bluuebunny/crossref_metadata_2025_split huggingface dataset:
The 2023 Impact of Inflammatory Bowel Disease in Canada: Direct Health System and Medication Costs
Authors: Kuenzig M Ellen , Coward Stephanie , Targownik Laura E , Murthy Sanjay K , Benchimol Eric I , Windsor Joseph W , Bernstein Charles N , Bitton Alain , Jones Jennifer L , Lee Kate , Peña-Sánchez Juan-Nicolás , Rohatinsky Noelle , Ghandeharian Sara , Im James H B , Jogendran Rohit , Meka Saketh , Weinstein Jake , Jones May Tyrel , Jogendran Manisha , Tabatabavakili Sahar , Hazan Elias , Hu Malini , Osei Jessica Amankwah , Khan Rabia , Wang Grace , Browne Mira , Davis Tal , Goddard Quinn , Gorospe Julia , Latos Kate , Mason Kate , Kerr Jack , Balche Naji , Sklar Anna , Kaplan Gilaad G 
Published: September 2023

Abstract
Healthcare utilization among people living with inflammatory bowel disease (IBD) in Canada has shifted from inpatient management to outpatient management; fewer people with IBD are admitted to hospitals or undergo surgery, but outpatient visits have become more frequent. Although the frequency of emergency department (ED) visits among adults and seniors with IBD decreased, the frequency of ED visits among children with IBD increased. Additionally, there is variation in the utilization of IBD health services within and between provinces and across ethnocultural and sociodemographic groups. For example, First Nations individuals with IBD are more likely to be hospitalized than the general IBD population. South Asian children with Crohn’s disease are hospitalized more often than their Caucasian peers at diagnosis, but not during follow-up. Immigrants to Canada who develop IBD have higher health services utilization, but a lower risk of surgery compared to individuals born in Canada. The total direct healthcare costs of IBD, including the cost of hospitalizations, ED visits, outpatient visits, endoscopy, cross-sectional imaging, and medications are rising rapidly. The direct health system and medication costs of IBD in Canada are estimated to be $3.33 billion in 2023, potentially ranging from $2.19 billion to $4.47 billion. This is an increase from an estimated $1.28 billion in 2018, likely due to sharp increases in the use of biologic therapy over the past two decades. In 2017, 50% of total direct healthcare costs can be attributed to biologic therapies; the proportion of total direct healthcare costs attributed to biologic therapies today is likely even greater.
The 2023 Impact of Inflammatory Bowel Disease in Canada: Mental Health and Inflammatory Bowel Disease
Authors: Graff Lesley A , Geist Rose , Kuenzig M Ellen , Benchimol Eric I , Kaplan Gilaad G , Windsor Joseph W , Bitton Alain , Coward Stephanie , Jones Jennifer L , Lee Kate , Murthy Sanjay K , Peña-Sánchez Juan-Nicolás , Targownik Laura E , Jannati Nazanin , Jones May Tyrel , Akhtar Sheekha Tasbeen , Davis Tal , Weinstein Jake , Dahlwi Ghaida , Im James H B , Amankwah Osei Jessica , Rohatinsky Noelle , Ghandeharian Sara , Goddard Quinn , Gorospe Julia , Gertsman Shira , Louis Michelle , Wagner Richelle , Brass Colten , Sanderson Rhonda , Bernstein Charles N 
Published: September 2023

Abstract
Psychiatric disorders are 1.5 to 2 times more prevalent in persons with inflammatory bowel disease (IBD) than in the general population, with pooled prevalence estimates of 21% for clinical anxiety and 15% for depression. Rates are even higher when considering mental health symptoms, as nearly one-third of persons with IBD experience elevated anxiety symptoms and one-quarter experience depression symptoms. Rates of these symptoms were much higher during periods of disease activity, more common in women than men, and more common in Crohn’s disease than ulcerative colitis. There is robust evidence of the detrimental effects of comorbid depression and anxiety on the subsequent course of IBD based on longitudinal studies tracking outcomes over time. However, psychiatric disorders and IBD have bidirectional effects, with each affecting risk of the other. Elevated mental health concerns have been consistently associated with greater healthcare utilization and costs related to IBD. There is some signal that low resilience in adolescence could be a risk factor for developing IBD and that enhancing resilience may improve mental health and intestinal disease outcomes in IBD. Psychological therapies used to treat anxiety and depression occurring in the context of IBD have been shown to significantly improve the quality of life for persons with IBD and reduce anxiety and depression. There is less evidence in regard to the impact of psychotropic medications on mental health or disease outcomes in persons with IBD. There is consensus, however, that mental health must be addressed as part of comprehensive IBD care for children and adults.
The 2023 Impact of Inflammatory Bowel Disease in Canada: Special Populations—Children and Adolescents with IBD
Authors: El-Matary Wael , Carroll Matthew W , Deslandres Colette , Griffiths Anne M , Kuenzig M Ellen , Mack David R , Wine Eytan , Weinstein Jake , Geist Rose , Davis Tal , Chan Justin , Khan Rabia , Matthews Priscilla , Kaplan Gilaad G , Windsor Joseph W , Bernstein Charles N , Bitton Alain , Coward Stephanie , Jones Jennifer L , Lee Kate , Murthy Sanjay K , Targownik Laura E , Peña-Sánchez Juan-Nicolás , Rohatinsky Noelle , Ghandeharian Sara , Im James H B , Goddard Quinn , Gorospe Julia , Verdugo Jules , Morin Samantha A , Morganstein Taylor , Banning Lisa , Benchimol Eric I 
Published: September 2023

Abstract
Rates of inflammatory bowel disease (IBD) in Canadian children and adolescents are among the highest in the world, and the incidence is rising most rapidly in children under five years of age. These young children may have either a typical form of IBD with multi-factorial aetiology, or they may have a monogenic form. Despite the growing number of children in Canada living with this important chronic disease, there are few available medical therapies approved by Health Canada due to the omission of children from most clinical trials of newly developed biologics. As a result, off-label use of medications is common, and physicians have learned to use existing therapies more effectively. In addition, most Canadian children are treated in multidisciplinary, specialty clinics by physicians with extra training or experience in IBD, as well as specialist nurses, dietitians, mental health care providers and other allied health professionals. This specialized clinic approach has facilitated cutting edge research, led by Canadian clinicians and scientists, to understand the causes of IBD, the optimal use of therapies, and the best ways to treat children from a biopsychosocial perspective. Canadians are engaged in work to understand the monogenic causes of IBD; the interaction between genes, the environment, and the microbiome; and how to address the mental health concerns and medical needs of adolescents and young adults transitioning from paediatric to adult care.
A feasibility study on time-lapse controlled-source electromagnetic method for hydraulic fracturing monitoring of Well Eyangye-2HF in Yichang, Hubei Province, China
Authors: Sun Qilong , Tan Handong , Zhang Yunxiao , Wan Wei , Peng Rong , Luo Weifeng 
Published: September 2023

Abstract
Hydraulic fracturing plays a crucial role in enhancing reserves and production of unconventional oil and gas resources. Injecting fracturing fluids into the ground to improve reservoirs also introduces the risk of inducing earthquakes; thus, monitoring the migration of these fluids is crucial. The microseismic positioning method determines the fracturing fluid by locating microseismic events generated by the fractured rock strata; however, this method is susceptible to errors. Low-resistivity subsurface fluids can directly change electromagnetic field signals, making the electromagnetic method a technically advantageous approach for monitoring the migration of hydraulic fracturing fluids. The monitoring test data of Well Eyangye-2HF show that the time-lapse controlled-source electromagnetic (CSEM) method is suitable for hydraulic fracturing and has good monitoring effects. The results of CSEM method can also compensate for deficiencies in microseismic monitoring. The electric field (Ex) observed using the CSEM method can directly predict the distribution edge of the fracturing fluid, and the anomalous zone of the Exrate of change is consistent with the fracturing-fluid injection parameters and microseismic monitoring results. The analysis of field data and forward simulation, based on electrical logging results, led to the conclusion that hydraulic fracturing operations can cause changes in the resistivity of the target layer and surrounding strata. These changes are attributed to the synergistic effects of formation stress, temperature, and the fracturing fluid. The electric-field changes observed using the CSEM method may be caused by multiple factors; however, use of time-lapse CSEM for monitoring hydraulic fracturing is still feasible.
‘The whitest guy in the room’: thoughts on decolonization and paideia in the South African university
Authors: Griffiths Dominic 
Published: September 2023

ABSTRACT
This paper will reflect on the possibility of epistemic decolonization, particularly in terms of curriculum, as a transformative educational process in the context of the South African university, and with respect to my own positionality. The argument will centre around two difficult interdependent positions. On the one hand I will argue for the university’s task as transformational, even offering, via Cornel West, the ‘salvific’ possibility that knowledge offers those who seek it. To develop this claim, I will draw on and develop the notion of paideia though the work of Plato and Heidegger.
On the other hand, within the postcolonial African university, the question of decolonization in the tertiary space cannot be elided, particularly since the 2015 #RhodesMustFall and #FeesMustFall movements. The university is a powerful colonial relic, and it can be used to reinforce and perpetuate epistemic violence through unreflective or unconscious pedagogical and curriculum decisions. Here I draw on decolonial thinkers such as Santos, Mignolo, Maldonado-Torres, and Mbembe: I argue for a reckoning with the forces of coloniality, and advocate for epistemic justice and criticality, as part of the decolonizing project. In conclusion, working with ideas from Cornel West, I argue to reconcile paideia, as the ‘turning of the soul’, with the decolonizing African university.
A dynamic social relations model for clustered longitudinal dyadic data with continuous or ordinal responses
Authors: Pillinger Rebecca , Steele Fiona , Leckie George , Jenkins Jennifer 
Published: September 2023

Abstract
Social relations models allow the identification of cluster, actor, partner, and relationship effects when analysing clustered dyadic data on interactions between individuals or other units of analysis. We propose an extension of this model which handles longitudinal data and incorporates dynamic structure, where the response may be continuous, binary, or ordinal. This allows the disentangling of the relationship effects from temporal fluctuation and measurement error and the investigation of whether individuals respond to their partner’s behaviour at the previous observation. We motivate and illustrate the model with an application to Canadian data on pairs of individuals within families observed working together on a conflict discussion task.
Wheat cis-zeatin-O-glucosyltransferase cZOGT1 interacts with the Ca2+-dependent lipid binding protein TaZIP to regulate senescence
Authors: Wang Wenqiang , Zhang Gaungqiang , Wang Wenlong , Wang Zhigang , Lv Yuelin , Guo Fenxia , Di Yindi , Zhang Jifa , Wang Yuhai , Wang Wei , Li Yuanyuan , Hao Qunqun 
Published: September 2023

Abstract
Premature senescence is an important factor affecting wheat yield and quality. Wheat yield can be increased by delaying senescence and prolonging the effective photosynthetic time. Previously, we found that the cis-zeatin-O-glucosyltransferase (cZOGT1) gene plays an important role in the stay-green wheat phenotype. In this study, cZOGT1-overexpressing lines exhibited a delayed senescence phenotype, despite a significant reduction in the total cytokinin content. Further, we found that cZOGT1 interacted with the Ca2+-dependent lipid binding protein TaZIP (cZOGT1-interacting protein), and that a high level of cZOGT1 expression led to the suppression of TaZIP expression, which in turn, reduced abscisic acid (ABA) content. The synergistic reduction in cytokinins and ABA levels eventually caused the stay-green phenotype in cZOGT1-overexpressing lines. This study provides a new theoretical basis to explain the mechanism underlying the wheat stay-green phenotype and provides a genetic resource for wheat molecular-design breeding.
Reactive oxygen species- and nitric oxide-dependent regulation of ion and metal homeostasis in plants
Authors: Sandalio Luisa M , Espinosa Jesús , Shabala Sergey , León José , Romero-Puertas María C 
Published: September 2023

Abstract
Deterioration and impoverishment of soil, caused by environmental pollution and climate change, result in reduced crop productivity. To adapt to hostile soils, plants have developed a complex network of factors involved in stress sensing, signal transduction, and adaptive responses. The chemical properties of reactive oxygen species (ROS) and reactive nitrogen species (RNS) allow them to participate in integrating the perception of external signals by fine-tuning protein redox regulation and signal transduction, triggering specific gene expression. Here, we update and summarize progress in understanding the mechanistic basis of ROS and RNS production at the subcellular level in plants and their role in the regulation of ion channels/transporters at both transcriptional and post-translational levels. We have also carried out an in silico analysis of different redox-dependent modifications of ion channels/transporters and identified cysteine and tyrosine targets of nitric oxide in metal transporters. Further, we summarize possible ROS- and RNS-dependent sensors involved in metal stress sensing, such as kinases and phosphatases, as well as some ROS/RNS-regulated transcription factors that could be involved in metal homeostasis. Understanding ROS- and RNS-dependent signaling events is crucial to designing new strategies to fortify crops and improve plant tolerance of nutritional imbalance and metal toxicity.
Secular outflows from 3D MHD hypermassive neutron star accretion disc systems
Authors: Fahlman Steven , Fernández Rodrigo , Morsink Sharon 
Published: September 2023

ABSTRACT
Magnetized hypermassive neutron stars (HMNSs) have been proposed as a way for neutron star mergers to produce high electron fraction, high-velocity ejecta, as required by kilonova models to explain the observed light curve of GW170817. The HMNS drives outflows through neutrino energy deposition and mechanical oscillations, and raises the electron fraction of outflows through neutrino interactions before collapsing to a black hole (BH). Here, we perform 3D numerical simulations of HMNS–torus systems in ideal magnetohydrodynamics, using a leakage/absorption scheme for neutrino transport, the nuclear APR equation of state, and Newtonian self-gravity, with a pseudo-Newtonian potential added after BH formation. Due to the uncertainty in the HMNS collapse time, we choose two different parametrized times to induce collapse. We also explore two initial magnetic field geometries in the torus, and evolve the systems until the outflows diminish significantly ($\sim\!\! 1\!\! - \!\!2\ \mathrm{s}$). We find bluer, faster outflows as compared to equivalent BH–torus systems, producing M ∼ 10−3 M⊙ of ejecta with Ye ≥ 0.25 and v ≥ 0.25c by the simulation end. Approximately half the outflows are launched in disc winds at times $t\lesssim 500 \ \mathrm{ms}$, with a broad distribution of electron fractions and velocities, depending on the initial condition. The remaining outflows are thermally driven, characterized by lower velocities and electron fractions. Nucleosynthesis with tracer particles shows patterns resembling solar abundances in all models. Although outflows from our simulations do not match those inferred from two-component modelling of the GW170817 kilonova, self-consistent multidimensional detailed kilonova models are required to determine whether our outflows can power the blue kilonova.
Microorganisms and dissolved metabolites distinguish Florida's Coral Reef habitats
Authors: Becker Cynthia C , Weber Laura , Zgliczynski Brian , Sullivan Chris , Sandin Stuart , Muller Erinn , Clark Abigail S , Kido Soule Melissa C , Longnecker Krista , Kujawinski Elizabeth B , Apprill Amy 
Published: September 2023

Abstract
As coral reef ecosystems experience unprecedented change, effective monitoring of reef features supports management, conservation, and intervention efforts. Omic techniques show promise in quantifying key components of reef ecosystems including dissolved metabolites and microorganisms that may serve as invisible sensors for reef ecosystem dynamics. Dissolved metabolites are released by reef organisms and transferred among microorganisms, acting as chemical currencies and contributing to nutrient cycling and signaling on reefs. Here, we applied four omic techniques (taxonomic microbiome via amplicon sequencing, functional microbiome via shotgun metagenomics, targeted metabolomics, and untargeted metabolomics) to waters overlying Florida's Coral Reef, as well as microbiome profiling on individual coral colonies from these reefs to understand how microbes and dissolved metabolites reflect biogeographical, benthic, and nutrient properties of this 500-km barrier reef. We show that the microbial and metabolite omic approaches each differentiated reef habitats based on geographic zone. Further, seawater microbiome profiling and targeted metabolomics were significantly related to more reef habitat characteristics, such as amount of hard and soft coral, compared to metagenomic sequencing and untargeted metabolomics. Across five coral species, microbiomes were also significantly related to reef zone, followed by species and disease status, suggesting that the geographic water circulation patterns in Florida also impact the microbiomes of reef builders. A combination of differential abundance and indicator species analyses revealed metabolite and microbial signatures of specific reef zones, which demonstrates the utility of these techniques to provide new insights into reef microbial and metabolite features that reflect broader ecosystem processes.
Enhanced vibrational stability in glass droplets
Authors: Chakraborty Surajit , Krishnan Vishnu V , Ramola Kabir , Karmakar Smarajit 
Published: September 2023

Abstract
We show through simulations of amorphous solids prepared in open-boundary conditions that they possess significantly fewer low-frequency vibrational modes compared to their periodic boundary counterparts. Specifically, using measurements of the vibrational density of states, we find that the D(ω)∼ω4 law changes to D(ω)∼ωδ with δ≈5 in two dimensions and δ≈4.5 in three dimensions. Crucially, this enhanced stability is achieved when utilizing slow annealing protocols to generate solid configurations. We perform an anharmonic analysis of the minima corresponding to the lowest frequency modes in such open-boundary systems and discuss their correlation with the density of states. A study of various system sizes further reveals that small systems display a higher degree of localization in vibrations. Lastly, we confine open-boundary solids in order to introduce macroscopic stresses in the system, which are absent in the unconfined system and find that the D(ω)∼ω4 behavior is recovered.
Negative Nominal Interest Rates and the Bank Lending Channel
Authors: Eggertsson Gauti B , Juelsrud Ragnar E , Summers Lawrence H , Wold Ella Getz 
Published: September 2023

Abstract
We investigate the bank lending channel of negative nominal policy rates from an empirical and theoretical perspective. For the empirical results, we rely on Swedish data, including daily bank-level lending rates. We find that retail household deposit rates are subject to a lower bound (DLB). Empirically, once the DLB is met, the pass-through to mortgage lending rates and credit volumes is substantially lower and bank equity values decline in response to further policy rate cuts. We construct a banking sector model and use our estimate of the pass-through of negative policy rates to lending rates as an identified moment to parameterize the model and assess the impact of negative policy rates in general equilibrium. Using the theoretical framework, we derive a sufficient statistic for when negative policy rates are expansionary and when they are not.
Hydraulic segmentation explains differences in loss of branch conductance caused by fire
Authors: West Adam G , Bloy Shonese T , Skelton Robert P , Midgley Jeremy J 
Published: September 2023

Abstract
The hydraulic death hypothesis suggests that fires kill trees by damaging the plant’s hydraulic continuum in addition to stem cambium. A corollary to this hypothesis is that plants that survive fires possess ‘pyrohydraulic’ traits that prevent heat-induced embolism formation in the xylem and aid post-fire survival. We examine whether hydraulic segmentation within stem xylem may act as such a trait. To do so, we measured the percentage loss of conductance (PLC) and vulnerability to embolism axially along segments of branches exposed to heat plumes in two differing species, fire-tolerant Eucalyptus cladocalyx F. Muell and fire-sensitive Kiggelaria africana L., testing model predictions that fire-tolerant species would exhibit higher degrees of hydraulic segmentation (greater PLC in the distal parts of the branch than the basal) than fire-intolerant species (similar PLC between segments). Following exposure to a heat plume, K. africana suffered between 73 and 84% loss of conductance in all branch segments, whereas E. cladocalyx had 73% loss of conductance in whole branches, including the distal tips, falling to 29% in the most basal part of the branch. There was no evidence for differences in resistance segmentation between the species, and there was limited evidence for differences in distal vulnerability to embolism across the branches. Hydraulic segmentation in E. cladocalyx may enable it to resprout effectively post-fire with a functional hydraulic system. The lack of hydraulic segmentation in K. africana reveals the need to understand possible trade-offs associated with hydraulic segmentation in long-lived woody species with respect to drought and fire.