bluuebunny/crossref_metadata_2025_split huggingface dataset:
The NLRP3 inflammasome in alveolar macrophages promotes angiogenesis in intermittent short-duration reoxygenation which relieves chronic hypoxic pulmonary hypertension
Authors: Li Shaohua , Cai Yue , Shi Qixin , Lyu Qiang , Bai Yungang , Zhang Shuai , Ma Jin 
Published: March 2023

Abstract
High altitude pulmonary hypertension (HAPH) is a chronic progressive disease caused by the reconstruction of distal pulmonary arterioles caused by chronic hypoxia. Due to the limited effect of current protective measures for treating HAPH, we propose the use of intermittent short-duration reoxygenation and prove its effectiveness in protecting against HAPH in an animal model. However, the mechanism of relieving HAPH by intermittent short-duration reoxygenation still needs to be further clarified. Previous studies have shown that alveolar macrophages and the inflammatory response induced by the NLRP3 inflammasome play an important role in the development of hypoxic pulmonary hypertension. However, repeated hypoxia and reoxygenation may lead to increased levels of inflammation due to increased oxidative stress. Therefore, the purpose of this study was to examine the changes in alveolar macrophages and the NLRP3 inflammasome under intermittent short-duration reoxygenation and their role in the protective effect. The results showed that intermittent short-duration reoxygenation resulted in higher density of pulmonary vessel bed and higher expression of the NLRP3 inflammasome in lung tissues and alveolar macrophages than continuous hypoxia. In addition, the depletion of alveolar macrophages or inhibition of the NLRP3 inflammasome in the lung counteracted the protective effect of intermittent short-duration reoxygenation on HAPH. Based on these results, we suggest that alveolar macrophages and the NLRP3 inflammasome promote angiogenesis in intermittent short-duration reoxygenation-mediated protection against HAPH.
Computational Exploration of Cu(II)-en Chelate Catalyzed Hydrolysis of O-isopropyl methylphosphonofluoridate
Authors: Khan Md Abdul Shafeeuulla , Bhanuchander Nellore , Reddy Jaggavarapu Satyanarayana , Anna Venkateswara Rao , Ganguly Bishwajit 
Published: March 2023

Abstract
In contrast to un-catalyzed hydrolysis of organophosphorus (OP) compounds, metal ions or/and their complexes with chelating ligands shows catalytic effects in several ways depending upon the nature of the metal, ligand, substrate and medium. It is known that Cu(II)-en chelate containing copper complexes accelerate the hydrolysis of OP compounds. However, the mechanism for this rate enhancement in the Cu(II)-en chelate catalytic hydrolysis reaction of sarin remains unexplored. We have examined possible mechanisms involving a Cu(II)-en with hydroxide nucleophile for the reaction pathway of the hydrolysis of O-isopropyl methylphosphonofluoridate (sarin) computationally. The density functional (B3LYP) employed in this study has reproduced the experimental Gibb’s free energy of activation value 15.5 kcal/mol for alkaline hydrolysis of sarin. Earlier proposal of push-pull mechanism for metal ion chelate catalyzed hydrolysis of OP compounds has been found to be unfavourable in the present study. The role of water molecules in catalyzing the hydrolysis of sarin with Cu(II)-en chelate is crucial. The catalytic process involving Cu(II)-en chelate with one water molecule is the more plausible pathway to achieve the hydrolysis of sarin with Cu(II)-en chelate complexes.
Estimating appropriate disturbance timing for the population of an endangered butterfly inhabiting grassland patches in an agricultural landscape
Authors: Deto Hidenori , Miyashita Tadashi 
Published: March 2023

Abstract
It has been recognized that the timing of disturbance, in addition to its intensity and frequency, is important for the population dynamics of organisms because the impact of the disturbance depends on the life history stage at which it occurs. However, the effects of disturbance timing on consumer population dynamics have not been explored. This study simultaneously estimated the effects of mowing frequency and timing on the subpopulation dynamics of the endangered grassland butterfly, Plebejus argyrognomon. A two-year investigation of a metapopulation of P. argyrognomon consisting of approximately 150 habitat patches revealed that subpopulation size decreased with increasing mowing frequency, in addition to the positive effect of patch area and habitat connectivity. With the mowing frequency fixed at once per year, subpopulation size maximized when mowing occurred during the adult period in the previous generation, presumably due to reduced impact in the high-mobility adult stage. By mowing during this period, subpopulations were maintained at a several times increased level. It is suggested that disturbance timing should be incorporated into the conservation of metapopulations in human-managed landscapes.
Results on fractional integrodifferential equations with fractional boundary conditions by using a special type of operators over general Banach spaces with bounded approximation numbers
Authors: Harisa Samy A. , Faried Nashat , Vijayaraj V. , Ravichandran C. , Morsy Ahmed 
Published: March 2023

Abstract
We assess, the existence of solutions to a class of nonlinear fractional integro-differential equations with Atangana-Baleanu (AB)derivatives with fractional boundary conditions. The existence and uniqueness solutions are derived by suitable fixed point theorem. Futhermore, we present an implicit numerical scheme based on the trapezoidal method for obtaining the numerical approximation to the solution. Some examples are given to illustrate our analytical and numerical findings.
2020 MSC: 34A08, 34K37, 65L10.
Adsorption properties of P-(CM-β-CD/HPCS/KHA/AC) hydrogel for tetracycline hydrochloride
Authors: Song Jie , Wei Zhiqing , Chen Lijun , Li Xi , Niu Yuhua , Zhang Rong , Zhu Xiaoli 
Published: March 2023

Abstract
Amino functionalized porous hydrogel material P-(CM-β-CD/HPCS/KHA/AC) was synthesized by using polyacrylic acid as the carrier, including acetate cyclodextrin, hydroxypropyl chitosan, potassium humate and activated carbon from the perspectives of environmental protection, high removal rate, reusable and degradable. The gel materials before and after adsorption were characterized by FTIR, TG, XRD and XPS, and showed high adsorption capacity for the removal of antibiotic (tetracycline hydrochloride (TCH). At 298K and pH 4, the adsorption capacity of P-(CM-β-CD/HPCS/KHA/AC) hydrogel on TCH reached 98.36mg/g, and the removal rate was 68%. The adsorption behavior follows the quasi-second-order kinetic equation, which accords with the Langmuir model, and through electrostatic interaction, π-π conjugation and hydrogen bond interaction, the entropy increase, endothermic and spontaneous process is formed. The regeneration and degradability experiments of P-(CM-β-CD/HPCS/KHA/AC) hydrogel were carried out to verify its recycling performance and environmental protection.
Differentiation benign paroxysmal positional vertigo from vestibular migraine via walking stability analysis: a cross- sectional and machine-learning study
Authors: Hu Tianyi , Jiao Xin , Shao Qineng , Wang He , Sun Xuhong , Tian Liang , Yu Jing , Zhang Lei , Wang Jing , Gu Dongyun 
Published: March 2023

Abstract
Background
Current clinical methods of distinguishing benign paroxysmal positional vertigo (BPPV) and vestibular migraine (VM) are primarily based on medical history and characteristics of nystagmus lacking objective and precise techniques.
Methods
In this study, we developed a machine-learning-based approach to distinguish BPPV and VM via gait performance and walking stability analysis. 16 BPPV patients, 16 VM patients and 16 healthy participants performed 10m level over-ground walking trials at self-preferred speed while wearing accelerometers on the head, the trunk and the ankles. Gait spatial-temporal and walking stability characteristics, including acceleration root mean square (RMS), harmonic ratio (HR), amplitude variability (AV), step/stride regularity and gait symmetry, were statistically analyzed within three groups. Ten kinds of individual learning and ensemble learning models were trained to classify participants into the BPPV group, VM group and HC group, based on walking stability characteristics.
Results
Results showed that the walking speeds of VM and BPPV patients were lower than those of healthy participants. Head acceleration RMS in the AP axis, step regularity in the mediolateral (ML) and head vertical (VT) axes decreased in VM and BPPV patients compared with healthy participants. Simultaneously, acceleration RMS in the ML axis of the head, AV in the VT axes at the head and trunk and HR in the VT axis of both head and trunk showed differential significance between VM and BPPV patients. The random forests (RF) model showed better classification performance with 83.9% accuracy and 0.854 AUC.
Conclusions
This study demonstrates the feasibility of distinguishing VM and BPPV based on walking stability parameters and machine learning models.
Unsupervised feature extraction and clustering of aerial images for understanding hazardous road segments
Authors: Francis John , Bright Jonathan , Esnaashari Saba , Hashem Youmna , Morgan Deborah , Straub Vincent J. 
Published: March 2023

Abstract
Satellite and aerial image data are becoming more widely available, and analysis techniques based on supervised learning are advancing their use in a wide variety of remote sensing contexts. However, supervised learning requires training datasets which are not always available or easy to construct. In this respect, unsupervised machine learning techniques present important advantages. This work presents a novel pipeline to demonstrate how available aerial imagery can be used to better the provision of services related to the built environment, using the case study of road traffic collisions (RTCs) across three cities in the UK. In this paper, we show how aerial imagery can be leveraged to extract latent features of the built environment from the purely visual representation of top-down images. Through the clustering of hazardous road segments with these latent image features, this work demonstrates how aerial images and machine learning can provide a data-driven aid for road safety experts to enhance their nuanced understanding of how and where different types of RTCs occur.
Electric Vehicle in Distribution Grids
Authors: Sezar Volkan 
Published: March 2023

Abstract

With the presence of Electric Vehicles (EV’s) in the distribution grid as a load, grid losses increase dramatically, which can have adverse effects on parameters such as deployment, cost, profit, etc. But if EV’s are connected to the grid, by managing their charging and discharging, positive effects can be created in the load curve and grid losses can be reduced. In this paper, the effect of the presence of different types of EV’s with different capacities and the absence of EV’s on grid losses have been compared with each other considering the daily load curve. The simulation in DIGSILENT software has been done on a 74-bus distribution grid with IEEE standards considering and with 1000 vehicles. The results show well the effect of EV’s charging and discharging on grid losses.
Vinegars from fruits of Myrciaria cauliflora (Mart.) O.Berg and Myrciaria jaboticaba (Vell.) Berg: Phytochemical, volatile and, sensory profiles, antioxidant activity and chemical characteristics
Authors: Pagliarini Cesar Luiz , Pagliarini Mateus Alcides , Santos Viviane Aparecida Figueredo Oliveira , Steffens Cristiano André , Hoff Rodrigo Barcellos , Dognini Jocinei , Crestani Ilene , Dacoreggio Marina Volpato , Bagatini Lucíola , Kempka Aniela Pinto 
Published: March 2023

Abstract
Jabuticaba is a tasty Brazilian fruit, with high productivity and perishability, with a short period of consumption after harvest. For a better use of its production, an alternative is the production of derivatives, such as vinegar. This study aimed to determine the phenolic, volatile and, sensory profiles, antioxidant activity and chemical characteristics of vinegars produced with fruits, with and without peel, of Myrciaria cauliflora (Mart.) O. Berg and Myrciaria jaboticaba (Vell.) Berg. Four vinegars were obtained. Fourteen phenolic compounds were identified and quantified, classified between phenolic acids and flavonoids, with emphasis on 3,4-DHB, chlorogenic acid and, sinapic acid. The highest antioxidant activity was for M. jaboticaba vinegar, made with unpeeled fruits. For volatile compounds, 21 esters, 7 alcohols, 5 terpenes, 1 ketone, and, 1 vinylarene were identified. Sensory analysis showed similarities in terms of taste and differences in terms of odor between Jabuticaba vinegars and commercial vinegars. Phenolic compounds, acetic acid and, esters were the main chemical groups identified. Vinegars, in general, showed differences regarding the presence and absence of peels. The jabuticaba vinegars showed characteristics suitable for the product, and several important compounds for human health.
Differential Diagnosis of Adrenal Adenomas and Metastases Using Spectral Parameters in Dual-layer Detector Spectral CT
Authors: Wu Lei-di , Yue Xiao-fei , Wu Lin-xia , Yang Ming , chen Yan , Yu Jie , Diao Nan , Zhang Xiao-hui , Zhu Liang-ru , Han Ping 
Published: March 2023

Abstract
Objective
To assess the diagnostic value of spectral parameters in differentiating adrenal adenomas from metastases based on dual-layer detector spectral CT (DLSCT).
Materials and methods
Patients with adenomas or metastases who underwent enhanced DLSCT of the adrenals were enrolled. The CT values of virtual noncontrast images (CTVNC), iodine density (ID) values, and Z-effective (Z-eff) values, the normalized iodine density (NID) values, slopes of spectral HU curves (s-SHC), and iodine-to-CTVNC ratios of the tumors were measured in each phase. Receiver operating characteristic (ROC) curves were used to compare the diagnostic values.
Results
Ninety-nine patients with 106 adrenal lesions (63 adenomas, 43 metastases) were included. In the venous phase, all spectral parameters were significantly different between adenomas and metastases (all p < 0.05). The combined spectral parameters showed a better diagnostic performance in the venous phase than in other phase (P < 0.05). The iodine-to-CTVNC value had a larger area under the ROC curve (AUC) than the other spectral parameters in the differential diagnosis of adenomas and metastases, with a diagnostic sensitivity and specificity of 74.4% and 91.9%, respectively. In the differential diagnosis of lipid-rich adenomas, lipid-poor adenomas and metastases, the CTVNC value and s-SHC value also had a larger AUC than the other spectral parameters, with a diagnostic sensitivity of 97.7%, 79.1% and specificity of 91.2%, 93.1%, respectively.
Conclusion
On DLSCT, the combined spectral parameters in the venous phase could help better distinguish adrenal adenomas from metastases. The iodine-to-CTVNC, CTVNC and s-SHC values had the highest AUC values in differentiating adenomas, lipid-rich adenomas and lipid-poor adenomas from metastases, respectively.
Patients’ handling tasks, awkward postures and work-related musculoskeletal disorders among nursing staff in critical care-units
Authors: Mebarki Bouhafs , Zaoui Brahim , Mokdad Mohamed , Mebarki Imededdine 
Published: March 2023

Abstract
Background
Awkward postures imposed by nursing duties are a main source of work-related musculoskeletal disorders among nursing staff. The purpose of this article is to describe the prevalence of work-related musculoskeletal disorders among critical care nurses, in two patient handling tasks, transferring and repositioning of patients, and assess their training level and acquaintance of ergonomics rules and principles in patients’ handling tasks.
Materials & Method
This study was conducted among caregivers in a hospital critical care-unit. Aged: 25–55 years, (X = 35.5, SD: 9.56), with a seniority range of 5 to 25 years (X = 14.9, SD = 8.92), and a mean working time of 48 hours a week (8 hours/day), distributed among day, night and irregular shift of 3, 3 and 4 nurses each shift, respectively. For screening the musculoskeletal disorders among caregivers in intensive care, an adapted version of previous instruments was used to collect data. The adopted instrument consisted of a questionnaire, a subjects’ assessment figure and a video recording system.
Results
results of the study revealed a large number of nurses in intensive care unit exhibit musculoskeletal disorders symptoms. Nurses knowledge of safe patients handling technics are superficial and lacking basic human factors /ergonomics principles.
Conclusions
The study recommended the immediate hiring of an adequate number of physically able nursing staff and providing the necessary work equipment to assist nurses perform patient handling tasks. In the near future, a human factors/ergonomics intervention program should be launched, incorporating a “Safe Patient Handling Training Program” for the critical care-unit staff.
Vertical jump and relative strength are strongly associated with change of direction in professional male basketball players
Authors: Benítez-Flores Stefano , Lusa-Cadore Eduardo , Stojanović Emilija , Delextrat Anne , Calleja-González Julio 
Published: March 2023

Abstract
Background
Change of direction (COD) ability it is an essential component in modern basketball competition. However, the predictors of COD have not yet been clearly established.
Aims
The aim of this study was to examine the predictors of COD in highly trained/national level male basketball players using field assessments.
Methods
Eight professional male basketball players (age: 24.0 ± 5.5 years; body mass index (BMI): 24.05 ± 1.65 kg·m− 2) volunteered for participation in this study. All the evaluations were carried out during 2 sessions as follows: First day_1) body composition, 2) unilateral and bilateral squat jump (SJ) and countermovement (CMJ), and 3) Yo-Yo intermittent recovery test level 1 (Yo-Yo IR1); Second day_1) COD performance, and 2) one repetition maximum (1RM) hang clean (HC) and bench press (BP). A linear regression was performed to evaluate the determinants of COD amongst all other measured variables. Furthermore, we applied Pearson correlation coefficient and in the case of non-normal variables, Spearman's correlation coefficient for the selected variables.
Results
The linear regression indicated that only SJ height was a significant determinant of COD (R2 = 58.8%, p = 0.016). Significant correlations were identified between COD test with SJ (r= -0.75, p = 0.034; very large), and relative HC 1 RM (r= -0.74, p = 0.038; very large).
Conclusions
The associations found between COD performance and physical parameters should be considered when developing athletic conditioning programs.
Water Quality Investigation and Pollution Estimation of Groundwater Related to Reservoir Water Along the Main Stream in Geum River Basin, Korea
Authors: Choi Hanna , Koh Dong Chan , Yoon Yoon Yeol 
Published: March 2023

Abstract
This study aims to identify spatially water quality distribution of groundwater and surface water in reservoirs, and comprehensively to address possible influencing factors. The concentration of NO3 in the reservoirs along the main stream of the Geum River was generally lower than that in groundwater. The pollution level of the reservoir, especially the particulate pollutant SS, clearly showed seasonal variations and increased significantly downstream. The H-3 concentration of the groundwater was high in the plains and low in the mountain areas, indicating a difference in residence time between the two regions. The hydrochemical properties and factor loading values of the principal components indicated that the major factors were water‒rock interactions and residence time, but a positive correlation of K-NO3 and Mg-Cl showed the influence of agricultural activities. The main groundwater pollutants were likely to be contributed by agricultural activities at upstream and seawater infiltration at downstream. The sensitive redox species uranium in the groundwater of this region existed as the uranyl ion, and it showed a positive correlation with HCO3, pH, and Ca. The results emphasize the importance of monitoring both tributaries and groundwater together in order to effectively manage the water quality of the Geum River basin.
Synthesis pure ETS-10 by optimization synthesis parameters using One Factor At a Time (OFAT) approach: CO 2 adsorption study
Authors: Khademi Amirhossein , Babakhani Ensieh Ganji , Darian Jafar Towfighi , Mahdipoor Hamid Reza 
Published: March 2023

Abstract
In this work, ETS-10 was synthesized by hydrothermal method. The effect of synthesis parameters of ETS-10 on purity and characterization was studied by One At a Time (OFAT) approach. According to this approach, in each test, one synthesis parameter was changed while the other parameters were kept constant. All samples were identified by PXRD and the purest sample was characterized by SEM, EDX, BET, and TGA/DTA. To evaluate the CO2 capture abilities of the synthesized purest sample, CO2 adsorption isotherm at 298 K was obtained by the constant-volume adsorption method. The isotherm models Dual-site Langmuir, Toth, and UNILAN were used to fit the obtained isotherm data. The results showed that with gel pH = 11.3, crystallization temperature 230°C, and crystallization time 72 h, the ETS-10 with the highest purity was achieved. Also, it was observed that there is an important interaction between the potassium source with other synthesis parameters. The adsorption results showed that the CO2 adsorption capacity of the pure ETS-10 was 3.37 mmol/g. It was observed that the Dual-site Langmuir model was fitted better the CO2 adsorption data at 298 K compared to Toth and UNILAN models. The adsorption kinetics showed that about 90% of the equilibrium adsorption was reached within 25s which demonstrates a remarkable fast kinetics.
Investigation of Solvent Effect and H-Bonding on Spectroscopic Properties of 1-(3-Amino- 6-(2,5-dichlorothiophen-3-yl)-4-phenylfuro[2,3-b]pyridin-2-yl) ethenone: Experimental and Computational Study
Authors: Abufaha Rasha K. , Yousef Fakhri O. , Ghanem Raed , Al-Sou’od Khaldoun , Shahdi Ihsan A. , Almashaqbeh Omar K. , Al-Refai Mahmoud 
Published: March 2023

Abstract
The furo[2,3-b]pyridine moiety is an important scaffold for many biologically active compounds, therefore, the spectral data of the derivative 1-(3-Amino-6-(2,5-dichlorothiophen-3-yl)-4-phenylfuro[2,3-b]pyridin-2-yl) ethenone (FP1) were investigated. Analysis of absorption-pH profile and Förster cycle of FP1 revealed that its excited state is more acidic than its ground state (pKa * <pKa). The main fluorescence emission band of FP1 at 480 nm (in hexane) is shifted to longer wavelengths with increasing polarities of solvents. Linear Lippert’s plot and linear correlation between bands maxima and Camlet-Taft parameter, α, of the protic solvents indicated efficient intramolecular charge transfer and noticeable H-bonding. Moreover, the disappearance of the absorption band of FP1 at 385 nm in water, along with the noticeable red shift and quenching of the emission band, and the lower lifetime, relative to nonaqueous solvents, indicate the interruption of the furo[2,3-b]pyridine aromatic moiety. In addition, results from the Time Dependent Density Functional Theory (TDDFT) and Molecular Mechanic (MM) calculations were in agreement with experimentally determined spectra of FP1.