bluuebunny/crossref_metadata_2025_split huggingface dataset:
Digital physiotherapy assessment vs conventional face-to-face physiotherapy assessment of patients with musculoskeletal disorders: A systematic review
Authors: Bernhardsson Susanne , Larsson Anette , Bergenheim Anna , Ho-Henriksson Chan-Mei , Ekhammar Annika , Lange Elvira , Larsson Maria E. H. , Nordeman Lena , Samsson Karin S. , Bornhöft Lena 
Published: March 2023

Background
This systematic review aimed to assess the certainty of evidence for digital versus conventional, face-to-face physiotherapy assessment of musculoskeletal disorders, concerning validity, reliability, feasibility, patient satisfaction, physiotherapist satisfaction, adverse events, clinical management, and cost-effectiveness.

Methods
Eligibility criteria: Original studies comparing digital physiotherapy assessment with face-to-face physiotherapy assessment of musculoskeletal disorders. Systematic database searches were performed in May 2021, and updated in May 2022, in Medline, Cochrane Library, Cinahl, AMED, and PEDro. Risk of bias and applicability of the included studies were appraised using the Quality Assessment of Diagnostic Accuracy Studies-2 tool and the Quality Appraisal of Reliability Studies tool. Included studies were synthesised narratively. Certainty of evidence was evaluated for each assessment component using GRADE.

Results
Ten repeated-measures studies were included, involving 193 participants aged 23–62 years. Reported validity of digital physiotherapy assessment ranged from moderate/acceptable to almost perfect/excellent for clinical tests, range of motion, patient-reported outcome measures (PROMs), pain, neck posture, and management decisions. Reported validity for assessing spinal posture varied and was for clinical observations unacceptably low. Reported validity and reliability for digital diagnosis ranged from moderate to almost perfect for exact+similar agreement, but was considerably lower when constrained to exact agreement. Reported reliability was excellent for digital assessment of clinical tests, range of motion, pain, neck posture, and PROMs. Certainty of evidence varied from very low to high, with PROMs and pain assessment obtaining the highest certainty. Patients were satisfied with their digital assessment, but did not perceive it as good as face-to-face assessment.

Discussion
Evidence ranging from very low to high certainty suggests that validity and reliability of digital physiotherapy assessments are acceptable to excellent for several assessment components. Digital physiotherapy assessment may be a viable alternative to face-to-face assessment for patients who are likely to benefit from the accessibility and convenience of remote access.

Trial registration
The review was registered in the PROSPERO database, CRD42021277624.
Association between urinary albumin creatinine ratio and cardiovascular disease
Authors: Kim Yoo Jin , Hwang Sang Won , Lee Taesic , Lee Jun Young , Uh Young 
Published: March 2023

Introduction
The association between microalbuminuria and cardiovascular disease (CVD) is accumulating in various patient populations. However, when stratified by sex, the relationship between microalbuminuria and CVD remains unclear.

Method
We obtained data from the 2011–2014 and 2019–2020 Korea National Health and Nutrition Examination Survey (KNHANES). Microalbuminuria was measured based on spot urine albumin-creatinine ratio (UACR). The Framingham risk score (FRS) model was implemented to evaluate the CVD risk. Linear and logistic regression models were used to identify the associations of microalbuminuria status with cardiometabolic predictors and CVD status determined by the FRS score.

Results
Among 19,340 representative Korean participants, the (UACR) in Korean women and men with history of CVD was higher than in those without history of CVD. Among patients without history of CVD, multivariate regression analysis showed that a high UACR was related to older age, lower high-density lipoprotein cholesterol level, higher total cholesterol level, higher systolic blood pressure, higher prevalence of current smoking, higher prevalence of diabetes, and higher anti-hypertensive medication use in both women and men. The UACR showed a positive linear correlation with the Framingham risk score in both women and men.

Conclusion
The presence of microalbuminuria was significantly associated with the cardiometabolic risk factors and the increased risk of CVD evaluated by FRS model in both women and men in a nationally representative sample of Korea.
Nanoteknologia Farmazeutikoaren Iraultza
Authors: Fidalgo Mayo Maria Luz 
Published: March 2023

LABURPENA: (250 hitz gehienez eta paragrafo batean)
Norio Taniguchi zientzialari japoniarrak 1974.urtean nanoteknologia hitza erabili eta definitu zuen lehengo aldiz. Handik geroztik, mikroskopio elektronikoaren aurrerapausoak bultzatuta, ohiz kanpokoa den teknologia berri honek gailendu besterik ez du egin. Nanoteknologia materia eskala atomikoan kontrolpean izatean datza eta bera erabilita etorkizunean gure bizitzako alderdi askotan izugarrizko garapena lortuko da. Azken urteotan medikuntza eta farmazia arloan ikerkuntza ugarik nanoteknologiaren abantailak aztertu dituzte eta egun emaitza ikusgarriak sorzen ari dira. Artikulu honetan haietariko batzuk aurkezten dira.
Recontando clássicos sob a perspectiva dos estudos de gênero
Authors: Gomes Fabiana de Oliveira , Pereira Diego Carlos 
Published: March 2023

Este artigo busca investigar as possíveis rupturas dos scripts de gênero nos livros da coleção infantil ‘A Revolução das Princesas’. A partir da análise realizada, é possível perceber que as obras questionam os padrões de gênero vigentes nas versões originais dos contos de fadas e, portanto, provocam rupturas na normatividade hegemônica.
PALAVRAS-CHAVE: Contos de Fadas. Literatura Infantil. Estudos Culturais. Estudos de Gênero.
Os desafios do home office e a maternidade em tempos de pandemia
Authors: Pacheco Isis Bruna Gomes , Pereira Russlana Rocha , Braga Iluska Lobo , Morais Fabio Rogerio de 
Published: March 2023

O estudo analisa conceitualmente os desafios do home office e da maternidade em tempos de pandemia. Foi realizada uma pesquisa qualitativa descritiva por meio de revisão sistemática da literatura sobre produções científicas relevantes acerca do tema.
PALAVRAS-CHAVE: Pandemia. Home-office. Maternidade. Motivação. Gênero.
Endovascular Aortic Repair for Thoracic Aortic Compression Resulting From Chance Fracture of the Thoracic Spine
Authors: Matsuo Akinobu , Matsuyama Sho , Kurisu Kazuhiro , Ueno Yasutaka , Oishi Yasuhisa , Shiose Akira 
Published: March 2023

Abstract
Blunt aortic injury is a serious condition with a high mortality rate. Although rare, blunt aortic injury associated with spinal fracture has also been reported, and appropriate management of aortic disease is key to a good outcome. This report is a case of a 78-year-old man who was found to have a transverse fracture (Chance fracture) in the ninth thoracic vertebra, with a sharp bone fragment compressing the thoracic aorta. Early spinal surgery was needed; however, there was concern about the possibility of bleeding from the aorta and surrounding small arteries associated with the bone fragment during spinal surgery. Therefore, thoracic endovascular aortic repair was performed before spinal surgery. The next day after thoracic endovascular aortic repair, posterior spinal instrumentation was performed, and the postoperative course was uneventful. Because aortic injury associated with vertebral fracture can lead to massive bleeding and spinal cord injury, endovascular repair before spinal surgery is reasonable.
Deficits and biases in the leading German press coverage of the Greek sovereign debt crisis
Authors: Teschendorf Victoria Sophie , Kruß Marwin , Otto Kim , Rusch Roman 
Published: March 2023

Abstract
In times of crisis and social turbulence, the mass media play a crucial role. This becomes particularly evident in economic crises within the European Union. The (biased) way the crisis is reported shapes people’s understanding of the crisis and the parties involved. In this study, the coverage of the Greek sovereign debt crisis in the German newspapers BILD, Die Welt, Frankfurter Allgemeine Zeitung, Süddeutsche Zeitung, tageszeitung and Der Spiegel (online) is examined for the quality criteria relevance, neutrality, balance, and analytical quality. The results show that the reporting is appropriate to the relevance of the topic, but shows deficits in the criteria of balance, neutrality, and analytical quality. During the study period, coverage focuses on a small number of topics, journalists include their value judgments in news and reports. Overall, there is an obvious media bias against the Greek government’s position.
Korrelation zwischen Eingangsparametern und der Performance für ein Miniatur-Fluoreszenzphotometer innerhalb einer Kleinserie
Authors: Müller Ralf , Hintz Michael , Neckermann Kristin , Krivanek Roland , Müller Achim 
Published: March 2023

Zusammenfassung
Diese Arbeit setzt sich mit der Entwicklung und die Einführung in die Serienfertigung eines miniaturisierten Fluoreszenzphotometers mit zwei Mess-Kanälen auseinander (Würfelzuckerformat). Die vorwiegende Anwendung wurde für ein faserbasiertes fluorometrisches Farbstoffsystem zur kontinuierlichen Blutzuckermessung realisiert. Ferner beschäftigt sich diese Arbeit mit der empirischen Bestimmung von bestimmten Toleranzangaben, die bei der Entwicklung selbst, die häufig mit Materialmangel verbunden war, nicht belastbar bestimmt werden konnten. Die Performance der Fluoreszenzphotometer ergibt sich einmal aus dem sogenannten internen Übersprechen, aus dem Verhältnis zwischen diesem internen Übersprechen und der Sensitivität sowie aus dem Verhältnis der Fluoreszenzsignale von Mess-Kanal eins und zwei (relative Fluoreszenz). Als Eingangsparameter wurden untersucht: (1) das Streulicht, welches von der sogenannten Beleuchtungseinheit ausgeht. (2) ein Optimierungsparameter, der bei der optisch aktiven Justage der Beleuchtungseinheit generiert wird. (3) der geometrische Versatz zwischen der Optik des Moduls und der „Ankoppelöffnung“ für den Multimode-Lichtwellenleiter. Zwischen (2) und der relativen Fluoreszenz konnte keine Korrelation nachgewiesen werden. Hier wurde über 206 Module bei einem Mittelwert von 6,68 für die relative Fluoreszenz eine Standardabweichung von 0,24 erreicht. Bezüglich (3) konnte bis zu einer Toleranz von ±100 μm keine Korrelationen zur Performance der Module festgestellt werden (141 Module). Dies kommt einer preiswerten Fertigung entgegen.
Plattformgenossenschaften: Perzeption und Diskurs im Kontext der Plattformökonomie - Einordnung anhand einer systematischen Literaturrecherche
Authors: Kaiser Philip , Balk Anselm , Schaffhauser-Linzatti Michaela 
Published: March 2023

Zusammenfassung
Die Plattformökonomie hat sich als irreversible Entwicklung im Austausch von Waren, Dienstleistungen und Informationen in der digitalen Welt etabliert. Anfangs als transparentes Instrument des direkten Kontaktes unter Ausschaltung von Intermediären und somit Transaktionskosten befürwortet, werden nun ihre Schattenseiten wie einseitige Marktmacht und Marktverzerrung sichtbar. Plattformgenossenschaften können aufgrund ihrer Konzeption eine Alternative darstellen. Um die akademische Rezeption der Möglichkeiten und Herausforderungen sowie die Abgrenzung der Plattformgenossenschaft zu gewinnmaximierenden Plattformunternehmen aufzuzeigen, widmet sich dieser Aufsatz anhand einer systematischen Literaturrecherche einer quantitativen und qualitativen Analyse in Hinblick auf wirtschaftliche, soziale und rechtliche Unterscheidungskriterien. Er stellt dabei gewinnmaximierende Plattformen den Plattformgenossenschaften gegenüber und ermöglicht dadurch sowohl eine Systematisierung des Verständnisses von Plattformgenossenschaften als auch ein Aufzeigen aktueller Forschungslücken.
Friedrich Niebergalls „Praktische Dogmatik“ – Eine Lektüre nach 100 Jahren
Authors: Henrik Boysen Knud 
Published: March 2023

Abstract
Der vorliegende Aufsatz untersucht aus systematisch-theologischer Sicht den von dem Heidelberger und Marburger Praktischen Theologen Friedrich Niebergall (1866–1932) zwischen ca. 1900 bis 1925 ausgeabeiteten Ansatz einer „Praktischen Dogmatik“. Niebergall wollte damit primär eine pastoraltheologisch orientierte Dogmatik entwickeln, die dem christlichen Prediger Handwerkszeug für seine „Erziehungsarbeit“ an der Gemeinde bereitstellt, mit deren Hilfe er die Gemeindeglieder zur Integration christlicher Ideale in die Pluralität ihres sozialen Alltags anleiten soll. Der Aufsatz unternimmt eine kritische Sichtung von theologischen Voraussetzungen, Inhalt, Aufbau und Folgen von Niebergalls Ansatz und stellt auch die Frage nach der Möglichkeit einer heutigen Adaption.
“Thanking God for the Humiliation”: Henry Scott Holland, British Idealism, and the Penitential Self
Authors: Norman Ralph 
Published: March 2023

Abstract
This paper provides a new reading of the theology of Lux Mundi (1889), emphasising the creative and constructive theological leadership of Henry Scott Holland (1847–1918). A wide range of works by Holland are examined, showing his resistance to the philosophical Idealism of Thomas Hill Green (1836–1882). This usefully illustrates ways in which Holland provided inspiration for later Anglican Social Theology. Holland’s influence on key trends in Anglican interpretation of doctrine, including theories of sin, penitence, forgiveness, atonement, and sacrifice are explored with reference to the moral climates of both the finde-siècle and the Great War (1914–1918).
Sound Improves Neuronal Encoding of Visual Stimuli in Mouse Primary Visual Cortex
Authors: Williams Aaron M. , Angeloni Christopher F. , Geffen Maria N. 
Published: March 2023

In everyday life, we integrate visual and auditory information in routine tasks such as navigation and communication. While concurrent sound can improve visual perception, the neuronal correlates of audiovisual integration are not fully understood. Specifically, it remains unclear whether neuronal firing patters in the primary visual cortex (V1) of awake animals demonstrate similar sound-induced improvement in visual discriminability. Furthermore, presentation of sound is associated with movement in the subjects, but little is understood about whether and how sound-associated movement affects audiovisual integration in V1. Here, we investigated how sound and movement interact to modulate V1 visual responses in awake, head-fixed mice and whether this interaction improves neuronal encoding of the visual stimulus. We presented visual drifting gratings with and without simultaneous auditory white noise to awake mice while recording mouse movement and V1 neuronal activity. Sound modulated activity of 80% of light-responsive neurons, with 95% of neurons increasing activity when the auditory stimulus was present. A generalized linear model (GLM) revealed that sound and movement had distinct and complementary effects of the neuronal visual responses. Furthermore, decoding of the visual stimulus from the neuronal activity was improved with sound, an effect that persisted even when controlling for movement. These results demonstrate that sound and movement modulate visual responses in complementary ways, improving neuronal representation of the visual stimulus. This study clarifies the role of movement as a potential confound in neuronal audiovisual responses and expands our knowledge of how multimodal processing is mediated at a neuronal level in the awake brain.SIGNIFICANCE STATEMENTSound and movement are both known to modulate visual responses in the primary visual cortex; however, sound-induced movement has largely remained unaccounted for as a potential confound in audiovisual studies in awake animals. Here, authors found that sound and movement both modulate visual responses in an important visual brain area, the primary visual cortex, in distinct, yet complementary ways. Furthermore, sound improved encoding of the visual stimulus even when accounting for movement. This study reconciles contrasting theories on the mechanism underlying audiovisual integration and asserts the primary visual cortex as a key brain region participating in tripartite sensory interactions.
Splicing factor YBX1 regulates bone marrow stromal cell fate during aging
Authors: Xiao Ye , Cai Guang‐Ping , Feng Xu , Li Yu‐Jue , Guo Wan‐Hui , Guo Qi , Huang Yan , Su Tian , Li Chang‐Jun , Luo Xiang‐Hang , Zheng Yong‐Jun , Yang Mi 
Published: March 2023

AbstractSenescence and altered differentiation potential of bone marrow stromal cells (BMSCs) lead to age‐related bone loss. As an important posttranscriptional regulatory pathway, alternative splicing (AS) regulates the diversity of gene expression and has been linked to induction of cellular senescence. However, the role of splicing factors in BMSCs during aging remains poorly defined. Herein, we found that the expression of the splicing factor Y‐box binding protein 1 (YBX1) in BMSCs decreased with aging in mice and humans. YBX1 deficiency resulted in mis‐splicing in genes linked to BMSC osteogenic differentiation and senescence, such as Fn1, Nrp2, Sirt2, Sp7, and Spp1, thus contributing to BMSC senescence and differentiation shift during aging. Deletion of Ybx1 in BMSCs accelerated bone loss in mice, while its overexpression stimulated bone formation. Finally, we identified a small compound, sciadopitysin, which attenuated the degradation of YBX1 and bone loss in old mice. Our study demonstrated that YBX1 governs cell fate of BMSCs via fine control of RNA splicing and provides a potential therapeutic target for age‐related osteoporosis.
pH regulates hematopoietic stem cell potential via polyamines
Authors: Kumar Sachin , Vassallo Jeffrey D , Nattamai Kalpana J , Hassan Aishlin , Karns Rebekah , Vollmer Angelika , Soller Karin , Sakk Vadim , Sacma Mehmet , Nemkov Travis , D'Alessandro Angelo , Geiger Hartmut 
Published: March 2023

AbstractUpon ex vivo culture, hematopoietic stem cells (HSCs) quickly lose potential and differentiate into progenitors. The identification of culture conditions that maintain the potential of HSCs ex vivo is therefore of high clinical interest. Here, we demonstrate that the potential of murine and human HSCs is maintained when cultivated for 2 days ex vivo at a pH of 6.9, in contrast to cultivation at the commonly used pH of 7.4. When cultivated at a pH of 6.9, HSCs remain smaller, less metabolically active, less proliferative and show enhanced reconstitution ability upon transplantation compared to HSC cultivated at pH 7.4. HSCs kept at pH 6.9 show an attenuated polyamine pathway. Pharmacological inhibition of the polyamine pathway in HSCs cultivated at pH 7.4 with DFMO mimics phenotypes and potential of HSCs cultivated at pH 6.9. Ex vivo exposure to a pH of 6.9 is therefore a positive regulator of HSC function by reducing polyamines. These findings might improve HSC short‐term cultivation protocols for transplantation and gene therapy interventions.
Evaluate the developmental competence of human 8-cell embryos by single-cell RNA sequencing
Authors: Wang Weizhou , Zhao Mengmeng , Zuo Haiyang , Zhang Jingyao , Liu Bin , Chen Fu , Ji Pengyun , Liu Guoshi , Gao Shuai , Shang Wei , Zhang Lu 
Published: March 2023

Graphical Abstract

Abstract
The transition of maternal to zygotic gene expression regulation is critical for human preimplantation embryo development. In recent years, single-cell RNA sequencing (scRNA-seq) had been applied to detect the factors that regulate human oocyte maturation and early embryo development. Here, the evaluation of transcriptomes in single blastomere from the embryo collected from patients by scRNA-seq was performed. There were 20 blastomeres biopsied from 8-cell embryos of seven patients who received more than two ART cycles due to low embryo competence. Meanwhile, ten cells were collected from 8-cell embryos of four patients who received ART treatment due to male or tubal factors. The blastomeres were then evaluated using the previously established scRNA-seq method to determine the associations between their gene expression and developmental competence. The total number of genes detected in 8-cell embryos that failed to form blastocyst including maternal and zygotic mRNAs was reduced. There were 324 differently expressed genes detected among the 8-cell embryos including 65 genes that were significantly suppressed in the 8-cell embryos that failed to form blastocyst. Further analysis found these 8-cell embryos arrested at the cleavage stage due to the dysfunction of the cell cycle, DNA transcription activity, histone methylation, and cell division-related genes such as SMCO-1, ZNF271P,ZNF679, ASF1b, BEX3, DPPA2, and ORC4. The alterations of gene expression detected in human 8-cell embryos are tightly associated with its developmental competence and could be used as targets to enhance embryo development or parameters to predict the embryo’s development outcomes.

Lay summary
Many females are suffering infertility due to the failure of embryonic development at early stages due to unknown causes. At the very beginning of human embryo development, the embryos start to express its own genes, which should be achieved at 8-cell stage. In current research, we isolated one cell from 8-cell embryos and detected the gene expression at single-cell level. Then the remaining cells of these embryos were cultured to form blastocyst. Meanwhile, the data was analyzed according to the outcomes of embryo development. We detected 324 differently expressed genes between the 8-cell embryos that succeeded and failed to form blastocyst. Our research showed the association between the gene expression and the developmental competence of 8-cell embryos. The findings could be used to predict the embryo quality and potential therapy target to improve the efficiency of assisted reproductive techniques.
II kasmetinė nacionalinė socialinės politikos konferencija „Gyvenimo kelias ir jo krizės: kaip (ar) veikia Lietuvos socialinė politika?“
Authors: Adomavičienė Aistė , Ambrazevičiūtė Kristina , Ankėnaitė-Balčiūnienė Kristina , Charenkova Jūratė , Dilytė-Kotenko Asta , Dunajevas Eugenijus , Jurėnienė Virginija , Purvaneckienė Giedrė , Lazutka Romas , Juška Arūnas , Straševičiūtė Žeimantė , Mataitytė-Diržienė Jurga , Šumskienė Eglė , Gevorgianienė Violeta , Genienė Rasa , Pocius Arūnas , Rapolienė Gražina , Gedvilaitė-Kordušienė Margarita , Tretjakova Vaida , Tamutienė Ilona , Auglytė Vaida , Zamalijeva Olga , Kairys Antanas , Zitikytė Kristina 
Published: March 2023

2022 m. spalio 14 d. Vilniaus universitete vyko II kasmetinė nacionalinė socialinės politikos konferencija „Gyvenimo kelias ir jo krizės: kaip (ar) veikia Lietuvos socialinė politika?“Universiteto g. 3, Vilniushttps://youtu.be/oBGfbjJijPY