bluuebunny/crossref_metadata_2025_split huggingface dataset:
Night‐Time Apomorphine Infusion: Who Are the Best Candidates?
Authors: Cochen De Cock Valérie , Dodet Pauline , Leu‐Semenescu Smaranda , Aerts Cécile , Abril Beatriz , Castelnovo Giovanni , Landragin Nicolas , Drapier Sophie , Olivet Hélène , Corbillé Anne‐Gaëlle , Leclair‐Visonneau Laurène , Anheim Mathieu , Vidailhet Marie , Arnulf Isabelle , Doulazmi Mohamed , Roze Emmanuel ,   Post‐hoc analysis of the APOMORPHEE study
Published: May 2023

ABSTRACTBackgroundWe recently demonstrated in a randomized controlled trial (APOMORPHEE, NCT02940912) that night‐time only subcutaneous apomorphine infusion improves sleep disturbances and insomnia in patients with advanced Parkinson's disease and moderate to severe insomnia.ObjectivesTo identify the best candidates for receiving night‐time only subcutaneous apomorphine infusion in routine care.MethodsIn this post‐hoc analysis of APOMORPHEE, we compared the characteristics of patients according to whether they chose to continue night‐time only subcutaneous apomorphine infusion at the end of the study period or not.ResultsHalf of the patients (22/42) chose to continue the treatment. Off duration (day or night), painful Off dystonia, and insomnia severity at baseline were associated with night‐time only apomorphine continuation. Multivariate analysis retained only Off duration as an independent predictor of continuation.ConclusionsThe best candidates for night‐time only apomorphine are patients with severe and prolonged Off periods (day or night) and severe insomnia.
Super‐wideband two‐arm antenna for future generations of mobile communications
Authors: Ouf Eman G. , Abo El‐Hassan May , Farahat Asmaa E. , Hussein Khalid F. A. , Mohassieb Shaimaa A. 
Published: May 2023

AbstractIn this paper, a modified rhombic‐shaped wide‐flare two‐arm antenna is proposed for super‐wideband applications of the next generations of mobile technologies. To enhance antenna input impedance and to improve its performance, the copper arms are lithographed on a dielectric substrate with multilayers and fed through a wideband balun that is designed to feed the balanced two‐arm antenna through the conventional (unbalanced) coaxial line. The proposed antenna is fabricated for experimental validation of the simulation results. It is shown through electromagnetic simulation as well as experimental measurements that the proposed antenna is operational in the range of frequencies (). Parametric study is performed to obtain the optimum design of the proposed antenna. The distributions of the surface current on the antenna arms at different frequencies are presented and discussed for more understanding of the antenna operation over the entire frequency band. It is shown that the antenna has a radiation efficiency of greater than 96%, percentage bandwidth of 164%, ratio bandwidth of 10, bandwidth‐to‐dimension ratio of 1360, and maximum gain that exceeds .
Robust quantitative susceptibility mapping via approximate message passing with parameter estimation
Authors: Huang Shuai , Lah James J. , Allen Jason W. , Qiu Deqiang 
Published: May 2023

PurposeFor quantitative susceptibility mapping (QSM), the lack of ground‐truth in clinical settings makes it challenging to determine suitable parameters for the dipole inversion. We propose a probabilistic Bayesian approach for QSM with built‐in parameter estimation, and incorporate the nonlinear formulation of the dipole inversion to achieve a robust recovery of the susceptibility maps.TheoryFrom a Bayesian perspective, the image wavelet coefficients are approximately sparse and modeled by the Laplace distribution. The measurement noise is modeled by a Gaussian‐mixture distribution with two components, where the second component is used to model the noise outliers. Through probabilistic inference, the susceptibility map and distribution parameters can be jointly recovered using approximate message passing (AMP).MethodsWe compare our proposed AMP with built‐in parameter estimation (AMP‐PE) to the state‐of‐the‐art L1‐QSM, FANSI, and MEDI approaches on the simulated and in vivo datasets, and perform experiments to explore the optimal settings of AMP‐PE. Reproducible code is available at:
https://github.com/EmoryCN2L/QSM_AMP_PE.ResultsOn the simulated Sim2Snr1 dataset, AMP‐PE achieved the lowest NRMSE, deviation from calcification moment and the highest SSIM, while MEDI achieved the lowest high‐frequency error norm. On the in vivo datasets, AMP‐PE is robust and successfully recovers the susceptibility maps using the estimated parameters, whereas L1‐QSM, FANSI and MEDI typically require additional visual fine‐tuning to select or double‐check working parameters.ConclusionAMP‐PE provides automatic and adaptive parameter estimation for QSM and avoids the subjectivity from the visual fine‐tuning step, making it an excellent choice for the clinical setting.
Implementation and verification of a user‐defined element (UEL) for coupled thermal‐hydraulic‐mechanical‐chemical (THMC) processes in saturated geological media
Authors: Zhou Xiang , Zhang Yida 
Published: May 2023

AbstractEfficient and accurate modeling of the coupled thermal‐hydraulic‐mechanical‐chemical (THMC) processes in various rock formations is indispensable for designing energy geo‐structures such as underground repositories for high‐level nuclear wastes. This work focuses on developing and verifying an implicit finite element solver for generic coupled THMC problems in geological settings. Starting from the mass, momentum, and energy balance laws, a specialized set of governing equations and a thermoporoelastic constitutive model is derived. This system is then solved by an implicit finite element (FE) scheme. Specifically, the residuals and the Jacobians are scripted in a user‐defined element (UEL) subroutine which is then combined with the general‐purpose FE software Abaqus Standard to solve initial‐boundary value problems. Considering the complexity of the system, the UEL development follows a stepwise manner by first solving the coupled hydraulic‐mechanical (HM) and thermal‐hydraulic‐mechanical (THM) equations before moving on to the full THMC problem. Each implementation step consists of at least one verification test by comparing computed results with closed‐form analytical solutions to ensure that the various coupling effects are correctly realized. To demonstrate the robustness of the algorithm and to validate the UEL, a three‐dimensional case study is performed with reference to the in‐situ heating test of ATLAS at Belgium in 1980s. A hypothetical radionuclide leakage event is then simulated by activating the chemical‐concentration degree of freedom and prescribing a constant high concentration at the heater's surface. The model predicts a limited contaminated regime after six years considering both diffusion and advection effects on species transport.
Understanding factors influencing primary treatment with intradetrusor onabotulinumtoxinA versus augmentation cystoplasty in patients with spina bifida
Authors: Li Belinda , Peard Leslie M. , Zhao Shilin , Graham M. Kyle , Adams Cyrus , Taylor Abby S. , Thomas John C. , Pope John C. , Adams Mark C. , Brock John W. , Clayton Douglass B. 
Published: May 2023

AbstractPurposeSurgical interventions in the urologic management of children with neurogenic bladder secondary to spina bifida aim to preserve upper tract function, prevent urinary tract infections, and optimize quality of life. However, since the introduction of intravesical onabotulinumtoxinA (Botox) in the management of these patients, the indications for choosing Botox over augmentation cystoplasty (AC) remain undefined. The objective of this study was to determine which factors lead patients to undergo Botox versus AC as a primary surgical treatment after failing medical management.MethodsWe retrospectively reviewed the records of pediatric patients with myelomeningocele undergoing either primary Botox or primary AC at our institution between 2013 and 2018. We recorded demographic and clinical information. We identified 10 important clinical decision‐making factors: bladder trabeculation, vesicoureteral reflux, or hydronephrosis on imaging; end‐filling pressure (EFP) ≥40 cm H2O, detrusor overactivity, detrusor‐sphincter dyssynergia, or reduced capacity on urodynamic studies; physician‐perceived bladder hostility; and patient/family desire for continence and independence. The presence of these factors was compared between patients undergoing either primary Botox or primary AC.ResultsWe identified 14 and 50 myelomeningocele patients who underwent primary AC and primary Botox, respectively. We found no significant differences in age, sex, race, or history of reconstructive surgery (antegrade continence enema or catheterizable channel). For the 10 decision‐making factors, desire for independence/continence (p = <0.001) and reduced capacity (p = 0.002) were significantly associated with AC, while trabeculation (p = 0.006), EFP ≥40 cm H2O (p = 0.029), rising slope (p = 0.019), and physician‐perceived hostility (p = 0.012) were significantly more common with Botox.ConclusionsAt our institution, quality of life measures prompted AC over objective urodynamic or imaging findings before attempting Botox. These findings support a shared decision‐making approach when considering surgical intervention for neurogenic bladder secondary to myelomeningocele.
Chronic kidney disease awareness and updates on the management of diabetic kidney disease
Authors: Hamza Wigdan , Burton James O 
Published: May 2023

AbstractThe prevalence of chronic kidney disease (CKD) is rising worldwide and is a major contributor to morbidity and mortality. It is estimated to affect over 800 million people globally.CKD and its complications carry a substantial financial burden to the NHS in both primary and secondary care. The lack of public awareness of CKD and its complications leads to a reduction in planned follow‐up attendance; clinician awareness of the biomarkers of CKD and progression is still lacking. Measures to improve awareness are needed.Diabetes mellitus remains the single most common cause of progressive renal impairment and over 40% of patients with diabetes will develop diabetic kidney disease in their lifetime. A multidisciplinary approach to management and early intervention are therefore key to halt the progress of diabetic kidney disease. The National Institute for Health and Care Excellence has set clear guidelines for the management of diabetic kidney disease, highlighting newer therapeutic agents like SGLT2 inhibitors. New guidelines are also in place for referral to secondary care involving the Kidney Failure Risk Equation, as it identifies patients at increased risk of progressing to end stage kidney disease.Without robust measures for early detection and management of CKD, progression to kidney failure may occur, exacerbating the increase in cardiovascular disease, premature deaths and poor quality of life. This article is a call to action for the optimal and timely management of CKD. Copyright © 2023 John Wiley & Sons.
The weather's no joke for people living with diabetes
Authors: Greener Mark 
Published: May 2023

Climate change – presaging heat waves and cold snaps – along with drivers for global warming are likely to affect the epidemiology and management of diabetes, warns Mark Greener in his examination here of the published evidence to date.It has been shown that diabetes and climate change perpetuate each other in several ways. New literature offers detailed, thought‐provoking and worrying summaries.
Towards quantum state preparation with materials science: An analytical review
Authors: Sood Vaishali , Chauhan Rishi Pal 
Published: May 2023

AbstractThe field of quantum computing has undergone significant expansion and development in recent years. A quantitative and comprehensive examination of the research domain is essential to comprehend research trends and directions in the field. Henceforth, the current paper conducts a scientometric analysis of the academic literature on quantum computing retrieved from the Scopus database to understand the recent advances made by researchers in the domain. The analysis evaluates the state of the discipline's research by examining the most prominent journals and highly referenced articles. CiteSpace is leveraged to visualize the intellectual landscape of quantum state preparation by performing document co‐citation and author co‐citation analysis. The analysis reveals that trapped ions, photonic qubits, superconducting qubits, nitrogen‐vacancy centers, and nuclear spin qubits are the primary research topics in quantum computing. Furthermore, the most current research issues that require attention in the field are measurement‐based qubits, Majorana fermions, and quantum dots.
State‐of‐the‐art review of leak diagnostic experiments: Toward a smart water network
Authors: Bakhtawar Beenish , Zayed Tarek 
Published: May 2023

AbstractEffective water pipeline leak detection and localization can help water practitioners save water losses and reduce pipe rehabilitation budgets. Different sensing technologies can provide essential data aiding model development for predicting future leaks in the water distribution networks. Solutions for applying different sensing technologies to real water distribution networks are being developed for real‐time data collection, precise leak localization, reducing false alarms, and continuous pipeline monitoring. Experiments of different scales and specifications have been conducted to test the application and effectiveness of sensing technologies for leak diagnosis in water pipelines. Quality data collection is especially crucial for the successful implementation of these experiments. However, practitioners need help designing effective leak detection and localization experiments, wasting time, and resources. There needs to be a greater understanding of the design parameters for more accurate testing, such as sensor selection, sensor placement, ambient noise sources, and system operations. The current study, therefore, delineates design parameters for design leak diagnosis experiments for lab, testbed, and real networks. For application in real water networks, expert opinion is used to help identify the benefits and limitations and the implementation issues of available sensing technologies. An example experiment design using multi‐sensing technologies for smart leak diagnostics in Hong Kong is also presented. The study can guide water practitioners and researchers to design a multi‐sensing leak diagnostic experiments enabling a smart and sustainable utility management.This article is categorized under:
Engineering Water > Methods
Engineering Water > Sustainable Engineering of Water
Science of Water > Water Extremes
Outlier or Pioneer? the Development of Policy on E-Cigarettes in England
Authors: Berridge Virginia 
Published: May 2023

AbstractIn England, support for nicotine replacement therapy and for nicotine as a harm reduction agent expanded from the 1990s. The Labour government gave support as part of its anti-tobacco strategy and focus on inequalities. Action on Smoking and Health (ASH) the main anti-smoking activist organisation, also changed position. When e-cigarettes came on the scene ASH was important in including them within harm reduction and in assembling a coalition of support which included regulatory agencies. The coalition government also gave support. Medicinal licensing was intended but events in the European Parliament saw a consumer product approach adopted. The US EVALI epidemic did not affect England but shook public confidence. Recently, medicinal licensing has come back onto the agenda with a greater focus on young people.
Methode
Authors: Becker-Hingst Nadine 
Published: May 2023

ZusammenfassungIm Rahmen der Methode werden zunächst das Studiendesign und der Ablauf der Studie sowie die verschiedenen Erhebungsinstrumente, die zur Diagnostik und Beantwortung der Forschungsfragen eingesetzt wurden, beschrieben. Des Weiteren werden das Rekrutierungsprocedere, die Ein- und Ausschlusskriterien sowie eine deskriptive Beschreibung der entstandenen Stichproben dargestellt. Abschließend wird das Vorgehen bei der statistischen Auswertung der Ergebnisse vorgestellt.
TRIM21 ameliorates hepatic glucose and lipid metabolic disorders in type 2 diabetes mellitus by ubiquitination of PEPCK1 and FASN
Authors: Zhang Kaini , Yang Chen , Zhou Xin , Liang Jin , Guo Jianjin , Li Min , Zhang Yi , Shao Shulin , Sun Peng , Li Kai , Huang Jingjing , Chen Fang , Liang Xiubin , Su Dongming 
Published: May 2023

AbstractHepatic glucose and lipid metabolism disorders promote the development and progression of type 2 diabetes mellitus (T2DM), yet the underlying mechanisms are not fully understood. Here, we identify tripartite motif-containing protein 21 (TRIM21), a class IV TRIM family member, as a pivotal regulator of hepatic metabolism in T2DM for the first time. Bioinformatic analysis suggests that TRIM21 expression is significantly reduced in T2DM patients. Intriguingly, in a mouse model of obese diabetes, TRIM21 expression is predominantly reduced in the liver rather than in other metabolic organs. It is further demonstrated that hepatic overexpression of TRIM21 significantly ameliorates glucose intolerance, insulin resistance, hepatic steatosis, and dyslipidemia in obese diabetic mice. In contrast, the knockdown of TRIM21 promotes glucose intolerance, insulin resistance, and triglyceride accumulation. Mechanistically, both phosphoenolpyruvate carboxykinase 1 (PEPCK1) and fatty acid synthase (FASN) are the hepatic targets of TRIM21. We revealed that TRIM21 promotes the degradation of PEPCK1 and FASN through a direct protein–protein interaction mediated K48-linked ubiquitination. Notably, overexpression of PEPCK1 and FASN essentially abolished the beneficial effects achieved by TRIM21 overexpression in obese diabetic mice. Overall, our data demonstrate that TRIM21 is a novel regulator of hepatic metabolic disorder, and suggest TRIM21 as a promising therapeutic target for T2DM.
Therapiealternativen bei amyopathischer MDA5-positiver Dermatomyositis
Authors: Schumacher Falk , Wollsching-Strobel Maximilian , Kroppen Doreen , Schwarz Sarah Bettina , Strunk Johannes , Windisch Wolfram , Berger Melanie 
Published: May 2023

ZusammenfassungWir berichten über den Fall eines atypischen Therapieverlaufs bei amyopathischer MDA5-Antikörper-positiver Dermatomyositis mit Lungenbeteiligung. Aufgrund der schlechten Prognose erfolgte initial neben der Gabe von Prednisolon die frühzeitige Therapie mit Cyclophosphamid, gefolgt von Rituximab. Aufgrund des Therapieversagens erfolgte die Umstellung der Basistherapie auf Mycophenolat-Mofetil. Hierunter zeigte sich ein überraschend rascher positiver Verlauf bezüglich der Lungenveränderungen, der Hautveränderungen und der allgemeinen Krankheitsaktivität.
A unique resistance mechanism is associated with RBgh2 barley powdery mildew adult plant resistance
Authors: Moolhuijzen Paula , Ge Cynthia , Palmiero Elzette , Ellwood Simon R. 
Published: May 2023

Abstract
Key message
Gene expression at the RBgh2 locus indicates involvement in cAMP/G-protein-coupled signalling and innate immunity in barley powdery mildew adult plant resistance.

Abstract
Barley powdery mildew is a globally significant disease, responsible for reduced grain yield and quality. A major effect adult plant resistance gene, RBgh2, was previously found in a landrace from Azerbaijan. The atypical phenotype suggested different underlying genetic factors compared to conventional resistance genes and to investigate this, genome-wide gene expression was compared between sets of heterogeneous doubled haploids. RBgh2 resistance is recessive and induces both temporary genome-wide gene expression changes during powdery mildew infection together with constitutive changes, principally at the RBgh2 locus. Defence-related genes significantly induced included homologues of genes associated with innate immunity and pathogen recognition. Intriguingly, RBgh2 resistance does not appear to be dependent on salicylic acid signalling, a key pathway in plant resistance to biotrophs. Constitutive co-expression of resistance gene homologues was evident at the 7HS RBgh2 locus, while no expression was evident for a 6-transmembrane gene, predicted in silico to contain both G-protein- and calmodulin-binding domains. The gene was disrupted at the 5′ end, and G-protein-binding activity was suppressed. RBgh2 appears to operate through a unique mechanism that co-opts elements of innate immunity.
An analytical approach of multiple-aisle shuttle-based storage and retrieval systems
Authors: Eder Michael 
Published: May 2023

AbstractThis paper deals with a method for performance calculation of shuttle-based storage and retrieval system (SBS/RS) with tier-captive aisle-changing shuttles and different storage strategies. The shuttles are assigned to a certain number of aisles in this system. The invented approach takes place in the design process of SBS/RS. A continuous time open-queueing system with a limited capacity approach is applied. A discrete spatial value approach determines the inter-arrival times and service times. A probability-based model mentions the aisle changing. This approach is validated by comparison to a Monte-Carlo simulation. A European material handling provider gave the data used in this comparison to validate this approach. Finally, an example of the usage in the design process of SBS/RS of the invented analytical approach is depicted. The result is an increase in throughput with an increasing number of aisles per shuttle. Likewise, the storage strategy greatly influences the throughput between random storage and retrieval and same aisle storage and retrieval.
Decidability of CPC-irreducibility of subshifts of finite type over free groups
Authors: Ban Jung-Chao , Chang Chih-Hung , Wu Yu-Liang 
Published: May 2023

AbstractThis paper attempts to study the irreducibility on complete prefix code (CPC-irreducibility) of a Markov shift over a free group, a topological mixing property first considered for shift spaces over free semigroups that induces chaotic behavior such as the existence of a dense set of periodic points. An example shows that the $$({\textsf{d}},{\textsf{c}})$$

(
d
,
c
)

-reduction, an effective algorithm of determination of CPC-irreducibility of Markov shifts over free semigroups (Ban et al. in J Stat Phys 177:1043–1062, 2019), fails for general Markov shifts over free groups. This paper reveals an algorithm for determining the CPC-irreducibility of Markov shifts over both free semigroups and groups. Furthermore, such an examination is finitely checkable, and an upper bound for the complexity of the algorithm is provided.