bluuebunny/crossref_metadata_2025_split huggingface dataset:
Free-view Face Relighting Using a Hybrid Parametric Neural Model on a SMALL-OLAT Dataset
Authors: Wang Youjia , He Kai , Zhou Taotao , Yao Kaixin , Li Nianyi , Xu Lan , Yu Jingyi 
Published: January 2023

AbstractThe development of neural relighting techniques has by far outpaced the rate of their corresponding training data (e.g., OLAT) generation. For example, high-quality relighting from a single portrait image still requires supervision from comprehensive datasets covering broad diversities in gender, race, complexion, and facial geometry. We present a hybrid parametric neural relighting (PN-Relighting) framework for single portrait relighting, using a much smaller OLAT dataset or SMOLAT. At the core of PN-Relighting, we employ parametric 3D faces coupled with appearance inference and implicit material modelling to enrich SMOLAT for handling in-the-wild images. Specifically, we tailor an appearance inference module to generate detailed geometry and albedo on top of the parametric face and develop a neural rendering module to first construct an implicit material representation from SMOLAT and then conduct self-supervised training on in-the-wild image datasets. Comprehensive experiments show that PN-Relighting produces comparable high-quality relighting to TotalRelighting (Pandey et al., 2021), but with a smaller dataset. It further improves shape estimation and naturally supports free-viewpoint rendering and partial skin material editing. PN-Relighting also serves as a data augmenter to produce rich OLAT datasets beyond the original capture.
Genes encoding agrin (AGRN) and neurotrypsin (PRSS12) are associated with muscle mass, strength and plasma C-terminal agrin fragment concentration
Authors: Pratt Jedd , Whitton Laura , Ryan Anthony , Juliusdottir Thorhildur , Dolan Jackie , Conroy Judith , Narici Marco , De Vito Giuseppe , Boreham Colin 
Published: January 2023

Abstract
Although physiological data suggest that neuromuscular junction (NMJ) dysfunction is a principal mechanism underpinning sarcopenia, genetic studies have implicated few genes involved in NMJ function. Accordingly, we explored whether genes encoding agrin (AGRN) and neurotrypsin (PRSS12) were associated with sarcopenia phenotypes: muscle mass, strength and plasma C-terminal agrin fragment (CAF). PhenoScanner was used to determine if AGRN and/or PRSS12 variants had previously been implicated with sarcopenia phenotypes. For replication, we combined genotype from whole genome sequencing with phenotypic data from 6715 GenoFit participants aged 18–83 years. Dual energy X-ray absorptiometry assessed whole body lean mass (WBLM) and appendicular lean mass (ALM), hand dynamometry determined grip strength and ELISA measured plasma CAF in a subgroup (n = 260). Follow-up analyses included eQTL analyses, carrier analyses, single-variant and gene-burden tests. rs2710873 (AGRN) and rs71608359 (PRSS12) associate with muscle mass and strength phenotypes, respectively, in the UKBB (p = 8.9 × 10−6 and p = 8.4 × 10−6) and GenoFit cohort (p = 0.019 and p = 0.014). rs2710873 and rs71608359 are eQTLs for AGRN and PRSS12, respectively, in ≥ three tissues. Compared to non-carriers, carriers of rs2710873 had 4.0% higher WBLM and ALM (both p < 0.001), and 9.5% lower CAF concentrations (p < 0.001), while carriers of rs71608359 had 2.3% lower grip strength (p = 0.034). AGRN and PRSS12 are associated with muscle strength and mass in single-variant analyses, while PRSS12 has further associations with muscle strength in gene-burden tests. Our findings provide novel evidence of the relevance of AGRN and PRSS12 to sarcopenia phenotypes and support existing physiological data illustrating the importance of the NMJ in maintaining muscle health during ageing.
Fixturing technology and system for thin-walled parts machining: a review
Authors: Liu Haibo , Wang Chengxin , Li Te , Bo Qile , Liu Kuo , Wang Yongqing 
Published: January 2023

AbstractDuring the overall processing of thin-walled parts (TWPs), the guaranteed capability of the machining process and quality is determined by fixtures. Therefore, reliable fixtures suitable for the structure and machining process of TWP are essential. In this review, the key role of fixtures in the manufacturing system is initially discussed. The main problems in machining and workholding due to the characteristics of TWP are then analyzed in detail. Afterward, the definition of TWP fixtures is reinterpreted from narrow and broad perspectives. Fixture functions corresponding to the issues of machining and workholding are then clearly stated. Fixture categories are classified systematically according to previous research achievements, and the operation mode, functional characteristics, and structure of each fixture are comprehensively described. The function and execution mode of TWP fixtures are then systematically summarized and analyzed, and the functions of various TWP fixtures are evaluated. Some directions for future research on TWP fixtures technology are also proposed. The main purpose of this review is to provide some reference and guidance for scholars to examine TWP fixtures.
Application of deep learning-based super-resolution to T1-weighted postcontrast gradient echo imaging of the chest
Authors: Maennlin Simon , Wessling Daniel , Herrmann Judith , Almansour Haidara , Nickel Dominik , Kannengiesser Stephan , Afat Saif , Gassenmaier Sebastian 
Published: January 2023

AbstractObjectivesA deep learning-based super-resolution for postcontrast volume-interpolated breath-hold examination (VIBE) of the chest was investigated in this study. Aim was to improve image quality, noise, artifacts and diagnostic confidence without change of acquisition parameters.Materials and methodsFifty patients who received VIBE postcontrast imaging of the chest at 1.5 T were included in this retrospective study. After acquisition of the standard VIBE (VIBES), a novel deep learning-based algorithm and a denoising algorithm were applied, resulting in enhanced images (VIBEDL). Two radiologists qualitatively evaluated both datasets independently, rating sharpness of soft tissue, vessels, bronchial structures, lymph nodes, artifacts, cardiac motion artifacts, noise levels and overall diagnostic confidence, using a Likert scale ranging from 1 to 4. In the presence of lung lesions, the largest lesion was rated regarding sharpness and diagnostic confidence using the same Likert scale as mentioned above. Additionally, the largest diameter of the lesion was measured.ResultsThe sharpness of soft tissue, vessels, bronchial structures and lymph nodes as well as the diagnostic confidence, the extent of artifacts, the extent of cardiac motion artifacts and noise levels were rated superior in VIBEDL(allP < 0.001).There was no significant difference in the diameter or the localization of the largest lung lesion in VIBEDLcompared to VIBES. Lesion sharpness as well as detectability was rated significantly better by both readers with VIBEDL(bothP < 0.001).ConclusionThe application of a novel deep learning-based super-resolution approach in T1-weighted VIBE postcontrast imaging resulted in an improvement in image quality, noise levels and diagnostic confidence as well as in a shortened acquisition time.
Dynamic Movement Primitives Based Robot Skills Learning
Authors: Kong Ling-Huan , He Wei , Chen Wen-Shi , Zhang Hui , Wang Yao-Nan 
Published: January 2023

AbstractIn this article, a robot skills learning framework is developed, which considers both motion modeling and execution. In order to enable the robot to learn skills from demonstrations, a learning method called dynamic movement primitives (DMPs) is introduced to model motion. A staged teaching strategy is integrated into DMPs frameworks to enhance the generality such that the complicated tasks can be also performed for multi-joint manipulators. The DMP connection method is used to make an accurate and smooth transition in position and velocity space to connect complex motion sequences. In addition, motions are categorized into different goals and durations. It is worth mentioning that an adaptive neural networks (NNs) control method is proposed to achieve highly accurate trajectory tracking and to ensure the performance of action execution, which is beneficial to the improvement of reliability of the skills learning system. The experiment test on the Baxter robot verifies the effectiveness of the proposed method.
Bone Marrow Mesenchymal Stem Cells Reversed Ovarian Aging-related m6A RNA Methylation Modification Profile in Aged Granulosa Cells
Authors: Tian Chuan , An Yuanyuan , Zhao Jing , Zhu Xiangqing , Wei Wei , Ruan Guangping , Li Ye , Pan Xinghua 
Published: January 2023

Abstract
Background
Ovarian ageing causes endocrine disturbances and the degeneration of systemic tissue and organ functions to seriously affect women's physical and mental health, and effective treatment methods are urgently needed. Based on our previous studies using juvenile rhesus monkey bone marrow mesenchymal stem cells (BMMSCs) to treat ovarian ageing in rhesus monkey, we found that BMMSCs improved ovarian structure and function. This study continues to explore the mechanism by which BMMSCs reversed granulosa cell (GC) ageing.

Methods
A GC ageing model and coculture system of BMMSCs were established, changes in the level of the N6-methyladenosine (m6A) methylation modification were detected, m6A-modified RNA immunoprecipitation sequencing (MeRIP-seq) were performed, correlations between m6A peaks and mRNA expression were determined, and the expression of hub genes was identified using Q-PCR, immunofluorescence staining, and western blot.

Results
Our results showed that H2O2 successfully induced GC ageing and that BMMSCs reversed measures of GC ageing. BMMSCs increased the expression of the FTO protein and reduced the overall level of m6A. We identified 797 m6A peaks (348 hypomethylated and 449 hypermethylated peaks) and 817 differentially expressed genes (DEGs) (412 upregulated and 405 downregulated) after aged GCs were cocultured with BMMSCs, which significantly associated with ovarian function and epigenetic modification. The epigenetic repressive mark and important cell cycle regulator lysine demethylase 8 (KDM8) was downregulated at both the mRNA and protein levels, histone H3 was upregulated in aged GCs after BMMSC coculture, and KDM8 was upregulated after FTO was inhibited through FB23.

Conclusions
Our study revealed an essential role for m6A in BMMSCs in reversing GC ageing, and FTO regulated KDM8 mediates histone H3 changes may as a novel regulatory mechanism in BMMSCs to reverse GC ageing.

Graphical Abstract
Asparaginyl endopeptidase contributes to cetuximab resistance via MEK/ERK signaling in RAS wide-type metastatic colorectal cancer
Authors: Xu Xiaojing , Liu Mengling , Peng Ke , Yu Yiyi , Liu Tianshu 
Published: January 2023

Abstract
Background
Cetuximab, a monoclonal antibody targeting epidermal growth factor receptor (EGFR), is effective for RAS wild-type metastatic colorectal cancer (mCRC) patients. However, cetuximab resistance often occur and the mechanism has not been fully elucidated. The purpose of this study was to investigate the role of asparaginyl endopeptidase (AEP) in cetuximab resistance.

Methods
Differentially expressed genes between cetuximab responders and non-responders were identified by analyzing the gene expression profile GSE5851, retrieved from Gene Expression Omnibus (GEO). The potential genes were further validated in cetuximab-resistant CRC cell lines. The expression of AEP in the peripheral blood and tumor tissues of mCRC patients in our hospital were detected by enzyme-linked immunosorbent assay (ELISA) and immunohistochemistry, respectively. The survival analysis was carried out by Kaplan–Meier method. The function and associated pathways of AEP were further investigated by lentivirus transfection, CCK8 assay, colony formation assay, real-time polymerase chain reaction (qPCR) and western blot.

Results
Through bioinformatics analysis, we found that the expression of AEP gene was related to progress free survival (PFS) of mCRC patients treated with cetuximab alone (P = 0.00133). The expression of AEP was significantly higher in the cetuximab-resistant CRC cell lines, as well as in mCRC patients with shorter PFS treated with cetuximab-containing therapy. Furthermore, AEP could decrease the sensitivity of CRC cells to cetuximab in vitro. And the phosphorylation level of MEK and ERK1/2 was increased in AEP overexpression cells. The downregulation of AEP using specific inhibitors could partially restore the sensitivity of CRC cells to cetuximab.

Conclusion
The higher expression of AEP could contribute to the shorter PFS of cetuximab treatment in mCRC. The reason might be that AEP could promote the phosphorylation of MEK/ERK protein in the downstream signal pathway of EGFR.
Oral health and mental health in healthy adults, a topic of primary prevention and health care, empirical results from two online studies
Authors: Herbert Cornelia 
Published: January 2023

AbstractOral health is an important, yet often neglected aspect of health and well-being. Among geriatric populations, oral diseases, poor oral health, and reduced oral hygiene behavior are major comorbid factors of geriatric diseases such as dementia, cardiovascular diseases, or mental health conditions. However, little is known so far about the relationships between oral health and mental health in the younger adult population, who is yet not suffering from any disorder. In the present manuscript the results of two online studies, online study 1, n = 133, all-female sample and online study 2: n = 29, mixed gender sample, are reported that investigate the relationship between self-reported oral health impairments and preclinical symptoms of mental disorders including self-reported symptoms associated with depression or eating disorders as well as self-reported perceived stress and behavior change related to the COVID-19 pandemic. The results of both studies support links between self-reported oral health impairments, self-reported depressive symptoms (including anxiety and current affect) and symptoms related to eating disorders (such as bulimic behavior, body dissatisfaction or drive for thinness) among young adults and suggest that perceived stress may contribute to both, impaired oral health and impaired mental health in young adults (women and men).
Neoadjuvant chemotherapy using nanoparticle albumin-bound paclitaxel plus trastuzumab and pertuzumab followed by epirubicin and cyclophosphamide for operable HER2-positive primary breast cancer: a multicenter phase II clinical trial (PerSeUS-BC04)
Authors: Futamura Manabu , Ishihara Kazuhiro , Nagao Yasuko , Ogiso Atsuko , Niwa Yoshimi , Nakada Takumi , Kawaguchi Yoshihiro , Ikawa Ai , Kumazawa Iwao , Mori Ryutaro , Kitazawa Mai , Hosono Yoshiki , Kuno Masashi , Kawajiri Mana , Nakakami Akira , Takeuchi Makoto , Morikawa Akemi , Tokumaru Yoshihisa , Katagiri Yasuo , Asano Yoshimasa , Mushika Yoshinori , Shimokawa Toshio , Matsuhasih Nobuhisa 
Published: January 2023

Abstract
Background
Nanoparticle albumin-bound paclitaxel (nab-PTX) is a promising antibody partner for anti-human epidermal growth factor receptor 2 (HER2). We performed neoadjuvant chemotherapy (NAC) for HER2-positive breast cancer (BC) using nab-PTX plus trastuzumab (T-mab) and pertuzumab (P-mab), followed by epirubicin and cyclophosphamide (EC).

Methods
In this multicenter phase II clinical trial (January 2019–July 2020), patients with stage I (T1c)-IIIB HER2-positive primary BC were treated with four cycles of nab-PTX plus T-mab and P-mab, followed by four cycles of EC. The primary endpoint was the pathological complete response (pCR) rate. Secondary endpoints were clinical response rate (RR), adverse events (AE), and tumor-infiltrating lymphocytes (TILs) in biopsy samples.

Results
In total, 43 patients were enrolled (mean age, 54 years). Twenty-two patients had HER2, and 21 patients had luminal/HER2-subtypes. The overall pCR rate was 53.5% (23/43, 95% CI: 42.6–64.1%, p = 0.184), whilst the pCR for HER2 was 68.2% (15/22, 95% CI: 45.1–86.1) and 38.1% for luminal/HER2 (8/21, 95% CI: 18.1–61.6%). The RR was 100% [clinical (c) CR:25, partial response (PR): 18]. AEs (≥ G3) included neutropenia (23.3%), leukopenia (7.0%), liver dysfunction (7.0%), and peripheral neuropathy (4.7%) when nab-PTX was administered. EC administration resulted in leukopenia (34.2%), neutropenia (31.6%), and febrile neutropenia (15.8%). The TILs in preoperative biopsy samples were significantly higher in pCR compared to non-pCR samples.

Conclusion
Nab-PTX plus T-mab and P-mab induced a high pCR rate in HER2-positive BC, particularly in the HER2-subtype. Given that AEs are acceptable, this regimen is safe and acceptable as NAC for HER2-positive BC.
Be Kind to Yourself: the Implications of Momentary Self-Compassion for Affective Dynamics and Well-Being in Daily Life
Authors: Mey Lara Kristin , Wenzel Mario , Morello Karolina , Rowland Zarah , Kubiak Thomas , Tüscher Oliver 
Published: January 2023

Abstract

Objectives
While self-compassion (SC) has mostly been understood as a stable trait-like property, growing evidence suggests that it may fluctuate over time within a given individual. However, little is known on how these fluctuations relate to affective well-being and affective dynamics, such as emotional inertia and stress reactivity in daily life.

Methods
A sample of 119 non-clinical individuals (mean age: 31.3 years, 53.8% female) completed a 7-day smartphone-based ecological momentary assessment study with six semi-random signals per day. With each signal, individuals reported their momentary positive affect (PA) and negative affect (NA), recent SC, and occurrence and perceived strain of daily hassles since the last signal.

Results
Whenever individuals reported higher recent SC than usual, they experienced higher momentary PA and lower momentary NA. Moreover, higher recent SC related to lower stress reactivity in terms of lower decrease of PA and lower increase of NA following the experience of daily hassles. No associations between SC and emotional inertia were found. When distinguishing between the positive components (SC-Pos) and negative components (SC-Neg) of SC, SC-Neg (compared to SC-Pos) was more strongly connected to NA, while SC-Pos and SC-Neg were similarly connected to PA. SC-Pos was associated with an attenuated NA stress reactivity, and SC-Neg with an increased NA stress reactivity. SC-Pos and SC-Neg did not significantly moderate PA stress reactivity nor emotional inertia.

Conclusions
Results show that the benefits of SC for well-being and stress reactivity may unfold whenever we treat ourselves with compassion, irrespective of how self-compassionate we are in general.
The impact of postmastectomy radiotherapy on cT1-2N1 breast cancer patients with ypN0 after neoadjuvant chemotherapy: a retrospective study based on real-world data
Authors: Dai Yuran , Ma Shishi , Lan Ailin , Wang Yihua , Wang Yu , Jin Yudi , Ding Nan , Jiang Linshan , Tang Zhenrong , Yin Xuedong , Peng Yang , Liu Shengchun 
Published: January 2023

Abstract
Background
The role of postmastectomy radiation therapy (PMRT) in clinical T1-2N1 breast cancer patients who achieve axillary pathological complete response (ypN0) after neoadjuvant chemotherapy (NAC) is controversial.

Methods
Data from cT1-2N1 breast cancer patients who converted to ypN0 after NAC and subsequent surgery were retrospectively analyzed. Disease-free survival (DFS) and overall survival (OS) were estimated using the Kaplan‒Meier method. Univariate and multivariate Cox regression models were applied to investigate the correlations between clinical or pathological parameters and survival.

Results
From 2012–2019, we identified 116 cases for analysis, including 31 (26.7%) who received PMRT and 85 (73.3%) who did not. At a median follow-up time of 56.4 months, the 5-year DFS and OS rates were 90.2% and 96.7% with PMRT and 93.7% and 97.3% without PMRT, respectively. PMRT did not affect either DFS (p = 0.234) or OS (p = 0.878). On multivariate analyses, no differences in DFS or OS between the two groups were detected, taking into consideration the following factors: age, molecular subtype, Ki67 index, cT stage, and in-breast pathologic complete response (DFS: HR 2.260; 95% CI 0.465–10.982; p = 0.312. OS: HR 1.400; 95% CI 0.138–14.202; p = 0.776). This nonsignificant difference was also consistent in subgroup analyses (all p > 0.05).

Conclusions
PMRT has limited ability to confer DFS or OS benefits for cT1-2N1 breast cancer patients who achieved axillary pathological complete response after NAC and total mastectomy. It is imperative to conduct prospective studies to investigate the safety and feasibility of omitting PMRT.
Trial registration: This research was approved by the Ethics Committee of The First Affiliated Hospital of Chongqing Medical University (ID: No. 2021–442).
Understanding the phenotypic spectrum and family experiences of XYY syndrome: Important considerations for genetic counseling
Authors: Jodarski Colleen , Duncan Rylee , Torres Erin , Gore Rachel , Raznahan Armin , Similuk Morgan 
Published: January 2023

AbstractXYY syndrome is characterized by a variable neurodevelopmental phenotype, with features including developmental delays, cognitive impairments, and an increased risk for mental health conditions. There are two recent developments that have primarily motivated this review. The first is the increased use of non-invasive prenatal screening (NIPS), which will likely result in more individuals being diagnosed with XYY prenatally. As such, health care providers (HCPs) both within genetics and outside of the specialty are more likely to encounter this diagnosis in the future. The second is advances in the understanding of the phenotypic variability of XYY through biobank and deep phenotyping efforts. As the phenotypic spectrum of XYY syndrome continues to expand, families will face greater uncertainty when receiving this diagnosis. Given both of these developments, HCPs will need to have up-to-date and accurate information about XYY to better counsel families. Furthermore, the ability to employ effective counseling techniques, such as anticipatory guidance, will aid in supporting and guiding families through the diagnostic journey. This review aims to provide insight on the neurodevelopmental and psychosocial aspects of XYY syndrome by discussing current research and borrowing from the relevant psychosocial literature of other genetic conditions. In this way, we hope to equip HCPs with the ultimate goal of improving the care and support provided to individuals with XYY and their families.