bluuebunny/crossref_metadata_2025_split huggingface dataset:
Wet compaction to a blue nugget: a critical phase in galaxy evolution
Authors: Lapiner Sharon , Dekel Avishai , Freundlich Jonathan , Ginzburg Omri , Jiang Fangzhou , Kretschmer Michael , Tacchella Sandro , Ceverino Daniel , Primack Joel 
Published: April 2023

ABSTRACT
We utilize high-resolution cosmological simulations to reveal that high-redshift galaxies tend to undergo a robust ‘wet compaction’ event when near a ‘golden’ stellar mass of $\sim \!\!10^{10}\, \rm M_\odot$ . This is a gaseous shrinkage to a compact star-forming phase, a ‘blue nugget’ (BN), followed by central quenching of star formation to a compact passive stellar bulge, a ‘red nugget’ (RN), and a buildup of an extended gaseous disc and ring. Such nuggets are observed at cosmic noon and seed today’s early-type galaxies. The compaction is triggered by a drastic loss of angular momentum due to, e.g. wet mergers, counter-rotating cold streams, or violent disc instability. The BN phase marks drastic transitions in the galaxy structural, compositional, and kinematic properties. The transitions are from star forming to quenched inside-out, from diffuse to compact with an extended disc or ring and a stellar envelope, from dark matter to baryon central dominance, from prolate to oblate stellar shape, from pressure to rotation support, from low to high metallicity, and from supernova to AGN feedback. The central black hole growth, first suppressed by supernova feedback when below the golden mass, is boosted by the compaction, and the black hole keeps growing once the halo is massive enough to lock in the supernova ejecta.
Orientation of the spins of galaxies in the local volume
Authors: Karachentsev I D , Zozulia V D 
Published: April 2023

ABSTRACT
We estimated the angular momentum, J, of 720 galaxies in the Local Volume with distances r &lt; 12 Mpc. The distribution of the average angular momentum along the Hubble sequence has a maximum at the morphological type T = 4 (Sbc), while the dispersion of the J-values for galaxies is minimal. Among the Local Volume population, 27 elite spiral galaxies stand out, with an angular momentum &gt; 0.15 of the Milky Way, J &gt; 0.15JMW, making the main contribution ($\gt 90~{{\ \rm per\ cent}}$ ) to the total angular momentum of galaxies in the considered volume. Using observational data on the kinematics and structure of these galaxies, we determined the direction of their spins. We present the first map of the distribution of the spins of 27 nearby massive spiral galaxies in the sky and note that their pattern does not exhibit significant alignment with respect to the Local Sheet plane. The relationship between the magnitude of the angular momentum and stellar mass of the local galaxies is well represented by a power law with an exponent of (5/3) over an interval of six orders of magnitude of the mass of galaxies.
Micro Germline-Restricted Chromosome in Blue Tits: Evidence for Meiotic Functions
Authors: Mueller Jakob C , Schlebusch Stephen A , Pei Yifan , Poignet Manon , Vontzou Niki , Ruiz-Ruano Francisco J , Albrecht Tomáš , Reifová Radka , Forstmeier Wolfgang , Suh Alexander , Kempenaers Bart 
Published: April 2023

Abstract
The germline-restricted chromosome (GRC) is likely present in all songbird species but differs widely in size and gene content. This extra chromosome has been described as either a microchromosome with only limited basic gene content or a macrochromosome with enriched gene functions related to female gonad and embryo development. Here, we assembled, annotated, and characterized the first micro-GRC in the blue tit (Cyanistes caeruleus) using high-fidelity long-read sequencing data. Although some genes on the blue tit GRC show signals of pseudogenization, others potentially have important functions, either currently or in the past. We highlight the GRC gene paralog BMP15, which is among the highest expressed GRC genes both in blue tits and in zebra finches (Taeniopygia guttata) and is known to play a role in oocyte and follicular maturation in other vertebrates. The GRC genes of the blue tit are further enriched for functions related to the synaptonemal complex. We found a similar functional enrichment when analyzing published data on GRC genes from two nightingale species (Luscinia spp.). We hypothesize that these genes play a role in maintaining standard maternal inheritance or in recombining maternal and paternal GRCs during potential episodes of biparental inheritance.
OrthoVenn3: an integrated platform for exploring and visualizing orthologous data across genomes
Authors: Sun Jiahe , Lu Fang , Luo Yongjiang , Bie Lingzi , Xu Ling , Wang Yi 
Published: April 2023

Abstract
Advancements in comparative genomics research have led to a growing interest in studying species evolution and genetic diversity. To facilitate this research, OrthoVenn3 has been developed as a powerful, web-based tool that enables users to efficiently identify and annotate orthologous clusters and infer phylogenetic relationships across a range of species. The latest upgrade of OrthoVenn includes several important new features, including enhanced orthologous cluster identification accuracy, improved visualization capabilities for numerous sets of data, and wrapped phylogenetic analysis. Furthermore, OrthoVenn3 now provides gene family contraction and expansion analysis to support researchers better understanding the evolutionary history of gene families, as well as collinearity analysis to detect conserved and variable genomic structures. With its intuitive user interface and robust functionality, OrthoVenn3 is a valuable resource for comparative genomics research. The tool is freely accessible at https://orthovenn3.bioinfotoolkits.net.
Cytoplasmic aggregation of mutant FUS causes multistep RNA splicing perturbations in the course of motor neuron pathology
Authors: Rezvykh Alexander P , Ustyugov Aleksey A , Chaprov Kirill D , Teterina Ekaterina V , Nebogatikov Vladimir O , Spasskaya Daria S , Evgen’ev Michael B , Morozov Alexey V , Funikov Sergei Yu 
Published: April 2023

AbstractDysfunction of the RNA-binding protein (RBP) FUS implicated in RNA metabolism can cause amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases. Mutations affecting FUS nuclear localization can drive RNA splicing defects and stimulate the formation of non-amyloid inclusions in affected neurons. However, the mechanism by which FUS mutations contribute to the development of ALS remains uncertain. Here we describe a pattern of RNA splicing changes in the dynamics of the continuous proteinopathy induced by mislocalized FUS. We show that the decrease in intron retention of FUS-associated transcripts represents the hallmark of the pathogenesis of ALS and is the earliest molecular event in the course of progression of the disease. As FUS aggregation increases, the pattern of RNA splicing changes, becoming more complex, including a decrease in the inclusion of neuron-specific microexons and induction of cryptic exon splicing due to the sequestration of additional RBPs into FUS aggregates. Crucially, the identified features of the pathological splicing pattern are also observed in ALS patients in both sporadic and familial cases. Our data provide evidence that both a loss of nuclear FUS function due to mislocalization and the subsequent cytoplasmic aggregation of mutant protein lead to the disruption of RNA splicing in a multistep fashion during FUS aggregation.
Kidney and urinary tract involvement in systemic mastocytosis
Authors: Bharati Joyita , Shah Nikita , Desai Ankuri , Gladstone Douglas , Krushna Das Chandan , Nieto Maria Jacqueline , Jhaveri Kenar D , Izzedine Hassan 
Published: April 2023

ABSTRACT
Systemic mastocytosis (SM) is a disorder of excessive mast cell accumulation in tissues due to a somatic gain-of-function mutation, commonly in the KIT gene, which prevents apoptosis of mast cells. Whereas bone marrow, skin, lymph nodes, spleen and gastrointestinal tract are commonly involved, kidneys are rarely involved directly by SM. However, there are increasing reports of indirect kidney involvement in patients with SM. Novel anti-neoplastic agents to treat advanced forms of SM include non-specific tyrosine kinase inhibitors, which are reported to be associated with kidney dysfunction in some patients. SM is also associated with immune-mediated glomerulonephritis (GN) such as mesangioproliferative GN, membranous nephropathy and diffuse proliferative GN. Kidney injury, in the form of monoclonal deposition disease and primary light chain amyloidosis, is reported in SM associated with plasma cell dyscrasia. In this narrative review we discuss the various ways kidneys (and the urinary tract) are involved in patients with SM.
Cosmological gravity probes: Connecting recent theoretical developments to forthcoming observations
Authors: Arai Shun , Aoki Katsuki , Chinone Yuji , Kimura Rampei , Kobayashi Tsutomu , Miyatake Hironao , Yamauchi Daisuke , Yokoyama Shuichiro , Akitsu Kazuyuki , Hiramatsu Takashi , Hirano Shin’ichi , Kase Ryotaro , Katsuragawa Taishi , Kobayashi Yosuke , Namikawa Toshiya , Nishimichi Takahiro , Okumura Teppei , Shiraishi Maresuke , Shirasaki Masato , Sunayama Tomomi , Takahashi Kazufumi , Taruya Atsushi , Tokuda Junsei 
Published: April 2023

Abstract
Since the discovery of the accelerated expansion of the present universe, significant theoretical developments have been made in the area of modified gravity. In the meantime, cosmological observations have been providing more high-quality data, allowing us to explore gravity on cosmological scales. To bridge the recent theoretical developments and observations, we present an overview of a variety of modified theories of gravity and the cosmological observables in the cosmic microwave background and large-scale structure, supplemented with a summary of predictions for cosmological observables derived from cosmological perturbations and sophisticated numerical studies. We specifically consider scalar–tensor theories in the Horndeski and DHOST family, massive gravity/bigravity, vector–tensor theories, metric-affine gravity, and cuscuton/minimally modified gravity, and discuss the current status of those theories with emphasis on their physical motivations, validity, appealing features, the level of maturity, and calculability. We conclude that the Horndeski theory is one of the most well-developed theories of modified gravity, although several remaining issues are left for future observations. The paper aims to help to develop strategies for testing gravity with ongoing and forthcoming cosmological observations.
Quantum mechanical calculations of synchro-curvature radiations: maser possibility
Authors: Tomoda Hiroko , Yamada Shoichi 
Published: April 2023

Abstract
We calculate the radiative transition rates for synchro-curvature radiation to explore the possibility of maser in the environment that may occur in the magnetosphere of neutron stars (NSs). Unlike previous studies, we employ relativistic quantum mechanics, solving the Dirac equation for an electron in helical magnetic fields. Following Voisin et al. [1,2], we utilize adiabatic spinor rotations, under the assumption that the curvature of magnetic-field lines is much larger than the Larmor radius, to obtain the wave functions of an electron. We classify the electron states either by the spin operator projected on the magnetic field or by the helicity operator. To demonstrate that there is a regime where the true absorption rate becomes negative, we numerically evaluate the obtained formulae for some parameter values that may be encountered in the outer gaps of different types of NSs. We show that there is indeed a range of parameters for the negative true absorption rate to occur. We will also study the dependence on those parameters systematically and discuss the classical limit of our formulae. We finally give a crude estimate of the amplification factor in the same environment.
Dress code for infrared safe scattering in QED
Authors: Hirai Hayato , Sugishita Sotaro 
Published: April 2023

Abstract
We study the S-matrix and inclusive cross-section for general dressed states in quantum electrodynamics. We obtain an infrared factorization formula of the S-matrix elements for general dressed states. This enables us to study which dressed states lead to infrared-safe S-matrix elements. The condition for dressed states can be interpreted as the memory effect, which is nothing but the conservation law of the asymptotic symmetry. We derive the generalized soft photon theorem for general dressed states. We also compute an inclusive cross-section using general dressed states. It is necessary to use appropriate initial and final dressed states to evaluate interference effects, which cannot be computed correctly by using Fock states due to the infrared divergence.
Codelivery of dihydroartemisinin and chlorin e6 by copolymer nanoparticles enables boosting photodynamic therapy of breast cancer with low-power irradiation
Authors: Jia Jing , Chen Wenping , Xu Long , Wang Xuewen , Li Min , Wang Bin , Huang Xiangyu , Wang Tao , Chen Yang , Li Mengdie , Tian Dan , Zhuang Junyang , Lin Xinhua , Li Ning 
Published: April 2023

Abstract
Given that chemotherapy as a stand-alone therapeutic strategy may not be sufficient to effectively treat cancer, there is increasing interest in combination of chemotherapy and alternative therapies. Photodynamic therapy has the advantages of high selectivity and low side effects, so the combination of photodynamic therapy and chemotherapy has become one of the most appealing strategies for tumor treatment. In this work, we constructed a nano drug codelivery system (PPDC) to realize the combined treatment of chemotherapy and photodynamic therapy through encapsulating chemotherapeutic drug dihydroartemisinin and photosensitizer chlorin e6 in PEG-PCL. The potentials, particle size and morphology of nanoparticles were characterized by dynamic light scattering and transmission electron microscopy. We also investigated the reactive oxygen species (ROS) generation and drug release ability. The antitumor effect in vitro was investigated by methylthiazolyldiphenyl-tetrazolium bromide assays and cell apoptosis experiments, and the potential cell death mechanisms were explored by ROS detection and Western blot analysis. The in vivo antitumor effect of PPDC was evaluated under the guidance of fluorescence imaging. Our work provides a potential antitumor treatment approach and expands the application of dihydroartemisinin for breast cancer therapy.
The Direct and Long-Term Effects of Raloxifene as Adjunctive Treatment for Schizophrenia-Spectrum Disorders: A Double-Blind, Randomized Clinical Trial
Authors: Brand Bodyl A , de Boer Janna N , Marcelis Machteld C , Grootens Koen P , Luykx Jurjen J , Sommer Iris E 
Published: April 2023

Abstract

Background and hypothesis
Several studies suggest that raloxifene, a selective estrogen receptor modulator, improves symptoms and cognition in post-menopausal women with Schizophrenia-Spectrum Disorders (SSD). We aimed to assess the effects of adjunctive raloxifene in women and men with SSD.

Study design
This parallel, randomized, double-blind, placebo-controlled trial included adult SSD patients across the Netherlands and Belgium. Participants were stratified by age, sex, and global functioning and randomly assigned 1:1 to 12-week add-on raloxifene or placebo. Primary outcomes were symptom severity at 6, 12, and 38 weeks and cognition at 12 and 38 weeks, as measured with the Positive and Negative Syndrome Scale and the Brief Assessment of Cognition in Schizophrenia, respectively. Intention-to-treat analyses were performed using linear mixed-effect models.

Study results
We assessed 261 patients for eligibility, of which 102 (28% female) were assigned to raloxifene (n = 52) or placebo (n = 48). Although we found no main effect of raloxifene, secondary sex-specific analysis showed that in women, raloxifene had beneficial effects on negative symptoms at week 6 (LSM −2.92; adjusted P = 0.020) and week 12 (LSM −3.12; adjusted P = 0.030), and on working memory at week 38 (LSM 0.73; adjusted P = 0.040), while having negative effects on working memory at week 38 in men (LSM −0.53; adjusted P = 0.026). The number of adverse events was similar between groups.

Conclusions
Our results do not support the use of raloxifene in patients with SSD in general, but suggest female-specific beneficial effects of raloxifene on negative symptoms and working memory. Our findings encourage further research on sex-specific pharmacotherapeutic treatment.
Complexities and Nuances in Radical Right Voters’ (Anti)Feminism
Authors: Off Gefjon 
Published: April 2023

Abstract
While radical right parties commonly advance conservative gender positions, research on radical right voters’ gender attitudes remains inconclusive. To understand radical right voters’ gender attitudes, I first analyze previous research for frames that antifeminist actors commonly use to advance their arguments. I then draw on interviews with eastern German radical right voters to analyze whether and how these voters apply antifeminist frames to argue about feminist policy. I demonstrate that they use antifeminist frames to oppose mostly third-wave and recently salient feminist issues, but also support certain feminist policies, sometimes for instrumental reasons. Further, voters include particularities of their context in their arguments. Eastern Germany constitutes an atypical context, allowing for insights into voters’ (anti)feminism in a post-socialist context marked by atheism and relatively advanced gender norms. The study contributes to understanding complexities and nuances in radical right voters’ gender attitudes, and thereby to understanding cultural grievances beyond anti-immigration attitudes.
Polystyrene nanoplastics exacerbated Pb-induced liver toxicity in mice
Authors: Yuan Hongbin , Wen Siyue , Zhao Yu , Hu Liehai , Xu Hengyi 
Published: April 2023

AbstractNanoplastics are widely distributed in the environment and can adsorb heavy metals, which poses a potential threat to human health through food chain. It is necessary to assess the combined toxicity of nanoplastics and heavy metals. The adverse effect of Pb and nanoplastics on liver, single or in combination, was evaluated in this study. The results showed that the Pb content in co-exposure group of nanoplastics and Pb (PN group) was higher than the group exposed to Pb alone (Pb group). And more severe inflammatory infiltration was observed in liver sections of PN group. The level of inflammatory cytokines and malondialdehyde were increased, while the superoxide dismutase activity was decreased in liver tissues of PN group. Moreover, the gene expression level of nuclear factor-erythroid 2-related factor 2, nicotinamide adenine dinucleotide phosphate:quinine oxidoreductase 1 and catalase, which is related to antioxidation, was downregulated. And the expression level of cleaved-Caspase9 and cleaved-Caspase3 were increased. However, with the supplementation of oxidative stress inhibitor N-Acetyl-L-cysteine, liver damage shown in PN group was evidently alleviated. In summary, nanoplastics evidently exacerbated the deposition of Pb in liver and potentially aggravated the Pb-induced liver toxicity by activating oxidative stress.
Fetal and neonatal dioxin exposure causes sex-specific metabolic alterations in mice
Authors: Hoyeck Myriam P , Merhi Rayanna C , Tulloch Cameron , McCormick Kaitlyn , Mohammed Abu Hossain Shahen , Hanson Antonio A , Bruin Jennifer E 
Published: April 2023

Abstract
Epidemiological studies report associations between early-life exposure to persistent organic pollutants (POPs) and impaired metabolic homeostasis in adulthood. We investigated the impact of early-life exposure to low-dose 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD or ‘dioxin’) on the establishment of β-cell area during the perinatal period, as well as β-cell health and glucose homeostasis later in life. Adult female mice were injected with either corn oil (CO; vehicle control) or TCDD (20 ng/kg/day) 2×/week throughout mating, pregnancy, and lactation; offspring were thus indirectly exposed to maternal TCDD in utero and during lactation, with pollutant exposure ending at weaning. All offspring were maintained on chow diet from weaning until 12–17 weeks of age, after which a subset of CO- and TCDD-exposed offspring were transferred to a 45% high fat diet (HFD) as a metabolic stressor for an additional 10 weeks. TCDD significantly upregulated cytochrome P450 1a1 (Cyp1a1) gene expression in offspring pancreas at birth and weaning, indicating that maternal TCDD directly reaches the developing pancreas. TCDD-exposed pups were transiently hypoglycemic at birth and females were born with reduced % β-cell area, which persisted into adulthood. Early-life TCDD exposure had no persistent long-term effects on glucose homeostasis in chow-fed offspring, but when transferred to HFD, TCDD-exposed female offspring had a delayed onset of HFD-induced hyperglycemia, more pronounced HFD-induced hyperinsulinemia, and increase % PCNA+ β-cells compared with CO-exposed female offspring. This study demonstrates that early-life exposure of mice to TCDD has modest effects on metabolic health in chow-fed offspring but alters metabolic adaptability to HFD feeding in females.
Efficacy and Safety of Picosecond Laser in the Treatment of Melasma: A Network Meta-analysis
Authors: Ren Rongxin , Bao Shiwei , Qian Wenjiang , Zhao Hongyi 
Published: April 2023

BACKGROUND
The role of lasers in the treatment of melasma and acquired hyperpigmentation disease of the skin has been suggested by clinicians. However, there is no consensus on the most efficient and safe treatment method.

OBJECTIVE
To systematically evaluate the efficacy and safety of picosecond laser in the treatment of melasma.

METHODS and Materials
PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure, Chinese scientific journal database, and Wanfang database were searched. The data for therapeutic efficacy, melasma area and severity score, and incidence rate of adverse reactions were extracted from the included studies.

RESULTS
A total of 20 studies involving 1,182 patients were included in this network meta-analysis. Combined therapy with carbamic acid and 1064-nm picosecond laser was the best measure. Melasma area and severity index score of patients after low-power fractional CO2 laser treatment was higher than that of patients after the treatment with 1064-nm picosecond laser.

CONCLUSION
Aminomethyl cyclic acid combined with 1064-nm picosecond laser may have the highest effective rate after treatment. Low-power fractional CO2 laser provided the lowest melasma area and severity index score after treatment, and the incidence rate of adverse reactions after treatment, was highest when intense pulsed light was used.