bluuebunny/crossref_metadata_2025_split huggingface dataset:
Corrected QT Interval (QTc) Diagnostic App for the Oncological Routine: Development Study
Authors: Klier Kristina , Patel Yash J , Schinköthe Timo , Harbeck Nadia , Schmidt Annette 
Published: September 2023

Background
Numerous antineoplastic drugs such as chemotherapeutics have cardiotoxic side effects and can lead to long QT syndrome (LQTS). When diagnosed and treated in time, the potentially fatal outcomes of LQTS can be prevented. Therefore, regular electrocardiogram (ECG) assessments are critical to ensure patient safety. However, these assessments are associated with patient discomfort and require timely support of the attending oncologist by a cardiologist.

Objective
This study aimed to examine whether this approach can be made more efficient and comfortable by a smartphone app (QTc Tracker), supporting single-lead ECG records on site and transferring to a tele-cardiologist for an immediate diagnosis.

Methods
To evaluate the QTc Tracker, it was implemented in 54 cancer centers in Germany. In total, 266 corrected QT interval (QTc) diagnoses of 122 patients were recorded. Moreover, a questionnaire on routine ECG workflow, turnaround time, and satisfaction (1=best, 6=worst) was answered by the centers before and after the implementation of the QTc Tracker.

Results
Compared to the routine ECG workflow, the QTc Tracker enabled a substantial turnaround time reduction of 98% (mean 2.67, 95% CI 1.72-2.67 h) and even further time efficiency in combination with a cardiologic on-call service (mean 12.10, 95% CI 5.67-18.67 min). Additionally, nurses and patients reported higher satisfaction when using the QTc Tracker. In particular, patients’ satisfaction sharply improved from 2.59 (95% CI 2.41-2.88) for the routine ECG workflow to 1.25 (95% CI 0.99-1.51) for the QTc Tracker workflow.

Conclusions
These results reveal a significant improvement regarding reduced turnaround time and increased user satisfaction. Best patient care might be guaranteed as the exposure of patients with an uncontrolled risk of QTc prolongations can be avoided by using the fast and easy QTc Tracker. In particular, as regular side-effect monitoring, the QTc Tracker app promises more convenience for patients and their physicians. Finally, future studies are needed to empirically test the usability and validity of such mobile ECG assessment methods.

Trial Registration
ClinicalTrials.gov NCT04055493; https://classic.clinicaltrials.gov/ct2/show/NCT04055493
Pathomorphological changes in the lungs in severe COVID-19
Authors: Yakovenko O.K. , Griff S.L. , Hoffmann S. , Khanin О.H. , Khodosh E.M. , Dziublyk Ya.О. 
Published: September 2023

Background. The study of pathogenesis and the search for factors that lead to mortality from severe COVID-19 and disability due to post-COVID interstitial lung disease with permanent physiological and functional deficits is an urgent and unsolved problem today. The purpose was to investigate lung histopathology in patients who died of severe COVID-19 in the acute and post-acute period of the disease, and to determine the significance of histological changes in the lung parenchyma depending on gender, duration of the disease, and the use or non-use of respiratory support. Materials and methods. The study included the results of lung sample analysis in patients with severe COVID-19 who died from June to December 2020 (n = 10) and from January to December 2021 (n = 21). An autopsy was performed in 61.3 % of patients who died in the acute period of the disease (up to the 28th day), and in 38.7 % of those who died in the post-acute period (day 29–84). Respiratory support was used in 58 % (n = 18) of cases in the acute period. Results. Patients with severe COVID-19 who did not survive the acute period of the disease (its average duration was 17.31 days, the average age of the deceased was 66.1 years) and the post-acute period (the average duration of the disease was 43.22 days, the average age of the deceased was 67.8 years) had the following: the presence of hyaline membranes in 70.9 %, capillary stasis in 77.4 %, organizing pneumonia in 41.9 %, pulmonary fibrosis in 32.2 %, hemorrhages in 38.7 %, small vein thrombosis in 25.8 %, histospecific signs of bacterial and fungal co-infection in 16.1 and 3.2 %, respectively, diffuse alveolar damage in 90.3 % of cases (with acute fibrinous and organizing pneumonia in 9.6 %). Conclusions. The risk of capillary stasis is significantly higher in the post-acute than in the acute period of the disease (p = 1.7454). No statistically significant correlation was found between the acute (p = 0.359) and post-acute (p = 0.146) periods and the risk of pulmonary fibrosis. Also, no significant relationship was detected between the use of respiratory support and recorded pulmonary fibrosis in the acute (p = 0.238) and post-acute (p = 0.302) periods. It was found that the histopathological signs of hemorrhages in the lungs are the same in both periods compared to the small vein thrombosis whose risk in the acute period is significantly higher than in the post-acute one (p = 0.05). The risk of bacterial co-infection in the acute period of the disease is significantly lower than the probability of its absence (p = 0.001). The risk of a fatal outcome in the acute period of the disease among men is significantly higher than among women (p = 0.05), while in the post-acute period, there is no statistically significant dependence on gender.
The Elderly Knowledge Improvement of Balanced Nutrition in Patangpuluhan, Yogyakarta
Authors: Widyaningrum Rachmawati 
Published: September 2023

Background Elderly is a vulnerable group to body function impairment and diseases. Although these conditions are considered a normal result of the aging process, the elderly's health level should be maintained. The application of balanced diet principles is one of the ways to reduce the risk and improves the health quality of the elderly. In this regard, the education program about balanced diet principles to enhance the group's knowledge is essential to support a healthier lifestyle for the elderly.Objective. This education program aimed to improve the elderly group's knowledge in this area of balanced nutrition to maintain the elderly health state. Results. There were 30 participants, with majority of the participants was women (90%). The results of pre and post-test show that there was 17 points increment in participants' knowledge (21%) compared to the pre-test score. Question topics that got the two highest score improvements were the duration of psychical activity and the purine-contains food groups (21,7 points). Conclusion This education program could raise elderly knowledge of balanced nutrition and this kind of program is recommended to be applied on a regular basis based on the elderly need for health and nutrition-related information. The male elderly also has to be encouraged to actively involves in the community-based education to improve their knowledge of elderly health.
The Extraction of Curcuminoids From Ethanol Extract of Yellow Turmeric (Curcuma longa L) and Activity Test on P-388 Murine Leukemia Cells
Authors: Wati Ida , Dwi Partiwi Vibianti , Ramdianti Musadi Maya 
Published: September 2023

Abstract: Research on the Extraction of Curcuminoids from Ethanol Extract of Yellow Turmeric (Curcuma longa L) and its Activity Test on P-388 Murine Leukemia Cells has been carried out. This study aims to determine the per cent yield, solvent concentration, activity of P-388 murine leukemia cells and pH of the number of curcuminoids produced in ethanol extract. The curcuminoids were obtained by the extraction process through the soxhlet method using 70 and 96% ethanol solvent with a ratio of sample to solvent of 1:8 with variations in operating time for 3, 6, 9 and 12 hours. The absorbance of curcuminoid extract was measured to determine the concentration of curcumin. The cytotoxic test on murine leukemia P-388 cells used the Microculture Tetrazolium Technique (MTT) method. The results obtained were yellow turmeric curcuminoid compounds using 96% ethanol solvent at an extraction operating time of 9 hours. The largest extract yield was 21.15% with a concentration of 1121.10 ppm, which has activity against murine leukemia P-388 cells with an IC50 of 6.15 g/mL have the potential as anticancer leukemia, and dye analysis at acidic pH (2,4,6) is yellow, while alkaline pH (9,12) is brownish red as a natural food coloring.Abstrak: Penelitian ekstraksi kurkuminoid dari ekstrak etanol kunyit kuning (Curcuma longa L) dan uji aktivitasnya terhadap sel murine leukimia P-388 telah dilakukan. Penelitian ini bertujuan untuk mengetahui rendemen, konsentrasi pelarut, aktivitas sel murine leukemia P-388 dan pH terhadap jumlah kurkuminoid yang dihasilkan pada ekstrak etanol. Kurkuminoid diperoleh dengan proses ekstraksi dengan metode sokletasi menggunakan pelarut etanol 70 dan 96% dengan perbandingan sampel dan pelarut 1:8 variasi waktu operasi selama 3, 6, 9 dan 12 jam. Ekstrak kurkuminoid diukur absorbansi untuk mengetahui konsentrasi kurkumin. Pengujian sitotoksik terhadap sel murine leukimia P-388 dengan metode Microculture Tetrazolium Technique (MTT). Hasil yang diperoleh senyawa kurkuminoid kunyit kuning menggunakan pelarut etanol 96% pada waktu operasi ekstraksi 9 jam rendemen ekstrak terbesar 21,15% dengan konsentrasi 1121,10 ppm, memiliki aktivitas terhadap sel murine leukimia P-388 dengan IC50 sebesar 6,15 μg/mL berpotensi sebagai antikanker leukemia, dan analisis zat warna pada pH asam (2,4,6) berwarna kuning, pada pH basa (9,12 ) berwarna merah kecoklatan sebagai pewarna alami makananan.
Hydrodeoxygenation of Castor Oil As an Alternative Source of Biohydrocarbon Using Nickel Catalyst Loaded On Hzsm-5 Zeolite
Authors: Saragih Muhammad Abimansyah , Hasibuan Muhammad Irvan , Simangunsong Loren , Pulungan Ahmad Nasir , Sihombing Junifa Layla 
Published: September 2023

Abstract: The need for energy continues to increase along with rapid population growth. Fuel is one of the most critical energy sectors. However, the limited availability of fossil fuels and the issue of air pollution have prompted various studies to find alternative fuels that are renewable and environmentally friendly. In this study, the conversion of castor oil into biohydrocarbons through the hydrodeoxygenation (HDO) process using the HZSM-5 catalyst loaded with Ni (Ni/HZSM-5) aims to produce biohydrocarbon products as a component of liquid fuel. This research has been carried out in 3 main stages, including: 1) Catalyst preparation; 2) Catalyst characterization; and 3) Activity and selectivity test of HZSM-5 catalyst and Ni/HZSM-5 in the hydrodeoxygenation process of castor oil at reaction temperatures of 350 oC, 375 oC, and 400 oC. The conversion results of castor oil using HZSM-5 and Ni/HZSM-5 catalysts were 3.23%, 25.65%, 43.72%, and 13.78%, 35.03%, 71.01%, respectively. From the GC-MS analysis data on the product at 400 oC, the selectivity of HZSM-5 and Ni/HZSM-5 was 20.02% and 23.71% for the kerosene fraction, as well as 15.79% and 11.01% for the gasoil fraction, respectively.Abstrak: Kebutuhan energi terus meningkat seiring dengan pertumbuhan jumlah penduduk yang sangat pesat. Salah satu sektor energi yang paling dibutuhkan adalah bahan bakar minyak. Namun kesediaan bahan bakar fosil yang terbatas dan isu pencemaran polusi udara, mendorong berbagai penelitian untuk menemukan alternatif bahan bakar yang terbarukan dan ramah lingkungan. Dalam penelitian ini, konversi minyak jarak menjadi biohidrokarbon melalui proses hidrodeoksigenasi (HDO) menggunakan katalis HZSM-5 teremban logam Ni (Ni/HZSM-5) bertujuan untuk menghasilkan produk biohidrokarbon sebagai komponen bahan bakar cair. Penelitian ini telah dilakukan dengan 3 tahapan utama yaitu 1) Preparasi katalis, 2) Karakterisasi katalis, 3) Uji aktivitas dan selektifitas katalis HZSM-5 serta Ni/HZSM-5 dalam proses hidrodeoksigenasi minyak biji jarak dengan temperatur proses 350 oC, 375 oC, dan 400 oC. Hasil konversi minyak biji jarak dengan menggunakan katalis HZSM-5 dan katalis Ni/HZSM-5 berturut-turut sebesar 3.23%, 25.65%, 43.72% dan 13.78%, 35.03%, 71.01%. Dari data analisis GC-MS produk di suhu 400 oC diperoleh selektivitas katalis HZSM-5 dan katalis Ni/HZSM-5 berturut-turut adalah 20.02% dan 23.71% untuk fraksi kerosene, serta 15.79% dan 11.01% untuk fraksi gasoil.
Gestión estratégica de los emprendimientos femeninos del sector artesanal, priorizado en la ruta competitiva del departamento de Sucre
Authors: Araque Geney Erika Astrid , Álvarez Contreras Diana Esther 
Published: September 2023

Objetivo: Esta investigación tuvo como objetivo identificar el estado actual de los emprendimientos femeninos del sector artesanal, sector que ha sido priorizado en la ruta de competitividad del departamento de Sucre.
Diseño/metodología: El diseño metodológico consideró una parte cualitativa (entrevistas semiestructuradas) y una parte cuantitativa (encuesta con preguntas cerradas en escala tipo Likert de 5 puntos). El periodo de recolección de la información estuvo comprendido entre julio y octubre del año 2021 y, para el análisis de esta, se utilizó estadística descriptiva y análisis narrativo. La población se conformó por el grupo de microempresarias del sector artesanal ubicadas en los municipios de Morroa, Sampúes, San Onofre y Sincelejo, en el departamento de Sucre.
Resultados: Los resultados obtenidos en la investigación evidenciaron que los emprendimientos femeninos enfrentan dificultades externas e internas que se convierten en limitantes para su crecimiento organizacional; además, los retos y cambios que actualmente impulsan el crecimiento y desarrollo empresarial, las obligan a realizar un diagnóstico de sus procesos organizacionales, talento humano, producción, comercialización, servicios y tipos de mercados, esto con el fin de identificar las debilidades, fortalezas, amenazas y oportunidades, para, así, determinar y poner en práctica estrategias que permitan impulsar su crecimiento y mejorar su competitividad.
Conclusiones: El análisis permite concluir que los emprendimientos femeninos artesanales requieren de apoyo a nivel organizacional, además de poder visibilizar el trabajo realizado por las mujeres artesanas desde el ámbito empresarial.
Originalidad: La investigación se diferencia de otros estudios hechos alrededor del tema, ya que contempla el papel de la mujer artesana como empresaria; además, muestra la realidad del sector artesanal el cual, a pesar de que se encuentra en desventaja con otros sectores, aporta al desarrollo empresarial, económico y social del departamento de Sucre, en especial a la sostenibilidad de las tradiciones culturales.
Charles J. Hirsch, Controller, Golden Nugget Casino: Rolling the Dice on Statistical Sampling and Analysis
Authors: Boylan Scott J. 
Published: September 2023

ABSTRACT
Charles J. Hirsch was an accountant and controller for the Golden Nugget casino from 1950 to 1970. He contributed to a movement in the 1950s and 1960s to advance the use of statistical sampling and analysis in the accounting profession. This manuscript is based on analysis of Hirsch’s professional papers, held at the University of Nevada, Las Vegas, Libraries Special Collections and Archives. Hirsch used statistical sampling and analysis at Golden Nugget when statistical techniques had not yet been widely accepted or implemented by practicing accountants and auditors. Beginning in 1959, Hirsch made numerous conference presentations describing his work. In addition, Hirsch explicitly challenged the accounting profession to follow his lead and integrate statistical sampling and analysis into existing practice. In doing so, he joined an exclusive group of individuals, including Robert Trueblood, who were early advocates for using statistical techniques to improve the practice of accounting and auditing.
Do Adverse Opinions on Internal Control over Financial Reporting Lead to Changes in Reporting Format?
Authors: Strawser Jerry R. 
Published: September 2023

SYNOPSIS
This study examines whether the format of audit reports on financial statements and internal control over financial reporting (ICFR) changes in response to the disclosure of one or more material weaknesses in ICFR. The results indicate that (1) reporting format changes are more likely when adverse opinions are issued on ICFR and (2) formats are more likely to change from a combined report to separate reports than vice versa. Supplemental analysis reveals that format changes to separate reports do not result in more favorable market perceptions but do result in marginally lower levels of auditor dismissal/change. These findings indicate that auditors have incentives to acquiesce to client requests to change reporting formats, even though such changes do not result in more favorable market perceptions.
Data Availability: Data are available from public resources noted in the text.
JEL Classifications: M41; M42.
Diversity at Work: Firms’ Strategic Responses to Mandatory Diversity Disclosure
Authors: Oelrich Sebastian , Siebold Nicole , Ketelhut Klemens 
Published: September 2023

SYNOPSIS
Diversity has emerged as a topic of increasing organizational and legislative relevance. Despite forming a burgeoning research field in accounting, little is known about how organizations respond to diversity disclosure legislation. In this paper, we study the introduction of diversity disclosure legislation in the European Union that mandates corporate diversity disclosures, and we analyze how 30 large German companies disclose diversity in their annual reports. Drawing on institutional theory and Oliver’s (1991) seminal work on strategic responses to institutional processes, our analysis reveals four mandatory reporting responses: dismissal, concealment, imitation, and transcendence. Overall, our findings show that although diversity has been institutionalized into organizational environments by the European Union through legislative action, organizational responses vary, from resistance to passive conformity or proactive compliance. With these findings, our study adds to the emergent diversity accounting literature, and we conclude by highlighting implications of our work for policymakers, managers, and researchers.
Data Availability: Data are available from the public sources cited in the text.
Men’s Experiences of Paternity Leaves in Accounting Firms
Authors: Garnier Claire , Mangen Claudine , Nortier Edwige 
Published: September 2023

SYNOPSIS
Accounting researchers and practitioners have made strides in addressing persistent gender inequalities in the accounting profession. However, these efforts have largely sidestepped men and masculinities. Our study considers the role of men and masculinities in gender inequalities by exploring how men in accounting experience paternity leaves. We conduct interviews with 13 men in audit firms in France. We find that fathers are reluctant to take leaves, which they view as vacation periods incompatible with their professional work. They see audit firms as offering less support to fathers than mothers, with support for fathers growing but still marginal. Finally, they experience a variety of emotions, including positive emotions around fatherhood and negative emotions around difficulties in reconciling fatherhood with professional responsibilities and paternity leaves. Practically, our findings imply that to address gender inequalities further, accounting firms need to change the norms around care work, including paternity leaves.
Use of artificial intelligence large language models as a clinical tool in rehabilitation medicine: a comparative test case
Authors: Zhang Liang , Tashiro Syoichi , Mukaino Masahiko , Yamada Shin 
Published: September 2023

Objective: To explore the potential use of artificial intelligence language models in formulating rehabilitation prescriptions and International Classification of Functioning, Disability and Health (ICF) codes.
Design: Comparative study based on a single case report compared to standard answers from a textbook.
Subjects: A stroke case from textbook.
Methods: Chat Generative Pre-Trained Transformer-4 (ChatGPT-4)was used to generate comprehensive medical and rehabilitation prescription information and ICF codes pertaining to the stroke case. This information was compared with standard answers from textbook, and 2 licensed Physical Medicine and Rehabilitation (PMR) clinicians reviewed the artificial intelligence recommendations for further discussion.
Results: ChatGPT-4 effectively formulated rehabilitation prescriptions and ICF codes for a typical stroke case, together with a rationale to support its recommendations. This information was generated in seconds. Compared with standard answers, the large language model generated broader and more general prescriptions in terms of medical problems and management plans, rehabilitation problems and management plans, as well as rehabilitation goals. It also demonstrated the ability to propose specified approaches for each rehabilitation therapy. The language model made an error regarding the ICF category for the stroke case, but no mistakes were identified in the ICF codes assigned.
Conclusion: This test case suggests that artificial intelligence language models have potential use in facilitating clinical practice and education in the field of rehabilitation medicine.
Vision system for monitoring process of winding cylindrical products with a carbon bundle
Authors: Сарамуд Михаил , Спирин Евгений , Талай Евгений , Пикалов Яков 
Published: September 2023

The problem of control of a correct laying of carbon bundle on a mandrel is considered. A mandrel in the form of a cylindrical pipe is considered in the article. Software has been developed for automated analysis of controlled parameters (distances between points). The
results obtained are preliminary and can be improved by: optimizing the camera position and lighting; taking into account camera distortion parameters; formation of a development of the surface of the sharpening with bundles.
Tratamiento de cicatrices con toxina botulínica: grado de evidencia científica
Authors: Alonso Arroyo Verónica , Barnes Marañón Sarah , Forero Torres Alexander , Granell Suarez Cristina , Jiménez Crespo Victoria 
Published: September 2023

Las cicatrices queloides representan el mayor grado de inestetismo del espectro de la hipertrofia de la cicatriz y constituyen un verdadero desafío clínico. Se han descrito numerosas estrategias terapéuticas dirigidas a este tipo de cicatrices, como cirugía, láser, radiofrecuencia e infiltración, entre otras. No obstante, el enfoque terapéutico ideal no ha sido alcanzado hasta el momento.
Recientemente, se ha publicado el empleo de la Toxina Botulínica tipo A (BoNT-A) como parte del tratamiento de las cicatrices queloides con resultados controvertidos. Se presenta una revisión de la evidencia científica de los estudios que comparaban el empleo de la BoNT-A con el uso de corticoides intralesionales, así como el mecanismo de acción y los efectos secundarios de la misma.
Los resultados de las revisiones sistemáticas para la prevención y/o tratamiento de la cicatrización hipertrófica o queloidea con BoNT-A, no muestran una evidencia científica consistente. Además, es complicado obtener datos concluyentes debido al pequeño tamaño de las cohortes, la dificultad para extrapolar los resultados de la experimentación animal a la población general y a la heterogeneidad existente en los diferentes estudios.
La evidencia científica considera que es posible realizar un uso "off- label” de la BoNT-A puesto que es eficaz y segura como tratamiento para prevenir o mejorar las cicatrices inestéticas. Por otro lado, a pesar de que los corticoides podrían ser superiores a la BoNT-A en algunos aspectos, parece que los efectos secundarios asociados a su uso podrían evitarse con el uso de la toxina botulínica.