bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of a Physical-Psychological Integrative (PPI) intervention for community-dwelling spinal cord injury survivors: Study protocol of a preliminary randomized controlled trial
Authors: Li Yan , Wong Arnold , Chung Wai Man , Li Mengqi , Molasiotis Alex , Bressington Daniel , Ma Christina Zong-Hao , Kor Patrick Pui Kin , Yeung Wing Fai 
Published: March 2023

Introduction
There is a considerably large group of community-dwelling spinal cord injury (SCI) survivors living with low quality of life. Physical inactivity, depression, and chronic pain are major problems faced by SCI survivors discharged from the acute phase of treatment or inpatient rehabilitation. This study aims to evaluate the feasibility, acceptability, and preliminary effects of a Physical-Psychological Integrative (PPI) online group intervention on community-dwelling SCI survivors’ physical activity, depression, and chronic pain.

Methods
This is a two-arm pilot randomized controlled trial with repeated measures (pre-, post-intervention, and 3-month follow-up) design. Seventy-two participants will be randomly assigned to two study groups. The PPI intervention group will receive a video program for physical activity training and eight-week online group psychological interventions using skills of group-based motivational interviewing and mindfulness-based stress reduction. The control group will receive an eight-week online didactic education programed. Focus-group interviews will be conducted post-intervention to explore their views about acceptance and suggested improvements to the intervention. The feasibility of study procedures and the acceptability of interventions will be evaluated. The effectiveness of the PPI intervention will be evaluated by leisure-time physical activity, depression, chronic pain, exercise efficacy, mindfulness, and quality of life. We will use the generalized estimating equation to assess intervention effects and content analysis for interview data. This study has received ethical approval from the Hong Kong Polytechnic University (HSEARS20210705004) and was registered in ClinicalTrials.gov (NCT05535400).

Discussion
This study will be the first to provide empirical data on the evaluation of an online-group intervention integrating both physical activity promotion and psychological approaches, aimed at reducing physical inactivity, depression, and chronic pain for community-dwelling SCI survivors in Hong Kong. The findings could provide evidence supporting the use of PPI intervention as a novel online group support, in addressing both the physical and psychological needs of community-dwelling SCI survivors.
Individuals with a Family History of Colorectal Cancer Warrant Tailored Interventions to Address Patient-Reported Barriers to Screening
Authors: Jain Shailavi , Galoosian Artin , Wilhalme Holly , Meshkat Sarah , May Folasade P. 
Published: March 2023

STRUCTURED ABSTRACT

Introduction:
Population health interventions to increase colorectal cancer (CRC) screening rates often exclude individuals with a family history of CRC, and interventions to increase screening in this high-risk group are rare. We aimed to determine the screening rate and barriers and facilitators to screening in this population to inform interventions to increase screening participation.

Methods:
We performed a retrospective chart review and cross-sectional survey of patients excluded from mailed fecal immunochemical test (FIT) outreach due to a family history of CRC in a large health system. We used Chi-square, Fisher’s exact, and Student’s t-tests to compare demographic and clinical characteristics of individuals overdue and not overdue for screening. We then administered a survey (mailed and telephone) to overdue patients to assess barriers and facilitators to screening.

Results:
There were 296 patients excluded from mailed FIT outreach and 233 had a confirmed family history of CRC. Screening participation was low (21.9%), and there were no significant demographic or clinical differences between those overdue and not overdue for screening. There were 79 survey participants. Major patient-reported barriers to screening colonoscopy were patient forgetfulness (35.9%), fear of pain during colonoscopy (17.7%), and hesitancy about bowel preparation (29.4%). To facilitate screening colonoscopy, patients recommended reminders (56.3%), education about familial risk (50%), and colonoscopy education (35.9%).

Conclusions:
Patients with a family history of CRC that are excluded from mailed FIT outreach have low screening rates and report multiple mutable barriers to screening. They warrant targeted efforts to increase screening participation.
Filtrations of numerically flat Higgs bundles and curve semistable Higgs bundles on Calabi–Yau varieties
Authors: Bruzzo Ugo , Capasso Armando 
Published: March 2023

Abstract
We consider Higgs bundles satisfying a notion of numerical flatness (H-nflatness) that was introduced in [5; 4], and show that they have Jordan-Hölder filtrations whose quotients are stable, locally free and H-nflat. This is applied to show that curve semistable Higgs bundles on simply connected Calabi–Yau varieties have vanishing discriminant.
The Dissatisfied Skeptic in Kant’s Discipline of Pure Reason
Authors: Goldhaber Charles 
Published: March 2023

AbstractWhy does Kant say that a “skeptical satisfaction of pure reason” is “impossible” (A758/B786)? I answer this question by giving a reading of “The Discipline of Pure Reason in Respect of Its Polemic Employment.” I explain that Kant must address skepticism in this context because his warning against developing counterarguments to dogmatic attacks encourages a comparison between the critical and the skeptical methods. I then argue that skepticism fails to “satisfy” [befriedigen] reason insofar as it cannot “pacify” reason’s tendency to go beyond its own boundaries. The skeptical method reveals the past failures of dogmatic metaphysics but cannot rule out future successes. Only critical knowledge of reason’s proper bounds can do this, thereby pacifying our restless reason. I close by arguing that Kant’s discussion implies that a skeptic must feel dissatisfied with her renunciation of metaphysics, and that this dissatisfaction can lead her to take interest in Kant’s critical philosophy.
In-Fill Asymptotic Distribution of the Change Point Estimator when Estimating Breaks One at a Time
Authors: Tayanagi Toshikazu , Kurozumi Eiji 
Published: March 2023

Abstract
In this study, we investigate the least squares (LS) estimator of a structural change point by the in-fill asymptotic theory, which has been recently used by Jiang, Wang, and Yu (2018. “New Distribution Theory for the Estimation of Structural Break Point in Mean.” Journal of Econometrics 205 (1): 156–76; 2020. “In-Fill Asymptotic Theory for Structural Break Point in Autoregressions.” Econometric Reviews 40 (4): 359–86), when the model with two structural changes is estimated as the model with only a one-time structural change. We, hence, show that the finite sample distribution of the estimator of the first break has four peaks, which is different from the classical long-span asymptotic distribution, which contains only one peak. Conversely, the in-fill asymptotic distribution of the estimator has four peaks and can approximate the finite sample distribution very well. We also demonstrate that the estimator is consistent in the in-fill asymptotic framework with a relatively large magnitude of the break. In the latter case, the finite sample distribution of the estimator has only one peak and is well approximated by both the in-fill and long-span asymptotic theory.
News exposure and Americans’ perceptions of China in 2019 and 2021
Authors: Tang Shuo , Willnat Lars 
Published: March 2023

Abstract

Purpose
The relationship between China and the United States has been in freefall in recent years. Both the Covid-19 pandemic and the U.S.-China trade war contributed to more negative perceptions of China among the American public. This study analyzes how Americans’ news consumption and personal traits affected their general perceptions of China before and after the outbreak of Covid-19 in 2020 to explore how major international events might influence people’s perceptions of foreign nations.

Design/methodology/approach
This study relied on data from two national online surveys conducted in the United States in early 2019 (N = 1,250) and 2021 (N = 1,237). Both surveys measure the respondents’ media use, personal traits, and their perceptions of China.

Findings
The findings indicate that perceptions of China were mostly shaped by exposure to partisan and social media—rather than consumption of mainstream news media. However, these relationships were significantly stronger in 2021 than in 2019, pointing to a growing influence of the U.S. news media in U.S.-China relations. This study also found that partisanship and personal traits were strong predictors of Americans’ attitudes toward China.

Practical implications
Researchers can learn from this study which variables should be included in surveys that focus on public perceptions of foreign affairs.

Social implications
This study shows that media effects and personal traits interact in complex ways to shape Americans’ perceptions of China.

Originality/value
This study analyzes and compares data from two national representative samples, offering insights into how major international events might influence public opinion. It also measures the possible impact of the Chinese social media platform TikTok on Americans’ perceptions of China.
Study on the impulse mechanism of optical films formed by laser plasma shock waves
Authors: Wang Guixia , Su Junhong 
Published: March 2023

Abstract
In a high-power laser system, when the surface pressure of the optical film caused by laser plasma shock wave is greater than the adhesion per unit area of the film layer, the film will produce mechanical damage, and in serious cases, the whole system may not work. Therefore, studying the formation mechanism of optical film surface pressure and impulse caused by laser plasma shock wave is the key to ensure the normal operation of the high-power laser system. In this article, by studying the relaxation process of laser plasma shock wave on the surface pressure of optical film, and using the time accumulation effect of various pressures on the surface of the optical film, the calculation model of impulse on the optical film’s surface formed by laser plasma shock waves was established, and the variation rules of the impulse

I

st

{I}_{\text{st}}

and impulse coefficient

j

j

on the unit area of single-layer Al2O3 and HfO2 optical films with different parameters were obtained. When the incident laser wavelength

λ

\lambda

was 1,064 nm, the energy

E

E

was

0.1

J

0.1\hspace{.1em}\text{J}

, the pulse width

t

p

{t}_{\text{p}}

was

10

ns

10\hspace{.25em}\text{ns}

, the focal length of the focusing lens

f

f

was

350

mm

350\hspace{.25em}\text{mm}

, the distance between the film surface and the focal plane of the focusing lens

z

0

{z}_{0}

was

5

mm

5\hspace{.5em}\text{mm}

, and the film radius

R

R

was

5

mm

5\hspace{.5em}\text{mm}

, the calculation and simulation results show that the impulse

I

st

{I}_{\text{st}}

of the two films was

1

0

−
4

N

s

1{0}^{-4}\hspace{.5em}\text{N}\hspace{.5em}\text{s}

order of magnitude, the impulse coefficient j of the two films was

1

0

−
5

N

s/J

1{0}^{-5}\hspace{.5em}\text{N}\hspace{.5em}\text{s/J}

, the Al2O3 film with small atomic number will obtain larger

I

st

{I}_{\text{st}}

and

j

j

,

I

st

{I}_{\text{st}}

and

j

j

of the two films increase with the increase of

E

E

and

f

f

, and

I

st

{I}_{\text{st}}

and

j

j

of the two films decrease with the increase of

z

0

{z}_{0}

and

t

p

{t}_{\text{p}}

. In the total impulse transfer time (

t

0

{t}_{0}

),

I

st

{I}_{\text{st}}

and

j

j

both increase with the increase of

R

R

.
Average or unique – Polish place-names and word-initial consonant groups
Authors: Jaskuła Krzysztof 
Published: March 2023

AbstractPlace-names occupy a special area in the vocabulary of the Polish language. Their shape occasionally differs to a greater or lesser extent from that of words which constitute the bulk of the lexicon. They have been investigated in terms of semantics and etymology by various linguists, but their phonological analysis is only occasionally provided. In this paper, word-initial consonant combinations found in Polish place-names are presented and analysed from the viewpoint of Government Phonology in its most recent version called Complexity Scales and Licensing. The analysis, covering bi-consonantal, tri-consonantal and tetra-consonantal clusters, will be conducted with a view to finding out how the model shows the possible governing relationships between consonants. Of specific interest is the question of whether these toponyms are totally peculiar or just normal in terms of the phonotactics of the Polish language.
Identification of potential inhibitors of thymidylate synthase (TS) (PDB ID: 6QXH) and nuclear factor kappa-B (NF–κB) (PDB ID: 1A3Q) from Capsicum annuum (bell pepper) towards the development of new therapeutic drugs against colorectal cancer (CRC)
Authors: Olajide Monsurat , Abdul-Hammed Misbaudeen , Bello Isah Adewale , Adedotun Ibrahim Olaide , Afolabi Tolulope Irapada 
Published: March 2023

Abstract
Colorectal cancer is the third most deadly cancer globally. Drug resistance and attendant side effects make the available standard anti-colorectal cancer drugs against target receptors inefficient. Phytochemicals from medicinal plants are safer, cheaper, effective, and heal diseases from the cellular level. This study is aimed at identifying potential inhibitors of thymidylate synthase (TS) and nuclear factor kappa-B (NF–κB) target receptors from Capsicum annuum towards the development of new therapeutic drugs against colorectal cancer via in silico approach. One hundred and fifty (150) ligands previously reported from Capsicum annuum were downloaded from the PubChem database and were subjected to chemo-informatics analyses such as ADMET, drug-likeness, oral bioavailability, bioactivity, and PASS prediction to ascertain their therapeutic and safety profile before docking. The ligands that passed the analyses were docked against TS and NF–κB in duplicate using a creditable docking tool (PyRx). Raltitrexed and emetine were used as the standard drug inhibitors for TS and NF–κB, respectively. The results obtained from this study showed that feruloyl-beta-D-glucose (8.45 kcal/mol), 5-O-caffeoylquinic acid (−8.40 kcal/mol), 5-O-caffeoylquinic acid methyl ester (−7.89 kcal/mol), feruloyl hexoside (−7.40 kcal/mol), O-glucopyranoside (−7.55 kcal/mol), and quercetin (−7.00 kcal/mol) shared the same binding pocket with TS while feruloyl-beta-D-glucose (−7.00 kcal/mol), chlorogenic acid (−6.90 kcal/mol), 5-O-caffeoylquinic acid (−6.90 kcal/mol) and feruloyl hexoside (−6.50 kcal/mol) shared the same pocket with NF–κB. These compounds were selected as best hits due to their excellent inhibitory efficiency and chemoinformatic profiles. Thus, the compounds may function as prospective lead compounds for developing a new anti-colorectal cancer drug.
Tailoring the optical and UV reflectivity of CFRP-epoxy composites: Approaches and selected results
Authors: Haiden Lukas , Brunner Andreas J. , Pansare Amol V. , Feuchter Michael , Pinter Gerald 
Published: March 2023

Abstract
Specific nano- and micro-scale morphologies of composites can affect the resulting optical and UV reflectivity of the materials. One example is “Vantablack®” made from aligned carbon nanotubes (CNTs) with 99.96% absorption. A similar material with CNTs grown on surface-activated aluminum (CNTs/sa-Al) even yielded 99.995% absorption, one order of magnitude higher than Vantablack®. On the other hand, fresh snow reflects 90% or more of the incident electromagnetic radiation with wavelengths between 400 and 1,000 nm. The reflectivity of snow originates from multiple scattering in the porous morphology made of snow grains. Taking these complex morphologies as inspiration, CFRP epoxy composites with different types, sizes, shapes, and amount of nanoparticles are prepared and compared regarding their optical and ultraviolet (UV) reflectivity. Increasing the reflectivity in the near and far UV may be beneficial for the durability of the epoxy composites, but selective higher or lower reflectivity in certain wavelength ranges may also yield tailored visual effects. Results from different processing approaches with selected nanoparticles are presented and discussed.
Stress‐sensitive dynamics of miRNAs and Elba1 in Drosophila embryogenesis
Authors: Örkenby Lovisa , Skog Signe , Ekman Helen , Gozzo Alessandro , Kugelberg Unn , Ramesh Rashmi , Magadi Srivathsa , Zambanini Gianluca , Nordin Anna , Cantú Claudio , Nätt Daniel , Öst Anita 
Published: March 2023

AbstractEarly‐life stress can result in life‐long effects that impact adult health and disease risk, but little is known about how such programming is established and maintained. Here, we show that such epigenetic memories can be initiated in the Drosophila embryo before the major wave of zygotic transcription, and higher‐order chromatin structures are established. An early short heat shock results in elevated levels of maternal miRNA and reduced levels of a subgroup of zygotic genes in stage 5 embryos. Using a Dicer‐1 mutant, we show that the stress‐induced decrease in one of these genes, the insulator‐binding factor Elba1, is dependent on functional miRNA biogenesis. Reduction in Elba1 correlates with the upregulation of early developmental genes and promotes a sustained weakening of heterochromatin in the adult fly as indicated by an increased expression of the PEV wm4h reporter. We propose that maternal miRNAs, retained in response to an early embryonic heat shock, shape the subsequent de novo heterochromatin establishment that occurs during early development via direct or indirect regulation of some of the earliest expressed genes, including Elba1.
Interferon-λ contributes to endometrial receptivity
Authors: Yao Kezhen , Sun Yu , Ye Xiaoqun , Wu Ying 
Published: March 2023

In brief
IFN-λs participate in the fetal–maternal immune interaction, involving in immune regulation, uterine receptivity, cell migration and adhesion, and endometrium apoptosis. Our study helps to elucidate the underlying causes of the IFN-λs deficiency to spontaneous pregnancy loss in women.

Abstract
Immunotherapy has been commonly used to prevent recurrent pregnancy loss in women with inadequate uterus receptivity or immunological imbalance. Many immune regulators are now identified as having crucial roles at the embryo–maternal interface. However, the clinical efficacy of immunity-related markers during the peri-implantation period remains to be explored in depth. Here, we demonstrated that endometrial expression of interferon-λ (IFN-λ), regarded as a newer class of interferons, is aberrantly lower in women who suffered from recurrent implantation failure than that in fertile control. We further uncovered genetic and biochemical evidence that IFN-λ is induced directly by estrogen in the endometrial cells, and IFN-λ pathway may play multiple roles involving the inflammatory response, uterine receptivity, cell migration, and blastocyst adhesion. Furthermore, we indicated IFN-λ lessens the sensitivity of endometrium to FASL-mediated apoptosis. In addition to uncovering this IFN-λ as a novel nonredundant regulator that participates in the fetal–maternal immune interaction, our study helps to elucidate the underlying causes of spontaneous pregnancy loss in women.
Multicenter Study of High-Flow Nasal Cannula Initiation and Duration of Use in Bronchiolitis
Authors: Byrd Courtney , Noelck Michelle , Kerns Ellen , Bryan Mersine , Hamline Michelle , Garber Matthew , Ostrow Olivia , Riss Valerie , Shadman Kristin , Shein Steven , Willer Robert , Ralston Shawn 
Published: March 2023

BACKGROUND AND OBJECTIVES
There is a paucity of multicenter data on rates of high flow nasal cannula (HFNC) usage in bronchiolitis in the United States, largely because of the absence of standardized coding, with HFNC often subsumed into the larger category of noninvasive mechanical ventilation.

METHODS
We examined HFNC utilization in patients with bronchiolitis from a sample of hospitals participating in a national bronchiolitis quality improvement collaborative. Medical records of patients aged &lt;2 years admitted November 2019 to March 2020 were reviewed and hospital-specific bronchiolitis policies were collected. Exclusion criteria were prematurity &lt;32 weeks, any use of mechanical ventilation, and presence of comorbidities. HFNC utilization (including initiation, initiation location, and treatment duration), and hospital length of stay (LOS) were calculated. HFNC utilization was analyzed by individual hospital HFNC policy characteristics.

RESULTS
Sixty-one hospitals contributed data on 8296 patients; HFNC was used in 52% (n = 4286) of admissions, with the most common initiation site being the emergency department (ED) (75%, n = 3226). Hospitals that limited HFNC use to PICUs had reduced odds of initiating HFNC (odds ratio, 0.3; 95% confidence interval [CI], 0.3 to 0.4). Hospitals with an ED protocol to delay HFNC initiation had shorter HFNC treatment duration (−12 hours; 95% CI, −15.6 to −8.8) and shorter LOS (−14.9 hours; 95% CI, −18.2 to −11.6).

CONCLUSIONS
HFNC was initiated in &gt;50% of patients admitted with bronchiolitis in this hospital cohort, most commonly in the ED. In general, hospitals with policies to limit HFNC use demonstrated decreased odds of HFNC initiation, shorter HFNC duration, and reduced LOS compared with the study population.
Experimental investigation on replacement of PET aggregate as fine aggregate and water hyacinth as bio plasticizer in concrete
Authors: Daisy Angel Priya I. , Akshaya S. , Harsha Neya S. , Vanitha S. , Karthigai Priya P. , Johnson J Nittin 
Published: March 2023

AbstractUsage of single use plastics has been rapidly increasing in the recent past and it is challenging to dispose of these plastics safely, since they are non-biodegradable. Especially, Polyethylene Terephthalate (PET) which is widely used in the form of water bottles cannot be easily recycled or reused. On the other hand, construction projects require sustainable materials having good strength, accordingly various studies have been conducted to reuse plastic wastes in the concrete and positive results have been obtained. In this study, the crushed PET bottles are partially substituted with fine aggregates and water hyacinth is added as a bio plasticizer in concrete. The concrete specimens are cast by substituting PET aggregates with the fine aggregates at 2, 4, 6, 8, 10% and water hyacinth is added at 10 & 20% by weight of water. The specimens are tested and it is noted that with the addition of PET aggregates up to 4% the strength of the concrete increases and beyond 4%, strength of the concrete gradually decreases, and addition of water hyacinth enhances the strength of the concrete.