bluuebunny/crossref_metadata_2025_split huggingface dataset:
Performance amelioration of concerted voltage‐frequency regulation of multiarea hybrid power systems under restructured pattern using electric vehicles and interline power flow controller
Authors: Dekaraja Biswanath , Saikia Lalit C. , Ramoji Satish K. 
Published: February 2023

AbstractElectric power consumers need a stable and reliable electricity supply for their appliances. Voltage and frequency fluctuate owing to the gain in intermittent renewable energy sources in hybrid power systems (PSs). To mitigate these issues, this article proposed a new cascade controller named proportional‐derivative with filter and fractional‐order tilt‐integral‐derivative with filter (CPDN‐FOTIDN), controller for combined voltage and frequency control of three areas hybrid PS under deregulated environment. Hybrid PS comprises hydro, thermal, and geothermal power plant, modern electric vehicles (EVs), and interline power flow controller (IPFC). To make the analysis more realistic of the hybrid PS, more appropriate nonlinearities are considered. The artificial flora algorithm is employed for tuning controller parameters with several studies to obtain the desired response. Comparative analysis of dynamics responses reveals the superiority of the CPDN‐FOTIDN controller relative to PIDN and FOTIDN controllers under the three different power transactions. Investigations exhibited the performance enhancement of combined voltage and frequency control of hybrid PS after the integration of EVs into the considered system. Simulation results show that the EVs are a quick response in the presence of a CPDN‐FOTIDN controller compared to TID, and FOTID controllers during the system disturbance. Inter‐area oscillations improve after integration of IPFC into the system and the optimal location was found between area 1 and 2. Sensitivity studies demonstrated the sturdiness of the proposed controller against a wide variation of the system loading.
Opportunities and challenges of hole transport materials for high‐performance inverted hybrid‐perovskite solar cells
Authors: Li Ru , Liu Xue , Chen Jiangzhao 
Published: February 2023

AbstractInverted perovskite solar cells (inverted‐PSCs) have exhibited advantages of longer stability, less hysteresis, and lower fabrication temperature when compared to their regular counterparts, which are important for industry commercialization. Because of the great efforts that have been conducted in the past several years, the obtained efficiency of inverted‐PSCs has almost caught up with that of the regular ones, 25.0% versus 25.7%. In this perspective, the recent studies on the design of high‐performance inverted‐PSCs based on diverse hole transport materials, as well as device fabrication and characterization are first reviewed. After that, the authors moved on to the interface and additive engineering that were exploited to suppress the nonradiative recombination. Finally, the challenges and possible research pathways for facilitating the industrialization of inverted‐PSCs were envisaged.
Understanding governance barriers and enablers for municipal and regional transition towards sustainability—Presenting a comprehensive diagnostic tool based on six case studies in Sweden
Authors: Wälitalo Lisa , Callaghan Edith , Robèrt Karl‐Henrik , Broman Göran 
Published: February 2023

AbstractMunicipal and regional leaders' achievements for synchronised sustainability transitions are still not enough. Systemic, systematic and strategic cross‐sectoral collaboration and co‐creation are needed. However, sectors isolated in silos leads to suboptimal measures and strategies, and a reductionist view on what hinders and enables joint action towards full sustainability. Consequently, methodological support for addressing the coordinative challenge is often not asked for. This study investigates the observed reductionist perspective as foundation for developing enhanced methodological support for strategic sustainable development (SSD) and further aimed to gain insight into how leaders can be better supported to understand their current reality of barriers and enablers for cross‐sectoral SSD work and to prototype such support. Results from fieldwork with leaders in six municipalities and regions suggest that both frequency and depth of barriers and enablers in relation to elements for SSD are insufficient. Nine categories were identified and combined with SSD core elements into a diagnostic tool.
Pharmacist‐delivered comprehensive medication management in a substance use disorder clinic, an 18‐month descriptive study
Authors: Tran Loan , Hager Keri D. 
Published: February 2023

AbstractIntroductionPharmacists have expanded their roles within interprofessional teams in substance use disorder (SUD) care, but data characterizing pharmacist‐delivered comprehensive medication management (CMM) in outpatient SUD treatment are limited.ObjectivesThe purpose of this study was to characterize the patient population, and medication therapy problems (MTPs), and describe considerations for CMM development and implementation in an outpatient SUD treatment setting.MethodsAn observational, prospective, descriptive study was conducted in an outpatient SUD center. A clinical pharmacist provided CMM services to referred clients and documented data elements after each visit. The pharmacist comprehensively assessed clients' complete regimens to optimize medication use through collaboration with the clients and other healthcare providers. A post‐CMM electronic survey was sent to the clients' care teams to assess their attitudes and collect feedback regarding the collaboration process. Descriptive statistics were employed to describe the population, CMM services, MTPs, and survey responses.ResultsFrom April 1, 2021, to September 30, 2022, a total of 187 CMM encounters were delivered to a total of 112 clients with SUD. Nearly all patients (99%) had opioid use disorder as their primary diagnosis and the vast majority (95%) were receiving methadone treatment. Clients’ mean age was 39‐years‐old with an average of eight medications and six medical conditions. Of 201 MTPs identified, 54 MTPs (27%) were marked as “resolved” at follow‐up visits. The most commonly identified MTP category was the need for additional drug therapy (31%). The care team survey showed 100% agreed or strongly agreed that the CMM consult was helpful to the clients and the care team members.ConclusionPharmacist‐delivered CMM in a SUD treatment setting was feasible and well perceived by care team members as helpful to bridge existing gaps in access to biomedical care, medication optimization, and medication use care coordination.
Novel ferrocene‐containing triacyl derivative of resveratrol improves viability parameters in ovary cells
Authors: Kmetič Ivana , Murati Teuta , Kovač Veronika , Jurčević Irena Landeka , Šimić Branimir , Radošević Kristina , Miletić Marina 
Published: February 2023

AbstractBesides the use of resveratrol as a drug candidate, there are obstacles mainly due to its poor pharmacokinetic properties. Numerous studies are being conducted on the synthesis of resveratrol derivatives that exhibit enhanced biological activity. The aim of our research was to investigate activity of the newly synthesized ferrocene‐containing triacyl derivative of resveratrol to achieve cell protection from endo/exogenous ROS and reduction in cell death by assessing multiple endpoints. Our research showed that both resveratrol and the resveratrol derivatives (1–100 μM) lower the levels of ROS in CHO‐K1 cells. Resveratrol at doses <20 μM had little or no effect on cell proliferation, while at higher doses, a significant inhibitory effect on cell proliferation and viability has been noticed. The activity of the new derivative was significantly altered compared to resveratrol—cellular viability was not suppressed regardless of the concentration applied, and the extent of apoptosis was low. In summary, the new ferrocene‐resveratrol derivative has the potential to protect cells from oxidative stress due to its low cytotoxicity and retained antioxidant properties, whereas caution should be exercised with resveratrol at higher doses, as it significantly impairs cell viability and induces cell death. By linking ROS to specific diseases (relevance in neurodegenerative, cardiovascular, and neoplastic diseases), we can assume that the new resveratrol derivative can prevent or alleviate the mentioned disorders. Furthermore, recognition of the resveratrol derivative as an anti‐apoptotic chemical could be useful in the cultivation of various cell lines on a large scale in the industrial biotechnology.
3D‐Printed conductive polymeric scaffolds with direct current electrical stimulation for enhanced bone regeneration
Authors: Dixon Damion T. , Gomillion Cheryl T. 
Published: February 2023

AbstractVarious methods have been used to treat bone defects caused by genetic disorders, injury, or disease. Yet, there is still great need to develop alternative approaches to repair damaged bone tissue. Bones naturally exhibit piezoelectric potential, or the ability to convert mechanical stresses into electrical impulses. This phenomenon has been utilized clinically to enhance bone regeneration in conjunction with electrical stimulation (ES) therapies; however, oftentimes with critical‐sized bone defects, the bioelectric potential at the site of injury is compromised, resulting in less desirable outcomes. In the present study, the potential of a 3D‐printed conductive polymer blend to enhance bone formation through restoration of the bioelectrical microenvironment was evaluated. A commercially available 3D printer was used to create circular, thin‐film scaffolds consisting of either polylactide (PLA) or a conductive PLA (CPLA) composite. Preosteoblast cells were seeded onto the scaffolds and subjected to direct current ES via a purpose‐built cell culture chamber. It was found that CPLA scaffolds had no adverse effects on cell viability, proliferation or differentiation when compared with control scaffolds. The addition of ES, however, resulted in a significant increase in the expression of osteocalcin, a protein indicative of osteoblast maturation, after 14 days of culture. Furthermore, xylenol orange staining also showed the presence of increased mineralized calcium nodules in cultures undergoing stimulation. This study demonstrates the potential for low‐cost, conductive scaffolding materials to support cell viability and enhance in vitro mineralization in conjunction with ES.
Anatomical changes of the beetle digestive tract during metamorphosis correspond to dietary changes
Authors: Chiang Min‐Rou , Shelomi Matan 
Published: February 2023

AbstractDuring pupation, the tissues of holometabolous insects change in preparation for the adult lifestyles, although little literature exists examining this hidden process in detail. Using beetles as a model, we hypothesized that species where the adult and larva have the same diets will show less pronounced changes of the digestive tract during metamorphosis than species where the adults diets differ. We also wanted to observe these changes and document them at a level of detail missing from the current record. We compared the structure of the digestive tracts of scarab beetles Oryctes rhinoceros, Thaumastopeus shangaicus, and Protaetia spp. (Coleoptera: Scarabaeidae)—where the larvae eat wood, soil, or compost while the adults feed on soft plant matter, tree sap, and rotting fruits—with the tortoise beetle, Cassida circumdata (Coleoptera: Chrysomelidae), which feeds on leaves as both larva and adult. In the scarab beetles we observed considerable changes in the digestive tracts during the pupal stage, which we could divide into distinct stages, while in the leaf beetle pupae, the gut did not change. This information can provide new insight into metamorphosis, and the illustrations of what occurs during pupation are novel contributions to this field that will facilitate future work.
Deep‐Learning Models for Detection and Localization of Visible Clinically Significant Prostate Cancer on Multi‐Parametric MRI
Authors: Sun Zhaonan , Wu Pengsheng , Cui Yingpu , Liu Xiang , Wang Kexin , Gao Ge , Wang Huihui , Zhang Xiaodong , Wang Xiaoying 
Published: February 2023

BackgroundDeep learning for diagnosing clinically significant prostate cancer (csPCa) is feasible but needs further evaluation in patients with prostate‐specific antigen (PSA) levels of 4–10 ng/mL.PurposeTo explore diffusion‐weighted imaging (DWI), alone and in combination with T2‐weighted imaging (T2WI), for deep‐learning‐based models to detect and localize visible csPCa.Study TypeRetrospective.PopulationOne thousand six hundred twenty‐eight patients with systematic and cognitive‐targeted biopsy‐confirmation (1007 csPCa, 621 non‐csPCa) were divided into model development (N = 1428) and hold‐out test (N = 200) datasets.Field Strength/SequenceDWI with diffusion‐weighted single‐shot gradient echo planar imaging sequence and T2WI with T2‐weighted fast spin echo sequence at 3.0‐T and 1.5‐T.AssessmentThe ground truth of csPCa was annotated by two radiologists in consensus. A diffusion model, DWI and apparent diffusion coefficient (ADC) as input, and a biparametric model (DWI, ADC, and T2WI as input) were trained based on U‐Net. Three radiologists provided the PI‐RADS (version 2.1) assessment. The performances were determined at the lesion, location, and the patient level.Statistical TestsThe performance was evaluated using the areas under the ROC curves (AUCs), sensitivity, specificity, and accuracy. A P value <0.05 was considered statistically significant.ResultsThe lesion‐level sensitivities of the diffusion model, the biparametric model, and the PI‐RADS assessment were 89.0%, 85.3%, and 90.8% (P = 0.289–0.754). At the patient level, the diffusion model had significantly higher sensitivity than the biparametric model (96.0% vs. 90.0%), while there was no significant difference in specificity (77.0%. vs. 85.0%, P = 0.096). For location analysis, there were no significant differences in AUCs between the models (sextant‐level, 0.895 vs. 0.893, P = 0.777; zone‐level, 0.931 vs. 0.917, P = 0.282), and both models had significantly higher AUCs than the PI‐RADS assessment (sextant‐level, 0.734; zone‐level, 0.863).Data ConclusionThe diffusion model achieved the best performance in detecting and localizing csPCa in patients with PSA levels of 4–10 ng/mL.Evidence Level3Technical EfficacyStage 2
Ion‐selective electrodes for quick on‐farm determination of ammonium and potassium concentrations in pig slurry
Authors: Piepel Max‐Frederik , Dittert Klaus , Olfs Hans‐Werner 
Published: February 2023

AbstractBackgroundPig slurries account for a large proportion of the organic manure available worldwide. Because of the large range of slurry compositions, farmers need fast and accurate alternatives to laboratory methods to assess nutrient concentrations in these farm‐based fertilizers. In this way, nutrient emissions into the environment can be reduced and targeted nutrition of crops can be implemented, while mineral fertilizers can be saved.AimThe objective was to evaluate whether it is possible to rapidly determine ammonium and potassium concentrations in pig slurries on‐farm using ion‐selective electrodes (ISE) and to compare the measurement with established methods.MethodsA total of 391 pig slurry samples were collected from farms in north‐west Germany, and ammonium and potassium concentrations were analyzed in the laboratory. Then the composition of pig slurries was measured with ISE, the Quantofix‐N‐Volumeter (QV) and an electrical conductivity (EC) meter and regression models were used to evaluate the on‐farm quick tests.ResultsFor the 391 pig slurries studied, regressions with an R2 of 0.92 for ammonium and 0.91 for potassium were achieved for concentrations measured with the ISE in comparison with laboratory analyzes. The model fits for the electrodes were significantly higher than those based on the EC for ammonium and potassium, and it was equivalent to the QV method for the assessment of the ammonium concentration.ConclusionDue to the simple and rapid measurement, ISE offer high potential for on‐farm quantification of ammonium and potassium concentrations in pig slurries.
Land acquisition in rural tourism destinations: How social relations influence cooperative behaviours?
Authors: Wang Xinrui , Sun Jiuxia 
Published: February 2023

AbstractLand acquisition is becoming prevalent in most rural destinations. This study investigates the dynamic interaction process between rural residents regarding tourism‐led land acquisition and analyses how social relations influence cooperative behaviours by using social network analysis. The findings suggest that informal social relations between rural residents transmit influence and information, generating significantly positive impacts on individuals' land acquisition decisions. The multiple regression‐quadratic assignment procedure results further show that residential ties and political ties positively relate to the second land acquisition decision and that dynamic changes in formal political relations significantly facilitate the cooperative behaviour of rural residents. Our study suggests that building diverse social linkages between local governments and rural residents is conducive to promoting cooperation, shedding light on rural cooperative behaviours and sustainable tourism development.
Euchromatic histone lysine methyltransferase 2 facilitates radioresistance in prostate cancer by repressing endoplasmic reticulum protein 29 transcription
Authors: Huang Zhi‐Chao , Huang Jun , Huang Chang‐Kun , Hou Yi , Zhu Bin 
Published: February 2023

AbstractProstate cancer is one of the most common cancers in men. This study was conducted to investigate the role of euchromatic histone lysine methyltransferase 2 (EHMT2) and endoplasmic reticulum protein 29 (ERP29) in the progression of radioresistance in prostate cancer. The expression of EHMT2 and ERP29 in prostate cancer cells and during the progression of radioresistance was detected using quantitative reverse transcription‐polymerase chain reaction and western blotting, and the interaction between EHMT2 and ERP29 was investigated. The proliferation of transfected cells under x‐ray irradiation was determined using the methyl thiazolyl tetrazolium and colony formation assays. Flow cytometry was used to analyze the apoptosis of the transfected cells under x‐ray irradiation. Nude mice were subcutaneously injected with prostate cancer (DU145) cells stably transfected with sh‐ERP29 or sh‐NC. The effect of ERP29 expression on radioresistance in nude mice was assessed by x‐ray irradiation. The expression of EHMT2 was upregulated and that of ERP29 was downregulated in prostate cancer cells during radioresistance progression. EHMT2 downregulation suppressed radioresistance in DU145 and androgen‐sensitive prostate cancer (LNCaP) cells. In irradiated DU145 cells, EHMT2 inhibition decreased the number of colonies and accelerated apoptosis. The transcription of ERP29 was suppressed by EHMT2 by upregulating H3K9me2 and downregulating H3K4me3, thereby regulating radioresistance in prostate cancer cells. In addition, the downregulation of ERP29 promoted the progression of radioresistance in prostate cancer cells in nude mice. EHMT2 promotes radioresistance in prostate cancer cells by repressing ERP29 transcription.
Microplastic Detection and Analysis from Water and Sediment: A Review
Authors: Sajad Samreen , Allam Bharat Kumar , Mushtaq Zainab , Banerjee Sushmita 
Published: February 2023

AbstractThe presence and distribution of microplastics (MPs, <5 mm) has been reported worldwide in the aquatic ecosystem and is identified as emerging pollutant that can adversely affect the health of aquatic environment. The production and consumption of plastics has increased tremendously worldwide because of their properties including pliability, low cost, versatility, durability, and lightweight. Currently, the global production of plastics exceeds 320 million tonnes (Mt) per year, with single‐use plastic accounting for more than 40% of this total. Because plastic is non‐biodegradable, the majority of its annual production accumulates and finally enters the aquatic systems. Aquatic biota may suffer physical damages, fatigue, reduced appetite, blockage of metabolic channels, and altered feeding behavior due to consumption of MPs. Occurrence of MPs in air and food samples has been documented across the world. Thus, the MPs may also pose a great risk to the health of human beings, because of the human exposure to MPs and their concerned harmful contaminants through food chain or ingestion through the air. Due to the vast abundance and deleterious effects of MPs, more studies are focusing on MPs to estimate their dispersion, fate, quantity, and transport in the global aquatic systems. Through this work we have reviewed various analytical techniques of MPs including the collection of samples from surface water and sediments, identification, and quantification. One of the most prevalent techniques for recognizing MPs is visual categorization, which can be improved by combining it with other techniques viz. spectrometry and thermal methods. This review provides an insight about the following objectives: (1) the global occurrence and distribution of MPs, (2) the extensive analysis of effects of MPs on aquatic biota, and (3) the assessment of the current methods for MP sampling and analysis.
Tea Plant Leaves for Green Synthesis of Metallic Nanoparticles
Authors: Ismael Alaa Falih , Ahmed Naser M. , Ibrahim Khalid H. , AL‐Kubaisi Ahmed A. 
Published: February 2023

AbstractSynthesis of metallic nanoparticles using tea plant leaves is a well‐recognized and non‐toxic method. During the last few decades, synthesis of metal nanoparticles using plant extract is useful not only because of its reduced environmental but also because it can be used to produce large quantities of nanoparticles. Plant extracts may act both as reducing agents and stabilizing agents in the synthesis of nanoparticles, this has motivated the researchers to synthesis the nanoparticles using this route that allows better control of shape and size for various applications. This paper reviews the methods of synthesizing by using metals (e.g., gold [Au], silver [Ag], Iron [Fe], Cadmium [Cd], Palladium [Pd], copper [Cu]), nanoparticles from tea plant leaves extracts as well as their characteristics and some applications. The aim of this review is to report the effect of tea extraction for synthesis metallic nanoparticles (NPs) and compare the nanoscale properties and its applications.
Electro‐Optical Properties of MBBA Liquid Crystal Surrounded by Acetonitrile Medium Enhanced under the Presence of Electric Field: An Ab Initio Study
Authors: Sahu Teekendra Kumar , Chauhan Madan Singh , Sharma Dipendra , Tiwari Sugriva Nath 
Published: February 2023

AbstractThis study has used ab initio technique to investigate the electro‐optical and electronic properties of N‐(4‐methoxybenzylidene)‐4‐butylaniline (MBBA), a nematic liquid crystal between 21 and 48 °C, surrounded by gas and acetonitrile medium, in the presence and absence of electric field. The optimization and analysis of various electro‐optical and electronic parameters along with absorption spectrum have been performed using ωB97xD/6‐311+G(d,p) and M062X/6‐311+G(d,p) methods. Under the electric field, electro‐optical parameters of MBBA surrounded by acetonitrile are increased, indicating its suitability for display device development application. Global reactivity descriptors reveal that electronic properties of the MBBA LC also high in acetonitrile medium as compared to that of the gas. Furthermore, using second order perturbation theory and the multicentered‐multipole expansion technique, the mutual interactions between a pair of MBBA molecules are examined, revealing the nematic behavior of MBBA molecule.