bluuebunny/crossref_metadata_2025_split huggingface dataset:
Incorporation of peer‐feedback into the pedagogical use of spherical video‐based virtual reality in writing education
Authors: Chen Yu‐Ting , Li Ming , Cukurova Mutlu , Jong Morris Siu‐Yung 
Published: August 2023

Writing is a fundamental skill linked closely with academic achievement, day‐to‐day communication, formal negotiations, and more. However, due to their lack of contextual experience, learning to write has been a demanding and complex cognitive process for most learners. As a result, learners struggle to exhibit positive learning behaviours and cognitive engagement in writing, let alone embrace deep and autonomous learning. To solve these problems, in the present study, a spherical video‐based virtual reality (SVVR) learning environment is developed to provide students with a contextual learning experience. Moreover, a peer feedback strategy is used to guide students in deep learning in writing. A quasi‐experimental study was conducted to verify the effectiveness of the proposed approach. A total of 79 students from one primary school in southeast China were recruited. The students were assigned to either the experimental group (EG) exposed to the peer‐feedback‐based SVVR (PF‐SVVR) approach or the control group (CG) exposed to the conventional SVVR (C‐SVVR) approach. The results show that PF‐SVVR had more positive effects than C‐SVVR in terms of students' writing performance, cognitive engagement and autonomous learning tendency. In addition, the PF‐SVVR approach was found to be more beneficial for triggering deep learning in writing than the C‐SVVR approach. This study further found that students in the PF‐SVVR group tended to exhibit less disorderly behaviours than those in the C‐SVVR group. Our study contributes to the prior literature by exploring the educational potential of the PF approach in the context of SVVR‐enabled writing learning.
Practitioner notesWhat is already known about this topic

Peer feedback approach provides opportunities for writing learners to regulate their longer‐term cognitive and behavioural competencies.
Spherical video‐based virtual reality (SVVR) not only provides an authentic experiential learning context for learners, but it also significantly reduces the cost and the need for the high‐tech capabilities of traditional VR.
What this paper adds

A peer feedback‐based SVVR approach is proposed to promote students in learning to write.
It was found that students' quality of learning to write can be improved by applying the PF‐SVVR approach in writing courses.
Implications for practice and/or policy

It is worth promoting the application of the peer feedback strategy and SVVR in school settings.
The PF‐SVVR approach is useful for promoting young writing learners' cognitive engagement, autonomous learning tendency and deep learning.
Further investigations on the effects of employing the PF‐SVVR approach in writing, with anonymous strategies in the process of giving or receiving peer feedback, are expected.
Clinical effect of Nobel Biocare angulated screw channel crown compared with cement crown in the aesthetic area: A retrospective cohort study with a mean 32 months follow‐up (range 12 to 70 months)
Authors: Yang Hang , Xu Lehan , Jiang Jimin , Xu Yuzi , Li Xiaojun , He Fuming 
Published: August 2023

AbstractObjectiveThe objective of this study is to compare the clinical efficacy of angulated screw channel abutment applied in the anterior area with regular cemented crowns.Materials and MethodsForty‐eight patients were included and divided into two groups: the angulated screw channel group (ASC) and regular cemented group (RC) in this retrospective cohort study. The evaluation criteria included implant/restoration survival rate, keratinized mucosa width (KMW), bleeding on probing rate (BOP%), probing depth (PD), pink aesthetic score (PES), mechanical/biological complications, emergence angle (EA), the site of implant axis penetrate (SA), marginal bone loss (MBL), and buccal bone thickness (BBT) at 0 mm, 1 mm, 3 mm, 5 mm below the implant shoulder were evaluated in immediate postoperative (T0) and follow‐up period (T1).ResultsThis retrospective cohort study included a total of 48 patients, with a mean 32 months follow‐up period range from 12 months to 70 months. The study did not find any cases of implant failure or restoration failure. EA was significantly wider in the RC group than ASC group (RC: 33.53° ± 8.36° vs ASC: 27.43° ± 8.08°, p = 0.016*). While the BOP% was statistically significant higher in the RC group than ASC group (RC: 28.35% ± 22.92% vs ASC: 13.18% ± 20.00%, p = 0.027*). No significant differences were observed in the other measurements of comparison.ConclusionWithin the limitations of the study, angulated screw channel (Nobel Biocare) crowns might allow the implant axis aim at incisal edge to reduce the emergence angle in the anterior area and benefit the soft‐tissue during the 12–70 months follow‐up period.
The value of FDG combined with PiB PET in the diagnosis of patients with cognitive impairment in a memory clinic
Authors: Liu Fang , Shi Yudi , Wu Qiuyan , Chen Huifeng , Wang Ying , Cai Li , Zhang Nan 
Published: August 2023

AbstractAimsTo analyze the value of 18F‐fluorodeoxyglucose (FDG) positron emission tomography (PET) combined with amyloid PET in cognitive impairment diagnosis.MethodsA total of 187 patients with dementia or mild cognitive impairment (MCI) who underwent 11C‐Pittsburgh compound B (PiB) and FDG PET scans in a memory clinic were included in the final analysis.ResultsAmyloid‐positive and amyloid‐negative dementia patient groups showed a significant difference in the proportion of individuals presenting temporoparietal cortex (p < 0.001) and posterior cingulate/precuneus cortex (p < 0.001) hypometabolism. The sensitivity and specificity of this hypometabolic pattern for identifying amyloid pathology were 72.61% and 77.97%, respectively, in patients clinically diagnosed with AD and 60.87% and 76.19%, respectively, in patients with MCI. The initial diagnosis was changed in 32.17% of patients with dementia after considering both PiB and FDG results. There was a significant difference in both the proportion of patients showing the hypometabolic pattern and PiB positivity between dementia conversion patients and patients with a stable diagnosis of MCI (p < 0.05).ConclusionTemporoparietal and posterior cingulate/precuneus cortex hypometabolism on FDG PET suggested amyloid pathology in patients with cognitive impairment and is helpful in diagnostic decision‐making and predicting AD dementia conversion from MCI, particularly when combined with amyloid PET.
Attitudes to pangolins and factors affecting their conservation in a human dominated landscape in Nepal
Authors: Suwal Tulshi Laxmi , Gurung Sabita , Johnson Paul J. , Shrestha Manoj Bakhunchhe , Parker Keri , Pei Kurtis Jai‐Chyi 
Published: August 2023

AbstractPangolins in Nepal are found mostly in human‐dominated landscapes where their numbers are declining due to illegal hunting and trade. Positive attitudes of local people are believed to be powerful drivers for the conservation of threatened species. We explored local attitudes using a semi‐structured questionnaire survey of 1017 people from 105 villages in rural areas across Nepal to investigate the key factors influencing local attitudes towards pangolins and their conservation. Topography and education level were identified as strong predictors of attitude scores as was geographic variation associated with differences between provinces. Positive attitudes were observed in the majority of respondents from Madhesh Province and Koshi Province in eastern Nepal, in those with higher levels of education and those from the lowland Terai region. Respondents from Karnali Province, western Nepal and those living in the Mid‐hill region, had significantly lower attitude scores. However, a significant number of respondents with negative attitudes towards pangolins in Karnali Province also reported higher levels of illegal hunting. Local stewardship can be promoted through awareness campaigns and alternative livelihood initiatives. Collaboration with local communities and stakeholders as well as their capacity enhancement should be a priority for the sustainable conservation of the species.
Patronage, tournament, and political reward: Evidence from the model county party secretary in China
Authors: Wei Wenchi , Xu Wen , Li Wenzhao 
Published: August 2023

AbstractThis study focuses on the honor of Model County Party Secretary, a prestigious award bestowed by the Communist Party of China to recognize exceptional county party secretaries. Specifically, we investigate how county party secretaries' patronage networks with senior politicians and their relative economic performance compared to other political contestants can impact their likelihood of winning this honor. We collect demographic and biographic data on a sample of over 2000 county party secretaries from various official documents and online sources. Instrumental variable estimations show that, in line with tournament theory, an increase in county party secretaries' relative economic performance enhances their likelihood of receiving the honor. However, county leaders' patronage networks with senior politicians negatively moderate the estimated impact of economic performance. This finding contradicts the inference drawn from patronage theory but supports the conjecture that senior politicians may exploit patronage networks to politically suppress subordinate leaders and prevent political uncertainty.
Plant‐based protein as an alternative to animal proteins: A review of sources, extraction methods and applications
Authors: Thakur Sheetal , Pandey Arun Kumar , Verma Kiran , Shrivastava Arpit , Singh Narpinder 
Published: August 2023

SummaryA major part of protein in human diet comes from the animal‐based foods such as meat and dairy products. The demand on protein‐rich food in global market is progressively escalating due to increasing consumer awareness about constructive role of protein in human well‐being. The changing scenario will ultimately promote the farming of meat and dairy animals to meet the increasing demand. However, the increase in livestock farming will lead to excessive environmental stress as it contributes to greenhouse gases emission, and negatively affecting the biodiversity. With an increase in awareness about environmental pollution, animal cruelty and negative impact of animal‐based food products on health, consumers are shifting towards plant‐based vegan substitutes. Apart from being a good protein source, plant‐based alternatives are also enriched with numerous other bioactive compounds, that is, polyphenols, antioxidants, vitamins and dietary fibres. The protein content of plant‐based sources, that is, cereals (6%–15%), legumes (20%–38%), pseudocereals (11%–23%), nuts (18%–38%) and seeds (9%–30%) is comparatively higher than milk (3%–5%), whereas approximately similar to meat (23%). Therefore, the current review is focused on assessment of major plant‐based protein sources that can be used for the development of protein‐rich food products as well as the animal food alternatives. The study also discusses about plant protein extraction techniques and development of animal‐based meat and dairy analogues using plant protein.
Plasma levels and urinary excretion of protein Z in patients with urolithiasis
Authors: Kaneko Kiyoko , Yasuda Makoto , Fukuuchi Tomoko , Yamaoka Noriko , Takahashi Kei , Mawatari Ken‐ichi , Isotani Shuji , Horie Shigeo , Nakagawa Tohru 
Published: August 2023

ObjectivesProtein Z (PZ) is a γ‐carboxyglutamic acid protein present in plasma that is involved in blood coagulation. Detailed analysis of urinary stones from patients with urolithiasis has revealed that PZ is often found in urinary stones composed of calcium oxalate monohydrate. In this study, we compared blood and urinary PZ concentrations between healthy individuals and patients with urolithiasis.MethodsPlasma and urine were collected from healthy individuals and patients with urolithiasis who provided informed consent. PZ was detected as a urinary stone matrix protein in some of the patients. PZ was quantified by ELISA, creatinine was measured by the enzymatic method, and the total protein concentration was measured by the Bradford method.ResultsThe plasma PZ level was 2.54 ± 1.02 μg/mL in healthy individuals and that in urolithiasis patients classified by stone history were from 1.16 ± 0.77 to 3.73 ± 1.09 μg/mL, which was not significantly different. The urinary excretion of PZ (PZ/creatinine) was also not different in patients with urolithiasis and in healthy individuals (from 54.1 ± 40.9 to 95.4 ± 69.4 ng/mg vs. 73.3 ± 36.0 ng/mg). A positive correlation was found between the plasma PZ level and creatinine‐corrected urinary PZ concentration (r = 0.46).ConclusionsBoth the plasma level and urinary excretion of PZ in urolithiasis patients were not significantly different with normal individuals. PZ detected in urinary stones as a matrix protein is thought to be incorporated into urinary stones regardless of blood and urine levels of PZ.
Recent advances in immune checkpoint inhibitors in the treatment of urothelial carcinoma: A review
Authors: Kato Minoru , Uchida Junji 
Published: August 2023

AbstractTreatment options for urothelial carcinoma were limited until the emergence of immune checkpoint inhibitors, and even now, the prognosis of metastatic disease is poor compared with the other two major genitourinary cancers, renal cell carcinoma and prostate cancer. Despite the increasing use of immune checkpoint inhibitors in the sequential treatment of urothelial carcinoma, conflicting results from similar randomized clinical trials call into question the efficacy of this treatment. In addition, physicians must be aware of the clinical characteristics of immune checkpoint inhibitors, including immune‐related adverse events, pseudo‐ and hyperprogression. This review summarizes the conflicting results of recent clinical trials and provides insights into the role of immune checkpoint inhibitors in the treatment of urothelial carcinoma.
OPA1, a molecular regulator of dilated cardiomyopathy
Authors: Chen Jiaqi , Shao Jianan , Wang Yaoyao , Wu Kangxiang , Huang Mingyuan 
Published: August 2023

AbstractDilated cardiomyopathy (DCM) is a disease with no specific treatment, poor prognosis and high mortality. During DCM development, there is apoptosis, mitochondrial dynamics imbalance and changes in cristae structure. Optic atrophy 1 (OPA1) appears at high frequency in these three aspects. DCM LMNA (LaminA/C) gene mutation can activate TP53, and the study of P53 shows that P53 affects OPA1 through Bak/Bax and OMA1 (a metalloprotease). OPA1 can be considered the missing link between DCMp53 and DCM apoptosis, mitochondrial dynamics imbalance and changes in cristae structure. OPA1 regulates apoptosis by regulating the release of cytochrome c from the mitochondrial matrix through CJs (crisp linkages, located in the inner mitochondrial membrane) and unbalances mitochondrial fusion and fission by affecting mitochondrial inner membrane (IM) fusion. OPA1 is also associated with the formation and maintenance of mitochondrial cristae. OPA1 is not the root cause of DCM, but it is an essential mediator in P53 mediating the occurrence and development of DCM, so OPA1 also becomes a molecular regulator of DCM. This review discusses the implication of OPA1 for DCM from three aspects: apoptosis, mitochondrial dynamics and ridge structure.
Gastric cancer peritoneal metastasis related signature predicts prognosis and sensitivity to immunotherapy in gastric cancer
Authors: Sun YuQin , Chen YueQing , Zhuang Wei , Fang ShunYong , Chen QiuXian , Lian MingQiao , Lv ChenBin , Weng JianMing , Wei Ran , Lin Yao , Cai LiSheng , Wang QingShui 
Published: August 2023

AbstractGastric cancer peritoneal metastases (GCPM) is a leading cause of GC‐related death. Early detection of GCPM is critical for improving the prognosis of advanced GC. Differentially expressed genes (DEGs) were identified in the GSE62254 database to distinguish between GCPM and non‐GCPM. The gastric cancer peritoneal metastases signature (GCPMs) was developed using DEGs. We analysed the effectiveness of GCPMs as indicators for prognosis, chemotherapy, and immune therapy response in GC patients. Subsequently, we analysed the correlation between GCPMs and immune microenvironment as well as immune escape in GC patients. Random forest model and immunohistochemistry was utilized to identify the crucial genes that can aid in the diagnosis of GCPM. We identified five DEGs and utilized their expression to construct GCPMs. Patients with high GCPMs had a higher likelihood of a poor prognosis, while those with low GCPMs appeared to potentially benefit more from chemotherapy. GCPMs were a dependable marker for predicting the response to immunotherapy. Additionally, GCPMs was found to be significantly linked to stromal score and cancer‐associated fibroblasts. SYNPO2 has been identified as the gene with the highest significance in the diagnosis of GCPM. Immunohistochemistry suggests that SYNPO2‐positive expression in tumour cells, fibroblasts, inflammatory cell may be associated with promoting peritoneal metastasis in GC. GCPMs have shown to be a promising biomarker for predicting the prognosis and response of GC patients to chemotherapy and immunotherapy. The use of GCPMs for individual tumour evaluation may pave the way for personalized treatment for GC patients in the future.
Cutaneous neurogenic inflammation mediated by TRPV1–NGF–TRKA pathway activation in rosacea is exacerbated by the presence of Demodex mites
Authors: Lee Sang Gyu , Kim Jihee , Lee Young In , Kim Jemin , Choi Ye Seul , Ham Seoyoon , Lee Ju Hee 
Published: August 2023

AbstractBackgroundRosacea is a common chronic inflammatory skin condition that is often refractory to treatment, with frequent relapses. Alterations in the skin immunological response and Demodex mite infestation are the primary aetiologic factors targeted for treatment. Transient receptor potential cation channel subfamily V member 1 (TRPV1) is a nociceptive cation channel that plays a role in cutaneous neurogenic pain and can be activated by various rosacea triggers.ObjectivesWe investigated the effects of TRPV1 modulation in rosacea, focussing on Demodex mite colonization and cutaneous neurogenic inflammation.MethodsWe examined mRNA expression levels according to Demodex population counts. An in vitro study using capsazepine as a TRPV1 antagonist was performed to assess the influence of TRPV1 in keratinocytes. A rosacea‐like mouse model was generated by the injection of the 37‐amino acid C‐terminal cathelicidin peptide (LL37), and changes in the skin, dorsal root ganglion (DRG) and ears were examined.ResultsIncreased Demodex mite population counts were associated with increased expression levels of TRPV1, tropomyosin receptor kinase A (TrkA) and nerve growth factor (NGF), and these levels could be reduced by capsazepine treatment in keratinocytes. In an in vivo study, the downstream effects of TRPV1 activation were investigated in the skin, DRG and ears of the rosacea‐like mouse model.ConclusionsThe findings of this study are instrumental for understanding the underlying causes of rosacea and could potentially lead to the development of new treatments targeting the NGF–TrkA–TRPV1 pathway. The identification of this pathway as a therapeutic target could represent a major breakthrough for rosacea research, potentially resulting in more effective and targeted rosacea treatments. This study contributes to an improved understanding of rosacea pathophysiology, which may lead to the development of more effective treatments in the future.
Molecular and morphological characterization of four new ancyromonad genera and proposal for an updated taxonomy of the Ancyromonadida
Authors: Yubuki Naoji , Torruella Guifré , Galindo Luis Javier , Heiss Aaron A. , Ciobanu Maria Cristina , Shiratori Takashi , Ishida Ken‐ichiro , Blaz Jazmin , Kim Eunsoo , Moreira David , López‐García Purificación , Eme Laura 
Published: August 2023

AbstractAncyromonads are small biflagellated protists with a bean‐shaped morphology. They are cosmopolitan in marine, freshwater, and soil environments, where they attach to surfaces while feeding on bacteria. These poorly known grazers stand out by their uncertain phylogenetic position in the tree of eukaryotes, forming a deep‐branching “orphan” lineage that is considered key to a better understanding of the early evolution of eukaryotes. Despite their ecological and evolutionary interest, only limited knowledge exists about their true diversity. Here, we aimed to characterize ancyromonads better by integrating environmental surveys with behavioral observation and description of cell morphology, for which sample isolation and culturing are indispensable. We studied 18 ancyromonad strains, including 14 new isolates and seven new species. We described three new and genetically divergent genera: Caraotamonas, Nyramonas, and Olneymonas, together encompassing four species. The remaining three new species belong to the already‐known genera Fabomonas and Ancyromonas. We also raised Striomonas, formerly a subgenus of Nutomonas, to full genus status, on morphological and phylogenetic grounds. We studied the morphology of diverse ancyromonads under light and electron microscopy and carried out molecular phylogenetic analyses, also including 18S rRNA gene sequences from several environmental surveys. Based on these analyses, we have updated the taxonomy of Ancyromonadida.
The Asymmetric Effect of Credit Supply on Firm‐Level Productivity Growth
Authors: MANARESI FRANCESCO , PIERRI NICOLA 
Published: August 2023

AbstractWe study the impact of bank credit on firm productivity. We exploit a matched firm‐bank database, covering all the credit relationships of Italian corporations, to measure idiosyncratic supply‐side shocks to credit availability and estimate a production model augmented with financial frictions. We find the effect of credit supply to be asymmetric: contractions harm TFP growth, halting productivity‐enhancing activities; positive credit supply shocks have limited effects. This points toward a role of financial stability in preserving productivity growth.