bluuebunny/crossref_metadata_2025_split huggingface dataset:
The application of fluoroscopic criteria to define leadless pacemakers implant position and the effect of location on device performance
Authors: ElRefai Mohamed , Menexi Christina , Abouelasaad Mohamed , Roberts Paul 
Published: May 2023

Objective:
Leadless pacemakers (LPs) were designed to avoid complications associated with transvenous pacing. To minimise risk of perforations, there is preference towards implanting LPs into the septum rather than the apex or free wall.
An objective yet feasible way of characterising the LP location is currently lacking. We report a simple radiological method of defining LP position and our analysis of the impact of implantation site on performance of LPs.

Methods:
The first 100 LPs implanted at our UK centre were reviewed and the devices’ positions in fluoroscopy images and X-rays based on conventional criteria for lead positions and conventional practice for LPs positioning were assessed. The devices’ electrical parameters at implant and at the latest device follow-up were used to compare performance between implantation sites.

Results:
35.6% of implants were in the apex. 31.1% in mid-septum, 16.7% in apical septum, 15.5% on the septal right ventricular inflow and 1.1% in the septal RV outflow tract. We had no major complications.
Thresholds, R-wave amplitudes, and impedance averaged at 0.67 ± 0.41 V, 10.64 ± 5.30 mV, and 777.67 ± 201.67 Ohms, respectively, at the time of implantation, and 0.66 ± 0.39 V, 14.08 ± 6.14 mV, and 564.29 ± 96.76 Ohms at the last device check. There was no difference in the pacing thresholds or impedance between implant sites.

Conclusions:
We propose a simple, reproducible way of defining the LP location which can help standardise the assessment of the device location sites across LP implantation centres.

Advances in knowledge:
Emphasis on the safety and reliability of the leadless pacemakers in a real-world setting.
Establishing the variation in the implantation sites for leadless pacemakers and reporting the effect of the implantation sites on the devices’ performance.
We propose a simple, reproducible way of defining the LP location which can help standardise the assessment of the device location sites across LP implantation centres.
Variability in soil properties influencing pigeonpea (Cajanus cajana L.) yield: a multivariate statistical analysis
Authors: N L Rajesh , K Narayana Rao , U Sathishkumar , V B Wali , K Basavaraj , H V Rudramurthy , B K Desai 
Published: May 2023

Aims: The aim of the study was to reveal the variability in soil properties influencing pigeonpea (Cajanus cajana L.) seed yield under semi-arid rainfed condition. Methods: Soils were initially classified into series level and further these series were divided into soil-phase units. For two site years viz., 2018-19 and 2019-20, surface soil samples from each soil-phase unit were collected before sowing of pigeonpea and subsequently crop growth parameters at critical stages were recorded. Results: The principal component analysis with varimax rotation resulted in seven components for both the site years, having eigenvalues greater than one, explained more than 80% of the variability. The step wise linear regression analysis showed that the pigeonpea seed yield was linearly correlated with PC3 (p<0.01), PC4 (p<0.01) and PC7 (p<0.05) of soil properties with R2 = 0.679, during 2018-19. Whereas, during 2019-20, the seed yield was linearly correlated with PC1 (p<0.01), PC3 (p<0.01) and PC6 (p<0.05) with R2 = 0.677. In site year 1, the available P2O5, Fe, Zn, S, Cu, number of pods, surface soil moisture determined the yield. In site year 2, the available K2O, P2O5, Fe, Zn, S, clay, CEC and available water content determined the yield. All these variables together explain variability in yield.
Practical tips for starting a successful national postgraduate course
Authors: Sundbom Magnus 
Published: May 2023

Background: Few start national courses, and those that do usually do it once. The aim of this paper is to outline an approach to conduct a successful national postgraduate course. Methods: The practical tips were derived from personal experience. Results: The 12 tips identified are: define learning needs and curriculum, create a functioning structure, recruit a committed faculty, obtain legitimacy, promote your course, try out the concept, establish administrative support, use modern techniques and accessories, create course-related social activities, keep all on board, collect ongoing evaluation, and stay in control. Conclusion: It is hoped that these tips will make it easier for others to take the decisive first step in the exciting task of starting a national course; that is: ‘to know the road ahead - ask those coming back’.
A Converging Benders’ Decomposition Algorithm for Two-Stage Mixed-Integer Recourse Models
Authors: van der Laan Niels , Romeijnders Ward 
Published: May 2023

Novel Optimality Cuts for Two-Stage Stochastic Mixed-Integer Programs The applicability and use of two-stage stochastic mixed-integer programs is well-established, thus calling for efficient decomposition algorithms to solve them. Such algorithms typically rely on optimality cuts to approximate the expected second stage cost function from below. In “A Converging Benders’ Decomposition Algorithm for Mixed-Integer Recourse Models,” van der Laan and Romeijnders derive a new family of optimality cuts that is sufficiently rich to identify the optimal solution of two-stage stochastic mixed-integer programs in general. That is, general mixed-integer decision variables are allowed in both stages, and all data elements are allowed to be random. Moreover, these new optimality cuts require computations that decompose by scenario, and thus, they can be computed efficiently. Van der Laan and Romeijnders demonstrate the potential of their approach on a range of problem instances, including the DCAP instances from SIPLIB.
Facial cellulitis caused by Candida guilliermondi in an immunocompetent patient: a rare case report
Authors: Tolaj Ilir , Gashi Visar , Bunjaku Gramoz , Mehmeti Murat , Fejza Hajrullah 
Published: May 2023

Background: Candida cellulitis is a rare disease, primarily reported in immunocompromised patients. Atypical Candida spp. infections are increasing, largely due to the growing number of immunocompromised patients. This case report describes a 52-year-old immunocompetent patient with facial cellulitis caused by Candida guilliermondi. Candida guilliermondi has not previously been reported as a cause of facial cellulitis in either immunocompromised or immunocompetent patients. Case presentation: A 52-year-old, otherwise healthy, male patient presented with facial cellulitis that did not respond to intravenous antibiotics. Culture of the drained pus revealed Candida guilliermondi. The patient was successfully treated with intravenous fluconazole. Conclusion: This case highlights the possibility of atypical Candida spp. causing deep facial infections in immunocompetent patients. Candida guilliermondi has not been previously reported as a cause of facial cellulitis in either immunocompromised or immunocompetent patients. Healthcare providers should consider atypical Candida spp. infections in the differential diagnosis of deep facial infections in both immunocompromised and immunocompetent patients.
Ultra-CEP-stable single-cycle pulses at 2.2  µm
Authors: Kowalczyk Maciej , Nagl Nathalie , Steinleitner Philipp , Karpowicz Nicholas , Pervak Vladimir , Głuszek Aleksander , Hudzikowski Arkadiusz , Krausz Ferenc , Mak Ka Fai , Weigel Alexander 
Published: May 2023

Single-cycle optical pulses with controllable carrier-envelope phase (CEP) form the basis to manipulate the nonlinear polarization of matter on a sub-femtosecond time scale. Moreover, nonlinear light–matter energy exchange and frequency conversion processes benefit from longer, infrared wavelengths. We report a highly stable source of 6.9-fs, single-cycle pulses at 2.2 µm, based on a directly diode-pumped Cr:ZnS oscillator with 22.9-MHz repetition rate. Extreme spectral broadening of the oscillator output to a super-octave bandwidth (1.1–3.1 µm) is achieved in a single rutile (TiO2) plate. Excellent agreement with simulations provides a precise understanding of the underlying nonlinear pulse propagation. A comprehensive investigation of alternative broadening materials and additional simulations single out the exceptional broadening in TiO2 due to the favorable interplay of self-focusing, and plasma formation accompanied by self-phase modulation and self-compression. Unprecedented reproducibility of the single-cycle waveforms is ensured by a unique combination of active CEP stabilization with a residual CEP jitter of only 5.9 mrad (0.1 Hz to 11.45 MHz) and a relative intensity noise of 0.036% (0.1 Hz to 1 MHz). The new single-cycle source permits efficient downconversion to the mid-infrared by cascaded intra-pulse difference frequency generation, giving access to sub-femtosecond manipulation of electric currents in low-bandgap materials with an unprecedented degree of control.
‘We do not rush to the hospital for ordinary wounds (suḷu tuvāla)’: A qualitative study on the early clinical manifestations of cutaneous leishmaniasis and associated health behaviours in rural Sri Lanka
Authors: Gunasekara Sonali Dinushika , Wickramasinghe Nuwan Darshana , Agampodi Suneth Buddhika , Fernando Manoj Sanjeewa , Weerakoon Kosala Gayan , Liyanage Chandani , Dikomitis Lisa , Agampodi Thilini Chanchala 
Published: May 2023

Background
Knowledge of early clinical manifestations, people’s perceptions and behaviours is crucial in preventing and controlling neglected tropical diseases (NTDs). Cutaneous leishmaniasis is an NTD that causes skin lesions and affects millions worldwide. Delayed healthcare-seeking behaviour leading to prolonged treatment periods and complications is rife among people with cutaneous leishmaniasis. This study examined the patient-reported early clinical manifestations of cutaneous leishmaniasis, local interpretations and associated health behaviours within the socio-cultural context of rural Sri Lanka.

Methodology/principal findings
We conducted a qualitative study among people with cutaneous leishmaniasis in three rural communities in the Anuradhapura district, Sri Lanka. Participants’ experiences were explored through a study-bespoke participant experience reflection journal and in-depth interviews. We analysed the data using a narrative-thematic approach. The study included 30 people with cutaneous leishmaniasis (12 females and 18 males) aged between 18 and 75 years. We identified four major themes during the analysis: 1) patient-reported early clinical manifestations of cutaneous leishmaniasis, 2) local interpretations of the early skin lesion(s), 3) associated actions and behaviours, and 4) the time gap between the initial notice of symptoms and seeking healthcare for cutaneous leishmaniasis. Early clinical manifestations differed among the participants, while the majority misinterpreted them as a mosquito/ant bite, pimple, wart, eczema, macule, or worm infestation. Participants undertook different context-specific self-management actions to cure cutaneous leishmaniasis. We identified an average time gap between the notice of symptoms and the first visit to the healthcare facility ranging from three to twelve months.

Conclusions/significance
Diverse early clinical manifestations, local interpretations, and associated behaviours of people with cutaneous leishmaniasis have led to a substantial delay in healthcare-seeking. The study sheds light on the importance of understanding the manifestations of NTDs within the social context. Our findings will inform designing context-specific health interventions to improve awareness and healthcare-seeking in cutaneous leishmaniasis in rural settings.
Relationship between self-management of patients with anxiety disorders and their anxiety level and quality of life: A cross-sectional study
Authors: Cao Xinyu , Feng Mei , Ge Ruyu , Wen Yan , Yang Jing , Li Xiaolin 
Published: May 2023

Purpose
To explore the correlation between self-management and anxiety and quality of life in patients with anxiety disorders and to understand whether self-management can influence the relationship between anxiety and quality of life and provide a basis for improving their anxiety and quality of life.

Methods
A cross-sectional survey of 245 patients with anxiety disorders in West China Hospital of Sichuan University was conducted using the Self-Management of Anxiety Disorders Scale, Self-rating anxiety scale (SAS), and World Health Organization Quality of Life-BBREF. The data were then analyzed using descriptive tests and Pearson correlation in SPSS 25. Bootstrap mediated effects tests were used to test the effect relationship between anxiety, quality of life and self-management scores in patients with anxiety disorders and Amos was used to establish the structural equation model.

Results
The results of the correlation analysis showed that the total self-management score was positively correlated with the total quality of life score (r = 0.695, P <0.001), physical domain score (r = 0.552, P <0.001), psychological domain score (r = 0.661, P <0.001), social relations domain score (r = 0.542, P <0.001), and environmental domain score (r = 0.614, P <0.001). Additionally, it was negatively correlated with SAS score (r = –0.470, P <0.001). Self-management partially mediates the relationship between anxiety and quality of life, and the direct effect value of anxiety on quality of life was –0.44. The indirect effect value of self-management was –0.27, accounting for 38% of the total effect value.

Conclusion
Self-management of patients with anxiety disorders was negatively correlated with anxiety and positively correlated with quality of life. It played a partially mediating effect between anxiety and quality of life. We recommend that healthcare providers pay attention to self-management interventions for patients with anxiety disorders to further improve their quality of life.
Impact of top metal electrodes on current conduction in WO3 thin films
Authors: Sharma Savita , Tomar Monika , Gulati Sudha 
Published: May 2023

Abstract
Using radio-frequency (rf) sputtering technique tungsten oxide (WO3) thin films (∼150 nm) were deposited in a gas mixture of Ar and O2 at 10 mTorr pressure on indium tin oxide (ITO) and corning glass substrates. The films were annealed at 400 °C. Structural and optical properties of films were studied. Metal–insulator–metal (MIM) structure was made by depositing metal electrode (Ag, Al, Au) on the prepared WO3 thin films (on ITO substrate) using thermal evaporation technique. Electrical properties of the MIM structure were studied by plotting current versus voltage (I–V) curves for Ag, Al and Au metal electrodes. Current conduction mechanism in WO3 film was determined by plotting and fitting I–V data in different equations of current mechanisms.
(Un)real City: Spatial and Temporal Ghosting in ANU Productions’ The Party to End All Parties
Authors: Radak Tamara 
Published: May 2023

Abstract
As COVID-19-related closures affected theatre and performance venues worldwide, the question of how theatrical practices might be adapted to these new circumstances became particularly pertinent in the context of immersive theatre and site-specific performance, forms which heavily draw on the audience’s experiential encounter with site and performers for its process of meaning-making. Focussing on ANU Productions’ The Party to End All Parties (2020) as a hybrid form of site-specific pandemic theatre set in the cityscape of Dublin, this article investigates how the production translated the “host/ghost” relationship as a central aspect of site-specific theatre to the virtual realm. It demonstrates how this notion is transformed into a thematic thread woven into the performance, arguing that it engages with the host/ghost relationship through spatial as well as temporal “ghosting,” which blurs the lines between the contemporary setting of lockdown Dublin and the historical landmark of O’Connell Bridge as a site inextricably connected to the emergence of Ireland as a republic. At the same time, this notion is explored through the connections between presence and absence, visibility and invisibility (or, indeed, spectrality) in the three characters’ personal journeys.
Bats (Mammalia, Chiroptera) and bat flies (Diptera, Streblidae) found in the largest sandstone cave of Brazil
Authors: Vieira Thiago Bernardi , Correia Letícia Lima , Pena Simone Almeida , Gomes-Almeida Brenda K. , Urbieta Gustavo Lima , Graciolli Gustavo , Palheta Leandra Rose , Caçador Antônio Wesley Barros , M S Aguiar Ludmilla 
Published: May 2023

Abstract
Bats provide essential ecosystem services and some are cave dependent. Caves favour the association of bats with ectoparasite Diptera, however, they are poorly sampled in the Amazon biome. Here we present the first description of a community of bats and bat flies from the largest sandstone cave in Brazil, the Planaltina cave, located in the municipality of Brasil Novo, state of Pará. Diptera were removed from captured bats and taken to the laboratory for identification. From nine species of bats belonging to four families we recorded 17 species of Diptera, 13 were monoxenous. A possible explanation for the monoxenous parasites collected is that flies have poor survival in unusual hosts. These results are an indicator that the Streblid species are host-specific since even if the hosts take refuge in the same cave, they will not share their parasites. Therefore, the present study provides important information on the parasite-host dynamics in a cave, thus highlighting the importance of cave as are essential shelters for bat species and, despite reported cases of cohabitation, mixed colonies are unlikely to form.
Simulation study and experimental validation of a neural network-based predictive tracking system for sensor-based sorting
Authors: Maier Georg , Reith-Braun Marcel , Bauer Albert , Gruna Robin , Pfaff Florian , Kruggel-Emden Harald , Längle Thomas , Hanebeck Uwe D. , Beyerer Jürgen 
Published: May 2023

Abstract
Sensor-based sorting offers cutting-edge solutions for separating granular materials. The line-scanning sensors currently in use in such systems only produce a single observation of each object and no data on its movement. According to recent studies, using an area-scan camera has the potential to reduce both characterization and separation error in a sorting process. A predictive tracking approach based on Kalman filters makes it possible to estimate the followed paths and parametrize a unique motion model for each object using a multiobject tracking system. While earlier studies concentrated on physically-motivated motion models, it has been demonstrated that novel machine learning techniques produce predictions that are more accurate. In this paper, we describe the creation of a predictive tracking system based on neural networks. The new algorithm is applied to an experimental sorting system and to a numerical model of the sorter. Although the new approach does not yet fully reach the achieved sorting quality of the existing approaches, it allows the use of the general method without requiring expert knowledge or a fundamental understanding of the parameterization of the particle motion model.
The Organization of Digital Platforms
Authors: Ametowobla Dzifa , Kirchner Stefan 
Published: May 2023

AbstractDigital platforms pervade contemporary societies, but sociology currently lacks a general concept for investigating them. Platforms combine technology and organizational elements in particular ways, but existing concepts consider these combinations in a one-sided manner: Business approaches focus on technological features solely in economic relationships, sociological approaches underestimate the relevance of technology for the multiple relationship forms. Extending on the understanding that all digital platforms share a core-periphery architecture, we develop the concept of platform organization for the many instances where this architecture enables and governs a social order through digital interfaces. Our paper contributes to a necessary debate on general concepts for sociological research that reconcile the role of technology with the social orders brought about by diverse digital platforms.
DeepRCI: predicting RNA‐chromatin interactions via deep learning with multi‐omics data
Authors: Xiong Yuanpeng , He Xuan , Zhao Dan , Jiang Tao , Zeng Jianyang 
Published: May 2023

Chromatin‐associated RNA (caRNA) acts as a ubiquitous epigenetic layer in eukaryotes, and has been reported to be essential in various biological processes. Here, we propose a highly interpretable computational framework, named DeepRCI, to identify the interactions between various types of RNAs and chromatin. DeepRCI can serve as a useful tool for characterizing RNA‐chromatin interactions and studying the underlying gene regulatory code.BackgroundChromatin‐associated RNA (caRNA) acts as a ubiquitous epigenetic layer in eukaryotes, and has been reported to be essential in various biological processes, including gene transcription, chromatin remodeling and cellular differentiation. Recently, numerous experimental techniques have been developed to characterize genome‐wide RNA‐chromatin interactions to understand their underlying biological functions. However, these experimental methods are generally expensive, time‐consuming, and limited in identifying all potential sites, while most of the existing computational methods are restricted to detecting only specific types of RNAs interacting with chromatin.MethodsHere, we propose a highly interpretable computational framework, named DeepRCI, to identify the interactions between various types of RNAs and chromatin. In this framework, we introduce a novel deep learning component called variformer and integrate multi‐omics data to capture intrinsic genomic features at both RNA and DNA levels.ResultsExtensive experiments demonstrate that DeepRCI can detect RNA‐chromatin interactions more accurately when compared to the state‐of‐the‐art baseline prediction methods. Furthermore, the sequence features extracted by DeepRCI can be well matched to known critical gene regulatory components, indicating that our model can provide useful biological insights into understanding the underlying mechanisms of RNA‐chromatin interactions. In addition, based on the prediction results, we further delineate the relationships between RNA‐chromatin interactions and cellular functions, including gene expression and the modulation of cell states.ConclusionsIn summary, DeepRCI can serve as a useful tool for characterizing RNA‐chromatin interactions and studying the underlying gene regulatory code.