bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neurophysiology of predictable unpleasant event processing in pre‐adolescents and early adolescents, part II: Reflex and event‐related potential markers of defensive reactivity and peripheral attention modulation
Authors: Sege Christopher T. , McTeague Lisa M. , Kegley Molly , Shacklewood Curtisha , Halliday Colleen A. , Calhoun Casey D. , Joseph Jane E. , Adams Zachary W. , Hajcak Greg , Danielson Carla Kmett 
Published: April 2023

AbstractThe ability to anticipate and process predictable unpleasant events, while also regulating emotional reactivity, is an adaptive skill. The current article and a companion in this issue test for potential changes in predictable event processing across the childhood‐to‐adolescence transition, a key developmental period for biological systems that support cognitive/ emotional abilities. While the companion article focuses on neurophysiology of predictable event processing itself, the present article examines peripheral emotional response regulation and attention modulation that coincides with event processing. A total of 315 third‐, sixth‐, or ninth‐grade individuals saw 5‐s cues predicting “scary,” “every day,” or uncertain pictures, and here, blink reflexes and brain event‐related potentials (ERPs) elicited by peripheral noise probes are analyzed. During the cue, blink reflexes and probe ERP (P200) amplitudes were increased when the cue predicted scary, compared to everyday, content. After picture onset, reflex enhancement by scary content then disappeared for predictable images, whereas ERP modulation was similar regardless of predictability. Patterns are similar to those in adults and suggest (1) sustained defensive response priming and enhancement of peripheral attention during aversive anticipation, and (2) an ability, even in pre‐adolescents, to downregulate defensive priming while maintaining attentional modulation once an awaited predictable aversive event occurs.
Detection and distribution of the North Atlantic capelin (Mallotus villosus) using environmental DNA—comparison with data from the main fishery management survey
Authors: Pampoulie Christophe , Singh Warsha , Guðnason Kristinn , Bárðarson Birkir , Ólafsdóttir Guðbjörg , Þórarinsson Þorri , Sveinsson Sæmundur , Gíslason Davið 
Published: April 2023

AbstractCapelin (Mallotus villosus) is both an important commercial and ecological resource of the North Atlantic subpolar region. Two decades ago, the stock distribution around Iceland drastically changed. During autumn, which corresponds to the main feeding period, the capelin stock was previously located between the North of Iceland and the Jan Mayen area. Since the beginning of 2000s, the feeding aggregation has been located at the east coast of Greenland, inducing slight changes in the timing and route of the capelin spawning migration along the Icelandic shelf, and therefore in the catches. Changes in the distribution of capelin around Iceland made it both more difficult and expensive to assess the distribution of the stock with current survey methods. Here, we compare environmental DNA (eDNA) data to the acoustic data collected during the autumn monitoring survey, which leads to a preliminary estimation of the stock size. eDNA samples were collected at five different depths and were analyzed both horizontally across latitudes and longitudes and vertically across depth profiles. We detected eDNA in most of the locations where acoustic data detected capelin. Generalized linear models suggested that eDNA concentrations can be used as a proxy for the detection and quantification of capelin. The horizontal distribution of eDNA observed during both years corresponds with the horizontal distribution of capelin registered with the acoustic approach, while the vertical distribution indicated both effects of oceanic currents and diel vertical migration on eDNA detection and quantification.
Recent advances and interfacial challenges in solid‐state electrolytes for rechargeable Li‐air batteries
Authors: Hou Yue , Chen Ze , Zhang Rong , Cui Huilin , Yang Qi , Zhi Chunyi 
Published: April 2023

AbstractAmong the promising batteries for electric vehicles, rechargeable Li‐air (O2) batteries (LABs) have risen keen interest due to their high energy density. However, safety issues of conventional nonaqueous electrolytes remain the bottleneck of practical implementation of LABs. Solid‐state electrolytes (SSEs) with non‐flammable and eco‐friendly properties are expected to alleviate their safety concerns, which have become a research focus in the research field of LABs. Herein, we present a systematic review on the progress of SSEs for rechargeable LABs, mainly focusing on the interfacial issues existing between the SSEs and electrodes. The discussion highlights the challenges and feasible strategies for designing suitable SSEs for LABs.
Less disagreement, better forecasts: Adjusted risk measures in the energy futures market
Authors: Zhang Ning , Gong Yujing , Xue Xiaohan 
Published: April 2023

AbstractThis paper develops a generic adjustment framework to improve in the market risk forecasts of diverse risk forecasting models, which indicates the degree to which risk is under‐ and overestimated. In the context of the energy commodity market, a market in which tail risk management is of crucial importance, the empirical analysis shows that after this adjustment framework is applied, the forecasting performance of various risk models generally improves, as verified by a battery of backtesting methods. Additionally, our method also lessens the risk model disagreement among post‐adjusted risk forecasts.
Focal mu‐opioid receptor activation promotes neuroinflammation and microglial activation in the mesocorticolimbic system: Alterations induced by inflammatory pain
Authors: Cuitavi Javier , Andrés‐Herrera Paula , Meseguer David , Campos‐Jurado Yolanda , Lorente Jesús D. , Caruana Hannah , Hipólito Lucía 
Published: April 2023

AbstractMicroglia participates in the modulation of pain signaling. The activation of microglia is suggested to play an important role in affective disorders that are related to a dysfunction of the mesocorticolimbic system (MCLS) and are commonly associated with chronic pain. Moreover, there is evidence that mu‐opioid receptors (MORs), expressed in the MCLS, are involved in neuroinflammatory events, although the way by which they do it remains to be elucidated. In this study, we propose that MOR pharmacological activation within the MCLS activates and triggers the local release of proinflammatory cytokines and this pattern of activation is impacted by the presence of systemic inflammatory pain. To test this hypothesis, we used in vivo microdialysis coupled with flow cytometry to measure cytokines release in the nucleus accumbens and immunofluorescence of IBA1 in areas of the MCLS on a rat model of inflammatory pain. Interestingly, the treatment with DAMGO, a MOR agonist locally in the nucleus accumbens, triggered the release of the IL1α, IL1β, and IL6 proinflammatory cytokines. Furthermore, MOR pharmacological activation in the ventral tegmental area (VTA) modified the levels of IBA1‐positive cells in the VTA, prefrontal cortex, the nucleus accumbens and the amygdala in a dose‐dependent way, without impacting mechanical nociception. Additionally, MOR blockade in the VTA prevents DAMGO‐induced effects. Finally, we observed that systemic inflammatory pain altered the IBA1 immunostaining derived from MOR activation in the MSCLS. Altogether, our results indicate that the microglia–MOR relationship could be pivotal to unravel some inflammatory pain‐induced comorbidities related to MCLS dysfunction.
Dietary patterns, social determinants, and emotions during COVID‐19 confinement in Panama: An online survey
Authors: Rios Maritza , Subinas Jon , Delgado Celestina , Torres Eliecer , Goodridge Amador , Cubilla‐Batista Idalina 
Published: April 2023

AbstractAimWe aimed to evaluate health and nutrition behaviors among the Panamanian population during the confinement period corresponding to the first wave of the COVID‐19 pandemic.MethodsWe conducted a cross‐sectional study using an online survey for data collection with a total of 2475 participants over the age of 18 using an online survey. We also completed 64 face‐to‐face interviews. After data validation, 1561 surveys were included in the study. Most respondents were women (74.2%) between 18 and 49 years old. Among the respondents, 83.3% had a university education level, and 49.9% reported a monthly family income of fewer than 1000 USD. In addition, more than 50% self‐reported as overweight or obese.ResultsWe identified three dietary patterns: a healthy, a non‐healthy, and a mixed dietary pattern. The respondents with healthy and nonhealthy dietary patterns reported better socioeconomic conditions than participants from the mixed dietary pattern. Individuals with mixed dietary patterns had lower incomes, less education, and higher unemployment rates. Regarding emotions, we found that women experienced more negative emotions, such as fear, worry, and anxiety, during the lockdown period.ConclusionsTaken together, these results indicate that the mobility restriction measures imposed during the COVID‐19 pandemic could have affected dietary patterns by exacerbating existing inequalities. Directing resources toward promoting healthy nutrition strategies with the most significant positive impacts on public health is a priority, especially in critical situations such as the COVID‐19 pandemic.
Fanconi anemia phenotypic and transplant outcomes' associations in Iranian patients
Authors: Ansari Faezeh , Behfar Maryam , Naji Parisa , Darvish Zahra , Rostami Tahereh , Mohseni Rashin , Alimoghaddam Kamran , Salajegheh Pouria , Ahadi Batool , Mardani Mahta , Hamidieh Amir Ali 
Published: April 2023

AbstractObjectivesFanconi anemia (FA) is a rare, heterogeneous, inherited disorder. Allogeneic hematopoietic stem cell transplantation (HSCT) represents the only therapeutic option to restore normal hematopoiesis. This study reports the outcomes of FA‐HSCT patients and identifies factors, including clinical phenotype. Our team examined more than 95% of Iranian FA patients during the last decade.Study DesignOne hundred and six FA patients (age range: 2–41) who underwent HSCT from March 2007 to February 2018 were enrolled. Clinical characteristics of genetic disease, pre‐HSCT findings, HSCT indication, and long‐term follow‐up evaluated and recorded. Data were analyzed using SPSS 19.0.ResultsThe mean follow‐up period for survivors was 36 months (range, 1–101). The 3‐year overall survival (OS) and disease‐free survival were 72.2% and 71.2%, respectively. The 3‐year OS rate for patients with limited and extensive malformations was 78.8% and 56.6%, respectively (p = 0.025). Acute graft versus host disease incidence was 60.52% for patients with limited malformations versus 70% for patients with extensive ones (p = 0.49). Chronic graft versus host disease incidence for these two groups was 9.21% and 10%, respectively (p = 0.91).ConclusionsOS was not associated with each of the malformations singly; however, it was lower in the extensive group. The younger age of patients at the HSCT time leads to a higher OS. The differences in FA patients' outcomes and the various genotypes were probably related. These data provide a powerful tool for further studies on genotype–phenotype association with HSCT results.
Unraveling the Antibacterial and Iron Chelating Activity ofN‐Oxide Hydroxy‐Phenazine natural Products and Synthetic Analogs againstStaphylococcus aureus
Authors: Alatawneh Nadeem , Meijler Michael M. 
Published: April 2023

AbstractPhenazines are redox‐active secondary metabolites produced by many microorganisms, especially by bacteria. These compounds are often produced at high cell densities in various niches.Pseudomonasstrains are the most common phenazine producers, and phenazine production in these bacteria is controlled by quorum sensing, a mechanism that enables bacteria to collectively respond to changes in cell density. As phenazines exhibit a wide range of activities against many different species, this has led to increased interest and studies related to their mechanisms of action. In this work, we have investigated and evaluated the activity of an array of phenazine‐based natural products and their analogs on Gram‐positive bacteria that share the same natural niches withPseudomonas, such as the human pathogenStaphylococcus aureus. This human pathogen plays a major role in lung infections and is often found in such infections together withP. aeruginosa. Among the screened compounds, hydroxyl‐containing phenazines with a 5,10‐dioxide scaffold were found to exhibit potent inhibitory effects on the growth ofS. aureus. The natural product iodinin (1,6‐dihydroxyphenazine 5,10‐dioxide, 6), which was chosen as a model for this class of compounds has been found to strongly chelate iron (II), thus we examined the potential role of iron starvation in suppressing the growth of this pathogen by these phenazines that are generally linked to reactive oxygen species formation mechanisms. Our results suggest that chelation of essential metals, leading to a lack of important nutrients could have a significant contribution to the antibacterial activity of these phenazines, alongside with ROS production, DNA damage and oxidative stress.
Using click reaction to covalently link heterogeneous gold nanorods into head‐to‐head one‐dimensional chains with an alternating sequence as plasmonic Fano resonators
Authors: Chen Chen , Lin Zhan‐Hong , Lin Fan‐Cheng , Huang Li‐De , Lin Chun‐Cheng , Huang Jer‐Shing 
Published: April 2023

AbstractWe present the deterministic linkage of short and long gold nanorods into one‐dimensional (1D) alternating nanorod chains in a head‐to‐head manner using click reactions. By precisely controlling the surface chemistry, we achieve orientation‐specific and robust covalent linkage between nanorods with high‐product yield. The optical response of the alternating nanorod chains exhibits Fano‐like resonances. This method enables the high‐throughput production of covalently linked plasmonic particle networks consisting of heterogeneous nanoparticles with specifically chosen spectral responses.
Design of a dual‐band power amplifier over an octave bandwidth employing dual‐band resonators
Authors: Liu Jinting , Liu Chong , Shao Zhuang , Shi Weimin 
Published: April 2023

AbstractIn this article, a compact dual‐band resonator is proposed for designing dual‐band power amplifiers (DBPAs). The proposed resonator has the characteristics of the band‐pass filters, suppressing the out‐of band signals. It is illustrated the proposed resonator has a simple circuit topology without sacrificing the performances of the DBPA. To verify the methodology, a high efficiency DBPA prototype operating at 1.72 and 3.48 GHz is fabricated and measured. The DBPA obtains a bandwidth of 100 and 50 MHz at the low and high frequency bands, respectively. The measurement results show that the DBPA delivers a saturation power of 43.1 and 40.8 dBm at 1.72 and 3.48 GHz, respectively. The measured drain efficiencies of the DBPA are 75.4% and 68.6% at 1.72 and 3.48 GHz, respectively. Meanwhile, when the DBPA is stimulated by a 20 MHz LTE signal with a peak to average power ratio (PAPR) of 7 dB, the measured adjacent channel leakage ratios are lower than −50 dBc at both 1.72 and 3.48 GHz after digital predistortion.
The roles and perspectives of an informatics pharmacist practicing in the Australian healthcare setting: a qualitative study
Authors: Ismail Nur Fazlini , Snoswell Centaine , Banks Vivien , Falconer Nazanin 
Published: April 2023

AbstractBackgroundThe implementation of digital healthcare systems in hospitals globally and in Australia has led to the introduction of the informatics pharmacist as a career in the healthcare system. However, informatics pharmacists are not yet part of routine clinical services in Australia, so their perspective and roles are not well understood.AimTo explore pharmacists' and other health professionals' perspectives of the roles of informatics pharmacists within interprofessional teams in Australian health care.MethodThis study used semi‐structured interviews with experts in pharmacy and/or informatics. They were recruited using convenience sampling and snowballing. The interviews were audio‐recorded and transcribed and analysed using inductive thematic techniques to identify major themes. Ethical approval was received from the local institutional Human Research Ethics Committee (Approval No: 2020000069).ResultsThe process of inductive thematic analysis was used to analyse the interview transcriptions of 11 participants. Six themes were identified: (1) a promising future for the informatics pharmacists, (2) education, (3) specific skills, (4) scope of informatics role, (5) impacts, and (6) barriers. Participants described the career of informatics pharmacists as an emerging specialty in today's healthcare systems. The roles of informatics pharmacists in Australian health care are described together with the skills and knowledge required for these roles.ConclusionA key role of informatics pharmacists is to facilitate the appropriate use of digital systems to prevent medication errors and improve patients' safety. While international experience has shown the potential scope for an informatics pharmacist, this research shows the use of informatics pharmacists in Australia is in its infancy.
Developing a unit dose approach to managing oral opioid liquids in an Australian hospital
Authors: Bint Lewis , Rawlins Matthew , Lawrence Ashleigh , Tam Ken , Jenkins Barry 
Published: April 2023

AbstractBackgroundLiquid opioids (controlled drugs) in multidose bottles (MDBs) are associated with measurement losses, overfill variance, gradual contamination, and potential theft. Western Australian state poisons regulations and policies require rigorous accountability and previous reports have highlighted shortcomings in historical arrangements.AimTo describe the process and outcomes of a transition to unit dose pod (UDP) formulations for oral liquid opioids at our institution.MethodA UDP of oral oxycodone liquid was developed in partnership with a third‐party compounder and piloted on a paediatric ward. Additional UDP opioid formulations were developed and gradually replaced MDBs across our institution. Reportable discrepancies and staff satisfaction were compared between MDBs and UDPs. This project was registered as a quality improvement project (GEKO 27758) and considered exempt from human research and ethics approval by the South Metropolitan Health Service Human Research Ethics Committee.ResultsBetween May 2017 and May 2018, 3062 UDPs were distributed with nil discrepancies, and 133 MDBs were distributed with 16 discrepancies (0% vs 12%). Most staff (92%) reported more efficient inventory counts and improved confidence in product integrity for UDPs. Staff administrative overhead required to manage reportable discrepancies from volume errors was essentially eliminated. Five UDP opioid formulations were implemented in 27 inpatient wards including methadone‐maintenance UDPs for inpatient use. By late 2020, UDPs were in use across 19 hospitals in Western Australia (WA), with annual use exceeding 33 000 units.ConclusionThe UDP simplifies the management of controlled drug liquids by eliminating discrepancies associated with MDBs inventory management and increasing staff confidence in product quality, leading to significant uptake across WA.
A novel antioxidant protein of non‐phycobiliprotein family derived from marine red alga Porphyra haitanensis
Authors: Chuang Pan , Tao Fengting , Qi Bo , Xiang Huan , Chen Shengjun , Yang Xianqing 
Published: April 2023

AbstractBACKGROUNDOxidation has been reported as the one of the deterioration reactions of proteins in aquatic products. Searching for new bioactive substances from marine algae has been one of the main areas in food science and additives.RESULTSIn this study, a novel protein from the red alga Porphyra haitanensis was determined after ammonium sulfate precipitation and gel filtration chromatography. It closely corresponded to the antioxidant activity and was identified as an uncharacterized protein with a molecular mass of 43 kDa, designated Ph43. Bioinformatic analysis revealed that Ph43 is a novel protein of non‐phycobiliprotein family with putative chordin domains and rich in α‐helical conformation. Recombinant protein (rPh43) was expressed in Escherichia coli as a Hig‐tagged protein using a pET‐22b vector system and purified by affinity high‐performance liquid chromatography. Spectroscopy analysis revealed that there were no structural differences between rPh43 and natural recovered Ph43. Moreover, rPh43 showed equal/higher antioxidant activity compared with Ph43. rPh43 has the potential for application as a natural antioxidant for food stabilization.CONCLUSIONOur results identified a novel antioxidant protein with molecular mass of 43 kDa derived from Porphyra haitanensis that belongs to the non‐phycobiliprotein family. © 2023 Society of Chemical Industry.
Vinegar production via spontaneous fermentation of different prickly pear fruit matrices: changes in chemical composition and biological activities
Authors: Hammouda Mouna Ben , Castro Remedios , Durán‐Guerrero Enrique , Attia Hamadi , Azabou Samia 
Published: April 2023

AbstractBACKGROUNDThis study focused on the valorization of prickly pear (PP) fruit (Opuntia ficus‐indica) into vinegar by spontaneous surface fermentation on different starting matrices (with/without the addition of sucrose and with/without PP peel in the raw material). Different parameters were monitored during the fermentation process in terms of their physicochemical and biological properties.RESULTSPhysicochemical and phytochemical analysis revealed significant differences depending on the starting matrix. An increase in total phenolic content (TPC) was observed for the majority of samples when transformed from PP juice into PP vinegar revealing the role of fermentation in enhancing the bioactive compounds content. Better antioxidant and antibacterial activity were detected for vinegar samples compared with the initial starting matrix. Using whole PP fruit resulted in better TPC and antioxidant activity; in contrast, sugar addition had no significant effect on any studied data. Analysis of variance, taking into account the four factors that were studied (matrix, variety, with/without peel, and with/without sugar), demonstrated that only the factor ‘presence or absence of the peel’ had a significant influence on the TPC values.CONCLUSIONThis study demonstrated that both whole PP fruit and PP juice could be used as new raw materials for vinegar production. © 2023 Society of Chemical Industry.