bluuebunny/crossref_metadata_2025_split huggingface dataset:
Circ_0070203 Promotes Epithelial-mesenchymal Transition in Ovarian
Serous Cystadenocarcinoma through miR-370-3p/TGFβR2 Axis
Authors: Tang Qiong , Wen Huiting , Hu Haoyue , Chen Xiaoli , Xu Shuxiu , Fan Li , Liu Longyang , Li Jing 
Published: March 2023

Introduction:
Circular RNAs (circRNAs) are important biological molecules associated
with the pathogenesis of multiple cancers.

Objective:
This work aimed to investigate the function and molecular mechanism of circ_0070203
in high-grade serous ovarian cystadenocarcinoma (HGSOC).

Methods:
circRNA microarray was conducted to detect the circ_0070203 expression in HGSOC
tissues. Bioinformatics analysis was used to find the binding sites between circ_0070203, miR-
370-3p and TGFβR2. Real-time quantitative reverse transcription PCR (RT-qPCR) was executed
to detect the expressions of circ_0070203, miR-370-3p and TGFβR2 in HGSOC tissues and
SKOV3 cells. Dual-luciferase reporter gene assay was used to validate the relationships between
miR-370-3p and circ_0070203 or TGFβR2. Besides, transwell assays were conducted to assess the
migrative, invasive abilities of ovarian cancer (OC) cells. Western blotting was adopted to detect
the expression of epithelial-mesenchymal transition (EMT)-related proteins. The related patents
were also studied during the research.

Results:
Circ_0070203 and TGFβR2 were upregulated, while miR-370-3p was downregulated in
FIGO stage Ⅲ-Ⅳ HGSOC tissues and SKOV-3 cell lines. circ_0070203 overexpression changed
the expression of other EMT-related proteins and enhanced the migrative, invasive abilities of OC
cells, while silencing circ_0070203 worked oppositely. Mechanistically, circ_0070203 could upregulate
TGFβR2 expression in OC cells via sponging miR-370-3p.

Conclusion:
Circ_0070203 could promote the epithelial-mesenchymal transition, invasion, and
metastasis of HGSOC via regulating the miR-370-3p/TGFβR2 axis. Our findings provided a potential
biomarker for HGSOC therapy.
Blood-brain Barrier and Neurovascular Unit Dysfunction in Parkinson's Disease: From Clinical Insights to Pathogenic Mechanisms and Novel
Therapeutic Approaches
Authors: Khor Sarah Lei Qi , Ng Khuen Yen , Koh Rhun Yian , Chye Soi Moi 
Published: March 2023

Abstract:
The blood-brain barrier (BBB) plays a crucial role in the central nervous system by tightly
regulating the influx and efflux of biological substances between the brain parenchyma and peripheral
circulation. Its restrictive nature acts as an obstacle to protect the brain from potentially noxious substances
such as blood-borne toxins, immune cells, and pathogens. Thus, the maintenance of its structural
and functional integrity is vital in the preservation of neuronal function and cellular homeostasis
in the brain microenvironment. However, the barrier’s foundation can become compromised during
neurological or pathological conditions, which can result in dysregulated ionic homeostasis, impaired
transport of nutrients, and accumulation of neurotoxins that eventually lead to irreversible neuronal
loss. Initially, the BBB is thought to remain intact during neurodegenerative diseases, but accumulating
evidence as of late has suggested the possible association of BBB dysfunction with Parkinson’s
disease (PD) pathology. The neurodegeneration occurring in PD is believed to stem from a myriad of
pathogenic mechanisms, including tight junction alterations, abnormal angiogenesis, and dysfunctional
BBB transporter mechanism, which ultimately causes altered BBB permeability. In this review, the
major elements of the neurovascular unit (NVU) comprising the BBB are discussed, along with their
role in the maintenance of barrier integrity and PD pathogenesis. We also elaborated on how the neuroendocrine
system can influence the regulation of BBB function and PD pathogenesis. Several novel
therapeutic approaches targeting the NVU components are explored to provide a fresh outlook on
treatment options for PD.
How do “Young-old” Adults Project their Self? A Study of Self-defining
Future Projections in Normal Ageing
Authors: Fritsch Alain , Voltzenlogel Virginie , Cuervo-Lombard Christine 
Published: March 2023

Background:
Self-defining future projections (SDFP) are mental representations of
plausible and highly significant future events that provide core information of one’s understanding
of self.

Objective:
We explored SDFPs in a large sample of older adults and aimed to target the interrelations
between the main dimensions of SDFPs. Moreover, correlations between these dimensions
and clinical and cognitive variables were examined.

Methods:
We recruited 87 young-old adults (60-75 years) with normal cognitive functioning who
were asked to generate three SDFPs.

Results:
We found integrative meaning as a salient dimension and older individuals preferentially
generated projections containing leisure or relationship events. Anxiety and self-esteem were correlated
with integrative meaning and high executive functioning was found to be protective towards
the simulation of future events containing dependence and death or end-of-life events.

Conclusion:
This study will contribute to the understanding of personal goals and identity in normal
ageing.
ANALISIS SEKTOR UNGGULAN KOTA LUBUKLINGGAU SEBAGAI KAWASAN STRATEGIS PROVINSI
Authors: Rahmaliza  , Prananing Tyas Wido 
Published: March 2023

Penetapan sektor unggulan pada Kota Lubuklinggau dilakukan untuk mengetahui sektor-sektor yang mendukung penetapan kawasan perkotaan Lubuklinggau sebagai kawasan strategis provinsi dari sudut kepentingan ekonomi. Metode penelitian ini bersifat deskriptif analitik dengan cara analisis sektor basis dengan metode Location Quotient (LQ) dan penentuan sektor unggulan dengan analisis Shift Share. Hasil analisis menunjukkan bahwa dari 17 sektor PDRB terdapat 11 sektor basis di Kota Lubuklinggau yang didominasi oleh sektor jasa, namun berdasarkan analisis Shift Share ada tujuh sektor yang merupakan sektor unggulan yaitu jasa lainnya, jasa kesehatan, real estat, penyediaan akomodasi dan makan minum, jasa perusahaan, perdagangan besar dan eceran serta transportasi dan pergudangan; tiga sektor potensial yaitu sektor pengadaan air; pengelolaan sampah, limbah dan daur ulang, kontruksi dan jasa pendidikan; empat sektor berkembang yaitu sektor pertambangan dan penggalian, industri dan pengadaan listrik dan gas, serta dua sektor tertinggal yaitu sektor pertanian, kehutanan, perikanan dan administrasi pemerintahan, pertanahan dan jaminan sosial. Sejalan dengan penetapan sebagai kawasan strategis provinsi hasil analisis dapat menjadi rekomendasi fokus pembangunan agar tepat sasaran dan meningkatkan daya saing ekonomi daerah. Dalam rangka optimalisasi tersebut penyerapan tenaga kerja dan penambahan jumlah penduduk juga perlu diperhatikan sebagai dasar dalam optimalisasi kinerja sektor ekonomi pada masa mendatang sehingga meningkatkan pertumbuhan ekonomi.
Kata kunci : Location quotient, shift share, Kota Lubuklinggau, kawasan strategis provinsi
The Evaluation of the Combination of Additives and Fungal Dyes to Produce Color for Textile Painting
Authors: Nugroho Agung Adi , Suciatmih Suciatmih 
Published: March 2023

Fungal dyes are an eco-friendly alternative to synthetic dye. This study aims to evaluate additives to dye, using mixed fungi, to paint the picture on cloth. In the present study, the cloth was painted with mixed Aspergillus and Paecilomyces dye. The mixed fungi were grown on a mineral salt glucose medium. Five tests were conducted to evaluate additives to dye from mixed fungi that could be used to paint pictures on cloths to evaluate the effect of additives, a combination of additives producing tidy colors and other additives, the dye pH, mordant, and a variety of different mordants and the dye pH on color tidiness and hue. The additives used were alkali, acid, salts, glycerine, and urea. The Royal Horticultural Society (RHS) color chart was used to measure the color of filtrate and range developed on the painted color on the cloth. The results showed that the mixture of vinegar or lemon as additives and the dye pH of 3 produced tidy colors. The mordant application had a more significant effect on the color that appears than pH treatment. Colors formed on images can add variations to textile painting.
The Association of Background Medications on Initial eGFR Change and Kidney Outcomes in Diabetic Patients Receiving SGLT2 Inhibitor
Authors: Chan Yi-Hsin , Chao Tze-Fan , Chen Shao-Wei , Kao Yi-Wei , Huang Chien-Ying , Chu Pao-Hsien 
Published: March 2023

Background
To determine whether background medications modify the effects of sodium-glucose cotransporter-2 inhibitor (SGLT2i) on the eGFR and kidney outcomes among patients with type 2 diabetes.

Methods
We used medical data from a multicenter health care facility in Taiwan and included 10,071 patients who received SGLT2i treatment from June 1, 2016, to December 31, 2018. Direct comparisons for use versus no use of specific background drugs were conducted after adjusting for baseline characteristics through propensity score matching. Patients were followed up until the occurrence of composite kidney outcomes (two-fold increase in the serum creatinine level or the development of end-stage kidney disease), mortality, or the end of the study period.

Results
Patients exhibited an initial mean (SEM) decline of −2.72 (0.10) ml/min per 1.73 m2 in eGFR dip from baseline to a mean treatment duration of 8.1±3.1 weeks after SGLT2i initiation. The eGFR trajectory stabilized 24 weeks after SGLT2i treatment with a mean (SEM) slope of −1.36 (0.25) ml/min per 1.73 m2 per year. Compared with no drug use, the use of background renin-angiotensin inhibitor (n=2073), thiazide diuretics (n=1764), loop diuretics (n=708), fenofibrate (n=1043), xanthine oxidase inhibitor (n=264), and insulin (n=1656) was associated with a larger initial decrease in eGFR, while background metformin treatment (n=827) was associated with a smaller initial decrease in eGFR after SGLT2i treatment. The only drugs associated with the long-term composite kidney outcome during SGLT2i treatment were renin-angiotensin inhibitor (hazard ratio [HR], 0.61; 95% confidence interval [CI], 0.40 to 0.95) and loop diuretics (HR, 1.88; 95% CI, 1.19 to 2.96).

Conclusions
Several background medications were associated with the initial eGFR dip after SGLT2i initiation. Most drugs were not associated with long-term composite kidney outcomes among patients treated with SGLT2i, except for renin-angiotensin system inhibitor associated with favorable outcomes and loop diuretics associated with worse composite kidney outcomes.
Kidney Adverse Events Associated with Immune Checkpoint Inhibitor Therapy
Authors: Trisal Shehjar R. , Low Gary , Pathan Faraz , Gangadharan Komala Muralikrishna 
Published: March 2023

Background
The blockade of immune regulatory sites, cytotoxic T-lymphocyte antigen 4, programmed cell death 1 (PD-1), and programmed cell death ligand 1 (PD-L1) with immune checkpoint inhibitors has revolutionized survival outcomes in patients with cancer. However, immune checkpoint inhibitors are associated with a range of immune-related adverse events. The aim of this network meta-analysis was to evaluate severe adverse kidney events in patients with oncological or hematological malignancy receiving monotherapy, dual therapy, or combined therapy treatment with immune checkpoint inhibitors when compared with either placebo or standard chemotherapy.

Methods
Phase 3 randomized control trials reporting severe grade (3–5) adverse kidney events were identified across five electronic databases from inception to May 2022. This was supplemented with hand searching of medical journals and the National Clinical Trials registry. A Bayesian network meta-analysis was performed for AKI, hypertension, CKD, and the composite of all acute kidney adverse events. The results are reported as per the PRISMA guidelines.

Results
Ninety-five randomized control trials reported severe grade adverse kidney events. The risk of developing severe AKI is higher among patients who received PD-1 plus chemotherapy (odds ratio [OR], 1.8; 95% credible interval [CrI], 1.4 to 2.5) and PD-L1 plus chemotherapy (OR, 1.8; 95% CrI, 1.2 to 2.7) compared with standard chemotherapy and placebo (94 studies, 63,357 participants). The risk of developing the composite of all severe acute kidney adverse events is higher among patients who received PD-1 plus chemotherapy (OR, 1.6; 95% CrI, 1.1 to 2.3) and PD-L1 plus chemotherapy (OR, 1.7; 95% CrI, 1.1 to 2.8) when compared with standard chemotherapy and placebo (95 studies, 63,973 participants).

Conclusions
The combined regimen of PD-1 plus chemotherapy and PD-L1 plus chemotherapy was associated with higher incidence of severe AKI and the composite of all severe acute kidney adverse events.

Podcast
This article contains a podcast at https://dts.podtrac.com/redirect.mp3/www.asn-online.org/media/podcast/CJASN/2023_07_10_CJN0000000000000160.mp3
Quais os meios de prova no crime insider trading nos Estados Unidos da América?
Authors: Gomes Ives Nahama , Dionísio de Andrade Mariana 
Published: March 2023

Este estudo objetiva responder: quais os meios de prova usados em casos criminais de insider trading nos Estados Unidos da América (EUA)?; Há a possibilidade desses meios de prova serem aplicados nas ações penais brasileiras sobre o tema?. Estabelece-se o conceito do uso de informações privilegiadas em sua faceta criminal pela exposição das controvérsias na temática e de como esta é tratada na literatura nacional e internacional, por constituir um estudo comparado. Depois, aborda-se a Metodologia de Análise de Decisões como forma de investigação empírica, para que se discuta a atividade probatória nos crimes de insider trading. Discute-se como os EUA enfrentam o assunto, especialmente, quanto ao papel das provas, para trazer elementos para o aplicador da lei brasileira. A abordagem é qualitativa e quantitativa, com revisão de literatura e Metodologias de Análise de Conteúdo e Análise de Decisões. A unidade de análise são casos criminais estadunidenses, em 2019. Concluem-se como meios de prova usados nestes: quebra de sigilo telefônico; confissão; testemunhos; prova emprestada; comunicação com sindicatos; análise estatística; artigos de jornais e conclusões do Comitê de Auditoria da própria empresa. São provas, plenamente, possíveis de levantamento e construção pelo Judiciário criminal brasileiro, então, apresentam-se propostas de melhoria.
The role of female farmers in improving family welfare in South Bali Sadhar Village Banjit District Way Kanan Regency, Lampung
Authors: Rangga Kordiyana K , Syarif Yuniar Aviati , Ibnu Muhammad , Widiastri Ni Luh Kadek 
Published: March 2023

This study aims at contructingthe role of female farmers in improving family welfare. The research was carried out in March 2022-April 2022 in South Bali Sadhar Village, Banjit District, Way Kanan Regency. Lampung. Indonesia. The informants in this study were female farmers and male farmers who worked in the lowland rice sector with a total of 12 people, consisted of 6 women and 6 men. The approach used in this study is a qualitative approach with case studies method. Data analysis used in this study is reduce data, data colection, data presentation and conclusions drawing. The results of this study indicate that the role of female farmers in the village of South Bali Sadharin improving family welfare is divided into three parts are reproductive role, productive role and social role. The reproductive role as housewives, the productive role as lowland rice farmers and as farm laborers. These activities include preparation of production facilities, seeding, planting, maintenance, harvesting and post-harvest. The social role is as a member of the community in both general and religious activities. The involvement of women in these three types of roles can help improve family welfare, for example women helping their husbands earn a living as lowland rice farmers so that family needs can be gradually met
Phenotypes Associated with Zones Defined by Area Under the Curve Glucose and C-peptide in a Population with Islet Autoantibodies
Authors: Sosenko Jay M. , Cuthbertson David , Sims Emily K. , Ismail Heba M. , Nathan Brandon M. , Jacobsen Laura M. , Atkinson Mark A. , Evans-Molina Carmella , Herold Kevan C. , Skyler Jay S. , Redondo Maria J. , Group theTrialNet Study 
Published: March 2023

<p> </p>
<p><strong>Objective</strong></p>
<p>Metabolic zones were developed to characterize heterogeneity of individuals with islet autoantibodies.</p>
<p><strong>Research Design and Methods</strong></p>
<p>Baseline 2-hour oral glucose tolerance test (OGTT) data from 6,620 TrialNet Pathway to Prevention Study (TNPTP) autoantibody-positive participants (relatives of individuals with type 1 diabetes) were used to form 25 zones from 5 AUC glucose (AUCGLU) rows and 5 AUC C-peptide (AUCPEP) columns. Zone phenotypes were developed from demographic, metabolic, autoantibody, HLA, and risk data.</p>
<p><strong>Results</strong></p>
<p>As AUCGLU increased, changes of glucose and C-peptide response curves (GCRCs; from mean glucose and mean C-peptide values at 30,60,90,120 minutes) were similar within the 5 AUCPEP columns. Among the zones, 5-year risk for type 1 diabetes was highly correlated with IA-2A prevalence (r=0.96, p<0.001). Disease risk decreased markedly in the highest AUCGLU row as AUCPEP increased (0.88 to 0.41; p<0.001 from lowest AUCPEP to highest AUCPEP column). AUCGLU correlated appreciably less with Index60 (indicator of insulin secretion) in the highest AUCPEP column (r=0.33) than in other columns (r≥0.78). AUCGLU was positively related to “fasting glucose x fasting insulin” and to “fasting glucose x fasting C-peptide” (indicators of insulin resistance) before and after adjustments for Index60 (p<0.001). </p>
<p><strong>Conclusions</strong> </p>
<p>Phenotypes of 25 zones formed from AUCGLU and AUCPEP were used to gain insights into type 1 diabetes heterogeneity. Zones were utilized to examine GCRC changes with increasing AUCGLU, associations between risk and autoantibody prevalence, the dependence of glucose as a predictor of risk according to C-peptide, and glucose heterogeneity from contributions of insulin secretion and insulin resistance.</p>
Pengendalian Mutu Alat Skir Katup Otomatis Menggunakan Peta Kendali dengan Metode Bootstrap
Authors: Oksarianti Yuvani , Fitria Dina 
Published: March 2023

Compression leaks occur in valves caused by soot resulting from the combustion process of the combustion engine. To overcome valve leaks, it’s necessary to clean using an innovative tool called valve grinding automatic system. The purpose of this study was to determine the quality of this tool based on the control chart using the bootstrap method. Based on the research results, the control charts dan R show that the cleaning process is in a controlled and stable state (in statistical control). The quality of the valve cleaning process using this tool is able of producing cleaning according to standard cleaning specifications.
Meningkatkan Kemampuan Berpikir Kreatif Peserta Didik Melalui Teknik Divergent Thinking dan Mind Mapping Dalam Pembelajaran PPKn
Authors: Khoerudin Cep Miftah , Alawiyah Titi , Sukarliana Lili 
Published: March 2023

AbstractThinking skills are necessary to face complex and dynamic challenges in daily life. This study aims to identify the improvement of creative thinking skills through divergent thinking and mind-mapping techniques. The research method used is quasi-experimental with a pre-test and post-test control group design. The research sample consisted of 60 eighth-grade students in Bandung. The results of the study show that there is a significant difference in creative thinking skills between the experimental group, who were given divergent thinking and mind mapping techniques, and the control group, who were only given conventional learning. The t-test results show that the average score of the experimental group significantly increased from the pre-test, with an average of 80.01. In addition, the effect size test results show an influence of 0.912. This suggests that divergent thinking and mind-mapping techniques can be effective strategies to improve the creative thinking skills of students, and educators should consider using these techniques in the learning process to enhance students' creative thinking abilities.------------AbstrakKemampuan berpikir diperlukan menghadapi tantangan yang kompleks dan dinamis dalam kehidupan sehari-hari. Penelitian ini bertujuan untuk mengidentifikasi peningkatan kemampuan berpikir kreatif melalui teknik divergent thinking dan mind mapping. Metode penelitian yang digunakan adalah quasi-experimental dengan desain pre-test dan post-test control group. Sampel penelitian terdiri dari 60 orang peserta didik kelas VIII SMP di Kota Bandung. Hasil penelitian mengungkap bahwa terdapat perbedaan signifikan antara kualitas keterampilan berpikir kreatif pada kelompok eksperimen yang diberikan teknik divergent thinking dan mind mapping dengan kelompok kontrol yang hanya diberikan pembelajaran konvensional. Hasil uji t-test menunjukkan bahwa nilai rata-rata pada kelompok eksperimen meningkat secara signifikan dari pre-test dengan rata rata 80,01. Selain itu, hasil uji menggunakan effect size terdapat pengaruh sebesar 0,912. Hal tersebut menunjukkan bahwa teknik divergent thinking dan mind mapping dapat menjadi strategi yang efektif untuk meningkatkan kemampuan berpikir kreatif pada peserta didik yang berimplikasi adalah bahwa pendidik harus mempertimbangkan penggunaan teknik-teknik tersebut pada proses pembelajaran untuk meningkatkan keterampilan berpikir kreatif peserta didik.
Mercury accumulation in bivalve molluscs in hydroecosystem of Red River estuary (Vietnam)
Authors: Nguyen Thi Thui Nhung , Volkova Irina Vladimirovna 
Published: March 2023

The article presents analysis of mercury content in different tissues such as gills, mantle, hepatopancreas and body (leg) in 4 species of bivalve molluscs in the estuary of the Red River in Vietnam. The studies were carried out in 2016–2021 during the main hydrological seasons (during the summer flood and winter low water) at 37 stations in the delta and estuarine coast of the Red River. There are shown the dependences of mercury content in mollusc tissues on the age parameters (length and mass of tissues) and on the content of pollutant in dissolved, suspended forms of near-bottom water layers and in bottom sediments. The mercury content in the tissues of molluscs varies whithin 0,023 ± 0,001 to 0,459 ± 0,007 mg/kg wet weight. The highest content of mercury was found in the hepatopancreas
of Austriella corrugata, and the lowest - in the leg of Lutraria rhynchaena. Significant close positive correlations were registered between the mercury concentrations in the mollusc tissues and the mercury content in the near-bottom water layer and in bottom sediments (r from 0.68 to 0.92, p < 0.05). All studied species of molluscs are classified as macroconcentrators of mercury in water; Austriella corrugata can actively accumulate mercury not only from the water, but also from the bottom sediments. Bivalve molluscs can be used as an object of biomonitoring when studying the distribution of mercury in the estuary of the Red River.