bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cell wall-related genes and lignin accumulation contribute to the root resistance in different maize (Zea mays L.) genotypes to Fusarium verticillioides (Sacc.) Nirenberg infection
Authors: Quiroz-Figueroa Francisco Roberto , Cruz-Mendívil Abraham , Ibarra-Laclette Enrique , García-Pérez Luz María , Gómez-Peraza Rosa Luz , Hanako-Rosas Greta , Ruíz-May Eliel , Santamaría-Miranda Apolinar , Singh Rupesh Kumar , Campos-Rivero Gerardo , García-Ramírez Elpidio , Narváez-Zapata José Alberto 
Published: June 2023

IntroductionThe fungal pathogen Fusarium verticillioides (Sacc.) Nirenberg (Fv) causes considerable agricultural and economic losses and is harmful to animal and human health. Fv can infect maize throughout its long agricultural cycle, and root infection drastically affects maize growth and yield.MethodsThe root cell wall is the first physical and defensive barrier against soilborne pathogens such as Fv. This study compares two contrasting genotypes of maize (Zea mays L.) roots that are resistant (RES) or susceptible (SUS) to Fv infection by using transcriptomics, fluorescence, scanning electron microscopy analyses, and ddPCR.ResultsSeeds were infected with a highly virulent local Fv isolate. Although Fv infected both the RES and SUS genotypes, infection occurred faster in SUS, notably showing a difference of three to four days. In addition, root infections in RES were less severe in comparison to SUS infections. Comparative transcriptomics (rate +Fv/control) were performed seven days after inoculation (DAI). The analysis of differentially expressed genes (DEGs) in each rate revealed 733 and 559 unique transcripts that were significantly (P ≤0.05) up and downregulated in RES (+Fv/C) and SUS (+Fv/C), respectively. KEGG pathway enrichment analysis identified coumarin and furanocoumarin biosynthesis, phenylpropanoid biosynthesis, and plant-pathogen interaction pathways as being highly enriched with specific genes involved in cell wall modifications in the RES genotype, whereas the SUS genotype mainly displayed a repressed plant–pathogen interaction pathway and did not show any enriched cell wall genes. In particular, cell wall-related gene expression showed a higher level in RES than in SUS under Fv infection. Analysis of DEG abundance made it possible to identify transcripts involved in response to abiotic and biotic stresses, biosynthetic and catabolic processes, pectin biosynthesis, phenylpropanoid metabolism, and cell wall biosynthesis and organization. Root histological analysis in RES showed an increase in lignified cells in the sclerenchymatous hypodermis zone during Fv infection.DiscussionThese differences in the cell wall and lignification could be related to an enhanced degradation of the root hairs and the epidermis cell wall in SUS, as was visualized by SEM. These findings reveal that components of the root cell wall are important against Fv infection and possibly other soilborne phytopathogens.
Relationship between psychological adaptability and work engagement of college teachers within smart teaching environments: the mediating role of digital information literacy self-efficacy
Authors: Fan Shiyi , Yu Zeyuan , Zheng Xin , Gao Chunhai 
Published: June 2023

IntroductionIntegrating the Internet and traditional teaching has enriched teaching resources and methods and introduced many advanced digital media. The smart teaching process is influenced by teachers' psychological adaptability, which can be affected by teachers' work engagement. However, the relationship between the two has not received sufficient attention in the literature. This study aims to analyze the relationship between college teachers' psychological adaptability and work engagement in a smart teaching environment.MethodsApplying structural equation modeling (SEM) to a sample of 373 front-line teachers, this study focuses on the mediating effect of digital information literacy self-efficacy on the relationship between teachers' psychological adaptability and work engagement.ResultsThe results show that the four dimensions of college teachers' psychological adaptability strongly influence work engagement and digital information literacy self-efficacy. In particular, teachers' psychological adaptability and work engagement are positively correlated; teachers' self-efficacy can positively affect the three dimensions of their work engagement, and teachers' psychological adaptability can positively affect their digital information literacy self-efficacy.ConclusionThe above results can serve as a basis for the development and improvement of the training of college teachers and the implementation of smart teaching. The study findings highlight the importance of training teachers on information technology teaching and implementing measures to enhance teachers' digital information literacy self-efficacy. Training should focus on the knowledge and skills of teachers using information technology teaching and increase the practical links of teachers using information technology teaching.
Rapid, sensitive, and highly specific detection of monkeypox virus by CRISPR-based diagnostic platform
Authors: Gong Lin , Chen Xiaomin , Wang Yimei , Liang Jiansheng , Liu Xiaoli , Wang Yi 
Published: June 2023

BackgroundMonkeypox (MPX), caused by the Monkeypox virus (MPXV), has incurred global attention since it broke out in many countries in recent times, which highlights the need for rapid and reliable diagnosis of MPXV infection.MethodsWe combined recombinase polymerase amplification (RPA) with CRISPR/Cas12a-based detection to devise a diagnostic test for detection of MPXV and differentiation of its two clades [Central Africa clade (MPXV-CA) and West Africa clade (MPXV-WA)], and called it MPXV-RCC. The sensitivity, specificity and practicability of this method have been analyzed.ResultsThe optimal conditions of MPXV-RCC assay include two RPA reactions at 38°C for 25 min and a CRISPR/Cas12a-gRNA detection at 37°C for 10 min. The results of MPXV-RCC assay were indicated by a real-time fluorescence analysis software. Thus, the whole detection process, including rapid template preparation (20 min), RPA reaction (25 min) and CRISPR-based detection (10 min), could be finished within 1 hour. The sensitivity of MPXV-RCC for MPXV-CA and MPXV-WA detection was down to 5~10 copies of recombination plasmids and pseudovirus per reaction. Particularly, MPXV-RCC assay could clearly differentiate MPXV-CA from MPXV-WA, and had no cross-reactivity with other pathogens. In addition, the feasibility of MPXV-RCC assay was further validated by using spiked clinical samples.ConclusionThe MPXV-RCC assay developed here is a promising tool for quick and reliable diagnosis of MPXV infection.
Canine salivary gland carcinoma treated with stereotactic body radiation therapy: a retrospective case series
Authors: Gualtieri Patricia , Martin Tiffany , Leary Del , Lana Susan E. , LaRue Susan M. , Boss Mary-Keara 
Published: June 2023

ObjectiveThe aim of this study was to describe the therapeutic outcomes of dogs with locally advanced salivary gland carcinomas (SGC) following stereotactic body radiation therapy (SBRT).MethodsA single institution retrospective study was conducted of client-owned dogs with macroscopic SGC treated with SBRT. Patient signalment, clinical characteristics, and treatment parameters were recorded. Clinical benefit was determined based on follow-up physical examination and medical history. Progression-free interval (PFI), median survival time (MST), and disease-specific survival (DSS) were calculated using Kaplan–Meier analysis. Acute and late toxicity were recorded according to Veterinary Radiation Therapy Oncology Group (VRTOG) criteria.ResultsSix patients were included in the study. Tumor origins were mandibular (n = 3), parotid (n = 2), and zygomatic (n = 1) salivary glands. The SBRT prescription was 10 Gy × 3 daily or every other day. All patients (100%) experienced clinical benefit from treatment at a median time of 34 days (range 28–214). No local or regional nodal failure was reported following SBRT. Progressive pulmonary metastatic disease was documented in three dogs (50%). The median PFI was 260 days (range 43–1,014) and the MST was 397 days (range 185–1,014). Median DSS was 636 days (range 185–1,014). Four dogs (66.6%) died of confirmed or suspected metastatic SGC. The reported acute side effects included grade 2 mucositis (n = 1) and vision loss (n = 1). No late side effects were recorded.ConclusionThis study suggests that SBRT may provide durable local control for invasive SGC in dogs. Further investigation in a larger cohort of patients is warranted. The incidence of reported acute and late toxicity was low.
Passive Transfer of Animal-Derived Polyclonal Hyperimmune Antibodies Provides Protection of Mice from Lethal Lassa Virus Infection
Authors: Oestereich Lisa , Müller-Kräuter Helena , Pallasch Elisa , Strecker Thomas 
Published: June 2023

Background: Lassa virus (LASV) can cause severe acute systemic infection in humans. No approved antiviral drugs or vaccines are currently available. Antibody-based therapeutics are considered a promising treatment strategy in the management of LASV disease. Methods: We used chimeric Ifnar−/− C57BL/6 (Ifnar−/− Bl6) mice, a lethal LASV mouse model, to evaluate the protective efficacy of polyclonal antibodies purified from sera of rabbits hyperimmunized with virus-like particles displaying native-like LASV glycoprotein GP spikes. Results: Polyclonal anti-LASV GP antibodies provided 100% protection against lethal LASV infection in a pre- and post-exposure treatment setting and prevented LASV disease. Treatment also significantly lowered viremia level and virus load in organs. When treatment was initiated at the onset of symptoms, the hyperimmune antibodies provided partial protection and increased the survival rate by 80%. Conclusions: Our findings support the consideration of animal-derived hyperimmune antibodies targeting GP as an effective treatment option for highly pathogenic LASV.
Second harmonic generation from a-plane GaN vertical monolithic microcavity pumped with femtosecond laser
Authors: Nambu Tomoaki , Nakahara Tomohiro , Yasuda Yuma , Fujiwara Yasufumi , Tonouchi Masayoshi , Uemukai Masahiro , Tanikawa Tomoyuki , Katayama Ryuji 
Published: June 2023

Abstract
We have proposed highly efficient microcavity second harmonic generation devices. In this work, we designed and fabricated an a-plane GaN vertical monolithic microcavity second harmonic generation device pumped with a femtosecond laser and obtained normalized wavelength conversion efficiency of 0.15% W−1. The efficiency was comparable to the theoretical estimations taking into account the time evolution of fundamental wave intensity in the microcavity, second harmonic generation and even sum frequency generation. This result indicates the possibility of realizing ultra-compact and ultra-efficient devices pumped with long-pulsed or continuous wave lasers, in which the effect of resonance enhancement is even more pronounced.
Repair Schemes of Rack-Aware Reed-Solomon Codes: Providing A Tradeoff Between the Sub-Packetization Size and the Cross-Rack Repair Bandwidth
Authors: Lin Xing 
Published: June 2023

<p>In practical data centers, storage nodes are grouped and distributed in different racks, where the communication cost across racks is much more expensive than that within rack. The concept of rack-aware maximum distance separable (MDS) codes has been put forward in recent literatures to deal with rack architecture. In this paper, the cross-rack repair bandwidth and sub-packetization size of rack-aware Reed-Solomon (RS) codes are studied. Cross-rack repair bandwidth is defined as the amount of information transmitted between the racks in the repair process of a failed node. RS codes can be regarded as polynomials over a finite field $GF(q^t)$ evaluated at a set of points, where $t$ is referred to as the sub-packetization size. Smaller cross-rack repair bandwidth decreases the network usage in data centers, and smaller sub-packetization size is conducive to the implementation of RS code with lower complexity. Previous RS codes that reach the rack-aware cut-set bound on cross-rack repair bandwidth either have sub-packetization size exponential in the code length or require strictly limited parameter conditions.</p>
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<p>In this paper, the lower bound on the cross-rack repair bandwidth related to sub-packetization size for rack-aware RS codes is given, which is asymptotically reachable under some parameters, and three repair schemes of rack-aware RS codes which provide a tradeoff between the sub-packetization size and the cross-rack repair bandwidth are shown.</p>
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EFEK PEMBERIAN ANTIBIOTIK JANGKA PANJANG PADA ANXIETAS MENCIT (Mus musculus)
Authors: Ambar Sulianti , Dadang Sahroni , Endi Endi , Devina Nurul Azizatunnisa , Syifa Rahma Tsania 
Published: June 2023

Penggunaan antiobitik meningkat di masa pandemi Covid-19 terutama pada penanganan kasus-kasus dengan komorbid dan infeksi di Indonesia. Antibiotik dapat menurunkan jumlah kolonisasi flora normal (mikrobioma) dalam usus sehingga berdampak kepada poros usus-otak. Penelitian ini bertujuan menganalisis pengaruh antibiotik jangka panjang terhadap tingkat kecemasan pada mencit (Mus musculus). Metode penelitian ini menggunakan Quasi Experimental Research dengan desain pre-post test dengan kelompok kontrol. Bertindak sebagai objek penelitian, total 84 mencit digunakan pada penelitian ini yang terbagi menjadi kelompok eksperimen dan kontrol masing-masing sebanyak 42 mencit. Kelompok eksperimen diberikan antibiotik jenis Ciprofloxacin selama 12 hari. Kecemasan pada mencit diukur menggunakan The Successive Alleys Test. Data yang diperoleh dianalisis menggunakan Mann Whitney karena tidak berdistribusi normal. Hasil penelitian menunjukkan perbedaan kecemasan lebih tinggi pada kelompok eksperimen sangat signifikan (p=0.000). Kesimpulan penelitian ini adalah antibiotik jangka panjang meningkatkan kecemasan pada Mus musculus. Dengan demikian pada penggunaan antibiotik jangka panjang perlu diwaspadai dampaknya terhadap poros usus-otak. .
Implementasi Literasi Digital Di Kalangan Mahasiswa Pendidikan Biologi ITS NU Pasuruan
Authors: Nanda D.A Ema , Maisaroh Siti , Fitriyah Siti , Diniyah Chikmah 
Published: June 2023

This study aims to determine the effectiveness of digital literacy implementation among students. The research method used is a survey method by distributing questionnaires online through the google form platform. Based on the results of research conducted on 31 female students of the ITS NU Pasuruan biology education study program class 22d-A, it was found that 74.2% or 23 of the 31 respondents used gadgets every day, while 19.4% or 6 of the 31 respondents used gadgets every day but rarely used gadgets. And the remaining 6.5% or 2 out of 31 only use gadgets several times a week. So it can be concluded that almost all biology education students in class 22d-A stated that they use gadgets every day, with a percentage of 74.2% or 23 out of 31 respondents. All 22d-A ITSNU Pasuruan biology education study program students have access and understanding of sophisticated technology, but not all of them have an interest or preference for digital literacy. The current learning process also utilizes technology according to current needs. It is imperative that individuals are able to improve their digital literacy skills. This is because digital technology is also very supportive of a person's process in developing themselves and seeking as much knowledge as possible without any time and space limitations.
PEMBERIAN ASIMILASI NARAPIDANA RESIDIVIS (STUDI KASUS DI L.P. PEREMPUAN KELAS IIA MALANG)
Authors: Nurhidayanto Moch Syamsudin 
Published: June 2023

The policy of assimilation of prisoners in the midst of the COVID-19 pandemic, namely the Regulation of the Minister of Law and Human Rights of the Republic of Indonesia Number 10 of 2020 concerning Conditions for Providing Assimilation and Integration for Prisoners and Children in the Framework of Prevention and Countermeasures of the Spread of COVID-19 is very interesting to be further peeled. The policy received a lot of support as well as criticism from many parties. Many people worry about the repetition of crimes committed by ex-assimilation prisoners. Based on the background above, the author raised the formulation of the problem as follows: "How is the legal politics of Regulation of the Minister of Law and Human Rights of the Republic of Indonesia Number 10 of 2020 against recidivist prisoners in Malang Class IIA Women's Prison?" The method used in this writing is an empirical juridical method with a sociological approach that seeks to describe the implementation Regulation of the Minister of Law and Human Rights of the Republic of Indonesia Number 10 of 2020 in people's lives. Primary data collection is done by interview while secondary data is obtained from library studies and documents related to research problems. The results of the review explained that the strategy for handling prisoners who commit crimes again after being released through the assimilation program at home carried out at the Malang Class IIA Women's Prison is in accordance with Regulation of the Minister of Law and Human Rights of the Republic of Indonesia Number 10 of 2020 concerning Conditions for Providing Assimilation and Integration Rights for Prisoners and Children in the Framework of Prevention and Countermeasures of the Spread of COVID-19. The legal politics applied to keep recidivism rates low are to impose more severe sanctions on inmates and children who repeat their crimes. In the Women's Penitentiery Class IIA Malang, there are 1 (one) recidivist prisoner who is free of COVID assimilation and is currently locked in a straft cell at women’s penitentiery Class IIA Malang.
Keywords: Legal Politics, Regulation of the Minister of Law and Human Rights of the Republic of Indonesia Number 10 of 2020, Recidivist
PERALIHAN HAK ATAS TANAH DENGAN PERJANJIAN PENGIKATAN JUAL BELI BERDASARKAN SEMA NO. 4 TAHUN 2016
Authors: Rochmah Zulfika , Solehoddin Solehoddin , Miladiyanto Sulthon 
Published: June 2023

The transfer of land rights through buying and selling according to PP No. 24 of 1997 concerning land registration states that land can be transferred if there is a Sale and Purchase Deed (AJB) made by PPAT, the development of legal facts is that there is a Sale and Purchase Binding Agreement (PPJB) based on SEMA Number 4 of 2016 that the transfer of land rights can only be transferred based on PPJB, because until now there has been no clear regulation specifically regarding PPJB in the laws and regulations, it is often questioned regarding the validity of PPJB, as well as legal protection to the parties who make it. The purpose of this study was to analyze the status of the transfer of land rights with PPJB based on SEMA No. 4 of 2016 which does not require the existence of AJB and to know the legal protection for the parties if the transfer of land rights is only with PPJB only. This study uses a normative juridical research method with an approach in the form of legislation and cases with qualitative descriptive analysis methods. The results of this study are that the status of the transfer of land rights with PPJB based on SEMA No. 4 of 2016 which does not require the existence of AJB is valid as Article 1338 of the Civil Code but does not guarantee that the transfer of land rights to other people can occur if the transfer is not carried out according to Article 1459 of the Civil Code, PPJB before AJB is allowed as long as the requirements as stipulated in the regulations are met, Meanwhile legal protection for parties who make PPJB only in the transfer of land rights is preventive legal protection, by pouring clear clauses in PPJB and repressive legal protection, the parties can resolve it until the court.
Keywords: Transfer of rights, PPJB, Legal Protection
Splenic infarction in massive splenomegaly secondary to chronic myeloid leukemia.
Authors: Avilez Arias JM , Cabrera Valdéz JH , Garibay Alvarez J , Esquer García MF , Burgos Borbón DH , Acosta García KA 
Published: June 2023

Resumen

Introducción: Las enfermedades que ocasionan esplenomegalia, incrementan el riesgo de infarto esplénico. Las dos principales causas de infarto esplénico, son las enfermedades tromboembólicos, y las enfermedades hematológicos infiltrativas.

Caso clínico: Femenino de 35 años de edad, con diagnóstico de Leucemia mieloide crónica, ingresa al servicio de urgencias por dolor abdominal de inicio súbito, se documenta en estudio tomográfico esplenomegalia masiva, y zona de infarto esplénico en polo superior, cursa durante estancia intrahospitalaria sin mejoría clínica a pesar de tratamiento médico, tras deterioro clínico, y de estado hemodinámico se decide realizar esplenectomía de emergencia.

Discusión:Las manifestaciones clínicas de infarto esplénico son variables, por lo que resultan útiles estudio de imagen, dentro de sus complicaciones puede agregarse la presencia de absceso como en el presente caso, al añadirse este tipo de entidades puede requerirse evento quirúrgico de urgencia.

Conclusión: Identificar pacientes con enfermedades hematológicas, con manifestaciones a nivel esplénico que pueden traducirse como esplenomegalia o esplenomegalia masiva, y sus posibles complicaciones como resulta el infarto esplénico, permitirá orientar el abordaje diagnóstico en el escenario de dolor abdominal.
Business Responses Towards Corporate Social Responsibility and Sustainable Development Goals During Covid-19 Pandemic
Authors: Madaan Geetika , Kaur Maninder , Gowda Kavitha R , Gujrati Rashmi , Uygun Hayri 
Published: June 2023

Objective: In India, incorporating structural transformation in corporate social responsibility for achieving sustainable development goals in the Covid-19 Pandemic has become a priority. Therefore, the present article aims to review the corporate social responsibility activities conducted by Nine Indian companies (two public sector organizations and seven private sector organizations) towards attaining Sustainable Development Goals in times of global pandemic.

To explore CSR activities performed by the Indian companies (both public and private) in recent times of crisis of covid-19.
To assess the impact of Covid-19 on the economic, social, and technological environment of Indian Companies in recent times.

Method: For our research, we chose India since it was one of the earliest and worst-hit countries during the recent pandemic. Even though huge Asian corporations are a minority, It is a good fit for our study goal for various reasons. Less and medium-sized businesses, on the other hand, have a far smaller influence on society, Due to their prominence in the press, clients or consumers are more likely to provide feedback if they are proactive. As a second point, major companies have greater resources (e.g., human and financial) to spend on reporting and distributing social and environmental information. The existing study applied bibliometric analysis in the exploratory research. The data collection done through secondary sources in which articles extracted with the use of PRISMA flowchart.

Result: The study's findings state that most selected Indian Companies spend Rupees 50-1000 crores as corporate social responsibility activities and contribute to the Pradhan Mantri Relief Fund as a business response to face challenges in times of pandemic. Moreover, private companies spend more on CSR activities than public companies in India. The study provides suggestions to the government to make the corporate social responsibility activities compulsory for all the profitable companies so that country can maintain a corporate pool of contingent funds that can utilize to meet such times of critical circumstances.

Conclusion: Companies are taking steps to ensure the safety and protection of their personnel. This has been reflected in corporate social responsibility initiatives as well. Corporate social responsibility efforts must include pushing for and facilitating access to health insurance programmes and other equity indicators as a result.