bluuebunny/crossref_metadata_2025_split huggingface dataset:
Можливий підхід щодо визначення раціонального складу сил та засобів радіаційного, хімічного, біологічного захисту для виконання заходів в умовах радіоактивного та хімічного зараження
Authors: Poplavetz Serhii , Huzchenko Serhii , Vorobiov Oleh , Avramenko Oleksandr , Shumeiko Viktor 
Published: February 2023

Мета роботи: визначення раціонального складу сил та засобів радіаційного, хімічного, біологічного захисту для виконання заходів в умовах радіоактивного та хімічного зараження.
Метод: метод мережевого планування, метод комбінаторного програмування.
Результати дослідження: розроблено методику визначення раціонального складу сил та засобів радіаційного, хімічного, біологічного захисту для виконання заходів в умовах радіоактивного та хімічного зараження, яка на відміну від відомих враховує можливі сценарії радіаційної, хімічної, небезпечної обстановки, обсяги виконання заходів, складається з ряду етапів і процедур та ґрунтується на прогнозі обстановки, оптимізації мережевих графіків та комбінаторної оптимізації.
Теоретична цінність дослідження: формування та розв’язання оптимізаційної задачі мінімізації часу виконання заходів з обмеженнями на кількість сил та засобів радіаційного, хімічного, біологічного захисту військ з врахуванням можливих сценаріїв радіаційної, хімічної, небезпечної обстановки.
Тип статті: описовий та розрахунково-аналітичний.
Аналіз та оцінка факторів, які впливають на розвиток реактивних систем залпового вогню Збройних Сил України
Authors: Remez Volodymyr 
Published: February 2023

Мета роботи: це аналіз та оцінка основних факторів, що впливають на розвиток реактивних систем залпового вогню Збройних Сил України, а також порівняльний аналіз стану розвитку реактивних систем залпового вогню Росії, Білорусії та Казахстану протягом періоду (1993 – 2022 рр.).
Метод дослідження: основними методами досліджень є експертні методи, метод аналізу ієрархій, метод регресійного та кореляційного аналізу, методи статистичного аналізу та математичної статистики, методи прогнозування.
Результати дослідження: у статті визначено степені впливу факторів на розвиток реактивних систем залпового вогню Збройних Сил України за періодами їх розвитку, а також оцінено степені взаємозв’язку економічних факторів із станом розвитку озброєння та військової техніки Збройних Сил України.
Теоретична цінність дослідження: основними результатами досліджень за тематикою статті є: перелік основних зовнішніх та внутрішніх факторів, що впливають на розвиток реактивних систем залпового вогню; підхід до оцінювання степені взаємозв’язку зміни факторів та стану розвитку реактивних систем залпового вогню; вибірка статистичної інформації щодо стану фінансування розвитку озброєння та військової техніки Збройних сил України; статистична інформація щодо розвитку реактивних систем залпового вогню у Росії, Білорусії та Казахстану.
Тип статті: описовий та розрахунково-аналітичний.
Efforts to Improve Short-Distance Running Achievement Through a Play Approach in Grade VIII Students
Authors: Yoga Frederikus , Mardikaninsih Agusti 
Published: February 2023

The purpose of this study was to determine the improvement of short-distance running achievement through a play approach to class VIII students. This type of research is classroom action research (CAR), with three cycles. The instrument used is a short distance running test. The subjects in this study were class VIII students, totaling 16 students. The data analysis technique used is descriptive statistics with percentages. Based on the results of the study, the results of the Short Distance Running test through a play approach to class VIII students obtained an average achievement in cycle 1 of 64.58, an average of 71.87 in cycle 2, and an average of cycle 3 obtained 80, From these results, it can be concluded that there is an increase in Short Distance Running Achievement through a Playing Approach for Class VIII Students. In this study, I created a student performance grid in which there are several indicators that will determine student scores. The KKM value for learning sprint distance running is obtained with several assessment criteria, namely mastery of movement techniques, enthusiasm and harmony in practicing sprint running, while for the aspects assessed, namely starting attitude, body posture when running, arm swing, body posture at the finish and grades. achievement (time). To get a score above the KKM, in the learning process the teacher must be able to maximize the factors that support the achievement of the learning.
Effect of sprinting velocity on anterior cruciate ligament and knee load during sidestep cutting
Authors: Moon Jeheon , Koo Dohoon , Kim Sungmin , Panday Siddhartha Bikram 
Published: February 2023

The purpose of the study was to investigate the effect of an increase in sprinting velocity on the anterior cruciate ligament (ACL) load, knee joint load, and activation of femoral muscles using the musculoskeletal modeling approach. Fourteen high school male athletes were recruited (age: 17.4 ± 0.7 years, height: 1.75 ± 0.04 m, weight: 73.3 ± 8.94 kg), with the right foot dominant and physical activity level of about 3–4 h per day. The kinematics, kinetics, and co-contraction index (CCI) of the extensors and flexors of the right leg’s femoral muscles were calculated. The anterior cruciate ligament load was estimated using the musculoskeletal modeling method. In the results, it was observed that the anterior cruciate ligament load (p &lt; 0.017) increased as sidestep cutting velocity increased, resulting in increased adduction (p &lt; 0.017) and the internal rotation moment of the knee joint. This was significantly higher than when sprinting at a similar velocity. The co-contraction index result, which represents the balanced activation of the femoral extensor and flexor muscles, showed a tendency of decrement with increasing sprinting velocity during sidestep cutting (p &lt; 0.017), whereas no significant differences were observed when running at different sprinting conditions. Therefore, we postulate that factors such as knee joint shear force, extended landing posture with increasing sprinting velocity, internal rotation moment, and femoral muscle activity imbalance influence the increase of anterior cruciate ligament load during a sidestep cutting maneuver.
Development of the foregut and the formation of the trachea and esophagus in rat embryos. A symphony of confusion
Authors: Ginzel Marco , Huber Nana , Bauer Leopold , Kluth Dietrich , Metzger Roman 
Published: February 2023

Introduction: During embryonic development, the trachea emerges from an area of the foregut, which is often referred to as “anterior” or “common” foregut tube or simply foregut. To explain this process of differentiation, four competing models exist to date. The outgrowth and watershed models propose a foregut that remains constant in length. In the outgrowth model, the trachea buds off and elongates from the foregut, while in the watershed model, a mesenchymal wedge splits the growing foregut into the trachea and esophagus. In contrast, the septation model proposes a cranial splitting and thus a shortening of the “common” foregut tube into the trachea and esophagus by an emerging septum. Finally, the splitting and extension model describes an interaction of cranial splitting of the foregut and simultaneous caudal tracheal and esophageal growth.Methods: Here we examine the development of the undifferentiated foregut by micro computed tomography, which allows precise measurements.Results: Our results show that this area of the foregut transforms into the larynx, a process, which is independent from tracheal and esophageal development.Discussion: These observations are only consistent with the outgrowth model.
Qualitative and quantitative determination of chemical constituents in Jinbei oral liquid, a modern Chinese medicine for coronavirus disease 2019, by ultra-performance liquid chromatography coupled with mass spectrometry
Authors: Zhang Aijun , Xu Qingcui , Jiang Juanjuan , Zhao Zimo , Zhang Liangzong , Tao Kai , Cao Guiyun , Zhang Jinghua , Ding Lin , Meng Zhaoqing , Dong Wenyao , Wang Chunxia 
Published: February 2023

Introduction: Traditional Chinese medicine (TCM) has the advantages of syndrome differentiation and rapid determination of etiology, and many TCM prescriptions have been applied to the clinical treatment of coronavirus disease 2019 (COVID-19). Among them, Jinbei Oral Liquid (Jb.L) has also shown an obvious curative effect in the clinic, but the related material basic research is relatively limited.Methods: Therefore, in this process, a systematic data acquisition and mining strategy was established using ultra-high- performance liquid chromatography coupled with quadruple time-of-flight mass spectrometry (UPLC-Q-TOF-MS).Results and Discussion: With the optimized conditions, a total of 118 peaks were tentatively characterized, including 43 flavonoids, 26 phenylpropanoids, 14 glycosides, 9 phthalides, 8 alkaloids and others. To determine the content of relevant pharmacological ingredients, we firstly exploited the ultra-performance liquid chromatography method coupled with triple-quadrupole tandem mass spectrometry (UPLC-QqQ-MS/MS) method for simultaneous detection of 31 active ingredients within 17 min, and the validation of methodology showed that this method has good precision and accuracy. Moreover, analyzing the pharmacology of 31 individual of the medicinal material preliminarily confirmed the efficacy of Jb.L and laid a foundation for an in-depth study of network pharmacology.
Exploring multielement nanogranular coatings to forestall implant-related infections
Authors: Bottagisio Marta , Balzano Vincenzo , Ciambriello Luca , Rosa Laura , Talò Giuseppe , Lovati Arianna B. , De Vecchi Elena , Gavioli Luca 
Published: February 2023

IntroductionAs we approach the post-antibiotic era, the development of innovative antimicrobial strategies that carry out their activities through non-specific mechanisms could limit the onset and spread of drug resistance. In this context, the use of nanogranular coatings of multielement nanoparticles (NPs) conjugated to the surface of implantable biomaterials might represent a strategy to reduce the systemic drawbacks by locally confining the NPs effects against either prokaryotic or eukaryotic cells.MethodsIn the present study, two new multielement nanogranular coatings combining Ag and Cu with either Ti or Mg were synthesized by a gas phase physical method and tested against pathogens isolated from periprosthetic joint infections to address their potential antimicrobial value and toxicity in an in vitro experimental setting.ResultsOverall, Staphylococcus aureus, Staphylococcus epidermidis and Escherichia coli displayed a significantly decreased adhesion when cultured on Ti-Ag-Cu and Mg-Ag-Cu coatings compared to uncoated controls, regardless of their antibiotic resistance traits. A dissimilar behavior was observed when Pseudomonas aeruginosa was cultured for 30 and 120 minutes upon the surface of Ti-Ag-Cu and Mg-Ag-Cu-coated discs. Biofilm formation was mainly reduced by the active effect of Mg-Ag-Cu compared to Ti-Ag-Cu and, again, coatings had a milder effect on P. aeruginosa, probably due to its exceptional capability of attachment and matrix production. These data were further confirmed by the evaluation of bacterial colonization on nanoparticle-coated discs through confocal microscopy. Finally, to exclude any cytotoxic effects on eukaryotic cells, the biocompatibility of NPs-coated discs was studied. Results demonstrated a viability of 95.8% and 89.4% of cells cultured in the presence of Ti-Ag-Cu and Mg-Ag-Cu discs, respectively, when compared to negative controls.ConclusionIn conclusion, the present study demonstrated the promising anti-adhesive features of both Ti-Ag-Cu and Mg-Ag-Cu coatings, as well as their action in hampering the biofilm formation, highlighting the safe use of the tested multi-element families of nanoparticles as new strategies against bacterial attachment to the surface of biomedical implants.
Effect of e-health intervention on disease management in patients with chronic heart failure: A meta-analysis
Authors: Ding Xueying , Wen Yating , Tian Zimeng , Wen Yaru , Sun Guokun , Geng Rongxing , Fang Wei , Xu Yun 
Published: February 2023

ObjectiveThe aim of this meta-analysis was to assess the impact of e-health interventions on disease management in patients with CHF.MethodsSix databases including Embase, Web of Science, Scopus, PubMed, Cochrane, and EBSCO were searched by computer. The search time is before May 1, 2022. Odds ratios (OR) were used for binary categorical data and weighted mean differences (WMD) for continuous variables. The 95% confidence intervals (CI) were used to express the effect sizes for both count and measurement data. RevMan 5.4 and Stata 16.0 were employed to complete this meta-analysis.ResultsThe study included 22 research studies and 5,149 patients. e-health intervention can effectively reduce all-cause mortality [OR = 0.801, 95%CI: (0.650, 0.987), P &lt; 0.05], all-cause hospitalization rate [OR = 0.66, 95%CI: (0.46, 0.95), P &lt; 0.05] and heart failure related hospitalization rate [OR = 0.750, 95%CI: (0.632, 0.891), P &lt; 0.05]. e-health intervention is also effective in improving the quality of life [WMD = 2.97, 95%CI: (1.54, 4.40), P &lt; 0.05] and the self-management ability of patients [WMD = −2.76, 95%CI: (−5.52, −0.11), P &lt; 0.05].Conclusione-health interventions can reduce all-cause mortality, all-cause hospitalization, and heart failure-related hospitalization in patients with CHF. Furthermore, it can improve the health-related quality of life of patients.
Application of rivaroxaban in patients with non-valvular atrial fibrillation and end-stage kidney disease: A systematic review and meta-analysis
Authors: Yang Zhenzhen , Wang Jieya , Yuan Ye , Cheng Tian , Ren Feifei , Wang Songsong , Zhang Zhiqing 
Published: February 2023

BackgroundNowadays, the number of patients with non-valvular atrial fibrillation (NVAF) complicated by end-stage renal disease (ESKD) is increasing. There are significant challenges in anticoagulation with prescription drugs because of the high risk of bleeding and embolism among these patients. However, no randomized controlled trials (RCTs) of warfarin in combination with any non-vitamin K oral anticoagulant (NOACs) have been performed in patients with baseline creatinine clearance (CrCl) &lt;25 ml/min, which makes it difficult to justify the use of anticoagulants in such patients. Then, we aimed to collect and summarize all evidence to enable the anticoagulation of rivaroxaban, which is less cleared by the kidneys, in patients with severe renal insufficiency and to complement and improve the evidence on the use of rivaroxaban for anticoagulation.MethodsThe present systematic review and meta-analysis searched the databases of PubMed, Embase, the Cochrane Library, CNKI, CBM, and Google Scholar for relevant studies from inception to 1 June 2022, with the restriction of English and Chinese. Eligible cohort studies and RCTs that reported efficacy outcomes [composite of stroke and systemic embolism (SSE), ischemic stroke (ICS), and systemic embolization] or safety outcomes [major bleeding, intracranial hemorrhage (ICH), and gastrointestinal bleeding (GIB)] of rivaroxaban in NVAF patients with ESKD were enrolled. Two authors completed the data extraction and quality assessment work, respectively. The Cochrane Collaboration tool for assessing the risk of bias was used for RCTs, and the NEW-Castle Ottawa scale was used for study quality assessment for cohort studies. Dichotomous variables were calculated as risk factors with 95% confidence intervals (CIs), and meta-analysis was performed to probe the effect of research design, rivaroxaban dose, and controlled drug factors on outcomes.ResultsIn total, three studies were included for meta-analysis, involving 6,071 NVAF patients with ESKD, and two studies were included for qualitative analysis. All included studies were at low risk of bias. A meta-analysis demonstrated that mix-dose rivaroxaban caused no statistical discrepancy in the occurrence of thrombotic and bleeding events when compared to the control group (embolism, LogOR: −0.64, 95% CI: −1.05 to −0.23, P:0.25; bleeding, LogOR: −0.33, 95% CI: −0.63 to −0.03, P:0.15), and low-dose rivaroxaban produced similar results (embolism, LogOR: −1.04, 95% CI: −2.15 to 0.07, P:0.61; bleeding, LogOR: −0.81, 95% CI: −1.19 to −0.44, P:0.93).ConclusionIn this study, low-dose rivaroxaban (10 mg, once a day) may benefit more than warfarin in patients with NVAF and ESKD.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/#recordDetails, identifier CRD42022330973.
Machine learning-assisted processing workflow for multi-fiber DAS microseismic data
Authors: Ma Yuanyuan , Eaton David , Igonin Nadine , Wang Chaoyi 
Published: February 2023

In recent years, Distributed Acoustic Sensing (DAS) deployed in deviated wells has been increasingly used for microseismic monitoring. DAS can provide observations of microseismic wavefields with high spatial resolution and wide aperture, at the cost of unusually large data volumes compared with conventional downhole microseismic monitoring. To tackle this big-data challenge, we have developed key elements of a processing workflow that is assisted by machine learning techniques. We trained a convolutional neural network (CNN) for event detection and a U-Net model for both P- and S-wave arrival time picking. The workflow was applied to two multiwell DAS datasets acquired during hydraulic fracturing completions in western Canada. These datasets also include co-located 3C borehole geophone arrays that enable further comparison between catalogs from both sensor types. Compared with a traditional short-term average/long-term average (STA/LTA) method for event detection, our results indicate that the CNN method has a lower false-trigger rate and increases the event catalog size by a factor of 2.6–5.6. U-Net yields arrival-time picks with relatively small errors, high efficiency, and minimal user intervention, providing hypocenter location and focal depth that is arguably more accurate than the geophone catalog. While the proposed automated workflow requires substantial effort to build high-quality and large training datasets, it enables the use of DAS for real-time seismicity monitoring and risk management after the training stage. Although the DAS system detected fewer events than the geophone catalog and missed smaller magnitude events, our results indicate that fiber-optic sensors provide enough sensitivity to detect and locate sufficient events to characterize the treatment stages. DAS also captured induced events located at a hypocentral distance of &gt;1 km, which are possibly indicative of reactivation of structural features.
Enhanced arc magmatic productivity of the Western Pacific island arcs deduced from gravity-derived arc crustal growth rates
Authors: Parcutela N. E. , Austria R. S. , Dimalanta C. B. , Valera G. T. V. , Gabo-Ratio J. A. S. , Payot B. D. , Armada L. T. , Sangalang K. J. F. , Yumul G. P. 
Published: February 2023

Island arcs are postulated as the juvenile components that contribute to the growth of continental crust. Growth rates of arc crusts were previously computed using crustal thicknesses derived from seismic data. Consequently, crustal growth rates of oceanic island arcs are also constrained by the limited seismic data availability. This work presents the first comparison of gravity-derived magmatic growth rates of Western Pacific oceanic island arcs. We used the statistical correlation between Bouguer anomalies and seismic-derived crustal thicknesses to generate an empirical formula. The new empirical formula was utilized to estimate the crustal thicknesses of oceanic island arcs using Bouguer anomalies from the EGM2008 global gravity model. The resulting crustal thicknesses were employed to compute the magmatic growth rates of western Pacific island arcs and the Philippine island arc system. The latest magmatic growth rate estimates show that the magmatic productivity of Western Pacific island arcs, which are directly associated with Pacific Plate subduction, is significantly higher (28–60 km3/km/m.y). The growth rate of the Pacific island arcs is higher compared to the magmatic growth rate computed for the other oceanic island arcs (12–25 km3/km/m.y), which are derived from the subduction of other oceanic lithospheres (i.e., the Philippine Sea Plate; Caribbean Sea Plate; and Eurasia-South China Sea slabs). This is attributed to the variation in the ages of the subducting plates. The Pacific Plate, being older, is associated with higher degrees of serpentinization and sediment cover, which introduce more volatiles inducing more robust partial melting of the mantle wedge.
The isl2a transcription factor regulates pituitary development in zebrafish
Authors: Yan Chen-Yan , Wu Feng-Yao , Sun Feng , Fang Ya , Zhang Rui-Jia , Zhang Chang-Run , Zhang Cao-Xu , Wang Zheng , Yang Rui-Meng , Yang Liu , Dong Mei , Zhang Qian-Yue , Ye Xiao-Ping , Song Huai-Dong , Zhao Shuang-Xia 
Published: February 2023

BackgroundISL LIM homeobox 2, also known as insulin gene enhancer protein ISL-2 (ISL2), is a transcription factor gene that participates in a wide range of developmental events. However, the role of ISL2 in the hypothalamus-pituitary-thyroid axis is largely unknown. In the present study, we characterized the expression patterns of ISL2 and revealed its regulative role during embryogenesis using zebrafish.MethodsWe used the CRISPR/Cas9 system to successfully establish homozygous ISL2-orthologue (isl2a and isl2b) knockout zebrafish. Moreover, we utilized these knockout zebrafish to analyze the pituitary and thyroid phenotypes in vivo. For further molecular characterization, in situ hybridization and immunofluorescence were performed.ResultsThe isl2a mutant zebrafish presented with thyroid hypoplasia, reduced whole-body levels of thyroid hormones, increased early mortality, gender imbalance, and morphological retardation during maturity. Additionally, thyrotropes, a pituitary cell type, was notably decreased during development. Importantly, the transcriptional levels of pituitary-thyroid axis hormones-encoding genes, such as tshba, cga, and tg, were significantly decreased in isl2a mutants. Finally, the thyroid dysplasia in isl2a mutant larvae may be attributed to a reduction in proliferation rather than changes in apoptosis.ConclusionsIn summary, isl2a regulates the transcriptional levels of marker genes in hypothalamus-pituitary-thyroid axis, and isl2a knockout causing low thyroid hormone levels in zebrafish. Thus, isl2a identified by the present study, is a novel regulator for pituitary cell differentiation in zebrafish, resulting in thyroid gland hypoplasia and phenotypes of hypothyroidism.