bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transition Metal‐Free Aromatic C−H, C−N, C−S and C−O Borylation
Authors: Luo Lu , Tang Shuai , Wu Jiangyue , Jin Shiwei , Zhang Hua 
Published: February 2023

AbstractAromatic organoboron compounds are highly valuable building blocks in organic chemistry. They were mainly synthesized through aromatic C−H and C−Het borylation, in which transition metal‐catalysis dominate. In the past decade, with increasing attention to sustainable chemistry, numerous transition metal‐free C−H and C−Het borylation transformations have been developed and emerged as efficient methods towards the synthesis of aromatic organoboron compounds. This account mainly focuses on recent advances in transition metal‐free aromatic C−H, C−N, C−S, and C−O borylation transformations and provides insights to where further developments are required.
Genome‐wide association mapping for pre‐harvest sprouting in European winter wheat detects novel resistance QTL, pleiotropic effects, and structural variation in multiple genomes
Authors: Dallinger Hermann G. , Löschenberger Franziska , Azrak Naim , Ametz Christian , Michel Sebastian , Bürstmayr Hermann 
Published: February 2023

AbstractPre‐harvest sprouting (PHS), germination of seeds before harvest, is a major problem in global wheat (Triticum aestivum L.) production, and leads to reduced bread‐making quality in affected grain. Breeding for PHS resistance can prevent losses under adverse conditions. Selecting resistant lines in years lacking pre‐harvest rain, requires challenging of plants in the field or in the laboratory or using genetic markers. Despite the availability of a wheat reference and pan‐genome, linking markers, genes, allelic, and structural variation, a complete understanding of the mechanisms underlying various sources of PHS resistance is still lacking. Therefore, we challenged a population of European wheat varieties and breeding lines with PHS conditions and phenotyped them for PHS traits, grain quality, phenological and agronomic traits to conduct genome‐wide association mapping. Furthermore, we compared these marker‐trait associations to previously reported PHS loci and evaluated their usefulness for breeding. We found markers associated with PHS on all chromosomes, with strong evidence for novel quantitative trait locus/loci (QTL) on chromosome 1A and 5B. The QTL on chromosome 1A lacks pleiotropic effect, for the QTL on 5B we detected pleiotropic effects on phenology and grain quality. Multiple peaks on chromosome 4A co‐located with the major resistance locus Phs‐A1, for which two causal genes, TaPM19 and TaMKK3, have been proposed. Mapping markers and genes to the pan‐genome and chromosomal alignments provide evidence for structural variation around this major PHS‐resistance locus. Although PHS is controlled by many loci distributed across the wheat genome, Phs‐A1 on chromosome 4A seems to be the most effective and widely deployed source of resistance, in European wheat varieties.
Seed Processing for Quality Upgradation
Authors: Sinha J. P. , Kumar Ashwani , Weissmann Elmar 
Published: February 2023

AbstractPre-harvest and post-harvest operations are integral parts of the quality seed production system. If due attention is not paid during the first phase, probably therewill not be any means left to obtain quality seed. Similarly, good quality seed produced with utmost care may lose much of its value if proper management is not followed during the post-harvest period. The seed quality attributes are genetic purity, appearance and physical purity, germination potential, vigour and seed health. Proper attention should be given during both the phases of seed production, regarding all the attributes of seed quality. Genetic purity is primarily linked with production or pre-harvest phase. Whereas, physical purity is primarily achieved in post-harvest phase. The harvested raw seed mass consists of various materials other than seed (MOS). MOS may be trash, plant parts, inert matter, weeds, other crop seeds and non-viable seeds, e.g. cut grains, insect pest damaged, off sized or physically damaged kernels, etc. Such contaminants reduce seed quality and increase the volume of harvested seed mass that requires additional space during storage. Moreover, these contaminants often attract pest infestation, which can further cause seed loss both in terms of quality and quantity. Proper storage of processed and clean seed is also an essential component of seed programmes as the sowing season normally falls at least six to nine months after the production season.
Emerging Trends and Promising Technologies
Authors: Dadlani Malavika 
Published: February 2023

AbstractThe growing demands for improved seeds of food, vegetables, flowers, other horticultural species, feed, fibre, forage, and fuel crops are driving the global seed industry at a CAGR of 6.6%, which is expected to grow from a market size of USD 63 billion in 2021 to USD 86.8 billion by 2026. This will primarily depend on two key features, genetic enhancement of the crop variety and seed quality. The focus of varietal improvement will be not only on yield increase but also on tolerance against biotic and abiotic stresses to meet the challenges of climate change, better input use efficiency, and improvement of the nutritional value. Advanced molecular tools and techniques including gene editing are likely to be used for precision breeding. The scope of seed quality, on the other hand, will grow beyond the basic parameters of purity, germination, and health, to the ability to perform better under adverse growing conditions, supplement the nutrient deficiency in the soil, and withstand pests during seed germination and early growth stages. Seed enhancement technologies will complement the genetic enhancement, as the advancements in seed technology will become an integral part of future crop improvement programmes. This will call for more efficient and precise technologies for determining quality parameters and predicting seed longevity, which will need to be developed using advanced marker technologies, 3D and multispectral imaging analysis, digital phenotyping, and other non-destructive methods. Novel approaches of hybrid seed production, including apomixis and doubled haploidy, will be integrated further for their commercial application. Multi-dimensional approaches need to be taken for addressing the gaps in understanding the key physiological processes underlying the regulation of dormancy (and pre-harvest sprouting), germination, recalcitrance, loss of viability, and seed priming.
Behavioural effects of APH199, a selective dopamine D4 receptor agonist, in animal models
Authors: Chestnykh Daria , Graßl Fabian , Pfeifer Canice , Dülk Jonas , Ebner Chiara , Walters Mona , von Hörsten Stephan , Kornhuber Johannes , Kalinichenko Liubov S. , Heinrich Markus , Müller Christian P. 
Published: February 2023

Abstract
Rationale
The dopamine D4 receptors (DRD4) play a key role in numerous brain functions and are involved in the pathogenesis of various psychiatric disorders. DRD4 ligands have been shown to moderate anxiety, reward and depression-like behaviours, and cognitive impairments. Despite a series of promising but ambiguous findings, the therapeutic advantages of DRD4 stimulation remain elusive.

Objectives
The investigation focused on the behavioural effects of the recently developed DRD4 agonist, APH199, to evaluate its impact on anxiety, anhedonia, behavioural despair, establishment and retrieval of alcohol reinforcement, and amphetamine (AMPH)-induced symptoms.

Methods
Male C57BL/6 J mice and Sprague–Dawley rats were examined in five independent experiments. We assessed APH199 (0.1–5 mg/kg, i.p.) effects on a broad range of behavioural parameters in the open field (OF) test, conditioned place preference test (CPP), elevated plus maze (EPM), light–dark box (LDB), novelty suppressed feeding (NSF), forced swim test (FST), sucrose preference test (SPT), AMPH-induced hyperlocomotion test (AIH), and prepulse inhibition (PPI) of the acoustic startle response in AMPH-sensitized rats.

Results
APH199 caused mild and sporadic anxiolytic and antidepressant effects in EPM and FST, but no remarkable impact on behaviour in other tests in mice. However, we found a significant increase in AMPH-induced hyperactivity, suggesting an exaggeration of the psychotic-like responses in the AMPH-sensitized rats.

Conclusions
Our data challenged the hypothesis of the therapeutic benefits of DRD4 agonists, pointing out a possible aggravation of psychosis. We suggest a need for further preclinical studies to ensure the safety of antipsychotics with DRD4 stimulating properties.
Determination of polyurethanes within microplastics in complex environmental samples by analytical pyrolysis
Authors: Coralli Irene , Goßmann Isabel , Fabbri Daniele , Scholz-Böttcher Barbara M. 
Published: February 2023

AbstractPolyurethanes (PUR) are a group of polymers synthesized from different diisocyanate and polyol monomers resulting in a countless number of possible structures. However, the large market demand, and the variety of application fields justify the inclusion of PUR in microplastic (MP) investigation. This study aimed at providing comprehensive information on PUR within MP analysis by pyrolysis–gas chromatography-mass spectrometry to clarify whether (i) it is possible to make a reliable statement on the PUR content of environmental samples based on a few pyrolysis products and (ii) which restrictions are required in this context. PUR were managed as subclasses defined by the diisocyanates employed for polymer synthesis. Methylene diphenyl diisocyanate (MDI)- and toluene diisocyanate (TDI)-based PUR were selected as subclasses of greatest relevance. Different PUR were pyrolyzed directly and under thermochemolytic conditions with tetramethylammonium hydroxide (TMAH). Distinct pyrolytic indicators were identified. The study supported that the use of TMAH greatly reduced the interactions of pyrolytic MP analytes with the remaining organic matrix of environmental samples and the associated negative effects on analytical results. Improvements of chromatographic behavior of PUR was evidenced. Regressions (1–20 µg) showed good correlations and parallelism tests underlined that quantitation behavior of different MDI-PUR could be represented by the calibration of just one representative with sufficient accuracy, entailing a good estimation of the entire subclass if thermochemolysis were used. The method was exemplary applied to road dusts and spider webs sampled around a plastic processing plant to evaluate the environmental spread of PUR in an urban context. The environmental occurrence of MDI-PUR as MP was highly influenced by the proximity to a potential source, while TDI markers were not observed.
Graphical Abstract
Analysis of local head losses in microirrigation lateral connectors based on machine learning approaches
Authors: Martí Pau , Shiri Jalal , Román Armand , Turégano José Vicente , Royuela Álvaro 
Published: February 2023

AbstractThe presence of emitters along the lateral, as well as of connectors along the manifold, causes additional local head losses other than friction losses. An accurate estimation of local losses is of crucial importance for a correct design of microirrigation systems. This paper presents a procedure to assess local head losses caused by 6 lateral start connectors of 32- and 40-mm nominal diameter each under actual hydraulic working conditions based on artificial neural networks (ANN) and gene expression programming (GEP) modelling approaches. Different input–output combinations and data partitions were assessed to analyse the hydraulic performance of the system and the optimum training strategy of the models, respectively. The range of the head losses in the manifold (hsM) is considerable lower than in the lateral (hsL). hsMincreases with the protrusion ratio (s/S). hsLdoes not decrease for a decreasing s/S. There is a correlation between hsLand the Reynolds number in the lateral (ReL). However, this correlation might also be dependent on the flow conditions in the manifold before the derivation. The value of the head loss component due to the protrusion might be influenced by the flow derivation. DN32 connectors and hsMpresent more accurate estimates. Crucial input parameters are flow velocity and protrusion ratio. The inclusion of friction head loss as input also improves the estimating accuracy of the models. The range of the indicators is considerably worse for DN40 than for DN32. The models trained with all patterns lead to more accurate estimations in connectors 7 to 12 than the models trained exclusively with DN40 patterns. On the other hand, including DN40 patterns in the training process did not involve any improvement for estimating the head losses of DN32 connectors. ANN were more accurate than GEP in DN32. In DN40 ANN were less accurate than GEP for hsM, but they were more accurate than GEP for hsL, while both presented a similar performance for hscombined. Different equations were obtained using GEP to easily estimate the two components of the local loss. The equation that should be used in practice depends on the availability of inputs.
Labile carbon inputs support the recovery of bacterial communities, but not fungal communities, from a simulated bovine urine event
Authors: Dopheide Andrew , Davis Carina , Wakelin Steve A. , Whitehead David , Grelet Gwen-Aëlle 
Published: February 2023

AbstractInputs of carbon to soil may be used to stimulate microbial growth and immobilize excess nitrogen from sources such as livestock urine. However, the growth responses of microbial taxa to carbon inputs under conditions of excess soil nitrogen remain poorly understood. Using DNA metabarcoding and a field-based soil lysimeter experiment, we characterised the temporal responses (up to 112 days) of bacterial and fungal communities to a simulated bovine urine event plus inputs of labile carbon (sucrose) at two concentrations. Fungal communities were impacted more strongly than bacterial communities by carbon inputs following the simulated urine event, with more variable responses among taxa. Chytridiomycota and Glomeromycota richness were most negatively affected, and Tremellomycetes richness most positively affected, by carbon inputs. A minority of fungal ASVs had greatly increased proportional abundances in response to carbon, while fungal trophic composition became highly dominated by saprotrophs by the experiment end. Bacterial taxa showed consistent trends of declining (to about 14 days) and recovering (to 112 days) richness in response to urine and carbon inputs, but carbon-related evenness and proportional abundance trends varied between taxa. Proportional abundances of Actinobacteria, Bacteroidetes, Betaproteobacteria, and Gammaproteobacteria increased in response to carbon, whereas proportional abundances of Acidobacteria, candidate division WPS-1, Planctomycetes, Deltaproteobacteria, and Verrucomicrobia decreased. These results show that labile carbon inputs to limit nitrate leaching support the recovery of bacterial communities to bovine urine events but may have long-term impacts on fungal community composition and function, with potential consequences for soil food webs, carbon sequestration, and agricultural productivity.
Masculine depression and its problem behaviors: use alcohol and drugs, work hard, and avoid psychiatry!
Authors: von Zimmermann Claudia , Hübner Magdalena , Mühle Christiane , Müller Christian P. , Weinland Christian , Kornhuber Johannes , Lenz Bernd 
Published: February 2023

AbstractThe gender role influences vulnerability to mental illness. Substance use, even critical in scale, is perceived as masculine, just like hard (over-)work, while not seeking help. With the ongoing separation between gender and sex, masculine norms become more relevant also to females’ mental health. The male depression concept highlights the role of male symptoms in affective disorders. However, the empirical evidence is still limited. Here, we use the denomination ‘masculine depression’ to open the category for female patients and tested substance use patterns, health services’ utilization, and working hours as predictors in a case–control study of 163 depressed in-patients (44% women; masculine vs. non-masculine depression according to a median split of the Male Depression Rating Scale-22) and 176 controls (51% women). We assessed higher depression severity in patients with masculine (vs. non-masculine) depression. Masculine depression (vs. non-masculine depression and vs. no depression) was predicted by more frequent and critical use of alcohol (including binge drinking), tobacco, and illicit drugs, and by longer working times. Moreover, fewer health services contacts due to mental complaints during the previous year were associated with masculine (vs. non-masculine) depression. Alarmingly, even critical substance misuse was not significantly associated with more frequent health services contacts; however, the higher the depression severity, the more contacts the patients reported. Here, we provide evidence that patients with masculine depression are highly burdened and undertreated, which applies equally to female and male patients. This study identified promising targets to establish specialized care offers.
Risk of new onset and persistent psychopathology in children with long-term physical health conditions: a population-based cohort study
Authors: Panagi Laura , White Simon R. , Dai Xiaolu , Bennett Sophie , Shafran Roz , Ford Tamsin 
Published: February 2023

AbstractChildren and young people (CYP) with long-term physical health conditions (pLTCs) have increased risk of psychopathology compared to physically healthier peers. We explored risk factors for new onset and persistent psychiatric disorders in CYP with pLTCs compared to CYP without pLTCs. This 3-year follow-up study involved a UK representative sample of CYP from the British Child and Adolescent Mental Health Surveys (N = 7804). We examined potential baseline predictors of new onset and persistent psychiatric disorders at follow-up in four groups of children based on the presence of any physical and/or any psychiatric conditions at baseline. Psychiatric disorders were assessed using standardised multi-informant diagnostic assessment. Separate multivariable binary logistic regressions were conducted for each group. In CYP with pLTCs, rented housing (aOR = 1.42, 95% CI  1.01 to 1.99), non-traditional family structure (aOR = 2.08, 95% CI  1.42 to 3.05), increased parental distress (aOR = 1.09, 95% CI  1.04 to 1.14), and greater peer relationship difficulties (aOR = 1.29, 95% CI  1.19 to 1.39) predicted future psychiatric disorder. Only peer relationship difficulties predicted persistent disorder (aOR = 1.27, 95% CI  1.17 to 1.38) in this group. A greater number of factors predicted the onset of psychiatric disorder in CYP with pLTCs compared to physically healthier peers and similarly, a higher number of factors predicted persistent disorder in CYP without pLTCs. CYP with pLTCs might comprise a group with different vulnerabilities, some of which are potentially tractable and may be useful indicators of patients who require preventable or management interventions.
Confronting climate change and livelihood: smallholder farmers’ perceptions and adaptation strategies in northeastern Burundi
Authors: Batungwanayo Pacifique , Habarugira Viateur , Vanclooster Marnik , Ndimubandi Jean , F. Koropitan Alan , Nkurunziza Jean de Dieu 
Published: February 2023

AbstractRain-fed
agriculture is the main source of livelihood for most of Burundi’s population, especially in the northeastern part of the country. This research is aimed at examining how smallholder farmers in the Northeastern region of Burundi perceive climate change and variability and at identifying the methods that are used to adapt, based on data from 200 small farmers and on actual weather data recorded between 1986 and 2017. We find that the majority of farmers (54%) perceive significant increases in temperature and unpredictability of rainfall duration and intensity and are making adjustments to adapt their agriculture in response to changes in climate. Over 80% of farmers have implemented at least one adaptation strategy among the nine evaluated. Changing crop varieties, changing fertilizers, and planting shade trees are the main adaptation strategies that were being implemented by farmers across the study area. The results of a binary regression model showed that the agricultural education and experience of farmers, as well as farm and family size, livestock ownership, climate information access, credit access, and farm income, strongly influence smallholder farmers’ decisions to adapt to climate change. The main obstacles are the lack of information on climate and adaptation strategies, and poverty, which makes it difficult to cope with the increased costs of farming. Understanding farmers’ perceptions of climate change and variability on a local level would provide information on how to develop adaptation strategies. The present study suggests the need for strengthening farmers’ capacities and improving the policy framework for adaptation to climate change in order to improve farmers’ livelihoods. Implications for policymakers will, therefore, include making flexible credit facilities, and investing in training extension agents on both climate change outreach and coping strategies.
Determinants of churn in telecommunication services: a systematic literature review
Authors: Ribeiro Hugo , Barbosa Belém , Moreira António Carrizo , Rodrigues Ricardo Gouveia 
Published: February 2023

AbstractThe telecommunications industry is particularly competitive and characterized by very high churn rates. The literature on the topic is vast, but studies on the determinants of churn behavior are dispersed, failing to provide a comprehensive view of the state of the art. Based on this research gap, this article aims to contribute to developing the literature on customer churn in the telecommunications sector by summarizing the current state of research, and identifying the main determinants of churn and switching intentions. It provides a systematic literature review (SLR) of 37 articles on the topic published between 1999 and 2022. The results reveal the existence of two research streams. The first, in which the studies are based on surveys examining the alleged intentions of subscribers to change operators, with criteria such as satisfaction and attitudes as predictors, and the second, dealing with subscribers’ actual switching behavior and relating this to behaviors and characteristics extracted from internal customer management systems. All independent variables used to explain switching intention or real churn were mapped. It was found that age, gender, satisfaction, switching costs and barriers, and service quality are the most important determinants highlighted by the literature. Our study also outlines some insightful practical implications, which could be extended to other service sectors. The paper ends with a research agenda for future studies according to the gaps detected by the study’s results. Among its limitations, this research excludes papers related to predictive models and studies not in English.