bluuebunny/crossref_metadata_2025_split huggingface dataset:
Depolymerization of robust polyetheretherketone to regenerate monomer units using sulfur reagents
Authors: Minami Yasunori , Matsuyama Nao , Takeichi Yasuo , Watanabe Ryota , Mathew Siby , Nakajima Yumiko 
Published: January 2023

AbstractSuper engineering plastics, high-performance thermoplastic resins such as polyetheretherketone, and polyphenylene sulfide have been utilized in industries, owing to their high thermal stability and mechanical strength. However, their robustness hinders their depolymerization to produce monomers and low-weight molecules. Presently, chemical recycling for most super engineering plastics remains relatively unexplored. Herein, we report the depolymerization of insoluble polyetheretherketone using sulfur nucleophiles via carbon–oxygen bond cleavages to form benzophenone dithiolate and hydroquinone. Treatment with organic halides converted only the former products to afford various dithiofunctionalized benzophenones. The depolymerization proceeded as a solid–liquid reaction in the initial phase. Therefore, this method was not affected by the shape of polyetheretherketone, e.g., pellets or films. Moreover, this depolymerization method was applicable to carbon- or glass fiber-enforced polyetheretherketone material. The depolymerized product, dithiofunctionalized benzophenones, could be converted into diiodobenzophenone, which was applicable to the polymerization.
Hyperfine-structure-resolved laser spectroscopy of many-electron highly charged ions
Authors: Kimura Naoki , Priti  , Kono Yasutaka , Pipatpakorn Pativate , Soutome Keigo , Numadate Naoki , Kuma Susumu , Azuma Toshiyuki , Nakamura Nobuyuki 
Published: January 2023

AbstractHyperfine structures of highly charged ions (HCIs) are favourable spectroscopic targets for exploring fundamental physics along with nuclear properties. Recent proposals of HCI atomic clocks highlight their importance, especially for many-electron HCIs, and they have been theoretically investigated by refining atomic-structure calculations. However, developments in hyperfine spectroscopy of many-electron HCIs have not proceeded due to experimental difficulty. Here, we demonstrate hyperfine-structure-resolved laser spectroscopy of HCIs in an electron beam ion trap plasma, employing the magnetic-dipole transition in the 4d95s state of 127I7+. Ion-state manipulation by controlled electron collisions in the well-defined laboratory plasma enables laser-induced fluorescence spectroscopy of trapped HCIs. The observed spectrum of evaporatively cooled ions under low magnetic fields shows characteristic features reflecting the hyperfine structures. The present demonstration using combined optical and plasma approaches provides a benchmark for state-of-the-art atomic calculations of hyperfine structures in many-electron HCIs, and offers possibilities for a variety of unexploited experiments.
The inhibition of ORMDL3 prevents Alzheimer's disease through ferroptosis by PERK/ATF4/HSPA5 pathway
Authors: Shao Yankun , Xu Yilin , Di Huang , Shi Xinxiu , Wang Yingying , Liu Hongyu , Song Lina 
Published: January 2023

AbstractAlzheimer's disease (AD) is a neurodegenerative disease with high incidence and widespread attention. There is currently no clear clarification of the pathogenesis. However, ORMDL3 causes ferroptosis in AD, and the potential mechanisms remain unclear. So, this study explore the function of ORMDL3 on ferroptosis in AD and its potential regulatory mechanisms. APPswe/PS1dE9 mice and C57BL/6 mice were induced into the mice model. The murine microglial BV‐2 cells also were induced into the vitro model. In serum samples of AD patients, ORMDL3 mRNA expression levels were upregulated. The serum ORMDL3 levels expression was positively related to the ADL score or MoCA score in AD patients. The serum ORMDL3 expression level was positively related to MMSE score or Hcy levels in AD patients. The mRNA expression of ORMDL3 in the hippocampal tissue of the mice model of AD was upregulated at one, four and eight months. The protein expression of ORMDL3 was upregulated in the mice model of AD. ORMDL3 promoted Alzheimer's disease, and increased oxidative response and ferroptosis in a model of AD. PERK/ATF4/HSPA5 pathway is one important signal pathway for the effects of ORMDL3 in a model of AD. Collectively, these data suggested that ORMDL3 promoted oxidative response and ferroptosis in a model of AD by the PERK/ATF4/HSPA5 pathway, which might be a novel target spot mechanism of ferroptosis in AD and may serve as a regulator of AD‐induced ferroptosis.
Vielseitigkeit in Neurologie und Psychiatrie
Authors: Falkai Peter 
Published: January 2023

Liebe Kolleginnen, liebe Kollegen,beide Disziplinen, sowohl die Neurologie als auch die Psychiatrie konnten ihr Wissen
in den von ihnen behandelten Erkrankungen in den letzten Jahren weiterhin deutlich
erweitern, ebenso wie sich diagnostische und therapeutische Verfahren und ihre
Langzeitprognosen stetig verbessert haben. Diese erste Ausgabe der
Fortschritte spiegelt einmal wieder die Breite der in den Fachbereichen
Neurologie und Psychiatrie behandelten Themen.
Applications of Gene Therapy in Dentistry: A Review Article
Authors: Nair Karthika , Bhat Amitha Ramesh 
Published: January 2023

AbstractGene therapy promises to possess a good prospect in bridging the gap between dental applications and medicine. The dynamic therapeutic modalities of gene therapy have been advancing rapidly. Conventional approaches are being revamped to be more comprehensive and pre-emptive, which could do away with the need for surgery and medicine altogether. The complementary base sequences known as genes convey the instructions required to manufacture proteins. The oral cavity is one of the most accessible locations for the therapeutic intervention of gene therapy for several oral tissues. In 1990, the first significant trial of gene therapy was overseen to alleviate adenosine deaminase deficiency. The notion of genetic engineering has become increasingly appealing as a reflection of its benefits over conventional treatment modalities. An example of how this technology may alter dentistry is the implementation of gene therapy for dental and oral ailments. The objective of this article is to examine the effects of gene therapy on the field of dentistry, periodontology and implantology. Furthermore, the therapeutic factors of disease therapy, minimal invasion, and appropriate outcome have indeed been taken into consideration.
Medial Femoral Condyle Corticoperiosteal Flap for Failed Total Wrist Fusions
Authors: Tee Richard , Harvey Jason N. , Tham Stephen K. , Ek Eugene T. 
Published: January 2023

Abstract
Background Recalcitrant nonunion following total wrist arthrodesis is a rare but challenging problem. Most commonly, in the setting of failed fusion after multiple attempts of refixation and cancellous bone grafting, the underlying cause for the failure is invariably multifactorial and is often associated with a range of host issues in addition to poor local soft-tissue and bony vascularity. The vascularized medial femoral condyle corticoperiosteal (MFC-CP) flap has been shown to be a viable option in a variety of similar settings, which provides vascularity and rich osteogenic progenitor cells to a nonunion site, with relatively low morbidity. While its utility has been described for many other anatomical locations throughout the body, its use for the treatment of failed total wrist fusions has not been previously described in detail in the literature.
Methods In this article, we outline in detail the surgical technique for MFC-CP flap for the management of recalcitrant aseptic nonunions following failed total wrist arthrodesis. We discuss indications and contraindications, pearls and pitfalls, and potential complications of this technique.
Results Two illustrative cases are presented of patients with recalcitrant nonunions following multiple failed total wrist fusions.
Conclusion When all avenues have been exhausted, a free vascularized corticoperiosteal flap from the MFC is a sound alternative solution to achieve union, especially when biological healing has been compromised. We have been able to achieve good clinical outcomes and reliable fusion in this difficult patient population.
Designing speaking tasks for different assessment goals
Authors: Sasayama Shoko , Norris John M. 
Published: January 2023

Abstract
This study explored the role of cognitive task complexity in designing speaking assessment tasks. A sample of 120 English learners at different proficiency levels engaged in four narrative tasks with distinct levels/types of cognitive complexity. Performances were assessed using linguistic measures and a task accomplishment rubric. Findings revealed that one of the middle-complexity tasks with moderate intrinsic, moderate germane, and low extraneous complexity elicited the best linguistic performances overall, while the lowest complexity task elicited the highest task accomplishment ratings. Focusing on distinguishing among learner abilities, however, the highest complexity task demonstrated the best discrimination. Cognitive task complexity was also found to moderate the relationship between task accomplishment ratings and linguistic measures. Implications for research into task design, learner performance, and assessment purpose are considered.
Experimental investigations of influence on grain size and cold deformational behavior of AL6063 during the microforming process
Authors: Karthikeyan A , Rajenthirakumar D 
Published: January 2023

Abstract
Miniature products are requisite to make micro creation widely in electronics and micromechanical products. The microfabrication process is identified to satisfy the production of such miniature products rather than an ordinary manufacturing process. Microextrusion is one of the microforming processes in micromanufacturing. In this present work, an attempt has been made to investigate the influence of grain size and deformation behavior of Al6063 microstepped pin with annealed billets for the cold extrusion process. The methodology on the characterization of the microextrusion of Al6063 includes, annealing of the billet, extrusion testing, microhardness examination and surface roughness analysis. The billet with three different sizes of grains is extruded. The experimental result shows that the deformation load and average microhardness of the AA96 (annealed Al6063 with an obtained grain size of 96 μm) are high compared to AA208 (annealed Al6063 with an obtained grain size of 208 μm). The surface finish has improved using diamond-like carbon (DLC) coated die compared to uncoated and lubricated dies. DLC coating with AA208 billet achieved a maximum pin length of 13.1 mm, and uncoated die with AA96 billet achieved a minimum pin length of 5.5 mm. Thus, the findings of this study contribute to the fundamental understanding of cold microextrusion of aluminium 6063 alloy.
Methane emissions decline from reduced oil, natural gas, and refinery production during COVID-19
Authors: Thorpe A K , Kort E A , Cusworth D H , Ayasse A K , Bue B D , Yadav V , Thompson D R , Frankenberg C , Herner J , Falk M , Green R O , Miller C E , Duren R M 
Published: January 2023

Abstract
In the summer of 2020, the AVIRIS-NG airborne imaging spectrometer surveyed California’s Southern San Joaquin Valley and the South Bay (Los Angeles County) to identify anthropogenic methane (CH4) point source plumes, estimate emission rates, and attribute sources to both facilities and emission sectors. These flights were designed to revisit regions previously surveyed by the 2016–2017 California Methane Survey and to assess the socioeconomic responses of COVID-19 on emissions across multiple sectors. For regions flown by both the California Methane Survey and the California COVID campaigns, total CH4 point source emissions from the energy and oil & natural gas sectors were 34.8% lower during the summer 2020 flights, however, emission trends varied across sector. For the energy sector, there was a 28.2% decrease driven by reductions in refinery emissions consistent with a drop in production, which was offset in part with increases from powerplants. For the oil & natural gas sector, CH4 emissions declined 34.2% and significant variability was observed at the oilfield scale. Emissions declined for all but the Buena Vista and Cymric fields with an observed positive relationship between production and emissions. In addition to characterizing the short-term impact of COVID-19 on CH4 emissions, this study demonstrates the broader potential of remote sensing with sufficient sensitivity, spatial resolution, and spatio-temporal completeness to quantify changes in CH4 emissions at the scale of key sectors and facilities.
Evaluation of the impact of a pharmacist-run antimicrobial report in reducing delays in subsequent antibiotic administration in patients in the emergency department
Authors: Moynihan Meghin , Anton Greta 
Published: January 2023

Abstract

Purpose
To determine whether the implementation of a pharmacist-run, real-time electronic health record (EHR) antimicrobial report reduces the frequency of delays in subsequent antibiotic medication administration timing in patients in the emergency department (ED).

Methods
A single-center, retrospective, pre-and-post quasi-experimental study was conducted between July and December 2021 following the implementation of an antimicrobial EHR report of adult patients presenting to the ED who were continued on antibiotic therapy after receiving a one-time dose of an antibiotic in the ED. The primary objective was to determine the impact of the pharmacist-run, real-time EHR antibiotic dosing report in the ED on reducing the number of major delays in subsequent antibiotic administration times. A subanalysis of the primary outcome was performed to evaluate differences in major delays based on specific dosing intervals of 6, 8, and 12 hours.

Results
A total of 521 subsequent antibiotic dosing orders from 273 patient encounters were analyzed, with major delays in subsequent antibiotic dosing administration times identified in 20% of the intervention group compared to 27% of the control group (P = 0.047). Major delays were also significantly decreased in the intervention group compared to the control group for antibiotics dosed at 8-hour intervals (18% vs 32%; P = 0.026). No significant difference in delays was observed between the groups for antibiotics dosed at 6-hour intervals (18% vs 27%) or 12-hour intervals (29% vs 21%).

Conclusion
Implementing a real-time EHR antimicrobial report run by pharmacists in the ED was associated with significantly fewer major delays in subsequent antibiotic dosing following a first dose.
Hyper-Hamiltonian Laceability of Cartesian Products of Cycles and Paths
Authors: Yang Yuxing 
Published: January 2023

Abstract
Let $H$ be a cartesian product graph of even cycles and paths, where the first multiplier is an even cycle of length at least $4$ and the second multiplier is a path with at least two nodes or an even cycle. Then $H$ is an equitable bipartite graph, which takes the torus, the column-torus and the even $k$-ary $n$-cube as its special cases. For any node $w$ of $H$ and any two different nodes $u$ and $v$ in the partite set of $H$ not containing $w$, an algorithm was introduced to construct a hamiltonian path connecting $u$ and $v$ in $H-w$.
Atlantic salmon (Salmo salar) age at maturity is strongly affected by temperature, population and age-at-maturity genotype
Authors: Åsheim Eirik R , Debes Paul V , House Andrew , Liljeström Petra , Niemelä Petri T , Siren Jukka P , Erkinaro Jaakko , Primmer Craig R 
Published: January 2023

Abstract
Age at maturity is a key life history trait involving a trade-off between survival risk and reproductive investment, and is an important factor for population structures. In ectotherms, a warming environment may have a dramatic influence on development and life history, but this influence may differ between populations. While an increasing number of studies have examined population-dependent reactions with temperature, few have investigated this in the context of maturation timing. Atlantic salmon, a species of high conservation relevance, is a good study species for this topic as it displays considerable variation in age at maturity, of which a large proportion has been associated with a genomic region including the strong candidate gene vgll3. Until now, the effect of this gene in the context of different environments and populations has not been studied. Using a large-scale common-garden experiment, we find strong effects of temperature, population-of-origin, and vgll3 genotype on maturation in 2-year-old male Atlantic salmon (Salmo salar). With a temperature difference of 1.8°C, maturation probability was 4.8 times higher in the warm treatment than the cold treatment. This temperature effect was population-specific and was higher in the southern (60.48°N) compared to the northern (65.01°N) population. The early maturation vgll3*E allele was associated with a significantly higher maturation probability, but there was no vgll3 interaction with temperature or population. Both body condition and body mass associated with maturation. The body mass association was only present in the warm treatment. Our findings demonstrate that (i) populations can vary in their response to temperature change in terms of age at maturity, (ii) high intrinsic growth could be associated with higher thermal sensitivity for life history variation and (iii) vgll3 effects on age at maturity might be similar between populations and different thermal environments.
Impact of intra-aortic balloon counterpulsation on all-cause mortality among patients with Takotsubo syndrome complicated by cardiogenic shock: results from the German-Italian-Spanish (GEIST) registry
Authors: Santoro Francesco , Núñez Gil Iván J , Stiermaier Thomas , El-Battrawy Ibrahim , Moeller Christian , Guerra Federico , Novo Giuseppina , Arcari Luca , Musumeci Beatrice , Cacciotti Luca , Mariano Enrica , Romeo Francesco , Cannone Michele , Caldarola Pasquale , Giannini Irene , Mallardi Adriana , Leopizzi Alessandra , Vitale Enrica , Montisci Roberta , Meloni Luigi , Raimondo Pasquale , Di Biase Matteo , Almendro-Delia Manuel , Sionis Alessandro , Uribarri Aitor , Akin Ibrahim , Thiele Holger , Eitel Ingo , Brunetti Natale Daniele 
Published: January 2023

Abstract

Aims
Takotsubo syndrome (TTS) is an acute and reversible left ventricular dysfunction and can be complicated by cardiogenic shock (CS). However, few data are available on optimal care in TTS complicated by CS. Aim of this study was to evaluate short- and long-term impact of intra-aortic balloon pumping (IABP) on mortality in this setting.

Methods and results
In a multi-centre, international registry on TTS, 2248 consecutive patients were enrolled from 38 centres from Germany, Italy, and Spain. Of the 2248 patients, 212 (9.4%) experienced CS. Patients with CS had a higher prevalence of diabetes (27% vs. 19%), male sex (25% vs. 10%), and right ventricular involvement (10% vs. 5%) (P &lt; 0.01 in all cases). Forty-three patients with CS (20% of 212) received IABP within 8 h (interquartile range 4–18) after admission. No differences in terms of age, gender, cardiovascular risk factors, and admission left ventricular ejection fraction were found among patients with and without IABP. There were no significant differences in terms of 30-day mortality (16% vs. 17%, P = 0.98), length of hospitalization (18.9 vs. 16.7 days, P = 0.51), and need of invasive ventilation (35% vs. 41%, P = 0.60) among two groups: 30-day survival was not significantly different even after propensity score adjustment (log-rank P = 0.73). At 42-month follow-up, overall mortality in patients with CS and TTS was 35%, not significantly different between patients receiving IABP and not (37% vs. 35%, P = 0.72).

Conclusions
In a large multi-centre observational registry, the use of IABP was not associated with lower mortality rates at short- and long-term follow-up in patients with TTS and CS.
Beyond exercise oscillatory ventilations: the prognostic impact of loop gain in heart failure
Authors: Cunha Gonçalo J L , Maltês Sérgio , Rocha Bruno M L , Nina Duarte , Aguiar Carlos , Andrade Maria J , Moreno Luís , Durazzo Anaí , Mendes Miguel , Agostoni Piergiuseppe 
Published: January 2023

AbstractExercise oscillatory ventilation (EOV) is a strong prognostic marker in patients with heart failure (HF) and left ventricular (LV) dysfunction. This phenomenon can be explained through a single quantitative measurement of ventilatory instability, the loop gain. Therefore, we aimed to evaluate whether loop gain could be a better tool than subjective EOV evaluation to identify HF patients with a higher risk of major cardiovascular complications. This was a single-center retrospective study that included patients with left ventricular ejection fraction (LVEF) ≤ 50% consecutively referred for cardiopulmonary exercise testing (CPET) from 2016 to 2020. Loop gain was measured through computational evaluation of the minute ventilation graph. Of the 250 patients included, the 66 that presented EOV also had higher values of loop gain, when compared with patients without EOV. Those with both EOV and higher loop gain had more severe HF, with higher NT-proBNP and VE/VCO2 slope as well as lower peak VO2 and LVEF. On multivariable analysis, loop gain was strongly correlated with the composite endpoint of cardiovascular death, urgent heart transplantation, urgent left ventricular assist device implantation, or HF hospitalization, even after correcting for peak VO2, LVEF, VE/VCO2 slope, and NT-proBNP. The presence of EOV was not prognostically significant in this analysis. Loop gain is an objective parameter that quantifies ventilatory instability and showed to have a strong prognostic value in a cohort of patients with HF and LVEF ≤50%, outperforming the classification of EOV.
The Neutralisation Doctrine in EU Trade Mark Law: A Plea for Its Abolishment
Authors: Vrielink Jesper , Torenbosch Jorn 
Published: January 2023

Abstract
This article focuses on the neutralisation doctrine established by the Court of Justice of the European Union in its Picasso/Picaro ruling. This doctrine stipulates that visual and/or phonetic similarity of conflicting signs can be neutralised by a conceptual difference between the signs if one of those signs has a clear and specific meaning which can be grasped immediately by the public. We trace the origin of the neutralisation doctrine as well as the manner in which the neutralisation doctrine has developed over the years. We then assess the position of the neutralisation doctrine in the broader phased assessment of similarity established by the Court of Justice of the European Union in EUIPO/Equivalenza Manufactory. We express our objections against the neutralisation doctrine and argue for its abolishment. In our view, the test of whether the public perceives a sign as referring to a trade mark which identifies goods or services or as a word or famous person is in essence a test of the distinctive character of that sign. In our concluding remarks, we argue once more for the abolishment of the neutralisation doctrine and provide some practical guidance to minimise its effects as long as it remains established law.