bluuebunny/crossref_metadata_2025_split huggingface dataset:
Waxholm Space atlas of the rat brain: A 3D atlas supporting data analysis and integration
Authors: Kleven Heidi , Bjerke Ingvild , Clascá Francisco , Groenewegen Hendrik , Bjaalie Jan , Leergaard Trygve 
Published: February 2023

Abstract
Volumetric brain atlases are increasingly used to integrate and analyse diverse experimental neuroscience data acquired from animal models, but until recently a publicly available digital atlas with complete coverage of the rat brain has been missing. Here we present the new Waxholm Space rat brain atlas, a comprehensive open-access volumetric atlas resource. This full brain atlas features annotations of 222 structures, of which 112 are new and 57 revised compared to previous versions. It maps in detail the cerebral cortex, hippocampal region, striatopallidal areas, midbrain dopaminergic system, thalamic cell groups, the auditory system and main fibre tracts. We document the criteria underlying the new annotations and demonstrate how the atlas and related tools and workflows can be used by neuroscientists to support interpretation, integration, analysis, and dissemination of experimental rat brain data.
Epidemiological and clinical features of SARS-CoV-2 Omicron variant infection in China: A retrospective study
Authors: Weng Zhangyan , Zheng Yijuan , Zheng Minghui , Chen Wenhuang , He Haoyi , Ye Xiaoyi , Zheng Youxian , Xie Jianfeng , Zheng Kuicheng , Zhang Jiming , Zhuang Xibin , Su Zhijun , Zhou Yongjun , Yu Xueping , Zhang Huatang 
Published: February 2023

Abstract
Background: A rapid increase in incidence of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant occurred in Quanzhou City, Fujian Province, China, in March 2022. This study investigated the epidemiological and clinical features of SARS-CoV-2 Omicron variant (BA.2)-infected patients.
Methods: Epidemiological and clinical data of SARS-CoV-2 Omicron variant infected patients admitted to three designated hospitals in Quanzhou were collected and analyzed.
Results: Overall, 2,541 patients infected with BA.2, comprising 1,060 asymptomatic, 1,287 mild, and 194 moderate infections, were enrolled in this study. The percentage of moderate infections was higher in those aged ≥60 than in those aged <18 and 18-59. The median hospitalization duration was 17 (14-20) days. Among the 2,541 patients, 43.52% had a clear history of close contact. The vaccination rate for coronavirus disease was 87.92%, and the percentage of asymptomatic infections was higher in vaccinated patients than in unvaccinated patients. Moreover, 10.82% with underlying diseases, such as hypertension (5.94%) and diabetes mellitus (3.12%), had a higher percentage of moderate infections than those without underlying diseases. The three most common clinical manifestations among the patients were fever (27.47%), dry cough (25.19%), and sore throat (15.31%). The albumin-to-globulin (A/G) ratio and lymphocyte count decreased in the cases of mild and moderate infections, while procalcitonin, erythrocyte sedimentation rate, interleukin-6, D-dimer, and C4 levels increased. The pulmonary computed tomography findings for moderate infections were generally patchy and ground-glass opacities.
Conclusions: Advanced age, non-vaccination, and underlying comorbid disease are high-risk factors for disease progression in Omicron variant-infected patients, while dynamic monitoring of blood routine parameters, A/G ratio, and inflammatory indicators facilitate the prediction of disease progression.
Structural evidence for direct connectivity between the human precuneus and temporal pole via the fifth subcomponent of the Cingulum.
Authors: Skandalakis Georgios P. , Komaitis Spyridon , Neromyliotis Eleftherios , Drossos Evangelos , Dimopoulos Dimitrios , Hadjipanayis Constantinos G. , Kongkham Paul N. , Zadeh Gelareh , Stranjalis George , Koutsarnakis Christos , Kalyvas Aristotelis 
Published: February 2023

Abstract

Neuro-imaging studies demonstrate simultaneous activation of the human precuneus and temporal pole, both in resting-state conditions and during a diverse array of higher-order functions. Despite remarkable advances in neuroscience research, the precise underlying structural connectivity remains unclear. Here, we investigate the connectivity of the precuneus and temporal pole through fiber micro-dissections in human hemispheres. We show the direct axonal connectivity between the posterior precuneus area POS2 and the areas 35 and TI of the temporal pole via the fifth subcomponent of the cingulum. This finding enhances the neuroanatomical knowledge regarding the connectivity of the posteromedial cortices, facilitates the detailed anatomo-functional integration in normal and pathological brain function, and suggests an axonal connectivity unique within the human brain supporting the differences in neural networks between species.
Chlorophyll-a Concentration in the Salto Grande Reservoir (Americana, Brazil) Estimated by Satellite Images
Authors: Rodrigues Vivian Fernanda Wiesenhutter , Shimabukuro Rafael Kenji Koike , Machado Ronalton Evandro 
Published: February 2023

Abstract
Humankind has a deep relationship with water, which is essential for life, since it is used to meet different human needs; however, human interactions and activities have degraded the quality of water bodies. In this context, monitoring water bodies becomes an essential tool to understand their spatial and temporal variability, as well as to help in decision-making and water resource management. Traditional monitoring, based on sample collection and laboratory analysis, can be considered a costly, one-off process that fails to present the characteristics of the entire water body. Remote sensing techniques can be used complementarily to traditional monitoring, allowing to observe the entire water body while presenting lower costs and short execution time. This study used remote sensing techniques to evaluate the trophic state of the Salto Grande reservoir using Chlorophyll-a (Chl-a) concentration as an analysis parameter. Located in the municipality of Americana, São Paulo, Brazil, the Salto Grande reservoir is situated on the Atibaia River, near its mouth, amidst a highly industrialized region with expressive monoculture. This reservoir has a history of degradation over time. Chl-a was estimated based on images from the MSI sensor present on the Sentinel-2 satellite, which underwent atmospheric correction by Sen2Cor software. Four algorithms using spectral band ratios were tested, with both linear and nonlinear adjustments. The values obtained were compared with data from analyses performed by CETESB, with close dates, at the study site and available to the public. The adjusted algorithms presented a correlation above 0.8, while the best adjustments for each algorithm showed a correlation greater than 0.9 and an error rate below 10% and 8 µg/L. Mishra and Mishra’s (2012) NDCI algorithm had the best applicability as it returned only positive values, in contrast to some algorithms, which returned negative Chl-a values. With the resulting values from the selected algorithm, the modified Carlson Trophic State Index was applied, and a high eutrophication index was observed in the reservoir.
The effects of inspiratory muscle training with pulmonary rehabilitation on NSCLC patients during radiation therapy: A pilot clinical study
Authors: Do Junghwa , Lee Seung Hak , Kim Sang Ah , Gelvosa Ma. Nessa , Kim A Hyun , Jeon Jae Yong Jeon 
Published: February 2023

Abstract
Purpose: The effects of inspiratory muscle training (IMT) with pulmonary rehabilitation (PR) on patients with non-small cell lung cancer (NSCLC) receiving radiotherapy (RT) have not been reported. This pilot study aimed to determine the effectiveness of IMT with PR on respiratory muscles and exercise capacity of NSCLC patients receiving RT.
Methods: We retrospectively analyzed 20 patients who underwent RT for NSCLC. The rehabilitation included IMT, stretching, strengthening, and aerobic exercises three times a week for 4 weeks with concurrent RT. IMT training lasted 10 min, consisting of one cycle of 30 breaths using the Powerbreathe KH1 device (POWERbreathe KH1, HaB International Ltd, Southam, UK) in the hospital by a physical therapist. Patients underwent two IMT sessions at home daily at an intensity of approximately 30–50% of the participant’s maximum inspiratory muscle pressure (MIP) using the Threshold IMT tool. We analyzed results from the respiratory muscle strength test, pulmonary function test, 6-min walk test (6MWT), cardiopulmonary function test, cycle endurance test (CET), Inbody test, grip measurement, knee extensor/flexor strength measurement, Cancer Core Quality of Life Questionnaire (EORTCQ-C30), and NSCLC 13 (EORTC-LC13).
Results: There were no adverse events during evaluation and IMT with PR. MIP (60.1±25.1 vs 72.5±31.9, p=0.005), 6MWT (439.2±97.1 vs 60.7±97.8, p=0.002), CET (181.39±193.12 vs 123.6±87.6, p=0.001), knee extensor (14.4±5.3 vs 17.4±5, p=0.012), and knee flexor (14.0±5.2 vs 16.9±5.5, p=0.004) significantly improved after IMT with PR.
Conclusion: IMT with PR appears effective on respiratory muscles and exercise capacity without adverse events in NSCLC patients who underwent RT.
Lower heart rate variability, an index of worse autonomic function, is associated with worse beta cell response to a glycemic load in vivo– The Maastricht Study
Authors: Rinaldi Elisabetta , Heide Frank CT , Bonora Enzo , Trombetta Maddalena , Zusi Chiara , Kroon Abraham A , Schram Miranda T , Kallen Carla JH , Wesselius Anke , Bonadonna Riccardo , Mari Andrea , Schalkwijk Casper G , Greevenbroek Marleen MJ , Stehouwer Coen DA 
Published: February 2023

Abstract
Objective
We investigated, using population-based data, whether worse autonomic function, estimated from lower 24-hour heart rate variability (HRV), was associated with beta cell function, assessed from beta cell response during an oral glucose tolerance test (OGTT).
Research design and Methods
We used cross-sectional data from The Maastricht Study, a population-based cohort study (N=2,007; age, mean ± SD:60 ± 8 years; 52% men; and 24% with type 2 diabetes). We used linear regression analyses with adjustment for potential confounders (demographic, cardiovascular, and lifestyle factors) to study the associations of time- and frequency-domain HRV (composite scores) with overall beta cell response (estimated from a composite score calculated from: C-peptidogenic index, overall insulin secretion, beta cell glucose sensitivity, beta cell potentiation factor, and beta cell rate sensitivity). In addition, we tested for interaction by sex and glucose metabolism status.
Results
After full adjustment, lower time- and frequency-domain HRV was significantly associated with lower overall beta cell response composite score (standardized beta, -0.055 [-0.098; -0.011] and -0.051 [-0.095; -0.007], respectively). These associations were not modified by sex and there was no consistent pattern of interaction by glucose metabolism status.
Conclusion
The present study found that worse autonomic function, estimated from lower HRV, was associated with worse beta cell function, estimated from a composite score in a population-based sample which covered the entire spectrum of glucose metabolism. Hence, autonomic dysfunction may contribute to beta cell dysfunction and, ultimately, to the alteration of glucose metabolism status from normal glucose metabolism to prediabetes and type 2 diabetes.
Regenerated silk fibroin based on small aperture scaffolds and marginal sealing hydrogel for osteochondral defect repair
Authors: Luo Yinyue , Xiao Menglin , Almaqrami Bushra Sufyan , Kang Hong , Shao Zhengzhong , Chen Xin , Zhang Ying 
Published: February 2023

Abstract
Background
Osteochondral defects pose an enormous challenge with no entirely satisfactory repair strategy to date. In particular, the lateral integration of neocartilage into surrounding native cartilage is a difficult and inadequately addressed problem that determines the success of tissue repair. Herein, a novel design of an integral regenerated silk fibroin (RSF)-based three-layer scaffold combined with a self-setting RSF sealant for osteochondral repair is reported.
Methods
Regenerated silk fibroin (RSF) based on small aperture scaffolds was prepared with n-butanol innovatively. Then, the rabbit knee chondrocytes and bone mesenchymal stem cells (BMSCs) were cultured on RSF scaffolds, and after induction of chondrogenic differentiation, cell-scaffold complexes strengthened by RSF hydrogel were prepared for in vivo experiments.
Results
A porous small aperture scaffold and RSF sealant exhibiting biocompatibility and good adhesive properties were developed and confirmed to promote chondrocyte migration and differentiation. Importantly, small aperture scaffolds had a larger surface area accommodating more cells and contributed to higher intercellular communication and elastic modulus. An RSF hydrogel was conducted as a medium between the scaffolds and the native tissues and then guided new chondrocytes to crawl towards and replace the degraded materials from the surrounding cartilage. Thus, osteochondral repair and superior lateral integration were achieved in vivo with this composite.
Conclusions
Our results suggest that a new approach of marginal sealing around the RSF cartilage layer of small aperture scaffolds exhibits preeminent repair results as compared to other scaffolds, confirming the ability of this novel graft to facilitate simultaneous regeneration of cartilage-subchondral bone.
Demographic and clinical characteristics associated with anxiety and depressive symptom outcomes in users of a digital mental health intervention incorporating a relational agent
Authors: Chiauzzi Emil , Williams Andre , Mariano Timothy Y. , Pajarito Sarah , Robinson Athena , Kirvin-Quamme Andrew , Forman-Hoffman Valerie 
Published: February 2023

Abstract

Background
Digital mental health interventions (DMHIs) may reduce treatment access issues for those experiencing depressive and/or anxiety symptoms. DMHIs that incorporate relational agents may offer unique ways to engage and respond to users and to potentially help reduce provider burden. This study tested WB-LIFE, a DMHI that employs Woebot, a relational agent that delivers evidence-based psychotherapies, among those with baseline clinical levels of depressive or anxiety symptoms. Self-reported depressive and anxiety symptom changes between baseline and end of 8-week intervention, as well as the association between demographic and clinical characteristics and each outcome, were measured
Methods
This exploratory, single-arm, 8-week study of 256 adults yielded non-mutually exclusive subsamples with either clinical levels of depressive or anxiety symptoms at baseline. Week 8 Patient Health Questionnaire-8 (PHQ-8) changes were measured in the depressive subsample (PHQ-8≥10). Week 8 Generalized Anxiety Disorder-7 (GAD-7) changes were measured in the anxiety subsample(GAD-7≥10). Demographic and clinical characteristics were examined in association with symptom changes via bivariate and multiple regression models adjusted for WB-LIFE utilization. Characteristics included age, sex at birth, race/ethnicity, marital status, education, sexual orientation, employment status, health insurance, baseline levels of depressive and anxiety symptoms, and concurrent psychotherapeutic or psychotropic medication treatments during the study.
Results
Both the depressive and anxiety subsamples were predominantly female, educated, non-Hispanic white, and averaged 38 and 37 years of age, respectively. The depressive subsample had significant reductions in depressive symptoms at Week 8 (mean change= - 7.28, p<0.01); the anxiety subsample had significant reductions in anxiety symptoms at Week 8 (mean change= -7.45, p<0.01). No significant associations were found between sex at birth, age, employment status, educational background and Week 8 symptom changes. Significant associations between depressive and anxiety symptom outcomes and sexual orientation, marital status, concurrent mental health treatment, and baseline symptom severity were found.
Conclusions
The present study suggests early promise for WB-LIFE as an intervention for depression and/or anxiety symptoms. Although exploratory in nature, this study revealed potential user characteristics associated with outcomes that can be investigated in future studies.
Trial Registration
This study was retrospectively registered on ClinicalTrials.gov (#NCT05672745) on 05/01/2023.
Comparison between the mesenteric fixation method(MEFIX) and conventional methods at preventing the occurrence of Petersen’s hernia: A study protocol for a multicenter randomized controlled trial
Authors: Park Jae Kyun , Kim Dae Hwan , Jeon Tae Yong , Jeong Sang Ho , Kim Tae Han , Min Jae Seok , Kim Rock Bum , Lee Young Joon , Park Ji Ho , Son Young Gil , Yoon Ki Young , Seo Kyung Won , Kim Ki Hyun , Kim Yoon Hong , Chae Hyun Dong , Hwang Sun Hui , Lee Si Hak , Chung Jae Hun , Kim Hyoung Il , Park Dong Jin , Kim Kwang Hee , Seo Sang Hyuk , Oh Sung Jin , Lee Woo Yong , Choi Chang In 
Published: February 2023

Abstract
Background

Petersen's hernia, which occurs after minimally invasive surgery for gastric cancer, can be reduced by defect closure. This study aimed to demonstrate the incidence of bowel obstruction above Clavien–Dindo classification grade III due to Petersen's hernia between the mesenteric fixation method(MEFIX) and the conventional methods during the 5-year follow-up period after laparoscopic gastric cancer surgery.

Methods

This prospective, single-blind, non-inferiority randomized controlled trial and multicenter study was conducted at hospitals in Korea. Patients with histologically diagnosed gastric cancer of clinical stage I, II, or III who underwent Roux-en-Y or B- II gastrojejunostomy anastomosis after laparoscopic gastrectomy were enrolled in this study. Patients who met the inclusion criteria were randomly assigned to two groups: a CLOSURE group that underwent Petersen's defect closure method and a MEFIX group that underwent the mesenteric fixation method.

Discussion

This trial is expected to provide high-level evidence showing that the MEFIX method can quickly and easily close Petersen's defect and reduce postoperative complications compared to the conventional method. It is also expected to be applicable not only after gastric cancer surgery but also after bariatric surgery.

Trial registration

The MEFIX study protocol was registered in htrp://register.clinicaltrials.gov as NCT05105360 (registration date: November 3, 2021)
Unconditional Cash and Family Investments in Infants: Evidence from a Large-Scale Cash Transfer Experiment in the U.S.
Authors: Gennetian Lisa , Duncan Greg , Noble Kimberly , Fox Nathan , Yoshikawa Hirokazu , Halpern-Meekin Sarah , Magnuson Katherine 
Published: February 2023

Abstract

Worldwide millions of families with children residing with low or precarious income receive some form of unconditional cash income. Nevertheless economists have limited causal evidence on how families receiving unconditional income would spend those funds. We examine financial and time investments in infants among families living in poverty from a large-scale, multi-site randomized controlled study of monthly unconditional cash. We find increased spending on child-specific goods and mothers’ early-learning activities with their infants. The marginal propensity to consume child-focused items from the cash transfer exceeded that from other income, consistent with the behavioral cues in the design. We find no statistically detectable offsets in household earnings or impacts on pre-registered outcomes related to expenditures, labor supply, childcare or subjective well-being.
JEL: D13, H31, I30, J13, J18, J22
Exam Room Timetabling Using MIP and SMAC
Authors: Agrawal Virupaksh 
Published: February 2023

Abstract

At the end of every academic session, institutions around the world need to schedule final examinations for students. This entails allocating sufficient space for each course that requires it in a manner that minimizes scheduling conflicts for students taking multiple courses. The primary goal is to minimize cost associated with administering these exams-driven by the cost of invigilation staff needed. This paper explores the implementation of an MIP solver (CPLEX) in addition to Sequential Model-based Algorithm Configuration (SMAC) that exhibits potential to replace the current methods-consisting of heuristics and greedy algorithms. The approach produced promising results for both schedule optimality and faster generation, particularly on larger instances. However, due to computational power constraints, there remains a need for further testing on realistically-sized instances.
Shifting the narrative from living at risk to living with risk: Validating and pilot-testing a clinical decision support tool: a mixed methods study
Authors: MacLeod Heather , Veillette Nathalie , Klein Jennifer , Delli-Colli Nathalie , Egan Mary , Giroux Dominique , Kergoat Marie-Jeanne , Gingrich Shaen , Provencher Véronique 
Published: February 2023

Abstract
Background
When there are safety concerns, healthcare professionals (HCPs) tend to overprotect older adults and may disregard their wishes to return or remain at home. A paradigm shift is needed for HCPs to move from labelling older adults as living at risk to helping them live with risk. The Living with Risk: Decision Support Tool (LwR:DST) was developed to support older adults and HCPs with difficult decision-making regarding living with risk. The study objectives were to: 1) validate, and 2) pilot-test the LwR:DST in hospital and community settings.
Methods
The study was conducted across Canada during the pandemic. The LwR:DST’s content was validated with quantitative and qualitative data by: 1) 71 HCPs from hospital and community settings using the Delphi method, and 2) 17 older adults and caregivers using focus groups. HCPs provided feedback on the LwR:DST’s content, format and instruction manual while older adults provided feedback on the LwR:DST’s communication step. The revised LwR:DST was pilot-tested by 14 HCPs in one hospital and one community setting, and 17 older adults and caregivers described their experience of HCPs using this approach with them. Descriptive and thematic analysis were performed.
Results
The LwR:DST underwent two iterations incorporating qualitative and quantitative data provided by HCPs, older adults and caregivers. The quantitative Delphi method data validated the content and the process of the LwR:DST, while the qualitative data provided practical improvements. The pilot-testing results suggest that using the LwR:DST broadens HCPs’ clinical thinking, structures their decision-making, improves their communication and increases their competence and comfort with risk assessment and management. Our findings also suggest that the LwR:DST improves older adults’ healthcare experience by feeling heard, understood and involved.
Conclusions
This revised LwR:DST should help HCPs systematically identify frail older adults’ risks when they remain at or return home and find acceptable ways to mitigate these risks. The LwR:DST induces a paradigm shift by acknowledging that risks are inherent in everyday living and that risk-taking has positive and negative consequences. The challenges involved in integrating the LwR:DST into practice, i.e., when, how and with whom to use it, will be addressed in future research.