bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reproductive characteristics of indigenous village chickens
Authors: Desta Takele Taye , Wakeyo Oli 
Published: April 2023

Abstract
Indigenous village chickens (IVCs) display a wide variation in production performance and reproductive characteristics. This variation is ascribed to genetic and environmental factors and gene-environment interactions. This work reports the results of a cross-sectional study recorded using a face-to-face interview of 119 small-scale farmers regarding their insights on production performance and reproductive characteristics of IVCs. It was reported that pullets were sexually mature on average at the age of 5.5 months and cockerels at 6 months. This comparatively early sexual maturity by the standards of IVCs might be attributed to the impact of uncontrolled gene flow from production breeds. However, there is a wide variation in age at sexual maturity at an individual bird’s level. It was found that pullets mature earlier than cockerels (t = 3.250, df = 159, p = 0.001, 95%: CI -0.670, -0.166). Reportedly, local hens on average laid 14 eggs per clutch. The mean number of clutches per year was 4, which could culminate in the yearly production of 56 eggs. A significantly large proportion of the respondents reported that the warm season is an ideal time for laying eggs (96.7%) and brooding chicks (94.1%). During the dry season, the scavenging feed resource is relatively abundant, the risk of infection is comparatively low, and the warm weather is suitable for laying eggs and brooding chicks. IVCs possess a long reproductive lifetime, i.e., on average 3 years in hens and 2 years in cocks, which makes them more productive than has been anticipated. For example, this study found that a hen on average can lay 174 eggs and hatch 58 chicks in its average reproductive lifetime of 3 years. The high intrapopulation variation observed in the performance of IVCs can be used in genetic improvement programs.
Identification and Potential Value of Candidate Genes in Patients with Sinonasal inverted papilloma
Authors: Xu Haiyan , Chen Gang , Li Tieqi 
Published: April 2023

Abstract
Background: This study aimed to explore candidate genes involved in the pathogenesis of sinonasal inverted papilloma (SNIP) using bioinformatic analysis and experimental verification.
Methods: For this, gene expression profiles (GSE193016) were downloaded from the Gene Expression Omnibus (GEO) database. Differentially expressed genes (DEGs) were identified, with Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) being used to analyze the functions and pathways of DEGs. Co-expression networks were established using single-sample gene set enrichment analysis (GSEA). Furthermore, Search Tool for the Retrieval of Interacting Genes (STRING), Cytoscape, Molecular Complex Detection (MCODE), and Cytohubba were used to construct protein–protein interaction (PPI) networks, screen hub DEGs, and identify hub genes, with a miRNA-TF-hub gene regulatory network also being constructed. Finally, expression levels of identified hub genes were verified using RT-qPCR.
Results: As a result, 985 DEGs were identified, including 343 upregulated and 642 downregulated genes. Functional enrichment analyses showed that upregulated DEGs were significantly enriched in epidermal development, cornification, keratinocyte differentiation, epidermal cell differentiation, and skin development. Meanwhile, downregulated DEGs were significantly enriched in muscle contraction, extracellular structure organization, muscle system process, extracellular matrix organization, and regulation of membrane potential. The top eight hub genes were MAD2L1, CDC20, CCNB2, CCNB1, AURKB, NDC80, KIF11, and DLGAP5. During the validation stage, the expression of MAD2L1 was significantly higher in patients with SNIP than in those with normal nasal mucosa.
Conclusions: Overall, this study identified key genes associated with SNIP and their biological functions. Furthermore, a variety of predicted genes involved in the cell cycle were found to be connected to SNIP pathogenesis and malignant transformation. MAD2L1may play an important role in SNIP pathogenesis, providing novel insights into the occurrence and development of SNIP.
Comparative analysis through computer modeling of the mechanical strength of conventional reinforced concrete beams and beams with non-metallic reinforcements
Authors: LINHARES Paulo Robson Parente , MAGALHÃES Jamylly Kettyly Da Costa , de SOUSA Syllas Ferreira , TEIXEIRA Karla Rayane Sousa , SAMPAIO Allefy Teles 
Published: April 2023

Abstract
Traditional reinforced concrete is one of the most used components in structures in Brazil. This is due to its characteristics of workability, mechanical resistance, and practicality in execution. However, this component usually presents, throughout its useful life, several pathological manifestations related to steel reinforcements. For this reason the construction industry has sought to develop materials with characteristics of high mechanical performance and that present high durability throughout their useful life. It is in this context that non-metallic reinforcements based on fiber-reinforced polymers (FRPs) have emerged. Thus, the work presents an experiment that compares the mechanical strength of concrete beams with non-metallic reinforcements to the mechanical strength of beam with reinforced concrete with metal reinforcement. This study seeks to verify if there is technical feasibility of replacing steel reinforcement by these materials, thus enhancing the durability of the structure and reducing the need for maintenance or interventions throughout its useful life. The result of the study shows that both the beam reinforced with bars of polymers reinforced with glass fibers (GFRP) and the beam with mesh of polymers reinforced with glass fibers (GFRP) presented good characteristics of mechanical resistance when subjected to loading until its rupture. With this it was possible to conclude that in addition to the non-metallic reinforcements provide the reduction of incidence of pathological manifestations in the structure, these still meet the high performance requirements required for the structural parts studied.
Computed tomography (CT) scanned renal cyst and pathological multilocular cystic renal neoplasm of low malignant potential (MCRNLMP): a patients’ management report of 1520 cases
Authors: Gao Wenlong , Yu Jianpeng , Zhang Mingpeng , Wang Guixin , Li Gang , Niu Yuanjie 
Published: April 2023

Abstract
Background The association between computed tomography (CT) imaging characteristics and clinical growth rate of multilocular cystic renal neoplasm of low malignant potential (MCRNLMP) have not been reported. Our study focused on the correlation of CT imaging and growth rate to investigate the distinguished characteristics in MCRNLMP versus renal cysts, and explore the optimized management.Methods Data regarding 1520 patients including 1,444 patients with renal cysts and 76 patients with MCRNLMP who underwent renal cyst decompression, radical nephrectomy, or nephron sparing surgery due to renal cystic disease between Jan 2013 and Dec 2021 in our institution were retrospectively collected and analyzed. Bosniak classification for imaging modality and the 2016 WHO criteria for clinic pathology were used for detection of MCRNLMP.Results In our study, MCRNLMP accounted for 1.48% of patients with “simple renal cysts”, 5.26% of the patients with “complex renal cysts”, and 12.11% of the patients with “renal tumors combined with renal cysts” (P < 0.001); MCRNLMP accounted for 22.37% and 0.66% of patients with cysts’ growth rate ≥ 2.0 cm/year and < 2.0 cm/year, repectively. Of 76 MCRNLMP cases, after renal cyst de-topping decompression, no recurrence or metastasis was found in 9 patients who underwent nephron-sparing surgery or radical nephrectomy again, while only 1 suspicious recurrence was found by CT of 67 patients underwent actively monitored in postoperative 3-year follow-up.Conclusions MCRNLMP and renal cysts can be slightly identified through the potential predictors of Computed tomography (CT) scanning and growth rate. For MCRNLMP, partial nephrectomy is the first choice and radical nephrectomy should be avoided as much as possible, in addition, active monitoring can also be adopted after surgery to avoid unnecessary nephrectomy.
Impedance mismatch derived coded absorbing materials: for ultra-broadband anti-reflection and scattering field tailored on demand
Authors: Chen Wei , Duan Yuping , Liu Jiangyong , Zhang Tuo , Shi Yupeng , Ma Xinran , Huang Lingxi , Pang Huifang 
Published: April 2023

Abstract
The inability of existing electromagnetic wave absorbing materials (EAMs) to manipulate electromagnetic waves in multiple dimensions leads to the failure to satisfy the demands placed on electromagnetic (EM) defense technology by the current complex EM environment. To break this dilemma, this study focuses on the impedance properties of EAMs, conferring additional ability to disperse and deflect reflected waves by encoding EAMs with opposite phase responses in different impedance mismatch modes. Due to the synergy of both absorption and scattering mechanisms, the developed scattering metasurface absorber exhibits excellent anti-reflection performance, with reflectivity below 0.1 in the 7.8-16.7 GHz at 2 mm thickness. Furthermore, a genetic algorithm is employed to tailor the desired scattering field to meet the stealth requirements of specific environments, allowing for the directional transmission of EM energy in the one-dimensional or homogeneous distribution in the three-dimensional. The proposed scattering metasurface absorber constructed by coded EAMs exhibited excellent anti-reflection properties and environmental stealth adaptability, opening up new possibilities for the development of advanced EM defense technology.
A Potential Molecular Inhibitor of the SARS-COV-2 Main Protease Obtained by Virtual Screening
Authors: Liu Nanxin , Yang Zeyu , Liu Yuying , Dang Xintao , Zhang Qingqing , Wang Jin , Liu Xueying , Zhang Jie , Pan Xiaoyan 
Published: April 2023

Abstract
SARS-CoV-2 has been out breaking around the world for more than three years and continues to evolve variants, which has become a major global health threat. Main protease (Mpro, also called 3CLpro) plays a key role in viral replication and proliferation, making it an attractive drug target. Here, we have identified novel potential inhibitor of Mpro by applying a virtual screening of hundreds Nilotinib structure-like compounds we designed and synthesized. The screened compounds were followed for the SP docking, XP docking, MM-GBSA analysis, IFD docking, MD simulation, ADME/T prediction and then enzymatic assay in vitro. We finally identified compound V291 as a potential SARS-COV-2 Mpro inhibitor with high docking affinity and enzyme inhibitory activity. Moreover, the docking results indicate that His41 is a favorable amino acid for pi-pi inter-actions, while Glu166 can participate in salt bridge formation with protonated primary or secondary amines in the screened molecules. Thus, compounds reported here are capable of engaging the key amino acids His41 and Glu166 in ligand-receptor interactions. Pharmacophore analysis further validates this assertion.
Needle tract seeding of papillary thyroid carcinoma after fine needle aspiration: A case report
Authors: Shi Yang , Zheng Yuenan , Shao Liang , Lv Chengzhou , Zhang Hao , Dong Wenwu , Zhang Ping 
Published: April 2023

Abstract
Background Fine needle aspiration (FNA) is an important and economical technique for the diagnosis of thyroid nodules. Needle tract seeding (NTS) is a rare complication of FNA. The location and number of NTS that occurred in our patient differed from other case reports. Thus, we report a case of papillary thyroid carcinoma (PTC) with needle implantation.Case report: We report a 34-year-old man with papillary thyroid carcinoma (PTC) who developed tumor dissemination around the sternocleidomastoid muscle 5 years after FNA and radiofrequency ablation (RFA). The diagnosis of NTS is based on imaging (computed tomography and ultrasound), postoperative pathology. Metastatic deposits appeared in the muscle which implied that seeding most probably resulted from FNA.Conclusion FNA is a safe procedure and NTS is rare and can be surgically removed. Therefore, the benefits of FNA far outweigh the risks associated with complications.
Computational Intelligence Approach in Optimizing the Resource Allocation for Workflow Execution in the Cloud
Authors: KANAGARAJ K , SWAMYNATHAN S , RADHA P 
Published: April 2023

Abstract
Virtual Machine (VM) assignment is an important phase during workflow execution in the cloud. Identifying a suitable type of VM for executing the workflow is a difficult problem. Cloud resource providers offer diverse categories of VMs to cater the needs of the users and encourage the users to select an appropriate type of VM to reduce the workflow execution time and cost. A suitable VM type can be selected only if the resource requirements of the workflow is known, which a difficult task for cloud users till now. Hence many users depend on general purpose VMs, rather than using a suitable type of VM for their application. This work proposes an intelligent recommendation system that helps the cloud users to select suitable type of VM for their application. The main objective of this work is to identify the type of the workflow using computational intelligence and to recommend a sutitable type of VM for execution. The system uses three supervised learning algorithms such as Probabilistic Neural network (PNN) , Deep Forward Neural Network (DFNN) and Naïve Bayes classier for workflow classification. The Bayes classifier is found be very accurate for workflow classification, when compared to the other algorithms. Also the relative optimality of the classifier is tested using popular workflow scheduling algorithms like ICPCP (IAAS Cloud Partial Critical Path algorithm), MER (Maximum Effective Reduction) and LBS (Level Based Scheduling). The results confirm that the workflow execution time and cost are reduced to a great extent, when executing a workflow using a suitable type of VM than with the general purpose VM.
Probing optical anapoles with fast electron beams
Authors: Shegai Timur , Maciel-Escudero Carlos , Yankovich Andrew , Munkhbat Battulga , Baranov Denis , Hillenbrand Rainer , Olsson Eva , Aizpurua Javier 
Published: April 2023

Abstract
Optical anapoles are intriguing charge-current distributions characterized by a
strong suppression of electromagnetic radiation. They originate from the destructive interference of the radiation produced by electric and toroidal multipoles. Although anapoles in dielectric structures have been probed and mapped with a combination of near- and far-field optical techniques, their excitation using fast
electron beams has not been explored so far. Here, we theoretically and experimentally analyze the excitation of optical anapoles in tungsten disulfide (WS2)nanodisks using Electron Energy Loss Spectroscopy (EELS) in Scanning Transmission Electron Microscopy (STEM). We observe prominent dips in the electron energy loss spectra and associate them with the excitation of optical anapoles and anapole-exciton hybrids. We are able to map the anapoles excited in the WS2 nanodisks with subnanometer resolution and find that their excitation can be controlled by placing the electron beam at different positions on the nanodisk. Considering current research on the anapole phenomenon, we envision EELS in STEM to become a useful tool for accessing optical anapoles appearing in a variety of dielectric nanoresonators.
An Efficient and Accurate Numerical Method for the Bessel Transform with an Irregular Oscillator and Its Error Analysis
Authors: Wang Hong , Kang Hongchao , Ma Junjie 
Published: April 2023

Abstract
In this paper we present and analyze an efficient numerical scheme for computing the Bessel transform with an irregular oscillator. Especially in the presence of critical points, e.g., endpoints, zeros and stationary points for the general oscillator g(x), we derive a series of new quadrature formulae for such transform and carry out rigorous analysis for the proposed numerical method. The error analysis demonstrates that this method exhibits high asymptotic order, and the accuracy improves drastically with either increasing the frequency $\omega$ or adding more nodes. Compared with the existing modified Filon-type method, the established approach shows higher precision and error order at the same computational cost. The abundant numerical examples are provided to verify the theoretical results and illustrate the efficiency and accuracy of the proposed method.
Mathematics Subject Classification (2000) 65D30 · 65D32 · 65R10 · 41A60
Patient Characteristics Associated with Definitive Diagnosis of Metastatic Pancreatic Cancer in Those Initially Diagnosed with Cancer of Unknown Primary
Authors: White Larissa , Smith-Gagen Julie , Elliott Leslie , Lu Minggen 
Published: April 2023

Abstract
Purpose. Cancer of unknown primary (CUP) is the fourth most common cause of cancer mortality in the U.S. Median survival after CUP diagnosis is 3-4 months. As CUP and metastatic pancreatic cancer (PC) are comparable in prevalence and survival, PC diagnosis is a useful endpoint to assess patient characteristics associated with definitive diagnosis in older patients who initially present with CUP.
Methods. This study used 2010-2015 SEER-Medicare data. Logistic regression models compared patient characteristics who received definitive diagnosis in two subsets: CUP-PC and PC only.
Results. Approximately 26% of patients who received a definitive diagnosis of metastatic pancreatic cancer started with an initial diagnosis of CUP (n=17,565). The odds of definitive diagnosis in CUP-PC were lower for those with a comorbidity score of 0 (OR 0.85 [0.79, 0.91]) and epithelial/unspecified histology (OR 0.76 [0.71, 0.82]). The odds of definitive diagnosis in CUP-PC were higher for patients of Other race (OR 1.27 [1.13, 1.43]) compared to White patients.
Conclusion. Definitive diagnosis of CUP-PC was favorable in patients in the Other race category with fewer or no comorbidities. Unfavorable characteristics included older patients and those with epithelial/unspecified histology. Future studies will focus on patterns of care and survival in patients with CUP-PC.
Left Superior Vena Cava Draining to Left Atrium: a Case Report, Review of the Literature, and Classification
Authors: Bisbee Cora R. , Sherard Curry , Rajab Taufiek Konrad 
Published: April 2023

Abstract
Persistent left superior vena cava (PLSVC) draining to the left atrium (LA) is a rare congenital abnormality. PLSVC usually drains into the right atrium via the coronary sinus. In 20% of patients, however, it can connect to the LA [1]. Left atrial drainage occurs through the LA appendage, left pulmonary veins, or the coronary sinus. Patients are often asymptomatic as the left atrial drainage does not result in a significant right to left shunt. As such, the abnormality is often discovered incidentally on imaging. PLSVC is often described in conjunction with other congenital anomalies, such as atrial septal defect (ASD), tetralogy of fallot, and coarctation of the aorta [2]. When PLSVC draining to the LA is present in the setting of an ASD, it is classified as Raghib’s syndrome. However, this case describes a PLSVC draining to the LA without an ASD or a right SVC, a presentation which has never before been described.
Development of 3, 3′-diindolylmethane incorporated with chitosan nanoparticles for enhancing the anticancer efficiency against breast cancer through targeting apoptosis signalling axis
Authors: Stainsloss Isabella , Sankaran Mirunalini , Kannaiyan Pandiyan 
Published: April 2023

Abstract
Purpose: 3, 3’-diindolymethane (DIM) is a phytochemical that exhibits an extensive variety of pharmacological activities and its properties such as low bioavailability and dissolubility have impeded its clinical improvement. In this manner, there is a keen interest in studying whether the nano formulation of DIM combined with chitosan would be more efficient.
Methods: Ionic gelation is a viable method for preparing nanoparticles for delivery to human mammary cancer cell line (MCF-7). The nanoparticles were synthesized and characterized by the methods of UV spectrophotometer, Zeta Sizer, Particle size analyzer, Fourier transforms infrared spectroscopy (FT-IR), scanning electron microscopy (SEM). Further, we have scrutinized the therapeutic efficacy of DIM-CS-NP in MCF-7 by using MTT, biochemical analysis, acridine orange/ethidium bromide, rhodamine-123, comet assay and western blotting analysis in MCF-7 cells.
Results and discussion: The encapsulated DIM spheres with an average diameter of 50-100 nm exhibited high encapsulation efficiency and loading efficacy of 95.80±1.25% and 36.70±2.41% respectively. Furthermore, mammary cancer cells treated with encapsulated DIM inhibit cellular proliferation, promotion of mutation and genetic inability by induced apoptosis through intrinsic apoptotic signaling pathways.
Conclusion: Hence, DIM encapsulated chitosan nanoparticles have proved to be a highly effective form of drug targeted delivery in cancer treatment. In conclusion, the result shows that this novel formulation may overcome the current limitations of DIM to provide a new treatment approach for mammary cancer.
The effects of stay-at-home orders and their associated factors in elderly Koreans and Korean-Americans during COVID-19
Authors: Nam Hae Kweun , Lee Hocheol , Zhao Bo , Oh Hyunsung , Nam Eun Woo , Koh Sangbaek 
Published: April 2023

Abstract
Objective: The coronavirus pandemic has caused several people to feel isolated. Therefore, we conducted a cross-sectional study on 23 Korean and Korean-Americans to determine their general characteristics, loneliness, depression, and cognitive function.
Methods: We investigated the possible relationships between these variables and the duration of staying at home due to coronavirus disease 2019 (COVID-19). Mann–Whitney U and Fisher’s exact tests were used for continuous and categorical variables, respectively. Stepwise multivariate regression analysis was performed to investigate the relationships between the variables.
Results: Depression scores were higher in the Korean participants, and no difference was found in loneliness or cognitive function. The multivariate regression analysis results indicated that the duration of staying at home due to COVID-19 negatively associated with depression scores.
Conclusions: Depression in the elderly Korean population should be assessed and managed using efficient healthcare approaches. Studies with large cohorts are needed to investigate whether a sense of security affects depression in older adults who stay at home to avoid COVID-19.