bluuebunny/crossref_metadata_2025_split huggingface dataset:
Étude des connaissances, pratiques et attitudes des étudiants de l’université de Mohammed Premier d’Oujda vis-à-vis les hépatites virales au Maroc
Authors: Lekfif Asmae , Atassi Mariam , Salah Anass , Rahhaoui Sara , Sabbar Sanae , Aissaoui Hanane , Yeznasni Asmae , Bouazzaoui Mohammed Amine , Abda Naima 
Published: January 2025

Introduction : À l'échelle mondiale et au Maroc, les hépatites virales constituent l'une des priorités majeures de la santé publique ; la connaissance et la sensibilisation constituent un des piliers essentiels pour la lutte contre ces affections.
Objectif : Evaluer les connaissances, attitudes et pratiques des étudiants universitaires concernant les hépatites virales, et déterminer les facteurs associés aux bonnes connaissances sur les hépatites virales.
Méthodes : Une étude transversale descriptive et analytique a été menée auprès des étudiants inscrits à l’Université Mohammed Premier d’Oujda, pour l’année universitaire 2023-2024, à l’aide d’un questionnaire en ligne auto-administré et anonyme.
Résultats : 503 étudiants avaient rempli le questionnaire en ligne. Les résultats ont montré que les hépatites B (73,6%) et C (67,4%) étaient plus connues que les hépatites A (52,0%) et E (24,3%). Plus des deux tiers des étudiants savaient que le VHB peut se transmettre par voie sanguine et par voie sexuelle et que l’hépatite C se transmet principalement par vois sanguine. La transmission des virus de l'HVA et de l'HVE était connue par 43,5%. Le niveau de connaissance sur les hépatites était significativement associé au niveau d'études, l’affiliation à la faculté de médecine, et au statut socio-économique. Concernant les attitudes et les pratiques des étudiants, nous avons noté que plus des deux tiers adoptent des mesures de précaution contre les hépatites, et 70% ont déclaré qu’ils refuseraient de partager un plat avec une personne atteinte de l’hépatite quel que soit le type du virus ...( résumé tronqué à 250 mots).
Impact de l'éducation thérapeutique sur la qualité de vie des patients coronariens : Etude interventionnelle
Authors: Ghali Hela , Elhraiech Aymen , Ben Souda Hend , Karray Majdi , Pavy Bruno , Zedini Chekib 
Published: January 2025

Objectif : Déterminer l’impact d’un programme d’éducation thérapeutique du patient (ETP) sur la qualité de vie des patients coronariens au CHU Sahloul de Sousse.
Méthodes : une étude interventionnelle a été menée durant une période de sept mois allant du mois de Mai 2022 à Novembre 2022, auprès des patients hospitalisés au service de cardiologie de l'Hôpital universitaire Sahloul. Les participants ont été répartis en deux groupes, intervention et contrôle. Le groupe d'intervention a bénéficié d'un programme d'ETP. Le groupe contrôle a suivi les consultations habituelles à l’hôpital. L’évaluation de la qualité de vie liée à la santé a été faite trois mois après la fin du programme éducatif, en utilisant la version tunisienne validée de SF-12.
Résultats : Sur les 129 patients inclus, 38 ont suivi le programme d'éducation tandis que 91 étaient dans le groupe contrôle. Les caractéristiques sociodémographiques ont révélé une prédominance masculine dans la population étudiée, avec un âge moyen similaire entre les deux groupes. Les principaux facteurs de risque cardiovasculaire identifiés étaient le tabagisme, l'hypertension et le diabète. Ce programme a conduit à une amélioration de la qualité de vie des patients. Ainsi, les patients qui ont participé au programme d’ETP avaient des scores significativement plus élevés que le groupe témoin dans les rubriques du rôle physique, rôle émotionnel, douleur corporelle, fonction sociale, et des scores de santé physique et santé mentale avec des différences statistiquement significatives.
Conclusion : Notre étude souligne l'importance cruciale de l'éducation thérapeutique dans l'amélioration ...( résumé tronqué à 250 mots).
Analisis Keton Urine Penderita Diabetes Mellitus (DM) Tipe 2
Authors: Syahruni Susi Susanti , Aryandi Rahmat , Asnidar Asdinar 
Published: January 2025

Diabetes mellitus tipe 2, gangguan metabolik kronis yang melibatkan resistensi insulin atau penurunan sekresi insulin, menunjukkan prevalensi meningkat secara signifikan di Kabupaten Bulukumba, termasuk di Puskesmas Bontonyeleng. Kondisi ini berpotensi menyebabkan komplikasi serius seperti ketoasidosis diabetik (KAD) akibat keton yang berlebihan dalam tubuh. Penelitian ini menggunakan desain penelitian deskriptif. Dengan metode Diptick carik celup menggunakan alat urine analyzer. Sampel yang di ambil sebanyak 13 dengan teknik porposive sampling pada pasien diabetes mellitus tipe 2 di Puskesmas Bontonyeleng dengan jumlah populasi 359. Hasil penelitian diperoleh hasil negatif dengan persentase (100%), yang berarti pada pemeriksaan urin pada penderita diabetes melitus tipe 2 tidak ditemukan keton urine. dan Berdasarkan penelitian yang telah dilakukan dapat disimpulkan bahwa keton pada urine penderita diabetes mellitus tipe 2 didapatkan semua negatif.
PENGARUH KEPUASAN KERJA DAN MOTIVASI KERJA TERHADAP LOYALITAS PEGAWAI NON MEDIS PADA RUMAH SAKIT UMUM DAERAH SANJIWANI DI KABUPATEN GIANYAR
Authors: Fitriandari Mahayanti , Nindia Putri Cokorda Istri Agung Vera , Ananditha Ida Bagus Ruby 
Published: January 2025

The study's objectives were to ascertain if job satisfaction and work motivation had a concurrent, partial, and substantial impact on the loyalty of non-medical staff at the Sanjihani General Hospital in Gianyar Regency. The proportionate random sampling technique was used to determine the sample size, which could be as many as 68 individuals. Stratified random sampling was used to carry out the sampling, meaning that the number of non-medical staff in each field under study affected how many samples were taken. The traditional assumption test, multiple linear regression coefficient analysis, determination analysis, F test statistical analysis, and t test statistical analysis were all used to analyse the data. The findings demonstrated a favourable and substantial influence on job satisfaction and work motivation on the loyalty of non-medical staff at the Sanjiwani Regional General Hospital in Gianyar Regency, either concurrently or partly.
SOSIALISASI PENGELOLAAN SAMPAH ORGANIK BERBASIS SUMBER DENGAN PEMBUATAN “TEBE MODERN” PADA PESERTA DIDIK SMP DHARMA PRAJA BADUNG
Authors: Suanda I Wayan , Rusmayanthi Kadek Intan , Sumada I Made , Alit Dewa Made 
Published: January 2025

The management of waste produced by community households is not yet optimal, especially the handling of organic waste. To reduce the negative impact of organic waste whose management is not optimal, community service is carried out in the form of education and socialization of the application of organic waste processing by creating "Tebe Modern". This service activity is carried out using a descriptive evaluative method which is carried out by describing and analyzing the situation of the land used and maximized by socialization activities about how to process source-based waste by making "Tebe Modern". The results of this community service activity produced very good results, marked by high appreciation and enthusiasm from students, related agencies and community leaders.
Children's Perspectives towards the Elderly - A Cross-Sectional Survey
Authors: Dsouza Josmitha Maria , Kamath Neetha 
Published: January 2025

Background: With an aging global population, understanding the perceptions and attitudes of younger generations toward the elderly becomes increasingly vital for promoting intergenerational rapport and encouraging social cohesion.Objective: The purpose of this investigation was to evaluate the attitudes of children towards the elderly. Methods: A cross-sectional analysis was conducted among 384 children between the ages of 7-14 in selected schools of Mangaluru, Karnataka, India. The data was collected using a pre-validated rating scale. Results: The children's mean score on the attitude towards the elderly scale was 27.08±4.39, indicating that the 89.06% have a favorable attitude towards the elderly. Moreover, a significant association was found between the children's perspective towards the elderly and the demographic variables like age (P= 0.003), class (P <0.001), and type of family (P <0.001).Conclusion: Interventions and educational programs can be designed to cultivate positive attitudes about the elderly among children, which can eventually contribute to the creation of age-friendly communities.
Incidence, Prevalence, and Molecular Identification of Sclerotium rolfsii Causing Southern Blight in Tomato Fields of Mysuru District, Karnataka, India
Authors: Aljabali Mansour Abdel Rahman Ahmad , V Basavaraj , M R Sampathkumar , M S Sharada 
Published: January 2025

Introduction: Tomato (Solanum lycopersicum), a vital crop worldwide, is under significant threat from Sclerotium rolfsii, the fungal pathogen responsible for southern blight. This soil-borne pathogen, known for its wide host range and destructive nature, thrives in humid environments, causing severe losses in tomato production.
Aim: A field survey was conducted between June and September 2024 across 30 villages in six taluks of Mysuru district, Karnataka, India, to assess the incidence, prevalence, and severity of southern blight in tomato fields.
Results: Disease incidence ranged from 10.73% to 69.64%, while prevalence varied between 20% and 83.33%. Mysuru taluk recorded the highest disease intensity, with a mean incidence of 30.79% and a prevalence of 45.53%. The pathogen was isolated from infected tomato plants, and morphological identification revealed the characteristic sclerotia of S. rolfsii. Pathogenicity tests confirmed the fungus as the causative agent by reproducing typical symptoms on healthy tomato seedlings. Further molecular characterization of the internal transcribed spacer (ITS) region of the fungus confirmed its identity with high sequence similarity to known S. rolfsii strains in GenBank.
Conclusion: These findings underscore the urgent need for targeted disease management strategies to mitigate the spread of southern blight and protect tomato production in the Mysuru region, safeguarding both local and global food security.
Η αλλαγή στην οικονομική διακυβέρνηση της ΕΕ κατά την περίοδο της πανδημίας του COVID – 19 μέσα από την προσέγγιση του Ιστορικού Θεσμισμού
Authors: Ρούσσου Στυλιανή 
Published: July 2023

Η ΕΕ το 2020 έπρεπε να αντιμετωπίσει τις πολυδιάστατες επιπτώσεις της πανδημίας του COVID-19, ενώ σε κάθε κράτος - μέλος ότι οι προτεινόμενες μέθοδοι αντιμετώπισης της πανδημίας διέφεραν ανάλογα με το κοινωνικό, οικονομικό και πολιτικό πλαίσιο κάθε χώρας. Οι οικονομικές επιπτώσεις και το μέγεθος αυτών κατέστησαν απαραίτητη μια συλλογική απάντηση της ΕΕ σε υπερεθνικό επίπεδο για τη σύνθεση των διαφόρων τάσεων και αντιλήψεων, σε συνδυασμό με την αρχιτεκτονική της οικονομικής διακυβέρνησης της ΕΕ, προκειμένου να ξεπεραστεί η κατάσταση. Όπως κάθε κρίση, έτσι και αυτή της πανδημίας του COVID – 19, έχει την ικανότητα να εξελίσσει αυτούς που τη διαχειρίζονται. Στην περίπτωση αυτή, στ παρόν άρθρο εξετάζεται μέσα από την προσέγγιση του θεσμισμού η εξέλιξη της οικονομικής διακυβέρνησης της ΕΕ και πώς διαμορφώνει τη νέα οικονομική κατάσταση της Ευρώπης.

Λέξεις-κλειδιά: Ευρωπαϊκή Οικονομική Διακυβέρνηση, Οικονομική Κρίση, Πανδημία COVID-19, Ευρωπαϊκή Ολοκλήρωση, Θεσμισμός.
The Concept of Moral Education for Children According to Kitab Tarbiyatul Aulad
Authors: Hidayah Muhammad Nuur 
Published: July 2023

The study aims to describe the concept of moral education in children according to the book tarbiyatul aulad from Abdullah Nashih Ulwan as a guide in educating children in the present day that moral decline has taken place. This study is of literature research by collecting and analyzing the data sources of the various books, journals and documents relating to the educational thought of abdullah nashih ulwan. The study congcluded that material of moral education that abdullah nashih ulwan offers, that are, the moral education in the family and in the environment. In teaching morals, Abdullah Nashih Ulwan provided several methods such as teaching, habituation, punishment and reward and also giving good advice.
Levelling up or left behind? Does increasing GP training numbers inadvertently widen health inequalities?
Authors: Butler Daniel 
Published: July 2023

BackgroundIncreasing the GP workforce will not automatically level up healthcare provision; instead, increasing GP training numbers could worsen health inequity and inequalities. This is especially of concern if there are fewer opportunities to learn, train, and build confidence in under-served, socioeconomically deprived areas.AimTo examine how representative of wider socioeconomic deprivation the postgraduate GP training practices are in Northern Ireland (NI).MethodThe deprivation indices and scores of GP postgraduate training practices were compared against general practice in NI. Representation of practices whose patients live in blanket deprivation, higher deprivation, and higher affluence was compared.ResultsOf 319 practices in NI, 171 (54%) were registered as postgraduate training practices and had a mean deprivation score of 3.02 (95% CI [confidence interval] = 2.91 to 3.12) compared with non-training practices’ higher mean deprivation score of 3.2 (95% CI = 3.01 to 3.33),P-value <0.05. The proportion of training practices with blanket deprivation and higher levels of deprivation are marginally underrepresented and training practices had higher affluence scores.ConclusionPostgraduate training practices had a statistically significant lower deprivation score and did not fully reflect the socioeconomic make-up of wider NI general practice. The results, however, are more favourable than the representation in other areas of the UK and better than undergraduate teaching opportunities in general practice. As GP recruitment is increased, representation of general practice in areas of high need and high socioeconomic deprivation is essential, otherwise it risks widening health inequalities.
Có Một Lẽ Sống Tự Ngàn Xưa - Một Lối Nhìn về Con Người trong Tư Tưởng của Origen
Authors: Nguyễn Hữu Phong 
Published: July 2023

Lẽ sống là nguyên lý mà con người phải sống theo để được hạnh phúc. Origen quan niệm vạn vật có hai bản chất: bản chất hữu hình và bản chất vô hình, ứng với lẽ sống của thân và của tâm. Với bộ não của một triết gia cần mẫn và con tim của một tín hữu sùng đạo, Origen dường như đã tìm kiếm và tìm thấy lẽ sống tối hậu cho riêng mình. Dù xem mọi tạo vật là tốt đẹp nhưng Origen cũng tìm ra một trật tự khác dẫn con người đến sự sống thật. Đó là trật tự của Thân-Tâm-Chúa nơi nội tâm con người: Lẽ sống của thân phải phục vụ của tâm, và lẽ sống của tâm phải phục vụ Thiên Chúa. Nghĩa là, đòi hỏi của thân xác phải tùng phục những giá trị của tinh thần; và giá trị tinh thần tối hậu là phải hướng đến việc phục vụ Hóa Công; và việc phục vụ Hóa Công đạt đến viên mãn khi con người để lý trí của mình được soi sáng bởi Kinh Thánh và để ý chí tự do của mình tùng phục hoàn toàn vào Đức Ki-tô được mặc khải nơi Thánh Kinh. Lẽ sống này không chỉ ích lợi cho riêng Origen, mà, theo thiển ý của người viết, còn ích lợi cho con người mọi thời, thuộc mọi tôn giáo.

Abstract
The principle of life is what humans must live by in order to achieve happiness. Origen believed that everything has two natures: a tangible nature and an intangible nature, corresponding to the life principles of the body and the mind. With the mind of a philosopher and the heart of a devout believer, Origen seemed to search for and find the ultimate principle of life for himself. Although he regarded all creatures as good, Origen also discovered a different order that leads humans to true life. It is the order of Body-Mind-God within the inner being of humans: The life principle of the body must serve the mind, and the life principle of the mind must serve God. This means that the demands of the physical body must conform to the values of the spirit, and the ultimate value of the spirit is to serve the Divine Work; and serving the Divine Work is fulfilled when human beings enlighten their intellect with the Bible and completely surrender their free will to Christ revealed in the Holy Scriptures. This principle of life is not only beneficial for Origen himself but, according to the intention of the author, also beneficial for all people of all times and religions.
CRISPR/Cas9-mediated disruption of CjACOS5 confers no-pollen formation on sugi trees (Cryptomeria japonica D. Don)
Authors: Nishiguchi Mitsuru , Futamura Norihiro , Endo Masaki , Mikami Masafumi , Toki Seiichi , Katahata Shin-Ichiro , Ohmiya Yasunori , Konagaya Ken-ichi , Nanasato Yoshihiko , Taniguchi Toru , Maruyama Tsuyoshi Emilio 
Published: July 2023

AbstractSugi (Cryptomeria japonica D. Don) is an economically important coniferous tree in Japan. However, abundant sugi pollen grains are dispersed and transported by the wind each spring and cause a severe pollen allergy syndrome (Japanese cedar pollinosis). The use of pollen-free sugi that cannot produce pollen has been thought as a countermeasure to Japanese cedar pollinosis. The sugi CjACOS5 gene is an ortholog of Arabidopsis ACOS5 and rice OsACOS12, which encode an acyl-CoA synthetase that is involved in the synthesis of sporopollenin in pollen walls. To generate pollen-free sugi, we mutated CjACOS5 using the CRISPR/Cas9 system. As a result of sugi transformation mediated by Agrobacterium tumefaciens harboring the CjACOS5-targeted CRISPR/Cas9 vector, 1 bp-deleted homo biallelic mutant lines were obtained. Chimeric mutant lines harboring both mutant and wild-type CjACOS5 genes were also generated. The homo biallelic mutant lines had no-pollen in male strobili, whereas chimeric mutant lines had male strobili with or without pollen grains. Our results suggest that CjACOS5 is essential for the production of pollen in sugi and that its disruption is useful for the generation of pollen-free sugi. In addition to conventional transgenic technology, genome editing technology, including CRISPR/Cas9, can confer new traits on sugi.
Affinity-selected heparan sulfate collagen device promotes periodontal regeneration in an intrabony defect model in Macaca fascicularis
Authors: Luo Xiaoman , Lau Chau Sang , Le Bach Quang , Tan Tuan Chun , Too Jian Hui , Smith Raymond Alexander Alfred , Yu Na , Cool Simon M. 
Published: July 2023

AbstractIt is challenging to regenerate periodontal tissues fully. We have previously reported a heparan sulfate variant with enhanced affinity for bone morphogenetic protein-2, termed HS3, that enhanced periodontal tissue regeneration in a rodent model. Here we seek to transition this work closer to the clinic and investigate the efficacy of the combination HS3 collagen device in a non-human primate (NHP) periodontitis model. Wire-induced periodontitis was generated in ten Macaca fascicularis, and defects were treated with Emdogain or collagen (CollaPlug) loaded with (1) distilled water, (2) HS low (36 µg of HS3), or (3) HS high (180 µg of HS3) for 3 months. At the endpoint, microscopic assessment showed significantly less epithelial down-growth, greater alveolar bone filling, and enhanced cementum and periodontal ligament regeneration following treatment with the HS-collagen combination devices. When evaluated using a periodontal regeneration assessment score (PRAS) on a scale of 0–16, collagen scored 6.78 (± 2.64), Emdogain scored 10.50 (± 1.73) and HS low scored 10.40 (± 1.82). Notably, treatment with HS high scored 12.27 (± 2.20), while healthy control scored 14.80 (± 1.15). This study highlights the efficacy of an HS-collagen device for periodontal regeneration in a clinically relevant NHP periodontitis model and warrants its application in clinical trials.
Mucinous cystadenocarcinoma of the ovary in a 14-year-old girl: a case report and literature review
Authors: Li Qiong , Zou Cancan , Xu Yangyang , Liu Shiqing , Yan Tianjing 
Published: July 2023

Abstract
Background
Ovarian epithelial tumors are common in adults, and their peak incidence of onset is over 40 years of age. In children, most ovarian tumors are germ cell-derived, whereas epithelial tumors are rare and mostly benign.

Case presentation
This report describes a case of a 14-year-old Chinese girl with ovarian mucinous cystadenocarcinoma. She was admitted with a small amount of bloody vaginal discharge during the past month. Magnetic resonance imaging of the abdomen and pelvis showed a large solid cystic mass lesion in the left ovary. Tumor marker levels were within normal limits ( CA-125: 22.3 U/mL, HE4: 28.5 pmol/L, HCG: < 1.20 mIU/ml, AFP: 3.3 ng/ml, CEA: 2.2 ng/ml, CA19-9: < 2.0 U/mL). Laparoscopic exploration revealed a large left ovarian tumor. The patient underwent left salpingo-oophorectomy, and showed no significant issues during follow-up, as well as no evidence of recurrence or metastasis.

Conclusions
We report the first pediatric case of ovarian mucinous cystadenocarcinoma in China. Given the scarcity of reports addressing the clinical management of this condition, the present study provides a useful contribution to its further understanding in light of developing future treatment strategies.
KAN0438757: a novel PFKFB3 inhibitor that induces programmed cell death and suppresses cell migration in non-small cell lung carcinoma cells
Authors: Özdemir Deniz , Saruhan Seher , Ağca Can Ali 
Published: July 2023

Abstract
Background

PFKFB3 is glycolytic activators that is overexpressed in human lung cancer and plays a crucial role in multiple cellular functions including programmed cell death. Despite the many small molecules described as PFKFB3 inhibitors, some of them have shown disappointing results in vitro and in vivo. On the other hand KAN0438757, selective and potent, small molecule inhibitor has been developed. However, the effects of KAN0438757, in non-small cell lung carcinoma cells (NSCLCs) remain unknown. Herein, we sought to decipher the effect of KAN0438757 on proliferation, migration, DNA damage, and programmed cell death on NSCLCs.

Methods and Results

The effects of KAN0438757 on cell viability, proliferation, DNA damage, migration, apoptosis, and autophagy in human NSCLC cells was tested by WST-1, real-time cell analysis (RCTA), colony formation, comet assay, wound-healing migration test, and MMP/JC-1 and AO/ER dual staining assays as well as western blot analysis. Results revealed that KAN0438757 significantly suppressed the viability and proliferation of A549 and H1299 cells and inhibited colony formation and migration of A549 cells. More importantly, KAN0438757 caused DNA damage and triggered apoptosis and this was accompanied by the up-regulation of cleaved PARP in A549 cells. Furthermore, treatment with KAN0438757 resulted in increased LC3 II and Beclin1, which indicated that KAN0438757 stimulated autophagy.

Conclusions

Overall, targeting PFKFB3 with KAN0438757 may be a promising effective treatment approach, requiring further in vitro and in vivo evaluation of KAN0438757 as a therapy in NSCLCs.
KONSEP PENDIDIKAN AKHLAK PERSEPEKTIF IMAM AL-GHAZALI DAN AKTUALISASINYA PADA PENDIDIKAN ISLAM DI INDONESIA
Authors: Sanuhung Fitriyani , Ichsan Yazida , Setyaningrum Nur Rahma , Restianti Alif Fajar 
Published: July 2023

Abstract: The purpose of this study is to find out the concept of moral education proposed by Imam Al Ghazali and its relation to Islamic education in Indonesia and its contextualization of current Islamic education. Moral education is still often a topic that is discussed until now the phenomenon of criminal acts that occur in the community is a serious problem for the decline of people's morals. This research was conducted using the literature method by taking data from books, journals, and other websites. Moral education according to Imam Al Ghazali defines morals as one of the attitudes contained in humans and is the cause of the emergence of other behaviors, as easy that does not require prior planning The concept of Imam Al Ghazali's moral education is still relevant to be used today. Keywords. Character education, Imam Al Ghazali