bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy of modified posterior shoulder stretching exercises on shoulder function in subacromial impingement syndrome: A comprehensive meta-analysis
Authors: Guo Rui , Luo Yujun , Xu Yang , Lan Kang , Zhao Yan 
Published: January 2025

Background:
Subacromial impingement syndrome (SIS) is a common cause of shoulder pain and dysfunction. Modified posterior shoulder stretching exercises have been proposed as a treatment method aimed at improving shoulder function and reducing pain in patients with SIS. However, the efficacy of these exercises remains controversial, necessitating a systematic meta-analysis to comprehensively evaluate their effectiveness.

Methods:
A systematic search was conducted across PubMed, Cochrane Library, Embase, and Web of Science databases to identify randomized controlled trials (RCTs) and observational studies evaluating the efficacy of modified posterior shoulder stretching exercises in patients with SIS. Inclusion criteria required that participants be diagnosed with SIS, the intervention be modified posterior shoulder stretching exercises, and key outcomes such as shoulder function improvement and pain relief be reported. Meta-analysis was performed using RevMan 5.3 software, calculating standardized mean differences (SMD) with 95% confidence intervals (CI), and heterogeneity and bias risk were assessed.

Results:
A total of 10 RCTs with 628 patients were included. The modified posterior shoulder stretching exercises demonstrated significant effects in reducing pain at rest (SMD = –1.00, 95% CI: −1.85 to −0.15, P = .02) and during activity (SMD = –1.45, 95% CI: −2.49 to −0.41, P = .006). Additionally, the exercises showed positive effects in improving internal rotation (SMD = 0.49, 95% CI: 0.22–0.75, P = .0003) and external rotation range of motion (SMD = 0.29, 95% CI: 0.00–0.58, P = .05), as well as enhancing shoulder function (CMS score: SMD = 0.95, 95% CI: 0.64–1.25, P < .00001) and reducing disability (quick DASH score: SMD = –0.85, 95% CI: −1.12 to −0.58, P < .00001). Sensitivity analysis indicated high robustness of the results, and Egger test did not reveal significant publication bias (P > .05).

Conclusion:
Modified posterior shoulder stretching exercises are significantly effective in improving shoulder function and reducing pain in patients with SIS, with the study results showing high robustness and low risk of bias. However, further high-quality research is needed to validate these findings.
Comparative analysis of general and regional anesthesia applications in geriatric hip fracture surgery
Authors: Li Ping , Li Xi , Peng Guiying , Deng Jun , Li Qiang 
Published: January 2025

Background:
This study compares the outcomes of general anesthesia (GA) and regional anesthesia (RA) in geriatric hip fracture surgery to determine optimal anesthesia strategies for this population.

Methods:
A comprehensive literature review was conducted, analyzing studies comparing GA and RA in elderly patients undergoing hip fracture surgery. Studies encompassed various designs, including randomized controlled trials, cohort studies, and meta-analyses. Key analytical techniques included comparative analysis of intraoperative complications, postoperative outcomes, mortality rates, and physiological impacts.

Results:
GA was associated with higher risks of intraoperative cardiovascular events, respiratory depression, and postoperative complications such as cognitive dysfunction and delirium. In contrast, RA demonstrated superior outcomes in pain management, early mobilization, and reduced incidences of complications like postoperative nausea and vomiting. RA also correlated with shorter hospital stays and lower mortality rates within the first 30 days post-surgery.

Conclusion:
RA emerges as a preferable choice for geriatric hip fracture surgery, offering improved safety profiles, enhanced recovery trajectories, and better postoperative cognitive outcomes compared to GA. These findings underscore the importance of anesthesia selection in optimizing surgical outcomes and patient safety in elderly populations. Future research should focus on prospective trials to validate these results and refine anesthesia protocols tailored to elderly hip fracture patients.
Laparoscopic peritoneal mucinous cystadenoma debulking: A case report
Authors: Guo Zhitang , Long Kui , Chen Zhanbin , Zhang Wei , Chu Quanxian 
Published: January 2025

Rationale:
Peritoneal mucinous cystadenoma is rare in the clinic, lacks specific clinical manifestations, tumor markers, and imaging features, and is easily misdiagnosed and missed. Clinical practitioners should maintain a high level of vigilance. Here, we report a case of laparoscopic peritoneal mucinous cystadenoma stripping to improve our understanding of the disease.

Patient concerns:
A 34-year-old woman was admitted to our hospital with a history of epigastric pain over the past year that had worsened over the previous 4 months. The patient had no history of trauma or surgery.

Diagnoses:
A computed tomography scan of the whole abdomen, as well as hepatobiliary and pancreatic scans and magnetic resonance cholangiopancreatography examinations, showed a low-density mass of approximately 5.8 × 4.8 cm between the right lobe of the liver and the right kidney. The lesion showed no significant enhancement on the enhanced scan, and analysis of tumor markers was normal. The preoperative diagnosis was cholelithiasis with cholecystitis and hepatic cysts.

Interventions:
It was proposed to perform “laparoscopic cholecystectomy + hepatic cyst decapitation and decompression” under general anesthesia; however, intraoperative exploration revealed that the abdominal cyst had originated from the right side of the peritoneum and was located between the liver and kidney. The surgical procedure was thus changed to “laparoscopic abdominal cyst removal + cholecystectomy.”

Outcomes:
The patient recovered well and was discharged on the fourth postoperative day. Postoperative pathological examination (abdominal cyst) showed mostly serous cells partially covered with high columnar mucus cells, which was consistent with mucinous cystadenoma. The postoperative diagnosis was peritoneal mucinous cystadenoma and cholecystolithiasis with cholecystitis.

Lessons:
Clinical diagnosis of mucinous cystadenoma of the abdominal wall is difficult. The possibility of the disease should be considered when a cystic space is found in the abdominal cavity. Diagnosis depends on postoperative pathological examination, and surgery is the preferred treatment option. During the operation, attention should be paid to avoid rupture of the cyst wall and overflow of cyst fluid, and to avoid blind fenestration and drainage or puncture and aspiration sclerotherapy when the diagnosis is unclear.
Bushen-Huoxue-Mingmu-Formula attenuates pressurization-induced retinal ganglion cell damage by reducing mitochondrial autophagy through the inhibition of the Pink1/Parkin pathway
Authors: Wang Wei , Gao Jia , Mu Qianqian , Zhang Dan , Yang Fen , Cheng Wubo 
Published: January 2025

Background:
Bushen-Huoxue-Mingmu-Formula (MMF) has achieved definite clinical efficacy. However, its mechanism is still unclear.

Objective:
Investigating the molecular mechanism of MMF to protect retinal ganglion cells (RGCs).

Methods:
This study developed a pressurization-induced model of damaged RGCs, which were then treated with a serum supplemented with MMF. The effects of MMF on proliferation, apoptosis, adenosine 5′-triphosphate content, and mitochondrial structure of RGCs were investigated, and the underlying molecular mechanism was explored by RNA interference experiment.

Results:
In the pressurization-induced RGC injury model, apoptosis rate increased, cell proliferation decreased, adenosine 5′-triphosphate content reduced, mitochondrial structure was disrupted, BCL2-associated X, cleaved caspase-3, and microtubule-associated proteins light chain 3 II/I protein expression enhanced, B cell lymphoma-2 and p62 protein expression decreased, and the Pink1/Parkin pathway was activated. The stress-induced damage to RGCs was, however, reversible following MMF-mediated inhibition of the Pink1/Parkin pathway. Pink1 short-hairpin RNA downregulated Pink1 expression in RGCs, which led to outcomes that aligned with those observed with MMF intervention.

Conclusions:
MMF altered the expression of apoptosis- and autophagy-related proteins and possibly inhibited the Pink1/Parkin signaling pathway, which led to reduced pressurization-induced mitochondrial autophagy in RGCs. This preventive effect of MMF on RGCs can be potentially useful to preserve the viability of RGCs.
Cholesterol-Dependent Dimerization and Conformational Dynamics of EphA2 Receptors: Insights from Coarse-Grained and All-Atom Simulations
Authors: Sahoo Amita R. , Bhattarai Nisha , Buck Matthias 
Published: January 2025

AbstractThe EphA2 transmembrane receptor is a key regulator of cellular growth, differentiation, and motility, and its overexpression in various cancers positions it as a promising biomarker for clinical cancer management. EphA2 signaling is mediated through ligand-induced dimerization, which stabilizes its dimeric state via conformational changes in the extracellular region and is linked to the intracellular kinase region via the transmembrane (TM) domain. Similar to many receptor tyrosine kinases, the juxtamembrane (JM) region, located between the TM and catalytic domains, coordinates with the TM domain to facilitate signal transduction. Electrostatic interactions between basic residues of the JM region and signaling lipids, such as PIP2 and PIP3, play a critical role by sequestration thereby inhibiting phosphorylation of the JM and other intracellular tyrosines. Cholesterol’s potential role in allosterically modulating EphA2 activation has remained unclear. Therefore, elucidating the structural mechanism of EphA2 dimerization and its membrane interactions is essential for understanding the influence of these lipids. In this study, we modeled the TM-full JM peptide of the EphA2 receptor and employed both coarse-grain (CG) and all-atom (AA) simulations to investigate the conformational transitions of the EphA2 transmembrane region dimer in cholesterol-rich and cholesterol-deficient membranes. Our study reveals that cholesterol stabilizes specific EphA2 TM dimers and TM-JM PIP2 interactions, highlighting the critical role of membrane composition in regulating EphA2 dimerization, oligomerization, and clustering.
Exploring the Impact of Aphasia Severity on Employment, Social Participation, and Quality of Life
Authors: Konishi Mika , Funayama Michitaka , Saito Fumie , Nakagawa Yoshitaka , Fujinaga Naomi , Urano Masayo , Osumi Masanori , Harayama Shu , Tateishi Masako , Tanemura Jun , Mimura Masaru 
Published: January 2025

AbstractBackgroundThe primary challenge faced by patients with aphasia is their difficulties in communicating, which likely contributes to lower employment rates, decreased social participation, and a decline in quality of life. Surprisingly, few studies have investigated the relationship between aphasia severity and these outcomes, particularly employment status. In this study, we addressed this gap by examining these socio-occupational outcomes as well as quality of life in individuals with chronic aphasia.MethodsA cohort of 136 individuals with chronic aphasia following cerebrovascular diseases was recruited and investigated in a cross-sectional study. A multiple logistic regression model was used for employment status, and multiple linear regression models were used for both social participation levels and quality of life. Explanatory variables included both individual’s functions, such as aphasia severity, non-linguistic cognitive function, apathy levels, and mobility, as well as levels of social environmental barriers.ResultsAphasia severity had a significant negative impact on two outcomes: employment status and quality of life. Additionally, social environmental barriers negatively affected quality of life. Lower mobility, male gender, and older age were related to reduced social participation levels. Employment status was not related to social participation levels nor quality of life.ConclusionThis study found that the severity of aphasia significantly impacts individuals’ occupational engagement, as well as their quality of life. Our findings shed light on potential treatment options during acute phases of stroke, linguistic rehabilitation, and occupational support for individuals with aphasia.
Initial Estimates of the Minimal Clinically Important Difference (MCID) for the Neuropathic Pain Symptom Inventory (NPSI): A Systematic Meta-Analysis
Authors: Canori Alexandra , Howard Rebecca , Bower Jeffrey , Putrino David , Tabacof Laura 
Published: January 2025

AbstractObjectiveThe Neuropathic Pain Symptom Inventory (NPSI) is commonly used assessment in Neuropathic Pain (NP) trials, yet a Minimal Clinically Important Difference (MCID) has not been established. A MCID would enhance the interpretability of NPSI scores, guiding clinicians and researchers in assessing clinically important improvements in NP symptoms. The aim of this study was to calculate an MCID from the available scientific research that used the NPSI.MethodsWe conducted a systematic review and meta-analysis of NP trials reporting the NPSI. Three distributional approaches were applied to estimate the MCID: pooled standard deviation (SD) of change scores, pooled baseline SD, and a random-effects meta-analytic approach. Only treatments arms within RTCs were examined. Treatment arms were grouped by NP etiology, enabling etiology-specific MCID estimates. Bias for each included study was assessed using the Cochrane tool for quality assessment of randomized controlled trials.Results323 trials were examined, 12 were selected for inclusion for a total of 17 treatment arms. The calculated MCID estimates for the NPSI total score were 7.95 using pooled SD of change scores, 7.73 using pooled baseline SD, and 6.85 using the random-effects method. Etiology-specific MCIDs varied, with Post-Infectious conditions and Diabetic Peripheral Neuropathy showing higher values than other NP types.ConclusionThis study provides preliminary MCID estimates for the NPSI. Limitations include limited data for certain NP subtypes, highlighting the need for additional anchor-based and etiology-specific MCID research to refine these estimates. These findings can aid in future NP trial design and the interpretation of results.
High-Frequency vs. Low-Frequency Music Therapy in Psychiatric Inpatients: A Randomized Controlled Trial
Authors: Esteban-Cárdenas Manuel , Gómez-Puentes Ana , Torres-Delgado Carlos , Hidalgo-Valbuena Adrián , Ferro Eugenio 
Published: January 2025

AbstractIntroductionMusic therapy is an evidence-based clinical intervention with demonstrated efficacy in reducing anxiety and depression and in neuromodulation that promotes well-being. Sessions are usually delivered weekly. Psychiatric hospital stays are progressively shorter, requiring interventions to be delivered in brief intensive schemes. Our objective was to evaluate the effectiveness of a high-frequency intervention music therapy (5 sessions/week) compared to a low-frequency (1 session/week) control group.Materials and methodsThis is a randomized controlled clinical trial in patients with mental disorders under in-hospital psychiatric treatment. A computer-based random generator created a random allocation sequence to guarantee equal group assignment probability. The primary outcome was symptoms in the Depression/Anxiety/Stress Scale of 21 items (DAS-21). Secondary outcomes were the impact of music therapy sessions on adult patients measured with the CISMA questionnaire (CISMA by Spanish acronyms), and global life satisfaction with the single item for measuring overall life satisfaction (SWLS). To mitigate risks associated with the interventions, at least one healthcare professional will attend each session, alongside a certified music therapist.The Shapiro-Wilk test was used to test the distribution of variables. We used the Mann-Whitney U test to prove differences between groups and the Wilcoxon signed-rank test differences within groups. Spearman’s test was performed to determine the correlation between continuous variables. Statistical analysis was performed with Jamovi (version 2.6, 2024).ResultsPatients in the intervention group had a significant stress level reduction compared to the control group (p=0.033). Both groups experienced significant improvements in anxiety, depression, and global life satisfaction. In addition, positive expectations towards music therapy were associated with greater symptom reduction (r=-0.33, p=0.004).DiscussionTo the best of our knowledge, this study is the first randomized controlled trial comparing high-frequency and low-frequency music therapy for psychiatric inpatients. Although both groups demonstrated significant improvement in all the outcomes measured, only the high-frequency group demonstrated greater benefit for stress symptoms. Changes in physiological stress have been reported previously, concordant with our psychological findings. Music therapy had a probable suggestive effect on symptom reduction. These findings highlight the potential of music therapy for stress management in psychiatric hospitals but emphasize the need for further research to standardize session intensity and treatment duration.Trial Registration:ISRCTN registry:ISRCTN87861817(https://www.isrctn.com/ISRCTN87861817)
Impaired oxidative phosphorylation drives primary tumor escape and metastasis
Authors: Arner Emily N. , Jennings Erin Q. , Crooks Daniel R. , Ricketts Christopher J. , Wolf Melissa M. , Cottam Matthew A. , Fisher-Gupta Emilie L. , Lang Martin , Maio Nunziata , Shibata Yuki , Krystofiak Evan S. , Vlach Logan M. , Hatem Zaid , Blatt Alexander M. , Heintzman Darren R. , Sewell Allison E. , Hathaway Emma S. , Steiner KayLee K. , Ye Xiang , Schaefer Samuel , Bacigalupa Zachary A. , Linehan W. Marston , Beckermann Kathryn E. , Mason Frank M. , Idrees Kamran , Rathmell W. Kimryn , Rathmell Jeffrey C. 
Published: January 2025

SummaryMetastasis causes most cancer deaths and reflects transitions from primary tumor escape to seeding and growth at metastatic sites. Epithelial-to-mesenchymal transition (EMT) is important early in metastasis to enable cancer cells to detach from neighboring cells, become migratory, and escape the primary tumor. While different phases of metastasis expose cells to variable nutrient environments and demands, the metabolic requirements and plasticity of each step are uncertain. Here we show that EMT and primary tumor escape are stimulated by disrupted oxidative metabolism. Using Renal Cell Carcinoma (RCC) patient samples, we identified the mitochondrial electron transport inhibitor NDUFA4L2 as upregulated in cells undergoing EMT. Deletion of NDUFA4L2 enhanced oxidative metabolism and prevented EMT and metastasis while NDUFA4L2 overexpression enhanced these processes. Mechanistically, NDUFA4L2 suppressed oxidative phosphorylation and caused citric acid cycle intermediates to accumulate, which modified chromatin accessibility of EMT-related loci to drive primary tumor escape. The effect of impaired mitochondrial metabolism to drive EMT appeared general, as renal cell carcinoma patient tumors driven by fumarate hydratase mutations with disrupted oxidative phosphorylation were highly metastatic and also had robust EMT. These findings highlight the importance of dynamic shifts in metabolism for cell migration and metastasis, with mitochondrial impairment driving early phases of this process. Understanding mitochondrial dynamics may have important implications in both basic and translational efforts to prevent cancer deaths.
Addressing the Slippery Slope Argument: Trends in Euthanasia Among Patients with Psychiatric Disorders and Dementia in Belgium, 2002–2023
Authors: Wels Jacques , Hamarat Natasia 
Published: January 2025

AbstractBackgroundAssisted suicide of patients with psychiatric disorders or dementia have increased in countries like Belgium, the Netherlands, and Canada and are often mentioned to argue against euthanasia regulations, suggesting they lead to a slippery slope. We examine changes in euthanasia cases for patients with these conditions in Belgium.Data and methosWe use data on all cases of euthanasia reported to the Federal Commission for the Control and Evaluation of Euthanasia (FCCEE) from 2002 to 2023. Psychiatric disorders (N=427) and dementia (N=310) represent 1.27% and 0.92% of all cases, respectively. Using time-series Poisson regression, we model trends by first examining interactions between euthanasia reasons and year, then extending to three-way interactions with gender and region. We replicate the analyses with an offset to account for demographic changes.ResultsEuthanasia for psychiatric disorders and dementia showed distinct trends over time. Euthanasia for psychiatric disorders followed trends similar to the other types of euthanasia, while euthanasia for dementia showed a slight over-increase. Demographic change explains part of the increase in euthanasia for dementia and other reasons but not psychiatric disorders. While euthanasia rates for psychiatric disorders were initially higher for women, the trend for men is catching up over time. Regional trends indicate higher overall euthanasia rates in the Dutch-speaking population but with faster increases in the French-speaking population.DiscussionThe Belgian experience demonstrates that assisted dying laws can include non-terminal psychiatric conditions with appropriate safeguards and without evidence of significant misuse, addressing concerns about the slippery slope argument.
Direct evidence of alteration to the human neural intracellular trafficking system following exposure to HSV: A systematic review
Authors: Vaughan Michael B. , Bellai Dante J. , Rae Mark G. 
Published: January 2025

AbstractThere is a growing interest in the potential role that lifelong chronic viral infections may play in the aetiology of certain neurodegenerative diseases. For example, the disruption of neuronal intracellular trafficking by repeated reactivations of latent herpes viruses has been proposed as a possible inductive agent of Alzheimer’s disease (AD). This systematic review examines the extent of primary data that have examined the effect(s) of herpes viruses on the human intraneuronal trafficking (HINT) system. Three databases (MEDLINE, SCOPUS, and Web of Science), were repeatedly searched. 5782 articles were identified, of which 13 met our eligibility criteria, and five were included for qualitative synthesis. Four of the five collated studies presented data from cell culture experiments, wherein herpes simplex virus 1 (HSV-1) altered lysosomal load, lysosomal function, and activity-regulated cytoskeleton-associated protein (ARC) mRNA/protein expression in a cell-type/species specific manner. One of the five studies was a clinical case study that presented observations on a fatal herpes encephalopathy, wherein the neuronal endoplasmic reticulum and Golgi apparatus were ablated by the rampant infection. Unfortunately, there is an extremely limited amount of primary research examining the effects of herpes viruses on the HINT system, but within that limited pool there is clear evidence of cell type-/stage- specific responses to infection. Future studies investigating herpes infection in neurodegenerative disease need to utilise cell-type and species- specific models if they are to have any hope of extrapolating to a clinical setting.