bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Widening Road: Constructions of Gay Japanese Men on YouTube
Authors: Furukawa Gavin 
Published: April 2023

AbstractThis chapter examines the discourses found in Japanese gay vlog entries to see how such streaming contents are used as sites of contact between gays and straights in Japan. Early internet sites created safe public spaces for sexual minority members to meet and socialize where straights previously seldom had access or were expressly unwelcome. Using a collection of coming out and Q and A videos, the chapter will also explore the use of vlogging discourse for social change in Japan. More recently, sites like YouTube have created new contact spaces where straights are welcomed and can interact with gay content creators more directly. This chapter analyzes the ways in which Japanese gay men construct themselves as well as other gay and straight people around them in these videos. Utilizing membership categorization and indexicality the analysis will show how notions of family and gayness along with associated bound predicates are used to discursively resist heteronormativity. The discourse also shows how these videos focus on the purposes of informing and educating over phatic communication. The analysis will also demonstrate how the concept of internationalization has become semiotically relevant to the gay Japanese male category, constructing an image of masculine interculturality, contrasted against overly feminine mass-mediated stereotypes. Possibilities for further change and social justice in Japan through such sites of contact will also be discussed.
Boys’ Love, Transmedia Storytelling, and LGBT Awareness in Contemporary Japan
Authors: Nozawa Emiko 
Published: April 2023

AbstractWith the recent “LGBT Boom,” the media coverage of individuals, activism, the news, and films and dramas related to LGBT people is increasing in Japan. There are several hit movies and TV dramas about so-called LGBT people, where male-male romantic relationships are often depicted, and some are based on Boys’ Love manga (BL). BL is a distinct genre involving the intense descriptions of male-male intimate relations, where both authors and readers are predominantly heterosexual ciswomen. With the market success of these films and TV dramas, BL representations are becoming available to large audiences and are sometimes regarded as a source for the public to learn about LGBT issues, although many authors acknowledge that the representations in BL do not necessarily reflect the actuality of gay people. Some scholars and gay commentators have claimed that the dissemination of unrealistic descriptions by heterosexual female writers is discriminative, which would further marginalize and rhetorically appropriate sexual minorities. This chapter analyzes how BL is located in Japanese society amid the rise of LGBT awareness. It examines the representations of same-sex relationships in BL manga, the recent growth of the genre into forms of transmedia storytelling, and the debates on the representations of same-sex relations. Drawing on these analyses, I will argue that BL transmedia storytelling is a valuable space for creators from diverse media to collaboratively explore new forms of narratives and interpretations; but it could simultaneously disseminate distorted representations of same-sex relationships if they failed to adequately understand the nature of BL.
Migration Policy and Welfare Chauvinism in the United Kingdom: European Divergence or Trend-Setting?
Authors: D’Angelo Alessio 
Published: April 2023

AbstractGrowing hostility towards large-scale immigration following the EU enlargement (2004) and, later, the increase in South-North flows due to the global financial crisis (2008), played a major role in the Brexit referendum of 2016. This marked the departure of the United Kingdom from the European Union and from its mechanisms of “free movement”. Such hostility was not framed simply in terms of xenophobia but, rather, as “welfare chauvinism”. This chapter critically examines the last few decades of policy and political debates around intra-European migration in the United Kingdom, the key trends that have led to the (not so) unpredictable Brexit referendum, and the scenarios which have been set in motion with the UK-EU Agreement of 2020. In spite of the strong sense of British exceptionalism which has informed UK discussions, some of the fundamentals underpinning this process have much in common with what we are witnessing elsewhere in Europe, with the stratification of (welfare) rights for different categories of migrants being used as a pragmatic – if not cynical – mechanism to regulate entry and settlement. In fact, what at political and institutional level appears yet as the major rapture within the European framework, may end up revealing itself as part of a wider trend among both Northern and Southern European regimes: the restrictionist reconfiguration of the welfare-migration nexus. This race to the welfare bottom is not only affecting newly arrived migrants, but eroding the rights of the wider population.
Challenges and Ambiguities of the Policies for Immigrants’ Regularisation: The Portuguese Case in Context
Authors: Malheiros Jorge , Peixoto João 
Published: April 2023

AbstractThe idea that most immigrant receiving countries face a crisis of control has become pervasive since the 1990s, when neoliberal globalisation, as well as securitarian and nationalist policies, gained space. Due to the several contradictions and inefficiencies of the global circulation framework, most countries are exposed to uncontrolled migration, including the North and South European ones. The challenge is stronger when borders separate regions with uneven development levels and the economic cycle is expanding. When irregular migration occurs, the basic ex-post policy choices are limited to ignore the problem, enact deportation strategies or create mechanisms for regularisation.In Southern European countries, irregular immigration became endemic. Until the mid-2000s, the most frequent policy approach adopted in these migration regimes was the enactment of extraordinary regularisation processes. Since then, some nations adopted an ongoing regularisation model. Using Portugal as a reference, we intend to examine how such processes were implemented and why they have been enacted. Because the features of the Portuguese case share elements with other countries, some comparative analysis is developed and positioned at the global European level, to evaluate the convergence or divergence hypothesis and the blurring of migration regimes’ boundaries.
Knowledge Production Through Regularisation and Ex-Post Regulation Strategies: Italy and Germany Compared
Authors: Finotelli Claudia 
Published: April 2023

AbstractThis chapter addresses the use of regularisations and ex-post regulation measures as an instrument to produce knowledge on social problems. Regularisations, more than other migration regulation tools, were addressed to highlight the “efficacy gap” existing between Northern and Southern European control regimes and were the object of several confrontations between Northern and Southern European Member States. Especially in times of migration crises, the use of regularisations seemed to strengthen the stereotype on “weak” Southern European migration regimes, in which chaotic and unplanned regulation mechanisms dominate. Yet, in this chapter it is argued that the function of regularisations should be assessed beyond the dichotomic distinction between “weak” and “strong” migration control regimes in Southern and Northern Europe. Regularisations and ex-post regulation strategies should rather be observed as an instrument to overcome weak internal controls and to produce knowledge on the presence of irregular migrants. To this end, the Italian and German immigration regimes will be used as comparative examples since they represent two opposed migration patterns in Europe with opposed approaches to unauthorised residence. The aim of the comparison is not only to discuss how very different migration regimes produce knowledge on unauthorised residence on their territory, but also to highlight the importance of these measures for the stabilisation of precarious immigrant populations.
Correlation Between Endoglin and Malignant Phenotype in Human Melanoma Cells: Analysis of hsa-mir-214 and hsa-mir-370 in Cells and Their Extracellular Vesicles
Authors: Ruiz-Llorente Lidia , Ruiz-Rodríguez María Jesús , Savini Claudia , González-Muñoz Teresa , Riveiro-Falkenbach Erica , Rodríguez-Peralto José L. , Peinado Héctor , Bernabeu Carmelo 
Published: April 2023

AbstractEndoglin (CD105) is an auxiliary receptor of transforming growth factor (TGF)-β family members that is expressed in human melanomas. It is heterogeneously expressed by primary and metastatic melanoma cells, and endoglin targeting as a therapeutic strategy for melanoma tumors is currently been explored. However, its involvement in tumor development and malignancy is not fully understood. Here, we find that endoglin expression correlates with malignancy of primary melanomas and cultured melanoma cell lines. Next, we have analyzed the effect of ectopic endoglin expression on two miRNAs (hsa-mir-214 and hsa-mir-370), both involved in melanoma tumor progression and endoglin regulation. We show that compared with control cells, overexpression of endoglin in the WM-164 melanoma cell line induces; (i) a significant increase of hsa-mir-214 levels in small extracellular vesicles (EVs) as well as an increased trend in cells; and (ii) significantly lower levels of hsa-mir-370 in the EVs fractions, whereas no significant differences were found in cells. As hsa-mir-214 and hsa-mir-370 are not just involved in melanoma tumor progression, but they can also target endoglin-expressing endothelial cells in the tumor vasculature, these results suggest a complex and differential regulatory mechanism involving the intracellular and extracellular signaling of hsa-mir-214 and hsa-mir-370 in melanoma development and progression.
Constructing operator basis in supersymmetry: a Hilbert series approach
Authors: Delgado Antonio , Martin Adam , Wang Runqing 
Published: April 2023

Abstract
In this paper we introduce a Hilbert series approach to build the operator basis for a N = 1 supersymmetry theory with chiral superfields. We give explicitly the form of the corrections that remove redundancies due to the equations of motion and integration by parts. In addition, we derive the maps between the correction spaces. This technique allows us to calculate the number of independent operators involving chiral and antichiral superfields to arbitrarily high mass dimension. Using this method, we give several illustrative examples.
Mean-Field Limits for Entropic Multi-Population Dynamical Systems
Authors: Almi Stefano , D’Eramo Claudio , Morandotti Marco , Solombrino Francesco 
Published: April 2023

AbstractThe well-posedness of a multi-population dynamical system with an entropy regularization and its convergence to a suitable mean-field approximation are proved, under a general set of assumptions. Under further assumptions on the evolution of the labels, the case of different time scales between the agents’ locations and labels dynamics is considered. The limit system couples a mean-field-type evolution in the space of positions and an instantaneous optimization of the payoff functional in the space of labels.
Nonlesional epilepsy—a case report in adult epileptology
Authors: Sheybani Laurent , Spinelli Laurent , Egervari Kristof , Garibotto Valentina , Vargas Maria Isabel , Seeck Margitta , Vulliemoz Serge 
Published: April 2023

AbstractWe report the case of a patient with nonlesional, pharmacoresistant epilepsy. Bilateral synchronous discharges as well as focal discharges were identified on electroencephalogram (EEG). After non-invasive and invasive presurgical evaluation, a probable epileptogenic zone was identified with concordant results of focal origin involvement of the left temporal pole. Resective epilepsy surgery provided seizure freedom (last follow-up at 12 months). The case nicely illustrates that bilateral synchronous discharges or/and a lack of lesions on neuroimaging are not contraindications to presurgical evaluation of epilepsy, which on the contrary should be offered to all patients with pharmacoresistant epilepsy. The case also illustrates the importance of combining electrophysiological, imaging, and neuropsychological information to guide intracranial EEG placement and improve postsurgical outcome.
The Impact of Fruit Ripeness on the Lower Oxygen Limit, Chlorophyll Fluorescence and Fermentation Behavior in Apples
Authors: Schlie Tim-Pascal , Rath Thomas , Köpcke Dirk , Dierend Werner 
Published: April 2023

AbstractDynamic Controlled Atmosphere-Chlorophyll Fluorescence storage (DCA-CF) uses a fluorescence-based measurement method to detect fermentation in apples (Malus × domestica BORKH.) caused by low-oxygen levels at an early stage. In recent years, it has been observed that individual apples of the same variety and origin can exhibit different fermentation behavior when stored under completely identical conditions. The causes of the different fermentation behavior must be found in order to be able to use DCA storage optimally. This study aimed to find the causes of the different fermentation behaviors of individual apples. Our results show that fruit ripeness can affect the lower oxygen limit (LOL), especially immediately after harvest, when the starch degradation in the fruit is not yet complete. A significant increase in the LOL was observed in ‘Elstar’ (2020: 0.3 kPa, 0.6 kPa, 0.9 kPa; 2021: 0.3 kPa, 0.4 kPa, 0.6 kPa). ‘Braeburn’ also exhibited this behavior regarding the LOL at a lower level. The LOL could not be identified for some of the fruit (varying from 12.5% to 41.7% of the examined apples) previously stored in Ultra Low Oxygen (ULO) storage for 4 months. Also, the chlorophyll content in the apple skin influences the fluorescence measurement method. Within 2 weeks, the chlorophyll content in the apple skin was halved. If the chlorophyll content drops, the reliability of the fluorescence measurement also decreases. It turned out that apples with an Fv/Fm < 0.7 were unsuitable for valid LOL identification.
A Bayesian model of legal syllogistic reasoning
Authors: Constant Axel 
Published: April 2023

AbstractBayesian approaches to legal reasoning propose causal models of the relation between evidence, the credibility of evidence, and ultimate hypotheses, or verdicts. They assume that legal reasoning is the process whereby one infers the posterior probability of a verdict based on observed evidence, or facts. In practice, legal reasoning does not operate quite that way. Legal reasoning is also an attempt at inferring applicable rules derived from legal precedents or statutes based on the facts at hand. To make such an inference, legal reasoning follows syllogistic logic and first order transitivity. This paper proposes a Bayesian model of legal syllogistic reasoning that complements existing Bayesian models of legal reasoning using a Bayesian network whose variables correspond to legal precedents, statutes, and facts. We suggest that legal reasoning should be modelled as a process of finding the posterior probability of precedents and statutes based on available facts.
(mis)-Targeting of SWI/SNF complex(es) in cancer
Authors: Reddy Divya , Bhattacharya Saikat , Workman Jerry L. 
Published: April 2023

AbstractThe ATP-dependent chromatin remodeling complex SWI/SNF (also called BAF) is critical for the regulation of gene expression. During the evolution from yeast to mammals, the BAF complex has evolved an enormous complexity that contains a high number of subunits encoded by various genes. Emerging studies highlight the frequent involvement of altered mammalian SWI/SNF chromatin-remodeling complexes in human cancers. Here, we discuss the recent advances in determining the structure of SWI/SNF complexes, highlight the mechanisms by which mutations affecting these complexes promote cancer, and describe the promising emerging opportunities for targeted therapies.
GABAA receptor-mediated seizure liabilities: a mixed-methods screening approach
Authors: Bampali Konstantina , Koniuszewski Filip , Vogel Florian D. , Fabjan Jure , Andronis Christos , Lekka Eftychia , Virvillis Vassilis , Seidel Thomas , Delaunois Annie , Royer Leandro , Rolf Michael G. , Giuliano Chiara , Traebert Martin , Roussignol Gautier , Fric-Bordat Magali , Mazelin-Winum Ludmilla , Bryant Sharon D. , Langer Thierry , Ernst Margot 
Published: April 2023

AbstractGABAA receptors, members of the pentameric ligand-gated ion channel superfamily, are widely expressed in the central nervous system and mediate a broad range of pharmaco-toxicological effects including bidirectional changes to seizure threshold. Thus, detection of GABAA receptor-mediated seizure liabilities is a big, partly unmet need in early preclinical drug development. This is in part due to the plethora of allosteric binding sites that are present on different subtypes of GABAA receptors and the critical lack of screening methods that detect interactions with any of these sites. To improve in silico screening methods, we assembled an inventory of allosteric binding sites based on structural data. Pharmacophore models representing several of the binding sites were constructed. These models from the NeuroDeRisk IL Profiler were used for in silico screening of a compiled collection of drugs with known GABAA receptor interactions to generate testable hypotheses. Amoxapine was one of the hits identified and subjected to an array of in vitro assays to examine molecular and cellular effects on neuronal excitability and in vivo locomotor pattern changes in zebrafish larvae. An additional level of analysis for our compound collection is provided by pharmacovigilance alerts using FAERS data. Inspired by the Adverse Outcome Pathway framework, we postulate several candidate pathways leading from specific binding sites to acute seizure induction. The whole workflow can be utilized for any compound collection and should inform about GABAA receptor-mediated seizure risks more comprehensively compared to standard displacement screens, as it rests chiefly on functional data.
Country differentiation in the global environmental context: Who is ‘developing’ and according to what?
Authors: Farias Deborah Barros Leal 
Published: April 2023

AbstractSeveral multilateral treaties and International Governmental Organizations have introduced different legal obligations for countries based on the developing/developed (or equivalent) dichotomy. Such differentiation can (re)produce a range of material and symbolic consequences for those labelled developing or developed. Much has been researched about this topic in the environmental regime yet an important gap remains: what does this differentiation look like empirically? This article answers this question through a qualitative analysis that compares about two dozen multilateral environmental agreements (MEAs) on (1) how they specify what makes a country be developing (or not) and (2) the result of this choice, that is, exactly which countries are labelled developing under each MEA. The research reveals at least four important points: (1) the absence of any converging approach to classifying countries in the global environmental context; (2) almost 1 out of 4 countries in the world have mixed classification (developing or developed depending on the MEA); (3) ‘switching’ groups is relatively infrequent, but can be both moving to or away from the developing label; and (4) most countries with mixed classifications appear to be comfortable in the situation. This research contributes to a finer-grained understanding of differentiation in global environmental governance.
Clinical and laboratory key performance indicators in IVF: A consensus between the Italian Society of Fertility and Sterility and Reproductive Medicine (SIFES-MR) and the Italian Society of Embryology, Reproduction and Research (SIERR)
Authors: Vaiarelli Alberto , Zacà Carlotta , Spadoni Valentina , Cimadomo Danilo , Conforti Alessandro , Alviggi Carlo , Palermo Roberto , Bulletti Carlo , De Santis Lucia , Pisaturo Valerio , Vigiliano Vincenzo , Scaravelli Giulia , Ubaldi Filippo Maria , Borini Andrea 
Published: April 2023

Abstract

Purpose
Infertility is increasing worldwide, and many couples seek IVF. Clinical management and laboratory work are fundamental in the IVF journey. Therefore, the definition of reliable key performance indicators (KPIs) based on clinical and laboratory parameters, is essential for internal quality control (IQC). Laboratory performance indicators have been identified and a first attempt to also determine clinical ones has been recently published. However, more detailed indicators are required.

Methods
An Italian group of experts in Reproductive Medicine from both public and private clinics on behalf of SIFES-MR and SIERR was established to define IVF indicators to monitor clinical performance.

Results
The working group built a consensus on a list of KPIs, performance indicators (PIs) and recommendation indicators (RIs). When deemed necessary, the reference population was stratified by woman age, response to ovarian stimulation and adoption of preimplantation genetic testing for aneuploidies (PGT-A). Each indicator was scored with a value from 1 to 5 and a weighted average formula – considering all the suggested parameters—was defined. This formula generates a center performance score, indicating low, average, good, or excellent performance.

Conclusion
This study is intended to provide KPIs, PIs and RIs that encompass several essential aspects of a modern IVF clinic, including quality control and constant monitoring of clinical and embryological features. These indicators could be used to assess the quality of each center with the aim of improving efficacy and efficiency in IVF.