bluuebunny/crossref_metadata_2025_split huggingface dataset:
Can Triglyceride/Glucose Index (TyG) and Triglyceride/HDL-Cholesterol Ratio (TG/HDL-c) Predict Diabetes in Pregnant Women?
Authors: Ergani Seval Yılmaz , İlhan Tolgay Tuyan , Çakır Betül Tokgöz , Bayraktar Burak , Bucak Mevlüt , İbanoglu Mujdecan , Yücel Kadriye Yakut , Erdoğan Kadriye , İskender Can Tekin , Üstün Yaprak Engin 
Published: April 2023

Abstract
Purpose In this study, we investigated whether the Triglyceride/Glucose index(TyG) and Triglyceride/HDL-Cholesterol Ratio(TG/HDL-c) are measured in the first trimester, if it can give an idea about gestational diabetes mellitus.Methods Twenty-five patients diagnosed with gestational diabetes and 52 control groups were included in the study. Insulin-controlled diabetes and diet-controlled diabetes were included in the GDM diagnoses. Fasting glucose and plasma lipid profiles measured in the first trimester, including TG, HDL-c, were noted and proportioned and evaluated by ROC analysis.Results Triglycerides (133 ± 40 mg/dL vs 100 ± 54 mg/dL), TyG index (15.0 ± 8.9 vs 8.8 ± 5.0), and TG/HDL-C ratio (3.3 ± 2.6 vs 1.9 ± 2.6) were significantly higher in the GDM group than in the control group (p = 0.01, p = 0.01, and p = 0.01, respectively). Mean newborn birth weight > 90. percentile was significantly higher in the GDM group than in the control group, although preterm births were more common (p = 0.02). The optimal cut off value for TyG index was 10.4, sensitivity was 76% (95% CI; 55–90), specificity was 77% (95% CI; 62–86), positive likelihood ratio was 3.04 (95% CI; 1.81–5.11), negative likelihood ratio was 0.32 (95% CI; 0.16–0.65), and area under the receiver operating characteristic curve (AUC) was 0.765. Optimal cut off value for TG/HDL-C ratio was 2.3, sensitivity was 76% (95% CI; 55–91), specificity was 69% (95% CI; 55–81), positive likelihood ratio was 2.47 (95% CI; 1.55–3.93%), negative likelihood ratio was 0.35 (95% CI; 0.17–0.71), and AUC was 0.697.Conclusions TyG and TG/HDL-C ratio measured in the first trimester are thought to predict GDM better than fasting plasma glucose.
Intelligent auxiliary design of subway station building space based on deep learning
Authors: An Jiang , zhang jiuhong , Ma Mingxiao , Wu Yuying 
Published: April 2023

Abstract
This paper aims to study the generation of spatial function layout of subway stations assisted by deep learning, and train the point cloud data of subway stations based on the Pointnet + + model in deep learning. The point cloud data of subway stations comes from the subway station data of large and medium-sized cities collected and processed by the author. After training and verification, the following conclusions are drawn: (1) It has been verified that the spatial deep learning of buildings in the form of point clouds is highly feasible, and the point cloud format of the architectural space model is fully compatible under the Pointnet + + model. (2) Verified the effectiveness of Pointnet + + for semantic segmentation and prediction of subway station cloud information. The results show that the predicted data has 60%+MIOU (MeanIoU average intersection and union ratio) and 75%+Acc (Accuracy). This paper uses an interdisciplinary research method to combine deep learning of 3D point cloud data with architectural design, breaking through the current situation of using 2D images as research objects, and avoiding the application of "deep learning" to 2D images. Objects cannot accurately describe the limitations of 3D space, providing architects with more intuitive and diverse design assistance.
Are Motor Imagery Ability scores related to cortical activity during gait imagery?
Authors: Putzolu Martina , Samogin Jessica , Bonassi Gaia , Cosentino Carola , Mezzarobba Susanna , Botta Alessandro , Avanzino Laura , Mantini Dante , Vato Alessandro , Pelosin Elisa 
Published: April 2023

Abstract
Motor imagery (MI) is the mental execution of actions without overt movements that depends on the ability to imagine. We explored whether this ability could be related to the cortical activity of the brain areas involved in the MI network. To this goal, brain activity was recorded using high-density electroencephalography (hdEEG) in nineteen healthy adults while visually imagining walking on a straight path. We extracted Event-Related Desynchronizations (ERDs) in the β band, and we measured MI ability via (i) the Kinesthetic and Visual Imagery Questionnaire (KVIQ), (ii) the Vividness of Movement Imagery Questionnaire-2 (VMIQ), and (iii) the Imagery Ability (IA) score. We then used Pearson's and Spearman's coefficients to correlate MI ability scores and average ERD power (avgERD). VMIQ was positively correlated with avgERD of frontal and cingulate areas, whereas IA SCORE was positively correlated with avgERD of left inferior frontal and superior temporal regions. Stronger activation of the MI network was related to better scores of MI ability evaluations, supporting the importance of testing MI ability during MI protocols. This result will help to understand MI mechanisms and develop personalized MI treatments for patients with neurological dysfunctions.
Causal relationship between Physical activity, leisure sedentary behaviors and hip/keen osteoarthritis risk: a Mendelian randomization study
Authors: Liu Shen , yang yubiao , Song Yuxuan , ma pengyi , Han Mingyuan , Hao Dingyu , Ma Boyuan , Zhou Xianhu 
Published: April 2023

Abstract
Objective: We used Mendelian randomization to examine the causal effects of physical activity (PA) and leisure sedentary behaviour (LSB) on the risk of knee and hip osteoarthritis (KOA/HOA).
Methods: We used large-scale datasets of PA (N=377,000) and LSB (N=422,218) as exposures, and KOA (N=403,124), HOA (N=398,873), and KOA and/or HOA (N=417,596) as outcomes. We applied inverse-variance weighted, MR-Egger and weighted median methods to estimate causal effects. The validity of the instrumental variables was assessed using Cochran’s Q test, MR-Egger intercept test and MR-PRESSO test. We performed leave-one-out analysis and funnel plot to examine the influence of individual variants and potential publication bias. We also conducted risk factor analyses to explore possible mediators.
Results: The genetic prediction of PA increased the risk of KOA (OR: 1.29; P: 0.02). Television viewing raised the risk of KOA (OR: 1.34; P: 5.30e-5) and HOA (OR: 1.66; P: 1.77e-15). However, computer use lowered the risk of KOA (OR: 0.80; P: 0.01) and KOA and/or HOA (OR: 0.83; P: 0.01). No effect of PA, fraction of accelerations >425 milli-gravities and driving on KOA/HOA was observed. Risk factor analysis indicated that multiple risk factors may mediate the above causal relationships.
Radical resection of advanced tongue cancer and one-stage total tongue reconstruction
Authors: Hu Bin-Tao , Wang Xu , Sun Rong-Hao , Cai Yong-Chong , Li Chao 
Published: April 2023

Abstract
Background:The dysfunction of the tongue caused after total tongue resection is a major challenge for surgeons.The purpose of this study was to explore the functional recovery and survival of patients after radical resection of advanced tongue cancer and one-stage total tongue reconstruction with laryngeal preservation.
Methods:Twelve cases of tongue reconstruction with pectoralis major myocutaneous (PMMF) flap or anterolateral thigh (ALT) flap from 2012 to 2020 were analyzed. The speech function, tongue flexibility, deglutition, and patient satisfaction with the donor appearance were evaluated at 3 and 6 months after operation.The survival status was recorded at 1,3, and 5 years after surgery.
Results:There were 7 males and 5 females, with an average of 48.75 years. 5 cases with (PMMF) flap , and 7 cases with (ALT) flap ,the overall flap survival rate was 100% (12 / 12). Postoperative tracheal tube removal rate was 100%(12 / 12).9 cases had a history of secondary or even multiple surgeries or chemoradiotherapy,8 cases concomitanted adjuvant chemoradiotherapy after surgery.Pathological types included:10 cases of squamous cell carcinoma , 1 case of sarcomatoid carcinoma(SC) and 1 case of adenoid cystic carcinoma（ACC）. At 6 months after surgery, 3 (27.2%) of 11 patients (1 dead at 4 months) had normal language, 4 (36.4%) had near-normal language, and 4 (36.4%) had vague speech. In addition, 3 (27.2%) patients had a normal diet, 1 (9.1%) patient had a soft diet, 6 (54.5%) patients had a liquid diet, and 1 (9.1%) patient still required tube feeding. Six months after the operation, the tongue was basically in a fixed state, and the range of motion of the tongue did not improve significantly(P=0.217). The patients' satisfaction with the recovery of the donor site was (10/11) 90.9%.Compared with three months after surgery,the articulation of speech（P=0.024）, swallowing, chewing and eating （P=0.033）were significantly improved at six months after surgery . The 1-year, 3-year and 5-year survival rates were 66.66%, 33.33% and 25.0%, respectively.
Conclusion:Total glossectomy is most often used as salvage therapy in patients with stage IV primary cancer or in recurrent cases.Reconstruction after total glossectomy using larger tissue flaps such as ALT or PMMF flaps has acceptable risk of complications and affords most patients the potential for intelligible speech and tube-feed-free nutrition with improved quality of life and reasonable long-term survival.
Gender differences in prevalence and associated factors of metabolic syndrome in first-treatment and drug-naïve schizophrenia patients
Authors: Zeng Kuan , Wang Shuo , Zhang Lin , Zhang Yanting , Ma Jun 
Published: April 2023

Abstract
Background: Metabolic syndromes (MetS) are clinical syndromes involving multiple pathological states with distinct gender differences clinical patterns. As a serious psychiatric disorder, the prevalence of MetS is significantly higher in this subgroup of the population with schizophrenia (Sch). The aim of this paper is to report gender differences in the prevalence, associated factors and severity-related factors of MetS in first-treatment and drug-naïve (FTDN) Sch patients.
Methods: A total of 668 patients with FTDN Sch were included in this study. Demographic and general clinical information on the included population was collected and the severity of their psychopathology was assessed.
Results: In the target group, the prevalence of MetS was significantly higher in women (13.44%, 57/424) than in men (6.56%, 16/244). In the males, waist circumference (WC), fasting blood glucose (FBG), diastolic blood pressure (DBP), and triglycerides (TG) were risk factors for the diagnosis of MetS. While, systolic blood pressure (SBP), TG, total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), and platelet (PLT) were risk factors for the females. More importantly, we found that age, LDL-C, Positive and Negative Symptom Scales (PANSS) scores and blood creatinine (CRE) were risk factors for higher MetS scores, while onset age and hemoglobin (HGB) were protective factors.
Conclusion: There are gender differences in the prevalence of MetS in FTDN Sch patients, with a higher prevalence in women. Factors influencing MetS and its severity differ extensively between male and female patients. Targeted management strategies should be differentiated for patients of different genders in clinical practice.
Quality Assessment of Matching Single-Cone Obturation in Canals Shaped with Different NiTi Systems: A Micro-CT Study
Authors: Öztürk Ayşenur , Haznedaroğlu Faruk , Basmacı Gülsüm Kutlu 
Published: April 2023

Abstract
OBJECTIVES: This study is aimed to evaluate the compatibility of single-cone filling technique in reciprocal and rotationally formed canals in using Micro-CT (Micro-computed tomography).
MATERIALS AND METHODS: The mesiolingual and mesiobuccal canals of the mesial roots of 30 mandibular molars were used for this study, concluding 60 root canals. The samples were split into two groups, 30 of which were shaped with the HyFlex EDM system and 30 with the WaveOne Gold system. In both groups, one of the canals of the shaped roots was filled with the lateral compaction and the other with a matched single-cone technique with a bioceramic-based root canal sealer, BioRoot RCS. The percentage of voids in the canal were evaluated by micro-CT radiograph before and after obturation.
RESULTS: Regardless of the kinematics used, the single-cone technique left significantly fewer voids than the lateral compaction. In the regional analysis, the groups filled with the single-cone technique had significantly better results than the lateral compaction group in the middle and coronal thirds. In the kinematics comparison, the group shaped with the reciprocal WaveOne Gold system and filled with the single-cone system had the best results.
CONCLUSIONS: The reciprocal nickel-titanium (NiTi) system is more effective shaping method than the rotational NiTi system. The matching single-cone technique had significantly better results than the lateral compaction technique. CLINICAL RELEVANCE: According to results of this study, matching single-cone technique has more successful results than the lateral compaction.
Design of a wearable, flexible Microstrip patch antenna for the detection of breast cancer
Authors: S Julius Fusic , T Sugumari , R Sitharthan 
Published: April 2023

Abstract

Breast cancer is a medical condition characterized by the uncontrolled proliferation of cells in the breast tissue. Breast cancer can originate from various parts of the breast, and methods such as Breast ultrasound, Diagnostic mammogram, Breast magnetic resonance imaging, and Biopsy are currently used for its diagnosis. However, these methods have certain limitations, and their size can be a hindrance. To overcome this, low-power, flexible antennas can be designed for bio-communication between medical equipment and external instrumentation. Flexible and wearable antennas have advantages such as affordability, ease of fabrication, and high gain. In this article, a microstrip patch antenna operating at 2.45GHz and made of polyamide material is designed using HFSS software. The simulation results show the patch antenna has a gain of 1dB, -14.81dB return loss at 2.45GHz based on |S11|≤ - 10dB. The directive radiation pattern with axial ratio of 63.39dB and VSWR ≤ 3. Furthermore, the hardware development of proposed antenna with polyamide substrate provides the resonance frequency nearing to simulation results as 2.318GHz with return loss of -28.19dB. Based on mathematical analysis, simulation and hardware results, the proposed antenna is a superior option for breast cancer detection.
The Impact of Paternal Age on Cumulative Assisted Reproductive Technologies Outcomes
Authors: Farabet Clemence , Pirtea Paul , PhrD Achraf Benammar , Ziegler Dominique , Marchiori Claire , Vallée Alexandre , Ayoubi Jean-Marc 
Published: April 2023

Abstract
Objective: To investigate the impact of paternal age on cumulative live birth rate in ART
Design: Retrospective single center cohort study
Patient(s): All female patients 18-43 years old, and males 18-60 years old who performed their first ART cycle between January 2018 and December 2020 were included.
Intervention(s): N/A
Main Outcome Measure(s): The primary outcome, cumulative live birth rate (cLBR), was estimated following fresh or frozen embryo transfers issued from an ART cycle. Secondary outcomes included: cumulative pregnancy rate (cPR), miscarriage rate. subgroups analyses were performed, as follows: males <45 and ³ 45; female <35,35-38, and >38 years.
Result(s): 2,358 couples were included. Male patients within both age groups had sperm quantity divided in 2 groups: normal and abnormal, that were found to be in significantly equal proportions. There was significantly more tobacco use in the male group ³45. cPR was 0.5301 in the group <45 and 0.3111 in the group ³45, p < 0.001. Analysis according to the female age, in the female group > 38: cLBR rate was 0.26 for male <45 and 0.19 for male ³45, p=0.061. Also, cPR was 0.34 in the male group <45 and 0.21 in the group ³45, p< 0.001. In the female group 35-38 cLBR was 0.44 in the male group <45 and 0.3 in the group ³45, p=0.031. cPR was 0.49 in the male group <45 and 0.34 in the group ³ 45, p=0.036. Within the female group <35, we observed non-significant results. Miscarriage rate results weren’t significantly different for women ≤38.
Conclusion: According to our result, male age ³45 has a significant impact on cumulative ART outcomes.
Impact statement: We report that male age ³45 has a significant impact on cumulative ART outcomes, an effect particularly pronounced in women over 38 years of age.
Geochemistry of apatites from pre–shield and post–shield basalts and their petrogenetic implications: A case study of the Naitoushan basalt and Heishigou dike in the Changbaishan Tianchi volcano, NE China
Authors: Xu Zhitao , Sun Liying , Ye Xiqing , Li Zhongwei , Ma Fei , Jia Lin 
Published: April 2023

Abstract

This study analyzes apatite via laser ablation multicollector inductively coupled plasma mass spectrometry (LA–MC–ICP–MS) and zircon via LA–ICP–MS to collect U–Pb geochronological data, alkaline feldspar and plagioclase via Rb–Sr isotope chronology and an apatite geochemistry archive for exposed Naitoushan basalt and Heishigou dike in the Changbaishan Tianchi volcano (CTV). These data are used to examine their petrogenesis and to determine the basaltic magmatism origin in CTV. The Naitoushan basalt and Heishigou dike were formed at 22.2–18.7 and 0.230–0.218 Ma, respectively. In situ oxide, volatiles, trace element geochemistry and Sr–Nd isotopes of apatite are provided for two samples. Most apatites occur as an early crystallizing phase forming inclusions in plagioclase and are euhedral or subhedral. They have higher MgO and K2O/Na2O concentrations with lower F and Cl concentrations, Ba, Sr, Nb, Ta, Zr, Hf, K, and Ti depletions, and Th, U, Ce, Pb, P, and Nd enrichments. All apatite samples have enrichment in light rare earth elements (REEs) relative to heavy REEs and relatively homogeneous ratios of Th/U, Zr/Hf, La/Sm, Nd/Tb and Sr–Nd isotopic compositions; thus, their host magmas potentially have the same magmatic origin as oceanic island basalt. The La, Yb, and U contents, the Eu/Eu* and La/Yb values, and the high REE contents in the apatites show a weak crystallization sequence in mafic magma. Combined with previous whole-rock geochemical data, apatite trace element and REE patterns and compositional variations in the rocks are controlled by the crystallization of olivine, pyroxene, plagioclase, and cocrystallizing accessory minerals. This study demonstrates that the pre–shield and post–shield mafic magmas in the CTV were likely derived from an enriched mantle source with a signature of enriched mantle I-type.
Facilitating culturally affirming research experiences for undergraduate Pacific Islander students
Authors: Irish Tobias , Genz Joseph H. , Storie Monique 
Published: April 2023

Abstract
This study addresses issues related to the underrepresentation and lack of persistence of Pacific Islanders in STEM fields by using, as a case study, the experience of 12 undergraduate researchers, each of Pacific Islander descent and upbringing, who navigated their own engaged participation as apprentices in a STEM education research project. The student researchers, --following a traditional model of learning in the Pacific where youth apprentice themselves to their elders in a specialized field of knowledge--participated as members of a research team for the period of at least one full year and were involved in the development, implementation, and analysis of culturally responsive research protocols. Throughout the process, the apprentices produced personal narrative reflections on their own cultural identities and understandings and relayed their experience as apprentice researchers in the research project. The results indicate that as a result of their engagement in this apprenticeship model for undergraduate research experiences (URE), the student apprentices gained a deeper awareness of respect as a core value in engaging in culturally responsive research. It also caused them to reflect on the importance of their own ancestral roots, life experiences and cultural identities, including a deeper appreciation for how science is practiced in their home communities. Lastly, this apprenticeship URE model draws from traditional ways of learning in many Pacific Islander cultures and as a result, resonated with them culturally in that it reflected a particular way of learning they were familiar with. We argue that such insights can be used to better inform education programs and employers about the unique factors that influence Pacific Islanders and other Indigenous peoples so that they can provide opportunities that are seen as relevant and meaningful.
Rapid detection of residual chlorpyrifos and pyrimethanil on fruit surface by surface- enhanced Raman spectroscopy integrated with deep learning approach
Authors: Dong Xuan , Liu Chao , Dong Shanshan , Wang Shenghao , Huang Qing 
Published: April 2023

Abstract
Chlorpyrifos and pyrimethanil are widely used insecticides/fungicides in agriculture. The residual pesticides/fungicides remaining in fruits and vegetables may do harm to human health if they are taken without notice by the customers. Therefore, it is important to develop methods and tools for the rapid detection of pesticides/fungicides in fruits and vegetables, which are highly demanded in the current markets. Surface-enhanced Raman spectroscopy (SERS) can achieve trace chemical detection, while it is still a challenge to apply SERS for the detection and identification of mixed pesticides/fungicides. In this work, we tried to combine SERS technique and deep learning spectral analysis for the determination of mixed chlorpyrifos and pyrimethanil on the surface of fruits including apples and strawberries. Especially, the multi-channel convolutional neural networks-gate recurrent unit (MC-CNN-GRU) classification model was used to extract sequence and spatial information in the spectra, so that the accuracy of the optimized classification model could reach 99% even when the mixture ratio of pesticide/fungicide varied considerably. This work therefore demonstrates an effective application of using SERS combined deep learning approach to rapid detection and identification of different mixed pesticides in agricultural products.
Integrative analysis reveals an enhancer based prognostic risk model for non-small cell lung cancer
Authors: Zhang Weiguo , Ke Yizhong , Cheng Yunzhang , Liu Xiyu , Jin Mingming , Huang Gang 
Published: April 2023

Abstract
The study used integratively analyzed methylation data and expression data on non-small cell lung cancer (NSCLC). From the methylation data, we obtained 19,784 differentially methylated probes (DMPs) and studied the distribution of these DMPs. The DMPs were enriched by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG). Subsequently, we focused on the 6089 DMPs of enhancers, which accounted for a relatively large proportion. We used weighted gene co-expression network analysis (WGCNA) to identify NSCLC related genes from the DMPs of enhancers. Least absolute shrinkage and selection operator (LASSO) regression and Cox regression algorithms were used to identify characteristic genes and construct a prognostic risk model based on the expression data. The prognostic risk model areas under the curve (AUC) of 3-, 5-, and 10-year time-dependent receiver operating curves (ROC) were all higher than 0.7 in both the training set and validation set, and the prognostic risk model had higher predictive capacity than other clinical variables. Finally, we plotted a nomograph for 3, 5, and 10 years. In conclusion, the prognostic risk model had high predictive capacity for long term overall survival (OS) of patients with NSCLC.