bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of the Increase in Left Ventricular Mass on the Risk of Long-Term Cardiovascular Mortality: A Prospective Cohort Study
Authors: Bombelli Michele , Vanoli Jennifer , Facchetti Rita , Maloberti Alessandro , Cuspidi Cesare , Grassi Guido , Mancia Giuseppe 
Published: April 2023

Background:
Left ventricular hypertrophy (LVH) is an independent predictor of cardiovascular events, and evidence has been obtained that an increase of a normal left ventricular mass (LVM) or new-onset LVH over time augments cardiovascular outcomes.

Methods:
We addressed this issue in a sample of a general population at relatively low cardiovascular risk. We analyzed subjects with normal echocardiographic LVM enrolled in the PAMELA (Pressioni Arteriose Monitorate E Loro Associazioni) study to follow the increase of LVM over time and assess the prognostic impact of this change on the incidence of cardiovascular events (mean follow-up 18.5 years).

Results:

In 990 subjects with no LVH at baseline, there was a significant average increase of LVM (21.2%), LVMI
BSA
(18.9%), and LVMI
HT
(22.3%) more than 10 years later. About a quarter developed LVH. The LVMI
BSA
change exhibited an association with the cardiovascular risk mortality during the following 18.5 years, and the association remained significant after adjustment for confounders (hazard ratio, 1.2 [1.0–1.5]). Similar findings were obtained for LVM in absolute values or indexed for height. The association was seen in both genders, but the link with the cardiovascular risk was statistically significant in males only.

Conclusions:
Thus, although over 10 years, the LVM increase does not reach a LVH status, it is associated with an augmented cardiovascular mortality risk. This suggests that it might be important to consider periodical LVM assessment, even when LVM is within the normal range, to timely detect its increase and cope with the need of cardiovascular risk restratification.
The Globular Amphora Culture in the Eastern Baltic: New Discoveries
Authors: Piličiauskas Gytis , Skipitytė Raminta , Oras Ester , Lucquin Alexandre , Craig Oliver E. , Robson Harry K. 
Published: April 2023

Abstract
Until now, Šventoji in northwest Lithuania was considered the most northern site of the Neolithic Globular Amphora Culture (hereafter GAC; ca. 3400–2500 cal BC) in Europe. Recently, however, ceramics typologically resembling GAC ware were identified among the materials from the multi-period sites of Abora 1 and Iča in Latvia and further to the north from Tamula in southeast Estonia. Here we present the multi-disciplinary analyses of these ceramics, including their morphology, function and chronology, to ascertain whether they could represent sporadic migrations of GAC groups into the region or exchange and increasing social contacts with the indigenous hunter-gatherers during the period from ca. 3000–2600 cal BC. Overall, our results align with previous studies showing that GAC groups in the Eastern Baltic possibly reorientated their economy from animal husbandry towards fishing, as recently evidenced by the composition of zooarchaeological assemblages, and the organic residue analysis of ceramic vessels, which markedly differ from the GAC communities of Central Europe. Indeed, in several coastal and southern regions of Lithuania, it would appear that some GAC migrants replaced the indigenous Subneolithic forager groups, whilst in other areas, they had little to no impact on the local cultural and economic development.
Seasonal Tropical–Extratropical Teleconnections Originating from Tropical Rainfall Modes Independent of the Niño-3.4 Index in Northern Winters
Authors: Peng Peitao , Wang Wanqiu , Kumar Arun 
Published: April 2023

Abstract
This study, based on an analysis with observational and reanalysis data, highlights seasonal tropical–extratropical atmospheric teleconnections originating from tropical rainfall modes unrelated to the Niño-3.4 index for northern winters. The mode decomposition for tropical rainfall is done by first removing the Niño-3.4 index–related variability from the tropical rainfall and then applying rotated empirical orthogonal function (REOF) analysis to the residual. The corresponding teleconnection patterns are obtained by regressing global atmospheric fields against the time series of the rainfall modes. Analyses of the tropical heating–atmospheric circulation relationship indicate that the circulation anomalies corresponding to the rainfall modes are forced responses to the corresponding rainfall mode. The teleconnection patterns reveal some new features and show that some intrinsic midlatitude patterns can be triggered by tropical forcing with different rainfall patterns. Results from this study are relevant to seasonal climate attribution and prediction analyses and climate model evaluation. As an illustration, the teleconnections from the rainfall modes, together with that related to the Niño-3.4 index and linear trend, are applied to the attribution analyses for the global circulation anomalies of 2019/20 winter and the California dry condition during the strong El Niño winter of 2015/16. The overall impact of these modes in the period of 1980–2021 is also discussed.

Significance Statement
This study highlights the seasonal tropical–extratropical atmospheric teleconnections independent of the Niño-3.4 index using tropical rainfall modes for northern winters. The reason for using rainfall rather than SST in the mode decomposition is that rainfall represents vertically integrated latent heat, which is the direct forcing of the tropical atmosphere, while SST may have no definite relationship with rainfall in the Indo-Pacific warm pool region. The results of this study are applicable to the analysis of climate attribution and prediction and climate model evaluation, and further, may also have the potential to help improve seasonal climate forecasts.
ENSO Spread Caused by Uncertainties in Initial Condition and High-Frequency Perturbations in the Tropical Pacific
Authors: Lian Tao 
Published: April 2023

Abstract
Uncertainties both in the initial condition (IC) and surface wind high-frequency perturbations (HFPs) contribute to the prediction spread of El Niño–Southern Oscillation (ENSO), yet the relative roles of the two are hard to separate, mostly due to the nonlinearity in ENSO dynamics. In this study, we conducted two ensemble experiments using the CESM model to analyze the source of ENSO spread arising from the tropical Pacific. The HFPs were precluded using an online low-pass-filtering scheme in one experiment. Results showed that the uncertainty in ENSO prediction depends on both the IC and HFPs. By comparing simulations with and without HFPs, it is found that the predicted ENSO spread decreased in magnitude when HFPs are removed, especially in the first four prediction months. At integration time longer than that, the additional impact of HFPs cannot be detected on top of that of the uncertainty in IC. To the ENSO spread anomaly, we found that it is tightly associated with uncertainty in the sea surface temperature and surface wind in the central-eastern equatorial Pacific at the short integration time, and associated with the HFPs in the western equatorial Pacific at the long integration time. When the HFPs are removed, the precursor of the ENSO spread anomaly at the long lead time emerges in the northeastern tropical Pacific, the area where the Pacific meridional mode originates from. Our results indicate that the uncertainty in ENSO prediction depends primarily on IC, and the HFPs in the western equatorial Pacific play the secondary role.
Three-stage channel sprays carbon nanotubes onto carbon fibers surface, preparing high performance carbon fibers composites
Authors: Zhang Chuanqi , Shi Song , Gao Chenyu , Zhang Da , Bi Lansen , Wang Lintao , He Yan 
Published: April 2023

Carbon fibers composites performance strengthening through graft Carbon nanotubes is a research hotspot at present. Here, a method for rapidly and effectively dispersing and removing CNT aggregates during spraying the CNTs onto CFs surface by the three-stage channel is reported. The scanning electron microscopy image characterization results shows that the three-stage channel has a significant effect on the removal of CNTs aggregates, and the obtained p-CNTs has a good dispersion morphology. Under the same condition, p-CNTs@CFs/EP and CNTs@CFs/EP composites are prepared by the three-stage channel spraying and direct spraying method respectively. Compared with no treatment CFs composites (o@CFs/EP), the tensile, compressive and interlaminar shear strength and radial thermal conductivity (λ⊥) of the CNTs@CFs/EP are increased by 7%, 11%, 9% and 80% (2452.04 MPa, 1209.37 MPa, 89.30 MPa and 1.28 W/(m·K)), the p-CNTs@CFs/EP increased by 29%, 35%, 37% and 203% (2949.06 MPa, 1471.67 MPa, 112.37 MPa and 2.15 W/(m·K)), the CNTs@CFs/EP resistivity is 72.72 Ω·m, a 64% decrease, the p-CNTs@CFs/EP is 45.45 Ω·m, a decrease of 78%. This indicates that the CFs composites prepared by the three-stage channel spraying method has better performance than direct spraying and no treatment. This method provides a new idea for CFs composites performance strengthening.
The Prevalence and Characteristics of Children With Profound Autism, 15 Sites, United States, 2000-2016
Authors: Hughes Michelle M. , Shaw Kelly A. , DiRienzo Monica , Durkin Maureen S. , Esler Amy , Hall-Lande Jennifer , Wiggins Lisa , Zahorodny Walter , Singer Alison , Maenner Matthew J. 
Published: April 2023

Objectives: Autism spectrum disorder (autism) is a heterogeneous condition that poses challenges in describing the needs of individuals with autism and making prognoses about future outcomes. We applied a newly proposed definition of profound autism to surveillance data to estimate the percentage of children with autism who have profound autism and describe their sociodemographic and clinical characteristics. Methods: We analyzed population-based surveillance data from the Autism and Developmental Disabilities Monitoring Network for 20 135 children aged 8 years with autism during 2000-2016. Children were classified as having profound autism if they were nonverbal, were minimally verbal, or had an intelligence quotient <50. Results: The percentage of 8-year-old children with profound autism among those with autism was 26.7%. Compared with children with non–profound autism, children with profound autism were more likely to be female, from racial and ethnic minority groups, of low socioeconomic status, born preterm or with low birth weight; have self-injurious behaviors; have seizure disorders; and have lower adaptive scores. In 2016, the prevalence of profound autism was 4.6 per 1000 8-year-olds. The prevalence ratio (PR) of profound autism was higher among non-Hispanic Asian/Native Hawaiian/Other Pacific Islander (PR = 1.55; 95 CI, 1.38-1.73), non-Hispanic Black (PR = 1.76; 95% CI, 1.67-1.86), and Hispanic (PR = 1.50; 95% CI, 0.88-1.26) children than among non-Hispanic White children. Conclusions: As the population of children with autism continues to change, describing and quantifying the population with profound autism is important for planning. Policies and programs could consider the needs of people with profound autism across the life span to ensure their needs are met.
Fulminant myocarditis following SARS-CoV-2 mRNA vaccination rescued with venoarterial ECMO: A report of two cases
Authors: Vila-Olives Rosa , Uribarri Aitor , Martínez-Martínez María , Argudo Eduard , Bonilla Camilo , Chiscano Luis , Herrador Lorena , Gabaldón Alejandra , Irene Buera  , Vidal Maria , De la Iglesia Ana , Díaz Maria Ángeles , López Elena , Font Marta , Barrabés Jose A. , Riera Jordi , Ferreira-González Ignacio , Ferrer Ricard 
Published: April 2023

Introduction Cases of myocarditis after COVID-19 messenger RNA (mRNA) vaccines administration have been reported. Although the majority follow a mild course, fulminant presentations may occur. In these cases, cardiopulmonary support with venoarterial extracorporeal membrane oxygenation (V-A ECMO) may be needed. Results We present two cases supported with V-A ECMO for refractory cardiogenic shock due to myocarditis secondary to a mRNA SARS-CoV2 vaccine. One of the cases was admitted for out-of-hospital cardiac arrest. In both, a peripheral V-A ECMO was implanted in the cath lab using the Seldinger technique. An intra-aortic balloon pump was needed in one case for left ventricle unloading. Support could be successfully withdrawn in a mean of five days. No major bleeding or thrombosis complications occurred. Whereas an endomyocardial biopsy was performed in both, a definite microscopic diagnosis just could be reached in one of them. Treatment was the same, using 1000mg of methylprednisolone/day for three days. A cardiac magnetic resonance was performed ten days after admission, showing a significant improvement of the left ventricular ejection fraction and diffuse oedema and subepicardial contrast intake in different segments. Both cases were discharged fully recovered, with CPC 1. Conclusions COVID-19 vaccine-associated fulminant myocarditis has a high morbidity and mortality but presents a high potential for recovery. V-A ECMO should be established in cases with refractory cardiogenic shock during the acute phase.
Efficacy of surgical treatment in patients with trigeminal neuralgia secondary to multiple sclerosis: A prospective study of 18 cases with evaluation of outcome and complications by independent evaluators
Authors: Worm Jacob , Noory Navid , Smilkov Emil Andonov , Heinskou Tone Bruvik , Andersen Anne Sofie Schott , Springborg Jacob Bertram , Rochat Per , Frederiksen Jette Lautrup , Bendtsen Lars , Maarbjerg Stine 
Published: April 2023

Introduction Medical treatments for trigeminal neuralgia secondary to multiple sclerosis have low efficacy and tolerability and scientific evidence regarding efficacy of neurosurgery is scarce. We aimed to assess neurosurgical outcome and complications in trigeminal neuralgia secondary to multiple sclerosis. Methods Patients with trigeminal neuralgia secondary to multiple sclerosis who underwent microvascular decompression, glycerol rhizolysis or balloon compression were prospectively and consecutively included from 2012 to 2019. Preoperatively, we systematically obtained clinical characteristics and performed a 3.0 Tesla MRI. Follow-up at three, six and 12 months was performed by independent assessors. Results We included 18 patients. Of the seven patients treated with microvascular decompression, two patients (29%) had an excellent outcome (both had neurovascular contact with morphological changes), three patients (43%) had a good outcome, one patient (14%) had treatment failure and one patient (14%) had a fatal outcome. Three patients (43%) had major complications. Of 11 patients treated with percutaneous procedures, seven patients (64%) had an excellent or good outcome with major complications in three patients (27%). Conclusion Percutaneous procedures provided acceptable outcome and complication rates and should be offered to the majority of patients with trigeminal neuralgia secondary to multiple sclerosis who need surgery. Microvascular decompression is less effective and has a higher complication rate in trigeminal neuralgia secondary to multiple sclerosis compared to microvascular decompression in classical and idiopathic trigeminal neuralgia. Microvascular decompression should only be considered in patients with trigeminal neuralgia secondary to multiple sclerosis when they have neurovascular contact with morphological changes.
Inflation and Its Uncertainty: Evidence from Indonesia and the Philippines
Authors: Kuncoro Haryo 
Published: April 2023

This article investigates the relationship between inflation and its uncertainty under the inflation-targeting regime in Indonesia and the Philippines over 2005(7)–2021(12). The Kernel density function and entropy index applications reveal that the price level in both countries is heterogeneous. The non-linear quantile regression estimation shows that inflation affects inflation uncertainty positively. Inflation more likely induces its uncertainty in higher quantiles. The effect exhibits an inconsistent linearity property. While the symmetric behavior holds in the Philippines, inflation in the case of Indonesia affects the inflation uncertainty differently, not only inter-quantiles but also intra-quantiles. Given that Indonesia and the Philippines have low inflation rates relative to other emerging markets, our findings suggest that announcing higher inflation targets may be costly to provoke higher inflation uncertainty. Accordingly, controlling inflation uncertainty in the inflation-targeting regime can be achieved if monetary policy is credible and independent. JEL Classification C14, C21, D08, E31, O23
Comparison of Superior Semicircular Canal Bone Thickness and Patterns in Unilateral and Bilateral Cleft Patients and Normal Controls: A CBCT Study
Authors: Paknahad Maryam , Karimnezhand Khas Reyhaneh , Hasani Mahvash 
Published: April 2023

Superior Semicircular Canal Dehiscence (SSCD) is a recently-defined developmental defect may be associated with several craniofacial anomalies such as Cleft Lip/Palate (CLP). The present study aimed to compare subjects with unilateral and bilateral CLP and normal controls in terms of Superior Semicircular Canal (SSC) bone thickness and pattern. A total of 238 Cone Beam Computed Tomography (CBCT) images were collected from 52 unilateral Cleft Lip and Palate (UCLP) subjects (104 temporal bones) and 38 Bilateral Cleft Lip and Palate (BCLP) (76 temporal bones) subjects and 148 healthy controls (296 temporal bones). The SSC bone thickness was measured twice and validated by a maxillofacial radiologist. The samples were then classified into five categories based on bone thickness: papyraceous or thin, normal, thick, pneumatized, and dehiscence. After all, the UCLP, BCLP, and normal control groups were compared concerning the SSC pattern and thickness. The results revealed no significant difference among the three groups regarding the SSC pattern and thickness based on gender. The SSC patterns ( P value = .001) and SSC thickness (0.01) were strongly correlated to the cleft type. The thinnest bone thickness and the highest incidence of SSCD were observed among the subjects with BCLP. The results showed a significant association between the SSC patterns and SSC thickness and the study groups.
Prescription Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) and Incidence of Depression Among Older Cancer Survivors With Osteoarthritis: A Machine Learning Analysis
Authors: Shaikh Nazneen Fatima , Shen Chan , LeMasters Traci , Dwibedi Nilanjana , Ladani Amit , Sambamoorthi Usha 
Published: April 2023

ObjectiveS: This study examined prescription NSAIDs as one of the leading predictors of incident depression and assessed the direction of the association among older cancer survivors with osteoarthritis. Methods: This study used a retrospective cohort (N = 14, 992) of older adults with incident cancer (breast, prostate, colorectal cancers, or non-Hodgkin’s lymphoma) and osteoarthritis. We used the longitudinal data from the linked Surveillance, Epidemiology, and End Results -Medicare data for the study period from 2006 through 2016, with a 12-month baseline and 12-month follow-up period. Cumulative NSAIDs days was assessed during the baseline period and incident depression was assessed during the follow-up period. An eXtreme Gradient Boosting (XGBoost) model was built with 10-fold repeated stratified cross-validation and hyperparameter tuning using the training dataset. The final model selected from the training data demonstrated high performance (Accuracy: 0.82, Recall: 0.75, Precision: 0.75) when applied to the test data. SHapley Additive exPlanations (SHAP) was used to interpret the output from the XGBoost model. Results: Over 50% of the study cohort had at least one prescption of NSAIDs. Nearly 13% of the cohort were diagnosed with incident depression, with the rates ranging between 7.4% for prostate cancer and 17.0% for colorectal cancer. The highest incident depression rate of 25% was observed at 90 and 120 cumulative NSAIDs days thresholds. Cumulative NSAIDs days was the sixth leading predictor of incident depression among older adults with OA and cancer. Age, education, care fragmentation, polypharmacy, and zip code level poverty were the top 5 predictors of incident depression. Conclusion: Overall, 1 in 8 older adults with cancer and OA were diagnosed with incident depression. Cumulative NSAIDs days was the sixth leading predictor with an overall positive association with incident depression. However, the association was complex and varied by the cumulative NSAIDs days.
Early Changes of Serum Interleukin 14α Levels Predicts the Response to Anti-PD-1 Therapy in Cancer
Authors: Wang Buhai , Chen Caiyue , Jiang Shiyu , Huang Yuxiang , Zeng Yichun , Li Lei , Wang Maoqi , Guo Jingliang , Li Qiuxian , Cao Jin , Shen Long , Gu Juan J , Liang Yichen 
Published: April 2023

Background: Programmed cell death-1 (PD-1) blockade has been shown to confer clinical benefit in cancer patients. Here, we assessed the level of serum interleukin 14α (IL14α) in patients receiving anti-PD-1 treatment. Methods: This prospective study recruited 30 patients with advanced solid cancer who received pembrolizumab treatment in Northern Jiangsu People’s Hospital between April 2016 and June 2018. The western blot analysis was used to assess the expression level of serum IL14α in patients at baseline and after 2 cycles of treatment. Interleukin 14α was performed using the unpaired 2-tailed Student test. The progression-free survival (PFS) and overall survival (OS) were calculated using the Kaplan-Meier method and compared by the log-rank test. Results: The early change of IL14α after 2 cycles of anti-PD-1 therapy was calculated as delta IL14α % change = (IL14α level after 2 cycles − IL14α level before treatment)/IL14α level before treatment × 100%. Receiver operating characteristic (ROC) was analyzed to get a cutoff point of delta IL14α % change as 2.46% (sensitivity = 85.71%, specificity = 62.5%; area under the ROC curve [AUC] = 0.7277, P = .034). Using this cutoff to subgroup the patients, an improved objective response rate was observed in patients with a delta IL14α change higher than 2.46% ( P = .0072). A delta IL14α change over 2.46% was associated with a superior PFS ( P = .0039). Conclusions: Early changes of serum IL14α levels may be a promising biomarker to predict outcomes in patients with solid cancer following anti-PD-1 treatment.