bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antithrombotic drugs for cardiovascular risk reduction in patients with lower limb peripheral arterial disease: protocol for a systematic review and network meta-analysis of randomised controlled trials
Authors: Sidebottom David Brooke , Huang Chao , Carradice Daniel , Holt Peter J , John-Pierre Karen , Roy Iain Nicholas 
Published: August 2023

IntroductionThe optimal antithrombotic regimen to reduce the risk of vascular events in patients with peripheral arterial disease (PAD) is contentious. This systematic review and network meta-analysis (NMA) aims to define the relative efficacy and risks of previously investigated antithrombotic medication regimens in preventing major cardiovascular events, vascular limb events and mortality in patients with PAD.Methods and analysisA peer-reviewed, systematic search will be executed in English on Medline, Embase, Cochrane (CENTRAL), Web of Science and Google Scholar databases in late 2022. The WHO International Clinical Trials Registry platform will also be searched for ongoing trials. Abstracts will be screened independently by two researchers for randomised controlled trials meeting the review criteria. All associated publications including the study protocol will be sought and evaluated together against prespecified inclusion/exclusion criteria. Two researchers will extract the data into a prepiloted extraction form. Risk-of-bias assessments will be performed using the Cochrane ‘Risk-of-Bias V.2’ criteria by individuals with domain expertise. All differences will be resolved by consensus or a third individual for ties.Included trials will be summarised. An NMA will be performed, subject to checks of assumptions. Both primary and secondary outcomes will be analysed on a whole network basis. Pairwise comparisons and league tables will be produced. Prespecified subgroup analyses will include sex, ethnicity, disease status, conservative versus interventional management and key comorbidities. The findings will be evaluated using the Grading of Recommendation Assessment, Development and Evaluation, informed by patient and public involvement work.Ethics and disseminationThis is a systematic review of data in the public domain and does not require ethical approval. Dissemination will include presentations to key vascular and patient organisations, publication in a peer-reviewed journal and an open-access repository of the study data.PROSPERO registration numberCRD42023389262.
Dedicated service for Barrett’s oesophagus surveillance endoscopy yields higher dysplasia detection and guideline adherence in a non-tertiary setting in the UK: a 5-year comparative cohort study
Authors: Ratcliffe Elizabeth , Britton James , Yalamanchili Harika , Rostami Izabela , Nadir Syed Mujtaba Hasnain , Korani Mohamed , Eruchie Ikedichukwu , Wazirdin Muhammad Awais , Prasad Neeraj , Hamdy Shaheen , McLaughlin John , Ang Yeng 
Published: August 2023

ObjectiveBarrett’s oesophagus (BO) endoscopic surveillance is performed to varying quality, dedicated services may offer improved outcomes. This study compares a dedicated BO service to standard care, specifically dysplasia detection rate (DDR), guideline adherence and use of advanced imaging modalities in a non-tertiary setting.Design/method5-year retrospective comparative cohort study comparing a dedicated BO endoscopy service with surveillance performed on non-dedicated slots at a non-tertiary centre in the UK. All adult patients undergoing BO surveillance between 1 March 2016 and 1 March 2021 were reviewed and those who underwent endoscopy on a dedicated BO service run by endoscopists with training in BO was compared with patients receiving their BO surveillance on any other endoscopy list. Endoscopy reports, histology results and clinic letters were reviewed for DDR and British society of gastroenterology guideline adherence.Results921 BO procedures were included (678 patients). 574 (62%) endoscopies were on a dedicated BO list vs 348 (38%) on non-dedicated.DDR was significantly higher in the dedicated cohort 6.3% (36/568) vs 2.7% (9/337) (p=0.014). Significance was sustained when cases with indefinite for dysplasia were excluded: 4.9% 27/533 vs 0.9% 3/329 (p=0.002). Guideline adherence was significantly better on the dedicated endoscopy lists.Factors associated with dysplasia detection in regression analysis included visible lesion documentation (p=0.036), use of targeted biopsies (p=<0.001), number of biopsies obtained (p≤0.001).ConclusionsA dedicated Barrett’s service showed higher DDR and guideline adherence than standard care and may be beneficial pending randomised trial data.
Clinical and subclinical microemboli following neuroangiography in children
Authors: Alghamdi Ibrahim , Dmytriw Adam A , Amirabadi Afsaneh , Lebarron Samantha , Rea Vanessa , Parra-Fariñas Carmen , Muthusami Prakash 
Published: August 2023

BackgroundTo assess the frequency, imaging appearances, and risk factors of brain microemboli following pediatric neuroangiography, as assessed by early diffusion-weighted MRI imaging (DWI).MethodsThis single-center, retrospective analysis investigated early DWI post-pediatric neuroangiography. Patients aged 0–18 years who had diagnostic neuroangiography and DWI within a week postprocedure were included. Data on clinical and procedural parameters and MRI findings were recorded. Univariate and multivariate analyses were performed on the following risk factors: age, weight, vasculopathy, antiplatelet drug use, access type, intraprocedural heparin, procedure duration, neck arteries catheterized, and angiographic runs. A p-value<0.05 indicated statistical significance.ResultsEighty-two children were included (40.2% female), mean age 10.1±4.5 years (range: 7 months–17 years). There were no intraprocedural thromboembolic complications recognized. DWI positivity was seen following 3.6% (3/82) procedures: two with transient symptoms, and one instance of silent microemboli. There were no territorial infarcts or clinical stroke. Children with underlying vasculopathy had a higher risk of microemboli from angiography than children without vasculopathy (OR 31.6, p=0.02), and the OR of microemboli following transradial angiography was 79.1 (p=0.005) as compared with transfemoral angiography. Univariate and multivariate analysis showed a significant association between microemboli and number of angiographic runs (p=0.004). Follow-up MRI in all three patients showed no residual abnormal signal.ConclusionsCerebral microemboli are unusual following uncomplicated neuroangiography in children. However, in the presence of underlying vasculopathy and with transradial technique, the incidence approaches that reported in the adult literature. An increased association with the number of angiographic runs is an important and controllable factor.
Majorana bound states in a driven quantum dot
Authors: Medina-Cuy Fabián , Martínez Dunkan , Domínguez-Adame Francisco , Orellana P. A. 
Published: August 2023

AbstractWe study a periodically driven quantum dot in two different configurations. In the first setup, a quantum dot coupled to a topological superconductor and a normal metal lead. In the second setup, a T-shape quantum dot connected to two topological superconductors and side coupled to a normal metal lead. By a combination of non-equilibrium Green’s function techniques and Floquet’s formalism, we obtain the quasienergy spectra as a function of the amplitude, frequency, and superconducting phase difference. We show that the states develop unique electronic responses, such as the broken particle-hole symmetry that appears when considering the non-locality of Majorana bound states. Finally, we compute the time-average current and the differential conductance to reveal these spectra signatures through physically measurable magnitudes in the two proposed configurations.
Supplementary Table 1 from Phase II Window Study of Olaparib Alone or with Cisplatin or Durvalumab in Operable Head and Neck Cancer
Authors: Moutafi Myrto , Koliou Georgia-Angeliki , Papaxoinis George , Economopoulou Panagiota , Kotsantis Ioannis , Gkotzamanidou Maria , Anastasiou Maria , Pectasides Dimitrios , Kyrodimos Efthymios , Delides Alexander , Giotakis Evangelos , Papadimitriou Nikolaos G. , Panayiotides Ioannis G. , Perisanidis Christos , Fernandez Aileen I. , Xirou Vasiliki , Poulios Christos , Gagari Eleni , Yaghoobi Vesal , Gavrielatou Niki , Shafi Saba , Aung Thazin Nwe , Kougioumtzopoulou Andromachi , Kouloulias Vassilis , Palialexis Konstantinos , Gkolfinopoulos Stavros , Strati Areti , Lianidou Evi , Fountzilas George , Rimm David L. , Foukas Periklis G. , Psyrri Amanda 
Published: August 2023

<p>Supplementary Table 1a. Representativeness of Study Participants Supplementary</p><p>Table 1b. Nanostring IO360 panel</p>
Arterial Age and Early Vascular Aging, But Not Chronological Age, Are Associated With Faster Thoracic Aortic Aneurysm Growth
Authors: Mian Owais , Santi Nicolas , Boodhwani Munir , Beauchesne Luc , Chan Kwan‐Leung , Dennie Carole , Wells George A. , Coutinho Thais 
Published: August 2023

Background
Aneurysm size is an imperfect risk assessment tool for those with thoracic aortic aneurysm (TAA). Assessing arterial age may help TAA risk stratification, as it better reflects aortic health. We sought to evaluate arterial age as a predictor of faster TAA growth, independently of chronological age.

Methods and Results

We examined 137 patients with TAA. Arterial age was estimated according to validated equations, using patients' blood pressure and carotid‐femoral pulse wave velocity. Aneurysm growth was determined prospectively from available imaging studies. Multivariable linear regression assessed the association of chronological age and arterial age with TAA growth, and multivariable logistic regression assessed associations of chronological and arterial age with the presence of accelerated aneurysm growth (defined as growth>median in the sample). Mean±SD chronological and arterial ages were 62.2±11.3 and 54.2±24.5 years, respectively. Mean baseline TAA size and follow‐up time were 45.9±4.0 mm and 4.5±1.9 years, respectively. Median (interquartile range) TAA growth was 0.31 (0.14–0.52) mm/year. Older arterial age (ß±SE for 1 year: 0.004±0.001,
P
<0.0001) was independently associated with faster TAA growth, while chronological age was not (
P
=0.083). In logistic regression, each 5‐year increase in arterial age was associated with a 23% increase in the odds of accelerated TAA growth (95% CI, 1.085–1.394;
P
=0.001).

Conclusions
Arterial age is independently associated with accelerated aneurysm expansion, while chronological age is not. Our results highlight that a noninvasive and inexpensive assessment of arterial age can potentially be useful for TAA risk stratification and disease monitoring as compared with the current clinical standard (chronological age).
Progranulin Maintains Blood Pressure and Vascular Tone Dependent on EphrinA2 and Sortilin1 Receptors and Endothelial Nitric Oxide Synthase Activation
Authors: Bruder‐Nascimento Ariane , Awata Wanessa M. C. , Alves Juliano V. , Singh Shubhnita , Costa Rafael M. , Bruder‐Nascimento Thiago 
Published: August 2023

Background
The mechanisms determining vascular tone are still not completely understood, even though it is a significant factor in blood pressure management. Many circulating proteins have a significant impact on controlling vascular tone. Progranulin displays anti‐inflammatory effects and has been extensively studied in neurodegenerative illnesses. We investigated whether progranulin sustains the vascular tone that helps regulate blood pressure.

Methods and Results

We used male and female C57BL6/J wild type (progranulin
+/+
) and B6(Cg)‐Grn
tm1.1Aidi
/J (progranulin
−/−
) to understand the impact of progranulin on vascular contractility and blood pressure. We found that progranulin
−/−
mice display elevated blood pressure followed by hypercontractility to noradrenaline in mesenteric arteries, which is restored by supplementing the mice with recombinant progranulin. In ex vivo experiments, recombinant progranulin attenuated the vascular contractility to noradrenaline in male and female progranulin
+/+
arteries, which was blunted by blocking EphrinA2 or Sortilin1. To understand the mechanisms whereby progranulin evokes anticontractile effects, we inhibited endothelial factors. N(gamma)‐nitro‐L‐arginine methyl ester (nitric oxide synthase inhibitor) prevented the progranulin effects, whereas indomethacin (cyclooxygenase inhibitor) affected only the contractility in arteries incubated with vehicle, indicating that progranulin increases nitric oxide and decreases contractile prostanoids. Finally, recombinant progranulin induced endothelial nitric oxide synthase phosphorylation and nitric oxide production in isolated mesenteric endothelial cells.

Conclusions
Circulating progranulin regulates vascular tone and blood pressure via EphrinA2 and Sortilin1 receptors and endothelial nitric oxide synthase activation. Collectively, our data suggest that deficiency in progranulin is a cardiovascular risk factor and that progranulin might be a new therapeutic avenue to treat high blood pressure.
Sodium‐Glucose Cotransporter‐2 Inhibitors and Primary Prevention of Atherosclerotic Cardiovascular Disease: A Meta‐Analysis of Randomized Trials and Systematic Review
Authors: Rahman Hammad , Khan Safi U. , Lone Ahmad N. , Ghosh Priyanka , Kunduru Mahathi , Sharma Saurabh , Sattur Sudhakar , Kaluski Edo 
Published: August 2023

Background
Sodium‐glucose cotransporter‐2 (SGLT2) inhibitors reduce atherosclerotic cardiovascular disease (ASCVD) events in patients with prior ASCVD and type 2 diabetes; however, this benefit is uncertain in patients without established ASCVD.

Methods and Results

Large‐scale cardiovascular outcome randomized controlled trials or their prespecified subgroup analyses were selected, evaluating SGLT2 inhibitors versus placebo for primary prevention of ASCVD (inception, March 2023). The primary outcome was atherosclerotic major adverse cardiovascular events (MACEs), which was a composite of cardiovascular mortality, myocardial infarction, and stroke. The secondary outcomes were individual components of MACEs and all‐cause mortality. The outcomes were reported as random‐effect relative risk (RR) with a 95% CI. This analysis, comprising 23 987 patients enrolled in 5 randomized controlled trials with a mean follow‐up duration of ≈135 weeks, found no significant reduction in atherosclerotic MACEs with SGLT2 inhibitors in comparison to placebo (RR, 0.85 [95% CI, 0.71–1.01];
P
=0.07; I
2
=44). There were no significant differences in cardiovascular mortality (RR, 0.93 [95% CI, 0.77–1.14];
P
=0.50; I
2
=0), myocardial infarction (RR, 0.88 [95% CI, 0.69–1.11];
P
=0.28; I
2
=23), and stroke (RR, 0.84 [95% CI, 0.62–1.16];
P
=0.29; I
2
=46). SGLT2 inhibitors significantly improved all‐cause mortality (RR, 0.85 [95% CI, 0.72–1.0];
P
=0.04; I
2
=23). On subgroup analyses, the use of SGLT2 inhibitors led to significant reductions in MACEs (RR, 0.74 [95% CI, 0.61–0.89];
P
=0.001), myocardial infarction (RR, 0.67 [95% CI, 0.47–0.97];
P
=0.03), and stroke (RR, 0.61 [95% CI, 0.41–0.91];
P
=0.01) primarily in patients with chronic kidney disease along with type 2 diabetes, whereas these benefits were not observed in patients with type 2 diabetes without chronic kidney disease.

Conclusions
SGLT2 inhibitors significantly reduced atherosclerotic MACEs in subjects having both chronic kidney disease and type 2 diabetes without established ASCVD.
Die masoretische Akzentuation in den poetischen Büchern (ספרי אמ״ת)
Authors: Trompelt Kevin 
Published: August 2023

Abstract
This article describes how the Masoretic accents found in the poetic books of Psalms, Job, and Proverbs (ספרי אמ״ת) divide and structure the text. It provides a detailed description of the hierarchical structure of the Masoretic accents used in these books. It also discusses the law of continuous dichotomy, which constitutes an essential principle that underlies every division of the text by the Masoretic accents. In particular, this article highlights the specific characteristics of the Masoretic accentuation in the poetic books, compared with the other books of the Hebrew Bible (כ״א ספרים). Throughout the article, the Masoretic accents are revealed to be of great relevance for the Masoretic text, because they mark the syntactic structure of every verse. Therefore, the Masoretic accents deserve the full attention of modern scholars who seek to study the Masoretic text.
The Poor Man’s Ewe Lamb (2 Sam 12:1–4) in Intersectional, Interspecies Perspective
Authors: Millar Suzanna R. 
Published: August 2023

Abstract
Nathan tells David a story about a rich man who takes and kills a poor man’s lamb (2 Sam 12:1–4). This, it turns out, is figurative for David’s own deeds of killing Uriah the Hittite and taking his wife. The story and its application suggest the intersecting power dynamics between groups: rich and poor, male and female, native and foreigner—and, crucially, human and nonhuman. This article argues that intersectional analysis should include an interspecies dimension, and explores these dynamics at work through various mechanisms of relation. Low status human groups are connected with nonhumans through animalisation, and are thereby delegitimised. Nonhuman animals and animalised humans are positioned as objects within mechanisms of domination, such as exploitation, exchange, and semiosis. The relationship between the poor man and lamb, though, offers another possibility: alliance. Care can be extended across species lines, with implications for intergroup relations throughout the intersectional web.
The Story of the Parici: Fiscal Transformation and Social Reconstruction in Ottoman Cyprus (1572–1672)
Authors: Demiryürek Mehmet 
Published: August 2023

Abstract
The Ottoman conquest (1570–71) changed the social, economic and cultural structure on Cyprus. It created a novel society consisting of Muslims and non-Muslims (zimmis or reaya), and led to a taxation system that reflected the evolution of the central administration’s financial needs. Based on Ottoman financial and judicial sources, this article examines an important element in early Ottoman Cypriot society, namely the parici of the Venetian era, known as barık (or parik, parikoz) during the first century of the Ottoman regime. In doing so, the article seeks to highlight one aspect of the fiscal transformation and reconstruction of society in Ottoman Cyprus.
The Indo-Iranian labial-extended causative suffix
Authors: Khoshsirat Zia , Byrd Andrew Miles 
Published: August 2023

Abstract
Alongside the expected reflexes of the Proto-Indo-European causative suffix *-éi̯e/o-, there appears in Indo-Iranian a second, expanded version that contains a labial consonant: Indic -(ā)páya- and Eastern Iranian (EIr.) *-(ā)u̯ai̯a-, the latter continued in Khotanese -ev-, Khwarazmian -(’)wy-, and other modern EIr. languages. In this paper, we will argue that *-(ā)u̯ai̯a- is also the source of a causative marker in two closely related Caspian (Western Iranian) languages, Gilaki and Tati-Talyshi, through a reconstructable Proto-Caspian form *-āwēn-. We propose that these three suffixes, -(ā)páya-, *-(ā)u̯ai̯a-, and *-āwēn-, originated in Proto-Indo-Iranian, through the rounding of a root-final laryngeal to a labial sound in causative formations.
Comprehensive analysis of CXCL14 uncovers its role during liver metastasis in colon cancer
Authors: Zhou Lei , Zhang Yan , Wei Ming , Du Kangming , Lin Jing , Wei Lihong 
Published: August 2023

Abstract
Background
The most common cause of death for colon cancer patients is liver metastasis.

Methods
All the data enrolled in this study were downloaded from two public databases, The Cancer Genome Atlas Program, the TCGA-COAD project and Gene Expression Omnibus, GSE41258 project. All the analysis was performed in R software.

Results
In our study, we systematically explored the molecules involved in the liver metastasis process of colon cancer. The biological role of these molecules was identified through the GO and KEGG analysis. Moreover, we identified that the molecules SERPINA3, SERPINA1, MMP3, ALDH1A3, PBK and CXCL14 were the independent factors for patients survival. The CXCL14 was selected for further analysis for its most significant P value. Single-cell analysis showed that the CXCL14 was mainly expressed in the fibroblasts. Meanwhile, the biological role of fibroblasts in the colon cancer microenvironment was investigated. Further, the clinical role of CXCL14 in colon cancer was also explored. The result showed that the CXCL14 is a protective factor against colon cancer independent of other clinical parameters like age, gender, clinical stage, and TNM classifications. Then, biological enrichment analysis indicated that the CXCL14 is predominantly involved in the activating of the WNT/β/catenin pathway, pancreas beta cells, peroxisome and bile acid metabolism. Immune infiltration analysis showed that for the patients with high CXCL14 levels, the plasma B cells, CD8 + T cells, neutrophil and NK cells might infiltrate more, in contrast to B cells, monocyte and macrophages. Furthermore, we found that the patients with low CXCL14 expression might be more sensitive to etoposide, rapamycin and sunitinib.

Conclusions
Our result could improve the understanding of the liver metastasis process in colon cancer. Also, CXCL14 was identified as an underlying therapeutic target for colon cancer.
Identification of co-expressed gene networks promoting CD8+ T cell infiltration and having prognostic value in uveal melanoma
Authors: Zhang Chun , Xiao Jing , Fa Luzhong , Jiang Fanwen , Jiang Hui , Zhou Lin , Xu Zhuping 
Published: August 2023

AbstractCurrent immunotherapies are unsatisfactory against uveal melanoma (UM); however, elevated CD8+ T cell infiltration level indicates poor prognosis in UM. Here, we aimed to identify co-expressed gene networks promoting CD8+ T cell infiltration in UM and created a prognostic hazard model based on the identified hub genes. Raw data and clinical information were downloaded from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. Stromal-immune comprehensive score (ESTIMATE) was used to evaluate the immune-infiltration landscape of the tumor microenvironment. Single-Sample Gene Set Enrichment Analysis (ssGSEA) and Weighted Correlation Network Analysis (WGCNA) were used to quantify CD8+ T cell infiltration level and identify hub genes. Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were performed to analyze the biological processes. Least absolute shrinkage and selection operator (LASSO) Cox regression were used to establish a prognostic model, which was further validated. Finally, pan-cancer analysis evaluated these genes to be associated with CD8+ T cell infiltration in other tumors. In conclusion, the proposed four-gene (PTPN12, IDH2, P2RX4, and KDELR2) prognostic hazard model had satisfactory prognostic ability. These hub genes may promote CD8+ T cell infiltration in UM through antigen presentation, and CD8+ T cell possibly function as Treg, resulting in poor prognosis. These findings might facilitate the development of novel immunotherapies.