bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sensitivity Analysis of Operation Parameters of the Salt Cavern under Long-term Gas Injection-Production
Authors: ZHANG Huabin , WANG Peng , Wanyan Qiqi , Li Kang , Gao Kai , Yue Xianru 
Published: March 2023

Abstract
Injection-production operation parameters, the minimum injection gas pressure (IGP: operation pressure), IGP interval, minimum IGP residence time, and injection-production cycle of the underground salt rock gas storage under long-term operation, affect not only the capacity and working ability of a salt cavern but also be crucial to the safety and stability of the surrounding rock. A 3D geo-mechanical model of the salt cavern is established to study the stability of the storage in the operation period. The deformation, expansion safety factor, volume shrinkage, and plastic zone are comprehensively considered for predicting the feasibility and stability of the salt cavern. The stability of the surrounding rock of the cavern with different injection-production parameters and the impact of each parameter on the stability of the cavern during operating are systematically investigated. The results indicate that the displacement, the expansion coefficient of the surrounding rock, and the volume shrinkage rate of the salt cavern reduces significantly with the increment of IGP interval and minimum IGP, while they increases with raising the minimum IGP residence time and injection-production cycle. With the continuous operation of the cavity, the displacement and the volume shrinkage rate enhances significantly year by year with the augment of operation parameters, moreover, their value show a fluctuating upward trend with the alternation of the gas injection and the production. The volume of the plastic zone is enlarged with the increment of the IGP interval, minimum IGP, and injection-production cycle, while it reduces with the extension of the minimum IGP residence time. The variation becomes remarkably with the augment of parameters. The sensitivity coefficients of each injection-production operation parameter are ranked, from large to small, as follows: IGP interval, minimum IGP, minimum IGP residence time, injection-production cycle. The results can offer beneficial reference for effectively optimize the injection-production parameters, so as to provide technical guidance for ensuring the stability of the storage and meeting requirements for the storage capacity.
Using patient-specific contrast enhancement optimizer simulation software during the transcatheter aortic valve implantation-computed tomography angiography in patients with aortic stenosis
Authors: Masuda Takanori , Nakaura Takeshi , Higaki Toru , Funama Yoshinori , matsumoto Yoriaki , Sato Tomoyasu , Okimoto Tomokazu , Gotanda Rumi , Arao Keiko , Imaizumi Hiromasa , Arao Shinichi , Ono Atsushi , Hiratsuka Junichi , Awai Kazuo 
Published: March 2023

Abstract
Purpose: This study assessed whether patient-specific contrast enhancement optimizer simulation software (p-COP) can reduce the contrast material (CM) dose compared with the conventional body weight (BW)-tailored scan protocol during transcatheter aortic valve implantation-computed tomography angiography (TAVI-CTA) in patients with aortic stenosis.
Methods: We used the CM injection protocol selected by the p-COP in group A (n = 30). The p-COP uses an algorithm that includes data on an individual patient’s cardiac output. Group B (n = 30) was assigned the conventional BW-tailored CM injection protocol. We compared CM dose, amount of CM, injection rates, and computed tomography (CT) value in the abdominal aorta between the two groups and classified them as acceptable (>280 Hounsfield units (HU)) or unacceptable (<279 HU) based on the optimal CT value for TAVI-CTA.
Results: Group A received 56.2 ml CM and 2.6 ml/sec of injection, and group B received 76.9 ml CM and 3.4 ml/sec of injection (p < 0.01). The CT value for the abdominal aorta at the celiac level was 287.0 HU in group A and 301.7HU in group B (p = 0.46). The rate of CT value for acceptable (280 HU or more) and unacceptable (less than 280 HU) were 22 and 8 patients in group A, and 24 and 6 patients in group B, respectively (p = 0.76).
Conclusion: The p-COP reduced the CM dosage, and the injection rate was approximately 30% in patients with aortic stenosis compared with the BW-tailored scan protocol during TAVI-CTA.
A survey on χ-module Connes Amenability of Semigroup Algebras
Authors: Tamimi Ebrahim , Ghaffari Ali 
Published: March 2023

Abstract
We shall study the χ-module Connes amenability of a semigroup algebra l 1(S), where χ is a bounded module homomorphism from l 1(S) to l 1(S) that is w∗-continuous and S is an inverse weakly cancellative semigroup with subsemigroup E of idempotents. We are mainly concerned with the study of χ-module normal, virtual diagonals. We characterize the χ- module Connes amenability of a semigroup algebra l1(S). Also, we show that if l1(S) as a Banach module over l1(E) has an id-module normal, virtual diagonal then it is id-module Connes amenable. It is obtained other characterizations for χ- module Connes amenability of l1(S).
Molecular Evolution and Protein Structure Variation of Dkk Family
Authors: Wen Binhong , Gong Husile , Yin Jun , Wu Jianghong , Guo WenRui 
Published: March 2023

Abstract
Dkks have inhibitory effects on Wnt signaling pathway, which is involved in the development of skin and its appendages and the regulation of hair growth. The nucleotide sequences were compared and analyzed to further investigate the relationship between the structure and function of the Dkk gene family and vertebrate epidermal hair. The analysis of the molecular evolution of the Dkk family revealed that the evolution rate of the gene changed significantly after species differentiation, with the Aves and Reptilia branches showing accelerated evolution. Additionally, positive selection was observed at specific sites. The tertiary structure of the protein was also predicted. The analysis of the functional divergence of the Dkk family revealed that the functional divergence coefficient of each gene was greater than 0, with most of the functional divergence sites located in the Cys-2 domain and a few in the Cys-1 domain. This suggests that the amino acid and functional divergence sites may play a role in regulating the binding of Dkk family to LRP5/6, and thus affect the inhibition of Wnt signaling, leading to different functions of Dkk1, Dkk2, and Dkk4 in the development of skin hair follicles. In addition, the Dkk families of Aves and Reptilia may have undergone adaptive evolution and functional divergence.
Risk factor analysis of tibial tunnel position for early failure of anterior cruciate ligament reconstruction
Authors: Niu Haiyun 
Published: March 2023

Abstract
BACKGROUND: To study the effect of the positional relationship between the position of the opening within the tibial tunnel and the extension of the parietal line of the intercondylar fossa on early graft rupture after ACLR.
METHODS: Patients were divided into three groups A, B, and C according to the positional relationship between the extension of the top line of the intercondylar fossa of the femur and the opening within the tibial tunnel, and risk factors related to the relationship between their age, sex, graft diameter, BMI, and graft survival of the affected knee and its position were analyzed and compared.
RESULTS: The age, BMI, and gender of the patients in the three groups were not statistically significant; the mean graft diameter of the patients in the three groups was statistically significant, and the mean graft diameter size was statistically different between group A and group C, and between group B and group C. The mean graft diameter in group C was larger than that in groups A and B; the graft survival rate of the patients in the three groups was statistically significant, and the graft survival rate in groups A and C was higher than that in group B.
Conclusion: The more posterior the position of the extension line of the top line of the intercondylar fossa intersecting the inner exit of the tibial tunnel, the more serious the impingement of the femoral intercondylar fossa with the graft, and the higher the early graft rupture rate after the reconstruction of the anterior cruciate ligament; It is not that the larger the graft diameter, the lower the graft rupture rate; the most effective measure to avoid early graft rupture is a reasonable tibial tunnel position to avoid the impingement on the graft.
Hierarchical deconvolution for extensive cell type resolution in the human brain using DNA methylation
Authors: Zhang Ze , Wiencke John K. , Kelsey Karl T. , Koestler Devin C. , Molinaro Annette M. , Pike Steven C , Karra Prasoona , Christensen Brock C. , Salas Lucas A. 
Published: March 2023

Abstract
The human brain comprises heterogeneous cell subtypes whose composition can be altered with physiological and pathological conditions. New approaches to discern the diversity and distribution of brain cells associated with neurological conditions would significantly advance the study of brain-related pathophysiology and neuroscience. We demonstrate that DNA-based cell-type deconvolution achieves an accurate resolution of seven major cell types. Unlike single-nuclei approaches, DNA methylation-based deconvolution does not require special sample handling or processing, is cost-effective, and easily scales to large study designs. Current methods for brain cell deconvolution are limited only to neuronal and non-neuronal cells. Using DNA methylation profiles of the top cell-type-specific differentially methylated CpGs, we employed a hierarchical modeling approach to deconvolve GABAergic neurons, glutamatergic neurons, astrocytes, microglial cells, oligodendrocytes, endothelial cells, and stromal cells. We demonstrate the utility of our method by applying it to data on normal tissues from various brain regions and in aging and diseased tissues, including Alzheimer's disease, autism, Huntington’s disease, epilepsy, and schizophrenia. We expect that the ability to determine the cellular composition in the brain using only DNA from bulk samples will accelerate understanding brain cell type composition and cell-type-specific epigenetic states in normal and diseased brain tissues.
HIV infection risk among women in South Africa: exploring the interplay between financial autonomy, sexual autonomy and intimate partner violence
Authors: Ogbodo Stephen Chukwuma 
Published: March 2023

Abstract

Aim: To assess the inter-relationships between women’s sexual autonomy (SA), financial autonomy (FA) and experience of intimate partner violence (IPV), and how these factors influence HIV infection risk.
Subject and Methods: This is a secondary analysis of the 2016 South-Africa Demographic and Health Survey. The study included all ever-partnered women aged 18-49 who were randomly selected for the domestic violence and HIV test modules. SA was measured from questions about women’s ability to refuse sex or request condom use. FA was measured from questions about women’s employment status, personal earnings, etc. IPV was measured from questions about women’s experience of emotional, physical and/or sexual violence. Bivariate analyses were used to assess the inter-relationships between SA, FA and IPV, and their individual relationships with HIV. Lastly, a multiple logistic regression model assessed their mutually adjusted associations with HIV infection risk.
Results: There was no apparent relationship between sexual and financial autonomy, but they were weakly inversely associated with IPV. In the bivariate analyses, all three variables were associated with HIV risk. However, in the mutually adjusted model, only SA and IPV remained associated with HIV risk. Low SA (AOR = 2.01, 95% CI: 1.30 to 3.10, p=0.006) and exposure to sexual violence (AOR = 2.91, 95% CI: 1.14 to 7.43, p = 0.03) were associated with higher odds of HIV seropositivity.
Conclusion: This study highlighted the important roles of SA and IPV on women’s HIV risk, as well as the need for further research to clarify the role of FA.
Abnormalities in modular connectivity of functional brain networks and cognitive changes in patients with anti -N-methyl-D-aspartate receptor encephalitis
Authors: Huang Dongying , Lv Caitiao , Chen Zexiang , Li Zhekun , Zheng Jinou 
Published: March 2023

Abstract
Objective: To explore potential mechanisms of cognitive changes in patients with anti-NMDAR encephalitis (ANMDARE) from intramodule and intermoduleeffects of brain functional networks.
Methods: Resting-state functional MRI and T1-weighted imaging data were collected from 30 ANMDARE patientsand 30 healthy controls (HCs). Abrain functional matrix was constructed, and sparsity was established by module similarity. For both groups, changes in functional connectivity within and between modules was calculated, changes in whole-brain and module gray matter volumes were explored, and whole-brain functional topology was analyzed. Finally, the association of brain functional and structural changes with cognitive function in ANMDARE was further analyzed.
Results: Compared to HCs, ANMDARE patients had enhanced connectivity within the modules that included the occipito-parietal-temporal and parahippocampal gyri. ANMDARE patients had significantly higher participation coefficients (PC) in the right inferior frontal gyrus than HCs and significantly lower PC in the left superior parietal lobule, left caudate nucleus, and right putamen. No statistically significant differences in gray matter volume and global topological properties were found between the two groups. No correlations were found between functional and structural brain indicators and the Cognitive Assessment Scale and the Emotional Deficit Scale.
Conclusions: Changes in cognitive function in patients with ANMDARE are manifested by enhanced intramodular functional connectivity and intermodularconnectivity changes in the brain, with abnormal intramodular and extramodularconnectivity that do not maintain normal cognitive function.
Variation of chemical compositions and fatty acids profiles of Chlorella sp. utilizing physical shocks
Authors: Noori Farzaneh , vahdat saeid 
Published: March 2023

Abstract
The biochemical compositions of microalgae are altered with the change in pH, temperature, photoperiod, salinity, and metal content in the culture media. This study aimed to evaluate the effect of different environmental shocks on the lipid, EPA, and DHA fatty acids levels in Chlorella sp. The algae were cultivated for 12 days using a Guillard medium for biomass production. At this stage, algae were reared under eight shock conditions for six days; T1 (control), T2 was subjected to salinity+pH+starvation, T3 to salinity, T4 to starvation, T5 to pH+starvation, T6 to salinity+pH, T7 to salinity+starvation and T8 to pH shocks. The samples were collected at the end of the dark or light period. The results revealed that the lipid content of Chlorella sp. was significantly affected by darkness in T6. The lipid content under salinity shock during the light period was significantly lower than T5 on day 18. The Arachidonic acid (ARA) and EPA in T4 and DHA in T6 during the dark period exhibited significant differences compared to other groups (p<0.05). Based on the results obtained highest lipid production and DHA synthesis in chlorella sp. were induced on day 18 during the dark period by T4 and T6, respectively.
Thrombotic microangiopathy after long lasting treatment by Gemcitabine: description, evolution and treatment of a rare case report
Authors: Bertin Lise , Gauthier Marion , Boullenger Fanny , Brocheriou Isabelle , Mary Florence , Dhôte Robin , Belenfant Xavier 
Published: March 2023

Abstract
Background : Thrombotic microangiopathy is an uncommon but severe complication that may occur in cancer patients under Gemcitabine chemotherapy. Gemcitabine induced thrombotic microangiopathy can clinically and biologically present as atypical hemolytic uremic syndrome, with activation of the complement pathway asking the question of the use of Eculizumab.
Case presentation : We describe here the case of a patient suffering from metastatic cholangiocarcinoma treated by Gemcitabine for 4 years leading to remission of the underlying neoplasia. Despite an impressive response to therapy, she developed thrombopenia, regenerative anemia and acute kidney injury leading to the suspicion then diagnosis based on renal biopsy of a very late Gemcitabine associated thrombotic microangiopathy. Spontaneous evolution after treatment interruption was favorable without dialysis requirement. However, in this case where Gemcitabine is the only chemotherapy remaining for a mortal underlying condition, we discussed re-initiation of Gemcitabine under Eculizumab treatment.
Conclusions : This atypical case of thrombotic microangiopathy illustrates the importance of recognizing, even belatedly, this rare but serious complication of chemotherapy. It asks the question of resumption of discontinued chemotherapy notably under Eculizumab cover, in this population with high risk of cancer progression.
A New ECG Denoising Approach based on convex fused-Lasso Denoising with Non-Convex Regularization and Wavelet/Total Variation
Authors: Rezgui Abdallah , Nasraoui Ibrahim , Talbi Mourad 
Published: March 2023

Abstract

In this paper, we propose a new Electrocardiogram (ECG) denoising approach based on Convex fused lasso Denoising with non-convex regularization and Wavelet/Total Variation (WATV). This approach consists at first step of applying the Discrete Wavelet Transform (DWT) to the noisy ECG signal for obtaining a noisy approximation coefficient, cAb1 and a noisy details coefficient, cDb1. The latter is denoised by soft thresholding and we obtain a denoised details coefficient, cDd1. The second step of this approach consists of applying the DWT to cAb1 in order to obtain a noisy approximation coefficient, cAb2 and a noisy details coefficient, cDb2. The latter is denoised by Convex fused lasso denoising with non-convex regularization and we obtain a denoised details coefficient, cDd2. The coefficient, cAb2, is denoised by WATV based denoising technique and we obtain a denoised coefficient, cAd2. The inverse of DWT is then applied to cDd2 and cAd2 in order to obtain a denoised approximation coefficient, cAd1. The inverse of DWT is again applied to cDd1 and cAd1 for obtaining finally a denoised ECG signal. The performance of this proposed approach is proved by the computation of SNR, the PSNR, the MSE, the Mean Absolute Error (MAE), and the Cross-Correlation (CC).
Sex differences in resting-state functional networks in awake rats
Authors: Li Qiong , Zhang Nanyin 
Published: March 2023

Abstract
Sex-related differences can be found in many brain disorders and psychophysiological traits, highlighting the importance to systematically understand the sex differences in brain function in humans and animal models. Despite emerging effort to address sex differences in behaviors and disease models in rodents, how brain-wide functional connectivity (FC) patterns differ between male and female rats remains largely unknown. Here we used resting-state functional magnetic resonance imaging (rsfMRI) to investigate regional and systems-level differences between female and male rats. Our data show that female rats display stronger hypothalamus connectivity, whereas male rats exhibit more prominent striatum-related connectivity. At the global scale, female rats demonstrate stronger segregation within the cortical and subcortical systems, while male rats display more prominent cortico-subcortical interactions, particularly between the cortex and striatum. Taken together, these data provide a comprehensive framework of sex differences in resting-state connectivity patterns in the awake rat brain, and offer a reference for studies aiming to reveal sex-related FC differences in different animal models of brain disorders.
Phylogenetic analysis of HA and NA genes of influenza A viruses in immunosuppressed inpatients in Beijing during the 2018-2020 influenza seasons
Authors: Liu Yafen , Wang Yue , Wang Yanxin , Mai Huan , Chen YuanYuan , Zhang Yifan , Ji Ying , Cong Xu , Gao Yan 
Published: March 2023

Abstract
Background
Influenza A viruses have undergone rapid evolution with virulent; however, complete and comprehensive data on gene evolution and amino acid variation of HA and NA in immunosuppressed patients was few. In this study, we analysed molecular epidemiology and evolution of influenza A viruses in immunosuppressed population, and immunocompetent population were used as controls.
Methods
A(H1N1)pdm09 and A(H3N2) were confirmed by reverse transcription-polymerase chain reaction (RT-PCR). HA and NA genes were sequenced using the Sanger method and phylogenetically analysed using ClustalW 2.10 and MEGA software version 11.0.
Results
During the 2018–2020 influenza seasons, 54 immunosuppressed and 46 immunocompetent inpatients were verified using RT–PCR. 27 immunosuppressed and 23 immunocompetent samples were randomly selected and sequenced using the Sanger method. A(H1N1)pdm09 were detected in 15 samples and the remaining 35 samples were A(H3N2) positive. By analyzing the HA and NA gene sequences of these virus strains, we found that all A(H1N1)pdm09 viruses shared high similarities to each other and the HA and NA genes of these viruses exclusively belonged to subclade 6B.1A.1. Some NA genes of A(H3N2) viruses were not in the same clade as those of A/Singapore/INFIMH-16-0019/2016 and A/Kansas/14/2017, which may have led to A(H3N2) being the dominant strain in the 2019–2020 influenza season. Both A(H1N1)pdm09 and A(H3N2) viruses showed similar evolutionary lineages patterns of HA and NA between immunosuppressed and immunocompetent patients. However, compared with the vaccine strains, the HA and NA nucleotide and amino acid sequences of influenza A viruses in immunosuppressed patients were less similar than those in immunocompetent patients. A total of 18 unreported substitutions were observed, 12 substitutions of which from immunosuppressed patients. Furthermore, the oseltamivir resistance substitution of NA-H275Y and R292K have been observed in immunosuppressed patients.
Conclusions
A(H1N1)pdm09 and A(H3N2) viruses showed similar evolutionary lineages patterns of HA and NA between immunosuppressed and immunocompetent patients. Compared with immunocompetent patients, immunosuppressed patients have more amino acid variations, which should be of note monitored, especially those with potential to affect the viral antigen.
Enzymatic synthesis of novel pyrrole esters and their thermal stability
Authors: Hu Jingyi , Zhou Meng , Zhang Yujie , Zhang Xi , Ji Xiaoming , Zhao Mingqin , Lai Miao 
Published: March 2023

Abstract
In the present work a simple enzymatic approach (Novozym 435) for transesterification to synthesize pyrrole esters was reported. To generate the best reaction conditions, which resulted in the optimum yield of 92%, the effects of lipase type, solvent, lipase load, molecular sieves, substrate molar ratio of esters to alcohol, reaction temperature, reaction duration, and speed of agitation were evaluated. The range of alcohols was assessed under optimal circumstances. The spectrum observations conclusively demonstrated that the compounds could be generated with high yield under the circumstances utilized for synthesis. The odor characteristics of the pyrrolyl esters obtained were examined by gas chromatography-mass spectrometry-olfactometry (GC-MS-O). Among them, compounds of benzhydryl 1H-pyrrole-2-carboxylate (3h), butyl 1H-pyrrole-2-carboxylate (3i) and pentyl 1H-pyrrole-2-carboxylate (3j) present sweet and acid aroma. In addition, the thermal degradation process was further studied using the Py-GC/MS (pyrolysis-gas chromatography/mass spectrometry), TG (thermogravimetry), and DSC (differential scanning calorimeter) techniques. The outcomes of the Py-GC/MS, TG, and DSC techniques show that they have excellent thermal stability.