bluuebunny/crossref_metadata_2025_split huggingface dataset:
Streamlined quantitative BOLD for detecting visual stimulus-induced changes in oxygen extraction fraction in healthy participants: toward clinical application in human glioma
Authors: Arzanforoosh Fatemeh , Berman Avery J. L. , Smits Marion , Warnert Esther A. H. 
Published: August 2023

Abstract
Objective
Monitoring brain oxygenation is critical in brain tumors, as low oxygenation influences tumor growth, pathological angiogenesis, and treatment resistance. This study examined the ability of the streamlined quantitative (sq)BOLD MRI technique to detect oxygenation changes in healthy individuals, as well as its potential application in a clinical setting.

Methods
We used the asymmetric spin echo (ASE) technique with FLAIR preparation, along with model-based Bayesian inference to quantify the reversible transverse relaxation rate (R2') and oxygen extraction fraction (OEF) across the brain at baseline and during visual stimulation in eight healthy participants at 3T; and two patients with glioma at rest only.

Results
Comparing sqBOLD-derived parameters between baseline and visual stimulation revealed a decrease in OEF from 0.56 ± 0.09 at baseline to 0.54 ± 0.07 at the activated state (p = 0.04, paired t test) within a functional localizer-defined volume of interest, and a decline in R2' from 6.5 ± 1.3s−1 at baseline to 6.2 ± 1.4s−1 at the activated state (p = 0.006, paired t test) in the visual cortex.

Conclusion
The sqBOLD technique is sensitive enough to detect and quantify changes in oxygenation in the healthy brain and shows potential for integration into clinical settings to provide valuable information on oxygenation in glioma.
The impact of pre-processing and disease characteristics on reproducibility of T2-weighted MRI radiomics features
Authors: Dewi Dyah Ekashanti Octorina , Sunoqrot Mohammed R. S. , Nketiah Gabriel Addio , Sandsmark Elise , Giskeødegård Guro F. , Langørgen Sverre , Bertilsson Helena , Elschot Mattijs , Bathen Tone Frost 
Published: August 2023

AbstractPurposeTo evaluate the reproducibility of radiomics features derived via different pre-processing settings from paired T2-weighted imaging (T2WI) prostate lesions acquired within a short interval, to select the setting that yields the highest number of reproducible features, and to evaluate the impact of disease characteristics (i.e., clinical variables) on features reproducibility.Materials and methodsA dataset of 50 patients imaged using T2WI at 2 consecutive examinations was used. The dataset was pre-processed using 48 different settings. A total of 107 radiomics features were extracted from manual delineations of 74 lesions. The inter-scan reproducibility of each feature was measured using the intra-class correlation coefficient (ICC), with ICC values > 0.75 considered good. Statistical differences were assessed using Mann–WhitneyUand Kruskal–Wallis tests.ResultsThe pre-processing parameters strongly influenced the reproducibility of radiomics features of T2WI prostate lesions. The setting that yielded the highest number of features (25 features) with high reproducibility was the relative discretization with a fixed bin number of 64, no signal intensity normalization, and outlier filtering by excluding outliers. Disease characteristics did not significantly impact the reproducibility of radiomics features.ConclusionThe reproducibility of T2WI radiomics features was significantly influenced by pre-processing parameters, but not by disease characteristics. The selected pre-processing setting yielded 25 reproducible features.
Phosphorus Sources and Sheep Manure Fertilization for Soil Properties Enhancement and Sugar Beet Yield
Authors: Ali Ahmed Mahmoud , Mahdy Ahmed Yousef , Al-Sayed Hassan Mohamed , Bayomi Khaled Megahed 
Published: August 2023

AbstractInorganic fertilizers abundant used cause hazardous environmental effects and unsafe food. Contrarily, organic fertilizers are usually utilized as soil amendments and they boost crop yield quantity and quality. A field experiment was carried out to study the effect of some phosphorus (P) sources, such as rock phosphate (RP), superphosphate (SP), and sheep manure (SM), on some soil chemical properties, growth and yield in sugar beet plants. The field experiment was arranged in a completely randomized block design with three replicates for two growing seasons (2020/21and 2021/22). Results showed significant increases in yield and physiological parameters in all treatments. Co-applying of RP with SP caused a significant increase in the SOM, N, P, and K by 70.45, 31.52, 128.35, and 24.85% respectively compared to T1. All applications to the soil significantly increased the fresh weights of sugar beet roots were significantly increased by 24.71, 17.92 and 25.72% for T2, T3, and T4 respectively over the control. Also co-application of SM and SP (T3) lead to the highest sucrose content which increased by 5.09% than the control. Therefore, we concluded that integrated fertilizer management improves soil properties and yield so these results can be used to employ to reduce the detrimental consequences of using chemical fertilizers.
Land use changes in globally important cultural forests. The case of two traditionally managed forests for non-wood forest products (NWFPs) in China and Japan
Authors: Piras Francesco , Santoro Antonio 
Published: August 2023

AbstractNon-Wood Forest Products (NWFPs) still have a key role for the economy of many rural areas, for their sustainable development and for preserving traditional culture, landscape and biodiversity. Two sites inscribed in the Globally Important Agricultural Heritage Systems (GIAHS) Programme of the Food and Agriculture Organization (FAO) are based on traditional forest management devoted to shitake production: the Kunisaki Peninsula System (Japan) and the Qingyuan Forest-Mushroom Co-culture System (China). This study investigated the landscape structure of the two sites, assessing the land use changes in the last 10 years, and identifying the main drivers responsible of changes, through GIS-based spatial analyses of 2008 and 2019 land use maps. An accuracy assessment of the original databases has also been performed to validate the research findings. Results demonstrated that the maintenance of the traditional forest management has effectively contributed to the preservation of two different but both traditional landscape structures, but the methodology also allowed to identify some external pressures. In the Kunisaki peninsula the abandonment of agricultural surfaces (-4.3%) and consequent spread of grasslands (+ 63%) and forests (+ 1.3%) mainly affects areas at lower altitudes; in Qingyuan County deforestation (+ 280 ha/year), expansion of new cultivations (+ 250 ha/year) and urban sprawl (+ 67%), represent the main changes. Traditional forest practices represent effective examples of sustainable forest management, capable of providing high-quality NWFPs and ecosystem services to local communities, contributing to the preservation of local natural resources, of cultural heritage, and of biodiversity at the landscape scale.
Myco-fabricated ZnO nanoparticles ameliorate neurotoxicity in mice model of Alzheimer’s disease via acetylcholinesterase inhibition and oxidative stress reduction
Authors: Abd Elmonem Hanan A. , Morsi Reham M. , Mansour Doaa S. , El-Sayed El-Sayed R. 
Published: August 2023

AbstractAlzheimer’s disease (AD) is one of the primary health problems linked to the decrease of acetylcholine in cholinergic neurons and elevation in oxidative stress. Myco-fabrication of ZnO-NPs revealed excellent biological activities, including anti-inflammatory and acetylcholinesterase inhibitory potentials. This study aims to determine if two distinct doses of myco-fabricated ZnO-NPs have a positive impact on behavioral impairment and several biochemical markers associated with inflammation and oxidative stress in mice that have been treated by aluminum chloride (AlCl3) to induce AD. Sixty male mice were haphazardly separated into equally six groups. Group 1 was injected i.p. with 0.5 ml of deionized water daily during the experiment. Mice in group 2 received AlCl3 (50 mg/kg/day i.p.). Groups 3 and 4 were treated i.p. with 5 and 10 mg/kg/day of ZnO-NPs only, respectively. Groups 5 and 6 were given i.p. 5 and 10 mg/kg/day ZnO-NPs, respectively, add to 50 mg/kg/day AlCl3. Results showed that the AlCl3 caused an increase in the escape latency time and a reduction in the time spent in the target quadrant, indicating a decreased improvement in learning and memory. Moreover, acetylcholinesterase enzyme (AChE) activity and malondialdehyde (MDA), tumor necrosis factor-alpha (TNF-α), and interleukin 1β (IL-1β) levels were significantly increased, and the content of glutathione (GSH), activities of superoxide dismutase (SOD), catalase (CAT), alanine aminotransferase (ALT), and aspartate aminotransferase (AST), as well as levels of serotonin and dopamine, were decreased in brain tissues only in AlCl3 treated mice. However, treatment of mice with myco-fabrication of ZnO-NPs at doses of 5 or 10 mg/kg improves learning and memory function through ameliorate all the previous parameters in the AD mice group. The low dose of 5 mg/kg is more effective than a high dose of 10 mg/kg. In accordance with these findings, myco-fabricated ZnO-NPs could enhance memory and exhibit a protective influence against memory loss caused by AlCl3.
Writing Self-Efficacy in Postsecondary Students: a Scoping Review
Authors: Mitchell Kim M. , Zumbrunn Sharon , Berry Danielle N. , Demczuk Lisa 
Published: August 2023

Abstract In this review, we examine studies of writing self-efficacy conducted with postsecondary students published between 1984 and 2021. We aimed to inventory the methodological choices, writing contexts, and types of pedagogies explored in studies of writing self-efficacy with postsecondary students, and summarize the practical implications noted across the included studies. A total of 50 studies met eligibility criteria. All studies used quantitative methods, were conducted in English language settings, focused on undergraduate or graduate students, and included at least one writing self-efficacy measure. Across the 50 studies, the two variables most commonly appearing alongside writing self-efficacy were writing performance and writing apprehension. Many studies also assessed change in writing self-efficacy over time. Writing contexts and measures of writing self-efficacy varied across the included studies. Common practical implications noted across studies included students’ tendency to overinflate their writing self-efficacy, recognition of the developmental nature of writing ability, the importance of teacher attitudes and instructional climate, the influence of feedback on writing self-efficacy, and approaches to teaching and guiding writing. Based on this review, we see several directions for future research including a need for longitudinal studies, consideration of situated approaches, identification of diversity impacts, and attention to consistent use of strong multidimensional measures of writing self-efficacy.
Talc concentration effect on shelf life of acetaminophen tablets
Authors: Calvino Martina Maria , Cavallaro Giuseppe , Lazzara Giuseppe , Milioto Stefana 
Published: August 2023

AbstractExcipients in pharmaceutical formulations are inactive ingredient from the biological point of view, but they have a key role in the preparation, and they can alter the stability of the active principle. In this work, we prepared acetaminophen tablets with different amounts of talc as excipient and the thermal stability was deeply investigated by thermogravimetric studies. Isoconversional analysis by Kissinger–Akahira–Sunose method and “Master plot” analysis have been successfully employed to describe the kinetics of degradation under inert atmosphere, and the shelf lives have been calculated as a function of the talc content. The shelf-life values as well as the activation energy, which is the dominant factor, evidenced that the inorganic filler enhances the drug degradation to a certain extend and that the composition dependence has a peculiar trend reflecting the particle cluster formation at a critical concentration value. An effort of physico-chemical explanation for this behaviour is put forward by a simple geometrical model from the microparticle-size analysis to predict the critical talc concentration.
Thermal analysis and FTIR study of 4-n-hexadecyloxybenzoic acid (16OB)
Authors: Rudzki Arkadiusz , Chruściel Janusz , Zalewski Sławomir , Zając Wojciech 
Published: August 2023

AbstractWe have carried out phase polymorphism studies of 4-n-hexadecyloxybenzoic acid (16OB) in temperature range: from 10 to 150 °C with the use of Differrential Scanning Calorimeter, Thermal Microscopic Polarization and Transmitted Light Intensity. 16OB is a liquid crystal which has smectic C phase (SmC) and rich polymorphism in solid phase. Particularly interesting is one of the transitions in solid state possessing characteristic clear exothermic effect (during heating cycle) which is associated with the transition between the metastable and stable phases. Fourier transform infrared spectroscopy as a function of temperature was used to analyze changes in the nature of hydrogen bonds. The exact analysis of effects shows an existence of the metastable phases. The stable and metastable phases differ from each other in the structure made of hydrogen bonds.
Qualifizierung für die Transformation der Organisation nutzen – das Praxisbeispiel der IAV
Authors: Dahm Johanna , Dornoff Karolina , Handlbauer Stefanie , Lemke Anja , Heidelberger Maria , Kauffeld Simone 
Published: August 2023

ZusammenfassungDer Praxisbericht der Zeitschrift für Angewandte Organisationspsychologie „Gruppe. Interaktion. Organisation. (GIO)“ beschreibt die Transformationsqualifizierung des führenden Entwicklungsdienstleisters Ingenieurgesellschaft Auto und Verkehr (IAV GmbH). Durch die Transformation der Automobilindustrie, gesteuert durch Digitalisierung, Dekarbonisierung, Deglobalisierung und den demografischen Wandel, wurden bei der IAV Rollen identifiziert, die in Zukunft abgebaut oder vermehrt gebraucht werden. 1500 Mitarbeitende, vor allem Ingenieure, sind von der Transformation betroffen. Die Beschäftigungssicherung wird durch Umqualifizierungen strategisch geplant und, anders als in vorangegangenen Qualifizierungsprogrammen, basiert die Teilnahme auf Freiwilligkeit und ist nicht als top-down Prozess angelegt. Der erste Schritt ist die Bedarfsanalyse, der zweite Schritt ist die Kommunikation im Unternehmen, der dritte Schritt ist das Bewerbungs- und Auswahlverfahren, der vierte Schritt ist die Qualifizierungsmaßnahme, basierend auf einer Qualifizierungsmatrix, um einen individuellen Weiterbildungsplan zu erstellen und zuletzt findet im fünften Schritt der Funktionsrollenwechsel statt. Herausforderungen und Potenziale werden diskutiert und sollen in Form von Wissenstransfer von der Transformation betroffene Unternehmen unterstützen, Qualifizierung effektiv zu gestalten.
Solidification of Al12Si Melt Pool in Laser Powder Bed Fusion
Authors: Ghomashchi Reza , Nafisi Shahrooz 
Published: August 2023

AbstractAn understanding of the solidification characteristics of the melt pool during laser powder bed fusion, L-PBF, metal printing is essential to ensure the manufacture of sound parts. This is the main theme of this article where it is attempted to unlock the solidification black box through calculation/measurement of the main solidification parameters of cooling rate, growth rate, temperature gradient, and undercooling. The very small melt pool size and its rapid cooling hinder the application of conventional tools to extract such information. A knowledge of these parameters and their effect on the microstructure and morphology of constituent phases could help to better control the L-PBF process and indeed all the fusion-based additive manufacturing routes, to fabricate high-quality parts. Al12Si alloy solidification during the L-PBF fabrication route is examined to highlight the extreme changes in solidification parameters and their effect on the morphology and size of eutectic Si. This is because the morphology of Si controls the mechanical properties of the finished part. The Al–Si eutectic has a divorced architecture attributed to the difficulty associated with Si growth resulted from rapid solidification. The generation of a temperature gradient of about 7700 °C/mm resulted in cooling rates in the range of 1.1 × 106 °C/s and a growth rate of 140 mm/s. Such values were then used to predict the morphology of eutectic Si based on the traditional approach.
Consequences of undertreatment of hypothyroidism
Authors: Feldt-Rasmussen Ulla , Effraimidis Grigoris , Bliddal Sofie , Klose Marianne 
Published: August 2023

Abstract
Purpose
To provide an overview of consequences of undertreatment with levothyroxine (LT4) in the common non-communicable disease, hypothyroidism.

Methods
Narrative review of the literature.

Results
Hypothyroidism is globally very prevalent at all age groups and represents a non-communicable disease in which the risks and consequences are preventable. In children and adolescents, the most devastating consequences of undertreatment are poor growth and development. Lack of early treatment in congenital hypothyroidism can lead to permanent damage of brain function. In young to middle-aged adults, consequences are often overlooked, and treatment delayed by many years. The resulting consequences are also at this age group compromised brain and physical functioning but less severe and partly reversible with treatment. The undertreated condition often results in a higher risk of several secondary devastating diseases such as increased cardiovascular disease burden, obesity, hypertension, poor physical capacity, poor quality of life. In young women of fertile age the consequences of undertreatment with LT4 are subnormal fertility, recurrent pregnancy loss, preeclampsia, compromised fetal growth and neurocognitive development. There is a further risk of 30–50% of developing postpartum thyroiditis. In the elderly population care must be given to avoid confusing a slightly high serum TSH as result of physiological age adaptation with a requirement for LT4 treatment in a truly hypothyroid patient.

Conclusion
Undertreatment of the preventable non-communicable disease hypothyroidism requires more focus both from caretakers in the healthcare system, but also from the global political systems in order to prevent the personally devastating and socioeconomically challenging consequences.
Current understanding and future perspectives on the impact of changing NAFLD to MAFLD on global epidemiology and clinical outcomes
Authors: Vaz Karl , Clayton-Chubb Daniel , Majeed Ammar , Lubel John , Simmons David , Kemp William , Roberts Stuart K. 
Published: August 2023

AbstractIntroductionFor the first time in nearly half a century, fatty liver disease has undergone a change in name and definition, from the exclusive term, non-alcoholic fatty liver disease (NAFLD), to the inclusion-based, metabolic-associated fatty liver disease (MAFLD). This has led investigators across the globe to evaluate the impact the nomenclature change has had on the epidemiology and natural history of the disease.MethodsThis systematic review provides a comprehensive overview on how the shift in name and diagnostic criteria has influenced point prevalence in different geographic regions, as well as morbidity and mortality risk, whilst highlighting gaps in the literature that need to be addressed.ConclusionsMAFLD prevalence is higher than NAFLD prevalence, carries a higher risk of overall mortality, with greater granularity in risk-stratification amongst MAFLD subtypes.Graphical abstract
The Effects of Using Psychotherapeutic e-Mental Health Interventions on Men’s Depression and Anxiety: Systematic Review and Meta-Analysis
Authors: Opozda Melissa J. , Oxlad Melissa , Turnbull Deborah , Gupta Himanshu , Vincent Andrew D. , Ziesing Samuel , Nankivell Murray , Wittert Gary 
Published: August 2023

AbstractWhile psychotherapeutic e-mental health interventions may circumvent barriers that many men face in accessing mental health care, the effects of men using these interventions have not been evaluated. We aimed to synthesise the characteristics of psychotherapeutic e-mental health interventions for depression or anxiety that have been trialled and evaluated in men, and synthesise and meta-analyse the effects of these interventions on men’s depression and anxiety, including examining influences of participant, intervention, and study characteristics on outcomes. Seven papers (N = 552 participant men) identified from systematic literature searches met inclusion criteria. A total 177 studies were excluded because although they met all other inclusion criteria, they did not present analysable data on participant men. The seven included interventions varied in content, length, and format; only one intervention was gender sensitive, having been designed specifically for men. All three randomised controlled trials detected no post-trial difference in men’s depression symptoms between intervention and control participants. All four treatment studies presenting pre-post data reported post-intervention improvements in depression or social anxiety symptoms; this was supported by our meta-analysis of two studies, which found a medium-sized, positive effect of depression treatment interventions on depression symptoms in pre-post data (g = 0.64, p < 0.005). Further meta-analyses could not be conducted due to data limitations. Psychotherapeutic e-mental health treatment interventions result in pre- to post-intervention improvements in men’s depression symptoms. There is urgent need for consideration of gender and sex in the development, evaluation, and dissemination of e-mental health interventions for men, and for further information on their effects.
A preliminary study on the relationship between cultural identification, racial discrimination, and well-being of Chinese Malaysians Young adults
Authors: Ting Rachel Sing-Kiat , Lim Xin-Jean , Lim Joy Yung-Re , Choo Jia-Yee 
Published: August 2023

AbstractIt was well documented that racial minorities struggle with discrimination that jeopardizes their mental well-being. However, the interaction between cultural identification (CI) and mother tongue (MT) on perceived discrimination among minority communities was unclear. This study adopted a cross-sectional survey to investigate how different Chinese in Malaysia (CIM) groups experience in-group versus out-group discrimination based on their MT, and its impact on well-being. We hypothesized that (1) different CIM-MT groups would differ in their in-group discriminations; (2) there would be a pathway from CI to discrimination and to mental well-being; (3) MT would have a moderation effect on the pathway. A standardized online survey measuring CI (national vs. ethnic), perceived discrimination (in-group vs. out-group), and mental well-being (life satisfaction vs. mental distress) was administered to CIM college students. Analysis using ANCOVA and PLS-SEM (N = 288) showed that the English-MT group reported higher in-group discrimination than the Chinese-MT group. Moreover, the PLS-SEM analysis showed that ethnic identity, not national identity, displayed a significant negative association with in-group discrimination, which then significantly predicted mental distress in general. Furthermore, MT was a significant moderator between national identity and out-group discrimination. The findings confirmed that MT could predispose CIM to different exposure of racial dynamics and contexts. In lieu of the detrimental effect of both forms of racial discrimination, we advocate for culturally responsive mental health services for ethnic minorities around the world.