bluuebunny/crossref_metadata_2025_split huggingface dataset:
Challenges for upscaling hydrological effectiveness of nature-based solution for adaptation to climate change in watersheds
Authors: Jeuken Ad , Ray Patrick , Penning Ellis , Bouaziz Laurene , Tracy Jacob , Wi Sunwook , McEvoy Sadie , Taner Ümit , Hegnauer Mark 
Published: September 2023

Abstract
This paper presents an analysis of future research and development needs to assess the effectiveness of nature-based solutions for climate adaptation in watersheds at scale using hydrological models. Two main questions are addressed: to what extent are hydrological model approaches able to support decision making on nature-based solutions and adaptation, and how well is this hydrological analysis embedded in the broader planning process? To support the research, case studies in Bhutan, Zimbabwe and the Netherlands are presented. The Climate Risk Informed Decision Analysis approach is used to structure the planning process. All three case studies demonstrate how the hydrological system and full landscape of land and water use in watersheds can be simulated to better understand hydrometeorological hazards under current and future climate. Also, simulations of nature-based solutions are demonstrated, which need creativity and profound expert knowledge. In contrast to the assessment of grey infrastructure, no rules or guidance exists for the hydrological assessment of nature-based solutions. Physically-based models are better able to support the understanding of the functioning of the ecohydrological system and, therefore, the effectiveness of adaptation using nature-based solutions. There are however trade-offs between the computational complexity, the computation time and the multiple scenarios and sensitivity analyses of adaptation options needed for climate stress testing. Often there is a lack of monitoring data for verification of model outcomes. Several recommendations on how to improve modelling in an adaptation process are given. In addition, it is recommended to develop and rectify a set of nature-based solutions performance indicators, rules and algorithms to be adopted in models in order to quantify the effectiveness of these solutions.
Human health impacts of dams and reservoirs: Neglected issues in a One Health perspective
Authors: Ramamurthy Racchana , Bleser Julia , Konradsen Flemming , Kibret Solomon , Opperman Jeff , You Liangzhi , Sloff Kees , McCartney Matthew , Fèvre Eric M. , Boelee Eline 
Published: September 2023

Abstract
Dams have often been constructed for hydropower, water storage and to support socio-economic development, particularly in areas of water stress. In many places, the water stored in human-made reservoirs is essential to meet the development objectives of water supply, agriculture, industry, energy generation and other sectors. However, in the absence of adequate foresight and planning, many past dams have had considerable negative impacts on ecosystems and the livelihoods of affected communities, resulting in conflicts and health hazards. While enhanced human health and well-being could be considered as the ultimate outcome of development programs, the public health impact of dams remains an issue that is often neglected by policy makers and investors. National policies and international guidelines, such as those of the World Commission on Dams, have been used to improve planning and impact assessment of dams. Here, we provide an analysis of four large dams, across three continents, and show that they had limited consistency with World Commission on Dams principles and guidelines. Moreover, health aspects were largely neglected during planning, construction and operation of these dams, but seriously undermine their intended benefits. This perspective paper discusses impacts of dams on energy and food, ecosystem health, inclusion, and ultimately human health and wellbeing. We argue that a One Health perspective, based on these four categories, can support the systematic consideration of environmental, animal, and human health determinants. A dedicated One Health approach to dams and reservoirs remains to be developed but could potentially improve how dams, both existing and future, support more inclusive development.
Evaluasi Konsumsi Makan dan Kepatuhan Konsumsi TTD terhadap Tingkat Kecukupan Zat Besi pada Remaja Putri di SMKN 1 Salatiga
Authors: Mangalik Gelora , Wijayanti Debora Brian Santika , Tampubolon Rifatolistia 
Published: September 2023

Background: Anemia is a nutritional problem, the 2018 Riskesdas data shows 48.9% of adolescent girls experience iron deficiency anemia. The government has made efforts to overcome the problem of anemia in adolescent girls through the provision of blood-supplementation tablets (TTD).Methods: This research used is descriptive with a quantitative approach, using a 2x24 hour instrument record, and the SQ-FFQ form. This study assesses the level of iron adequacy by looking at the data from the evaluation of food consumption which is expressed by the value of MAR (Mean Adequacy Ratio).Result: The results showed that respondents in consuming iron tablets were in the non-adherent category as much as 65%, the level of iron adequacy in the very poor category was 42.5%, the level of macronutrient intake in 42.5% of respondents experienced a severe level of deficit and the food intake of respondents was less varied.Conclusion : The conclusion of this study is an evaluation of food consumption average has a weight deficit, the food consumed does not vary, iron intake is not sufficient according to the AKG, and is not obedient in consuming TTD.
A review on corrosion and corrosion inhibition behaviors of magnesium alloy in ethylene glycol aqueous solution
Authors: Liu Sisi , Wang Yicun , Huang Hualiang , Huang Gangliang 
Published: September 2023

Abstract
Magnesium alloy is one of the most promising automotive lightweight materials, but its poor corrosion resistance seriously hinders its practical application in automotive engines. Corrosion inhibitor technology has the characteristics of small dosage, simple operation, low cost, and does not affect the heat dissipation of metals. Therefore, adding high-efficiency long-term corrosion inhibitors to automotive engine coolants is the simplest, most practical and effective way to realize the application of magnesium alloy in automotive engines. This paper reviewed the corrosion and corrosion inhibition behaviors of magnesium alloy in ethylene glycol aqueous solution. The effects of temperature, galvanic effect, water content, and anionic and acidic oxides on the corrosion of magnesium alloy in automotive coolant were summarized. The research, advantages and disadvantages of inorganic, organics small-molecule, polymer, and composite corrosion inhibitors for inhibiting the corrosion of magnesium alloy in ethylene glycol aqueous solution were also summarized. The construction of inorganic-polymer corrosion inhibitor composite films was proposed to realize the application of magnesium alloy in engine, which further enriched the corrosion theories and anti-corrosion technologies of magnesium alloy.
Cell-type specific anti-cancerous effects of nitro-oleic acid and its combination with gamma irradiation
Authors: Perecko Tomas , Pereckova Jana , Hoferova Zuzana , Falk Martin 
Published: September 2023

Abstract
Nitro-fatty acids (NFAs) are endogenous lipid mediators capable of post-translational modifications of selected regulatory proteins. Here, we investigated the anti-cancerous effects of nitro-oleic acid (NO2OA) and its combination with gamma irradiation on different cancer cell lines. The effects of NO2OA on cell death, cell cycle distribution, or expression of p21 and cyclin D1 proteins were analyzed in cancer (A-549, HT-29 and FaDu) or normal cell lines (HGF, HFF-1). Dose enhancement ratio at 50 % survival fraction (DERIC50) was calculated for samples pre-treated with NO2OA followed by gamma irradiation. NO2OA suppressed viability and induced apoptotic cell death. These effects were cell line specific but not in general selective for cancer cells. HT-29 cell line exerted higher sensitivity toward NO2OA treatment among cancer cell lines tested: induction of cell cycle arrest in the G2/M phase was associated with an increase in p21 and a decrease in cyclin D1 expression. Pre-treatment of HT-29 cells with NO2OA prior irradiation showed a significantly increased DERIC50, demonstrating radiosensitizing effects. In conclusion, NO2OA exhibited potential for combined chemoradiotherapy. Our results encourage the development of new NFAs with improved features for cancer chemoradiation.
A solid lipid particle formulation of long pepper extract reduces pain and astrocyte activation in a rat model of neuropathic pain
Authors: Iamjan Sri-arun , Veerasakul Siriluk , Thanoi Samur , Tiyaboonchai Waree , Nudmamud-Thanoi Sutisa 
Published: September 2023

Abstract

Objectives
To investigate the effects of solid lipid microparticle (SLM) creams containing a long pepper extract (LPE) or piperine on neuropathy-related pain and the expression of glial fibrillary acidic protein (GFAP) as a measure of astrogliosis.

Methods
Neuropathic pain in male Spraque Dawley rats was induced by sciatic nerve ligation (SNL) and followed by treatment with LPE-SLM, piperine-SLM, capsaicin or vehicle creams. The pain score was assessed by thermal hyperalgesia test. The GFAP expression in the spinal cord was determined by immunohistochemistry.

Results
Pain scores were significantly increased after SNL and decreased when treated by LPE-SLM. The number of GFAP immunopositive cells was significantly increased in the SNL rats. Treated by LPE-SLM and capsaicin creams resulted in a significant reduction of the number of GFAP immunopositive cells. The LPE-SLM treated rats showed greater effects than the piperine and capsaicin preparations.

Conclusions
The LPE-SLM cream has a potential effect on pain attenuation via a decrease of spinal astrocyte activation-related mechanism. The LPE in SLM preparation could provide an alternative therapeutic strategy for treating neuropathic pain.
Potential anti-cancer activity of Moringa oleifera derived bio-active compounds targeting hypoxia-inducible factor-1 alpha in breast cancer
Authors: Masarkar Neha , Ray Suman Kumar , Saleem Zirha , Mukherjee Sukhes 
Published: September 2023

Abstract
Breast cancer (BC) will become a highly detected malignancy in females worldwide in 2023, with over 2 million new cases. Studies have established the role of hypoxia-inducible factor-1α (HIF1α), a transcription factor that controls cellular response to hypoxic stress, and is essential for BC spread. HIF-1 is implicated in nearly every critical stage of the metastatic progression, including invasion, EMT, intravasation, extravasation, angiogenesis, and the formation of metastatic niches. HIF-1 overexpression has been associated with poor prognosis and increased mortality in BC patients. This is accomplished by controlling the expression of HIF-1 target genes involved in cell survival, angiogenesis, metabolism, and treatment resistance. Studies have indicated that inhibiting HIF-1 has an anti-cancer effect on its own and that inhibiting HIF-1-mediated signaling improves the efficacy of anti-cancer therapy. Approximately 74 % of recognized anti-cancer drugs are sourced from plant species. Studies on anti-cancer characteristics of phytochemicals derived from Moringa oleifera (MO), also known as the ‘Tree of Life’, have revealed a high therapeutic potential for BC. In this review, we have highlighted the various mechanisms through which bioactive compounds present in MO may modulate HIF and its regulatory genes/pathways, to prove their efficacy in treating and preventing BC.
Kant’s Transcendental Theory of Universal Grammar. The Cognitive Foundation of the Structure of Language
Authors: D’Agostino Pierluigi 
Published: September 2023

Abstract
In this paper I discuss Kant’s philosophy of grammar in order to argue that: (a) the formal analysis of language implies that there is a structural correspondence between logical and grammatical form; (b) there is a distinction between the sense in which logic is formal and the sense in which grammar is formal; (c) universal grammar descends from the system of categorial functions that are investigated in the transcendental analytic; (d) transcendental grammar implies that the universal form of human language has its ground in the universal structure of thought; (e) the concept of a grammatical norm is clarified once we combine the theory of universal grammar with how linguistic experience takes place.
Kant on Language, Communication and Objective Judgment
Authors: Saarni Matti 
Published: September 2023

Abstract
This paper explicates the role of language and communication in Kant’s account of objective judgment and objective reference. I take it that the basic units of proper objective reference for Kant are objective judgments, which according to Kant are acts of relating given cognitions to other cognitions in the unity of apperception. The question is, does language play any role in this activity, or is this activity reflected in language somehow? I argue that, unlike early critics such as Herder and Hamann (and many after them) have suggested, Kant does not overall neglect language and communication in his philosophy, but rather can be taken to give an account of how it is possible to use language objectively and communicate objective judgments in the first place. Even though I do not find it a plausible view that according to Kant there is no thinking at all without or prior to language, Kant’s account does not rule out the importance of language for our thinking, judging and communicating. My claim is that Kant’s account of categorical experience as universal and necessary cognition of objects provides a ground for languages and their objective use, that is, for the possibility of objective reference in language.
IMMT promotes hepatocellular carcinoma formation via PI3K/AKT/mTOR pathway
Authors: Wang Jiabei , Zhang Yunguang , Sun Linmao , Liu Yao 
Published: September 2023

Abstract

Objectives
Hepatocellular carcinoma (HCC) remains a global challenge. Finding new specific targets has significant clinical value for the treatment of hepatocellular carcinoma. In this study, we discovered a new biomarker targeting HCC. At present, the role of Inner Membrane Mitochondrial Protein (IMMT) in various malignant tumors is receiving increasing attention, but its molecular mechanism of action in the malignant process of HCC has not been fully elucidated. This study aims to investigate the key regulatory mechanisms of IMMT in the formation of HCC.

Methods
Using TCGA data and clinical HCC samples, we first studied the expression of IMMT in HCC tissues and its correlation with malignant prognosis of patients. The regulatory effect of IMMT on HCC was studied by lentivirus infection. In vitro, the effects of IMMT on the proliferation, migration and apoptosis of cells were investigated by CCK8, colony formation assay, transwell and flow cytometry. Consistently, in vivo experiments, the regulation of tumor growth by IMMT was studied by constructing subcutaneous transplanted tumor and liver carcinoma in situ. In terms of mechanism, we predicted and verified the downstream genes of IMMT with the help of string database.

Results
We found that IMMT was significantly up-regulated in HCC tissues and was significantly positively correlated with poor prognosis of patients. Functionally, we demonstrated that IMMT knockdown significantly inhibited HCC cell proliferation, migration and promoted cell apoptosis in vitro. Similarly, the knockdown of IMMT also significantly weakened the progression of tumors in vivo. In terms of mechanism, we demonstrate for the first time that IMMT can regulate the progression of HCC by influencing the activation of PI3K-AKT-mTOR pathway.

Conclusions
Collectively, our research findings elucidate the hitherto unexplored important role of the IMMT/PI3K/AKT/mTOR axis in the formation of HCC, and provide a new biomarker for clinical diagnosis and treatment of HCC.
Development of an automated 3D metallography system and some first application examples in microstructural analysis
Authors: Lemiasheuski A. , Bajer E. , Oder G. , Göbel A. , Hesse R. , Pfennig A. , Bettge D. 
Published: September 2023

Abstract
Traditional metallography relies on the imaging of individual section planes. However, conclusions as to spatial shapes and microstructural arrangements can only be drawn to a limited extent. The idea to reconstruct three-dimensional microstructures from metallographic serial sections is therefore obvious and not at all new. However, the manual process of preparing a great number of individual sections and assembling them into image stacks is time-consuming and laborious and therefore constitutes an obstacle to frequent use. This is why the Federal Institute for Materials Research and Testing, or BAM for short (Bundesanstalt für Materialforschung und -prüfung), is developing a robot-assisted 3D metallography system performing the tasks of preparation and image acquisition on a metallographic section fully automatically and repeatedly. Preparation includes grinding, polishing and optional etching of the section surface. Image acquisition is performed using a light optical microscope with autofocus at several magnification levels. The obtained image stack is then pre-processed, segmented and converted to a 3D model resembling a microtomographic image, but with a higher lateral resolution at large volumes. As opposed to tomographic techniques, it is possible to perform traditional chemical etching for contrasting. The integration of a scanning electron microscope is in the planning stages. Studies conducted so far have demonstrated the possibility of visualizing hot gas corrosion layers, gray cast irons and ceramic-based microelectronic structures (vias).
Model Testing of Rock-Socketed Piles under Combined Vertical–Lateral Loading
Authors: Singh A. P. , Rao K. Seshagiri , Ayothiraman Ramanathan 
Published: September 2023

Abstract
This paper presents the findings from a model experimental setup designed and fabricated for conducting single gravity (1-g) model experiments on model aluminum instrumented piles embedded in synthetic rock subjected to both independent vertical–compressive and lateral loading and combined vertical–compressive and lateral loading. Synthetic rock was prepared based on a mix design that can simulate the strength and modulus of soft rocks. Model tests were carried out on single piles of different socketing lengths (L/D ratios: 6, 9, and 12). Combined loading tests were done such that the resultant of the vertical–compressive and lateral loads was at constant inclinations (30° and 60°). Piles with smooth and rough surfaces were simulated for examining the effect of the pile–rock roughness profile. The vertical load–settlement and the lateral load–deflection response were measured from the tests. The bending behavior of piles under both independent and combined loading was also measured. The deflection profile of the rock-socketed pile was obtained by tracing the tested/failed piles after extracting them. The axial and lateral resistance of the rock-socketed piles are interpreted and discussed. It is observed that the rock-socketed piles behave in a distinctly different manner under combined loading compared with independent loading.
Electrophysiological Signatures of Visual Recognition Memory across All Layers of Mouse V1
Authors: Hayden Dustin J. , Finnie Peter S. B. , Thomazeau Aurore , Li Alyssa Y. , Cooke Samuel F. , Bear Mark F. 
Published: September 2023

In mouse primary visual cortex (V1), familiar stimuli evoke significantly altered responses when compared with novel stimuli. This stimulus-selective response plasticity (SRP) was described originally as an increase in the magnitude of visual evoked potentials (VEPs) elicited in layer 4 (L4) by familiar phase-reversing grating stimuli. SRP is dependent on NMDA receptors (NMDARs) and has been hypothesized to reflect potentiation of thalamocortical (TC) synapses in L4. However, recent evidence indicates that the synaptic modifications that manifest as SRP do not occur on L4 principal cells. To shed light on where and how SRP is induced and expressed in male and female mice, the present study had three related aims: (1) to confirm that NMDAR are required specifically in glutamatergic principal neurons of V1, (2) to investigate the consequences of deleting NMDAR specifically in L6, and (3) to use translaminar electrophysiological recordings to characterize SRP expression in different layers of V1. We find that knock-out (KO) of NMDAR in L6 principal neurons disrupts SRP. Current-source density (CSD) analysis of the VEP depth profile shows augmentation of short latency current sinks in layers 3, 4, and 6 in response to phase reversals of familiar stimuli. Multiunit recordings demonstrate that increased peak firing occurs in response to phase reversals of familiar stimuli across all layers, but that activity between phase reversals is suppressed. Together, these data reveal important aspects of the underlying phenomenology of SRP and generate new hypotheses for the expression of experience-dependent plasticity in V1.SIGNIFICANCE STATEMENTRepeated exposure to stimuli that portend neither reward nor punishment leads to behavioral habituation, enabling organisms to dedicate attention to novel or otherwise significant features of the environment. The neural basis of this process, which is so often dysregulated in neurologic and psychiatric disorders, remains poorly understood. Learning and memory of stimulus familiarity can be studied in mouse visual cortex by measuring electrophysiological responses to simple phase-reversing grating stimuli. The current study advances knowledge of this process by documenting changes in visual evoked potentials (VEPs), neuronal spiking activity, and oscillations in the local field potentials (LFPs) across all layers of mouse visual cortex. In addition, we identify a key contribution of a specific population of neurons in layer 6 (L6) of visual cortex.