bluuebunny/crossref_metadata_2025_split huggingface dataset:
International Tuberculum Sellae Meningioma Study: Preoperative Grading Scale to Predict Outcomes and Propensity-Matched Outcomes by Endonasal Versus Transcranial Approach
Authors: Magill Stephen T. , Schwartz Theodore H. , Couldwell William T. , Gardner Paul A. , Heilman Carl B. , Sen Chandranath , Akagami Ryojo , Cappabianca Paolo , Prevedello Daniel M. , McDermott Michael W. 
Published: July 2023

BACKGROUND AND OBJECTIVES:
Tuberculum sellae meningiomas are resected via an expanded endonasal (EEA) or transcranial approach (TCA). Which approach provides superior outcomes is debated. The Magill–McDermott (M-M) grading scale evaluating tumor size, optic canal invasion, and arterial involvement remains to be validated for outcome prediction. The objective of this study was to validate the M-M scale for predicting visual outcome, extent of resection (EOR), and recurrence, and to use propensity matching by M-M scale to determine whether visual outcome, EOR, or recurrence differ between EEA and TCA.

METHODS:
Forty-site retrospective study of 947 patients undergoing tuberculum sellae meningiomas resection. Standard statistical methods and propensity matching were used.

RESULTS:
The M-M scale predicted visual worsening (odds ratio [OR]/point: 1.22, 95% CI: 1.02-1.46, P = .0271) and gross total resection (GTR) (OR/point: 0.71, 95% CI: 0.62-0.81, P < .0001), but not recurrence (P = .4695). The scale was simplified and validated in an independent cohort for predicting visual worsening (OR/point: 2.34, 95% CI: 1.33-4.14, P = .0032) and GTR (OR/point: 0.73, 95% CI: 0.57-0.93, P = .0127), but not recurrence (P = .2572). In propensity-matched samples, there was no difference in visual worsening (P = .8757) or recurrence (P = .5678) between TCA and EEA, but GTR was more likely with TCA (OR: 1.49, 95% CI: 1.02-2.18, P = .0409). Matched patients with preoperative visual deficits who had an EEA were more likely to have visual improvement than those undergoing TCA (72.9% vs 58.4%, P = .0010) with equal rates of visual worsening (EEA 8.0% vs TCA 8.6%, P = .8018).

CONCLUSION:
The refined M-M scale predicts visual worsening and EOR preoperatively. Preoperative visual deficits are more likely to improve after EEA; however, individual tumor features must be considered during nuanced approach selection by experienced neurosurgeons.
Attenuated cerebellar phenotypes in Inpp4a truncation mutants with preserved phosphatase activity
Authors: Tran Dang Minh , Yoshioka Nozomu , Bizen Norihisa , Mori-Ochiai Yukiko , Yano Masato , Yanai Shogo , Hasegawa Junya , Miyashita Satoshi , Hoshino Mikio , Sasaki Junko , Sasaki Takehiko , Takebayashi Hirohide 
Published: July 2023

ABSTRACT
Phosphoinositides (PIPs) act as intracellular signaling molecules that regulate various cellular processes. Abnormalities in PIP metabolism cause various pathological conditions, including neurodegenerative diseases, cancer and immune disorders. Several neurological diseases with diverse phenotypes, such as ataxia with cerebellar atrophy or intellectual disability without brain malformation, are caused by mutations in INPP4A, which encodes a phosphoinositide phosphatase. We examined two strains of Inpp4a mutant mice with distinct cerebellar phenotypes: the Inpp4aΔEx1,2 mutant exhibited striatal degeneration without cerebellar atrophy, and the Inpp4aΔEx23 mutant exhibited a severe striatal phenotype with cerebellar atrophy. Both strains exhibited reduced expression of Inpp4a mutant proteins in the cerebellum. N-terminal-truncated Inpp4a proteins were expressed from the Inpp4aΔEx1,2 allele by alternative translation initiation and had phosphatase activity for PI(3,4)P2, whereas the Inpp4a mutant protein encoded by Inpp4aΔEx23 completely lacked phosphatase activity. Our results indicate that the diverse phenotypes observed in Inpp4a-related neurological diseases could be due to the varying protein expression levels and retained phosphatase activity in different Inpp4a variants. These findings provide insights into the role of INPP4A mutations in disease pathogenesis and may help to develop personalized therapy.
Membrane insertases at a glance
Authors: Kizmaz Büsra , Herrmann Johannes M. 
Published: July 2023

ABSTRACT
Protein translocases, such as the bacterial SecY complex, the Sec61 complex of the endoplasmic reticulum (ER) and the mitochondrial translocases, facilitate the transport of proteins across membranes. In addition, they catalyze the insertion of integral membrane proteins into the lipid bilayer. Several membrane insertases cooperate with these translocases, thereby promoting the topogenesis, folding and assembly of membrane proteins. Oxa1 and BamA family members serve as core components in the two major classes of membrane insertases. They facilitate the integration of proteins with α-helical transmembrane domains and of β-barrel proteins into lipid bilayers, respectively. Members of the Oxa1 family were initially found in the internal membranes of bacteria, mitochondria and chloroplasts. Recent studies, however, also identified several Oxa1-type insertases in the ER, where they serve as catalytically active core subunits in the ER membrane protein complex (EMC), the guided entry of tail-anchored (GET) and the GET- and EMC-like (GEL) complex. The outer membrane of bacteria, mitochondria and chloroplasts contain β-barrel proteins, which are inserted by members of the BamA family. In this Cell Science at a Glance article and the accompanying poster, we provide an overview of these different types of membrane insertases and discuss their function.
Spectral sensitivity of retinal photoreceptors of tortricid moths is not tuned to diel activity period
Authors: Martín-Gabarrella Alejandro , Gemeno César , Belušič Gregor 
Published: July 2023

ABSTRACT
Leafrollers (Lepidoptera: Tortricidae) are a large family of small moths containing over 10,000 species, many of which are crop pests. Grapholita molesta, Lobesia botrana and Cydia pomonella adults are sexually active before, during and after sunset, respectively. We wanted to determine whether being active at different times of the day and night is associated with differences in their visual system. Spectral sensitivity (SS) was measured with electroretinograms and selective adaptation with green, blue and ultraviolet light. SS curves could be fitted with a triple nomogram template which indicated the existence of three photoreceptor classes peaking at 355, 440 and 525 nm. The retinae showed clear regionalization, with fewer blue receptors dorsally. No differences among species or between sexes were found. Intracellular recordings in C. pomonella also revealed three photoreceptor classes with sensitivities peaking at 355, 440 and 525 nm. The blue photoreceptors showed inhibitory responses in the green part of the spectrum, indicating the presence of a colour-opponent system. Flicker fusion frequency experiments showed that the response speed was similar between sexes and species and fused at around 100 Hz. Our results indicate that the three species have the ancestral insect retinal substrate for a trichromatic colour vision, based upon the UV, blue and green-sensitive photoreceptors, and lack any prominent adaptations related to being active under different light conditions.
Vitamin C Supplementation and Athletic Performance: A Review
Authors: Rogers Dylan R. , Lawlor Denis J. , Moeller James L. 
Published: July 2023

Abstract
Many athletes utilize high-dose vitamin C supplementation to optimize athletic performance. A review of research over the past 10 years on the use of vitamin C and athletic performance show mixed results. Fourteen randomized control trials were reviewed. In most studies, vitamin C was used with at least one additional supplement, usually vitamin E. Three studies showed positive outcomes associated with decreased markers of muscle damage after intense exercise with some form of vitamin C supplementation. The remaining 11 articles showed either neutral or negative effects of high dose vitamin C supplementation on muscle damage, physical performance, perceived muscle soreness, and/or adaptations to training. Based on a lack of consistent data and potential for blunted physiologic adaptations to training, long-term high-dosage supplementation with vitamin C is not recommended. Athletes should obtain antioxidants through a nutrient-rich diet instead of through supplement use.
Association between living with children, vaccination, and outcomes from COVID-19: an OpenSAFELY cohort study of 12 million adults in England during 2021–22
Authors: Cowling Thomas E , Forbes Harriet , Wing Kevin , Tazare John , Schultze Anna , Morton Caroline E , Bacon Sebastian , MacKenna Brian , Walker Alex J. , Hulme Will , Bates Chris , Mehrkar Amir , Curtis Helen J. , Evans David , Inglesby Peter , Davy Simon , Cockburn Jonathan , Parry John , Hester Frank , Harper Sam , Douglas Ian J , Evans Stephen J W , Bhaskaran Krishnan , Williamson Elizabeth J , Eggo Rosalind M , Goldacre Ben , Tomlinson Laurie A 
Published: July 2023

Background: Living with children has been associated with greater risks of SARS-CoV-2 infection, COVID-19 hospitalisation, and COVID-19 death. We examined how these associations varied during 2021–22 and according to the COVID-19 vaccination status of adults. Methods: We carried out a population-based cohort study, with the approval of NHS England. Primary care data and pseudonymously-linked hospital and death records from England, between 20th December 2020 and 21st February 2022, were used for adults (≥18 years) registered at a general practice on 20th December 2020. Adjusted hazard ratios (HRs) for SARS-CoV-2 infection, COVID-19 hospitalisation, or COVID-19 death, by presence of children in the household were calculated. Results: The cohort included 9,417,278 adults aged ≤65 years and 2,866,602 adults aged >65 years. Adults aged ≤65 years living with children of any age (versus no children) had greater risks of SARS-CoV-2 infection and COVID-19 hospitalisation (but not COVID-19 death), both when schools were open and closed (e.g. HR=1.50, 95% CI:1.49-1.51, for SARS-CoV-2 infection in the ‘Omicron dominant’ period, when schools were open, in adults living with children aged 0–11 years only). These associations also existed for adults aged >65 years, and there was some evidence that adults living with children also had greater risks of COVID-19 death. Vaccinated adults living with children had greater risks of SARS-CoV-2 infection, but lower risks of COVID-19 hospitalisation and death, than unvaccinated adults not living with children. Conclusions: In an era of widespread adult vaccination, adults living with children remained at increased risk of SARS-CoV-2 infection and COVID-19 hospitalisation.
The Avon Longitudinal Study of Parents and Children - a resource for COVID-19 research: questionnaire data capture July 2021 to December 2021, with a focus on long COVID
Authors: Northstone Kate , Suarez-Perez Almudena , Matthews Sarah , Crawford Michael , Timpson Nicholas 
Published: July 2023

ALSPAC, the Avon Longitudinal Study of Parents and Children is a prospective population-based cohort study. Pregnant women were recruited in 1990-1992 and the study has followed them, their partners (Generation 0; G0) and their offspring (Generation 1; G1) for over 30 years. During the coronavirus 2019 (COVID-19) pandemic, ALSPAC deployed a series of online questionnaires to capture participant experiences during this unprecedented time. In July 2021, a fifth questionnaire was deployed which primarily focussed on the symptoms of long COVID, also known as post-COVID syndrome. G0 and G1 participants were offered both online and paper questionnaires between 21st July 2021 and 11th December 2021. Of 21,138 invitations, 11,148 (52.8%) participants returned the questionnaire (4,763 original mothers [mean age 59.1 years], 2,074 original fathers/partners [mean age 62.0 years] and 4,311 offspring [mean age 29.0 years]). Of these 11,148 participants, 2835 (25.4%) had not completed any of the previous COVID-19 questionnaires, while 3480 (31.2%) had returned all four previous questionnaires. In this questionnaire, 1077 participants (9.8%) reported a previous positive COVID-19 test over the course of the pandemic. Of these, 109 (1.0%) had received medical advice that they likely had COVID-19, and 838 (7.6%) suspected that they had had COVID-19. Almost a third of participants (n=796, 31.1%) reported possible long COVID (experiencing symptoms for at least 4 weeks), whilst 351 (13.7%) reported symptom duration of 12 weeks or more (post-COVID syndrome). G0 mothers were more likely to report a longer duration of symptoms compared to their partners and their children. The fifth COVID-19 questionnaire deployed by ALSPAC and the data obtained from are described in this data note.
The Influence of Modern Trends in the Development of the Creative Economy on the Education System
Authors: Vakhorina Marina 
Published: July 2023

The aim of the study is an integration approach in the implementation of current business risk management problems through a new management technology that is becoming increasingly in demand in Russian practice. Research objectives: the theoretical provisions of the unit economy composition are substantiated; the indicators for assessing the business at the stage of creation are determined; the influence of the unit economy as an integral part of the business model is disclosed in order to ensure the viability of client–oriented entrepreneurship.
Results and practical significance. The presented research reveals the theoretical foundations and reveals the specific features inherent in the unit-economy system. Determines the economic content of the indicators of the new management model and the relationship between them. Practical approaches to the use of unit economics in the conditions of economic crisis are illustrated and the connection of unit economics with the management accounting system is substantiated. The work uses general scientific methods, in particular, the method of systematization and critical evaluation, practical methods of generalization and system reasoning. The historical prerequisites for the emergence of the unit economy are determined. The methodological features of the unit-economy, which formalized it into an independent management technology, are revealed.
The results obtained reflect the scientific novelty: the provisions that explain the use of unit economics as an integral part of the business model in a crisis economy are substantiated and the procedures for further development of new management technology for the purpose of efficiency and stimulation of entrepreneurial activity are predicted.
The results of the study can be used as recommendations on business risk management in practical activities by entrepreneurs, as well as a theoretical basis for further research on this topic.
Mobile Payment Adoption: An Empirical Investigation of Alipay
Authors: Xu Yuqian , Ghose Anindya , Xiao Binqing 
Published: July 2023

The rapid growth in the adoption of mobile payments has already begun to reshape bank payment practices. Utilizing a unique data set from a leading bank in Asia that records credit card transactions of its customers before and after the launch of Alipay mobile payment, the largest mobile payment platform in the world, this study aims to understand the impact of mobile payment adoption on bank customer credit card activities and the change of this impact after the mobile payment expansion. To do so, we employ the difference-in-differences method coupled with matching to estimate the effects. We find that mobile payment adoption not only increases customer credit card activities at the focal bank through both off-line and online channels, but also enhances customer loyalty to the bank by reducing churn. Specifically, the total credit card transaction amount and frequency of our focal bank increased by 9.4% and 10.7%, respectively. Moreover, we examine the change in the treatment effect after the mobile payment expansion and find an increase in adopters’ credit card activities and a reduction in their churn after the expansion. Next, we discuss the underlying mechanisms and show that mobile payment acts as a substitute for physical card payment in the off-line channel, and this supports the key underlying mechanism of the reduced transaction cost. However, a certain complementary effect exists between personal computer and mobile payments, likely driven by the coadoption of the two. Finally, we provide empirical evidence on conditions that facilitate the use of mobile payments, following the unified theory of acceptance and use of technology. History: Yong Tan, Senior Editor; Tianshu Sun, Associate Editor. Funding: This work was supported by National Natural Science Foundation of China [Grants U1811462, 72071102]. Supplemental Material: The online appendix is available at https://doi.org/10.1287/isre.2021.0156 .
CFD Simulation of Porous Canopy Heat Transfer in Apple Orchard-Based Frost Protection
Authors: Hua Weiyun , Heinemann Paul , He Long , Yuan Wenan 
Published: July 2023

Highlights

Convective heat transfer in an apple orchard was simulated by Ansys Fluent.

The various heating patterns and convective heat transfer coefficients under different heating schemes were obtained.

The heating effects of heater output intensity, output velocity, and heating angle were simulated.

The heating duration and heat dissipation time were critical for mobile heating.

Abstract. Frost events cause high economic losses in agriculture. Frost protection methods, particularly heating, have been implemented in cold-sensitive crops for millennia. Although often effective, traditional heating strategies can be insufficient or wasteful due to a lack of spatial temperature information, resulting in inadequate protection or uneven heating problems. Computational fluid dynamics (CFD) modeling has been widely used to simulate fluid flow, heat, and mass transfer by predicting various processes such as spatial flow velocity, pressure, and temperature distribution within a simulated environment. A three-dimensional CFD model for simulating airflow and heat transfer in an apple orchard was developed and validated, with the effects of heater output intensity and output velocity, heating angle, and heating duration analyzed. The validated model effectively predicted the spatial temperature changes over time inside the canopy for three representative heating schemes (heaters angled 0°, 45°, and 90° toward a tree row) with an average root mean square error (RMSE) of 2.6 °C. The simulated results show that the heating scheme of heaters angled 45° was the most effective, resulting in the largest average percentage of the protected canopy (72.3%), compared with heaters angled 0° (33.1%) and 90° (56.5%). The average percentage of the protected canopy increased by 108.2% when the heater output intensity increased to 477,000 KJ·h-1 and 46.0% when the heater output velocity increased to 15 m·s-1. However, the percentage of the protected canopy showed diminishing returns as the heater output intensity and velocity increased. The simulated heat dissipation time was linearly related to the heating duration, which can be utilized to determine the reheating time for mobile heating. The outcome of the study can be beneficial for making effective frost protection decisions in apple orchards. Keywords: Canopy, Computational fluid dynamics, Frost protection, Heat transfer, Porous media modeling.
DIFICULDADES NA APRENDIZAGEM DE LÍNGUAS E MEIOS DE INTERVENÇÃO
Authors: Brun Milenna 
Published: July 2023

Este trabalho examina as manifestações psíquicas que dificultam a aprendizagem de língua estrangeira por adultos e análisa as possibilidades de intervenção eficaz a fim de auxiliar e facilitar o processo de aquisição lingüística. Tentamos compreender quem são esses aprendizes, suas dificuldades para aprender uma língua estrangeira e as relações que eles mantêm com a língua e a cultura estrangeiras, com o professor e com a situação educativa. Refletimos ainda sobre as ações viáveis no quadro atual do ensino de línguas para adultos tais como a utilização de estratégias de aprendizagem e de atividades lúdicas. O artigo apresenta um programa de intervenção – o projeto de escuta sistemática – que considera os aspectos subjetivos da aprendizagem.
Adverse birth outcomes and associated factors among newborns delivered in Sao Tome & Principe: A case‒control study
Authors: Vasconcelos Alexandra , Sousa Swasilanne , Bandeira Nelson , Alves Marta , Papoila Ana Luísa , Pereira Filomena , Machado Maria Céu 
Published: July 2023

Background
Newborns with one-or-more adverse birth outcomes (ABOs) are at greater risk of mortality or long-term morbidity with health impacts into adulthood. Hence, identifying ABO-associated factors is crucial for devising relevant interventions. For this study, ABOs were defined as prematurity (PTB) for gestational age <37 weeks, low birth weight (LBW) <2.5 kg, macrosomia >4 kg, asphyxia for a 5-minute Apgar score <7, congenital anomalies, and neonatal sepsis. This study aimed to assess factors associated with ABOs among babies delivered at the only hospital of Sao Tome & Principe (STP), a resource-constrained sub-Saharan-Central African country.

Methods
A hospital-based unmatched case‒control study was conducted among newborns from randomly selected mothers. Newborns with one-or-more ABO were the cases (ABO group), while healthy newborns were the controls (no-ABO group). Data were collected by a face-to-face interview and abstracted from antenatal care (ANC) pregnancy cards and medical records. Multivariable logistic regression analysis was performed to identify ABO-associated factors considering a level of significance of α = 0.05.

Results
A total of 519 newborns (176 with ABO and 343 no-ABO) were enrolled. The mean gestational age and birthweight of cases and controls were 36 (SD = 3.7) weeks with 2659 (SD = 881.44) g and 39.6 (SD = 1.0) weeks with 3256 (SD = 345.83) g, respectively. In the multivariable analysis, twin pregnancy [aOR 4.92, 95% CI 2.25–10.74], prolonged rupture of membranes [aOR 3.43, 95% CI 1.69–6.95], and meconium- fluid [aOR 1.59, 95% CI 0.97–2.62] were significantly associated with ABOs. Eight or more ANC contacts were found to be protective [aOR 0.33, 95% CI 0.18–0.60, p<0.001].

Conclusion
Modifiable factors were associated with ABOs in this study and should be considered in cost-effective interventions. The provision of high-quality ANC should be a priority. Twin pregnancies and intrapartum factors such as prolonged rupture of membranes and meconium-stained amniotic fluid are red flags for ABOs that should receive prompt intervention and follow-up.