bluuebunny/crossref_metadata_2025_split huggingface dataset:
Abstract 728: Socio-economic and health disparity determinants of breast cancer prevalence in low-income counties in Alabama and Mississippi: An analysis of Deep South cancer epidemic
Authors: Alagan Ram 
Published: April 2023

Abstract
Background: Studies underscore evidence that socioeconomic status (SES) is associated with breast cancer (BC)prevalence and especially poor SES is closely related to the cancer epidemic. Exploring the high and low SES status concerning BC prevalence is timely and noteworthy. Two impoverished Deep South states Alabama and Mississippi are the focus of this research. Alabama and Mississippi are well known for the historical and cultural landscape of Black Belt Counties (BBC), predominantly occupied by African American populations who were systematically undermined in many socioeconomic, healthcare, educational, and political aspects. Our investigation explores BC prevalence in the major ethnic groups (African American and White) in both southern states, mainly in the BBC.
Hypothesis/Objectives: We hypothesized that SES is closely associated with BC prevalence. In particular, the poor status of SES severely influences BC patients' access to healthcare, healthy food, obesity, education, employment, transportation, prevention, and screening. Our study explores the impact of selected SES factors to understand BC prevalence in both states, particularly in impoverished BBC.
Methods: We utilized Geospatial Technology (GT) to analyze the connection between BC prevalence and SES. This study incorporates county-level BC prevalence and association with SES, education, healthy food access, and health disparities. A robust data mining (U.S. Census, State Cancer Profile, Department of Health, American cancer society, National Cancer Institute, and published peer-reviewed journals) enabled us to explore the association between BC in the geospatial context. Integrating geospatial and non-spatial data on BC prevalence with SES will help predict and formulate BC prevention methods and promote health policy formulation and intervention in deep southern states.
Conclusions: Alabama and Mississippi are the top states concerning the BC epidemic. The research employed SESand cancer prevalence using GT. Data shows a close relation between SES and cancer prevalence. The research strongly recommends the states adopt cancer awareness programs, and social and health equity policy planning.
Citation Format: Ram Alagan. Socio-economic and health disparity determinants of breast cancer prevalence in low-income counties in Alabama and Mississippi: An analysis of Deep South cancer epidemic [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 728.
Abstract 932: Snapshot! Exploring sample diversity of sarcoma cancers across common data repositories
Authors: Gonzalez Alfredo Enrique , Patel Yash , Zhu Chenghao , Yamaguchi Takafumi N. , Tian Mao , Hiyari Sarah , Shihabi Ahmad A. , Eng Stefan , Winata Helena , Arbert Jaron , Beshlikyan Arpi , Davarifar Ardalan , Soragni Alice , Boutros Paul C. 
Published: April 2023

Abstract
Sarcoma is a cancer which originates in the body's connective tissues of mesenchymal origin. These are tissues like bones and muscles that support or protect other parts of the body. About ~16,000 sarcomas are diagnosed annually in the US, with ~6,700 deaths attributed to the disease. Sarcomas are typically divided into two major groups: bone sarcomas and soft-tissue sarcomas, each of which has multiple subtypes. However, because of their diversity in site-of-origin, sarcomas vary greatly in their presentation and histological features. Based on The World Health Organization’s (WHO) current classification system that categorizes musculoskeletal soft tissue tumours (STT) and bone tissue tumours, there are 50+ subtypes of sarcoma recognized today. Unsurprisingly, given the relative rarity of sarcoma type tumors, sample procurement has proved a challenge for the field. Consequently, there currently exist major gaps in our understanding of the genetic and molecular hallmarks of various sarcoma subtypes. Here we examine the sample and subtype classifications of sarcoma across some of the major DNA sequencing studies and data repositories to provide an overview of the available sample space. We highlight areas where the sample procurement is lagging and discuss subtypes that are missing all-together. Inclusion of some of the major genomic correlates showcases some of the similarities shared by these sequencing efforts, while emphasizing key genetic differences between subtypes. This work provides a clear roadmap for clinicians on how to best prioritize future sarcoma sample procurement and sequencing.
Citation Format: Alfredo Enrique Gonzalez, Yash Patel, Chenghao Zhu, Takafumi N. Yamaguchi, Mao Tian, Sarah Hiyari, Ahmad A. Shihabi, Stefan Eng, Helena Winata, Jaron Arbert, Arpi Beshlikyan, Ardalan Davarifar, Alice Soragni, Paul C. Boutros. Snapshot! Exploring sample diversity of sarcoma cancers across common data repositories [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 932.
Abstract PL05-03: What if all your favorite proteins are druggable
Authors: Bowman Gregory R. 
Published: April 2023

Abstract
Many proteins that play key roles in cancer are considered difficult drug targets, if not entirely undruggable, due to an apparent lack of pockets where small molecules can bind with the affinity and specificity required for a drug. ‘Cryptic’ pockets that are absent in known structures of proteins but form due to protein dynamics could alleviate this problem. However, it has been hard to assess or exploit the opportunities that cryptic pockets present due to the inherent difficulty in identifying such pockets. Here, I will discuss progress from my lab on combining biophysical experiments, computer simulations, and machine learning to identify and target cryptic pockets. In one case study, we have used computer simulations deployed on the Folding@home distributed computing environment to predict a cryptic pocket that can allosterically control a protein-RNA interaction, and then experimentally confirmed our predictions. Based on data from this study and others in our lab, we have trained a machine learning algorithm to predict where cryptic pockets are likely to form from single protein structures, enabling us to assess how prevalent cryptic pockets are on a large scale.
Citation Format: Gregory R. Bowman. What if all your favorite proteins are druggable. [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr PL05-03.
The Founding Year of the Khitan Dynasty: A Textual Investigation Based on Primary Sources
Authors: Liu Pujiang 
Published: April 2023

Abstract
This article is an investigation into the founding of the Khitan empire based on a diverse collection of historical documents from both the Northern and Central Plains regions. These sources include the official history of the Liao dynasty, Liaoshi, written during the year of dynasty’s foundation in 907, the Qidan guo zhi from 916, as well as a variety of documents ranging from as early as the late 8th century to the mid 10th century. Some historians go as far as to say that Yelü Abaoji, who ruled the Liao dynasty from 907–926, never assumed the title of emperor. Although today’s scholarship on the Liao dynasty tends to fundamentally agree that Yelü Abaoji, who is known in history books as Taizu, the first emperor of the Liao dynasty, officially proclaimed the founding of the dynasty with himself as emperor in the first year of Shence in 916, no one has yet undertaken a proper investigation as to the details of the historical source material which has led to this assumption. This article is based on primary source research and investigates these critical pieces of historical evidence surrounding the founding of the Liao dynasty to better clarify events surrounding this major historical moment.
EQA: There’s not a glitch in the matrix. Investigation of CRP bias on the Roche Cobas c701
Authors: Stevenson Emma , Walsh Chelsey , Thomas Sadie 
Published: April 2023

Background The Roche Cobas c Tina-quant C-Reactive Protein (CRP) IV method has shown persistent, significant negative bias compared to other methodologies in the UK NEQAS external quality assurance (EQA) scheme. The aim of this study was to compare CRP concentrations determined by this restandardized 4th generation assay with another commercially available method to assess the extent of any bias and impact on clinical cut-offs. Methods CRP concentrations in 38 anonymized patient serum samples were determined by a particle-enhanced immunoturbidimetric assay on the Roche Cobas c701 module and a latex assay on the Beckman Coulter AU5800 analyser over a concentration range of 1–308 mg/L. Results 97.4% samples analysed by the Roche Tina-quant CRP IV method demonstrated a negative bias compared to the Beckman AU latex method. The mean absolute bias was −4.12 mg/L (range: −19.13–10.93 mg/L; 95% CI: −17.25–9.01 mg/L). The mean relative difference was −15.5% (range: -40–4%; 95% CI: −33.03–1.94%). This bias was seen across the range of samples assayed, including at clinically significant cut-offs of 5 mg/L (−24% bias), 20 mg/L (−5%) and 100 mg/L (−13%). Conclusion The negative bias of the Roche method demonstrated in the EQA scheme appears to reflect genuine differences in patient results, rather than an EQA matrix effect, despite re-standardization of the CRP assay. This report indicates that clinical cut-offs and reference ranges may be method-dependent, which should be reflected in published guidance and interpretation provided by laboratories.
Prophylactic bilateral internal iliac balloon occlusion to control hemorrhage in placenta accreta spectrum: a boon for obstetricians
Authors: Gambhir Mohit , Gamanagatti Shivanand , Sharma Raju , Manchanda Smita , Hemachandran Naren , Dadhwal Vatsla , Sharma JB 
Published: April 2023

Background Placenta accreta spectrum (PAS) is abnormal placental adhesion beyond superficial myometrium, which may lead to severe life-threatening hemorrhage requiring massive blood transfusions in the peripartum period. Prophylactic balloon catheterization of bilateral internal iliac arteries with or without additional embolization with Cesarean hysterectomy in patients with PAS prevent excessive intraoperative hemorrhage and may also obviate the need for hysterectomy. Purpose To study the efficacy of intervention radiological procedures in controlling intraoperative hemorrhage in patients with PAS. Material and Methods This ethically approved prospective study was conducted between November 2017 and October 2019 and written informed consent was obtained from all patients. Consecutive patients diagnosed with PAS during the antepartum period were evaluated. A total of 18 patients with PAS underwent prophylactic balloon catheterization of the bilateral internal iliac arteries followed by delivery of the infant. Interventional and intraoperative data of these patients were collected and compared with retrospectively collected data of patients (control group) who underwent hysterectomy without prophylactic balloon occlusion over the past four years (January 2016–November 2019). Results Significantly lower intraoperative blood loss (2.8 L vs. 4.7 L; P = 0.048) and pure red blood cell (PRBC) requirement ( P = 0.026) between patients who had hysterectomy with and without interventional radiological management was observed. Significantly higher blood loss ( P = 0.006) and fluid requirement ( P = 0.007) was observed with a higher degree of placental invasion. Only 1 (6%) major procedure-related complication was observed. Conclusion Interventional radiological procedures are effective in significantly reducing intraoperative blood loss and blood product requirement in patients with PAS.
Nutrition of School-Aged Children and Adolescents in Europe and Central Asia Region: A Literature and Survey Review
Authors: Mates Emily , Lelijveld Natasha , Ali Zakari , Sadler Kate , Yarparvar Amirhossein , Walters Tamsin , Brown Rebecca , Rodriques Basil 
Published: April 2023

Background: Middle childhood and adolescence are critical times for the growth, development, and establishment of healthy eating habits. The Europe and Central Asia (ECA) region has been through economic and nutrition transitions over the past 20 years, which are likely to have affected the nutritional status of this group. Objective: This review aimed to collate data on the nutritional status and dietary patterns of school-aged children (SAC) and adolescents (5-19 years) across the ECA region in order to inform policy and programming decisions. Methods: A systematic search of the literature in Pubmed, Cochrane, and ScienceDirect databases was conducted (April 2019), complemented by a systematic review of nationally representative surveys. Inclusion criteria were any data on micronutrient deficiencies, overweight, stunting, wasting, thinness, or dietary patterns in SAC and adolescents in the 21 UNICEF-defined countries of ECA, published since the year 2000. Results: Results included 134 published papers and 6 sources of survey data. The majority of studies were conducted in Turkey (56%), with all other countries having fewer than 10 studies each; 8 countries in the region having no studies on this age group at all. The most significant nutrition issue was overweight and obesity. Micronutrient deficiencies, particularly anemia, emerge as a further challenge. Dietary patterns were worse in urban areas and boys. Conclusions: The findings of this review suggest that there are 3 critical areas that need immediate attention: the promotion of healthy diets and physical activity to address high levels of overweight/obesity, anemia prevention efforts, and addressing the considerable data gaps for SAC and adolescent nutrition.
A Standardized, 3-Tiered, Seizure Burden–Based Protocol for the Treatment of Neonatal Seizures
Authors: Moeller Ashley A. , Stefanescu Andrei R. , Stefanescu Beatrice M. , Golomb Meredith R. , Boyle Frances A. , Buss William F. , Rose Rebecca S. , Wing Sarah E. 
Published: April 2023

Objective To evaluate use of a standardized, 3-tiered, seizure burden-based protocol for treatment of all electroencephalography (EEG)-confirmed seizures in a level IV neonatal intensive care unit (NICU). Study Design All infants admitted to the NICU with EEG-confirmed seizures over a 25-month period were enrolled in the study. We compared short-term outcomes before and after implementation of a standardized, 3-tiered protocol. Results A total of 107 infants were enrolled in the study. Use of midazolam infusions was reduced by 53.7% ( p  = 0.02). Midazolam infusion duration increased from 4 to 7.5 days ( p = 0.003); however, when excluding 3 outliers, there was no significant difference between groups (­ p  = 0.67). Duration of EEG monitoring decreased from 5 to 3 days ( p  = 0.005). Hospital length of stay was unchanged. Conclusion Implementation of a standardized, 3-tiered protocol for treatment of neonatal seizures improved short-term outcomes. Although not measured directly, reductions in EEG duration and midazolam use are promising indicators of overall seizure burden. More research is needed to evaluate impact on long-term neurodevelopmental outcomes.
Physician leadership during the current crisis in healthcare: A perspective drawn from anthropological and clinical leadership research
Authors: Looi Jeffrey C L , Allison Stephen , Kisely Stephen R , Bastiampillai Tarun 
Published: April 2023

Objectives There are ongoing challenges in workforce sustainability and service delivery due to the COVID-19 pandemic. Recruiting credible clinical leaders can enhance outcomes through mentoring, leading by example, and creating positive work environments. We investigate the anthropology of, and related research on leadership. Conclusions Clinical and anthropological research provides strong grounds for investing in clinical leadership. The stability of ‘prestige-based’ leadership can be contrasted with the outcomes of ‘dominance-based’ leadership that relies on force, control, and threats. Dominance-based leadership increases the risks of bullying in stressed healthcare organisations. In contrast, expert clinical leaders can exert culturally mediated effects on social learning, team cooperation and morale, and patient outcomes.
Quality of Life in Breast Cancer Patients: A Systematic Review of the Qualitative Studies
Authors: Heidary Zohreh , Ghaemi Marjan , Hossein Rashidi Batool , Kohandel Gargari Omid , Montazeri Ali 
Published: April 2023

Objective Quality of life (QoL) in breast cancer patients is still an important topic. Despite numerous quantitative scales, qualitative studies can help to in-depth understand the QoL of breast cancer patients. The purpose of this systematic review was to integrate qualitative studies on the QoL of women with breast cancer. Methods A literature search was performed in electronic databases including PubMed, Scopus, and Web of Science from January 1, 2010 until June 28, 2022 to find out qualitative studies assessing breast cancer patient’s QoL. Two authors independently evaluated methodological quality according to the consolidated criteria for reporting qualitative research (COREQ) checklist. Data were extracted and reported by themes for cancer-free women and patients with metastatic cancer separately. Results In all, 1565 citations were retrieved. After removing 1387 duplicate and irrelevant papers, the full texts of 27 articles were reviewed and finally, 9 were eligible for evaluation. In quality checking of the citations, all articles gained the required quality score. After examining and merging similar topics, nine major themes were extracted. Physical, spiritual, and psychological aspects of QoL were the common issues in cancer-free women (before and after the COVID-19 pandemic) and patients with metastatic cancer. Perception of cancer and social life were the other main concerns in cancer-free women, whereas, in metastatic patients’ overall survival and planning for the future and their children’s life was the focus of interest. Women with metastatic disease showed more vulnerability in coping compared to cancer-free women. Conclusion This review provides an opportunity to have a closer look into the several domains of QoL in women with breast cancer. In-depth information provided by this review might help to develop interventions for patients and their families to support women to cope much better with their life challenges.
Anti-cancer therapeutic agents and carpal tunnel syndrome: Clinical, electrodiagnostic, and ultrasound findings in seven patients
Authors: Shields Lisa BE , Iyer Vasudeva G , Zhang Yi Ping , Shields Christopher B 
Published: April 2023

Introduction Carpal tunnel syndrome (CTS) is the most common entrapment neuropathy and rarely develops after drug therapy. This study describes the clinical, electrodiagnostic (EDX), and ultrasound (US) findings in seven patients who experienced CTS due to anti-cancer therapeutic agents. Methods All patients underwent EDX testing, and four patients had an US study. Results CTS occurred in four patients with aromatase inhibitors, two with immune checkpoint inhibitors, and one with a selective estrogen receptor modulator. The mean duration between initiation of the anti-cancer therapeutic agents and symptom onset was 6 weeks (range: 2–12 weeks). Decreased digit sensation was noted in all patients; wasting and weakness of the abductor pollicis brevis (APB) was observed in three (42.8%) patients. The compound muscle action potentials (CMAP) of the APB and sensory nerve action potentials of the second or third digit could not be recorded in two (28.5%) and four (57.1%) patients, respectively. The needle EMG detected fibrillations and positive sharp waves in the APB in two patients. The motor unit potentials of the APB were decreased with large polyphasics in three (42.8%) patients. Of the four patients who underwent US testing, all had increased cross-sectional area of the median nerve at the carpal tunnel inlet, three (75%) had thenar muscle atrophy, and two (50%) had a loss of fascicular pattern. Three (42.8%) patients underwent a CTR. Conclusions Physicians should be cognizant of the relationship between anti-cancer therapeutic agents and CTS. EDX studies and US play important roles in the diagnostic assessment of such patients.
Use of Marijuana to Promote Well-Being: Effects of Use and Prohibition in the Daily Lives of Brazilian Adults
Authors: de Lima e Silva Surjus Luciana Togni , Dainesi Natália Cavalcante , de Souza Felipe Granado 
Published: April 2023

Background: Marijuana is the most widely used illicit drug worldwide. From an occupational perspective, its use is paradoxical in that although it can be harmful to health and has criminal consequences, it can also promote well-being. This study examined predictors of well-being to determine the effects of marijuana use and its prohibition on the daily lives of Brazilian adults. Methods: This cross-sectional study used an anonymous online questionnaire with a final sample of 2637 respondents. Utilizing logistic regression, variables were selected pertaining to use and prohibition risks, benefits of use, and harm reduction associated with the socioeconomic characteristics of the respondents. Results: Using marijuana for fun was most likely among those self-identified as male, trans/non-binary people, college graduates, and those with higher incomes. Living with family members and using less frequently proved to be protective against the adverse effect of “getting high.” Indigenous peoples and youth were more likely to report trouble with the police due to marijuana use; individuals with higher education and longer use of marijuana reported more frequent use of harm reduction strategies; people who identified their color as yellow were more likely to report daily use compared to people who identified their color as white; women and people with higher income were less likely to report daily use. Conclusions: Social class, race, gender, and generation were predictors of well-being associated with marijuana use and its prohibition, indicating an interaction between different dimensions involving the use of illicit substances. Identifying the effects of the use and prohibition of marijuana in promoting well-being, from the conception of drug use as a non-sanctioned occupation, can broaden the understanding of this complex human phenomenon, with health and criminal repercussions, subsidizing the development of approaches more equitable and adequate into occupational therapy to reduce personal and social harm.