bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of Novel Wide-Field In Vivo Corneal Confocal Microscopy With Skin Biopsy for Assessing Peripheral Neuropathy in Type 2 Diabetes
Authors: Badian Reza A. , Ekman Linnéa , Pripp Are Hugo , Utheim Tor Paaske , Englund Elisabet , Dahlin Lars B. , Rolandsson Olov , Lagali Neil 
Published: April 2023

Diabetic peripheral neuropathy (DPN) is a serious complication of diabetes, where skin biopsy assessing intraepidermal nerve fiber density (IENFD) plays an important diagnostic role. In vivo confocal microscopy (IVCM) of the corneal subbasal nerve plexus has been proposed as a noninvasive diagnostic modality for DPN. Direct comparisons of skin biopsy and IVCM in controlled cohorts are lacking, as IVCM relies on subjective selection of images depicting only 0.2% of the nerve plexus. We compared these diagnostic modalities in a fixed-age cohort of 41 participants with type 2 diabetes and 36 healthy participants using machine algorithms to create wide-field image mosaics and quantify nerves in an area 37 times the size of prior studies to avoid human bias. In the same participants, and at the same time point, no correlation between IENFD and corneal nerve density was found. Corneal nerve density did not correlate with clinical measures of DPN, including neuropathy symptom and disability scores, nerve conduction studies, or quantitative sensory tests. Our findings indicate that corneal and intraepidermal nerves likely mirror different aspects of nerve degeneration, where only intraepidermal nerves appear to reflect the clinical status of DPN, suggesting that scrutiny is warranted concerning methodologies of studies using corneal nerves to assess DPN.

Article Highlights
Comparison of intraepidermal nerve fiber density with automated wide-field corneal nerve fiber density in participants with type 2 diabetes revealed no correlation between these parameters. Intraepidermal and corneal nerve fibers both detected neurodegeneration in type 2 diabetes, but only intraepidermal nerve fibers were associated with clinical measures of diabetic peripheral neuropathy. A lack of association of corneal nerves with peripheral neuropathy measures suggests that corneal nerve fibers may be a poor biomarker for diabetic peripheral neuropathy.
Higher Sensory Cortical Energy Metabolism in Painful Diabetic Neuropathy: Evidence From a Cerebral Magnetic Resonance Spectroscopy Study
Authors: Sloan Gordon , Anton Adriana , Caunt Sharon , Wilkinson Iain , Selvarajah Dinesh , Tesfaye Solomon 
Published: April 2023

Alterations in the resting-state functional connectivity and hyperperfusion of pain processing areas of the brain have been demonstrated in painful diabetic peripheral neuropathy (DPN). However, the mechanisms underlying these abnormalities are poorly understood; thus there is good rationale to explore whether there is higher energy consumption in the pain processing areas of the brain. We performed a 31P magnetic resonance spectroscopy study to explore cellular energy usage (bioenergetics) in the primary somatosensory (S1) cortex in a well-characterized cohort of participants with painful and painless DPN. S1 phosphocreatine (PCr):ATP, a measure of energy consumption, was significantly reduced in painful compared with painless DPN. This is indicative of greater S1 cortical energy consumption in painful DPN. Furthermore, S1 PCr:ATP correlated with pain intensity during the MRI. S1 PCr:ATP was also significantly lower in painful-DPN individuals with moderate/severe pain compared with those with low pain. To our knowledge, this is the first study to demonstrate higher S1 cortical energy metabolism in painful compared with painless DPN. Moreover, the relationship between PCr:ATP and neuropathic pain measures shows that S1 bioenergetics is related to the severity of neuropathic pain. S1 cortical energetics may represent a biomarker of painful DPN and could have the potential to serve as a target for therapeutic interventions.

Article Highlights
Energy consumption within the primary somatosensory cortex appears to be greater in painful compared with painless diabetic peripheral neuropathy. The measure of energy metabolism, PCr:ATP, within the somatosensory cortex correlated with pain intensity and was lower in those with moderate/severe compared with low pain. To our knowledge. this is the first study to indicate higher cortical energy metabolism in painful compared with painless diabetic peripheral neuropathy, and thus has the potential to act as a biomarker for clinical pain trials.
Risk of Type 1 Diabetes in Children Is Not Increased After SARS-CoV-2 Infection: A Nationwide Prospective Study in Denmark
Authors: Noorzae Rohina , Junker Thor Grønborg , Hviid Anders Peter , Wohlfahrt Jan , Olsen Sjurdur Frodi 
Published: April 2023

OBJECTIVE
It has been hypothesized that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in children can increase risk of developing type 1 diabetes.

RESEARCH DESIGN AND METHODS
We undertook a prospective, register-based analysis of children in Denmark by investigating the association between SARS-CoV-2 infection and subsequent risk of type 1 diabetes. During the pandemic, Denmark had one of the highest test rates per capita in the world, and 90% of all Danish children were tested.

RESULTS
Compared with children with a history of only negative SARS-CoV-2 tests, we did not observe a higher risk of first-time diagnosis of type 1 diabetes in children 30 days or more after a positive SARS-CoV-2 test (hazard ratio 0.85; 95% CI 0.70–1.04).

CONCLUSIONS
Our data do not support that SARS-CoV-2 infection is associated with type 1 diabetes or that type 1 diabetes should be a special focus after a SARS-CoV-2 infection in children.
What Does a New Health Technology Landscape Mean for Hispanic/Latino People With Diabetes?
Authors: Rodriguez Jorge A. , Seiglie Jacqueline Anne , Caballero Augusto Enrique 
Published: April 2023

<p> </p>
<p>Despite advances in type 2 diabetes management, disparities persist among Latinos living in the United States. Latinos, the fastest-growing ethnic minority population in the United States, are twice as likely to have diabetes-related complications and 1.3 times more likely to die from diabetes than non-Latino Whites (1). These inequities are driven by a complex interplay of biological, social, structural, and health system factors, including difficulty navigating the health care system (2,3). For example, Latinos have higher no-show rates to clinic visits and have lower rates of medication adherence than non-Latino Whites (4,5). These persistent disparities demand innovation. </p>
Higher sensory cortical energy metabolism in Painful-Diabetic Neuropathy: evidence from a cerebral Magnetic Resonance Spectroscopy study
Authors: Sloan Gordon , Anton Adriana , Caunt Sharon , Wilkinson Iain , Selvarajah Dinesh , Tesfaye Solomon 
Published: April 2023

<p> </p>
<p>Alterations in the resting state functional connectivity and hyperperfusion of pain processing areas of the brain have been demonstrated in painful-Diabetic Peripheral Neuropathy (DPN). However, the mechanisms underlying these abnormalities are poorly understood. There is thus a good rationale to explore if there is higher energy consumption in the pain processing areas of the brain.</p>
<p>We performed a 31Phosphorus Magnetic Resonance Spectroscopy (31P-MRS) study to explore cellular energy usage (bioenergetics) in the primary somatosensory (S1) cortex in a well-characterised cohort of participants with painful- and painless-DPN. </p>
<p>S1 PCr:ATP, a measure of energy consumption, was significantly reduced in painful- compared with painless-DPN. This is indicative of greater S1 cortical energy consumption in painful-DPN. Furthermore, S1 PCr:ATP correlated with pain intensity during the MRI. S1 PCr:ATP was also significantly lower in painful-DPN individuals with moderate/severe pain compared to those with low pain.</p>
<p>This is the first study to demonstrate higher S1 cortical energy metabolism in painful- compared with painless-DPN. Moreover, the relationship between PCr:ATP and neuropathic pain measures shows that S1 bioenergetics is related to the severity of neuropathic pain. S1 cortical energetics may represent a biomarker of painful-DPN and could have the potential to serve as a target for therapeutic interventions.</p>
Dysregulation of CXCL1 expression and neutrophil recruitment in insulin resistance and diabetes-related periodontitis in male mice
Authors: Shinjo Takanori , Onizuka Satoru , Zaitsu Yumi , Ishikado Atsushi , Park Kyoungmin , Li Qian , Yokomizo Hisashi , Zeze Tatsuro , Sato Kohei , St-Louis Ronald , Fu Jialin , I-Hsien Wu , Mizutani Koji , Hasturk Hatice , E Van Dyke Thomas , Nishimura Fusanori , L King George 
Published: April 2023

<p> </p>
<p>Insulin resistance and hyperglycemia are risk factors for periodontitis and poor wound healing in diabetes, which have been associated with selective loss of insulin- activation of the PI3K/Akt pathway in the gingiva. This study showed that insulin resistance in the mouse gingiva due to selective deletion of smooth muscle and fibroblast insulin receptor (SMIRKO mice) or systemic metabolic changes induced by high fat diet (HFD) in HFD-fed mice exacerbated periodontitis-induced alveolar bone loss, preceded by delayed neutrophil and monocyte recruitment and impaired bacterial clearance compared to their respective controls. The immunocytokines, CXCL1, CXCL2, MCP-1, TNFα, IL-1β and IL-17A exhibited delayed maximal expression in the gingiva of male SMIRKO and HFD-fed mice compared to controls. Targeted overexpression of CXCL1 in the gingiva by adenovirus normalized neutrophil and monocyte recruitment and prevented bone loss in both mouse models of insulin resistance. Mechanistically, insulin enhanced bacterial lipopolysaccharide-induced CXCL1 production in mouse and human gingival fibroblasts (GFs), via Akt pathway and NF-κB activation, which were reduced in GFs from SMIRKO and HFD-fed mice. These results provided the first report that insulin signaling can enhance endotoxin induced CXCL1 expression to modulate neutrophil recruitment, suggesting CXCL1 as a new therapeutic direction for periodontitis or wound healing in diabetes. </p>
General theoretical analysis of legal security of business activity
Authors: Kovalenko І. 
Published: April 2023

Effective legal means of regulating relations between business entities and preventing violations of the latter's rights and interests protected by law include compliance by the participants of business relations, including business entities, state authorities, etc., with the requirements of current legislation. That is, such a legal regime is desirable, within which the best way to protect the rights of business entities is to prevent violations of the rights of these entities and, as a result, the absence of the very need to renew rights.
It is clear that such a preventive influence on the behavior of business entities is the result not only of the conscientious behavior of the participants in economic relations, but, most likely, the consequence of the regulatory influence on the behavior of these entities of the norms of current legislation, which contains binding, prohibitive and other legal prescriptions (requirements), the existence of which is aimed at preventing violations of the rights and legally protected interests of business entities and restoring these rights and interests in cases of their violation, non-recognition or dispute.
The need to protect subjective rights and interests arises primarily in connection with illegal behavior. However, protection can also take place in the event of a threat of violation of the right in the future, which may not always be considered illegal behavior.
The threat may arise due to the actions of the right holder himself, for example, in connection with the loss of the corresponding document. Defense is also allowed in case of violation of interest by non-illegal behavior. A person can apply to the court for protection in the event of a conflict between his interests and the interests of other participants in the legal relationship, and even when the behavior of each of them is lawful.
The subject of research in the article is specific norms of constitutional, civil, economic and administrative law, which establish legal guarantees of ensuring and protecting entrepreneurial activity by the norms of national law.
Online mediation: international experience and prospects for implementation in Ukraine
Authors: Bondarchuk N. , Radchenko O. 
Published: April 2023

The article discusses the problems of online mediation in Ukraine. The article analyzes the legislative regulation of mediation. As well as the use of online methods for the lawsuits resolution, which can significantly reduce the burden on the judicial system and ensure access to justice for all citizens under martial law and pandemic conditions (COVID-19). In the context of the pandemic, the introduction of online mediation becomes especially relevant, as it aims not only to simplify the process of lawsuits resolution, but also to ensure the preservation of citizens’ health. «The guidelines for preparing and conducting online mediation" adopted by the CA "NAMU" were analyzed. Created by the professional community of mediators as a response to the challenges that arise in the daily legal professional activities of mediators, such as: new circumstances, lack of legislation, etc. And distributed in order to provide support for safe professional practice. Determined the main factors of the prospects for the rapid development of alternative lawsuits resolution methods under digitalization and martial law in Ukraine.
An analysis of the international legal regulation of online mediation has been carried out. It has been researched that the European legal system is aimed at encouraging the parties in lawsuits to use proper legal procedures to resolve the legal dispute, but not only in court. An analysis of the challenges of online mediation, which the mediator and participants face when conducting mediation in this format, has been carried out, as well as the advantages and disadvantages of online mediation in Ukraine have been determined. The ethical principles for online lawsuits resolution are set to find a wider audience as stakeholders in ODR systems become more expansive and inclusive. Different ways to improve the legislative regulation of online mediation by making additions to the Law of Ukraine "Mediation" are proposed.
Legal security for employer monitoring of employee use of corporate email, internet resources, and computer technology in the United States of America
Authors: Lutsenko O. 
Published: April 2023

The article covers issues of the protection of employees’ personal data, and problems of monitoring by employers of the use of corporate e-mails, business accounts, computers and other devices of the employer.
The author rightly notes that now almost any software allows for computer monitoring and monitoring of the workplace even without the knowledge of employees, and the current legislation does not oblige employers to notify employees before implementing such monitoring software. However, in many states, such legislation exists and case law has been developed to protect the rights of employees in the event
In the US, it is common practice for employers to monitor e-mail or Internet use without warning, threatening the basic rights of American workers. In the US, companies put forward many reasons for monitoring the use of corporate e-mail or the Internet, in particular: a) prevention of improper (non-intended) use of corporate e-mail, loss of efficiency of employees’ work on the Internet; b) network policy of the company; c) prevention of lawsuits about discrimination, harassment or other offenses on the Internet; d) prevention of unauthorized transfer of intellectual property and avoidance of illegal copies of copyrighted materials by employees; e) preservation of company documentation; e) prevention of illegal appropriation of personal information, potential spam or “virus programs”; g) protection of the company’s assets, including intellectual property and business plans
The author also analyzes the problem of what steps the company takes to limit the use of corporate computers for personal use by employees.
A growing number of American companies are monitoring their employees’ e-mail and Internet communications to reduce the risk of employee wrongdoing. Computer systems provided by an employer but misused by employees may lead to claims of discrimination or sexual harassment or to the distribution of offensive e-mail or Internet graphics, messages, defamation, copyright infringement, fraud, or even become the basis for lawsuits related to employee misconduct. In addition, e-mail jokes or crude screenplays can also expose an employer to a harassment claim.
Towards an understanding of how a higher education institution can enhance the impact of social enterprises through incubation
Authors: Lepik Katri-Liis , Sakarias Eliisa 
Published: April 2023

Abstract
Social entrepreneurship is a relatively new concept in Estonia and measuring the social impact of enterprises is not yet the norm. It has gained more awareness during recent years and therefore several support instruments have been established. The aim of the paper is to provide a framework for impact analysis of an incubator and analysis of the evaluation of the program for social enterprises according to the designed framework. The incubation program itself was piloted at a higher education institution. The paper addresses the concept of social enterprises, new social venture creation, incubation by a higher education institution and its impact on social enterprises. While the development of enterprises is a common topic, the research on social impact incubators is still scarce. The study is characterised by a descriptive and an exploratory study design. The paper explores the social enterprise incubator through mixed-method two-stage content analysis of the applications and self-analysis reports of the participants of the incubator. In the process of the content analysis, qualitative data analysis is used. Finally, the paper concludes that the incubator was successful as it helped the social enterprises to become sustainable and enhanced their social impact. The limitation of the research is the evaluation design which addresses measuring the successfulness of the incubation immediately after the end of the programme and not in the long-term. The study contributes to the literature on measuring the successfulness of incubation processes and on the practice of incubating new social ventures with social impact.
PENGARUH SUISTAINABILITY AWARENESS TERHADAP NILAI PERUSAHAAN
Authors: Sembiring Jeremy Reynara Binoto Persada , Anis Idrianita 
Published: April 2023

Penelitian ini memiliki tujuan untuk menganalisis pengaruh suistainability awareness terhadap nilai perusahaan pada perusahaan properti dan real estate yang terdaftar di Bursa Efek Indonesia periode 2016-2020. Metode penelitian ini adalah analisis uji hipotesis, data yang digunakan data sekunder yang berupa laporan keuangan dan laporan tahunan. Teknik pengumpulan sampel menggunakan metode purposive sampling yang diperoleh 12 perusahaan dengan data sebanyak 60 sampel.
Penelitian ini menggunakan metode analisis regresi data panel dengan hasil penelitian menunjukan bahwa overall suistainability awareness dan suistainability intention tidak berpengaruh terhadap nilai perusahaan, suistainability integration berpengaruh positif dan signifikan terhadap nilai perusahaan, dan suistainability implementation berpengaruh negatif dan signifikan terhadap nilai perusahaan .
PENGARUH KINERJA KEUANGAN DAN RISIKO BISNIS DENGAN STRUKTUR MODAL SEBAGAI VARIABLE INTERVENING TERHADAP NILAI PERUSAHAAN
Authors: Farah Nur Azizah  , Firdayetti  
Published: April 2023

Tujuan dari riset berikut ialah untuk menganalisis serta memperoleh hasil profitabilitas, arus kas serta kerugian dalam bisnis pada laba perusahaan serta perubahan struktur keuangan. Riset berikut adalah penelitian analisis kuantitatif dengan menggunakan metode deskriptif. Populasi riset berikut ialah seluruh perusahaan transportasi serta logistik yang terdata di Bursa Efek Indonesia periode 2019-2021. Metode pengambilan sampel yang digunakan ialah purposive sampling serta metode penelitian yang digunakan dalam riset berikut ialah analisis linier berganda, pengujian hipotesis klasik serta pengujian hipotesis menggunakan program Statistical Package for Social Sciences (SPSS) versi 22 untuk menguji hipotesis. Hasil riset berikut menunjukkan bahwa pengaruh laba, modal keuangan serta resiko/kerugian usaha berpengaruh significant terhadap laba perusahaan melalui perencanaan keuangan, sedangkan laba, modal keuangan serta resiko/kerugian usaha tidak berpengaruh langsung
ANALISIS FAKTOR PENGARUH KEPUTUSAN PEMBELIAN KOPI KENANGAN OLEH MAHASISWA EKONOMI PEMBANGUNAN UNIVERSITAS TRISAKTI
Authors: Assadin Savero Demas , Syafri  , Nurhayati  
Published: April 2023

Dengan maraknya bisnis coffeeshop khususnya di Jakarta dan sekitar, semenjak pandemi Covid 19 juga menjadi tren istilah WFC atau Work From Café tidak hanya dari kalangan pekerja tetapi dari kalangan mahasiswa juga menggemari kopi kekinian seperti ini. Maka dari itu tujuan dari penelitian ini adalah untuk mengetahui pengaruh Produk, Harga, Promosi, Pelayanan, dan Lokasi terhadap keputusan pembelian kopi kenangan oleh Mahasiswa Ekonomi Pembangunan di Universitas Trisakti. Populasi Mahasiswa Ekonomi Pembangunan sebanyak 150. Sampel untuk penelitian ini sebanyak 85 responden,. Metode yang digunakan adalah Structural Equation Modeling Partial Least Square (SEM PLS). Berdasarkan hasil penelitian diperoleh bahwa variabel harga dan promosi berpengaruh terhadap keputusan pembelian produk kopi kenangan. Sedangkan variabel produk, pelayanan, dan lokasi tidak berpengaruh terhadap keputusan pembelian produk kopi kenangan.
PENGARUH PRODUK, CITRA MEREK, PERIKLANAN, HARGA, DAN KUALITAS PELAYANAN TERHADAP KEPUTUSAN PEMBELIAN POLIS ASURANSI KESEHATAN
Authors: Sudiar Dendy Ovary , Mandai Syafri , Nurhayati  , Santosa Budi 
Published: April 2023

Tujuan yang ingin dicapai di dalam penelitian ini adalah untuk mengetahui pengaruh citra merek periklanan harga dan kualitas pelayanan terhadap keputusan pembelian polis asuransi kesehatan yang dilakukan oleh konsumen, untuk sampel untuk penelitian ini adalah 151 responden, sampel penelitianya dari kalangan masyarakat umum dan metode yang digunakan adalah SmartPLS, Hasil peneliatian menunjukan bahwa adanya pengaruh variable citra merek, produk iklan, dan kualitas pelayanan terhadap keputusan pembelian polis asuransi kesehatan, metode penelitian yang digunakan menjelaskan hubungan antara variable dengan menganlisis, menguji hipotesa yang diketahui, dan menjelaskan hubungan antara variable bebas yaitu produk, citra merek, periklanan, harga, kualitas pelayanan dan keputusan pembelian Penelitian ini menunjukan bahwa adanya pengaruh yang signifikan terhadap variable citra merek,kualitas pelayanan dan iklan terhadap keputusan pembelian, dan untuk variable harga tidak berepengaruh terhadap keputusan pembelian