bluuebunny/crossref_metadata_2025_split huggingface dataset:
The feasibility, facilitators, and barriers in the initial implementation phase of ‘good life with osteoarthritis in Denmark’ (GLA:D®) in Switzerland: a cross-sectional survey
Authors: Hinteregger Anja , Niedermann Karin , Wirz Markus 
Published: September 2023

AbstractBackgroundThe guideline-based, conservative, non-pharmacological management of hip and knee osteoarthritis in clinical practice has been insufficient in Switzerland until now. The implementation of “Good Life with Osteoarthritis in Denmark” (GLA:D®), a programme designed to address this evidence-performance gap, was started in 2019 in Switzerland. This study investigated the acceptance and practicality of the GLA:D® Switzerland programme and identified the facilitators and barriers to its implementation, to support the development of tailored implementation strategies.MethodsThis is a non-experimental observational study. A cross-sectional survey was performed among the physiotherapists (PTs) of the first five GLA:D® Switzerland certification courses, using the Measurement Instrument for Determinants of Innovations (MIDI) to identify the facilitators and barriers. Descriptive statistics were calculated, and qualitative content analysis was used for open-ended questions.ResultsIn the online survey, 86 GLA:D® certified PTs participated (response rate: 61%). The majority of 51 PTs (63.7%) worked in private practices. Of the responding PTs 58 (78.4%) were satisfied with the general concept of the GLA:D® Switzerland programme. Practicality was evaluated positively, particularly the second and third individual session (n = 40 PTs, 83.3%), the 40 m Fast-paced Walk Test (43, 89.6%), the 30 s Chair Stand Test (45, 93.8%), and the exercise programme (40, 83.3%). The marketing (12, 15%), the ‘data entry’ (5, 10.4%), ‘register the patient’ (7, 14.6%), and the digital patient questionnaire (9, 14.2%) were rated less positively. In total, 12 facilitators and 12 barriers were identified. The barriers were mainly related to adopting user, e.g., perceived personal disadvantages. Barriers were also found in the organisational context, e.g., time available. Facilitators were associated with the GLA:D® Switzerland programme itself, e.g., completeness, relevance for patients, and the adopting user, e.g., self-efficacy, and in the organisational context, e.g., material resources and facilities. Topics related to the socio-political context were raised in the answers to the open-ended questions, e.g., general awareness level of the GLA:D® Switzerland programme and patient recruitment.ConclusionThe acceptance, practicality and facilitators identified from the initial implementation are encouraging. However, the identified barriers and activities rated with low practicality require tailored strategies to support a successful implementation of the GLA:D® Switzerland programme.
Type I/type III IFN and related factors regulate JEV infection and BBB endothelial integrity
Authors: Zhang Ya-Ge , Zhang Hong-Xin , Chen Hao-Wei , Lv Penghao , Su Jie , Chen Yan-Ru , Fu Zhen-Fang , Cui Min 
Published: September 2023

Abstract
Background
Japanese encephalitis virus (JEV) remains a predominant cause of Japanese encephalitis (JE) globally. Its infection is usually accompanied by disrupted blood‒brain barrier (BBB) integrity and central nervous system (CNS) inflammation in a poorly understood pathogenesis. Productive JEV infection in brain microvascular endothelial cells (BMECs) is considered the initial event of the virus in penetrating the BBB. Type I/III IFN and related factors have been described as negative regulators in CNS inflammation, whereas their role in JE remains ambiguous.

Methods
RNA-sequencing profiling (RNA-seq), real-time quantitative PCR, enzyme-linked immunosorbent assay, and Western blotting analysis were performed to analyze the gene and protein expression changes between mock- and JEV-infected hBMECs. Bioinformatic tools were used to cluster altered signaling pathway members during JEV infection. The shRNA-mediated immune factor-knockdown hBMECs and the in vitro transwell BBB model were utilized to explore the interrelation between immune factors, as well as between immune factors and BBB endothelial integrity.

Results
RNA-Seq data of JEV-infected hBMECs identified 417, 1256, and 2748 differentially expressed genes (DEGs) at 12, 36, and 72 h post-infection (hpi), respectively. The altered genes clustered into distinct pathways in gene ontology (GO) terms and KEGG pathway enrichment analysis, including host antiviral immune defense and endothelial cell leakage. Further investigation revealed that pattern-recognition receptors (PRRs, including TLR3, RIG-I, and MDA5) sensed JEV and initiated IRF/IFN signaling. IFNs triggered the expression of interferon-induced proteins with tetratricopeptide repeats (IFITs) via the JAK/STAT pathway. Distinct PRRs exert different functions in barrier homeostasis, while treatment with IFN (IFN-β and IFN-λ1) in hBMECs stabilizes the endothelial barrier by alleviating exogenous destruction. Despite the complex interrelationship, IFITs are considered nonessential in the IFN-mediated maintenance of hBMEC barrier integrity.

Conclusions
This research provided the first comprehensive description of the molecular mechanisms of host‒pathogen interplay in hBMECs responding to JEV invasion, in which type I/III IFN and related factors strongly correlated with regulating the hBMEC barrier and restricting JEV infection. This might help with developing an attractive therapeutic strategy in JE.
The barriers, facilitators and association of vaccine certificates on COVID-19 vaccine uptake: a scoping review
Authors: Zhu David T. , Serhan Mohamed , Mithani Salima S. , Smith David , Ang Joyce , Thomas Maya , Wilson Kumanan 
Published: September 2023

Abstract
Background
Globally, COVID-19 vaccines have proven to be instrumental for promoting population health by reducing illness from SARS-CoV-2. Vaccine certificates emerged as a potentially promising solution for encouraging vaccination and facilitating the safe reopening of society, however, they were controversial due to criticisms of infringing upon individual rights. While there is extensive literature describing the ethical, legal, and public health implications of vaccine certificates, there is currently a gap in knowledge about the association of vaccine certificates on vaccine uptake during the COVID-19 pandemic and barriers and facilitators to their use.

Objectives
The objectives of this scoping review are to (i) describe the existing literature on the association of vaccine certificates on the rates of COVID-19 vaccine uptake across several countries and (ii) describe the intrinsic and extrinsic barriers or facilitators that moderate this relationship.

Methods
We conducted a scoping review based on PRISMA Extension for Scoping Reviews (PRSIMA-ScR) guidelines. We searched three bibliographic databases (APA PsychInfo, Embase Classic + Embase, OVID-Medline) and preprint severs during the first week of July 2023. Three reviewers independently screened the studies based on pre-specified eligibility criteria and performed quality assessments of the primary literature and data extraction.

Results
Sixteen studies met the inclusion criteria. 14 or these were surveys and 2 were modelling studies. The majority documented that vaccine certificates were significantly associated with increased rates of COVID-19 vaccine uptake (n = 12), motivated by factors such as travel/employer requirements, influence from the government/peers, and trust in the safety, efficacy, and science behind COVID-19 vaccines. Three studies had non-significant or mixed findings. Only one study found a significant decrease in COVID-19 vaccine uptake, motivated by pervasive distrust in the QR code-based system of digital vaccine certificates in Russia. Quality of survey studies was generally high.

Conclusion
Our findings provide insights into the existing literature on vaccine certificates association with vaccine uptake in several different jurisdictions and barriers and facilitators to their uptake. This information can be used to guide future examinations of the implementation of vaccine certificates and more effective implementations.
The International X-Linked Hypophosphatemia (XLH) Registry: first interim analysis of baseline demographic, genetic and clinical data
Authors: Ariceta Gema , Beck-Nielsen Signe Sparre , Boot Annemieke M. , Brandi Maria Luisa , Briot Karine , de Lucas Collantes Carmen , Emma Francesco , Giannini Sandro , Haffner Dieter , Keen Richard , Levtchenko Elena , Mӓkitie Outi , Mughal M. Zulf , Nilsson Ola , Schnabel Dirk , Tripto-Shkolnik Liana , Liu Jonathan , Williams Angela , Wood Sue , Zillikens M. Carola 
Published: September 2023

Abstract
Background
X-linked hypophosphatemia (XLH) is a rare, hereditary, progressive, renal phosphate-wasting disorder characterized by a pathological increase in FGF23 concentration and activity. Due to its rarity, diagnosis may be delayed, which can adversely affect outcomes. As a chronic disease resulting in progressive accumulation of musculoskeletal manifestations, it is important to understand the natural history of XLH over the patient’s lifetime and the impact of drug treatments and other interventions. This multicentre, international patient registry (International XLH Registry) was established to address the paucity of these data. Here we present the findings of the first interim analysis of the registry.

Results
The International XLH Registry was initiated in August 2017 and includes participants of all ages diagnosed with XLH, regardless of their treatment and management. At the database lock for this first interim analysis (29 March 2021), 579 participants had entered the registry before 30 November 2020 and are included in the analysis (360 children [62.2%], 217 adults [37.5%] and 2 whose ages were not recorded [0.3%]; 64.2% were female). Family history data were available for 319/345 (92.5%) children and 145/187 (77.5%) adults; 62.1% had biological parents affected by XLH. Genetic testing data were available for 341 (94.7%) children and 203 (93.5%) adults; 370/546 (67.8%) had genetic test results; 331/370 (89.5%) had a confirmed PHEX mutation. A notably longer time to diagnosis was observed in adults ≥ 50 years of age (mean [median] duration 9.4 [2.0] years) versus all adults (3.7 [0.1] years) and children (1.0 [0.2] years). Participants presented with normal weight, shorter length or height and elevated body mass index (approximately − 2 and + 2 Z-scores, respectively) versus the general population. Clinical histories were collected for 349 participants (239 children and 110 adults). General data trends for prevalence of bone, dental, renal and joint conditions in all participants were aligned with expectations for a typical population of people with XLH.

Conclusion
The data collected within the International XLH Registry, the largest XLH registry to date, provide substantial information to address the paucity of natural history data, starting with demographic, family history, genetic testing, diagnosis, auxology and baseline data on clinical presentation.
The association between social support provision, psychological capital, subjective well-being and sense of indebtedness among undergraduates with low socioeconomic status
Authors: Xin Zhongyi 
Published: September 2023

Abstract
Background
Social support consists of receipt and provision in the interpersonal exchange process. Many studies have explored and verified the effect of received social support. This study focuses on whether and when social support provision can benefit the providers’ positive psychological capital and subjective well-being.

Methods
A sample of 732 Chinese undergraduates with low socioeconomic status completed questionnaires on social support provision, psychological capital, life satisfaction, positive affect, negative affect, and sense of indebtedness.

Results
The correlation and regression analyses showed that impoverished college students’ social support provision was positively associated with life satisfaction, positive affect, and psychological capital and negatively associated with negative affect. The interaction between the sense of indebtedness and social support provision was negatively associated with life satisfaction, positive affect, and psychological capital, not significantly associated with negative affect.

Conclusion
The results demonstrated that giving social support can be as beneficial as receiving social support, and the sense of indebtedness can limit the benefits. Individuals with a lower sense of indebtedness are more likely to benefit from social support provision. The findings have implications for marginalized groups’ subjective well-being and positive psychological capital and show the necessity of guiding individuals to provide social support while maintaining their autonomy.
Population pharmacokinetic analysis of lopinavir in HIV negative individuals exposed to SARS-CoV-2: a COPEP (COronavirus Post-Exposure Prophylaxis) sub-study
Authors: Thoueille Paul , Delfraysse Margot , Andre Pascal , Buclin Thierry , Decosterd Laurent A. , Fedeli Chiara , Ustero Pilar , Calmy Alexandra , Guidi Monia ,   the Swiss HIV Cohort Study
Published: September 2023

Abstract
Background
Lopinavir/ritonavir (LPV/r) is a drug traditionally used for the treatment of HIV that has been repurposed as a potential post-exposure prophylaxis agent against COVID-19 in the COronavirus Post-Exposure Prophylaxis (COPEP) study. The present analysis aims to evaluate LPV levels in individuals exposed to SARS-CoV-2 versus people living with HIV (PLWH) by developing a population pharmacokinetic (popPK) model, while characterizing external and patient-related factors that might affect LPV exposure along with dose–response association.

Methods
We built a popPK model on 105 LPV concentrations measured in 105 HIV-negative COPEP individuals exposed to SARS-CoV-2, complemented with 170 LPV concentrations from 119 PLWH followed in our routine therapeutic drug-monitoring programme. Published LPV popPK models developed in PLWH and in COVID-19 patients were retrieved and validated in our study population by mean prediction error (MPE) and root mean square error (RMSE). The association between LPV model-predicted residual concentrations (Cmin) and the appearance of the COVID-19 infection in the COPEP participants was investigated.

Results
A one-compartment model with linear absorption and elimination best described LPV concentrations in both our analysis and in the majority of the identified studies. Globally, similar PK parameters were found in all PK models, and provided close MPEs (from -19.4% to 8.0%, with a RMSE of 3.4% to 49.5%). No statistically significant association between Cmin and the occurrence of a COVID-19 infection could be detected.

Conclusion
Our analysis indicated that LPV circulating concentrations were similar between COPEP participants and PLWH, and that published popPK models described our data in a comparable way.
In the Name of Sovereignty
Authors: Fung Cherise 
Published: September 2023

AbstractIn a post-9/11 world, the figure of the female suicide bomber has emerged as a contentious figure in global discourse. Through the character of Saraswathi, Nayomi Munaweera’s novel Island of a Thousand Mirrors (2012) foregrounds how the construction of this subaltern figure hinges on her susceptibility to rape. This relationship between rape and suicide bombing is deployed differently by the counterterrorist institutions that target her and the ethnonationalist movements that recruit her to make her speak as both victim and agent while silencing her. This article thus argues that we need to move away from the framework of victimhood and agency, which assumes subjectivity without accounting for how the body of the female subaltern is excluded from inhabiting subjecthood as a construct of bounded national sovereignty. Using Jasbir Puar’s theory of queer assemblage, the author explains how Saraswathi’s suicide bomber in ITM is constructed as a figure of antinormative subjectivity through a discourse of U.S. exceptionalism in opposition to a normative U.S. national identity and sovereignty. The author builds on Puar’s insights, which draw on affect theory, to rethink Saraswathi’s violent protest as a moment that destabilizes these normative identities and their related social scripts. The author further posits alternative visions of antinormative subjectivity in the novel that allow for Saraswathi’s survival after her rape.
“We Are Orlando”
Authors: Torres Julie 
Published: September 2023

AbstractThe 2016 shooting at Pulse Nightclub in Orlando, Florida, was mourned as an unspeakable act of violence against the lesbian, gay, bisexual, transgender, and queer (LGBTQ+) community. But what was perhaps less audible was the fact that Latinxs, particularly Puerto Ricans, who represent more than one million of the state’s population, were disproportionally affected. In the wake of the tragedy, a group of Puerto Rican women came together to demand translation and mental health services for survivors and their families. This article details their public refusals to be silenced from the public imaginary of mourning and loss. It also considers how the multiple subject positions of Puerto Ricans shape belonging both locally and across transnational borders. In doing so, the author makes the case for an intersectional analysis of mass violence, mourning, and resistance, in order to generate inclusive spaces and a more just vision for the future.
(Mis)Translations of the Critiques of Anti-Muslim Racism and the Repercussions for Transnational Feminist Solidarities
Authors: Korkman Zeynep K. 
Published: September 2023

AbstractAs critiques of anti-Muslim racism travel transnationally, they get translated in relation to complex histories of imperialism, colonialism, postcolonialism, and nationalism. These (mis)translations produce unexpected uses and abuses of anti-Muslim racism as an academic and political concept, with significant consequences for transnational feminist solidarity. This article explores, as a case in point, the emergence of a “Black Turk” identity in millennial Turkey where pious Muslim identity, once marginalized under a secularist state, has reasserted itself by deploying an analogy of Black to pious Muslim. Obscuring the nuances of local power relations, the pious Muslim/secular fault line was oversimplified and mistranslated into the resonant American idiom of the Black/white binary. This analogy and the progressive critiques of anti-Black and especially anti-Muslim racisms were then instrumentalized by an increasingly authoritarian and gender-conservative Islamist Turkish government to legitimize its repressive agendas, even succeeding to garner unexpected sympathy from some feminist politicians and academics in the United States. Naive confidence that such dichotomous racial/religious categories and familiar political vocabularies can guide feminist analyses and politics risks employing a seemingly transnationalist and anti-imperialist but in truth U.S.-centric understanding of non-U.S. struggles for social justice and thwarting potential transnational feminist solidarities.
Investigation of hepatitis B virus mutations associated with immune escape and drug resistance in human immunodeficiency virus-infected patients
Authors: Modise Lorato , Sithebe Nomathamsanqa , Mufhandu Hazel 
Published: September 2023

Background: HBV/HIV co-infection impact on high HBV replication, progression to liver cancer and high mortality. Co-infection may lead to cross-resistance of HBV and HIV drugs due to immune therapy pressure or hepatotoxicity. These challenges necessitate continuous monitoring of HBV variants to aid better diagnosis and treatment strategies. We conducted this study to characterise HBV among HIV infected individuals. Methods: Serum was screened for HBsAg using ELISA, followed by DNA extraction, PCR amplification, Sanger sequencing and phylogenetic analysis. Results: Of the 50 samples in this study 100% (N=50/50) were HBsAg positive; 78% (N=41/50) HBV/HIV co-infection and 92% (N=38/41) of the amplicons were successfully sequenced. Samples nucleotide sequences were identified as genotype A. Mutations prevalence in the HBsAg region was 47% (N=18/38); including mutations associated with diagnostic failure (K122R and T143S) and 7 vaccines escape mutations (P127T, G145R, S207N, Y200T, E164D, Y206H and L209V). Mutations showed resistance to lamivudine 71% (n=5/7), telbivudine 57% (n=4/7), 14% (n=1/7) for entecavir and 43% (n=3/7) for adefovir. Mutations causing resistance to lamivudine and telbivudine were M204V, L180M, V163I, and S202K; with S202K also causing resistance to entecavir and adefovir resistance mutation were I253Y, I223V and M250I. Multiple drug resistance mutations within a single sample contained L180M, M204V, S202K and M250I mutations. There was no statistical significance between the RT mutations associated with drug resistance at P>0.005. The correlation test exhibited a weak statistical association between SHB and RT mutations (0.877**). Conclusions: This study shows the predominance of HBV genotype A in HIV-infected patients. We discovered HBV mutations linked to immune evasion and drug resistance. Although there is no statistical significance amongst the mutations associated with drug resistance and vaccine escape. These mutations could have clinical implications that could have therapeutic repercussions by influencing the correct clinical diagnosis and treatment in HBV/ HIV co-infected individuals.
An Exact Method for a First-Mile Ridesharing Problem
Authors: Wang Sihan , Baldacci Roberto , Yu Yang , Zhang Yu , Tang Jiafu , Luo Xinggang , Sun Wei 
Published: September 2023

Motivated by the worldwide development of shared mobility, we investigate a vehicle routing problem with time windows and deadlines called the first-mile ridesharing problem (FMRSP). The FMRSP involves routing a fleet of vehicles, each servicing customers within specific time windows. The FMRSP generalizes the well-known vehicle routing problem with time windows (VRPTW), additionally imposing that each vehicle route arrives at the destination before the earliest deadline associated with the set of customers served by the route. The FMRSP is also related to the VRPTW and release dates, where in addition to time window constraints, a release date is associated with each customer defining the earliest time that the order is available to leave the depot for delivery. For the FMRSP, we present an exact method based on a branch-price-and-cut (BPC) algorithm combining state-of-the-art techniques and an innovative pricing algorithm. The pricing algorithm is based on a bidirectional bucket graph-based labeling algorithm, in which the backward extension of a label is computed in a constant time. Effective dominance rules used to speed up the computation are also described. Extensive computational studies demonstrate that our proposed BPC algorithm can solve optimality-modified Solomon benchmark instances involving up to 100 customers and real-world instances involving up to 290 customers. Funding: This research was supported by the National Natural Science Foundation of China [Grants 71831003, 72171043, 71831006, and 71901180]. Supplemental Material: The online appendix is available at https://doi.org/10.1287/trsc.2022.0139 .