bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Co(II)–organic framework and peroxidase mimetic Hemin@metal–organic framework and its application in the colorimetric analysis of glucose
Authors: Qi Weifeng , Li Zheng , Wang Xiong , Wang Honghao , Li Xia 
Published: January 2023

A Co(II)‐organic framework (Co‐MOF), [Co3(3,5‐bimpy)2(5‐cpia)2(H2O)2], was constructed via the hydrothermal reaction of 3,5‐bis(1‐imidazoly)pyridine (3,5‐bimpy) and 5‐(2′‐carboxylphenoxy)isophthalic acid (5‐H3cpia). The Co‐MOF possessed a three‐dimensional (3D) porous architecture with the porosity of 22.4% per unit volume. The Co‐MOF@Hemin composite was further constructed via the encapsulation of Hemin into the Co‐MOF material. The constructed Co‐MOF@Hemin exhibited satisfactory peroxidase‐like activity through catalytic oxidation of the colorless peroxidase substrate 3,3,5,5‐tetramethylbenzidine (TMB) to a blue‐colored oxTMB in the presence of H2O2. Hence, the detection of H2O2 was achieved with a wide linear range from 0.005 to 0.5 mM (R2 = 0.992) and a low detection limit of 1.26 μM. More importantly, the peroxidase‐like Co‐MOF@Hemin was suitable for the sensitive and selective detection of glucose under the presence of glucose oxidase (GOx), which reduced O2 to H2O2. This analytical procedure for the detection of glucose had a linear range from 0.3 to 3 mM (R2 = 0.997), with a detection limit of 49 μM. The experimental results display the broad application prospects of the enzyme‐based MOFs in green and selective targets analyses.
May PdCu@f‐MWCNT NPs be an ecotoxicologic risk?
Authors: Alak Gonca , Yeltekin Aslı Çilingir , Köktürk Mine , Nas Mehmet Salih , Parlak Veysel , Calimli Mehmet Harbi , Ucar Arzu , Atamanalp Muhammed 
Published: January 2023

The mechanisms of various metal nanoparticles (NPs) are still a matter of debate in aquatic toxicology. In order to close this gap, the number of studies on this subject is increasing. The aims of this study are to explore the interactions of PdCu@f‐MWCNT NPs with zebrafish and get to know if it has an ecotoxicological risk. In this study, we synthesized, characterized PdCu@f‐MWCNT NPs, and investigated its ecotoxicological effects. The chemical and morphological structures of PdCu@f‐MWCNT nanomaterials were elucidated with advanced analysis techniques such as scanning electron microscope (SEM), X‐ray spectrophotometer (EDX), transmission electron microscope (TEM), and X‐ray diffraction (XRD) analyses. The ecotoxicological risks were investigated by conducting biochemical analyses and malformation defects in zebrafish. The results were obtained using multiple marker applications including oxidative stress parameters, proinflammatory cytokine expressions, DNA damage, and apoptosis markers. The obtained findings showed embryonic development, survival rate, and incidence of malformation increasing in parallel with the dose increase in zebrafish exposed to PdCu@f‐MWCNT NPs at 10–1000 μg/L levels. Despite the observed decreases in antioxidant enzyme activities, GSH level, AChE activity, and NRF‐2 level, inductions in malondialdehyde (MDA) level, IL‐6, TNF‐α, NF‐kB, DNA damage, and apoptosis levels were observed with increasing dose. Considering these findings, it has been determined that there are toxic effects in zebrafish at all levels above the concentration that we examine as a safe dose (10 μg/L). The effects of all studied concentrations of this NP above the safe dosage, especially on oxidative stress, malformation, and immune system, were found to be quite significant. The more widespread use of nanotechnology in the future will mean more contact of aquatic organisms with NPs. As a result, it is clearly seen that these organisms, which form the important link of the food chain, and the aquatic environment are living at risk conditions.
A novel and efficient CaCO3 scale inhibitor in high‐temperature and high‐salinity geothermal systems: A deprotonated quadripolymer
Authors: Qiao Shixuan , Chen Youyuan , Li Jiaxing , Li Yangpei , Peng Tao , Liang Jun , Zheng Tianyuan , Fu Kaiming , Chang Qinpeng 
Published: January 2023

AbstractScale inhibitors are effective in preventing CaCO3 scaling in geothermal systems, but the scale inhibition performance and price of commercial scale inhibitors in high‐temperature and high‐salinity water are still not ideal. In this work, a novel modified carboxymethylated β‐cyclodextrin tetrameric (CAAS) scale inhibitor was synthesized using carboxymethylated β‐cyclodextrin, acrylic acid, 2‐acrylamido‐2‐methylpropanesulfonic acid (AMPS), and p‐styrenesulfonate (SSS) by free radical polymerization, and deprotonated CAAS (D‐CAAS) was prepared based on CAAS. The results of the static test showed that the CaCO3 scale inhibition efficiency of D‐CAAS reached 90.8% at 100°C and 800 mg/L Ca2+. Compared with that of previous commercial scale inhibitors, the scale inhibition efficiency of D‐CAAS was increased by 13.5%, and the price can be decreased by 26.1%. The results of SEM, XRD and molecular dynamics (MD) simulation showed that at 100°C–120°C, the deprotonation of D‐CAAS enhanced the weak interaction between D‐CAAS and CaCO3, inducing the transformation between calcite and vaterite and forming a loose scale. Deprotonation weakens the hydrogen bond between D‐CAAS and water to reduce the energy required for the binding of D‐CAAS to the surface of CaCO3. This study is expected to provide a low‐cost and high‐efficiency CaCO3 scale inhibitor for geothermal applications.
Rational design of the S,N‐heteroacene‐based nonfullerene by introducing the fluorine atom for efficient high‐performance organic solar cells
Authors: Oh Sora , Amjad Mufarah , Ahn Taek , Lee Sang Kyu 
Published: January 2023

AbstractFluorination has been established as an effective structural modification strategy to influence properties and has attracted attention in organic solar cells. Here, we design and synthesize three fused‐ring electron acceptors based on ladder‐type pentacyclic heteroacenes as the electron‐rich unit and 1,1‐dicyanomethylene‐3‐indanones with 0–2 fluorine substituents as the electron‐deficient units. Among these three molecules, two fluorine substituents nonfullerene acceptor, DTP‐2F exhibit strong absorption with high extinction coefficients and deep HOMO and LUMO level as compared with DTP‐0F and DTP‐1F. Device studies show that fluorinated nonfullerene acceptors (NFAs) lead to reduced VOC but increased JSC and FF, and therefore, the ultimate influence to efficiency depends on the compensation of VOC loss and gains of JSC and FF. Furthermore, fluorination affect to film morphology and miscibility between donor and acceptor. The fluorination of NFAs is one of the best design method of the donor and acceptor materials for efficient high‐performance organic solar cell.
Brain abscess due to Nocardia asiatica in a 63‐year‐old patient with adult‐onset still disease: A case report
Authors: Salazar Reinoso Fernando Raul , Romero‐Santana Gioconda Stefania , Mawyin Juez Andrea Emilia , Calderon Navas Jorge Andrés , Ronquillo Piloso Andrés Santiago 
Published: January 2023

AbstractCerebral nocardiosis is a rare and opportunistic cerebral infection caused by Nocardia spp., a gram‐positive, aerobic bacteria of the Actinomycetes order. Patients with cell‐mediated immunodeficiencies are often targeted by this microorganism, for which early diagnosis and therapeutic approach are essential.
Ni3S2@MoS2@Ni3Si2 Seaweed‐like Hybrid Structures In‐situ Grown on Ni Foam as Efficient Bifunctional Electrocatalysts
Authors: Xu Xuequan , Zhao Xuewen , Zhao Rongzheng , Gu Mengyue , Cheng Yonghong , Zhang Jinying 
Published: January 2023

AbstractWater electrolysis is a promising method for sustainable hydrogen production. The exploration of noble metal free bifunctional electrocatalysts with both good hydrogen evolution reaction (HER) and oxygen evolution reaction (OER) catalytic activity is crucial for efficient overall water splitting. The design of electrocatalysts to enhance electrocatalytic performance for both HER and OER is still a big challenge. Long Ni3Si2 nanowires have been in‐situ grown on Ni foam by low pressure chemical vapor deposition. A facile hydrothermal method was then adopted to grow Ni3S2@MoS2@Ni3Si2 seaweed‐like structures with high active sites on the Ni3Si2 blades and high charge transport along central stipes. The as‐produced Ni3S2@MoS2@Ni3Si2 seaweed‐like hybrid structures have been demonstrated to have both excellent HER and OER catalytic performance as integrated electrodes. Low overpotentials of 84 mV (η10)/283 mV (η50) and Tafel slopes of 36.0/53.7 mV dec−1 have been achieved for HER/OER, respectively. Excellent long‐term stabilities have been obtained for both HER and OER.
Ultralong nitrogen/sulfur Co‐doped carbon nano‐hollow‐sphere chains with encapsulated cobalt nanoparticles for highly efficient oxygen electrocatalysis
Authors: Zhang Wei , Guo Xingmei , Li Cong , Xue Jiang‐Yan , Xu Wan‐Ying , Niu Zheng , Gu Hongwei , Redshaw Carl , Lang Jian‐Ping 
Published: January 2023

AbstractThe development of simple and effective strategies to prepare electrocatalysts, which possess unique and stable structures comprised of metal/nonmetallic atoms for oxygen reduction reaction (ORR) and oxygen evolution reaction (OER), is currently an urgent issue. Herein, an efficient bifunctional electrocatalyst featured by ultralong N, S‐doped carbon nano‐hollow‐sphere chains about 1300 nm with encapsulated Co nanoparticles (Co‐CNHSCs) is developed. The multifunctional catalytic properties of Co together with the heteroatom‐induced charge redistribution (i.e., modulating the electronic structure of the active site) result in superior catalytic activities toward OER and ORR in alkaline media. The optimized catalyst Co‐CNHSC‐3 displays an outstanding electrocatalytic ability for ORR and OER, a high specific capacity of 1023.6 mAh gZn−1, and excellent reversibility after 80 h at 10 mA cm−2 in a Zn‐air battery system. This work presents a new strategy for the design and synthesis of efficient multifunctional carbon‐based catalysts for energy storage and conversion devices.
[ReH3(PPh3)4] – A Key Compound in the Rhenium Hydride Chemistry
Authors: Roca Jungfer Maximilian , Abram Ulrich 
Published: January 2023

AbstractThe chemistry of the rhenium trihydrido complex [ReH3(PPh3)4] (1) has been reinvestigated. An improved synthesis and the solid‐state structure of the compound as well as several reactions are reported. The solid‐state structure of 1 is similar to that of [TcH3(PPh3)4] having a capped‐octahedral coordination sphere. The PPh3 ligands surround the Re atom in a trigonal‐pyramidal mode with a short apical Re−P bond (2.300(2) Å) and three longer basal bonds (2.429(2)–2.449(2) Å). Reactions of 1 with monodentate phosphines such as PMe3 or PBu3 give the mono‐substituted complexes [ReH3(PPh3)3(PMe3)] (2) and [ReH3(PPh3)3(PBu3)] (3) under retention of the apical PPh3 ligand and substitution of one of the basal PPh3 ligands. The stability of the phosphine trihydride complexes decreases in the order PPh3>PMe3>PBu3. Treatment of [ReH3(PPh3)4] with trityl hexafluorophosphate in CH3CN does not result in a hydride abstraction, but gives the tetrahydrido cation [ReH4(NCCH3)(PPh3)3]+ (4), while reactions with nitriles give unstable azavinylidene complexes of the composition [ReH2(PPh3)3(NC(H)R)] (5). They are formed by an insertion of the nitrile into a Re−H bond. The solid‐state structure of the methyl derivative [ReH2(PPh3)3(NC(H)CH3)] (5 a) was determined showing a linear Re−N−C unit with rhenium−nitrogen and nitrogen−carbon double bonds, while the N=CH−C bond is clearly bent with an angle of 124°. Two previously unknown polymorphs of [ReH5(PPh3)3] were isolated from reactions of 1 with HOC6H3(CH3)2 and thiourea after prolonged heating in toluene and characterized by IR spectroscopy and X‐ray diffraction.
Enzyme‐Assisted Extraction of Alginate from Beach Wrack Fucus vesiculosus
Authors: Malvis Romero Ana , Brozio Felix , Kammler Sinah , Burkhardt Christin , Baruth Leon , Kaltschmitt Martin , Antranikian Garabed , Liese Andreas 
Published: January 2023

AbstractBeach wrack constitutes an unutilized, abundant renewable source of marine macro algae being rich in valuable biopolymers. This work investigates the revalorization of the brown algae Fucus vesiculosus collected from beach wrack as a source of alginate, the main polysaccharide in brown algae which constitutes a potential ingredient for the development of biopolymer films. Enzyme‐assisted extraction has been investigated for cell disruption with commercial cellulase blends and proteases. The effect of enzyme type, enzyme activity, and extraction time on alginate yields, molecular weight distribution, functional groups, and purity has been studied.
Ethnic disparities in the immune microenvironment of triple negative breast cancer and its role in therapeutic outcomes
Authors: Zajac Kelsee K. , Malla Saloni , Babu Ramapuram Jayachandra , Raman Dayanidhi , Tiwari Amit K. 
Published: January 2023

AbstractIn 2020, newly diagnosed breast cancer (BC) cases surpassed that of lung cancer among women, making it the most common female cancer globally. In spite of recent increases in incidence rates, mortality due to BC has declined since 1989. These declines have been attributed to advancements in treatment modalities as well as increased mammography surveillance. Despite these advances, African American (AA) women are 40% more likely to die from BC than Caucasian women. Multifactorial etiology has been implicated in the disparity of BC mortality rates among AA women. As an example, AA women have a disproportionate incidence of triple negative breast cancer (TNBC), which has a poor prognosis and marginal treatment options. Increasingly, the tumor microenvironment (TME) has gained relevance as it relates to primary tumor progression, metastasis and treatment possibilities. The treatment outcomes or pathological complete response (pCR) in TNBC among AA women are affected by differences in TME. The TME of AA women exhibit several variances in acellular and cellular components associated with pro‐tumorigenic effects. For example, increased levels of the adipocyte‐related hormone, resistin, the pro‐inflammatory cytokine, IL‐6, and the CC chemokine, CCL2, within the TME of AA women gives rise to an increased density of M2 macrophages, also known as tumor‐associated macrophages. Elevated levels of vascular endothelial growth factor in the TME of AA women increase the vascular density or vascularity, which facilitate aggressive tumor growth and metastasis. Furthermore, a pro‐tumorigenic TME is supported by increased levels of the CXC chemokine, CXCL12 that results in the recruitment of regulatory T lymphocytes (Tregs). Due to these and other differences in the TME of AA women, precision oncology can target specific aspects of the TME that may contribute to a poorer prognosis. In addition to the discrepancies in the TME, AA women face socio‐economic barriers that limit their ability to access state‐of‐the‐art, novel therapies against metastatic TNBC. In this review, we will provide a brief overview of the tumor immune microenvironment, immune‐based treatment options for TNBC and their potential to decrease health disparities due to ethnicity.
Physicochemical Analytical Studies on Yttrium‐Doped Triglycine Sulfate Single Crystals
Authors: Rafi Ahamed S. , Suppuraj P. , Balakrishnan C. , Kalpana S. 
Published: January 2023

AbstractSingle crystals of pure triglycine sulfate (TGS) and yttrium‐acetate (0.5 mol%)‐doped triglycine sulfate (YTGS) crystals are synthesized and the crystals are grown from aqueous solution by slow evaporation solution growth method. The grown crystals are subjected to single crystal and powder X‐ray diffraction studies to identify the morphology and structure. Both the grown crystals are packed in a monoclinic crystal system and the lattice parameters of YTGS crystal are a = 9.138 Å, b = 12.72 Å, and c = 5.728 Å, whereas the doped TGS are, a = 9.134 Å, b = 12.61 Å, and c = 5.723 Å. The lattice parameters are slightly distorted due to the incorporation of yttrium ion into the lattice sites of the TGS crystal. The thermal stability of the grown crystals is investigated by differential thermal analysis (DTA) and thermogravimetric studies. DTA curve shows a lower decomposition temperature for YTGS crystal than for pure TGS crystal. The functional groups of the grown crystals are identified by Fourier transform infrared spectral studies. The surface morphology of the crystals is examined by scanning electron microscopy. Dielectric studies are carried out to identify the phase transition temperature and to find the dielectric constant of the YTGS crystals.
Tailoring the Chemical Structure of Nitrogen‐Doped Carbon Dots for Nano‐Aminocatalysis in Aqueous Media
Authors: Gentile Giuseppe , Mamone Martina , Rosso Cristian , Amato Francesco , Lanfrit Chiara , Filippini Giacomo , Prato Maurizio 
Published: January 2023

AbstractAmine‐rich carbon dots (NCDs) have become promising nano‐aminocatalytic platforms in organic synthesis. These nanomaterials can be effectively produced through straightforward bottom‐up approaches using inexpensive nitrogen‐containing molecular precursors as a starting material. However, to date, there is still a limited understanding of how the molecular features of these precursors affect the catalytic activity of the resulting nanoparticles. This study concerns the production of a new family of NCDs, which use l‐arginine and different alkyl diamines as starting materials. The surface amines of all these NCDs were comprehensively characterized, thus allowing us to provide a correlation between the structural features of the nanoparticles and their catalytic performance with a selected amino‐catalyzed organic transformation. Importantly, the most active nano‐aminocatalysts, namely, NCDs‐3, were then used as a basis for the formation of a wide variety of functionalized organic compounds in water under mild reaction conditions.
Optimization of the “in‐silico” mate‐pair method improves contiguity and accuracy of genome assembly
Authors: Zhou Tao , Lu Liang , Li Chenhong 
Published: January 2023

AbstractA combination of short‐insert paired‐ended and mate‐pair libraries of large insert sizes is used as a standard method to generate genome assemblies with high contiguity. The third‐generation sequencing techniques also are used to improve the quality of assembled genomes. However, both mate‐pair libraries and the third‐generation libraries require high‐molecular‐weight DNA, making the use of these libraries inappropriate for samples with only degraded DNA. An in silico method that generates mate‐pair libraries using a reference genome was devised for the task of assembling target genomes. Although the contiguity and completeness of assembled genomes were significantly improved by this method, a high level of errors manifested in the assembly, further to which the methods for using reference genomes, was not optimized. Here, we tested different strategies for using reference genomes to generate in silico mate‐pairs. The results showed that using a closely related reference genome from the same genus was more effective than using divergent references. Conservation of in silico mate‐pairs by comparing two references and using those to guide genome assembly reduced the number of misassemblies (18.6%–46.1%) and increased the contiguity of assembled genomes (9.7%–70.7%), while maintaining gene completeness at a level that was either similar or marginally lower than that obtained via the current method. Finally, we developed a pipeline of the optimized in silico method and compared it with another reference‐guided assembler, RagTag. We found that RagTag produced longer scaffolds (17.8 Mbp vs 3.0 Mbp), but resulted in a much higher misassembly rate (85.68%) than our optimized in silico mate‐pair method. This optimized in silico pipeline developed in this study should facilitate further studies on genomics, population genetics, and conservation of endangered species.
Dynamic disequilibrium: Recent widespread increases in vegetation cover on subarctic floodplains of Interior Alaska
Authors: Frost Gerald V. , Roland Carl A. , Schmidt Joshua H. 
Published: January 2023

AbstractBoreal forest and tundra ecosystems are undergoing rapid climatic and environmental changes with consequences for ecosystem structure, function, and services. Although riparian zones occupy a small footprint within subarctic landscapes, they have disproportionately high value as foci of hydrological processes, biogeochemical cycling, ecological disturbance, biodiversity, and wildlife activity. Recent observations of increased winter discharge, reduced peak flows, and increased connectivity between catchments, streams, and groundwater in subarctic riparian zones have prompted predictions of altered riverine disturbance regimes, increased channelization, and a decline in the extent of active floodplains. However, few observational data exist concerning the spatiotemporal dynamics of subarctic floodplain vegetation, which can serve as a bioindicator to corroborate such predictions. We analyzed the distribution and extent of riparian ecotypes across a network of streams in 12 Interior Alaska watersheds using high‐resolution image pairs from circa 1981–2010. All stream reaches encompassed pronounced elevational gradients and included elevational forest–tundra ecotones. We classified riparian ecotypes using an image‐based point‐intercept sampling approach, calculated the probability of ecotype transitions, and evaluated relationships between ecotype transitions and environmental covariates. Our results reveal widespread increases in the stature, density, and extent of riparian vegetation spanning gradients of elevation, floodplain morphology, and climate. Ecotype transitions occurred at >20% of sample points, and there was a strong imbalance toward forward successional transitions (16.5%) versus backward transitions (4.0%). That is, we observed a strong tendency toward increasing cover, stature, and density of vegetation communities across our extensive sampling domain across our approximately 30‐year sample period. This relatively rapid riparian “greening” signal tended to be most pronounced in our glaciated watersheds. Although the streams we studied displayed high local variability in ecotype transitions, our results support hypotheses of increasing channelization and reduced extent of unvegetated surfaces on subarctic floodplains. They also likely reflect a trend toward more rapid and extensive plant recruitment and growth due to processes associated with conspicuous warming in northern ecosystems, consistent with greening documented in other subarctic landscape segments along gradients of elevation and latitude.
Simple Access to 2‐Arylbenzo[b]tellurophenes
Authors: Paegle Edgars , Arsenyan Pavel 
Published: January 2023

AbstractArguably, the simplest way for the preparation of benzo[b]tellurophenes has been elaborated. Cyclization of o‐haloarylalkynes in the presence of Te‐NaOH‐DMSO triad occurs by simple mixing of starting materials and heating overnight without the need for dry and inert atmosphere and provides the corresponding benzo[b]tellurophenes in up to 90 % GC‐yield. Catalytic telluration of aryl iodide substrates extends the applicability of the developed cyclization cascade to substrates that are not suitable for the direct SNAr/5‐endo‐dig cyclization approach. Successful SEAr in the third position of benzo[b]tellurophene provides a synthetic intermediate for the preparation of Te analogues of selective estrogen receptor modulator (SERM) raloxifene.