bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predicting molecular mechanisms of hereditary diseases by using their tissue‐selective manifestation
Authors: Simonovsky Eyal , Sharon Moran , Ziv Maya , Mauer Omry , Hekselman Idan , Jubran Juman , Vinogradov Ekaterina , Argov Chanan M , Basha Omer , Kerber Lior , Yogev Yuval , Segrè Ayellet V , Im Hae Kyung ,   GTEx Consortium, Birk Ohad , Rokach Lior , Yeger‐Lotem Esti 
Published: May 2023

AbstractHow do aberrations in widely expressed genes lead to tissue‐selective hereditary diseases? Previous attempts to answer this question were limited to testing a few candidate mechanisms. To answer this question at a larger scale, we developed “Tissue Risk Assessment of Causality by Expression” (TRACE), a machine learning approach to predict genes that underlie tissue‐selective diseases and selectivity‐related features. TRACE utilized 4,744 biologically interpretable tissue‐specific gene features that were inferred from heterogeneous omics datasets. Application of TRACE to 1,031 disease genes uncovered known and novel selectivity‐related features, the most common of which was previously overlooked. Next, we created a catalog of tissue‐associated risks for 18,927 protein‐coding genes (https://netbio.bgu.ac.il/trace/). As proof‐of‐concept, we prioritized candidate disease genes identified in 48 rare‐disease patients. TRACE ranked the verified disease gene among the patient's candidate genes significantly better than gene prioritization methods that rank by gene constraint or tissue expression. Thus, tissue selectivity combined with machine learning enhances genetic and clinical understanding of hereditary diseases.
The influence of different pretreatment methods on the quality of wines made from table grapes
Authors: Zhang W.J. , Zheng X.X. , Tian X.J. , Li Y.Y. , Wang J. 
Published: May 2023

AbstractMeasurement of phenolics, colour parameters, and volatile compounds in wines were made from two varieties of table grapes (‘Zaoheibao’ and ‘Summer Black’) using five pretreatment methods (cold maceration, freezing grapes, lower maturity, fermenting grape juice without skin, and adding tartaric acid) and a control treatment. The effect of the pretreatment methods on the quality of wines was assessed using oenological parameters analysis and volatile compounds analysis. The results indicated that the freezing grape and cold maceration pretreatments improved the colour and increased the contents of phenolic and volatile compounds compared with the control, and freezing was considered to be the most suitable pretreatment method for ‘Zaoheibao’ wine. With respect to ‘Summer Black’ wines, cold maceration and lower maturity were considered to be suitable. Cold maceration enhanced the contents of phenolic and volatile compounds, while lower maturity increased the contents of volatile compounds and total acid. Our results provide new insights into the use of table grapes to make different styles of wine.
The strain-stress state investigation of structural units of the ballast prism by type SP3-5/UA
Authors: S. A. Kostrytsia  , B. M. Tovt  
Published: May 2023

In the article the results of analytical and experimental studies of the stressed-and-strained state of load-bearing elements of structure of ballast prism planner of SPZ-5/UA are presented. The analytical research is performed using the finite element method (FEM). Its results are used during realization of performance dynamic tests on durability. On the basis of analysis of the calculation and experimental data obtained the estimation of durability of construction of ballast prism planner SPZ-5/UA under the action of loads corresponding to the different operating modes is executed.
The mathematic stimulation of transient process in a.c. – system “electric-traction network – locomotive” 3. Switching on main power converter in “free play” mode; the analysis of volts and currents in the power supply input system
Authors: T. M. Mischenko  
Published: May 2023

The article is a continuation of analysis of the electric equivalent AC circuit «traction substation − device of transversal compensation − electric-traction network − electric locomotive DS 3» and the influence on a power transformer in the idle mode, depending on the feeder voltage and the distance of an electric locomotive from a traction substation. The numeral calculations are performed and the voltage and current values in the electric power supply system are analyzed.
Providing details from titanium alloys of anticorrosion protection and decorative paint during chemico-thermal processing into verified nitrogen and oxygen atmosphere
Authors: I. M. Pohreliuk  , O. V. Tkachuk  , Z. O. Siryk  
Published: May 2023

The regularities of the forming of oxynitride layers on the surface of titanium alloys at the controlled modification of preliminarily formed nitride coatings by oxygen are determined. The dependence of the surface colouring of titanium alloys depending on the composition of formed oxynitrides is showed. It is determined that oxynitriding provides the high corrosion resistance of the titanium alloys. The expediency of the differential approach to the choice of the phase-structural state of the surface layers of oxynitrated titanium depending on the aggressive environment is showed.
Standart physico–mechanical characteristics of constructional concrete and their nanotechnological valuation aspects in frame of the theory sliding into a micro-polarized sphere (MPS) with an acceptible probability Vbkni = (1-1,64X0, 135X0,01B)
Authors: V. N. Rudakov  , H. A. Molodchenko  , D. V. Abrakitov  
Published: May 2023

Within the framework of theory of sliding of the micro-polarized environment, developed by V.N. Rudakov,norms of СНиП 2.03.01-84*, norms of Russia СП 101-2003 and norms of Ukraine ДБН В.2.6-98:2009 correlations of physical-mechanical descriptions of heavy concrete of classes B20…B60 with the purpose of analytical determination of corner of sliding ö and durability Rbtn. Cube durability Rbkn is certain by value Bi with normative confiding probabilityVbkni = (1 −1,64 × 0,135 × 0,01Bi ) . As a result of calculation have, according to the class of concrete, corner ф ≡ 65...69° , and value Rbtn, on the whole, coincided with normative for seven classes, and for the classesof B40 and B50 divergence made, in the quantitative measuring 0,05 MPa, and in a percent a bout 2 %. Taking into account the mixed character of destruction of concrete, the attempt of determination of resistance the cut of Rbsn is done for the concrete of middle durability on a formula Rbsn = Rbtn ⋅ tgф . In the total the results of our calculations practically coincided with information of early researches of V. A. Bushkov, V. Y. Rutgers and other.
Ecological aspects of recycling the polyethylene terephthalate waste materials
Authors: Arlamova N. T. , Burmistr M. V. , Khokhlova T. V. , Rozgon O. V. , Soroka M. L. 
Published: May 2023

The advantages and defects of modern technology treatment of polyethylene terephthalate (PETF) wastes, and amounts of the accumulation PETF-tares are analyses in article. Has been established that exploitative properties of experimental samples from secondary PETF, development by method compressed pressing, allowing their use in non-loading friction knots of the machines and mechanisms.
Comparative analysis of modulation and demodulation methods of the control signals of rail line
Authors: Goncharov K. V. 
Published: May 2023

Introduction: One of the ways of increasing the noise stability rail circuit is the use more informative waveform of control signal. Use in rail circuit modulated signals gives several informative selective traits in relatively narrow spectrum. The study of features of various modulation and demodulation methods with considering operating conditions of rail circuits is urgent. Purpose: the search for more informative forms of rail line control signal, the search for improved methods of signal processing of control current. Methods: For carrying out researches the method of signals decomposition in Fourier series and the simulation with the method of statistical tests have been sed. Results: Spectrum of frequency shift signal is wider than the spectrum of amplitude shift and phase shift signals by an amount equal to twice the frequency deviation. The research of correlation coherent and incoherent reception methods of rail line control signal has been carried out. In this case, we used the following models of interferences: white Gaussian noise, random pulse sequence and sinusoidal interference. It has been found that the transition from amplitude to frequency shift keying reduces signal/noise ratio by 2...4 dB, depending from the signal level and the type of noise. Losing amplitude shift keying receiver compared with the phase shift keying receiver is 5...6 dB. Conclusions: The use of more advanced methods of modulation and demodulation improves noise stability of rail circuit. When using correlation methods reception phase shift keying provides the best noise stability, and amplitude – the worst.
Use of a hydraulic brake as a source of thermal energy for the railway rolling stock
Authors: Gabrinets V. A. 
Published: May 2023

Introduction: In this paper the braking issues of passenger trains which have a great speed and frequent stops are examines. Problem statement: These processes are ехpensive and have big energy losses. The proposed solution to the problem: The kinetic energy of braking prosses propose to turn into thermal energy of heating fluid. For this purpose special hydraulic brake is proposed. The brake is connected with the wheel carriage pairs. The process is based on the energy dissipation in liqid when the disks with spikes rotate in it. Because the real liquid has friction and viscosity, it will be heat up, when the mechanical parts of the hydraulic brake are moved in it. The design, operating principle and characteristics of the hydraulic brake are proposed. Transmission of kinetic energy of carriage motion to brake system executed by mechanical clutches. It connected with the wheel pair and transmitting the energy the wheels rotation to hydraulic brake discs. The cylindrical rods are installed on the discs. Rods location fits the profile of the curved centrifugal pump vanes. As result, the fluid heatind prosess by rotatinge discs with rods take place also at the same time with the liquid pumping through the inner volume of brake system.Conclusions: Affordable passenger carriage braking dynamic is achieved by varying the size and number of rods. The heated liquid may be subsequently used for household needs and for heating the passenger carriage.
Theoretical aspects and methods of the parameters identification of the electric traction system devices. The instantaneous powers method; series connection of elements
Authors: Mishchenko T. M. 
Published: May 2023

Introduction: By means of the mathematical or computer (imitating) modeling the emergency, especially stochastic, transient electromagnetic and / or electro energetic processes in the electric traction system of the alternating current should be investigated. It allows expanding the research opportunities, as well as simplifying and reducing the actual testing, because it permits the wide variation of values and parameters reality of the elements of electric power circuits in the traction system without considerable material costs. Purpose: For this purpose the mathematical model of the nonlinear dynamical system "traction substation – electric traction network – electric rolling stock» as a passive two-terminal network with the given input voltage and input current is proposed. Task: The identification problem of the device under study, therefore the two-terminal network, is the determination electrical parameters (active resistance to inductance and capacity) of the passive elements, which substitute the two-terminal network. The scheme of its substitution looks like the series connection of passive elements. Methodology: The method of solving this problem for the passive two-terminal network in the traction mode with alternating, nonsinusoidal, deterministic periodic input voltage and input current is proposed. The calculations are executed for the electric locomotives DS3 and 2ES5K. Results: The results for the parameters can be applied in the further calculations of the more complex electric traction systems of the alternating current.
Evaluation laterally loaded liquid of inhomogeneous trains at various mode of braking
Authors: Romanyuk Y. N. 
Published: May 2023

Problem statement. By means of mathematical modelling it is investigated longitudinal forces of non-uniform bulk trains at various ways of braking. Various schemes of formation of the bulk trains, consisting of four-axised and eight-axised tanks with various level of incomplete filling of transported liquid are considered. It is estimated the influence of level of filling of a copper of the tank by liquid on longitudinal forces of trains at braking. For the decision of the given problem the trains made from 30 four-axised and 30 eight-axised cars-tanks and one locomotive VL-8, located in the head of a train were considered. For the estimation of longitudinal forces emergency and full service braking at speeds of movement 30 km/h and 60 km/h on a horizontal site of a way were considered. At mathematical modelling it was supposed that tanks were filled by black oil in density ρ =0,99 t/m 3. Various variants of removal of the level free surface of liquid from the top internal surface of a copper of the tank were considered. The incomplete filling was accepted equal 0,4; 0,8; 1,2 metres. Scientific results. As a result of calculations diagrammes of distribution of the maximum longitudinal forces along the length of a train and brake ways for various schemes of formation and different level of incomplete filling of transported liquid have been received. Various braking of preliminary stretched and compressed trains are considered. Conclusions. The received results show that in need of driving the bulk non-uniform as cars-tanks (4- axised and 8- axised) trains their formation should be made with installation of eight-axised tanks in the first half of the structure.
Logistiks methods of resource management at repairs of the rolling-stock at the industrial enterprises
Authors: Kapitca M. I. , Gnenny N. V. , Pinchyk E. P. , Privalova L. V. 
Published: May 2023

In clause the methodical approaches to logistics methods of resource management of the industrial enterprises are considered at performance of repairs of the rolling-stock. The general(common) algorithm of increase of capacity of system of repair is offered on the basis of a choice of a rational sequence of realization of methods of management of its(her) resources.
Recommendation of RILEM TC 271-ASC: New accelerated test procedure for the assessment of resistance of natural stone and fired-clay brick units against salt crystallization
Authors: Lubelli B. , Rörig-Daalgard I. , Aguilar A. M. , Aškrabić M. , Beck K. , Bläuer C. , Cnudde V. , D’Altri A. M. , Derluyn H. , Desarnaud J. , Diaz Gonçalves T. , Flatt R. , Franzoni E. , Godts S. , Gulotta D. , van Hees R. , Ioannou I. , Kamat A. , De Kock T. , Menendez B. , de Miranda S. , Nunes C. , Sassoni E. , Shahidzadeh N. , Siedel H. , Slížková Z. , Stefanidou M. , Theodoridou M. , Veiga R. , Vergès-Belmin V. 
Published: May 2023

AbstractThis recommendation is devoted to testing the resistance of natural stone and fired-clay brick units against salt crystallization. The procedure was developed by the RILEM TC 271-ASC to evaluate the durability of porous building materials against salt crystallization through a laboratory method that allows for accelerated testing without compromising the reliability of the results. The new procedure is designed to replicate salt damage caused by crystallization near the surface of materials as a result of capillary transport and evaporation. A new approach is proposed that considers the presence of two stages in the salt crystallization test. In the first, the accumulation stage, salts gradually accumulate on or near the surface of the material due to evaporation. In the second, the propagation stage, damage initiates and develops due to changes in moisture content and relative humidity that trigger salt dissolution and crystallization cycles. To achieve this, two types of salt were tested, namely sodium chloride and sodium sulphate, with each salt tested separately. A methodology for assessing the salt-induced damage is proposed, which includes visual and photographical observations and measurement of material loss. The procedure has been preliminarily validated in round robin tests.
Phenotype differentiation of Capsicum annuum var. glabriusculum of three regions in Mexico and its relation to climate
Authors: Romero-Higareda César Enrique , Hernández-Verdugo Sergio , Pacheco-Olvera Antonio , Retes-Manjarrez Jesús Enrique , Osuna-Enciso Tomás , Valdéz-Ortiz Ángel 
Published: May 2023

Background: Populations of Capsicum annuum var. glabriusculum are found in a wide portion of the Mexican territory, and it is ancestor of many cultivated forms relevant for the Mexican diet.
Questions: What are the proportions of phenotypic and genetic variation distributed among its sampled regions, populations and within populations. How does the climate correlates to the population’s phenotypic variation.
Species: Capsicum annuum var. glabriusculum.
Study sites and years: 24 populations form three regions were sampled: Northwest, states of Sonora and Sinaloa; South: Oaxaca and Southeast Tabasco and Yucatán, in Mexico. The experiment was performed between years 2016 to 2018.
Methods: Fruits from single plants were collected in wild populations. Plants were grown in a greenhouse. Nested ANOVAS were performed to estimate phenotypic and genetic variance components for different spatial scales. Climate correlation was estimated through univariate and multivariate methods.
Results: 49.8 % of phenotypic variation was detected within families, 11.1 % among families (within populations), 21.3 % among populations and 17.6 % among regions. The genetic basis of phenotypic variation was 50.1% on average, for this genetic variation 34.2 % was found among regions, 39.4% among populations and 26.3 % within populations. Climate factors generated different patterns of correlations for vegetative, foliar and reproductive traits.
Conclusions: Northwest plants were shorth, with small leaves and large fruits, Southeast plants were tall, with large leaves and small fruits, South plants developed intermediate phenotypic traits. Climate explained a large proportion of phenotypic differentiation.
Diz Osteoartritinde COMP ve MMP-3 Düzeylerinin Radyografik ve Klinik Bulgularla İlişkisi
Authors: YILDIZ Vildan , GÖKÇE KUTSAL Yeşim , KARAHAN Sevilay , DİKMEN Zeliha Günnur , AYDINGÖZ Üstün 
Published: May 2023

Amaç:Osteoartrit, çoğunlukla dizleri etkileyen en yaygın eklem hastalığıdır. Son yıllarda, düşük dereceli kronik inflamasyonla seyreden multifaktöriyel bir hastalığın osteoartrit patogenezinde rol oynadığı düşünülmektedir. Bu çalışmanın amacı diz osteoartriti olan hastalarda hastalığın radyolojik evreleri ve hastanın günlük yaşam aktivite düzeyleri ile serum kıkırdak oligomerik matriks proteini (COMP) ve matriks metaloproteinaz-3 (MMP-3) düzeyleri arasındaki ilişkiyi araştırmaktır.
Materyal ve Metod:Seksen beş hasta Kellgren-Lawrence ölçeğine göre üç gruba ayrıldı. 1. grup Evre I, 2. grup Evre II/III ve 3. grup Evre IV hastalar dahil edildi. Hastaların günlük yaşam aktivitelerinde ağrı şiddetini ve fonksiyonel durumlarını değerlendirmek için Görsel Analog Skala (VAS), Western Ontario ve McMaster Üniversiteleri Osteoartrit İndeksi (WOMAC), Lequesne algofunctional diz indeksi ve Diz Yaralanması ve Osteoartrit Sonuç Skoru Kısa Formu (KOOS-PS) kullanıldı.
Bulgular:Her üç hasta grubunda da serum COMP ve MMP-3 düzeyleri benzer bulundu. Serum COMP düzeyleri ile VAS, Lequesne skorları arasında zayıf korelasyon saptandı. Serum MMP-3 düzeyleri ile VAS, Lequesne ve KOOS-PS arasında da zayıf bir korelasyon olduğu belirlendi.
Sonuç:Diz osteoartrit gruplarının farklı radyolojik evreleri ile günlük yaşam aktivitelerinde ağrı şiddeti ve fonksiyonel durum olan klinik parametreler ile serum COMP ve MMP-3 düzeyleri arasında anlamlı farklılık saptanmadı. Bu konuda daha büyük örneklem gruplarıyla yapılacak çalışmalara gereksinim vardır.
Hekimlerin Mültecilere Yönelik Sağlık Hizmetleri Hakkındaki Görüşleri ve Sağlık Hizmeti Sunumundaki Yaklaşımları
Authors: GÜNBEĞİ Meltem , SAZAK UYGUL Elif , TURLA Ahmet , AYDIN Berna 
Published: May 2023

Amaç: Sağlık hizmetine erişiminin en önemli komponentlerinden biri olan sağlık hizmeti yürütücüsü hekimlerin mültecilere verilen sağlık hizmeti hakkında görüş ve tutumlarının belirlenmesi ve elde edilen sonuçların sağlığa erişim hakkı çerçevesinde tartışılması amaçlandı.
Gereç ve Yöntem: Kesitsel nitelikteki çalışmada, çalışmanın amacına yönelik 32 sorudan oluşan bir anket formu hazırlandı ve 22.10.2018-22.01.2019 tarihleri arasında erişime açık olan ankete 571 hekim yanıt verdi. Verilerin analizi SPSS 21.0 paket programı ile yapıldı. Verilerin değerlendirilmesinde tanımlayıcı istatistiksel analiz kullanıldı.
Bulgular: Mültecilerin tüm sağlık hizmetlerine ücretsiz erişememesi gerektiğini düşünenlerin oranı %43,5 (n:248)’ti. Katılımcı hekimlerin %26,4 (n:151)’ü aynı klinik duruma sahip Türk vatandaşlarına mültecilere göre öncelik tanınması gerektiğini, %85,4 (n:485)’ü tıp eğitimi sırasında mülteci sağlığına yönelik eğitim almadığını, %40,2 (n:225)’si mülteci hastalardan hiçbir zaman ayrıntılı anamnez alamadığını ya da nadiren alabildiğini, %59,9 (n:343)’u mülteci hastaların vereceği tedaviyi düzgün kullanacağına inanmadığını, %14,6 (n:81)’sı mülteci hastalar ile diğer hastalarına aynı şekilde yaklaşmadığını belirtmiştir.
Sonuç: Hekimlerin mültecilerin sağlığa erişimlerine yönelik eksik bilgileri, iletişim sorunları ve ön yargıları uygulamada meslek etiğine aykırı yaklaşımlara sebep olabilmektedir. Hekimlerin, meslek etik kurallarına yönelik farkındalığı arttırılmalı, tıp eğitimleri müfredatlarına mülteci sağlığına yönelik daha fazla eğitim içeriği konulmalı ve sağlık sisteminde dezavantajlı gruplara yönelik planlı, uzun vadeli programlar yapılmalıdır.