bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis of Inexpensive Ternary Metal Oxides by a Co‐Precipitation Method for Catalytic Oxidation of Carbon Monoxide
Authors: Cam Thanh Son , Anh Nguyen Phan Quang , Duc Bui Nguyen Minh , Thuy Nguyen Thi , Lei Juying , Thanh Nguyen Trung , Huy Nguyen Nhat 
Published: September 2023

AbstractBy using a simple co‐precipitation method, new Fe2O3‐based nanocatalysts (samples) were synthesized. The samples were composites of two or three transition metal oxides, MOx (M=Fe, Mn, Co, Ni, and Cu). The average size of CuO crystallites in the composites composed of two oxide components (CuO−Fe2O3) was about 14.3 nm, while in those composed of three (CuO−MnOx−Fe2O3), the composite's phase compositions were almost in the amorphous form when annealing the sample at 300 °C. The latter sample had a specific surface area higher than that of the former, 207.9 and 142.1 g/m2, respectively, explaining its higher catalytic CO oxidation. The CO conversion over the CuO−MnOx−Fe2O3‐300 catalyst (1 g of catalyst, 2600 ppm of CO concentration in air, and 1.0 L/min of gas flow rate) begins at about 40 °C; the temperature for 50 % CO conversion (t50) is near 82 °C; and CO removal is almost complete at t99 ≈110 °C. The activity of the optimal sample was tested in different catalytic conditions, thereby observing a high durability of 99–100 % CO conversion at 130 °C. The obtained results were derived from XRD, FTIR, BET, SEM, elemental analysis and mapping, as well as catalytic experiments.
Analysing applications of neuromarketing in efficacy of programmatic advertising
Authors: Bajaj Radheyshyam , Ali Syed Asif , Singh Surabhi 
Published: September 2023

AbstractIn this paper, there is exploration of the concept of neuromarketing as a newly developed strategy with economic potential deriving from human brain research. The central notion of the essay is that programmatic advertising can be used to better comprehend the idea of neuromarketing and its impact on consumers' decision‐making. So neuromarketing involves the scientific observation of brainwave activity, eye tracking, and skin response to determine how people's brains react to advertisements and other brand‐related communications. By studying the brain, these neuromarketing strategies can forecast how consumers will make decisions. The neuromarketing tactics' benefits and constraints are studied on a number of market input devices in the paper. The influence of various techniques of neuromarketing is studied from the available research studies and literature. In the recent years, the neuromarketing concept has been able to garner a lot of importance in its contribution to the marketing, advertising, and programmatic advertising has been immensely helped by the understanding of consumer decision making. The consumer behaviour has been able to be comprehended through neuromarketing techniques which are one of the key pillars of the purpose and running of programmatic advertising. A neuromarketing study shall be the helping hand for increasing customer base, market leadership, and converting them to loyal customers. It will help in programmatic advertising through the understanding of the advertiser with respect to the likes and wants of the customers and how consumer attention can be drawn. The consumer behaviour can be understood by the marketers in terms of how the consumers react to the advertising.
Prebiotic Synthesis of 3’,5’‐Cyclic Adenosine and Guanosine Monophosphates through Carbodiimide‐Assisted Cyclization
Authors: Coulon Rémi , Papoušková Barbora , Mohammadi Elmira , Otyepka Michal , Wunnava Sreekar , Šponer Jiří , Šponer Judit E. 
Published: September 2023

Abstract3’,5’‐Cyclic nucleotides play a fundamental role in modern biochemical processes and have been suggested to have played a central role at the origin of terrestrial life. In this work, we suggest that a formamide‐based systems chemistry might account for their availability on the early Earth. In particular, we demonstrate that in a liquid formamide environment at elevated temperatures 3’,5’‐cyclic nucleotides are obtained in good yield and selectivity upon intramolecular cyclization of 5’‐phosphorylated nucleosides in the presence of carbodiimides.
Biotransformation Of l‐Tryptophan To Produce Arcyriaflavin A With Pseudomonas putida KT2440
Authors: Bitzenhofer Nora Lisa , Classen Thomas , Jaeger Karl‐Erich , Loeschcke Anita 
Published: September 2023

AbstractNatural products such as indolocarbazoles are a valuable source of highly bioactive compounds with numerous potential applications in the pharmaceutical industry. Arcyriaflavin A, isolated from marine invertebrates and slime molds, is one representative of this group and acts as a cyclin D1‐cyclin‐dependent kinase 4 inhibitor. To date, access to this compound has mostly relied on multi‐step total synthesis. In this study, biosynthetic access to arcyriaflavin A was explored using recombinant Pseudomonas putida KT2440 based on a previously generated producer strain. We used a Design of Experiment approach to analyze four key parameters, which led to the optimization of the bioprocess. By engineering the formation of outer membrane vesicles and using an adsorbent in the culture broth, we succeeded to increase the yield of arcyriaflavin A in the cell‐free supernatant, resulting in a nearly eight‐fold increase in the overall production titers. Finally, we managed to scale up the bioprocess leading to a final yield of 4.7 mg arcyriaflavin A product isolated from 1 L of bacterial culture. Thus, this study showcases an integrative approach to improve biotransformation and moreover also provides starting points for further optimization of indolocarbazole production in P. putida.
Crack Monitoring on Concrete Structures using Robust Distributed Fiber Optic Sensors
Authors: Herbers Max , Richter Bertram , Marx Steffen 
Published: September 2023

AbstractThe possibility to measure strains continuously using distributed fiber optic sensors (DFOS) offers enormous potential for structural health monitoring. Cracks can be automatically detected, localized and crack widths calculated. To address the relevant questions of choosing the right DFOS and appropriate application technique for monitoring existing structures, two 4 m long reinforced concrete beams were loaded under service loads in a 4‐point bending test. The DFOS were either bonded directly to the smooth concrete surface or along a groove. For comparison, another DFOS was integrated into the specimen. It is demonstrated that with the used adhesive, a good strain transfer from the specimen to the DFOS can be ensured even with subsequent installation. In order to detect all cracks with high reliability, robust DFOS with a monolithic cross section should be preferred for the practical use. The accuracy of crack width measurement was verified through Reference measurement via digital image correlation. For the monolithic DFOS, all measurement deviations were within the tolerance range of ±0.05 mm. With layered sensing cables, significant misinterpretations occurred due to strongly damped strain curves.
Monitoring the Fatigue‐Induced Strain Evolution of Concrete Bridges using Fiber Optic Sensors
Authors: Becks Henrik , Brockmann Daniel , Hegger Josef , Classen Martin 
Published: September 2023

AbstractConcrete bridges with low shear reinforcement ratios erected in the mid‐20th century are subjected to rapidly increasing traffic loads in the last decades. In the absence of precise methods for assessing the remaining service life, the detection of the slightest damage (e.g., cracks and corrosion) immediately leads to a partial or complete restriction of traffic. Major parts of the ultimate fatigue capacity are therefore not yet utilized. Addressing the aspects of sustainability and capacity of traffic infrastructure, it is crucial to extend the service life of existing bridges by optimized assessment concepts that cover the development of the actual damage state of the critical structural components. Therefore, this paper presents a novel monitoring concept for the strain development of pre‐damaged concrete structures. First experimental studies demonstrate that Fiber Optic Sensors (FOS) are ideally suited to capture the strain development of concrete structures under fatigue loading. Therefore, the developed measurement concept is based on this technology and can contribute to extend the service life of concrete bridges through comprehensive monitoring strategies.
Towards an Automated Crack Monitoring using Distributed Fiber Optic Sensors
Authors: Richter Bertram , Herbers Max , Marx Steffen 
Published: September 2023

AbstractThe high spatial resolution of distributed fiber optic sensors enables quasi‐continuous strain measurements, which makes it a promising technology for structural health monitoring. From this quasi‐continuous strain data, location and width of cracks can be estimated. For major benefit to infrastructure maintenance, this crack width calculation is need to be automated. A framework for crack width estimation is presented, streamlining the different approaches for concrete and steel sensors, mainly differing in the compensation of tension stiffening. Relevant parameters for the analysis are identified and their influence is studied. Two sensors – a concrete embedded one and a reinforcement attached one – are used to estimate crack width using the presented framework. The results are compared to digital image correlation. Accurate estimates are achieved. Tension stiffening showed to have a negligible small influence on the estimated crack widths. The concrete embedded sensors have a higher sensitivity and are recommended for crack width monitoring.
Cutting Stock Problem (CSP) applied to Structural Optimization for the minimum waste cost
Authors: Cucuzza Raffaele , Domaneschi Marco , Rosso Marco Martino , Martinelli Luca , Marano Giuseppe Carlo 
Published: September 2023

AbstractIn this study, an optimization method to design simple truss structures for the evaluation of the optimal stock of existing elements is introduced. To achieve this goal, the well‐known Bin Packing Problem (BPP) will be implemented within the structural optimization procedure. Specifically, among all the BPP variants, one of the most common applications in real‐world cases is the Cutting Stock Problem (CSP) in which the objective is to produce dj copies of each item type j by employing the minimum number of bins. In the civil engineering field, structural optimization is often employed aiming to improve the load‐bearing capacity of the structure itself, i.e. maximization of the performance ratio through the minimization of the structure weight. However, this goal doesn't guarantee maximum efficiency in terms of minimization of waste during the industrial production phase. To overcome these limits, authors propose a stock‐constrained structural optimization in which a heuristic search technique is adopted and the best arrangement of bars whit the lowest cut‐off waste is obtained for a 10‐bar‐truss case study. For completeness reasons, a comparison between the solution obtained by the classic minimum weight optimization problem and the stock‐constrained one is discussed.
Shear strengthening of a concrete trough bridge using embedded through‐section (ETS) FRP bars
Authors: Carrasco Carlos Hermosilla , Farré Alfredo García , Gonzalez‐Libreros Jaime , Wang Chao , Carolin Anders , Kjellman Jouko , Sas Gabriel 
Published: September 2023

AbstractAs worldwide infrastructure is ageing, significant efforts have been paid to the development of strengthening techniques that will restore or increase the initial capacity of existing structures. Considering that it is expected that shear failure happens in a less ductile mode than that observed under bending actions, special attention has been devoted to shear strengthening methods. These methods included externally bonded fiber reinforced polymers (EB‐FRP), near‐surface mounted (NSM‐FRP) method, and the embedded trough‐section (ETS) technique, among others. In this paper, ETS method is used for the strengthening in shear of a reinforced concrete railway bridge located in Finland. The ETS method consists in the embedment of FRP or steel bars through predrilled holes into the concrete core. The bars are bonded to the concrete using adhesives. The paper includes a brief review of recent advances in the use of ETS and comparison with other available techniques, the description of the case study, instrumentation of the bars using fiber optic sensors (FOS) for strain monitoring, the procedure used for the installation of the bars in the field, and a preliminary analysis of the data collected.
Neutral Silylyne Complex of Molybdenum: Synthesis, Properties, and Access to Silaiminoacyl Complexes via [2+3] Cycloaddition
Authors: Hashimoto Hisako , Watanabe Kohei , Yoshimoto Takashi , Hayakawa Naoki , Matsuo Tsukasa , Tobita Hiromi 
Published: September 2023

AbstractA neutral silylyne complex of molybdenum was synthesized by the stepwise dehydrogenation method and its properties were compared with those of the tungsten analog. The complex takes a dimeric form as crystals but afford a monomer‐dimer equilibrium in solution. The replacement of the central metal from W to Mo led to a monomer dominant (~98 %) solution at room temperature. The monomer‐dimer dynamics was investigated based on thermodynamic parameters. The molybdenum silylyne complex underwent [2+2] cycloaddition with alkynes much faster than the tungsten analog. The reactions with organic azides led to the formation of the first example of silaiminoacyl complexes through [2+3] cycloaddition. The structures and bonding aspects of the products were clarified by multiple measurements and DFT calculations.
Chalcogen Bonding Catalysis: Tellurium, the Last Frontier?
Authors: Pale Patrick , Mamane Victor 
Published: September 2023

AbstractChalcogen bonding (ChB) is the non‐covalent interaction occurring between chalcogen atoms as Lewis acid sites and atoms or groups of atoms able to behave as Lewis bases through their lone pair or π electrons. Analogously to its sister halogen bonding, the high directionality of this interaction was implemented for precise structural organizations in the solid state and in solution. Regarding catalysis, ChB is now accepted as a new mode of activation as demonstrated by the increased number of examples in the last five years. In the family of ChB catalysts, those based on tellurium rapidly appeared to overcome their lighter sulfur and selenium counterparts. In this review, we highlight the Lewis acid properties of tellurium‐based derivatives in solution and summarize the start‐of‐the‐art of their applications in catalysis.
Yttrium Complexes with Group 13 Heterobenzene‐Type Ligands
Authors: Lebon Jakob , Barisic Damir , Maichle‐Mössmer Cäcilia , Anwander Reiner 
Published: September 2023

AbstractThe yttrium gallabenzene complex [(1‐Me‐3,5‐tBu2−C5H3Ga)(μ‐Me)Y(2,4‐dtbp)] is accessible from Y(GaMe4)3 and K(2,4‐dtbp) via a tandem salt metathesis/methane elimination (2,4‐dtbp=2,4‐di‐tert‐butyl‐pentadienyl). The pentadienyl ligand in [(1‐Me‐3,5‐tBu2−C5H3E)(μ‐Me)Y(2,4‐dtbp)] (E=Al, Ga) is easily displaced by salt metathesis with KC5Me5 and KTpMe,Me (TpMe,Me=tris(pyrazolyl‐Me2‐3,5)borato) affording [(1‐Me‐3,5‐tBu2−C5H3E)(μ‐Me)Y(TpMe,Me)] and [(1‐Me‐3,5‐tBu2−C5H3E)(μ‐Me)Y(C5Me5)]. The yttrium center in [(1‐Me‐3,5‐tBu2−C5H3E)(μ‐Me)Y(2,4‐dtbp)] readily forms adducts with neutral Lewis bases like 4‐DMAP (4‐dimethylaminopyridine), PMe3, DMPE (1,2‐bis(dimethylphosphino)ethane), and DME (1,2‐dimethoxyethane). In stark contrast, addition of TMEDA (N,N,N’,N’‐tetramethylethylenediamine) results in methyl/pentadienyl exchange between aluminum and yttrium resulting in [(1‐(2,4‐dtbp)‐1‐Me‐3,5‐tBu2−C5H3Al)Y(Me)(tmeda)]. The bonding features of the newly synthesized complexes are analyzed by single‐crystal X‐ray diffraction (SCXRD) and heteronuclear (89Y, 31P) NMR spectroscopy.
Halogen Bonding in Brominated BODIPY Crystals: a Crystallographic and Computational Study
Authors: Farfán‐Paredes Mónica , Labra‐Vázquez Pablo , González‐Antonio Oscar , Martínez‐Bourget Diego , Guzmán‐Cedillo Cristian , Galindo‐Hernández Aylin , Romero Margarita , Santillan Rosa , Farfán Norberto 
Published: September 2023

AbstractThe study of halogen bonds (XBs) has been a subject of great interest in recent years due to its clear application in catalysis, liquid crystals, and crystal engineering. In this study, we analyzed the intermolecular interactions, in particular halogen bonds in BODIPYs with an increasing number of bromine atoms. The computational study included analyses through three different methods: the first approach of close contacts provided by mercury, then the expanded approach of the electron density partition of the molecules in the crystals provided by the analysis of Hirshfeld surfaces, and finally, the approach of the Quantum Theory of Atoms in Molecules (QT‐AIM) to characterize the non‐covalent interactions through finding electron density critical points between atoms and between neighboring molecules. The use of different computational methods allowed to gain insight into the interactions directing the crystal packing as the number of bromine atoms increased in the BODIPY moiety. Monocoordinated and bifurcated halogen bonds involving halide/halide were found. The penta‐brominated BODIPY showed four‐center cyclic nodes where each node is linked via XBs. This kind of motif can be useful in supramolecular chemistry and self‐assembly.
Incidence, risk factors, and management of alpelisib‐associated hyperglycemia in metastatic breast cancer
Authors: Shen Sherry , Chen Yuan , Carpio Andrea , Chang Cassandra , Iyengar Neil M. 
Published: September 2023

AbstractPurposeThe combination of fulvestrant with alpelisib, a PI3K inhibitor, improves progression‐free survival in metastatic hormone receptor–positive, PIK3CA‐mutant breast cancer. This study describes the incidence, risk factors, and treatment of alpelisib‐associated hyperglycemia.MethodsPatients with metastatic breast cancer who received alpelisib from 2013 to 2021 at Memorial Sloan Kettering Cancer Center were included in this retrospective study. Alpelisib prescription dates and patient/tumor characteristics were abstracted from medical records. Risk factors associated with hyperglycemia and alpelisib dose reduction/discontinuation were evaluated using Pearson’s χ2 tests.ResultsAmong 247 patients, baseline median body mass index was 25.4 kg/m2 and median hemoglobin A1c (HbA1c) was 5.5%. A total of 152 patients (61.5%) developed any‐grade hyperglycemia and 72 patients (29.2%) developed grade 3–4 hyperglycemia; median time to onset was 16 days. A total of 100 patients (40.5%) received alpelisib on a clinical trial; rates of hyperglycemia were significantly higher in patients treated as standard care versus on a clinical trial (any‐grade hyperglycemia 80.3% vs. 34.0%, grade 3–4 hyperglycemia 40.2% vs. 13.0%, p < .001). Baseline HbA1c was significantly associated with development of hyperglycemia (p < .001) and alpelisib dose reduction/discontinuation (p = .015). Among those who developed hyperglycemia, 101 (40.9%) received treatment, most commonly with metformin. A total of 49 patients (19.8%) were referred to an endocrinologist, which was associated with SGLT2 inhibitor prescription (p = .007).ConclusionsRates of hyperglycemia among patients treated with alpelisib as standard care were significantly higher than patients treated on clinical trials. Elevated baseline HbA1c is associated with alpelisib‐induced hyperglycemia and requiring dose modification. Optimization of glycemic status before alpelisib initiation should become routine practice.
Detection of clinically actionable gene fusions by next‐generation sequencing‐based RNA sequencing of non–small cell lung cancer cytology specimens: A single‐center experience with comparison to fluorescence in situ hybridization
Authors: Diks John , Tang Zhenya , Altan Mehmet , Anderson Sarah , Chen Hui , Rashid Asif , Yang Richard Kenneth , Routbort Mark J. , Patel Keyur P. , Toruner Gokce A. , Medeiros L. Jeffrey , Tang Guilin , Luthra Rajyalakshmi , Roy‐Chowdhuri Sinchita 
Published: September 2023

AbstractBackgroundGenomic profiling is needed to identify actionable alterations in non–small cell lung cancer (NSCLC). Panel‐based testing such as next‐generation sequencing (NGS) is often preferred to interrogate multiple alterations simultaneously. In this study, we evaluate the utility of an RNA‐based NGS assay to detect genomic alterations in NSCLC cytology specimens and compare these results to fluorescence in situ hybridization (FISH) testing.MethodsA retrospective review was performed of 264 NSCLC cytology specimens that were concurrently tested for gene fusions by RNA‐based NGS and ALK, RET, and/or ROS1 by FISH.ResultsGenomic alterations were detected in 29 cases by NGS, including ALK, RET, ROS1, NTRK, NUTM1, and FGFR3 fusions and MET exon 14 skipping alterations. Of the 20 cases with ALK, RET, and ROS1 fusions detected by NGS, 16 (80%) were concordant with the corresponding FISH results. Three cases showed discordance, where EML4::ALK (n = 2) and SLC34A2::ROS1 (n = 1) fusions were not detected by the corresponding FISH assay; one case with EZR::ROS1 was inadequate for FISH. No gene fusions were detected in 181 cases by NGS and 54 cases failed testing. The concordance rates for detecting ALK, RET, and ROS1 fusions using NGS and FISH were 97%, 100%, and 99.5%, respectively.ConclusionRNA‐based NGS can be used to detect gene fusions in NSCLC cytology cases with high concordance with FISH results. However, RNA‐based NGS may have high failure rates and therefore a low threshold for reflexing inadequate cases to an orthogonal testing method is essential for comprehensive genomic profiling.
The Challenge of ab Initio Calculations in Small Neon Clusters
Authors: Ema Ignacio , Ramírez Guillermo , López Rafael , San Fabián Jesús , García de la Vega José M. 
Published: September 2023

AbstractWeakly bound neon dimer, trimer and tetramers are studied at HF and CCSD(T) levels using Dunning, ANO and SIGMA‐s basis sets. Their ground‐state binding energies are studied along with some structural properties. SIGMA‐s basis sets have been developed explicitly for this issue but in a manner that can be readily applied to other atoms for the study of larger weakly bound systems. The difficulties for attaining accurate results on these systems are assessed by the computation of total, atomization and correlation energies, as well as equilibrium distances, with several basis sets of increasing size, ranging from non‐augmented to double‐augmented versions. Extrapolations are proposed to predict stabilization energies and the results are compared with previously published data.
Time‐Resolved Spectroelectrochemical Dynamics of Carotenoid 8’‐apo‐β‐Carotenal
Authors: Keşan Gürkan , Özcan Emrah , Chábera Pavel , Polívka Tomáš , Fuciman Marcel 
Published: September 2023

AbstractThis work examines the influence of applied external voltage in bulk electrolysis on the excited‐state properties of 8′‐apo‐β‐carotenal in acetonitrile by steady‐state and ultrafast time‐resolved absorption spectroscopy. The data collected under bulk electrolysis were compared with those taken without applied voltage. The steady‐state measurements showed that although intensity of the S0‐S2 absorption band varies with the applied voltage, the spectral position remain nearly constant. Comparison of transient absorption spectra shows that the magnitude of the ICT‐like band decreases during the experiment under applied voltage condition, and is associated with a prolongation of the S1/ICT‐like lifetime from 8 ps to 13 ps. Furthermore, switching off the applied voltage resulted in returning to no‐voltage data within about 30 min. Our results show that the amplitude of the signal associated with the ICT state can be tuned by applying an external voltage.