bluuebunny/crossref_metadata_2025_split huggingface dataset:
Classifying asthma control using salivary and fecal bacterial microbiome in children with moderate‐to‐severe asthma
Authors: Blankestijn Jelle M. , Lopez‐Rincon Alejandro , Neerincx Anne H. , Vijverberg Susanne J. H. , Hashimoto Simone , Gorenjak Mario , Sardón Prado Olaia , Corcuera‐Elosegui Paula , Korta‐Murua Javier , Pino‐Yanes Maria , Potočnik Uroš , Bang Corinna , Franke Andre , Wolff Christine , Brandstetter Susanne , Toncheva Antoaneta A. , Kheiroddin Parastoo , Harner Susanne , Kabesch Michael , Kraneveld Aletta D. , Abdel‐Aziz Mahmoud I. , Maitland‐van der Zee Anke H. ,   the SysPharmPediA Consortium
Published: February 2023

AbstractBackgroundUncontrolled asthma can lead to severe exacerbations and reduced quality of life. Research has shown that the microbiome may be linked with asthma characteristics; however, its association with asthma control has not been explored. We aimed to investigate whether the gastrointestinal microbiome can be used to discriminate between uncontrolled and controlled asthma in children.Methods143 and 103 feces samples were obtained from 143 children with moderate‐to‐severe asthma aged 6 to 17 years from the SysPharmPediA study. Patients were classified as controlled or uncontrolled asthmatics, and their microbiome at species level was compared using global (alpha/beta) diversity, conventional differential abundance analysis (DAA, analysis of compositions of microbiomes with bias correction), and machine learning [Recursive Ensemble Feature Selection (REFS)].ResultsGlobal diversity and DAA did not find significant differences between controlled and uncontrolled pediatric asthmatics. REFS detected a set of taxa, including Haemophilus and Veillonella, differentiating uncontrolled and controlled asthma with an average classification accuracy of 81% (saliva) and 86% (feces). These taxa showed enrichment in taxa previously associated with inflammatory diseases for both sampling compartments, and with COPD for the saliva samples.ConclusionControlled and uncontrolled children with asthma can be differentiated based on their gastrointestinal microbiome using machine learning, specifically REFS. Our results show an association between asthma control and the gastrointestinal microbiome. This suggests that the gastrointestinal microbiome may be a potential biomarker for treatment responsiveness and thereby help to improve asthma control in children.
Mother and clinician experiences of a trial of a video feedback parent–infant intervention for mothers experiencing difficulties consistent with ‘personality disorder’: A qualitative interview study
Authors: Barnicot Kirsten , Parker Jennie , Kalwarowsky Sarah , Stevens Eloise , Iles Jane , Ramchandani Paul , Crawford Mike 
Published: February 2023

AbstractObjectivesWe explored mothers' and clinicians' experiences of a video feedback intervention adapted for perinatal ‘personality disorder’ (VIPP‐PMH) and the acceptability of a randomised controlled trial (RCT) examining its effectiveness.DesignIn‐depth qualitative interviews with participants from a two‐phase feasibility study of the VIPP‐PMH intervention. Participants were mothers experiencing enduring difficulties in managing emotions and relationships, consistent with a ‘personality disorder’, and their 6‐ to 36‐month‐old children.MethodsForty‐four qualitative interviews were conducted, including all nine mothers receiving VIPP‐PMH during the pilot phase, 25 of the 34 mothers participating in the RCT (14 allocated to the VIPP‐PMH arm and 9 from the control arm), 11 of the 12 clinicians delivering VIPP‐PMH and one researcher. Interview data were thematically analysed.ResultsMothers described feeling motivated to take part in the research and understood the need for randomisation. Research visits were largely experienced positively, with some suggestions for improvement in questionnaire timing and accessibility. Almost all mothers initially felt anxious about being filmed, but reported positive experiences of the intervention, particularly valuing its non‐judgemental, positive and child‐focussed nature, their supportive relationship with the therapist and the insights they gained on their child.ConclusionsThe findings indicate the likely feasibility and acceptability of undertaking a future definitive RCT of the VIPP‐PMH intervention in this population. In designing a future trial, a positive and non‐judgemental therapeutic relationship will be important to allay mothers' anxieties about being filmed, and careful consideration should be given to the timing and accessibility of questionnaires used.
Killer to cure: Expression and production costs calculation of tobacco plant‐made cancer‐immune checkpoint inhibitors
Authors: Ridgley Laura A. , Falci Finardi Nicole , Gengenbach Benjamin B. , Opdensteinen Patrick , Croxford Zack , Ma Julian K.‐C. , Bodman‐Smith Mark , Buyel Johannes F. , Teh Audrey Y.‐H. 
Published: February 2023

SummaryImmune checkpoint inhibitors (ICIs) have achieved huge clinical success. However, many still have limited response rates, and are prohibitively costly. There is a need for effective and affordable ICIs, as well as local manufacturing capacity to improve accessibility, especially to low‐to‐middle income countries (LMICs). Here, we have successfully expressed three key ICIs (anti‐PD‐1 Nivolumab, anti‐NKG2A Monalizumab, and anti‐LAG‐3 Relatimab) transiently in Nicotiana benthamiana and Nicotiana tabacum plants. The ICIs were expressed with a combination of different Fc regions and glycosylation profiles. They were characterized in terms of protein accumulation levels, target cell binding, binding to human neonatal Fc receptors (hFcRn), human complement component C1q (hC1q) and various Fcγ receptors, as well as protein recovery during purification at 100 mg‐ and kg‐scale. It was found that all ICIs bound to the expected target cells. Furthermore, the recovery during purification, as well as Fcγ receptor binding, can be altered depending on the Fc region used and the glycosylation profiles. This opens the possibility of using these two parameters to fine‐tune the ICIs for desired effector functions. A scenario‐based production cost model was also generated based on two production scenarios in hypothetical high‐ and low‐income countries. We have shown that the product accumulation and recovery of plant production platforms were as competitive as mammalian cell‐based platforms. This highlights the potential of plants to deliver ICIs that are more affordable and accessible to a widespread market, including LMICs.
Cross‐temporal grounding
Authors: Correia Fabrice , Merlo Giovanni 
Published: February 2023

AbstractCross‐temporal grounding is a type of grounding whereby present facts about the past (for example that Caesar was alive) are explained in terms of past facts (for example that Caesar is alive) rather than in terms of other present facts. This paper lays the foundations for a theory of cross‐temporal grounding. After introducing the general idea of a type of grounding connecting facts to past facts, we offer two arguments that past‐directed facts require cross‐temporal grounds—the ‘argument from intimacy’ and the ‘argument from past explanation’. We then go on to show that cross‐temporal grounding statements can be understood as instances of a type of explanation which is perfectly legitimate and intelligible, even if somewhat unusual. Finally, we explain how the logic of grounding can be extended to accommodate cross‐temporal grounding statements.
Social Media and Advertising Literacy of the Older Adults
Authors: Čábyová Ľudmila , Hrušková Alena , Rybnikárová Martina 
Published: February 2023

In their study on advertising literacy, the authors focus their attention on the target group of the older adults This is a very attractive target group that is always eager to shop and try new products. They also have sufficient financial resources to meet their interests and needs. This target group is also very attractive to advertisers, but their ability to understand advertising may be impaired compared to younger target groups. This is due to the use of new digital forms of advertising, which may not be as comprehensible to older adults. In their study, the authors surveyed the level of advertising literacy in a sample of older adults. The aim was to determine whether older adults understood the intent and objectives of advertising and whether they were able to identify the advertiser (advertiser). The authors also investigated the advertising literacy of older adults in relation to other marketing communication tools, such as public relations, product placement, and social media advertising.
Reviewer Acknowledgements for Studies in Media and Communication, Vol. 11, No. 1
Authors: Johnson Patricia 
Published: February 2023

Studies in Media and Communication (SMC) would like to acknowledge the following reviewers for their assistance with peer review of manuscripts for this issue. Many authors, regardless of whether SMC publishes their work, appreciate the helpful feedback provided by the reviewers. Their comments and suggestions were of great help to the authors in improving the quality of their papers. Each of the reviewers listed below returned at least one review for this issue.Reviewers for Volume 11, Number 1Aina Fernàndez Aragonès, Tecnocampus-UPF, SpainAmie Jones, University of Georgia, USAAnita Šulentić, Edward Bernays University College, CroatiaAyşe Aslı Sezgin, Çukurova University, TurkeyCamelia Cmeciu, Danubius University of Galati, RomaniaGiorgio Poletti, University of Ferrara, ItalyHerman, Universitas HKBP Nommensen Pematangsiantar, IndonesiaImed Ben Labidi, Doha Institute for Graduate Studies, USAKrešimir Dabo, Edward Bernays University College, CroatiaKrešimir Žažar, University of Zagreb, CroatiaMatthias Degen, Westphalian University of Applied Sciences, GermanyMiguel Álvarez-Peralta, University Rey Juan Carlos, SpainMunira Fayzulloeva, Tajik State University of Law, TajikistanNavid Darvishzadeh, Georgia State University, USANingyang Chen, Soochow University, ChinaPadilla-Castillo Graciela, Complutense University of Madrid, SpainRafael Angel Salazar Martínez, University of Holguin-Mayari Municipality Center, CubaRebeca Suarez-Alvarez, Rey Juan Carlos University, SpainSixto-García José, University of Santiago de Compostela, SpainVerlumun Celestine Gever, University of Nigeria, NigeriaXiao Li, Hubei Institute of Fine Arts, ChinaXin Wang, North China Institute of Science and Technology, ChinaYoung Joon Lim, University of Texas Rio Grande Valley, USAYufan Sunny Qin, James Madison University, USA Patricia JohnsonEditorial AssistantOn behalf of,The Editorial Board of Studies in Media and CommunicationRedfame Publishing9450 SW Gemini Dr. #99416Beaverton, OR 97008, USAURL: http://smc.redfame.com
Hyperprofessionalized and Commodified: A Case Study Examination of FBS Bowl Games and the Utilization of Football Players as Programmatic Promotional Material
Authors: Corr Chris , Southall Richard M. , Southall Crystal , Hart Richard J. 
Published: February 2023

Football Bowl Subdivision (FBS) football games are presented in a hypercommercialized manner by television broadcast networks through the targeted use of in-game graphics and corporatized content. While commercialized FBS football broadcast components have been analyzed within the frameworks of a hypercommercialized National Collegiate Athletic Association and media institutional logics, an analysis of commentator language has yet to be examined within the larger institutional field of FBS football broadcasts. Utilizing agenda setting and media framing as frameworks, this case study examined the manner in which commentators frame FBS football players as professionals in a hypercommercialized institutional setting. From a sample of 18 FBS bowl games during the 2019–20 season, discourse and thematic analysis reveal that commentators frame FBS football players in the context of their future professional opportunities (i.e., National Football League). The framing of FBS football players as professionals aligns with extant literature examining the broader institutional field of broadcast media and logics pervasive in the National Collegiate Athletic Association as an organization. The commodification of FBS football players as integral components to strategic programmatic content promoting future broadcast programming is discussed.
2008 economic crisis impact on perinatal and infant mortality in Southern European countries
Authors: Doetsch Julia Nadine , Almendra Ricardo , Severo Milton , Leão Teresa , Pilot Eva , Krafft Thomas , Barros Henrique 
Published: February 2023

IntroductionThe study of crisis events provides important lessons to prepare for upcoming events. The Great Recession’s impact on perinatal health in Europe can provide relevant insights into the healthcare and social protection systems’ response to the protection of the health of the most vulnerable groups.ObjectiveTo assess time trends and international disparities in perinatal mortality rates (PMR) and infant mortality rates (IMR), following the Great Recession, and their association with socioeconomic indicators in Portugal, Greece, Italy and Spain.MethodsAssociations were assessed through generalised linear models for all four countries. A Poisson joinpoint regression model was applied to explore PMR and IMR trend changes between 2000 and 2018. Country disparities were analysed using mixed-effects multilevel models.ResultsIMR and PMR have decreased overall in the four selected countries between 2000 and 2018. Still, whereas in Spain, Italy and Portugal the decreasing pace was attenuated after 2009, in Greece a positive trend was found after the 2008 crisis. IMR and PMR were significantly associated with socioeconomic indicators in all four countries. National disparities in the evolution of IMR and PMR were significantly associated with most socioeconomic indicators between 2000 and 2018.ConclusionOur results confirm the impact of the Great Recession on PMR and IMR trends in all four countries, taking recurring associations between macroeconomic cycles, variations in mortality trends, macroeconomic volatility and stagnation of IMR and PMR into account. The association with socioeconomic indicators stresses the need to strengthen social protection and healthcare systems to better protect the population’s health from the earliest days.
Contribution of parental health to the subsequent social assistance entry of the family with children: a nationwide register-linked birth cohort study in Finland
Authors: Hiilamo Aapo , Keski-Säntti Markus , Räsänen Sami , Niemelä Mika , Lallukka Tea , Ristikari Tiina 
Published: February 2023

AimOur aim in this paper was to estimate the contribution of different parental specialised health care diagnoses to the subsequent risk of entry into the social assistance system for families with children in the period 1998–2013.MethodsWe used longitudinal population-level register data consisting of all children born in 1997 in Finland and their registered parents (54 960 one and two-parent families with 801 336 observations in the period 1998–2013). Diagnoses assigned in public specialised healthcare and social assistance records were derived from nationwide administrative registers. Measures of parental socioeconomic status and previous diagnoses and the birth weight of the child were adjusted for in regression models which estimated the association between parental diagnoses and entry into the social assistance system in the following year.ResultsFamilies with a parent somatic diagnosis had a risk ratio of 1.4 for social assistance entry in the subsequent year of the diagnosis though substantial variation by diagnosis category was detected. Parent psychiatric diagnoses were linked to a higher, 3.01-fold risk of social assistance entry. Covariate adjustment reduced these risk ratios to 1.2 and 2.1, respectively. Some 2.9% of all social assistance entries may be attributed to parental psychiatric diagnoses while somatic health records account for another 7.2%, making their total contribution over 1/10th of all cases.ConclusionParental specialised healthcare records were associated with a higher risk of social assistance need. Thus more interventions to support financial management are required for parents with psychiatric diagnoses.
Frontotemporal dementia presentation in patients with heterozygous p.H157Y variant ofTREM2
Authors: Ogonowski Natalia , Santamaria-Garcia Hernando , Baez Sandra , Lopez Andrea , Laserna Andrés , Garcia-Cifuentes Elkin , Ayala-Ramirez Paola , Zarante Ignacio , Suarez-Obando Fernando , Reyes Pablo , Kauffman Marcelo , Cochran Nick , Schulte Michael , Sirkis Daniel W , Spina Salvatore , Yokoyama Jennifer S , Miller Bruce L , Kosik Kenneth S , Matallana Diana , Ibáñez Agustín 
Published: February 2023

BackgroundThe triggering receptor expressed on myeloid cell 2 (TREM2) is a major regulator of neuroinflammatory processes in neurodegeneration. To date, the p.H157Y variant ofTREM2has been reported only in patients with Alzheimer’s disease. Here, we report three patients with frontotemporal dementia (FTD) from three unrelated families with heterozygous p.H157Y variant ofTREM2: two patients from Colombian families (study 1) and a third Mexican origin case from the USA (study 2).MethodsTo determine if the p.H157Y variant might be associated with a specific FTD presentation, we compared in each study the cases with age-matched, sex-matched and education-matched groups—a healthy control group (HC) and a group with FTD with neitherTREM2mutations nor family antecedents (Ng-FTD and Ng-FTD-MND).ResultsThe two Colombian cases presented with early behavioural changes, greater impairments in general cognition and executive function compared with both HC and Ng-FTD groups. These patients also exhibited brain atrophy in areas characteristic of FTD. Furthermore, TREM2 cases showed increased atrophy compared with Ng-FTD in frontal, temporal, parietal, precuneus, basal ganglia, parahippocampal/hippocampal and cerebellar regions. The Mexican case presented with FTD and motor neuron disease (MND), showing grey matter reduction in basal ganglia and thalamus, and extensive TDP-43 type B pathology.ConclusionIn all TREM2 cases, multiple atrophy peaks overlapped with the maximum peaks ofTREM2gene expression in crucial brain regions including frontal, temporal, thalamic and basal ganglia areas. These results provide the first report of an FTD presentation potentially associated with the p.H157Y variant with exacerbated neurocognitive impairments.
Timing of physical activity across adulthood on later-life cognition: 30 years follow-up in the 1946 British birth cohort
Authors: James Sarah-Naomi , Chiou Yu-Jie , Fatih Nasri , Needham Louisa P , Schott Jonathan M , Richards Marcus 
Published: February 2023

BackgroundTo assess how timing, frequency and maintenance of being physically active, spanning over 30 years in adulthood, is associated with later-life cognitive function.MethodsParticipants (n=1417, 53% female) were from the prospective longitudinal cohort study, 1946 British birth cohort. Participation in leisure time physical activity was reported five times between ages 36 and 69, categorised into: not active (no participation in physical activity/month); moderately active (participated 1–4 times/month); most active (participated 5 or more times/month). Cognition at age 69 was assessed by tests of cognitive state (Addenbrooke’s Cognitive Examination-III), verbal memory (word learning test) and processing speed (visual search speed).ResultsBeing physically active, at all assessments in adulthood, was associated with higher cognition at age 69. For cognitive state and verbal memory, the effect sizes were similar across all adult ages, and between those who were moderately and most physically active. The strongest association was between sustained cumulative physical activity and later-life cognitive state, in a dose-response manner. Adjusting for childhood cognition, childhood socioeconomic position and education largely attenuated these associations but results mainly remained significant at the 5% level.ConclusionsBeing physically active at any time in adulthood, and to any extent, is linked with higher later-life cognitive state, but lifelong maintenance of physical activity was most optimal. These relationships were partly explained by childhood cognition and education, but independent of cardiovascular and mental health and APOE-E4, suggestive of the importance of education on the lifelong impacts of physical activity.
Occupational risk of SARS-CoV-2 infection: a nationwide register-based study of the Danish workforce during the COVID-19 pandemic, 2020–2021
Authors: Bonde Jens Peter Ellekilde , Begtrup Luise Moelenberg , Jensen Johan Høy , Flachs Esben Meulengracht , Schlünssen Vivi , Kolstad Henrik A , Jakobsson Kristina , Nielsen Christel , Nilsson Kerstin , Rylander Lars , Vilhelmsson Andreas , Petersen Kajsa Kirstine Ugelvig , Soegaard Toettenborg Sandra 
Published: February 2023

ObjectiveMost earlier studies on occupational risk of COVID-19 covering the entire workforce are based on relatively rare outcomes such as hospital admission and mortality. This study examines the incidence of SARS-CoV-2 infection by occupational group based on real-time PCR (RT-PCR) tests.MethodsThe cohort includes 2.4 million Danish employees, 20–69 years of age. All data were retrieved from public registries. The incidence rate ratios (IRRs) of first-occurring positive RT-PCR test from week 8 of 2020 to week 50 of 2021 were computed by Poisson regression for each four-digit Danish Version of the International Standard Classification of Occupations job code with more than 100 male and 100 female employees (n=205). Occupational groups with low risk of workplace infection according to a job exposure matrix constituted the reference group. Risk estimates were adjusted by demographic, social and health characteristics including household size, completed COVID-19 vaccination, pandemic wave and occupation-specific frequency of testing.ResultsIRRs of SARS-CoV-2 infection were elevated in seven healthcare occupations and 42 occupations in other sectors, mainly social work activities, residential care, education, defence and security, accommodation and transportation. No IRRs exceeded 2.0. The relative risk in healthcare, residential care and defence/security declined across pandemic waves. Decreased IRRs were observed in 12 occupations.DiscussionWe observed a modestly increased risk of SARS-CoV-2 infection among employees in numerous occupations, indicating a large potential for preventive actions. Cautious interpretation of observed risk in specific occupations is needed because of methodological issues inherent in analyses of RT-PCR test results and because of multiple statistical tests.