bluuebunny/crossref_metadata_2025_split huggingface dataset:
Probabilistic derivation of droplet velocity using quadrature method of moments
Authors: Jasim Noor M. 
Published: July 2023

Abstract
Accurately prediction of dispersion and polydispersity of droplet flow is not a trivial task due to the complex behavior of the droplet size distribution (DSD) and the strong state of the instantaneous velocity of a droplet on the shape and size of the droplet. Describing the distribution of sizes and velocities of droplets initially formed in sprays is an essential piece of information needed in spray modeling, which is used to define the initial state of the spray droplets in the downstream two-phase flow fields’ predictive computations. The predictive model for the droplet size and velocity distributions in sprays is formulated as the droplet’s velocity magnitude has a power–law relationship with the droplet in this study. The present model incorporates the deterministic and stochastic aspects of the spray formation process. The quadrature method of moments (QMOM) is applied to solve numerically the transport equations of the probability density function coupled with conserved source terms incompressible Navier-Stokes equations for the liquid phase. The sub-models are connected by different source terms signifying the liquid-gas interaction. Equations of transport for spray moments are derived from DSD, and closure is attained using a gamma distribution. The integer spray moments concerning the volume are used to construct the continuous distribution of QMOM. In contrast, the velocity moments are used to determine the droplet velocity as a constant function of the droplet diameter. The model is first applied to simulate a diesel spray tip penetration under nonreactive conditions with different droplet velocity profiles to validate the approach with experimental data. An additional case of a liquid nitrogen spray is applied to show the gamma distribution’s ability to describe spray drop size distribution. The model generally predicts reasonable agreement with the experimental for both cases.
Hydrodynamic comparison of different geometries of square cross-section airlift bioreactor using computational fluid dynamics
Authors: Esperança Mateus N. , Cerri Marcel O. , Mazziero Vítor T. , Béttega Rodrigo , Badino Alberto C. 
Published: July 2023

Abstract
The hydrodynamics of airlift bioreactors, which offer an interesting alternative to conventional stirred-tank bioreactors, has generally been evaluated using experimental approaches, requiring time, energy, and reagents. However, computational fluid dynamics (CFD) has emerged as an important and valuable tool for the analysis and design of these devices, saving time and experimental effort, while providing a large amount of information. In this study, four geometries of a square cross-section 10-L split airlift bioreactor operating with distilled water were simulated using CFD, and the hydrodynamics variables gas hold-up and liquid velocity were evaluated. CFD satisfactorily predicted the hydrodynamic parameters, when compared to experimental data, allowing adequate prediction of the shear rate distribution in airlift bioreactors. The results indicated that different shear rate distributions were obtained by geometric modifications in the bioreactor, showing that its design should be considered to satisfy different specific bioprocess requirements.
A LATÊNCIA DOS SENTIDOS NA PULSAÇÃO DA HISTÓRIA. OS SENTIDOS DA COLONIZAÇÃO
Authors: Orlandi Eni Puccinelli 
Published: July 2023

Desenvolvendo o tema tratado no livro Terra à vista, retomo a análise dos processos de significação que estão na base dos efeitos de sentidos da colonização. Apontando para o movimento próprio aos sentidos ainda não experimentados e os que se colocaram como fundadores de nossa(s) identidade(s), elaboro uma reflexão que busca ser sensível à pulsação da história em seu real. Para isso, visito as fronteiras da memória e do esquecimento nas falas que seguem seus caminhos, nos discursos sobre e dos brasileiros, e sobre o Brasil. Sentidos latentes, que se tensionam entre a estabilidade e o equívoco.
THE ROLE OF NARRATIVE STRUCTURE IN THE ACQUISITION OF EUROPEAN PORTUGUESE PERFECTIVE AND IMPERFECTIVE MORPHOLOGY BY L1 MANDARIN CHINESE LEARNERS
Authors: Yang Aoran , Zhu Linke 
Published: July 2023

The study of the acquisition of L2 tense-aspect and the development of aspectual distinctions has been conducted according to various theoretical hypotheses, among which the Discourse Hypothesis stands out nowadays. In order to examine the relationship between the use of perfective/imperfective morphology and the narrative grounding, the present study is oriented by three research questions: (1) what is the temporal base like in the past narratives produced by L1 Mandarin Chinese learners of European Portuguese? (2) is the choice of perfective and imperfective verbal morphology influenced by the narrative grounding? (3) do the learners of different proficiency levels mark the narrative grounding with different verbal forms? On the basis of a quantitative analysis on the data collected from the narratives produced by 12 L1 Mandarin Chinese learners of European Portuguese, the results revealed that the temporal base for narratives is clearly perfective-imperfective and that the foreground was mostly marked by the perfective morphology, whereas the imperfective tended to be used to mark the background, irrespective of the learners’ proficiency levels.
ENGRAILED‐1 transcription factor has a paracrine neurotrophic activity on adult spinal α‐motoneurons
Authors: Lebœuf Mélanie , Vargas‐Abonce Stephanie E , Pezé‐Hedsieck Eugénie , Dupont Edmond , Jimenez‐Alonso Lucia , Moya Kenneth L , Prochiantz Alain 
Published: July 2023

AbstractSeveral homeoprotein transcription factors transfer between cells and regulate gene expression, protein translation, and chromatin organization in recipient cells. ENGRAILED‐1 is one such homeoprotein expressed in spinal V1 interneurons that synapse on α‐motoneurons. Neutralizing extracellular ENGRAILED‐1 by expressing a secreted single‐chain antibody blocks its capture by spinal motoneurons resulting in α‐motoneuron loss and limb weakness. A similar but stronger phenotype is observed in the Engrailed‐1 heterozygote mouse, confirming that ENGRAILED‐1 exerts a paracrine neurotrophic activity on spinal cord α‐motoneurons. Intrathecal injection of ENGRAILED‐1 leads to its specific internalization by spinal motoneurons and has long‐lasting protective effects against neurodegeneration and weakness. Midbrain dopaminergic neurons express Engrailed‐1 and, similarly to spinal cord α‐motoneurons, degenerate in the heterozygote. We identify genes expressed in spinal cord motoneurons whose expression changes in mouse Engrailed‐1 heterozygote midbrain neurons. Among these, p62/SQSTM1 shows increased expression during aging in spinal cord motoneurons in the Engrailed‐1 heterozygote and upon extracellular ENGRAILED‐1 neutralization. We conclude that ENGRAILED‐1 might regulate motoneuron aging and has non‐cell‐autonomous neurotrophic activity.
Assessing treatment adherence is crucial to determine adequacy of mineralocorticoid therapy
Authors: Pofi Riccardo , Bonaventura Ilaria , Duffy Joanne , Maunsell Zoe , Shine Brian , Isidori Andrea M , Tomlinson Jeremy W 
Published: July 2023

Background
There is no consensus strategy for mineralocorticoid (MC) therapy titration in patients with primary adrenal insufficiency (PAI). We aim to measure serum fludrocortisone (sFC) and urine fludrocortisone (uFC) levels and to determine their utility, alongside clinical/biochemical variables and treatment adherence to guide MC replacement dose titration.

Methods
Multi-centre, observational, cross-sectional study on 41 patients with PAI on MC replacement therapy. sFC and uFC levels (measured by liquid chromatography-tandem mass spectrometry), plasma renin concentration (PRC), electrolytes (Na+, K+), mean arterial blood pressure (MAP), total daily glucocorticoid (dGC) and MC (dMC) dose, and assessment of treatment adherence were incorporated into statistical models.

Results
We observed a close relationship between sFC and uFC (r = 0.434, P = 0.005) and between sFC and the time from the last fludrocortisone dose (r = −0.355, P = 0.023). Total dMC dose was related to dGC dose (r = 0.556, P < 0.001), K+ (r = −0.388, P = 0.013) as well as sFC (r = 0.356, P = 0.022) and uFC (r = 0.531, P < 0.001). PRC was related to Na+ (r = 0.517, P < 0.001) and MAP (r = −0.427, P = 0.006), but not to MC dose, sFC or uFC. Regression analyses did not support a role for sFC, uFC or PRC measurements and confirmed K+ (B = −44.593, P = 0.005) as the most important variable to guide dMC titration. Of the patients, 32% were non-adherent with replacement therapy. When adherence was inserted into the regression model, it was the only factor affecting dMC.

Conclusions
sFC and uFC levels are not helpful in guiding dMC titration. Treatment adherence impacts on clinical variables used to assess MC replacement and should be included as part of routine care in patients with PAI.
Lymphangioleiomyomatosis: where endocrinology, immunology and tumor biology meet
Authors: Gibbons Erin , Minor Briaunna M N , Hammes Stephen R 
Published: July 2023

Graphical abstract

Abstract
Lymphangioleiomyomatosis (LAM) is a cystic lung disease found almost exclusively in genetic females and caused by small clusters of smooth muscle cell tumors containing mutations in one of the two tuberous sclerosis genes (TSC1 or TSC2). Significant advances over the past 2–3 decades have allowed researchers and clinicians to more clearly understand the pathophysiology of LAM, and therefore better diagnose and treat patients with this disease. Despite substantial progress, only one proven treatment for LAM is used in practice: mechanistic target of rapamycin complex 1 (mTORC1) inhibition with medications such as sirolimus. While mTORC1 inhibition effectively slows LAM progression in many patients, it is not curative, is not effective in all patients, and can be associated with significant side effects. Furthermore, the presence of established and accurate biomarkers to follow LAM progression is limited. That said, discovering additional diagnostic and treatment options for LAM is paramount. This review will describe recent advances in LAM research, centering on the origin and nature of the LAM cell, the role of estrogen in LAM progression, the significance of melanocytic marker expression in LAM cells, and the potential roles of the microenvironment in promoting LAM tumor growth. By appreciating these processes in more detail, researchers and caregivers may be afforded novel approaches to aid in the treatment of patients with LAM.
“faces negras na escola” – interseccionalidade, interculturalidade, interdisciplinaridade e direitos humanos
Authors: Silva Cláudio Rodrigues da 
Published: July 2023

Trata-se de resenha do livro publicado pela Appris, em 2020, intitulado Interdisciplinaridade, interculturalidade e interseccionalidade: faces negras na escola, organizado pelas Profas. Dras. Ana M. Klein, Cláudia M. C. Nigro e Monica A. Galindo, do Instituto de Biociências, Letras e Ciências Exatas (Ibilce) da Universidade Estadual Paulista (Unesp), São José do Rio Preto.
¿Cómo se promueve la competencia matemática en los libros de texto de educación infantil?: un análisis de la demanda cognitiva
Authors: Vásquez Claudia , Pincheira Nataly , Alsina Ángel 
Published: July 2023

En este trabajo se presenta el análisis de las tareas matemáticas presentes en libros de texto chilenos para la educación infantil. Para ello, hemos optado por un enfoque cualitativo de carácter descriptivo utilizando como método de investigación la técnica de análisis de contenido para analizar y describir la demanda cognitiva de las tareas matemáticas propuestas en los libros de texto. Nos centramos en la demanda cognitiva de las tareas matemáticas propuestas, puesto que gran parte del aprendizaje está condicionado por el tipo de tareas que se plantean a los niños, por tanto, es un elemento clave para favorecer el desarrollo de la competencia matemática desde edades tempranas. Los resultados muestran la presencia de tareas vinculadas a la memorización y a procedimientos con conexión. De ello se desprende que es necesario que el profesorado cuente con los conocimientos disciplinares y didácticos que le permitan enriquecer las tareas que se presentan en los libros de texto para favorecer que los niños, a través del andamiaje colectivo, coconstruyan y reconstruyan nuevos conocimientos y desarrollen gradualmente la competencia matemática.
Constraining and pushing factors of integration of the Eurasian Economic Union in the context of the latest challenges of the global economy
Authors: Moga Irina , Gorbunova Lyudmila , Denisova Arina , Pizhurina Ekaterina , Presnova Irina 
Published: July 2023

This article analyzes the main constraining and pushing factors that determine the degree of intensity of integration processes within the framework of the Eurasian Economic Union (EAEU). The assessment of the motives, opportunities and contradictions of the participating countries related to further integration seems to the authors relevant primarily for the reason that under the current conditions their role in the world economy, the direction and nature of foreign economic relations have undergone significant changes upon joining the Union and today. Accordingly, every day, depending on the external agenda, the balance of advantages and disadvantages of participation in the integration association also changes. The main driver of the association is still the desire to increase the effectiveness of the national socio-economic policy to ensure the growth of the quality of life and well-being of the population. At the same time, the strategy of using the advantages of geographical proximity with a state with a more developed market economy, the availability of financial, technological and managerial resources and the common goal of being an equal part of the world economic system, under the influence of unprecedented sanctions pressure, the system is changing its architecture. The driving force of integration is the need to resist the economic restrictions applied by the United States and EU countries against Russia.
In the first part, the authors analyzed the constraining factors of integration associated with the asymmetric nature of the Union. The authors analyze the changing attitude towards Russia as a locomotive of integration, the impact of its close cooperation with China on the other members of the Union, the declarative nature of the documents regulating the stages of integration, the hybrid nature of governance, the weakness of the supranational judicial system, the synchronous devaluation of national currencies.
In the second part of the article, as stimulating factors, the authors consider the dynamically developing common labor market, freedom of movement and a single market of goods, the potential for the development of international transit traffic in conditions of disruption of traditional supply chains.
Understanding the current factors influencing the integration processes in the EAEU will allow identifying possible ways of their development and developing an adequate strategy for optimizing the overall institutional environment in the EAEU space, contributing to the achievement of the goals set by the participating countries on mutually beneficial terms for them.
HAK ISTRI DALAM HUBUNGAN SEKSUAL MENURUT HUKUM KELUARGA ISLAM
Authors: Aeni Azmi Ro'yal , Alhizbi Maulana Ni'ma 
Published: July 2023

In marital relations, one of which is sexual relations, Islam puts forward the principles of equality between husband and wife, but in reality, women often treated unfriendly and prone to not fulfilling their rghts, one of which is the right to enjoy sexual relations. This study aims to understand the right to enjoy sexual relations for women in Islam an its relation to communication in marriage, as well as the exposure of ‘aqd tamlik and ‘aqd ibahah in marriage. The research method used in this research s library research with a normative approach. The result of this research is that culture has formed male superiority in sexual relations. Religious texts need to be accompanied by good communication in marriage as bridge for the creation of good husband and wife relatons. ‘Aqd tamlik is marriage with concept of a contract of ownership (the husband owns the wife completely), ‘aqd ibahah means the concept of marriage involving an agreement between the two parties.
Keywords: Women's Rights; Marriage Communication; Islamic Family Law
ANALISIS STRUKTUR GEDUNG DPRD KOTA BUKITTINGGI MENGGUNAKAN SNI BETON BERTULANG 2847:2019 DAN SNI GEMPA 1726:2019
Authors: Medriosa Hamdeni , Wirahadi Kusuma Wau Antonius 
Published: July 2023

Perancangan struktur merupakan unsur yang penting pada pembangunan suatu gedung agar dapat menghasilkan gedung yang kuat, aman dan ekonomis. Secara keseluruhan struktur bangunan gedung terdiri dari dua bagian yaitu struktur bagian atas yang berupa lantai, balok, kolom, dinding dan atap sedangkan struktur bagian bawah berupa pondasi. Bangunan Gedung DPRD kota Bukittinggi ini akan dianalisa menggunakan sistem Struktur Rangka Pemikul Momen Khusus (SRPMK) berdasarkan tata cara perhitungan struktur beton bertulang menggunakan (SNI 2847-2019). Analisis beban gempa menggunakan metode respon spektrum berdasarkan tata cara perencanaan ketahanan gempa untuk struktur bangunan gedung dan non gedung menggunakan (SNI 1726-2019). Analisa Beban desain minimum dan kriteria terkait untuk bangunan gedung dan struktur lain menggunakan (SNI 1726-2020). Pemodelan pada penelitian ini menggunakan software berbasis finite elemen 3D menggunakan SAP2000. Hasil penelitian ini menjelaskan bahwa pemodelan memenuhi persyaratan terhadap desain gempa SNI-1726-2019 dan desain beton bertulang SNI 03-2847-2019.
Photocatalytic degradation of Emtricitabine, Lamivudine, and Tenofovir in water using the UV/TiO2/H2O2 hybrid system
Authors: Zvinowanda Caliphs , Ncube Pauline , Ntuli Freeman 
Published: July 2023

Abstract
This study was aimed at investigating the removal of antiretroviral (ARV) drug residues of emtricitabine (FTC), lamivudine (LVD), and Tenofovir (TFV) from water using the UV/TiO2/H2O2 hybrid system. Evaluations of operational factors, degradation kinetics, scavenger effects, degradation pathways, and reusability of the catalyst were the key objectives of the study. The central composite design (CCD) of the response surface methodology (RSM) was used for statistical analysis and process optimization. Five variables (pH, pollutant concentration, TiO2 loading, H2O2 dosage and time) were optimized. The removal realized was 92.56% (FTC), 91.67% (LVD), and 94.83% (TFV) respectively under optimum conditions. The degradations obeyed the pseudo-first-order model with the rate constant (k1) of 0.10773 min− 1 (FTC), 0.0513 min− 1 (TFV,) and 0.04756 min− 1 (LVD). pH and H2O2 had positive influence on pollutant removals up to optimum conditions. The •OH and h+ were the major contributors to pollutant degradations. The degradation of target compounds in water has not yet been reported using the UV/TiO2/H2O2, as far as the authors are aware. Moreover, the reaction kinetics and degradation pathway of FTC and TFV have not yet been studied. The research shows that the UV/TiO2/H2O2 hybrid system may provide an alternative treatment method for the ARVs in water.
Genomic epidemiology of SARS-CoV-2 from Uttar Pradesh, India
Authors: Misra Gauri , Manzoor Ashrat , Upadhyay Archana , Katiyar Amit , Bhushan Brij , Anvikar Anup , Chopra Meenu 
Published: July 2023

Abstract
The various strains and mutations of SARS-CoV-2 have been tracked using several forms of genomic classification systems. The present study reports high-throughput sequencing and analysis of 99 SARS-CoV-2 specimens from UP-west using sequences obtained from the GISAID database, followed by phylogeny and clade classification. Phylogenetic analysis revealed that Omicron lineages BA-2-like (55.55%) followed by Delta lineage-B.1.617.2 (45.5%) were predominantly circulating in this area Signature substitution at positions S: N501Y, S: D614G, S: T478K, S: K417N, S: E484A, S: P681H, and S: S477N were commonly detected in the Omicron variant-BA-2-like, however S: D614G, S: L452R, S: P681R and S: D950N were confined to Delta variant-B.1.617.2. We have also identified three escape variants in the S gene at codon position 19 (T19I/R), 484 (E484A/Q), and 681 (P681R/H) during the fourth and fifth waves in India. Based on the phylogenetic diversification studies and similar changes in other lineages, our analysis revealed indications of convergent evolution as the virus adjusts to the shifting immunological profile of its human host. Our knowledge to date indicates that this study is the first attempt that comprehensively maps the circulating SARS-CoV-2 strains from Western UP using an integrated approach of whole genome sequencing and phylogenetic analysis.
A critical role for cortical amygdala circuitry in shaping social encounters
Authors: Russo Scott , Aubry Antonio , Durand-de Cuttoli Romain , Fisher-Foye Rachel , Parise Lyonna , Cathomas Flurin , Burnett C , Yang Yewon , yuan chongzhen , Lablanca Alexa , Chan Kenny , Lin Hsiao-yun , Froemke Robert , Li Long 
Published: July 2023

Abstract

Aggression is an evolutionarily conserved behavior that controls social hierarchies and protects valuable resources like mates, food, and territory. In mice, aggressive behaviour can be broken down into an appetitive phase, which involves approach and investigation, and a consummatory phase, which involves biting, kicking, and wrestling. By performing an unsupervised weighted correlation network analysis on whole-brain c-Fos expression, we identified a cluster of brain regions including hypothalamic and amygdalar sub-regions and olfactory cortical regions highly co-activated in male, but not female aggressors (AGG). The posterolateral cortical amygdala (COApl), an extended olfactory structure, was found to be a hub region based on the number and strength of correlations with other regions in the cluster. Our data further show that estrogen receptor 1 (ESR1)-expressing cells in the COApl exhibit increased activity during attack behaviour, and during bouts of investigation which precede an attack, in male mice only. Chemogenetic or optogenetic inhibition of COApl ESR1 cells in AGG males reduces aggression and increases pro-social investigation without affecting social reward/reinforcement behavior. We further confirmed that COApl ESR1 projections to the ventrolateral portion of the ventromedial hypothalamus and central amygdala are necessary for these behaviours. Collectively, these data suggest that in aggressive males, COApl ESR1 cells respond specifically to social stimuli, thereby enhancing their salience and promoting attack behaviour.