bluuebunny/crossref_metadata_2025_split huggingface dataset:
Root elongation test on seeds of Sinapis alba reveals toxicity of extracts from thirteen colour forms of the Asian multi‐coloured ladybird, Harmonia axyridis
Authors: Sakaki Samane , Nedvěd Oldřich 
Published: January 2023

AbstractLadybirds (Coleoptera: Coccinellidae) use toxic compounds such as alkaloids in their hemolymph to defend against predators and pathogens. Direct measurement of their toxicity to predators is unavailable as predators show various avoidance reactions without eating the beetles. Because inhibition by harmonine – the alkaloid of the alien invasive ladybird Harmonia axyridis (Pallas) – was observed in many organisms, its toxicity can also be tested on various non‐target organisms. This is the first study examining ladybird alkaloid toxicity to plants. We used a quick, inexpensive, and easy‐to‐perform method to quantify the phytotoxicity of 13 strains of H. axyridis, representing natural colour forms and spontaneous laboratory mutations. We used the seed germination rate and root elongation of seedlings of Sinapis alba L. (Brassicaceae). Following a logistic curve, root length decreased with increasing concentration of the extract from adult beetles. The effect of extracts from the cowpea weevil, Callosobruchus maculatus (Fabricius) (Coleoptera: Chrysomelidae) (negative control) did not differ from the control (water). Extract from the lesser mealworm Alphitobius diaperinus (Panzer) (Coleoptera: Tenebrionidae) (positive control) decreased the root length to about half of that of the negative control. Extract from young ladybirds (1 week old) decreased the root length to about one‐third of the control and the extract from 3‐month‐old ladybirds to one‐10th. Differences in toxicity among all 13 strains were minor and not consistent for the two age cohorts.
Converting carbon dioxide to high value‐added products: Microalgae‐based green biomanufacturing
Authors: Sun Zhongliang , Chen Hui , Sun Liqin , Wang Qiang 
Published: January 2023

AbstractToday's world faces the dual pressure of carbon dioxide (CO2) emission reduction and an energy crisis. Microalgae, which can use solar energy to convert CO2 to organic matter, have emerged as a promising and renewable cell factory for producing nutrients, biofuels, and various high value‐added compounds (HVACs). They possess numerous advantages, such as high photosynthetic efficiency, fast growth rate, and use of agro‐industrial waste and nonagricultural land for cultivation. Microalgae can also effectively remove eutrophic elements (e.g., nitrogen and phosphorus) from wastewater and atmospheric pollutants (e.g., SOx and NOx) from flue gas, thus providing great environmental benefits. However, microalgae‐based production often faces low productivity, limiting applicability in industrial settings. Genetic and metabolic modifications of certain microalgal strains have proven effective in improving productivity. Here, we review the latest developments regarding the microalgae‐based production of platform compounds, biofuels, and other HVACs. Although still in the early exploration stage, the rapid development of gene editing tools, a deeper understanding of the metabolic pathways of microalgae and their regulatory mechanisms, and further optimization of cultivation procedures and photosynthetic efficiency can eventually enable the launch of microalgae‐based biomanufacturing for green industrial production. Therefore, this technology is strategically important for solving the current energy crisis problems of excessive CO2 emissions and environmental pollution. This review provides information about the advancement and development of microalgae‐based production over the past two decades and discusses possible future directions in the field.
The efficacy of bone reconstructive therapies in the management of peri‐implantitis. A systematic review and meta‐analysis
Authors: Donos Nikos , Calciolari Elena , Ghuman Mandeep , Baccini Michela , Sousa Vanessa , Nibali Luigi 
Published: January 2023

AbstractAimTo evaluate the efficacy of bone reconstructive procedures for the reduction of probing pocket depth (PPD), bleeding on probing (BOP), and suppuration in peri‐implantitis‐related bone defects at ≥12‐month follow‐up.Materials and MethodsThree databases were searched for randomized controlled trials (RCTs) and controlled clinical trials (CCTs) that compared bone reconstructive therapies to access flap surgery (AFS) (Focused Question—FQ 1), and RCTs, CCTs, and prospective case series that assessed the efficacy of reconstructive therapies (FQ 2). Meta‐analysis was performed for FQ1 when more than three studies were identified, while for FQ2 a network was drawn based on RCTs with common treatment arms.ResultsSeven RCTs were identified for FQ1 while five RCTs and six prospective case series for FQ2. There was no significant difference in PPD change between AFS and reconstructive surgery (−0.387; p = .325) at 12 months. Furthermore, no clear differences in terms of PPD and BOP changes resulted from the different reconstructive therapies included in the network. Only a small percentage of treated cases with any modality achieved peri‐implantitis resolution, as defined by different composite outcomes.ConclusionsReconstructive surgery does not offer significant improvements in peri‐implant clinical parameters as compared to AFS at 12 months. It was not possible to establish a hierarchy of efficacy among the different biomaterials employed for reconstructive surgery.
Scientometric analysis and literature synthesis of 60 years of science on the Atlantic goliath grouper (Epinephelus itajara)
Authors: Locatelli Anna C. P. , Bastos Rodrigo F. , Oliveira Matheus A. , Ferreira Beatrice P. 
Published: January 2023

AbstractHere, the authors investigate the evolution of scientific literature on the Atlantic goliath grouper (Epinephelus itajara), the largest grouper species in the Atlantic. This species was considered threatened according to the IUCN for nearly three decades due to overfishing and has been protected from fishing in a large part of its range. For the purpose of evaluating the scientific production on an endangered species banned from fishing, the authors present a scientometry and synthesis review analysing the literature produced in the timeline and the content of their studies. To this end, they set up an almost 60‐year literary database through the Scopus, Web of Science and Google Scholar platforms. They analyse the publication and knowledge area patterns over the time in the world and in Brazil. They also feature the main areas, locations, ecosystems and types of those research studies and briefly describe the main records found in each decade. An increase in the number of publications was observed from the 1990s onwards worldwide, and particularly in Brazil from the 2000s, coinciding with the pioneering legislations for species protection. Most of the studies were classified within ecology and conservation and took place in countries that implemented moratoriums and had extensive areas of mangroves. Thus, fishing moratorium, classification as endangered, mangroves distribution and conservation all play a role in the studies distribution and contribute positively to the knowledge, as well as support conservation strategies for the species and its ecosystems of occurrence.
Risk of colorectal cancer after appendectomy: A systematic review and meta‐analysis
Authors: Liu Zhuhui , Ma Xinyue , Zhu Chunqi , Fang Jing‐Yuan 
Published: January 2023

AbstractBackground and AimAppendectomy is associated with various diseases, but whether it increases the risk of colorectal cancer (CRC) remains uncertain. We conducted a systematic review and meta‐analysis aimed at investigating the suggested correlation between appendectomy and CRC.MethodsSystematic retrieval was performed using the PubMed, Embase, Cochrane library, Web of Science, and ClinicalTrials.gov databases up to May 4, 2022, for studies reported the influence of appendectomy on CRC, colon cancer (CC) or rectal cancer (RC). Odd ratios (ORs) and 95% confidence intervals (CIs) of CRC after appendectomy were pooled using the random effects model. Subgroup analyses were carried on by region, sex, and tumor location.ResultsOur search identified 1743 articles, of which 22 studies from three continents published between 1964 and 2022 were eligible for inclusion. Overall, people with appendectomy had a higher risk of CRC (OR = 1.31; 95% CI [1.05, 1.62]). But the risk for Europeans was not significant (OR = 0.94; 95% CI [0.87, 1.02]; I2 = 0%), while for Americans and Asians, appendectomy would increase the risk of CRC (OR = 1.68; 95% CI [1.15, 2.44]; I2 = 65% and OR = 1.46; 95% CI [1.04, 2.05]; I2 = 98%), especially in females and in developing countries. It is worth noting that appendectomy might be a protective factor for CC in European women (OR = 0.87; 95% CI [0.77, 0.98]; I2 = 0%).ConclusionsAppendectomy may be a risk factor for CRC, with varying degrees in different populations. More high‐quality cross‐regional studies are needed for better clinical decision making.
COVID‐19 hospitalization and mortality in community‐dwelling racially and ethnically diverse persons living with dementia
Authors: Thunell Johanna A. , Ferido Patricia , Zissimopoulos Julie M. 
Published: January 2023

AbstractBackgroundCommunity‐dwelling persons living with dementia (PLWD) are vulnerable to COVID‐19 infection, severity, and mortality due to the high prevalence of comorbidities, reliance on caregivers, and potential inability to employ risk reduction measures, among other factors.MethodsWe used a retrospective cohort of Medicare Fee‐For‐Service beneficiaries enrolled from January 2018 to September 2020 (n = 13,068,583), a comparison cohort from January 2019 to April 2021 (n = 13,250,297), and logistic regression to estimate the effect of dementia on COVID‐19 hospitalization and mortality in community‐dwelling older persons.ResultsCOVID‐19 diagnoses were higher among persons living with dementia (PLWD) than those without dementia. Conditional on COVID‐19 in the 2020 cohort, White PLWD were at higher risk of hospitalization compared to White persons without dementia (aOR 1.31, 95% CI: 1.26–1.36) and marginal for Black PLWD (aOR 1.10, 95% CI: 1.01–1.20), no significant differences were found within other racial/ethnic groups. PLWD were 1.8 times (aOR 1.78, 95% CI: 1.72–1.84) more likely to die within 30 days of COVID‐19 on average. Within racial/ethnic groups, the estimate for White PLWD, compared with White persons without dementia, was highest (aOR 2.01, 95% CI: 1.92–2.10), followed by Black PLWD (aOR 1.55, 95% CI: 1.41–1.70), and smallest among Hispanic PLWD (aOR 1.37, 95% CI: 1.24–1.50). PLWD hospitalized with COVID‐19 were 1.6 times (aOR 1.59, 95% CI: 1.52–1.67) more likely to die within 30 days than similar persons without dementia. Estimates from the 2021 cohort, when vaccines were available to older persons, were similar to those in 2020.ConclusionsCommunity‐dwelling PLWD experienced worse outcomes after a COVID‐19 diagnosis than their counterparts without dementia. Results demonstrating higher mortality, but not hospitalization rates, for all races/ethnicities except White PLWD suggest there may have been differential care/treatment that point to potential health care system inequities that persisted into 2021. Understanding the mechanisms underlying these differences may improve ongoing care for community‐dwelling PLWD.
Reference intervals for plasma, urinary, and salivary concentrations of free metanephrines in dogs: Relevance to the diagnosis of pheochromocytoma
Authors: van den Berg Marit F. , Kooistra Hans S. , Grinwis Guy C. M. , van Nimwegen Sebastiaan A. , van Faassen Martijn , Kema Ido P. , Teske Erik , Galac Sara 
Published: January 2023

AbstractBackgroundMeasurement of free metanephrines is recommended for screening of pheochromocytoma (PCC) but requires appropriate reference intervals (RIs).Hypothesis/ObjectivesTo report RIs for plasma, urinary and salivary concentrations of free metanephrines and to determine the diagnostic performance of plasma free normetanephrine (pNMN) and metanephrine (pMN) concentrations in dogs with PCC, hypercortisolism (HC), and nonadrenal illness (NAI).AnimalsEighty healthy dogs, 11 PCC dogs, 25 HC dogs, 6 NAI dogs.MethodsPlasma, urine, and saliva were collected prospectively from healthy dogs, and free metanephrine concentrations were determined by liquid chromatography‐tandem mass spectrometry (LC‐MS/MS). In addition, medical records of dogs that had plasma free metanephrine concentrations measured by LC‐MS/MS between 2018‐2021 were studied retrospectively.ResultsThe RIs for free metanephrines in plasma, urine and saliva are reported. Dogs with PCC had significantly higher pNMN than dogs with HC (P < .001) and NAI (P = .002). The PCC dogs had significantly higher pMN than HC dogs (P < .001), but not higher than NAI dogs (P = .29). Using the upper reference limit, pNMN (>3.56 nmol/L) showed high sensitivity (100%, 95% confidence interval [CI]: 72‐100) and specificity (94%, 95% CI: 79‐99) for diagnosis of PCC, whereas pMN (>2.49 nmol/L) showed moderate sensitivity (73%, 95% CI: 39‐94) and high specificity (94%, 95% CI: 79‐99).Conclusions and Clinical ImportanceWith establishment of these RIs, biochemical testing for PCC in dogs can be substantially improved. Measurement of pNMN is superior to pMN in dogs with PCC.
Testing materials to mitigate terrestrial organic contamination of meteorites: Implications for collection, curation, and handling of astromaterials
Authors: Tunney Libby D. , Hill Patrick J. A. , Herd Christopher D. K. , Hilts Robert W. 
Published: January 2023

AbstractOrganic matter in astromaterials can provide important information for understanding the chemistry of our solar system and the prebiotic conditions of the early Earth. However, once astromaterials reach the Earth's surface, they can be readily contaminated through contact with the Earth's surface as well as during processing and curation. Here, we investigate how typical handling and curation materials interact with meteorite specimens by documenting hydrophobic organic compound contamination in the laboratory environment and on materials that might be used for their collection and storage. We use gas chromatography–mass spectrometry analysis of soluble organic compounds in dichloromethane extracts of these materials to gain insights into what materials and methods are best for the collection and curation of astromaterials. Our results have implications for how extraterrestrial samples—especially those containing significant intrinsic organic matter—are handled and curated to preserve them in their most pristine states. Following recommendations of other researchers in the area of returned sample curation, we advocate for a thorough investigation into the materials used in handling and curation of meteorites to create a contamination baseline to inform soluble organic analyses on astromaterials and enable the discrimination of terrestrial and extraterrestrial compounds.
Spatiotemporal process of long‐distance seed dispersal in a pantropically distributed sea hibiscus group
Authors: Yamazaki Yuri , Kajita Tadashi , Takayama Koji 
Published: January 2023

AbstractLong‐distance dispersal (LDD) of seeds plays an essential role in the migration of plants to a new habitat and maintaining gene flow among geographically isolated populations. Pantropical plants with sea‐drifted seeds, which have one of the largest distributions in all flowering plants, have achieved their global distribution by LDD. However, the spatiotemporal processes to achieve the wide distribution and the role of LDD in it have not yet been elucidated. In this study, we conducted phylogenomic analyses on the plastome, genome‐wide nuclear SNP, and low‐copy gene data of Hibiscus tiliaceus and its relatives. The dated phylogeny suggested that global expansion started approximately 4 million years ago (Ma), and species diversification occurred 1 Ma. Plastome phylogeny confirmed the nonmonophyly of the haplotypes in the two widely distributed coastal species, H. tiliaceus and H. pernambucensis. In contrast, genome‐wide nuclear SNP phylogenies demonstrated clear genetic segregation among species and/or geographical regions. Ancestral polymorphisms in chloroplast genomes shared among widely distributed species have remained below the range of rapid expansion and speciation of marginal populations. This study demonstrated that the LDD of sea‐drifted seeds contributed to the rapid expansion and pantropical distribution of sea hibiscus in the last few million years, and adaptation to local environment or isolation by regional effect after LDD promoted speciation, suppressing gene flow.
Mental and Physical Health Trajectories of Norwegian Parents and Children before and after Union Dissolution
Authors: Kravdal Øystein , Wörn Jonathan 
Published: January 2023

AbstractThe aim was to examine the mental and physical health trajectories of mothers, fathers, and children before and after union dissolution. Register data covering the entire Norwegian population, and including information on consultations with general practitioners in 2006–2018, were used. Constant unobserved characteristics were controlled for with individual fixed effects. As judged by the number of consultations, mothers’ and fathers’ mental health deteriorates before the dissolution but improves immediately afterwards. In contrast, a worsening mental health among children before the dissolution is followed by an even more adverse development afterwards. There is only modest evidence of predissolution increases in noninfectious physical diseases, but more clearly rising numbers afterwards especially for mothers and daughters. Less adverse trends are seen for infections, although mothers experience a sharp temporary increase at the breakup time. On the whole, mothers’ health is more adversely affected by dissolution than that of fathers. Daughters may have a disadvantage compared to sons, but results vary across model specifications. The results suggest that effects on children's health do not operate through parents’ health. With respect to union type, the health changes before and after dissolution of a consensual union are not very different from those before and after marital separation.
Care for Transactions
Authors: Bailey Adrian J. , Breines Markus , Emmerson Phil , Esson James , Halvorsen Sam , Hope Jessica Chloe , Joronen Mikko , Koh Sin Yee , Krishnan Sneha , Lai Karen , McFarlane Colin , McLean Jessica , Reid Louise , Sparke Matthew 
Published: January 2023

AbstractIn this editorial we ask key questions about what it means to publish ‘a journal’ in a world of publishing which is driven by individual article metrics and online access. Seeing the value of journals as venues for intellectual debate, we therefore set out a renewed vision as to how the Transactions of the Institute of British Geographers can provide space for more collective and collaborative approaches to geographical debate. This approach revolves around the idea of ‘transactions’ itself and creating spaces in the journal for more commentary, debate and dialogue, alongside continuing to publish landmark papers.
Alternatives to blood donor deferral of gay, bisexual, and other men who have sex with men: Acceptability of screening the sexual risk behavior of all blood donors
Authors: Fisher William A. , Kohut Taylor , Woo Hyunjin , Haw Jennie 
Published: January 2023

AbstractBackgroundBlood operators screen donors to reduce the risk of transfusion‐transmitted infections (TTIs). Many are evolving screening procedures from those that defer all who have had a sexual interaction with gay, bisexual, or other men who have sex with men (gbMSM) to an approach that assesses individual donors' recent sexual risk behavior with any partner.Study Design and MethodsA representative sample of current blood donors (N = 1194) was recruited online and randomized to complete either the existing (at the time of the study) Canadian Blood Services' donor questionnaire (DQ) that screens out those with recent gbMSM sexual experience, a modified donor questionnaire (MDQ) that assesses individuals' recent sexual behavior with any partner, or an MDQ that assesses individual sexual behavior with any partner and explains why these questions are asked. Respondents were asked for their perceptions concerning difficulty, comfort, and acceptability of these screening questionnaires.ResultsAcross experimental conditions, current donors regarded screening questionnaire difficulty to be low; discomfort in responding was minimal; screening questionnaires were perceived to be relatively inoffensive and justified, and very few donors would cease donating if the screening questionnaire they responded to became the one in general use. Some minor sex differences were observed, and in some cases, perceptions of the MDQ with explanation were somewhat more positive than those of the DQ and MDQ without explanation.DiscussionAn individual risk behavior screening approach appears to be acceptable to current blood donors as an alternative to screening out all who have recently engaged in gbMSM sexual interactions.
Impact of early palliative care on the quality of life in caregivers of cancer patients: A systematic review
Authors: Agustina Rismia , Ispriantari Aloysia , Konlan Kennedy Diema , Lin Mei‐Feng 
Published: January 2023

AbstractBackgroundMaintaining caregivers' quality of life (QoL) is critical to sustaining the care needed for cancer patients. One of the interventions applied to cancer patients' caregivers is early palliative care (EPC).AimsThis systematic review synthesized the implementation of EPC on the QoL of caregivers of cancer patients.MethodsThe search was undertaken using seven electronic databases: Medline, Embase, CINAHL, CENTRAL, Web of Science, Scopus, and ProQuest Dissertation & Theses (PQDT). The search strategy integrated relevant terms of early palliative care, caregivers, cancer, and quality of life and was conducted until March 14, 2022. The thematic data analysis approach was used to integrate the results.ResultsUsing advanced search features, 4193 studies were obtained on the initial search. After screening and quality assessment, eight studies were included. Eight studies depicted that EPC interventions were delivered for caregivers of patients with advanced cancer, that is, those with a life expectancy of at least 4–24 months or considered intermediate to poor prognosis. One study provided the intervention for caregivers of patients newly diagnosed with cancer. None of the studies had the same protocol or content in delivering EPC for caregivers. Four studies gave similar details on addressing the strategies for caregivers in several aspects, including physical, psychological, social, and spiritual. There was no difference in the QoL between caregivers with cancer patients who received EPC compared with usual care. EPC was noted to influence other factors, such as caregivers' psychological distress and burden.Linking evidence to actionThe data on EPC interventions portray no beneficial effects on the QoL of caregivers with cancer patients. Further studies on developing standard protocols of EPC, multidisciplinary team, and how early it should be given to caregivers are strongly recommended.