bluuebunny/crossref_metadata_2025_split huggingface dataset:
Research on comprehensive detection and visualize of hidden cavity goaf
Authors: Cao Bo , Wang Jian , Du Han , Tao Yabin , Liu Guangwei 
Published: December 2022

AbstractAt present, the research on goaf at home and abroad mainly focuses on four aspects: detection technology, stability evaluation technology, governance technology and quality control technology. The most important of the above four aspects is goaf detection technology. In order to ensure the accuracy and precision of exploration, many geophysical methods and high-density geological drilling are usually used for exploration. In case of complex terrain, this method will increase the workload rapidly, and can not achieve a good balance between exploration cost and exploration quality. Goaf exploration methods are still in the development stage, and each geophysical exploration method has its limitations. This study makes full use of the existing detection technology to detect the complex mined-out area of East Open-pit Mine, 9 inferred mined-out areas and 9 suspected mined-out areas were found by using 3D seismic exploration method, transient electromagnetic method is used to delineate 223 abnormal areas at different elevations within the exploration range. 58 drilling holes are arranged in the suspected mined-out area of East Open-pit Mine. Combined with geological software, 3D model map of mined-out area is drawn, and the causes of formation of mined-out area are classified and analyzed. Using 3D laser scanning technology to study the visualization of hidden mined-out areas, the hidden mined-out areas are divided into three types through visualization research, and its formation mechanism is analyzed. It can be applied to detection of open-pit mines which have small underground coal mines and many mined-out areas with complex geometric shapes and has great significance to the proposal of stability treatment scheme of mined-out area. The novelty of this study is prove the area, shape, roof thickness and height of the mined-out area by using joint detection method and the hidden mined-out area is visualized by 3D laser scanning technology.
The immunolocalization of cluster of differentiation 31, phalloidin and alpha smooth muscle actin on vascular network of normal and ischemic rat brain
Authors: Wang Jia , Guo Yating , Xu Dongsheng , Cui Jingjing , Wang Yuqing , Su Yuxin , Liu Yihan , Shen Yi , Jing Xianghong , Bai Wanzhu 
Published: December 2022

AbstractCluster of differentiation 31 (CD31), phalloidin and alpha smooth muscle actin (α-SMA) have been widely applied to label the cerebral blood vessels in the past years. Although CD31 is mainly used as endothelial marker in determining the cerebral capillaries, it seems likely that its labeling efficiency is closely correlated with the antibodies from the polyclonal or monoclonal one, as well as the conditions of blood vessels. In order to test this phenomenon, we compared the labeling characteristics of goat polyclonal anti-CD31 (gP-CD31) and mouse monoclonal anti-CD31 (mM-CD31) with those of phalloidin and α-SMA on the rat brain in health and ischemia/reperfusion (I/R) with the middle cerebral artery occlusion. By multiple immunofluorescence staining, it was found that gP-CD31 labeling expressed extensively on the cerebral capillaries forming the vascular networks on the normal and ischemic regions, but mM-CD31 labeling mainly presented on the capillaries in the ischemic region. In contrast to the vascular labeling with gP-CD31, phalloidin and α-SMA were mainly expressed on the wall of cortical penetrating arteries, and less on that of capillaries. By three-dimensional reconstruction analysis, it was clearly shown that gP-CD31 labeling was mainly located on the lumen side of vascular wall and was surrounded by phalloidin labeling and α-SMA labeling. These results indicate that gP-CD31 is more sensitive than mM-CD31 for labeling the cerebral vasculature, and is highly compatible with phalloidin and α-SMA for evaluating the cerebral vascular networks under the physiological and pathological conditions.
Pseudomonas aeruginosa PAO1 outer membrane vesicles-diphtheria toxoid conjugate as a vaccine candidate in a murine burn model
Authors: Zare Banadkoki Ehsan , Rasooli Iraj , Ghazanfari Tooba , Siadat Seyed Davar , Shafiee Ardestani Mehdi , Owlia Parviz 
Published: December 2022

AbstractPseudomonas aeruginosa is an opportunistic pathogen considered a common cause of nosocomial infection with high morbidity and mortality in burn patients. Immunoprophylaxis techniques may lower the mortality rate of patients with burn wounds infected by P. aeruginosa; consequently, this may be an efficient strategy to manage infections caused by this bacterium. Several pathogenic Gram-negative bacteria like P. aeruginosa release outer membrane vesicles (OMVs), and structurally OMV consists of several antigenic components capable of generating a wide range of immune responses. Here, we evaluated the immunogenicity and efficacy of P. aeruginosa PA-OMVs (PA-OMVs) conjugated with the diphtheria toxoid (DT) formulated with alum adjuvant (PA-OMVs-DT + adj) in a mice model of burn wound infection. ELISA results showed that in the group of mice immunized with PA-OMVs-DT + adj conjugated, there was a significant increase in specific antibodies titer compared to non-conjugated PA-OMVs or control groups. In addition, the vaccination of mice with PA-OMVs-DT + adj conjugated generated greater protective effectiveness, as seen by lower bacterial loads, and eightfold decreased inflammatory cell infiltration with less tissue damage in the mice burn model compared to the control group. The opsonophagocytic killing results confirmed that humoral immune response might be critical for PA-OMVs mediated protection. These findings suggest that PA-OMV-DT conjugated might be used as a new vaccine against P. aeruginosa in burn wound infection.
Arf1 facilitates mast cell proliferation via the mTORC1 pathway
Authors: Kotani Yui , Sumiyoshi Mami , Sasada Megumi , Watanabe Toshio , Matsuda Satoshi 
Published: December 2022

AbstractMast cells are one of major players in allergic responses. Mast cell activation via the high affinity IgE receptor (FcεRI) causes degranulation and release of de novo synthesized proinflammatory cytokines in a process that involves vesicle trafficking. Considering that the GTPase ADP-ribosylation factor 1 (Arf1) orchestrates and maintains membrane traffic and organelle structure, it seems likely that Arf1 contributes to mast cell activation. Actually, it has been reported that pharmaceutical blockade of the Arf1 pathway suppresses cytokine secretion and mast cell degranulation. However, physiological roles of Arf1 in mast cells remain elusive. Here, by using a genetic approach, we demonstrate that Arf1 is required for optimal mTORC1 activation upon IL-3 and facilitates mast cell proliferation. On the other hand, contrary to our expectation, Arf1-deficiency had little impact on FcεRI-induced degranulation nor cytokine secretion. Our findings reveal an unexpected role of Arf1 in mast cell expansion and its potential as a therapeutic target in the mast cell proliferative disorders.
Surface engineering of zinc phthalocyanine organic thin-film transistors results in part-per-billion sensitivity towards cannabinoid vapor
Authors: Comeau Zachary J. , Cranston Rosemary R. , Lamontagne Halynne R. , Harris Cory S. , Shuhendler Adam J. , Lessard Benoît H. 
Published: December 2022

AbstractPhthalocyanine-based organic thin-film transistors (OTFTs) have been demonstrated as sensors for a range of analytes, including cannabinoids, in both liquid and gas phases. Detection of the primary cannabinoids, Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD), is necessary for quality control and regulation, however, current techniques are often not readily available for consumers, industry, and law-enforcement. The OTFT characteristics, X-ray diffraction (XRD) spectra, and grazing incident wide angle x-ray scattering (GIWAXS) spectra of two copper and three zinc phthalocyanines, with varying degrees of peripheral fluorination, were screened to determine sensitivity to THC vapor. Unsubstituted ZnPc was found to be the most sensitive material and, by tuning thin-film morphology, crystal polymorphs, and thickness through altered physical vapor deposition conditions, we increased the sensitivity to THC by 100x. Here we demonstrate that deposition conditions, and the resulting physical film characteristics, play a significant role in device sensitization.
Authigenic clays as precursors to carbonate precipitation in saline lakes of Salar de Llamara, Northern Chile
Authors: Suosaari Erica P. , Lascu Ioan , Oehlert Amanda M. , Parlanti Paola , Mugnaioli Enrico , Gemmi Mauro , Machabee Paul F. , Piggot Alan M. , Palma Alvaro T. , Reid R. Pamela 
Published: December 2022

AbstractThe Salar de Llamara, Atacama Desert is host to saline lakes known as Puquios, which are possible analogs for lakes on early Earth or Mars. Here we examine associations between microbial communities, Mg-clay minerals, and carbonates in microbial mat samples from the Puquios using scanning electron microscopy, energy dispersive X-ray spectroscopy, focused ion beam nanotomography, and transmission electron microscopy. We observe micrometer-scale aggregates of nanocrystalline Mg-clay around cyanobacterial cell sheaths and throughout alveolar networks of microbial extracellular polymeric substances. High-Mn calcite occupies pore spaces and surfaces within the clay matrix. We propose a sequence whereby extracellular polymeric substance networks serve as surfaces for precipitation of Mg-clay, which permineralizes the original microorganisms. Formation of the clay reduces kinetic barriers and provides a suitable substrate for the formation of carbonate minerals. We therefore suggest that authigenic clays are important in the preservation of microbial communities and the precipitation of carbonates in non-marine settings such as the saline lakes of the Atacama Desert.
Changes in the membrane lipid composition of a Sulfurimonas species depend on the electron acceptor used for sulfur oxidation
Authors: Ding Su , Henkel Jan V , Hopmans Ellen C , Bale Nicole J , Koenen Michel , Villanueva Laura , Damsté Jaap S Sinninghe 
Published: December 2022

Abstract
Sulfurimonas species are among the most abundant sulfur-oxidizing bacteria in the marine environment. They are capable of using different electron acceptors, this metabolic flexibility is favorable for their niche adaptation in redoxclines. When oxygen is depleted, most Sulfurimonas spp. (e.g., Sulfurimonas gotlandica) use nitrate ( NO3−) as an electron acceptor to oxidize sulfur, including sulfide (HS−), S0 and thiosulfate, for energy production. Candidatus Sulfurimonas marisnigri SoZ1 and Candidatus Sulfurimonas baltica GD2, recently isolated from the redoxclines of the Black Sea and Baltic Sea respectively, have been shown to use manganese dioxide (MnO2) rather than NO3− for sulfur oxidation. The use of different electron acceptors is also dependent on differences in the electron transport chains embedded in the cellular membrane, therefore changes in the membrane, including its lipid composition, are expected but are so far unexplored. Here, we used untargeted lipidomic analysis to reveal changes in the composition of the lipidomes of three representative Sulfurimonas species grown using either NO3− and MnO2. We found that all Sulfurimonas spp. produce a series of novel phosphatidyldiazoalkyl-diacylglycerol lipids. Ca. Sulfurimonas baltica GD2 adapts its membrane lipid composition depending on the electron acceptors it utilizes for growth and survival. When carrying out MnO2-dependent sulfur oxidation, the novel phosphatidyldiazoalkyl-diacylglycerol headgroup comprises shorter alkyl moieties than when sulfur oxidation is NO3−-dependent. This is the first report of membrane lipid adaptation when an organism is grown with different electron acceptors. We suggest novel diazoalkyl lipids have the potential to be used as a biomarker for different conditions in redox-stratified systems.
Retracted: Self‐attention Bi‐RNN for developer emotion recognition based on EEG
Authors: Wang Yingdong , Zheng Yuhui , Cao Lu , Zhang Zhiling , Ruan Qunsehng , Wu Qingfeng 
Published: December 2022

AbstractRetraction: [Yingdong Wang, Yuhui Zheng, Lu Cao, Zhiling Zhang, Qunsehng Ruan, Qingfeng Wu, Self‐attention Bi‐RNN for developer emotion recognition based on EEG, IET Software 2022 (https://doi.org/10.1049/sfw2.12080)].The above article from IET Software, published online on 23 December 2022 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the Editor‐in‐Chief, Hana Chockler, the Institution of Engineering and Technology (the IET) and John Wiley and Sons Ltd. This article was published as part of a Guest Edited special issue. Following an investigation, the IET and the journal have determined that the article was not reviewed in line with the journal’s peer review standards and there is evidence that the peer review process of the special issue underwent systematic manipulation. Accordingly, we cannot vouch for the integrity or reliability of the content. As such we have taken the decision to retract the article. The authors have been informed of the decision to retract.
A systematic mapping study on machine learning methodologies for requirements management
Authors: Xu Chi , Li Yuanbang , Wang Bangchao , Dong Shi 
Published: December 2022

AbstractRequirements management (RM) plays an important role in requirements engineering. The development of machine learning (ML) is in full swing, and many ML software management techniques had been used to improve the performance of RM methods. However, as no research study is known that exists systematically to summarise the ML methods used in RM. To fill this gap, this paper adopts the systematic mapping study to survey the state‐of‐the‐art ML methods for RM primary studies and were finally selected in this mapping, which was published on 36 conferences and journals. The 24 factors affecting the ML method of RM are determined, of which 9, 11 and 4 are the three parts of RM, namely requirements baseline maintenance, requirements traceability and requirements change management separately. The 18 objectives of the ML method for RM are summarised, of which 6, 7 and 5 are the three parts of RM. The eight ML methods used in RM and their time sequence are summarised. The 18 evaluation indexes for RM in the ML method are determined, and the performance of these methods on these parameters is analysed. The research direction of this paper is of great significance to the research of researchers in demand management.
Biological Activity of a 4-Hydroxy-Furanyl-Benzamide Derivative on Heart Failure
Authors: Lauro Figueroa-Valverde , Marcela Rosas-Nexticapa , Maria López-Ramos , Magdalena Alvarez-Ramirez , Virginia Mateu-Armad Maria , Francisco Díaz-Cedillo , Catalina Cervantes-Ortega , Montserrat Melgarejo-Guutierrez 
Published: December 2022

AbstractBackground There are studies that suggest that some benzamide derivatives may exert effects on heart failure; however, their molecular mechanism is not very clear.Objective The aim of this research was to evaluate the biological activity of a 4-hydroxy-furanyl-benzamide derivative against heart failure translated as area infarct.Methods Biological activity produced by 4-hydroxy-furanyl-benzamide derivative against heart failure was determinate using an ischemia-reperfusion injury model. In addition, the effects exerted by the 4-hydroxy-furanyl-benzamide derivative on left ventricular pressure (LVP) was evaluated in the absence or presence of some drugs such as yohimbine, butaxamine, methoctramine and L-NAME using a model of rat heart isolated.Results The results showed that 4-hydroxy-furanyl-benzamide derivative decrease both infarct area and LVP. However, the effect produced by 4-hydroxy-furanyl-benzamide derivative on LVP was inhibited in the presence of both methoctramine and L-NAME.Conclusions All these data suggest that biological activity produced by 4-hydroxy-furanyl-benzamide derivative on left ventricular pressure is through of both M2-muscarinic receptor and nitric oxide synthase enzyme activation. It is important to mention that this phenomenon results as a decrease of both infarct area and heart failure.
Bilaterale Oberlidschwellung mit Abszedierung unter Etanercept-Therapie
Authors: Bartmann Iva Ruth , Alnawaiseh Maged , Mihailovic Natasa 
Published: December 2022

ZusammenfassungWir präsentieren den Fall einer 66-jährigen Patientin, bei der sich unter Etanercept-Therapie bei rheumatoider Arthritis eine bilaterale Oberlidschwellung mit Abszedierung zeigte. Da das
simultane und bilaterale Auftreten von Oberlidabszessen mit systemischer Ursache sehr selten ist und sich in der Literatur Fälle einer Abszedierung unter Etanercept-Therapie finden,
diskutieren wir eine mögliche Verbindung zwischen der bilateralen Oberlidabszedierung und der bestehenden immunsuppressiven Therapie.
The Relationship between Ergometric Treadmill or Bicycle
Performance and Isokinetic Trunk Strength – A Retrospective
Analysis
Authors: Geißler Daniel , Lison Andreas , Schulze Christoph 
Published: December 2022

AbstractThe relationship between trunk strength and athletic performance is well known.
In the past, trunk strength and athletic performance were measured in field
tests. Previous studies encouraged sport-specific analyses. The goal of this
study was to investigate whether there is a relation between ergometrically
measured treadmill or bicycle endurance and isokinetic trunk strength. This
retrospective analysis included 1334 bicycle and 1838 treadmill ergometry
examinations in 1149 subjects. Bicycle and treadmill ergometer performance were
analysed in relation to isokinetic trunk strength. Statistics were performed by
Pearson correlation and mixed or generalised linear models. Higher treadmill and
bicycle power correlated with higher isokinetic trunk strength, with highest
absolute trunk strength in the treadmill group. For both running and cycling
endurance, a positive correlation with trunk strength could be quantified in
regression models. Increased ergometry endurance and lower
flexion/extension ratios are connected weakly. Ergometry performance had
the strongest correlation with extension trunk strength
(r=0.312–0.398 for bicycle ergometry and
r=0.168–0.229 for treadmill ergometry, p<0.001). We
encourage prospective studies using both kinds of ergometry to evaluate the
effect of trunk strengthening to enhance sport-specific endurance performance.
Weight-adapted trunk strength values showed overall greater correlation to trunk
strength and we recommend the use of weight-adapted values.
Neuroendokrine Tumoren im Kopf-, Halsbereich
Authors: Duong Dinh Thien An , Braunschweig Till , Ilgner Justus , Westhofen Martin 
Published: December 2022

Zusammenfassung
Hintergrund Neuroendokrine Tumoren (NET) sind benigne oder maligne Neoplasien, die entwicklungsgeschichtlich der Neuralleiste oder paraganglionären Zellen des vegetativen Nervensystems entstammen. Die alte Bezeichnung Karzinoid (karzinomähnlicher Tumor) ist noch sehr verbreitet, jedoch inzwischen obsolet. Lediglich 0,5–2 % aller Neoplasien des Menschen sind neuroendokrine Tumoren, welche überwiegend gastrointestinal oder bronchopulmonal lokalisiert sind. Die Inzidenz beträgt 9.263/100.000. Jedoch ist nur 1 % der Kopf-Hals-Tumore neuroendokriner Genese. Fallzahlstarke Langzeitstudien und Leitlinien zur Diagnose und Therapie im Kopf-Hals-Bereich fehlen. Ziel dieser Arbeit ist der wertende Vergleich bekannter Therapiestrategien und daraus folgender Krankheitsverläufe sowie deren Vergleich mit dem Schrifttum anhand eigener Fälle unterschiedlicher Lokalisation und Ausdehnung.
Patienten und Methoden In unserer Klinik wurden zwischen 2010 und 2017 14 Patienten mit neuroendokrinen Tumoren im Kopf-Hals-Bereich behandelt. Acht Patienten davon wurden primär operativ mit adjuvanter Radiochemotherapie (RCT) versorgt. Sechs Patienten erhielten eine primäre Radiochemotherapie in kurativer Absicht. Ein Patient erhielt aufgrund des Tumorprogresses nach der primären Radiochemotherapie eine weitere Chemotherapie mit palliativer Indikation.
Ergebnisse Die Tumorlokalisationen verteilen sich auf den Larynx (n = 7), die Glandula parotis (n = 2) und auf die Nasenhaupt- und -nebenhöhlen (n=5). Von den 8 operierten Patienten konnte in 6 Fällen eine in-sano-Resektion (R0) erreicht werden. Die im Kollektiv gemessene Gesamtüberlebensrate beträgt im Mittel 19±6 Monate. Von den 14 untersuchten Patienten erlitten 2 Patienten ein Rezidiv, wovon ein Patient nach 7 Monaten verstarb und ein Patient 32 Monate nach der Nachresektion Rezidiv-frei lebt. In zwei Fällen sprach das NET nicht auf die kombinierte RCT an und die Patienten verstarben jeweils nach 6 und 13 Monaten. Die Überlebenszeit ist abhängig vom T-Stadium des NET sowie vom Erreichen einer R0-Resektion. Die R0-Resektion bietet eine höhere Überlebenswahrscheinlichkeit als die primäre RCT.
Schlussfolgerung Patienten mit NET des Kopf-Hals-Bereiches müssen in spezialisierten Zentren interdisziplinär behandelt werden. Zur Erfassung dieser Daten ist eine Tumordatenbank notwendig. Jedoch sind aufgrund der niedrigen Inzidenz keine Studien auf hohem Evidenzniveau zu erwarten. Nach Diagnosestellung sollte ohne zeitliche Verzögerung die im Rahmen einer int. TuKo individuelle auf den Patienten zugeschnittene Therapie erfolgen.
Leitlinienbasierte digitale Tabakentwöhnung mit PC, Tablet oder Smartphone
Authors: Rupp Alexander , Hering Thomas , Bubeck Alena , Kreuter Michael 
Published: December 2022

Zusammenfassung
Einführung Inhalatives Rauchen ist mit erheblicher Morbidität und Mortalität sowie einer signifikanten Belastung der Gesundheitsökonomie verbunden. Der möglichst frühe Rauchstopp ist daher medizinisch und gesundheitsökonomisch von herausragender Bedeutung. Mit dem aktuellen Goldstandard der Tabakentwöhnung, einer kombinierten verhaltenstherapeutischen und medikamentösen Unterstützung, werden bevölkerungsbezogen nur unzureichend viele Raucher erreicht. Leitlinienkonforme, niederschwellige und breit verfügbare digitale Entwöhnungsangebote könnten dagegen die Zahl erfolgreicher Aufhörer signifikant steigern. Mit dem digitalen Entwöhnungsprogramm „Nichtraucherhelden“ (Online-Version und Smartphone-App) steht seit 2016 eine solche leitlinienkonforme und niederschwellige digitale Tabakentwöhnung zur Verfügung. Das Programm besteht aus 2 Vorbereitungs- und 10 Programmtagen und umfasst die Kerninhalte gängiger Tabakentwöhnungskurse.
Probanden und Methodik Die vorliegende Studie untersuchte die Programmteilnehmer im Zeitraum von Dez. 2016 bis Nov. 2019 (n = 2491) retrospektiv in Bezug auf Akzeptanz, Adhärenz und Effektivität. 69 % der TN waren weiblich, das Durchschnittsalter betrug 46 Jahre.
Ergebnisse Der Rauchstopptag wurde im Durchschnitt nach knapp 19 Tagen erreicht. Die Aufhörquote nach einem Jahr lag bei 15 %. Unerwartet war die höhere Aufhörquote stärker abhängiger Raucher im Vergleich zu weniger stark Abhängigen.
Folgerung Die Untersuchung zeigt die prinzipielle Durchführbarkeit und Wirksamkeit eines digitalen, leitlinienkonformen Entwöhnungsprogramms. Zur Bestätigung der Effektivität ist eine randomisierte, kontrollierte Studie erforderlich.