bluuebunny/crossref_metadata_2025_split huggingface dataset:
The impact of dual- versus single-dosing and fatty food co-administration on albendazole efficacy against hookworm among children in Mayuge district, Uganda: Results from a 2x2 factorial randomised controlled trial
Authors: Kim Eun Seok , Adriko Moses , Aidah Wamboko , Oseku Kabarangira Christine , Lokure David , Sabapathy Kalpana , Webb Emily L. 
Published: July 2023

Background
Mass Drug Administration (MDA) is the main strategy for control of soil-transmitted helminth (STH) infections, with single-dose benzimidazole (albendazole or mebendazole) the principal MDA option. In Mayuge district, Uganda, an MDA programme has been in place for over fifteen years but hookworm infection remains common and there is concern that the effectiveness of single-dose albendazole as currently used for MDA may be sub-optimal. This study aims to assess the efficacy of dual- versus single-dose albendazole, with and without fatty food co-administration against hookworm, the dominant form of STHs in Mayuge district, Uganda.

Methodology
This was a 2x2 factorial randomised controlled trial to investigate two interventions simultaneously; 1) dual-dose versus single-dose albendazole, 2) taking albendazole with or without fatty food (200 grams of avocado eaten directly after medication). School children with hookworm infection were randomised in a 1:1:1:1 ratio to the four possible treatment groups. Three weeks after the treatment, stool samples were collected from trial participants to evaluate trial outcomes: cure rate and egg reduction rate (ERR).

Principal findings
A total of 225 participants were enrolled, and 222 (98.7%) seen at 3 weeks. The cure rate in the dual-dose group was 96.4% (95% CI: 90.9–99%), higher than 83.9% (95% CI: 75.7–90.2%) in the single-dose group (OR: 5.07, 95% CI:1.61–15.96, p = 0.002). The ERR was 97.6% and 94.5% in the dual-dose group and single-dose drug group, respectively (ERR difference 3.1%, 95% CI: -3.89–16.39%, p = 0.553). The cure rates among participants taking albendazole with and without avocado were 90.1% and 89.1%, respectively, with no statistical difference between the two groups (OR: 1.24, 95% CI: 0.51–3.03, p = 0.622). The ERR was 97.0% and 94.2% in the group receiving albendazole with and without avocado, respectively, and the difference in ERR between the two groups was 2.8% (95% CI -8.63–14.3%, p = 0.629).

Conclusions/Significance
In Ugandan school children, dual-dose albendazole improves the cure rate of hookworm compared to single-dose albendazole. However, there was no significant improvement in cure rate or egg reduction rate of hookworm with fatty-food co-administration. Dual-dose albendazole is a feasible alternative for improving drug effectiveness against hookworm infection and minimising drug resistance.

Trial registration
PACTR202202738940158.
A történelemdidaktika trendjei a Nemzetközi Történelemdidaktikai Társaság (ISHD) kiadványainak tükrében
Authors: Fodor Richárd , Tóth Judit 
Published: July 2023

A 21. századra a tudás hozzáférhetőségének korlátait felváltotta az ismeretek szelekciójának nehézsége. A felhalmozott hasznos és kevésbé releváns tudás óriási mennyiségben áll rendelkezésre - téglákból épült könyvtárak helyett immár különböző szerverek online tárhelyein. Így még fontosabbá vált a kérdés, hogy melyek azok a nyílt hozzáférésű szakmai platformok, amelyek megkerülhetetlenek a diszciplína tudományos életében. A történelemdidaktika mint a múlt forrásait középpontba állító, a történelmi gondolkodás fejlesztését és magasabb rendű tanulói tevékenységek megvalósítását támogató tudományterület, elősegítheti a hatékony információszelekciós stratégiák kialakítását. Tanulmányunk célja a Nemzetközi Történelemdidaktikai Társaság kiadásában megjelenő International Journal of Research on History Didactics, History Education and History Culture című folyóirat elmúlt évtizedben (2011–2021) betöltött szakmai szerepének és trendjeinek meghatározása, a lap részletes feltérképezése, elemzése és ezen keresztül a történelemdidaktika szakmai műhelyeinek, szereplőinek, aktuális irányvonalainak, problémarendszerének felvázolása. A feltáró elemzések alapján a folyóirat fókuszában a tankönyvelemzés és a különböző tartalmi-tantervi szabályozók állnak. Az európai tudományos közösségen belül a német kutatók és történelemdidaktikai műhelyek végeznek kiemelkedő tevékenységet. A kutatás eredményei egyértelműen utalnak a történelemdidaktika fejlődésének összetett irányaira, amelyek feltehetően a közeljövő tudományos diskurzusára nemzetközi és hazai viszonylatban is hatást gyakorolnak majd, elősegítve ezzel a diszciplína megújulását.
Kekerasan terhadap Remaja serta Faktor-Faktor yang Memengaruhi pada Masa Pandemi COVID-19
Authors: Pane Irene Audrey Davalynn , Sekartini Rini 
Published: July 2023

Latar belakang. Pandemi COVID-19 telah membuat pemerintah mengeluarkan peraturan untuk tetap berada di rumah. Kegiatan Pembelajaran Jarak Jauh meningkatkan durasi aktivitas remaja di rumah dan menimbulkan faktor lain yang berkaitan dengan kejadian kekerasan. Setiap tahunnya, kekerasan terhadap remaja terus meningkat. Dengan dampak buruk yang diakibatkan oleh kekerasan, timbul kepentingan mendesak untuk melakukan penelitian mengenai kejadian kekerasan terhadap remaja dan faktor-faktor yang dapat memengaruhi.Tujuan. Penelitian ini bertujuan mendeskripsikan prevalensi kekerasan terhadap remaja di masa pandemi COVID-19 beserta faktor yang memengaruhi.Metode. Penelitian observasional menggunakan analisis deskriptif dan bivariat dengan metode desain studi potong-lintang dengan pengisian kuesioner secara daring. Dilaksanakan pada bulan oktober hingga November 2021, dengan metode total population sampling dengan kriteria inklusi setiap anak yang berusia 10-18 tahun, mampu memahami dan menguasai Bahasa Indonesia, dan berdomisili di Indonesia, dan memiliki ponsel/ gadget jenis apapun milik sendiri yang dapat dipakai untuk mengisi kuesioner. Kriteria eksklusi subjek adalah anak yang tidak memiliki gangguan kognitif serta gangguan komunikasi dan tidak bersedia berpartisipasi dalam penelitian.Hasil. Didapatkan total subjek yang diteliti yakni 106 subjek. dengan sebaran terbanyak berdasarkan usia 14-17 tahun 61,3%, jenis kelamin perempuan 66%, posisi anak terakhir 34%, dan mengikuti pembelajaran jarak jauh sebanyak 96,2%. Remaja yang taat pada protokol kesehatan 21,7% dan tidak taat 78,3%. Jenis keluarga terbanyak ialah keluarga inti 83% dan orang tua remaja yang bekerja sebanyak 91,5%. Pendidikan orang tua tertinggi adalah sarjana, ayah (47,2%) dan ibu (36,8%). Sebanyak 67,9% remaja mengalami kekerasan dengan jenis kekerasan tertinggi ialah penelantaran (50,9%). Seluruh faktor pada penelitian secara statistik tidak berhubungan bermakna.Kesimpulan. Kekerasan terhadap remaja tidak berhubungan secara statistik dengan faktor anak (usia, jenis kelamin, posisi anak, pembelajaran jarak jauh) dan faktor lingkungan (jenis keluarga, pendidikan dan pekerjaan orang tua, serta tingkat ketaatan terhadap protokol kesehatan)
Frontier spirit and the making of the Japanese pioneer
Authors: Scherer Anke 
Published: July 2023

Abstract
This article analyses the origins of the so-called frontier spirit as the main feature of the Japanese pioneers who were the grass-roots agents of Japanese expansion into Asia. It argues that this narrative traces back to the government-sponsored cultivation program in Hokkaidō, where so-called tondenhei were employed as farmer-soldiers to open up the new frontier region as Japan’s first colony. After the termination of the tondenhei program, the frontier spirit took on a life of its own. It was embraced by advocates of Japanese settler colonialism on the Asian continent as a vital element of the quintessential Japanese pioneer, capable of overcoming any hardships that might arise. Consequently, the iconic Japanese pioneer in Manchuria, who eventually fell victim to Japan’s megalomanic migration machine in Northeast China, can be seen as the reincarnation of their equally unfortunate predecessor, the tondenhei soldier.
Thermal response of double network hydrogels with varied composition
Authors: Hanyková Lenka , Krakovský Ivan , Šťastná Julie , Ivaniuzhenkov Vladislav , Labuta Jan 
Published: July 2023

Abstract
The series of double network (DN) hydrogels, based on poly(N,N′-diethylacrylamide) (PDEAAm), polyacrylamide (PAAm), or poly(2-acrylamido-2-methyl-1-propanesulfonic acid) (PAMPS) were synthesized with various mass ratios of components and their thermal response was investigated. The formation of DN structure in studied hydrogels results in significant increase in Young’s modulus. PDEAAm/PAMPS hydrogels exhibited rather high swelling ratio and consequently their temperature sensitivity was not detected. DN hydrogels PDEAAm/PAAm and PDEAAm/PDEAAm displayed thermo-responsive behavior, and the dependence of transition parameters on the feed molar concentration of acrylamide and N,N′-diethylacrylamide monomers, respectively, was determined through deswelling, NMR, and Differential scanning calorimetry (DSC) experiments. A two-state process model was employed to describe the phase transition of hydrogels. By utilizing a modified van’t Hoff equation with data from deswelling, NMR, and DSC experiments, we were able to obtain thermodynamic parameters of the transition and determine the size of the cooperative domains consisting of polymer units and water molecules.
A lexical-cognitive approach to the consequences of the coronavirus crisis for the emotions and perceptions of the Spanish population aged 65 and over
Authors: Ávila-Muñoz Antonio M. 
Published: July 2023

Abstract
The COVID-19 pandemic has devastated health systems, economies, and societies. Considered a high-risk group, the elderly have been amongst the most affected. Using word association tests, we access the perceptions held by a group of individuals aged 65 and over, pre-stratified by gender and level of education, regarding certain aspects of the situation we now face. We interpret the vocabulary provided during the tests as a network of connections. Thus, we can create the metastructure of the mental lexicon and consider it the reflection of the collective perceptions associated with five cognitive categories: pandemic, old age, society, future, and politics. For this, we use a model that allows us to construct cognitive prototypes based on the theory of fuzzy sets. Previous results warn of the emotional consequences that have affected the entire population. However, we are now also able to prove that the older generation is experiencing unprecedented feelings of loneliness and neglect due to the circumstances. This could exacerbate the worry, fear, and uncertainty imposed on this group by the new normal. Finally, we suggest concrete actions for both health workers in contact with groups of elderly individuals and the research community that generally uses attitudinal surveys.
Bayesian estimation and prediction for network meta-analysis with contrast-based approach
Authors: Noma Hisashi 
Published: July 2023

Abstract
Network meta-analysis is gaining prominence in clinical epidemiology and health technology assessments that enable comprehensive assessment of comparative effectiveness for multiple available treatments. In network meta-analysis, Bayesian methods have been one of the standard approaches for the arm-based approach and are widely applied in practical data analyses. Also, for most cases in these applications, proper noninformative priors are adopted, which does not incorporate subjective prior knowledge into the analyses, and reference Bayesian analyses are major choices. In this article, we provide generic Bayesian analysis methods for the contrast-based approach of network meta-analysis, where the generic Bayesian methods can treat proper and improper prior distributions. The proposed methods enable direct sampling from the posterior and posterior predictive distributions without formal iterative computations such as Markov chain Monte Carlo, and technical convergence checks are not required. In addition, representative noninformative priors that can be treated in the proposed framework involving the Jeffreys prior are provided. We also provide an easy-to-handle R statistical package, BANMA, to implement these Bayesian analyses via simple commands. The proposed Bayesian methods are illustrated using various noninformative priors through applications to two real network meta-analyses.
Commutators of Hardy-Littlewood operators on p-adic function spaces with variable exponents
Authors: Dung Kieu Huu , Thuy Pham Thi Kim 
Published: July 2023

Abstract
In this article, we obtain some sufficient conditions for the boundedness of commutators of

p

p

-adic Hardy-Littlewood operators with symbols in central bounded mean oscillation space and Lipschitz space on the

p

p

-adic function spaces with variable exponents such as the

p

p

-adic local central Morrey,

p

p

-adic Morrey-Herz, and

p

p

-adic local block spaces with variable exponents.
Convergence of Langevin-simulated annealing algorithms with multiplicative noise II: Total variation
Authors: Bras Pierre , Pagès Gilles 
Published: July 2023

Abstract
We study the convergence of Langevin-simulated annealing type algorithms with multiplicative noise, i.e. for

V
:

R
d

→
R

V\colon\mathbb{R}^{d}\to\mathbb{R}

a potential function to minimize, we consider the stochastic differential equation

d
⁢

Y
t

=

−

σ
⁢

σ
⊤

⁢

∇
V

⁢

(

Y
t

)

⁢
d
⁢
t

+

a
⁢

(
t
)

⁢
σ
⁢

(

Y
t

)

⁢
d
⁢

W
t

+

a
⁢

(
t
)

2

⁢
Υ
⁢

(

Y
t

)

⁢
d
⁢
t

dY_{t}=-\sigma\sigma^{\top}\nabla V(Y_{t})\,dt+a(t)\sigma(Y_{t})\,dW_{t}+a(t)^{2}\Upsilon(Y_{t})\,dt

, where

(

W
t

)

(W_{t})

is a Brownian motion,

σ
:

R
d

→

M
d

⁢

(
R
)

\sigma\colon\mathbb{R}^{d}\to\mathcal{M}_{d}(\mathbb{R})

is an adaptive (multiplicative) noise,

a
:

R
+

→

R
+

a\colon\mathbb{R}^{+}\to\mathbb{R}^{+}

is a function decreasing to 0 and where Υ is a correction term.
Allowing 𝜎 to depend on the position brings faster convergence in comparison with the classical Langevin equation

d
⁢

Y
t

=

−

∇
V

⁢

(

Y
t

)

⁢
d
⁢
t

+

σ
⁢
d
⁢

W
t

dY_{t}=-\nabla V(Y_{t})\,dt+\sigma\,dW_{t}

.
In a previous paper, we established the convergence in

L
1

L^{1}

-Wasserstein distance of

Y
t

Y_{t}

and of its associated Euler scheme

Y
¯

t

\bar{Y}_{t}

to

argmin
⁡

(
V
)

\operatorname{argmin}(V)

with the classical schedule

a
⁢

(
t
)

=

A
⁢

log

−

1
/
2

⁡

(
t
)

a(t)=A\log^{-1/2}(t)

.
In the present paper, we prove the convergence in total variation distance.
The total variation case appears more demanding to deal with and requires regularization lemmas.
Crystal structure of 4-bromo-3-nitro-1H-pyrazole-5-carboxylic acid monohydrate, C4H2N3BrO4·H2O
Authors: Radović Ana , Giester Gerald , Tomić Zoran D. , Kočović David , Jaćimović Željko K. 
Published: July 2023

Abstract
C4H2N3BrO4·H2O, monoclinic, P21/c (no. 14), a = 7.177(2) Å, b = 10.999(3) Å, c = 10.414(3) Å, β =

100.145

(
11
)

∘

$100.145{(11)}^{\circ }$

, V = 809.3(4) Å3, Z = 4,

R

g
t

${R}_{\mathrm{g}\mathrm{t}}$

(F) = 0.0379,

w

R

r
e
f

$w{R}_{\mathrm{r}\mathrm{e}\mathrm{f}}$

(F
2) = 0.0714, T = 200 K
Crystal structure of 3-(4-bromophenyl)-5-methyl-1H-pyrazole, C10H9BrN2
Authors: Kočović David , Mugoša Snežana , Shova Sergiu , Tomić Zoran D. , Jaćimović Željko K. 
Published: July 2023

Abstract
C10H9BrN2, orthorhombic, P212121 (no. 19), a = 5.9070(3) Å, b = 9.2731(7) Å, c = 17.5641(14) Å, V = 962.09(12) Å3, Z = 4, Rgt
(F) = 0.0504, wRref
(F
2) = 0.0947, T = 293(2) K.
Evaluation of oxidative stress biomarkers together with myeloperoxidase/paraoxonase-1 and myeloperoxidase/high density lipoprotein cholesterol in ST-elevation myocardial infarction
Authors: Hamamcioglu Ayse Ceylan , Kalayci Belma , Kalayci Suleyman 
Published: July 2023

Abstract

Objectives
Oxidative stress is closely associated with atherosclerosis and acute coronary syndromes. The purpose of this study was to evaluate well-known and proportional oxidative stress biomarkers in ST-Elevation Myocardial Infarction (STEMI) patients.

Methods
In this single center, prospective and cross-sectional study, 107 individuals (63 patients) were studied. Total oxidative status (TOS), total antioxidant status (TAS), oxidative stress index (OSI), ischemia modified albumin (IMA), myeloperoxidase (MPO), paraoxonase-1 (PON-1) and arylesterase (AREase) enzyme activities as well as MPO/PON-1, MPO/AREase and MPO/HDL-C ratios were studied. As short-term in-hospital prognosis biomarkers; in-hospital mortality, early systolic dysfunction and spontaneous complete revascularization were investigated.

Results
Our results indicated that TOS, OSI, IMA, MPO, MPO/PON-1 and MPO/HDL ratios were significantly higher, PON-1 and AREase were significantly lower in STEMI patients compared to the control group. However, in the regression analysis performed by adjusting the differences between the groups, only IMA was found as an independent risk factor (OR=2.711, 95 % CI=1.094–6.719, p=0.031). In terms of in-hospital short-term prognostic biomarkers, a significant relationship was found only between OSI and spontaneous complete revascularization. The OSI value was higher in the group with TIMI grade 3 flow than in the group with TIMI grade 0–2 flow (2.42 [0.81–4.49] vs. 1.63 [0.33–6.07], p=0.016).

Conclusions
In STEMI patients, both the well-known (TOS, OSI, and MPO) and proportional (MPO/PON-1 and MPO/HDL cholesterol ratios) oxidative stress markers were elevated and can be considered as having a role in the pathogenesis of STEMI.
Some versions of Chaplygin gas model in modified gravity framework and validity of generalized second law of thermodynamics
Authors: Sultana Sanjeeda , Güdekli Ertan , Chattopadhyay Surajit 
Published: July 2023

Abstract
In the work reported in this paper, we have analyzed generalized Chaplygin gas (GCG) and modified generalized Chaplygin gas (MGCG) in an interacting scenario. The equation of state parameter has been analyzed in both the cases and the stability of the models has been discerned through squared speed of sound. Stability against gravitational perturbations has been observed for both GCG and MGCG interacting with pressureless dark matter. Also, the generalized second law (GSL) of thermodynamics has been tested for different enveloping horizons and validity of GSL has been observed throughout. Furthermore, f(T) gravity has been reconstructed with GCG and MGCG and phantom behaviour has been observed through reconstructed EoS parameters. The squared speed of sound has been derived for f(T) gravity and stability of the model has been established through its positivity.
Anti-SARS-CoV-2 in vitro potential of castor oil plant (Ricinus communis) leaf extract: in-silico virtual evidence
Authors: Elkousy Rawah H. , Said Zeinab N. A. , Ali Mohamed A. , Kutkat Omnia , Abu El Wafa Salwa A. 
Published: July 2023

Abstract

Ricinus communis L. is a medicinal plant that displays valuable pharmacological properties, including antioxidant, antimicrobial, analgesic, antibacterial, antiviral and anti-inflammatory properties. This study targeted to isolate and identify some constituents of R. communis leaves using ultra-performance liquid chromatography coupled with mass spectroscopy (UPLC-MS/MS) and different chromatographic techniques. In vitro anti-MERS and anti-SARS-CoV-2 activity for different fractions and for two pure isolated compounds, lupeol (RS) and ricinine (RS1) were evaluated using a plaque reduction assay with three different mechanisms and IC50 based on their cytotoxic concentration (CC50) from an MTT assay using Vero E6 cell line. Isolated phytoconstituents and remdesivir are assessed for in-silico anti-COVID-19 activity using molecular docking tools. The methylene chloride extract showed pronounced virucidal activity against SARS-CoV-2 (IC50 = 1.76 μg/ml). It was also shown that ricinine had superior potential activity against SARS-CoV-2, (IC50 = 2.5 μg/ml). Lupeol displayed the most potency against MERS, (IC50 = 5.28 μg/ml). Ricinine appeared to be the most biologically active compound. The study showed that R. communis and its isolated compounds have potential natural virucidal activity against SARS-COV-2; however, additional exploration is necessary and study for their in vivo activity.
Centrosome linker diversity and its function in centrosome clustering and mitotic spindle formation
Authors: Theile Laura , Li Xue , Dang Hairuo , Mersch Dorothee , Anders Simon , Schiebel Elmar 
Published: July 2023

AbstractThe centrosome linker joins the two interphase centrosomes of a cell into one microtubule organizing center. Despite increasing knowledge on linker components, linker diversity in different cell types and their role in cells with supernumerary centrosomes remained unexplored. Here, we identified Ninein as a C‐Nap1‐anchored centrosome linker component that provides linker function in RPE1 cells while in HCT116 and U2OS cells, Ninein and Rootletin link centrosomes together. In interphase, overamplified centrosomes use the linker for centrosome clustering, where Rootletin gains centrosome linker function in RPE1 cells. Surprisingly, in cells with centrosome overamplification, C‐Nap1 loss prolongs metaphase through persistent activation of the spindle assembly checkpoint indicated by BUB1 and MAD1 accumulation at kinetochores. In cells lacking C‐Nap1, the reduction of microtubule nucleation at centrosomes and the delay in nuclear envelop rupture in prophase probably cause mitotic defects like multipolar spindle formation and chromosome mis‐segregation. These defects are enhanced when the kinesin HSET, which normally clusters multiple centrosomes in mitosis, is partially inhibited indicating a functional interplay between C‐Nap1 and centrosome clustering in mitosis.
Randomly incorporated genomic N6‐methyldeoxyadenosine delays zygotic transcription initiation in a cnidarian
Authors: Febrimarsa  , Gornik Sebastian G , Barreira Sofia N , Salinas‐Saavedra Miguel , Schnitzler Christine E , Baxevanis Andreas D , Frank Uri 
Published: July 2023

AbstractN6‐methyldeoxyadenosine (6mA) is a chemical alteration of DNA, observed across all realms of life. Although the functions of 6mA are well understood in bacteria and protists, its roles in animal genomes have been controversial. We show that 6mA randomly accumulates in early embryos of the cnidarian Hydractinia symbiolongicarpus, with a peak at the 16‐cell stage followed by clearance to background levels two cell cycles later, at the 64‐cell stage—the embryonic stage at which zygotic genome activation occurs in this animal. Knocking down Alkbh1, a putative initiator of animal 6mA clearance, resulted in higher levels of 6mA at the 64‐cell stage and a delay in the initiation of zygotic transcription. Our data are consistent with 6mA originating from recycled nucleotides of degraded m6A‐marked maternal RNA postfertilization. Therefore, while 6mA does not function as an epigenetic mark in Hydractinia, its random incorporation into the early embryonic genome inhibits transcription. In turn, Alkbh1 functions as a genomic 6mA “cleaner,” facilitating timely zygotic genome activation. Given the random nature of genomic 6mA accumulation and its ability to interfere with gene expression, defects in 6mA clearance may represent a hitherto unknown cause of various pathologies.