bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Oferta Turística de Percursos Pedestres em Trás-OsMontes e Alto Douro (TMAD): Mecanismos de Desenvolvimento Regional?
Authors: Azevedo Pedro , Pereiro Xerardo 
Published: March 2023

Caminhar é uma das atividades humanas mais democráticas e que não precisa de grande equipamento nem investimento. Caminhar é uma necessidade, ancorada no bipedismo humano, passou a ser hoje uma atividade humana de prazer, de ostentação de classe e de estatuto social. Nas últimas décadas tem aumentado profundamente a oferta e a procura de percursos pedestres para locais e visitantes, que caminham por múltiplos motivos, desde desportivos até culturais, turísticos, religiosos e espirituais.
Nos últimos anos, as autarquias da região de Trás-os-Montes e Alto Douro (TMAD) têm apostado na implementação de percursos pedestres nos seus territórios que assentam em dois eixos centrais: permitem a dinamização turística do território bem como constituem um mecanismo de desenvolvimento a nível local e regional através da criação, interpretação e ressignificação de caminhos tradicionais como roteiros pedestres. É esta a vocação territorial de TMAD? No nosso texto queremos avaliar essa vocação.
Perante os escassos estudos sobre os roteiros e itinerários pedestres existentes nesta região, este artigo tem por objetivo a apresentação de um inventário dos percursos pedestres existentes em Trásos-Montes e Alto Douro, através da sua identificação bem como da sua caraterização. Para além disso, pretendemos interpretar os significados e sentidos da criação e expansão destes percursos pedestres e esboçar alguns dos seus usos e funções.
Através da aplicação de uma metodologia documental e de investigação de terreno, identificamos os percursos pedestres divulgados nos sites das autarquias, pretendemos assim compreender a sua evolução e fazer uma análise interpretativa destes percursos e dos guias turísticos associados.
Os resultados obtidos demonstram que existe um total de 156 percursos pedestres em TMAD, divididos em Pequena Rota (PR) e Grande Rota (GR), indo ao encontro de discursos e valores contemporâneos ligados ao ambiente, à ecologia e à sustentabilidade.
« Aheumplace » : marges et marginalités dans Les héritiers de la mine de Jocelyne Saucier
Authors: Beaudoin Karine 
Published: March 2023

Cet article porte sur les représentations de la marginalité dans Les héritiers de la mine, un roman de la Québécoise Jocelyne Saucier (2000). Parce qu’il multiplie dès l’incipit les figures de décentrement, l’imaginaire déployé apparaît d’abord comme le lieu d’une négociation où la non-conformité est reine. Cependant, au fil de la lecture, une « poétique de l’entre-deux », portée par le personnage d’Angèle, finit par casser la classique dichotomie nous/eux découlant d’une marge réduite à son unique logique d’exclusion. Il s’agira donc d’exposer le tissage sémiotique d’une identité-frontière, en constant équilibre sur le « mince fil » d’un idéal vécu « sans compromission ».
Récit d’héritage, de transmission et de passation : l’expérience corporelle et la construction identitaire dans Le corps des bêtes
Authors: Drouin Émilie 
Published: March 2023

Éprouvant un malaise par rapport à son propre corps, qu’elle ne connaît pas, Mie emprunte le « corps des bêtes » et y glisse son esprit afin d’apprivoiser la sexualité. Dans le roman d’Audrée Wilhelmy, l’animalité est racontée comme une façon de faire l’expérience d’un corps autre (grue, loutre, ours) dans une quête identitaire qui sert finalement à la médiation entre l’enfance – passée et actuelle – et la féminité – espérée et à venir –, et qui aboutit à un récit de passation lorsque Noé, la mère de Mie, lui cède sa place.
Comparative ultrastructure of the antennae and sensory hairs in six species of crayfish
Authors: Kor Golara , Mengal Kifayatullah , Buřič Miloš , Kozák Pavel , Niksirat Hamid 
Published: March 2023

Background
Antennae in crayfish are essential for gaining information about the local topography and localising food, chemicals, conspecifics or predator. There are still gaps in the research on the morphology of antennae in decapods compared to other arthropods.

Methodology
Biometrical and ultrastructural methods were applied using light and cryo-scanning electron microscopies to study the morphology of antennae in six different crayfish species, including marbled crayfish Procambarus virginalis, Mexican dwarf crayfish Cambarellus patzcuarensis, red swamp crayfish Procambarus clarkii, signal crayfish Pacifastacus leniusculus, common yabby Cherax destructor, and spiny-cheek crayfish Faxonius limosus to find their potential morphological differences.

Results
Significant differences in the antenna length, length and width of each segment to carapace length ratios, and the number of segments were found in the six crayfish species. The ultrastructure revealed differences in the distribution of sensory hairs on the antenna and the morphology of the antennal surface.

Conclusions
The different morphology of antennae might reflect adaptation to the conditions of their specific habitats. In addition, results showed that a combination of differences in the morphological features and biometrical measurements of antennae could be used for the distinguishment of different studied crayfish species.
Guselkumab, a Selective Interleukin‐23 p19 Subunit Inhibitor, Resolves Dactylitis in Patients With Active Psoriatic Arthritis: Pooled Results Through Week 52 From Two Phase 3 Studies
Authors: McGonagle Dennis , McInnes Iain B. , Deodhar Atul , Schett Georg , Shawi May , Chakravarty Soumya D. , Kollmeier Alexa P. , Xu Xie L. , Sheng Shihong , Xu Stephen , Ritchlin Christopher T. , Rahman Proton , Mease Phillip J. 
Published: March 2023

ObjectivePrevious analyses of pooled DISCOVER‐1 and DISCOVER‐2 data through Week 24 showed significantly higher rates of dactylitis resolution in patients treated with guselkumab compared with placebo. Here, we investigate associations between dactylitis resolution and other outcomes through 1 year.MethodsPatients were randomized 1:1:1 to receive subcutaneous injections of guselkumab 100 mg at Week 0, Week 4, and then every 4 or 8 weeks, or placebo with crossover to guselkumab at Week 24. Independent assessors determined dactylitis severity score (DSS; 0‐3/digit; total = 0‐60). Dactylitis resolution (DSS = 0) (prespecified) and at least 20%, at least 50%, and at least 70% DSS improvement from baseline (post hoc) were determined through Week 52 (nonresponder imputation for treatment failure through Week 24 and for missing data through Week 52). ACR50, tender/swollen joints, low disease activity (LDA) as assessed by composite indices, and radiographic progression (DISCOVER‐2 only) were assessed in patients with dactylitis versus without dactylitis resolution at Week 24 and Week 52.ResultsPatients with dactylitis at baseline (473 of 1118) had more severe joint and skin disease than those without dactylitis (645 of 1118). At Week 52, approximately 75% of guselkumab‐randomized patients with dactylitis at baseline had complete resolution; approximately 80% had at least 70% DSS improvement. Through Week 52, new‐onset dactylitis (DSS ≥1) was uncommon among patients with a DSS of 0 at baseline. Guselkumab‐randomized patients with dactylitis resolution were more likely to achieve ACR50, at least 50% reduction in tender and swollen joints, and LDA at Week 24 and Week 52 than those without resolution. At Week 52, patients with dactylitis resolution had numerically less radiographic progression from baseline (DISCOVER‐2).ConclusionThrough 1 year, approximately 75% of guselkumab‐randomized patients had complete resolution of dactylitis; patients exhibiting resolution were more likely to achieve other important clinical outcomes. Given the high burden of dactylitis, resolution may be associated with better long‐term patient outcomes.
Self‐Healing Photochromic Elastomer Composites for Wearable UV‐Sensors
Authors: Yimyai Tiwa , Crespy Daniel , Pena‐Francesch Abdon 
Published: March 2023

AbstractPhotochromic materials have recently received strong interest for the development of wearable ultraviolet (UV) detection technologies because they do not require electronic components, resulting in systems and devices that change color upon irradiation. However, their implementation in wearable technology has lightweight, compliance, and durability (especially under mechanical stress) requirements that are limited by the materials’ properties. Here, a self‐healing photochromic elastomer composite (photoPUSH) consisting of phosphomolybdic acid (PMA) in a self‐healing polyurethane dynamic network with reversible disulfide bonds (PUSH) is presented. The unique properties of the dynamic polymer matrix enable multiple complementary functions in the UV‐sensing composite: i) photochromism via electron donor groups without requiring additional dopants, ii) stretchability and durability via elastomeric properties, iii) healing of extreme mechanical damage via dynamic bonds, and iv) multimaterial integration via adhesive properties. PhotoPUSH composites exhibit excellent durability, tunable sensing range, and no loss of performance under mechanical stress and severe damage, as well as in underwater environments (waterproof). Leveraging these properties, soft, portable, multimaterial photoPUSH‐based UV‐sensing devices are developed for applications in environmental monitoring, packaging, and healthcare wearable technology (including skin‐mounted, textile‐mounted, and wristband devices) in challenging environments and tunable to different skin types.
Photocrosslinkable, Injectable Locust Bean Gum Hydrogel Induces Chondrogenic Differentiation of Stem Cells for Cartilage Regeneration
Authors: Qu Yangyang , He Si , Luo Shixing , Zhao Jinmin , Liang Ruiming , Liao Chuanan , Zheng Li 
Published: March 2023

AbstractDue to the limited therapeutic efficacy of current treatments, articular cartilage regeneration is still challenging work. Scaffold‐based tissue engineering provides a promising strategy for cartilage regeneration, but most scaffolds are limited by poor mechanical properties or unfavorable biocompatibility. Here, a novel photocrosslinkable, injectable locust bean gum (LBG)–methacrylate (MA) hydrogel is reported as a biomimetic extracellular matrix (ECM) for cartilage repair with minimal invasive operation. LBG‐MA hydrogels show controllable degradation rate and improve mechanical properties and excellent biocompatibility. More importantly, LBG‐MA hydrogel significantly induces bone mesenchymal stem cells to chondrogenic differentiation in vitro, as evidenced by high accumulation of cartilage‐specific ECM components glycosaminoglycan and upregulated expression of key chondrogenic genes (collagen type II, aggrecan, and sex determining region Y‐box9). Besides, the hydrogel is injectable, which can be in situ crosslinked via UV irradiation. Further, the photocrosslinkable hydrogels accelerate cartilage healing in vivo after 8 weeks of therapy. A strategy is provided here for photocrosslinkable, injectable, biodegradable scaffold fabrication based on native polysaccharide polymer for minimal invasive cartilage repair.
Functional traits and trait coordination change over the life of a leaf in a tropical fern species
Authors: Krieg Christopher P. , Seeger Kate , Campany Courtney , Watkins James E. , McClearn Deedra , McCulloh Katherine A. , Sessa Emily B. 
Published: March 2023

AbstractPremisePlant ecological strategies are often defined by the integration of underlying traits related to resource acquisition, allocation, and growth. Correlations between key traits across diverse plants suggest that variation in plant ecological strategies is largely driven by a fast–slow continuum of plant economics. However, trait correlations may not be constant through the life of a leaf, and it is still poorly understood how trait function varies over time in long‐lived leaves.MethodsHere, we compared trait correlations related to resource acquisition and allocation across three different mature frond age cohorts in a tropical fern species, Saccoloma inaequale.ResultsFronds exhibited high initial investments of nitrogen and carbon, but with declining return in photosynthetic capacity after the first year. In the youngest fronds, we found water‐use efficiency to be significantly lower than in the oldest mature fronds due to increased transpiration rates. Our data suggest that middle‐aged fronds are more efficient relative to younger, less water‐use efficient fronds and that older fronds exhibit greater nitrogen investments without higher photosynthetic return. In addition, several trait correlations expected under the leaf economics spectrum (LES) do not hold within this species, and some trait correlations only appear in fronds of a specific developmental age.ConclusionsThese findings contextualize the relationship between traits and leaf developmental age with those predicted to underlie plant ecological strategy and the LES and are among the first pieces of evidence for when relative physiological trait efficiency is maximized in a tropical fern species.
A case of severe paraquat poisoning treated by continuous hemodiafiltration without sequelae
Authors: Hisamura Masaki , Ogura Tomoyuki , Tokuda Mitsuhiro , Nakamura Motohiro , Kenichiro Sonoda , Ando Yoji , Nakata Kazuyuki , Taguchi Hirokazu 
Published: March 2023

BackgroundIn a suicide attempt, a 49‐year‐old male ingested pesticides. He arrived at the hospital restless and vomiting blue liquid.Case PresentationThe patient was diagnosed with paraquat poisoning at a lethal dose and experienced renal dysfunction during treatment. He underwent continuous hemodiafiltration (CHDF). Hemodialysis was temporarily initiated and found to improve renal function. He was discharged on day 36 in good condition. He remains well with only mild renal impairment and no pulmonary fibrosis, 240 days after the incident. The fatality rate of paraquat poisoning is approximately 80%, regardless of the treatment. Early hemodialysis combined with CHDF within 4 h has been reported to be effective. In this case, CHDF was initiated approximately 3 h after paraquat administration and showed a successful outcome.ConclusionCHDF should be performed as soon as possible to treat paraquat poisoning.
Development of a Versatile Protein Labeling Tool for Live‐Cell Imaging Using Fluorescent β‐Lactamase Inhibitors
Authors: Minoshima Masafumi , Umeno Taro , Kadooka Kohei , Roux Margaux , Yamada Namiko , Kikuchi Kazuya 
Published: March 2023

AbstractTo understand the function of protein in live cells, real‐time monitoring of protein dynamics and sensing of their surrounding environment are important methods. Fluorescent labeling tools are thus needed that possess fast labeling kinetics, high efficiency, and long‐term stability. We developed a versatile chemical protein‐labeling tool based on fluorophore‐conjugated diazabicyclooctane β‐lactamase inhibitors (BLIs) and wild‐type TEM‐1 β‐lactamase protein tag. The fluorescent probes efficiently formed a stable carbamoylated complex with β‐lactamase, and the labeled proteins were visualized over a long period of time in live cells. Moreover, use of an α‐fluorinated carboxylate ester‐based BLI prodrug enabled the probe to permeate cell membranes and stably label intracellular proteins after unexpected spontaneous ester hydrolysis. Lastly, combining the labeling tool with a pH‐activatable fluorescent probe allowed visual monitoring of lysosomal protein translocation during autophagy.
Beladung von RNA mit Aminosäuren in einer putativen RNA‐Peptid‐Welt
Authors: Singer Johannes N. , Müller Felix M. , Węgrzyn Ewa , Hölzl Christina , Hurmiz Hans , Liu Chuyi , Escobar Luis , Carell Thomas 
Published: March 2023

AbstractDie RNA ist ein Molekül, das sowohl genetische Informationen speichern als auch katalytische Reaktionen ausführen kann. Dieser beobachtete Dualismus rückt die RNA ins Rampenlicht der Konzepte über den Ursprung des Lebens. Die RNA‐Welt‐Hypothese geht davon aus, dass das Leben aus selbst replizierenden RNA‐Molekülen entstand, die sich zu immer komplexeren Strukturen entwickelten. Vor kurzem haben wir gezeigt, dass RNA mit Hilfe erhaltener nicht‐kanonischer Nukleoside, die potenzielle Relikte einer frühen RNA‐Welt sind, in der Lage ist, Peptide zu bilden, die kovalent an Nukleobasen der RNA gebunden sind, wodurch RNA‐Peptid‐Chimären entstehen. Es ist denkbar, dass solche Moleküle, welche die informationskodierenden Eigenschaften der RNA mit dem katalytischen Potenzial von Aminosäureseitenketten kombinieren können, einst die Strukturen waren, aus denen das Leben entstand. In diesem Artikel berichten wir über präbiotische Chemie, die es ermöglicht sowohl Nukleoside als auch RNA mit Aminosäuren zu beladen, was einen ersten Schritt zu einer RNA‐basierten Peptidsynthese in einer mutmaßlichen RNA‐Peptid‐Welt darstellt.
10–30‐day moist static energy evolutions related to the persistent heavy rainfall event in different stages of flood season over South China
Authors: Zheng Bin , Lin Ailan , Huang Yanyan 
Published: March 2023

AbstractIn this study, the flood season in South China (SC) was divided into three stages: two first rainy seasons (FRSs) around the South China Sea summer monsoon onset and one second rainy season when Typhoon prevails, denoted as FRS1, FRS2, and SRS, respectively, and then we diagnosed the moist static energy (MSE) budget associated with the 10–30‐day persistent heavy rainfall (PHR) over SC during these periods. The results indicate that there are great differences in the recharge of PHR‐related MSE in different stages of the flood season in SC: The FRS1 MSE associated with PHR moves southeastward from midlatitude; the large MSE is maintained in SC during the FRS2; during the SRS, the MSE perturbation propagates from the tropical western North Pacific to SC. From the perspective of the local MSE budget in SC, meridional and zonal advection play a key role in the maximum MSE change in the FRS1; the FRS2 and SRS MSE tendency is mainly determined by zonal advection and meridional advection, respectively. In contrast, the 10–30‐day propagating perturbation of MSE changes during both the FRS1 and FRS2 are mainly affected by the zonal advection, while the meridional circulation is dominant in the SRS. The cumulative contribution of external forcing (including radiation and surface heat fluxes) during the SRS to the propagation of PHR‐related MSE perturbation can reach more than 30%, and the closer to the land, the stronger the external forcing. During the FRS (including FRS1 and FRS2), however, the external forcing contributes little, even negatively.
Hidden population size estimation and diagnostics using two respondent‐driven samples with applications in Armenia
Authors: Kim Brian J. , Johnston Lisa G. , Grigoryan Trdat , Papoyan Arshak , Grigoryan Samvel , McLaughlin Katherine R. 
Published: March 2023

AbstractEstimating the size of hidden populations is essential to understand the magnitude of social and healthcare needs, risk behaviors, and disease burden. However, due to the hidden nature of these populations, they are difficult to survey, and there are no gold standard size estimation methods. Many different methods and variations exist, and diagnostic tools are needed to help researchers assess method‐specific assumptions as well as compare between methods. Further, because many necessary mathematical assumptions are unrealistic for real survey implementation, assessment of how robust methods are to deviations from the stated assumptions is essential. We describe diagnostics and assess the performance of a new population size estimation method, capture–recapture with successive sampling population size estimation (CR‐SS‐PSE), which we apply to data from 3 years of studies from three cities and three hidden populations in Armenia. CR‐SS‐PSE relies on data from two sequential respondent‐driven sampling surveys and extends the successive sampling population size estimation (SS‐PSE) framework by using the number of individuals in the overlap between the two surveys and a model for the successive sampling process to estimate population size. We demonstrate that CR‐SS‐PSE is more robust to violations of successive sampling assumptions than SS‐PSE. Further, we compare the CR‐SS‐PSE estimates to population size estimations using other common methods, including unique object and service multipliers, wisdom of the crowd, and two‐source capture–recapture to illustrate volatility across estimation methods.
Synthesis and characterization of phenothiazine sensor for spectrophotometric and fluorescence detection of cyanide
Authors: Al‐Zahrani Fatimah A. M. , Al‐Ghamdi Huda A. , Abdel‐Lateef Mohamed A. , El‐Shishtawy Reda M. 
Published: March 2023

AbstractA sensitive and selective phenothiazine‐based sensor (PTZ) has been successfully synthesized. The sensor PTZ displayed specific identification of CN− ‘turn‐off’ fluorescence responses with a quick reaction and strong reversibility in an acetonitrile:water (90:10, V/V) solution. The sensor PTZ for detecting CN− exhibits the marked advantages of quenching the fluorescence intensity, fast response time (60 s), and low value of the detection limit. The concentration that is authorized for drinking water by the WHO (1.9 μM) is far higher than the detection limit, which was found to be 9.11 × 10−9. The sensor displays distinct colorimetric and spectrofluorometric detection for CN− anion due to the addition of CN− anion to the electron‐deficient vinyl group of PTZ, which reduces intramolecular charge transfer efficiencies. The 1:2 binding mechanism of PTZ with CN− was validated by fluorescence titration, Job's plot, HRMS, 1H NMR, FTIR analysis, and density functional theory (DFT) investigations, among other methods. Additionally, the PTZ sensor was successfully used to precisely and accurately detect cyanide anions in actual water samples.
Socially responsible investments: A retrospective review and future research agenda
Authors: Beloskar Ved Dilip , Haldar Arunima , Rao S. V. D. Nageswara 
Published: March 2023

AbstractSocially responsible investments (SRIs) have occupied the center stage of discussion in the finance and social discourses. This study aims to unravel the intellectual structure of the research on SRI. At present, SRI is undertheorized, and the extant literature is divided into multiple fragments. Existing review studies on SRI suffer from limitations related to definitions and methods. We organize the theoretical lines of extant research and tie them up with empirical studies in the field by using systematic literature review and bibliometric techniques on a corpus of as large as 976 research articles. Our study describes the current dynamics of the SRI field, clusters the fragments of research into meaningful themes, highlights the impediments to current research, and also proposes an agenda for future research. Although research on SRI occurs globally, the lack of academic collaboration among scholars and undertheorization are two major challenges of the field. Future research could examine ESG‐based asset pricing models, sustainable factor investing, and measures to tackle greenwashing.