bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Australian public worries more about losing species than the costs of keeping them
Authors: Zander Kerstin K , Burton Michael , Pandit Ram , Garnett Stephen T 
Published: March 2023

SummaryGovernment conservation measures will always depend on public support. While more has been learnt about which species the public values and which conservation measures are socially acceptable, less is known about the criteria that the public thinks government should consider when making conservation investment decisions. This study uses a stated preference best–worst scaling method to gauge the views of a sample of the Australian public on what they think government should consider when allocating funding to threatened species conservation. We found that the three most important factors were the risk that a species might become extinct, the likelihood that a conservation intervention might be effective and the risk of unintended consequences for other species that could potentially arise if the measure was implemented. Costs of conservation measures and the degree to which the society accepts these costs were considered much less important. The latter aspect was consistent with the high level of trust that respondents placed in the judgement of experts and scientists concerning threatened species conservation. We conclude that the Australian Government has a societal mandate to spend more money on threatened species conservation, provided that there is little risk and that it is backed up by science.
‘The rain soaked sky is leaden’: Welsh Identity and Dystopian Impulses inThe Doctor of Myddfai
Authors: Jones Nicholas 
Published: March 2023

AbstractThe Doctor of Myddfai(1995), Peter Maxwell Davies's third full-scale opera and his first collaboration with David Pountney, is a work that occupies an important position within the composer's output for the opera house and theatre. However, whereas a significant amount of scholarly attention has been afforded to Davies's music-theatre works of the 1960s and the operasTaverner(1962–8) andResurrection(1986–7),The Doctor of Myddfaihas been somewhat neglected by comparison. This article examines the opera from two perspectives. The first addresses the work's dystopian setting and argues that key issues highlighted in the libretto – especially in relation to certain political concerns and environmental anxieties – have a strong contemporary resonance. The second focuses on the opera's articulation of Welsh identity, particularly through the use of Welsh folklore, native landscape and place, and indigenous musical signifiers. The intersection of these two elements – the work's celebration of Welshness and its dystopian qualities – imbues the opera with an intrinsic yet highly productive sense of tension and opposition: characteristics that drive the work towards its compelling conclusion.
Risk factors for long post-operative hospital stays after cardiopulmonary bypass surgery in full-term neonates
Authors: Asfari Ahmed , Borasino Santiago , Mendoza Erika , Hock Kristal M. , Huskey Jordan L. , Rahman A.K.M. Fazlur , Zaccagni Hayden , Byrnes Jonathan W. 
Published: March 2023

AbstractBackground:Long hospital stays for neonates following cardiac surgery can be detrimental to short- and long-term outcomes. Furthermore, it can impact resource allocation within heart centres' daily operations. We aimed to explore multiple clinical variables and complications that can influence and predict the post-operative hospital length of stay.Methods:We conducted a retrospective observational review of the full-term neonates (<30 days old) who had cardiac surgery in a tertiary paediatric cardiac surgery centre – assessment of multiple clinical variables and their association with post-operative hospital length of stay.Results:A total of 273 neonates were screened with a mortality rate of 8%. The survivors (number = 251) were analysed; 83% had at least one complication. The median post-operative hospital length of stay was 19.5 days (interquartile range 10.5, 31.6 days). The median post-operative hospital length of stay was significantly different among patients with complications (21.5 days, 10.5, 34.6 days) versus the no-complication group (14 days, 9.6, 19.5 days), p < 0.01. Among the non-modifiable variables, gastrostomy, tracheostomy, syndromes, and single ventricle physiology are significantly associated with longer post-operative hospital length of stay. Among the modifiable variables, deep vein thrombosis and cardiac arrest were associated with extended post-operative hospital length of stay.Conclusions:Complications following cardiac surgery can be associated with longer hospital stay. Some complications are modifiable. Deep vein thrombosis and cardiac arrest are among the complications that were associated with longer hospital stay and offer a direct opportunity for prevention which may be reflected in better outcomes and shorter hospital stay.
Cognition in adults with borderline personality disorder
Authors: Aslan Ibrahim H. , Grant Jon E. , Chamberlain Samuel R. 
Published: March 2023

AbstractObjectiveBorderline personality disorder (BPD) is a common and disabling mental health disorder and has detrimental effects on affected individuals across multiple domains. We aimed to investigate whether individuals with BPD differ from control subjects in terms of cognitive functions, and to see if there is a relationship between cognitive functions, impulsivity, and BPD symptom severity.MethodsBPD individuals (n = 26; mean age = 26.7; 69.2% female) and controls (n = 58; mean age = 25.3; 51.7% female) were enrolled. Intra/Extra-Dimensional Set Shift (IED) and One Touch Stockings of Cambridge (OTS) tasks from the Cambridge Neuropsychological Test Automated Battery (CANTAB) were used to assess cognitive functions. Barratt Impulsivity Scale-version 11 (BIS−11) was administered to measure impulsivity and both the Zanarini Scale for Borderline Personality Disorder self-report and the clinician-administered versions were used to assess BPD symptom severity.ResultsBPD group showed significantly impaired cognitive performance on the IED task versus controls, but there was not a significant difference in the OTS task. BPD symptom severity was positively correlated with trait (BIS-11) impulsivity and no correlation was found between BPD symptom severity and cognitive functions.ConclusionsThis study suggests people with BPD experience impaired cognitive flexibility and heightened impulsivity. Only impulsivity appeared to be directly related to symptom severity, perhaps indicating that cognitive inflexibility could be a vulnerability marker. Future research should focus on a longitudinal approach to extend clinical and theoretical knowledge in this area.
Dynamics of the December 2020 Ash‐Poor Plume Formed by Lava‐Water Interaction at the Summit of Kīlauea Volcano, Hawaiʻi
Authors: Cahalan Ryan C. , Mastin Larry G. , Van Eaton Alexa R. , Hurwitz Shaul , Smith Adam B. , Dufek Josef , Solovitz Stephen A. , Patrick Matt , Schmith Johanne , Parcheta Carolyn , Thelen Weston A. , Downs Drew T. 
Published: March 2023

AbstractOn 20 December 2020, after more than 2 years of quiescence at Kīlauea Volcano, Hawaiʻi, renewed volcanic activity in the summit crater caused boiling of the water lake over a period of ∼90 min. The resulting water‐rich, electrified plume rose to 11–13 km above sea level, which is among the highest plumes on record for Kīlauea. Although conventional models would infer a high mass flux from explosive magma‐water interaction, the plume was not associated with an infrasound signal indicative of “explosive” activity, nor did it produce a measurable ash‐fall deposit. We use multisensor data to characterize lava‐water interaction and plume generation during this opening phase of the 2020–21 eruption. Satellite, weather radar, and eyewitness observations revealed that the plume was rich in water vapor and hydrometeors but transported less ash than expected from its maximum height. Volcanic lightning flashes detected by ground‐based cameras were confined to freezing altitudes of the upper cloud, suggesting that the ice formation drove the electrification of this plume. The low acoustic energy from lava‐water interaction points to a weakly explosive style of hydrovolcanism. Heat transfer calculations show that the lava to water heat flux was sufficient to boil the lake within 90 min. Limited mixing of lava and water inhibited major steam explosions and fine fragmentation. Results from one‐dimensional plume modeling suggest that the models may underpredict plume height due to overestimation of crosswind air‐entrainment. Our findings shed light on an unusual style of volcanism in which weakly explosive lava‐water interaction generated an outsized plume.
Multi‐Model Ensembles for Upper Atmosphere Models
Authors: Elvidge S. , Granados S. R. , Angling M. J. , Brown M. K. , Themens D. R. , Wood A. G. 
Published: March 2023

AbstractMulti‐model ensembles (MMEs) are used to improve the forecasts of thermospheric neutral densities. A variety of algorithms for constructing the model weights for the MMEs are described and have been implemented including: performance weighting, independence weighting, and non‐negative least squares. Using both empirical and physics‐based models, compared against in situ Challenging Minisatellite Payload (CHAMP) observations, the skill of each MME weighting approach has been tested in both solar minimum and maximum conditions. In both cases the MME performs better than any individual model. A non‐negative least squares weighting for the MME on a set of bias corrected models provides a 68% and 50% reduction in the mean square error compared to the best model (Jacchia‐Bowman 2008) in the solar minimum and maximum cases, respectively.
Inhibition of ERK1/2 signaling prevents bone marrow fibrosis by reducing osteopontin plasma levels in a myelofibrosis mouse model
Authors: Bianchi Elisa , Rontauroli Sebastiano , Tavernari Lara , Mirabile Margherita , Pedrazzi Francesca , Genovese Elena , Sartini Stefano , Dall’Ora Massimiliano , Grisendi Giulia , Fabbiani Luca , Maccaferri Monica , Carretta Chiara , Parenti Sandra , Fantini Sebastian , Bartalucci Niccolò , Calabresi Laura , Balliu Manjola , Guglielmelli Paola , Potenza Leonardo , Tagliafico Enrico , Losi Lorena , Dominici Massimo , Luppi Mario , Vannucchi Alessandro Maria , Manfredini Rossella 
Published: March 2023

AbstractClonal myeloproliferation and development of bone marrow (BM) fibrosis are the major pathogenetic events in myelofibrosis (MF). The identification of novel antifibrotic strategies is of utmost importance since the effectiveness of current therapies in reverting BM fibrosis is debated. We previously demonstrated that osteopontin (OPN) has a profibrotic role in MF by promoting mesenchymal stromal cells proliferation and collagen production. Moreover, increased plasma OPN correlated with higher BM fibrosis grade and inferior overall survival in MF patients. To understand whether OPN is a druggable target in MF, we assessed putative inhibitors of OPN expression in vitro and identified ERK1/2 as a major regulator of OPN production. Increased OPN plasma levels were associated with BM fibrosis development in the Romiplostim-induced MF mouse model. Moreover, ERK1/2 inhibition led to a remarkable reduction of OPN production and BM fibrosis in Romiplostim-treated mice. Strikingly, the antifibrotic effect of ERK1/2 inhibition can be mainly ascribed to the reduced OPN production since it could be recapitulated through the administration of anti-OPN neutralizing antibody. Our results demonstrate that OPN is a novel druggable target in MF and pave the way to antifibrotic therapies based on the inhibition of ERK1/2-driven OPN production or the neutralization of OPN activity.
All-optical image classification through unknown random diffusers using a single-pixel diffractive network
Authors: Bai Bijie , Li Yuhang , Luo Yi , Li Xurong , Çetintaş Ege , Jarrahi Mona , Ozcan Aydogan 
Published: March 2023

AbstractClassification of an object behind a random and unknown scattering medium sets a challenging task for computational imaging and machine vision fields. Recent deep learning-based approaches demonstrated the classification of objects using diffuser-distorted patterns collected by an image sensor. These methods demand relatively large-scale computing using deep neural networks running on digital computers. Here, we present an all-optical processor to directly classify unknown objects through unknown, random phase diffusers using broadband illumination detected with a single pixel. A set of transmissive diffractive layers, optimized using deep learning, forms a physical network that all-optically maps the spatial information of an input object behind a random diffuser into the power spectrum of the output light detected through a single pixel at the output plane of the diffractive network. We numerically demonstrated the accuracy of this framework using broadband radiation to classify unknown handwritten digits through random new diffusers, never used during the training phase, and achieved a blind testing accuracy of 87.74 ± 1.12%. We also experimentally validated our single-pixel broadband diffractive network by classifying handwritten digits “0” and “1” through a random diffuser using terahertz waves and a 3D-printed diffractive network. This single-pixel all-optical object classification system through random diffusers is based on passive diffractive layers that process broadband input light and can operate at any part of the electromagnetic spectrum by simply scaling the diffractive features proportional to the wavelength range of interest. These results have various potential applications in, e.g., biomedical imaging, security, robotics, and autonomous driving.
Severity of cystoid macular oedema in preterm infants observed using hand-held spectral domain optical coherence tomography improves weekly with postmenstrual age
Authors: Anwar Samira , Nath Mintu , Gottlob Irene , Proudlock F. A. 
Published: March 2023

Abstract
Objective
To investigate the relationship between cystoid macular oedema (CMO) measured in preterm infants using hand-held spectral domain optical coherence tomography (HH SD-OCT), with gestational age at birth (GA), birthweight (BW), diagnosis of retinopathy of prematurity (ROP) and the presence or absence of the external limiting membrane (ELM).

Methods
We conducted a prospective mixed cross-sectional/longitudinal observational study of 112 participants (23 to 36 weeks GA; n = 25 with, and n = 87 without, CMO). Retinal images were acquired using 344 HH SD-OCT (n = 66 with and n = 278 without, CMO) between 31 to 44 weeks postmenstrual age (PMA). CMO type (‘fovea’ and ‘dome’) was measured using thickness, width, area and peak.

Results
CMO was observed in 22.9% of preterm infants, and 19.2% of images. The mean values for thickness, width, area and peak of ‘dome’ CMO were 128.47 µm (SD +/- 34.23), 3624.45 µm (SD +/- 1323.03), 0.49 mm2 (SD +/- 0.28) and 279.81 µm (SD +/- 13.57) respectively. The mean values for thickness, width, area and peak of ‘fovea’ CMO were 64.37 µm (SD +/- 17.11), 2226.28 µm (SD +/- 1123.82), 0.16 mm2 (SD +/- 0.11) and 95.03 µm (SD +/- 26.99) respectively. Thickness, area width and peak were significantly greater for ‘dome CMO compared with ‘fovea’ CMO (P < 0.0001 for thickness, area and peak; P < 0.01 for width). Area and width significantly decreased with PMA for ‘dome’ and ‘fovea’ CMO (p = 0.0028; p < 0.001 respectively). No association was found between the presence of ROP and the detection of CMO or detection of CMO with absence of ELM.

Conclusions
HH -OCT in preterm infants demonstrates that the severity of CMO appearance improves each week for both fovea and dome CMO.
Existence of processes violating causal inequalities on time-delocalised subsystems
Authors: Wechs Julian , Branciard Cyril , Oreshkov Ognyan 
Published: March 2023

AbstractIt has been shown that it is theoretically possible for there to exist quantum and classical processes in which the operations performed by separate parties do not occur in a well-defined causal order. A central question is whether and how such processes can be realised in practice. In order to provide a rigorous framework for the notion that certain such processes have a realisation in standard quantum theory, the concept of time-delocalised quantum subsystem has been introduced. In this paper, we show that realisations on time-delocalised subsystems exist for all unitary extensions of tripartite processes. This class contains processes that violate causal inequalities, i.e., that can generate correlations that witness the incompatibility with definite causal order in a device-independent manner, and whose realisability has been a central open problem. We consider a known example of such a tripartite classical process that has a unitary extension, and study its realisation on time-delocalised subsystems. We then discuss this finding with regard to the assumptions that underlie causal inequalities, and argue that they are indeed a meaningful concept to show the absence of a definite causal order between the variables of interest.
Efficient in planta production of amidated antimicrobial peptides that are active against drug-resistant ESKAPE pathogens
Authors: Chaudhary Shahid , Ali Zahir , Tehseen Muhammad , Haney Evan F. , Pantoja-Angles Aarón , Alshehri Salwa , Wang Tiannyu , Clancy Gerard J. , Ayach Maya , Hauser Charlotte , Hong Pei-Ying , Hamdan Samir M. , Hancock Robert E. W. , Mahfouz Magdy 
Published: March 2023

AbstractAntimicrobial peptides (AMPs) are promising next-generation antibiotics that can be used to combat drug-resistant pathogens. However, the high cost involved in AMP synthesis and their short plasma half-life render their clinical translation a challenge. To address these shortcomings, we report efficient production of bioactive amidated AMPs by transient expression of glycine-extended AMPs in Nicotiana benthamiana line expressing the mammalian enzyme peptidylglycine α-amidating mono-oxygenase (PAM). Cationic AMPs accumulate to substantial levels in PAM transgenic plants compare to nontransgenic N. benthamiana. Moreover, AMPs purified from plants exhibit robust killing activity against six highly virulent and antibiotic resistant ESKAPE pathogens, prevent their biofilm formation, analogous to their synthetic counterparts and synergize with antibiotics. We also perform a base case techno-economic analysis of our platform, demonstrating the potential economic advantages and scalability for industrial use. Taken together, our experimental data and techno-economic analysis demonstrate the potential use of plant chassis for large-scale production of clinical-grade AMPs.
A contractile injection system is required for developmentally regulated cell death in Streptomyces coelicolor
Authors: Vladimirov Maria , Zhang Ruo Xi , Mak Stefanie , Nodwell Justin R. , Davidson Alan R. 
Published: March 2023

AbstractDiverse bacterial species produce extracellular contractile injection systems (eCISs). Although closely related to contractile phage tails, eCISs can inject toxic proteins into eukaryotic cells. Thus, these systems are commonly viewed as cytotoxic defense mechanisms that are not central to other aspects of bacterial biology. Here, we provide evidence that eCISs appear to participate in the complex developmental process of the bacterium Streptomyces coelicolor. In particular, we show that S. coelicolor produces eCIS particles during its normal growth cycle, and that strains lacking functional eCIS particles exhibit pronounced alterations in their developmental program. Furthermore, eCIS-deficient mutants display reduced levels of cell death and altered morphology during growth in liquid media. Our results suggest that the main role of eCISs in S. coelicolor is to modulate the developmental switch that leads to aerial hyphae formation and sporulation, rather than to attack other species.
Limits to the strain engineering of layered square-planar nickelate thin films
Authors: Ferenc Segedin Dan , Goodge Berit H. , Pan Grace A. , Song Qi , LaBollita Harrison , Jung Myung-Chul , El-Sherif Hesham , Doyle Spencer , Turkiewicz Ari , Taylor Nicole K. , Mason Jarad A. , N’Diaye Alpha T. , Paik Hanjong , El Baggari Ismail , Botana Antia S. , Kourkoutis Lena F. , Brooks Charles M. , Mundy Julia A. 
Published: March 2023

AbstractThe layered square-planar nickelates, Ndn+1NinO2n+2, are an appealing system to tune the electronic properties of square-planar nickelates via dimensionality; indeed, superconductivity was recently observed in Nd6Ni5O12 thin films. Here, we investigate the role of epitaxial strain in the competing requirements for the synthesis of the n = 3 Ruddlesden-Popper compound, Nd4Ni3O10, and subsequent reduction to the square-planar phase, Nd4Ni3O8. We synthesize our highest quality Nd4Ni3O10 films under compressive strain on LaAlO3 (001), while Nd4Ni3O10 on NdGaO3 (110) exhibits tensile strain-induced rock salt faults but retains bulk-like transport properties. A high density of extended defects forms in Nd4Ni3O10 on SrTiO3 (001). Films reduced on LaAlO3 become insulating and form compressive strain-induced c-axis canting defects, while Nd4Ni3O8 films on NdGaO3 are metallic. This work provides a pathway to the synthesis of Ndn+1NinO2n+2 thin films and sets limits on the ability to strain engineer these compounds via epitaxy.
Heterogeneous intercalated metal-organic framework active materials for fast-charging non-aqueous Li-ion capacitors
Authors: Ogihara Nobuhiro , Hasegawa Masaki , Kumagai Hitoshi , Mikita Riho , Nagasako Naoyuki 
Published: March 2023

AbstractIntercalated metal-organic frameworks (iMOFs) based on aromatic dicarboxylate are appealing negative electrode active materials for Li-based electrochemical energy storage devices. They store Li ions at approximately 0.8 V vs. Li/Li+ and, thus, avoid Li metal plating during cell operation. However, their fast-charging capability is limited. Here, to circumvent this issue, we propose iMOFs with multi-aromatic units selected using machine learning and synthesized via solution spray drying. A naphthalene-based multivariate material with nanometric thickness allows the reversible storage of Li-ions in non-aqueous Li metal cell configuration reaching 85% capacity retention at 400 mA g−1 (i.e., 30 min for full charge) and 20 °C compared to cycling at 20 mA g−1 (i.e., 10 h for full charge). The same material, tested in combination with an activated carbon-based positive electrode, enables a discharge capacity retention of about 91% after 1000 cycles at 0.15 mA cm−2 (i.e., 2 h for full charge) and 20 °C. We elucidate the charge storage mechanism and demonstrate that during Li intercalation, the distorted crystal structure promotes electron delocalization by controlling the frame vibration. As a result, a phase transition suppresses phase separation, thus, benefitting the electrode’s fast charging behavior.