bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identifying outcome domains to establish a core outcome set for progressive pulmonary fibrosis: a scoping review
Authors: Delameillieure Anouk , Somogyi Vivien , Schenk Silja , Toreyin Nur , Stenzel Nikola , Van Bulck Liesbet , Breuls Sofie , Kreuter Michael , Wuyts Wim A. , Mogulkoc Nesrin , Boyd Jeanette , Jones Steve , Galvin Liam , Dobbels Fabienne 
Published: January 2025

IntroductionPeople with idiopathic pulmonary fibrosis (IPF) and other forms of progressive pulmonary fibrosis (PPF) have a high symptom burden and a poor health-related quality of life (HRQoL). Despite efforts to offer specialised treatment, clinical care for these patients remains suboptimal and several nonmedical needs remain unaddressed. Developing a core outcome set (COS) can help to identify a minimum set of agreed-upon outcomes that should be measured and acted-upon in clinical care.AimAs a first step towards developing a COS for IPF/PPF, we aimed to identify outcome domains investigated in IPF/PPF research.MethodsConducted within the COCOS-IPF (Co-designing a Core Outcome Set for and with patients with IPF) project, this scoping review follows Joanna Briggs Institute methodology and PRISMA (Preferred Reporting Items for Systematic reviews and Meta-Analyses) guidelines to search PubMed, Embase and Web of Science for quantitative, qualitative and mixed-methods papers. We extracted each paper's outcomes verbatim and classified them using the COMET (Core Outcome Measures in Effectiveness Trials) taxonomy. Then, the research team structured outcomes or concepts with similar meanings inductively into outcome domains.ResultsWe included 428 papers, extracting 1685 outcomes. Most outcomes (n=1340) were identified in quantitative sources, which we could classify in 64 outcome domains, with the main domains being “all-cause survival” (n=237), “lung function” (n=164) and “exercise capacity” (n=99). Qualitative sources identified 51 outcome domains, with the most frequent being “capability to do activities you enjoy” (n=31), “anxiety, worry and fear” (n=26) and “dealing with disease progression” (n=25).ConclusionsThe identified outcomes, spanning diverse domains, highlight the complexity of patient experiences and can form the basis to develop a COS for IPF/PPF clinical care, as well as future research.
Patient satisfaction with radio-frequency identification (RFID) tag localization compared with wire localization for nonpalpable breast lesions: the RFID trial
Authors: Pete Raphaël , Pinard Céleste , Sirodot Fanny , Molnar Ioana , Dressaire Margot , Ginzac Angeline , Abrial Catherine , Durando Xavier , Tekath Marielle 
Published: January 2025

Abstract

Background
Most breast cancers are detected at an early stage in which case conservative surgery is indicated. An accurate preoperative localization technique is essential for conservative surgery of non-palpable breast lesions. Currently, the gold standard technique is wire localization (WL). However, this technique has well-known drawbacks. Several wire-free techniques have been developed to overcome these drawbacks; one technique is localisation by Radiofrequency Identification (RFID). The purpose of this clinical trial was to assess the superiority of RFID tags (HOLOGIC) in terms of patient satisfaction, over wire localization of non-palpable breast lesions.

Methods
This was a single-centre, prospective, controlled and non-interventional trial. Patients were followed from their inclusion at the time of the preoperative consultation to the postoperative consultation, one month after surgery. Data on anxiety and satisfaction was collected from patients and clinicians using questionnaires, and clinical data was collected from the medical files. The primary outcome was the patients’ satisfaction scores, assessed using a visual analogue scale.

Results
Eighty patients were sequentially enrolled in two groups: the wire group (n = 40) and the RFID group (n = 40). One patient from the RFID group was excluded from the analysis because of a substantial migration during deployment. On a 10-point Visual Analogue Scale, the patients’ median satisfaction score was 9.8 (IQR = 1.32) for the wire group and 10 (IQR = 0.07) for the RFID group (p < 0.001). A reduction in pain between device insertion and surgery was observed in the RFID group (p = 0.009). The median placement time was shorter in the RFID group (15 min, IQR = 6) than in the wire group (20 min, IQR = 30) (p = 0.01).

Conclusion
Our results show a statistically significant difference in median patient satisfaction score with the localization of non-palpable breast cancer lesions using RFID tags compared to the use of the WL. Although our results did not show clinically significant outcomes in terms of satisfaction, RFID tags are a reliable alternative to WL and simplify the organization of patients’ healthcare trajectories.

Trial registration
ClinicalTrials.gov ID; NCT04750889 registered on February 11, 2021. https://clinicaltrials.gov/ct2/show/NCT04750889?term=rfid&draw=2&rank=1
Perceptions of cervical screening uptake amongst South Asian women in Ontario, Canada: a concept mapping study
Authors: Devotta Kimberly , Lofters Aisha , Bender Jacqueline , O’Campo Patricia 
Published: January 2025

Abstract

Background
Regular cervical screening can significantly reduce the onset and prevalence of cervical cancer. In Ontario, Canada, South Asian women have the lowest rates of cervical cancer screening among major ethnic groups in the province.

Methods
Using an innovative and participant-driven method called Concept Mapping (CM), we set out to understand how the lives and experiences of South Asian women living in Ontario shape their decisions around getting screened for cervical cancer. We engaged over 70 South Asian women and people who serve them in healthcare and community, to drive the CM process.

Results
Participants brainstormed 45 unique and distinct statements. Through sorting and map interpretation, participants identified and interpreted 6 clusters amongst the statements: (1) Personal beliefs and misconceptions around cervical cancer; (2) Education and knowledge issues around cervical cancer; (3) Cultural beliefs and influences specific to sexual health; (4) Barriers to prioritizing uptake of cervical screening; (5) System/ infrastructure gaps or inadequacies; and (6) Lack of comfort and supportive relationships in healthcare. Additional analysis shows us the interrelationships between the ideas. Statements within the clusters about education and knowledge issues around cervical cancer, personal beliefs and misconceptions, as well as cultural beliefs and influences specific to sexual health are viewed as distinct beliefs with clear effects on the uptake of cervical screening. More complex interrelationships are seen with the cluster of statements about barriers to prioritizing uptake of cervical screening.

Conclusions
As Ontario and many other jurisdictions around the world seek to strengthen cervical screening efforts in line with national and international goals to eliminate cervical cancer by 2040, it is critical to address underscreening. This CM study recognizes the value of engaging those most impacted by an issue, to identify and prioritize how and where to intervene to address low rates of cervical screening. To address underscreening we need to design multi-level interventions that address the identified ideas and the interrelationships among them.
Radiography may not be accurate in assessing acute ankle sprains in children
Authors: Li Xiongtao , Shen Xiantao , Wang Si , Sun Jie , Liu Zhaoting 
Published: January 2025

Abstract

Background
Acute ankle sprains are among the most common injuries in children and are often associated with chondral avulsion fractures and ligament injuries. However, radiography may not be sufficiently accurate for assessing cartilage and ligament injuries in children. The primary purpose of this study was to evaluate the necessity of radiography in the diagnosis of acute ankle sprains in children. The secondary purpose was to assess whether ultrasonography can effectively improve the diagnostic accuracy of acute ankle sprains in children.

Methods
We collected medical data from 78 children with acute ankle sprains who underwent both radiological and ultrasound examinations, 59 of whom also had ankle MRI results. The agreement between the radiographic and ultrasonographic findings in these 78 patients was assessed via Cohen’s kappa and McNemar tests. Using MRI results as the gold standard, the sensitivity, specificity, positive predictive value, and negative predictive value of radiography and ultrasonography were evaluated for the 59 patients who had MRI results. Cohen’s kappa and McNemar’s tests were also utilized to assess the reliability of radiography and ultrasonography in comparison to MRI.

Results
Among the 78 children with acute ankle sprains, 29 did not show fractures on radiological examination, but fractures were detected via ultrasound examination. Among these 29 fractures, 20 were chondral avulsion fractures of the distal fibula, and 9 were avulsion fractures of the lateral talus process. The agreement between radiography and ultrasonography was fair (Kappa = 0.250), and the difference was statistically significant (P < 0.001). Using MRI as the gold standard, radiography resulted in 17 false-negative cases for lateral ankle fractures, with a sensitivity of only 47%. Ultrasonography produced only one false-negative case, achieving a sensitivity of 97%. Ultrasonography showed substantial agreement with MRI (Kappa = 0.797), whereas radiography showed fair agreement with MRI (Kappa = 0.384).

Conclusions
Acute ankle sprains in children frequently result in a high incidence of chondral avulsion fractures. However, radiography may be inadequate for accurately diagnosing these fractures. Reliance on radiography alone may lead to a substantial number of false-negative cases. Compared with radiography, ultrasonography is highly accurate in the diagnosis of chondral avulsion fractures and ligament injuries in children. We believe that ultrasonography, as a noninvasive, radiation-free, and cost-effective dynamic diagnostic method, is particularly suitable for the early diagnosis of acute ankle sprains in children.

Level of evidence
Level III; Diagnostic Study.
Cost-effectiveness of watchful waiting versus immediate emergency department transfer after epinephrine autoinjector use in Canada
Authors: Yin Yiwei , Shoshan Moshe Ben , Shaker Marcus , Greenhawt Matthew , Johnson Kate M. 
Published: January 2025

Abstract

Background
Until recently, immediate emergency department (ED) transfer after food-related anaphylactic reactions was recommended regardless of symptom resolution following use of an epinephrine autoinjector (EAI). We evaluated the cost-effectiveness of delayed ED transfer after EAI use in non-medical settings (watchful waiting) compared to immediate ED transfer among pediatric patients with food allergies in Canada.

Methods
We developed a probabilistic Markov model of individuals starting at age of one year who are at risk of severe food-related allergic reactions requiring epinephrine. We evaluated medical costs (in 2022 Canadian dollars) and quality-adjusted life years (QALY) of each strategy over a 20-year horizon. In the base case, we assumed a tenfold increase in food allergy fatality for patients under watchful waiting, which we increased to 100- to 1,000-fold in sensitivity analysis. The analysis was conducted from the Canadian healthcare system perspective with a 1.5% annual discount rate and a willingness-to-pay (WTP) threshold of $50,000 per QALY.

Results
Immediate ED transfer following EAI use resulted in a decreased risk of food allergy fatality of 9.2 × 10− 5 over 20 years, which is equivalent to < 1 fatality per 200,000 patient-years. Watchful waiting resulted in cost savings of $1,157 per patient and a QALY loss of 7.28 × 10− 4; an incremental cost per QALY saved of $1,589,854. The incremental cost per death prevented with immediate ED transfer was $12,586,613. Watchful waiting remained cost-effective in all sensitivity and scenario analyses, except under extreme increases in fatality risk of 500-fold and 1,000-fold.

Conclusions
Watchful waiting for symptom re-occurrence following EAI administration in non-medical settings is cost-effective.
Construction and validation of an overconfidence scale in investment decisions
Authors: Costa Daniel Fonseca , Soares Cláudia Cardoso , de Melo Moreira Bruno César , Tonelli Adriano Olímpio 
Published: January 2025

Abstract
Existing studies that directly measure the three types of overconfidence—overprecision, overplacement, and overestimation—are largely exploratory, highlighting the need for further confirmatory research to establish robust overconfidence measures. Moreover, there is no comprehensive instrument for analyzing these types of overconfidence in the context of investment decisions. To address these gaps, the present study aims to develop and validate a scale for assessing overconfidence in investment decisions, considering its three forms. The research involved 380 Brazilian participants and employed confirmatory factor analysis and standard multivariate validation methods. The scale, based on a theoretical framework of the three types of overconfidence, consisted of 30 questions (10 for each type) designed to measure the degree of overconfidence in investment decision-making. The scale demonstrated acceptable factor loadings and internal and external validity, indicating its suitability for evaluating overconfidence in investment decisions. The standardized factor loadings showed p values < 0.01 for all factors. The average variance extracted was above 0.5, and the composite reliability exceeded 0.7 for all three constructs analyzed. These results support the convergent validity of the proposed measurement model. In this way, the developed scale fills a gap in the literature by providing a valid tool to assess overconfidence in investment decision-making, which can be practically applied by financial market participants, such as investors, fund managers, and financial professionals. This instrument enables more informed and personalized investment decisions, mitigates the risks of bias in decision-making, and contributes to a more efficient and resilient financial market.
Gastrointestinal Bile Salt Concentrations in Healthy Adults Under Fasted and Fed Conditions: A Systematic Review and Meta-Analysis for Mechanistic Physiologically-Based Pharmacokinetic (PBPK) Modelling
Authors: Santos Laura G. Al-Amiry , Musther Helen , Bala Neeru , Deferm Neel , Patel Gaurangkumar , Brouwers Joachim , Turner David B. 
Published: January 2025

Abstract
Bile salts are biosurfactants released into the intestinal lumen which play an important role in the solubilisation of fats and certain drugs. Their concentrations vary along the gastrointestinal tract (GIT). This is significant for implementation in physiologically based pharmacokinetic (PBPK) modelling to mechanistically capture drug absorption. The aims of this meta-analysis were to collate all appropriate data on intestinal bile salt concentrations in healthy adults across all GIT segments in fasted and fed states for the purpose of PBPK modelling. Terms relating to bile composition were searched in PubMed and Google Scholar from inception to May 2024. Selected studies included aspirated intestinal fluid collected via gastric tubes or colonoscopy. Results showed high variability across studies and a time-dependency for the fed state. Data were rich for the duodenum, which showed a two-fold increase for the fed state versus the fasted state within multiple studies. Peaks and troughs in bile salt concentrations along the GIT were observed for both fasted and fed states, likely due to segmental water absorption differences. The highest between subject variability was observed for the duodenum in the fasted and fed state and the fed proximal jejunum, distal ileum, and colon. The findings from this meta-analysis can be used for the purpose of PBPK modelling to capture segmental drug solubilisation and absorption in fasted and fed states. However, data are lacking under different fed conditions, especially following low-fat meals, so the impact of different fat content associated with different meals on bile salt concentrations cannot be discerned.

Graphical Abstract

Gastrointestinal bile salt concentrations in healthy subjects
A meta-analysis has been conducted to collate fasted and fed gastrointestinal bile salt concentrations in healthy subjects for the purpose of physiologically-based pharmacokinetic (PBPK) modelling within the Simcyp and other PBPK simulators. Values are presented as weighted means with coefficient of variability for each segment. These data will help improve mechanistic models of oral drug absorption.
The Association of the Coronavirus Disease-2019 Pandemic With Disparities in Maternal Outcomes
Authors: Glance Laurent G. , Joynt Maddox Karen E. , Christopher Glantz J. , Chandrasekar Eeshwar K. , Shippey Ernie , Wissler Richard N. , Stone Patricia W. , Shang Jingjing , Kundu Anjana , Dick Andrew W. 
Published: January 2025

BACKGROUND:
In the United States, Black and Hispanic patients have substantially worse maternal outcomes than non-Hispanic White patients. The goals of this study were to evaluate the association between the coronavirus disease-2019 (COVID-19) pandemic and maternal outcomes, and whether Black and Hispanic patients were disproportionately affected by the pandemic compared to White patients.

METHODS:
Multivariable logistic regression was used to examine in the United States the association between maternal outcomes (severe maternal morbidity, mortality, failure-to-rescue, and cesarean delivery) and the weekly hospital proportion of COVID-19 patients, and the interaction between race, ethnicity, payer status, and the hospital COVID-19 burden using US national data from the Vizient Clinical Database between 2017 and 2022.

RESULTS:
Among 2484,895 admissions for delivery, 457,992 (18.4%) were non-Hispanic Black (hereafter referred to as Black), 537,867 (21.7% were Hispanic), and 1489,036 (59.9%) were non-Hispanic White (hereafter referred to as White); mean (standard deviation [SD]) age, 29.9 (5.8). Mortality (adjusted odds ratio [AOR], 2.72; 95% confidence interval [CI], 1.28–5.8; P = .01) and failure-to-rescue (AOR, 2.89; 95% CI, 1.36–6.13, P = .01), increased during weeks with a COVID-19 burden of 10.1% to 20.0%, while rates of severe maternal morbidity and cesarean delivery were unchanged. Compared to White patients, Black and Hispanic patients had higher rates of severe maternal morbidity ([Black: OR, 1.97; 95% CI, 1.85–2.11, P < .001]; [Hispanic: OR, 1.37;95% CI, 1.28–1.48, P < .001]), mortality ([Black: OR, 1.92; 95% CI, 1.29–2.86, P < .001]; [Hispanic: OR, 1.51;95% CI, 1.01–2.24, P = .04]), and cesarean delivery ([Black: OR, 1.58; 95% CI, 1.54–1.63, P < .001]; [Hispanic: OR, 1.09;95% CI, 1.05–1.13, P < .001]), but not failure-to-rescue. Except for Black patients without insurance (1.3% of the patients), the pandemic was not associated with increases in maternal disparities. Odds of mortality (AOR, 1.96; 95% CI, 1.22–3.16, P = .01) and failure-to-rescue (AOR, 3.67; 95% CI, 1.67–8.07, P = .001) increased 2.0 and 3.7-fold, respectively, in Black patients without insurance compared to White patients with private insurance for each 10% increase in the weekly hospital COVID-19 burden.

CONCLUSIONS:
In this national study of 2.5 million deliveries in the United States, the COVID-19 pandemic was associated with increases in maternal mortality and failure-to-rescue but not in severe maternal morbidity or cesarean deliveries. While the pandemic did not exacerbate disparities for Black and Hispanic patients with private or Medicaid insurance, uninsured Black patients experienced greater increases in mortality and failure-to-rescue compared to insured White patients.
La moral pública y el Estado en Paraguay a mediados del siglo XIX
Authors: Potthast Barbara 
Published: January 2025

En este artículo, debatimos el carácter del Estado paraguayo a mediados del siglo XIX bajo la perspectiva de su política administrativa y sociocultural a partir de regulaciones estatales, pleitos judiciales y datos demográficos. Analizamos la voluntad del presidente Carlos Antonio López de reconstruir el poder de la Iglesia y de hacer de esta un agente importante en su objetivo de fortalecer el Estado patriarcal. Su intento de mejorar la «moral pública» y el comportamiento sexual de la población no tuvo, sin embargo, mucho éxito. No obstante, los altos números de hijos ilegítimos y de mujeres cabeza de familia no desmienten el carácter patriarcal de las estructuras familiares y de la sociedad paraguaya.
Fabrication of micro-bulge structures by a chemically assisted spatially shaped femtosecond laser and investigation of their surface anti-icing performance
Authors: Wang Yang , Wang Qian , Yuan Yanping 
Published: January 2025

To address the anti-icing performance requirements of superhydrophobic surfaces, this study adopts a manufacturing method that combines Bessel femtosecond laser and chemical modification techniques to fabricate a superhydrophobic micro-protrusion structure on a nickel-based high-temperature alloy surface. The micro-protrusion structure consists of micro-scale elevations and nano-scale wrinkles, which results in a contact angle as high as 152.4∘±0.1∘. This allows the static freezing time of the surface to be extended from 31 to 228 s, which is 7.3 times longer than the untreated nickel-based alloy sample. This is because the micro-protrusion structure, in collaboration with the silanization modification technique, significantly reduces the surface-free energy of the material, which can effectively regulate the wettability of the material surface, transitioning it from hydrophilic to superhydrophobic. This study provides a new approach for anti-icing technology, to our knowledge, that can be widely applied in the fields of energy, military, and aerospace.
Polarization beam splitter based on a double-groove slanted grating under normal incidence
Authors: Wang Yi-han , Wang Jin , Chen Yu-da , Huang Zhi-sen , Jia Wei , Zhou Chang-he 
Published: January 2025

In this paper, we propose a one-dimensional polarization beam splitting grating under normal incidence with excellent polarization characteristics and a high diffraction efficiency. The main structure is a double-groove slanted grating. We employed a rigorous coupled-wave analysis and simulated annealing algorithm for numerical calculations of the grating. The optimized grating structure can concentrate the energy of TE-polarized light at the −1st order and the energy of TM-polarized light at the 0th order under normal incidence. The analysis results indicate that at the incident wavelength of 1550 nm, the diffraction efficiency is 93.549% for TE polarization and 93.522% for TM polarization, with an extinction ratio greater than 14 dB. To the best of our knowledge, this is the first report of a one-dimensional polarization beam splitter grating with a transmissive double-groove slanted grating under normal incidence. This grating shows great potential for applications in polarization measurement, imaging, and grating encoders.