bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inhibition of p62-Keap1-Nrf2 Pathway Activation by Realgar Promotes
the Inhibition of Esophageal Cancer Cell Proliferation, Migration, and
Ferroptosis
Authors: Zhang Xiaolan , Yang Ruyi , Wang Hongbin , Cao Changxia , Zhao Wenling , Duan Lingyan , Chen Fazhang 
Published: December 2022

Background:
Realgar, a Chinese herbal decoction, has been used to treat various types of
tumors with positive outcomes; however, there is a lack of convincing evidence on its use for the treatment
of esophageal cancer (EC). In this study, the role of the p62-Kelch-like ECH-associated protein 1
(Keap1)-nuclear factor erythroid 2-related factor 2 (Nrf2) pathway in the regulation of EC cell proliferation,
migration, and ferroptosis in response to realgar was assessed.

Methods:
Different concentrations of realgar (0, 10, 20, 40, 60, 80, and 100 μmol/L) were applied to the
EC cell lines Eca109 and KYSE150. The inhibition rate and half-inhibitory concentration (IC50) were
determined using the Cell Counting Kit-8 (CCK-8) method. Subsequently, the cells were treated with
realgar (1/2IC50, IC50, 2IC50). Cell migration was measured using the scratch assay, and cell invasion
was measured using the transwell assay. The mRNA expression of p62, Keap1, and Nrf2 was measured
by quantitative real-time polymerase chain reaction (qRT-PCR), and the protein expression of p62,
Keap1, Nrf2, matrix metalloproteinase (MMP)-2, MMP-9, E-cadherin, Slug, N-cadherin, and vimentin
was measured by Western blot. The control, 2IC50, shRNA-NC, shRNA-p62, 2IC50 + shRNA-NC, 2IC50
+ shRNA-p62, shRNA-Keap1, 2IC50 + shRNA-Keap1, and 2IC50 + shRNA-p62 + shRNA-Keap1 groups
were defined. The CCK-8 method was used to measure the cell inhibition rate, and the clone formation
assay was used to measure the clone formation ability. Moreover, the scratch assay was used to detect
the cell migration ability, and the transwell assay was used to detect the cell invasion ability. Transmission
electron microscopy was used to observe the mitochondrial morphology, Prussian blue staining was
used to observe the intracellular iron particle distribution, and flow cytometry was used to detect changes
in intracellular reactive oxygen species. In addition, qRT-PCR was performed to detect p62, Keap1,
Nrf2, and glutathione peroxidase 4 (GPX4) mRNA expression, and Western blot was performed to detect
p62, Keap1, Nrf2, E-cadherin, Slug, N-cadherin, and GPX4 protein expression.

Results:
Realgar inhibited Eca109 and KYSE150 cell proliferation in a time- and concentrationdependent
manner. It also significantly inhibited the migration and invasion of Eca109 and KYSE150
cells and affected the mRNA and protein expression of p62, Keap1, and Nrf2. In response to realgar,
low p62 expression inhibited the proliferation, migration, and invasion of Eca109 and KYSE150 cells,
as well as ferroptosis induction.

Conclusion:
The findings demonstrate that inhibiting the p62-Keap1-Nrf2 signaling pathway promotes
the inhibitory effects of realgar on EC cells.
Survival and Analysis of Predictors of Mortality in Patients Undergoing Hemodialysis in a Rural Hospital in Puducherry, India: A Retrospective Cohort Study
Authors: Ravi Kumar P. , Vinayagmoorthy V. , Dongre Amol , Deshmukh Pradeep 
Published: December 2022

Background:
Despite the advent of dialysis technology, the survival of patients on hemodialysis (HD) is not encouraging. There is little information available regarding the prognostic factors of HD, its population characteristics, or outcomes in India.

Objectives:
We attempted to describe the profile of patients on HD, estimate the mean days of their survival and to determine the various factors associated with their survival.

Materials and Methods:
It was a retrospective cohort study conducted on patients who were on maintenance HD, registered during the five-year period between 1st January 2014 and 31st December 2018 in a tertiary care teaching hospital in Rural Puducherry, South India. Demographic, hematological, biochemical, electrocardiographic, echocardiographic parameters and death during follow-up were extracted from the dialysis database after de-identification. The survival rate was calculated using Kaplan- Meir Curves and Cox Regression analysis was done to estimate the adjusted hazard ratio.

Results:
The median survival of the 229 eligible patients on HD was 819 days. Cardiac pathology accounted for 25.7% of those deaths and 33.9% was sudden death. Adjusted Cox proportional model showed the presence of Left Ventricular Hypertrophy (LVH) (HR: 78.1), increase in phosphorus (HR: 1.26), decrease in haemoglobin (HR: 0.78), and decrease in serum albumin (HR: 0.52) were significant bad prognostic factors.

Conclusion:
Screening for LVH, anemia, hypoaluminemia and hyperphosphatemia amongst HD patients and managing them to prevent these bad prognostic factors has the potential to improve their survival.
Study on Microwave-assisted Reduction of Pyrolusite
Authors: Liu Dongjie , Du Jinjia , Dai Qingqing , Zhou Junwen 
Published: December 2022

Abstract:
Manganese is a vital metal resource, and increased consumption of manganese is leading
to the shortage of high-grade manganese ore resources. However, a large number of low-grade
manganese ore resources ((Mn<30%) accounts for about 60% of the total manganese resources)
have not been effectively utilized because of the lack of efficient industrial utilization methods.
Researching new technologies for reducing low-grade pyrolusite is an urgent problem to be solved.
Microwave is an effective and environmentally friendly heat source widely used in mining, metallurgy,
and chemistry. Different substances have different dielectric constants. The difference in
dielectric constant affects the absorption rate of substances, resulting in different heating rates for
different substances when heated by microwaves. Microwave is widely used in the metal smelting
process because of its unique heating method. So far, few works have been done to verify that
microwave heating can effectively promote the reduction of pyrolusite. This article summarizes
some current methods of reducing low-grade pyrolusite and compares them with the method of
reducing pyrolusite by microwave heating. In addition, this article introduces the principle of microwave-
enhanced reduction of pyrolusite and discusses the opportunities and challenges faced by
microwave heating technology in its subsequent development. The aim is to analyze and study the
promoting effect of microwave heating technology on the reduction of pyrolusite, further improve
the utilization of low-grade pyrolusite, and provide new methods and approaches for the comprehensive
utilization of mineral resources and provide assistance in industrial production.
Statistical Optimization of Carbon Dioxide Capture Performance
by Tri-Solvent System of MEA-DEA-PZ from the Stored Gas
Reservoir
Authors: Sood Akash , Thakur Avinash , Ahuja Sandeep Mohan 
Published: December 2022

Aims/Objective:
The current study evaluates the effectiveness of a blended
tri-solvent system composed of monoethanolamine (MEA), diethanolamine (DEA), and
piperazine (PZ) for removing the carbon dioxide (CO2) from the stored gas reservoir.
The developed system is intended to be both environmentally benign and productive.

Methods:
The CO2 absorption was carried out for the total solvent (5, 10, and 15%
v/v), during the course of three temperature ranges (20, 25, and 30°C) while maintaining
the reservoir pressure of 1.5, 2, and 2.5 bar. The fraction of DEA: MEA has been
restricted to 0.2, 0.5, and 0.8, with simultaneous loading of anhydrous PZ ranging
from 0 to 2 gm. and agitation speed for step intervals of 300, 600, and 900 rpm. For
the purpose of investigating the synergetic effects of the process parameters on the
rapid absorption of CO2 (ξ) and the initial CO2 absorption rate (ε0), Box-Behnken
Design (BBD) of response surface methodology (RSM) has been exploited. The design
of experiments (DoE) assisted artificial neural network (ANN) and metaheuristic
approach of hybridising ANN-whale optimization algorithm (WOA) was also developed
and utilised to train and test the developed model. Three optimization models based on
RSM, DoE-WOA and ANN-WOA were compared. Under the optimized operating conditions
pertaining to DoE, DoE-WOA and DoE-ANN-WOA, (ε0 = 3.340, 3.460 3.513
gm./min-250 mL) and (ξ = 17.114, 18.069, 18.145 gm./250 mL) were obtained.

Results:
The hybridised DoE-ANN-WOA shows promising results in correlation with
the experimental outcomes having error % for ε0 & ξ of 0.790 & 1.31.

Conclusion:
The DoE-ANN-WOA tends to be selected to predict the optimal absorption
conditions as compared to other optimization techniques used in current article.
Studi Erosi Dan Sedimentasi Tambang Batubara Pada Pit Pinang South Pt. Kaltim Prima Coal Menggunakan Geographic Information System (ArcGIS)
Authors: Muhtasar Iqbal Maulana , Sholichin Moh. , Asmaranto Runi 
Published: December 2022

Penambangan batubara oleh PT.Kaltim Prima Coal (KPC)Â merupakan penambangan terbuka, sehingga dapat menimbulkan hilangnya bentuk permukaan bumi, meninggalkan lubang-lubang besar di permukaan bumi, erosi, sedimentasi, maupun penurunan produktivitas tanah. Oleh karena itu diperlukan reklamasi dan rehabilitasi lahan bekas tambang. Dalam proses reklamasi pasca tambang dibutuhkan spesifikasi khusus agar hasil dari reklamasi sesuai dengan yang diharapkan. Faktor-faktor erosi yang memenuhi persamaan USLE dapat diolah dengan mudah menggunakan bantuan Sistem Informasi Geografis. Dari hasil perhitungan pada Pit Pinang South PT.KPC, didapatkan laju erosi 32,62 (ton/ha/tahun), daerah yang mengalami erosi sangat ringan seluas 27,26 ha (35,12%), erosi ringan seluas 27,89 ha (35,94%), erosi sedang seluas 20,60 ha (26,54%), erosi berat seluas 1,62 ha (2,08%), dan erosi sangat berat seluas 0,21 ha (0,27%). Berdasarkan perhitungan SDR, didapatkan hasil sebesar 1440,8 ton/tahun, sedangkan perkiraan besar perhitungan sedimen secara aktual didapatkan nilai sebesar 2223,6 ton/tahun. Maka didapati hasil SDR (931,3 ton/tahun) < hasil aktual (2223,6 ton/tahun). Hal tersebut dikarenakan hasil perhitungan SDR menggunakan nilai erosi yang diperoleh dari metode USLE yang merupakan pendugaan laju erosi sedangkan dalam perhitungan sedimentasi aktual berdasarkan dari perhitungan secara langsung dan hasil laboratorium PT. Kaltim Prima Coal.
Studi Simulasi Pemberian Air Irigasi di Daerah Irigasi Kedungrejo
Authors: Novita Ayunda Eka , Soetopo Widandi - , Sayekti Rini Wahyu 
Published: December 2022

Daerah Irigasi Kedungrejo merupakan Daerah Irigasi lintas, yakni maksudnya adalah daerah irigasi yang mengaliri lebih dari satu kabupaten.. Daerah Irigasi Kedungrejo mengaliri luas baku sawah sebesar 1538 Ha. Dengan jumlah luas baku sawah yang cukup besar serta tidak sesuainya antara kebutuhan air irigasi dengan pemberian air irigasi menyebabkan sering terjadi kekurangan pada musim kemarau. Berdasarkan permasalahan diatas, perlu adanya evaluasi sistem pemberian air irigasi di daerah tersebut dan salah satu caranya adalah dengan metode indeks penggunaan air (IPA). Dengan melakukan simulasi indeks penggunaan air (IPA) didapatkan nilai IPA yang efisien serta nilai K yang dapat digunakan sebagai dasar dalam pemberian air irigasi di Daerah Irigasi Kedungrejo. Dari hasil simulasi IPA pada musim kemarau II didapatkan bahwa dengan mencoba-coba nilai IPA = 0,5 (kategori Baik) mendapatkan hasil nilai K, sebesar 0,74 (Giliran) pada intake dan perlu dibuatlah pembagian jadwal rotasi/ giliran yang terbagi menjadi III peiode yaitu periode I (Gol.I + Gol.IIÂ ) sebanyak 107 Jam, periode II (Gol.I + Gol.III) sebanyak 82 Jam dan periode III (Gol.II + Gol.III) sebanyak 51 Jam
Penentuan Skala Prioritas Kondisi Fisik Jaringan Irigasi pada Daerah Irigasi Selokambang & Daerah Irigasi Sumber Gogosan di Kabupaten Lumajang dengan Metode Analytic Hierarchy Process (AHP) dan Metode Analytic Network Process (ANP)
Authors: Nugroho Bimantio Fariz , Wahyuni Sri , Prayogo Tri Budi 
Published: December 2022

Daerah Irigasi Selokambang dan Daerah Irigasi Sumber Gogosan yang berlokasi di Kabupaten Lumajang termasuk ke dalam Daerah Irigasi yang menjadi program rehabilitasi oleh Pemerintah, kondisi fisik yang ada pada kedua Daerah Irigasi ini terjadi banyak kerusakan pada saluran dan bangunannya. Tujuan penelitian ini untuk mengetahui urutan skala prioritas fisik irigasi agar rehabilitasi yang dilakukan efektif dan efisien. Urutan skala prioritas didapatkan dengan menggunakan metode Analytic Hierarchy Process (AHP) dan Analytic Network Process (ANP). Hasil dari penelitian ini didapatkanÂ urutan skala prioritas yang sama dari kedua metode yaitu berdasarkan kriteria didapatkan urutan pertama adalah Bangunan Utama, dilanjutkan oleh Saluran Pembawa, dan Bangunan pada Saluran Pembawa. Berdasarkan alternatif didapatkan urutan pertama adalah Daerah Irigasi Sumber Gogosan, dan selanjutnya adalah Daerah Irigasi Selokambang. Bangunan terpilih yang menjadi prioritas adalah Bangunan Utama pada Daerah Irigasi Sumber Gogosan dengan perkiraan biaya rehabilitasi sebesar Rp 135.100.000,00.
Kajian Hidrolika Bendung Gerak Karangnongko Kabupaten Bojonegoro
Authors: Nisa Anggie Aqidahtun , Marsudi Suwanto , Dermawan Very 
Published: December 2022

Pembangunan Bendung Gerak Karangnongko bertujuan untuk mengendalikan banjir dan pengelolaan sumber daya air Sungai Bengawan Solo. Sebagai proyek nasional yang mempunyai fungsi startegis dan bernilai ekonomi tinggi maka diperlukan uji laboratorium untuk menganalisa desain berdasarkan aspek hidrolik dengan uji model fisik. Selain itu juga perlu mempelajari perilaku hidrolika secara analitis sehingga diperoleh rumusan yang mendekati hasil uji model. Penelitian ini memiliki tujuan (1) mengetahui kapasitas saluran pengelak dan perilaku hidrolika yang terjadi, (2) mencari bukaan barrage yang sesuai untuk mengendalikan tinggi muka air hulu rencana, (3) mengetahui perilaku hidrolik Bendung Gerak Karangnongko sehingga didapatkan rekomendasi penyempurnaan desain, dan (4) mengetahui gerusan di bagian hilir dan menentukan rekomendasi bangunan pengaman yang tepat. Berdasarkan hasil kajian diperoleh bahwa saluran pengelak mampu mengalirkan debit Q20th dengan aman, pengoperasian 9 pintu dibuka rata Â menunjukkan kondisi hidrolik terbaik , dan gerusan yang terjadi cukup dalam 5,16 m sehingga perlu menambahkan panjang blok beton yang semula 50 m menjadi 200 m.
Studi Perbandingan Model Horton dan Model Philip Terhadap Karakteristik Laju Infiltrasi
Authors: Pramestiningrum Novita , Harisuseno Donny , Fidari Jadfan Sidqi 
Published: December 2022

DAS Lesti, Kabupaten Malang mengalami alih fungsi lahan yang besar akibat pesatnya pembangunan di era modern ini sehingga Â mempengaruhi laju infiltrasi. Studi ini ditujukan guna mengetahui besar laju infiltrasi dengan Model Horton dan Model Philip, kemudian didapatkan model yang memiliki prediksi paling sesuai dengan pengukuran di lapangan. Pengambilan data infiltrasi berupa hubungan antara waktu dan besarnya penurunan air di titik-titik pengukuran menggunakan alat Double Ring Infiltrometer, kemudian nilai laju infiltrasi dihitung dengan Model Horton dan Model Philip, setelah itu dilakukan uji validasi menggunakan NSE, Koefisien Determinasi, Kesalahan Relatif, MAE dan RMSE. Hasil pengukuran yang dilakukan pada empat jenis tanah di DAS Lesti didapatkan laju infiltrasi awal tertinggi dengan nilai 15,0 mm/menit yaitu pada titik 4 dan titik 11, sedangkan nilai terendah sebesar 4,00 mm/menit pada titik 12. Dari perhitungan laju infiltrasi dengan Model Horton dan Philip didapatkan bahwa Model Horton memiliki kesesuaian yang baik terhadap lapangan sehingga Model Horton lebih dipilih untuk mengestimasi laju infiltrasi pada daerah studi.
Studi Optimasi Pemanfaatan Air Irigasi Pada Daerah Irigasi Kedungrejo Kabupaten Madiun Menggunakan Program Linier
Authors: Rahman Danang Nur , Sayekti Rini Wahyu , Ismoyo M Janu 
Published: December 2022

Daerah Irigasi Kedungrejo merupakan suatu kawasan yang termasuk dalam daerah irigasi, berada di Desa Wonoayu, Kecamatan Pilangkenceng, Kabupaten Madiun, Jawa Timur yang sering mengalami defisit air. Penelitian ini mengkaji tentang optimalisasi dalam memanfaatkan air guna kebutuhan irigasi di wilayah Irigasi Kedungrejo. Peneliti menggunakan metode program linier dengan bantuan solver dalam menganalisis optimasi pemanfaatan air. Fungsi tujuan optimasi ini adalah intensitas tanam dan keuntungan maksimum, dengan fungsi kendala Â luas lahan dan debit tersedia. Selain pola tanam eksisting, terdapat empat rencana alternatif dalam pola Â tanamnya. Dari analisis debit andalan yang telah dilakukan, penulis memilih debit andalan 80% karena nilai presentase dari debit tersebut mampu mendekati/mewakili debit yang terdapat pada Daerah Irigasi Kedungrejo dalam kurun waktu 10 tahun terakhir. Berdasarkan hasil optimasi dengan solver, peneliti mendapatkan hasil bahwa untuk kondisi debit andalan 80% sesuai dengan pola Â tanam alternatif 4, dimana penulis mendapatkan hasil intensitas tanam selamaÂ kurun waktu satu tahun sebesar 230,52 % dan mendapatkan laba dari produksi pertanian sebesar Rp. 70.231.727.974 . MT 1Â Keuntungan sebesar Rp. 42.145.036.560,-Â MT 2Â Keuntungan sebesar Rp. 22.020.742.374,- MT 3 : Keuntungan sebesar Rp. 6.065.949.040,-. Untuk Intensitas tanam MT 1 dan MT 2 sebesar 100% sedangkan untuk MT 3 sebesar 30,52%.
Магнитные переходы и разные валентные состояния ионов марганца в твердых растворах (Ni,Cu,Mn)-=SUB=-3-=/SUB=-BO-=SUB=-5-=/SUB=-
Authors: Софронова С.Н. , Еремин Е.В. , Велигжанин А.А. , Чернышов А.В. , Карташев А.В. , Великанов Д.А. 
Published: December 2022

Методами спектроскопии EXAFS и XANES были оценены содержание металлических ионов и их валентное состояние для трех составов NixCuyMn3-x-yBO5. Во всех трех составах содержание меди y не превысило 0.25; в третьем составе часть ионов марганца вошли в соединение не только в трехвалентном, но и в двухвалентном состоянии. Подробное исследование магнитных свойств показало, что во всех составах наблюдается два магнитных перехода: один в районе 60-75 K, а второй в районе 10 K. На основании вычисленных в рамках эмпирической модели обменных взаимодействий были определены температуры магнитного упорядочения для двух- и трехподрешеточного магнетика и сделано предположение, что магнитный переход в районе 60-75 K связан с упорядочением магнитных моментов в позициях 2 и 3. Ключевые слова: людвигиты, магнитный фазовый переход, косвенные обменные взаимодействия.
Hope and psychological well-being after 5 years become breast cancer survivors: a Qualitative Study
Authors: Werdani Yesiana Dwi Wahyu , Prasetya Arief Widya 
Published: December 2022

<p align="center"><strong> </strong></p><p><strong><em>Background:</em></strong><em> Cancer is perceived as a deadly disease for most people, it will affect the hope and psychological well-being of long-term cancer survivors. </em></p><p><strong><em>Objectives:</em></strong><em> This study aimed to explore changes in hope and psychological well-being after 5 years become breast cancer survivors. </em></p><p><strong><em>Methods:</em></strong><em> This was a qualitative study </em><em>with a phenomenological design. Samples were 23 breast cancer survivors in three health centers in Surabaya Indonesia taken by purposive sampling technique based on inclusion criteria. An in-depth interview was done when collecting the data. The interview was recorded with the permission of the participants. The data were inductively analyzed through conventional content analysis. </em></p><p><strong><em>Results:</em></strong><em> The participant has an age range of 41 – 70 years old, and most of them are no longer working since being diagnosed with cancer. This study found 4 themes consisting of the first theme was positive hope about cancer with 3 sub-themes:</em><em> h</em><em>ope to recover</em><em>, h</em><em>ope no recurrence occurs, and </em><em>h</em><em>ope to be healthier, the second theme was a good future with 3 sub-themes: long life, back to work, and optimism, the third theme was positive psychological well-being with 3 sub-themes: positive thinking, self-control ability, happy feeling, the last theme was a close relationship with God with 2 sub-themes: grateful and pray, repentance. </em></p><p><strong><em>Conclusions:</em></strong><em> Breast cancer survivors who have been diagnosed for more than 5 years and have completed cancer therapy had a positive hope to recover, are optimistic about the future and are closer to God, this encourages the achievement of positive psychological well-being</em><em>.</em></p>
Unintended pregnancy and antenatal care behavior in Indonesia
Authors: Widowati Lorensia Panselina , Damayanti Rita 
Published: December 2022

<p><strong><em>Background: </em></strong><em>One in four mothers experience u</em><em>nwanted pregnancy. It causes great risks for mothers and children, such as malnutrition, neglected, violence and even death. During pregnancy, a woman is expected to take the initiative and change her behavior by taking adequate care. Antenatal care is a part of maternal and child health services that are vital in early detection and monitoring of fetal well-being as an efforts to improve the health of mothers and babies during pregnancy, childbirth and postpartum. The mother's intention towards her pregnancy, whether desired or not, is related to the mother's behavior during pregnancy. Unintended pregnancy can obstruct the achievement of adequate antenatal care.</em><em>.</em></p><p><strong><em>Objectives: </em></strong><em>This study aims to determine the relationship between unintended pregnancy and antenatal care behavior</em></p><p><strong><em>Methods: </em></strong><em>This study used a cross-sectional design with the secondary data from 2017 Indonesian Demographic Health Survey. The dependent variable in this study was antenatal care behavior which is a composite of the first antenatal visit, frequency of antenatal visit and iron consumption. There were 14.223 women of childbearing age 15-49 years which eligible for this study’s criteria. The collected data was analyzed with chi square and logistic regression models of risk factors test</em><em></em></p><p><strong><em>Results:</em></strong><em> Mothers with unintended pregnancies have a bigger opportunity to do unhealthy antenatal care behavior (OR = 2.338: 95% CI 1.707- 3.203) compared to intended pregnancies. The effect of unintended pregnancy on antenatal care behavior varies according to maternal age (OR- 1.267: 95% CI 1.034-1.553), parity (OR= 0.579: 95% CI 0.430-0.780) and residency (OR= 1.490: 95% CI 1.226- 1.811).</em><em></em></p><p><strong><em>Conclusions: </em></strong><em>There is a relationship between unintended pregnancy and antenatal care behavior. Mothers with unintended pregnancies is 2.338 times more likely to have unhealthy antenatal behavior care. We also found that this effect differs according to the maternal age, parity and residency.</em><em> </em><em></em></p>