bluuebunny/crossref_metadata_2025_split huggingface dataset:
Telerehabilitation for visual field defects with a multisensory training: a feasibility study
Authors: Bolognini Nadia , Diana Lorenzo , Rossetti Angela , Melzi Lisa , Basso Gianpaolo , Manzo Vittorio , Cruz-Sanabria Francy , Cammarata Gabriella , Cernigliaro Franco , Bianchi Marzoli Stefania , Tinelli Francesca , Fiori Simona , Casati Carlotta 
Published: February 2025

Abstract

Background
Acquired homonymous visual field defects (HVFDs) result in significant disability, reducing quality of life. Spontaneous recovery occurs within the first months, then the likelihood of vision recovery decreases, making rehabilitation necessary. HVFDs rehabilitation is typically lengthy and intensive, done on an outpatient basis, hardly compatible with the return to everyday life. Telerehabilitation represents an option for continuing the therapy in the chronic phase of the disease, offering long-term support after hospital discharge. It also allows individuals with HVFDs to exercise independently, intensively, and actively at home, in a familiar environment, under remote supervision. However, the efficacy of telerehabilitation for chronic HVFDs in adults still requires empirical support.

Methods
This single-arm clinical trial assesses the efficacy of a home-based, remote-supervised, compensatory audio-visual training (AVT) in 26 adults with chronic HVFDs following a brain lesion. Immediate and long-term (up to 6 months) effects on visual field scanning, reading, activities of daily living and mood were assessed. Predictors of treatment-induced gains were also investigated considering behavioral, neuro-ophthalmological (visual field perimetry and visual evoked potentials) and neuroradiological variables (structural imaging of grey- and white-matter damages). Finally, the efficacy of the home-based AVT was compared to that of its in-person version (16 new participants with chronic HVFDs).

Results
Home-based AVT improves accuracy and speed of visual search, reading, mood, and disability in the activities of daily living, with improvements persisting up to 6 months after the end of the training (baseline vs. post-training assessments, all ps < 0.04). Post-treatment gains correlate with the severity of visual search deficit and the efficiency of multisensory integration (rs = -0.7/-0.5, all ps < 0.04). Neuro-ophthalmological and neuroradiological (structural connectivity) parameters are unaffected by the AVT, in line with its compensatory nature, although being associated to its efficacy (all ps < 0.03). Finally, the telerehabilitation version of the AVT produces effects comparable to the in-person AVT.

Conclusion
Multisensory training delivered in telerehabilitation is feasible and effective for ameliorating oculomotor compensation of visual field loss, improving mood and reducing functional disabilities in adults with chronic HVFDs.

Trial registration This study was retrospectively registered at clinicaltrials.gov (NCT06341777; 26/03/2024).
Comorbidity of diarrhea and respiratory infection symptoms, and associated factors among under-five children in Gondar City, Northwest Ethiopia: a community-based cross-sectional study
Authors: Demoze Lidetu , Dessie Awrajaw , Azanaw Jember , Yitageasu Gelila , Asrat Kidist , Gizaw Zemichael 
Published: February 2025

Abstract

Background
Childhood morbidity is frequently characterized by more than one health condition. Children under the age of five in low- and middle-income countries including Ethiopia experience multiple episodes of diarrhea and respiratory infection symptoms. However, there have been limited studies on comorbidities of diarrhea and respiratory infection symptoms. In addition, most studies conducted in Ethiopia seek separate outcomes for diarrhea and respiratory infection symptoms. Therefore, this study aimed to determine the prevalence of diarrhea and respiratory infection symptoms comorbidity, and associated factors among under-five children in Gondar City.

Methods
Community-based cross-sectional study was conducted in Gondar City among under-five children from April 05 – May 04, 2023. Multi-stage sampling technique was used to collect a sample of 836. A structured questionnaire was employed through an interview-administered method for data collection at participants’ homes. Bivariable and multivariable binary logistic regression analyses were undertaken to identify predictors of childhood comorbidity of diarrhea and respiratory infection symptoms.

Results
The comorbidity prevalence of diarrhea and respiratory infection symptoms in under-five children was 17.22% [CI: 14.8%-19.9%]. Mothers/caretaker age < 25 years (AOR = 3.52 at 95% CI:1.64,7.5), mothers/caretakers who had no formal education (AOR = 4.42 at 95% CI: 2.08,9.9.40), family size > 5 (AOR = 4.52 at 95% CI: 2.13,9.61), second birth order (AOR = 2.67 at 95% CI: 1.31,5.41), children playground not clean(AOR = 2.19 at 95% CI:1.01,4.71), started supplementary feeding at age > 6 months (AOR = 4.51 at 95% CI:1.50,13.58), mothers/caretakers who didn’t wash their hands after visiting latrine (AOR = 2.03 at 95% CI: 1.03,4.03), mothers/caretakers who didn’t wash their hands with soap and water (AOR = 1.92 at 95% CI: 1.00,3.69) were significantly associated factors with under five children comorbidity of diarrhea and respiratory infection symptoms.

Conclusions
According to the findings, the prevalence of diarrhea and respiratory infection symptoms comorbidity was higher and variation in the amount of comorbidity is explained by maternal and child predictors. Educating mothers/caregivers about hand washing, sanitation, hygiene, and supplementary feeding is a key approach for the prevention and control of comorbidities in children.
HnRNPC triggers the degradation of MITA to suppress the interferon-mediated antiviral response
Authors: Zhang Yanwei , Jia Zhao , Yuan Gaoliang , Chen Kangyong , Cen Jing , Wang Junya , Feng Hao , Adamek Mikolaj , Zou Jun 
Published: February 2025

Abstract
Heterogeneous nuclear ribonucleoproteins (hnRNPs) are a group of 34–120 kDa nuclear proteins that have recently been reported to participate in virus replication. The hnRNP family contains approximately 20 members, including hnRNP A1, hnRNP A2, hnRNP A2B1, hnRNPC, hnRNPD and hnRNPK. HnRNPC plays important roles in RNA biology, including expression, stability, mRNA splicing, nonspecific sequence export and 3’-end processing; however, the mechanisms underlying hnRNPC regulatory roles are not fully understood. Here, we found that zebrafish hnRNPC promoted spring viraemia of carp virus (SVCV) replication by increasing the stability of SVCV phosphoprotein while inhibiting the K48-linked ubiquitination of virus phosphoprotein, thereby suppressing the type I interferon (IFN) response. Mechanistically, hnRNPC could interact with the mediator of IFN regulatory factor 3 activation (MITA) to activate K48-linked ubiquitination for MITA degradation through the C-terminal domain of hnRNPC. We also showed that human hnRNPC could interact with MITA and that the overexpression of human hnRNPC decreased MITA protein in HEK293 cells, suggesting that the negative regulatory effects of hnRNPC on the type I IFN response are evolutionarily conserved. Collectively, our data indicate that hnRNPC promotes virus replication by suppressing IFN production activated by MITA and increasing the availability of viral proteins. Our work reveals an evolutionarily conserved mechanism that controls the IFN-mediated antiviral response by a member of the hnRNP family in vertebrates.
An investigation of the specificity and vividness of autobiographical memories and future events produced in response to disgust-related cues among individuals with eating disorders
Authors: Bektas Sevgi , Haslam Rowan , Hilton Shannon , Himmerich Hubertus , Cardi Valentina , Treasure Janet , Keeler Johanna Louise 
Published: February 2025

Abstract

Background
A deficiency in autobiographical memory functioning could be of relevance to the maintenance of an eating disorder (ED). Past research has found that people with EDs have difficulties in recalling specific details of autobiographical memories (AM) and in imagining future events. Our aim was to investigate AM and episodic future thinking (EFT) in individuals with anorexia nervosa (AN), binge-type eating disorders (Bulimia Nervosa or Binge Eating Disorders; BN/BED), and healthy controls (HCs) using negative cue words relevant to the experience of being disgusted and morally violated.

Methods
Remotely administered computerised versions of the autobiographical memory task (AMT) and the EFT task were used to measure the specificity and vividness of AMs and EFTs. Neutral or negative/moral disgust-relevant cues were used to elicit AMs and EFTs. The relationship between AM specificity and EFT specificity was explored. The predictor role of individual differences in childhood teasing and betrayal sensitivity on the specificity and vividness of AMT and EFTs induced by moral disgust-relevant cues was examined.

Results
Individuals with AN and BN/BED did not have difficulties retrieving specific and vivid details of AMs and imagining future events in both cue conditions. AM specificity predicted EFT specificity in AN and HC groups. Future events primed by neutral cues were rated as more vivid by the control group compared to those induced by negative cues. Participants with EDs who had greater levels of childhood teasing and betrayal sensitivity generated more vivid AMs and EFTs in response to moral disgust-related cues, which was not observed in HCs.

Conclusions
This study did not detect alterations in AMT and EFT characteristics in people with AN or binge-type EDs compared with HCs. The findings were discussed regarding sample characteristics (e.g., illness severity, ethnicity) and methodology (e.g., cue words) in the present study. Individual differences in childhood teasing and betrayal sensitivity may be related to more vivid negative memories and future events, which might increase the salience of past and future victimisation-related events.
Toll-like receptor 3: a double-edged sword
Authors: Hsieh Marvin L , Nishizaki Daisuke , Adashek Jacob J , Kato Shumei , Kurzrock Razelle 
Published: February 2025

Abstract
The discovery of Toll-like receptors (TLRs) and their role in dendritic cells earned the Nobel Prize for 2011 because TLRs profoundly enhanced our understanding of the immune system. Specifically, TLR3 is located within the endosomal compartments of dendritic cells and plays a crucial role in the immune response by acting as a pattern recognition receptor that detects both exogenous (viral) and endogenous (mammalian) double-stranded RNA. However, TLR3 activation is a double-edged sword in various immune-mediated diseases. On one hand, it can enhance anti-viral defenses and promote pathogen clearance, contributing to host protection. On the other hand, excessive or dysregulated TLR3 signaling can lead to chronic inflammation and tissue damage, exacerbating conditions such as autoimmune diseases, chronic viral infections, and cancer. In cancer, TLR3 expression has been linked to both favorable and poor prognoses, though the underlying mechanisms remain unclear. Recent clinical and preclinical advances have explored the use of TLR3 agonists in cancer immunotherapy, attempting to capitalize on their potential to enhance anti-tumor responses. The dual role of TLR3 highlights its complexity as a therapeutic target, necessitating careful modulation to maximize its protective effects while minimizing potential pathological consequences. In this review, we explore the intricate roles of TLR3 in immune responses across different disease contexts, including cancer, infections, autoimmune disorders, and allergies, highlighting both its protective and detrimental effects in these disorders, as well as progress in developing TLR3 agonists as part of the immunotherapy landscape.
Application of virtual planning to maxillofacial reconstruction with an implant prosthesis: a case report
Authors: Oyamada Yutaro , Yamada Hiroyuki , Miyamoto Ikuya , Kondo Hisatomo 
Published: February 2025

Abstract

Background
A case of postoperative mandibular defects was successfully managed using an intraoral scanner and computer-aided design/computer-aided manufacturing (CAD/CAM) technology, facilitating jaw reconstruction and functional restoration with implants for a critical mandibular defect.

Case presentation
The intraoral scanner was used to scan the maxilla and mandible, and occlusal scans were acquired. The obtained data were imported to CAD/CAM software to design the virtual teeth. Digital Imaging and Communications in Medicine data of preoperative cone-beam computed tomography images were converted to three-dimensional (3D) data using specialized software to examine the mandibular bone volume and modify the jawbone morphology. All data were superimposed on the implant simulation software, and jawbone morphology was modified considering the implant placement position. The finalized jawbone 3D data were printed using a 3D printer. Then, a titanium mesh tray was fabricated on the 3D printed model. Subsequently, iliac cancellous bone grafting using a titanium mesh tray and implant treatment were performed.

Conclusions
The application of digital technology helped visualize the final image of the treatment result and collaborate closely with the oral surgeon from the pre-reconstruction stage. This technique allows mandible reconstruction after considering the implant placement based on the ideal prosthesis.
Incorporating community perspective in research funding: creation of the National Multiple Sclerosis Society Community Review of MS Research Committee
Authors: Lampe Anna T. , Zackowski Kathleen M. 
Published: February 2025

Abstract
Integrating community voices in scientific research is important to ensure the research outcomes reflect what is meaningful to that community. However, the process by which individuals from the community are included in scientific grant funding decisions is variable and often comprises only a patient representative on a review panel or advisory board that is largely composed of scientific experts in the field. Finding the right balance for incorporating and honoring the scientific community’s technical expertise and the patient community’s lived expertise has been a growing discussion. The work of the National Multiple Sclerosis (MS) Society is a movement by and for all people affected by MS, meaning that the perspectives of people living with MS (MS community) are essential in all work conducted by the Society. In alignment with this, the National MS Society formed the Community Review of MS Research Committee (Committee) in 2021 to gather feedback from MS community members on research grant applications. The Committee’s feedback focuses on patient-centered concerns and relevance to the MS community. The Committee is composed of a diverse group of non-scientist individuals affected by MS that provide the Society with unique MS community-specific feedback, separate from the established scientific review committee. Here the process of identifying the goals of this Committee and planning of the processes used by the committee, as well as committee implementation, execution, and refinement over three years is described. Through feedback from this Committee, it was demonstrated that people affected by MS have important perspectives and insights into research projects focused on MS and can offer unique guidance to scientist applicants. This Committee has provided benefits to the Society, the MS community, and the Committee members themselves. In addition, the formation of this Committee has allowed the Society to be better informed about topics that are relevant to the MS community and to comprehensively and systematically incorporate the MS community’s perspectives in research grant funding decisions. This publication is intended to share learnings from the development of this Committee to be useful for other disease communities with the goal of incorporating the community voice into scientific research.
Consumer behavior and its role in E. coli outbreaks: the impact of fast-food preparation practices and hygiene awareness
Authors: Ajekiigbe Victor Oluwatomiwa , Ogieuhi Ikponmwosa Jude , Anthony Chidera Stanley , Bakare Ifeoluwa Sandra , Anyacho Sopuruchukwu , Ogunleke Praise Oluwatobi , Fatokun Damilola Ifeoluwa , Akinmeji Olufemi , Ruth Osineye Tolulope , Olaore Akintomiwa Kolawole , Amusa Oluwafemi , Agbo Chinonyelum Emmanuel 
Published: February 2025

Abstract

Background
The fast-food industry, a rapidly expanding business due to the influence of urbanization and busy lifestyles, has significantly shaped consumer food habits and quality food-seeking behavior. However, this fast-growing sector is frequently challenged by bacteria of clinical, microbiological, and economic importance, including Escherichia coli (E. coli). While many strains of E. coli are harmless and support digestion, pathogenic variants such as E. coli O157:H7 are responsible for severe foodborne illnesses, public health crises, and economic losses.

Main body
Our study explores consumer behavior within the fast-food industry, highlighting its role in shaping responses to E. coli outbreaks. Also, it examines how increased awareness of food safety risks has influenced consumer decisions, such as adopting hygienic practices and preferring establishments that prioritize food safety. Furthermore, the study investigates the contribution of poor fast-food preparation practices—such as undercooking and cross-contamination—to the spread of E. coli and emphasizes the critical need for improved hygiene awareness among fast-food workers. We analysed notable case studies involving E. coli outbreaks linked to fast-food chains, and subsequently identified gaps in industry practices and consumer behavior that exacerbate the risk of foodborne illnesses. This emphasizes the importance of preventive measures, including industry-driven reforms such as enhanced food handling protocols and consumer education programs, to mitigate future outbreaks.

Conclusions
This study aims to provide evidence-based insights into the shared responsibility of fast-food establishments and consumers in reducing the prevalence of E. coli infections. By addressing gaps in hygiene awareness and preparation practices, the findings emphasize the potential for collaborative efforts to strengthen public health outcomes and prevent further outbreaks.
Patient reported physical function, mental health, and treatment patterns in dermatomyositis: survey results from a cross-sectional study of adult dermatomyositis patients
Authors: Christopher-Stine Lisa , Paik Julie J. , Goriounova Alexandra S. , Mudd Paul N. 
Published: February 2025

Abstract

Objectives
Dermatomyositis (DM) is a rare and progressive immune-mediated disease with no cure and significant patient burden that encompasses physical, mental, and financial impacts. Patients experience debilitating symptoms that may include muscle weakness, itchy and painful rash, joint pain, and fatigue. Despite the heterogeneity of the disease and the breadth of possible symptoms, the impact of DM on a diverse range of patients’ quality of life (QoL) has not been well-characterized in literature. The aim of this study was to describe the experiences of patients living with DM as they relate to physical and mental impacts, productivity, and treatment patterns and satisfaction.

Methods
To address this deficiency, a 60-question survey was developed to capture adult patient perspectives on the impact of DM on their QoL. Members of The Myositis Association (TMA) with a self-reported diagnosis of DM who were 18–75 years old and whose disease duration was ≥ 1 year were invited to complete the online survey.

Results
Respondents were predominantly female (88%, 172/195), white (82%, 160/195), and had a median age of 57 years. Approximately 50% (98/195) of the respondents rated their overall symptoms as moderate and the three most bothersome symptoms were muscle weakness (44%, 86/195), fatigue (43%, 84/195), and muscle pain (30%, 59/195). Almost all respondents (83%, 162/195) experienced some form of mental stress due to DM and reported that this had a negative impact on interpersonal relationships. The majority (87%, 170/195) of respondents were less than satisfied with the level of support they received for DM.

Conclusions
Our study demonstrates the significant burden of DM on a patients’ QoL and there remains a large unmet need for financial support, mental health care, and improved treatment options for patients living with DM.
A multi-agent approach with verifiable and data-sovereign information flows for decentralizing redispatch in distributed energy systems
Authors: Heess Paula , Holly Stefanie , Körner Marc-Fabian , Nieße Astrid , Radtke Malin , Schick Leo , Stark Sanja , Strüker Jens , Zwede Till 
Published: February 2025

Abstract
The need to harness the flexibility of small-scale assets for system stabilization, including redispatch, is growing rapidly with the increasing prevalence of distributed generation, such as photovoltaic systems and heavy loads, in particular heat pumps and electric vehicles. Integrating these resources into the redispatch process presents special requirements: On the one hand, building trust with the owners of such assets requires privacy and a reasonable degree of autonomy and engagement. On the other hand, besides the system’s scalability and robustness, the verifiability and traceability of provided data are essential for grid operators who depend on the reliable provision of redispatch services. To date, research and practice have encountered significant challenges in defining a system that enables the inclusion of decentralized flexibilities while satisfying necessary requirements. To that end, we present a novel conceptual system design that addresses these challenges by combining a multi-agent system (MAS) approach with verifiable information flows through digital self-sovereign identities (SSIs) and Zero-Knowledge-Proofs (ZKPs). Single agents, as edge devices, operate locally and autonomously, respecting customer preferences, while MAS provide the ability to design robust, reliable, and scalable systems. SSI enables agents to manage their data autonomously, while ZKPs are used to protect users’ privacy through selective data disclosure which allows the verification of the correctness of information without disclosing the underlying data. To validate the feasibility of this design, a case study is included to demonstrate the functionality of key sub-processes, such as baseline optimization, aggregation, and disaggregation, in a realistic scenario. This case study, supported by a prototype implementation, provides initial evidence of the concept’s soundness and lays the groundwork for future evaluation through extensive simulations and field testing. Together, the technologies included in the conceptual system design balance full transparency for grid operators with autonomy and data economy for asset owners.