bluuebunny/crossref_metadata_2025_split huggingface dataset:
Surgical treatment of caseous calcification of the mitral annulus causing mitral stenosis and mimicking the clinical picture of infective endocarditis: A case report
Authors: Kahraman Nail , Topal Dursun , Coşkun Gültekin , Tiryakioğlu Selma Kenar , Topal Serra , Güler Sena , Binicier Nöfel Ahmet , Koca Fatih , Demir Deniz 
Published: March 2023

AbstractAmong masses involving the mitral valve and annulus, caseous calcification of the mitral annulus (CCMA) is a rare disease. CCMA accounts for .63% of all mitral annular calcification (MAC) cases. The pathophysiology is still unknown. The correct diagnosis and treatment of this disease is very important to prevent complications. We present a case of giant CCMA with advanced mitral stenosis and hypertrophic cardiomyopathy, presenting with symptoms of infection and therefore a preliminary diagnosis of infective endocarditis. Because of these features, we wanted to share our case as it is the 1st case in the literature.
Myelination dictates axonal viscoelasticity
Authors: Chuang Ya‐Chen , Alcantara Ace , Fabris Gloria , Abderezaei Javid , Lu Tse‐An , Melendez‐Vasquez Carmen V. , Kurt Mehmet 
Published: March 2023

AbstractDuring development, dramatic changes in myelination, growth of neural networks and changes in grey‐to‐white matter ratio build up the astonishingly plastic brain of a child. The progressive increase in myelination insulates the nervous system, which, in turn, modifies the mechanical microenvironment of the brain spatiotemporally. A growing body of evidence demonstrates the role of mechanical forces in growth, differentiation, maturation and electrical properties of neurons. However, due to limitations in imaging resolution, the exact relationship between myelination, axonal organization and the mechanical properties of nerves at the cellular level is still unknown. Here, we propose a novel approach to study the direct relationship between axonal viscoelasticity with changing fibre anisotropy and myelination during development. With the use of atomic force microscopy (AFM) with in situ fluorescent imaging of the primary neuron‐oligodendrocyte co‐cultures, we found that as axons are progressively myelinated in vitro, their stiffness increases. Direct quantification of myelin along axons using immunofluorescence also demonstrated a positive correlation between increased myelination over time and increased axonal stiffness (p = .001). Notably, AFM measurements along a single axon showed that the Young's modulus measured across myelinated regions were significantly higher than those of adjacent unmyelinated segments at all time points (p < .0001). Force‐relaxation analysis also demonstrated that myelin sheath dominates the regulation of viscoelasticity of axons temporally. Collectively, our findings indicate a direct link between myelination, axonal orientation and viscoelasticity, providing important insights about the mechanical environment in the paediatric brain, with direct implications for our understanding of developmental brain disorders and paediatric brain injury.
Type I spinal muscular atrophy patients treated with nusinersen: 4‐year follow‐up of motor, respiratory and bulbar function
Authors: Pane Marika , Coratti Giorgia , Sansone Valeria A. , Messina Sonia , Catteruccia Michela , Bruno Claudio , Sframeli Maria , Albamonte Emilio , Pedemonte Marina , Brolatti Noemi , Mizzoni Irene , D'Amico Adele , Bravetti Chiara , Berti Beatrice , Palermo Concetta , Leone Daniela , Salmin Francesca , De Sanctis Roberto , Pera Maria Carmela , Piastra Marco , Genovese Orazio , Ricci Federica , Cavallina Ilaria , Masson Riccardo , Zanin Riccardo , Agosto Caterina , Salomon Eleonora , Bruno Irene , Magnolato Andrea , Bertini Enrico , Tiziano Francesco Danilo , Bovis Francesca , Mercuri Eugenio ,   the Italian EAP Working Group
Published: March 2023

AbstractBackgroundWe report the 4‐year follow‐up in type I patients treated with nusinersen and the changes in motor, respiratory and bulbar function in relation to subtype, age and SMN2 copy number.MethodsThe study included SMA 1 patients with at least one assessment after 12, 24 and 48 months from the first dose of nusinersen. The assessments used were Children's Hospital of Philadelphia Infant Test of Neuromuscular Disorders (CHOP INTEND) and the Hammersmith Infant Neurological Examination (HINE‐II).ResultsForty‐eight patients, with ages ranging from 7 days to 12 years (mean 3.3 years, SD 3.6 years) were included in the study. The CHOP INTEND and HINE‐II scores significantly increased between baseline and 48 months (p < 0.001). When age at starting treatment subgroups (<210 days, <2 years, 2–4 years, 5–11 years, ≥12 years) were considered, the CHOP INTEND increased significantly in patients younger than 4 years at treatment, while the HINE‐2 increased significantly in patients younger than 2 years at treatment. In a mixed‐model analysis, age, nutritional and respiratory status were predictive of changes on both scales while SMN2 copy number and decimal classification were not.ConclusionsOur results confirm the safety profile previously reported and support the durability of the efficacy of nusinersen at 4 years with an overall stability or mild improvement and no evidence of deterioration over a long period of time.
Parental support influencing the timing of repeat pregnancy for adolescent mothers
Authors: Norton Jessica R. , Yildirim Elif Dede , Duke Adrienne M. , Moss Regan 
Published: March 2023

AbstractObjectiveThis study examined the relationship between parental support and the timing of adolescent mothers' repeat pregnancies.BackgroundShort interpregnancy timing during adolescence, or an early repeat pregnancy, is a concerning outcome for adolescent mothers because they exacerbate the previous and ongoing adversities of adolescent mothers. Although social support tends to be positive for parenting and well‐being, it is unclear whether social support is protective for when adolescent mothers experience a repeat pregnancy. Parents are the primary source of support for adolescent mothers; thus, it is important to examine their influence on adolescent mothers' experience(s) of repeat pregnancy.MethodsSemi‐Markov multistate models were applied to 20 years of data to examine the relationship between support and timing and risk of subsequent pregnancies for 471 adolescent mothers in the National Longitudinal Study of Youth 1997.ResultsThis study found that emotional and financial support from parents predicts a higher likelihood of delayed repeat pregnancies, whereas informational support from parents predicts earlier repeat pregnancies for adolescent mothers.ConclusionThe effects of parental support are multifaceted and appear to differentially influence when adolescent mothers experience repeat pregnancies.ImplicationsUnderstanding how parental support influences when adolescent mothers experience repeat pregnancy can inform programs that aim to strengthen family support for pregnant and parenting youth.
The essential role of biodiversity in the key axes of ecosystem function
Authors: Yan Pu , Fernández‐Martínez Marcos , Van Meerbeek Koenraad , Yu Guirui , Migliavacca Mirco , He Nianpeng 
Published: March 2023

AbstractBiodiversity is essential for maintaining the terrestrial ecosystem multifunctionality (EMF). Recent studies have revealed that the variations in terrestrial ecosystem functions are captured by three key axes: the maximum productivity, water use efficiency, and carbon use efficiency of the ecosystem. However, the role of biodiversity in supporting these three key axes has not yet been explored. In this study, we combined the (i) data collected from more than 840 vegetation plots across a large climatic gradient in China using standard protocols, (ii) data on plant traits and phylogenetic information for more than 2,500 plant species, and (iii) soil nutrient data measured in each plot. These data were used to systematically assess the contribution of environmental factors, species richness, functional and phylogenetic diversity, and community‐weighted mean (CWM) and ecosystem traits (i.e., traits intensity normalized per unit land area) to EMF via hierarchical partitioning and Bayesian structural equation modeling. Multiple biodiversity attributes accounted for 70% of the influence of all the variables on EMF, and ecosystems with high functional diversity had high resource use efficiency. Our study is the first to systematically explore the role of different biodiversity attributes, including species richness, phylogenetic and functional diversity, and CWM and ecosystem traits, in the key axes of ecosystem functions. Our findings underscore that biodiversity conservation is critical for sustaining EMF and ultimately ensuring human well‐being.
Device‐mediated customer behaviour on the internet: A systematic literature review
Authors: Wolf Lukas 
Published: March 2023

AbstractThe proliferation of smartphones, tablets and other digital devices in addition to traditional computers has transformed the Internet into a device‐mediated environment. While these devices provide immediate access to similar Internet sources, they differ significantly in their characteristics, such as screen size, operation mode and context of use. As a consequence, behaviours on the Internet along the customer journey vary substantially depending on the device used. To summarize the fast‐growing body of research on device‐mediated customer behaviour, a systematic, framework‐based literature review of 59 articles from the last decade was conducted. Through an examination of the antecedents, decisions and outcomes investigated in the publications, the review presents a conceptual framework that highlights the relation between device characteristics, decision processes and behavioural outcomes. The review further summarizes the theories, contexts and methods employed in the studies and sets an extensive future research agenda. We found that the extant literature lacks comprehensive theories and clear definitions of digital devices in the omnichannel environment. Furthermore, existing findings should be generalized for other contexts (e.g. industries and countries) and validated via the introduction of other research designs and methods. The understanding of device‐mediated behaviour and the consequently arising marketing measures remains scarce. Thus, this review advances the comprehension of customer behaviour on the Internet and provides researchers and practitioners with information on the implications for customer experience and omnichannel management.
Reappraisal and updated review of maggot debridement therapy in chronic lower extremity ulcers
Authors: Shamloul Gelan , Khachemoune Amor 
Published: March 2023

AbstractBackgroundDating back to the mid‐1500s, maggot debridement therapy (MDT) has been a viable treatment modality for chronic wounds. In early 2004, the sterile larvae of Lucilia sericata received FDA approval for medical marketing for neuropathic, venous, and pressure ulcers, traumatic or surgical wounds, and nonhealing wounds that have not responded to standard care. However, it currently remains an under‐utilized therapy. The proven efficacy of MDT begs the question if this treatment modality should be considered as a first‐line option for all or a subset of chronic lower extremity ulcers.ObjectiveThis article aims to address the history, production, and evidence of MDT and discuss future considerations for maggot therapy in the healthcare field.MethodsA literature search using the PubMed database was conducted using keywords, such as wound debridement, maggot therapy, diabetic ulcers, venous ulcers, among others.ResultsMDT reduced short‐term morbidity in non‐ambulatory patients with neuroischemic diabetic ulcers and comorbidity with peripheral vascular disease. Larval therapy was associated with statistically significant bioburden reductions against both Staphylococcus aureus and Pseudomonas aeruginosa. Faster time to debridement was achieved when chronic venous or mixed venous and arterial ulcers were treated with maggot therapy versus hydrogels.ConclusionsThe literature supports the use of MDT in decreasing the significant costs of treating chronic lower extremity ulcers, with emphasis on those of diabetic origin. Additional studies with global standards for reporting outcomes are necessary to substantiate our results.
Scoping of advanced clinical practitioner role implementation using national job advertisements: Document analysis
Authors: Snaith Beverly , Sutton Claire , Partington Sarah , Mosley Elizabeth 
Published: March 2023

AbstractAimThe aim of this study is to profile the contemporary advanced clinical practitioner (ACP) role through standardized document sets.DesignDocumentary analysis of job descriptions (JDs), person specification and advertisements.Data SourcesEngland based jobs advertised on NHS jobs website from 22 January to 21 April 2021.ResultsA toatal of 143 trainee and qualified ACP roles were identified. A wide range of sectors and specialities were represented from across all English regions. The most common roles were urgent care, emergency medicine and primary care. Most qualified roles were agenda for change band 8A, although this did vary across specialities. Many roles were restricted to a small number of professions, notably nursing, physiotherapy and paramedic. Inconsistent role titles were noted. A lack of understanding of regulation across different professions was noted.ConclusionThe ACP role has become an accepted across healthcare providers in England. Implementation remains varied across specialities and organizations. Eligibility criteria may relate to professional bias.Implications for the Profession and/or Patient CareACP roles are expanding but this may be at the detriment to advanced nursing posts. Inconsistency in role eligibility suggests some professional bias exists.ImpactThis was scoping of ACP roles across England using job advertisements. ACP roles are common across sectors and specialities but eligibility varies. The research will have impact on those looking to recruit to ACP roles as well as those refining JDs.Reporting MethodNo EQUATOR guideline exists for document analysis.Patient or Public ContributionNo Patient or Public Contribution. The research relates to organizational human resource information only.
Ritual and Affect in Europe Day Celebrations: Institutional Practices of European Identity Construction in Crisis
Authors: Lambert Marina 
Published: March 2023

AbstractThis article analyses Europe Day celebration practices and explores the role of ritual and its utility in eliciting the affective dimension of European identity construction in crisis. The article reflects on the considerable variation of Europe Day celebration practices, proposes a typology of Europe Day events and reflects on their merit in eliciting reason‐ and affect‐driven institutional approaches in the strategic promotion of European identity to the public. The article employs affect theory to reflect on the relationship between emotions and identity. It argues that institutional efforts aimed to promote European identity within the Europe Day platform rely on actualizing the affective potential underpinning collective identities with the view to compel public support for European integration by inciting emotional engagement and boosting the public's affective investment.
Risk prediction of hepatobiliary and pancreatic cancers in elderly Chinese: The Dongfeng‐Tongji cohort
Authors: Lyu Jingjing , Guan Xin , Zhou Yuhan , Guo Huan , Cheng Shanshan , Wang Chaolong 
Published: March 2023

AbstractAimHepatobiliary and pancreatic (HBP) cancers are among the deadliest malignancies. The objective of the study is to build cost‐effective models to identify high‐risk individuals for early diagnosis and substantially to reduce the burden of HBP cancers.MethodsBased on the prospective Dongfeng‐Tongji cohort with ∼6 years follow‐up, we identified 162 incident cases of hepatocellular carcinoma (HCC), 53 of biliary tract cancer (BTC), and 58 of pancreatic cancer (PC). We matched three controls to each case by age, sex, and hospital. We applied conditional logistic regression to identify predictive clinical variables, from which we constructed clinical risk scores (CRSs). We evaluated the utility of CRSs in stratifying high‐risk individuals by 10‐fold cross‐validation.ResultsAmong 50 variables we screened, 6 were independent predictors of HCC, with the top ones being hepatitis (OR = 8.51, 95% CI (3.83, 18.9)), plateletcrit (OR = 0.57, 95% CI (0.42, 0.78)), and alanine aminotransferase (OR = 2.06, 95% CI (1.39, 3.06)). Gallstone (OR = 2.70, 95% CI (1.17, 6.24)) and direct bilirubin (OR = 1.58, 95% CI (1.08, 2.31)) were predictive of BTC, while hyperlipidemia (OR = 2.56, 95% CI (1.12, 5.82)) and fasting blood glucose (OR = 2.00, 95% CI (1.26, 3.15)) were predictive of PC. The CRSs achieved AUCs of 0.784 for HCC, 0.648 for BTC, and 0.666 for PC, respectively. When applying to the full cohort with age and sex included as predictors, the AUCs were increased to 0.818, 0.704, and 0.699, respectively.ConclusionsDisease history and routine clinical variables are predictive of incident HBP cancers in elderly Chinese.
Caregiver burden among parents of children with chronic diseases: A cross‐sectional study
Authors: Shattnawi Khulood Kayed , Al Ali Nahla , Almanasreh Ala'a Aref , Al‐Motlaq Mohammad A. 
Published: March 2023

AbstractAims and ObjectivesThis study aimed to assess the perceived caregiver burden among parents of chronically ill children in Jordan.BackgroundAlthough there are few studies on the accurate prevalence of chronic diseases among Jordanian children, there are a few on the burden of caregiving, which is important because most children with chronic illness rely on their caregivers to perform their daily tasks. In Jordan, little is known about the caregiver burden associated with caring for children with chronic diseases.DesignA cross‐sectional design was reported in line with the STROBE guidelines.MethodsThe Katz Index of Independence was used to determine the children's level of dependence, and the Burden Scale for Family Caregivers was used to measure the caregivers' level of burden.ResultsNearly, 49.3% of caregivers had a very severe burden, 31.2% of children had a severe functional impairment, 19.6% had a moderate impairment, and 49.3% had full functionality. Based on their children's dependency, caregivers' subjective burden varied greatly (p < .001). Fully functional children had a far lower disease burden than severely and moderately disabled children (p < .001). The caregiver burden score differed significantly across chronic disease categories (p < .001). Unemployed caregivers had a far higher subjective burden than working caregivers (p = .009), and single (divorced/widowed) caregivers had higher burdens than married caregivers.ConclusionsVarious factors can increase caregiver burden. Therefore, healthcare providers must plan holistic and family‐centred interventions to reduce the caregiving burden.Relevance to Clinical PracticeThere is a need to establish support programs to help reduce the level of burden among caregivers of children with chronic diseases.
The influence of patient and caregiver depression on patient self‐care and caregiver contribution to self‐care in ostomy: A dyadic analysis
Authors: Iovino Paolo , De Maria Maddalena , Corvese Francesco , Giordano Vittoria , Alvaro Rosaria , Vellone Ercole , Villa Giulia 
Published: March 2023

AbstractAims and ObjectivesTo explore the association between patient and caregiver depression and patient self‐care and caregiver contribution to self‐care in the context of ostomy care.BackgroundSelf‐care is essential for ostomy patients and their caregivers. The ostomy self‐care process can be considered a dyadic phenomenon in which the patient and the caregiver interact together and work as a team. The presence of depressive symptoms may limit the patient's ability to perform self‐care and caregivers' abilities to engage in caregiving tasks. Research into the dyadic influence of depression on self‐care behaviours from the perspective of ostomates and their caregivers is still in its infancy.DesignSecondary analysis of a multicentre, cross‐sectional study. The STROBE checklist was used to report the present study.MethodsPatient–caregiver dyads were recruited from eight ostomy outpatient clinics from February 2017 to May 2018. Depression was assessed with the nine‐item Patient Health Questionnaire in both patients and caregivers. Patient self‐care was evaluated with the Ostomy Self‐Care Index, and caregiver contribution to self‐care was assessed with the Caregiver Contribution to Ostomy Self‐Care Index. Both instruments measure the dimensions of maintenance, monitoring and management. The actor–partner interdependence model was performed for the dyadic analysis.ResultsIn total, 252 patient–caregiver dyads (patients: 69.8% male, mean age 70.05; caregivers: 80.6% female, mean age 58.7) were enrolled. Patient depression was positively associated with caregiver contribution to self‐care maintenance. Caregiver depression was negatively associated with self‐care management.Relevance to Clinical PracticeThese findings add a better understanding of the reciprocal influence of dyadic depression on patient and caregiver contributions to self‐care in ostomy contexts was found. Patient and caregiver depression influence patient self‐care and caregiver contribution to self‐care. Therefore, clinicians should assess and treat depression in both members of the dyad to improve self‐care.
Retracted: The Role of Educational Programs in the Development of Secondary Education (on the Example of Training Mathematics Teacher)
Authors: Nurbaeva Dilara M. , Abylkassymova Alma E. , Nurmukhamedova Zhanara M. , Erzhenbek Bulbul 
Published: March 2023

Abstract
Nurbaeva, D. M., Abylkassymova, A. E., Nurmukhamedova, Z. M., Erzhenbek, B. (2023) “” Mind, Brain, and Education (https://onlinelibrary.wiley.com/doi/10.1111/mbe.12349).The above article, published online on 28 January 2023 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor, Paul Matusz, and Wiley Periodicals LLC. Following publication, investigation by the Editor and the publisher revealed concerns about the validity of the data. The peer review process was found to be compromised and the authors were not able to provide underlying data to support the conclusions. As a result, the findings reported in the article are not considered reliable. The authors did not respond when informed about the decision to retract.