bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pathologic complete response after laparoscopic surgery following treatment with nivolumab and ipilimumab for anticancer drug-resistant MSI-high descending colon cancer: a case report and literature review
Authors: Sawayama Hiroshi , Miyamoto Yuji , Ogawa Katsuhiro , Ohuchi Mayuko , Hisano Yuki , Kato Moeko , Tubakihara Hiroki , Yoshida Naoya , Baba Hideo 
Published: December 2022

Abstract
Background
Preoperative treatment is performed for locally advanced colon cancer with extensive tumor proximity or suspected invasion of skeletal muscles, major organs, and blood vessels. Oxaliplatin-based regimens are often used in preoperative chemotherapy. However, microsatellite instability (MSI)-high colorectal cancer is often resistant to cytotoxic anticancer agents. Herein, we describe a case of treatment of anticancer drug-resistant MSI-high locally advanced colon cancer and review cases of complete response to immune checkpoint inhibitor therapy for colorectal cancer.

Case presentation
A 57-year-old woman was referred to our hospital with a large tumor in the descending colon and extensive thoracic and abdominal wall involvement, including the ribs and diaphragm. No distant metastasis was observed. The tumor had perforated the abdominal wall and formed an abscess. Upon visiting our hospital, emergency surgery was performed. An abdominal wall incision was made to drain the abscess and laparoscopic colostomy was performed. Histopathological examination of biopsy specimens revealed an adenocarcinoma with positive immunohistochemical expressions of both CDX2 and CK20. The patient was diagnosed with a descending colon cancer. Genetic examination found MSI-high, Kras mutation (F12G), and wild-type BRAF. After the inflammation improved, chemotherapy with the FOLFIRI regimen was initiated, but the tumor grew rapidly. As a second-line treatment, nivolumab and ipilimumab combination therapy was initiated. After four cycles of these therapies, the patient was administered nivolumab alone for five cycles. Tumor shrinkage was observed and radical surgery was performed. The patient underwent laparoscopic descending colon and partial thoracic and abdominal wall resection. The abdominal wall muscle was dissected from the abdominal cavity, and subcutaneous tissues, diaphragm, ribs were dissected from the body surface. Pathological examination revealed mucus components, fibrous tissues, and no malignant cells, indicating a complete pathological response (pCR). The patient had a good postoperative course and returned to work after being discharged. No recurrence was observed six months postoperatively.

Conclusions
Herein, we report a case of anticancer drug-resistant MSI-high colon cancer that was resected after treatment with immune checkpoint inhibitors, and a pCR was achieved. This new treatment strategy can be used for the treatment of cases that are not responsive to conventional therapies.
A drug delivery system constructed by a fusion peptide capturing exosomes targets to titanium implants accurately resulting the enhancement of osseointegration peri-implant
Authors: Li Xuewen , Liu Zihao , Xu Shendan , Ma Xinying , Zhao Zhezhe , Hu Han , Deng Jiayin , Peng Cheng , Wang Yonglan , Ma Shiqing 
Published: December 2022

Abstract

Background
Exosomes derived from bone marrow mesenchymal stem cells (BMSC-exos) have been shown triggering osteogenic differentiation and mineralization of MSCs, but exosomes administered via bolus injections are rapidly sequestered and cleared. Therefore, we considered the implant as a new organ of patient’s body and expected to find a method to treat implant with BMSC-exos in vivo directly.

Methods
A fusion peptide (PEP), as a drug delivery system (DDS) which contained a titanium-binding peptide (TBP) possessing the ability to selectively bind to the titanium surface and another peptide CP05 being able to capture exosomes expertly, is constructed to modify the titanium surface.

Results
Both in vitro and in vivo experiments prove PEP retains the ability to bind titanium and exosome simultaneously, and the DDS gain the ability to target exosomes to titanium implants surface following enhancing osseointegration post-implantation. Moreover, the DDS constructed by exosomes of diverse origins shows the similar combination rate and efficiency of therapy.

Conclusion
This drug delivery system demonstrates the concept that EXO-PEP system can offer an accurate and efficient therapy for treating implants with long-term effect.
Sexual risk behaviour among school-going adolescents in Sierra Leone and Liberia: a secondary analysis of the 2017 Global school-based student health surveys
Authors: James Peter Bai , Osborne Augustus , Bah Abdulai Jawo , Margao Emmanuel Kamanda , Conteh-Barrat Mohamed 
Published: December 2022

Abstract
Background
Sierra Leone and Liberia have experienced civil wars and, recently, Ebola outbreaks that led to profound economic hardship, psychopathologies and family disruptions. These factors are associated with sexual risk behaviours among youths. However, there is very little information on sexual risk behaviour among Sierra Leonean and Liberian school-going adolescents. The present study assessed the prevalence and determinants of sexual risk behaviours among school-going adolescents (10–19 years) in Sierra Leone and Liberia.

Method
We used publicly available nationally representative cross-sectional datasets of the 2017 Sierra Leone and Liberia Global school health survey. The sample consisted of 2798 and 2744 school-going adolescents from Sierra Leone and Liberia, respectively. Complex sample descriptive and regression analysis was used to analyse our data.

Results
The majority of adolescents in the two countries were involved in multiple sexual risk behaviour (80.2%), with a higher prevalence observed in Sierra Leone (85.2%) than in Liberia (75.3%). Liberian adolescents showed lesser odds of indulging in multiple sexual risk behaviours than their Sierra Leonean counterparts (AOR = 0.572; 95%CI: 0.345–0.946). Male, compared to females, were more likely to engage in multiple sexual risk behaviour (AOR = 2.310;95%CI:1.543–3.458), with a similar pattern observed in both countries. Alcohol use was associated with multiple sexual risk behaviour (AOR = 3.064; 95%CI: 2.137–4.392). Also, in Sierra Leone and Liberia, adolescents with one and two or more forms of psychological distress were more likely to have ever had sex than those who did not show any form of psychological distress. Missing class/school was associated with multiple sexual risk behaviour (AOR = 1.655; 95%CI:1.133–2.418). Peer support was only found to be a protective factor against no condom use among Liberian adolescents (AOR = 0.608; 95%CI: 0.435–0.850). Less parental support was only associated with ever had sex among adolescents in Sierra Leone (AOR = 2.027; 95%CI: 1.322–3.107) but not in Liberia (AOR = 1.034; 95%CI: 0.650–1.644).

Conclusion
Our study found a high sexual risk behaviour among school-going adolescents in Sierra Leone and Liberia. Our finding highlights the need to strengthen sexual and reproductive health education in schools and communities that incorporate mental health promotion activities tailored to this group.
Routine job dynamics in the Swiss labor market
Authors: Gschwendt Christian 
Published: December 2022

AbstractI investigate the role of labor market flows in the decline of routine employment in Switzerland between 1992 and 2018 using rich individual-level panel data from the Swiss Labour Force Survey. Existing research on the labor market effects of digital transformation has identified jobs with a high content of routine tasks as particularly prone to automation. My analysis shows that the decline in routine employment was almost entirely driven by decreasing inflow rates from non-participation and non-routine occupations as opposed to increasing outflow rates from routine jobs. Performing Oaxaca-Blinder-type nonparametric decompositions, I find that these inflow rate decreases can primarily be accounted for by changed propensities to transition into routine occupations, whereas demographic changes play a minor role. The propensity to transition from non-routine into routine employment has decreased for all distinguished demographic groups, while the propensity to enter the labor market into routine cognitive employment has particularly decreased for middle-aged individuals and those with low or medium education. My findings suggest that the Swiss labor market is evolving differently than the US labor market in the wake of the digital transformation.
Do not trust landmarks and your feelings while inserting pediatric central venous catheters
Authors: Azizov Shahin , Sahutoglu Cengiz , Bor Canan , Balcioglu Taner 
Published: December 2022

Abstract
Background
Central venous catheterization (CVC) is a commonly used procedure in pediatric surgery and intensive care units. For some reasons, catheterizations in children are technically more difficult in comparison to adult patients. The purpose of this study is to evaluate the CVC procedures performed with the aid of anatomic landmarks by experienced (35, 14, 4 years of experience) anesthesiologists and the associated complications. A total of 498 cases under the age of 18 who underwent CVC (temporary, port, or Hickman) between the years 2014 and 2017 were included in this retrospective study. All catheters were inserted with the aid of anatomic landmarks.

Results
The mean age of the patients was 47.1 ± 59.2 months and 54.8% were male. By using anatomical landmarks, the average success rate in central venous catheterizations was calculated as 98.6%. Complications developed included arterial puncture in 8% (n 40), temporary arrhythmia in 6.2% (n 31) and pneumothorax in 1.4% (n 7) of the patients. Only using multiple punctures (p = 0.005) and catheterizations lasting more than 10 min (the time to blood return from the catheter, p = 0.017) were found to be associated with complications. The experience of the practitioner had no effect on the development of complications (p = 0.354).

Conclusions
In CVCs using anatomic landmarks, complications are seen more frequently in children. Even though a decrease in overall complication rates was detected in catheterizations performed by experienced hands, it is seen that experience does not eliminate complications in CVC insertions using anatomic landmarks.
The five keys for a successful implementation of a cardiac telerehabilitation: a step-by-step effective digitalization of rehabilitation health services in Egypt
Authors: Atef Hady , Gaber Marwa , Zarif Bassem 
Published: December 2022

Abstract
Background
Telerehabilitation enables patients to communicate with physicians through the Internet and may be utilized to evaluate patients’ conditions and offer treatment plans. This method became necessary as a result of the COVID-19 pandemic and its influence on face-to-face rehabilitation choices. Many rehabilitation professionals throughout the world have turned to the ‘online’ approach, relying on smartphone and smartwatch services such as WhatsApp, Facebook, and various mobile applications that comply with the ESC requirements.

Main body
Throughout this editorial, we examine the function of cardiac telerehabilitation in light of the journalistic ‘5 W,’ taking into consideration the rising interest in this topic during the ‘COVID era.’

Conclusions
Telerehabilitation is the future of rehabilitation, particularly in the COVID age. Additionally, telerehabilitation has proved to be successful in the cardiac profession when compared to face-to-face treatments, implying that this type of rehabilitation may continue after the world is COVID-free, and forecasting that it would be the preferable choice in the future.

Graphical Abstract
POCUS, how can we include the brain? An overview
Authors: Caldas Juliana , Rynkowski Carla Bittencourt , Robba Chiara 
Published: December 2022

AbstractPoint-of-care ultrasound (POCUS) is an essential tool to assess and manage different pathologies in the intensive care unit, and many protocols have been proposed for its application in critical care literature. However, the brain has been overlooked in these protocols.Brain ultrasonography (BU) is easily available, and it allows a goal-directed approach thanks to its repeatability and immediate interpretation and provides a quick management and real time assessment of patients’ conditions. Based on recent studies, the increasing interest from intensivists, and the undeniable benefits of ultrasound, the main goal of this overview is to describe the main evidence and progresses in the incorporation of BU into the POCUS approach in the daily practice, and thus becoming POCUS-BU. This integration would allow a noninvasive global assessment to entail an integrated analysis of the critical care patients.
Non invasive hemodynamic monitoring for fluids and blood resuscitation during placenta praevia accreta cesarean delivery: a retrospective observational study
Authors: Loreto Maria , Pisanti Massimo , Celentani Marco , Pasta Gilda , Erman Alfredo , Santangelo Claudio , Giaccari Luca Gregorio , Sansone Pasquale , Villani Romolo 
Published: December 2022

AbstractBackgroundWe carry out a retrospective observational analysis of clinical records of patients with major placenta praevia who underwent cesarean section surgery over a period of 20 months in our hospital. Out of a total of 40 patients, 20 were subjected to Goal-Directed Therapy (GDT) implemented with non-invasive hemodynamic monitoring using the EV1000 ClearSight system (Group I) and 20 to standard hemodynamic monitoring (Group II). Given the risk of conspicuous blood loss, this study evaluate the impact on maternal and fetal health of GDT relative to standard hemodynamic monitoring.ResultsAverage total infusion of fluids was 1600 +/− 350 ml. Use of blood products occurred in 29 patients (72,5%), of which 11 had a hysterectomy and 8 were treated with Bakri Balloons. For 2 patients > 1000 mL of concentrated red blood cells were used. When stroke volume index SVI dropped below 35 mL/m2/beat, it responded well to the infusion of at least 2 crystalloid boluses (5 ml/kg) in 7 patients. Cardiac index (CI) increased in 8 patients in concomitance with a reduction in medium arterial pressure (MAP), but the use of ephedrine (10 mg iv) re-established acceptable baseline values. Group I means are higher than Group II means for MAP, lower for RBC usage, end-of-surgery maternal lactates and fetal pH, and for LOS. Statistical analysis determines that the null hypotheses of equalities between Groups I and II can be rejected for all measures apart from MAP at baseline and induction. Proportions of serious complications in Groups I and II are respectively 10% and 32% and Boschloo’s test rejects the null of equality of proportions against the alternative hypothesis of lower proportion of occurrence in Group I than in Group II.ConclusionsHypovolemia can lead to vasoconstriction and inadequate perfusion with decreased oxygen delivery to organs and peripheral tissues and ultimately cause organ dysfunction. Despite the small sample size due to the rarity of the pathology, our statistical analysis finds evidence in favor of more favorable clinical outcomes for patients who received GDT implemented with non-invasive hemodynamic monitoring infusion relative to patients who received standard hemodynamic monitoring.
Pilot randomised controlled trial of a remotely delivered online intervention for adolescent mental health problems in India: lessons learned about low acceptability and feasibility during the COVID-19 pandemic
Authors: Gonsalves Pattie P. , Bhat Bhargav , Sharma Rhea , Jambhale Abhijeet , Chodankar Bindiya , Verma Mamta , Hodgson Eleanor , Weiss Helen A. , Leurent Baptiste , Cavanagh Kate , Fairburn Christopher G. , Cuijpers Pim , Michelson Daniel , Patel Vikram 
Published: December 2022

Background
‘POD Adventures’ is a gamified problem-solving intervention delivered via smartphone app, and supported by non-specialist counsellors for a target population of secondary school students in India during the COVID-19 pandemic.

Aims
To evaluate the feasibility and acceptability of undertaking a randomised controlled trial of POD Adventures when delivered online with telephone support from counsellors.

Method
We conducted a parallel, two-arm, individually randomised pilot-controlled trial with 11 secondary schools in Goa, India. Participants received either the POD Adventures intervention delivered over 4 weeks or usual care comprising information about local mental health services and national helplines. Outcomes were assessed at two timepoints: baseline and 6 weeks post-randomisation.

Results
Seventy-nine classroom sensitisation sessions reaching a total of 1575 students were conducted. Ninety-two self-initiated study referrals (5.8%) were received, but only 11 participants enrolled in the study. No intervention arm participants completed the intervention. Outcomes at 6 weeks were not available for intervention arm participants (n = 5), and only four control arm participants completed outcomes. No qualitative interviews or participant satisfaction measures were completed because participants could not be reached by the study team.

Conclusions
Despite modifications to address barriers arising from COVID-19 restrictions, online delivery was not feasible in the study context. Low recruitment and missing feasibility and acceptability data make it difficult to draw conclusions about intervention engagement and indicative clinical outcomes. Prior findings showing high uptake, adherence and engagement with POD Adventures when delivered in a school-based context suggest that an online study and delivery posed the biggest barriers to study participation and engagement.
Identifying Predictors of Adherence to the Physical Activity Goal: A Secondary Analysis of the SMARTER Weight Loss Trial
Authors: BIZHANOVA ZHADYRA , SEREIKA SUSAN M. , BROOKS MARIA M. , ROCKETTE-WAGNER BONNY , KARIUKI JACOB K. , BURKE LORA E. 
Published: December 2022

ABSTRACT

Introduction/Purpose
Research is needed to inform tailoring supportive strategies for promoting physical activity (PA) in the context of behavioral treatment of obesity. We aimed to identify baseline participant characteristics and short-term intervention response predictors associated with adherence to the study-defined PA goal in a mobile health (mHealth) weight loss trial.

Methods
A secondary analysis was conducted of a 12-month weight loss trial (SMARTER) that randomized 502 adults with overweight or obesity to either self-monitoring of diet, PA, and weight with tailored feedback messages (n = 251) or self-monitoring alone (n = 251). The primary outcome was average adherence to the PA goal of ≥150 min·wk−1 of moderate- and vigorous-intensity aerobic activities (MVPA) from Fitbit Charge 2™ trackers over 52 wk. Twenty-five explanatory variables were considered. Machine learning methods and linear regression were used to identify predictors of adherence to the PA goal.

Results
The sample (N = 502) was mostly female (80%), White (82%) with the average age of 45 ± 14.4 yr and body mass index of 33.7 ± 4.0 kg·m−2. Machine learning methods identified PA goal adherence for the first week as the most important predictor of long-term PA goal adherence. In the parsimonious linear regression model, higher PA goal adherence for the first week, greater PA FB messages opened, older age, being male, higher education, being single and not having obstructive sleep apnea were associated with higher long-term PA goal adherence.

Conclusions
To our knowledge, this is the first study using machine learning approaches to identify predictors of long-term PA goal adherence in a mHealth weight loss trial. Future studies focusing on facilitators or barriers to PA among young and middle-age adults and women with low PA goal adherence are warranted.
Review and comparison of MHD wave characteristics at the Sun and in Earth’s magnetosphere
Authors: Chelpanov Maksim , Anfinogentov Sergey , Kostarev Danila , Mikhailova Olga , Rubtsov Aleksandr , Fedenev Viktor , Chelpanov Andrey 
Published: December 2022

Magnetohydrodynamic (MHD) waves play a crucial role in the plasma processes of stellar atmospheres and planetary magnetospheres. Wave phenomena in both media are known to have similarities and unique traits typical of each system.
MHD waves and related phenomena in magnetospheric and solar physics are studied largely independently of each other, despite the similarity in properties of these media and the common physical foundations of wave generation and propagation. A unified approach to studying MHD waves in the Sun and Earth's magnetosphere opens up prospects for further progress in these two fields.
The review examines the current state of research into MHD waves in the Sun’s atmosphere and Earth's magnetosphere. It outlines the main features of the wave propagation media: their structure, scales, and typical parameters. We describe the main theoretical models applied to wave behavior studies; discuss their advantages and limitations; compare characteristics of MHD waves in the Sun’s atmosphere and Earth’s magnetosphere; and review observation methods and tools to obtain information on waves in various media.
The diagnosis of periprosthetic joint infection after the arthroplasty of knee joint
Authors: Tsitko Hanna , Dudzińska Paulina , Milanowska Małgorzata , Grudzińska Aleksandra , Jarosz Dominika 
Published: December 2022

Total knee replacement is one of the most widely performed surgeries. It is stated as the most efficient method of treating end-stage osteoarthritis of the knee joint. Due to the aging of the population and the prevalence of osteoarthritis, the number of arthroplasties is increasing every day. Such extensive surgical procedures are associated with a large number of postoperative complications, one of which is periprosthetic joint infection. The reported prevalence of PJI out to 2 years after knee replacement is 1.55 %. Misconceptions in the management of periprosthetic joint infection (PJI) can compromise the treatment success. The aim of the following article was to provide an overview of the medical knowledge on the periprosthetic joint infection after the arthroplasty of knee joint.
Infections are caused by microbes that can enter the joint, which are most often coagulase-negative Staphylococci, Staphylococcus Aureus, Streptococci, Enterococci and Gram-negative bacteria. Fungal infections are much less common. The diagnostic process requires the involvement of a large group of medical personnel, which is why protocols with algorithms have been created to facilitate and standardize the diagnosis in the direction of periprosthetic joint infections. Mainly used tests from the patient's serum, synovial tests and histology. The positive results of the above tests are taken into account in the assessment of the fulfillment of the major and minor criteria to assess the likelihood of the occurrence of periprosthetic infection. This research paper aims to analyze the latest medical reports on the PJI diagnostic algorithm, laboratory and imaging studies of their effectiveness. This article was written based on analyzing data available in publications in Pubmed and Google Scholar databases