bluuebunny/crossref_metadata_2025_split huggingface dataset:
Early Risk Stratification for Natural Disease Course in Fabry Patients Using Plasma Globotriaosylsphingosine Levels
Authors: van der Veen Sanne J. , Sayed Mohamed el , Hollak Carla E.M. , Brands Marion M. , Snelder C. Khya S. , Boekholdt S. Matthijs , Vogt Liffert , Goorden Susan M.I. , van Kuilenburg André B.P. , Langeveld Mirjam 
Published: July 2023

Background
Fabry disease is a very heterogeneous X-linked lysosomal storage disease. Disease manifestations in the kidneys, heart, and brain vary greatly, even between patients of the same sex and with the same disease classification (classical or nonclassical). A biomarker with a strong association with the development of disease manifestations is needed to determine the need for Fabry-specific treatment and appropriate frequency of follow-up because clinical manifestations of the disorder may take decennia to develop.

Methods
We investigated the levels of plasma lysoGb3 levels over time and its association with disease manifestations and disease course in 237 untreated patients with Fabry disease (median age 42 years, 38% male) using linear mixed-effect models.

Results
LysoGb3 levels are stable over time in plasma of untreated patients with Fabry disease. Higher levels of lysoGb3 were associated with steeper decline in eGFR (P = 0.05) and a faster increase in albuminuria (measured as the urinary albumin-to-creatinine ratio, P < 0.001), left ventricular mass (measured on echocardiography, P < 0.001), left atrial volume index (P = 0.003), and Fazekas score (P = 0.003). In addition, regardless of age, higher lysoGb3 levels were associated with higher relative wall thickness (P < 0.001) and unfavorable functional markers on echocardiography, including septal mitral annular early diastolic velocity (e′, P < 0.001) and the ratio of early transmitral velocity (E) to e′ (E/e′, P = 0.001).

Conclusions
In an individual patient with Fabry disease, the plasma lysoGb3 level reached a specific level in early childhood which, in the absence of Fabry-specific treatment, remained stable throughout life. The level of lysoGb3 in untreated patients was associated with nearly all Fabry-specific disease manifestations, regardless of the sex of the patient.
Epidemiological and clinical aspects of congenital heart disease in Fallujah Maternity and Children Hospital, Iraq
Authors: Alaani Samira Telfah Abdilghani , Alkubaisy Firas Sadiq , Merie Abdulqadir Abdulkareem 
Published: July 2023

Objective: This study aimed to analyze the descriptive characteristics of children diagnosed with Congenital Heart Disease (CHD) at Fallujah Maternity and Children Hospital (FMCH).
Methods: The prospective study included 1,025 pediatric patients born between 1st December 2018 and 30th September 2022, admitted to the newborns and children's wards, and diagnosed with CHD. Data were collected through interviews with patients' guardians using a registration and questionnaire form, capturing variables related to the child (e.g., name, sex, birth weight, type of CHD) and the mother (e.g., age, occupation, consanguinity, previous CHD births, chronic diseases during pregnancy). Residence (rural or urban) was also recorded.
Results: Among the CHD cases, Atrial Septal Defect (ASD) was the most common (72%), followed by Ventricular Septal Defect (VSD) (25%) and Patent Ductus Arteriosus (PDA) (21%). Most diagnoses occurred in children aged 1-28 days. The male-to-female ratio was 1.2:1, and 0.2% had an ambiguous gender. About 58% of children weighed ≥ 2.5kg at birth, and 20% had a family history of CHDs.
Conclusion: The increasing prevalence of congenital heart diseases in Fallujah requires preventive strategies targeting modifiable risk factors, better monitoring of high-risk pregnancies, and increased awareness of genetic counseling for families with congenital anomalies. The cardiology department should receive more attention and resources to improve diagnostic and therapeutic capabilities. Further research is needed to understand the reasons behind the recent rise in CHD cases in newborns.
Does clinical experience affect the bracket bonding accuracy of guided bonding devices in vitro?
Authors: Li Bin , Wang Peiqi , Zheng Qinghua , Huang Lixuan , Hu Siyuan , Han Xianglong , Bai Ding , Xue Chaoran 
Published: July 2023

ABSTRACT

Objectives
To study whether and how the clinical experience of the operator affects the accuracy of bracket placement using guided bonding devices (GBDs) in vitro.

Materials and Methods
Five resin models were bonded virtually with brackets, and the corresponding GBDs were generated and three-dimensionally printed. Nine operators, which included three dental students, three orthodontic students, and three orthodontists, bonded the brackets on the resin models using GBDs on a dental mannequin. After being bonded with brackets, the models were scanned, and the actual and designed positions of the brackets were compared.

Results
There was no immediate debonding. The orthodontists spent a significantly shorter time (22.36 minutes) in bracket bonding than the dental students (24.62 minutes; P &lt; .05). The brackets tended to deviate to the buccal side in the dental student group. Linear deviations tended to be smallest in the orthodontic student group, but no significant difference was found among operators with different clinical experience (P &gt; .5). All linear and angular deviations in each group were under 0.5 mm and 2°, respectively.

Conclusions
Clinical experience was positively related to the bonding accuracy using GBDs, especially in the buccolingual dimension. Inexperience also led to longer bonding duration. However, bonding accuracy was clinically acceptable in general.
AMPKγ3 Controls Muscle Glucose Uptake in Recovery From Exercise to Recapture Energy Stores
Authors: Kido Kohei , Eskesen Nicolas O. , Henriksen Nicolai S. , Onslev Johan , Kristensen Jonas M. , Larsen Magnus R. , Hingst Janne R. , Knudsen Jonas R. , Birk Jesper B. , Andersen Nicoline R. , Jensen Thomas E. , Pehmøller Christian , Wojtaszewski Jørgen F.P. , Kjøbsted Rasmus 
Published: July 2023

Exercise increases muscle glucose uptake independently of insulin signaling and represents a cornerstone for the prevention of metabolic disorders. Pharmacological activation of the exercise-responsive AMPK in skeletal muscle has been proven successful as a therapeutic approach to treat metabolic disorders by improving glucose homeostasis through the regulation of muscle glucose uptake. However, conflicting observations cloud the proposed role of AMPK as a necessary regulator of muscle glucose uptake during exercise. We show that glucose uptake increases in human skeletal muscle in the absence of AMPK activation during exercise and that exercise-stimulated AMPKγ3 activity strongly correlates to muscle glucose uptake in the postexercise period. In AMPKγ3-deficient mice, muscle glucose uptake is normally regulated during exercise and contractions but impaired in the recovery period from these stimuli. Impaired glucose uptake in recovery from exercise and contractions is associated with a lower glucose extraction, which can be explained by a diminished permeability to glucose and abundance of GLUT4 at the muscle plasma membrane. As a result, AMPKγ3 deficiency impairs muscle glycogen resynthesis following exercise. These results identify a physiological function of the AMPKγ3 complex in human and rodent skeletal muscle that regulates glucose uptake in recovery from exercise to recapture muscle energy stores.

Article Highlights
Exercise-induced activation of AMPK in skeletal muscle has been proposed to regulate muscle glucose uptake in recovery from exercise. This study investigated whether the muscle-specific AMPKγ3-associated heterotrimeric complex was involved in regulating muscle glucose metabolism in recovery from exercise. The findings support that exercise-induced activation of the AMPKγ3 complex in human and mouse skeletal muscle enhances glucose uptake in recovery from exercise via increased translocation of GLUT4 to the plasma membrane. This work uncovers the physiological role of the AMPKγ3 complex in regulating muscle glucose uptake that favors replenishment of the muscle cellular energy stores.
Type 1 Diabetes Genetic Risk Score Differentiates Subgroups of Ketosis-Prone Diabetes
Authors: Osafehinti Deborah , Mulukutla Surya N. , Hampe Christiane S. , Gaba Ruchi , Ram Nalini , Weedon Michael N. , Oram Richard A. , Balasubramanyam Ashok 
Published: July 2023

OBJECTIVE
To determine whether genetic risk for type 1 diabetes (T1D) differentiates the four Aβ subgroups of ketosis-prone diabetes (KPD), where A+ and A− define the presence or absence of islet autoantibodies and β+ and β− define the presence or absence of β-cell function.

RESEARCH DESIGN AND METHODS
We compared T1D genetic risk scores (GRS) of patients with KPD across subgroups, race/ethnicity, β-cell function, and glycemia.

RESULTS
Among 426 patients with KPD (54% Hispanic, 31% African American, 11% White), rank order of GRS was A+β− &gt; A+β+ = A−β− &gt; A−β+. GRS of A+β− KPD was lower than that of a T1D cohort, and GRS of A−β+ KPD was higher than that of a type 2 diabetes cohort. GRS was lowest among African American patients, with a similar distribution across KPD subgroups.

CONCLUSIONS
T1D genetic risk delineates etiologic differences among KPD subgroups. Patients with A+β− KPD have the highest and those with A−β+ KPD the lowest GRS.
Restoration of a Microdont Using the Resin Composite Injection Technique With a Fully Digital Workflow: A Flexible 3D-printed Index With a Stabilization Holder
Authors: Watanabe K , Tichy A , Kamoi K , Hiasa M , Yonekura K , Tanaka E , Nakajima M , Hosaka K 
Published: July 2023

SUMMARY
Direct composite restorations are accepted as a treatment option for microdontia, which is a relatively prevalent condition that poses esthetic concerns. While free-hand composite placement is technique-sensitive and time-consuming, the resin composite injection technique is more straightforward and predictable. A fully digital workflow has been recently introduced, but the 3D-printed resin index is rigid and challenged by undercuts, as opposed to the silicone index. This case report presents a flexible 3D-printed resin index, which can accurately transfer the digitally simulated functional and esthetic form to the final restoration. In addition, a rigid stabilization holder was designed to stabilize the flexible index.
Particular Clinical Manifestation of the Pain Syndrome in Canine Acute Gastroenteritis
Authors: Kuprina E. A. , Rudenko A. A. , Lutsai V. I. , Rudenko P. A. 
Published: July 2023

Introduction. Gastroenteritis is a widespread canine pathology often complicated with the pain syndrome and characterized by development of intoxication, dehydration, haemoconcentration and such inflammatory reaction as the neutrophilic left shift leukocytosis. The aim of the work is to provide a clinical description of the canine acute gastroenteritis dependingon the pain syndrome presence and severity degree.Materials and Methods. 31 dogs sick with acute gastroenteritis were studied, they were divided into 2 subgroups: the first (n=14) – animals with the acute gastroenteritis not complicated with the pain syndrome; the second (n=17) – animals with the acute gastroenteritis complicated with the pain syndrome.Results. In dogs with acute gastroenteritis, the depression or anxiety, vomiting, diarrhea, subfebrile fever, abdominal wall tenderness on palpation, decreased skin turgor, moderate tachycardia and tachypnea were observed. When analyzing the clinical and anamnestic data, it was found that before the symptoms emerged, 65% of the animals had consumed the poor-quality or rough feed (bones). In 35% of cases, the reason of acute gastroenteritis could not be detected. Contamination and increased growth of opportunistic pathogens in the gastrointestinal tract cause the development of intoxication, dehydration and systemic inflammatory syndrome. Alimentary gastroenteritis in 54.8% of sick dogs is complicated with the acute pain syndrome, which is a predictor of the disease severity degree.Discussion and Conclusions. In dogs with acute gastroenteritis complicated with the pain syndrome, the severe tachycardia and tachypnea get developed, the number of erythrocytes, leukocytes, band and segmented neutrophils, erythrocyte sedimentation rate and hematocrit in the blood significantly increase. The perspective for the further research is foreseen in the development and clinical testing of the multimodal analgesia methods in animals with the inflammatory gastrointestinal diseases.
Efficacy of Bimectin® Anthelminthic against Helminthiasis in Horses in the Tyumen Region Conditions
Authors: Kalugina E. G. , Stolbova O. A. 
Published: July 2023

Introduction. Helminthic infestation in horses is one of the most important problems the veterinary specialists face today, because helminth end-products affect significantly the overall condition of animals. The weight loss, depression, impaired work capacity, deterioration of stamina, exterior characteristics and natural resistance are observed and all together create the favourable conditions for arising the diseases of various etiology and cause considerable damage to horse breeding industry. The aim of the research is to determine the therapeutic efficacy of the anthelminthic drug «Bimectin®» against the intestinal helminthiasis in horses in the Tyumen region conditions.Materials and Methods. The studies were carried out with regard to the clinical examinations of animals and in compliance with the generally accepted parasitological methods. The infestation intensity (II), extensive efficacy (EE) and intensive efficacy (IE) were assessed, the haematological and biochemical blood tests were made on the 7th and 14th day before and after applying the drug. The results were statistically processed using the Statistica 6.1 software.Results. When assessing the therapeutic efficacy, we have determined that at a single application in the dose of 1.13 g. per 100 kg. of animal weight, the anthelminthic drug «Bimectin®» turned out to be 100 % therapeutically efficient and well tolerated by horses infested with Oxyuris equi and suborder Strongylata helminths, 91.7 % efficient against Parascaris equorum and 83.3 % efficient against Strongyloides westeri helminths.Discussion and Conclusions. Thus, in the result of assessing the therapeutic efficacy of the anthelmintic drug «Bimectin» against the horse helminthiasis, its economic benefit for using at the horse breeding farms of the region was confirmed, which should be taken into account when planning the combat measures against the nematode infestation in horses.
Exploring mathematical technological knowledge of teachers with Geogebra application
Authors: Ma'rufi Ma'rufi , Ilyas Muhammad , Ikram Muhammad , Seti Sirikanya 
Published: July 2023

Geogebra is a mathematical software that can be used in mathematics, especially geometry, calculus, and dynamic algebra, with various features, especially visualization. Geogebra helps students identify and improve their visual skills in understanding mathematical concepts. This study aims to explore the mathematical technology knowledge of teachers based on Geo-Gebra applications in mathematics learning by integrating content and technology. This research is qualitative research that uses a single-case design to explore the teacher's mathematical technology knowledge and involved teachers (N = 8) from the field of mathematics at universities in the Central Region of Indonesia. Three types of data were collected during one semester, weekly observations, progress report description; and the developed learning design. This research shows that there are two categories of teachers' mathematical technology knowledge characteristics. First, moderate teachers produce simple designs and are still influ-enced by numerical and algebraic approaches. Second, expert teachers can use analytical skills to design step-by-step learning, involving animation to explain concepts, and the resulting designs are quite complex and structured. These two findings are useful for building teacher competencies regarding using GeoGebra ap-plication-based technology in learning mathematics.
Design, fabrication, and evaluation of 3-D–printed cystotomy spoons as a retrieval method in dogs
Authors: D'Angelo Davina C. , Stephens Sam E. , Jensen Morten O. , Thomas Lauren R. 
Published: July 2023

Abstract

OBJECTIVE
Current cystotomy methods often implement the use of off-label devices, resulting in urocystolith extraction difficulty and potentially leading to postoperative complications and discomfort for the patient. The objective of this study was to create 3 novel 3-D printed cystotomy spoons that offer a dedicated solution for removing urocystoliths from a patient's urinary bladder.

ANIMALS
Clinical use of the 3 novel 3-D printed cystotomy spoons were ultimately evaluated in 4 dogs and 1 cat that presented for urocystotlith removal at 3 different veterinary hospitals in northwest Arkansas.

METHODS
The novel cystotomy spoons were designed using SolidWorks, 3-D printed with a Dental Surgical Guide resin, and underwent prototype testing that included chlorhexidine soaking, autoclave sterilization, 3-point bend testing, and Finite Element Analysis. The efficiency of the spoons was then evaluated through a limited proof-of-concept study utilizing a postoperative questionnaire for the participating clinicians.

RESULTS
Practitioner feedback indicated positive experiences using 1 or more of the novel 3-D printed cystotomy spoons while performing a cystotomy surgery. However, successful use of the spoons was ultimately limited to dogs in the 23 to 34 kg weight range.

CLINICAL RELEVANCE
Novel 3-D printed cystotomy spoons have the potential to mediate urocystolith extraction difficulty and reduce postoperative complications. Additionally, this research demonstrates how veterinarians might develop custom 3-D models and prints to meet patient-specific needs. As such, further development could impact the standard of healthcare and the veterinary industry by promoting the use of additive manufacturing in veterinary medicine.
Current distribution and modeling of potential distribution ofElodea nuttallii(Planch.) H. St. John at the territory of Ukraine and Europe
Authors: Prokopuk Mariana , Holiaka Dmytrii , Zub Lesya 
Published: July 2023

AbstractElodea nuttallii(Planch.) H. St. John – an invasive species that actively expands the boundaries of its secondary range. This work presents the current and predicted future distribution ofE. nuttalliiin Europe. The spread of the species is observed in northern areas with a mild oceanic climate (with mild winters and cool, rainy summers) formed by Atlantic cyclones.E. nuttalliioccurs in aquatic biotopes throughout the temperate climatic zone and partially occurs in the subtropical. It was established that the most important factors in determining the possibility of a plant’s spread are the amount of precipitation in the driest month, the minimum temperature of the coldest month, and altitude above the sea level. According to the data collected, the species is at its ecological optimum in most of Europe. Most of the changes expected in the next 100 years will take place in the next 30–40 years.
Wachstumsunabhängigkeit: Transformation und Wohlstand erneuern – ohne Wachstum
Authors: Kurz Rudi 
Published: July 2023

Abstract
Radically changed global conditions are forcing a “Great Transformation” of the economy and society. Predominantly, this is understood as a modernisation process associated with massive investments and a surge in (green) growth. However, the likelihood of such a scenario is fading and it seems necessary to invest more research activity and more political attention in alternative scenarios. The resilience of the economic and social order will depend on whether it is possible to establish a prosperity perspective that is independent of growth. With “Renewing Prosperity,” the German Federal Ministry of Economic Affairs and Climate Action has presented some building blocks that can be part of a strategic reorientation.
Wohlstand neu denken und messen
Authors: Dirksen Jakob , de Miranda Katharina Lima 
Published: July 2023

Abstract
Addressing the major challenges Germany and the world face today – from mitigating climate change to the shortage of skilled labor – will require concerted, transformative political effort that builds on collective values and pursues societal goals. Economic growth should be achieved in a sustainable and inclusive manner and not at the expense of social cohesion or future generations. To do this, we need to rethink prosperity and find new ways to measure it. Productivity growth and material gains, measured in terms of gross domestic product (GDP), are important, but insufficient as central targets and yardsticks for social progress. The things that we actually value should be measured. This includes not only economic well-being and income distribution, but also other dimensions of well-being, such as social participation, societal cohesion, personal empowerment and opportunity, as well as environmental sustainability. In this article, we discuss Germany’s strategy for measuring and improving multidimensional, sustainable prosperity, and propose ways to rethink and design new measures of economic and social prosperity that encompass not only material prosperity and economic output, but also the social and environmental dimensions of prosperity.
Force Projection in the Time of Scurvy: The Destruction of the 1740-42 West Indies Expedition
Authors: Chapman Craig S. 
Published: July 2023

The massive British West Indies expedition of 1740-42 during the War of Jenkins’ Ear, launched with an ambitious goal, produced nothing beyond terrible losses. The enormous number of deaths from yellow fever has obscured the true reasons for the defeat at Cartagena de Indias that has often been blamed on the army’s slow siege tactics. The author, following his research for Disaster on the Spanish Main: The Tragic British American Expedition to the West Indies during the War of Jenkins’ Ear, has further developed evidence from British musters that upends common assumptions about yellow fever’s impact and, instead, traces the cause of the expedition’s failure to poor health management and misguided military leadership.
L'expédition massive des Antilles britanniques de 1740-1742 pendant la guerre de l'Oreille de Jenkins, lancée avec un objectif ambitieux, n'a rien produit d'autre que de pertes terribles. Le nombre énorme de décès dus à la fièvre jaune obscurcit les véritables raisons de la défaite à Carthagène des Indes, souvent imputée à la lenteur des tactiques de siège de l'armée. L'auteur, suite à ses recherches pour Disaster on the Spanish Main: The Tragic British American Expedition to the West Indies during the War of Jenkins’ Ear, a étudié en profondeur les données probantes issues des registre militaire britanniques pour réfuter les hypothèses courantes sur l'impact de la fièvre jaune et attribuer plutôt l'échec de l'expédition à une mauvaise gestion de la santé et à un leadership militaire peu judicieux.