bluuebunny/crossref_metadata_2025_split huggingface dataset:
Targeted neonatal echocardiography and lung ultrasound in preterm infants with chronic lung disease with and without pulmonary hypertension, screened using a standardized algorithm
Authors: Sánchez-Becerra Janneth Cristina , Guillén-Torres Rogelio , Becerra-Becerra Rosario , Márquez-González Horacio , Ibarra-Ríos Daniel 
Published: March 2023

IntroductionIncreased recognition of the development of chronic pulmonary hypertension (cPH) in preterm infants with chronic lung disease (CLD) has prompted enhanced monitoring for the identification of different phenotypes.MethodsAll newborns consulted for oxygen/respiratory support dependency (CLD assessment) from January 2018 to December 2021 were included. TnECHO and LUS screening for cPH-CLD were performed at 36 weeks postmenstrual age. Cases of cPH related to increased pulmonary blood flow (cPH-IPBF) were referred to Pediatric Cardiology. The objective of the study was to identify all cases of cPH (cPH-CLD/IPBF) in the CLD patients screened and to compare outcomes. Following a standardized algorithm, cPH-CLD patients were treated with diuretics; ultrasounds taken before and after treatment were analyzed.ResultsSeventy-two patients with CLD were screened. Twenty-two (30%) had cPH-CLD, and nine (12%) had cPH-IPBF. cPH infants underwent more days of mechanical ventilation, were more likely to have retinopathy of prematurity, and showed increased mortality. The LUS pattern observed in the 72 CLD patients consisted of a thickened pleural line and a B-line interstitial heterogeneous pattern; 29% of patients were found to have lung consolidations. After diuretic therapy, step-down in respiratory support occurred in 59% of neonates with cPH-CLD. A decrease in respiratory rate (RR), right ventricular output (RVO), markers of pulmonary vascular resistance (PVR), and B-line pattern was observed. In tissue Doppler imaging, biventricular diastolic function was found to be modified after diuretics.ConclusionsCLD infants with cPH showed increased morbidity and mortality. In cPH-CLD patients, a decrease in RR and step-down in respiratory support was observed after diuretic treatment. Follow-up ultrasound showed a decrease in RVO, markers of PVR, and B-lines.
Fraxetin attenuates disrupted behavioral and central neurochemical activity in a model of chronic unpredictable stress
Authors: Ahmed Zainab , Tokhi Ahmed , Arif Mehreen , Rehman Naeem Ur , Sheibani Vahid , Rauf Khalid , Sewell Robert D. E. 
Published: March 2023

Purpose: Chronic unpredictable stress (CUS) induces long-term neuronal and synaptic plasticity with a neurohormonal disbalance leading to the development of co-existing anxiety, depression, and cognitive decline. The side effects and delayed onset of current clinically used antidepressants has prompted a quest for antidepressants with minimum drawbacks. Fraxetin is a natural coumarin derivative with documented antioxidant and neuroprotective activity though its effects on stress are unknown. This study therefore aimed to investigate any possible acute effect of fraxetin in behavioral tests including a CUS paradigm in correlation with brain regional neurochemical changes.Methods: Mice were subjected to a series of mild stressors for 14 days to induce CUS. Furthermore, behavioral performance in the open field test, forced swim test (FST), Y-maze and elevated plus-maze were evaluated. Postmortem frontal cortical, hippocampal and striatal tissues were analyzed via high-performance liquid chromatography (HPLC) for neurochemical changes.Result: Acute administration of fraxetin (20–60 mg/kg, orally) decreased depression-like behavior in the FST and behavioral anxiety in both the open field test and elevated plus-maze. Memory deficits induced during the CUS paradigm were markedly improved as reflected by enhanced Y maze performance. Concurrent biochemical and neurochemical analyses revealed that only the two higher fraxetin doses decreased elevated serum corticosterone levels while diminished serotonin levels in the frontal cortex, striatum and hippocampus were reversed, though noradrenaline was only raised in the striatum. Concomitantly, dopamine levels were restored by fraxetin at the highest dose exclusively in the frontal cortex.Conclusion: Acute treatment with fraxetin attenuated CUS-induced behavioral deficits, ameliorated the increased corticosterone level and restored altered regional neurotransmitter levels and this may indicate a potential application of fraxetin in the management of anxiety and depression modeled by CUS. However, further studies are warranted regarding the chronic effects of fraxetin behaviorally and neurochemically.
Association between maternal second-trimester stress and adverse pregnancy outcomes according to pre-pregnancy body mass index and gestational weight gain
Authors: Zhang Lixia , Zhu Shuqi , Wu Yihui , Chen Danqing , Liang Zhaoxia 
Published: March 2023

ObjectiveTo investigate the impact of maternal second-trimester stress on pregnancy outcomes according to pre-pregnancy body mass index (BMI) and gestational weight gain (GWG).MethodsWe did a prospective study in Women’s Hospital, School of Medicine, Zhejiang University and included 960 pregnant women in our final analysis. Obstetric characteristics and the incidence of adverse pregnancy outcomes were examined in stressed and non-stressed women. The associations between maternal prenatal stress with adverse pregnancy outcomes were analyzed by logistic regression.ResultsThe incidence of premature rupture of membranes (PROM) was significantly higher in stressed pregnant women than non-stressed pregnant women (p = 0.035), whereas no significant difference in the incidence rates of gestational diabetes mellitus (GDM), pregnancy-induced hypertension (PIH), primary cesarean delivery, preterm birth, macrosomia, low birth weight, fetal stress, admission into neonatal intensive care unit (NICU) or neonatal jaundice was found between two groups. Maternal second-trimester stress was an independent risk factor for the development of PROM (aOR = 1.468, 95% CI 1.037–2.079). Moreover, maternal second-trimester stress was significantly associated with PROM in pregnant women with normal pre-pregnancy BMI (aOR = 1.587, 95% CI 1.068–2.357) while no association was observed in either underweight or overweight and obese pregnant women. Meanwhile, no difference was found in the odds of PROM with maternal second-trimester stress in all GWG subgroups.ConclusionMaternal second-trimester stress is associated with a higher risk of PROM and it is significant in pregnant women with normal pre-pregnancy BMI. Therefore, interventions to reduce stress during second-trimester of pregnancy might be essential for lowering the prevalence of PROM in pregnant women with normal pre-pregnancy BMI.
Determinants of severe QTc prolongation in a real-world gerontopsychiatric setting
Authors: Schulze Westhoff Martin , Schröder Sebastian , Heck Johannes , Pfister Tabea , Jahn Kirsten , Krause Olaf , Wedegärtner Felix , Bleich Stefan , Kahl Kai G. , Krüger Tillmann H. C. , Groh Adrian 
Published: March 2023

IntroductionQTc prolongation carries the risk of ventricular tachyarrhythmia (Torsades de Pointes) and sudden cardiac death. Psychotropic drugs can affect ventricular repolarization and thus prolong the QTc interval. The present study sought to investigate the risk factors (pharmacological and non-pharmacological) of severe QTc prolongation in gerontopsychiatric patients.MethodsElectrocardiograms of patients on a gerontopsychiatric ward were screened for QTc prolongation. Medication lists were examined utilizing the AzCERT classification. Potential drug interactions were identified with the electronic drug interaction program mediQ.ResultsThe overall prevalence of QTc prolongation was 13.6%, with 1.9% displaying severe QTc prolongation (≥ 500 ms). No statistically significant differences between patients with moderate and severe QTc prolongation were identified; however, patients with severe QTc prolongation tended to take more drugs (p = 0.063). 92.7% of patients with QTc prolongation took at least one AzCERT-listed drug, most frequently risperidone and pantoprazole. Risperidone and pantoprazole, along with pipamperone, were also most frequently involved in potential drug interactions. All patients displayed additional risk factors for QTc prolongation, particularly cardiac diseases.ConclusionIn addition to the use of potentially QTc-prolonging drugs, other risk factors, especially cardiac diseases, appear to be relevant for the development of QTc prolongation in gerontopsychiatric patients. Pantoprazole was frequently involved in potential drug interactions and should generally not be used for more than 8 weeks in geriatric populations. As clinical consequences of QTc prolongation were rare, potentially QTc-prolonging drugs should not be used overcautiously; their therapeutic benefit should be considered as well. It is paramount to perform diligent benefit–risk analyses prior to the initiation of potentially QTc-prolonging drugs and to closely monitor their clinical (side) effects.
Assessing the impact of local context and priorities regarding domestic disease outbreaks and imported risk on early pandemic response: Cross-continental comparisons
Authors: Kuo Fei-Ying , Wen Tazi-Hung 
Published: March 2023

IntroductionContainment and closure policies are effective measures used in the early stages of a highly transmissible global pandemic such as COVID-19 to mitigate the spread and reduce transmissions. However, these policies can have negative impacts on the economy and personal freedom. Governments must carefully consider the necessity of increasing their stringency. Local contexts and priorities regarding domestic disease outbreaks and the risk of imported cases from other countries may vary among different countries, and could influence the decision to increase containment measures. Thus, this study aimed to differentiate the impacts of these affecting factors on the stringency of governmental containment measures through cross-continental comparisons.MethodsThis study utilized a zero/one inflated beta (ZOIB) regression model to investigate how domestic epidemic, imported risk, and local context affect government responses to a pandemic. We used a country’s weekly confirmed case and death numbers as a measure of its domestic threat. The imported risk was measured using a combination of weekly new cases in each country and the air passenger traffic between countries.ResultsThe findings indicate that domestic case numbers are a primary concern for governments when deciding to increase policy stringency. Countries with higher development levels tend to implement stricter policies as they can better handle the negative impacts. Additionally, there is an interaction between case numbers and development level, with countries at the second or third highest development level focusing more on domestic outbreaks than imported risks, while those at the highest level have similar concerns for both.ConclusionsWe concluded that most countries adjust policies’ stringency majorly based on the variation of domestic case number rather than the other pandemic factors and the countries with a high development level tend to implement strict policies since their socio-economical condition could afford such policies. These insights can aid policymakers in improving containment and closure policies for future pandemics.
Temporal Trends in the Incidence and Mortality of Major Reproductive-Related Cancers in Women in Guangzhou From 2010 to 2020: A Joinpoint and Age-Period-Cohort Study
Authors: Wang Suixiang , Liu Shan , Nie Zhiqiang , Li Yexin , Li Ke , Liang Huanzhu , Chen Qian , Wen Lin , Xu Huan , Liang Boheng , Qin Pengzhe , Jing Chunxia 
Published: March 2023

Objective: To understand the temporal trends of cancer incidence and mortality in women in Guangzhou during the past 11 years and provide clues for future research.Methods: Data were obtained from the Guangzhou Cancer and Death Registry. Average annual percentage changes (AAPCs) in age-standardized incidence rates (ASIRs) and age-standardized mortality rates (ASMRs) were obtained by joinpoint regression. The age-period-cohort (APC) model was generated to quantify the effects of age, period, and cohort.Results: The ASIRs for cervical (AAPC = −4.3%) and ovarian (AAPC = −3.2%) cancers showed a downward trend during 2010–2020, and that for uterine cancer showed an upward trend. The ASMRs of breast (APC = 5.0%) and cervical (APC = 8.8%) cancers increased. The APC model highlights different age, period, and birth cohort effects depending on the cancer site.Conclusion: The ASIRs for cervical and ovarian cancers among women in Guangzhou showed a decreasing trend during the period. The APC model showed mortality for 4 cancers increased with age. Incidence and mortality decreased with increasing birth cohort. Annual reproductive cancer screening is recommended for women of appropriate age to reduce the disease burden.
Management and Outcome After Early Renal Transplant Vein Thrombosis: A French Multicentre Observational Study of Real-Life Practice Over 24 Years
Authors: Cambou Ludivine , Millet Clémentine , Terrier Nicolas , Malvezzi Paolo , Timsit Marc-Olivier , Anglicheau Dany , Badet Lionel , Morelon Emmanuel , Prudhomme Thomas , Kamar Nassim , Lejay Anne , Perrin Peggy , Uro-Coste Charlotte , Pereira Bruno , Heng Anne Elisabeth , Garrouste Cyril , Guy Laurent 
Published: March 2023

Early (&lt;14 days) renal transplant vein thrombosis posttransplant (eRVTPT) is a rare but threatening complication. We aimed to assess eRVTPT management and the rate of functional renal transplantation. Of 11,172 adult patients who had undergone transplantation between 01/1997 and 12/2020 at 6 French centres, we identified 176 patients with eRVTPT (1.6%): 16 intraoperative (Group 1, G1) and 160 postoperative (Group 2, G2). All but one patient received surgical management. Patients in group G2 had at least one imaging test for diagnostic confirmation (N = 157, 98%). During the operative management of the G2 group, transplantectomy for graft necrosis was performed immediately in 59.1% of cases. In both groups, either of two techniques was preferred, namely, thrombectomy by renal venotomy or thrombectomy + venous anastomosis repair, with no difference in the functional graft rate (FGR) at hospital discharge (p = NS). The FGR was 62.5% in G1 and 8.1% in G2 (p &lt; 0.001). Numerous complications occurred during the initial hospitalization: 38 patients had a postoperative infection (21.6%), 5 experienced haemorrhagic shock (2.8%), 29 exhibited a haematoma (16.5%), and 97 (55.1%) received a blood transfusion. Five patients died (2.8%). Our study confirms the very poor prognosis of early renal graft venous thrombosis.
التعسف في استعمال حق دفع الصائل على النفس في الفقه الإسلامي مقارنًا بالفقه القانوني الجنائي
Authors: Haddad Faten Mazen 
Published: March 2023

الأهداف: تهدف هذه الدراسة للتحقق من إمكان تطبيق نظرية التعسف في استعمال الحق على حق دفع الصائل على النفس في الشريعة الإسلامية، وبيان الرأي القانوني حيال ذلك، ومناقشته.
المنهجية: قامت هذه الدراسة على استعمال المنهج الوصفي؛ لإثبات مشروعية حق دفع الصائل عن النفس في الشريعة الإسلامية والفقه القانوني، وحدود هذا الحق، والمنهج المقارن؛ للمقارنة بين الشريعة والفقه القانوني في تصور وقوع التعسف في استعمال هذا الحق، والمنهج الاستنباطي؛ لاستخراج حالات وقوع التعسف في استعمال هذا الحق بتطبيق معايير النظرية الفقهية على ممارسة هذا الحق.
النتائج: خلصت الدراسة إلى نتيجة ثبوت التعسف في استعمال حق دفع الصائل على النفس في واحد من معايير النظرية، وهو المعيار الذاتي الشخصي، دون المعيار الموضوعي؛ فالتعسف في استعمال هذا الحق يثبت حين تظهر نية الانتقام وليس نية الدفاع. والمخالفات في دفع الصائل في الجانب الموضوعي المتعلق بأفعال الدفع ترجع كلها إلى إثبات وقوع التعدي والتجاوز من المدافع، وهذا التعدي خروج عن حدود الحق، وليس تعسفًا في استعمال الحق.
الخلاصة: خلصت الدراسة إلى أهمية التوسع في الدراسات المتعلقة بنظرية التعسف في استعمال الحق في سائر الحقوق، دون الاقتصار على الحقوق المدنية فحسب.
Experimental demonstration of spatial division multiplexing multiple-input/multiple-output underwater acoustic communication using a time-reversal method at the depth of the continental shelf: a consideration of optimization of signal length and number of transmission channels
Authors: Kida Yukihiro , Deguchi Mitsuyasu , Shimura Takuya 
Published: March 2023

Abstract
In this paper, the performance of the adaptive passive time-reversal method is investigated for an at-sea experiment of multiple-input/multiple-output underwater acoustic communication over a range of 13.5 km. The experiment was conducted at a depth of 200 m utilizing up to five transmitters with 4–8.5 kHz signal bandwidth for spatial division multiplexing. It was confirmed that the performance depends on the delay time from the timing of the channel response estimation to the communication signal reception, and the optimal signal length and the number of transmission channels can be determined according to the required bit error rate (BER) for the system. As a result, using the optimal signal length and a number of transmission channels, effective data rates of 30.21 and 37.53 kbps are achieved with BER ranges of less than 0.1% and 1%, respectively, with more than 90% of received communication signal packets.
Acoustic metasurfaces and topological phononics for acoustic/elastic device design
Authors: Tsuruta Kenji 
Published: March 2023

Abstract
This paper reviews recent progress in acoustic metasurfaces and the novel concept of “topological acoustic/phononics” for designing compact yet efficient acoustic devices. After a brief review of this research area and its impact on ultrasonic technologies, some of the efforts to develop highly efficient sound absorption devices using acoustic metasurfaces are introduced. A resonance-based mechanism to achieve efficient absorption in metasurface structures thinner than the wavelength of the incident sound is briefly discussed, and its extensions to a broad spectrum are highlighted. Next, a valley topological phononic system is introduced, and its applications to the design of phononic waveguides are exemplified. The band structure design for extracting topologically protected edge modes is shown together with a numerical and experimental demonstration of the robustness of phononic waveguides constructed in both acoustic and elastic regimes.
Harnessing conventional wisdom for rain water harvesting to mitigate the risks of climate change
Authors: Patel Mahesh , Pant Vartika , Sikligar Hesha , Quadri Sanila , Bachar Nabajit , Maurya Nitin 
Published: March 2023

Rain water harvesting is the process of collection and storage of rain for various purposes. Rainwater harvesting continues to be the main source of water supply for potable and non-potable uses. Located in a hot and semi-arid region with water scarcity, the National Innovation Foundation - India (NIF) identified a need to conserve water for office use. Building upon the expertise and experience of Lok Mitra Trust in this field, NIF got built traditional, but unique type of rain water harvesting tanks also known as “Matka tank” at its headquarters in Gandhinagar, Gujarat. The unique features of the tank are its hemispherical shaped upper dome and saucer shaped bottom surface, which is being reported for the first time.The Matka tank for rain water harvesting may be considered as a sustainable technique to mitigate the water scarcity in the context of climate change.
Effect of various soil health indicators on rice productivity in old alluvium of Bihar: A correlation study
Authors: Nath Debabrata , Laik Ranjan , Poonia Shishpal , Kumari Vandana 
Published: March 2023

Conventional method of rice-wheat cropping system leads to deteriorate soil health drastically day by day. An appropriate idea of particular soil health indicator that effects soil health directly should be known to make the crop productivity high. In order to determine the direct and indirect associations among various soil health properties with rice yield in rice-wheat cropping system a survey was done in farmer’s field. Overall 100 soil samples were collected randomly from 100 farmer’s field and studied to find out the soil health. Soil chemical properties (pH, EC, SOC, Avl. N, Avl. P2O5, Avl. K20), Soil physical properties (sand, silt, clay and Available water capacity) and soil biological properties (active carbon, soil respiration and autoclaved citrate extractable protein) were studied to find out the principal indicator for soil health that effects directly to rice yield. The study revealed that mainly soil organic carbon effects rice yield directly along with clay content of soil and soil respiration. Soil microbial activity is also very important in order to achieve good rice yield and positive correlated soil respiration value is evidence of it. Thus the results suggest that farmers should focus on enhancing soil organic carbon and microbial activity by means of soil respiration with best sustainable management practices in order to achieve higher productivity of rice.
Embolización endovascular en hemorragia intraparenquimatosa temporo-occipital por fistula arteriovenosa. Reporte de caso
Authors: Palacios Palacios Angely Tatiana , Mercado González Andrés Felipe , Yunga Guamán. Milton Paul , Abril Valdez. David Sebastian 
Published: March 2023

Las malformaciones arteriovenosas cerebrales son una patología infrecuente, de las cuales las malformaciones fistulosas son las menos comunes; el manejo clínico quirúrgico no está totalmente definido por lo que analizar la eficacia de la embolización en estos pacientes constituye un aporte científico importante para la sociedad.
Paciente masculino de 28 años, con cefalea de 10/10 en escala visual analógica del dolor, se le realizan estudios de imagen y se evidencia una hemorragia intraparenquimatosa , en la angiotomografía computarizada revela ruptura de malformación arteriovenosa cerebral en la región temporo occipital dependiente de la arteria cerebral media; se realiza una embolización endovascular compleja, con resultados favorables en su evolución.
En conclusión la embolización como tratamiento de malformación arteriovenosa temporo occipital hemorrágica, es una alternativa viable en pacientes en estadio IV en escala de Spetzler.
Análisis temporal y espacial del ozono en tres distritos de Lima y su relación con el parque automotor
Authors: Huancare Medina Milagros Eva 
Published: March 2023

El Parque automotor es uno de los precursores potenciales del ozono y fuente de emisiones de partículas en aerosol. Anualmente el número de automóviles en las calles aumenta generando contaminación. La contaminación del aire es un problema critico en las áreas urbanas por lo que una compresión amplia de sus características espacial-temporal es importante para desarrollar políticas públicas. En el año 2017 la adquision de vehículos livianos en el Perú creció en un 6.4% en referencia al año 2016 teniendo un total de 163,668 unidades este incremento genera un aumento progresivo a los precursores del ozono. Este estudio se centra en la distribución y los cambios en las concentraciones de ozono y sus precursores (es decir, NOx NO, NO2) en Lima durante el período de un año comprendido en el año 2017. Se investigaron los efectos de los precursores y las condiciones meteorológicas (temperatura, humedad, velocidad del viento) sobre el ozono utilizando datos de 03 estaciones de Monitoreo del Servicio Nacional de Meteorología e Hidrología (SENAMHI) en los distritos de Puente Piedra zona norte, Santa Anita zona Este y Jesús María zona centro. Asimismo, el distrito de Puente Piedra presentó valores más altos del ozono durante todo el año (promedio de 7,01 µg/m3) debido a las condiciones meteorológicas locales. Los factores que tuvieron mayor relación con los niveles del ozono en el año 2017 en los 3 distritos de Lima fueron: emisiones de los NO por actividad vehicular y en menor preponderación por el clima cálido, vientos del sur hacia noreste y poca dispersión del contaminante. Aunque las fuentes móviles y residentes juegan un papel importante en la liberación de precursores, los resultados también indican un efecto significativo de las condiciones meteorológicas sobre los cambios en la concentración de ozono.