bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of elimination diet on quality of life and eating behavior in children with severe atopic dermatitis and food allergies
Authors: Emeliashenkov E. E. , Makarova S. G. , Murashkin N. N. , Galimova A. A. , Pronina I. Y. , Yasakov D. S. 
Published: June 2023

Relevance of topic. The course of atopic dermatitis complicated by food allergies, as well as the use of an elimination diet, can significantly worsen patient’s quality of life and affect his eating behavior.Aim of the study was to assess indicators of the quality of life and eating behavior in children with severe atopic dermatitis and food allergies.Methods. This study included children of age 4–13 years 11 months, hospitalized in Dermatology with the Laser Surgery department in the National Medical Research Center of Children’s Health from September 2021 to May 2022. Anthropometric indices, the index of the influence of atopic dermatitis on the quality of life, eating behavior parameters, bioimpedance analysis of body composition and analysis of the chemical composition of the diet were assessed in all children.Results. A total of 92 children were included in the study. The course of atopic dermatitis had a very strong and strong impact on the quality of life – in 25.6 % and 39.0 % of children, respectively. Itching in 83.6 % of children and sleep disturbance in 86.6 % of children had the greatest impact on the quality of life. When assessing the eating behavior, there was an increase in the indicators of «emotional undereating», «slowness in eating» and «desire to drink» and a decrease in the «enjoyment of food». When analyzing anthropometric indicators, a correlation was established between BAZ, an indicator of quality of life (r= –0.44, p=0.01) and the indicator «enjoyment of food» (r=0.19, p=0.01). A positive correlation was also found between the quality of life index, disease duration (r=0.57, p=0.01) and the number of food groups excluded from the diet (r=0.51, p=0.03). A negative correlation was found between the indicators of quality of life, «food responsiveness» (r= –0.49, p=0.04) and «enjoyment of food» (r= –0.57, p=0.01).Conclusions. Elimination diet has a significant impact on the quality of life and eating behavior of children with severe atopic dermatitis and food allergies. This suggests that the diet must be strictly justified both in terms of the set of excluded foods and in terms of its duration.
Variability of the lower limb symmetry index associated with the gait parameters in the overweight adult population with flatfoot: a case-control study
Authors: Casado-Hernández Israel , Becerro-de-Bengoa-Vallejo Ricardo , Losa-Iglesias Marta , Gómez-Salgado Juan , López-López Daniel , Bayod Javier 
Published: June 2023

Background: Adult acquired flatfoot is characterized by a medial arch collapse during monopodal support in the stance phase, developing eversion of the calcaneus and abduction of the forefoot linked to the hindfoot. The purpose of our research was to analyze the dynamic symmetry index in the lower limbs comparing patients with flatfoot and normal foot.Methods: A case-control study was carried out with a sample of 62 participants divided into two groups consisting of 31 participants were overweight with bilateral flatfoot and 31 participants with healthy feet. A portable plantar pressure platform with piezoresistive sensors was used to measure the load symmetry index in the lower limbs in the foot areas and gait phases.Results: Gait pattern analysis showed statistically significant differences in the symmetry index for lateral load (p = 0.004), the initial contact phase (p = 0.025) and the forefoot phase (p &lt; 0.001).Conclusion: The adults were overweight with bilateral flatfoot evidenced alterations in the symmetry index in the lateral load and in the initial contact and flatfoot contact phases, showing greater instability in overweight adult flatfoot compared to the people with normal feet.
The prospect of digital human communication for organizational purposes
Authors: Newman Sean A. , Gopalkrishnan Shalini 
Published: June 2023

IntroductionThere has been a great deal of excitement and discussion about the potential for artificial intelligence (AI) to improve business processes by providing more effective delivery options in cost-effective ways. One such way for many companies is the use of chatbots (AI tools to talk to customers) as their first line of customer service communication. Using digital human technology (AI with a digital human) such as a chatbot to improve communication engagement is increasing in many companies. Digital human communication has advantages over other communication modes, such as being available at any time for employees to consume and always having correctly, vetted information to share. Even though digital human technology offers great promise for organizational communication, the potential utility will be impacted by how employees perceive communication. For example, in-person conversations with business leaders or human resources may not be readily available, creating a positive perception of the communication availability of digital humans. However, if employees have a negative bias toward digital human communication, they may not perceive it as an effective source of communication.MethodThis experimental exploratory study was conducted to better understand the satisfaction and perceived effectiveness of digital human communication. It was assessed by using mixed methods across three groups of respondents. One group heard a company announcement in person, the second group read the same announcement in the form of an email, and the last group heard the message from an AI-generated digital human. The digital human created was the same as the in person human and the words were exactly the same. After the communication, the respondents took a survey assessing their satisfaction and perception of the communication modality they received.ResultsIt was found that users were satisfied with all 3 modes of communication, but the email was the most effective tool for most aspects of communication, even surpassing the human one for most aspects of satisfaction and effectiveness. Additionally, there was no perceived difference in organizational support for the 3 groups.DiscussionWhen subjects are exposed to something new, they immediately make an appraisal based on their perception of the usability and gain of that interaction which impacts their willingness to accept new technologies. As per our study, firms can start using Digital humans for communication for corporate announcements and even better would be an interactive digital human.
A computational study of the effects of size, location, and number of tears on haemodynamics in surgically repaired type A aortic dissection
Authors: Motoki Kyosuke , Zhu Yu , Mirsadraee Saeed , Rosendahl Ulrich , Pepper John , Xu Xiao Yun 
Published: June 2023

ObjectiveThis study aimed to comprehensively examine the roles of size, location, and number of tears in the progression of surgically repaired type A aortic dissection (TAAD) by assessing haemodynamic changes through patient-specific computational fluid dynamic (CFD) simulations.MethodsTwo patient-specific TAAD geometries with replaced ascending aorta were reconstructed based upon computed 15 tomography (CT) scans, after which 10 hypothetical models (5 per patient) with different tear configurations were artificially created. CFD simulations were performed on all the models under physiologically realistic boundary conditions.ResultsOur simulation results showed that increasing either the size or number of the re-entry tears reduced the luminal pressure difference (LPD) and maximum time-averaged wall shear stress (TAWSS), as well as areas exposed to abnormally high or low TAWSS values. Models with a large re-entry tear outperformed the others by reducing the maximum LPD by 1.88 mmHg and 7.39 mmHg, for patients 1 and 2, respectively. Moreover, proximally located re-entry tears in the descending aorta were more effective at reducing LPD than distal re-entry tears.DiscussionThese computational results indicate that the presence of a relatively large re-entry tear in the proximal descending aorta might help stabilize post-surgery aortic growth. This finding has important implications for the management and risk stratification of surgically repaired TAAD patients. Nevertheless, further validation in a large patient cohort is needed.
Multilingual RECIST classification of radiology reports using supervised learning
Authors: Mottin Luc , Goldman Jean-Philippe , Jäggli Christoph , Achermann Rita , Gobeill Julien , Knafou Julien , Ehrsam Julien , Wicky Alexandre , Gérard Camille L. , Schwenk Tanja , Charrier Mélinda , Tsantoulis Petros , Lovis Christian , Leichtle Alexander , Kiessling Michael K. , Michielin Olivier , Pradervand Sylvain , Foufi Vasiliki , Ruch Patrick 
Published: June 2023

ObjectivesThe objective of this study is the exploration of Artificial Intelligence and Natural Language Processing techniques to support the automatic assignment of the four Response Evaluation Criteria in Solid Tumors (RECIST) scales based on radiology reports. We also aim at evaluating how languages and institutional specificities of Swiss teaching hospitals are likely to affect the quality of the classification in French and German languages.MethodsIn our approach, 7 machine learning methods were evaluated to establish a strong baseline. Then, robust models were built, fine-tuned according to the language (French and German), and compared with the expert annotation.ResultsThe best strategies yield average F1-scores of 90% and 86% respectively for the 2-classes (Progressive/Non-progressive) and the 4-classes (Progressive Disease, Stable Disease, Partial Response, Complete Response) RECIST classification tasks.ConclusionsThese results are competitive with the manual labeling as measured by Matthew's correlation coefficient and Cohen's Kappa (79% and 76%). On this basis, we confirm the capacity of specific models to generalize on new unseen data and we assess the impact of using Pre-trained Language Models (PLMs) on the accuracy of the classifiers.
Mapping the leap: differences in quality improvement in relation to assessment rating outcomes
Authors: Davis Belinda , Dunn Rosemary , Harrison Linda J. , Waniganayake Manjula , Hadley Fay , Andrews Rebecca , Li Hui , Irvine Susan , Barblett Lennie , Hatzigianni Maria 
Published: June 2023

IntroductionAustralia’s National Quality Standard (NQS) outlines the criteria to assess the quality of early childhood services. A four-point rating scale: (i) Exceeding NQS; (ii) Meeting NQS; (iii) Working Toward NQS; and (iv) Significant Improvement Required is applied to services following a regular assessment and rating process. Settings rated as Working Toward are reassessed within 12 months. Most settings achieved a one-step improvement in this Time 2 reassessment, moving to a Meeting rating but some settings made a two-step improvement, moving to an Exceeding rating. The QIP is a key document used by authorities to assess the quality of a service.MethodsA grounded theory, data driven approach was taken to deepen understanding of quality rating improvements in long day care services in Australia of quality rating improvements by early childhood education and care [ECEC] services in Australia. This study, part of the second phase of a three phase study involved a document analysis of the Time 2 Quality Improvement Plans (QIPs) of a representative sample of Long Day Care (LDC) services (n = 60) from all Australian states and territories to determine what factors may have contributed to these different levels of improvement, with a focus on Quality Area 1 (QA1) (Educational programs and practices) and Quality Area 7 (QA7) (Governance and leadership). The study utilized the semantic analysis tool Leximancer 4.5. Leximancer 4.5 statistically analyses the semantic relationships between concepts in documents by measuring word proximity and correlation. The software creates visual maps of concepts and their connections to each other in texts. Concepts located near one another on the map are more likely to be contextually related. This tool is particularly useful when there are multiple, complex documents to analyze, reducing the potential biases that can arise from documents that use language with which these researchers are very familiar with.ResultsThe analysis found clear differences between the Time 2 QIPs of services who had made a two-step rating improvement and those who made a one-step improvement. Two-step (Exceeding NQS) category improvers for QA1 placed attention in their QIPs on improvement to the program and overall practice, with an orientation to the role of the educational leader. Two-step (Exceeding NQS) category improvers for QA7 seemed to be more oriented to a systemic view of the processes encompassed by QA7; how the management of the service and information supports the work of educators, with stronger links made between leadership roles (the manager and nominated supervisor) and the work of educators.DiscussionThe QIPs demonstrated how the intentional and systemic processes in these quality areas related to practice, management, and leadership.
Therapeutic activity of lipoxin A4 in TiO2-induced arthritis in mice: NF-κB and Nrf2 in synovial fluid leukocytes and neuronal TRPV1 mechanisms
Authors: Saraiva-Santos Telma , Zaninelli Tiago H. , Manchope Marília F. , Andrade Ketlem C. , Ferraz Camila R. , Bertozzi Mariana M. , Artero Nayara A. , Franciosi Anelise , Badaro-Garcia Stephanie , Staurengo-Ferrari Larissa , Borghi Sergio M. , Ceravolo Graziela S. , Andrello Avacir Casanova , Zanoveli Janaína Menezes , Rogers Michael S. , Casagrande Rubia , Pinho-Ribeiro Felipe A. , Verri Waldiceu A. 
Published: June 2023

BackgroundLipoxin A4 (LXA4) has anti-inflammatory and pro-resolutive roles in inflammation. We evaluated the effects and mechanisms of action of LXA4 in titanium dioxide (TiO2) arthritis, a model of prosthesis-induced joint inflammation and pain.MethodsMice were stimulated with TiO2 (3mg) in the knee joint followed by LXA4 (0.1, 1, or 10ng/animal) or vehicle (ethanol 3.2% in saline) administration. Pain-like behavior, inflammation, and dosages were performed to assess the effects of LXA4in vivo.ResultsLXA4 reduced mechanical and thermal hyperalgesia, histopathological damage, edema, and recruitment of leukocytes without liver, kidney, or stomach toxicity. LXA4 reduced leukocyte migration and modulated cytokine production. These effects were explained by reduced nuclear factor kappa B (NFκB) activation in recruited macrophages. LXA4 improved antioxidant parameters [reduced glutathione (GSH) and 2,2-azino-bis 3-ethylbenzothiazoline-6-sulfonate (ABTS) levels, nuclear factor erythroid 2-related factor 2 (Nrf2) mRNA and Nrf2 protein expression], reducing reactive oxygen species (ROS) fluorescent detection induced by TiO2 in synovial fluid leukocytes. We observed an increase of lipoxin receptor (ALX/FPR2) in transient receptor potential cation channel subfamily V member 1 (TRPV1)+ DRG nociceptive neurons upon TiO2 inflammation. LXA4 reduced TiO2‐induced TRPV1 mRNA expression and protein detection, as well TRPV1 co-staining with p-NFκB, indicating reduction of neuronal activation. LXA4 down-modulated neuronal activation and response to capsaicin (a TRPV1 agonist) and AITC [a transient receptor potential ankyrin 1 (TRPA1) agonist] of DRG neurons.ConclusionLXA4 might target recruited leukocytes and primary afferent nociceptive neurons to exert analgesic and anti-inflammatory activities in a model resembling what is observed in patients with prosthesis inflammation.
The role of minimally invasive surgery in epithelial ovarian cancer treatment: a narrative review
Authors: Generali Matteo , Annunziata Gianluca , Pirillo Debora , D’Ippolito Giovanni , Ciarlini Gino , Aguzzoli Lorenzo , Mandato Vincenzo Dario 
Published: June 2023

ObjectivesThe aim of this narrative review is to summarize the available evidence on the use of minimal invasive surgery (MIS) in the management of epithelial ovarian cancer (EOC).BackgroundMIS is currently performed to stage and treat EOC at different stage of presentation. We will evaluate risks and benefits of minimally invasive surgery for early stage EOC treatment, then potential advantages provided by staging laparoscopy in identifying patients suitable for primary cytoreductive surgery (PDS) will be discussed. Finally we will investigate the growing role of MIS in the treatment of advanced EOC after neoadjuvant chemotherapy (NACT) and in the treatment of EOC recurrence.MethodsAn electronic database search was performed on PubMed, Medline, and Google Scholar for relevant studies up to December 2022.ConclusionLPS represents a feasible surgical procedure for the staging and treatment in early, advanced and EOC relapse in selected patients treated in high-volume oncological centers by surgeons with adequate experience in advanced surgical procedures. Despite the increasing use of MIS over the last few years, randomized clinical trials are still needed to prove its effectiveness.
Gut Streptococcus is a microbial marker for the occurrence and liver metastasis of pancreatic cancer
Authors: Yang Jinru , Ma Yuxi , Tan Qiaoyun , Zhou Bin , Yu Dandan , Jin Min , Zhang Tao , Liu Junli , Liu Hongli 
Published: June 2023

BackgroundGut microbiome plays an indispensable role in the occurrence and progression in various diseases. The incidence of pancreatic cancer (PC) and liver metastasis (PCLM) are high, most of them are found in advanced stage. Therefore, it is particularly necessary to search for predictive biomarkers, which are helpful for early detection and treatment, and thus improve the survival rate and quality of life of PC patients.MethodsWe retrospectively analyzed 44 pancreatic cancer patients (P group, n = 44) and 50 healthy people (N group, n = 50) from March 21, 2021 and August 2, 2022. Among all PC patients, we divided them into liver metastasis group (LM group, n = 27) and non-liver metastasis group (non-LM group, n = 17). DNA was extracted and 16S ribosomal RNA (16S rRNA) gene sequencing was performed. SPSS was used for statistical analyses and all bioinformatics analyses were based on QIIME2, p &lt; 0.05 were considered statistically significant.ResultsThe microbial richness and diversity of group P and LM were higher than that of group N and non-LM. LEfSe analysis found that Streptococcus was a significantly different microorganism, which was further identified by random forest (RF) model, and its ability to predict PC and PCLM was verified by ROC curve.ConclusionWe demonstrated significant differences in intestinal microbiome composition between PC patients and healthy people, and found that Streptococcus is a potential biomarker for early prediction of PC and PCLM, which is critical for early diagnosis of diseases.
Abnormal flow pattern of low wall shear stress and high oscillatory shear index in spontaneous vertebral artery dissection with vertebral artery hypoplasia
Authors: Bao Jiajia , Gan Xinling , Feng Wentao , Li Yanbo , Qiu Yue , Zhou Muke , Guo Jian , He Li 
Published: June 2023

IntroductionSpontaneous vertebral artery dissection (sVAD) might tend to develop in vertebral artery hypoplasia (VAH) with hemodynamic dysfunction and it is crucial to assess hemodynamics in sVAD with VAH to investigate this hypothesis. This retrospective study aimed to quantify hemodynamic parameters in patients with sVAD with VAH.MethodsPatients who had suffered ischemic stroke due to an sVAD of VAH were enrolled in this retrospective study. The geometries of 14 patients (28 vessels) were reconstructed using Mimics and Geomagic Studio software from CT angiography (CTA). ANSYS ICEM and ANSYS FLUENT were utilized for mesh generation, set boundary conditions, solve governing equations, and perform numerical simulations. Slices were obtained at the upstream area, dissection or midstream area and downstream area of each VA. The blood flow patterns were visualized through instantaneous streamline and pressure at peak systole and late diastole. The hemodynamic parameters included pressure, velocity, time-averaged blood flow, time-averaged wall shear stress (TAWSS), oscillatory shear index (OSI), endothelial cell action potential (ECAP), relative residence time (RRT) and time-averaged nitric oxide production rate (TARNO).ResultsSignificant focal increased velocity was present in the dissection area of steno-occlusive sVAD with VAH compared to other nondissected areas (0.910 m/s vs. 0.449 vs. 0.566, p &lt; 0.001), while focal slow flow velocity was observed in the dissection area of aneurysmal dilatative sVAD with VAH according to velocity streamlines. Steno-occlusive sVAD with VAH arteries had a lower time-averaged blood flow (0.499 cm3/s vs. 2.268, p &lt; 0.001), lower TAWSS (1.115 Pa vs. 2.437, p = 0.001), higher OSI (0.248 vs. 0.173, p = 0.006), higher ECAP (0.328 Pa−1 vs. 0.094, p = 0.002), higher RRT (3.519 Pa−1 vs. 1.044, p = 0.001) and deceased TARNO (104.014 nM/s vs. 158.195, p &lt; 0.001) than the contralateral VAs.ConclusionSteno-occlusive sVAD with VAH patients had abnormal blood flow patterns of focal increased velocity, low time-averaged blood flow, low TAWSS, high OSI, high ECAP, high RRT and decreased TARNO. These results provide a good basis for further investigation of sVAD hemodynamics and support the applicability of the CFD method in testing the hemodynamic hypothesis of sVAD. More detailed hemodynamic conditions with different stages of sVAD are warranted in the future.
Regional references vs. international standards for assessing weight and length by gestational age in Lithuanian neonates
Authors: Morkuniene Ruta , Cole Tim J. , Jakimaviciene Egle Marija , Bankauskiene Agne , Isakova Jelena , Drazdiene Nijole , Basys Vytautas , Tutkuviene Janina 
Published: June 2023

IntroductionThere is no global consensus as to which standards are the most appropriate for the assessment of birth weight and length. The study aimed to compare the applicability of regional and global standards to the Lithuanian newborn population by sex and gestational age, based on the prevalence of small or large for gestational age (SGA/LGA).Materials and MethodsAnalysis was performed on neonatal length and weight data obtained from the Lithuanian Medical Birth Register from 1995 to 2015 (618,235 newborns of 24–42 gestational weeks). Their distributions by gestation and sex were estimated using generalized additive models for location, scale, and shape (GAMLSS), and the results were compared with the INTERGROWTH-21st (IG-21) standard to evaluate the prevalence of SGA/LGA (10th/90th centile) at different gestational ages.ResultsThe difference in median length at term between the local reference and IG-21 was 3 cm–4 cm, while median weight at term differed by 200 g. The Lithuanian median weight at term was higher than in IG-21 by a full centile channel width, while the median length at term was higher by two channel widths. Based on the regional reference, the prevalence rates of SGA/LGA were 9.7%/10.1% for boys and 10.1%/9.9% for girls, close to the nominal 10%. Conversely, based on IG-21, the prevalence of SGA in boys/girls was less than half (4.1%/4.4%), while the prevalence of LGA was double (20.7%/19.1%).DiscussionRegional population-based neonatal references represent Lithuanian neonatal weight and length much more accurately than the global standard IG-21 which provides the prevalence rates for SGA/LGA that differ from the true values by a factor of two.