bluuebunny/crossref_metadata_2025_split huggingface dataset:
Taxonomy and paleobiogeography of rudist bivalves from Upper Cretaceous strata, Gulf Coastal Plain and Puerto Rico, USA
Authors: Zimmerman Alexander N. , Johnson Claudia C. , Phillips George E. , Ehret Dana J. 
Published: January 2023

AbstractThis study provides the first focused investigation of rudist bivalves from the Upper Cretaceous of the Gulf Coastal Plain (GCP) in the southern US and previously undescribed specimens from the Flor de Alba Limestone Member of the Pozas Formation in Puerto Rico. Identified rudists from the GCP comprise the Monopleuridae, includingGyropleura, as well as Radiolitidae, includingBiradiolites cardenasensi,Durania maxima,Guanacastea jamaicensis,Radiolites acutocostata, andSauvagesia. Integrating rudist occurrences within well-established GCP biostratigraphy allows for extension of upper ranges ofD.maximaandR.acutocostatainto the late Campanian, and extension of the lower ranges ofB.cardenasensisandG.jamaicensisinto the early Campanian. Identified rudists from Puerto Rico comprise the Hippuritidae and includeBarrettia monilifera, which supports the age of the Flor de Alba Limestone Member of the Pozas Formation as middle Campanian. Combined taxonomic, biostratigraphic, and paleobiogeographic analyses indicate there is no rudist fauna endemic to the GCP, and the region marks the northeastern range of the Caribbean generaBiradiolites,Durania,Guanacastea,Gyropleura,Radiolites,andSauvagesiaduring the Campanian and Maastrichtian. The new occurrences help inform future updates of Late Cretaceous sea surface-current reconstructions for the Caribbean and Western Interior Seaway, USA.
Spatial heterogeneity in benthic foraminiferal assemblages tracks regional impacts of paleoenvironmental change across Cretaceous OAE2
Authors: Bryant Raquel , Belanger Christina L. 
Published: January 2023

AbstractThe impact of global climate events on local ecosystems can vary spatially. Understanding this potential heterogeneity can illuminate which environments will be most impacted and the proximal drivers of ecosystem responses. Cenomanian–Turonian marine deposits of the Western Interior Seaway (WIS) record paleoceanographic changes associated with the Greenhorn transgression and the onset of Oceanic Anoxic Event 2 (OAE2). They provide an ideal setting to study basin-wide paleoecological responses during a global perturbation. Here, we integrate benthic foraminiferal assemblages from before, during, and after OAE2 via multivariate ordination analysis to examine spatial patterns in faunal responses across the western United States on a common scale and to interrogate a previously defined faunal marker commonly used for basin-wide correlation, the Benthonic Zone (BZ). We identify oxygenation and organic matter quality as primary and secondary controls of faunal variation across the 10 stratigraphic records and use this variation to infer paleoenvironmental changes. Stratigraphic trends reveal, in contrast to previous studies, deoxygenation at the onset of OAE2. They also reveal temporal patterns in oxygenation and productivity consistent with the gradual northward migration of a southern water mass into the WIS. This spatial heterogeneity hinders the use of the BZ as a temporal marker, because assemblages change in response to diachronous environmental change, and thus timing of the BZ with respect to OAE2 is not consistent across the basin. Our study demonstrates that regional processes can overshadow ecosystem responses to global events and underscores the importance of considering how changes in the position of water masses impact the expression of global biogeochemical perturbations.
Outcome-based contracting and gaming practices in marketised public employment services. Dilemmas from the Italian case
Authors: Scarano Gianluca 
Published: January 2023

AbstractConcerns about the unintended effects of marketised public employment services are increasingly expressed because there is mounting evidence that such services are frequently characterised by various gaming practices on the part of their providers. To prevent these unintended consequences, payment-by-result approaches have been progressively strengthened.The aim of the research reported in this article was to investigate the extent to which such approaches are able to make service providers accountable for client outcomes. The study used two Italian regional cases in order to compare different and alternative contracting arrangements: Lombardy (outcome-based payments), and Emilia-Romagna (fixed payments). Drawing on rich administrative databases, the analysis relied on a quantitative methodology based on propensity score matching and logistic regressions. Even if outcome-based contracting can make service providers financially accountable for the service outcome, the results of the analysis show that it does not sufficiently prevent gaming practices, resulting in inequity among the services provided.
A large A(H3N2) influenza outbreak with a high attack rate in a drug user community in Italy, April 2022
Authors: Gori Maria , Fappani Clara , Bianchi Silvia , Canuti Marta , Colzani Daniela , Ottogalli Paolo , Duehren Sarah , Tanzi Elisabetta , Amendola Antonella , Boschini Antonio 
Published: January 2023

Abstract
Despite the COVID-19 pandemic, influenza remains an important issue. Especially in community settings, influenza outbreaks can be difficult to control and can result in high attack rates. In April 2022, a large A(H3N2) influenza outbreak spread in the largest Italian drug-rehabilitation community. One hundred eighty-four individuals presented influenza-like symptoms (attack rate of 26.2%); 56% previously received the influenza vaccine. Sequence analyses highlighted a genetic drift from the vaccine strain, which may have caused the observed lack of protection.
Patient and parent-reported outcomes in paediatric ventricular assist device support: a multi-center ACTION learning network feasibility and pilot experience
Authors: Cousino Melissa K. , May Lindsay J. , Smyth Lauren , McQueen Melissa , Thompson Katherine , Hunter Tiffany , Ventresco Courtney , Fields Katrina , Murray Jenna , Machado Desiree S. , Shezad Muhammad , Zafar Farhan , Rosenthal David N. , Lorts Angela , Blume Elizabeth D. 
Published: January 2023

AbstractBackground:Patient- and proxy-reported outcomes (PROs) are an important indicator of healthcare quality and can be used to inform treatment. Despite the widescale use of PROs in adult cardiology, they are underutilised in paediatric cardiac care. This study describes a six-center feasibility and pilot experience implementing PROs in the paediatric and young adult ventricular assist device population.Methods:The Advanced Cardiac Therapies Improving Outcomes Network (ACTION) is a collaborative learning network comprised of 55 centres focused on improving clinical outcomes and the patient/family experience for children with heart failure and those supported by ventricular assist devices. The development of ACTION’s PRO programme via engagement with patient and parent stakeholders is described. Pilot feasibility, patient/parent and clinician feedback, and initial PRO findings of patients and families receiving paediatric ventricular assist support across six centres are detailed.Results:Thirty of the thirty-five eligible patients (85.7%) were enrolled in the PRO programme during the pilot study period. Clinicians and participating patients/parents reported positive experiences with the PRO pilot programme. The most common symptoms reported by patients/parents in the first month post-implant period included limitations in activities, dressing change distress, and post-operative pain. Poor sleep, dressing change distress, sadness, and fatigue were the most common symptoms endorsed >30 days post-implant. Parental sadness and worry were notable throughout the entirety of the post-implant experience.Conclusions:This multi-center ACTION learning network-based PRO programme demonstrated initial success in this six-center pilot study experience and yields important next steps for larger-scale PRO collection, research, and clinical intervention.
Evaluation of the accuracy of a six-degree-of-freedom robotic couch using optical surface and cone beam CT images of an SRS QA phantom
Authors: Zhang Q. , Chen Y. , Fang D. , Iannuzzi C. , Klein E. 
Published: January 2023

Abstract

Purpose:
To assess the accuracy of the Varian PerfectPitch six-degree-of-freedom (6DOF) robotic couch by using a Varian SRS QA phantom.

Methods:
The stereotactic radiosurgery (SRS) phantom has five tungsten carbide BBs each with 7·5 mm in diameter arranged with the known geometry. Optical surface images and cone beam CT (CBCT) images of the phantom were taken at different pitch, roll and rotation angles. The pitch, roll, and rotation angles were varied from −3 to 3 degrees by inputs from the linac console. A total of 39 Vision RT images with different rotation angle combinations were collected, and the Vision RT software was used to determine the rotation angles and translational shifts from those images. Eight CBCT images at most allowed rotational angles were analysed by in-house software. The software took the coordinates of the voxel of the maximum CT number inside a 7·5-mm sphere surrounding one BB to be the measured position of this BB. Expected BB positions at different rotation angles were determined by multiplying measured BB positions at zero pitch and roll values by a rotation matrix. Applying the rotation matrix to 5 BB positions yielded 15 equations. A linear least square method was used for regression analysis to approximate the solutions of those equations.

Results:
Of the eight calculations from CBCT images, the maximum rotation angle differences (degree) were 0·10 for pitch, 0·15 for roll and 0·09 for yaw. The maximum translation differences were 0·3 mm in the left–right direction, 0·5 mm in the anterior–posterior direction and 0·4 mm in the superior–inferior direction.

Conclusions:
The uncertainties of the 6-DOF couch were examined with the methods of optical surface imaging and CBCT imaging of the SRS QA phantom. The rotational errors were less than 0·2 degree, and the isocentre shifts were less than 0·8 mm.
Psychosocial well-being among patients with malignant pleural mesothelioma
Authors: Demirjian Caraline Craig , Saracino Rebecca M. , Napolitano Stephanie , Schofield Elizabeth , Walsh Leah E. , Key R. Garrett , Holland Jimmie 
Published: January 2023

AbstractObjectivesThe investigators conducted a psychosocial needs assessment of mesothelioma patients through self-report measures of quality of life (QOL), coping, depression, and social support.MethodsPatients with malignant pleural mesothelioma (MPM) (N = 67) completed a battery of assessments at a single timepoint after being approached during routine medical oncology clinic appointments or by letter.ResultsParticipants were predominately male (70.0%; n = 47) and ranged in age from 35 to 83 years old (M = 65.61, SD = 9.71). Most participants were white (88.0%; n = 59), and 10.0% (n = 7) were identified as Hispanic. The majority were married or living with a partner (93.0%; n = 62) and had some college or more education (64.0%; n = 43). Fourteen percent of participants (n = 11) endorsed significantly elevated depression symptoms. No significant demographic or clinical differences in depressed compared to nondepressed participants were observed, with a trend toward those identifying as Hispanic and those who were divorced as being more likely to be depressed. For the total sample, the most frequently endorsed coping strategies were active coping, emotional support, and acceptance.Significance of resultsThe present study did not identify any clear correlates of depression or QOL among patients with MPM. This research contributes to the small literature on psychosocial functioning in patients with MPM and provides putative directions for future larger studies and the development of interventions to provide appropriate support to diverse patients with MPM.
Prenatal dietary patterns in relation to adolescent offspring adiposity and adipokines in a Mexico City cohort
Authors: Fossee Erica , Zamora Astrid N. , Peterson Karen E. , Cantoral Alejandra , Perng Wei , Téllez-Rojo Martha M. , Torres-Olascoaga Libni A. , Jansen Erica C. 
Published: January 2023

AbstractMaternal diet during pregnancy has been associated with obesity among offspring. The extent to which trimester-specific dietary patterns are associated with markers of adiposity during adolescence remains unclear. We examined associations between prenatal diet patterns with adolescent offspring measures of adiposity and adipokines in 384 mother–adolescent dyads from the Mexico City ELEMENT cohort. Trimester-specific diet patterns were derived from principal component analysis of food frequency questionnaire data. Adolescent anthropometry and serum leptin and adiponectin were measured at 10–17 years. Three maternal diet patterns were identified: Prudent Diet (PD), high in fish and vegetables, the High Meat and Fat Diet (HMFD), high in pork and processed meats, and the Transitioning Mexican Diet (TMD), high in corn tortillas and sugar-sweetened beverages. Multiple linear regression was used to estimate sex-stratified associations among quartiles of diet patterns with adiposity and adipokines, adjusting for maternal marital status, education, and parity. First trimester TMD was associated with greater anthropometric measures and higher leptin in females, while third trimester HMFD was associated higher body fat percentage, triceps thickness, waist circumference, and leptin, but lower adiponectin among males. Contrary to expectation, there were positive associations between the trimester 1 PD pattern and anthropometric measurements in females, and for trimester 2 HMFD and TMD patterns with adipokines among males. Findings suggest maternal diet patterns may influence offspring adiposity markers during adolescence in a sex-specific manner.
Social Support in Online Peer Groups for Celiac	Disease
Authors: Köstlin Dorothee , Siem Birte , Rohmann Anette 
Published: January 2023

Abstract: Background: While there is considerable evidence for the positive effects of onsite peer support on health outcomes, few studies have addressed the impact of online peer support. Aims: This study differentiates between emotional (ES) and informational (IS) online peer support for people with celiac disease. We hypothesize that receiving ES and IS positively correlates with self-reported well-being and dietary compliance and that these relations would be moderated by the duration of illness. Method: We used a correlational, cross-sectional design ( N = 369). Results: Both functions of support were positively related to well-being and dietary compliance. The strengths of the positive relationships between ES and both outcomes and IS and well-being were independent of the duration of illness. IS was significantly positively related to dietary compliance among participants with a longer duration of illness, but unrelated among participants with a shorter duration. Limitations: Due to the correlational design, we cannot infer causality. Conclusion: Our findings advance the understanding of online support in contexts where proper self-management is crucial for health outcomes.
Climate Drivers of Malaria Transmission Seasonality and Their Relative Importance in Sub‐Saharan Africa
Authors: Yamba Edmund I. , Fink Andreas H. , Badu Kingsley , Asare Ernest O. , Tompkins Adrian M. , Amekudzi Leonard K. 
Published: January 2023

AbstractA new database of the Entomological Inoculation Rate (EIR) was used to directly link the risk of infectious mosquito bites to climate in Sub‐Saharan Africa. Applying a statistical mixed model framework to high‐quality monthly EIR measurements collected from field campaigns in Sub‐Saharan Africa, we analyzed the impact of rainfall and temperature seasonality on EIR seasonality and determined important climate drivers of malaria seasonality across varied climate settings in the region. We observed that seasonal malaria transmission was within a temperature window of 15°C–40°C and was sustained if average temperature was well above 15°C or below 40°C. Monthly maximum rainfall for seasonal malaria transmission did not exceed 600 in west Central Africa, and 400 mm in the Sahel, Guinea Savannah, and East Africa. Based on a multi‐regression model approach, rainfall and temperature seasonality were found to be significantly associated with malaria seasonality in all parts of Sub‐Saharan Africa except in west Central Africa. Topography was found to have significant influence on which climate variable is an important determinant of malaria seasonality in East Africa. Seasonal malaria transmission onset lags behind rainfall only at markedly seasonal rainfall areas such as Sahel and East Africa; elsewhere, malaria transmission is year‐round. High‐quality EIR measurements can usefully supplement established metrics for seasonal malaria. The study's outcome is important for the improvement and validation of weather‐driven dynamical mathematical malaria models that directly simulate EIR. Our results can contribute to the development of fit‐for‐purpose weather‐driven malaria models to support health decision‐making in the fight to control or eliminate malaria in Sub‐Saharan Africa.
Using the Shallow Strain Tensor to Characterize Deep Geologic Reservoirs
Authors: Murdoch Lawrence C. , DeWolf Scott , Germanovich Leonid N. , Moysey Stephen , Hanna Alex , Roudini Soheil , Moak Robert 
Published: January 2023

AbstractStoring and recovering water, carbon, and heat from geologic reservoirs is central to managing resources in a changing climate. We tested the hypothesis that the strain tensor caused by injecting or producing fluids can be measured at shallow depths and interpreted to advance understanding of underlying deep aquifers or reservoirs. Geodetic‐grade strainmeters were deployed at 30 m depth overlying the Bartlesville Formation, a 500‐m‐deep sandstone near Tulsa, OK. The strainmeters are 220 m east of injection well 9A completed in a permeable lens at the base of the Bartlesville Formation. Water was injected into well 9A at approximately 1.0 L/s during four tests that ranged in duration from a few hours to a few weeks. The horizontal strain increased (tension) and the circumferential strain was a few times larger than the radial strain. The vertical strain decreased (compression) during injection. Strain rates were approximately 100 nε/day during the first few hours, but the rates decreased and were approximately 10 nε/day during most of the tests. Four independent methods of poroelastic simulation and inversion predict reservoir properties and geometries that are similar to each other and consistent with independent information about the reservoir. All strain interpretations predict that a boundary to the permeable lens occurs beneath the vicinity of the strainmeters, which is consistent with core data from the site. The boundary of the permeable lens is located by matching the vertical, radial and circumferential strains, which demonstrates the value of measuring the strain tensor.
Impact of AMPK on cervical carcinoma progression and metastasis
Authors: Konieczny Paweł , Adamus Tomasz , Sułkowski Maciej , Skrzypek Klaudia , Majka Marcin 
Published: January 2023

AbstractCervical cancer (CC) is the fourth most common malignant neoplasm among women. Late diagnosis is directly associated with the incidence of metastatic disease and remarkably limits the effectiveness of conventional anticancer therapies at the advanced tumor stage. In this study, we investigated the role of 5’AMP-activated kinase (AMPK) in the metastatic progression of cervical cancer. Since the epithelial mesenchymal transition (EMT) is known as major mechanism enabling cancer cell metastasis, cell lines, which accurately represent this process, have been used as a research model. We used C-4I and HTB-35 cervical cancer cell lines representing distant stages of the disease, in which we genetically modified the expression of the AMPK catalytic subunit α. We have shown that tumor progression leads to metabolic deregulation which results in reduced expression and activity of AMPK. We also demonstrated that AMPK is related to the ability of cells to acquire invasive phenotype and potential for in vivo metastases, and its activity may inhibit these processes. Our findings support the hypothesis that AMPK is a promising therapeutic target and modulation of its expression and activity may improve the efficacy of cervical cancer treatment.
Dual inhibition of thioredoxin reductase and proteasome is required for auranofin-induced paraptosis in breast cancer cells
Authors: Seo Min Ji , Kim In Young , Lee Dong Min , Park Yeon Jung , Cho Mi-Young , Jin Hyo Joon , Choi Kyeong Sook 
Published: January 2023

AbstractAuranofin (AF), a gold (I)-containing phosphine compound, is being investigated for oncological application as a repurposed drug. We show here that 4~5 µM AF induces paraptosis, a non-apoptotic cell death mode characterized by dilation of the endoplasmic reticulum (ER) and mitochondria, in breast cancer cells. Although the covalent inhibition of thioredoxin reductase (TrxR), an enzyme that critically controls intracellular redox homeostasis, is considered the primary mechanism of AF’s anticancer activity, knockdown of TrxR1 did not induce paraptosis. Instead, both TrxR1 knockdown plus the proteasome inhibitor (PI), bortezomib (Bz), and 2 μM AF plus Bz induced paraptosis, thereby mimicking the effect of 5 μM AF. These results suggest that the paraptosis induced by 5 μM AF requires the inhibition of both TrxR1 and proteasome. We found that TrxR1 knockdown/Bz or subtoxic doses of AF and Bz induced paraptosis selectively in breast cancer cells, sparing non-transformed MCF10A cells, whereas 4~5 μM AF killed both cancer and MCF10A cells. GSH depletion was found to be more critical than ROS generation for the paraptosis induced by dual TrxR1/proteasome inhibition. In this process, the ATF4/CHAC1 (glutathione-specific gamma-glutamylcyclotransferase 1) axis leads to GSH degradation, contributing to proteotoxic stress possibly due to the accumulation of misfolded thiol-containing proteins. These results suggest that the paraptosis-inducing strategy of AF plus a PI may provide an effective therapeutic strategy against pro-apoptotic therapy-resistant cancers and reduce the potential side effects associated with high-dose AF.
PRMT5-mediated regulatory arginine methylation of RIPK3
Authors: Chauhan Chanchal , Martinez-Val Ana , Niedenthal Rainer , Olsen Jesper Velgaard , Kotlyarov Alexey , Bekker-Jensen Simon , Gaestel Matthias , Menon Manoj B. 
Published: January 2023

AbstractThe TNF receptor-interacting protein kinases (RIPK)-1 and 3 are regulators of extrinsic cell death response pathways, where RIPK1 makes the cell survival or death decisions by associating with distinct complexes mediating survival signaling, caspase activation or RIPK3-dependent necroptotic cell death in a context-dependent manner. Using a mass spectrometry-based screen to find new components of the ripoptosome/necrosome, we discovered the protein-arginine methyltransferase (PRMT)-5 as a direct interaction partner of RIPK1. Interestingly, RIPK3 but not RIPK1 was then found to be a target of PRMT5-mediated symmetric arginine dimethylation. A conserved arginine residue in RIPK3 (R486 in human, R415 in mouse) was identified as the evolutionarily conserved target for PRMT5-mediated symmetric dimethylation and the mutations R486A and R486K in human RIPK3 almost completely abrogated its methylation. Rescue experiments using these non-methylatable mutants of RIPK3 demonstrated PRMT5-mediated RIPK3 methylation to act as an efficient mechanism of RIPK3-mediated feedback control on RIPK1 activity and function. Therefore, this study reveals PRMT5-mediated RIPK3 methylation as a novel modulator of RIPK1-dependent signaling.