bluuebunny/crossref_metadata_2025_split huggingface dataset:
The excito-repellent activity of five essential oils extracted from local plants against dengue and malaria vectors in Burkina Faso
Authors: Balboné Mahamoudou , Gnankine Olivier , Namountougou Moussa , SOMA Diloma D. , DRABO Samuel F. , ROMBA Rahim , BASSOLE Imael Henri Nestor , DABIRE Roch Kounbobr 
Published: January 2023

Abstract
Using chemical insecticides is the main way to prevent and manage dengue and malaria, two main mosquito-borne diseases. However, the vectors of these diseases have developed resistance to chemical insecticides. Essential oils (EOs) could be used as alternatives because besides their larvicidal and adulticidal properties, they have repellent properties. In Burkina Faso, studies on the repellent properties of essential oils on mosquitoes remained limited. The EOs extracted from five plants (Cymbopogon citratus, Cymbopogon nardus, Eucalyptus camaldulensis, Lippia multiflora, and Ocimum americanum) collected in Ouagadougou were tested on populations of Aedes aegypti and Anopheles gambiae s.l collected in Bobo-Dioulasso and the Kou of Valley, respectively. Susceptible strains of the two species were also tested. DEET and permethrin were used as positive controls. Most of the 5 EOs tested produced irritant effects on adults of Ae. aegypti and An. gambiae. The irritant effects on mosquito adults were significantly influenced by the concentration of the EOs and species of mosquitoes. On An. gambiae s.l, the repellent-irritant effects of C. citratus, C. nardus, and E. camaldulensis EOs were very close to that of DEET. On Ae. aegypti, all our EOs had higher repellent-irritant effects and some of them were very close to DEET. EOs could be used as alternative repellents to pyrethroids in vector control.
STRATEGI PEMBELAJARAN KIAI DALAM MEMBENTUK KARAKTER JUJUR DAN DISIPLIN SANTRI
Authors: Haryanti Nik , Indarti Luluk 
Published: January 2023

Penelitian ini dilatarbelakangi oleh fakta yang terjadi kiai harus mempunyai strategi untuk pembentukan karakter santri. Strategi dalam pembentukan karakter merupakan salah satu metode pendidikan nilai yang komprehensif. Pembelajaran dalam pembentukan karakter santri sudah mulai mengenai dimana santri sudah mempunyai rasa kepedulian terhadap sesama santri yang terwujud dengan saling membantu, mempunyai sifat jujur jika memang melanggar mengakui saja dan siap mendapatkan hukuman. Metode pendekatan penelitian kualitatif. Teknik pengumpulan datanya adalah observasi partisipan, wawancara atau interview mendalam, dan dokumentasi. Teknik analisis data yang digunakan adalah menganalisis data dilakukan dalam dua tahap, yaitu: (1) analisis data kasus individu, dan (2) analisis data lintas situs. Hasil penelitiannya adalah: Strategi pembelajaran kyai dalam membentuk karakter jujur santri di Pondok Pesantren Panggung Tulungagung dan Pondok Pesantren Hidayatul Mubtadiin Ngunut Tulungagung dilakukan dengan jalan: a) kyai memberikan kesadaran etika dengan mengajarkannya sebagaimana yang dalam kitab menuntun para santri untuk berkata benar, pengetahuan tentang etika berkata benar bahkan diajarkan mengendalikan diri. b) kyai mengajarkan pada santri untuk jujur dalam perkataan. c) Kyai memberikan pengarahan untuk membiasakan diri untuk berhenti berbohong.
Moment Aktaran ve Merkezi Çaprazlı Çok Katlı Çelik Yapıların 2018 Türkiye Bina Deprem Yönetmeliğine Göre Analizi ve Tasarımı (TBDY- 2018)
Authors: YILDIZHAN SAĞER Burcu , TEMEL Beytullah 
Published: January 2023

Bu çalışmada, moment aktaran ve merkezi çaprazlı çok katlı çelik yapıların 2018 Türkiye Bina Deprem Yönetmeliğine göre tasarımı yapılmıştır. 5 ve 10 katlı konut tipi binaların boyutlandırılmasında Çelik Yapıların Tasarım, Hesap ve Yapım Esaslarına Dair Yönetmeliği 2016 (ÇYTHYE-2016) ile Türkiye Bina Deprem Yönetmeliği (TBDY-2018) kullanılmıştır. 5 katlı yapıların doğrusal deprem yükü hesaplarında Eşdeğer Deprem Yükü Yöntemi, 10 katlı yapıların doğrusal deprem hesaplarında Mod Birleştirme Yöntemi kullanılmıştır. Yapılarda Yük ve Dayanım Katsayıları ile Tasarım (YDKT) yöntemine göre yük birleşimleri oluşturularak tasarım yapılmıştır. Süneklik düzeyi yüksek moment aktaran ve merkezi çaprazlı çelik çerçevelerden oluşan 5 ve 10 katlı binaların modellemesi ve yapısal analizlerinde SAP2000
v.20.0 paket programından faydalanılmıştır.
A review of urban rainwater harvesting in China
Authors: Zhou Jinjun , Pang Yali , Fu Guangtao , Wang Hao , Zhang Yongxiang , Memon Fayyaz Ali 
Published: January 2023

Abstract
Over the past 30 years, water security issue in Chinese cities has become increasingly serious, largely due to rapid urbanization, population growth and disproportionate investment in water infrastructure. Urban rainwater harvesting (URWH), a household and community-level rainwater management measure, has been widely used during this period. This study provides a critical review of the policies, methods, technology, construction, implementation and benefits related to URWH in China. We show that URWH in China has gone through three phases over the past 30 years: an initial development phase, a rapid development phase and a sponge city construction phase. URWH research has focused mainly on rainwater harvesting, storage, utilization, management and other technologies, with limited attention to policy and benefit analysis. However, the scale of URWH construction and implementation in China remains small and needs further development. Currently, while URWH assessments cover social, ecological and environmental benefits, the economic benefits need to be further strengthened. The next step in URWH implementation should be to strengthen research and development of policy, legal and design standards. This study provides guidance for the implementation of URWH in Chinese cities and other cities alike in developing countries.
Ligands for the Benzodiazepine Binding Site - a Survey
Authors: Teuber L. , Watjen F. , Jensen L.H. 
Published: January 2023

Abstract:
y-Aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian Central Nervous System (CNS). GABA participates in the 1·egulation of neuronal excitability through interaction with specific membrane proteins (the GABAA receptors). The binding of GABA to these postsynaptic receptors,
results in an opening of a chloride channel integrated in the receptor which allows the entry of c1- and
consequently leads to hyperpolarization of the recipient cell. The action of GABA is allosterically modulated by a wide variety of chemical entities which interact with distinct binding sites at the GABAA receptor complex. One of the most thoroughly investigated rnodulatory site is the benzodiazepin binding site. The benzodiazepines constitute a well-known class of therapeutics displaying hypnotic, anxiolytic and anticonvulsant effects. Their usefulness, however, is limited by a broad range of side effects comprising sedation, ataxia, amnesia, alcohol and barbiturate potentiation, tolerance development and abuse potential. Consequently, there has been an intensive search for modulatory agents with an improved profile, and a diversity of chemical entities distinct from the benzodiazepines. but with GABA modulatory effects have been identified. The existence of endogenous ligands for the GABAA receptor complex beside GABA has often been described, but their role in the regulation of GABA action is still a matter of controversy. The progress of molecular biology during the last decade has contributed enormously to the understanding of benzodiazepine receptor pharmacology. A total of 14 GABAA receptor subunits have been cloned from mammalian brain and have been expressed/co-expressed in stable cell lines. These transfected cells constitute an important tool in the characterization of subtype selective ligands. In spite of the rapidly expanding knowledge of the molecular and pharmacological mechanisms involved in GABA/benzodiazepine related CNS disorders. the identification of clinically selective acting drugs is still to come.
A Pharmacological Review of Competitive Inhibitors and Substrates of High-affinity, Sodium-dependent Glutamate Transport in the Central Nervous System
Authors: Bridges Richard J. , Kavanaugh Michael P. , Chamberlin A. Richard 
Published: January 2023

Abstract:
The acidic amino acid L-glutamate ucts as both a primary excitatory neurotransmitter and a potential neurotoxin within the mammalian central nervous system. Functionally juxtaposed between these neurophysiological and pathological actions are un assorted group of integral membrane transporter proteins that rapidly and efficiently sequester glutamate into cellular and subcellular compartments. While multiple systems exist that are capable of mediating the uptake or L-glutamate, the high-affinity, sodium-dependent transporters have emerged as the most prominent players in the CNS with respect to terminating the excitatory signal. recycling the transmitter, and regulating extracellular levels of glutamate below those which could induce excitotoxic pathology. The focus of the present review is on the pharmacological specificity of these sodium­ dependent transporters and, more specifically, on the competitive inhibitors that have been used to delineate the chemical requirements for binding and translocation. Anulogues of glutamate that are conformationally constrained as a consequence of either the addition of substituents to the carbon backbone of glutamate or aspartate (e.g., -hydroxyaspartate or methylglutamate derivatives) or the incorporation of ring systems (e.g., (carboxycyclopropyl)glycines, aminocyclobutane dicarboxylates, or pyrrolidine dicarboxylates), have been especially valuable in these efforts. In this review, a particular emphasis is placed on the identification of analogues that exhibit preferential activity among the recently cloned transporter subtypes and on the differentiation of substrates from non-transportable inhibitors.
A Perspective on Therapeutic Applications and Strategies to Mitigate Toxicity
of Metallic Nanoparticles
Authors: Karuppaiah Arjunan , Selvaraj Divakar , Sellappan Mohan , Nagarajan Arumugam , Babu Dinesh , Rahman Habibur , Madheswaran Thiagarajan , Bose Bharadhan , Natrajan Tamilselvan 
Published: January 2023

Abstract:
Metallic nanoparticles (MNPs) have been widely used for diagnostic and therapeutic purposes in clinical
practice. A number of MNP formulations are being investigated in clinical trials for various applications.
This increase in the use of NPs results in higher exposure to humans, leading to toxicity issues. Hence, it is necessary
to determine the possible undesirable effects of the MNPs after in-vivo application and exposure. One
of the main reasons for the toxicity of MNPs is the release of their respective metallic ions throughout the body.
Many research studies are in progress investigating the various strategies to reduce the toxicity of MNPs. These
research studies aim to change the size, dose, agglomeration, release, and excretion rates of MNPs. In this perspective
review, we discussed the possible strategies to improve the therapeutic effects of MNPs through various
processes, with lessons learned from the studies involving silver nanoparticles (AgNPs). We also discussed
the ways to manage the toxicity of MNPs by purification, surface functionalization, synergistic effect, and targeted
therapy approach. All these strategies could reduce the dose of the MNPs without compromising their
therapeutic benefits, which could decrease the toxicity of MNPs. Additionally, we briefly discussed the market
and toxicology testing for FDA-regulated MNPs.
Durable Resistance of Rice to Major and Emerging Diseases: Present Status
Authors: Bag Manas Kumar , Raghu S. , Banerjee Amrita , Prabhukarthikeyan S.R. , Baite Mathew S. , Yadav Manoj 
Published: January 2023

Background
Rice (Oryza sativa) is one of the most dominating cereal crop and half of the global people have chosen it as staple food. Rice production has increased significantly but the productivity is not increased significantly to combat the global need. One of the major constraints of low productivity is biotic stresses faced by rice growers. Some of the important biotic stresses of rice are major diseases like brown spot, bacterial blight, blast, sheath blight and, few emerging but significant diseases like false smut, bakanae and sheath rot play crucial role in reducing yield per unit area and quality of rice. Host plant resistance is the most effective, economic and eco-friendly approach of mitigating disease like biotic stress problem.

Objective
The objective of this review is to compile data related to resistance in rice against various major and emerging diseases as well as their application to develop gene pyramided varieties that increase resistance to those pathogens to achieve durable resistance.

Methods
Diseases are one of the most important constraints for sustainable or demanding production level as well as maintaining different quality parameters of the rice. Different management practices including majority by chemical means are not always solution as it add production cost many times vis-à-vis cause pollution in every aspect. Thus, development of durable resistant varieties are the best approaches.

Result
An array of robust molecular markers and genetic map of the crop has made application of marker assisted selection possible for the traits controlled by resistant genes or quantitative trait loci (QTLs) to induce durable resistance in the crop.

Conclusion
A comprehensive assessment on identification, sources and deployment of resistance genes/QTLs of major and emerging diseases of rice will help in development of varieties of rice with durable resistant to major and emerging disease-causing pathogens.
Evaluating the Impact of Mask Mandates and Political Party Affiliation on Mental Health Internet Search Behavior in the United States During the COVID-19 Pandemic: Generalized Additive Mixed Model Framework
Authors: Gyorda Joseph A , Lekkas Damien , Price George , Jacobson Nicholas C 
Published: January 2023

Background
The impacts of the COVID-19 pandemic on mental health worldwide and in the United States have been well documented. However, there is limited research examining the long-term effects of the pandemic on mental health, particularly in relation to pervasive policies such as statewide mask mandates and political party affiliation.

Objective
The goal of this study was to examine whether statewide mask mandates and political party affiliations yielded differential changes in mental health symptoms across the United States by leveraging state-specific internet search query data.

Methods
This study leveraged Google search queries from March 24, 2020, to March 29, 2021, in each of the 50 states in the United States. Of the 50 states, 39 implemented statewide mask mandates—with 16 of these states being Republican—to combat the spread of COVID-19. This study investigated whether mask mandates were associated differentially with mental health in states with and without mandates by exploring variations in mental health search queries across the United States. In addition, political party affiliation was examined as a potential covariate to determine whether mask mandates had differential associations with mental health in Republican and Democratic states. Generalized additive mixed models were implemented to model associations among mask mandates, political party affiliation, and mental health search volume for up to 7 months following the implementation of a mask mandate.

Results
The results of generalized additive mixed models revealed that search volume for “restless” significantly increased following a mask mandate across all states, whereas the search volume for “irritable” and “anxiety” increased and decreased, respectively, following a mandate for Republican states in comparison with Democratic states. Most mental health search terms did not exhibit significant changes in search volume in relation to mask mandate implementation.

Conclusions
These findings suggest that mask mandates were associated nonlinearly with significant changes in mental health search behavior, with the most notable associations occurring in anxiety-related search terms. Therefore, policy makers should consider monitoring and providing additional support for these mental health symptoms following the implementation of public health–related mandates such as mask mandates. Nevertheless, these results do not provide evidence for an overwhelming impact of mask mandates on population-level mental health in the United States.
Associations Between Modifiable Risk Factors and Changes in Glycemic Status Among Individuals With Prediabetes
Authors: Nabila Salma , Kim Ji Eun , Choi Jaesung , Park Jooyong , Shin Aesun , Lee Sang Ah , Lee Jong-Kook , Kang Daehee , Choi Ji-Yeob 
Published: January 2023

<p> </p>
<p>Objective: To examine the associations between modifiable risk factors and glycemic status changes in individuals with prediabetes.</p>
<p>Research design and methods: A total of 10,358 individuals with prediabetes defined by their fasting blood glucose and HbA1c levels from the Health Examinees-Gem (HEXA-G) study were included. Modifiable factors, including BMI, abdominal obesity, smoking status, physical activity, alcohol consumption, diet quality, hypertension, and dyslipidemia, were examined to determine their associations with changes in glycemic status during follow-up. In addition, modifiable factor scores were calculated, and their association with changes in glycemic status was also analyzed. </p>
<p>Results: The median follow-up time for this study was four years (range, one–seven years). BMI ≥25 kg/m2 (adjusted odds ratio 0.71 [95% confidence interval 0.63–0.79]), abdominal obesity (0.76 [0.68–0.86]), heavy drinking (0.74 [0.60–0.91]), hypertension (0.71 [0.64–0.79]), and dyslipidemia (0.78 [0.70–0.85]) were observed to have lower possibility of normoglycemia reversion. BMI ≥25 kg/m2 (1.58 [1.29–1.94]), abdominal obesity (1.31 [1.11–1.55]), current smoking (1.43 [1.07–1.91]), and hypertension (1.26 [1.07–1.49]) were found to have higher probability of type 2 diabetes progression. Having more favorable modifiable factors was also associated with normoglycemia reversion (1.46 [1.30–1.64]) and type 2 diabetes progression (0.62 [0.49–0.77]).</p>
<p>Conclusions: More favorable modifiable factors were related to a higher probability of returning to normoglycemia and a lower probability of progression to type 2 diabetes.</p>
TIC y educación superior en México: un análisis de productividad a nivel estatal
Authors: Becerra-Peña Diana L. , Rodríguez Ruiz Javier Gonzalo , Gutiérrez Moreno Patricia 
Published: January 2023

El objetivo de esta investigación fue analizar empíricamente los cambios en la productividad total de los factores (CPTF) del uso de las tecnologías de la información y la comunicación (TIC) en los principales indicadores de la educación superior durante 2010-2018 en México. Con un panel de 32 estados con información anual, se estimó el índice de Hicks-Moorsteen (HMTFP) para cada uno, bajo el supuesto de rendimientos variables a escala. Los resultados mostraron una caída promedio en los CPTF que oscila entre -5.09 % y 3.29 %, al considerar el desempeño conjunto de todas las entidades federativas. Se concluye que existe una imperativa necesidad de fortalecer la infraestructura de las TIC y su uso en el sector educativo, especialmente en el nivel superior.
Research on educational resource recommendation system based on MRLG Rec
Authors: Xie Xiaodan , Zhang Xinling 
Published: January 2023

Abstract
Internet information capacity is expanding and developing at a high speed every day. The huge amount of information data involves many problems, such as resources could be scattered, overlapped and confused and thus difficult for users to timely and accurately capture information suitable for them, especially in the field of education. Through the MRLG Rec algorithm, the following processes can be carried out: deep processing, characterisation of data to generate unique individual portraits of user information and to store education resource databases at the same time and analysis of recommendation system to provide users with more accurate high-quality education resources, thus forming a two-way unblocked and efficient information transmission closed-loop, which help learners find teaching resources of the time. It also has screening channels of high-quality educational resources. Through the analysis of experimental data, it is concluded that the algorithm improves the user viscosity of human-computer interaction in the teaching resource recommendation system.
U-Pb (LA-SF-ICP-MS) dating and probable provenance of detrital zircons from terrigenous deposits of the Upper Precambrian of the Subpolar Urals
Authors: Pystin A. M. , Grakova O. V. , Pystina Yu. I. , Kushmanova E. V. , Popvasev K. S. , Potapov I. L. , Khubanov V. B. 
Published: January 2023

Research subject. Upper Precambrian metaterrigenous deposits of the northern part of the Lyapinsky anticlinorium in the Subpolar Urals.Material and methods. From the metaterrigenous rocks of the Upper Precambrian section of different stratigraphic levels, monofractions of zircons were isolated and their optical and isotope-geochronological (U-Pb LA-SF-ICPMS) studies were performed.Results. Age boundaries of the formation of the Puivinskaya, Khobeinskaya, and Moroinskaya Formations in the Subpolar Urals were specified. A comparison was carried out of age populations of detrital zircons from metaterrigenous deposits of the Subpolar Urals and terrigenous sequences of adjacent regions similar in age. The age boundaries and the proposed location of crystalline complexes, the probable provenance areas of terrigenous material, were established.Conclusions. The lower age limit of the formation of the basal layers of the Upper Precambrian of the Subpolar Urals does not go beyond the Late Riphean. The north-eastern periphery of the East European Platform, including the Subpolar Urals, in the Late Precambrian belonged to the same continental margin, and the accumulation of the Middle-North Timan and Subpolar Ural Upper Riphean sediments occurred in the common sedimentation basin. The lower age boundary of the formation of the Puivinskaya Formation (about 1000 Ma) determines the probable formation time of the Timan passive margin.