bluuebunny/crossref_metadata_2025_split huggingface dataset:
963-P: Near-Infrared Device for Diabetes Screening—ANODE01 Study
Authors: CHOUDHARY PRATIK , LAZARO-PACHECO DANIELA , SALTER JOHN E. , PALDANIUS PAIVI M. 
Published: June 2023

Background: Diabetes mellitus (DM) screening is currently complex, inefficient and requires resource-intensive, invasive sampling. Development of affordable, rapid, and precise mass-screening tools is valuable in identifying the millions with undiagnosed DM, especially in lower income countries.
Materials and Methods: Accuracy and safety of a novel miniaturized full-spectrum near-infrared (NIR) spectroscopy device intended for DM screening was assessed in a multi-ethnic population with (n=50) or without (n=50) DM. Thirty NIR spectra scans per each middle fingernail and hand were tested for detection of dichotomised DM status based on cut-off values (&lt; HbA1c 6.5% or 6.0 ≥) and specificity (%) of chemometrics outcomes, in assessment of glycated nail keratin versus an HbA1c point-of-care assay as control.
Results: The cohort had mean age of 43.6 vs 64.4 years, 42 vs 76% females and 54 vs 68% Caucasians for non-DM and DM participants. Median (IQR) HbA1c % was 5.45 (5.2 - 5.6) and 6.8 (6.3-7.6), respectively. Clinical feasibility for NIR use was confirmed with no adverse device -related events reports for the over 6000 spectral measurements. The NIR-device demonstrated a specificity of 95.2% and 94.1% at HbA1c 6.5 and 6.0% cut-off levels, respectively (Table).
Conclusions: Our preliminary results indicate high specificity and potential for clinical implementation of non-invasive NIR technology in detection of those without immediate DM risk.

Disclosure
P.Choudhary: Advisory Panel; Medtronic, Novo Nordisk, Dexcom, Inc., MannKind Corporation, Insulet Corporation, Research Support; Abbott Diabetes, Speaker's Bureau; Sanofi, Lilly. D.Lazaro-pacheco: Consultant; Glyconics Ltd. J.E.Salter: None. P.M.Paldanius: Consultant; Glyconics Ltd, Speaker's Bureau; Novartis.

Funding
Glyconics
989-P: Glycaemic Control, Hypoglycaemia Unawareness, and Diabetes-Related Distress in Middle-Old (75 to 85 Years), and Old-Old (&gt;85) before and after Flash Glucose Monitoring in People Living with Diabetes—Association of British Clinical Diabetologist Study
Authors: DESHMUKH HARSHAL , WILMOT EMMA G. , WALTON CHRISTOPHER , RYDER ROBERT E. , SATHYAPALAN THOZHUKAT 
Published: June 2023

Introduction: There are limited data on the effect of intermittently scanned flash glucose monitoring (isCGM) on glycaemic control, hypoglycaemia unawareness and diabetes-related distress in middle-old (75 to 85 years) and old-old (≥85) people living with diabetes
Methods: Clinicians were invited to submit isCGM data to a secure web-based tool held within the National Health services N3 network. We collected baseline data before FSL initiation, such as patient demographics, glycated haemoglobin (HbA1c) values from the previous 12 months, Gold score and Diabetes Distress Screening scale (DDS2) score. We compared the baseline clinical characteristics across the age categories using a t-test. All the analyses were done in R 4.1.2.
Results: The study consisted of 16997 people with Type 1 diabetes with baseline and follow-up data, of which 342 were classified as middle-old, and 50 were classified as old-old (94% T1D). The use of isCGM was associated with significant improvement in Gold score in both middle-old (3.54 at baseline vs 3.02 at follow-up, P=0.04) and old-old populations (4.04 at baseline vs 2.72 at follow-up, P=0.01). The use of isCGM was also associated with significant improvement in DDS2 scores in both middle-old (2.53 at baseline vs 2.02 at follow-up, P&lt;0.001) and old-old populations (2.40 at baseline vs 1.73 at follow-up, P&lt;0.01). However, there was no significant effect of isCGM on glycaemic control in middle-old (64.2 mmol/mol at baseline vs 65.2 mmol/mol at follow-up, P=0.45) and old-old populations (60.3 mmol/mol at baseline vs 66.6 mmol/mol at follow-up, P=0.05).
Conclusion: The use of isCGM was associated with significant improvement in diabetes-related distress and hypoglycaemia unawareness in middle-old and old-old people living with diabetes but did not affect glycaemic control in this population.

Disclosure
H.Deshmukh: None. E.G.Wilmot: Advisory Panel; Abbott Diabetes, Dexcom, Inc., Eli Lilly and Company, Insulet Corporation, Medtronic, Novo Nordisk, Sanofi, Roche Diabetes Care, Embecta, Consultant; Springer Healthcare, Research Support; Abbott Diabetes, Diabetes UK, Insulet Corporation, Novo Nordisk, NIH - National Institutes of Health, Speaker's Bureau; Abbott Diabetes, Dexcom, Inc., Eli Lilly and Company, Insulet Corporation, Medtronic, Novo Nordisk, Sanofi, Ypsomed AG, Glooko, Inc. C.Walton: None. R.E.Ryder: Other Relationship; Novo Nordisk, Speaker's Bureau; GI Dynamics, BioQuest. T.Sathyapalan: Other Relationship; Novo Nordisk, Abbott Diabetes, Research Support; Abbott Diabetes, Novo Nordisk, Eli Lilly and Company.
999-P: Cost-Effectiveness of MiniMed 780G Therapy Compared with Multiple Daily Injections (MDI) with Intermittently Scanned Continuous Glucose Monitoring (isCGM) in People with Type 1 Diabetes (T1D)—A United States Perspective
Authors: KOMMAREDDI MALLIKA , WHERRY KAEL 
Published: June 2023

Objective: A simulation study assessed cost-effectiveness of the MiniMed 780G (MM780G) system compared to MDI paired with isCGM devices in people with T1D.
Methods: The IQVIA Core Diabetes Model was used to estimate complications, costs, and quality of life over patients’ lifetimes. Demographic and clinical characteristics were sourced from a 6-month randomized controlled trial (ClinicalTrials.gov, NCT04235504). The cohort had a mean±SD age of 41.5±11.6 years, was 46% male, and had an A1C of 9.0%±0.97% at baseline. The MM780G reduced A1C by 1.5±0.7% after 6 months, compared to a 0.2±0.8% reduction by MDI + isCGM. Rates of hypoglycemia and diabetic ketoacidosis were taken from the literature for the MDI + isCGM group and were assumed to be 50% lower in MM780G patients. Probabilistic sensitivity and scenario analyses were conducted to assess the impact of parameter uncertainty and model assumptions.
Results: Results from the base case indicate that MM780G was associated with increased quality-adjusted life expectancy (QALE) compared to MDI + isCGM (10.75±0.14 years for MM780G vs. 9.61±0.12 for MDI + isCGM), as well as increased costs ($544,509 ± $17,464 for MM780G vs. $438,551 ± $16,307 for MDI + isCGM). The incremental cost-effectiveness ratio (ICER) in the base case was $93,595 per QALE. The probabilistic sensitivity analysis indicates a 96.6% probability that MM780G is cost-effective compared to MDI + isCGM in T1D at a willingness-to-pay (WTP) threshold of $150,000 per QALE. The scenario, assuming a 25% treatment effect for hypoglycemia and diabetic ketoacidosis, found that MM780G was associated with an ICER of $128,990 per QALE, and a 70.5% probability of cost-effectiveness compared to MDI + isCGM at a WTP threshold of $150,000.
Conclusions: At a WTP threshold of $150,000, MM780G is cost-effective in T1D compared to MDI + isCGM.

Disclosure
M.Kommareddi: Employee; Medtronic. K.Wherry: Employee; Medtronic, Stock/Shareholder; Medtronic.
Modeling and optimization of biogas production in a batch bioreactor
Authors: Tina Kegl  , Eloisa Torres-Jimenez  
Published: June 2023

Ever increasing demands for renewable energy sources are the driving force for the development of waste management technologies such as anaerobic digestion (AD) technology. For AD process understanding and optimization the numerical simulations provide a useful tool. Therefore, in this work, the main attention is focused on the development of an efficient and stable optimization approach. The optimization procedure is coupled with a suitable mechanistically inspired self-developed BioModel. For BioModel calibration, a special procedure was developed which incorporates the used BioModel, a sensitivity analysis, and a gradient-based optimization algorithm. The results of numerical simulation, obtained by the AD of various animal manures in a batch lab-scale bioreactor, confirm the reliability of BioModel and the efficiency of the presented calibration procedure. Furthermore, the results of AD process optimization show that the biogas quantity and quality as well as energy used up for bioreactor heating can be improved essentially when amount of added bacteria, temperature and pH values are optimized properly.
Modelling Wind Turbine Power Curves based on Frank’s copula
Authors: M.A. Garcia-Vaca  , J.E. Sierra-García  , M. Santos  , R. Pandit  
Published: June 2023

In the study of wind turbines, one of the most relevant and useful indicators is the power curve. It has been shown to be of paramount importance in evaluating turbine performance and therefore reducing operation and maintenance (O&M) costs. Various techniques can be applied to model and obtain the shape of this curve, which relates the electrical power generated by a turbine to the wind speed. Statistical copulas are used in this paper, a tool used in other fields such as econometrics, and whose potential lies in its ability to capture the complex dependency between the variables involved. In particular, the Frank copula is applied to obtain a probabilistic model of the power curve of a wind turbine. This model is compared with the Gaussian Mixture Model, a technique widely used to obtain parametric probabilistic models. As a result of this comparison, it is observed that the Frank copula model fits the power curve of the wind turbine with greater precision and reliability, which would allow its use for prediction and fault detection.
Central and left division hepatectomies in two dogs
Authors: Fontes Gabrielle S. , Piegols Hunter J. , Lapsley Janis M. , Lumbrezer-Johnson Sarah J. , Hostnik Eric T. , Selmic Laura E. 
Published: June 2023

Abstract

OBJECTIVE
To describe the management of extensive hepatectomy in 2 dogs.

ANIMALS
A 10-year-old female intact mixed-breed dog (case 1) and an 11-year-old male castrated mixed-breed dog (case 2) were presented for surgical evaluation following diagnosis of a hepatic mass.

CLINICAL PRESENTATION, PROGRESSION, AND PROCEDURES
16 months before presentation, case 1 had undergone a left lateral liver lobectomy, which resulted in an incomplete resection of hepatocellular carcinoma. Both dogs underwent surgical excision of the liver mass.

TREATMENT AND OUTCOME
In case 1, surgery consisted of the removal of the remaining left medial lobe, as well as the central division. Case 2 received a complete left and central division hepatectomy. Histopathology confirmed a diagnosis of hepatocellular carcinoma in both dogs. Liver enzyme resolution and lack of tumor recurrence were confirmed with chemistry panel and abdominal ultrasonography in both dogs.

CLINICAL RELEVANCE
This case report describes, for the first time, the clinical management and outcome of extensive hepatectomy in 2 dogs. We propose that extensive hepatectomy, staged or synchronous, is possible in a clinical setting.
Computed tomography angiography aids in predicting resectability of isolated liver tumors in dogs
Authors: Smola Christopher , Schwartz Pamela , Caceres Ana , Kirsch Meghan , Pawenski Michael 
Published: June 2023

Abstract

OBJECTIVE
To assess the accuracy of CT angiography (CTA) in predicting resectability, degree of surgical difficulty, and individual factors that may impact resectability of isolated hepatic masses in dogs.

ANIMALS
Prospective study of 20 dogs with 21 isolated hepatic masses.

PROCEDURES
All CTAs and surgeries were performed between June 16, 2013, and November 30, 2016, at The Animal Medical Center in New York. Preoperative CTA images were evaluated by a board-certified surgeon (n = 2). A preoperative assessment was completed, documenting several predetermined factors aimed at predicting resectability of each mass and the degree of surgical difficulty. Resectability was divided into gross resectability and complete histologic excision. Following surgery, the surgeon completed a postoperative assessment documenting the intraoperative findings. Independently, a blinded board-certified radiologist analyzed the images and completed an identical preoperative assessment.

RESULTS
The radiologist was more accurate in lesion localization compared to the surgeon (P = .023). Seventeen (17/21) masses were grossly resectable in surgery. Two additional (2/21) masses that were deemed grossly resectable were incompletely excised on histopathologic analysis. Both the surgeon and radiologist were accurate in their prediction of gross resectability and complete excision. Major vascular involvement, multilobar involvement, and right-sided laterality negatively affected resectability. The surgeon was significantly more accurate in predicting the degree of surgical difficulty (κ = 0.50) when compared to the radiologist (κ = 0.38).

CLINICAL RELEVANCE
Preoperative CTA of isolated hepatic masses is useful in prediction of surgical difficulty and resectability, as well as identifying several factors that impact resectability.
Criminal Responsibility of the Perpetrator with Alternating Split Personality
Authors: Golonka Anna 
Published: June 2023

Abstract
The study is devoted to the issue of criminal liability of a perpetrator suffering from conversion identity disorders. Therefore, its aim is to highlight the dilemmas arising from a split personality disorder in the context of the insanity of the perpetrator of a prohibited act. Based on the example of Kenneth Bianchi (case study), the difficulties related to the diagnosis of this disorder and its consequences in relation to criminal liability are shown. In turn, the analytical-dogmatic method is used to consider the issue related to the recognition of these disorders as a specific category of causes of the condition referred to in Article 31 § 1 of the Polish Criminal Code. Regardless of this, the study also presents an approach to this issue that differs from that previously presented in the literature. The conclusions drawn on this basis also allow for filling a certain gap in the Polish literature on criminal law, which is a lack of studies on the subject matter.
Administrative Penalty Proceedings in the Light of the Proposed Changes to the Fiscal Penal Code
Authors: Tużnik Marta Roma 
Published: June 2023

Abstract
This study explores the assumptions of the Bill of 13 April 2022 amending the Act – Fiscal Penal Code and Certain Other Acts in the scope of administrative penalty ticket proceedings conducted in cases of fiscal petty offences. The primary focus of the analysis is the presentation of the proposed changes (ultimately withdrawn) regarding the extension of the catalogue of bodies authorised to conduct administrative penalty proceedings to include the Municipal Police and the Trade Inspection Authority, and to define their competence. Furthermore, the article presents the positions submitted by various entities as part of public consultations on the draft in question. The publication concludes with the author’s evaluation of the currently applicable legal regulations concerning the issue under discussion.
Disability Pension Granted Due to the Reduction of Prospects for Success in the Future
Authors: Mularski Krzysztof , Grzesiowski Krzysztof 
Published: June 2023

Abstract
The aim of this article is to interpret the conditions for, and the content of, a claim for an appropriate disability pension granted due to the reduction of prospects for success in the future (referred to as the third disability pension condition under Article 444 § 2 of the Civil Code). The chosen subject of analysis is primarily justified by the relative lack of attention this disability pension has received in legal literature compared to pensions granted due to other conditions specified in Article 444 § 2 CC. The authors focus on resolving some of the interpretative doubts in the civil law related to the phrase “reduction of the prospects for success in the future”. The derivative conception of legal interpretation serves as the foundation for their analyses. The article posits that a claim for a pension due to the reduction of prospects for success in the future is available to every natural person (including a conceived child) who has suffered a bodily injury or health disorder resulting in a loss of the ability to work (in the broad sense of the term), including the ability to perform household chores and, consequently, the material or financial benefits such work would provide. According to the authors, the provision’s apparent role is to resolve interpretative doubts regarding the pecuniary benefits that the aggrieved party would likely obtain in the future. This likelihood is higher than low or small, but lower than the probability bordering on certainty (or at least very high), which is the usual requirement for lost benefits in order to be granted a disability pension. This result of the interpretation is fully justified in both functional and systemic interpretative directives, as the legislator, to a certain extent, favours the interests of the person who suffered personal injury over those of the entity responsible for the damage.
New Procedure for Electronic Deliveries in Administrative Proceedings
Authors: Cebera Agata 
Published: June 2023

Abstract
This study focuses on the new procedure of electronic deliveries in administrative jurisdictional proceedings, as regulated by the provisions of the Code of Administrative Procedure. The primary research objective was to describe de lege lata the modes of individual deliveries, indicating their mutual hierarchy, while also addressing several issues related to the relationship between the Code and the Act on Electronic Deliveries. Both normative acts necessitate co-existence, and thus determining which of them and in which situational variants will be qualified as lex generali. This task is by no means facilitated by the fact that the characteristics of the framework regulation can be found in the Code, while the Act “model” regulates the rules of communication involving public entities. The main thesis presented in the study underscores the need for a systemic interpretation of the provisions of the latter Act. The author also believes that the definition of the scope of exclusions from the application of the Act was not designed appropriately. The issues raised have not been the subject of articles thus far.
Propaganda and the Web 3.0: Truth and ideology in the digital age
Authors: Hyzen Aaron 
Published: June 2023

ABSTRACT
The aim of this contribution is to elaborate on propaganda to better define the term in its constituent parts and to build a conceptual model that can also serve as a programme of study. To this end, I develop a definition of propaganda as the enforcement of ideological goals to manage public opinion. Next, I discuss the complex relationship between truth and propaganda positioned alongside mis- and disinformation and argue true information can be, and often is, used as propaganda. I argue the contextual environment can play an equal role to the message itself in the process of distribution, dissemination, and reproduction of propaganda, particularly in light of the technological developments of Web 3.0. I discuss the crucial role of repetition and stereotypes, alongside “hot” and “banal” propaganda in either long- or short-term use. Lastly, I discuss the relationship between propaganda and its audiences from a cyclical perspective, considering them in their reception and participating role in a propaganda campaign and the consequences of intended and unintended audiences.
“Once Again Into the Breach” of the Debate About “Polity” in Aristotle’s Political Teaching: Another Closer Look at Politics 4 Chapters 12 and 13
Authors: Bates Clifford Angell 
Published: June 2023

Abstract
This paper offers a reexamination of Aristotle’s Politics 4, chapter 12–13—the so-called account of polity or the mixed regime. Aristotle suggests that the forthcoming discussion delves into either the optimal governing system in general or the most prevalent form of governance across various cities. However, upon closer examination of Politics 4.12–13, a distinct perspective emerges. Working off the account of the meso (the middle) of Politics 4.11, in 12–13 we are not offered an account of the best practical regime, that is of a specific regime form. Instead, Aristotle presents an account on how regimes can achieve moderation and harmony—that is stability. So instead of an account of a specific regime type, we get an account of what moderates and stabilizes regimes generally.
The differences of the US Arctic policy in accordance with the National Security Strategies
Authors: Хазиева Р.Р. , Карпова Е.И. 
Published: June 2023

Стратегия национальной безопасности – один из важнейших документов в области обороны для любой страны, которая имеет такой документ. Такая стратегия отражает основные направления государства в отношении определенных регионов, определяет национальные интересы и угрозы, которые стоят на пути существования или развития государства и его народа. Возрастание интереса мирового сообщества к Арктическому региону в последние два десятилетия не может не отразиться на политике пяти арктических государств, среди которых находятся и Соединенные Штаты. Целью статьи является выяснение отведенной для Арктики роли в политике и безопасности США и ее изменение в течении последних двух десятилетий. В данной статье авторы рассматривают, как менялась политика Соединенных Штатов Америки в отношении Арктического региона в соответствии со Стратегиями национальной безопасности от 2000, 2002, 2006, 2010, 2015, 2017, 2022 гг. В ходе анализа текста документов был сделан вывод о том, что интерес к Арктике в первом десятилетии XXI в. для Соединенных Штатов угас, однако после 2007 г., когда Россия ясно дала понять миру о своем возвращении в Арктику путем экспедиции А. Н. Чилингарова и установки российского флага на дне Северного Ледовитого океана, Арктика начала приобретать все большее значение в политике США.
The National Security Strategy is one of the most important documents in the field of defense for any country that has such a document. Such a strategy reflects the main directions of the state in relation to certain regions, determines the national interests and threats that stand in the way of the existence or development of the state and its people. The growing interest of the world community in the Arctic region over the last two decades cannot but affect the policy of the five Arctic states, among which are the United States. The purpose of the article is to clarify the assigned role for the Arctic in the US politics and security and its changes over the past two decades. In this article the authors examine how the policy of the United States of America towards the Arctic region has changed in accordance with the National Security Strategies of 2000, 2002, 2006, 2010, 2015, 2017, 2022. During the analysis of the text of the documents it was concluded that interest in the Arctic in the first decade of the XXI century for the United States faded, but after 2007, when Russia made it clear to the world about its return to the Arctic through the A. N. Chilingarov expedition and the installation of the Russian flag at the bottom of the Arctic Ocean, the Arctic began to acquire increasing importance in the US politics.