bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unusual presentation of Lewis-Sumner Syndrome in elderly
Authors: Sarraj Rihab , Brahem Mouna , Abid Hayfa , Jomaa Olfa , Ardhaoui Mahbouba , Abdellatif Sirine , Younes Mohamed 
Published: January 2025

Abstract

Lewis-Sumner Syndrome (LSS) is a rare disease that affect usually young adult. It is characterized by a proximal and especially distal myalgia, asymmetric muscle weakness, which mostly affects the upper limbs with early onset. Diagnosis can be difficult to establish if the clinical presentation is atypical. We report here a rare case of LSS in an old patient with unusual clinical aspects. A 70-year-old female patient with a history of atrial fibrillation complicated by pulmonary embolism, presented with myalgia and muscle weakness of the shoulders, upper arms, hips and thighs. This involvement was bilateral, symmetrical and evolving for 3 months, causing difficulties in climbing stairs, standing or walking. Physical examination showed a proximal muscle deficiency affecting proximal muscles of the upper and lower limbs. In this stage, we suspected an inflammatory myopathy or polymyalgia rheumatica. Biological investigation showed an inflammatory syndrome and an elevated lactate dehydrogenase level. The immunoblot polymyositis profile was negative. Magnetic Resonance Imaging (MRI) of hips revealed a signal abnormality in the gluteus medius muscles on both sides with inflammatory appearance. The Electromyography revealed sensorimotor neuropathy affecting the four limbs more pronounced in lower ones, with motor nerve conduction blocks. The cerebrospinal fluid study revealed a proteinorachia at 0.4g/l with normal glycorachia and normal cell counts. These results confirmed the diagnosis of LSS. The patient was treated by corticosteroids at dose of 1 mg/ kg/ day during 2 months, with a progressive decrease of treatment. The evolution was marked by spectacular clinical and biological relief.
“We’ve lost a lot of lives:” The Impact of the Closure of North America’s Busiest Supervised Consumption Site on People Who Use Substances and the Organizations that Work with Them
Authors: Magnuson Morgan , Vandenberg Shannon , Oosterbroek Tracy , Dey Kevin 
Published: January 2025

Abstract

Background
Supervised Consumption Sites (SCSs) are an evidence-based harm reduction strategy to reduce the risk of fatal drug poisonings. However, this approach has faced political opposition in Canada, resulting in the closures of SCSs in some provinces. Our study aims to add to the understanding of the impact of SCS closures by exploring the perspectives of both people who use substances (PWUS) and the staff members of organizations that continue to provide harm reduction services. Our study explores the aftermath of the closure of what was once North America’s busiest SCS, located in Lethbridge, Alberta, Canada, offering a contextualized exploration of regressive harm reduction policies.
Methods
To better understand the impact of the closure, our study adopts a descriptive qualitative design to explore this novel phenomenon within the unique context of Lethbridge, Alberta. We conducted 27 interviews with PWUS and 10 with Staff Members of organizations that provide harm-reduction services. We chose to use reflexive thematic analysis (TA), which allows for a critical realist and contextual approach to data analysis.
Results
We developed three themes based on our analysis. Our first theme speaks to the harms of SCS closures on PWUS and organizations that provide harm reduction services. Next, our second theme highlights the perspectives of participants on the political motivations behind the ARCHES closure. Our last theme explores how PWUS and organizations navigate the political opposition to harm reduction approaches while responding to the worsening drug poisoning crisis.
Conclusions
Our study highlights the continued need to expand harm reduction services and for ongoing advocacy to reverse regressive policy decisions.
Features of intestinal microbiota composition in cancer patients
Authors: Aginova V. V. , Grigorievskaya Z. V. , Petukhova I. N. , Bagirova N. S. , Tereshchenko I. V. , Samoylenko I. V. , Kuzmenko A. O. , Kononets P. V. 
Published: January 2025

Objective: to evaluate and compare the qualitative and quantitative composition of the intestinal microbiota in patients with malignant neoplasms of various localizations. Material and Methods. The study included patients who received different types of treatment in N.N. Blokhin Oncology Research Center, Moscow, Russia in 2023 for gastric cancer, including cardioesophageal adenocarcinoma (group 1), esophageal squamous cell carcinoma (group 2) and metastatic or locally advanced melanoma of the skin (group 3). All patients had to have morphologic verification of the diagnosis at the time of inclusion, be over 18 years old, have an ECOG performance status of ≤1, and have no evidence of intestinal infection, as well as not take antibiotics within 28 days prior to entry into the study. Stool samples were collected during patients’ hospitalization. The quantitative and qualitative composition of microorganisms of 17 taxonomic groups was evaluated. Microorganisms were cultured according to standard microbiological methods, taking into account the growth conditions of a particular group of microorganisms. Species identification of microbial isolates was obtained by matrix-assisted laser desorption/ionization-time-of-flight mass spectrometry (MALDI-TOF) and MALDI Biotyper v.3.0 software (Bruker daltonics, Germany). Descriptive statistics methods from the SPSS Statistics, v.27 software package were used. To quantitatively describe the species diversity of the gut microbiota, calculations were performed using the Margalef species richness index (d) and Shannon’s (H) diversity index. The criterion of uniformity of microbial species distribution according to their abundance in the population community was evaluated using the Pielow index (E). The Hutcheson’s T-criterion was used to test the significance of differences between sample sets of Shannon index values and to obtain statistically correct estimates of differences (p≤0.05). Results. A total of 63 samples of biological material (feces) were investigated. A change in the quantitative composition of intestinal microbiota in all study groups was found, which may have a negative impact on the general condition of the patient and the effectiveness of antitumor treatment. The increase in the proportion of Proteobacteria (Enterobacterales) can be considered as a risk factor for the development of infectious complications caused by Gram-negative microorganisms. The analysis of factors influencing the taxonomic diversity of intestinal microbiota revealed no significant differences in the composition of intestinal microbiota between the groups of patients with malignant tumors of different nosological forms (p>0.05).
Facile Synthesis of Monodisperse Gold Nanorods, Gold Nanobipyramids and Gold Nanocups with Different Coatings and Evaluation of Their Cellular Cytotoxicity
Authors: Zuo Fanjiao , Zhou Shuting , Wu Xiwei , Wang Boyao , He Jun , Qiu Xilong 
Published: January 2025

Introduction:
Assessing the cytotoxicity of gold nanoparticles (GNPs) has gained importance
due to their development in the biomedical field.

Method:
In this study, we systematically synthesized gold nanorods (GNRs), gold nanobipyramids
(GNBPs), and gold nanocups (GNCs) using a seed-mediated method, with an average length of 32.53
± 4.67 nm, 72.90 ± 7.54 nm and 118.01 ± 11.02 nm, respectively.

Results:
Furthermore, using the cell counting kit-8 (CCK-8) assay, we assessed the cellular cytotoxicity
of three different types of GNPs with various different surface coatings, such as organic
cetyltrimethylammonium bromide (CTAB) and polyethylene glycol (PEG). The results showed that
the cytotoxic behavior of GNPs was shape-dependent in the concentration range of 3.125 -100
μg/mL. The types of GNPs and their surface coating had a significant impact on how the GNPs behaved
in cells. Compared to PEG-coated GNPs, which do not induce cell injury, CTAB-coated GNPs
show more noticeable cytotoxicity.

Conclusion:
Furthermore, compared to GNCs, the toxicity of GNRs and GNBPs against GES-1
cells, RAW 264.7 cells and LX-2 cells was greater. Our research provides an important new understanding
of the effects of surface modification on the biocompatibility and the shape of GNPs in the
biomedical field.
Current Applications and Future Directions for Vascular Stents with Stem Cells in the Treatment of Intracranial Aneurysms: A Mini-Review
Authors: Chattopadhyay Kaustav , Sreenivasan Sanjeev , Gupta Gaurav , Abramyan Arevik , Zotarelli Filho Idiberto Jose , Sundararajan Srihari , Nanda Anil , Roychowdhury Sudipta 
Published: January 2025

Abstract:
Vascular stents and stem cells have been used in high-acuity cases for many decades,
particularly in cardiology. Providing the physician with another avenue of treatment, they have
had a reasonable amount of success. However, there has been very little research conducted on
seeding vascular stents with stem cells when treating intracranial aneurysms. Our work aims to understand
the current literature available on the viability of such stents and the future directions one
should take when choosing stents seeded with stem cells. Three computerized searches in
PubMed were used. Four papers met the criteria, and two were excluded. There have been some
experiments where the efficacy of vascular stents seeded with different materials was tested. G/PLL-
coated stents provided multiple advantages and bioactive benefits to the mesenchymal stem
cells. On the other hand, SF/SDF-1α also promoted similar benefits but provoked multiple unwanted
inflammatory responses. G/PLL and SF/SDF-1α coated stents were able to provide satisfactory
results but still require more extensive research to thoroughly understand their efficacies and safety.
Future directions may include researching and discovering a wider array of biocompatible materials
to seed the stents.
Associations of Chronic Hepatitis B and Nonalcoholic Fatty Liver Diseases with New-Onset Metabolic Syndrome in Military Personnel before Midlife: A Cohort Study
Authors: Tsai Kun-Zhe , Liu Pang-Yen , Lin Yen-Chen , Huang Chen-Ming , Wang Hui-Shang , Lin Gen-Min 
Published: January 2025

Background:
Hepatic inflammation, e.g., Nonalcoholic Fatty Liver Diseases (NAFLD)
and the severe form of steatohepatitis (NASH), has been associated with a higher risk of MetS in
the general population.

Aims:
This study aimed to investigate the associations of chronic hepatitis B (CHB) and fatty liver
diseases with the incidence of metabolic syndrome (MetS) in young adults, which have not been
verified before.

Objective:
The associations between NAFLD, NASH, and CHB and the incidence of new-onset
MetS remain inconclusive in young adults.

Methods:
This cohort study included 2,614 military personnel aged 18-39 years who were free of
baseline MetS in 2014 and were followed for the incidence of MetS in each annual health examination
until the end of 2020. CHB was defined by the presence of the hepatitis B surface antigen
with an established diagnosis history. NAFLD and NASH were defined by the ultrasound finding
with an elevated alanine transaminase (27–53.9 and ≥54 U/L in men and 15–29.9 and ≥30 U/L in
women, respectively). MetS was defined based on the International Diabetes Federation criteria.
Multivariable Cox regression analysis was used to determine the associations between hepatitis
and incident MetS.

Results:
During a mean follow-up of 6.0 years, 582 new-onset MetS cases occurred (22.3%).
NAFLD and NASH were associated with a greater risk of new-onset MetS (hazard ratios (HRs)
and 95% confidence intervals: 1.47 (1.21-1.79) and 1.66 (1.16-2.39), respectively), while no association
for CHB was found (HR: 1.31 (0.88-1.96)).

Conclusion:
This study found that NAFLD and NASH, while not CHB, were independent risk factors
of new-onset MetS with adjustments for potential covariates, e.g., physical activity and fitness
in young adults.
Real-World Insights Into Dementia Diagnosis Trajectory and Clinical Practice Patterns Unveiled by Natural Language Processing: Development and Usability Study
Authors: Paek Hunki , Fortinsky Richard H , Lee Kyeryoung , Huang Liang-Chin , Maghaydah Yazeed S , Kuchel George A , Wang Xiaoyan 
Published: January 2025

Abstract

Background
Understanding the dementia disease trajectory and clinical practice patterns in outpatient settings is vital for effective management. Knowledge about the path from initial memory loss complaints to dementia diagnosis remains limited.

Objective
This study aims to (1) determine the time intervals between initial memory loss complaints and dementia diagnosis in outpatient care, (2) assess the proportion of patients receiving cognition-enhancing medication prior to dementia diagnosis, and (3) identify patient and provider characteristics that influence the time between memory complaints and diagnosis and the prescription of cognition-enhancing medication.

Methods
This retrospective cohort study used a large outpatient electronic health record (EHR) database from the University of Connecticut Health Center, covering 2010‐2018, with a cohort of 581 outpatients. We used a customized deep learning–based natural language processing (NLP) pipeline to extract clinical information from EHR data, focusing on cognition-related symptoms, primary caregiver relation, and medication usage. We applied descriptive statistics, linear, and logistic regression for analysis.

Results
The NLP pipeline showed precision, recall, and F1-scores of 0.97, 0.93, and 0.95, respectively. The median time from the first memory loss complaint to dementia diagnosis was 342 (IQR 200-675) days. Factors such as the location of initial complaints and diagnosis and primary caregiver relationships significantly affected this interval. Around 25.1% (146/581) of patients were prescribed cognition-enhancing medication before diagnosis, with the number of complaints influencing medication usage.

Conclusions
Our NLP-guided analysis provided insights into the clinical pathways from memory complaints to dementia diagnosis and medication practices, which can enhance patient care and decision-making in outpatient settings.
PANDAWA: Inovasi Dinas Kependudukan dan Pencatatan Sipil Kabupaten Pasaman Barat dalam Memberikan Pelayanan Administrasi Kependudukan
Authors: Alifya Falina , Ariany Ria , Ekha Putera Roni 
Published: January 2025

Quality public services are the hope of every society. Therefor, the West Pasaman Regency Population and Civil Registration Service strives to provide the best service through various service innovations, one of which is PANDAWA. PANDAWA is a digital innovation in providing population administration service via whatsapp so that people can access service online by sending massage to the PANDAWA whatsapp number. The research aims to analyze the attributes of PANDAWA innovation in providing public services. This research was elaborated using Evereet Rogers theory about innovation atributes . This research uses descriptive qualitative research methods. Meanwhile for data collection, researchers used three methods namely interviews, documentation, and observation. The research results obtained are that PANDAWA innovation provides benefits both in term of time and cost for community. This innovation is also relevant to the vision and mission of West Pasaman Regency and is ini accordance with previous innovations, namely DPM. As an innovation PANDAWA is generally not complicated to access, but there several types of service that require downloading a form as a requirement. Than, PANDAWA has also gone through a trial process and is easy information PANDAWA related to can be seen on the West Pasaman Disdukcapil Disdukcapil’s instagram, facebook, but teh available information is not update.
Implementasi Kode Etik Mahasiswa dalam Berbusana di Fakultas Ekonomi dan Ilmu Sosial Universitas Islam Negeri Sultan Syarif Kasim Riau
Authors: Rahmadani Suci , Wahyudi Rodi 
Published: January 2025

This research aims to determine the implementation of the student code of ethics in dressing at the Faculty of Economics and Social Sciences, Sultan Syarif Kasim State Islamic University, Riau. This research uses a qualitative method with a descriptive approach which is strengthened by the results of interviews. The research results show that female students have received socialization about the dress code of ethics from lecturers when they first entered campus. The dress code of ethics that is most often violated by female students is tucking their clothes into their skirts. The parties who often reprimand students who violate the dress code of ethics are lecturers. Female students who violate the dress code of ethics still do not receive strict sanctions because they still take the form of a verbal warning and are told to go home to change clothes according to the code of ethics.
Utilisation de produits de vapotage contenant de la nicotine lors d’une tentative d’abandon du tabagisme par des adultes canadiens fumeurs ou ayant récemment cessé de fumer : résultats concernant le Canada tirés de l’Enquête sur le tabagisme et le vapotage dans quatre pays menée en 2022 par le Projet international d’évaluation de la lutte antitabac
Authors: Gravely Shannon , Sweanor David , Driezen Pete , Levy David T. , Fong Geoffrey T. , Quah Anne C. K. , Craig Lorraine V. , Chung-Hall Janet , Kaai Susan C. , Cummings K. Michael 
Published: January 2025

Abstract

Nous avons mené une analyse portant sur 1 771 adultes canadiens qui fument ou fumaient des cigarettes en nous fondant sur les données de l’Enquête sur le tabagisme et le vapotage dans quatre pays menée en 2022 par le Projet international d’évaluation de la lutte antitabac. En utilisant des données pondérées, nous avons estimé la prévalence des tentatives d’abandon du tabagisme chez les adultes canadiens entre 2020 et 2022 et nous avons évalué leur utilisation d’un produit de vapotage contenant de la nicotine (PVN), de même que les arômes et les dispositifs le plus souvent utilisés lors de leur tentative d’abandon la plus récente. Dans l’ensemble, 36,5 % des participants ont tenté de cesser de fumer et 19,4 % de ces derniers ont utilisé un PVN. Ceux qui étaient plus jeunes et qui avaient effectivement cessé de fumer étaient plus susceptibles d’avoir utilisé un PVN. Les cartouches ou capsules (pods) préremplies (36,3 %) et les arômes de fruits (39,5 %) étaient les choix les plus populaires.
Chinatown in Madura as urban heritage branding: Potential and challenges
Authors: Rakhmawati Yuliana , Silviana Rizka Dian , Wijayani Qoniah Nur 
Published: January 2025

Background: Chinatowns have become popular tourist destinations in various prominent locations worldwide. Similarly, several Chinatowns around the cities in Indonesia, including Bangkalan in Madura, can potentially be developed as an attractive tourist destination. Purpose: This study explored the potential of Chinatown to grow as a city branding tourism in Bangkalan. Methods: It employed a qualitative descriptive method to understand the potential and obstacles to developing Chinatown in Bangkalan, Madura. Data was collected using open-ended interviews, semi-participatory observation, and related documentation. Informants comprised local Chinatown residents, cultural observers, tourism agents, and local government authorities or regulators. Spradley’s taxonomic analysis was used to map findings into thematic categories. Triangulation and observation persistence were used as techniques to ensure the data validity. Results: Based on the destination branding theory and SWOT analysis, Chinatown in Bangkalan has strength in accessibility, supporting facilities, heritage buildings, and Madurese Chinese culture. Meanwhile, weaknesses were found in regulation and coordination among the parties involved. Conclusion: Chinatown in Bangkalan can potentially be developed as an urban heritage branding by harnessing accessibility, supporting facilities, and heritage buildings while simultaneously mitigating the barriers. Implications: The research results can be a guide for policy brief formulation and insights for related stakeholders. Subsequent research can further explore the perceptions of Chinatown tourism enthusiasts from a diverse demographic perspective.
Microemulsions and Nanoparticles: The Sustainable Future of Drilling Fluids in Oil Exploration
Authors: Queiroz Neto José Cavalcante de , Remboski Thiago Alves , Leal Giovanna Laís Rodrigues , Pessoa Maria Eduarda Araújo , Freitas Júlio Cézar de Oliveira , Curbelo Fabiola Dias da Silva 
Published: January 2025

Objective: This study aims to contextualize the advancements in the application of nanoparticles, microemulsions, and nanoemulsions in drilling fluids, highlighting their contributions to the efficiency and sustainability of operations in the oil industry.

Theoretical Framework: The research is grounded in principles of nanotechnology and fluid dynamics, analyzing the role of drilling fluids in aspects such as wellbore instability, rheological properties, filtration, and physicochemical characteristics.

Method: A systematic literature review was conducted, encompassing scientific articles, conference papers, technical books, and patents. The research included both foundational and recent studies to identify trends and advancements in drilling fluid formulations.

Results and Discussion: Drilling fluid formulations have evolved to address challenges such as diverse well geometries, extreme temperature and pressure gradients, and environmental regulations. The incorporation of nanoparticles into drilling fluids has demonstrated benefits such as reduced circulation losses and increased resistance to high pressures and temperatures. Nanoemulsions and microemulsions have shown reduced environmental impact compared to oil-based fluids, along with improved filtration properties, rheology, and thermal resistance compared to water-based fluids.

Research Implications: The findings underscore the importance of nanoparticles and nanoemulsion and microemulsion systems for enhancing the efficiency and sustainability of drilling fluids, meeting the demand for environmentally responsible solutions.

Originality/Value: This study provides a comprehensive analysis of advancements in drilling fluid formulations, emphasizing the sustainable potential of nanoparticles, nanoemulsions, and microemulsions, and reinforcing their relevance to the future of the oil industry.
Features and regulation of the use of distributed ledger technology
Authors: Rizvanova I. A. , Belova M. T. 
Published: January 2025

As a result of the conducted research, it has been revealed that the scientific and practical literature lacks sufficient studying of the functioning and systematisation of existing data on new financial technologies, on the basis of which modern financial services and products are developed. There-fore, the features of distributed ledger technology (hereinafter referred to as DLT) are chosen as the subject of research in this work. The purpose of the study is to analyse the application of the DLT in modern conditions based on exploring theoretical and practical aspects of the problem under study. In accordance with the set purpose, the objectives are to identify the features of the DLT, to develop a classification of this technology according to appropriate criteria as well as to identify the directions of regulating the use of the DLT in modern conditions. The sources of information are informational and analytical materials and empirical data from open sources of both public authorities and commercial organisations. In the course of the study, the features of the DLT are considered, the criteria for its classification are presented as well. Based on the results of the conducted study, it has been concluded that the features of the DLT described by us are fragmentary reflected in regulatory legal acts, which once again emphasises the need to develop common guidelines for public policy in relation to the legal and technical regulation of the DLT in Russia.