bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nanoscale imaging of CD47 informs how plasma membrane modifications shape apoptotic cell recognition
Authors: Dufour Samy , Tacnet-Delorme Pascale , Kleman Jean-Philippe , Glushonkov Oleksandr , Thielens Nicole , Bourgeois Dominique , Frachet Philippe 
Published: February 2023

AbstractCD47 recognized by its macrophage receptor SIRPα serves as a “don’t eat-me” signal protecting viable cells from phagocytosis. How this is abrogated by apoptosis-induced changes in the plasma membrane, concomitantly with exposure of phosphatidylserine and calreticulin “eat-me“ signals, is not well understood. Using STORM imaging and single-particle tracking, we interrogate how the distribution of these molecules on the cell surface correlates with plasma membrane alteration, SIRPα binding, and cell engulfment by macrophages. Apoptosis induces calreticulin clustering into blebs and CD47 mobility. Modulation of integrin affinity impacts CD47 mobility on the plasma membrane but not the SIRPα binding, whereas CD47/SIRPα interaction is suppressed by cholesterol destabilization. SIRPα no longer recognizes CD47 localized on apoptotic blebs. Overall, the data suggest that disorganization of the lipid bilayer at the plasma membrane, by inducing inaccessibility of CD47 possibly due to a conformational change, is central to the phagocytosis process.
1,3a,6a-Triazapentalene derivatives as photo-induced cytotoxic small fluorescent dyes
Authors: Tsuji Daisuke , Nakayama Atsushi , Yamamoto Riko , Nagano Shuji , Taniguchi Takashi , Sato Ryota , Karanjit Sangita , Muguruma Naoki , Takayama Tetsuji , Itoh Kohji , Namba Kosuke 
Published: February 2023

Abstract1,3a,6a-Triazapentalene (TAP) is a compact fluorescent chromophore whose fluorescence properties vary greatly depending on the substituents on the TAP ring. This study investigated the photo-induced cytotoxicities of various TAP derivatives. Among the derivatives, 2-p-nitrophenyl-TAP showed significant cytotoxicity to HeLa cells under UV irradiation but no cytotoxicity without UV. In addition, the photo-induced cytotoxicity of 2-p-nitirophenyl-TAP was found to be cancer cell selective and effective against HeLa cells and HCT 116 cells. Under UV irradiation, 2-p-nitrophenyl-TAP generated reactive oxygen species (ROS) that induced an apoptosis and ferroptosis in cancer cells. Therefore, it was revealed that 2-p-nitrophenyl-TAP is the most compact dye that can generate ROS by photoirradiation.
Conductance spectroscopy of Majorana zero modes in superconductor-magnetic insulator nanowire hybrid systems
Authors: Singh Roshni , Muralidharan Bhaskaran 
Published: February 2023

AbstractThere has been recent interest in superconductor-magnetic insulator hybrid Rashba nanowire setups for potentially hosting Majorana zero modes at smaller external Zeeman fields. Using the non-equilibrium Green’s function technique, we develop a quantum transport model that accounts for the interplay between the quasiparticle dynamics in the superconductor-magnetic insulator bilayer structure and the transport processes through the Rashba nanowire. We provide an analysis of three-terminal setups to probe the local and non-local conductance in clean and disordered nanowires. We uncover the gap closing and reopening followed by the emergence of near-zero energy states, which can be attributed to topological zero modes in the clean limit. In the presence of a disordered potential, trivial Andreev bound states may form with signatures reminiscent of topological zero modes. Our results provide transport-based analysis of regimes that support the formation of Majorana modes in these hybrid systems while investigating the effect of disorder on devices.
An interactive model to assess pathways for agriculture and food sector contributions to country-level net-zero targets
Authors: Baudry Gino , Costa Luis , Di Lucia Lorenzo , Slade Raphael 
Published: February 2023

AbstractThe Food and agriculture system plays a determining role in many countries ambitions to achieve net-zero by 2050. Sector pathways consistent with this objective most frequently describe sustainable intensification as the dominant response. This narrows the option space for the agricultural sector and restricts its ability to address multiple sustainability issues simultaneously. Here we present an interactive model ARISE (AgRIculture and food SystEm interactive model) which allows stakeholders to design complementary food and agriculture sector pathways and build consensus. As a first case study, we provided an environment-oriented NGO assessment of a UK agroecology pathway and evaluate the benefits in comparison with alternative pathways available in the literature and developed by the UK Government. This shows how the ARISE model can enable the exploration of critical trade-offs between the multiple sustainability objectives.
Metagenomic and machine learning-aided identification of biomarkers driving distinctive Cd accumulation features in the root-associated microbiome of two rice cultivars
Authors: Cheng Zhongyi , Zheng Qiang , Shi Jiachun , He Yan , Yang Xueling , Huang Xiaowei , Wu Laosheng , Xu Jianming 
Published: February 2023

Abstract
Developing low-cadmium (Cd) rice cultivars has emerged as a promising avenue for food safety in Cd-contaminated farmlands. The root-associated microbiomes of rice have been shown to enhance rice growth and alleviate Cd stress. However, the microbial taxon-specific Cd resistance mechanisms underlying different Cd accumulation characteristics between different rice cultivars remain largely unknown. This study compared low-Cd cultivar XS14 and hybrid rice cultivar YY17 for Cd accumulation with five soil amendments. The results showed that XS14 was characterized by more variable community structures and stable co-occurrence networks in the soil-root continuum compared to YY17. The stronger stochastic processes in assembly of the XS14 (~25%) rhizosphere community than that of YY17 (~12%) suggested XS14 may have higher resistance to changes in soil properties. Microbial co-occurrence networks and machine learning models jointly identified keystone indicator microbiota, such as Desulfobacteria in XS14 and Nitrospiraceae in YY17. Meanwhile, genes involved in sulfur cycling and nitrogen cycling were observed among the root-associated microbiome of these two cultivars, respectively. Microbiomes in the rhizosphere and root of XS14 showed a higher diversity in functioning, with the significant enrichment of functional genes related to amino acid and carbohydrate transport and metabolism, and sulfur cycling. Our findings revealed differences and similarities in the microbial communities associated with two rice cultivars, as well as bacterial biomarkers predictive of Cd-accumulation capacity. Thus, we provide new insights into taxon-specific recruitment strategies of two rice cultivars under Cd stress and highlight the utility of biomarkers in offering clues for enhancing crop resilience to Cd stresses in the future.
Single-particle optical study on the effect of chloride post-treatment of MAPbI3 nano/microcrystals
Authors: Jin Handong , Mukherjee Amitrajit , Chouhan Lata , Steele Julian A. , de Jong Flip , Gao Yujie , Roeffaers Maarten B. J. , Hofkens Johan , Debroye Elke 
Published: February 2023

MACl post-treatment of MAPbI3 nanoparticles in a mixed solvent successfully suppresses surface traps, associated with an improved PL intensity and lifetime, brighter and longer ON-states in PL blinking, and a more stable, enhanced photocurrent.
Comparing Interventions With Speech-Generating Devices and Other Augmentative and Alternative Communication Modes: A Meta-Analysis
Authors: Pak Natalie S. , Bailey Kathryn M. , Ledford Jennifer R. , Kaiser Ann P. 
Published: February 2023

Purpose:
Optimal augmentative and alternative communication (AAC) systems for children with complex communication needs depend in part on child characteristics, child preferences, and features of the systems themselves. The purpose of this meta-analysis was to describe and synthesize single case design studies comparing young children’s acquisition of communication skills with speech-generating devices (SGDs) and other AAC modes.

Method:
A systematic search of published and gray literature was conducted. Data related to study details, rigor, participant characteristics, design information, and outcomes were coded for each study. A random effects multilevel meta-analysis was performed using log response ratios as effect sizes.

Results:

Nineteen single case experimental design studies with 66 participants (
M
age
= 4.9 years) met inclusion criteria. All but one study featured requesting as the primary dependent variable. Visual analysis and meta-analysis indicated no differences between use of SGDs and picture exchange for children learning to request. Children demonstrated preferences for and learned to request more successfully with SGDs than with manual sign. Children who preferred picture exchange also learned to request more easily with picture exchange than with SGDs.

Conclusions:
Young children with disabilities may be able to request equally well with SGDs and picture exchange systems in structured contexts. More research is needed comparing AAC modes with diverse participants, communication functions, linguistic complexity, and learning contexts.

Supplemental Material:

https://doi.org/10.23641/asha.22111181
Using Reference Values to Identify Profiles of Swallowing Impairment in a Case Series of Individuals With Traumatic Spinal Cord Injury
Authors: Valenzano Teresa J. , Smaoui Sana , Peladeau-Pigeon Melanie , Barbon Carly E. A. , Craven B. Cathy , Steele Catriona M. 
Published: February 2023

Purpose:
In this article, we illustrate use of a systematic approach to rating videofluoroscopic swallowing studies (VFSS), the Analysis of Swallowing Physiology: Events, Kinematics and Timing (ASPEKT) method. The method is applied to a clinical case series of individuals with a history of traumatic spinal cord injury (tSCI) requiring surgical intervention using a posterior approach. Previous studies suggest that swallowing is highly variable in this population given heterogeneity in mechanisms, location and extent of injury, and in surgical management approaches.

Method:
The case series involved 6 individuals who were at least 1 month postsurgery for management of tSCI. Participants completed a VFSS using a standardized bolus protocol. Each VFSS was blindly rated in duplicate using the ASPEKT method and compared with published reference values.

Results:
The analysis revealed considerable heterogeneity across this clinical sample. Penetration–aspiration scale scores of 3 or higher were not observed in this cohort. Of note, patterns of impairment did emerge, suggesting there are some commonalities across profiles in this population, including the presence of residue associated with poor pharyngeal constriction, reduced upper esophageal opening diameter, and short upper esophageal sphincter opening duration.

Conclusions:
Although the participants in this clinical sample shared a history of tSCI requiring surgical intervention using a posterior approach, there was great heterogeneity in swallowing profile. Using a systematic method to identify atypical swallowing parameters can guide clinical decision making for determining rehabilitative targets and measuring swallowing outcomes.
Programme de formation de formateur en simulation interprofessionnelle
Authors: Wiesner Conti Joanne , Picchiottino Patricia , Doureradjam Robert , Bosson Jean-Pierre , Paignon Adeline 
Published: February 2023

Contexte : Les professionnels et futurs professionnels de la santé ont pour mission de délivrer des soins sûrs et de qualité malgré la complexité croissante des problèmes de santé que présente la population. La collaboration interprofessionnelle est une des solutions prometteuses pour répondre, à long terme, à ces enjeux sanitaires et démographiques. En réponse à ces défis, le Centre interprofessionnel de simulation (CiS) a développé la simulation interprofessionnelle pour enseigner la collaboration interprofessionnelle aux étudiants des différentes filières de formation en santé ainsi qu’aux professionnels en activité. Problématique : Une enquête conduite au CiS a confirmé que la facilitation de simulations interprofessionnelles est particulièrement exigeante pour les formateurs et ce d’autant plus qu’ils l’effectuent en binômes interprofessionnels. Description du programme : Le CiS a donc développé un programme original de formation de formateurs en simulations interprofessionnelles pour leur permettre d’être à la fois efficaces et à l’aise lors de ces enseignements interprofessionnels. Ce programme se décline en trois niveaux : facilitation de simulation, éducation interprofessionnelle et co-facilitation de simulation interprofessionnelle. Au terme de la formation, il est attendu que les formateurs disposent des connaissances et compétences nécessaires à la co-facilitation de simulation interprofessionnelle. Les évaluations reflètent une haute qualité de la formation, avec une adéquation élevée de réponse aux besoins des formateurs. Ceux-ci indiquent augmenter leur niveau de compétences et de connaissances tant en facilitation de simulation qu’en enseignement interprofessionnel. Conclusion : Les formateurs formés sont de meilleurs vecteurs pour le transfert des compétences en collaboration interprofessionnelle auprès des étudiants et dans les milieux cliniques.
Intérêt d’un dispositif pédagogique de type Jigsaw ou « classe puzzle » en formation initiale d’orthophonie
Authors: Privat Lisa , Laloi Aude , Gatignol Peggy , Borel Stéphanie 
Published: February 2023

Contexte : La méthode Jigsaw ou « classe puzzle » est une approche pédagogique développée aux États-Unis qui redéfinit les rôles de chacun, enseignants et apprenants, dans l’apprentissage. Nous l’avons appliquée à la formation à la lecture labiale des étudiantes de troisième année d’orthophonie. But : Le but était d’évaluer l’efficacité en termes d’amélioration des compétences et la perception de l’intérêt pédagogique de cette méthode par les étudiantes de troisième année du premier cycle d’études en orthophonie. Cet enseignement a été proposé en visioconférence pendant la crise sanitaire. Méthodes : Six groupes de 18 étudiantes ont participé aux enseignements sous forme de deux séances de travaux dirigés. L’évaluation et l’auto-évaluation de la lecture labiale, ainsi que le retour sur le procédé pédagogique ont été recueillis de façon anonyme. Résultats : La compétence en lecture labiale et le sentiment d’auto-efficacité s’améliorent après les deux séances de travaux dirigés. Le procédé pédagogique est jugé intéressant, dynamique et concret par les étudiantes. Conclusion : L’approche Jigsaw a permis de rendre l’enseignement de lecture labiale plus vivant et d’améliorer les compétences des étudiantes de troisième année d’orthophonie. Des études ultérieures permettront de comparer l’efficacité de cette approche par rapport aux méthodes pédagogiques traditionnellement utilisées en formation paramédicale, à savoir l’enseignement magistral et les travaux dirigés axés sur la discussion de cas cliniques.
Tonometrie: Rückblick und Ausblick (Teil 2)
Authors: Yaïci Rémi , Geerling Gerd 
Published: February 2023

ZusammenfassungIn 2. Teil des Beitrags werden die sonstigen Kontakttonometer und die Nonkontakttonometrie präsentiert. Es wird anhand einer Revue der Literatur über den klinischen Wert der verschiedenen Methoden und den Wert der Multimodalität in der Tonometrie diskutiert; ferner werden die letzten Innovationen mit den telemetrischen IOD-Sensoren eingeführt.
Empfehlungen bei progredienter Myopie im Kindes- und Jugendalter
Authors:   Berufsverband der Augenärzte Deutschlands e. V. (BVA),   Deutsche Ophthalmologische Gesellschaft (DOG),   Bielschowsky Gesellschaft für Schielforschung und Neuroophthalmologie
Published: February 2023

ZusammenfassungSeit der letzten und gleichzeitig ersten Stellungnahme der deutschen ophthalmologischen Fachgesellschaften zu den Möglichkeiten der Minderung von Myopieprogression im Kindes- und
Jugendalter haben sich in der klinischen Forschung viele neue Details und Aspekte ergeben. Die nun vorliegende, zweite Stellungnahme aktualisiert das bisherige Dokuments und konkretisiert
die Empfehlungen sowohl zum Seh- und Leseverhalten als auch zu den pharmakologischen und optischen Therapieoptionen, die in der Zwischenzeit sowohl verfeinert als auch neu entwickelt
wurden.
Preferences and Satisfaction Toward an Orthodontic Clinical App
Authors: Thiradilok Sasipa , Witayabusarakhum Praeopailin , Jearnsujitwimon Oranut , Manopatanakul Somchai 
Published: February 2023

Abstract
Objectives To promote the development of professional orthodontic apps and to grow app engagement, many contributing factors should first be scrutinized. The main purpose of this research was to assess whether gap analysis facilitates strategic app design.
Materials and Methods Gap analysis was first conducted to reveal users' preferences. Then, the OrthoAnalysis app was developed on an Android operating system using Java programming language. Finally, a self-administered survey was issued to 128 orthodontic specialists to assess their satisfaction toward usage of the app.
Statistical Analysis The content validity of the questionnaire was ascertained using an index of Item-Objective Congruence of more than 0.5. The reliability of the questionnaire was also analyzed with Cronbach's Alpha reliability coefficient (ɑ = 0.87).
Results Besides the most important factor, “content,” many issues were listed, and all were required to engage users. A strong and engaging app should show accurate, trustworthy, and practical clinical analysis that operates smoothly and fast with ease, along with a user-friendly, appealing, and trustworthy interface. In short, because of the preliminary gap analysis that was done to evaluate the potential app engagement power prior to app design, the result of the satisfaction assessment showed that nine traits including overall satisfaction were of high levels.
Conclusions Orthodontic specialists' preferences were assessed using gap analysis and an orthodontic app was designed and appraised. This article presents the orthodontic specialists' preferences and summarizes the process of achieving app satisfaction. Therefore, to create a clinical app with strong engagement power, a strategic initial plan using gap analysis can be recommended.
Combined Endoscopic–Laparoscopic Surgery (CELS) in the Management of Early Colorectal Lesions
Authors: Wlodarczyk Jordan R. , Lee Sang W. 
Published: February 2023

AbstractOver 14 million colonoscopies are performed annually in the United States. With the growing number of colonoscopies comes corresponding increases in the rates of colectomies performed for benign polyps. These advanced adenomas have the potential, if removed early, to promote decreased rates of colon cancer and improve patient survival. Difficult to resect polyps may be located at colonic flexures, tortuous turns in the colon, the ileocecal valve, or the appendiceal orifice presenting a unique challenge to endoscopic resection. Various advanced endoscopic techniques are now available for the resection of these polyps such as endoscopic mucosal resection (EMR) and endoscopic submucosal dissection, but these techniques have a steep learning curve and are technically challenging. For the community colorectal surgeon, relatively simpler options include combined endoscopic and laparoscopic surgery (CELS) and full-thickness laparo-endoscopic colonic excision (FLEX) for either the endoscopic or laparoscopic removal of challenging polyps. The FLEX procedure resembled a nonanatomic wedge resection of the colon with polyp, while CELS resembles a laparoscopically augmented EMR. With the technical success rate for CELS reportedly between 74 and 97%, the postoperative complication rate of less than 5%, and polyp recurrence rates bordering less than 2%, these procedures have the capacity to safely facilitate the complete removal of difficult-to-resect endoscopic polyps. The purpose of this review is to both provide recommendations for CELS and FLEX utilization for the resection of polyps and describe our operative techniques and tips and tools for increasing the efficacy of these procedures.
Does Construct Type Matter? A Retrospective Review Comparing Outcomes of Distal Radius Fractures Treated with Standard Volar Plating versus Fragment-Specific Fixation
Authors: Bowers Mitchell , Gruenberger Eric , Jardaly Achraf H. , Wood Madison , Ko Andrew , D'Almeida Stacey , Rubin Todd A. 
Published: February 2023

Abstract
Background Treatment of intra-articular distal radius fractures (DRFs) rests on anatomic internal fixation. Fragment-specific fixation (FSF) is applied when fracture pattern is too complex for standard volar plating (SVP), oftentimes with potential increased risk of complications. We hypothesized that patients undergoing FSF would achieve less wrist range of motion (ROM) with higher risk of complications compared with SVP.
Methods We conducted a retrospective review of 159 consecutive patients undergoing DRF fixation from 2017 to 2020. Patients < 18 years old, < 8 weeks' follow-up, open fractures, ipsilateral trauma, and fractures requiring dorsal spanning plate were excluded. Patient demographics, specific construct type, AO fracture classification, ROM, and complications were assessed. ROM was calculated using average flexion, extension, supination, and pronation. t-Tests were used to determine differences in ROM among construct types.
Results Ninety-two patients met all inclusion criteria: 59 underwent SVP and 33 underwent FSF. Average wrist ROM for patients undergoing SVP was 57 degrees/50 degrees flexion-extension and 87 degrees/88 degrees supination-pronation; average ROM for patients undergoing FSF was 55 degrees/49 degrees flexion-extension and 88 degrees/89 degrees supination-pronation. No significant differences were identified when comparing final wrist flexion (p = 0.08), extension (p = 0.33), supination (p = 0.35), or pronation (p = 0.21). Overall reoperation rate was 5% and higher for FSF (12%) versus SVP (2%). Highest reoperation rate was observed in the double volar hook cohort (80%; N = 4).
Conclusion Construct type does not appear to affect final ROM if stable internal fixation is achieved. SVP and FSF had similar complication rates; however, double volar hook constructs resulted in increased reoperations likely from fixation failure and plate prominence.
Level of Evidence Level IV, retrospective review.
Influence of Solar Activity on Precise Orbit Prediction of LEO Satellites
Authors: Yuan Jun-Jun , Zhou Shan-Shi , Tang Cheng-Pan , Wu Bin , Li Kai , Hu Xiao-Gong , Liang Er-Tao 
Published: February 2023

Abstract
The perturbations of low earth orbit (LEO) satellites operating in the orbit of 300 ∼ 2000 km are complicated. In particular, the atmospheric drag force and solar radiation pressure force change rapidly over a short period of time due to solar activities. Using spaceborne global positioning system (GPS) data of the CHAMP, GRACE and SWARM satellites from 2002 to 2020, this paper studies in depth the influence of solar activity on LEO satellites’ precise orbit prediction by performing a series of orbit prediction experiments. The quality of GPS data is more susceptible to being influenced by solar activity during years when this activity is high and the changes in dynamic parameters are consistent with those of solar activity. The effects of solar activity on LEO orbit prediction accuracy are analyzed by comparing the predicted orbits with the precise ones. During years of high solar activity, the average root-mean-squares prediction errors at 10, 20, and 30 minutes are 0.15, 0.20, and 0.26 m, respectively, which are larger than the corresponding values in low-solar-activity years by 59%, 63%, and 68%, respectively. These results demonstrate that solar activity has a great influence on the orbit prediction accuracy, especially during high-solar-activity years. We should strengthen the real-time monitoring of solar activity and geomagnetic activity, and formulate corresponding orbit prediction strategies for the active solar period.