bluuebunny/crossref_metadata_2025_split huggingface dataset:
Modified percutaneous coronary intervention-derived risk models (PARIS and CREDO-Kyoto integer scoring systems) applied to Japanese transcatheter aortic valve replacement patients
Authors: Ohya Masanobu , Kohsaka Shun , Kumamaru Hiraku , Ikuta Akihiro , Nakano Jota , Shimamoto Takeshi , Watanabe Yusuke , Shimamura Kazuo , Maeda Koichi , Komiya Tatsuhiko , Fuku Yasushi , Kadota Kazushige 
Published: January 2023

ObjectivePostprocedural ischaemic and bleeding risks after transcatheter aortic valve replacement (TAVR) remain a major concern. Nevertheless, no reliable risk models incorporating both possibilities are currently available. We aimed to assess the accuracy of percutaneous coronary intervention (PCI)-derived models and the performance of a recalibrated model that included variables more applicable to TAVR.MethodsThis study included 26 869 patients who had been enrolled in a national registry. Ischaemic events were defined as myocardial infarction, stroke, transient ischaemic attack or peripheral embolism at 1 year. Bleeding events were defined as any bleeding based on the Valve Academic Research Consortium-2 consensus document at 1 year. Patterns of Non-adherence to Anti-Platelet Regimen in Stented Patients (PARIS) and Coronary Revascularisation Demonstrating Outcome Study in Kyoto (CREDO-Kyoto) integer scoring systems were tested. The models were recalibrated by applying new variables using the Fine and Gray method.ResultsThe 1-year cumulative incidences for ischaemic and bleeding events were 2.7% and 3.1%. Patients with high PARIS and CREDO-Kyoto risk scores had higher incidences of both ischaemic (3.3% vs 2.4% vs 2.4%, p<0.001 and 2.8% vs 2.0% vs 0.8%, p<0.001) and bleeding events (3.3% vs 2.5% vs 0.8%, p<0.001 and 3.7% vs 3.0% vs 2.4%, p<0.001) when compared with intermediate and low-risk patients. The receiver operating characteristic area under the curves for these models were 0.53, 0.58, 0.56 and 0.55, respectively. After the models were recalibrated to incorporate variables more applicable to TAVR, the performance of ischaemic and bleeding models modestly improved (0.58 and 0.61, respectively).ConclusionsThe PCI-derived models demonstrated modest accuracy but was inadequate for risk stratification of TAVR patients at 1-year follow-up.Trial registration number3395.
W boson mass in minimal Dirac gaugino scenarios
Authors: Benakli Karim , Goodsell Mark , Ke Wenqi , Slavich Pietro 
Published: January 2023

AbstractWe investigate the conditions for alignment in Dirac Gaugino models with minimal matter content. This leads to several scenarios, including an aligned Dirac Gaugino NMSSM that allows a light singlet scalar. We then investigate the compatibility of minimal Dirac Gaugino models with an enhanced W boson mass, using a new precise computation of the quantum corrections included in the code SARAH 4.15.0.
Three-dimensional Newtonian gravity with cosmological constant and torsion
Authors: Concha Patrick , Rodríguez Evelyn , Rubio Gustavo , Yañez Paola 
Published: January 2023

AbstractIn this paper we present an alternative cosmological extension of the three-dimensional extended Newtonian Chern–Simons gravity by switching on the torsion. The theory is obtained as a non-relativistic limit of an enhancement and U(1)-enlargement of the so-called teleparallel algebra and can be seen as the teleparallel analogue of the Newtonian gravity theory. The infinite-dimensional extension of our result is also explored through the Lie algebra expansion method. An infinite-dimensional torsional Galilean gravity model is presented which in the vanishing cosmological constant limit reproduces the infinite-dimensional extension of the Galilean gravity theory.
Efficiency of combined MA-XRF and CXRF to give nondestructive insights about changes of a historical painting
Authors: Tapia José , Eveno Myriam , Calligaro Thomas , Pichon Laurent , Laval Eric , Ravaud Elisabeth , Reiche Ina 
Published: January 2023

AbstractHistorical paintings with important iconographical changes represent an analytical challenge. Considering the case study of a fifteenth-century French painting studied during its restoration, the efficiency of a combined noninvasive approach of two-dimensional scanning macro-X-ray fluorescence imaging (MA-XRF) and a laboratory-based depth-resolved confocal micro-X-ray fluorescence (CXRF) is discussed. Large chemical maps of several elements were obtained by MA-XRF, enabling the identification of zones of interest representing changes in the painting composition. In these areas, depth profiles were measured with CXRF, allowing to evidence overlaying paint layers. The advantages of this technique are that it can give direct information on the stratigraphy of paint layers in a nondestructive way and can reduce the sampling needed, as well as increase the locations analyzed (in our study twenty-two depth-resolved scans). These results complement information obtained by scanning electron microscopy coupled with an energy-dispersive X-ray analyzing system (SEM–EDX) on three cross-sectional samples taken in the areas of interest. Additionally, the three cross sections of the painting were studied by CXRF lateral scans (y) in order to evaluate the efficiency of the CXRF analyses against SEM–EDX. The study shows the benefits of the combination of MA-XRF and CXRF for analyzing painting compositions, as such a high number of cross sections would have been impossible to sample. From an art-historical and conservation perspective, this combined study provides an understanding of the original painting’s paint sequence and its later retouches, helping to make informed conservation treatment decisions.
Graphic Abstract
Myeloid Maturity: ATRA to Enhance Anti–PD-1?
Authors: Olson Daniel J. , Luke Jason J. 
Published: January 2023

SummaryMyeloid-derived suppressor cells (MDSC) are associated with resistance to anti-PD-1 therapies. All-trans retinoic acid (ATRA) may induce maturation of MDSCs and alter their immunosuppressive effects. Adding ATRA to pembrolizumab may target this resistance mechanism to enhance the overall impact of anti-PD-1–based immunotherapy.See related article by Tobin et al., p. 1209
Structures of Cancer Antigen Mesothelin and Its Complexes with Therapeutic Antibodies
Authors: Zhan Jingyu , Lin Dong , Watson Nathan , Esser Lothar , Tang Wai Kwan , Zhang Alex , Liu Xiufen , Hassan Raffit , Gleinich Anne , Shajahan Asif , Azadi Parastoo , Pastan Ira , Xia Di 
Published: January 2023

The tumor-associated antigen mesothelin is expressed at high levels on the cell surface of many human cancers, while its expression in normal tissues is limited. The binding of mesothelin to the tumor-associated cancer antigen 125 (CA-125) can lead to heterotypic cell adhesion and tumor metastasis within the pleural and peritoneal cavities. Immunotherapeutic strategies targeting mesothelin are being intensively investigated. Here, we report the crystal structures of mesothelin that reveal a compact, right-handed solenoid consisting of 24 short helices and connecting loops. These helices form a nine-layered spiral coil that resembles ARM/HEAT family proteins. Glycan attachments have been identified in the structure for all three predicted N-glycosylation sites and confirmed with samples from cell culture and patient ascites. The structures of full-length mesothelin and its complex with the Fab of MORAb-009 reveal the interaction of the antibody with the complete epitope, which has not been reported previously. The N-terminal half of mesothelin is conformationally rigid, suitable for eliciting specific antibodies, whereas its C-terminal portion is more flexible. The structure of the C-terminal shedding-resistant fragment of mesothelin complexed with a mAb 15B6 displays an extended linear epitope and helps explain the protection afforded by the antibody for the shedding sites.Significance:The structures of full-length mesothelin and its complexes with antibodies reported here are the first to be determined experimentally, providing atomic models for structural organization of this protein and its interactions with antibodies. It offers insights into the function of mesothelin and guidance for further development of therapeutic antibodies.
High-amplitude network co-fluctuations linked to variation in hormone concentrations over the menstrual cycle
Authors: Greenwell Sarah , Faskowitz Joshua , Pritschet Laura , Santander Tyler , Jacobs Emily G. , Betzel Richard F. 
Published: January 2023

Abstract
Many studies have shown that the human endocrine system modulates brain function, reporting associations between fluctuations in hormone concentrations and brain connectivity. However, how hormonal fluctuations impact fast changes in brain network organization over short timescales remains unknown. Here, we leverage a recently proposed framework for modeling co-fluctuations between the activity of pairs of brain regions at a framewise timescale. In previous studies we showed that time points corresponding to high-amplitude co-fluctuations disproportionately contributed to the time-averaged functional connectivity pattern and that these co-fluctuation patterns could be clustered into a low-dimensional set of recurring “states.” Here, we assessed the relationship between these network states and quotidian variation in hormone concentrations. Specifically, we were interested in whether the frequency with which network states occurred was related to hormone concentration. We addressed this question using a dense-sampling dataset (N = 1 brain). In this dataset, a single individual was sampled over the course of two endocrine states: a natural menstrual cycle and while the subject underwent selective progesterone suppression via oral hormonal contraceptives. During each cycle, the subject underwent 30 daily resting-state fMRI scans and blood draws. Our analysis of the imaging data revealed two repeating network states. We found that the frequency with which state 1 occurred in scan sessions was significantly correlated with follicle-stimulating and luteinizing hormone concentrations. We also constructed representative networks for each scan session using only “event frames”—those time points when an event was determined to have occurred. We found that the weights of specific subsets of functional connections were robustly correlated with fluctuations in the concentration of not only luteinizing and follicle-stimulating hormones, but also progesterone and estradiol.
Convective-Scale Assimilation of Cloud Cover from Photographs Using a Machine Learning Forward Operator
Authors: Reinhardt Maria , Schoger Sybille Y. , Kurzrock Frederik , Potthast Roland 
Published: January 2023

Abstract
This paper presents an innovational way of assimilating observations of clouds into the icosahedral nonhydrostatic weather forecasting model for regional scale (ICON-D2), which is operated by the German Weather Service (Deutscher Wetterdienst) (DWD). A convolutional neural network (CNN) is trained to detect clouds in camera photographs. The network’s output is a grayscale picture, in which each pixel has a value between 0 and 1, describing the probability of the pixel belonging to a cloud (1) or not (0). By averaging over a certain box of the picture a value for the cloud cover of that region is obtained. A forward operator is built to map an ICON model state into the observation space. A three-dimensional grid in the space of the camera’s perspective is constructed and the ICON model variable cloud cover (CLC) is interpolated onto that grid. The maximum CLC along the rays that fabricate the camera grid, is taken as a model equivalent for each pixel. After superobbing, monitoring experiments have been conducted to compare the observations and model equivalents over a longer time period, yielding promising results. Further we show the performance of a single assimilation step as well as a longer assimilation experiment over a time period of 6 days, which also yields good results. These findings are proof of concept and further research has to be invested before these new innovational observations can be assimilated operationally in any numerical weather prediction (NWP) model.
Projected Impacts of Antarctic Meltwater Anomalies over the Twenty-First Century
Authors: Purich Ariaan , England Matthew H. 
Published: January 2023

Abstract
Antarctic margin and Southern Ocean surface freshening has been observed in recent decades and is projected to continue over the twenty-first century. Surface freshening due to precipitation and sea ice changes is represented in coupled climate models; however, Antarctic ice sheet/shelf meltwater contributions are not. Because Antarctic melting is projected to accelerate over the twenty-first century, this constitutes a fundamental shortcoming in present-day projections of high-latitude climate. Southern Ocean surface freshening has been shown to cause surface cooling by reducing both ocean convection and the entrainment of warm subsurface waters to the surface. Over the twenty-first century, Antarctic meltwater is expected to alter the pattern of projected surface warming as well as having other climatic effects. However, there remains considerable uncertainty in projected Antarctic meltwater amounts, and previous findings could be model dependent. Here, we use the ACCESS-ESM1.5 coupled model to investigate global climate responses to low and high Antarctic meltwater additions over the twenty-first century under a high-emissions climate scenario. Our high-meltwater simulations produce anomalous surface cooling, increased Antarctic sea ice, subsurface ocean warming, and hemispheric differences in precipitation. Our low-meltwater simulations suggest that the magnitude of surface temperature and Antarctic sea ice responses is strongly dependent on the applied meltwater amount. Taken together, these findings highlight the importance of constraining projections of Antarctic ice sheet/shelf melt to better project global surface climate changes over the twenty-first century.

Significance Statement
Antarctic ice sheets and shelves are melting, adding meltwater to the Southern Ocean and changing the ocean circulation. Antarctic meltwater stratifies the upper ocean, resulting in cooling of the surface Southern Ocean but warming at depth that could accelerate ice shelf melting. Coupled climate models used to project twenty-first-century climate do not represent ice sheets or shelves, neglecting important climate impacts. Here we conduct meltwater simulations with a coupled climate model and find that the magnitude of climate responses is strongly dependent on the applied meltwater amount. This highlights 1) the importance of constraining Antarctic meltwater projections to better project global climate over the twenty-first century and 2) that it is important that Antarctic meltwater be represented in future-generation coupled climate models.
Do Simulated Augmented Reality Overlays Influence Street-Crossing Decisions for Non-Mobility-Impaired Older and Younger Adult Pedestrians?
Authors: Malik Jeehan , Kim Nam-Yoon , Parr Morgan D. N. , Kearney Joseph K. , Plumert Jodie M. , Rector Kyle 
Published: January 2023

Objective This study used a virtual environment to examine how older and younger pedestrians responded to simulated augmented reality (AR) overlays that indicated the crossability of gaps in a continuous stream of traffic. Background Older adults represent a vulnerable group of pedestrians. AR has the potential to make the task of street-crossing safer and easier for older adults. Method We used an immersive virtual environment to conduct a study with age group and condition as between-subjects factors. In the control condition, older and younger participants crossed a continuous stream of traffic without simulated AR overlays. In the AR condition, older and younger participants crossed with simulated AR overlays signaling whether gaps between vehicles were safe or unsafe to cross. Participants were subsequently interviewed about their experience. Results We found that participants were more selective in their crossing decisions and took safer gaps in the AR condition as compared to the control condition. Older adult participants also reported reduced mental and physical demand in the AR condition compared to the control condition. Conclusion AR overlays that display the crossability of gaps between vehicles have the potential to make street-crossing safer and easier for older adults. Additional research is needed in more complex real-world scenarios to further examine how AR overlays impact pedestrian behavior. Application With rapid advances in autonomous vehicle and vehicle-to-pedestrian communication technologies, it is critical to study how pedestrians can be better supported. Our research provides key insights for ways to improve pedestrian safety applications using emerging technologies like AR.
Human papillomavirus vaccination coverage among sexually active young adults aged 18 to 26 at a sexually transmitted infections clinic
Authors: Tao Jun , Kapadia Jhanavi , Fenn Natalie , Almonte Alexi A , Toma Emily , Murphy Matthew , Nunn Amy , Su L Joseph , Chan Philip A 
Published: January 2023

Background Human papillomavirus (HPV) vaccination is the most effective biomedical intervention for HPV infections. HPV vaccination rate among sexually active young adults is largely unknown. Methods Patients aged 18–26 years, who attended the Rhode Island Sexually Transmitted Infections Clinic between 2013–2018, were included in the study. We extracted demographics, behavioral characteristics, and HPV vaccination status from electronic medical records. Exploratory logistic regressions were conducted to identify factors associated with vaccination status. Results Among 2729 eligible individuals, the median age was 23 years (interquartile range: 22–25). Only 8.1% of males and 24.8% of females received at least one dose of HPV vaccine. Females were 144% (crude odds ratio [cOR]: 2.44, 95% confidence interval [CI]: 2.03, 2.94) more likely to receive at least one dose of HPV vaccine than males. Being Black/African American (B/AA) or Hispanic/Latino (H/L) was associated with a 21% (cOR: 0.79, 95% CI: 0.62, 1.00) and 34% (cOR: 0.66, 95% CI: 0.53, 0.81) decrease in the odds of vaccination, respectively. Conclusions HPV vaccination rate was low among sexually active young adults. Gender and racial/ethnic disparities existed in HPV vaccination. Interventions are needed to promote HPV vaccination among sexually active young adults, especially B/AA and H/L communities.
Does the balloon-assisted maturation procedure offer comparable results for AVF created with a smaller vein?
Authors: Huang Hsuan-Chiao , Hsu Chiann-Yi , Kang Ming-Yuan 
Published: January 2023

Background: Traditionally, a venous diameter of less than 3 mm was not considered for creation of AVF. Some studies have reported smaller venous size could be used for operation. AVF created with a smaller vein may have a lower maturation rate. Currently, percutaneous angioplasty is also used to enhance the maturation of AVF. This study aimed to establish whether the BAM procedure could offer comparable results for AVF created with a smaller vein. Methods: From January 2016 to July 2021, 290 patients who received native AVF operation were enrolled in this study. All of the preoperative venous sizes were measured by Duplex ultrasonography under tourniquet enhancement. The study cohort was categorized into two groups based on the pre-operative venous diameter: smaller vein group (SVG, 2.5 < size < 3 mm, 53.1%) and normal vein group (NVG, size ⩾ 3 mm, 46.9%). Results: The mean age was 64 ± 12.9 years, and 58.6% of patients were male. Hypertension and DM were the most common comorbidities. Most patients underwent operation of radio-cephalic fistula (71.4%). The overall primary maturation rate was 79%. The primary maturation rate was significantly higher in the NVG (86% vs 72.7%, p = 0.009). However, after the BAM procedure, the secondary maturation rate was similar in both groups (94.1% vs 90.3%, p = 0.319). Conclusions: According to our study, the BAM procedure can significantly increase the maturation rate, and the secondary maturation rate was similar in both groups. Thus, more patients can be given the opportunity to undergo creation of an AVF for long-term hemodialysis.
A Statistical Investigation into the COVID-19 Outbreak Spread
Authors: Parvin Rehana 
Published: January 2023

Objective: Coronavirus-19 (COVID-19) outbreaks have been reported in a range of climates worldwide, including Bangladesh. There is less evidence of a link between the COVID-19 pandemic and climatic variables. This research article’s purpose is to examine the relationship between COVID-19 outbreaks and climatic factors in Dhaka, Bangladesh. Methods: The daily time series COVID-19 data used in this study span from May 1, 2020, to April 14, 2021, for the study area, Dhaka, Bangladesh. The Climatic factors included in this study were average temperature, particulate matter ([Formula: see text]), humidity, carbon emissions, and wind speed within the same timeframe and location. The strength and direction of the relationship between meteorological factors and COVID-19 positive cases are examined using the Spearman correlation. This study examines the asymmetric effect of climatic factors on the COVID-19 pandemic in Dhaka, Bangladesh, using the Nonlinear Autoregressive Distributed Lag (NARDL) model. Results: COVID-19 widespread has a substantial positive association with wind speed ( r = .781), temperature ( r = .599), and carbon emissions ( r = .309), whereas [Formula: see text] ( r = −.178) has a negative relationship at the 1% level of significance. Furthermore, with a 1% change in temperature, the incidence of COVID-19 increased by 1.23% in the short run and 1.53% in the long run, with the remaining variables remaining constant. Similarly, in the short-term, humidity was not significantly related to the COVID-19 pandemic. However, in the long term, it increased 1.13% because of a 1% change in humidity. The changes in PM2.5 level and wind speed are significantly associated with COVID-19 new cases after adjusting population density and the human development index.
Disinformation and weaponized communication: The spread of ideological hate about the Macedonian name in Greece
Authors: Karyotakis Minos-Athanasios 
Published: January 2023

The study examined through ideological discourse analysis (IDA) 38 widely spread disinformation-laced news stories (or “fake news”) regarding the Macedonian Name Dispute (MND) and the “Prespes Agreement” in the years 2018 and 2019. The paper explores the ideological narratives and constructions disseminated through the disinformation-laced news stories during these 2 years. Therefore, the study expands the relevant literature regarding democracy, disinformation, and hate campaigns by examining the ideological narratives and constructions disseminated through the disinformation-laced news stories during that two-years-period. The findings showed that those news stories were successfully weaponized and resulted in empowering identity characteristics and ideological narratives through the distancing method (us vs them), the alienation with elements of dramatization (e.g. territorial loss of the Greek Macedonia due to the “Prespes Agreement”), and the sense of victimization and dehumanization that demanded emergency actions to protect the ingroup (Greece) from the outgroup (North Macedonia and its Greek assistants).