bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between meningioma consistency and surgical outcomes
Authors: Shah Ishan , Chung Ryan S. , Liu Kevin , Cote David J. , Briggs Robert G. , Guerra Gage , Gomez David , Yang Max , Feng Jeffrey J. , Renn Alex , Shiroishi Mark S. , Hurth Kyle , Peterson Racheal , Zada Gabriel 
Published: January 2025

OBJECTIVE
Tumor consistency, or fibrosity, affects the ability to optimally resect meningiomas, especially with recent trends evolving toward minimally invasive approaches. The authors’ team previously validated a practical 5-point scale for intraoperative grading of meningioma consistency. The impact of meningioma consistency on surgical management and outcomes, however, has yet to be explored. This study aimed to determine associations between meningioma consistency and presenting symptoms, tumor characteristics, and postoperative outcomes.

METHODS
A total of 209 surgically resected meningiomas were intraoperatively assigned a consistency grade according to a previously validated 5-point scale, ranging from extremely soft, suctionable tumors (grade 1) to firm/calcified tumors (grade 5). Presenting symptoms, tumor characteristics, postoperative complications, and surgical outcomes for these patients were prospectively collected. Tumor consistency was analyzed in three categories (grades 1 and 2, grade 3, and grades 4 and 5), using ANOVA, chi-square or Fisher’s exact tests, and univariable logistic regression to evaluate associations between consistency and perioperative characteristics.

RESULTS
The study cohort included 209 patients, of whom 48 (23%) were males with a mean age of 55.0 ± 13.7 years. Meningioma consistency distribution was as follows: grades 1 and 2 (n = 23, 11.0%), grade 3 (n = 88, 42.1%), and grades 4 and 5 (n = 98, 46.9%). The majority of meningiomas were skull base tumors (n = 144, 68.9%). Higher-consistency tumors were associated with lower rates of gross-total resection (OR 0.24, 95% CI 0.13–0.46; p < 0.001), increased invasiveness (OR 4.73, 95% CI 1.53–14.60; p = 0.007), tumor recurrence following resection (OR 3.30, 95% CI 1.25–8.66; p = 0.016), reoperation (OR 3.08, 95% CI 1.16–8.14; p = 0.024), and increased complication rates (OR 2.08, 95% CI 1.05–4.15; p = 0.037). No significant associations were identified with preoperative symptoms, tumor size (mean 4.04 ± 1.50 cm), or duration of surgery (mean 4.26 ± 1.60 hours) (all p > 0.05).

CONCLUSIONS
Tumor consistency is associated with important meningioma characteristics and perioperative outcomes. A prior knowledge pertaining to meningioma consistency and tumor characteristics using advanced imaging is a priority and may provide surgeons with meaningful data to guide resection strategy and anticipate postoperative outcomes and complications.
A comprehensive multicenter analysis of clinical, molecular, and imaging characteristics and outcomes of H3 K27–altered diffuse midline glioma in adults
Authors: Sim Yongsik , McClelland Andrew C. , Choi Kaeum , Han Kyunghwa , Park Yae Won , Ahn Sung Soo , Chang Jong Hee , Kim Se Hoon , Gardner Sharon , Lee Seung-Koo , Jain Rajan 
Published: January 2025

OBJECTIVE
The objective was to comprehensively investigate the clinical, molecular, and imaging characteristics and outcomes of H3 K27–altered diffuse midline glioma (DMG) in adults.

METHODS
Retrospective chart and imaging reviews were performed in 111 adult patients with H3 K27–altered DMG from two tertiary institutions. Clinical, molecular, imaging, and survival characteristics were analyzed. Characteristics were compared between adult and 365 pediatric patients from a previous multicenter meta-analysis dataset. Cox analyses were performed to determine predictors of overall survival (OS) in adult patients.

RESULTS
The median (range) age of adult patients was 40 (18–75) years, and 64 males and 47 females were included. Adults had a higher male proportion (57.7% vs 45.3%, p = 0.023), lower proportion of histological grade 4 (41.4% vs 74.0%, p < 0.001), and different tumor locations (p < 0.001) compared with pediatric patients; adults commonly showed a thalamus location (41.5%) followed by the spinal cord (27.0%), whereas pediatric patients predominantly showed a pons location (64.9%). The OS of adults was longer than that of pediatric patients (30.3 vs 12.0 months, p < 0.001, log-rank test). Older age at diagnosis (HR 0.96, p = 0.001), histologically lower grade (HR 0.25, p = 0.003), and gross-total resection of nonenhancing tumor (HR 0.15, p = 0.003) were independent favorable prognostic factors.

CONCLUSIONS
Adult patients with H3 K27–altered DMG showed distinct clinical, histological, and imaging characteristics compared to pediatric counterparts, with a significantly better prognosis. The authors’ results suggest that aggressive surgery should be pursued when deemed feasible for better survival outcomes.
Risk factors of short-term poor functional outcomes and long-term durability of ruptured large or giant intracranial aneurysms
Authors: Fukuda Hitoshi , Hyohdoh Yuki , Kawada Kei , Sorimachi Takatoshi , Suzuki Kaima , Kurita Hiroki , Uezato Minami , Chin Masaki , Okada Kei , Nakatomi Hirofumi , Shiokawa Yoshiaki , Ishikawa Tatsuya , Kawamata Takakazu , Morioka Jun , Nakahara Ichiro , Shimamura Norihito , Ohkuma Hiroki , Ichihara Nao , Ueba Tetsuya , Ikawa Fusao 
Published: January 2025

OBJECTIVE
Aneurysmal subarachnoid hemorrhage (SAH) is associated with high morbidity and mortality rates. In particular, functional outcomes of SAH caused by large or giant (≥ 10 mm) ruptured intracranial aneurysms are worsened by high procedure-related complication rates. However, studies describing the risk factors for poor functional outcomes specific to ruptured large/giant aneurysms are sparse. In addition, high recurrence and rebleeding rates following treatment of such aneurysms remain a concern. This study aimed to clarify the specific risk factors for poor short-term outcomes and long-term durability of SAH due to ruptured large/giant intracranial aneurysms using a multicenter observational database in Japan.

METHODS
Data were obtained from 8 institutions participating in a multicenter repository of aneurysmal SAH in Japan. Among 5095 consecutive registered patients with SAH patients, 416 patients with SAH caused by ruptured large/giant (≥ 10 mm) saccular intracranial aneurysms were included. The authors investigated the risk factors for poor functional outcomes in patients with such aneurysms using multivariable analyses and subsequently investigated the interaction between these risk factors. The association between the treatment modality (direct surgery or endovascular therapy) and functional outcomes were finally analyzed using a propensity score–based method. The long-term durability of the treated aneurysms was evaluated by analyzing rebleeding.

RESULTS
Poor functional outcomes (modified Rankin Scale score ≥ 3) at discharge were observed in 251 (60.3%) patients. Increasing aneurysm size was significantly associated with poor functional outcomes (OR 1.13, 95% CI 1.04–1.22; p = 0.003) by a multivariable logistic regression analysis, and such negative effects were more prominent in younger patients, those with a good initial neurological grade, and those treated with direct surgery by interaction analyses. Propensity score–based analysis revealed that patients treated with endovascular therapy had a higher chance of better functional outcomes (OR 1.56, 95% CI 1.41–1.71; p = 0.03). Rebleeding 1 year after treatment was more frequent in the endovascular therapy (4.8%) than in the direct surgery (0.0%) group by survival analysis (p = 0.008, log-rank test).

CONCLUSIONS
Increasing aneurysm size was identified as a risk factor for poor functional outcomes after SAH due to large/giant aneurysms and was affected by the interaction with other conventional risk factors. Endovascular therapy was more likely to be associated with better short-term outcomes; however, a higher delayed rebleeding rate after 1 year was a concern.
Repetitive and extensive focused ultrasound–mediated bilateral frontal blood-brain barrier opening for Alzheimer’s disease
Authors: Ye Byoung Seok , Chang Kyung Won , Kang Sungwoo , Jeon Seun , Chang Jin Woo 
Published: January 2025

OBJECTIVE
Focused ultrasound (FUS)–mediated blood-brain barrier (BBB) opening is safe and potentially beneficial in patients with Alzheimer’s disease (AD) for the removal of amyloid-beta (Aβ) plaques. However, the optimal BBB opening intervals and number of treatment sessions for clinical improvement remain undefined. Therefore, the aim of this study was to evaluate the safety and benefits of repeated and more extensive BBB opening alone.

METHODS
In this open-label prospective study, 6 patients with AD were enrolled from June 2022 to July 2023. FUS-mediated BBB opening was performed three times at 2-month intervals targeting the bilateral frontal lobes. 18F-florbetaben positron emission tomography (FBB-PET) was performed before the first procedure and after the third procedure. Patients were administered neuropsychological and neuropsychiatric evaluations.

RESULTS
All 6 participants completed the study without any acute treatment-related adverse events. An extensive area of BBB opening (mean 43.1 cm3), more than twice as large as the opening volume (mean 20 cm3) in the authors’ previous study, was confirmed by contrast-enhanced MRI. FBB-PET scans demonstrated a 14.9-Centiloid average decrease in Aβ plaques in 4 of the 6 participants (67%), but the Aβ plaques increased in 2 participants after BBB opening, compared with baseline. No significant changes were observed in the Korean version of the Mini–Mental State Examination in either group. Caregiver-Administered Neuropsychiatric Inventory scores improved in 5 of 6 participants (83%), indicating an improvement in neuropsychiatric symptoms.

CONCLUSIONS
This study confirmed the safety and efficacy of more frequent and extensive bilateral frontal BBB opening over multiple sessions in patients with AD. Furthermore, this is the first clinical trial to demonstrate improvement in neuropsychiatric symptoms through BBB opening alone, without concurrent administration of antibody medications.
Awake, endoscopic lumbar interbody spinal fusion: 10 years of experience with the first 400 cases
Authors: Wang Michael Y. , Grossman Jay 
Published: January 2025

OBJECTIVE
Awake, endoscopic spinal fusion has been utilized as an ultra–minimally invasive surgery technique to accomplish the goals of spinal fixation, fusion, and disc height restoration. While many techniques exist for this approach, this series represents a single institution’s experience with a large cohort and the evolution of this method.

METHODS
The medical records of a consecutive series of 400 patients treated over a 10-year period were retrospectively reviewed. Endoscopic decompression, expandable intervertebral spacer deployment, and percutaneous screws were combined with liposomal bupivacaine to allow for the surgery to be performed without general endotracheal anesthesia (GETA) in the vast majority of cases. Clinical and radiographic postoperative results were reviewed with special attention to surgical complications, in particular dorsal root ganglion (DRG) irritation.

RESULTS
All patients underwent surgery successfully without conversion to an open operation. Their mean age was 69.1 ± 10.4 years, and 42% of the patients were male. A total of 509 levels were fused, with the most common indication being spondylolisthesis (67.5%). The mean operative time was 84.6 ± 31.4 minutes, the mean intraoperative blood loss was 98 ± 63 ml, and the mean hospital length of stay was 1.93 ± 1.1 nights. Overall, 4.3% of the patients underwent planned GETA due to comorbidities, and 2% were converted to GETA intraoperatively. Eighty percent of the patients experienced > 75% improvement in leg pain, and 52% experienced > 75% improvement in axial back pain. Complications included transient DRG irritation (23%), adjacent-level disease requiring reoperation (3.5%), inadequate decompression (2.3%), and nonunion (1.8%).

CONCLUSIONS
This large case series demonstrates that awake, endoscopic spinal fusion is a viable option with acceptable clinical and radiographic results in a select patient population. Meticulous attention to detail is required to limit the rate of DRG irritation, achieve interbody height restoration, and mitigate nonunions.
Penerapan Metode Silat-Qu (Satu Hari Lima Ayat Al-Qur’an) dalam Meningkatkan Kemampuan Menghafal Al-Qur’an di PP Tahfidzul Qur’an Al-Mulk Jember
Authors: Kiftiyah Khafidatul , Maghfiroh Muliatul 
Published: January 2025

Pondok Pesantren Tahfidzul Qur’an Al-Mulk Jember adalah lembaga yang berfokus pada pengajaran dan pembinaan hafalan Al-Qur’an, lembaga ini berupaya menyediakan metode bernama Silat-Qu(Satu Hari Lima Ayat Al-Qur’an) dengan tujuan untuk memudahkan para santri dalam proses hafalan dan memahami Al-Qur’an. Penelitian ini bertujuan untuk mendeskripsikan bagaimana penerapan Metode Silat-Qu (satu hari lima ayat Al-Qur’an) dalam meningkatkan kemampuan menghafal Al-Qur’an di PP Tahfidzul Qur’an (PPTQ) Al-Mulk Jember, peneliti juga ingin mengetahui faktor pendukung dan penghambat penerapan Metode Silat-Qu (satu hari lima ayat Al-Qur’an) dalam meningkatkan kemampuan menghafal Al-Qur’an di PP Tahfidzul Qur’an (PPTQ) Al-Mulk Jember. Peneitian ini menggunakan pendekatan kualitatif dengan jenis deskriptif. Melalui sumber data yang di dapat dari observasi, wawancara dan dokumentasi, serta menggunakan referensi dari buku, skripsi dan artikel terkait. Berdasarkan hasil penelitian menunjukkan bahwa: Metode Silat-Qu di PP Tahfidzul Qur’an Al-Mulk Jember dapat memudahkan santri jika istiqomah menghafal Al-Qur’an lima ayat setiap hari dan memiliki niat serta motivasi yang kuat. Selain itu, metode ini dapat meningkatkan kemampuan santri untuk mengidentifikasi posisi ayat di halaman Al-Qur’an baik disisi kanan maupun kiri dan bahkan dapat menyebut ayat Al-Qur’an hanya dengan menyebutkan nomor ayatnya; mengamati bacaan awal dan akhir; mengenali kalimat yang awal dari setiap ayat-nya; membiasakan membaca ulang 20 kali per ayat yang dikombinasikan teknik maju-mundur dan ganjil-genap; Serta mengintegrasikan sistem jari sebagai panduan hafalan yang mengoptimalkan memori kinestetik dan visual santri. Ada beberapa faktor pedukung yaitu sarana pembelajaran yang memadai seperti mushaf Al-Qur’an, buku ziyadhah dan riyadhah, buku Silat-Qu, kitab majmu' wadhifatul a'mal. Selain itu, dukungan penuh dari lembaga karena sesuai dengan tujuan lembaga yang memprioritaskan pendidikan Al-Qur'an, serta dilihat dari segi istiqomah muroja’ah, menjaga sholat malam, memperbanyak doa dan motivasi. Sedangkan, faktor penghambatnya yaitu beberapa santri yang belum lancar membaca Al-Qur'an dan mengalami kesulitan dalam menghafal. selain itu, kurangnya konsistensi dalam melakukan muraja'ah.
From Alt-text to Real Context: Revolutionizing image captioning using the potential of LLM
Authors: Vrajkumar Patel  , Aayush Modi  , Harsh Mistry  , Abhishesh Mishra  , Dr. Rocky Upadhyay  , Apoorva Shah  
Published: January 2025

The "From Alt-Text to Real Context" project harnesses the transformative capability of Meta Llama-3.2-11B-Vision-Instruct, thus unleashing an unprecedented image captioning system with advanced multimodal reasoning and attention mechanisms. These descriptions are richly contextual and domain-adaptive, moving them beyond the boundaries of traditional models. The platform has been constructed very carefully, keeping a heavy robust backend in Python (Flask/FastAPI) and an interactive frontend created in React.js for easier human interaction. With strong, advanced tools that include Hugging Face Transformers, OpenCV, NumPy, and Pandas, it shines for fine-tuning models, image preprocessing, and manipulation for particular, domain-specific customizations suited for a wide variety of applications from accessibility to e-commerce and education. The system generates alt-text and can perform complex image analysis and identify key features, providing more comprehensive scene descriptions. It is equipped with sentiment analysis to decipher emotive signals; it can provide critical metrics to quantify positive sentiment. This sophisticated AI system is built on the power of LLM outshines with zero-shot and multilingual capabilities and can also be utilized in tasks like image-based captioning and storytelling. Combining state-of-the-art AI, high adaptability, and great user-friendliness, this project raises new standards for contextual understanding, applicability in real-life scenarios, and image captioning.
Seasonality and age-related propensity of cats to occur bacterial urocystitis
Authors: Martyniv Yu. V. , Isera Ya. V. K 
Published: January 2025

Diseases of the urinary system are relevant for cats regardless of how they are kept. During the year, cats' bodies are prone to infectious diseases, but the degree of manifestation in different periods is different. Bacterial urocystitis in cats is caused by several factors, which include a decrease in the protective functions of the immune system, improper diet and housing conditions, complications of non-infectious pathologies, and subclinical bacteriuria. The seasonality of bacterial urocystitis, mainly when relapses characterize the disease, is essential for early detection and timely prevention. A calculated approach to determining the most susceptible age groups of cats and the seasonality of infectious urocystitis determines the patterns of the spread of this disease. Mathematical approaches to modeling the early increase in the frequency of bacterial urocystitis in cats will make it possible to limit the uncontrolled use of antibiotics. Retrospective analysis of microbiological urine test data of 34 cats diagnosed with bacterial urocystitis during 12 months from June 2023 to May 2024 in the conditions of the Zoolabix veterinary laboratory in Lviv. The results showed that 55.9 % of disease cases occur in autumn. It was established that the number of patients increased gradually starting in September. The highest level of incidence occurs in November and is 29.4 % of all cases, while in spring, it is only 5.9 %, which is 9.5 times less than the number of patients in the autumn period. Urethral and bladder infections in cats were diagnosed sporadically during the spring months. The analysis showed that among cats of different ages, the frequency of bacterial urocystitis increases in animals of geriatric age (44.1 %), while young animals get sick the least often (23.5 %).
Latihan Bernapas dengan Bibir Mengerucut (Pursed Lip Breathing) terhadap Saturasi Oksigen Pasien PPOK
Authors: Inayati Anik , Ayubbana Sapti , Dewi Nia Risa , Pakarti Asri Tri 
Published: January 2025

ABSTRACT Chronic obstructive pulmonary disease (COPD) is a common lung disease that causes limited airflow and breathing problems. COPD patients who undergo treatment generally experience a decrease in SPO2 <95% which can have a negative impact on the patient's condition. Companion therapy to help increase SPO2 can be done through breathing exercises. The purpose of this study was to determine the effect of pursed lip breathing (PLB) on SPO2 in COPD patients. This study was conducted using a quasi-experimental study with a non-randomized control group pretest posttest design, the sample used was 28 divided into intervention and control groups, each group consisting of 14 people. Data analysis was carried out using univariate and bivariate analysis. The results of the independent t-test analysis showed that pursed lip breathing exercises were proven to have an effect on increasing SPO2 in COPD patients (p-value 0.002), the difference in the mean SPO2 of the two groups was 1.214%. It is hoped that PLB exercises can be used as one of the companion therapies for COPD patients who experience decreased SPO2. Keywords: Pursed Lip Breathing, SPO2, COPD ABSTRAK Penyakit paru obstruktif kronik (PPOK) adalah penyakit paru-paru umum yang menyebabkan aliran udara terbatas dan masalah pernapasan. Pasien PPOK yang data menjalani perawatan umumnya mengalami penurunan SPO2 <95% yang dapat berdampak buruk pada kondisi pasien. Terapi pendamping untuk membantu meningkatkan SPO2 dapat dilakukan melalui latihan pernapasan. Tujuan penelitian ini yaitu mengetahui pengaruh pursed lip breathing (PLB) terhadap SPO2 pasien PPOK. Penelitian ini dilakukan menggunakan studi kuasi eksperimen dengan rancangan non randomized control group pretest posttest design, sampel yang dipergunakan sebanyak 28 terbagi dalam kelompok intervensi dan kontrol, masing-masing kelompok 14 orang. Analisa data dilakukan menggunakan analisis univariat dan bivariat. Hasil analisis independent t test menunjukkan bahwa latihan pursed lip breathing terbukti berpengaruh terhadap peningkatan SPO2 pasien PPOK (p-value 0,002), selisih rerata SPO2 kedua kelompok adalah sebesar 1,214%. Diharapkan latihan PLB dapat digunakan sebagai salah satu terapi pendamping bagi pasien PPOK yang mengalami penurunan SPO2. Kata Kunci: Pursed Lip Breathing, SPO2, PPOK
Rancang Bangun Sistem Rekomendasi Pencarian Indekos Pada Kecamatan Rappocini Berbasis Website
Authors: Qadri Muhammad , Amiruddin Amran , Tahir Tamus Bin , Kamaruddin Kamaruddin , Tamsir Tamsir , Rahman Fery Fadul , Fadillah Andi Nur 
Published: January 2025

Pencarian indekos menjadi tantangan bagi mahasiswa yang membutuhkan tempat tinggal di Kecamatan Rappocini. Meskipun terdapat banyak opsi, namun kesulitan dalam menemukan indekos yang sesuai dengan preferensi dan kebutuhan masih sering terjadi. Penelitian ini bertujuan untuk mengembangkan sebuah sistem rekomendasi pencarian indekos berbasis website. Metode ini memanfaatkan data historis dari pengguna lain untuk memberikan rekomendasi yang personal dan akurat. Data indekos, preferensi pengguna, serta informasi geografis Kecamatan Rappocini diintegrasikan dalam sistem untuk meningkatkan kualitas rekomendasi. Pengujian dilakukan menggunakan data pengguna simulasi dan data indekos sebenarnya. Hasil pengujian menunjukkan bahwa sistem rekomendasi yang dikembangkan mampu memberikan rekomendasi yang relevan dan membantu pengguna dalam pencarian indekos di Kecamatan Rappocini.
Carried Couples Participation in Online Business: A Study of Harmonious Family Formation
Authors: Nawa Azkiya Rahima 
Published: January 2025

The high divorce rate in Indonesia indicates a lack of harmony in the household. Divorce is motivated by various factors, the highest factor at this time is the dispute and quarrel factor and economic factors. This qualitative study includes field research (Field Research), data collection techniques with interviews, and documentation of women as housewives and online business owners in the Pujut sub-district, Central Lombok district, West Nusa Tenggara. The results showed that online business provides many positive impacts for housewives in the Pujut sub-district of Central Lombok, such as increasing income for daily needs, adding relationships and insights about business, reducing boredom, becoming more independent, and good time and financial management. In addition, the housewives also receive support from their spouses and families which has a big impact on their business, helping each other, participatory cooperation, fairness, and mutual benefit in developing the company so that it still exists today. This is in line with the principle of Mubadala, which emphasizes partnership or equality between men and women in life, especially family life.