bluuebunny/crossref_metadata_2025_split huggingface dataset:
Change in management for digital subtraction angiography-identified false-positive traumatic vertebral artery injury
Authors: Yi Zixin , Vankawala Jessica , Koneru Manisha , Oliveira Renato , Santucci Joshua , Morse Charles , Ifrach Joseph , Al-Atrache Zein , Fox Nicole M. , Goldenberg-Sandau Anna , Khalife Jane , Tonetti Daniel A. , Mossop Corey M. , Shaikh Hamza A. 
Published: January 2025

Background For patients with suspected traumatic vertebral artery injury (TVAI), CT angiography (CTA) is the first-line screening modality. Digital subtraction angiography (DSA) serves as the confirmatory diagnostic imaging, and is the gold standard for cerebrovascular injury assessment, due to its higher sensitivity and specificity. Among patients with TVAI based on CTA who have undergone follow-up DSA, this study aims to investigate how diagnostic information with additional imaging affects clinical management. Methods A retrospective review was conducted over 7 years (2016–2023) at a level 1 trauma center for TVAI patients undergoing both CTA and DSA. Pre- and post-DSA approaches to TVAI management were compared and summarized using propensity-score matched analysis. Results Among the 69 patients studied, 24.6% were determined to have false-positive TVAI after DSA. The rate of change in management after DSA was significantly different across DSA+ and DSA- cohorts (p = 0.02). The likelihood of a change in management in patients with based on outcome of the DSA was significant (p = 0.03) in the propensity-matched cohort. On average, 3 (NNI = 3.2) patients would need to receive a DSA for one additional patient to undergo a change in management. Conclusion This study demonstrates that, despite initial CTA imaging suggestive of TVAI, follow-up DSA imaging negative for TVAI has a significant impact on changing clinical management, including cessation of antithrombotic agents. Thus, for TVAI patients, DSA may be considered in the diagnostic workup for select patients with positive CTA. Larger cohort analyses are needed to refine imaging algorithms and optimize clinical outcomes for TVAI patients.
Heart Transplantation Outcomes for Fontan Patients When Using Contemporary Strategies: Heart-Liver Transplantation and Ventricular Assist Device Therapy
Authors: Hogue Spencer J. , Greenberg Jason W. , Mehdizadeh-Shrifi Amir , Villa Chet R. , Chin Clifford , Lorts Angela , Opotowsky Alexander R. , Lehenbauer David G. , Morales David L. S. 
Published: January 2025

Background With an increasing number of Fontan patients surviving into adulthood, the burden of end-stage heart failure is increasing. Prior studies have reported suboptimal heart transplantation (HTx) outcomes. Therefore, the authors describe their institutional experience of HTx in patients with Fontan circulation failure, including en-bloc heart-liver transplantation (HLTx) and pretransplant systemic ventricular assist device (SVAD) therapies. Methods All consecutive Fontan-palliated patients undergoing HTx or HLTx between 2013 and 2022 at the authors’ institution were included. Pretransplant characteristics and posttransplant outcomes were recorded. Results Twenty-six transplant recipients, including 5 (19%) HLTx recipients, were identified. The majority (n = 16, 62%) of patients had a cardiac diagnosis of hypoplastic left heart syndrome. Seven (26%) patients were bridged to transplant on an SVAD; the median duration of support was 104 [IQR 39-543] days. Transplantation occurred at a median of 10.6 [IQR 6.8-15.6] years post-Fontan. Fourteen (54%) patients had ≥1 in-hospital complication and 4 (15%) patients required an in-hospital reoperation. Postdischarge reinterventions included tricuspid valve repair (n = 1, 4%) and retransplantation (n = 1, 4%). Two (8%) in-hospital mortalities [22 days (post-HLTx), 2.9 months (post-HTx] and 4 (15%) postdischarge mortalities [5.4 months, 3.1 years, 5.7 years, 7.1 years (all post-HTx)] occurred. Overall survival was excellent, with in-hospital, one-year, and five-year actuarial survival being 92%, 89%, and 80%, respectively. Conclusions The current series demonstrates that excellent posttransplant outcomes are achievable for patients with Fontan circulation failure using a comprehensive approach including SVAD and HLTx therapies. Pretransplant optimization, sometimes including SVAD implantation, and meticulous operative planning are imperative strategies for successful patient outcomes.
The Bidirectional Relationship Between Workplace Bullying and Presenteeism: A Systematic Review and Meta-Analysis
Authors: Liu Minyan , Cheng Linan , Wang Yuqiang , Zeng Qinglin , Zeng Yanli 
Published: January 2025

Background: Although previous studies suggest a link between workplace bullying and presenteeism, uncertainties persist regarding the direction, strength, and influencing factors. Understanding the potential mediators and moderators is crucial to addressing these issues in workplace settings. Objective: This study aims to clarify the bidirectional relationship between workplace bullying and presenteeism, assess the strength and direction of this association, and identify individual and work-related factors that mediate or moderate these interactions. Methods: A systematic search of nine databases (PubMed, EMBASE, Cochrane Library, Web of Science, CINAHL, PsycINFO, CNKI, WANFANG, and Chinese Biomedical) was conducted from inception through March 30, 2023, with an update on September 8, 2024. Independent reviewers screened the literature, extracted data, and evaluated methodological quality using the Risk Of Bias In Non-randomized Studies of Exposure tool. Odds ratios, relative risks, and 95% confidence intervals were calculated to assess effect sizes. Results: After adjusting for confounders, workers exposed to workplace bullying had 1.74 times higher odds of reporting presenteeism compared to non-exposed individuals (95% CI [1.02, 2.46]). Workers reporting presenteeism also had increased odds of later workplace bullying exposure ( OR = 2.29, 95% CI [1.23, 3.36]). Various individual and work-related factors were identified as potential mediators and moderators influencing these associations. Conclusion: This study establishes a bidirectional relationship between workplace bullying and presenteeism. Both individual and work-related factors play a critical role as mediators and moderators, potentially mitigating or amplifying the workplace bullying-presenteeism cycle. Future interventions should target these factors to disrupt this harmful dynamic and improve employee well-being.
Developing a Standard Tool for Measuring Health Literacy Related to Transfusion-Transmitted Infections
Authors: Manzouri Leila , Masoudifar Saman , Roustaei Narges , Rad Fariba 
Published: January 2025

Background Transfusion-transmitted infections (TTI) are among the most critical challenges of blood transfusion. Patients with lower health literacy can have adverse consequences for blood transfusion and due to the lack of standard tools for measuring health literacy related to TTI, this study was conducted to develop a standardized tool for assessing Health literacy associated with TTI. Aim This study aimed to develop a standardized tool for assessing Health literacy related to TTI. Material and Methods This study was a cross-sectional analytical study of the tool development and validation type, according to the definitions provided for health literacy, questions were designed in the five areas of search, understanding, evaluation, decision-making, and application. The questionnaire was provided to relevant experts to evaluate the content validity with a qualitative and quantitative approach. After making corrections according to the experts’ opinions, the Content Validity Index (CVI) and the Content Validity Ratio (CVR) were checked. It was given to people who were at least literate in reading and writing levels to check the quantitative and qualitative face validity. Finally, the structural validity of the tool was checked by performing a confirmatory factor analysis and its reliability by calculating Cronbach's Alpha. Results The CVR and CVI had an average of 0.86 and 0.93 respectively. The reliability of the questionnaire was calculated using Cronbach's alpha coefficient of 0.744. In examining the structural validity of the tool, the root mean squared error (RMSE) index was less than 0.0001, the Goodness of Fit Index (GFI) was 0.975, the Adjusted Goodness of Fit Index (AGFI) was 0.957, Bentler and Bonnet's Normed Fit Index (NFI) was 1 and Comparative Fit Index (CFI) was 0.856. Conclusion The tool developed is reliable and valid, and can be used to measure the level of health literacy related to transfusion-transmitted infections.
Exploring Peripartum Cannabis Use Among Young Sexual Minority People: A Qualitative Study
Authors: Boss Nicole , Frankeberger Jessica , Hossain Fahmida , Mark Elyse , Coulter Robert W. S. , De Genna Natacha M. 
Published: January 2025

Introduction: Young childbearing sexual minority (SM) people are more likely to use cannabis and to have an unintended pregnancy than their heterosexual peers; however, little is known about their perceptions and experiences of peripartum cannabis use. This qualitative study explores the relationships young pregnant and parenting SM people have with cannabis, as well as their feelings and opinions about prenatal cannabis use. Method: Participants who identified as SM from baseline surveys of the YoungMoms study were recruited for semi-structured qualitative interviews (n = 13). Interviews focused on cannabis use experiences before and during pregnancy. Data were analyzed using thematic analysis. Results: Data analysis revealed 3 key themes. Participants described the contextual adaptivity of their cannabis use, discussing how their use changed based on social context, mental health, and stress but was not directly related to their sexuality. Pregnancy was identified as a potential turning point for cannabis use as participants described trying to reduce or abstain during pregnancy, although some struggled to do so or continued use to address pregnancy symptoms. Facilitating factors of prenatal cannabis reduction were described, including focusing on the financial toll, social environment changes, access to health-related guidance, and replacement hobbies. Conclusions: This study provides novel information about a public health concern among a pregnant population that is often overlooked in prenatal substance use research. Similar to their heterosexual peers, pregnancy may serve as an opportune time for intervention among young SM people who use cannabis, but consideration of unique factors that contribute to their cannabis use is needed.
Timing of risk factors, prodromal features, and comorbidities of dementia from a large health claims case–control study
Authors: Teipel Stefan , Akmatov Manas , Michalowsky Bernhard , Riedel-Heller Steffi , Bohlken Jens , Holstiege Jakob 
Published: January 2025

Abstract

Background
Many risk factors for dementia have been identified, but the timing of risk is less well understood. Here, we analyzed risk factors in a case–control study covering 10 years before an incident dementia diagnosis.

Methods
We designed a case–control study using insurance claims of outpatient consultations of patients with German statutory health insurance between January 1, 2012, and December 31, 2022. We included patients with an incident diagnosis of dementia and controls without a diagnosis of dementia matched 1:2 for age, sex, region, and earliest year of outpatient encounter. We selected exposures based on previous systematic reviews, case–control and cohort studies reporting on risk factors, comorbidities, and prodromal features of dementia. We calculated the prevalence of risk factors in cases and controls and odds ratios for each year before the index date, along with Bonferroni-corrected confidence intervals, using conditional logistic regression.

Results
We identified a total of 1,686,759 patients with incident dementia (mean (SD) age, 82.15 (6.90) years; 61.70% female) and 3,373,518 matched controls (mean (SD) age, 82.15 (6.90) years; 61.70% female). Study participants were followed up for a mean (SD) of 6.6 (2.3) years. Of the 63 risk factors and prodromal features examined, 56 were associated with an increased risk of dementia in all years during the 10th and the 1st year before the index date. These included established risk factors, such as depression, hypertension, hearing impairment, nicotine and alcohol abuse, obesity, hypercholesterolaemia, traumatic brain injury, and diabetes. The greatest risk, with odds ratios greater than 2.5, was conferred by delirium, memory impairment, mental retardation, personality and behavioral disorders, sensory disorders, schizophrenia, and psychosis. Cancer was associated with a reduced risk of dementia.

Conclusions
This large case–control study confirmed established risk factors of dementia. In addition, the study identified non-specific diagnoses that showed a steep increase in risk close to the index date, such as psychosis, conduct disorder, and other sensory disorders. Consideration of these diagnoses, which may represent prodromal features rather than risk factors for dementia, may help to identify people with dementia in routine care.
Critically ill adult patients with acute leukemia: a systematic review and meta-analysis
Authors: Chean Dara , Luque-Paz David , Poole Daniele , Fodil Sofiane , Lengliné Etienne , Dupont Thibault , Kouatchet Achille , Darmon Michael , Azoulay Élie 
Published: January 2025

Abstract

Background
To describe the use of life-sustaining therapies and mortality in patients with acute leukemia admitted to the intensive care unit (ICU).

Methods
The PubMed database was searched from January 1st, 2000 to July 1st, 2023. All studies including adult critically ill patients with acute leukemia were included. Two reviewers independently selected the studies, assessed bias using the Newcastle-Ottawa scale for cohort studies, and performed data extraction from full-text reading. We performed a proportional meta-analysis using a random effects model. The primary outcome was all-cause ICU mortality. Secondary outcomes included reasons for ICU admission, use of organ support therapies (mechanical ventilation, vasopressors and renal replacement therapy), hospital, day-90 and one-year mortality rates.

Results
Of the 1,331 studies screened, 136 (24,861 patients) met the inclusion criteria and were included in the meta-analysis. Acute myeloid leukemia affected 16,269 (66%) patients, acute lymphoblastic leukemia affected 835 (3%) patients, and the type of leukemia was not specified in 7,757 (31%) patients. Acute respiratory failure (70%) and acute circulatory failure (25%) were the main reasons for ICU admission. Invasive mechanical ventilation, vasopressors and renal replacement therapy, were needed in 65%, 53%, and 23% of the patients, respectively. ICU mortality was available in 51 studies (6,668 patients, of whom 2,956 died throughout their ICU stay), resulting in a metanalytical proportion of 52% (95% CI [47%; 57%]; I
2 93%). In a meta-regression, variables that influenced ICU mortality included year of publication, and intubation rate.

Conclusion
Acute respiratory failure is the main reason for ICU admission in patients with acute leukemia. Mechanical ventilation is the first life-sustaining therapy to be used, and also a strong predictor of mortality.

Trial registration
This study’s protocol was preregistered on PROSPERO (CRD42023439630).
Gut microbial dysbiosis, IgA, and Enterococcus in common variable immunodeficiency with immune dysregulation
Authors: Berbers Roos-Marijn , Paganelli Fernanda L. , van Montfrans Joris M. , Ellerbroek Pauline M. , Viveen Marco C. , Rogers Malbert R. C. , Salomons Moniek , Schuurmans Jaap , van Stigt Thans Martine , Vanmaris Remi M. M. , Brosens Lodewijk A. A. , van der Wal Maria Marlot , Dalm Virgil A. S. H. , van Hagen P. Martin , van de Ven Annick A. J. M. , Uh Hae-Won , van Wijk Femke , Willems Rob J. L. , Leavis Helen L. 
Published: January 2025

Abstract

Background
Common variable immunodeficiency (CVID) is characterized by hypogammaglobulinemia and recurrent infections. Significant morbidity and mortality are caused by immune dysregulation complications (CVIDid), which affect around one-third of CVID patients and have a poorly understood etiology. Here, we investigate the hypothesis that gut microbial dysbiosis contributes to the inflammation underlying CVIDid.

Results
Bacterial invasion of colonic crypts was observed in CVID (3/15) and X-linked agammaglobulinemia (XLA, 1/3), but not in healthy control (HC, 0/9) biopsies. Fecal gut microbiota was characterized using 16S rRNA-targeted amplicon sequencing. Increased bacterial load, decreased alpha diversity and distinct beta diversity were observed in CVIDid (n = 42) compared to HC (n = 48), and similar results were seen in CVID with IgA deficiency (n = 40) compared to HC. CVIDid and CVID-IgA showed enrichment of the genus Enterococcus, and in vitro studies confirmed the inflammatory potential of Enterococcus gallinarum and Enterococcus hirae in patient monocytes.

Conclusions
This study further supports the hypothesis that a dysregulated gut microbiota, with IgA deficiency as an important driving factor, contributes to systemic inflammation in primary antibody deficiency, and introduces enterococci as potential pathobionts in CVIDid.
Understanding the optical theorem of scattering: Scattering surface area against scattering cross-section, an example with ellipsoidal scattering
Authors: Li Youning 
Published: January 2025

Abstract
In this paper, we propose using the scattering surface area rather than the scattering cross-section to characterize the scattering behavior of ellipsoidal rigid bodies. We examined the scattering behavior of ellipsoidal rigid bodies, focusing on the relationship between their surface area and total scattering cross-section. Building on the foundational work of Carson Flammer, we utilize the spheroidal coordinate system to derive solutions for both prolate and oblate spheroids. Our analysis reveals that under the long-wavelength approximation, the total scattering cross-section is equivalent to the surface area of the ellipsoid, a relationship that holds true for both small and moderate eccentricities. This finding extends the established optical theorem, previously validated for spherical bodies, to more complex geometries.
Self-similar scaling of higher-order interactions in complex networks
Authors: Wu Minze , Weng Tongfeng , Ren Zhuoming , Chen Xiaolu , Li Chunzi 
Published: January 2025

Abstract
Self-similarity of complex networks has been exhaustively explored but only concentrating on pairwise interactions between nodes. We restudy self-similar characteristics of networks from algebraic topological perspective. By virtue of a box covering technique, we generate consecutive renormalized networks with respect to different length scales. Interestingly, we find that the number of a specific order of clique in the renormalized networks presents a clearly scaling behavior. Moreover, we show that the growth pattern of cliques is likely to follow a universal principle for seemingly different kinds of real networks. Our work, for the first time, reveals the role of higher-order interactions in shaping self-similarity of complex networks.
Multidimensional Sleep Health, Glycemic Control, and Self-reported Outcomes in Type 1 Diabetes: A Cross-sectional Study
Authors: Abu Irsheed Ghada , Steffen Alana , Martyn-Nemeth Pamela , Park Minsun , Quinn Laurie , Duffecy Jennifer , Baron Kelly Glazer , Saleh Adam Hussain , Takgbajouah Mary , Bimbi Olivia , Kessler Justine , Mihailescu Dan , Reutrakul Sirimon 
Published: January 2025

Abstract

Context
Sleep health is multidimensional. While studies have shown associations between certain sleep dimensions and health in type 1 diabetes (T1D), global sleep health has rarely been considered.

Objective
To examine the associations between individual sleep dimensions and multidimensional sleep health (MSH) on glycemic control and self-reported outcomes in T1D.

Methods
Data from 116 adults with T1D participating in a sleep study (NCT04506151) were analyzed. Sleep satisfaction and alertness were assessed by questionnaires. Sleep timing, efficiency, duration, and regularity were derived from 7-day actigraphy. A composite MSH score was created by counting “healthy sleep” across these 6 measures. Glycemic control was assessed by 7-day continuous glucose monitoring and hemoglobin A1C (A1C). Self-reported outcomes were collected through questionnaires.

Results
After adjusting for covariates, greater sleep irregularity was associated with higher glycemic variability (b = 5.048, P &lt; .01), less time in range (TIR) (b = −10.806, P &lt; .01), higher time above range (TAR) (b = 7.40, P &lt; .05), and higher A1C (b = .365, P &lt; .05)]. Poor sleep satisfaction was associated with higher diabetes distress and depression (b = .29, P &lt; .05, b = 3.59, P &lt; .05), respectively. Later sleep timing was associated with higher depression (b = 1.545, P &lt; .05), while lower sleep efficiency was associated with higher depression (b = 1.545, P &lt; .01). Worse MSH was significantly associated with lower TIR (b = 2.376, P &lt; .05), higher TAR, higher A1C, and depression (b = −2.38, P &lt; .05; b = −.177, P &lt; .01; b = −1.275, P &lt; .05, respectively).

Conclusion
Sleep irregularity likely drives the association between MSH and glycemic control, while poor sleep satisfaction, lower efficiency, and later timing contribute to the association between MSH and depression. These results highlight the importance of comprehensive sleep health evaluation in T1D.
Amino Acids and CART Distinguish A−β+ Ketosis-Prone Diabetes From Type 1 and Type 2 Diabetes During Hyperglycemic Crises
Authors: Jahoor Farook , Hsu Jean W , Keene Kelly R , Peacock W Frank , Huang Xiaofang , Guffey Danielle , Byun Jinyoung , Bennet Rasmus , Lernmark Ake , Tosur Mustafa , Balasubramanyam Ashok 
Published: January 2025

Abstract

Context
When clinically stable, patients with A−β+ ketosis-prone diabetes (KPD) manifest unique markers of amino acid metabolism. Biomarkers differentiating KPD from type 1 (T1D) and type 2 diabetes (T2D) during hyperglycemic crises would accelerate diagnosis and management.

Objective
Compare serum metabolomics of KPD, T1D, and T2D patients during hyperglycemic crises, and utilize classification and regression tree (CART) modeling to distinguish these forms of diabetes.

Methods
At an urban hospital emergency center, adults with KPD, T1D, and T2D during hyperglycemic crises with or without diabetic ketoacidosis (DKA), and healthy controls, underwent comparisons of serum metabolite and hormonal profiles and CART analyses. Group differences in concentrations of amino acids, their metabolites, and relationship to glucose counterregulatory hormones were determined, as well as C-peptide cutoffs and analytes to distinguish KPD, T1D, and T2D.

Results
Concentrations of most amino acids were similar in KPD and T1D and lower compared to T2D (P &lt; .05). Glucagon and cortisol concentrations were correlated with 3-methylhistidine and blood urea nitrogen in KPD but not in T1D. A C-peptide cutoff of 0.496 ng/mL differentiated T1D from KPD during DKA. CART revealed that a regression model based on the concentrations of β-hydroxybutyrate, C-peptide, glucagon, alpha-keto-β-methylvalerate, cystine, and myristoyl-L-carnitine distinguished KPD from T1D and T2D.

Conclusion
During DKA, KPD and T1D patients have similarly altered amino acid profiles that differentiate them from T2D patients. Elevated protein catabolic hormones drive altered amino acid metabolism in KPD, rather than insulin deficiency as with T1D. A combination of 6 analytes differentiates KPD from T1D and T2D during hyperglycemic crises.