bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evolution of layering in a migmatite sample: Implications for the petrogenesis of multidomain monazite and zircon
Authors: Suarez Kaitlyn A. , Williams Michael L. , Grover Timothy W. , Jercinovic Michael J. , Pless Claire R. 
Published: August 2023

Abstract
The timing of partial melting in high-grade metamorphic rocks is critical for constraining tectonic histories and processes. However, uncertainties exist about the behavior of monazite and zircon during partial melting, especially about the timing of crystallization with respect to melting reactions. This study is focused on a single sample (16TG143) of finely layered, migmatitic gneiss from the Adirondack Highlands, New York, interpreted to have undergone extensive biotite dehydration melting (i.e., Bt + Pl + Als + Qz = Grt + Kfs + melt). The rock contains one distinct leucosome layer. The non-leucosome (gray gneiss) portion of the migmatite has millimeter-scale sublayers with distinct differences in modes and mineralogy. The layers are interpreted to reflect the differential preservation of reactants and products formed during the forward and reverse progress of the melting reaction. Monazite and zircon modes, and to some degree, texture, composition, and geochronology all vary from layer to layer. Both minerals have up to three domains: ca. 1150 Ma anhedral cores, ca. 1050 Ma monazite mantles/fir tree textured zircon, and ca. 1030 Ma rims. The heterogeneous layered gray gneiss provides robust constraints on the timing of melting (ca. 1050 Ottawan orogenesis), melt crystallization, and post-melting retrogression, in addition to information about earlier metamorphic events. Early-formed monazite and zircon grains were largely dissolved during progressive melting, except where preserved as relicts or inclusions. Monazite mantles and fir tree zircon grains precipitated upon cooling during progressive melt crystallization between temperatures of 800 and 750 °C. Rims are interpreted to have precipitated during subsolidus, solid-state retrogression after ca. 1050 Ma. Correlations between the gneissic layering, melting reactions, and the character of geochronometers emphasize the importance of characterizing the layer-forming and chronometer petrogenesis processes as a critical part of deconvoluting the history of migmatitic gneisses.
An analytical model for stream-stimulated hydraulic communication in vadose and saturated zones
Authors: Ma Chong , Jing Ruiping , Ma Ke , Wang Quanrong 
Published: August 2023

Abstract

A conceptual model was established to study the patterns of flow in vadose and saturated zones system induced by a prescribed boundary. Richards’ equation was adopted to describe groundwater flow in the vadose zone. Laplace transform and cosine Fourier transform were chosen to derive a semi-analytical solution of the governing equations. A finite-element numerical solution built with COMSOL software was used to test the semi-analytical solution. The buildups of the hydraulic head were investigated for different hydraulic parameters. Some noteworthy conclusions were obtained. The vadose zone parameters (constitutive exponent (κD) and specific yield (Sy)) have a significant effect on the buildups in the vadose zone and saturated zone. A larger κD value and smaller Sy value both lead to higher buildups in the vadose zone, while a larger κD value and a larger Sy value resulted in smaller buildups. As for the specific storage (Ss) of the saturated zone, the influence on buildup is more obvious in the saturated zone rather than in the vadose zone. The analysis further indicates that Media Anisotropy (Kz/Kx) value exhibits opposite influences on the hydraulic head in vadose and saturated zone. The present solution offers a valuable basis for further research of groundwater recharge and better design of MAR engineering.
Multiple, Extensive Cardiac and Pulmonary Hydatid Cysts Managed by a
Single-stage Surgical Removal: A Case Report
Authors: Egaimi Musab , Kim Byoung Kwon , Chang Ji Min 
Published: August 2023

Background:
Echinococcosis is a zoonotic infection that is characterised clinically by the development of hydatid cysts in different organs, mainly the liver and lungs. Cardiac involvement is rare but can lead to serious and fatal complications.

Case Report:
We report a rare challenging case of multiple, extensive cardiac and pulmonary Echinococcal cysts that were treated by successful single-stage surgical resection via median sternotomy without additional thoracic incisions.

Conclusion:
This article highlights the rare presentation of multiple, extensive cardiac and pulmonary Echinococcal cysts and how to overcome diagnostic challenges in the era of modern diagnostic imaging. Surgical removal remains the mainstay treatment, and a single-stage surgical approach is feasible in capable centres. Perioperative chemotherapy with Albendazole and the intraoperative use of scolicidal agents improved immediate surgical outcomes, although long-term effects could not be established in this case due to loss of follow-up.
Synthetic and Pharmacological Expedition of Pyrazolo[1,5-a]pyridine: A
Comprehensive Review
Authors: Agrawal Neetu , Bansal Dimple , Gautam Vertika 
Published: August 2023

Abstract:
Fused nitrogen-containing heterocyclic compounds have been identified to display a prominent
role in medicinal chemistry, biochemistry, and other streams of science. Countless derivatives of pyrazolo[
1,5-a] pyridine have been investigated by researchers for their distinct pharmacological characterization.
In this article, we have revealed and arranged the various routes of synthesis and therapeutic activities
such as dopamine binding affinity, kinase inhibitory activity, and PDE inhibitors of pyrazolo[1,5-
a]pyridine-containing compounds which have been explored till now. The remarkable outcomes obtained
via in vitro as well as in vivo profile screening of this moiety and its derivatives lead this scaffold to be
recognized to a greater extent and examined further for better results. This review will give medicinal
chemists a flying-bird eye catch view of pyrazolo[1,5-a] pyridine derivatives which will help them to
design and synthesize potential compounds bearing this moiety.
Ligand-Based and Structure-Based Virtual Screening of New Sodium
Glucose Cotransporter Type 2 Inhibitors
Authors: Estrada Ana Karen , Mendez-Alvarez Domingo , Juarez-Saldivar Alfredo , Lara-Ramirez Edgar E. , Martinez-Vazquez Ana Veronica , Villalobos-Rocha Juan Carlos , Palos Isidro , Ortiz-Perez Eyra , Rivera Gildardo 
Published: August 2023

Background:
Diabetes mellitus is a metabolic disease that causes multiple complications
and common comorbidities, which decreases the quality of life for people affected by the disease.
Sodium glucose cotransporter type 2 (SGLT2) participates in the reabsorption of 90% of glucose in
the kidneys; therefore, it is an attractive drug target for controlling blood glucose levels.

Objective:
The aim in this work was to obtain new potential SGLT2 inhibitors.

Methods:
A ligand-based virtual screening (LBVS) from the ZINC15, PubChem and ChemSpider
databases using the maximum common substructure (MCS) scaffold was performed.

Result:
A total of 341 compounds were obtained and analyzed by molecular docking on the active
site of SGLT2. Subsequently, 15 compounds were selected for molecular dynamics (MD) simulation
analysis. The compounds derived of spiroketal Sa1, Sa4, and Sa9 (≤ 3.5 Å) in complex with the receptor
SGLT2 showed good stability during 120 ns of MD.

Conclusion:
These compounds are proposed as potential SGLT2 inhibitors, blood glucose.
Analysis of Fluid Flows in Bounded Domain with Particular Shape of a Cavity using Lattice Boltzmann Method
Authors: Shetty Vikas Vasanth , Balashanker Kesana , Dharmaraj Arumuga Perumal , Patel Vedant Umang 
Published: August 2023

Background:
The present work numerically models the incompressible, continuous phase,
viscous flow of Newtonian fluid flow in a bounded domain of two-dimensional cavity that is driven by
walls and contains grooves in the shape of squares on the lower wall. With the help of the mesoscopic
lattice Boltzmann method (LBM) and D2Q9 square lattice model, simulation results are found stable
and reliable. The flow physics of the problem by varying Reynolds number, the height and quantity of
lower wall grooves, and other fluid flow characteristics within the bounded domain are studied in detail.
It is seen that the effects of the groove heights and wavelengths on the fluid flow are structured within
the bounded domain. The study is performed from low Re = 100 to high Re = 3200, with minimum two
and maximum four-wavelength grooves evaluated on the bottom surface, each having a height of low
0.25 and high 0.75. Additionally, a thorough discussion of complicated vortex dynamics is provided regarding
the input parameters and geometry.

Objective:
The current study aims to use mesoscopic LBM to analyze incompressible viscous fluid
flows on complex geometries other than rectangular shapes.

Methods:
Mesoscopic approach of kinetic theory-based Lattice Boltzmann method (LBM) is implemented
in the current work. The popular Single Relaxation Time Lattice Boltzmann method with D2Q9
square lattice model and second-order accurate boundary condition is adopted for the current study.

Results:
The numerical approach of LBM is used to simulate fluid flows in a 2D bounded domain with
grooved bottom surfaces. The influence of different factors, such as the height of bottom-wall surface
grooves, flow Reynolds number, and wavelength of these grooves on flow patterns, is then investigated.

Conclusion:
The numerical study of the bounded domain is considered, and the Reynolds number is
varied from 100 to 3200, with two and four-wavelength grooves evaluated on the bottom surface, each
having a height of 0.25 and 0.75. The impacts on the flow pattern both within and slightly above the
grooves of the computational findings for different Reynolds numbers, groove heights, and groove
wavelengths are evaluated. As the Reynolds number rises, the mixing phenomenon of fluid is shown to
flow more quickly in the wall-driven enclosures.
دیبلۆماسیه‌تی گشتی نوێی ئەمریکا: توێژینه‌وه‌یه‌كی تیۆری له‌سه‌ر ئامانج ومیکانیزمەکان
Authors: Karim Hana Muhammad , Faraj Anwar M. 
Published: August 2023

ئەمریکا ئەزموونێکی دوورو درێژی هەیە لەپراکتیزەکردنی دبلۆماسیەتی گشتی نوێ چونکە وڵاتێکی زلهێزە و هەژموونی بەسەر وڵات و ناوچەی زۆری دونیادا هەیە، ئەمەش پێویستی بە بەگەڕخستی دبلۆماسیەتی گشتییە، چی لە ڕووی زانیاری و چی لە ڕووی پەیوەندی و کردەییەوە. ئاماجی ئەم توێژینەوە گەڵاڵەکردنی دەروازەیەکی تیۆریە لەسەر ئامانج و میکانیزمەکانی بەکارهێنانی دبلۆماسی گشتی نوێی ئەمریکا کە وەکوو ئامرازێکی سیاسەتی دەرەوە لە پێناو بەدیهێنانی ئامانجەکانی پراکتیزەی دەکات. ئەم توێژینەوەیە لە ڕێگەی پێداچونەوە بە توێژینەوە سەرچاوەکانی پەیوەست بەبابەتەکەوە شرۆڤەی پاسا و تێزی توێژینەوەکە کراوە. لە ئەنجامدا توێژینەوەکە گشتووە بەوەی کە ئەمریکا بۆ بڵاوکردنەوەی بەهاکانی خۆی پشتی بە چەندین میکانیزمی کردەیی و زانیاری جیاواز بەستووە و گرنگترین میکانیزمە کردەییەکان بریتین لە: ئاڵوگۆڕی زانستی و پەروەردیی و کلتوری، یارمەتی و پاڵپشتیکردنی ڕۆژنامەنووسان و ڕێکخراوەکانی کۆمەڵگەی مەدەنی، هەماهەنگی سەربازی وئاسایش، بازرگانی و ئابوری بەمەبەستی کارکردن لەسەر وێنەی ئەرێنی خۆی لە کۆمەڵگەی نێودەوڵەتدا، لە هەمانکاتدا لە ڕێگەی میکانیزمی زانیاری و میدیاوە کار بۆ بڵاوکردنەوەی وێنەو گوتارو زانیاری و دروستکردنی مانا و پێکهێنانی ڕای گشتی دەکات، بە ئامانجی گۆڕینی تێڕوانینی جیهان، بەجۆرێک کە کاریگەرببن بە بەهاکانی ئەمریکا، لەم چوارچێوەیەشدا بە ستراتیژیەکی فراوان بە پشت بەستن بە کەناڵەکانی ڕاگەیاندن وچاپکراوەکان و پیشەسازی کلتوری و تۆڕەکۆمەڵایەتیەکان کاردەکات
Use of Biological Feedback as a Health Behavior Change Technique in Adults: Scoping Review
Authors: Richardson Kelli M , Jospe Michelle R , Saleh Ahlam A , Clarke Thanatcha Nadia , Bedoya Arianna R , Behrens Nick , Marano Kari , Cigan Lacey , Liao Yue , Scott Eric R , Guo Jessica S , Aguinaga April , Schembre Susan M 
Published: August 2023

Background
Recent advancements in personal biosensing technology support the shift from standardized to personalized health interventions, whereby biological data are used to motivate health behavior change. However, the implementation of interventions using biological feedback as a behavior change technique has not been comprehensively explored.

Objective
The purpose of this review was to (1) map the domains of research where biological feedback has been used as a behavior change technique and (2) describe how it is implemented in behavior change interventions for adults.

Methods
A comprehensive systematic search strategy was used to query 5 electronic databases (Ovid MEDLINE, Elsevier Embase, Cochrane Central Register of Controlled Trials, EBSCOhost PsycINFO, and ProQuest Dissertations & Theses Global) in June 2021. Eligible studies were primary analyses of randomized controlled trials (RCTs) in adults that incorporated biological feedback as a behavior change technique. DistillerSR was used to manage the literature search and review.

Results
After removing 49,500 duplicates, 50,287 articles were screened and 767 articles were included. The earliest RCT was published in 1972 with a notable increase in publications after 2000. Biological feedback was most used in RCTs aimed at preventing or managing diabetes (n=233, 30.4%), cardiovascular disease (n=175, 22.8%), and obesity (n=115, 15%). Feedback was often given on multiple biomarkers and targeted multiple health behaviors. The most common biomarkers used were anthropometric measures (n=297, 38.7%), blood pressure (n=238, 31%), and glucose (n=227, 29.6%). The most targeted behaviors were diet (n=472, 61.5%), physical activity (n=417, 54.4%), and smoking reduction (n=154, 20.1%). The frequency and type of communication by which biological feedback was provided varied by the method of biomarker measurement. Of the 493 (64.3%) studies where participants self-measured their biomarker, 476 (96.6%) received feedback multiple times over the intervention and 468 (94.9%) received feedback through a biosensing device.

Conclusions
Biological feedback is increasingly being used to motivate behavior change, particularly where relevant biomarkers can be readily assessed. Yet, the methods by which biological feedback is operationalized in intervention research varied, and its effectiveness remains unclear. This scoping review serves as the foundation for developing a guiding framework for effectively implementing biological feedback as a behavior change technique.

Trial Registration
Open Science Framework Registries; https://doi.org/10.17605/OSF.IO/YP5WAd

International Registered Report Identifier (IRRID)
RR2-10.2196/32579
The Impact of Web-Based Continuing Medical Education Using Patient Simulation on Real-World Treatment Selection in Type 2 Diabetes: Retrospective Case-Control Analysis
Authors: Lucero Katie Stringer , Larkin Amy , Zakharkin Stanislav , Wysham Carol , Anderson John 
Published: August 2023

Background
Despite guidelines recommending the use of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) in certain patients with type 2 diabetes (T2D), they are not being prescribed for many of these patients. Web-based continuing medical education (CME) patient simulations have been used to identify clinicians’ practice gaps and improve clinical decision-making as measured within a simulation, but the impact of this format on real-world treatment has not been researched.

Objective
This study aimed to evaluate the effect of a simulation-based CME intervention on real-world use of GLP-1 RAs by endocrinologists and primary care physicians.

Methods
Two evaluation phases of the CME simulation were conducted: phase I, the CME simulation phase, was a paired, pre-post study of 435 physician learners in the United States; and phase II, the real-world phase, was a retrospective, matched case-control study of 157 of the 435 physicians who had claims data available for the study period.

Results
Phase I CME results showed a 29 percentage point increase in correct decisions from pre- to postfeedback (178/435, 40.9% to 304/435, 69.9%; P<.001) in selecting treatment that addresses both glycemic control and cardiovascular event protection. Phase II results showed that 39 of 157 (24.8%) physicians in the intervention group increased use of GLP-1 RAs, compared to 20 of 157 (12.7%) in the comparison group. Being in the intervention group predicted GLP-1 RA use after education (odds ratio 4.49; 95% CI 1.45-13.97; P=.001).

Conclusions
A web-based CME simulation focused on secondary prevention of cardiovascular events in a patient with T2D was associated with increased use of evidence-based treatment selection in the real world.
La diversidad de la estructura económica local y su relación con la demanda ocupacional y los índices de pobreza en las zonas metropolitanas de México
Authors: Segura Mojica Francisco Javier 
Published: August 2023

<p>Esta investigación explora la forma en que la diversidad de la estrucura económica en las zonas metropolitanas se relaciona con la demanda ocupacional y con los índices de pobreza moderada y extrema. Se analizaron datos de una muestra de 29 zonas metropolitanas de México. Al análisis se incorporaron las variables Índice de Diversidad de Simpson (IDS), Tasa de Informalidad, Variación del PIB Estatal y Años de Escolaridad como predictores de empleo y pobreza. Como herramientas de análisis se utilizó estadística descriptiva e inferencial y se formularon modelos de regresión lineal y PLS. Como resultado relevante se encontró que existe una correlación significativa de signo positivo entre el IDS y el número de Asegurados Permanentes; así como correlaciones significativas de signo negativo entre el IDS y el porcentaje de población en situación de pobreza moderada y pobreza extrema.</p>
Monitoring Sistem Pembangkit Listrik Tenaga Angin Berbasis Internet of Things
Authors: Wicaksono Dwi Haryo , Djuniadi Djuniadi , Apriaskar Esa 
Published: August 2023

Terjadinya perubahan iklim yang ekstrem di Indonesia saat ini berdampak pada kenaikan suhu udara secara mendadak, hal ini dapat disebabkan karena tingkat polusi udara yang tinggi. Tingkat polusi udara yang tinggi disebabkan oleh penggunaan energi fosil secara terus menerus sebagai sumber energi utama, mulai dari pembangkit listrik bertenaga fosil hingga banyaknya kendaraan konvensional yang masih digunakan. Pembangkit listrik tenaga angin (PLTB) mampu menjadi solusi permasalahan penggunaan energi fosil. Angin dapat memutar generator turbin untuk menghasilkan energi listrik. Kecepatan angin yang melewati turbin sangat berdampak terhadap besarnya energi yang dihasilkan. Kecepatan angin yang tidak stabil akan mempengaruhi proses pembacaan data output karena proses pengukuran output turbin angin masih menggunakan pengukuran manual (analog). Sehingga dalam proses pembacaan data output menjadi terganggu dan hasil yang didapat belum akurat. Tujuan dari penelitian ini adalah melakukan analisa monitoring terhadap energi yang dihasilkan dari suatu pembangkit listrik tenaga angin berbasis Internet of Things (IoT) menggunakan prototype yang telah dibuat. Prototype yang telah dibuat menggunakan Sensor INA 219 sebagai pengukur energi dari turbin dan NodeMCU sebagai pengontrol serta pengirim data yang dihasilkan sensor ke software Blynk. Dari hasil pengujian alat monitoring PLTB, diperoleh nilai tegangan yang dihasilkan turbin cukup stabil yaitu antara 0.86 V hingga 0.87 V dengan daya terbesar yang dihasilkan selama pengujian adalah 6370,93 mW. Perbedaan jarak turbin dengan kipas angin memberikan pengaruh yang signifikan terhadap besarnya nilai arus yang dihasilkan. Nilai arus yang dihasilkan selama pengujian yaitu 0,1 mA hingga 7,3 mA. Perubahan nilai tegangan tidak mempengaruhi kondisi LED.
PENGARUH BERBAGAI KONSENTRASI ROOTONE-F DAN KOMPOSISI MEDIA TANAM BERBEDA TERHADAP PERTUMBUHAN STEK JAMBU BIJI KRISTAL (Psidium guava L.)
Authors: Ulandari Sulistika , Lasmini Sri Anjar , Salingkat Chitra Anggriani 
Published: August 2023

Penelitian ini bertujuan untuk mengetahui pengaruh konsentrasi rootone-F dan komposisi media tanam berbeda terhadap pertumbuhan stek jambu biji kristal. Waktu penelitian dimulai dari Juni sampai Agustus 2021. Penelitian ini menggunakan metode Rancangan Acak Kelompok (RAK) pola faktorial, faktor pertama yaitu konsentrasi rootone-F yang terdiri dari 4 taraf yaitu R1 (500 mg/l air), R2 (1000 mg/l air), R3 (1500 mg/l air) dan R4 (2000 mg/l air). Faktor kedua yaitu perlakuan media tanam yang terdiri dari 2 taraf yaitu M1 (Tanah + Pupuk Kandang Kambing 3:1) dan M2 (Tanah + Pupuk Kandang Kambing + Sekam Padi 3:1:1) sehingga diperoleh 8 kombinasi perlakuan, diulang sebanyak 3 kali sehingga terdapat 24 unit percobaan. Berdasarkan data yang telah diperoleh dalam penelitian ini maka dapat disimpulkan bahwa pemberian konsentrasi rootone-F 500 mg/l air memberikan pengaruh pertumbuhan tanaman lebih baik dibandingkan dengan konsentrasi lainnya dan penggunaan media tanam yang baik untuk digunakan yaitu campuran tanah, pupuk kandang kambing dan sekam padi dengan perbandingan 3:1:1.
Tratamiento del tabaquismo guiado por marcadores genéticos
Authors: Hincapié López Gloria , Isaza Mejía Carlos Alberto , Santafé Sánchez Robert , Beltrán Angarita Leonardo 
Published: August 2023

Introducción: Entre las adicciones por drogas, el tabaquismo ocupa el primer lugar como causa de morbimortalidad y es factor de riesgo para seis de las ocho principales causas de muerte en el mundo. La nicotina es el principal componente adictivo del tabaco. En la terapia de reemplazo con nicotina (TRN), la vareniclina y el bupropion son los medicamentos aproba- dos para tratamiento del tabaquismo, pero los resultados de las clínicas de dejación del tabaquismo sugieren que aún se desconoce muchas variables influyentes en la respuesta al tratamiento.
Objetivo: Determinar la adherencia, la tolerabilidad y la efectividad de un programa de dejación de tabaquismo basado en nicotina o bupropion, en pacientes con dependencia al tabaco, seleccionados según los genotipos de las enzimas que metabolizan los dos fármacos.
Hallazgos clínicos: Se incluyeron en esta serie 21 fumadores, 67% hom- bres, con edad promedio de 46,2±11,7 años. Su tabaquismo comenzó a los 17,8±6 años y llevaban fumando 28±13 años. Al inicio del estudio fumaban 17±12 cigarrillos por día (CPD), habían hecho 3,7±2 intentos de dejar de fumar y el puntaje NDSS (escala breve de evaluación de dependencia de la nicotina, por sus siglas en inglés) fue de 22±5 (punto de corte para depen- dencia a nicotina: 11 o más puntos).
Tratamiento: Los pacientes tenían libre acceso telefónico al médico tra- tante y, cada semana, una consulta consistente en consejería y control del tratamiento farmacológico prescrito según los genotipos CYP2A6 (que co- difica la enzima que metaboliza la nicotina) y CYP2B6 (que codifica la enzima que metaboliza el bupropion). Se empleó nicotina en parches transdérmicos de 14 mg el primer mes y luego de 7 mg el segundo mes, complementados con chicles para manejo del síndrome de abstinencia y bupropion en forma de liberación regulada por 300 mg, 1-2 veces al día.
Resultados: Después de 8 semanas de tratamiento y 4 de observación, 15 sujetos (71,4%) respondieron en forma parcial/total. El consumo de CPD bajó de 17±12 al inicio del estudio, a 2,2±3,5 al final del estudio, que co- rresponde a una reducción de 195 cigarrillos/día. Siete de ocho pacientes tratados con bupropion (87,5%) y siete de trece tratados con nicotina (54%) tuvieron respuesta parcial/total. Solo un paciente formulado con nicotina suspendió el medicamento por intolerancia gastrointestinal (náusea y vó- mito). La tasa de recaídas, evaluada un mes después del tratamiento farma- cológico, fue de cero. Se encontró buena correlación genotipo-fenotipo en los individuos tratados con bupropion, pero no en los tratados con nicotina.
Relevancia clínica: La inclusión de marcadores farmacogenéticos para la elección de nicotina o bupropion en un programa de dejación de tabaquis- mo puede mejorar la adherencia, la tolerabilidad al fármaco y la efectividad del tratamiento.