bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fully implantable and battery-free wireless optoelectronic system for modulable cancer therapy and real-time monitoring
Authors: Kim Kiho , Min In Sik , Kim Tae Hee , Kim Do Hyeon , Hwang Seungwon , Kang Kyowon , Kim Kyubeen , Park Sangun , Lee Jongmin , Cho Young Uk , Lee Jung Woo , Yeo Woon-Hong , Jung Young Mee , Song Young Min , Yu Ki Jun 
Published: June 2023

Abstract
Photodynamic therapy (PDT) is attracting attention as a next-generation cancer treatment that can selectively destroy malignant tissues, exhibit fewer side effects, and lack pain during treatments. Although implantable PDT systems have recently been developed to resolve the issues of bulky and expensive conventional PDT systems and to implement continuous and repetitive treatment, they only focus on providing the function of cancer termination. In cancer treatment procedures, monitoring and treatment of cancer must be done simultaneously. Existing implantable PDT systems, however, are not able to perform multiple functions simultaneously, such as modulating light intensity, measuring, and transmitting tumor-related data. Furthermore, not only current PDT systems, but also most other existing portable cancer treating/monitoring systems provide only a single limited function, resulting in the complexity of cancer treatment. Here, we introduce a flexible and fully implantable wireless optoelectronic system capable of continuous and effective cancer treatment by fusing PDT and hyperthermia and enables tumor size monitoring in real-time. This system exploits micro inorganic light-emitting diodes (µ-LED) that emit light with a wavelength of 624 nm, designed not to affect surrounding normal tissues by utilizing a fully programmable light intensity of µ-LED and precisely monitoring the tumor size by Si phototransistor during a long-term implantation (2–3 weeks). The superiority of simultaneous cancer treatment and tumor size monitoring capabilities of our system operated by wireless power and data transmissions with a cell phone was confirmed through in vitro experiments, ray-tracing simulation results, and a tumor xenograft mouse model in vivo. This all-in-one single system for cancer treatment offers unprecedented opportunities to not only enable effective treatment of tumors located deep in the tissue but also enable precise and continuous monitoring of tumor size in real time.
Comparison of endoscopic sinus sampling versus intracranial sampling for microbiological diagnosis of intracranial infection in children: A case series and literature review
Authors: Kameda-Smith Michelle Masayo , Mendoza Maya , Brown Li-An , Hartley John , Aquilina Kristian , James Greg , Jeelani Owase Noor , Silva Adikarige Haritha Dulanka , Thompson Dominic , Tisdall Martin , Tahir M Zubair , Hatcher James 
Published: June 2023

Abstract
Introduction
Intracranial infection is often associated with contiguous sinus infection, with Streptococcus intermedius being the most common pathogen. Microbiological assessment is possible via sinus or intracranial sampling. Whilst a sinus approach is minimally invasive it is not clear whether this yields definitive microbiological diagnosis leading to optimised antimicrobial therapy and avoidance of intracranial surgery.
Methods
Retrospective review of a prospectively collected electronic departmental database identified patients between 2019–2022. Further demographic and microbiological information obtained from electronic patient records and laboratory management systems.
Results
Thirty-one patients were identified with intracranial subdural and/or epidural empyema and concurrent sinus involvement during the 3-year study period. Median age of onset was 10 years with a slight male predominance (55%). All patients had intracranial sampling with 15 patients undergoing sinus sampling in addition. Only 1 patient (7%) demonstrated identical organism(s) grown from both samples. Streptococcus intermedius was the most common pathogen in intracranial samples. Thirteen patients (42%) had mixed organisms from their intracranial cultures and 57% of samples undergoing bacterial PCR identified additional organisms, predominantly anaerobes. Sinus samples had a significant addition of nasal flora and Staphylococcus aureus which was rarely grown from intracranial samples. Of concern, 7/14 (50%) of sinus samples did not identify the main intracranial pathogen diagnosed on intracranial culture and additional PCR. Literature review identified 21 studies where sinus drainage was used to treat intracranial empyemas, with only 6 authors reporting concurrent microbiology results. This confirmed our cohort to be the largest comparative study in the current literature. No centre has observed a greater than 50% concordance in microbiological diagnoses.
Conclusion
Endoscopic sinus surgery may have therapeutic benefit, but it is not an appropriate approach for microbiological diagnosis in paediatric subdural empyemas. High rates of contaminating nasal flora can lead to misdiagnosis and inappropriate treatment. Routine addition of 16S rRNA PCR to intracranial samples is recommended.
Development and psychometric properties of a medication information literacy scale for Chinese pregnant women
Authors: Li Su-ya , Guo Jin-Yi , Zhou Jie , Shen Quan , Niu Shu-Ya , Wang Lan , Chen Hui-Jun , Ouyang Yan-Qiong , Redding Sharon R. 
Published: June 2023

Abstract
Background
Pregnant women are in a unique physiological state and the safety of medication is an important issue related to maternal and infant health. With the increasing variety of information resources, the ability of pregnant women to correctly understand and make decisions about medication information depends upon their level of medication information literacy. However, currently, there is no valid and reliable instrument to measure this concept. The purpose of this study was to develop a medication information literacy scale for use in Chinese pregnant women and to measure their medication information literacy.
Methods
Under the guidance of the Ellis’ Information-Seeking Model and the Comprehensive Model of Information Seeking, preliminary items were developed through a literature review, expert consultation and modification. Following a pilot study, items were selected or revised using item discrimination, item correlation analysis and feedback from the participants. The final version of the medication information literacy scale was reviewed by 731 women to establish reliability and validity.
Results
The final scale consisted of five domains with 22 items. The Cronbach’s α coefficient was 0.871 and test-retest reliability was 0.870. Total explained variation was 64.642%. The scale demonstrated good validity (χ2/df = 1.999, GFI = 0.899, AGFI = 0.871, SRMR = 0.046, IFI = 0.926, RMSEA = 0.054, CFI = 0.925, and TLI = 0.913). In a formal survey of pregnant women, only 27.9% of pregnant women had adequate medication information literacy.
Conclusion
The medication information literacy scale demonstrates good reliability and validity, and can be used to assess medication information literary of pregnant women in Chinese context, thus leading to targeted interventions for this unique population.
Exposure, distribution, and ecological risk of four new bisphenol analogs in the typical lake region of Taihu Lake
Authors: Han Ying , Liu Yuxuan , Rong Xiaolong , wang Mingxin , Xue Yingang , Dai Hao , Jiang Haixia 
Published: June 2023

Abstract
The development of the industrial economy in Taihu Lake has led to increased levels of bisphenol compounds (BPs), which are difficult to degrade and highly toxic, making them a research focus. This study aimed to determine the occurrence, sources, and ecological risks of bisphenol Z (BPZ), bisphenol C (BPC), bisphenol F (BPF), and bisphenol S (BPS). Surface water and sediment samples were collected and analyzed, revealing average BPs concentrations of 1227 ng/L and 11 ng/g (dry weight), respectively. BPS had the highest detection rate among the four BPs, followed by BPF. Pollutant levels were found to increase upstream and decrease downstream. In wild fish, the pollutants were found to be concentrated in the muscle, gill, liver, kidney, and brain tissues, indicating short-term exposure. Correlation and stable isotope analyses showed that BPF and BPS had similar origins, and sediments were found to be the primary source of the pollutants. Ecological and human health risk assessments showed low-risk levels, but the risks are still increasing and require attention. This study provides valuable information for the management and control of BP pollution in Taihu Lake.
Unravelling the role of Exosomes as early non-invasive predictors of disease state in Glioblastoma
Authors: Upadhyay Vinal , Bhadresha Kinjal , Rawal Rakesh 
Published: June 2023

Abstract
Background
Gliobastoma are the malignant grade 4 astrocytic tumours, which accounts for the major cause of recurrence or death amongst all the brain tumours. The biology to pathophysiology of the tumour being complex, the search for specific differential markers always remains the need of an hour for disease treatment and monitoring. Liquid biopsy approach has open newer avenues to study and regulate the disease in a non-invasive manner. The study focuses to find the some newer regulatory genes by a liquid biopsy approach.
Methodology:
Meta-analysis was carried for the already published datasets pertaining to Glioblastoma by Gene Spring software. The top listed genes were validated in tissue and exosomes of the patients. Sixty tissue samples and 30 blood (serum) samples were collected from the glioma patients. Expression analysis was carried out by quantitative real time PCR. The results were statistically analyzed using SPSS 16.0 and PRISM software.
Results
Meta-analysis fetched the top 9 highly upregulated genes inclusive of CD44, VEGFA, TGFβ1, THBS1, SERPINE1, TAGLN2, ATF3, FOSL2, FABP5. Amongst these genes, CD44, VEGFA, TGFβ1, THBS1 and SERPINE1 showed the significant differential expression between low grade and high grade gliomas tissue samples. These five significant genes when analysed in the exosomal RNA, prominent differential expression was observed.
Conclusion
The study conclusively shows that CD44, VEGFA, TGFβ1, THBS1 and SERPINE1 could collectively work as hub genes to differentiate high grade gliomas from low grade tumours. Moreover, blood serum could serve as a better liquid biopsy marker in case of high infiltrating GBM tumours.
Nonlinear Dynamics manuscript No. (will be inserted by the editor)
Prescribed-time stabilizing strategy for a class of time-varying nonlinear systems and its application to pendulum system
Authors: Li Jiao-Jiao , Sun Zong-Yao , Wen Changyun , Chen Chih-Chiang 
Published: June 2023

Abstract
In this paper, a new scheme is proposed to stabilize a class of nonlinear systems within a prescribed time, mainly motivated by the following two unsolved intricate problems: i) the singularity caused by infinity control magnitudes at the prescribed time instant and ii) the lack of formulating/manipulating state responses after the prescribed time. Under the proposed scheme,
an exquisite controller is constructed by entailing both the state scaling approach and a finite-time stabilizing procedure. It is shown that the obtained control is well defined with bounded magnitude on the whole time horizon and ensures the existence of the solutions of the closed-loop system. Superior to the existing prescribed time stabilization results, the proposed method
is capable of ensuring that the states of the closed-loop system converge to a prescribed compact set within the prescribed time, stay inside it thereafter and perform nite-time convergence eventually. A simulation example is presented to illustrate and verify the effectiveness of the proposed approach.
Methane-hydrogen-rich fluid migration triggers seismic failure in subduction at forearc depths
Authors: Giuntoli Francesco , Vitale-Brovarone Alberto , Menegon Luca , Siron Guillaume , Cognigni Flavio , Leroux Hugues , Compagnoni Roberto , Rossi Marco 
Published: June 2023

Abstract
Metamorphic fluids and deformation zones are fundamental carriers of carbon from the deep Earth to shallower reservoirs. It is well established that water weakens rocks and contributes to trigger seismicity. Conversely, the potential effects of carbon-rich aqueous fluids on deep-seated rocks remain little studied. Some of these fluids may be reduced and transport energy sources such as natural H2 and CH4. Mechanisms and pathways capable to transport these deep energy sources towards shallower reservoirs, where they may be used by microbial life in the subsurface biosphere, remain unidentified. Here we present direct geological evidence of seismic failure of mechanically strong rock types due to the accumulation of CH4-H2-rich fluids at deep forearc depths, which ultimately reached supralithostatic pore fluid pressure. These fluids originated from adjacent reduction of carbonates by H2-rich fluids during serpentinization at eclogite-to-blueschist-facies conditions. Thermodynamic modelling predicts that the production and accumulation of carbon-rich fluids can produce overpressure much more easily than C-poor aqueous fluids, and that CH4-H2-rich fluids are more favourable to produce overpressure than CO2-rich ones. This study provides tangible evidence for the migration of deep Earth energy sources along tectonic discontinuities and suggests causal relationships with brittle failure of hard rock types that may trigger seismicity at forearc depths.
Bilateral Cowper’s Syringocele in a Teenager: A Clinical Case
Authors: Osipov Igor , Lebedev Dmitry , Uzintseva Anastasiya , Sidorova Nadezhda 
Published: June 2023

Abstract
Background: Cystic enlargement of the excretory ducts of the bulbourethral glands (Cowper’s gland syringocele) (CGS) is a rare urethral pathology. This condition was first described in 1976. No more than 150 cases of CGS have been described in the literature, the vast majority of them in children. Bilateral CGS was mentioned in 8 cases. Descriptions of bilateral CGS with connection of cavities through the medial septum have not been found in the literature. We report a successful minimally invasive treatment of bilateral open CGS in an adolescent.
Case presentation: A 16-year-old teenager came to the clinic with complaints of painful urination and post-micturition drip of urine. Sick for 2 years. Examination revealed bilateral CGS.
Surgical treatment was performed: endoscopic resection of the roof and septum of the CGS chambers. At the control examination after 7 months, the complaints stopped, there was a complete normalization of urodynamics and recovery of the patient.
Conclusion: Urethroscopy, MRI and retrograde urethrography allowed the diagnosis. Minimally invasive surgical treatment of dual chamber CGS was successful and had no complications.
Predicting fertilizer concentration for precision irrigation under mixed variable-rate fertigation using machine learning: a case study of combined fertilization with dipotassium hydrogen phosphate and potassium chloride
Authors: Wu Menglong , Xiong Jiajie , Li Ruoyu , Dong Aihong , Lv Chang , Sun Dan , Abdelghany Ahmed Elsayed , Zhang Qian , Wang Yaqiong , Niu Wenquan 
Published: June 2023

Abstract
Variable precise fertigation is critical to precision irrigation. The question of how to monitor the combination of fertilizer concentration and variable irrigation components as accurately as possible is challenging. The primary goal of this study is to develop accurate prediction models integrated with machine learning (ML) to predict the concentration of each type of fertilizers in mixed variable-rate fertigation used for precision irrigation. First, the feasibility of predicting of fertilizer concentration by monitoring physical parameters such as electrical conductivity (EC), acidity (pH) and temperature in mixed variable-rate fertigation was confirmed. 11 selected ML algorithms were applied to develop regression models that can accurately predict each fertilizer concentration of the mixed fertilizer compared to the classical multivariate linear regression (MLR). In addition, cubic spline interpolation (CSI) was used to densify the data sets, and K-fold cross-validation was employed to fairly evaluate the generalization ability (GA) of these models. The statistical and diagnostic analyzes revealed the superiority of ML especially SVM, KNN, ETs, and MLP over MLR in predicting each type of fertilizer concentration in mixed variable-rate fertigation with an R2 range of 0.9499 ~ 0.9970 and an RMSE range of 0.0852 ~ 0.4434 g/L, better than MLR with an R2 range of 0.8544 ~ 0.9425 and an RMSE range of 0.3752 ~ 0.7559 g/L. Moreover, the contribution of CSI to the modeling accuracy was confirmed, but the sensitivity of the models to EC and pH increased with the data from CSI and the tuning of the model hyper-parameter. Overall, the feasibility and performance of the ML models for predicting mixed fertilizer concentration by monitoring temperature, EC, and pH indicate that the presented ML models have significant application potential for irrigation and fertilization monitoring management of mixed variable-rate fertigation in precision irrigation with high-precision sensor technology.
Annual and periodic variations of particulates and selected gaseous pollutants in Astana, Kazakhstan: Source identification via conditional bivariate probability function
Authors: Agibayeva Akmaral , Karaca Ferhat , Guney Mert , Bex Torekhan , Avcu Egemen 
Published: June 2023

Abstract
The degradation of air quality remains one of the most pressing environmental issues as exposure to air pollutants is extensively associated with various health problems including respiratory and cardiovascular diseases. The present study aims to (1) reveal the annual and periodic variations of PM2.5, total suspended particles (TSP), and selected gaseous pollutants (SO2, CO, NO2, HF) in Astana, Kazakhstan by analyzing two-year air pollution monitoring data (October 2018-September 2020) divided into 2 study cycles (October 2018-September 2019 and October 2019-September 2020, respectively); and to (2) identify potential air pollution sources in the region using conditional bivariate probability function (CBPF). Annual concentrations of PM2.5 and other gaseous pollutants were generally high, exceeding World Health Organization air quality guidelines and nationally adopted air quality standards; with heating periods (October - April) characterized, on average, by higher ambient concentrations than non-heating periods. Notably, the concentrations of observed pollutants were higher during the 2018-2019 study cycle than in 2019-2020. Obtained results are useful for subsequent estimation of the burden of respiratory and cardiovascular diseases in the region. The CBPF analysis of PM2.5 data suggested a general contribution of the coal-fired power plants as well as residential heating activities to the air pollution in the city, while a joint contribution of vehicular emissions and power plant activity was identified as the pollution source of SO2. Control measures for PM2.5 and SO2 emissions specifically arising from the coal-fired power plants need to be urgently implemented.
Proinflammatory impact of putative viral-specific CD8+ T cells infiltrating new-onset seropositive rheumatoid arthritis synovium
Authors: Wehr Pascale , Nel Hendrik , Zhou Chenhao , Andoniou Christopher , Schuster Iona , Yunis Joseph , Gras Stephanie , McGuire Helen , Weedon Helen , Small Annabelle , Lowe Katie , Cai Benjamin , Rae James , Parton Robert , Farrell Helen , Mehdi Ahmed , Steptoe Raymond , Degli-Esposti Mariapia , Yu Di , Wechalekar Mihir , Thomas Ranjeny 
Published: June 2023

Abstract

New-onset HLA-DR-associated anti-citrullinated protein autoantibody (ACPA)+ rheumatoid arthritis (RA) synovial tissue (ST) contains highly-expanded TCR-αβ clonotypes, some viral-antigen-reactive. However, it is unknown how viral-specific T-cells sustain ACPA+ RA. We studied paired peripheral blood (PB) and ST TCR repertoires in drug-naïve ACPA+ HLA-DRB1*04:01+ diffuse-myeloid RA ST pathology. To model effects of viral infection, we induced ovalbumin antigen-induced arthritis (AIA) in mice with latent murine-cytomegalovirus or recovered from acute lymphocytic-choriomeningitis virus. We show that most clonally-expanded CD8+ T cells had polyfunctional TNF+IFNγ+ cytotoxic T-lymphocyte (CTL) signatures. Transcriptomic profiles of ST CD4+ T-cell clonotypes were Th2-like and IL-6-signaled central memory-like. CMV-specific tetramers confirmed in-silico prediction of viral-epitope recognition by CTL. Perivascular GZMB+CD8+ T cells co-localized with CD4+ T-cells, dendritic cells, fibroblasts and IL-6. After viral infection, AIA severity increased with enhanced viral and ovalbumin-specific TNF+IFN-γ+ T-cell cytokines, suggesting that in the diffuse-myeloid rheumatoid-synovial perivascular niche, polyfunctional bystander-CTL reinforce myeloid- and CD4+ T-cell activation.
Multi-type Features Graph Neural Networks for Cocrystals Prediction using API-Coformers Interactions
Authors: Mswahili Medard Edmund , Jo Kyuri , Lee SeungDong , Jeong Young-Seob 
Published: June 2023

Abstract
Active pharmaceutical ingredients (APIs) have gained direct pharmaceutical interest, along with their in vitro properties, and thus utilized as auxiliary solid dosage forms upon FDA guidance and approval on pharmaceutical cocrystals as a potential and attractive route for drug substance development. In this study, we implemented graph neural networks to predict the formationof cocrystals using our first created API-co-formers interactions graph dataset. We further compared our work with previous studies that implemented descriptor-based models (e.g., random forest, support vector machine, extreme gradient boosting,and artificial neural networks). All built graph-based models show compelling performance accuracies (i.e., 91.36, 94.60, and 95.95% for GCN, GraphSAGE, and R-GCN respectively). Furthermore, R-GCN prevailed among the built graph-based models due to its capability to learn the topological structure of the graph from the additionally provided information (i.e., non-ionic andnon-covalent interactions or link information) between APIs and coformers.
Self-reported Determinants for Subjective Financial Distress: A Qualitative Interview Study with German Cancer Patients
Authors: Züger Andrea , Mathies Viktoria , Mehlis Katja , Pauge Sophie , Richter Luise , Surmann Bastian , Ernst Thomas , Greiner Wolfgang , Menold Natalja , Winkler Eva C. 
Published: June 2023

Abstract
Purpose. Patient-reported financial effects of a tumor disease in a universal healthcare setting are a multidimensional phenomenon. Actual and anticipated objective financial burden caused by direct medical and non-medical costs as well as indirect costs such as loss of income, can lead to subjective financial distress. To better understand the reasons for subjective financial distress and to identify aggravate (obstacles) and preventive (resources) determinants, the present study inquires how cancer patients interpret and explain the level of subjective distress due to financial consequences of their disease.
Methods. Semi-structured interviews with n=18 cancer patients were conducted between May 2021 and December 2021. Patients were recruited based on a purposive sampling strategy in outpatient and inpatient settings. The interviews were audio-recorded, transcribed verbatim, and analyzed using qualitative content analysis.
Results. When explaining the degree of their subjective distress, interviewees refer to both distress-preventing and distress-increasing influencing determinants. Distress-preventing factors are material, social and systemic resources such as access to social and health care service; cognitive coping strategies; personal character traits and change of attitude. Distress was increased by administrative hurdles and expected objective financial burden.
Conclusion. Subjective financial distress depends on material, social, systemic and personality-specific determinants. To address them, not only individual counselling is needed, but also socio-politicalchanges.
Trial registration number NCT05319925