bluuebunny/crossref_metadata_2025_split huggingface dataset:
AI Adoption Challenges in Family-Owned Firms: A Case Study
Authors: Worek Maija , Aaltonen Päivi 
Published: January 2025

Abstract
AI transformation is reshaping organizations and societies, pushing firms to embrace new technologies. In the presence of abundant technology, personnel, and personnel management becomes increasingly crucial in creating a competitive edge. Family firms, making up a significant portion of businesses worldwide, serve as an example of industrial firms with existing leveraged emphasis on softer values, yet face significant challenges in AI adoption. Various models used to understand digital transformation, such as the Technology-Organization-Environment model and the Technology Acceptance Model, may not adequately explain the complexities involved in AI adoption, particularly regarding familial factors like trust and collaboration. Family firms are often slow in adopting technology due to concentrated ownership, risk aversion, and a focus on non-financial goals. This study explores the specific challenges family-owned businesses experience in AI adoption and responses to these challenges. By examining five family-owned firms, the research aims to contribute to the understanding of technology adoption by identifying barriers and forming categories that can inform future studies on family firms and AI technology.
Mild acute biliary pancreatitis: still a surgical disease. A post-hoc analysis of the MANCTRA-1 international study
Authors: Cioffi Stefano Piero Bernardo , Spota Andrea , Virdis Francesco , Altomare Michele , Mingoli Andrea , Cimbanassi Stefania , Nava Francesca Laura , Nardi Silvana , Di Martino Marcello , Di Saverio Salomone , Ielpo Benedetto , Pata Francesco , Pellino Gianluca , Sartelli Massimo , Damaskos Dimitris , Coccolini Federico , Pisanu Adolfo , Catena Fausto , Podda Mauro ,   the MANCTRA-1 study group
Published: January 2025

Abstract

Background
The current standard of care for mild acute biliary pancreatitis (MABP) involves early laparoscopic cholecystectomy (ELC) to reduce the risk of recurrence. The MANCTRA-1 project revealed a knowledge-to-action gap and higher recurrence rates in patients admitted to medical wards, attributable to fewer ELCs being performed. The project estimated a 35% to 70% probability of narrowing this gap by 2025. This study evaluates the safety of suboptimal ELC implementation and identifies risk factors for recurrent acute biliary pancreatitis (RAP) in patients not undergoing ELC after an MABP episode.

Methods
We conducted a post-hoc analysis of the MANCTRA-1 registry, including MABP patients who did not undergo ELC during the index hospitalization, excluding those with related complications. The primary outcome was the 30-day hospital readmission rate due to RAP. We performed multivariable logistic regression to find risk factors associated with the primary outcome.

Results
Between January 2019 and December 2020, 1920, MABP patients from 150 centers were included in the study. The 30-day readmission rate due to RAP was 6%. Multivariable logistic regression found the admission to a medical ward (internal medicine or gastroenterology) (OR = 1.95, p = 0.001) and a positive COVID-19 test (OR = 3.08, p = 0.029) as independent risk factors for RAP.

Conclusion
Our analysis offers valuable insights into the management of MABP, particularly in centers where ELC cannot be fully implemented due to logistical and clinical constraints, worsened by the COVID-19 pandemic. Regardless of the admitting ward, prompt access to surgical care is crucial in reducing the risk of early recurrence, highlighting the need to implement surgical consultation pathways within MABP care bundles.
Taurine protection attenuates bisphenol-A-induced behavioral, neurochemical, and histopathological alterations in male rats
Authors: Nazmy Mohamed M. , Noor Neveen A. , Mohammed Faten F. , Khadrawy Yasser A. , Radwan Nasr M. 
Published: January 2025

Abstract
Due to the continuous exposure to bisphenol-A (BPA), the current study was conducted to evaluate taurine’s neuroprotective action against BPA’s adverse effect on the brain. Rats were grouped into control, BPA-treated rats, and taurine + BPA-treated rats. At the end of the 35-day treatment period, the memory of the rats was evaluated using the novel object test and the Y-maze test. An open-field test was used to measure motor activity. The changes in monoamines, monoamine oxidase (MAO), acetylcholinesterase (AChE), Na+,K+,ATPase, oxidative stress, caspase-3, and histopathology were evaluated in the cortical and hippocampal tissues of all groups. Data analysis by ANOVA revealed that BPA treatment induced motor hyperactivity and short- and long-term memory impairment. In the cortex, BPA decreased serotonin (5-HT), norepinephrine (NE), MAO, Na+,K+,ATPase, and nitric oxide (NO) and increased dopamine (DA), AChE, lipid peroxidation (MDA), glutathione (GSH), and caspase-3. In the hippocampus, BPA increased 5-HT, DA, NE, MAO, AChE, MDA, NO, GSH, and caspase-3 and decreased Na+,K+,ATPase. These neurochemical changes were accompanied by significant histopathological alterations. Taurine treatment prevented memory impairment and motor hyperactivity induced by BPA. Taurine attenuated the neurochemical changes, oxidative stress, and caspase-3 level. Taurine improved the histopathological change induced by BPA. In conclusion, taurine significantly prevented BPA-induced cognitive deficits, motor coordination impairments, neurotransmitter imbalances, histopathological alterations, oxidative stress, and apoptosis.
Liraglutide mitigates dexamethasone-induced fatty acid synthase (FASN) and the cluster of differentiation36 (CD36) expression: a potential treatment for glucocorticoid-induced non-alcoholic fatty liver disease (NAFLD)
Authors: Selim Dahshan Hassan , Mokhlis Hamada Ahmed , Elsayed Abdelrahman M. , Shatat Abdel-Aziz S. , Salama Salama Abdou , Ismail Raed Shahat 
Published: January 2025

Abstract
The clinical use of dexamethasone (DXM) is associated with the development of non-alcoholic fatty liver disease (NAFLD). However, the mechanisms by which DXM-induced NAFLD is still incompletely known. Therefore, the current study aims to test the hypothesis that DXM-induced NAFLD is mediated by dysregulation of key genes involved in lipid metabolism and liraglutide (LG) can ameliorate these effects. The histopathological and biochemical analysis assessed the effects of DXM and/or LG in liver tissue. The computational analysis was performed to detect the glucocorticoid response elements (GRE) in the promotor regions of FASN and CD36 genes. The effects of DXM and LG on the expression of FASN and CD36 were determined by real-time quantitative reverse transcription PCR (RT-qPCR), western blot (WB) and immunohistochemical (IHC) analyses. The NAFLD induced by high-fat diet (HFD) and DXM was manifested by increased levels of liver enzymes, deterioration of histological architecture of the liver tissue and accumulation of fat droplets. Computational analysis revealed that the promotor regions of FASN and CD36 harper several GRE. Most importantly, treatment with DXM decreased phosphorylated adenosine monophosphate-activated protein kinase (p-AMPK) levels, while LG upregulate it. In addition, treatment with DXM increased expression of FASN and CD36, whereas LG ameliorated these effects in a dose-dependent manner. DXM-induced NAFLD is mediated by upregulation of FASN and CD36 expression which may be attributed to GRE. LG coupling with DXM mitigates this induction by downregulating FASN and CD36 levels and therefore mitigates the development of NAFLD.
Exosomes derived from bone marrow mesenchymal stem cells ameliorate chemotherapeutically induced damage in rats’ parotid salivary gland
Authors: Zakaria Ahmed , Sultan Nessma , Nabil Nesreen , Elgamily Mahitabe 
Published: January 2025

Abstract

Objective
A nanometer-sized vesicles originating from bone marrow mesenchymal stem cells (BMMSCs), called exosomes, have been extensively recognized. This study defines the impact of BMMSCs and their derived exosomes on proliferation, apoptosis and oxidative stress (OS) levels of CP-induced parotid salivary gland damage.

Methods
BMMSCs were isolated from the tibia of four white albino rats and further characterized by flowcytometric analysis. BMMSCs-derived exosomes were harvested and underwent characterization using transmission electron microscopy (TEM), western blot analysis and BCA assay. Fifty-six healthy white albino male rats weighting from 200 to 250 g were allocated into 4 groups (n = 14); Group I, rats received phosphate buffered saline (PBS), group II, rats were intraperitoneally injected with CP, group III& IV received CP and after 3 days they were intravenously injected with either BMMSCs (group III) or BMMSCs-exosomes (group IV). Histological, and immunohistochemical studies using proliferating cell nuclear antigen (PCNA) were done after 7 and 14 days. The OS was measured using malondialdehyde (MDA) and apoptosis was measured by annexin V-FITC/PI.

Results
BMMSCs and exosomes treated groups showed better histological features approximating the normal architecture of the control group. The percentage of PCNA positively stained cells were significantly higher in the exosomes treated group in comparison to all other groups. MDA assay test revealed that the exosomes were able to reduce the OS when compared to the cell-based therapy using BMMSCs. Annexin V revealed that BMMSCs-exosomes significantly reduced the percentage of apoptotic cells compared to other treated groups.

Conclusions
BMMSCs-exosomes could improve the CP-induced cytotoxicity in rats’ parotid salivary gland.
Efgartigimod treatment for therapy-refractory autoimmune encephalitis with coexistent NMDAR and LGI1 antibodies: a case report and literature review
Authors: Xu Jiaming , Guo Zhenli , Zhao Jie , Chen Yun , Liu Zhijun , Wu Yan 
Published: January 2025

Abstract
The Fc receptor (FcRn) inhibitors can ameliorate autoimmune conditions such as myasthenia gravis through a rapid and specific clearance of serum IgG levels, and they also have potential for future use in a wider variety of antibody-mediated autoimmune diseases. Some patients with therapy-refractory autoimmune encephalitis (AE) continue to be unresponsive to initial and secondary treatment regimens. A 32-year-old male presented with predominant psychiatric symptoms and seizures, along with imaging evidence indicating multifocal cerebral cortical involvement. Neural antibody testing revealed dual positivity for N-methyl-D-aspartate receptor (NMDAR) and leucine-rich glioma-inactivated 1 (LGI1) antibodies in both serum and cerebrospinal fluid (CSF). Human leukocyte antigen (HLA) genotyping revealed the presence of the DQB1*03:01 and DQB1*06:01 alleles in the patient. Treatment with efgartigimod, the FcRn inhibitor, led to significant clinical improvements accompanied by a significant decrease in both anti-NMDAR and anti-LGI1 antibody levels. Herein, we report a rare case of therapy-refractory anti-NMDAR AE coexisting with positive LGI1 antibodies. Efgartigimod demonstrates promising potential for treating antibody-mediated AE.

Clinical trial number Not applicable.
Factors Associated with the Use of Complementary and Alternative Medicine in Rural Northern Victoria, Australia
Authors: Hamilton Andrew J. , Bourke Lisa , Ranmuthugala Geetha , Glenister Kristen M. , Simmons David 
Published: January 2025

Abstract
About one-third of Australians use the services of complementary and alternative medicine (CAM); but debate about the role of CAM in public healthcare is vociferous. Despite this, the mechanisms driving CAM healthcare choices are not well understood, especially in rural Australia. From 2016 to 2018, 2,679 persons from the Goulburn Valley, northern Victoria, were surveyed, 28% (755) of whom reporting visiting CAM practitioners. A Generalized Linear Mixed Model was used to assess associations between various socio-demographic variables and the use of CAM services. The strongest significant inverse (p < 0.05) association with CAM use overall was being unemployed, with markedly lower odds of using CAM than those employed full-time (OR 0.22 [0.12, 0.41]). The next strongest inverse relationship was being retired (OR 0.44 [0.30, 0.65]). The strongest positive associations were with English spoken at home (OR 2.38 [1.34, 4.24]), private health insurance (hospital cover) (1.57 [1.28, 1.91]), being Australian born (OR 1.61 [1.14, 2.28]), and female sex (1.25 [1.02, 1.52])). Females had significantly higher odds of using osteopathy than males (OR 1.98 [1.33, 2.96]) but there were no significant sex differences for chiropractic or massage. This is the first such study conducted solely for a rural Australian population. The drivers of CAM use differed from previous nation-wide studies and they varied across modalities. The factors identified here as being associated with CAM use could be used by CAM practitioners in developing person-centred services. Similarly, the findings are relevant to primary-care services in understanding what sectors of society might eschew conventional health care for CAM in rural regions, where health services are often limited.
Association of Hospital-Based Social Needs Interventions with Potentially Preventable Admissions
Authors: Knox Margae J. , Brewster Amanda L. , Ahern Jennifer , Shortell Stephen M. , Hague Emily L. , Rodriguez Hector P. 
Published: January 2025

Abstract

Background
External incentives increasingly encourage hospitals to address health-related social needs, yet limited evidence exists about whether social needs interventions are associated with quality indicators like potentially preventable admissions.

Objective
We analyze whether four hospital interventions—meal delivery, transportation to health services, mobile clinics, and community-oriented violence prevention programs—are associated with potentially preventable hospitalizations.

Design
Cross-sectional analysis of survey-based and claims-based data.

Participants
In total, 813 hospitals from 14 states, representing 6,003,739 adult all-payer hospital admissions.

Approach
This study merged 2017 Healthcare Cost Utilization Project State Inpatient Databases with 2017 American Hospital Association survey data. Generalized linear models for each of the four interventions were separately estimated to assess the association with potentially preventable hospitalizations, controlling for hospital and patient characteristics. Sensitivity analyses restricted regression modeling to adult Medicaid and Medicare beneficiaries.

Key Results
A minority (13%) of hospital admissions were potentially preventable. 24% of hospitals offered transportation to health services, 16% offered mobile clinic services, 16% offered violence prevention programs, and 9% offered meal delivery. In adjusted analyses, hospital meal delivery was associated with 1.1% lower predicted probability of a potentially preventable hospitalization (95% confidence interval (CI) −2.1% to −0.1%), with a stronger relationship among Medicaid beneficiaries (−2.3%, 95% CI −3.5% to −1.0%). Associations for other social needs interventions were not statistically significant.

Conclusions
Hospital meal delivery was associated with significantly lower probability of potentially preventable hospitalizations, with larger effects for Medicaid beneficiaries. Meal delivery may support hospital quality. More nuanced understanding about the reach of social needs interventions is needed to further examine the impact of these hospital-based services on patient outcomes.

Visual Abstract
Gender and sex differences in colorectal cancer screening, diagnosis and treatment
Authors: González-Flores Encarnación , Garcia-Carbonero Rocio , Élez Elena , Redondo-Cerezo Eduardo , Safont María José , Vera García Ruth 
Published: January 2025

Abstract
Males have a higher incidence and mortality rate from colorectal cancer (CRC) compared with females. This review examines the reasons for these differences, including risk factors, screening participation, interpretation of screening tests, presentation and tumour types, pathophysiology (particularly the impact of sex hormones on tumour-related gene expression, microsatellite instability, micro-RNA expression, and the tumour microenvironment), and the efficacy and toxicity of treatment. Sex differences in hormones and body composition are responsible for some of the sexual dimorphism in CRC incidence and outcomes, particularly the pathophysiology, CRC presentation, the pharmacokinetics of cytotoxic therapies, and the impact of treatment on outcomes. However, gender differences also play a role, affecting risk factors, access to or participation in screening and treatment, and patients’ experience of treatment (e.g. adverse events and sequelae). Sex and gender issues warrant further investigation in CRC to optimise treatment outcomes for patients.
Time to break up? The case for tailor-made digital platform regulation based on platform-governance standard types
Authors: Degen Konrad , Gleiss Alexander 
Published: January 2025

Abstract
The rise of hybrid-conglomerate platforms like Google, Apple, Microsoft, Amazon, and Meta (GAMAM) has led to significant market power concentration and negative competition implications, right down to calls for their potential breakups. To expand dominance, these platforms leverage extensive ecosystems with strategic control over resources and customer relationships, often at the expense of others. We conduct a qualitative meta-analysis of 87 empirical platform-governance problem cases from a regulatory perspective. Using a decomposition approach, we develop a taxonomy of competition problems induced by platform governance and identify four governance standard types (i.e., growth, consolidation, extension, and protect and capture), representing platform lifecycle phases from a regulatory perspective. Each standard type describes the platform owner’s governance strategy, consequent competition problems, and potential remedies. Our findings show how lack of regulation of digital platforms’ governance design has contributed to their growing market power and that effective regulatory intervention requires making platform governance more open and neutral. Moreover, we emphasize the need for platform governance regulation that shifts the burden of proof for regulatory compliance from regulators to platform owners.
Immune checkpoint inhibitor-related diabetes mellitus associated with high signal intensity in diffusion-weighted magnetic resonance imaging of the pancreas at an early clinical stage
Authors: Suzuki Masaki , Hirota Yushi , Urai Shin , Yamamoto Masaaki , Sofue Keitaro , Ogawa Wataru 
Published: January 2025

Abstract

Introduction
Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment but can give rise to immune-related adverse events such as ICI-related diabetes mellitus (DM).

Case presentation
We herein present the case of a 59-year-old Japanese man with malignant melanoma who developed ICI-related DM after 18 months of nivolumab treatment. He experienced marked hyperglycemia and diabetic ketoacidosis without a personal or family history of diabetes. Laboratory findings revealed initial preservation of insulin secretion but a rapid decline in C-peptide levels in the absence of islet autoantibodies. He was therefore diagnosed with ICI-related DM. This case fulfilled the criteria for fulminant type 1 DM but lacked the typical human leukocyte antigen alleles associated with conventional type 1 diabetes. No metastasis or morphological changes were apparent on CT scans of the pancreas, and magnetic resonance cholangiopancreatography did not show dilation or interruption of the main pancreatic duct. However, diffusion-weighted magnetic resonance imaging revealed high signal intensity with low apparent diffusion coefficient values in the pancreas, likely indicative of fibrosis or infiltration of inflammatory cells.

Discussion
This case underscores that ICI-related DM should be considered a potential immune-related adverse event as well as pointing to the benefit of diffusion-weighted imaging for assessment of pancreatic involvement at an early stage of the disease.
Antimicrobial prescribing quality in Australian emergency departments: an analysis of the Hospital NAPS data set
Authors: Zosky-Shiller Lenna , Thursky Karin , Park Sarah , James Rodney , Hall Lisa , Chen Caroline , Ierano Courtney 
Published: January 2025

Abstract

Objective:
To analyze antimicrobial prescribing practices in Australian emergency departments (ED), identifying prescribing areas requiring improvement. This aims to inform antimicrobial stewardship (AMS) strategies to enhance antimicrobial prescribing quality.

Design
Retrospective analysis of the Hospital National Antimicrobial Prescribing Survey (NAPS) data set.

Setting
EDs in public and private Australian hospitals (n = 652).

Participants
Hospitals (n = 652) that participated in the Hospital NAPS from 2013 to 2022.

Methods
Data were collected by trained auditors from participating hospitals with the use of a standardized auditing tool, the Hospital NAPS. Data from 2013 to 2022 were analyzed descriptively. Variables assessed included guideline compliance and appropriateness by antimicrobial and indication, and reasons for inappropriateness.

Results
There were 3,098 antimicrobial prescriptions from EDs included for analysis. Guideline compliance (63.5%) and appropriateness (70.4%) in EDs were lower compared to overall prescribing practices from all departments. The most commonly prescribed antimicrobial was ceftriaxone (16.9%, n = 523), and the most common indication was empiric prescribing for community-acquired pneumonia (16.0%, n = 497). Amoxicillin-clavulanic acid (53.2%, n = 99), and acute exacerbation of chronic obstructive pulmonary disease (54.3%, n = 57), were the antimicrobial and indication with the lowest rates of appropriateness respectively. Ceftriaxone prescribing also had a low rate of appropriateness (62.3%, n = 326). Selection of antimicrobials with too broad of a spectrum was the most common reason for inappropriateness (40.2%).

Conclusion
Antimicrobial prescribing quality in EDs warrants improvement. Recommended targets for AMS interventions are the excessive and inappropriate use of broad-spectrum antimicrobials such as ceftriaxone and amoxicillin-clavulanic acid in common respiratory and urinary tract infections.
Economics in a world amid flux
Authors: Boettke Peter J. 
Published: January 2025

Abstract
This essay is in celebration of the contributions of Mario Rizzo. I argue that among contemporary economists in the Austrian School of Economics tradition it is Rizzo that advanced, more than his contemporaries, the scientific research program of rational choice as if the choosers were human beings; the dynamic subjectivism and the agony of choice and social interaction; the causal processes and the institutional dynamics that make up a complex social order; and the role of law, politics and civil society in shaping commercial life. In making this argument, I attempt to arbitrage the contributions of two essays of Rizzo’s: ‘Law Amid Flux’ and ‘The Genetic-Causal Tradition and Modern Economic Theory’.