bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sense of power and markers of challenge and threat during extra‐dyadic problem discussions with romantic partners
Authors: Gresham Abriana M. , Peters Brett J. , Tudder Ashley , Simpson Jeffry A. 
Published: June 2023

AbstractPower, the capacity to influence others while resisting their attempts at influence, has implications for a wide variety of individual‐ and relationship‐level outcomes. One potential mechanism through which power may be associated with various outcomes is motivation orientation. High power has been linked to greater approach‐oriented motivation, whereas low power has been linked to greater avoidance‐oriented motivation. However, current research has mostly relied on artificially created relationships (and the power dynamics therein) in the lab to assess the associations between power and motivation orientations. Utilizing the Biopsychosocial Model of Challenge and Threat framework, the current study examined how power is related to physiological responses indicative of psychological challenge (i.e., approach) and threat (i.e., avoidance) during discussions of problems outside of the relationship between romantic partners. The primary hypothesis that higher power would be associated with more approach‐oriented challenge and less avoidance‐oriented threat was supported via self‐reports, but not via physiological assessments. Instead, physiological assessments revealed that for those disclosing problems to high‐power partners, greater power was associated with reactivity consistent with more avoidance‐oriented threat and less approach‐oriented challenge. This is the first research to examine associations between power and in vivo indices of challenge and threat during interactions between romantic partners. It advances our understanding of how power elicits motivation orientations and influences the stress response system by highlighting the importance of situational attributes (e.g., role during a conversation) that may undermine power during disclosures with a high‐power partner.
Concepts and measures of bureaucratic constraints in European Union laws from hand‐coding to machine‐learning
Authors: Franchino Fabio , Migliorati Marta , Pagano Giovanni , Vignoli Valerio 
Published: June 2023

AbstractScholars employ two main measures of the executive constraints embedded in European Union laws: one is based on the variation in the use of different types of restrictions, and the second is based on the frequency of such use. They reflect two alternative conceptualizations of bureaucratic control. We label them, respectively, as the “toolbox perspective” and the “design perspective”. We illustrate that the constraint frequency measure poses fewer validity problems in estimating legislators' intent to constrain implementation and tends to produce less severe measurement errors. We then evaluate the performance in estimating constraint variation of a recent computational application and identify potential drawbacks of automated learning from hand‐coded provisions. We lastly introduce a skeletal framework for a machine‐learning approach based on the syntactic structures employed by legislators that could improve the performance of this innovative technique.
A global experience‐sampling method study of well‐being during times of crisis: The CoCo project
Authors: Scharbert Julian , Reiter Thomas , Sakel Sophia , ter Horst Julian , Geukes Katharina , Gosling Samuel D. , Harari Gabriella , Kroencke Lara , Matz Sandra , Schoedel Ramona , Shani Maor , Stachl Clemens , Talaifar Sanaz , Aguilar Natalia M. A. , Amante Dayana , Aquino Sibele D. , Bastias Franco , Biesanz Jeremy C. , Bornamanesh Alireza , Bracegirdle Chloe , Campos Luís A. M. , Ceballos Maria C. , Chauvin Bruno , Choychod Sopa , Coetzee Nicoleen , Costin Vlad , Machado Gustavo d. S. , Dorfman Anna , dos Santos Monika , El‐Haddad Rita W. , Fajkowska Małgorzata , Gnisci Augusto , Hadjisolomou Stavros , Hale William W. , Katzir Maayan , Khechuashvili Lili , Kheirabadi Gholamreza , Kirchner‐Häusler Alexander , Göncü Köse Aslı , Kotzur Patrick Ferdinand , Kritzler Sarah , Lu Jackson G. , Martskvishvili Khatuna , Mottola Francesca , Obschonka Martin , Paolini Stefania , Perugini Marco , Rohmer Odile , Saeedian Yasser , Sarayuthpitak Jintana , Sczesny Sabine , Sergi Ida , Skimina Ewa , Talhelm Thomas , Tangdhanakanond Kamonwan , Tokat Tuluce , Torres Ana R. R. , Torres Claudio V. , Van Assche Jasper , Wolvaardt George G. , Yalçın Aslı , Bühner Markus , van Zalk Maarten , Back Mitja D. 
Published: June 2023

AbstractWe present a global experience‐sampling method (ESM) study aimed at describing, predicting, and understanding individual differences in well‐being during times of crisis such as the COVID‐19 pandemic. This international ESM study is a collaborative effort of over 60 interdisciplinary researchers from around the world in the “Coping with Corona” (CoCo) project. The study comprises trait‐, state‐, and daily‐level data of 7490 participants from over 20 countries (total ESM measurements = 207,263; total daily measurements = 73,295) collected between October 2021 and August 2022. We provide a brief overview of the theoretical background and aims of the study, present the applied methods (including a description of the study design, data collection procedures, data cleaning, and final sample), and discuss exemplary research questions to which these data can be applied. We end by inviting collaborations on the CoCo dataset.
How team clinical reasoning occurs on ward rounds: Implications for learning
Authors: Choi Justin J. , Contractor Jigar H. , Patel Vimla L. , Shapiro Martin F. 
Published: June 2023

AbstractBackgroundWard rounds offer a rich environment for learning about team clinical reasoning. We aimed to assess how team clinical reasoning occurs on ward rounds to inform efforts to enhance the teaching of clinical reasoning.MethodsWe performed focused ethnography of ward rounds over a 6‐week period, during which we observed five different teams. Each day team comprised one senior physician, one senior resident, one junior resident, two interns and one medical student. Twelve ‘night‐float’ residents who discussed new patients with the day team were also included. Field notes were analysed using content analysis.FindingsWe analysed 41 new patient presentations and discussions on 23 different ward rounds. The median duration of case presentations and discussions was 13.0 minutes (IQR, 10.0–18.0 minutes). More time was devoted to information sharing (median 5.5 minutes; IQR, 4.0–7.0 minutes) than any other activity, followed by discussion of management plans (median 4.0 minutes; IQR, 3.0–7.8 minutes). Nineteen (46%) cases did not include discussion of a differential diagnosis for the chief concern. We identified two themes relevant to learning: (1) linear versus iterative approaches to team‐based diagnosis and (2) the influence of hierarchy on participation in clinical reasoning discussions.ConclusionThe ward teams we observed spent far less time discussing differential diagnoses compared with information sharing. Junior learners such as medical students and interns contributed less frequently to team clinical reasoning discussions. In order to maximise student learning, strategies to engage junior learners in team clinical reasoning discussions on ward rounds may be needed.
Implementation of a molecular genotyping protocol for patients with warm autoantibodies
Authors: Blake Dorothy , Crews William S. , Wortman Sandy , Burnett‐Greenup Sarah , Walker LeeAnn 
Published: June 2023

AbstractBackgroundWarm autoantibodies (WAAs) cause delays and additional expenses while determining suitable products when using a traditional protocol (TP). In 2013, Carter BloodCare Immunohematology Reference Laboratory (IRL) introduced a molecular protocol (MP) for patients with WAAs.Study Design and MethodsRetrospective review of records for samples referred to the IRL from November 2004 to September 2020, was performed. Referrals, alloantibody(ies), gender, and age were recorded. Additionally, the count of common clinically significant antigens needed for phenotypically matched red blood cells (RBCs) were recorded for patients in MP. To further analyze charges and time spent testing patients with WAAs, 300 patients were selected.ResultsAnalysis of average charges to the referring hospital and time spent testing in the IRL determined savings at two or more referrals. Overall, 219 of 300 (73%) of patients in the study met or exceeded the number of referrals. Further analysis shows that while the population of patients with WAA (n = 300) shared similar demographics, there was a statistically significant difference between the average time testing patients in TP (M = 264.18, SD = 15.06) and MP (M = 156.00, SD = 90.37), t(157) = 14.46, p < .001, 95% confidence interval [CI] (93.41–122.97). Additionally, the assumption that each patient received two RBCs per referral provided no statistically significant difference between average charges to the hospitals of patients in TP (M = 1222.58, SD = 165.69) and MP (M = 1269.78, SD = 433.52), t(192) = −1.25, p = .214, 95% CI (−121.95–27.54).ConclusionThe MP has been effective in saving time spent testing patients with WAAs, which benefits referring hospitals, patients, and IRLs. Charges for prophylactic phenotypically matched blood were negligible and a MP would alleviate some of the current laboratory difficulties while providing safe products to patients.
Ring isomorphisms of type II∞$_\infty$ locally measurable operator algebras
Authors: Mori Michiya 
Published: June 2023

AbstractWe show that every ring isomorphism between the algebras of locally measurable operators for type II von Neumann algebras is similar to a real ‐isomorphism. This together with previous results by the author and Ayupov–Kudaybergenov completely describes ring isomorphisms between the algebras of locally measurable operators as well as lattice isomorphisms between the projection lattices for a general pair of von Neumann algebras without finite type I direct summands.
A Computational Pipeline for Patient-Specific Prediction of the Postoperative Mitral Valve Functional State
Authors: Liu Hao , Simonian Natalie T. , Pouch Alison M. , Iaizzo Paul A. , Gorman Joseph H. , Gorman Robert C. , Sacks Michael S. 
Published: June 2023

AbstractWhile mitral valve (MV) repair remains the preferred clinical option for mitral regurgitation (MR) treatment, long-term outcomes remain suboptimal and difficult to predict. Furthermore, pre-operative optimization is complicated by the heterogeneity of MR presentations and the multiplicity of potential repair configurations. In the present work, we established a patient-specific MV computational pipeline based strictly on standard-of-care pre-operative imaging data to quantitatively predict the post-repair MV functional state. First, we established human mitral valve chordae tendinae (MVCT) geometric characteristics obtained from five CT-imaged excised human hearts. From these data, we developed a finite-element model of the full patient-specific MV apparatus that included MVCT papillary muscle origins obtained from both the in vitro study and the pre-operative three-dimensional echocardiography images. To functionally tune the patient-specific MV mechanical behavior, we simulated pre-operative MV closure and iteratively updated the leaflet and MVCT prestrains to minimize the mismatch between the simulated and target end-systolic geometries. Using the resultant fully calibrated MV model, we simulated undersized ring annuloplasty (URA) by defining the annular geometry directly from the ring geometry. In three human cases, the postoperative geometries were predicted to 1 mm of the target, and the MV leaflet strain fields demonstrated close agreement with noninvasive strain estimation technique targets. Interestingly, our model predicted increased posterior leaflet tethering after URA in two recurrent patients, which is the likely driver of long-term MV repair failure. In summary, the present pipeline was able to predict postoperative outcomes from pre-operative clinical data alone. This approach can thus lay the foundation for optimal tailored surgical planning for more durable repair, as well as development of mitral valve digital twins.
Theoretical Analysis for Condensation Heat Transfer Performance Inside Converging-Shaped Microchannel Under Varying-Gravity Conditions
Authors: Bai Chao , Qiu Yan , Wei Min 
Published: June 2023

Abstract
The fast increasing heat-dissipation requirements under different working conditions such as varying gravity for aerospace industry is drawing more and more attention. Condensation inside microchannel is proved to be a promising technique to tackle this task. To comprehensively and accurately describe the physical phenomenon, a theoretical method considering both momentum exchange caused by vapor condensation and interface temperature drop is developed in this study. Reliability of our theoretical method is verified with both the Comprehensive Shah Correlation and established data. Condensation heat transfer inside converging-shaped microchannel is investigated and the influences of channel size, refrigerant mass flowrate, gravity variation, and converging angle are considered. Converging-shaped microchannel significantly enhances condensation heat transfer, especially for smaller channel with larger refrigerant mass flowrate. Influence of gravity change on condensation performances of vertically configured microchannels both with converging shape and constant cross-sectional area is small.
Berbamine promotes macrophage autophagy to clear
Mycobacterium tuberculosis
by regulating the ROS/Ca
2+
axis
Authors: Zhang Su , Zhou Xuefeng , Ou Min , Fu Xiangdong , Lin Qiao , Tao Xiaoyu , Wang Zhaoqin , Liu Aimei , Li Guobao , Xu Yuzhong , Zhang Guoliang 
Published: June 2023

ABSTRACT

Drug-resistant tuberculosis (TB) poses a major threat to global TB control; consequently, there is an urgent need to develop novel anti-TB drugs or strategies. Host-directed therapy (HDT) is emerging as an effective treatment strategy, especially for drug-resistant TB. This study evaluated the effects of berbamine (BBM), a bisbenzylisoquinoline alkaloid, on mycobacterial growth in macrophages. BBM inhibited intracellular
Mycobacterium tuberculosis
(Mtb) growth by promoting autophagy and silencing ATG5, partially abolishing the inhibitory effect. In addition, BBM increased intracellular reactive oxygen species (ROS), while the antioxidant
N
-acetyl-L-cysteine (NAC) abolished BBM-induced autophagy and the ability to inhibit Mtb survival. Furthermore, the increased intracellular Ca
2+
concentration induced by BBM was regulated by ROS, and BAPTA-AM, an intracellular Ca
2+
-chelating agent, could block ROS-mediated autophagy and Mtb clearance. Finally, BBM could inhibit the survival of drug-resistant Mtb. Collectively, these findings provide evidence that BBM, a Food and Drug Administration (FDA)–approved drug, could effectively clear drug-sensitive and -resistant Mtb through regulating ROS/Ca
2+
axis-mediated autophagy and has potential as an HDT candidate for TB therapy.

IMPORTANCE

It is urgent to develop novel treatment strategies against drug-resistant TB, and HDT provides a promising approach to fight drug-resistant TB by repurposing old drugs. Our studies demonstrate, for the first time, that BBM, an FDA-approved drug, not only potently inhibits intracellular drug-sensitive Mtb growth but also restricts drug-resistant Mtb by promoting macrophage autophagy. Mechanistically, BBM activates macrophage autophagy by regulating the ROS/Ca
2+
axis. In conclusion, BBM could be considered as an HDT candidate and may contribute to improving the outcomes or shortening the treatment course of drug-resistant TB.
Restriction of SARS-CoV-2 replication by receptor transporter protein 4 (RTP4)
Authors: Kaur Ramanjit , Tada Takuya , Landau Nathaniel Roy 
Published: June 2023

ABSTRACT
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is subject to restriction by several interferon-inducible host proteins. To identify novel factors that limit replication of the virus, we tested a panel of genes that we found were induced by interferon treatment of primary human monocytes by RNA sequencing. Further analysis showed that one of the several candidates genes tested, receptor transporter protein 4 (RTP4), that had previously been shown to restrict flavivirus replication, prevented the replication of the human coronavirus HCoV-OC43. Human RTP4 blocked the replication of SARS-CoV-2 in susceptible ACE2.CHME3 cells and was active against SARS-CoV-2 Omicron variants. The protein prevented the synthesis of viral RNA, resulting in the absence of detectable viral protein synthesis. RTP4 bound the viral genomic RNA and the binding was dependent on the conserved zinc fingers in the amino-terminal domain. Expression of the protein was strongly induced in SARS-CoV-2-infected mice although the mouse homolog was inactive against the virus, suggesting that the protein is active against another virus that remains to be identified.

IMPORTANCE
The rapid spread of a pathogen of human coronavirus (HCoV) family member, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), around the world has led to a coronavirus disease 2019 (COVID-19) pandemic. The COVID-19 pandemic spread highlights the need for rapid identification of new broad-spectrum anti-coronavirus drugs and screening of antiviral host factors capable of inhibiting coronavirus infection. In the present work, we identify and characterize receptor transporter protein 4 (RTP4) as a host restriction factor that restricts coronavirus infection. We examined the antiviral role of hRTP4 toward the coronavirus family members including HCoV-OC43, SARS-CoV-2, Omicron BA.1, and BA.2. Molecular and biochemical analysis showed that hRTP4 binds to the viral RNA and targets the replication phase of viral infection and is associated with reduction of nucleocapsid protein. Significant higher levels of ISGs were observed in SARS-CoV-2 mouse model, suggesting the role of RTP4 in innate immune regulation in coronavirus infection. The identification of RTP4 reveals a potential target for therapy against coronavirus infection.
A dynamic epibiont community associated with the bone-eating polychaete genus
Osedax
Authors: Goffredi Shana K. , Panossian Balig , Brzechffa Camille , Field Naomi , King Chad , Moggioli Giacomo , Rouse Greg W. , Martín-Durán José M. , Henry Lee M. 
Published: June 2023

ABSTRACT

Osedax,
the deep-sea annelid found at sunken whalefalls, is known to host Oceanospirillales bacterial endosymbionts intracellularly in specialized roots, which help it feed exclusively on vertebrate bones. Past studies, however, have also made mention of external bacteria on their trunks. During a 14-yr study, we reveal a dynamic, yet persistent, shift of Campylobacterales integrated into the epidermis of
Osedax
, which change over time as the whale carcass degrades on the sea floor. The Campylobacterales associated with seven species of
Osedax
, which comprise 67% of the bacterial community on the trunk, appear initially dominated by the genus
Arcobacter
(at early time points <24 mo), the
Sulfurospirillum
at intermediate stages (~50 mo), and the
Sulfurimonas
at later stages (>140 mo) of whale carcass decomposition. Metagenome analysis of the epibiont metabolic capabilities suggests potential for a transition from heterotrophy to autotrophy and differences in their capacity to metabolize oxygen, carbon, nitrogen, and sulfur. Compared to free-living relatives, the
Osedax
epibiont genomes were enriched in transposable elements, implicating genetic exchange on the host surface, and contained numerous secretions systems with eukaryotic-like protein (ELP) domains, suggesting a long evolutionary history with these enigmatic, yet widely distributed deep-sea worms.

IMPORTANCE
Symbiotic associations are widespread in nature and we can expect to find them in every type of ecological niche. In the last twenty years, the myriad of functions, interactions and species comprising microbe-host associations has fueled a surge of interest and appreciation for symbiosis. During this 14-year study, we reveal a dynamic population of bacterial epibionts, integrated into the epidermis of 7 species of a deep-sea worm group that feeds exclusively on the remains of marine mammals. The bacterial genomes provide clues of a long evolutionary history with these enigmatic worms. On the host surface, they exchange genes and appear to undergo ecological succession, as the whale carcass habitat degrades over time, similar to what is observed for some free-living communities. These, and other annelid worms are important keystone species for diverse deep-sea environments, yet the role of attached external bacteria in supporting host health has received relatively little attention.
Differentiating glaucoma from chiasmal compression using optical coherence tomography: the macular naso-temporal ratio
Authors: Kleerekooper Iris , Wagner Siegfried K , Trip S Anand , Plant Gordon T , Petzold Axel , Keane Pearse A , Khawaja Anthony P 
Published: June 2023

Background/aimsThe analysis of visual field loss patterns is clinically useful to guide differential diagnosis of visual pathway pathology. This study investigates whether a novel index of macular atrophy patterns can discriminate between chiasmal compression and glaucoma.MethodsA retrospective series of patients with preoperative chiasmal compression, primary open-angle glaucoma (POAG) and healthy controls. Macular optical coherence tomography (OCT) images were analysed for the macular ganglion cell and inner plexiform layer (mGCIPL) thickness. The nasal hemi-macula was compared with the temporal hemi-macula to derive the macular naso-temporal ratio (mNTR). Differences between groups and diagnostic accuracy were explored with multivariable linear regression and the area under the receiver operating characteristic curve (AUC).ResultsWe included 111 individuals (31 with chiasmal compression, 30 with POAG and 50 healthy controls). Compared with healthy controls, the mNTR was significantly greater in POAG cases (β=0.07, 95% CI 0.03 to 0.11, p=0.001) and lower in chiasmal compression cases (β=−0.12, 95% CI −0.16 to –0.09, p<0.001), even though overall mGCIPL thickness did not discriminate between these pathologies (p=0.36). The mNTR distinguished POAG from chiasmal compression with an AUC of 95.3% (95% CI 90% to 100%). The AUCs when comparing healthy controls to POAG and chiasmal compression were 79.0% (95% CI 68% to 90%) and 89.0% (95% CI 80% to 98%), respectively.ConclusionsThe mNTR can distinguish between chiasmal compression and POAG with high discrimination. This ratio may provide utility over-and-above previously reported sectoral thinning metrics. Incorporation of mNTR into the output of OCT instruments may aid earlier diagnosis of chiasmal compression.