bluuebunny/crossref_metadata_2025_split huggingface dataset:
(36) DRAINED VERSUS NON-DRAINED INFLATABLE PENILE PROSTHESIS IMPLANTATION: A MULTICENTER PROSPECTIVE NONRANDOMIZED PILOT STUDY
Authors: Prof. Daniar Osmonov , Ahmed Ragheb , Prof. Tim Petry , Dr. Ahmed Eraky , Prof. Carlo Bettocchi , Prof. Glenn Lamers , Prof. Koenraad Van Renterghem , Prof. Marina Tropmann-Frick , Prof. Klaus-Peter Jünemann , Prof. Giulio Garaffa , Prof. Hartmut Porst , Ahmed Mohamed , Prof. Steven Wilson 
Published: July 2023

Abstract

Objectives
Our goal was to understand the risks and benefits of post-inflatable penile prosthesis (IPP) implanation drainage and optimal duration.

Methods
Patients underwent IPP implantation for the first time by four European high volume surgeons. They were divided into 3 groups based on the presence and duration of drainage. Group 1 (n=114) had no drain placed, Group 2 had a drain placed for 24 hours (n=114) and Group 3 had a drain placed for 72 hours (n=117). The presence or absence of postoperative (PO) scrotal hematoma and prosthesis infection were evaluated and compared between the groups via scrotal ultrasound (US) examination carried out 24 hours then 3 and 10 days PO. All patients were followed up postoperatively for a minimum of 80 days.

Results
The exact distribution of hematoma prevalence was greatest on the 3rd PO day with the highest rate in Group 1: (n=13, 11.4%) followed by Group 2: (n=7, 6.1%) and the least in Group 3: (n=1, 0.9%). The patients from Group 3 demonstrated a statistically significant lower incidence of hematoma on the 10th PO day: (n=1, 0.9%) compared to Group 2: (n= 11, 9.6%) and Group 1: (n=8, 7%, p=0.013). However, on the 3rd PO day, there was a statistically significant lower incidence of hematoma in Groups 3 and 2: (1% and 7%, respectively) versus Group 1: (11.4%, p=0.004). Hematoma rates followed the same group order after the first day of surgery: 8.8% (n=10), 5.3% (n=6), and 1.7% (n=2), respectively. (p=0.054). Five patients (4.4%) in Group 1 and four patients (3.5%) in Group 2 developed an IPP associated infection, opposed to only a single patient (0.85%) in Group 3.

Conclusions
Prolonged scrotal drainage for 72 hours after virgin IPP implantation significantly reduces hematoma and infection rates. It is likely that hematoma formation is per se a predisposing factor for IPP infection.

Conflicts of Interest
The authors of no conflict of interest.
(38) THE AM-EDITS: A NEW TOOL FOR EVALUATING THE ARABIC SPEAKING PATIENT AND PARTNER SATISFACTION FOLLOWING PENILE PROSTHESIS IMPLANTATION
Authors: Ahmed Ragheb , Prof. Daniar Osmonov , Dr. Mahmoud Abdallah , Prof. Akram Elmarakby , Prof. Amr Massoud , Dr. Mohammed Emadelidin , Prof. Ahmed Abdelbary 
Published: July 2023

Abstract

Objectives
Our aim was to introduce a validated and culture-adapted Arabic version of the Modified Erectile Dysfunction Inventory of Treatment Satisfaction (M-EDITS) to be coined as the Arabic M-EDITS (AM-EDITS). We utilized it to investigate Arab patient and partner satisfaction after malleable penile prosthesis implantation (MPPI).

Methods
This was a prospective study of 120 patients undergoing MPPI by a single surgeon. We developed a validated Arabic version of the M-EDITS and coined it as the AM-EDITS. Three telephone encounters were conducted for each couple at 1 month, 3 months, and 6 months postoperative (PO). The first encounter covered general patient perioperative experience, from preoperative counseling till early after surgery. The second and third encounters focused on patient and partner satisfaction regarding implant utilization.

Results
Mean ages for the men and their spouses were 54.7±8.4 and 32.9±4.6 years, respectively. Over 82% of the patients showed a decreased level of anxiety after preoperative counseling. 96% of the patients reported a positive experience regarding their early PO days with above half exceeding their expectations. After 3 months, 82.5% of the men were satisfied, describing their erections to be 80% natural. Of the 92.5% satisfied wives at 3 months, 78.5% were highly satisfied. Feeling sexually desirable by their husbands was reported in 93.4%. Opposed to the significant rise in men’s overall satisfaction and AM-EDITS index by 11.6% and 5.2 ± 0.8% (P &lt;0.001), respectively after 6 months PO, partners demonstrated a 12.4% and 5.9 ± 0.8 decline (P &lt;0.001), respectively, compared to the 3 months PO.

Conclusions
The AM-EDITS may expand the global application of the M-EDITS. MPPI represents a good quality of life treatment option for low-income countries. Time has a positive effect on the Arab men’s PO satisfaction, opposed to their partners’. These findings should be considered during perioperative counseling of both parties to ensure sustainable satisfaction.

Conflicts of Interest
The authors have no conflict of interest.
(314) MED3000, A CLINICALLY PROVEN, FAST-ACTING TOPICAL PRODUCT FOR ERECTILE DYSFUNCTION WITH THE PROSPECT OF BEING THE FIRST GLOBALLY AVAILABLE OTC TREATMENT FOR ED
Authors: Dr. David Ralph , Tim Holland , Ken James ,   On behalf of Futura Medical Developments Ltd
Published: July 2023

Abstract

Objectives
To assess the effectiveness, onset of action and safety of MED3000 gel over a 24-week treatment period in male patients clinically diagnosed with ED.

Methods
100 male patients clinically diagnosed with ED were randomised into two treatment groups, 50 to MED3000 and 50 to Tadalafil (5mg) in 11 Investigational sites in USA, Poland Georgia and Bulgaria.

Results
Both Co-Primary end points were achieved (P&lt;0.001) (1) Mean IIEF-EF change from baseline at 24 weeks (2) Minimal clinically important difference (MCID) exceeded at 24 weeks). 61% of MED3000 users exceeded the MCID at 24 weeks The mean IIEF score at weeks 4, 8, 12, 16, 20, 24 was 4.59, 5.20, 5.12, 5.83, 5.57 5.73 Secondary Endpoint 10 minute onset of action FDA agreed standard for achieving a 10 minute onset of action was achieved. A key differentiator from PDEi's Effective in Mild, Moderate and Severe ED MED3000 also delivered a clinically meaningful outcome over 24 weeks in accordance with the Rosen 2, 5 and 7 criteria (Rosen et al 2011)1 in mild, moderate and severe ED subjects Adverse Events (&lt;2 incidences) are detailed in figure 1.

Reference
1 – Rosen RC et al “Minimal clinically important differences in the erectile function domain in the International Index of Erectile Function Scale Eur Urol 2011;60(5):1010-6

Conclusions
MED3000 has been shown to deliver a clinically meaningful response and is fast-acting. It was also shown to be clinically effective in mild, moderate and severe ED. Results were generally consistent with a previously conducted clinical study used for European approval MED3000 was shown to have minimal adverse events. Its “drug-free” formula provides a further margin of safety with no propensity for adverse drug interactions. This profile makes it suitable for OTC use.
FDA filing for marketing authorisation as a De Novo medical device occured in October 2022.

Conflicts of Interest
Professor David Ralph is a consultant to FMD Tim Holland and Ken James are employees of FMD The study was funded by FMD (Not for promotional purposes in the US).
(311) HYALURONIC ACID INJECTION IN LIFELONG PREMATURE EJACULATION
Authors: Prof. Nicola Mondaini , Dr. Gianluca Scarpelli , Dr. Fabio Crocerossa , Dr. Pela Bisatti , Dr. Andrea Abramo , Prof. Francesco Cantiello , Prof. Rocco Damiano , Prof. Antonio Aversa 
Published: July 2023

Abstract

Objectives
The therapeutic management ofPremature long-life ejaculation (PE) ranges from behavioral therapy to pharmacological treatments. Hyaluronic acid (HA) injection into the glans penis is a non-surgical procedure, intended to reduce glans hypersensitivity, improving the Intravaginal Ejaculation Latency Time (IELT). In this pilot study, we tested the effectiveness of a new technique based on a single HA injection into the frenulum of the glans, to improve IELT in a sample of patients affected by PE.

Methods
IELT was evaluated for each couple. We evaluated also International Index Ercectile Function (IIEF) and Premature Ejaculation Diagnostic Tool (PELT). All patients signed the informed consent. 8 mg of hyaluronic acid sodium salt (IBSA), without local anesthesia, were injected with a 27 G needle at the level of the frenulum of prepuce, corresponding to a triangle that we have named MONAVER (abbreviation form inventors, Mondaini-Aversa). After Injection a light compressive dressing was applied to the penis for 24h. All patients completed the VAS SCALE for pain.

Results
We observed a significant increase of the IELT, in 31 males (25-50 years) enroled in the study, after 1 (median 73.3, IQR 66.2-79.9 seconds) and 2 months (66.2, 63.1-73.9) that gradually decreased at 3-months, remaining still significantly higher than at baseline (34.8, 30.9-37.4). PELT and IIEF questionnaires significantly improved compared to baseline in the first two months of follow-up (p &lt; 0.001).

Conclusions
The preliminary results emerging from this pilot study, highlight the effectiveness of this new HA injection approach, although a larger sample and longer follow-up time are needed to standardize the procedure.

Conflicts of Interest
None
(207) ANDROLOGICAL EFFECTS OF SARS-COV-2 INFECTION: A SYSTEMATIC REVIEW AND META-ANALYSIS
Authors: Dr. Walter Vena , Prof. Giovanni Corona , Dr. Alessandro Pizzocaro , Prof. Francesco Pallotti , Prof. Donatella Paoli , Dr. Giulia Rastrelli , Prof. Elisabetta Baldi , Prof. Nicola Cilloni , Dr. Alessandro Brunetti , Prof. Mauro Gacci , Prof. Federico Semeraro , Prof. Andrea Salonia , Prof. Suks Minhas , Prof. Rosario Pivonello , Dr. Alessandra Sforza , Prof. Linda Vignozzi , Prof. Andrea Isidori , Prof. Andrea Lenzi , Prof. Mario Maggi , Prof. Francesco Lombardo 
Published: July 2023

Abstract

Objectives
The short- and long-term andrological effects of coronavirus disease 2019 (COVID-19) have not been clarifed. Our aim is to evaluate the available evidence regarding possible andrological consequences of COVID-19 either on seminal or hormonal parameters. The safety of the COVID-19 vaccines in terms of sperm quality was also investigated.

Methods
All prospective and retrospective observational studies reporting information on severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) mRNA semen and male genitalia tract detection (n=19), as well as those reporting data on semen analysis (n=5) and hormonal parameters (n=11) in infected/recovered patients without any arbitrary restriction were included.

Results
Out of 204 retrieved articles, 35 were considered, including 2092 patients and 1138 controls with a mean age of 44.1±12.6 years, and mean follow-up 24.3±18.9 days. SARS-CoV-2 mRNA can be localized in male genitalia tracts during the acute phase of the disease. COVID-19 can result in short-term impaired sperm and T production. Available data cannot clarify long-term andrological efects. Low T observed in the acute phase of the disease is associated with an increased risk of being admitted to the Intensive Care Unit or death. The two available studies showed that the use of mRNA COVID-19 vaccines does not affect sperm quality.

Conclusions
The results of our analysis clearly suggest that each patient recovering from COVID-19 should be monitored to rule out sperm and T abnormalities. The specifc contribution of reduced T levels during the acute phase of the infection needs to be better clarifed.

Conflicts of Interest
The authors declare that they have no confict of interest.
(26) SEXUALLY TRANSMITTED DESEASES AND ADHD: A SYSTEMATIC LITERATURE REVIEW
Authors: Lorenzo Soldati , Roland Hasler , Pauline Schockaert , Marie-Pierre Deiber , John Köhl , Mylène Bolmont , Prof. Nader Perroud 
Published: July 2023

Abstract

Objectives
Subjects with attention-deficit/hyperactivity disorder (ADHD) suffer from inattention, hyperactivity and impulsivity. Clinicians often assume that the specific difficulties of ADHD are bound to affect sexual behaviours, and favour risky sexual behaviors (RSBs), thereby increasing the frequency of sexually transmitted diseases (STDs). This review is intended to provide an up to date synthesis of the literature surrounding STDs in patients with ADHD.

Methods
A systematic review of the literature was performed using Medline, PsychInfo and Embase databases, with STDs as the main outcome measure.

Results
8 articles were included in the systematic review.
Three studies showed significantly higher frequencies of STDs in ADHD populations and three did not show any significant difference with control. Two studies showed a signifiantly lower age at first STD contraction. Two studies showed that use of ADHD medication was related to a lower risk of subsequent STD.

Conclusions
This is the first systematic review of STDs in individuals with ADHD, suggesting that subjects with ADHD report more STDs than the general population.
Some authors hypothesized that these results could be explained by impulsivity, hyperactivity and inattention of ADHD, but also emphasized the role of psychiatric comorbidities, especially substance use disorders.
The results of this review lead us to recommend that psychiatrists treating ADHD make their patients aware of the risk of STDs and that better compliance with medication is a protective factor for STDs.
Results are limited by the small number of existing studies as well as the heterogeneity of the outcome measures. Further studies are warranted to better evaluate the risk of contracting a STD in subjects with ADHD.

Conflicts of Interest
The authors have no conflict of interest to declare.
(195) IS THE STRETCH FLACCID PENILE LENGTH (SFPL) COMPARABLE WITH ERECT PENILE LENGTH (EPL)?
Authors: Dr. Manuel Alonso-Isa , Dr. Borja García-Gómez , Dr. Guillermo Celada-Luis , Dr. Alessandro Fiorillo , Dr. Daniel Tueti-Silva , Dr. Esther García-Rojo , Eduard García-Cruz , Javier Romero-Otero 
Published: July 2023

Abstract

Objectives
SFPL is the length that a non-erect penis can be comfortably extended to. It has been suggested that SFPL is an excellent surrogate for erect penile length EPL. We aimed to evaluate if the SFPL accurately reflects EPL.

Methods
We retrospectively review a total of 225 patients from February 2021 to October 2022 who underwent penile ultrasonography with prostaglandin injection (10 mcg). Demographic, vascular and other relevant variables were recorded for analysis. A history of Peyronie disease or penile surgery (excluding postectomy and frenuloplasty) were exclusion criteria. After injecting prostaglandin, measures of the penis were taken (in cm) and only grade 3 of Erection Hardness Score (EHS 3) and 4 (EHS 4) were included.
Three different urologists did all the measurements using a caliper, which was placed along the dorsal side of the penis, extending from the pubo-penile skin junction to the tip of the glans where the pre-pubic fat pad was pushed to the bone.

Results
Mean age 48 (range 17-98). Mean penis size (flaccid) 10.07cm (range 4-17). Mean SFPL 15.32 (range 10.4-19.7). Mean EPL 14.37 (range 9.0-19.5). Mean SFPL (EHS 3) 15.30 (range 10.4-19.6). Mean SFPL (EHS 4) 15.37 (range 11.4-19.7). Mean EPL (EHS 3) 14.05 (range 9.0-19.5). Mean EPL (EHS 4) 14.76 (range 11.0-19.0).
Pearson’s correlation coefficient between SFPL and EPL (EHS 3 and 4): r = 0.646
Pearson’s correlation coefficient between SFPL and EPL (EHS 3): r = 0.530
Pearson’s correlation coefficient between SFPL and EPL (EHS 4): r = 0.574

Conclusions
A correlation between SFPL and erect EPL has been found. We can consider SFPL a fairly approximate measure in most cases of EPL.

Conflicts of Interest
Authors have no potential conflict of interest to report.
(279) THE ROLE OF TESTOSTERONE TREATMENT IN PATIENTS WITH METABOLIC SYNDROME: RESULTS FROM A META-ANALYSIS STUDY
Authors: Dr. Walter Vena , Dr. Nicola Bianchi , Dr. Francesca Frizza , Dr. Francesca Briganti , Prof. Giulia Rastrelli , Prof. Linda Vignozzi , Prof. Arcangelo Barbonetti , Dr. Alessandro Pizzocaro , Dr. Alessandro Brunetti , Prof. Edoardo Mannucci , Dr. Alessandra Sforza , Prof. Mario Maggi , Dr. Giovanni Corona 
Published: July 2023

Abstract

Objectives
Metabolic syndrome (MetS) is often associated with male hypogonadism. Despite the well-known link, the role of testosterone [T] replacement therapy [TRT] on glycometabolic profile and body composition, in patients with metabolic syndrome [MetS], is still conflicting and argue of large scientific debate. The aim of the present study is to meta-analyze the role of TRT in MetS considering all placebo and non-placebo-controlled randomized clinical trials [RCTs].

Methods
An extensive Medline search was performed including the following words “testosterone”, “metabolic syndrome” and “males”. No search software was used, but we hand-searched bibliographies of retrieved papers for additional references.

Results
Overall, 7 studies were available including 576 patients with a mean follow-up of 48.9 weeks. These trials differ in basal TT levels and type of T preparation used. In addition, only 6 were placebo controlled. TRT resulted to significantly improve waist circumferece, fasting glycemia, A1c serum levels, HOMA-Indes and serum tryglycerides (p &lt; 0.001) when all studies were considered, however this difference was not significant when only placebo-controlled studies were considered, except for waist circumference (p= 0.05). When only placebo/controlled RCT were considered, TRT resulted to significantly improve body fat mass (p= 0.04).

Conclusions
TRT was able to significantly decrease fasting glycaemia, glycosylated hemoglobin, HOMA-IR index, triglyceride levels, fat mass and waist circumference. In contrast, we did not observe any significant effect on total or HDL cholesterol, blood pressure and BMI. When considering only placebo-controlled studies, only differences of HbA1c, HOMA-IR index, triglyceride levels, fat mass and waist circumference retained statistical significance, but not fasting glycaemia, although a trend was apparent.

Conflicts of Interest
No conflict of interest to declare.
(107) CAN AGEISM RELATED TO ELDERLY PEOPLE AND DYSFUNCTIONAL BELIEFS ABOUT SEXUALITY OF ELDERLY PEOPLE BE ASSOCIATED WITH SEXUAL ACTIVITY AND SEXUAL LIFE? A COMPARISON BETWEEN HETEROSEXUAL AND HOMOSEXUAL MEN AND WOMEN
Authors: Dr. Erika Limoncin , Dr. Luca Flesia , Dr. Elena Colonnello , Dr. Daniele Mollaioli , Dr. Andrea Sansone , Prof. Giacomo Ciocca , Prof. Emmanuele Angelo Jannini 
Published: July 2023

Abstract

Objectives
No information exists about the impact of ageism and dysfunctional beliefs on quality of sexual life of elderly people, considering several sexual orientations. Aim of this study was to evaluate: (1) the presence of “ageism” in elderly heterosexual and homosexual persons (2) the impact of ageism on sexual activity/sexual satisfaction of elderly heterosexual and homosexual persons (3) the impact of dysfunctional beliefs about elderly people on sexual activity/sexual satisfaction.

Methods
Elderly people were evaluated cross-sectionally through an online survey managed using GoogleForms. To enrol elderly heterosexual and homosexual people, the link was then disseminated to LGB communities and social media. Evaluation of demographics, of physical and psycho-social wellbeing, of the ageism and of dysfunctional beliefs was made with an explorative questionnaire.

Results
The results showed no statistically significant difference between homosexuals and heterosexuals in terms of the presence of ageism related to old age (p=0,47). On the contrary, homosexuals perceive significantly less the social representation of sexuality of elderly people in respect to heterosexual ones (p=0,0007). Dysfunctional beliefs about sexuality of elderly people are significantly more present among heterosexual people (p=0,0001). In terms of sexual behaviour, elderly homosexual people declared significantly higher frequency of sexual activities (p&lt;0,05), compared to that referred by heterosexual persons.

Conclusions
In line with these findings, it is possible to suppose that ageism related to sexuality, expressed as the absence of social representation of sexuality in elderly people, is more present in homosexuals, while dysfunctional beliefs about sexuality could impact more on sexuality of heterosexual people.

Conflicts of Interest
All the authors declared no conflict of interests. Prof. Jannini Emmanuele declared to have or have been speaker/paid consultant for: Bayer, Ibsa, Lundbeck, Menarini, Otsuka, Pfzer, Shionogi, and Viatris.
(234) THE PARAPHILE PROJECT: AN OVERVIEW OF EDUCATIONAL ACTIVITIES AND THEIR OUTCOMES IN THE TARGET GROUP OF POLICE OFFICERS
Authors: Leona Plášilová , Kateřina Potyszová , Marek Navrátil , Kateřina Klapilová 
Published: July 2023

Abstract

Objectives
The Paraphile project is a pilot project that started in 2019 in the Czech Republic at the National Institute of Mental Health. It has established a system of early interventions for people in increased risk of sexual offending on-line and off-line, namely for individuals with paraphilic sexual preferences (and their close persons). The project offers free and anonymous long-term psychotherapy led by trained professionals (psychologists, psychiatrists, sexologists). The project also disseminates its know-how among the general and professional public. Within the professional community, it targets police officers, social workers and health professionals who attend four-hour training course. Workshop topics include an introduction to paraphilia theory, an introduction to the system of care, the differences between deviance and delinquency, risk and protective factors for paraphilias, recidivism, and sexuality in cyberspace. Between 2021 and 2022, 75 police officers were trained by the Parafilik project and the effectiveness of this course for this target group was evaluated.

Methods
This paper will present preliminary data on the effectiveness of the project's training course for the target group of police officers, including measurements of specific variables before and after the training course. The variables include: professional competence to intervene toward a client with paraphilia, stigma, and emotional compliance. The evaluation also includes a qualitative summary of outcomes.

Results
The results are currently being analyzed and will be presented at the conference.

Conclusions
The results will contribute to the understanding of the training needs of police officers on the topic of paraphilias, including an evaluation of the training courses conducted and their effectiveness. This knowledge can be further used in future planning of educational activities on paraphilias and other sexological topics for the target group of police officers.

Conflicts of Interest
The authors declare that there is no conflict of interest.