bluuebunny/crossref_metadata_2025_split huggingface dataset:
Does Inferior Oblique Muscle Overaction Affect Ocular Vestibular Evoked Myogenic Potentials?
Authors: Demir İsmail , Yalcin Muhammed Zeki , Cengiz Deniz Uğur , Aydın Şükrü , Çankaya Cem , Tekin Ahmet Mahmut 
Published: May 2023

Objectives: Inferior oblique muscle overaction (IOOA) is a common ocular motility disorder. Ocular Vestibular Evoked Myogenic Potentials (oVEMP) are tests that evaluate the reflex pathway between the utricular macula and the inferior oblique muscle to detect vestibular diseases. Our study is of great importance as it is the first study in the literature to evaluate the effect of inferior oblique muscle overaction on oVEMP parameters.
Methods: Thirty-five patients with unilateral inferior oblique muscle overaction (IOOA group) and 18 healthy volunteers without any neurological or vestibulocochlear disease were included in this study. All patients and healthy volunteers were evaluated with oVEMP.
Results: No statistically significant difference was found between the n1 latency, p1 latency, n1-p1 latency measurement values of the participants included in the study (p>0,05). A statistically significant difference was found between the n1-p1 amplitude measurement values of the participants in patient groups (non-squint eyes, squint eyes) and control groups (p-value was 0.038).
Conclusion: In IOOA patients, vestibulo-ocular reflex pathway may be affected, vestibular symptoms may develop thus o-VEMP responses may be affected. A careful anamnesis should be taken in IOOA patients, and it should be kept in mind that n1-p1 amplitudes and asymmetries may be significantly higher when o-VEMP is performed
Keywords: o-VEMP, Strabismus, Inferior oblique muscle overaction, Balance, Vertigo
The Relationship between Rejection Sensitivity and Social Anxiety among College Students in Rahim Yar Khan District
Authors: Muhammad Athar Hussain  , Shanza Rafaqat  , Humza Imran  , Sehrish Hussain  
Published: May 2023

The educational study aims to find out the relationship between Rejection Sensitivity and Social Anxiety among College Students in Rahim Yar Khan District. In this research paper, challenges faced by teachers and students in finding and resolving the issues regarding social anxiety and rejection sensitivity will be discussed. The major objectives of the study were to identify the role of rejection and anxiety in academic achievement and investigate the relationship between factors influencing rejection and social anxiety among students and their effects on students’ performance. The population of the study consisted of all the girls’ and boys’ government colleges of district RYK. The total sample of the study was 500 students (180 boys and 320 girls). To achieve the objectives, two self-constructed questionnaires were used as a research tool with four Likert-type scales. The collected data were tabulated and analyzed by SPSS by using statistical measures such as percentage, frequency, mean, and std. deviation. Results declared that there is a significant and positive relationship between fear of rejection and social anxiety. A correlation test was applied to demonstrate the relationship between gender and rejection scale and its significance between factors. The main cause of anxiety is because of social setup. The addition of social exposure for students in the education period anxiety decrees and feelings of social acceptance increase. It will be helpful for the teachers to understand the social anxiety in students and tackle them according to the situation in a better way.
Faktor Pendorong Dan Pengahmbat Kampung Ramah Anak Di Kota Yogyakarta
Authors: Sugiyanto Sugiyanto , Kasmorejo Nyadi 
Published: May 2023

Anak adalah anugerah dan amanah Allah SWT kepada orang tua dan lingkungan, sehingga anak harus dijaga dan diasuh dengan sebaik-baiknya agar mereka dapat tumbuh dan berkembang dengan baik dalam lingkungan yang aman dan stabil serta suasana yang bahagia, penuh kasih saying. Disisi lain setiap anak sebagai generasi penerus bangsa dan investasi masa depan bagi negara. Atas dasar itu anak tidak saja menjadi tanggungjawab orang tua, tetapi lingkungan dan negara turut bertanggungjawab atas keselamatan setiap anak. Penelitian ini mengunakann pendekatan kualitatif eksploratif, data dikumpulkan dengan teknik observasi, interview dan studi dokumentasi. Data primer dan sekunder divalidasi serta diintegrasikan dalam konten analisis serta dianalisis dengan alat analisis SWOT. Informane ditentukan secara propursif sampling. Hasil penelitian menunjukan faktor pendorong karena kemandirian pendanaan dari warga setempat, kinerja, semangat dan komitmen pengurusyang baik serta support eksternal. Faktor penghambat tampak pada KRA kurang aktif ditandai dengan hidden action dan hidden information pengurus dan partisipasi lingkungan rendah.
Plantas acuáticas para el tratamiento de agua en espejos ornamentales
Authors: González Josefina , Santana Damarys , Quintas Patricio 
Published: May 2023

En el presente trabajo se analiza el uso de las plantas acuáticas para purificar el agua de los espejos ornamentales en el Parque de La Juventud de la Universidad deMatanzas, Cuba. El estudio se realizó a escala de laboratorio y se valoraron la determinación de parámetros como: oxígeno disuelto, demanda química y bioquímica de oxígeno, pH, dureza total, sólidos totales, coliformes fecales y cloruro. Se comprobó que las plantas acuáticas pueden disminuir los valores de los indicadores de calidad del agua a niveles que permitan disminuir la frecuencia con que se cambia el agua de los espejos. Se analizó la reutilización del agua tratada en los espejos en el riego de las plantas ornamentales del parque. Los resultados evidencian que el uso de las plantas acuáticas flotantes Nymphaea ampla y Eichornia crassipes constituye una alternativa para tratar las aguas y mejorar su calidad con un efecto económico considerable por concepto de ahorro de agua potable.
Elaboración de curvas de Intensidad Frecuencia y Duración (IFD) para la estimación de sequías en empresas agrícolas
Authors: Brown Manrique Oscar Nemesio , Gallardo Ballat Yurisbel , Pérez W 
Published: May 2023

La presente investigación analiza la elaboración de las curvas de sequía Intensidad Frecuencia Duración (IFD) en el área que comprende la Empresa de Cultivos Varios Juventud Heroica, situada en el municipio Venezuela de la provincia Ciego de Ávila, a partir del análisis de la precipitación medida en áreas de la propia empresa durante un periodo de 28 años de observaciones sistemáticas. Los resultados demuestran que se logra una adecuada estimación de la intensidad máxima de la sequía en función de la duración, a través de modelos potenciales y polinomiales de segundo y tercer orden. Las ecuaciones de Talbot proporciona una acertada relación entre la intensidad máxima y la duración de la sequía para los periodos de 2, 7, 9, 14 y 28 años; sin embargo no logran resultados confiables en los periodos de 1 y 3 años. La ecuación de Aparicio establece de forma apropiada la relación funcional instantánea entre las tres variables de severidad analizadas, con un adecuado coeficiente de correlación. En general en todos los casos evaluados se garantiza una acertada estimación y pronóstico de la intensidad máxima de sequía en la localidad de estudio.
Going for Hybrid Crops Breeding in Nepal: Strategies and Policy Dimensions
Authors: Tiwari Khusi Ram , Panthee Dilip Raj , Joshi Bal Krishna , Subedi Kalidas 
Published: May 2023

Crop Breeding programs were initiated in Nepal in 1951 with a focus on the varietal improvement of cereal crops. These varieties, however, have limited impact in the farmers' field due to their low adaptation and low yield potentials. Nepal annually imports hybrid seeds of cereals, vegetables, and flowers from India, China, and elsewhere costing billions of Rupees. It is estimated that approximately 73% of the vegetable seeds and over 60% of the hybrid seeds of maize and rice are imported annually. Hybrid seeds generally produce 20-25% more yield than conventional varieties. Despite this fact, only about 15% of maize and <10% of rice acreage in Nepal has hybrid seeds compared to over 50-60% in China. Nepal is behind in developing policies for genetic innovations, including genetics and breeding, utilizing genetic diversity, and using new biotechnological traits such as golden rice and drought tolerant wheat which could be important for Nepal in the future. Nepal has the technical knowledge, skilled human resources, and appropriate environment to produce hybrid and improved seeds of most of the crops in Nepal, but there is a lack of proper policies in place. Nepal can learn lessons from our neighboring countries, including India, China, Philippines, and Bangladesh, which are highly engaged in new technology of crop genetics, hybrid breeding, proper Plant Variety Protection (PVP) laws, and private-sector entrepreneurship. In addition, Nepal should aim to be self-sufficient and export quality hybrid seeds of cereals and vegetables that can be produced in its diverse geographies and production niches.
Liquidity Position of PT Bina Karya Jaya Abadi Tbk in Three Periods
Authors: Lau Elfreda Aplonia 
Published: May 2023

This study aims to determine and analyze the ability of PT Binakarya Jaya Abadi Tbk in fulfilling short-term obligations in three periods, namely the pre-pandemic, pandemic and after pandemic periods. The results showed that the liquidity position of PT Binakarya Jaya Abadi Tbk during the pandemic period, namely 2017, 2018 and 2019 was in a liquid state, as evidenced by the Current ratio above 200%. During the pandemic (2020 and 2021), PT Binakarya jaya Abadi Tbk’ s liquidity position was below 200%, namely in 2020 Current Ratio 117.860% and in 2021 Current ratio of 119.739%. Likewise after pandemic ,namely in 2022 the Liquidity of PT Bina karya Jaya Abadi Tbk was still below 200% even though it was better than the pandemic position. Furthermore, when measured by the Quick ratio and Cash ratio, the Liquidity position of PT. Binakarya jaya Abadi Tbk before the pandemic was below 100% and continued to decline during pandemic. Likewise during the post-pandemic period the liquidity position of PT. Binkarya jaya Abadi Tbk is in The Illiquid category. The results of this study also show that PT. Binakarya Jaya Abadi Tbk is also affected by the Corona Virus Disease 2019.
The Dual Role of ZEB2 in COAD Metastasis and Immunology
Authors: WANG Jingjing , LU Bin , ZENG Simin , LI Liqing , ZHUO Huiyan , LI Youqiang 
Published: May 2023

Objective: The zinc finger E-box binding homeobox (ZEB2), which can accelerate the nuclear DNA replication by inducing the activation of upstream transcription promoters, was widely considered as an oncogene. Recent study has found that the overexpression of ZEB2 is associated with a better prognosis in hepatocellular carcinoma. However, its roles in tumor growth, metastasis, and immunology are yet to be elucidated in COAD. Methods:	The pan-cancer sequencing data was acquired from The Cancer Genome Atlas (TCGA)-Pan cancer cohort, normal human tissue data was acquired from the Genotype-tissue expression (GTEx) database, and Broad Institute Cancer Cell Line Encyclopedia (CCLE) were downloaded from UCSC Xena. We used the cBioPortal webtool to analyze and visualize the ZEB2 pan-cancer genomic alteration rate. GEO Expression Datasets were used to explore ZEB2 expression levels in COAD patients. UCSC Xena database was used to download prognostic information of COAD patients. The Cox regression and Kaplan–Meier analyses were used to assess the prognostic role of ZEB2 in COAD. Kyoto Encyclopedia of Genes and Genomes (KEGG) was performed to determine the biological pathways. Gene Ontology (GO) enrichment analysis was performed to determine the biological processes, molecular functions, and cellular components that were altered in a ZEB2-dependent manner in COAD. The module analysis of PPI interaction network was performed using the MCODE tool of Cytoscape software, and the characteristic molecules were selected by cytohHubba tool. CIBERSORTx database was used to analyze the ZEB2 expression in the presence of 22 types of immune infiltrating cells. Results: This study found that ZEB2 was aberrantly expressed in most cancer types, and it was significantly downregulated in COAD compared with normal tissue. In addition, our findings also show that overexpression of ZEB2 was associated with a better prognosis in COAD. Mechanistic analysis revealed that overexpression of ZEB2 was associated with the neutrophil extracellular trap formation in COAD. And the results show that ZEB2 expression was significantly correlated with several kinds of immune cell infiltration. Conclusion: This study demonstrates that overexpression of ZEB2 was associated with better prognoses in patients with COAD. ZEB2 has close relationship with ACTB, which was highly related to NETs. These findings suggest a dual role of ZEB2 in COAD growth, metastasis, and immunology.
Nature‐Inspired Stalactite Nanopores for Biosensing and Energy Harvesting
Authors: Chernev Andrey , Teng Yunfei , Thakur Mukeshchand , Boureau Victor , Navratilova Lucie , Cai Nianduo , Chen Tzu‐Heng , Wen Liping , Artemov Vasily , Radenovic Aleksandra 
Published: May 2023

AbstractNature provides a wide range of self‐assembled structures from the nanoscale to the macroscale. Under the right thermodynamic conditions and with the appropriate material supply, structures like stalactites, icicles, and corals can grow. However, the natural growth process is time‐consuming. This work demonstrates a fast, nature‐inspired method for growing stalactite nanopores using heterogeneous atomic deposition of hafnium dioxide at the orifice of templated silicon nitride apertures. The stalactite nanostructures combine the benefits of reduced sensing region typically for 2‐dimensional material nanopores with the asymmetric geometry of capillaries, resulting in ionic selectivity, stability, and scalability. The proposed growing method provides an adaptable nanopore platform for basic and applied nanofluidic research, including biosensing, energy science, and filtration technologies.
NHPI/O2‐Mediated Electrochemical Intermolecular Cyclization/Dehydrogenation for the Construction of Polycyclic Quinazolinones
Authors: Liu Lei , Xu Zhenhui , Lin Jie , Zhang Zhensheng , Wu Yongzhen , Yang Pengtao , Hang Yunfei , Song Dingguo , Zhong Weihui , Ling Fei 
Published: May 2023

AbstractHerein, an eco‐friendly and atom‐economical electrochemical methodology with isatins and 1,2,3,4‐tetrahydroisoquinolines through NHPI/O2‐mediated intermolecular oxidation/annulation is disclosed, leading to a variety of polycyclic quinazolinones in 46–82% yields. This oxidative cyclization proceeded in transition metal‐ and strong oxidant‐free conditions and generated H2 and CO2 as byproducts. Additionally, late‐stage functionalization and broad substrate scope demonstrated the synthetic usefulness of this protocol.
PCSK9 Inhibitors as Adjunctive Therapies in Hypercholesterolemia: Benefits, Limitations, and Possible Alternatives
Authors: Hamad Mawieh , Muhammad Jibran Sualeh , Rah Bilal , Hasan Haydar , Taneera Jalal , Soofi Abdulsalam , Awadallah Samir 
Published: May 2023

AbstractThe clinical application of statins as anti‐hypercholesterolemia medications, while very beneficial, remains limited by intolerance and side effects. Statins increase the production of proprotein convertase subtilisin/kexin type 9 (PCSK9), which degrades low‐density lipoprotein (LDL) receptor and limits circulating LDL cholesterol (LDLC) uptake. PCSK9 also promotes cardiomyocyte and vascular smooth muscle cell apoptosis and vascular injury. Several PCSK9 inhibitors (evolocumab, alirocumab, and inclisiran) are highly effective at reducing plasma LDLC levels and moderately effective at protecting against cardiovascular disease. However, their long‐term use needs to take the following issues into account: i) PCSK9 deficiency leads to various pathologies like heart failure and liver steatosis, ii) PCSK9 regulates lipid homeostasis, iii) depletion of circulating PCSK9 may itself upregulate PCSK9 expression, and iv) the cost of available inhibitors is beyond the reach of most people. Therefore, the long‐term safety and affordability of PCSK9 inhibitors needs to be revisited and additional therapeutic options need to be explored.
Model predictive in vitro dissolution testing in pharmaceutical continuous manufacturing: An equivalence study
Authors: Su Qinglin , Hermant Paul , Casati Federica , Halkude Bhakti , Wu Wei , Ramnath Anjana , Dubey Atul , Born Stephen , Takizawa Bayan , Mascia Salvatore 
Published: May 2023

AbstractA predictive mathematical model for tablet dissolution was developed and implemented in an end‐to‐end integrated continuous manufacturing pilot plant. The tablets were produced for immediate release with a proprietary extrusion‐molding‐coating (EMC) unit operation. Besides the mass balance of API solute in the buffer solution, the model consisted of the dissolution, diffusion, and population balance of API particles in the swollen tablet, which was mainly controlled by the swelling and erosion of the polymeric excipient matrix. An equivalence study was investigated by comparing the model prediction to the experiments that were conducted according to USP42‐NF37 General Chapter <711> Dissolution, during which the drug dose level was varied in a range from 60 to 80 wt%. Consistent equivalence was demonstrated with the similarity factor f2 > 50 for all sampled tablets. Concluding remarks and industrial perspectives on model predictive in vitro dissolution testing are provided.
Antisense Oligonucleotide Silencing Reverses Abnormal Neurochemistry in Spinocerebellar Ataxia 3 Mice
Authors: McLoughlin Hayley S. , Gundry Katherine , Rainwater Orion , Schuster Kristen H. , Wellik Isabel G. , Zalon Annie J. , Benneyworth Michael A. , Eberly Lynn E. , Öz Gülin 
Published: May 2023

ObjectiveSpinocerebellar ataxia type 3 (SCA3) is the most common dominantly inherited ataxia, and biomarkers are needed to noninvasively monitor disease progression and treatment response. Anti‐ATXN3 antisense oligonucleotide (ASO) treatment has been shown to mitigate neuropathology and rescue motor phenotypes in SCA3 mice. Here, we investigated whether repeated ASO administration reverses brainstem and cerebellar neurochemical abnormalities by magnetic resonance spectroscopy (MRS).MethodsSymptomatic SCA3 mice received intracerebroventricular treatment of ASO or vehicle and were compared to wild‐type vehicle‐treated littermates. To quantify neurochemical changes in treated mice, longitudinal 9.4T MRS of cerebellum and brainstem was performed. Acquired magnetic resonance (MR) group means were analyzed by 2‐way analysis of variance mixed‐effects sex‐adjusted analysis with post hoc Sidak correlation for multiple comparisons. Pearson correlations were used to relate SCA3 pathology and behavior.ResultsMR spectra yielded 15 to 16 neurochemical concentrations in the cerebellum and brainstem. ASO treatment in SCA3 mice resulted in significant total choline rescue and partial reversals of taurine, glutamine, and total N‐acetylaspartate across both regions. Some ASO‐rescued neurochemicals correlated with reduction in diseased protein and nuclear ATXN3 accumulation. ASO‐corrected motor activity correlated with total choline and total N‐acetylaspartate levels early in disease.InterpretationSCA3 mouse cerebellar and brainstem neurochemical trends parallel those in patients with SCA3. Decreased total choline may reflect oligodendrocyte abnormalities, decreased total N‐acetylaspartate highlights neuronal health disturbances, and high glutamine may indicate gliosis. ASO treatment fully or partially reversed select neurochemical abnormalities in SCA3 mice, indicating the potential for these measures to serve as noninvasive treatment biomarkers in future SCA3 gene silencing trials. ANN NEUROL 2023;94:658–671
Purely Organic Fluorescence Afterglow: Visible‐Light‐Excitation, Inherent Mechanism, Tunable Color, and Practical Applications with Very Low Cost
Authors: Wang Jiaqiang , Yang Yujie , Li Kexin , Zhang Liyao , Li Zhen 
Published: May 2023

AbstractPurely organic materials with visible light excitable fluorescence afterglow are promising for applications. Herein, fluorescence afterglow with various intensity and duration was observed on fluorescent dyes once being dispersed in polymer matrix, thanks to the slow reverse intersystem crossing rate (kRISC) and long delayed fluorescence lifetime (τDF) derived from the coplanar and rigid chemical structure of the dyes. To verify the mechanism, different polymers were used to tune singlet‐triplet splitting energy based on solvent effect. And commercial acriflavine (Acf) film showed blue shifted fluorescence compared to purified one, with slower kRISC (≈100 s−1) and longer τDF (0.6 s). Via energy transfer from Acf to rhodamine B, the afterglow color was further regulated, with the largest fluorescence quantum yield of 42.4 %. It was demonstrated that the materials worked on color tunable light sources, and low‐cost ($2 for 50 000 labels) anti‐counterfeit labels recognized by white light.
Side‐Chain Molecular Engineering of Triazole‐Based Donor‐Acceptor Polymeric Photocatalysts with Strong Electron Push‐Pull Interactions
Authors: Luo Zhipeng , Chen Xiaowen , Hu Yuanyuan , Chen Xiong , Lin Wei , Wu Xiaofeng , Wang Xinchen 
Published: May 2023

AbstractA new series of donor‐acceptor (D‐A)‐type semiconductive polymers were generated by the integration of electron‐deficient alkyl chain anchored triazole (TA) moieties and electron‐rich pyrene units into the polymer skeleton. The polymer series demonstrated satisfactory light‐harvesting ability and suitable band gaps. In the series, polymer P‐TAME benefits from a minimized exciton binding energy, strongest D‐A interaction, and favorable hydrophilicity, affording an outstanding photocatalytic H2 evolution rate of ca. 100 μmol h−1 (10 mg polymer, AQY420 nm=8.9 %) and H2O2 production rate of ca. 190 μmol h−1 (20 mg polymer) under visible‐light irradiation, which is superior to most currently reported polymers. All polymers in the series can mediate water oxidation reactions to evolve O2. Thus, these TA‐based polymers open up a new avenue toward tailor‐made efficient photocatalysts with broad photocatalytic activities.
Magnesium(I) Reduction of Aluminum(III) Hydride Complexes: Generation of Mixed Valence Aluminum (AlI/Al0) Hydride Cluster Compounds, [Al6H8(NR3)2{Mg(β‐diketiminate)}4]**
Authors: Mullassery Sneha , Yuvaraj K. , Dange Deepak , Jones Dafydd D. L. , del Rosal Iker , Piltz Ross O. , Edwards Alison J. , Maron Laurent , Jones Cameron 
Published: May 2023

AbstractReduction of a range of amido‐ and aryloxy‐aluminum dihydride complexes, e.g. [AlH2(NR3){N(SiMe3)2}] (NR3=NMe3 or N‐methylpiperidine (NMP)), with β‐diketiminato dimagnesium(I) reagents, [{(ArNacnac)Mg}2] (ArNacnac=[HC(MeCNAr)2]−, Ar=mesityl (Mes) or 2,6‐xylyl (Xyl)), have afforded deep red mixed valence aluminum hydride cluster compounds, [Al6H8(NR3)2{Mg(ArNacnac)}4], which have an average Al oxidation state of +0.66, the lowest for any well‐defined aluminum hydride compound. In the solid‐state, the clusters are shown to have distorted octahedral Al6 cores, having zero‐valent Al axial sites and mono‐valent AlH2− equatorial units. Several novel by‐products were isolated from the reactions that gave the clusters, including the Mg−Al bonded magnesio‐aluminate complexes, [(ArNacnac)(Me3N)Mg−Al(μ‐H)3[{Mg(ArNacnac)}2(μ‐H)]]. Computational analyses of one aluminum hydride cluster revealed its Al6 core to be electronically delocalized, and to possess one unoccupied, and six occupied, skeletal molecular orbitals.