bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigation of miR-15b-5p expression and role in head and neck squamous cell carcinoma based on meta-analysis and bioinformatics analysis
Authors: Su Xuejin , Zhou Ziyan , Chen Weimin , Zhu Mingjing , Wu Lanhua , Yin Yuanxiu , Chen Sixia , Kang Min 
Published: August 2023

Abstract
Background: In the current study, miR-15b-5p expression and role in HNSCC remains indistinct. The aim of this study was to investigate the expression and role of miR-15b-5p in HNSCC.
Methods: The data obtained from Gene Expression Omnibus (GEO) and the Cancer Genome Atlas (TCGA) databases was used to estimate the expression and diagnostic value of miR-15b-5p in HNSCC by meta-analysis and diagnostic test. We determined miR-15b-5p expression in HNSCC using RT-qPCR and predicted its key genes using miRWalk and GEPIA2 databases. Enrichment analyses were used to investigate the effects and signaling pathways associated with miR-15b-5p in HNSCC. The effect of target genes on disease-free survival (DFS) and overall survival (OS) in patients were assessed using Kaplan-Meier survival analysis.
Results: The result of meta-analysis and RT-qPCR indicated that miR-15b-5p was overexpressed in HNSCC (P<0.05). Diagnostic test demonstrated that the pooled sensitivity, specificity, PLR, NLR, and DOR values were as follows: 0.70 (95% CI:0.67-0.73), 0.72 (95% CI: 0.67-0.77), 2.15 (95% CI: 1.57-2.94), 0.48 (95% CI: 0.35-0.67), and 7.33 (95% CI: 4.95-10.86), respectively. Based on the SROC curve analysis, the AUC was 0.81 (95% CI: 0.77-0.84), indicating that miR-15b-5p played a potential diagnostic role in identifying HNSCC tissues. MiR-15b-5p expression were higher in N1- 4 stages than in N0 stage, and in T3- 4 stages than in T1-2 stages (P < 0.05). Enrichment analysis showed that miR-15b-5p may participate in HNSCC by regulating the retinol metabolism pathway. RDH12 and UGT1A7 were downregulated in HNSCC, with the Spearman’s analysis demonstrating that RDH12 expression was inversely proportional to miR-15b-5p, whereas UGT1A7 expression was directly proportional to miR-15b-5p (P<0.05). The methylation levels of UGT1A10 and UGT1A7 in HNSCC were appreciably lower than those in the control, and the DFS of patients with high UGT1A7 expression were significantly longer than those with low expression (P<0.05). High UGT1A7 expression is a favorable factor for good DFS in patients with HNSCC.
Conclusion: MiR-15b-5p may regulate the retinol metabolism pathway by targeting UGT1A7, thereby affecting HNSCC prognosis. MiR-15b-5p may be a novel biomarker to predict the disease progression and prognosis in patients with HNSCC.
A Secure and Interoperable Architecture for Blockchain/IPFS Assisted Electronic Health Record Access Control and Sharing
Authors: Kenaza Tayeb , Messai Sami , Debicha Islam , Sehaki Mehdi 
Published: August 2023

Abstract
Electronic Health Records (EHRs) store sensitive and critical patient information, necessitating stringent access control and sharing mechanisms to uphold data security and comply with privacy regulations such as the General Data Protection Regulation (GDPR). In this paper, we propose a comprehensive architecture and a suite of efficient protocols that leverage the synergistic capabilities of blockchain and Interplanetary File System (IPFS) technologies to enable secure access control and sharing of EHRs. Our approach is based on a private blockchain, wherein smart contracts are deployed to enforce control exclusively by patients. By granting patients exclusive control over their EHRs, our solution ensures compliance with personal data protection laws and empowers individuals to manage their health information autonomously. Notably, our proposed architecture seamlessly integrates with existing health provider information systems, facilitating interoperability and effectively addressing security and data heterogeneity challenges. To exhibit the effectiveness of our approach, we developed a prototype implementation utilizing the Ethereum platform, enabling the simulation of diverse scenarios involving access control and health data sharing among healthcare practitioners. Our experimental results demonstrate the scalability, recovery mechanisms, and revocation procedures embedded within our solution, thereby substantiating its efficacy and robustness in real-world healthcare settings. Overall, our study provides a significant contribution towards a secure and interoperable framework for EHR access control and sharing, leveraging patient-centric control mechanisms.
Assistive technology’s potential to improve employment of people with disabilities
Authors: Kruse Douglas , Schur Lisa , Johnson-Marcus Hazel-Anne , Gilbert Lauren , Lallo Antonio Di , Gao Weibo , Su Hao 
Published: August 2023

Abstract
Purpose:
This study investigates how access to assistive technologies affects employment and earnings among people with disabilities
Methods:
We first document employment and earnings gaps associated with specific disabilities using 2017-2021 American Community Survey and 2014 Survey of Income and Program Participation data. We then use accommodations data from the 2012, 2019, and 2021 Current Population Survey (CPS) Disability Supplements to examine employment and earnings growth for people with disabilities related both to any, and to technology-based, accommodations. We also provide a case example of a specific new assistive technology: a “wearable robot” that assists people with upper body impairments.
Results:
Almost all disability types are linked to lower employment and earnings, with especially low employment among those with mobility impairments and particularly low earnings among those with cognitive impairments. About one-tenth of workers with disabilities received any accommodations, and 3-4% received equipment-based accommodations in the 2012-2021 period; these figures increased slightly over the period. The occupations with the highest disability accommodations rates had greater disability employment growth from 2012 to 2021, but disability pay gaps did not decrease more in these occupations. The exoskeleton in our case example can address the estimated employment deficits associated with lifting, reaching, grasping, and pushing/pulling for people with upper body impairments.
Conclusion:
Assistive technology accommodations have potential for increasing employment opportunities for people with disabilities.
Near-global Summer Circulation Response to the Spring Surface Temperature Anomaly in Tibetan Plateau ---- The GEWEX/LS4P Phase I experiment
Authors: Zhang Yang , Pan Yan , Xue Yongkang , Diallo Ismaila , Zeng Xubin , Li Shuting , Neelin J. David , Lau William K.M , Boone Aaron A. , Vitart Frederic , Yao Tandong , Tang Qi , Sato Tomonori , Koo Myung-Seo , Ardilouze Constantin , Saha Subodh K. , Yang Jing , Materia Stefano , lin Zhaohui , Qi Xin , Qin Yi , Nakamura Tetsu , Nobre Paulo , Peano Daniele , Senan Retish , Takaya Yuhei , Wang Hailan , Zhang Hongliang , Zhan Yanling , Zhao Mei , Mechoso Carlos R. , Bao Qing , Bottino Marcus Jorge , Hong Songyou , Lin Yanluan , Xie Shaocheng , Pan Xiaoduo , Nayak Hara Prasad , Chou Sin Chan , Guo Weidong 
Published: August 2023

Abstract
Subseasonal to seasonal (S2S) prediction of droughts and floods is one of the major challenges of weather and climate prediction. Recent studies suggest that the springtime land surface temperature/subsurface temperature (LST/SUBT) over the Tibetan Plateau (TP) can be a new source of S2S predictability. The project “Impact of Initialized Land Surface Temperature and Snowpack on Subseasonal to Seasonal Prediction (LS4P)” was initiated to study the impact of springtime LST/SUBT anomalies over high mountain areas on summertime precipitation predictions.
The present work explores the simulated global scale response of the atmospheric circulation to the springtime TP land surface cooling by 16 current state-of-the-art Earth System Models (ESMs) participating in the LS4P Phase I (LS4P-I) experiment. The LS4P-I results show, for the first time, that springtime TP surface anomalies can modulate a persistent quasi-barotropic Tibetan Plateau-Rocky Mountain Circumglobal (TRC) wave train from the TP via the northeast Asia and Bering Strait to the western part of the North America, along with the springtime westerly jet from TP across the whole North Pacific basin. The TRC wave train modulated by the TP thermal anomaly play a critical role on the early summer surface air temperature and precipitation anomalies in the regions along the wave train, especially over the northwest North America and the southern Great Plains. The participant models that fail in capturing the TRC wave train greatly under-predict climate anomalies in reference to observations and the successful models. These results suggest that the TP LST/SUBT anomaly via the TRC wave train is the first order source of the S2S variability in the regions mentioned. Furthermore, the TP surface temperature anomaly can influence the Southern Hemispheric circulation by generating cross-equator wave trains. However, the simulated propagation pathways from the TP into the Southern Hemisphere show large inter-model differences. More dynamical understanding of the TRC wave train as well as its cross-equator propagation into the Southern Hemisphere will be explored in the newly launched LS4P phase II experiment.
Comparing Apples and Oranges? The Influence of Java Profiler Choice on the Identification of Hot Methods for Genetic Improvement
Authors: Watkinson Myles , Brownlee Alexander Edward Ian 
Published: August 2023

Abstract
Genetic improvement (GI) of software applies search-based optimisation to existing software and many existing pieces of work show its successful application in a variety of contexts. GI generates variants of the original program, testing each for functionality and properties such as run time or memory footprint. A common approach to increase the efficiency of the GI search is to profile the target application to identify hot methods that the code variations are focused on. More widely, of course, profiling is an important tool in the software developer's box. We recently upgraded the profiler included in the GI toolbox Gin from HPROF (Java 8) to Java Flight Recorder (JFR) (Java 9+). In doing so, we explored whether the change of profiler would have much impact on the profiling results: specifically the hot methods identified for a target application. We now expand that work with a much wider experimental study comparing HPROF on Java 8, and JFR on Java 9 and 17, within Gin on six target open-source applications, for both run time and memory use. We find that a small number of repeat runs (20) of any one profiler is enough to produce remarkably consistent results. Perhaps unsuprisingly, changing the profiler and JDK dramatically change the hot methods identified. We also show that localising test suites during the profiling process is unwise, often missing relevant members of the test suite.
Dual Optimization For Enhancing TRA in MCF-based SDM-EONs
Authors: Petale Shrinivas , Subramaniam Suresh 
Published: August 2023

Abstract
A fine-grained, flexible frequency grid of elastic optical transmission and space division multiplexing (SDM) in conjunction with spectrally efficient modulations is an ideal solution for the impending capacity crunch. The routing, modulation, core, and spectrum assignment (RMCSA) problem is an important lightpath resource assignment problem in SDM elastic optical networks (SDM-EONs). Intercore Crosstalk (XT) degrades the quality of parallel transmissions on adjacent cores, and the RMCSA algorithm must satisfy XT requirements while optimizing network performance. There is an indirect tradeoff between spectrum utilization and XT tolerance; while higher modulations are more spectrum-efficient, they are also less tolerant of XT because they allow fewer connections between neighbouring cores on the overlapping spectrum. In the presence of XT, the Tridental Resource Assignment algorithm (TRA) has been shown to optimally assign resources in multicore fiber networks. Using the tridental coefficient (TC), this algorithm strikes a balance between spectrum utilization and XT. However, TRA is computationally expensive because TC is calculated for all the possible candidate resource sets for each lightpath request. In this paper, we demonstrate that acceptable or better TRA performance can be achieved while reducing computational overhead than traditional TRA. We achieve that using different stages of offline optimization, required only once. We demonstrate that by using tailored weights in TC, the performance of TRA can be enhanced further. We observe that acceptable TRA performance can be achieved with as low as 40% of the total computations and that adjusting weights reduces the bandwidth blocking of TRA, which is already performing better than the baseline algorithms, by approximately two orders of magnitude.
Analyzing the role of consumer behavior in coping with intermittent supply in water distribution systems
Authors: Abhijith Gopinathan R. , Naidu Maddukuri Naveen , Boindala Sriman Pankaj , Vasan A , Ostfeld Avi 
Published: August 2023

Abstract

A substantial number of water distribution systems (WDS) worldwide are operated as intermittent water supply (IWS) systems, delivering water to consumers in irregular and unreliable manners. The IWS consumers commonly adapt to flexible consumption behaviors characterized by storing the limited water available during shorter supply periods in intermediate storage facilities for subsequent usage during more extended nonsupply periods. Nevertheless, the impacts of such consumer behavior on the performance of IWS systems have not been adequately addressed. Toward this direction, this article presents a novel open-source Python-based simulation tool (EPyT-IWS) for WDS, virtually acting like an IWS modeling extension of EPANET 2.2. The applicability of EPyT-IWS was demonstrated by conducting hydraulic simulations of a typical WDS with representative IWS attributes. Different IWS operation cases were considered by varying the amount and consistency of the water availability to the consumers. EPyT-IWS outputs showed that domestic storage of water within underground tanks and subsequent pumping into overhead tanks allows consumers to cope with the intermittent water availability and suitably meet their demands. Besides the interval, the clock time of the water supply was predicted to influence IWS consumers’ ability to meet water demands.
Flash drought as a new climate threat: drought indices, insights from a study in India and implications for future research
Authors: Rakkasagi Shivukumar , Poonia Vikas , Goyal Manish Kumar 
Published: August 2023

Abstract

A flash drought (FD) event is a relatively new form of severe occurrence, described by the quick onset and intensification of drought situations with serious consequences. This paper aims to understand the wide variety of studies and serve as a basis for future research potentials of FDs. An effort has been made to understand the advantages and limitations of the existing indices used for FD identification. A study in India was carried out for the identification of FDs using daily gridded data of soil moisture for eight days (octad). The results reveal that the Indus basin faced around 82% and the Cauvery basin faced about 88% of severe FDs during the monsoon and non-monsoon seasons, respectively. Additionally, the results show that the Indus basin faces FD in the monsoon season since the basin has mostly barren areas and wasteland. This review also highlights the role of humidity, wind and radiation, soil characteristics, climate oscillations, and the relation between FDs and heavy-rainfall-induced flash floods. Furthermore, the paper has depicted some specific research-needs to monitor, forecast, plan, and respond with crucial points.
Multi-scale flow regimes and driving forces analysis based on different models: a case study of the Wu River basin
Authors: Wang Hongxiang , Cheng Siyuan , He Ning , Huang Lintong , Yang Huan , Hong Fengtian , Ma Yinchu , Chen Wenxiong , Guo Wenxian 
Published: August 2023

Abstract

Quantitatively separating the influence of climate change and human activities on runoff is crucial to achieving sustainable water resource management in watersheds. This study presents a framework for quantitative assessment by integrating the indicators of hydrologic alteration, the whale optimization algorithm and random forest (WOA-RF), and the water erosion prediction (WEP-L) models. This framework quantifies the differences in hydrological conditions and their driving forces at multi-timescales (annual, seasonal, and monthly). The results indicate that the runoff of the Wu River has decreased since 2005. Climate factors were found to influence the interannual variation of runoff mainly. Meanwhile, human activities had a more significant impact in autumn, with a relative contribution rate of 59.0% (WOA-RF model) and 70.8% (WEP-L model). Monthly, the picture is more complex, with the results of the WOA-RF model indicating that climate change has a significant impact in July, August, and September (88.8%, 92.7%, and 79.3%, respectively). However, the WEP-L model results showed that the relative contribution of land use is significant in April, May, June, October, and November (51.24%, 64.23%, 63.63%, 53.16%, and 50.63%, respectively). The results of the study can be helpful for regional water allocation.
Use of Albumin for Drug Delivery as a Diagnostic and Therapeutic Tool
Authors: Karami Elmira , Mesbahi Moghaddam Maryam , Kazemi-Lomedasht Fatemeh 
Published: August 2023

Abstract:
Drug delivery is an important topic that has attracted the attention of researchers in
recent years. Albumin nanoparticles play a significant role in drug delivery as a carrier due to their
unique characteristics. Albumin is non-toxic, biocompatible, and biodegradable. Its structure is
such that it can interact with different drugs, which makes the treatment of the disease faster and
also reduces the side effects of the drug. Albumin nanoparticles can be used in the diagnosis and
treatment of many diseases, including cancer, diabetes, Alzheimer's, etc. These nanoparticles can
connect to some compounds, such as metal nanoparticles, antibodies, folate, etc. and create a powerful
nanostructure for drug delivery. In this paper, we aim to investigate albumin nanoparticles in
carrier format for drug delivery application. In the beginning, different types of albumin and their
preparation methods were discussed, and then albumin nanoparticles were discussed in detail in
diagnosing and treating various diseases.
Bibliometric Analysis of the Research Status and Global Trends in
Behavioral and Psychological Symptoms of Dementia in Alzheimer’s
Disease from 2002 to 2022
Authors: Cai Haipeng , Du Ruonan , Yang Kebing , Li Wei , Wang Zhiren 
Published: August 2023

Background:
Several reviews on behavioral and psychological symptoms (BPSDs) in patients
with Alzheimer’s disease (AD) have summarized the current state of this field, but global trends
are unclear.

Objective:
This study utilized CiteSpace to provide a global overview of the current state of research
on AD and its BPSDs and to predict future research trends in the field.

Methods:
Data were retrieved from the Web of Science Core Collection. Bibliometric and cooccurrence
analyses were performed using CiteSpace software. In total, 787 valid publications were
included in the analysis.

Results:
Publications on AD and BPSD have shown an increasing trend since 2002. The United States
and the University of Toronto were the countries and institutions with the highest total number of publications,
respectively. Japan and China were the second and third most influential in the field. Clive
Ballard was the top author in terms of the number of publications. Journal of Alzheimer's Disease had
the highest number of publications on this topic. Co-occurrence analysis showed that AD, behavioral
symptoms, cognitive impairment, and early markers are hot topics in this area. Non-drug management
of BPSDs, pharmacological treatment, and physiotherapy will be a hot topic in this field in the future.

Conclusion:
Our study visualized the relevant articles over the past 21 years to detect global hotspots
and trends. Our findings may help researchers to identify research hotspots in this field and will help
in the selection of appropriate research topics, while possibly leading to cross-regional cooperation.
Probiotic Influences on Motor Skills: A Review
Authors: Lalonde Robert , Strazielle Catherine 
Published: August 2023

Abstract:
The effects of probiotics have mostly been shown to be favorable on measures of anxiety
and stress. More recent experiments indicate single- and multi-strain probiotics in treating motorrelated
diseases. Initial studies in patients with Parkinson’s disease and Prader-Willi syndrome are
concordant with this hypothesis. In addition, probiotics improved motor coordination in normal animals
and models of Parkinson’s disease, multiple sclerosis, and spinal cord injury as well as grip
strength in hepatic encephalopathy. Further studies should delineate the most optimal bacterial profile
under each condition.
Solubility, the Main Concern for Poorly Water-soluble Drugs: Techniques and Alternatives
Authors: Singh Komal , Singh Preet Amol , Frank Amanda , Arora Saahil , Sharma Rajiv , Bajwa Neha 
Published: August 2023

:
The most important variable that affects a drug's bioavailability is its aqueous solubility. One of the biggest issues facing the pharmaceutical business is improving water solubility, which is the key to improving therapeutic efficacy. During the first screening procedure, over 50% of recently created medications are discovered to be insoluble or weakly soluble. The solubility of the medicine can be increased using a variety of techniques. The method entails both chemical and physical drug modifications. Any medicine that is absorbed must be present at the absorption site in the form of a solution. Poorly soluble medications can be made more soluble using a variety of approaches, like physical and chemical alterations to the drug and other strategies. Using a surfactant, complexation, and so on are examples of solid dispersion. The choice of a solubility-improving technology is influenced by pharmacological properties, absorption sites, and the requirements for the dosage form. In order to serve as a quick reference, this study attempted to gather information on various solubility improvement methods and organize it systematically.