bluuebunny/crossref_metadata_2025_split huggingface dataset:
Market-oriented solutions for groundwater commons through collective-action
Authors: Allen Jonah J , Smith Steven M 
Published: March 2023

Abstract
Groundwater scarcity poses threats to communities across the globe, and effectively managing those challenges requires designing policy that achieves institutional fit. Collective action is well-suited to match rules with local context, and multiple pathways exist for communities to achieve reductions in groundwater use. To better understand how local conditions influence rule design, we examine two groundwater-reliant communities in the Western US that engaged in collective-action to arrive at distinct groundwater management rules. We consider: what drove stakeholders in Northwestern Kansas (NWKS) and San Luis Valley, Colorado (SLV) to adopt local groundwater policies, and why were different management pathways chosen? Further, why is more heterogeneity observed between local management organizations in SLV as compared to NWKS? To investigate these questions, we employ grounded theory to interpret the rules in reference to local hydro-agro-economic statistics and interviews with stakeholders (n = 19) in each region selected by expert sampling. We find that the additional goals of groundwater rules in SLV, partially driven by key contrasts in the resource system compared to NWKS, and higher resource productivity in SLV, creates both the need for and efficacy of a price-centered policy. Furthermore, variation in the resource systems and associated farm characteristics between subdistricts drives higher heterogeneity in rule design between local management districts in SLV compared to NWKS. More generally, we find the local flexibility afforded through the collective-action process as critical, even if it were to arrive at alternative, non-economic based incentives.
Developing a Culturally Competent Neuropsychological Assessment Battery for Vietnamese-speaking Patients with Suspected Dementia
Authors: McCauley Stephen R , Nguyen Thomas , Nguyen Christopher , Strutt Adriana M , Stinson Jennifer M , Windham Victoria A , York Michele K 
Published: March 2023

Abstract

Objectives
To assemble a core battery of culturally and linguistically appropriate neuropsychological measures that can be administered to Vietnamese-speaking patients with suspected dementia.

Methods
Test instruments in Vietnamese were identified through systematic searches of PubMed, PsychInfo, and Google Scholar, and in consultation with two Vietnamese-speaking cultural brokers.

Results
A battery assessing the domains of attention, executive function, verbal and visual episodic memory, basic language abilities, visuospatial/visuoconstruction abilities, and mood/anxiety was assembled that included core measures developed either specifically for a Vietnamese-speaking population, or were validated/normed with a Vietnamese-speaking sample either in Vietnam or Vietnamese-speaking persons in the U.S. Supplemental measures were selected that can be administered using translated instructions with U.S. English normative data. The rationale for test selection and caveats for their clinical use are presented.

Conclusions
The number of neuropsychological measures identified in Vietnamese and/or with Vietnamese normative data was sparse. Given the large and growing population of Vietnamese-speaking residents in the U.S. and the aging of these communities, it is imperative to develop additional, appropriately designed and normed instruments to provide culturally competent assessments to better serve these individuals.
Silicone Migration From Breast Implants: A Case of Ocular Siliconoma and Literature Review
Authors: Montemurro Paolo , Pellegatta Tommaso , Burton Harry , Pafitanis Georgios 
Published: March 2023

Abstract

Background
Breast augmentation with implants is one of the most popular cosmetic surgery operations performed worldwide. Complications of breast implants are well recognized, and include capsular contracture, implant rupture, and infrequently distant migration of silicone, resulting in siliconoma. Distant migration of silicone can present many years after implantation with a wide variety of signs and symptoms.

Objectives
The aim of this study was to describe the authors’ experience of orbital silicone migration and to review the literature describing documented cases of distant silicon migration from breast implants, both ocular and nonocular.

Methods
In January 2022, a case of breast implant augmentation presented with silicone migration into the right orbit. This rare case was monitored and diagnosed with ocular muscle palsy and diplopia. Here, the authors present the patient's presenting complaint, symptomatology, working investigations, and outcomes. A comprehensive report of all available cases of distant silicone migration is presented along with their associated complications and more specifically ocular silicone migration.

Results
Systemic migration of silicone from breast implants to the orbital region is extremely rare: a total of 4 previous cases of ocular silicone migration from breast implants have been described previously; the authors describe the fifth case herein.

Conclusions
Silicone implant rupture can present with a wide variety of clinical symptoms that may mimic different clinical pathologies. In every patient with a history of breast augmentation with silicone implants, the possibility of silicone migration should be always taken into consideration during the differential diagnosis process.

Level of Evidence: 5
End-to-end interpretable disease–gene association prediction
Authors: Li Yang , Guo Zihou , Wang Keqi , Gao Xin , Wang Guohua 
Published: March 2023

Abstract
Identifying disease–gene associations is a fundamental and critical biomedical task towards understanding molecular mechanisms, the diagnosis and treatment of diseases. It is time-consuming and expensive to experimentally verify causal links between diseases and genes. Recently, deep learning methods have achieved tremendous success in identifying candidate genes for genetic diseases. The gene prediction problem can be modeled as a link prediction problem based on the features of nodes and edges of the gene–disease graph. However, most existing researches either build homogeneous networks based on one single data source or heterogeneous networks based on multi-source data, and artificially define meta-paths, so as to learn the network representation of diseases and genes. The former cannot make use of abundant multi-source heterogeneous information, while the latter needs domain knowledge and experience when defining meta-paths, and the accuracy of the model largely depends on the definition of meta-paths. To address the aforementioned challenges above bottlenecks, we propose an end-to-end disease–gene association prediction model with parallel graph transformer network (DGP-PGTN), which deeply integrates the heterogeneous information of diseases, genes, ontologies and phenotypes. DGP-PGTN can automatically and comprehensively capture the multiple latent interactions between diseases and genes, discover the causal relationship between them and is fully interpretable at the same time. We conduct comprehensive experiments and show that DGP-PGTN outperforms the state-of-the-art methods significantly on the task of disease–gene association prediction. Furthermore, DGP-PGTN can automatically learn the implicit relationship between diseases and genes without manually defining meta paths.
Inflammatory Bowel Disease and Risk of Colorectal Polyps: A Nationwide Population-Based Cohort Study From Sweden
Authors: Axelrad Jordan E , Olén Ola , Söderling Jonas , Roelstraete Bjorn , Khalili Hamed , Song Mingyang , Faye Adam , Eberhardson Michael , Halfvarson Jonas , Ludvigsson Jonas F 
Published: March 2023

Abstract

Background
Inflammatory bowel disease [IBD] has been linked to an increased risk of colorectal neoplasia. However, the types and risks of specific polyp types in IBD are less clear.

Methods
We identified 41 880 individuals with IBD (Crohn’s disease [CD: n = 12 850]; ulcerative colitis [UC]: n = 29 030]) from Sweden matched with 41 880 reference individuals. Using Cox regression, we calculated adjusted hazard ratios [aHRs] for neoplastic colorectal polyps [tubular, serrated/sessile, advanced and villous] defined by histopathology codes.

Results
During follow-up, 1648 [3.9%] IBD patients and 1143 [2.7%] reference individuals had an incident neoplastic colorectal polyp, corresponding to an incidence rate of 46.1 and 34.2 per 10 000 person-years, respectively. This correlated to an aHR of 1.23 (95% confidence interval [CI] 1.12–1.35) with the highest HRs seen for sessile serrated polyps [8.50, 95% CI 1.10–65.90] and traditional serrated adenomas [1.72, 95% CI 1.02–2.91]. aHRs for colorectal polyps were particularly elevated in those diagnosed with IBD at a young age and at 10 years after diagnosis. Both absolute and relative risks of colorectal polyps were higher in UC than in CD [aHRs 1.31 vs 1.06, respectively], with a 20-year cumulative risk difference of 4.4% in UC and 1.5% in CD, corresponding to one extra polyp in 23 patients with UC and one in 67 CD patients during the first 20 years after IBD diagnosis.

Conclusions
In this nationwide population-based study, there was an increased risk of neoplastic colorectal polyps in IBD patients. Colonoscopic surveillance in IBD appears important, especially in UC and after 10 years of disease.
Ecophysiological responses of individually and group reared Cydalima perspectalis (Lepidoptera: Crambidae) to alkaloid-containing host plants
Authors: Kholghahmadi Maryam , Karimi-Malati Azadeh , Jalali Sendi Jalal 
Published: March 2023

Abstract
The box tree moth, Cydalima perspectalis (Walker), is an invasive pest of Hyrcanian forests in Iran. In the current study, the effects of two boxwood species, Buxus hyrcana Pojark and B. microphylla Sieb. and Zucc. (Buxales: Buxaceae), were examined on ecophysiology of the pest. The demographic parameters were evaluated based on the age-stage, two-sex life table theory. The physiological characteristics of C. perspectalis were considered through fresh/dry weights and individually/group rearing methods. The results showed that C. perspectalis larvae were able to develop, survive and reproduce on both boxwood species. The developmental times were 41.62 and 41.46 days on B. hyrcana and B. microphylla, respectively. The total lifespan did not differ on boxwood species. However, the difference of fecundity on B. hyrcana (412.82 eggs/female) and B. microphylla (286.06 eggs/female) was significant. The intrinsic rate of increase (r) and finite rate of increase (λ) were significantly higher on B. hyrcana than B. microphylla. The nutritional indices showed that the consumption index (CI) on B. hyrcana were significantly lower than on B. microphylla based on fresh/dry weights in both rearing methods. Conversely, the efficiency of conversion of digested food (ECD) and the efficiency of conversion of ingested food (ECI) on B. hyrcana were significantly higher than on B. microphylla. Despite nonsignificant differences in leaf nutrient contents (except calcium), total protein, triglyceride, and alkaline phosphatase activity were inversely different in larvae compared to adult stage on boxwood species. These findings could help to comprehensively understand the performance of the pest on boxwood species.
Reversal and removal of oral antithrombotic drugs in patients with active or perceived imminent bleeding
Authors: Cao Davide , Amabile Nicolas , Chiarito Mauro , Lee Victoria T , Angiolillo Dominick J , Capodanno Davide , Bhatt Deepak L , Mack Michael J , Storey Robert F , Schmoeckel Michael , Gibson C Michael , Deliargyris Efthymios N , Mehran Roxana 
Published: March 2023

Abstract
Remarkable progress has been made in the pharmacological management of patients with cardiovascular disease, including the frequent use of antithrombotic agents. Nonetheless, bleeding complications remain frequent and potentially life-threatening. Therapeutic interventions relying on prompt antithrombotic drug reversal or removal have been developed to assist clinicians in treating patients with active bleeding or an imminent threat of major bleeding due to urgent surgery or invasive procedures. Early phase studies on these novel strategies have shown promising results using surrogate pharmacodynamic endpoints. However, the benefit of reversing/removing antiplatelet or anticoagulant drugs should always be weighed against the possible prothrombotic effects associated with withdrawal of antithrombotic protection, bleeding, and surgical trauma. Understanding the ischemic-bleeding risk tradeoff of antithrombotic drug reversal and removal strategies in the context of urgent high-risk settings requires dedicated clinical investigations, but challenges in trial design remain, with relevant practical, financial, and ethical implications.
How to tuna fish: constraint, convergence, and integration in the neurocranium of pelagiarian fishes
Authors: Knapp Andrew , Rangel-de Lázaro Gizéh , Friedman Matt , Johanson Zerina , Evans Kory M , Giles Sam , Beckett Hermione T , Goswami Anjali 
Published: March 2023

Abstract
Morphological evolution of the vertebrate skull has been explored across a wide range of tetrapod clades using geometric morphometrics, but the application of these methods to teleost fishes, accounting for roughly half of all vertebrate species, has been limited. Here we present the results of a study investigating 3D morphological evolution of the neurocranium across 114 species of Pelagiaria, a diverse clade of open-ocean teleost fishes that includes tuna and mackerel. Despite showing high shape disparity overall, taxa from all families fall into three distinct morphological clusters. Convergence in shape within clusters is high, and phylogenetic signal in shape data is significant but low. Neurocranium shape is significantly correlated with body elongation and significantly but weakly correlated with size. Diet and habitat depth are weakly correlated with shape, and nonsignificant after accounting for phylogeny. Evolutionary integration in the neurocranium is high, suggesting that convergence in skull shape and the evolution of extreme morphologies are associated with the correlated evolution of neurocranial elements. These results suggest that shape evolution in the pelagiarian neurocranium reflects the extremes in elongation found in body shape but is constrained along relatively few axes of variation, resulting in repeated evolution toward a restricted range of morphologies.
Sperm-contributed centrioles segregate stochastically into blastomeres of 4-cell stage Caenorhabditis elegans embryos
Authors: Gönczy Pierre , Balestra Fernando R 
Published: March 2023

Abstract
Whereas both sperm and egg contribute nuclear genetic material to the zygote in metazoan organisms, the inheritance of other cellular constituents is unequal between the 2 gametes. Thus, 2 copies of the centriole are contributed solely by the sperm to the zygote in most species. Centrioles can have a stereotyped distribution in some asymmetric divisions, but whether sperm-contributed centrioles are distributed in a stereotyped manner in the resulting embryo is not known. Here, we address this question in Caenorhabditis elegans using marked mating experiments, whereby the presence of the 2 sperm-contributed centrioles is monitored in the embryo using the stable centriolar component SAS-4::GFP, as well as GFP::SAS-7. Our analysis demonstrates that the distribution of sperm-contributed centrioles is stochastic in 4-cell stage embryos. Moreover, using sperm from zyg-1 mutant males that harbor a single centriole, we show that the older sperm-contributed centriole is likewise distributed stochastically in the resulting embryo. Overall, we conclude that, in contrast to the situation during some asymmetric cell divisions, centrioles contributed by the male germ line are distributed stochastically in embryos of C. elegans.
The emergence of Leveller polemic: William Walwyn, collaborative authorship and radical identity, 1645–7
Authors: De Krey Gary S 
Published: March 2023

Abstract
This article investigates Leveller prehistory by analysing three polemical tracts of 1646–7. William Walwyn and Richard Overton arguably collaborated in the Remonstrance of Many Thousand Citizens and in the New Found Stratagem Framed in the Old Forge of Machivilisme, as well as in the Warning to All the Counties of England. Their denunciations of the dominant Presbyterian faction supported the independent alliance; but they employed distinctive language too extreme for many independents, pointing to their increasing political ambiguity. Their collaboration challenges scholarly characterizations of Walwyn’s ‘gentle’ style. The essay concludes by examining the related emergence of London, army and county radicals, some of whom would soon become Levellers.
Characterization of “Off-Target” Immune Modulation Induced by Live Attenuated Yellow Fever Vaccine
Authors: Xiang J , Chang Q , McLinden J H , Bhattarai N , Welch J L , Kaufman T M , Stapleton Jack T 
Published: March 2023

Abstract

Background
Live attenuated vaccines alter immune functions and are associated with beneficial outcomes. We previously demonstrated that live attenuated yellow fever virus (YFV) vaccine (LA-YF-Vax) dampens T-cell receptor (TCR) signaling in vitro via an RNA-based mechanism. We examined study participants before and after LA-YF-Vax to assess TCR-mediated functions in vivo.

Methods
Serum samples and peripheral blood mononuclear cells (PBMCs) were obtained before and after LA-YF-Vax (with or without additional vaccines) or quadrivalent influenza vaccine. TCR-mediated activation was determined by interleukin 2 release or phosphorylation of the lymphocyte-specific Src kinase. TCR-regulating phosphatase (protein tyrosine phosphatase receptor type E [PTPRE]) expression was also measured.

Results
Compared with prevaccination findings, LA-YF-Vax recipient PBMCs demonstrated transient reduction in interleukin 2 release after TCR stimulation and PTPRE levels, unlike in control participants who received quadrivalent influenza vaccine. YFV was detected in 8 of 14 participants after LA-YF-Vax. After incubation of healthy donor PBMCs in serum-derived extracellular vesicles prepared from LA-YF-Vax recipients, TCR signaling and PTPRE levels were reduced after vaccination, even in participants without detectable YFV RNA.

Conclusions
LA-YF-Vax reduces TCR functions and PTPRE levels after vaccination. Extracellular vesicles from serum recapitulated this effect in healthy cells. This likely contributes to the reduced immunogenicity for heterologous vaccines after LA-YF-Vax administration. Identification of specific immune mechanisms related to vaccines should contribute to understanding of the “off-target,” beneficial effects of live vaccines.
Blood transcriptome of Rasa Aragonesa rams with different sexual behavior phenotype reveals CRYL1 and SORCS2 as genes associated with this trait
Authors: Lakhssassi Kenza , Sarto María Pilar , Lahoz Belén , Alabart José Luis , Folch José , Serrano Malena , Calvo Jorge Hugo 
Published: March 2023

Abstract
Reproductive fitness of rams is seasonal, showing the highest libido during short days coinciding with the ovarian cyclicity resumption in the ewe. However, the remarkable variation in sexual behavior between rams impair farm efficiency and profitability. Intending to identify in vivo sexual behavior biomarkers that may aid farmers to select active rams, transcriptome profiling of blood was carried out by analyzing samples from 6 sexually active (A) and 6 nonactive (NA) Rasa Aragonesa rams using RNA-Seq technique. A total of 14,078 genes were expressed in blood but only four genes were differentially expressed (FDR &lt; 0.10) in the A vs. NA rams comparison. The genes, acrosin inhibitor 1 (ENSOARG00020023278) and SORCS2, were upregulated (log2FC &gt; 1) in active rams, whereas the CRYL1 and immunoglobulin lambda-1 light chain isoform X47 (ENSOARG00020025518) genes were downregulated (log2FC &lt; -1) in this same group. Gene set Enrichment Analysis (GSEA) identified 428 signaling pathways, predominantly related to biological processes. The lysosome pathway (GO:0005764) was the most enriched, and may affect fertility and sexual behavior, given the crucial role played by lysosomes in steroidogenesis, being the SORCS2 gene related to this signaling pathway. Furthermore, the enriched positive regulation of ERK1 and ERK2 cascade (GO:0070374) pathway is associated with reproductive phenotypes such as fertility via modulation of hypothalamic regulation and GnRH-mediated production of pituitary gonadotropins. Furthermore, external side of plasma membrane (GO:0009897), fibrillar center (GO:0001650), focal adhesion (GO:0005925), and lamellipodium (GO:0030027) pathways were also enriched, suggesting that some molecules of these pathways might also be involved in rams’ sexual behavior. These results provide new clues for understanding the molecular regulation of sexual behavior in rams. Further investigations will be needed to confirm the functions of SORCS2 and CRYL1 in relation to sexual behavior.
Xylella fastidiosa inoculation behaviors (EPG X wave) are performed differently by blue-green sharpshooters based on infection status of prior probing host
Authors: Roddee Jariya , Backus Elaine A , Cervantes Felix A , Hanboonsong Yupa 
Published: March 2023

Abstract
Does Xylella fastidiosa, a bacterial plant pathogen with noncirculative foregut-borne transmission, manipulate behavior of its sharpshooter vector to facilitate its own inoculation? To answer this question, blue-green sharpshooters, Graphocephala atropunctata (Signoret), were reared on basil to clean their foreguts, then removed from the colony and given one of four pre-electropenetrography (EPG) treatments: i) old colony adults on basil, ii) young colony adults on basil, iii) young colony adults held on healthy grapevine for 4 days, and iv) young colony adults held on Xf-infected (symptomatic) grapevine for 4 days. After treatments, stylet probing behaviors were recorded on healthy grapevine via AC-DC electropenetrography. Waveforms representing putative Xf inoculation (XB1 [salivation and rinsing egestion] and XC1 [discharging egestion]) and other behaviors were statistically compared among treatments. Mean number of events per insect and ‘total’ duration per insect of XB1 and XC1 were highest for insects from healthy grape, lowest for basil (regardless of insect age), and intermediate for Xf-infected grape. The surprising results showed that prior exposure to healthy grapevines had a stronger effect on subsequent performance of inoculation behaviors on healthy grapevine than did prior exposure to Xf-infected grapevine. It is hypothesized that non-Xf microbes were acquired from healthy grapevine, causing greater clogging of the precibarium, leading to more performance of inoculation behaviors. This study shows for the first time that presence of noncirculative, foregut-borne microbes can directly manipulate a vector’s behavior to increase inoculation. Also, EPG can uniquely visualize the dynamic interactions between vectors and the microbes they carry.