bluuebunny/crossref_metadata_2025_split huggingface dataset:
Overdiagnosis of lobular carcinoma of breast- A review of histomorphological features and immunohistochemistry: A case series
Authors: Rajkumari Priyadarshini , Pallipady Aravind 
Published: March 2023

: Invasive lobular carcinoma (ILC) accounts for 5%–15% of all invasive breast cancers (BCs) and is the second most common type of BC behind invasive ductal carcinoma (IDC) of no special type. ILC of the breast is characterized morphologically by small, noncohesive cells that infiltrate the stroma in a single-file pattern(Indian file pattern). ILC tumours display features associated with a good prognosis, being low grade, oestrogen receptor positive and is mainly associated with the complete loss of E-cadherin (E-cad) expression.To review the cases of invasive lobular carcinoma and to immunohistochemically categorize IDC and ILC.This is a retrospective study including all the modified radical mastectomy cases of invasive lobular carcinoma of breast reported in the department of Pathology of a tertiary care centre from January 2021 to January 2022. Histopathological and immunohistochemical analysis of those cases were reviewed.We encountered 10 cases of invasive lobular carcinoma of breast from January 2021 to January 2022. The average age of the patients was 55.9 years old (35–72). The classic presentation was a breast lump found in 100% of the cases. On physical examination, breast carcinoma was suspected in all the patients. The average size of the tumours was 4.5 cm (1.4– 9cm). Out of those 10 cases, 4 cases were right sided lesion and modified radical mastectomy was performed in all the 10 cases. All the 10 cases were diagnosed as invasive lobular carcinoma on histopathology and review of those cases showed 7 out of 10 cases to be IDC. Those cases showed pitfalls in histomorphological analysis which were later confirmed by immunohistochemistry. The findings are presented in the study.Our study found that there was a histomorphological pitfall in the diagnosis of IDC. In ambiguous cases with histologically equivocal features, a strong, complete, membranous E-cadherin expression may help in resolving the problem and in aiding in the subclassification of invasive breast carcinoma.
An unusual case of mediastinal mass with pleural and pericardial effusion
Authors: Dsouza Shirley Maria , Rao Purnima S 
Published: March 2023

Myeloid sarcoma is a tumor mass consisting of myeloid blasts, with or without maturation, occurring in an anatomical site other than bone marrow. More than 2000 case reports so far, only few comprehensive studies have been done, which reflects the rarity and difficulties in treatment of this neoplasm.: A 17-year-old female presented with complaints of neck swelling since 2 months, breathlessness since 5 days. PET CT- Bilateral pleural and pericardial effusion Large mediastinal mass, multiple enlarged lymph nodes and appendicular skeleton showing increased FDG uptake. CT-Guided biopsy of the mediastinal mass: Uniform blue cells in sheets.: CD45-Weak positive CD20, CD3, TdT-Negative CD99-Diffuse strong positive Parallelly, blood and bone marrow examination was done. Peripheral smear-80% blasts. Bone marrow-Monomorphous population of myeloblasts.: About 21% of Myeloid Sarcomas (MS) are reported to occur in the mediastinum. Clinical presentation is dependent on tumour location, with symptoms due to tumour mass effect or local organ dysfunction. Recent studies show a misdiagnosis of 25-47%, with Hodgkin's lymphoma, lymphoblastic lymphoma, DLBCL, Ewing's sarcoma, thymoma, round blue cell tumours, or poorly differentiated carcinomas, mostly due to inadequate immunophenotyping. It was not corrected until a diagnosis of acute leukaemia was later established by bone marrow biopsy or peripheral blood examination.: Recognition of MS with/without AML is essential for prognosis. Correlating radiological, hematological, bone marrow and flowcytometry features with histomorphology and immunohistochemistry of the tumor is essential. A rare possibility of MS should be kept in mind for mediastinal masses for timely diagnosis and treatment.
Transformação digital em pequenos negócios no contexto da pandemia da Covid-19: uma revisão da literatura
Authors: Albuquerque Rodrigues Gerlane Pereira de , Guimarães Júnior Djalma Silva 
Published: March 2023

Este artigo trata de uma revisão sistemática da literatura referente a adoção de tecnologias digitais e inovação de processos, cujo objetivo é investigar a ocorrência de transformação digital em pequenos negócios, acelerada a partir das restrições trazidas à atividade econômica pela pandemia da Covid19. O levantamento dos artigos foi realizado em três bases de dados: Web of Science, Google Acadêmico e Scopus. Identificou-se uma significativa presença de estudos exploratórios e grande quantidade de pesquisas que evidenciam a presença da transformação nas empresas e no comportamento dos consumidores, porém, ainda é pequena a quantidade de estudos que investigam esta transformação digital nos pequenos negócios. A pesquisa conseguiu identificar evidências de incipiente transformação digital nos artigos selecionados. De forma empírica, sem o adequado planejamento, as mudanças na comercialização dos produtos através das redes sociais e aplicativos de mensagens possibilitaram a sobrevivência dos pequenos negócios com o surgimento da pandemia. Por esta razão, propõe-se a continuidade dos estudos, tendo como foco, a digitalização nos pequenos negócios impulsionada pela pandemia.
Overin nadir tümörü: Sklerozan stromal tümör; 7 olgu sunumu ve literatürün gözden geçirilmesi
Authors: AYAZ Duygu , SAYHAN Sevil , KARADENİZ Tuğba , DEMİR KEÇECİ Sibel , AKÖZ Gamze 
Published: March 2023

Sklerozan stromal tümörler (STT), genellikle yaşamın 2-3. dekadında genç kadınlarda görülen nadir benign over tümörleridir. Over stromal tümörlerinin %2-6’sını oluştururlar. Çalışmamızda, İzmir Tepecik Eğitim ve Araştırma hastanesi patoloji bölümünde 2011-2020 yılları arasında tanı alan 7 sklerozan stromal tümör olgusunu, klinik ve histopatolojik bulgularını tekrar gözden geçirerek literatür eşliğinde sunduk .
Hastalarımızın yaş ortalaması 34.4 olup 2 hasta postmenopozal dönemdeydi. Olguların 4’ünün klinik takibi mevcut olup 1 hastada operasyondan 7 yıl sonra nüks görüldü. Makroskopik olarak tümörlerin çoğu tamamıyla solid görünümdeydi. Mikroskopik olarak tüm olgularda ödemli ve /veya kollojenden zengin hiposellüler alanlarla ayrılan hipersellüler alanlardan oluşan psödolobüler düzenlenim mevcuttu. Tümör, iğsi şekilli hücreler ve bol berrak – eozinofilik şekilli yuvarlak hücrelerden oluşuyordu.
Çok nadir görülmeleri nedeniyle SST de preoperatif tanı mümkün değildir. Özellikle frozen çalışılan olgularda tipik histopatolojik bulgularla doğru tanı konulması, genç kadın hastalarda fertilite koruyucu cerrahinin uygulanabilmesi açısından önem taşır.
Sünnet Sonrasında Çocukların Duygusal Stres Yaşama Durumunun Belirlenmesi
Authors: ÇİMKE Sevim , ARAS Necip Fazıl 
Published: March 2023

Amaç: Bu çalışmada, sünnet sonrasında çocuklarda duygusal stres yaşama durumlarının belirlenmesi amaçlanmıştır.
Materyal ve Metot: Araştırma tanımlayıcı, bir araştırma olarak tasarlanmıştır. Araştırma verilerinin toplanmasında klinikte sünnet olan ve araştırmaya dahil edilme kriterlerini sağlayan çocukların ebeveynlerine, sünnettin üzerinden 1 ay geçmiş olan ebeveynlere online olarak hazırlanmış olan anket formu gönderilerek çalışmaya katılmaya davet edilmiştir. Araştırma Ekim 2021- Şubat 2022 tarihleri arasında yapılmıştır. Araştırmaya 228 gönüllü ebeveyn katılmıştır. Araştırmanın verilerinin toplanmasında çocuk ebeveyn tanıtım bilgi formu ve Çocukluk Çağı Travma Sonrası Duygusal Stres Ölçeği (ÇÇTSDSÖ) kullanılmıştır.
Bulgular: Çocukların %93,90’unun sünnet olması için tıbbı bir gereklilik olmadığı belirlenmiştir. Sünnet sonrası en sık yaşanan fiziksel semptomların ağrı (% 86,0), yara yerinde şişme (% 63, 60) olduğu belirlenmiştir. Çalışmada ÇÇTSDSÖ puan ortalaması … bulunmuştur. Sünnet sonrası ağrı, kanama ve şişme semptomları yaşayan çocukların ÇÇTSDSÖ puanları semptom yaşamayan çocuklardan yüksek olduğu belirlenmiştir (p=0,022; p=0,002; p=0,030). Çalışmada sünnet öncesi işleme hazırlanan, sünnetten önce ve sünnet günün doktoru ve hemşiresi ile tanıştırılan çocukların ÇÇTSDSÖ puanları diğer gruplardaki çocuklardan anlamlı şekilde düşük olduğu saptanmıştır (p=0, 009; p=0,013; p=0,029).
Sonuç: Sünnet kültürel, dini ve tıbbı yönleri olan çok boyutlu bir olgudur. Bu nedenle sünnetin etkileri değerlendirilirken toplumsal özellikleri göz ardı etmemek gerekir. Çalışmamızda çocukların sünnet sonrası duygusal stres yaşama durumlarının yüksek olmadığı belirlenmiştir.
DOKUZ EYLÜL ÜNİVERSİTESİ TIP FAKÜLTESİNDE AKRAN DESTEKLİ ÖĞRENME DENEYİMİ
Authors: OFLAS Berfu , ÖZBOYACI Cüneyt , MUSAL Berna , ÖZKÜTÜK Ayşe Aydan , ÇAVDAR Caner 
Published: March 2023

Amaç:
Akran destekli öğrenme, benzer sosyal gruplardaki kişilerin birbirlerine öğrenme konusunda yardım ettikleri, kendilerinin de öğretirken bilgi ve beceri kazandıkları işbirlikli bir eğitimdir.
Yeni bir bilgiyi edinmenin en ideal yönteminin o bilgiyi öğretme ve aktarma olduğu bilinmektedir. Akran destekli öğrenme, destek sağlayan kişilere ve akranlarına bilişsel, davranışsal ve sosyal katkılar sağlamaktadır.
Fakültemizde, intörnlerin klinik öncesi sınıftaki öğrencilerin mesleksel beceri eğitiminde görev aldıkları bir uygulama başlatılmıştır. Bu uygulamayla, önceki yıllarda mesleksel beceri eğitimi alan intörnlere uygulamaları pekiştirme ve eğiticilik deneyimi kazanma fırsatı da sağlanmıştır. Bu makalede, 2021-2022 akademik yılında Fakültemizde uygulanan akran destekli eğitim deneyiminin paylaşılması amaçlanmıştır.
Efficacy of Intravenous Ibuprofen and Acetaminophen on Postoperative Pain and Tramadol Consumption in Laparoscopic Cholecystectomy: Prospective, Randomized, Double-blinded Clinical Trial
Authors: ERSOY Zeynep , ARAZ Çoşkun 
Published: March 2023

Background: Many techniques, including multimodal analgesia, have been used to manage postoperative pain after laparoscopic cholecystectomy (LC). Although the number of studies using intravenous ibuprofen (IV) is still limited, ibuprofen has been shown to have a potential role in managing postoperative pain. The primary outcome of this study is to evaluate and compare the impact of IV forms of ibuprofen and acetaminophen on 24-hour postoperative opioid consumption and pain management in patients undergoing LC. The second outcome of the study is to evaluate the impact of ibuprofen and acetaminophen on opioid-related adverse events (ORAE).
Materials and Methods: This study was a prospective, randomized, double-blind clinical trial. Following ethical committee approval, 70 patients aged 18 to 65, American Society of Anesthesiology (ASA) score I- II, and those scheduled for LC were enrolled in the study. Patients were randomly divided into two groups. The control group (n=35) received 800 mg IV ibuprofen (group I) in 100 mL saline during surgery, while the acetaminophen group (n=35) received 1000 mg (group A). In the postoperative period, all patients received a patient-controlled analgesia (PCA) device with tramadol. The PCA device was set to a bolus dose of 10 mg and had a lockout time of 15 minutes. A blinded pain nurse assessed postoperative analgesia at 1, 2, 4, 6, 12, and 24 hours using a numerical rating scale (NRS). The incidence of postoperative nausea and vomiting (PONV), total tramadol consumption, and the need for additional analgesics during the 24-hour postoperative period were recorded.
Results: Seventy patients who underwent LC participated in this study. The use of analgesic medications was statistically lower in group I than in the other group A. NRS scores between the IV ibuprofen and acetaminophen groups were statistically similar at 1, 2, 4, 6, 12, and 24 hours postoperatively (P>0.05). 24-hour opioid consumption was statistically significantly higher in group A than in group I (P0.05). PONV rates were similar in the ibuprofen and acetaminophen groups (P>0.05). ORAEs were similar between groups.
Conclusion: Ibuprofen as part of tramadol-based multimodal analgesia reduced tramadol consumption compared to acetaminophen during the first 24 hours postoperatively following elective LC surgery. The IV ibuprofen-tramadol combination appeared superior to an acetaminophen-tramadol combination. ORAEs were similar in both groups.
INTEGRASI MATERI KEBENCANAAN PADA JENJANG SEKOLAH DASAR DI KECAMATAN NGARGOYOSO, JAWA TENGAH
Authors: Ammelia Inge , Lestari Diyah Sri , Al Ghazy Ghulam Tsabat , Wibowo Yunus Aris 
Published: March 2023

Karanganyar is an area that is prone to landslides, one of which is in Berjo Village, Ngargoyoso District. Educational integration is an effort to unify the process of changing one's attitudes and behavior in the eyes of the group in an effort to mature humans through learning. This study aims to determine the integration of disaster materials and educators' perceptions of each elementary school in landslide-prone areas, Ngargoyoso District. The approach used in this study is a quantitative approach using primary data through questionnaires and interviews. The sample technique used in this study used a purposive sampling technique with a research sample of 20 people divided into 16 teachers and 4 principals or 4 teachers and 1 principal at SD N 1 Kemuning, SD N 4 Kemuning, SD N 5 Kemuning, and SD IT Al-Hikmah. In this study, the importance of a teacher's perception of understanding disaster material to support efforts to reduce disaster risk and make fixed procedures for disaster preparedness in schools. The existence of educational knowledge in schools is expected to be an effective measure for the distribution of information regarding the integration of disaster materials.

Keywords: Disaster, Materials, Integration
Summative Assessment Using Moodle Learning Management System in Vocational High School: Teacher Perspective
Authors: Kustiaman Aditya Irfan , Wahyudin Dinn , Dewi Laksmi 
Published: March 2023

This study used a qualitative approach using descriptive methods. The research site was conducted at Cimahi City Center for Excellence Vocational High School (Center of Excellence) with teacher research participants in the curriculum and subject teachers involved as supervisors in implementing summative assessments. Data collection is conducted by conducting interviews and documentation studies on learning management systems owned by schools. The validity and reliability of the research results are checked using triangulation of data and information. As a result of the study, summative assessments using LMS Moodle were more effective over time, reduced paper usage was easy to use, and encouraged mastering technology competencies for teachers. The negative impact of using LMS Moodle on summative assessment is the student's chances of finding answers online. Anticipation can be achieved by adding a blocking feature to Moodle. LMS Moodle-based facilities and facilities support facilities are the main prerequisites for the smooth implementation of summative assessments.
Trapezoid Stress Fracture in an Olympic-Level Gymnast
Authors: Bertha Nicholas M. , Wisinski Jeffrey J. , Taylor Kenneth F. 
Published: March 2023

Case:
A 23-year-old elite-level gymnast presented with insidious-onset pain near the base of the second metacarpal. The patient was found to have a trapezoid stress fracture and was treated nonoperatively in a thumb spica cast for 4 weeks. He resumed gymnastics without limitations 8 weeks from the time of diagnosis.

Conclusion:
Trapezoid stress fractures must be considered when evaluating patients presenting with pain about the base of the index finger metacarpal, particularly those who perform activities that repetitively place high loads across the wrist. Wrist immobilization and a supervised return to participation resulted in an excellent outcome for this patient.
Adductor Branch of Terminal Divisions of the Ulnar Nerve Transfer to the Thenar Motor Branch in a High Median Nerve Palsy
Authors: Jerome J. Terrence Jose 
Published: March 2023

Case:
The author reports a 4-month-old high median nerve palsy in a 19-year-old man with right forearm fractures, stabilized with dynamic compression plates and screws. Surgical exploration revealed a large median nerve neuroma in the midarm that was excised, and the gap was bridged with sural nerve cable grafts. The extensor carpi radialis nerve was transferred to the anterior interosseous nerve in the forearm. The adductor branch of terminal divisions of the ulnar nerve was transferred to the thenar branch of the median nerve in the hand.

Conclusions:
The adductor branch of ulnar nerve transfer to the thenar motor branch in high median nerve palsy efficiently restored thumb opposition in 10 months of follow-up. In addition, the patient's grasp and pinch improved, preserving thumb adduction.
Irreducible Posterolateral Knee Dislocation
Authors: Pache Santiago , Vázquez José María , Chahla Jorge , Moatshe Gilbert , LaPrade Robert F. 
Published: March 2023

Case:
A 62-year-old male patient suffered an irreducible posterolateral knee dislocation after a horse fell on him. The left knee was slightly flexed with a medial dimple sign present. The medial retinaculum, medial patellofemoral ligament, posteromedial corner structures, and vastus medialis obliquus (VMO) muscle were incarcerated in the medial joint. An open reduction and the medial retinaculum and VMO gap were repaired, and the knee was stabilized in an external fixator for 4 weeks. At 32-month follow-up, the patient had almost full knee motion and good subjective outcomes with moderate residual joint laxity.

Conclusion:
Early clinical diagnosis of irreducible knee dislocations and emergent open reduction should be performed to reduce the risk of soft-tissue compromise.
Increasing coverage and uptake of voluntary family planning in urban areas of central-eastern Uganda: an implementation research study protocol
Authors: Kananura Rornald Muhumuza , Birabwa Catherine , Ssanyu Jacquellyn Nambi , Kizito Felix , Kagaha Alexander , Namutanba Sarah , Kyangwa Moses , Kakaire Othman , Waiswa Peter 
Published: March 2023

Abstract
Introduction
While urban areas are often perceived and reported as better off due to the wide availability of and apparent proximity to services, family planning (FP) access among the marginalized communities such as slums might be worse. Although evidence on access to FP in urban space is illusive, just like rural poor, the urban poor residents are characterized by multidimensional challenges that not only limit the population from accessing voluntary FP (VFP) services but also expose them to unplanned sexual intercourse and ultimately unplanned pregnancies and other related consequences. In this study we seek to augment and strengthen existing efforts towards increasing coverage and uptake of VFP in Jinja city and Iganga Municipality, central eastern Uganda. Our primary question is “what interventions can effectively be packaged and delivered to increase uptake of VFP and promote urban thriving.
Methods
We propose to use the Human-Centered Design (HCD) approach to understand the needs, capabilities and challenges of users and ensure stakeholder engagement in the development or adaptation of solutions and design of programs through co-creation. As such, we shall implement in three faceted phases: formative assessment, design and implementation, implementation monitoring and evaluation. Monitoring, learning, and adaptation are embedded within the implementation process with the focus of using the information to guide implementation design and learning. Building on implementation research framework such as RE-AIM (reach, effectiveness, adoption, implementation, maintenance) and Fidelity frameworks, we shall apply process monitoring and evaluation approach to address questions related to what package of FP interventions work, for whom, under what circumstances and why.
Discussion
Guided by a strong learning and implementation flexibility, we hypothesize that our implementation will provide the segmentation specific high impact interventions in an urban context. We also hypothesize that the use human-centred approach will enable us to develop a tailored package of FP interventions that match different segments in an urban setting of developing countries.
Design an Efficient FPGA Based Hardware Implementation for Real-Time Mobile Epileptic Seizure Prediction Using Deep Neural Network
Authors: SAMANTA ANU , Hatai Indranil , Mal Ashis Kumar 
Published: March 2023

Abstract
Epilepsy is a neurological condition that distresses millions of individuals throughout the world. The lives of epileptic patients are greatly influenced by the early detection of impending seizures. In this paper, Design an Efficient FPGA Based Hardware Implementation for Real-Time Mobile Epileptic Seizure Prediction Using Deep Neural Network. This research study uses correlation deep learning replicas through an FPGA enactment of the modified short-time Fourier transform (MSTFT) block to improve epileptic seizure detection. EEG data is pre-processed for time-frequency analysis of EEG segments using an FPGA-based MSTFT. Mounting-based Matrix Factorization (MMF) extract frequency bands and feature space. Seizure detection using proposed Correlation-based deep learning neural Network (CDNN) for classification. Each layers hybrid using hyperparameter optimized using Entropy-based Grey Wolf Optimizer (EGWO) algorithm. The experimental outcomes will demonstrate that our presented technique passes the traditional techniques.
Study on the influence of different fertilization regimes on the yield and bulb quality of garlic (Allium Sativum L.)
Authors: Zhang Yongtao , Song Jiabin , Zeng Xiaoping , Zhu Haimei , Zhou Lingdi , Li Zhen , Fan Xiaorong 
Published: March 2023

Abstract
Purpose: The purpose of this study was to assess the effect of microbial biofertilizer and nanofertilizer on the growth, allicin content and elemental content of garlic in China.
Method: We conducted field trial of microbial biofertilizer and germanium-containing controlled release nanofertilizer along two consecutive winter periods of 2020/2021 and 2021/2022 in a major garlic production area at Pizhou city to determine the effect of treatment in comparison to the local fertilization practice.
Result: The results revealed that the application of microbial biofertilizer and germanium-containing controlled release nanofertilizer increased the bulb yield by approximately 6-28% and 14%, respectively, compared with local fertilization practice. Meanwhile, the application of microbial biofertilizer consistently increased the allicin content of garlic in year 2021 and 2022. Furthermore, we also observed a strong positive correlation between shoot nitrate concentration at spring garlic stage and the final garlic bulb yield, implying that the accumulation of nitrate content in garlic at spring garlic stage maybe beneficial to biomass accumulation through either nutritional effect and increased chilling tolerance.
Conclusion: Taken together, our results revealed that the application of microbial biofertilizer and germanium-containing controlled release nanofertilizer can increase growth and nitrogen use efficiency of garlic in our experiment.