bluuebunny/crossref_metadata_2025_split huggingface dataset:
Leveraging Big Data Analytics for Intelligent Transportation Systems: Optimize the Internet of Vehicles Data Structure and Modeling
Authors: Gebremeskel Gebeyehu Belay 
Published: January 2023

Abstract
An intelligent transportation system is an efficient and modern digital approach to dealing with massive data, which is pertinent for a future smart city. It is the inherent challenge of data processing in classic vehicular systems. Therefore, I proposed Big Data Analytics (BDA) to optimize the location and safety-based data analytics and performance measures for complete and informative learning processes in various circumstances. The data preprocessing and feature extraction process includes vehicle mobility, multi-source data acquisition, distributed computation, and multi-path data communication in an analytical model to enhance performance and safety. The proposed approach is capable and scalable to manage large-scale sensor data in various contexts. The findings revealed the possible trajectory gained from the online transaction and information flow on digital and safe ITS applications. The experiment showed that leveraging big data technology enhances safe and optimal vehicular system applications. It provides access to shared resources through connected devices and reduces costs using the response time and data structuring to the system stability and to accommodate future modifications in sensor technology.
From marginal zone lymphoma to aggressive diffuse large B-cell lymphoma: a whole-exome and clinicopathological characteristics analysis of transformed lymphoma
Authors: Zhao Xia , Bian Haiyan , Hao Fengyun , Shao Shihong , Wu Chuanhong , Zhang Qian , Zhao Xiangzhong , Wu Mingxuan , Li Zhiqiang , Gao Chengwen 
Published: January 2023

Abstract
Background
Transformed lymphoma occurs when indolent lymphoma transforms into more aggressive lymphoma usually associated with poor prognosis.
Methods
In this study, we analyzed the immunophenotypes, prognostic factors, and outcomes of 35 patients with transformed lymphoma from among 306 marginal zone lymphoma (MZL), 544 follicular lymphoma (FL), and 871 chronic lymphocytic leukaemia/small lymphocytic lymphoma (CLL/SLL) cases. In addition, we performed whole-exome sequencing study of 7 transformed MZL (tMZL) cases.
Results
Our results demonstrate that the median time from indolent lymphoma diagnosis to transformed DLBCL was 35 months (range, 14–53 months). The 5-year overall survival (OS) and progression-free survival (PFS) rates after histological transformation (HT) were 50% and 26%, respectively. Kaplan-Meier survival analysis revealed that asynchronous HT and transformed CLL/SLL (tCLL/SLL) were significant adverse prognostic factors for OS after DLBCL HT. Our study found that TNFAIP3 was the most frequently mutated gene in tMZL samples. We identified mutations involvement in chromatin remodeling (CREBBP and EP300) and regulators of NF-κB signaling(TNFAIP3, BCL10, MYD88, CD79B, and CARD11) were affected in tMZL.
Conclusion
Whole-exome sequencing and copy-number analysis revealed that tMZL derives from the divergent evolution of an ancestral common progenitor clone (CPC). Collectively, this study provides clinicopathological characteristics of three common types of transformed lymphomas and the genetic profile of tMZL with diagnostic and therapeutic implications.
Relevance of circulating Semaphorin 4A for rheumatoid arthritis progression and response to treatment
Authors: Avouac Jérôme , Vandebeuque Eloïse , Combier Alice , Poiroux Lucile , Barnetche Thomas , Truchetet Marie-Elise , Richez Christophe , Allanore Yannick , Steelandt Alexia 
Published: January 2023

Abstract
The lack of validated tools to predict rheumatoid arthritis (RA) disease course warrants the development of new reliable biomarkers. Our aim was to evaluate the merit of circulating SEMA4A for the prediction of outcomes in patients with RA. In a first cohort of 101 consecutive RA patients followed up for 41±15 months, increased baseline SEMA4A levels were identified as an independent predictor of disease progression (hazard ratio, HR: 2.71, 95%CI 1.14–6.43), defined by the occurrence of patient-reported flares and initiation or change of targeted therapy. The highest predictive value of disease progression was obtained with the combination of increased circulating SEMA4A and/or Disease Activity Score (DAS) 28-CRP > 3.2 and/or synovial hyperemia on doppler ultrasound (HR: 10.42, 95%CI 1.41–76.94). In a second independent cohort of 40 consecutive RA patients who initiated new therapy because of insufficient disease control, baseline SEMA4A levels were significantly higher in patients who further experienced none or moderate response, and SEMA4A concentrations were markedly decreased in the group of patients with good clinical response as compared to non-responders. Circulating SEMA4A appears as an appealing biomarker in RA with ability to predict disease progression, and with association with response to therapy.
Deformation Error Compensation in 5-Axis Milling Operations of Turbine Blades
Authors: Soori Mohsen 
Published: January 2023

Abstract
The precision and performance of machined flexible parts are under influence of deformation errors during end milling operations. Thus, prediction and compensation of deformation errors during milling operations of flexible parts can provide a key tool in accuracy enhancement of part production. In this study, an improved virtual machining system is proposed in order to assess and compensate deformation errors caused by cutting temperature and forces in 5-axis milling operations of flexible parts. The improved Johnson–Cook model is utilized to investigate the cumulative impact of strain rate and deformation temperatures on flow stress during milling operations of turbine blade. To estimate deformation errors caused by cutting forces and temperature on the workpiece and cutting tool, the finite element analysis is then applied. As a result, volumetric vectors of deformation error at each cutting location along the machining pathways are then generated in order to be compensated within new compensated machining tool paths. Thus, the deformation error created by cutting forces and temperature on the workpiece and cutting tool are compensated in order to enhance accuracy during 5-axis milling operation of flexible turbine blades. Experiments are carried out using a 5-axis CNC machine tool and errors are quantified using a CMM to verify the developed strategy in the study. As a consequence, precision of machining operations on flexible turbine blades can be enhanced by employing the developed virtual machining system in the study.
Co-infection of Microsporidia with Mycobacterium tuberculosis in pulmonary patients
Authors: Liu Lirong , Ni Lan , Mo Biying , Yue Jun , Cheng Zhenshun , Chen Jie , Bao Jialing , Zhou Zeyang 
Published: January 2023

Abstract
[Background] Co-infection of multiple pathogens into one host is a great threat to public health, for it exacerbates symptoms and leads to worse outcomes compared to single pathogen infection. Both Mycobacterium tuberculosis (Mtb) and microsporidia are wide spread pathogens world-widely. However, the co-infection of Mycobacterium tuberculosis with microsporidia has long been underestimated.
[Methods] Current study recruited Mtb-positive pulmonary patients and Mtb-negative patients yet immune-suppressed due to various causes. Stool samples were collected from these two groups of individuals and the total DNAs were isolated. Quantitative PCR (qPCR) assay was used to detect the presence of microsporidia in these samples.
[Results] The results showed that infection rates of microsporidia are 39.6% (23/58) in Mtb-positive group and 50% (4/8) in Mtb-negative yet immune-suppressed group. Sequencing of the positive further revealed that the infected microsporidia species include all four common human-infecting microsporidia which are Enterocytozoon bieneusi, Encephalitozoon intestinalis, Encephalitozoon cuniculi and Encephalitozoon hellem.
[Conclusion] Our report is the first to investigate and compare the influences of Mtb-infection and host immune state in microsporidia infection. Our findings demonstrated that microsporidia have high co-infection incidence with Mtb, and the host immune state has profound influence on infection of microsporidia.
[Trial Registration] N/A.
Progression to Myocardial Infarction Short-Term Death Based on Interval Sequential Pattern Mining
Authors: Wu Yang-Sheng , Taniar David , Adhinugraha Kiki , Wang Chao-Hung , Pai Tun-Wen 
Published: January 2023

Abstract
Background
Cardiovascular disease (CVD) is the leading cause of death globally, contributing to 32% of all global deaths. Moreover, myocardial infarction (MI) causes 11.9% of deaths among CVD patients. According to our Taiwan health insurance database analysis, the hazard rate reaches a peak in the initial year after diagnosis, drops to a relatively low value, and maintains stability for the following years. Therefore, identifying suspicious comorbidities before the diagnosis that may lead MI patients to short-term death is paramount.
Methods
Interval sequential pattern mining was applied with odds ratio to the hospitalization records from the Taiwan health insurance research database to evaluate the disease progression and identify potential subjects at the earliest stage possible.
Results
Our analysis resulted in five disease pathways, including “diabetes mellitus,” “other disorders of the urethra and urinary tract,” “essential hypertension,” “hypertensive heart disease,” and “other forms of chronic ischemic heart disease” that led to short-term death after MI diagnosis, and these pathways covered half of the cohort.
Conclusion
We explored the possibility of establishing trajectory patterns to identify the high-risk population of early mortality after MI.
Effect of low-magnitude, variable-frequency vibration therapy on pain threshold levels and mobility in adults with moderate knee osteoarthritis - randomized controlled trial
Authors: Pasterczyk-Szczurek Alicja , Golec Joanna , Golec Edward 
Published: January 2023

Abstract
Background: Osteoarthritis (OA) is one of the most commonly recorded diseases in clinical practice. Vibration therapy has been suggested for the treatment of knee OA. The purpose of the study was to determine the impact of vibrations of variable frequency and low amplitude on pain perception and mobility in patients suffering from knee OA.
Methods: 32 participants were allocated into two groups – Group 1 (oscillatory cycloidal vibrotherapy-OCV) and Group 2 - control (sham therapy). The participants were diagnosed with moderate degenerative changes in the knee (grade II based on the Kellgren-Lawrence (KL) Grading Scale). Subjects received 15 sessions of vibration therapy and sham therapy respectively. Pain, range of motion, and functional disability were assessed through Visual Analog Scale (VAS), Laitinen questionnaire, goniometer (ROM – range of motion), timed up and go test (TUG) and Knee Injury and Osteoarthritis Outcome Score (KOOS). Measurements were taken at baseline, after the last session and four weeks after the last session (follow up). T-test and U-Mann Whitney test compare baseline characteristics. The Wilcoxon and ANOVA tests compared mean VAS, Laitinen, ROM, TUG and KOOS. The significant P-value was less than 0.05.
Results: After 3 weeks (15 sessions) of vibration therapy, reduced the sensation of pain and improved mobility was recorded. There was a more significant improvement in the vibration therapy group than the control group in pain alleviation on VAS scale (p <0.001), on Laitinen scale (p <0.001), knee ROMs flexions (p <0.001) and TUG (p <0.001) at the last session. KOOS score with pain indicator, symptoms, activities of daily living, function in sport and recreation and knee related quality of life improved more in the vibration therapy group than the control group. Effects maintained up to 4 weeks in vibration group. No adverse events were reported.
Conclusions: Our data demonstrated that the use of vibrations of variable frequency and low amplitude in patients with the knee OA is a safe and effective therapy. It is recommended to increase the number of treatments performed, primarily in patients with degeneration II° according to the KL classification.
Trial registration: Prospectively registered on ANZCTR (ACTRN12619000832178). Registered on 11 June 2019. https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?ACTRN=12619000832178
The translatome of Glioblastoma multiforme
Authors: Cornelissen F. M.G. , He A. , Haas R. R. , Houweling M. , Noske D. , Vandertop W. P. , Piersma S. R. , Jiménez CR. , Murre C. , Westerman BA. 
Published: January 2023

Abstract
Glioblastoma Multiforme (GBM) is the most common and aggressive brain tumor, containing intrinsic resistance to current therapies leading to poor clinical outcomes. Therefore, understanding the underlying mechanisms of GBM is an urgent medical need. Although radiotherapy contributes significantly to patient survival, GBMs recur typically within the initial radiation target volume, suggesting remaining GBM cells are highly radioresistant. Deregulation of the protein translation mechanism has been shown to contribute to cancer progression by driving translational control of specific mRNA transcripts involved in cancer cell regulation. To identify new potential therapeutic targets for the treatment of GBM we pioneered ribosome profiling of glioblastoma sphere cultures (GSCs) under normal and radiotherapeutic conditions. We found that the global translation of genes matched and overlapped with previously published GBM subtypes, based on the transcriptional level. In addition, we revealed a broad spectrum of open reading frame types in both coding and non-coding regions, including a set of lncRNAs and pseudogenes undergoing active translation. In addition, we identified new mRNA transcripts being translated. Finally, we show that translation of histones is inhibited while splicing factors are more intensively translated after irradiation of GSCs. Together, our unprecedented GBM riboprofiling provides new insights in real time protein synthesis in GBM under normal and radiotherapeutic conditions which forms a resource for future research and provides potential new targets for therapy. Teaser We show a pioneering riboprofiling effort of glioblastoma (GBM), which provides new insights in real-time protein synthesis under normal and radiotherapeutic conditions. We found that the global translation of genes matched and overlapped with previously published GBM subtypes, as based on the transcriptional level. In addition, we revealed a broad spectrum of open reading frame types in both coding and non-coding regions, including a set of lncRNAs and pseudogenes undergoing active translation. In addition, we identified new mRNA transcripts being translated. Finally, we show that translation of histones is inhibited while splicing factors are more intensively translated after irradiation of GSCs. Our data form a resource for future research and provides potential new targets for therapy.
Completion of Four or More ANC Visits Among Women of Reproductive Age in a Rural District in Uganda: A Quantitative Study on the Role of Service-Level Factors
Authors: Muhirwe Lorna Barungi , Aagard Magdeline 
Published: January 2023

Abstract

Uganda is one of 24 countries in the world where 70% of global maternal deaths occur. Evidence indicates that antenatal care (ANC) has both indirect and direct effects on maternal and perinatal morbidity and mortality reduction. In Uganda, the ANC attendance rate stands at 97.3% for one visit, but 59.9% for four or more visits. The aim of this quantitative study was to assess service- level factors affecting completion of ANC attendance defined by completion of four or more visits among women of reproductive age in a rural district in Uganda to contribute to design of patient-centered ANC services. Facility assessment scores on the service-level factors of interest for health facilities were obtained using a service level index tool. The relationship between the ANC completion rates of clients sampled from records at the health facilities and facility scores on service-level factors of interest were analyzed. Regression was conducted to determine the predictive relationship between ANC service availability, ANC service content, and ANC service organization, and completion of ANC attendance. The model was statistically significant, χ2 (6) = 26.118, p ˂ 0.05, and accounted for approximately 17.3% of the variance of ANC attendance completion (R2 = .173). Completion of ANC attendance was primarily predicted by better timing of provision of ANC services, and to a lesser extent by higher levels of availability of medicines and medical supplies. This study demonstrated that service-level factors have a predictive value for completion of ANC attendance. The findings can be used to improve availability, content, and organization of ANC services with the aim of enhancing positive experiences for clients and motivating them to complete the recommended number of ANC visits.
L’évolution clinique des patients atteints de hernie idiopathique de la moelle épinière: une série de cas.
Authors: Paquet Jérôme , Flageol Stéphanie , Cottin Sylvine Carrondo , Turmel André , Côté Isabelle 
Published: January 2023

Abstract

Study Design
This study is a case series of 48 patients.
Objectives
This study’s primary objective was to provide a clinical description of a group of individuals with a working diagnosis of idiopathic spinal cord herniation (ISCH). The secondary objectives were to appreciate the natural history of these patients and describe their clinical evolution with conservative or surgical management.
Setting
The study was carried out at l’Hôpital de l’Enfant-Jésus, CHU de Québec (Québec, Canada), a tertiary care university hospital.
Methods
This case series study is based on routinely collected data. Forty-eight (48) cases were identified as having an ISCH on MR imaging, between 2009 and 2019. Their medical files have been searched retrospectively. Patient characteristics were described according to their asymptomatic or symptomatic status.
Results
The mean age of patients at the time of diagnosis was 52.5 years. Most of the patients identified were asymptomatic (69%) and followed clinically. The main neurologic presentation for the symptomatic group was Brown-Séquard-like syndrome. 20% of the symptomatic patients were rapidly treated surgically after consultation with the neurosurgeon. The mean follow-up duration was 56 months for asymptomatic patients and 51 months for symptomatic patients. Most of our patients (41 out of 45) were considered stable or unchanged at follow-up. There was no neurological progression in all asymptomatic patients.
Conclusions
Our study shows that ISCH and its variants are not always symptomatic and may be a fortuitous finding. As the natural history may be non-progressive, it is probably appropriate to treat some cases expectantly.
Fuzzy real weak inner product: A new approach
Authors: BYUN TAECHANG , Lee Ji Eun , Yoon Jin Hee 
Published: January 2023

Abstract
There are various kinds of fuzzy inner products.
It was shown \cite{BLLY} that a fuzzy inner product on a vector space, producing a fuzzy real number as its value, is merely the embedding of a real valued inner product into the fuzzy number systems over the set of tuples consisting of elements in the space because of its linear property.
Thus the linear property is needed to be weakened. In this paper, a new concept, called a \emph{fuzzy real weak inner product} on a vector space, is introduced and some nontrivial examples are given.
Then, a fuzzy real weak inner product in a suitable condition is deeply studied, which may be either almost positive-definite or positive-definite. Furthermore, it satisfies both Cauchy inequality and Parallelogram law even though it is not linear. And some properties of a general type of a fuzzy real weak inner product, especially the approximation related to the Parallelogram law, are investigated in analytic viewpoint.
Older age, internal carotid artery stenosis, and female sex as factors correlated with twisted carotid bifurcation based on 457 angiographic studies and a literature review
Authors: Tokugawa Joji , Kudo Kentaro , Mitsuhashi Takumi , Mitsuhashi Takashi , Hishii Makoto 
Published: January 2023

Abstract
Twisted carotid bifurcation (TCB) is a well-known anatomical variation of the carotid bifurcation in patients undergoing carotid endarterectomy. However, few investigations of TCB have focused on patients without internal carotid artery (ICA) stenosis. This study was performed to analyze the characteristics of TCB in patients with ICA stenosis and other diverse pathologies. All conventional cerebral angiographies performed in our institute for any reason from January 2012 to December 2018 were reviewed. The patients were divided into two groups, the TCB group and the anatomically normal non-TCB group, and the basic characteristics of the groups were analyzed. Both sides of the carotid bifurcation were clearly visualized in 457 patients. TCB was found in 89 of 457 patients (19.5%); among these 89 patients, 74 (83.1%) had TCB only on the right side, 8 (9.0%) only on the left side, and 7 (7.9%) bilaterally. TCB was found more frequently on the right than left [81 (17.7%) and 15 (3.3%), respectively, on each of the 457 sides (p < 0.0001)]. TCB was significantly more frequent in older patients (p = 0.02), female patients (p < 0.001), and patients with ICA stenosis or occlusion at the bifurcation (p = 0.005). The prevalence of TCB was 19.5%, and 84.4% of cases were on the right side in patients with diverse pathologies. In conclusion, older patients, female patients, and patients with ICA stenosis or occlusion are more prone to have TCB.