bluuebunny/crossref_metadata_2025_split huggingface dataset:
Constructive Consumer Choice Processes
Authors: Bettman James R. , Luce Mary Frances , Payne John W. 
Published: July 2002

Abstract
Consumer decision making has been a focal interest in consumer research, and consideration of current marketplace trends (e.g., technological change, an information explosion) indicates that this topic will continue to be critically important. We argue that consumer choice is inherently constructive. Due to limited processing capacity, consumers often do not have well-defined existing preferences, but construct them using a variety of strategies contingent on task demands. After describing constructive choice, consumer decision tasks, and decision strategies, we provide an integrative framework for understanding constructive choice, review evidence for constructive consumer choice in light of that framework, and identify knowledge gaps that suggest opportunities for additional research.
GeneCards: a novel functional genomics compendium with automated data mining and query reformulation support.
Authors: Rebhan M , Chalifa-Caspi V , Prilusky J , Lancet D 
Published: July 2002

Abstract
MOTIVATION: Modern biology is shifting from the 'one gene one postdoc' approach to genomic analyses that include the simultaneous monitoring of thousands of genes. The importance of efficient access to concise and integrated biomedical information to support data analysis and decision making is therefore increasing rapidly, in both academic and industrial research. However, knowledge discovery in the widely scattered resources relevant for biomedical research is often a cumbersome and non-trivial task, one that requires a significant amount of training and effort. RESULTS: To develop a model for a new type of topic-specific overview resource that provides efficient access to distributed information, we designed a database called 'GeneCards'. It is a freely accessible Web resource that offers one hypertext 'card' for each of the more than 7000 human genes that currently have an approved gene symbol published by the HUGO/GDB nomenclature committee. The presented information aims at giving immediate insight into current knowledge about the respective gene, including a focus on its functions in health and disease. It is compiled by Perl scripts that automatically extract relevant information from several databases, including SWISS-PROT, OMIM, Genatlas and GDB. Analyses of the interactions of users with the Web interface of GeneCards triggered development of easy-to-scan displays optimized for human browsing. Also, we developed algorithms that offer 'ready-to-click' query reformulation support, to facilitate information retrieval and exploration. Many of the long-term users turn to GeneCards to quickly access information about the function of very large sets of genes, for example in the realm of large-scale expression studies using 'DNA chip' technology or two-dimensional protein electrophoresis. AVAILABILITY: Freely available at http://bioinformatics.weizmann.ac.il/cards/ Contact: cards@bioinformatics.weizmann.ac.il
Thermodynamic database for protein–nucleic acid
interactions (ProNIT)
Authors: Prabakaran Ponraj , An Jianghong , Gromiha M. Michael , Selvaraj Samuel , Uedaira Hatsuho , Kono Hidetoshi , Sarai Akinori 
Published: July 2002

Abstract
Motivation: Protein–nucleic acid interactions are fundamental to the regulation of gene expression. In order to elucidate the molecular mechanism of protein–nucleic acid recognition and analyze the gene regulation network, not only structural data but also quantitative binding data are necessary. Although there are structural databases for proteins and nucleic acids, there exists no database for their experimental binding data. Thus, we have developed a Thermodynamic Database for Protein–Nucleic Acid Interactions (ProNIT).
Results: We have collected experimentally observed binding data from the literature. ProNIT contains several important thermodynamic data for protein–nucleic acid binding, such as dissociation constant (Kd), association constant (Ka), Gibbs free energy change (ΔG), enthalpy change (ΔH), heat capacity change (ΔCp), experimental conditions, structural information of proteins, nucleic acids and the complex, and literature information. These data are integrated into a relational database system together with structural and functional information to provide flexible searching facilities by using combinations of various terms and parameters. A www interface allows users to search for data based on various conditions, with different display and sorting options, and to visualize molecular structures and their interactions.
Availability: ProNIT is freely accessible at the URL http://www.rtc.riken.go.jp/jouhou/pronit/pronit.html.
Contact: sarai@rtc.riken.go.jp
* To whom correspondence should be addressed.
PCSB—a program collection for structural biology and
biophysical chemistry
Authors: Hofmann A. , Wlodawer A. 
Published: July 2002

Abstract
We present the first package of Java classes specifically aimed at the handling of structural and biophysical problems. To enable object-oriented programming a basis of fundamental Java classes is required which deals with basic operations of vectors, matrices, amino acid sequences, crystal symmetries and PDB files. Five classes, which carry out these basic operations, were constructed and bundled together with several utility functions in the PCSB package. Furthermore, to demonstrate their applicability and to obtain programs handling common tasks in structural laboratories, we present the first six applications of PCSB. All applications are portable to different platforms and require only the Java Runtime Environment to be installed on the system.
Availability: http://www24.brinkster.com/hofmanna/pcsb/
Contact: hofmanna@ncifcrf.gov
Supplementary information: A manual for PCSB describing the Java classes as well as the applications is available as PDF file.
* To whom correspondence should be addressed.
STOCKS: STOChastic Kinetic Simulations of biochemical systems
with Gillespie algorithm
Authors: Kierzek Andrzej M. 
Published: July 2002

Abstract
Motivation: The availability of a huge amount of molecular data concerning various biochemical reactions provoked numerous attempts to study the dynamics of cellular processes by means of kinetic models and computer simulations. Biochemical processes frequently involve small numbers of molecules (e.g. a few molecules of a transcriptional regulator binding to one ‘molecule’ of a DNA regulatory region). Such reactions are subject to significant stochastic fluctuations. Monte Carlo methods must be employed to study the functional consequences of the fluctuations and simulate processes that cannot be modelled by continuous fluxes of matter. This provides the motivation to develop software dedicated to Monte Carlo simulations of cellular processes with the rigorously proven Gillespie algorithm.
Results: STOCKS, software for the stochastic kinetic simulation of biochemical processes is presented. The program uses a rigorously derived Gillespie algorithm that has been shown to be applicable to the study of prokaryotic gene expression. Features dedicated to the study of cellular processes are implemented, such as the possibility to study a process in the range of several cell generations with the application of a simple cell division model. Taking expression of Escherichia coli beta-galactosidase as an example, it is shown that the program is able to simulate systems composed of reactions varying in several orders of magnitude by means of reaction rates and the numbers of molecules involved.
Availability: The software is available at ftp://ibbrain.ibb.waw.pl/stocksand http://www.ibb.waw.pl/stocks.
Supplementary information: Parameters of the model of prokaryotic gene expression are available in example files of software distribution.
Contact: andrzejk@ibb.waw.pl
ProbeMatchDB—a web database for finding equivalent probes
across microarray platforms and species
Authors: Wang Pinglang , Ding Fei , Chiang Hsienyuan , Thompson Robert C. , Watson Stanley J. , Meng Fan 
Published: July 2002

Abstract
Summary: ProbeMatchDB is a web-based database designed to facilitate the search of EST/cDNA sequences or STS markers that can be used to represent the same gene across different microarray platforms and species. It can be used for finding equivalent EST clones in the Research Genetics sequence verified clone set based on results from Affymetirx GeneChip®s. It will also help to identify probes representing orthologous genes across human, mouse and rat on different microarray platforms.
Availability: The database is accessible at http://brainarray.mhri.med.umich.edu/MARRAY/BC_ASP/brainarray.htm by clicking the ‘Query ProbeMatchDB’ link.
Contact: mengf@umich.edu
Cell‐selective intracellular delivery of a foreign enzyme to endothelium in vivo using vascular immunotargeting
Authors: SCHERPEREEL ARNAUD , WIEWRODT RAINER , CHRISTOFIDOU‐SOLOMIDOU MELPO , GERVAIS RADJ , MURCIANO JUAN‐CARLOS , ALBELDA STEVEN M. , MUZYKANTOV VLADIMIR R. 
Published: July 2002

ABSTRACTVascular immunotargeting, the administration of drugs conjugated with antibodies to endothelial surface antigens, has the potential for drug delivery to the endothelium. Our previous cell culture studies showed that biotinylated antibodies to PECAM‐1 (a highly expressed endothelial surface antigen) coupled with streptavidin (SA, a cross‐linking protein that facilitates anti‐PECAM internalization and targeting) may provide a carrier for the intracellular delivery of therapeutic enzymes. This paper describes the PECAM‐directed vascular immunotargeting of a reporter enzyme (β‐galactosidase, β‐Gal) in intact animals. Intravenous injection of [125I]SA‐β‐Gal conjugated with either anti‐PECAM or IgG led to a high 125I uptake in liver and spleen, yet β‐Gal activity in these organs rapidly declined to the background levels, suggesting rapid degradation of the conjugates. In contrast, anti‐PECAM/[125I]SA‐β‐Gal, but not IgG/[125I]SA‐β‐Gal, accumulated in the lungs (36.0±1.3 vs. 3.9±0.6% injected dose/g) and induced a marked elevation of β‐Gal activity in the lung tissue persisting for up to 8 h after injection (10‐fold elevation 4 h postinjection). Using histochemical detection, the β‐Gal activity in the lungs was detected in the endothelial cells of capillaries and large vessels. The anti‐PECAM carrier also provided 125I uptake and β‐Gal activity in the renal glomeruli. Predominant intracellular localization of anti‐PECAM/SA‐β‐Gal was documented in the PECAM‐expressing cells in culture by confocal microscopy and in the pulmonary endothelium by electron microscopy. Therefore, vascular immunotargeting is a feasible strategy for cell‐selective, intracellular delivery of an active foreign enzyme to endothelial cells in vivo, and thus may be potentially useful for the treatment of acute pulmonary or vascular diseases.—Scherpereel, A., Wiewrodt, R., Christofidou‐Solomidou, M., Gervais, R., Murciano, J.‐C., Albelda, S. M., Muzykantov, V. R. Cell‐selective intracellular delivery of a foreign enzyme to endothelium in vivo using vascular immunotargeting. FASEB J. 15, 416‐426 (2001).
Complex behavior in solution of homodimeric SecA
Authors: Woodbury Ronald L. , Hardy Simon J.S. , Randall Linda L. 
Published: July 2002

AbstractSecA, a homodimeric protein involved in protein export in Escherichia coli, exists in the cell both associated with the membrane translocation apparatus and free in the cytosol. SecA is a multifunctional protein involved in protein localization and regulation of its own expression. To carry out these functions, SecA interacts with a variety of proteins, phospholipids, nucleotides, and nucleic acid and shows two enzymic activities. It is an ATPase and a helicase. Its role during protein localization involves interaction with the precursor polypeptides to be exported, the cytosolic chaperone SecB, and the SecY subunit of the membrane‐associated translocase, as well as with acidic phospholipids. At the membrane, SecA undergoes a cycle of binding and hydrolysis of ATP coupled to conformational changes that result in translocation of precursors through the cytoplasmic membrane. The helicase activity of SecA and its affinity for its mRNA are involved in regulation of its own expression. SecA has been reported to exist in at least two conformational states during its functional cycle. Here we have used analytical centrifugation, as well as column chromatography coupled with multiangle light scatter, to show that in solution SecA undergoes at least two monomer‐dimer equilibrium reactions that are sensitive to temperature and to concentration of salt.
A Triboelectric Nanocomposite for Sterile Sensing, Energy Harvesting, and Haptic Diagnostics in Interventional Procedures from Surgical Gloves
Authors: Salvadores Fernandez Carmen , Jaufuraully Shireen , Bagchi Biswajoy , Chen Wenqing , Datta Priyankan , Gupta Priya , David Anna L. , Siassakos Dimitrios , Desjardins Adrien , Tiwari Manish K. 
Published: February 2023

AbstractAdvanced interfacial engineering has the potential to enable the successful realization of three features that are particularly important for a variety of healthcare applications: wettability control, antimicrobial activity to reduce infection risks, and sensing of physiological parameters. Here, a sprayable multifunctional triboelectric coating is exploited as a nontoxic, ultrathin tactile sensor that can be integrated directly on the fingertips of surgical gloves. The coating is based on a polymer blend mixed with zinc oxide (ZnO) nanoparticles, which enables antifouling and antibacterial properties. Additionally, the nanocomposite is superhydrophobic (self‐cleaning) and is not cytotoxic. The coating is also triboelectric and can be applied directly onto surgical gloves with printed electrodes. The sensorized gloves so obtained enable mechanical energy harvesting, force sensing, and detection of materials stiffness changes directly from fingertip, which may complement proprioceptive feedback for clinicians. Just as importantly, the sensors also work with a second glove on top offering better reassurance regarding sterility in interventional procedures. As a case study of clinical use for stiffness detection, the sensors demonstrate successful detection of pig anal sphincter injury ex vivo. This may lead to improving the accuracy of diagnosing obstetric anal sphincter injury, resulting in prompt repair, fewer complications, and improved quality of life.
A Polypyrrole‐Polycarbonate Polyurethane Elastomer Alleviates Cardiac Arrhythmias via Improving Bio‐Conductivity
Authors: Fadle Aziz Monir Riasad , Wlodarek Lukasz , Alibhai Faisal , Wu Jun , Li Shuhong , Sun Yu , Santerre J. Paul , Li Ren‐Ke 
Published: February 2023

AbstractMyocardial fibrosis, resulting from myocardial infarction (MI), significantly alters cardiac electrophysiological properties. As fibrotic scar tissue forms, its resistance to incoming action potentials increases, leading to cardiac arrhythmia, and eventually sudden cardiac death or heart failure. Biomaterials are gaining increasing attention as an approach for addressing post‐MI arrhythmias. The current study investigates the hypothesis that a bio‐conductive epicardial patch can electrically synchronize isolated cardiomyocytes in vitro and rescue arrhythmic hearts in vivo. A new conceived biocompatible, conductive, and elastic polyurethane composite bio‐membrane, referred to as polypyrrole‐polycarbonate polyurethane (PPy‐PCNU), is developed, in which solid‐state conductive PPy nanoparticles are distributed throughout an electrospun aliphatic PCNU nanofiber patch in a controlled manner. Compared to PCNU alone, the resulting biocompatible patch demonstrates up to six times less impedance, with no conductivity loss over time, as well as being able to influence cellular alignment. Furthermore, PPy‐PCNU promotes synchronous contraction of isolated neonatal rat cardiomyocytes and alleviates atrial fibrillation in rat hearts upon epicardial implantation. Taken together, epicardially‐implanted PPy‐PCNU could potentially serve as a novel alternative approach for the treatment of cardiac arrhythmias.
Piezoelectric Bioactive Glasses Composite Promotes Angiogenesis by the Synergistic Effect of Wireless Electrical Stimulation and Active Ions
Authors: Li Changhao , Zhang Siyu , Yao Yichen , Wang Yanlan , Xiao Cairong , Yang Bo , Huang Jingyan , Li Weichang , Ning Chengyun , Zhai Jinxia , Yu Peng , Wang Yan 
Published: February 2023

AbstractInsufficient angiogenesis frequently occurs after the implantation of orthopedic materials, which greatly increases the risk of bone defect reconstruction failure. Therefore, the development of bone implant with improved angiogenic properties is of great importance. Mimicking the extracellular matrix clues provides a more direct and effective strategy to modulate angiogenesis. Herein, inspired by the bioelectrical characteristics of the bone microenvironment, a piezoelectric bioactive glasses composite (P‐KNN/BG) based on the incorporation of polarized potassium sodium niobate is constructed, which could effectively promote angiogenesis. It is found that P‐KNN/BG has exceptional wireless electrical stimulation performance and sustained active ions release. In vitro cell experiments reveal that P‐KNN/BG enhances endothelial cell adhesion, migration, and differentiation via activating the eNOS/NO signaling pathway, which might be contributed to cell membrane hyperpolarization induced by wireless electrical stimulation increase the influx of active ions into the cells. In vivo chick chorioallantoic membrane experiment demonstrates that P‐KNN/BG shows excellent pro‐angiogenic capacity and biocompatibility. This work broadens the current understanding of bioactive materials with bionic electrical properties, which brings new insights into the clinical treatment of bone defect repair.
Manipulation of Arbitrary Polarizations and Phases Based on Metasurfaces
Authors: Liu Wei , Zhang Lei , Ke Jun Chen , Liang Jing Cheng , Dai Jun Yan , Cheng Qiang , Cui Tie Jun 
Published: February 2023

AbstractPolarization and phase are two essential properties of electromagnetic (EM) waves. A transmissive metasurface is proposed that can simultaneously manipulate the polarization and phase of the EM waves. The design has a powerful capability of rotating the polarization to any desired azimuth direction for a linearly polarized (LP) wave and achieving the cross‐polarization conversion for a circularly polarized (CP) wave. Meanwhile, the transmission phase of the cross‐polarization can be dynamically controlled for the CP wave. The proposed metasurface is composed of two types of substrate‐integrated waveguides (SIW) in a cross arrangement, which has an insertion loss of less than 0.3 dB from 9.7 to 10.3 GHz. Some samples are fabricated and measurements are performed, which are in satisfactory agreement with the theoretical and simulated results, indicating the feasibility of the proposed method. It is believed that the proposed design has many potential applications in the fields of imaging, communication, and radar systems.
Advancements in the Preparation of 4H‐Chromenes: An Overview
Authors: Wen Zhong , Yang Kai‐Cheng , Deng Jun‐Feng , Chen Long 
Published: February 2023

AbstractFunctionalized 4H‐chromenes represent one class of the most important structural scaffolds in both synthetic and medicinal chemistry. They often appear in an arrange of biological natural products, pharmaceutical agents and drug candidates. The significance has stimulated the development of efficient methodologies for the synthesis of such compounds. In this review, a comprehensive discussion on different synthetic approaches to 4H‐chromenes has been presented with an emphasis on reaction features and mechanisms. Three main categories are outlined: 1) nucleophilic addition to 2H‐chromene derivatives, 2) 4H‐chromene ring formation involved cycloaddition or cyclization reactions, and 3) miscellaneous reactions.magnified image
A Pathway into Metaverse: Gesture Recognition Enabled by Wearable Resistive Sensors
Authors: Duan Shengshun , Zhao Fangzhi , Yang Huiying , Hong Jianlong , Shi Qiongfeng , Lei Wei , Wu Jun 
Published: February 2023

AbstractHand gesture recognition is of great importance for human–Metaverse interaction. The human hand is relatively smaller, with very complex articulations than the entire human body. Therefore, precise hand gesture recognition, especially in complicated environments, is still a great challenge. Wearable resistive sensors that could directly characterize joint movements are one of the most promising technologies for hand gesture recognition due to their easy integration, low cost, and simple signal acquisition. Here, we summarize common categories of wearable resistive sensors for hand gesture recognition and review the recent advances. Besides, common strategies for improving waterproofness (molecular design, material modification, and interfacial encapsulation) are also outlined. Perspectives on the advantages of combining machine vision and resistive sensors for accurate hand gesture recognition and dynamic hand gesture tracking are then provided. We hope this review could inspire future research in wearable technologies for human–Metaverse systems.
Synthesis of Erythrocyte Nanodiscs for Bacterial Toxin Neutralization
Authors: Sun Lei , Wang Dan , Noh Ilkoo , Fang Ronnie H. , Gao Weiwei , Zhang Liangfang 
Published: February 2023

AbstractNanodiscs are a compelling nanomedicine platform due to their ultrasmall size and distinct disc shape. Current nanodisc formulations are made primarily with synthetic lipid bilayers and proteins. Here, we report a cellular nanodisc made with human red blood cell (RBC) membrane (denoted “RBC‐ND”) and show its effective neutralization against bacterial toxins. In vitro, RBC‐ND neutralizes the hemolytic activity and cytotoxicity caused by purified α‐toxin or complex whole secreted proteins (wSP) from methicillin‐resistant Staphylococcus aureus bacteria. In vivo, RBC‐ND confers significant survival benefits for mice intoxicated with α‐toxin or wSP in both therapeutic and prevention regimens. Moreover, RBC‐ND shows good biocompatibility and biosafety in vivo. Overall, RBC‐ND distinguishes itself by inheriting the biological functions of the source cell membrane for bioactivity. The design strategy of RBC‐ND can be generalized to other types of cell membranes for broad applications.
Giving Gold Wings: Ultrabright and Fragmentation Free Mass Spectrometry Reporters for Barcoding, Bioconjugation Monitoring, and Data Storage
Authors: Dominique Nathaniel L. , Jensen Isabel M. , Kaur Gurkiran , Kotseos Chandler Q. , Boggess William C. , Jenkins David M. , Camden Jon P. 
Published: February 2023

AbstractThe widespread application of laser desorption/ionization mass spectrometry (LDI‐MS) highlights the need for a bright and multiplexable labeling platform. While ligand‐capped Au nanoparticles (AuNPs) have emerged as a promising LDI‐MS contrast agent, the predominant thiol ligands suffer from low ion yields and extensive fragmentation. In this work, we develop a N‐heterocyclic carbene (NHC) ligand platform that enhances AuNP LDI‐MS performance. NHC scaffolds are tuned to generate barcoded AuNPs which, when benchmarked against thiol‐AuNPs, are bright mass tags and form unfragmented ions in high yield. To illustrate the transformative potential of NHC ligands, the mass tags were employed in three orthogonal applications: monitoring a bioconjugation reaction, performing multiplexed imaging, and storing and reading encoded information. These results demonstrate that NHC‐nanoparticle systems are an ideal platform for LDI‐MS and greatly broaden the scope of nanoparticle contrast agents.