bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transcriptomics-driven drug repositioning for the treatment of diabetic foot ulcer
Authors: Adikusuma Wirawan , Zakaria Zainul Amiruddin , Irham Lalu Muhammad , Nopitasari Baiq Leny , Pradiningsih Anna , Firdayani Firdayani , Septama Abdi Wira , Chong Rockie 
Published: June 2023

AbstractDiabetic foot ulcers (DFUs) are a common complication of diabetes and can lead to severe disability and even amputation. Despite advances in treatment, there is currently no cure for DFUs and available drugs for treatment are limited. This study aimed to identify new candidate drugs and repurpose existing drugs to treat DFUs based on transcriptomics analysis. A total of 31 differentially expressed genes (DEGs) were identified and used to prioritize the biological risk genes for DFUs. Further investigation using the database DGIdb revealed 12 druggable target genes among 50 biological DFU risk genes, corresponding to 31 drugs. Interestingly, we highlighted that two drugs (urokinase and lidocaine) are under clinical investigation for DFU and 29 drugs are potential candidates to be repurposed for DFU therapy. The top 5 potential biomarkers for DFU from our findings are IL6ST, CXCL9, IL1R1, CXCR2, and IL10. This study highlights IL1R1 as a highly promising biomarker for DFU due to its high systemic score in functional annotations, that can be targeted with an existing drug, Anakinra. Our study proposed that the integration of transcriptomic and bioinformatic-based approaches has the potential to drive drug repurposing for DFUs. Further research will further examine the mechanisms by which targeting IL1R1 can be used to treat DFU.
Fabrication of Schottky barrier diodes utilizing carboxylate bridged trinuclear mixed valence cobalt(iii/ii/iii) complexes of tetradentate N2O2donor reduced Schiff base ligands
Authors: Bhunia Sudip , Das Pubali , Banerjee Snehasis , Gomila Rosa M. , Drew Michael G. B. , Frontera Antonio , Ray Partha Pratim , Chattopadhyay Shouvik 
Published: June 2023

The band gaps in three new mixed valence trinuclear cobalt complexes in their solid state have been determined experimentally and also by DFT calculation. The complexes have been used to fabricate Schottky barrier diodes.
Sensitivity to Semantic Relationships in U.S. Monolingual English-Speaking Typical Talkers and Late Talkers
Authors: Curtis Philip R. , Estabrook Ryne , Roberts Megan Y. , Weisleder Adriana 
Published: June 2023

Purpose:
Late talkers (LTs) are a group of children who exhibit delays in language development without a known cause. Although a hallmark of LTs is a reduced expressive vocabulary, little is known about LTs' processing of semantic relations among words in their emerging vocabularies. This study uses an eye-tracking task to compare 2-year-old LTs' and typical talkers' (TTs') sensitivity to semantic relationships among early acquired words.

Method:

U.S. monolingual English-speaking LTs (
n
= 21) and TTs (
n
= 24) completed a looking-while-listening task in which they viewed two images on a screen (e.g., a shirt and a pizza), while they heard words that referred to one of the images (e.g.,
Look! Shirt!
; target-present condition) or a semantically related item (e.g.,
Look! Hat!
; target-absent condition). Children's eye movements (i.e., looks to the target) were monitored to assess their sensitivity to these semantic relationships.

Results:
Both LTs and TTs looked longer at the semantically related image than the unrelated image on target-absent trials, demonstrating sensitivity to the taxonomic relationships used in the experiment. There was no significant group difference between LTs and TTs. Both groups also looked more to the target in the target-present condition than in the target-absent condition.

Conclusions:
These results reveal that, despite possessing smaller expressive vocabularies, LTs have encoded semantic relationships in their receptive vocabularies and activate these during real-time language comprehension. This study furthers our understanding of LTs' emerging linguistic systems and language processing skills.

Supplemental Material:

https://doi.org/10.23641/asha.23303987
Code-Switching During Narratives by Bilingual Children With and Without Developmental Language Disorder
Authors: Gross Megan C. , Castilla-Earls Anny 
Published: June 2023

Purpose:
This study examined the frequency, direction, and structural characteristics of code-switching (CS) during narratives by Spanish–English bilingual children with and without developmental language disorder (DLD) to determine whether children with DLD exhibit unique features in their CS that may inform clinical decision-making.

Method:

Spanish–English bilingual children, aged 4;0–6;11 (years;months), with DLD (
n
= 33) and with typical language development (TLD;
n
= 33) participated in narrative retell and story generation tasks in Spanish and English. Instances of CS were classified as between utterance or within utterance; within-utterance CS was coded for type of grammatical structure. Children completed the morphosyntax subtests of the Bilingual English-Spanish Assessment to assist in identifying DLD and to index Spanish and English morphosyntactic proficiency.

Results:
In analyses examining the contributions of both DLD status and Spanish and English proficiency, the only significant effect of DLD was on the tendency to engage in between-utterance CS; children with DLD were more likely than TLD peers to produce whole utterances in English during the Spanish narrative task. Within-utterance CS was related to lower morphosyntax scores in the target language, but there was no effect of DLD. Both groups exhibited noun insertions as the most frequent type of within-utterance CS. However, children with DLD tended to exhibit more determiner and verb insertions than TLD peers and increased use of “congruent lexicalization,” that is, CS utterances that integrate content and function words from both languages.

Conclusions:
These findings reinforce that use of CS, particularly within-utterance CS, is a typical bilingual behavior even during narrative samples collected in a single-language context. However, language difficulties associated with DLD may emerge in how children code-switch, including use of between-utterance CS and unique patterns during within-utterance CS. Therefore, analyzing CS patterns may contribute to a more complete profile of children's dual-language skills during assessment.

Supplemental Material:

https://doi.org/10.23641/asha.23479574
Disparities in Health Care Utilization Among Deaf and Hard of Hearing Adults
Authors: Gonzalez Valeria C. , Santiago Zulma Y. , Jacobs Molly , Ellis Charles 
Published: June 2023

Purpose:
A substantial literature exists, documenting differences in access to quality health care among individuals of different racial/ethnic, residence, income, and disability groups. However, little attention has been given to disparate utilization among those who are deaf or hard of hearing (DHH). The purpose of this study was to evaluate differences between individuals with and without hearing-related issues using a nationally representative survey of health care access outcomes to quantify the magnitude of these differences.

Method:
Using data from the 2021 Centers for Disease Control Behavioral Risk Factor Surveillance System survey, we compared health care utilization between individuals who reported being DHH and those without hearing-related issues. Logistic regression models were used to explore differences in access to care between DHH and non-DHH individuals controlling for sociodemographic characteristics.

Results:

The total Behavioral Risk Factor Surveillance System survey sample consisted of 412,427 respondents. Among those were 36,532 (6.85%) who identified as DHH. Logistic models indicated that DHH adults were less likely to have a personal health care provider (odds ratio [
OR
] = 0.91, 95% CI [0.83–2.03]) and less likely to have received a routine checkup within the last 2 years (
OR
= 0.91, 95% CI [0.82–1.02]) but more likely to have forgone health care due to difficulty paying (
OR
= 1.90, 95% CI [1.71–2.06]) compared to those without hearing difficulties. Differences were robust to race, sex, and other demographic factors.

Conclusions:
Significant differences in health care utilization were observed between DHH and non-DHH individuals. This is concerning given that DHH adults have a higher prevalence of many chronic conditions that require clinical management. These results indicate that health care providers and systems must offer greater communication options to facilitate better health-related outcomes.
Optimized hybrid YOLOu‐Quasi‐ProtoPNet for insulators classification
Authors: Stefenon Stefano Frizzo , Singh Gurmail , Souza Bruno José , Freire Roberto Zanetti , Yow Kin‐Choong 
Published: June 2023

AbstractTo ensure the electrical power supply, inspections are frequently performed in the power grid. Nowadays, several inspections are conducted considering the use of aerial images since the grids might be in places that are difficult to access. The classification of the insulators' conditions recorded in inspections through computer vision is challenging, as object identification methods can have low performance because they are typically pre‐trained for a generalized task. Here, a hybrid method called YOLOu‐Quasi‐ProtoPNet is proposed for the detection and classification of failed insulators. This model is trained from scratch, using a personalized ultra‐large version of YOLOv5 for insulator detection and the optimized Quasi‐ProtoPNet model for classification. For the optimization of the Quasi‐ProtoPNet structure, the backbones VGG‐16, VGG‐19, ResNet‐34, ResNet‐152, DenseNet‐121, and DenseNet‐161 are evaluated. The F1‐score of 0.95165 was achieved using the proposed approach (based on DenseNet‐161) which outperforms models of the same class such as the Semi‐ProtoPNet, Ps‐ProtoPNet, Gen‐ProtoPNet, NP‐ProtoPNet, and the standard ProtoPNet for the classification task.
Coordinated multi‐agent hierarchical deep reinforcement learning to solve multi‐trip vehicle routing problems with soft time windows
Authors: Zhang Zixian , Qi Geqi , Guan Wei 
Published: June 2023

AbstractVehicle Routing Problem (VRP) is a widespread problem in the transportation field, which challenges the intelligent level of vehicle decisions. Multi‐Trip Vehicle Routing Problem with Time Windows (MTVRPTW), as a further evolved problem of VRP considering multiple departures from one depot and temporal constraint of visiting nodes, has developed into one of the critical issues in the scheduling of logistics, bus transit, railway, and aviation. Traditionally, MTVRPTW is solved by the heuristic algorithm, which is generally time‐consuming and of non‐steady results. Reinforcement learning (RL) and multi‐agent framework have become popular in solving VRP to get better performance. However, the lack of variant dimensions in searching space and knowledge exchange between agents inhibit the further improvement of algorithms. Therefore, a Coordinated Multi‐agent Hierarchical Deep Reinforcement Learning (CMA‐HDRL) method is proposed in this study to enhance the overall solution quality and convergence rate by constructing a three‐layered structure (time, communication, and global layers), which is particularly designed to handle the state space explosion and improve the collaboration between agents. The results show that the proposed method can significantly outperform the general genetic algorithm (GA), RL, multi‐agent algorithm, and hierarchical algorithm, not only from the effectiveness on the cost consisting of travel time and penalty time but also from the operation robustness.
Advanced Midwifery Practice
Authors: Krahl Astrid 
Published: June 2023

Theorie trifft PraxisDie Akademisierung der Ausbildung zur Hebamme ist in Deutschland erreicht. Mit dem
Bachelorabschluss werden nun weitere akademische Entwicklungsmöglichkeiten
eröffnet. Üblicherweise können dies Studiengänge
sein, die speziell für Management- und Lehrtätigkeiten oder eine
akademische Karriere in Forschung und Wissenschaft qualifizieren. Doch welche
akademischen Entwicklungschancen und Karrierewege sollte es für Hebammen
geben, die gerne weiterhin mit Frauen, ihren Kindern und Familien arbeiten
wollen?
Erstvorstellung des Pentafecta-Scores als Qualitätsinstrument der Outcome-Bewertung einer chirurgischen Primärtherapie an Patienten mit Peniskarzinom
Authors: May Matthias , Lebentrau Steffen , Ayres Ben , Spiess Philippe E. , Watkin Nick , Albersen Maarten , Protzel Chris , Chahoud Jad , Brouwer Oscar R. , Pettaway Curtis A. , Pagliaro Lance C. , Necchi Andrea , Hakenberg Oliver W. 
Published: June 2023

Zusammenfassung
Hintergrund Aktuell wurde mit dem Tetrafecta-Score das erste Instrument zur Beurteilung der Behandlungsqualität in der chirurgischen Primärtherapie des Peniskarzinoms (PECa) publiziert. Eine externe wissenschaftliche Auseinandersetzung mit den ihn definierenden Einzelkriterien steht bislang noch aus und bildet das Studienziel.

Material und Methode Es wurde eine internationale Arbeitsgruppe bestehend aus 12 Urologen und einem Onkologen mit klinischer und akademisch-wissenschaftlicher Expertise auf dem Gebiet des Peniskarzinoms gegründet. In einem modifizierten vierstufigen Delphi-Prozess wurden unter Einbeziehung der Tetrafecta-Kriterien insgesamt 13 Kriterien für PECa-Patienten in den klinischen AJCC-Stadien 1–4 (T1–3N0–3, aber M0) definiert, von denen in einer geheimen Abstimmung jeder der Experten 5 auswählen musste, um dadurch einen individuellen Pentafecta-Score zu generieren. Anschließend wurde das Rating der Experten aggregiert ausgewertet und dadurch ein finaler Pentafecta-Score gebildet.

Ergebnisse Keines der ursprünglichen Tetrafecta-Kriterien wurde in den finalen Pentafecta-Score übernommen, der sich aus den folgenden Kriterien zusammensetzt: 1.) Organerhalt, sofern immer möglich (≤T2), jedoch stets unter Wahrung eines negativen chirurgischen Schnittrandes, 2.) beidseitige inguinale Lymphadenektomie (ILAE) ab pT1G2N0, 3.) perioperative Chemotherapie sollte erfolgen, sofern durch die Leitlinien indiziert, 4.) ILAE sollte, sofern indiziert, in einem zeitlichen Abstand von maximal 3 Monaten zur Primärtumorresektion erfolgen und 5.) die behandelnde Klinik sollte im Minimum 15 chirurgische Primärtherapien bei PECa-Patienten durchführen. Nur 7 der 13 Experten (54%) zeigten eine starke Korrelation ihres individuellen mit dem finalen Pentafecta-Score (rsp >0.60).

Schlussfolgerung Auf der Basis eines moderierten Abstimmungsprozesses unter internationalen PECa-Experten wurde ein Pentafecta-Score als Qualitätssicherungs-Instrument für die chirurgische Primärtherapie gebildet, der nun anhand von patientenrelevanten und patientenberichteten Endpunkten zu validieren ist.
A Prospective Study of Social Needs Associated with Mental Health among Postpartum Patients Living in Underserved Communities
Authors: Lafferty Ashlyn K. , Duryea Elaine , Martin Robert , Moseley Lisa , Lopez Melissa , McIntire Donald D. , Spong Catherine Y. , Nelson David B. 
Published: June 2023

Objective Given the rising rates of maternal morbidity and mortality in the United States and the contribution of mental illness, especially among individuals living in underresourced communities, the objective was to evaluate the prevalence of unmet health-related social needs and their impact on perinatal mental health outcomes.
Study Design This was a prospective observational study of postpartum patients residing within regions with increased rates of poor perinatal outcomes and sociodemographic disparities. Patients were enrolled in a multidisciplinary public health initiative “extending Maternal Care After Pregnancy (eMCAP)” between October 1, 2020 and October 31, 2021. Unmet health-related social needs were assessed at delivery. Symptoms of postpartum depression and anxiety were evaluated at 1 month postpartum utilizing the Edinburgh Postnatal Depression Scale (EPDS) and Generalized Anxiety Disorder-7 (GAD7) screening tools, respectively. Mean EPDS and GAD7 scores and odds of screening positive (scoring ≥ 10) were compared among individuals with and without unmet health-related social needs with p < 0.05 considered significant.
Results Of participants enrolled in eMCAP, 603 completed at least one EPDS or GAD7 at 1 month. Most had at least one social need, most commonly dependence on social programs for food (n = 413/603; 68%). Individuals lacking transportation to medical (odds ratio [OR]: 4.0, 95% confidence interval [CI]: 1.2–13.32) and nonmedical appointments (OR: 4.17, 95% CI: 1.08–16.03) had significantly higher odds of screening positive on EPDS while participants lacking transportation to medical appointments (OR: 2.73, 95% CI: 0.97–7.70) had significantly higher odds of screening positive on GAD7.
Conclusion Among postpartum individuals in underserved communities, social needs correlate with higher depression and anxiety screening scores. This highlights the need to address social needs to improve maternal mental health.
Key Points
Bewegungskontrolle und Bewegungsdysfunktion (2) Tests und Übungen für die Körperwahrnehmung
Authors: Luomajoki Hannu 
Published: June 2023

ZusammenfassungNeben aktivem Training empfiehlt es sich, die Körperwahrnehmung von Patient*innen mit Rückenschmerzen einzuschätzen und gegebenenfalls zu verbessern.
Development of an accurate optical sensor for the in situ real-time determination of the chemical oxygen demand of seawater
Authors: Liu Jialiang , Ma Haikuan , Yuan Guang , Wang Zhaoyu , Ma Ran , Zhang Shuwei , Cao Xuan , Wang Yang , Liu Yan 
Published: June 2023

Chemical oxygen demand (COD) is an important indicator for monitoring the quality of seawater. The COD of seawater reflects the levels of organic pollutants in the water. Methods that are commonly used to measure the COD of seawater have high accuracy, good repeatability, and low costs. However, using them for the in situ real-time monitoring of the COD of seawater is unfavorable because they require complex procedures and a long measurement time and may cause pollution to the environment. This paper reports on an optical sensor that accurately determines the COD of seawater in situ. The COD determination is based on the absorption of ultraviolet and visible lights with different wavelengths by organic matter in the water. Single-point LEDs emitting lights with different wavelengths (254, 265, 280, and 546 nm) were used as sources of excitation lights, and photodiodes were used as receiving devices. The optical system, circuit system, and mechanical structure of the sensor were efficiently integrated. The inversion of the COD of seawater was obtained after turbidity correction using the multiple linear regression algorithm. The maximum measurement error, detection limit, and repeatability of the sensor were 5%, 0.05 mg/l, and 0.62%, respectively. Moreover, the R2 values for correlations between COD values and absorbance values measured at three wavelengths (254, 265, and 280 nm) were above 0.99. Overall, the sensor is suitable for the in situ real-time monitoring of the COD of seawater. It requires a short measurement time and generates no pollution.
Development of a resonant screw-driven piezoelectric motor operating in single-mode vibration
Authors: Pan Qiaosheng , Wang Ya , Wan Aode , Zhao Mingfei , Li Chen , Li Ruijun 
Published: June 2023

A resonant screw-driven piezoelectric motor operating in single-mode vibrations is proposed, designed, manufactured, and studied. The motor is constructed with a stator and a threaded rotor. The stator consists of a hollow parallelogram metal elastomer and two piezoelectric ceramic plates. The motor is excited by a single-phase signal to produce two separate vibration modes: the first expansion mode (B1 mode) and the second expansion mode (B2 mode). Each mode drives the threaded rotor in one direction, and the bidirectional motion is achieved by switching the two modes. The construction is designed, and modal simulation is performed using finite element software to determine the structural parameters. A frequency-domain analysis is performed to obtain the frequency response characteristics, and the motion trajectories of the stator are obtained using transient analysis. Finally, a prototype is produced, and experiments are conducted. Experimental results indicate that the no-load speeds of the motor under the 200 Vp-p voltage excitation are 1.67 and 1.04 mm/s in the two modes, which correspond to maximum loads of 35 and 20 mN, respectively.
Role of the single-particle dynamics in the transverse current autocorrelation function of a liquid metal
Authors: Guarini Eleonora , Bafile Ubaldo , Colognesi Daniele , Cunsolo Alessandro , De Francesco Alessio , Formisano Ferdinando , Montfrooij Wouter , Neumann Martin , Barocchi Fabrizio 
Published: June 2023

A recent simulation study of the transverse current autocorrelation of the Lennard-Jones fluid [Guarini et al., Phys. Rev. E 107, 014139 (2023)] revealed that this function can be perfectly described within the exponential expansion theory [Barocchi et al., Phys. Rev. E 85, 022102 (2012)]. However, above a certain wavevector Q, not only transverse collective excitations were found to propagate in the fluid, but a second oscillatory component of unclear origin (therefore called X) must be considered to fully account for the time dependence of the correlation function. Here, we present an extended investigation of the transverse current autocorrelation of liquid Au as obtained by ab initio molecular dynamics in the very wide range of wavevectors 5.7 ≤ Q ≤ 32.8 nm−1 in order to also follow the behavior of the X component, if present, at large Q values. A joint analysis of the transverse current spectrum and its self-portion indicates that the second oscillatory component arises from the longitudinal dynamics, as suggested by its close resemblance with the previously determined component accounting for the longitudinal part of the density of states. We conclude that such a mode, albeit featuring a merely transverse property, fingerprints the effect of longitudinal collective excitations on single-particle dynamics, rather than arising from a possible coupling between transverse and longitudinal acoustic waves.
Severe, large-scale bushfire threatens metapopulation function of quokka (Setonix brachyurus) in south-western Australia
Authors: Bain Karlene , Halley Merril , Wayne Adrian 
Published: June 2023

Background The risk of large, severe bushfires is increasing in Australia, and little is known about their impact on threatened species. Aims This study aimed to investigated the abundance, occupancy and metapopulation structure of the quokka (Setonix brachyurus) for 5 years following a large, severe bushfire in Western Australia. Methods Data collected across spatiotemporally replicated transects were used to estimate probabilities of occupancy and abundance, and to evaluate the influence of covariates. Key results Quokka abundance was reduced to 16% of pre-fire levels, with distances up to 74 km separating subpopulations. Recolonising quokkas occupied habitat in parts of the landscape that had retained some vertical vegetation structure and contained a sedge-dominated understorey, and where damage by feral pigs was low. This coincided with topographic refugia that consisted of deep, mesic riparian systems or perched wetland systems. After 5 years, abundance had increased to 46% of pre-fire levels, with distances of 5–30 km separating subpopulations. Conclusion Quokka recovery rate is slower than expected, and the metapopulation remains vulnerable to further fragmentation arising from disturbances that affect habitat patch suitability and movement corridors. Implications Proactive protection of refugia and spatiotemporal habitat connectivity within and surrounding the fire scar is critical for metapopulation recovery.