bluuebunny/crossref_metadata_2025_split huggingface dataset:
Alcohol Use and Mortality Among Older Couples in the United States: Evidence of Individual and Partner Effects
Authors: Birditt Kira S , Turkelson Angela , Polenick Courtney A , Cranford James A , Smith Jennifer A , Ware Erin B , Blow Frederic C 
Published: July 2023

Abstract

Background and Objectives
Spouses with concordant (i.e., similar) drinking behaviors often report better quality marriages and are married longer compared with those who report discordant drinking behaviors. Less is known regarding whether concordant or discordant patterns have implications for health, as couples grow older. The present study examined whether drinking patterns among older couples are associated with mortality over time.

Research Design and Methods
The Health and Retirement Study (HRS) is a nationally representative sample of individuals and their partners (married/cohabiting) over age 50 in the United States, in which participants completed surveys every 2 years. Participants included 4,656 married/cohabiting different-sex couples (9,312 individuals) who completed at least 3 waves of the HRS from 1996 to 2016. Participants reported whether they drank alcohol at all in the last 3 months, and if so, the average amount they drank per week. Mortality data were from 2016.

Results
Analyses revealed concordant drinking spouses (both indicated they drank in the last 3 months) survived longer than discordant drinking spouses (1 partner drinks and the other does not) and concordant nondrinking spouses. Analysis of average drinks per week showed a quadratic association with mortality such that light drinking predicted better survival rates among individuals and their partners compared with abstaining and heavy drinking. Further, similar levels of drinking in terms of the amount of drinking were associated with greater survival, particularly among wives.

Discussion and Implications
This study moves the field forward by showing that survival varies as a function of one’s own and one’s partner’s drinking.
Caregiving Among Older Black Same-Gender-Loving Women During the COVID-19 Pandemic: Findings From Qualitative Research
Authors: Poteat Tonia , Hall Porsha , Adams Mary Anne , Gautam Dipa Sharma , Ashenden Robynn , Horn Jennifer 
Published: July 2023

Abstract

Background and Objectives
Few data on caregiving during the coronavirus disease 2019 pandemic use an intersectional lens to attend to how multiple social categories, such as gender, age, race, and sexual orientation, shape caregiving experiences. This analysis sought to explore caregiving experiences of aging Black same-gender-loving women.

Research Design and Methods
Sixteen focus groups were conducted with 4–8 participants each (N = 102) from across the United States. Audio-recorded discussions lasted for approximately 90 min and were transcribed verbatim. Two analysts coded transcripts for discussions related to caregiving and used content analysis to identify themes.

Results
Participants engaged in caregiving for children, parents, family, friends, and neighbors. They provided physical, economical, instrumental, and/or secondary caregiving; and sometimes received care themselves. The pandemic heavily affected their stress level and mental health as well as their intimate partner relationships. Discussions mostly offered descriptions of increased caregiving difficulty caused by the pandemic. However, a few participants identified ways the pandemic made caregiving easier; changed caregiving without making it easier or harder; or thwarted their ability to provide care.

Discussion and Implications
Older Black same-gender-loving women described some pandemic caregiving experiences that diverged from the existing literature, demonstrating the importance of considering how gender, race, age, and sexual orientation affect caregiving experiences during a pandemic fraught with health inequities. Ensuring the multiply marginalized caregivers have access to the practical and emotional support they need is critical for advancing health equity and preparing for future pandemics.
Crustal structure beneath and surrounding the Appalachian Basin region of Eastern North America imaged by joint inversion of P wave receiver functions and surface wave dispersion measurements
Authors: Homman Kyle , Nyblade Andrew 
Published: July 2023

SUMMARY
To evaluate the plate flexure model for the formation of the Appalachian Basin, we investigate the extent to which crustal structure beneath and surrounding the basin was modified by the Palaeozoic orogenic events that created the basin. We jointly invert receiver functions and surface wave dispersion measurements to obtain 1-D crustal Vs profiles for 261 seismic stations located within and around the basin. The average crustal thickness for the region is 44 km, and the crust gradually thins to the east, consistent with previous studies. Four areas of anomalous crust are identified with respect to the eastward thinning of the crust. An area of thick crust is found along the Grenville Front on the western side of the Appalachian Basin where the crust thickens by ∼5–10 km. Moho depths of up to 54 km in this region likely result from suture-thickening. The crust is thinner beneath the Neoproterozoic Scranton rift by ∼5–7 km, coincident with a ∼40 mGal Bouguer gravity high. Across the Neoproterozoic Rome Trough, the crust thins by ∼4–5 km, coincident with a ∼10 mGal Bouguer gravity high. Density models for these rifts show that the rift-related crustal thinning is sufficient to explain the gravity anomalies. The Vs models obtained for stations in the rifts indicate little, if any, mafic layering in the mid-crust and only a modest amount of mafic layering in the lower crust. In the northwestern portion of the Appalachian Basin in northeastern Ohio and northwestern Pennsylvania within the Elzevir block, another area of anomalously thick crust (50–52 km) is found. This region is not associated with any known tectonic structures or boundaries or a gravity anomaly. The lower ∼5–10 km of the crust in this region is characterized by high (&gt;3.9 km s−1) shear wave velocities and thus appears to be mafic. The origin of anomalous crustal structure in all four areas is best attributed to Precambrian tectonic events that predate the formation of the Appalachian Basin, indicating that the crystalline crust beneath and surrounding the basin was not significantly affected by the Palaeozoic basin-forming orogenic events, a finding which supports the use of plate flexure models for understanding basin formation.
Tracking aftershock sequences using empirical matched field processing
Authors: Kværna T , Harris D B , Näsholm S P , Köhler A , Gibbons S J 
Published: July 2023

SUMMARY
Extensive aftershock sequences present a significant problem to seismological data centres attempting to produce near real-time comprehensive seismic event bulletins. An elevated number of events to process and poorer performance of automatic phase association algorithms can lead to large delays in processing and a greatly increased human workload. Global monitoring is often performed using seismic array stations at considerable distances from the events involved. Empirical matched field processing (EMFP) is a narrow-frequency band array signal processing technique that recognizes the inter-sensor phase and amplitude relations associated with wavefronts approaching a sensor array from a given direction. We demonstrate that EMFP, using a template obtained from the first P arrival from the main shock alone, can efficiently detect and identify P arrivals on that array from subsequent events in the aftershock zone with exceptionally few false alarms (signals from other sources). The empirical wavefield template encodes all the narrow-band phase and amplitude relations observed for the main shock signal. These relations are also often robust and repeatable characteristics of signals from nearby events. The EMFP detection statistic compares the phase and amplitude relations at a given time in the incoming data stream with those for the template and is sensitive to very short-duration signals with the required characteristics. Significant deviations from the plane wavefront model that typically degrade the performance of standard beamforming techniques can enhance signal characterization using EMFP. Waveform correlation techniques typically perform poorly for aftershocks from large earthquakes due to the distances between hypocentres and the wide range of event magnitudes and source mechanisms. EMFP on remote seismic arrays mitigates these difficulties; the narrow-band nature of the procedure makes arrival identification less sensitive to the signals’ temporal form and spectral content. The empirical steering vectors derived for the main shock P arrival can reduce the frequency dependency of the slowness vector estimates. This property helps us to automatically screen out arrivals from outside of the aftershock zone. Standard array processing pipelines could be enhanced by including both plane-wave and empirical matched field steering vectors. This would maintain present capability for the plane-wave steering vectors and provide increased sensitivity and resolution for those sources for which we have empirical calibrations.
Identification of potential classes of glycoligands mediating dynamic endothelial adhesion of human tumor cells
Authors: Starzonek Sarah , Maar Hanna , Mereiter Stefan , Freytag Vera , Haider Marie-Therese , Riecken Kristoffer , Huang Yen-Lin , Jacob Francis , Wicklein Daniel , Schumacher Udo , Lange Tobias 
Published: July 2023

Abstract
One critical step of metastasis formation is the extravasation of circulating tumor cells from the bloodstream. This process requires the dynamic interaction of cell adhesion molecules like E-selectin on endothelial cells with carbohydrate ligands on tumor cells. To characterize these glycans in a comprehensible approach, the rolling, tethering, and firm adhesion of nine human tumor cell lines on human umbilical vein endothelial cells was analyzed using laminar flow adhesion assays. The tumor cell lines were grouped into three subsets by their canonical E-selectin ligand status (sialyl-Lewis A and X +/+, −/+, −/−) and their adhesiveness was compared after enzymatic, pharmacologic, chemical treatment or antibody blockade of the tumor cells or endothelial cells, respectively. Tumor cells were also screened regarding their glycosyltransferase expression profile. We found that although E-selectin and terminal α2,3-sialic acid largely determined firm adhesion, adhesive events did not exclusively depend on the presence of sialyl-Lewis A and/or sialyl-Lewis X. Nevertheless, two of the three sialyl-Lewis A/X−/− tumor cells additionally or fully depended on vascular cell adhesion molecule-1 for firm adhesion. The significance of O-GalNAc- and N-glycans for adhesion varied remarkably among the tumor cells. The sialyl-Lewis A/X+/+ subset showed glycoprotein-independent adhesion, suggesting a role of glycolipids as well. All sialyl-Lewis A/X−/− tumor cells lacked FUT3 and FUT7 expression as opposed to sialyl-Lewis A/X+/+ or −/+ cell lines. In summary, the glycans on tumor cells mediating endothelial adhesion are not as much restricted to sialyl-Lewis A /X as previously assumed. The present study specifically suggests α2,3-linked sialic acid, O-GalNAc glycans, glycosphingolipids, and FUT3/FUT7 products as promising targets for future studies.
Sensory Mechanisms of Parent-Offspring Recognition in Fishes, Amphibians, and Reptiles
Authors: Ray Emily J , Maruska Karen P 
Published: July 2023

Synopsis
Parental care is important for offspring survival and success. Recognition of offspring by parents is critical to ensure parents direct care behaviors at related offspring and minimize energy lost by caring for unrelated young. Offspring recognition of parents prevents possible aggressive interactions between young and unrelated adults and allows offspring to direct begging behaviors toward the correct adult. Despite its importance and widespread nature, much of the current research has focused on a small range of species, particularly mammals and birds. We review the existing literature on the sensory mechanisms of parent-offspring recognition in fishes, amphibians, and reptiles. Within these groups, there is diversity in the presence and strategies for parent-offspring recognition. Future studies should continue to identify these mechanisms, as well as the neural and endocrine underpinnings in non-model organisms to expand our knowledge of this behavior and inform our understanding of the evolution of parent-offspring recognition.
Ventral Hippocampal Input to Infralimbic Cortex Is Necessary for the Therapeutic-Like Effects of Extinction in Stressed Rats
Authors: Paredes Denisse , Morilak David A 
Published: July 2023

Abstract

Background
Posttraumatic stress disorder is characterized by deficits in cognitive flexibility related to dysfunction of the medial prefrontal cortex (mPFC). Exposure therapy can effectively reverse these deficits. Fear extinction in rodents bears similarity to exposure therapy. Extinction reverses chronic stress–induced deficits in cognitive flexibility on the attentional set-shifting test (AST), an mPFC-mediated process. This therapeutic effect requires activity of pyramidal neurons and brain derived neurotrophic factor (BDNF) signaling in infralimbic cortex (IL). However, the circuit mechanisms governing BDNF-mediated plasticity initiated by extinction in IL are unknown. The ventral hippocampus (vHipp) plays a role in regulating IL activity during extinction, and plasticity in vHipp is necessary for extinction memory consolidation. Therefore, we investigated the role of vHipp input to IL in the effects of extinction in reversing stress-induced cognitive deficits.

Methods
vHipp input to IL was silenced using a Gi-Designer Receptors Exclusively Activated by Designer Drugs (DREADD) via local infusion of clozapine-N-oxide (CNO) into IL before extinction. A day later, rats were tested on AST. In a separate experiment, we tested whether vHipp input to the IL induces BDNF signaling to exert therapeutic effects. We activated the vHipp using a Gq-DREADD, and injected an anti-BDNF neutralizing antibody into IL. Rats were tested on the AST 24 hours later.

Results
Silencing the vHipp input to IL prevented the beneficial effects of extinction in reversing stress-induced cognitive deficits. Activating vHipp input to IL in the absence of extinction was sufficient to reverse stress-induced deficits in set-shifting. The beneficial effects were blocked by local infusion of a neutralizing anti-BDNF antibody into IL.

Conclusions
vHipp-driven BDNF signaling in IL is critical for extinction to counteract the deleterious cognitive effects of chronic stress.
Discovery and structural assignment of (S)-sydosine from amphipod-derived Aspergillus sydowii MBC15-11F through HRMS, advanced Mosher, and molecular modelling analyses
Authors: Qader Mallique , Mweetwa Larry L , Rämä Teppo , Thissera Bathini , Milne Bruce F , Abdelmohsen Usama R , Orfali Raha , Tawfike Ahmed , Esheli Manal , Oluwabusola Emmanuel T , Jaysainghe Lalith , Jaspars Marcel , Rateb Mostafa E 
Published: July 2023

Abstract

Aims
This study aims to prioritize fungal strains recovered from under-explored habitats that produce new metabolites. HRMS dereplication is used to avoid structure redundancy, and molecular modelling is used to assign absolute configuration.

Methods and results
MBC15-11F was isolated from an amphipod and identified using ITS, 28S, and β-tubulin phylogeny as Aspergillus sydowii. Chemical profiling using taxonomic-based dereplication identified structurally diverse metabolites, including unreported ones. Large-scale fermentation led to the discovery of a new N-acyl adenosine derivative: (S)-sydosine (1) which was elucidated by NMR and HRESIMS analyses. Two known compounds were also identified as predicted by the initial dereplication process. Due to scarcity of 1, molecular modelling was used to assign its absolute configuration without hydrolysis, and is supported by advanced Mosher derivatization. When the isolated compounds were assessed against a panel of bacterial pathogens, only phenamide (3) showed anti-Staphylococcus aureus activity.

Conclusion
Fermentation of A. sydowii yielded a new (S)-sydosine and known metabolites as predicted by HRESIMS-aided dereplication. Molecular modelling prediction of the absolute configuration of 1 agreed with advanced Mosher analysis.
Differential evolution algorithm with improved crossover operation for combined heat and power economic dynamic dispatch problem with wind power
Authors: Li Mengdi , Zou Dexuan , Ouyang Haibin 
Published: July 2023

Abstract
This paper proposes a differential evolution algorithm with improved crossover operation (ICRDE) to deal with combined heat and power dynamic economic dispatch (CHPDED) problems with wind power. First, the improved crossover operation is used to maintain the population diversity by using original individuals, first mutated individuals, and second mutated individuals. Second, the scaling factor and weighted factor are incorporated into the mutation operation to improve the convergence efficiency of the algorithm. Third, adaptive control parameters are introduced to balance local exploitation and global exploration. Moreover, after being updated by the mutation and crossover operation of ICRDE at each generation, the solutions of ICRDE will be further amended using a constraint handling method, which improves the chance of acquiring feasible solutions. Experimental results demonstrate that ICRDE has strong global optimization ability and surpasses the compared algorithms for the CEC2017 benchmark functions, the combined heat and power economic dispatch problems, and the CHPDED problem with and without wind power.
Quantum-inspired African vultures optimization algorithm with elite mutation strategy for production scheduling problems
Authors: Liu Bo , Zhou Yongquan , Luo Qifang , Huang Huajuan 
Published: July 2023

Abstract
The production scheduling (PS) problem is a challenging task that involves assigning manufacturing resources to jobs while ensuring that all constraints are satisfied. The key difficulty in PS is determining the appropriate order of operations. In this study, we propose a novel optimization algorithm called the quantum-inspired African vultures optimization algorithm with an elite mutation strategy (QEMAVOA) to address this issue. QEMAVOA is an enhanced version of the African vulture optimization algorithm that incorporates three new improvement strategies. Firstly, to enhance QEMAVOA’s diversification ability, the population diversity is enriched by the introduction of quantum double-chain encoding in the initialization phase of QEMAVOA. Secondly, the implementation of the quantum rotating gate will balance QEMAVOA’s diversification and exploitation capabilities, leading the vulture to a better solution. Finally, with the purpose of improving the exploitability of QEMAVOA, the elite mutation strategy is introduced. To evaluate the performance of QEMAVOA, we apply it to two benchmark scheduling problems: flexible job shop scheduling problem and parallel machine scheduling. The results are compared to those of existing algorithms in the literature. The test results reveal that QEMAVOA surpasses comparison algorithms in accuracy, stability, and speed of convergence.
Source-independent least-squares reverse time migration in vertical transversely isotropic media based on the Student’s t-distribution
Authors: Ye Zilong , Huang Jianping , Shen Yi , Mu Xinru , Zhan Qiwei 
Published: July 2023

Abstract
Seismic anisotropy exists in various types of strata and should be considered in seismic imaging schemes. Seismic imaging algorithms based on isotropic assumption neglect the effects of anisotropy on seismic data, which cause migration artifacts and waveform distortion. To correct the effects of anisotropy on seismic wave propagation, we propose an imaging algorithm that performs least-squares reverse time migration in vertical transversely isotropic acoustic media. We derive the following operators to implement this algorithm, the de-migration operator, its adjoint migration operator, and the corresponding gradient. However, an inaccurate estimated source wavelet will introduce error in the seismic simulation, and thus increase the mismatch between observed and synthetic data for least-squares reverse time migration. In addition, the noises, especially the noises with abnormal amplitudes in the seismic data, damage the inversion convergence and reduce the imaging resolution. To improve the image quality, we propose to use convolved wavefields between observed and synthetic data so that such a mismatch can be independent of the source wavelets. Also, we use the Student’s t-distribution instead of L2 norm in our inversion scheme to better handle the seismic noise. Its implementation only modifies the gradient of the conventional least-square reverse time migration scheme. Our numerical tests show a clear improvement using our proposed imaging algorithm when compared with the conventional isotropic migration scheme for the anisotropic data. Also, the synthetic examples demonstrate the feasibility and effectiveness of our proposed source-independent algorithm using the Student’s t-distribution.
HIVEP3 inhibits fate decision of CD8+ invariant NKT cells after positive selection
Authors: Wu Qielan , Bai Shiyu , Su Miya , Zhang Yuwei , Chen Xuran , Yue Ting , Xu Linfeng , Wang Lu , Xie Di , Li Shuhang , Li Xiang , Fu Sicheng , Wang Lili , Tian Chenxi , Pan Jun , Huang Yuanyuan , Cai Yuting , Wang Yu , Hu Fang , Li Fengyin , Zhang Huimin , Bai Li 
Published: July 2023

Abstract
CD8+ invariant natural killer T (iNKT) cells are functionally different from other iNKT cells and are enriched in human but not in mouse. To date, their developmental pathway and molecular basis for fate decision remain unclear. Here, we report enrichment of CD8+ iNKT cells in neonatal mice due to their more rapid maturation kinetics than CD8− iNKT cells. Along developmental trajectories, CD8+ and CD8− iNKT cells separate at stage 0, following stage 0 double-positive iNKT cells, and differ in HIVEP3 expression. HIVEP3 is lowly expressed in stage 0 CD8+ iNKT cells and negatively controls their development, whereas it is highly expressed in stage 0 CD8− iNKT cells and positively controls their development. Despite no effect on IFN-γ, HIVEP3 inhibits granzyme B but promotes interleukin-4 production in CD8+ iNKT cells. Together, we reveal that, as a negative regulator for CD8+ iNKT fate decision, low expression of HIVEP3 in stage 0 CD8+ iNKT cells favors their development and T helper 1–biased cytokine responses as well as high cytotoxicity.
Neutrophil nucleus: shaping the past and the future
Authors: Salafranca Julia , Ko Jacky Ka , Mukherjee Ananda K , Fritzsche Marco , van Grinsven Erinke , Udalova Irina A 
Published: July 2023

Abstract
Neutrophils are innate immune cells that are key to protecting the host against infection and maintaining body homeostasis. However, if dysregulated, they can contribute to disease, such as in cancer or chronic autoinflammatory disorders. Recent studies have highlighted the heterogeneity in the neutrophil compartment and identified the presence of immature neutrophils and their precursors in these pathologies. Therefore, understanding neutrophil maturity and the mechanisms through which they contribute to disease is critical. Neutrophils were first characterized morphologically by Ehrlich in 1879 using microscopy, and since then, different technologies have been used to assess neutrophil maturity. The advances in the imaging field, including state-of-the-art microscopy and machine learning algorithms for image analysis, reinforce the use of neutrophil nuclear morphology as a fundamental marker of maturity, applicable for objective classification in clinical diagnostics. New emerging approaches, such as the capture of changes in chromatin topology, will provide mechanistic links between the nuclear shape, chromatin organization, and transcriptional regulation during neutrophil maturation.