bluuebunny/crossref_metadata_2025_split huggingface dataset:
Recent Trends on Production Sources, Biosynthesis Pathways and Antiviral Efficacies of Artemisinin: A Candidate Phytomedicine against SARS-CoV-2
Authors: Hussain Adil 
Published: March 2023

Background:Artemisinin is a lactone sesquiterpenoid with an endo-peroxide bridge in the 1, 2, 3-trioxane structure employed for the treatment and management of lethal viral diseases. In the current review, emphasis has been given on the production of artemisinin from natural sources with biosynthesis pathways and potential antiviral activity.Methods:A wide-ranging inquiry on artemisinin was made electronically on the basis of articles published in peer-reviewed journals, abstracts, published in conference proceedings, government reports, preprints, books, Master’s and Ph.D. theses, etc. The research was carried out in different International scientific databases like Academic Search, Biological Abstracts, BIOSIS, BioOne Previews, CabDirect, Cochrane Library, Pubmed/Medline, GeoRef, Google Scholar, JSTOR, Journal Citation Reports, Mendeley, Publons, Researchgate, Scopus, SciELO, Springer Link, Science Direct, Web of Science, Taylor and Francis with particular keywords.Results:The evidence reviewed here indicates that out of the hundreds of species of the genus Artemisia mentioned in the literature, only 37 Artemisia species are reported to possess artemisinin naturally in their extracts with variable concentrations. This review further discusses the biosynthesis pathways and antiviral activities of artemisinin and its derivatives which have been used against more than 12 viral disease categories.Conclusion:On the whole, it is concluded that the primary natural sources of artemisinin and its derivatives are the Artemisia plants with antiviral activity, which are essential candidates for drug development against SARS-CoV-2 mainly from those Artemisia species screened for SARS-CoV- 2 infection.
A Novel Mobile App to Identify Patients With Multimorbidity in the Emergency Setting: Development of an App and Feasibility Trial
Authors: Rosen Claire Barthlow , Roberts Sanford Eugene , Syvyk Solomiya , Finn Caitlin , Tong Jason , Wirtalla Christopher , Spinks Hunter , Kelz Rachel Rapaport 
Published: March 2023

Background
Multimorbidity is associated with an increased risk of poor surgical outcomes among older adults; however, identifying multimorbidity in the clinical setting can be a challenge.

Objective
We created the Multimorbid Patient Identifier App (MMApp) to easily identify patients with multimorbidity identified by the presence of a Qualifying Comorbidity Set and tested its feasibility for use in future clinical research, validation, and eventually to guide clinical decision-making.

Methods
We adapted the Qualifying Comorbidity Sets’ claims-based definition of multimorbidity for clinical use through a modified Delphi approach and developed MMApp. A total of 10 residents input 5 hypothetical emergency general surgery patient scenarios, common among older adults, into the MMApp and examined MMApp test characteristics for a total of 50 trials. For MMApp, comorbidities selected for each scenario were recorded, along with the number of comorbidities correctly chosen, incorrectly chosen, and missed for each scenario. The sensitivity and specificity of identifying a patient as multimorbid using MMApp were calculated using composite data from all scenarios. To assess model feasibility, we compared the mean task completion by scenario to that of the American College of Surgeons National Surgical Quality Improvement Program Surgical Risk Calculator (ACS-NSQIP-SRC) using paired t tests. Usability and satisfaction with MMApp were assessed using an 18-item questionnaire administered immediately after completing all 5 scenarios.

Results
There was no significant difference in the task completion time between the MMApp and the ACS-NSQIP-SRC for scenarios A (86.3 seconds vs 74.3 seconds, P=.85) or C (58.4 seconds vs 68.9 seconds,P=.064), MMapp took less time for scenarios B (76.1 seconds vs 87.4 seconds, P=.03) and E (20.7 seconds vs 73 seconds, P<.001), and more time for scenario D (78.8 seconds vs 58.5 seconds, P=.02). The MMApp identified multimorbidity with 96.7% (29/30) sensitivity and 95% (19/20) specificity. User feedback was positive regarding MMApp’s usability, efficiency, and usefulness.

Conclusions
The MMApp identified multimorbidity with high sensitivity and specificity and did not require significantly more time to complete than a commonly used web-based risk-stratification tool for most scenarios. Mean user times were well under 2 minutes. Feedback was overall positive from residents regarding the usability and usefulness of this app, even in the emergency general surgery setting. It would be feasible to use MMApp to identify patients with multimorbidity in the emergency general surgery setting for validation, research, and eventual clinical use. This type of mobile app could serve as a template for other research teams to create a tool to easily screen participants for potential enrollment.
Fluid Management for Critically Ill Patients with Acute Kidney Injury Receiving Kidney Replacement Therapy
Authors: Ledoux-Hutchinson Lawrence , Wald Ron , Malbrain Manu L.N.G. , Carrier François Martin , Bagshaw Sean M. , Bellomo Rinaldo , Adhikari Neill K.J. , Gallagher Martin , Silver Samuel A. , Bouchard Josée , Connor Jr Michael J. , Clark Edward G. , Côté Jean-Maxime , Neyra Javier A. , Denault André , Beaubien-Souligny William 
Published: March 2023

Background
In critically ill patients receiving KRT, high ultrafiltration rates and persistent fluid accumulation are associated with adverse outcomes. The purpose of this international survey was to evaluate current practices and evidence gaps related to fluid removal with KRT in critically ill patients.

Methods
This was a multinational, web-based survey distributed by seven networks comprising nephrologists and intensivists. Physicians involved in the care of critically ill patients were invited to complete a 39-question survey about fluid management practices on KRT. The survey was distributed from September 2021 to December 2021.

Results
There were 757 respondents from 96 countries (response rate of 65%). Most respondents practiced adult medicine (89%) and worked in an academic center (69%). The majority (91%) reported aiming for a 0.5- to 2-L negative fluid balance per day when fluid removal is indicated, although there was important variability in what respondents considered a safe maximal target. Intensivists were more likely than nephrologists to use adjunct volume status assessment methods (i.e., ultrasound, hemodynamic markers, and intra-abdominal pressure), while nephrologists were more likely to deploy cointerventions aimed at improving tolerance to fluid removal (i.e., osmotic agents and low-temperature dialysate). There was a broad consensus that rapid decongestion should be prioritized when fluid accumulation is present, but the prevention of hypotension was also reported as a competing priority. A majority (77%) agreed that performing trials that compare fluid management strategies would be ethical and clinically relevant.

Conclusions
We have identified multiple areas of variability in current practice of fluid management for patients receiving KRT. Most nephrologists and intensivists agreed that several knowledge gaps related to fluid removal strategies should be investigated in future randomized controlled trials.
¿Cómo contribuir, desde los nuevos escenarios sociales del siglo XXI, a una educación matemática accesible a las capacidades de todas y cada una de las personas?
Authors: Díaz Cynthia Marianela , Kovacic Gregorczuk María Victoria , Malik De Tchara Claudia , García Valeria Lourdes 
Published: March 2023

El presente informe es realizado, en el marco del Proyecto de Investigación “Recursos didácticos para la enseñanza de la matemática en aulas inclusivas”, por recientes graduadas que comenzaron a participar del Proyecto siendo aún estudiantes de la carrera Profesorado para la Educación Primaria.
El proceso de formación de las estudiantes que participan en el Proyecto de Investigación mencionado articula la teoría y la práctica, es así que en el marco de la beca se apunta a que la tarea de investigación se sostenga con materiales que permitieran vincular el marco teórico objeto de investigación, las prácticas necesarias para el logro de los objetivos planteados y el abordaje metodológico que combina aspectos cualitativos y cuantitativos partiendo de la hipótesis central, que surge en el marco de una educación inclusiva y la contextualización del planteo de Cobeñas y Grimaldi (2017): ¿qué podemos pensar y hacer desde la Universidad, como colectivo de docentes, para enseñar Matemática en Aulas Inclusivas? En este contexto se constituye un espacio de producción y reflexión colectiva y se apunta a la incorporación de conocimientos acerca de las nuevas configuraciones de los escenarios sociales en el siglo XXI, que contribuyan a la problematización de la realidad social y educativa.
Reconociendo que el campo de la Educación Inclusiva está cubierto de incertidumbres, disputas y contradicciones, el análisis que se desarrolla busca dar respuesta a cómo contribuir a que la Educación Matemática sea accesible a las capacidades de todos/as los/as niños, jóvenes y adultos/as, pensando primeramente en el cómo incluir y cómo enseñar con equidad y justicia basada en la igualdad y valía de todos los seres humanos.
The fate of the Dead Sea: total disappearance or a hypersaline lagoon
Authors: Oroud Ibrahim 
Published: March 2023

An energy balance model run on a monthly time step for 800 years was
developed to predict the future level and areal extent of the Dead Sea
under different scenarios of freshwater input and boundary conditions.
The model integrates energy, water and salt balances. The bathymetry of
the Dead Sea was obtained from digital elevation data derived from a
high-resolution contour map. Model results were verified against
measured lake level for the period 1928 through 2022. Predicted levels
are very close to observed values as demonstrated by three statistical
measures. The monthly temperatures of the mixed layer as predicted by
the model were also commensurate with observational results and
atmospherically corrected surface temperatures retrieved from the
thermal band onboard Landsat 8. Simulation results show that the Dead
Sea level will range from ~ 510 m below sea level (m
bsl) when freshwater input is ⁓400 × 10
m a to 585 m bsl when
precipitation is the only freshwater source reaching the lake. The time
span needed for the Dead Sea to reach a quasi-steady state equilibrium,
that is when consecutive simulated annual cycles are identical- is
several hundred years.
Production of biogas using waste products (Water Hyacinth and Cow Dung)
Authors: Archibong Ekong, Emem , Ekanim Mary 
Published: March 2023

This research was carried out to make use of water hyacinth to produce
biogas which may solve the problem of water hyacinth management as well
as provide a solution to energy and power shortages. Samples of
water-hyacinth were identified and collected and the cow dung was
obtained from an abattoir. One (1) single 120 improvised rubber cylinder
can be used as an anaerobic. Three (3) of water was added for the 30
days retention time. The cow dung was mixed with water at a ratio of 3 :
1. The slurry of cow dung and water hyacinth substrates was then fed to
the for the fermentation process to begin. Experiments were carried out
during the cool season and dry season (20– 40C). The
gas was collected and stored in the gas bag. The volume of was measured
using an EL- STER HANDEL GMBH MAINZ volumetric meter, which has a limit
of detection of less than 0.0010m. The products
obtained from the anaerobic digestion of water hyacinth were the compost
that is removed from the at the end of the digestion process. The
study’s evaluation of production potential over a 30 days period
revealed marked seasonal variations in biogas outflow.
ANALISIS SIFAT MEKANIK LIST GYPSUM BERBASIS SERAT BATANG KELOR
Authors: Masthura Masthura , Jumiati Ety , Malika Tri Ninda 
Published: March 2023

Telah dilakukan penelitian list gypsum berbahan serat batang kelor. Penelitian ini bertujuan untuk mengetahui sifat uji mekanik dari list gypsum berbahan serat batang kelor, Variasi komposisi campuran serat batang kelor dan tepung gipsum antara lain 0% : 100%, 2% : 98%, 4% : 96%, 6% : 94%, 8% : 92%, 10% : 90% dengan FAS 0,5. Proses pembuatan sampel list gypsum menggunakan hot press dengan suhu 90oC dan waktu 30 menit. Parameter pengujian sifat mekanik yaitu uji kuat lentur dan kuat patah. Dari hasil pengujian menunjukkan bahwa list gypsum berbahan serat batang kelor memiliki nilai kuat lentur sebesar 140105,4181-484416,5492 kgf/cm2 dan nilai kuat patah sebesar 788,1-2016,9 kgf/cm2, sehingga kuat lentur dan kuat patah sesuai dengan standar mutu papan serat yaitu SNI 01-4449-2006.
PENGARUH VARIASI PENAMBAHAN DOPING Mg TERHADAP STRUKTUR DAN MORFOLOGI TiO2
Authors: Lubis Ridwan Yusuf , Husnah Miftahul 
Published: March 2023

Air merupakan salah satu kebutuhan manusia dalam melakukan kegiatan sehari -hari. Belakangan ini pencemaran air merupakan hal serius yang harus ditangani dalam upaya penjernihan agar dapat digunakan. Metode fotokatalis merupakan salah satu metode yang digunakan dalam upaya penjernihan air. Salah satu material fotokatalis yang sering digunakan adalah TiO2 dikareanakan sifat yang tidak beracun, ketersediaan melimpah dan memiliki nilai bandgap yang rendah. Untuk menurunkan nilai bandgap dari TiO2 dengan cara menambahkan doping logam transisi seperti Mg yang sudah terbukti dapat menurunkan nilai bandgap tanpa mengubah struktur TiO2 sebagai matriks. Metode pencampuran TiO2 dan doping Mg menggunakan metode solid state reaction. Doping Mg dicampurkan dengan cariasi x = 0 (A) , 2 (B) , 4 (C) dan 6 (D) wt%. Hasil analisa XRD dari hasil pengujian dapat dilihat bahwa muncul puncak pada sudut 2-theta berkisar di 25,5330o – 25,3930o. Terjadi penurunan sudut puncak ke sebelah kiri yang disebabkan telah tercampurnya doping Mg terhadap matriks TiO2. Ukuran kristal bertambah besar seiring dengan meningkatnya jumlah doping Mg yang dicampurkan kedalam TiO2 berkisar 3,4859Å - 3,5048Å . Hasil uji SEM menunjukkan bahwa penyebaran pada sampel D lebih merata dan tidak banyak terjadi aglomerasi sehingga memiliki permukaan yang lebih luas di banding sampel dengan jumlah variasi doping yang lebih rendah. Semakin banyak doping Mg yang dicampurkan maka kualitas dari material fotokatalis semakin bagus.
Environmental Disturbances in Counties from the Region of “Agreste” in the State of Pernambuco, and the Governmental Actions to Minimize Them, According to Counties’ Managers
Authors: Pedrosa Ivo Vasconcelos , Corrêa Cristiano 
Published: March 2023

Purpose: analyze the recent environmental changes and monitor programs of local governments.

Theoretical framework: is supported by literature on the maturity level of sustainability and sustainable.

Method/design/approach: the most populated municipalities of Pernambuco in the mid-dry region of the state were investigated by applying the same questionnaire and interviews used in all Brazil by Instituto Brasileiro de Geografia e Estatística (IBGE) in 2002.

Results and conclusion: Based on the questionnaires, two indices were generated: Anthropic Pressures Index and Anthropic Pressures Mitigation Index. It is proven, from the data, an increase of impacts and a reduced number of local policies.

Research implications: the lack of studies of the environmental situation in the municipalities of Pernambuco is noteworthy, as well as the absence of environmental policies to address these negative impacts.

Originality/value: one of the most debated topics nowadays has been the human impacts on the natural environment. In this respect, public policies aimed at mitigation have been insufficient.
Normalized Difference Vegetation Index Analysis Using Ndvi and Savi Indices in the Conservation Unit Serra da Borborema Municipal Nature Park, Campina Grande, Paraíba, Brazil
Authors: Fontgalland Isabel Lausanne , De Menezes Glaucio Costa , Paz Múcio Antônio de França , Souza Ênio Pereira de , Farias Soahd Arruda Rached , Rêgo Veneziano Guedes de Sousa 
Published: March 2023

The nature conservation units (UC) are specially protected territorial spaces (ETEP), with creation, implementation and management provided for by Law 9985/2000, which established the National System of Conservation Units (SNUC). Over 28% of the Brazilian territory is set aside for nature conservation, in a universe of over 2,300 established Units. Paraiba, Northeast region, has 15 (fifteen) Protected Units, representing less than 1% of its territory, and the Municipal Natural Park of Serra da Borborema, classified as Full Protection UC, located in the eastern part of the city of Campina Grande, at coordinates Lat. (S) 07º23'250" and Log. (W) 35º84'331", is the only local UC.

Objective: to analyze the vegetation cover of the Park through the: Normalized Difference Vegetation Index (NDVI) and the Soil Adjusted Vegetation Index (SAVI), in the period from June to September 2020.

Theoretical Frame: It was used citations and authors, respecting the quadrennium 2019 and 2022, being the main ones listed here: Ministry of Environment, WWF, IUCN, IBAMA and, Felix-Trigueiro & Fontgalland, favoring the understanding of concepts related to the protected area and the environmental conservation in the Poeta's Park in Campina Grande -Brazil, and the studies of Ponzoni et al. for the weighting of the derivations of sensorial studies of vegetation.

Method: two forms of index analysis were proposed: data and geoprocessed images from LandSat8 satellite, provided by the US Geological Survey - USGS, using Qgis 3.10 software.

Results and Conclusions: despite the difference in the representation of minimum and maximum values between the indices evaluated in the thematic maps, as a result, the NDVI and SAVI vegetation indices were close to 1, so that it can be inferred that from the analysis of the biophysical resource "vegetation cover" of the locality, it can allow the conservation of the area for the maintenance of its ecosystem services available to the region, despite the anthropic pressure suffered at the site.

Implications of the research: The research is classified as extremely appropriate to the interests of the Post-graduate Program of the Federal University of Campina Grande and also corroborates as literature for other research groups in the Northeast that are involved with protected areas and analysis of vegetation index.

Originality and value: The work is pointed out as essential because its differential are the analyses through NDVI and SAVI indexes adapted to the complex of the poet's park in Campina Grande-Brazil.
A Study on the Projection of Drinking Water 2023-2033 in Dki Jakarta Indonesia
Authors: Fikri Elanda , Fauzi Mhd. , Firmansyah Yura Witsqa 
Published: March 2023

Purpose: The purpose of this research is to analyze the drinking water needs and raw water availability of DKI Jakarta Province.

Theoretical framework: The theoretical basis for the population projections uses mathematical modeling (arithmetic, logarithmic, exponential, and geometric) for the next 10 years. Drinking water demand projections are obtained by calculating the demand for drinking water and the results of the population projections. Then compared to raw water availability. Potable water demands are calculated based on design criteria

Method/design/approach: The method used is research and development by projecting the population of the last 10 years to predict the population of the next 10 years. The total projected drinking water needs obtained were compared with the availability of raw water.

Results and conclusion: The results show that the demand for drinking water in DKI Jakarta in 2023 will be 30,892 liters/second, while the raw water capacity will only be 16,850. This shows that the level of drinking water service in DKI Jakarta is only 54.54%. When compared to 2015, DKI Jakarta's drinking water access service decreased from 65.13% in 2015 to 54.54% in 2023.

Research implications: If DKI Jakarta does not succeed in finding raw water sources, it is estimated that drinking water services will drop dramatically to 35.68% in 2033.

Originality/value: Studies on the projection of drinking water in DKI Jakarta, Indonesia for the next 10 years have not been conducted. So this study has good originality and becomes a study with high novelty. This study can also be utilized by DKI Jakarta government authorities in formulating environmental and health management policies.
Local State Capacity: an Analysis of Bureaucracy’ Professionalization Level and its Eflection on Development
Authors: Dos Passos Paulo Martins , Dib Bruno Barbosa , Machado Júnior Eliseu Vieira , De Oliveira Bruno Garcia , Petean Gustavo Henrique 
Published: March 2023

Purpose: The current Brazilian State, after a context of patrimonialist formation, seeks to mold itself into a bureaucratic model with significant fragments of managerialism. Concerning to the public management efficiency discussion, the article aims to analyze the technical-administrative state capacity and the development of Goiás State municipalities.

Theoretical framework: The theoretical bases for building the concept of state capacity and local development were presented. The articulation of this theoretical framework took place concerning the transition from the patrimonial to the managerial state. Emphasis was placed on historicity and the current conception of the public agent civil and the bureaucratic elements that surround him and, finally, the intersections that underlie the development of the public entity.

Method/design/approach: Data from the Municipality Performance Index and the IBGE Municipal Basic Information Survey were used. The methodological approach was based on cluster analysis, descriptive statistics and Pearson's correlation coefficient.

Results and conclusion: The results showed that the economic data bundling assists typologies creation of homogeneous municipalities for development analysis, highlighting those that are more dependent on the local public administration.

Research implications: It was found that, in a significant number of municipalities, there is a positive correlation between state capacity, professionalization of bureaucracy and development.

Originality/value: The results indicate that greater municipal development can be achieved by improving the technical-administrative state capacity and the public service through the professionalization of the bureaucracy.
Circular economy and Opportunities for Small and Medium Enterprises in Lather Industry of Sialkot Pakistan
Authors: Abidin Zain Ul , Qammar Rabia , Gill Fozia Latif 
Published: March 2023

Purpose: The purpose of this study is to find the opportunities/ benefits and barriers for the implementation of circular economy in lather manufacturing small and medium enterprises in Sialkot Pakistan.
Methodology: The present study is qualitative and semi-structured interviews were conducted with production managers. Thematic analysis technique was applied.
Findings: It was found that lack of public awareness is a major barrier and resource-saving is the major benefit or opportunity for small-medium enterprises for the implementation of a circular economy.
Implications: The practical implication of study through environmental protection is how a firm can gain its market share.