bluuebunny/crossref_metadata_2025_split huggingface dataset:
A risk-based model for allocating post-earthquake reconstruction finance in medium-size Iranian Cities
Authors: Kazemiasl Niloofar , Motamed Hooman , Fazlavi Mohsen 
Published: January 2025

Abstract

Introduction and Background
This study explores effective strategies for allocating financial resources in postearthquake urban reconstruction. Given the financial complexities of such projects, it is essential to have a structured plan to identify challenges and address potential gaps. The research underscores the importance of predisaster planning in managing financial resources efficiently.

Methodology
District 2 of Tehran municipality was chosen as the case study due to its significant risk exposure and vulnerability, making it a suitable representation of a medium-sized urban area. The study includes two key components: seismic risk assessment and financial resource allocation. Seismic risk was modeled using computational methods and risk analysis techniques. Strategies for budget allocation were formulated based on insights from interviews, historical case studies, and computational modeling.

Results
Scenarios ranging from optimistic to pessimistic were analyzed to assess their impact on reconstruction timelines. Results show that reconstruction for an urban area like District 2 could be completed in 4.3 years in the optimistic scenario, 9.2 years in the probable scenario, and 11.3 years in the pessimistic scenario.

Conclusion
The study reveals that efficient resource allocation minimizes delays, while insufficient planning significantly prolongs recovery. These findings demonstrate the importance of pre-disaster planning and effective resource allocation in expediting recovery and improving resilience in medium-sized cities.
On Your Mark, Get Set, Choose! A Randomized Cross-Over Study Comparing Fixed and Self-Selected Rest Periods in Interval Running Among Professional Female Soccer Players
Authors: Ben-Ari Asaf , Silverman Yedidya , Obolski Uri , Halperin Israel 
Published: January 2025

Abstract

Background
Studies on rest durations during high-intensity interval training (HIIT) often compare fixed and self-selected (SS) rest allocation approaches. Frequently, the rest duration under SS conditions is unlimited, leading to inconsistent total rest durations compared to fixed rest conditions. To address this limitation, we recently compared fixed and SS rest conditions during cycling HIIT sessions, while keeping the total rest duration equivalent. However, our protocol required athletes to divide a long total rest duration (720 s) across nine intervals, which may have been overly cognitively demanding. The current study aimed to explore the effects of the SS approach with a simplified rest allocation task on performance, physiological, and psychological outcomes.

Methods
Following a familiarization session, 24 professional female soccer players completed two running HIIT sessions on a non-motorized treadmill. Each session consisted of twelve 15 s intervals, divided into three blocks, with the goal of maximizing the distance covered. In both conditions, the between-interval rest duration per block amounted to 270 s. In the fixed condition, the rest was uniformly allocated to 90 s between each interval, whereas in the SS condition, the athletes chose how to allocate the entirety of the 270 s of rest. We compared the following outcomes: distance, heart rate, perception of fatigue, effort, autonomy, enjoyment, boredom, and athletes’ preferences. Outcomes were compared using aggregated measures via paired univariate tests, and across the intervals via mixed-effects models.

Results
We observed comparable results in most outcomes with the exception of higher autonomy (1–15 points) in the SS condition (mean difference = 2.1, 95%CI (0.9, 3.3) points) and a negligibly higher heart rate in the SS condition when comparing the observations across intervals (estimate = 2.5, 95%CI (0.9, 4.2) beats × min−1). Additionally, participants chose to rest for longer durations as the block progressed. Finally, the majority of participants (65%) favored the SS condition.

Conclusion
This study further solidifies that SS and fixed approaches with matched total rest durations result in similar performance, physiological, and psychological responses. This effect persists even when the total rest duration required to be allocated is relatively short. Therefore, coaches and trainees can choose either approach based on their preferences and training goals.
Presence of the Anopheles culicifacies complex species A in southeast Iran
Authors: Madjdzadeh Seyed Massoud , Behi Nahid , Gorouhi Mohammad Amin , Amirkafi Arsalan , Oshaghi Mohammad Ali 
Published: January 2025

Abstract

Background
The Anopheles culicifacies complex is one of the most important malaria vectors in Southeast Asia and Southeastern Iran. Although the sibling species within this complex are morphologically indistinguishable, they differ significantly in their disease transmission potential, blood-feeding behaviour, and other biological traits. Cytogenetic and chromosomal studies have identified five sibling species within this complex: A, B, C, D, and E. Understanding the species composition and distribution of this complex is crucial for malaria control strategies.

Objectives
This study aimed to identify the sibling species of the An. culicifacies complex in Qaleh Ganj County, Kerman Province, Southeastern Iran. Specifically, the study sought to determine the presence of species A, which is known to be a primary vector of malaria in the region.

Methods
We employed allele-specific PCR and sequencing PCR techniques to identify the sibling species. DNA was extracted from mosquito specimens, and the D3 region of the 28S rDNA gene and a segment of the COII gene from the mitochondrial genome (mtDNA) were targeted for amplification and sequencing.

Results
Data analysis revealed a positive correlation between An. culicifacies s.l. specimens and altitude, with most specimens collected from mountainous areas. Both allele-specific PCR and sequencing PCR confirmed the presence of species A in the study areas of Kerman Province.

Conclusions
Given that species A is a primary malaria vector, the findings of this study provide valuable insights for guiding malaria control strategies in Southeastern Iran. Further studies are recommended to assess the vector competence and ecological dynamics of other species within the An. culicifacies complex in the region.
Volatile organic compounds of hoary stock are responsible for suppressing downy mildew of grape in an intercropping system
Authors: Deng Weiping , Du Fei , Yang Rongliang , Yao Hanyang , Yang Min , Mei Xinyue , Ye Chen , Li Su , Liu Yixiang , Huang Huichuan , Zhu Shusheng 
Published: January 2025

Abstract
Grape downy mildew (Plasmopara viticola) is an air-borne disease and difficult to control. It has been observed that intercropping grapevines (Vitis vinifera) with aromatic plants can effectively suppress the airborne disease and volatile organic compounds (VOCs) from the aromatic plants are believed to have antimicrobial activities. In this study, a two-year field trial was established by intercropping grapevine and hoary stock (Matthiola incana) to evaluate the control of grape downy mildew. The field results showed that intercropping effectively suppressed grape downy mildew, particularly during the blooming stage of hoary stock. VOCs from hoary stock plants exhibited a dosage-dependent antimicrobial activity against grape downy mildew. To examine the role of VOCs, hoary stock plants were grown in an enclosed chamber, and VOCs were collected at the time points before and post blooming. The collected VOCs were subjected to gas chromatography-mass spectrometry (GC–MS) analysis and in vitro bioassays. Twenty-four VOCs found from pre-blooming and 36 VOCs from post-blooming hoary stock plants were identified. Seventeen VOCs demonstrated consistent inhibitory activities against P. viticola, including seven terpenoids, five benzenoids, and five aliphatics. Among the 17 VOCs, five were unique to post-blooming hoary stock, while 12 were common to both pre- and post-blooming hoary stock. The antimicrobial VOCs offers a potential eco-friendly alternative to managing downy mildew.
Risk factors of recurrent periprosthetic joint infection of the knee after two-stage reimplantation
Authors: Lee Do Weon , Han Hyuk-Soo , Ro Du Hyun 
Published: January 2025

Abstract

Introduction
Prosthetic joint infection (PJI) is one of the most common and detrimental complications of total knee replacement arthroplasty (TKA). Despite extensive efforts, including two-stage reimplantation, to eradicate PJI, it still recurs in a substantial number of patients. However, the risk factors of recurrence after two-stage reimplantation of the knee have not been established. In this study, it is hypothesized that there will be certain risk factors of recurrence after two-stage reimplantation for PJI of the knee.

Materials and methods
From March 2002 to December 2022, 65 knees that underwent two-stage reimplantation for PJIs in a single, tertiary hospital were retrospectively reviewed, and 44 patient-related, laboratory-related, and surgery-related factors, including body mass index, pathogen type, and the usage of transfusions, were selected as the potential risk factors for recurrence. Survival analysis using the Kaplan–Meier method and subsequent Cox proportional hazard regression were performed.

Results
Out of the 65 knees that underwent two-stage reimplantation, infection recurred in 15 knees (23.1%) in a median 11 (range 4–108) months. The Cox proportional hazards regression showed that infection of revision TKA, mixed pathogen-type infection, and higher serum erythrocyte sedimentation rate (ESR, mm/h) level increases the risk of recurrence (p-values < 0.001, 0.04, and 0.009; hazard ratios 40.29, 1.53, and 1.03, respectively).

Conclusions
A significant portion of PJI of the knees recurred after two-stage reimplantation. Revision TKA at the time of initial PJI, mixed pathogen-type infection, and higher serum ESR level were three significant risk factors of PJI recurrence. Surgeons should be more cautious in suspecting PJI relapse for these specific occasions.

Level of evidence
III, retrospective cohort study.
Vertebral Column Subluxation in Neurofibromatosis Type 1–Associated Dystrophic Scoliosis: A Report of Two Cases and Narrative Review
Authors: Dastagirzada Yosef , Neifert Sean , Kurland David B. , Kim Nora C. , Panicucci-Roma Tania , Frempong-Boadu Anthony , Lau Darryl 
Published: January 2025

BACKGROUND AND OBJECTIVE:
Neurofibromatosis-1 (NF1) dystrophic scoliosis is a challenging disease to manage surgically, with multiplanar curves progressing rapidly and unpredictably. Conservative management with bracing is often unsuccessful, and many patients necessitate instrumented fusion to halt progression of their curves. In rare cases, patients can present with spontaneous vertebral subluxation, significantly complicating the surgical management of this already complex disease process. The objective here was to describe 2 cases of vertebral subluxation in NF1-associated dystrophic scoliosis along with their surgical corrections and clinical courses.

METHODS:
A retrospective review of 2 cases at the authors' institution was performed to describe their preoperative symptom complexes, surgical corrections, and postoperative courses. A narrative review of the literature surrounding NF1-associated dystrophic scoliosis and subluxation is also presented.

RESULTS:
Two cases of vertebral subluxation at T4-5 and C7-T1 are presented. Both patients had significant dystrophic features throughout their spines, and halo-gravity traction was unsuccessful in 1 patient and led to vertebral and subclavian artery injuries in the other. One patient underwent an uncomplicated deformity correction with partial vertebral column resection to facilitate his deformity correction. The other patient, after her vascular injuries, ultimately suffered a spinal cord injury after a fall and underwent emergent instrumentation, decompression, and partial vertebral column resection at the site of subluxation, with improvement in her neurological function afterward.

CONCLUSION:
Dystrophic scoliosis in NF1 remains a difficult disease to treat, and deformity correction in patients with subluxation is particularly complex. These cases here highlight the unpredictability and possible complications of halo-gravity traction, need for good fixation to facilitate subluxation reduction, high chance of hardware complications and proximal or distal failure, and importance of cooperative management of these patients in conjunction with other surgical services.
Predictors of Bilateral Disease in Low-Risk Papillary Thyroid Cancer: Histopathologic Insights and Preoperative Ultrasonography
Authors: Rodriguez Schaap P. M. , Papachristos A. , Serrao-Brown H. , Aniss A. , van Dijkum E. J. M. Nieveen , Gill A. J. , Delbridge L. , Engelsman A. F. , Sidhu S. , Sywak M. 
Published: January 2025

Abstract

Background
With the current shift toward de-escalation of surgical management in low-risk papillary thyroid cancer (PTC), understanding predictors and the clinical significance of additional tumors in the contralateral lobe is important. This study investigated the histopathologic predictors of bilateral disease in low-risk PTC patients and the utility of preoperative ultrasonography in guiding completion thyroidectomy decisions.

Methods
Patients treated with total thyroidectomy (TT) for low-risk PTCs (< 4 cm) at the Endocrine Surgical Unit of the Royal North Shore Hospital, University of Sydney from 2013 to 2020 were identified from a prospectively maintained database. The primary objective was to evaluate whether specific histopathologic factors can reliably predict the likelihood of bilateral disease in low-risk PTC patients after hemithyroidectomy. The secondary objective was to assess the accuracy of preoperative ultrasonography for patients with bilateral disease.

Results
Of the 737 patients in this study, 194 (26.3%) had bilateral disease. The multivariate analysis showed that larger median tumor size (odds ratio [OR] 1.043 per mm; 95 % confidence interval [CI] 1.025–1.062; P < 0.001), ipsilateral multifocal disease (MFD) (OR 2.010; 95% CI 1.338–3.020; P < 0.001), and venous invasion (OR 1.693; 95% CI 1.058–2.707) had a significant association with bilateral disease. However, in the prediction of clinically significant contralateral disease (≥ 10 mm), median tumor size (OR 1.104 per mm; 95% CI 1.059–1.152; P < 0.001) and venous invasion (OR 2.815; 95% CI 1.044–7.589; P = 0.041) were significantly correlated, whereas ipsilateral MFD lost its significance. These significant contralateral tumors were identified preoperatively and associated with higher Thyroid Imaging, Reporting and Data System (TIRADS) and/or Bethesda cytology classifications in 94% of cases.

Conclusion
In low-risk PTC patients, larger tumor size, venous invasion, and ipsilateral MFD are significantly associated with disease in the contralateral thyroid lobe.
Role of mycelia derived from in vitro cultures of Amanita spp. as a potential source of bioactive compounds with therapeutic potential for the mitigation and management of depressive disorders
Authors: Kała Katarzyna , Sułkowska-Ziaja Katarzyna , Piotrowska Joanna , Gajda Marta , Sękara Agnieszka , Hnatyk Kamil , Lazur Jan , Muszyńska Bożena 
Published: January 2025

Cel pracyGrzyby z rodzaju Amanita są uważane za jedne z najbardziej toksycznych, powodujących poważne zatrucia, często kończące się śmiercią. Jednakże, spośród 707 opisanych gatunków, jedynie kilkanaście zawiera toksyczne oktapeptydy sklasyfikowane jako amanitotoksyny i falotoksyny. Większość przedstawicieli tego rodzaju uznana jest za gatunki niejadalne, nieliczne z kolei to przykłady smacznych gatunków jadalnych. Amanita muscaria i Amanita pantherina to gatunki trujące mające znaczący etnomykologiczny wpływ na ewolucję i socjologię człowieka między innymi ze względu na działanie psychoaktywne.
Celem pracy było uzyskanie w warunkach laboratoryjnych myceliów dwóch gatunków A. muscaria i A. pantherina z wykorzystaniem 10 L bioreaktorów z systemem air-lift oraz ocena uzyskanego materiału grzybowego jako surowca farmaceutycznego zawierającego muscymol oraz inne związki biologicznie aktywne o potencjalnym znaczeniu w profilaktyce depresji.MetodaOtrzymaną biomasę analizowano metodą RP–HPLC oraz ASA pod względem zawartości związków organicznych (związki indolowe, sterole, lowastatyna, ergotioneina, muscymol, kwas ibotenowy) i biopierwiastków.WynikiNa podstawie otrzymanych rezultatów można wnioskować, że mycelium A. muscaria zawiera szereg związków bioaktywnych takich jak lowastatyna, ergotioneina czy 5-hydroksy-L-tryptofan w wyższych zawartościach niż A. pantherina.WnioskiPrzeprowadzone w pracy oznaczenia muscymolu i innych dotąd nieanalizowanych substancji bioaktywnych w biomasie otrzymanej w warunkach in vitro oraz porównawczo w owocnikach mogą przyczynić się do wykazania potencjału tych gatunków w leczeniu depresji, jednak konieczne są dalsze badania eksperymentalne, w tym próby in vitro, a następnie badania kliniczne.
Convertible metal-backed glenoid in total shoulder arthroplasty
Authors: Ranieri Riccardo , Borroni Mario , Delle Rose Giacomo , Conti Marco , Garofalo Raffaele , Castagna Alessandro 
Published: January 2025

AimsThe aim of this study was to report long-term clinical outcomes of a modern convertible metal-backed glenoid (MBG) in total shoulder arthroplasty (TSA).MethodsAfter a minimum of 15 years, a previously studied cohort of 35 patients who received a modern convertible MBG during the period 1996 to 2005 was contacted for clinical and radiological follow-up. At last follow-up, patients were evaluated radiologically and clinically according to the Constant Score, Simple Shoulder Test, and visual analogue scale for pain. Complications and revisions were recorded, and survival analysis was performed.ResultsAt the last follow-up, 20 patients were contacted. Of these, 15 patients had experienced at least one complication, and ten underwent revision surgery. The mean time to revision was 13.8 years (7 to 20). Cuff failure was the most common complication. Conversion to reverse shoulder arthroplasty, while maintaining the baseplate, was possible in five cases, with good results. In patients in whom the baseplate was removed, revision was performed significantly later (18.4 vs 11.1 years; p = 0.016). The general revision-free survival was 73% (95% CI 49.5 to 87.3) at 15 years and 38% (95% CI 11.8% to 64.3%) at 20 years, while MBG revision-free survival was 96.0% (95% CI 74.8% to 99.4%) at 15 years and 54% (95% CI 16.2% to 80.8%) at 20 years. Clinical scores showed a negative trend over time, although not statistically significant. Radiologically, polyethylene wear was observed in all cases and was complete in 12 out of 19 cases, and five glenoids were ‘at risk’ for loosening.ConclusionAt long-term follow-up, convertible MBG-TSA revealed a high rate of complications and revision surgery, mainly due to soft-tissue failure and polyethylene wear occurring with time. Prompt conversion to RSA maintaining the baseplate provided good results and a low complication rate. Radiological follow-up at about ten years is strictly recommended and, if metal-to-metal contact is observed, conversion to RSA is advisable. These results emphasize the need for continued research into improving TSA outcomes, especially in cases of MBG usage.Cite this article: Bone Jt Open 2025;6(1):82–92.
Synthesis of single-cycle pulses based on a Yb:KGW laser amplifier
Authors: Pi Z. , Kim H. Y. , Goulielmakis E. 
Published: January 2025

Yb:KGW lasers have been gaining increasing importance in ultrafast and
strong-field physics, but their compression to the single- and
sub-cycle regime remains a challenge. Here, we utilized a dual
hollow-core fiber module for the spectral broadening of Yb:KGW pulses
to more than 3.5 optical octaves, from the short-wave infrared () to vacuum ultraviolet (). A light-field synthesizer
compressed a large portion of this bandwidth (380–1000 nm) to
single-cycle pulses, based on Yb:KGW technology. Our work opens the
door to attaining new regimes of control and temporal compression of
light pulses and their advanced applications in ultrafast
spectroscopy.
Fracture-healing effects of Rhizoma Musae ethanolic extract: An integrated study using UHPLC-Q-Exactive-MS/MS, network pharmacology, and molecular docking
Authors: Zhang Jian , Shen Wanyan , Liu Fanzhi , He Hehe , Han Shuquan , Luo Lina 
Published: January 2025

Background
Fracture disrupts the integrity and continuity of the bone, leading to symptoms such as pain, tenderness, swelling, and bruising. Rhizoma Musae is a medicinal material frequently utilized in the Miao ethnic region of Guizhou Province, China. However, its specific mechanism of action in treating fractures remains unknown. This study aimed to elucidate the chemical constituents of the ethanol extract of Rhizoma Musae (EERM) and investigate its fracture-healing mechanism using network pharmacology.

Methods
The chemical profile of EERM was characterized via UHPLC-Q-Exactive-MS/MS. Subsequently, a comprehensive network of compounds, targets, and pathways was constructed using network pharmacology approaches. The interactions between the active compounds of EERM and their targets were validated through molecular docking, molecular dynamics simulation and in vitro cell experiments.

Results
EERM contained 522 identified compounds. Topological analysis of the protein-protein interaction (PPI) network identified 59 core targets, including key proteins like AKT1, IL-6, and EGFR, known for their anti-inflammatory properties and ability to enhance bone cell proliferation and differentiation. Gene Ontology analysis indicated the involvement of EERM in biological processes such as peptidyl-serine phosphorylation, response to xenobiotic stimulus, and nutrient level regulation. KEGG analysis suggested that EERM’s mechanism may involve signaling pathways such as PI3K-Akt, lipid and atherosclerosis, EGFR tyrosine kinase inhibitor resistance, and MAPK pathways. Molecular docking and molecular dynamics simulations results demonstrated a strong binding affinity between the main compounds of EERM and key targets. In vitro cell experiments demonstrate that EERM enhances cell proliferation by upregulating the expression levels of EGFR and STAT3, while simultaneously downregulating AKT1 and CASP3.

Conclusion
This study investigates the potential active compounds of EERM and its key targets in regulating multiple pathways of fracture, leading to promoting bone cell proliferation. These results offer valuable insights for the future development and clinical application of Rhizoma Musae.