bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of Alfalfa SPL gene family and expression analysis under biotic and abiotic stresses
Authors: Wang Yizhen , Ruan Qian , Zhu Xiaolin , Wang Baoqiang , Wei Bochuang , Wei Xiaohong 
Published: January 2023

AbstractThe SQUAMOSA promoter binding-like protein (SPL) is a specific transcription factor that affects plant growth and development. The SPL gene family has been explored in various plants, but information about these genes in alfalfa is limited. This study, based on the whole genome data of alfalfa SPL, the fundamental physicochemical properties, phylogenetic evolution, gene structure, cis-acting elements, and gene expression of members of the MsSPL gene family were analyzed by bioinformatics methods. We identified 82 SPL sequences in the alfalfa, which were annotated into 23 genes, including 7 (30.43%) genes with four alleles, 10 (43.47%) with three, 3 (13.04%) with two, 3 (13.04%) with one allele. These SPL genes were divided into six groups, that are constructed from A. thaliana, M. truncatula and alfalfa. Chromosomal localization of the identified SPL genes showed arbitary distribution. The subcellular localization predictions showed that all MsSPL proteins were located in the nucleus. A total of 71 pairs of duplicated genes were identified, and segmental duplication mainly contributed to the expansion of the MsSPL gene family. Analysis of the Ka/Ks ratios indicated that paralogs of the MsSPL gene family principally underwent purifying selection. Protein–protein interaction analysis of MsSPL proteins were performed to predict their roles in potential regulatory networks. Twelve cis-acting elements including phytohormone and stress elements were detected in the regions of MsSPL genes. We further analyzed that the MsSPLs had apparent responses to abiotic stresses such as drought and salt and the biotic stress of methyl jasmonate. These results provide comprehensive information on the MsSPL gene family in alfalfa and lay a solid foundation for elucidating the biological functions of MsSPLs. This study also provides valuable on the regulation mechanism and function of MsSPLs in response to biotic and abiotic stresses.
rxCOV is a quantitative metric for assessing immunoassay analyte fidelity
Authors: Brand Rhonda M. , Pitlor Danielle , Metter E. Jeffrey , Dudley Beth , Karloski Eve , Zyhowski Ashley , Brand Randall E. , Uttam Shikhar 
Published: January 2023

AbstractImmunoassay based bioanalytical measurements are widely used in a variety of biomedical research and clinical settings. In these settings they are assumed to faithfully represent the experimental conditions being tested and the sample groups being compared. Although significant technical advances have been made in improving sensitivity and quality of the measurements, currently no metrics exist that objectively quantify the fidelity of the measured analytes with respect to noise associated with the specific assay. Here we introduce ratio of cross-coefficient-of-variation (rxCOV), a fidelity metric for objectively assessing immunoassay analyte measurement quality when comparing its differential expression between different sample groups or experimental conditions. We derive the metric from first principles and establish its feasibility and applicability using simulated and experimental data. We show that rxCOV assesses fidelity independent of statistical significance, and importantly, identifies when latter is meaningful. We also discuss its importance in the context of averaging experimental replicates for increasing signal to noise ratio. Finally, we demonstrate its application in a Lynch Syndrome case study. We conclude by discussing its applicability to multiplexed immunoassays, other biosensing assays, and to paired and unpaired data. We anticipate rxCOV to be adopted as a simple and easy-to-use fidelity metric for performing robust and reproducible biomedical research.
Enumeration optimization of open pit production scheduling based on mobile capacity search domain
Authors: Xu Xiaochuan , Gu Xiaowei , Wang Qing , Zhao Yunqi , Kong Wenyuan , Zhu Zhenguo , Wang Fengdan 
Published: January 2023

AbstractThe optimization of open pit mine production scheduling is not only a multistage decision-making problem but also involves space–time dynamic action among multiple factors, which makes it difficult to optimize production capacity, mining sequence, mining life, and other factors simultaneously in optimizing design. In addition, the production capacity is disorderly expanded, the calculation scale is large, and the optimization time is long. Therefore, this article designs a mobile capacity search domain method to improve computing efficiency without omitting the optimal production capacity. At the same time, taking the maximum net present value as the objective function, an enumeration method is used to optimize the possible paths in different capacity domains and calculate the infrastructure investment and facility idle cost required to meet the maximum production capacity on each possible path to control the disorderly expansion and violent fluctuation of production capacity. The research shows that the open pit mine production scheduling optimization algorithm proposed in this article can not only realize the simultaneous optimization of the three elements of production capacity, mining sequence, and mining life but also improve the computing efficiency by 200 times. Furthermore, the production capacity fluctuation is less than 1.4%. The mining life of the mine is extended by 13 years, and the overall economic benefit is increased by 18%.
Comparison of two analyzer measurements focusing on material stiffness among normal, treatment-naïve, and treated glaucoma eyes
Authors: Aoki Shuichiro , Asaoka Ryo , Fujino Yuri , Nakakura Shunsuke , Murata Hiroshi , Kiuchi Yoshiaki 
Published: January 2023

AbstractTo investigate differences in biomechanical properties focusing on stiffness parameters between normal, treatment-naïve primary open-angle glaucoma (POAG), and treated POAG eyes. Retrospective case–control study, This study included 46 treatment-naïve POAG eyes, 46 POAG eyes treated with prostaglandin analogues, and 49 normal eyes used as controls; matched in terms of age and axial length. Corneal hysteresis (CH) and corneal resistance factor (CRF) were measured using an ocular response analyzer (ORA). Fifteen biomechanical parameters were measured with the Corneal Visualization Scheimpflug Technology (Corvis ST), including biomechanical glaucoma factor (BGF) and two stiffness parameters of ‘SP A1’ and ‘stress–strain index (SSI)’, which were compared among the three groups. Additionally, the area under the curve (AUC) values of the receiver-operating curve to discriminate control and treatment-naïve POAG eyes were calculated for BGF and CH. Treatment-naïve POAG eyes had higher ‘SSI’ than normal eyes even after controlling for IOP (p < 0.05, Tukey-Cramer test). Treated POAG eyes had significantly lower CRF, and higher BGF than treatment-naïve POAG eyes. There were also significant differences in CH or SP A1 among the three groups. BGF and CH had similar AUC values (0.61 and 0.59). Treatment-naïve POAG eyes had stiffer corneas compared to normal eyes, which seemed to result from the material/structure of the cornea rather than higher intraocular pressure. Antiglaucoma topical medication alters biomechanical properties measured with Corvis ST. These results are important for understanding the pathogenesis and improving the management of POAG.
Sex/gender and socioeconomic differences in modifiable risk factors for dementia
Authors: Geraets Anouk F. J. , Leist Anja K. 
Published: January 2023

AbstractBoth sex/gender and socioeconomic differences have been reported in the prevalence of modifiable risk factors for dementia. However, it remains unclear whether the associations between modifiable risk factors for dementia and incident dementia differ by sex/gender or socioeconomic status. This study aimed to investigate sex/gender and socioeconomic differences in the associations of modifiable risk factors with incident dementia using a life-course perspective. We used data from the English Longitudinal Study of Ageing (2008/2009 to 2018/2019). A total of 8,941 individuals were included [mean (standard deviation) age, 66.1 ± 9.8 years; 4,935 (55.2%) were women]. No overall sex/gender difference in dementia risk was found. Dementia risk was higher among those who experienced childhood deprivation [hazard ratio (HR) = 1.51 (1.17; 1.96)], lower occupational attainment [HR low versus high = 1.60 (1.23; 2.09) and HR medium versus high = 1.53 (1.15; 2.06)], and low wealth [HR low versus high = 1.63 (1.26; 2.12)]. Though different associations were found among the subgroups, there might be a sex/gender difference in dementia risk only for low cognitive activity, suggesting a higher risk for women [HR = 2.61 (1.89; 3.60)] compared to men [HR = 1.73 (1.20; 2.49)]. No consistent socioeconomic differences in modifiable dementia risk were found. A population-based approach that tackles inequalities in dementia risk profiles directly may be more effective than individual approaches in dementia prevention.
Multi-port real-time observation for ultrafast intracavitary evolution dynamics
Authors: Du Yufan , Chen Liao , Lei Zihui , Zhang Chi , Zhao Luming , Zhang Xinliang 
Published: January 2023

AbstractRecent advances in real-time spectral measurements of a mode-locked fiber laser have found many intriguing phenomena and which have verified the soliton theory. However, most current results are based on laser single-port observation, and are rarely involved in the cavity evolution, which also has rich nonlinear dynamics according to the soliton theory. Here we present an approach for the intracavitary soliton evolution processes, where spectra from multi-ports are collected in time-division multiplexed sequence to realize synchronous real-time observation. The sinusoidal evolution of the spectral beating is observed clearly, agreeing with the reported prediction. Furthermore, the intracavitary spectral dynamics of the period-doubling bifurcation are also revealed. Our scheme observed the spectral expanding and shrinking alternately and periodically over two round trips, matching well with simulations. This work may open up possibilities for real-time observation of various intracavitary nonlinear dynamics in photonic systems.
Early Cretaceous marine incursions into South Atlantic rift basins originated from the south
Authors: Cui Xingqian , Wignall Brent , Freeman Katherine H. , Summons Roger E. 
Published: January 2023

AbstractThe breakup of Gondwana resulted in sedimentary deposits recording lacustrine to marine environmental transitions in the South Atlantic rift basins during the Early Cretaceous. Currently, ambiguity pervades our understanding of the timing and orientation of the initial seawater incursion. Here we investigated hydrocarbon biomarkers in sediments from two drill cores off West Africa with stratigraphic coverage from the Berriasian-Barremian to Albian. Based on biomarkers that can distinguish non-marine from marine-influenced settings, initial seawater influx occurred through the southern entrance across the Rio Grande Rise-Walvis Ridge during the early Aptian stage. Transitional conditions prevailed during the Aptian stage as the seawater incursion induced microbial community and environmental reorganization until the Albian when fully marine conditions prevailed. Overall, results of this study are valuable in deciphering the final opening of the South Atlantic Ocean, fulfilling the global comparison of paleoenvironments, and facilitating future petroleum exploration along the South Atlantic conjugate margins.
Ultrathin black TiO2 nanosheet-assembled microspheres with high stability for efficient solar-driven photocatalytic hydrogen evolution
Authors: Wang Chunyan , Kang Xin , Liu Jiancong , Wang Dongxu , Wang Nan , Chen Jie , Wang Jing , Tian Chungui , Fu Honggang 
Published: January 2023

We applied a small amine molecule protective agent to synthesize high-thermally stable black TiO2 with high specific surface area, broad optical absorption, and increased charge separation, which exhibits excellent photocatalytic performance.
Replication in Evidence-Based Aphasia Treatments
Authors: Karidas Stephanie , Hinckley Jacqueline J. , Brekher Izabelle 
Published: January 2023

Purpose:
A critical review was completed to evaluate replication of aphasia treatments that have been vetted and accepted on the American Speech-Language-Hearing Association Practice Portal.

Method:
The electronic databases Academic Search Premier, ProQuest Central, CINAHL Complete, and ERIC were searched for relevant articles using treatment names as keywords. Coders compared stimuli, material, design, and statistical analysis to pilot treatment approaches. Each study was coded as direct, conceptual, failed, or no replication.

Results:
Eighteen treatment approaches were selected for this review. A total of 188 articles met the inclusion criteria. Results revealed that 14 out of 18 treatment approaches were somehow replicated. Direct replications as the most valuable replication type for affirming previously found results were represented in only 1.5% of all studies (3/188). Failed direct replication were at 2% overall (4/188). Conceptual replications were more common across treatment approaches, but also represented at a low level with 22.8% (43/188). The majority of studies were coded as no replication attempt with 73.4%.

Discussion:
A critical factor in developing an evidence-based practice is the existence of replicated results for treatment. Replication evaluates the reproducibility of an author's or authors' research methodology and resulting outcomes and helps to ensure that observed treatment effects are reproducible. For an evidence-based treatment to be implemented or used in any clinical setting, it must be one that can be replicated. Direct and conceptual replications of aphasia treatment approaches were found to be alarmingly low considering the importance of replication in our field. It is recommended that replication should become more valued and mainstreamed in aphasia research. A replication database that compiles and maintains treatment manuals for replication purposes can increase the accessibility and acceptability of replications for researchers.
A dynamic relative displacement evaluation method for extra‐high voltage transformer withstanding short‐circuit impact
Authors: Ou Qiang , Luo Longfu , Li Yong , Lin Yantao , Tian Ye 
Published: January 2023

AbstractThe extra‐high voltage (EHV) transformer winding disks are subjected to dynamic electromagnetic forces caused by short‐circuit currents. These periodically decaying impact forces may endanger the safety of the transformer. The winding constraint conditions around the circumference are different due to the influence of axial pressure structures and magnetic boundaries. Moreover, this difference becomes more evident as the voltage and capacity increase. To investigate the spatial differences and time effects of EHV transformer short‐circuit faults, this paper proposes a reliability evaluation method based on dynamic relative displacement (DRDEM) for the first time. Firstly, the suitable and efficient analysis method is summarized by comparing the deviation among different calculated impedances and the measured value. Then, the space‐time effect of windings is obtained by the static magnetic field and dynamic structural field based on equivalent compression supports. Furthermore, a 50 MVA/110 kV transformer is designed for the destructive short‐circuit test to simulate the short‐circuit ability feature of the EHV transformer. The disassembly phenomena after all the tests indicate that the DRDEM is more adaptable in characterizing the winding ability to withstand short circuit when investigating the spatial differences and time effects.
A Xanthoceras sorbifolium crack segmentation method based on an improved level set
Authors: Zhang Dan , Li Tieshan , Philip Chen C.L. , Wang Li 
Published: January 2023

AbstractThe dehiscence of the Xanthoceras sorbifolium (X. sorbifolium) may lead to seeds jump out and economic loss. The shape and the degree of the crack will provide the relevant elements for the study of the X. sorbifolium dehiscence and duly picked. Therefore, an improved level set method is proposed for X. sorbifolium crack segmentation. The problems of intensity inhomogeneity and so on, which pose challenges for accurate crack segmentation. The local Gaussian distribution fitting method has a good segmentation effect, but it is sensitive to the initial contour and does not use gradient information, which affects the accurate location of the edge. Aiming at the above problems and the scene of crack segmentation, this paper firstly adopts histogram threshold method to obtain the initial contour automatically. Secondly, the energy function is constructed by combining local and edge information. Finally, the double‐well potential function is used to reduce the oscillation and distortion of the method. In this paper, the experiment results show that the average boundary precision is 88.25% and average segmentation time of each image is 12.7s of the proposed method. After comprehensive analysis of IoU and boundary recall, the method in this paper achieves better results.
Bedeutung des differenzierten
Säuglingsbefunds
Authors: Ginsberg Iris 
Published: January 2023

ZUSAMMENFASSUNGIndikationen zur Osteopathie beim jungen Säugling. Bedeutung
der Einbeziehung der Mutter/des Vaters des Säuglings
bei Befundung und Behandlung. Differenzierter neurologischer
Befund und Palpationsbefund. Bedeutung des Re-Befunds.
The link between foreign institutional owners and multinational enterprises’ environmental outcomes
Authors: Ellimäki Pia , Aguilera Ruth V. , Hurtado-Torres Nuria Esther , Aragón-Correa J. Alberto 
Published: January 2023

AbstractMany institutional investors claim to be leaders in their commitment to sustainability, yet their real impact is undetermined. We look at the relationship between the presence of foreign institutional owners and the firm’s environmental outcomes in terms of performance and innovation. We argue that foreign institutional owners seek to mitigate their exposure to reputational risks by encouraging their investee firms to move towards better environmental performance. However, these owners are less likely to engage in long-term investments derived from environmental innovations. We examine these paradoxical motivations in the context of multinational enterprises (MNEs) in the chemical industry across 33 countries in emerging and developed markets and further explore how these investee firms’ international diversification affects these relationships. Our findings contribute to international corporate governance and sustainability research by uncovering that, contrary to institutional owners’ popular claims, foreign institutional owners have a positive effect on their investees’ environmental performance, but their influence is not statistically significant on environmental innovation. Specifically, the influence of foreign institutional owners on environmental performance is strong for MNEs with a low level of international diversification and marginal for those with a higher level of internationalization; meanwhile, domestic institutional owners are committed to advancing both environmental performance and innovation in their MNE investees. In sum, we show that environmental concerns are still quite localized.
Motivations for user satisfaction of mobile fitness applications: An analysis of user experience based on online review comments
Authors: Ahn Hyeongjin , Park Eunil 
Published: January 2023

AbstractConsidering that mobile fitness applications are one of the necessities in our lives, the user perspective toward the application is a prominent research topic in both academia and industry with the goal of improving such services. Thus, this study applies two different natural language processing approaches, bag-of-words, and sentiment analysis, to online review comments of the applications to examine the effects of user experience elements. The review dataset collected from 16,461 users, after pre-processing, revealed the notable roles of perceived affection and hedonic values in determining user satisfaction with the application, whereas the effect of user burden on satisfaction was marginal. Several implications, as well as limitations of the study, were examined incorporating the findings with the statistical results.
Conceptual design of a GEM (gas electron multiplier) based gas Cherenkov detector for measurement of 17 MeV gamma rays from T(D, γ)5He in magnetic confinement fusion plasmas
Authors: Putignano O. , Croci G. , Muraro A. , Cancelli S. , Caruggi F. , Gorini G. , Grosso G. , Kushoro M. H. , Marcer G. , Nocente M. , Cippo E. Perelli , Rebai M. , Rigamonti D. , Tardocchi M. 
Published: January 2023

The only method for assessing the fusion power throughput of a deuterium–tritium (DT) reactor presently relies on determining the absolute number of 14 MeV neutrons produced in the DT plasma. An independent method, developed and investigated during the recent DT campaign at the Joint European Torus, is based on the absolute counting of 17 MeV gamma rays produced by the competing T(D, γ)5He reaction that features a very weak branching ratio (about 3–6 × 10−6) when compared to the main T(D, n)4He reaction. The state-of-the-art spectrometer used for gamma-ray measurements in magnetic confinement fusion plasmas is LaBr3(Ce) scintillator detectors, although they require significant neutron shielding to extract a relatively weak gamma-ray signal from a much more abundant neutron field. A better approach relies on a gamma-ray detector that is intrinsically insensitive to neutrons. We have advanced the design of a gamma-ray counter based on the Cherenkov effect for gamma-rays whose energy exceeds 11 MeV, optimized to work in the neutron-rich environment of a steady-state, magnetically confined fusion plasma device. The gamma-rays interact with an aluminum window and extract electrons that move into the radiator emitting photons via the Cherenkov effect. Since the Cherenkov light consists of few photons (25 on average) in the far UV band (100–200 nm), a pre-amplifier is required to transport the photons to the neutron-shielded location, which may be a few meters away, where the readout elements of the detector, either a silicon or standard photomultiplier tube, are placed. The present work focuses on the development of a scintillating GEM (Gas Electron Multiplier) based pre-amplifier that acts as a Cherenkov photon pre-amplifier and wavelength shifter. This paper presents the result of a set of Garfield++ simulations developed to find the optimal GEM working parameters. A photon gain of 100 is obtained by biasing a single GEM foil to 1 kV.
Ultra-low noise, bi-polar, programmable current sources
Authors: Mrozowski M. S. , Chalmers I. C. , Ingleby S. J. , Griffin P. F. , Riis E. 
Published: January 2023

We present the design process and implementation of fully open-source, ultra-low noise programmable current source systems in two configurations. Although originally designed as coil drivers for Optically Pumped Magnetometers (OPMs), the device specifications make them potentially useful in a range of applications. The devices feature a bi-directional current range of ±10 and ±250 mA on three independent channels with 16-bit resolution. Both devices feature a narrow 1/f noise bandwidth of 1 Hz, enabling magnetic field manipulation for high-performance OPMs. They exhibit a low noise of 146 pA/Hz and 4.1 nA/Hz, which translates to 15 and 16 ppb/Hz noise relative to full scale.