bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unexpected worker mating and colony-founding in a superorganism
Authors: Li Jilian , Zhuang Mingsheng , Colgan Thomas , Guo Yulong , Zhang Zhengyi , Liu Fugang , Xia Zhongyan , Dai Xueyan , Zhang Zhihao , Li Yuanjian , Wang Liuhao , Xu Jin , Guo Yueqing , Qu Yingping , Yao Jun , Yang Huipeng , Yang Fan , Guo Jun , Brown Mark 
Published: February 2023

Abstract
The emergence of superorganisms in ants, termites, bees, and wasps1 represents a major transition in evolution2. Pre-imaginal caste determination, leading to reproductively dominant queens, which mate, store sperm, and lay fertilized eggs, and lifetime unmatedness of worker castes are key features of these animal societies1. While workers in superorganismal species like honey bees and many ant species have consequently either lost, or retain only vestigial spermathecal structures, workers in the bumble bees, wasps and certain ant subfamilies retain complete spermathecae3,4,5. In the case of bumble bees, the retention of these structures in workers and whether they remain reproductively functional despite 25-40 million years of evolution6, is an evolutionary mystery. Here we show that bumble bee workers have retained queen-like reproductive traits. We demonstrate through artificial insemination experiments that worker spermathecae are functional, and that their gene expression post-insemination mirrors that of queens. Further, we show that inseminated workers can rear colonies and produce female offspring throughout the colony life-cycle, an act previously believed to be the sole domain of queens. Mating experiments identified that social isolation is a trigger for successful mating, with social interactions with brood, workers, or queens inhibiting mating. Subsequent semi-field experiments showed that workers can naturally mate in de-queened colonies and go on to produce queen offspring. In the wild, this may act as a back-up strategy to maintain colonies in response to the early loss of the queen. Our results demonstrate that bumble bee workers retain the ability to function as queens, resolving the paradox of why workers in certain taxa maintain intact spermatheca which never mate, and suggesting that worker lifetime unmatedness is not a pre-requisite for the evolutionary transition to superorganisms. Our finding also provides an exciting new tool to combat global declines in bumble bees through artificial insemination of workers from rare and declining species and could therefore have applications in protecting bumble bee biodiversity.
WITHDRAWN: Creating Value Differently in the Third Sector in Morocco: Analytical Study in the Light of a Non-profit Women's Association for Independent Advocacy
Authors: TAGHZOUTI Abdellatif , ELQOURI Abdelouahed , ASSAIDI Abdelouahid , LAADEM Meryem , KABAK Saad 
Published: February 2023

Abstract
This article aims to highlight an atypical form of entrepreneurship in a solidarity environment, which is related to the creation of income generating activities (IGA) in a non-profit organization context. Therefore, we will try to show that the women’s associative entrepreneurship could be a significant lever of action not only to create income-generating activities, but also as a fertile field to put female entrepreneurs, "co-opted" within a non-profit organization, on a multi-purpose value creation path. Our concern, in this article, is to rethink the traditional model of value management created by IGAs by expanding it through a multidimensional vision, with the example of a specific non-profit organization: the Initiative for the Protection of Women's Rights (IPWR). We seek to identify the value-creating activities of this non-profit organization in an entrepreneurial process, through solidarity projects led by women exposed to violence. This study makes it possible to evolve efficiently and effectively the current and future value creation of non-profit organizations promoting IGAs carried out by abused women. One of the key findings of our study is that through these entrepreneurship initiatives within non-profit organizations, these abused women recovered or gained self-confidence, accepted the idea that their life have a meaning, and felt valued by becoming autonomous both on material and immaterial dimensions. Our research approach is part of an hybrid exploration. Data collection was conducted through field observations, open interviews and documentation.
The SGLT2i-mediated regulation of cardiovascular and safety outcomes among patients with chronic kidney disease: A systematic review and meta-analysis of randomized controlled trials
Authors: Zhou Yi , Wang Fengrong , Wen Feifei , Li Chao , Ye Tingting 
Published: February 2023

Abstract
Backgrounds: To assess the impact of SGLT2i on the cardiovascular and safety outcomes of patients with chronic kidney disease (CKD).
Methods: Eligible articles were chosen via a systematic search of the PubMed, Embase, and Cochrane electronic databases. We screened for randomized placebo-controlled clinical trials (RCTs) investigating the outcome of SGLT2i on patients with CKD. The main cardiovascular outcomes were major adverse cardiovascular events (MACE), which involved non-fatal myocardial infarction, non-fatal stroke and cardiovascular death, cardiovascular death and hospitalization for heart failure. On the other hand, acute renal injury, hypoglycemia, diabetic ketoacidosis, and amputation were considered as safety indicators for this trial. Renal insufficiency was defined as eGFR<90 mL per minute per 1.73m2. In case the heterogeneity outcome index was ≥50%, we conducted sensitivity analysis on relevant data to ensure the reliability of our conclusions.
Results: Overall, 7 articles, involving 26739 total participants, conformed to our inclusion and exclusion criteria. Compared to placebo, SGLT2i significantly modulated cardiovascular outcomes MACE (OR: 0.76 95% CI: 0.68 to 0.86 I2:40.7% P: 0.168), cardiovascular death (OR: 0.83 95% CI: 0.72 to 0.95 I226.4% P: 0.236), and hospitalization for heart failure (OR: 0.67 95% CI: 0.60 to 0.76 I2:0.0% P: 0.538), as well as safety outcomes, such as, acute renal injury (OR: 0.83 95% CI: 0.68 to 1.00 I2:0.0% P: 0.576), hypoglycemia (OR: 0.88 95% CI: 0.73 to 1.07 I2:18.4% P: 0.297), diabetes ketoacidosis (OR: 2.57 95% CI: 1.50 to 4.41 I2:46.3% P: 0.133), and amputation (OR: 1.09 95% CI: 0.87 to 1.36 I2; 0.0% P: 0.703).
Conclusion: In patients with CKD, SGLT2i usage markedly diminished incidences of cardiovascular outcomes MACE, cardiovascular death and hospitalization for heart failure. In addition, it also reduced the related risks of safety outcomes, such as, acute renal injury, hypoglycemia, diabetic ketoacidosis, and amputation. However, since the safety outcome selection was not complete in this trial, further investigations are necessary to assess all safety outcomes among a larger patient population.
DF-Phos: Prediction of Protein phosphorylation Sites by Deep Forest
Authors: Zahiri Zeynab , Mehrshad Nasser , Mehrshad Maliheh 
Published: February 2023

Abstract
Background
Phosphorylation is the most important and studied post-translational modification (PTM), which plays a crucial role in protein function studies and experimental design. Many significant studies have been performed to predict phosphorylation sites using various machine-learning methods. Recently, several studies have claimed that deep learning-based methods are the best way to predict the phosphorylation sites because deep learning as an advanced machine learning method can automatically detect complex representations of phosphorylation patterns from raw sequences and thus offers a powerful tool to improve phosphorylation site prediction.
Results
In this study, we report DF-Phos, a new phosphosite predictor based on the deep forest to predict phosphorylation sites. In DF-Phos, the feature vector taken from the CkSAApair method is as input for a deep forest framework for predicting phosphorylation sites. The results of 10-fold cross-validation show that the deep forest method has the highest performance among other available methods.
Conclusions
We implemented a python program of DF-Phos, which is freely available for non-commercial use at https://github.com/zahiriz/DF-Phos Moreover, users can use it for various PTM predictions.
People, Culture, and Environment of a Middle Holocene in Maros Regency, Indonesia
Authors: Hasanuddin Hasanuddin , Bernadeta Apriastuti K.W. , Supriadi Supriadi , Saiful A. M. , Suryatman Suryatman , Rustan Rustan 
Published: February 2023

Abstract

This research aimed to find the human life and the relationship between culture and environment in Mallawa, Maros Regency (South Sulawesi), Indonesia, in the past. The methods used were survey, excavation, and some analyses, namely radiocarbon dating, residue analysis, technical analysis of artifacts (stones and bones), analysis of the Number of Identified Specimens (NISP), and analysis of Minimum Number of Individuals (MNI). The survey found a cave (“Liang” in the local language) that has two pieces of rock art in the form of hand stencils on its walls. In 2021 an excavation was carried out in Liang (cave) Sumpang Karoro 1. Human skeletons were found at a depth of 85 cm. They were in association with Maros Point artifacts flakes, animal bones, and ochre. The radiocarbon analysis shows that the humans with whom the remains were in association lived in the area around 7424-7260 cal BP. The finds of human skeletons are very important because they represent the few finds of human skeletons from the Holocene period and because the humans from whom the skeletal remains are from may have had the same ancestors as contemporary Australasian peoples. The pollen analysis shows that the site’s environment consisted of open lowland rainforests with bushes far from a coastal watershed.
Linking Entrepreneurial Orientation, Learning Orientation, Organization Structure and the Growth of Government
Authors: Alyammahi Alyaa Hamed , Sarker Abu Elias , Zervopoulos Panagiotis 
Published: February 2023

Abstract
The purpose of this article is to develop a research framework for clearly understanding the factors that propel the growth of government. Based on an extensive review of literature, it is found that despite the call for small governments by the proponents of neo-liberal market ideology, the growth of government remains unabated. Extant literature in business management and public sector entrepreneurship stipulates that entrepreneurial orientation in tandem with learning orientation and organizational structure plays critical roles in augmenting the growth of government. The new research framework will serve as a springboard for vigorous empirical research in any context.
Barriers to Diagnosis of Postpartum Depression among Younger Black Mothers
Authors: Dwarakanath Megana , Hossain Fahmida , Balascio Phoebe , Moore Mikaela C. , Hill Ashley V. , De Genna Natacha M. 
Published: February 2023

Abstract
Objective: The objective of this study was to qualitatively examine coping mechanisms and desired supports in pregnant and birthing Black and biracial adolescent and young adult women during the COVID-19 pandemic.
Method: Black and biracial participants ages 16-23 were recruited for virtual individual semi-structured interviews. Participants (n=25) were asked about pre- and post-natal experiences with the healthcare system, effects of the pandemic, and participants’ experiences of or desires for ideal care within the healthcare system. Interviews were transcribed verbatim and coded for qualitative analysis using nVivo. Discussions around postpartum mental health evolved organically when asked about how participants were coping postpartum.
Results: Nearly half the interviewees reported mental health symptoms consistent with postpartum depression (PPD). Of the 11 interviewees who reported mental health symptoms consistent with PPD, 2 were afraid to disclose their symptoms to a healthcare provider due to fear of child protective services involvement and their belief they would be treated unfairly because of their race.
Conclusion: Clinicians who care for Black and biracial adolescent and young adult mothers must be particularly attuned to structural barriers for appropriate screening and treatment of postpartum depression. Expanding investigations of intersectional influences on young mothers’ perinatal health and PPD are needed.
Comparison of end-of-survival below-knee and above-knee amputations with demographic, comorbidity and hematological parameters
Authors: Hançerli Cafer Özgür , DOĞAN NECATİ 
Published: February 2023

Abstract
Introduction: In this study, it was aimed to establish mortality predictive parameters with a higher contribution to mortality by comparing the demographic data, comorbid factors and hematological values of patients who underwent below-knee and above-knee amputation at the end of survival.
Materials and Methods: Eighty-seven patients who were amputated with the diagnosis of diabetic foot between March 2014 and January 2022 and resulted in mortality due to natural causes during follow-up were included in the study. Those who were amputated below the knee were named Group 1 (50 patients), and those who were amputated above the knee were named Group 2 (37 patients). The patients' age, gender, side, comorbid diseases, ASA score, anesthesia type, time to surgery, total hospital stay, CCI (Charlson comorbidity index), ex time and hematological values at the time of first admission were compared in both groups and statistical analysis was performed.
Results: Group 1 and Group 2 had similar distribution in terms of age, gender, side of operation, number of comorbid diseases, time to surgery and CCI (p>0.05). Group 2's mean ASA score, rate of admission to general anesthesia, total hospital stay and crp level were statistically higher than Group 1 (p<0.05). Ex time, albumin value and HgA1c level were statistically lower in Group 2 compared to Group 1 (p<0.05). There was no significant difference in hemogram, wbc, % lymphocyte, % neutrophil, creatinine and Na values of both groups at the time of first application (p>0.05).
Conclusions: It was seen that high ASA score, low albumin value and high crp value were significant predictors of high mortality. Creatinine level and HgA1c value were quite unsuccessful in predicting mortality.
Levels of evidence: Level 3, Retrospective comparative study
A multibody kinematic system approach for the design of shape-morphing mechanism-based metamaterials
Authors: de Jong Pier , Schwab A. , Mirzaali Mohammad J. , Zadpoor Amir A. 
Published: February 2023

Abstract
A shape-morphing structure can deform in many different ways and match different target shapes. This versatility is of great advantage for many applications but can also introduce challenges in terms of predicting the envelope of possible matching behaviors. Here, we present a method to assess the shape-matching behavior of shape-morphing structures. The developed technique utilizes a multibody systems approach wherein the structure is represented using a collection of nodes and their associated constraints. Such a representation preserves the kinematic properties of the original structure while allowing for a rigorous treatment of the shape-morphing behavior of the underlying metamaterial. This approach enables us to perform 3D simulations for a multitude of structures and target shapes. We assessed the utility of the proposed method by applying it to a wide range of sample shape-morphing structures. A modular system of joints and links was also 3D printed for the experimental realization of the systems under study. Both our simulations and the experiments performed using the modular system confirmed the ability of the presented technique to capture the true shape-morphing behavior of complex shape-morphing metamaterials.
Financial anxiety, financial self-efficacy, and general social supports: Reliability of assessments
Authors: Dickson Tara , Mulligan Edward P. 
Published: February 2023

Abstract
Background: Educational debt continues to increase across the health professions. Financial self-efficacy and generalized social supports are suggested as possible ways to mitigate the financial anxiety that results from high levels of debt. Assessment tools have not been evaluated for reliability among any group of health professions students. The purpose of this study was to assess the reliability of tools measuring financial anxiety, financial self-efficacy, and general social support in a graduate health profession student population.
Methods: The Financial Anxiety Scale, Financial Self-Efficacy Scale, and General Social Support Scale was completed by 510 physical therapist students. Item response theory was used to assess reliability and item fit for each assessment.
Results: The Financial Anxiety Scale, Financial Self-Efficacy Scale, and General Social Support Scale are reliable measures and demonstrate good item fit among the population of physical therapist students in the United States.
Conclusions: Because the results of an item response theory analysis are not dependent on the population studied, the assessments may be reliable among other health professions students. The Financial Anxiety Scale and Financial Self-Efficacy Scale provide a large amount of test information for physical therapist students. The General Social Support Scale, by contrast, may be best utilized as a screening tool for those who have very low levels of general social supports.
Changing Arctic landscapes in a changing climate: thermokarst evolution in polygonal tundra
Authors: Khattak Ahmad Jan , Hamm Alexandra 
Published: February 2023

Abstract
Ice wedges are ubiquitous features in high-latitude permafrost regions and are vulnerable to warming. Rapid changes in Arctic polygonal tundra landscapes due to melting of ice wedges, a process known as thermokarst, have significant impacts on infrastructure as well as hydrology. Despite the increased attention in recent field and modeling studies, models generally used for global climate predictions often lack the representation of thermokarst processes, leading to unreliable projections about the impact of warming on Arctic ecosystems. Here we use an integrated permafrost thermal hydrology model to simulate thermokarst evolution in six Arctic locations across a range of climates and landscapes using projected RCP8.5 climate scenario. Our model shows that widespread landscape changes will continue in the Arctic during the 21st century. These changes are likely to be more rapid (2–3 times) in warm and/or ice-rich permafrost than in cold and/or ice-poor permafrost regions. This suggests that local permafrost temperatures and ground ice will play a determining role in the future tundra landscape evolution. There is therefore a need to represent thermokarst processes in large-scale models to better understand how rising temperatures may alter Arctic tundra landscapes, which will have severe implications for its ecosystem.
Early Fever in Patients with Primary Intracerebral Hemorrhage is Associated with Worse Long-Term Functional Outcomes: A Prospective Study
Authors: Tseng Wen-Che , Chiu Yi-Hsiang , Chen Yun-Chang , Chen Hsin-Shui , Hsiao Ming-Yen 
Published: February 2023

Abstract
Background
Primary intracerebral hemorrhage (ICH) accounts for 85% of ICH cases and is associated with high morbidity and mortality rates. Fever can cause secondary injury after ICH; however, relevant studies have reported inconsistent results regarding the effects of fever on functional outcomes after ICH. This study examined the effects of early fever on the prognosis of ICH, particularly on long-term functional outcomes.
Methods
This prospective study recruited patients with primary ICH at a tertiary medical center between 2019 and 2021. Early fever was defined as a tympanic body temperature of ≥ 38°C upon admission. Barthel Index (BI) and modified Rankin scale (mRS) were examined at 1 year after ICH. A BI of ≤ 60 or mRS of ≥ 4 was considered as indicating severe disability.
Results
We included 100 patients, and early fever was significantly associated with less functional independence at 1 year post-ICH, as determined using the mRS (p = 0.048; odds ratio [OR] = 0.23), and with severe functional dependency at 1 year post-ICH, as determined using the BI (p = 0.043; OR = 3) and mRS (p = 0.045; OR = 3). In addition, patients with early fever had a longer length of hospital stay (p = 0.002; 95% confidence interval = 21.80–95.91).
Conclusions
Fever is common among patients with primary ICH. Our data indicate a significant association between early fever and worse functional outcomes in ICH survivors at 1 year after ICH. Additionally, patients with early fever had a significantly longer length of hospital stay after ICH.
Temporal Modeling and Analysis to the Variations and Trending of Haze in China
Authors: Wang Yi , Pu Liming , Yang Miao , Liu Mingxing , Peng Hao , Liang Jian 
Published: February 2023

Abstract

The country's rapid industrialization and urbanization have aggravated air pollution. Especially in recent years, the haze problem in China has attracted increasing attention from government officials, industry leaders, academic researchers and the public. To this end, five typical Chinese cities were picked to analyze and reveal the haze evolution so that providing prior knowledge for multiple regions of China. Time series data of Particulate Matter 2.5, i.e., PM2.5, which is deemed as the major contributor to haze formation, are investigated for haze trending and variation analyses. Additionally, the main variables which are closely related to the concentration of PM2.5, including both meteorological and chemical factors, are identified. The daily and monthly averages of PM2.5 concentrations are evaluated and analyzed in terms of time series analysis methods, including the seasonal decomposition and Auto-regression Integrated Moving Average (ARIMA) methods. More importantly, qualitative analysis about the influence of Chinese policies on atmospheric environment and air pollution control are discussed.