bluuebunny/crossref_metadata_2025_split huggingface dataset:
EFFECTIVE SOLUTIONS FOR COMMON PROBLEMS OF ARTIFICIAL POTENTIAL FIELD BASED PATH PLANNING ALGORITHMS FOR MOBILE ROBOTS
Authors: AKARSU Muhammet Emre , ÇETİN Ömer 
Published: January 2023

Abstract
Autonomous Path Planning (APP) capability is one of the main factors determining the autonomous level of a mobile robot. Although different methods are used for APP in the literature, the path planning approach based on Artificial Potential Fields (APF) has a very common usage area with its modeling ease and computational performance. APF-based APP, which is a grid-based path planning approach, is usually performed by combining a repulsive and attractive component that models many basic motions with a certain equation and calculating the gradient of this potential field to obtain the vector field. In this study, the basic models used for APF-based APP are examined, and how they are realized and how the resultant potential field is produced are mentioned. Although APF-based APP approaches have advantages, they also have problems such as local minimum, obstacles positioned too close, oscillation, and targets positioned too close to obstacles. Within the scope of the study, these problems were defined one by one and the approaches suggested in the literature for the solution of these problems were mentioned in detail. As a result, it has been seen that to obtain an effective APF-based APP solution, it is necessary to generate a convolutional vector field, limit the fundamental potential fields with exponential functions, use virtual potential fields and perform models with harmonic functions.
Spiritual Dimension in Film
Authors: Faisal Ai Ahmad 
Published: January 2023

Eksistensi Gambar dalam film menurut Gilles Deleuze adalah kehidupan manusia dan perjalanannya menyatu dengan Tuhan. Ketika manusia menyaksikan film pikirannya tertuju pada objek gambar- gambar yang bergerak sehingga dirinya ikut bersatu dengan realitas yang ada pada film. Otak manusia seperti layar film yang mampu menyingkap realitas dan pikiran manusia mulai tenggelam dan menyatu dengan alam semesta, karena otak manusia mengeluarkan elektron yang bermuatan negatif dari atom-atom kemudian elektron tersebut tertarik dan mengikuti gerakan dari gambar-gambar yang ada di film yang bermuatan positif sehingga munculnya energi listrik dan gelombang, frekuensi cahaya yang mengakibatkan manusia mengalami pencapaian spiritual. Tujuan dari artikel ini adalah untuk membuktikan bahwa segala sesuatu di dunia ini mengalami perubahan dan ketidakpastian sedangkan eksistensi manusia di di dunia ini adalah tidak ada. Di dunia ini yang ada hanya energi dan hukum perubahan alam semesta. Hal itu dikarenakan manusia sudah menyatu dengan Tuhan dan alam semesta. Manusia yang sudah mengalami pencerahan memanifestasikan dirinya dengan mengimajinasikan semua hal tentang kehidupan dunia fisiknya. Dengan demikian, kehidupan di dunia adalah sebuah alam imajinasi atau pikiran saja.
Penelitian ini menggunakan pendekatan deskriptif analitis dan metode deskriptif kuantitatif yang bersifat saintifik dengan mengintegralkan aspek kesenian, filsafat, mistisisme, spiritualisme, fisika klasik, fisika kuantum, mekanika kuantum dan kimia kuantum. Kesimpulan dari tulisan ini adalah manusia mengalami pencerahan dan mengalami perubahan forma atau bentuk dianalisa secara spiritual dan saintifik serta dapat memanifestasikan dan mengaktualisasikan aspek spiritualitasnya dalam bentuk materialisme di berbagai bidang disiplin ilmu seperti politik, ekonomi, geopolitik, kesenian, teknologi, sains, psikologi, agama dan budaya. Dengan demikian, manusia yang sudah tercerahkan dan mengalir energi alam semesta di dalam dirinya menjadi sebuah mesin atau alat pembangkit listrik bertenaga energi spiritual yang termanifestasikan dan terealisasi di dunia fisik.
Economic Empowerment, HIV Risk Behavior, and Mental Health Among School-Going Adolescent Girls in Uganda: Longitudinal Cluster-Randomized Controlled Trial, 2017‒2022
Authors: Ssewamala Fred M. , Brathwaite Rachel , Neilands Torsten B. 
Published: January 2023

Objectives. To investigate the long-term (12- and 24-month) impact of an economic empowerment intervention on HIV risk behaviors and mental health among school-going adolescent girls in Uganda. Methods. A total of 1260 girls aged 14 to 17 years were randomized at the school level to (1) standard health and sex education (controls; n = 408 students; n = 16 schools), (2) 1-to-1 matched savings youth development account (YDA; n = 471 students; n = 16 schools), or (3) combination intervention (YDA and multiple family group [YDA+MFG]; n = 15 schools; n = 381 students). Mixed-effects models were fitted. Results. YDA and YDA+MFG girls had significantly lower depressive symptoms and better self-concept than controls at 24 months. Only YDA+MFG girls had significantly lower hopelessness levels than controls. There were no significant study group differences at 12 and 24 months for sexual risk-taking behavior and attitudes. There was no significant difference between YDA and YDA+MFG groups for all outcomes. Conclusions. Providing YDA and MFG can positively improve adolescent girls’ mental health, but our analyses showed no significant differences across groups on sexual risk-taking behaviors. Future studies may consider replicating these interventions and analyses in older populations, including those transitioning into young adults. Trial Registration. ClinicalTrials.gov Identifier: NCT03307226. (Am J Public Health. 2023;113(3):306–315. https://doi.org/10.2105/10.2105/AJPH.2022.307169 )
Nanoparticle-Surfactant Stabilized Strong Foam for Enhanced Oil Recovery in High-Salinity Fractured Carbonate Reservoirs
Authors: Wang Xuezhen , Zhou Jimin , Pang Jieqiong , Mohanty Kishore K. 
Published: January 2023

Summary
Foam flooding can minimize bypassing in gasfloods in fractured reservoirs. Finding a foam formulation effective in high-salinity brine is challenging, especially with divalent cations, e.g., American Petroleum Institute (API) brine (8% NaCl with 2% CaCl2). When formulating with nanoparticles, the colloidal dispersion stability is difficult due to the dramatic reduction in zeta potential and the Debye length at high salinity. The aim of this work was to develop a strong foam in API brine at the ambient temperature, using a nonionic surfactant and ethyl cellulose nanoparticles (ECNP), for gasflooding in fractured carbonate reservoirs. ECNPs was synthesized and dispersed in API brine using a nonionic surfactant (also denoted as SF). SF and SF/ECNP foams were generated, and their stability was studied at atmospheric pressure and 950 psi. Foam mobility was measured in a sandpack at high pressure. Foam flood experiments were conducted in oil-saturated fractured carbonate cores. The nonionic surfactant proved to be a good dispersion agent for ECNP in API brine. The SF/ECNP mixture stabilized foam in API brine, even in the presence of oil. Injecting a partially miscible gas (below its minimum miscibility pressure) as an SF foam into a fractured core more than doubles the oil recovery over injection of the gas alone. The injection of the strong foam (SF/ECNP) further improves the oil recovery over that of the SF foam, indicating the synergy between ECNP and surfactant. ECNP accumulates in the foam lamella and induces larger pressure gradients in the fracture to divert more gas into the matrix for oil displacement.
Trans-Pacific Multicenter Collaborative Study of Minimally Invasive Proximal Versus Total Gastrectomy for Proximal Gastric and Gastroesophageal Junction Cancers
Authors: Ikoma Naruhiko , Grotz Travis , Kawakubo Hirofumi , Kim Hyoung-Il , Matsuda Satoru , Hirata Yuki , Nakao Atsushi , Williams Lori , Wang Xin , Mendoza Tito , Wang Xuemei , Badgwell Brian , Mansfield Paul , Hyung Woo-Jin , Kitagawa Yuko 
Published: January 2023

Abstract
Background: The current standard operation for proximal gastric and gastroesophageal junction (P/GEJ) cancers with limited esophageal extension is total gastrectomy (TG). TG is associated with impaired appetite and weight loss, which is caused by a decreased level of ghrelin and anemia due to intrinsic factor loss and vitamin B12 malabsorption. Theoretically, proximal gastrectomy (PG) can mitigate these problems by preserving gastric function. However, PG with direct esophagogastric reconstruction is associated with severe postoperative reflux, delayed gastric emptying, and poor quality of life (QoL). Minimally invasive PG (MIPG) with antireflux techniques has been increasingly performed by experts but is technically demanding owing to its complexity. Moreover, the actual advantages of MIPG over minimally invasive TG (MITG) with regards to postoperative QoL are unknown. Our overall objective of this study is to determine the short-term QoL benefits of MIPG. Our central hypotheses are that MIPG is safe and that patients have improved appetite after MIPG with effective antireflux techniques, which leads to an overall QoL improvement when compared with MITG.
Methods: Enrollment of a total of 60 patients in this prospective survey-collection study is expected. Procedures (MITG versus MIPG, antireflux techniques for MIPG [double-tract reconstruction versus the double-flap technique]) will be chosen based on surgeon and/or patient preference. Randomization is not considered feasible because patients often have strong preferences regarding MITG and MIPG. The primary outcome is appetite level (reported on a 0-10 scale) at 3 months after surgery. With an expected 30 patients per cohort (MITG versus MIPG), this study will have 80% power to detect a one-point difference in appetite level. Patient-reported outcomes will be longitudinally collected (including questions about appetite and reflux), and specific QoL items, body weight, body mass index and ghrelin, albumin, and hemoglobin levels will be compared.
Discussion: Surgeons from the US, Japan, and South Korea formed this collaboration with the agreement that the surgical approach to P/GEJ cancers is an internationally important but controversial topic that requires immediate action. At the completion of the proposed research, our expected outcome is the establishment of the benefit and safety of MIPG.
Trial Registration Number: This trial was registered with Clinical Trials Reporting Program Registration under the registration number NCI-2022-00267 on January 11, 2022, as well as with ClinicalTrials.gov under the registration number NCT05205343 on January 11, 2022.
Quadruplet expanded DNA (QED) genetic code for eukaryotic cells**
Authors: Singh Rama Shankar 
Published: January 2023

Abstract
Genetic code translates eukaryotic cell genes into proteins for maintaining a homeostatic state. However, gene variants, transcription, and splicing errors yield dysfunctional proteins causing monogenic rare, multigenic cancers and neuro-degenerate diseases. The triplet genetic code encodes a protein but lacks gene, transcription, and splicing controls. Furthermore, alternative orthogonally expanded genetic codes failed to synthesize proteins using canonical amino acids. The QED codon was developed to overcome these limitations. While verifying the triplet genetic code, 1968 Medicine Nobel laureate H.G. Khorana observed that self-complementarity forming adjacent bases, Poly r-AU, did not promote polypeptide formation, a noncoding trait. The QED noncoding codons have similar traits. Here, the QED codon model is assumed to comprise all four DNA bases (T, C, A, and G); the code is position-independent and symmetric. The self-complementarity forming adjacent bases (AU) and (C G) with any two NN (N any T, C, A, and G) bases are noncoding. Under these QED assumptions, 256 quadruplets fall into two groups: 20 independent protein-encoding codons and 35 independent noncoding codons applicable to regulating and controlling synthesis, transcription, and splicing processes. Steps to correct dysfunctional proteins are described, anticipating strategies for developing cures for monogenic rare, multigenic cancers and neurodegenerative diseases.

**Patent Pending
Clinical Presentation and Molecular Diagnosis of Monkeypox Virus and Varicella Zoster Virus Co-infection in an Adult Immunocompetent Filipino: A Case Report
Authors: Balingit April Keith , Grande Phoebe Grace , Nicolasora Amalea Dulcene , Polotan Francisco Gerardo , Pantoni Roslind Anne , Chu Maria Yna Joyce , Rivera Nicole , Oblepias Marie Socouer , Garcia Jemelyn 
Published: January 2023

Abstract
BACKGROUND

Following the detection of the first laboratory-confirmed Monkeypox (MPXV) infection in the Philippines, guidelines on Monkeypox diagnosis, treatment, and prevention have been strengthened to further help healthcare providers in differentiating it properly from other diseases with similar clinical presentation, one of which is Varicella zoster (VZV) infection. Interestingly, co-infection with Monkeypox and Varicella has been previously reported in Monkeypox endemic countries. We then report the first travel-related case of MPXV-VZV co-infection in the Philippines, a country that is endemic for Varicella but non-endemic for Monkeypox.

CASE PRESENTATION

A 29-year-old Filipino, female, with a travel history to Switzerland and with no prior history of VZV infection consulted due to rashes. She presented with multiple papular, pustular, and vesicular skin lesions, some with umbilication and with irregular borders, on the face, neck, trunk, inguinal area, upper extremities, and right leg. She also had bilateral submandibular and post-auricular lymphadenopathies. Tzanck smear exhibited viral cytopathic effects. She was confirmed to have Monkeypox infection from Clade II and Varicella infection via quantitative real-time polymerase chain reaction (qPCR) tests. Shotgun metagenomic sequencing (mNGS) successfully recovered sequences from the Varicella zoster virus which corroborated with the high viral load detected using qPCR. In contrast, shotgun mNGS showed too few reads mapped to the Monkeypox virus reference sequence. Systemic and topical acyclovir was given to the patient. She was discharged and continued home isolation for 30 days from the rash onset.

CONCLUSION

Strategies have been formed by the country’s healthcare facilities to properly identify monkeypox infection. However, Monkeypox co-infection with other viral diseases presented a challenge in the proper diagnosis of our patient. This prompted a high index of suspicion and the usage of suitable diagnostic tests. The qPCR tests confirmed the presence of both Monkeypox and Varicella zoster virus infections in the patient. Shotgun metagenomic sequencing (mNGS) successfully recovered sequences from the Varicella zoster virus, while there were too few reads mapped to the Monkeypox virus reference sequence. With proper clinical evaluation and utilization of appropriate diagnostic tests, we were able to diagnose the first Filipino patient with Monkeypox and Varicella zoster virus co-infection.
Preoperative Ultrasound-based Protocol for Optimisation of Fluid Therapy to Prevent Early Intraoperative Hypotension: A Randomised Controlled Study
Authors: Szabó Marcell , Pleck András , Soós Sándor Árpád , Keczer Bánk , Varga Balázs , Széll János 
Published: January 2023

Abstract
Background: Intraoperative hypotension is a risk factor for postoperative complications. Preoperative dehydration is a major contributor, although it is difficult to estimate its severity. Point-of-care ultrasound offers several potential methods, including measurements of the inferior vena cava. The addition of lung ultrasound may offer a safety limit.
We aimed to evaluate whether the implication of an ultrasound-based preoperative fluid therapy protocol can decrease the incidence of early intraoperative hypotension.
Methods: Randomised controlled study in a tertiary university department involving elective surgical patients of ASA 2-3 class, scheduled for elective major abdominal surgery under general anaesthesia with intubation. We randomized 40–40 patients; 38–38 were available for analysis. Conventional fluid therapy was ordered on routine preoperative visits. Ultrasound-based protocol evaluated the collapsibility index of inferior vena cava and lung ultrasound profiles. Scans were performed twice: 2 h and 30 min before surgery. A high collapsibility index (≥40%) indicated a standardised fluid bolus, while the anterior B-profile of the lung ultrasound contraindicated further fluid. The primary outcome was the incidence of postinduction and early intraoperative (0–10 minutes) hypotension (MAP<65 mmHg and/or ≥30% of decrease from baseline). Secondary endpoints were postoperative lactate level, urine output and lung ultrasound score at 24 h.
Results: The absolute criterion of postinduction hypotension was fulfilled in 12 patients in the conventional group (31.6%) and 3 in the ultrasound-based group (7.9%) (p=0.0246). Based on composite criteria, we observed 17 (44.7%) and 7 (18.4%) cases, respectively (p=0.0136). The incidence of early intraoperative hypotension was also lower: HR for absolute hypotension was 2.10 (95%CI 1.00–4.42) in the conventional group (p=0.0387). Secondary outcome measures were similar in the study groups.
Conclusion: We implemented a safe and effective point-of-care ultrasound-based preoperative fluid replacement protocol into perioperative care.
Trial registration: The study was registered to Clinicaltrials.gov on 10/12/2021, registration number: NCT05171608 (registered prospectively on 10/12/2021)
Carbon emission forecasting and decoupling based on a combined extreme learning machine model with particle swarm optimization algorithm: the example of Chongqing, China in the “14th Five-Year Plan” period
Authors: Liu Bo , Chang Haodong , Li Yan , Zhao Yipeng 
Published: January 2023

Abstract
Since the carbon peaking and carbon neutrality goals was included into the ecological civilization construction system, every province and city in China have been actively released their local the carbon peaking and carbon neutrality plans for the “14th Five-Year Plan”. To address the problems of slow updating of carbon emission data and low accuracy of traditional forecasting models, this paper used data from Chongqing, China, to conduct a study on the subject. this paper measured carbon emissions according to the IPCC method，and assessing the development process of resources and environment by means of decoupling analysis. The important factors influencing carbon emissions are selected by the grey correlation method, and the scenario forecast indicators are constructed according to the relevant policy documents of Chongqing, and the important factors and the consumption of coal, oil and natural gas are taken as the inputs of a single forecast model. The following conclusions were obtained: by comparison, the PSO-ELM model is the best model for predicting carbon emissions in Chongqing. The following conclusions were obtained: the combined PSO-ELM prediction model has lower prediction error and higher accuracy, and is more suitable for carbon emission research. The prediction results show that the carbon emissions in Chongqing during the “14th Five-Year Plan” still maintain upward trend, but the growth rate has slowed down compared with 1998-2018, and the carbon emissions tend to stabilize. Overall, there is a weak decoupling between carbon emissions and GDP in Chongqing from 1998 to 2025.
A Systematic Review of Intellectual and Developmental Disability Curriculum in International Pre-Graduate Health Professional Education
Authors: Vi Lisa , Jiwa Muhammad Irfan , Lunsky Yona , Thakur Anupam 
Published: January 2023

Abstract
Background
Despite the increasing global population of individuals with intellectual and developmental disabilities (IDD), this population remains especially vulnerable to health disparities through several factors such as a lack of access to sufficient medical care and poor determinants of health. To add, numerous studies have shown that healthcare professionals are still insufficiently prepared to support this population of patients. This review synthesizes the literature on current pre-graduate IDD training programs across healthcare professions with the goal of informing the creation of evidence-based curricula.
Methods
Four major databases were searched for current pre-graduate IDD training interventions for healthcare professionals. The Preferred Reporting Items for Systematic Reviews and Meta-Analysis flow diagram and the Best Evidence Medical Educations systematic review guide were used to frame our collection and analysis.
Results
Of the 6236 studies screened, 24 studies were identified, with most studies involving medical students (50%). Of note, 38% of studies were interprofessional. Most interventions utilized multiple pedagogical methods with a majority including clinical experiences (83%) followed by theoretical teaching (50%). Kirkpatrick outcomes showed 13% were level 0, 9% were level 1, 17% were level 2, 33% were level 2B, 25% were level 3, 4% were level 4A, and none were level 4B.
Conclusions
There is a paucity of formally evaluated studies in pre-graduate health professional IDD education. As well, there are a lack of longitudinal learning opportunities and integration into formal curriculum. Strengths identified were the use of multimodal approaches to teaching, including interprofessional approaches to optimize team competencies.
Highly Conformable Chip-in-Foil Implants for Neural Applications
Authors: Stieglitz Thomas , Gueli Calogero , Martens Julien , Eickenscheidt Max , Floto Niklas , Sporer Markus , Ortmanns Maurits 
Published: January 2023

Abstract
Demands on neural interfaces in terms of functionality, high spatial resolution, and longevity have recently increased. These requirements can be met with sophisticated silicon-based integrated circuits. Embedding miniaturized dice in flexible polymer substrates significantly improves the adaptation to the mechanical environment in the body and thus the systems’ structural biocompatibility as well as the ability to cover larger areas of the brain. This work addresses main challenges in developing a hybrid chip-in-foil neural implant. Assessments were related to: first, the mechanical compliance to the recipient tissue that allows a long-term application, and second, the suitable design that allows the implant’s scaling and modular adaptation of chip arrangement. Finite element model studies were performed to identify design rules regarding die geometry, interconnect routing, and positions for contact pads on dice. Providing edge fillets in the die base shape was an effective measure to improve die-substrate integrity and increase the area available for contact pads. Furthermore, the routing of interconnects in the immediate vicinity of die corners should be avoided, as the substrate in these areas is prone to mechanical stress concentration. Contact pads on dice should be placed with a clearance from the die rim to avoid delamination when the implant is conformed to a curvilinear body. A microfabrication process was developed to transfer, align and electrically interconnect multiple dice into conformable polyimide-based substrates. The process enabled arbitrary die shape and size and independent target positions on the conformable substrate from the die position on the fabrication wafer.