bluuebunny/crossref_metadata_2025_split huggingface dataset:
MiRNA-219a-1-3p inhibits the malignant progression of gastric cancer and is regulated by DNA methylation
Authors: Luo Min , Tang Jian , Zhu Ying , Wu Liping , Fu Hu , Zhang Fan , Li Hongxia , Qing Keqin 
Published: May 2023

Abstract

Objective
Worldwide, gastric cancer (GC) is one of primary reasons for cancer-related deaths. However, the pathogenic mechanism underlying GC remains to be fully understood. MicroRNAs are momentous regulators of diverse biological progression in cancer. Even though the ability of miR-219a-1-3p to inhibit malignant progression in pancreatic cancer have been previously reported, its role in GC remains to be elucidated.

Methods
Quantitative real-time PCR (qRT-PCR) was performed to measure miR-219a-1-3p expression levels in collected GC samples (n=98) and paired nearby non-tumor tissues. Cell proliferation, migration, and invasion assays were then conducted to explain the biological influences of miR-219a-1-3p in vitro. In vivo effects were confirmed by subcutaneously injecting miR-219a-1-3p overexpressing MGC-803 cells into nude mice. Methylation-specific PCR was employed to evaluate the CpG island upstream methylation condition of miR-219a-1-3p in collected clinical tissues (n=22), GC cell lines and GES-1 cells. GC cells were supplemented with 5-aza-2′-deoxycytidine to identify the miR-219a-1-3p expression changes using qRT-PCR.

Results
The miR-219a-1-3p expression was obviously suppressed in GC tissues relation to nearby non-tumor tissues, along with in GC cell lines in comparison to GES-1. Moreover, in vivo and in vitro functional evaluations indicated the function of miR-219a-1-3p in inhibiting the malignant characteristics of GC cells. Mechanistically, MiR-219a-1-3p expression was partly regulated utilizing DNA hypermethylation in GCs. In addition, overexpression of miR-219a-1-3p inhibited PI3K/AKT signaling.

Conclusions
MiR-219a-1-3p might function as a tumor suppressor in GC, and our investigation creates a foundation to diagnose of GC.
HOMENAGEM À PIANISTA E POETISA YARA CAVA
Authors: Cava de Oliveira Sônia André , Franco de Souza Clarice 
Published: May 2023

Este artigo tem como objetivo apresentar algumas vivências e produções artístico-culturais da Professora, Pianista e Poetisa Yara Cava. Abordamos sua iniciação ao aprendizado da música através do piano; os estudos realizados até sua formatura pelo Conservatório de Música de Pelotas, bem como sua trajetória como docente dos cursos de Licenciatura, Bacharelado e Pós-Graduação em Música da UFPel. Passamos por algumas realizações artístico-musicais de relevância por ela realizadas. E por fim, suas vivências no campo da poesia, bem como a abordagem de sua produção literária.Palavras-chave: Professora; Pianista; Poetisa; Vivências. HOMENAGE AL PIANISTA Y POETISA YARA CAVA Resumen: Este artículo tiene como objetivo presentar algunas experiencias y pro­ducciones artístico-culturales de la maestra, pianista y poeta Yara Cava. Nos acer­camos a tu iniciación para aprender música a través del piano; los estudios realiza­dos hasta su graduación por el Conservatorio de Música de Pelotas, así como su trayectoria como docente en los cursos de pregrado y posgrado en Música de la UFPel. Pasamos por algunos logros artísticos musicales de relevancia realizados por ella. Finalmente, sus experiencias en el campo de la poesía, así como el enfo­que de su producción literaria.Palabras clave: Maestra; Pianista; Poeta; Experiencias.
PRECISAMOS FALAR SOBRE O CATIVEIRO DAS MULHERES: A FIGURA DA MÃESPOSA COMO UM MODELO DE APRISIONAMENTO NO AUDIOVISUAL
Authors: Penkala Ana Paula , Ebersol Isadora 
Published: May 2023

Este trabalho discute a representação da mulher no audiovisual a partir do conceito de mãesposa desenvolvido por Marcela Lagarde (2005) e alicerçado na noção da mulher cativa, aprisionada na sua condição feminina. A figura da mãe e da maternidade é pensada em seu aspecto literal e alegórico centrada na personagem Eva do filme Precisamos falar sobre o Kevin (We need to talk about Kevin, Lynne Ramsay, 2011), que é mãe do jovem autor de um massacre em sua escola. A jornada de culpa e penitência da personagem tematiza questões sociais, culturais e psíquicas relacionadas à socialização feminina para o cativeiro da maternidade e da conjugalidade.Palavras-chave: Mãesposa; Representação; Cativeiros; Alegoria; Maternidade. WE NEED TO TALK ABOUT WOMEN’S CONFINEMENT: THE MOTHER/WIFE CHARACTER AS A MODEL OF IMPRISIONMENT IN AN AUDIOVISUAL PRODUCTION Abstract: This paper discusses the representation of women in film, based on the concept of mothers/wives developed by Marcela Lagarde (2005) and built on the notion of the captive woman, imprisoned in her female condition. Literal and allegorical aspects of mother and motherhood figures are discussed, centering on the character of Eva, who is the mother of a young perpetrator of a mass shooting at a school in the movie We need to talk about Kevin (Lynne Ramsay, 2011). The journey into Eva's guilt and penance is the theme for bringing up social, cultural, and psychological issues related to the socializa­tion of women and the relationship between captivity, motherhood and marriage.Keywords: Mothers/wives. Representation. Captivity. Allegory. Motherhood.
AS OTRAS
Authors: Rivera Luque Fernanda , Shock Susy 
Published: May 2023

Resumem: Ensayo visual y poético con la poesía Las otras de la artista argentina Susy Shock y fotografías de la artista Fernanda Rivera.Palabras clave: Fotografía, os otros. AS OUTRAS Resumo: Ensaio visual e poética com a poesia Las otras de artista argentina Susy Shock e fotografias de artista Fernanda Rivera. Palavras-chave: Fotografia, as outras. THE OTHERSAbstract: Visual and poetic essay with the poem The others by argentine actress Susy Shock and photographs by argentine artist Fernanda Rivera. Keyswords: Photography, the others.
Maquinações Poéticas: uma aula, uma pesquisa, uma vida
Authors: Albernaz de Araujo Róger 
Published: May 2023

Este artigo ensaia compor uma poética dos percursos da aula, da pesquisa e da vida. Tensiona, com Gilles Deleuze e Félix Guattari, o que passa e o que pode vir a passar entre essas relações. Questiona como são produzidas as sínteses de verdade e como são instituídos os conteúdos e as expressões em um determinado meio. Problematiza, com o Método Maquinatório, modos e ritmos possíveis de maquinar e de fabular deslocamentos e perspectivas: ora um meio, ora um modo, ora um ritmo. E, o que passou?Palavras-chave: Método Maquinatório; Poética, Vida; Pesquisa; Aula. Poetic Machinations: a class, research, a lifeAbstract: This article attempts to compose a poetic about the pathways of the class, research and life. It intensifies, by means of Gilles Deleuze and Félix Guattari, what happens and what may come to pass between their relationships. It questions how the synthesis of truth is produced and how the contents and expressions of a certain subject are instituted. Using the Machinatory Method, it problematizes possible ways and rhythms for machinating and fabulating displacements and perspectives: sometimes through a medium, sometimes a means, sometimes a rhythm. So, what happened?Keywords: Machinatory Method; Poetic; Life; Research; Class.
Alexandre Kojève and Carl Schmitt: the Political, Theology and the End of History
Authors: Jokubaitis Linas 
Published: May 2023

The aim of the article is to demonstrate that Carl Schmitt’s and Alexandre Kojève’s ideas about the political and the end of history have to be seen in the light of their theological presuppositions. The article defends the position that Schmitt’s The Concept of the Political is based on attempts to look at the problems of political anthropology from theological perspective, in which the dogma of original sin plays a central role. Kojève’s anthropotheistic system presents an inversion of this perspective, his ideas about the end of politics and history are inseparable from attempts to reduce theology to anthropology. His atheistic system of immanence provides a confirmation of Schmitt’s idea that the disappearance of the political is incompatible with the dogma of original sin. Kojève’s notion of the end of history and his concept of universal homogeneous state are formed by attempts to look at the concept of the political ex negativo. For Schmitt Christian theology provides a guarantee that the world will not be depoliticized, that enmity between humans will not be overome. French philosopher’s political theory is based on the idea that the end of history and the disappearance of the political would mark the actualisation of secularized Christian teaching. Kojève’s revised ideas about the destiny of humanity at the end of history, his position that humanity will return to animality, have to be understood in the context of his discussions with Schmitt.
A gróf, a festő és a bécsi ágens: Széchényi Antal képmása Michael Christoph Emanuel Hagelganstól (1762)
Authors: Jávor Anna 
Published: May 2023

The half-length portrait of cavalry general Count Antal Széchényi (1714–1767) is kept in the Rómer Flóris Museum of Győr. During its restoration the painter’s signature came to light: Hagelgans pinxit / Wien 1762, and in the Széchényi family archives the correspondence about the picture can be found. Between the painter and the client, the count’s agent in Vienna, Johann Edler von Hermann was the liaison, who claimed that Hagelgans regarded the painting so good that he kept it for himself and made a replica for Antal Széchényi. In the early 20th century the first picture was kept at the Ludovika military academy in Budapest, and the copy ended up in the museum from the family. The Darmstadt painter signed a representative portrait in the Historical Picture Gallery of the Hungarian National Museum in 1758. Later the portrait – including the face – was overpainted and the coat of arms of chief justice Baron Ferenc Koller as well as the middle cross of the Order of St Stephen Koller received in 1765 were added.Agent Hermann also tried to find a fresco painter for Antal Széchényi and consulted Gregorio Guglielmi, who was working on Schönbrunn at that time. He failed to get advice, but he did send a master to Nagycenk, who may have been Johann Ignaz Cimbal. Although no baroque fresco was painted in the Széchenyi mansion, but on the basis of the style of the altar picture of the chapel (Christ on the Cross) and the praedella showing the Virgin Mary suggests that they might hypothetically be attributed to the fertile altarpiece and fresco painter who had settled from Wagstadt (Bílovec) to Vienna.Several Vienna-based agents of Hungarian aristocrats pursued artistic activity and art brokering. Stefan Fabsich and Antal Pruszkay worked for the bishop of Eger Károly Eszterházy, the mentioned Knight Hermann and a certain Heinrich Schwarzenberger and later his widow acquired art works for István Esterházy of Zólyom (Zvolen), who also employed the court agent Johann Stifftel. Between 1758 and 1762 Stifftel was the secretary of the princes Esterházy in Kismarton (Eisenstadt): he arranged for the first contract with the composer Joseph Haydn.
„Megbízottam szoborral hétfőn este indul…” Az egervári Straub-szobrok múzeumba kerülésének és másoltatásának története dokumentumok tükrében
Authors: Boda Zsuzsanna 
Published: May 2023

The rococo wooden statues of St Sebastian and St Roch were purchased by the Museum of Fine Arts in 1916. Earlier they had adorned the high altar of the church of St Catherine of Alexandria in Egervár (Zala county) flanking the tabernacle. Their first researcher, Mária Aggházy attributed them to the Graz sculptor Philipp Jakob Straub (Wiesensteig 1706–Graz 1774). The Egervár church of mediaeval origin belonged after the Ottoman era to the advowson of the Széchényi family who had trade and art relations with Styria, too; they had the church rebuilt and furnished in baroque style in the mid-18th century.As part of the contract of sale, the museum undertook and financed the making of exact copies of the statues to replace the original ones on the high altar, where they still are. It can be reconstructed from the correspondence of 1912–’22 preserved in and Museum of Fine Arts Archives and the Archives of the Diocesan Archives in Szombathely that probably little before 1912 the statues were transferred to the Szombathely episcopacy for conservation. Bishop János Mikes had them restored and maybe also exhibited. Their sale became necessary for the parish to be able to renovate the deteriorating Egervár church. The deal was concluded with an ordinary procedure, but World War I and the inflation it entailed greatly protracted the making of the copies and boosted the costs. Eventually, the replicas were completed in two phases by teachers of the National Royal Hungarian School of Applied Arts, sculptor Sándor Matéka (St Sebastian) and decorator and furniture designer Béla Kajdy (St Roch).
ANALISIS FINANSIAL USAHA PENANGKAPAN IKAN DENGAN PUKAT CINCIN PADA KM. MINA MARITIM 150 WPP 716 Di KABUPATEN GORONTALO UTARA
Authors: Nurfitriana Nia 
Published: May 2023

dan kelautan yang besar. Sektor perikanan dan kelautan merupakan salah satu sektor unggulan yang dijadikan prioritas dalam bidang ekonomi. Sektor ini didukung oleh potensi alamnya berupa garis pantai yang dimiliki cukup panjang ± 320 km. Penelitian ini bertujuan untuk mengetahui seberapa jauh kegiatan penangkapan ikan memberikan keuntungan dan juga layak untuk dikembangkan. Penelitian ini dilakukan dengan menggunakan metode analisis finansial usaha. Data primer dan data sekunder digunakan dalam pengumpulan data penelitian ini. Data primer berupa hasil pengamatan langsung di atas kapal dikumpulkan melalui keikutsertaan dalam kegiatan operasi penangkapan ikan di kapal KM. Mina Maritim 150, sedangkan data sekunder berupa surat – surat kapal, data dari pemilik atau perusahaan penangkapan ikan serta literature-literatur yang dijadikan acuan atau landasan teori. Analisa data dilakukan dengan menggunakan analisis deskriptif dan kuantitatif. yaitu komposisi hasil tangkapan, perhitungan aspek analisis finansial dan produktivitas kapal. Hasil penelitian ini menyatakan bahwa komposisi ikan hasil tangkapan dengan hasil tangkapan utama ialah cakalang 10.750 kg (50%), tongkol 6.850 kg (32%), dan layang 3.970 kg (18%). Hasil analisis menunjukkan bahwa keuntungan finansial yang didapat oleh KM. Mina Maritim 150 adalah laba bersih atau keuntungan pendapatan dalam satu tahun Rp. 608.205.511, masa pengembalian Payback Period (PP) 4 tahun 1 bulan, Revenue Cost Ratio (R/C) sebesar 1,29, Return Of Invesment (ROI) selama satu tahun adalah 24% dan Break Even Point (BEP) hasil tangkapan dalam satu tahun harus mencapai 70.834,68 kg dengan jumlah penjualan harus mencapai Rp. 1.088.110.048. Berdasarkan perhitungan tersebut dapat disimpulkan bahwa usaha tersebut termasuk usaha yang menguntungkan dan layak secara finansial.
Шекспир и русская литература начала XX века. Введение в проблему
Authors: Захаров Николай Владимирович 
Published: May 2023

<p>Статья посвящена осмыслению процессов, связанных с эволюцией литературной репутации Шекспира в Серебряном веке. Изучение творчества Шекспира в русской литературе, литературной критике и литературоведении начала XX в. нуждается в многоуровневом анализе и систематизации.</p><p>Давно назрела необходимость целостного исследования литературного творчества великого английского писателя с учетом его воздействия на театр (режиссерские замыслы, актерское мастерство), музыку, изобразительные искусства. Отечественный шекспиризм является предметом дискуссии и образцом для подражания творцов искусства Серебряного века.</p><p>В статье дан анализ работы русских исследователей и поэтов над изданием Полных собраний сочинений Шекспира на рубеже XIX–ХХ вв. Их публикация сопровождались вступительными статьями, научными комментариями, иллюстрациями на шекспировские темы выдающихся художниками XVIII и XIX столетий. Отмечена особая популярность создания русскими композиторами того времени музыкальных произведений по мотивам поэзии Шекспира (М. А. Балакирев, П. И. Чайковский, С. С. Прокофьев, Д. Д. Шостакович, Д. Б. Кабалевский и многие другие). Рассмотрены вопросы теории перевода послереволюционного периода: стремление приблизиться к подлинному тексту, воспроизведение сложных образов и шекспировских метафор, сохранение разностиливого язык, вплоть до «грубости» афоризмов Шекспира (А. Радлова, М. Лозинский, М. Кузмин), отказ от дословности и стремление воспроизвести текст Шекспира живым современным языком (Б. Пастернак, С. Маршак, В. Левик, Ю. Корнеев, М. Донской, Т. Гнедич, П. Мелкова). Автор приходит к выводу, что вслед за Золотым веком Серебряный век привнес в русскую поэзию усиленный интересен к наследию британского поэта и драматурга в России конца XIX - начала ХХ вв.</p>
Патриотизм как модель воспитания и поведения
Authors: Макаревич Эдуард Федорович 
Published: May 2023

<p>В статье рассматривается понятие патриотизма как социально-нравственного явления на основе анализа моделей патриотического воспитания и поведения А. С. Пушкина, С. С. Уварова, Л. Штрауса, А. П. Чехова. На примере поведения личности по модели Л. Штрауса и по модели А. П. Чехова показаны особенности проявления патриотизма как определенного типа личности. При этом отмечена мировоззренческая база чеховской модели, включающая западноевропейскую философию и русскую философию. Патриотизм современной российской молодежи измеряется практикой ее поведения, которая рассмотрена на основе типов личности, свойственных молодежи 20-х гг. XXI в. и исследованных М. К. Горшковым, Ф. Э. Шереги и Ю. А. Зубок. Доказывается, что воспитание патриотизма неразрывно связано с процессом социализации личности, приобщения ее к определенному образу жизни, культуре предыдущих поколений, в которой значительную роль играет история и русская классическая литература, вовлеченности личности в действия государственного и общественного значения. Особо рассматривается метод воспитания патриотизма у выпускников высшей школы, связанный со стандартами обучения. </p>
The diagnostic value of the field assessment stroke triage as an emergency destination tool in identifying the obstruction of large cerebral vessels: a systematic review and meta-analysis
Authors: Nasiri-Valikboni Amirhossein , Baser Yazdan , Ramawad Hamzah Adel , Miri Reza , Yousefifard Mahmoud 
Published: May 2023

Objective: In this study, we investigate the diagnostic value of the field assessment stroke triage for emergency destination (FAST-ED) tool in the diagnosis of large vessels occlusion (LVO) in a systematic review and meta-analysis.
Methods: We conducted a search in Medline (PubMed), Embase, Scopus, and Web of Science databases until the 21st of September 2022, as well as a manual search in Google and Google scholar to find related articles. Studies of diagnostic value in adult population were included. Screening, data collection and quality control of articles were done by two independent researchers. The data were entered and analyzed in STATA 17.0 statistical program.
Results: The data from 30 articles were entered. The best cut-off points for FAST-ED were 3 or 4. The sensitivity and specificity of FAST-ED at cut-off points 3 were 0.77 (95% CI:0.73,0.80) and 0.76 (95% CI:0.72,0.80), respectively. These values ​​for cut-off point 4 were 0.72 (95% CI:0.65,0.78) and 0.79 (95% CI:0.75,0.82), respectively. Meta-regression showed that the sensitivity and specificity of FAST-ED performed by a neurologist was more accurate compared to emergency physician (P for sensitivity=0.01; P for specificity<0.001) and emergency medical technicians (P for sensitivity=0.03; P for specificity<0.001). Finally, it was found that the sensitivity of FAST-ED performed by the emergency physician and the emergency medical technician has no statistically significant difference (P=0.76). However, the specificity of FAST-ED reported by the emergency physician is significantly higher (P<0.001). The false negative rate of this tool at cut-off points 3 and 4 is 22.5% and 28.8%, respectively.
Conclusion: Although FAST-ED has an acceptable sensitivity in identifying LVO, its false negative rate varies between 22.5% and 28.8%. A percentage this high is unacceptable for a screening tool to aid in the diagnosis of strokes considering it has a high rate or morbidity and mortality. Therefore, it is recommended to use another diagnostic tool for the stroke screening.
The facial measurements in health workers at Dr. Sardjito General Hospital, Yogyakarta
Authors: Aliya Nadiya Husna , Rahmawati Neni Trilusiana , Hastuti Janatin , Febriana Sri Awalia 
Published: May 2023

The appropriate mask is based on facial anthropometric measurements that may be affected by sex, race, age, and body mass index (BMI). This study aimed to determine the difference and relationship between the bizygomatic width (BW) and nasion-menton height (NMH) with sex and BMI in health workers. This descriptive-analytical study used a cross-sectional method. The subjects were 39 health workers (nurses and doctors) at Dr. Sardjito General Hospital, Yogyakarta consisting of 15 male subjects and 24 female subjects, aged between 25-55 years old. Anthropometric measurements were performed on the subjects, including body weight, height, NW, and NMH. The data were analyzed using the Shapiro-Wilk test, independent t-test, and Pearson’s test. There was a significant difference in the BW between male and female subjects (p<0.05), with the males’ BW (13.1 ± 0.76 cm) being larger than that of the female subjects (12.35 ± 0.62 cm). There were no differences in the BMI and nasion-menton height between the male and female subjects (p>0.05). The Pearson’s test results showed no significant relationship between the BW with BMI in both the male subjects (r=0.351; p=0.199) and the female subjects (r=0.349; p=0.094), and between the nasion-menton height with BMI in both the male subjects (r=0.101; p=0.721) and the female subjects (r=0.390, p=0.060). In conclusion, the males’ BW was larger than the female health workers. It is necessary to consider facial anthropometric measurements in face mask manufacturing to provide comfort and good protection.
The NaCl–CaCO3–MgCO3 System at 3 GPa: Implications for Mantle Solidi
Authors: Shatskiy A.F. , Podborodnikov I.V. , Arefiev A.V. , Litasov K.D. 
Published: May 2023

Abstract—Alkaline chlorides are important constituents of carbonatitic inclusions in magmatic minerals from kimberlites and lamproites, mantle xenoliths from kimberlites, and diamonds from kimberlites and placers around the world. This indicates the participation of alkali chlorides, along with carbonates, in the processes of melting of mantle rocks, which makes it important to study chloride–carbonate systems at mantle pressures. In this work, we studied the phase relations in the NaCl–CaCO3–MgCO3 system at 3 GPa in the range of 800–1300 °С using a multianvil press. It has been found that the NaCl–CaCO3 and NaCl–MgCO3 binaries have the eutectic type of T–X diagram. The halite–calcite eutectic is situated at 1050 °C and Na2# = 36, while the halite–magnesite eutectic is located at 1190 °C and Na2# = 77, where Na2# = 2NaCl/(2NaCl + CaCO3 + MgCO3) · 100 mol.%. In the NaCl–CaCO3–MgCO3 ternary, subsolidus assemblages are represented by halite and calcium–magnesium carbonates. Just below solidus, two assemblages are stable: halite + magnesite + dolomite and halite + dolomite–calcite solid solution. The minimum on the liquidus/solidus surface corresponds to the halite–Ca0.84Mg0.16CO3 dolomite eutectic, located at about 1000 °С with Na2#/Ca# = 34/84, where Ca# = Ca/(Ca + Mg) · 100 mol.%. At Ca# ≤ 73, the melting is controlled by the halite + dolomite = magnesite + liquid ternary peritectic, located at 1050 °C with Na2#/Ca# = 31/73. According to the data obtained, it can be assumed that at 3 GPa the solidi of NaCl-bearing carbonated peridotite and eclogite are controlled by the peritectic reaction halite + dolomite = magnesite + liquid, located at about 1050 °C. The melting is accompanied by the formation of a chloride–carbonate melt containing (wt.%): NaCl (35), CaCO3 (56), and MgCO3 (9).