bluuebunny/crossref_metadata_2025_split huggingface dataset:
Management accounting and control systems as devices for public value creation in higher education
Authors: Salemans Luc , Budding Tjerk 
Published: April 2023

AbstractThis paper investigates how management accounting and control systems (operationalized by using Simons’ levers of control framework) can be used as devices to support public value creation and as such it contributes to the literature on public value accounting. Using a mixed methods case study approach, including documentary analysis and semi‐structured interviews, we found diverging uses of control systems in the Dutch university of applied sciences we investigated. Although belief and interactive control systems are used intensively for strategy change and implementation, diagnostic controls were used mainly at the decentral level and seen as devices to make sure that operational and financial boundaries were not crossed. Therefore, belief and interactive control systems lay the foundation for the implementation of a new strategy, in which concepts of public value play a large role, using diagnostic controls to constrain actions at the operational level. We also found that although the institution wanted to have interaction with the external stakeholders, in daily practice, this takes place only at the phase of strategy formulation, but not in the phase of intermediate strategy evaluation.
Climate change impacts on Mediterranean vegetation are amplified at low altitudes
Authors: Saatkamp Arne , Argagnon Olivier , Noble Virgile , Finocchiaro Marie , Meineri Eric 
Published: April 2023

AbstractAimIn the face of ongoing climate warming, we wanted to quantify impacts on vegetation at one of the major climatic and biogeographical boundaries of Europe, the limit between the Mediterranean and Eurosiberian biogeographical regions. We analyse temperature and moisture requirements of plants along altitudinal gradients at regional scale in the period 1980–2020 and we explore if changes coincide with observed changes in the same regions in terms of measured climatic data.LocationSouthern France.Time period1980–2020.TaxaVascular plants.MethodsWe calculated shifts in plants’ temperature and moisture requirements for a large floristic database from south‐eastern France (SIMETHIS) during the period 1980–2020 along altitudinal gradients by using ecological indicator values (EIV). Additionally, we analysed standardized weather station data from the same area and period, to investigate whether floristic changes are synchronized with climate changes.ResultsVegetation data suggest a linear increase in temperature requirements of plant communities from 1980 to 2020 with a greater change at low altitudes. Upward shifts in temperature requirements coincided with observed climate change although warming did not show a general trend towards greater increases at low altitudes. Data on vegetation and climate suggest an upward shift of respectively 150 and 300 m for the boundary between Mediterranean and temperate belts. Moisture requirements of vegetation indicate an increase of the frequency of dry adapted species at low altitudes but an increase towards higher moisture requirements at high altitudes. Comparing vegetation responses with climate data suggests that responses are faster at low altitudes.Main conclusionsOur analyses show that strong general changes in vegetation are underway and highlight faster responses of vegetation to warming in low altitudes compared to high altitudes and demonstrate the need for reliable data on vegetation and climate changes, especially on water balance.
Systematic review and estimated cost‐efficacy of biologics compared with narrowband ultraviolet B light for the treatment of moderate to severe psoriasis and atopic dermatitis
Authors: McCoy Tatiana , Natarelli Nicole , Pan Adrianne , Shakhbazova Anastasia , Sivamani Raja K. , Chambers Cindy J. 
Published: April 2023

AbstractPsoriasis and atopic dermatitis are chronic inflammatory skin conditions, each affecting about 2–3% of the United States adult population. Phototherapy, such as narrowband ultraviolet‐B (NB‐UVB) therapy have been employed for the treatment of both psoriasis and atopic dermatitis for decades. More recently, systemic biologics have been approved by the Food and Drug Administration (FDA), representing a great advancement in dermatology. No comprehensive study to date has compared the cost efficacy of phototherapy compared to FDA‐approved biologics for the treatment of psoriasis and atopic dermatitis. We pursued a systematic review of the literature for studies assessing efficacy of NB‐UVB or biologics with endpoints including the Psoriasis Area and Severity Index (PASI) and the Eczema Area and Severity Index (EASI). Thirty‐four studies including 55 treatment regimens and 5,123 patients were included in the analysis. Phototherapy costs were estimated with Medicare fee schedules for phototherapy‐related current procedural terminology code (CPT), and biologic costs were estimated with wholesale acquisition cost (WAC). Total costs to achieve PASI 75 or EASI 75 in each study were standardized to a single month, the “adjusted cost,” and exploited to a year, the “effective yearly cost,” allowing direct cost‐efficacy comparison despite different durations of treatment described in studies. The psoriasis analysis found NB‐UVB to be the most cost‐effective therapy, with an adjusted monthly cost of $1714.00 per PASI 75. Infliximab was the least expensive biologic, with an adjusted monthly cost of $2076.00 to $2502.00 per PASI 75. For atopic dermatitis, no NB‐UVB studies utilized EASI 75 as their outcome measure, hindering the ability to directly compare cost effectiveness for the treatment of atopic dermatitis. However, all NB‐UVB studies depicted a reduced treatment cost per treatment period compared to studies assessing biologics, although this comparison does not account for efficacy. The results depict NB‐UVB to be the most cost effective for the treatment of psoriasis and the least expensive per treatment period for the treatment of atopic dermatitis. However, certain factors need to be taken into account. Biologics may be more effective for more severe disease, do not require multiple weekly clinic visits, and the ease for patient compliance may lead some to favor biologic therapy. This study is necessary to allow physicians, patients, and health systems to make informed decisions regarding cost‐efficacy for a variety of treatment options.
Effects of different processing methods on the antioxidant and antimicrobial properties of honey: a review
Authors: Faraz Ayesha , Fernando Wmad Binosha , Williams Mark , Jayasena Vijay 
Published: April 2023

SummaryThe use of honey as a food and a medicine date back to prehistoric times. Uses include treating wounds, cuts, burns, coughs and colds. The antioxidant and antibacterial properties of honey are believed to be responsible for its medicinal properties. Honey is usually processed before consumption. Honey is subjected to thermal processing, which adversely affects its quality. Honey can also be processed by non‐thermal methods, such as high‐pressure processing, ultrasonication, irradiation and microwave processing. In this review, the effects of thermal and non‐thermal processing methods on the antioxidant and antibacterial properties of honey have been summarised. Thermal processing and microwave processing of honey adversely affect the antioxidant and antimicrobial activities of honey. In contrast to other non‐thermal processing methods, high‐pressure processing and gamma irradiation have no effect on the antibacterial activity or antioxidant properties of honey. Ultrasound processing increases antioxidant activity of honey.
Experiential knowledge: From philosophical debate to health care practice?
Authors: Dings Roy 
Published: April 2023

AbstractDespite experience‐based expertise being increasingly common in health care, what experiential knowledge consists of remains a topic for debate. Here I propose a philosophical approach to clarify experiential knowledge, drawing on an analogous debate in philosophy of mind, which similarly targets the intuition that experience may generate unique knowledge. I outline the philosophical debate and explicate some relevant ideas for health care, so as to (a) evaluate whether and to what extent this analogous debate is helpful, and (b) supplement existing ideas on experiential knowledge with a philosophical analysis.
A cross‐sectional study on bacterial contamination on the touchscreens and posterior surfaces of smartphones of emergency department staff
Authors: Kuriyama Akira , Ienaga Shinichiro , Fujii Hiroyuki 
Published: April 2023

AbstractRationale, Aims and ObjectivesCleaning smartphones of healthcare workers (HCWs) is generally recommended; however, most previous studies on bacterial contamination of smartphones assessed touchscreens alone. This study compared the prevalence of bacterial contamination on touchscreens and posterior surfaces of smartphones owned by HCWs.MethodA cross‐sectional study of smartphones used by HCWs working at an emergency department (ED) at a Japanese tertiary care hospital was conducted. Bacteria on each surface of the smartphones were isolated separately. Descriptive statistics were used to describe the prevalence of microbial contamination on each surface of the smartphones and the types of associated bacterial species. Fisher's exact test was used to compare dichotomous outcomes.ResultsThe smartphones of 40 HCWs working in the ED of a Japanese tertiary care hospital were examined. The touchscreens and posterior surfaces were contaminated in 26 (65.0%) and 36 (90.0%) smartphones, respectively, indicating the posterior surface was more frequently contaminated (p = 0.014). Bacillus species and coagulase‐negative staphylococci were most frequently isolated from each surface of the smartphones.ConclusionsThe posterior surface of a smartphone was more significantly contaminated with bacteria than the touchscreen. Both surfaces of smartphones need to be cleaned to prevent bacterial contamination in healthcare environments.
GmJAZ3 interacts with GmRR18a and GmMYC2a to regulate seed traits in soybean
Authors: Hu Yang , Liu Yue , Tao Jian‐Jun , Lu Long , Jiang Zhi‐Hao , Wei Jun‐Jie , Wu Chun‐Mei , Yin Cui‐Cui , Li Wei , Bi Ying‐Dong , Lai Yong‐Cai , Wei Wei , Zhang Wan‐Ke , Chen Shou‐Yi , Zhang Jin‐Song 
Published: April 2023

AbstractSeed weight is usually associated with seed size and is one of the important agronomic traits that determine yield. Understanding of seed weight control is limited, especially in soybean plants. Here we show that Glycine max JASMONATE‐ZIM DOMAIN 3 (GmJAZ3), a gene identified through gene co‐expression network analysis, regulates seed‐related traits in soybean. Overexpression of GmJAZ3 promotes seed size/weight and other organ sizes in stable transgenic soybean plants likely by increasing cell proliferation. GmJAZ3 interacted with both G. max RESPONSE REGULATOR 18a (GmRR18a) and GmMYC2a to inhibit their transcriptional activation of cytokinin oxidase gene G. max CYTOKININ OXIDASE 3‐4 (GmCKX3‐4), which usually affects seed traits. Meanwhile, the GmRR18a binds to the promoter of GmMYC2a and activates GmMYC2a gene expression. In GmJAZ3‐overexpressing soybean seeds, the protein contents were increased while the fatty acid contents were reduced compared to those in the control seeds, indicating that the GmJAZ3 affects seed size/weight and compositions. Natural variation in JAZ3 promoter region was further analyzed and Hap3 promoter correlates with higher promoter activity, higher gene expression and higher seed weight. The Hap3 promoter may be selected and fixed during soybean domestication. JAZ3 orthologs from other plants/crops may also control seed size and weight. Taken together, our study reveals a novel molecular module GmJAZ3‐GmRR18a/GmMYC2a‐GmCKXs for seed size and weight control, providing promising targets during soybean molecular breeding for better seed traits.
Determinants of quality of life in frontline healthcare providers caring for COVID‐19 patients
Authors: Lan Hsiang‐Yun , Chao En , Lin Li‐Chen , Lee Wei‐Ping , Yeh Kuo‐Ming , Palmer John , Chiang Hui‐Hsun 
Published: April 2023

AbstractAims and ObjectivesTo investigate the factors affecting quality of life in healthcare providers who care for patients with COVID‐19.BackgroundHealthcare providers caring for COVID‐19 patients during the pandemic suffered a deterioration in their quality of life. Several studies have explored their psychological impact of working with COVID patients, but none have examined the causes of this deterioration.DesignA cross‐sectional study.MethodsIn the current study, the authors investigated the factors affecting quality of life in 293 healthcare providers recruited from a medical centre in northern Taiwan who had recently cared for patients with suspected or confirmed COVID‐19 by analysing their responses to an online self‐report questionnaire, using bivariate correlations and structural equation modelling. Reporting of this research adheres to the STROBE guideline.ResultsThe study identified an important sequence of factors that mediated the effects of perceived success of epidemic prevention policies, family relations problems and education level on quality of life in a sample of healthcare workers caring for COVID‐19 patients. The mediators were use of approach‐oriented coping strategies and current mental health status. Specifically, use of approach‐oriented coping strategies was found to directly cause improved quality of life and indirectly cause improved mental health, whereas use of avoidant coping strategies was found to directly cause worsening of mental health. Poor mental health predicted poor quality of life.ConclusionsResults suggest that implementation of sound epidemic prevention policies that promote adoption of approach‐oriented coping behaviour should lead to a better quality of life in the future for healthcare providers working in challenging circumstances.Relevance to Clinical PracticeAssessment of these policies as well as the providers' family relations are necessary first steps to improving the success of approach‐oriented coping behaviour in this population, which in turn can improve their mental health and quality of life.Patient or Public ContributionNeither patients nor members of the public were involved in the design or execution of the study.
Focal vibration in dysphagia: A technological treatment for severe acquired brain injury rehabilitation
Authors: Galluccio Caterina , Pazzaglia Costanza , Spaccatrosi Sara , Giovannini Silvia , Castelli Letizia , Padua Luca 
Published: April 2023

AbstractBackgroundA patient with severe acquired brain injury (sABI) may experience impairment in the physiological swallowing process. Many studies in the rehabilitation field have sought to understand the effects of local vibration therapy at various levels of the central nervous system and the possible benefits in neuro‐rehabilitation. There are few studies directed towards the use of vibratory energy for improving swallowing and phonatory function.ObjectivesThe purpose of this study is to observe the effects of integrating conventional dysphagia therapy with the focal vibration therapy in patients with sABI.MethodsThis is a pilot, randomized controlled, parallel‐arm, single‐blind study. Twenty‐eight patients with post‐sABI dysphagia were included in the study and randomized to Conventional Group (CG, conventional treatment for dysphagia) or Experimental Group (EG, conventional treatment for dysphagia plus focal vibration therapy). Patients were assessed at baseline (T0), after 4 weeks (T1) and after 8 weeks (T2) using the Dysphagia Outcome Severity Scale (DOSS) and the Bedside Swallow Assessment scale (BSAs).ResultsPatients in the experimental group showed a statistically significant change at T1 compared with T0 at DOSS (p = .014), and at BSAS between T1 and T2 (p = .024) and between T0 and T2 (p = .027). Overall, all patients improved significantly at DOSS between T0 and T1 (p < .001) and between T0 and T2 (p < .001).ConclusionThe results obtained from this pilot study are encouraging and demonstrate how the use of focal vibration therapy in add on to conventional treatment for dysphagia may be another useful tool for improving swallowing in patients with sABI.
Thyroid autoimmunity and autoimmune thyroid disease in Malaysian girls with Turner syndrome: An understudied population
Authors: Lee Yee L , Zaini Azriyanti A , Idris Arini N , Abdullah Raja A , Wong Jeanne SL , Hong Joyce SS , Hussain Suhaimi , Lim Poi G , Lim Song H , Nor Noor SM , Wu Loo L , Jalaludin Muhammad Y 
Published: April 2023

AimsKnowledge on the spectrum of thyroid disorders amongst Turner syndrome (TS) patients in Southeast Asia is limited. This study aimed to evaluate the prevalence of thyroid autoimmunity, the spectrum of autoimmune thyroid disease and association with age and karyotype amongst Malaysian TS girls.MethodsA cross‐sectional study was conducted at 11 paediatric endocrine units in Malaysia. Blood samples for antithyroglobulin antibodies, antithyroid peroxidase antibodies and thyroid function test were obtained. In patients with pre‐existing thyroid disease, information on clinical and biochemical thyroid status was obtained from medical records.ResultsNinety‐seven TS patients with a mean age of 13.4 ± 4.8 years were recruited. Thyroid autoimmunity was found in 43.8% of TS patients. Nineteen per cent of those with thyroid autoimmunity had autoimmune thyroid disease (Hashimoto thyroiditis in 7.3% and hyperthyroidism in 1% of total population). Patients with isochromosome X and patients with 45,X mosaicism or other X chromosomal abnormalities were more prone to have thyroid autoimmunity compared to those with 45,X karyotype (OR 5.09, 95% CI 1.54–16.88, P = 0.008 and OR 3.41, 95% CI 1.32–8.82, P = 0.01 respectively). The prevalence of thyroid autoimmunity increased with age (33.3% for age 0–9.9 years; 46.8% for age 10–19.9 years and 57.1% age for 20–29.9 years) with autoimmune thyroid disease detected in 14.3% during adulthood.ConclusionThyroid autoimmunity was significantly associated with the non 45,X karyotype group, particularly isochromosome X. Annual screening of thyroid function should be carried out upon diagnosis of TS until adulthood with more frequent monitoring recommended in the presence of thyroid autoimmunity.
The case for independence: Does central bank independence curb the spread of the underground economy?
Authors: Berdiev Aziz N. , Saunoris James W. 
Published: April 2023

AbstractThis paper considers an alternate dimension of government institutions associated with the separation of powers between government and its central bank. A more independent central bank is consistent with greater institutional quality and constraints on government. We propose that central bank independence influences the prevalence of the shadow, or underground, economy. Using cross‐country panel data for over 100 nations over the period 1991 to 2012, the results from instrumental variables techniques show that central bank independence curbs underground economic activity. Furthermore, considering different dimensions of independence, we find that independence related to central bank CEO, policy formation, and central bank lending are effective at checking the shadow sector. Overall, these findings are robust to a different measure of the underground economy, correcting for the potential influence of outliers, controlling for the impact of additional factors, accounting for heterogeneity related to the level of development, and considering the heterogeneity related to the prevalence of the shadow sector. The main implication of the results is that nations seeking to reduce the prevalence of the underground economy would benefit from policies that promote central bank independence.
Single‐cell segmentation in bacterial biofilms with an optimized deep learning method enables tracking of cell lineages and measurements of growth rates
Authors: Jelli Eric , Ohmura Takuya , Netter Niklas , Abt Martin , Jiménez‐Siebert Eva , Neuhaus Konstantin , Rode Daniel K. H. , Nadell Carey D. , Drescher Knut 
Published: April 2023

AbstractBacteria often grow into matrix‐encased three‐dimensional (3D) biofilm communities, which can be imaged at cellular resolution using confocal microscopy. From these 3D images, measurements of single‐cell properties with high spatiotemporal resolution are required to investigate cellular heterogeneity and dynamical processes inside biofilms. However, the required measurements rely on the automated segmentation of bacterial cells in 3D images, which is a technical challenge. To improve the accuracy of single‐cell segmentation in 3D biofilms, we first evaluated recent classical and deep learning segmentation algorithms. We then extended StarDist, a state‐of‐the‐art deep learning algorithm, by optimizing the post‐processing for bacteria, which resulted in the most accurate segmentation results for biofilms among all investigated algorithms. To generate the large 3D training dataset required for deep learning, we developed an iterative process of automated segmentation followed by semi‐manual correction, resulting in >18,000 annotated Vibrio cholerae cells in 3D images. We demonstrate that this large training dataset and the neural network with optimized post‐processing yield accurate segmentation results for biofilms of different species and on biofilm images from different microscopes. Finally, we used the accurate single‐cell segmentation results to track cell lineages in biofilms and to perform spatiotemporal measurements of single‐cell growth rates during biofilm development.
Person‐specific evidence has the ability to mobilize relational capacity: A four‐step grounded theory developed in people with long‐term health conditions
Authors: Zoffmann Vibeke , Jørgensen Rikke , Graue Marit , Biener Sigrid Normann , Brorsson Anna Lena , Christiansen Cecilie Holm , Due‐Christensen Mette , Enggaard Helle , Finderup Jeanette , Haas Josephine , Husted Gitte Reventlov , Johansen Maja Tornøe , Kanne Katja Lisa , Hope Kolltveit Beate‐Christin , Krogslund Katrine Wegmann , Lie Silje S. , Lindholm Anna Olinder , Marqvorsen Emilie H. S. , Mathiesen Anne Sophie , Olesen Mette Linnet , Rasmussen Bodil , Rothmann Mette Juel , Simonsen Susan Munch , Tackie Sara Huld Sveinsdóttir , Thisted Lise Bjerrum , Tran Trang Minh , Weis Janne , Kirkevold Marit 
Published: April 2023

AbstractPerson‐specific evidence was developed as a grounded theory by analyzing 20 selected case descriptions from interventions using the guided self‐determination method with people with various long‐term health conditions. It explains the mechanisms of mobilizing relational capacity by including person‐specific evidence in shared decision‐making. Person‐specific self‐insight was the first step, achieved as individuals completed reflection sheets enabling them to clarify their personal values and identify actions or omissions related to self‐management challenges. This step paved the way for sharing these insights and challenges in a relationship with a supportive health professional, who could then rely on person‐specific evidence instead of assumptions or a narrow disease perspective for shared decision‐making. Trust in the evidence encouraged the supportive health professional to transfer it to the interdisciplinary team. Person‐specific evidence then enhanced the ability of team members to apply general evidence in a meaningful way. The increased openness achieved by individuals through these steps enabled them to eventually share their new self‐insights in daily life with other people, decreasing loneliness they experienced in self‐management. Relational capacity, the core of the theory, is mobilized in both people with long‐term health conditions and healthcare professionals. Further research on person‐specific evidence and relational capacity in healthcare is recommended.