bluuebunny/crossref_metadata_2025_split huggingface dataset:
Is hybrid therapy more efficient in the eradication of Helicobacter pylori infection? A systematic review and meta-analysis
Authors: Temido Maria José , Mbanze Dara , Almeida Nuno , Oliveiros Bárbara , Gravito-Soares Elisa , Figueiredo Pedro 
Published: July 2023

Abstract
Introduction
Hybrid therapy (HT) is a non-bismuth quadruple therapy created to surpass Helicobacter pylori’s (H. pylori) resistance rates to antibiotics. HT has excellent eradication rates, as well as a very good compliance and safety profile. We aim to compare HT with sequential therapy (ST) and concomitant therapy (CT) for the eradication of H. pylori.

Methods
This systematic review was conducted following the principles of the PRISMA guidelines. Literature was electronically searched on the CENTRAL library, PubMed, Embase, Scopus, LILACS, and ClinicalTrials.gov. Only randomized controlled trials were included. The primary outcome evaluated was eradication rate of H. pylori. The secondary outcomes evaluated were adverse events and compliance rates. Meta-analyses were performed with Cochrane Review Manager 5.4. The Mantel–Haenszel method was used to estimate the pooled relative risk and 95% confidence interval of the eradication rates between HT and other regimens, as well as the secondary outcomes.

Results
10 studies were included, comprising 2993 patients. The mean eradication rates achieved by HT with intention-to-treat (ITT) and per-protocol (PP) analyses were, respectively, 86% (range: 79.2–90.8%) and 91.7% (range: 82.6–96.1%). No statistically significant difference was found in ITT eradication rate between HT and CT (relative risk: 1; 95% CI: 0.96- 1.03) and between HT and ST (relative risk: 1.02; 95% CI: 0.92–1.14). PP analysis revealed similar results. HT was associated with higher compliance rates than CT and slightly lower than ST. As far as adverse events are concerned, this meta-analysis demonstrated a higher occurrence of adverse events on the group of patients treated with CT when compared with HT. HT and ST showed similar results.

Conclusion
HT has similar eradication, compliance and adverse event rates when compared to ST, but a better safety profile than the CT.
Oral membrane-biomimetic nanoparticles for enhanced endocytosis and regulation of tumor-associated macrophage
Authors: Gu Xiaoyan , Zhang Rongguang , Sun Yingwei , Ai Xinyi , Wang Yu , Lyu Yaqi , Wang Xiaoyu , Wu Yihan , Wang Zhi , Feng Nianping , Liu Ying 
Published: July 2023

AbstractEnterocyte uptake with high binding efficiency and minor endogenous interference remains a challenge in oral nanocarrier delivery. Enterocyte membrane-biomimetic lipids may universally cooperate with endogenous phosphatidyl choline via a biorthogonal group. In this study, we developed a sophorolipid-associated membrane-biomimetic choline phosphate-poly(lactic-co-glycolic) acid hybrid nanoparticle (SDPN). Aided by physical stability in the gastrointestinal tract and rapid mucus diffusion provided by association with sophorolipid, these nanoparticles show improved endocytosis, driven by dipalmitoyl choline phosphate-phosphatidyl choline interaction as well as its optimized membrane fluidity and rigidity. Luteolin- and silibinin-co-loaded with SDPN alleviated breast cancer metastasis in 4T1 tumor-bearing mice by regulating the conversion of tumor-associated M2 macrophages into the M1 phenotype and reducing the proportion of the M2-phenotype through co-action on STAT3 and HIF-1α. In addition, SDPN reduces angiogenesis and regulates the matrix barrier in the tumor microenvironment. In conclusion, this membrane-biomimetic strategy is promising for improving the enterocyte uptake of oral SDPN and shows potential to alleviate breast cancer metastasis.
Dieulafoy’s disease of the bronchus: rare but potentially fatal: a case report and a review of literature
Authors: Daboussi Salsabil , kacem Marwa , Boubaker Nouha , Chaabene Mariem , Aichaouia Chiraz , Mhamdi Samira , Moatemri Zied 
Published: July 2023

Abstract
Background
Dieulafoy’s disease of the bronchus can cause massive and even fatal hemoptysis. Even though it is rare, it should be considered by physicians all over the world. This paper reports a case of bronchial Dieulafoy’s disease and summarizes the data of similar cases reported in literature.

Methods
We report a case of bronchial Dieulafoy’s disease (BDD) in Tunisia. We also present a review of literature related to BDD from 1995 to 2022 using the PubMed, Google Scholar, web of science and Chinese National Knowledge Infrastructure Databases. Clinical characteristics, chest imaging, bronchoscopic and angiographic findings were summarized. Treatment courses were identified as well as patients’ outcome.

Results
We report the case of a 41-year-old man, so far in good health, presenting with massive hemoptysis. Bronchoscopy showed blood clots and a protruding lesion covered by mucosa with a white pointed cap at the entrance of the right upper lobe. Biopsies were not attempted. Embolization of bronchial artery was first realized and was not successful, with post procedure complications. Surgical intervention stopped the bleeding and pathological examination of the resected specimen confirmed Dieulafoy’s disease of the bronchus. Ninety cases of BDD were reported from 1995 to 2022. The main symptom was hemoptysis. Chest imaging findings were not specific. The diagnosis of BDD was mainly based on the bronchoscopy, branchial angiography and pathological findings or surgical specimens. Bronchoscopy findings were mostly nodular or prominent lesions (52.4%). Twenty-eight patients underwent bronchoscopic biopsies, 20 had massive bleeding and 10 died. Bronchial angiography mainly showed tortuous and dilation of bronchial artery, and the lesions were mainly located in the right bronchus. Selective bronchial artery embolization (SBAE) was performed in 32 patients and 39 patients underwent surgery.

Conclusion
To our knowledge, this is the first case of bronchial Dieulafoy’s disease to be reported in Tunisia and North Africa. When the diagnosis is suspected, bronchoscopic biopsy should be avoided as it might lead to fatal hemorrhage. Selective bronchial artery embolization can stop the bleeding, but surgery can be required.
Biosynthesis pathways of expanding carbon chains for producing advanced biofuels
Authors: Su Haifeng , Lin JiaFu 
Published: July 2023

AbstractBecause the thermodynamic property is closer to gasoline, advanced biofuels (C ≥ 6) are appealing for replacing non-renewable fossil fuels using biosynthesis method that has presented a promising approach. Synthesizing advanced biofuels (C ≥ 6), in general, requires the expansion of carbon chains from three carbon atoms to more than six carbon atoms. Despite some specific biosynthesis pathways that have been developed in recent years, adequate summary is still lacking on how to obtain an effective metabolic pathway. Review of biosynthesis pathways for expanding carbon chains will be conducive to selecting, optimizing and discovering novel synthetic route to obtain new advanced biofuels. Herein, we first highlighted challenges on expanding carbon chains, followed by presentation of two biosynthesis strategies and review of three different types of biosynthesis pathways of carbon chain expansion for synthesizing advanced biofuels. Finally, we provided an outlook for the introduction of gene-editing technology in the development of new biosynthesis pathways of carbon chain expansion.
Implementation strategies to scale up self-administered depot medroxyprogesterone acetate subcutaneous injectable contraception: a scoping review
Authors: Aderoba Adeniyi Kolade , Steyn Petrus Schoken , Kiarie James Njogu 
Published: July 2023

Abstract
Background
Self-administered depot medroxyprogesterone acetate subcutaneous injectable contraception (DMPA-SC) is registered in many countries. It shows great potential for improving contraceptive access, continuation, and autonomy. However, there are challenges in rolling out this new efficacious intervention, and major implementation problems have been encountered during scale-up.

Objective
To describe the implementation strategies to scale up self-administered DMPA-SC and the barriers, facilitators, and outcomes of these programs.

Method
Recent guidelines, including the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) extension for scoping reviews, were used to design and report this review. An article or report was eligible for inclusion if it reported interventions that could scale up self-administered DMPA-SC implementation or its facilitators, barriers, or outcomes. We searched six electronic databases and the grey literature for eligible articles and reports. Two reviewers independently screened the document titles, abstracts, and full texts to identify eligible documents. Data were extracted using structured forms. Using the Effective Practice and Organization of Care (EPOC) taxonomy of health systems framework for thematic analysis, data were presented in a narrative approach.

Results
Of the 755 retrieved documents, 34 were included in this review. Most of the documents included were multi-country reports (n = 14), and all documents were published within the last 5 years (2018–2021). This review identified documents that reported interventions in all EPOC domains. The most-reported interventions were: task-sharing amongst health workforce cadres, engaged leadership, encouraging policies, training and education, DMPA-SC demand generation, integration into existing programs, improved funding mechanisms, collaboration with development partners, and supply chain strengthening. The main barriers were suboptimal funding, inadequate human resources, and poor logistics supply of DMPA-SC. There was minimal evidence of scale-up outcomes.

Conclusion
This scoping review reported a wide range of interventions employed by countries and programs to scale up DMPA-SC self-administration but minimal evidence of the scale-up outcomes. Evidence from this review can help design better programs that improves access to quality family planning services to achieve the Sustainable Development Goals (SDG) targets 3.7. However, efforts should focus on rigorous implementation research that assess scaled up self-administered DMPA-SC interventions and report their outcomes.

Registration
The protocol for this review was registered in the protocols.io repository (https://www.protocols.io/view/a-protocol-for-a-scoping-review-of-implementation-x54v9yemmg3e/v1).
Application of artificial intelligence for forecasting surface quality index of irrigation systems in the Red River Delta, Vietnam
Authors: Nguyen Duc Phong , Ha Hai Duong , Trinh Ngoc Thang , Nguyen Minh Tu 
Published: July 2023

AbstractWater sources for irrigation systems in the Red River Delta are crucial to the socioeconomic growth of the region's communities. Human activities (discharge) have polluted the water source in recent years, and the water source from upstream is limited. Currently, the surface water quality index (WQI), which is calculated from numerous surface water quality parameters (physical, chemical, microbiological, heavy metals, etc.) is frequently used to evaluate the surface water quality of irrigation systems. However, the calculation of the WQI from water quality monitoring parameters remains constrained due to the need for a large number of monitoring parameters and the relative complexity of the calculation. To better serve the assessment of surface water quality in the study area, it is crucial and essential to conduct research to identify an efficient and accurate method of calculating the WQI. This study used machine learning and deep learning algorithms to calculate the WQI with minimal input data (water quality parameters) to reduce the cost of monitoring surface water quality. The study used the Bayes method (BMA) to select important parameters (BOD5, NH4+, PO43−, turbidity, TSS, coliform, and DO). The results indicate that the machine learning model is more effective than the deep learning model, with the gradient boosting model having the most accurate prediction results because it has the highest coefficient of determination R2 (0.96). This is a solid scientific basis and an important result for the application of machine learning and deep learning algorithms to calculate WQI for the research area. The study also demonstrated the potential of artificial intelligence algorithms to improve water quality forecasting compared to traditional methods with minimal cost and time.
Characteristics of glucose and lipid metabolism and the interaction between gut microbiota and colonic mucosal immunity in pigs during cold exposure
Authors: Teng Teng , Sun Guodong , Ding Hongwei , Song Xin , Bai Guangdong , Shi Baoming , Shang Tingting 
Published: July 2023

AbstractBackgroundCold regions have long autumn and winter seasons and low ambient temperatures. When pigs are unable to adjust to the cold, oxidative damage and inflammation may develop. However, the differences between cold and non-cold adaptation regarding glucose and lipid metabolism, gut microbiota and colonic mucosal immunological features in pigs are unknown. This study revealed the glucose and lipid metabolic responses and the dual role of gut microbiota in pigs during cold and non-cold adaptation. Moreover, the regulatory effects of dietary glucose supplements on glucose and lipid metabolism and the colonic mucosal barrier were evaluated in cold-exposed pigs.ResultsCold and non-cold-adapted models were established by Min and Yorkshire pigs. Our results exhibited that cold exposure induced glucose overconsumption in non-cold-adapted pig models (Yorkshire pigs), decreasing plasma glucose concentrations. In this case, cold exposure enhanced the ATGL and CPT-1α expression to promote liver lipolysis and fatty acid oxidation. Meanwhile, the two probiotics (CollinsellaandBifidobacterium) depletion and the enrichment of two pathogens (SutterellaandEscherichia-Shigella) in colonic microbiota are not conducive to colonic mucosal immunity. However, glucagon-mediated hepatic glycogenolysis in cold-adapted pig models (Min pigs) maintained the stability of glucose homeostasis during cold exposure. It contributed to the gut microbiota (including the enrichment of theRikenellaceae RC9 gut group,[Eubacterium] coprostanoligenes groupandWCHB1-41) that favored cold-adapted metabolism.ConclusionsThe results of both models indicate that the gut microbiota during cold adaptation contributes to the protection of the colonic mucosa. During non-cold adaptation, cold-induced glucose overconsumption promotes thermogenesis through lipolysis, but interferes with the gut microbiome and colonic mucosal immunity. Furthermore, glucagon-mediated hepatic glycogenolysis contributes to glucose homeostasis during cold exposure.
Comparative study on epidemiological and etiological characteristics of patients with acute diarrhea with febrile or non-febrile symptoms in China
Authors: Wang Tao , Wang Gang , Shan Chun-Xi , Sun Yan-Qun , Ren Xiang , Yu Lin-Jie , Wang Yi-Fei , Lin Sheng-Hong , Zhang Xiao-Ai , Li Hao , Zhang Cui-Hong , Geng Meng-Jie , Yang Wei-Zhong , Wang Li-Ping , Liu Wei , Fang Li-Qun 
Published: July 2023

AbstractBackgroundAcute diarrhea with fever can potentially represent a more severe form of the disease compared to non-febrile diarrhea. This study was to investigate the epidemiological characteristics and enteric pathogen composition of febrile-diarrheal patients, and to explore factors including pathogens associated with fever by age group.MethodsA nationwide surveillance study of acute diarrheal patients of all ages was conducted in 217 sentinel hospitals from 31 provinces (autonomous regions or municipalities) in China between 2011 and 2020. Seventeen diarrhea-related pathogens, including seven viruses and ten bacteria, were investigated and their association with occurrence of fever symptoms was assessed using multivariate logistic analysis.ResultsA total of 146,296 patients with acute diarrhea (18.6% with fever) were tested. Th diarrheal children below 5 years had the highest frequency of fever (24.2%), and related to significantly higher prevalence of viral enteropathogens (40.2%) as compared with other age groups (P < 0.001). Within each age group, the febrile-diarrheal patients were associated with a significantly higher prevalence of bacterial pathogens than afebrile-diarrheal patients (allP < 0.01). There was discrepancy when each pathogen was compared, i.e., nontyphoidalSalmonella(NTS) was overrepresented in febrile vs non-febrile patients of all age groups, while the febrile vs non-febrile difference for diarrheagenicEscherichia coli(DEC) was only significant for adult groups. The multivariate analysis revealed significant association between fever and infection with rotavirus A among children [odds ratio (OR) = 1.60], for DEC in adult groups (OR = 1.64), for NTS in both children (OR = 2.95) and adults (OR = 3.59).ConclusionsThere are significant discrepancy of the infected enteric pathogens in patients with acute diarrhea with fever between age groups, and it is valuable for priority detection of NTS and rotavirus A in patients with children < 5 years old and NTS and DEC in adult patients. The results may be useful in identifying dominant pathogen candidates for the application of diagnostic assays and prevention control.Graphical Abstract
Stigmatizing imagery for substance use disorders: a qualitative exploration
Authors: Hulsey Jessica , Zawislak Kayla , Sawyer-Morris Ginnie , Earnshaw Valerie 
Published: July 2023

Abstract
Background
Stigma is a significant barrier to the treatment of individuals with substance use disorders. While prior efforts have been made to change stigmatizing language to refer to individuals with substance use disorders (SUD), little is known about the effects of stigmatizing imagery. There is a need for complementary qualitative research to identify both stigmatizing and non-stigmatizing imagery in the field of SUD.

Methods
This study used qualitative methods to identify stigmatizing and non-stigmatizing imagery for SUD and explore the reactions of people with lived experience with SUD to SUD-related imagery. We conducted focus groups and brief semi-structured qualitative interviews with 14 individuals in recovery from a range of SUD.

Results
Participants identified images of substance use and criminal justice contact that are negative or stigmatizing, along with alternative images that were endorsed for use. The unanticipated concept of imagery-induced triggering and cue reactivity emerged in the interviews, along with an emphasis on diversity in race/ethnicity, gender, and age for representations of both patients and clinicians in all imagery.

Conclusions
The findings can be helpful in informing imagery that can depict addiction, individuals with SUD, and individuals involved in the justice system for various fields from research to media, public health, and community-based programming. Based on qualitative feedback from patients on triggering effects and reactivity to visual cues, it is never appropriate to use drug use and drug paraphernalia imagery to depict substance use or misuse or pictures of people in cages.
Assessing the feasibility, fidelity and acceptability of a behaviour change intervention to improve tractor safety on farms: protocol for the BeSafe tractor safety feasibility study
Authors: Surendran Aswathi , McSharry Jenny , Meredith David , McNamara John , Bligh Francis , Meade Oonagh , O’Hora Denis 
Published: July 2023

AbstractBackgroundIn Ireland, the agriculture sector reports the highest number of fatalities even though farmers constitute only 6% of the working population. Tractor-related behaviours are implicated in 55% of all vehicle work-related fatalities and 25% of reported injuries, and many of these occur in farmyards. There is limited research on the feasibility and acceptability of behaviour change interventions to improve tractor safety. Target behaviours that promote safe operation in farmyards, determining and addressing blind spots of tractors, were identified, and an intervention was developed following the Behaviour Change Wheel Approach. The objective of the study is to examine the feasibility, fidelity and acceptability of a behaviour change intervention to enhance the safe operation of tractors in farmyards with a particular focus on tractor blind spots.MethodA single group feasibility study will be undertaken. Approximately 16 farmers from four major farm types will be recruited for the study between August and September 2022. The intervention involves an in-person demo session, facilitated discussion and personalised safety training procedure with safety goals. The study will collect data from participants at three time points: baseline (3–10 days prior to the intervention), during the intervention and at the follow-up session (7–30 days post-intervention). Quantitative data will be collected through a pre-intervention interview and feedback surveys. A pre- and post-intervention qualitative interview will also be conducted with the participants and will be supplemented with qualitative data from recruitment logs, observational memos and logs and feedback from recruiters. Evaluation of the feasibility, acceptability and fidelity of the intervention will be guided by a pre-determined feasibility checklist, fidelity framework and theoretical framework of acceptability, respectively. Interviews will be analysed using the content analysis.DiscussionThe current study can determine the feasibility and fidelity of delivering a systematic, theoretically driven, tailored behaviour change intervention. It will also assess whether the intervention, its ingredients and delivery are acceptable to the farming population. This study will also inform the development of a future larger trial to test the effectiveness of the intervention.Trial registrationISRCTN Identifier: ISRCTN22219089. Date applied 29 July 2022
An efficient confidentiality protection solution for pub/sub system
Authors: Pei Jinglei , Shi Yuyang , Feng Qingling , Shi Ruisheng , Lan Lina , Yu Shui , Shi Jinqiao , Ma Zhaofeng 
Published: July 2023

AbstractPublish/subscribe(pub/sub) systems are widely used in large-scale messaging systems due to their asynchronous and decoupled nature. With the population of pub/sub cloud services, the privacy protection problem of pub/sub systems has started to emerge, and events and subscriptions are exposed when executing event matching on untrustworthy cloud brokers. However, as the number of subscriptions increases, the effectiveness of the previous confidentiality protection approaches declines drastically. In this paper, we propose SBM (scalable blind matching), an effective confidentiality protection scheme for pub/sub systems. To the best of our knowledge, SBM is the first scheme that applies order-preserving encryption algorithm to protect the system’s confidentiality and ensure its scalability. In this scheme, SBM-I is highly effective in subscription matching but is unable to achieve ideal security IND-OCPA, whereas SBM-II is suggested to ensure system security and SGX is used to reduce interaction and boost ciphertext matching performance. The experiment demonstrates that this method has better matching performance compared to others: the average matching time of SBM-I is 3–4 orders of magnitude faster than the matching algorithm MP and SGX-based algorithm SCBR when the number of subscriptions is 500,000, and the average matching time of SBM-II is 40 times faster than MP and 24 times than SCBR.