bluuebunny/crossref_metadata_2025_split huggingface dataset:
Modeling skewness in portfolio choice
Authors: Le Trung H. , Kourtis Apostolos , Markellos Raphael 
Published: March 2023

AbstractWe seek the best skewness models for portfolio choice decisions. To this end, we compare the predictive ability and portfolio performance of several prominent skewness models in a sample of 10 international equity market indices. Overall, models that employ information from the option markets outperform models that only rely on stock returns. We propose an option‐based skewness estimator that accounts for the skewness risk premium. This estimator offers the most informative forecasts of future skewness, the lowest prediction errors, and the best portfolio performance in most of our tests.
Between purgatory and paradise: Exploring the role of social media in the lives of public intellectuals
Authors: Ream Todd C. 
Published: March 2023

AbstractIn this transitory age for public intellectuals, faculty must wisely negotiate the differences between public and private communication. The work of public intellectuals in colleges and universities raises questions about the methods used to assess the impact this work and the modes of communication with the lay public. This chapter discusses the pervasive nature of social media in the lives of public intellectuals and to what end the platforms they utilize can be leveraged in positive ways.
Inhibition of ox‐LDL‐induced endothelial cell injury by LINC02381 knockdown through the microRNA‐491‐5p/transcription factor 7 axis
Authors: Zhu Xizheng , Xu Hui , Chen Beijia 
Published: March 2023

AbstractAtherosclerosis (AS) is a complex multifactorial and chronic inflammatory vascular disease that contributes to the development of cardiovascular diseases. Abnormal cellular proliferation in human umbilical vein endothelial cells (HUVECs) is a crucial element in AS development. In this study, we investigated the potential role of the long noncoding RNA LINC02381/microRNA (miR)‐491‐5p/transcription factor 7 (TCF7) axis in regulating HUVEC injury in 30 participants suffering from AS and 30 healthy control participants. We established an in vitro model of AS in HUVECs using oxidized low‐density lipoprotein (ox‐LDL), and measured cellular mRNA and protein levels of LINC02381, miR‐491‐5p, and TCF7 in serum samples using reverse transcription‐quantitative polymerase chain reaction and Western blotting assays. We evaluated cell viability, apoptosis, and inflammation using Cell Counting Kit‐8, flow cytometry, and enzyme‐linked immunosorbent assays, respectively. Moreover, we analyzed apoptosis‐related protein expression using western blotting analysis and determined the association between miR‐491‐5p and LINC02381 or TCF7 using dual‐luciferase reporter assay, RNA pull‐down, and rescue experiments. We observed that LINC02381 was elevated, while miR‐491‐5p was downregulated in serum samples from participants with AS and in ox‐LDL‐treated HUVECs. LINC02381 knockdown was protective against HUVEC injury via miR‐491‐5p inhibition, which is its downstream target. Rescue experiments further demonstrated that miR‐491‐5p alleviated HUVEC injury by modulating TCF7. Thus, LINC02381 knockdown ameliorated HUVEC injury by regulating the miR‐491‐5p/TCF7 axis, which provides new insights into AS treatment strategies.
The potential value of cuprotosis in myocardial immune infiltration that occurs in pediatric congenital heart disease in response to surgery with cardiopulmonary bypass
Authors: Puwei Song , Siyu Ma , ZhuoGa DeQin , Kede Wu , Zhaocong Yang , Patel Nishant , Xiaoxu Liu , Xuming Mo 
Published: March 2023

AbstractBackgroundCardiopulmonary bypass may cause malfunction in the myocardium. Cuproptosis is a novel cell death aggregating mitochondrial proteins. However, the research on cardiopulmonary bypass‐caused heart tissue injury in immune infiltration and cuproptosis is limited.MethodImmune infiltration, enrichment analysis, protein−protein interaction network, and medication prediction are applied to reanalysis differentially expressed genes and cuproptosis‐related genes in gene expression omnibus data set GSE132176.ResultsSeven cuproptosis related genes (PDHA1, LIPT1, LIAS, DLST, DLD, DLAT, and DBT) and dendritic cells and Th1 cells are involved in heart tissue injury in response to surgery with cardiopulmonary bypass.ConclusionsImmune infiltration and cuproptosis are potential mechanisms by which cardiopulmonary bypass surgery may cause damage to heart tissue, which may be a new therapeutic target.
TBK1 promotes thyroid cancer progress by activating the PI3K/Akt/mTOR signaling pathway
Authors: Jiang Qiuli , Guan Yingying , Zheng Jingmei , Lu Huadong 
Published: March 2023

AbstractIntroductionThyroid cancer has received increasing attention; however, its detailed pathogenesis and pathological processes remain unclear. We investigated the role of TANK‐binding kinase 1 (TBK1) in the progression of thyroid cancer.MethodsThe expression of TBK1 in thyroid cancer and normal control tissues was analyzed using real‐time quantitative polymerase chain reaction. The function of TBK1 on thyroid cancer cells was detected using MTT, colony formation, wound healing, and Transwell assays. The xenograft assay was carried out to check on the role of TBK1 in thyroid cancer.ResultsTBK1 was highly expressed in thyroid tumors. High expression of TBK1 raised viability, proliferation, migration, and invasion of thyroid cancer cells. Gene set enrichment analysis revealed that TBK1 activated the phosphatidylinositol‐3‐kinase/protein kinase B/mammalian target of rapamycin pathway. In addition, Myc‐associated zinc finger protein (MAZ) was overexpressed in thyroid cancer and transcriptionally activated BK1. MAZ silence reversed the effects of TBK1 overexpression on thyroid cancer progression. Cotransfection with MAZ small‐interfering RNA(siRNA) and TBK1 siRNA did not strengthen the inhibitory effect of TBK1 silencing on the thyroid cancer cells. The xenograft tumor assay showed that TBK1 short hairpinRNA inhibited tumor growth.ConclusionMAZ silencing inhibited tumor progress of thyroid cancer cells, whereas this inhibitory effect was reversed by TBK1 overexpression.
Association of ITM2A rs1751094 polymorphism on X chromosome in Korean pediatric patients with autoimmune thyroid disease
Authors: Cho Won K. , Baek In‐Cheol , Kim Sung E. , Kim Mirae , Kim Tai‐Gyu , Suh Byung‐Kyu 
Published: March 2023

AbstractBackgroundAutoimmune thyroid disease (AITD) manifests with a female predominance, and much attention has been directed towards the integral membrane protein 2 A (ITM2A) gene located on the X chromosome.MethodsIn a study of 166 pediatric patients with autoimmune thyroid disease (AITD), the ITM2A rs1751094 single‐nucleotide polymorphism (SNP) was genotyped. The sample comprised 143 females and 23 males, with 67 patients diagnosed with Hashimoto chronic thyroiditis (HD) and 99 with Graves' disease (GD). In the 99 GD patients, 49 (49.5%) exhibited thyroid‐associated ophthalmopathy (TAO). Among the 85 GD patients, 70.6% (60/85) were considered intractable GD. The results were compared to those from 198 healthy Korean individuals, including 97 females and 101 males.ResultsThe frequency of the rs1751094 C allele and CC/AC genotype were higher in AITD, GD and HD patients compared to controls, while the frequency of the A allele and AA genotype were lower. The results were more pronounced in female AITD and GD patients compared to male patients. The association was also found in intractable GD and TAO patients. Target SNP fits Hardy–Weinberg equilibrium.ConclusionsThese findings indicate that the ITM2A gene polymorphism on the X chromosome may contribute to the immunological basis of female‐predominant AITD in Korean children.
Female reproductive and hormonal factors and lung cancer mortality among never‐smokers: A prospective cohort study of 287 408 Chinese women
Authors: Cheng Elvin S. , Velentzis Louiza S. , Weber Marianne , Steinberg Julia , Canfell Karen , Yu Xue Qin 
Published: March 2023

AbstractThere is growing, but inconsistent evidence suggesting oestrogen may play a key role in lung cancer development, especially among never‐smoking women for whom lung cancer risk factors remain largely elusive. Using the China Kadoorie Biobank, a large‐scale prospective cohort with 302 510 women aged 30 to 79 years recruited from 10 regions in China during 2004 to 2008, we assessed the risk of lung cancer death among self‐reported never‐smoking women who were cancer‐free at baseline, in relation to age at menarche, age at menopause, time since menopause, prior use of oral contraceptives (OCP), number of livebirths, breastfeeding and age at first livebirth. Women were followed up to December 31, 2016 with linkage to mortality data. Hazard ratios (HR) and 95% confidence intervals (CI) were estimated using Cox regression, adjusting for key confounders including several socio‐demographic, environmental and lifestyle factors. Among 287 408 never‐smoking women, 814 died from lung cancer with a median follow‐up of 10.3 years. Women who had used OCP within 15 years prior to baseline had a significantly higher hazard of lung cancer death compared with never‐users: HR = 1.85 (95% CI: 1.14‐3.00) and risk increased by 6% with each additional year of use: HR = 1.06 (1.01‐1.10). Among parous women, the hazard of lung cancer death increased by 13% with each single livebirth: HR = 1.13 (1.05‐1.23); and among post‐menopausal women, the risk increased by 2% with each year since menopause: HR = 1.02 (1.01‐1.04). These results suggest that reproductive factors which were proxies for lower endogenous oestrogen level, for example, longer duration of OCP use, could play a role in lung cancer development.
Long‐term outcomes of sirolimus treatment for kaposiform hemangioendothelioma: Continuing successes and ongoing challenges
Authors: Zhou Jiangyuan , Li Yanan , Qiu Tong , Gong Xue , Yang Kaiying , Zhang Xuepeng , Zhang Zixin , Lan Yuru , Hu Fan , Peng Qiang , Zhang Yongbo , Kong Feiteng , Chen Siyuan , Ji Yi 
Published: March 2023

AbstractTreatment with sirolimus, an inhibitor of the mammalian target of rapamycin pathway, has improved the prognosis of patients with kaposiform hemangioendothelioma (KHE). However, the efficacy, durability and tolerability of long‐term sirolimus treatment in patients with KHE have not been well elucidated. We performed efficacy and safety assessments based on more than 4.5 years of follow‐up in patients receiving sirolimus therapy for KHE. One hundred sixty‐seven patients were analyzed, including 102 (61.1%) patients with the Kasabach‐Merritt phenomenon (KMP). Follow‐up was conducted after a median of 56.0 months. A total of 154 (92.2%) patients had a durable response to sirolimus treatment. No difference in durable response was found between patients without KMP and patients with KMP (95.4% vs 90.2%; difference, 5.2%; 95% confidence interval [CI], −4.0% to 13.1%). Rebound growth occurred in 17.3% of patients upon sirolimus discontinuation. Early treatment discontinuation (odds ratio [OR]: 3.103; 95% CI: 1.529‐6.299; P = .002) and mixed lesion type (OR: 2.271; 95% CI: 0.901‐5.727; P = .047) were associated with tumor rebound growth. No KHE‐related deaths occurred in this cohort. At the last follow‐up, approximately 17.4% of patients had active disease and/or changes in body structures to a variable extent. Serious adverse events occurred most commonly during the first year of sirolimus therapy. Follow‐up of almost 4.5 years demonstrated that the efficacy of sirolimus persisted over time and that long‐term treatment with sirolimus was not associated with unacceptable cumulative toxicities. However, nonresponse, tumor relapse and long‐term sequelae remained challenges despite intensified and prolonged sirolimus therapy.
Obesity increases the odds of multiple pregnancies: A nationwide register‐based cohort study in Finland
Authors: Vaajala Matias , Liukkonen Rasmus , Kuitunen Ilari , Ponkilainen Ville , Kekki Maiju , Mattila Ville M. 
Published: March 2023

AbstractObjectiveTo investigate the effects of increased pre‐pregnancy body mass index (BMI, calculated as weight in kilograms divided by the square of height in meters) on the risk of having spontaneous multiple pregnancies using a nationwide register‐based study sample.MethodsData from the National Medical Birth Register (MBR) (2004–2018) were used to evaluate the effects of a higher pre‐pregnancy BMI on the risk of multiple pregnancies. Lower and higher pre‐pregnancy BMI classes, using the WHO classification, were compared with a normal weight class. A logistic regression model was used to assess the primary outcomes. Adjusted odds ratios (aOR) with 95% confidence intervals (CI) between the groups were compared. The model was adjusted by maternal age, maternal height, and maternal smoking status.ResultsThe odds of multiple pregnancies were higher among women in the overweight group (aOR 1.07, 95% CI 1.02–1.12), obesity class I group (aOR 1.11, 95% CI 1.04–1.18), and obesity class II group (aOR 1.15, 95% CI 1.03–1.28) compared with women in the non‐overweight BMI class. Women in the underweight group had lower odds for multiple pregnancies (aOR 0.82, 95% CI 0.73–0.93).ConclusionThe odds of multiple pregnancies slightly increase with pre‐pregnancy obesity, and this should be acknowledged as a minor risk factor for multiple pregnancies.
Real‐time coloring method of laser surgery video based on generative adversarial network
Authors: Pan Xiaoying , Lian Jia , He Qiqi , Xue Yufeng , Wang Hao , He Dalin 
Published: March 2023

AbstractLasers have become an important technology for the medical treatment of cancer. However, the high power of visible laser knives makes conventional endoscopic imaging light pollution severe. This phenomenon can cause the physician to be unable to determine the condition of the lesion site. In this article, a colorization method for laser surgery videos is proposed. The method performs real‐time colorization of the laser surgery video under black‐and‐white imaging. The main contribution of this work is to propose a new idea for solving laser contamination in medical surgery videos, along with real‐time generative adversarial networks (RTGANs). The network takes advantage of generative adversarial networks and residual networks for fast colorization of black and white images. To evaluate the method, we conducted experiments using three datasets. The experimental results show that the RTGAN network takes only 0.026 s to colorize a single frame image. Coloring speed up to 67 times faster than advanced methods, and the Peak Signal to Noise Ratio reached a maximum of 35.736.
BUS‐CAD: A computer‐aided diagnosis system for breast tumor classification in ultrasound images using grid‐search‐optimized machine learning algorithms with extended and Boruta‐selected features
Authors: Özcan Hakan 
Published: March 2023

AbstractBreast cancer has become the most prominent type of cancer in the world. Early detection of breast cancer plays an important role in optimal treatment planning to decrease mortality. Breast ultrasound is widely used in diagnosing breast masses. Applications of machine learning in ultrasound imaging‐based classification have shown promising potential for early and accurate detection of breast cancer. In this study, a new computer‐aided diagnosis system based on machine learning techniques for breast cancer classification is proposed. Feature space is extended by using hybrid feature representations that combine both global and local texture statistics. A two‐step feature selection process is implemented using Boruta all‐relevant feature selection algorithm and iterative correlation analysis. A grid‐search strategy is followed along with 20 times repeated 10‐fold randomly stratified cross‐validation to optimize machine learning algorithms. Fourteen classification models based on random forest (RF) and support vector machine trained using all combinations of global features and the features driven from gray‐level co‐occurrence matrix and local binary patterns are tested. The experiments showed that the RF classifier on the hybrid feature vector that combines all global and local features achieved the best classification performance with average accuracy and area under the curve of 97.81% and 99.80%, respectively. The results suggest that the proposed system efficiently improves the classification performance of breast lesions on ultrasound images and can assist clinical decision‐making.
Societal costs of personality disorders: A cross‐sectional multicenter study of treatment‐seeking patients in mental health services in Norway
Authors: Sveen C. A. , Pedersen G. , Ulvestad D. A. , Zahl K. E. , Wilberg T. , Kvarstein E. H. 
Published: March 2023

AbstractObjectiveThere is a relatively small body of research on the cost‐of‐illness of personality disorders (PDs). Most studies only include borderline PD. The aim of this study was to investigate mean societal costs, including its components, (direct) health service costs and (indirect) productivity loss, among treatment‐seeking patients with the broad range of all PDs according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM‐5).MethodsCross‐sectional data from 911 patients diagnosed with at least 1 PD were retrieved from the quality register of the Norwegian Network for Personality Disorders—a collaboration of PD treatment units within specialist mental health services. The patients were referred in the time period 2017–2020. Estimation of costs was based on a bottom‐up approach, using information from a structured interview covering the 6‐month period before assessment, whereas unit costs were retrieved from public reports, public records, or public agencies. The human capital approach was used to calculate productivity loss. Diagnoses were determined by semi‐structured diagnostic interviews (Structured Clinical Interview for DSM‐5‐PD [SCID‐5‐PD]).ResultsThe mean societal costs were €20.260 during the 6‐month period before specialized treatment. The largest cost component was productivity loss (65%), whereas health service costs constituted 35%. The main contributors to societal costs from the underlying health service cost components were inpatient treatment (20.5%) and individual outpatient treatment (10.5%).ConclusionSocietal costs were substantial among treatment‐seeking patients with the broad range of DSM‐5 PDs, comparable to the societal costs of schizophrenia, and significantly higher than the societal costs of both depression and anxiety disorders. The cost estimates converged with recent, register‐based cost‐of‐illness studies of different PDs but exceeded previous findings from other bottom‐up studies. Furthermore, the results underscore the importance of implementing effective and specialized treatment for patients with a broad range of PDs, not only to alleviate individual suffering but also to reduce the level of societal costs. The emphasis on productivity loss as a main contributor to the overall societal costs is substantiated, hence underlining the relevance of interventions focusing on improving occupational functioning.
Managers’ and providers’ perspectives on barriers and facilitators for the implementation of differentiated service delivery models for HIV treatment in Mozambique: a qualitative study
Authors: Moiana Uetela Dorlim , Gimbel Sarah , Inguane Celso , Uetela Onei , Dinis Aneth , Couto Aleny , Gaspar Irénio , Gudo Eduardo S. , Chicumbe Sérgio , Gaveta Sandra , Augusto Orvalho , Sherr Kenneth 
Published: March 2023

AbstractIntroductionIn 2018, Mozambique's Ministry of Health launched a guideline for a nationwide implementation of eight differentiated service delivery models to optimize HIV service delivery and achieve universal coverage of HIV care and treatment. The models were (1) Fast‐track, (2) Three‐month Antiretrovirals Dispensing, (3) Community Antiretroviral Therapy Groups, (4) Adherence Clubs, (5) Family‐approach, and three one‐stop shop models for (6) Tuberculosis, (7) Maternal and Child Health, and (8) Adolescent‐friendly Health Services. This study identified drivers of implementation success and failure across these differentiated service delivery models.MethodsTwenty in‐depth individual interviews were conducted with managers and providers from the Ministry of Health and implementing partners from all levels of the health system between July and September 2021. National‐level participants were based in the capital city of Maputo, and participants at provincial, district and health facility levels were from Sofala province, a purposively selected setting. The Consolidated Framework for Implementation Research (CFIR) guided data collection and thematic analysis. Deductively selected constructs were assessed while allowing for additional themes to emerge inductively.ResultsThe CFIR constructs of Relative Advantage, Complexity, Patient Needs and Resources, and Reflecting and Evaluating were identified as drivers of implementation, whereas Available Resources and Access to Knowledge and Information were identified as barriers. Fast‐track and Three‐month Antiretrovirals Dispensing models were deemed easier to implement and more effective in reducing workload. Adherence Clubs and Community Antiretroviral Therapy Groups were believed to be less preferred by clients in urban settings. COVID‐19 (an inductive theme) improved acceptance and uptake of individual differentiated service delivery models that reduced client visits, but it temporarily interrupted the implementation of group models.ConclusionsThis study described important determinants to be addressed or leveraged for the successful implementation of differentiated service delivery models in Mozambique. The models were considered advantageous overall for the health system and clients when compared with the standard of care. However, successful implementation requires resources and ongoing training for frontline providers. COVID‐19 expedited individual models by loosening the inclusion criteria; this experience can be leveraged to optimize the design and implementation of differentiated service delivery models in Mozambique and other countries.
Cyber racism in counseling cyberspaces
Authors: Green Darius A. , Dockery Gene N. , Williams Brittany A. 
Published: March 2023

AbstractAttention toward how technology may be used to perpetuate racism is warranted given the global impact of the COVID‐19 pandemic. We examined cyberspaces associated with the counseling profession to estimate the prevalence and impact of cyber racism using a cross‐sectional design. Results indicated that exposure to cyber racism may impact emotions and perceived inclusion in groups.
A decolonial perspective of collective coping in the adult attachment and life satisfaction link
Authors: Jin Ling , Wang Chiachih DC , Bismar Danna , Carbajal Ivan , Zhu Wenzhen 
Published: March 2023

AbstractThis study examined the role of cognitive flexibility and collective coping in the relationship between adult attachment and life satisfaction while comparing Black, Indigenous, and People of Color (BIPOC; n = 187) and White (n = 135) groups. Result showed that the relationship between attachment anxiety and life satisfaction was mediated via cognitive flexibility and collective coping only in the BIPOC group. This study informs culturally responsive attachment‐based counseling and advances literature from a decolonial perspective.