ROS), iron, malondialdehyde (MDA), and glutathione (GSH) were determined. The expression of ferroptosis‐related proteins (GPX4, SLC7A11, ACSL4, and TFR1) was detected using western blotting. The MIRI rat model was established to explore the possible role of DYRK1a suppression in cell injury and ferroptosis. OGD/R cells showed elevated mRNA and protein expression for DYRK1a. OGD/R cells transfected with sh‐DYRK1a showed elevated cell viability, GSH content, increased GPX4 and SLC7A11 expression, suppressed iron content, MDA, ROS, ACSL4, and TFR1 expression, and reduced apoptosis rate, whereas co‐transfection of sh‐DYRK1a with erastin reversed the attenuation of sh‐DYRK1a on MIRI. The suppressive effect of sh‐DYRK1a on MI/R injury was confirmed in an MIRI rat model. DYRK1a mediates ferroptosis of cardiomyocytes to deteriorate MIRI progression.
Characteristics of cabozantinib treatment in advanced hepatocellular carcinoma
Authors: Nouso Kazuhiro , Shiota Shohei , Fujita Rio , Wakuta Akiko , Kariyama Kazuya , Hiraoka Atsushi , Atsukawa Masanori , Tani Joji , Tada Toshifumi , Matsuo Yu , Nakamura Shinichiro , Tajiri Kazuto , Kaibori Masaki , Hirooka Masashi , Itobayashi Ei , Kakizaki Satoru , Naganuma Atsushi , Ishikawa Toru , Hatanaka Takeshi , Fukunishi Shinya , Tsuji Kunihiko , Kawata Kazuhito , Takaguchi Koichi , Tsutsui Akemi , Ogawa Chikara , Ochi Hironori , Yasuda Satoshi , Toyoda Hidenori , Kumada Takashi ,   the Real‐life Practice Experts for HCC (RELPEC) Study Group and HCC 48 Group (hepatocellular carcinoma experts from 48 clinics in Japan)
Published: September 2023

AbstractBackground and AimCabozantinib is a molecular targeted agent (MTA) used for treatment of advanced hepatocellular carcinoma (HCC). Although its superiority over placebo has been proven, its effectiveness and risk factors in real‐world practice are needed to be elucidated.MethodsThis study retrospectively enrolled 54 advanced HCC patients, who were treated with cabozantinib. The effectiveness of cabozantinib, adverse events (AE) and risk factors for survival was analysed.ResultsMajority of the patients (88.9%) were treated with two or more MTAs before starting cabozantinib and atezolizumab plus bevacizumab was the most prevalent MTA used (59.3%). The median overall survival and progression‐free survival (PFS) were 6.9 and 4.4 months, respectively. The objective response rate and disease control rate were 3.7% and 40.7%, respectively. Grade 3/4 AE occurred in 37.0% of the patients; however, unpredictable AE was not observed. Multivariate analysis revealed that high neutrophil–lymphocyte ratio (NLR, >4) was a risk factor for survival (hazard ratio for death, 2.35; 95% confidence interval [CI], 1.41–4.82; p = 0.020). Moreover, the occurrence of Grade 3/4 AE was a negative risk factor for both survival (hazard ratio for death, 0.36; 95% CI, 0.16–0.83; p = 0.016) and PFS (hazard ratio for disease progression or death, 0.33; 95% CI, 0.15–0.73; p = 0.006). Neither preceding therapy with atezolizumab/bevacizumab nor a reduced starting dose correlated with patient survival.ConclusionsCabozantinib can be used safely in real‐world practice. The study identified high NLR as a positive risk factor and the occurrence of Grade 3/4 AE as a negative risk factor for survival.
Crosslinked Collagen‐Hyaluronic Acid Scaffold Enhances Interleukin‐10 Under Co‐Culture of Macrophages And Adipose‐Derived Stem Cells
Authors: Hausen Moema de Alencar , Moraes Ariana de Souza , Pedrini Flavia , Grabarz Felipe , Camilli José Angelo , Duek Eliana Aparecida de Rezende 
Published: September 2023

AbstractThe skin, the human body's largest organ, possesses a protective barrier that renders it susceptible to various injuries, including burns. Following burn trauma, the inflammatory process triggers both innate and adaptive immune responses, leading to the polarization of macrophages into two distinct phenotypes: the pro‐inflammatory M1 and the anti‐inflammatory M2. This dual response sets the stage for wound healing and subsequent tissue regeneration. Contributing to this transition from M1 to M2 polarization are human adipose‐derived stem cells (ASCs), which employ paracrine signaling and inflammation suppression to enhance the remodeling phase. ASCs, when combined with biocompatible polymers, can be integrated into functional scaffolds. This study introduces an 1‐ethyl‐3‐(3‐dimethylaminopropyl)carbodiimide‐crosslinked (EDC‐crosslinked) collagen‐hyaluronic acid (Col‐HA) scaffold assembled with ASCs, designed as a natural biomaterial device to modulate macrophage behavior in vitro under co‐culture conditions. This innovation aims to improve wound healing processes. The EDC‐crosslinked Col‐HA scaffold favored the release of anti‐inflammatory cytokines by ASCs, which indicated the M2 prevalence. In tissue engineering, a critical objective lies in the development of functional biomaterials capable of guiding specific tissue responses, notably the control of inflammatory processes. Thus, this research not only presents original findings but also points toward a promising avenue within regenerative medicine.