bluuebunny/crossref_metadata_2025_split huggingface dataset:
Haemophilus influenzae and Moraxella catarrhalis in sputum of severe asthma with inflammasome and neutrophil activation
Authors: Versi Ali , Ivan Fransiskus Xaverius , Abdel‐Aziz Mahmoud I. , Bates Stewart , Riley John , Baribaud Frederic , Kermani Nazanin Zounemat , Montuschi Paolo , Dahlen Sven‐Erik , Djukanovic Ratko , Sterk Peter , Maitland‐Van Der Zee Anke H. , Chotirmall Sanjay H. , Howarth Peter , Adcock Ian M. , Chung Kian Fan ,   U‐BIOPRED consortium
Published: June 2023

AbstractBackgroundBecause of altered airway microbiome in asthma, we analysed the bacterial species in sputum of patients with severe asthma.MethodsWhole genome sequencing was performed on induced sputum from non‐smoking (SAn) and current or ex‐smoker (SAs/ex) severe asthma patients, mild/moderate asthma (MMA) and healthy controls (HC). Data were analysed by asthma severity, inflammatory status and transcriptome‐associated clusters (TACs).Resultsα‐diversity at the species level was lower in SAn and SAs/ex, with an increase in Haemophilus influenzae and Moraxella catarrhalis, and Haemophilus influenzae and Tropheryma whipplei, respectively, compared to HC. In neutrophilic asthma, there was greater abundance of Haemophilus influenzae and Moraxella catarrhalis and in eosinophilic asthma, Tropheryma whipplei was increased. There was a reduction in α‐diversity in TAC1 and TAC2 that expressed high levels of Haemophilus influenzae and Tropheryma whipplei, and Haemophilus influenzae and Moraxella catarrhalis, respectively, compared to HC. Sputum neutrophils correlated positively with Moraxella catarrhalis and negatively with Prevotella, Neisseria and Veillonella species and Haemophilus parainfluenzae. Sputum eosinophils correlated positively with Tropheryma whipplei which correlated with pack‐years of smoking. α‐ and β‐diversities were stable at one year.ConclusionsHaemophilus influenzae and Moraxella catarrhalis were more abundant in severe neutrophilic asthma and TAC2 linked to inflammasome and neutrophil activation, while Haemophilus influenzae and Tropheryma whipplei were highest in SAs/ex and in TAC1 associated with highest expression of IL‐13 type 2 and ILC2 signatures with the abundance of Tropheryma whipplei correlating positively with sputum eosinophils. Whether these bacterial species drive the inflammatory response in asthma needs evaluation.
Proteomic analysis of the esophageal epithelium reveals key features of eosinophilic esophagitis pathophysiology
Authors: Molina‐Jiménez Francisca , Ugalde‐Triviño Lola , Arias‐González Laura , Relaño‐Rupérez Carlos , Casabona Sergio , Pérez‐Fernández María Teresa , Martín‐Domínguez Verónica , Fernández‐Pacheco Jennifer , Laserna‐Mendieta Emilio José , Muñoz‐Hernández Patricia , Arias‐Arias Ángel , Cano Ainara , Muñoz Javier , Lucendo Alfredo J. , Santander Cecilio , Majano Pedro 
Published: June 2023

AbstractBackgroundEosinophilic esophagitis (EoE) is a chronic non‐IgE‐mediated allergic disease of the esophagus. An unbiased proteomics approach was performed to investigate pathophysiological changes in esophageal epithelium. Additionally, an RNAseq‐based transcriptomic analysis in paired samples was also carried out.MethodsTotal proteins were purified from esophageal endoscopic biopsies in a cohort of adult EoE patients (n = 25) and healthy esophagus controls (n = 10). Differentially accumulated (DA) proteins in EoE patients compared to control tissues were characterized to identify altered biological processes and signaling pathways. Results were also compared with a quantitative proteome dataset of the human esophageal mucosa. Next, results were contrasted with those obtained after RNAseq analysis in paired samples. Finally, we matched up protein expression with two EoE‐specific mRNA panels (EDP and Eso‐EoE panel).ResultsA total of 1667 proteins were identified, of which 363 were DA in EoE. RNA sequencing in paired samples identified 1993 differentially expressed (DE) genes. Total RNA and protein levels positively correlated, especially in DE mRNA‐proteins pairs. Pathway analysis of these proteins in EoE showed alterations in immune and inflammatory responses for the upregulated proteins, and in epithelial differentiation, cornification and keratinization in those downregulated. Interestingly, a set of DA proteins, including eosinophil‐related and secreted proteins, were not detected at the mRNA level. Protein expression positively correlated with EDP and Eso‐EoE, and corresponded with the most abundant proteins of the human esophageal proteome.ConclusionsWe unraveled for the first time key proteomic features involved in EoE pathogenesis. An integrative analysis of transcriptomic and proteomic datasets provides a deeper insight than transcriptomic alone into understanding complex disease mechanisms.
Nexus between GHRM and organizational competitiveness: role of green innovation and organizational learning of MNEs
Authors: Obeng Patrick , Dogbe Courage Simon Kofi , Boahen Patience Ama Nyantakyiwaa 
Published: June 2023

AbstractThe focus of this study was to assess the mediating effect of green innovation, in the relationship between green human resources management (GHRM) and organizational competitiveness of manufacturing multinational enterprises (MNEs). The study further looked at the moderating effect of organizational learning in the relationship between GHRM on organizational competitiveness of manufacturing MNEs. The population comprises manufacturing MNEs in Ghana. Through purposive and simple random sampling techniques, 231 manufacturing MNEs were selected for the study. Data was analyzed using frequencies, percentages, mean scores, and Structural Equation Modeling (SEM), using SPSS and SMART‐PLS (Partial Least Square) software. The study concludes that green innovation partially mediates the relationship between GHRM and organizational competitiveness. It was further concluded that organizational learning positively moderates the positive relationship between GHRM and organizational competitiveness. The study recommends that manufacturing MNEs should invest and improve the level of their organizational learning as it not only strengthens the effects of GHRM on organizational competitiveness, but it also directly improves competitiveness. Further, particular attention should also pay to green innovation, as it intervenes the relationship between GHRM and organizational competitiveness.
Promoting the advocacy behavior of customers through corporate social responsibility: The role of brand admiration
Authors: Ahmad Naveed , Ullah Zia , AlDhaen Esra , Siddique Irfan 
Published: June 2023

AbstractGiven that personal source of information is preferred by the customers over company‐generated marketing communications, promoting advocacy behavior among customers is of much importance for every organization. Literature suggests that an organization's corporate social responsibility (CSR) activities significantly influence individual behavior. However, the advocacy behavior of customers (ADB), from a CSR perspective, did not receive due attention. To address this literature gap, the current study attempts to explore the relationship among CSR and ADB with the intervening role of brand admiration (BA). To collect the data, customers of a large fast‐food service organization in Pakistan were approached. The proposed relationships were tested through the structural equation modeling (SEM) technique. The statistical evidence verifies a positive link between CSR and ADB, while BA mediated this relationship. These findings will be supportive to the fast‐food business to realize the critical role of CSR for a meaningful customer‐company relationship in the face of competition.
Dynamics between universities and social entrepreneurs: Insights from a multi‐country project in Latin America
Authors: Samaniego Andrea , Amaya Adriana , Izquierdo Edgar 
Published: June 2023

AbstractResearch has stressed the importance of universities in developing entrepreneurial ecosystems (EEs) and their possible social and economic impacts on society. Concerning this commitment, social entrepreneurs (SEs) favor university actions that facilitate the improvement of their individual capital. However, research on this topic has received little attention. This study investigated how universities contribute to the advancement of EEs. It also examines the mechanisms that universities employ to support SEs. Two survey instruments were administered: one to 418 SEs, and the other to 494 people affiliated with universities. The results indicate that universities can be key actors in EEs because they can mobilize resources aligned with their institutional commitments, including training, facilities, and contact with several stakeholders. Additionally, SEs rely on training opportunities and connections with other stakeholders to implement entrepreneurial initiatives. Accordingly, our study highlights the critical role universities play in the development and survival of SEs.
Recommendations on prevention of infections during chimeric antigen receptor T‐cell and bispecific antibody therapy in multiple myeloma
Authors: Mohan Meera , Chakraborty Rajshekhar , Bal Susan , Nellore Anoma , Baljevic Muhamed , D'Souza Anita , Pappas Peter G. , Berdeja Jesus G. , Callander Natalie , Costa Luciano J. 
Published: June 2023

SummaryChimeric antigen receptor T (CAR T) cell and bispecific antibody therapies have shown unprecedented efficacy in heavily pretreated patients with multiple myeloma (MM). However, their use is associated with a significant risk of severe infections, which can be attributed to various factors such as hypogammaglobulinemia, neutropenia, lymphopenia, T‐cell exhaustion, cytokine‐release syndrome and immune‐effector cell‐associated neurotoxicity syndrome. As these therapies have been recently approved by regulatory agencies, it is crucial to establish practical guidelines for infection monitoring and prevention until robust data from prospective clinical trials become available. To address this issue, a panel of experienced investigators from the Academic Consortium to Overcome Multiple Myeloma through Innovative Trials (COMMIT) developed consensus recommendations for mitigating infections associated with CAR T‐cell and bispecific antibody therapies in MM patients.
Influence of a simulated hurricane on aquatic insect recolonization in the phytotelma ofHeliconia caribaea(Heliconiacaea)
Authors: Everly Jaclyn , Yee Donald 
Published: June 2023

AbstractDisturbances like hurricanes can affect diversity and community composition, which may in turn affect ecosystem function. We examined how a simulated hurricane disturbance affected insect communities inhabiting the phytotelma (plant‐held waters) ofHeliconia caribaeain the Luquillo Experimental Forest of eastern Puerto Rico, a tropical island that frequently experiences hurricanes. We hypothesized that disturbance would alter diversity and that largerHeliconiawould attract more species following disturbance due to the area‐diversity relationship described by the Theory of Island Biogeography. Individual flower parts (bracts) ofHeliconiainflorescences (racemes) were artificially disturbed via removal of existing insect communities, then after refilling with water, cohorts ofHeliconiawere destructively sampled biweekly for 6 weeks to assess recolonization patterns of α (bract level), β, and γ (summed across bracts; raceme level) diversity over time and across raceme sizes. Although we found no support for our hypothesis about the effect of raceme size on recolonization, our hypothesis regarding recolonization patterns over time was supported; species richness, evenness, and abundance of bracts increased directly after the disturbance and then decreased below pre‐disturbance levels, and community composition at the raceme level changed significantly over time during recolonization. β Diversity was also greater in smaller racemes compared to larger racemes, suggesting high heterogeneity across bracts ofHeliconiaracemes exacerbated by raceme size and age. Overall, our results highlight the importance of scale and appropriate measurements of diversity (particularly α) in experiments aiming to extrapolate conclusions about the ecological impacts of disturbances across different habitats and ecosystems.
Retinal microvascular and structural changes in intracranial hypertension patients correlate with intracranial pressure
Authors: Kwapong William Robert , Cao Le , Pan Ruosu , Wang Hang , Ye Chen , Tao Wendan , Liu Junfeng , Wu Bo 
Published: June 2023

AbstractAimsWe aimed to evaluate the retinal microvascular and structural changes in intracranial hypertension (IH) patients compared with an age‐ and sex‐matched control group. We also investigated the association between clinical parameters and retinal changes in IH patients.MethodsIntracranial hypertension patients were divided into eyes with papilledema (IH‐P) and eyes without papilledema (IH‐WP). IH patients underwent lumbar puncture to measure intracranial pressure (ICP); visual acuity was performed using the Snellen chart. Optical coherence tomography (OCT) was used to image and measure the retinal nerve fiber layer (RNFL) and ganglion cell‐inner plexiform layer (GCIPL) while OCT angiography was used to image and measure the superficial vascular complex (SVC) and deep vascular complex (DVC).ResultsIntracranial hypertension patients showed reduced microvascular densities and thinner retinal thicknesses compared with the control group (all p < 0.001). Compared with the control group, IH‐P showed reduced microvascular densities and thinner retinal thicknesses (all p < 0.001). IH‐P showed reduced SVC density and thinner retinal thicknesses when compared with IH‐WP (p = 0.008 for SVC, p = 0.025 for RNFL, and p = 0.018 for GCIPL). ICP correlated with the microvascular densities and GCIPL thickness in IH patients (p = 0.025 for GCIPL, p = 0.004 for SVC, and p = 0.002 for DVC). A significant association of ICP with SVC (p = 0.010) and DVC (p = 0.005) densities were also found in IH‐P.ConclusionsGiven the observed differences in these noninvasive retinal imaging markers, further research into their clinical utility in IH is needed.
Microbial lipopolysaccharide‐induced inflammation contributes to cognitive impairment and white matter lesion progression in diet‐induced obese mice with chronic cerebral hypoperfusion
Authors: Inaba Toshiki , Yamashiro Kazuo , Kurita Naohide , Ueno Yuji , Miyamoto Nobukazu , Hira Kenichiro , Nakajima Sho , Kijima Chikage , Nakaguro Ryohei , Urabe Takao , Hattori Nobutaka 
Published: June 2023

AbstractAimsWhite matter lesions (WMLs) are involved in the pathological processes leading to cognitive decline and dementia. We examined the mechanisms underlying the exacerbation of ischemia‐induced cognitive impairment and WMLs by diet‐induced obesity, including lipopolysaccharide (LPS)‐triggered neuroinflammation via toll‐like receptor (TLR) 4.MethodsWild‐type (WT) and TLR4‐knockout (KO) C57BL/6 mice were fed a high‐fat diet (HFD) or low‐fat diet (LFD), and subjected to bilateral carotid artery stenosis (BCAS). Diet groups were compared for changes in gut microbiota, intestinal permeability, systemic inflammation, neuroinflammation, WML severity, and cognitive dysfunction.ResultsIn WT mice, HFD induced obesity and increased cognitive impairment and WML severity compared with LFD‐fed mice following BCAS. HFD caused gut dysbiosis and increased intestinal permeability, and plasma LPS and pro‐inflammatory cytokine concentrations. Furthermore, HFD‐fed mice had higher LPS levels and higher neuroinflammatory status, including increased TLR4 expression, in WMLs. In TLR4‐KO mice, HFD also caused obesity and gut dysbiosis but did not increase cognitive impairment or WML severity after BCAS. No difference was found between HFD‐ and LFD‐fed KO mice for LPS levels or inflammatory status in either plasma or WMLs.ConclusionInflammation triggered by LPS–TLR4 signaling may mediate obesity‐associated exacerbation of cognitive impairment and WMLs from brain ischemia.
Association between regular physical activity and lower incidence of colorectal cancer in patients with diabetes mellitus: a nationwide cohort study
Authors: Lee Han Hee , Lee Kyu‐na , Kim Jin Su , Cheung Dae Young , Kwon Hyuk‐Sang , Lee Bo‐In , Cho Young‐Seok , Park Soo‐Heon , Han Kyungdo , Kim Jin Il 
Published: June 2023

AbstractAimThe aim of this work was to investigate the association between changes in physical activity (PA) status and the development of colorectal cancer (CRC) in patients with diabetes.MethodThis nationwide population study included 1 439 152 patients with diabetes who underwent a health screening provided by the Korean National Health Insurance Service between January 2009 and December 2012 and a follow‐up screening after 2 years. Based on changes in PA status, participants were categorized into four groups: remained inactive, remained active, active‐to‐inactive and inactive‐to‐active.ResultsDuring the median follow‐up period of 5.2 years, 38 244 new cases of CRC were diagnosed. Compared with the remained inactive group, among the three other groups, the remained active group had the lowest risk of CRC [adjusted hazard ratio (aHR) 0.93; 95% CI 0.90–0.96], followed by the inactive‐to‐active group (aHR 0.97; 95% CI 0.94–1.00) and active‐to‐inactive group (aHR 0.99; 95% CI 0.96–1.02), after adjusting for confounding variables (p = 0.0007). This reduction in cancer incidence in the remained active group was observed for both rectal cancer (aHR 0.87, 95% CI 0.79–0.95) and colon cancer (aHR 0.93, 95% CI 0.90–0.97), irrespective of sex. In terms of the intensity and amount of PA, moderate intensity PA was the most effective, and a positive correlation was found between the amount of PA and the reduction in CRC incidence.ConclusionRegular PA was independently associated with a decreased risk of CRC in patients with diabetes. The intensity and amount of physical activity both play a role in reducing the risk.
Board demographic, structural diversity, and eco‐innovation: International evidence
Authors: Zaman Rashid , Asiaei Kaveh , Nadeem Muhammad , Malik Ihtisham , Arif Muhammad 
Published: June 2023

AbstractResearch question/issueWe examine whether and how board diversity, measured by demographics (i.e., board gender, cultural diversity, tenure, social capital, expertise, and age) and structural diversity (i.e., board independence, size, board seat accumulation‐chair, board compensation, and board meeting frequency), influence corporate eco‐innovation.Research findings/insightsUtilizing a global sample of publicly listed companies for the period 2004–2019, we find that a one‐standard deviation increase in demographic and structural diversity translates into 4.66% and 7.11% higher corporate eco‐innovation, respectively. Furthermore, we discover that demographic and structural diversity promotes eco‐innovation by offsetting the negative effects of political risk. In an additional analysis, we find evidence that, in the absence of greater external monitoring (institutional investors and analyst following), organizations benefit more from the monitoring role of board diversity.Theoretical/academic implicationsBy adopting the concept of “bundling the governance mechanisms,” our study adds to the ongoing discourse about the function of board diversity in addressing corporate climate footprints by offering original evidence that board diversity heterogeneity—demographic and structural diversity—matters for corporate eco‐innovation.Practitioner/policy implicationsGiven the increasing pressure on companies to manage their environmental impacts and carbon footprints, our paper has significant ramifications for those involved in promoting eco‐innovative business practices, such as policymakers, regulators, and practitioners.
Inquiry Letters and Tax Aggressiveness
Authors: Wu Yewei , Zhang Bofu 
Published: June 2023

AbstractThis study examined the impact of inquiry letters on corporate tax aggressiveness based on the special inquiry system in Chinese stock exchanges. It found that the receipt of inquiry letters significantly inhibited tax aggressiveness. The channel through which inquiry letters worked involved a monitoring effect on related‐party transactions. The disincentive effect of inquiry letters on corporate tax aggressiveness was mainly found in firms with overseas operations, low‐quality of internal control, and weak tax enforcement. Examining the textual information in inquiry letters, the results show that more questions and the demand for a specific opinion from the auditor led to a greater disincentive effect. The level of detail in firms' reply letters weakened this disincentive effect. Finally, the disincentive effect of tax aggressiveness was more pronounced when inquiry letters pointed to tax‐related issues.
Longitudinal latent polysubstance use patterns among a cohort of people who use opioids in Vancouver, Canada
Authors: Karamouzian Mohammad , Cui Zishan , Hayashi Kanna , DeBeck Kora , Milloy M.‐J. , Buxton Jane A. , Kerr Thomas 
Published: June 2023

AbstractIntroductionPolysubstance use (PSU) practices are increasing among people who use opioids (PWUO). However, several aspects of longitudinal PSU patterns among PWUO remain understudied. This study aims to identify person‐centred longitudinal patterns of PSU among a cohort of PWUO.MethodsUsing longitudinal data (2005–2018) from three prospective cohort studies including people who use drugs in Vancouver, Canada, we used repeated measures latent class analysis to identify different PSU classes among PWUO. Multivariable generalised estimating equations models weighted by the respective posterior membership probabilities were applied to identify covariates of membership in different PSU classes over time.ResultsOverall, 2627 PWUO (median age at baseline: 36 [quartile 1–3: 25–45]) were included between 2005 and 2018. We found five distinct PSU patterns, including low/infrequent probability of regular substance use (Class 1; 30%), primarily opioid and methamphetamine use (Class 2; 22%), primarily cannabis use (Class 3; 15%), primarily opioid and crack use (Class 4; 29%) and frequent PSU (Class 5; 4%). Membership in Class 2, 4 and 5 was positively associated with several behavioural and socio‐structural adversities.Discussion and ConclusionsFindings of this longitudinal study suggest PSU is the norm among PWUO and highlights the heterogeneous characteristics of PWUO. The diversities within the population of PWUO need to be recognised in addiction care and treatment as well as optimising resource allocation in the response to the overdose crisis.