bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ad-Hoc Monitoring of COVID-19 Global Research Trends for Well-Informed Policy Making
Authors: Sarkar Souvika , Bijoy Biddut Sarker , Saba Syeda Jannatus , Feng Dongji , Mahajan Yash , Amin Mohammad Ruhul , Islam Sheikh Rabiul , Karmaker (“Santu”) Shubhra Kanti 
Published: December 2022

The COVID-19 pandemic has affected millions of people worldwide with severe health, economic, social, and political implications. Healthcare Policy Makers (HPMs) and medical experts are at the core of responding to this continuously evolving pandemic situation and are working hard to contain the spread and severity of this relatively unknown virus. Biomedical researchers are continually discovering new information about this virus and communicating the findings through scientific articles. As such, it is crucial for HPMs and funding agencies to monitor the COVID-19 research trend globally on a regular basis. However, given the influx of biomedical research articles, monitoring COVID-19 research trends has become more challenging than ever, especially when HPMs want on-demand guided search techniques with a set of topics of interest in mind. Unfortunately, existing topic trend modeling techniques are unable to serve this purpose as (1) traditional topic models are unsupervised, and (2) HPMs in different regions may have different topics of interest that they want to track. To address this problem, we introduce a novel computational task in this article calledAd-Hoc Topic Tracking, which is essentially a combination ofzero-shottopic categorization and the spatio-temporal analysis task. We then propose multiplezero-shotclassification methods to solve this task by building on state-of-the-art language understanding techniques. Next, we picked the best-performing method based on its accuracy on a separate validation dataset and then applied it to a corpus of recent biomedical research articles to track COVID-19 research endeavors across the globe using a spatio-temporal analysis. A demo website has also been developed for HPMs to create custom spatio-temporal visualizations of COVID-19 research trends. The research outcomes demonstrate that the proposedzero-shotclassification methods can potentially facilitate further research on this important subject matter. At the same time, the spatio-temporal visualization tool will greatly assist HPMs and funding agencies in making well-informed policy decisions for advancing scientific research efforts.
Symmetric longitudinal Mach-Zehnder modulator using lithium niobate
Authors: Hbeeb Sadeq Adnan , Abdullah Ahmad S. , Alshamary Haider Ali Jasim 
Published: December 2022

There are many problems that restrict the work of the Mach-Zehnder modulator (MZM), including the lack of using various windows of wavelengths, the large half-wave voltage, and the small optical confinement factor. In this paper, a mathematical model for MZM based on lithium niobate (LN) is designed to solve these problems. In this model, a wide window of optical wavelength from visible-to-infrared (632.8-to-1560 nm) was utilized. Moreover, it achieved a better modulation with lower attenuation and a lower dispersion by the window (1550-1560) nm. The other window of optical wavelength is about (632.8-to-634 nm), and (646-to-647 nm) which can be used for short-haul applications to reduce attenuation and dispersion. Furthermore, a small length of the arm, about 2-3 mm, was utilized to accomplish a large change of the refractive index and lower applied voltage of up to 250 V. The small operation half-wave voltage achieved about 1.2 V leading to better switching of the MZM. In addition, a large optical confinement factor of ≤1 unitless was obtained. Even better performance of MZM was attained by using a suitable length arm of MZM of about 2 mm, along with an electric field of about 175 V/mm and 233 V/mm using poling at 100 V.
Os impasses ao acesso à intersubjetividade: observações clínicas de um bebê com risco de evolução autística
Authors: Saboia Camila 
Published: December 2022

O artigo aborda os impasses vividos por um bebê com risco de autismo em seu processo de subjetivação. Estudos afirmam que há bebês que, muito precocemente, recusam-se a estabelecer trocas com o objeto materno, impossibilitando que a mãe entre em um estado de identificação com seu bebê, o que colocaria em pauta que o autismo infantil não se limitaria apenas a uma falha materna, mas se trataria de uma patologia multifatorial. Quais intervenções clínicas seriam necessárias para que a mãe e o bebê possam juntos (re)escrever uma nova narrativa psíquica? Haveria um tipo de intervenção e de manejo clínico específico nos casos de bebês com risco de autismo? E como a psicanálise contemporânea, fundamentada pela leitura da intersubjetividade, nos ajudaria na compreensão da clínica da intervenção precoce?
Écrire-rêver le rapport à la pratique professionnelle d’un coordonnateur d’ULIS collège : la répétition d’une réalité inrêvée
Authors: Markakis Konstantinos 
Published: December 2022

Pour ma recherche doctorale, j’ai exploré le rapport de certains coordonnateurs d’ULIS collège (unité localisée pour l’inclusion scolaire) à leurs propres pratiques professionnelles en France. Dans le cadre du projet nationale pour une école inclusive, les coordonnateurs d’ULIS sont des enseignants spécialisés qui proposent un enseignement adapté auprès des élèves reconnus en situation de handicap et mettent en œuvre le PPS (projet personnalisé de scolarisation), conçu pour chacun d’entre eux, en collaboration étroite avec les autres enseignants et acteurs du médico-social. À partir d’une approche clinique d'orientation psychanalytique en sciences de l’éducation et de la formation, j’ai souhaité explorer comment les enseignants spécialisés occupant cette fonction complexe vivaient leur métier sur le plan psychique. Dans cette perspective, j’ai mené des entretiens cliniques de recherche avec quatre professionnels. Ici, j’expose le dispositif d’analyse des entretiens mis en place dans l’après-coup et la place particulière de l’écriture comme une modalité d’élaboration psychique. Inspiré des travaux de T. Ogden (1994, 2005), le terme « écrire-rêver » désigne la rêverie sous-tendant le processus d’écriture dans ce dispositif, qui permet la représentabilité du lien interviewer-interviewé en rapport avec la pratique professionnelle. Pour illustrer ce propos, je présente l’analyse d’un seul entretien avec un coordonnateur, en restituant le chemin qui m’a amené à l'hypothèse de l’actualisation d’une réalité « inrêvée » (Ogden, 2005) dans l’entretien en rapport avec son lien aux autres enseignants du collège.
L’arte come struttura pensante e generatrice di nuovi mondi
Authors: Ponzio Luciano 
Published: December 2022

Da angolature prospettiche diverse, letteraria, poetica, cinematografica, i corpora teorici di Jurij Lotman tracciano una strada comune, rivolta fin dall’inizio allo studio di quei linguaggi che caratterizzano l’essere umano come animale semiotico, ovvero i testi artistici capaci di raffigurazione [izobraženie]. Si tratta della caratterizzazione specifica di un testo che vuole assurgere a testo artistico, modellato in senso semiotico sulla base della funzione che esso svolge in una cultura e del riconoscimento che questa gli assegna come appartenete ad un genere testuale. L’approccio lotmaniano di tipo “culturologico” amplia e specifica la nozione di testo che da struttura sincronica chiusa assurge a “testo culturale” con la sua specifica funzione creativa/estetica/poetica, con il suo valore etico e sociale, con i suoi legami con la realtà nella sua dimensione cronotopica.
Tali studi hanno assegnato una speciale centralità ai testi artistici, ai “generi di discorso secondari” (qui nell’accezione bachtiniana riferita ai generi letterari). Ciò ha reso possibile, di riflesso, l’assunzione del testo artistico e dei suoi specifici linguaggi quale modello e strumento essenziali per lo studio/comprensione della Cultura, per sua natura dinamica e eterogenea, tanto da non lasciarsi facilmente descrivere, da non rendersi riducibile a modelli caratterizzati dalla codificazione-decodificazione, a farsi uniformare/unificare, situare dentro un sistema (quale la langue), presentandosi invece, come un insieme di pratiche sociali.
Ciò permette di riconoscere/ristabilire l’importanza vitale che ha, per il rinnovamento del “reale”, la visione artistica con le sue rifrazioni estetiche intersemiotiche. E ciò sia come risultato dell’interrelazione tra scrittura e immagini del mondo, sia anche tramite una particolare lente meta-semiosica, con l’assumersi la responsabilità del mantenimento della vita stessa dei segni in una prospettiva semioetica, dimostrandoci come Lotman possa essere considerato attualmente tra gli autori in campo semiotico più creativi e anche specificamente “modellizzatori”, costruttori, innovatori nei confronti del “reale”.
Massive post-infarction ventricular septal rupture complicaing cardiogenic shock with long term veno-arterial extracorporeal membrane oxygenation support
Authors: Wang Wei , Feng Ying , Lin Xin , Wu Xiangyang , Chen Gang , Ma Ruchao , Guan Xinqiang 
Published: December 2022

Introduction Ventricular septal rupture (VSR) following acute myocardial infarction (AMI) is a rare but serious complication often causing cardiogenic shock (CS). The timing of surgery is a difficult problem for surgeons because of high mortality and surgical complexity. We present a case of successful use of extracorporeal membrane oxygenation (ECMO) for maintaining haemodynamic stability preoperative and delaying surgical repair of VSR patient in severe CS. Case report A 57-year-old man with AMI complicated by severe CS due to an massive VSR. Emergency surgery was considered a too high mortality risk. The patient was implanted with a percutaneous veno-arterial ECMO (VA-ECMO) system as a bridge to surgery for stabilizing general condition. On the 31th day after ECMO implantation, the ventricular septal defect was successfully repaired and weaning from the ECMO. Discussion This case study illustrates that it may be considered to use long term ECMO preoperative to delayed surgery which leads to higher survival in cases of massive VSR patient after AMI in hemodynamically compromised patients. Still the optimal duration of mechanical circulatory support and the optimal timing for surgery need more research to define. Conclusion This case indicates the feasibility of preoperative using of a long term VA-ECMO as a bridge to surgical repair of VSR patient after AMI in severe CS. The optimal duration of mechanical circulatory support and the optimal timing for surgery still require further investigation.
Association between FLT3-ITD and additional chromosomal abnormalities in the prognosis of acute promyelocytic leukemia
Authors: Vu Minh Phuong , Nguyen Cuc Nhung , Vu Hoang , Nguyen Tuyet Mai , Nguyen Tuan Tung , Pham Phuong Thao 
Published: December 2022

Objectives Internal tandem duplications of the Fms-like tyrosine kinase 3 gene ( FLT3-ITD) and additional chromosomal abnormalities (ACA) are prognostic factors in patients with acute promyelocytic leukemia (APL). This study aimed to determine the effect of the association between FLT3-ITD and ACA in the prognosis of APL. Methods This was a retrospective cohort study including 60 patients with APL treated with all-trans retinoic acid (ATRA) and chemotherapy. Five-year overall survival (OS) and progression-free survival (PFS) were analyzed in patient groups according to the presence of FLT3-ITD and ACA. Results FLT3-ITD was an independent adverse factor for 5-year PFS, and ACA was an independent adverse factor for 5-year OS. There were significant differences in OS and PFS among the groups: FLT3-ITD-negative without ACA, FLT3-ITD-positive without ACA, FLT3-ITD-negative with ACA, and FLT3-ITD-positive with ACA. The OS times were 52.917, 45.813, 25.375, and 23.417 months, and the PFS times were 48.833, 38.563, 23.250, and 17.333 months, respectively. Conclusion FLT3-ITD and ACA are associated with the poorest OS and PFS outcomes in patients with APL treated with chemotherapy plus ATRA.
Influence of extrusion parameters on filled polyphenylsulfone tufting yarns on open-hole tensile strength
Authors: McGarrigle Cormac , Wegrzyn Marcin , Han Yisong , McIlhagger Alistair , Harkin-Jones Eileen , Archer Edward 
Published: December 2022

Tufting has been shown to improve the mechanical properties of composites. Unlike other published works which rely on commercially available materials, for this study, continuous polymer yarns with diameters ranging from 160 μm to 720 μm of unfilled PPSU and PPSU nanocomposites with 1 wt.% of carbon nanotubes (CNT) were prepared using a twin-screw extruder. The tensile properties of these yarns generally improved with the addition of CNT at higher values of ‘screw speed to haul-off’ ratio. This effect is correlated with the yarn draw down ratio and attributed to the nanofiller orientation induced in the thermoplastic matrix. The fibres exhibited as much as a 23% increase in Ultimate Tensile Strength (UTS) for the same parameter set when loaded with CNT. Depending on filler and processing parameters set, yarns varied in UTS from 96.4 MPa to 206.2 MPa for unfilled PPSU and PPSU-CNT, respectively.
Development of PP/EPDM thermoplastic elastomer by doped with 2-hydroxypropyl- 3-piperazinyl-quinoline carboxylic acid methacrylate based neusilin® for sanitary applications
Authors: Songprasob Suphitcha , Wimolmala Ekachai , Taptim Kulnida , Sombatsompop Narongrit 
Published: December 2022

The effect of the addition of 2-Hydroxypropyl-3-Piperazinyl-Quinoline carboxylic acid Methacrylate (HPQM) in Neusilin® into thermoplastic vulcanizates (TPV) Polypropylene/ethylene propylene diene monomer (PP/EPDM) type on the mechanical and antibacterial properties were studied. Ethylene propylene diene monomer compounds were mixed with Zinc dimethacrylate (ZDMA), Dicumyl peroxide (DCP), and paraffin oil by a two-roll mill machine. Polypropylene and HPQM in Neusilin® were extruded by varies HPQM content 0, 1250, 2500, 3750 and 5000 ppm. Polypropylene added antibacterial agent and EPDM compounds were mixed by twin-screw extruded weight ratios of 100:0, 75:25, 50:50, and 25:75 w/w with varied screw speeds of 60, 80, and 100 r/min. Polypropylene/Ethylene propylene diene monomer compounds were produced by compression moulding to form specimens. The mechanical properties were tested by tensile test and hardness test. It was found that screw speed did not affect the mechanical properties. Disk diffusion test and plate count agar (PCA) method were used for antibacterial properties. For both methods, the specimens contained an antibacterial agent against Escherichia coli ( E. coli ATCC 25922) and Staphylococcus aureus ( S. aureus ATCC 25923). The result of the disk diffusion test suggests that the more HPQM in Neusilin® content, the more the inhibition radius of only E. Coli bacteria. Plate count agar method proceeded by varying the contact time at 0, 1, 2, 3 and 4 h. Viable cell counts of E. coli decreased significantly at HPQM content 2500 ppm, while the viable cell count of S. aureus remained unchanged at 3750 ppm. Moreover, the rubber ingredients in EPDM, which are DCP and ZDMA, affect the release of antibacterial agents by hydrophobic characteristics and compatible conditions.
Patient-reported disease impact of systemic lupus erythematosus with active joint symptoms: Results from the systemic lupus erythematosus-update survey
Authors: Kamen Diane L , Birt Julie A , Hadi Monica A , Gibbons Elizabeth , Bushnell Donald M , Yu Ren , Delbecque Laure A , Griffing Kirstin , Askanase Anca 
Published: December 2022

Background Many people with systemic lupus erythematosus (SLE) experience joint pain, swelling, and stiffness. These joint symptoms are associated with problems in physical functioning and work disability. We used survey data from adults with SLE to explore the burden and impact of joint symptoms. Methods SLE-UPDATE was a 2019 cross-sectional US survey of adults with SLE. We compared respondents with “currently active” joint symptoms’ and those “without currently active” joint symptoms. The active joint cohort comprised survey respondents who self-reported current “stiffness in joints” or “pain/swelling in joints” and who had moderate to severe joint pain (Worst Joint Pain Numeric Rating Scale [NRS] score ≥ 4). Respondents not fulfilling these criteria were included in the non-active joint cohort. Outcomes included frequency and severity of pain, patient-reported outcomes (LupusPRO™ and Work Productivity and Activity Impairment: Lupus [WPAI-Lupus]), satisfaction with current treatments, and importance of different treatment goals. Results More respondents in the active joint cohort (N = 285) than in the non-active joint cohort (N = 215) reported pain most or all the time over the preceding 7 days (77.5% vs. 32.1%, p < .0001), fibromyalgia (45% vs. 12%, p < .0001), and higher (worse) mean scores on the Worst Pain NRS (6.5 vs. 4.8, p < .0001) and Worst Joint Pain NRS (6.7 vs. 4.5, p < .0001). Mean Lupus PRO health-related quality of life (HRQoL) total score was lower (worse) in the active joint cohort (48.9 vs. 64.1, p < .0001). WPAI-Lupus scores indicated greater work productivity losses and activity impairment in the active joint cohort. More respondents in the active joint cohort than in the non-active joint cohort were neutral or not satisfied with current treatments and rated reducing pain as a “very important” treatment goal (26.7% vs. 18.1%). Conclusions Respondents with SLE and active joint manifestations in addition to having more pain report lower HRQoL and were less satisfied with their current treatments. Comorbid fibromyalgia may play a role in joint symptoms in patient with SLE joint manifestations. There is an unmet need for new therapeutic options to reduce joint symptom burden among patients with SLE.
“It's cancer screening after all”. Barriers to cervical and colorectal cancer screening and attitudes to promotion of self-sampling kits upon attendance for breast cancer screening
Authors: Kirkegaard Pia , Larsen Mette Bach , Andersen Berit 
Published: December 2022

Objectives To explore barriers to cervical and colorectal cancer screening and attitudes to promotion of self-sampling kits upon attendance for breast cancer screening. Methods Interview study with women who had not responded to one or more invitations to cervical or colorectal cancer screening. A semi-structured interview guide was used and interviews were audio recorded and transcribed verbatim. Concepts from Temporal Motivation Theory were used to structure and analyse the data. Results Twenty-two women were interviewed. Screening was highly valued but the women perceived screening for cervical cancer and colorectal cancer as more troublesome to participate in, compared with participation in breast cancer screening. The lack of a pre-booked appointment or a suggested deadline attenuated the perceived value of cervical and colorectal cancer screening and this further increased procrastination. Promotion of self-sampling kits for cervical and colorectal cancer screening upon attendance for breast cancer screening was considered a feasible way to increase salience of both types of screening. Conclusion A high number of micro steps and absence of a deadline in cervical and colorectal cancer screening diverted attention away from screening participation in cervical and colorectal cancer screening. The main facilitator could be reduction of micro actions, proposing a suggested deadline, and promotion of self-sampling kits when attending breast cancer screening to increase salience and a renewed attention to all three screening programmes.
Pediatric Orthognathic Surgery: A NSQIP-P Comparison of Peri-Operative Factors and Outcome Differences Between Cleft and Noncleft Patients
Authors: Zeyl Victoria G. , Lopez Christopher D. , Yoon Joshua , Rivera Perla Krissia M. , Shakoori Pasha , Girard Alisa O. , Hopkins Elizabeth , Redett Richard J. , Yang Robin S. 
Published: December 2022

Objective The present study aimed to investigate the risk factors, complication profiles, and clinical outcomes of cleft and noncleft patients undergoing single jaw (mandibular or LeFort 1) and bimaxillary (BSSO + LeFort 1). Design Retrospective Cross-sectional Study Setting: National Surgical Quality Improvement Program database 2018–2019 Patients Pediatric patients Interventions Outcomes for mandibular, LeFort 1, and bimaxillary osteotomy were retrospectively evaluated for cleft and noncleft patients. Main Outcome Measures Multivariate logistic regression was used to determine the odds of complications and length of stay for cleft and noncleft patients undergoing single jaw and double jaw surgery. Results 669 pediatric patient underwent orthognathic surgery in the study period; the majority received LF1 only (n = 385; 58.3%), followed by mandible only (n = 179; 27.1%), and bimaxillary (n = 105; 15.9%%). Cleft differences were present in 56% of LFI patients, 32% of mandibular patients, and 22% of bimaxillary patients. After multivariate adjustment, ASA class III was associated with nearly 400% increased odds of any complication including readmission and reoperation (OR = 5.99; CI [[1.54−23.32]], p < 0.01, and 65% increased LOS (β-coefficient = 1.65, CI [1.37−1.99], p < 0.01). Presence of cleft was not significantly associated with odds of any complication (p = 0.69) nor increased LOS (p = 0.46) in this population. Conclusion Complications remained low between surgery types among cleft and noncleft patients. The most significant risk factor in pediatric orthognathic surgery was not the presence of cleft but rather increased ASA class. Though common in patients seeking orthognathic surgery, cleft differences did not cause additional risk after adjustment for other variables.
The Effect of the Drug-Related Problems Prevention Bundle on Early Readmissions in Patients From the Emergency Department: A Randomized Clinical Trial
Authors: Juanes Ana , Ruíz Jesús , Puig Mireia , Blázquez Marta , Gilabert Antoni , López Laia , Baena M. Isabel , Guiu Josep M. , Antònia Mangues Maria 
Published: December 2022

Background: Drug-related problems (DRPs) are prevalent and avoidable disease that patients experience due to drug use or nonuse. However, secondary prevention policies have not yet been systematized. Objective: To assess the clinical impact of a secondary prevention bundle for DRPs in patients who visited the emergency department (ED) for medicine-related problems. Methods: A single-center randomized clinical trial was conducted from August 28, 2019, to January 28, 2021, with 1-month follow-up. We included 769 adult patients who visited ED with a DRP associated with cardiovascular, alimentary tract, and metabolic system medications. For the intervention group, a DRP prevention bundle, consisting of a combined strategy initiated in the ED was applied. Patients in the control group received standard pharmaceutical care. Intervention was evaluated in terms of 30-day hospital readmission due to any cause. Results: Final analysis included 769 patients, of which 68 (8.8%) were readmitted within 30 days (control group, 40 of 386 [cumulative incidence: 10.4%]; intervention group, 28 of 383 [cumulative incidence, 7.3%]). After adjustment of the model for chronic heart failure, there was a lower incidence of hospital readmission among patients in the intervention group compared with those in the control group, odds ratio: 0.59 [95% confidence interval: 0.37-0.97]; number needed to treat (NNT) = 32. No significant differences in other outcomes were observed. Conclusion and Relevance: In this clinical trial, DRP prevention bundle in adjusted analysis decreased the rate of 30-day hospital readmission for any cause in patients who visited ED for a DRP. Trial registration: ClinicalTrials.gov (Identifier: NCT03607097)