bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factors and Behaviors Related to Successful Transition of Care After Hospitalization for Ischemic Stroke
Authors: Dong Chuanhui , Gardener Hannah , Rundek Tatjana , Marulanda Erika , Gutierrez Carolina M. , Campo-Bustillo Iszet , Gordon Perue Gillian , Johnson Karlon H. , Sacco Ralph L. , Romano Jose G. ,   on behalf of the Transitions of Care Stroke Disparities Study (TCSD-S) Investigators†
Published: December 2022

Background:
Our objective is to describe adoption of the posthospitalization behaviors associated with successful transition of care and related baseline characteristics.

Methods:
This study includes 550 participants in the Transition of Care Stroke Disparities Study, a prospective observational cohort derived from the Florida Stroke Registry. Participants had an ischemic stroke (2018–2021), discharged home or to rehabilitation, with modified Rankin Scale score=0–3 (44% women, 24% Black, 48% White, 26% Hispanic, 35% foreign-born). We collected baseline sociodemographic and clinical characteristics. A structured telephone interview at 30-day postdischarge evaluated outcomes including medication adherence, medical appointment attendance, outpatient therapy, exercise, diet modification, toxic habit cessation, and a calculated composite adequate transition of care measure. Multivariable analyses assessed the association of baseline characteristics with 30-day behaviors.

Results:

At 30 days, medication adherence was achieved by 89%, medical appointments by 82%, outpatient therapy by 76%, exercise by 71%, diet modification by 68%, toxic habit cessation by 35%, and adequate transition of care measure by 67%. Successful adequate transition of care participants were more likely to be used full-time (42% versus 31%,
P
=0.02), live with a spouse (60% versus 47%,
P
=0.01), feel close to ≥3 individuals (84% versus 71%,
P
<0.01), have history of dyslipidemia (45 versus 34%,
P
=0.02), have thrombectomy (15% versus 8%,
P
=0.02), but less likely to have a history of smoking (17% versus 32%,
P
<0.001), coronary artery disease (14% versus 21%,
P
=0.04), and heart failure (3% versus 11%,
P
<0.01). Multivariable logistic regression analyses revealed that multiple socio-economic factors and prestroke comorbid diseases predicted fulfillment of transition of care measures. There was no difference in outcomes during the Covid-19 pandemic (2020–2021) compared with prepandemic years (2018–2019).

Conclusions:
One in 3 patients did not attain adequate 30-day transition of care behaviors. Their achievement varied substantially among different measures and was influenced by multiple socioeconomic and clinical factors. Interventions aimed at facilitating transition of care from hospital after stroke are needed.

Registration:

URL:
https://clinicaltrials.gov/
; Unique identifier: NCT 03452813.
Delivering International Criminal Justice through Domestic Law? The Case of Flight MH17
Authors: Maguire Amy , Garnham Alexandra , Elton Amy , Heaney Jessica 
Published: December 2022

Abstract
In July 2014, 298 civilians aboard Malaysia Airlines Flight MH17 were killed when their aircraft was shot down over an active war zone in eastern Ukraine. Since that time, a Joint Investigative Taskforce has worked to unearth the facts of the incident. A trial is underway in the Netherlands against four suspects accused of shooting down the passenger plane and murdering all on board, although its progress has been slowed by the COVID-19 pandemic. This article evaluates the means chosen by the Joint Investigative Taskforce and Dutch prosecutors to attribute criminal responsibility through the lens of international criminal justice. We consider the unique circumstances of the case including the collection of evidence in a conflict zone, the choice of legal forum and charges, the trial in absentia of the accused, the recognition of victims’ families’ rights to justice and the potential implication of the Russian Federation in the prosecution.
In July 2014, 298 civilians aboard Malaysia Airlines Flight MH17 were killed when their aircraft was shot down over an active war zone in eastern Ukraine. Since that time, a Joint Investigative Taskforce has worked to unearth the facts of the incident. A trial is underway in the Netherlands against four suspects accused of shooting down the passenger plane and murdering all on board, although its progress has been slowed by the COVID-19 pandemic. This article evaluates the means chosen by the Joint Investigative Taskforce and Dutch prosecutors to attribute criminal responsibility through the lens of international criminal justice. We consider the unique circumstances of the case including the collection of evidence in a conflict zone, the choice of legal forum and charges, the trial in absentia of the accused, the recognition of victims’ families’ rights to justice and the potential implication of the Russian Federation in the prosecution.
Progress in Federal Coordination to Advance Meteorological Services
Authors: Mariotti Annarita , Weaver Scott , Kannankutty Nirmala , Paese Mark , Yapur Martin 
Published: December 2022

Abstract
In 2020, the federal government completed the first major restructuring of its interagency coordination for meteorological services in over 50 years. The Interagency Council for Advancing Meteorological Services (ICAMS) now provides White House–level coordination of federal resources to advance the full suite of meteorological services now and into the future. Of particular relevance to the external community is ICAMS’ objective to strengthen and expand partnerships with nongovernment sectors. This article outlines ICAMS intellectual foundations, progress, and near-term plans, including efforts to develop a long-term strategy, as means to foster community engagement. ICAMS will continue to provide coordination across federal agencies and opportunities for input from, and engagement with, nongovernmental entities. The development of a long-term strategy is a process that ICAMS is embarking on in earnest, and sustained external community engagement is key to sound development and effective implementation.
Auroselenide, AuSe, a new mineral from Maletoyvayam deposit, Kamchatka peninsula, Russia
Authors: Tolstykh Nadezhda , Kasatkin Anatoly , Nestola Fabrizio , Vymazalová Anna , Agakhanov Atali , Palyanova Galina , Korolyuk Vladimir 
Published: December 2022

AbstractAuroselenide, ideally AuSe, is a new mineral from the Gaching ore occurrence of the Maletoyvayam deposit, Kamchatka peninsula, Russia. It occurs as anhedral grains up to 0.05 × 0.02 mm and as intergrowths up to 0.06 mm with maletoyvayamite–tolstykhite-series minerals, enclosed in native gold. Other associated minerals include pyrite, calaverite, fischesserite, gachingite, tetrahedrite-group minerals [stibiogoldfieldite, its As-analogue, tennantite-(Cu) and tetrahedrite-(Zn)], tripuhyite, minerals of the famatinite–luzonite and selenium–tellurium series, paraguanajuatite, petrovskaite, součekite and tiemannite. Auroselenide is bluish-grey, opaque with metallic lustre and grey streak. It is brittle and has an uneven fracture.Dcalc= 9.750 g/cm3. In reflected light, auroselenide is grey with a bluish shade. Bireflectance is very weak. No pleochroism and internal reflections are observed. In crossed polars, it is strongly anisotropic with bluish to brownish rotation tints. The reflectance values for wavelengths recommended by the Commission on Ore Mineralogy of the International Mineralogical Association are (Rmin/Rmax, %): 28.4/31.5 (470 nm), 30.2/33.3 (546 nm), 31.9/34.9 (589 nm) and 34.3/37.3 (650 nm). The principal bands in the Raman spectrum of auroselenide are at 93, 171, 200, 210 and 325 cm–1. The empirical formula calculated on the basis of 2 atoms per formula unit is (Au0.98Ag0.01)Σ0.99(Se0.79S0.17Te0.05)Σ1.01. Auroselenide is monoclinic, space groupC2/m,a= 8.319(1),b= 3.616(1),c= 6.276(2) Å, β = 104.54(2)°,V= 182.74(5) Å3andZ= 4. The strongest lines of the powder X-ray diffraction pattern [d, Å (I, %) (hkl)] are: 4.015 (54) (200); 3.033 (25) (${\bar 1}$11, 002); 2.780 (100) (${\bar 2}$02, 111); 2.172 (20) (${\bar 3}$11, 310); and 1.811 (25) (${\bar 1}$13). Auroselenide is the natural analogue of synthetic β-AuSe. The structural identity between them is confirmed by powder X-ray diffraction and Raman spectroscopy. The mineral is named according to its composition, as a combination of the main elements Au (aurum) and Se (selenium).
Safety and efficacy of letetresgene autoleucel alone or with pembrolizumab for relapsed/refractory multiple myeloma
Authors: Nishihori Taiga , Hoffman James E. , Huff Anne , Kapoor Gurpreet S. , Eleftheriadou Ioanna , Zajic Stefan , Urbano Alisa , Suchindran Sunil , Chisamore Michael , D’Souza Jimson W. , Faitg Thomas , Rapoport Aaron P. 
Published: December 2022

Abstract
This pilot study assessed the safety and efficacy of letetresgene autoleucel (lete-cel; GSK3377794), a genetically modified autologous T-cell therapy targeting New York esophageal squamous cell carcinoma-1 (NY-ESO-1)/L antigen family member 1 isoform A (LAGE-1a)–positive myeloma cells, alone or in combination with pembrolizumab in patients with relapsed/refractory multiple myeloma. Eligible patients expressed NY-ESO-1 and/or LAGE-1a and either HLA-A∗02:01, ∗02:05, or ∗02:06. Patients received lete-cel single infusion alone (arm 1) or with pembrolizumab (arm 2). 127 patients were screened, and 6 patients (3 per arm) were enrolled; patients in arm 1 and 2 received lete-cel alone, or with pembrolizumab, respectively. All patients exhibited grade 3/4 cytopenias, which resolved or improved to grade 1. One patient (arm 1) had grade 3/4 lete-cel–related adverse events (AEs); 2 patients (arm 2) had grade 3/4 AEs related to lete-cel and lymphodepletion. Three patients with grade 1/2 cytokine release syndrome (CRS) exhibited elevated post–lete-cel interleukin-6 levels versus those without CRS. Pooled overall response rate was 50% including 1 patient each with confirmed clinical response, very good clinical response, and partial response, and progression-free survival ranged from 1.3 to 5.2 months. Responders (arm 1: n = 1; arm 2: n = 2) had a time-to-response of 3 weeks, duration of response of 2.1 months. Two responders, but no nonresponders, exhibited elevated cytokine levels after lete-cel infusion. Lete-cel had a manageable safety profile and demonstrated clear but transient antitumor activity in patients with relapsed/refractory multiple myeloma. This trial was registered at www.clinicaltrials.gov as #NCT03168438.
Disentangling the causal relationship between rabbit growth and cecal microbiota through structural equation models
Authors: Mora Mónica , Velasco-Galilea María , Sánchez Juan Pablo , Ramayo-Caldas Yuliaxis , Piles Miriam 
Published: December 2022

Abstract
Background
The effect of the cecal microbiome on growth of rabbits that were fed under different regimes has been studied previously. However, the term “effect” carries a causal meaning that can be confounded because of potential genetic associations between the microbiome and production traits. Structural equation models (SEM) can help disentangle such a complex interplay by decomposing the effect on a production trait into direct host genetics effects and indirect host genetic effects that are exerted through microbiota effects. These indirect effects can be estimated via structural coefficients that measure the effect of the microbiota on growth while the effects of the host genetics are kept constant. In this study, we applied the SEM approach to infer causal relationships between the cecal microbiota and growth of rabbits fed under ad libitum (ADGAL) or restricted feeding (ADGR).

Results
We identified structural coefficients that are statistically different from 0 for 138 of the 946 operational taxonomic units (OTU) analyzed. However, only 15 and 38 of these 138 OTU had an effect greater than 0.2 phenotypic standard deviations (SD) on ADGAL and ADGR, respectively. Many of these OTU had a negative effect on both traits. The largest effects on ADGR were exerted by an OTU that is taxonomically assigned to the Desulfovibrio genus (− 1.929 g/d, CSS-normalized OTU units) and by an OTU that belongs to the Ruminococcaceae family (1.859 g/d, CSS-normalized OTU units). For ADGAL, the largest effect was from OTU that belong to the S24-7 family (− 1.907 g/d, CSS-normalized OTU units). In general, OTU that had a substantial effect had low to moderate estimates of heritability.

Conclusions
Disentangling how direct and indirect effects act on production traits is relevant to fully describe the processes of mediation but also to understand how these traits change before considering the application of an external intervention aimed at changing a given microbial composition by blocking/promoting the presence of a particular microorganism.
Investigating the relationship between specific executive functions and functional decline among community-dwelling older adults: results from a prospective pilot study
Authors: Verreckt Emilie , Grimm Elise , Agrigoroaei Stefan , de Saint Hubert Marie , Philippot Pierre , Cremer Gérald , Schoevaerdts Didier 
Published: December 2022

Abstract
Background
As cognitive functions and, more specifically, executive functions (EF) seem to influence autonomy among the elderly, we investigated the role of each of the five EF sub-components (inhibition, spontaneous flexibility, reactive flexibility, planning, and updating in working memory) for the risk of functional decline.

Method
A total of 137 community-dwelling participants over 75 years of age were included in a prospective cohort study and assigned to three groups: individuals with neuro-degenerative cognitive disorders, those having cognitive disorders with non-degenerative aetiology, and a control group without any cognitive problems. We measured each EF sub-component and assessed functional decline by evaluating basic (b-ADL) and instrumental activities of daily living (i-ADL) at baseline and 6 months later. We conducted three separate multiple logistic regression models to examine the extent to which the five EF facets predicted overall functional decline at the end of the follow-up period.

Results
We found that people who exhibited a decline in b-ADLs or/and i-ADLs over 6 months had worse performance on inhibition and two flexibility tasks than those who did not experience a decline. The results suggest that decliners have more difficulties in managing unforeseen events. Inhibition and updating in working memory predicted a decline in b-ADL while spontaneous and reactive flexibilities predicted a decline in i-ADL.

Conclusion
In our sample, specific executive dysfunctions were associated with a decline in functional status. With respect to the risk of decline in b-ADL, deficits in inhibition may represent a risk factor, as it regulates over-learned activities. Bothtypes of flexibility, which allow the shifting and generating of adaptive responses, predicted decline in i-ADL. In sum, paying more attention to particular EF profiles would help clinicians to anticipate some aspects of functional decline.
Artificial intelligence for the prediction of acute kidney injury during the perioperative period: systematic review and Meta-analysis of diagnostic test accuracy
Authors: Zhang Hanfei , Wang Amanda Y. , Wu Shukun , Ngo Johnathan , Feng Yunlin , He Xin , Zhang Yingfeng , Wu Xingwei , Hong Daqing 
Published: December 2022

Abstract
Background
Acute kidney injury (AKI) is independently associated with morbidity and mortality in a wide range of surgical settings. Nowadays, with the increasing use of electronic health records (EHR), advances in patient information retrieval, and cost reduction in clinical informatics, artificial intelligence is increasingly being used to improve early recognition and management for perioperative AKI. However, there is no quantitative synthesis of the performance of these methods. We conducted this systematic review and meta-analysis to estimate the sensitivity and specificity of artificial intelligence for the prediction of acute kidney injury during the perioperative period.

Methods
Pubmed, Embase, and Cochrane Library were searched to 2nd October 2021. Studies presenting diagnostic performance of artificial intelligence in the early detection of perioperative acute kidney injury were included. True positives, false positives, true negatives and false negatives were pooled to collate specificity and sensitivity with 95% CIs and results were portrayed in forest plots. The risk of bias of eligible studies was assessed using the PROBAST tool.

Results
Nineteen studies involving 304,076 patients were included. Quantitative random-effects meta-analysis using the Rutter and Gatsonis hierarchical summary receiver operating characteristics (HSROC) model revealed pooled sensitivity, specificity, and diagnostic odds ratio of 0.77 (95% CI: 0.73 to 0.81),0.75 (95% CI: 0.71 to 0.80), and 10.7 (95% CI 8.5 to 13.5), respectively. Threshold effect was found to be the only source of heterogeneity, and there was no evidence of publication bias.

Conclusions
Our review demonstrates the promising performance of artificial intelligence for early prediction of perioperative AKI. The limitations of lacking external validation performance and being conducted only at a single center should be overcome.

Trial registration
This study was not registered with PROSPERO.
Influence of ADHD, especially attention-deficit characteristics, on the course of alcohol-dependent individuals
Authors: Yoshimura Atsushi , Matsushita Sachio , Kimura Mitsuru , Yoneda Jun-ichi , Maesato Hitoshi , Yokoyama Akira , Higuchi Susumu 
Published: December 2022

Abstract
Background
While several studies have revealed that neurodevelopmental disorders have a high probability of overlapping with substance use disorders, the effects of neurodevelopmental disorders on the courses of substance use disorders have hardly been examined.

Methods
This study targeted 637 alcohol-dependent individuals who received inpatient treatment and whose drinking situations were followed for 12 months after hospital discharge using mailed questionnaires. The comorbidity of psychiatric disorders and the characteristics associated with the neurodevelopmental disorders were assessed using several measurements at the time of hospital admission. The effects of neurodevelopmental disorders on the drinking courses of the subjects were then estimated.

Results
The presence of a current depressive episode or any anxiety disorder significantly lowered the abstinence rates during the follow-up period (p = 0.0195 and p = 0.0214, respectively). ADHD traits as assessed using the ADHD Self-report Scale (ASRS) predicted a significantly poorer abstinence rate (p = 0.0296). Similarly, attention-deficit characteristics assessed objectively through interviews predicted a significantly lower abstinence rate (p = 0.0346), and a sensitivity analysis enhanced these results (p = 0.0019). When the drinking patterns were classified into three groups, the subjects with attention-deficit characteristics had a significantly higher rate of “Recurrence” and lower rates of “Abstinence” and “Controlled drinking” (p = 0.013). In a multivariate proportional hazards analysis, the ASRS score was significantly correlated with the re-drinking risk (p = 0.003).

Conclusion
ADHD traits had significant effects on not only abstinence rates, but also on drinking pattern. The presence of ADHD traits, especially attention-deficit characteristics, influenced the drinking courses of alcohol-dependent individuals after hospital treatment.
Efficacy of adjunctive intensive transcranial direct current stimulation of different cortices in treatment-resistant depression: a study protocol for a randomized double-blinded sham-controlled trial
Authors: Chen Yiming , Lyu Dongbin , Wang Fan , Huang Qinte , Yang Weichieh , Zhang Mengke , Wei Zheyi , Shi Shuxiang , Kong Shuqi , Chen Shentse , He Shuang , Yang Vivien , Fang Yiru , Hong Wu 
Published: December 2022

Abstract
Background
Treatment-resistant depression (TRD) carries a high economic burden worldwide. Transcranial direct current stimulation (tDCS) is advantageous for improving cognition and can be safely used in the treatment of depression. The effectiveness of tDCS of the left and right orbitofrontal cortex (OFC) as adjuvant treatment in patients with TRD has rarely been explored. Therefore, the objective of this trial is to evaluate the effectiveness there of when administering left dorsolateral prefrontal cortex (DLPFC) positive stimulation or OFC negative stimulation in patients with TRD.

Methods
Ninety eligible participants will be recruited to receive intervention at Shanghai Mental Health Center. Treatment will be randomly assigned in a double-blind fashion. Participants will receive either DLPFC (n = 30), OFC (n = 30), or sham (n = 30) tDCS, while continuing their usual pharmacotherapy at a stable dosage for at least 2 weeks before enrollment and throughout the stimulation period. All participants will receive 20 weekday stimulation sessions of 60 minutes duration each. Participants in the active group will be stimulated at 2 mA throughout the session, whereas the sham group will receive only a brief period of stimulation to mimic the sensation. After 20 stimulation sessions, no further treatment will be administered. Measurements will be conducted at regular points throughout and at 8 weeks after trial completion. The primary outcome is the change in the 17-item Hamilton Depression Rating Scale (HAMD-17) score after 20 sessions. Secondary outcomes were defined as changes in other measurement scales, cognitive function, resting-state functional magnetic resonance imaging (rs-fMRI), and serum biomarkers.

Discussion
We hypothesize that, in contrast to the sham group, both the active DLPFC and OFC tDCS groups will show superiority in HAMD-17 score reduction after 5, 10, and 20 sessions. Moreover, associations of the improvement of depressive symptoms with variations in rs-fMRI and TRD-related biomarkers will be evaluated. Our study may suggest that adjunctive intensive tDCS with left DLPFC positive stimulation or right OFC negative stimulation may be effective as a novel method to relieve depressive symptoms in patients with TRD. The variation of rs-fMRI, biomarkers could be used as a potential prediction model of treatment efficacy in TRD.

Trial registration
The trial protocol is registered with www.chictr.org.cn under protocol registration number ChiCTR2200058030. Date of registration: March 27, 2022. Recruitment started in September 2022 and is ongoing.