bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Geotechnical Modelling Framework for the Tilting Analysis of Offshore Monopiles Under Environmental Cyclic Loading
Authors: Pisanò Federico , Liu Haoyuan , Kementzetzidis Evangelos 
Published: January 2023

Abstract
The development of offshore wind farms requires advanced knowledge and technology, particularly with regard to the design and installation of foundation systems. Offshore wind turbine foundations, such as monopiles, cannot be adequately designed without in-depth analysis of soil-foundation interaction under environmental cyclic loads, such as those induced by wind and marine waves. Serviceability criteria for offshore monopiles include the estimation of long-term, permanent tilt under long-lasting cycling. In the lack of well-established analysis methods, both experimental and computational studies have been carried out in the last decade to support the fundamental understanding of cyclic monopile–soil interaction mechanisms, and in turn the conception of engineering methods for monopile tilt predictions. With regard to the case of monopiles in sandy soil, this paper summarises recent work on the 3D finite element (FE) modelling of monopile tilt based on the SANISAND-MS model proposed by Liu et al. (2019) [1], which enables realistic simulation of cyclic sand ratcheting and densification around the pile. Overall, the presented numerical results confirm the suitability of the SANISAND-MS 3D FE framework as well as, however, its high computational costs. To foster more efficient application to geotechnical design, it is shown how the same theoretical framework on which the SANISAND-MS formulation is based, can be exploited to derive 1D pile-soil interaction models for the p-y-type analysis of cyclically loaded monopiles. In this respect, the importance of preliminary 3D FE modelling and linking to site investigation data (e.g., CPT profiles) is recognised as key to the practical calibration and use of cyclic p-y models.
Cost-effectiveness of rapid assessment of potential ischaemic heart disease with CT coronary angiography
Authors: Thokala Praveen , Goodacre Steve , Oatey Katherine , O'Brien Rachel , Newby David E , Gray Alasdair 
Published: January 2023

ObjectivesTo estimate the cost-effectiveness of early CT coronary angiography (CTCA) for intermediate risk patients with suspected acute coronary syndrome (ACS), compared with standard careMethodsWe performed within-trial economic analysis using data from the RAPID-CTCA randomised trial, and long-term modelling of cost-effectiveness using secondary data sources to estimate the cost-effectiveness of early CTCA compared with standard care for patients with suspected ACS attending acute hospitals in the UK. Cost-effectiveness was estimated as the incremental cost per quality-adjusted life year (QALY) gained, and the probability of each strategy being cost-effective at varying willingness-to-pay per QALY gained.ResultsThe within-trial analysis showed that there were no demonstrable differences in costs or QALYs between early CTCA and standard care, with point estimates suggesting higher costs (£7414 vs £6845: mean difference £569, 95% CI -£208 to £1335; p=0.1521) and lower QALYs (0.749 vs 0.758, mean difference −0.009, 95% CI −0.026 to 0.010; p=0.377) in the CTCA arm. The long-term economic analysis suggested that, on average, CTCA was slightly less effective than standard care alone with 0.025 quality-adjusted life years lost per patient treated and was more expensive with additional costs of £481 per patient treated. At a threshold of £20 000 per QALY, CTCA has 24% probability of being cost-effective.ConclusionsThere are no demonstrable differences in within-trial costs and QALYs, and long-term cost-effectiveness modelling suggested higher long-term costs with CTCA and uncertain effect on long-term QALYs, making routine use of CTCA for suspected ACS unlikely to be a cost-effective use of NHS resources.
AMPK Phosphorylates ZDHHC13 to Increase MC1R Activity and Suppress Melanomagenesis
Authors: Sun Yu , Li Xin , Yin Chengqian , Zhang Judy , Liang Ershang , Wu Xianfang , Ni Ying , Arbesman Joshua , Goding Colin R. , Chen Shuyang 
Published: January 2023

AbstractInherited genetic variations in the melanocortin-1 receptor (MC1R) responsible for human red hair color (RHC) variants are associated with impaired DNA damage repair and increased melanoma risk. MC1R signaling is critically dependent on palmitoylation, primarily mediated by the protein acyltransferase zinc finger DHHC-type palmitoyltransferase 13 (ZDHHC13). A better understanding of how ZDHHC13 is physiologically activated could help identify approaches to prevent melanomagenesis in redheads. Here, we report that AMP-activated protein kinase (AMPK) phosphorylates ZDHHC13 at S208 to strengthen the interaction between ZDHHC13 and MC1R-RHC, leading to enhanced MC1R palmitoylation in redheads. Consequently, phosphorylation of ZDHHC13 by AMPK increased MC1R-RHC downstream signaling. AMPK activation and MC1R palmitoylation repressed UVB-induced transformation of human melanocytes in vitro and delayed melanomagenesis in vivo in C57BL/6J-MC1R-RHC mice. The importance of AMPK to MC1R signaling was validated in human melanomas where AMPK upregulation correlated with expression of factors downstream from MC1R signaling and with prolonged patient survival. These findings suggest AMPK activation as a promising strategy to reduce melanoma risk, especially for individuals with red hair.Significance:Phosphorylation of ZDHHC13 by AMPK at S208 promotes MC1R activation and suppresses melanocyte transformation, indicating activation of AMPK as a potential approach to prevent melanoma in people with red hair.
Long-term monitoring of pelicans in National Chambal Sanctuary, India
Authors: Singh Lala A.K. , Sharma Rishikesh K. 
Published: January 2023

Monitoring of Gharial Gavialis gangeticus in National Chambal Sanctuary (NCS) since 1983 has resulted in collection of data on other ecological associates, located between 25.8474–26.4389 0N, 76.5645–79.2132 0E. One such beneficiary of this long term monitoring program are the pelicans, locally called ‘Hawaseel’. Pelican species visiting Chambal from November to March include the Dalmatian Pelecanus crispus, Great White Pelecanus onocrotalus, and Spot-billed Pelecanus philippensis. Species-wise separation of pelicans at the sites of congregation is often difficult. The total number of pelicans counted during the annual census from 2003 to 2016 was 4,429. The study area extends over 435 km comprising 12 study zones, 99% counts were made in the study zones X, XI and XII. These zones stretch over 115 km that occur near the confluence of Chambal with river Yamuna. Here, the river is deep. Other large birds seen with the pelican squadrons are groups of Cormorant Phalacrocorax carbo, Painted Stork Mycteria leucocephala, Nakta or Comb Duck Sarkidiornis melanotos, and the Greylag Goose Anser anser. Other large birds seen on the riverbanks were the Common Crane Grus grus, Sarus Crane Grus antigon, Greater Flamingo Phoenicopterus species, and Demoiselle Crane Grus virgo. The study provides a baseline about the population of pelicans and the availability of large wetland birds in NCS. The biodiversity significance of NCS got highlighted because of the ongoing gharial conservation programme. The Chambal River Sanctuary is a composite unit of several un-notified ‘core areas’. The sanctuary fulfills six of the nine criteria for possible consideration as an international Ramsar Wetland.
Pietism, the Brethren Movement, and the Globalization of Evangelical Christian Practice
Authors: DeBernardi Jean 
Published: January 2023

Abstract
This paper explores the influence of Pietism on the radical evangelical Christian movement known as the Open Brethren movement. In the 1830s, Anthony Norris Groves (1795–1853) met with German Lutheran missionary Karl Rhenius in India and praised his methods, which included support for indigenous Christian leaders and the independent churches that they led. Karl Gützlaff promoted similar methods in China and influenced wealthy London Brethren to found the China Evangelization Society (CES) in 1850. The CES founders also took the Moravians as a model, noting that a single congregation had launched a global missionary movement that had perpetuated itself from generation to generation. Although they had no formal relationship with the Moravian United Brethren, the Open Brethren knew of their work and that of Pietist institutions like the Francke Foundations both through personal contacts and publications. This paper utilizes the concept of “ensampling” to analyze the ways that Open Brethren founders modeled their work on practices that Pietist missionaries and philanthropists had developed in the long eighteenth century.
Immersed in Dependency: American Missionaries, Empires, and India in the 1830s
Authors: Lenz Darin D. 
Published: January 2023

Abstract
In March of 1831, three American missionary families commenced service with the American Marathi Mission in Bombay. In just over three years, half of the party had died, and the survivors set sail for America. Their story is like what happened to many American missionaries at the end of the long eighteenth century who sought to expand the empire of Christ. From their voyage on the high seas to their everyday life in Bombay, they were confronted by their various states of dependence. Forced to reckon with unfamiliar social, cultural, economic, and political realities, they struggled on the margins of Anglo-Indian society. This article explores the uneasy relationship between American missionaries, who were acutely aware of their dependency on others as colonial interlopers, and the maritime empires they encountered.
Finding Common Ground: Halle Pastors in North America and Their Shifting Stance Towards a Transnational Mission to Native Americans, 1742–1807
Authors: Berger Markus 
Published: January 2023

Abstract
While Heinrich Melchior Mühlenberg and his pastor colleagues from Halle have gone down in history for their pioneering work – organizing the Lutheran Church on North American soil – they are not known for missionary projects to Native Americans. This article examines how things changed after a second generation of Halle pastors arrived in Pennsylvania in the 1760s. It was, above all, down to Mühlenberg’s later son-in-law Johann Christoph Kunze, who had a rather different view on America’s indigenous people. During his whole lifespan in America, Kunze pursued his goal of establishing a mission to Native Americans. This engagement contributed to a paradigm shift in the Lutheran Church. In contrast to Mühlenberg and the first generation of Halle pastors, Kunze sought transnational support that was no longer exclusively centered in Halle’s Glaucha Institutions but based on pan-Protestant, maritime networks.
Echolalia as defined by parent communication partners
Authors: Cohn Eli G , McVilly Keith R , Harrison Matthew J 
Published: January 2023

Backgrounds and aims Echolalia, the repetition of previous speech, is highly prevalent in Autism. Research into echolalia has historically assumed a clinical standpoint, with two opposing paradigms, behaviourism and developmentalism, offering differing support and intervention programs. These paradigms offer a multitude of clinical operationalised definitions; despite attempts, there continue to be challenges regarding how echolalia is to be defined. Stepping out of the dichotomous clinically orientated literature, we examined how parents summarise and formalise their understanding of echolalia as a communication partner. The objectives of this study were three-fold: (1) to investigate how echolalia is described and defined by parents; (2) to examine if existing clinical definitions align with those of parents; and (3) to begin to consider the implications of such findings for a collaborative approach between clinical perspectives and the parent experience. We bring to the fore the voices of parents, who have historically remained absent from echolalia literature. That is to say, we step outside of the clinical realm and listen to parents: something which has been previously unconsidered but represents a new vital addition to the echolalia literature. Methods We employed a Grounded Theory approach to document the definitions of 133 parents. Results We found that parents reported a multiplicity of important elements that are key to their understanding of echolalia. Conclusions and implications Additionally, we found that clinical definitions do not resonate within the parent experience; parents experience echolalia in a different way to that of clinicians and parents can offer insight into our understanding of the phenomena. Our findings show that while some parents might align themselves with either a behavioural or developmental positionality, sometimes there is an overlap depending upon the context in which their child repeats and some parents advance interpretations that are not readily aligned with either of the traditional clinical schools of thought. We present implications for both clinicians and parents in ways that point towards a collaborative approach to support the person with echolalia.
Urine-based multi-omic comparative analysis of COVID-19 and bacterial sepsis-induced ARDS
Authors: Batra Richa , Uni Rie , Akchurin Oleh M. , Alvarez-Mulett Sergio , Gómez-Escobar Luis G. , Patino Edwin , Hoffman Katherine L. , Simmons Will , Whalen William , Chetnik Kelsey , Buyukozkan Mustafa , Benedetti Elisa , Suhre Karsten , Schenck Edward , Cho Soo Jung , Choi Augustine M. K. , Schmidt Frank , Choi Mary E. , Krumsiek Jan 
Published: January 2023

AbstractBackgroundAcute respiratory distress syndrome (ARDS), a life-threatening condition during critical illness, is a common complication of COVID-19. It can originate from various disease etiologies, including severe infections, major injury, or inhalation of irritants. ARDS poses substantial clinical challenges due to a lack of etiology-specific therapies, multisystem involvement, and heterogeneous, poor patient outcomes. A molecular comparison of ARDS groups holds the potential to reveal common and distinct mechanisms underlying ARDS pathogenesis.MethodsWe performed a comparative analysis of urine-based metabolomics and proteomics profiles from COVID-19 ARDS patients (n = 42) and bacterial sepsis-induced ARDS patients (n = 17). To this end, we used two different approaches, first we compared the molecular omics profiles between ARDS groups, and second, we correlated clinical manifestations within each group with the omics profiles.ResultsThe comparison of the two ARDS etiologies identified 150 metabolites and 70 proteins that were differentially abundant between the two groups. Based on these findings, we interrogated the interplay of cell adhesion/extracellular matrix molecules, inflammation, and mitochondrial dysfunction in ARDS pathogenesis through a multi-omic network approach. Moreover, we identified a proteomic signature associated with mortality in COVID-19 ARDS patients, which contained several proteins that had previously been implicated in clinical manifestations frequently linked with ARDS pathogenesis.ConclusionIn summary, our results provide evidence for significant molecular differences in ARDS patients from different etiologies and a potential synergy of extracellular matrix molecules, inflammation, and mitochondrial dysfunction in ARDS pathogenesis. The proteomic mortality signature should be further investigated in future studies to develop prediction models for COVID-19 patient outcomes.
The gender dimensions of travel time use in Germany
Authors: Chidambaram Bhuvanachithra , Scheiner Joachim 
Published: January 2023

AbstractTime use during travel has been the subject of considerable research in recent years thanks to its crucial role in determining the utility of travel time. While most of these studies have documented the effects of demographics and trip characteristics on travel time use, the effect of gender is still ambiguous. To understand the role of gender in travel time use, we explore the effect of gender interaction with non-travel time use behavior (daily habits, multitasking and preferences), joint travel (travel companion), and economic situation (income and working hours) on various time use activities (reading, ICT use and talking) during travel. Moreover, we address the mixed and scant evidence from prior studies regarding the effect of sociodemographic, residential and trip characteristics on travel time use. The study used the cross-sectional German Time Use Survey 2012/13 data and employed multi-level binary logistic regression for analysis. The results indicate four important findings: (1) women's socializing during travel is principally influenced by primary time spent on interaction with children and ICT usage, while men’s socializing during travel is positively influenced by traveling with their partners and socializing habits; (2) both women’s and men’s solitary activities during travel (e.g. reading/ICT use) are influenced by their economic situation (e.g. income, working hours) and daily non-travel time use habits (reading habits/ICT use habits); (3) individuals’ solitary time use during travel is positively influenced by other potential determinants such as living in semi-urban areas/East Germany, driving or traveling by public transport; and (4) socializing during travel is positively influenced by living with partners, having young children, evening/night/weekend trips, maintenance/leisure trips, traveling by public transport and walking.
Evaluating an advanced double intravenous vasopressor automated system to treat hypotension during spinal anesthesia for cesarean delivery: a randomized controlled trial
Authors: Tan Hon Sen , Nagarajan Singaraselvan , Chan Jason Ju In , Tan Chin Wen , Sultana Rehena , Sia Alex Tiong Heng , Sng Ban Leong 
Published: January 2023

Abstract
Background
The optimal treatment of hypotension during spinal anaesthesia is uncertain. A novel double intravenous vasopressor automated (DIVA) system reduces hypotension compared to standard care, and was subsequently modified to an advanced-DIVA (ADIVA) system. The primary objective was to compare ADIVA versus DIVA on incidence of hypotension (systolic BP (SBP) < 80% baseline).

Methods
We conducted a randomized-controlled trial in women undergoing elective cesarean delivery under spinal anesthesia. SBP and heart rate were measured continuously using a Nexfin monitor. ADIVA delivered 25 μg phenylephrine (heart rate > 60 beats.min−1) or 2 mg ephedrine (heart rate < 60 beats.min−1) at SBP 90 to 110% of baseline, 50 μg phenylephrine or 4 mg ephedrine at SBP 80 to 90%, and 75 μg phenylephrine or 6 mg ephedrine at SBP < 80%. ADIVA calculated the trend of SBP; vasopressors were administered rapidly if SBP trended downward, or 30 s if SBP trended upward. In contrast, DIVA delivered 25 μg phenylephrine or 2 mg ephedrine at SBP 90 to 100% of baseline, and 50 μg phenylephrine or 4 mg ephedrine at SBP < 90%. Boluses were followed by a 10-s lockout. Other outcomes included hypertension (SBP > 120% baseline), vasopressor consumption, clinical outcomes, and performance measures from spinal anesthesia to fetal delivery.

Results
We analyzed 94 parturients (ADIVA: n = 46, DIVA: n = 48), with no difference in the incidence of hypotension between ADIVA (78.3%) and DIVA (83.3%, p = 0.677). ADIVA had significantly higher proportion of hypotensive SBP readings, lower phenylephrine consumption and higher umbilical arterial pH. There was no difference in hypertension, bradycardia, ephedrine consumption, intravenous fluid volume, nausea/vomiting, Apgar scores, and umbilical venous pH or lactate. ADIVA maintained SBP higher above baseline with greater fluctuation than DIVA.

Conclusion
ADIVA was associated with a greater proportion of hypotensive SBP readings, reduced phenylephrine consumption, and increased umbilical arterial pH than DIVA. Further research is needed to determine the optimal method of vasopressor delivery in parturients undergoing cesarean delivery.

Trial registration
This study was registered on Clinicaltrials.gov registry (NCT03620942) on 08/08/2018.
Neurological sequelae after encephalitis associated with herpes simplex virus in children: systematic review and meta-analysis
Authors: Rocha Natalie Duran , de Moura Sara Kvitko , da Silva Gabriel Aude Bueno , Mattiello Rita , Sato Douglas Kazutoshi 
Published: January 2023

Abstract
Background
Encephalitis is an inflammation of the cerebral parenchyma manifested by acute symptoms such as fever, headaches, and other neurological disorders. Its etiology is mostly viral, with herpes simplex virus being a frequent etiological agent in children. The development of neurological sequelae is a serious outcome associated with this infection.

Objective
To assess the general prevalence and types of neurological sequelae in children after a case of acute viral encephalitis caused by HSV.

Methods
This systematic review and meta-analysis was developed following the PRISMA guidelines. The literature search was carried out in the MEDLINE, Embase, SciELO, LILACS, Cochrane, CINAHL, PsycINFO, and Web of Science databases. Studies were included of children with confirmed HSV infection and that presented a description of neurological sequelae associated with that infection. For the meta-analysis of general prevalence and of the types of neurological sequelae a random effects model was used.

Results
Of the 2827 articles chosen in the initial search, nine studies were included in the systematic review and meta-analysis. The general prevalence of neurological sequelae was 50.7% (95% CI 39.2–62.2). The most frequent sequelae were related to mental disability, with a 42.1% prevalence (95% CI 30–55.2); on the other hand, the least frequent sequelae were those related with visual impairment, with a 5.9% prevalence (95% CI 2.2–14.6). The included studies presented regular quality and substantial heterogeneity.

Conclusion
Even with antiviral therapy, half of patients will develop some type of disability.
Growing a peritoneal dialysis program in Palestine from zero to 178 patients in 5 years: a single-center experience
Authors: Taher Ameed , Enaya Ahmad , Sarsour Ala , Bahar Sami , Hamayel Dalia , Safarini Omar , Hamdan Zakaria , Nazzal Zaher 
Published: January 2023

Abstract
Introduction
Kidney failure is rapidly rising in Palestine, as the number of patients receiving maintenance dialysis has quadrupled in the last 15 years. In this study, we share an overview of our experience growing a peritoneal dialysis (PD) program from zero to 178 patients in 5 years at An-Najah National University Hospital in Palestine, presenting some challenges and ways to overcome them.

Methods
This was a single-center retrospective study of patients treated with PD from November 2016 to December 2021. Demographic and clinical data were obtained for each patient. In addition, PD discontinuation, peritonitis, and mortality rates were calculated and presented as the primary patient outcomes.

Results
A total of 158 patients were eligible for the study. The mean age was 51.8 ± 16.4 years, and 53.8% of patients were male. Diabetic nephropathy was the most common cause of kidney failure. 63 episodes of peritonitis were diagnosed in 48 patients (30.4%) for a rate of 1 episode/ 38.2 patient-months (0.31 episodes/ patient-years). 20 patients had their PD treatment discontinued, mainly due to psychosocial reasons and infectious and mechanical complications. Death was the fate of 27 patients, with cardiovascular disease and COVID-19 being the two main causes.

Conclusion
The outcomes of this experience proved favorable and showed that PD could serve as a viable option for kidney failure patients in Palestine. Moreover, this study can serve as an example for other places where circumstances are challenging to take the initiative of starting their PD programs.