bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk factors and health-seeking behaviours in non-communicable diseases among a community sample of women
Authors: John Bindu , Marath Usha , Babu Aleena , Jiji Anit , Babu Anitta , Joshy Anu , Athira PR  
Published: February 2023

: The global burden of non-communicable diseases (NCDs) had increased tremendously, causing increased morbidity, mortality and disability among population. Cardiovascular diseases remain as a major NCD affecting public health, accounting for 23% and 30% of the total mortality in rural and urban population, respectively, in India. Health-seeking behavior of women is an important factor in tackling NCDs as it can influence the health of the family, through influencing lifestyle and related changes in preventing NCDs.: A descriptive cross-sectional survey design was used. A total of 100 women were selected using a convenience sampling method. Data was collected using questionnaires to collect demographic information, NCD risk factors, and a rating scale for assessing the health-seeking behaviors.Forty-seven percent of the participants were diabetic, 45 had hypertension and 28 of them were having dyslipidaemia. Forty-six of them had a family history of NCDs, 68 of them performed regular exercises, such as walking, 56 of them followed a mixed diet, and 63 had a preference to sweets, and 40 percent had a habit of dining out on a regular basis. A majority of the participants followed medicines and the prescribed treatment regimen directed by their physician. Only fifty percent of them engaged in leisure time activities during their free time and very few participants practiced methods like yoga, or meditation.: The participants had risk factors contributing to NCDs, and in general, were practicing good health-seeking behaviors. However, targeting on modifiable risk factors, continuously maintaining health determinants to continuous quality of life improvement is essential to curtail the further deterioration and complication of NCDs.
Physical and psychosocial wellbeing of elderly during COVID-19
Authors: Joseph Jasmine , Marath Usha , Sinny Neelima , Babu Rosemary , Shibu Sandra Maria , Jose Shany , Poulose Sonu 
Published: February 2023

: Covid-19, the global pandemic has come and without differentiating, it altered the lifestyle of people everywhere and changed older people daily routines, the care and support they received, their ability to stay socially connected and how they were perceived. The present study aimed to find the physical and psychosocial wellbeing of elderly during covid 19 pandemic.: A quantitative approach with descriptive design was used. 100 elderly (aged between 60 -80) who were not diagnosed with Covid 19 were selected using a convenience sampling technique. Data was collected using semi structured questionnaire to find the physical and psychosocial wellbeing of elderly during COVID 19, using self-report technique. The physical health of only 44% of subjects was satisfactory during pandemic. Eighty percent reported changes in their weight. Majority had slept less than 7 hours and duration of day time naps increased among 13% of elderly. Thirty percent missed their regular exercise during pandemic. Majority followed COVID- 19 guidelines. Thirty percent missed their medical tests and 37% missed their medical check-ups. Eighty-six percent of elderly did not avail the telemedicine facility. Sixty-five percent were satisfied with their life during the pandemic. Forty percent found difficulties in maintaining close relationships during pandemic. More than half of elderly experienced anxiety and fear of death. Seventy-two percent were mentally exhausted. Fifty-four percent were worried when family, friends and neighbours tested positive for COVID 19. Forty-six percent felt hopeless and lonely during the pandemic. Fifty three percent were not able to attend religious services and 32% were not at all satisfied in performing religious practices through an online platform. Forty six percent of elderly used social media during COVID-19 pandemic.: The physical and psychosocial wellbeing of the elderly were affected during the pandemic. The physical health of most of the elderly were satisfactory but while considering their diet, exercise and sleep during the pandemic, most of them faced problems. The psychological wellbeing of elderly was also affected adversely. Majority of the elderly experienced anxiety, fear of death and hopelessness during the pandemic. Public health services should be equipped to handle social disengagement and loneliness through various means of connecting older adults with others, such as through telephone or video conversations or online social media platforms. Society need to be prepared with hybrid care platforms such as tele health and in-person treatment.
Diurnal variation of peak expiratory flow rate in adolescents
Authors: Charles Spandana , Archana  , Padmavathy  , Priscilla  , Subhashini  
Published: February 2023

Lung functions exhibit a circadian rhythm. Peak Expiratory Flow Rate (PEFR) is an easily measured and reproducible parameter for measuring lung functions. Limited information is available on the circadian variations in lung functions in south Indian adolescents. Hence, this study was undertakento evaluate the diurnal variation of PEFR in adolescents.This longitudinal study was conducted among 30 adolescent girls in the age group of 18-19 years recruited from a hostel in Chirala, Andhra Pradesh. Smokers, pregnant women and subjects with history of tuberculosis were excluded from the study. PEFR was measured using the Mini — Wright s, peak flow meter, four times a day (5.30 – 6.00 am, 12.00-1.00 pm, 5.00-6.00 pm, 9-10.00pm) and the diurnal variation of lung function was calculated. The PEFR values at different time points were analyzed using analysis of variance. Statistical significance was taken at 5% level of significance. Amplitude % Mean and Standard deviation % Mean were used to estimate diurnal variation of PEFR. The mean PEFR recorded at 5.30 am, 12.00 noon, 5.00 pm and 9.00 pm were 340, 347, 349 and 348 respectively. The mean of amplitude % mean and standard deviation % mean obtained in this study were 8.42 ± 3.65and 3.87±1 respectively.C The results of this study indicate that PEFR in adolescents exhibits a definite circadian rhythm, it being lowest early in the morning, progressively rises till late afternoon following which there is a slight fall in the night.
Pengaruh Motivasi Kerja dan Kepuasan Kerja Terhadap Kinerja Karyawan Divisi Marketing CV Surya Gemilang Motor Rambipuji
Authors: Umami Rahma Rizki , Sutrisno Sutrisno , Wahjuni Sri 
Published: February 2023

Abstrak
Penelitian ini dilakukan dengan tujuan mengetahui, mendeskripsikan, dan menganalisis pengaruh motivasi kerja (X1) dan kepuasan kerja (X2) sebagai variabel yang berhubungan secara parsial dan simultan terhadap kinerja karyawan divisi marketing CV Surya Gemilang Motor Rambipuji. CV Surya Gemilang Motor Rambipuji merupakan perusahaan yang bergerak dibidang penjualan sepeda motor merek Honda. Rancangan penelitian ini menggunakan pendekatan paradigma kuantitatif dengan korelasi kausal asosiatif untuk mengetahui hubungan sebab akibat antara variabel bebas terhadap variabel terikatnya. Teknik analisis yang digunakan adalah analisis regresi linier berganda, dengan sampel sejumlah 41 responden. Hasil analisis menunjukkan 1) Motivasi kerja berpengaruh positif dan signifikan secara parsial terhadap kinerja karyawan divisi marketing CV Surya Gemilang Motor Rambipuji; 2) Kepuasan kerja berpengaruh positif dan signifikan secara parsial terhadap kinerja karyawan divisi marketing CV Surya Gemilang Motor Rambipuji; 3) Motivasi kerja dan kepuasan kerja berpengaruh positif dan signifikan secara simultan terhadap kinerja karyawan divisi marketing CV Surya Gemilang Motor Rambipuji.

Kata kunci : Motivasi Kerja, Kepuasan Kerja, Kinerja

Abstract
This research was conducted with the aim of knowing, describing, and analyzing the correlation of work motivation (X1) and job satisfaction (X2) as variables that are partially and simultaneously related to the performance of marketing employees at CV Surya Gemilang Motor Rambipuji. CV Surya Gemilang Motor Rambipuji is a company engaged in the sale of Honda motorcycles. The design of this study uses a quantitative paradigm approach with associative causal correlation to determine the causal relationship between the independent variables and the dependent variable. The analysis technique used is multiple linear regression analysis, with a sample of 41 respondents. The analysis showed 1) Work motivation had a positive and partially significant effect on the performance of marketing division employees at CV Surya Gemilang Motor Rambipuji; 2) Job satisfaction has a positive and partially significant effect on the performance of marketing division employees at CV Surya Gemilang Motor Rambipuji; 3) Work motivation and job satisfaction simultaneously have a significant and positive effect on the performance of marketing division employees at CV Surya Gemilang Motor Rambipuji.
Keywords : Work Motivation, Job Satisfaction, Employee Performance
Gerações em cena, filmar com mulheres Mbyá-Guarani
Authors: Pinheiro Sophia Ferreira 
Published: February 2023

Neste artigo faço a análise fílmica de dois cortes de um filme inacabado da cineasta indígena Mbyá-Guarani Patrícia Ferreira Pará Yxapy, o filme Pará Reté, sobre sua mãe, sua filha e sua avó. Mesmo inacabado, os cortes já foram exibidos em algumas mostras e festivais. Evocando o conceito de “filme-processo”, traço como o cotidiano e a intimidade são indissociáveis do processo de realização desse filme e apontam para uma das especificidades do cinema indígena feito por mulheres. Procuro demonstrar as diferentes circunstâncias, características do trabalho de Patrícia e de seu filme que acontece junto com a vida, de maneira a refletir sobre o processo de criação do seu filme a partir das relações dela com as personagens e do diálogo com a equipe do Vídeo nas Aldeias.
The impact of tectonic activity on carbonate density-flow deposition along two sectors of the Apulia Carbonate Platform
Authors: Saelen Gunnar , Spalluto Luigi , Grunnaleite Ivar , Sande Atle Jørgen Hestad , Jensen Niels Bo , Svendsen Per Olav Eide , Osso Gaetano , Paoli Nicola , Talbot Michael R. 
Published: February 2023

ABSTRACTGeneration of thick megabreccias along carbonate platforms apparently relies on the establishment of overpressured zones in the margin and upper slope deposits (particularly during relative sea-level lowstands), but the main triggering mechanism is thought to be seismic tremors. Here, we present a detailed sedimentological analysis of carbonate density-flow deposits south and north of the Mattinata Fault, a major strike-slip fault zone in the Gargano Promontory (Italy). The analysis shows that in the southern sector the deposits of Albian–Cenomanian age (Monte S. Angelo Formation) are made up predominantly of thick and amalgamated debrites (megabreccias), whereas some 25 km to the north they are composed predominantly of prograding high-density turbidites. Moreover, detailed analysis of Maastrichtian slope deposits (Monte Acuto Limestones) from the southern sector shows that they make up a N–S-prograding system of coalesced lobes composed of high-density turbidites and subordinate debrites. We infer that preconditional factors (e.g., platform progradation, tectonic oversteepening, and high pore pressures in the margin and upper-slope deposits) for triggering the density flows varied along strike of the platform, but the main controlling factors were the activity of the prominent strike-slip Mattinata Fault and the propagation of tremor energy to its near- and far-field regions: large earthquakes triggered thick (up to 40 m) and amalgamated Albian–Cenomanian debrites in proximity (south of) to the fault, whereas the subdued effect of the tremors triggered thinner debrites (5–10 m) and rock falls in the far-field region north of the fault. Moreover, predominantly high-density turbidite deposits were emplaced in the far-field region during lower-magnitude earthquakes. During the Maastrichtian the thick succession of high-density turbidites and scattered thick debrites south of and adjacent to the Mattinata Fault may record an overall quiescent period of the fault. The results are of relevance for understanding the spatiotemporal distribution of density-flow deposition along carbonate platforms in tectonically active regions—in particular with respect to the activity of large strike-slip faults.
Node-Block based Topology Control Algorithm for Mobile Optical Wireless Communication Networks
Authors: Gao Yan , Shang Tao , Qian Peiheng , Liu Yuanhao 
Published: February 2023

Abstract

Topology control is an efficient strategy to improve robustness and connectivity in networks. The mobility of nodes, the limited node degree and fragile links in optical wireless communication (OWC) networks make topology control a great challenge. In this paper, the node-block (NB) based topology control algorithm is proposed. Firstly, the proposed algorithm forms a stable tree structure, named node-block, using the predicted contact time between nodes as link weights. Secondly, quantized value based on GammaGamma channel model is used as the link weight to enable the establishment of multi-link connections between any two node-blocks. Finally, a connected graph is formed. The performance evaluation parameters, such as topological stability, algebraic connectivity and average node degree are discussed, and their expressions are given. Simulations are carried out, and a comparison with Minimum Spanning Tree (MST) algorithm is shown. The results indicate that our proposed topology control algorithm can ensure the connectivity and stability of the OWC networks. Meanwhile, the available node degree reserved is capable of large-scale networks.
KGCNA-CNN-BiLSTM：Knowledge graph and hybrid neural networks for drugs association prediction
Authors: Liu Shuang , Zhu Xiaomin 
Published: February 2023

Abstract

Drug association (DDIs) prediction is also called drug interaction prediction, which refers to the interactions between drug and drug that lead to unexpected side effects when two or more drugs are taken simultaneously or successively. Previous studies on DDIs prediction using methods such as molecular representation and network embedding were extremely complex, expensive and time-consuming, and were limited in acquiring rich neighborhood information about drug entities and their surroundings during the forecasting process. A drug linkage prediction method based on knowledge graphs and hybrid neural networks was proposed based on the deficiencies of the above methods. This method is mainly based on methods such as knowledge graphs, graph convolutional network, Convolutional-BiLSTM network and attention mechanisms to solve the limitations in acquiring rich neighborhood information about KG entities during the forecasting process. It transforms drug linkage prediction research into a link prediction problem and views drug relationships with known interactions as edges in the interaction graph. It can effectively discover interactions of unknown drugs; meanwhile, performance comparisons are performed with existing DDIs prediction methods. The results show that higher performance is achieved in terms of indicators such as ACC and F1 values, which validate the effectiveness of the model. Finally, future directions in this field are proposed based on an analysis and summary of challenges faced by current DDIs predictions.
Experience and Coping Strategies of Parents Regarding Home Care of Children After a Cancer Diagnosis in Rwanda
Authors: Musabeyesu Germaine , Ndayisenga Jerome , Niyoyita Jean Claude , Fitch Margaret I. , Nikuze Bellancille 
Published: February 2023

Abstract

Background

Home care for childhood cancer has recently gained acceptance in Sub-Saharan African countries including Rwanda. Home care may have positive implications for patients and their families, but it may also be burdensome to the caregivers. Little is known about the parents’ experience with home care in childhood cancer in Africa.

The purpose of the study

This study aimed to explore the experience and coping strategies of parents regarding home care of children diagnosed with cancer in Rwanda.

Methods

This study was qualitative using a phenomenological design. Ten participants (four key informant interviews and a focus group of six participants) participated who were parents of children diagnosed with cancer. Data were transcribed from audiotaped interviews, codes assigned to the content, and themes generated through thematic analysis using the Hycner version.

Results

The study revealed negative experiences regarding challenges, and individual coping strategies of parents regarding home care. Identified themes concerning experience were Feeling helpless, knowing that giving home care was laborious, feeling overwhelmed, feeling inadequate, and feeling uncertain. Identified themes concerning coping were Reliance on spirituality to cope, Balancing my emotions, Getting my mind off the current situation, Keeping life as normal as possible, Rebalancing life, and Finding and accepting support from family and friends.

Conclusion

Childhood cancer is emotionally, physically, and psychologically draining for parents. However, the challenges experienced enabled the parents to discover personal strategies to cope with the demands of home care.
Genetic Analysis and Prenatal Diagnosis of Acute Intermittent Porphyria Caused by Novel Classical Splicing Variant in the Insertion Region of 29-Residue Specific to Human HMBS Protein
Authors: Liang Lei , Meng Haixia , Wu Haotian , Zhao Jianrong 
Published: February 2023

Abstract
Background: Acute intermittent porphyria (AIP; OMIM#176000) is caused by mutations in the hydroxymethylbilane synthetase (HMBS) gene, which encodes the third enzyme of the heme biosynthesis pathway. A 29-residue insert (residues 296-324) exists at the interface between domains 1 and 3 of human HMBS (hHMBS), and its function remains unknown. In this study, on the HMBS gene of an AIP pregnant woman from China, we predicted the damage to 29-residue insert regions of a new classical splicing variant, and made prenatal diagnosis of the fetus of this pregnant woman.
Methods: We extracted peripheral blood from pregnant women and their husbands, as well as fetal amniotic fluid cells, and analyzed gene expression using prenatal whole exon sequencing and Sanger sequencing. RNA was extracted from peripheral blood of pregnant women and reverse transcribed into cDNA for alternative splicing verification. The protein structure of abnormal splicing caused by variant was predicted using I-TASSER and PyMOL software. Using AMBER14sb software, we simulated protein molecular dynamics.
Results: Pregnant women and her fetuses have a classical splicing variant in the HMBS gene, c.912+1G>C. The husband of the pregnant woman did not detect the variant. There are no reports of this variant in the literature. Results of peripheral blood transcription tests in pregnant women showed that c.912+1G>C retained the intron 13 and caused the exon 13 skipping. Homology modeling and molecular dynamics analysis revealed that the variant affected the HMBS protein's secondary structure, which led to functional differences.
Conclusion: A new classical splicing mutation with pathogenicity of HMBS gene c.912+1G>C was identified in this study, which expands the molecular heterogeneity of AIP and provides key information for genetic diagnosis.
Genome-wide Association Study Meta-analysis of Blood Pressure Traits and Hypertension in Sub-Saharan African Populations: An AWI-Gen Study
Authors: Singh Surina , Choudhury Ananyo , Hazelhurst Scott , Crowther Nigel , Boua Palwende , Sorgho Hermann , Agongo Godfred , Nonterah Engelbert , Micklesfield Lisa , Norris Shane , Kisiangani Isaac , Mohamed Shukri , Gomez-Olive Francesc , Tollman Stephen , Choma Solomon , Brandenburg Jean-Tristan , Ramsay Michele 
Published: February 2023

Abstract
Most hypertension-related genome-wide association studies (GWAS) focus on non-African populations, despite hypertension (a major risk factor for cardiovascular disease) being highly prevalent in Africa. The AWI-Gen study GWAS meta-analysis for blood pressure-related traits (systolic and diastolic blood pressure, pulse pressure, mean-arterial pressure and hypertension) from three sub-Saharan African geographic regions (N=10,775), identified two genome-wide significant signals (p<5E-08): systolic blood pressure near P2RY1 (rs77846204; intergenic variant, p=4.25E-08) and pulse pressure near Linc01256 (rs80141533; intergenic variant, p=4.25E-08). No genome-wide signals were detected for the AWI-Gen GWAS meta-analysis with previous African-ancestry GWASs (UK Biobank (African), Uganda Genome Resource). Suggestive signals (p<5E-06) were observed for all traits, with 29 displaying pleiotropic effects and several replicating known associations. Polygenic risk scores developed from studies on different ancestries had limited transferability, with multi-ancestry models providing better prediction. This study provides insights into the genetics and physiology of blood pressure variation in African populations.
Effects of fullerenol C60 on liver tissue in liver ischemia reperfusion injury in rats undergoing sevoflurane anesthesia Subtitle: Fullerenol C60 in liver ischemia reperfusion injury in rats
Authors: Yavuz Aydın , Tuna Ayca Tas , Ozdemir Cagrı , Mortas Tülay , Küçük Ayşegül , Kasapbaşı Esat , Arslan Mustafa , Kavutçu Mustafa , Kurtipek Omer 
Published: February 2023

Abstract
The aim of this study was to investigate the effects of fullerenol C60 on rat liver tissue in liver ischemia reperfusion injury (IRI) model undergoing sevoflurane anesthesia to evaluate the ability of nanoparticles to prevent hepatic complications. A total of 36 adult female Wistar Albino rats were divided into six groups each containing six as follows: sham group (Group S), the fullerenol C60 group (Group FC60), the ischemia-reperfusion group (Group IR), and the ischemia-reperfusion-sevoflurane group (Group IR-Sevo), ischemia-reperfusion-fullerenol C60 group (Group IR-FC60), ischemia-reperfusion-fullerenol C60-sevoflurane group (Group IR-FC60-Sevo). Fullerenol C60 100 mg/kg was administrated in Group IR-FC60 and IR-FC60-Sevo. In IR groups 2 hours of ischemia and 2 hours of reperfusion were performed. At the end of the reperfusion, liver tissues were removed for biochemical assays, and histopathological examinations. Hepatocyte degeneration, sinüsoidal dilatation, prenecrotic cell, MN celluler infiltration in the parenchyma were significantly higher in Group IR than all other groups. TBARS level was significantly higher in Group IR than other groups and the lowest TBARS level was in Group IR-FC60 than other groups except Group S and FC60. CAT and GST activities reduced in Groups IR than all other groups. Fullerenol C60 has protective effects against liver IR injury in rats under sevoflurane anesthesia. The use of fullerenol C60 could reduce the adverse effects of IRI and associated costs in liver transplantation surgery.