bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Impact of Administration Formats on SIS-A Scores
Authors: Carlson Sarah R. , Thompson James R. , Shaw Leslie 
Published: December 2022

Abstract
Many U.S. states use the Supports Intensity Scale—Adult Version (SIS-A; Thompson et al., 2015) to inform the distribution of public funds for long-term services and supports. Throughout the COVID-19 pandemic, many states began administering the SIS-A virtually instead of in person. Because administration format has the potential to influence SIS-A scores and, consequently, impact the funding people receive for long-term services and supports, this study examined the stability of support need scores, as measured by the SIS-A, over two time periods: (a) when assessments were conducted in person and (b) when assessments were conducted virtually using remote technology. Specifically, the influence of assessment administration formats on SIS-A scores and on the perceptions of SIS-A assessors were investigated. Results revealed that the virtual administration format impacted SIS-A scores, but the impact was of little to no practical importance.
Perbedaan Efektifitas Oral Hygiene Antara Povidone Iodine Dengan Chlorhexidine Terhadap Clinical Pulmonary Infection Score Pada Penderita Dengan Ventilator Mekanik
Authors: Sebayang Kurniadi , Pujo Jati Listiyanto , Arifin Johan 
Published: December 2022

Latar belakang: Antiseptik oral hygiene merupakan salah satu cara non farmakologi yang dapat menurunkan insiden Ventilation Associated Pneumonia (VAP) dengan menurunkan skor Clinical Pulmonary Infection Score (CPIS) pada penderita dengan ventilator mekanik. Chlorhexidine adalah antiseptik yang lebih mampu mencegah pembentukan biofilm dibandingkan dengan povidone iodine. Tujuan: Mengetahui chlorhexidine 0,2% lebih efektif menurunkan angka Clinical Pulmonary Infection Score (CPIS) dibandingkan dengan povidone iodine 1% pada penderita dengan ventilator mekanik. Metode : Merupakan penelitian eksperimental, dua subjek dibagi dua kelompok sama besar (n =16). Kelompok chlorhexidinee 0,2 % dan kelompok kontrol povidone iodine 1%. Kedua kelompok sebelum dan setelah perlakuan dilakukan pemeriksaan CPIS, yaitu: suhu, analisa gas darah, sekret trakea, darah rutin dan foto ronsen dada. Uji wilcoxon adalah uji korelatif untuk melihat GC plaque sebelum dan setelah perlakuan.Sedangkan uji spearman melihat korelasi GC plaque dan skor CPIS pada kelompok perlakuan. Hasil: Hasil skor CPIS berbeda makna pada kelompok I (p<0,05). Analisis komparatif selisih skor sebelum dan sesudah perlakuan kedua kelompok berbeda bermakna (p<0,05). Skor GC plaque sebelum [6,00 (5,60-7,00)] dan setelah aplikasi chlorhexidinee 0,2% [7,00 (6,80-7,20)] menunjukkan hasil berbeda bermakna (p= 0,000). Uji spearman skor GC plaque dan CPIS menunjukkan hasil berbeda tidak bermakna, hasil korelatif negatif. Kesimpulan: Chlorhexidinee 0,2% merupakan antiseptik orofaring yang lebih efektif menurunkan skor CPIS dibandingkan dengan povidone iodine 1% pada pasien dengan ventilator mekanik. Tidak ada korelasi antara kenaikan skor GC plaque dengan penurunan skor CPIS.
Pengaruh Induksi dengan Propofol dan Etomidat Terhadap Kadar Gula Darah
Authors: Bernardus Johan Eduard , Witjaksono Witjaksono , Soenarjo Soenarjo 
Published: December 2022

Latar belakang: Etomidat memiliki keunggulan karakteristik berupa keamanan dari segi hemodinamik, respirasi, maupun neuroproteksi, akan tetapi efeknya terhadap fungsi adrenal, kortisol dan menurunkan kadar gula darah menjadikan penggunanya terbatas. Tujuan: Membuktikan adanya perbedaan pengaruh pemberian propofol 2,5 mg/kgBB intravena dan etomidat 0,2 mg/kgBB intravena terhadap penurunan kadar gula darah. Metode: Penelitian ini menggunakan desain Randomized Clinical Control Trial pada 38 pasien yang menjalani anastesi umum, dibagi menjadi 2 kelompok perlakuan (n=19), etomidat dan propofol. Masing-masing kelompok diperiksa kadar gula darah sebelum induksi,2 dan 8 jam setelah induksi. Uji statistik Wilcoxon Signed Rank Test digunakan untuk membandingkan kadar gula darah pada masing-masing kelompok sedangkan uji statistik Mann Whitney U Test digunakan untuk membandingkan antar kelompok perlakuan. Hasil: Terdapat perbedaan bermakna kadar gula darah sebelum dan 2 jam pasca induksi pada kelompok etomidat (122,42+4,98 vs 78,73+4,56), tetapi tidak pada 8 jam pasca induksi. Hasil penelitian ini menunjukkan bahwa pengurangan dosis etomidat sampai 0,2 mg/kgBB masih menurunkan kadar gula secara signifikan sampai < 8 jam pasca induksi. Pada kelompok propofol terdapat peningkatan bermakna kadar gula darah 2 jam pasca induksi (P=0,000). Hasil penelitian ini menunjukkan bahwa propofol tidak memiliki efek menurunkan kadar gula darah. Kesimpulan: Pemberian etomidat 0,2 mg/kgBB menurunkan sintesis gula darah pada 2 jam pasca induksi namun kembali normal 8 jam pasca induksi. Pemberian propofol 2,5 mg/kgBB tidak menyebabkan penurunan kadar gula darah.
Maria Gutowska-Ibbs, Pozarejestracyjne stosowanie produktów leczniczych a badania kliniczne. Ramy prawne i praktyka w podmiotach leczniczych w Polsce, seria Monografie Prawnicze, Wydawnictwo C.H. Beck, Warszawa 2022 (opr. Paulina Jachimowicz-Jankowska)
Authors: Jachimowicz-Jankowska Paulina 
Published: December 2022

Maria Gutowska-Ibbs, Pozarejestracyjne stosowanie produktów leczniczych a badania kliniczne. Ramy prawne i praktyka w podmiotach leczniczych w Polsce, seria Monografie Prawnicze, Wydawnictwo C.H. Beck, Warszawa 2022, ss. 208, ISBN 978-83-8291-229-6.
Paulina Jachimowicz-Jankowska
„Deeper Sommertage“ und Bauhausjahre
Authors: Köpnick Gloria 
Published: December 2022

Abstract
In der Lyonel-Feininger-Galerie, dem Museum für grafische Künste in Quedlinburg werden aus dem Nachlass von Hermann Klumpp, dem Begründer des Museums, zwei besondere Fotoalben von Lyonel Feininger (1871–1956) aus den frühen 1930er Jahren bewahrt: Eines gibt Zeugnis von einer Reise an die Ostsee und das andere entstand zum Abschied von Lyonel und seiner Frau Julia Feininger (1880–1970) aus Dessau. Die Aufnahmen verdeutlichen Feiningers Leidenschaft für die Fotografie, eine noch immer unterschätzte Facette im Schaffen des Bauhausmeisters und Malers.
Fotografien aus dem Untergrund
Authors: Rasch Marco 
Published: December 2022

Abstract
Die Saxonia-Freiberg-Stiftung in Freiberg in Sachsen erwarb 2010 den Großteil des fotografischen Nachlasses des Ingenieurs Wolfgang Schreiber (1940–2005). Den Hauptbestandteil des Konvoluts bilden fast 4 500 gerahmte stereoskopische Diapositive, deren motivischer Schwerpunkt auf der Dokumentation des späten Erzbergbaus vor allem in Sachsen und im Harz liegt. Der Artikel stellt den zwischen Mitte der 1970er und Mitte der 1990er Jahre von Wolfgang Schreiber aufgenommenen Bestand vor, der von der Stiftung erschlossen und anschließend in Kooperation mit der Deutschen Fotothek in der Sächsischen Landesbibliothek – Staats- und Universitätsbibliothek (SLUB) Dresden über das Landesdigitalisierungsprogramm für Wissenschaft und Kultur des Freistaates Sachsen digitalisiert wurde und von der SLUB aktuell online publiziert wird.
Cold Storage?
Authors: Leidig Franziska , Blaschke-Walther Kristina , Henniges Ute , Brückle Irene 
Published: December 2022

Abstract
Six face- and back-mounted chromogenic print samples (each 120 × 160 cm) and one pre-damaged original photograph (120 × 120 cm) were exposed to alternating temperature conditions. Cold storage was set at 8 °C with a slightly fluctuating relative humidity at an average of 55 % in a cooling chamber; room temperature storage occurred at 19 to 27 °C depending on the prevailing weather conditions. The samples were exposed alternatingly to these setups in a 24-hour rotation over five weeks to assess the effect of strong and rapid fluctuations on the stability of the composite. After about one week under the extreme, stress-intensive testing conditions, irreversible deformation, and a local loss of translucency occurred. Further local delamination was observed on the pre-damaged original artwork. Exceeding the dew point temperature, which occurred in our experimental setup and should be avoided, resulted in condensation on the acrylic surface and led to extensive streaks and, in combination with the electrostatic charge, to extreme dust deposits. These findings suggest that cold storage cannot be recommended for face- and back-mounted chromogenic prints.
Intra-operative tissue sampling and microbiological analyses during minor lower limb amputations in patients with diabetes are poorly reported and difﬁcult to interpret
Authors: Gulamhussein Mohamed , Sohawon Ridwaan , Travers Hannah , Wall Michael 
Published: December 2022

Diabetic foot disease (DFD) is a leading cause of acute sepsis and has long-term consequences for patients. It poses a strain on health resources in both the developed and developing world, with a signiﬁcant impact on patient quality of life due to the associated complications of DFD and the often multiple interventions required to control infection and preserve limb tissue. Although there is evidence in the literature regarding early detection and prompt management of this debilitating condition, there is little structured evidence on how to gain accurate tissue sampling with processing to allow targeted antimicrobial therapy from minor amputations where bone cultures have been sent.
Methods: A literature review was conducted to establish the publications on intra-operative bone sampling and processing taken during diabetic foot minor amputations and the pathways described for processing sample acquisition.
Findings: Thirty papers were identiﬁed which highlighted some of the processes involved in the procurement of intraoperative tissue samples. No published paper reported a complete pathway for the ascertainment of samples, transfer and processing of these specimens.
Conclusion: There is no published consistent pathway published for procurement of intra-operative diabetic foot specimens, for their storage, transportation and processing. Without documented, reproducible processes, it is difﬁcult to interpret published results. This makes planning for targeted antibiotic therapy more difﬁcult.
Biochemical alterations in the follicular fluid of bovine peri-ovulatory follicles and their association with final oocyte maturation
Authors: Abdulrahman Alrabiah Noof , Simintiras Constantine A , Evans Alexander C O , Lonergan Patrick , Fair Trudee 
Published: December 2022

Follicular fluid (FF), a product of vascular transudate and granulosa and thecal cell secretions, is the milieu that has evolved to support oocyte growth and maturation which plays a central role in oocyte quality determination. Therefore, a suboptimal FF composition may be reflected in compromised oocyte progression through maturation, fertilization, or embryo development. To date, the composition of bovine FF remains understudied. To address this, we comprehensively characterized the metabolomic constituency of bovine FF in the period during which the oocyte undergoes meiotic maturation. More specifically, FF from pre (−24 h) and peri (−2 h)-ovulatory follicles was profiled by high-throughput untargeted ultra-HPLC tandem mass spectroscopy. A total of 634 metabolites were identified, comprising lipids (37.1%), amino acids (30.0%), xenobiotics (11.5%), nucleotides (6.8%), carbohydrates (4.4%), cofactors and vitamins (4.4%), peptides (3.6%), and energy substrates (2.1%). The concentrations of 67 metabolites were significantly affected by the stage of follicle development, 33.3% (n = 21) were reduced (P ≤ 0.05) by a mean of 9.0-fold, whereas 46 were elevated (P ≤ 0.05) by a mean of 1.7-fold in peri- vs pre-ovulatory FF. The most pronounced individual metabolite concentration decreases were observed in hypoxanthine (98.9-fold), xanthine (65.7-fold), 17β-oestradiol (12.4-fold), and inosine (4.6-fold). In contrast, the greatest increases were in retinal (4.9-fold), 1-methyl-5-imidazoleacetate (2.7-fold), and isovalerylcarnitine (2.7-fold). This global metabolomic analysis of bovine FF temporal dynamics provides new information for understanding the environment supporting oocyte maturation and facilitating ovulation that has the potential for improving oocyte quality both invivo and in vitro.

Lay Summary
The ovaries are part of the female reproductive system, and they produce and store eggs in structures known as ‘follicles’. Depending on the species, one or more follicles release an egg from the ovary during ovulation. FF, which is formed from the secretions of follicle cells and substances delivered from the bloodstream, bathes the eggs as they develop within their follicles. For pregnancy to happen, the egg must be capable of being fertilised by a sperm cell, developing into an embryo and implanting it in the womb. FF has evolved to support the egg to achieve this. Using the cow as a model, this study looks at the composition of FF during the final hours before ovulation, when the egg becomes mature and ready for fertilisation. More than 600 different substances were identified, providing new information, that has the potential to improve egg quality.
Sperm cryopreservation for impaired spermatogenesis
Authors: Hughes G , Martins da Silva S 
Published: December 2022

Sperm cryopreservation for men with severely impaired spermatogenesis is one of the commonest reasons for short-term sperm storage, usually in advance of fertility treatment. Cryopreservation is generally very effective, although not all spermatozoa survive the process of freezing and thawing. This review considers various aspects of freezing sperm, including an overview of methods, appropriate use of cryoprotectants and practical considerations, as well as oxidative stress and mechanisms of cell cryodamage.

Lay summary
Cryopreservation involves freezing of cells or tissues to preserve them for future use. Sperm cryopreservation for men with a very low sperm count is one of the commonest reasons for short-term sperm storage, usually in advance of fertility treatment. Cryopreservation is generally very effective, although not all sperm cells survive the process of freezing and thawing. This review covers various aspects of freezing sperm, including consideration of methods used and mechanisms of cell damage.
The Early Use of Selective Hemoadsorption Based on a Hyper-Crosslinked Styrene-Divinylbenzene Copolymer in Patients with Toxic Rhabdomyolysis Complicated by Acute Kidney Injury (Multicenter Randomized Clinical Trial)
Authors: Masolitin S. V. , Protsenko D. N. , Tyurin I. N. , Magomedov M. A. , Kim T. G. , Grishina L. A. , Bykov A. O. , Gelfand Е. B. , Ignatenko O. V. 
Published: December 2022

Rhabdomyolysis (RM) is a clinical and laboratory syndrome with the underlying destruction of myocytes and the release of intracellular debris into the systemic circulation. In more than 55% of cases, RM is complicated by acute kidney injury (AKI), which necessitates various methods of extracorporeal detoxification and currently is a controversial issue.Aim: to improve the results of treatment of patients with RM of toxic origin complicated by AKI by using early selective hemoadsorption (SH).Material and methods. The study included 36 patients divided into 2 groups. Group 1 included 24 patients who received standard therapy and hemodiafiltration (HDF) as a life-saving intervention. Group 2 comprised 12 patients who underwent early SH to prevent the progression of AKI. We performed a comparative analysis of clinical and laboratory parameters and treatment outcomes in the groups.Results. The use of SH was associated with reduced level of myoglobin on day5 of therapy from 384.1 to 112.4 gg/l (70.7%) vs 335.15 to 219.1 gg/l (34.6%) reduction in the conservative therapy group. By day 7, this parameter was 18.8 (95.1%) and 142.4 (57.5%), respectively (7=0.012). The level of cystatin-C decreased on day 5 from 17.3 to 3.2 mg/l (81.5%) in group 2 and from 14.9 to 11.7 mg/l (21.5%) in group 1. By day 7, this parameter decreased to 2.5 (85.6%) and 14.1 (5.3%) mg/l, respectively (7=0.001). The length of ICU stay in group 2 was 7 (6; 9) days, while in the conservative therapy group it was 12 (7; 13) days (7=0.04). The hospital stay was 12 (10; 16) and 22 (14,5; 24,5) days, respectively (7=0.028).Conclusion. The early use of SH in the intensive therapy helped decrease the levels of markers of endogenous intoxication, AKI severity, improve the filtration capacity of the kidneys, and reduced the length of stay in the ICU and hospital.
Pathogenesis, Prognosis and Outcomes of Multiple Organ Failure in Newborns (Review)
Authors: Golomidov A. V. , Grigoriev E. V. , Moses V. G. , Moses K. B. 
Published: December 2022

Multiple organ failure (MOF) is the leading cause of neonatal mortality in intensive care units. The prevalence of MOF in newborns is currently unclear, since its incidence varies in asphyxia, sepsis, prematurity, and comorbidity, and depends on the level of development and funding of health care in different countries. Sepsis and acute respiratory distress syndrome prevail among the causes of MOF in this category of patients.Aim of the review. To summarize the available literature data on the pathogenesis, therapeutic strategies and outcomes of MOF in newborns.Material and methods. We searched PubMed, Scopus, Web of Science, and RSCI databases using the following keywords: «newborns, multiple organ failure, etiology, pathogenesis, premature, diagnosis, treatment, respiratory support, cardiotonic support», without language limitations. A total of 144 full-text sources were selected for analysis, 70% of which were published in the last five years and 50% were published in the last three years. Criteria for exclusion were low information value and outdated data.Results. The prevalence of MOF in neonates is currently unclear. This could be due to common association of neonatal MOF (as well as the adult one) with various diseases; thus, its incidence is not the same for asphyxia, sepsis, prematurity, and comorbidities. There is no precise data on neonatal mortality in MOF, but according to some reports, it may be as high as 13-50%.In newborns, MOF can be caused by two major causes, intrapartum/postnatal asphyxia and sepsis, but could also be influenced by other intranatal factors such as intrauterine infections and acute interruption of placental blood flow.The key element in the pathogenesis of neonate MOF is cytokinemia, which triggers universal critical pathways. Attempts to identify different clinical trajectories of critical illness in various categories of patients have led to the discovery of MOF phenotypes with specific patterns of systemic inflammatory response. This scientific trend is very promising for the creation of new classes of drugs and individual therapeutic pathways in neonates with MOF of various etiologies.The pSOFA scale is used to predict the outcome of neonatal MOF, however, the nSOFA scale has higher validity in premature infants with low birth weight.Central nervous system damage is the major MOF-associated adverse outcome in newborns, with gestational age and the timing of treatment initiation being key factors affecting risk of MOF development in both full-term and premature infants.Conclusion. The study of cellular messengers of inflammation, MOF phenotypes, mitochondrial insufficiency, and immunity in critically ill infants with MOF of various etiologies is a promising area of research. The pSOFA scale is suggested for predicting the outcome of MOF in full-term infants, while the nSOFA scale should be used in premature infants with low birth weight.
Regional Anesthesia for Carotid Endarterectomy in Patients with Acute Ischemic Stroke (Pilot Study)
Authors: Simonov O. V. , Pryamikov A. D. , Loluev R. Yu. , Suryakhin V. S. , Perevedentseva E. V. , Safronova M. A. , Krasnikov A. L. , Esipov P. S. , Churkin A. A. , Mironkov A. B. , Khripun A. I. 
Published: December 2022

Objective. The aim of this study is to assess the safety of the use of regional anesthesia for performing carotid endarterectomy (CEA) in patients in the acute phase of ischemic stroke.Material and methods. The study included 66 patients in the acute phase of ischemic stroke (atherothrom-botic subtype according to the TOAST classification) who underwent carotid endarterectomy. The inclusion criteria for the study were as follows: acute phase of atherothrombotic ischemic stroke (first 28 days), ipsilateral symptomatic ≥ 50% stenosis of the internal carotid artery, 1-4 points neurological deficit according to the modified Rankin Scale (mRS), 1-13 points neurological deficit according to the National Institutes of Health Stroke Scale (NIHSS), size of the cerebral ischemic lesion ≤ 4 cm. This single-center prospective cohort study compared two anesthetic approaches, regional anesthesia (RA, 46 patients) and general anesthesia (GA, 20 patients). The RA techniques included ultrasound-guided superficial and deep cervical plexus blocks on the side of the surgery.Results. The study found no significant differences in the baseline patient characteristics, surgery techniques and clinical outcomes between the groups. There were no neurological or cardiovascular toxic reactions to the local anesthetics. Conversions from RA to GA were not performed. In the RA group, recurrent ipsilateral ischemic strokes, myocardial infarctions, wound hemorrhagic complications and lethal outcomes did not occur.Conclusion. This pilot study has demonstrated the safety of RA for performing CEA in patients in the acute phase of ischemic stroke. RA provides adequate neuromonitoring and timely intraoperative recognition of «new» ischemic complications. To compare the efficacy of RA and GA for performing CEA in patients with acute ischemic stroke, large randomized controlled trials are needed.