bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pricing cyber policies: a geospatial statistical approach
Authors: D'Amato Valeria , Ballestra Luca Vincenzo , Fersini Paola , Greco Fedele Pasquale , Forte Salvatore 
Published: February 2023

Abstract
Cyberspace consists in a complex mix of data, devices, and people. The virtual environment is based on different types of network layers, each of which has nodes that are locatable in space-time. Taking advantage of the growing volume of location-based information, mapping and keeping track of cyberattacks give an understanding of how improve the cyber resilience decision making, allowing to provide new tools for supporting the cybersecurity process. In brief, spatial approach enables to build a comprehensive model that more effectively assimilates all available data.
This paper presents a calculation method that, using the geospatial data of some companies, allows us to quantify the expected losses resulting from cyberattacks needed to price a policy to cover the cyber risk of data breaches. In particular, we examine the contribution of the spatial models in designing cyber risk policies for the insurance market.
In situ preparation of Bacterial cellulose/Hydroxyapatite scaffold in colloidal culture media containing Gum Tragacanth
Authors: Quan Vo Minh , Sukyai Prakit 
Published: February 2023

Abstract
The incorporation of Hydroxyapatite (HA) on bacterial cellulose has become an attempt in recent years to provide osteogenic abilities for the scaffold. In this study, gum tragacanth (GT) was added to the sugarcane juice media containing HA for Bacterial cellulose (BC) culturing to increase the attachment of the nanoparticles on cellulose fibers. The cellulose fibers experienced changes in fiber size and elemental components. The atomic % of Ca and P increased following the higher amount of HA added in BC culture media. The viability of pre-osteoblast cells MC3T3 was higher in scaffolds produced by the study compared to the net BC. The ALP activities of the cells on the scaffolds during 21 days of cultivation confirmed the differentiation support of the BGA scaffold. The method using colloidal media to attach nanoparticles on BC fibers is suggested to produce bioactive BC pellicle/fiber which opens other possibilities in BC applications.
Rupture Directivity of the 2019 ML 6.3 Xiulin (Taiwan) Earthquake Estimated by Near-Field Seismograms: Implications for Source Scaling During Faulting
Authors: Hwang Ruey-Der , Huang Yi-Ling , Chang Wen-Yen , Lin Cai-Yi , Lin Chiung-Yao 
Published: February 2023

Abstract
This study deconvolved regional seismograms to derive the azimuth-dependent source time functions for the 2019 Xiulin earthquake in Hualien, Taiwan. Then, rupture directivity analysis was used to estimate the fault parameters, and the results revealed a rupture length of 11.5 km, a source duration of 7.37 s, and a rupture velocity (Vr) of 1.56 km/s, approximately 0.4 times the value of the crustal S-wave velocity. Furthermore, the multiple-event analysis indicated two subruptures during the earthquake. Notably, the average rupture and the subrupture shared the same product of ΔσsVr3 (Δσs: static stress drop) and thus obeyed a specific source-scaling relationship. In short, the 2019 Xiulin earthquake had a relatively low Vr and a relatively high Δσs. We noted similarities between the 2018 Hualien and 2019 Xiulin earthquakes when comparing the fault parameters; rupture directivity analysis revealed that the two events occurred on a west-dipping plane with a similar strike. Therefore, the 2019 Xiulin earthquake likely constituted the remaining energy release of the 2018 Hualien earthquake.
Some rigidity theorems of closed curves in a CAT(k) space
Authors: Sama-Ae Areeyuth , Phon-on Aniruth , Makaje Nifatamah , Hazanee Areena , Riyapan Pakwan 
Published: February 2023

Abstract
In this paper, the characterizations of a closed polygonal curve in a CAT(k) space that bounds a geodesic surface which is isomet-ric to the region bounded by a polygon in the model space Sk with same perimeter are studied. The characterizations of a closed spherical curve in a CAT(k) space that bounds a geodesic surface which is isometric to the disk bounded by a circle in the model space Sk with same radii are also illustrated.
Mathematics Subject Classification (2010). 51K99.
P4HTM: A Novel Downstream Target of GATA3 in Breast Cancer
Authors: DiDonna Sarah C. , Nagornyuk Aerica , Adhikari Neeta , Takada Mamoru , Takaku Motoki 
Published: February 2023

Abstract
Breast cancer continues to be a major cause of death among women. The GATA3 gene is often overexpressed in breast cancer and is widely used to support a diagnosis. However, lower expression of GATA3 has been linked to poorer prognosis along with frequent gene mutations. Therefore, the role of GATA3 in breast cancer appears to be context specific. This study aims to identify a new downstream target of GATA3 to better understand its regulatory network. Clinical data analysis identified the prolyl 4-hydroxylase transmembrane protein (P4HTM) as one of the most highly co-expressed genes with GATA3. Immunohistochemical staining of breast tumors confirms co-expression between GATA3 and P4HTM at the protein level. Similar to GATA3, P4HTM expression levels are linked to patient prognosis, with lower levels indicating poorer survival. Genomics data found that GATA3 binds to the P4HTM locus, and that ectopic expression of GATA3 in basal breast cancer cells increases the P4HTM transcript level. These results collectively suggest that P4HTM is a novel downstream target of GATA3 in breast cancer and is involved in tumor progression.
Neighbor relation-aware graph convolutional network for recommendation
Authors: Li Yijia , Ren Zhilin 
Published: February 2023

Abstract
Existing recommender systems based on graph neural networks mainly aggregate the information of neighbors indiscriminately when updating the representation of the target node. In this way, most useful prior knowledge is not introduced in combination with the recommendation system itself to distinguish the relationship between users and items. To solve this problem, a Neighbor Relation-aware Graph Convolutional Network (NRGCN) is proposed, which combines three prior auxiliary information of rating, review text, and the timestamp to distinguish the expression differences of different neighbors in the neighborhood explicitly. Specifically, the user’s rating value is introduced as the basis for the closeness of the network, which is then modified by the sentiment rating of the review text. Besides, considering the changes in the user’s interest over time, the timestamp is used to encode the neighbor relationship at different times. Extensive experiments on three benchmark datasets show that our model outperforms various state-of-the-art models consistently, with a maximum increase of 12%.
How has COVID-19 changed health and social care professionals' attitudes to self-care? A mixed methods research study
Authors: Smith Pete Samuel , Alaa Aos , Sasco Eva Riboli , Bagkeris Emmanouil , El-Osta Austen 
Published: February 2023

AbstractBackground The COVID-19 pandemic fundamentally changed the way services are delivered. Self-care, including good hygiene practices and avoidance of risk was emphasised as the key measure to tackle the pandemic in the early stages. Objective To understand how self-reported professional attitudes, perceptions and practices of self-care have changed as a result of the COVID-19 pandemic. Design Cross-sectional online survey and semi-structured qualitative interview. Setting Health and social care. Participants 304 health and social care professionals. Methods A wide range of health and social care professionals took part in a 27-item anonymous online survey. Semi-structured qualitative interviews with nine health & social care professionals explored attitudes to and practices of self-care before and during the pandemic. Views were sought on the permanence and implications of changes. Data were analysed using routine statistics and thematic analysis to identify major themes. Results A total of 304 health and social care professionals responded to the survey fully. Nine participated in a semi-structured interview. There was agreement that the importance of self-care has increased markedly during the pandemic. The percentage of respondents who felt that self-care was 'extremely' important to their clients increased from 54.3% to 86.6% since the pandemic. Personal empowerment and capacity of service users to self-care increased significantly during the pandemic. Willingness of patients to engage (74%) and poor understanding of self-care (71%) were cited as the two main barriers to self-care. A close third was digital exclusion (71%), though 86% of respondents recommending online resources and 77% the use of smartphone apps. Survey respondents believed the changes to be permanent and positive. Interviewees reported a major, and positive move to self-care with the pandemic seen as an opportunity to be grasped, but professional education would have to be aligned to make the most of it. They raised concerns as to whether the shift to self-care was perceived by users as 'abandonment' rather than 'empowerment' and whether problems had been stored rather than dealt with through self-care and therefore whether the positive changes would continue after the pandemic. Conclusion Reporting their views before the pandemic, barely more than half of the professionals surveyed saw self-care as fundamentally important to the individuals they served. This changed to 86% as a result of the pandemic. Patient/client engagement with and understanding of self-care were reported as major barriers, as was digital exclusion, though, increased technological solutions were used by all respondents. Concerns were raised that the permanence of the changes depended upon continued encouragement and empowerment of individuals to self-care and on its inclusion in professional education as a substantive subject.
Single cell multi-omic dissection of response and resistance to chimeric antigen receptor T cells against BCMA in relapsed multiple myeloma
Authors: Grieb Nora , Weiss Ronald , Sia Jaren , Fischer Luise , Born Patrick , Boldt Andreas , Fricke Stephan , Franz Paul , Scolnick Jonathan , Venkatraman Lakshmi , Xu Stacy , Kloetzer Christina , Heyn Simone , Kubasch Anne , Baber Ronny , Wang Song , Bach Enrica , Hoffmann Sandra , Ussmann Jule , Schetschorke Birthe , Hell Saskia , Schwind Sebastian , Metzeler Klaus , Herling Marco , Jentzsch Madlen , Franke Georg , Sack Ulrich , Reiche Kristin , Koehl Ulrike , Platzbecker Uwe , Vucinic Vladan , Merz Maximilian 
Published: February 2023

Abstract
Markers predicting response and resistance to chimeric antigen receptor (CAR) T cells in relapsed/refractory multiple myeloma are currently missing. We subjected cells isolated from peripheral blood and bone marrow before and after the application of CAR T cells directed against B cell maturation antigen to single cell multi-omic analyses to identify markers associated with resistance and early relapse. Differences between responders and non-responders were already identified at time of leukapheresis. Non-responders showed an immunosuppressive microenvironment characterized by increased numbers of monocytes expressing the immune checkpoint molecule CD39 and suppressing CD8+ and NK cell function. The analyses of CAR T cells showed cytotoxic and exhausted phenotypes in hyperexpanded compared to low/intermediate expanded clones. We identified potential immunotherapeutic targets on CAR T cells, like PD1 and KLRB1, to improve their functionality and durability. Our work provides first evidence that an immunosuppressive microenvironment is associated with resistance to CAR T cell therapies.
Managerial Short-termism, Corporate Social Responsibility and Green Innovation: Empirical Evidence from China
Authors: Fan Min 
Published: February 2023

AbstractGreen innovation is key to promoting green development and all-round green transformation. Businesses are the backbone of green innovation. The Upper Echelons Theory tells us that the characteristics of managers can influence critical business decisions and therefore have an essential impact on green innovation strategies. Existing literature has discussed the impact of objective characteristics of managers on green innovation. However, there is little literature on the impact of managerial short-termism on green innovation in terms of its psychological characteristics. Based on the Time Orientation Theory, we believe that a manager's long-term vision is a booster for green innovation, while short-termism inhibits it. To test our idea, we perform a systematic analysis. Based on a theoretical analysis of the relationship between managerial short-termism and green innovation, we also demonstrate our hypothesis using quantitative analysis. Quantitative analysis finds that managerial short-termism does inhibit green innovation and remains true after robustness tests. We also find that the negative impact of managerial short-termism on green innovation is greater in samples with severe financing constraints and greater managerial power. And, in the mediation effect test, we demonstrate that managerial short-termism can influence green innovation by influencing CSR awareness. Finally, we performed an ecological consequence test and found that managerial short-termism ultimately leads to an increase in future carbon emissions in the city where the firm is located. The study enriched research on managerial short-termism and green innovation and provided influential references for subsequent research.
Charcot-Marie-Toothe Disease presenting with tremor; a rare presentation of hereditary polyneuropathy
Authors: Mohammed Salhadin , Tsehayneh Fikru , Kifelew Selam 
Published: February 2023

Abstract
Background: Charcot-Marie-Toothe (CMT) disease is a spectrum of inherited disorders caused by abnormalities in genes that are expressed in peripheral nerve myelin and/or axons. Typical features include both motor and sensory nerve manifestations with distal leg weakness, foot deformities (pes cavus, hammer toes), and sensory deficits. Postural tremor as a manifestation of CMT is seldom present, except in a variant of CMT1 (Roussy-Levy Syndrome), whose presentation includes postural tremor, gait ataxia, distal muscle atrophy, pes cavus, areflexia, and mild distal sensory loss.
Case Presentation: We present a 34-year-old right-handed male patient with tremor of the hands of 6 months duration. Associated with this, he has difficulty walking and weakness of the distal extremities bilaterally, initially and prominently involving the lower limbs. The patient says that his way of walking has been different as long as he remembers (slapping against the ground whenever he walks). The patient has no history of diabetes, hypertension, or any other chronic illness, and he has no family history of such illness. Physical examination revealed mild distal muscle weakness (4+/5 on upper limbs, while 3/5 on lower limbs), pes cavus deformity, absent ankle reflexes and mild vibratory sensory loss. We noted a postural tremor, that attenuates when the patient assumes anatomic position. The tremor is limited to the hands. NCS of Upper and lower Limbs showed moderate to severe motor axonal and demyelinating Polyneuropathy (Axonal > Demyelinating)- Suggestive of axonal predominant hereditary polyneuropathy. Subsequently done genetic testing revealed copy number changes (Heterozygous Deletion) on the MPZ and MFN2 Genes could be associated with CMT1B and CMT2A respectively; while the PMP22 gene showed ambiguous copy number changes (decrease) on exons 2 and 3. Tying the clinical, electrophysiologic and genetic findings, a consideration of CMT2A with postural tremor was made.
Conclusion: The present case describes a 34-year-old male patient with CMT2A presenting with neuropathic postural tremor, which is a rare presentation of a common hereditary polyneuropathy. This case highlights the fact that tremors can be associated with peripheral neuropathy syndromes, and a high index of suspicion is needed to rightly diagnose our patients.
Care of Confined Cattle
Authors: Blowey Roger W. 
Published: February 2023

The assessment of welfare and what is right for the cow is extremely difficult. It has been proposed (Webster 1984) that housing systems be assessed according to the degree that animals housed within them are free from 5 considerations:1. Freedom from hunger and malnutrition2. Free from thermal and physical discomfort3. Freedom from injury and disease4. Freedom from fear and stress5. Freedom to express normal behaviour.
It is likely that, of all of these, freedom from injury and disease are the most important and these are the 2 issues which will be considered in this paper. The major diseases associated with environmental stress in dairy cattle are lameness, mastitis and fertility. For housed stockyoung, enteric problems and pneumonia are the most important.
Coping With Catastrophic Ensiled Forage Losses
Authors: Seglar Bill 
Published: February 2023

Providing cattle the highest quality ensiled forages and grains possible for maximum milk and beef productivity is a goal for most crop growers and cattle feeders.
Pre-harvest weather related catastrophes such as flood, drought, wind, hail, and early frost can jeopardize this feeding goal, causing yield losses and reduction of nutrient quality of forages and grains. Harvest delays due to rainy seasons present another reason why quality crops may become less than ideal when fed out of the silo. These situations are out of the manager's control.
Post-harvest silage catastrophes within manager control include the ensiling of quality crops with less than ideal ensiling management practices. This includes situations where crops are ensiled with improper moisture, maturity, packing, sealing, and feedout management.
Aerobically unstable or Clostridial silages are the most common result when dealing with pre- and post-harvest catastrophes. Managing weather damaged crops prior to harvest and dealing with post-ensiling challenges requires managers to work with the principles of fermentation. 2,5
Practitioner's Perspective on Scours in Beef Calves
Authors: Adams James G. 
Published: February 2023

As in many other livestock diseases, diarrhea in young beef calves can be the symptom of the primary disease, or merely the result of a secondary or concurrent disease. The initial physical exam needs to look for respiratory disease, umbilical infection which may or may not have spread to the joints, and any evidence of birth defects or neurological conditions. Anything that interfers with nursing and the intake of adequate colostrum usually will result in diarrhea. It also is imperative to examine the cow for evidence of mastitis, uterine infection, or other diseases which may have impaired milk supply or produced more than the calf could easily handle (think Holstein-cross cows).
This may be easier said than done, since many times the first examination of the calf takes place in the pasture.
Veterinary Reproductive Programs
Authors: Ferguson James D. , Galligan David T. 
Published: February 2023

Reproduction influences farm gross income about 10%. Gross margin per cow is maximized when herd pregnancy rate (pregnancy efficiency) is above 30%. Pregnancy rate (PR) is calculated as the heat detection rate (HDR) times the conception rate (CR). Since CR is typically below 40% on most farms, HDR needs to be above 80% to achieve a PR above 30%.
Herd reproductive programs are most effective when they are used to control HDR. Furthermore, first insemination heat detection rates have a higher economic value than repeat heat detection rates. Synchronization programs using prostaglandin alone or in combination with GnRH have a high potential return for producers to improve reproductive efficiency. Synchronization programs have value on dairy farms as they control HDR, improve labor efficiency for insemination, and coordinate veterinary activities for pregnancy examination on a scheduled basis.
Risk Assessment and Strategic Management for the Reduced Incidence of Neonatal Calf Diarrhea
Authors: Pence Mel , Thompson John U. 
Published: February 2023

Risk factors associated with calf diarrhea were identified and management strategies were developed to reduce their impact on the incidence of disease. 541 cows were bred to calve. Between March 3 and May 15, 1998. A field investigation checklist was utilized to assess the risk factors in the herd for this year. Risk factors identified were: parity, different origin of the groups of cattle, weather, poor body condition score and intensity of calving. These cattle were 46% first calf heifers, and the remainder were mature cows. The first calf heifers were from 5 different sources, and the mature cows were from the Iowa State University (ISU) Rhodes farm. The groups had never been commingled.
Body condition scores of the cattle averaged below 5, and there was a high maintenance requirement because of muddy conditions and frequent wet hair coats due to continuing cold rains. The first 195 cows were due to calve in a total of 30 days, and 200 of the heifers were bred to calve in 26 days. Procedures were developed to allow a one-way flow of the cow/calf pairs through calving areas to reduce contact of the calves with possible large numbers of pathogens and separate first-parity heifers from the mature cows.
Amelioration of the Pulmonary Toxic Effects of 4-ipomeanol in Mice by Fermentation of Mold-damaged Sweet Potatoes
Authors: Thibodeau Michael S. , Rogers Glenn M. , Poore Matthew H. , Haglar Winston M. 
Published: February 2023

Stressed sweet potatoes infected with mold (Fusarium sp.) produce the furanoterpenoid 4-ipomeanol, which is pneumotoxic to cattle. Mechanical injury, chill injury, chemical injury, or infection with nematodes or fungi will stress sweet potatoes to produce toxic metabolites, which are further metabolized by Fusarium sp. The most abundant toxin produced is 4-ipomeanol. Pulmonary cytochrome P450 enzymes oxidize 4-ipomeanol to reactive species that cause pulmonary damage. Most of the pulmonary cytochrome P450 is contained in non-ciliated epithelial cells (Clara cells) that line bronchioles and bronchi. Within 1 day of ingestion, affected cattle develop interstitial pneumonia that causes an acute respiratory distress syndrome (ARDS). This can result in death from asphyxiation.
The risk of ARDS prevents the sweet potato from being used as cattle feed, which is unfortunate since there is an abundance of sweet potato waste in certain regions of the United States. The sweet potato is ranked 7th as a world crop. In 1995 approximately 1.3 billion pounds of sweet potatoes were produced in the United States. North Carolina alone produced 480 million pounds. Nearly 25% of the sweet potatoes harvested (approximately 1.8 million bushels) are culled, and are either dumped in a landfill or spread on crop land. Sweet potatoes have already been shown to have nutritional value equivalent to corn. Since pneumotoxicity excludes the sweet potato from use as a dietary source in cattle, we have begun investigating processing methods that may eliminate the furanoterpenoid toxins. To date our work suggests that simple processing methods may degrade the furanoterpenoids and eliminate pneumotoxicity.