bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of Newly Synthesized Compounds Targeting Carbonic Anhydrase Enzyme for Antineoplastic Activity in Solid Tumors
Authors: Naji Esraa M. , Hussein Sahar A. , Naser Noor H. 
Published: September 2023

Objective: This study was conducted with the aim of assessing the antineoplastic potential of recently developed compounds, namely F3, F4, and F5. These compounds were designed to target the carbonic anhydrase enzyme in solid tumors.
Methods: The synthesis of these compounds involved the utilization of sulfanilamide, chloroacetylchloride, thiourea, benzyl chloride derivatives, and silver nitrate. Docking studies were carried out using the MOE software program version 2015.10, and the cytotoxic activity was predicted through the implementation of the MTT assay.
Results: The compounds that were synthesized displayed noteworthy antineoplastic activity, as evidenced by both in silico simulations and cell line investigations. Notably, Compound F5 exhibited an IC50 value of 9.02 μg/ml for MCF7 cells, signifying a substantial difference when compared to the IC50 value of cisplatin. Moreover, Compounds F3 and F4 exhibited higher S scores in the docking study compared to acetazolamide, implying a more robust binding affinity to the catalytic site of the receptor. The inclusion of a substituted thiazole ring contributed to increased flexibility and enhanced receptor interaction.
Conclusion: The synthetic compounds put forth in this study demonstrated notable antineoplastic properties. Furthermore, the complexation process notably augmented the inhibition of cancer cell growth, underscoring their potential as promising agents for combating cancer.
Slowing of Peripheral Nerve Conduction Velocity in Children and Adolescents With Type 1 Diabetes Is Predicted by Glucose Fluctuations
Authors: Oberhauser Sarah S. , l’Allemand Dagmar , Willems Erik P. , Gozzi Tiziana , Heldt Katrin , Eilers Miriam , Stasinaki Aikaterini , Lütschg Jürg , Broser Philip J. 
Published: September 2023

Nerve conduction velocity (NCV) abnormalities are the forerunners of diabetic peripheral neuropathy (DPN). Therefore, this study aimed to analyze the effect of glucose profile quality on NCV in children and young adults with type 1 diabetes. Fifty-three children age 5 to 23 years with type 1 diabetes were recruited to participate in the study, which was conducted prospectively at the Children’s Hospital of Eastern Switzerland from 2016 to 2022. Glycemic targets were recorded, and a cross-sectional nerve conduction study analyzing the peroneal, tibial, median motor, and median sensory nerves was performed. Data were compared with those of a control group of 50 healthy children. In the age- and height-matched diabetes subgroup aged 10–16 years, all four nerves showed significantly slower NCV, most pronounced for the peroneal nerve. Because height has a retarding effect on peroneal NCV, NCV was adjusted for height (dNCV). Peroneal dNCV correlated negatively with long-term glycated hemoglobin and highly significantly with glucose variability. Because high glucose variability clearly increases the risk of neuropathy, together with but also independently of the mean glucose level, this aspect of glycemic control should be given more attention in the care of individuals with diabetes.Article HighlightsThere is a strong need for the better identification of early subclinical manifestations of microvascular complications, such as diabetic peripheral neuropathy, in young individuals with diabetes. To identify peripheral neuropathy and contributing factors at an asymptomatic disease stage, and to exclude height as a known modifying factor, we performed association studies of height-adjusted nerve conduction velocity. We identified high glucose variability, especially the SD of mean glucose, as an unexpectedly strong predictor of slowed nerve conduction velocity. More attention should be paid to the goal of low glucose variability in the care of individuals with diabetes.
Ethnicity Affects A1C Levels in Patients With Diagnosed Type 2 Diabetes in Southern Israel
Authors: Treister-Goltzman Yulia , Liberty Idit F. , Peleg Roni 
Published: September 2023

Purpose
To assess whether ethnicity affects the association between A1C and fasting glucose in people with type 2 diabetes.

Methods
This investigation was an epidemiological, cross-sectional study based on computerized medical records of the Southern District of Clalit Health Services. The study population comprised patients ≥40 years of age with type 2 diabetes who underwent blood tests between 8 August 2015 and 20 July 2020. A normal-error multiple linear regression model was used to assess differences in associations among ethnic groups (i.e., Arabs, Ethiopian Jews, and non-Ethiopian Jews) and A1C.

Results
A total of 59,432 patients with type 2 diabetes were included in the study. Of these, 1,804 were Jews of Ethiopian origin, 49,296 were non-Ethiopian Jews, and 8,332 were Arabs. Compared with non-Ethiopian Jews, A1C levels were increased by 0.1% (1 mmol/mol) among Ethiopian Jews and by 0.3% (3 mmol/mol) among Arabs. Ethnicity was a strong predictor of A1C, explaining 0.6% of its variance. An A1C level of 7% (53 mmol/mol) correlated with fasting glucose levels of 141, 136, and 126 mg/dL in non-Ethiopian Jews, Ethiopian Jews, and Arabs, respectively.

Conclusion
Ethnic differences in A1C should be considered by clinicians, researchers, and policymakers.
Demographic Variables Associated With Diabetes Technology Awareness or Use in Adults With Type 2 Diabetes
Authors: Ye Yuting , Acevedo Mendez Bernardo A. , Izard Stephanie , Myers Alyson K. 
Published: September 2023

Background
Studies in populations with type 1 diabetes highlight racial/ethnic disparities in the use of diabetes technology; however, little is known about disparities among those with type 2 diabetes. This project investigates the racial/ethnic and socioeconomic disparities in diabetes technology awareness and use in adults with type 2 diabetes in the ambulatory setting.

Methods
Adults ≥40 years of age with type 2 diabetes in ambulatory care were invited to participate via an e-mail link to a de-identified REDCap (Research Electronic Data Capture) questionnaire. Variables, including awareness and use of continuous glucose monitoring (CGM) and insulin pumps, were summarized descriptively using frequencies and percentages and were compared across racial/ethnic groups, education level, and income using Pearson χ2 or Fisher exact tests.

Results
The study included 116 participants, most of whom (62%) were White, elderly Medicare recipients. Compared with White participants, those of racially/ethnically minoritized groups were less likely to be aware of CGM (P = 0.013) or insulin pumps (P = 0.001). Participants with a high school education or less were also less likely to be aware of insulin pumps (P = 0.041). Interestingly, neither awareness nor use of CGM or insulin pumps was found to be associated with income.

Conclusion
This cross-sectional analysis suggests that racially/ethnically minoritized groups and individuals with lower education have less awareness of CGM or insulin pumps.
PERANCANGAN APLIKASI PENCATATAN PEMBAYARAN PAJAK BERBASIS WEB PADA CV KKB
Authors: Wade Daniel Sathya Jyoti , Ayuningtyas Ayuningtyas 
Published: September 2023

Pembayaran pajak merupakan wujud dalam kewajiban kenegaraan yang berperan penting bagi para wajib pajak dengan bersama-sama ikut serta dalam melakukan kewajiban membayar pajak untuk membantu pembiayaan serta pembangunan nasional. Terutama pada orang yang sudah memiliki penghasilan wajib untuk ikut serta dalam pembayaran pajak. Seiring perkembangan zaman, sistem informasi sangat diperlukan dalam mengoperasikan proses bisnis suatu perusahaan. Sehingga perlu dilakukan penelitian untuk melakukan pencatatan data pembayaran pajak sesuai keperluan perusahaan tersebut. Penerapan metode pada penelitian ini dengan menggunakan metode Waterfall sebagai alur proses dalam pembuatan aplikasi. Berdasarkan hasil uji coba black box testing diperoleh aplikasi berjalan sesuai dengan fungsinya yaitu pengguna dapat mengakses aplikasi, pengelolaan data pembayaran dan kategori serta aplikasi dapat mencetak laporan per periode. Hasil penelitian diperoleh aplikasi yang mampu melakukan proses pencatatan dengan lebih mudah dan mengurangi tingkat kesalahan dalam pencatatan data, dan data tersebut secara otomatis tersimpan dan dapat dilihat sewaktu-waktu serta dimana saja.Keywords: Report; application; tax
Upgrading English Language Proficiency and Providing Optimum Nursing Care for Cardiac Patients: Perceptions of Non-native Nurses
Authors: Wannas Amr Selim , Hassan Inas Hussein 
Published: September 2023

Linguistic competence and effective communication are essential for providing optimum care for patients. Cardiac care is among the high-alert settings that require highly proficient nurses to be attentive and provide the best possible care for patients with heart problems. This research aims to measure the perceptions of non-native nurses towards the correlation between upgrading their English language proficiency level and providing optimum nursing care for cardiac patients. To this end, a mixed-method research design, qualitative and quantitative, was adopted in the study. First, a questionnaire was constructed and disseminated to 210 Egyptian nurses working at the Magdi Yacoub Foundation (MYF) in Aswan, Egypt. Yet, 127 nurses responded to the questionnaire. Secondly, to ensure the reliability of the research results, observation and interviews with a selected number of questionnaire takers were used as data collection instruments. Findings revealed that upgrading the English language proficiency level is believed to contribute to enhancing the performance of cardiac care nurses, their professionalism, and their learning autonomy. In addition, a taxonomy of the nurses’ uses of English for Specific Purposes has been constructed during the study. The proposed taxonomy was constructed from the data from the questionnaire, the interview, and the observation. It can be used to identify nurses’ needs when designing English-for-nurses courses. It is recommended that further research is conducted to investigate the correlation between the level of English language proficiency and the performance of nurses in other medical sub-domains.
Building a Qualitative Research Framework for Researching How Human Dignity is Realised in Judicial Proceedings†
Authors: Kleindienst Petra 
Published: September 2023

Abstract
The relationship between the judge and the parties to judicial proceedings must entail communication, including appropriate reactions, during the proceedings and be balanced and respectful, despite different views being held. Irrespective of a judge disagreeing with the parties and any actions by the parties in breach of the law, the judge is supposed to provide the parties with a genuine sense of respect. Judges thereby help realise the human dignity of the individuals involved in judicial proceedings. However, the abstract nature of the concept of human dignity means empirical research on the realisation of human dignity remains modest at the scientific level. This article builds a research framework for researching the ways in which the human dignity of an individual (more specifically, the accused person) is realised in the vertical relationships (judicial authority–individual) during criminal proceedings. In this respect, the article opens the door for future empirical research on the realisation of human dignity.
A Categorical Modelling Approach to Site and Growth of Eucalyptus Stands in Brazilian Eastern Amazon
Authors: Da Cunha Neto Ernandes Macedo , Araujo Emmanoella Costa Guaraná , Veras Hudson Franklin Pessoa , Pelissari Allan Libanio , Silva Thiago Cardoso , Corte Ana Paula Dalla , Sanquetta Carlos Roberto 
Published: September 2023

Theoretical framework: Site index cannot be generalized to different eucalyptus clonal stands, since each clone has a distinct growth and yield pattern, in which categorical variables may add site-specific effects to assess model's interregional variability. Objective: This study aimed to assess the statistical performance of site index, as well as growth and yield models in different configurations adding categorical variables. Method: The study was carried out in eucalyptus stands in Eastern Brazilian Amazon with three clones of different ages and a different number of trees. Traditional Schumacher’s site model was fitted with the addition of categorical clone variable. Beck-Della Bianca’s model was fitted by ordinary least squares (OLS) and two-stage least squares (2SLS), adding dominant height as site variable and including clone variable. Results and discussion: Schumacher’s clone model presented lower standard estimate error (9.50%) and higher adjusted coefficient of determination (0.61), correcting the lack of normality and homoscedasticity. 2SLS was more accurate than OLS for Beck-Della Bianca’s model. This model validation resulted in root-mean-squared error of 2.82% and bias of 0.03%. Research implications: Additive and multiplicative effects on site index resulted in polymorphism. Clone variable provided more parsimonious and accurate models to estimate site index and forest growth and yield, in which 2SLS was recommended for forest prognosis.
Meningkatkan Life Skills dan Mentalitas Pada Remaja Putus Sekolah Melalui Minat Berwirausaha
Authors: Amran Ellyana , Tajib Erny , Tanuwijaya Justine 
Published: September 2023

Jumlah angka remaja putus sekolah meningkat akibat masalah faktor sosial, ekonomi, perhatian orang tua serta media sosial yang bebas merajalela. Tujuan Pengabdian kepada Masyarakat (PkM) ini adalah untuk meningkatkan life skill dan mentalitas para remaja putus sekolah terhadap minat berwirausaha binaan Dinas Sosial Taruna Jaya 2 Jakarta. Metode yang digunakan adalah metode partisipatif. Hasil PkM menunjukkan bahwa secara umum peserta memiliki minat berwirausaha yang tinggi terkait pemahaman life skill dan mentalitas entrepreneurship. Walaupun tingkat kepercayaan diri serta pemahaman potensi diri masih rendah, akibat lingkungan kehidupan yang kurang kondusif. Implikasi dari PkM ini adalah diperlukan pendampingan yang intensif dari berbagai pihak terkait nilai-nilai etika sosial religius, dalam membentuk akhak yang mulia guna pengendalian tindakan mereka.
Experimental results of a waste-heat powered thermoacoustic refrigeration system for ships
Authors: Thiaucourt Jonas , Merino Laso Pedro , Eon Bruno 
Published: September 2023

Greenhouse gas emissions are a major concern for maritime transport. TheInternational Maritime Organization (IMO)presents Waste Heat Recovery Systems (WHRS) from engine exhaust gas as a viable solution to improve energy utilization and reduce greenhouse gas emissions for marine power plants. In this paper, we present an original thermoacoustic WHRS and its associated experimental setup for validation. This WHRS aims to transport heat from a lower to a higher temperature reservoir (heat pump) and maintain a fridge at 0 °C. For the experimental setup, exhaust gases from a 4-stroke marine diesel engine are used to generate pressure waves (work) in thermoacoustic engines. The main result is the Coefficient of Performance (COP) of the system, around 0.3, assessed for various cold loads. The first results estimate that the system could substitute part of the chiller cold production onboard. Also, a preliminary economic analysis suggests that this system could perform 2% fuel savings that allow for a payback time below one year.
Asymptomatic implant removal after fracture union based on request to remove. Is it worth considering, an Indian perspective?
Authors: Gupta Tej , Bawaskar Akshay Ashok , Kamboj Parul , Gurav Pratik Pandurang , Rai Sanjay 
Published: September 2023

Objectives
Hardware removals are among the commonly performed surgical procedures in orthopedics, but they sometimes prove quite difficult. The purpose of our study was to evaluate the risk, benefit and drawbacks of asymptomatic implant removal based on patients’ desire.

Material and Methods
A total of 105 patients who had been previously treated for a fracture and voluntarily wanted its removal and who did not report clinical indications or occasional regional pain were included in the study cohort.

Results
For the 105 patients surveyed, implant removals were performed in the leg (41 patients; 39%), the ankle joint (32 patients; 30%), the thigh (19 patients; 18%) and the forearm and the wrist (15 patients; 14%). The most common indication for removal was patients’ request in 66 (62.8%) cases. Altogether, 98 (93%) patients were satisfied because of the fulfillment of their desire, despite the instances of complication being frequent (32.8%).

Conclusion
In our study, we reported a surprisingly high rate of satisfied patients after surgical hardware removal once their requests for hardware removal were taken into consideration. However, it was closely associated with multiple risks. Therefore, judicious selection of actually eligible patients is highly recommended instead of the unqualified fulfilment of their requests for removal.
GAME TECHNOLOGIES AS A MEANS OF TEACHING A FOREIGN LANGUAGE TO STUDENTS IN A NON-LINGUISTIC UNIVERSITY
Authors: Щекочихина Е.В. 
Published: September 2023

В статье рассматривается роль игровых технологий в обучении иностранному языку студентов неязыковых вузов. Внимание уделяется вопросу о том, как игра может помочь преподавателю заинтересовать учащихся, повысить их мотивацию к изучению иностранного языка, создать благоприятную атмосферу на занятии, развить у студентов языковые навыки, необходимые для овладения иностранным языком.
The article deals with the role of game technologies in teaching a foreign language to students of non-linguistic universities. Special attention is paid to the question of how the game can help the teacher to interest students, increase their motivation to learn a foreign language, create a favorable atmosphere in the classroom, develop students ’ language skills necessary for mastering a foreign language.
game, motivation, foreign language communication, language skills, communicative competence.
Effectiveness of Guava Leaf Extract (Syzygium Aqueum) in Inhibiting The Growth of Bacteria Aggregatibacter Actinomycetemcomitans
Authors: Sudrajat Attidhira Citra Lestari , Hardhani Puspito Ratih , Sukmawati Ayuda Nur , Arnov Steffi Triany , Rimawati Noor 
Published: September 2023

The role of Aggregatibacter actinomycetemcomitans bacteria can lead to the occurrence of aggressive periodontitis. The bacterium infects periodontal tissue with its virulence factor. Antibacterial administration such as chlorhexidine mouthwash is one of the treatments for periodontal disease due to bacteria. Long-term use of chlorhexidine can cause irritation of the oral mucosa, burning sensation, changes in taste perception and the appearance of stains on the teeth. One alternative is to gargle the guava leaf extract water. The antibacterial effect of guava leaf extract is obtained from its chemical compounds, namely flavonoids, phenolics, alkaloids, ethanol and tannins. This research aims to know the potential of water guava leaf extract (Syzygium aqueum) in inhibiting the growth of Aggregatibacter actinomycetemcomitans bacteria. A literature review by reviewing research articles from Science Direct and Google Scholar using the keywords "Syzygium aqueum and Aggregatibacter actinomycetemcomitans". Guava leaves contain many derivatives of compounds such as flavonoids, alkaloids, tannins, saponins, and terpenoids. The content of these compounds can be used as antibacterial because they are effective in inhibiting the growth of bacteria. Water guava leaf extract (Syzygium aqueum) can inhibit the growth of Aggregatibacter actinomycetemcomitans bacteria.
СТРУКТУРА СТРАТЕГІЧНИХ КОМУНІКАЦІЙ ЯК ОСНОВА ЕФЕКТИВНОГО КОМУНІКАЦІЙНОГО МЕНЕДЖМЕНТУ УКРАЇНИ В УМОВАХ ВІЙНИ1
Authors: Юськів Богдан , Карпчук Наталія , Пелех Оксана 
Published: September 2023

Стратегічні комунікації є одним із проявів державної влади та інструментом у політичному й безпековому досягненні національних інтересів. Сучасні конфлікти мають форму гібридних дій у сфері використання інформації на основі мас-медіа та інтернету. Завданням стратегічних комунікацій є вплив на громадську думку, зміна культурних цінностей і коригування політичної системи через «перепрограмування» політичної культури. Зазначені наступальні дії можуть суттєво вплинути на обороноздатність і безпеку держави, впливаючи на свідомість населення. У статті розглянуто питання стратегічних комунікацій України під час російсько-української війни, яка розпочалася 24 лютого 2022 р. Автори розглядають стратегічні комунікації як систему, що складається з інваріантних і варіативних компонентів, котрі можуть бути спроєктовані в повідомленнях медіа. З одного боку, медіа є інструментом стратегічних комунікацій, а з іншого – стратегічні комунікації трансформуються, відображаючись у медіаповідомленнях. Мета дослідження – розкриття структури стратегічних комунікацій як основи комунікаційного менеджменту, яка характерна для періоду збройного конфлікту. Проаналізовано повідомлення телеграм-каналу Insider Ukraine за перші 100 днів російсько-української війни. На основі рефлексивного тематичного аналізу з використанням одностороннього дисперсійного аналізу з’ясовано, що стратегічні комунікації України в період війни складаються зтакихінваріантнихкомпонентів: інтерактивні комунікації України, оперативні комунікації України, позаоперативні комунікації України, оперативні та позаоперативні комунікації щодо РФ. Ці узагальнені компоненти мають свої підкомпоненти, інтенсивність або повна відсутність яких у повідомленнях медіа може бути пов’язана з конкретними подіями періоду війни. Це дослідження робить внесок у розуміння структури стратегічних комунікацій загалом і під час війни зокрема. Проведений аналіз інтернет-комунікацій потрібно розглядати як частину стратегічного управління комунікаціями, уключену в процес стратегічного планування оборони та безпеки країни.

1Це дослідження проведено в рамках напряму Erasmus+ модуля Жана Моне «Стратегічні комунікації ЄС: протидія деструктивним впливам» (№ 101047033 ERASMUS-JMO- 2021-MODULE).
E-PILKOTES SMK KARYA BHAKTI BREBES
Authors: Putri Mentari Arsita , Apriliani Dyah 
Published: September 2023

Voting adalah kegiatan yang sangat menentukan pada saat perhelatan pemilihan, persoalan yang menjadi fokus perhatian bagi panitia penyelenggara pemilihan adalah bagaimana proses pemungutan suara dapat menjamin azas langsung, umum, bebas, dan rahasia serta bagaimana hasil perhitungan suara dapat berlangsung jujur transparan, dan dapat diakses oleh publik. Salah satu kegiatan yang belum tersentuh teknologi yaitu proses opemilihan ketua organisasi siswa intra sekolah (OSIS), disekolah – sekolah semua prosesnya kebanykaan masih dilakukan secara manual, hal ini dirasa kurang efektif dengan berkembangnya teknologi sekarang ini. Untuk memnuhi hal tersebut maka dibangun sebuah aplikasi e-voting berbasis web php. Sistem ini dibangun menggunakan software macromedia dreamweaver dan dngan menggunakan bahasa pemrograman php. Sistem ini menggunakan browser untuk melaksanakan voting diharapkan akan memeberikan hasil voting yang akurat, cepat, dan terpercaya serta bisa mengurangi angka siswa yang tidak memilih dan tidak akan mengganggu proses belajar mengajar. Kata Kunci: e-voting, Aplikasi, PHP