bluuebunny/crossref_metadata_2025_split huggingface dataset:
¿Son los anticuerpos IgG e IgM contra los antígenos S y N del SARS-CoV-2 siempre predictores de infección previa por SARS-CoV-2?
Authors: Lippi Giuseppe , Henry Brandon M. , Pighi Laura , De Nitto Simone , Salvagno Gian Luca 
Published: May 2023

Resumen

Objetivos
Evaluamos si los inmunoensayos con anticuerpos IgG e IgM contra las proteínas spike (S) y nucleocápside (N) del SARS-CoV-2 detectan infecciones previas por SARS-CoV-2.

Métodos
Analizamos una cohorte de profesionales sanitarios que había completado el ciclo de vacunación. Desde 2020, y cada 2–4 semanas, se les realizaron revisiones médicas y pruebas moleculares para diagnosticar una posible infección por SARS-CoV-2. Se extrajeron muestras de sangre venosa para medir los niveles de anticuerpos contra el SARS-CoV-2 con los ensayos MAGLUMI® 2019-nCoV lgG y 2019-nCoV lgM CLIA dirigidos a las proteínas S y N del SARS-CoV-2.

Resultados
En total, la prueba RT-PCR fue positiva para SARS-CoV-2 en 31 (58,5 %) sujetos (el resultado fue positivo una vez en 24 sujetos y dos veces en 7). No se observó una relación directa entre los niveles de anticuerpos IgM contra S y N del SARS-CoV-2 y la positividad de la prueba molecular. El análisis de regresión univariante reveló una relación estadísticamente significativa entre los anticuerpos IgG contra S y N del SARS-CoV-2 y una prueba molecular positiva (r=0,33; p=0,015) y el número de pruebas moleculares positivas (r=0,43; p=0,001). Sin embargo, no se observó correlación con el número de dosis de la vacuna (r=−0,12; p=0,392). La significación se mantuvo en el análisis de regresión lineal (p=0,029 y p<0,001, respectivamente) tras controlar el efecto del sexo, edad, índice de masa corporal y dosis de la vacuna. En el análisis de la curva ROC, los IgG contra S y N del SARS-CoV-2 predijeron significativamente la positividad de la prueba molecular (AUC, 0,69; IC95 %; 0,55–0,84). El mejor valor umbral fue 0,05 AU/mL, con una precisión del 67,9 %, una sensibilidad del 0,97, y una especifidad de 0,27.

Conclusiones
Aunque los anticuerpos IgG contra S y N del SARS-CoV-2 proporcionan información útil para identificar infecciones previas por SARS-CoV-2, se debería emplear un valor umbral inferior al de la reactividad de la muestra. Los anticuerpos IgM contra S y N del SARS-CoV-2 no son válidos para tal fin.
An Autobiography of Childhood: Anatoly Kuznetsov’s Babi Yar as Bildungsroman
Authors: Balina Marina 
Published: May 2023

Abstract
This article represents an attempt to read Anatoly Kuznetsov’s Babi Yar: A Document in the Form of a Novel in its complete and uncensored version (published 1970) as a novel of education. Critical interpretation of this text has been dominated by the story of the mass shootings of the Jewish population witnessed by the adolescent Tolya, with the youngster’s own story often relegated to the background. But the analytic framework of the Bildungsroman makes it possible to see how, in addition to serving as a testimonial of the “Holocaust by Bullets,” the book demonstrates the full extent of the deformation of a child under conditions of war and occupation. The theoretical apparatus of the analysis is largely based on research in narratological theory (Shlomith Rimmon-Kenan). Discussion of the structural features of an autobiography of childhood also draws on Kate Douglas’s studies on autobiography, trauma, and memory. As a process of socialization, Bildung in Babi Yar turns into an anti-Bildung of adolescence: Kuznetsov’s novel shows how the experience of war deforms the personality on a variety of perceptual levels—optical, olfactory, haptic, and sonic.
Interpreting Interpretation in Private Law
Authors: Zanitelli Leandro Martins 
Published: May 2023

Abstract
The article addresses the following question: why do we interpret private law? My aim is, first of all, to make use of the theory of interpretation presented by Ronald Dworkin in Justice for Hedgehogs (Dworkin 2011) to emphasize the methodological importance of this issue. Second, the article casts doubt on the thesis that different interpretations of private law – for example, the so-called structuralist interpretations and instrumentalist interpretations such as the economic analysis of law – are rival interpretations. Like Dworkin, I argue that it is our interpretive responsibilities that define whether or not two interpretations of the same object should be treated as rivals. These responsibilities, in turn, are measured in light of the purpose of the interpretation. The interpretation of private law is a peculiar case of legal interpretation because it is not eminently concerned with determining the content of that law. On the other hand, if justification is the point of interpreting private law, then there seems to be no reason why different interpretations should necessarily be interpretations in competition with each other. The justification of private law may depend on a plurality of normative injunctions being met, and the features by which private law satisfies these injunctions can be highlighted sometimes by one interpretation, sometimes by another.
Giving voice to the Csángó figure: participation roles and the production of belief in language revitalisation
Authors: Bodó Csanád , Fazakas Noémi 
Published: May 2023

AbstractLanguage revitalisation gives voice to those who participate in it. But it is not always clear whose voice the participants make heard. It is also not straightforward who hears and wants to listen to the voices that are raised during language revitalisation. In this article, we present a language educational programme which aims to give voice to the participants of the Moldavian Hungarian (also calledCsángó) language revitalisation in North-East Romania. Applying the Goffmanian participation framework, we demonstrate that the participants of the programme collaborate in giving voice to a Csángó-speaking figure while covertly performing different roles. Drawing on our linguistic ethnographic research, we point out how this institutionalised participation framework promotes the achievement of one of the objectives of language revitalisation: the restoration of past language practices. Nevertheless, it also creates an obstacle to another: to the way that the speakers of this language can have a voice worth hearing. The analysis highlights the tensions of institutionalising a participatory framework in language revitalisation, which aims to produce the belief in a Csángó figure representing the essential link between language and (national) community.
Shear strength behavior of organic soils treated with fly ash and fly ash-based geopolymer
Authors: Ameen Sarah K. , Abdulkareem Ahmed H. , Mahmood Nabeel S. 
Published: May 2023

AbstractOrganic soil is a problematic soil that needs to be treated before construction because of the low shear strength and high compressibility. Using by-product materials, such as fly ash (FA), to improve soils is a cost-effective and sustainable procedure. Because treatment with FA may lead to reduce shear strength, a FA-based geopolymer was used with a cohesive organic soil to substitute the reduction in strength. A series of unconfined compressive strength tests (UCS) were conducted on compacted specimens treated with FA and geopolymer. The geopolymer was produced by adding sodium hydroxide to activate the FA. Different levels of FA content, curing period, and temperature were applied to the specimens. The results indicate that for the FA treated specimens, the UCS decreased as the FA increased. For the geopolymer-treated specimens, as FA percentage in the geopolymer increased, the UCS increased and the axial strain at failure decreased. The optimum content of FA, in the geopolymer, was 20%, and the highest UCS was achieved at a curing period of 28 days at a temperature level of 65°C. Based on the obtained results, FA-based geopolymer can effectively be used to improve the strength of organic soils.
Enhancing the ability of rice to adapt and grow under saline stress using selected halotolerant rhizobacterial nitrogen fixer
Authors: Simarmata Tualar , Setiawati Mieke Rochimi , Fitriatin Betty Natalie , Herdiyantoro Diyan , Khumairah Fiqriah Hanum 
Published: May 2023

Abstract
Salinity stress has become the major devastating constraint for rice growth. Halotolerant rhizobacterial nitrogen fixer (HRNF) was investigated for increasing the nitrogenase activity (NA), organic acid (OA), gibberellic acid (GA), and indole 3-acetic acid (IAA) productions, seedling growth, and rice yield. Six N fixers were isolated using Ashby’s (Ab1, Ab2, and Ab3) and Okon’s media (Az1, Az2, and Az3). Furthermore, bioassay was carried out using rice seedling grown on nitrogen-free medium. The Ab3 and Az2 isolates were selected and biomolecularly identified as Pseudomonas stutzeri and Klebsiella pneumoniae, respectively. These selected bacteria were used as active ingredients for Halotolerant rhizobacterial inoculant (HRI) dosage trials (0, 500, 1,000, and 1,500 g ha−1) on simple pot experiments. The Az group isolates had 3–5 times higher ability in fixing N and producing OA, GA, and IAA than the Ab group isolates. Furthermore, N-uptake, number of panicles, filled grain, and the rice yield of HRI treated pots were significantly increased. Application of 1,000–1,500 g HRI ha−1 had resulted in a significant increase in the yield of rice grain (26.10–28.27 g plant−1 or 15.4–25.09%) which was higher than the control. This result concludes that HRI could contribute in enhancing the ability of rice to adapt and grow under saline stress.
Real-time image defect detection system of cloth digital printing machine
Authors: Liu Hongliang 
Published: May 2023

Abstract
In order to solve the surface defects such as white silk, spots and wrinkles in the process of digital printing, a surface defect detection system for printed fabrics based on accelerated robust feature algorithm was proposed. Image registration is mainly carried out through accelerated robust feature (SURF); bidirectional unique matching method is adopted to reduce mismatch points, achieve accurate image registration, and extract defect information through differential algorithm. The performance of the improved surfing algorithm is verified by using multiple images. The experimental results show that compared with the traditional template matching method, the detection accuracy of the system detection algorithm is 12% higher, and the average time is 42.81 ms shorter than the traditional template matching method. Experiments show that the improved surfing algorithm has short time and high precision. The system can meet the actual production needs. The new system can detect surface defects on printed fabrics with an accuracy of 98%. Conclusion: The algorithm has higher detection rate and faster detection speed, which can meet the needs of practical industrial applications.
Metal-centric organic compounds: boon to third-order nonlinear optical applications
Authors: S Shakeel Nawaz , S Ranganatha , S Supriya , Ramakrishna Dileep 
Published: May 2023

AbstractIn the recent past the molecular engineering of coordination metal complexes has attracted new interest in the field of nonlinear optics (NLO), which find their applications in optoelectronics and optical data storage technology it is the transition metal along with the organic moieties that induce the control over the optical nonlinearity these properties of the materials not only enhance the intensity but also have a drastic effect on the polarization of incident laser light. This is an important criterion for all-optical switching applications. Coordination metal complexes are a very good target to aim at because of their robustness, physical and chemical stability, and other variable degrees that lead to an increment in NLO responses, most importantly all these properties can be either manipulated or tailored or tunable according to the requirement. Apart from the metal center, these molecules acting as legend must be chromophoric with donor-acceptor nature. In these molecules, the NLO response is intrinsically based on the ‘push-pull’ mechanism of the electrons. Obviously to these molecules, when a metal is in contact, the electronic push-pull mechanism alters rendering the molecule non-symmetric. This review article mainly concentrates on small mononuclear metal complexes for NLO application.
Comparison of the effectiveness of eHealth self-management interventions for pain between oncological and musculoskeletal populations: a systematic review with narrative synthesis
Authors: Evenepoel Margaux , Van Dijck Sophie , Meeus Mira , Dams Lore , Haenen Vincent , Devoogdt Nele , Roussel Nathalie , De Groef An 
Published: May 2023

Abstract

Objectives
The aim of this systematic review is to compare the effectiveness of eHealth self-management interventions on pain intensity between oncological and musculoskeletal populations and to examine barriers and facilitators of the use of eHealth self-management tools.

Content
In March 2021, a systematic search of the literature was conducted using the databases PubMed and Web of Science. Studies that investigated the effect of eHealth self-management interventions on pain intensity in an oncological and/or a musculoskeletal population were included.

Summary
No study was found with a direct comparison of the two populations. Of the ten included studies, only one (musculoskeletal) found a significant interaction effect in favor of the eHealth program and three (musculoskeletal and breast cancer) showed a significant time-effect of the eHealth intervention. In both populations user-friendliness of the tool was considered as a facilitator, the length of the program and the lack of an in-person session as barrier. Due to the absence of a direct comparison, no conclusion can be made on how the effectiveness differs between both populations.

Outlook
Further research should incorporate patient-experienced barriers and facilitators and there is a high need of studies making the direct comparison of the effect of an eHealth self-management intervention on pain intensity in an oncological vs. a MSK population.
Relationship between a Layered Geomembrane–Geotextile System and Constituent Materials in a Multiaxial Tension Test
Authors: Xue Xia , Li Wang-Lin , Wei Ru-Chun , Yang Zhe , Wang Wan-Sheng 
Published: May 2023

Abstract
Layered geomembrane–geotextile systems (LGGSs) are used extensively worldwide. To increase strength, geomembranes are becoming thicker and geotextiles are becoming heavier. It is more challenging to obtain LGGS strength through laboratory tests, especially multiaxial tension tests. To address this problem, the relationships between LGGSs with different combinations and constituent materials were investigated using a multiaxial tension test and theoretical analysis. According to these relationships, when the LGGS and the constituent materials deform to an arc of a sphere because of the pressure applied under the membrane perpendicular to the surface of the specimen, the lowest geotextile (or two layers of continuous geotextile) in contact with the pressure medium in the LGGS can be considered an ineffective layer in multiaxial tension deformation, while the other layers are effective layers. The pressure of an LGGS at different deformations is the total of the pressure of each effective constituent material at corresponding deformations, and the stress within the cross-section of the LGGS at different strains is equal to the sum of the product of the stress of each effective constituent material at corresponding strains and its thickness percentage. With this relationship, we contribute to multiaxial tension mechanical characteristic applications by calculating the multiaxial tensile strength of LGGSs and facilitating material selection in engineering design.
Experimental Study on Uplift Behavior of Two-Plate Horizontal Anchors in Sand
Authors: Zhang Xin , Liu Mingliang , Jiang Tong 
Published: May 2023

Abstract
An experimental study on sand deformation around two-plate anchors connected to one shaft was conducted by using the digital image correlation technique to investigate load–displacement response and deformation fields in various embedment depth, plate spacing, and relative density configurations. A test setup comprising a camera, loading frame, and computer was developed to measure the uplifting load and displacement and to capture pictures during anchor uplifting. The uplift load of the top and bottom plates was observed to be characterized by asynchrony and a “relay” phenomenon. The deformation fields between the top and bottom plates also illustrated the “relay” phenomenon. Based on the experimental results, three failure models (shallow, deep, and composite failure) are proposed to describe the degree and the extent of soil shear mobilization around the two-plate anchors.
Posterior Parietal Cortex Plays a Causal Role in Abstract Memory-Based Visual Categorical Decisions
Authors: Zhou Yang , Zhu Ou , Freedman David J. 
Published: May 2023

Neural activity in the lateral intraparietal cortex (LIP) correlates with both sensory evaluation and motor planning underlying visuomotor decisions. We previously showed that LIP plays a causal role in visually-based perceptual and categorical decisions, and preferentially contributes to evaluating sensory stimuli over motor planning. In that study, however, monkeys reported their decisions with a saccade to a colored target associated with the correct motion category or direction. Since LIP is known to play a role in saccade planning, it remains unclear whether LIP's causal role in such decisions extend to decision-making tasks which do not involve saccades. Here, we employed reversible pharmacological inactivation of LIP neural activity while two male monkeys performed delayed match to category (DMC) and delayed match to sample (DMS) tasks. In both tasks, monkeys needed to maintain gaze fixation throughout the trial and report whether a test stimulus was a categorical match or nonmatch to the previous sample stimulus by releasing a touch bar. LIP inactivation impaired monkeys' behavioral performance in both tasks, with deficits in both accuracy and reaction time (RT). Furthermore, we recorded LIP neural activity in the DMC task targeting the same cortical locations as in the inactivation experiments. We found significant neural encoding of the sample category, which was correlated with monkeys' categorical decisions in the DMC task. Taken together, our results demonstrate that LIP plays a generalized role in visual categorical decisions independent of the task-structure and motor response modality.SIGNIFICANCE STATEMENTNeural activity in the lateral intraparietal cortex (LIP) correlates with perceptual and categorical decisions, in addition to its role in mediating saccadic eye movements. Past work found that LIP is causally involved in visual decisions that are rapidly reported by saccades in a reaction time based decision making task. Here we use reversible inactivation of LIP to test whether LIP is also causally involved in visual decisions when reported by hand movements during delayed matching tasks. Here we show that LIP inactivation impaired monkeys' task performance during both memory-based discrimination and categorization tasks. These results demonstrate that LIP plays a generalized role in visual categorical decisions independent of the task-structure and motor response modality.
Pengaruh Penambahan Enhancer Isopropil Miristat dan dan Propilen Glikol terhadap Penetrasi Krim Asiklovir
Authors: Dhilasari Estu Mahanani 
Published: May 2023

Acyclovir, a BCS class III drug, has a high ability to fight the herpes virus but has low permeability and is poorly soluble in water. In order to obtain the expected effect of viral infection on the skin, the penetration of the active ingredients becomes a critical factor for a topical treatment to achieve the desired concentration. This study was to see the effect of adding isopropyl myristate and propylene glycol as enhancers that help diffuse the drug through the stratum corneum. The formulation is made by adding enhancer propylene glycol 8% (F1), isopropyl myristate 8% (F2), and without enhancers (F3). Physical stability of acyclovir cream, including homogeneity, organoleptic, pH, viscosity, type of emulsion and power spread, and in vitro cream penetration test with Franz diffusion cells will be observed. The result of acyclovir cream preparations F1, F2, and F3 had a homogeneous preparation of white semisolid and odorless with pH between 7,30-7,60, emulsion type o/w, and a viscosity between 35000-47000 cPS. The cumulative amount of acyclovir penetrated at F3 was 226,008± 8,462 μg/cm2, while the cream containing the enhancers F1 258,059±1,730 μg/cm2 and F2 268,336±0,740 μg/cm2, respectively. The presence of enhancers will increase the penetration ability of acyclovir cream, with more penetration using isopropyl myristate than propylene glycol.
Challenges to Developing and Implementing Policies for Adolescent Online Portal Access
Authors: Sisk Bryan A. , Antes Alison L. , Bereitschaft Christine , Enloe Madi , Bourgeois Fabienne , DuBois James 
Published: May 2023

BACKGROUND
After enactment of the 21st Century Cures Act, many health care systems offer adolescents and parents access to electronic health information through online portals. Few studies have evaluated adolescent portal access policies since the implementation of the Cures Act.

METHODS
We performed structured interviews with informatics administrators in US hospitals with ≥50 dedicated pediatric beds. We performed thematic analysis of challenges to developing and implementing adolescent portal policies.

RESULTS
We interviewed 65 informatics leaders representing 63 pediatric hospitals, 58 health care systems, 29 states, and 14 379 pediatric hospital beds. Most hospitals provided portal access to adolescents (86%) and parents (95%). Filtering of results sent to parental portals ranged widely, with 14% providing unfiltered access, 31% performing minimal filtering for sensitive information, and 43% offering limited access. Portal access policies also varied widely within states. Challenges to developing policies included legislation and compliance issues, tension between confidentiality and usefulness, clinicians’ preferences and concerns, limited understanding and investment of institutions in pediatric issues, and limited focus of vendors on pediatric issues. Challenges to implementing policies included technical challenges, educating end-users, potential for parental coercion, harms of bad news, complex enrollment processes, and informatics workforce limitations.

CONCLUSIONS
Adolescent portal access policies vary widely across and within states. Informatics administrators identified multiple challenges related to developing and implementing adolescent portal policies. Future efforts should strive to develop intrastate consensus on portal policies and to engage parents and adolescent patients to better understand preferences and needs.