bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of Several Types and Doses of Organic Fertilizer on The Growth and Production of Pakcoy Plant (Brassica chinensis)
Authors: Sondang Y , Wulantika T , Alfina R , Sembiring N , Hardaningsih W , Wahono S , Yefriwati  , Ritawati  
Published: August 2023

Abstract
Pakcoy is one of the Brassicaceae family’s vegetable plants which is currently highly very popular with the public. Pakcoy production in West Sumatra continues to decline due to the continuous use of inorganic fertilizers. Chicken manure is a particular kind of organic fertilizer alternative that can replace inorganic fertilisers. This study’s objective is to ascertain the impact of various organic fertilizer types with different bio activators and doses on development and plant production. Experiment was compiled utilizing a factorial pattern set up in a Randomized Block Design (RBD) with the first treatment of organic fertilizer varieties, namely: Chicken manure (CM), Chicken manure with N21 bio activator (CMN), and Chicken manure with banana weevil LMO bio activator (CMM). The second treatment of doses of organic fertilizers: 5, 10, 15, and 20 t.ha−1. The treatment combined was repeated 3 times, for a total of 36 experimental units and each experimental unit had 9 clumps of plants. The measured value was examined using the STAT program and followed by the DMRT test. The findings indicated that the application of chicken manure + banana weevil LMO gave the best results toward leaf length, leaf width, canopy width, number of leaves, wet weight, and dry weight pakcoy plant
Evaluation System of Intercropping Functional Food Sweet Corn and Vegetable Soybean in Different Planting Density and Compound Fertilizers Dosages
Authors: Darini Maria Theresia , Widata Sri , Setiawati Evi , Astuti Ari 
Published: August 2023

Abstract
This study evaluated the sweet corn and vegetable soybeans intercropping system when applying various organic fertilizer sources and NPK fertilizer dosage. Conducted from June until August 2022 in Umbulharjo village, Yogyakarta, the study was carried out in factorial Randomized Complete Block Design under three replications. The first factor was density plant hill−1 consisting fourt levels (1+1; 2+1; 1+2; 2+2), the second was NPK dosage comprising three levels (100, 200, 300) kg ha−1, which eventually gained 42 units of plots. The observation variables involve components of yield, growth, and land efficiency. Variance test (ANOVA) at a value significant at 5% was used to analyze research data statistically and then followed by Duncan’s Multiple Range Test at the same significance level. The result indicated that applying a combination of chicken manure under NPK dosage of 300 kg ha−1 showed the sweet corn and vegetable soybean intercropping’s finest growth and yield, and the land efficiency component presented a Land Equivalent Ratio of 1.55 and Competition index of 0.92.
Physicochemical and microbiological study of Dadiah jelly candy with the addition of Clitoria ternatea flower extract
Authors: Juliyarsi I , Sandra A , Melia S , Setiawan R D , Nurhayati  , Pangestu S 
Published: August 2023

Abstract
Dadiah is a traditional fermented buffalo milk originating from West Sumatra, Indonesia and has health benefits. The aim of this study was to evaluate the effect of the addition of Clitoria ternatea flower extract addition (0,5%, 1%, 1,5%, and 2%) on the moisture content, hardness, total lactic acid bacteria, antioxidant activity, and total phenolic content of dadiah jelly candies. The results showed that the addition of Clitoria ternatea extract increased the moisture content, decreased the hardness value, increased the total phenolic content, and enhanced the antioxidant activity of the jelly candies. Compared to the dadiah jelly candies without Clitoria ternatea addition, jelly candies with Clitoria ternatea addition at any concentration did not differ significantly (P > 0.05) in total lactic acid bacteria, whereas the pH value increased as the concentration of the Clitoria ternatea extract increased. Overall, the use of Clitoria ternatea flower extract can improve the functional properties of dadiah jelly candies, with the best concentration of 2% of the Clitoria ternatea extract on the antioxidant activity and total phenol content.
Utilization of Sago Solid Waste for Bioethanol Production With Variation of Sago Solid Waste-Solvent Ratio and Pre-treatment Time
Authors: Chairul  , Ridho M H , Zultiniar  , Hendra Alfino 
Published: August 2023

Abstract
Sago solid waste is a lignocellulosic material that can be used as a raw material for making bioethanol. The lignin component of lignocellulose can slow saccharification by preventing cellulase enzymes from accessing cellulose. The pre-treatment stage is the first stage of the lignocellulose-to-bioethanol conversion process, and it is used to lower lignin levels in lignocellulose. Saccharification and fermentation are the next processes in turning lignocellulosic material to bioethanol. The pre-treatment stage was carried out in this study using a 10% NaOH solution at a 4 bar pressure reactor and a temperature of 140 °C, while the saccharification and fermentation stages were carried out simultaneously (SSF) using cellulase enzymes and yeast Saccharomyces cerevisiae at 30 °C and pH 5. The ratio of sago solid waste to NaOH solution and the period of the pre-treatment process were varied in the study. The sago solid waste to solvent ratios were 1:5, 1:6, and 1:7, with processing times beginning at 20 minutes, 30 minutes, and 40 minutes. The maximum lignin reduction results (60.11%) were obtained at a ratio of 1:7 and a pre-treatment time of 40 minutes, while the highest yield of sago solid waste mass (35.14%) was obtained at a ratio of 1:5 and a pre-treatment process duration of 20 minutes. The results of the initial treatment stage were then continued with SSF for 0 hours, 24 hours, 48 hours, and 72 hours with the highest bioethanol content of 12% at 72 hours.
Membrane Sensor Polyvinyl Chloride with Immobilization Dithizone for Determination of Nickel (II) Ion
Authors: Lisdiana Hayyun , Moersilah  , Manullang Dosmaria 
Published: August 2023

Abstract
A simple analytical method, cheap and biologically friendly, to find Ni (II) in drinking water was developed by dithizone immobilization in chloride polyvinyl matrix (PVC) and dioctyl phthalate as plasticizers. Nickel is a toxic and dangerous metal for humans and the environment. The step experimented with making a membrane sensor next to the step characterization of membrane sensor with UV-Vis spectrophotometry, atomic absorption spectrophotometry (AAS), and characterization with SEM. The absorption of Ni (II) ion has caused the change of color from green to brownish red with maximum absorption in 418 nm and the optimum response of membrane sensor gaining on pH 8,8. The proposed membrane sensor size is 1 x 2 cm, and the sample volume is 2 ml with a 0 - 0.06 ppm concentration range. The method that had been applied to determining Ni (II) in a water sample after the addition of standard solution with a recovery of 82.93-109.49 % in UV-Vis spectrophotometry, while atomic absorption spectrophotometry measurements obtained a recovery of 104.11-107.96 %. The Nickel contained in drinking water cannot exceed the regulation of quality drinking water by PERMENKES RI No: 907/KEMENKES/PER/VII/2010.
Effect of Electrolyte Concentration on Characteristics of Activated Carbon of Cocoa Peel
Authors: Yetri Yuli , Afza Vikra Yudha Yolanda , Julsam  , Ganumba Oktavianus , Sunitra Eka 
Published: August 2023

AbstractCocoa peel activated carbon has been successfully synthesized with 0.3 M KOH activator and NaCl electrolyte as the base material for supercapacitor electrodes. Variations in the concentration of NaCl electrolyte used were 1 M, 2 M, and 3 M to determine their effect on the capacitance, conductivity, and pore area values produced. The activated carbon produced was characterized by Scanning Electronic Microscope (SEM) to see surface morphology, X-Ray Diffraction (XRD) to determine carbon crystals, Cyclic Voltammetry (CV) and LCR-Meter to determine capacitance and conductivity values, and the Brunauer Emmett Teller method. (BET) to measure its surface area. The results of the Indonesian National Standard (SNI) test results obtained water content (8.6%), ash content (8.7%), volatile matter (26.2%), carbon content (65.1%), and iodine absorption (800 mg/g). The pore surface area can be increased by activation up to 24,742 m2/g. XRD analysis shows that the atomic structure is amorphous. Surface morphology proves that the increase in NaCl electrolyte concentration affects the pore structure. The higher the electrolyte concentration, the more even and finer the pore structure will be. The highest specific capacitance value was obtained at 3 M NaCl, which was 1.68375 F/g and the lowest was at 0.10771 F/g NaCl 1 M. The conductivity obtained is 1.83 S/m at 3 M NaCl at frequency of 1000 Hz and the lowest is 0.18 S/m at 1 M NaCl at 100 Hz. This proves that the electrolyte concentration can affect and increase the value of the capacitance and conductivity of the supercapacitor electrode.
Expressive curves
Authors: Fomin Sergey , Shustin Eugenii 
Published: August 2023

We initiate the study of a class of real plane algebraic curves which we call expressive. These are the curves whose defining polynomial has the smallest number of critical points allowed by the topology of the set of real points of a curve. This concept can be viewed as a global version of the notion of a real morsification of an isolated plane curve singularity.

We prove that a plane curve

C
C

is expressive if (a) each irreducible component of

C
C

can be parametrized by real polynomials (either ordinary or trigonometric), (b) all singular points of

C
C

in the affine plane are ordinary hyperbolic nodes, and (c) the set of real points of

C
C

in the affine plane is connected. Conversely, an expressive curve with real irreducible components must satisfy conditions (a)–(c), unless it exhibits some exotic behaviour at infinity.

We describe several constructions that produce expressive curves, and discuss a large number of examples, including: arrangements of lines, parabolas, and circles; Chebyshev and Lissajous curves; hypotrochoids and epitrochoids; and much more.
Prevalence and Correlates of Uncontrolled Hypertension, Persistently Uncontrolled Hypertension, and Hypertensive Crisis at a Healthcare System
Authors: Mahabaleshwarkar Rohan , Bond Allan , Burns Ryan , Taylor Yhenneko J , McWilliams Andrew , Schooley John , Applegate William B , Little Gary 
Published: August 2023

Abstract

BACKGROUND
Uncontrolled hypertension significantly increases risk of cardiovascular disease and death. This study examined the prevalence of uncontrolled hypertension, persistently uncontrolled hypertension, and hypertensive crisis and factors associated with these outcomes in a real-world patient cohort.

METHODS
Electronic medical records from a large healthcare system in North Carolina were used to identify adults with uncontrolled hypertension (last ambulatory blood pressure [BP] measurement ≥140/90); persistently uncontrolled hypertension (≥2 ambulatory BP measurements with all readings ≥140/90); and hypertensive crisis (any BP reading ≥180/120) in 2019. Generalized linear mixed models tested the association between patient and provider characteristics and each outcome.

RESULTS
The study cohort included 213,836 patients (mean age 63.1 (±14.0) years, 55.5% female, 70.8% white). Of these, 29.7% and 13.1% had uncontrolled hypertension and hypertensive crisis, respectively. Among those experiencing hypertensive crisis, &gt;50% did not have uncontrolled hypertension. Of the 171,061 patients with ≥2 BP measurements, 5.9% had persistently uncontrolled hypertension. The likelihood of uncontrolled hypertension, persistently uncontrolled hypertension, and hypertensive crisis was higher in patients with black race (vs. white), self-pay (vs. private), prior emergency room visit, and no attributed primary care provider. Readings taken in the evening (vs. morning) and at specialty (vs. primary care) practices were more likely to meet thresholds for uncontrolled hypertension and hypertensive crisis.

CONCLUSIONS
Hypertension control remains a significant challenge in healthcare. Health systems may benefit from segmenting their patient population based on factors such as race, prior healthcare use, and timing of BP measurement to prioritize outreach and intervention.
Persistence and Dose Escalation During Maintenance Phase and Use of Nonbiologic Medications Among Patients With Ulcerative Colitis Initiated on Ustekinumab in the United States
Authors: Zhdanava Maryia , Zhao Ruizhi , Manceur Ameur M , Kachroo Sumesh , Lefebvre Patrick , Pilon Dominic 
Published: August 2023

Abstract

Background
Real-world data on treatment patterns among patients with ulcerative colitis (UC) initiated on ustekinumab are limited.

Methods
Adults with UC initiated on ustekinumab (index date) between 10/18/2019 and 04/31/2022 were selected from a deidentified health insurance claims database (Symphony Health, an ICON plc Company, PatientSource). Persistence (no gaps in days of supply &gt;120 days), persistence while being corticosteroid-free (no corticosteroid use for ≥14 days of supply after a 90-day grace period from index date) and dose escalation (≥2 consecutive subcutaneous claims ≥100% above daily maintenance dose) were described during the maintenance phase using Kaplan–Meier analysis. Nonbiologic treatments, among patients with ≥2 ustekinumab claims within 90 days post-index and ≥6 months of follow-up, were compared with logistic models 6 months post- versus pre-ustekinumab initiation.

Results
6565 patients on ustekinumab entered the maintenance phase. At month 12 of the maintenance phase, 72.0% (95% confidence interval [CI]: 70.1%–73.9%) were persistent, 50.8% (95% CI: 48.7%–52.9%) were persistent and corticosteroid-free, and 19.2% (95% CI: 17.3%–21.3%) of patients had dose escalation. In the 6 months post- versus pre-ustekinumab initiation, the odds of nonbiologic medication use assessed in 4147 patients were significantly lower: 57% lower odds for corticosteroid, 46% for 60 cumulative days of corticosteroid, 42% for 5-aminosalicylic acid, and 24% for immunomodulators (all P &lt; .001).

Conclusions
Most patients with UC reaching the maintenance phase on ustekinumab remained persistent after 12 months of maintenance therapy. Nonbiologic medication use post-ustekinumab initiation was significantly lower, notably for corticosteroids. Given the multiple complications associated with chronic corticosteroid use, this reduction can be seen as clinically relevant and informs treatment choice for patients with UC.
Prognostic significance of haemodynamic parameters in patients with cardiogenic shock
Authors: Berg David D , Kaur Gurleen , Bohula Erin A , Baird-Zars Vivian M , Alviar Carlos L , Barnett Christopher F , Barsness Gregory W , Burke James A , Chaudhry Sunit-Preet , Chonde Meshe , Cooper Howard A , Daniels Lori B , Dodson Mark W , Gerber Daniel A , Ghafghazi Shahab , Gidwani Umesh K , Goldfarb Michael J , Guo Jianping , Hillerson Dustin , Kenigsberg Benjamin B , Kochar Ajar , Kontos Michael C , Kwon Younghoon , Lopes Mathew S , Loriaux Daniel B , Miller P Elliott , O’Brien Connor G , Papolos Alexander I , Patel Siddharth M , Pisani Barbara A , Potter Brian J , Prasad Rajnish , Roswell Robert O , Shah Kevin S , Sinha Shashank S , Smith Timothy D , Solomon Michael A , Teuteberg Jeffrey J , Thompson Andrea D , Zakaria Sammy , Katz Jason N , van Diepen Sean , Morrow David A 
Published: August 2023

Abstract

Aims
Invasive haemodynamic assessment with a pulmonary artery catheter is often used to guide the management of patients with cardiogenic shock (CS) and may provide important prognostic information. We aimed to assess prognostic associations and relationships to end-organ dysfunction of presenting haemodynamic parameters in CS.

Methods and results
The Critical Care Cardiology Trials Network is an investigator-initiated multicenter registry of cardiac intensive care units (CICUs) in North America coordinated by the TIMI Study Group. Patients with CS (2018–2022) who underwent invasive haemodynamic assessment within 24 h of CICU admission were included. Associations of haemodynamic parameters with in-hospital mortality were assessed using logistic regression, and associations with presenting serum lactate were assessed using least squares means regression. Sensitivity analyses were performed excluding patients on temporary mechanical circulatory support and adjusted for vasoactive-inotropic score. Among the 3603 admissions with CS, 1473 had haemodynamic data collected within 24 h of CICU admission. The median cardiac index was 1.9 (25th–75th percentile, 1.6–2.4) L/min/m2 and mean arterial pressure (MAP) was 74 (66–86) mmHg. Parameters associated with mortality included low MAP, low systolic blood pressure, low systemic vascular resistance, elevated right atrial pressure (RAP), elevated RAP/pulmonary capillary wedge pressure ratio, and low pulmonary artery pulsatility index. These associations were generally consistent when controlling for the intensity of background pharmacologic and mechanical haemodynamic support. These parameters were also associated with higher presenting serum lactate.

Conclusion
In a contemporary CS population, presenting haemodynamic parameters reflecting decreased systemic arterial tone and right ventricular dysfunction are associated with adverse outcomes and systemic hypoperfusion.
Predicting poor neurological outcomes following out-of-hospital cardiac arrest using neuron-specific enolase and neurofilament light chain in patients with and without haemolysis
Authors: Abdi Isse Yusuf , Frikke-Schmidt Ruth , Wiberg Sebastian , Grand Johannes , Obling Laust E R , Meyer Anna Sina Pettersson , Kjaergaard Jesper , Hassager Christian , Meyer Martin A S 
Published: August 2023

Abstract

Aims
Hypoxic-ischaemic brain injury following out-of-hospital cardiac arrest (OHCA) is a common complication and a major cause of death. Neuron-specific enolase (NSE) and neurofilament light chain (NfL) are released after brain injury and elevated concentrations of both are associated with poor neurological outcome. We explored the influence of haemolysis on the prognostic performance of NSE and NfL.

Methods and results
The study is based on post hoc analyses of a randomized, single-centre, double-blinded, controlled trial (IMICA), where comatose OHCA patients of presumed cardiac cause were included. Free-haemoglobin was measured at admission to quantify haemolysis. NSE and NfL were measured after 48 h to estimate the extent of brain injury. Montreal Cognitive Assessment score (MoCA) was assessed to evaluate neurocognitive impairments. Seventy-three patients were included and divided into two groups by the median free-haemoglobin at admission. No group differences in mortality or poor neurological outcome were observed. The high-admission free-haemoglobin group had a significantly higher concentration of NSE compared to the low-admission free-haemoglobin group (27.4 µmol/L vs. 19.6 µmol/L, P = 0.03), but no differences in NfL. The performance of NSE and NfL in predicting poor neurological outcome were high for both, but NfL was numerically higher [area under the ROC (AUROC) 0.90 vs. 0.96, P = 0.09]. Furthermore, NfL, but not NSE, was inversely correlated with MoCA score, R2 = 0.21, P = 0.006.

Conclusion
High free-haemoglobin at admission was associated with higher NSE concentration after 48 h, but, the performance of NSE and NfL in predicting poor neurological outcome among OHCA patients were good regardless of early haemolysis. Only elevated NfL concentrations were associated with cognitive impairments.
Identification of myokines susceptible to improve glucose homeostasis after bariatric surgery
Authors: Orioli Laura , Canouil Mickaël , Sawadogo Kiswendsida , Ning Lijiao , Deldicque Louise , Lause Pascale , de Barsy Marie , Froguel Philippe , Loumaye Audrey , Deswysen Yannick , Navez Benoit , Bonnefond Amélie , Thissen Jean-Paul 
Published: August 2023

Abstract

Importance and Objective
The identification of myokines susceptible to improve glucose homeostasis following bariatric surgery could lead to new therapeutic approaches for type 2 diabetes.

Methods
Changes in the homeostasis model assessment (HOMA) test were assessed in patients before and 3 months after bariatric surgery. Changes in myokines expression and circulating levels were assessed using real-time quantitative polymerase chain reaction (RT-qPCR) and enzyme-linked immunosorbent assay (ELISA). Myokines known to regulate glucose homeostasis were identified using literature (targeted study) and putative myokines using RNA-sequencing (untargeted study). A linear regression analysis adjusted for age and sex was used to search for associations between changes in the HOMA test and changes in myokines.

Results
In the targeted study, brain-derived neurotrophic factor (BDNF) expression was upregulated (+30%, P = .006) while BDNF circulating levels were decreased (−12%, P = .001). Upregulated BDNF expression was associated with decreased HOMA of insulin resistance (HOMA-IR) (adjusted estimate [95% confidence interval {CI}]: −0.51 [−0.88 to −0.13], P = .010). Decreased BDNF serum levels were associated with decreased HOMA of beta-cell function (HOMA-B) (adjusted estimate [95% CI] = 0.002 [0.00002-0.0031], P = .046). In the untargeted study, upregulated putative myokines included XYLT1 (+64%, P &lt; .001), LGR5 (+57, P &lt; .001), and SPINK5 (+46%, P &lt; .001). Upregulated LGR5 was associated with decreased HOMA-IR (adjusted estimate [95% CI] = −0.50 [−0.86 to −0.13], P = .009). Upregulated XYLT1 and SPINK5 were associated with increased HOMA of insulin sensitivity (HOMA-S) (respectively, adjusted estimate [95% CI] = 109.1 [28.5-189.8], P = .009 and 16.5 [0.87-32.19], P = .039).

Conclusions
Improved glucose homeostasis following bariatric surgery is associated with changes in myokines expression and circulating levels. In particular, upregulation of BDNF, XYLT1, SPINK5, and LGR5 is associated with improved insulin sensitivity. These results suggest that these myokines could contribute to improved glucose homeostasis following bariatric surgery.

Study registration
NCT03341793 on ClinicalTrials.gov (https://clinicaltrials.gov/).
Communication Breakdown: Sports Federations and Media Politics in the Weimar Republic
Authors: Young Christopher 
Published: August 2023

Abstract
Organized sport in the Weimar Republic was dominated by three strands—so-called bourgeois sport, the gymnastics movement (Turnen) and the workers’ sports movement (Arbeitersport). While scholarship has rightly pointed out the differences between their federations, it has neglected a significant feature they had in common: the struggle to communicate key messages to their members. For the first time, this article examines debates about and developments in the communications of Weimar’s leading sports organizations. It shows that through the 1920s producing journals, running news services and lobbying the press became as important as competing in or watching sport itself, as the organizations sought to raise their profile, gain new members and retain the members they already had. Each of them, while envying the others, failed to meet its goals for similar reasons: inadequate internal structures, poor decision-making and the allure of commercialized sport and the papers and magazines it fed and produced. While scholarship has often noted the high level of sports coverage in the mainstream press, it has not explored the dynamic pull of such reporting on readers. By examining the effects of the professional media on the active members of the three main federations, this article therefore also sheds light on the power of new forms of writing and entertainment to influence individuals as the shift to consumer habits increased in all social classes throughout the Weimar Republic. In doing so, it bridges between empirically orientated forms of sports history and cultural histories of the press.