bluuebunny/crossref_metadata_2025_split huggingface dataset:
The CsHSFA‐CsJAZ6 module‐mediated high temperature regulates flavonoid metabolism in Camellia sinensis
Authors: Zhang Xueying , Li Linying , He Yuqing , Lang Zhuoliang , Zhao Yao , Tao Han , Li Qingsheng , Hong Gaojie 
Published: May 2023

AbstractHigh temperatures (HTs) seriously affect the yield and quality of tea. Catechins, derived from the flavonoid pathway, are characteristic compounds that contribute to the flavour of tea leaves. In this study, we first showed that the flavonoid content of tea leaves was significantly reduced under HT conditions via metabolic profiles; and then demonstrated that two transcription factors, CsHSFA1b and CsHSFA2 were activated by HT and negatively regulate flavonoid biosynthesis during HT treatment. Jasmonate (JA), a defensive hormone, plays a key role in plant adaption to environmental stress. However, little has been reported on its involvement in HT response in tea. Herein, we demonstrated that CsHSFA1b and CsHSFA2 activate CsJAZ6 expression through directly binding to heat shock elements in its promoter, and thereby repress the JA pathway. Most secondary metabolites are regulated by JA, including catechin in tea. Our study reported that CsJAZ6 directly interacts with CsEGL3 and CsTTG1 and thereby reduces catechin accumulation. From this, we proposed a CsHSFA‐CsJAZ6‐mediated HT regulation model of catechin biosynthesis. We also determined that negative regulation of the JA pathway by CsHSFAs and its homologues is conserved in Arabidopsis. These findings broaden the applicability of the regulation of JAZ by HSF transcription factors and further suggest the JA pathway as a valuable candidate for HT‐resistant breeding and cultivation.
Unwanted and unfollowed: Defining ghosting and the role of social media unfollowing
Authors: Collins Tara J. , Thomas Angela‐Faith , Harris Emma 
Published: May 2023

AbstractGhosting involves terminating communication, including through technological mediums, as a means of ending a relationship. Despite attention from popular media, empirical examinations of this breakup strategy are sparse. Using a correlational design, we examined the defining features of ghosting including its associations with other breakup tactics, whether it is an exclusively unilateral strategy, and the role of social media unfollowing in its implementation. A convenience sample of primarily undergraduate students (n = 260) completed an online survey describing recent breakups, indicating the disengagement tactics used, social media unfollowing, and the extent to which the breakups involved ghosting. Findings indicated that ghosting is extremely common, it was used to terminate more than half of participants' recent relationships. Most participants had experienced a breakup involving ghosting as either the disengager and/or the recipient. Ghosting was found to involve less open confrontation, more avoidance/withdrawal and de‐escalation tactics. Contrary to previous research, ghosting can occur bilaterally, with partners ghosting each other. Social media unfollowing is an important aspect of ghosting. Relationships ended via ghosting have fewer post‐breakup connections than those ended through other strategies. Typically, ghosters initiate social media unfollowing. Findings provide insight into how ghosting should be conceptualized and measured in future explorations.
An integrated analysis of mRNAs and lncRNAs in goat's hypothalamus to explore the onset of puberty
Authors: Gao Xiaoxiao , Ren Chunhuan , Zhang Wei , Fang Fugui 
Published: May 2023

AbstractThe time of puberty onset is crucial for female animal, as it can affect the generation interval, feeding costs and the utilization of animals. However, little is known about the mechanism of hypothalamic lncRNAs (long noncoding RNAs) in regulatory goat puberty onset. Therefore, genome‐wide transcriptome analysis was performed in goats to clarify the roles of hypothalamic lncRNAs and mRNAs in the onset of puberty. In the present study, the co‐expression network of differentially expressed (DE) mRNAs in goat hypothalamus identified FN1 as the hub gene, and ECM‐receptor interaction, Focal adhesion and PI3K‐Akt signalling pathways are involved in puberty. We also observed the crucial hub transcription factors (TCF12, STAT1, STAT2, GATA3 and TEAD4) associated with reproduction and puberty. Then, genetic correlation analysis of DE mRNAs and DE lncRNAs identified the key lncRNAs involved in puberty. This research supplies a resource for transcriptome studies in goat puberty and indicated DE lncRNAs in the ECM‐receptor interaction pathway were novel candidate regulators for genetic studies on female reproduction.
Dispersal of endolithic microorganisms in vesicular volcanic rock: Distribution, settlement and pathways revealed by 3D X‐ray microscopy
Authors: Schmid‐Beurmann Hinrich A. , Kahl Wolf‐Achim , Bach Wolfgang , Ivarsson Magnus , Böttcher Michael Ernst , Peckmann Jörn 
Published: May 2023

AbstractPleistocene basanitic rocks of Vesteris Seamount in the Greenland Sea had been found to exhibit an endolithic habitat largely consisting of marine fungi that dwell within abundant vesicles, therefore representing cryptoendoliths. For the first time, we demonstrate that 3D X‐ray microscopy can unravel how microorganisms access and migrate through vesicular rock. The fossil assemblages occur within a set of vesicles connected by microcracks. Such microcracks, which are ubiquitous features in submarine volcanic rocks, enable the dispersal of marine microorganisms in the rock. This study suggests that this pathway for the colonization of marine volcanic rocks forms in consequence of early tensional stress due to variable rates of cooling of the lava flow. Subsequently, the interconnected vesicles get populated by rock‐dwelling microorganisms. This cryptoendolithic habitat exists at least since the Paleoproterozoic.
Understanding tourists' travel behavior before, during, and after the trip with data from social media platforms
Authors: Mou Naixia , Wang Yanci , Zheng Yunhao , Zhang Lingxian , Makkonen Teemu , Jiang Qi , Yang Tengfei 
Published: May 2023

AbstractAnalyzing tourists' travel behavior at different stages of a trip can help to better understand their travel demands, providing valuable suggestions for destination management. In this article, we propose a research framework that can help in comprehensively analyzing tourists' travel behavior from the perspective of the three main stages: before, during, and after the trip. A case study was conducted based on user‐generated content data from the Old Town of Lijiang to verify the feasibility of the proposed research framework. The results show that: (1) before the trip, tourists inquire about destinations and optimal stay; (2) during the trip, tourists are attracted to natural sceneries; (3) after the trip, tourists discuss experience and services. Travel behavior in stages provide detailed (inter‐, intra‐, and individual attractions) guidance (from tourists) for destinations. The proposed framework provides a novel perspective for exploring the spatiotemporal behavioral features of tourists at different stages of their trips.
Genetic disruption of mammalian endoplasmic reticulum‐associated protein degradation: Human phenotypes and animal and cellular disease models
Authors: Badawi Sally , Mohamed Feda E. , Varghese Divya Saro , Ali Bassam R. 
Published: May 2023

AbstractEndoplasmic reticulum‐associated protein degradation (ERAD) is a stringent quality control mechanism through which misfolded, unassembled and some native proteins are targeted for degradation to maintain appropriate cellular and organelle homeostasis. Several in vitro and in vivo ERAD‐related studies have provided mechanistic insights into ERAD pathway activation and its consequent events; however, a majority of these have investigated the effect of ERAD substrates and their consequent diseases affecting the degradation process. In this review, we present all reported human single‐gene disorders caused by genetic variation in genes that encode ERAD components rather than their substrates. Additionally, after extensive literature survey, we present various genetically manipulated higher cellular and mammalian animal models that lack specific components involved in various stages of the ERAD pathway.
Conventional fractionated radiotherapy outcomes for young dogs with nephroblastoma of the spinal cord: 5 cases
Authors: Kim Jaeyoung , Kent Michael Sean , Théon Alain Pierre , Lejeune Amandine Tamara , Hansen Katherine Sarah 
Published: May 2023

AbstractPublished radiotherapy results for spinal nephroblastomas in dogs are limited. In this retrospective longitudinal study (1/2007–1/2022), five dogs with a median age of 2.8 years received post‐operative 3D conformal, conventional fractionated radiotherapy (CFRT) with 2–4 fields (parallel‐opposed with or without two hinge‐angle fields), for an incompletely resected nephroblastoma. Clinical findings prior to surgery included one or more of the following: pelvic limb paresis (5), faecal incontinence (2), flaccid tail (1), non‐ambulatory (2) and deep pain loss (1). All masses were located between T11 and L3 and surgically removed via hemilaminectomy. Dogs received 45–50 Gray (Gy) in 18–20 fractions, and no dogs received chemotherapy post‐radiation. At analysis, all dogs were deceased, with none lost to follow‐up. The median overall survival (OS) from first treatment to death of any cause was 3.4 years (1234 days; 95% CI 68 days‐upper limit not reached; range: 68–3607 days). The median planning target volume was 51.3 cc, with a median PTV dose of 51.4 Gy and median D98 = 48.3 Gy. Late complications or recurrence was difficult to fully determine in this small dataset; however, some degree of ataxia persisted throughout life in all dogs. This study provides preliminary evidence that post‐operative radiotherapy may result in prolonged survival times dogs with spinal nephroblastomas.
On the derivatives of Hardy's function Z(t)
Authors: Bui Hung M. , Hall Richard R. 
Published: May 2023

AbstractLet be the th derivative of Hardy's ‐function. The numerics seem to suggest that if and have the same parity, then the zeros of and come in pairs that are very close to each other. That is to say that has constant sign for the majority, if not almost all, of values . In this paper, we show that this is true a positive proportion of times. We also study the sign of the product of four derivatives of Hardy's function, .
Non‐abelian simple groups which occur as the type of a Hopf–Galois structure on a solvable extension
Authors: Tsang Cindy (Sin Yi) 
Published: May 2023

AbstractWe determine the finite non‐abelian simple groups which occur as the type of a Hopf–Galois structure on a solvable extension. In the language of skew braces, our result gives a complete list of finite non‐abelian simple groups which occur as the additive group of a skew brace with solvable multiplicative group.
Tuning Buckling Behaviors in Magnetically Active Structures: Topology Optimization and Experimental Validation
Authors: Zhao Zhi , Wang Chao , Zhang Xiaojia Shelly 
Published: May 2023

Abstract
Buckling, a phenomenon historically considered undesirable, has recently been harnessed to enable innovative functionalities in materials and structures. While approaches to achieve specific buckling behaviors are widely studied, tuning these behaviors in fabricated structures without altering their geometry remains a major challenge. Here, we introduce an inverse design approach to tune buckling behavior in magnetically active structures through the variation of applied magnetic stimuli. Our proposed magneto-mechanical topology optimization formulation not only generates the geometry and magnetization distribution of these structures but also informs how the external magnetic fields should be applied to control their buckling behaviors. By utilizing the proposed strategy, we discover magnetically active structures showcasing a broad spectrum of tunable buckling mechanisms, including programmable peak forces and buckling displacements, as well as controllable mechano- and magneto-induced bistability. Furthermore, we experimentally demonstrate that multiple unit designs can be assembled into architectures, resulting in tunable multistability and programmable buckling sequences under distinct applied magnetic fields. By employing a hybrid fabrication method, we manufacture and experimentally validate the generated designs and architectures, confirming their ability to exhibit precisely programmed and tunable buckling behaviors. This research contributes to the advancement of multifunctional materials and structures that harness buckling phenomena, unlocking transformative potential for various applications, including robotics, energy harvesting, and deployable and reconfigurable devices.
Post-COVID mRNA-vaccine IgG4 shift: worrisome?
Authors: Kadkhoda Kamran 
Published: May 2023

ABSTRACT
COVID-19 vaccines play a key role in ending the pandemic. Unraveling the immunological phenomena involved in offering protective immunity is the cornerstone of achieving such success. This perspective evaluates the possible mechanisms and implications of IgG4 production in response to mRNA-based COVID-19 vaccines.
Stability of Carbonates during Subduction: Influence of the Dehydration Regime of Chlorine-Bearing Metapelite
Authors: Sokol A. G. , Kruk A. N. , Palyanov Yu. N. 
Published: May 2023

Abstract
It was shown that, at a pressure of 3.0, 5.5, and 7.8 GPa and a temperature of 750–1030°C, a set of reactions occurred in carbonate and Cl-bearing pelite that is finally converted into an eclogite-like assemblage and formed a H2O–CO2 Cl-bearing fluid. The eclogite-like assemblage remains stable when the P–T conditions change concordantly with hot subduction geotherms, whereas carbonate is completely dissolved in the fluid already at ≥5.5 GPa. The CO2 content in the quenched fluid reaches 20–30 wt %. However, preliminary defluidization of pelite at 3.0 GPa and 750°С leads to chlorine removal and carbonate stabilization at 5.5 GPa and at 7.8 GPa in equilibrium with the next chlorine-free portions of the fluid. Comparison of the data available for simplified model systems and new data on carbonate and Cl-bearing pelite indicate that chlorine fluid essentially contributes to carbonate dissolution in the fluid. Thus, the stability of carbonates under P–T conditions typical of subduction zones is dependent on the behavior of chlorine during defluidization of marine sediments.
Geochemical Aspects of the Frictional Melting of Metapsammites during Seismic Slips (with Reference to Pseudotachylytes of the Ladoga Region)
Authors: Morozov Yu. A. , Matveev M. A. , Skublov S. G. , Smulskaya A. I. , Terekhov E. N. , Larkov A. S. 
Published: May 2023

Abstract
Based on analytical data on the geochemistry of tectonic pseudotachylytes and their host rocks, the specific trends of redistribution of major, trace, and rare earth elements in the course of seismogenic frictional melting of the arkosic metaterrigenous rocks from three zones of regional metamorphism with different temperatures (greenschist, amphibolite, and granulite) in the Northern Ladoga region are discussed. Oppositely directed trends of changes in the contents of the oxides of major elements in the protolith–blastocataclasite–pseudotachylyte triad were revealed, and a unidirectional increase in the basicity of the frictional melt as compared with the protolith was established at the same time. Geochemical evidence for partial selective melting of the protoliths is discussed. The specific features of the fractionation of trace and rare-earth elements during the transition of the protolith into the melt, as well as during its subsequent partial recrystallization, are shown. The emergence of a peak of elevated europium contents relative to the protolith in the melt matrix of all three sampling points is noted. Based on changes in the concentrations of these elements in the zones of pseudotachylyte substrate generation and in the areas of its moving and injection, the estimates of their differential mobility during frictional melting in a dynamic slip zone are given.
Hetero- and Homogeneous States of Hydrocarbon Fluids in the Earth’s Interior: Evidence from the Study of Synthetic Fluid Inclusions
Authors: Balitsky V. S. , Setkova T. V. , Balitskaya L. V. , Golunova M. A. , Bublikova T. M. , Plotnikova I. N. , Aranovich L. Ya. 
Published: May 2023

Abstract
Based on experiments including in situ studies of the phase composition and states of aqueous–hydrocarbon fluids in synthetic inclusions in quartz, the thermometric data indicating a heterogeneous state of fluids at shallow, medium, and great depths of oil- and gas-bearing layers were obtained. It was shown that aqueous–hydrocarbon fluids with an oil content of ≥10 vol % remain heterogeneous even at depths of up to 10–12 km at temperatures of 250–290°С. As is evident from experiments, homogenization in such fluids was achieved at temperatures above 380–400°C. However, such temperatures have not yet been recorded in any of the real oil and gas basins of the world. The results of our studies allow us to hope for the discovery of homogeneous deep deposits of oil and other hydrocarbons in the future.
Transformation of Malacological Fauna of the Sea of Azov in the Holocene and Its Role in the Formation of Coastal Spits
Authors: Matishov G. G. , Kovalenko E. P. , Titov V. V. 
Published: May 2023

Abstract
The study and analysis of malacofauna from cores of bottom sediments and cores of the Azov spits showed the nature of the change during the transition from the Ancient Azovian to the New Azovian layers and the uneven distribution of communities in time and space. Shell material from littoral malacocenosis and shallow-water banks is the main component for the formation of spits. Based on a series of cores up to 25 m thick from the Dolgaya Spit, it is shown that its formation began about 2500 years ago, and carbonate material reflects the history of the development of the benthic fauna of the sea.
Isotope Sm‒Nd Characteristics of the Juvenile Crust in the Central Mongol–Okhotsk Orogenic Belt
Authors: Dril S. I. , Kuzmin M. I. , Noskova Ju. V. , Zarubina O. V. 
Published: May 2023

Abstract
In the Phanerozoic, the production of continental crust was associated with convergent geodynamic settings [1] and, therefore, with intracontinental orogenic belts developed after the closure of paleooceans. Evaluation of the proportions of the juvenile crust versus older recycled material is a key parameter for understanding how the crust in orogens formed and evolved. The Mongol–Okhotsk orogenic belt is one of the major structural parts of Central Asia. Its central (Transbaikalian) part contains well-reserved fragments of an island-arc system, as well as the entire spectrum of accretionary prism formations, allowing us to evaluate the proportions of juvenile versus recycled sedimentary material in the crust of this orogen. In this part of the belt, the most representative fragments of the juvenile crust are volcanogenic–sedimentary sequences of the Late Paleozoic Kamenka and Urtui formations. The former is an indicator of a subduction zone along the northwestern margin of the Mongol–Okhotsk Ocean, with a dip beneath the Siberian Paleocontinent, whereas the latter marks the subduction zone along the southeastern margin, with a dip beneath the Argun superterrane. The entire spectrum of compositions for volcanism of the Kamenka Formation, from basalts to rhyolites, is characterized by positive values of ɛNd(254 Ma) = +1.4–(+3.8) and by TNd(DM) = 896–920 Ma. Basalts of the Urtui Formation also have positive values of ɛNd(350 Ma) = +1.7–(+6.0) at TNd(DM) = 773–939 Ma. This gives us grounds to evaluate the characteristics of the juvenile crust of the Mongol–Okhotsk orogenic belt: it is characterized by positive ɛNd(t) and by model ages TNd(DM) < 1000 Ma. The composition of metasedimentary rocks from the accretionary wedge of the Mongol–Okhotsk orogenic belt is considerably dominated by older recycled crustal material, the likely source of which is Late Riphean rock complexes of the Argun superterrane.
Use, characteristics and influence of lay consultation networks on treatment-seeking decisions in slums of Nigeria: a cross-sectional survey
Authors: Onuegbu Chinwe , Harlock Jenny , Griffiths Frances 
Published: May 2023

ObjectivesTo describe the use, characteristics and influence of lay consultants on treatment-seeking decisions of adults in slums of Nigeria.DesignCross-sectional survey using a pre-piloted questionnaire.SettingsTwo slum communities in Ibadan city, Nigeria.Participants480 adults within the working age group (18–64).ResultsMost respondents (400/480, 83.7%) spoke to at least one lay consultant during their last illness/health concern. In total, 683 lay consultants were contacted; all from personal networks such as family and friends. No respondent listed online network members or platforms. About nine in 10 persons spoke to a lay consultant about an illness/health concern without intending to seek any particular support. However, almost all (680/683, 97%) lay consultants who were contacted provided some form of support. Marital status (OR=1.92, 95% CI: 1.10 to 3.33) and perceiving that an illness or health concern had some effects on their daily activities (OR=3.25, 95% CI: 1.94 to 5.46) had a significant independent association with speaking to at least one lay consultant. Age had a significant independent association with having lay consultation networks comprising non-family members only (OR=0.95, 95% CI: 0.92 to 0.99) or mixed networks (family and non-family members) (OR=0.97, 95% CI: 0.95 to 0.99), rather than family-only networks. Network characteristics influenced individual treatment decisions as participants who contacted networks comprising non-family members only (OR=0.23, 95% CI: 0.08 to 0.67) and dispersed networks (combination of household, neighbourhood and distant network members) (OR=2.04, 95% CI: 1.02 to 4.09) were significantly more likely to use informal than formal healthcare, while controlling for individual characteristics.ConclusionsHealth programmes in urban slums should consider engaging community members so, when consulted within their networks, they are able to deliver reliable information about health and treatment-seeking.