bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENGARUH EARNING OPACITY, OWNERSHIP STRUCTURE, DAN CAPITAL INTENCITY TERHADAP TAX AVOIDANCE
Authors: Ikhsan Muhammad , Febriyanto Fery Citra 
Published: July 2023

ABSTRAK
Salah satu sumber pendapatan negara yang memiliki kontribusi terbesar dari seluruh pendapatan negara Indonesia adalah pajak. Penelitian ini dilakukan bertujuan untuk mengetahui faktor-faktor apa saja yang dapat mempengaruhi Tax Avoidance di Indonesia dengan variabel independen yaitu Earning Opacity, Ownership Structure, dan Capital Intencity. Jenis penelitian yang digunakan adalah penelitian kuantitatif. Jumlah sampel yang digunakan dalam penelitian ini sebanyak 45 data dari 9 Laporan Keuangan perusahaan Kesehatan Sub Sektor Farmasi yang terdaftar pada Bursa Efek Indonesia (BEI) tahun 2017 - 2021 yang diperoleh dengan menggunakan purposive sampling berdasarkan kriteria yang telah ditentukan. Teknik analisis data yang digunakan adalah statistik deskriptif dan analisis regresi data panel dengan menggunakan software Eviews 9. Berdasarkan hasil penelitian menunjukan bahwa Earning Opacity, Ownership Structure, dan Capital Intencity secara simultan berpengaruh signifikan terhadap Tax Avoidance. Secara parsial Ownership Structure dan Capital Intencity tidak berpengaruh signifikan terhadap Tax Avoidance, sedangkan Earning Opacity berpengaruh terhadap Tax Avoidance. Koefisien determinasi mempunyai nilai sebesar 87,4828%, hal ini menunjukkan tingkat pengaruh yang diberikan variabel independen terhadap variabel dependen kuat dan sisanya 12,5172% dapat dijelaskan oleh variabel independen lain yang tidak terdapat dalam penelitian ini.
Kata Kunci: Earning Opacity, Ownership Structure, Capital Intencity, Tax Avoidance
Inheriting the sins of their fathers: boar life experiences can shape the emotional responses of their offspring
Authors: Sabei Leandro , Parada Sarmiento Marisol , Bernardino Thiago , Çakmakçı Cihan , Farias Sharacely de Souza , Sato Denis , Zanella Márcia Inês Grapeggia , Poletto Rosangela , Zanella Adroaldo José 
Published: July 2023

IntroductionThe welfare of breeding boars is often overlooked, resulting in limited scientific data to foster discussion of the topic. We aimed to investigate the effect of different boar housing conditions on their offspring’s emotionality.MethodsEighteen boars were housed in three different conditions: crates (C; n = 6), pens (P; n = 6), or enriched pens (E; n = 6). Boars were distributed by semen quality (SQ; high, medium, or low). Three semen pools were used to inseminate 13 gilts housed in outdoor paddocks. At 25 days of age, 138 suckling piglets were subjected to open field (OF), novel object (NO), and elevated plus-maze (EPM) tests. Saliva was collected before and after the OF and NO tests to measure cortisol concentrations. At the end of the experiment, hair samples were collected for DNA paternity tests. Piglets were classified based on their behavioral responses using hierarchical cluster analysis of the principal components extracted from factor analysis of mixed data. The variables were reduced to seven principal components (dimensions, Dims), which explained 73% of the total variation, and were analyzed using linear mixed models. The models included each Dim as a dependent variable, paternal treatment and body weight (BW) as fixed effects, and paternal SQ as a random effect. Kruskal−Wallis and Wilcoxon rank-sum tests were used to compare the cortisol concentration ratios (before and after the OF and NO tests) between groups.ResultsThere was an effect of treatment on Dim 3 (EPM; activity/fear), with higher values in C piglets than E piglets (p = 0.047). Although C piglets had significantly higher values than P piglets in Dim 4 (EPM; anxiety; p = 0.029) and Dim 6 (NO; inactivity far from the object/exploration; p &lt; 0.0001), the effect of the paternal treatment × BW interaction was significant in both dimensions (p &lt; 0.05). The cortisol ratio in E piglets was greater than that in P and C piglets (p &lt; 0.05).Discussion and conclusionOur findings indicate that boar breeding environments affect the stress response and emotionality (anxiety, fear, and exploration) of their offspring.
Spectrum of ascending aortic aneurysms at a peri-urban tertiary hospital: an echocardiography-based study
Authors: Meel Ruchika , Hasenkam Michael , Goncalves Ricardo , Blair Kelly , Mogaladi Shungu 
Published: July 2023

IntroductionThoracic ascending aortic (TAA) aneurysms are an important cause of disability and death and require early detection for effective management. Currently, there is a paucity of data from Africa pertaining to TAA aneurysms. This study describes the spectrum of TAA aneurysms at a peri-urban tertiary hospital.MethodsA descriptive retrospective study based on clinical and echocardiographic imaging data of patients with TAA aneurysms from October 2017–October 2022. Advanced strain imaging was performed to measure left ventricular (LV) basal, apical, and global longitudinal strain as well as circumferential strain (CS) of the ascending aorta as a proxy measurement of aortic compliance.ResultsThe study comprised 139 cases of TAA aneurysms (52.5% females) with a mean age of 50 ± 14.8 years with 45 age and gender matched controls. Most cases (95%) were of African ethnicity. The main etiologies were hypertension (41.7%), HIV (36.6%), connective tissue disease (10.7%), congenital (2.2%) and mixed pathologies (8.6%). Two-thirds of patients (69.7%) presented in heart failure, 10% presented with aortic dissection. Thirty percent of the patients were classified as New York Heart Association (NYHA) class I, 59.7% NYHA II, 8.6% NYHA III and two patients NYHA class IV. Echocardiography revealed enlarged aortic dimensions compared to controls (P &lt; 0.001). TAA aneurysms were complicated by severe aortic regurgitation (AR) in half (50.3%) of patients, moderate AR in 25.8%, and mild AR in 14.3%. The mean LV ejection fraction (46.9 ± 12.7%) was reduced compared to controls (P &lt; 0.001). Aortic CS was reduced compared to controls [4.4 (3.2–6.2) % vs. 9.0 (7.1–13.4) %, P &lt; 0.001]. Aortic stiffness was higher in the aortic aneurysm group compared to controls (15.39 ± 20.65 vs. 5.04 ± 2.09, P = 0.001). LV longitudinal strain (−13.9 ± 3.9% vs. 18.1 ± 6.7%), basal CS (−13.9 ± 5.6% vs. −17.9 ± 5.8%) and apical CS (−8.7 ± 8.5% vs. −30.6 ± 3.8%) were reduced compared to controls (P &lt; 0.001). Most patients were on diuretic and anti-remodeling therapy. Surgery was performed in 29.4% and overall mortality was 7.9%. Mortality for acute aortic dissection was 40%.ConclusionTAA aneurysms associated with hypertension and HIV are common in this predominantly African female population and are associated with considerable morbidity and mortality. Two-dimensional echocardiography and advanced strain imaging are potential tools for detecting and risk stratifying TAA aneurysms.
The interaction between uric acid and high-density lipoprotein cholesterol on the prognosis of patients with acute myocardial infarction
Authors: Yang Yu , Zhang Jian , Jia Lin , Su Jiannan , Ma Mengqing , Lin Xianhe 
Published: July 2023

BackgroundThe significance of uric acid (UA) and high-density lipoprotein cholesterol (HDL-C) in the prognosis of acute myocardial infarction (AMI) remains controversial. This study investigated the effect of the interaction between UA and HDL-C on the prognosis of patients with AMI.MethodsIn total, 480 patients with AMI were included in this study. Baseline and follow-up data were collected, and the primary endpoint was major adverse cardiovascular events (MACE). The secondary endpoint was all-cause death. Both additive and multiplicative interactions were calculated to evaluate their interaction with prognosis. Then, the impact of UA and HDL-C ratio (UHR) on prognosis was assessed.ResultsOver a median follow-up period of 41 (30,46) months, 136 (28.3%) MACEs, and 44 (9.2%) deaths were recorded. There was a positive additive interaction between UA and HDL-C for MACEs. The attributable proportion (AP) showed that 46% of the estimated effect (MACE in patients) was attributable to this interaction. The synergy index (SI) was 2.04 (1.07,3.88) for MACE, indicating that the risk for patients presenting with both risk factors was greater than the sum of the risk factors alone. Multivariate Cox regression analysis revealed that UHR independently predicted MACEs and mortality. Kaplan–Meier survival curves according to tertiles of UHR showed statistically significant differences in MACE (log-rank test, P &lt; 0.001). Receiver operating characteristic (ROC) analysis showed that the area under the curve (AUC) of UHR for predicting MACE was 0.716.ConclusionThe coexistence of high UA and low HDL-C has a synergistic effect and provides further information for risk stratification of patients with AMI. UHR is a simple and easily available prognostic indicator independent of traditional risk factors.
Hilar/mediastinal and cutaneous drug-induced sarcoidosis-like reaction associated with immune checkpoint inhibitors in metastatic colorectal cancer: a case report
Authors: Sagawa Tamotsu , Sato Yasushi , Nagashima Hiroyuki , Takada Kohichi , Takahashi Mamoru , Hirakawa Masahiro , Hamaguchi Kyoko , Tamura Fumito , Fujikawa Koshi , Okamoto Koichi , Kawano Yutaka , Sogabe Masahiro , Miyamoto Hiroshi , Takayama Tetsuji 
Published: July 2023

BackgroundImmune checkpoint inhibitors (ICIs) are the standard treatment for metastatic colorectal cancer (mCRC) with high microsatellite instability (MSI-H). Among immune-related adverse events (irAEs), drug-induced sarcoidosis-like reactions (DISR) are often difficult to differentiate from cancer progression.Main BodyThis is a case of a woman in her mid-60s, with mCRC (RAS wild/BRAF mutant/MSI-H) and abdominal lymph node metastasis, treated with four courses of ipilimumab + nivolumab every 3 weeks, followed by nivolumab every 2 weeks as third-line treatment. After treatment, the original lymph node metastases shrank, but hilar/mediastinal lymph nodes appeared. Endoscopic ultrasound-guided fine-needle aspiration of these lymph nodes revealed multiple epithelioid granulomas without necrosis, indicating a sarcoidosis-like reaction. Fluorodeoxyglucose-positron emission tomography scan showed abnormal subcutaneous accumulation in bilateral forearms and bilateral knee joints. Biopsy of the cutaneous lesions was also performed, which revealed epithelioid granulomas. As the patient had no symptoms in other organs, no specific therapeutic intervention was administered. After the discontinuation of immunotherapy, the sarcoidosis-like reaction regressed without cancer relapse.ConclusionsClinicians should be aware of the possibility of DISR as an irAE during the ICI treatment of mCRC. In suspected cases of DISR following ICI therapy, it is important to differentiate between cancer progression and DISR through histological diagnosis for the subsequent strategy, as radiological and serological findings are not definitive.
Pediatric adenovirus pneumonia: clinical practice and current treatment
Authors: Zhang Jie , Zhu Yiting , Zhou Yiyang , Gao Fei , Qiu Xinhui , Li Jianshun , Yuan Hao , Jin Wenwen , Lin Wei 
Published: July 2023

Graphical abstractIn this review, we lay emphasis on the pathogenic mechanism, early recognition and treatment strategies of severe pediatric adenovirus pneumonia. The pathogenic mechanism of adenovirus is divided into three parts, direct damage to the target cells, inflammatory cytokines release and immune evasion of the virus. Indicators including age, clinical manifestations, imaging features and laboratory tests play an essential role in the early identification. Current treatment strategies are comprised of anti-viral drugs, respiratory support and bronchoscopy, continuous blood purification, immuno-regulation therapy and supportive care.
The disparities in prognostic prediction and annualized hazard function in different molecular subtypes between young Chinese and White American women with breast cancer
Authors: Zeng Yuanyuan , Wang Jun , Zhong Xiaorong , Xiang Zhongzheng , Yang Tian , Yu Siting , Dai Zelei , Xu Ningyue , Liu Lei 
Published: July 2023

Background and objectivesThe prognostic disparities in different molecular subtypes between young Chinese and White American breast cancer patients remain unclear. The goal of this study was to explore the prognostic differences in different molecular subtypes between Chinese and White American patients aged ≤ 40 years.MethodsWe included Chinese and White female breast cancer patients at or under the age of 40 from the Surveillance, Epidemiology, and End Results database (SEER) and the West China Hospital of Sichuan University. The chi-square test, log-rank test, and Cox proportional hazards model were employed to evaluate the distribution and survival disparities in the two racial/ethnic cohorts and different molecular subtypes. An annualized hazard function was used to calculate the annual failure rate among different molecular subtypes.ResultsThis study included 20,859 female breast cancer patients at or under the age of 40, of whom 18,400 were White women and 2,459 were Chinese women. With a median follow-up time of 47 months, the 5-year breast cancer-specific survival (BCSS) rates for young Chinese and White women were 93.9% and 90.0%, respectively (P&lt; 0.001). Molecular subtype was found to be a significant predictor in both young Chinese and White patients (P&lt; 0.001), but different trends were observed in the two racial/ethnic cohorts when exploring the association between BCSS and molecular subtypes. Among young White patients, the hormone receptor (HoR) (+)/epidermal growth factor receptor 2 (HER2) (+) subtype had the best 5-year BCSS rate, while in young Chinese patients, the HoR (+)/HER2 (+) and HoR (+)/HER2 (-) showed comparable survival curves and both showed superior 5-year BCSS than other subtypes. Stratification by molecular subtypes, young Chinese patients demonstrated a superior 5-year BCSS in HoR (+)/HER2 (-) (96.3% vs 92.9%, P&lt; 0.001) and triple-negative subtypes (88% vs 81.7%, P= 0.006) compared to young White American patients, while no significant differences were found in HoR (+)/HER2 (+) and HER2 enriched tumors. The annual hazard function for BCSS showed that there were significantly different trends in the HoR (+)/HER2 (-) and HoR (+)/HER2 (+) subtypes between young Chinese and White patients.ConclusionsThere are disparities in prognosis and annualized hazard function between young Chinese and White females with breast cancer in different molecular subtypes.
Case Report: Combined pembrolizumab, 5-fluorouracil, and cisplatin therapy were remarkably effective in p16-positive squamous cell carcinoma of unknown primary
Authors: Suzuki Risako , Hamada Kazuyuki , Ohkuma Ryotaro , Homma Mayumi , Tsurui Toshiaki , Iriguchi Nana , Ishiguro Tomoyuki , Hirasawa Yuya , Ariizumi Hirotsugu , Kubota Yutaro , Horiike Atsushi , Yoshimura Kiyoshi , Wada Satoshi , Yamochi Toshiko , Tsunoda Takuya 
Published: July 2023

BackgroundCancer of unknown primary (CUP) is a malignant tumor without a known primary lesion with a frequency of 3−5%. It can be divided into favorable and unfavorable prognosis subsets. While recommended treatments are available for the former group, there is no established treatment for the latter. Here, we report the effective treatment of a 32-year-old woman with p16-positive squamous cell CUP with pembrolizumab plus 5-fluorouracil and cisplatin therapy.Case presentationA 32-year-old woman presented with metastatic lesions in the liver, lung, bone, cervical region, abdominal region, and pelvic lymph nodes. She was diagnosed with p16-positive squamous cell carcinoma of unknown primary origin. The patient received pembrolizumab plus 5-fluorouracil and cisplatin therapy, which markedly reduced the metastasis and improved her Eastern Cooperative Oncology Group performance status after two courses.ConclusionThis case report highlights the potential of pembrolizumab plus 5-fluorouracil and cisplatin therapy for treating CUP with an unfavorable prognosis. p16 positivity is worth examining for squamous cell carcinoma of unknown primary origin, and if present, this therapy should be considered a promising treatment option.
Identifying novel candidate compounds for therapeutic strategies in retinopathy of prematurity via computational drug-gene association analysis
Authors: Xie Edward F. , Hilkert Rodriguez Sarah , Xie Bingqing , D’Souza Mark , Reem Gonnah , Sulakhe Dinanath , Skondra Dimitra 
Published: July 2023

PurposeRetinopathy of prematurity (ROP) is the leading cause of preventable childhood blindness worldwide. Although interventions such as anti-VEGF and laser have high success rates in treating severe ROP, current treatment and preventative strategies still have their limitations. Thus, we aim to identify drugs and chemicals for ROP with comprehensive safety profiles and tolerability using a computational bioinformatics approach.MethodsWe generated a list of genes associated with ROP to date by querying PubMed Gene which draws from animal models, human studies, and genomic studies in the NCBI database. Gene enrichment analysis was performed on the ROP gene list with the ToppGene program which draws from multiple drug-gene interaction databases to predict compounds with significant associations to the ROP gene list. Compounds with significant toxicities or without known clinical indications were filtered out from the final drug list.ResultsThe NCBI query identified 47 ROP genes with pharmacologic annotations present in ToppGene. Enrichment analysis revealed multiple drugs and chemical compounds related to the ROP gene list. The top ten most significant compounds associated with ROP include ascorbic acid, simvastatin, acetylcysteine, niacin, castor oil, penicillamine, curcumin, losartan, capsaicin, and metformin. Antioxidants, NSAIDs, antihypertensives, and anti-diabetics are the most common top drug classes derived from this analysis, and many of these compounds have potential to be readily repurposed for ROP as new prevention and treatment strategies.ConclusionThis bioinformatics analysis creates an unbiased approach for drug discovery by identifying compounds associated to the known genes and pathways of ROP. While predictions from bioinformatic studies require preclinical/clinical studies to validate their results, this technique could certainly guide future investigations for pathologies like ROP.
The development and validation of the Chinese safety climate scale using the item-response theory approach
Authors: Lyu Xiaokang , Zhao Binlin , Yang Tingting , Zhao Li 
Published: July 2023

IntroductionTo develop a valid and practical tool to measure the safety climate in China, and further raise awareness of it in Chinese industries, we developed the Chinese safety climate scale (including two subscales at the levels of organization and group separately) based on the work of Huang et al. in 2017.MethodsA descriptive survey with the convenience sampling method was conducted in Shanghai Disney Resort, China. A sample of 1,570 employees was involved in the final data analyses. The item response theory (IRT) analyses with graded response models were conducted using.ResultsThe unidimensionality and local independence assumption were held. The Cronbach’s α of organization- and group- level safety climate subscale was 0.912 and 0.937, respectively. The confirmatory factor analysis (CFA) showed good model fit for a one-factor model of the organization-level safety climate subscale, χ2 (df = 20) = 129.158, p &lt; 0.001, CFI = 0.994, TLI = 0.992, NFI = 0.993, IFI = 0.994, RMSEA = 0.059, 90% CI = (0.050, 0.069), and SRMR = 0.048. A one-factor model also fits well for the group-level safety climate subscale, χ2 (df = 44) = 219.727, p &lt; 0.001, CFI = 0.996, TLI = 0.9925, NFI = 0.995, IFI = 0.996, RMSEA = 0.050, 90% CI = (0.044, 0.057), and SRMR = 0.046. Discrimination and difficulty parameters showed that all items effectively spanned the range of the latent trait and could successfully separate participants at different safety climate levels. Items in the organization-level and group-level Chinese safety climate subscales had significantly different discrimination parameters, fitted well with the models, and had a substantive relationship with the latent traits.DiscussionThe Chinese safety climate scale was reliable and valid overall. They can facilitate the research and survey regarding the safety climate in China.
Dutch workers’ attitudes towards having a coworker with mental health issues or illness: a latent class analysis
Authors: van Beukering I. E. , Sampogna G. , Bakker M. , Joosen M. C. W. , Dewa C. S. , van Weeghel J. , Henderson C. , Brouwers E. P. M. 
Published: July 2023

IntroductionWorkplace mental health stigma is a major problem as it can lead to adverse occupational outcomes and reduced well-being. Although workplace climate is largely determined by managers and co-workers, the role of co-workers in workplace stigma is understudied. Therefore, the aims are: (1) to examine knowledge and attitudes towards having a coworker with Mental Health Issues or Illness (MHI), especially concerning the desire for social distance, (2) to identify distinct subgroups of workers based on their potential concerns towards having a coworker with MHI, and (3) to characterize these subgroups in terms of knowledge, attitudes, and background characteristics.Materials and methodsA cross-sectional survey was conducted among a nationally representative internet panel of 1,224 Dutch workers who had paid jobs and did not hold management positions. Descriptive statistics and a three-step approach Latent Class Analysis (LCA) were used to address the research aims.ResultsConcerning the desire for social distance, 41.9% of Dutch workers indicated they did not want to have a close colleague with MHI, and 64.1% did not want to work for a higher-ranking manager who had MHI. In contrast however, most workers did not have negative experiences with interacting with coworkers with MHI (92.6%). Next, five distinct subgroups (SG) of workers were identified: two subgroups with few concerns towards having a coworker with MHI (SG1 and SG2; 51.8% of the respondents), one subgroup with average concerns (SG3; 22.7% of the respondents), and two subgroups with more concerns (SG4 and SG5; 25.6% of the respondents). Four out of five subgroups showed a high tendency towards the desire for social distance. Nevertheless, even in the subgroups with more concerns, (almost) half of the respondents were willing to learn more about how to best deal with coworkers with MHI. No significant differences were found between the subgroups on background characteristics.DiscussionThe high tendency to the desire for social distance seems to contrast with the low number of respondents who personally had negative experiences with workers with MHI in the workplace. This suggests that the tendency to socially exclude this group was not based on their own experience. The finding that a large group of respondents indicated to want to learn more about how to deal with a co-worker with MHI is promising. Destigmatizing interventions in the workplace are needed in order to create more inclusive workplaces to improve sustained employment of people with MHI. These interventions should focus on increasing the knowledge of workers about how to best communicate and deal with coworkers with MHI, they do not need to differentiate in background variables of workers.