bluuebunny/crossref_metadata_2025_split huggingface dataset:
Astrocytic LRRK2 Controls Synaptic Connectivity via Regulation of ERM Phosphorylation
Authors: Wang Shiyi , Baumert Ryan , Séjourné Gabrielle , Bindu Dhanesh Sivadasan , Dimond Kylie , Sakers Kristina , Vazquez Leslie , Moore Jessica , Tan Christabel Xin , Takano Tetsuya , Rodriguez Maria Pia , Soderling Scott H. , La Spada Albert R. , Eroglu Cagla 
Published: April 2023

SUMMARYAstrocytes, a major glial cell type of the brain, regulate synapse numbers and function. However, whether astrocyte dysfunction can cause synaptic pathologies in neurological disorders such as Parkinson’s Disease (PD) is unknown. Here, we investigated the impact of the most common PD-linked mutation in the leucine-rich repeat kinase 2 (LRRK2) gene (G2019S) on the synaptic functions of astrocytes. We found that both in human and mouse cortex, the LRRK2 G2019S mutation causes astrocyte morphology deficits and enhances the phosphorylation of the ERM proteins (Ezrin, Radixin, and Moesin), which are important components of perisynaptic astrocyte processes. Reducing ERM phosphorylation in LRRK2 G2019S mouse astrocytes restored astrocyte morphology and corrected excitatory synaptic deficits. Using anin vivoBioID proteomic approach, we found Ezrin, the most abundant astrocytic ERM protein, interacts with the Autophagy-Related 7 (Atg7), a master regulator of catabolic processes. The Ezrin/Atg7 interaction is inhibited by Ezrin phosphorylation, thus diminished in the LRRK2 G2019S astrocytes. Importantly, Atg7 function is required to maintain proper astrocyte morphology. These studies reveal an astrocytic molecular mechanism that could serve as a therapeutic target in PD.
A hybridin silico/in-cell controller for microbial bioprocesses with process-model mismatch
Authors: Ohkubo Tomoki , Soma Yuki , Sakumura Yuichi , Hanai Taizo , Kunida Katsuyuki 
Published: April 2023

AbstractThe optimization of bioprocess inputs using mathematical models is widely practiced. However, the mismatch between model prediction and the actual process [called process-model mismatch (PMM)] is problematic; when a large PMM exists, the process inputs optimized using the mathematical model in advance are no longer optimal for the actual process. In this study, we propose a hybrid control system that combines model-based optimization (in silicofeedforward controller) and feedback controllers using synthetic genetic circuits integrated into cells (in-cell feedback controller) – which we named the hybridin silico/in-cell controller (HISICC) – as a solution to this PMM issue. As a proof of concept for HISICC, we constructed a mathematical model of an engineeredEscherichia colistrain for the isopropanol production process that was previously developed. This strain contains an in-cell feedback controller, and its combination with anin silicocontroller can be regarded as an example of HISICC. We demonstrated the robustness of HISICC against PMM by comparing the strain with another strain with no in-cell feedback controller in simulations assuming PMM of various magnitudes.
GALBA: Genome Annotation with Miniprot and AUGUSTUS
Authors: Brůna Tomáš , Li Heng , Guhlin Joseph , Honsel Daniel , Herbold Steffen , Stanke Mario , Nenasheva Natalia , Ebel Matthis , Gabriel Lars , Hoff Katharina J. 
Published: April 2023

AbstractThe Earth Biogenome Project has rapidly increased the number of available eukaryotic genomes, but most released genomes continue to lack annotation of protein-coding genes. In addition, no transcriptome data is available for some genomes. Various gene annotation tools have been developed but each has its limitations. Here, we introduce GALBA, a fully automated pipeline that utilizes miniprot, a rapid protein- to-genome aligner, in combination with AUGUSTUS to predict genes with high accuracy. Accuracy results indicate that GALBA is particularly strong in the annotation of large vertebrate genomes. We also present use cases in insects, vertebrates, and a previously unannotated land plant. GALBA is fully open source and available as a docker image for easy execution with Singularity in high-performance computing environments. Our pipeline addresses the critical need for accurate gene annotation in newly sequenced genomes, and we believe that GALBA will greatly facilitate genome annotation for diverse organisms.
Does students’ performance in the formative CLIPP examination predict their scores in the NBMEPSE?
Authors: Almekhaini Lolowa , Alsuwaidi Ahmad R. , Alkaabi Khaula Khalfan , Al Hamad Sania , Narchi Hassib 
Published: April 2023

PurposeComputer-Assisted Learning in Pediatrics Program (CLIPP) and National Board of Medical Examiners Pediatric Subject Examination (NBMEPSE) are used to assess students’ performance during pediatric clerkship. International Foundations of Medicine (IFOM) assessment is organized by NBME and taken before graduation. This study explores the ability of CLIPP assessment to predict students’ performance in their NBMEPSE and IFOM examinations.Design/methodology/approachThis cross-sectional study assessed correlation of students’ CLIPP, NBMEPSE and IFOM scores. Students’ perceptions regarding NBMEPSE and CLIPP were collected in a self-administered survey.FindingsOut of the 381 students enrolled, scores of CLIPP, NBME and IFOM examinations did not show any significant difference between genders. Correlation between CLIPP and NBMEPSE scores was positive in both junior (r = 0.72) and senior (r = 0.46) clerkships, with a statistically significant relationship between them in a univariate model. Similarly, there was a statistically significant relationship between CLIPP and IFOM scores. In an adjusted multiple linear regression model that included gender, CLIPP scores were significantly associated with NBME and IFOM scores. Male gender was a significant predictor in this model. Results of survey reflected students’ satisfaction with both NBMEPSE and CLIPP examinations.Originality/valueAlthough students did not perceive a positive relationship between their performances in CLIPP and NBMEPSE examinations, this study demonstrates predictive value of formative CLIPP examination scores for their future performance in both summative NBMEPSE and IFOM. Therefore, students with poor performance in CLIPP are likely to benefit from feedback and remediation in preparation for summative assessments.
Mediating influence of earnings management in the nexus between audit quality and company value: new proof from Jordanian market
Authors: Abu Afifa Malik Muneer , Saleh Isam , Taqatqah Fatima 
Published: April 2023

Purpose
This paper aims to recognize the direct influence of audit quality (AQ) on earnings management practices (EMP) and company value (CV), as well as the mediating role of EMP in the link between AQ and CV. It presents new factual proof from the Jordanian market, which is still in its early stages.

Design/methodology/approach
A pattern of 43 service firms listed on the Amman Stock Exchange (ASE) was collected for the timeframe (2012–2019), giving an amount of 344 firm-year observances. The data was collected from the annual reports extracted from the ASE’s database and tested with panel data analysis.

Findings
The results show that audit firm industry specialization positively affects EMP while its size and tenure do not, which implies that its industry specialization does not restrict earnings management but rather leads to an increase in opportunistic behaviors. Audit firm size and audit firm industry specialization positively affect CV, whilst audit firm tenure does not. Additionally, the findings indicate that EMP negatively affect CV, and EMP act as a mediator for the AQ–CV nexus.

Research limitations/implications
Stakeholders can use the findings to enhance the capacity and effectiveness of Jordan’s fiscal market. For example, our results will boost policymakers’ eagerness to institute suitable statutes improving Jordan’s fiscal market performance. Besides, the results can assist existing and potential investors make sound adjudication by using AQ proxies and earnings management as signals to predict future company’s value.

Originality/value
The paper differentiates itself from previous papers through initiating a new proposed model by exploring the role of earnings management as a mediator in the nexus between AQ and CV by presenting new factual proof from the Jordanian market.
Circular economy practices in the leather products industry toward waste valorization: an approach of sustainable environmental management
Authors: Maliha Mysha , Moktadir Md. Abdul , Bag Surajit , Stefanakis Alexandros I. 
Published: April 2023

PurposeThe global resolution of embracing dynamic and intertwined production systems has made it necessary to adopt viable systems like circular economy (CE) to ensure excellency in the business. However, in emerging countries, it is challenging to implement the CE practices due to the existing problems in the supply chain network, as well as due to the vulnerable financial condition of the business after the deadly hit of COVID-19. The main aim of this research is to determine the barriers to implementing CE considering the recent pandemic and suggest strategies to organizations to ensure CE for a cleaner environment and greener economy.Design/methodology/approachAfter an extensive literature review and validation from experts, 24 sub-barriers under the class of 6 main barriers are finalized by Pareto analysis, which is further analyzed via the best-worst method to determine the weight and rank of the barriers Further, fuzzy-Technique for Order of Preference by Similarity to Ideal Solution (TOPSIS) method is used to rank the proposed startegies to overcome the analysed barriers.FindingsThe results identified “unavailability of initial funding capital”, “need long time investment”, “lack of integrating production system using advance technology” and “lack of strategic planning” as the most acute sub-barriers to CE implementation. Further, fuzzy TOPSIS method is used to suggest the best strategy to mitigate the ranked barriers. The results indicated “integrated design facility to CE”, “ensuring large scale funding for CE facility” as the best strategy.Practical implicationsThis study will motivate managers to implement CE practices to enjoy proper utilization of the resources, sustainable benefits in business, and gain competitive advantage.Originality/valuePeriodically, a lot of work is done on CE practices but none of them highlighted the issues in the domain of the leather products industry (LPI) and COVID-19 toward achieving sustainability in production and consumption. Thus, some significant barriers and strategies to implement CE for achieving sustainability in LPI are highlighted in this study, which is a unique contribution to the literature.
Agility assessment framework for modular and offsite construction
Authors: Salama Tarek , Said Hisham 
Published: April 2023

Purpose
The purpose of this paper is to determine if companies in the modular and offsite construction (MOC) industry are agile or not and its level of application for agility principles, which allows for quick responses to the increasingly dynamic nature of industry environments.

Design/methodology/approach
This paper proposes an agility assessment framework for MOC that uses 48 assessment attributes organized into four categories: metrics, drivers, enablers and capabilities. A questionnaire approach was used to disseminate the framework globally in 19 countries and synthesize its relevance to the MOC industry. The questionnaire had 55 complete responses, majority of respondents work in managerial positions for MOC manufacturing facilities and onsite general contractors.

Findings
It was found that the lowest metric score for adapting to change was for cost since controlling cost would be difficult for any changes required after the design freeze stage. The top agility driver was found to be the need to respond to the wide variety of customer expectations, while the lowest driver was the existence of competing priorities. The top agility enabler was vendor partnership, which can be related to current postpandemic supply chain disruptions. Regarding technological capabilities, Europe and the USA acquired better scores compared to Asia, Latin America and Africa.

Originality/value
This study contributes to the MOC body of knowledge by creating an agility assessment tool for MOC firms to analyze their agile approach and environment, identifying the preliminary importance of agility assessment attributes and determining significant agile differences between the main MOC industry groups.
How does corporate hypocrisy reduce customer co-creation behaviors? Moderated mediation analysis of corporate reputation and self-brand connection
Authors: Jung Chang Mo , Hur Won-Moo 
Published: April 2023

PurposeCustomer co-creation behaviors significantly affect a firm's performance and sustainable growth. This study tested the mediating role of corporate reputation in the relationship between corporate hypocrisy and two types of customer co-creation behaviors: customer citizenship behavior and customer participation behavior. The study also investigated the moderating effect of self-corporate brand connection on the corporate hypocrisy–corporate reputation relationship and the indirect relationship between corporate hypocrisy and customer co-creation behavior through corporate reputation.Design/methodology/approachThe authors conducted a two-wave research survey with 346 Korean bank customers and tested our hypotheses using PROCESS Macro.FindingsCorporate reputation mediated the relationship between corporate hypocrisy and customer citizenship/participant behavior. The negative effect of corporate hypocrisy on corporate reputation was more pronounced when self-corporate brand connection was high. Self-corporate brand connection further moderated the indirect effect of corporate hypocrisy on customer citizenship/participant behavior through corporate reputation.Originality/valueThe results clearly explain how corporate hypocrisy affects customer co-creation behavior. This study advances corporate hypocrisy and corporate reputation research by proposing and verifying a moderated mediation model.
Preparedness for chemical, radiologic and nuclear incidents among a sample of emergency physicians' and general practitioners'—a qualitative study
Authors: Gyllencreutz Lina , Carlsson Carl-Pontus , Karlsson Sofia , Hedberg Pia 
Published: April 2023

PurposeThis study describes preparedness of emergency physicians and general practitioners following chemical, radiological and nuclear incidents.Design/methodology/approachFive emergency physicians and six general practitioners were interviewed individually, and data was analysed using qualitative content analysis.FindingsThe study results showed that physicians' preparedness for chemical, radiological and nuclear incidents is linked to one main category: to be an expert and to seek expertise and two categories: preparations before receiving CRN patients, and physical examination and treatment of CRN patients with subcategories.Research limitations/implicationsThe results have implications for further research on the complexity of generalist vs specialist competence and knowledge when responding to chemical, radiological and nuclear incidents.Originality/valueThis study provides insights regarding chemical, radiological and nuclear preparedness among physicians at emergency departments and primary healthcare centres.
The impact of Covid-19 pandemic on the value relevance of cash flows: evidence from banks
Authors: Abou-El-Sood Heba 
Published: April 2023

PurposeThis paper is motivated by the ongoing debate on the value relevance of cash flow statement (CFS) between bank regulators, on one hand, and accounting standard setters, on the other hand. The importance and usefulness of cash flows during economic turmoil exacerbated by the Covid-19 pandemic has recently gained attention. Hence, this paper investigates the impact of Covid-19 pandemic on the value relevance of cash flows (CF) beyond accounting earnings and book equity.Design/methodology/approachA panel of 236 bank-year observations is examined for value relevance in emerging capital markets of Gulf Cooperation Council (GCC) countries. Using value relevance regression, operating and non-operating CF items are tested for value relevance beyond earnings and book value of equity during the periods 2018–2019 (pre-pandemic) and 2020–2021 (pandemic).FindingsThere is limited value relevance of CF beyond accounting earnings and the book value of equity. The distinction between operating and non-operating CF is not informative. However, the value relevance is significant during the pandemic, indicating that investors rely on CF for valuation purposes at times of uncertainty, corroborating further research on CF distress predictive ability.Originality/valueThis paper provides novel evidence on value relevance of CF and its superiority to accounting earnings and equity values during times of uncertainty. It extends a small body of research in the banking sector in emerging markets. Hence, it complements prior literature and has practical implications to accounting standard setters and bank regulators in emerging markets.
Barriers to supply chain performance measurement during disruptions such as the COVID-19 pandemic
Authors: Fares Naila , Lloret Jaime 
Published: April 2023

PurposeAmid the outbreak of coronavirus disease 2019 (COVID-19), supply chains have faltered. This has influenced operational and financial performance and lead to uncertainty in supply and distribution. Therefore, systems measuring supply chain risk and disruption management performance have gained interest. This study explores barriers to supply chain performance measurement during disruptions such as COVID-19.Design/methodology/approachBased on a survey and literature review, the authors formalise the barriers and rank them using the Decision-Making Trial and Evaluation Laboratory (DEMATEL) fuzzy Višekriterijumsko kompromisno rangiranje (VIKOR) methodology. A total of 14 experts in 11 countries were surveyed. Performance measurement is based on a balanced scorecard.FindingsFifteen barriers are identified. Based on DEMATEL analysis, the cause–effect relationships among the four scorecard aspects are explored. The customer axis is revealed as the cause, while the financial, internal business and learning/development are identified as the effect of the supply chain performance measurement. Fuzzy VIKOR calculations show that uncertainty of investment, disrupted cash flows and the bullwhip effect are the most critical barriers to measure supply chain performance during outbreaks such as the COVID-19 pandemic.Research limitations/implicationsThe study identifies and ranks general barriers; additional research is required to differentiate barriers in specific industrial sectors.Practical implicationsThe findings may help develop proactive, resilient supply chain performance strategies to overcome disruptions.Social implicationsPolicy-makers and decision-makers in industrial and service firms can explore these findings to inform strategies for robust supply chains that can resist disruption in risky environments.Originality/valueThis research addresses a knowledge gap in barriers to measure supply chain performance in post-pandemic areas. It is unclear how far firms will measure supply chain performance in terms of learning from disruption patterns, managing financial and customer demand processes in light of COVID-19. This study contributes by explaining the influences among the barriers and exploring them, offering insights from multiple stakeholders.
Antecedents of digital supply chains for a circular economy: a sustainability perspective
Authors: Dwivedi Ashish , Chowdhury Priyabrata , Agrawal Dindayal , Paul Sanjoy Kumar , Shi Yangyan 
Published: April 2023

PurposeA digital supply chain (DSC) positively enhances circular economy (CE) practices. However, what factors and conditions lead to the implementation of DSC for transitioning toward CE is not yet clear. Therefore, this study aims at identifying and subsequently analyzing the antecedents of DSC for CE.Design/methodology/approachThe study identifies major antecedents of DSC for CE to achieve sustainability objectives through literature review and expert opinions. In this study, 19 potential antecedents of DSCs for CE are established from the literature and suggestions from industry professionals. A trapezoidal fuzzy Decision-Making Trial and Evaluation Laboratory (DEMATEL) approach is applied quantitatively to investigate the antecedents identified.FindingsConducted in the context of Indian automobile manufacturing industry, the findings of the study reflect that advanced information sharing arrangement, effective government policies for DSC and CE implementation and digitalizing the supply chains are the top three potential antecedents of DSC for a CE.Originality/valueIn the existing literature, few studies are specific to investigating the DSC and CE paradigm. The present study will help organizations develop a practical and integrated strategic approach that will foster DSC through improved knowledge of CE.
The effects of AI service quality and AI function-customer ability fit on customer's overall co-creation experience
Authors: Yang Xue 
Published: April 2023

PurposeThe application of artificial intelligence (AI) in the customer market has completely changed customer behaviors. This study aims to investigate the customers' co-creation experiences with AI in the digital age.Design/methodology/approachAn online survey was used to collect data from 699 customers who had used AI-enabled banking services. Hypotheses were validated using partial least squares modeling.FindingsThe findings indicate that the customer response capabilities (e.g. perceived response expertise and perceived response speed) serve as the intermediate processes between the AI service quality and the overall co-creation experience with AI. Moreover, AI function-customer ability fit negatively moderates the direct relationship between the AI service quality and the overall co-creation experience with AI.Originality/valueThis study improves the current understanding of co-creation by investigating the human–machine co-creation (e.g. customer–AI co-creation) instead of human–human co-creation.