bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preparation and In-Vitro Evaluation of Floating Oral In- Situ Gel of Montelukast Sodium (Conference Paper) #
Authors: Adnan Manar , RoaaA.Nief  , Shaimaa Nazar Abd-Al Hameed  , Haneen Abdulhadi Kharaba  
Published: June 2023

There were several goals in this study, the most important of which was to create an oral liquid preparation (Ion sensitive floating oral in situ gel system for sustained delivery of Montelukast Sodium for pediatric patients) that would make administration easier, provide the correct therapeutic dose, and allow the drug to be released more slowly into the digestive tract (GIT) for better control.
Montelukast Sodium in situ gels at different concentration (w/v) of natural polysaccharides (Gellan gum and sodium alginate) and natural polymer (Pectin) were prepared and characterized in the terms of preparation, viscosity and In vitro release.
As the concentrations of ion-sensitive gel-forming components (Gellan gum, sodium alginate, and pectin) and gas-generating ingredients increased, the viscosity of formulations in solution (CaCO3). In vitro release study showed that the release of Montelukast Sodium from these gels was characterized by an initial phase of high release (burst effect), followed by a more gradual release in the second phase.
The oral distribution of Montelukast Sodium using the in situ gel system manufactured by Montelukast Sodium can be seen as a viable strategy for the improvement of therapeutic effects.
Autophagy or Apoptosis: Anticancer Molecular Mechanism of Epigallocatechin Gallate with Natural Polyphenol Effect on HepG2 Cells Viability
Authors: Hafidh Rand R. , Ali Zahraa Q. , Abdulamir Ahmed S. 
Published: June 2023

Background: The anticancer impact of Epigallocatechin gallate (EGCG) the highly active polyphenol of green tea was abundantly studied. Though, the exact mechanism of its cytotoxicity is still under investigation. Objectives: Hence, the current study designed to investigate the molecular target of EGCG in HepG2 cells on thirteen autophagy- and/or apoptosis- related genes. Methods: The apoptosis detection analyses such as flow cytometry and dual apoptosis assay were used. The genes expression profile was explored by the real-time quantitative-PCR. Results: EGCG increases G0/G1 cell cycle arrest and the real-time apoptosis markers proteins leading to stimulate apoptosis in 70% of the treated HepG2 cells. The up-regulation was recorded in two of autophagy inhibitory genes (FOS-1, FOS-2) and apoptosis inducer gene (DDIT3). While the other ten genes expressed down-regulation after treatment. The down regulation was manifested in the genes of mitochondrial autophagy marker proteins (BNIP3, BNIP3L, and NBR1), the autophagy regulator genes (BIRC5, MAPK9), and the gene that implicated in protein biosynthesis and protein modification (ITGB1). The genes that have pro-apoptotic function in cells (CAPNS1, CFLAR, EIF4G, and RB1) were also showed down-regulation after treatment. Conclusion: Thus, the results demonstrated a potential effect of EGCG to induce apoptosis rather than autophagy in the treated HepG2 cells that could play a good target for therapy.
I as Collage: Playwright John Ng on the Modern Immigrant Experience
Authors: Yap Jennifer 
Published: June 2023

“Asian American experience is a relatively new concept if you think about it. We only go back 20-30 years, so we have all of those issues to work through – chief of which is the immigrant experience. Writers need to get this out of their system. It’s their most immediate experience of all; growing up, family, generations, racism, gender. We have to get through that before we start getting into all the other iterations of American life. It takes a certain amount of maturity as a writer to hone in on the nitty gritty of relationships and look at other situations, and as we develop Asian American theatre that’ll happen.” -Ralph B. Peña (Eng 4l6)
Theatre in Atlantic Canada: “Myth-Making and Myth-Challenqinq”
Authors: Burnett Linda 
Published: June 2023

In an interview that was published in 1991, Wendy Lill had this to say about the state of theatre in Atlantic Canada: In the East, I find, as with everything else, a sense of reticence. It’s not insecurity, because there’s certainly a great deal of pride here: people who are here want to be here. It’s more a feeling that’s been drummed into Easterners for decades that historically “East is Least” and that their stories aren’t as interesting as those from the West. At least not to anyone who isn’t an Easterner. (Rudakoff 37)
All Roads Lead from Mulgrave (Road Theatre)
Authors: Rhindress Charlie 
Published: June 2023

Last fall I directed the world premiere of Jenny Munday’s Relatively Harmless at Live Bait Theatre in Sackville, New Brunswick, where I’m the artistic director. Watching one of the final rehearsals, I thought to myself, “Wow, that’s Gay Hauser and John Dartt on stage in my theatre.“ I felt privileged to be working with two artists who had helped establish indigenous Maritime theatre; two artists who were instrumental in the early days of the Mulgrave Road Theatre Co-op; two artists who I made coffee for in one of my first profession al theatre gigs.
Remembering Herbert (c. 2006)
Authors: Breon Robin 
Published: June 2023

These eloquent words begin Herbert Whittaker’s account of Montreal theatre from 1920 through 1949, as detailed in his book, Setting the Stage. This text, along with two earlier books, Whittaker’s Theatre 1944—1975 and Whittaker’s Theatricals should be required reading for every drama student in the country. I firs t met Herbert - (I won’t use the diminutive “Herbie” here although it was almost universally applied by most of his friends. Whenever I would receive a message on my voice mail from him it was always: “This is Herbert give me a call when you get a chance .“And I think , if the truth were known, he preferred it ) - in the early 1970s when we formed an organization of theatre critics and writers called the Toronto Drama Bench. The arts patron, Floyd Chalmers, had given a sum of money for an endowment to encourage excellence in dramatic writing, and there needed to be some body to adjudicate the award. Herbert was then the drama critic for the Globe and Mail and I was writing for a small, left-Wing “underground” newspaper of the period called Guerilla. In chatting after the meeting, Herbert noted that he was the senior (meaning oldest) member of the organization and that I was the youngest and that therefore we should try to get along. We did that in a friendship that lasted over thirty years. During that time, (lost my status as youngest member of the organization, but some how he remained our elderst atesman.
Tiny Heartbreaks and the Electric Creative Body
Authors: Drew Noah 
Published: June 2023

There were a few years there where I kept getting my heart broken. In the theatre. Doing sound design gigs. The basic scenario would go som ething like this. I’m hir ed by a theatre company to do a sound design. It ’s an attractiv e company; maybe it’s a sexy young thing, an avant-garde typ e. Or maybe it’s a little older, distinguished , with a sens e of class and a heftier wall et . In either case, a company I’m flatt er ed to spend a little t ime with.
De/Constructing Queer Representation on the Rez
Authors: Schwartz Shira 
Published: June 2023

“Am I making you a little bit uncomfortable?” Unfortunately, Jake, no. You’re not. Or, at least, no more uncomfortable than we ought to be. This was my reaction at the end of Waawaate Fobister’s solo show when ref1ecting on the protagonist’s key question. While visually and theatrically impressive, never once did Fobister’s performance make me stir, fidget or squirm in my seat, leading me to call into question the extent to which this production pushes social and political boundaries in a significant way.
Making the Grade: Professional Association of Canadian Theatres Web Site Assessment Research Project
Authors: Prendergast Monica 
Published: June 2023

In the twenty-first-century world of theatre-going, an audience member’s first point of contact with a theatre company is more and more likely to be the company’s web site. This small-scale research project was interested in surveying the web sites of the 106 full members of the Professional Association of Canadian Theatres [PACT]. (Affiliate members who might not have full seasons or operating budgets for web site development and upkeep were excluded.) The dual purposes of this survey were the following: to assess PACT members’ web sites based on a list of twenty-five yes/no questions ranging from information available on current and past seasons to ticket sales, media resources, educational resources and other evaluative criteria, as seen in the results presented below. to pay attention to how much interactivity was in evidence on each site; that is, to how PACT members’ web sites invite potential and/or actual audience members to engage with their productions, artists, administrations; that is, what spaces or places are made available for theatre-goers to find out more about or respond to a company, its season, or a particular show?
Newhouse
Authors: Rose Richard , Kugler D. D. 
Published: June 2023

Newhouse is a speculation about possible, but avoidable, future events – the political and social effects a sexually transmitted disease, at epidemic levels, could have on the individual and society. Any plague, but especially a sex plague, is a catalyst for radical change in human behaviour. Unfortunately, the fear and ignorance surrounding such a plague can be manipulated by political parties and religious groups to re-shape society. Fortunately, many organizations exist to inform the public, and their efforts not only abate the spread of the disease, but undercut the hysteria.
Why I Went North
Authors: Wyatt Rachel 
Published: June 2023

Why did you go North in the first place? I went there to find an inukshuk. I went there to find an inukshuk. The storm was still raging and the damaged boat was drawn up on the shore. The four people were out of food and there was no telling when the winds would settle and let them continue on their journey. A polar bear had been around for days, watching, waiting, and when it came snuffling round the tent that morning, the old hunter shot and killed it.
From Cultural Concerns to Community Action
Authors: Cardinal Donna 
Published: June 2023

An artist in Victoria makes his way to a corner of his cluttered studio, switches on the computer, logs on to the network, and reads and responds to the day’s postings by peer learners he is accompanying as they explore the issues of culture and cultural transformation in their communities across Canada. A museum director in a remote northern town sits back at the end of a busy day, logs on to the same network, and uploads an image he has been exploring in his own mind of a museum that speaks to today’s cultural and social issues. He is thinking of offering this image as a contribution to the province’s cultural policy development process.
Theatre and the Information Superhighway: A View from the Ivory Tower
Authors: Mullaly Edward 
Published: June 2023

I mentioned to a colleague the other day that I was writing a short paper on “Computers and Theatre”. His instant response was “Oh, are you for them or against them?” This alternative had not entered my mind. It doesn’t matterin the least whether we’re for or against them. Computers have become part of the fabric of our existence. They are the turbo chargers on the engine of research. While they allow us to do nothing that we could not do without them, they allow us to do it much more quickly. We could search through each issue of the MLA Bibliography for articles on Tennessee Williams, but it’s much quicker to have the computer talk to a CD-ROM. I could search through periodicals on Canadian theatre to find who has said what recently,butit’s more useful to enter citations into a data base which remains memory resident in my own computer. If I want to do textual analysis of Shakespeare’s plays, I could type the text into WordPerfect, but it’s much quicker to download the scripts from the Internet directly onto my hard drive. I’m justlabouring the obvious when Isay computers have moved us from an era of movable type to an era of movable information.
Confessions of Disguise/Disguises of Confession: Looking at Primus Theatre’s The Night Room
Authors: Mark Lisa Gabrielle 
Published: June 2023

Primus Theatre’s production of The Night Room is an articulation of space and body, of desire, of fear. Speaking what cannot be spoken. I enter a billowing tent that breathes and sighs, wandering around the maze-like corridors of the tent before I am seated. I have lost my sense of direction by now. The labyrinth pulsates. The audience is seated in a chamber inside the labyrinth, complicit. Warm with desire. Drawn in. (Quartered).
Cyber:\womb A contemporary domestic science-fiction drama in two acts
Authors: Laxdal Vivienne 
Published: June 2023

Playwright’s Note This play was inspired by my questions and concerns about reprod uctive technology and genetic engineering. My fascination with the Cyberpunk movement and my feehngs of being left behind or on the “outside” also came into creative play. I wonder about the context of “soul” within these new methods of creating and altering life. Is anybody thinking abou t that? Should we?
Black Community Submission... Montreal – Quebec into the 1990s
Authors: Bayne Clarence S. 
Published: June 2023

Excerpt from the Black Community Submission To The Committee On Culture Public Hearing on the Proposition de Politique de la Culture et des Arts Submitted to the National Assembly Secretaire de la Commission de la Culture Prepared by Dr Clarence S. Bayne for The Black Theatre Workshop of Montreal, Carifete, Afro-Festival of The Black Community Council of Montreal, Rhythme du Monde and The Foundation for the Minority Arts and Culture.1
Epilepsy & the Snake Fear in the Creative Process
Authors: Thompson Judith 
Published: June 2023

The text of a talk delivered by Judith Thompson at the Stratford Festival, 30 June 1996, as part of the Festival’s Celebrated Writers Series. Today I am going to talk for a while about pure fear and the loss of the self in the act of creation. Where are the eleven other Judiths? About ten years ago I woke up early one spring morning in a sta te of pure fear. For at least a minute, which seemed like foreve r, I was in a panic, trembling from head to toe, as I couldn’t remember where the eleven other Judit hs might be. Without them, I had no self. I was disappearing. Although psychologically I can attribu te this moment of ter ror to a cha nge in med icat ions, it gave me some insight into the psychological cost of the work that I do: the creation of other cha racte rs within a world that resembles our own, but, like Alice’s Wonde rla nd, is seen throu gh the looking glass, darkly.
Drama as Docufiction
Authors: Murphy Sarah 
Published: June 2023

Leila Sujir interviewed by Sarah Murphy with excerpts from Leila Sujir’s The Dreams of the Night Cleaners Murphy: In The Dreams of the Nightcleaners, your docufictive approach to your material - the combination of document, drama, fiction and fantasy in a multilayered fantasy - yields an extraordinarily rich and complex final product. How did you decide on this approach?
Perspectives from Playwrights Canada Press: An Interview with Angela Rebeiro
Authors: Ratsoy Ginny 
Published: June 2023

Angela Rebeiro is Executive Director of Playwrights Union of Canada and the publisher of Playwrights Canada Press, publishing imprint of the PUC. She has been with the organization since 1992. Ginny Ratsoy interviewed Angela Rebeiro in August of 1998 in Toronto. The interview was updated in early December.
The athleticism as a type of the motor activity of the applicants of the higher education: characteristics and effectiveness of the classes
Authors: Dakhno A. O. , Slobodianiuk O. V. 
Published: June 2023

Studying in the higher education institutions is characterised by intellectual stress and a decrease in the level of the physical activity among students, which is due to an increase in the time spent on educational activities.
The physical activity promotes health, improves the functional state of the systems, increases physical fitness and performance in the applicants of the higher education institutions. Its deficit has a negative impact on the physical condition of this contingent.
One of the effective types of physical activity and effective means of the physical education of the applicants in the higher education institutions is athletics.
Today, athletics is a popular form of the physical activity among the applicants og the higher education. The number of people involved in various types of artistic gymnastics is growing.
The purpose of the study: to characterise and reveal the effectiveness of systematic athletic training by the applicants of the higher education institutions. Research methods: theoretical analysis and generalisation of scientific and methodological literature.
Results of the study. The general characteristics of athleticism are considered. The effectiveness of systematic training in this type of motor activity by the applicants of the higher education institutions is studied.
Conclusions. Athleticism is a health-improving direction of bodybuilding, which is based on the use of complexes of physical exercises of power orientation with different burdens. Athletic gymnastics is an effective means of improving health, increasing the level of physical fitness and performance in the applicants of the higher education institutions.
Prospects for further research: to develop a programme for improving strength in the applicants of the higher education institutions by means of athletics.
Main directions of scientific research and implementation of modern information technologies in physical education and sports
Authors: Klopov R. , Klopova V. 
Published: June 2023

In the modern information society, information and communication technologies are rapidly developing and are used in various spheres of human activity. Well-known experts believe that scientific, industrial, business and educational technologies, as well as arts and sports technologies, are based on information systems. Therefore, issues related to the use of modern information and communication technologies in physical culture and sports and further research of this problem are very relevant. The purpose of the study is to systematize the main directions of using modern information technologies in the field of physical culture and sports.
It was established that the concept of «information system» can have a broad and narrow interpretation. In a broad sense, it covers the technical, software and organizational support and personnel created to provide users with the information they need. In a narrow sense, an information system is a collection of information contained in databases and providing its processing by information technologies and technical means.
The analysis of literary sources showed that the use of information technologies is of great importance for improving the training process and achieving better results in sports. Scientists from different countries are actively developing programs and technologies for collecting and analyzing training data, using various tools for recording and analyzing biomechanical parameters and data visualization. Systems for testing the physical condition and working capacity of athletes are also being developed. The use of such technologies can contribute to the development of domestic information technology systems for sports and recreation. It has been established that in the field of physical culture and sports it is possible to use information systems in the following areas: managerial, organizational and research activities; maintenance of sports competitions; sports training and training of athletes; informational and methodological support and management of the educational process in educational institutions and sports organizations; health physical culture; monitoring of physical condition, health and environment; psychodiagnostics in sports.
Features of motivation of university cadets with specific learning conditions for physical education
Authors: Kosheleva Elena , Veliky Yurii 
Published: June 2023

The article analyzes the motivational priorities for physical education classes of cadets studying at the Dnipropetrovsk State University of Internal Affairs in the specialty "Law" in order to determine ways to improve their psychophysical preparation for future professional activity. As a result of the study, low motivation and involvement of cadets in physical education was established; The external and internal factors influencing the formation of motivation of applicants to engage in physical culture are determined.
The authors propose an experimental scheme for improving the physical training of higher education students with specific learning conditions, compiled on the basis of taking into account their motivational priorities for physical education, external and internal factors that affect these priorities, features of their psychophysical state. Conducting any form of training will be more effective if the activities of cadets are motivated. In order to build an effective system for improving the physical training of university applicants for their future profession, the authors propose to take into account the dynamics of changes in the motives of applicants throughout the entire period of study at the university. The authors note that when planning and conducting practical classes, scientific and pedagogical staff should take into account the influence of the psychophysiological state of cadets on internal needs for incentives. The most optimal way to influence the motivation of university applicants to engage in physical culture and sports should be applied after studying the situational factors and personal characteristics of cadets. Significant levers of influence on the motivational priorities of applicants for physical culture and sports should be the practical experience of scientific and pedagogical workers, an emphasis on preparing for future professional activities, creating appropriate conditions for classes, forming a positive attitude and enjoying applicants from the classes held.