bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characterization of radiation-resistance mechanism in Spirosoma Montaniterrae DY10T in terms of transcriptional regulatory system
Authors: Cho Changyun , Lee Dohoon , Jeong Dabin , Kim Sun , Kim Myung Kyum , Sriniva Sathiyaraj 
Published: January 2023

Abstract
To respond to the external environmental changes for survival, bacteria regulates expression of a number of genes including transcription factors (TFs). To characterize complex biological phenomena, a biological system-level approach is necessary. Here we utilized six computational biology methods to infer regulatory network and to characterize underlying biologically mechanisms relevant to radiation-resistance. In particular, we inferred gene regulatory network (GRN) and operons of radiation-resistance bacterium Spirosoma montaniterrae DY10T and identified the major regulators for radiation-resistance. Our results show that DNA repair and reactive oxygen species (ROS) scavenging mechanisms are key processes and Crp/Fnr family transcriptional regulator works as a master regulatory TF in early response to radiation.
A Review of Unplanned Admissions in Head and Neck Cancer Patients undergoing Oncological Treatment
Authors: Fahy Emer , Brooker Rachel , Fleming Jason , Patterson Joanne 
Published: January 2023

Abstract
Aim
Non-surgical treatment for head and neck cancer (HNC) often results in severe toxicities, which are detrimental to patient’s health and quality of life. There is limited published UK data on unplanned hospital admissions and reasons associated with admission. We aim to identify frequencies and reasons for unplanned hospital admissions, highlighting those patient groups who are most vulnerable.
Methods
A retrospective study of unplanned hospital admissions of HNC patients receiving non- surgical treatment was completed. An inpatient admission was defined as ≥ 1 night spent in hospital. To test potential demographic and treatment predictors of inpatient admission, a multiple regression model was constructed using the end point measure (unplanned admission), as the dependent variable.
Results
A cohort of 216 patients were identified, 38 of these patients (17%) required an unplanned admission. Treatment type was the only statistically significant predictor of in-patient admission. The majority of admissions were patients receiving chemoradiotherapy (CRT) (58%) with predominant reasons for admission being nausea and vomiting (25.5%) and decreased oral intake/dehydration (30%). Of the patients admitted, 12 had a prophylactic PEG placed pre-treatment, 18 of 26 admitted without prophylactic PEG required nasogastric tube feeding during their admission.
Discussion
Almost one fifth of HNC patients over this time period required hospital admission, the majority of which can be attributed to treatment toxicities when receiving CRT. This is concurrent with other studies which review the impact of radiotherapy versus CRT. Increased support and monitoring particularly focused on nutritional is required for patients with HNC who receive CRT.
Genetic parameter estimates for daily predicted gross feed efficiency and its association with energy-corrected milk in South African Holstein cattle
Authors: Madilindi Matome Andrias , Zishiri Oliver Tendayi , Dube Bekezela , Banga Cuthbert Baldwin 
Published: January 2023

Abstract
Genetic parameters for daily predicted gross feed efficiency (pGFE) and energy corrected milk (ECM) in the first three parities of South African Holstein cattle were estimated by repeatability animal models. Data comprised of 11,068 test-day milk production records of 1,575 Holstein cows that calved between 2009 and 2019. Heritability estimates for pGFE were 0.12 ± 0.06, 0.09 ± 0.04 and 0.18 ± 0.05 in early, mid and late lactation, respectively. Estimates were moderate for primiparous (0.21 ± 0.05) and low for multiparous (0.10 ± 0.04) cows. Heritability and repeatability across all lactations were 0.14 ± 0.03 and 0.37 ± 0.03, respectively. Genetic correlations between pGFE in different stages of lactation ranged from 0.87 ± 0.24 (early and mid) to 0.97 ± 0.28 (early and late), while a strong genetic correlation (0.90 ± 0.03) was found between pGFE and ECM, across all lactations. The low to moderate heritability estimates for pGFE suggest potential for genetic improvement of the trait through selection, albeit with a modest accuracy of selection. The high genetic correlation of pGFE with ECM may, however, assist to improve accuracy of selection for feed efficiency by including both traits in multi-trait analyses. These genetic parameters may be used to estimate breeding values for pGFE, which will enable the trait to be incorporated in the breeding objective for South African Holstein cattle.
Joint effect of human papillomavirus exposure, smoking and alcohol on risk of oral squamous cell carcinoma
Authors: Yang Zheng , Sun Peng , Dahlstrom Kristina R , Gross Neil , Li Guojun 
Published: January 2023

Abstract
Background: Smoking, alcohol consumption, and human papillomavirus (HPV) infection are known risk factors for oral cancer. Researchers have examined each of these risk factors independently, but few have observed the potential risk of their interaction. In this study, we investigated the interactions among smoking, alcohol consumption, and HPV exposure and their effect on risk of oral cancer.
Methods: Totally 377 patients with newly diagnosed oral cancer and 433 cancer-free controls who were frequency-matched by age and sex were included. Multivariable logistic regression analysis was performed to calculate odds ratios (ORs) and 95% confidence intervals (CIs).
Results: Consistent with historical evidence, we found that oral cancer risk was independently associated with smoking (adjusted OR(aOR): 1.3, 95% CI: 1.0-1.9), alcohol consumption (aOR: 1.4, 95% CI: 1.1-2.0), and HPV16 seropositivity (aOR: 3.3, 95% CI: 2.2-4.8), respectively. Additionally, we found that HPV16 seropositivity increased the risk of oral cancer in ever-smokers (aOR: 6.4, 95% CI: 3.3-12.7) and ever-drinkers (OR: 4.4, 95% CI: 2.6-7.3), while HPV16-seronegative ever-smokers and ever-drinkers had less than a twofold increase in risk of oral cancer (aORs: 1.1, 95% CI: 0.8-1.7 and 1.6, 95% CI: 1.1-2.4, respectively). Furthermore, the increased risk was particularly high for oropharyngeal cancer in HPV16-seropositive ever-smokers (aOR: 12.3, 95% CI: 5.7-26.3) and in HPV16-seropositive ever-drinkers (aOR: 9.8, 95% CI: 5.3-18.3).
Conclusion: These results suggest a strong combined effect of HPV16 exposure, smoking, and alcohol on oral cancer, which may indicate a strong interaction between HPV16 infection and smoking and alcohol consumption, particularly for oropharyngeal cancer.
Social media analytics and their applications to evaluate an activity in online health interventions using CRITIC and TOPSIS Techniques
Authors: Lin Yushan , Alshehri Yasser , Alnazzawi Noha , Abid Mohammad , Khan Samina A. , Jabeen Fouzia , Elwarfalli Ibrahim 
Published: January 2023

Abstract
The usage of social media is increasing by leaps and bounds in our day-to-day lives. It affects daily routines and brings a lot of change in different departments like health and education systems during the COVID-19 pandemic. Healthcare research and practice have been significantly impacted by the astounding growth of social media. Social media are changing health information management in several ways, from offering appropriate ways to enhance healthcare professional contact and share health-related knowledge and experience to facilitating the development of innovative medical research and wisdom. Social media analytics (SMAs) are efficient and effective interaction instruments that can be useful for both patients and clinicians in health interventions. Moreover, a significant portion of those involved in clinical practices (such as clinicians, professional colleges, and departments of health) are unaware of the importance of social media, its potential applications in their daily lives, as well as the possible consequences and how these will be handled. In the presented study, we proposed MCDM-based approaches known as “Criteria Importance Through Inter Correlation” (CRITIC) and Technique for Order of Preference by Similarity to Ideal Solution (TOPSIS) in order to identify the effective alternative among several options and make a better decision. After extracting features from the literature review, we choose six significant and relevant features and assign weights to them using CRITIC techniques while utilizing the TOPSIS technique to rank the alternatives based on their performance values. After the implementation of both methods and evaluation procedure, it is determined that the alternative with the highest score is placed at the top and called the "best alternative," while the alternative with the lowest score is placed at the bottom and called the worst alternative. Finally, we suggest a variety of research initiatives and new research areas where the aforementioned procedures becomes extremely useful in evaluating SMAs and their uses in online health interventions.
Multiple Switching and Bifurcations of In-phase and Anti-phase Periodic Orbits to Chaos Coexistence in a Delayed Half-center CPG Oscillator
Authors: Song Zigen , Xu Jian 
Published: January 2023

Abstract
In this study, we investigate complex dynamical behaviors of a delayed HCO (half-center oscillator) neural system consisted of two inertial neurons. The neural system proposes two types of periodic orbits with in-phase and anti-phase spatiotemporal patterns that arise via the Hopf bifurcation of the trivial equilibrium and the homoclinic orbit (Homo) bifurcation of the nontrivial equilibrium. With increasing time delay, the periodic orbit translates into a quasi-periodic orbit and enters chaos attractor by employing the quasi-periodic orbit bifurcation. Further, the chaos attractor breaks and bifurcates into a pair of symmetry multiple-periodic orbits, which evolves into a pair of symmetry chaos attractors by the period-doubling bifurcation. The delayed HCO neural system presents multiple coexistence employing two classical bifurcation routes to chaos, i.e. the quasi-periodic orbit and period-doubling bifurcations. What is interesting is that the delayed HCO neural system proposes seven similar sequences (maybe up to infinity) of the bifurcation routes to chaos with the increasing of the variable bifurcation parameter τ. In the presented paper, we just exhibit 14 attractors’ coexistence induced by the multiple bifurcation routes, which includes periodic orbits, quasi-periodic orbits, chaos attractors, and multiple-periodic orbits.
Occludin regulates HIV-1 infection by modulation of the interferon stimulated OAS gene family
Authors: Torices Silvia , Teglas Timea , Naranjo Oandy , Fattakhov Nikolai , Frydlova Kristyna , Cabrera Rosalba , Osborne Olivia M. , Sun Enze , Kluttz Allan , Toborek Michal 
Published: January 2023

Abstract
HIV-1-associated blood brain barrier (BBB) alterations and neurocognitive disorders are frequent clinical manifestations in HIV-1 infected patients. The BBB is formed by cells of the neurovascular unit (NVU) and sealed together by tight junction (TJ) proteins, such as occludin (ocln). Pericytes are a key cell type of NVU that can harbor HIV-1 infection via a mechanism that is regulated, at least in part, by ocln. After viral infection, the immune system starts the production of interferons, which induce the expression of the 2'-5'-oligoadenylate synthetase (OAS) family of interferon stimulated genes and activate the endoribonuclease RNaseL that provides antiviral protection by viral RNA degradation. The current study evaluated the involvement of the OAS genes in HIV-1 infection of cells of NVU and the role of ocln in controlling OAS antiviral signaling pathway. We identified that ocln modulates the expression levels of the OAS1, OAS2, OAS3, and OASL genes and proteins and, in turn, that the members of the OAS family can influence HIV replication in human brain pericytes. Mechanistically, this effect was regulated via the STAT signaling. HIV-1 infection of pericytes significantly upregulated expression of all OAS genes at the mRNA level but selectively OAS1, OAS2 and OAS3 at the protein level. Interestingly no changes were found in RNaseL after HIV-1 infection. Overall, these results contribute to a better understanding of the molecular mechanisms implicated in the regulation of HIV-1 infection in human brain pericytes and suggest a novel role for ocln in controlling of this process.
Transcriptomic insights into the genetic basis of improved Fusarium crown rot resistance during wheat allohexaploidization
Authors: Chen Ying , Wang Yunpeng , Guan Fangnian , Long Li , Wang Yuqi , Li Hao , Deng Mei , Zhang Yazhou , Pu Zhien , Li Wei , Jiang Qiantao , Wang Jirui , Wei Yuming , Ma Jian , Xu Qiang , Kang Houyang , Qi Pengfei , Yuan Zhongwei , Zhang Lianquan , Liu Dengcai , Zheng Youliang , Chen Guoyue , Jiang Yunfeng 
Published: January 2023

Abstract
Background
Fusarium crown rot (FCR) is a chronic disease of cereals worldwide. Compared with tetraploid wheat, hexaploid wheat is more resistant to FCR infection, but little is known about the contributions of allohexaploidization to wheat FCR resistance. In this study, we compared FCR responses of 10 synthetic hexaploid wheats (SHWs) and their tetraploid and diploid parents and then further analyzed transcriptome data from two SHWs and their parents.
Results
We observed that stronger FCR resistance emerged immediately in the SHWs following allohexaploidization. The transcriptome analysis suggested that multiple defense pathways responsive to FCR infection were stronger in the SHWs than in the parents. In particular, dozens of phenylalanine ammonia lyase (PAL) genes, involved in lignin and salicylic acid (SA) biosynthesis, exhibited a higher degree of response to FCR infection in the SHWs. Physiological measurements later confirmed that PAL activities and SA and lignin contents of the stem bases of the SHWs were higher than those of the tetraploid parents.
Conclusion
Overall, these findings imply that the stronger FCR resistance of hexaploid wheat compared with tetraploid wheat is probably due to changes in PAL-mediated lignin and SA biosynthesis pathways after allohexaploidization.
Contact with primary care physicians among adults with pre-existing common mental health problems during the COVID-19 pandemic: a registry-based study from Norway
Authors: Jensen Pia , Madsen Christian , Hauge Lars Johan , Gustavson Kristin , Lund Ingunn Olea , Pettersen Johanne Hagen , Knudsen Ann Kristin Skrindo , Reneflot Anne , Brandlistuen Ragnhild Eek , Valdimarsdóttir Unnur Anna , Ask Helga , Nesvåg Ragnar 
Published: January 2023

AbstractBackground: During the COVID-19 pandemic, individuals with pre-existing mental health problems may have experienced additional stress, which could worsen symptoms or trigger relapse. Objective: To investigate if the number of consultations with general practitioners (GPs) among individuals with a pre-existing common mental health problem during the pandemic differed from pre-pandemic years. Methods: Data on consultations with GPs among 18-65-year-olds registered with common mental health problems in 2017-2021 were retrieved from the Norwegian Control and Payment of Health Reimbursement register. Based on data from the pre-pandemic years (2017-2019), we predicted the number of consultations per week for depression, anxiety disorder, phobia/obsessive-compulsive disorder (OCD), post-traumatic stress disorder (PTSD), and eating disorders during the pandemic (March 2020-December 2021) among individuals with pre-existing mental health problems. The forecasted and observed trends in GP consultations per week during the pandemic were stratified by diagnosis, gender, and age groups. Results: The observed number of consultations for anxiety disorder, PTSD, and eating disorders were significantly higher than forecasted during extended periods of the two pandemic years. The differences were largest for PTSD (on average 37% higher in men and 47% higher in women during the pandemic), and for eating disorders among women (on average 87% higher during the pandemic). There were only minor differences between the predicted and observed number of consultations for depression and phobia/OCD. Conclusions: During the pandemic, individuals with a recent history of mental health problems were more likely to seek help for anxiety disorder, PTSD, and eating disorders, as compared to pre-pandemic years.
Performance Comparison of Lithium Polymer Battery SOC Estimation Using GWO-BiLSTM and Cutting-Edge Deep Learning Methods
Authors: Taş Göksu , Bal Cafer , Uysal Ali 
Published: January 2023

Abstract
In this study, the GWO-BiLSTM method has been proposed by successfully estimating the SOC with the BiLSTM deep learning method using the hyper-parameter values determined by the GWO method of the lithium polymer battery. In studies using deep learning methods, it is important to solve the problems of underfitting, overfitting, and estimation error by determining the hyper-parameters appropriately. EV, HEV, and robots are used more healthily with the successful, reliable, and fast SOC estimation, which has an important place in the Battery Management System. The success of the proposed method was verified by comparing the cutting-edge data-based deep learning methods and the BiLSTM method with the SOC estimation MAE, MSE, RMSE, and Runtime(s) metrics. In the comparison, the prediction successes of the BiLSTM method, which was trained with the optimal hyper-parameter values obtained by the GWO method, with the cutting-edge deep learning methods trained with the hyper-parameter values obtained through trial and error were compared. The GWO-BiLSTM method was the most successful method with RMSE of 0.09244% and R2 of 0.9987 values according to the average results of SOC estimation made with the lithium polymer battery data set, which was created by experiments performed at different discharge levels and is new in the literature.
Glycolaldehyde-derived advanced glycation end products promote macrophage proliferation via the JAK-STAT signaling pathway
Authors: Toyomura Takao , Watanabe Masahiro , Wake Hidenori , Nishinaka Takashi , Hatipoglu Omer Faruk , Takahashi Hideo , Nishibori Masahiro , Mori Shuji 
Published: January 2023

Abstract
Background: Advanced glycation end products (AGEs) are heterogeneous proinflammatory molecules produced by a non-enzymatic glycation reaction between reducing sugars (and their metabolites) and biomolecules with amino groups, such as proteins. Although increases in and the accumulation of AGEs have been implicated in the onset and exacerbation of lifestyle- or age-related diseases, including diabetes, their pathophysiological functions have not yet been elucidated in detail.
Methods and Results: The present study investigated the cellular responses of the macrophage cell line RAW264.7 stimulated by glycolaldehyde-derived AGEs (Glycol-AGEs) known as representative toxic AGEs. The results obtained showed that Glycol-AGEs significantly promoted the proliferation of RAW264.7 cells at a low concentration range (1-10 µg/mL) in a concentration-dependent manner. On the other hand, neither TNF-α production nor cytotoxicity were induced by the same concentrations of Glycol-AGEs. The increases observed in cell proliferation by low concentrations of Glycol-AGEs were also detected in receptor triple knockout (RAGE-TLR4-TLR2 KO) cells as well as in wild-type cells. Increases in cell proliferation were not affected by various kinase inhibitors, including MAP kinase inhibitors, but were significantly suppressed by JAK2 and STAT5 inhibitors. In addition, the expression of some cell cycle-related genes was up-regulated by the stimulation with Glycol-AGEs.
Conclusions: These results suggest a novel physiological role for AGEs in the promotion of cell proliferation via the JAK-STAT pathway.
Ring-shaped traveling wave Zeeman decelerator for both light and heavy molecules
Authors: Ji Yabing , Liu Qing , Liu Yang , Yang Tao , Hou Shunyong , Yin Jianying 
Published: January 2023

Abstract
Taming more species of molecules with large density is a long-standing goal in molecular science. Heavy molecule (> 100 amu) is of particular interest for precision measurements. However, decelerating a fast-moving beam of heavy molecules to rest remains challenging for Zeeman deceleration. Additionally, the traditional approach of pulsed Zeeman decelerator suffers from serious molecular loss during deceleration, significantly limiting its potential applications. Herein, we present a ring-shaped traveling wave Zeeman decelerator (RTWZD) featured with true three-dimensional smoothly-moving magnetic potential wells that directly solve the above intractable problems. With this approach, not only the density of the molecule can be greatly increased but also the range of molecular species for Zeeman deceleration can be extended from light to heavy. The performance of the RTWZD is characterized with both the theoretical analysis and the numerical calculation, where a group of atoms and molecules such as 7Li, 32O2, 88Sr19F and 174Yb19F are employed as testers. Losses in the traditional Zeeman decelerator can be avoided, yielding more than two orders of magnitude improvement in molecular density. These characteristics of the RTWZD make it an ideal toolbox to produce cold and dense atomic/molecular samples, enabling promising prospects for cold collision, sympathetic cooling, and precision measurement.
Relationship of the structural, mechanical and tribological behavior among TiCN, BCN, and CrAlN coatings in the fatigue life of AISI 1045 steel for automotive industry
Authors: Jácome Juan Francisco Correa , Angulo Julio César Caicedo 
Published: January 2023

Abstract

This work links the relationship between the structural, morphological, mechanical and tribological behaviors with the rotary fatigue life performances of AISI 1045 steel substrates coated with Titanium Carbo-nitride (TiCN), Chromium Aluminum Nitride (CrAlN) and Boron Carbon Nitride (BCN) through PVD. Appropriate conditions of the deposition of the coatings allowed to obtain improved properties. These coatings were deposited on AISI 1045 steel substrates. Singular layers of the different coatings were used, with a stable layer thickness of ~ 3 µm. The influence of the coating type on the crystal structure, bond energies, and microstructural properties were established by X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS) and scanning electron microscopy (SEM). Mechanical properties such as hardness and modulus of elasticity of the coatings were determined by nanoindentation. Tribological characterization techniques were used to determine friction coefficients. For the rotary fatigue test, the following ratios, 70%, 65%, 60% and 55% of the ultimate stress value, were chosen to determine the applied stress levels. For all three coatings an increase in fatigue strength was found: 9.625% for TiCN, 4.215% for BCN and 3.954% for CrAlN. The increase in mechanical properties together with the lower presence of residual stresses in the coatings justifies the increase in fatigue resistance.