bluuebunny/crossref_metadata_2025_split huggingface dataset:
Frontal lobe epilepsy and mild malformation with oligodendroglial hyperplasia: Further observations on electroclinical and imaging phenotypes, and surgical perspectives
Authors: Garganis Kyriakos , Gkiatis Kostakis , Maletic Jelena , Harushukuri Jean , Kondylidis Nikolaos , Dinopoulos Argiris , Vorgia Pelagia , Coras Roland , Bluemcke Ingmar , Zountsas Basilios 
Published: April 2023

AbstractObjectiveMild malformation with oligodendroglial hyperplasia (MOGHE) is a recently described clinicopathologic entity, associated with drug‐resistant epilepsy and extensive epileptogenic networks. Knowledge is accumulating about particular electroclinical phenotypes, correlations with imaging, and potential prognostic significance for surgical outcomes. The study adds relevant information by documenting the presence of a hyperkinetic frontal lobe seizure phenotype in adolescents and an epileptic encephalopathy phenotype in young children.MethodsFive cases were subjected to a structured presurgical evaluation protocol, including EEG‐FMRI, chronic and acute invasive EEG, subjected to frontal lobe surgery with postoperative follow‐up between 15 months and 7 years.ResultsIn the two adult cases, surface EEG demonstrated lateralized widespread frontal lobe epileptogenicity and hyperkinetic semiological features. MRI demonstrated cortical white matter blurring and deeper white matter abnormalities. EEG‐FMRI suggested concordant frontal lobe involvement. iEEG demonstrated a widespread frontal lobe epilepsy network. The three young children demonstrated a diffuse epileptic encephalopathy phenotype, with nonlocalizing, nonlateralizing surface EEG, and “spasms” as the main seizure type. MRI demonstrated extensive frontal lobe subcortical gray and white matter abnormalities, consistent with MOGHE literature for this age, while EEG‐FMRI, in 2/3, demonstrated concordant frontal lobe involvement. They did not undergo chronic iEEG, and the resection was assisted by acute intraoperative ECoG. All cases were subjected to extensive frontal lobectomies with Engel class IA (2/5), IB (1/5), and IIB (2/5) outcomes.SignificanceThe study confirms the presence of frontal lobe epilepsy and epileptic encephalopathy phenotypes, in accordance with epilepsy phenotypes already described in MOGHE literature. Presurgical evaluation studies, including EEG‐FMRI, can provide strong lateralizing and localizing evidence of the epileptogenic networks involved. All responded favorably to extensive frontal lobe resections, despite widespread epileptic activity recorded by surface and intracranial EEG pre‐ and postoperatively; an epileptic encephalopathy phenotype, in the first years of life, should not discourage such a resection.
Phytobioactive compounds as therapeutic agents for human diseases: A review
Authors: Riaz Muhammad , Khalid Ramsha , Afzal Muhammad , Anjum Fozia , Fatima Hina , Zia Saadiya , Rasool Ghulam , Egbuna Chukwuebuka , Mtewa Andrew G. , Uche Chukwuemelie Zedech , Aslam Muhammad Aamir 
Published: April 2023

AbstractPhytobioactive compounds are plant secondary metabolites and bioactive compounds abundantly present in medicinal plants and have remarkable therapeutic potential. Oxidative stress and antibiotic resistance are major causes of present‐day ailments such as diabetes, atherosclerosis, cardiovascular disorders, cancer, and inflammation. The data for this review were collected from Google Scholar, PubMed, Directory of Open Access Journals (DOAJ), and Science Direct by using keywords: “Medicinal plants, Phytobioactive compounds, Polyphenols, Alkaloids, Carotenoids etc.” Several studies have reported the pharmacological and therapeutic potential of the phytobioactives. Polyphenols, alkaloids, terpenes, and polysaccharides isolated from medicinal plants showed remarkable antioxidant, anticancer, cytotoxic, anti‐inflammatory, cardioprotective, hepatoprotective, immunomodulatory, neuroprotective, and antidiabetic activities. This literature review was planned to provide comprehensive insight into the biopharmacological and therapeutic potential of phytobioactive compounds. The techniques used for the extraction and isolation of phytobioactive compounds, and bioassays required for their biological activities such as antioxidant, antimicrobial, anti‐inflammatory, and cytotoxic activities, have been discussed. Characterization techniques for the structural elucidation of phytobioactive compounds such as HPLC, TLC, FTIR, GC–MS/MS, and NMR have also been discussed. This review concludes that phytobioactive compounds may be used as potential alternative to synthetic compounds as therapeutic agents for the treatment of various diseases.
The effect of high‐polyphenol sumac (Rhus coriaria) on food intake using sensory and appetite analysis in younger and older adults: A randomized controlled trial
Authors: Soleymani Majd Nasim , Coe Shelly , Lightowler Helen , Thondre Pariyarath Sangeetha 
Published: April 2023

AbstractAging is accompanied by a decline in appetite and food intake with associated deficiencies in both macronutrients and micronutrients. The aim of this study was to investigate the impact of adding Iranian brown sumac (Rhus coriaria) (CIBS) into butternut squash soup on sensory evaluation and food intake among older adults (n = 20; >65 years old) and younger adults (n = 20; 18–35 years old). To evaluate the polyphenol content and antioxidant activity of the sumac samples, a Folin–Ciocalteu assay (FCR) and ferric ion reducing antioxidant power (FRAP) assay were used, respectively. L‐glutamic acid was assessed using a Megazyme L‐glutamic acid assay. Compusense software was used to assess the sensory evaluation attributes of free‐living older adults and younger adults receiving different doses of sumac in butternut squash soup. Nutritics software was used to assess food intake following the addition of 0.37 g of sumac to soup. CIBS was selected based on a preliminary assessment in vitro for L‐glutamic acid, antioxidant, and polyphenol content of six varieties of sumac. Sensory evaluation results revealed that the difference in perceived intensity of brown color between the soup samples with different doses of CIBS was greater in the younger adults' group (p = .001) than in older adults (p = .037). In addition, the food intake study found that during the ad libitum lunch, older adults consumed more energy (kcal; p = .014), protein (g; p = .025), carbohydrate (g; p = .013), and fat (g; p = .002) after soup with sumac compared to control soup. The overall findings of this study suggest that the addition of sumac to food may have a potential benefit in enhancing ad libitum lunch intake in older adults leading to effective management of malnutrition. This may promote healthy aging and minimize the burden and the consequences of anorexia of aging as main public health concerns.
The increased expression of cytokeratin 13 leads to an increase in radiosensitivity of nasopharyngeal carcinoma HNE‐3 cells by upregulating ERRFI1
Authors: Wang Huan , Shi Ming , Wan Jia , Yu Hong 
Published: April 2023

AbstractThe main factors contributing to the unfavorable outcome in the clinical treatment of patients with nasopharyngeal carcinoma (NPC) patients are radiation resistance and recurrence. This study aimed to investigate the sensitivity and molecular foundation of cytokeratin 13 (CK13) in the radiotherapy of NPC. To achieve this, a human NPC cell line overexpressing CK13, HNE‐3‐CK13, was constructed. The effects of CK13 overexpression on cell viability and apoptosis under radiotherapy conditions were evaluated using the CCK‐8 assay, immunofluorescence, and western blotting (WB). Next‐generation sequencing was performed to identify the downstream genes and signaling pathways of CK13 that mediate radiotherapy response. The potential role of the candidate gene ERRFI1 in CK13‐induced enhancement of radiosensitivity was investigated through rescue experiments using clone formation and WB. The effects of ERRFI1 on cell viability, cell apoptosis, cell cycle, and the related key genes were further evaluated using CCK‐8, immunofluorescence, flow cytometry, quantitative polymerase chain reaction and WB. The results showed that CK13 overexpression in HNE‐3 significantly inhibited cell survival under radiotherapy and promoted apoptosis marker γH2AX expression, leading to a significant increase of ERRFI1. Knockdown of ERRFI1 rescued the decreased cell viability and proliferation and the increased cell apoptosis that were caused by CK13 overexpression‐mediated radiotherapy sensitization of NPC cells. In this process, EGFR, AKT, and GSK‐3β were found involved. In the end, ERRFI1 was proven to inhibit expression levels of CDK1, CDK2, cyclin B1, and cyclin D1, resulting an increased G2/M cell ratio. Overexpression of CK13 enhances the radiosensitivity of NPC cells, which is characterized by decreased cell viability and proliferation and increased apoptosis. This regulation may affect the survival of HNE‐3 cells by increasing the expression of ERRFI1 and activating the EGFR/Akt/GSK‐3β signaling pathway, providing new potential therapeutic targets for the treatment of NPC.
Dual‐slit confocal light‐sheet microscopy using birefringent crystals
Authors: Xu Xin , Ye Hong , Wang Jixiang , Zhang Xin , Shi Guohua 
Published: April 2023

AbstractWe present a method to use a birefringent crystal for generating two illumination beams in a digital scanned laser light‐sheet microscopy (DSLM) system. Upon this, a conventional confocal DSLM can be easily upgraded to a dual‐slit confocal DSLM with two‐fold imaging speed. We have implemented this method to our bidirectional DSLM system, locating two identical calcite crystals on both illumination paths from both sides of the sample. The neurons of in vivo larval zebrafish have been fast imaged with sterling image quality, especially ~2.5 times higher contrast, compared to the conventional DSLM.
Silencing LINC00491 inhibits prostate cancer development through the miR‐384/TRIM44 axis
Authors: Zhou Songlin , Wu Cheng , Tang Qingsheng , Zhou Xunrong , He Bin , Chang Pingan , He Xiaozhou 
Published: April 2023

AbstractAccumulating evidence has demonstrated the key role of long noncoding (lnc)RNAs in tumorigenesis. Prostate cancer (PCa) is a cancer with high mortality that requires further exploration of the underlying molecular mechanisms. In the present study, we aimed to discover novel potential biomarkers for diagnosing PCa and targeting treatment. Overexpression of the lncRNA, LINC00491, was verified in PCa tumor tissues and cell lines using the real‐time polymerase chain reaction. Cell proliferation and invasion were then analyzed via the Cell Counting Kit‐8, colony formation, and transwell assays in vitro, and tumor growth in vivo. The interaction of miR‐384 with LINC00491, as well as TRIM44, was investigated via bioinformatics analyses, subcellular fractionation, luciferase reporter gene assays, radioimmunoprecipitation, pull‐down, and western blot analyses. LINC00491 was overexpressed in PCa tissues and cell lines. LINC00491 knockdown resulted in impaired cell proliferation and invasion in vitro and decreased tumor growth in vivo. Moreover, LINC00491 acted as a sponge for miR‐384 and its downstream target, TRIM44. Additionally, miR‐384 expression was downregulated in PCa tissues and cell lines, and its expression was negatively correlated with LINC00491. A miR‐384 inhibitor restored the inhibitory effects of LINC00491 silencing on PCa cell proliferation and invasion. LINC00491 is a tumor promoter in PCa via enhancing TRIM44 expression by sponging miR‐384 to facilitate the development of PCa. LINC00491 plays a significant role in PCa and could serve as both a biomarker for early diagnosis and a novel treatment target.
Novel hydrostable Z‐scheme Ag/CsPbBr3/Bi2WO6 photocatalyst for effective degradation of Rhodamine B in aqueous solution
Authors: Xue Jia‐Rong , Xue Rong‐Chao , Chen Pei‐Yao , Wang Yong , Yu Li‐Ping 
Published: April 2023

AbstractIn this study, a hydrostable Z‐scheme Ag/CsPbBr3/Bi2WO6 photocatalyst was designed and fabricated for the degradation of Rhodamine B (RhB). The structural instability of CsPbX3 perovskites in water is one of the main obstacles that restrict their practical application in photocatalytic wastewater treatment. The photocatalyst was prepared in three steps: passivation of CsPbBr3 nanocrystals (NCs) with 3‐mercaptopropionic acid (MPA), construction of a heterojunction between MPA‐passivated CsPbBr3 NCs and Bi2WO6 ultrathin nanosheets, and doping Ag nanoparticles as charge mediators in the heterojunction. The as‐obtained 5%Ag/20%CsPbBr3/Bi2WO6 exhibits good stability and excellent photocatalytic activity. The degradation rate is 93.9% in 120 min, which is 4.41 times than that of Bi2WO6.
A DFT study on the reaction mechanism of the gold(I)‐catalyzed cycloisomerization of alkynylhydroxyallylamides to 4‐Oxa‐6‐azatricyclo[3.3.0.02,8]octane and 3‐Acyl‐4‐alkenylpyrrolidine
Authors: Jung Daero , Kang Youn K. 
Published: April 2023

AbstractIn this study, we use density functional theory calculations to investigate the discrepancy between two experimental results of Au(I)‐catalyzed cycloisomerization reactions of alkynylhydroxyallyl tosylamide under similar reaction conditions, with the only variations being reaction temperature and time. The experimental results reported by Yeh and Chung groups, respectively, showed that 3‐acyl‐4‐alkenylpyrrolidines are produced dominantly at ambient temperature, while 4‐aza‐6‐oxatricyclo[3.3.0.02,8]octanes are produced in higher yield at elevated temperature. Using (Z)‐4‐([3‐phenylprop‐2‐yn‐1‐yl]amino)but‐2‐en‐1‐ol and [Au(PPh3)]+ as the model starting material and active catalyst species, respectively, we identified two major pathways leading to 4‐aza‐6‐oxatricyclo[3.3.0.02,8]octane (pathway I) and 3‐acyl‐4‐alkenylpyrrolidine (pathway II). The overall free energy barrier (ΔG‡max) and the energetic span (ΔG‡span) of each pathway were 38.3 and 48.4 kcal/mol for pathway I and 29.0 and 37.1 kcal/mol for pathway II. Our analysis shows that the disparate outcomes observed in the experiments by two separate groups mainly originate in the reaction kinetics, with both the overall activation barrier and energetic span being the important factor.
The impact of health inequities on physicians' occupational well‐being during COVID‐19: A qualitative analysis from four US cities
Authors: Browne Alyssa , Jenkins Tania , Berlinger Nancy , Buchbinder Liza , Buchbinder Mara 
Published: April 2023

AbstractObjectiveThe aim of this study is to describe frontline physicians' perceptions of the impact of racial–ethnic and socioeconomic disparities in COVID‐19 infection and mortality on their occupational well‐being.MethodsOne hundred and forty‐five qualitative, semistructured interviews were conducted between February 2021 and June 2022 with hospital medicine, emergency medicine, pulmonary/critical care, and palliative care physicians caring for hospitalized COVID‐19 patients in four US cities.ResultsPhysicians reported encountering COVID‐related health disparities and inequities at the societal, organizational, and individual levels. Encountering these inequities, in turn, contributed to stress among frontline physicians, whose concerns revealed how structural conditions both shaped COVID disparities and constrained their ability to protect populations at risk from poor outcomes. Physicians reported feeling complicit in the perpetuation of inequities or helpless to mitigate observed inequities and experienced feelings of grief, guilt, moral distress, and burnout.ConclusionsHealth inequities are an under‐acknowledged source of physicians' occupational stress that requires solutions beyond the clinical context.
Cardiac implantable electronic devices (CIEDs) and allergy
Authors: De Ruvo Ermenegildo , Petrungaro Mattia , De Luca Lucia , Bressi Edoardo , Bruni Giuseppe , Fagagnini Alessandro , Grieco Domenico , Martino Anna Maria , Panuccio Marco , Politano Alessandro , Rebecchi Marco , Calò Leonardo 
Published: April 2023

AbstractAdvances in cardiac implantable electronic devices (CIEDs) have prolonged life expectancy in various medical settings. However, the issue of hypersensitivity to components of CIEDs is still a concern. Since 1970, allergic reactions to metallic and nonmetallic components of CIEDs have been reported. Hypersensitivity reactions to medical devices are rare and not fully understood. In some cases, diagnosis and treatment are difficult. Cardiologists should always keep in mind pacemaker allergy when a patient appears with wound complications and no signs of infection. Patch testing should be tailored toward the specific biomaterials used in a device, in addition to testing with standard screening allergens in select cases.
Multicenter retrospective database evaluation of Takotsubo syndrome in subjects undergoing catheter ablation for atrial fibrillation
Authors: Sinha Neha , Tian Zizhong , Zhou Shouhao , Thomas Neal J. , Krawiec Conrad 
Published: April 2023

AbstractBackgroundIntracardiac catheter ablation for atrial fibrillation with pulmonary vein isolation may result in Takotsubo syndrome (TS), but the frequency, predisposing factors (age, sex, mental health disorders), and outcomes are currently unknown. This study sought to assess the frequency, predisposing factors, and outcomes of subjects who underwent intracardiac catheter ablation for atrial fibrillation with pulmonary vein isolation and were diagnosed with TS.MethodsThis was a retrospective observational cohort study utilizing TriNetX® electronic health record (EHR) data. We included subjects aged older than 18 years who underwent intracardiac catheter ablation for atrial fibrillation with pulmonary vein isolation. The study population was divided into two groups (no TS diagnostic code presence and TS diagnostic code presence). We analyzed the distributions of age, sex, race, diagnostic codes, common terminology procedures (CPT), and vasoactive medication codes and examined mortality rate within 30 days.ResultsWe included 69,116 subjects. Of these, 27 (0.04%) had a TS diagnostic code, the cohort was comprised mostly of females [17 (63.0%)], and 1 (3.7%) death within 30 days was reported. There were no significant differences in age and frequency of mental health disorders between those patients in TS and non‐TS cohorts. Adjusting for age, sex, race, ethnicity, patient regionality, and mental health disorder diagnostic code, those patients who developed TS had a significantly higher odds of dying in 30 days after catheter ablation compared to those without TS (OR = 15.97, 95% CI: 2.10–121.55, p = .007).ConclusionsApproximately 0.04% of subjects who underwent intracardiac catheter ablation of atrial fibrillation by pulmonary vein isolation had a subsequent diagnostic code of TS. Further study is needed to determine whether there are predisposing factors associated with the development of TS in subjects who undergo catheter ablation of atrial fibrillation by pulmonary vein isolation.
Data quality control and homogenization of daily precipitation and air temperature (mean, max and min) time series of Ukraine
Authors: Skrynyk Oleg , Sidenko Vladyslav , Aguilar Enric , Guijarro Jose , Skrynyk Olesya , Palamarchuk Liudmyla , Oshurok Dmytro , Osypov Valeriy , Osadchyi Volodymyr 
Published: April 2023

AbstractIn this paper we present the results of quality control and homogenization procedures applied to long time series of daily atmospheric precipitation sums (Rr) and daily mean (Tm), maximum (Tx) and minimum (Tn) air temperature collected in Ukraine. The daily data from 178 meteorological stations covering the period of 1946–2020 were analysed. In order to perform a thorough quality assurance check, we used the R package INQC, while the Climatol homogenization software was used to detect and remove breaks from the time series. The INQC quality assurance tests revealed a relatively small number of erroneous records (around 0.01% for each variable) and suspicious values (up to 0.09%). The application of Climatol resulted in 195, 296, 355 and 359 break points, detected for Rr, Tm, Tx and Tn, respectively. These quantities coincide roughly with the results of the HOMER homogenization procedure applied to monthly time series for the same stations and almost the same period (performed in the previous works of the authors). To verify the homogenization results, statistical comparison of the raw and homogenized time series was performed. The verification demonstrated that the quality control and homogenization procedures detected and removed errors and breaks very well, and air temperature and precipitation fields after the homogenization are more self‐consistent compared to the original raw data.
Phosphatidylglucose alleviates atherosclerosis by increasing cholesterol alienation to bile acids and cholesterol efflux in ApoE−/− mice
Authors: Yang Jin‐Yue , Zhang Tian‐Tian , Yu Zhu‐Lin , Li Xiao‐Yue , Zhao Ying‐Cai , Mao Xiang‐Zhao , Wang Yu‐Ming , Xue Chang‐Hu 
Published: April 2023

AbstractBACKGROUNDPhosphatidylcholine (PC) is considered to be the major dietary source for choline, which is associated with atherosclerosis progress. Thus, phosphatidylglucose (PG) was prepared by enzymatic modification of PC to investigate the effects on atherosclerosis in apolipoprotein E deficient (ApoE−/−) mice, as well as to investigate its dose–response relationship.RESULTSThe results showed that dietary PG significantly decreased the atherosclerotic lesion area in a dose‐dependent manner. Further studies found that intervention with a 0.8 g kg−1 and 2 g kg−1 PG diet for 4 months significantly decreased free cholesterol level and thus reduced total cholesterol levels in serum. The results of cholesterol distribution among lipoproteins showed that dietary PG significantly decreased low‐density lipoprotein levels in ApoE−/− mice. In addition, only administration of high‐dose PG significantly reduced total cholesterol levels in liver tissues by 31.2%. Furthermore, mice treated with high‐dose PG had an expanded bile acid pool and increased the ratio of conjugated bile acids to unconjugated bile acids in the liver, serum and gallbladder by increasing hepatic gene expression of primary and conjugated bile acid synthesis. Additionally, low‐dose and high‐dose PG significantly increased total fecal sterols by 20.8% and 11.9%, respectively, by increasing sitosterol and ethylcoprostanol levels.CONCLUSIONThese results indicate that PG alleviated atherosclerosis in a dose‐dependent manner by increasing cholesterol alienation to bile acids and cholesterol efflux. © 2023 Society of Chemical Industry.