bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hypoxia signaling in cancer: Implications for therapeutic interventions
Authors: Zhuang Yan , Liu Kua , He Qinyu , Gu Xiaosong , Jiang Chunping , Wu Junhua 
Published: January 2023

AbstractHypoxia is a persistent physiological feature of many different solid tumors and a key driver of malignancy, and in recent years, it has been recognized as an important target for cancer therapy. Hypoxia occurs in the majority of solid tumors due to a poor vascular oxygen supply that is not sufficient to meet the needs of rapidly proliferating cancer cells. A hypoxic tumor microenvironment (TME) can reduce the effectiveness of other tumor therapies, such as radiotherapy, chemotherapy, and immunotherapy. In this review, we discuss the critical role of hypoxia in tumor development, including tumor metabolism, tumor immunity, and tumor angiogenesis. The treatment methods for hypoxic TME are summarized, including hypoxia‐targeted therapy and improving oxygenation by alleviating tumor hypoxia itself. Hyperoxia therapy can be used to improve tissue oxygen partial pressure and relieve tumor hypoxia. We focus on the underlying mechanisms of hyperoxia and their impact on current cancer therapies and discuss the prospects of hyperoxia therapy in cancer treatment.
Exploring personalised care planning approaches for adults with long‐term conditions to inform future musculoskeletal care planning: A mixed‐methods systematic scoping review protocol
Authors: Walsh Jacinta , Hill Jonathan 
Published: January 2023

AbstractIntroductionThis systematic scoping review protocol outlines current research into care planning processes and highlights the need to synthesise the knowledge base available since the latest Cochrane review. Review results will underpin the formation of a future intervention designed to successfully optimise care planning consultations for musculoskeletal (MSK) physiotherapists, supporting shared decision‐making processes and consequently influencing health care practices for the betterment of patient care.AimTo systematically gather and synthesise the existing knowledge base surrounding personalised care planning approaches for long term conditions which may be informative for MSK care planning in the future.Objectives1. Following the Cochrane review in 2015, to synthesise new evidence available to inform personalised care planning interventions for patients with long‐term conditions. 2. Of the identified studies providing strong evidence, to determine what high‐quality training resources are available to support clinicians in delivering personalised care planning interventions.PIO FrameworkPopulation– Adults with long‐term health conditions. Intervention – Personalised care planning.Outcome– Any subjective or objective heath improvement.Databases1. Cochrane Central Register of Controlled Trials (CENTRAL). 2. MEDLINE & MEDLINE In‐process (Ovid). 3. EMBASE (Ovid). 4. PsycINFO (Ovid). 5. Trial registers (clinicaltrials.gov). 6. WHO International Clinical Trials Registry Platform.DisseminationSocial media platforms including Twitter, Instagram, YouTube and Facebook will be used to maximise the viewership of the protocol. An abstract of the review will be submitted to present at relevant conferences. The review findings will also be presented to MSK stakeholders interested in MSK care planning approaches.
Evaluating an intervention of telehealth education and simulation for advanced practice registered nurse students: A single group comparison study
Authors: Jones Heather M. , Ammerman Beth A. , Joiner Kevin L. , Lee Deborah R. , Bigelow April , Kuzma Elizabeth K. 
Published: January 2023

AbstractAs healthcare delivery continues to evolve and expand, nurse educators must prepare advanced practice registered nursing (APRN) students to use telehealth technology safely, effectively, and confidently. The aims of this study were to describe APRN students' beliefs and confidence regarding the delivery of care via telehealth in their future practice. To evaluate these aims, a single group comparison study was conducted. APRN students received an intervention comprised of multimodal telehealth instruction, which involved the simulated application of telehealth with standardized patients. Students' beliefs regarding telehealth did not significantly change between the pre‐ and post‐intervention, in which all areas were rated high pre‐intervention. Students reported an increase in their perception and confidence post‐intervention. Integration of telehealth into the APRN curriculum is essential to instil knowledge and confidence as healthcare technology advances.
Predictor role of marital conflict on maternal competency with mediating role of perceived stress and concerns during pregnancy: A structural equation model
Authors: Alipour Sepideh Mohammad , Rahimzadeh Mitra , Tourzani Zahra Mehdizadeh , Mahmoodi Zohreh , Esmaelzadeh Saeieh Sara 
Published: January 2023

AbstractAimPregnancy prepares the mother for the transition to motherhood. Maternal concerns during pregnancy cause reduced time spent with the spouse and lack of social support; additional stresses such as marital conflicts could impact maternal competency. This study aimed to assess the predictive effect of marital conflicts with the mediating role of perceived stress and pregnancy concern on maternal competency.MethodsThis was a longitudinal study. It was done on 250 mothers referred to selected health centers in Alborz province. The sampling method was convenient. Marital conflicts, perceived stress, and pregnancy concerns questionnaires were completed in the third trimester of pregnancy, and the maternal competency questionnaire was completed 6 weeks after delivery. Data were analyzed by SPSS software and smart partial least squares.ResultsThe results of structural equations showed that marital conflicts have a negative and significant effect on maternal competency (β = −0.14), marital conflicts have a positive and significant effect on perceived stress (β = 0.42), and marital conflicts have a positive and significant effect on pregnancy concern (β = 0.31). Also, perceived stress negatively and significantly affected maternal competency (β = −0.36).DiscussionResults of the study showed the necessities for screening and identifying mothers with conflicts and assessing the perceived stress of mothers will improve the mental health of pregnant mothers and consequently increase maternal competency.
Current Management of Subcondylar Fractures: A Systematic Review
Authors: Shikara Meryam , Bridgham Kelly , Ludeman Emilie , Vakharia Kalpesh , Justicz Natalie 
Published: January 2023

AbstractObjectiveThe aim of this study is to review the current literature on treatment of subcondylar fractures using traditional open reduction internal fixation (ORIF), closed reduction with maxillomandibular fixation (MMF), and endoscopic open approaches.Data SourcesPubMed, Embase, Cochrane CENTRAL,Clinicaltrials.gov, and WHO ICTRP.Review MethodsA comprehensive database search was performed in accordance with PRISMA guidelines. All English‐only texts published in the last 20 years with ≥10 patients were included. Studies that included patients <16 years old were excluded.ResultsThirty‐two studies met the final inclusion criteria. Nine studies compared ORIF with closed reduction using MMF, 12 studies evaluated ORIF via different approaches, and 10 studies evaluated outcomes after endoscopic approaches. Five studies reported significant improvement in mouth opening with ORIF compared to closed reduction. In 1 study that recorded patient‐reported outcomes measure (FACE‐Q scale), quality of life scores and patient satisfaction were significantly higher in the ORIF group. Among the 10 studies that used the endoscopic approach, transient facial nerve injury ranged from 0% to 10%.ConclusionSeveral studies report better mouth opening, dental occlusion, and functional outcomes after ORIF compared to closed reduction, while some found no significant difference. Endoscopic approaches provide ease of access to the condyle with a low incidence of facial nerve injury. However, limitations include special equipment, longer operative times, and a steep learning curve using an endoscope. This review provides surgeons with an overview of the current literature on subcondylar fractures to allow for an individualized management approach for each patient.
Sociodemographic Factors Affecting Loss to Follow‐Up After Newborn Hearing Screening: A Systematic Review and Meta‐analysis
Authors: Atherton Kelly M. , Poupore Nicolas S. , Clemmens Clarice S. , Nietert Paul J. , Pecha Phayvanh P. 
Published: January 2023

AbstractObjectiveUniversal newborn hearing screening (NBHS) has been widely implemented as a part of early hearing detection and intervention (EHDI) programs worldwide. Even with excellent provider knowledge and screening rates, many infants do not receive definitive hearing testing or intervention after initial screening. The objective of this study was to identify sociodemographic factors contributing to loss of follow‐up.Data SourcesPubMed, Scopus, and CINAHL.Review MethodsPer Preferred Reporting Items for Systematic Reviews and Meta‐Analyses guidelines, the databases were searched from the date of inception through December 28, 2021. Studies containing sociodemographic information on patients who were referred to NBHS were included. Meta‐analysis of odds ratios (ORs) was performed comparing rates of sociodemographic variables between patients adherent and nonadherent to follow‐up.ResultsA total of 169,238 infants from 19 studies were included. Low birth weight (OR 1.6 [95% confidence interval, CI 1.2‐2.2, p < .001), racial minority (OR 1.4 [95% CI 1.2‐1.6], p < .001), rural residence (OR 1.5 [95% CI 1.1‐1.9], p = .005), lack of insurance (OR 1 [95% CI 1.4‐2.5], p < .001), and public or state insurance (OR 1.7 [95% CI 1.2‐4.2], p = .008) were associated with missed follow‐up after referred NBHS. Associated maternal factors included low maternal education (OR 1.8 [95% CI 1.6‐2.0], p < .001), young maternal age (OR 1.5 [95% CI 1.5‐1.6], p < .001), unmarried maternal status (OR 1.5 [95% CI 1.1‐1.9], p = .003), and current or former maternal smoking status (OR 1.8 [95% CI 1.4‐2.2], p < .001).ConclusionBoth infant and maternal sociodemographic factors influence follow‐up compliance after referred NBHS. Focused efforts should be made by medical providers and policymakers to address these factors to ensure appropriate newborn hearing care and interventions are achieved.
HS‐SPME coupled with GC–MS for elucidating differences between the volatile components in wild and cultivated Atractylodes chinensis
Authors: Lei Hui , Yue Jiao , Yin Xin‐yu , Fan Wei , Tan Song‐hui , Qin Li , Zhao Yi‐nian , Bai Jian‐hua 
Published: January 2023

AbstractIntroductionAtractylodes chinensis is a Chinese herb that is used in traditional medicine; it contains volatile components that have enormous potential for pharmaceutical, food, and cosmetic applications. The destruction of wild resources demands significant improvement in the quality of artificial cultivation of Atractylodes chinensis. However, little is known about the compositional differences in the volatile substances derived from the wild and cultivated varieties of Atractylodes chinensis.ObjectivesWe aimed to evaluate the specific components of Atractylodes chinensis and analyse the similarities and differences between the volatile components and metabolic pathways in the wild and cultivated varieties.Material and methodsMetabolomic analysis using gas chromatography–mass spectrometry (GC–MS) was employed following the extraction of volatile components from Atractylodes chinensis using headspace solid‐phase microextraction (HS‐SPME).ResultsA total of 167 volatile metabolites were extracted, and 137 substances were matched with NIST and Wiley databases. Among them, 76 compounds exhibited significant differences between the two sources; these mainly included terpenes, aromatics, and esters. KEGG enrichment analysis indicated that the differential metabolites were primarily involved in the biosynthesis of secondary metabolites, terpene biosynthesis, and limonene and pinene degradation; all these pathways have geranyl diphosphate (GDP) as the common link.ConclusionThe total content of volatile substances extracted from wild Atractylodes chinensis was 2.5 times higher than that from the cultured variety; however, each source had different dominant metabolites. This study underscores the necessity for protecting wild Atractylodes chinensis resources, while enhancing the quality of cultivated Atractylodes chinensis.
Structural relationship among academic motivation, academic self‐efficacy, problem solving skills, creative thinking skills, and critical thinking skills
Authors: Orakci Şenol 
Published: January 2023

AbstractThis study investigates the structural relationship among academic motivation, academic self‐efficacy (ASE), problem solving skills (PSS), creative thinking skills (CRTS), and critical thinking skills (CTS). Structural Equation Model was utilized to compute the relationships between these variables. The sample of the study was comprised of 575 student teachers studying in Faculties of Education in Turkey in the academic year 2021–2022. The findings underline that academic motivation had a significant direct effect on CRTS and self‐efficacy had a significant direct effect on CRTS. In addition, the present study revealed that PSS had a significant direct effect on both creative thinking and CTS as well as revealing that creative thinking had a significant direct effect on CTS. Finally, in the present study, creative thinking significantly partially mediated the relationships between academic motivation, ASE, PSS, and CTS. These findings suggest implications for teacher training within the context of raising qualified teachers because the quality in the learning‐teaching process is positively expected to be influenced by the variables explored in the current study.
Initiation of distress screening in oral cancer clinics in Sri Lanka
Authors: Ratnasekera Nadisha , Perera Irosha , Kandapola Arachchige Pushpakumara , Jayasekara Prasanna 
Published: January 2023

AbstractObjectiveThis paper describes the initiation of distress screening in oral cancer clinics, among patients with oral cancer in Sri Lanka, addressing the service gap of lack of psychosocial oncology services. This involved validation of the Sinhala version of the Distress Thermometer (DT) and Problem List (PL) as an adjustment disorder (AD) screening tool.MethodsThe DT and PL were translated into the Sinhala language and cross‐culturally adopted by the “modified Delphi” technique. The judgment validity was obtained through face, content, and consensual validation. The criterion validation of DT was performed among 95 oral cancer patients from two oro‐maxillofacial‐oncological hospitals in Sri Lanka, against the AD diagnosis of two consultant psychiatrists.ResultsThe DT and the PL revealed good judgment validity. The optimal cut‐off point of DT was 4 with a sensitivity of 91.8% (95% CI = 80.8%–96.8%), specificity of 78.3% (95% CI = 64.4%–87.7%), positive predictive value of 0.81 (95% CI = 0.53%–1.1%) and negative predictive value of 0.90 (95% CI = 0.2%–1.7%). The test re‐test reliability of DT was excellent (Kappa coefficient 0.894). The area under the curve was 0.843. The PL demonstrated poor internal consistency in practical problems (KD‐20 = 0.4), social problems (KD‐20 = 0.3) and spiritual problems (KD‐20 = 0.6).ConclusionsThe Sinhala version of DT and PL were deemed a valid AD screening tool for patients with oral cancer in Sri Lanka to initiate distress screening in busy oral cancer clinics. However, further validation for the full spectrum of distress is needed, preferably with improvements to PL.
Unmanned aerial system‐based high‐throughput phenotyping for plant breeding
Authors: Bhandari Mahendra , Chang Anjin , Jung Jinha , Ibrahim Amir M. H. , Rudd Jackie C. , Baker Shannon , Landivar Jose , Liu Shuyu , Landivar Juan 
Published: January 2023

AbstractUnmanned aerial systems (UASs) have increased our capacity for collecting finer spatiotemporal resolution data that were previously unobtainable through conventional methods. The use of UAS for obtaining high‐throughput phenotyping (HTP) data in plant breeding programs has gained popularity in recent years. The integrity and quality of the raw data are essential for ensuring the accuracy of predictive tools and proper interpretation of the data. This paper summarizes the standard operation procedures for high‐quality UAS data collection, processing, and analysis for UAS‐based HTP (UAS‐HTP). Plant breeders can follow these procedures to implement a UAS‐HTP system in their germplasm enhancement and cultivar development programs.
Creep behaviors of HTPE propellants
Authors: Zhu Guocui , Liu Shuang , Liu Wenhao , Zheng Mengze , Luo Yunjun 
Published: January 2023

AbstractIn this paper, creep tests were carried out on HTPE/AP/Al/RDX propellant specimens to investigate the effects of stress level and temperature on their creep behavior and to investigate the creep mechanism. Higher stresses and temperature can cause greater creep strain in the propellant, ultimately leading to its destruction. On this basis, the creep master curve was further obtained based on the Time‐Temperature Superposition Principle (TTSP), extending the creep investigation time range to 1010 s. Based on previous experience, some explorations have been made on constitutive equations. The burgers model fits the creep behavior under different conditions more closely, while the Norton model has higher stress sensitivity.
A comparison between the da Vinci Xi EndoWrist Stapler and a conventional laparoscopic stapler in rectal transection: A randomized controlled trial
Authors: Teo Nan Zun , Ngu James Chi‐Yong 
Published: January 2023

AbstractBackgroundDistal rectal transection following robotic total mesorectal excision for rectal cancer is challenging. This can be performed with either a robotic stapler (RS) or laparoscopic stapler (LS). We compared the operative outcomes and ergonomic differences between RS and LS.MethodsForty patients with rectal cancer who were planned for robotic rectal surgery were randomized to either RS or LS.ResultsThe mean number of stapler cartridges expended was similar between RS and LS (1.75 vs. 2.05, p = 0.082). Significantly less stapler adjustments were required in the RS group (1.55 vs. 2.75, p = 0.014). Results from the user experience survey showed that RS scored better.ConclusionThe RS required less adjustments and resulted in a better user experience. While this complemented the use of robotics in rectal surgery, it did not result in a significant reduction in the number of stapler cartridges required for rectal transection.
A systematic literature review of flying ad hoc networks: State‐of‐the‐art, challenges, and perspectives
Authors: Pasandideh Faezeh , Costa João Paulo J. da , Kunst Rafael , Hardjawana Wibowo , de Freitas Edison Pignaton 
Published: January 2023

AbstractUnmanned aerial vehicles (UAVs), also known as drones, communicate, collaborate, and form flying ad hoc networks (FANETs) to perform many different missions, ranging from delivery tasks to agriculture applications. Recently, FANETs have been integrated with different technologies, such as artificial intelligence (AI), virtual reality, and Internet of Things. Such new avenues for the use of UAVs directly impact the research on FANETs and cause some major challenges, such as security and physical layer issues, resource management, and UAV positioning issues that need to be addressed. Several researchers have been working for the last few years to propose AI and machine learning (ML)‐based solutions for different use cases in UAV‐based networks. They present the limitations of the existing research work and highlight some possible future works on FANETs. However, exhibiting the trends in the UAV research papers in a quantitative manner is still required to motivate researchers to rethink the research on FANETs. Therefore, this study covers more than 170 scientific publications extracted from five trusted academic databases published from 2013 to 2021 to provide a thorough overview of the main research and development statistics in the area of FANETs, the open challenges existing in this area and the ML‐based solutions to solve these challenges. In addition, the investigation of emerging technologies integrated with FANETs, as well as the simulation tools employed for evaluating FANETs' performance are discussed. Moreover, the future research directions in the area of FANETs are considered within a prospective vision discussion.
TiO2 Decorated SiO2 Nanoparticles as Efficient Antibacterial Materials: Enhanced Activity under Low Power UV Light
Authors: Mahanta Urbashi , Deshpande Atul S. , Khandelwal Mudrika 
Published: January 2023

AbstractTiO2 based photocatalytic materials show effective antibacterial activity typically under a high‐power UV light. However, exposure to high‐intensity radiation may be detrimental to biological as well as non‐biological materials. In this work, we demonstrate a significantly higher antibacterial activity at even low power UV where TiO2 nanoparticles are decorated on silica nanoparticles. The antibacterial activity of the nanoparticles with varying Si : Ti molar compositions were explored against E. coli to obtain effective antibacterial activity with minimal power of UV radiation (8 W). The nanoparticles with a molar ratio of SiO2 : TiO2=2 : 1 (Si2Ti) showed the best antibacterial activity. The minimum inhibitory concentration (MIC) of the Si2Ti catalyst was also determined for varying duration of exposure to 8 W UV radiation. Even at a very low concentration of 5 mg/mL Si2Ti sample, where the active catalyst amount was only 1.66 mg/mL, 100 % killing of E. coli was observed after 90 minutes of UV exposure. For the exposure time of 120 minutes, MIC was reduced even further to 3 mg/mL with an active catalyst amount of 1 mg/mL. The excellent antibacterial activity is attributed to the small crystallite size of TiO2 along with enhanced interaction with bacteria owing to the presence of SiO2. In addition, Si2Ti showed good biocompatibility with more than 87 % cell viability with fibroblast cells for 500 μg/mL of the sample.
Facile Multicomponent Mannich Reaction towards Biologically Active Compounds
Authors: Borah Preetismita , Borah Gongutri , Nath Arabinda C. , Latif Wajid , Banik Bimal Krishna 
Published: January 2023

AbstractThe Mannich reaction is one of the most broadly used organic reactions for constructing C−N and C−C bonds in synthetic chemistry. This review focuses on the multicomponent Mannich reaction and its variants for the synthesis of biologically active moieties such as anticancer, antimicrobial, antimalarial, antitubercular, anti‐inflammatory and anticonvulsant molecules. A few organocatalyzed asymmetric Mannich reactions are also incorporated.