bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy and safety of metformin in combination with chemotherapy in cancer patients without diabetes: systematic review and meta-analysis
Authors: Yang Kang , Lu Hao-hao , Zhao Wei , Zhao Qingchun 
Published: July 2023

BackgroundThe results of a meta-analysis of retrospective studies suggest that the use of metformin in cancer patients may prolong progression-free disease survival and overall survival. However, the studies included in the meta-analysis did not strictly distinguish between patients with or without type 2 diabetes mellitus. Therefore, further studies are needed to assess whether the use of adjuvant chemotherapy with metformin in cancer patients without diabetes improves prognosis.MethodSystematic searches of Embase, Pubmed, and The Cochrane library were performed for the subject terms metformin and neoplasm and for free words. Data related to PFS, OS were extracted according to inclusion exclusion criteria. The data were combined and meta-analysis was performed using Review Manager 5.4 to confirm the efficacy and safety of metformin administration.ResultsThere were 3228 publications retrieved from the database and a total of 13 publications with 955 patients were included in the meta-analysis after screening. All included studies were randomised controlled trials. Metformin combined with adjuvant chemotherapy did not improve progression-free survival (HR=1,95CI 0.79-1.25), overall survival (HR=0.91,95% CI 0.69-1.20) and did not improve objective disease response rates in patients. There was no significant difference in grade 3-4 adverse reactions compared to placebo.ConclusionIn this meta-analysis of randomised controlled trial studies, we found that chemotherapy in combination with metformin in cancer patients without diabetes did not prolong progression-free survival and overall survival and improved disease control in patients, although there was no significant difference in terms of safety. More high-quality randomised controlled trials are needed in the future to confirm the in vivo anti-tumour activity and survival benefit of metformin.
Selection of hematopoietic stem cell transplantation for T-cell lymphoblastic lymphoma
Authors: Li Zhen , Zhang Binglei , Fan Xinxin , Gui Ruirui , Yu Fengkuan , Wang Juan , Zhang Yanli , Zhou Keshu , Liu Yanyan , Li Yufu , Ding Jing , Song Yongping , Zhou Jian 
Published: July 2023

BackgroundHematopoietic stem cell transplantation (HSCT) is an important treatment for T-cell lymphoblastic lymphoma/leukemia (T-LBL). To compare the efficacy and influencing factors of autologous hematopoietic stem cell transplantation (auto-HSCT) with those of allogeneic hematopoietic stem cell transplantation (allo-HSCT) from different donors for the treatment of T-cell lymphoblastic lymphoma/leukemia (T-LBL) and provide a basis for selection of appropriate transplant methods and donors.MethodsTo provide evidence of appropriate transplant methods for these patients, we retrospectively summarized the clinical characteristics of 75 T-LBL patients receiving HSCT at Henan Cancer Hospital between March 2012 and October 2021. Overall survival (OS), progression-free survival (PFS), cumulative incidence of relapse (CIR), non-relapse mortality (NRM), and related factors affecting efficacy were analyzed.ResultsThe 3-year CIR (39.9% vs 31.1%, P=0.745), 3-year PFS (60.1% vs 49.6%, P=0.434), and 3-year OS (62.8% vs 53.0%, P=0.450) were not significantly different between the auto-HSCT and allo-HSCT groups. However, the 3-year NRM was significantly higher in the allo-HSCT group (0% vs 27.2%, P=0.033). Multivariate analysis showed that the first complete remission (CR1) after HSCT was an independent influencing factor of higher OS (HR=2.498, P=0.029) and PFS (HR=2.576, P=0.016). The absence of mediastinal invasion in patients receiving HSCT was an independent influencing factor of better PFS (HR=2.977, P=0.029) and lower CIR (HR=4.040, P=0.027). With respect to the impact of donor source, the NRM in the unrelated donor (URD) and haploid donor (HPD) groups was significantly higher than that in the auto-HSCT group (P=0.021 and P=0.003, respectively), while there was no significant difference between matched sibling donors (MSD) and auto-HSCT. Compared with the MSD-HSCT group, the auto-HSCT group showed an increasing trend in 3-year CIR (39.9 ± 11.1% vs 32.6 ± 11.2%, P=0.697) and a lower trend in 3-year OS (62.8 ± 11.4% vs 64.4 ± 12.2%, P=0.929).ConclusionsHSCT is an effective consolidation treatment option for patients with T-LBL without mediastinal invasion and with CR1 before transplantation. For CR1 patients, auto-HSCT and MSD-HSCT are effective modalities for improving survival. In non-CR1 patients without an MSD, matched unrelated donors and haploidentical donor transplantations are the best treatment options to reduce relapse and improve prognosis.
Epidemiology of birth defects based on a birth defects surveillance system in southwestern China and the associated risk factors
Authors: Peng Zhenren , Wei Jie , Chen Biyan , Huang Xiuning , Song Pengshu , Liang Lifang , He Jiajia , Feng Baoying , Que Ting , Qin Jie , Xie Yu'an , Qiu Xiaoxia , Wei Hongwei , He Sheng 
Published: July 2023

BackgroundBirth defects (BDs) are associated with many potential risk factors, and its causes are complex.ObjectivesThis study aimed to explore the epidemiological characteristics of BDs in Guangxi of China and the associated risk factors of BDs.MethodsBDs data of perinatal infants (PIs) were obtained from the Guangxi birth defects monitoring network between 2016 and 2020. Univariate Poisson regression was used to calculate the prevalence-rate ratios (PRR) to explore the changing trends of BDs prevalence by year and the correlation between the regarding of characteristics of BDs (including infant gender, maternal age, and quarter) and BDs. Clinical characteristics of PIs with BDs and general characteristics of their mothers were documented, and Spearman correlation analysis was used to explore the potential associated risk factors of BDs.ResultsBetween 2016 and 2020, 44,146 PIs with BDs were monitored, with an overall BDs prevalence of 121.71 (95% CI: 120.58–122.84) per 10,000 PIs, showing a significant increase trend (PRR = 1.116, 95% CI: 1.108–1.123), especially the prevalence of congenital heart defects (CHDs) that most significantly increased (PRR = 1.300, 95% CI: 1.283–1.318). The 10 most common BDs were CHDs, polydactyly, congenital talipes equinovarus, other malformation of external ear, syndactyly, hypospadias, cleft lip with cleft palate, cleft lip, hemoglobin Bart's hydrops fetalis syndrome (BHFS), and congenital atresia of the rectum and anus. BDs were positively correlated with pregnant women's age (R = 0.732, P &lt; 0.01) and education level (R = 0.586, P &lt; 0.05) and having pre-gestational diabetes mellitus (PGDM)/gestational diabetes mellitus (GDM) (R = 0.711, P &lt; 0.01), while when the pregnant women had a family history of a dead fetus (R = −0.536, P &lt; 0.05) and a birth of a fetus with BDs (R = −0.528, P &lt; 0.05) were negatively correlated with BDs.ConclusionA significant increase in the prevalence of BDs was detected between 2016 and 2020 in Guangxi, especially the prevalence of CHDs that most significantly increased. Older maternal age, higher maternal education level, and having PGDM before pregnancy or GDM in early pregnancy were the risk factors for BDs.
Advance care planning among older adults of Moroccan origin: an interview-based study
Authors: Demirkapu Hakki , Hajji Redouan , Chater Brahim , De Maesschalck Stéphanie , Van de Block Lieve , De Vleminck Aline , Devroey Dirk 
Published: July 2023

BackgroundAdvance care planning (ACP) is rare among ethnic minorities for social, cultural, and religious reasons.AimTo explore advance care planning–related knowledge, experience, and perspectives among adults aged ≥65 years with Moroccan backgrounds in Belgium.MethodSemi-structured interviews were conducted in Darija (Moroccan Arabic). GPs in Brussels and Mechelen recruited participants. Data were analysed qualitatively using a combination of inductive and deductive thematic analysis techniques.ResultsThe 25 interviewees (average age 74 years) lacked ACP knowledge and had not discussed it with healthcare professionals. They had discussed burial and residential care wishes with relatives. After a brief explanation, most interviewees did not find ACP useful, mainly for religious reasons. After more extensive explanation with specific examples, they had fewer religious objections and were more willing to have ACP discussions with their GPs and/or relatives. The mentioned facilitators were GPs’ provision of information, children’s involvement in ACP discussions, and the desire to not be dependent on children. Barriers were a lack of knowledge, procrastination due to good health, lack of organization, and taboos regarding the discussion of illness and death, trust in one’s children to take over care and make decisions, and fear of worrying one’s children.ConclusionDespite an initial lack of knowledge about ACP, many older adults with Moroccan backgrounds were willing to talk about it after receiving information in their native language. GPs should facilitate ACP discussions for these patients, paying attention to individual needs and preferences.
The diabetes annual review in a postal box: a qualitative study exploring views of people with diabetes
Authors: Colley Jack , Dambha-Miller Hajira , Price Hermione 
Published: July 2023

BackgroundPeople with diabetes who do not attend their annual review appointments often have poorer glycaemic control and increased complication rates. A postal kit for self-collection of blood tests, urine samples, and anthropometric data may facilitate remote annual reviews and improve uptake.AimTo explore views on a postal kit for annual review among people with diabetes and to collaborate with people living with diabetes to design and expand the scope of an annual review postal kit.MethodWe conducted semi-structured interviews and focus groups with adults with type 1 and type 2 diabetes. Purposive sampling was used to ensure 50% of study invites went to infrequent attenders of annual review appointments. Transcripts were collated and analysed thematically.ResultsTwenty-two participants took part, including nine infrequent attenders. All infrequent attenders and the majority of regular attenders responded positively to a postal kit, with convenience being the most prominent value described. Concerns raised related to personal capability of self-collection and the accuracy of results. Participants were asked for suggestions to improve the kit. The most common themes related to communication; participants wanted clearer information regarding the purpose of each test; they wanted feedback of their results through either a website or app with tailored advice for each result; and they wanted to utilise the kit to communicate their priorities for discussion at future consultations.ConclusionPostal kits for annual reviews were well-received by people living with diabetes. Designed well, they have the potential to overcome far more than just the physical barriers to annual review attendance.
A concept mapping approach to assess factors influencing the delivery of community-based salon interventions to prevent cardiovascular disease and breast cancer among ethnically diverse women in south London
Authors: Zaman Maham , Goff Louise , L’Esperance Veline , Karamanos Alexis , de Vale Marjorie Lima , Ayis Salma , Curcin Vasa , Durbaba Stevo , Molokhia Mariam , Harding Seeromanie , Mernagh-iles Ashlyn 
Published: July 2023

BackgroundIn the UK, women from ethnically diverse and socioeconomically deprived groups are at increased risk of underdiagnosis of cardiovascular disease (CVD) and low uptake for breast cancer screening. Raising awareness for CVD and breast cancer screening in partnership with salons can improve early detection, management and uptake of screening facilitating women and the NHS.AimTo explore the perceptions of hair and beauty professionals in the UK on factors that could influence the ability of salons to promote a culturally adapted educational intervention to improve CVD and breast cancer awareness and screening.MethodConcept mapping is a multi-stage mixed methods participatory approach. Snowball sampling and dissemination of study information (online and face-to-face) among salon staff nationally was conducted. Participants were given a focus prompt ‘What would be some factors that can influence the ability of salons to deliver this service?’ and required to generate statements in response. Statements will be sorted into categories based on similarity and rated for importance and feasibility. Concept maps using multidimensional scaling and hierarchical cluster analyses will be produced.ResultsA total of 19 participants participated in the first stage. We will report on statements generated by participants, statement clusters and ratings for importance and feasibility. This will be depicted in a Go-Zone map that will show statements simultaneously rated in both importance and feasibility.ConclusionParticipatory approaches can support the development of educational community-based interventions aiming to establish partnerships between community assets and health systems for CVD and breast cancer awareness and prevention.
Emulating a Startup in a University - Everything but the Code
Authors: Wasserman Tony 
Published: July 2023

<p> This paper describes a series of courses in the MS program in Software Management at Carnegie Mellon’s Silicon Valley campus. Students identify product ideas and form 4-5 person teams around their ideas, working through them for two semesters. The class covers everything from ideation of product ideas through financial models for the envisioned company, including identification of the pain points faced by prospective users, the target market, customer validation of the product ideas, creation of a product roadmap, competitive analysis, estimation of engineering effort, strategies for marketing and sales, and financial models. This paper emphasizes those aspects of the courses related to product definition and product strategy.<em><strong> </strong></em></p>
Microbial profile of ultrasonic cleaner water
Authors: Wijaya Esther , Indrajanti Mirza , Nila Seri , Sharon Jesslyn , Sulistyorini J. FR 
Published: July 2023

It is necessary to clean glasses regularly. Glasses are often dirty due to attached dusts and contaminated microbe. Ultrasonic cleaner is often used effectively to clean the glasses. Therefore, the ultrasonic cleaner water contains contaminated microbe from glasses. This study aimed to identify bacteria and fungi yeast in the used ultrasonic cleaner water. For this study, glasses were cleaned with ultrasonic cleaner. Then, its water is inoculated at 3M Petrifilm for Escherichia coli, Staphylococcus aureus, and Candida albicans. The results showed that the most frequent Staphylococcus aureus and Candida albicans in the ultrasonic cleaner water. Escherichia coli was not often found. Since both of microbe, S. aureus and C.albicans are flora normal of the skin, it can be concluded that glasses are contaminated with these flora normal of the skin
EFFECT OF TREATMENT OF METABOLIC ACIDOSIS IN CHRONIC KIDNEY DISEASE (CKD) : A SYSTEMATIC REVIEW
Authors: Nur Amelia Devita 
Published: July 2023

Background: Plasma anions outweigh cations in metabolic acidosis. Metabolic acidosis may aggravate renal impairment. Sodium bicarbonate may help. Sodium bicarbonate in maintenance dialysis produces metabolic alkalosis. In chronic renal illness, sodium bicarbonate may worsen vascular calcifications. Aim: This article examines the link between effect of treatment of metabolic acidosis in chronic kidney disease (CKD). Methods: By evaluating the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) 2020 standards, this study demonstrated that it met all of the requirements. This enabled the researchers to ensure that the study was as up to date as feasible. Publications published between 2000 and 2023 were included in the search strategy, which included a variety of electronic reference databases (including Pubmed and SagePub). We did not consider review papers, duplicate publications, or half completed articles. Result: In the PubMed database, the results of our search brought up 388 articles, whereas the results of our search on SagePub brought up 201 articles. The results of the search conducted for the last year of 2013 yielded a total of 48 articles for PubMed and 22 articles for SagePub. In the end, we compiled a total of 25 papers, 17 of which came from PubMed and eight of which came from SagePub. We included eight research that met the criteria. Conclusion: The findings of the current investigation demonstrated that supplementation with alkali had a beneficial effect on preserving LBM and GFR in patients with CKD.
การเพิ่มประสิทธิภาพการบริหารศูนย์กระจายสินค้าเครื่องดื่มแอลกอฮอล์ และนอนแอลกอฮอล์ ศูนย์กลางวังน้อย จังหวัดอยุธยา
Authors: Thongsroy Sujin 
Published: July 2023

บทคัดย่อ
การวิจัยนี้มีวัตถุประสงค์ 1) เพื่อศึกษาอิทธิพลของการบริหารศูนย์กระจายสินค้าแอลกอฮอล์และนอนแอลกอฮอล์ที่มีต่อประสิทธิภาพของการปฏิบัติงานศูนย์กระจายสินค้า 2) เพื่อศึกษาประสิทธิภาพของการบริหารศูนย์กระจายสินค้า และ 3) เพื่อเสนอวิธีการปรับปรุงขั้นตอนการทำงานเพื่อเพิ่มประสิทธิภาพของศูนย์กระจายสินค้า ใช้รูปแบบการวิจัยแบบผสมระหว่างการวิจัยเชิงปริมาณและการวิจัยเชิงคุณภาพ เก็บข้อมูลโดยใช้แบบสอบถามกลุ่มตัวอย่างจำนวน 223 คน จากประชากร 533 คน ในศูนย์กระจายสินค้าวังน้อย จังหวัดอยุธยา จาก 4 แผนก คือ แผนกคลังสินค้า แผนกขนส่ง แผนกสินค้าคงคลัง และแผนกวางแผนกลาง และสัมภาษณ์เชิงลึก จำนวน 12 คน เครื่องมือวิจัยเป็นแบบสอบถาม 78 ข้อคำถาม ผ่านการตรวจสอบคุณภาพจากผู้เชี่ยวชาญ และแบบสัมภาษณ์เชิงลึก 14 ข้อ สถิติที่ใช้ในการวิเคราะห์ข้อมูล คือ สถิติเชิงพรรณนา และการวิเคราะห์การถดถอยพหุคูณ ผลการวิจัยพบวา 1) อิทธิพลของการบริหารศูนย์กระจายสินค้าแอลกอฮอล์และนอนแอลกอฮอล์ ได้แก่ การรับสินค้า การบริหารพื้นที่จัดเก็บสินค้า การเบิกสินค้า มีอิทธิพลต่อประสิทธิภาพของการปฏิบัติงานศูนย์กระจายสินค้า ขณะที่การจัดเก็บสินค้าและการจ่ายสินค้า นั้นกลับไม่มีผล 2) ระสิทธิภาพของการบริหารศูนย์กระจายสินค้า พบว่าเกิดจาก (2.1) วิธีการจัดการการเบิกสินค้าให้มีประสิทธิภาพ เช่น ในเอกสารใบเบิกสินค้าจะต้องระบุรายละเอียดสำคัญให้ชัดเจน เพื่อไม่ให้เกิดปัญหาเบิกสินค้าไม่ตรงเงื่อนไข (เช่น อายุสินค้า ประเภทพาเลทที่รองสินค้า) (2.2) วิธีการจัดการการเก็บสินค้า ให้เกิดประสิทธิภาพ เช่น การกำหนดให้พนักงานขับรถโฟร์คลิฟท์ ที่เก็บสินค้าต้องปฏิบัติให้ถูกต้องตามวิธีการทำงานเพื่อให้ข้อมูลสินค้าในโลเคชั่นถูกต้องกับระบบ (2.3) วิธีการจัดการการจ่ายสินค้า ให้มีประสิทธิภาพ เช่น กำหนดให้มีการตรวจสอบรายละเอียดที่ สำคัญของเอกสารให้ถูกต้อง ก่อนส่งมาให้พนักงานจ่ายสินค้า และ 3) เสนอวิธีการปรับปรุงขั้นตอนการทำงานเพื่อเพิ่มประสิทธิภาพของศูนย์กระจายสินค้า คือ จะต้องกำหนดวิธีปฏิบัติงานในด้านการเบิกสินค้าก่อนเป็นลำดับแรก จากนั้นตามด้วยวิธีปฏิบัติงานด้านการเก็บสินค้า และการจ่ายสินค้า ตามลำดับ จะช่วยในการเพิ่มประสิทธิภาพการดำเนินงานของศูนย์กระจายสินค้าในด้านความถูกต้อง ความตรงต่อเวลา ความพึงพอใจ ได้มากที่สุด

คำสำคัญ: การเพิ่มประสิทธิภาพ การบริหารศูนย์กระจายสินค้า เครื่องดื่มแอลกอฮอล์และนอนแอลกอฮอล์
ประเภทบทความ: บทความวิจัย
“The Curtain Rises on the Drama”
Authors: Wells Brandy Thomas 
Published: July 2023

Abstract
This article examines the National Council of Negro Women's (NCNW) participation in the founding conference of the United Nations. Moving beyond a focus on formal actors, it situates Mary McLeod Bethune, the organization's founder and president and the only African American woman to serve as an official representative, alongside her contemporaries on whom she relied. It argues that recovering the activism of Dorothy Boulding Ferebee, Eunice Hunton Carter, Sue Bailey Thurman, Anna Arnold Hedgeman, and a host of other Black women is to recognize a polity that, by all accounts, was not supposed to be present or active in San Francisco. These women's activities at the conference and in the decades that followed illuminate the broad contours of Black women's antisexist, antiracist, and anticolonial activism during the Second World War into the Cold War period. Akin to their efforts at the founding conference, this population's creative practices and cultural diplomacy reveal that the councilwomen maintained an enduring commitment to global freedom and the United Nations’ radical potential.
Pengaruh Blok Pleksus Servikal Superfisialis Menggunakan Levobupivakain Isobarik 0,25% Terhadap Hemodinamik, Kebutuhan Obat Anestesi, dan Intensitas Nyeri pada Pembedahan Regio Klavikula
Authors: Wibowo Anthony Hadi , Wahyudi  , Salahuddin Andi , Hisbullah  , Faisal  , Rum Muh 
Published: July 2023

Abstrak
Fraktur klavikula diperkirakan berkontribusi sekitar 15% dari fraktur ekstremitas atas. Fiksasi pembedahan dianjurkan untuk meningkatkan fungsi yang lebih baik. Multimodal analgesia adalah salah satu komponen kunci yang dianjurkan Procedure Specific Postoperative Pain Management (PROSPECT) untuk mendukung program Enhanced Recovery After Surgery (ERAS). Operasi regio klavikula umumnya dilakukan dalam anestesi umum atau dengan blok pleksus brachialis, namun blok seperti interscalene memiliki beberapa komplikasi berat seperti hemiparalisis diafragma, sindrom Horner, dan pneumothoraks. Blok pleksus servikalis superfisialis (PSS) terhindar dari komplikasi tersebut dan diharapkan dapat menjadi blok yang rutin dipakai untuk operasi daerah klavikula yang dikombinasi dengan anestesi umum. Tujuan penelitian ini adalah untuk mengetahui efek blok PSS terhadap hemodinamik, kebutuhan obat opioid, dan intensitas nyeri pada pasien operasi regio klavikula. Penelitian ini merupakan penelitian prospective randomized controlled trial dengan desain eksperimental. Sampel terdiri dari 2 kelompok, yaitu kelompok K (kelompok kontrol) dan B (kelompok dengan intervensi blok PSS) dengan jumlah sampel masing-masing 15 orang yang memenuhi kriteria inklusi. Dilakukan penilaian hemodinamik, penggunaan opioid, isofluran, NRS paska bedah, waktu rescue analgesia (WRA), dan rescue opioid paska bedah. Data dianalisis menggunakan uji statistik Mann-Whitney dan Wilcoxon, serta uji korelasi dengan uji Spearman. Hasil dari penelitian ini adalah hemodinamik yang lebih stabil, kebutuhan fentanil (p=0,001) dan isofluran (p<0,001) intraoperatif yang lebih rendah, NRS yang lebih rendah (p<0,001), dan tidak terdapat rescue pada kelompok blok (B). Blok PSS dapat mengurangi penggunaan obat anestesi, menurunkan intensitas nyeri, dan rescue opioid paska bedah pada pasien operasi regio klavikula.
Kata kunci: BPSS, fentanil, isofluran, NRS, rescue