bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pemodelan Produk Domestik Regional Bruto Sektor Pertanian dan Penyaluran Kredit menggunakan Two Stage Least Square
Authors: Saputri Prilyandari Dina , Oktaviana Pratnya Paramitha 
Published: July 2023

Green economy is a concept relating to economic development which aimed to improve people's welfare by paying attention to environmental conditions. One main pillar of a green economy is economic growth which can be calculated through GDP (Gross Domestic Product). Financial institutions can play an important role in raising economic growth through optimal credit allocation. The causal relationship that influences each other between credit allocation and Gross Regional Domestic Product (GRDP) in the agricultural, hunting, forestry, and fisheries sectors can be analyzed using the simultaneous two stage least square equation. The variables that significantly affect credit allocation are the percentage of NPL and GRDP, while the variables that significantly affect GRDP are the area of agricultural land and credit allocation. A significant causal relationship between credit distribution and GRDP shows that financial institutions can play a role in raising the growth of the green sector economy through credit allocation, especially in the green sector.

Ekonomi hijau merupakan gagasan mengenai pengembangan perekonomian yang bertujuan meningkatkan kesejahteraan masyarakat dengan memperhatikan kondisi lingkungan. Salah satu pilar utama dalam ekonomi hijau adalah pertumbuhan ekonomi yang dapat dihitung melalui PDB (Produk Domestik Bruto). Lembaga keuangan dapat memegang peranan penting dalam peningkatan pertumbuhan ekonomi melalui penyaluran kredit yang optimal. Hubungan kausalitas yang saling mempengaruhi antara penyaluran kredit dengan PDRB sektor pertanian, perburuan, kehutanan, dan perikanan dapat dianalisis menggunakan persamaan simultan two stage least square. Variabel yang mempengaruhi penyaluran kredit secara signifikan adalah variabel persentase NPL dan PDRB, sedangkan variabel yang mempengaruhi PDRB secara signifikan adalah luas lahan pertanian dan penyaluran kredit. Hubungan kausalitas yang signifikan antara penyaluran kredit dengan PDRB menunjukkan bahwa lembaga keuangan dapat berperan dalam meningkatkan perkembangan perekonomian sektor hijau melalui penyaluran kredit, khususnya pada sektor hijau.
International Comparison and Insights on Sustainable Competitiveness of Water Industry Management Models: Evidences from France and China
Authors: Zhang Wenjing , Deng Bangwu , Yang Xue , TIAN Kang 
Published: July 2023

Abstract
The sustainability of the water industry management model is one of the essential means to achieve sustainable utilization of water resources. Based on existing research on the sustainability of water industry, this study explores the factors affecting the sustainable competitiveness of water industry management model and constructs a more complete sustainable competitiveness evaluation indicator system. Evidences taken from France and China were selected as the references for the study, and the principal component analysis was used to evaluate the overall sustainable competitiveness and main component dimensions. It is found through this study that the overall competitiveness indicator in sustainable water industry management model, and the sub-dimensional competitiveness indicators in resource support, development base, and environmental impact of the water industry of France are better than that of China. While China shows more competitive in social inclusion, technological innovation, and sustainability of the water industry. Based on the research results, this study provides the insights to solve the existing issues in the sustainable development of China's water industry to support how China can adjust its water industry management model to improve its sustainable competitiveness.
Identification of memory B cell-associated miRNA signature to establish a prognostic model in gastric adenocarcinoma
Authors: Liu Ruquan , Huang Biaojie , Shao Yongzhao , Cai Yongming , Liu Xi , Ren Zhonglu 
Published: July 2023

Abstract
Background
Memory B cells and microRNA (miRNA) play important roles in the progression of gastric adenocarcinoma (STAD). However, there are few studies on utility of memory B cell-associated miRNAs for prognosis of STAD.
Methods
We identified the marker genes of memory B cells by single-cell RNA sequencing (scRNA-seq) and identified the miRNAs associated with memory B cells by constructing an mRNA-miRNA co-expression network. Then, univariate Cox, random survival forest (RSF), and stepwise multiple Cox regression (StepCox) algorithms were used to identify memory B cell-associated miRNAs that were significantly related to overall survival (OS). A prognostic risk model was constructed and validated using these miRNAs, and patients were divided into a low-risk group and a high-risk group. In addition, the differences in clinicopathological features, tumour microenvironment, immune blocking therapy, and sensitivity of anticancer drugs in the two high versus low risk groups were analyzed.
Results
Four memory B cell-associated miRNAs (hsa-mir-145, hsa-mir-125b-2, hsa-mir-100, hsa-mir-221) with significantly correlation to OS were identified and used to construct a prognostic model. Time-dependent receiver operating characteristic (ROC) curve analysis confirmed the feasibility of the model. Kaplan-Meier (K-M) survival curve analysis showed that the prognosis was poor in the high-risk group. The comprehensive analysis showed that the patients in the high-risk group have higher immune scores, matrix scores, immune cell infiltration, and poor effect of immune response. In addition, in terms of drug screening, we predicted eight drugs with higher sensitivity in the high-risk group, of which CGP-60474 was the most sensitive.
Conclusions
In summary, we identified memory B cell-associated miRNAs prognostic features and constructed a novel risk model for STAD based on scRNA-seq data and bulk RNA-seq data. Patients in the high-risk group showed the highest sensitivity to GCP-60474. This study provides prognostic insights for individualized and accurate treatment of STAD patients.
Cryospheric melting enhances methane emissions from inland waters on the Tibetan Plateau
Authors: Gao Tanguang , Zhang Yulan , Wei Da , Zhao Yanlong , Liu Zhiyin , Sillanpää Mika 
Published: July 2023

Abstract
Inland waters over the Tibetan Plateau (TP) are significant sources of atmospheric methane (CH4), which plays a critical role in the regional carbon cycle. Rapid climate warming on the TP has caused siginficant cryosphere retreating during the past decades, mainly including the glacier melting and permafrost thawing. They are changing inland water status, as evidenced by the increasing river runoff, enpanding lake areas, emerging glacier lakes and permafrost thermokarst lakes. These substantial changes have resulted in enhanced CH4 emissions. The estimated CH4 emissions from inland waters on the TP vary from 1.8–3.4 Tg CH4 yr-1. However, there remains a lack of sufficient CH4 data from glacier lakes, permafrost thermokarst lakes, and river headwaters on the TP, which urgently needs to be systematically measured. Morewover, we highlight the possible impact of on gong warming-induced cryospheric melting on CH4 emissions from inland waters over the TP.
Ovarian stimulation Altered Uterine Fluid Extracellular Vesicles miRNA Affecting Implantation in Rats
Authors: Huang Xi , Zhao Jing , Zhang Qiong , Wang Yonggang , Li Yanping 
Published: July 2023

Abstract
Purpose: Uterine fluid (UF) extracellular vesicle (EV) miRNA may affect implantation and could be the potential biomarker of endometrial receptivity (ER). Ovarian stimulation (OS) could damage the ER but its mechanism is still unclear. Here, we evaluate the affections of OS on UF EV miRNA expression and implantation.
Methods: Female rats were divided into three groups: natural cycle or injection with GnRH-a following HP-HMG or u-FSH and collected UF on the 5th day of gestation. The affinity membrane column was used to isolate EVs from UF, which was collected by flushing during implantation. EVs miRNAs were sequenced, and five among them were verified by qRT–PCR.
Results: In OS groups, the implantation rate decreased (p<0.05), and the pinopode was damaged in the OS groups. The EVs were isolated from UF, and the differential expression key miRNAs were involved in several regulation pathways, such as cancer, endocrine, and cell cycles, which were correlated with ER and implantation. Among the miRNAs, miR-223-5p greatly differed and was most consistent with the sequencing results, followed by miR-223-3p and miR-98-5P.
Conclusion: OS altered UF EVs miRNAs affecting implantation in rats, and miR-223 might be the key molecule. Our results enriched EV data in the fertility research field and broadened our knowledge of OS and implantation.
Remote sensing assessment of multi-year drought vulnerability of agriculture in Kangavar, Kermanshah Province, west of Iran
Authors: Buzhani Farzaneh Imani , Sadr Maryam Kiani , Sobhanardakani Soheil , Lorestani Bahareh , Cheraghi Mehrdad 
Published: July 2023

Abstract

The current study investigated the spatiotemporal distribution and detection of drought severity using ground indices in R-Studio software and applying indices on the images of Landsat 8 and Sentinel 2 satellites in the growing season and annually. The outcomes showed that typical months had the largest range in terrestrial indices results, and the NDVI index had the greatest compatibility with SPEI. By comparing these two times, during the growing season, plant health was evident in the northwest and in annual images in the northeast. Moreover, a negative correlation was found between LST and NDVI in elevation, which was more moderate at northern heights. High mean annual temperatures during growing seasons were common in the east and south. The eastern side of the study area had high annual vegetation density, but soil moisture was higher in the southwest. Floods negatively affected plant health; with the 2019 flood, the canola yield was very low. In summary, Sentinel 2 images showed drought better in the growing season and Landsat 8 images showed drought better in the dry season or at the end of plant growth.
Processing Parameters Impact on Microstructure and Mechanical Properties of ASTM A36 Steel Laser Welding
Authors: Fissmer Elton Eduardo , Dreveck Natália Wendt , Filho Osmar Custódio de Moura , Ferraresi Henrique Nardon , Rabelo Alexsandro 
Published: July 2023

Abstract
In recent years there have been advances in the development of processes for obtaining and building steel and metal alloys. These developments require an increasingly deeper and more detailed understanding of the phenomena that involve phase transformations, arising from the processing of obtaining, forming, welding and application of these materials. At the same time, the evolution of laser welding technologies is making these processes increasingly attractive for industrial applications. In this context, this work proposes to study the effect of different combinations of parameters on the visual, mechanical and microstructural characteristics of the laser welding beads. To evaluate the influence of process parameters, 8 combinations of speed and power were used, keeping the heat input constant, in the welding of ASTM A36 steel. The study aims to compare the influence of the variation of these parameters in the weld region and its relationship with the mechanical properties, considering that, despite the constant heat input, there is still a variation in the power density and the interaction time. The results indicate that the material used has a wide processing window, since the tensile tests, microhardness and metallographic analyzes showed similar results in the range of evaluated parameters. Samples welded with powers between 2 kW and 8 kW showed good mechanical performance, but an increase in process instability was observed, with an increase in power density and a reduction in the interaction time.
First true mastodon from the Late Miocene of Western Asia
Authors: Yaghoubi Sadaf , Ashouri Ali Reza , Ataabadi Majid Mirzaie , Ghaderi Abbas 
Published: July 2023

Abstract

A mammutid is described here for the first time from the Late Miocene (MN12 equivalent) deposits of Abkhareh village, Varzeghan region in the northwestern part of Iran. It is identified as “Mammut” cf.obliquelophusand is represented by an isolated and moderately worn upper third molar with zygodont crown pattern as typical of mammutids. In addition, two upper incisors found associated with the molar and probably belonging to the same individual are assigned asMammut. The studied material expands the geographic distribution of“Mammut” obliquelophusinto western Asia.
Effects of Heart Rate Variability Biofeedback on Indicators of Self-Regulation and Performance in Brazilian Police Officers
Authors: Pinc Tânia 
Published: July 2023

Abstract

This article examines the effects of a heart rate variability biofeedback protocol on self-regulation and performance indicators in Brazilian police officers. The biofeedback protocol lasted for five days and was combined with operational training Participants were preselected and divided into two groups: control group (26 officers) and treatment group (26 officers). The study assessed all participants before and after the intervention, measuring their self-regulation (maximum heart rate) and performance (procedures and response time) in a controlled environment that simulated an armed reaction situation. Significant effects were observed in the treatment group, aligning with the hypothesized direction. There was a decrease in maximum heart rate, indicating self-regulation, as well as a reduction in procedural failures and response time, indicating enhanced performance. The findings suggest that exclusive reliance on police training may be insufficient for enhancing performance. Instead, the ability to promote self-regulation through heart rate variability biofeedback emerges as a crucial factor. The purpose of the research was to gather evidence for public policy implementation in the city of Barueri, state of São Paulo, Brazil.
Perceived health inequalities: Are the UK and US public aware of occupation-related health inequality, and do they wish to see it reduced?
Authors: Bridger Emma K , Tufte-Hewett Angela , Comerford David 
Published: July 2023

Abstract

Background. One underexamined factor in the study of lay views of socioeconomic health inequalities is occupation-related health. Examining health by occupational social class has a long history in the UK but has been comparatively overlooked in US public health literatures. Methods. Representative samples of the UK and US indicated the perceived and ideal lifespan of people working in “higher managerial/professional” and “routine” occupations. We examine perceptions of inequality and desires for equality across occupation groups as a function of country and key socio-demographic variables. Results. 67.8% of UK and 53.7% of US participants identified that professionals live longer than routine workers. Multivariate models indicated that US participants were markedly less likely to be aware of occupation-related inequalities after controlling for age, gender, and education. Awareness was negatively related to age (in the US) and recent voting behaviours (both samples). Desiring equal life expectancy was less likely in the US sample, and less likely across both samples for older participants and those with lower levels of education. Conclusion. There is widespread understanding of the occupation-related gradient in lifespan and a desire that these inequalities be eliminated in the UK, but considerably less awareness and desire for equality in the US.
Deciphering a hydrogen sulfide-related signature to supervise prognosis and therapeutic response in colon adenocarcinoma
Authors: Chen Jinbiao , Zhang Yingchun 
Published: July 2023

Abstract
Background: Hydrogen sulfide (H2S) is a critical molecule that participates in various molecular, physiological, and pathophysiological processes in biological systems. Emerging evidence has revealed that H2S is implicated in the progression of colon cancer and immune escape. Against this backdrop, the present study aimed to construct a prognostic risk feature for colon adenocarcinoma (COAD) by leveraging H2S-related genes (HSRG).
Methods: Transcriptomic data and corresponding clinical-pathological information of colon cancer were obtained from TCGA and GEO databases. Univariate Cox regression analysis was employed to assess the prognostic relevance of HSRG. Consensus clustering was utilized to perform molecular subtyping of COAD, followed by comparison of immune cell infiltration, drug sensitivity, and immune therapy response between subtypes. Differential expression gene and gene set enrichment analyses were conducted between subtypes. Univariate, lasso, and multivariate Cox regression analyses were applied to construct a prognostic model derived from HSRG. A nomogram model for predicting COAD prognosis was constructed and evaluated.
Results: In this study, we identified 12 HSRGs that were associated with COAD prognosis. Consensus clustering analysis revealed 3 COAD molecular subtypes that exhibited significant differences in terms of prognosis, tumor immune cell infiltration, drug sensitivity, and immune therapy response. Gene set enrichment analysis demonstrated that immunoregulatory processes were significantly suppressed in the poor-prognosis subtype while Wnt-related pathways and processes were significantly upregulated. Based on the differentially expressed genes between subtypes, we constructed a risk model comprising 11 genes that effectively distinguished high-risk patients from low-risk patients with significant associations with patient survival outcomes, drug treatment, pathological staging, and T staging. The HSRG-derived risk feature was an independent prognostic factor for COAD in drug treatment and pathological staging and could be integrated into a nomogram for prognosis prediction. Calibration curve, receiver operating characteristic curve (ROC), and decision curve analysis demonstrated excellent performance of the nomogram in evaluating COAD prognosis.
Conclusion: Our study systematically assessed the prognostic significance of HSRG in COAD, identified HSRG-based molecular subtypes and risk features, and highlighted their potential utility in predicting prognosis and treatment response.
Encapsulated Docetaxel in Synthesized PCL-PEG-PCL Nano-Carriers as a Strategy for Controlled Drug Delivery in Breast Cancer
Authors: Khojastehfar Ali , Zabihi Ebrahim , Mostafazadeh Amrollah , Janbabaei Ghasem , Hakemi Pejman , Nataj Hadi , Mahjoub Soleiman 
Published: July 2023

Abstract
Background
Nano-drug delivery systems are rapidly evolving in the treatment of cancer due to reduced side effects and improved therapeutic properties of drugs through the drugs’ slow release and as a result, enhancing permeability and retention of drugs.
Methods and Results
Encapsulated docetaxel in PCL-PEG-PCL nano-carrier (P1) was prepared by the “modified nano-precipitation” method. TEM, AFM, and DLS were used for character evaluation. HPLC and dialysis bags were also used to evaluate the amount of drug release and drug encapsulation. The MCF-7, MDA-MB231, and fibroblast cell lines were treated with different concentrations of the synthesized nano-carriers loaded DTX and free DTX over 48 and 72 hours. The MTT assay was used for investigating cytotoxic effects. The Annexin-V/PI staining and Hoechst-33342 staining were performed for apoptosis assay. The characterization techniques showed the designed nano-carrier has suitable properties for carrying drugs. The percentages of encapsulation, drug loading, and drug releasing were obtained by the HPLC technique. The MTT-assay results showed that inhibition of MCF-7 and MDA-MB231 cell growth and proliferation by P1 during 72 hours is significantly higher than 48 hours. The apoptosis assays showed the cytotoxic effects of synthesized nano-carriers that cause apoptosis cell death.
Conclusion
The results showed that DTX is effectively encapsulated by PCL-PEG-PCL nano-carriers, which can increase the solubility and bioavailability of the drug by high penetration into the cell. The nano-carrier P1 significantly caused early apoptosis of MCF-7, and MDA-MB231 cells. Accordingly, the IC50 of P1 on MCF-7 and MDA-MB231 cells in 72 hours was reported higher than at 48 hours. Based on the results obtained, it can be concluded that controlled drug release from the designed nano-carriers has been achieved and induction of apoptotic cell death has occurred.
Establishment of Novel Pulmonary Adenocarcinoma Cell Lines with Epithelial and Mesenchymal Morphology from a Dog
Authors: Kobayashi Kosuke , Takemura Reika Deja , Miyamae Jiro , Mitsui Ikki , Murakami Kohei , Kutara Kenji , Saeki Kohei , Kanda Teppei , Okamura Yasuhiko , Sugiyama Akihiko 
Published: July 2023

Abstract

Canine pulmonary adenocarcinoma (PAC) resembles human lung tumors in never-smokers, but it is rarer than human pulmonary adenocarcinoma. Therefore, research on canine PAC is challenging. In the present study, we successfully established various novel canine PAC cell lines from a single lesion in a dog, including two parent cell lines and fourteen cloned cell lines, and characterized their cellular propertiesin vitro. Several of these cell lines showed epithelial–mesenchymal transition (EMT)-like and/or cancer stem cell (CSCs)-like phenotypes. We additionally assessed the sensitivity of the cells to vinorelbinein vitro. Three clonal lines, two of which showed EMT- and CSC-like phenotypes, were resistant to vinorelbine. These novel canine PAC cell lines can be utilized in future research for understanding the pathogenesis and development of treatments for canine PAC.