bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of succinates on the inflammatory response: a review
Authors: Lazarev Vladimir V. , Anchutin P. E. 
Published: September 2023

INTRODUCTION: Endogenous succinate functions as a pro-inflammatory factor, while exogenous succinate — as an anti-inflammatory factor. The mechanisms of effect of succinates on the inflammatory response are not fully understood. OBJECTIVE: Generalization of the current scientific knowledge on the use of exogenous succinate in inhibition of the inflammatory response. MATERIALS AND METHODS: The PubMed, Web of Science, Google Scholar, Scopus, and eLibrary international databases were used to search for relevant articles. The search keywords were: “succinic acid”, “amber acid”, “inflammation”, “meglumine sodium/solution”. The search was limited to articles published between 2012 and December 2022. The inclusion criteria were: 1) research focused on the cellular energy supply in inflammation; 2) effects of succinate on the inflammatory response intensity due to changes in the cellular energy supply; 3) correlation of the cellular energy supply with clinical and laboratory inflammatory indicators when succinate-containing drugs are used; 4) original studies. RESULTS: The initial identification analysis included over 200 published studies. After the screening, 84 full-text articles meeting the selection criteria were included in the final review: 31 literature reviews, 24 of which are dedicated to the pro-inflammatory effects of endogenous succinate, and 7 — to the anti-inflammatory effect of exogenous succinate in succinate-containing agents; and 53 original scientific articles: 27 articles are dedicated to the research of molecular mechanisms of endogenous succinate, and 26 articles are dedicated to the study of the clinical use of succinate-containing drugs. CONCLUSIONS: Endogenous succinate is defined as the most important pro-inflammatory factor. Exogenous succinate has a pronounced anti-inflammatory effect mediated by normalization of the immune cell energy supply in hypoxia. No studies have been found on the differences in the mechanism of action of endogenous and exogenous succinate.
Impact of multizonal decontamination of upper respiratory tract on incidence of ventilator-associated pneumonia: multicenter randomized pilot study
Authors: Lapin К. S. , Fot Е. V. , Kuzkov Vsevolod V. , Кirov М. Yu. 
Published: September 2023

INTRODUCTION: Ventilator-associated pneumonia (VAP) is the one of nosocomial infections in intensive care units. VAP can result in prolonged duration of hospitalization and invasive mechanical ventilation (MV) that is associated with attributive mortality. OBJECTIVE: The aim of our pilot multicenter randomized study was to assess effect of the multizonal decontamination of upper airway including subglottic space on the VAP incidence and time of onset, as well as colonization upper airway and clinical outcomes. MATERIALS AND METHODS: Sixty patients requiring the prolonged MV were included in the prospective study. All participants were randomized into three groups: the control, the local antiseptic (LA) and the bacteriophage (BP). All patients were managed using similar VAP protective bundle. Infection-related ventilator-associated complications (IVAC) were registered based on clinical, laboratory, and instrumental examination. Diagnosis of VAP was confirmed if CPIS was ≥ 6 points. RESULTS: A total incidence of IVAC did nоt differ between groups: 15 (75 %), 14 (70 %), and 17 (85 %) cases in the control, LA, and BP groups, respectively. The VAP incidence was lower in the LA and BP groups compared with the controls: 3 (15 %) and 3 (15 %) vs 10 (50 %) cases (χ2 = 8.35; p = 0.015). The overall mortality was 30 % and did not differ between the groups. Multi-selective decontamination resulted in a trend to increased ventilator-associated tracheobronchitis incidence in the BP group and to silent colonization in both LA and BP groups (p = 0.07). No differences in the duration of MV, ICU and hospital stay were observed. CONCLUSIONS: The combined multizonal upper airway decontamination involving subglottic space is associated with a reduction of the VAP incidence but did not change the overall IVAC rate. Multizonal decontamination based on subglottic bacteriophage instillation might have a potential to influence the microbial heterogeneity of upper airways.
Permanensi Kawasan Masjid Raya Sabilal Muhtadin Banjarmasin
Authors: Alison Daniel , Sunaryo Rony Gunawan , Damayanti Rully 
Published: September 2023

Title: The Permanence of Sabilal Muhtadin Great Mosque Area

The area of the Great Mosque of Sabilal Muhtadin Banjarmasin was originally the location of "Fort Van Tatas," namely the fortress of Tatas Island in the Dutch East Indies era. This area is the first layer of the development of Banjarmasin City, starting with the Tatas Fortress with a defense function. In its development, the area underwent several changes in function and form until the era of the Republic of Indonesia. In this area, the Great Mosque of Sabilal Muhtadin was established as an Islamic religious center in Banjarmasin. Given the significance of the area as the first layer of the city, the research aims to provide an overview of the morphology of the Sabilal Region from time to time. Next, use the city morphology approach to identify the permanence of the elements forming the area, including what elements remain, the elements that change, and the elements that are missing. Synchronic and diachronic analysis methods are carried out on urban tissue areas, including observed elements: roads, open spaces, natural elements and plots-blocks, and buildings. The analysis results show that the area's morphology has changed the urban tissue character of the area from a center of defense to a center of religion. In comparison, some of the area's elements have changed and disappeared, such as elements of the fort and elements of roads, and rivers.
Analysis of physical and non-physical factors associated with individual water consumption using a hierarchical linear model before and after an earthquake in a region with insufficient water supply
Authors: Ito Yuri , Yokomichi Hiroshi , Shrestha Sadhana , Kiem Anthony S. , Kondo Naoki , Nishida Kei 
Published: September 2023

Abstract
In regions suffering from water scarcity, residents commonly employ several coping strategies such as the use of multiple water sources, water storage and water sharing and borrowing. This study applies a hierarchical linear regression model to investigate the physical (i.e. water source and supply time) and non-physical (i.e. number of families, wealth status, education for household head, house ownership, water treatment and community involvement) factors associated with individual water consumption throughout the Kathmandu Valley, Nepal. During the baseline period (dry season before the 2015 Gorkha earthquake), the average water consumption was 91 litre/capita/day (LPCD) but there was a regional disparity in water consumption, ranging from 16 to 158 LPCD. The statistical analysis indicated that households using many water sources consumed more water regardless of the supply area even in an emergency. In addition, households with many family members used less water per person. During emergencies, households participating in the local community were found to consume more water than households not participating in the community, especially when the water being used was managed by the community.
Water, sanitation, and hygiene facilities: enabling or impeding handwashing? An assessment of a primary school infrastructure in Palwal, India
Authors: Gupta Vibha , Anand Sarita 
Published: September 2023

AbstractThe importance of water, sanitation, and hygiene (WASH) facilities in school cannot be ignored in protecting children from communicable diseases. However, reports from UNICEF suggest that there is a lack of adequate WASH facilities and a dearth of adequate data on available facilities, particularly from developing countries. The present study sought to address this gap and build on the evidence-base of school hygiene and sanitation facilities in rural India. The study also assessed the association between available facilities and the handwashing behavior of students. Data were collected from 28 schools using a modified Joint Monitoring Program (JMP) observation checklist and a self-administered questionnaire. Results indicate a universal coverage of WASH facilities in the sampled schools, though the sufficiency and usability of the infrastructure were inadequate. The study also found better hand hygiene KAP scores among students in schools that had handwashing stations closer to toilets (p = 0.018). We conclude that while India has improved access to facilities under the recent National policy push, there needs to be a continued focus on increasing sufficiency, maintenance and usability of the facilities. Additionally, health promotion activities that include teachers, parents and the community are required to improve the hygiene and sanitation behavior of school children.
Effective management of the watershed in response to historical climate change using a GIS-based multi-criteria decision analysis (MCDA)
Authors: Arshed Abu Bakar , Masood Mohammad , Zafar Muhammad Awais , Nabi Ghulam , Iqbal Mudassar 
Published: September 2023

Abstract

Watershed management is necessary to conserve water resources because the watershed hydrological processes are more affected by climate and land use change, resulting in the problems of droughts, floods, soil erosion, etc. This study determined suitable alternatives that can ensure viable strategies for tackling the climate change impacts at the Soan River Basin (SRB). A framework was applied to assess the impacts of climate change and land use/cover change (LUCC) using the Soil and Water Assessment Tool (SWAT). A multi-criteria decision analysis (MCDA) was used to prioritize watershed management alternatives by comparing watershed management criteria and alternatives using the analytic hierarchy process (AHP). Framework findings showed a 69 and 31% decline in runoff, and a 58 and 42% increment in evapotranspiration (ET) due to climate change and LUCC, respectively. The top prioritized suitable alternatives were water harvesting structure (WHS) and vegetative cover (VC). Suitability analysis showed that 63.61 and 16.56% area of the SRB were moderately to highly suitable for WHS, respectively. For soil and water management, VC has been found suitable to moderately suitable for 72.68 and 26.75% of the basin area, respectively. So, there should be adoption of such measures which will assist in configuring the climate adaptive strategies.
Does Bi-exponential Fitting Perform better than Mono-exponential Fitting in
IVIM-DWI? An Assessment of Renal Pathological Injury of IgA Nephropathy
Authors: Mao Wei , Ding Xiaoqiang , Ding Yuqin , Fu Caixia , Zeng Mengsu , Zhou Jianjun 
Published: September 2023

Background:
Chronic kidney disease has become one of the world's major public health problems, immunoglobulin A (IgA) nephropathy is a common pathological type of CKD. Delaying the progression of IgA nephropathy has currently become the main clinical treatment strategy, precise evaluation of renal pathological injury during follow-up of patients with IgA nephropathy is important. Therefore, it is imperative to develop an accurate and non-invasive imaging technique for effective follow-up of renal pathological injury in patients with IgA nephropathy.

Objective:
To investigate the clinical value of intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI) in assessing renal pathological injury in patients with immunoglobulin A (IgA) nephropathy compared with a mono-exponential model.

Methods:
Altogether, 80 patients with IgA nephropathy were divided into the mild (41 cases) andmoderate–severe (m–s) renal injury groups (39 cases) according to pathology scores, and 20 healthy volunteers were recruited as controls. All participants underwent IVIM-DWI of the kidneys, and renal parenchymal apparent diffusion coefficient (ADC), pure molecular diffusion coefficient (D), pseudo-diffusion coefficient (D*), and perfusion fraction (f) values were measured. One-way analysis of variance, receiver operating characteristic (ROC) curve analysis, and Pearson correlation analysis were performed for all the DWI-derived parameters.

Results:
The DWI-derived parameters of the m–s renal injury group were significantly lower than those of the mild renal injury and control groups (P < 0.01). The ROC analysis revealed that f had the largest area under the ROC curve for differentiation between the m–s and mild renal injury groups and between the m–s renal injury and control groups. The f had the largest correlation coefficient with renal pathology scores (r=−0.81), followed by the D* (−0.69), ADC (−0.54), and D values (−0.53), respectively (all P<0.01).

Conclusion:
IVIM-DWI demonstrated better diagnostic performance than the mono-exponential model in assessing renal pathological injury in patients with IgA nephropathy.
Firearm Possession Rates in Home Countries and Firearm Suicide Rates Among US- and Foreign-Born Suicide Decedents in the United States: Analysis of Combined Data from the National Violent Death Reporting System and the Small Arms Survey
Authors: Song In Han , Lee Jin Hyuk , Shin Jee Soo 
Published: September 2023

Background
Suicide by firearms is a serious public health issue in the United States. However, little research has been conducted on the relationship between cultural backgrounds and suicide by firearms, specifically in those born and raised in the United States compared to those who have immigrated to the United States.

Objective
To better understand the relationship between cultural backgrounds and suicide, this study aimed to examine firearm suicide rates among US- and foreign-born suicide decedents based on the firearm possession rate in the decedent’s home country.

Methods
Multivariate logistic regression was performed to analyze data of 28,895 suicide decedents from 37 states obtained from the 2017 National Violent Death Reporting System data set. The firearm possession rate in the home countries of foreign-born suicide decedents was obtained from the 2017 Small Arms Survey.

Results
The firearm suicide rate was about twice as high among US-born suicide decedents compared to their foreign-born counterparts. Meanwhile, suicide by hanging was about 75% higher among foreign-born compared to US-born suicide decedents. Those from countries with a low-to-medium firearm possession rate were significantly less likely to use firearms compared to US-born suicide decedents (adjusted odds ratio [AOR]=0.45, 95% CI 0.31-0.65, and AOR=0.46, 95% CI 0.39-0.53, respectively). Meanwhile, firearm suicide rates were not different between US- and foreign-born suicide decedents from countries with a similarly high firearm possession rate.

Conclusions
The results suggest that there is an association between using firearms as a means of suicide and the firearm possession rate in the decedent’s home country. Suicide by firearms in the United States needs to be understood in the sociocultural context related to firearm possession.
Siklus Hidup Destinasi Wisata di Kabupaten Pangandaran
Authors: Juhara Latifah Nurrahmah , Marsoyo Agam 
Published: September 2023

Studi pariwisata sering menilai pengembangan tujuan wisata berdasarkan siklus hidup teori siklus hidup.Berdasarkan enam tahap teori siklus hidup pariwisata,penelitian ini bertujuan untukmengidentifikasiposisi destinasi wisata destinasi wisata di Kabupaten Pangandaran dalam siklus hidup pariwisata. siklus hidup pariwisata. Berfokus pada dua puluh enam destinasi wisata yang wisata terkemuka di Kabupaten Pangandaran, penelitian ini berusaha menyediakan data substansial untuk mengevaluasi pertumbuhan dari destinasi wisata tersebut. Metode analisis yang digunakan dalam studi ini menggunakan analisis Multidimensional Scaling (MDS),yang kemudian didukung dengan analisis deskriptif kualitatif. deskriptif kualitatif. Hasil penelitian ini menemukan bahwa destinasi wisata wisata di Kabupaten Pangandaran secara umum berada dalam empat tahapan dalam siklus hidup kawasan pariwisata. Terdapat tiga destinasi wisatayang dinyatakan dalam tahap konsolidasi, tiga destinasi wisata yang dinyatakan dalam tahap pengembangan pengembangan, dua belas destinasi wisata pada tahap pelibatan tahap keterlibatan, dan delapan destinasi wisata pada tahap awal yaitu eksplorasi. Destinasi wisata yang berada pada tahap tahap pertama yaitu tahap eksplorasi. Dalam tahap ini destinasi wisata tersebut memiliki daya tarik alam dan dikelola secara tidak terorganisir dan juga belum ada penyediaan penyediaan sarana dan prasarana pendukung. Berbeda halnya dengan destinasiwisata pada tahap keterlibatan yang ditandai dengan keterlibatan masyarakat dalam pengelolaan destinasi wisata. pengelolaan destinasi wisata. Destinasi wisata yang berada pada tahap pengembangan sedang dalam proses pengembangan yang intensif.
Место встречи и пространство обмена: роль постсоветского рынка в жизни городского сообщества (на примере г. Элисты)
Authors:   Kalmyk Scientific Center of the RAS (8, Ilishkin St., 358000 Elista, Russian Federation), Lidzhieva Altana M. 
Published: September 2023

Introduction. The article discusses the place, functions and significance of marketplaces in urban space. Goals. So, the paper particularly aims to consider the place, functions and significance of the marketplace in the public space of Elista. Materials. The study employs the structural-functional method and that of participant observation. Results. The Central Cossack Bazaar is an important resource for the shaping of Elista’s market economy — small and medium-sized businesses. The marketplace has changed essentially through the stages of its existence within boundaries of the urban landscape, and would prove a most suitable place for trade and supply of the population in certain historical periods. Its place in public life formed the function of a common territory and shaped the structure of traffic flows.
Understanding the Sustainability Reporting Landscape and Research Opportunities in Accounting
Authors: Dechow Patricia M. 
Published: September 2023

ABSTRACT
I first distinguish the terms economic growth, economic development, and sustainable development. I then discuss the term ESG and why this term is used with respect to the corporation. I follow with a discussion of the shareholder primacy perspective and how this perspective plays a defining role in corporate law, corporate governance, and asset management. I argue that the shareholder primacy perspective is not appropriate for sustainability reporting because when a firm pollutes the environment, reduces biodiversity, or has inequitable social policies, it does not bear the full cost of its action; society and the planet does. Therefore, providing sustainability disclosures that are relevant to investors misses the point that sustainability disclosures are motivated by the desire of other stakeholders to learn about externalities. I discuss the different standard setters in the sustainability space and how accounting and measurement play key roles. I close with a discussion of research opportunities.
Data Availability: Data are publicly available from sources indicated in the text.
JEL Classifications: K22; L21; M41; M48; Q56; Q58.
Analisis Hidrogeokimia dan Fasies Airtanah di Kabupaten Rembang
Authors: Widyastuti Santhi , Triadi Putranto Thomas 
Published: September 2023

Air merupakan salah satu komponen yang harus terpenuhi bagi kelangsungan makhluk hidup. Airtanah merupakan bagian dari sumberdaya air yang baik untuk minum maupun kebutuhan air bersih lainnya. Berkaitan dengan masalah tersebut, maka tujuan dilakukannya penelitian ini yaitu untuk mengetahui potensi airtanah yang layak digunakan sebagai air minum berdasarkan kandungan hidrogeokimianya. Metode yang digunakan yaitu metode pengambilan sampel sebanyak 108 sampel airtanah untuk data MAT dan 30 sampel airtanah yang dianalisis dengan metode Water Quality Index (WQI). Berdasarkan hasil penelitian menunjukkan bahwa sifat kimia pada akuifer bebas, memiliki kesadahan paling tinggi yaitu 1466 mg/L, daya hantar listrik paling tinggi yaitu 7290 µS/cm, jumlah garam terlarut paling tinggi yaitu 4860 mg/L dan pH berkisar 7 hingga 7,9. Dengan menggunakan tabel kurlov tipe airtanah yang paling mendominasi yaitu Ca²⁺-HCO3⁻. Berdasarkan diagram piper termasuk kedalam Fasies alkali tanah dominan hidrogen karbonat, Fasies campuran dominan hidrogen karbonat, dan Fasies alkali dominan klorida. Terdapat 1 sampel tidak layak minum di Kecamatan Rembang, 4 sampel berkualitas buruk dan 15 sampel memiliki kualitas baik hingga sangat baik yang tersebar di Kecamatan Gunem dan Kecamatan Bulu.
Effect of Low Fat and Low Cholesterol Diet Intervention on LDL Subgroups in Dyslipidemic Patients: Epidemiological Observational Study
Authors: KAÇAR MUTLUTÜRK Ülger , ÇİÇEK Betül , BAYRAM Fahri , DOĞRUEL Fatma 
Published: September 2023

Aim: According to studies, the individual cardiovascular disease (CVD) risk is predicted and low density lipoprotein cholesterol (LDL
cholesterol) sub-group concentration better than LDL cholesterol. High fat and cholesterol intakes are generally considered to pose a risk
on CVD. The purpose of this study is to analogize LDL sub-group concentration pre and post a diet with LowFat and LowCholesterol
written a prescription to dyslipidemic sicks along 3 months.
Material and Methods: Diagnosticated dyslipidemia sicks (n=47) on the part of the endocrinologist were pursued along 3 months
via a LowFat, LowCholesterol diet upon a lasting a month basis, on condition that they were proper for each. Before and after dietary
intervention periods, biochemical parameters and anthropometric measurements were compared.
Results: A sum of 47 participants (15 men and 32 women) with an average age of 48.51±9.86 years were involved. 13 women were at
premenopausal and 19 women were at postmenopausal stages of 32 women involved. Small dense LDL (Sd-LDL) decreased from 11.0
(0.0-37.0) mg/dL at the beginning to 7.0 (0.0-68.1) mg/dL after the dietary intervention, but this decline was unimportant (p=0.686).
Midbands (MiDC, MidB, MidA) subgroups of intermediate density lipoprotein cholesterol (IDL-cholesterol) declined considerably after
dietary interference (p
COVID-19 Karantina Sürecinin Diyabetik Makula Ödemi Tedavisine Etkileri
Authors: BİLİCİ Serdar , SELÇUK Neriman , GÜLTEKİN-EROL Tuba , UĞURBAŞ Suat Hayri 
Published: September 2023

Amaç: COVID-19 pandemisi nedeniyle tedaviye verilen aranın diyabetik maküla ödemi (DMÖ) olgularındaki anatomik ve fonksiyonel
etkilerinin değerlendirilmesi amaçlanmıştır.
Gereç ve Yöntemler: COVID-19 nedeniyle anti-vasküler büyüme faktörü (VEGF) tedavisine ara verilen DMÖ olguları çalışmaya dahil
edildi. Olguların yaş, cinsiyet, tedaviye verilen ara süresi ve tekrar tedavi sonrası enjeksiyon sayısı ile takip süresi kaydedildi. Karantina
öncesi son vizitleri (V0), karantina sonrası ilk (V1) ve son vizitlerindeki (V2) görme keskinlikleri (GK) ve optik koherans tomografi
ile santral makula kalınlığı (SMK) değerlendirildi. Olgular tedaviye verilen ara süresine göre 18 hafta ve altı (Grup-1) ile 18 hafta üzeri
(Grup-2) olarak alt gruplara ayrıldı ve analiz edildi.
Bulgular: Çalışmaya yaş ortalaması 63,1 yıl (42-80 yıl arası) olan 89 olgunun 89 gözü dahil edildi. Pandemi sürecinde tedaviye verilen
ara ortalaması 21,03 hafta (12-48 hafta) olarak saptandı. Tekrar tedaviye başlanan olguların ortalama takip süresi 31,2 hafta (8 - 52 hafta)
olup bu süreç içerisinde ortalama 2,98 (1-8) anti-VEGF tedavi uygulanmıştı. Tüm grupta V0, V1 ve V2 vizitlerindeki ortalama GK
sırasıyla 0,64, 0,64 ve 0,63 LogMAR (p=0,168), ortalama SMK değerleri sırasıyla 383,06, 434,82 ve 373,27 mikron (p