bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of COVID-19 on Water Consumption Habits in Kocaeli, Turkey
Authors: Görenekli Kasım , Gülbağ Ali 
Published: April 2023

Abstract
Water is essential for living things and cannot be substituted. The rapidly growing world population causes people to change their needs and habits. The need for water is increasing day by day. In order to maintain water distribution continuously, water must be used economically. Considering that Turkey's per capita water amount is below the world average in terms of geographical location, we cannot say that the Turkey is rich in water resources. It is inevitable that we ensure the efficiency and sustainability of existing water supplies, by making use of existing hardware and software technologies. Climate changes affect water resources. The affects of Covid-19 were significiantly high during the lockdown. Throughout history, disease outbreaks have affected people's lifestyles and habits. As a result, it is important to forecast water demand during such periods. According to the hourly data collected from 33 households, water consumption during the pandemic increased by 27.93% compared to the pre-pandemic period. However, based on the monthly water consumption data, it was observed that the water consumption per household in 2022 increased by 1.04% compared to the pre-pandemic period in 2019 in Kocaeli.
Charge Transfer Processes In Granulated Mg3Sb2 Particles
Authors: o'g'li Omonboev Fazliddin Lutfiddin , Teshaboyevich Mamadalimov Abdug’apfur 
Published: April 2023

Abstract
In the article, temperature dependence of specific resistance (ρ), concentration of charge carriers (n) and mobility (µ) was studied experimentally at T = 300–700 K to study charge transfer processes in granulated Mg3Sb2 particles. The research results were explained on the basis of the charge transfer mechanism in Mg3Sb2 particles. In particular, at the initial stage of temperature increase, Т≤375 К, localized traps with energy level Ein appear in the interparticle boundary areas of the heated part of the sample. When charge carriers are trapped in them, ρ increases sharply, and n decreases. In the later stages of temperature increase, the thermal phenomenon increases along the length of the sample. In this process, localized traps with energy level Ein appear successively in the interparticle boundary regions located along the length of the sample. In relation to the charges held in them, the concentration of the generated charge carriers n increases in accordance with the increase in temperature, in this case ρ changes steadily. The increase of the potential barrier height in the interparticle boundary regions from ϕ ∼ 0.411 eV to 0.91 eV confirms the above considerations. In addition, under the influence of temperature, the particle size and impurity ionization in the interparticle boundary areas or thermal fluctuations of the crystal lattice decrease the free movement path of the carriers. This leads to a decrease in µ at T = 300–700 K.
Influence of cold plasma and ultrasonication on the extraction efficiency and quality of oil from milk thistle seeds (Silybum marianum L)
Authors: Samandari Kamyab , Fathi-Achachlouei Bahram , Azadmard-Damirchi Sodief , Borhanian Jafar , Jalali-Jivan Mehdi , Assadpour Elham , Jafari Seid Mahdi 
Published: April 2023

AbstractThe current study was attempted to evaluate the effect of cold plasma (CP; 10 and 15 min) and ultrasonication (UT; 20 and 30 min) on the oil extraction efficiency (OEE) from Milk Thistle Seed (MTS) along with determining the quality parameters of the extracted oil, e.g. Rancimat oxidative stability, acidity value (AV), peroxide value (PV), total phenolic content and antioxidant capacity over storage times (1, 30 and 60 days, T:4 °C). Our results revealed that treatment of MTS by CP and UT increased the OEE up to 29% (15 min) and 24% (30 min), respectively. In addition, applying these treatments to oil extraction led to lower AV (CP:49%, UT:46%) and PV (CP:38%, UT:35%) following 60 days’ storage. Moreover, the oil of treated MTS had higher phenolic content (CP:74%, UT:66%) and antioxidant activity (CP:156%, UT:127%) compared to samples extracted without any treatment. Besides, applying CP for 15 min increased the amount of α-tocopherol (157%), while UT (30 min) reduced its content (76%). Also, examination of fatty acid profile showed that CP (15 min) increased linolenic acid (2.8%) and arachidonic acid (35%) and decreased oleic acid (1.66%) and linoleic acid (2.1%), whereas UT (30 min) increased linoleic acid (0.27%), linolenic acid (8%) and arachidonic acid (41%) and decreased oleic acid (2%) in final oil samples. To conclude, results of this study noticed that introducing CP and UT have remarkable capabilities to improve both the OEE and oil quality which could be beneficial from both economic and quality viewpoints for the industry.
Multivariate analyses on male factors and construction of a nomogram for predicting low in vitro fertilization rate
Authors: Lin Mengyuan , He Qingwen , Wang Honghua , Wang Yan , Jiang Shi-Wen 
Published: April 2023

Abstract
Objective Low fertilization rate (LFR) and total fertilization failure (TFF) are often encountered in routine IVF procedure. To solve this problem, multivariate analyses on the relationship between male factors and in vitro fertilization rate were performed, and a nomogram for prediction of LFR was constructed.
Methods This retrospective study contained 2,011 couples who received IVF treatment from January 2017 to December 2021. Man clinical characteristics, laboratory test results, in vitro fertilization rate were collected.
Results A total of 2,011 couples underwent IVF were analyzed. Among these couples, 1,347 cases had in vitro fertilization rates ≥ 30% (control group), and 664 cases had in vitro fertilization rates < 30% (low fertilization rate (LFR) group). Univariate analyses of male factors found that between the two groups there were significant differences (p<0.05) in sperm progressive motility (SPR), sperm concentration (SC), total sperm number, normal sperm morphology rate (NSMR), DFI, sperm acrosin activity (SAA) and the clinical diagnosis of primary or secondary infertility, but not in blood glucose level, MBI, and semen volume. Multivariate logistic regression analyses showed that SPR, SAA, and SC were independent risk factors for LFR. An algorithm and a corespondent nomogram for predicting high LFR risk were constructed using data from the training cohort. The LFR nomogram exhibited an excellent discrimination power and a high fitting degree in both the training cohort (AUC = 0.90, 95% CI: 0.88 - 0.92), (H-L: x2 = 5.43, p = 0.71) and validation cohort (AUC = 0.89, 95% CI:0.87 - 0.92), (H-L: x2 = 7.85, p = 0.45), respectively. The decision curve analysis (DCA) demonstrated a high efficiency of the LFR nomogram for clinical utility.
Conclusions SPR, SAA, and SC are independent risk factors for LFR. The LFR nomogram established based on these factors could be a useful tool to predict high risk of LFR, and patients with high risk of LFR can be guided to direct ICSI procedure. Clinical application of the LFR nomogram may increase the in vitro fertilization rate by facilitating the decision making in IVF service.
User experiences during the transition to calibration-free sensors with remote monitoring while using automated insulin delivery - a qualitative study.
Authors: Sehgal Shekhar , De Bock Martin , Jones Shirley , Frewen Carla , Wheeler Benjamin J 
Published: April 2023

AbstractAim:To evaluate the experiences of patients with type 1 diabetes following transition from a calibration-requiring to a calibration-free sensor and remote monitoring in the context of using automated insulin delivery (AID).Methods:Fifteen participants aged 7–65 years with type 1 diabetes participating in a longitudinal study used a Medtronic® advanced hybrid closed loop (AHCL) device with initially calibration-requiring then calibration-free sensors. Qualitative interviews were conducted ≥20 weeks following use of the calibration-requiring and ≥4 weeks after use of the calibration-free sensors/remote monitoring. Thematic analysis was used to identify key themes and subthemes.Results:At baseline, mean diabetes duration was 14.5 years (±10.9), mean Hba1c 54.8 mmol/mol (±10.2) (7.2±0.9%) and Time in range 75.4% (±11.6).Participants reported a progressive improvement in digital and lifestyle integration, and device trust following transition to calibration-free sensors with remote monitoring potential. They also reported a reduced need for capillary glucose, increased device satisfaction and trust, and reduced burden of diabetes care. Negative aspects reported included periodic early sensor loss, and for some, impaired integration with mobile devices.Conclusion:Transitioning to calibration-free sensors with remote monitoring while using AID was associated with better user experience, including perceptions of improved quality of life and a reduced burden of diabetes care. Appropriate expectation setting, training, and ongoing support allow for the optimal user experience while using AID.
Defying Age: can active older adults with sarcopenic obesity overcome muscle strength and physical performance losses?
Authors: Silva Leonardo Santos Lopes da , Abdalla Pedro Pugliesi , Marcos-Pardo Pablo Jorge , Romo‑Perez Vicente , Garcia‑Soidan Jose Luis , Mota Jorge , Machado Dalmo Roberto Lopes 
Published: April 2023

Abstract
Background: Sarcopenic obesity (SO) is a condition characterized by a combination of low muscle mass and high body fat. It has been associated with reduced muscle strength and physical performance in older adults. However, it is not clear whether even sufficiently active older adults with SO may experience a decline in these outcomes. This study aimed to investigate the associations of SO with muscle strength and physical performance in sufficiently active older adults.Methods: We analyzed data from 72 older obese adults classified as sufficiently active based on their physical activity levels. Participants were categorized into four groups based on sex and SO status. Muscle strength parameters (knee extension using an isokinetic dynamometer, knee extension at an extensor chair, and handgrip strength) and mobility performance tests (six-minute walking distance, time up and go, and gait speed) were compared between groups using independent sample t-tests. Multiple linear regression and binary logistic regression were performed to examine the associations between SO and muscle strength and physical performance variability, adjusting for confounding variables.Results: The prevalence of SO in our sample was 55.6%. Handgrip strength was the only parameter that showed differences between SO groups, regardless of sex (p < 0.05). The six-minute walking distance test showed differences only between men. Multiple linear regression showed that SO negatively explained the variability of handgrip strength (model 2: ꞵ=-0.210; p < 0.05), even when adjusted for confounding variables. Binary logistic regression showed that an increase in handgrip strength values was associated with a decrease in the chances of older adults being classified as SO (OR: 0.784 [95% CI: 0.654–0.940; p < 0.05]), even when adjusted for confounding variables.Conclusion: Our findings suggest that even with SO, sufficiently active older adults did not present a significant reduction in muscle strength in the lower limbs and physical performance. These results highlight the importance of promoting physical activity in older adults with SO to maintain their muscle strength and physical performance.
Investigating the Effects of Fly Ash on the Microstructure and Properties of Aluminium Composites using Taguchi Method
Authors: Palanichamy Ragunath , Lakshmipathy Jayakumar 
Published: April 2023

Abstract
This study aims to investigate the effect of fly ash addition on the mechanical and tribological properties of Al 1100 alloy. Fly ash, a waste by-product from automobile rubbers, was added to Al 1100 at different weight percentages. This study investigates the effect of fly ash content and sintering temperature on the mechanical properties and wear behavior of Al 1100-fly ash composites using the Taguchi method. The composites were fabricated through powder metallurgy, with fly ash content ranging from 0–15% and sintering temperature varied between 500°C and 700°C. Tensile and hardness tests were carried out, and the wear behavior was evaluated using the pin-on-disk method. The results showed that the addition of fly ash significantly improved the hardness of the composites. The highest hardness was observed at 9–10% fly ash content and sintering temperature of 600°C. The tensile strength of the composites was also enhanced with the addition of fly ash. The highest tensile strength was observed at 9% fly ash content and a sintering temperature of 650°C. The wear behavior of the composites was evaluated using the Taguchi method, and the results showed that fly ash content had the most significant effect on the wear resistance of the composites. The wear resistance improved with increasing fly ash content, with the highest wear resistance observed at 9% fly ash content and a sintering temperature of 700°C. The Taguchi method identified the optimal process parameters to obtain the best combination of mechanical and tribological properties. The present study demonstrates the potential of fly ash as a low-cost and sustainable reinforcement material for Al 1100 alloy. In conclusion, the Taguchi method was an effective tool for optimizing the mechanical properties and wear behavior of Al 1100-fly ash composites. The results suggest that fly ash can be used as a reinforcement in Al 1100 to enhance its mechanical properties and wear resistance, making it a promising material for various industrial application.
HNRNPLL is a Prognostic Biomarker Associated with Hepatocellular Carcinoma Immune Infiltration and Related to Migration of Hepatocellular Carcinoma Cells
Authors: Mo Jiajie , Wang Xiaowu , Xu Liming , Chen Mengtao , Zhang Qiyu 
Published: April 2023

Abstract
Background
Heterogeneous nuclear ribonucleoprotein L-like (HNRNPLL) have a critical role in colorectal cancer progression and development. Althouh, the functions of HNRNPLLin liver hepatocellular carcinoma (LIHC) remain unclear.
Methods
Data from three databases, namely, Gene Expression Omnibus (GEO), The Cancer Genome Atlas (TCGA), and International Cancer Genome Consortium (ICGC), as well as tissue microarray (TMA) data were used to investigate the correlation of HNRNPLL expression, clinical features, and prognosis. The Tumor Immune Single-cell Hub (TISCH) website was utilized to examine the relationship between various HNRNPLLmethylation sites and LIHC prognosis and clinical features. CIBERSORT and quanTIseq were used to quantify the immune infiltration level in LIHC. Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis, Gene Ontology (GO) analysis, and gene set enrichment analysis (GSEA) were used to predict the gene function of HNRNPLL. Least absolute shrinkage and selection operator (LASSO) were utilized to construct a prognostic model. Eventually, the impact of HNRNPLL on migration and cell cycle were validated in two hepatocellular carcinoma cell lines, namely, Huh7 and HepG2, using scratch and flow cytometry.
Results
The findings indicated that highest levels of HNRNPLL mRNA and high levels of methylation were significantly connected to lower clinical stage and prognosis. The HNRNPLL expression was significantly positively associated with a variety of immune cells, especially regulatory T cells (Tregs), and the methylation of HNRNPLL was significantly positively associated with M2 macrophages. Finally, receiver operating characteristic (ROC) and decision curve analysis (DCA) curves verified the predictive model based on a protein interaction network had a good prognostic effect. By inhibiting the expression of HNRNPLL, we confirmed that downregulation of HNRNPLL partially reduced the invasion of Huh7 and HepG2 cells. Further, cell cycle was significantly inhibited by siRNA interference of HNRNPLL.
Conclusion
These findings indicated that HNRNPLL is a potential prognostic marker as its expression is significantly positively correlated with Tregs and its methylation status is significantly positively correlated with M2 macrophages. RNA interferes with its expression and has certain effects on cell cycle, migration and invasion.
Prospective Assessment of Early Developmental Markers and Their Association with Neuropsychological Impairment
Authors: Cainelli Elisa , Vedovelli Luca , Trevisanuto Daniele , Suppiej Agnese , Bisiacchi Patrizia 
Published: April 2023

Abstract
Purpose Children who experience adversities in the pre-perinatal period are at a higher risk of developing impairments later in life, despite the absence of overt brain and neurological abnormalities. However, many of these children exhibit sequelae several years after a period of normal appearance. As a result, accurate developmental assessments for the early detection of infants at high risk of adverse neurodevelopmental outcomes have become a significant concern. The Griffiths Mental Developmental Scales (GMDS) have a promising but poorly explored prognostic ability.Methods This longitudinal study evaluated the predictive power of the GMDS at 12 and 24 months on the cognitive and neuropsychological profile at 6 years of age in a sample of 70 children with a history of prematurity or perinatal asphyxia but without brain and neurological abnormalities.Results We found that the GMDS at 24 months had good predictive ability on the IQ at 6 years and the capacity to predict some neuropsychological performances. On the other hand, the GMDS at 12 months was not associated with the performance at 6 years or with the GMDS at 24 months.Conclusions Data on brain development converge to indicate that 2 years of age is a critical stage of development, particularly for children experiencing mild pre-perinatal adversities who are thought to exhibit white matter dysmaturity. For this reason, this age is crucial for identifying which children are at major risk, leaving enough time to intervene before overt deficits become apparent.
Terminology of e-Oral Health: Consensus Report of the IADR's e-Oral Health Network Terminology Task Force
Authors: Marino Rodrigo , Uribe Sergio , Chen Rebecca , Schwendicke Falk , Giraudeau Nicolas , Scheerman Janneke 
Published: April 2023

Abstract
Objective: The International Association of Dental Research e-Oral Health Network (e-OHN) aimed to establish a consensus on terminology related to digital technologies used in oral healthcare.
Method:
The consensus process was comprised of four main stages.First, the task force created a list of terms and definitions around digital health technologies based on the literature and established a panel of experts. Second, email-based consultations and online meetings were organized with the panel of experts to confirm an initial set of terms. Third, this list of terms was presented at the IADR annual meeting to refine the list based on experts’ comments. Fourth, to reach consensus, the taskforce used group discussion and crowdsourcing, to solicit expert opinion about the terminology. A Delphi-questionnaire was sent online to all experts to ask their opinion about the terms and their definitions.
Results: The study led to the identification of an initial set of 43 terms. The list of initial terms was refined to a core set of 37. Thirty-four experts took part in the consensus process about terms and definitions. From them, 27 experts completed the first rounds of consultations, and 14 the final round of consultations. All terms and definitions were confirmed via online voting (i.e., achieving above the agreed 70% threshold), which suggest their agreed recommendation for use in e-oral health research, dental public health, and clinical practice.
Conclusion: This is the first study in oral health organised to achieve consensus in e-oral health terminology. This terminology is presented as a resource for interested parties to be used. These terms were also conceptualised to fit with a new healthcare ecosystem and the place of e-oral health within it.
Comparison of emergency and consulting physicians’ perspective on emergency room consultation
Authors: Limapichat Thanya , SuvithyasiriLimapichat Thanawat 
Published: April 2023

Abstract
Purpose: Effective consultation in the emergency room (ER) improves patient outcomes and reduces the burden on the healthcare system. One of the most serious issues that arises during consultations is the behavior of physicians and their ineffective processes. However, no research has been conducted to compare the perspectives of the physicians as well as the psychological effects during consultation. The primary outcome was the ER consultation process from the perspective of emergency and consulting physicians. The secondary outcomes were inappropriate behavior and its effect on emergency physicians’ (EPs) mental health.
Methods: This study included emergency and consultant physicians from nine departments. Participants (N = 144, 115 consulting physicians and 29 EPs) completed questionnaires that included items about Chad Kessler’s 5-C model (contact, communication, core question, collaboration, and closing the loop) and emergency and consultants’ behavior or problems. Data were collected from February 2022 to June 2022.
Results: Most of the steps in the 5-C model had a mean score higher than 7.0. There were significant differences (p < .05) in all domains of Kessler’s 5-C model when comparing the perspectives on EPs’ behavior between the two groups. Disrespectful behavior was the most common inappropriate behavior among the consulting physicians. The most inappropriate behaviors of EPs were “an EP could not be found bedside” and “consulting about a condition that could be managed as an outpatient.” EPs believed that being “concerned about consulting with the same physician in the future” was the top psychological effect, with a mean (SD) of 4.7 (2.7).
Conclusions: Physicians agreed that Kessler’s 5-C model can lead to effective consultation and conflict reduction. Including this model in residency-training program is recommended. Physicians should improve their communication skills and avoid disrespectful behavior.
MSC-derived exosomes protect auditory hair cells from neomycin-induced damage via autophagy regulation
Authors: Liu Huan , Kuang Huijuan , Wang Yiru , Bao Lili , Cao Wanxin , Yu Lu , Qi Meihao , Wang Renfeng , Yang Xiaoshan , Ding Feng , Ren Lili , Ye Qingyuan , Liu Siying , Ma Furong , Liu Shiyu 
Published: April 2023

AbstractIncreasing incidence of sensorineural hearing loss (SNHL) has raised concerns over the disease, while the limited treatment options have motivated the study of new biological therapies. Among these, mesenchymal stem cell (MSC) transplantation has been shown to improve hearing function, and accumulating evidence indicates that MSCs could impart their therapeutic effects by secreting exosomes. However, the underlying therapeutic mechanisms are not fully understood. Herein, in a neomycin-induced SNHL model, we found that exosomes released by MSCs rescued hearing loss and ameliorated hair cell loss by regulating autophagy of the recipient hair cells. Mechanistically, exogenous exosomes could be engulfed by hair cells after treatment. Then, in the hair cells, exosomes promoted the expression of endocytic genes and the formation of endosomes, thus inducing autophagy activation. Finally, the enhanced autophagy promoted cell survival, reduced mitochondrial oxidative stress and apoptosis of hair cells, and attenuated neomycin-induced ototoxic damage. Collectively, our study unveiled the otoprotective role of autophagy activated by exogenous exosomes in hair cells, and verified the potential of extracellular vesicle-based biological therapy for SNHL caused by neomycin.