bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interleukin‐37 promotes DMBA/TPA skin cancer through SIGIRR‐mediated inhibition of glycolysis in CD103+DC cells
Authors: Zeng Fan‐lian , Wang Xiao‐yan , Hu Ya‐wen , Wang Zhen , Li Ya , Hu Jing , Yu Jia‐dong , Zhou Pei , Teng Xiu , Zhou Hong , Zheng Hua‐ping , Zhao Fu‐lei , Gu Lin‐na , Yue Cheng‐cheng , Chen Shu‐wen , Cheng Juan , Hao Yan , Zhao Qi‐xiang , Zhang Chen , Zou Song , Hu Zhong‐lan , Wei Xiao‐qiong , Liu Xiao , Li Guo‐lin , Huang Nong‐yu , Wu Wen‐ling , Zhou Yi‐fan , Li Wei , Cui Kaijun , Li Jiong 
Published: March 2023

AbstractInterleukin 37 (IL‐37), a member of the IL‐1 family, is considered a suppressor of innate and adaptive immunity and, hence is a regulator of tumor immunity. However, the specific molecular mechanism and role of IL‐37 in skin cancer remain unclear. Here, we report that IL‐37b‐transgenic mice (IL‐37tg) treated with the carcinogenic 7,12‐dimethylbenzoanthracene (DMBA)/12‐o‐tetradecylphorbol‐13‐acetate (TPA) exhibited enhanced skin cancer and increased tumor burden in the skin by inhibiting the function of CD103+ dendritic cells (DCs). Notably, IL‐37 induced rapid phosphorylation of adenosine 5‘‐monophosphate (AMP)‐activated protein kinase (AMPK), and via single immunoglobulin IL‐1‐related receptor (SIGIRR), inhibited the long‐term Akt activation. Specifically, by affecting the SIGIRR‐AMPK‐Akt signaling axis, which is related to the regulation of glycolysis in CD103+DCs, IL‐37 inhibited their anti‐tumor function. Our results show that a marked correlation between the CD103+DC signature (IRF8, FMS‐like tyrosine kinase 3 ligand, CLEC9A, CLNK, XCR1, BATF3, and ZBTB46) and chemokines C‐X‐C motif chemokine ligand 9, CXCL10, and CD8A in a mouse model with DMBA/TPA‐induced skin cancer. In a word, our results highlight that IL‐37 as an inhibitor of tumor immune surveillance through modulating CD103+DCs and establishing an important link between metabolism and immunity as a therapeutic target for skin cancer.
A new set of KNIME nodes implementing the QPhAR algorithm
Authors: Kohlbacher Stefan M. , Ibis Gökhan , Permann Christian , Bryant Sharon , Langer Thierry , Seidel Thomas 
Published: March 2023

AbstractDissemination of novel research methods, especially in the form of chemoinformatics software, depends heavily on their ease of applicability for non‐expert users with only a little or no programming skills and knowledge in computer science. Visual programming has become widely popular over the last few years, also enabling researchers without in‐depth programming skills to develop tailored data processing pipelines using elements from a repository of predefined standard procedures. In this work, we present the development of a set of nodes for the KNIME platform implementing the QPhAR algorithm. We show how the developed KNIME nodes can be included in a typical workflow for biological activity prediction. Furthermore, we present best‐practice guidelines that should be followed to obtain high‐quality QPhAR models. Finally, we show a typical workflow to train and optimise a QPhAR model in KNIME for a set of given input compounds, applying the discussed best practices.
KomaMRI.jl: An open‐source framework for general MRI simulations with GPU acceleration
Authors: Castillo‐Passi Carlos , Coronado Ronal , Varela‐Mattatall Gabriel , Alberola‐López Carlos , Botnar René , Irarrazaval Pablo 
Published: March 2023

PurposeTo develop an open‐source, high‐performance, easy‐to‐use, extensible, cross‐platform, and general MRI simulation framework (Koma).MethodsKoma was developed using the Julia programming language. Like other MRI simulators, it solves the Bloch equations with CPU and GPU parallelization. The inputs are the scanner parameters, the phantom, and the pulse sequence that is Pulseq‐compatible. The raw data is stored in the ISMRMRD format. For the reconstruction, MRIReco.jl is used. A graphical user interface utilizing web technologies was also designed. Two types of experiments were performed: one to compare the quality of the results and the execution speed, and the second to compare its usability. Finally, the use of Koma in quantitative imaging was demonstrated by simulating Magnetic Resonance Fingerprinting (MRF) acquisitions.ResultsKoma was compared to two well‐known open‐source MRI simulators, JEMRIS and MRiLab. Highly accurate results (with mean absolute differences below 0.1% compared to JEMRIS) and better GPU performance than MRiLab were demonstrated. In an experiment with students, Koma was proved to be easy to use, eight times faster on personal computers than JEMRIS, and 65% of test subjects recommended it. The potential for designing acquisition and reconstruction techniques was also shown through the simulation of MRF acquisitions, with conclusions that agree with the literature.ConclusionsKoma's speed and flexibility have the potential to make simulations more accessible for education and research. Koma is expected to be used for designing and testing novel pulse sequences before implementing them in the scanner with Pulseq files, and for creating synthetic data to train machine learning models.
Laboratory studies of potential competition for food and substrate among early juvenile Missouri River sturgeon and sympatric chub species
Authors: Wildhaber Mark L. , Albers Janice L. 
Published: March 2023

Abstract

Objective
Juvenile Pallid Sturgeon Scaphirhynchus albus predominantly consume midges (family Chironomidae) and other macroinvertebrates, while Shovelnose Sturgeon S. platorynchus, Sicklefin Chub Macrhybopsis meeki, and Shoal Chub M. hyostoma feed on those same macroinvertebrates throughout life. The primary objective of this study was to assess the substrate component of habitat selection, specifically selection between sand and mud substrates, as it relates to food availability and quantity relative to presence or absence of a photoperiod (i.e., lack of light). The study was designed to assess the strength of the innate linkage of substrate and availability of food in foraging by early juvenile Pallid Sturgeon, early juvenile Shovelnose Sturgeon, their juvenile hybrids, and adult Sicklefin Chub and Shoal Chub. The ultimate goal of the study was to develop a better understanding of potential competition for resources among these five fish groups.

Methods:
Twenty-four individually isolated aquaria were used to test behavior during a 12 h light : 12 h dark cycle versus continuous darkness. Presence or absence of a photoperiod was combined with feeding levels of maximum ration (Cmax) versus half Cmax ration and the substrate to which food was delivered.

Result:
Four-way ANOVA among all five groups and separate ANOVAs for sturgeon and chub groups that included fish group as a factor indicated a selection (i.e., proportion of time over substrate &gt;0.5 given only two substrates equally available) for the substrate to which food was delivered, as expected. However, selection of mud was significantly greater for early juvenile Pallid Sturgeon compared with other fish groups except early juvenile Shovelnose Sturgeon. Neither feeding level nor presence or absence of a photoperiod significantly affected substrate selection. In individual fish group three-way ANOVAs, Sicklefin Chub did not select a substrate significantly more when food was delivered to the substrate. Shoal Chub selected mud more frequently under continuous darkness. All three sturgeon groups showed a significant increase in weight over time. Only Shovelnose Sturgeon and Sicklefin Chub final weight were significantly greater under Cmax compared to half Cmax. Additionally, early juvenile Pallid Sturgeon, early juvenile Shovelnose Sturgeon, and hybrid sturgeon groups had a greater increase in weight over the study under Cmax than half Cmax.

Conclusion:
While caution should always be used when extrapolating results from fine-scaled, controlled laboratory studies to large, complex river systems, the results from this study support the hypothesis of the potential for competition in the lower Missouri River among the studied fish groups.
High‐fidelity modeling of the braiding process for generating the realistic mesostructure of preforms in braided composites
Authors: Li Yiding , Yan Shibo , Yan Ying , Zhang Weijie 
Published: March 2023

AbstractAn accurate method for modeling the braided preforms is vital for the mesoscopic performance analysis of tubular composites. This study proposed a high‐fidelity virtual braiding model for the general braiding process, which further considers the fiber‐level deformation of the yarns during the braiding process to generate the realistic mesostructure of preforms in tubular composites. The method uses the digital element approach previously proposed for weaving processes to model the braiding yarn. The whole braiding process, including the deposition zone and convergence zone, is incorporated into the model to account for the effect of interaction in these zones on the preform mesostructure. Two braiding processes were simulated with the proposed virtual braiding method. The simulated geometry of the braided preforms and the yarn paths in the convergence zone agree well with the reported experimental results. To facilitate the performance analysis of braided composite structures, further automated generation of solid cell instances based on the obtained braided preforms was studied. Importantly, this work could reduce the considerable effort required for characterizing the mesostructure via the costly micro‐CT scans for braided composites, and the generated geometry of the braided preform is more precise than the widely used highly idealized models.
Fabrication and characterization of cellulose acetate ultrafiltration membrane and its application for efficient bovine serum albumin separation
Authors: Gao Xiaojie , Du Shiheng , Si Junhui , Liu Xiaolong , Cui Zhixiang , Wang Qianting 
Published: March 2023

AbstractTo solve the easy contamination problem of ultrafiltration membranes during protein separation, a series of cellulose acetate (CA) ultrafiltration membranes with different pore morphology and structure were successfully prepared by combining solution casting, non‐solvent‐induced phase inversion, and pore‐forming agent leached out technologies. The effects of molecule weight and the content of porogen polyethylene glycol (PEG) on the pore morphology, chemical composition, and wettability of the CA ultrafiltration membrane were systematically studied. The feed permeability, bovine serum albumin rejection, and anti‐fouling ability were also investigated. The results showed that the CA10k membrane has the highest pure water flux of 877.5 L/m2h.bar, largest bovine serum albumin (BSA) rejection of 96.5% and flux recovery rate of 90.9% when the PEG molecule weight and content are 10 kDa and 10 wt%. Those results showed that the CA ultrafiltration membranes have great application prospects in the BSA separation area.
Velocity Laws for Bound States in Asymptotically AdS Geometries
Authors: Giataganas Dimitrios 
Published: March 2023

AbstractWe study the behavior of heavy quark bound states in moving plasmas that are dual to theories with generic non‐trivial renormalization group flows interpolating between an AdS geometry in the ultraviolet and infrared fixed points with broken symmetries. We investigate analytically the observables associated with the bound state and find their scaling exponents with respect to the Lorentz factor for ultrarelativistic motion. Despite having asymptotically an AdS geometry, the scaling is not universal and depends on geometric conditions of the Fefferman‐Graham expansion in the near boundary regime, or equivalently on the order of the asymptotic background expansion that provides the leading contributions to the Wilson loops. We finally discuss the qualitative implications on the dissociation of the bound states with respect to the relative angle of motion.
Total steroidal saponins from black nightshade (Solanum nigrum L.) overcome tumor multidrug resistance by inducing autophagy‐mediated cell death in vivo and in vitro
Authors: Wang Yi , Wang Siyu , Xu Jingwen , Wang Yihai , Xiang Limin , He Xiangjiu 
Published: March 2023

AbstractMultiple drug resistance (MDR) often occurs after prolonged chemotherapy, leading to refractory tumors and cancer recurrence. In this study, we demonstrated that the total steroidal saponins from Solanum nigrum L. (SN) had broad‐spectrum cytotoxic activity against various human leukemia cancer cell lines, especially in adriamycin (ADR)‐sensitive and resistant K562 cell lines. Moreover, SN could effectively inhibit the expression of ABC transporter in K562/ADR cells in vivo and in vitro. In vivo, by establishing K562/ADR xenograft tumor model, we demonstrated that SN might overcome drug resistance and inhibit the proliferation of tumors by regulating autophagy. In vitro, the increased LC3 puncta, the expression of LC3‐II and Beclin‐1, and the decreased expression of p62/SQSTM1 in SN‐treated K562/ADR and K562 cells demonstrated autophagy induced by SN. Moreover, using the autophagy inhibitors or transfecting the ATG5 shRNA, we confirmed that autophagy induced by SN was a key factor in overcoming MDR thereby promoting cell death in K562/ADR cells. More importantly, SN‐induced autophagy through the mTOR signaling pathway to overcome drug resistance and ultimately induced autophagy‐mediated cell death in K562/ADR cells. Taken together, our findings suggest that SN has the potential to treat multidrug‐resistant leukemia.
Intrinsic magnetism with high critical temperatures and piezoelectricity in 2D transition metal tetraborides
Authors: Sun Yi , Duan Yuanyuan , Li Xiaoyan , Xu Xiaokang , Yao Xiaojing , Liu Siyuan , Yin Huabing , Wang Bing , Liu Yongjun , Zhang Xiuyun 
Published: March 2023

AbstractDeveloping 2D materials with intrinsic magnetism is an essential issue owing to their wide potential applications in spintronics. Here, a type of transition metal tetraborides, TMB4, (TM = TiCo) monolayers were systematically investigated by employing first principles calculations. Our results showed that the predicted structures hold buckled motif, ultrahigh stability and large magnetic anisotropy energy. It is revealed that CrB4, MnB4, and FeB4 monolayers are robust ferromagnetism, differently, TiB4, VB4, and CoB4 monolayers are stable anti‐ferromagnetism. Based on the Monte Carlo simulation, the critical temperatures of these magnetic systems are around 177–755 K. Most importantly, CoB4 monolayer is confirmed to be an antiferromagnetic semiconductor with out‐of‐plane magnetic easy axis and out‐of‐plane piezoelectricity with large piezoelectric stress coefficients. Our study suggests that the 2D TMB4s hold promising applications for spintronic devices and piezoelectric devices.
Thermochromic Ni(II) Organometallics With High Optical Transparency and Low Phase‐Transition Temperature for Energy‐Saving Smart Windows
Authors: Yu Danxia , Zhuo Sheng , Wang Jia , Liu Zheng , Ye Jianyong , Wang Yue , Chen Long , Ouyang Xingxing , Zhang Ke‐Qin , Zhou Xiao‐Qing , Guan Jinping , Liu Yue , Chen Weifan , Liao Liang‐Sheng , Zhuo Ming‐Peng 
Published: March 2023

AbstractThermochromic smart windows with rational modulation in indoor temperature and brightness draw considerable interest in reducing building energy consumption, which remains a huge challenge to meet the comfortable responsive temperature and the wide transmittance modulation range from visible to near‐infrared (NIR) light for their practical application. Herein, a novel thermochromic Ni(II) organometallic of [(C2H5)2NH2]2NiCl4for smart windows is rationally designed and synthesized via an inexpensive mechanochemistry method, which processes a low phase‐transition temperature of 46.3 °C for the reversible color evolution from transparent to blue with a tunable visible transmittance from 90.5% to 72.1%. Furthermore, cesium tungsten bronze (CWO) and antimony tin oxide (ATO) with excellent NIR absorption in 750–1500 and 1500–2600 nm are introduced in the [(C2H5)2NH2]2NiCl4‐based smart windows, realizing a broadband sunlight modulation of a 27% visible light modulation and more than 90% of NIR shielding ability. Impressively, these smart windows demonstrate stable and reversible thermochromic cycles at room temperature. Compared with the conventional windows in the field tests, these smart windows can significantly reduce the indoor temperature by 16.1 °C, which is promising for next‐generation energy‐saving buildings.
Analysis on displacement‐based seismic design method of recycled aggregate concrete‐filled square steel tube frame structures
Authors: Zhang Xianggang , Liu Xuyan , Zhang Songpeng , Wang Junbo , Fu Lei , Yang Junna , Huang Yajun 
Published: March 2023

AbstractRecycled aggregate concrete‐filled square steel tube (S‐RACFST) frame has the characteristics of high bearing capacity, good ductility, and superior seismic performance. To propose a displacement‐based seismic design of S‐RACFST frame, the validity of the design method was verified by a detailed calculation example. Based on the performance requirements, this design method divided the structural performance into five levels: normal use, temporary use, use after strengthening, life safety, and collapse prevention, and suggested specific steps for the displacement‐based seismic design of S‐RACFST frame using the inter‐story displacement angle limit value as the quantitative indicator. The 10‐story S‐RACFST frame was used as an analytical example for static elastic–plastic analysis. The pushover lateral displacement curves of the frame structure at each performance level were obtained and compared with the displacement‐based seismic design curves. The results show that the displacement‐based seismic design method of S‐RACFST frame structures can fulfill the performance level requirements such as “temporary use,” “normal use,” and “collapse prevention,” and the displacement‐based seismic design method is one of the effective ways to realize the performance design of S‐RACFST frame structures.
Has the therapeutical ceiling been reached in Crohn's disease randomized controlled trials? A systematic review and meta‐analysis
Authors: Magro Fernando , Moreira Paula Leão , Catalano Gaia , Alves Catarina , Roseira Joana , Estevinho Maria Manuela , Silva Isabel , Dignass Axel , Peyrin‐Biroulet Laurent , Danese Silvio , Jairath Vipul , Dias Claudia Camila , Santiago Mafalda 
Published: March 2023

AbstractBackground and AimsThe availability of biological agents for inflammatory bowel disease has increased over the past years. In this systematic review and meta‐analysis, we aimed to explore time trends in clinical response and clinical remission rates in Crohn's disease (CD) patients treated with biologics while discussing the need for new strategies.MethodsMEDLINE, Cochrane, and ISI Web of Science databases were searched for randomized placebo‐controlled trials with biological agents in moderate‐to‐severe CD patients. Sub‐group and meta‐regression analyses compared treatment and placebo by calculating the pooled odds ratios of clinical remission and clinical response, across time categories and publication year. We also estimated the proportion of patients achieving clinical remission and clinical response by comparing both groups according to the publication year.ResultsTwenty‐five trials were included in the systematic review, which enrolled 8879 patients between 1997 and 2022. The clinical remission and clinical response odds, in induction and maintenance, have been constant over time, as no statistically significant differences were found between time categories (interaction p‐values: clinical remission [induction, p = 0.19; maintenance, p = 0.24]; clinical response [induction, p = 0.43; maintenance, p = 0.59]). In meta‐regression analyses, publication year did not influence these outcomes (clinical remission [induction, OR 1.01{95% CI 0.97–1.05}, p = 0.72; clinical response [induction, OR 1.01{95% CI 0.97–1.04]; p = 0.63; maintenance, OR 1.03{95% CI 0.98–1.07}; p = 0.21]), with the exception of clinical remission in maintenance studies, which presented a decreased effect (odds ratio 0.97{95% CI 0.94–1.00}, p = 0.03]).ConclusionsOur review highlights that the odds of clinical outcomes in CD patients receiving biological treatment relative to placebo have been stable in the last decades.
Polare Substanzen in der Ruhr
Authors: Härtel Christoph 
Published: March 2023

ZusammenfassungDurch die Neu‐ und Weiterentwicklung von analytischen Methoden können heutzutage neben unpolaren und polaren auch sehr polare und mobile Substanzen untersucht werden. Aufgrund möglicher Trinkwasserrelevanz sowie Diskussionen in Fachkreisen erweitert der Ruhrverband sein Routineuntersuchungsprogramm seit einigen Jahren kontinuierlich auch um Vertreter aus dieser Gruppe. Die Proben der Ruhr werden derzeit neben einem der bekanntesten polaren Spurenstoffe Glyphosat auf weitere potenziell kritische polare Substanzen wie Trifluoressigsäure und Amidosulfonsäure untersucht. Für alle geprüften Substanzen gilt, dass verglichen mit anderen Oberflächengewässern in Nordrhein‐Westfalen und Deutschland keine Auffälligkeiten zu erkennen sind und bestehende gesetzliche Anforderungen sicher eingehalten werden.
Learning and community building in support of collective action: Toward a new climate of communication at the COP
Authors: Mar Kathleen A. , Schäpke Niko , Fraude Carolin , Bruhn Thomas , Wamsler Christine , Stasiak Dorota , Schroeder Heike , Lawrence Mark G. 
Published: March 2023

AbstractThe international UN Climate Change conferences known as “Conferences of the Parties (COPs)” have an enormous convening power and are attended annually by tens of thousands of actors working on climate change topics from a wide range of perspectives. In the COP spaces outside of the formal negotiations, the communication culture is dominated by “side events,” a format that relies heavily on conventional presentations and panels that can be informative, but is generally not conducive to mutual engagement, reflection, or dialogue. There is an urgent need for new dialogue formats that can better foster learning and community‐building and thereby harness the enormous latent potential for climate action represented by the diverse stakeholders that gather at the COP. Against this backdrop, and drawing on our experience with the development and implementation of the Co‐Creative Reflection and Dialogue Spaces at COP25, COP26, and COP27, we make recommendations for further developing the communication culture of the COPs. At the level of individual sessions, we provide recommendations for designing participatory dialogues that can better support reflection, interconnection, and action orientation. In addition, we offer guidance for scaling up these practices, for instance through networks and communities of practice to support a shift of the overall communication culture of the COPs. Our recommendations focus on interactions and exchanges that unfold outside of the formal negotiation sessions, with a view toward enabling and accelerating transformative action by non‐state actors.This article is categorized under:
Perceptions, Behavior, and Communication of Climate Change > Communication
Policy and Governance > International Policy Framework