bluuebunny/crossref_metadata_2025_split huggingface dataset:
Framing Person‐Centred Leadership in Residential Care: A Cross‐Cultural Adaptation of the Aged‐Care Clinical Leadership Qualities Framework
Authors: Backman Annica , Sundström Malin , Jeon Yun‐Hee , Edberg Anna‐Karin 
Published: January 2025

ABSTRACTAimTo cross‐culturally adapt a framework for person‐centred leadership in residential care for older people in Sweden.DesignThis study has an exploratory and descriptive design.MethodsThe translation procedure followed a cyclic process of translation into Swedish and back‐translation into English by two independent bilingual linguists. An evaluation of conceptual and semantic equivalence and comprehensiveness between the original English version and the translated Swedish version was performed by an expert committee. The translated version of the framework was validated by leaders (n = 34) in residential care, who assessed its relevance through a web form. The adaptation of the framework followed recommended guidelines for cross‐cultural adaptation.ResultsThe translation procedure resulted in two minor changes related to the wording in two descriptors. The results of the validation procedure showed that the framework is relevant for leaders in Swedish residential care for older people.ConclusionThe cross‐culturally adapted framework is useful and suitable for leaders in Swedish residential care for older people. The framework clarifies the leader's role and identifies leadership attributes and requirements for person‐centred leadership in residential care, thereby providing support to leaders by framing person‐centred leadership.Implications for the Profession and/or Patient CareThe framework can be used as a guide for leadership training and/or development initiatives in residential care. It can be further extended to nursing curriculums, leadership development programs, and organisational performance and development processes. It may also provide a foundation for policy and guidelines by establishing the activities required for leaders to promote person‐centredness in the care of older people.Reporting MethodThis study followed the STROBE checklist for cross‐sectional studies.Patient and Public ContributionThere was no patient or public contribution.
Challenges and opportunities in organ donation after circulatory death
Authors: Vidgren Mathias , Delorme Capucine , Oniscu Gabriel C. 
Published: January 2025

AbstractIn recent years, there has been resurgence in donation after circulatory death (DCD). Despite that, the number of organs transplanted from these donors remains low due to concerns about their function and a lack of an objective assessment at the time of donation. This overview examines the current DCD practices and the classification modifications to accommodate regional perspectives. Several risk factors underscore the reluctance to accept DCD organs, and we discuss the modern strategies to mitigate them. The advent of machine perfusion technology has revolutionized the field of DCD transplantation, leading to improved outcomes and better organ usage. With many strategies at our disposal, there is an urgent need for comparative trials to determine the optimal use of perfusion technologies for each donated organ type. Additional progress in defining therapeutic strategies to repair the damage sustained during the dying process should further improve DCD organ utilization and outcomes. However, there remains wide variability in access to DCD donation and transplantation, and organizational efforts should be doubled up with consensus on key ethical issues that still surround DCD donation in the era of machine perfusion.
Long‐term development in job crafting in employees with and without mental health issues during COVID‐19: The role of job resources
Authors: Lehmann Anja I. , Kerksieck Philipp , Bauer Georg F. 
Published: January 2025

AbstractThe aim of this study was to investigate long‐term development in job crafting during the COVID‐19 pandemic among employees with and without mental health issues (MHI). Furthermore, this study aimed to explore the role of job resources regarding these changes. We have analysed longitudinal panel data of six waves between 2019 (applied as pre‐pandemic baseline) and 2022 from employees in Switzerland, Germany and Austria. Hierarchical linear modelling showed change differences in job crafting: employees with MHI experienced a higher decrease in job crafting during the COVID‐19 pandemic compared with employees without MHI. When investigating the specific crafting dimensions, we found that there was a group difference only for crafting for structural resources, but not for crafting for social resources. Moreover, job resources buffered the decrease in job crafting among employees with MHI. Particularly, social support buffered the decrease in crafting for social resources and role clarity buffered the decrease in crafting for structural resources. These results suggest that in times of crisis, strengthening job resources can help employees with MHI maintain their job crafting behaviour.
Identifying High‐Risk Patients for Paediatric Unplanned Readmissions: Insights From a Western Sydney Hospital
Authors: Wraight Owen , Sadulla Huma , Low Gary , Liu Anthony , Bhurawala Habib 
Published: January 2025

ABSTRACTAimTo identify factors and diagnoses associated with unplanned readmission of paediatric patients to a Western Sydney metropolitan hospital.MethodA retrospective cross‐sectional study on paediatric patients admitted to a non‐tertiary hospital in Western Sydney from January 2017 to December 2022. Multivariate modelling was used to determine demographic factors and diagnoses associated with unplanned readmission.Results1334 (6.3%) of 21 262 admissions had an unplanned readmission within 28 days of the initial admission. Being First Nations had an OR of 1.31 (95% CI 1.11–1.54), while each additional day of admission had an OR of 1.05 (95% CI 1.03–1.07). Increasing age had an OR of 0.95 (95% CI 0.93–0.96) per year, and those admitted during the COVID pandemic had an OR of 0.61 (95% CI 0.54–0.69). A diagnosis of diabetes was found to have an OR of 2.36 (95% CI 1.45–3.84) and bronchiolitis an OR of 1.9 (95% CI 1.53–2.36), whereas a diagnosis of injury had an OR of 0.76 (95% CI 0.58–0.99) and otitis media an OR of 0.23 (95% CI 0.11–0.49).ConclusionsBeing First Nations and having a longer length of stay increased the likelihood of unplanned readmission in paediatric patients, while older age and admission during the COVID pandemic decreased the likelihood. A diagnosis of diabetes or bronchiolitis, among others, increased the likelihood of unplanned readmission. Conversely, a diagnosis of injury or otitis media decreased the likelihood of unplanned readmission. This lays the groundwork for further research and targeted interventions to reduce unplanned readmissions and associated costs.
Intellectual property rights as private rights: Implications of the theory of internally limited rights and incentive theory for reconstructing the normative content of rights in intangible goods
Authors: Gliściński Konrad 
Published: January 2025

AbstractThe article examines the normative content and justification of intellectual property rights (IPR), focusing on the question of whether the incentive theory provides a sufficient and appropriate basis for the regulation of intangible goods within the framework of the concept of inherently limited rights. The research method is based on theoretical analysis conducted within the framework of Civil Law Policy. The first part of the article compares two approaches to limiting rights, including exceptions and limitations related to intellectual property. The first approach assumes that rights are restricted only in cases of conflict with other rights. In contrast, the second approach, Marmora's concept of inherently limited rights, posits that rights are subject to both external and internal limitations through prior analysis of costs and benefits (ex ante). Adopting the second approach leads to the conclusion that intellectual property rights should be treated as inherently limited by a system of exceptions and limitations. This perspective supports the principle of the public domain, which holds that exclusive rights are exceptions to the general rule of the widespread availability of intangible goods and must be designed and applied in accordance with the principle of proportionality. The second part of the article critically evaluates the incentive theory as a tool for justification and conducting ex‐ante analysis. This theory is inadequate as a foundation for regulating intangible goods. Firstly, it erroneously assumes that exclusive rights are a causally necessary condition for the creation of works and technological progress. Furthermore, it overlooks the importance of non‐market transactions and the role of the state in the creation of intangible goods, relying instead on the premise that the market is the primary or sole mechanism for social organization. The incentive theory also disregards alternative means of appropriating benefits from intangible goods within market transactions and fails to consider the micro‐ and macroeconomic inefficiencies resulting from granting exclusive rights. From this perspective, the article serves as a critique of the current system of regulating intangible goods through exclusive rights justified by the incentive theory. At the same time, it advocates for the development of a more comprehensive and balanced regulatory model that considers both the interests of creators and societal needs. Particularly promising are regulatory models based on non‐exclusive rights, which, while ensuring remuneration for creators, simultaneously provide broad access to intangible goods for society.
Serial Position Bias Among Experts: Evidence From a Cooking Competition Show
Authors: Reimão Maira Emy , Sabbadini Rachel , Rego Eric 
Published: January 2025

ABSTRACTThe Great British Bake Off is a popular amateur cooking competition show, and its design offers an opportunity for analyzing serial position bias among expert rankings. In this paper, we use the technical challenge portion of the show to assess whether experts—in this case, the judges in the show—are susceptible to primacy or recency effects. We find that expert judges favor the first dish tasted in a blind test and that this pattern holds not only among judges of the British version of the show but also in other English‐speaking versions. We do not find evidence of a recency effect. Our results indicate that expert assessments, regularly used in markets, are vulnerable to bias even when there are no financial incentives.
Iron and copper sulfides in asteroid (162173) Ryugu: Formation conditions and a comparison to the CI and CY chondrites
Authors: Harrison C. S. , King A. J. , Jones R. H. , Russell S. S. , Nakamura T. , Yurimoto H. , Noguchi T. , Okazaki R. , Yabuta H. , Naraoka H. , Sakamoto K. , Tachibana S. , Yada T. , Nishimura M. , Nakato A. , Miyazaki A. , Yogata K. , Abe M. , Okada T. , Usui T. , Yoshikawa M. , Saiki T. , Tanaka S. , Terui F. , Nakazawa S. , Watanabe S. , Tsuda Y. 
Published: January 2025

AbstractJAXA's Hayabusa2 sample return mission visited the volatile‐rich carbonaceous (C‐type) asteroid (162173) Ryugu with the aim of ground‐truthing remote observations, returning a pristine sample from a C‐type asteroid, and strengthening links between asteroids and the meteorite collection. Here, we have conducted a systematic study of coarse (>10 μm) sulfide grains in Ryugu particles C0025‐01 and C0103‐02, the CI chondrites Orgueil and Ivuna, and the CY chondrites Y‐86029 (Stage III, heated to 500–750°C) and Y‐86720 (Stage IV, >750°C), using scanning electron microscopy (SEM) and electron probe microanalysis (EPMA). Sulfides are sensitive tracers of secondary alteration conditions, and we find that Ryugu and the CI chondrites share a distinct sulfide assemblage that includes the iron sulfides pyrrhotite and pentlandite, and the copper sulfide cubanite, that equilibrated during periods of low temperature (~25°C) aqueous alteration. Sulfides in the CY chondrites are compositionally distinct from Ryugu and the CI chondrites as a result of post‐hydration heating. However, the occurrence of Cu‐rich sulfides in Ryugu, the CIs, and the CYs suggests a genetic relationship between these samples.
A Systematic Targeted Genetic Screen Identifies Proteins Involved in Cytoadherence of the Malaria Parasite P. falciparum
Authors: Küster Nina , Roling Lena , Ouayoue Ardin , Steeg Katharina , Przyborski Jude M. 
Published: January 2025

ABSTRACTImmediately after invading their chosen host cell, the mature human erythrocyte, malaria parasites begin to export an array of proteins to this compartment, where they initiate processes that are prerequisite for parasite survival and propagation, including nutrient import and immune evasion. One consequence of these activities is the emergence of novel adhesive phenotypes that can lead directly to pathology in the human host. To identify parasite proteins involved in this process, we used modern genetic tools to target genes encoding 15 exported parasite proteins, selected by an in silico workflow. This resulted in four genetically modified parasite lines that were then characterised in detail. Of these lines, three could be shown to have aberrations in adhesion, and of these one appears to have a block in the transport and/or correct folding of the major surface adhesin PfEMP1 (Plasmodium falciparum erythrocyte membrane protein 1). Our data expand the known factors involved in this important process and once again highlight the complexity of this phenomenon.
Multi‐omics analysis identified the GmUGT88A1 gene, which coordinately regulates soybean resistance to cyst nematode and isoflavone content
Authors: Jiang Haipeng , Qu Shuo , Liu Fang , Sun Haowen , Li Haiyan , Teng Weili , Zhan Yuhang , Li Yongguang , Han Yingpeng , Zhao Xue 
Published: January 2025

SummarySoybean cyst nematode (SCN, Heterodera glycines) is a major pathogen harmful to soybean all over the world, causing huge yield loss every year. Soybean resistance to SCN is a complex quantitative trait controlled by a small number of major genes (rhg1 and Rhg4) and multiple micro‐effect genes. Therefore, the continuous identification of new resistant lines and genes is needed for the sustainable development of global soybean production. Here, a novel disease‐resistance quantitative trait locus Rscn‐16 was identified and fine mapped to an 8.4‐kb interval on chromosome 16 using an F2 population. According to transcriptome and metabolome analysis, a UDP‐glucosyltransferase encoding gene, GmUGT88A1, was identified as the most likely gene of Rscn‐16. Soybean lines overexpressing GmUGT88A1 exhibited increased resistance to SCN, higher isoflavone glycosides and larger seed size while the phenotype of RNA‐interference and knockout soybean lines showed sensitivity to SCN and decreased in seed size compared to wild‐type plants. GmMYB29 gene could bind to the promoter of GmUGT88A1 and coordinate with GmUGT88A1 to regulate soybean resistance to SCN and isoflavone accumulation. Under SCN infection, GmUGT88A1 participated in the reorientation of isoflavone biosynthetic metabolic flow and the accumulation of isoflavone glycosides, thus protecting soybean from SCN stress. GmUGT88A1 was found to control soybean seed size by affecting transcription abundance of GmSWEET10b and GmFAD3C, which are known to control soybean seed weight. Our findings provide insights into the regulation of SCN resistance, isoflavone content and seed size through metabolic flux redirection, and offer a potential means for soybean improvement.
ICE1 (Inducer of CBF Expression 1) Is Essential for the Jasmonate‐Regulated Development of Stamen in Arabidopsis thaliana
Authors: Li Yuke , Xu Jinfeng , Xu Man , Yang Yunxiao , Cheng Ying , Shang Zhonglin , Kang Erfang 
Published: January 2025

ABSTRACTFloral organ development, pollen germination and pollen tube growth are crucial for plant sexual reproduction. Phytohormones maintain these processes by regulating the expression and activity of various transcription factors. ICE1, a MYC‐like bHLH transcription factor, has been revealed to be involved in cold acclimatisation of Arabidopsis. This study shows that ICE1 regulates multiple aspects of sexual reproduction, including stamen development, pollen development and germination. Loss‐of‐function mutants of ICE1 exhibit floral organs with shorter filaments, defective anther dehiscence and lower pollen viability compared to the wild type. These abnormalities result in disrupted fertilisation, leading to short siliques, a high rate of seed abortion, and dark, shriveled mature seeds. JAZ proteins (JAZ1 and JAZ9) interact with ICE1, inhibiting its transcriptional activity on jasmonic acid (JA)‐responsive genes, including MYB21, MYB24 and MYB108. This study highlights the essential role of ICE1 as a signalling agent in the JA‐regulated maintenance of sexual reproduction in Arabidopsis thaliana.
Photobiomodulation therapy in diabetes: Benefits for pain relief, quality of life, and wound healing
Authors: da Silva Oliveira Victória Regina , de Paula Oliveira Inaeh , Alonso‐Matielo Heloísa , Oliveira Victhor Teixeira , Kremer Jean Lucas , Casalverini Milena Cristina Dias , Ribeiro Fernando Quadros , Maria‐Engler Silvya Stuchi , Assis Silvia Romano , Teixeira Manoel Jacobsen , Lotfi Claudimara Ferini Pacicco , Otoch José Pinhata , Dale Camila Squarzoni 
Published: January 2025

AbstractGlobally, 537 million people suffer from diabetes mellitus (DM), a condition often associated with sensory disturbances, wound development, and chronic pain, which significantly affects the quality of life and imposes a substantial economic burden. This study evaluated the effects of photobiomodulation (PBM) therapy on nociceptive and sensory changes in diabetic patients to understand pain manifestations and explore PBM's molecular mechanisms on wound healing. Twenty patients with type 2 DM underwent clinical assessments, completed pain and quality of life questionnaires, and had their pain sensitivity evaluated using the quantitative sensory test (QST). A 5 mm skin biopsy was taken for fibroblast culture. PBM therapy, using 660 nm red light, was administered twice weekly for 7 weeks on lower limb wounds. Results indicated that DM patients faced significant sensory impairments, impacting their quality of life. PBM therapy improved pain scores, alleviated neuropathic pain, and enhanced sensory function, leading to better quality of life and reduced anxiety and depression. It also accelerated wound healing, enhancing mobility and autonomy. In vitro studies showed PBM therapy increased cell proliferation through the ERK signaling pathway and modulation of matrix metalloproteinases (MMP‐1/8 and 2) and tissue inhibitors of metalloproteinases (TIMP).
Subsidizing Unprofitable Industries: The Political Determinants of Agro‐Industrial Policy in French Overseas Departments
Authors: Joltreau Thibaut 
Published: January 2025

ABSTRACTWhy do states subsidize unprofitable industries? This paper applies the Programmatic Action Framework and adapts it to neocorporatist settings to uncover the political determinants of industrial policies. Empirically, it explores how a longstanding coalition of economic, administrative and political actors has maintained public funding for the sugarcane agro‐industry in French overseas departments, despite new policy objectives for agricultural diversification and subsidy reallocation. Drawing on extensive archival and interview data, I argue that this tripartite programmatic group has leveraged long‐term institutionalized structures to resist subsidy reform and secure support for sugarcane production. Through coordinated discursive strategies to counter “transformative” policy proposals, and relational tactics to exclude challenging actors from the policy venue, each subgroup of this coalition has preserved its social position and the associated political resources gained from policymaking. These findings suggest that innovative policy reform in such sectors will require new public‐private alliances capable of challenging entrenched programmatic groups.
Red blood cell urate levels are linked to hemolysis in vitro and post‐transfusion as a function of donor sex, population and genetic polymorphisms in SLC2A9 and ABCG2
Authors: Key Alicia M. , Earley Eric J. , Tzounakas Vassilis L. , Anastasiadi Alkmini T. , Nemkov Travis , Stephenson Daniel , Dzieciatkowska Monika , Reisz Julie A. , Keele Gregory R. , Deng Xutao , Stone Mars , Kleinman Steve , Hansen Kirk C. , Norris Philip J. , Busch Michael P. , Roubinian Nareg H. , Page Grier P. , D'Alessandro Angelo 
Published: January 2025

AbstractBackgroundStorage of packed red blood cells (RBCs) for transfusion leads to biochemical and morphological changes, increasing hemolysis risk. Urate levels in blood bags at donation contribute to the molecular heterogeneity and hemolytic propensity of stored RBCs. However, studies to date have been underpowered to investigate at scale the contribution of donor demographics and genetics to the heterogeneity in urate levels across donations.Study Design and MethodsUrate levels were measured in 13,091 RBC units from the REDS study. Characteristics tested included hemolysis parameters (spontaneous, osmotic, oxidative) at storage end and post‐transfusion hemoglobin (Hb) increments in recipients. Donor demographics, urate levels, and genetic variants were analyzed for associations with these outcomes.ResultsElevated urate levels were linked to male sex, older age, high BMI, and Asian descent. Units with high urate levels exhibited increased spontaneous and osmotic hemolysis, while oxidative hemolysis was unaffected. Genetic variants in SLC2A9 (V282I) and ABCG2 (Q141K) were strongly associated with elevated urate, particularly in Asian donors. Post‐transfusion analyses revealed that units from female donors carrying these variants were associated with reduced Hb increments, with up to a 31% reduction in efficacy. This effect was not observed in male donors.DiscussionRBC urate levels and genetic traits significantly impact storage quality and transfusion outcomes. These findings highlight the importance of donor molecular characteristics for optimizing transfusion strategies. Moreover, genetic and metabolic insights may inform donor recruitment efforts, providing health feedback to volunteers while ensuring effective transfusion products.
Artificial intelligence and transfusion education, research and practice: The view from the ISBT Clinical Transfusion Working Party
Authors: Al‐Riyami Arwa Z. , Gammon Richard R. , Seheult Jansen , Arora Satyam , Goel Ruchika 
Published: January 2025

AbstractBackground and ObjectivesArtificial intelligence (AI) has been gaining increasing interest in healthcare. During the 2024 International Society of Blood Transfusion (ISBT) Congress, the Clinical Transfusion Working Party (CTWP) conducted a session to explore the exciting intersection of AI in transfusion medicine (TM) practice, education and research. We report here the potential applications and the session outcome.Materials and MethodsA pre‐workshop survey explored the participants' demographics and areas of use of AI and whether they have had any AI‐specific training or education. The workshop included presentations on the regulatory aspects of AI use and its application in TM practice, education and research. These were followed by round‐table discussions to explore participants' experience and concerns.ResultsThe workshop had 72 attendees, with 38% falling in the 36–45‐year age group. A total of 70% indicated the use of AI, but only 12% reported having specific training or education. Participants expressed interest in different potential applications but also shared concerns on over‐reliance, potential loss of skills, the accuracy of provided information and content plagiarism.ConclusionThe findings of the workshop highlight the need for training, educational resources, standards and regulatory frameworks to guide the use of AI tools in the field of TM.