bluuebunny/crossref_metadata_2025_split huggingface dataset:
Direct oral anticoagulants for the treatment of cerebral venous thrombosis – a protocol of an international phase IV study
Authors: van de Munckhof Anita , Sánchez van Kammen Mayte , Krzywicka Katarzyna , Aaron Sanjith , Aguiar de Sousa Diana , Antochi Florina , Arauz Antonio , Barboza Miguel A. , Conforto Adriana B. , Dentali Francesco , Galdames Contreras Daniel , Ji Xunming , Jood Katarina , Heldner Mirjam R. , Hernández-Pérez María , Kam Wayneho , Kleinig Timothy J. , Kristoffersen Espen S. , Leker Ronen R. , Lemmens Robin , Poli Sven , Yeşilot Nilüfer , Wasay Mohammad , Wu Teddy Y. , Arnold Marcel , Lucas-Neto Lia , Middeldorp Saskia , Putaala Jukka , Tatlisumak Turgut , Ferro José M. , Coutinho Jonathan M. 
Published: September 2023

IntroductionCurrent guidelines recommend that patients with cerebral venous thrombosis (CVT) should be treated with vitamin K antagonists (VKAs) for 3–12 months. Direct oral anticoagulants (DOACs), however, are increasingly used in clinical practice. An exploratory randomized controlled trial including 120 patients with CVT suggested that the efficacy and safety profile of dabigatran (a DOAC) is similar to VKAs for the treatment of CVT, but large-scale prospective studies from a real-world setting are lacking.MethodsDOAC-CVT is an international, prospective, observational cohort study comparing DOACs to VKAs for the prevention of recurrent venous thrombotic events after acute CVT. Patients are eligible if they are 18 years or older, have a radiologically confirmed CVT, and have started oral anticoagulant treatment (DOAC or VKA) within 30 days of CVT diagnosis. Patients with an absolute contra-indication for DOACs, such as pregnancy or severe renal insufficiency, are excluded from the study. We aim to recruit at least 500 patients within a three-year recruitment period. The primary endpoint is a composite of recurrent venous thrombosis and major bleeding at 6 months of follow-up. We will calculate an adjusted odds ratio for the primary endpoint using propensity score inverse probability treatment weighting.DiscussionDOAC-CVT will provide real-world data on the comparative efficacy and safety of DOACs versus VKAs for the treatment of CVT.Clinical trial registrationClinicalTrials.gov, NCT04660747.
Lineage tracing for multiple lung cancer by spatiotemporal heterogeneity using a multi-omics analysis method integrating genomic, transcriptomic, and immune-related features
Authors: Song Yijun , Zhou Jiebai , Zhao Xiaotian , Zhang Yong , Xu Xiaobo , Zhang Donghui , Pang Jiaohui , Bao Hairong , Ji Yuan , Zhan Mengna , Wang Yulin , Ou Qiuxiang , Hu Jie 
Published: September 2023

IntroductionThe distinction between multiple primary lung cancer (MPLC) and intrapulmonary metastasis (IPM) holds clinical significance in staging, therapeutic intervention, and prognosis assessment for multiple lung cancer. Lineage tracing by clinicopathologic features alone remains a clinical challenge; thus, we aimed to develop a multi-omics analysis method delineating spatiotemporal heterogeneity based on tumor genomic profiling.MethodsBetween 2012 and 2022, 11 specimens were collected from two patients diagnosed with multiple lung cancer (LU1 and LU2) with synchronous/metachronous tumors. A novel multi-omics analysis method based on whole-exome sequencing, transcriptome sequencing (RNA-Seq), and tumor neoantigen prediction was developed to define the lineage. Traditional clinicopathologic reviews and an imaging-based algorithm were performed to verify the results.ResultsSeven tissue biopsies were collected from LU1. The multi-omics analysis method demonstrated that three synchronous tumors observed in 2018 (LU1B/C/D) had strong molecular heterogeneity, various RNA expression and immune microenvironment characteristics, and unique neoantigens. These results suggested that LU1B, LU1C, and LU1D were MPLC, consistent with traditional lineage tracing approaches. The high mutational landscape similarity score (75.1%), similar RNA expression features, and considerable shared neoantigens (n = 241) revealed the IPM relationship between LU1F and LU1G which were two samples detected simultaneously in 2021. Although the multi-omics analysis method aligned with the imaging-based algorithm, pathology and clinicopathologic approaches suggested MPLC owing to different histological types of LU1F/G. Moreover, controversial lineage or misclassification of LU2’s synchronous/metachronous samples (LU2B/D and LU2C/E) traced by traditional approaches might be corrected by the multi-omics analysis method. Spatiotemporal heterogeneity profiled by the multi-omics analysis method suggested that LU2D possibly had the same lineage as LU2B (similarity score, 12.9%; shared neoantigens, n = 71); gefitinib treatment and EGFR, TP53, and RB1 mutations suggested the possibility that LU2E might result from histology transformation of LU2C despite the lack of LU2C biopsy and its histology. By contrast, histological interpretation was indeterminate for LU2D, and LU2E was defined as a primary or progression lesion of LU2C by histological, clinicopathologic, or imaging-based approaches.ConclusionThis novel multi-omics analysis method improves the accuracy of lineage tracing by tracking the spatiotemporal heterogeneity of serial samples. Further validation is required for its clinical application in accurate diagnosis, disease management, and improving prognosis.
Mapping the intellectual structure and landscape of nano-drug delivery systems in colorectal cancer
Authors: Chang Yonglong , Ou Qinling , Zhou Xuhui , Nie Kechao , Yan Haixia , Liu Jinhui , Li Jing , Zhang Sifang 
Published: September 2023

Background: Colorectal cancer (CRC) is a prevalent malignancy affecting the digestive tract, and its incidence has been steadily rising over the years. Surgery remains the primary treatment modality for advanced colorectal cancer, complemented by chemotherapy. The development of drug resistance to chemotherapy is a significant contributor to treatment failure in colorectal cancer. Nanodrug delivery systems (NDDS) can significantly improve the delivery and efficacy of antitumor drugs in multiple ways. However, there is a lack of visualization of NDDS research structures and research hotspots in the field of colorectal cancer, and the elaboration of potential research areas remains to be discovered.Objective: To comprehensively explore the current research status and development trend of NDDS in CRC research.Methods: Bibliometric analysis of articles and reviews on NDDS for CRC published between 2002 and 2022 using tools including CiteSpace, VOSviewer, R-bibliometrix, and Microsoft Excel was performed.Results: A total of 1866 publications authored by 9,870 individuals affiliated with 6,126 institutions across 293 countries/regions were included in the analysis. These publications appeared in 456 journals. Abnous Khalil has the highest number of publications in this field. The most published journals are the International Journal of Nanomedicine, International Journal of Pharmaceutics, and Biomaterials. Notably, the Journal of Controlled Release has the highest citation count and the third-highest H-index. Thematic analysis identified “inflammatory bowel disease”,“ “oral drug delivery," and “ulcerative colitis” as areas requiring further development. Keyword analysis revealed that “ulcerative colitis,” “exosomes,” and “as1411”have emerged as keywords within the last 2 years. These emerging keywords may become the focal points of future research.Conclusion: Our findings reveal the current research landscape and intellectual structure of NDDS in CRC research which helps researchers understand the research trends and hot spots in this field.
Beyond recovery: toward rights-based mental health care — A cluster randomized wait-list controlled trial of a recovery and rights training for mental health professionals with or without first person accounts
Authors: Eiroa-Orosa Francisco José 
Published: September 2023

IntroductionMental health models grounded in Recovery and Rights are driving the advancement of transformative care systems through multifaceted actions, which encompass Continuing Professional Development. The objective of this work is to evaluate a training activity developed through a participatory process that included people with lived experience of psychosocial distress, their relatives, and mental health professionals.MethodsThe training focused on alternatives to diagnosis, recovery principles, rights-based care, and peer support. The evaluation followed a cluster randomized wait-list controlled design. Four hundred eighty-eight health professionals from eight care centers were randomized to three experimental conditions: a wait list control, which underwent a one-month interval between the baseline assessment and the training activity, and two experimental groups, with or without first-person accounts, which accessed the training immediately after completing the baseline assessment. The dependent variables measured at all follow-ups were beliefs and attitudes toward mental health service users’ rights. One hundred ninety-two professionals completed at least one follow-up and were included in the analyses.ResultsWe observed different evolutions of experimental and control groups with statistically significant differences for tolerance to coercion and total beliefs and attitudes scores. No differences were observed between the groups with or who attended training activities with or without first person accounts. Upon receiving the training activity, the control group had an evolution equivalent to the experimental groups.DiscussionThe results of this evaluation project provide compelling evidence for the need to expand recovery and rights training activities to reach a larger audience of mental health professionals These training activities hold the potential to positively influence the beliefs and attitudes of mental health professionals, ultimately contributing toward a better future for individuals with lived experience of psychosocial distress.
Genomic risk scores and oral contraceptive-associated ischemic stroke risk: a call for collaboration
Authors: Lin Forrest , Tomppo Liisa , Gaynor Brady , Ryan Kathleen , Cole John W. , Mitchell Braxton D. , Putaala Jukka , Kittner Steven J. 
Published: September 2023

BackgroundOral contraceptives (OCs) are generally safe but vascular risk factors increase OC-associated ischemic stroke risk. We performed a case-control study to evaluate whether a genomic risk score for ischemic stroke modifies OC-associated ischemic stroke risk.MethodsThe Genetics of Early-Onset Stroke study includes 332 premenopausal women (136 arterial ischemic stroke cases and 196 controls) with data on estrogen-containing OC use within 30 days before the index event (for cases) or interview (for controls). Using a previously validated genetic risk score (metaGRS) for ischemic stroke based on 19 polygenic risk scores for stroke and stroke-associated risk factors, we stratified our combined case-control sample into tertiles of genomic risk. We evaluated the association between OC use and ischemic stroke within each tertile. We tested if the association between OC use and ischemic stroke depended on the genomic risk of stroke using logistic regression with an OC use × metaGRS interaction term. These analyses were performed with and without adjustment for smoking, hypertension, diabetes, coronary heart disease, and body mass index.ResultsAfter adjustment for vascular risk factors, the odds ratio of OC use was 3.2 (1.7–6.3) overall and increased from the lower, middle, and upper tertile of genomic risk from 1.6 (0.5–5.4) to 2.5 (0.08–8.2) to 13.7 (3.8–67.3) respectively, and a p-value for interaction of 0.001.ConclusionsOur results suggest that genomic profile may modify the OC-associated ischemic stroke risk. Larger studies are warranted to determine whether a genomic risk score could be clinically useful in reducing OC-associated ischemic stroke.
Peptidomics approaches to the discovery and ACE inhibitory effect of casein peptides derived from fermented bovine milk by kefir grains
Authors: Wang Bo , Xiao Shan , Cai Yanxue , Chen Xuan , Wang Jihui 
Published: September 2023

IntroductionKefir grains with efficient proteolytic system is an excellent starter culture for the production of bioactive peptides and milk products. This study explores the casein peptides derived from fermented bovine milk by kefir grains using the peptidomics approaches. The angiotensin converting enzyme (ACE) inhibitory activity of these peptides were also investigated.MethodsAfter fermentation, peptidomics based on the LC-MS/MS was used to investigate the dynamic profile and the structure specificity of generated peptides. The ACE inhibitory activity of peptides was determined by measuring the amount of hippuric acid (HA) by a spectrophotometer at 228 nm.ResultsThe results indicated that the cell envelope proteinases (CEPs) were the PI-/PIII-type. A total of 122 peptides were identified. The β-casein was preferentially hydrolyzed by kefir grains, and the main hydrolysis regions were f57-93, f132-160 and f192-209. The αs1-, and κ-casein were also hydrolyzed by a weaker degree. In the process of fermentation, the accumulated peptides increased with the fermentation time. The fermentation products exhibited ACE inhibitory activity, and this bioactivity remained 63% after simulated gastrointestinal (GI) digestion in vitro. Additionally, 14 Pro-containing peptides with ACE inhibitory activity were also identified.ConclusionThese results provide new insights and evidence to investigate the bioactive milk peptides generated by kefir grains fermentation, as well as a reference for the development of functional foods.
Quelle langue pour leurs enfants ? Diola, français et wolof dans l'imaginaire d'adolescents diolas scolarisés
Authors: Moreau Marie-Louise 
Published: September 2023

Des adolescents diolas d'Oussouye, en Basse Casamance, placés dans des situations fictives, ont eu à opérer des choix impliquant le diola, le français et le wolof. Ils mobilisent divers types d'arguments, dans des proportions variables suivant les langues et les contrastes où elles figurent. Chacune des trois langues peut être caractérisée en termes des images auxquelles elle s’associe.
- Bien que les jeunes gens connaissent ses limitations géographiques, le diola bénéficie d'une image très favorable ; il est intimement lié au groupe et aux valeurs identitaires, qui s'exacerbent lorsqu'il est mis en contraste avec le wolof.
- Le français est associé au savoir, à l'école, à la promotion sociale ; on souligne aussi son extension ; il ne parait jouer aucun rôle dans la construction des identités.
- En ce qui concerne le wolof, les adolescents sont surtout sensibles à son extension ; pour le reste, ils font état, globalement, de sentiments assez ambivalents, certains le considérant comme plutôt prestigieux, d'autres émettant des opinions plus ou moins négatives.
Il ne semble guère avoir de pertinence identitaire. Dans l'ensemble, l'image du wolof est peu étoffée.
L'opposition conceptuelle entre instrumentalisme et sentimentalisme rend compte de l'économie générale de ces différentes associations.
Yetişkin Bireylerde Sürdürülebilir ve Sağlıklı Yeme Davranışları ile E-Sağlıklı Beslenme Okuryazarlığı ve Beslenme Bilgi Düzeyi Arasındaki İlişkinin Değerlendirilmesi
Authors: YEŞİLDEMİR Özge 
Published: September 2023

Giriş ve Amaç: Gelecek nesillere yaşanabilir bir dünya bırakmak için bireylerin sürdürülebilir ve sağlıklı beslenme davranışlarının arttırılması gerekmektedir. Bu çalışma, yetişkin bireylerin sürdürülebilir ve sağlıklı beslenme davranışları ile e-sağlıklı beslenme okuryazarlığı ve beslenme bilgi düzeyleri arasındaki ilişkinin değerlendirilmesi amacıyla yürütülmüştür.
Gereç ve Yöntemler: Araştırmanın örneklemini, yaşları 18-65 yıl arasında değişen 110 erkek ve 102 kadın olmak üzere toplam 222 birey oluşturmaktadır. Çalışma verileri anket aracılığıyla toplanmıştır. Bireylerin sürdürülebilir ve sağlıklı beslenme davranışlarını belirlemek amacıyla “Sürdürülebilir ve Sağlıklı Beslenme Davranışları Ölçeği”, elektronik sağlıklı beslenme okuryazarlık düzeyini değerlendirmek amacıyla “e-Sağlıklı Beslenme Okuryazarlık Ölçeği (e-SBO)” ve beslenme bilgi düzeyini belirlemek amacıyla “Yetişkinler için Beslenme Bilgi Düzeyi Ölçeği (YETBİD)” kullanılmıştır.
Bulgular: Kadınlarda sürdürülebilir ve sağlıklı beslenme davranışları ölçeği toplam puanı 4,0±1,05 ve erkeklerde 3,9±0,87’dir (p>0,05). Kadınların e-SBO düzeyleri (41,4±7,26) erkeklerden (38,6±7,20) daha yüksektir (p
Vazovagal Senkoplu Hastalarda Arteriel Sertlik ve Nabız Dalga Hızının Değerlendirilmesi
Authors: ALPASLAN Erkan , TAŞ Sedat , TAŞ Ümmü , OZPELIT Ebru 
Published: September 2023

Amaç: Çalışmamızın amacı Vazovagal senkoplu hastalarda hemodinamik mekanizmayı etkileyebilecek kardiyovasküler otonomik modülasyonlardan biri olan arteriyel sertlik parametrelerini değerlendirmek.
Gereç ve yöntemler: Çalışmamız retrospektif bir çalışmadır. Ocak 2012-Ocak 2016 tarihleri arasında kardiyoloji polikliniğine başvuran en az iki senkop atağı olan ve eğik masa testi pozitif olan 42 hastanın eğik masa testi sonuçlarını ve arteriyel sertlik parametrelerini topladık. Kontrol grubu olarak da yaş ve cinsiyete göre eşleştirilmiş 41 kişi aldık. Hastalardan damar özelliklerini etkileyebilecek durumları olan, ritim bozukluğu ve psikiyatrik bozukluğu olan hastaları çalışma dışı bıraktık. Hastaların arteriyel sertlik ölçümleri, tilt testi sonuçları, tıbbi öyküleri, sosyodemografik ve klinik bilgileri ile ilgili veriler tıbbi kayıtlarından elde edildi. Arteriyel sertliğinin belirteçleri olarak augmentasyon indeksi, merkezi nabız basıncı ve karotid ila radyal nabız dalga hızı dahil olmak üzere merkezi aort basıncı parametreleri elde edildi. Ardından 2 grup arasında değişkenler karşılaştırıldı.
Bulgular: Periferik sistolik (125 ± 16,6 ve 121,1 ± 14,9, p: 0,31) ve diyastolik kan basınçları (79,6 ± 8,9 ve 77,7 ± 9,7, p: 0,38) VVS ve kontrol grupları arasında benzerdi. Merkezi sistolik kan basınçları ve merkezi güçlendirme basınçları da gruplar arasında anlamlı farklılık göstermedi. Vazovagal senkoplu hastalarda nabız dalga hızı sağlıklı kontrollere göre anlamlı derecede düşüktü (5.4 (1.4) and 5.9 (1.8), p= 0.04). Aort augmentasyon indeksi gruplar arasında istatistiksel olarak farklı olmasa da hasta grubunda daha yüksek bulduk.
Sonuç: Çalışmamızda VVS grubunda nabız dalga yayılımı sağlıklı gruba göre daha düşük bulundu. Bu sonuçlar VVS hastalarında patofizyolojinin anlaşılmasına katkıda bulunabilir. Vazovagal senkoplu hastalarda nabız dalga hızının önemini anlamak için daha ileri çalışmalara ihtiyaç vardır.
Miocardiopatia Dilatada com evento cerebrovascular em paciente previamente hígido: relato de caso
Authors: Sena Michelle Bruna da Silva , Lemos Izabel Carminda de Mourão , Mourão Flávia da Costa , Reis Marcele Seixas , Da Silva Cristiane Santos , Oliveira John Elton Nascimento , Araújo Dayanne Lúcia de Souza 
Published: September 2023

A cardiomiopatia engloba as patologias que acometem o miocárdio acarretando alteração estrutural e funcional do órgão. Dentre essas patologias, encontramos a cardiomiopatia dilatada (CMD) na qual, há evidência de anormalidade na contração, no relaxamento miocárdico e disfunção ventricular. Possui várias etiologias, dentre elas, isquemia miocárdica, taquiarritmias, medicamentos, toxinas como o álcool, infecções, doenças autoimunes e doenças de depósito. As manifestações clínicas são variadas, desde um quadro assintomático com achado incidental de cardiomegalia até sinais e sintomas francos de insuficiência cardíaca. No caso relatado, temos um paciente previamente hígido que apresenta uma síndrome gripal, evoluindo com ortopneia e sintomas neurológicos com déficits focais ( hemiparesia à direita, disartria e diplopia ). A RM de crânio mostrou áreas de hipersinal nas regiões cerebelares, na ponte, bulbo e no mesencéfalo correspondendo à injúria vascular. Na radiografia de tórax, evidenciou-se uma área cardíaca aumentada e no ecocardiograma transtorácico, as câmaras cardíacas estavam aumentadas, além da fração de ejeção do VE estar reduzida denotando disfunção ventricular sistólica. O diagnóstico da CMD fora fechado com base nos achados dos exames complementares ( radiografia de tórax, ECG e ecocardiograma ) em virtude da história clínica ser muito mais composta de sinais e sintomas neurológicos e a provável etiologia seja a CMD induzida pelo álcool em virtude de o paciente possuir o hábito do consumo crônico e diário de bebida alcoólica por 21 anos.
Pandemia de COVID-19 e o impacto em crianças e adolescentes com transtornos alimentares: uma revisão de literatura
Authors: Ribeiro Matheus Rodrigues , Diniz Raphael Helvécio Carvalho de Oliveira , Azeredo Natália Silva , Cardoso Gabriel Sousa Dias , Ferreira Sofía Perroni , Viza Clara Leal Brum , Colnaghi Bárbara Sarnaglia , Araújo Paula Rosemar Macedo 
Published: September 2023

INTRODUÇÃO: A pandemia de COVID-19 trouxe inúmeras influências negativas para a saúde mental humana. Diversos sintomas e distúrbios psiquiátricos tiveram novos registros e exacerbações, incluindo os transtornos alimentares (TAs) na faixa pediátrica. OBJETIVO: Avaliar a influência da pandemia em crianças e adolescentes em relação aos TAs. MÉTODOS: Trata-se de uma revisão integrativa na base de dados PUBMED utilizando os descritores “pandemics AND eating disorders AND youth ‘’ para artigos publicados e 2020 e 2023. RESULTADOS: O isolamento causado pela pandemia de COVID-19, exacerbou sintomas e aumentou o número de internações por descompensação dos TAs. Muitos fatores foram associados a esse cenário, como o tempo ocioso, desregulação da rotina, aumento do uso de mídias, convívio domiciliar estressante e até mesmo outros distúrbios psiquiátricos como ansiedade e depressão. CONCLUSÃO: A pandemia teve impacto direto em crianças e adolescentes com diagnóstico de TAs, bem como incentivou o surgimento de sintomas em pacientes não diagnosticados anteriormente. Mais estudos devem ser feitos para identificar novos fatores de risco e realizar análises pós pandemia desse cenário.
Hidradenite supurativa, caracterização e tratamento: revisão de literatura
Authors: Passos Paulo Vitor , Kosloski Rejyane de Mattos Martins 
Published: September 2023

Introdução: A Hidradenite Supurativa (acne inversa) é uma doença crônica, inflamatória, que tem no diagnóstico precoce e abordagem adequada de tratamento as chaves da condição positiva de seu prognóstico. Objetivo: Esta revisão visa discutir a sua caracterização e abordagens de tratamento. Metodologia: Trata-se de uma revisão de literatura, com análise de artigos publicados entre os anos de 2016-2022, com o uso dos descritores hidradenite supurativa, dermatologia e tratamento (e respectivos termos em língua inglesa). Foram selecionadas 20 publicações de língua portuguesa e inglesa. Resultados e discussão: A Hidradenite Supurativa pode ser abordada eficazmente para a melhora da qualidade de vida e funcionalidade do paciente. Em geral, a abordagem da condição mescla medidas medicamentosas e não medicamentosas, com recursos selecionados ao paciente e cirurgia, especialmente de amplo espectro, aos casos refratários. Conclusão: Observou-se diferentes protocolos de tratamento que podem ser aplicados, mas o procedimento cirúrgico parece ser o que apresentou melhores resultados. Os casos de HS graves e refratários às medidas tópicas e menos invasivas, encontraram no tratamento cirúrgico uma abordagem efetiva aos dados decorrentes da condição, com a possibilidade de reparo estético associado e reincidência mínima à zona-alvo do procedimento, sobretudo se observada área ampla e extensa para melhor remissão.