bluuebunny/crossref_metadata_2025_split huggingface dataset:
Functional Imaging of Mitochondria in Age-Related Macular Degeneration Using Flavoprotein Fluorescence
Authors: Muste Justin C. , Russell Matthew W. , Chen Andrew X. , Seth Kanika , Iyer Amogh I. , Valentim Carolina C. S. , Wu Anna K. , Kuo Blanche L. , Kalur Aneesha , Sastry Resya , Hom Grant L. , Conti Thais F. , Rich Collin A. , Talcott Katherine E. , Sharma Sumit , Singh Rishi P. 
Published: January 2023

Purpose:
Oxidative stress-induced mitochondrial dysfunction is implicated in the pathogenesis of age-related macular degeneration (AMD). Oxidized mitochondrial flavoprotein fluorescence (FPF) may serve as a quantifiable biomarker of oxidative stress, reported as either mean score for the entire image (intensity) or variability (heterogeneity). This study examines FPF intensity and heterogeneity across a large patient cohort of various Beckman stages of AMD.

Methods:
This study enrolled patients with isolated AMD and healthy control patients with no retinopathy between 2018 and 2021. Multivariate logistic regression analysis included stage of AMD, age, gender, ethnicity, and smoking status. Analysis of Variance test compared mean FPF intensity and heterogeneity between disease states.

Results:

Four hundred fifty-six eyes (228 AMD eyes, 228 age-matched control eyes) were included in the final multivariate analysis. Intermediate, geographic atrophy (GA), and neovascular AMD correlated with significantly increased FPF intensity (
P
< 0.001, respectively), while all AMD stages correlated with increased FPF heterogeneity (
P
< 0.001, respectively). FPF intensity and heterogeneity were significant negative predictors of visual acuity (
P
= 0.018 and 0.024, respectively).

Conclusions:
This prospective observational study further implicates mitochondrial damage in AMD pathophysiology. Long-term clinical trials will be needed to examine the predictive role of FPF imaging in patients over time.

[
Ophthalmic Surg Lasers Imaging Retina
2023;54:24–31.]
Impact of Instruction-based LEGO WeDo 2.0 Robotic and Hypermedia on Students’ Intrinsic Motivation to Learn Science
Authors: Ajlouni Aseel O 
Published: January 2023

Robots and hypermedia have been used as effective technological tools in the educational field. Despite their educational benefits, there are no studies investigating their impact on primary students’ intrinsic motivation in the field of science. For these reasons, the study aims to recognize the impact of employing LEGO WeDo 2.0 robotic and hypermedia on intrinsic motivation to learn science among primary students. The study implemented the quasi-experimental approach with a dual group design. The experimental group (n=25) was instructed on the force and motion topic using instruction-based LEGO WeDo 2.0 robotic and hypermedia, while the control group (n=25) was instructed using traditional instruction. The study conducted in Jordan involved fifty primary students. The data was gathered by administering the developed Intrinsic Motivation Towards Learning Science Scale to both groups at pre and post-points; ANCOVA analysis revealed a significant effect in favor of the experimental group in increasing intrinsic motivation to learn science at α = 0.05. These results recommend science instructors employ robots and hypermedia to foster students’ intrinsic motivation. It also encourages decision-makers in educational institutions to make decisions related to the science curriculum and its instructional methods.
L’art et la plasticité des genres
Authors: Combet Eric 
Published: January 2023

On emploie souvent aujourd’hui les termes « artiste » et « plasticien » comme synonymes. Sous cette simple manière de parler se dit une vérité troublante et profonde. Troublante, car la plasticité associe l’activité de la création d’une forme (la plastikê des Grecs) à la nécessaire destruction (le plasticage) de la forme initiale, de sorte que, si l’art est plastique, il est essentiellement lié à la perturbation et la transgression. Profonde, car cette plasticité ne serait pas le propre de notre modernité, et encore moins une idée relevant d’une mode intellectuelle passagère, mais l’essence intime de l’art à travers toute son histoire. On a voulu suggérer cela, en proposant le néologisme du « dianouménal » pour qualifier cette plasticité, et en remontant à l’art des cavernes pour en voir l’effectivité dès l’origine. Au Paléolithique, en effet, les Vénus gravettiennes par leur plastique androgyne sèment d’emblée le trouble dans le genre.
Use of Marsupialisation for a Conservative Approach to Huge Cystic Lesions of the Jaws - A Report of three Cases
Authors: Kolari Vinayakrishna , Dhabaria Husain , Sengupta Shreya , Sait Adil Iqbal , Shah Abhishek 
Published: January 2023

Rationale:
The management of cystic lesions of the jaws presents a challenge to the surgeon. Marsupialisation, one of the conservative management options, has been used as a single or combined surgical treatment modality for the cystic lesions of the jaws.

Patient Concerns:
All patients presented with a complaint of a firm swelling of the face with one of the patients presenting with paraesthesia in the affected area.

Diagnosis:
Clinical and radiographic examination was carried out followed by aspiration cytology. All lesions were provisionally diagnosed with odontogenic cystic lesions.

Treatment:
Marsupialisation under general anaesthesia was carried out for all patients. Postoperatively, a customised obturator was fabricated.

Outcomes:
All the patients showed good radiological ossification postoperatively.

Take-Away Lessons:
The approach to larger cysts remains controversial. The long-term results following the marsupialisation of extensive cysts of this report may help surgeons to opt for a conservative approach to such lesions before aggressive options.
Phleboliths of the Head and Neck Region - A Case Report
Authors: Abrantes Thamiris Castro , Barra Sâmila Gonçalves , Silva Leni Verônica Oliveira , Abrahão Aline Corrêa , Mesquita Ricardo Alves , Abreu Lucas Guimarães 
Published: January 2023

Rationale:
Phleboliths are idiopathic calcifications resulting from mineralised structures inside veins, venules or blood vessels.

Patient Concerns:
A 48-year-old woman presented with multiple hard bodies on palpation.

Diagnosis:
Imaging studies revealed multiple, round, well-defined radiopaque lesions, extending from the coronoid process region down to the base of the mandible. The diagnosis was vascular malformation with multiple phleboliths.

Treatment and Outcome:
No treatment was proposed and the patient is under follow-up.

Take-Away Lessons:
Asymptomatic phleboliths of the head and neck region in an adult woman have been under surveillance.
Evaluation of the Effects of Polidocanol Injection in the Treatment of Temporomandibular Joint Hypermobility - A Prospective Study
Authors: Vaidyanathan Aiswarya , Haidry Naqoosh , Sinha Upasna , Singh Abhishek , Salahudheen Ameera 
Published: January 2023

Introduction:
Sclerosing agents have been used for temporomandibular joint (TMJ) hypermobility since decades, some of which are ethanolamine oleate, and OK-432, sodium psylliate (sylnasol), but there are no studies on the usage of polidocanol – a well-known sclerosing agent which does not have much side effects and is inexpensive. Hence, this study evaluates the effect of polidocanol injection in the treatment of TMJ hypermobility.

Methodology:
This was a prospective observational study in which patients with chronic TMJ hypermobility were included. Out of the 44 patients who had symptoms of clicking and pain of the TMJ, 28 were diagnosed as internal derangement of the TMJ. The final analysis included 15 patients in whom multiple injections of polidocanol were given on the basis of post-operative parameters. The sample size was calculated based on a significance level of 0.05 and a power of 80%.

Results:
Overall, a success rate of 86.6% (13/15) was encountered at the end of three months, with seven patients not reporting any further episodes of dislocation after one injection and six patients not reporting any episode of dislocation after two injections.

Discussion:
Polidocanol sclerotherapy can be used as a treatment modality for chronic recurrent dislocation of the TMJ, rather than opting for more invasive procedures for the same.
Trigeminocardiac Reflex as a Complication of Excision of Schwannoma of the Trigeminal Nerve - A Rare Clinical Case Report
Authors: Anto Ronald , Riju Jeyashanth , Vidya Konduru , Tirkey Amit Jiwan 
Published: January 2023

Rationale:
Trigeminal schwannoma (TS) is a very rare tumour in the head-and-neck region and the occurrence of intraoperative trigeminocardiac reflex (TCR), during surgery, should not be underestimated. The physiological function of this rare brainstem reflex is yet to be fully established.

Patient Concerns:
TCR occurs in a variety of surgeries, such as neurosurgical, maxillofacial, dental and skull base surgeries with bradycardia as the presenting sign.

Diagnosis:
This is a clinical profile of two patients who presented with schwannoma of the trigeminal nerve.

Outcomes:
Intraoperatively, during dissection of tumour, both patients had bradycardia with hypotension.

Treatment:
The first patient had a spontaneous recovery but the other required intervention with vasopressors.

Take-Away Lessons:
One must be aware of the rare occurrence of TCR mainly while operating on a rare occurring TS. Ceaseless intraoperative monitoring and being prepared with adequate measures while manipulating close to the nerve will prevent serious complications.
Does the Impacted Mandibular Third Molar Increase the Risk of Angle Fracture to Prevent the Incidence of Condylar Fracture? – A Retrospective Analysis
Authors: Venkatachalam Vaishali , Pandiarajan Rajesh 
Published: January 2023

Introduction:
This study aimed to retrospectively analyse the influence of the presence or absence of third molars and its position on the incidence of angle and condylar fractures of mandible.

Methodology:
A retrospective cross-sectional analysis of 148 patients with mandibular fractures was done. A complete analysis of their clinical records and their radiological data was done. The primary predictor variable was the presence or absence of third molars and their positional status (Pell and Gregory’s classification) if present. The outcome variable was the type of fracture and other predictor variables included age, gender and fracture aetiology. Data were subjected to statistical analysis.

Results:
We observed that out of 48 patients with angle fractures, third molar was present in 67.34% and in 51.35% of 37 patients with condylar fractures, and there existed a positive correlation between the both. A significant association between the position of the teeth (Class II, III and Position B), angle fractures and (Class I, II, Position A) and condylar fractures was observed.

Conclusion:
Angular fractures were associated with superficial and deep impactions and condylar fractures were associated with superficial impactions. No association was observed with the age, gender or mechanism of injury to the pattern of fractures. Impacted mandibular molars increase the risk of angle fracture, thereby preventing the force transmission to the condyle, and the absence or a fully erupted tooth increases the risk of condylar fractures.
Accessory Maxilla in a Tessier 07 Cleft - A Case Report
Authors: Balaji S. M. , Balaji Preetha 
Published: January 2023

The Rationale:
Accessory maxilla is a rare condition often associated with Tessier type-7 clefts with fewer than 25 cases recorded in the literature. This manuscript reports a unilateral accessory maxilla with six supernumerary teeth.

Patient Concerns:
A 5-1/2-year-old boy, a treated macrostomia case, on follow-up visit showed evidence of accessory maxilla with teeth on radiological examination. The structure was interfering with growth, and hence, surgical removal was planned.

Diagnosis:
Based on clinical history, diagnosis and imaging, accessory maxilla with supernumerary teeth was diagnosed.

Treatment and Outcomes:
The accessory structures and teeth were removed surgically via an intraoral approach. Healing was uneventful. The growth deviation was arrested.

Take-Away Lessons:
Intraoral approach is a good option to remove an accessory maxilla. Tessier type-7 cleft may be accompanied by type-5 clefts and such accessory structures when impinging on vital structures such as temporomandibular joint or facial nerve should be immediately removed to facilitate proper form and function.
Stereophotogrammetric Method for Fabrication of Cranioplast Using Digital Facial Scan Technology - A Case Report
Authors: Gupta Abhishek Kumar , Gupta Rekha , Gill Shubhra , Bansal Kriti , Singh Nikita 
Published: January 2023

Rationale:
Traumatic brain injury is the most common cause of cranial defects. Cranioplasty is the surgical intervention performed to repair cranial defects. The purpose of a cranioplast is to protect the underlying brain tissues, reduce pain, and improve calvarial contour and symmetry.

Patient Concerns:
This case report describes the management of an ambulatory aided patient who met with a road traffic accident and had undergone decompressive craniectomy.

Diagnosis:
Noncontrast computed tomography confirmed the frontal cranial defect and was planned for decompressive craniectomy.

Treatment Plan:
An innovative multi-camera three-dimensional (3D) face-scanning software (Bellus 3D) was used for facial scanning to obtain a 3D face model and fabrication of 3D model using rich presence technology.

Outcomes:
The wax pattern was then fabricated on a 3D-prototyped model and a customised polymethylmethacrylate cranioplast was fabricated.

Take-Away Lessons:
his method with the added advantage of rapid prototyping technology resulted in prosthesis with good aesthetics and better fit.
Chronic Maxillary Atelectasis without Obstruction of the Maxillary Ostium - A Case Report
Authors: Numano Yuki , Nomura Kazuhiro , Hemmi Tomotaka , Suzuki Jun , Kakuta Risako , Sugawara Mitsuru 
Published: January 2023

Rationale:
Chronic maxillary atelectasis (CMA) is assumed to be caused by negative pressure in the maxillary sinus secondary to the obstruction of the ostiomeatal complex.

Patient Concerns:
A 49-year-old female patient first presented to our hospital complaining of right nasal congestion, rhinorrhoea and cheek pain.

Diagnosis:
Computed tomography (CT) accidentally revealed the inward bowing of the left maxillary sinus, which is a typical sign of CMA or silent sinus syndrome despite the maxillary ostium being potent.

Treatment:
We did not consider any intervention for CMA because she had no symptoms related to it.

Outcomes and Take-Away Lessons:
No progression was noted clinically or on CT at the 6-month follow-up. The pathogenesis of CMA in our patient was not explainable by the commonly accepted theory. Apparent hypertrophy of the left maxillary bone was confirmed on CT, thus osteitis with chronic rhinosinusitis might be the potential cause of CMA in the open maxillary sinus.
Extremely Large Submandibular Sialolith Removal - A Case Report
Authors: Mathew Justin , Pothanikat Joseph John K. , Kumar R. B. Vinod , Padikadan Naveen Odiyil , Arakkal Neeta Joy 
Published: January 2023

The Rationale:
Sialoliths are calcified organic matter that form within the secretory system of the salivary glands. They rarely measure more than 1.5 cm. Giant sialoliths are rare and defined as a size of 3.5 cm or larger.

Patient concerns:
Patient complained of the pain and swelling in the right submandibular area for two years with increase in size during meals.

Diagnosis:
Based on the clinical and radiological investigations.

Treatment:
Sialolith measuring 39 mm and weighing 7.02 g, was removed in a minimally invasive manner through transoral sialolithotomy using diode 810 mm LASER unit under local anaesthesia.

Outcomes:
Patient was relieved of the preoperative symptoms and was on follow-up for one year.

Take-Away Lessons:
Various newer treatment modalities are effective alternatives to conventional surgical treatment of sialoliths. However, transoral sialolithotomy remains the mainstay of management.
Assessment of Speech in Patients Undergoing Hemiglossectomy with Primary Closure and Radiotherapy - A Prospective Study
Authors: Dasgupta Sohini , Samuel Soumi 
Published: January 2023

Introduction:
The oral cavity plays a pivotal role in the generation of speech. The treatment of oral squamous cell carcinoma of the tongue requires an aggressive approach, combining resective surgery along with radiation therapy, with long-lasting effects on the patient’s ability to speak. This study was designed to assess speech in subjects with carcinoma of the tongue following hemiglossectomy with primary closure and radiotherapy.

Methods:
A prospective study was carried out in 20 subjects who underwent hemiglossectomy with primary closure for carcinoma of the tongue followed by radiotherapy. All subjects were evaluated for speech using ‘Kannada Diagnostic Photo Articulation Test’ before surgery, after surgery (on the 10th and 30th day), during radiation therapy after 15 fractions of radiation and after 1, 2 and 3 months following completion of radiotherapy. Statistical analysis was performed using SPSS software (v. 17.0). Significance levels were determined using ANOVA followed by Bonferroni correction.

Results:
Intelligibility of speech was noted to be affected most at the one month follow-up visit after completion of radiotherapy (P < 0.001). The Kannada Diagnostic Photo Articulation Test proves to be a useful tool in assessing changes in speech, with results that can be replicated in further studies.

Discussion:
The incidence of articulatory errors is increased following surgery and radiotherapy. Over time, the number of errors reduce and approach the baseline, indicating that although speech is indeed hampered by the treatment, with adequate speech therapy one can regain their preoperative articulation.
A comparative evaluation of bite pressure between single implant prosthesis and natural teeth
Authors: Singhal MK , Budakoti Vaibhav , Pratap Hemendra , Chourasiya Priyanka , Waghmare Anagha 
Published: January 2023

Aim of the Study:
To evaluate and compare bite pressure among individuals with implant prosthesis on one side and natural dentition on the contralateral side in the mandibular first molar region using the Nupai bite scan system.

Materials and Methods:
A total of 30 individuals (15 in which implant prosthesis on the right side and 15 in which implant prosthesis on the left side) with implant prosthesis on one side and natural dentition on the contralateral side participated in the study. The bite pressure was measured at the first molar area on both sides using Nupai bite scan.

Results:
Maximum bite pressure, average bite pressure, and the amount of the pressed area were found to be more on the natural dentition side in comparison to the side with implant prosthesis. The average pressure on natural teeth was 25.33 MPa and on implant prosthesis, 21.27 MPa.

Conclusion:
The present study concludes that the measured bite pressure at the natural dentition side is found to be higher than those at the fabricated implant prosthesis side. P value for average bite pressure is 0.033, which is significant (P < 0.05).
Cytogenetics Evaluation of 261 Couples with First-Trimester Recurrent Pregnancy Loss: A Prevalent Case–Control Study
Authors: Singhal Paresh , Raghavendra S. K. , Chakrabarty Barun Kumar , Pendkur Ganesh , Pendharkar Chinmay Shrikrishna , Sagoo Gurpreet Kaur 
Published: January 2023

Introduction:
Recurrent pregnancy loss (RPL) is a common occurrence which affects approximately 15-20% of couples. Chromosomal abnormality is an important cause of recurrent abortions especially if either of the partner is a carrier of balanced translocation. The current study aimed to determine the prevalence of chromosomal abnormalities in couples suffering from first trimester RPL and compare with normal control.

Materials and Methods:
A prospective case-control study, in which 261 couples with history of two or more abortions were evaluated for various chromosomal abnormalities; and compared with 190 healthy couples with no history of abortion and at least one normal biological child. Peripheral blood T-lymphocytes were cultured using RPMI-1640 medium for obtaining metaphases and chromosomal analysis. SPSS software and Student’s t test were used. p value < 0.05 was considered statistically significant.

Results:
Among 261 couples in RPL group, 240(91.95%) had normal karyotype, 17(6.51%) had major chromosomal abnormalities and 04(1.53%) had polymorphic variants. Most of the couples had two abortions (39.8%). Females were more commonly affected with M:F=0.214. Structural abnormalities (n=12,70.59%) were more frequent than numerical abnormalities (n=5,29.41%). There was no statistical correlation between age, number of abortions and major chromosomal abnormalities (p=0.06).

Conclusion:
Chromosomal aberrations in carrier parents, predispose them to RPL and can also be transmitted to the offspring which may results in imbalance in their genetic constitution, thus justifying the requirement of cytogenetic testing in these patients.
Commissioning Validation of a Brachytherapy Treatment Planning System with Egsnrc Monte Carlo Code and EBT3 GAFChromic Film
Authors: Lahlabou Mohammed , Khelifi Rachid 
Published: January 2023

Aims:
Most brachytherapy treatment planning system (TPS) commissioning requires data input based on the American Association of Physicists in Medicine Task Group-43 formalism. The commissioning accuracy is very important for dose calculation. The aim of this study is the implementation of a brachytherapy TPS into a clinical environment and check the TPS calculated dose accuracy.

Subjects and Methods:
After introducing data of the different catheters (CIS Bio International, Saclay, France), composed of several Cesium-137 Eckert and Ziegler BEBIG CSM-11 radioactive sources; for XiO (CMS, St. Louis) brachytherapy TPS, the TPS dose calculation accuracy was investigated by comparing between the TPS calculated dose distribution (DD) for all the catheters with (1) the measuring DD using EBT3 GAFChromic film and (2) calculating DD by egs_brachy (Electron Gamma Shower, National Research Council of Canada) Monte Carlo simulation. The phantom used for this study consists of six PTW slabs 30 cm × 30 cm × 1 cm of polymethyl methacrylate with a Delouche MEDpro applicator on the top. The TPS DD was calculated on the computed tomography scan of this phantom.

Statistical Analysis Used:
PTW VeriSoft version 6.0.1.7 (PTW-Freiburg, Germany) software was used for analyzing scanned films and to perform the comparison based on the gamma index distribution.

Results:
For each catheter, the gamma index distribution showed agreement >95% of all pixels in both verification methods, with gamma ≤1.

Conclusions:
We confirm the commissioning accuracy and that the TPS can be used for clinical purposes.