bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sanguinarine triggers apoptosis in cutaneous squamous cell carcinoma cells through ROS-dependent JNK-kinase signaling
Authors: Patil Kalyani , Khan Abdul , Ahmad Fareed , Kuttikrishnan Shilpa , Anver Rasheeda , Mateo Jericha M. , Ahmad Aamir , Bhat Ajaz , Buddenkotte Joerg , Steinhoff Martin , Uddin Shahab 
Published: July 2023

Abstract
Cutaneous Squamous Cell Carcinoma (cSCC), the second most common non-melanoma skin cancer, originates from the malignant transformation of atypical epidermal keratinocytes. In recent decades, contemporary research has widened our comprehension of the molecular pathogenesis of cSCC, propelling the evolution of effective therapies in the management of cSCC. Sanguinarine (Sng), a quaternary benzophenanthridine alkaloid, is a multifaceted natural agent. In consideration of its potent anti-neoplastic activity, the present study evaluated the in vitro cytotoxicity of Sng against primary (A431) and metastatic (A388) cSCC cells and delineated its underlying molecular mechanisms. Treatment with Sng significantly inhibited cell proliferation by inducing sub-G0/G1 cell-cycle arrest and apoptosis in cSCC cells. Sng evoked reactive oxygen species (ROS) generation, intracellular glutathione (GSH) depletion, mitochondrial transmembrane potential (ΔΨm) depolarization, and the activation of the JNK pathway as well as that of caspase-3, -8, -9, and PARP. Application of the antioxidant N-acetyl cysteine (NAC) inhibited ROS production, replenished GSH levels, and abolished the apoptosis induced by Sng via downregulating JNK. Our results also showed that z-VAD-FMK, a pan-caspase inhibitor, efficiently blocked cell death induced by Sng. Moreover, pharmacological inhibition of JNK by SP600125 mitigated Sng-induced apoptosis. Finally, Sng ablated the stemness potential in metastatic cSCC cell-derived spheroids. Cumulatively, this investigation revealed that Sng triggers apoptosis in cSCC cells through ROS- dependent activation of the MAPK signaling pathway, thus suggesting its therapeutic potential.
A Study of the Students’ Reading Competency in the Junior High School Based on the 2013 Curriculum
Authors: Arcana Yasa I Putu Budi , Tantra Dewa Komang , Suputra Putu Eka Dambayana 
Published: July 2023

Students’ reading abilities were below of minimum mastery criteria. This study was conducted to describe and analyze the students’ reading competency at junior high school level. The significance was to design and develop reading modular instructions with explicit reading strategies. This study was designed quantitatively. The students’ reading competency was measured quantitatively using a reading competency test. The test consisted of 25 multiple choice items with four options. The obtained data were analyzed quantitatively in two steps, namely: descriptive and inferential analysis. The mean scores of the students’ reading competency based on the reading indicators. The research findings were the mean score of the students’ reading competency in class D was 63.20 and in class H was 36.80. The range score between class D and H was same for descriptive text. However, for recount text, the score in class D was larger than class H. Comparing to class H, the score variability in class D was larger for descriptive text and lower for recount text. The EFL teachers are suggested to use the appropriate reading strategies and materials which can encourage the students for following fun reading activity in the classroom.
COOPERATIVE LEARNING MODEL TYPE STAD: HOW DOES IT’S IMPACT ON STUDENTS KNOWLEDGE ABOUT HEAT AND TEMPERATURE
Authors: Rusma Olyivia Retdwina , Oktavia Rani 
Published: July 2023

One of the subjects that plays an important role in the development of the times is science. Science subjects aim to equip students with knowledge related to everyday life and train them to think scientifically. Therefore the call for learning objectives in science is something that needs to be prioritized by the teacher. One of the steps that can be taken by the teacher is to apply a learning model that is in accordance with the characteristics of the material in science subjects. One model that can be applied by teachers is the STD type of cooperative learning model. The purpose of this study was to see the effect of the STAD type cooperative learning model on students' cognitive learning outcomes on temperature, heat and expansion of SMPN 28 Padang.This research is a type of quasi-experimental research with nonequivalent control group research design. The sample in this study used a purposive sampling technique. Statistical analysis in this study used SPSS version 25. Based on the hypothesis test, a significance value of 0.735 was obtained, which means that there was no effect of the STAD type cooperative learning model on students' cognitive learning outcomes on temperature, heat, and expansion for class VII SMPN 28 Padang. There are several inhibiting factors on students' cognitive learning outcomes including student character, student interest in learning, various student backgrounds, students' basic mathematical abilities and model adjustments that have just been implemented at SMPN 28 Padang.
Pedicle subtraction metallectomy with complex posterior reconstruction for fixed cervicothoracic kyphosis: illustrative case
Authors: Chopra Harman , Orenday-Barraza José Manuel , Braley Alexander E. , Guiroy Alfredo , Gilbert Olivia E. , Galgano Michael A. 
Published: July 2023

BACKGROUND
Iatrogenic cervical deformity is a devastating complication that can result from a well-intended operation but a poor understanding of the individual biomechanics of a patient’s spine. Patient factors, such as bone fragility, high T1 slope, and undiagnosed myopathies often play a role in perpetuating a deformity despite an otherwise successful surgery. This imbalance can lead to significant morbidity and a decreased quality of life.

OBSERVATIONS
A 55-year-old male presented to the authors’ clinic with a chin-to-chest deformity and cervical myelopathy. He previously had an anterior C2–T2 fixation and a posterior C1–T6 instrumented fusion. He subsequently developed screw pullout at multiple levels, so the original surgeon removed all of the posterior hardware. The T1 cage (original corpectomy) severely subsided into the body of T2, generating an angular kyphosis that eventually developed a rigid osseous circumferential union at the cervicothoracic junction with severe cord compression. An anterior approach was not feasible; therefore, a 3-column osteotomy/fusion in the upper thoracic spine was planned whereby 1 of the T2 screws would need to be removed from a posterior approach for the reduction to take place.

LESSONS
This case highlights the devastating effect of a hardware complication leading to a fixed cervical spine deformity and the complex decision making involved to safely correct the challenging deformity and restore function.
PENGUASAAN GURU TERHADAP MEDIA PEMBELAJARAN BAHASA
Authors: Sylvia Novi , Saptawuryandari Nurweni , Zabadi Fairul 
Published: July 2023

This paper presents research results on teachers' mastery of language learning media. Studies on Indonesian language and digital media are uncommon. Meanwhile, the latest score for the Indonesian language national examination and the map of Indonesian language proficiency in all provinces in Indonesia showed unsatisfactory results. This study examines the teachers' mastery of language learning media and its effect on student learning outcomes. The approach used is quantitative. The instruments are (1) tests that are arranged based on the appropriateness principle of learning media, (2) questionnaires on teachers’ mastery of language learning media, and (3) documents of students' scores in the Indonesian language subject. The validity of instruments was tested through expert judgment. The analysis results show that teachers master the language learning media. Hence, the Indonesian language national examination results are not due to teachers’ mastery of the learning media. As suggestions, the assessment of students' Indonesian learning outcomes in schools can be measured using the Indonesian Language Competency Test (UKBI), which includes the language skills needed in the digital era. AbstrakTulisan ini merupakan hasil penelitian tentang penguasaan guru terhadap media pembelajaran bahasa. Penelitian terkait pembelajaran bahasa Indonesia pada media digital masih jarang ditemukan. Sementara itu, nilai ujian nasional bahasa Indonesia periode terakhir dan peta kemahiran berbahasa Indonesia di seluruh provinsi di Indonesia menunjukkan hasil yang tidak memuaskan. Penelitian ini bertujuan untuk melihat penguasaan guru terhadap media pembelajaran bahasa dan pengaruhnya terhadap hasil pembelajaran siswa. Pendekatan yang digunakan adalah kuantitatif. Instrumen yang digunakan berupa (1) tes yang disusun berdasarkan prinsip kesesuaian media pembelajaran, (2) angket penguasaan guru terhadap media pembelajaran bahasa, serta (3) dokumen nilai siswa pada mata pelajaran bahasa Indonesia. Validitas instrumen diuji melalui uji pakar dosen sekaligus praktisi. Hasil analisis menunjukkan bahwa penguasaan guru terhadap media pembelajaran bahasa sudah baik dan hasil ujian nasional bahasa Indonesia tidak dipengaruhi oleh penguasaan guru terhadap media pembelajaran. Sebagai saran, penilaian hasil pembelajaran bahasa Indonesia siswa di sekolah dapat diukur dengan menggunakan Uji Kompetensi Bahasa Indonesia (UKBI) yang telah mencakupi keahlian berbahasa yang dibutuhkan di era digital.
Plasma Phosphorylated Tau181 and Amyloid-β42 in Dementia with Lewy Bodies Compared with Alzheimer’s Disease and Cognitively Healthy People
Authors: Yu Yueyi , Xia Xinyi , Meng Xiaosheng , Li Dan , Qin Qi 
Published: July 2023

Background: Increasing evidence illustrates the value of plasma biomarkers of Alzheimer’s disease (AD) to screen for and identify dementia with Lewy bodies (DLB). However, confirmatory studies are needed to demonstrate the feasibility of these markers. Objective: To determine the feasibility of plasma tau phosphorylated at threonine 181 (p-tau181) and amyloid-β42 (Aβ42) as potential biomarkers to differentiate AD and DLB. Methods: We evaluated plasma samples from patients with DLB ( n = 47) and AD ( n = 55) and healthy controls (HCs, n = 30), using ELISAs to measure p-tau181 and Aβ42. Additionally, we examined neuropsychological assessment scores for participants. The plasma biomarkers were investigated for correlation with neuropsychological assessments and discriminant ability to identify DLB. Results: Plasma p-tau181 was significantly lower in DLB than in AD and HCs. Plasma Aβ42 was significantly higher in DLB than in AD but lower in DLB than in HCs. We found good correlations between plasma Aβ42 and neuropsychological scores in the whole cohort, while p-tau181 was associated with cognitive status in DLB. In the distinction between DLB and HCs, plasma p-tau181 and Aβ42 showed similar accuracy, while Aβ42 showed better accuracy than p-tau181 in discriminating DLB and AD. Conclusion: In a single-center clinical cohort, we confirmed the high diagnostic value of plasma p-tau181 and Aβ42 for distinguishing patients with DLB from HCs. Plasma Aβ42 improved the differential diagnosis of DLB from AD.
Shanghai Cognitive Screening: A Mobile Cognitive Assessment Tool Using Voice Recognition to Detect Mild Cognitive Impairment and Dementia in the Community
Authors: Huang Lin , Li Yatian , Wu Jingnan , Chen Nan , Xia Huanhuan , Guo Qihao 
Published: July 2023

Background: A rapid digital instrument is needed to facilitate community-based screening of mild cognitive impairment (MCI) and Alzheimer’s disease (AD) in China. Objective: We developed a voice recognition-based cognitive assessment (Shanghai Cognitive Screening, SCS) on mobile devices and evaluated its diagnostic performance. Methods: Participants (N = 251) including healthy controls (N = 98), subjective cognitive decline (SCD, N = 42), MCI (N = 80), and mild AD (N = 31) were recruited from the memory clinic at Shanghai Sixth People’s Hospital. The SCS is fully self-administered, takes about six minutes and measures the function of visual memory, language, and executive function. Participants were instructed to complete SCS tests, gold-standard neuropsychological tests and standardized structural 3T brain MRI. Results: The Cronbach’s alpha was 0.910 of the overall scale, indicating high internal consistency. The SCS total score had an AUC of 0.921 to detect AD (sensitivity = 0.903, specificity = 0.945, positive predictive value = 0.700, negative predictive value = 0.986, likelihood ratio = 16.42, number needed for screening utility = 0.639), and an AUC of 0.838 to detect MCI (sensitivity = 0.793, specificity = 0.671, positive predictive value = 0.657, negative predictive value = 0.803, likelihood ratio = 2.41, number needed for screening utility = 0.944). The subtests demonstrated moderate to high correlations with the gold-standard tests from their respective cognitive domains. The SCS total score and its memory scores all correlated positively with relative volumes of the whole hippocampus and almost all subregions, after controlling for age, sex, and education. Conclusion: The SCS has good diagnostic accuracy for detecting MCI and AD dementia and has the potential to facilitate large-scale screening in the general community.
Effect of additional dead space using end-tidal CO2 measurement on ventilating preterm infants: An experimental study
Authors: Mur Linda , Annon-Eberharter Natalee , Gombos Petra , Wald Martin 
Published: July 2023

BACKGROUND: Dead space is the part of the airway where no gas exchange takes place. Any increase in dead space volume has a proportional effect on the required tidal volume and thus on the risk of ventilation-induced lung injury. Inserts that increase dead space are therefore not used in small preterm infants. This includes end-tidal CO2 measurement. OBJECTIVE: The aim of this study was to investigate the effect of the end-tidal CO2 measurement adapter on ventilation. METHODS: In an experimental setup, an end-tidal CO2 measurement adapter, three different pneumotachographs (PNT-A, PNT-B, PNT-Neo), and a closed suction adapter were combined in varying set-ups. The time required for CO2 elimination by a CO2-flooded preterm infant test lung was measured. RESULTS: PNT-A prolonged CO2 elimination time by 0.9 s (+3.3%), Neo-PNT by 3.2 s (+11.6%) and PNT-B by 9.0 s (+32.7%). The end-tidal CO2 measurement adapter prolonged the elimination time by an additional second without the pneumotachograph (+3.6%) and in combination with PNT-A (+3.1%) and PNT-Neo (+3.1%). In conjunction with PNT-B, the end-tidal CO2 measurement adapter reduced the elimination time by 0.3 seconds (-1%). The use of a closed suction adaptor increased the CO2 elimination time by a further second with PNT-Neo (+3.1%) and by an additional two seconds with no flow sensor (+6.9%), with PNT-A (+6.4%) and with PNT-B (+5.5%). CONCLUSION: The flow sensor had the greatest influence on ventilatory effort, while end-tidal CO2 measurement had only a moderate effect. The increased ventilatory effort levied by the CO2 measurement was dependent on the flow sensor selected. The use of closed suctioning more negatively impacted ventilatory effort than did end-tidal CO2 measurement.
Penerapan Strategi Bisnis di Era Digital yang Dikelola Ibu Rumah Tangga Untuk Meningkatkan Pendapatan Keluarga (Studi Kasus Komunitas Womenpreneur Karawang)
Authors: Triadinda Dexi , Hidayaty Dwi Epty 
Published: July 2023

Peranan wanita khususnya ibu rumah tangga di era digital tidak lagi sebagai penonton di dunia bisnis, namun turut berperan dalam memberikan pendapatan bagi keluarga. Tujuan khusus penelitian ini adalah memperoleh gambaran strategi bisnis ibu rumah tangga di Kabupaten Karawang yang termasuk dalam komunitas womanpreneur di Era Digital. Batasan penelitian menggunakan teori strategi bersaing dari Michael Porter. Jenis penelitian ini adalah penelitian deskriptif kualitatif. Informan dalam peneltian terdiri dari tiga pengusaha wanita yang menekuni bisnisnya paling sedikit selama dua tahun kebelakang dan berdomisili di Kabupaten Karawang. Hasil dalam penelitian ini menunjukkan bahwa wanita memiliki peran penting dalam menungkatkan pendapatan keluarga melalui bisnis yang ditekuni. Disamping itu peran digitalisasi semakin memudahkan para pengusaha wanita dalam melakukan pemasaran dalam bisnis. The role of women, especially housewives in the digital era, is no longer as spectators in the business world, but also plays a role in providing income for the family. The specific objective of this study is to obtain an overview of the business strategies of housewives in Karawang Regency’s who are included in the womanpreneur community in the Digital Age. Limitation of research using competitive strategy theory from Michael Porter. This type of research is a qualitative descriptive research. The informants in the study consisted of three women entrepreneurs who had been in business for at least the past two years and were domiciled in Karawang Regency. The results in this study indicate that women have an important role in increasing family income through the business they are engaged in. Besides that, the role of digitization makes it easier for women entrepreneurs to do marketing in business.
Analisis Tingkat dan Sebaran Bencana Tanah Longsor di Kabupaten Bengkulu Tengah
Authors: Latif Muhammad , Andriani Andriani , Hakam Abdul 
Published: July 2023

Pertemuan tiga lempeng terbesar di dunia antara lempeng Indo-Australia, lempeng Eurasia, dan lempeng Pasifik menyebabkan Indonesia menjadi wilayah yang berpotensi akan terjadinya bencana longsor. Longsor merupakan kejadian pergerakan suatu massa tanah atau geologi yang melalui suatu bidang gelicir yang menuruni lereng. Kabupaten Bengkulu Tengah yang berada di Provinsi Bengkulu, merupakan daerah rawan bencana longsor, hal ini dapat dilihat berdasarkan kejadian-kejadian terdahulu, yang telah menyebabkan masyarakat mengalami kerugian harta benda dan korban jiwa. Analisis sebaran longsor ialah sebuah cara yang digunakan untuk mengetahui wilayah dengan tingkat potensi terjadinya longsor mulai dari tingkat rendah – sangat tinggi yang memungkinkan masyarakat dapat lebih waspada. Tujuan penelitian ini adalah untuk mengetahui sebaran kerawanan longsor dan menentukan faktor dominan yang mempengaruhi tingkat potensi longsor. Metode penelitian dilakukan dengan pemberian bobot dan skoring dengan acuan Puslittanak. Pembuatan peta longsor ini di peroleh dari hasil overlay data-data sekunder seperti DEM, sebaran tutupan lahan, sebaran curah hujan, sebaran geologi, dan sebaran jenis tanah yang menggunakan aplikasi ArcGIS 10.7. Hasil penelitian diperoleh tingkat sebaran longsor di Kabupaten Bengkulu Tengah didominasi oleh tingkat sebaran longsor yang sedang seluas 73455 Ha dengan persentase 60%. Daerah yang memiliki sebaran longsor sangat tinggi terdapat di empat kecamatan terdiri dari kecamatan Taba Penanjung, Meringgi Kelindang, Meringgi Sakti, dan Pematang Tiga seluas 8948 Ha dengan pesentase 7%. Sebaran peta curah hujan mempunyai nilai paling tinggi yang menjadi faktor paling dominan dalam proses terjadinya longsor.
HUBUNGAN DUKUNGAN KELUARGA TERHADAP KEPATUHAN MINUM OBAT PADA PASIEN TUBERKULOSIS PARU
Authors: Jumari  
Published: July 2023

Latar Belakang TBC (Tuberkulosis) yaitu suatu penyakit yang diakibatkan oleh infeksi Mycobacterium Tuberculosis. Secara global berdasarkan data World Health Organization (WHO) pada tahun 2016 terdapat 10,4 juta kasus insiden TBC (8,8 juta-12, juta) yang setara dengan 120 kasus per 100.000 penduduk. Lima negara dengan insiden kasus tertinggi yaitu India, Indonesia, China, Philipina, dan Pakistan. Profil Kesehatan Kementrian Kesehatan Republik Indonesia tahun 2016 mengatakan jumlah kasus TBC di Indonesia tertinggi di provinsi Jawa Barat sebanyak 52.328 kasus Berdasarkan data tersebut bahwa Daerah Khusus Ibukota Jakarta peringkat ketiga kasus TBC terbanyak di Indonesia yaitu sebesar 24.775 kasus. Dengan adanya dukungan keluarga/orang terdekat diharapkan sangat menunjang keberhasilan pengobatan seseorang dengan selalu mengingatkan penderita agar tetap rajin berobat.
Tujuan Penulisan : Untuk mengetahui hubungan dukungan keluarga terhadap kepatuhan minum obat pada pasien TB paru di Poli DOTS Rumah Sakit Umum Daerah Pademangan tahun 2020
Metode Penelitian :Desain penelitian ini adalah survei analitik dengan pendekatan Cross Sectional. Sampel berjumlah 71 pasien TB Paru diruang Poli TB DOTS. Tehnik pengumpulan sampel dengan menggunakan metode Purposive sampling. Tehnik pengumpulan data penelitian menggunakan data primer yang diambil langsung dari responden /informan denngan menggunakan kuesioner. Pengelolahan data menggunakan komputerisasi SPSS 25.0. Analisis yang digunakan adalah Univariat dan Bivariat (Chi- square) menggunakan batas kemaknaan Alpa = < 0,05
Hasil Penelitian : Hasil penelitian ini menunjukkan bahwa ada hubungan yang signifikan antara dukungan keluarga dengan kepatuhan minum obat pasien TB paru ( P = 0.000)
Kesimpulan : Dari ketiga variabel terdapat ada hubungan dukungan keluarga terhadap kepatuhan minum obat pada pasien TB Paru di Poli DOTS RSUD
Características epidemiológicas de la hernia diafragmática diagnosticada en la edad adulta.
Authors: Pérez Salcedo Fernando Rafael , Madrid Albertzy Francisco David , Ortíz Patrón María alejandra , Mahuad Suárez Jessica Marcela , Fuentes De Oro Nacira , Garcia Romero Alvaro Guillermo , Araújo Rodríguez Robinson Antolín , Pérez Villalba Víctor Daniel 
Published: July 2023

La hernia diafragmática se define como la protrusión de vísceras abdominales hacia el tórax a través de un defecto en el diafragma, asociado a un cambio en el gradiente de presiones entre estas dos cavidades. Esta es una patología rara en el adulto, que puede ser de origen congénito o adquirido, siendo este último la etiología más frecuente. Las causas principales de la misma son traumatismos cerrados o abiertos, ya sea por accidentes de tránsito, caídas a grandes alturas, heridas por arma de fuego o cortopunzantes. Es por esto por lo que suelen presentarse con mayor frecuencia en hombres jóvenes. Debido a la distribución de los órganos abdominales, se presentan con mayor frecuencia en el hemidiafragma izquierdo ya que no cuentan con la protección del hígado y diversos estudios muestran una disminución en el grosor del músculo en este lado. Debido a la localización, las vísceras más comúnmente evidenciadas son: estómago, intestino, bazo y páncreas. Las manifestaciones clínicas de esta patología son inespecíficas por lo que comúnmente se diagnostican de forma incidental al explorar otras patologías, sin embargo puede tener complicaciones fatales secundarias al estrangulamiento de las vísceras herniadas. Su abordaje en todos los casos es quirúrgico y depende de los factores individuales de cada paciente y de la decisión del cirujano la elección de un procedimiento abdominal o torácico. Debido a la mortalidad asociada a las complicaciones de esta patología surge la necesidad de conocer la epidemiología y establecer una sospecha clínica para lograr un diagnóstico y tratamiento temprano.