bluuebunny/crossref_metadata_2025_split huggingface dataset:
Stakeholders' perception of mandatory CSR in the Indian hotel industry: scale development and validation
Authors: Aparna K. , Amilan S. , Raj L. Vimal 
Published: May 2023

Purpose
This study aims to develop and validate a scale to measure stakeholders' perception of mandatory corporate social responsibility (CSR) activities in the hotel industry in India.

Design/methodology/approach
CSR items were generated based on a qualitative approach. The underlying factorial structure of the scale is determined using exploratory factor analysis. The measurement model is verified through confirmatory factor analysis with validity checks. Additionally, the nomological and predictive validity of the proposed scale is confirmed through correlation and regression analysis.

Findings
This study proposed a three-dimensional 17-item scale comprising the environment, social and cultural domains to measure stakeholders' perception of mandatory CSR in the Indian hotel industry.

Research limitations/implications
This study adds to the literature by providing a comprehensive approach incorporating CSR activities specified by law on CSR measurement. Validated CSR scales are recommended for future studies to measure CSR in India. This study may also serve as a blueprint for other countries to develop context-specific CSR measurement approaches.

Originality/value
To the best of the authors’ knowledge, this is the first scale development study on mandatory CSR in India. The inclusion of CSR activities prescribed by law on the standardized CSR scale development is a novel outlook.
Evaluation of clinical factors and outcome of systemic glucocorticoid therapy discontinuation in patients with pemphigus achieving complete remission
Authors: Wang Mingyue , Li Jiaqi , Shang Panpan , Chong Shan , Chen Yan , Zhao Liuqi , Wang Rui , Fan Birao , Li Furong , Chen Xi , Zhang Yuexin , Zhao Junyu , Dang Jingyang , Chen Xixue , Zhu Xuejun 
Published: May 2023

AbstractTherapy discontinuation of systemic glucocorticoid treatment for pemphigus remains uncertain at the clinical end point of complete remission. The objective of this study was to identify the factors associated with achieving complete remission off therapy (CROT) and analyze the occurrence of relapse after therapy discontinuation. A retrospective cohort study was conducted at the Department of Dermatology of Peking University First Hospital. A total of 447 patients with pemphigus treated from 2005 to 2020 were identified. Univariate and multivariate analyses were conducted to analyze the associated factors of CROT and to evaluate the outcomes. The mean age was 48 years (±13.4 years), and 54.6% of the patients were women. During a median follow‐up of 59 months (43–87.5 months), 160 of 447 (35.8%) patients achieved CROT after a median treatment duration of 51 months (38–66.2 months). Patients with a shorter therapy duration to complete remission on minimal therapy and negative desmoglein antibodies tested in remission were more likely to achieve early CROT. Thirty‐five of 160 (21.9%) patients experienced relapse after CROT. Patients who discontinued therapy without guidance experienced significantly faster and higher occurrences of relapse than those withdrawing under guidance (log‐rank p = 0.01). Minimal therapy maintenance ≤8 months from complete remission on minimal therapy and positive desmoglein antibodies tested at withdrawal increased the risk of early relapse after CROT.
Use of a commercially available hydrogel as a novel DNA surface sampling tool
Authors: Sekowski Jennifer W. , Simmons Brooke , Lal‐Paterson Amrita , Armstrong Jamie , Rastogi Vipin K. , Angelini Daniel J. 
Published: May 2023

AbstractA common requirement in the military, law enforcement, and forensic mission space is the need to collect trace samples from surfaces using a method that not only readily captures the sample but also retains its integrity for downstream identification and characterization. Additionally, collecting samples from three‐dimensional objects (e.g., shell casings) is a challenge for which there is currently no validated standardized approach. Recently, hydrogels have been shown to have the potential for surface collection of trace bacterial spores, amino acids, and DNA. To test whether these hydrogels can serve as a viable collection medium for sampling DNA from surfaces, we carried out a series of preliminary tests examining collection efficiency and suitability of hydrogel material to recover samples of diluted, dried human DNA on a smooth polycarbonate surface. The recovery of surface DNA using a commercially available hydrogel was examined, and the efficiency compared to samples collected using a standard foam collection swab. DNA collected using the hydrogel and swab methods was then examined using quantitative polymerase chain reaction (qPCR) and short tandem repeat (STR) analysis to determine whether the collection material was compatible with these downstream processes. The hydrogel material used for this study collected the experimental DNA with comparable efficiency to standard collection swabs. In addition, qPCR and STR analyses demonstrated compatibility with the hydrogel collection and extraction process. These data suggest that hydrogels have the potential to be used as sample collection materials and deserve further characterization to elucidate their utility in collection from irregularly shaped, three‐dimensional surfaces/materials.
Emergent time‐spaces of working from home: Lessons from pandemic geographies
Authors: Orman Emily , MGuirk Pauline , Warren Andrew 
Published: May 2023

AbstractThe COVID‐19 pandemic and consequent health regulations compelled office‐based knowledge workers to work from home (WFH) en masse. Government and employer directives to WFH disrupted common norms of commuting to city office spaces and reshaped the geographies of office‐based knowledge work, with potentially lasting implications. Pandemic‐induced cohabitation of work‐space and home‐space saw more workers navigating the performance of paid labour in the home to produce new relational geographies of home, work, and worker. This paper provides a window on the lived experiences of the sizeable cohort of office‐based knowledge workers displaced from Sydney’s CBD to undertake WFH in the Illawarra region during the pandemic. We explore the unfolding pandemic geographies of work and home by drawing together feminist economic geography and geographies of home literatures. Our analysis reveals the emergent and variegated time‐spaces of WFH that emerged as the rhythms and routines of WFH shaped the home and vice versa. The analysis also reveals the differentiated agency of embodied workers to orchestrate emergent configurations of WFH, shaped by gender and by the socio‐materialities of home shaped by size, tenure, and life‐cycle stage. We conclude by drawing out important lines of analysis for further research as “hybrid work” evidently becomes entrenched post‐COVID.
Use of infrared thermography to detect reactions to stressful events: does animal personality matter?
Authors: MAZZAMUTO Maria Vittoria , MORANDINI Marina , LAMPMAN William , WAUTERS Lucas Armand , PREATONI Damiano , KOPROWSKI John Lad , MARTINOLI Adriano 
Published: May 2023

AbstractThe study of the relationship between animal stress and personality for free‐ranging animals is limited and provides contrasting results. The perception of stressors by an individual may vary due to its personality, and certain personality traits may help individuals to better cope with them. Using non‐invasive infrared thermography (IRT), we investigated the link between physiological and behavioral components expressed during an acute stress event by free‐ranging Fremont's squirrels (Tamiasciurus fremonti). We expected that, during the acute stress event of being approached by the researcher, individuals that showed a fast pace‐of‐life syndrome (bolder, more active, and less social/more aggressive) based on an arena test would exhibit stronger sympathetic‐adrenal‐medullary system reactivity showing a more intense stress‐induced hyperthermia (high core body temperature and low peripheral temperature) than individuals with a slow pace of life (shy, less active, and more social). We successfully employed IRT technology to images of Fremont's squirrels with identification of the individuals’ body parts (eye, nose, ear, hind foot). However, we found no support for our hypothesis. Squirrels’ body surface temperatures told us more about a squirrel's external environment and less about the thermal state of the body in that environment following a stressful event. Further studies need to assess how to make IRT effective and efficient in the field and improve its performance in studying the relationships between physiology and personality in wildlife.
Integrated water resources trend assessments: State of the science, challenges, and opportunities for advancement
Authors: Stackpoole Sarah M. , Oelsner Gretchen P. , Stets Edward G. , Hecht Jory S. , Johnson Zachary C. , Tesoriero Anthony J. , Walvoord Michelle A. , Chanat Jeff G. , Dunne Krista A. , Goodling Phillip J. , Lindsey Bruce D. , Meador Mike R. , Spaulding Sarah A. 
Published: May 2023

AbstractWater is vital to human life and healthy ecosystems. Here we outline the current state of national‐scale water resources trend assessments, identify key gaps, and suggest advancements to better address critical issues related to changes in water resources that may threaten human development or the environment. Questions like, “Do we have less suitable drinking water now than we had 20 years ago?” or “Are flood events more common now than they were in the past?” prompted improvements in data, trend estimation methods, and modeling frameworks to track changes in, and better understand how land use and climate influence four water resources domains: surface and groundwater quantity and quality. However, continued advancement in trend assessments to better address issues related to changes in water availability is needed. Areas of need include more timely and efficient delivery of water resources trend results and improved capacity to estimate trends at unmonitored locations. Additional integration pieces include increased understanding of groundwater–surface water interactions, incorporation of both quantity and quality trends into water availability estimates, and the refinement of trend metrics to account for the competing needs of society and ecological integrity. Coupled with improved driver attribution studies, these components will better inform current and future water resources management.
An easy tool to predict survival in patients with bone metastatic lung cancer treated with palliative radiotherapy
Authors: Makita Kenji , Hamamoto Yasushi , Kanzaki Hiromitsu , Nagasaki Kei , Kozuki Toshiyuki 
Published: May 2023

AbstractBackgroundThis study aimed to devise a simple assessment system for bone metastases (BMs) from lung cancer (LC).MethodsA total of 368 LC patients with BMs who underwent radiotherapy (RT) were retrospectively reviewed. Prognostic factors were evaluated using multivariate analysis, and a scoring system based on regression coefficients was devised.ResultsThe median follow‐up time for survival was 4.3 months, and the 0.5‐year overall survival (OS) rate was 44.7%. In the multivariate analysis, the significant prognostic factors were performance status (PS), metastases to internal organs, and post‐RT molecular‐targeting therapies (MTs) (tyrosine kinase inhibitors, and/or immune checkpoint inhibitors). A scoring system aggregating points assigned to each risk factor was created (2 points; non‐administration of post‐RT MTs, 1 point; PS ≥3 and metastases to internal organs). The median OSs were 25.0 months, 12.8 months, and 2.5 months in patients with a total score of 0 (n = 22), 1–2 (n = 124), and 3–4 (n = 221), respectively (p < 0.01).ConclusionThis easy‐to‐use scoring system is useful for selecting patients who received comparatively high‐dose fractionated RT for BMs from LC. Updates are required to follow the progress of systemic therapy.
Patchouli alcohol induces G0/G1 cell cycle arrest and apoptosis in vincristine‐resistant non‐small cell lung cancer through ROS‐mediated DNA damage
Authors: Liang Chi‐Yen , Chang Kai‐Fu , Huang Ya‐Chih , Huang Xiao‐Fan , Sheu Gwo‐Tarng , Kuo Chia‐Feng , Hsiao Chih‐Yen , Tsai Nu‐Man 
Published: May 2023

AbstractBackgroundLung cancer, especially non‐small cell lung cancer (NSCLC), is one of the leading causes of cancer‐related deaths worldwide. Vincristine (VCR) is a chemotherapeutic agent for lung cancers; however, its effectiveness is limited by side effects and the development of drug resistance. Patchouli alcohol (PA), from Pogostemon cablin extract, is known to possess anti‐inflammatory and anticancer properties. In this study, we investigated the role of PA in inducing reactive oxygen species (ROS)‐mediated DNA damage in A549 and VCR‐resistant A549/V16 NSCLC cells.MethodsThe anticancer potential of PA was studied using the MTT assay, colony formation, flow cytometry analysis, western blotting, DCFDA staining, immunofluorescence staining, and TUNEL assay techniques.ResultsThe intracellular ROS levels were enhanced in PA‐treated cells, activating the CHK1 and CHK2 signaling pathways. PA further inhibited proliferation and colony‐forming abilities and induced cell cycle arrest at the G0/G1 phase by regulating p53/p21 and CDK2/cyclin E1 expression. Moreover, PA increased the percentage of cells in the subG1 phase and induced apoptosis by activating the Bax/caspase‐9/caspase‐3 intrinsic pathway. In addition, drug resistance (p‐glycoprotein) and cancer stem cell (CD44 and CD133) markers were downregulated after PA treatment. Furthermore, combining PA and cisplatin exhibited synergistic inhibitory activity in A549 and A549/V16 cells.ConclusionsPA induced ROS‐mediated DNA damage, triggered cell cycle arrest and apoptosis, attenuated drug resistance and cancer stem cell phenotypes, and synergistically inhibited proliferation in combination with cisplatin. These findings suggest that PA has the potential to be used for the treatment of NSCLC with or without VCR resistance.
Dynamic model of entry: Dollar stores
Authors: Chenarides Lauren , Çakır Metin , Richards Timothy J. 
Published: May 2023

AbstractDollar stores have become the fastest‐growing retail format in the United States. However, there is considerable controversy regarding their entry, particularly into markets without grocery stores, and concerns that dollar‐store entry decisions are motivated by preemptive incentives. In this paper, we aim to study the market entry of dollar stores as an equilibrium phenomenon and to examine their impact on competing store formats in a dynamic environment. We use census‐tract level data and develop a dynamic model of oligopolistic competition to estimate the impact of dollar store entry on the equilibrium entry decisions of other retailers of the same format and other formats. We find that supermarkets and other large‐format owners thrive as dollar‐store expansion removes their “competitive fringe” in shared markets, whereas other small‐format stores (other dollar stores, convenience stores, and superettes) do not. Our findings have broad implications for the effect of dollar store entry on consumer welfare, as dollar‐store entry is not associated with grocery‐store exit but rather the exit of other small‐format stores.
Gastroprotective effect of sumatriptan against indomethacin‐, stress‐ and ethanol‐induced gastric damage in male rats: Possible modulatory role of 5‐hydroxytryptamine 1B/1D receptors and pro‐inflammatory cytokines
Authors: Ostovaneh Aysa , Eslami Faezeh , Rahimi Nastaran , Dejban Pegah , Shafaroodi Hamed , Abbasi Ata , Shahsavarhaghighi Shirin , Dehpour Ahmad Reza 
Published: May 2023

AbstractThe current study was aimed to investigate the beneficial effect of sumatriptan, a 5‐hydroxytryptamine 1B/1D (5HT1B/1D) receptor agonist, on gastric ulcer in rats via stimulating 5HT1B/1D receptors and suppressing pro‐inflammatory cytokines. Rats were allocated into three models of gastric ulcer: indomethacin (30 mg/kg, PO), water immersion restraint stress (WRS) and ethanol (5 ml/kg PO). Animals were administered with sumatriptan (0.01, 0.1, 0.3 and 1 mg/kg, i.p) 30 min before gastric ulcer induction. GR‐127935 (0.01 mg/kg, i.p, a selective 5HT1B/1D antagonist) was administered 30 min before sumatriptan (0.1 mg/kg) injection. Macroscopic assessments (J‐score), ELISA analysis of tumour necrosis factor‐alpha (TNF‐α) and interleukin‐1beta (IL‐1β) and histopathological changes were performed on the rat's stomach tissues. Gastric ulcer induction in three models caused an increase in J‐score, TNF‐α, IL‐1β and microscopic features. Sumatriptan (0.1 mg/kg) significantly improved gastric injury induced by indomethacin, WRS and ethanol through the reduction in the J‐score, TNF‐α, IL‐1β and microscopic lesions. Concurrent administration of GR‐127935 (0.01 mg/kg) with sumatriptan (0.1 mg/kg) reversed the gastroprotective effect of sumatriptan in three models. Sumatriptan possessed gastroprotective effects on indomethacin‐, WRS‐ and ethanol‐induced gastric damage in rats via the possible involvement of the 5HT1B/1D receptors.
Adolescent loneliness across the world and its relation to school climate, national culture and academic performance
Authors: Jefferson Rebecca , Barreto Manuela , Jones Frederick , Conway Jasmine , Chohan Aishwarya , Madsen Katrine Rich , Verity Lily , Petersen Kimberly J. , Qualter Pamela 
Published: May 2023

AbstractBackgroundLoneliness during adolescence has adverse consequences for mental health, education and employment outcomes. Yet, we know little about common correlates of loneliness among adolescents, making intervention work difficult.AimsIn this study, we (1) explore individual‐, school‐ and country‐level correlates of loneliness to help identify potential intervention targets, and (2) examine the influence of loneliness on academic performance.SampleA total of 518,210 students aged 15 years from 75 countries provided self‐reported loneliness data.ResultsUsing multilevel modelling, we found individual‐, school‐ and country‐level correlates of self‐reported school‐based loneliness, and showed that loneliness negatively influenced academic performance.ConclusionsBased on the findings, interventions that focus on enhancing social and emotional skills, increasing trust between teachers and students and changing school climate to be more inclusive are likely to be the most effective for adolescents; they should also be culturally sensitive.
Preschool teachers' pedagogical content knowledge predicts willingness to scaffold early science learning
Authors: Schmitt Lukas , Weber Anke , Venitz Laura , Leuchter Miriam 
Published: May 2023

AbstractBackgroundThe importance of diagnostic and scaffolding activities for early science learning has been shown consistently. However, preschool teachers scarcely engage in them. We developed an instrument to assess preschool teachers' willingness to engage in diagnostic and scaffolding activities in science learning situations and examined its relation with teachers' knowledge, beliefs and practice.AimsWe validate an instrument to assess willingness to engage in scaffolding and diagnostic activities and study the interplay between willingness, learning beliefs, content knowledge (CK) and pedagogical content knowledge (PCK) in the context of science learning, particularly block play.Sample(s)A total ofN = 151 preschool teachers from 41 kindergartens in Germany participated in our study.MethodsPreschool teachers completed a questionnaire, which took approximately 1 hour of time. We drew a subsample ofN = 73 teachers and observed their practice during a 30 min block play episode.ResultsWith our instrument, we were able to distinguish between preschool teachers' willingness to diagnose and to scaffold. Preschool teachers' co‐constructivist beliefs and PCK predicted willingness to engage in diagnosing, PCK also predicted willingness to engage in scaffolding. Associations between learning beliefs and practice were inconsistent.ConclusionsOur study highlights aspects of the association between preschool teachers' PCK and their willingness to engage in diagnosing and scaffolding. However, we found inconsistencies between preschool teachers' beliefs and practice, which call for further clarification.
Accuracy of immediate dental implant placement with task‐autonomous robotic system and navigation system: An in vitro study
Authors: Chen Jinyan , Zhuang Minjie , Tao Baoxin , Wu Yiqun , Ye Lijuan , Wang Feng 
Published: May 2023

AbstractObjectivesThe aim of this study was to compare the accuracy of dental implant placement in a single tooth gap, including the postextraction site and healed site, using a task‐autonomous robotic system and a dynamic navigation system.Materials and MethodsForty partially edentulous models requiring both immediate and conventional implant placement were randomly divided into a robotic system group and a navigation system group. The coronal, apical, and angular deviations of the implants were measured and assessed between the groups.ResultsThe deviations in immediate implant placement were compared between the robotic system and dynamic navigation system groups, showing a mean (±SD) coronal deviation of 0.86 ± 0.36 versus 0.70 ± 0.21 mm (p = .101), a mean apical deviation of 0.77 ± 0.34 versus 0.95 ± 0.38 mm (p = .127), and a mean angular deviation of 1.94 ± 0.66° versus 3.44 ± 1.38° (p < .001). At the healed site, significantly smaller coronal deviation (0.46 ± 0.29 vs. 0.70 ± 0.30 mm, p = .005), apical deviation (0.56 ± 0.30 vs. 0.85 ± 0.25 mm, p < .001), and angular deviation (1.36 ± 0.54 vs. 1.80 ± 0.70 mm, p = .034) were found in the robotic system group than in the dynamic navigation group.ConclusionsThe position in both immediate and conventional implant placement was more precise with the task‐autonomous robotic system than with the dynamic navigation system. Its performance in actual clinical applications should be confirmed in further trials.
A review of population and landscape level dynamics associated with pneumonia outbreaks in bighorn sheep with implications for land management
Authors: Paolini Kelsey E. , Schwartz Michael K. , Friggens Megan M. , Cushman Samuel A. , Weckworth Julie K. , Holbrook Joseph D. 
Published: May 2023

AbstractWildlife conservation necessitates understanding spatiotemporal drivers that facilitate disease outbreaks. Wildlife diseases are influenced by population and landscape level factors which affects host species’ persistence through time. Recurrent pneumonia outbreaks in bighorn sheep have impeded population recovery throughout the western US. Recovery efforts have included translocating animals, limiting contact with known reservoirs, removing infected individuals, and depopulating herds, but pneumonia outbreaks continue to negatively impact recovery. Here, our objective was to systematically review the current literature focused on population and landscape level drivers that can contribute to pneumonia outbreaks in bighorn sheep. We reviewed 115 studies and discovered consistent themes important to address for future conservation. One of the primary themes to advance management includes understanding how population demographics, such as age and sex cohorts, can help elucidate drivers and maintenance of pathogens associated with respiratory disease. Second, broadening knowledge of landscape level processes including population connectivity and metapopulation dynamics can inform management and recovery efforts. We identified a need for comprehensive assessments that incorporate population dynamics, landscape genomics, and population connectivity across multiple spatiotemporal scales to advance landscape management. Finally, we provide directions for future research to help managers mitigate pneumonia outbreaks and aid bighorn sheep recovery.