bluuebunny/crossref_metadata_2025_split huggingface dataset:
The link between the sphingolipid rheostat and obstructive sleep apnea
Authors: Horváth Péter , Büdi Lilla , Hammer Dániel , Varga Rita , Losonczy György , Tárnoki Ádám Domonkos , Tárnoki Dávid László , Mészáros Martina , Bikov András 
Published: May 2023

AbstractChronic inflammation induced by hypoxia during sleep is an important mechanism of microvascular damage in OSA patients. In this study, we investigated the role of the sphingosine rheostat, which has diverse inflammatory effects. Thirty-seven healthy subjects and 31 patients with OSA were recruited. We collected data on demographics and comorbidities. Plasma sphingosine-1-phosphate and ceramide antibody concentrations were measured by ELISA. The results were compared between the OSA and control groups, and the correlations between these measurements and markers of disease severity and comorbidities were explored. Ceramide antibody levels were significantly elevated in OSA patients (892.17 ng/ml) vs. controls (209.55 ng/ml). S1P levels were also significantly higher in patients with OSA (1760.0 pg/ml) than in controls (290.35 pg/ml, p < 0.001). The ceramide antibody concentration showed correlations with BMI (ρ = 0.25, p = 0.04), CRP (ρ = 0.36, p = 0.005), AHI (ρ = 0.43, p < 0.001), ODI (ρ = 0.43, p < 0.001), TST90% (ρ = 0.35, p = 0.004) and the lowest oxygen saturation (ρ =  0.37, p = 0.001) in the whole study population but not when patients with OSA were analyzed separately. The elevated ceramide antibody and sphingosine-1-phosphate concentrations in patients suffering from OSA suggests their involvement in the pathomechanism of OSA and its comorbidities.
GIS-based calculation method of surge height generated by three-dimensional landslide
Authors: Yu Guo , Zhou Xiaowen , Bu Lei , Wang Chengfeng , Farooq Asim 
Published: May 2023

AbstractCombined with the spatial data processing capability of the Geographic Information Systems (GIS), the Pan Jiazheng method is extended from two-dimensional (2D) to three-dimensional (3D), and a 3D landslide surge height calculation method is proposed based on grid column units. First, the data related to the landslide are rasterized to form grid columns, and a force analysis model of 3D landslides is established. Combining the vertical strip method with Newton's laws of motion, dynamic equilibrium equations are established to solve the surge height. Moreover, a 3D landslide surge height calculation expansion module is developed in the GIS environment, and the results are compared with those of the 2D Pan Jiazheng method. Comparisons showed that the maximum surge height obtained by the proposed method is 24.6% larger than that based on the Pan Jiazheng method. Compared with the traditional 2D method, the 3D method proposed in this paper better represent the actual spatial state of the landslide and is more suitable for risk assessment.
3-Phosphoinositide-dependent kinase 1 drives acquired resistance to osimertinib
Authors: Meraz Ismail M. , Majidi Mourad , Fang Bingliang , Meng Feng , Gao Lihui , Shao RuPing , Song Renduo , Li Feng , Lissanu Yonathan , Chen Huiqin , Ha Min Jin , Wang Qi , Wang Jing , Shpall Elizabeth , Jung Sung Yun , Haderk Franziska , Gui Philippe , Riess Jonathan Wesley , Olivas Victor , Bivona Trever G. , Roth Jack A. 
Published: May 2023

AbstractOsimertinib sensitive and resistant NSCLC NCI-H1975 clones are used to model osimertinib acquired resistance in humanized and non-humanized mice and delineate potential resistance mechanisms. No new EGFR mutations or loss of the EGFR T790M mutation are found in resistant clones. Resistant tumors grown under continuous osimertinib pressure both in humanized and non-humanized mice show aggressive tumor regrowth which is significantly less sensitive to osimertinib as compared with parental tumors. 3-phosphoinositide-dependent kinase 1 (PDK1) is identified as a potential driver of osimertinib acquired resistance, and its selective inhibition by BX795 and CRISPR gene knock out, sensitizes resistant clones. In-vivo inhibition of PDK1 enhances the osimertinib sensitivity against osimertinib resistant xenograft and a patient derived xenograft (PDX) tumors. PDK1 knock-out dysregulates PI3K/Akt/mTOR signaling, promotes cell cycle arrest at the G1 phase. Yes-associated protein (YAP) and active-YAP are upregulated in resistant tumors, and PDK1 knock-out inhibits nuclear translocation of YAP. Higher expression of PDK1 and an association between PDK1 and YAP are found in patients with progressive disease following osimertinib treatment. PDK1 is a central upstream regulator of two critical drug resistance pathways: PI3K/AKT/mTOR and YAP.
Boron-assisted abiotic polypeptide synthesis
Authors: Sumie Yuki , Sato Keiichiro , Kakegawa Takeshi , Furukawa Yoshihiro 
Published: May 2023

AbstractThe emergence of proteins and their interactions with RNAs were a key step in the origin and early evolution of life. The abiotic synthesis of peptides has been limited in short amino acid length and is favored in highly alkaline evaporitic conditions in which RNAs are unstable. This environment is also inconsistent with estimated Hadean Earth. Prebiotic environments rich in boron are reportedly ideal for abiotic RNA synthesis. However, the effects of boron on amino acid polymerization are unclear. We report that boric acid enables the polymerization of amino acids at acidic and near-neutral pH levels based on simple heating experiments of amino acid solutions containing borate/boric acid at various pH levels. Our study provides evidence for the boron-assisted synthesis of polypeptides in prebiotically plausible environments, where the same conditions would allow for the formation of RNAs and interactions of primordial proteins and RNAs that could be inherited by RNA-dependent protein synthesis during the evolution of life.
GAP43-dependent mitochondria transfer from astrocytes enhances glioblastoma tumorigenicity
Authors: Watson Dionysios C. , Bayik Defne , Storevik Simon , Moreino Shannon Sherwin , Sprowls Samuel A. , Han Jianhua , Augustsson Mina Thue , Lauko Adam , Sravya Palavalasa , Røsland Gro Vatne , Troike Katie , Tronstad Karl Johan , Wang Sabrina , Sarnow Katharina , Kay Kristen , Lunavat Taral R. , Silver Daniel J. , Dayal Sahil , Joseph Justin Vareecal , Mulkearns-Hubert Erin , Ystaas Lars Andreas Rømo , Deshpande Gauravi , Guyon Joris , Zhou Yadi , Magaut Capucine R. , Seder Juliana , Neises Laura , Williford Sarah E. , Meiser Johannes , Scott Andrew J. , Sajjakulnukit Peter , Mears Jason A. , Bjerkvig Rolf , Chakraborty Abhishek , Daubon Thomas , Cheng Feixiong , Lyssiotis Costas A. , Wahl Daniel R. , Hjelmeland Anita B. , Hossain Jubayer A. , Miletic Hrvoje , Lathia Justin D. 
Published: May 2023

AbstractThe transfer of intact mitochondria between heterogeneous cell types has been confirmed in various settings, including cancer. However, the functional implications of mitochondria transfer on tumor biology are poorly understood. Here we show that mitochondria transfer is a prevalent phenomenon in glioblastoma (GBM), the most frequent and malignant primary brain tumor. We identified horizontal mitochondria transfer from astrocytes as a mechanism that enhances tumorigenesis in GBM. This transfer is dependent on network-forming intercellular connections between GBM cells and astrocytes, which are facilitated by growth-associated protein 43 (GAP43), a protein involved in neuron axon regeneration and astrocyte reactivity. The acquisition of astrocyte mitochondria drives an increase in mitochondrial respiration and upregulation of metabolic pathways linked to proliferation and tumorigenicity. Functionally, uptake of astrocyte mitochondria promotes cell cycle progression to proliferative G2/M phases and enhances self-renewal and tumorigenicity of GBM. Collectively, our findings reveal a host–tumor interaction that drives proliferation and self-renewal of cancer cells, providing opportunities for therapeutic development.
A zeroing neurodynamics‐based location method for nodes in underwater acoustic sensor network
Authors: Wang Shuqiao , Du Xiujuan , Deng Tiantai 
Published: May 2023

AbstractZeroing neurodynamics methodology, which dedicates to finding equilibrium points of equations, has been proven to be a powerful tool in the online solving of problems with considerable complexity. In this paper, a method for underwater acoustic sensor network (UASN) localisation is proposed based on zeroing neurodynamics methodology to preferably locate moving underwater nodes. A zeroing neurodynamics model specifically designed for UASN localisation is constructed with rigorous theoretical analyses of its effectiveness. The proposed zeroing neurodynamics model is compatible with some localisation algorithms, which can be utilised to eliminate error in non‐ideal situations, thus further improving its effectiveness. Finally, the effectiveness and compatibility of the proposed zeroing neurodynamics model are substantiated by examples and computer simulations.
An adaptive synchronous rectifier driving strategy for unregulated LLC resonant converter
Authors: Wei Yuqi , Li Ziang , Liu Jinjun 
Published: May 2023

AbstractLLC resonant converters are widely adopted in many different industrial applications due to their high efficiency operation. To further improve LLC resonant converters' efficiency, the secondary unregulated diode rectifier is replaced by the synchronous rectifier (SR). In many applications, LLC converter is designed to operate at resonant frequency to maximize the system efficiency and act as a DC transformer (DCX). The SR driving signal is set as the same as the primary driving signal to work in an open‐loop mode. However, the resonant frequency will deviate due to the tolerance, working environment, and ageing effect of circuit components, which will lead to the degradation of the system efficiency and output voltage variation. Unfortunately, most of the existing techniques cannot be simply adopted in SR LLC DCX. Therefore, an adaptive SR driving strategy that can compensate the circuit components' variations is necessary for SR LLC DCX. Inan adaptive SR strategy based on the constant voltage gain characteristic at resonant frequency point is proposed. The proposed strategy is applicable for all different scenarios with easy implementation and low cost.
Peak to average power ratio reduction techniques based on chirp selection for single and multi‐user orthogonal chirp division multiplexing system
Authors: Savaux Vincent 
Published: May 2023

AbstractThis article deals with peak to average power (PAPR) reduction in a single and multi‐user orthogonal chirp division multiplexing (OCDM) context. Two methods for PAPR reduction based on the selection of the frequency variation (up or down) of the chirps are first presented in a single user system. The first technique consists in considering two OCDM signals generated with up and down chirps, respectively, and selecting the one offering lowest PAPR. The second PAPR reduction method is based on usual clipping, and in that case the chirp selection aims to reduce the clipping noise. An adapted receiver is presented, based on the maximum likelihood estimation of the frequency variation (up or down) of the chirp. Then, a general procedure for multi‐user OCDM transmission is introduced, where a sub‐band of the available bandwidth is dedicated to each user, whose frequency of the chirps varies within this sub‐band. Next, the PAPR reduction techniques are generalised to this multi‐user OCDM system. Moreover, a performance analysis of the first PAPR reduction method is developed, and it is shown through simulations that theoretical and numerical results match for both Nyquist rate and oversampled signals. It is also shown that the chirp selection reduces the clipping noise, and improves the bit error rate performance compared with clipping only.
An approach for selecting optimal locations for electric vehicle solar charging stations
Authors: Hisoglu Sinem , Tuominen Anu , Huovila Aapo 
Published: May 2023

AbstractElectric vehicles (EVs) are seen as a solution to reduce transport‐related greenhouse gas emissions. A major obstacle to wider adoption is the insufficient amount of charging stations. Furthermore, supplying charging stations with renewable energy is still in its infancy. The selection of optimal locations for charging stations is important to best serve the users and maximise the possibilities of renewable energy use. Given this background, this study developed an approach for Solar‐supplied Electric Vehicle Charging Station (EVCS) location selection by combining EVCS and solar farm site selection studies using Geographical Information System (GIS) and Analytic Hierarchy Process (AHP). The study determined the most important criteria for site selection based on previous solar and EVCS site selection studies and expert opinions. The 10 most important criteria according to the survey results were: availability of power, solar energy potential, solar panel installation cost, number of EVs, operation and management costs, land cost, distance from roads/highways, distance from current EVCSs, industrial capability of installation and distance to high population density centres. The importance weights of these criteria were assigned using AHP method. The findings are expected to benefit urban planners, decision‐makers, and researchers designing solar‐supplied EV charging infrastructure.
Coherence‐based integrated detection and assessment algorithm for voltages and currents unbalance/disturbance in three‐phase synchronous generators: A validation of simulation results
Authors: Mahmoud Ragab Abd Allah 
Published: May 2023

AbstractThe phenomenon of imbalance is a variation of voltage and current waveforms from a perfect sinusoidal waveform, which is considered a crucial challenge in power systems. Uneven loads and disturbances result in three‐phase voltage/current unbalance that leads to a temperature rise and low output curves at synchronous machines. Thus, the unbalance/fault must be recognized and avoided. This article suggests a methodology to detect and evaluate three‐phase voltage and current unbalance/fault using a coherence algorithm. The suggested scheme develops integrated protection functions that can be divided into three modules: voltage unbalance, current unbalance, and power factor unbalance. Therefore, it can be useful in mitigation techniques applied to compensate the voltage unbalance effects. The present protection introduces a new proposal of closed‐tripping curves based on the values range of nine coherence factors. To investigate the protection performance, a segment of power grid with real parameters’ information is simulated utilizing ATP platform. Several fault types, such as shunt and series faults, are conducted on the simulated system to analyze the results and monitor the system status using the coherence statistic processed in MATLAB software. The results show that the approach is smart, swift, precise, reliable and stable. Moreover, the algorithm can be practically implemented, and represents a base for digital unbalance/fault detectors and relays because its performance is superior in detecting Power Quality Disturbances (PQDs).
Autismus-Spektrum-Störungen im Erwachsenenalter: Empirische
Befunde zu Komorbiditäten, Differenzialdiagnosen und dem klinischen
Nutzen des AQ
Authors: Sappok Tanja , Bayer Mareike , Tarasova Daria , Kaiser Heika , Bergmann Thomas 
Published: May 2023

Zusammenfassung
Ziel Erfassung von Differenzialdiagnosen (DD) und Komorbiditäten
bei Erwachsenen mit Autismusverdacht, Überprüfung des Autismus
Quotient (AQ) auf seine Eignung für das Screening.
Methode Stichprobe N=106; ROC-Analyse des AQ gegen das klinische
Expertenurteil.
Ergebnisse Komorbide affektive Störungen in beiden Gruppen
(48%), DD waren Angst- (33%) und
Persönlichkeitsstörungen (22%). AQ: AUC=0,527,
Sensitivität/Spezifität von
70%/35%.
Schlussfolgerungen Erwachsene mit Autismusverdacht sind durch DD und
Komorbiditäten hoch belastet. Der AQ ist für das Screening nicht
geeignet.
Return-to-Work – Übergangsprozesse nach Behandlung in
einem psychiatrischen Akutkrankenhaus
Authors: Blank Daniela , Lang Anne , Brucks Adele , Riedl Lina , Brieger Peter , Hamann Johannes 
Published: May 2023

Zusammenfassung
Ziel der Studie Erwerbstätige mit einer psychischen Erkrankung
haben nach einer psychischen Krise oft massive Schwierigkeiten, ihre Arbeit
wiederaufzunehmen. Im Mittelpunkt der Studie steht die Frage, wie Menschen den
Übergang zwischen akutpsychiatrischer Klinik und Arbeitsplatz
erleben.
Methodik Der Studie liegt ein qualitatives Forschungsdesign (Grounded
Theory) zugrunde. Zehn narrative Interviews mit erkrankten Arbeitnehmern sowie
vier Gruppeninterviews mit professionellen
„Rückkehr-Begleitern“ (Return-to-Work-Experten) wurden
geführt.
Ergebnisse Die vorliegende Analyse zeigt, dass das Zusammenspiel der
beteiligten Akteure von enormer Bedeutung ist. Wesentlich ist, wie die
Beteiligten den Rückkehrprozess deuten und welche
Handlungsaufforderungen infolge dessen an die Beteiligten adressiert werden.
Schlussfolgerungen Ein arbeitsplatzbezogenes Entlassmanagement sollte
Unterstützungsangebote vorhalten, die an den Erwartungshaltungen der
Beteiligten ansetzen und einen gemeinschaftlichen Deutungsprozess
fördern bzw. in Gang setzen.
Assessing Equitable Recruitment in a Digital Health Trial for Asthma
Authors: Plombon Savanna , S. Rudin Robert , Sulca Flores Jorge , Goolkasian Gillian , Sousa Jessica , Rodriguez Jorge , Lipsitz Stuart , Foer Dinah , K. Dalal Anuj 
Published: May 2023

Abstract
Objective This study aimed to assess a multipronged strategy using primarily digital methods to equitably recruit asthma patients into a clinical trial of a digital health intervention.
Methods We approached eligible patients using at least one of eight recruitment strategies. We recorded approach dates and the strategy that led to completion of a web-based eligibility questionnaire that was reported during the verbal consent phone call. Study team members conducted monthly sessions using a structured guide to identify recruitment barriers and facilitators. The proportion of participants who reported being recruited by a portal or nonportal strategy was measured as our outcomes. We used Fisher's exact test to compare outcomes by equity variable, and multivariable logistic regression to control for each covariate and adjust effect size estimates. Using grounded theory, we coded and extracted themes regarding recruitment barriers and facilitators.
Results The majority (84.4%) of patients who met study inclusion criteria were patient portal enrollees. Of 6,366 eligible patients who were approached, 627 completed the eligibility questionnaire and were less frequently Hispanic, less frequently Spanish-speaking, and more frequently patient portal enrollees. Of 445 patients who consented to participate, 241 (54.2%) reported completing the eligibility questionnaire after being contacted by a patient portal message. In adjusted analysis, only race (odds ratio [OR]: 0.46, 95% confidence interval [CI]: 0.28–0.77, p = 0.003) and college education (OR: 0.60, 95% CI: 0.39–0.91, p = 0.016) remained significant. Key recruitment barriers included technology issues (e.g., lack of email access) and facilitators included bilingual study staff, Spanish-language recruitment materials, targeted phone calls, and clinician-initiated “1-click” referrals.
Conclusion A primarily digital strategy to recruit patients into a digital health trial is unlikely to achieve equitable participation, even in a population overrepresented by patient portal enrollees. Nondigital recruitment methods that address racial and educational disparities and less active portal enrollees are necessary to ensure equity in clinical trial enrollment.
Use of the N–O Bonds in N-Mesyloxyamides and N-Mesyloxyimides To Gain Access to 5-Alkoxy-3,4-dialkyloxazol-2-ones and 3-Hetero-Substituted Succinimides: A Combined Experimental and Theoretical Study
Authors: Peters René , Pfitzer Lucca , Heitkämper Juliane , Kästner Johannes 
Published: May 2023

AbstractThe reactivity of N-mesyloxyamides and -imides with bases was studied based on the initial hypothesis of a possible [3,3]-rearrangement. While the intended α-sulfonyloxylation method could not be developed, the formation of valuable N-containing heterocyclic products was found. Treating N-mesyloxyamides with triethylamine gave fully substituted oxazolone products, which are masked α-amino acid derivatives. The products were identified by a computational approach, which revealed that α-lactams are first formed from an initial enolate by an intramolecular nucleophilic substitution. As strained intermediates, they readily rearrange to the oxazolone products. With a cyclic N-mesyloxyimide, elimination to a maleimide was found. This might indicate that sulfonyloxylation has taken place, but the corresponding product probably underwent elimination. Nucleophiles were then added to trap this suspected intermediate by substitution of methanesulfonate. That way, quaternary α-nitrogen- and α-oxygen-substituted succinimides could be formed, which represent a pharmacologically important class that has received much attention for its value in drug design.
Meniscal Load and Load Distribution in the Canine Stifle after Modified Tibial Tuberosity Advancement with 9 mm and 12 mm Cranialization of the Tibial Tuberosity in Different Standing Angles
Authors: Schmutterer Johannes Maximilian , Augat Peter , Greinwald Markus , Meyer-Lindenberg Andrea 
Published: May 2023

Abstract
Objectives The aim of this study was to investigate the kinetic and kinematic changes in the stifle after a modified tibial tuberosity advancement (TTA) with 9 and 12 mm cranialization of the tibial tuberosity in different standing angles.
Study Design Biomechanical ex vivo study using seven unpaired canine cadaver hindlimbs. Sham TTA surgery was performed. Motion sensors were fixed to the tibia and the femur for kinematic data acquisition. Pressure mapping sensors were placed between femur and both menisci. Thirty percent body weight was applied to the limbs with the stifle in 135 or 145 degrees of extension. Each knee was tested in 135 degrees with intact cranial cruciate ligament (CCL) and deficient CCL with 12 mm cranialization of the tibial tuberosity in 135 and 145 degrees of extension. The last two tests were repeated with 9 mm.
Results Transection of the CCL altered kinematics and kinetics. Tibial tuberosity advancement with 12 mm cranialization sufficiently restored stifle kinematics in 135 and 145 degrees but 9 mm TTA failed to do so in 135 degrees. The same effects were seen for internal rotation of the tibia. After TTA, a significant reduction in the force acting on both menisci was detected.
Conclusion Tibial tuberosity advancement could restore stifle kinematics and meniscal kinetics after transection of the CCL ex vivo in the present study. Tibial tuberosity advancement reduced the contact force ratio on both menisci significantly. No changes of peak pressure and peak pressure location occurred following TTA under any of the tested experimental settings. Increased stifle extension (145 degrees) might lead to more stability, contradictory to biomechanical theory.