bluuebunny/crossref_metadata_2025_split huggingface dataset:
Elucidating the NB-UVB mechanism by comparing transcriptome alteration on the edge and center of psoriatic plaques
Authors: Boonpethkaew Suphagan , Meephansan Jitlada , Charoensuksira Sasin , Jumlongpim Onjira , Tangtanatakul Pattarin , Wongpiyabovorn Jongkonnee , Komine Mayumi , Morita Akimichi 
Published: March 2023

AbstractNarrow band-ultraviolet B (NB-UVB) is an effective treatment for psoriasis. We aim to generate a potential mechanism of NB-UVB through comparing the transcriptomic profile before and after NB-UVB treatment between the peripheral edge of lesional skin (PE skin) and the center of lesional skin (CE skin) on the basis of molecular mechanisms of these two areas display different downstream functions. More than one-fourth of the NB-UVB-altered genes were found to be plaque-specific. Some of them were psoriasis signature genes that were downregulated by NB-UVB in, both, PE and CE skin (core alteration), such as IL36G, DEFB4A/B, S100A15, KRT16, and KRT6A. After NB-UVB treatment, the activity score of upstream cytokines, such as interferons, interleukin (IL)-6, IL-17, and IL-22 in pathogenesis decreased. In addition, NB-UVB could restore normal keratinization by upregulating LORICRIN and KRT2, particularly in the CE skin. Finally, we illustrated that NB-UVB is capable of suppressing molecules from the initiation to maintenance phase of plaque formation, thereby normalizing psoriatic plaques. This finding supports the usefulness of NB-UVB treatment in clinical practice and may help in the development of new treatment approaches in which NB-UVB treatment is included for patients with psoriasis or other inflammatory skin diseases.
The influence of Cenozoic Eurasia-Arabia convergence on the Southeast Arabian Foreland Basin: new geochronological and geochemical constraints from syn-kinematic carbonate mineralization
Authors: Arboit Francesco , Drost Kerstin , Decarlis Alessandro , Chew David , Hennhoefer Dominik , Ceriani Andrea 
Published: March 2023

AbstractThe Cenozoic succession of the Jabal Hafeet anticline yields the most complete surface expression of the deformation that affected the Southeast Arabian Foreland Basin (SEAFB). The carbonate rocks of the Eocene Rus Formation comprise the core of the Jabal Hafeet anticline and host a network of fractures and carbonate veins associated with dynamic fracture opening and sealing events. These fracture networks developed during the propagation of compressional stresses from the Makran and Zagros fold-and-thrust belts into their foreland basin system (the SEAFB) and are associated with Arabia-Eurasia convergence. Syn-kinematic calcite veins associated with the Cenozoic folding events in the SEAFB were dated by U–Pb LA-ICP-MS carbonate geochronology and characterized further by Raman fluid-inclusion geochemistry. The U–Pb data show that Cenozoic compression linked to the propagation of the Makran fold-and-thrust belt into the SEAFB took place from c. 20 Ma (early Miocene) to c. 2 Ma (mid Pleistocene). Raman fluid-inclusion data reveal the presence of complex hydrocarbons within the parent carbonate-bearing fluids, reflecting a fluid transport pathway between the upper Cenozoic rocks and deeper hydrocarbon-bearing Mesozoic sequences. Combined isotopic and geochemical datasets show that the deformational history of the SEAFB is likely related to the reactivation of inherited deep-seated structures in the upper Cenozoic stratigraphic sequence due to the far-field stress propagation from the Makran belt into the Arabian peninsula, rather than the propagation of a thin-skinned deformation architecture.
Assessing the effectiveness of perimeter lockdowns as a response to epidemics at the urban scale
Authors: de Miguel Arribas Alfonso , Aleta Alberto , Moreno Yamir 
Published: March 2023

AbstractFrom September 2020 to May 2021 Madrid region (Spain) followed a rather unique non-pharmaceutical intervention (NPI) by establishing a strategy of perimeter lockdowns (PLs) that banned travels to and from areas satisfying certain epidemiological risk criteria. PLs were pursued to avoid harsher restrictions, but some studies have found that the particular implementation by Madrid authorities was rather ineffective. Based on Madrid’s case, we devise a general, minimal framework to investigate the PLs effectiveness by using a data-driven metapopulation epidemiological model of a city, and explore under which circumstances the PLs could be a good NPI. The model is informed with real mobility data from Madrid to contextualize its results, but it can be generalized elsewhere. The lowest lockdown activation threshold $$\Theta $$
Θ
considered (14-day cumulative incidence rate of 20 cases per every $$10^5$$

10
5

inhabitants) shows a prevalence reduction $$>20\%$$

>
20
%

with respect to the scenario $$\Theta =10^3$$

Θ
=

10
3

, more akin to the case of Madrid, and assuming no further mitigation. Only the combination of $$\Theta =20$$

Θ
=
20

and mobility reduction $$>90\%$$

>
90
%

can avoid PLs for more than $$>20\%$$

>
20
%

of the system. The combination of low $$\Theta $$
Θ
and strong local transmissibility reduction is key to minimize the impact, but the latter is harder to achieve given that we assume a situation with highly mitigated transmission, resembling the one observed during the second wave of COVID-19 in Madrid. Thus, we conclude that a generalized lockdown is hard to avoid under any realistic setting if only this strategy is applied.
Nanopore Sequencing Discloses Compositional Quality of Commercial Probiotic Feed Supplements
Authors: Kruasuwan Worarat , Jenjaroenpun Piroon , Arigul Tantip , Chokesajjawatee Nipa , Leekitcharoenphon Pimlapas , Foongladda Suporn , Wongsurawat Thidathip 
Published: March 2023

AbstractThe market for the application of probiotics as a livestock health improvement supplement has increased in recent years. However, most of the available products are quality-controlled using low-resolution techniques and un-curated databases, resulting in misidentification and incorrect product labels. In this work, we deployed two workflows and compared results obtained by full-length 16S rRNA genes (16S) and metagenomic (Meta) data to investigate their reliability for the microbial composition of both liquid and solid forms of animal probiotic products using Oxford Nanopore long-read-only (without short-read). Our result revealed that 16S amplicon data permits to detect the bacterial microbiota even with the low abundance in the samples. Moreover, the 16S approach has the potential to provide species-level resolution for prokaryotes but not for assessing yeast communities. Whereas, Meta data has more power to recover of high-quality metagenome-assembled genomes that enables detailed exploration of both bacterial and yeast populations, as well as antimicrobial resistance genes, and functional genes in the population. Our findings clearly demonstrate that implementing these workflows with long-read-only monitoring could be applied to assessing the quality and safety of probiotic products for animals and evaluating the quality of probiotic products on the market. This would benefit the sustained growth of the livestock probiotic industry.
Non-sentinel node metastasis prediction during surgery in breast cancer patients with one to three positive sentinel node(s) following neoadjuvant chemotherapy
Authors: Chun Jung Whan , Kim Jisun , Chung Il Yong , Ko Beom Seok , Kim Hee Jeong , Lee Jong Won , Son Byung Ho , Ahn Sei-Hyun , Lee Sae Byul 
Published: March 2023

AbstractOur aim was to develop a tool to accurately predict the possibility of non-sentinel lymph node metastasis (NSLNM) during surgery so that a surgeon might decide the extent of further axillary lymph node dissection intraoperatively for patients with 1–3 positive sentinel lymph node(s) (SLN) after neoadjuvant chemotherapy. After retrospective analysis of Asan Medical Center (AMC) database, we included 558 patients’ records who were treated between 2005 and 2019. 13 factors were assessed for their utility to predict NSLNM with chi-square and logistic regression with a bootstrapped, backward elimination method. Based on the result of the univariate analysis for statistical significance, number of positive SLN(s), number of frozen nodes, Progesterone Receptor (PR) positivity, clinical N stage were selected for the multivariate analysis and were utilized to generate a nomogram for prediction of residual nodal disease. The resulting nomogram was tested for validation by using a patient group of more recent, different time window at AMC. We designed a nomogram to be predictive of the NSLNM which consisted of 4 components: number of SLN(s), number of frozen nodes, PR positivity, and clinical N stage before neoadjuvant chemotherapy. The Area under the receiver operating characteristics curve (AUC) value of this formula was 0.709 (95% CI, 0.658–0.761) for development set and 0.715 (95% CI, 0.634–0.796) for validation set, respectively. This newly created AMC nomogram may provide a useful information to a surgeon for intraoperative guidance to decide the extent of further axillary surgery.
Development and validation of new predictive equations for resting energy expenditure in physically active boys
Authors: Łuszczki Edyta , Jagielski Paweł , Bartosiewicz Anna , Dereń Katarzyna , Matłosz Piotr , Kuchciak Maciej , Oleksy Łukasz , Stolarczyk Artur , Mazur Artur 
Published: March 2023

AbstractMeasurement or estimation of resting energy expenditure (REE) should be the first step in determining energy demand in physically active boys. The purpose of this study was to develop and validate new equations for resting energy expenditure in male children and adolescents practicing soccer. The cross-sectional studywas carried out among 184 boys in the derivation group and 148 boys in the validation group (mean age 13.20 ± 2.16 years and 13.24 ± 1.75 years, respectively). The calorimeter and device for assessing body composition by bioelectrical impedance analysis (BIA) were used. Model of multiple regression showed that REE can be predicted in this population with Eq. (1) (with height and weight data) or Eq. (2) (with age, height, and fat free mass data). Predictive Eq. (1) had an average error of 51 ± 199 kcal and predictive Eq. (2) − 39 ± 193 kcal. Cohen's d coefficient was 0.2, which confirms the small difference. The bias was 4.7% and 3.9%, respectively. The accuracy was 61.2% in the population for predictive Eq. (1) and 66.2% for predictive Eq. (2). Therefore, the new equations developed and validated in this study are recommended for the estimation of REE in physically active boys, when the use of IC is not feasible or available.
Occurrence and patterns of fin whale songs reveal alternative migration strategies in Svalbard Islands, Norway
Authors: Papale E. , Pelagatti M. , Pedrazzi G. , Buscaino G. 
Published: March 2023

AbstractThe Arctic marine environment is highly affected by global warming with notable changes in habitat conditions, which have great consequences on migrating species. For example, the timing of their migration can be altered leading to changes in their occurrence in suitable areas, which are critical for their survival. In this study, seven years of acoustic data were analysed in Svalbard Islands from 2014 to 2020, revealing that the occurrence of fin whales (Balaenoptera physalus) happened all year-round. The sea surface temperature recorded reveals conditions which could be favorable for these species to persist until the Polar Night. The occurrence of songs indicated that certain individuals did not undertake the migratory journey through the southern breeding grounds, possibly using the area for mating purposes. The analyses of the Inter-Note-Interval (INI) demonstrated that over the years songs with different patterns were found. This suggests that either the fin whales are able to switch their INI patterns or that populations with different INIs are visiting during the Winter. Therefore, this study unveils the undertaking of an alternative strategy to migration movements, and the possible potential origin of the fin whales overwintering in Svalbard.
Air volume flow rate optimization of the guide vanes in an axial flow fan based on DOE and CFD
Authors: Chen Fanbao , Zhu Guanzhang , Xi Danyang , Miao Bin 
Published: March 2023

AbstractThe unreasonable design of guide vanes in the axial fan could have negative effects. In order to enhance the performance, the relationship between the air volume flow rate of the selected axial fan and geometric parameters of guide vanes is firstly analysed by DOE and CFD, and optimal parameters are found by the Gaussian Process method. Results show that the number and total chord of guide vanes have a nonlinear effect on the air volume flow, and the total chord of vanes is the main factor in affecting calculation results. For the particular configuration studied here, the optimal design of guide vanes shows that lessening the chord of vanes by 38 mm and increasing the number of the vanes to 18 could produce more airflow under the same rotation speed.
The utility of airborne hyperspectral and satellite multispectral images in identifying Natura 2000 non-forest habitats for conservation purposes
Authors: Jarocińska Anna , Kopeć Dominik , Niedzielko Jan , Wylazłowska Justyna , Halladin-Dąbrowska Anna , Charyton Jakub , Piernik Agnieszka , Kamiński Dariusz 
Published: March 2023

AbstractAerial hyperspectral and multispectral satellite data are the two most commonly used datasets to identify natural and semi-natural vegetation. However, there is no documented analysis based on data from several areas concerning the difference in the classification accuracy of non-forest Natura 2000 habitat with the use of aerial hyperspectral and satellite multispectral data. Also, there is no recommendation, on which habitat can be classified with sufficient accuracy using free multispectral images. This study aimed to analyse the difference in classification accuracy of Natura 2000 habitats representing: meadows, grasslands, heaths and mires between data with different spectral resolutions and the results utility for nature conservation compared to conventional maps. The analysis was conducted in five study areas in Poland. The classification was performed on multispectral Sentinel-2 (S2) and hyperspectral HySpex (HS) images using the Random Forest algorithm. Based on the results, it can be stated that the use of HS data resulted in higher classification accuracy, on average 0.14, than using S2 images, regardless of the area of the habitat. However, the difference in accuracy was not constant, varying by area and habitat characterisation. Greater differences in accuracy were observed for areas where habitats were characterised by high α-diversity or β-diversity. The HS and S2 data make it possible to create maps that provide a great deal of new knowledge about the distribution of Natura 2000 habitats, which is necessary for the management of protected areas. The obtained results indicate that by using S2 images it is possible to identify, at a satisfactory level, alluvial meadows and grassland. For heaths and mires, using HS data improved the results, but it is also possible to acquire general distribution of these classes, whereas HS images are obligatory for mapping salt, Molinia and lowland hay meadows.
Cardiovascular disease preventive effects of aspirin combined with different statins in the United States general population
Authors: Liu Tao , Zuo Ronghua , Wang Jia , Huangtao Zixuan , Wang Bing , Sun Lifang , Wang Shasha , Li Baoyin , Zhu Zhijian , Pan Yesheng 
Published: March 2023

AbstractThe purpose of this study was to explore the use of aspirin in conjunction with various statins for cardiovascular disease (CVD) prevention in the general population of the United States (U.S.). A total of 3778 people from the National Health and Nutrition Examination Surveys from 2011 to 2018 were included in our analysis. After adjusting for sociodemographic and common cardiovascular risk factors, we used multivariable logistic regression analysis to determine aspirin should be combined with which type of statin for better CVD preventive effects. Subgroup analyses were carried out subsequently. In comparison to the aspirin use alone, the odds ratios with 95% confidence intervals for CVD were 0.43 (0.33, 0.57), 0.69 (0.42, 1.13), 0.44 (0.31, 0.62), 0.34 (0.23, 0.50) and 0.64 (0.49, 0.84) for the combination use of aspirin and atorvastatin, lovastatin, pravastatin, rosuvastatin as well as simvastatin, respectively, in the fully-adjusted model. Aspirin combined with rosuvastatin was more effective in the prevention of individual CVD, including congestive heart failure, coronary heart disease, angina pectoris and heart attack, than aspirin combined with other statins. In conclusion, statins combined with aspirin have a clear advantage over aspirin alone in preventing CVD. In addition, when various sex, age, and fitness levels were considered, as well as with and without diabetes mellitus, the combination usage of aspirin and rosuvastatin had the greatest CVD preventive effects than aspirin coupled with other statins.
Microbial composition of tumorous and adjacent gastric tissue is associated with prognosis of gastric cancer
Authors: Lehr Konrad , Nikitina Darja , Vilchez-Vargas Ramiro , Steponaitiene Ruta , Thon Cosima , Skieceviciene Jurgita , Schanze Denny , Zenker Martin , Malfertheiner Peter , Kupcinskas Juozas , Link Alexander 
Published: March 2023

AbstractHelicobacter pylori (H. pylori) infection has been considered as the main causal factor in gastric carcinogenesis, but other bacterial species may also play an important role in pathophysiology of gastric cancer. The aim of the study was to explore the link between gastric cancer prognosis and the mucosal microbial community in tumorous and adjacent gastric tissue. The bacterial profile was analysed using 16S sequencing (V1–V2 region). Microbial differences were mostly characterized by lower relative abundances of H. pylori in tumorous gastric tissues. Bacterial community and outcome data analysis revealed the genus Fusobacterium and Prevotella significantly associated with worse overall survival in gastric cancer patients. In particular, Fusobacterium was associated with significant increase in hazard ratio in both univariable and multivariable analysis and independently validated using TCMA data. Phylogenetic biodiversity of Fusobacterium species in the stomach revealed F. periodonticum as the most prevalent in healthy subjects, while F. nucleatum was most abundant in patients with gastric cancer. Bacterial community network analysis in gastric cancer suggests substantial complexity and a strong interplay between F. nucleatum and Prevotella. In summary, mucosal microbial community in the stomach was associated with worse overall survival in gastric cancer patients. Strongest negative impact on prognosis was linked to the abundance of F. nucleatum in tumorous specimens, suggesting its translational relevance in management of gastric cancer patients.
Investigation of Hippo pathway-related prognostic lncRNAs and molecular subtypes in liver hepatocellular carcinoma
Authors: Su Qiongfei , Hua Fengyang , Xiao Wanying , Liu Baoqiu , Wang Dongxia , Qin Xintian 
Published: March 2023

AbstractThis study aimed to investigate Hippo pathway-related prognostic long noncoding RNAs (lncRNAs) and their prognostic value in liver hepatocellular carcinoma (LIHC). Expression and clinical data regarding LIHC were acquired from The Cancer Genome Atlas and European Bioinformatics Institute array databases. Hippo pathway-related lncRNAs and their prognostic value were revealed, followed by molecular subtype investigations. Differences in survival, clinical characteristics, immune cell infiltration, and checkpoint expression between the subtypes were explored. LASSO regression was used to determine the most valuable prognostic lncRNAs, followed by the establishment of a prognostic model. Survival and differential expression analyses were conducted between two groups (high- and low-risk). A total of 313 Hippo pathway-related lncRNAs were identified from LIHC, of which 88 were associated with prognosis, and two molecular subtypes were identified based on their expression patterns. These two subtypes showed significant differences in overall survival, pathological stage and grade, vascular invasion, infiltration abundance of seven immune cells, and expression of several checkpoints, such as CTLA-4 and PD-1/L1 (P < 0.05). LASSO regression identified the six most valuable independent prognostic lncRNAs for establishing a prognosis risk model. Risk scores calculated by the risk model assigned patients into two risk groups with an AUC of 0.913 and 0.731, respectively, indicating that the high-risk group had poor survival. The risk score had an independent prognostic value with an HR of 2.198. In total, 3007 genes were dysregulated between the two risk groups, and the expression of most genes was elevated in the high-risk group, involving the cell cycle and pathways in cancers. Hippo pathway-related lncRNAs could stratify patients for personalized treatment and predict the prognosis of patients with LIHC.
Study on the defect reduction of metal folding on the formed tooth top with finishing roller in gear rolling process
Authors: Fu Xiaobin , Chen Peng , Wang Jiankang , Liu Guangqing , Ma Xiaobao 
Published: March 2023

AbstractCross rolling process is a new method to manufacture large-diameter gears, which has great advantages. While during the gear manufacturing process with cross rolling, due to the difference of deformation mechanism between the right and left formed tooth profiles, a tip is pulled at the tooth top of the workpiece, which severely affects the forming quality. To eliminate the occurred defect, the finishing roller is proposed and designed, the motion equation of the finishing roller is established and solved, the principle of the height increase of the formed tooth is obtained. And also a simplified finite element (FE) model with finishing roller and non-finishing roller are established in the DEFORM-3D software. The comparison of the simulation results between two situations is analyzed and can be concluded that with the finishing roller, the protrusions at both sides of the tooth top of the workpiece at each stage are flattened by the finishing roller, and the accumulation of the tooth top protrusions is not going to occur, which means no extrusion and finishing of the tooth top of the workpiece are required. In addition, the experiment with the finishing roller is carried out and the effectiveness of the finishing roller can be verified.
Relative age effect and performance in elite youth male basketball
Authors: Tascioglu Ramazan , Atalag Ozan , Yuksel Yılmaz , Kocaeksi Serdar , Güven Gülsün , Akyildiz Zeki , Nobari Hadi 
Published: March 2023

AbstractThe aims of the study were to (i) assess the Relative Age Effect (RAE) on elite young male basketball players, (ii) to analyze whether there is a difference between birth quarters (BQ) according to their minutes played and efficiency ratings as individual performance parameters and, (iii) to analyze the relationship between team efficiency, team success, and RAE with a new approach. The research was conducted on 678 players (Age:15.84 ± 0.42) from 53 teams in six different tournaments (from 2014 to 2019). Although, chi-square test showed that more players were born in first BQ than in all other BQs (p < 0.05), no significant difference between BQs and performance measures was found (p > 0.05). However, a relationship between team RAE score, tournament ranking, and team efficiency score was found (p < 0.05). Furthermore, there was a relationship between tournament rankings and team RAE rankings (p < 0.05). While players born in the first months of the year were more likely to be selected for the national youth teams, performance parameters did not show any significant difference when compared to other players who were born later in the same year. However, results showed that teams that have a higher number of athletes who were born in the earlier months of a year showed higher achievement in the tournaments.