bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prognostic value of atherogenic index of plasma in pulmonary hypertension
Authors: Chen Meng-Qi , Wang An , Wan Chuan-Xue , Ruan Bin-Qian , Tong Jun , Shen Jie-Yan 
Published: January 2025

BackgroundThe atherogenic index of plasma (AIP) is a brand-new lipid parameter that has been used to assess various cardiovascular events. This study aimed to investigate the prognostic value of AIP in patients with pulmonary hypertension (PH).MethodsThis retrospective study was conducted at Shanghai Jiao Tong University School of Medicine affiliated Renji Hospital, and included data from 125 PH patients treated during 2014–2018. The endpoint events of this study were clinical worsening outcomes. PH patients include those from group 1 and group 4. AIP was determined as the logarithm of the blood triglycerides ratio to high-density lipoprotein cholesterol.ResultsThe 1-year, 3-year, and 5-year incidence rates of clinical worsening outcomes in PH patients in this study were 20.0, 44.8, and 54.4%, respectively. The median age of the PH patients was 38.00 years, with females accounting for 90.4%. After controlling for multivariable factors, the results of Cox regression analysis indicated that AIP was an independent predictor of adverse outcomes with a hazard ratio and 95% confident interval (CI) of 2.426 (1.021–5.763). The positive linear relationship of AIP was evaluated using restricted cubic spline analysis. Kaplan–Meier curves showed a significantly higher events rate in patients with AIP ≥ 0.144 compared to those with AIP &lt; 0.144 (p = 0.002). Four potential prognostic variables, including AIP, were identified by LASSO regression to construct a nomogram. Compared to the model minus AIP, the AUC of the nomogram displayed a non-significant improvement (0.749 vs. 0.788, p = 0.298). In contrast, the results of net reclassification improvement (0.306, 95% CI: 0.039–0.459, p &lt; 0.001) and integrated discrimination improvement (0.049, 95% CI: 0.006–0.097, p = 0.020) demonstrated significant enhancements in the predictive ability of the model when AIP was added to the clinical model.ConclusionAIP is an independent predictor of long-term clinical worsening in PH patients, and its inclusion in prognostic models could improve risk stratification and management.
A bibliometric and visualized analysis of heartland virus
Authors: Zhang Huiying , Zhang Leiliang 
Published: January 2025

BackgroundHeartland virus (HRTV) is an emerging tick-borne bunyavirus first detected in 2009. The purpose of this study was to utilize bibliometric analysis to assess the research trends, key foci, and progress of HRTV. This analysis aims to provide valuable references and insights for future basic research and prevention and control of HRTV to promote the progress and development of related fields.MethodsThe Web of Science Core Collection (WOSCC) was used to extract global publications on the HRTV from 2013 to 2024. VOSviewer, CiteSpace, Scimago Graphica, and Bibliometrix were used to process the data and visualize the results.ResultsA stable trend in publication numbers was observed, with 82 articles from 17 countries. The United States led in publications, with significant contributions from the Centers for Disease Control and Prevention-USA. Keywords indicated research emphasis on “Heartland virus” and “severe fever.”ConclusionHRTV research is in a phase of continuous and progressive growth, with a steady literature output over the past decade, indicating this field’s wide interest and importance in the research community. Currently, researchers are focusing on pathogenesis, immune response, vector relationships, and epidemiology, providing valuable insights for future studies.
Neuroinflammation mediates the progression of neonate hypoxia-ischemia brain damage to Alzheimer’s disease: a bioinformatics and experimental study
Authors: Zhang Shengjie , Zhang Ruqiu , Chen Zhaoqin , Shao Zihan , Li An , Li Fan , Huang Fang 
Published: January 2025

BackgroundTraumatic brain injury (TBI) can generally be divided into focal damage and diffuse damage, and neonate Hypoxia-Ischemia Brain Damage (nHIBD) is one of the causes of diffuse damage. Patients with nHIBD are at an increased risk of developing Alzheimer’s disease (AD). However, the shared pathogenesis of patients affected with both neurological disorders has not been fully elucidated.PurposeWe here aim to identify the shared molecular signatures between nHIBD and AD. We used an integrated analysis of the cortex gene expression data, targeting differential expression of genes related to the mechanisms of neurodegeneration and cognitive impairment following traumatic brain injury.MethodsThe gene expression profiles of Alzheimer’s disease (GSE203206) and that of Neonate Hypoxia-Ischemia Brain Damage (GSE23317) were obtained from the Gene Expression Omnibus (GEO) database. After identifying the common differentially expressed genes (DEGs) of Alzheimer’s disease and neonate Hypoxia-Ischemia Brain Damage by limma package analysis, five kinds of analyses were performed on them, namely Gene Ontology (GO) and pathway enrichment analysis, protein–protein interaction network, DEG-transcription factor interactions and DEG-microRNA interactions, protein-drug interactions and protein-disease association analysis, and gene-inflammation association analysis and protein-inflammation association analysis.ResultsIn total, 12 common DEGs were identified including HSPB1, VIM, MVD, TUBB4A, AACS, ANXA6, DIRAS2, RPH3A, CEND1, KALM, THOP1, AREL1. We also identified 11 hub proteins, three central regulatory transcription factors, and three microRNAs encoded by the DEGs. Protein-drug interaction analysis showed that CYC1 and UQCRFS1 are associated with different drugs. Gene-disease association analysis shows Mammary Neoplasms, Neoplasm Metastasis, Schizophrenia, and Brain Ischemia diseases are the most relevant to the hub proteins we identified. Gene-inflammation association analysis shows that the hub gene AREL1 is related to inflammatory response, while the protein-inflammation association analysis shows that the hub proteins AKT1 and MAPK14 are related to inflammatory response.ConclusionThis study provides new insights into the shared molecular mechanisms between AD and nHIBD. These common pathways and hub genes could potentially be used to design therapeutic interventions, reducing the likelihood of Alzheimer’s disease development in survivors of neonatal Hypoxic-Ischemia brain injury.
A cross-sectional study exploring the perception of exercise oncology in the Italian population
Authors: Borsati Anita , Giannarelli Diana , Pase Giampaolo , Ciurnelli Christian , Toniolo Linda , Trestini Ilaria , Tregnago Daniela , Belluomini Lorenzo , Sposito Marco , Insolda Jessica , Milella Michele , Schena Federico , Pilotto Sara , Avancini Alice 
Published: January 2025

IntroductionWe aim to examine the population’s perception of physical exercise in patients with cancer.Materials and methodsAn anonymous survey was conducted to reach a sample of Italian adults. The questionnaire investigated sociodemographic factors, physical exercise levels, and perceptions about the importance, benefits, and safety of exercise, the support from oncologists and family/friends, as well as the capability and ease of patients of exercise.ResultsOverall, 838 persons participated in this survey. The majority of respondents agree that exercise is important (60.5%) and beneficial (61.5%) for patients with cancer during anticancer treatments, whereas 40.2% believed in its safety. Forty-two percent and 51.9% of participants expressed a positive opinion regarding the advice of oncologists and the encouragement of family/friends to exercise, respectively. Only 27.2% of respondents feel that patients are capable of exercising, and 9.0% agree that it is easy for them.ConclusionAlthough the population has a favorable perception of the importance and benefits of physical exercise, they do not still believe that patients are capable of performing it. Increasing awareness of the feasibility of a physical exercise intervention in the context of cancer is crucial to supporting patients.
The role of VANGL2 in glioma oncogenesis and progression: insights into expression profiles and prognostic relevance
Authors: Zhao Mingyu , Chen Shanshuang 
Published: January 2025

IntroductionThe Wnt/planar cell polarity (PCP) signaling pathway is pivotal in regulating various biological processes such as early embryonic development, neural crest cell migration, and cancer invasion. Despite advances in understanding the role of Wnt/PCP pathway dysregulation in tumorigenesis, numerous unanswered questions remain. Our study focused on VANGL2, a core PCP gene, to elucidate its potential mechanistic involvement in cancer development.MethodsA systematic analysis was conducted to assess VANGL2 expression patterns at both transcriptional and proteomic levels. Functional enrichment analysis was performed to investigate the biological pathways associated with VANGL2 in glioma. In vitro experiments were conducted to assess the impact of VANGL2 on glioma cell behaviors. Furthermore, rigorous methodologies were employed in survival analysis to control for confounding factors.ResultsWe identified substantial upregulation of VANGL2 gene in both low-grade glioma (LGG) and glioblastoma (GBM). Functional enrichment analysis of genes positively associated with VANGL2 in glioma underscored their enrichment in Notch signaling and pathway regulating pluripotency of stem cells. In vitro experiments further confirmed that VANGL2 promotes glioma cell migration, invasion, proliferation, and tumor sphere formation. We identified a significant correlation between increased VANGL2 expression and IDH mutation in glioma patients. Elevated VANGL2 expression was identified as a predictor of poor prognosis in glioma.ConclusionOur analysis of the expression and prognostic features of the core PCP gene VANGL2 underscored its critical roles in glioma oncogenesis and progression.
Decentralized clinical trials are better for the participants and for the planet: the case study of a double-blind randomized controlled trial in Singapore (PROMOTE study)
Authors: Fries Lisa R. , Khaled Nadia , Viveros Santos Ivan , Suniega-Tolentino Elvira , Sesing Motshewa , Toh Melissa P. S. , Yang Chui Yuen , Chan Shiao Yng , Colombo Mottaz Sara 
Published: January 2025

IntroductionNovel technologies have enabled the decentralization of many aspects of clinical trials, but little research has been done on the impact of these changes on the participant experience, trial operations, or the environment.MethodsA fully decentralized clinical trial conducted in Singapore is used as a case study to evaluate the operational outcomes, environmental impact (via life cycle assessment), and participants experience (qualitative interviews) of the decentralized model compared to a traditional study with in-person visits.ResultsThe decentralized study achieved high participant retention rates (97%) and high completion rates for clinical data, even for biological samples. Participants found the decentralized model to be convenient and safe, especially during the pandemic. Moreover, the decentralized model was found to be more environmentally friendly and less detrimental to human health compared to traditional face-to-face clinical trials, primarily by reducing participants’ use of cars for site visits.DiscussionWhile this study focused on the environmental impact, it is important to consider other factors such as participant safety, convenience, and data quality when evaluating the suitability of a decentralized clinical trial approach. Careful planning of data flow, database structure, and data protection measures is essential. This study contributes to improving the environmental footprint of clinical trials. Environmental sustainability should be among the factors that are evaluated when selecting trial models. Decentralized and hybrid clinical trials offer efficiency, effectiveness, and environmental benefits. Further research and adoption of these approaches are encouraged.
Questionnaire survey on the clinical application of Hall technique preformed metal crowns in caries of primary molars in China
Authors: Wang Junhui , Zhang Baize , Chen Yujiang , Wang Lulu , Du Yang , Ge Xin , Liu Fen , Gong Jing , Wang Xiaojing 
Published: January 2025

ObjectiveTo analyze the clinical application and limiting factors of the Hall technique (HT) preformed metal crowns in caries of primary molars and to provide reference for its clinical application based on a questionnaire survey.Materials and methodsFrom June to December 2022, a questionnaire was distributed to pediatric dentists through the WeChat platform using “Questionnaire Star” to analyze the clinical application and influencing factors of the HT preformed metal crowns in caries of primary molars.ResultsA total of 700 survey questionnaires were distributed, and 650 valid questionnaires were recovered, with a effectiveness rate of 92.86%. In terms of the awareness level of the HT, only 11.08% of pediatric dentists fully understood, while 19.85% of those were completely unaware; In terms of the understanding methods, classes study accounted for 47.60%, and 28.79% of pediatric dentists understood through literature; In terms of the application of the HT, 46.15% of pediatric dentists had applied it, only 11.23% had frequently applied it, and 53.85% had never applied it; In terms of the usage time, the highest proportion was between 1 and 3 years, accounting for 40.33%, and only 9.67% were over 5 years; In terms of the choosing of indications, only 26.62% of pediatric dentists could select indications correctly; Regarding the choice of treatment methods for children who do not cooperate, only 19.54% of pediatric dentists chose the HT. The education background and nature of the workplace had a statistically significant difference in the application of the HT, the number of years of application, the selection of indications, and the choice of treatment methods for children who do not cooperate.ConclusionsThe survey showed that the awareness level and application frequency of the HT were relatively low in China. The understanding methods mainly learned through classes study.Clinical relevanceIt is necessary to further promote the development of continuing education projects with the theme of clinical application of the HT and the guidance of clinical operation standards, in order to promote the clinical popularization of it in China.
PENGARUH LITERASI KEUANGAN, EXPERIENCED REGRET, RISK TOLERANCE, DAN TEKNOLOGI INFORMASI TERHADAP KEPUTUSAN INVESTASI (Studi Kasus Pada Masyarakat Kota Jepara)
Authors: Alivia Maura , Nadhifah Isyfa Fuhrotun 
Published: January 2025

Penelitian ini bertujuan untuk mengatahui pengaruh literasi keuangan, experienced regret, risk tolerance, dan teknologi informasi terhadap keputusan investasi masyarakat Kota Jepara. Jenis investasi yang digunakan dalam penelitian ini adalah investasi aset riil dan aset keuangan. Penelitian ini termasuk dalam jenis penelitian kuantitatif. Data diperoleh menggunakan data primer berupa kuesioner yang disebarkan melalui google form. Populasi dalam penelitian ini adalah masyarakat Kota Jepara dengan rentang usia 18-40 tahun yang telah melakukan investasi dengan periode waktu minimal satu tahun dan berdomisili di Kota Jepara. Sampel dalam penelitian ini dihitung dengan menggunakan rumus rao purba yang menghasilkan jumlah yang dibulatkan menjadi 100 responden. Teknik pengambilan sampel yang digunakan adalah teknik accidental sampling. Alat analisis data yang digunakan yaitu analisis regresi linier berganda menggunakan SPSS (Statistical Product and Service Solution) versi 22. Hasil penelitian ini menunjukkan bahwa variabel literasi keuangan berpengaruh positif dan signifikan terhadap keputusan investasi, experienced regret tidak berpengaruh terhadap keputusan investasi, risk tolerance berpengaruh positif dan signifikan terhadap keputusan investasi dan teknologi informasi berpengaruh positif dan signifikan terhadap keputusan investasi.
Estratégias integradas de segurança com inteligência artificial em eventos esportivos de grande porte: lições das Olimpíadas e da Copa do Mundo
Authors: Pacheco Renan Lemos 
Published: January 2025

Diante da relevância dos benefícios da utilização da IA, reconhecimento facial, especialmente nas atividades desempenhadas pela Polícia Militar, justifica-se este estudo. O objetivo deste estudo estudar o desenvolvimento e utilização da Inteligência Artificial, neste caso do reconhecimento facial na segurança pública realizando uma revisão de literatura para estabelecer o estado da arte desta no âmbito da segurança dos megaeventos. A metodologia utilizada foi um estudo de revisão de literatura desenvolvido partindo de pesquisa bibliográfica, de cunho qualitativo e exploratório. Os resultados mostraram que o cenário atual de segurança pública tem demonstrado que a inteligência artificial já desempenha um papel importante para melhorar a eficiência operacional das corporações, contudo sua implementação traz preocupações acerca da vigilância em massa e possiblidade de violação dos direitos humanos devido a ausência de regulamentação específica no país. Conclui-se que o futuro da segurança em eventos esportivos com base na utilização de tecnologias avançadas como a inteligência artificial, e de maneira específica, do reconhecimento facial apresenta grande potencial podendo auxiliar na melhoria da eficiência e da eficácia na identificação de criminosos.
EDUKASI PUBLIK, PENINGKATAN PEMAHAMAN PENETAPAN HARGA JUAL PRODUK PADA KELOMPOK USAHA AKU-UPPKA (ANDALAN KELOMPOK USAHA- USAHA PENINGKATAN PENDAPATAN KELUARGA AKSEPTOR) KOTA PEKANBARU PROPINSI RIAU
Authors: Indarti Indarti , Aljufri Aljufri , Apriliyani Ika Berty 
Published: January 2025

Kegiatan pengabdian masyarakat ini bertujuan untuk memberikan pemahaman dan keterampilan dalam penentuan harga jual produk usahanya . Penetapan harga jual produk merupakan salah satu jenis suatu keputusan manajemen yang begitu penting. Para pelaku usaha harus tepat dalam menentukan harga jual haruslah tepat. Salah satu kendala yang dihadapi paara pelaku UMKM tersebut adalah kurangnya pengetahuan dalam aspek keuangan, seperti penentuan Harga Pokok Produksi (HPP) sebagai dasar dalam menentukan harga jual produk. Masalah tersebut dirasakan juga oleh pelaku usaha di kelompok usaha lima puluh kota AKU UPPKA. Berdasarkan hasil observasi awal, tim pengabdian masyarakat mendapatkan informasi mengenai kurangnya pendampingan pelaku usaha dalam menentukan harga jual produk.. Kegiatan utama yang dilaksanakan dalam kegiatan pengabdian masyarakat ini adalah pendampingan penentuan harga jual produk. Tujuan kegiatan pengabdian ini |adalah untuk meningkatkan pemahaman pelaku UMKM dalam menentukan harga jual produk. Metode yang digunakan dalam kegiatan pengabdian kepada masyarakat ini menggunakan metode wawancara, observasi, dan dokumentasi. Hasil dari kegiatan ini adalah para pelaku UMKM mampu melakukan perencanaan keuangan pada bisnisnya.

Kata Kunci:
PENINGKATAN TRANSPARANSI LAPORAN KEUANGAN DAN KINERJA BUMDES
Authors: Seswandi Agus , Burhan Burhan , Oemar Fahmi , Bambang Bambang 
Published: January 2025

Badan Usaha Milik Desa (BUMDes) are institutions established by the village government to manage businesses owned by the village and aim to improve the welfare of village communities. In practice, BUMDes often face several problems, especially related to transparency and financial report performance. Some of the problems are lack of transparency; Financial reports that should be published to the village community are often not done routinely or completely.; Unclearness in Financial Separation, there is difficulty in separating BUMDes finances from village finances. The next problem is Weak Financial Report Performance caused by; Lack of Management Capacity: Many BUMDes are managed by individuals who lack the ability or knowledge in financial management and accounting. The targets and outputs to be achieved are 1) Increased capacity of BUMDes managers, 2) Increased implementation of a better financial recording system and stricter supervision and audits 3) Changes Better transparency can also be built through routine reporting. The solution is assistance on increasing the capacity of BUMDes managers, 2) Regarding partner problems, efforts need to be made to improve the implementation of a better financial recording system and stricter supervision and audits. The method of implementing the activity consists of mentoring partners. The methods used are 1) interactive discussion. 2) mentoring/training. This mentoring activity succeeded in increasing the understanding of BUMDes administrators about the importance of transparency in financial reports. Through an interactive approach and constructive discussion, participants can better understand the challenges faced and the solutions that can be applied to increase transparency in their BUMDes financial reports. In the future, it is hoped that BUMDes can implement this transparency practice more consistently to build public trust, improve financial performance and ensure the continuity of BUMDes businesses.

Keywords: BUMDEs, Transparency, Financial Reports
KARAKTERISTIK SELAI BUAH NAGA (Hylocereus polyrhizus) MEMAR DENGAN FORMULASI PENAMBAHAN BUAH NANAS (Ananas comosus Merr.)
Authors: Burhan Abi , Putri Manurung Nancy Eka , Hermialingga Septi , Cahya Gemala 
Published: January 2025

The objective of this research is to know characteristics of breakable dragon fruit jam with adding pineapple puree. The research design used was a complete factorial random design. The cutting range with breakable area (A), with the type: A1 = 1 cm; A2 = 2 cm; and A3 = 3 cm. The second treatment is concentration of pineapple puree on dragon fruit jam (B), with the type: B1 = 0 % pineapple puree, B2 = 25 % pineapple puree, B3 = 50 % pineapple puree, B4 = 75 % pineapple puree, B5 = 100 % pineapple puree. The test parameters observed are water content, vitamin C content, crude fiber content, and total plate count. The results showed that adding pineapple pure can change dragon fruit jam characteristic. The cutting range 3 cm from breakable area is the safest dragon fruit to be raw material jam. The best treatment was obtained from A3B4 in concentrate pineapple puree is 75%.
PENGARUH PERBANDINGAN KOMPOSISI TERHADAP KUALITAS BIOBRIKET DARI CAMPURAN KULIT UBI KAYU DAN TONGKOL JAGUNG
Authors: Wijayanti Metta , Oktriyanti Melantina , Oktaviani Erika Dwi , Hartati Nina 
Published: January 2025

The general people is aware that maize cobs and cassava peels are waste materials that can contaminate the environment. One way to boost the financial worth of corn cobs and cassava peels is to turn them into biobriquettes. Through the creation of briquettes. The purpose of this study is to ascertain how the composition of the cassava peel and corn cob mixture affects the biobriquettes' quality. On the biobriquettes' quality. In order to create biobriquettes, a carbonization process at 200 C is used, followed by mixing with different ratios of corn cob and cassava peel (10:90, 10:90, and 10:90). composition of up to 6% of the total material to be molded, with 10:90, 30:70, 50:50, 70:30, and 90:10 components, as well as adhesive. All of the material that has to be molded. After that, molding and 3 psi pressing were completed. In order to assess the biobriquettes' quality, the following A variety of the biobriquettes' properties, including their moisture content, ash content, fly content, and calorific value, were examined in order to assess the quality of the product. According to the findings, biobriquettes with a 50:50 raw material composition, 4,69% moisture content, 4,69% ash content, and 4,69% calorific value produced the greatest out comes. 67,37%, carbon tethered, 4,69%, fly content 23%, ash content 4,94%, and calorific value 5602 cal/gr. Tethered carbon at 67,37%. The results of this biobricket production show that biobriquettes made from a mixture of cassava peel and corn cob can be used as an alternative fuel.