bluuebunny/crossref_metadata_2025_split huggingface dataset:
Parental knowledge and communication with their adolescent on sexual and reproductive health issues in Nepal
Authors: Singh Devendra Raj , Shrestha Shreesha , Karki Kshitij , Sunuwar Dev Ram , Khadka Dan Bahadur , Maharjan Dikshya , Sah Lalita Kumari , Simkhada Bibha , Sah Rajeeb Kumar 
Published: July 2023

Background
Parental knowledge about sexual and reproductive health issues and adequate communication with their adolescent on these issues are crucial in promoting adolescent sexual and reproductive health. Although there are evidence on adolescent perceptions of their sexual health issues, research on parental perspectives of adolescent sexual health and parent-adolescent communication about sexual health issues in Nepal remains unexplored. Therefore, this study aimed to assess parental knowledge and communication practice about sexual and reproductive health with their adolescent children in Lalitpur Metropolitan City of Nepal.

Methods
A community-based cross-sectional study was conducted between January and March 2019 among randomly selected 308 parents of adolescents (aged 10–19 years) residing in Lalitpur Metropolitan City of Nepal. Face-to-face interviews using structured questionnaires were conducted to collect the data. The collected data were entered into EpiData software v3.1, and data analysis was performed using IBM SPSS Statistics for Windows Version 21.0 (IBM Corp. Armonk, NY, USA). The statistical significance was considered at a p-value <0.05 and a 95% confidence interval (CI).

Results
Of 308 parents, one-third of parents were found to have correct knowledge about safe abortion, menstrual hygiene and management, modern contraceptives, prevention of sexually transmitted infections, wet dreams among male adolescents, abstaining from sexual intercourse during the fertile period, and the possibility of a male adolescent to impregnate a girl. In addition, only 40.9% of parents were found to have communicated with their adolescent children about sexual and reproductive health issues. Parents who have knowledge about puberty (aOR = 2.2, 95% CI: 1.2–3.9), belong to Bharamin/Chhetri ethnic group (aOR = 1.2, 95% CI: 1.1–2.2), self-employed (aOR: 2.4, 95% CI: 1.3–4.0), having two or more adolescent children (aOR = 2.0, 95% CI: 1.1–3.6), and whose adolescent children were staying in school hostel (aOR = 1.7, 95% CI:1.0–3.0) were more likely to have parental communication about sexual and reproductive health with their adolescent children.

Conclusions
Most parents do not communicate with their adolescent children on sexual health topics, although they feel sexual health education is essential to adolescents. The majority of parents were found inadequately aware of adolescent sexual health issues. It is crucial to have contextual interventions that would encourage parent-adolescent communication on sexual health matters in an integrated way to promote adolescent sexual and reproductive health.
Precise registration of axonal morphologies obtained from sections to a common reference space
Authors: Piastra Maria Carla , Bakker Rembrandt , Garcia-Amado Maria , Rubio-Teves Mario , Clascá Francisco , Tiesinga Paul 
Published: July 2023

We present a strategy to register manually traced neuronal morphologies to a reference atlas, with the final goal to publish the aligned neurons in the EBRAINS knowledge-graph, visualize them in the interactive atlas viewer and compare them to other published neurons.
Our use case consists of a thalamo-cortical long-range projection neuron that is manually traced from 33 sagittal tissue sections of a mouse brain. We apply a three-step procedure:1. Manually select for each tissue section a corresponding slice from a reference atlas.2. Deform each tissue section such that its outline and anatomical features match that of the corresponding reference slice.3. For each section, apply the same deformation to the portion of the neuron that it intersects.
A trained neuroanatomist confirmed the correct thalamic and cortical positioning of the neuron. In terms of the alignment of the neuron with respect to cortical layers, we found up to 50% discrepancies. A procedure was developed to shift the cortical depth of the neuron and reduce the error to below 10%.
Maternal vitamin A status as a risk factor for Hirschsprung Disease in the child
Authors: Hegde Shalini G , Devi Sarita , Sivadas Ambily , Shubha Attibele Mahadevaiah , Thomas Annamma , Mukhopadhyay Arpita , Kurpad Anura V 
Published: July 2023

ABSTRACT

Background and Aims:
The gene-environment interaction of the RET gene with vitamin A in the etiopathogenesis of Hirschsprung disease (HSCR) has been suggested in rodents. The aim of this study was to evaluate vitamin A status in mothers of children with HSCR and to assess its association with pathogenic variants of the RET gene in affected children.

Methods:
Case-control study of stable-isotope based vitamin A measurement stores of mothers of children diagnosed with HSCR (within 8 months from birth, n=7) and age-matched mothers of normal children (n=6). Next-generation sequencing of RET exons, along with their upstream promoter region, was performed in the 7 HSCR proband-parent triads to evaluate pathogenic variants.

Results:
Maternal vitamin A stores in the HSCR group was almost 50% that of controls, tending towards significance (0.50 ± 0.17 versus 0.89 ± 0.51 µmol/g respectively, P=0.079). Two novel pathogenic de novo mutations were identified in two cases, and a rare single nucleotide deletion was detected in the 3.5kb RET upstream region, in a heterozygous state, in all 7 proband-parent triads. Low penetrance RET haplotypes associated with HSCR were detected in 5 cases.

Conclusion:
Mothers with HSCR children had lower vitamin A liver stores than mothers with normal children and the children who were affected had HSCR despite having no established pathogenic RET variants. Lower maternal vitamin A status may increase the penetrance of genetic mutations in RET, and vitamin-A mediated gene-environment interactions may underpin some of the aetiology of HSCR.
Correlation between Periotest value and implant stability quotient: a systematic review
Authors: Semenzin Rodrigues Alana , de Moraes Melo Neto Clóvis Lamartine , Santos Januzzi Marcella , dos Santos Daniela Micheline , Goiato Marcelo Coelho 
Published: July 2023

Abstract

Objectives
To determine, through clinical studies, whether there is a correlation between the Periotest value (PTV) and the implant stability quotient (ISQ).

Content
Methods to evaluate the stability of dental implants.

Summary
A search was performed in the PubMed, Scopus, and Web of Science databases for articles on the proposed subject up to January 29, 2023, using search terms that combined “resonance frequency analysis” and “Periotest” with “correlation” or “relationship”; and combinations of “implant stability quotient” and “Periotest” with “correlation” or “relationship.” The inclusion criteria were clinical studies in English involving human subjects who received dental implants and evaluating the correlation between PTV and ISQ. A total of 46 articles were screened, of which 10 were selected for full-text analysis, and eight articles were included in this review. Based on three articles, 75 % of the results of this systematic review showed a negative correlation between PTV and ISQ, regardless of the type of stability assessed. Based on the remaining five articles, 100 % (regardless of the patient's gender) and 66.66 % of the results showed a negative correlation for primary and secondary stability, respectively. There is a negative correlation between PTV and ISQ for both primary and secondary dental implant stability.

Outlook
This review can serve as a reference for the development of methodologies for future clinical studies on this topic.
On the arithmetic of polynomial semidomains
Authors: Gotti Felix , Polo Harold 
Published: July 2023

Abstract
A subset S of an integral domain R is called a semidomain provided that the pairs

(
S
,
+
)

{(S,+)}

and

(
S
,
⋅
)

{(S,\cdot\,)}

are semigroups with identities. The study of factorizations in integral domains was initiated by Anderson, Anderson, and Zafrullah in 1990, and this area has been systematically investigated since then. In this paper, we study the divisibility and arithmetic of factorizations in the more general context of semidomains. We are specially concerned with the ascent of the most standard divisibility and factorization properties from a semidomain to its semidomain of (Laurent) polynomials. As in the case of integral domains, here we prove that the properties of satisfying the ascending chain condition on principal ideals, having bounded factorizations, and having finite factorizations ascend in the class of semidomains. We also consider the ascent of the property of being atomic and that of having unique factorization (none of them ascends in general). Throughout the paper, we provide several examples aiming to shed some light upon the arithmetic of factorizations of semidomains.
Restriction estimates in a conical singular space: Schrödinger equation
Authors: Chen Jingdan , Gao Xiaofen , Xu Chengbin 
Published: July 2023

Abstract
This paper continues our previous program to study the restriction estimates in a class of conical singular spaces

X
=

C
⁢

(
Y
)

=

(
0
,
∞
)

r

×
Y

{X=C(Y)=(0,\infty)_{r}\times Y}

equipped with the metric

g
=

d
⁢

r
2

+

r
2

⁢
h

{g=\mathrm{d}r^{2}+r^{2}h}

, where the cross section Y is a compact

(

n
-
1

)

{(n-1)}

-dimensional closed Riemannian manifold

(
Y
,
h
)

{(Y,h)}

. Assuming the initial data possesses additional regularity in the angular variable

θ
∈
Y

{\theta\in Y}

, we prove some linear restriction estimates for the solutions of Schrödinger equations on the cone X.
The smallest positive eigenvalue of the operator

Δ
h

+

V
0

+

(

n
-
2

)

2

/
4

{\Delta_{h}+V_{0}+(n-2)^{2}/4}

plays an important role in the result. As applications, we prove local energy estimates and Keel–Smith–Sogge estimates for the Schrödinger equation in this setting.
Fractional integrals associated with Radon transforms
Authors: Rubin Boris 
Published: July 2023

Abstract
We obtain sharp

L
p

{L^{p}}

-

L
q

{L^{q}}

estimates for fractional integrals generated by Radon transforms of the following three types: The classical Radon transform over the set of all hyperplanes in

ℝ
n

{\mathbb{R}^{n}}

,
the Strichartz transversal transform over only those hyperplanes which meet the last coordinate axis, and the Radon transform associated with paraboloids. The method relies on a version of Stein’s interpolation theorem for analytic families of operators communicated by L. Grafakos.
Anti-inflammatory effect of ApoE23 on Salmonella typhimurium-induced sepsis in mice
Authors: Wang Chuanqing , Yin Lijun , Fu Pan , Lu Guoping , Zhai Xiaowen , Yang Changsheng 
Published: July 2023

Abstract
Two independent experiments were performed with three groups each (sepsis control, sepsis, and sepsis with apoE23 treatment) to investigate the anti-inflammatory effect of apolipoprotein 23 (apoE23) in a mouse model of sepsis induced by S. typhimurium. Survival rates; plasma level variations in tumor necrosis factor (TNF)-α, interleukin (IL)-6, and lipopolysaccharide (LPS); S. typhimurium colony-forming units in the spleen tissue; and mRNA and protein expression levels of low-density lipoprotein receptor (LDLR), LDLR-related protein (LRP), syndecan-1, and scavenger receptor B1 were evaluated in the livers of mice from the three groups. Results found that the survival rate of septic mice treated with apoE23 was 100% within 48 h, while it was only 40% in septic mice without apoE23 treatment (P < 0.001). The plasma LPS, TNF-α, and IL-6 levels and the S. typhimurium load in mice in the apoE23-treated group were significantly lower than those in septic mice (P < 0.05). Moreover, apoE23 restored the downregulated expression of LDLR and LRP in the liver tissue of septic mice. So apoE23 exhibits an anti-inflammatory effect in the mouse model of S. typhimurium-induced sepsis. Further studies are required to understand the mechanisms underlying the anti-inflammatory effects of apoE23.
Two novel lead(ii) coordination complexes incorporating phenanthroline derivate: Synthesis and characterization
Authors: Feng Jingdong , Li Ziru , Wang Xiuyan 
Published: July 2023

Abstract
Two lead(ii) coordination complexes with 2-(4-fluoro-phenyl)-1H-imidazo[4,5-f][1,10]phenanthroline formulated as [Pb(L)2(tlba)2)] (1) and [Pb(L)(dpea)]2 (2) (HTLBA = 2,3,4,5-tetrachlorobenzoic acid, H2dpea = diphenic acid) were synthesized under hydrothermal conditions. In 1, the neighboring [Pb(L)2(tlba)2)] molecules formed into a two-dimensional (2D) layer structure with C–Cl⋯π interactions and N–H⋯O hydrogen bond interactions. For 2, Pb1 and Pb1i ions are connected by four carboxylate groups from two dpea anions to yield a binuclear unit. Two L ligands are situated in two flanks of the dimer. The L ligands from dimers in the vicinity pile up by two π–π interactions to form a 2D supramolecular structure. Moreover, PXRD of 2 was also studied.
Human stem cell modeling of neuropsychiatric disorders: from polygenicity to convergence
Authors: Duan Jubao 
Published: July 2023

Abstract
Neuropsychiatric disorders (NPD) are prevalent and devastating, posing an enormous socioeconomic burden to modern society. Recent genetic studies of NPD have identified a plethora of common genetic risk variants with small effect sizes and rare risk variants of high penetrance. While exciting, there is a pressing need to translate these genetic discoveries into better understanding of disease biology and more tailored clinical interventions. Human induced pluripotent stem cell (hiPSC)-derived 2D and 3D neural cultures are becoming a promising cellular model for bridging the gap between genetic findings and disease biology for NPD. Leveraging the accessibility of patient biospecimen to convert into stem cells and the power of genome editing technology to engineer disease risk variants, hiPSC model holds the promise to disentangle the disease polygenicity, model genetic interaction with environmental factors, and uncover convergent gene pathways that may be targeted for more tailored clinical intervention.
Involvement of microglia in chronic neuropathic pain associated with spinal cord injury – a systematic review
Authors: Ramos David , Cruz Célia Duarte 
Published: July 2023

Abstract
In recent decade microglia have been found to have a central role in the development of chronic neuropathic pain after injury to the peripheral nervous system. It is widely accepted that peripheral nerve injury triggers microglial activation in the spinal cord, which contributes to heightened pain sensation and eventually chronic pain states. The contribution of microglia to chronic pain arising after injury to the central nervous system, such as spinal cord injury (SCI), has been less studied, but there is evidence supporting microglial contribution to central neuropathic pain. In this systematic review, we focused on post-SCI microglial activation and how it is linked to emergence and maintenance of chronic neuropathic pain arising after SCI. We found that the number of studies using animal SCI models addressing microglial activity is still small, compared with the ones using peripheral nerve injury models. We have collected 20 studies for full inclusion in this review. Many mechanisms and cellular interactions are yet to be fully understood, although several studies report an increase of density and activity of microglia in the spinal cord, both in the vicinity of the injury and in the spared spinal tissue, as well as in the brain. Changes in microglial activity come with several molecular changes, including expression of receptors and activation of signalling pathways. As with peripheral neuropathic pain, microglia seem to be important players and might become a therapeutic target in the future.
La imagen antiepidémica de China en el Perú desde la perspectiva del análisis crítico del discurso
Authors: Liu Peng 
Published: July 2023

Resumen
El presente trabajo analiza los reportajes publicados entre febrero y agosto de 2020 en dos periódicos del Perú en torno a la pandemia del nuevo coronavirus relacionados con China. Empleando el método de base de datos y la Teoría de Evaluación, se disecciona la actitud y la posición detrás de los titulares de dichas informaciones, descifrando la imagen de China a ojos de los medios de comunicación peruanos, y se revelan las relaciones reales entre China y el Perú, así como la ideología peruana subyacente a sus discursos. Este estudio descubre que los reportajes se basan en una actitud predominantemente positiva y que presentan a China con la imagen de una gran nación con alto nivel de gobernanza, con poderío científico y tecnológico y responsabilidad en diversos temas, lo que valida una posición del Perú basada en sus propios intereses reales de desarrollo. La actitud negativa en lo relativo al debate sobre el origen de la epidemia del coronavirus refleja la opción estratégica del Perú de “entre dos aguas” ante el regreso a la “Doctrina Monroe” de la Administración de Trump impuesta en la región latinoamericana por Estados Unidos.
(Ca0.95Cd0.10)Pd2Cd3, SrPd2Cd3 and (Eu0.95Cd0.10)Pd2Cd3 with YNi2Al3 type structure – crystal chemistry and magnetic hyperfine interactions
Authors: Johnscher Michael , Gerke Birgit , Kösters Jutta , Block Theresa , Niehaus Oliver , Reimann Maximilian Kai , Pöttgen Rainer 
Published: July 2023

Abstract
The intermetallic compounds (Ca0.95Cd0.10)Pd2Cd3, SrPd2Cd3 and (Eu0.95Cd0.10)Pd2Cd3 were synthesized from the elements in sealed niobium ampoules in an induction furnace. The polycrystalline samples were characterized through their Guinier powder patterns. The structures were refined from single crystal X-ray diffractometer data: YNi2Al3 type, P6/mmm, a = 984.61(5), c = 455.33(3) pm, wR2 = 0.0216, 376 F
2 values, 21 variables for (Ca0.95Cd0.10)Pd2Cd3, a = 998.55(8), c = 453.65(3) pm, wR2 = 0.0296, 341 F
2 values, 17 variables for SrPd2Cd3 and a = 992.57(4), c = 457.34(2) pm, wR2 = 0.0300, 384 F
2 values, 21 variables for (Eu0.95Cd0.10)Pd2Cd3. The striking crystal chemical motif in the three structures is a planar [PdCd2] Kagome-type layer. The two crystallographically independent Ca (Sr, Eu) atoms have a coordination number of 18 by 6 Pd and 12 Cd atoms. The calcium and europium compound show a small degree of Ca (Eu) substitution by Cd2 dumb-bells with 281 pm Cd–Cd in (Eu0.95Cd0.10)Pd2Cd3. Temperature dependent magnetic susceptibility measurements show Curie–Weiss behaviour (7.63(1) µB/Eu atom) for the europium compound and the onset of ferromagnetic ordering at T
C = 14.9(2) K. The divalent character of europium is corroborated by 151Eu Mössbauer spectroscpy.
Aristotelismo y ciencia moderna en la Nueva España. El De philosophiae vicissitudinibus del jesuita guanajuatense Andrés de Guevara y Basoazábal
Authors: González Nares Gabriel , Meza Mejía Mónica del Carmen 
Published: July 2023

Andrés de Guevara y Basoazábal (1748-1801), jesuita novohispano guanajuatense, escribió las Institutionum elementarium philosophiae, donde su autor ofrece un currículo deseable para la juventud mexicana que incluya la ciencia moderna empírica, la política virtuosa y la sabiduría humana. A través de una traducción comparativa del latín al español del proemio de la citada obra, este artículo pretende: 1) contextualizar al autor novohispano, 2) mostrar la recepción de la ciencia moderna desde los elementos aristotélicos de los que Guevara dispuso, y 3) mostrar que la modernidad y la tradición aristotélica se enriquecieron mutuamente; y lo que debía de reformarse era la escolástica anquilosada. Se concluye que a través del proemio De vicissitundinibus de Guevara se evidencia la recepción mexicana de la modernidad emanada de una mentalidad aristotélica.
Crónica à clef. Reseña a Estrella de dos puntas de Malva Flores
Authors: Pérez Sánchez Luis Felipe 
Published: July 2023

"Crónica à clef" es fruto de la lectura a Estrella de dos puntas (Ariel, 2021), libro reconocido con el Premio Xavier Villaurrutia, que presenta una disertación basada en la investigación epistolar entre Carlos Fuentes y Octavio Paz. Gracias al seguimiento, Malva Flores propone algunas conclusiones que generarán un debate en la discusión sobre el campo cultural en México.
Effective Utilization of Solar Energy for the Production of Green Hydrogen from Photovoltaic Powered Electrolyzer
Authors: Naqvi Asad A. , Nadeem Talha Bin , Ahmed Ahsan , Butt Faaz Ahmed 
Published: July 2023

Abstract
Hydrogen is considered as the fuel of the future. But currently, efficient, clean, and cheap hydrogen production is one of the challenging tasks. In this article, a clean and cheap hydrogen gas is produced through an alkaline-based water electrolyzer powered by a photovoltaic (PV) module, 27-wt. % sodium hydroxide is used as an electrolyte, and the electrolyzer is constructed by using stainless steel anode and nickel-platted stainless-steel cathode. The radiation on a PV module and current from the PV module is measured, and it is found that maximum radiation and current is possible in May. The ideal volume of hydrogen gas is calculated using Faraday’s, and the actual volume produced is also measured. It is found that the volume of hydrogen gas produced is dependent on the solar flux available. The maximum amount of 100 L of hydrogen gas produced is found to be in May, whereas the minimum is witnessed in August. The effectiveness of hydrogen gas is also calculated to determine the losses in the electrolyzer. The electrolyzer is found to be 15 % effective. Future directions of the research are also provided to improve the effectiveness of the electrolyzer.
Tau and Amyloid β Protein in Patient-Derived Aqueous Brain Extracts Act Concomitantly to Disrupt Long-Term Potentiationin Vivo
Authors: Ondrejcak Tomas , Klyubin Igor , Hu Neng-Wei , O'Malley Tiernan T. , Corbett Grant T. , Winters Róisín , Perkinton Michael S. , Billinton Andy , Prenderville Jack A. , Walsh Dominic M. , Rowan Michael J. 
Published: July 2023

Amyloid β protein (Aβ) and tau, the two main proteins implicated in causing Alzheimer's disease (AD), are posited to trigger synaptic dysfunction long before significant synaptic loss occurs in vulnerable circuits. Whereas soluble Aβ aggregates from AD brain are well recognized potent synaptotoxins, less is known about the synaptotoxicity of soluble tau from AD or other tauopathy patient brains. Minimally manipulated patient-derived aqueous brain extracts contain the more diffusible native forms of these proteins. Here, we explore how intracerebral injection of Aβ and tau present in such aqueous extracts of patient brain contribute to disruption of synaptic plasticity in the CA1 area of the male rat hippocampus. Aqueous extracts of certain AD brains acutely inhibited long-term potentiation (LTP) of synaptic transmission in a manner that required both Aβ and tau. Tau-containing aqueous extracts of a brain from a patient with Pick's disease (PiD) also impaired LTP, and diffusible tau from either AD or PiD brain lowered the threshold for AD brain Aβ to inhibit LTP. Remarkably, the disruption of LTP persisted for at least 2 weeks after a single injection. These findings support a critical role for diffusible tau in causing rapid onset, persistent synaptic plasticity deficits, and promoting Aβ-mediated synaptic dysfunction.SIGNIFICANCE STATEMENTThe microtubule-associated protein tau forms relatively insoluble fibrillar deposits in the brains of people with neurodegenerative diseases including Alzheimer's and Pick's diseases. More soluble aggregates of disease-associated tau may diffuse between cells and could cause damage to synapses in vulnerable circuits. We prepared aqueous extracts of diseased cerebral cortex and tested their ability to interfere with synaptic function in the brains of live rats. Tau in these extracts rapidly and persistently disrupted synaptic plasticity and facilitated impairments caused by amyloid β protein, the other major pathologic protein in Alzheimer's disease. These findings show that certain diffusible forms of tau can mediate synaptic dysfunction and may be a target for therapy.