bluuebunny/crossref_metadata_2025_split huggingface dataset:
Đặc điểm lâm sàng và đột biến gen RB1 ở bệnh nhân u nguyên bào võng mạc một mắt
Authors: Linh Đào Nguyễn Hà , Huy Nguyễn Văn , Văn Phạm Trọng , Khánh Trần Vân 
Published: January 2023

U nguyên bào võng mạc (UNBVM), một bệnh ác tính nội nhãn thường được chẩn đoán ở trẻ em, phần lớn là do đột biến bất hoạt của cả hai alen của gen RB1. Chẩn đoán UNBVM chủ yếu dựa vào bệnh cảnh lâm sàng và cận lâm sàng. Đây là khối u không thể sinh thiết trước khi mổ cắt bỏ nhãn cầu do nguy cơ gây phát tán tế bào ác tính ra ngoài, do đó chẩn đoán hình ảnh và xét nghiệm di truyền có ý nghĩa quan trọng. Trong nghiên cứu này, 16 bệnh nhân bị bệnh một mắt cần cắt bỏ nhãn cầu cho thấy tuổi phát hiện trung bình là 26,3 ± 18 tháng. Triệu chứng đầu tiên hay gặp nhất là ánh đồng tử trắng với 81,3%. Đa số bệnh nhân mắc bệnh ở giai đoạn E (chiếm 93,7%) và có duy nhất 1 bệnh nhân có tiền sử gia đình (chiếm 6,3%). Tỷ lệ bệnh nhân bị bong võng mạc cao chiếm 56,3%. Nghiên cứu phát hiện 14 loại đột biến trên 12 bệnh nhân, trong đó có phát hiện cả đột biến trên exon (11/14) và đột biến vị trí cắt nối exon - intron (3/14). Trong 11 đột biến trên exon có 10 đột biến điểm (2 đột biến lệch khung, 7 đột biến tạo mã kết thúc và 1 đột biến sai nghĩa) và 1 đột biến mất đoạn lớn. Trong 14 loại đột biến, có 1 đột biến mới chưa được công bố.
DETECTION OF GENETICALLY MODIFIED RICE LOCALLY AVAILABLE IN PUNJAB, PAKISTAN
Authors: LATIF A , SHAFIQUE MT , BANO M , BIBI A , BIBI T , GULNAZ S , KHAN RAR , MALHI AR , SARFRAZ S , AHSAN A , IQBAL HMN , LATIF A , NAZAR MZK , ASIF M 
Published: January 2023

Rice (Oryza sativa L.) is an important cereal crop that provides food to half of the world's population. Pakistan's traditional and premium quality rice is mostly exported to Europe. Transgenic or genetically modified rice (GM RICE) has been developed in the USA, China, and other countries, like herbicide-tolerant Liberty-Link rice (LLRICE06, LLRICE62, LLRICE601) and insect-resistant Bt-63. International and national biosafety regulations allow countries to stop the import of any genetically modified organism (GMO) due to its possible safety concerns. PCR-based methods are recommended for the accurate detection of GM rice. Qualitative PCR is used to detect the presence or absence of GMOs in a rice sample. The objective of this study was to check the presence of GMOs in the rice samples collected from rice-growing areas in Punjab. Eighty-two rice samples were collected randomly from various markets/locations in rice-growing areas of Punjab for this study. Twelve bulks were prepared to represent eighty-two rice samples. The CTAB method was used to extract the DNA from rice samples to analyze it. PCR of rice bulk samples was performed using primers specific for SPS, CP, p35S, tNOS, nptII, Hpt and Bt 63 rice. Positive and negative controls were included in each PCR. Primers specific for chloroplast (CP) and Sucrose phosphate synthase (SPS) genes were used to confirm DNA quality for amplification. Then, primers specific for the cauliflower mosaic virus (CaMV) 35S promoter and the Agrobacterium nopaline synthase (NOS) terminator were used for the detection of GM rice through PCR, neomycin phosphotransferase II (nptII) and Hygromycin phosphotransferase (Hpt) were used as a selectable marker and Bt 63 rice was used in insect resistance. The gel electrophoresis of PCR was conducted using a DNA ladder and then taking of the image was through gel documentation system for visualization and analysis. According to the results, all the rice bulks representing the eighty-two rice samples were negative for p35S, tNOS, nptII, Hygro and Bt 63 rice event. These findings are encouraging and demonstrate that rice grown in kalar track of Punjab, Pakistan, is non-GMO. Such surveillance and monitoring would be largely beneficial to maintain the purity of our traditional non-GM rice and to avoid any possible mixing of GM rice seeds, especially at the time of import. All these efforts will ensure and protect our national share in the international trade of rice.
PENGARUH KESIAPAN MENGAJAR TERHADAP SIKAP DALAM MENGAJAR MAHASISWA PENDIDIKAN TEKNIK MESIN ANGKATAN 2012 FAKULTAS TEKNIK UNIVERSITAS NEGERI PADANG
Authors: Hifnul Rizky Al Ulfa  , Ramli  , Yufrizal  
Published: January 2023

Penelitian ini bertujuan untuk mengetahui pengaruh dan seberapa besar pengaruh kesiapan mengajar terhadap sikap dalam mengajar mahasiswa Pendidikan Teknik Mesin angkatan 2012 FT UNP. Penelitian ini dilatar belakangi oleh kesiapan dan sikap dalam mengajar mahasiswa Pendidikan Teknik Mesin angkatan 2012 FT UNP yang relatif masih rendah. Hal ini terlihat dari masih adanya mahasiswa yang kurang dan masih belum menguasai beberapa aspek sikap dalam mengajar. Seperti keterampilan menggunakan variasi, keterampilan memberikan penguatan, dan sikap dalam menjelaskan yang dapat dilihat pada saat perkuliahan metode mengajar khusus pada semester yang lalu dan observasi yang telah penulis lakukan kepada beberapa mahasiswa yang sedang praktek mengajar disekolah. Metode yang digunakan adalah pengujian prasyarat analisis yang terdiri dari uji normalitas dan uji linearitas serta uji hipotesis yang menggunakan teknik analisis regresi sederhana dan uji T. Hasil analisis menunjukkan: (1) terdapat hubungan positif antara kesiapan mengajar dengan sikap dalam mengajar. (2) Koefisien regresi variabel kesiapan mengajar (X) sebesar 0.689 (3) jika kesiapan mengajar mengalami kenaikan satu satuan, maka sikap dalam mengajar (Y) akan naik sebesar 0.689 satuan (4) nilai T hitung > T tabel (3.206 > 2.017) maka Ha ditolak (5) bahwa ada pengaruh secara signifikan antara kesiapan mengajar dengan sikap dalam mengajar
ВИЗНАЧЕННЯ ЗАСОБІВ НЕРУЙНІВНОГО КОНТРОЛЮ ДЛЯ ДІАГНОСТУВАННЯ ТЕХНІЧНОГО СТАНУ СИСТЕМИ “ВЕРТОЛІТ І ДВИГУНИ” ВІЙСЬКОВО-ТРАНСПОРТНИХ ВЕРТОЛЬОТІВ ДЕРЖАВНОЇ АВІАЦІЇ
Authors: Жикол Павел , Бєлінська Регіна , Чусь Дмитро 
Published: January 2023

Фактор суттєвого зростання в останні роки кількості небезпечних несправностей парку військово-транспортних вертольотів типу Ми-2, Ми-2МСБ, Ми-8 та Мі-8МСБ-В державної авіації обумовлює необхідність удосконалення методів і форм їх технічного обслуговування та впровадження сучасних методів діагностування засобами неруйнівного контролю (НК) елементів конструкції системи “вертоліт і двигуни” (ВіД).Визначення переліку ефективних методів НК для поглибленого діагностування технічного стану системи ВіД потребує установлення переліку її визначальних дефектів і пошкоджень та переліку найбільш пошкоджуваних елементів конструкції системи.
У статті за результатами аналізу експлуатаційних даних щодо несправностей елементів конструкції системи ВіД указаних типів вертольотів, отриманих від усіх підрозділів державної авіації протягом 2016-2021 років, встановлено відсотковий розподіл найбільш поширених типів дефектів системи та відповідні переліки конструктивних елементів системи, на яких виникають такі дефекти.
¿NATIVOS AWAJÚN HACIENDO CIENCIA? / “ÑAUPA PUCUY”, UNA PROPUESTA DE ENSEÑANZA MUSICAL SUSTENTADA EN LA CULTURA Y TRADICIÓN CHACHAPOYA
Authors: Yoplac Acosta Manuel , Tuesta Arana Marco Antonio 
Published: January 2023

¿NATIVOS AWAJÚN HACIENDO CIENCIA?Producir cristales de veneno de serpientes y luego enviarlo a laboratorios de Estados Unidos y Alemania, pareciera una tarea exclusiva para biólogos doctores que trabajan en institutos o universidades con alta disponibilidad presupuestal y tecnológica, pero no, en el Barrio la Curva, en Santa María de Nieva, provincia de Condorcanqui en el departamento de Amazonas, esta tarea especializada la realizan dos nativos awajún, desde hace 30 años, ellos son: Ancelmo Mujat Ugkun (64) y su hijo Segundo Ancelmo Mujat Dupis (28), quienes trabajan día a día en un serpentario que ellos mismos montaron.
“ÑAUPA PUCUY”, UNA PROPUESTA DE ENSEÑANZA MUSICAL SUSTENTADA EN L A CULTURA Y TRADICIÓN CHACHAPOYANuestro Patrimonio Cultural de la Nación revela la riqueza histórica, social y cultural que posee nuestro país, algunas de ellas muy difundidas, pero encontramos otras menos investigadas y que pasan desapercibidas en su trascendencia; me refiero específicamente a los instrumentos musicales de viento denominados “Antaras6” hallados en la Laguna de los Cóndores el año 1997 y que actualmente se conservan en el Museo Leymebamba.
Trans-sectorial approaches sustainable disease control across agribusiness districts
Authors: Grenville-Briggs Didymus Laura 
Published: January 2023

Trans-sectorial approaches sustainable disease control across agribusiness districts
Here, Professor Laura Grenville-Briggs shares her stance on working together to counter the threat of oomycete diseases, focussing on trans-sectoral approaches to support sustainable plant and fish production systems in Europe. Oomycetes-microbes that superficially resemble fungi- are devastating pathogens affecting many plants and animals. Oomycete diseases in our agriculture, horticulture and aquaculture production systems, as well as natural or managed ecosystems constitute a significant threat to food security, environmental sustainability and economic stability. Moreover, under current climate change predictions, oomycete diseases are predicted to spread polewards (1) and, with more unpredictable weather patterns, are likely to be more disruptive in the future.
Who am i? Multicultural identities in the Roman Empire
Authors: Maier Felix K 
Published: January 2023

Who am i? Multicultural identities in the Roman Empire
In this second installment for Open Access Government, Prof Dr Felix K Maier, Professor for Ancient History at University of Zurich, explores multicultural identities in the Roman Empire. His history research project analyzes the dynamics of different identities in the Roman Empire from around 50-150 AD. My project aims to discern the often-paradoxical dynamics of identities in a multicultural empire and stimulate a discussion about hidden aspects of social interactions that still need to be properly understood. Although the Roman era is entirely different to our times, some critical questions from the past relate to today's world in which mechanisms of social and political distinction also lead to open or concealed conflicts.
A holistic approach to assessing soil health
Authors: Sprunger Christine 
Published: January 2023

A holistic approach to assessing soil health
In this Q&A, Dr Christine Sprunger, Assistant Professor of Soil Health in the Department of Plant, Soil, and Microbial Sciences assesses the chemical, physical, and biological processes of performing soil health assessments. With her research focusing on the intersection of agriculture and the environment, Dr. Sprunger notes how soil health has gained heightened attention from both farmers and scientists because of its association with agronomic performance and environmental sustainability, evaluating soil respiration, active carbon, soil protein, beneficial free-living nematodes. Dr. Sprunger, in this interview, analyses the importance of soil health research, finding the link between soil health and ecosystem services, how climate change influences soil health, and the future of soil health research in a factsheet for farmers interested in soil assessment.
Assessing Per- and Polyfluoroalkyl sustances (PFAS) in urban, rural, and minority-owned agriculture in the U.S.
Authors: Duncan Candice M 
Published: January 2023

Assessing Per- and Polyfluoroalkyl sustances (PFAS) in urban, rural, and minority-owned agriculture in the U.S.
Assistant Professor Dr Candice M. Duncan explores how as the global community aims to feed the 8 billion people on the planet, assessing PFAS substances in urban and rural agriculture becomes an important component of the mission. Science's pursuit of novel and innovative methods for the collection, quantification, identification, and characterization of the approximately 4700 PFAS compounds is paramount to understanding the current and long-term effects of these "forever chemicals". Specifically in an agricultural setting. As the world aims to feed itself, PFAS substances in urban and rural agriculture become very significant. The urban or rural agriculture environments can present many challenges in identifying a PFAS source. Equally challenging is the identification and access of minority-owned agricultural lands to be included in the research. This article addresses approaches and practices for PFAS research, source identification on or near agricultural lands, and ways to engage minority-owned agriculturalists.
Oral storytelling is important for reading, writing and social wellbeing
Authors: Spencer Trina D 
Published: January 2023

Oral storytelling is important for reading, writing and social wellbeing
If there was one skill that could positively impact many other areas, such as reading, writing, and social development, wouldn't you want to teach it? Could oral storytelling be the key? The link between oral language and later reading, writing, and even social-emotional health is well established. Children with better listening and speaking skills do better on academic tasks and have more friends. But how do children become good listeners and speakers? They listen to and get regular practice telling stories orally.
Seaweed farming: Biomass production from algae
Authors: Herburger Klaus 
Published: January 2023

Seaweed farming: Biomass production from algae
Algae are a high-potential yet underexplored source of renewable biomass. Here Kaus Herburger explores whether seaweed farming be the future for biomass production? The increasing demand for energy required for transport, heating and electricity is exhausting the world's natural resources and results into habitat loss, pollution and an aggravation of anthropogenic climate change. In order to meet future energy needs and comply with mandated CO2 reductions, it will be vital to utilise a wide range of sources for renewable materials and energy. A high-potential yet underexplored source of renewable biomass are algae, which are dominating the oceans as primary producers and can help overcoming shortcomings of classical land-based biomass production by serving as a pillar of the blue economy.
The euPOLIS vision: Improving well-being with nature-based solutions
Authors:   National Technical University of Athens
Published: January 2023

The euPOLIS vision: Improving well-being with nature-based solutions
Back in the 1800's people started moving from rural to urban areas. This urbanization process was motivated by many factors, including better education, housing, access to work, and less time and expense of commuting and transportation. For many years, an increasing trend of urbanization was observed, followed by set of harmful phenomena, such as alienation, increased cost of living, and mass marginalization. Today, we are facing the consequences that emerged. The adverse effects of urbanization took a toll on peoples' mental and physical health. On the one hand, mental health is affected by stressors and factors, such as overcrowded and polluted environment, high levels of violence, and reduced social support. On the other hand, urbanization is associated with increased risk of asthma, due to the exposure to air pollutants, such as nitrogen dioxide (NO2) and carbon monoxide (CO). Both cases require for prompt actions/solutions.
Wicked-Schisto: The wicked public health problem of Schistosomiasis and the interdisciplinary research helping to control it
Authors: Lamberton Poppy 
Published: January 2023

Wicked-Schisto: The wicked public health problem of Schistosomiasis and the interdisciplinary research helping to control it
Over 240 million people have schistosomiasis, a neglected tropical disease (NTD), caused by parasitic worms called Schistosoma. Over 90% of infected people live in sub-Saharan Africa. Most have long-term subtle morbidities such as abdominal pain, fatigue and diahorrea. Symptoms often overlap with other diseases found in the same areas, including malaria and intestinal worms. This results in complex, hard-to-monitor illnesses, making it difficult to know when a drug treatment or other intervention is successfully improving population health. The disease also reduces physical and cognitive development, school and work attendance and productivity, exacerbating the poverty cycle. Chronic infections cause severe organ damage, cancer and ~200,000 deaths a year. Despite 1 in 33 people in the world being infected and these devastating effects, control efforts lag behind diseases such as malaria, HIV and TB. Here Poppy Lamberton, Professor of Global Health at the University of Glasgow, explores how she is leading an interdisciplinary team aiming to identify cost-effective, sustainable interventions for schistosomiasis, a devastating neglected tropical disease.
Killing cancer softly: The resolution of cancer lies in tumor cells
Authors: Panigrahy Dipak 
Published: January 2023

Killing cancer softly: The resolution of cancer lies in tumor cells
Dr Dipak Panigrahy, M.D., an Assistant Professor at Harvard Medical School looks at killing tumor cells to resolve the cancer epidemic. For decades, the standard paradigm in cancer has been to kill tumor cells either directly, via cytotoxic chemotherapy, radiation, or target-selective inhibitors, or indirectly through immune-mediated or anti-angiogenic approaches. However, in 1956, Dr. Laszlo Révész first demonstrated that co-injection of irradiated dead cells with tumor cells reduced the number of tumor cells needed to produce tumors in rodents, and accelerated tumor progression (Révész phenomenon) (1). We demonstrated that cytotoxic cancer therapy stimulated cancer growth via cell debris, as our studies are consistent with previous research on radiation-generated apoptotic (dead) tumor cells. Dead-cell-stimulated growth is a natural part of the tissue regeneration cycle, whereas debris is interpreted by the tissue as an injury signal and stimulates wound healing and regeneration. Cancer can be viewed as run-away wound healing and regeneration that fails to be self-limited.
Brain health conditions: Excellence in psychedelic treatments
Authors: Hawrot Tadeusz , Badcock David 
Published: January 2023

Brain health conditions: Excellence in psychedelic treatments
Psychedelic treatments open up an unparalleled window of opportunity, but we need to get ready for their roll-out. Mental healthcare is in crisis, and we don't have the tools to truly help millions of Europeans in need. In the EU, a shocking number of over 100 million people are affected by mental health conditions and alcohol use disorder and 56 000 die by suicide every year. And yet, few novel treatments have been developed by the pharmaceutical industry in the last several decades. We urgently need more innovation and psychedelic-assisted therapies (PATs) are emerging as a potent new class of novel treatments for mental, neurological and substance use disorders, as indicated by the rapidly growing, rigorous, and compelling body of research. In conjunction with proper psychosocial support, they hold the potential to provide safe, rapid-acting, and robust clinical improvements with durable effects.
Strategi Penanganan Pembiayaan Bermasalah Pada PT. BPRS Puduarta Insani Di Era Covid-19
Authors: Fira Annisa  , Mustapa Khamal Rokan  
Published: January 2023

Masa pandemi covid-19 merupakan wabah penyakit yang membawa perekonomian masyarakat menurun drastis karena dari wabah ini berakibat pada berhentinya roda usaha masyarakat dan tidak hanya itu sektor perbankan, industry dan lain sebagainya mendapatkan imbasnya. Sehingga income masyarakat menurun dan berakibat juga pada pemenuhan kewajiban terutama pada pembayaran angsuran pembiayaan di Bank Pembiayaan Rakyat Syariah (BPRS) Puduarta Insani. Dalam penelitian ini merupakan sebuah jenis penelitian kualitatif deskriptiv yang mana peneliti melakukan studi lapang untuk mendapatkan informasi yang akurat dengan melakukan wawancara, dari hasil tersebut dilakukanlah analisis data dan kreadibilitas data guna mendapatkan hasil yang baik. Sehingga menghasilkan bahwa Bank Pembiayaan Rakyat Syariah (BPRS) Puduarta Insani memberikan kelonggaran dan tidak semuanya tergantung pada masing-masing lembaga keuangan yang memiliki kebijakan tersendiri, mulai dari pengurangan jumlah bayar angsuran.
Analisis Faktor-Faktor yang Mempengaruhi Surflus Underwriting Dana Tabarru' Studi Kasus AJB BumiPutra 1912 Cabang Medan
Authors: Ayub Tambak  , Atika  
Published: January 2023

Abstract
This study aims to determine the factors that affect the underwriting surplus on the tabarru' fund in the sharia insurance company AJB Bumiputra1912 Syariah Medan branch. The factors contained in this study are the net contribution, claims expense, and the results of this research investment using descriptive qualitative research methods. By using analysis and interview methods and with previous data, this research was conducted so that the company could be stable in managing the underwriting surplus in tabarru funds, and could improve the quality and quality of the company, especially Ajb bumiputra1912 sharia field branch.
Keyword: Surplus underwriting, sharia life insurance, tabarru' funds net contribution, claims and investment
Access to and Use of Agricultural Information among Maize Farmers in Ejura Sekyedumase Municipality
Authors: Mensah Emmanuel , Osei Collins Kwabena , Asantewaa Jennifer Karikari , Aboagye Richard 
Published: January 2023

Purpose: To examine the access to and use of agricultural information among maize farmers in the Ejura-Sekyedumase Municipality in Ashanti Region
Methodology: A quantitative approach was used through the use of cross-sectional survey design. A multi-stage sampling method was used to select 170 maize farmers from the communities for the study. The data was collected using a semi-structured questionnaire and analysed using SPSS version 23.0 software. Frequencies, Percentages, Mean, Chi-square Test of Independence and Kendall’s Coefficient of Concordance were used for data analysis.
Findings: The study found that the most utilized source of agricultural information by maize farmers in Ejura Sekyedumase Municipality was agricultural extension agents. It was also observed that there was a significant relationship between farm ownership type, educational level, access to credit, extension visits, farming experience, and access to agricultural information. The study also found that the main agricultural information needs of the maize farmers in Ejura Sekyedumase Municipality were disease and pest management. Also, the inadequate number of extension agents was the main challenge faced by farmers in accessing and using agricultural information in the municipality.
Conclusion: The study conclude that farmers received most of their information from agricultural extension agents, radio and farmers. Access to agricultural information is influence by socio-economic characteristics of farmers.
Recommendations: The study recommends that extension agents to be well equipped and trained, as well as increasing their number by the government through the Ministry of Food and Agriculture. Also, farmers must be well communicated to and educated using local strategies as well as encouraging them to join Farmer Based Organisations (FBOs).
PENGARUH PERBANDINGAN CAMPURAN 50% LIMBAH SAWIT DAN 50% KOTORAN SAPI TERHADAP PROSES TERJADINYA BIOGAS
Authors: Rahmadi Hairian 
Published: January 2023

Gas ini berasal dari pencampuran limbah cair sawit dan kotoran sapi. Pembuatan biogas dari limbah sawit, khususnya limbah cair sawit dan sapi ini berpotensi sebagai energi alternatif yang ramah lingkungan, karena selain dapat memanfaatkan limbah sawit dan ternak, sisa dari pembuatan biogas yang berupa slurry dapat dimanfaatkan sebagai pupuk organik yang kaya akan unsur-unsur yang dibutuhkan oleh tanaman. Tujuan penelitian ini adalah untuk mengetahui pengaruh perbandingan campuran limbah cair sawit dan kotoran sapi terhadap terjadinya biogas dan warna nyala api. Pengujian penelitian ini mengunakan drum, ban dalam mobil, pressure gouge dan media kompor gas. Pada hasil pengujian biogas pada hari ke 10 tapi tidak signifikat, setelah hari ke 15 sampai 20 hari terjadi peningkatan reaksi terjadinya biogas.