bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improving air quality assessment using physics-inspired deep graph learning
Authors: Li Lianfa , Wang Jinfeng , Franklin Meredith , Yin Qian , Wu Jiajie , Camps-Valls Gustau , Zhu Zhiping , Wang Chengyi , Ge Yong , Reichstein Markus 
Published: September 2023

AbstractExisting methods for fine-scale air quality assessment have significant gaps in their reliability. Purely data-driven methods lack any physically-based mechanisms to simulate the interactive process of air pollution, potentially leading to physically inconsistent or implausible results. Here, we report a hybrid multilevel graph neural network that encodes fluid physics to capture spatial and temporal dynamic characteristics of air pollutants. On a multi-air pollutant test in China, our method consistently improved extrapolation accuracy by an average of 11–22% compared to several baseline machine learning methods, and generated physically consistent spatiotemporal trends of air pollutants at fine spatial and temporal scales.
Development of a 1:1-binding biparatopic anti-TNFR2 antagonist by reducing signaling activity through epitope selection
Authors: Akiba Hiroki , Fujita Junso , Ise Tomoko , Nishiyama Kentaro , Miyata Tomoko , Kato Takayuki , Namba Keiichi , Ohno Hiroaki , Kamada Haruhiko , Nagata Satoshi , Tsumoto Kouhei 
Published: September 2023

AbstractConventional bivalent antibodies against cell surface receptors often initiate unwanted signal transduction by crosslinking two antigen molecules. Biparatopic antibodies (BpAbs) bind to two different epitopes on the same antigen, thus altering crosslinking ability. In this study, we develop BpAbs against tumor necrosis factor receptor 2 (TNFR2), which is an attractive immune checkpoint target. Using different pairs of antibody variable regions specific to topographically distinct TNFR2 epitopes, we successfully regulate the size of BpAb–TNFR2 immunocomplexes to result in controlled agonistic activities. Our series of results indicate that the relative positions of the two epitopes recognized by the BpAb are critical for controlling its signaling activity. One particular antagonist, Bp109-92, binds TNFR2 in a 1:1 manner without unwanted signal transduction, and its structural basis is determined using cryo-electron microscopy. This antagonist suppresses the proliferation of regulatory T cells expressing TNFR2. Therefore, the BpAb format would be useful in designing specific and distinct antibody functions.
Methamphetamine-induced region-specific transcriptomic and epigenetic changes in the brain of male rats
Authors: Miao Benpeng , Xing Xiaoyun , Bazylianska Viktoriia , Madden Pamela , Moszczynska Anna , Zhang Bo 
Published: September 2023

AbstractPsychostimulant methamphetamine (METH) is neurotoxic to the brain and, therefore, its misuse leads to neurological and psychiatric disorders. The gene regulatory network (GRN) response to neurotoxic METH binge remains unclear in most brain regions. Here we examined the effects of binge METH on the GRN in the nucleus accumbens, dentate gyrus, Ammon’s horn, and subventricular zone in male rats. At 24 h after METH, ~16% of genes displayed altered expression and over a quarter of previously open chromatin regions - parts of the genome where genes are typically active - showed shifts in their accessibility. Intriguingly, most changes were unique to each area studied, and independent regulation between transcriptome and chromatin accessibility was observed. Unexpectedly, METH differentially impacted gene activity and chromatin accessibility within the dentate gyrus and Ammon’s horn. Around 70% of the affected chromatin-accessible regions in the rat brain have conserved DNA sequences in the human genome. These regions frequently act as enhancers, ramping up the activity of nearby genes, and contain mutations linked to various neurological conditions. By sketching out the gene regulatory networks associated with binge METH in specific brain regions, our study offers fresh insights into how METH can trigger profound, region-specific molecular shifts.
Space weathering acts strongly on the uppermost surface of Ryugu
Authors: Matsuoka Moe , Kagawa Ei-ichi , Amano Kana , Nakamura Tomoki , Tatsumi Eri , Osawa Takahito , Hiroi Takahiro , Milliken Ralph , Domingue Deborah , Takir Driss , Brunetto Rosario , Barucci Antonella , Kitazato Kohei , Sugita Seiji , Fujioka Yuri , Sasaki Osamu , Kobayashi Shiho , Iwata Takahiro , Morota Tomokatsu , Yokota Yasuhiro , Kouyama Toru , Honda Rie , Kameda Shingo , Cho Yuichiro , Yoshioka Kazuo , Sawada Hirotaka , Hayakawa Masahiko , Sakatani Naoya , Yamada Manabu , Suzuki Hidehiko , Honda Chikatoshi , Ogawa Kazunori , Shirai Kei , Lantz Cateline , Rubino Stefano , Yurimoto Hisayoshi , Noguchi Takaaki , Okazaki Ryuji , Yabuta Hikaru , Naraoka Hiroshi , Sakamoto Kanako , Tachibana Shogo , Yada Toru , Nishimura Masahiro , Nakato Aiko , Miyazaki Akiko , Yogata Kasumi , Abe Masanao , Okada Tatsuaki , Usui Tomohiro , Yoshikawa Makoto , Saiki Takanao , Tanaka Satoshi , Terui Fuyuto , Nakazawa Satoru , Watanabe Sei-ichiro , Tsuda Yuichi 
Published: September 2023

AbstractReturned samples from Cb-type asteroid (162173) Ryugu exhibit very dark spectra in visible and near-infrared ranges, generally consistent with the Hayabusa2 observations. A critical difference is that a structural water absorption of hydrous silicates is around twice as deep in the returned samples compared with those of Ryugu’s surface, suggesting Ryugu surface is more dehydrated. Here we use laboratory experiments data to indicate the spectral differences between returned samples and asteroid surface are best explained if Ryugu surface has (1) higher porosity, (2) larger particle size, and (3) more space-weathered condition, with the last being the most effective. On Ryugu, space weathering by micrometeoroid bombardments promoting dehydration seem to be more effective than that by solar-wind implantation. Extremely homogeneous spectra of the Ryugu’s global surface is in contrast with the heterogeneous S-type asteroid (25143) Itokawa’s spectra, which suggests space weathering has proceeded more rapidly on Cb-type asteroids than S-type asteroids.
Genetic and clinical variables act synergistically to impact neurodevelopmental outcomes in children with single ventricle heart disease
Authors: Miller Thomas A. , Hernandez Edgar J. , Gaynor J. William , Russell Mark W. , Newburger Jane W. , Chung Wendy , Goldmuntz Elizabeth , Cnota James F. , Zyblewski Sinai C. , Mahle William T. , Zak Victor , Ravishankar Chitra , Kaltman Jonathan R. , McCrindle Brian W. , Clarke Shanelle , Votava-Smith Jodie K. , Graham Eric M. , Seed Mike , Rudd Nancy , Bernstein Daniel , Lee Teresa M. , Yandell Mark , Tristani-Firouzi Martin 
Published: September 2023

Abstract
Background
Recent large-scale sequencing efforts have shed light on the genetic contribution to the etiology of congenital heart defects (CHD); however, the relative impact of genetics on clinical outcomes remains less understood. Outcomes analyses using genetics are complicated by the intrinsic severity of the CHD lesion and interactions with conditionally dependent clinical variables.

Methods
Bayesian Networks were applied to describe the intertwined relationships between clinical variables, demography, and genetics in a cohort of children with single ventricle CHD.

Results
As isolated variables, a damaging genetic variant in a gene related to abnormal heart morphology and prolonged ventilator support following stage I palliative surgery increase the probability of having a low Mental Developmental Index (MDI) score at 14 months of age by 1.9- and 5.8-fold, respectively. However, in combination, these variables act synergistically to further increase the probability of a low MDI score by 10-fold. The absence of a damaging variant in a known syndromic CHD gene and a shorter post-operative ventilator support increase the probability of a normal MDI score 1.7- and 2.4-fold, respectively, but in combination increase the probability of a good outcome by 59-fold.

Conclusions
Our analyses suggest a modest genetic contribution to neurodevelopmental outcomes as isolated variables, similar to known clinical predictors. By contrast, genetic, demographic, and clinical variables interact synergistically to markedly impact clinical outcomes. These findings underscore the importance of capturing and quantifying the impact of damaging genomic variants in the context of multiple, conditionally dependent variables, such as pre- and post-operative factors, and demography.
Single-atom infrared emission in doped silicon nanocrystals
Authors: Wang Feilong , Ou Qiongrong , Zhang Shuyu 
Published: September 2023

Silicon can produce strong near- and mid-infrared emission with the first-proposed super-localized single-atom doping model in the absence of phonons. Our results show the TDM2 is increased by ∼1016 at least.
Synthesis and feasibility studies of doping U at Ti site of Y2Ti2O7 as a radioactive waste immobilization matrix
Authors: Gumber Nitin , Shafeeq Muhammed , Gupta Santosh K. , Phatak Rohan , Kumar Goutam Uttam , Kumar Ravi , Pai Rajesh V. 
Published: September 2023

The article summarieses the crystal chemistry of Y2Ti2O7 for the Incorporation of U at Ti site as nuclear waste host matrix for nuclear industry.
Akuter Querschnitt unter Systemtherapie – Radiotherapie oder OP?
Authors: Ujkic Lidija , Sutanto Ricardo , Knöll Peter , Zarghooni Kourosh , Rosenbrock Johannes , Walter Sebastian 
Published: September 2023

Zusammenfassung
Wirbelkörper sind eine der häufigsten Metastasenlokalisationen beim fortgeschrittenen Prostatakarzinom. Einerseits schränken Wirbelsäulenmetastasen durch begleitende Rückenschmerzen die Lebensqualität der Patienten stark ein, andererseits können Sekundärkomplikationen auftreten, die mit schwerwiegenden neurologischen Ausfallerscheinungen und Funktionsverlusten einhergehen. Neben der Schmerzreduktion stellen zum einen die lokale Tumorkontrolle, zum anderen die Wiederherstellung der spinalen Stabilität zentrale Therapieziele dar. Der Stellenwert der Chirurgie, der konventionellen Strahlentherapie und stereotaktischen Strahlentherapie, sowohl alleinstehend als auch kombiniert, wird vor diesem Hintergrund in der Literatur kontrovers diskutiert. Insbesondere der NOMS-Score erweist sich als hilfreiches Tool zur therapeutischen Entscheidungsfindung. Daten zeigen bessere postoperative Patientenoutcomes nach chirurgischer Therapie, sowohl wenn isoliert durchgeführt als auch kombiniert mit der Strahlentherapie, wobei ein Teil der untersuchten Patientenkollektive andere Primaria neben dem Prostatakarzinom miteinschließen. Vergleichsstudien, die speziell im Setting des metastasierten Prostatakarzinoms die Überlegenheit bestimmter Therapien vergleichen, sind rar. Dasselbe gilt in Bezug auf mikrochirurgische Eingriffe an spinalen Metastasen. Die isolierte Strahlentherapie nimmt insbesondere im Setting der Palliation zur Schmerzlinderung ihren Stellenwert ein, wobei ihre Effektivität zahlreich belegt ist. Therapeutisch entscheidungsführend ist die erwartete Lebensprognose der Patienten. Ein multimodaler Therapieansatz ist vor dem Hintergrund des komplexen Patientenkollektivs vonnöten, wobei aktuelle Therapietrends vor dem Hintergrund der Früherkennung spinaler Metastasen großzügiger eine operative Intervention integrieren.
Colon-Hydro-Therapie: Ausleitung von innen
Authors: Karmeli Yesha 
Published: September 2023

SummaryDie Colon-Hydro-Therapie unterstützt Verdauung, Entgiftung sowie nachhaltige Darmgesundheit und basiert auf Darmspülungen, begleitet durch Bauchmassagen, Nährstoff- und Probiotikagaben. Zu den wichtigsten Indikationen zählen chronische Darmstörungen – von Verstopfung und Durchfall bis zu Entzündungen und Keimbesiedelungen –, aber auch Infektanfälligkeit, Allergien, Erschöpfung, Gelenk- und Kopfschmerzen sowie Unterstützung bei Entgiftung, Fasten oder Darmspiegelung. Im vorgestellten Praxisbeispiel verschwanden Verdauungsstörungen und Erschöpfung bei einer Patientin innerhalb von 5 Wochen im Rahmen wöchentlicher Sitzungen.
Risk factors for total laryngectomy associated proximal esophageal stricture formation in head and neck cancer patients
Authors: Schulz Dominik , Koob Isabelle , Pickhard Anja , Schmid Roland M. , Abdelhafez Mohamed 
Published: September 2023

Abstract
Background Development of esophageal strictures is common after the total laryngectomy of head and neck cancer patients. While endoscopic techniques like dilatation by balloon or Salvary bougies are well established, risk factors and pathophysiology for development of refractory strictures are less well understood.
Objective To evaluate risk factors associated with occurrence and recurrence of total-laryngectomy-associated esophageal strictures in head and neck cancer patients.
Methods We analyzed retrospectively a cohort of 170 head and neck squamous cell carcinoma patients, who underwent total laryngectomy between 2007 and 2017. The outcome measure was laryngectomy-associated proximal esophageal stricture needing an endoscopic dilatation by using a balloon or Savary dilators.
Results Of the 170 patients in the cohort, 32 (18.8%) developed strictures. Mean time between surgery and first endoscopic intervention was 24.4 months. Significant predictive factors were age ≥ 65 (p=0.017), nodal status N> 1 (p=0.003), continued alcohol abuse after surgery (p=0.005) and diabetes mellitus (p=0.005). In a subgroup, 17 of 32 patients developed refractory strictures and needed more than three dilatations to relieve dysphagia. Postoperative mean (p=0.016) and maximum (p=0.015) C-reactive protein (CRP) were predictive for refractory strictures.
Conclusion Symptomatic strictures occurred in 18.8% of the cases. Age, nodal status N>1, continued alcohol abuse and diabetes mellitus were predictive factors. For refractory stenosis (>3 dilatations needed) mean and maximum postoperative CRP were predictive. This may indicate that systemic inflammatory response post-surgery is involved in the stricture formation process.
Lewis Acid Catalyzed 4π-Electrocyclization of Donor–Acceptor Stenhouse Adducts
Authors: Kwon Yonghoon , Yoon Seung Hyeon , Park Kye Sung , Kim Jaehee 
Published: September 2023

AbstractLewis acid catalyzed 4π-electrocyclization of Donor–Acceptor Stenhouse Adducts (DASAs) has been developed. By employing catalytic quantities of Dy(OTf)3, a highly efficient transformation of acyclic DASAs into the corresponding cyclized isomers was achieved. Notably, this transformation exhibited exceptional yields, particularly in the case of first generation DASAs. In addition, Lewis acid catalysis enabled one-pot synthesis of the cyclopentenone product from the ‘donor’ and ‘acceptor’ components.
Expedient Synthesis of Superarmed Glycosyl Donors via Oxidative Thioglycosidation of Glycals
Authors: Demchenko Alexei V. , Forsythe Nicholas P. , Mize Emma R. , Kashiwagi Gustavo A. 
Published: September 2023

AbstractSuperarmed glycosyl donors have higher reactivity compared to their perbenzylated armed counterparts. Generally, the 2-O-benzoyl-3,4,6-tri-O-benzyl protecting group pattern gives rise to increased reactivity due to an O-2/O-5 cooperative effect. Despite having a high reactivity profile and applicability in many expeditious strategies for glycan synthesis, regioselective introduction of the superarming protecting group pattern is tedious for most sugar series. Reported herein is a streamlined synthetic route to yield superarmed glycosyl donors of the d-gluco and d-galacto series equipped with an ethylthio, phenylthio, p-tolylthio, benzoxazol-2-ylthio, O-allyl, or O-pentenyl anomeric leaving group. This streamlined approach was made possible due to the refinement of the oxidative thioglycosylation reaction of the respective glucal and galactal precursors. The applicability of this approach to the direct formation of disaccharides is also showcased.
Photo-Induced Electrophilic Aromatic Substitution of Ferric Acyl Nitrene
Authors: Zong Qianshou , Bai Tianwen , Qiu Guanyinsheng , Hou Ming , Zhang Zhide , Lai Xiaojing , Ren Miaofeng 
Published: September 2023

AbstractA photo-induced intramolecular electrophilic aromatic substitution (SEAr) of N-acyloxyamides using FeCl3 in 1,4-dioxane is reported for the synthesis of biologically interesting benzoxazin-3(4H)-ones. It is believed that irradiation with a blue LED facilitates the reaction, serving as a source of energy. The SEAr reaction pathway is ascribed to the electronic effects present in the aryl ring of the substrates. The reaction is also applicable for the synthesis of useful scaffolds possessing a quinolin-2-one core, such as an anticancer reagent and analogues of brexipiprazole and cilostamide.
Novel Synthesis of Pyrido[2,3-b]quinoxaline-3-carboxylate Derivatives via One-Pot Buchwald Amination–Cyclization
Authors: Vanelle Patrice , Hajri Majdi , Khoumeri Omar , Abderrahim Raoudha , Terme Thierry 
Published: September 2023

AbstractA novel series of pyrido[2,3-b]quinoxaline-3-carboxylate derivatives was synthesized in short reaction times and in moderate to good yields by using a palladium catalyst in a one-pot Buchwald amination/cyclization reaction.
Treatment of Granulomatous Mastitis with Half-Yin and Half-Yang Syndrome
Authors: Li Zhikun , Cheng Xufeng , Zhang Wenke , Zhao Huiduo 
Published: September 2023

AbstractGranulomatous mastitis (GM) is a refractory chronic mastitis, which belongs to the category of “acne mammary abscess” and “ulcer” in Traditional Chinese External Medicine. According to yin-yang syndrome differentiation, the disease can be divided into yin syndrome, yang syndrome, and half-yin and half-yang syndrome. Among them, the theories and treatment of yin syndrome and yang syndrome are relatively comprehensive in Traditional Chinese External Medicine. However, the half-yin and half-yang syndrome lacks a specific theoretical elaboration and treatment system, which is a special and complex syndrome of the disease, limiting the improvement of the clinical efficacy of the disease. The core pathogenesis of GM with half-yin and half-yang syndrome is “obstruction of nutritive and defensive phases, and yin-yang obstruction.” The clinical features are local yin syndrome complicated with yang syndrome, and the disease is lingering and difficult to cure. For syndrome differentiation, it is advisable to “attach more importance to the local while less importance to the whole body.” The treatment should be based on the general principle of “eliminating yin and transforming yang.” For the use of herbs, it is recommended to adopt the methods of “the combination of the herbs in cold and warm nature, mainly with herbs in warm nature, attaching more importance to use the herbs with the function of ascending and less to descending.” Finally, restore the normal circulation of qi and blood as well as the balance of yin and yang to achieve the purpose of treatment.
Decentring the English School: challenging the boundaries of Eurocentrism in the work of Adam Watson
Authors: O’Hagan Jacinta 
Published: September 2023

AbstractThere are growing calls to address the Eurocentrism of classical English School (ES) scholarship and to adopt more holistic frameworks of analysis, which include alternative, non-Western forms of international order and interactions with the European international systems. This article investigates Adam Watson’s contribution to ‘decentring’ the ES. Two dimensions of Watson’s work speak to this objective. The first is his development of a more inclusive comparative historical sociological analysis of states-systems. The second is his development of a more generic concept of systems as complex, variegated and shifting relationships of authority, highlighting the prevalence of hierarchy and hegemony in states-systems. However, Watson’s work remains inflected with Eurocentrism in several important respects. These include his narrative of the evolution of the contemporary states-system, which largely remains one of the autonomous development and expansion of Europe, and the limited ways in which his narrative includes the agency, voices and experiences of non-European peoples.
Resisting climate change vulnerability: feminist and decolonial insights
Authors: Weatherill Charlotte Kate 
Published: September 2023

AbstractIn climate politics, understanding and contesting the meaning of vulnerability has proved extremely difficult. On the one hand, it is an increasingly formalised term that means something very specific scientifically and methodologically within the climate change institutions. On the other hand, vulnerability is part of a colonial discursive framework of risk. In this article, I show how contestations into the scientific project have not sufficiently worked to address the colonial geographic imaginaries that underlie the discursive framework of vulnerability. I suggest that bringing together the work of critical adaptation studies (CAS) with critical feminist and decolonial scholarship, such as the counternarratives of the Pacific,offers a way to resist the victimising politics of disposability and also rethink vulnerability as a concept of resistance, relationality and reflexivity.
Understanding customer experience with Vietnamese hotels by analyzing online reviews
Authors: Nguyen Ha Thi Thu , Nguyen Trung Xuan 
Published: September 2023

AbstractOn the post-pandemic recovery green economy track, especially in the hospitality and tourism industry, businesses must accelerate digital transformation and enter the race to increase customer experience. Improving customer experience is critical, and understanding customers’ emotions and needs after using hotel services is crucial. This is why businesses increasingly rely on online customer reviews on booking sites to gain insight into what their customers seek. By understanding their needs and experiences, hotel managers can provide services that meet customer expectations and improve overall service quality. Although online review analysis is meaningful for hotel managers because of its practicality in business operations, a specific model, method, or tool is needed to explore customer emotions. This study proposes a method to analyze customers’ online reviews of Vietnamese hotel services. With a Data set of 20,551 reviews collected from TripAdvisor, the study examines customers’ perceptions of Vietnamese hotel services overall and aspects of hotel services by combining language rules of natural language and inferential statistics. The key findings indicate that customers are most satisfied with the “place” aspect of hotels, with a satisfaction rate of 78%, while the “room” service aspect has the lowest satisfaction rate at 61.3%. These results have recommended that hotel managers in Vietnam prioritize understanding customers’ sentiments and opinions to improve service quality in aspects where satisfaction rates are lower.
In situ spin coater for multimodal grazing incidence x-ray scattering studies
Authors: Coffey Aidan H. , Slack Jonathan , Cornell Earl , Yang Lee L. , Anderson Kevan , Wang Kang , Dou Letian , Zhu Chenhui 
Published: September 2023

We present herein a custom-made, in situ, multimodal spin coater system with an integrated heating stage that can be programmed with spinning and heating recipes and that is coupled with synchrotron-based, grazing-incidence wide- and small-angle x-ray scattering. The spin coating system features an adaptable experimental chamber, with the ability to house multiple ancillary probes such as photoluminescence and visible optical cameras, to allow for true multimodal characterization and correlated data analysis. This system enables monitoring of structural evolutions such as perovskite crystallization and polymer self-assembly across a broad length scale (2 Å–150 nm) with millisecond temporal resolution throughout a complete thin film fabrication process. The use of this spin coating system allows scientists to gain a deeper understanding of temporal processes of a material system, to develop ideal conditions for thin film manufacturing.