bluuebunny/crossref_metadata_2025_split huggingface dataset:
Design of a Conversational Recommender System in Education
Authors: Valtolina Stefano , Matamoros Ricardo Anibal , Battaglia Alberto , Mascari Michelangelo , Epifania Francesco 
Published: June 2023

Abstract
In recent years we have seen a significant proliferation of e-learning platforms. E-learning platforms allow teachers to create digital courses in a more effective and time-saving way, but several flaws hinder their actual success. One main problem is that teachers have difficulties finding and combining open-access learning materials matching their specific needs precisely when there are so many to choose from. This paper proposes a new strategy for creating digital courses that use learning objects (LOs) as primary elements. The idea consists of using an intelligent chatbot to assist teachers in their activities. Defined using RASA technology, the chatbot asks for information about the course the teacher has to create based on her/his profile and needs. It suggests the best LOs and how to combine them according to their prerequisites and outcomes. A chatbot-based recommendation system provides suggestions through BERT, a machine-learning model based on Transformers, to define the semantic similarity between the entered data and the LOs metadata. In addition, the chatbot also suggests how to combine the LOs into a final learning path. Finally, the paper presents some preliminary results about tests carried out by teachers in creating their digital courses.
SINKRONISASI PENGATURAN KEWENANGAN CABANG RUTAN BNN TERHADAP PP NOMOR 58 TAHUN 1999 DALAM KERANGKA SISTEM PEMASYARAKATAN
Authors: Soge Markus Marselinus 
Published: June 2023

The responsibility of organizing the correctional system includes the construction of inmates and the treatment of prisoners at the Directorate General of Corrections, but in practice, prisoners are not always in Rutan or Rutan Branch owned by Kemenkumham. BNN also manages Rutan Branch which is regulated in BNN Head Regulation No. 6 of 2016 concerning Prisoner Supervision. The problem here is how the synchronization level of the regulation of the authority of Rutan Branch of BNN against PP No.58 of 1999 within the framework of the correctional system. Normative legal research methods with legal approaches are used in this paper, and also used secondary data, namely primary and secondary legal materials. The data is collected by library study techniques, then qualitatively analyzed with legal interpretation. The results of the study are using guidelines for evaluation of legislation, especially table 3 assessment with variable 'authority' then the BNN Head Regulation No. 6 of 2016 is unsynchronized with PP No.58 of 1999 in the indicator 'there are arrangements about the same authority on 2 (two) or more regulations whose hierarchy is different, but the implementing agencies are different'. It is recommended that the Directorate General of Corrections of Kemenkumham can coordinate with BNN to discuss the unsynchronized of the authority arrangements of the Rutan Branch of BNN related to the supervision of prisoners to strengthen the implementation of the correctional system.
Comparative study of simple and modified rice husk biochar for cadmium removal: Adsorption performance and possible mechanisms
Authors: Gautam Kaushik , Gupta Neha , Patel Devendra Kumar , Singh Rajeev Pratap , Singh Anita 
Published: June 2023

Abstract

In the present study, the simple and chemically modified forms of biochar (KMnO4 and HNO3; 0.01 M) obtained from rice husks were used to study the possible mechanism behind the process of cadmium (Cd) adsorption from the synthetic solution having Cd2+ ranged from 10 to 50 ppm. At 50 ppm, the maximum adsorption has been observed and it showed 93% removal by the KMnO4 modification and 86% by HNO3 modification, whereas simple biochar led to 82% removal only. The adsorption pattern follows the Langmuir and pseudo-second-order model. With characterization techniques, it has been confirmed that the KMnO4-modified forms of biochar showed more adsorption capacity than HNO3-modified and simple biochar. Furthermore, to check its practical applicability, the modified forms of biochar have been applied to the wastewater collected from Banaras locomotive works, Bhagwanpur, and Lohta sites of Varanasi city, UP, India. Again, the maximum adsorption of Cd2+ has been observed with KMnO4 modification (92–95%) at all the sites. This result also confirmed that KMnO4 was the best modifying agent over HNO3. Therefore, its application could be promoted in metal-contaminated water and soil to decrease the availability of toxic metals.
Data management in life cycle assessment: a case study of wastewater treatment
Authors: Straub Julia , Hofmann Josef , Hehenberger-Risse Diana 
Published: June 2023

Abstract

To assess the environmental impact of wastewater treatment, life cycle assessment (LCA) is a frequently applied instrument. However, these studies often require large amounts of data. The complexity and heterogeneity of these data result in the need for a systematic data management approach. Especially the generation of the life cycle inventory (LCI) holds the potential to be facilitated by automation. A case study in the wastewater sector was used to demonstrate the implementation of data management. A database structure was developed to store the raw data of the wastewater plants (WWTPs) and make it accessible through code. The code interacted with the database, implemented calculations, and automatically created the inventory based on the processed data. The database provides a consistent structure for the raw data and can also be used for backup purposes. Because it is machine-readable it can be accessed through the code that enables the automated generation of the LCI. As a proof of concept, a sequence of the code is provided with a user interface and can be tested online. We found that for most use cases, basic programming tools were sufficient for systematic data management, and, therefore, the approach is considered accessible for LCA practitioners.
Abundance, characteristics, and removal of microplastics in the Cihu Lake-wetland microcosm system
Authors: Li Yuxiao , He Jiaqing , Li Yixin , Sun Zhiquan , Du Hao , Wang Dongliang , Zhang Peng , Li Haixiao 
Published: June 2023

Abstract

Sewage treatment plants (STPs) are significant routes through which microplastics (MPs) are released into the aquatic environment. Constructed wetland is an effective facility for deep treatment of tailwater. At present, research on the removal of MPs in the tailwater of STPs by multi-stage constructed wetlands is limited. This work investigated and analyzed the removal characteristics of MPs in the tailwater treatment system of Cihu wetland park in Huangshi, Hubei Province of China. The abundance/removal of MPs in the Cihu Lake-wetland microcosm system was investigated. The results showed that the multi-stage constructed wetlands achieved a total removal rate of 94.7% for MPs with 2.2 particles/L MPs in the effluent. The removal rates of MPs reached 89 and 37.5%, respectively, in the (horizontal/vertical) subsurface flow constructed wetland and surface flow constructed wetland. The abundance of MPs in receiving water of Cihu Lake substantially decreased due to the dilution of wetland effluents. This study partially bridged the knowledge gap hypothesis on the treatment of MPs in tailwater by multi-stage constructed wetlands.
sujeito pronominal e a gramática comunicativa
Authors: Delamar José Volpato Dutra  , Jovino Pizzi  
Published: June 2023

PIZZI, Jovino; DUTRA, Delamar José Volpato. O sujeito pronominal e a gramática comunicativa: elementos para uma gramática da justiça. In: COLÓQUIO HABERMAS, 11.; COLÓQUIO DE FILOSOFIA DA INFORMAÇÃO, 2., 2015. Rio de Janeiro. Anais [...] Rio de Janeiro: Salute, 2016. Disponível em: https://coloquiohabermas.files. wordpress.com/2016/03/anais-xi-coloquio-habermas-e-ii-coloquio-de-filosofia-da-informacao1.pdf. Acesso em: 25 abr. 2023.
Synthesis and Chemistry of 1,2,4,3-Triazaphosphole Derivatives
Authors: Ali Tarik E. , Hassanin Noha M. , Assiri Mohammed A. , Abdel-Kariem Somaia M. 
Published: June 2023

Abstract:
This review describes the progress made during the last fifty years in the synthesis
and chemistry of 1,2,4,3 triazaphospholes. This class of compounds has attracted tremendous homogeneous catalysis and interest in molecular materials science. These fascinating phosphorus
heterocycles have conjugated π systems with high degrees of aromaticity. 1,2,4,3-
Triazaphospholes can be designed through [3+2] cyclocondensation between functionalized
hydrazines with phosphonoimidates that allow the incorporation of additional donor substituents
into specific positions of the phosphorus heterocycle. In addition, [4+1] cyclocondensation
between functionalized amidrazones and active phosphorus reagents is the most synthetically
accessible method. The used strategies facilitated synthetic access to a completely
new set of triazaphospholes leading to a much broader scope for potential applications.
1,2,4,3-triazaphospholes displayed reactivity towards a variety of reagents. The phosphorus is particularly prone to
undergo oxidative 1,1-addition. Protic reagents such as alcohols, phenols, and amines can be added across the P=N
bond of 2H-1,2,4,3-triazaphospholes to yield the dihydro-1,2,4,3-triazaphosphole derivatives. 1H- and 2H-1,2,4,3-
triazaphospholes reacted with alcohols, ammonia and amines in the presence of sulfur or selenium to form dihydro-
1,2,4,3-triazaphosphole 3-chalcogenides. The appropriate difunctional reagents such as glycols, 2-azido alcohols
and phenol with a heterodiene function in the ortho position reacted with 2H-1,2,4,3-triazaphospholes to yield
products formed via 1,2-addition on P=N bond. Similar behavior is shown by 2-hydroxyacetophenone and 2-
hydroxy-benzophenone. 2H-1,2,4,3-Triazaphospholes reacted with acetylenes to form [3+2] cycloadducts; the latter
change to 1,2,3-diazaphospholes. [4+1] Cycloadditions occurred with α-diimines, azodicarboxylic esters, and
1,2-diketones; in the latter two cases, the resulting products dimerize.
Phytochemical and Pharmacological Potential ofFerula asafetida“Hing”
Authors: Singh Sonia , Shukla Arpit , Semwal Bhupesh C. 
Published: June 2023

Abstract:Asafoetida, also known as Hing, is a resinous gum derived from the roots of Ferula species, specifically Ferula asafetida. From ancient times, it has been employed both in the kitchen as a seasoning and in the practice of traditional medicine. In terms of pharmacognosy, asafoetida is comprised of a number of active chemicals, the most notable of which are coumarins, volatile oils (17%), and ferulic acid (60%). Ferulic acid and coumarins (40%) are two of the components that contribute to the medicinal value of this plant. The volatile oils are responsible for the strong odour and flavour of this plant. It is used for a variety of applications in the medical field. It is not only used as spices and condiments for the goal of imparting taste in curries, but it is also utilised in the treatment of gastrointestinal tract diseases, asthma, whooping cough, hypertension, and a variety of other conditions. The herb has been used to extract a variety of phytochemical components, including sesquiterpene coumarins, coumarins, diterpene coumarins, and chemicals containing sulphur. This manuscript provides a synopsis of the facts concerning the pharmacological activities and bioactive components of Ferula asafetida.
A Rationalized Approach to Design and Discover Novel Non-steroidal Derivatives through Computational Aid for the Treatment of Prostate Cancer
Authors: Kumar Shubham , Arora Pinky , Wadhwa Pankaj , Kaur Paranjeet 
Published: June 2023

Background:Prostate cancer is one of the most prevalent cancers in men, leading to the second most common cause of death in men. Despite the availability of multiple treatments, the prevalence of prostate cancer remains high. Steroidal antagonists are associated with poor bioavailability and side effects, while non-steroidal antagonists show serious side effects, such as gynecomastia. Therefore, there is a need for a potential candidate for the treatment of prostate cancer with better bioavailability, good therapeutic effects, and minimal side effects.Objective:This current research work focused on identifying a novel non-steroidal androgen receptor antagonist through computational tools, such as docking and in silico ADMET analysis.Methods:Molecules were designed based on a literature survey, followed by molecular docking of all designed compounds and ADMET analysis of the hit compounds.Results:A library of 600 non-steroidal derivatives (cis and trans) was designed, and molecular docking was performed in the active site of the androgen receptor (PDBID: 1Z95) using Auto- Dock Vina 1.5.6. Docking studies resulted in 15 potent hits, which were then subjected to ADME analysis using SwissADME. ADME analysis predicted three compounds (SK-79, SK-109, and SK-169) with the best ADME profile and better bioavailability. Toxicity studies using Protox-II were performed on the three best compounds (SK-79, SK-109, and SK-169), which predicted ideal toxicity for these lead compounds.Conclusion:This research work will provide ample opportunities to explore medicinal and computational research areas. It will facilitate the development of novel androgen receptor antagonists in future experimental studies.
Nanoemulsion based in-situ Gel for Ocular Delivery of Brimonidine Tartrate
Authors: Prajapati Bhupendra , Modi Chetna , Patel Uma , Kendre Prakash 
Published: June 2023

Background:
Brimonidine tartrate is currently used to treat glaucoma; however, conventional
ocular formulations have some disadvantages in terms of treating disorders like glaucoma, as
less than 5% of the drug reaches a posterior segment of the eye; hence, there is a need for sustained
treatment.

Objective:
The objective of this study was to develop a self-nanoemulsion (SNEDDS) in-situ gel of
brimonidine tartrate to investigate the sustained-release effect to improve ocular bioavailability.

Method:
Oil, surfactant, and co-surfactant were screened using the pseudo-ternary phase diagram
(TPD) by aqueous-titration method based on the drug solubility. Nanoemulsions were evaluated for
the pH, viscosity, % drug content, % transmittance, dispersibility, particle size, zeta-potential, TEM,
and conductivity test. Nanoemulsion was incorporated into in-situ gel and evaluated for gelling capacity,
pourability, gel strength, in vitro drug release study, and drug release kinetics.

Result:
Castor oil (10%) as oil phase, Acrysol K-140 (10%) as surfactant, and PEG 400 (20%) as cosurfactant
were selected in preparation of SNEDDS from TPD. Evaluation parameters of SNEDDS
were found in an acceptable range. % Drug release showed the controlled release up to 8 hrs. Optimum
% drug content and % CDR were 100.25% and 92.46% after 12hrs, respectively. Optimized
SNEDDS in-situ gel followed the Higuchi model via diffusion mechanism having 0.99 R² value and
exhibiting sustained release up to 12 hr. Stability study proved no significant changes during storage.
In vitro, the ocular irritancy test proved suitable for ocular delivery.

Conclusion:
A sustained-release formulation was obtained by developing brimonidine tartrate
SNEDDS in-situ gel as a stable formulation without irritancy during ocular administration.
Flow Diversion for the Management of Posterior Circulation’s
Intracranial Aneurysms
Authors: Adamou Antonis , Alektoroff Kirill , Politi Maria , Alexandrou Maria , Roth Christian , Papanagiotou Panagiotis 
Published: June 2023

:
The endovascular treatment of posterior circulation aneurysms, although challenging, has
been well-established due to various factors that limit the surgical approach in most cases. Flow diversion
has also been utilized in the treatment of such aneurysms, although its effectiveness and safety
still require evaluation. Numerous studies have examined the outcomes and complication rates in patients
treated with FD, resulting in varying findings. This review aimed to summarize the most recent
literature concerning the effectiveness of flow diversion devices in posterior circulation aneurysms.
Additionally, it highlights reports that compare results in the posterior versus anterior circulation, as
well as flow diversion versus stent-assisted coiling.
A Comprehensive Mini Review on the Natural Product Bacopa monnieri
for the Management of Alzheimer’s Disease
Authors: Jain Naman , Tambekar Omkar , Goel Tanvi , Bodhankar Subhash Laxmanrao , Bansode Deepali Amol 
Published: June 2023

Abstract:
Central nervous system disorders are expected to profoundly impact the global healthcare needs
of the human community in this era. Senile decay of neurons is (Alzheimers Disease) AD. The hallmark of
the pathophysiology of AD disease has two pivotal features: extracellular beta-amyloid deposition and intracellular
tau hyperphosphorylation. New medicine-based psychoactive treatments have met with modest effectiveness
due to the multifactorial nature of these diseases. As a result, there is an increasing need for new
products that can address various receptors and enhance behavioral abilities independently or in tandem with
traditional medications. Herbal products focused on conventional expertise have recently been widely popular
in developed and developing countries. Ayurveda is a medical science that deals with the treatment of
diseases using naturally occurring plant products. Ayurveda claims to have a large number of neuroprotective
herbs. This review discusses the pharmacological effects and therapeutic properties of In vivo, In vitro,
In silico and human clinical trials of (Bacopa monnieri) BM against AD.
Improving Telehealth Equity in Response to COVID-19 in California: ACTIVATE and Lighthouse
Authors: Lindeman David 
Published: June 2023

Background
In response to the significant stressors on health care delivery created by COVID-19, CITRIS Health and partner organizations developed 2 telehealth solutions through a rapid co-design process: Lighthouse and ACTIVATE. These programs were developed to support providers serving underserved and vulnerable populations who lack the tools and resources to support patients with chronic illness or who are isolated. These challenges were exacerbated by the COVID-19 pandemic, which increased the need for resources to support vulnerable patients who could not come into a clinic in person or were isolated and lacked access to services. ACTIVATE and Lighthouse apply 2 different telehealth strategies to reach vulnerable populations.

Objective
This paper presents lessons learned from the design, development, and implementation of 2 innovative telehealth programs developed to improve health care delivery, access to care, digital literacy, and patient outcomes: ACTIVATE and Lighthouse.

Methods
ACTIVATE is a comprehensive digital health pathway for community health centers that care for those who are medically underserved. ACTIVATE is an innovative, evidence-based, and sustainable telehealth program, designed to benefit vulnerable populations in rural and agricultural communities in the California Central Valley who experience significant health disparities. Lighthouse focuses on connecting older adults in congregate affordable housing, which are settings where residents are particularly vulnerable to isolation, the lack of health care resources, and limited to no access to the internet. Lighthouse provides digital literacy training as well as access to broadband internet with the goal of increasing communication, engagement, and access to health care.

Results
This presentation will discuss successful design and implementation strategies as well as organizational and policy barriers to program operations.

Conclusions
In addition to reviewing program and implementation outcomes, strategies for replication and sustainability will be discussed. Although developed in response to COVID-19, the ultimate success of Lighthouse and ACTIVATE is dependent upon its successful scaling beyond the pandemic.

Conflicts of Interest
None declared.
The Minimum Data Set for Rare Diseases: Systematic Review
Authors: Bernardi Filipe Andrade , Mello de Oliveira Bibiana , Bettiol Yamada Diego , Artifon Milena , Schmidt Amanda Maria , Machado Scheibe Victória , Alves Domingos , Félix Têmis Maria 
Published: June 2023

Background
The minimum data set (MDS) is a collection of data elements to be grouped using a standard approach to allow the use of data for clinical and research purposes. Health data are typically voluminous, complex, and sometimes too ambiguous to generate indicators that can provide knowledge and information on health. This complexity extends further to the rare disease (RD) domain. MDSs are essential for health surveillance as they help provide services and generate recommended population indicators. There is a bottleneck in international literature that reveals a global problem with data collection, recording, and structuring in RD.

Objective
This study aimed to identify and analyze the MDSs used for RD in health care networks worldwide and compare them with World Health Organization (WHO) guidelines.

Methods
The population, concept, and context methodology proposed by the Joanna Briggs Institute was used to define the research question of this systematic review. A total of 4 databases were reviewed, and all the processes were reported using the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) methodology. The data elements were analyzed, extracted, and organized into 10 categories according to WHO digital health guidelines. The quality assessment used the STROBE (Strengthening the Reporting of Observational Studies in Epidemiology) checklist.

Results
We included 20 studies in our review, 70% (n=14) of which focused on a specific health domain and 30% (n=6) of which referred to RD in general. WHO recommends that health systems and networks use standard terminology to exchange data, information, knowledge, and intelligence in health. However, there was a lack of terminological standardization of the concepts in MDSs. Moreover, the selected studies did not follow the same standard structure for classifying the data from their MDSs. All studies presented MDSs with limitations or restrictions because they covered only a specific RD, or their scope of application was restricted to a specific context or geographic region. Data science methods and clinical experience were used to design, structure, and recommend a fundamental global MDS for RD patient records in health care networks.

Conclusions
Our study highlights the difficulties in standardizing and categorizing findings from MDSs for RD because of the varying structures used in different studies. The fundamental RD MDS designed in this study comprehensively covers the data needs in the clinical and management sectors. These results can help public policy makers support other aspects of their policies. We highlight the potential of our results to help strategic decisions related to RD.

Trial Registration
PROSPERO CRD42021221593; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=221593

International Registered Report Identifier (IRRID)
RR2-10.1016/j.procs.2021.12.034