bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vaca Muerta Corrosiveness and Its Impact in Production Strategy
Authors: Gawantka da Silva Lelio Alberto , Toro Padilla Roberto , Molina Mariano Sebastián , Benedetto Claudio Fabián , Olivo Pedro , Mazzina Ramiro 
Published: March 2023

AbstractThe complexity of the problem and the severity of corrosion found at certain fields of shale gas in Vaca Muerta made necessary to develop a program that included predictive analysis through semi-empirical corrosion-erosion models, comparison of materials through the installation of coupons in downhole wells and, finally, the execution of several pilots in the field under real operating conditions. On top of this, an exhaustive monitoring of the physical-chemical conditions of the fluids and the performance of the analyzed materials was executed.The corrosion problem associated with the development of Vaca Muerta is extremely complex. Aggressive agents such as CO2 were observed in a wide range of quantities, accompanied by a high concentration of chlorides in the flow-back water together with high initial flows and the presence of a high concentration of sand of fracture (proppant) in the early stage of the well. The combination of these agents presupposes a risky scenario for some tubular materials.Therefore, to limit the probability of failure and ensure the integrity of the installations during the production life, a coupon evaluation program was carried out in the field with alloys containing 3% and 13% Cr, accompanied by predictive analysis, loss of thickness in pipe through different models known in the industry. Finally, a pilot program has been executed at the field, monitoring the pipes with successive multi-fingers calipers to determine the impact of corrosion on the materials.The conclusion of this entire process made it possible to establish a production strategy that minimizes the risk of failure due to corrosion and contributes to the integrity of the downhole installations during their service life, minimizing interventions and ensuring the operational continuity of the well.All this process is going to be presented at this work, detailing the engineering process prior to propose an alternative to mitigate the problem from the joint vision of an operator in the region and a tubular manufacturer.
Fatty acid synthesis suppresses dietary polyunsaturated fatty acid use
Authors: Worthmann Anna , Ridder Julius , Piel Sharlaine , Evangelakos Ioannis , Musfeldt Melina , Voß Hannah , O'Farell Marie , Fischer Alexander , Adak Sangeeta , Sundd Monica , Siffeti Hasibullah , Haumann Friederike , Kloth Katja , Bierhals Tatjana , Heine Markus , Pertzborn Paul , Pauly Mira , Scholz Julia-Josefine , Kundu Suman , Fuh Manka , Neu Axel , Tödter Klaus , Hempel Maja , Knippschild Uwe , Semenkovich Clay , Schlüter Hartmut , Heeren Joerg , Scheja Ludger , Kubisch Christian , Schlein Christian 
Published: March 2023

Abstract
Metabolic diseases are closely linked to aberrant synthesis of endogenous fatty acids in the liver, called de novo lipogenesis (DNL), which is mediated by the enzyme fatty acid synthase (FASN). The composition of complex lipids consists of saturated or monosaturated fatty acids, which can be endogenously produced, and polyunsaturated fatty acids (PUFA), which are strictly dietary. Compositional differences between individuals are insufficiently understood and may influence the onset and progression of metabolic and cardiovascular diseases. Here we show that DNL critically determines the use of dietary PUFA. A patient with a hypofunctional heterozygous de novo Arg2177Cys variant in FASN exhibited an elevated composition of PUFA, which was phenocopied by pharmacological inhibition of FASN with TVB-2640 in patients with nonalcoholic steatohepatitis (NASH). In mice, the incorporation rate of supplemented omega-3 PUFA during an obesogenic diet was increased by genetic or pharmacologic reduction of DNL. Mechanistically, we show that the FASN variant exhibited a cysteine-dependent, non-enzymatic acetylation of FASN, which resulted in hyperubiquitinylation and decreased protein stability. The study reveals that PUFA storage is an active, enzymatic process controlled by FASN, DGAT2 and MFSD2A and that combining FASN inhibition and PUFA supplementation exerts additive beneficial metabolic effects. These findings provide evidence that the success of PUFA supplementation may depend on the rate of endogenous DNL and that combined PUFA supplementation and FASN inhibition may be a promising approach in metabolic disease.
A New Detection Jamming Attack Model on VANET Ad hoc Networks
Authors: Obeidat Ibrahim , Mughaid Ala , Alofishat Osama 
Published: March 2023

Abstract
Research on Vehicular Ad hoc Networks (VANET) has been the main attractive Research effort these days, a vehicular ad hoc network (VANET) is an extension of a mobile ad hoc network (MANET), where vehicles can communicate with each other in a form of the intelligent transport system (ITS). The communication between vehicles can be interfered with by Denial of Service (DoS) attacks such as jamming attacks, launching on the control channel, and causing significant network performance degradation. These attacks have an impact on the network by lowering network performance; earlier, there has been a lot of study for improving network performance by employing routing protocols. When a jammer can interpret data link layer protocols, it becomes as energy efficient as legitimate nodes. In this Research, we have built a model that examines the performance of vehicular ad hoc networks (VANET) under jamming attacks to provide EVA(Enhancement Voting Algorithm) based on global Trust( Direct Trust and Indirect Trust)for detecting jamming attacks. Route request (RREQ), and route reply (RPLY) packets are utilized in the route discovery phase. In the route maintenance phase, Route Error (RERR) and HELLO packets are used. These packets are also measured while assessing trust because they contribute significantly to routing activities. Although misbehaving nodes can handle those packets, their likelihood of being used is lower than that of well-behaving nodes. Three trust levels are defined based on the computed global trust value to make the best routing decision, which will be implemented in NS3 simulation. We use Bonnmotion to create and analyze mobility scenarios, which serve as a tool for investigating mobile multi-hop network scenario characteristics. The scenarios were exported for the network simulators NS3 to create a mechanism approach. The network's performance is evaluated in terms of QoS parameters and throughput (PDR), signal intensity, RSSI, carrier sensing time, energy consumption, average delay, and throughput to identify network performance under jamming attacks. It is examined that after malicious nodes which send data above the assigned value have been labeled as malicious nodes and removed from the network, the network performance significant Improvement.
Telehealth-supported exercise/physical activity programs for knee osteoarthritis: A systematic review and meta-analysis
Authors: HE Chengqi , Xiang Xiao-Na , Wang Ze-Zhang , Zhang Jiang-Yin , Li Ke , Chen Qi-Xu , Xu Fa-Shu , Zhang Yue-Wen , He Hong-Chen , Zhu Si-Yi 
Published: March 2023

Abstract
The integration of telehealth-supported programs in chronic disease management has become more common, but it is unclear if this approach is effective for individuals with knee osteoarthritis. This study aimed to assess the effectiveness of telehealth-supported exercise/physical activity programs in individuals with knee osteoarthritis. A comprehensive literature search was conducted in September 2022 on randomized controlled trials compared telehealth-supported exercise/physical activity programs to a control condition for knee osteoarthritis. Twenty-three studies met eligibility criteria, of which 20 studies included in the meta-analysis. The results showed that telehealth-supported exercise/physical activity programs reduced pain (g = − 0.39, CI − 0.67 to − 0.11, I2 = 83%), improved physical activity (g = 0.13, CI 0.03 to 0.23, I2 = 0%) and enhanced physical function (g = − 0.51, CI − 0.98 to − 0.05, I2 = 87%). In addition, better improvements in quality of life, self-efficacy for pain, and global improvement were observed, but self-efficacy for physical function showed insignificant improvements. The results indicate that a telehealth-supported exercise/physical activity program could be an effective treatment for knee osteoarthritis. Future research should consider longer implementation durations and the feasibility of incorporating wearables and standardized components into large-scale interventions to evaluate the effects.
Activated carbon with high mesopore ratio derived from waste Zanthoxylum bungeanum branches by KNO3 assisted H3PO4 staged activation for toluene adsorption
Authors: Xie Hongmei , Liu Na , Wang Haoyu , Chen Shuang , Zeng Jia , Zhou Guilin 
Published: March 2023

Abstract
Waste Zanthoxylum bungeanum branches were used to prepare activated carbon adsorbents with high mesopore ratio by H3PO4 staged activation method with adding KNO3 additive. The prepared activated carbon adsorbents were characterized by SEM, BET, FT-IR, and XRD. The adsorption properties of the prepared activated carbon adsorbents were evaluated by the toluene adsorption/desorption in air. The quasi-first-order, quasi-second-order, and Bangham models were used to fit the obtained toluene adsorption results. The oxidative etching of KNO3 additive improved the pore-forming ability of the H3PO4 activator to enhance the activation pore-forming effects of the selected biomass raw material. The secondary pore-forming effects of K atoms promoted the effective expansion of the pore diameter in the activated carbon preparation process to prepare activated carbon adsorbents with high mesopore proportion. The specific surface area and mesopore proportion of the activated carbon adsorbents prepared by adding KNO3 additive exceeded 1100 m2/g and 71.0%, respectively, and the toluene adsorption capacity exceeded 370.0 mg/g. The rich mesopore structures can effectively reduce the toluene mass transfer resistance, which can promote the corresponding activated carbon adsorbent to be regenerated by low-temperature (40 °C) thermal desorption. The toluene adsorption on the prepared activated carbon adsorbents include surface adsorption and diffusion in pore strucutres, and the toluene adsorption mechanism is more consistent with the Bangham kinetic model.
Improved structure of Zr-BTC metal organic framework using NH 2 to enhance CO 2 adsorption performance
Authors: Esfahani Heidar Javdani , Shahhosseini Shahrokh , Ghaemi Ahad 
Published: March 2023

Abstract
Modified mesoporous NH2-Zr-BTC mixed ligand MOF nanocomposites were synthesized via the hydrothermal method as a novel adsorbent for CO2 capture. The newly modified MOF-808 with NH2 demonstrated a similar mesoporous morphology as MOF-808, whereas the specific surface area, pore volume, and average particle size, respectively, increased by 15%, 6%, and 46% compared to those of MOF-808. The characterization analyses exhibited the formation of more active groups on the adsorbent surface after modification. In addition, a laboratory adsorption setup was used to evaluate the effect of temperature, pressure, and NH2 content on the CO2 adsorption capacity in the range of 25-65 °C, 1-9 bar, and 0-20 wt%, respectively. An increase in pressure and a decrease in temperature enhanced the adsorption capacity. The highest equilibrium adsorption capacity of 369.11 mg/g was achieved at 25°C, 9 bar, and 20wt% NH2. By adding 20wt% NH2, the maximum adsorption capacity calculated by the Langmuir model increased by about 4% compared to that of pure MOF-808. Moreover, Ritchie second-order and Sips models were the best-fitted models to predict the kinetics and isotherm data of CO2 adsorption capacity with the high correlation coefficient (R2> 0.99) and AARE% of less than 0.1. The DH°, DS°, and DG° values were -17.360 kJ/mol, -0.028 kJ/mol K, and -8.975 kJ/mol, respectively, demonstrating a spontaneous, exothermic, and physical adsorption process. Furthermore, the capacity of MH-20% sample decreased from 279.05 to 257.56 mg/g after 15 cycles, verifying excellent stability of the prepared mix-ligand MOF sorbent.
Research on Polishing Mechanisms of Various Surfactants in Chemical Mechanical Polishing Relevant to Cobalt Interconnects
Authors: Zhang Lifei , Wang Shuhui , Wang Tongqing , Lu Xinchun 
Published: March 2023

Abstract
Cobalt (Co) with its low resistivity, superior adhesion property, and void-free seamless fill ability, is being considered by the industry as a promising candidate to replace the conventional tungsten contact plugs for middle-of-the-line and the wiring metal copper interconnects for back-end-of-the-line. Chemical mechanical polishing (CMP), whose demand is greatly increasing as device dimensions shrink to 7 nm node, has been recognized as one of the indispensable manufacturing approaches for the fabrication of multilevel metal interconnection structures. This work investigates the optimization process of the final CMP step for Co interconnects by introducing surfactants in hydrogen peroxide based slurries. Various types of surfactants having different functional groups were employed and compared thoroughly by material removal rates (MRRs) and selectivity. The chemical and mechanical mechanisms of various surfactants during CMP process have been clearly revealed by various approaches, including polishing and static etching experiments, electrochemical analysis, tests of absolute zeta potentials and particle sizes, as well as wafer surface energy measurements. Research results show that Co MRRs are directly correlated with functional groups of various surfactants. Moreover, absolute zeta potentials of abrasive particles can be deeply influenced by different types of surfactants, where the correlation between absolute zeta potentials and Co MRRs presents strong negative. On the other hand, direct positive correlation between oxide MRRs and particle sizes affected by corresponding surfactants can be summarized. Meanwhile, no obvious corresponding relationship between contact angles and MRRs was found, indicating MRRs was barely affected by wettability of wafer surfaces. At last, the selected surfactants were applied to 12-inches-wafers for verification, including MRRs, removal selectivity, defects and surface roughness. Each of these surfactants could make Co and TEOS surface Ra maintain at around below 0.7 nm and 0.3 nm, with a number of residual particles lower than 600 particle/wafer.
Endogenous noise of neocortical neurons drives atypical sensory
response variability in autism
Authors: Bhaskaran Arjun , Gauvrit Théo , Vyas Yukti , Bony Guillaume , Ginger Melanie , Frick Andreas 
Published: March 2023

Abstract
Excessive trial-by-trial and inter-individual neural variability of sensory responses are hallmarks of atypical sensory processing in autistic individuals with cascading effects on other core autism symptoms. The neurobiological substrate of this exaggerated variability is unknown. Here, by recording neocortical single neuron activity in a well-established mouse model of autism, we characterized atypical sensory processing and probed the role of endogenous noise sources as a driver for response variability. The analysis of sensory stimulus evoked activity and spontaneous dynamics, as well as neuronal features, reveals a complex phenotype composed of both cellular and circuit alterations. Neocortical sensory information processing in autistic animals is more variable, unreliable, and temporally imprecise. This increased trial-by-trial and inter-neuronal response variability is strongly related with key endogenous noise features. We provide a novel preclinical framework for understanding the sources of endogenous noise and its contribution to core symptoms in autism, and for testing the functional consequences for mechanism-based manipulation of this noise.
Oral absorption-promoting of Panax notoginseng saponins-loaded Nanoparticles modified with Thiolated trimethyl chitosan and Wheat germ agglutinin
Authors: Fang Ruiyue , Zhao Ying , Lin Shiyuan , Wei Yue , Chen Hui 
Published: March 2023

Abstract
Traditional Chinese medicine (TCM) oral preparations is the main means of disease treatment in TCM clinically, but the bioavailability of TCM active ingredients such as panax noteginseng saponins (PNS) is low due to its poor intestinal absorption. In this study, PNS nanoparticle modified with thiolated trimethyl chitosan (TMC-Cys) and wheat germ agglutinin (WGA) (PP-WT NPs) was prepared to promote the oral absorption of PNS effectively. In vitro studies demonstrated that PP-WT NPs delayed the release of PNS and had strong anti-enzyme activities against acids and digestive enzymes in the gastrointestinal environment. And it has good cell uptake and transport capacity in the Caco-2/HT29 co-cultured cell model. In vivo animal experiments showed that PP-WT NPs could penetrate the mucus layer barrier, and the effective permeability coefficients for R1, Rg1, and Rb1 in the small intestine were 1.68, 1.64, and 1.63 times than that of free PNS, respectively. It was predicted that panax notoginseng saponins-loaded nanoparticles modified with thiolated trimethyl chitosan and wheat germ agglutinin provide an attractive strategy for improving the oral absorption of PNS.
CRISPER-Cas9 identifies growth-related subtype of glioblastoma with therapeutical significance through cell line knockdown
Authors: Zhao Nannan , Weng Siyuan , Liu Zaoqu , Xu Hui , Ren Yuqin , Guo Chunguang , Liu Long , Zhang Zhenyu , Ji Yuchen , Han Xinwei 
Published: March 2023

Abstract
Background
Glioblastoma (GBM) is a type of highly malignant brain tumor that is known for its significant intratumoral heterogeneity, meaning that there can be a high degree of variability within the tumor tissue. Despite the identification of several subtypes of GBM in recent years, there remains to explore a classification based on genes related to proliferation and growth.
Methods
The growth-related genes of GBM were identified by CRISPR-Cas9 and univariate Cox regression analysis. The expression of these genes in The Cancer Genome Atlas cohort (TCGA) was used to construct growth-related subtypes (GGSs) via consensus clustering. Validation of this subtyping was performed using the nearest template prediction (NTP) algorithm in two independent Gene Expression Omnibus (GEO) cohorts and the ZZ cohort. Additionally, copy number variations, biological functions, and potential drugs were analyzed for each of the different subtypes separately.
Results
Our research established multicenter-validated GGSs. GGS1 exhibits the poorest prognosis, with the highest frequency of chr 7 gain & chr 10 loss, and the lowest frequency of chr 19 & 20 co-gain. Additionally, GGS1 displays the highest expression of EGFR. Furthermore, it is significantly enriched in metabolic, stemness, proliferation, and signaling pathways. Besides, we screened CCT128930 and Foretinib as potential therapeutic agents for GGS1 which was an independent poor prognostic factor. GGS2 has a moderate prognosis, with a slightly higher proportion of chr 7 gain & chr 10 loss, and the highest proportion of chr 19 & 20 co-gain. The prognosis of GGS3 is the best, with the least chr 7 gain & 10 loss and EGFR expression.
Conclusions
These results enhance our understanding of the heterogeneity of GBM and offer insights for stratified management and precise treatment of GBM patients.
Lifestyle management knowledge, attitude and practice among women with polycystic ovary syndrome in Guizhou, China: A cross-sectional study
Authors: wang lianhong , liu Ying , guo yunmei , yan xin , ding rui , huang shiming 
Published: March 2023

Abstract

Background
Polycystic ovary syndrome (PCOS) is a common metabolic and endocrine disorder and is associated with clinical complications. The aim of this study was to evaluate the life management knowledge, attitudes and practice level in Gui Zhou among women with PCOS .
Methods
A cross-sectional study using self-administered questionnaires was conducted .The questionnaire including demographics and life management-related knowledge, attitudes and practices. Stepwise multiple regression was used to identify factors affecting life management behavior.
Results
Overall, 207 women with PCOS participated in this study. The knowledge mean score was 7.71 ± 3.15,attitude mean score was 42.89 ± 7.12 and practice mean score was 12.45 ± 4.13 .45.80% of participants got some health education information for PCOS lifestyle management in the past. Multiple regression analysis revealed that the main factors influencing the behavior of life management among participants were education( B = 2.051, P = 0.007), attitude (B = 0.534, P = 0.043) and knowledge ( B = 0.332, P = 0.021). The model showed 47.5% of variance being shared with the dependent and independent variables (R2 = 0.475, F = 47.661).
Conclusion
Our study observes majority of women with PCOS have adequate knowledge and positive attitude, while poor health behavior in PCOS management. Future research should focus on how to improve health behavioral practices in patients with PCOS.
Effect of ultrasound-guided lung recruitment to reduce pulmonary atelectasis after non-cardiac surgery under general anesthesia: a systematic review and meta-analysis of randomized controlled trials
Authors: Liao Bucheng , Liao Wuhao , Liu Shujuan , Wu Xinhai 
Published: March 2023

Abstract
Background
At present, the application of bedside lung ultrasound is increasing gradually, but there is no relevant expert consensus or guidance for its evaluation in the field of perioperative anesthesia. Through this meta-analysis, we tried to determine the impact of ultrasound-guided lung recruitment maneuvers (LRM) on perioperative patients.
Methods
We searched PubMed, Cochrane Library database, Embase and Clinical trials gov for the randomized controlled trials (RCTs) published up to December 31, 2022. The primary outcome was the incidence of postoperative atelectasis. Secondary outcomes included lung ultrasound score (LUS), the incidence of postoperative pulmonary complications (PPCs), the incidence of hypoxemia during resuscitation, driving pressure, lung compliance, mean arterial pressure (MAP), and heart rate (HR). A total of 443 patients were examined in nine randomized controlled trials.
Results
The incidence of atelectasis after surgery in patients with ultrasound-guided LRM was less (RR: 0.31; 95% CI: 0.25–0.40; p < 0.05), the LUS (WMD: -6.24; 95% CI: -6.90-5.59; p < 0.05) and the LUS of each part (LUS difference in front lung region (WMD: -2.00; 95% CI: -2.49 to -1.51; p < 0.05); LUS difference in lateral lung region (WMD: -2.50; 95% CI: -3.20 to -1.80; p < 0.05); The LUS of the posterior lung region was different (WMD: -3.24; 95% CI: -4.23 to -2.24; p < 0.05), and the incidence of hypoxemia during resuscitation was lower (RR: 0.33; 95% CI: 0.15 to 0.72; p < 0.05), and the lung compliance was higher (WMD: 5.30; 95% CI: 3.25 to 7.35; p < 0.05). There was no significant difference in PPCs (RR: 0.84; 95% CI: 0.41 to 1.70; p = 0.63), driving pressure (WMD: -0.24; 95% CI: -1.63 to 1.15; p > 0.05), MAP (WMD: -1.69; 95% CI: -1.69 to 2.40; p > 0.05) and HR (WMD: -2.52; 95% CI: -8.66 to 3.63; p > 0.05).
Conclusion
Ultrasound-guided lung recruitment manoeuvres can enhance perioperative lung aeration and lung compliance while reducing the development of atelectasis.Furthermore, these effects of ultrasound-guided lung recruitment manoeuvres are superior to non-ultrasound-guided ventilation strategy.