bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cognitive Impairment After Ischemic and Hemorrhagic Stroke: A Scientific Statement From the American Heart Association/American Stroke Association
Authors: El Husseini Nada , Katzan Irene L. , Rost Natalia S. , Blake Margaret Lehman , Byun Eeeseung , Pendlebury Sarah T. , Aparicio Hugo J. , Marquine María J. , Gottesman Rebecca F. , Smith Eric E. ,   on behalf of the American Heart Association Stroke Council; Council on Cardiovascular and Stroke Nursing; Council on Cardiovascular Radiology and Intervention; Council on Hypertension; and Council on Lifestyle and Cardiometabolic Health
Published: May 2023

Purpose:
Cognitive impairment is a common consequence of stroke and has direct implications for poststroke functioning and quality of life, including the ability to maintain a job, live independently, sustain interpersonal relationships, and drive a vehicle. In this scientific statement, we critically appraise the literature on the prevalence, diagnosis, and management of poststroke cognitive impairment (PSCI) and provide a framework for clinical care while highlighting gaps that merit further study.

Methods:
We performed a scoping literature review of randomized controlled clinical trials, prospective and retrospective cohort studies, case-control studies, clinical guidelines, review articles, and editorials on the incidence and prevalence, natural history, diagnosis, and management of PSCI. Scoping reviews determine the scope of a body of literature on a given topic to indicate the volume of literature and the studies currently available and provide an overview of its focus.

Results:
PSCI is common after stroke, especially in the first year, and ranges from mild to severe. Although cognitive impairment is reversible in some cases early after stroke, up to one-third of individuals with stroke develop dementia within 5 years. The pathophysiology is not yet fully elucidated but is likely attributable to an acute stroke precipitating a series of pathological events, often in the setting of preexisting microvascular and neurodegenerative changes. Screening for associated comorbidities and interdisciplinary management are integral components of the care of individuals with PSCI. There is a need for prospective studies evaluating the individual trajectory of PSCI and the role of the acute vascular event in the predisposition for Alzheimer disease and related dementias, as well as high-quality, randomized clinical trials focused on PSCI management.
Grammatical Error Correction: A Survey of the State of the Art
Authors: Bryant Christopher , Yuan Zheng , Qorib Muhammad Reza , Cao Hannan , Ng Hwee Tou , Briscoe Ted 
Published: May 2023

Abstract
Grammatical Error Correction (GEC) is the task of automatically detecting and correcting errors in text. The task not only includes the correction of grammatical errors, such as missing prepositions and mismatched subject–verb agreement, but also orthographic and semantic errors, such as misspellings and word choice errors, respectively. The field has seen significant progress in the last decade, motivated in part by a series of five shared tasks, which drove the development of rule-based methods, statistical classifiers, statistical machine translation, and finally neural machine translation systems, which represent the current dominant state of the art. In this survey paper, we condense the field into a single article and first outline some of the linguistic challenges of the task, introduce the most popular datasets that are available to researchers (for both English and other languages), and summarize the various methods and techniques that have been developed with a particular focus on artificial error generation. We next describe the many different approaches to evaluation as well as concerns surrounding metric reliability, especially in relation to subjective human judgments, before concluding with an overview of recent progress and suggestions for future work and remaining challenges.We hope that this survey will serve as a comprehensive resource for researchers who are new to the field or who want to be kept apprised of recent developments.
Comparing Selective Masking Methods for Depression Detection in Social Media
Authors: Pananookooln Chanapa , Akaranee Jakrapop , Silpasuwanchai Chaklam 
Published: May 2023

Abstract
Identifying those at risk for depression is a crucial issue and social media provides an excellent platform for examining the linguistic patterns of depressed individuals. A significant challenge in depression classification problems is ensuring that prediction models are not overly dependent on topic keywords (i.e., depression keywords) such that it fails to predict when such keywords are unavailable. One promising approach is masking—that is, by selectively masking various words and asking the model to predict the masked words, the model is forced to learn the inherent language patterns of depression. This study evaluates seven masking techniques. Moreover, predicting the masked words during the pre-training or fine-tuning phase was also examined. Last, six class imbalanced ratios were compared to determine the robustness of masked words selection methods. Key findings demonstrate that selective masking outperforms random masking in terms of F1-score. The most accurate and robust models are identified. Our research also indicates that reconstructing the masked words during the pre-training phase is more advantageous than during the fine-tuning phase. Further discussion and implications are discussed. This is the first study to comprehensively compare masked words selection methods, which has broad implications for the field of depression classification and general NLP. Our code can be found at: https://github.com/chanapapan/Depression-Detection.
The Application of Immersive Virtual Reality and Machine Learning for the Assessment of Unilateral Spatial Neglect
Authors: Belger Julia , Poppe Stephan , Karnath Hans-Otto , Villringer Arno , Thöne-Otto Angelika 
Published: May 2023

Abstract
Even subtle forms of hemispatial neglect after stroke negatively affect the performance of daily life tasks, increase the risk of injury, and are associated with poor rehabilitation outcomes. Conventional paper-and-pencil tests, however, often underestimate the symptoms. We aimed to identify relevant neglect-specific measures and clinical decision rules based on machine learning techniques on behavioral data generated in a new Virtual Reality (VR) application, the immersive virtual road-crossing task. In total, 59 participants were included in our study: two right-hemispheric stroke groups with left neglect (N = 20) or no neglect (N = 19), classified based on conventional tests and medical diagnosis, and healthy controls (N = 20). A neuropsychological test battery and the VR task were administered to all participants. We applied decision trees and random forest models to predict the respective groups based on the results of the VR task. Our feature selection procedure yielded six features as suitable predictors, most of which involved lateral time-related measures, particularly reaction times, and head movements. Our model achieved a high training accuracy of 96.6% and estimated test accuracy of 76.8%. These results confirm previous reports that temporal behavioral patterns are key to detecting subtle neglect in patients with chronic stroke. Our results indicate that VR combined with machine learning has the potential to achieve higher test accuracies while being highly applicable to clinical practice.
Polka-dotted treasures: Revising a clade of ascidian- and bivalve-associated shrimps (Caridea: Palaemonidae)
Authors: de Gier Werner , Fransen Charles H.J.M. 
Published: May 2023

Abstract
Most marine shrimp species of the family Palaemonidae are characterized by symbiotic associations with hosts that belong to a wide range of invertebrate phyla. One clade of related endosymbiotic species has evolved to live inside the branchial chambers of ascidians and the mantle cavities of bivalve molluscs. The phylogeny of this clade (comprising 15 bivalve-associated species in the genera Anchistus, Neoanchistus, and Paranchistus, and three species of ascidian-associated species in the genus Dasella) is the topic of the present study, which is based on both morphological and molecular data. A concatenated phylogeny reconstruction was built by using the markers coi and 16S. With the help of a total evidence approach (with a scored morphological datamatrix), species could be added for which no molecular data were available. An ancestral character state analysis was performed to detect host switches. In contrast to another endosymbiotic clade, the ancestral host state was found to be slightly in favour of bivalves. The phylogenetic relevance of morphological features is discussed with a focus on a tympanal organ located in the major chelipeds of some bivalve-associated shrimp species. This little-known anatomical structure is illustrated by sem and µCT scans. Its possible function is discussed. In the phylogeny reconstructions, both Anchistus and Paranchistus were found to be polyphyletic. They were reclassified to obtain a more natural classification: Anchistus custoides and Anchistus custos were transferred to the resurrected genus Ensiger. Paranchistus liui, P. nobilii, P. pycnodontae, and P. spondylis were transferred to Polkamenes gen. nov. Anchistus pectinis and P. ornatus were transferred to Tympanicheles gen. nov. Per genus, a key to the species is provided.
Depreciation of Military Service Costs in the Fifteenth and Sixteenth Centuries in Central-Eastern Europe
Authors: Lopatecki Karol , Boldyrew Aleksander 
Published: May 2023

The article presents the depreciation of soldiers’ equipment in the fifteenth–sixteenth centuries in Central-Eastern Europe based on the data from a dedicated financial institution existing in the Polish Kingdom until the 1560s. Soldiers received their pay, and the king additionally paid them compensation for any war damage. Owing to meticulous records, data were collected on 9,371 individuals. Based on the collected data, it has been established that the average losses in cavalry were equivalent to 40% of the pay and in infantry, the corresponding ratio was 13.7%. This formation was not only cheaper to equip, it was also less cost-intensive. The article elaborates on the background of the liquidation of this institution in the Polish Crown, combined with an increase in soldiers’ pay, who gained only seemingly. It was mainly a profitable operation for the state. It improved the budgeting process, increased the combat value of the soldiers, facilitated military bureaucratisation and prevented extorted compensation. After the reform, the depreciation in the cost of the soldier’s pay is estimated to have been about 1/3. The percentage chance of losing a horse, arms and armour was also calculated, demonstrating a huge equine mortality rate of 48.2% over three months of fighting.
Do Values Predict Socially Responsible Investment Decisions? Measuring the Moderating Effects of Gender
Authors: Raut Rajdeep Kumar , Kumar Rohit 
Published: May 2023

This study examines investors’ pro-environmental investment intentions by measuring the effect of economic concern (egoistic value) and environmental concern (altruistic value) on attitudes toward socially responsible investment (SRI). A self-administered structured questionnaire was used to collect data from 469 investors using a purposive sampling technique and analyzed using two-step structural equation modeling. Results show that both altruistic and egoistic values were significant predictors of a positive attitude toward SRI, portraying the greater environmental concern of investors. Additionally, male investors motivated to invest in SRI are more concerned about environmental well-being than their counterparts, that is, female investors. By analyzing values as antecedents of attitudes toward SRI, the findings of this study add a new dimension to the belief system of young investors. JEL Codes: A13; D19; G1; G4
Small open reading frames: a comparative genetics approach to validation
Authors: Jain Niyati , Richter Felix , Adzhubei Ivan , Sharp Andrew J. , Gelb Bruce D. 
Published: May 2023

AbstractOpen reading frames (ORFs) with fewer than 100 codons are generally not annotated in genomes, although bona fide genes of that size are known. Newer biochemical studies have suggested that thousands of small protein-coding ORFs (smORFs) may exist in the human genome, but the true number and the biological significance of the micropeptides they encode remain uncertain. Here, we used a comparative genomics approach to identify high-confidence smORFs that are likely protein-coding. We identified 3,326 high-confidence smORFs using constraint within human populations and evolutionary conservation as additional lines of evidence. Next, we validated that, as a group, our high-confidence smORFs are conserved at the amino-acid level rather than merely residing in highly conserved non-coding regions. Finally, we found that high-confidence smORFs are enriched among disease-associated variants from GWAS. Overall, our results highlight that smORF-encoded peptides likely have important functional roles in human disease.
Incidence of thromboembolism in children with primary nephrotic syndrome: a systematic review and metaanalysis
Authors: Wang Zhen , Tang Han-Yun , Lin Qiang , Li Xiao-Zhong 
Published: May 2023

AbstractObjectiveTo estimate the incidence of thromboembolism in children with primary nephrotic syndrome with Meta-analysis.MethodsRelevant studies published from January 1, 1980 to December 31, 2021 were retrieved from Pubmed, Web of science, Cochrane library, China National Knowledge Infrastructure (CNKI), China Science and Technology Journal Database(VIP) and Wangfang Database. Quality evaluation of the literatures included was conducted according to Agency for Healthcare Research and Quality(AHRQ) assessment tool, followed by data extraction and Meta-analysis with software RevMan 5.3.ResultsA total of seven studies involving 3675 subjects were included. The overall prevalence was 4.9% with 95% CI of 2.83 to 7.05.However, a significant heterogeneity (P < 0.001) was observed withI2 = 89%. The prevalence of venous thromboembolism was 3.3% with 95% CI of 1.7 to 4.9. The prevalence of arterial thromboembolism was 0.5% with 95% CI of 0.2 to 1.4.ConclusionChildren with nephrotic syndrome are prone to thromboembolism, and it may lead to disability or death, therefore prevention measures is critical to decreasing the prevalence of thromboembolism.
Pattern, frequency and factors associated with inappropriate high dosing in chronic kidney disease patients at a tertiary care hospital in Pakistan
Authors: Hayat Muhammad , Ahmad Nafees , Khan Syed Liaquat Ali , Mohkumuddin Syed , Siddique Wajeeha , Khan Amjad , Atif Muhammad 
Published: May 2023

Abstract
Background
Patients with chronic kidney diseases (CKD) are susceptible to the toxic drug effects if given unadjusted doses. Although Pakistan harbors a high burden of CKD patients, there is limited information available on the frequency, pattern and factors associated with unadjusted drug doses among CKD patients.

Methods
This cross-sectional study conducted at Sandeman Provincial Hospital, Quetta included 303 non-dialysis ambulatory CKD patients (glomerular filtration rate < 60 ml/min/1.73m2). The patients’ data were collected through a purpose designed data collection form. The appropriateness of doses was checked against the renal drug handbook-2018, Kidney Disease Improving Global Outcomes guidelines, British National Formulary-2022, and manufacturer leaflets. Data were analysed by SPSS 23 and multiple binary logistic regression analysis was used to assess the factors associated with receiving inappropriate high doses. A p-value < 0.05 was considered statistically significant.

Results
The patients received a total of 2265 prescription lines, with a median of eight different drugs per patient (interquartile range: 6–9 drugs). A total of 34.5% (783/2265) drugs required dose adjustment. Of these, doses were not adjusted for 56.1% (440) drugs in 162 (53.4%) patients. The most common pharmacological class of drugs requiring dose adjustment were antibiotics (79.1%), followed by antidiabetics (59.2%), diuretics (57.0%), angiotensin converting enzyme inhibitors (56.9%), beta blockers (56.9%), analgesics (56.0%), angiotensin receptor blockers (55.2%), domperidone (53.9%) and antihyperlipidmics (46.1%). Patient’s age of 41–60 (OR = 5.76) and > 60 years (OR = 9.49), hypertension (OR = 2.68), diabetes mellitus (OR = 3.47) and cardiovascular diseases (OR = 2.82) had statistically significant association (p-value < 0.05) with inappropriate high doses.

Conclusion
The high frequency of inappropriate high doses suggests an important quality gap in medication dosing for patients with ND-CKD at the study site. Special attention should be paid to the drugs and patients with identified risk factors for receiving inappropriate high doses.
The effect of environmental factors on precocious puberty in children: a case–control study
Authors: Bigambo Francis Manyori , Wang Dandan , Niu Qing , Zhang Mingzhi , Mzava Sabitina Mrisho , Wang Yubing , Wang Xu 
Published: May 2023

Abstract
Background
Recently the prevalence of precocious puberty development is increasing among Chinese children. Proper understanding of the risk factors for precocious puberty in children is pivotal as could help to improve children's health. This study aims to evaluate the effect of environmental factors on precocious puberty in children.

Methods
We matched the cases and controls by age at the ratio of 1:1 (201 cases and 201 controls) for girls and 1:4 (24 cases and 96 controls) for boys. We used conditional logistic regression to explore the effect of environmental factors on precocious puberty, and a random forest model to identify the most important risk factor.

Results
In the multivariate regression, cesarean section (OR = 1.99, 95% CI: 1.05, 3.76), child body mass index [BMI] (OR = 1.25, 95% CI: 1.10, 1.43), maternal BMI (OR = 1.13, 95%CI: 1.01, 1.26), and exposure to secondhand smoke several times a month but less than once a week (OR = 4.09, 95%CI: 1.79,9.35), and almost every day (OR = 6.48, 95% CI: 2.14, 19.56) were risk factors for precocious puberty in girls. While maternal height (OR = 0.82, 95% CI: 0.75, 0.88), paternal height (OR = 0.91, 95% CI: 0.85, 0.98), bedtime at night (OR = 0.30, 95% CI: 0.17, 0.51), and night sleep (OR = 0.43, 95% CI: 0.21, 0.86) were protective factors. In boys, only exposure to secondhand smoke several times a month but less than once a week (OR = 7.94, 95% CI: 1.25, 50.33) was a risk factor for precocious puberty. In the random forest model, Child BMI was the most important risk factor for precocious puberty in girls.

Conclusions
Our findings suggest that environmental factors were associated with precocious puberty in children, particularly in girls.
Functionality appreciation is inversely associated with positive psychotic symptoms in overweight/obese patients with schizophrenia
Authors: Mahfoud Daniella , Fekih-Romdhane Feten , Abou Zeid Jawad , Rustom Lea , Mouez Charbel , Haddad Georges , Hallit Souheil 
Published: May 2023

Abstract
Background
While the relationship between negative aspects of body image and positive schizophrenia symptoms was extensively investigated and is relatively well-established, there is a dearth of literature on the relationship between positive symptoms and positive aspects of body image, such as body appreciation and functionality appreciation, in patients with schizophrenia. This study aimed to (1) compare weight stigma, body and functionality appreciation between obese/overweight and normal-weight patients with schizophrenia, and (2) explore the associations between these variables and positive psychotic symptoms in the obese/overweight group.

Method
A cross-sectional study was conducted in the Psychiatric Hospital of the Cross, Lebanon during September 2022 recruiting selected in-patients diagnosed with schizophrenia. Patients were classified as overweight/obese if they had a BMI > 25 (N = 76 (37.25%), aged 55.57 ± 11.30 years, 42.6% females). The Weight self‑stigma questionnaire, the Functionality Appreciation Scale, and the Body Appreciation Scale, and the Positive and Negative Syndrome Scale (PANSS) were used.

Results
No significant difference was found between overweight/obese and normal-weight patients for all variables, except for weight stigma; a significantly higher weight stigma score was significantly found in overweight/obese compared to normal-weight patient. In the bivariate analysis, higher functionality appreciation was significantly associated with higher positive PANSS scores. The results of the linear regression, taking the positive PANSS score as the dependent variable, showed that higher functionality appreciation (Beta = − 0.52) and higher social support (Beta = − 0.16) were significantly associated with lower positive PANSS scores, whereas having a secondary education level compared to illiteracy (Beta = 7.00) was significantly associated with higher positive PANSS scores.

Conclusion
Although based on cross-sectional data, these findings preliminarily suggest that higher functionality appreciation can help reduce the severity of positive psychotic symptoms in overweight/obese schizophrenia patients, and that interventions aimed at improving functionality appreciation could be regarded beneficial therapeutic targets in the treatment of psychosis.
A critical role for erythropoietin on vagus nerve Schwann cells in intestinal motility
Authors: Govindappa Prem Kumar , Begom Mosammat , Gupta Yash , Elfar John C. , Rawat Manmeet , Elfar Walaa 
Published: May 2023

Abstract
Background
Dysmotility and postoperative ileus (POI) are frequent major clinical problems post-abdominal surgery. Erythropoietin (EPO) is a multifunctional tissue-protective cytokine that promotes recovery of the intestine in various injury models. While EPO receptors (EPOR) are present in vagal Schwann cells, the role of EPOR in POI recovery is unknown because of the lack of EPOR antagonists or Schwann-cell specific EPOR knockout animals. This study was designed to explore the effect of EPO via EPOR in vagal nerve Schwann cells in a mouse model of POI.

Results
The structural features of EPOR and its activation by EPO-mediated dimerization were understood using structural analysis. Later, using the Cre-loxP system, we developed a myelin protein zero (Mpz) promoter-driven knockout mouse model of Schwann cell EPOR (MpzCre-EPORflox/flox / Mpz-EPOR-KO) confirmed using PCR and qRT-PCR techniques. We then measured the intestinal transit time (ITT) at baseline and after induction of POI with and without EPO treatment. Although we have previously shown that EPO accelerates functional recovery in POI in wild type mice, EPO treatment did not improve functional recovery of ITT in POI of Mpz-EPOR-KO mice.

Conclusions
To the best of our knowledge, this is the first pre-clinical study to demonstrate a novel mouse model of EPOR specific knock out on Schwan cells with an effect in the gut. We also showed novel beneficial effects of EPO through vagus nerve Schwann cell-EPOR in intestinal dysmotility. Our findings suggest that EPO-EPOR signaling in the vagus nerve after POI is important for the functional recovery of ITT.