bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploiting individual differences to assess the role of place and phase locking cues in frequency discrimination
Authors: Vinay Vinay , Moore Brian C. J. 
Published: June 2023

Abstract
The relative role of place and temporal mechanisms in auditory frequency discrimination was assessed for a centre frequency of 2 kHz. Four measures of frequency discrimination were obtained for 63 normal-hearing participants: detection of frequency modulation using modulation rates of 2 Hz (FM2) and 20 Hz (FM20); detection of a change in frequency across successive pure tones (difference limen for frequency, DLF); and detection of changes in the temporal fine structure of bandpass filtered complex tones centred at 2 kHz (TFS). Previous work has suggested that: FM2 depends on the use of both temporal and place cues; FM20 depends primarily on the use of place cues because the temporal mechanism cannot track rapid changes in frequency; DLF depends primarily on temporal cues; TFS depends exclusively on temporal cues. This led to the following predicted patterns of the correlations of scores across participants: DLF and TFS should be highly correlated; FM2 should be correlated with DLF and TFS; FM20 should not be correlated with DLF or TFS. The results were broadly consistent with these predictions, supporting the idea that frequency discrimination at 2 kHz depends partly or primarily on temporal cues except for frequency modulation detection at a high rate.
Superconductivity in high-entropy alloy system containing Th
Authors: Sobota Piotr , Idczak Rafał , Topolnicki Rafał , Ossowski Tomasz , Pikula Tomasz , Gnida Daniel , Pikul Adam 
Published: June 2023

Abstract
Th-containing superconducting high entropy system with the nomi-nal composition (NbTa)0.67(MoWTh)0.33 was synthesized. Its structural and physical properties were investigated by X-ray diffraction, scanning electron microscopy, energy dispersive X-ray spectroscopy, specific heat, resistivity and magnetic measurements.Two main phases of alloy were observed: major bcc structure and minor fcc. The experimental results were supportedby numerical simulation by the DFT Korringa-Kohn-Rostokermethod with the coherent potential approximation (KKR-CPA).
Graph-Based Strategies for Optimizing Wildfire Suppression
Authors: Aveiro João , Neves Daniel , Silva Paulo , Oliveira Orlando , Nogueira Fernando , Silva Jaime Oliveira da 
Published: June 2023

Abstract
An algorithm for wildfire suppression based on graph theory and that builds on realistic simulations of the propagation, is efficient, produces results in a short period of time and has the potential to help achieving a faster suppression of a real fire is reported.The suppression algorithm looks for the selection of the best locations to attack the suppression of wildfires, is formally correct and its complexity is computed. The performance of the graph-based algorithm is compared to a random and a brute-force approach. The simulations demonstrate that the graph-based algorithm outperforms the other two and that it delivers excellent results.
Spatio-temporal Changes in Hurricane Risk Assessment in the Yucatán Peninsula, Mexico
Authors: Romero David , Léon-Cruz José Francisco 
Published: June 2023

Abstract
Tropical cyclones are considered one of the most dangerous natural hazards. A wide variety of hazards are associated with these natural phenomena, such as strong winds, extreme precipitation, storm surge, flooding, and landslides. In Mexico, tropical cyclones are the most frequent natural threats and have a high cost for the affected populations. This research aims to characterise the temporal change in the risk of hurricanes in the Yucatán Peninsula by analysing its three components (danger, vulnerability, and exposure) for three periods (1945–2000, until 2010, and until 2020). Danger was estimated by calculating the probabilities of occurrence of winds related to hurricane categories using a hexagonal grid from IBTrACS for the period 1945–2021 and NCEI wind fields since 2008. Vulnerability was approximated from the construction of indicators with sociodemographic data from the 2020 National Population and Housing Census issued by Mexico’s National Institute of Statistics and Geography. With these indicators, a factor analysis was carried out and a weighted index was constructed. Finally, exposure was determined from population density. Each of these indices was aggregated at the hexagonal level, allowing the computation of the risk associated with hurricanes. The results show high-risk levels for high danger levels, e.g., axis., on coastal areas such as the Riviera Maya. Likewise, high risk levels are related to marginalisation, i.e., vulnerability, in the north-eastern zone of the Yucatán Peninsula. The increase in the frequency of tropical cyclones combined with high population densities leads to higher risk levels of tropical cyclones.
Study on Collaborative Preparation of Cement Stabilized Materials with "Ternary Solid Wastes" and Their Performance under Dual Excitation Effects
Authors: Zhang Honggang , Ming Yang , 程 春 , Liu Qi , Huang Hui 
Published: June 2023

Abstract
The research of traditional industrial waste in roads is limited to a single waste. To facilitate the application of various industrial solid wastes in pavements. In this paper, a pavement base mixture was prepared collaboratively with "the ternary solid wastes" that formed by steel slag, red mud and electrolytic manganese residues (EMRs) under dual excitation effects, namely alkali and sulfate excitation. Subsequently, a relevant heavy metal curing agent was developed. Afterwards, the physical and mechanical properties of the base mixture were analyzed through (a) 7 d and 28 d unconfined compressive strength tests; (b) 28 d and 90 d splitting and flexural tensile strength tests ; (c)and shrinkage and frost resistance tests. Moreover, the strength formation mechanism of the mixture was explored by combining the X-ray diffraction (XRD) and scanning electron microscopy (SEM) analyses. In addition, the leaching toxicity of the heavy metals was analyzed by detecting their leaching content. It was revealed that (1) the mixture strength was optimal at the mixing proportion of 3:1:2 (steel slag : red mud : EMRs). (2) The mixture strength was improved owing to the calcium silicate hydrate (C-S-H) and ettringite (AFt) crystals generated from the hydration re-action of the "ternary solid wastes" mixture under dual excitation effects. (3) The heavy metal elements in the mixture could be solidified and leached out just by adding 1% of the heavy metal curing agent composed of Cr (hexavalent), Hg, and V elements, thus, meeting sewage discharge standard.
Repeated Mild Traumatic Brain Injury Causes Sex-specific Increases in Cell Proliferation and Inflammation in Juvenile Rats
Authors: Neale Katie J. , Reid Hannah M.O. , Sousa Barbara , McDonagh Erin , Morrison Jamie , Shultz Sandy , Eyolfson Eric , Christie Brian R. 
Published: June 2023

Abstract
Childhood represents a period of significant growth and maturation for the brain, and is also associated with a heightened risk for mild traumatic brain injuries (mTBI). There is also concern that repeated-mTBI (r-mTBI) may have a long-term impact on developmental trajectories. Using an awake closed head injury (ACHI) model, that uses rapid head acceleration to induce a mTBI, we investigated the acute effects of repeated mTBI (r-mTBI) on neurological function and cellular proliferation in juvenile male and female Long Evans rats. We found that r-mTBI did not lead to cumulative neurological deficits with the model. R-mTBI animals exhibited an increase in BrdU+ (bromodeoxyuridine positive) cells in the dentate gyrus (DG), and that this increase was more robust in male animals. This increase was not sustained, and cell proliferation returning to normal by PID3. A greater increase in BrdU+ cells was observed in the dorsal DG in both male and female r-mTBI animals at PID1. Using Ki-67 expression as an endogenous marker of cellular proliferation, a robust proliferative response following r-mTBI was observed in male animals at PID1 that persisted until PID3, and was not constrained to the DG alone. Triple labeling experiments (Iba1+, GFAP+, Brdu+) revealed that a high proportion of these proliferating cells were microglia/macrophages, indicating there was a heightened inflammatory response. Overall, these findings suggest that rapid head acceleration with the ACHI model produces an mTBI, but that the acute neurological deficits do not increase in severity with repeated administration. R-mTBI transiently increases cellular proliferation in the hippocampus, particularly in male animals, and the pattern of cell proliferation suggests that this represents a neuroinflammatory response that is focused around the mid-brain rather than peripheral cortical regions. These results add to growing literature indicating sex differences in proliferative and inflammatory responses between females and males. Targeting proliferation as a therapeutic avenue may help reduce the short term impact of r-mTBI, but there may be sex-specific considerations.
Effect on patellar tracking after total knee arthroplasty with kinematic alignment via the mini-subvastus approach
Authors: sunbochen 孙伯辰 , Xu Yiyang , Chen Long , Luo Fenqi , Lin Yuan , Yu Guoyu , Wang Guiguan , Xu Jie 
Published: June 2023

Abstract
Background The differences in prosthetic positioning resulting from total knee arthroplasty (TKA) employing different alignment strategies (kinematic alignment [KA] versus mechanical alignment [MA]) lead to differences in patellar tracking. This study aimed to analyze the effect of imaging-related attributes and clinical efficacy of patellar tracking after TKA with KA via the mini-subvastus approach.Methods This prospective randomized controlled study involved 100 patients who were randomly and equally divided into the KA and MA groups prior to undergoing the TKA surgical procedure. The preoperative and postoperative patellar tilt angle, lateral patellar shift, Knee Society Score (KSS), and Oxford Knee Score (OKS) were compared between patients of the KA and MA groups. In addition, the intraoperative lateral patellar retinaculum release rate was also compared between these two patient groups.Results All patients were followed up for 6 months post-TKA. There was no significant difference in the demographics and preoperative and postoperative imaging-related attributes of the patellar tracking between the two groups (p > 0.05). The postoperative KSS and OKS of the KA group were significantly higher than those of the MA group (p < 0.05). The release rate of the lateral retinaculum of the patella was 6.00% (3/50) in the KA group and 28.00% (14/50) in the MA group, and the difference was statistically significant (x2 = 8.575, p < 0.05).Conclusion Good patellar tracking was achieved in both groups after TKA via the mini-subvastus approach. Nevertheless, the KA strategy was associated with a lower rate of intraoperative lateral patellar retinaculum release and higher knee function scores and therefore, may be considered the superior strategy for TKA.
Transfection of Hypoxia-Inducible Factor-1α mRNA Upregulates the Expression of Genes Encoding Angiogenic Growth Factors
Authors: Wlodarczyk Jakub , Leng Albert , Abadchi Sanaz Nourmohammadi , Shababi Niloufar , Mokhtari-Esbuie Farzad , Gheshlaghi Shayan , Ravari Mohsen Rouhani , Pippenger Emma , Afrasiabi Ali , Ha Jinny , Abraham John , Harmon John 
Published: June 2023

Abstract
Hypoxia-Inducible Factor-1α (HIF-1α) has presented a new direction for ischemic preconditioning of surgical flaps to promote their survival. In a previous study, we demonstrated the effectiveness of HIF-1a DNA plasmids in this application. In this study, to avoid complications associated with plasmid use, we sought to express HIF-1α through mRNA transfection and determine its biological activity by measuring the upregulation of downstream angiogenic genes. We transfected six different HIF-1a mRNAs–one predominant, three variant, and two novel mutant isoforms–into primary human dermal fibroblasts using Lipofectamine, and assessed mRNA levels using RT-qPCR. At all time points examined after transfection (3, 6, and 10 hours), the levels of HIF-1α transcript were significantly higher in all HIF-1α transfected cells relative to the control (all p < 0.05, unpaired Student’s T-test). Importantly, the expression of HIF-1α transcription response genes (VEGF, ANG-1, PGF, FLT1, and EDN1) was significantly higher in the cells transfected with all isoforms than with the control at six and/or ten hours post-transfection. All isoforms were transfected successfully into human fibroblast cells, resulting in the rapid upregulation of all five downstream angiogenic targets tested. These findings support the potential use of HIF-1α mRNA for protecting ischemic dermal flaps.
Ambulatory Blood Pressure Monitoring in Children and Adolescents Post-Hematopoietic Stem Cell Transplantation
Authors: Homhuan Warinpapha , Tosakulsak Thitirat , Pirojsakul Kwanchai , Pakakasama Samart , Satawiriya Marin , Paksi Witchuri , Bunmee Uthen 
Published: June 2023

Abstract
Background: One of the long-term complications after hematopoietic stem cell transplantation (HSCT) is hypertension (HT). Previous studies showed that 10-15% of children post-HSCT had office HT but a few studies used ambulatory blood pressure monitoring (ABPM). The present study aimed to determine the frequency and explore the factors associated with ABPM HT in children post-HSCT.
Methods: Patients aged ≥ 6 years who survived ≥ 2 years after HSCT were enrolled. ABPM and echocardiographic results were reviewed. ABPM HT was defined according to the 2022 American Heart Association guidelines. The blood pressure (BP) index was calculated as BP value divided by HT cut-off value for each patient. Factors associated with HT were analyzed by logistic regression.
Results: Ninety-nine (61 males) patients with a mean age of 14.6 years were included. Sixteen patients (16.1%) had ABPM HT (2 ambulatory HT and 14 masked HT). The ABPM HT group had a higher age (18.8 vs 14.4 years, p < 0.01), a higher proportion of males (87.5% vs 56.6%, p = 0.02), a higher office systolic BP index (0.93 vs 0.85, p < 0.01), a higher office diastolic BP index (0.96 vs 0.83, p < 0.01), a higher proportion of current use of prednisolone and tacrolimus than those in the normal ABPM group. Multivariate analysis revealed that office diastolic BP index was associated with ABPM HT. Left ventricular mass index had a significant positive correlation with ABPM but not with office BP parameters.
Conclusion: HT in children post-HSCT was not uncommon and most could not be detected with office BP measurement. A diastolic BP index can be used as a screening tool to refer these patients for ABPM.
Evaluating the Role of Neoadjuvant and Adjuvant Chemotherapy in Gastric Cancer: A Retrospective Study and Future Directions
Authors: Sah Birendra Kumar , Yu Zhen jia , Lu Sheng , Zheng Yanan , Zhu Zhenglun , Li Jian , Li Chen , Yan Min , Zhu Zhenggang 
Published: June 2023

Abstract
Background
Different types of neoadjuvant chemotherapy regimens have been compared for gastric cancer, mostly in terms of radiological downgrading or pathological tumor regression; however, no large-scale multicenter randomized controlled trial (RCT) has conducted a head-to-head comparison of the overall survival rate between perioperative or neoadjuvant chemotherapy(NAC) and postoperative or adjuvant chemotherapy(AC). We explored whether the five-year overall survival rate was greater in patients who received perioperative chemotherapy plus surgery than in those who underwent surgery first and then underwent postoperative chemotherapy.
Methods
Altogether, 77 patients with a clinical diagnosis of cTNM stage III were included. Five-year overall survival (OS) rates were compared between patients who underwent neoadjuvant chemotherapy plus surgery (NAC) and those who underwent surgery first plus adjuvant chemotherapy (AC). Propensity score matching was used to adjust for disparity between the two groups. A Kaplan-Meier plot was created for survival analysis, and the log-rank method was used to compare the differences in OS.
Results
A total of 34 patients were in the NAC and 43 patients were in the AC group, respectively. There was no significant difference in age (median, 64 vs. 66 years), cTNM staging, or extent of gastrectomy between the two groups (p < 0.05). The median follow-up time was 58 months (range: 53–65 months). The five-year overall survival (OS) rates for patients in the NAC and AC groups were 61.8% and 73.5%, respectively. There was no significant difference between the two groups in the five-year overall survival rates (p > 0.05). There was no significant difference in the severity of postoperative complications between the two groups (p > 0.05).
Conclusions
There was no significant difference in the five-year overall survival rate between patients who underwent perioperative chemotherapy plus surgery and those who underwent surgery plus postoperative chemotherapy alone. A well-controlled prospective study is necessary to confirm whether perioperative chemotherapy is superior to postoperative chemotherapy in patients with GC.
Single-cell sequencing reveals the reproductive variations between primiparous and multiparous Hu ewes
Authors: Ge Ting , Wen Yifan , Li Bo , Huang Xiaoyu , Jiang Shaohua , Zhang Enping 
Published: June 2023

Abstract
In the modern sheep production systems, the reproductive performance of ewes determines the economic profitability of farming. Revealing the genetic mechanisms underlying differences in the litter size is important for the selection and breeding of highly prolific ewes. Hu sheep is a high-quality Chinese sheep breed with high fecundity and it is an ideal model for investigating prolificacy traits. In the current study, animals were divided into two groups according to their delivery rates in three consecutive lambing seasons (namely, the High-reproduction and lowly reproductive groups with ≥ 3 lambs and one lamb per season, respectively). Three ewes were randomly picked from each group and slaughtered within 12 h of estrus, and unilateral ovarian tissues were collected and analyzed by single-cell RNA sequencing. A total of five types of somatic cells were identified and corresponding expression profiles were mapped in the ovaries of each group. Noticeably, the differences in the ovary somatic cell expression profiles between the High-reproduction and lowly reproductivegroups were mainly clustered in the granulosa cells, a cell line that is significantly relevant to female prolificacy. In addition, four granulosa cell subtypes were identified. GeneSwitches revealed that the abundance of the JPH1 expression and the reduction of the LOC101112291 expression could lead to different evolutionary directions of the granulosa cells. The expression levels of FTH1 and FTL in GCs of the Highly reproductive group were significantly higher, which inhibited necroptosis and ferroptosis of mural GCs from decreasing follicular atresia. This study constructed the gene expression atlas of the sheep ovary and revealed related biological characteristics at the cellular and molecular levels. It also provides a theoretical basis for the mechanisms underlying the differences in ovulation numbers, which will be helpful for breeding and molecular genetics-based selection of highly prolific ewes.
Unraveling Childhood Vaccination Hesitancy: A Thematic Analysis of the Perceptions of Highly Educated Mothers in Kazakhstan
Authors: Abdirakhman Togzhan , Balay-odao Ejercito Mangawa , Aljofan Mohamad , Cruz Jonas Preposi 
Published: June 2023

Abstract
Background
Vaccine hesitancy among parents directly affects the child's vaccination status, since they are the legal decision-makers regarding vaccinating their children. The study aimed to describe the perceptions of Kazakhstani mothers about routine childhood vaccination.
Methods
The study utilized a descriptive phenomenological study to describe mothers' perceptions of childhood vaccination in Kazakhstan. A purposive sample of 95 participants comprehensively answered the free-text questions in an online self-administered questionnaire from January to February 2023. The analysis of the free-text responses followed a thematic analysis approach.
Results
The in-depth analysis of the data, 285 initial codes were extracted. The combination of similar meanings and concept codes leads to 19 categories and finally arriving at four significant themes: misconceptions about childhood vaccination, fear of the vaccine's effect on children, distrust of the health care system, and social learning factors.
Conclusions
The themes related to the perceptions of Kazakh mother mothers about childhood vaccination may lead to behaviors of delaying and refusing some or all childhood vaccines. Therefore, motivational and educational strategies can be used by healthcare providers to instill trust in parents about childhood vaccines and their safety and effectiveness.
Development Of A Kiln Petcoke Mill Predictive Model Based On A Multi-Regression Xgboost Algorithm
Authors: BENCHEKROUN MOHAMMED TOUM , ZAKI Smail , ABOUSSALEH Mohamed , BELRHITI Hajar , DIASSANA Fatoumata 
Published: June 2023

Abstract
This paper presents an investigation into the optimization of Petroleum Coke Mill or Petcoke mill processes, with the goal of improving efficiency and reducing waste in the heavy industry within the cement plant where our study is conducted. Our mission was to create a robust algorithm that can properly anticipate the mill’s performance and improve its operations. To accomplish this, we started by performing a comprehensive data analysis. Next, we built numerous regression models, then assessed the effectiveness of each model using four crucial metrics. The suggested model is a multi-regression XGBoost (eXtreme Gradient Boosting) model, performing with a 90% score. Finally, the model will then be used to build an algorithm that can optimize the input values to accomplish the intended results.
Agrivoltaic Insect Net House: Clean &amp; Sustainable Energy generation Technology with zero carbon emission
Authors: Gadhiya G. A. , Patel U. R. , Chauhan P. M. 
Published: June 2023

Abstract
Food and energy are now the most important resources for any country. Different land areas are used to cultivate these two resources. To accomplish both task simultaneously on the same piece of land, Agrivoltaic systems were developed. Keep in mind that Agrivoltaic systems have no control over their microclimates as we can control in green house, Agrivoltaic systems are inappropriate for vegetable crops, which require intense insect and pest management. But marginal farmers cannot afford greenhouse due to the high cost of maintenance. Controlling pests and pathogens in vegetable crops is made possible by the development of insect net houses that are affordable for small farmers to maintain. Therefore, we create a more advanced insect net houses that can be used as both an insect net house and Agrivoltaic system. The Agrivoltaic insect net house completely replaces the concept of insect net houses while being economically viable for farmers. The Agrivoltaic structure having 1.8 kW capacity is positioned at a height of 3 metres to provide easy tractor movement beneath it for various farming tasks. The Yst310 grade CRC square pipes used in the construction which can withstand wind speeds of up to 140.4 km/hr. The Agrivoltaic Insect Net House has an overall cost of Rs. 88474, which is more affordable for farmers than greenhouse. A total of 2492.83 kWh (75.62 kWh/m2) of electricity is produced which reduces 28.05 kg/m2 carbon emission over the course of the year, with benefit-cost ratio of 1.18.