bluuebunny/crossref_metadata_2025_split huggingface dataset:
FlASHback—personal highlights regarding myelodysplastic syndrome from the 2022 ASH meeting
Authors: Petzer Verena , Wolf Dominik 
Published: August 2023

SummaryThis article intends to summarize and comment on some of the highlights regarding myelodysplastic syndrome (MDS) presented at the 2022 American Society of Hematology (ASH) annual meeting. Many abstracts dealt with the validation of the two new classifications and the International Prognostic Scoring System–Molecular (IPSS-M) being among the most intensively discussed topics in the community. Moreover, for the first time, real-world data on luspatercept were presented. Long-term data from the MEDALIST trial showed which patients benefit most from therapy with luspatercept, adding important information for the use of this substance. However, except for the phase III trial Sintra-REV, practice-changing clinical reports were sparse, although earlier trials in both higher-and lower-risk MDS reported on promising agents currently in clinical development that will hopefully improve the future management of MDS patients.
Pyrotechnology and lipid biomarker variability in pine tar production
Authors: Davara Javier , Jambrina-Enríquez Margarita , Rodríguez de Vera Caterina , Herrera-Herrera Antonio V. , Mallol Carolina 
Published: August 2023

AbstractTar or pitch produced from pine resin and wood played an important role in the past as an adhesive, waterproofing and medicinal product. However, the formation and biomolecular composition of pine tar produced only from resin under different combustion conditions (i.e., temperature and oxygen availability during heating) has not been as widely investigated as pine tar produced by dry distillation of wood or birch bark tar, for which an extensive literature is available. This lack of information hampers technological interpretations of biomolecular data obtained from organic residue analyses of archaeological pine tar products. In this study, we performed controlled laboratory heating sequences with pine resin (Pinus canariensis) at 150, 250, 350 and 450 ºC under both oxygenated and oxygen-limited conditions, and analyzed the products using gas chromatography-mass spectrometry (GC-MS). A control unheated resin sample was also analysed. We found that the formation of pine tar from resin occurs around 250–350 ºC under both oxygenated and oxygen-limited atmospheres. We also present and discuss the lipid biomarkers of pine resin and its combustion products according to changes in temperature and oxygen availability. Our reference data provide new information for the biomolecular identification of archaeological pine tar products and show potential for shedding light on the conditions in which tar was manufactured by ancient populations in different contexts.
Elucidating the Mechanisms of Cell-to-Cell Crosstalk in Probiotics Co-culture: A Proteomics Study of Limosilactobacillus reuteri ZJ625 and Ligilactobacillus salivarius ZJ614
Authors: Kwoji Iliya Dauda , Aiyegoro Olayinka Ayobami , Okpeku Moses , Adeleke Matthew Adekunle 
Published: August 2023

AbstractLimosilactobacillus reuteri ZJ625 and Ligilactobacillus salivarius ZJ614 are potential probiotic bacteria with improved benefits when administered to the host as a multi-strain preparation. To elucidate the mechanisms of cell-to-cell crosstalk between these two strains, we studied their intracellular and extracellular proteomes in co-culture by liquid-chromatography mass-spectrometry (LC-MS) using Dionex Nano-RSLC and fusion mass spectrometer. The experiment consisted of five biological replicates, and samples were collected during the mid-exponential growth phase. The quantitative proteomic profiles revealed several differentially expressed proteins (DEPs), which are down- or up-regulated between and within groups for both the intracellular and extracellular proteomes. These DEPs include proteins synthesising autoinducer-2, a sensor compound for cell-to-cell bacterial crosstalk during quorum sensing in mixed culture. Other important DEPs identified include enolase, phosphoglycerate kinase, and l-lactate dehydrogenase, which play roles in carbohydrate metabolism. Proteins associated with transcription, ATP production and transport across the membrane, DNA repair, and those with the potential to bind to the host epithelium were also identified. The post-translational modifications associated with the proteins include oxidation, deamidation, and ammonia loss. Importantly, this study revealed a significant expression of S-ribosylhomocysteine lyase (luxS) involved in synthesising autoinducer-2 that plays important roles in quorum sensing, aiding bacterial cell-to-cell crosstalk in co-cultures. The proteome of L. salivarius ZJ614 was most affected when co-cultured with L. reuteri ZJ625. In contrast, omitting some medium components from the defined medium exerted more effects on L. reuteri ZJ625 than L. salivarius ZJ614.
Analyse der Bildungsentscheidungen von (ehemaligen) Sportler*innen der Sportfördergruppen der Bundeswehr
Authors: Vollmann Franziska , Ehnold Peter , Schlesinger Torsten 
Published: August 2023

ZusammenfassungDie Sportfördergruppen der Bundeswehr stellen eine tragende Säule der Unterstützung von Spitzensportler*innen in Deutschland dar. Ziel der Sportförderung ist u. a. die Vereinbarkeit von Spitzensport und Beruf durch eine „Duale Karriere-/Laufbahnplanung“ sicherzustellen. Trotz wiederholter Kritik liegen jedoch bisher keine Befunde zu Dualen Karriereverläufen von Sportsoldat*innen vor. Der Beitrag untersucht, inwieweit Sportsoldat*innen während ihrer Zugehörigkeit zu den Sportfördergruppen Bildungsangebote nutzen und welche Faktoren ihre Entscheidungen beeinflussen. Die Analyse der Bildungsentscheidungen basiert auf dem Konzept der Humankapitaltheorie und berücksichtigt spezifische Besonderheiten des Spitzensports sowie institutionelle Förderbedingungen. In einer retrospektiven Längsschnittstudie wurden zeitbezogene Ereignisdaten zur Dualen Karriere von n = 712 (ehemaligen) Sportsoldat*innen erhoben. Von diesen sind 414 derzeit in einer Sportfördergruppe aktiv, während 298 Befragte die Sportförderguppen innerhalb der letzten zehn Jahre verlassen haben. Die Ergebnisse zeigen, dass insgesamt 80,6 % der (ehemaligen) Sportsoldat*innen mindestens eine Ausbildung begonnen haben. Während der Zugehörigkeit zu den Sportfördergruppen haben (bisher) 42,6 % eine Ausbildung (davon 86,7 % mindestens ein Studium) aufgenommen. Die Bildungsentscheidungen werden vorwiegend von Faktoren der Bildungsbiografie und der Förderung der Dualen Karriere in den Sportfördergruppen beeinflusst. Hingegen lässt sich keine (zu) optimistische Einschätzung der beruflichen Verwertbarkeit des im Spitzensport erworbenen symbolischen Kapitals (Reputation) feststellen.
Modelling overflow using mixed integer programming in short-term hydropower scheduling
Authors: Litlabø Tormod , Aaslid Per , Riise Tarjei Lid , Haugland Dag 
Published: August 2023

AbstractShort-term hydropower scheduling seeks to find a production schedule that maximizes profit, but must also consider the hydrological balance and risk of overflow. Overflow is by nature a non-linear and non-convex phenomenon. Common approximations and relaxations may cause non-physical results such as overflow from reservoirs that are not full. This paper presents a mixed-integer linear programming formulation that can be used to prevent non-physical overflow behaviour, but that comes at a cost of significant higher solving time. To achieve an acceptable solving time, we propose a heuristic to provide tight upper bounds on the overflow variables in each time step. When applied on the model of the Fossdal watercourse in Norway, the proposed method reduces the solving time with more than 90% compared to using a conservative fixed coefficient for all time steps.
Connecting Wetland Flooding Patterns to Insect Abundance Using High-Resolution Inundation Frequency Data
Authors: Åhlén Imenne , Jarsjö Jerker , Hambäck Peter A. 
Published: August 2023

AbstractFlood dynamics are important drivers of wetland biodiversity. With current climate and land-use changes affecting overall water cycling, many wetland ecosystems are at risk of degradation, affecting biodiversity support negatively. This emphasizes a need for understanding possible correlations between specific hydrological conditions and biodiversity support in wetlands, at least in terms of species composition. In this study, we used high resolution hydrological monitoring of water levels and insect sampling in a depressional wetland to investigate possible correlations between inundation patterns and insect abundance. Our results show that there is a high spatial and temporal heterogeneity in wetland inundation patterns and that this heterogeneity explains variation in insect abundance. This creates episodes of downstream wet and upstream dry conditions. In addition, the spatial variability was high between grid cells of 2 meter’s resolution. There were also indications that distance to stream affected insect community structure. The findings from this work show that that the local hydrological conditions can create heterogeneity in habitat conditions, which in turn lead to refuge habitats for species vulnerable to changes in inundation condition. This study also highlights the importance of acknowledging quantitative hydrological methods when assessing the relation to insect communities.
Development of DNA markers using next-generation sequencing approach for molecular authentication of Boerhavia diffusa L. and Tinospora cordifolia (Willd.) Miers
Authors: Sharma Anu Radha , Vohra Manik , Vinay Chigateri M. , Paul Bobby , Chakrabarty Sanjiban , Rai Padmalatha S. 
Published: August 2023

AbstractThe adulteration of plants and their materials used in herbal formulations poses a severe health concern. Hence, there is a need to establish a reliable, cost-effective, and robust molecular biomarker to distinguish among species and identify herbal plants and raw drugs from adulterants. The present study used suppressive subtractive hybridization and next-generation sequencing technology to identify novel DNA markers for Boerhavia diffusa L. and Tinospora cordifolia (Willd.) Miers. We identified two primer sets for B. diffusa and one for T. cordifolia. The DNA markers were validated in different accessions of B. diffusa and T. cordifolia and their common adulterants to determine the sensitivity and specificity of developed DNA markers. The designed DNA markers showed 100% sensitivity and specificity in detecting B. diffusa and T. cordifolia from their adulterants. The strategy described here can be extrapolated for developing DNA markers to authenticate other plant species.
Oral complications associated with metal ion release from oral piercings: a systematic review
Authors: Masood M. , Walsh L. J. , Zafar S. 
Published: August 2023

Abstract
Purpose
This systematic review explored dental complications associated with metal ion release from oral piercings using the Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines.

Methods
Item retrieval from October 2022 to December 2022 from databases, such as Cochrane Central Register of Controlled Trials, Medline, PubMed, Embase, Scopus and Web of Science, using predefined search terms was undertaken by two independent reviewers. Data were extracted and risk of bias was assessed using the Joanna Briggs Institute (JBI) critical appraisal checklist. From 1509 identified studies, 25 were included for analysis.

Results
Of the 25 studies, 20 included both clinical examination and questionnaire-based data. The remaining five studies were deemed low quality based on the Joanna Briggs Institute criteria. The average time piercings were worn ranged between 5 and 48 months. Most studies did not investigate complications from metal ion release. Only two studies examined the direct effects of metal ion release and showed that metal ions may cause hypersensitivity reactions and mucosal changes. Other soft tissue complications were reported, with gingival recession noted in 16 out of 25 studies, especially due to lip piercings. Studies reporting other complications were as follows: swelling (9), pain (8), infection (6), bleeding (6), inflammation (5), alterations to speech, eating and/or swallowing (5), changes to taste or metallic taste (5), and mucosal changes (4). Ten studies reported tooth chipping from tongue piercings.

Conclusion
Oral piercings leach metal ions into surrounding tissues which may cause local mucosal changes. Furthermore, oral piercings cause damage to both soft and hard oral tissues, particularly gingival recession for lip piercings and tooth chipping for tongue piercings. Thus, to prevent such adverse injuries, dental professionals should discourage patients against oral piercings.
Neurofilament-light chains (NF-L), a biomarker of neuronal damage, is increased in patients with severe sarcopenia: results of the SarcoPhAge study
Authors: Ladang Aurélie , Kovacs Stéphanie , Lengelé Laetitia , Locquet Médéa , Beaudart Charlotte , Reginster Jean-Yves , Bruyère Olivier , Cavalier Etienne 
Published: August 2023

Abstract
Background
As clinical tests, such as gait speed, require nervous system integrity to be performed properly, sarcopenia shares features with neurological diseases. Neurofilament light chains (NF-L) are now used as a blood-biomarker of neuronal damage, and its expression might be altered in sarcopenia. We aimed to assess NF-L concentrations in a large cohort of older individuals screened for sarcopenia.

Methods
The SarcoPhAge cohort is a Belgian cohort of 534 community-dwelling older adults with an ongoing 10-year follow-up. Sarcopenia diagnosis was established at inclusion according to the European Working Group on Sarcopenia in Older People 2 (EWGSOP2) criteria. Muscle strength was evaluated with a hydraulic hand dynamometer, appendicular lean mass by Dual-Energy X-ray Absorptiometry (DXA) and physical performance by the Short Physical Performance Battery (SPPB). NF-L was measured on all available sera collected at the time of inclusion (n = 409) using SiMoA technology (Quanterix°).

Results
In the multivariate model, NF-L was associated with performance tests such as gait speed (p < 0.0001) and SPPB scores (p = 0.0004). An association was also observed with muscle strength (p = 0.0123) and lean mass (p = 0.0279). In the logistic regression model, NF-L was an independent predictor of severe sarcopenia (p = 0.0338; OR = 20.0; 95% CI 1.39–287.7) with satisfactory diagnostic accuracy (AUC: 0.828) and subjects with an SPPB score ≤ 8 had higher odds of having increased NF-L (p < 0.0001; OR = 23.9; 95% CI 5.5–104).

Conclusions
These data highlight the potential for using NF-L to investigate the pathophysiology of sarcopenia severity and the neurological features associated with performance tests. However, these results need to be confirmed with other cohorts in different settings.
Equal Alternatives or Lower Standards for Immigrant Women—Analyzing Obstetric Care for Immigrant Women in Berlin Within the Framework of Cultural Health Capital
Authors: Großkreutz Claudia , Gürbüz Burcu , Borde Theda , Rancourt Rebecca C. , Henrich Wolfgang , David Matthias , Seidel Vera 
Published: August 2023

AbstractIn obstetric clinics in Berlin, Germany, more than half of the women are immigrants. The main objective of the qualitative study was to explore the staff’s experiences with obstetric care for immigrants and juxtapose it with the immigrants’ comments on their birth experiences. We analyze potential differences along the framework of a cultural health capital (CHC). Between May and August 2017, semi-structured interviews were carried out with 17 obstetricians and 17 midwives at four obstetric clinics in Berlin. The verbally transcribed interview material was subjected to a qualitative content analysis according to Mayring. Furthermore, a secondary data from an interview study was analyzed in the purpose of providing some insight into the practitioner study participant perspective. Between January and May 2017, in the postpartum ward at the Berlin Charité Campus Virchow Clinic, an interview study guided by the migrant-friendly maternity care questionnaire was conducted among 410 migrant and non-migrant women. For this study, the free-text comments on the pregnancy care were analyzed. The staff interviewees identified language barrier and legal status as risk factors for the late onset of obstetric care. CHC functioning potentially as alternatives to the established health care structures were voiced. Strong family ties among immigrant families bear a high potential for support. Gratefulness was voiced by the staff and immigrant patients as a source of satisfaction with care. Our study shows that obstetric care for immigrant women remains a challenge. CHC of immigrant women might partially compensate for exclusion.
Anti-allergen monoclonal antibodies for the treatment of allergies
Authors: Pengo Niccolo , Wuillemin Natascha , Bieli Dimitri , Gasser Pascal 
Published: August 2023

Abstract
Background
To tackle the growing allergy epidemic, novel therapeutic approaches are urgently needed. One promising avenue is the development of anti-allergen antibody therapies. This passive immunization approach stands out from traditional allergen immunotherapy by not exposing patients to the allergen but also by potentially treating patients who are less responsive or even unresponsive to allergen immunotherapies and providing immediate protection.

Methods
After a review of historical and recently published literature on the topic of anti-allergen antibodies, the status quo and recent advancements are presented. Anti-allergen antibody therapies in the context of immunological changes that occur during allergen immunotherapy are also discussed.

Results
While the protective role of anti-allergen antibodies was recognized decades ago, the advancement of antibody discovery technologies has fueled the field, and now different anti-allergen antibody therapies are approaching clinical use. These developments have also broadened our understanding of the allergens and allergenic epitopes responsible in different allergic diseases, and also the role played by immunoglobulins in shaping the immune system.

Conclusion
The development of anti-allergen antibody therapies offers great potential for the treatment of allergies. Of interest, the efficacy of passive immunization approaches will likely extend beyond allergen neutralization as in the presence of the allergen they might contribute to long-lasting disease modification.
RETRACTED ARTICLE: Multidimensional fuzzy norms and cut sets in the context of medical decision making
Authors: Josen Jomal , John Sunil Jacob 
Published: August 2023

AbstractThis study introduces the concepts of complements, t-norms, t-conorms, and cut sets in the context of multi-dimensional fuzzy sets. Some fundamental results including DeMorgan-type identities, concerning these, are obtained. The advantage of using multidimensional fuzzy sets for analyzing data is that each element in the universe can be given individual attention as per the requirement. By utilizing this scope, as an application of the introduced concepts, stage identification of certain diseases based on Multidimensional fuzzy sets and intuitionistic fuzzy sets is provided together with a comparative study on typical biomedical data.
Formal Modelling for Multi-Robot Systems Under Uncertainty
Authors: Street Charlie , Mansouri Masoumeh , Lacerda Bruno 
Published: August 2023

AbstractPurpose of ReviewTo effectively synthesise and analyse multi-robot behaviour, we require formal task-level models which accurately capture multi-robot execution. In this paper, we review modelling formalisms for multi-robot systems under uncertainty and discuss how they can be used for planning, reinforcement learning, model checking, and simulation.Recent FindingsRecent work has investigated models which more accurately capture multi-robot execution by considering different forms of uncertainty, such as temporal uncertainty and partial observability, and modelling the effects of robot interactions on action execution. Other strands of work have presented approaches for reducing the size of multi-robot models to admit more efficient solution methods. This can be achieved by decoupling the robots under independence assumptions or reasoning over higher-level macro actions.SummaryExisting multi-robot models demonstrate a trade-off between accurately capturing robot dependencies and uncertainty, and being small enough to tractably solve real-world problems. Therefore, future research should exploit realistic assumptions over multi-robot behaviour to develop smaller models which retain accurate representations of uncertainty and robot interactions; and exploit the structure of multi-robot problems, such as factored state spaces, to develop scalable solution methods.
An original donor-dependent spheroid system for the prediction of idiosyncratic drug-induced liver injury risk
Authors: Cherradi Sara , Taulet Nicolas , Duong Hong Tuan 
Published: August 2023

AbstractOne major drawback of preclinical models to test drug-induced liver injury (DILI) is their inability to predict the interindividual difference of DILI effect in a population. Consequently, a high number of molecules that passed preclinical phases, fail clinical trials, and many FDA-approved drugs were removed from the market due to idiosyncratic DILI. We use a proprietary-depleted human serum-based cell educating technology to generate donor-dependent spheroids with distinct morphology and functionality. We demonstrate that educated spheroids could capture the large variations in susceptibility to drug-induced liver injury between donors. We show that the model could predict clinical apparent DILI risk with a high specificity and sensitivity. We provide evidence that the model could address non-genetic factor-associated DILI risk and severity such as age or sex. Our study supports the benefit of using donor-dependent educated spheroids for hepatotoxicity evaluation in preclinical phase or in an exploratory study clinical trial phase 2 to provide a robust safety profile to a drug.
Total factor productivity and regional difference of tourism industry of listed companies
Authors: Xu Hongyi , Shen Yaqi , Wu Yixi , Xu Peng 
Published: August 2023

AbstractTourism industry has become a breakthrough point for China’s economic growth. As of 2019, the tourism economy has been maintaining a faster growth than the GDP growth rate, the entry and exit market has been developing steadily, the structural reform on the supply side has been effective, and the per capita income of China’s residents has grown significantly. In this context, this paper selects fifteen listed tourism companies in China as samples, uses the Malmquist index method in DEA to measure the total factor productivity of these fifteen companies in China as samples, analyzes their resource allocation efficiency, and tests the robustness of the empirical results. Three conclusions are obtained: from the overall perspective, the total factor productivity of fifteen listed companies as a whole shows an upward trend during the 5-year period, mainly due to the technological progress; from the year perspective, the Malmquist productivity index of China’s tourism industry shows a turnaround change during the 5-year period, and the operational efficiency shows regional differences; the fluctuations of various listed tourism companies in China are influenced by the environment and policies.