bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anterior Cingulate Epilepsy: A Review
Authors: Pana Raluca M. , Nguyen Dang K. 
Published: March 2023

Summary:In this review, the semiology, and characteristics of noninvasive investigations suggestive of anterior cingulate and anterior midcingulate epilepsy are detailed by the authors. The clinical presentation is representative of a recently recognized rostrocaudal gradient of functional connectivity with seizures of the anterior cingulate cortex manifesting emotional and interoceptive aura followed by a hyperkinetic or complex motor seizures. The few reports of anterior midcingulate epilepsy show a trend toward a higher proportion of sensory auras and premotor semiology. Ictal pouting, vocalizations, and, in particular, laughter are strong indicators of epilepsy arising or spreading to this region. Although scalp EEG was traditionally thought to provide little information, the data provided in this review demonstrate that most patients will have abnormalities over the frontal or frontotemporal regions. Frontotemporal abnormalities at least interictally provide valuable information regarding lateralization. The etiology of epilepsy arising from the anterior cingulate region seems to be most frequently secondary to focal cortical dysplasia (FCD), followed by neoplasms and vascular lesions, particularly cavernomas, although one cannot rule out a publication bias. Findings of nuclear medicine imaging is seldomly reported but both positron emission tomography and ictal single-photon computed tomography can identify the generator or the network often showing abnormalities extending to the frontal regions. The few available magnetoencephalography (MEG) studies reveal mixed results, sometimes providing false lateralization of the focus. Anterior cingulate epilepsy is difficult to recognize, but the features summarized in this review should prompt suspicion in clinical practice.
Solitalea lacus sp. nov., isolated from pond sediment
Authors: Jung Ji Young , Lee Mi Hwa , Nam Young Ho , Kang Hye-Kyeong , Jeon Yu Jeong , Park Sanghwa , Han Ji-Hye , Kim Hyangmi 
Published: March 2023

A Gram-stain-negative, strictly aerobic, oxidase-positive, catalase-negative, motile by gliding, creamy white-pigmented bacterium, designated strain S2-8T, isolated from a sediment sample from a Wiyang pond in the Republic of Korea, was subjected to polyphasic taxonomic analysis. Growth was observed at 10–40 °C (optimum: 30 °C), pH 7–8 and 0–0.5% NaCl. Phylogenetic analyses based on 16S rRNA gene sequences revealed that strain S2-8T belonged to the family

Sphingobacteriaceae

in the phylum Bacteroidota and was closely related to

Solitalea longa

HR-AVT,

Solitalea canadensis

DSM 3403T and

Solitalea koreensis

R2A36-4T with 97.2, 96.7 and 93.7 % 16S rRNA gene sequence similarities, respectively. Average nucleotide identity and digital DNA–DNA hybridization values for these type strains were 72.0–75.2% and 21.2–21.9 %, respectively. The major respiratory quinone is menaquinone-7. The major fatty acids were iso-C15 : 0, iso-C17 : 0 3-OH and summed feature 3 (comprising C16 : 1
ω7c and/or C16 : 1
ω6c). The major polar lipids were phosphatidylethanolamine, two unidentified amino acids and four unidentified lipids. The G+C content of genomic DNA was 37.9 mol%. Based on polyphasic taxonomic analysis, it was observed that strain S2-8T is a novel species belonging to the genus

Solitalea

, for which the name Solitalea lacus sp. nov. is proposed. The type strain is S2-8T (= KACC 22266T= JCM 34533T).
A test of the gleaner-opportunist trade-off among photosynthetic traits in Cryptophyte algae
Authors: Swanson Jake A. , Greenwold Matthew J. , Richardson Tammi L. , Dudycha Jeffry L. 
Published: March 2023

AbstractAs photosynthetic producers, phytoplankton form the foundation of aquatic food webs. Understanding the relationships among photosynthetic traits in phytoplankton is essential to revealing how diversification of these traits allow phytoplankton to harvest energy from different light environments. We investigated whether the diversification of 15 species of cryptophytes, a phylum of phytoplankton with diverse light-capturing pigments, showed evidence of trade-offs among photosynthetic performance traits as predicted by the gleaner-opportunist resource exploitation framework. We constructed photosynthesis vs. irradiance (P-E) curves and rapid light curves (RLCs) to estimate parameters characterizing photosynthetic performance and electron transport rate. We inferred the evolutionary relationships among the 15 species with ultraconserved genomic elements and used a phylogenetically controlled approach to test for trade-offs. Contrary to our prediction, we observed a positive correlation between maximum photosynthetic rate,Pmax, andP-E α, an indicator of a species’ sensitivity to increases in light intensity when light is a scarce resource. This result could not be explained by electron transfer traits, which were uncorrelated with photosynthetic rate. Together, our results suggest that ecological diversification of light exploitation in cryptophytes has escaped the constraints of a gleaner-opportunist tradeoff. Photosynthetic trade-offs may be context or scale dependent, thereby only emerging when investigated in situations different from the one used here.
Microglia cannibalism and efferocytosis leads to shorter lifespans of developmental microglia
Authors: Gordon Hannah , Schafer Zachary , Smith Cody J. 
Published: March 2023

ABSTRACTThe overproduction of cells and subsequent production of debris is a universal principle of neurodevelopment. Here we show an additional feature of the developing nervous system that causes neural debris – promoted by the sacrificial nature of embryonic microglia that irreversibly become phagocytic after clearing other neural debris. Described as long-lived, microglia colonize the embryonic brain and persist into adulthood. Using transgenic zebrafish to investigate the microglia debris during brain construction, we identified that unlike other neural cell-types that die in developmental stages after they have expanded, necroptosis-dependent microglial debris is prevalent when microglia are expanding in the zebrafish brain. Time-lapse imaging of microglia demonstrates that this debris is cannibalized by other microglia. To investigate features that promote microglia death and cannibalism, we used time-lapse imaging and fate-mapping strategies to track the lifespan of individual developmental microglia. These approaches revealed that instead of embryonic microglia being long-lived cells that completely digest their phagocytic debris, once most developmental microglia in zebrafish become phagocytic they eventually die, including ones that are cannibalistic. These results establish a paradox -- which we tested by increasing neural debris and manipulating phagocytosis -- that once most microglia in the embryo become phagocytic, they die, create debris and then are cannibalized by other microglia, resulting in more phagocytic microglia that are destined to die.
Molecular basis of polyspecific drug binding and transport by OCT1 and OCT2
Authors: Suo Yang , Wright Nicholas J. , Guterres Hugo , Fedor Justin G. , Butay Kevin John , Borgnia Mario J. , Im Wonpil , Lee Seok-Yong 
Published: March 2023

AbstractA wide range of endogenous and xenobiotic organic ions require facilitated transport systems to cross the plasma membrane for their disposition1, 2. In mammals, organic cation transporter subtypes 1 and 2 (OCT1 and OCT2, also known as SLC22A1 and SLC22A2, respectively) are polyspecific transporters responsible for the uptake and clearance of structurally diverse cationic compounds in the liver and kidneys, respectively3, 4. Notably, it is well established that human OCT1 and OCT2 play central roles in the pharmacokinetics, pharmacodynamics, and drug-drug interactions (DDI) of many prescription medications, including metformin5, 6. Despite their importance, the basis of polyspecific cationic drug recognition and the alternating access mechanism for OCTs have remained a mystery. Here, we present four cryo-EM structures of apo, substrate-bound, and drug-bound OCT1 and OCT2 in outward-facing and outward-occluded states. Together with functional experiments,in silicodocking, and molecular dynamics simulations, these structures uncover general principles of organic cation recognition by OCTs and illuminate unexpected features of the OCT alternating access mechanism. Our findings set the stage for a comprehensive structure-based understanding of OCT-mediated DDI, which will prove critical in the preclinical evaluation of emerging therapeutics.
Auxin coreceptor IAA17/AXR3 controls cell elongation inArabidopsis thalianaroot by modulation of auxin and gibberellin perception
Authors: Kubalová Monika , Müller Karel , Dobrev Petre Ivanov , Rizza Annalisa , Jones Alexander M. , Fendrych Matyáš 
Published: March 2023

SummaryThe nuclear TIR1/AFB - Aux/IAA auxin pathway plays a crucial role in regulating plant growth and development. Specifically, the IAA17/AXR3 protein participates in root development, and the accumulation of its mutant variant, AXR3-1, which cannot bind auxin, leads to severe root growth phenotype and agravitropism. However, the mechanism by which AXR3 regulates cell elongation is not fully understood. Here we show that the inducible expression of AXR3-1 in theArabidopsis thalianaroot triggers excessive cell elongation that is followed by growth arrest of the root. We exploited this effect to reveal the underlying molecular mechanism of AXR3 action. We show that AXR3-1 acts exclusively in the nucleus where it interferes with the nuclear auxin transcriptional pathway, while the rapid cytoplasmic auxin root growth response is not affected. The analysis of the transcriptome of the induced AXR3-1 roots revealed changes in phytohormone perception and homeostasis. We show that the accumulation of AXR3-1 disturbs auxin homeostasis which leads to excessive auxin accumulation. At the same time, the reaction of the AXR3-1 roots to gibberellin is altered. These results show that the IAA17/AXR3 maintains an optimal cell elongation rate by controlling the auxin response, auxin homeostasis and the interplay with gibberellin signaling.
Engineering Particle-based Materials for Vasculogenesis
Authors: Claxton Natasha L. , Luse Melissa A. , Isakson Brant E. , Highley Christopher B. 
Published: March 2023

AbstractVascular networks are critical to the survival of cells within materials designed for regenerative medicine. Developing approaches to vascularize three-dimensional (3D)in vitromodels that recreate tissue physiology and 3D tissue constructs for regenerative medicine remain an important focus of tissue engineering. Granular hydrogels are emerging as a promising class of materials for the regeneration of damaged tissues and fabricating tissue constructs. While granular hydrogels have supported vasculature formed by angiogenesis and fabrication processes that establish channels, parameters for designing these materials to support formation of vasculature by vasculogenesis from cells contained within these materials are not fully understood and remain largely unexplored. In this study, vasculogenesis within 3D granular hydrogels formed from polyethylene glycol (PEG) microgels are studied for its potential to establish a microvascular network within this class of materials. Self-organization of endothelial cells into networks within hours is observed in the presence of fibroblasts, and the effects of cell adhesive ligands (RGD) and porosity are measured. Increasing porosity is observed to enhance vasculogenesis while the addition of RGD impairs microvessel network formation. This work establishes parameters that support robust microvasculature formation within granular hydrogels that might be broadly applicable to this class of materials, with implications for other morphogenetic processes in 3D systems.
Validation of marker-less pose estimation for 3D kinematics during upper limb reaching
Authors: Avni Inbar , Landau Lior , Shaked Galya , Rabani Anat Shkedy , Riemer Raziel , Arac Ahmet , Shmuelof Lior 
Published: March 2023

AbstractKinematic analysis of movement following brain damage is key for diagnosing motor impairments and for recovery assessment. Advances in computer vision offer novel marker-less tracking tools that could be implemented in the clinic due to their simple operation and affordability. An important question that arises is whether marker-less technologies are sufficiently accurate compared to well established marker-based technologies. This study aims to perform validation of kinematic assessment using two high-speed cameras and a 3D pose estimation model. Four participants performed reaching movements with the upper limb between fixed targets, in different velocities. Movement kinematics were simultaneously measured using the DeepBehavior model and marker-based optical motion capture (QTM), as a gold standard. The differences in corresponding joint angles, estimated from the two different methods throughout the analysis, are presented as a mean absolute error (MAE) of the elbow angle. Quantitatively, the MAE of all movements was relatively small across velocity and joints (~2°). In a condition where the movements were made towards the DeepBehavior cameras, and the view of the elbow was occluded in one of the cameras, the errors were higher. In conclusion, the results demonstrated that marker-less motion capture is a valid alternative to marker-based motion capture. Inaccuracies of the DeepBehavior system could be explained by occlusions of key-points and are not associated with failure of the pose estimation algorithm.
Standardizing and applying a mating-based whole-genome simulation approach reveals caution in using chromosome-level PCA and kinship estimates
Authors: Cui Zuxi , Schumacher Fredrick R. 
Published: March 2023

AbstractThis paper presents a new and efficient method for simulating pseudo-genotype data using the standardized protocol of SLiM, which offers a flexible alternative to traditional methods that rely on large genetic datasets. These datasets can be time-consuming to obtain, especially when institutional review board (IRB) review is involved, making simulation an attractive alternative. While HapGen v2 is the most popular genotype simulator, we found that SLiM has the potential for more customizable simulation to meet multiple needs.To validate our new method, we compared its performance among parallel simulations varying multiple parameters. Our results showed that SLiM is capable of simulating samples up to 333 times the input size, with a low rate of simulated samples that are 2nd or closer relatives (REV), making it a promising alternative to HapGen. We also applied our whole-genome simulation approach to sensitivity analyses of chromosome-level principal component analysis (PCA) and kinship estimation. Our findings revealed important insights into the sensitivity of PCA and kinship estimation, highlighting the unequal distribution of population structure across chromosomes and ancestries. Furthermore, our study provides experimental support for avoiding chromosome-level quality control statistics.Overall, our standardized protocol of SLiM offers a flexible new way to produce pseudo-genotype data, and our findings provide valuable insights that can advance research in the field. By demonstrating the potential of SLiM for more customizable simulations and highlighting the importance of considering the distribution of population structure across chromosomes and ancestries, our research has significant implications for the study of genetics and genomics.Author SummaryIn this publication, we introduce a novel approach to genotype simulation using a mating-based strategy in SLiM. Our approach mimics mitosis computationally and stands out as the only one available as of December 2022 that can maintain cross-chromosome associations during whole-genome level simulation, with no competitors in sight. Additionally, our approach is applicable to regional or chromosomal genotype simulation. When compared to the current gold-standard chromosome-level simulator, HapGen, our approach exhibits superior performance when generating large sample sizes (>13,000). We provide an application example that uses whole-genome simulation to underscore the importance of whole-genome quality control (QC) statistics, such as principal component analysis (PCA) and kinship estimates, compared to the chromosome-level ones. Results of the application indicate instability and bias in the chromosome-level QC statistics. Overall, our approach represents a valuable tool for genetics research that can assist in the evaluation and validation of genetic analyses, and people should avoid chromosome-level QC statistics.
S-allyl cysteine and Taurine attenuate diabetic nephropathy in rats via the inhibition of oxidative stress and recovering histopathological changes
Authors: Rais Nadeem , Ved Akash , Ahmad Rizwan , Parveen Kehkashan , Shadab Mohd. 
Published: March 2023

PurposeRenal failure is an end-stage consequence after persistent hyperglycemia during diabetic nephropathy (DN), and the etiology of DN has been linked to oxidative stress. The purpose of this research was to determine the beneficial synergistic effects of S-Allyl Cysteine (SAC) and Taurine (TAU) on oxidative damage in the kidneys of type 2 diabetic rats induced by hyperglycemia.Design/methodology/approachExperimental diabetes was developed by administering intraperitoneal single dose of streptozotocin (STZ; 65 mg/kg) with nicotinamide (NA; 230 mg/kg) in adult rats. Diabetic and control rats were treated with SAC (150 mg/kg), TAU (200 mg/kg) or SAC and TAU combination (75 + 100 mg/kg) for four weeks. The estimation of body weight, fasting blood glucose (FBG), oral glucose tolerance test (OGTT), oxidative stress markers along with kidney histopathology was done to investigate the antidiabetic potential of SAC/TAU in the NA/STZ diabetic group.FindingsThe following results were obtained for the therapeutic efficacy of SAC/TAU: decrease in blood glucose level, decreased level of thiobarbituric acid reactive substances (TBARS) and increased levels of GSH, glutathione-s-transferase (GST) and catalase (CAT). SAC/TAU significantly modulated diabetes-induced histological changes in the kidney of rats.Originality/valueSAC/TAU combination therapy modulated the oxidative stress markers in the kidney in diabetic rat model and also prevented oxidative damage as observed through histopathological findings.
Financial distress and tax avoidance: the moderating effect of the COVID-19 pandemic
Authors: Ariff Akmalia , Wan Ismail Wan Adibah , Kamarudin Khairul Anuar , Mohd Suffian Mohd Taufik 
Published: March 2023

PurposeThis paper examines whether financial distress is associated with tax avoidance and whether the COVID-19 pandemic moderates such association.Design/methodology/approachThe sample covers 38,958 firm-year observations from 32 countries during the period 2015–2020. Financial distress is measured using the ZSCORE by Altman (1968), while tax avoidance is based on the book-tax difference.FindingsFinancially distressed firms exhibit low tax avoidance pre- and during the pandemic periods. The authors find higher tax avoidance during the pandemic compared to the pre-pandemic period, but the pandemic enhances the negative relationship between financial distress and tax avoidance.Research limitations/implicationsThe study offers evidence on how financial distress drives firms to engage in more tax avoidance when firms globally encountered various levels of financial difficulty sparked by the economic challenges of the COVID-19 pandemic.Practical implicationsThe findings provide insights to policymakers on the need to monitor and incentivise financially distressed firms, especially during economic challenges due to pandemic.Originality/valueThis study adds to the limited, albeit important, evidence on the joint effect of the COVID-19 pandemic and financial distress on tax avoidance.
Study on the hydrodynamic performance of two typical groove liquid film seals considering cavitation
Authors: Li Xiao-Ying , Li Zhen-Tao , Hao Mu-Ming , Wang Qing-Yang , Wang Zeng-Li 
Published: March 2023

Purpose
The purpose of this paper is to investigate the hydrodynamic performance of liquid film seals with oblique grooves (OGs) and spiral grooves (SGs), considering cavitation, compare and analyze the differences between them.

Design/methodology/approach
Considering cavitation effect, the incompressible steady-state Reynolds equation was solved to obtain the sealing performance parameters of the liquid film seal with oblique groove and spiral groove.

Findings
The hydrodynamic performance of oblique groove seal (OGS) and spiral groove seal (SGS) shows a similar trend with the change of operating parameters. When the groove angle is less than 20°, the load-carrying capacity of SGS is better than that of OGS, while when the groove angle continues to increase, the hydrodynamic performance of OGS is slightly better than that of SGS, and more suitable for use under small differential pressure and high speed.

Originality/value
The hydrodynamic characteristics of liquid film seals with oblique grooves and spiral grooves considering cavitation effect were studied, which provides a theoretical reference for the application of oblique groove seal.
Value relevance of accounting information in an emerging market: the case of IFRS adoption by non-financial listed firms in Saudi Arabia
Authors: Chehade Sarah , Procházka David 
Published: March 2023

PurposeThe paper aims to provide empirical evidence of the impact of IFRS adoption on the value relevance of accounting information in the emerging market of Saudi Arabia.Design/methodology/approachThe sample consists of 98 non-financial listed firms operating in Saudi Arabia from 2014 to 2019, representing the years before and after IFRS adoption. The authors apply basic and extended price models to examine the value relevance of select accounting figures.FindingsThe authors findings provide evidence that accounting information is, generally, value relevant to the Saudi Arabian capital market. However, mixed results exist for particular accounting variables. Both earnings and cash flows are value-relevant in the period before and after IFRS adoption; equity is only relevant in the post-adoption period. Furthermore, IFRS adoption also increases the explanatory power of earnings. An increase in the value relevance of earnings and equity hurts the value relevance of cash flows. The effects are moderated by leverage and dividend policy.Originality/valueThe authors contribute to the ongoing discussion of the economic effects of IFRS adoption in emerging markets. The empirical findings show that initial concerns about IFRS adoption, as reflected by the negative coefficient within the regression analysis, are mitigated once the usefulness of the individual accounting variables published in financial statements is investigated.
Strategic planning: how it helped to resolve conflict in a new international joint venture
Authors: Wood Jr. Thomaz , Pasturino Marco , Caldas Miguel P. 
Published: March 2023

Purpose
The purpose of this study is to show how strategic planning can play multiple roles in the context of conflict between two controlling shareholders in a new joint venture.

Design/methodology/approach
This study conducted a five-year qualitative case study of a large financial services joint venture co-owned by a Latin American state bank and a European financial company.

Findings
The authors found that over time, budgeting and strategic planning had intertwining use to guide strategic decisions, but unexpectedly, strategic planning eventually developed three distinct roles beyond the merely functional, as it also contributed to complex symbolic and political functions.

Originality/value
This study provides guidance on considering different roles taken by strategic planning, as a utilitarian practice, as a symbolic narrative and as a conflict-mediating routine.