bluuebunny/crossref_metadata_2025_split huggingface dataset:
Aqueous Two‐Phase Emulsion Bioresin for Facile One‐Step 3D Microgel‐Based Bioprinting
Authors: Wang Qingbo , Karadas Özge , Backman Oskar , Wang Luyao , Näreoja Tuomas , Rosenholm Jessica M. , Xu Chunlin , Wang Xiaoju 
Published: March 2023

AbstractMicrogel assembly as void‐forming bioinks in 3D bioprinting has evidenced recent success with a highlighted scaffolding performance of these bottom‐up biomaterial systems in supporting the viability and function of the laden cells. Here, a ternary‐component aqueous emulsion is established as a one‐step strategy to integrate the methacrylated gelatin (GelMA) microgel fabrication and assembly through vat photopolymerization in situ using digital light processing (DLP)‐based bioprinting. The as‐proposed aqueous emulsion is featured with the partitioning of a secondary photo‐crosslinkable polysaccharide, methacrylated galactoglucomannan (GGMMA) derived from plant source in both the dispersed phase of GelMA droplets and the continuous phase of dextran (Dex). As an emulgator, GGMMA renders enhanced stability of the aqueous emulsion bioresins. Strategically, the photo‐crosslinkable GGMMA adheres the GelMA microgels that are conveniently converted from emulsion droplets to form hydrogel construct in layer‐by‐layer curing to accommodate the laden cells directly mixed in the aqueous emulsion. The spatially interconnected void space left by the removal of Dex benefits the cell growth under the guidance of the microgel surface and supports cell colonization within the macroscopic porous hydrogel. This work amends a low‐concentration and cost‐effective bioresin that is highly applicable for facilely fabricating microgel assembly as a porous hydrogel construct in DLP‐based bioprinting.
Near‐Theoretical Thermal Conductivity Silver Nanoflakes as Reinforcements in Gap‐Filling Adhesives
Authors: Chen Lu , Liu Te‐Huan , Wang Xiangze , Wang Yandong , Cui Xiwei , Yan Qingwei , Lv Le , Ying Junfeng , Gao Jingyao , Han Meng , Yu Jinhong , Song Chengyi , Gao Jinwei , Sun Rong , Xue Chen , Jiang Nan , Deng Tao , Nishimura Kazuhito , Yang Ronggui , Lin Cheng‐Te , Dai Wen 
Published: March 2023

AbstractThe rapid development of highly integrated microelectronic devices causes urgent demands for advanced thermally conductive adhesives (TCAs) to solve the interfacial heat‐transfer issue. Due to their natural 2D structure and isotropic thermal conductivity, metal nanoflakes are promising fillers blended with polymer to develop high‐performance TCAs. However, achieving corresponding TCAs with thermal conductivity over 10 W m−1K−1at filler content below 30 vol% remains challenging so far. This longstanding bottleneck is mainly attributed to the fact that most current metal nanoflakes are prepared by “bottom‐up” processes (e.g., solution‐based chemical synthesis) and inevitably contain lattice defects or impurities, resulting in lower intrinsic thermal conductivities, only 20–65% of the theoretical value. Here, a “top‐down” strategy by splitting highly purified Ag foil with nanoscale thickness is adopted to prepare 2D Ag nanoflakes with an intrinsic thermal conductivity of 398.2 W m−1K−1, reaching 93% of the theoretical value. After directly blending with epoxy, the resultant Ag/epoxy exhibits a thermal conductivity of 15.1 W m−1K−1at low filler content of 18.6 vol%. Additionally, in practical microelectronic cooling performance evaluations, the interfacial heat‐transfer efficiency of the Ag/epoxy achieves ≈1.4 times that of the state‐of‐the‐art commercial TCA.
A Nitroxide Radical Conjugated Polymer as an Additive to Reduce Nonradiative Energy Loss in Organic Solar Cells
Authors: Shi Furong , Guo Pengzhi , Qiao Xianfeng , Yao Guo , Zhang Tao , Lu Qi , Wang Qian , Wang Xiaofeng , Rikhsibaev Jasurbek , Wang Ergang , Zhang Chunfeng , Kwon Young‐Wan , Woo Han Young , Wu Hongbin , Hou Jianhui , Ma Dongge , Armin Ardalan , Ma Yuguang , Xia Yangjun 
Published: March 2023

AbstractNonfullerene‐acceptor‐based organic solar cells (NFA‐OSCs) are now set off to the 20% power conversion efficiency milestone. To achieve this, minimizing all loss channels, including nonradiative photovoltage losses, seems a necessity. Nonradiative recombination, to a great extent, is known to be an inherent material property due to vibrationally induced decay of charge‐transfer (CT) states or their back electron transfer to the triplet excitons. Herein, it is shown that the use of a new conjugated nitroxide radical polymer with 2,2,6,6‐tetramethyl piperidine‐1‐oxyl side groups (GDTA) as an additive results in an improvement of the photovoltaic performance of NFA‐OSCs based on different active layer materials. Upon the addition of GDTA, the open‐circuit voltage (VOC), fill factor (FF), and short‐circuit current density (JSC) improve simultaneously. This approach is applied to several material systems including state‐of‐the‐art donor/acceptor pairs showing improvement from 15.8% to 17.6% (in the case of PM6:Y6) and from 17.5% to 18.3% (for PM6:BTP‐eC9). Then, the possible reasons behind the observed improvements are discussed. The results point toward the suppression of the CT state to triplet excitons loss channel. This work presents a facile, promising, and generic approach to further improve the performance of NFA‐OSCs.
COAP‐Palladium‐Catalyzed Asymmetric Linear Allylic Alkylation of Vinyl Benzoxazinanones for Multifunctional 3,3′‐Disubstituted Oxindole Derivatives
Authors: Shen Jun‐Hao , Zhou Sheng‐Suo , Wang Bai‐Lin , Liu Wen‐Kai , Wang Zheng , Wang Xing‐Wang 
Published: March 2023

AbstractA Pd‐catalyzed enantioselective linear‐allylic alkylation of vinyl benzoxazinanones with a series of 3‐substituted oxindoles was reported in the presence of a chiral oxamide‐phosphine ligand (COAP−Bn) under mild reaction conditions. A series of optically active multifunctional 3,3′‐disubstituted oxindole derivatives bearing a quaternary stereogenic center and a linear aryl amino side chain were respectively obtained in 55–98% yields with 96–99% ee for 3‐(hetero)aryl substituted oxindoles. The developed protocol demonstrates that the COAP ligands could serve as a privileged chiral ligand to construct diverse chiral 3,3‐disubstituted oxindole compounds with various quaternary stereogenic centers, such as aza‐, thio‐ or all‐carbon quaternary stereogenic centers. The salient features of the method include broad substrate scope, N‐protecting group free, base‐free, and high regio‐ and enantioselectivity.magnified image
AQP4 Aggravates Cognitive Impairment in Sepsis‐Associated Encephalopathy through Inhibiting Nav1.6‐Mediated Astrocyte Autophagy
Authors: Zhu Dan‐Dan , Huang Yue‐Lin , Guo Song‐Yu , Li Na , Yang Xue‐Wei , Sui Ao‐Ran , Wu Qiong , Zhang Yue , Kong Yue , Li Qi‐Fa , Zhang Ting , Zheng Wen‐Fei , Li Ai‐Ping , Yu Jian , Ma Tong‐Hui , Li Shao 
Published: March 2023

AbstractThe pathology of sepsis‐associated encephalopathy (SAE) is related to astrocyte‐inflammation associated with aquaporin‐4 (AQP4). The aim here is to investigate the effects of AQP4 associated with SAE and reveal its underlying mechanism causing cognitive impairment. The in vivo experimental results reveal that AQP4 in peripheral blood of patients with SAE is up‐regulated, also the cortical and hippocampal tissue of cecal ligation and perforation (CLP) mouse brain has significant rise in AQP4. Furthermore, the data suggest that AQP4 deletion could attenuate learning and memory impairment, attributing to activation of astrocytic autophagy, inactivation of astrocyte and downregulate the expression of proinflammatory cytokines induced by CLP or lipopolysaccharide (LPS). Furthermore, the activation effect of AQP4 knockout on CLP or LPS‐induced PPAR‐γ inhibiting in astrocyte is related to intracellular Ca2+ level and sodium channel activity. Learning and memory impairment in SAE mouse model are attenuated by AQP4 knockout through activating autophagy, inhibiting neuroinflammation leading to neuroprotection via down‐regulation of Nav1.6 channels in the astrocytes. This results in the reduction of Ca2+ accumulation in the cell cytosol furthermore activating the inhibition of PPAR‐γ signal transduction pathway in astrocytes.
Ultra‐Low Dosage Lignin Binder for Practical Lithium–Sulfur Batteries
Authors: Chen Zhuzuan , Lu Mingjin , Qian Yong , Yang Yu , Liu Ju , Lin Zhan , Yang Dongjie , Lu Jun , Qiu Xueqing 
Published: March 2023

AbstractPolymeric binders stabilize lithium–sulfur (Li–S) batteries by suppressing the shuttle of lithium polysulfide (LiPS) and volume variation, but the dosage of state‐of‐the‐art binders in sulfur cathodes (≈20 wt%) hinders the electron/ion transfer and decreases the cell‐specific density. Here, a wood‐inspired lignin binder is developed after modification with amino acids for practical Li–S batteries at ultra‐low low dosage (2 wt%). Benefiting from strong and balanced adhesions with active/conductive/current collector materials, robust mechanical properties, and super LiPS anchoring capability, the Li–S cell delivers an initial discharge capacity of 864 mAh g−1 at 0.5 C and can readily operate 1000 cycles. Moreover, the pouch cell with high mass loading (4.75 mg cm−2) also delivers a high energy density of 484 Wh kg−1. This work provides important guidance in binder design for the sulfur cathode and paves a new way for the practical application of Li–S batteries.
Are people's daily life habits consistent with their preference for food sustainability labels?
Authors: Nian Yefan , Gao Zhifeng , Zhao Ruojin 
Published: March 2023

AbstractIdentifying the factors correlating to consumers' preference for sustainability‐labeled food products is essential for developing policies to promote the consumption of food produced in a socially responsible and environmentally friendly manner. Using a representative US consumer sample, this study systematically examines consumers' preferences for different food sustainability labels and investigates whether consumers' life habits in other domains of life are consistent with their food purchasing decisions. We find that among the four food sustainability labels included in our study, consumers have the highest marginal willingness‐to‐pay (MWTP) for United States Department of Agriculture certified organic labels, followed by the nongenetically modified organism, eco‐friendly, and fair‐trade labels. It is evident that daily activities, such as proenvironmental behaviors away from home and physical exercise in everyday life, are correlated to consumers' MWTP for sustainability‐labeled food products. This study provides implications for designing proper strategies to improve sustainable food consumption, including targeting consumers who adopt a more environmentally sustainable lifestyle, such as conducting proenvironmental activities outside home and physical exercise activities in daily life. [EconLit Citations: Q13, Q18].
Prospective evaluation of plasma phosphorylated tau in a real‐life memory clinic in Thailand
Authors: Thanapornsangsuth Poosanu , Booncharoen Kittithatch , Luechaipanit Watayuth , Supharatpariyakorn Thirawat , Sarutikriangkri Yuthachai , Tangnimitchok Suchart , Likitjaroen Yuttachai , Sukprakun Chanan , Tepmongkol Supatporn , Hemachudha Thiravat 
Published: March 2023

AbstractIntroductionDespite the substantial accuracy of plasma p‐tau in diagnosing Alzheimer's disease (AD) in research cohorts, data on real‐life memory clinic patients are lacking.MethodsMemory clinic patients at their early symptomatic stages were prospectively enrolled to undergo routine clinical assessment, plasma p‐tau181 quantification (Simoa), amyloid and tau‐positron emission tomography (PET). The diagnostic performance of plasma p‐tau181, neurocognitive specialists, and regional tau‐PET were compared head‐to‐head using amyloid‐PET as the reference standard.ResultsPlasma p‐tau181 has the area under the curve (AUC), sensitivity, specificity, and accuracy of 0.84 (95% confidence interval [CI] 0.73–0.94), 0.80 (95% CI 0.64–0.90), 0.75 (95% CI 0.51–0.90), and 0.78 (95% CI 0.65–0.88) for detecting amyloid‐PET positivity in early symptomatic patients, respectively. The AUC of clinical diagnosis and tau‐PET were 0.70 (95% CI 0.56–0.85) and 0.88 (95% CI 0.79–0.97), respectively.DiscussionPlasma p‐tau181 also performed well in real‐life memory clinic settings and its role in clinical practice is supported.
Bio‐inspired Structure‐editing Fluorescent Hydrogel Actuators for Environment‐interactive Information Encryption
Authors: Wang Ruijia , Zhang Yi , Lu Wei , Wu Baoyi , Wei Shuxin , Wu Shuangshuang , Wang Wenqin , Chen Tao 
Published: March 2023

AbstractMany living organisms have the superb structure‐editing capacity for better adaptation in dynamic environments over the course of their life cycle. However, it's still challenging to replicate such natural structure‐editing capacity into artificial hydrogel actuating systems for enhancing environment‐interactive functions. Herein, we learn from the metamorphosis development of glowing octopus to construct proof‐of‐concept fluorescent hydrogel actuators with life‐like structure‐editing capacity by developing a universal stepwise inside‐out growth strategy. These actuators could perform origami‐like 3D shape deformation and also enable the postnatal growth of new structures to adapt additional actuating states for different visual information delivery by using different environment keys (e.g., temperature, pH). This study opens previously unidentified‐avenues of bio‐inspired hydrogel actuators/robotics and extends the potential uses for environment‐interactive information encryption.
Structural and Morphological Transformations of Covalent Organic Nanotubes
Authors: Koner Kalipada , Karak Suvendu , Ogaeri Yutaro , Nishiyama Yusuke , Banerjee Rahul 
Published: March 2023

AbstractCovalent organic nanotubes (CONTs) are porous one‐dimensional frameworks connected through imine bonds via Schiff base condensation between aldehydes and amines. The presence of two amine groups at the ortho position in the structurally demanding tetraaminotriptycene (TAT) building block leads to multiple reaction pathways between the ditopic aldehyde and the tetratopic amine. We have synthesized five different monomers of CONT‐1 by the Schiff base condensation reaction between TAT and o‐anisaldehyde. The conversion of imine to imidazole bonding in a monomer is probed using NMR, mass spectrometry, and X‐ray diffraction techniques. Solid‐state NMR provide insights into the CONTs’ structural connectivity. A theoretical investigation suggests that the π‐π stacking could be the driving force for rapid imine to imidazole conversion within the CONT‐1. Microscopic imaging sheds further light on the self‐assembly process of the CONTs, indicating both head‐to‐head and side‐by‐side assembly.
Magnetism in Nonplanar Zigzag Edge Termini of Graphene Nanoribbons
Authors: Xu Xiushang , Sun Kewei , Ishikawa Atsushi , Narita Akimitsu , Kawai Shigeki 
Published: March 2023

AbstractGraphene nanoribbons (GNRs) and nanographenes synthesized by on‐surface reactions using tailor‐made molecular precursors offer an ideal playground for a study of magnetism towards nano‐spintronics. Although the zigzag edge of GNRs has been known to host magnetism, the underlying metal substrates usually veil the edge‐induced Kondo effect. Here, we report the on‐surface synthesis of unprecedented, π‐extended 7‐armchair GNRs using 7‐bromo‐12‐(10‐bromoanthracen‐9‐yl)tetraphene as the precursor. Characterization by scanning tunneling microscopy/spectroscopy revealed unique rearrangement reactions leading to pentagon‐ or pentagon/heptagon‐incorporated, nonplanar zigzag termini, which demonstrated Kondo resonances even on bare Au(111). Density functional theory calculations indicate that the nonplanar structure significantly reduces the interaction between the zigzag terminus and the Au(111) surface, leading to a recovery of the spin localization of the zigzag edge. Such a distortion of planar GNR structures offers a degree of freedom to control the magnetism on metal substrates.
Spectroscopic Identification of Active Sites of Oxygen‐Doped Carbon for Selective Oxygen Reduction to Hydrogen Peroxide
Authors: Liu Longxiang , Kang Liqun , Chutia Arunabhiram , Feng Jianrui , Michalska Martyna , Ferrer Pilar , Grinter David C. , Held Georg , Tan Yeshu , Zhao Fangjia , Guo Fei , Hopkinson David G. , Allen Christopher S. , Hou Yanbei , Gu Junwen , Papakonstantinou Ioannis , Shearing Paul R. , Brett Dan J. L. , Parkin Ivan P. , He Guanjie 
Published: March 2023

AbstractThe electrochemical synthesis of hydrogen peroxide (H2O2) via a two‐electron (2 e−) oxygen reduction reaction (ORR) process provides a promising alternative to replace the energy‐intensive anthraquinone process. Herein, we develop a facile template‐protected strategy to synthesize a highly active quinone‐rich porous carbon catalyst for H2O2 electrochemical production. The optimized PCC900 material exhibits remarkable activity and selectivity, of which the onset potential reaches 0.83 V vs. reversible hydrogen electrode in 0.1 M KOH and the H2O2 selectivity is over 95 % in a wide potential range. Comprehensive synchrotron‐based near‐edge X‐ray absorption fine structure (NEXAFS) spectroscopy combined with electrocatalytic characterizations reveals the positive correlation between quinone content and 2 e− ORR performance. The effectiveness of chair‐form quinone groups as the most efficient active sites is highlighted by the molecule‐mimic strategy and theoretical analysis.
Overcoming the Oxygen Dilemma in Photoredox Catalysis: Near‐Infrared (NIR) Light‐Triggered Peroxynitrite Generation for Antibacterial Applications
Authors: Shen Zhiqiang , Zheng Shaoqiu , Fang Yuanmeng , Zhang Guoying , Zhu Chen , Liu Shiyong , Hu Jinming 
Published: March 2023

AbstractThe peroxynitrite anion (ONOO−) is closely associated with many diseases and the creation of ONOO− donors is an essential means of understanding its pathophysiological functions. However, it is challenging to develop ONOO− donors due to the difficulties in simultaneously producing highly reactive and short‐lived nitric oxide (NO) and superoxide anion (O2⋅−). Here, we report a novel strategy for constructing ONOO− donors by combining near‐infrared (NIR)‐mediated type I photosensitization and photoredox catalysis. The key design using a Nile blue analogue that can serve as both a type I photosensitizer and a metal‐free photocatalyst. Intriguingly, the formation of O2⋅− via type I photosensitization avoids oxygen interference and instead activates nitrobenzofurazan‐based NO donors via oxygen‐tolerant NIR photoredox catalysis. The simultaneous release of O2⋅− and NO leads to ONOO− release, showing both antibacterial and antibiofilm activities.
Glucose‐Responsive Charge‐Switchable Lipid Nanoparticles for Insulin Delivery
Authors: Liu Yun , Wang Yanfang , Yao Yuejun , Zhang Juan , Liu Wei , Ji Kangfan , Wei Xinwei , Wang Yuanwu , Liu Xiangsheng , Zhang Shiming , Wang Jinqiang , Gu Zhen 
Published: March 2023

AbstractLipid nanoparticle‐based drug delivery systems have a profound clinical impact on nucleic acid‐based therapy and vaccination. Recombinant human insulin, a negatively‐charged biomolecule like mRNA, may also be delivered by rationally‐designed positively‐charged lipid nanoparticles with glucose‐sensing elements and be released in a glucose‐responsive manner. Herein, we have designed phenylboronic acid‐based quaternary amine‐type cationic lipids that can self‐assemble into spherical lipid nanoparticles in an aqueous solution. Upon mixing insulin and the lipid nanoparticles, a heterostructured insulin complex is formed immediately arising from the electrostatic attraction. In a hyperglycemia‐relevant glucose solution, lipid nanoparticles become less positively charged over time, leading to reduced attraction and subsequent insulin release. Compared with native insulin, this lipid nanoparticle‐based glucose‐responsive insulin shows prolonged blood glucose regulation ability and blood glucose‐triggered insulin release in a type 1 diabetic mouse model.
Diastereoselective Synthesis of Monofluorocyclohexenes through Photocatalyzed Cascade Cyclization of gem‐Difluoroalkenes and α,β‐Unsaturated Carbonyl Compounds
Authors: Li Zhengyu , Zhang Yizhi , Zhang Yunxiao , He Xingyi , Shen Xiao 
Published: March 2023

AbstractMonofluoroalkenes are nonhydrolyzable mimetics of amides. Previous work focused on the synthesis of non‐cyclic monofluoroalkenes. However, diastereoselective synthesis of monofluorocyclohexenes from non‐cyclic substrates is challenging. Herein, we report the first photocatalyzed cascade cyclization reactions of readily available α,β‐unsaturated carbonyl compounds and gem‐difluoroalkenes for the synthesis of highly functionalized monofluorocyclohexenes. The reaction shows broad substrate scope with high diastereoselectivity (>30 examples, up to 86 % yield, >20 : 1 dr). The post‐reaction transformations of the products demonstrate the synthetic potential of this methodology.
Bifunctional Iminophosphorane‐Catalyzed Enantioselective Nitroalkane Addition to Unactivated α,β‐Unsaturated Esters**
Authors: Rozsar Daniel , Farley Alistair J. M. , McLauchlan Iain , Shennan Benjamin D. A. , Yamazaki Ken , Dixon Darren J. 
Published: March 2023

AbstractHerein we describe the enantioselective intermolecular conjugate addition of nitroalkanes to unactivated α,β‐unsaturated esters, catalyzed by a bifunctional iminophosphorane (BIMP) superbase. The transformation provides the most direct access to pharmaceutically relevant enantioenriched γ‐nitroesters, utilizing feedstock chemicals, with unprecedented selectivity. The methodology exhibits a broad substrate scope, including β‐(fluoro)alkyl, aryl and heteroaryl substituted electrophiles, and was successfully applied on a gram scale with reduced catalyst loading, and, additionally, catalyst recovery was carried out. The formal synthesis of a range of drug molecules, and an enantioselective synthesis of (S)‐rolipram were achieved. Additionally, computational studies revealed key reaction intermediates and transition state structures, and provided rationale for high enantioselectivities, in good agreement with experimental results.
Topology optimization of a novel bionic fractal microchannel applied in thermal management of electronic components
Authors: Wang Yuwei , Sun Liang , Qi Cong , Yu Jie , Zhang Wenjie 
Published: March 2023

AbstractReducing energy consumption and improving device efficiency are important ways to realize efficient heat dissipation of microdevices, this paper developed a new bionic fractal microchannel heat sink based on fractal theory and topological optimization ideas, which introduced a binary flow stagnation zone optimization based on topological optimization ideas on the basic fractal microchannel. The thermal and hydraulic properties of a nanofluid in a fractal microchannel heat sink (FMCHS) have been numerically simulated with the fractal dimensions (fd = 1, 1.5, and 2) and Reynolds number (Re = 200–1600) as variables, and the comprehensive performance has been analyzed. The results showed that the introduction of the optimization increases the central velocity of the microchannel by 7.14–18.2%. With fractal dimensions of 1.5 and 2, the flow improvement and velocity increase are significant, and a significant Nusselt number improvement is obtained. The best comprehensive performance is obtained for FMCHS with a fractal dimension of 1.5, with an optimization effect of 8.3%.