bluuebunny/crossref_metadata_2025_split huggingface dataset:
Utility of GATA-3 and associated immunohistochemical markers in the differential diagnosis of poorly differentiated urothelial carcinoma
Authors: Naik Meenatai , Rao B.Vishal , Challa Sundaram , Fonseca Daphne , Sudha S. Murthy , Giridhar Ashwin , Sharma Rakesh , Raju K. V. V. N. , Rao T. Subramanyesh war 
Published: April 2023

ABSTRACT

Aims:
The aims are to study the utility of GATA-3 along with panel of immunohistochemical (IHC) markers in the differential diagnosis of primary and metastatic poorly differentiated urothelial carcinoma (UC).

Settings and Design:
This is a prospective and retrospective observational study.

Subjects and Methods:
Poorly differentiated carcinomas of urinary tract and metastatic sites from January 2016 to December 2017 were subjected to a panel of four IHC markers including GATA-3, p63, Cytokeratin (CK) 7, and CK20. Additional markers such as p16, an enzyme called alpha-methylacyl-CoA racemase, CDX2, and thyroid transcription factor 1 were also done depending on the morphology and site.

Statistical Analysis Used:
The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of GATA-3 in making the diagnosis of UC were calculated.

Results:
Forty-five cases were included in the study and after appropriate IHC, the diagnosis was resolved as UC in 24 cases. GATA-3 was positive in 83.33% of UC; all the four markers positive in 33.33% and all negative in 4.17% of UC. However, at least one of the four markers was present in 95.83% of UC, except in sarcomatoid UC. GATA-3 had 100% specificity in differentiating from prostate adenocarcinoma.

Conclusion:
GATA-3 is a useful marker in the diagnosis of UC in the primary and metastatic sites with a sensitivity of 83.33%. GATA-3 along with other IHC markers in correlation with clinical and imageological features is necessary for making specific diagnosis of poorly differentiated carcinoma.
Angle of concavity in planning target volume can be adopted as selection criteria for intensity-modulated radiation therapy or three-dimensional conformal radiotherapy technique in brain tumors
Authors: Gupta Meenu , Kant Ravi , Kumar Viney , Saini Manju , Nautiyal Vipul , Bhadra Kallol , Ahmad Mushtaq 
Published: April 2023

ABSTRCT

Introduction:
With innovation of medical imaging, radiotherapy attempts to conform the high dose region to the planning target volume (PTV). The present work aimed to assess the angle of concavity in PTV can be adopted as selection criteria for intensity-modulated radiation therapy (IMRT) or three-dimensional conformal radiotherapy (3DCRT) technique in Brain tumors.

Materials and Methods:
Thirty previously irradiated patients with brain tumors were replanned with both 3DCRT and IMRT technique. Angle of concavity (dip) in the PTV near the organs at risk was measured in the contoured structure set images of each patient. These cases were divided into three groups where angles were 0°, >120° and <120°. Dose of 60 Gy/30# was fixed.

Results:
In Group 1, the IMRT plan had better TV95% as compared to 3DCRT respectively with significant P value (P = 0.002). Mean of conformity index (CI) and Homogeneity Index (HI) were comparable. For Group 2 (angle >120°), the IMRT plan had better TV95% as compared to 3DCRT respectively with a significant P value (P = 0.021). HI and CI were not significant. For Group 3 (<120°), IMRT plan had better TV95% as compared to 3DCRT respectively with a significant P value (P = 0.001). HI and CI were better in IMRT arm with significant P value.

Conclusion:
The results from this study showed that the angle of concavity can be considered as an additional objective tool for selection criteria whether tumor can be treated with IMRT or 3DCRT. Tumors where angle of concavity was <120°, HI and CI provided more uniformity and conformity of dose distribution inside PTV with significant P values.
Outcomes and survival rates of childhood osteosarcoma in Iran, A report from MAHAK Pediatric Cancer Treatment and Research Center, from 2007 to 2020
Authors: Mehrvar Azim , Mehrvar Narjes , Sadeghi Yasaman , Tashvighi Maryam 
Published: April 2023

ABSTRACT

Background:
Osteosarcoma is one of the most common childhood bone malignancies. Although chemotherapy protocol including methotrexate is an effective treatment for osteosarcoma, some other regimens have excluded it because of its complications.

Methods:
This retrospective study was conducted on 93 children younger than 15 years old who were diagnosed with osteosarcomafrom March 2007 to January 2020. Two chemotherapy protocols were administrated for patients, namely, DCM protocol (Doxorubicin-Cisplatin-Methotrexate) and German protocol (excluding methotrexate). All statistical analysis was conducted using SPSS-25 software.

Results:
Among patients, 47.31% were male. Patients’ age ranged from 3 to 15 with the mean of 10.41 ± 0.32 years. Femur was the most frequent primary tumor site (59.14%), followed by tibia (22.58%). Metastasis rate at diagnosis was 17.20% in our study. Furthermore, the 5-year overall survival (OS) of total patients was 37.3 ± 7.5%, whereas the 5-year OS of males and females was 33.6 ± 10.9% and 39.8 ± 10.6%, respectively. The 5-year OS of methotrexate regimen was 15.6 ± 9.6%, whereas that of methotrexate-free protocol was 50.2 ± 9.0%.

Conclusions:
Female patients had better survival rates than males. In addition, the chemotherapy protocol excluding methotrexate significantly increased the overall and event free survival of patients.
Modulatory role of BV6 and chloroquine on the regulation of apoptosis and autophagy in non-small cell lung cancer cells
Authors: Beg Mirza Masroor Ali , Saxena Alpana , Singh Vijay Kumar , Akhter Juheb , Habib Haroon , Raisuddin Sheikh 
Published: April 2023

ABSTRACT

Aims:
Non-small cell lung cancer (NSCLC) is one of the aggressive tumors mostly diagnosed in the advanced stage. Therapeutic failure and drug resistance pose a major problem in NSCLC treatment primarily due to alterations in autophagy and loss of apoptosis. Therefore, the present study aimed to investigate the importance of the second mitochondria-derived activator of caspase mimetic BV6 and autophagy inhibitor chloroquine (CQ) on the regulation of apoptosis and autophagy, respectively.

Subjects and Methods:
Study was conducted on NCI-H23 and NCI-H522 cell lines to evaluate the effect of BV6 and CQ on the transcription and translation level of LC3-II, caspase-3, and caspase-9 genes by quantitative real-time-polymerase chain reaction and western blotting techniques.

Results:
In NCI-H23 cell line, BV6 and CQ treatments showed increased mRNA and protein expression of caspase-3, and caspase-9 compared to its untreated counterpart. BV6 and CQ treatments also caused downregulation of LC3-II protein expression compared to its counterpart. In NCI-H522 cell line, BV6 treatment showed a significantly increased expression of caspase-3 and caspase-9 mRNA and protein expression levels whereas BV6 treatment downregulated the expression level of LC3-II protein. A similar pattern was also observed in CQ treatment when compared with the respective controls. Both BV6 and CQ modulated in vitro expression of caspases and LC3-II which have critical regulatory roles in apoptosis and autophagy, respectively.

Conclusions:
Our findings suggest that BV6 and CQ could be promising candidates in NSCLC treatment and there is a need to explore them in vivo and in clinical applications.
The efficacy and outcomes of stereotactic body radiotherapy in adrenal gland metastases
Authors: Kekilli Esra , Demirkasımoğlu Taciser 
Published: April 2023

ABSTRACT

Aim:
This retrospective study presents our single-institutional experience with stereotactic body radiotherapy for adrenal gland metastases.

Materials and Methods:
We evaluated patients with adrenal metastases treated by stereotactic body radiotherapy (SBRT) from 2014 to 2020. We performed an analysis of 35 patients. The median age of the patients was 62.2. Dosimetric parameters and treatment outcomes were evaluated.

Results:
The primary diagnosis of the majority of patients was non-small cell lung cancer (94.3%). Treatment was performed in a median of 3 fractions, and the median prescribed dose was 24 Gy (range 22,5–27). The median follow-up was 17 months. Treatment response according to Response Evaluation Criteria in Solid Tumours was categorized as complete response in 11 patients, partial response in nine patients, stable disease in 7, and progressive disease in eight patients. Twenty seven patients had oligometastatic disease and treatment response. Patients with oligometastatic disease had a significantly higher rate of complete response and partial response to treatment than patients with common disease (P = 0,011). The 6-month and 1-year local control rates were 68.4% and 43%, respectively. In general, SBRT was well tolerated and no acute toxicities were observed.

Conclusion:
Our retrospective study shows that SBRT can be applied safely in adrenal metastases with good results especially in patients with oligometastatic disease.
Influence of advanced age on the prognosis of triple-negative breast cancer patients: A surveillance, epidemiology, and end results-based study
Authors: Tan Haosheng , Fu Deyuan 
Published: April 2023

ABSTRACT

Introduction:
Age at diagnosis has shown significant effect on the prognosis in breast cancer patients. However, whether age is an independent risk factor remains controversial. Furthermore, population-based estimates of age on the prognosis impact in triple-negative breast cancer are still lacking. The aim of this study was to analyze the influence of age and other factors on the prognosis and survival of triple-negative breast cancer patients.

Materials and Methods:
We used the surveillance, epidemiology, and end results program data from 2011 to 2014. A retrospective cohort study was conducted to investigate prognosis factors in triple-negative breast cancer. Patients were divided into two groups according to age at diagnosis: 75 + years (the elderly patients) and < 75 years (reference group). The clinicopathologic characteristics of different age groups were compared using Chi-square tests. Overall survival (OS) and breast cancer-specific survival were analyzed using the Kaplan–Meier method. Prognostic factors were compared using the Cox proportional hazards model. We also analyzed the difference of distant metastasis at initial diagnosis on every group.

Results:
A total of 21,429 triple-negative breast cancer patients were included in our study. The mean breast cancer-specific survival time of triple-negative breast cancer was 70.5 months for the reference group and 62.4 months for the elderly group. Survival analysis showed that the breast cancer-specific survival rate was 78.9% for the reference group and 67.4% for the elderly group. The mean OS time was 69.0 months for the reference group and 52.3 months for the elderly group. The 5-year OS of triple-negative breast cancer patients was 76.4% for the reference group and 51.3% for the elderly group. The prognosis of elderly patients is much poor than reference group. Univariate Cox regression analysis showed that age, race, marital status, histological grade, stage, T, N, M, surgery, radiotherapy, and chemotherapy were risk factors for triple-negative breast cancer (TNBC) (P < 0.05). Multivariate Cox regression analysis showed that age, race, marital status, histological grade, stage, T, N, M, surgery, radiotherapy, and chemotherapy were independent risk factors for TNBC (P < 0.05).

Conclusions:
Age is an independent risk factor for the prognosis of TNBC patients. Elderly triple-negative breast cancer patients displayed obvious lower 5-year survival rate compared to reference group, even though they have better grade stage, minor tumor, less lymph node metastasis. The lower rate of marital status, radiotherapy, chemotherapy, surgery, and higher rate of metastasis at diagnosis must contribute to their poor outcome.
Zootherapeutic documentation from Tiruppur district, Tamil Nadu, India
Authors: Radha Prakasam , Udhayavani Chinniaya , Nagaraj Raju , Sivaranjani Kumarasamy 
Published: April 2023

Introduction:
Animals and their parts have been used as an important source in the traditional systems of medicine such as Ayurveda, Siddha, Unani, and folklore. The present study was aimed to document the medicinal uses of animals and animal products used by the inhabitants of Tiruppur District, Tamil Nadu.

Materials and Methods:
A medico ethnobotanical survey was conducted from December 2017 to December 2020 in order to collect the information on the animals and their parts used in the treatment of various ailments by both tribal and non-tribal inhabitant of Tiruppur District, Tamil nadu. The documentation was done by conducting face-to-face interview with the informants such as traditional medicinal practitioners, folk healers, and indigenous with their prior consent.

Results:
67 people were interviewed and the therapeutic values of 28 animals and their products used in the treatment of various ailments such as dermatological infection/diseases, hemorrhoides, skeleto-muscular system disorder, respiratory system diseases, genito-urinary ailments, etc. were recorded and documented with their tamil name, zoological name, family, part used, mode of administration, and ailments treated.

Conclusion:
The present study revealed that, though the inhabitants possess the traditional knowledge to use animal products for various diseases, currently very few are in practice for their primary health care needs.
Tratamento ortodôntico pré-protético
Authors: Barbosa Adrielly Oliveira , Oliveira Ana Paula Lemos Costa de , Melo Eduardo Henriques de 
Published: April 2023

A estética do sorriso está sujeita a diversos fatores, dentre eles, sobressai cor, textura e forma dos dentes, acrescentam-se a arquitetura e coloração do tecido gengival aparente. Deste modo a importância da idealização e a previsão de todos os fatores cirúrgicos e protéticos envolvidos no tratamento ortodôntico são de grande importância, buscando à supressão de problemas que possam causar dano a saúde como também comprometer a estética dental O objetivo do trabalho é: descrever a importância do planejamento para adequação do espaço protético no tratamento ortodôntico, descrever os fundamentos biológicos que justificam a utilização do tratamento ortodôntico pré-protético, caracterizar algumas etapas clínicas na adequação do espaço no tratamento ortodôntico, com base em evidências científicas e nos princípios da odontologia. A técnica de pesquisa utilizada foi baseada em livros, artigos científicos, teses e dissertações de mestrado e doutorado, com foco na área Ortodontia e Prótese Dentária. Nos consultórios de ortodontia é cada vez maior o número de pacientes adultos, que apresentam múltiplas percas dentárias, Além de proporcionar um problema estético para o paciente, esta ausência dentária impede a reabilitação protética dos dentes perdidos, pois o espaço interoclusal para a reconstrução da coroa se torna insuficiente, necessitando de uma adequação do espaço protético prévio ao tratamento reabilitador, com isso conseguimos uma melhora tanto na estética, como na função e consequentemente na longevidade de todo o tratamento reabilitador.
TÜRKİYE SAĞLIK SİSTEMİNİN DÖNÜŞÜMÜ (2003-13): TIBBİ TEKNOLOJİNİN YAYILIMI
Authors: BOYACI İsrafil 
Published: April 2023

Amaç: Bu makale, sağlık hizmetlerinin sunumunda Türkiye sağlık sisteminin kapasitesinin bütünüyle arttığı Sağlıkta Dönüşüm Programı (2003-2013) boyunca ve takip eden yıllarda, hastanelerin teknolojik donanımının nasıl değiştiğini açıklığa kavuşturmayı amaçlamaktadır.
Yöntem: Makalede, hastanelerdeki başlıca tanıya yardımcı tıbbi görüntüleme teknolojilerinin (MR, BT, Ultrason, Doppler Ultrason, EKO) 2002-2020 yılları içerisindeki yayılımları ve sektörlere dağılımlarının seyri betimlenerek, bu tıbbi cihazların ülkedeki toplam sayılarındaki değişimler yeniliklerin yayılımının incelenmesinde yaygın olarak kullanılan S eğrisi biçimindeki büyüme evreleri çerçevesinde ele alındılar.
Bulgular: Dönüşüm Programı boyunca ve sonrasında ülkedeki hastanelerin tıbbi cihaz kapasitesinde hızlı büyüme kaydedildiği açıkça görülmüştür. MR ve BT cihazlarının yayılım evrelerini geçirerek piyasanın taşıma kapasitesine yakınsama eğilimde olduğu, Ultrason cihazı sayısının yavaşlayan büyüme evresinde bulunduğu, Doppler Ultrason ve EKO cihazlarının ise hızlı büyüme evrelerini tamamlamak ve yavaşlayan büyüme evresine henüz geçmek üzere oldukları değerlendirilmiştir. 2014’lü yıllardan sonra MR, BT, Doppler Ultrason ve EKO cihazlarının özel hastanelerdeki büyüme hızları azalmış, fakat kamu hastanelerinde istikrarlı veya hızlanarak büyümeleri devam etmiştir.
Özgünlük: Böylece, Türkiye’de sağlık sisteminin geçirdiği güncel dönüşüm 'teknolojinin yayılımı' çerçevesinde incelenerek Türkiye sağlık sisteminin teknoloji kapsamı ve ülke sağlık sisteminin teknoloji yoğunluğunda kamu ve özel kesimlerinin katkıları aydınlatılmıştır.
IMPLIKASI PROSES HUKUM YANG ADIL TERHADAP KELOMPOK KRIMINAL BERSENJATA DAN REKOMENDASI KESEJAHTERAAN SOSIAL DI PAPUA
Authors: Yusuf Achmad , Khair Otti Ilham , Kusuma Gede Wijaya , Nasruddin Muhammad 
Published: April 2023

Abstract
This study aims to implicate a fair legal process against armed criminal groups and social welfare recommendations in Papua. In order to carry out a better, systematic and directed study in accordance with the expected goals, this writing is based on the results of research or legal studies. The results of this study are in the form of an acronym for the Armed Criminal Group, which is a group that often spreads terror against both civilians and the TNI and Polri in the Papua region. The aim of the KKB Papua is to break away from the Unitary State of the Republic of Indonesia (NKRI). Therefore, the Papuan KKB can be called a separatist movement, whose movements often result in fatalities. Before being born as KKB, this group was formerly known as the Free Papua Organization (OPM) and a fair trial or fair trial is a principle which is an indicator of the development of a just society and legal system. Without the application of fair trial principles, many innocent people will enter the criminal justice system and will most likely end up in jail. Without the application of fair trial principles, law and public trust in law and the justice system will collapse.
STUDY OF ANALYSIS OF CHILD VICTIMS OF CRIME PROTECTION IN A VICTIMOLOGICAL PERSPECTIVE
Authors: Marzuki Marzuki 
Published: April 2023

This research aims to improve the protection of children of crime victims, which often occurs when the provision of services to children who are temporary or permanent victims of psychological, physical and social suffering is neglected. It is a study to analyze from the viewpoint of victimology.The specification or type of research in this research is descriptive in nature and uses prescriptive legal research methods through several approaches.The statutory regulatory approach (statutory approach) and the conceptual approach (conceptual approach).Investigations have shown that various laws have been adopted as legal policies to implement the constitutional provisions of the 1945 Constitution of the Republic of Indonesia, including Presidential Decree No. 36 of 1990 on ratification, in order to protect children in conflict with the law. It is shown that the regime has emerged. Convention on the Rights of the Child (Convention on the Rights of the Child), Law No. 4 of 1979 on Child Welfare, Law No. 8 of 1981 on Criminal Procedure Code, Law No. 39 of 1997 on Juvenile Courts, Law No. 39 of 1999 on Human Rights, Law No. 23 of 2014 on Amending Law No. 23 of 2002 on Child Protection and Law No. 35 of 2014 on Juvenile Criminal Justice System Law No. 11 Including children in conflict with the law to provide legal protection as both perpetrators and victims. In light of these various legal systems, the police, prosecutors, and judges in the law enforcement agency (prosecutor's office) always strive to provide children with the best progressive laws for children in line with the concept of juvenile justice for children. It must be the embodiment of teaching, nurturing and protection of Prioritize the application of restorative justice and diversion to ensure that victims' rights are not ignored, and protect child victims of crime from a victimological perspective.In summary, the legal protection of children of crime victims in Indonesia entitles them to various rights, including: B. Losses such as the right to compensation, the right to treatment, the right to be intimidated by the perpetrator, the right to counseling and rehabilitation, especially the perpetrator's inability to pay compensation to the victim due to the existence of the Victim Compensation Office. case .
PERMOHONAN PERWALIAN YANG DILAKUKAN IBU KANDUNG GUNA MENGELOLA DAN IZIN JUAL HARTA WARISAN ANAKNYA YANG MASIH DIBAWAH UMUR (Studi Putusan No:118/Pdt.P/2022/Pn Tjk)
Authors: Rusli Tami , Ainita Okta , Rachman Arif Nur 
Published: April 2023

Abstract

The constitution of the Republic of Indonesia Article 1 paragraph (three) Indonesia is a constitutional nation, anyone is no exception due to the fact that delivery is a prison difficulty. based totally on the effects of the studies and dialogue, the techniques for filing programs for guardianship and dealing with the belongings of minors at the Tanjung Karang District court docket (selection observe wide No:118/Pdt.P/2022/Pn Tjk). ought to whole several administrative requirements, the party submits 6 copies of the application, the Officer receives and checks the completeness of the utility, the Officer enters the identity of the birthday party/parties, posita, petitum software inside the SIPP application, assesses and makes the SKUM down payment for the case fee, offers commands to the Petitioner/candidates to deposit the quantity of case expenses indexed inside the SKUM through the precise financial institution. The utility will be finished in less than 1 month from the registration of the case. due to the law, after the guardian is appointed via the Tanjung Karang District court docket choose (choice study No:118/Pdt.P/2022/Pn Tjk), the applicant can take prison action on behalf of his infant who's nonetheless underage to emerge as a dad or mum and this electricity of sale is for looking after the sale/switch of asset rights from the applicant's husband. The father or mother appointed by the courtroom ought to additionally be accountable for all of the moves of the kid under his guardianship and the parent need to additionally represent him in all civil moves.
PERLINDUNGAN HUKUM KONSUMEN TERHADAP PEREDARAN KOSMETIK PALSU BERDASARKAN UU NOMOR 8 TAHUN 1999 TENTANG PERLINDUNGAN KONSUMEN DAN PERATURAN BPOM NOMOR 23 TAHUN 2019
Authors: Soemarwi Vera Wheny Setijawati , Ridzkia Yudith 
Published: April 2023

In general, law is defined as a set of rules of conduct that regulates and coerces society. A country uses law in every step of the way. Therefore, the law becomes a benchmark for state institutions in carrying out all their affairs. The existence of the Consumer Protection Law is a legal product created by legislative institutions to ensure that the law protects as well as stipulates the rights and obligations of consumers and business actors. The problem that is currently being discussed is the distribution of dangerous counterfeit cosmetic products. This research uses a socio-legal studies approach in examining the behaviour of cosmetic business actors in e-commerce media. This research aims to analyze the consumer protection law due to the use of dangerous cosmetic products and the role of BPOM in the distribution of dangerous cosmetics in Indonesia. The results of this research show that consumer protection in the distribution of dangerous cosmetics is regulated in the Consumer Protection Law, Health Law, Minister of Health Regulation, BPOM Regulation, and related technical regulations.