bluuebunny/crossref_metadata_2025_split huggingface dataset:
Resurfacing History and Volcanic Activity of Venus
Authors: Herrick Robert R. , Bjonnes Evan T. , Carter Lynn M. , Gerya Taras , Ghail Richard C. , Gillmann Cédric , Gilmore Martha , Hensley Scott , Ivanov Mikhail A. , Izenberg Noam R. , Mueller Nils T. , O’Rourke Joseph G. , Rolf Tobias , Smrekar Suzanne E. , Weller Matthew B. 
Published: April 2023

AbstractPhotogeologic principles can be used to suggest possible sequences of events that result in the present planetary surface. The most common method of evaluating the absolute age of a planetary surface remotely is to count the number of impact craters that have occurred after the surface formed, with the assumption that the craters occur in a spatially random fashion over time. Using additional assumptions, craters that have been partially modified by later geologic activity can be used to assess the time frames for an interpreted sequence of events. The total number of craters on Venus is low and the spatial distribution taken by itself is nearly indistinguishable from random. The overall implication is that the Venusian surface is much closer to Earth in its youthfulness than the other, smaller inner solar system bodies. There are differing interpretations of the extent to which volcanism and tectonics have modified the craters and of the regional and global sequences of geologic events. Consequently, a spectrum of global resurfacing views has emerged. These range from a planet that has evolved to have limited current volcanism and tectonics concentrated in a few zones to a planet with Earth-like levels of activity occurring everywhere at similar rates but in different ways. Analyses of the geologic record have provided observations that are challenging to reconcile with either of the endmember views. The interpretation of a global evolution with time in the nature of geologic activity relies on assumptions that have been challenged, but there are other observations of areally extensive short-lived features such as canali that are challenging to reconcile with a view of different regions evolving independently. Future data, especially high-resolution imaging and topography, can provide the details to resolve some of the issues. These different global-evolution viewpoints must tie to assessments of present-day volcanic and tectonic activity levels that can be made with the data from upcoming missions.
An objection to the modal account of risk
Authors: Smith Martin 
Published: April 2023

AbstractIn a recent paper in this journal Duncan Pritchard responds to an objection to the modal account of risk pressed by Ebert, Smith and Durbach (2020). In this paper, I expand upon the objection and argue that it still stands. I go on to consider a more general question raised by this exchange – whether risk is ‘objective’, or whether it is something that varies from one perspective to another.
Experimental validation of computer-vision methods for the successful detection of endodontic treatment obturation and progression from noisy radiographs
Authors: Hasan Habib Al , Saad Farhan Hasin , Ahmed Saif , Mohammed Nabeel , Farook Taseef Hasan , Dudley James 
Published: April 2023

AbstractPurpose(1) To evaluate the effects of denoising and data balancing on deep learning to detect endodontic treatment outcomes from radiographs. (2) To develop and train a deep-learning model and classifier to predict obturation quality from radiomics.MethodsThe study conformed to the STARD 2015 and MI-CLAIMS 2021 guidelines. 250 deidentified dental radiographs were collected and augmented to produce 2226 images. The dataset was classified according to endodontic treatment outcomes following a set of customized criteria. The dataset was denoised and balanced, and processed with YOLOv5s, YOLOv5x, and YOLOv7 models of real-time deep-learning computer vision. Diagnostic test parameters such as sensitivity (Sn), specificity (Sp), accuracy (Ac), precision, recall, mean average precision (mAP), and confidence were evaluated.ResultsOverall accuracy for all the deep-learning models was above 85%. Imbalanced datasets with noise removal led to YOLOv5x’s prediction accuracy to drop to 72%, while balancing and noise removal led to all three models performing at over 95% accuracy. mAP saw an improvement from 52 to 92% following balancing and denoising.ConclusionThe current study of computer vision applied to radiomic datasets successfully classified endodontic treatment obturation and mishaps according to a custom progressive classification system and serves as a foundation to larger research on the subject matter.
Maternal environmental, occupational, and urinary metabolite levels of benzene compounds and their association with congenital heart diseases in offspring: a case‒control study in China
Authors: Wang Meixian , Li Lu , Kang Hong , Xu Hongmei , Huang Qian , Li Nana , Deng Ying , Yu Ping , Liu Zhen 
Published: April 2023

AbstractThe conclusions about the association of maternal pregnancy environment, occupation, and benzene compounds with fetal CHD are not entirely consistent. Eight hundred seven CHD cases and 1008 controls were included in this study. All occupations were classified and coded against the Occupational Classification Dictionary of the People’s Republic of China (2015 version). Logistic regressions were used to explore the correlation among environmental factors, occupation types, and CHDs in offspring. We found that living near public facilities and having exposure to chemical reagents and hazardous substances were significant risk factors for CHDs in offspring. We found that offspring of mothers who worked in agriculture and similar work during pregnancy suffered from CHD. The risk of all CHDs in the offspring of pregnant women working in production manufacturing and related work was significantly higher than that in unemployed pregnant women, the risk was also observed in 4 subtypes of CHDs. We compared the concentrations of the five metabolite (MA, mHA, HA, PGA, and SPMA) levels of benzene compounds in the urine of mothers in case and control groups and found no significant differences. Our study suggests that maternal exposure during pregnancy and certain environmental and occupational conditions are risk factors for CHD in offspring, but did not support an association between concentrations of metabolites of benzene compounds in the urine of pregnant women and CHDs in their offspring.
Modelling Radiation Cancer Treatment with a Death-Rate Term in Ordinary and Fractional Differential Equations
Authors: Wilson Nicole , Drapaca Corina S. , Enderling Heiko , Caudell Jimmy J. , Wilkie Kathleen P. 
Published: April 2023

AbstractFractional calculus has recently been applied to the mathematical modelling of tumour growth, but its use introduces complexities that may not be warranted. Mathematical modelling with differential equations is a standard approach to study and predict treatment outcomes for population-level and patient-specific responses. Here, we use patient data of radiation-treated tumours to discuss the benefits and limitations of introducing fractional derivatives into three standard models of tumour growth. The fractional derivative introduces a history-dependence into the growth function, which requires a continuous death-rate term for radiation treatment. This newly proposed radiation-induced death-rate term improves computational efficiency in both ordinary and fractional derivative models. This computational speed-up will benefit common simulation tasks such as model parameterization and the construction and running of virtual clinical trials.
Hairy Cell Leukemia: Where Are We in 2023?
Authors: Mendez-Hernandez Andres , Moturi Krishna , Hanson Valeria , Andritsos Leslie A. 
Published: April 2023

Abstract

Purpose of Review
This article summarizes the current state of knowledge of hairy cell leukemia (HCL) regarding presentation, diagnosis, therapy, and monitoring, including perspectives on emergent therapies.

Recent Findings
Over the past decade, there has been enormous progress in the understanding of the biology of HCL which has led to the development of novel therapeutic strategies. The maturation of data regarding existing management strategies has also lent considerable insight into therapeutic outcomes and prognosis of patients treated with chemo- or chemoimmunotherapy. Purine nucleoside analogs remain the cornerstone of treatment, and the addition of rituximab has deepened and prolonged responses in the upfront and relapsed setting. Targeted therapies now have a more defined role in the management of HCL, with BRAF inhibitors now having a potential in the first-line setting in selected cases as well as in relapse. Next-generation sequencing for the identification of targetable mutations, evaluation of measurable residual disease, and risk stratification continue to be areas of active investigation.

Summary
Recent advances in HCL have led to more effective therapeutics in the upfront and relapsed setting. Future efforts will focus on identifying patients with high-risk disease who require intensified regimens. Multicenter collaborations are the key to improving overall survival and quality of life in this rare disease.
A Taxonomy for Research Integrity Training: Design, Conduct, and Improvements in Research Integrity Courses
Authors: van den Hoven Mariëtte , Lindemann Tom , Zollitsch Linda , Prieß-Buchheit Julia 
Published: April 2023

AbstractTrainers often use information from previous learning sessions to design or redesign a course. Although universities conducted numerous research integrity training in the past decades, information on what works and what does not work in research integrity training are still scattered. The latest meta-reviews offer trainers some information about effective teaching and learning activities. Yet they lack information to determine which activities are plausible for specific target groups and learning outcomes and thus do not support course design decisions in the best possible manner. This article wants to change this status quo and outlines an easy-to-use taxonomy for research integrity training based on Kirkpatrick’s four levels of evaluation to foster mutual exchange and improve research integrity course design. By describing the taxonomy for research integrity training (TRIT) in detail and outlining three European projects, their intended training effects before the project started, their learning outcomes, teaching and learning activities, and their assessment instruments, this article introduces a unified approach. This article gives practitioners references to identify didactical interrelations and impacts and (knowledge) gaps in how to (re-)design an RI course. The suggested taxonomy is easy to use and enables an increase in tailored and evidence-based (re-)designs of research integrity training.
Research Ethics in the Age of Digital Platforms
Authors: Molina José Luis , Tubaro Paola , Casilli Antonio , Santos-Ortega Antonio 
Published: April 2023

AbstractScientific research is growingly increasingly reliant on "microwork" or "crowdsourcing" provided by digital platforms to collect new data. Digital platforms connect clients and workers, charging a fee for an algorithmically managed workflow based on Terms of Service agreements. Although these platforms offer a way to make a living or complement other sources of income, microworkers lack fundamental labor rights and basic safe working conditions, especially in the Global South. We ask how researchers and research institutions address the ethical issues involved in considering microworkers as "human participants." We argue that current scientific research fails to treat microworkers in the same way as in-person human participants, producing de facto a double morality: one applied to people with rights acknowledged by states and international bodies (e.g., the Helsinki Declaration), the other to guest workers of digital autocracies who have almost no rights at all. We illustrate our argument by drawing on 57 interviews conducted with microworkers in Spanish-speaking countries.
Rat Hair Metabolomics Analysis Reveals Perturbations of Unsaturated Fatty Acid Biosynthesis, Phenylalanine, and Arachidonic Acid Metabolism Pathways Are Associated with Amyloid-β-Induced Cognitive Deficits
Authors: Tan Tian-Hoe , Li Shih-Wen , Chang Chih-Wei , Chen Yuan-Chih , Liu Yu-Hsuan , Ma Jui-Ti , Chang Ching-Ping , Liao Pao-Chi 
Published: April 2023

AbstractHair is a noninvasive valuable biospecimen for the long-term assessment of endogenous metabolic disturbance. Whether the hair is suitable for identifying biomarkers of the Alzheimer’s disease (AD) process remains unknown. We aim to investigate the metabolism changes in hair after β-amyloid (Aβ1-42) exposure in rats using ultra-high-performance liquid chromatography-high-resolution mass spectrometry–based untargeted and targeted methods. Thirty-five days after Aβ1-42 induction, rats displayed significant cognitive deficits, and forty metabolites were changed, of which twenty belonged to three perturbed pathways: (1) phenylalanine metabolism and phenylalanine, tyrosine, and tryptophan biosynthesis—l-phenylalanine, phenylpyruvate, ortho-hydroxyphenylacetic acid, and phenyllactic acid are up-regulated; (2) arachidonic acid (ARA) metabolism—leukotriene B4 (LTB4), arachidonyl carnitine, and 5(S)-HPETE are upregulation, but ARA, 14,15-DiHETrE, 5(S)-HETE, and PGB2 are opposite; and (3) unsaturated fatty acid biosynthesis— eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), FA 18:3 + 1O, and FA 18:3 + 2O are downregulated. Linoleic acid metabolism belonging to the biosynthesis of unsaturated fatty acid includes the upregulation of 8-hydroxy-9,10-epoxystearic acid, 13-oxoODE, and FA 18:2 + 4O, and downregulation of 9(S)-HPODE and dihomo-γ-linolenic acid. In addition, cortisone and dehydroepiandrosterone belonging to steroid hormone biosynthesis are upregulated. These three perturbed metabolic pathways also correlate with cognitive impairment after Aβ1-42 stimulation. Furthermore, ARA, DHA, EPA, l-phenylalanine, and cortisone have been previously implicated in the cerebrospinal fluid of AD patients and show a similar changing trend in Aβ1-42 rats’ hair. These data suggest hair can be a useful biospecimen that well reflects the expression of non-polar molecules under Aβ1-42 stimulation, and the five metabolites have the potential to serve as novel AD biomarkers.
Transjugular intrahepatic collateral-systemic shunt is effective for cavernous transformation of the portal vein with variceal bleeding
Authors: Tie Jun , Gou Xiaoyuan , He Chuangye , Li Kai , Yuan Xulong , Jia Wenyuan , Niu Jing , Han Na , Xu Jiao , Zhu Ying , Wang Wenlan 
Published: April 2023

Abstract
Background
The transjugular intrahepatic portal collateral-systemic shunt (transcollateral TIPS) is used to treat portal hypertension-related complications in patients with cavernous transformation of the portal vein (CTPV) and whose main portal vein cannot be recanalized. It is still not clear whether transcollateral TIPS can be as effective as portal vein recanalization–transjugular intrahepatic portosystemic shunt (PVR–TIPS). This study aimed to evaluate the efficacy and safety of transcollateral TIPS in the treatment of refractory variceal bleeding with CTPV.

Methods
Patients with refractory variceal bleeding caused by CTPV were selected from the database of consecutive patients treated with TIPS in Xijing Hospital from January 2015 to March 2022. They were divided into the transcollateral TIPS group and the PVR–TIPS group. The rebleeding rate, overall survival, shunt dysfunction, overt hepatic encephalopathy (OHE) and operation-related complications were analyzed.

Results
A total of 192 patients were enrolled, including 21 patients with transcollateral TIPS and 171 patients with PVR–TIPS. Compared with the patients with PVR–TIPS, the patients with transcollateral TIPS had more noncirrhosis (52.4 vs. 19.9%, p = 0.002), underwent fewer splenectomies (14.3 vs. 40.9%, p = 0.018), and had more extensive thromboses (38.1 vs. 15.2%, p = 0.026). There were no differences in rebleeding, survival, shunt dysfunction, or operation-related complication rates between the transcollateral TIPS and PVR–TIPS groups. However, the OHE rate was significantly lower in the transcollateral TIPS group (9.5 vs. 35.1%, p = 0.018).

Conclusion
Transcollateral TIPS is an effective treatment for CTPV with refractory variceal bleeding.
Adaptation across the Lifespan: Towards a Processual Evolutionary Explanation of Human Development
Authors: Greve Werner 
Published: April 2023

AbstractThis paper argues that the project of a lifespan perspective in developmental psychology has not yet been systematically pursued. Overall, the number of age-specific papers far outweighs the number of lifespan approaches, and even approaches that focus on the lifespan as a whole are often restricted to adulthood. Further, there is a lack of approaches that examine cross-lifespan relationships. However, the lifespan perspective has brought with it a "processual turn" that suggests an examination of developmental regulatory processes that are either operative across the lifespan or develop across the lifespan. Accommodative adjustment of goals and evaluations in response to obstacles, loss, and threat is discussed as an example of such a process. Not only is it prototypical of efficacy and change of developmental regulation across the lifespan, but at the same time it makes clear that stability (e.g., of the self)—as a possible outcome of accommodation—is not an alternative to, but a variant of development. Explaining how accommodative adaptation changes, in turn, requires a broader perspective. For this purpose, an evolutionary approach to developmental psychology is proposed that not only views human development as a product of phylogenesis, but also applies the central concepts of the theory of evolution (adaptation and history) directly to ontogeny. The challenges, conditions, and limitations of such a theoretical application of adaptation to human development are discussed.
Psychische und emotionale Erschöpfung von Fachkräften der Sozialen Arbeit
Authors: Kahl Yvonne , Bauknecht Jürgen 
Published: April 2023

ZusammenfassungDie psychische und emotionale Erschöpfung von Sozialarbeiter*innen wird längsschnittlich, im Vergleich mit anderen Berufsgruppen und innerhalb der Berufsgruppe im Alters- und Geschlechtsvergleich untersucht. Es zeigt sich eine psychische hohe Erschöpfung im Vergleich aller Beschäftigten, jedoch eine eher geringe psychische Erschöpfung im Vergleich der Sozialberufe, wobei die emotionale Erschöpfung ähnlich hoch ist. Wie in anderen Sozialberufen sind Frauen erschöpfter als Männer und junge Beschäftigte erschöpfter als jene im mittleren oder höheren Alter. Gezeigt werden Belastungsfaktoren der Überforderung und eines geringen Einflusses auf die Arbeitsmenge, sowie Resilienzfaktoren im Vergleich der Berufsgruppen. Hier nehmen Sozialarbeiter*innen im Vergleich aller Berufe eine hohe soziale Unterstützung im Kollegium wahr, während in der Unterstützung durch Vorgesetzte nur durchschnittliche Werte aller Berufsgruppen erreicht werden. Die Sozialarbeiter*innen werden in vier Gruppen kategorisiert, darunter die psychische und emotional besonders wenig sowie die besonders stark belastete Gruppe. Multivariat werden Faktoren ermittelt, die die Wahrscheinlichkeit der Zugehörigkeit zur besonders wenig belasteten Gruppe im Gegensatz zur besonders belasteten Gruppe verändern. Es zeigen sich in einem Modell mit hoher erklärter Varianz positive Effekte durch das Kollegium sowie durch Vorgesetzte und stark negative Effekte durch die qualitative und quantitative Überforderung. Das Gefühl, die eigene Tätigkeit sei wichtig, wirkt schwach negativ und kann nicht als Resilienzfaktor gelten. Die Kombination von hoher Erschöpfung in der jüngsten Gruppe, geringer subjektiver Unterstützung dieser Gruppe durch Kollegium und Vorgesetzte sowie die positive Wirkung dieser Unterstützung auf eine geringe Erschöpfung, legt nahe, dass sowohl die mentale Gesundheit junger Sozialarbeiter*innen sowie die Fachkräftesicherung von einer stärkeren Unterstützung dieser Gruppe profitieren könnte.
Assessment of Groundwater Potential Zone using Multi-criteria Decision-making Technique: A Case Study in the South-western Part of Yadadri Bhuvanagiri District, Telangana, India
Authors: Navitha K. , Madhusudan Rao B. , Sandhya R. 
Published: April 2023

Abstract
Groundwater which occurs beneath the earth’s surface is an important natural resource. The study area, part of Yadadri Bhuvanagiri district, Telangana, which is a part of Musi river basin, is a hard rock terrain covering an area of 1107 sq km, part of the eastern Dharwar craton (EDC) of the southern India peninsular shield. Exploration of groundwater in this terrain is difficult because groundwater is confined to weathered and fractured layers. The present study aims to delineate groundwater potential zones using the multi-criteria decision analysis (MCDA) technique. An integrated application of remote sensing and GIS is very effective in mapping features that provide information about groundwater potential zones using several thematic layers such as geology, soil, geomorphology, slope, lineament density, drainage density, rainfall, and land use/land cover maps. The groundwater potential zones of the study area are classified into five categories, namely very high, high, medium, low, and very low and they occupied an area of 116.8, 381.29, 345.15, 149.70, and 115.42 km2 respectively. The results were validated using discharge data from existing wells in the study area, and the majority of the high-productivity wells are located in very high and high groundwater potential zones. The groundwater potential zone mapping using this model will be a very useful improving the groundwater resources of the study area.
Deriving priority vector from pairwise comparisons matrix with fuzzy elements by solving optimization problem
Authors: Ramík Jaroslav 
Published: April 2023

AbstractPairwise comparisons matrix with fuzzy elements (FPCM) are appropriate for the decision makers who are uncertain about the relative importance of elements. We can primarily find them in Fuzzy Analytic Hierarchy Process, PROMETHEE, TOPSIS methods, and many exact and heuristic algorithms. They are also useful in aggregating pairwise comparisons, particularly in consensus group decision making problems and they form the basis for many decision-making models as intuitionistic fuzzy relations, pythagorean, q-rung orthopair fuzzy preference relations, hesitant or interval fuzzy sets, and also stochastic judgments. Here, the decision model is formulated by investigating pairwise comparisons matrices (PCMs) with elements from abelian linearly ordered group (alo-group), which enables unifying multiplicative, additive and fuzzy PCMs. Then we define a novel concept of consistency, coherence and intensity of FPCMs, and propose a number of optimization methods for finding a consistent vector, coherent vector and intensity vector of a FPCM satisfying the desirable properties. Finally, two illustrating examples are discussed.