bluuebunny/crossref_metadata_2025_split huggingface dataset:
A comparative analysis of road and vehicle qualities as factors of road traffic carnage in Nigeria
Authors: Eneh Chinemelum A. , Okosun Andy , Oloto Martin C. , Emenuga Veronica , Ehiogu Chizoba P. , Eneonwo Cosmas I. , Eneh Onyenekenwa C. 
Published: December 2022

Abstract
Background and Objective: Carnage on roads is a growing concern in Nigeria. Over 27 persons, equivalent to more than 4 families, die daily from road traffic crashes. Two direct factors of a road crash are road quality and vehicle quality. To interrogate and compare both factors to road traffic accidents, the longitudinal study regressed secondary data on death tolls against road quality and vehicle quality.
Materials and Methods: Data on the estimated number of vehicles imported into Nigeria (1992-2021) served as the indicator of vehicle quality on Nigerian roads. The longitudinal study regressed secondary data on death tolls (2013-2019) against road quality (2006-2019) and vehicle quality (1992-2021).
Results: Results showed that road quality is degenerating as well as vehicle quality in Nigeria, resulting in increases in the number of road traffic crashes and the attendant death tolls. For every 1% decrease in road quality, death tolls from road traffic crashes in Nigeria increased by 0.00642% at 5% significance, and for every decrease in vehicle quality, death tolls from road traffic crashes in Nigeria increased by 0.327% at 5% significance.
Conclusion: The study recommended increased advocacy on the sanctity of life and the need for the federal, state and local governments to prioritize policy and implementation of improving the road quality and vehicle quality to reduce road traffic crashes and save lives on Nigerian roads.
Modelling the electricity mix for Togo by 2050 using OSeMOSYS
Authors: Tchandao Esso-Wazam Honoré 
Published: December 2022

Abstract
This work uses bottom-up modeling to explore the future evolution trajectories of the electricity mix in Togo by 2050. The objective is to investigate the evolution of the mix and the future investments needed to achieve the sustainable energy and climate change goals. Three scenarios were developed using OSeMOSYS. The reference scenario, named Business As Usual, closely reflects the evolution of the Togolese electricity sector under a business-as-usual assumption and planned capacity increases up to 2030. The second scenario, Net Zero by 2050, is based on the first scenario while ensuring that CO2 emissions cancel out in 2050 by following the Weibull law. The third scenario called Emission Penalty aims not only at the integration of renewable energies like the second one but also at the least cost electricity mix if emission penalties are applied. The results of the cost optimization indicate that photovoltaic and importation are the optimal choices ahead of gas and hydropower. The renewable energy aspect of the electricity mix is more highlighted in the last scenario. At the same time, the model shows that greater energy independence is achievable at the cost of a transitory increase in the cost of the electricity system. A tenfold investment effort is needed in 2030 to ensure either continuity of the status quo or a shift in strategy.
Reprogramming of transcriptome after hormetic heat stress by the endoribonuclease ENDU‑2 improves lifespan and stress resistance in C. elegans
Authors: Xu Fan , Gromoff Erika D v. , Drepper Friedel , Knapp Bettina , Warscheid Bettina , Baumeister Ralf , Qi Wenjing 
Published: December 2022

Abstract
Any organism is constantly exposed to dangerous, potentially life-threatening environmental impacts that demand coordinated responses. Although acute stress responses as temporal reactions to unfavorable external or internal factors are well known, transient stress experiences may have long-term physiological consequences. The underlying mechanisms adjusting cellular activities across time scale is poorly understood. Here, we investigate the long-term alteration of C. elegans transcriptome after a short heat shock (HS) exposure and discovered that the canonical HS response is followed by a profound transcriptional reprogramming that affects many genes involved in innate immunity response. This transcriptional reprogramming depends on the function of the endoribonuclease ENDU-2 but not the heat shock factor 1 (HSF-1). ENDU-2 in this context co-localizes with chromatin and interacts with RNA polymerase Pol II to specifically regulate transcription in the post-HS period. Failure to activate this post-HS response does not impair survival of animals upon HS insult, but abolishes the hormetic HS mediated beneficial effects. In summary, our work discovers that the hormetic long-term effects of a transient HS are mediated by the RNA-binding protein ENDU-2 that determines aging and longevity.
Analysis of the ankle joint fixation methods in patients with failed treatment outcomes of distal tibia injuries and their consequences
Authors: Grazhdanov Konstantin A. , Zuev Pavel P. , Baratov Andrey V. , Sertakova Anastasiya V. , Rubashkin Sergey A. , Norkin Igor A. 
Published: December 2022

Abstract
We analyzed the treatment outcomes of distal tibia injuries and their consequences in 144 patients with terminal stages of post-traumatic ankle osteoarthritis. The research employed clinical and radiological methods as well as the Foot Function Index questionnaire. Surgical methods involved ankle arthrodesis and various combinations of grafts and fixators. It has been established that osteoplastic arthrodesis during as a part of surgical rehabilitation in patients with the consequences of ankle injuries complicated by the terminal arthrosis ensures a complete restoration of the support function in the injured lower limb as well as pain relief.
psycho-social stressors among hepatitis C virus patients and its relationship to anxiety, depression and adjustment
Authors: Haggag Abdelmotaleb Abdelkader 
Published: December 2022

Abstract
Background
This research aimed to identify psycho-social stressors among hepatitis C virus patients and its relationship to anxiety, depression and adjustment. An Internet-based cross-sectional study was conducted where the available sample was selected from 379 HCV patients and another uninfected sample consisting of 381 respondents, bringing the total to approximately 760 respondents between January 4 and October 28, 2021. Participants completed four self-reported scales. The scales included the psychosocial stressors of patients scale (PSPS), Beck depression inventory (BDI-I), the state-trait anxiety inventory (STAI) and general adjustment scale (GAS).
Results
The results reveal that there are differences between patients with HCV-positive, patients with HCV-negative and healthy people in the psychosocial stressors in favor of patients with HCV-positive. There was a positive correlation between psycho-social stressors of hepatitis C patients with anxiety, depression, adjustment and age. There were differences between patients with HCV and healthy people in the following variables: anxiety, depression, healthy adjustment, family adjustment, professional adjustment, social adjustment and general adjustment in favor of patients with HCV. There were differences between patients with HCV-positive and patients with HCV-negative in the following variables: anxiety, depression, healthy adjustment, family adjustment, social adjustment and general adjustment in favor of patients with HCV-positive.
Conclusions
This study recommended that care must be taken in the counseling and psychotherapy of HCV patients to reduce the mental disorders associated with the disease.
Asymmetry Behaviour of Real Exchange Rate Volatility and Trade Flows: a Bilateral Analysis
Authors: OLUBIYI Ebenezer , BIALA Musa 
Published: December 2022

Abstract
The debate on the effects of exchange rate volatility on trade is still ongoing. This study however focuses on how asymmetry behaviour in bilateral exchange rate influences trade between Nigeria and five of its major trading partners, namely France, US, Netherland, China and India. Data on relevant variables are obtained on monthly basis over the period of 2011:4 to 2020:12. Time varying variance (generalized autoregressive conditional heteroskedasticity – GARCH) is employed to generate the volatility series while nonlinear autoregressive distributed lag (NARDL) in the context of expected utility theory was employed. The NARDL results suggest that there exists both short and long run asymmetry behaviour of most of the bilateral real exchange rates. Specifically, positive change in bilateral real exchange rate volatility enhances exports to all the trading partners except US. Negative change in bilateral real exchange rate volatility facilitates exports to China, India and the US but inhibits exports to France and Netherland. The magnitude of positive change is stronger than the negative change in this regard. Both positive and negative change in bilateral real exchange rate volatility reduces imports from all the trading partners except from India. Following these results, some policy implications and recommendations are drawn. One of such recommendations is that the monetary authorities in Nigeria should expand the number of foreign currency in the basket for settling international transactions. In this regard, Yuan and Rupee are recommended to also be part of the major currencies.
JEL Classification: F14, F31, F41
Política educacional para o Ensino Médio
Authors: Mota Érico Ricard Lima Cavalcante , Casagrande Ana Lara , Alonso Katia Morosov 
Published: December 2022

As políticas educacionais direcionadas ao Ensino Médio têm incorporado a educação em tempo integral como forma de alinhá-la às tendências contemporâneas. Logo, a configuração desta etapa de ensino se constitui como disputa ideológica por agendas políticas dicotômicas: demanda produtiva versus formação omnilateral dos jovens. O Estado do Mato Grosso implantou seu projeto de Ensino Médio em tempo integral em “Escolas Plenas”, trazendo singularidades organizacionais, metodológicas e curriculares. Neste trabalho, buscou-se analisar suas configurações na dimensão da política educacional e do projeto pedagógico materializado. Metodologicamente, foi realizado um estudo de caso em uma escola pública de Cuiabá, que revelou uma perspectiva gerencialista, assentada na defesa de um protagonismo nebuloso em face da noção de empresariamento de si mesmo e auto responsabilização do estudante sobre seu percurso, apagando as condições extraescolares implicadas. De maneira que se questiona essa reestruturação do Ensino Médio frente à efetiva materialização da democratização da Educação.
In-Silico Study of Resveratrol as Multi-Edged Potent Inhibitor against SARS-Cov-2 and Variants of Concern Using Molecular Dynamic Simulation and PCA Analysis
Authors: Kumar Sahoo Amaresh , Singh Vishal , Agarwal Vidhu , Varadwaj Pritish Kumar 
Published: December 2022

Background:
Novel Coronavirus infection was announced as a global pandemic by the World Health Organization owing to its high spread and pathogenicity. In due course, there are a few approved drug molecules available for the treatment of SARS-CoV-2 infections, and a few more drugs are in the pipeline of clinical trials. However, a recent challenge has come up with rapid mutations on several proteins including the S protein of SARS-CoV-2. Multi-targeted (polypharmacological) therapy may be an effective strategy for the treatment of SARS-CoV-2 and its emerging variants.

Objectives:
In this study, we performed structure and pharmacophore-based screening by considering more than 12,000 compounds from FDA-approved drugs, antiviral drugs, anticancer drugs, and bioactive molecules from spices, vegetables, and fruits against the main protease (Mpro) enzyme of SARS-CoV-2.

Methods:
Virtual screening was performed by molecular docking. Furthermore, the best-selected molecule resveratrol was rescreened and subjected to docking, MMGBSA, molecular dynamic simulation, and principle component analysis (PCA) with 09 more essential (normal) target proteins and 02 spike variants (Delta / Omicron spike protein in complex with human ACE2) of SARS-CoV-2 to investigate multi-targeting potency of resveratrol.

Results:
Thus, all in-silico studies and their analyses show, resveratrol might serve as a potential multi-targeting molecule. Molecular dynamics simulation of 100 ns substantiated the strong interactions of proteins with resveratrol. The proposed molecule has strong interactions with 07 normal and mutated spike (S-RBD-ACE2) proteins of SARS-CoV-2.

Conclusion:
The present study demonstrated that resveratrol may be useful for polypharmacological therapy against normal/mutated variants of SARS-CoV-2 to address the ongoing pandemic.
The Responses of Rural Learner Nurses to Virtual Learning in a COVID-19 Era
Authors: Mbombi Masenyani Oupa , Muthelo Livhuwani , Phukubye Arthur Thabo 
Published: December 2022

Background:
The COVID-19 pandemic resulted in many universities suspending their academic activities, making virtual learning an option for saving the disrupted academic year. The pandemic presented an opportunity to assess the implementation of virtual learning at this university, thus forcing rural-based universities to enhance their learning management system, including their clinical disciplines. This paper explores the use of virtual learning amongst learner nurses in a rural-based university by following the el-CDDO framework.

Methods:
A quantitative descriptive design was applied to describe the barriers experienced to virtual learning in a rural university. The purposive convenience sampling method was used to select learner nurses from the Faculty of Healthcare Sciences. An electronic survey questionnaire with both open and closed-ended questions sent via WhatsApp messenger was used to collect data. Data were analyzed using descriptive statistics with SPSS version 26.

Results:
The el-CDDO components affected in the study included the Context, Delivery, and Outcomes of virtual learning in a rural-based university. The Context demonstrated geographically disadvantaged learner nurses, which affects virtual learning delivery. Thus, the Outcomes included various barriers to virtual learning, such as weak networks for connecting to Blackboard, the lack of ICT facilities, such as laptops and tablets, by learner nurses, a lack of skills for using Blackboard, and ageing academics.

Conclusion:
The study findings provide a baseline reference for future digital health in the clinical area and the use of virtual learning in a rural-based university. Though we noted complex challenges such as the lack of gadgets, our findings provide a significant contribution to the planning for virtual learning in universities and the use of digital health care in the clinical area. Addressing the virtual learning barriers discussed in this paper will be a significant step in equipping learner nurses with digital knowledge and skills as future healthcare professionals. There is a need to develop strategies to enhance virtual learning in rural-based universities to ensure future digital health.
Prevalensi Bakteri Resisten Karbapenem di RSUP Dr. Sardjito Periode Januari-Agustus 2020
Authors: Primasari Firdhani Satia , Puspitasari Ika , Nuryastuti Titik 
Published: December 2022

Salah satu kasus resistensi yang memerlukan perhatian khusus saat ini adalah resistensi bakteri terhadap antibiotik golongan karbapenem. Adanya resistensi terhadap penggunaan antibiotik karbapenem dan belum ditemukannya antibiotik baru menjadikan cakupan pilihan antibiotik menjadi cukup sulit. Banyak negara telah melaporkan kejadian resistensi bakteri karbapenem dan jumlahnya terus mengalami peningkatan. Di Indonesia, data tersebut masih sangat minim dan belum banyak yang mengkaji. Penelitian ini bertujuan untuk mengetahui besarnya prevalensi dari tiga macam bakteri, yaitu Pseudomonas aeruginosa, Acinetobacter baumannii, dan Enterobacterales spp yang resisten terhadap antibiotik karbapenem. Penelitian ini merupakan penelitian observasional retrospektif yang mengambil data hasil uji sensitivitas isolat Pseudomonas aeruginosa, Acinetobacter baumannii, dan Enterobacterales (Klebsiella pneumoniae dan Escherichia coli) periode Januari-Agustus 2020. Prevalensi dihitung dengan membandingkan jumlah bakteri yang resisten karbapenem terhadap total isolat bakteri yang ada. Dari hasil perhitungan, diperoleh bahwa prevalensi dari ketiga macam bakteri tersebut fluktuatif tiap bulannya. Di mana didapatkan pola bahwa antara bulan April-Mei prevalensi ketiga bakteri resisten karbapenem tersebut mengalami penunurunan kemudian untuk mengalami peningkatan untuk Pseudomonas aeruginosa dan Acinetobacter baumannii. Prevalensi bakteri resisten karbapenem tertinggi ditemukan pada Acinetobacter baumannii dengan rentang prevalensi antara 46,43%-70%, diikuti Pseudomonas aeruginosa dengan prevalensi sebesar 12,82%-23,33%, dan Enterobacterales dengan prevalensi 0,73%-8,24%.
Empowering Modern Kartinis to Welcome Industry 4.0 through an E-Commerce Workshop
Authors: Sari Wina Permana , Sidharta Hanugra Aulia , Sidharta Sidharta 
Published: December 2022

Most Indonesians have a strong view that a woman should stay at home and refrain themselves from having a job. These days as technology makes life easier, this view has been shifting. Women are able to work, even from home. Furthermore, during the COVID19 pandemic, the role of women in helping the family’s economy was greatly inﬂuential. During this pandemic, quite a lot of people have been laid oﬀ due to the government enforcing social distancing policy, which aﬀects companies because customers prefer to stay at home and follow the government’s requests. Due to this situation, the authors provide a solution for Indonesian Kartinis, especially the PKK women in Purwodadi Village, City of Malang who mostly have small businesses, such as making traditional kue basah, tailors, and other crafting businesses. They were forced to stop their businesses in this pandemic, and one of the factors was because they could not utilize advanced technology and market their product online. The solution for this issue is giving guidance and e-commerce training for the PKK women using the Asset Based Community Development (ABCD) method, so E-Commerce in every business will be sustainable and the results of increasing knowledge of this E-Commerce workshop are 83%.
Evaluación de Chlorophytas como indicadoras de contaminación por metales pesados en el litoral sur de Santo Domingo
Authors: Meléndeza Elvis Nicolás 
Published: December 2022

Las Chlorophytas han sido utilizadas en estudios de contaminación en metales pesados anteriormente. Estas algas tienen la capacidad de acumularse en grandes alfombras de talos que flotan y se adhieren en las rocas intermareales y costeras. Los metales pesados son sustancias que pueden ser tóxicas en bajas concentraciones. Existen métodos para la detección de estos metales como la Espectroscopia de Absorción Atómica (EAA). Esta metodología se puede utilizar con organismos que adsorben estos metales como, por ejemplo, las macroalgas. Se identificaron Ulva fasciata y Chaetomorpha gracilis, las cuales se acumulan en el litoral sur de Santo Domingo. Para buscar una forma natural de detección para la acumulación de este material biológico contaminante, U. fasciata y C. gracilis fueron evaluadas para ser consideradas como bioindicadores de contaminación por metales pesados. Se obtuvieron concentraciones promedio en U. fasciata para el cobre de 15.968 mg/kg, para el hierro de 102.985 mg/kg y para el cinc de 63.598 mg/kg. En C. gracilis, para el cobre de 62.207 mg/kg, para el hierro de 2426.081 mg/kg y para el cinc de 97.555 mg/kg. Se pudo evaluar que la división Chlorophyta sí puede ser bioindicador de metales pesados en el litoral sur de Santo Domingo, República Dominicana.
The influence of shaping on the behavior of a mesh shell shaped as a one-sheeted hyperboloid
Authors: Nechiporuk Gennady S. , Pravdolyubova Svetlana S. , Vekilyan Mikhail O. 
Published: December 2022

Introduction. The stress-strain state (SSS) of mesh shells that have the shape of a one-sheeted hyperboloid, consisting of one, two and three sections and subjected to vertical and wind loads coupled with their own weight is studied. The feature of these shells is the use of the Fibonacci number in their geometry, or in the ratio of their diameters and heights.
Materials and methods. The position of rectilinear generatrices of shell depends on the angle of inclination of generatrices, which is determined by the mutual rotation of the upper and lower bases, and it determines various shapes of the structure. The stress-stain state of shells is found numerically using the LIRA–SAPR software package. The largest forces arising in the generatrices and the largest horizontal displacements of the upper edge of the shell, caused by wind loading, are compared.
Results. Equations are obtained to identify the position of the generatrix and the size of the real semi-axis of the hyperboloid. Analytical models of shells with different inclinations of generatrices are provided. As a result of the data analysis, the shapes of shells, having different heights and numbers of storeys, are proposed to ensure their optimal strength and stiffness. If the structure is subjected to vertical loads and self-weight, the mutual rotation of upper and lower bases does not affect the SSS of e shells. When the wind load is applied, the situation is completely different. Hence, for single-section shells of medium height and high shells with optimal parameters of internal forces and displacements, the size of the real semi-axis coincides with the size corresponding to the “golden section”. At the same time, shells with a small angle of mutual rotation of the bases barely resist lateral loading. In two- and three-sectional shells, the value of the real half-axis is slightly greater.
Conclusions. The use of mesh shells, having the shape of a one-sheeted hyperboloid that has the “golden section” ratio, allows obtaining more expressive structural solutions. Analytical models of such structures are presented.