bluuebunny/crossref_metadata_2025_split huggingface dataset:
Outcomes of Intravitreal Aflibercept 8 mg in Eyes With Neovascular Age-Related Macular Degeneration Previously Treated With Faricimab
Authors: Momenaei Bita , Yonekawa Yoshihiro , Abril Paige , McCullough Rachel , Abbey Ashkan M. 
Published: January 2025

Background and Objective
To assess the efficacy of intravitreal aflibercept 8 mg in treating neovascular age-related macular degeneration (nAMD) in patients previously treated with faricimab.

Patients and Methods
A retrospective study was conducted on nAMD patients with suboptimal response to faricimab injections who were switched to intravitreal aflibercept 8 mg. Visual acuity (VA) and optical coherence tomography features were evaluated.

Results

The study included 135 eyes from 85 patients who received an average of 7.4 (4) faricimab injections with a mean interval of 53 days, which decreased to 48 days by the 5th aflibercept 8 mg injection (
P
= 0.056). Mean VA at the time of switch was 63.9 (14.4) letters and was 65 (13.5) letters after four aflibercept 8 mg injections (
P
= 0.726). Mean central foveal thickness (CFT) at switch was 325 (104) µm which decreased to 272 (65) after four aflibercept 8 mg injections (
P
< 0.001). The incidence of intraretinal fluid and subretinal hemorrhage increased from 31.3% and 8.1% at switch to 52.2% and 21.7% (
P
= 0.029 and 0.004), respectively.

Conclusions
Switching from faricimab to aflibercept 8 mg did not result in interval extension or VA improvement. CFT decreased, but intraretinal fluid and subretinal hemorrhage increased. Further studies are warranted.

[
Ophthalmic Surg Lasers Imaging Retina
2025;56:xx–xx.]
Brumaire, un coup d’État sans éclat ?
Authors: Moullier Igor 
Published: January 2025

L’article explore les événements des 18 et 19 brumaire et met en lumière leur préparation à travers le témoignage des acteurs impliqués. Le coup d’État de Brumaire apparaît comme prévisible et prévu par de nombreux acteurs. Si l’alliance de plusieurs groupes d’acteurs plaçant leurs espoirs en Bonaparte est évidemment essentiel, le succès du coup d’État résulte aussi de la maîtrise de détails matériels, de la procédure parlementaire à la mise en scène de la journée du 19 brumaire pour permettre l’ajustement du comportement des acteurs, et peut être analysé à travers la grille de lecture des crises politiques proposée par Michel Dobry et Ivan Ermakoff.
Dix objets qui ébranlèrent le monde. Russie, 1917-1921
Authors: Sumpf Alexandre 
Published: January 2025

Tout au long de l’année 1917, en Russie, les objets ont été utilisés par les révolutionnaires à la fois comme outils d’affirmation de leur statut et comme signe de ralliement. Ces objets parfois fragiles, comme le premier décret de l’histoire en langue ukrainienne, un dessin d’enfant ou une ampoule électrique, ou létaux, comme les armes brandies par les ouvriers dans les usines, ont mobilisé les sens – la vue avec le drapeau rouge, l’ouïe avec les chants révolutionnaires – et suscité des émotions. Ils ont participé de l’expérience politique accélérée des nouveaux citoyens, entre marketing politique (la casquette de Lénine), incarnation concrète du pouvoir démocratique (le bulletin de vote), et tous types de propagande – par le film (pour le vote), l’affiche, les parois décorées des trains d’agitation des Rouges ou la politique monumentale. La floraison des images et des supports a fait de la rue un objet façonné en commun, et a permis aux citoyens de prendre conscience de la mutation radicale de l’espace public.
L’invention du concept d’adultisation par Guy Avanzini : Néologisme, Déplacement et Méprise
Authors: Andrieu Bernard , Mougniotte Alain 
Published: January 2025

Guy Avanzini, avant de développer sa philosophie de l’éducabilité des adultes dans ses ouvrages des années 1990, avait fondé ce concept d’Adultisation sur une réflexion sur l’adolescence. Si nous n’avons trouvé la source de son invention dans les manuscrits de Guy Avanzini, la postérité du terme, qui aurait découvert le terme par les psychanalystes de l’adolescence en 1985 !, prouve que l’éducabilité est au centre de son anthropologie philosophique.
A ABORDAGEM DA EDUCAÇÃO SEXUAL NO ENSINO BÁSICO: UMA REVISÃO E RELATO DE EXPERIÊNCIA
Authors: Martins Isabela Peixoto , Barbosa Carmem Patrícia , Defani Marli Aparecida 
Published: January 2025

A educação sexual no âmbito escolar é imprescindível para formação integral do aluno, a partir da abordagem dos conceitos biológicos e científicos é possível promover discussões que englobam as vivências e a subjetividade de cada pessoa, observando a construção social da sexualidade ao longo da história. Dessa forma, este trabalho pretende analisar como é a abordagem do tema Educação Sexual no ensino básico através da revisão de artigos e da aplicação de uma atividade de metodologia ativa em uma escola. Trata-se de uma pesquisa bibliográfica de abordagem qualitativa. Como aporte teórico utilizamos as obras de Eliane Rose Maio (2018) Gênero e sexualidade: Interfaces educativas, Mary Neide Damico Figueiró (2020) Educação Sexual: retomando uma proposta, um desafio e Paulo Freire (1996) Pedagogia da autonomia: saberes necessários à prática educativa. Nesse sentido, para alcançar o objetivo proposto, foram analisadas as contribuições da educação sexual na formação biopsicossocial do estudante e o enfretamento da violência sexual e de gênero por meio dessa formação. As atividades foram desenvolvidas com os educandos dos anos finais do Ensino Fundamental e do Novo Ensino Médio matriculados na Rede Estadual de Educação, a respeito da anatomia do Sistemas Genitais Feminino e Masculino, Métodos contraceptivos e Infecções Sexualmente Transmissíveis (IST), utilizando as metodologias ativas. Relatamos no presente artigo as atividades desenvolvidas no Colégio Estadual Alberto J. Byington Junior, localizado na cidade de Maringá - PR.
O desmatamento na Amazônia e as chuvas irregulares no Sul do Brasil: um alerta a sociedade
Authors: Pinha Gisele Daiane , Scoarize Matheus Maximilian Ratz , Rasvailer Vinícius da Silva , Leandro Heitor Donegá Ferreira , Ribeiro Maria Eduarda Araújo , Batista Vandick da Silva , Souza Flávia Kelly Siqueira de , Benedito Evanilde 
Published: January 2025

A partir da exposição de materiais científicos em eventos abertos ao público, o projeto “Resiliência em sistemas socioambientais ribeirinhos na Amazônia” do Programa Amazônia+10, tem exitosamente feito a difusão de informações sobre a correlação entre a importância da conservação do bioma amazônico e os ecossistemas paranaenses. O projeto é desenvolvido em parceria entre docentes e discentes da Universidade Estadual de Maringá, da Universidade Federal do Amazonas, da Universidade Federal de Alagoas e do Instituto Nacional de Pesquisas da Amazônia e, em maio de 2024, participou da Exposição Feira Agropecuária, Industrial e Comercial de Maringá (Expoingá) com uma mostra de materiais sobre rios voadores e comunidades tradicionais ribeirinhas. Ao longo dos 10 dias de evento, cerca de 200 mil pessoas visitaram o pavilhão com a exposição do projeto. Durante as visitas, o público da feira pôde observar os materiais e tirar dúvidas com os discentes voluntários. Dentre as interações, uma pequena parcela do público apresentou conhecimentos prévios sobre os conceitos relacionados às comunidades, a maioria, nativa da macrorregião Norte. Além disso, a maioria do público interessado tinha idade acima dos 30 anos. Ações de divulgação científica como essa, quando realizadas durante grandes eventos, fornecem informações valiosas ao público visitante, que pode levar esse conhecimento para suas cidades, estimulando a criação de iniciativas semelhantes, ampliando o alcance de iniciativas de divulgação científica e ações de conservação ambiental.
An observational study to evaluate the utility of surgical plethysmographic index as a tool to predict postoperative pain in patients receiving oral calcium channel blocker therapy
Authors: Shenoy Sweekar K. , Handattu Krishna M. , Muhamed Shiyad 
Published: January 2025

Abstract

Background and Aims:
Surgical plethysmographic index (SPI) is a monitoring parameter used to predict postoperative pain. Our primary objective was to determine whether the value of SPI obtained 10 min before expected completion of surgery can be used as a reliable tool to predict postoperative pain in patients receiving oral calcium channel blocker (CCB) therapy for hypertension. Our secondary objective was to determine if SPI can be used as a tool to predict awakening of the patient from anesthesia.

Materials and Methods:
Seventy patients on CCB were enrolled. SPI values at 10 min before the anticipated end of the surgical procedure were recorded. The mean value of 10 readings was calculated and used as the SPI score for the patient. The time that anesthetic was cut off till the time of extubation was taken as the time of awakening. Numerical rating pain scale assessed the patient’s level of postoperative pain 15 min after extubation. Thirty-five patients not on CCB were studied similarly to serve as controls. Data obtained were analyzed using Statistical Package for the Social Sciences version 28 for Windows through the Department of Medical Statistics. P value less than 0.05 was considered significant.

Results:
In patients on CCB, based on the r value, a positive correlation was noted between the mean SPI and NRS values on scatterplot (P = 0.009). In patients not on CCB, a positive correlation was noted between mean SPI and NRS. In both groups, a negative correlation was noted between mean SPI and awakening time, which was not significant.

Conclusions:
In patients receiving oral CCB, SPI values obtained 10 min before expected completion of surgery can be a reliable tool to predict postoperative pain, but not to predict awakening from anesthesia.
Estimation of blood lactate and bicarbonate levels after stored blood transfusion to predict ICU admission in patients undergoing major head and neck surgeries: A prospective observational study
Authors: Dorathy N Sonia , Payal Yashwant S. , Talawar Praveen 
Published: January 2025

Abstract

Background and Aims:
Major head neck surgeries are often associated with major blood loss requiring blood transfusion. However, in spite of transfusion, patients usually suffer adverse postoperative outcomes. Biomarkers can help in identifying such events early. This observational study was conducted to compare blood lactate and bicarbonate levels as predictors of adverse postoperative outcomes.

Materials and Methods:
Forty-eight adult American Society of Anesthesiologists Physical Status I–III patients met the inclusion criteria. Intraoperative blood loss was managed with stored blood transfusion as per transfusion trigger. Blood lactate and bicarbonate levels were measured preoperatively (Tbas), at the immediate postoperative period (T0), and at 8 h (T8), 16 h (T16), and 24 h (T24) postoperatively. Outcomes such as need for intensive care unit (ICU) admission, length of ICU stay, intraoperative blood transfusion, re-exploration rate, and mortality were recorded.

Results:
Blood transfusions and ICU admissions were required in 19 (39.6%) and 24 (50%) patients, respectively. Lactate levels of patients requiring blood transfusion and admission to ICU rose significantly from their baseline (1.30 ± 0.41 mmol/l) to 2.80 ± 1.14 mmol/l at the immediate postoperative period, which fell to 2.06 ± 0.78 mmol/l at 24 h postoperatively, compared to other patients who did not require transfusion and ICU admission (P < 0.001). The bicarbonate value did not show any significant change from its baseline (22.68 ± 1.83 mEq/l) at all time points (P = 0.8). In addition, no significant difference was noted regarding ICU admissions (P = 0.659) or blood transfusions (P = 0.788).

Conclusions:
Following major head and neck surgeries, blood lactate level is a good predictor, but bicarbonate is a poor predictor of the need for blood transfusions and ICU admission. Intraoperative blood transfusion failed to prevent rise in blood lactate level, which is taken as a surrogate marker of tissue hypoxia.
Perioperative dental injury awareness among anesthesiologists
Authors: Mullick Parul , Kumar Ajay , Prakash Smita , Jain Shruti 
Published: January 2025

Abstract

Background and Aims:
Perioperative dental injury is a known yet preventable complication. We assessed the anesthesiologists’ awareness of the predisposing factors, preventive measures, and subsequent management of these injuries, should they occur.

Material and Methods:
A prospective cross-sectional survey was conducted on 385 anesthesiologists practicing in Delhi-NCR to assess their awareness on prevention and management of perioperative dental injuries. A questionnaire comprising 35 questions designed to determine preanesthetic practices, knowledge of dental injury predisposing factors, preventive measures, injury management, and documentation was filled and the collected data was analyzed.

Results:
Dental risk assessment was always or mostly performed by 93% anesthesiologists. Most anesthesiologists (93%) felt it would be more informative and clearer if preexisting dental condition is noted on a dental chart. Dental consultation was always advised by 14% anesthesiologists for patients with loose or diseased tooth. Limited mouth opening (71%), intubation (98%), and use of laryngoscope (96%) were found to be associated with dental injury. For dental injury prevention, 74% anesthesiologists padded teeth with gauze and 51% preferred to use a video laryngoscope. Knowledge regarding handling and management of avulsed tooth was lacking in most anesthesiologists. Postanesthesia dental status was documented always by only 11%. However, 71% always documented dental injury.

Conclusions:
Using dental chart in preanesthetic evaluation sheet improves documentation. Anesthesiologists need to be sensitized to the benefits of preanesthetic dental consultation for vulnerable teeth. They need awareness about correct handling and need of immediate reimplantation of avulsed tooth and documentation of postanesthesia dental status.
The efficacy and safety of continuous transmuscular quadratus lumborum block for postoperative analgesia after laparoscopic nephrectomy: A prospective randomized clinical trial
Authors: Kumari Kamlesh , Jain Nidhi , Rathod Darshana K. , Syal Rashmi , Meshram Tanvi , Sharma Ankur , Kaur Manbir , Singh Mahendra , Bhatia Pradeep 
Published: January 2025

Abstract

Background and Aims:
Analgesic efficacy and safety of continuous catheter technique in transmuscular quadratus lumborum block (QLB3) for laparoscopic nephrectomy has not been studied. This study was planned to evaluate the efficacy and safety of ultrasound (US)-guided continuous QLB3 for postoperative analgesia after laparoscopic nephrectomy.

Material and Methods:
In this randomized, open-label, single-centered trial, 64 patients belonging to the American Society of Anesthesiologists, physical status grade I and II, 18–65 years of age, scheduled for laparoscopic nephrectomy were included. Patients were randomized into the QLB group and the control group. After surgery, the QLB group received transmuscular QLB with a 0.4 mL/kg bolus of 0.25% ropivacaine and catheter insertion for continuous infusion of 0.25% ropivacaine at 0.1 mL/kg/h. Patients in both groups received fentanyl (0.5 μg/kg) as rescue analgesia by IV PCA pump.

Results:
The data of 30 patients in each group were analyzed. Total fentanyl consumption during the first 48 h postoperatively was significantly lower in the QLB group compared to the control group (mean ± SD; QLB group = 74.33 ± 32.75 μg; control group = 209.10 ± 52.04 μg) (P < 0.001). Postoperative NRS pain scores at rest and on movement were significantly lower in the QLB group compared to the control group at various time intervals up to 48 h postoperative (P < 0.05). No severe complications were seen in any of the patients.

Conclusions:
US-guided continuous catheter transmuscular QLB reduced postoperative opioid consumption by 64.45% and decreased NRS pain scores after laparoscopic nephrectomy without complications.
Comparison between dexmedetomidine and ketofol in the prevention of postoperative emergence delirium in pediatric patients undergoing orofacial cleft surgery: A randomized controlled trial
Authors: Surabhi  , Kumari Poonam , Kumar Amarjeet , Sinha Chandni , Kumar Ajeet , Singh Veena K. 
Published: January 2025

Abstract

Background and Aims:
Emergence delirium (ED) is a common postoperative complication in pediatric patients. To avoid postoperative ED, sedative medications have been utilized in addition to general anesthesia. In this study, the primary objective was to assess the incidence of postoperative emergence of delirium at 0-, 10-, 20-, 30-, and 60-min intervals. Secondary objective was to assess postoperative analgesia (0, 10, 20, 30, and 60 min) and hemodynamic parameters (mean arterial pressure, pulse, oxygen saturation).

Material and Methods:
In this randomized controlled study, 105 American Society of Anesthesiologists I and II patients, aged between 3 months and 2 years, scheduled for orofacial cleft surgery were enrolled. Patients of group I received dexmedetomidine (0.3 μg/kg), group II received ketofol (a mixture of ketamine 0.25 mg/kg and propofol 1.0 mg/kg), and group III received normal saline 10 min before extubation. The incidence of postoperative ED using the Watcha scale and the postoperative pain using the Face, Legs, Activity, Cry, Consolability (FLACC) scale were recorded.

Results:
The Watcha scale at the immediate postoperative period and at 10-, 20-, 30-, and 60-min intervals was 0 (1), 1 (1.75), 1 (1), 2 (2), and 3 (2) in group I, 1 (1), 2 (1), 2 (2), 2 (3), and 3 (2) in group II, and 2 (1), 3 (1), 3 (1.25), 4 (1), and 4.5 (1.5) in group III, respectively, at the above time points. On comparing group I with groups II and III, the difference was significant (P < 0.01). The FLACC score at the immediate postoperative period and at 10-, 20-, 30-, and 60-min intervals was 1 (1), 1 (1), 1 (1), 2 (2), and 3 (2) in group I, 2 (2), 2 (1), 2 (2), 2(3), and 3 (2) in group II, and 4 (1), 3 (1), 3 (1.25), 4 (1), and 4.5 (1.5) in group III, respectively, at the above time points. The FLACC score was also lower in group I in comparison to groups II and III. The difference among the groups was significant (P < 0.01). The incidence of postoperative delirium was lower in group I at 20% (7/35) than in group II at 29% (10/35) and in group III at 49% (17/35), and difference among the groups was significant (<0.01).

Conclusions:
We conclude that both dexmedetomidine and ketofol are effective in reducing postoperative ED. Dexmedetomidine is more effective than ketofol in preventing postoperative ED in the pediatric population.
THE INSTITUTIONAL FRAMEWORK OF MANAGEMENT CRISES AND DISASTERS IN HELLAS AND THE KNOW-HOW OF THE OLYMPIC GAMES 2004. THE CASE OF THE SELF-GOVERNMENTAL ORGANIZATIONS
Authors: Korontzis Tryfon 
Published: January 2025

<p>The purpose of the study (using the legal framework, bibliography and articles) is the legal-critical examination of the institutional framework that refers to the management of crises and disasters in Hellas (which has faced many unsuccessfully in the last 20 years) and how the crisis-disaster management know-how developed in Hellas in 2004 during the Olympic Games (OG) could help to improve this. In this context, the responsibilities of the Self-Governmental Organizations will be examined and analysed as how these contribute or could contribute more effectively to the prevention-management-counteraction of crises and disasters. The study will be completed by presenting conclusions and proposals.</p><p> </p><p><strong> Article visualizations:</strong></p><p><img src="/-counters-/soc/0762/a.php" alt="Hit counter" /></p>
Digital Didactic Competencies of Prospective Teachers in Arabian Countries
Authors: Awais Buthiana Elias , Daradkah Amjad Mahmoud , Haggag Haggag Mohamed , Hourieh Ali Hussein , Mahmoud Ashraf Mahmoud , Al-Ibrahim Adnan B. , Shahine Karima 
Published: January 2025

Objectives: This research aimed to identify the reality of digital didactic competencies of preserve teachers in different Arab teacher education systems in the Arabian context.

Method:The researchers followed the descriptive and analytical approach to identify the reality of preserve teachers’ mastery of digital didactic competencies. The research utilized a questionnaire that was validated and used for the purpose of the research; it consisted of five areas and 50 items. Participants of the research were 530 teachers from the Arabian educational contexts.

Results and Discussion: Results of the research showed that three areas of digital competencies were reported to be Mid (AI for lesson planning 1.68, AI for classroom management 1.77, and AI for assessment of learning 1.82). Results also showed that AI for Conducting a Lesson (2.80) was reported to be High, while AI for Methodology (1.29) was reported to be low. Based on the obtained results, the study recommends integrating various digital competencies-oriented models in pre-service teacher education programs in the Arabian context.

Research Implications: Extensive decisions related to curriculum reform and syllabus-oriented practices are recommended to fulfill the indulgence of pedagogical digital literacies in the Arabian educational contexts.

Originality/Value: The study highlighted the need to integrate further pedagogical digital competencies components in pre-service teacher education programs due to the age requirements. Teacher education institutes in the Arab world place a greater emphasis on " digital pedagogy" than they did on imparting specific knowledge that students would eventually be expected to apply.