bluuebunny/crossref_metadata_2025_split huggingface dataset:
Advanced cryopreservation engineering strategies: the critical step to utilize stem cell products
Authors: Wang Xiaohu , Wang Enyu , Zhao Gang 
Published: August 2023

AbstractWith the rapid development of stem cell-related therapies and regenerative medicine, the clinical application of stem cell products is on the rise. However, ensuring the effectiveness of these products after storage and transportation remains a challenge in the transformation to clinical trials. Cryopreservation technology allows for the long-term storage of cells while ensuring viability, making it a top priority for stem cell preservation. The field of cryopreservation-related engineering technologies is thriving, and this review provides an overview of the background and basic principles of cryopreservation. It then delves into the main bioengineering technologies and strategies used in cryopreservation, including photothermal and electromagnetic rewarming, microencapsulation, and synergetic ice inhibition. Finally, the current challenges and future prospects in the field of efficient cryopreservation of stem cells are summarized and discussed.
Rasch analysis of the Chinese version of the clinically useful depression outcome scale in patients with major depressive disorder
Authors: Zhong Jing , Ma Hai-Yan , Wang Xue-Mei , Huang Xiao-Jie , Xu Ming-Zhi 
Published: August 2023

Abstract
Objective
To examine the psychometric properties of the Chinese version of the Clinically Useful Depression Outcome Scale (CUDOS) in the Chinese patients with major depressive disorder (MDD) using Rasch analysis.

Methods
The sample consisted of 283 patients with MDD (69% females). The Rasch model was applied to examine the overall fit of the Chinese version of CUDOS and the fit of the 18 items. Dimensionality, item-model fit, differential item functioning (DIF), reliability, ordering of response category and targeting were tested to examine the psychometric properties of the Chinese version of CUDOS.

Results
Rasch analysis demonstrated the unidimensionality of the Chinese version of CUDOS. Of the 18 items, three items (item 4, item 5, item 6) showed misfit in the model. After merging item 4 into item 3 and item 6 into item 5, the overall model fit improved. The person separation index (PSI) was 3.0 and the person reliability coefficient was 0.90. No evidence of significant DIF was found when associated with gender and age. No disordered category and threshold of the rating response were observed, which meant the response category setting was reasonable. The mean ability of person was − 0.53.

Conclusion
The results suggested that the Chinese version of CUDOS has acceptable psychometric properties. In order to improve the quality and applicability of the Chinese version of CUDOS, the merging of item 4 into item 3 and item 6 into item 5 are suggested.
Prediction of broken areas in murals based on MLP-fused long-range semantics
Authors: Hu Nanyu , Wu Hao , Yuan Guowu 
Published: August 2023

Abstract
Predicting the broken areas in murals plays a key role in mural virtual restoration. Mural damage may arise for various reasons and the broken areas also vary greatly in terms of type. The existing methods, however, are limited to predicting a single type of damage and often struggle to identify the dispersed damage with accuracy. Moreover, these methods make it difficult to capture the global information in the broken areas for their insufficient understanding of contexts. To fully use the features at different scales, we propose a novel hierarchical multi-scale encoder-decoder framework termed as Mixer of Dual Attention and Convolution (DACMixer). With the introduction of an attention-convolution dual-branch module in the encoder, DACMixer can not only improve its ability to extract intricate features of small broken areas but also capture long-range dependencies of independent broken areas. Within DACMixer, the MFF (Multi-layer perceptron-based feature fusion) module integrates both local and global information in the broken areas, facilitating efficient and explicit modeling image hierarchies in the global and local range. Contrary to the encoder, DACMixer uses only lightweight multi-level decoder to decode the features of the broken masks, thus reducing the computational cost. Additionally, DACMixer preserves skip-connection to effectively integrate features from different levels of the MFF module. Furthermore, we provide a diversified mural dataset with elaborated broken annotation, which is named YMDA [YMDA denotes our dataset Yunnan_Murals_Dataset_Aug.], to further improve DACMixer’s generalization ability to predict the broken areas. The experimental results demonstrate that DACMixer is capable of predicting the texture, edges, and details of the broken areas in murals with complex backgrounds. DACMixer outperforms the conventional methods with superb results: it achieves 78.3% broken areas IoU (Intersection over Union), 87.5% MIoU (Mean Intersection over Union), and 85.7% Dice coefficient.
A study on the spatial distribution and historical evolution of grotto heritage: a case study of Gansu Province, China
Authors: Runze Yang 
Published: August 2023

Abstract
Grottoes are a comprehensive art treasure trove that integrate architecture, sculpture, and murals. They showcase the historical spiritual civilization of humanity and provide a solid foundation for studying the dissemination and development of Buddhist culture. Gansu Province is an important node on the transmission route of Buddhist culture, constituting a relatively complete and rich history of Buddhist art and cultural history. This article uses GIS technology to systematically analyse the spatial distribution characteristics and spatiotemporal evolution patterns of grottoes in Gansu Province from the Wei Jin to the Ming and Qing dynasties and explores the main factors affecting their distribution. The results indicate the following: (1) the grottoes in Gansu Province exhibit clustering and uneven distribution characteristics, which form the core aggregation area of Qingyang Tianshui City and the secondary aggregation area of Wuwei and Zhangye City. (2) Spatiotemporal characteristics show significant changes in the number and focus of excavation and repair of grottoes in Gansu Province over the years. The Northern and Southern Dynasties, Sui and Tang Dynasties, and Ming and Qing Dynasties had more grottoes than the Wei, Jin, and Yuan Dynasties. The overall centre of gravity shifted from northwest to southeast. Natural factors such as topography, stratigraphy, and hydrology and cultural factors such as politics and transportation significantly impacted the spatial pattern of grotto heritage in Gansu Province. Exploring and studying the spatial layout of grotto heritage from the perspective of historical geography is beneficial for understanding the cultural development and historical changes in Buddhism and is of great significance for the development of landscape environmental protection and utilization of grotto heritage.
AppChainer: investigating the chainability among payloads in android applications
Authors: Xiang Xiaobo , Jiang Yue , Guo Qingli , Zhang Xiu , Gong Xiaorui , Liu Baoxu 
Published: August 2023

AbstractStatistics show that more than 80 applications are installed on each android smartphone. Vulnerability research on Android applications is of critical importance. Recently, academic researchers mainly focus on single bug patterns, while few of them investigate the relations between multiple bugs. Industrial researchers proposed a series of logic exploit chains leveraging multiple logic bugs. However, there is no general model to evaluate the chaining abilities between bugs. This paper presents a formal model to elucidate the relations between multiple bugs in Android applications. To prove the effectiveness of the model, we design and implement a prototype system named AppChainer. AppChainer automatically identifies attack surfaces of Android applications and investigates whether the payloads entering these attack surfaces are “chainable”. Experimental results on 2138 popular Android applications show that AppChainer is effective in identifying and chaining attacker-controllable payloads. It identifies 14467 chainable payloads and constructs 5458 chains both inside a single application and among various applications. The time cost and resource consumption of AppChainer are also acceptable. For each application, the average analysis time is 317 s, and the average memory consumed is 2368 MB. Compared with the most relevant work Jandroid, the experiment results on our custom DroidChainBench show that AppChainer outperforms Jandroid at the precision rate and performs equally with Jandroid at the recall rate.
Staphylococcus xylosus and Staphylococcus aureus as commensals and pathogens on murine skin
Authors: Battaglia Michael , Garrett-Sinha Lee Ann 
Published: August 2023

AbstractSkin ulcers, skin dermatitis and skin infections are common phenomena in colonies of laboratory mice and are often found at increased prevalence in certain immunocompromised strains. While in many cases these skin conditions are mild, in other cases they can be severe and lead to animal morbidity. Furthermore, the presence of skin infections and ulcerations can complicate the interpretation of experimental protocols, including those examining immune cell activation. Bacterial species in the genus Staphylococcus are the most common pathogens recovered from skin lesions in mice. In particular, Staphylococcus aureus and Staphylococcus xylosus have both been implicated as pathogens on murine skin. Staphylococcus aureus is a well-known pathogen of human skin, but S. xylosus skin infections in humans have not been described, indicating that there is a species-specific difference in the ability of S. xylosus to serve as a skin pathogen. The aim of this review is to summarize studies that link S. aureus and S. xylosus to skin infections of mice and to describe factors involved in their adherence to tissue and their virulence. We discuss potential differences in mouse and human skin that might underlie the ability of S. xylosus to act as a pathogen on murine skin, but not human skin. Finally, we also describe mouse mutants that have shown increased susceptibility to skin infections with staphylococcal bacteria. These mutants point to pathways that are important in the control of commensal staphylococcal bacteria. The information here may be useful to researchers who are working with mouse strains that are prone to skin infections with staphylococcal bacteria.
Total knee arthroplasty in dialysis patients: a national in-patient sample-based study of perioperative complications
Authors: Venishetty Nikit , Wukich Dane K. , Beale Jack , Riley Martinez J. , Toutoungy Michel , Mounasamy Varatharaj , Sambandam Senthil 
Published: August 2023

Abstract
Background
Chronic kidney disease (CKD) is a growing disease that affects millions of people in the USA every year. Many CKD patients progress to end-stage renal disease (ESRD), necessitating the use of hemodialysis to alleviate symptoms and manage kidney function. Furthermore, many of these patients have lower bone quality and experience more postoperative complications. However, there is currently limited information on hospitalization information and perioperative complications in this population following procedures such as total knee arthroplasty (TKA). The purpose of this study was to assess the patient characteristics, demographics, and prevalence of postoperative problems among dialysis patients who received TKA.

Methods
In this retrospective study, we used the Nationwide Inpatient Sample (NIS) data from 2016 to 2019 to analyze the incidence of perioperative complications, length of stay (LOS), and the cost of care (COC) among patients undergoing TKA who were categorized as dialysis patients, compared with those who were not. Propensity matching was conducted to consider associated factors that may influence perioperative complications.

Results
From 2016 to 2019, 558,371 patients underwent TKAs, according to the National In-Sample (NIS) database. Of those, 418 patients (0.1%) were in the dialysis group, while the remaining 557,953 patients were included in the control group. The mean age of the dialysis group was 65.4 ± 9.8 years, and the mean age in the control group was 66.7 ± 9.5 years (p = 0.006). After propensity matching, dialysis group patients had a higher risk of receiving blood transfusions [odds ratio (OR): 2; 95% confidence interval (CI): 1.2, 3.4] and a significantly larger COC in comparison to those in the control group (91,434.3 USD versus 71,943.6 USD, p < 0.001). In addition, dialysis patients had significantly higher discharges to another facility, as compared with the control group patients.

Conclusions
The dialysis group had a significantly higher cost of care, higher rates of requiring blood transfusion, and more cases of being discharged to another facility than non-dialysis patients. This data will help providers make informed decisions about patient care and resource allocation for dialysis patients undergoing TKA.
A Systematic Review and Meta-Analysis of Interventions to Promote Adjuvant Endocrine Therapy Adherence Among Breast Cancer Survivors
Authors: Bright Emma E. , Finkelstein Lauren B. , Nealis Madeline S. , Genung Sarah R. , Wrigley Jordan , Gu Heng Chao J. , Schmiege Sarah J. , Arch Joanna J. 
Published: August 2023

PURPOSE Adjuvant endocrine therapy (AET) adherence among breast cancer survivors is often suboptimal, leading to higher cancer recurrence and mortality. Intervention studies to promote AET adherence have burgeoned, more than doubling in number since this literature was last reviewed. The current aim is to provide an up-to-date systematic review and meta-analysis of interventions to enhance AET adherence and to identify strengths and limitations of existing interventions to inform future research and clinical care. METHODS Systematic searches were conducted in three electronic databases. Studies were included in the systematic review if they examined an intervention for promoting AET adherence among breast cancer survivors. Studies were further included in the meta-analyses if they examined a measure of AET adherence (defined as compliance or persistence beyond initiation) and reported (or provided upon request) sufficient information to calculate an effect size. RESULTS Of 5,045 unique records, 33 unique studies representing 375,951 women met inclusion criteria for the systematic review. Interventions that educated patients about how to manage side effects generally failed to improve AET adherence, whereas policy changes that lowered AET costs consistently improved adherence. Medication reminders, communication, and psychological/coping strategies showed varied efficacy. Of the 33 studies that met the inclusion criteria for the systematic review, 25 studies representing 367,873 women met inclusion criteria for the meta-analysis. The meta-analysis showed statistically significant effects of the adherence interventions overall relative to study-specified control conditions (number of studies [k] = 25; odds ratio, 1.412; 95% CI, 1.183 to 1.682; P = .0001). Subgroup analyses showed that there were no statistically significant differences in effect sizes by study design (randomized controlled trial v other), publication year, directionality of the intervention (unidirectional v bidirectional contact), or intervention type. CONCLUSION To our knowledge, this is the first known meta-analysis to demonstrate a significant effect for interventions to promote AET adherence. The systematic review revealed that lowering medication costs and a subgroup of psychosocial and reminder interventions showed the most promise, informing future research, policy, and clinical directions.
Long-Term Consequences of Cushing Syndrome: A Systematic Literature Review
Authors: Puglisi Soraya , Perini Anna Maria Elena , Botto Cristina , Oliva Francesco , Terzolo Massimo 
Published: August 2023

Abstract
It is held that the condition of endogenous chronic hypersecretion of cortisol (Cushing syndrome, CS), causes several comorbidities, including cardiovascular and metabolic disorders, musculoskeletal alterations, as well as cognitive and mood impairment. Therefore, CS has an adverse impact on the quality of life and life expectancy of affected patients. What remains unclear is whether disease remission may induce a normalization of the associated comorbid conditions. In order to retrieve updated information on this issue, we conducted a systematic search using the Pubmed and Embase databases to identify scientific papers published from January 1, 2000, to December 31, 2022. The initial search identified 1907 potentially eligible records. Papers were screened for eligibility and a total of 79 were included and classified by the main topic (cardiometabolic risk, thromboembolic disease, bone impairment, muscle damage, mood disturbances and quality of life, cognitive impairment, and mortality).
Although the limited patient numbers in many studies preclude definitive conclusions, most recent evidence supports the persistence of increased morbidity and mortality even after long-term remission. It is conceivable that the degree of normalization of the associated comorbid conditions depends on individual factors and characteristics of the conditions. These findings highlight the need for early recognition and effective management of patients with CS, which should include active treatment of the related comorbid conditions. In addition, it is important to maintain a surveillance strategy in all patients with CS, even many years after disease remission, and to actively pursue specific treatment of comorbid conditions beyond cortisol normalization.
Variability in the Arterial Supply of Intracranial Meningiomas: An Anatomic Study
Authors: Ahmed Abdul-Kareem , Wilhelmy Bradley , Oliver Jeffrey , Serra Riccardo , Chen Chixiang , Gandhi Dheeraj , Eisenberg Howard M. , Labib Mohamed A. , Woodworth Graeme F. 
Published: August 2023

BACKGROUND AND OBJECTIVES:
Intracranial meningiomas are a diverse group of tumors, which vary by grade, genetic composition, location, and vasculature. Expanding the understanding of the supply of skull base (SBMs) and non–skull base meningiomas (NSBMs) will serve to further inform resection strategies. We sought to delineate the vascular supply of a series of intracranial meningiomas by tumor location.

METHODS:
A retrospective study of intracranial meningiomas that were studied using preoperative digital subtraction angiograms before surgical resection at a tertiary referral center was performed. Patient, tumor, radiologic, and treatment data were collected, and regression models were developed.

RESULTS:
One hundred sixty-five patients met inclusion criteria. The mean age was 57.1 years (SD: 12.6). The mean tumor diameter was 4.9 cm (SD: 1.5). One hundred twenty-six were World Health Organization Grade I, 37 Grade II, and 2 Grade III. Arterial feeders were tabulated by Al-Mefty's anatomic designations. SBMs were more likely to derive arterial supply from the anterior circulation, whereas NSBMs were supplied by external carotid branches. NSBMs were larger (5.61 cm vs 4.45 cm, P = <.001), were more often presented with seizure (20% vs 8%, P = .03), were higher grade (P = <.001) had more frequent peritumoral brain edema (84.6% vs 66%, P = .04), and had more bilateral feeders (47.7% vs 28%, P = .01) compared with SBMs. More arterial feeders were significantly associated with lower tumor grade (P = .023, OR = 0.59). Higher tumor grade (Grade II/III) was associated with fewer arterial feeders (P = .017, RR = 0.74).

CONCLUSION:
Meningioma location is associated with specific vascular supply patterns, grade, and patient outcomes. This information suggests that grade I tumors, especially larger tumors, are more likely to have diverse vascular supply patterns, including internal carotid branches. This study may inform preoperative embolization and surgical considerations, particularly for large skull base tumors.
Basement membrane dynamics and mechanics in tissue morphogenesis
Authors: Töpfer Uwe 
Published: August 2023

ABSTRACT
The basement membrane (BM) is a thin, planar-organized extracellular matrix that underlies epithelia and surrounds most organs. During development, the BM is highly dynamic and simultaneously provides mechanical properties that stabilize tissue structure and shape organs. Moreover, it is important for cell polarity, cell migration, and cell signaling. Thereby BM diverges regarding molecular composition, structure, and modes of assembly. Different BM organization leads to various physical features. The mechanisms that regulate BM composition and structure and how this affects mechanical properties are not fully understood. Recent studies show that precise control of BM deposition or degradation can result in BMs with locally different protein densities, compositions, thicknesses, or polarization. Such heterogeneous matrices can induce temporospatial force anisotropy and enable tissue sculpting. In this Review, I address recent findings that provide new perspectives on the role of the BM in morphogenesis.
Stress in the social context: a behavioural and eco-evolutionary perspective
Authors: MacLeod Kirsty J. , English Sinead , Ruuskanen Suvi K. , Taborsky Barbara 
Published: August 2023

ABSTRACTThe social environment is one of the primary sources of challenging stimuli that can induce a stress response in animals. It comprises both short-term and stable interactions among conspecifics (including unrelated individuals, mates, potential mates and kin). Social stress is of unique interest in the field of stress research because (1) the social domain is arguably the most complex and fluctuating component of an animal's environment; (2) stress is socially transmissible; and (3) stress can be buffered by social partners. Thus, social interactions can be both the cause and cure of stress. Here, we review the history of social stress research, and discuss social stressors and their effects on organisms across early life and adulthood. We also consider cross-generational effects. We discuss the physiological mechanisms underpinning social stressors and stress responses, as well as the potential adaptive value of responses to social stressors. Finally, we identify outstanding challenges in social stress research, and propose a framework for addressing these in future work.
Nuclear Magnetic Resonance Study on Relationship between Phase Behavior and Rotational and Translational Dynamics of an Ionic Liquid with a Plastic Crystal Phase: N-Butyl-N-methylpiperidinium Hexafluorophosphate
Authors: Nishikawa Keiko , Fujii Kozo 
Published: August 2023

Abstract
N-butyl-N-methylpiperidinium hexafluorophosphate, [C1C4pip]PF6, is an ionic liquid with a plastic crystal (PC) phase. To investigate the dynamics of the phase transition between crystalline, plastic crystalline, and liquid phases of [C1C4pip]PF6, we measured the temperature dependences of longitudinal and transverse relaxation times (T1 and T2, respectively) for 1H and 19F using low-frequency pulse nuclear magnetic resonance (NMR) methods. T1 and T2 changes are sensitive to the rotational and translational dynamics of ions, respectively. Since H and F atoms are only present in the cation and anion, respectively, the dynamic behaviors of each ionic molecule can be investigated separately. In the phase transition between the PC and liquid phase, the temperature-dependent curves of 1H-T1 were smoothly connected, indicating the same rotational motion for the cation occurred in both phases. The curves of 19F-T1 yielded the same conclusion for the rotational motion of the anion in both phases. The temperature-dependent curves of 1H-T2 and 19F-T2 jumped abruptly from phase to phase, indicating different modes of translational motion in each phase. We observed the appearance of a translationally mobile component in both the PC phase and the crystalline phase. This was concluded to be surface or interfacial melting.