bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effects of perceived network characteristics on knowledge exchange in virtual communities
Authors: Shin Seung Kyoon , Kang Kyungwoo , Sanders G. Lawrence 
Published: February 2023

AbstractUnderstanding virtual community (VC) networks is essential because the characteristics of these networks play a fundamental role in knowledge exchange. This survey‐based study proposes two network‐related antecedents: perceived closeness with VC members (PCL) and perceived connectedness with VC members (PCN). Using a structural equation modeling approach, we examined the two antecedents' associations with the knowledge‐exchange drivers that, in turn, are related to two endogenous variables: intention to acquire knowledge and intention to share knowledge. The results of our bootstrapping mediation tests suggest that the perceived network characteristics indirectly influence members' knowledge‐exchange intentions through mediators such as identification, knowledge self‐efficacy, reputation, and shared vision. We conclude that PCN can positively influence the four mediators and is a key network characteristic that facilitates knowledge exchange in virtual spaces. By studying the antecedents of users' intentions to share and acquire knowledge, this research provides a holistic view of information exchange on VCs.
Should a benevolent government provide public goods if it cannot commit?
Authors: Silva Francisco 
Published: February 2023

AbstractI compare two different systems of provision of binary public goods: a centralized system, operated by a benevolent government that has limited commitment power; and a decentralized system, based on voluntary contributions, where agents can communicate but cannot write contracts. I show that any ex‐post individually rational allocation that is implementable by the centralized system is also implementable by the decentralized system. This suggests that when the public good provision problem is merely an informational one, as is the case with binary public goods, a decentralized system may perform better.
Clinical, biological, and outcome features of P2RY8‐CRLF2 and CRLF2 over‐expression in pediatric B‐cell precursor acute lymphoblastic leukemia according to the CCLG‐ALL 2008 and 2018 protocol
Authors: Wang Ying , Li Jun , Xue Tian‐Lin , Tian Shuo , Yue Zhi‐Xia , Liu Shu‐Guang , Gao Chao 
Published: February 2023

AbstractObjectivesCRLF2 alterations are associated with B‐cell precursor acute lymphoblastic leukemia (BCP‐ALL). This study aimed to explore the clinical, biological, and outcome features of pediatric BCP‐ALL with CRLF2 abnormalities.MethodsThis study enrolled 630 childhood BCP‐ALLs treated on CCLG‐ALL 2008 or 2018 protocol. P2RY8‐CRLF2 was determined by Sanger sequencing and CRLF2 expression was evaluated by qRT‐PCR. The correlation between clinical, biological features and outcomes with P2RY8‐CRLF2 or CRLF2 over‐expression were analyzed.ResultsP2RY8‐CRLF2 and CRLF2 over‐expression were found in 3.33% and 5.71% respectively. P2RY8‐CRLF2 was associated with male, higher frequency of CD7 expression, high WBC and MRD before consolidation. CRLF2 over‐expression showed ETV6‐RUNX1−, higher frequency of CD22, CD34, CD66c, CD86 expression, hyperdiploidy and high MRD at early treatment. The lower overall survival (OS) was found in patients with P2RY8‐CRLF2 and confined only in IR group. Furthermore, adverse event‐free survival and OS of P2RY8‐CRLF2 were discovered comparing to those without known fusions or treated on CCLG‐ALL 2008 protocol. However, P2RY8‐CRLF2 was not confirmed as independent prognostic factors and no prognostic impact of CRLF2 over‐expression was found.ConclusionsThese findings indicate P2RY8‐CRLF2 identifies a subset of patients with specific features and adverse outcomes that could be improved by risk‐directed treatment.
Current and future distribution of a parasite with complex life cycle under global change scenarios: Echinococcus multilocularis in Europe
Authors: Cenni Lucia , Simoncini Andrea , Massetti Luciano , Rizzoli Annapaola , Hauffe Heidi C. , Massolo Alessandro 
Published: February 2023

AbstractGlobal change is expected to have complex effects on the distribution and transmission patterns of zoonotic parasites. Modelling habitat suitability for parasites with complex life cycles is essential to further our understanding of how disease systems respond to environmental changes, and to make spatial predictions of their future distributions. However, the limited availability of high quality occurrence data with high spatial resolution often constrains these investigations. Using 449 reliable occurrence records for Echinococcus multilocularis from across Europe published over the last 35 years, we modelled habitat suitability for this parasite, the aetiological agent of alveolar echinococcosis, in order to describe its environmental niche, predict its current and future distribution under three global change scenarios, and quantify the probability of occurrence for each European country. Using a machine learning approach, we developed large‐scale (25 × 25 km) species distribution models based on seven sets of predictors, each set representing a distinct biological hypothesis supported by current knowledge of the autecology of the parasite. The best‐supported hypothesis included climatic, orographic and land‐use/land‐cover variables such as the temperature of the coldest quarter, forest cover, urban cover and the precipitation seasonality. Future projections suggested the appearance of highly suitable areas for E. multilocularis towards northern latitudes and in the whole Alpine region under all scenarios, while decreases in habitat suitability were predicted for central Europe. Our spatially explicit predictions of habitat suitability shed light on the complex responses of parasites to ongoing global changes.
Exploring the roles of prostanoids, leukotriens, and dietary fatty acids in cutaneous inflammatory diseases: Insights from pharmacological and genetic approaches
Authors: Honda Tetsuya , Kabashima Kenji , Kunisawa Jun 
Published: February 2023

SummaryProstanoids and leukotrienes (LTs) are representative of ω6 fatty acid‐derived metabolites that exert their actions through specific receptors on the cell surface. These lipid mediators, being unstable in vivo, act locally at their production sites; thus, their physiological functions remain unclear. However, recent pharmacological and genetic approaches using experimental murine models have provided significant insights into the roles of these lipid mediators in various pathophysiological conditions, including cutaneous inflammatory diseases. These lipid mediators act not only through signaling by themselves but also by potentiating the signaling of other chemical mediators, such as cytokines and chemokines. For instance, prostaglandin E2‐EP4 and LTB4‐BLT1 signaling on cutaneous dendritic cells substantially facilitate their chemokine‐induced migration ability into the skin and play critical roles in the priming and/or activation of antigen‐specific effector T cells in the skin. In addition to these ω6 fatty acid‐derived metabolites, various ω3 fatty acid‐derived metabolites regulate skin immune cell functions, and some exert potent anti‐inflammatory functions. Lipid mediators act as modulators of cutaneous immune responses, and manipulating the signaling from lipid mediators has the potential as a novel therapeutic approach for human skin diseases.
Optimal Treatment Regimes: A Review and Empirical Comparison
Authors: Li Zhen , Chen Jie , Laber Eric , Liu Fang , Baumgartner Richard 
Published: February 2023

SummaryA treatment regime is a sequence of decision rules, one per decision point, that maps accumulated patient information to a recommended intervention. An optimal treatment regime maximises expected cumulative utility if applied to select interventions in a population of interest. As a treatment regime seeks to improve the quality of healthcare by individualising treatment, it can be viewed as an approach to formalising precision medicine. Increased interest and investment in precision medicine has led to a surge of methodological research focusing on estimation and evaluation of optimal treatment regimes from observational and/or randomised studies. These methods are becoming commonplace in biomedical research, although guidance about how to choose among existing methods in practice has been somewhat limited. The purpose of this review is to describe some of the most commonly used methods for estimation of an optimal treatment regime, and to compare these estimators in a series of simulation experiments and applications to real data. The results of these simulations along with the theoretical/methodological properties of these estimators are used to form recommendations for applied researchers.
Development and validation of a patient participation scale
Authors: Song Mira , Kim Miyoung 
Published: February 2023

AbstractAimsTo develop an instrument measuring patient participation in healthcare and verify the validity and reliability of the patient participation scale (PPS).DesignA methodological study using instrument‐development and instrument‐verification phases.MethodsData were collected from January to August 2021. The instrument‐development phase identified preliminary items through literature reviews and interviews with 17 patients and nine healthcare providers. The instrument‐verification phase surveyed 312 internal medicine patients from four tertiary general hospitals. Exploratory factor analysis was performed; Pearson correlation and Cronbach's α coefficients were checked.ResultsThe PPS comprised 21 items divided into four themes: ‘sharing of information and knowledge’, ‘performing proactive self‐management activities’, ‘establishing mutual trust relationships’ and ‘partaking in the decision‐making process’, explaining 61.9% of the variance. The correlation coefficients for criterion‐related validity was .820 (p < .001) and Cronbach's α coefficients for reliability was .92.ConclusionThe PPS can reasonably and reliably measure the participation levels that patients experience in their treatment and care process.ImpactThis PPS can help nurses encourage internal medicine patients to participate in their treatment and care.
Psychosocial‐behavioural interventions for school‐aged children with intellectual disabilities: A systematic review of randomised control trials
Authors: Windsor Catriona , Zhang Tingwei , Wilson Nathan J. , Blyth Katrina , Ballentine Natalie , Speyer Renée 
Published: February 2023

AbstractBackgroundEvidence‐based interventions are essential for school‐aged children with intellectual disabilities to facilitate development and promote future independence.MethodsUsing a PRISMA approach, systematic screening of five databases was undertaken. Original randomised controlled studies with psychosocial‐behavioural interventions were included where participants were school aged (5‐18 yrs) with documented intellectual disability. Study methodology was assessed using the Cochrane RoB 2 tool.ResultsTwo thousand three hundred and three records were screened with 27 studies included. Studies mainly included primary school participants with mild intellectual disabilities. Most interventions focused on intellectual skills (e.g., memory, attention, literacy and mathematics) followed by adaptive skills (e.g., daily living, communication, social and education/vocation) and some focused on a combination of these.ConclusionThis review highlights the gap in evidence‐base for social, communication and education/vocation interventions with school‐aged children with moderate and severe intellectual disability. Future RCTs that bridge this knowledge gap across ages and ability are required for best practice.
Unravelling the factors affecting multiple facets of macroinvertebrate beta diversity in the World's Third Pole
Authors: Li Zhengfei , Heino Jani , Zhang Junqian , Ge Yihao , Liu Zhenyuan , Xie Zhicai 
Published: February 2023

AbstractAimDisentangling how stochastic and deterministic processes contribute to variation in beta diversity is a common goal for ecologists and biogeographers. However, such studies are scarce in alpine streams, especially when different diversity facets are considered. Here, we combined different approaches to examine the drivers of taxonomic, phylogenetic and functional beta diversities, and discussed how our results can inform community assembly and biodiversity conservation in Tibetan streams.LocationTibet plateau.TaxonMacroinvertebrates.MethodsWe first partitioned multiple facets of beta diversity (Btotal) into species replacement (Brepl) and richness difference (Brich) as well as local (LCBD) or species (SCBD) contributions. Then, we applied ordination methods to examine the relative importance of local, climatic and spatial factors on Btotal, Brepl and Brich, respectively. We explored community assembly rules using null models based on trait and phylogeny structure.ResultsBtotal displayed high values and was primarily driven by Brepl. Local, climatic and spatial factors were poor predictors of the different facets of beta diversity. Null models showed that the diversity metrics did not differ from those of null expectations, suggesting that most individual streams might be occupied by species that were merely random draws from the functional or phylogenetic pools available in this region. Partitioning beta diversity into LCBD and SCBD implied that the upper canyon streams were more unique than those at lower elevations and can be valuable for biodiversity conservation.Main ConclusionsAnalysing multiple facets of beta diversity provide important insights into community assembly that cannot be acquired by focusing on taxonomic diversity only. Using a multi‐faceted approach involving species, phylogenetic and trait data, our study not only sheds light on the assembly mechanisms of macroinvertebrate communities in alpine streams, but also bring inspirations for biodiversity conservation in the ‘World's Third Pole’ that is highly sensitive to global change.
Early detection of Pseudocapillaria tomentosa by qPCR in four lines of zebrafish, Danio rerio (Hamilton 1882)
Authors: Schuster Corbin J. , Leong Connor , Kasschau Kristin D. , Sharpton Thomas J. , Kent Michael L. 
Published: February 2023

AbstractThe intestinal nematode Pseudocapillaria tomentosa in zebrafish (Danio rerio) causes profound intestinal lesions, emaciation and death and is a promoter of a common intestinal cancer in zebrafish. This nematode has been detected in zebrafish from about 15% of the laboratories. Adult worms are readily detected about 3 weeks after exposure by either histology or wet mount preparations of the intestine, and larval worms are inconsistently observed in fish before this time. A quantitative PCR (qPCR) test was recently developed to detect the worm in fish and water, and here we determined that the test on zebrafish intestines was effective for earlier detection. Four lines of zebrafish (AB, TU, 5D and Casper) were experimentally infected and evaluated by wet mounts and qPCR at 8, 15‐, 22‐, 31‐ and 44‐day post‐exposure (dpe). At the first two time points, only 8% of the wet mounts from exposed fish were identified as infected, while the same intestines screened by qPCR showed 78% positivity, with low and consistent cycle threshold (Ct) values at these times. Wet mounts at later time points showed a high prevalence of infection, but this was still surpassed by qPCR.
The association of vitamin D supplementation and serum vitamin D levels with physical activity in older adults: Results from a randomized trial
Authors: Schrack Jennifer A. , Cai Yurun , Urbanek Jacek K. , Wanigatunga Amal A. , Mitchell Christine M. , Miller Edgar R. , Guralnik Jack M. , Juraschek Stephen P. , Michos Erin D. , Roth David L. , Appel Lawrence J. 
Published: February 2023

AbstractBackgroundTo assess whether vitamin D3 supplementation attenuates the decline in daily physical activity in low‐functioning adults at risk for falls.MethodsSecondary data analyses of STURDY (Study to Understand Fall Reduction and Vitamin D in You), a response‐adaptive randomized clinical trial. Participants included 571 adults aged 70 years and older with baseline serum 25(OH)D levels of 10–29 ng/mL and elevated fall risk, who wore a wrist accelerometer at baseline and at least one follow‐up visit and were randomized to receive: 200 IU/day (control), 1000, 2000, or 4000 IU/day of vitamin D3. Objective physical activity quantities and patterns (total daily activity counts, active minutes/day, and activity fragmentation) were measured for 7‐days, 24‐h/day, in the free‐living environment using the Actigraph GT9x over up to 24‐months of follow‐up.ResultsIn adjusted models, physical activity quantities declined (p < 0.001) and became more fragmented, or “broken up”, (p = 0.017) over time. Supplementation with vitamin D3 did not attenuate this decline. Changes in physical activity were more rapid among those with baseline serum 25(OH)D <20 ng/mL compared to those with baseline 25(OH)D levels of 20–29 ng/mL (time*baseline 25(OH)D, p < 0.05).ConclusionIn low‐functioning older adults with serum 25(OH)D levels 10–29 ng/mL, vitamin D3 supplementation of 1000 IU/day or higher did not attenuate declines in physical activity compared with 200 IU/day. Those with baseline 25(OH)D <20 ng/mL showed accelerated declines in physical activity. Alternative interventions to supplementation are needed to curb declines in physical activity in older adults with low serum 25(OH)D.
Comparing the accuracy of occlusal vertical dimension transfer in CAD–CAM dentures
Authors: Satin Sara R. , Goodacre Brian J. , Masri Radi 
Published: February 2023

AbstractPurposeThere are different methods to transfer occlusal vertical dimension (OVD) when fabricating complete dentures, but it is not clear which method yields the most accurate transfer. This study investigated the accuracy of transferring the OVD of the maxillary/mandibular relationship when designing and fabricating digital dentures by evaluating two commonly used workflows: duplicate dentures (DDs) and occlusion rims (ORs).Materials and methodsMounted edentulous casts were used to simulate a completely edentulous patient. These casts were used in two workflows: (1) DD workflow where complete dentures were fabricated and relined (n = 15), and (2) OR where final impressions and ORs were constructed (n = 15). Relined dentures and ORs with fiduciary markers were then scanned and virtually articulated, then exported as STL files. A scan of the articulated casts (simulated patients) with fiduciary markers embedded was also exported as an STL file and used as a control. STL files for each workflow were superimposed over the control and analyzed in 3D inspection software (Geomagic Control X, 3D Systems, NC) for deviations (mm) at three different locations. Average 3D deviations were compared among the groups using a two‐way ANOVA (α—0.05).ResultsThe average deviation for OR was significantly larger than DD at all locations of measurement [F = 46.00, p < 0.0001]. The majority of the measurements (98.9%) had a positive deviation value, indicating increased OVD. The overall deviation for the OR group from the control was 0.72 ± 0.13 mm versus 0.45 ± 0.23 mm for the DD group. There was no difference in deviation between the points of measurement and no interaction between the location and method [F = 0.02, p < 0.98].ConclusionsThe DD workflow exhibited less deviation in the transfer of OVD than the OR workflow. However, the deviation was small and may not be clinically significant.
The Association of School Learning Environment With Adolescent Health Behaviors
Authors: Mulitauopele Christine , Israel Whitney , Rosenberg Sophie , Brooks‐Russell Ashley , Ma Ming , Dinger Mary K. 
Published: February 2023

ABSTRACTBACKGROUNDIn 2020, schools shifted to remote learning in response to mitigating COVID‐19. Since then, students have fluctuated between in‐person and remote learning environments. Changes to instructional models raise questions about the impact on health.METHODSThis study leveraged a statewide surveillance system (Healthy Kids Colorado Survey) to examine the relationship between learning environment and adolescent health. The survey was administered in Fall 2020 to 26 high schools, resulting in 4564 respondents.RESULTSOverall, results suggested positive and negative associations between the 3 learning environments. Notably, as compared to in‐person students, hybrid and remote students reported more stress (OR = 1.82, p < .001; OR = 1.41, p = .001), less school connectedness (OR = 0.71 and 0.61, p < .001); remote students reported more parental abuse (OR = 1.33, p = .010) and less alcohol consumption (OR = 0.61, p < .001).CONCLUSIONThis study may be used to better understand risk and protective factors experienced by youth at school and home with the goal of improving prevention strategies.
An interdisciplinary telemedicine innovation to enhance pediatric diabetes care in rural communities: A proposed practice initiative
Authors: Stallings Dana E. , Duetsch Jean R. , Gustin Tina S. , Goode Victoria M. 
Published: February 2023

AbstractPurposeThe COVID‐19 pandemic highlighted disparities in healthcare access and outcomes, particularly among individuals with chronic conditions. A positive outcome of the pandemic was an increased use of telehealth and the creation of innovative models of care. In many organizations, nurses became the leaders for these new models. Before this change, pediatric medicine had far fewer telehealth models than adult medicine due to limited Medicaid reimbursement and equipment that was not designed with children in mind. This article describes a new model of care for children with diabetes. We will review how a nurse‐led initiative with the incorporation of telehealth modalities can improve access and outcomes while reducing cost. Successful models of care will be reviewed, as well as programmatic planning, financial implications, and regulatory considerations.ConclusionsIt is no longer necessary for families living in rural communities to drive long distances, missing school and work, to attend the frequent appointments needed for optimal management of pediatric diabetes. Telemedicine can bridge gaps in access to specialty care, and is feasible, reimbursable, and well‐accepted by families and providers.Practice ImplicationsNurses in both primary care and pediatric specialty offices can initiate and support innovative telehealth models of care, such as this proposal. To win the backing of practice leadership, the availability of cost‐effective videoconferencing equipment and software, improvements in telehealth reimbursement prompted by the pandemic, and enhanced patient and parent satisfaction and outcomes should be emphasized.