bluuebunny/crossref_metadata_2025_split huggingface dataset:
Drug-Drug Interaction Intensity Differences Depending On The Hematopoietic Stem Cell Transplantation Type And Existing Polypharmacy Prior To Transplantation
Authors: GÜNAY Ayşe , DEMİRPOLAT Eren , AYCAN Betul , ÜNAL Ali 
Published: September 2023

Introduction: Drug drug interactions can effect the success of stem cell transplantation process. Therefore, analyzing the risk of these interactions would be helpful for practitioners. This study was conducted to identify drug-drug interactions in allogeneic and autologous stem cell transplantation patients before and after transplantation.
Methods: Patients who underwent allogeneic stem cell transplantation and autologous stem cell transplantation were included in the study. Patients’ treatment sheets were collected ten days before transplantation day, on the transplantation day, and ten days after transplantation day. Drug-drug interactions were analyzed by using four drug-drug interaction checking databases.
Results: 50 patients from both transplantation types were included. The mean ages for allogeneic and autologous transplants were 42.4 and 51.8, respectively. 52% of allogeneic transplants and 28% of autologous transplants were on ≥5 drugs at tenth day before transplantation. The means of interactions in allogeneic and autologous stem cell transplantation patients were 75.42 and 43.62, respectively. The detection of at least one contraindicated interaction in allogeneic and autologous transplant patients were 94% and 92%, respectively. In 48% of allogeneic transplants and 36% of autologous transplants, two or more contraindicated interactions were detected.
Conclusion: Allogeneic stem cell transplantation patients experienced almost two times more drug-drug interactions than autologous stem cell transplantation patients. Transplantation type, being in the pre and post-transplantation period and the drug number at the beginning of the transplantation process matter in terms of the number of drug-drug interactions. Identifying interactions in terms of transplantation type and existing medications is very important.
Algoritmos para calcular el grado de los vértices de la gráfica de divisores de cero de anillos Z_n
Authors: Morales Raúl Juárez , Morales José Ángel Juárez , González Luis Alberto Lucrecio , Casarrubias Concepción Rojas , Martínez Manuel Trejo 
Published: September 2023

Sea a gráfica finita, simple y conexa, con conjunto de vértices y conjunto de arista . Sea un anillo conmutativo finito con identidad. La gráfica de divisores de cero de es una gráfica en la cual los vértices son los divisores de cero diferentes de cero de este anillo, dos vértices distintos son adyacentes si su producto es cero. Esta gráfica es denotada por . En este artículo se diseñaron algoritmos para obtener el grado de los vértices de la gráfica de divisores de cero de anillos para algunos casos de donde y son primos distintos y , son enteros positivos mayores o iguales a 2. También se obtienen particiones del conjunto , a estos subconjuntos de vértices se les calcula su respectivo cardinal.
EDUCAÇÃO A DISTÂNCIA: CURSO DE FORMAÇÃO DE TUTORES E SUPERVISORES PARA CURSOS TÉCNICOS DE SAÚDE NO BRASIL
Authors: Mariangela Kraemer Lenz Ziede  , Luciane Magalhães Corte Real  , Denise Barbosa de Castro Friedrich  , Cassiane Silocchi  , Fabiana Schneider Pires  
Published: September 2023

A Educação a distância é uma modalidade de ensino e aprendizagem que possibilita a formação de estudantes em espaços e tempos distintos. Introdução: Nessa perspectiva é apresentado o curso de formação de supervisores e tutores, realizado na modalidade a distância no ambiente virtual de aprendizagem Moodle, da Universidade Federal do Rio Grande do Sul, do Brasil. O curso é composto por 10 módulos e cada módulo tem a duração de 30 dias. Os participantes da pesquisa realizam a parte teórica no Moodle e a parte prática num curso voltado a trabalhadores da saúde que ocorre em todo o território nacional. Objetivo: Analisar a percepção dos cursistas sobre as suas aprendizagens no curso de formação de supervisores e tutores na modalidade a distância. Método: É um estudo descritivo com abordagem qualitativa de análise temática. A coleta de dados foi realizada a partir do questionário COLLES (Constructivist Online Learning Environment Survey) online aplicado no quinto módulo, para orientar possíveis reconstruções das atividades até o final do curso. Foi utilizada a questão aberta para a análise deste artigo. Resultados: Obtivemos 4190 respostas no total de 4400 cursistas, destas 639 participantes responderam também a uma questão aberta que solicitava comentários a respeito do curso de formação. Na análise temática textual foram elencadas duas categorias: aprendizagem e educação permanente em saúde. Conclusão: O curso de formação possibilitou diversas aprendizagens dentre elas aprimorou a qualidade dos processos de mediação e feedbacks nos fóruns e nas atividades propostas. A aprendizagem na modalidade a distância apresenta-se muitas vezes como um desafio, porém gradualmente os tutores e supervisores avançaram na superação destes, seja pelo apoio das equipes do Curso, por um maior conhecimento da realidade que estão inseridos e das necessidades dos estudantes, pela análise dos resultados das propostas em ação ou mesmo por essa conjunção de fatores.
Therapy with direct antiviral drugs in patients with HCVassociated cryoglobulinemic vasculitis – is it always possible to achieve complete clinical and immunological responses after the virus eradication?
Authors: Milovanova S. Yu. , Kozlovskaya (Lysenko) L. V. , Milovanova L. Yu. , Abdurakhmanov D. T. , Taranova M. V. , Volkov A. V. 
Published: September 2023

Background. The use of direct acting antiviral drugs (DAАs) leads to the achievement of a stable virological response (SVR) in 95–100 % of patients with HCV-associated cryoglobulinemic vasculitis (HCV-CV). However, in some patients, despite the eradication of the virus, clinical and immunological markers of vasculitis still remain.The aim: to evaluate clinical and immunological responses in patients with HCV-CV in comparison with patients with "asymptomatic" HCV- associated cryoglobulinemia (HCV- СG) after achieving SVR with the help of DAАs with long-term dynamic observation (12 months).Patients and Methods: The study included 45 patients: 23 with HCV-CV and 22 with "asymptomatic" HCV-CG, who underwent antiviral therapy with DAAs. Clinical-immunological, virological data were evaluated: before treatment, 12 weeks (3 months) and 48 weeks (12 months) after the end of treatment.Results: After a course of DAAs, SVR was diagnosed in all 45 (100 % of patients). In patients with HCV-CV, an immunological response (complete and partial) was observed by week 12 (SVR12) – in 56.5 % and by week 48 (SVR48) – in 73.9 % patients. In 6 patients (26.1 %), the immunological response was not achieved by SVR48. The rate of complete and partial clinical response 12 weeks after the end of treatment at the SVR12 period in patients with HCV-CV was 65.2 %, to the time of SVR48 amounted to 78.3 % patients. In 5 (21.7 %) individual manifestations of CV persisted and/or relapsed. In patients with HCV-CG, the frequency of complete and partial immunological responses after DAAs therapy was 77.3 % – by SVR12 and 86.3 % – by SVR48, respectively. No response was observed in 3 patients and it was characterized by trace-level of cryoglobulinemia.Conclusion: In most patients with HCV-CV eradication of HCV with help of DAAs leads to the achievement of clinical and immunological remission of the disease. However, in 20 % of patients manifestations of HCV-CV persist / recur immediately after the end of treatment or later relapses are observed. Based on these observations, patients with HCV-CV, especially those with severe underlying skin and kidney disease, are required long-term monitoring after SVR is achieved.
Epidemias e pandemias no mundo e em Portugal. Das preocupações com a vida e saúde às políticas públicas de saúde.
Authors: D´ Arrábida Cristina Martins 
Published: September 2023

O presente artigo apresenta a análise das epidemias e pandemias que assolaram o mundo e Portugal, ao longo da história da humanidade, com impactos religiosos, sociais, económicos e políticos, afetando a própria evolução das sociedades. Realçam-se as preocupações com a preservação da vida, medidas sanitárias e mais tarde medidas de políticas públicas de saúde. O procedimento metodológico utilizado é a análise documental nas suas diferentes fases e análise comparativa. O conhecimento e as lições aprendidas podem contribuir para as políticas de saúde pública, a par da promoção da saúde e prevenção da doença, acautelarem respostas a emergências de saúde pública, através de sistemas de saúde robustos e de cobertura universal, a base do investimento para proteção dos cidadãos e da própria economia dos países.
Acrylamide Intake in Nairobi Kenya
Authors: Abong George  , Okoth Michael Wandayi  , Joy Wambui Miriti  , Jackson Ntongai Kabira  
Published: September 2023

Among the safety concerns in fried potato products are the levels of acrylamide. High intake of acrylamide has been linked to carcinogenicity in animals and it remains a suspect human carcinogen. The current study was intended to assess exposure to acrylamide through consumption of French fries in Nairobi, Kenya. Data on levels of acrylamide was obtained by analysing samples purchased from fast food outlets in Nairobi while consumption survey was carried out in the same region targeting individual consumers. Consumption data was combined with levels and dietary acrylamide exposure was calculated using probabilistic approach. Results indicated that 57.8% of respondents were males while 42.2% were females. Majority (64.1%) of the consumers were in the age bracket of 20- 29 years. About 17.8% of the respondents consumed French fries once daily, while 78.7% consumed fries at least once a week. Average acrylamide levels in French fries significantly (p<0.05) differed with point of purchase being highest in middle end hotel fries (412 µg/kg) followed by fries from street processors (354.18 µg/kg) and high-end hotels (136.15 µg/kg). The mean and 95th (P95) percentile acrylamide intakes for consuming street processed fries were respectively 0.693 and 2.469 µg/kg bw/day, while for the middle end hotels were 0.81 and 3.369 µg/kg bw/day, respectively. The mean and 95th (P95) percentile acrylamide intakes for consumption of high-end hotel fries were 0.256 and 1.035 µg/kg bw/day, respectively. When the worst-case scenario was considered, the mean margins of exposure for the street fries (260) and middle hotel fries (223) were below 310 with 95th percentiles being extremely low at 73 and 53, respectively. Consumers of these fries are at high risk of exposure. High exposures in the current study should warrant concern and need for appropriate measures to be taken by appropriate agencies.
Assessing community perceptions and response to climate change in nyando catchment using geospatial technology
Authors: Betty Mulianga  , Ivy Ng'onyere  
Published: September 2023

The world is experiencing climate crisis that is threatening lives. Those in low lands are displaced by floods loosing possessions and food crops; while those in hilly areas experience land degradation and vegetation loss leading to poverty. Monitoring such occurrence through time is inevitable as it enables governments to make critical decisions for environmental conservation, enhanced resilience and minimize risks of food insecurity. This study explored the use of geospatial technology to investigate climate risk indicators within Nyando catchment. Geospatial technology provides a platform to monitor occurrences of extreme weather conditions, facilitates the understanding of end to end temporal changes of the environment and provides an environment for modelling future scenarios. We derived indicators of climate change within Nyando catchment over the period 2013 to 2021 and inferred their impact on livelihoods. We collected data on rainfall, vegetation cover and land use from Landsat 8 30m satellite images and in situ data using the Mobile mapper global positioning system (GPS) within Nyando catchment. We overlaid these data, characterized them and performed change detection using Erdas Imagine software. Results showed 9.9% reduction in forest cover, 54.1% sedimentation of water areas, 3.9% loss of agricultural land and 2.5% increase in built up areas. The main land use in Nyando catchment is agriculture followed with settlement. We inferred that loss of forest cover is the reason for sedimentation of the water areas, subjecting lowlands to flooding. Moreover, conversion of forest land to agricultural land and settlement were fund to be the main drivers for climate crisis. Indeed agro-ecological approaches to farming will increase forest area while maximizing on vertical farming for increased productivity to meet the ever growing demand for food. We recommend adoption of geospatial technology in monitoring of the landscape for informed decision making to avert risks of climate change.
Physiochemical and sensory characteristics of a supplementary food for malnourished underfive children, a case of maize, millet and peanut
Authors: Mwangi John , Abong' George , Okoth Michael 
Published: September 2023

Malnutrition in children remains a major public health challenge in developing countries. The local un-availability of the necessary ingredients and lack of knowledge on how to prepare food for malnourished children are among the primary causes of child malnutrition. The study sought to determine the use of locally available food material (maize, millet and peanut) in formulating a food product to address the rampant protein- energy malnutrition of children in Kenya. The linear programming model of the nutrisurvey computer software was used in generating six treatments of a supplementary food as follows: Sample A=27%millet, 36%maize, 28% peanut and 9% oil, B=30%millet, 33%maize, 30% peanut and 7% oil, C=32%millet, 19%maize, 38% peanut and 11% oil, D=35%millet, 11%maize, 42% peanut and 12% oil, E= 35%millet, 30%maize, 26% peanut and 9% oil and F=40%millet, 20%maize, 30% peanut and 10% oil . Physico-chemical and sensory attributes of the supplementary food were determined using standard procedures. The moisture, energy, protein, fat, carbohydrate, dietary fiber, total ash, iron, calcium and zinc of 100 g of the products A,B,C,D,E and F were found to have ranges from: 3.9 ±0.3g to 5.2 ±0.3g, 424.0kcal 485.0kcal, 9 ±1.1 to 14.1 ±1.1g, 23.9 ±0.2 to 35.9 ±0.1g, 28.7 ±0.7 to 52.4 ±1.4g, 7.9 ±1.8 to 18.0 ±1.0g, 1.6 ±0.01 to 2.1 ±0.02g, 2.0 ±0.7 to 7.0 ±0.1g, 14.47 ±0.3 to 33.4 ±0.3g, 2.6.0 ±0.0 to 4.4 ±0.1g respectively. The formulations chemical attributes were in the range that meets the RDA’s requirements for children under five in 2 to 3 serving of 100g of the products and thus, it’s supplementation to other foods given to the child could be effective in the treatment of malnourished children after the clinical trial.
Digital environment in teaching Russian as a foreign language: views of the publisher, developer, teacher
Authors: Голубева А.В. , Голубев Н.С. , Алешина А.Б. , Бекезина Т.А. 
Published: September 2023

На примере онлайн-ресурсов Центра «Златоуст» описываются подходы к разработке обучающих цифровых ресурсов со стороны издателя, разработчика и преподавателей. Представлены основные вопросы, встающие при создании подобных ресурсов, и возможные варианты решений. Авторы приходят к выводу, что для реальных образовательных инноваций в преподавании РКИ, для внедрения приемов и технологий, которые вовлекают учащихся в углубленную обработку экранного текста, русистам следует шире обращаться к опыту современного корпоративного онлайн-обучения. В этой сфере реальные результаты использования технологий отслеживаются более тщательно. Без серьезной исследовательской работы, без надежной научной аналитики говорить о реальных инновациях в данной предметной области явно преждевременно, только новых технологий и энтузиазма для по-настоящему новых методик недостаточно.
Using the example of the online resources of the Zlatoust Center, approaches to the development of educational digital resources from the publisher, developer and teachers are described. The main issues that arise when creating such resources and possible solutions are presented. The authors conclude that for real educational innovations in teaching Russian as a foreign language, for the introduction of techniques and technologies that involve students in in-depth processing of screen text, Russian specialists should turn more widely to the experience of modern corporate online learning. In this area, the actual results of the use of technology are monitored more carefully. Without serious research work, hopeless scientific analytics, it is clearly premature to talk about real innovations in this subject area, only new technologies and enthusiasm for truly new techniques are not enough.
THE LEARNING ENVIRONMENT OF A SYNCHRONOUS ONLINE LESSON IN TEACHING SECOND LANGUAGE (ON THE EXAMPLE OF RSL): COMPONENTS AND FEATURES
Authors: Родионова К.Е. 
Published: September 2023

В статье рассматривается образовательная среда синхронного онлайн-урока, ее компоненты и особенности. Осмысливается понятие образовательной среды с точки зрения андрагогики (т. е. обучения взрослых). Анализируются различные авторские трактовки данного понятия в научном поле в рамках как очного, так и дистанционного обучения. Дается анализ понятия образовательной среды синхронного онлайн-урока и описывается ее компонентный состав.
This article discusses the concept of learning environment in the framework of synchronous RSL online learning, its components and features. The concept of the learning environment is comprehended from the point of view of andragogy (i. e. adult education). Various author's interpretations of this concept in the scientific field in full-time and distance learning are described. The analysis of the concept of the learning environment of a synchronous online lesson is introduced and its component composition is proposed.
Ethno-oriented approach in RCT training: the search for an answer to the challenges of the time
Authors: Кольовска Е.Г. , Степаненко В.А. 
Published: September 2023

В статье рассматривается этноориентированная модель обучения, получившая распространение в преподавании РКИ во второй половине ХХ в. Авторы отмечают, что этноориентированная направленность в учебниках того времени выражалась прежде всего в переводе лексики и в грамматических комментариях на родном языке учащихся. Сегодня наблюдается новый виток в развитии этноориентированного обучения: оно включает в себя культурологическую составляющую. Ее соединение с цифровыми технологиями открывает новые возможности в применении этноориентированного подхода к обучению инофонов.
The article deals with an ethno-oriented model of education, which became widespread in the teaching of Russian as a foreign language in the second half of the 20th century. The authors note that the ethno-oriented aiming in the textbooks of that time was expressed first of all in the translation of vocabulary and in grammatical comments in the native language of students. Today there is a new stage in the development of ethno-oriented education: it includes a cultural component. Its connection with digital technologies opens up new possibilities in applying an ethno-oriented approach to teaching foreigners.
Pengaruh Automatic Teller Machine Dan Mobile Banking Terhadap Kepuasan Nasabah
Authors: Agustin Audilia , Rosa Edy Safni , Mulyana Ade 
Published: September 2023

This research is motivated by the rapid internet users. This is due to the increasing needs of the community. One of the people's needs for internet users is the need for bank facilities that can facilitate people in transacting. With good quality bank facilities can affect customer satisfaction.
The purpose of this study was to determine (1) the effect of the Automatic Teller Machine (ATM) on customer satisfaction at Bank BRI Baranangsiang Branch, Bogor City. (2) The influence of Mobile Banking on customer satisfaction at Bank BRI Baranangsiang Branch, Bogor City. (3) The effect of Automatic Teller Machine (ATM) and Mobile Banking services on customer satisfaction at Bank BRI Baranangsiang Branch, Bogor City. The purpose of this research is to examine the significant effect of Automatic Teller Machine and Mobile Banking on Customer Satisfaction at Bank BRI Baranangsiang Branch, Bogor City, partially (individually) or simultaneously (together).
The result of this study shows that partially Mobile Banking had positive and significant effect on customer statisfaction. Automatic Teller Machine (ATM) have a positive and significant effect on customer statisfaction. And simultaneously Mobile Banking and Automatic Teller Machine (ATM) have a positive and significant effect on customer statisfaction.The number of respondents in this study amounted to 100 respondents. The data in this study were collected using IBM SPSS Statistics 25. This study used a quantitative approach. Sampling by simple random sampling method. The data used are primary data obtained from the results of filling out the questionnaire. The data collection technique used is a questionnaire. In this study using multiple linear regression analysis method by fulfilling the classical assumption test. The results showed

Keyword : Automatic Teller Machine, Mobile Banking and Costumer Satisfaction
Pengaruh Pandemi Covid-19 Terhadap Minat Penggunaan Layanan Mobile Banking
Authors: Sudjali Iwan Purwanto , Akbar Muhammad Alwi , Rosa Edy Safni 
Published: September 2023

Currently, Indonesia is experiencing a national disaster in the form of the Covid-19 which is a virus with a very fast transmission rate.pandemic Covid-19 is allegedly not only attacking health but also affecting the global economy. In the end, many people use digital transactions such as Mobile banking during this pandemic. Mobile Bankingaservice provided by banks to facilitate their customers in transacting anywhere and anytime. Mobile banking useful for customers in carrying out government policies of stay at home and physical distancing to break the chain of virus spread during the covid 19
This study aims to determine the effect of Stay at home (X1) and Physical distancing (X2) on interest in using Mobile banking (Y) during the Covid-19. The method used in this study is multiple linear regression analysis, this is an analysis that describes the form of influence between one or more variables with other variables. The type of data used in this study is a secondary data source that was processed from 100 respondents from customers of Bank Central Asia Tbk Bogor Main Branch Office.
Based on the results of data processing, there is a significant positive effect between stay at home on interest in using Mobile banking services at PT Bank Central Asia Tbk Bogor Main Office, there is a significant positive effect between physical distancing on interest in using Mobile banking services at PT Bank Central Asia Tbk Bogor main office. There is a joint influence of stay at home and physical distancing on the Interest in Using Mobile banking Services PT Bank Central Asia Tbk Bogor Main Office.
Keywords: Stay at home, physical distancing, intention, and Mobile Banking