bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dampak rencana operasi Pangkalan Udara Gatot Subroto Way Kanan menjadi bandar udara komersial ditinjau dari aspek spasial
Authors: Haridan Zulman , Sulistiyorini Rahayu , Affandi Muhammad Irfan 
Published: August 2023

<p>Bandar udara memiliki peran sebagai pintu gerbang kegiatan perekonomian dalam upaya pemerataan pembangunan, pertumbuhan dan stabilitas ekonomi, serta keselarasan pembangunan nasional dan pembangunan daerah. Salah satu isu penentuan tujuan perencanaan Kabupaten Way Kanan dalam RTRW Provinsi Lampung adalah peluang pendayagunaan Pangkalan Udara TNI Angkatan Darat Gatot Subroto sebagai bandara komersial untuk mengakomodasi kebutuhan mobilitas sipil yang cepat, nyaman, dan ekonomis. Namun, pemanfaatan peluang tersebut memiliki limitasi berupa keterbatasan kapasitas untuk penggunaan lahan sebagai bandara komersial. Penelitian ini bertujuan untuk mengidentifikasi strategi pengembangan kawasan Bandar Udara Gatot Subroto dalam mendukung pengembangan wilayah dan pertumbuhan ekonomi wilayah. Metode penelitian yang digunakan, yaitu analisis deskriptif kuantitatif dengan alat analisis Satuan Kemampuan Lahan (SKL) untuk mengetahui daya dukung agar tindak perencanaan berada dalam kapasitas optimal keberlanjutan ekosistem Analisis SWOT serta QSPM juga digunakan untuk mengidentifikasi strategi pengembangan Kawasan Bandara Gatot Subroto. Hasil analisis SKL menunjukkan tiga klasifikasi kemampuan lahan di kawasan tersebut dengan persentasi terbesar, yaitu 86,28% kemampuan lahan baik, 8,54% dengan kemampuan cukup baik, dan 5,18% dengan kemampuan sangat baik. Strategi pengembangan Bandara Gatot Subroto yang direkomendasikan adalah penguatan aspek kelembagaan untuk menunjang fasilitas layanan pendukung yang dapat memudahkan pengguna bandara dan melakukan pengembangan potensi pariwisata Kabupaten Way Kanan sebagai daya tarik untuk wisatawan.</p>
Total Knee Arthroplasty Using Computer-Assisted Navigation in a Patient with Nail-Patella Syndrome
Authors: Courington Reese , Kerr Matthew , Adigweme Obinna 
Published: August 2023

Case:
Nail-patella syndrome (NPS) is a genetic disorder causing anatomical abnormalities about the knee, including significant patellar hypoplasia. We present a case of a patient with NPS and severe knee osteoarthritis undergoing computer-assisted total knee arthroplasty (TKA). Several intraoperative anatomical challenges were appreciated. Postoperatively, the patient developed arthrofibrosis requiring manipulation; however, his final outcome was favorable.

Conclusion:
Computer assistance may improve precision in patients with NPS undergoing TKA, but surgeons must be aware of the associated anatomic abnormalities and potentially increased risk of arthrofibrosis. Patellar resurfacing is often not feasible because of lack of bone stock.
Longitudinal Assessment of Modern Spine Surgery Training
Authors: Daniels Alan H. , Alsoof Daniel , McDonald Christopher L. , Zhang Andrew S. , Diebo Bassel G. , Eberson Craig P. , Kuris Eren O. , Lavelle William , Ames Christopher P. , Shaffrey Christopher I. , Hart Robert A. 
Published: August 2023

Background:
Spine surgeons complete training through residency in orthopaedic surgery (ORTH) or neurosurgery (NSGY). A survey was conducted in 2013 to evaluate spine surgery training. Over the past decade, advances in surgical techniques and the changing dynamics in fellowship training may have affected training and program director (PD) perceptions may have shifted.

Methods:
This study is a cross-sectional survey distributed to all PDs of ORTH and NSGY residencies and spine fellowships in the United States. Participants were queried regarding characteristics of their program, ideal characteristics of residency training, and opinions regarding the current training environment. χ2 tests were used to compare answers over the years.

Results:
In total, 241 PDs completed the survey. From 2013 to 2023, NSGY increased the proportion of residents with >300 spine cases (86%-100%) while ORTH remained with >90% of residents with < 225 cases (p < 0.05). A greater number of NSGY PDs encouraged spine fellowship even for community spine surgery practice (0% in 2013 vs. 14% in 2023, p < 0.05), which continued to be significantly different from ORTH PDs (∼88% agreed, p > 0.05). 100% of NSGY PDs remained confident in their residents performing spine surgery, whereas ORTH confidence significantly decreased from 43% in 2013 to 25% in 2023 (p < 0.05). For spinal deformity, orthopaedic PDs (92%), NSGY PDs (96%), and fellowship directors (95%), all agreed that a spine fellowship should be pursued (p = 0.99). In both 2013 and 2023, approximately 44% were satisfied with the spine training model in the United States. In 2013, 24% of all PDs believed we should have a dedicated spine residency, which increased to 39% in 2023 (fellowship: 57%, ORTH: 38%, NSGY: 21%) (p < 0.05).

Conclusion:
Spine surgery training continues to evolve, yet ORTH and neurological surgery training remains significantly different in case volumes and educational strengths. In both 2013 and 2023, less than 50% of PDs were satisfied with the current spine surgery training model, and a growing minority believe that spine surgery should have its own residency training pathway.

Level of Evidence:
IV.
Clinician and patient views on janus kinase inhibitors in the treatment of inflammatory arthritis: a mixed methods study
Authors: de Souza Savia , Williams Ruth , Nikiphorou Elena 
Published: August 2023

Abstract
Background: Janus kinase inhibitors (JAKi) are new targeted synthetic disease-modifying antirheumatic drugs (DMARDs) licenced in the UK to treat rheumatoid and psoriatic arthritides. Unlike currently often prescribed biological DMARDs, they target a different part of the inflammatory pathway and are taken orally. The aim of this study was to explore what UK-based rheumatology clinicians and inflammatory arthritis (IA) patients think about the awareness, prescription and use of JAKi; how they compare with biologics; and how the COVID-19 pandemic has affected how JAKi are viewed and prescribed.
Methods: Rheumatology clinicians and IA patients completed online surveys and participated in interviews/focus groups between September 2021 and January 2022. Survey data were analysed descriptively and interview/focus group data underwent an inductive thematic analysis.
Results: 66.6% of patients had at least some awareness of JAKi, 73.0% from their rheumatology team. Problems getting earlier access to these drugs were raised by some patients, with many being prescribed JAKi after multiple other therapies had failed. 91.5% of clinicians prescribed JAKi in keeping with their local guidelines, with 72.3% prescribing them frequently as a monotherapy. Some clinicians had lingering safety concerns over JAKi use. Despite experiencing side effects and knowing of possible long-term risks, patients felt overall the benefits of JAKi outweighed the risks. 39.3% of patients were ‘very satisfied’ on JAKi, compared with 25.0% on biologics. Patients on JAKi appreciated their short half-life when it comes to infections, and their convenience as an oral therapy. When JAKi were discontinued in patients, it was predominantly due to inefficacy and non-cardiovascular adverse events. The COVID-19 pandemic resulted in increased prescription of JAKi as an alternative to injections and infusions, primarily to avoid potentially exposing patients to the coronavirus. Some patients believed their JAKi may confer some protection against developing severe COVID-19.
Conclusion: JAKi are an effective treatment option for IA and are liked by patients. The COVID-19 pandemic appears to have impacted their prescription favourably. However, clinicians have safety concerns over JAKi use. Any decision to go on a JAKi should be informed and take into account individual patient risk factors, circumstances and preferences.
Advancing Quality and Environmental Responsibility: A Stability-Indicating LC Method Development for Lenvatinib through QbD and Green Chemistry
Authors: Patel Mital 
Published: August 2023

Abstract
A Quality by Design (QbD) technique that was systematic and analytical was utilized to create and confirm a novel and sensitive stability-indicating method of Lenvatinib via the HPLC method. To comply with ICH Q1(A) guidelines, a study was conducted to determine the degradation behavior of Lenvatinib under various environmental conditions. The QbD approach involved screening and optimization, which included using Placket Burman to assess primary parameters, and Response Surface Design (RSD) to optimize critical factors. The degradation was examined under different degradation conditions, including acidic, basic, oxidative, neutral, thermal, and photolytic, and was separated using a Shimadzu® C18 column (250 mm x 4.6 mm, particle size 5 µ). The mobile phase consisted of a concentration of Acetonitrile: 10 mM ammonium acetate having pH 3.5 (39:61, v/v) at a flow rate of 0.8 mL/min, 20 min run time, and 245 nm wavelength. The drug was particularly sensitive towards acidic and basic hydrolysis stress conditions, which generated a total of five degradant products that were successfully identified with the optimized LC-MS compatible analytical method. The optimized method was found to be sensitive, reproducible, specific, and robust, with a linearity range of 10 to 60 mg/mL and a correlation coefficient (R2 = 0.9993). The greenness score of the analytical method was calculated, and it was observed that the developed method was environmentally friendly.
IoT-based Enhanced Decision-making and data mining for digital transformation of Tobacco Companies
Authors: Lin Yu 
Published: August 2023

Abstract
In recent years, the Internet of Things (IoT) has transformed various sectors, including the tobacco industry, by offering digital transformation opportunities. There is enormous potential for improving decision-making and commercial performance in the tobacco sector via integrating IoT-enabled digital transformation and data mining approaches. Tobacco businesses could achieve a competitive advantage in the market by using the features of IoT devices to improve internal processes, stimulate innovation, and provide a more satisfying consumer experience. However, this study aims to increase tobacco firms' market share, performance, core competitiveness, and digital transformation used to boost corporate performance. Data mining will be used to assess the cigarette industry's financial success after the digital revolution. The IoT's layered design helps cigarette companies increase production. Expanding manufacturing capacity in enterprises' production chains may boost productivity and yield at each IoT level. This meta-analysis examines the correlations between tobacco businesses' digital transformation and commercial success, focusing on four major dimensions: digital technology, digital strategy, digital capacity, and digital culture. This framework's functional links and contextual components are explored using IoT. The cigarette industry's success is tied to digital technology's four dimensions, with digital culture having the largest influence. The research uses an upgraded version of the Iterative Dichotomiser 3 (ID3) decision tree approach to assessing cigarette businesses' success after digital transformation. This work added attribute gain correction and information entropy calculations to the ID3 decision tree technique. Through IoT, the ID3 decision tree method's performance has been optimized. This study has shown robust data mining, great efficiency in the IoT, and high accuracy in categorizing varied data sets. Tobacco companies may increase their performance by increasing total competition capacity.
Racial Differences in Triage Assessment at Rural vs Urban Maine Emergency Departments
Authors: Puissant Madeleine , Agarwal Isha , Scharnetzki Elizabeth , Cutler Anya , Gunnell Hadley , Strout Tania 
Published: August 2023

Abstract
Data continues to accumulate demonstrating that those belonging to racialized groups face implicit bias in the emergency care delivery system across many indices, including triage assessment. The Emergency Severity Index (ESI) was developed and widely implemented across the US to improve the objectivity of triage assessment and prioritization of care delivery; however, research continues to support the presence of subjective bias in triage assessment. We sought to assess the relationship between perceived race and/or need for translator and assigned ESI score and whether this was impacted by hospital geography. We performed retrospective EMR-based review of patients presenting to urban and rural emergency departments of a health system in Maine with one of the top ten most common chief complaints (CC) across a 5-year period, excluding psychiatric CCs. We used multivariable regression to analyze the relationships between perceived race, need for translator, and gender with ESI score, wait time, and hallway bed assignments. We found that patients perceived as non-white were more likely to receive lower acuity ESI scores and have longer wait times as compared to patients perceived as white. Patients perceived as female were more likely to receive lower acuity scores and wait longer to be seen than patients perceived as male. The need for an interpreter was associated with increased wait times but not significantly associated with ESI score. After stratification by hospital geography, evidence of subjective bias was limited to urban emergency departments and was not evident in rural emergency departments. Further investigation of subjective bias in emergency departments in Maine, particularly in urban settings, is warranted.
Spectral-domain optical coherence tomography morphological characteristics in patients with cone dystrophy
Authors: Leung Loh-Shan , Khojasteh Hassan , bazvand fatemeh , Haidari Mostafa , Mahmoudi Alireza , Mohammadi S. Saeed , Riazi-Esfahani Hamid , Mirghorbani Masoud , Salmasi Arefeh Sheikholeslami , Azarkish Afsaneh , Regenold Jonathan , Akhavanrezayat Amir , Karaca Irmak , Park Sung Who , Uludag Gunay , Or Chris , Ghoraba Hashem , Dong Quan 
Published: August 2023

Abstract
Purpose: To describe spectral-domain optical coherence tomography (SD-OCT) morphological characteristics in patients with cone dystrophy.
Methods: Forty-two patients (84 eyes) with the diagnosis of cone dystrophy based on clinical findings and electroretinogram reports (severely reduced or non-recordable cone response with preserved rod function) were included in our study. SD-OCT was performed and images were evaluated regarding the integrity and pattern of hyper-reflective outer retinal bands and other findings. The relationship between these findings, age, central subfoveal thickness (CST), and best-corrected visual acuity (BCVA) was assessed.
Results: 82 of 84 eyes (98 %) showed outer retinal layer abnormalities on SD-OCT. Five different morphological categories were identified on SD-OCT, including outer retinal atrophy (24.4%), undifferentiated outer retinal layers (22.0%), ellipsoid zone (EZ) disruption (19.5%), outer foveal defect (17.1%), and prominent outer retinal layers (17.1%). Also, five isolated OCT findings were detected, including foveal hypoplasia (14.6%), trans-retinal hyperreflective dots (THD) (29.3%), outer plexiform layer (OPL) schisis (11.3%), pseudodrusen (9.8%), and EZ bowing (13.4%). Age and CST were significantly different across the morphological categories (p<0.001). Eyes with prominent outer retinal layers and outer retinal atrophy had the best and worst visual acuity, respectively; however, the difference was not significant (p=0.16).
Conclusion: SD-OCT imaging shows variety of morphologic findings in cone dystrophy, which may be utilized in the assessment of these patients and may serve as predictive biomarkers for VA.
Obesity and Abdominal hernia risk: Mendelian randomization study
Authors: Zhang Xiao-Li , Fang Yuan , Zhang Xin-Feng , Wang Yu-Han , Liu Xin-Yu , Tian Yan , Luo Hua-You 
Published: August 2023

Abstract
With the change in people's dietary habits and lifestyles, the incidence of obesity is increasing. Obesity has been recognized as a risk factor for a number of diseases, including abdominal wall hernias. The aim of our study was to investigate the causal relationship between obesity and abdominal wall hernia development through a two-sample Mendelian randomization study and to quantify the risk of abdominal wall hernia (AH) development with respect to obesity-related assessment indicators body mass index (BMI), waist circumference (WC) and body fat percentage (BFP). Our results found a 56% increase in the risk of AH for each SD increase in genetically determined BMI, a 55% increase in the risk of AH for each SD increase in genetically determined WC, and a 60% increase in the risk of AH for each SD increase in genetically determined BFP. It is still reasonable to recommend obese individuals to lose weight and maintain a healthy weight for the purpose of preventing the development of abdominal wall hernias.
The contribution of risk perception and social norms to reported preventive behaviour against selected vector-borne diseases in Guyana
Authors: Lopes-Rafegas Iris , Cox Horace , Mora Toni , Sicuri Elisa 
Published: August 2023

Abstract
Preventing vector-borne diseases (VBDs) mainly relies on effective vector control tools and strategies, which in turn depend on population acceptance and adherence. Inspired by the abundant recent literature on SARS-COV-2, we investigate the relationship between risk perception and preventive behaviour for selected VBDs and the extent to which risk perception is determined by social norms. We use cross-sectional data collected from 497 individuals in four regions of Guyana in 2017. We use a conditional mixed process estimator with multilevel coefficients, estimated through a Generalized Linear Model (GLM) framework, applying a simultaneous equation structure. We find robust results on malaria: risk perception was significantly influenced by the risk perception of the reference group across different definitions of the reference group, hinting at the existence of social norms. Risk perception significantly increased the likelihood of passive behaviour by 4.48%. Less clear-cut results were found for dengue. This study applies quantitative social science methods to public health issues in the context of VBDs. Our findings point to the relevance of tailoring communications on health risks for VBDs to groups defined at the intersection of socio-economic and demographic characteristics. Such tailored strategies are expected to align risk perception among reference groups and boost preventive behaviour.
Genetic Testing of Fetal Loss of Heterozygosity Using Single Nucleotide Polymorphism Array and Whole Exome Sequencing
Authors: Xue Huili , Yu Aili , Zhang Lin , Chen Lingji , Guo Qun , Lin Min , lin Na , Chen Xuemei , Xu Liangpu , Huang Hailong 
Published: August 2023

Abstract
Background
To explore the clinical significance of fetal loss of heterozygosity (LOH), identified by single-nucleotide polymorphism array (SNP array).
Methods
We retrospectively reviewed data form pregnant women who underwent invasivediagnostic procedure at prenatal diagnosis centers in Southeastern China from December 2016 to December 2021. SNP array was performed by the Affymetrix CytoScan 750K array platform. Fetuses with LOH (10 Mb as the threshold or over 5 Mb involving imprinted chromosomes) were further identified by parental verification, MS-MLPA, and/or trio whole exome sequencing (trio-WES), and the genetic results, fetal clinical manifestations, and perinatal outcome were comprehensively analyzed.
Results
Of 11 062 fetuses, 106 (0.96%) with LOH exhibiting a neutral copy number were detected; in 88 (83.0%) of these, LOH occurred in a single chromosome, while 18 (17.0%) fetuses had multiple LOHs on different chromosomes. A total of 66 fetuses had ultrasound anomalies (UAs); the most frequent UA was fetal growth restriction (18/66 (27.3%)). Further genetic analysis was performed in 42 cases (21 cases by parental SNP array verification and 21 cases by trio-WES), in which, we found clinically relevant uniparental disomy in 12 cases, pathogenic variants in five cases, likely pathogenic variants in four cases, variant of unknown significance in six cases, and identity by descent in eight cases. Significantly, the rate of adverse pregnancy outcomes in fetuses with LOH and UAs (24/66 (36.4%)) was higher than in those without UAs (6/40 (15.0%)) (p< 0.05).
Conclusions
Fetuses with LOH is not uncommon. Various molecular genetic testing techniques, such as parental SNP array verification, trio-WES, MS-MLPA, regular and systematic ultrasonic monitoring, and the placental study when necessary, should be performed to accurately assess the prognosis of fetal LOH and guide the affected pregnancy management.
On enhancing the noise-reduction performance of the acoustic lined duct utilizing the phase-modulating metasurface
Authors: Ou Yang , Zhao Yonghui 
Published: August 2023

Abstract
This work proposes a noise-reduction structure that integrate phase-modulating metasurface (PMM) with acoustic liners (ALs) to enhance the absorption performance of a duct with relatively small length-diameter ratio. The PMM manipulate the wavefront by introducing different transmission phase shifts, so that the spinning wave within the duct is generated. Compared with the plane wave, the generated spinning wave has a lower group velocity, which results in a greater traveling distance over the ALs in the duct. The optimization design is performed to determine the final structural parameters of the PMM, which is based on the predictions of the amplitude and phase shift of the acoustic wave at the outlet of the PMM using the theory of metascreen-based acoustic passive phased array. With the manipulation of the PMM, the incident plane wave is modulated into a spinning wave, and then enters into the ALD, whose structural parameters are optimized by maximizing the transmission loss using the mode-matching technique. Finally, the noise-reduction performance of this combined structure is evaluated by numerical simulations. The results demonstrate that, compared with the traditional ALD, the proposed structure exhibits a 83.8% increase in transmission loss, and hence the noise-reduction performance is significantly improved.