bluuebunny/crossref_metadata_2025_split huggingface dataset:
The impact of diabetes on the relationship of coronary artery disease and outcome: a study using multimodality imaging
Authors: Mäenpää Matias , Kujala Iida , Harjulahti Esa , Stenström Iida , Nammas Wail , Knuuti Juhani , Saraste Antti , Maaniitty Teemu 
Published: May 2023

Abstract
Background
Patients with prediabetes or diabetes are at increased risk of developing cardiovascular disease and adverse outcomes. First-line coronary computed tomography angiography (CTA) followed by selective use of positron emission tomography (PET) myocardial perfusion imaging is a feasible strategy to diagnose and risk-stratify patients with suspected coronary artery disease (CAD). The aim of the present study was to study whether diabetes changes the relationship of CAD and long-term outcome.

Methods
We retrospectively identified consecutive symptomatic patients who underwent coronary CTA for suspected CAD. In patients with suspected obstructive CAD on CTA, myocardial ischemia was evaluated by 15O-water PET myocardial perfusion imaging. The relationship of the phenotype of CAD and long-term outcome in patients with no diabetes, prediabetes, or type 2 diabetes was investigated. A composite endpoint included all-cause mortality, myocardial infarction (MI), and unstable angina pectoris (UAP).

Results
A total of 1743 patients were included: 1214 (70%) non-diabetic, 259 (15%) prediabetic, and 270 (16%) type 2 diabetic patients. During 6.43 years of median follow-up, 164 adverse events occurred (106 deaths, 41 MIs, 17 UAPs). The prevalence of normal coronary arteries on CTA was highest in the non-diabetic patients (39%). The prevalence of hemodynamically significant CAD (abnormal perfusion) increased from 14% in non-diabetic patients to 20% in prediabetic and 27% in diabetic patients. The event rate was lowest in patients with normal coronary arteries and highest in patients with concomitant type 2 diabetes and hemodynamically significant CAD (annual event rate 0.2% vs. 4.7%). However, neither prediabetes nor diabetes were independent predictors of the composite adverse outcome after adjustment for the clinical risk factors and imaging findings.

Conclusions
Coronary CTA followed by selective downstream use of PET myocardial perfusion imaging predicts long-term outcome similarly in non-diabetic and diabetic patients.
Exploring views of members of the public and policymakers on the acceptability of population level dietary and active-travel policies: a qualitative study
Authors: Toumpakari Z , Valerino-Perea S. , Willis K. , Adams J. , White M. , Vasiljevic M. , Ternent L. , Brown J. , Kelly M. P. , Bonell C. , Cummins S. , Majeed A , Anderson S. , Robinson T. , Araujo-Soares V. , Watson J. , Soulsby I. , Green D. , Sniehotta F. F. , Jago R. 
Published: May 2023

Abstract
Background
There is limited evidence on what shapes the acceptability of population level dietary and active-travel policies in England. This information would be useful in the decision-making process about which policies should be implemented and how to increase their effectiveness and sustainability. To fill this gap, we explored public and policymakers’ views about factors that influence public acceptability of dietary and active-travel policies and how to increase public acceptability for these policies.

Methods
We conducted online, semi-structured interviews with 20 members of the public and 20 policymakers in England. A purposive sampling frame was used to recruit members of the public via a recruitment agency, based on age, sex, socioeconomic status and ethnicity. Policymakers were recruited from existing contacts within our research collaborations and via snowball sampling. We explored different dietary and active-travel policies that varied in their scope and focus. Interviews were transcribed verbatim and analysed using thematic reflexive analysis with both inductive and deductive coding.

Results
We identified four themes that informed public acceptability of dietary and active-travel policies: (1) perceived policy effectiveness, i.e., policies that included believable mechanisms of action, addressed valued co-benefits and barriers to engage in the behaviour; (2) perceived policy fairness, i.e., policies that provided everyone with an opportunity to benefit (mentioned only by the public), equally considered the needs of various population subgroups and rewarded ‘healthy’ behaviours rather than only penalising ‘unhealthy’ behaviours; (3) communication of policies, i.e., policies that were visible and had consistent and positive messages from the media (mentioned only by policymakers) and (4) how to improve policy support, with the main suggestion being an integrated strategy addressing multiple aspects of these behaviours, inclusive policies that consider everyone’s needs and use of appropriate channels and messages in policy communication.

Conclusions
Our findings highlight that members’ of the public and policymakers’ support for dietary and active-travel policies can be shaped by the perceived effectiveness, fairness and communication of policies and provide suggestions on how to improve policy support. This information can inform the design of acceptable policies but can also be used to help communicate existing and future policies to maximise their adoption and sustainability.
Metastasis from follicular lymphoma to an ovarian mature teratoma: a case report of tumor-to-tumor metastasis
Authors: Sato Yusuke , Yano Mitsutake , Eto Satoshi , Takano Kuniko , Nasu Kaei 
Published: May 2023

Abstract
Background
Tumor-to-tumor metastasis (TTM) is a rare but well-established phenomenon where histologically distinct tumors metastasize within each other. Here we report the first “known” case of follicular lymphoma that metastasized and extended to a mature ovarian teratoma.

Case
presentation
A
59-year-old Japanese postmenopausal woman visited our hospital for a detailed
examination of an ovarian tumor. Clinical imaging suggested it to be either
teratoma-associated ovarian cancer with multiple lymph node metastases, or
tumor-to-tumor metastasis from malignant lymphoma to ovarian teratoma. A
bilateral adnexectomy and retroperitoneal lymph node biopsy were performed.
Lined with squamous epithelium, the cyst constituted a mature ovarian teratoma,
and the solid part showed diffuse proliferation of abnormal lymphoid cells.
Immunohistochemically, the abnormal
lymphoid cells were negative for CD5, MUM1, and CyclinD1, and positive
for CD10, CD20, CD21, BCL2, and BCL6. Genetic analysis using G-banding and
fluorescence in situ hybridization identified a translocation of t(14;18)
(q32;q21), and we diagnosed tumor-to-tumor metastasis from nodal follicular lymphoma
to mature ovarian teratoma. Twelve months after surgery, the patient showed no
progression without adjuvant therapy.

Conclusions
The present case suggests that
molecular approaches are useful in the diagnosis of TTM in mature ovarian
teratomas when morphologic and immunohistochemical findings alone are insufficient
for diagnoses.
Impact of macrolide treatment on long-term mortality in patients admitted to the ICU due to CAP: a targeted maximum likelihood estimation and survival analysis
Authors: Reyes Luis Felipe , Garcia Esteban , Ibáñez-Prada Elsa D. , Serrano-Mayorga Cristian C. , Fuentes Yuli V. , Rodríguez Alejandro , Moreno Gerard , Bastidas Alirio , Gómez Josep , Gonzalez Angélica , Frei Christopher R. , Celi Leo Anthony , Martin-Loeches Ignacio , Waterer Grant 
Published: May 2023

Abstract
Introduction
Patients with community-acquired pneumonia (CAP) admitted to the intensive care unit (ICU) have high mortality rates during the acute infection and up to ten years thereafter. Recommendations from international CAP guidelines include macrolide-based treatment. However, there is no data on the long-term outcomes of this recommendation. Therefore, we aimed to determine the impact of macrolide-based therapy on long-term mortality in this population.

Methods
Registered patients in the MIMIC-IV database 16 years or older and admitted to the ICU due to CAP were included. Multivariate analysis, targeted maximum likelihood estimation (TMLE) to simulate a randomised controlled trial, and survival analyses were conducted to test the effect of macrolide-based treatment on mortality six-month (6 m) and twelve-month (12 m) after hospital admission. A sensitivity analysis was performed excluding patients with Pseudomonas aeruginosa or MRSA pneumonia to control for Healthcare-Associated Pneumonia (HCAP).

Results
3775 patients were included, and 1154 were treated with a macrolide-based treatment. The non-macrolide-based group had worse long-term clinical outcomes, represented by 6 m [31.5 (363/1154) vs 39.5 (1035/2621), p < 0.001] and 12 m mortality [39.0 (450/1154) vs 45.7 (1198/2621), p < 0.001]. The main risk factors associated with long-term mortality were Charlson comorbidity index, SAPS II, septic shock, and respiratory failure. Macrolide-based treatment reduced the risk of dying at 6 m [HR (95% CI) 0.69 (0.60, 0.78), p < 0.001] and 12 m [0.72 (0.64, 0.81), p < 0.001]. After TMLE, the protective effect continued with an additive effect estimate of − 0.069.

Conclusion
Macrolide-based treatment reduced the hazard risk of long-term mortality by almost one-third. This effect remains after simulating an RCT with TMLE and the sensitivity analysis for the HCAP classification.
STING mediates experimental osteoarthritis and mechanical allodynia in mouse
Authors: Shin Youngnim , Cho Deborah , Kim Seul Ki , Chun Jang-Soo 
Published: May 2023

Abstract
Background
This study was performed to develop therapeutic targets of osteoarthritis (OA) that can be targeted to alleviate OA development (i.e., cartilage destruction) and relieve the OA-associated joint pain.

Methods
The candidate molecule, STING (stimulator of interferon genes, encoded by Sting1), was identified by microarray analysis of OA-like mouse chondrocytes. Experimental OA in mice was induced by destabilization of the medial meniscus (DMM). STING functions in OA and hindpaw mechanical allodynia were evaluated by gain-of-function (intra-articular injection of a STING agonist) and loss-of-function (Sting1−/− mice) approaches.

Results
DNA damage was observed in OA-like chondrocytes. Cytosolic DNA sensors, STING and its upstream molecule, cGAS (cyclic GMP-AMP synthase), were upregulated in OA chondrocytes and cartilage of mouse and human. Genetic ablation of STING in mice (Sting1−/−) alleviated OA manifestations (cartilage destruction and subchondral bone sclerosis) and hindpaw mechanical allodynia. In contrast, stimulation of STING signaling in joint tissues by intra-articular injection of cGAMP exacerbated OA manifestations and mechanical sensitization. Mechanistic studies on the regulation of hindpaw mechanical allodynia revealed that STING regulates the expression of peripheral sensitization molecules in the synovium and meniscus of mouse knee joints.

Conclusion
Our results indicated that STING, which senses damaged cytosolic DNA and accordingly activates the innate immune response, regulates OA pathogenesis and hindpaw mechanical allodynia. Therefore, inhibition of STING could be a therapeutic approach to inhibit OA cartilage destruction and relieve the associated mechanical sensitization in model mice.
A relation-theoretic set-valued version of Prešić-Ćirić theorem and applications
Authors: Shukla Satish , Rai Shweta , Shukla Rahul 
Published: May 2023

AbstractIn this paper, we establish a relation-theoretic set-valued version of the fixed point result of Ćirić and Prešić (Acta Math. Univ. Comen. LXXVI(2):143–147, 2007) on metric spaces endowed with an arbitrary binary relation. The results of this paper, generalize and unify the fixed point results of Ćirić and Prešić (Acta Math. Univ. Comen. LXXVI(2):143–147, 2007), Shukla and López (Quaest. Math. 45(3):1–16, 2019), and Shukla and Radenović (An. Ştiinţ. Univ. ‘Al.I. Cuza’ Iaşi, Mat. 63(2):339–350, 2017) in product spaces. Some examples are provided that justify and establish the importance of our results. As applications of our main result, we have established the existence of solutions to differential inclusion problems and the weak asymptotical stability and a global attractivity of the equilibrium point of a difference inclusion problem. The use of arbitrary binary relations in our results permits us to apply the results to the differential inclusion problems and difference inclusion problems with weaker assumptions than those used in the papers mentioned above.
Jointly improving energy efficiency and smoothing power oscillations of integrated offshore wind and photovoltaic power: a deep reinforcement learning approach
Authors: Yin Xiuxing , Lei Meizhen 
Published: May 2023

AbstractThis paper proposes a novel deep reinforcement learning (DRL) control strategy for an integrated offshore wind and photovoltaic (PV) power system for improving power generation efficiency while simultaneously damping oscillations. A variable-speed offshore wind turbine (OWT) with electrical torque control is used in the integrated offshore power system whose dynamic models are detailed. By considering the control system as a partially-observable Markov decision process, an actor-critic architecture model-free DRL algorithm, namely, deep deterministic policy gradient, is adopted and implemented to explore and learn the optimal multi-objective control policy. The potential and effectiveness of the integrated power system are evaluated. The results imply that an OWT can respond quickly to sudden changes of the inflow wind conditions to maximize total power generation. Significant oscillations in the overall power output can also be well suppressed by regulating the generator torque, which further indicates that complementary operation of offshore wind and PV power can be achieved.
Gait analysis of patients with Parkinson-plus syndromes: a research article
Authors: Tandon Ruchika , Yadav Ganesh , Singh Balendra Pratap , Gupta Anil Kumar 
Published: May 2023

Abstract
Background
Aim of the observational study was to assess which of the gait and balance parameters are most affected in Parkinson-plus syndromes patients with falling tendencies as compared to healthy individuals.

Methods
Authors studied levodopa-responsive patients of multiple system atrophy (MSA) and progressive supranuclear palsy (PSP) who had falling tendencies early in the disease and healthy controls and evaluated the spatiotemporal gait parameters using BTS G WALK and balance parameters by Limits of Stability test on BIODEX Balance system SD in the Gait and Motion Analysis Lab.

Results
In comparison to controls, Parkinson-plus syndromes patients had significantly different gait and balance parameters, apart from stride time and stance time, pelvic obliquity and pelvic tilt, cadence, hip abduction–adduction and hip rotation, foot progression, gait profile score, gait variable hip abduction–adduction, rotation, gait variable flexion–extension and gait deviation index (p-values < 0.05). Also, in comparison to MSA patients, PSP patients had significantly greater values of all static parameters except for swing time, step width, pelvic tilt and rotation, hip rotation and ankle dorsiflexion-plantarflexion, gait profile score of right limbs and all gait variable parameters except for pelvic tilt and hip flexion–extension, foot progression and gait deviation index of right limb. However, balance parameters were similar in MSA and PSP. Duration of disease and duration since falls may not significantly affect gait and balance parameters in Parkinson-plus syndromes patients.

Conclusions
Hence, gait differentiates between Parkinson-plus patients and healthy controls and between MSA and PSP patients with falling tendencies and gait and balance parameters may also help in planning rehabilitative strategies.
Core Books and Post-Pandemic Pedagogy
Authors: Garcia Ruth G. , Rosen Jody R. 
Published: May 2023

Abstract
Responses to the COVID-19 pandemic have increased feelings of isolation and lack of support among faculty. Grounded in collaborative curriculum and professional development, the Core Books at CUNY project offers faculty the opportunity to work together to incorporate texts from Columbia University's core curriculum into first-year writing (FYW) courses. The project invites faculty to collaboratively develop, implement, and reflect on the shared curriculum. As an Open Educational Resource (OER), the resulting curriculum was well positioned to become part of CUNY's Model Course Initiative that makes consistent curriculum easily shareable on the college's OpenLab, an open platform for teaching, learning, and collaboration. This curriculum provides the agility necessary for post-pandemic teaching as it builds a sustained community among participating contingent and full-time faculty and across community-building initiatives. It provides support on multiple levels, is flexible and adaptable for new situations—pandemic or otherwise—and ameliorates the isolation of teaching. Community through shared curriculum is therefore a way forward and a model for English departments in the post-pandemic future.
“An Excellent Adventure . . . ”
Authors: Glasgow Sara M. 
Published: May 2023

Abstract
Where do our most cherished teaching principles derive? How do we deploy them in ways that motivate students and nurture their critical engagement with the wider world? Drawing on insights gleaned from the film Bill and Ted's Excellent Adventure, this reflection explores how the development of two key strategies—engaging students through blended academic and pop-culture approaches and guiding their recognition and critical response to discursive power structures—transformed the author's pedagogical approach into one that is more student-centric and practically focused. Developed in the context of political science courses, but applicable especially to English and its instruction, these strategies decenter the instructor to promote more authentic engagement between students and the content they encounter, as well as with each other and the instructor. The strategies themselves, however, derive from a recognition that even the most light-hearted fare (such as Bill and Ted) may offer thoughtful insight into the craft of teaching: first, by recognizing that joy, passion, and creativity matter when structuring engaging learning experiences; and second, by clarifying how our attunement and response to subtle exercises of power—in the case of the film, pedagogical norms around acceptable academic projects—are instrumental in navigating a complex world.
Health professionals KAP study on rabies exposure assessment and NTV administration in Ethiopia
Authors: Aga Abebe M. , Mulugeta Demise , Tesera Yeweynshet , Hurisa Birhanu , Lemma Hailu , Bizuneh Ayele , Mohammed Jemal , Beyene Mekoro , Mulugeta Yimer , Ashenafi Bayeh , Woldekidan Samuel , Nigussie Dereje 
Published: May 2023

Background: Globally, it’s estimated 60,000 human deaths occur due to rabies with 95% of cases occurring in Africa and Asia. Annually, thousands of people are infected with rabies in Ethiopia and more than 2700 people die. In Ethiopia, the neural-based vaccine has been used since the 1950’s. Due to the old method of production, low immunogenicity and vaccine associated adverse events, WHO discourage the use of this vaccine and recommend replacing it with a safe and effective modern cell culture vaccine. There was no specific guidelines and training for this vaccine and health professional mismanage the nerve tissue vaccine (NTV) with cell culture vaccine resulting in vaccination failure. This study identifies professional knowledge, attitude and practice (KAP), vaccine related adverse events and the burden of rabies cases in humans. Methods: Data were collected from health professionals in selected health facilities using structured questionnaire to identify the level of KAP. Results: The study identified overall gaps in the professionals KAP as below standard which is not more than 25%. The majority of the respondents (97%) reported vaccine associated local adverse events followed by 20% systemic complications during vaccination. Only 2.4% of the respondents reported post-vaccine complications. Rabies cases in humans at those covered health facilities were reported to be 32 during the one-year study period with an average of two cases at each facility. Conclusions: Gaps identified in the professional KAP result indicate the need to provide specific training based on standard guidelines. Generally, the study indicates the need to strengthen rabies prevention and control efforts through inter-sectoral collaboration, and facilitating the establishment of facility-based rabies palliative care centers. In addition, it is recommended to work on technology transfer to replace old method of NTV production with safe and effective modern cell culture based anti-rabies vaccine production for effective rabies PEP.
Evaluation of a termination of pregnancy education programme in the Republic of Ireland: part 1
Authors: Fletcher Antoinette , Cowman Triona , Cazzini Hazel , Fleming Judith , Healy Niamh 
Published: May 2023

Background/Aims The extension of termination of pregnancy services in the Republic of Ireland represents a significant change to practice. Education is required so that nurses and midwives can fulfil their expanded role. The aim of this study was to provide an evaluation of a national termination of pregnancy education programme for midwives and nurses in the Republic of Ireland. Methods Kirkpatrick's framework for evaluation was used to create an online questionnaire that captured nurses' and midwives' reactions to a training experience at a termination of pregnancy education programme and their self-assessed knowledge before and after training. Results Participation in the training programme increased the participants' knowledge and confidence in caring for women having a termination. Participants reported that the training was relevant, met their expectations and new knowledge would be used. Recommendations for programme enhancement were also received. Conclusions Participants were satisfied with the education that they received. The positive impact that a short educational intervention had on participants' knowledge and confidence in providing care for women choosing termination of pregnancy was demonstrated.