bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neurological telerehabilitation in the COVID-19 era – current perspectives through a bibliometric analysis
Authors: Lebioda Lúcia Aparecida , Pedroso Bruno , Santos Marlon Estevam Camilo dos , Pinto Guilherme Moreira Caetano , Welling Leonardo Christiaan 
Published: September 2023

ObjectiveTo identify bibliometric parameters and research trends regarding to telerehabilitation of patients with stroke in the COVID-19 era.MethodologyThis is an integrative review carried out in the Scopus database, from June to July 2021, through the Biblioshiny graphical interface, provided by the Bibliometrix program. The search terms used were “Stroke,” “COVID-19” and “Telerehabilitation.” Results were filtered by publication date from 2019 onwards. No language restrictions were imposed.ResultsTwenty two articles were included in the study and the results were presented in the form of figures demonstrating that the journal Frontiers in Neurology was the one with the most relevant studies and the author with the highest number of citations. The Brazilian Academy of Neurology was the institution with the greatest number of studies and China ranked first as the country with the greatest scientific production. The authors used recent references in their work. A thematic map showed the centrality and density of the words presented and, finally, a three-field graph showed a strong intimacy between countries, keywords and authors.ConclusionA greater interest in the subject was observed in China with greater relevance of journals and institutions focused on neurology. However, despite telerehabilitation being an effective alternative in the context of the pandemic, few studies have explored this modality.
Impact of home-based training and nutritional behavior on body composition and metabolic markers in cancer patients: data from the CRBP-TS study
Authors: Darmochwal Sophia , Bischoff Christian , Thieme René , Gockel Ines , Tegtbur Uwe , Hillemanns Peter , Schulze Antina , Voss Johannes , Falz Roberto , Busse Martin 
Published: September 2023

IntroductionObesity and physical inactivity are known to affect cancer's development and prognosis. In this context, physical aerobic and resistance training as well as a Mediterranean nutrition have been proven to have many positive health effects. The aim of this study was therefore to investigate the effect of home-based training on body composition and certain metabolic laboratory parameters.MethodsPatients with breast, colorectal and prostate cancer who underwent curative surgery at stages T1N0M0–T3N3M0 were eligible for this trial and randomized to an intervention and control group. In the intervention group the patients carried out online-based strength-endurance home training during the 6-month study period. Body composition was assessed via bioelectrical impedance analysis (baseline, 3 months and 6 months). Metabolic blood parameters were also analyzed and nutrition behavior determined using the Mediterranean Diet Adherence Screener (MEDAS).ResultsThe intervention group's fat mass decreased while their lean body mass increased (time effect p = 0.001 and p = 0.001, respectively). We found no interaction effect in body weight (p = 0.19), fat mass [p = 0.06, 6-months estimates −0.9 (95% CI −1.8 to −0.1)] and lean body mass (p = 0.92). Blood samples also failed to show a statistically significant interaction effect between time × group for HbA1c% (p = 0.64), Insulin (p = 0.33), Adiponectin (p = 0.87), Leptin (p = 0.52) and Triglycerides (p = 0.43). Only Adiponectin revealed significance in the time effect (p &lt; 0.001) and Leptin in the group effect (p = 0.03). Dietary behavior during the study period was similar in patients in the intervention and control groups (interaction p = 0.81; group p = 0.09 and time p = 0.03).DiscussionIndividualized online-based home training in postoperative cancer patients revealed only minor changes, with no group differences in body composition or metabolic laboratory parameters, which were predominantly in the reference range at baseline. More studies investigating effects of online-based home training on body composition and nutrition behavior are needed.Trial registrationhttps://drks.de/search/en/trial/DRKS00020499, DRKS-ID: DRKS00020499.
ctDNA-based detection of molecular residual disease in stage I-III non-small cell lung cancer patients treated with definitive radiotherapy
Authors: Lebow Emily S. , Shaverdian Narek , Eichholz Jordan E. , Kratochvil Leah B. , McCune Megan , Murciano-Goroff Yonina R. , Jee Justin , Eng Juliana , Chaft Jamie E. , Kris Mark G. , Kalashnikova Ekaterina , Feeney Jordan , Scalise Carly Bess , Sudhaman Sumedha , Palsuledesai Charuta C. , Malhotra Meenakshi , Krainock Michael , Sethi Himanshu , Aleshin Alexey , Liu Minetta C. , Shepherd Annemarie F. , Wu Abraham J. , Simone Charles B. , Gelblum Daphna Y. , Johnson Kaylie A. , Rudin Charles M. , Gomez Daniel R. , Razavi Pedram , Reis-Filho Jorge S. , Isbell James M. , Li Bob T. , Rimner Andreas 
Published: September 2023

BackgroundSensitive and reliable biomarkers for early detection of recurrence are needed to improve post-definitive radiation risk stratification, disease management, and outcomes for patients with unresectable early-stage or locally advanced non-small cell lung cancer (NSCLC) who are treated with definitive radiation therapy (RT). This prospective, multistate single-center, cohort study investigated the association of circulating tumor DNA (ctDNA) status with recurrence in patients with unresectable stage I-III NSCLC who underwent definitive RT.MethodsA total of 70 serial plasma samples from 17 NSCLC patients were collected before, during, and after treatment. A personalized, tumor-informed ctDNA assay was used to track a set of up to 16 somatic, single nucleotide variants in the associated patient’s plasma samples.ResultsPre-treatment ctDNA detection rate was 82% (14/17) and varied based on histology and stage. ctDNA was detected in 35% (6/17) of patients at the first post-RT timepoint (median of 1.66 months following the completion of RT), all of whom subsequently developed clinical progression. At this first post-RT time point, patients with ctDNA-positivity had significantly worse progression-free survival (PFS) [hazard ratio (HR): 24.2, p=0.004], and ctDNA-positivity was the only significant prognostic factor associated with PFS (HR: 13.4, p=0.02) in a multivariate analysis. All patients who developed clinical recurrence had detectable ctDNA with an average lead time over radiographic progression of 5.4 months, and post-RT ctDNA positivity was significantly associated with poor PFS (p&lt;0.0001).ConclusionPersonalized, longitudinal ctDNA monitoring can detect recurrence early in patients with unresectable NSCLC patients undergoing curative radiation and potentially risk-stratify patients who might benefit most from treatment intensification.
A genetic study of a Brazilian cohort of patients with X-linked hypophosphatemia reveals no correlation between genotype and phenotype
Authors: Borghi Mauro , Silva Leopoldo Muniz da , Bispo Luciana , Longui Carlos A. 
Published: September 2023

AimX-linked hypophosphatemia (XLH) is the most common inherited form of rickets, and it is caused by pathogenic inactivating variants of the phosphate-regulating endopeptidase homolog X-linked (PHEX) gene. The main purpose of this study is to identify the presence of a genotype–phenotype correlation in a cohort of XLH patients.MethodsThis is a retrospective study including patients diagnosed with hypophosphatemic rickets, confirmed by clinical, radiological, and laboratory findings. Medical records were reviewed for phenotypic analyses. Genomic DNA was extracted from the peripheral blood lymphocytes, and PHEX sequencing was performed by exomic NGS sequencing. The Wilcoxon rank-sum test and the two-tailed Fisher's exact test were employed for the statistical analyses of this study.ResultsA total of 41 patients were included in this study, and 63.41% (26/41) of the patients were female. The mutation analyses identified 29.27% missense variants and 29.72% nonsense variants, most of them were considered deleterious (66.41%). Six novel deleterious variants in the PHEX gene were detected in seven patients. The median concentrations of pretreatment serum calcium, phosphorus, and parathyroid hormone (PTH) were not significantly different among patients with different genotypes. An orthopedic surgery due to bone deformity was required in 57.69%.ConclusionsOur analysis did not identify any specific genotype as a predictor. No significant genotype–phenotype correlation was found, suggesting that the recognition of subjacent pathogenic mutation in the PHEX gene may have limited prognostic value. Despite this finding, genetic testing may be useful for identifying affected individuals early and providing appropriate treatment.
Fumigant activity and transcriptomic analysis of two plant essential oils against the tea green leafhopper, Empoasca onukii Matsuda
Authors: Tan Weiwen , Zhang Ni , Wang Jinqiu , Pu Tianyi , Hu Jifeng , Li Can , Song Yuehua 
Published: September 2023

Introduction: The tea green leafhopper, Empoasca (Matsumurasca) onukii Matsuda, R., 1952 (Hemiptera: Cicadellidae), is currently one of the most devastating pests in the Chinese tea industry. The long-term use of chemical pesticides has a negative impact on human health, impeding the healthy and sustainable development of the tea industry in this region. Therefore, there is a need for non-chemical insecticides to control E. onukii in tea plants. The essential oils from plants have been identified for their potential insecticidal ability; however, there is a lack of knowledge regarding the effect of plant essential oils on E. onukii and its gene expression.Methods: In order to address these knowledge gaps, the components of Pogostemon cablin and Cinnamomum camphora essential oils were analyzed in the present study using gas chromatography‐mass spectrometry. The fumigation toxicity of two essential oils on E. onukii was tested using sealed conical flasks. In addition, We performed comparative transcriptome analyses of E. onukii treated with or without P. cablin essential oil.Results: The 36-h lethal concentration (LC50) values for E. onukii treated with P. cablin and C. camphora essential oils were 0.474 and 1.204 μL mL−1 respectively. Both essential oils exhibited the potential to control E. onukii, but the fumigation activity of P. cablin essential oil was more effective. A total of 2,309 differentially expressed genes were obtained by transcriptome sequencing of E. onukii treated with P. cablin essential oil.Conclusion: Many of differentially expressed genes were found to contain detoxifification genes, indicating that these families may have played an important role when E. onukii was exposed to essential oil stress. We also found differential expression of genes related to redox-related gene families, suggesting the upregulation of genes associated with possible development of drug and stress resistance. This work offers new insights for the prevention and management of E. onukii in the future.
Psychopathological factors and personality dimensions on dysfunctional eating behaviors in a sample of individuals with obesity
Authors: Attanasio Margherita , Giuliani Antonio , Romano Lucia , Laidò Cristina , Di Poggiovalle Gilda , Le Donne Ilenia , Di Fonzo Valentina , Tiberti Sergio , Valenti Marco , Mazza Monica 
Published: September 2023

IntroductionObesity and eating disorders are considered to be part of a broad spectrum of disorders associated with weight issues and maladaptive eating styles. Several studies show that psychopathological and personality characteristics contribute to the development and maintenance of obesity and dysfunctional eating behaviors, showing a bidirectional relationship. The purpose of this study was to understand the role of psychopathological factors and personality dimensions on dysfunctional eating behaviors in a sample of individuals with obesity.MethodsThe study was conducted with 96 individuals with obesity (31 males and 65 females) who underwent psychological assessment. The instruments administered included the Cognitive Behavioral Assessment 2.0 - Primary Scales, the Minnesota Multiphasic Personality Inventory-2, and the Eating Disorder Inventory. Relationships between dysfunctional eating behaviors and personality and psychopathological factors were explored through mediation analysis.Results and discussionOur results showed that difficulties related to impulse control and behavior, along with negative and dysphoric emotions, may be associated with difficulties in eating behavior. Mediation analysis showed that the combination of depressive and obsessive-compulsive symptomatology may exacerbate or contribute to the occurrence of eating disorders. These psychopathological aspects should be taken into account during the assessment of patients who decide to undergo bariatric surgery and should be targets of specific psychological interventions.
The association between socioeconomic status and health-related quality of life among young and middle-aged maintenance hemodialysis patients: multiple mediation modeling
Authors: Mai Qingxin , Xu Siyi , Hu Jingyi , Sun Xiaoming , Chen Gangyi , Ma Zhen , Song Yang , Wang Chao 
Published: September 2023

ObjectiveTo explore the relationship between socioeconomic status (SES), illness perception, social functioning, and health-related quality of life (HRQoL) of young and middle-aged maintenance hemodialysis (MHD) patients and the internal mechanism of action.DesignA multicenter cross-sectional study.MethodsAn aggregate of 332 young and middle-aged MHD patients were enrolled from hemodialysis centers in four general hospitals in Guangzhou, Guangdong, China, from June to December 2022. The questionnaires used included one for general demographic data, the Brief Illness Perception Questionnaire (BIPQ), Social Dysfunction Screening Scale (SDSS), and the 12-item Short Form Health Survey (SF-12).ResultsBoth SES and HRQoL were negatively correlated with illness perception and social functioning, respectively. SES was positively correlated with HRQoL. Illness perception was positively correlated with social functioning. The indirect effects of illness perception and social functioning on the relationship between SES and HRQoL were 0.33 and 0.31, making up 41.06% and 38.91% of the sum. The chain indirect effect of illness perception and social functioning was 0.10, making up 12.59% of the total effect, while gender did not play a moderating role.ConclusionIllness perception and social functioning may independently and accumulatively mediate the association between SES and HRQoL. Nurses should consider developing individual intervention program for young and middle-aged MHD patients with low SES, focusing on establishing targeted counseling and health education strategies corresponding to illness perception and social functioning to help patients improve their HRQoL.
PRIME: a probabilistic neural network approach to solar wind propagation from L1
Authors: O’Brien Connor , Walsh Brian M. , Zou Ying , Tasnim Samira , Zhang Huaming , Sibeck David Gary 
Published: September 2023

Introduction: For the last several decades, continuous monitoring of the solar wind has been carried out by spacecraft at the first Earth-Sun Lagrange point (L1). Due to computational expense or model limitations, those data often must be propagated to some point closer to the Earth in order to be usable by those studying the interaction between Earth’s magnetosphere and the solar wind. The current most widely used tool to propagate measurements from L1 (roughly 235 RE upstream) to Earth is the planar propagation method, which includes a number of known limitations. Motivated by these limitations, this study introduces a new algorithm called the Probabilistic Regressor for Input to the Magnetosphere Estimation (PRIME).Methods: PRIME is based on a novel probabilistic recurrent neural network architecture, and is capable of incorporating solar wind time history from L1 monitors to generate predictions of near-Earth solar wind as well as estimate uncertainties for those predictions.Results: A statistical validation shows PRIME’s predictions better match MMS magnetic field and plasma measurements just upstream of the bow shock than measurements from Wind propagated to MMS with a minimum variance analysis-based planar propagation technique. PRIME’s continuous rank probability score (CRPS) is 0.214σ on average across all parameters, compared to the minimum variance algorithm’s CRPS of 0.350σ. PRIME’s performance improvement over minimum variance is dramatic in plasma parameters, with an improvement in CRPS from 2.155 cm−3 to 0.850 cm−3 in number density and 16.15 km/s to 9.226 km/s in flow velocity VX GSE.Discussion: Case studies of particularly difficult to predict or extreme conditions are presented to illustrate the benefits and limitations of PRIME. PRIME’s uncertainties are shown to provide reasonably reliable predictions of the probability of particular solar wind conditions occurring.Conclusion: PRIME offers a simple solution to common limitations of solar wind propagation algorithms by generating accurate predictions of the solar wind at Earth with physically meaningful uncertainties attached.
Gestión de las contrataciones y su influencia en la ejecución presupuestal
Authors: Pajuelo Pérez Lady Diana 
Published: September 2023

La gestión pública moderna es aquella orientada a resultados al servicio del ciudadano. El estudio tuvo como objetivo determinar la relación entre la gestión de las contrataciones y su influencia en la ejecución presupuestal. Se llevó a cabo bajo el paradigma positivista, enfoque cuantitativo, diseño no experimental de corte transversal, correlacional. La técnica considerada para el estudio fue la encuesta e instrumentos dos cuestionarios para medir las variables, fueron validados por expertos en la gestión pública y la confiabilidad fue altamente confiables. La muestra estuvo conformada por 110 trabajadores de la unidad ejecutora de la Dirección de economía y finanzas de la Policía Nacional del Perú. Los resultados demostraron que la gestión de las contrastaciones se encuentra en un nivel ineficiente 35.5% y moderado la ejecución presupuestal con 50.9%. Se concluyó que la contratación pública sirve como un instrumento para el logro de fines políticos en una eficiente ejecución presupuestal.
ASSESMENT PEMBELAJARAN BAHASA INDONESIA SMPIT AL-AZHAR KOTA JAMBI PADA MASA PANDEMI COVID-19
Authors: Ana Juliana , Setyonegoro Agus , Yusra Hilman 
Published: September 2023

Abstrak-Tujuan penelitian ini adalah untuk mengetahui bagaimana assesment pembelajaran bahasa Indonesia kelas VIII SMP Islam Terpadu Al-Azhar Kota Jambi pada Masa Pandemi Covid-19 Tahun Ajaran 2021/2022. Penelitian ini menggunakan pendekatan kualitatif dengan mengaplikasikan metode studi kasus. Pemerolehan data primer dalam penelitian ini menggunakan teknik wawancara, dan data sekunder dari dokumentasi. Analisis data meggunakan model deskriptif. Dari hasil penelitian yang dilakukan diperoleh bahwa guru bahasa Indonesia kelas VIII SMP Islam Terpadu Al-Azhar Kota Jambi telah melakukan penilaian pada tiga ranah sesuai dengan Kurikulum 13 yaitu, ranah sikap, pengetahuan dan keterampilan yang tetap berpedoman kepada rubik penilaian. Penilaian terfokus kepada KD Berita pada aspek mendengarkan dan berbicara, KD Puisi pada aspek membaca, serta KD Slogan dan Poster pada aspek menulis. Namun, dari tiga ranah penilaian tersebut, masih terdapat komponen penilaian yang tidak terlaksana, seperti pada penilaian pengetahuan dan keterampilan, dikarenakan faktor keterbatasan waktu yang diberikan pada masa pandemi covid-19, dan banyaknya materi serta rubik penilaian yang harus diisi. Dari hasil penelitian disarankan agar guru lebih meningkatkan lagi implementasi assesment dalam pembelajaran, baik itu menyusun dan melaksanakan proses penilaian pada tiga ranah penilaian yaitu penilaian sikap, pengetahuan maupun keterampilan.
Kata kunci: Assesment, Covid-19, Pembelajaran
PENINGKATAN KEMAMPUAN MENERAPKAN MODEL PEMBELAJARAN KOOPERATIF TIPE NHT (NUMBER HEAD TOGETHER) MELALUI SUPERVISI KLINIS DENGAN PENDEKATAN KOLABORATIF
Authors: Siburian Panigoran 
Published: September 2023

Abstrak-Tujuan penelitian ini adalah untuk meningkatkan kemampuan guru kelas dalam menerapkan model pembelajaran kooperatif tipe NHT (Number Head Together) melalui supervisi klinis dengan Pendekatan Kolaboratif di SD Swasta Pauly Mandiri.. Subjek penelitian ini adalah guru kelas di SD Swasta Pauly Mandiri yang berjumlah lima orang. Fokus penelitian adalah penerapan supervisi klinis dengan pendekaan kolaboratif untuk meningkatkan kemampuan menerapkan model pembelajaran kooperatif tipe NHT (Number Head Together) pada guru kelas di SD Swasta Pauly Mandiri. Desain penelitian yang digunakan adalah penelitian tindakan sekolah yang dilaksanakan sebanyak dua siklus. Setiap siklus terdiri dari empat tahap, yakni: perencanaan, pelaksanaan, pengamatan, dan refleksi. Instrumen yang digunakan untuk mengumpulkan data adalah instrumen telaah RPP dan lembar observasi kemampuan guru menerapkan model pembelajaran kooperatif tipe NHT (Number Head Together). Hasil penelitian menemukan pada siklus I skor kemampuan guru menerapkan model pembelajaran kooperatif tipe NHT (Number Head Together ) adalah 77,27 dengan kategori cukup. Selanjutnya, pada siklus II skor kemampuan guru menerapkan model pembelajaran kooperatif tipe NHT adalah 90,91 dengan kategori amat baik. Jadi, hasil penelitian ini menunjukkan bahwa penerapan supervisi klinis dengan pendekatan kolaboratif dapat meningkatkan kemampuan guru kelas dalam menerapkan model pembelajaran kooperatif tipe NHT (Number Head Together ) di SD Swasta Pauly Mandiri.
NILAI BUDAYA LEGENDA BUKIT PERAK SEBAGAI BAHAN AJAR BAHASA INDONESIA KELAS X
Authors: Stalis Siti Stalis Fiana Darazah , Fitrah Yundi , Dewi Yusra 
Published: September 2023

Abstrak-Penelitian ini ditujukan agar dapat menggambarkan nilai budaya yang terkandung dalam Legenda Bukit Perak sebagai Bahan Ajar Bahasa Indonesia untuk Kelas X SMA. Metode yang digunakan dalam penelitian ini adalah metode deskriptif subjektif kualitatif. Data dalam penelitian ini adalah nilai budayadalam Legenda Bukit Perak. Sumber informasi dalam penelitian ini terdiri dari data primer dan data sekunder. Sumber informasi penting dalam penelitian ini yaitu data primer, berupa kata-kata, kalimat, bagian, dialog dan narasi dari Legenda Bukit Perak. Informasi Data sekunder seperti berasal dari buku, buku harian, artikel yang ada hubungannya dengan penelitian. Hasil penelitian menemukan banyak kualitas nilai budaya yang terkandung dalam Legenda Bukit Perak. Kualitas nilai budaya ini disusun berdasarkan lima klasifikasi hubungan manusia dalam budaya, khususnya: (1) nilai budaya hubungan manusia dengan Tuhan, (2) nilai budaya hubungan manusia dengan alam, (3) nilai budaya hubungan manusia dengan masyarakat, (4) nilai budaya hubungan manusia dengan manusia lain, (5) nilai budaya hubungan manusia dengan diri sendiri. Dari lima kategori hubungan manusia dalam budaya, ada satu bagian yang tidak ditemukan, yaitu nilai keikhlasan dalam hubungan manusia dengan manusia lain. Nilai budaya dalam Legenda Bukit Perak dapat diterapkan dalam kehidupan sehari-hari dan dapat dimanfaatkan sebagai bahan ajar bahasa Indonesia kelas X SMA dengan menghubungkannya dengan model bahan ajar.
Kata kunci : bahan ajar, legenda, nilai budaya