bluuebunny/crossref_metadata_2025_split huggingface dataset:
Noncanonical Activity of Tissue Inhibitor of Metalloproteinases 2 (TIMP2) Improves Cognition and Synapse Density in Aging
Authors: Britton Rachel , Wasley Tristan , Harish Reema , Holz Charles , Hall John , Yee Dennis C. , Melton Witt Jody , Booth Elizabeth A. , Braithwaite Steven , Czirr Eva , Kerrisk Campbell Meghan 
Published: June 2023

AbstractPeripheral administration of tissue inhibitor of metalloproteinases 2 (TIMP2), a protein inhibitor of matrix metalloproteinases (MMPs), has previously been shown to have beneficial effects on cognition and neurons in aged mice. Here, to better understand the potential of recombinant TIMP2 proteins, an IgG4Fc fusion protein (TIMP2-hIgG4) was developed to extend the plasma half-life of TIMP2. Following one month of administration of TIMP2 or TIMP2-hIgG4 via intraperitoneal injections, 23-month-old male C57BL/6J mice showed improved hippocampal-dependent memory in a Y-maze, increased hippocampalcfosgene expression, and increased excitatory synapse density in the CA1 and dentate gyrus (DG) of the hippocampus. Thus, fusion to hIgG4 extended the half-life of TIMP2 while retaining the beneficial cognitive and neuronal effects. Moreover, it retained its ability to cross the blood-brain barrier. To deepen the mechanistic understanding of the beneficial function of TIMP2 on neuronal activity and cognition, a TIMP2 construct lacking MMP inhibitory activity, Ala-TIMP2, was generated, which provides steric hindrance that prevents inhibition of MMPs by the TIMP2 protein while still allowing MMP binding. A comprehensive assessment of the MMP inhibitory and binding capacity of these engineered proteins is outlined. Surprisingly, MMP inhibition by TIMP2 was not essential for its beneficial effects on cognition and neuronal function. These findings both confirm previously published research, expand on the potential mechanism for the beneficial effects of TIMP2, and provide important details for a therapeutic path forward for TIMP2 recombinant proteins in aging-related cognitive decline.
Involvement of oxidative stress in placental dysfunction, the pathophysiology of fetal death and pregnancy disorders
Authors: Sultana Zakia , Qiao Yixue , Maiti Kaushik , Smith Roger 
Published: June 2023

In brief
Placental oxidative stress contributes to both normal and abnormal placentation during pregnancy. This review discusses the potential consequence of oxidative stress-induced placental dysfunction on pregnancies complicated by fetal death and pregnancies with a high risk of fetal death.

Abstract
The placenta is a source of reactive oxygen free radicals due to the oxidative metabolism required to meet the demands of the growing fetus. The placenta has an array of efficient antioxidant defense systems to deal with rising oxidative stress created by free radicals during pregnancy. Properly controlled physiological (low-level) free radical production is a necessary part of cellular signaling pathways and downstream activities during normal placental development; however, poorly controlled oxidative stress can cause aberrant placentation, immune disturbances and placental dysfunction. Abnormal placental function and immune disturbances are linked to many pregnancy-related disorders, including early and recurrent pregnancy loss, fetal death, spontaneous preterm birth, preeclampsia and fetal growth restriction. This review discusses the role of placental oxidative stress in both normal and pathological settings. Finally, based on previously published work, this review presents multiple lines of evidence for the strong association between oxidative stress and adverse pregnancy outcomes, including fetal death and pregnancies with a high risk of fetal death.
Sesgos de género en la interpretación de los restos óseos humanos. Sex, gender and sexuality biases in the interpretation of skeletal human remains
Authors: Higuero Antonio 
Published: June 2023

Nuestra concepción actual y occidental sobre el sexo y el género como dicotómicos e inmutables, y de las relaciones sexuales entre hombre y mujer como monógamas y solamente con fin reproductor, afectan a la manera sobre como interpretamos el pasado y las narrativas que construimos de él a través de los restos óseos encontrados en excavaciones arqueológicas y paleoantropológicas. Este bodyscape biomédico aplicado destemporaliza estos restos y sirve, en un argumento circular, para justificar conductas y discursos presentes. A través de una serie de ejemplos se observa cómo actúa, su efecto y se propone la aplicación de teorías alternativas sobre el sexo, el género y la sexualidad con el fin de ampliar las perspectivas a la hora de interpretar el pasado. ABSTRACTOur current and occidental conceptions about sex and gender as dichotomic and immutable, and about sexual relations between a man and a woman as monogamous and only with reproductive purposes, affect the way we are interpreting the past and the narratives we build of it through the analysis of human remains from the archaeological and palaeoanthropological record. This applied biomedical bodyscape destemporalizes those remains and serves, in a circular argument, to justify current behaviours and discourses. Through a series of examples is shown how if performs, its effect, and other alternative theories about sex, gender and sexuallity are proposed with the goal of broaden our perspectives when interpreting the past.
«Las mujeres y las guerras»: aspectos de una temática heterogénea. «Women and wars»: aspects of an heterogeneous subject
Authors: Tavera Susanna 
Published: June 2023

Este artículo revisa la descoordinación historiográfica con que todavía se plantea el convencimiento de que «las mujeres dan la vida» y de que, por tanto, la «naturaleza femenina aborrece la guerra» y, con ella, las armas o su probada y creciente capacidad destructiva. Pretende probar que el epígrafe «mujeres y guerras» remite a una temática muy compleja y que no debieran confundirse, primero, las implicaciones que en el mundo contemporáneo tienen las relaciones entre mujeres y violencia y, segundo, que existen importantes diferencias entre la movilización militante y las relaciones de las mujeres con las instituciones armadas o la llamada militarización. Se contempla el tema desde esta triple distinción y evita simplificaciones como la de las guerras han transformado «las relaciones entre sexos y les han dado de manera estable «poderes nuevos» a las mujeres, por ejemplo, durante la Primera Guerra Mundial o la Guerra Civil española.Palabras clave: Militarización, movilización, movilización militante, mujeres y guerras, mujeres y Primera Guerra Mundial, mujeres y Guerra Civil Española, género y guerras contemporáneas.AbstractThis article wants to verify the lack of historiographical co-ordination showed in the conviction that «women give life» and that consequently women have hated war, weapons and its growing destructive capacity. It wants to prove that «women and war» is a very complex subject that shouldn’t confuse the implications war violence have had for women in contemporary times. It wants to clarify the decisive arguments that any political and historical analysis shows in relation with feminine militant movilitacion and women militarization. From this last twofold distinction is possible to scape simplifications as that wars have given stable and new powers to women, for example during the I World War and during the Spanish Civil War. Keywords: Militaritation, mobilisation, militant mobilisation, women and wars, women and First World War, women and Spanish Civil War, gender and contemporary wars.
Batallar fuera de casa: mujeres de uniforme en la Primera Guerra Mundial. Battling out of the Home Front: Women in Uniform During World War One
Authors: Huguet Montserrat 
Published: June 2023

En el otoño de 1914 las mujeres de los países occidentales dieron el paso de afrontar la guerra y tomar parte activa en ella. Lo hicieron a la manera diversa en que los seres humanos afrontan los problemas: en la difícil cotidianidad del que aguarda el regreso de los soldados, soportando todo el esfuerzo del sostenimiento familiar, o colaborando en los trabajos de producción para la vida civil y militar. Pero no pocas empujaron a los gobiernos para que les permitieran luchar dentro de los ejércitos, llevando los uniformes militares y mostrando los colores de la patria. Estas líneas están dedicadas a conformar su historia.Palabras clave: Primera Guerra Mundial, mujeres, ejércitos.AbstractIn the fall of 1914 western women began their way to cope with war taking an active part in it. They did it in the various ways human beings usually face problems: awaiting the return of the soldiers in the everyday difficulties, supporting all the works of family´s needs, or helping in the country production work for the civil and military life. But also, not few women pushed governments to allow them fighting in armies, wearing military uniforms and showing the colors of their country. This text shows their history.Keywords: First World War, women, armies.
[ES] REFORMISMO BORBÓNICO Y CONTESTACIÓN SOCIAL: LA ERECCIÓN DEL MONOPOLIO DE TABACO EN LA HABANA (1717-1723) // BOURBON REFORMISM AND SOCIAL OPPOSITION: THE ESTABLISHMENT OF TOBACO MONOPOLY IN HAVANA
Authors: Hernández González Manuel 
Published: June 2023

Este artículo estudia la respuesta del conjunto de la sociedad cubana y especialmente del campesinado tabaquero frente al monopolio de la comercialización del tabaco desarrollado por el reformismo borbónico. Aborda tres rebeliones populares en La Habana entre 1717 y 1723 con resultado dispar desde la expulsión del gobernador en la primera a la cruenta represión de la tercera. Una represión que culminó con un pacto entre las elites y la Monarquía en prejuicio de los pequeños cultivadores.PALABRAS CLAVE: Historia de Cuba, Historia del Caribe, rebeliones campesinas, reformismo borbónico, tabaco, migraciones, cambio social. --This article studies the response of the entire Cuban society and especially the peasantry against the tobacco monopoly marketing snuff developed by Bourbon reformism. It addresses three popular rebellions in Havana between 1717 and 1723 with mixed results from the expulsion of the first governor in the bloody repression of the third. A rebellion that culminated in a pact between the elites and the monarchy to the detriment of small farmers. KEY WORDS: History of Cuba, Caribbean history, peasant rebellions, bourbon reformism, Snuff, migration, social change.
Seismological studies at Parkfield. I. Simultaneous inversion for velocity structure and hypocenters using cubic B-splines parameterization
Authors: Michelini A. , McEvilly T. V. 
Published: June 2023

Abstract
A model for the 3D P- and S-wave velocity structure at Parkfield has been developed by the systematic inversion of arrival times for microearthquakes and surface Vibroseis sources, recorded by nearby CALNET stations and by the local borehole-installed 10-station High-Resolution Seismic Network there. A modification of the linear B-splines model parameterization method of Thurber (1983) to a cubic B-splines formulation, through tests inverting synthetic data sets for the Parkfield configuration, is found to produce smooth velocity distributions that still retain some small-scale features. Application of the method to 953 P-wave and 288 S-wave arrivals from 111 microearthquakes and 8 Vibroseis locations throughout the study area yields a velocity structure having variable resolution. A low-velocity zone appears to coincide with the creeping segment of the San Andreas fault zone northwest of the 1966 Parkfield earthquake epicenter. An increase of about 15 per cent in seismic velocities is seen from the northeast to southwest across this segment of the fault zone. The higher velocities to the southwest apparently correspond to the granitic basement. The contrast across the fault is subdued to the southeast along the 1966 rupture zone. A high Vp/Vs ratio of 1.9 is seen in a 2-km-wide volume near the location of the 1966 main shock hypocenter, presumably the nucleation zone for the expected M = 6 Parkfield earthquake.
Indagaciones sobre mentoría virtual en estudios doctorales. Una revisión apoyada en la heurística decisional para la selección del mentor
Authors: Márquez Rondón Gerardo Antonio , Pérez María Auxiliadora 
Published: June 2023

El objetivo del artículo es indagar sobre la heurística decisional, utilizada por los estudiantes de doctorado en gerencia en tres universidades venezolanas, para la elección de un mentor en el contexto de un proceso de mentoría virtual. Teóricamente se trata de una investigación basada en el paradigma bimodal de la educación por Internet, articulada y enfocada desde el paradigma fenomenológico interpretativo. Metodológicamente se trata una investigación exploratoria y cualitativa, en la que se aplicó para la recolección de la información entrevistas enfocadas en las percepciones de los estudiantes en relación a las cualidades del ser, saber y hacer valoradas en el mentor. Los resultados develaron que la relación mentor-aprendiz en el proceso de mentoría virtual, se edifica sobre cuatro heurísticos fundamentales: la empatía, la dedicación, la coherencia y la integralidad. Se puede concluir que lo que conforma una aproximación empírica a las cualidades del mentor virtual que los aprendices requieren para aprender los procesos de producción científica doctoral con éxito. Por tanto, se propone que estos heurísticos deben ser desarrollados por ellos para generar confianza en el estudiante. Este trabajo incentiva a los mentores a desarrollar los rasgos identificados en la formación académica, de cara a aumentar la calidad de los procesos de formación doctoral.
Manajemen Pengorganisasian Unit Kegiatan Mahasiswa (UKM) An-Nadi Belajar Bahasa Arab UIN Mataram
Authors: Heryadi M. , Hilmi Danial 
Published: June 2023

Penelitian ini membahas mengenai manajemen pengorganisasian unit kegiatan mahasiswa (UKM) An-nadi lita’allumil lughatul arabiyah universitas islam negeri Mataram dan bagaimana pembagian tugas di UKM tersebut. Penelitian ini menggunakan metode penelitian kualitatif bersifat deskriptif . Pengumpulan data digunakan dengan menggunakan teknik wawancara dengan Ra’is ‘Amm (ketua umum) An-nadi dan dokumentasi. Setelah data terkumpul dilakukan analisis data dengan: 1) reduksi data, 2) penyajian data, 3) penarikan kesimpulan. Dari penelitian ini dapat diketahui bahwa sistem pengorganisasian di UKM An-nadi sudah baik karena memiliki struktur organisasi yang jelas. Pembagian kerja atau tugas kepada anggota secara jelas dan tertulis sehingga anggota dalam menjalankan program sesuai dengan bidang dan jobnya masing-masing.
The Rapid Learning Shift In The Time Of Covid-19: Exploring The Efl Learners’ Speaking Anxiety
Authors: Sandiarsa K. Dedy , Bagis Abdul Kadir , Sumarsono Dedi 
Published: June 2023

The rapid learning shift due to the existence of Covid-19 was mandatory to be conducted at school. Due to this matter, the teaching and learning approach has been shifted from having face-to-face interaction in the classroom to distance learning and to the mixture between face-to-face interaction and distance learning. The goal of the research was to figure out the EFL learners’ anxiety due to the rapid shift learning in this covid-19 pandemic. This study was conducted at second grade students of SMAN 8 Mataram. The finding shows that a high level of anxiety of the EFL learners’ contribute to the students speaking performance. When building communication with others, the EFL learners speaking skill were not performed well due to their high speaking anxiety. The main causes of the EFL learners anxiety were lack of confidence, fear of making mistakes, lack of practice, and low speaking skill level.
The Use of Cooperative Integrated Reading and Composition (CIRC) to Improve the Students’ Reading Comprehension
Authors: Muhsinin  , Rahmat Hery , Khusniyah Nurul Lailatul 
Published: June 2023

In general, most of the students of seventh grade have difficulties in comprehending texts. The objective of this research is to investigate whether the Cooperative Integrated Reading and Composition (CIRC), can improve the students’ reading comprehension at a junior high school in East Lombok Regency. The participants of this research were 25 students. This research was classroom action research which was done in two cycles. The data of this research were collected by conducting observation, test, and documentation, with the criteria of minimum mastery (KKM) of 75. There were two kinds of activities observed namely the teacher’s activity and the students’ activity. The students’ ability was measured by using comprehension test. The result showed that the students successfully met the criteria of minimum mastery. It was indicated from the improvement of the students’ mean score from 67 in Cycle 1 to 81 in Cycle 2. Moreover, the teaching activities improve from 74 in cycle 1 to 94 in cycle 2. Furthermore, the students’ activity also improves from 47 in cycle 1 to 84 in cycle 2. In conclusion, CIRC method was found beneficial to improve the students’ reading comprehension, and to enhance the teaching learning process of reading.
Thurq Tadris Maharaat Al-Lughah Al-"Arabiyah: Al-Qiro'ah Walkitabah Namuzujan
Authors: Balbakay Djamel , Otmane Safa , Ghonam Ibtisam Dukturah 
Published: June 2023

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Ta’lim al-Lughah al-‘’Arabiyah li I’dad al-Mu’allimin wa al-Du’at Tajribah Jami’ah ‘Ali bin Abi Talib Surabaya Indunisiya
Authors: Jauhar Nasaruddin Idris 
Published: June 2023

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GENEALOGI ISLAM NUSANTARA DI LOMBOK DAN DIALEKTIKA AKULTURASI BUDAYA: WAJAH SOSIAL ISLAM SASAK
Authors: Mutawali Mutawali , Zuhdi Muhammad Harfin 
Published: June 2023

Artikel ini bertujuan memaparkan tentang genealogi jaringan Islam Nusantara di gumi Sasak Lombok. Bahwa jalur tranasmisi dakwah Islam ke Lombok berasal dari pulau Jawa melalui dakwah para Wali. Penyebaran Islam di pulau Lombok berlangsung dengan penuh kedamaian, tanpa unsur paksaan, kekerasan, maupun peperangan.Kegiatan dakwah Islam di pulau Lombokditunjang dengan mobilitas fisik atau migrasi para Wali dari Jawa ke Lombok. Menurut data babad, tradisi lisan masyarakat Lombok dan penuturan para narasumber bahwa Islam masuk dan berkembang di pulau Lombok terjadi pada abad ke-16 yang dibawa oleh Pangeran Prapen (1548-1605) yang dikenal jugadengan Sunan Giri keempat.Peranan Pangeran Prapen dalam menyebarkan agama Islam di pulau ini sangat besar sekaligus membawa nuansa pertukaran budaya Jawa dan Lombok berlangsung sepanjang abad ke-16 dan ke-17.Warna Islam yang dibawa dari Jawa ini adalah berciri sufisme-sinkretik. Islam dipulau Lombok merupakan salah satu jaringan varian Islam Nusantara setelah terjadinya dialektika antara Islam dengan budaya Sasak Lombok. Proses dialektika tersebut pada gilirannya menghasilkan Islam yang unik, khas, dan esoterik, dengan beragam tradisi-tradisi Sasak yang sudah disisipi nilai-nilaiIslam. Pada perkembangan selanjutnya, Islam dan tradisi Sasak menjadi satu kesatuan yang tidak dapat dipisahkan meski masih dapat dibedakan satu sama lain.
Strategi Permintaan Maaf dalam Klarifikasi Figur Publik kepada Masyarakat di Media Sosial
Authors: Chintawidy Permas Adinda 
Published: June 2023

Penelitian ini bertujuan untuk menganalisis penggunaan tindak tutur permintaan maaf dalam klarifikasi yang disampaikan figur publik melalui media sosial kepada masyarakat berdasarkan model strategi Cohen dan Olshtain (1981). Strategi yang digunakan kemudian dihubungkan dengan konteks sosial yang dipengaruhi oleh status sosial para figur publik sesuai dengan teori kesantunan Brown & Levinson (1987) yaitu kekuatan sosial, jarak sosial, dan beratnya pelanggaran. Sumber data penelitian ini adalah unggahan permintaan maaf melalui takarir pada akun Instagram pribadi beberapa figur publik dalam ranah industri hiburan Indonesia sejak bulan sejak Januari hingga Juni 2022. Adapun figur publik yang dimaksud adalah IK, OSD, dan DC. Hasil penelitian menunjukkan bahwa terdapat tiga dari enam jenis strategi yang paling banyak digunakan oleh para figur publik, yaitu permintaan maaf langsung, permintaan maaf tidak langsung dalam bentuk memberikan penjelasan, dan permintaan maaf tidak langsung dalam bentuk menawarkan perbaikan. Selain itu, terdapat pula perbedaan status sosial berupa achieved status yang dimiliki para figur publik jika dibandingkan dengan masyarakat pada umumnya. Akibatnya, ketika dihubungkan dengan tingkat kesantunan berdasarkan kekuatan sosial, dapat disimpulkan bahwa figur publik cenderung tidak menggunakan jenis strategi yang beragam saat meminta maaf kepada masyarakat dalam media sosial.

Kata-kata kunci: klarifikasi, permintaan maaf, figur publik, konteks sosial, Instagram