bluuebunny/crossref_metadata_2025_split huggingface dataset:
Real change or more of the same? Analysing Australian media's portrayal of intellectual disability during the NDIS rollout
Authors: Winterbotham Sonya , Knight Bob G. , du Preez Jan 
Published: February 2023

AbstractBackgroundThrough the filtering of information, the creation, and reinforcement of stereotypes, media moulds attitudes and set agendas on critical social issues including public policy and disability.MethodsThis study explored Australian media representations of the care of people with intellectual disability during a crucial period in disability policy change: the National Disability Insurance Scheme (NDIS) rollout (2013–2018). Search criteria identified 168 news stories, examined via content analysis and news framing.ResultsFour major issues were identified: Roles and responsibilities of government; housing; mistreatment of persons with intellectual disability, and responsibility of care for families. Stories tended to be presented negatively, however, regional and local/community metropolitan stories were more balanced or positive compared with major metropolitan stories.ConclusionDespite significant disability policy change, media presentations continue to reinforce stereotypes of people with intellectual disability and position the government as one continuing to fall short in critical areas of funding, safety, and support.
A novel approach for developing left bundle branch pacing and left bundle branch block in a canine model
Authors: Hu Yiran , Cheng Sijing , He Pengkang , Huang Hao , Li Hui , Weng Sixian , Sun Xue Rong , Gu Min , Niu Hongxia , Liu Xi , Jin Han , Zhou Xiaohong , Hua Wei 
Published: February 2023

AbstractBackground and ObjectiveLeft bundle branch pacing (LBBP) has shown the benefits in the treatment of dyssynchronous heart failure (HF). The purpose of this study was to develop a novel approach for LBBP and left bundle branch block (LBBB) in a canine model.MethodsA “triangle‐center” method by tricuspid valve annulus angiography for LBBP implantation was performed in 6 canines. A catheter was then applied for retrograde His potential recording and left bundle branch (LBB) ablation simultaneously. The conduction system was stained to verify the “triangle‐center” method for LBBP and assess the locations of the LBB ablation site in relation to the left septal fascicle (LSF).ResultsThe mean LBB potential to ventricular interval and stimulus‐peak left ventricular activation time were 11.8 ± 1.2 and 35.7 ± 3.1 ms, respectively. The average intrinsic QRS duration was 44.7 ± 4.7 ms. LBB ablation significantly prolonged the QRS duration (106.3 ± 8.3 ms, p < .001) while LBBP significantly shortened the LBBB‐QRS duration to 62.5 ± 5.3 ms (p < .001). After 6 weeks of follow‐up, both paced QRS duration (63.0 ± 5.4 ms; p = .203) and LBBB‐QRS duration (107.3 ± 7.4 ms; p = .144) were unchanged when comparing to the acute phase, respectively. Anatomical analysis of 6 canine hearts showed that the LBBP lead‐tip was all placed in LSF area.ConclusionThe new approach for LBBP and LBBB canine model was stable and feasible to simulate the clinical dyssynchrony and resynchronization. It provided a useful tool to investigate the basic mechanisms of underlying physiological pacing benefits.
Astragaloside IV improves pulmonary arterial hypertension by increasing the expression of CCN1 and activating the ERK1/2 pathway
Authors: Liu Yu , Tang Bai‐Lin , Lu Mei‐Li , Wang Hong‐Xin 
Published: February 2023

AbstractThe aim of the present study was to investigate the underlying mechanism of AS‐IV and CCN1 in PAH and to evaluate whether the protective effect of AS‐IV against PAH is associated with CCN1 and its related signalling pathway. In vivo, male SD rats were intraperitoneally injected with monocrotaline (MCT, 60 mg/kg) or exposed to hypoxia (10% oxygen) and gavaged with AS‐IV (20, 40 and 80 mg/kg/day) to create a PAH model. In vitro, human pulmonary artery endothelial cells (hPAECs) were exposed to hypoxia (3% oxygen) or monocrotaline pyrrole (MCTP, 60 μg/mL) and treated with AS‐IV (10, 20 and 40 μM), EGF (10 nM, ERK agonist), small interfering CCN1 (CCN1 siRNA) and recombinant CCN1 protein (rCCN1, 100 ng/mL). We identified the differences in the expression of genes in the lung tissues of PAH rats by proteomics. At the same time, we dynamically detected the expression of CCN1 by Western blot both in vivo and in vitro. The Western blot experimental results showed that the expression of CCN1 increased in the early stage of PAH and decreased in the advanced stage of PAH. The results showed that compared with the control group, MCT‐ and hypoxia‐induced increased the hemodynamic parameters and apoptosis. AS‐IV can improve PAH, as characterized by decreased hemodynamic parameters, vascular wall area ratio (WA%), vascular wall thickness ratio (WT%) and α‐SMA expression and inhibition of cell apoptosis. Moreover, the improvement of PAH by AS‐IV was accompanied by increased CCN1 expression, which activated the ERK1/2 signalling pathway. Meanwhile, CCN1 and p‐ERK1/2 were inhibited by siCCN1 and promoted by rCCN1. EGF not only activated the ERK1/2 signalling pathway but also induced the expression of CCN1. In conclusion, AS‐IV improves PAH by increasing the expression of CCN1 and activating the ERK1/2 signalling pathway. The results of our study provide a theoretical basis for additional study on the protective effect of AS‐IV against PAH.
‘A Sovereign Europe’? Strategic Use of Discourse at the Service of French Economic Interests in EU Politics (2017–2022)
Authors: Bora Salih I. 
Published: February 2023

AbstractThe ‘practice turn’ in European Union (EU) studies has shown that everyday actions, notably discursive practices, are consequential for producing European integration. Yet, an important development has been overlooked by scholars: the emergence of a ‘European sovereignty’ discourse in EU politics. Since President Emmanuel Macron's Sorbonne speech in September 2017, the EU policy of the French government has been structured around the affirmed objective of building ‘European sovereignty’. It supposes that the EU should become more geopolitical and not shy away from defending its own interests in an increasingly disorderly and hostile world. This article enquires into the objectives that President Macron and the French government have sought to realise by introducing this discourse into EU politics. We argue that ‘European sovereignty’ is a discursive practice that instrumentalises security threats to the EU in order to legitimise France's economic policy objectives, most notably the reform of EU competition policy. Our findings derive not only from publicly available documents and speeches but also 72 semi‐directed interviews.
Towards a global perspective for Salvia L.: Phylogeny, diversification and floral evolution
Authors: Moein Fatemeh , Jamzad Ziba , Rahiminejad Mohammadreza , Landis Jacob B. , Mirtadzadini Mansour , Soltis Douglas E. , Soltis Pamela S. 
Published: February 2023

AbstractSalvia is the most species‐rich genus in Lamiaceae, encompassing approximately 1000 species distributed all over the world. We sought a new evolutionary perspective for Salvia by employing macroevolutionary analyses to address the tempo and mode of diversification. To study the association of floral traits with speciation and extinction, we modelled and explored the evolution of corolla length and the lever‐mechanism pollination system across our Salvia phylogeny. We reconstructed a multigene phylogeny for 366 species of Salvia in the broad sense including all major recognized lineages and 50 species from Iran, a region previously overlooked in studies of the genus. Our comprehensive sampling of Iranian species of Salvia provides higher phylogenetic resolution for southwestern Asian species than obtained in previous studies. Our phylogenetic data in combination with divergence time estimates were used to examine the evolution of corolla length, woody versus herbaceous habit, and presence versus absence of a lever mechanism. We investigated the timing and dependence of Salvia diversification related to corolla length evolution through a disparity test and BAMM analysis. A HiSSE model was used to evaluate the dependency of diversification on the lever‐mechanism pollination system in Salvia. A medium corolla length (15–18 mm) was reconstructed as the ancestral state for Salvia with multiple shifts to shorter and longer corollas. Macroevolutionary model analyses indicate that corolla length disparity is high throughout Salvia evolution, significantly different from expectations under a Brownian motion model during the last 28 million years of evolution. Our analyses show evidence of a higher diversification rate of corolla length for some Andean species of Salvia compared to other members of the genus. Based on our tests of diversification models, we reject the hypothesis of a direct effect of the lever mechanism on Salvia diversification. Therefore, we suggest caution in considering the lever‐mechanism pollination system as one of the main drivers of speciation in Salvia.
Trade‐off between pre and post‐copulatory traits depends on locomotor activity in male Tribolium castaneum beetles
Authors: Matsumura Kentarou 
Published: February 2023

AbstractLocomotor performance is an indicator of dynamic exercise; thus, it is a central trait in many animal behaviours. Although higher locomotor endurance may increase male reproductive success (e.g., in mate searching and male–male contests), investment in other male reproductive traits (e.g., male attractiveness and sperm competition) may be decreased through energy consumption due to higher activity levels. Here, I investigated male attractiveness, mating success, and paternity success using males of the red flour beetle Tribolium castaneum selected for higher (H) and lower (L) locomotor endurance. Although there was no difference in male attractiveness between the selection regimes, H males had significantly higher mating success than L males. Conversely, L males had significantly higher paternity success than H males. Therefore, there was a trade‐off between mating success and paternity success among the selection regimes, suggesting that locomotor endurance affects male reproduction in T. castaneum, and individual variation of locomotor endurance may be maintained within a population.
Molecular phylogeny of Spirotrichonymphea (Parabasalia) with emphasis on Spironympha, Spirotrichonympha, and three new genera Pseudospironympha, Nanospironympha, and Brugerollina
Authors: Noda Satoko , Kitade Osamu , Jasso‐Selles Daniel E. , Taerum Stephen J. , Takayanagi Miki , Radek Renate , Lo Nathan , Ohkuma Moriya , Gile Gillian H. 
Published: February 2023

AbstractSpirotrichonymphea, one of the six classes of phylum Parabasalia, are characterized by bearing many flagella in spiral rows, and they occur exclusively in the guts of termites. Phylogenetic relationships among the 13 described genera are not well understood due to complex morphological evolution and a paucity of molecular data. One such understudied genus is Spironympha. It has been variously considered a valid genus, a subgenus of Spirotrichonympha, or an “immature” life cycle stage of Spirotrichonympha. To clarify this, we sequenced the small subunit rRNA gene sequences of Spironympha and Spirotrichonympha cells isolated from the hindguts of Reticulitermes species and Hodotermopsis sjostedti and confirmed the molecular identity of H. sjostedti symbionts using fluorescence in situ hybridization. Spironympha as currently circumscribed is polyphyletic, with both H. sjostedti symbiont species branching separately from the “true” Spironympha from Reticulitermes. Similarly, the Spirotrichonympha symbiont of H. sjostedti branches separately from the “true” Spirotrichonympha found in Reticulitermes. Our data support Spironympha from Reticulitermes as a valid genus most closely related to Spirotrichonympha, though its monophyly and interspecific relationships are not resolved in our molecular phylogenetic analysis. We propose three new genera to accommodate the H. sjostedti symbionts and two new species of Spirotrichonympha from Reticulitermes.
Thermal and nonthermal sonication: Extraction of bioactive compounds from beet leaves and microbiological quality of extracts
Authors: Nutter Julia , Correa de Carvalho Màrcia , Zarbo Colombo Antonella Ailín , Jagus Rosa Juana , Agüero María Victoria 
Published: February 2023

AbstractThis work aimed to optimize a nonthermal (NT) ultrasound‐assisted aqueous extraction (aq‐UAE) to maximize the recovery of polyphenols, betaxanthins, and betacyanins. Extraction yields, thermal profiles and microbiological quality of the extract were compared with a previoulsy optimized thermal aq‐UAE. Extraction yields resulted 68%–121% higher in NT‐aqUAE. Polyphenols and betaxanthins were the most affected by high temperatures of thermal process showing decreses after 8 min of thermosonication at temperatures >50°C. Temperature during NT‐aqUAE waslower than 30ºC avoiding the detrimental effects of heat. Microbial counts decreased 2‐log cycles after thermosonication and the remaining microbial load did not resist the storage conditions. Conversely, no significant decreases were detected after NTaq‐UAE. However, sublethal damage was observed as microbial counts presented a higher lag phase than control during refrigerated storage. Although NTaq‐UAE process allows for higher phytochemical extraction yields than thermal aq‐UAE, it does not contribute to controlling the microbial load of extracts.Practical applicationNonthermal ultrasound‐assisted aqueous extraction of bioactive compounds from beet leaves was optimized in this work. This process improved the extraction yield of polyphenols and betalains compared with the thermal counterpart as thermolabile compounds degradation was avoided with the limitation on thermal increments. The developed process resulted simple and reasonably efficient for producing extracts rich in polyphenols and betalain pigments that hold potential to be used as natural additives. Additionally, evaluation of microbiological quality of extracts obtained by thermal and nonthermal optimized UAE processes allow to establish that thermal aq‐UAE improved microbiological quality and stability of extracts while nonthermal one would require an additional treatment of the extract to improve its microbiological quality. Developed processes are effective postharvest strategies to the valorisation of horticultural by products such as beet leaves and increase biomass utilization improving the sustainability of the agri‐food chain.
Introducing New Forms of Digital Money: Evidence from the Laboratory
Authors: CAMERA GABRIELE 
Published: February 2023

AbstractCentral banks may soon issue currencies that are entirely digital (CBDCs) and possibly interest bearing. A strategic analytical framework is used to investigate this innovation in the laboratory, contrasting a traditional “plain” tokens baseline to treatments with “sophisticated” interest‐bearing tokens. In the experiment, this theoretically beneficial innovation precluded the emergence of a stable monetary system, reducing trade and welfare. Similar problems emerged when sophisticated tokens complemented or replaced plain tokens. This evidence underscores the advantages of combining theoretical with experimental investigation to provide insights for payments systems innovation and policy design.
Self‐assessment of a breast care nursing model within a Breast Unit: learning process and keys to improving breast care
Authors: Rodriguez‐Ortega Ana , Ferro Tàrsila , Pérez Xavier , Pla Farnós Maria Jesus , Gil‐Gil Miguel , López Ojeda Anna , Borrás Josep María 
Published: February 2023

AbstractAim and objectivesTo assess the adherence of a nursing care model in a multidisciplinary breast cancer unit in a tertiary hospital to the recommended competencies and quality indicators.BackgroundAligning the competencies of the breast care nurse with international recommendations for this role helps better fulfil patient needs, increases satisfaction and ensures continuity of care.DesignCohort study.MethodsBreast care nursing was assessed in all patients treated at the Functional Breast Unit from 1 July 2016 to 30 June 2017. Patients were followed for 1 year. Sociodemographic, clinical and pathological data, treatments performed and nursing interventions were collected. The strobe checklist has been used to report this study.ResultsWe analysed nursing interventions carried out in 382 patients attended over 1 year in a multidisciplinary breast cancer unit. All patients with early disease had contact with the nurse at different times during their primary treatment. Only 58% of patients with advanced disease had contact with the nurse during their first year of illness. Moreover, first contact with the nurse was delayed by more than a week from diagnosis, the interval recommended by international guidelines.ConclusionThe nursing care model meets the core competencies defined for the breast care nurse in patients with early breast cancer, but the first visit should be organised earlier, and follow‐up should extend beyond completion of primary treatment.Relevance to clinical practiceThis study evaluated the breast care nurse model in one breast cancer unit according to international guidelines. Nursing care adhered to most guideline requirements in patients with early breast cancer, but not in those with advanced disease. New models of care need to be developed for women with advanced breast cancer in order to achieve true patient‐centred care.Patient or public contributionNo contribution from the patient or the public because the data collected was entered into the clinical history by the health professionals of the Breast Unit as part of their usual clinical practice.
Agreeableness and adolescents' cyberbullying perpetration: A longitudinal moderated mediation model of moral disengagement and empathy
Authors: Gao Ling , Li Xuan , Wang Xingchao 
Published: February 2023

AbstractObjectiveThe current study explored whether agreeableness predicted cyberbullying perpetration across 3 years and extended previous studies by exploring the mediating effect of moral disengagement and the moderating effects of empathy and gender.MethodThe participants included 2407 adolescents from 7 middle schools in China. They were recruited to complete the Big Five Personality Inventory, Bullying Scale and Empathy Scale at Time 1, Moral Disengagement Scale at Time 1 and Time 2, and Cyberbullying Perpetration Scale at Time 1, Time 2, and Time 3.ResultsAgreeableness at Time 1 predicted cyberbullying perpetration at Time 3 and moral disengagement at Time 2 mediated this relationship. The relationship between moral disengagement at Time 2 and cyberbullying perpetration at Time 3 was stronger for low cognitive empathy adolescents than high cognitive empathy adolescents at Time 1. The relationship between agreeableness at Time 1 and cyberbullying perpetration adolescents at Time 3 was stronger for low affective empathy than high affective empathy adolescents at Time 1. The link between moral disengagement at Time 2 and cyberbullying perpetration at Time 3 was weaker for females than males.ConclusionsLow agreeableness adolescents are more likely to use moral disengagement, which in turn leads to more cyberbullying perpetration.
Anthropocene in Context: A Response to Rasmussen
Authors: Hartman Laura M. 
Published: February 2023

ABSTRACTIn response to Larry Rasmussen's article about religious ethics in the Anthropocene, I offer an analysis that both contextualizes and elaborates upon his ideas. I introduce other humanities disciplines that have already wrestled with this question, and scholars of color whose voices offer needed correctives to the colonial heritage of most academic disciplines. I explore topics including human agency, non‐human agency, exploitation, and refuge. I encourage scholars in our field to move beyond questions of responsibility and lamentations of moral incompetence and into concepts of right relationality and analysis of grassroots climate action already taking place in religious, ethical contexts.
Protein interactomes for plant lipid biosynthesis and their biotechnological applications
Authors: Xu Yang , Singer Stacy D. , Chen Guanqun 
Published: February 2023

SummaryPlant lipids have essential biological roles in plant development and stress responses through their functions in cell membrane formation, energy storage and signalling. Vegetable oil, which is composed mainly of the storage lipid triacylglycerol, also has important applications in food, biofuel and oleochemical industries. Lipid biosynthesis occurs in multiple subcellular compartments and involves the coordinated action of various pathways. Although biochemical and molecular biology research over the last few decades has identified many proteins associated with lipid metabolism, our current understanding of the dynamic protein interactomes involved in lipid biosynthesis, modification and channelling is limited. This review examines advances in the identification and characterization of protein interactomes involved in plant lipid biosynthesis, with a focus on protein complexes consisting of different subunits for sequential reactions such as those in fatty acid biosynthesis and modification, as well as transient or dynamic interactomes formed from enzymes in cooperative pathways such as assemblies of membrane‐bound enzymes for triacylglycerol biosynthesis. We also showcase a selection of representative protein interactome structures predicted using AlphaFold2, and discuss current and prospective strategies involving the use of interactome knowledge in plant lipid biotechnology. Finally, unresolved questions in this research area and possible approaches to address them are also discussed.
PIF8‐WRKY42‐mediated salicylic acid synthesis modulates red light induced powdery mildew resistance in oriental melon
Authors: Wang Lixia , Wu Xutong , Xing Qiaojuan , Zhao Yaping , Yu Bo , Ma Yue , Wang Feng , Qi Hongyan 
Published: February 2023

AbstractLight signals and plant hormones are involved in regulating the growth, development and stress resistance of plants; however, it remains unclear whether light affects hormones and thus pathogen resistance in oriental melon. Here, we found that red light promoted salicylic acid (SA) accumulation and powdery mildew resistance by activating the transcription of CmICS, the key gene for SA biosynthesis, and silencing CmICS seriously weakened the induction effect of red light on powdery mildew resistance in oriental melon leaves. Further studies showed that red light induced the expression of CmWRKY42 under powdery mildew stress, and CmWRKY42 directly bound to the CmICS promoter to activate its expression and promote the accumulation of SA under red light. Furthermore, we found that PHYTOCHROME INTERACTING FACTOR 8 (PIF8), as a negative regulator of SA biosynthesis, inhibits CmWRKY42 transcriptional activation by binding to the CmWRKY42 promoter, and thus inhibits transcriptional activation of CmICS by CmWRKY42. Also, CmPIF8 binds to the CmICS promoter and directly inhibits its transcription. In conclusion, our study revealed a new molecular mechanism of the relationship between red light‐SA‐powdery mildew resistance and provided a theoretical basis for resistance breeding of oriental melon.
Simple transitive 2‐representations of Soergel bimodules for finite Coxeter types
Authors: Mackaay Marco , Mazorchuk Volodymyr , Miemietz Vanessa , Tubbenhauer Daniel , Zhang Xiaoting 
Published: February 2023

AbstractIn this paper, we show that Soergel bimodules for finite Coxeter types have only finitely many equivalence classes of simple transitive 2‐representations and we complete their classification in all types but and .