bluuebunny/crossref_metadata_2025_split huggingface dataset:
DeepHAR: a deep feed-forward neural network algorithm for smart insole-based human activity recognition
Authors: D’Arco Luigi , Wang Haiying , Zheng Huiru 
Published: March 2023

AbstractHealth monitoring, rehabilitation, and fitness are just a few domains where human activity recognition can be applied. In this study, a deep learning approach has been proposed to recognise ambulation and fitness activities from data collected by five participants using smart insoles. Smart insoles, consisting of pressure and inertial sensors, allowed for seamless data collection while minimising user discomfort, laying the baseline for the development of a monitoring and/or rehabilitation system for everyday life. The key objective has been to enhance the deep learning model performance through several techniques, including data segmentation with overlapping technique (2 s with 50% overlap), signal down-sampling by averaging contiguous samples, and a cost-sensitive re-weighting strategy for the loss function for handling the imbalanced dataset. The proposed solution achieved an Accuracy and F1-Score of 98.56% and 98.57%, respectively. The Sitting activities obtained the highest degree of recognition, closely followed by the Spinning Bike class, but fitness activities were recognised at a higher rate than ambulation activities. A comparative analysis was carried out both to determine the impact that pre-processing had on the proposed core architecture and to compare the proposed solution with existing state-of-the-art solutions. The results, in addition to demonstrating how deep learning solutions outperformed those of shallow machine learning, showed that in our solution the use of data pre-processing increased performance by about 2%, optimising the handling of the imbalanced dataset and allowing a relatively simple network to outperform more complex networks, reducing the computational impact required for such applications.
Semi-Algebraic Functions with Non-Compact Critical Set
Authors: Dutertre Nicolas , Moya Pérez Juan Antonio 
Published: March 2023

AbstractLet $$X\subset {\mathbb {R}}^n$$

X
⊂

R

n

be a closed semi-algebraic set, $$F:{\mathbb {R}}^n\rightarrow {\mathbb {R}}$$

F
:

R

n

→
R

be a $${\mathcal {C}}^2$$

C

2

semi-algebraic function and $$f=F_{|X}:X\rightarrow {\mathbb {R}}^n$$

f
=

F

|
X

:
X
→

R

n

be the restriction of F to X. We define the global index of a critical value $$c_i$$

c
i

of f and prove an index formula for $$\chi (X)$$

χ
(
X
)

that generalizes a result previously proved by the authors for the case of isolated critical points. We define also new indices at infinity and prove an alternative index formula for $$\chi (X).$$

χ
(
X
)
.
lncRNA H-19 and miR-200a implication and frequency of lncRNA H-19 rs2170425 SNP in ulcerative colitis and Crohn’s disease
Authors: Khalil Ebtsam H. , Shaker Olfat G. , Hasona Nabil A. 
Published: March 2023

AbstractInflammation’s impact on inflammatory bowel diseases is mostly due to altered non-coding RNA expression. This study aimed to explore the rs2107425 polymorphism in the long non-coding RNA gene H19 (lncRNA H-19) and emphasize the involvement of miR-200a and lncRNA H-19 expression in ulcerative colitis (UC) and Crohn’s disease (CD). One hundred and ten participants, ranging in age from 22 to 58 years, participated in the current investigation study. Study participants were classified into forty healthy participants, thirty-four patients with UC, and thirty-six patients with CD. Participants with ulcerative colitis and Crohn’s disease experienced a considerable elevation in C-reactive protein, total leucocyte count (TLC), platelets, and erythrocyte sedimentation rate (ESR), whereas a noticeable decrease in hemoglobin. Additionally, ulcerative colitis and Crohn’s disease both have markedly increased expression of lncRNA H-19 and miR-200a. The frequency of the CT + TT genotype of the rs2170425 lncRNAH-19 SNP was linked to susceptibility to IBDs. lncRNA H-19 and miR-200a can be used as non-invasive diagnostic biomarkers for follow-up patients with ulcerative colitis and Crohn’s disease.
Adjacent segment mobility after ACDF considering fusion status at the implant insertion site
Authors: Godlewski Bartosz , Bebenek Adam , Dominiak Maciej , Bochniak Marcin , Cieslik Piotr , Pawelczyk Tomasz 
Published: March 2023

Abstract
Purpose
This paper sets out to analyse mobility changes in segments adjacent to the operated segment. Additionally, it investigates the relationship between the degree of fusion in the operated disc space and mobility changes in the adjacent segments.

Methods
In total, 170 disc spaces were operated on in 104 consecutive patients qualified for one- or two-level surgery. The degree of mobility of segments directly above and below the implant insertion site was calculated. Measurements were performed the day before the surgery and 12 months post-surgery. Functional (flexion and extension) radiographs of the cervical spine and CT scans obtained 12 months post-surgery were used to evaluate the fusion status. The results were subjected to statistical analysis.

Results
Statistically significant increase in mobility was recorded for the segments situated immediately below the operative site, with a mean change in mobility of 1.7 mm. Complete fusion was demonstrated in 101 cases (71.1%), and partial fusion in 43 cases (29.9%). In the complete fusion subgroup, the ranges of both flexion and extension in the segments directly below the operative site were significantly greater than those in the partial fusion (pseudoarthrosis) subgroup.

Conclusion
The mobility of the adjacent segment below the implant insertion site was significantly increased at 12 months post-ACDF surgery. The range of this compensatory hypermobility was significantly greater in patients with complete fusion at the ACDF site than in cases of pseudoarthrosis. Implant subsidence was not associated with mobility changes in the segments directly above or directly below the site of ACDF surgery.
Functional neurological outcome of spinal cavernous malformation surgery
Authors: Rauschenbach Laurèl , Santos Alejandro N. , Engel Adrian , Olbrich Angelina , Benet Arnau , Li Yen , Schmidt Börge , Gembruch Oliver , Özkan Neriman , Jabbarli Ramazan , Wrede Karsten H. , Siegel Adrian , Lawton Michael T. , Sure Ulrich , Dammann Philipp 
Published: March 2023

Abstract
Purpose
Spinal cavernous malformations (SCM) present a risk for intramedullary hemorrhage (IMH), which can cause severe neurologic deficits. Patient selection and time of surgery have not been clearly defined.

Methods
This observational study included SCM patients who underwent surgery in our department between 2003 and 2021. Inclusion required baseline clinical factors, magnetic resonance imaging studies, and follow-up examination. Functional outcome was assessed using the Modified McCormick scale score.

Results
Thirty-five patients met the inclusion criteria. The mean age was 44.7 ± 14.5 years, and 60% of the patients were male. In univariate analysis, the unfavorable outcome was significantly associated with multiple bleeding events (p = .031), ventral location of the SCM (p = .046), and incomplete resection (p = .028). The time between IMH and surgery correlated with postoperative outcomes (p = .004), and early surgery within 3 months from IMH was associated with favorable outcomes (p = .033). This association remained significant in multivariate logistic regression analysis (p = .041).

Conclusions
Removal of symptomatic SCM should be performed within 3 months after IMH when gross total resection is feasible. Patients with ventrally located lesions might be at increased risk for postoperative deficits.
Do associated proximal fibula fractures help predict the severity of tibial plateau fractures?
Authors: Mackie Duncan B. , Mitchell Brendon C. , Siow Matthew Y. , Onodera Keenan M. , Berger Garrett K. , Kent William T. 
Published: March 2023

Abstract
Purpose
Proximal fibula fractures are often associated with tibial plateau fractures, but their relationship is poorly characterized. The purpose of this study was to better define the relationship between tibial plateau injury severity and presence of associated soft tissue injuries.

Methods
A retrospective review was performed on all operatively treated tibial plateau fractures at a Level 1 trauma center over a 5-year period. Patient demographics, injury radiographs, CT scans, operative reports and follow-up were reviewed.

Results
Queried tibial plateau fractures from 2014 to 2019 totaled 217 fractures in 215 patients. Fifty-two percent were classified as AO/OTA 41B and 48% were AO/OTA 41C. Thirty-nine percent had an associated proximal fibula fracture. The presence of a proximal fibula fracture had significant correlation with AO/OTA 41C fractures, as compared with AO/OTA 41B fractures (chi-square, p < 0.001). Of the patients with a lateral split depression type tibial plateau fracture, the presence of a proximal fibula fracture was associated with more articular comminution, measured by number of articular fragments (mean = 4.0 vs. 2.9 articular fragments, p = 0.004). There was also a higher rate of meniscal injury in patients with proximal fibula fractures (37% vs. 20%, p = 0.003).

Conclusions
There was a significant relationship between the higher energy tibial plateau fracture type (AO/OTA 41C) and the presence of an associated proximal fibula fracture. The presence of a proximal fibula fracture with a tibial plateau fracture is an indicator of a higher energy injury and a higher likelihood of meniscal injury.
Coping strategies in patients with good outcome but chronic fatigue after aneurysmal subarachnoid hemorrhage
Authors: Ghafaji Hajar , Nordenmark Tonje Haug , Western Elin , Sorteberg Wilhelm , Karic Tanja , Sorteberg Angelika 
Published: March 2023

Abstract
Background
Fatigue is a highly prevalent and debilitating symptom among patients in the chronic phase of aneurysmal subarachnoid haemorrhage (aSAH) with no identified effective treatment. Cognitive therapy has been shown to have moderate effects on fatigue. Delineating the coping strategies used by patients with post-aSAH fatigue and relating them to fatigue severity and emotional symptoms could be a step towards developing a behavioural therapy for post-aSAH fatigue.

Methods
Ninety-six good outcome patients with chronic post-aSAH fatigue answered the questionnaires Brief COPE, (a questionnaire defining 14 coping strategies and three Coping Styles), the Fatigue Severity Scale (FSS), Mental Fatigue Scale (MFS), Beck Depression Inventory (BDI-II) and Beck Anxiety Inventory (BAI). The Brief COPE scores were compared with fatigue severity and emotional symptoms of the patients.

Results
The prevailing coping strategies were “Acceptance”, “Emotional Support”, “Active Coping” and “Planning”. “Acceptance” was the sole coping strategy that was significantly inversely related to levels of fatigue. Patients with the highest scores for mental fatigue and those with clinically significant emotional symptoms applied significantly more maladaptive avoidant strategies. Females and the youngest patients applied more “Problem-Focused” strategies.

Conclusion
A therapeutic behavioural model aiming at furthering “Acceptance” and reducing passivity and “Avoidant” strategies may contribute to alleviate post-aSAH fatigue in good outcome patients. Given the chronic nature of post-aSAH fatigue, neurosurgeons may encourage patients to accept their new situation so that they can start a process of positive reframing instead of being trapped in a spiral of futile loss of energy and secondary increased emotional burden and frustration.
The microbiota-gut-brain axis and perceived stress in the perinatal period
Authors: Long Emily S. , Penalver Bernabe Beatriz , Xia Kai , Azcarate-Peril M. Andrea , Carroll Ian M. , Rackers Hannah S. , Grewen Karen M. , Meltzer-Brody Samantha , Kimmel Mary C. 
Published: March 2023

Abstract
Perinatal perceived stress can contribute to worse health outcomes for the parent–child dyad. Given the emerging relationship between the microbiota-gut-brain axis and stress, this study sought to elucidate connections between bowel symptoms and the gut microbiome in relation to perceived stress at three time points in the perinatal period: two during pregnancy and one postpartum. Ninety-five pregnant individuals participated in a prospective cohort study from April 2017 to November 2019. Researchers assessed Perceived Stress Scale-10 (PSS); bowel symptoms (according to the IBS Questionnaire); psychiatrist assessment of new onset or exacerbated depression and anxiety; and fecal samples analyzed for alpha diversity (measures of gut microbiome diversity utilizing Shannon, Observed OTUs, and Faith’s PD) at each timepoint. Covariates included weeks of gestation and weeks postpartum. PSS scores were divided into “Perceived Self-Efficacy” and “Perceived Helplessness.” Increased gut microbial diversity was associated with decreased bowel symptoms, decreased overall perceived stress, increased ability to cope with adversity, and decreased distress in the postpartum period. This study found a significant association between a less diverse microbial community, lower self-efficacy early in pregnancy, and greater bowel symptoms and perceived helplessness later in the perinatal period, relationships that may ultimately point to novel diagnostic methods and interventions for perceived stress based on the microbiota-gut-brain axis.
Graphical Abstract
Including business strategy in model-driven methods: an experiment
Authors: Noel Rene , Panach Jose Ignacio , Pastor Oscar 
Published: March 2023

AbstractSoftware-centric organisations design a loosely coupled organisation structure around strategic objectives, replicating this design to their business processes and information systems. Nowadays, dealing with business strategy in a model-driven development context is a challenge since key concepts such as the organisation’s structure and strategic ends and means have been mostly addressed at the enterprise architecture level for the strategic alignment of the whole organisation, and have not been included into MDD methods as a requirements source. To overcome this issue, researchers have designed the LiteStrat, a business strategy modelling method compliant with MDD for developing information systems. This article presents an empirical comparison of LiteStrat and with i*, one of the most used models for strategic alignment in an MDD context. The article contributes with a literature review on the experimental comparison of modelling languages, the design of a study for measuring and comparing the semantic quality of modelling languages, and empirical evidence of the LiteStrat and i* differences. The evaluation consists of a 2 × 2 factorial experiment recruiting 28 undergraduate subjects. Significant differences favouring LiteStrat were found for models’ accuracy and completeness, while no differences in modeller’s efficiency and satisfaction were detected. These results yield evidence of the suitability of LiteStrat for business strategy modelling in a model-driven context.
Correlation of immune makers with HPV 16 infections and the prognosis in oropharyngeal squamous cell carcinoma
Authors: Zhu Yingying , Zhu Xiaoli , Diao Wenwen , Liang Zhiyong , Gao Zhiqiang , Chen Xingming 
Published: March 2023

Abstract
Objectives
This study aims to investigate the association of immune markers with high risk human papillomavirus 16 (HPV 16) infection status and to evaluate the prognostic value of programmed death ligand-1 (PD-L1) in patients with oropharyngeal squamous cell carcinoma (OPSCC).

Materials and methods
This retrospective study collected 50 cases of HPV positive and HPV negative OPSCC from January 2011 to December 2015. The correlation of CD8 + tumor infiltrating lymphocytes (TILs), programmed death-1 (PD-1), and PD-L1 expression with HPV 16 infection status was analyzed via immunofluorescent staining and quantitative real-time PCR.

Results
There was no significant difference in the baseline data between the two groups. Patients with HPV + OPSCC had better prognosis compared to HPV − patients (5-year overall survival [OS], 66% vs. 40%, P = 0.003; 5-year disease specific survival [DSS], 73% vs. 44%, P = 0.001). The expressions of immunity related makers were significantly higher in the HPV + group than the HPV − group (CD8 + TIL: P = 0.039; PD-L1: P = 0.005; PD-1: P = 0.044). Positive CD8 + TIL and PD-L1 were independent factors for better prognosis of OPSCC (DSS, P < 0.001; OS, P < 0.001, respectively). Kaplan–Meier survival analysis indicated that patients with TILs of high HPV + /CD8 + expression were more likely to have better prognosis than those with TILs of low HPV + /CD8 + expression (DSS, P < 0.001; OS, P < 0.001), TILs of high expression of HPV − /CD8 + (DSS, P = 0.010; OS, P = 0.032), and TILs of low expression of HPV − /CD8 + (DSS, P < 0.001; OS, P < 0.001). Furthermore, HPV + /PD-L1 + OPSCC patients had significant better prognosis compared to patients with HPV + /PD-L1 − (DSS, P < 0.001; OS, P = 0.004), HPV − /PD-L1 + (DSS, P = 0.010; OS, P = 0.048) and HPV − /PD-L1 − (DSS, P < 0.001; OS, P < 0.001).

Conclusions
HPV + OPSCC had a significantly better prognosis, and PD-L1 expression was elevated in HPV + OPSCC. PD-L1 positivity might be related to the better prognosis of HPV + OPSCC.

Clinical relevance
This study provides a theoretical basis and baseline data for the application of immune checkpoint inhibitors in head and neck tumors.
Electrochemistry needs electrochemists: “goodbye to rotating discs”
Authors: Compton Richard G. , Sokolov Stanislav V. 
Published: March 2023

AbstractThe essential need for expert, fully trained electrochemists in the successful application of the subject is illustrated with several examples including the use of rotating electrodes and impedance spectroscopy where the use of the techniques in “black box” mode non-experts is likely to lead to disappointment or embarrassment.
The effects of estradiol levels on crossmodal perception: a study on the sound induced flash illusion in healthy and menstrually related migraine individuals
Authors: Maccora Simona , Bolognini Nadia , Mannina Carlo , Torrente Angelo , Agnello Luisa , Lo Sasso Bruna , Ciaccio Marcello , Sireci Guido , Brighina Filippo 
Published: March 2023

Abstract
Objective
The sound-induced flash illusion (SIFI) is a valid paradigm to study multisensorial perception. In the “fission” SIFI, multiple flashes are perceived when observing a single flash paired with two or more beeps. SIFI is largely dependent on visual and acoustic cortex excitability; in migraine, dysfunctional cortical excitability affects SIFI perception. Since estrogen peak occurring during ovulation can increase neuronal excitability, the present study aims to verify whether cortical excitability shifts linked to the menstrual cycle could influence SIFI.

Methods
In a comparative prospective study, we tested the effect of estrogens on crossmodal perception using the SIFI. We recruited 27 females in reproductive age, including 16 healthy and 11 menstrually related migraine females, testing their proneness to SIFI on day 14 (high estradiol) and day 27 (low estradiol) of menstrual cycle.

Results
Women on day 14 reported less flashes than on day 27 (p = 0.02) in the fission illusion, suggesting a pro-excitatory effect of estradiol on visual cortex excitability during ovulation. Moreover, we confirmed that migraine women perceived less flashes (p = 0.001) than controls, independently from cycle phase. Non-migraineurs women significantly reported more flashes on day 27 than on day 14 (p = 0.04).

Conclusions
This study suggests that estradiol may influence the multisensory perception due to changes of visual cortex excitability, with high estradiol peak leading to increased visual cortical sensitivity during ovulation in non-migraineurs. Visual cortex hyperresponsiveness, here reflected by reduced SIFI, is not influenced by estradiol fluctuations in migraine women, as shown by reduced fission effects on day 14 and 27.
RIDA®GENE Helicobacter pylori PCR on the ELITe InGenius System
Authors: Bénéjat Lucie , Ducournau Astrid , Martins Chloé Domingues , Bessède Emilie , Lehours Philippe 
Published: March 2023

AbstractPCR detection of Helicobacter pylori infection in gastric biopsies allows the detection of this bacterium and the mutations associated with macrolide resistance. The aim of this study was to evaluate the performance of RIDA®GENE H. pylori PCR (r-Biopharm) on the ELITe InGenius System (Elitech). Two hundred gastric biopsies were obtained. These biopsies were ground in nutrient broth. Two hundred microliters of this suspension was treated with proteinase K, and then, 200 µL was transferred to an ELITe InGenius sample tube and tested using RIDA®GENE H. pylori PCR reagents. In-house H. pylori PCR was used as a reference. The sensitivity of RIDA®GENE H. pylori PCR with ELITe InGenius was 100%, the specificity was 98% (95% confidence interval (CI), 95.3–100%), the PPV was 98% (95% CI, 95.3–100%), and the NPV was 100% for the detection of H. pylori. All of these parameters were 100% for the categorization of macrolide resistance. The adaptation of RIDA®GENE H. pylori PCR reagents on the ELITe InGenius System was successful. This PCR is easy to use on this system.
Property rights, transaction costs, and the limits of the market
Authors: Guerriero Carmine 
Published: March 2023

AbstractTo clarify the determinants and interaction of property rights and transaction costs, I study the design of the property rights on either a good whose consensual transfer entails a transaction inefficiency or an upstream firm’s input whose random cost is nonverifiable and ex ante non-contractible. More disperse traders’ valuations and larger odds that the upstream party can appropriate the quasi-rent induced by contract incompleteness produce more severe transaction inefficiencies and larger incomplete contracting costs, respectively. Larger transaction costs, in turn, induce weaker property rights because of the trade-off between inefficient exclusion from trade/innovation and expropriation. These implications survive when some transactors have more political influence on institutional design, or I consider the disincentive effect of weak property rights. Furthermore, they are consistent with the interplay among proxies for the availability of technological progress, severity of transaction costs and strength of property rights for 139 countries observed between 2006 and 2018.