bluuebunny/crossref_metadata_2025_split huggingface dataset:
Social group membership, burnout, and subjective well‐being in new nurses in the life transition period: A cross‐sectional study
Authors: Kim Gaeyoung , Yu Hannah , Ryu Eunjung 
Published: December 2022

AbstractAimTo assess differences in social group memberships and burnout levels by work tenure among new nurses and identify factors associated with their subjective well‐being.DesignA cross‐sectional study.MethodsParticipants were 356 registered nurses who had fewer than 3 years of work tenure. Data were collected from February–March 2021. Participants' social identity, burnout, and subjective well‐being were assessed using validated questionnaires. STROBE checklist was applied.ResultsMultiple group membership was positively associated with life satisfaction and positive affect and negatively with burnout. Burnout influenced new nurses' negative effect in their life transition period. To improve new nurses' subjective well‐being, it is essential to focus on their social group membership, encourage participation in group activities, and improve access to sociopsychological resources that can help them take their first steps as professional staff and develop as healthy members of society, which will foster sustainable healthcare systems.
Dental disease reflects differential diets and changes in consumption over time at Knossos
Authors: Moles Anna C. 
Published: December 2022

AbstractKnossos was an important city on Crete and within Mediterranean networks during the Hellenistic, Roman, and Late Antique periods. However, there were significant social, cultural, and economic shifts that appear to have caused changes to daily lifeways, including diet. This paper sets out to explore dietary changes across these time periods by looking at dental caries, with reference also to antemortem tooth loss, calculus, and stable isotope data. This study also looks to contextualize these results using archaeological and textual information relating to diet. It presents a thorough methodological approach to the investigation and interpretation of caries and discusses some of the shortcomings of using a fragmentary and commingled skeletal assemblage. The Roman diet was more cariogenic than in the Hellenistic or Late Antique periods. The caries‐zone analysis of the teeth suggests that there may have been a greater addition of sugars to the diet in the Roman period, though the increased caries could also be due to improved preparation techniques and technologies producing a more refined and sticky carbohydrate diet. Such changes could be due to either increased connectivity making certain foods more readily available, the cultural changes in food consumption or dental hygiene due to the influx of merchants, colonists, migrants, and other newcomers to the Colonia Iulia Nobilis Cnosus that was Roman Knossos, or increased prosperity at the site in this period. There was a significant difference detected between females and males for caries indicating differential dietary practices between the sexes, which was most notable for the Roman period.
Transient effects of junk food on NAc core MSN excitability and glutamatergic transmission in obesity‐prone female rats
Authors: Nieto Allison M. , Catalfio Amanda M. , Papacostas Quintanilla Helena , Alonso‐Caraballo Yanaira , Ferrario Carrie R. 
Published: December 2022

AbstractObjectiveThe nucleus accumbens (NAc) plays critical roles in eating and food seeking in rodents and humans. Diets high in fats and sugars (“junk food”) produce persistent increases in NAc function in male obesity‐prone rats. This study examines effects of junk food and junk food deprivation on NAc core medium spiny neuron (MSN) excitability and glutamate transmission in females.MethodsObesity‐prone female rats were given access to ad libitum junk food for 10 days, and recordings were made from MSNs in the NAc core immediately or after a short (27‐72 hours) or long (14‐16 days) junk food deprivation period in which rats were returned to ad libitum standard chow. Controls remained on chow throughout. Whole‐cell slice electrophysiology was used to examine MSN intrinsic membrane and firing properties and glutamatergic transmission.ResultsThe study found that intrinsic excitability was reduced, whereas glutamatergic transmission was enhanced, after the short, but not long, junk food deprivation period. A brief junk food deprivation period was necessary for increases in NAc calcium‐permeable‐AMPA receptor transmission and spontaneous excitatory postsynaptic current (sEPSC) frequency, but not for increases in sEPSC amplitude.ConclusionsThis study reveals that females are protected from long‐lasting effects of sugary fatty foods on MSN neuronal function and provides evidence for sex‐specific effects on plasticity in brain centers that influence food‐seeking and feeding behavior.
Intermittent fasting and protein pacing are superior to caloric restriction for weight and visceral fat loss
Authors: Arciero Paul J. , Poe Michelle , Mohr Alex E. , Ives Stephen J. , Arciero Autumn , Sweazea Karen L. , Gumpricht Eric , Arciero Karen M. 
Published: December 2022

AbstractObjectiveThis study compared intermittent fasting and protein pacing (IF‐P) versus a heart‐healthy caloric restriction (CR) diet, matched for energy intake and physical activity energy expenditure, on body weight, total and visceral fat mass, and cardiometabolic health outcomes in adults with obesity.MethodsIF‐P (n = 21) and CR (n = 20) were assessed pre‐ (week 0), mid‐ (week 5), and post‐ (week 9) intervention.ResultsBoth groups reduced (p < 0.05) weight, total and visceral fat mass, blood pressure and lipids, and desire to eat food and increased proportion of fat‐free mass. IF‐P resulted in greater (p < 0.05) reductions in weight (−9% vs. −5%), total (−16% vs. −9%) and visceral (−33% vs. −14%) fat mass, and desire to eat (−17% vs. 1%) and increased fat‐free mass percent (6% vs. 3%) compared with CR. These improvements were despite similar weekly total energy intake (IF‐P, 9470 ± 550 vs. CR, 9095 ± 608 kcal/wk; p = 0.90) and physical activity energy expenditure (IF‐P, 300 ± 150 vs. CR, 350 ± 200 kcal/d; p = 0.79).ConclusionsIF‐P and CR optimize weight loss, body composition, cardiometabolic health, and hunger management, with IF‐P providing greater benefits.
Phytoplankton species richness as an ecological indicator in a subtropical, human‐regulated, fragmented river
Authors: Wei Jingxin , Li Weiwei , Yang Wanling , Zeng Yanyi , Liu Qianfu , Gao Yuan , Li Haiyan , Wang Chao 
Published: December 2022

AbstractSince the serial discontinuity concept (SDC) of rivers is proposed, few studies have tested it in a highly fragmented river ecosystem. In this study, environmental factors, phytoplankton species richness, and SDC predictions were demonstrated along the 13 cascade dams in a subtropical river (China). Our results indicated that among environmental factors, water temperature and transparency have seasonal differences, and river width has spatial differences; total species richness (TSR) increases from upstream to downstream, and distance is the reason for its variation. In addition, TSR also has spatial variations in each cascade dam, with the maximum or minimum value of each cascade section often occurring near the dam. A predictive model was constructed and revealed that seasonal differences in species richness were more significant than spatial differences, which were mainly observed during wet periods. Taken together, these results suggest that the construction of cascading dams enhances spatial differences in phytoplankton species richness, especially during periods of abundant water. In addition, environmental parameters such as water temperature, pH, and DO and TSR all support SDC predictions. In the future, we will continue to investigate this aquatic ecosystem to study more phytoplankton‐related indices affected by the cascade damming, and hope to fully validate the SDC predictions.
Environmental good exports and green total factor productivity: Lessons from China
Authors: Liu Huiling , Zhang Jianhua , Huang Hongyun , Wu Haitao , Hao Yu 
Published: December 2022

AbstractTrade liberalization for environmental goods (EG) could pave the way for a “win‐win” scenario for both the economy and the environment. This study examines the impact of environmental good exports on the comprehensive economic development and environmental protection index, green total factor productivity (GTFP), using a Chinese city‐level panel dataset from 2003 to 2015. Overall, our findings indicate that EG exports are detrimental to China's green development. Particularly, traditional EGs intended to address environmental concerns significantly impede GTFP, whereas environmentally preferable products with cleaner product life cycles have no such effect. Furthermore, EG exports do not significantly reduce conventional TFP without accounting for energy and pollution, implying that the loss of GTFP is primarily due to environmental factors. When GTFP is disaggregated into green efficiency change (GEC) and green technology change (GTC), EG exports can increase GEC while reducing GTC. However, once the value of EG exports surpasses a certain threshold, EG exports raise GTC and GTFP. Furthermore, regional resource misallocation, environmental regulation, and absorptive capacity can all help to mitigate the negative EG‐GTFP relationship. This study could be useful for stakeholders interested in leveraging synergies between the economy and the environment by participating in global EG supply chains.
Sustainable development of art industry and a statistical analysis of the factors that influence the gallery prices of contemporary artworks
Authors: Turan Fikret Korhan , Tosun Zeynep 
Published: December 2022

AbstractAlthough art industry has developed significantly, the factors influencing artwork prices and their specific effects are not fully known. With this research, to guide curators, gallery owners, collectors and art investors, as well as artists, first the factors that may influence artwork prices are determined. Then, using a data set from a contemporary art gallery in Istanbul, which of these factors are significant and in which ways they alter the prices are investigated. While previous studies are typically based on auction prices, promoting the economic sustainability of artists, this study employs gallery prices, and different from the existing efforts, it examines the joint impact of the artwork specific factors such as production technique and the number of editions, together with the artist specific factors including gender, education level and the field of study. Statistical findings suggest that there is no significant difference between the prices of artworks created by the artists who have a formal education in fine arts and those who do not. However, it is found that artists, particularly the female ones, can increase the prices of their artworks by having a graduate level education. Also, it is observed that increasing the number of editions negatively affects artwork prices, and the artworks created in print techniques have significantly lower prices than the artworks produced in other techniques. Though, it is detected that print artworks are less affected from the price reductions induced by the increase in the number of editions, compared to the artworks produced in other techniques.
Bioceramic materials with ion‐mediated multifunctionality for wound healing
Authors: Wang Xiaocheng , Tang Min 
Published: December 2022

AbstractRegeneration of both anatomic and functional integrity of the skin tissues after injury represents a huge challenge considering the sophisticated healing process and variability of specific wounds. In the past decades, numerous efforts have been made to construct bioceramic‐based wound dressing materials with ion‐mediated multifunctionality for facilitating the healing process. In this review, the state‐of‐the‐art progress on bioceramic materials with ion‐mediated bioactivity for wound healing is summarized. Followed by a brief discussion on the bioceramic materials with ion‐mediated biological activities, the emerging bioceramic‐based materials are highlighted for wound healing applications owing to their ion‐mediated bioactivities, including anti‐infection function, angiogenic activity, improved skin appendage regeneration, antitumor effect, and so on. Finally, concluding remarks and future perspectives of bioceramic‐based wound dressing materials for clinical practice are briefly discussed.
Co‐delivery CPT and PTX prodrug with a photo/thermo‐responsive nanoplatform for triple‐negative breast cancer therapy
Authors: Zhou Wenhui , Ma Xiaodong , Wang Jie , Xu Xiaoyu , Koivisto Oliver , Feng Jing , Viitala Tapani , Zhang Hongbo 
Published: December 2022

AbstractTriple‐negative breast cancer (TNBC) is still the most aggressive cancer in women. Combination chemotherapy holds great potential for cancer therapy; however, the off‐target and side effects of free chemotherapy administration remain a major challenge. In this study, we developed a photo/thermo‐responsive nanoplatform that can be used for TNBC treatment via photothermic therapy in combination with multidrug therapy. By conjugating the chemotherapy drug PTX prodrug on the surface of mesoporous silica‐coated gold nanorod nanoparticles and then loading another chemotherapy drug, CPT, the Au@MSN‐PTX@CPT nanoparticles exhibited great photothermal response, redox response drug release and cancer cell inhibition abilities. Otherwise, we further coated the Au@MSN‐PTX@CPT nanoparticle with a temperature‐sensitive polymer poly(N‐isopropylacrylamide‐co‐methacrylic acid) (p(NIPAM‐co‐MAAc)), and the polymer‐coated Au@MSN‐PTX@TPT@polymer nanoparticles showed perfect near‐infrared (NIR) light controlled drug release. Finally, the Au@MSN‐PTX@CPT@polymer nanoparticles were injected into the 4T1 breast cancer mouse model. The Au@MSN‐PTX@CPT@polymer nanoparticles preferably accumulated at the tumor site and had reduced chemotherapy injuries and great antitumor activity when combined with 650 nm laser treatment. In summary, our developed Au@MSN‐PTX@CPT@polymer nanoparticles served as a good method for controlled chemodrug delivery and provided a good choice for TNBC combination therapy.
Genomic prediction of tocochromanols in exotic‐derived maize
Authors: Tibbs‐Cortes Laura E. , Guo Tingting , Li Xianran , Tanaka Ryokei , Vanous Adam E. , Peters David , Gardner Candice , Magallanes‐Lundback Maria , Deason Nicholas T. , DellaPenna Dean , Gore Michael A. , Yu Jianming 
Published: December 2022

AbstractTocochromanols (vitamin E) are an essential part of the human diet. Plant products, including maize (Zea mays L.) grain, are the major dietary source of tocochromanols; therefore, breeding maize with higher vitamin content (biofortification) could improve human nutrition. Incorporating exotic germplasm in maize breeding for trait improvement including biofortification is a promising approach and an important research topic. However, information about genomic prediction of exotic‐derived lines using available training data from adapted germplasm is limited. In this study, genomic prediction was systematically investigated for nine tocochromanol traits within both an adapted (Ames Diversity Panel [AP]) and an exotic‐derived (Backcrossed Germplasm Enhancement of Maize [BGEM]) maize population. Although prediction accuracies up to 0.79 were achieved using genomic best linear unbiased prediction (gBLUP) when predicting within each population, genomic prediction of BGEM based on an AP training set resulted in low prediction accuracies. Optimal training population (OTP) design methods fast and unique representative subset selection (FURS), maximization of connectedness and diversity (MaxCD), and partitioning around medoids (PAM) were adapted for inbreds and, along with the methods mean coefficient of determination (CDmean) and mean prediction error variance (PEVmean), often improved prediction accuracies compared with random training sets of the same size. When applied to the combined population, OTP designs enabled successful prediction of the rest of the exotic‐derived population. Our findings highlight the importance of leveraging genotype data in training set design to efficiently incorporate new exotic germplasm into a plant breeding program.
Phenol removal from aqueous environments by natural & chemically modified kaolin clay
Authors: Abdel‐Aleem Adel Ahmed Mohamed , Abdel‐Tawab Marzooka Shaban , Hassouna Mohamed El‐Kassem M. 
Published: December 2022

AbstractNatural, acid and base modified kaolin clays were studied for the sake of phenol and 4‐chlorophenol removal from aqueous environments and their application to real ground and industrial wastewater samples. Scanning electron microscope (SEM), infrared spectroscopy (IR), X‐ray diffraction (XRD), Thermo Gravimetric Analysis (TGA), Differential Thermal Analysis (DTA), and Surface area analysis were employed for characterization of the adsorbents microstructure. Operating factors such as adsorbent dose, solution pH, initial phenol concentration, and contact time were studied. The experimental data displayed that the increase of the adsorbent dose, contact time, and pH value from 2 to 7 increases the efficiency of the removal process. Optimal conditions for phenolic removal were; contact time of 300 min, primary phenol solution of 25 mg/L, pH 7 and 2.5 g/L as an appropriate adsorbent dose using crude (natural), acid modified and base modified kaolin clays. The higher phenolic removal efficiencies were obtained at 5 mg/L as 90, 97, 96.2%, respectively, for the adsorbents in the previously mentioned order. The adsorption capacity in the removal of phenol and 4‐chlorophenol were 7.481 and 4.195, 8.2942 and 3.211, and 8.05185 and 18.565 mg/g, respectively, for the adsorbents in the same mentioned order. The adsorption equilibrium data were fitted and analyzed with four isotherm models, namely, Langmuir, Freundlich, Temkin, and Dubinin–Radushkevich isotherm equations. The adsorption process of phenol on studied adsorbents was exothermic, spontaneous and thermodynamically favorable proved by the negative values of their thermodynamic parameters ΔH° and ΔG°. The correlation coefficient (R2) for all concentrations was higher than 0.94, which indicates that in the studied system, the data suitably fit the first‐order kinetics. The % desorption capacity was amounted to 96%, 91.11%, and 87.06% of adsorbed phenol, respectively, for the adsorbents in the previous order using 0.1N NaOH and 10% V/V ethanol solutions as eluents at 25°C, indicating the reusability of the adsorbents. Kaolin and its modified forms can be introduced as eco‐friendly and low‐cost adsorbents in water remediation implementation.
Transmural remission improves clinical outcomes up to 5 years in Crohn's disease
Authors: Fernandes Samuel Raimundo , Serrazina Juliana , Botto Inês Ayala , Leal Tiago , Guimarães Andreia , Garcia Joana Lemos , Rosa Isadora , Prata Rita , Carvalho Diana , Neves João , Campelo Pedro , Ventura Sofia , Silva Andrea , Coelho Mariana , Sequeira Cristiana , Oliveira Ana Paula , Portela Francisco , Ministro Paula , Tavares de Sousa Helena , Ramos Jaime , Claro Isabel , Gonçalves Raquel , Correia Luís Araújo , Marinho Rui Tato , Cortez‐Pinto Helena , Magro Fernando 
Published: December 2022

AbstractIntroductionEvidence supporting transmural remission (TR) as a long‐term treatment target in Crohn's disease (CD) is still unavailable. Less stringent but more reachable targets such as isolated endoscopic (IER) or radiologic remission (IRR) may also be acceptable options in the long‐term.MethodsMulticenter retrospective study including 404 CD patients evaluated by magnetic resonance enterography and colonoscopy. Five‐year rates of hospitalization, surgery, use of steroids, and treatment escalation were compared between patients with TR, IER, IRR, and no remission (NR).Results20.8% of CD patients presented TR, 23.3% IER, 13.6% IRR and 42.3% NR. TR was associated with lower risk of hospitalization (odds‐ratio [OR] 0.244 [0.111–0.538], p < 0.001), surgery (OR 0.132 [0.030–0.585], p = 0.008), steroid use (OR 0.283 [0.159–0.505], p < 0.001), and treatment escalation (OR 0.088 [0.044–0.176], p < 0.001) compared to no NR. IRR resulted in lower risk of hospitalization (OR 0.333 [0.143–0.777], p = 0.011) and treatment escalation (OR 0.260 [0.125–0.540], p < 0.001), while IER reduced the risk of steroid use (OR 0.442 [0.262–0.745], p = 0.002) and treatment escalation (OR 0.490 [0.259–0.925], p = 0.028) compared to NR.ConclusionsTR improved clinical outcomes over 5 years of follow‐up in CD patients. Distinct but significant benefits were seen with IER and IRR. This suggests that both endoscopic and radiologic remission should be part of the treatment targets of CD.
In vitro diagnostic technologies for the detection of extracellular vesicles: current status and future directions
Authors: Song Shuya , Zhu Ling , Wang Chen , Yang Yanlian 
Published: December 2022

AbstractExtracellular vesicles (EVs) are natural vehicles carrying and transferring bioactive molecules for intercellular communication and play key roles in physiological and pathological processes. EVs are promising biomarkers for disease diagnosis due to their rich biological information and minimally invasive sampling. In this review, we summarize the current methods for isolating EVs from the body fluids and the techniques for analyzing EVs’ biomolecules including the proteins, nucleic acids, and lipids. The advantages, feasibility, and challenges of EV‐based in vitro diagnosis toward clinical application are discussed. Finally, an outlook on the marketing and routine clinical application of EV‐based in vitro diagnosis is provided.
Microfluidic devices for protein analysis using intact and top‐down mass spectrometry
Authors: Shao Xinyang , Huang Yanyi , Wang Guanbo 
Published: December 2022

AbstractTop‐down mass spectrometry (TD‐MS) provides unique information on compositions, structures, and functions of proteins or protein complexes and has been recognized as a powerful approach to complement conventional tools in protein analysis. Employing microfluidic chips in TD‐MS workflows offers unique advantages including flexible integration and automation of multiple sample treatment functions, lowered sample consumption, compatibility with high‐sensitive ionization and higher throughput. Here we reviewed the reported microchips developed for TD‐MS in aspects of design of ionization, separation and mixing modules, and fabrication approaches; we also attempted to summarize the design considerations that may inspire development of microchips with better performance and wider applications.
Anatomically resolved transcriptome and proteome landscapes reveal disease‐relevant molecular signatures and systematic changes in heart function of end‐stage dilated cardiomyopathy
Authors: Lin Ling , Liu Shanshan , Chen Zhangwei , Xia Yan , Xie Juanjuan , Fu Mingqiang , Lu Danbo , Wu Yuan , Shen Huali , Yang Pengyuan , Qian Juying 
Published: December 2022

AbstractDilated cardiomyopathy (DCM), as characterized by the left ventricular dilatation and contractile dysfunction, is one of the molecular mechanisms of which are largely unexplored. Here, we profiled the region‐resolved transcriptome and proteome of healthy and DCM human myocardial tissue and obtained the deep‐coverage dataset consisting 7,605 proteins and 19,880 transcripts in four chambers of the human heart. On the basis of the core proteome and transcriptome characters of the healthy hearts, chamber‐specific proteome alterations were further revealed in end‐stage DCM, among which extracellular matrix (ECM), mitochondrial function, and muscle contraction were the most dysregulated biological processes. Protein–protein interaction network demonstrated divergent functional networks of DCM atrium and ventricle. Additionally, a 4‐biomarker panel (CTSB, vWF, C9, and MFGE8) was established with promising diagnostic potential for the DCM. Collectively, our data provide a global proteomic basis of the chamber‐specific cardiac tissue, and establish a protein catalog that holds promise for better definition and diagnosis of DCM.