bluuebunny/crossref_metadata_2025_split huggingface dataset:
Overnight response to levetiracetam in Lance–Adams syndrome presenting 3 years after cardiac arrest
Authors: AbdelRazek Mahmoud A. , Marey Ahmed , Taha Ahmed , Morin Scott J. , Brodski Alexander , Mollashahi Roohallah S. 
Published: August 2023

AbstractBackgroundLance–Adams syndrome (LAS), also known as chronic post-hypoxic myoclonus manifests as myoclonic movements of the face, limbs, or trunk following hypoxic brain injury, which may occur during respiratory failure or cardiac arrest.Case presentationWe present a case and provide a video of a patient who developed LAS 3 years after experiencing cardiac arrest, presenting with action-induced generalized myoclonus upon standing. The patient exhibited a significant response to levetiracetam. To the best of our knowledge, this is the first reported case of LAS with such a delayed onset following the initial hypoxic event.ConclusionIt is crucial for clinicians to be aware of this treatable condition and recognize that its onset may be delayed, occurring years after a hypoxic brain insult. This improved understanding will facilitate prompt diagnosis and effective management of LAS, ultimately enhancing patient outcomes.
Does post-acute COVID-19 syndrome women's sex problems link to psychiatry after 6 months?
Authors: Shehata Rofaida Refaat , Ahmed Gellan K. , Hussien Aliae A. R. Mohamed , Mahmoud Manal A. 
Published: August 2023

Abstract
Background
Few data about women's sexuality practices post-acute COVID-19 syndrome are available. Many women who have had the disease experience sexual dysfunction; hence, the adverse effect of COVID-19 on sexual function has generated interest. We aimed to clarify the impact of COVID-19 on female sexual function 6 months after the illness and possible risk factors and to evaluate the relationship between psychiatric problems and female sexual dysfunction 6 months after COVID-19. Sixty-two patients were enrolled in this cross-sectional study and assigned according to female sexual function index scores to two groups: those with and without sexual dysfunction. For all participants, we documented socioeconomic status, sexual history, symptoms of COVID-19, vaccination data, and Symptom Checklist 90.

Results
Sexual dysfunction was 58% of all participants after 6 months COVID-19. Sexual frequency and sexual problems except pain were decreased in both groups with more affection in sexual dysfunction women. Sexually dysfunctional women were more likely to obtain oxygen therapy during COVID-19, received AstraZeneca, had post-vaccination myalgia and headache, and recurring COVID-19 after vaccination. No significant SCL-90 subscale differences. Sexual dysfunction was associated with renal illness, fatigue, COVID-19-related oxygen therapy, post-vaccination myalgia, and headache.

Conclusions
After 6 months COVID-19, there was a decline in the frequency of sexual intercourse and scores on all FST subscales in both groups except pain, with more affection in sexual dysfunction women. No statistical difference in psychiatric problems between both groups. Sexual dysfunction was associated with renal illness, COVID-19-related oxygen therapy and fatigue, post-COVID-19-vaccination myalgia, and headache.
Computational Approach for Molecular Design of Small Organic Molecules with High Hole Mobilities in Amorphous Phase Using Random Forest Technique and Computer Simulation Method
Authors: Nakaguro Keijin , Mitsuta Yuki , Koseki Shiro , Oshiyama Tomohiro , Asada Toshio 
Published: August 2023

Abstract
A molecular design system of small organic molecules was developed to realize high hole mobility in the amorphous phase by using the random forest (RF) technique and a computer simulation method. Since there was no accessible datasets of the hole mobilities in the amorphous phase, we have constructed a datasets of experimental hole mobilities for 321 organic molecules with calculated MO energies to utilize machine learning techniques for molecular design procedures. RF was applied to the machine learning technique using the constructed datasets. The optimized RF exhibited correlation coefficients of 0.885 and 0.764 for the training and testing datasets, respectively. The modified ChemTS to use optimized RF was adapted to design molecules with high hole mobilities. The successive conduction (SC) model that uses ab initio molecular orbital (MO) calculations and the Marcus theory was adapted to ensure the predicted mobilities. The generated molecules were verified to have high calculated hole mobility (the order of 10−2 cm2/Vs) owing to the highest transfer integral and lowest reorganization energy by the theoretical successive conduction (SC) model. The datasets and programs used in this work were publicly released on GitHub.
A protocol for a systematic review of standardised tools used in perinatal death review programmes
Authors: O'Connor Emily , Greene Richard , O'Donoghue Keelin , Leitao Sara 
Published: August 2023

Introduction: Perinatal mortality encompasses stillbirths and early neonatal deaths. A perinatal death surveillance and response cycle has been recommended by the World Health Organization for use in the review of perinatal deaths. The main components of the cycle include identifying and reporting perinatal deaths, and reviewing the deaths, including potentially modifiable factors, in order to measure and improve quality of care provided to women and infants. There is no consensus on the best way to design, implement and conduct perinatal death reviews. This systematic review aims to identify standardised tools that are used to review perinatal deaths. Objectives: The primary aim of this protocol is to describe methodology for a systematic search of the literature to identify standardised tools that are used to review perinatal deaths in upper-middle to high-income countries. Review tools may include standardised checklists, forms, frameworks or other structured documents used to review perinatal deaths. Review tools will be appraised to see if they incorporate the identification of modifiable factors in perinatal deaths and establish recommendations for improvements to quality of care provided. Methods: A systematic review of the literature will be performed to identify peer-reviewed publications and grey literature describing the use of perinatal mortality review tools without date restrictions. The eligibility of review tools for inclusion will be based on inclusion and exclusion criteria applied to the SPIDER framework. Data will be extracted based on the structure and content of included review tools, and the tools will be appraised using the Appraisal of Guidelines Research and Evaluation Health Systems (AGREE-HS) instrument. Conclusion: This systematic review protocol for identifying and appraising standardised perinatal mortality review tools may help to establish the optimal way to structure a standardised review process for perinatal mortality in middle- to high-income countries. PROSPERO registration: CRD42022326877
Automation of Strategic Data Prioritization in System Model Calibration: Sensor Placement
Authors: Li Tianyi , Dahleh Munther A. 
Published: August 2023

Model calibration is challenging for large-scale system models with a great number of variables. Existing approaches to partitioning system models and prioritizing data acquisition rely on heuristics rather than formal treatments. The sensor placement problem in physical dynamic systems points to a promising avenue for formalizing data acquisition priorities, which addresses the following question for system models: With the model at hand and pre-existing data availability on a subset of model variables, what are the (next) k model variables that would bring the largest utility to model calibration, once their data are acquired? In this study, we formalize this problem as a combinatorial optimization and adapt two solutions, the information-entropy approach and the miss-probability approach, from physical dynamic systems to system models in management sciences. Next, based on the idea of the data availability partition, we develop a third solution. The new approach can be understood from the entropy perspective and is embedded in the theoretical framework for the evaluation of side information. Our solution applies to system models of all topologies: analytical results of the optimal placement are derived for binary/multinary trees; for general (directed) tree structures, an algorithm to determine the optimal placement is devised, whose complexity is upper-bounded by [Formula: see text] for an n-variable system; for arbitrary model topologies with the presence of loops, sequential-optimal and simulated-annealing schemes are formulated. Three approaches are compared on a validating example; our solution outperforms the two alternatives. Application on a multicompartment system demonstrates the toolkit’s practical use. History: Accepted by Pascal Van Hentenryck, Area Editor for Computational Modeling: Methods & Analysis. Supplemental Material: The software that supports the findings of this study is available within the paper and its Supplemental Information ( https://pubsonline.informs.org/doi/suppl/10.1287/ijoc.2022.0128 ) as well as from the IJOC GitHub software repository ( https://github.com/INFORMSJoC/2022.0128 ). The complete IJOC Software and Data Repository is available at https://informsjoc.github.io/ .
Demographic “Stickiness”: The Demographic Identity of Departing Group Members Influences Who Is Chosen to Replace Them
Authors: Chang Edward H. , Kirgios Erika L. 
Published: August 2023

People tasked with replacing a departing group member are disproportionately likely to choose a replacement with the same demographic identity, leading to demographic “stickiness” in group composition. We examine this effect in 2,163 U.S. federal judge appointments over 75 years, in the selection of 5,616 S&P 1500 board directors from 2014 to 2019, and in four preregistered experiments (n = 2,900). The patterns we document are generally consistent with both impact aversion (desires to minimize changes to group composition and dynamics) and diversity loss aversion (outsized concerns about losing ground on demographic diversity relative to interests in gaining ground). Ultimately, our results suggest that replacement decisions are influenced by loss-averse preferences regarding the demographic identities of departing group members. The propensity to choose new group members based on whether they demographically resemble their predecessors suggests that once progress toward diversification has occurred, it should be “sticky,” so backsliding is less likely than might otherwise be expected. An optimistic outlook is that one-time interventions to change group composition may have a lasting impact, and change agents committed to diversification may have enduring effects on equality beyond their tenure. This paper was accepted by Yuval Rottenstreich, behavioral economics and decision analysis. Supplemental Material: The data files and online supplement are available at https://doi.org/10.1287/mnsc.2023.4897 .
“I will never wish this pain to even my worst enemy”: Lived experiences of pain associated with manual vacuum aspiration during post-abortion care in Kenya
Authors: Ouedraogo Ramatou , Obure Valleria , Kimemia Grace , Achieng Anne , Kadzo Mercy , Shirima Jane , Dama Shilla Unda , Wanjiru Shelmith , Both Jonna 
Published: August 2023

Background and objectives
In Kenya, where abortion is legally restricted, most abortions are induced using unsafe procedures, and lead to complications treated in public health facilities. The introduction of Manual Vacuum Aspiration (MVA) to treat incomplete abortion has improved the management of abortion complications. However, this technology comes with pain whose management has been a challenge. This paper explores the lived experiences of pain (management) during MVA to document the contributing factors.

Methods
We used an ethnographic approach to explore girls and healthcare providers’ experiences in offering and accessing post-abortion care in Kilifi County, Kenya. The data collection approach included participant observation and informal conversations in public health facilities and neighboring communities, as well as in-depth interviews with 21 girls and young women treated for abortion complication and 12 healthcare providers.

Results
Our findings show that almost all patients described the MVA as the most painful procedure they have ever experienced. The unbearable pain was explained by various factors, including the lack of preparedness of health facilities to offer PAC services (i.e. lack of pain medicine, lack of training, inadequate knowledge and grasp of pain medication guidelines, and malfunctioning MVA kits). Moreover, the attitudes of healthcare providers and facilities management toward the MVA device limited the supply and replacement of MVA kits. Moreover, the scarcity of pain medicines also gave some providers the opportunity to abuse patients guided by their values, whereby they would deny patients pain medication as a form of "punishment" if they were suspected of inducing their abortion, especially adolescent girls.

Conclusion
The study findings suggest the need for clearer guidelines on pain medication, value clarification and attitude transformation training for providers, systematizing the use of medical uterine evacuation using medical abortion drug and strengthening the supply chain of pain medication and MVA kits to reduce the pain and improve the quality of post-abortion care.
Late-stage presentation with decompensated cirrhosis is alarmingly common but successful etiologic therapy allows for favorable clinical outcomes
Authors: Schwarz Michael , Schwarz Caroline , Burghart Lukas , Pfisterer Nikolaus , Bauer David , Hübl Wolfgang , Mandorfer Mattias , Gschwantler Michael , Reiberger Thomas 
Published: August 2023

Introduction
Liver cirrhosis accounts for considerable morbidity and mortality worldwide and late presentation limits therapeutic options. We aimed to assess characteristics of patients with liver cirrhosis at the time of first presentation and during their clinical course.

Methods
Patients with cirrhosis as evident by presence of varices at endoscopy, liver stiffness ≥15kPa at elastography, or ascites requiring paracentesis between Q1/2015-Q2/2020 were retrospectively included. Clinical, laboratory, and imaging data were collected from medical records at presentation and last follow-up.

Results
476 patients were included (alcohol-related liver disease, ALD: 211, 44.3%; viral hepatitis: 163, 34.2%). Of these, 106 patients (22.3%) and 160 patients (33.6%) presented already with Child-Pugh C and MELD >15, respectively, and decompensation events were registered in 50% (238 patients) at baseline, and even in 75.4% of ALD patients.
During a median follow-up of 11.0 (IQR 4–24) months, 116 patients died. Two-year survival was worse for patients with ALD than for viral hepatitis (71.1% vs. 90.2%, log rank p<0.001). We observed the highest percentage of portal-vein thrombosis (30.0%), hepatocellular carcinoma (15.0%), and death (45.0%) in the MAFLD group (n = 20). Patients cured from hepatitis C showed significant improvements in platelet count (147 to 169 G/L, p<0.001) and liver stiffness (26.2 to 17.7 kPa, p<0.001), while ALD patients improved in Child-Pugh score (8.6 to 7.6, p<0.001) during follow-up. With increasing Child Pugh score and MELD, we found increasing serum concentrations of CRP (p<0.001) and an inverse correlation with serum HDL (Spearman’s ρ = -0.573 and -0.529, respectively, p<0.001).

Conclusion
Half of the patients with cirrhosis had decompensated cirrhosis at presentation. This calls for increased awareness and strategies for earlier diagnosis of chronic liver disease and cirrhosis.
Genetic and antiretroviral drug resistance mutations analysis of reverse transcriptase and protease gene from Pakistani people living with HIV-1
Authors: Siddiqui Dilsha , Badar Uzma , Javaid Mahnoor , Farooqui Nida , Shah Sharaf Ali , Iftikhar Ayesha , Sultan Faisal , Mir Fatima , Furqan Sofia , Mahmood Syed Faisal , Abidi Syed Hani 
Published: August 2023

Background
Antiretroviral therapy (ART) effectiveness is compromised by the emergence of HIV drug resistance mutations (DRM) and can lead to the failure of ART. Apart from intrinsic viral factors, non-compliance with drugs and/or the use of sub-optimum therapy can lead to the emergence of DRMs. In Pakistan HIV currently exists as a concentrated epidemic, however, ART coverage is very low, and drug adherence is poor. ART is selected assuming without baseline genotyping. Pakistan has recently seen a rise in treatment failures, but the country’s actual burden of DRM is still unknown. In this study, we perform the genetic and drug resistance analysis of the pol gene from Pakistani HIV-positive ART-naïve and ART-experienced individuals.

Methods
In this study, HIV-1 pol was sequenced from 146 HIV-1 positive individuals, divided into ART-naïve (n = 37) and ART-experienced (n = 109). The sequences were also used to determine HIV-1 subtypes, the prevalence of DRM, and pol genetic variability.

Results
DRM analysis identified numerous DRMs against reverse transcriptase inhibitors in both ART-naïve and ART-experienced groups, including a few that are classified as rare. Additionally, the ART-experienced group showed mutations associated with resistance to protease inhibitors. Genetic analysis showed negative selection pressure in both groups, but a higher rate of evolution in the ART-naïve group.

Conclusion
High prevalence of DRMs, especially against previous first-line treatment in ART- naïve and the accumulation of DRMs in ART-experienced groups is concerning and warrants that a more extensive DRM survey be carried out to inform first-line and second-line ART regimen recommendations.
P.Cair.Zen. IV 59538: An Autograph Letter by Amyntas (With a Study on Amyntas’ Handwriting Style)
Authors: Frutos García Alba de 
Published: August 2023

Abstract
P.Cair.Zen. IV 59538 (TM 1174), dated to 16 January of 257 BCE, is a fragmentary papyrus from the Zenon Archive that preserves the final part of a letter. Along with a significant part of its content, the identity of both its sender and addressee has been lost. However, a careful analysis of the material aspects of the letter reveals that its author and scribe can be identified with Amyntas (TM Per 769), the administrator of the Alexandrine household of Apollonios.
A Name List on Claudius’s Letter to the Alexandrians (P.Lond. VI 1912)
Authors: Blumell Lincoln H. 
Published: August 2023

Abstract
The publication of a list of names that appears between columns two and three of Claudius’s letter to the Alexandrians (P.Lond. VI 1912). Though the hand of the list is different from the hand of the letter, it shares paleographic and onomastic parallels with other documents in the archive of Nemesion.
Analysis of online assignments designed by chemistry teachers based on their knowledge and self-regulation
Authors: Hadas Boaz , Herscovitz Orit , Dori Yehudit Judy 
Published: August 2023

Abstract
Learners’ independence and self-regulated learning (SRL) may be achieved by online teaching, promoting learners’ 21st century skills. Transitioning into online learning and teaching requires a variety of teachers’ knowledge types and competencies. Mapping these knowledge types with a dedicated tool can help improve teachers’ professional development processes to enhance the SRL of teachers and subsequently students. We aimed at investigating the types of knowledge chemistry teachers expressed in online assignments they had designed, which included guidelines to foster their students’ SRL, and reviewing their reflections upon implementing these assignments. The participants were 20 high school chemistry teachers, who took part in two professional development programs focusing on fostering students’ SRL skills in online assignments, the teachers had designed. Research tools included teachers’ online assignments and teachers’ written reflections. We analyzed the assignments using a special rubric, which consists of three types of teachers’ knowledge: technological pedagogical and content knowledge (TPACK), assessment knowledge (AK), and SRL. Findings show that the analysis rubric of online assignments, designed by teachers, enabled identifying various teacher knowledge types and their levels. The use of a validated rubric for mapping and assessing teachers’ knowledge types is a methodical contribution to research on chemistry teachers’ professional development.
Categories of modules, comodules and contramodules over representations
Authors: Balodi Mamta , Banerjee Abhishek , Ray Samarpita 
Published: August 2023

Abstract
We study and relate categories of modules, comodules and contramodules over a representation of a small category taking values in (co)algebras, in a manner similar to modules over a ringed space. As a result, we obtain a categorical framework which incorporates all adjoint functors between these categories in a natural manner. Various classical properties of coalgebras and their morphisms arise naturally within this theory. We also consider cartesian objects in each of these categories, which may be viewed as counterparts of quasi-coherent sheaves over a scheme. We study their categorical properties using cardinality arguments. Our focus is on generators for these categories and on Grothendieck categories, because the latter may be treated as replacements for noncommutative spaces.
On some inequalities for numerical radius of semi-Hilbert space multioperators
Authors: Guesba Messaoud , Mahmoud Sid Ahmed Ould Ahmed 
Published: August 2023

Abstract
In this paper, we aim to introduce new inequalities of the m-tuples of
semi-Hilbert space operators. These inequalities, which are based on some numerical radius inequalities due to Dragomir et al. for a single operator on a Hilbert space. Further, we give a new formula of the A-Euclidean operator
semi-norm of m-tuples of operators on a semi-Hilbert space.
On the characterization of generalized (m, n)-Jordan *-derivations in prime rings
Authors: Siddeeque Mohammad Aslam , Shikeh Abbas Hussain 
Published: August 2023

Abstract
Let

𝒜

{\mathcal{A}}

be a prime ring equipped with an involution ‘

*

{*}

’ of order 2 and let

m
≠
n

{m\neq n}

be some fixed positive integers such that

𝒜

{\mathcal{A}}

is

2
⁢
m
⁢
n
⁢

(

m
+
n

)

⁢

|

m
-
n

|

{2mn(m+n)|m-n|}

-torsion free. Let

𝒬

m
⁢
s

⁢

(
𝒜
)

{\mathcal{Q}_{ms}(\mathcal{A})}

be the maximal symmetric ring of quotients of

𝒜

{\mathcal{A}}

and consider the mappings

ℱ

{\mathcal{F}}

and

𝒢
:

𝒜
→

𝒬

m
⁢
s

⁢

(
𝒜
)

{\mathcal{G}:\mathcal{A}\to\mathcal{Q}_{ms}(\mathcal{A})}

satisfying the relations

(

m
+
n

)

⁢
ℱ
⁢

(

a
2

)

=

2
⁢
m
⁢
ℱ
⁢

(
a
)

⁢

a
*

+

2
⁢
n
⁢
a
⁢
ℱ
⁢

(
a
)

(m+n)\mathcal{F}(a^{2})=2m\mathcal{F}(a)a^{*}+2na\mathcal{F}(a)

and

(

m
+
n

)

⁢
𝒢
⁢

(

a
2

)

=

2
⁢
m
⁢
𝒢
⁢

(
a
)

⁢

a
*

+

2
⁢
n
⁢
a
⁢
ℱ
⁢

(
a
)

(m+n)\mathcal{G}(a^{2})=2m\mathcal{G}(a)a^{*}+2na\mathcal{F}(a)

for all

a
∈
𝒜

{a\in\mathcal{A}}

. Using the theory of functional identities and the structure of involutions on matrix algebras, we prove that if

ℱ

{\mathcal{F}}

and

𝒢

{\mathcal{G}}

are additive, then

𝒢
=
0

{\mathcal{G}=0}

. We also show that, in case ‘

*

*

’ is any nonidentity anti-automorphism, the same conclusion holds if either ‘

*

{*}

’ is not identity on

𝒵
⁢

(
𝒜
)

{\mathcal{Z}(\mathcal{A})}

or

𝒜

{\mathcal{A}}

is a PI-ring.
Exponential stability of the von Kármán system with internal damping
Authors: Raposo Carlos , Martins Roseane , Ribeiro Joilson , Vera Octavio 
Published: August 2023

Abstract
This work deals with a von Kármán system with internal damping. For the solution’s existence, we use nonlinear semigroup theory tools. We construct an evolution system by nonlinear Lipschitz perturbation of a semigroup of contractions. We apply the energy method for the asymptotic behavior, which uses suitable multipliers to construct a Lyapunov functional that leads to exponential decay.