bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comprehensive progressive damage analyses of mixed‐mode repaired panels: How composite patch sizes and layups affects restarting fatigue crack growth
Authors: Hosseini‐Toudeshky Hossein , Sheibanian Fariborz , Sabzy Pourya , Jalalvand Meisam 
Published: June 2023

AbstractIn this paper, comprehensive progressive damage analyses are performed to evaluate the effects of patch sizes and layups on restarting crack growth of single‐side repaired aluminum panels with central inclined cracks under high cycle fatigue loading. Complicated nonlinear damage behavior of adhesive bonding, composite patch, mixed‐mode cracks, and fatigue loadings require precise numerical tools to consider and analyze the coupling effects of various damages on fatigue life of such complex component. In progressive damage analysis, high cycle fatigue cohesive zone modeling is used for debonding of patch, and high cycle fatigue continuum damage model used for composite patches. Practical composite patch layups and sizes are selected in huge number of models, and the restarting crack growth life is predicted. The obtained results show the possibility of increasing the restarting crack growth life using an appropriate composite patch layup and geometry dimensions.
Twice‐daily intake of bismuth‐based quadruple therapy for first‐line Helicobacter pylori eradication: A retrospective study on 10‐day, 14‐day, and half‐dose antibiotic therapy
Authors: Lee Sun‐Young , Kim Jeong Hwan , Sung In‐Kyung , Park Hyung Seok 
Published: June 2023

AbstractBackground/AimsIn areas with >15% clarithromycin resistance, bismuth‐based quadruple therapy is recommended for first‐line Helicobacter pylori eradication. This study aimed to determine the efficacy of the twice‐daily intake of bismuth‐based quadruple therapy among 10‐day, 14‐day, and half‐dose antibiotic regimens.MethodsFrom May 2021 to March 2023, H. pylori‐infected Korean adults were administered tetracycline (1 g), metronidazole (750 mg), bismuth potassium citrate (300 mg), and lansoprazole (30 mg) twice daily, after breakfast and dinner, for 10 days. The regimen was administered for 14 days if the body weight was ≥70 kg or if the patient had reinfection. Half doses of antibiotics were administered for 14 days if there was a risk of drug interactions or if the patient was aged ≥75 years. The 13C‐urea breath test was performed after 6 weeks.ResultsAmong the 1258 infected Koreans, 85.1% (412/484) in the 10‐day, 84.3% (498/591) in the 14‐day, and 86.3% (158/183) in the half‐dose antibiotic groups followed the instructions. In the per‐protocol (PP) analysis, eradication rates were higher in the 10‐day (90.5%, p = 0.019) and 14‐day (90.2%, p = 0.023) groups than in the half‐dose group (83.5%). In the intention‐to‐treat (ITT) analysis, eradication rates were higher in the 10‐day group (80.6%) than in the half‐dose group (73.2%, p = 0.039). In the half‐dose group, the eradication rate was lower in patients aged ≥75 years (PP: 74.6%, ITT: 66.2%) than in those with a risk of drug interactions (PP: 89.7% [p = 0.017], ITT: 82.4% [p = 0.019]).ConclusionsTwice‐daily intake of bismuth‐based quadruple therapy for 10–14 days showed an eradication rate of >90% in the PP analysis. A 10‐day regimen could be administered to eradication‐naive patients with a body weight below 70 kg. A half‐dose antibiotic regimen might be recommended to patients with a risk of drug interactions but not to those aged ≥75 years simply due to old age.
Determinants of the effectiveness of bezafibrate combined with ursodeoxycholic acid in patients with primary biliary cholangitis
Authors: Matsumoto Kosuke , Hirohara Junko , Takeuchi Akihito , Miura Ryo , Asaoka Yoshinari , Nakano Toshiaki , Tanaka Atsushi 
Published: June 2023

AbstractBackground and AimsFor patients with primary biliary cholangitis (PBC) exhibiting suboptimal responses to ursodeoxycholic acid (UDCA), obeticholic acid (OCA), and bezafibrate (BZF) are currently used and shown to improve long‐term outcomes. Nevertheless, we encounter patients who die or undergo liver transplantation (LT) even with combination treatment. In this study, we explored prognostic indicators in patients receiving combination treatment of UDCA and BZF.MethodsWe took advantage of the Japanese PBC registry and enrolled patients who received both UDCA and BZF therapy in 2000 or later. The covariates investigated included baseline covariates as well as treatment covariates. Two main outcomes (all‐cause death or LT and liver‐related death or LT) were assessed using multivariable‐adjusted Cox proportional hazards models.ResultsIn total, 772 patients were included. The median follow‐up was 7.1 years. Using the Cox regression model, bilirubin (hazard ratio [HR] 6.85, 95% confidence interval [CI] 1.73–27.1, p = 0.006), alkaline phosphatase (HR 5.46, 95% CI 1.32–22.6, p = 0.019), and histological stage (HR 4.87, 95% CI 1.16–20.5, p = 0.031) were found associated with LT‐free survival. For survival free from liver disease‐related death or LT, albumin (HR 7.72, 95% CI 1.48–40.4, p = 0.016) and bilirubin (HR 14.5, 95% CI 2.37–88.5, p = 0.004) were found significantly associated.ConclusionIn patients with PBC receiving combination therapy, prognostic variables were similar to those in patients receiving UDCA monotherapy. These results indicate the importance of diagnosing patients with PBC at an earlier stage because of the reduced effectiveness of BZF at advanced stages.
Direct contact with endothelial cells drives dental pulp stem cells toward smooth muscle cells differentiation via TGF‐β1 secretion
Authors: Zhang Yuchen , Zhong Jialin , Lin Shulan , Hu Mingxin , Liu Junqing , Kang Jun , Qi Yubingqing , Basabrain Mohammed S. , Zou Ting , Zhang Chengfei 
Published: June 2023

AbstractAimPrevascularization is vital to accelerate functional blood circulation establishment in transplanted engineered tissue constructs. Mesenchymal stem cells (MSCs) or mural cells could promote the survival of implanted endothelial cells (ECs) and enhance the stabilization of newly formed blood vessels. However, the dynamic cell–cell interactions between MSCs, mural cells and ECs in the angiogenic processes remain unclear. This study aimed to explore the interactions of human umbilical vein ECs (HUVECs) and dental pulp stem cells (DPSCs) in an in vitro cell coculture model.MethodologyHuman umbilical vascular ECs and DPSCs were directly cocultured or indirectly cocultured with transwell inserts in endothelial basal media‐2 (EBM‐2) supplemented with 5% FBS for 6 days. Expression of SMC‐specific markers in DPSCs monoculture and HUVEC+DPSC cocultures was assessed by western blot and immunofluorescence. Activin A and transforming growth factor‐beta 1 (TGF‐β1) in conditioned media (CM) of HUVECs monoculture (E‐CM), DPSCs monoculture (D‐CM) and HUVEC+DPSC cocultures (E+D‐CM) were analysed by enzyme‐linked immunosorbent assay. TGF‐β RI kinase inhibitor VI, SB431542, was used to block TGF‐β1/ALK5 signalling in DPSCs.ResultsThe expression of SMC‐specific markers, α‐SMA, SM22α and Calponin, were markedly increased in HUVEC+DPSC direct cocultures compared to that in DPSCs monoculture, while no differences were demonstrated between HUVEC+DPSC indirect cocultures and DPSCs monoculture. E+D‐CM significantly upregulated the expression of SMC‐specific markers in DPSCs compared to E‐CM and D‐CM. Activin A and TGF‐β1 were considerably higher in E+D‐CM than that in D‐CM, with upregulated Smad2 phosphorylation in HUVEC+DPSC cocultures. Treatment with activin A did not change the expression of SMC‐specific markers in DPSCs, while treatment with TGF‐β1 significantly enhanced these markers' expression in DPSCs. In addition, blocking TGF‐β1/ALK5 signalling inhibited the expression of α‐SMA, SM22α and Calponin in DPSCs.ConclusionsTGF‐β1 was responsible for DPSC differentiation into SMCs in HUVEC+DPSC cocultures, and TGF‐β1/ALK5 signalling pathway played a vital role in this process.
Oxidation‐induced crack‐healing behavior of SiC‐Al2O3‐TiB2 composites at 600°C–800°C
Authors: Cai Haopeng , Wei Yinglong , Wang Baoguo , Jiang Kun 
Published: June 2023

ABSTRACTIt is necessary to give self‐healing function to ceramic materials because of their notch sensitivity. In the past, studies on self‐healing ceramics have mainly focused on the high‐temperature stage, and less research has been done below 1000°C. In this study, SiC/Al2O3/TiB2 ceramic composites were prepared by spark plasma discharge sintering, and cracks were introduced on the surface of the polished specimens. Crack healing at 600°C–800°C was investigated, and the recovery of macroscopic bending strength and the change of microscopic crack morphology after heat treatment were used to evaluate the crack‐healing effect. It was found that the surface cracks of the material were completely filled and healed by oxidation products after heat treatment at 700°C for 60 min, and the highest healing efficiency exceeded 95% for both specimens with different crack lengths, and the main mechanism of crack by Si‐Al‐B‐Na‐Ca‐O type glass produced by the reaction of TiB2 and a small amount of SiC with oxygen to produce oxides and glass powder. Good healing effect and fast healing speed effectively improve the service life and reliability of ceramic materials, which has very far‐reaching significance for the practical application with ceramic materials.
Preparation and properties of lightweight, conformal, and load‐bearing TiC/Si3N4 absorbing composites by gel casting
Authors: Liang Guandong , Bi Jianqiang , Qiao Linjing , Yin Zhuangzhuang , Wang Shaoyin 
Published: June 2023

AbstractIn view of the lack of conformal, load‐bearing, light‐weight, and high temperature‐resistant integrated wave‐absorbing composites suitable for extremely complex conditions, the gel‐casting process was successfully applied to porous Si3N4 wave‐absorbing composites in this work. A universal low‐slurry for gel casting was prepared by using two dispersants acting together (tetramethylammonium hydroxide solution and sodium lauryl sulfate), which ensured the smooth completion of the gel casting process. Combining the thermogravimetric and differential thermal gravity curves of the composite green body, reasonable parameters of the rubber discharge process are given to avoid the problem of the green body swelling and cracking. The porous TiC/Si3N4 composites were successfully prepared by holding them at 1650°C for 3 h. The bending strength, density, minimum reflection loss, absorption bandwidth, and matched thickness in the P‐band of the composites with 30 wt.% TiC addition were 54.08 ± 3.02 MPa, 1.906 g/cm3, ‐37.75 dB, 1.9 GHz, and 4.1 mm, respectively. The electromagnetic wave loss mechanisms of the composites are a combination of conductivity loss, multiple reflections and scattering, interfacial polarization, and defect polarization.
Examining the context‐specific reasons and adoption of artificial intelligence‐based voice assistants: A behavioural reasoning theory approach
Authors: Anayat Shaista , Rasool Gowhar , Pathania Anjali 
Published: June 2023

AbstractAI‐based voice assistants are some of the most popular consumer products of artificial intelligence technology. This study investigates the influence of the reasoning process on overall consumer attitudes and adoption intentions towards AI‐based voice assistants. Behavioural reasoning theory was applied to hypothesize relationships between values, context‐specific reasons, attitudes, and adoption intention. Partial least squares structural equation modelling was used to test the research model and hypotheses using data from 550 potential consumers in India. This research suggests a positive influence of consumers' ‘reasons for’ on their attitude and adoption intentions towards AI‐based voice assistants, as well as a favourable impact of consumers' values on ‘reasons for’. This study discovered that ‘reasons for’ and ‘reasons against’ are not only opposites but are entirely autonomous and have an independent impact on consumers' attitudes towards AI‐based voice assistants. This research improved our understanding of AI‐based product adoption by identifying the paramount role of consumers' values and the ‘reasons for’ and ‘reasons against’ in shaping their attitudes and adoption intentions towards AI‐based voice assistants.
A hybrid graphite powder PFC@G for reserving higher carbon content of self‐lubrication graphite/SiC composites by RMI
Authors: Xue Rong , Wang Jiping , Chen Yiming , Zhang Zhejian , Xiao Zhichao , Xia Hongyan 
Published: June 2023

AbstractThe appropriate carbon content is indispensable for the application of self‐lubricating graphite/SiC composites. However, it is a big challenge to retain high carbon content in the reaction‐formed graphite/SiC composites because of drastic consumption of carbon by violent reaction with liquid silicon. In this study, a hybrid powder constructed by graphite particles (G) and glassy carbon derived from phenolic resin (PFC) was used as carbon sources, or PFC@G for short, to reserve higher content of carbon in the reaction‐formed composites. The weight ratio of phenolic resin to graphite particles was adjusted to obtain an appropriate PFC@G with dense microstructure and close‐grained surface. Compared with the graphite/SiC composites only using raw graphite particles as carbon sources, the carbon content of the composites fabricated with compact and large PFC@G has obviously increased (up to 172%). In particular, the carbon content of the composites fabricated with the weight ratio = 0.8 reached a high value of 44.26 vol.%, which exhibited outstanding self‐lubrication properties among the four kinds of the composites. The mechanism of reserving higher content of carbon in the graphite/SiC composites by constructing PFC@G is investigated, revealing that a continuous SiC layer formed on the surface of the larger size PFC@G and most closely packed graphite particles inside of PFC@G were insulate from liquid silicon by the layer.
Ethanol infusion in left atrial appendage vein for treating refractory left atrial appendage tachycardia
Authors: Squara Fabien , Scarlatti Didier , Baudouy Delphine , Bun Sok‐Sithikun , Moceri Pamela , Ferrari Emile 
Published: June 2023

AbstractIntroductionWe describe an unusual case of atrial tachycardia (AT) emanating from the left atrial appendage body (LAA), successfully treated by chemical ablation.MethodsA 66‐year‐old patient with cardiac amyloidosis and history of persistent atrial fibrillation ablation presented poorly tolerated AT with 1:1 atrioventricular nodal conduction at 135/min, despite amiodarone therapy. Three‐dimensional mapping suggested a reentrant AT from the anterior aspect of the left LAA.ResultsThe tachycardia could not be terminated with radiofrequency ablation. The LAA vein was then selectively catheterized and infused with Ethanol, resulting in immediate termination of tachycardia, without LAA isolation. No recurrence occurred at 12 months.ConclusionAtrial tachycardias emanating from the LAA that are resistant to radiofrequency ablation may respond to chemical ablation of the LAA vein.
Roles of GOBP1 in perception of host plant volatiles revealed by CRISPR/Cas9‐mediated mutagenesis in Spodoptera litura
Authors: Han Wei‐Kang , Wei Zhi‐Qiang , Yang Yi‐Lin , Liu Xiao‐Long , Yan Qi , Zhang Jin , Dong Shuang‐Lin 
Published: June 2023

AbstractThe general odorant‐binding proteins (GOBPs) in Lepidoptera form a distinct OBP subclass, which exclusively has two members (GOBP1 and GOBP2) in a single species. GOBPs are long thought to function in perception of plant odorants and recently in sex pheromones, but the in vivo evidence is rarely provided. Here, by using CRISPR/Cas9 technique, we demonstrated that GOBP1 in a noctuid moth Spodoptera litura is involved in perception of host plant volatiles but not of the female sex pheromone, and GOBP1 in females is less important than GOBP2 in host plant perception. First, the GOBP1 knockout strain (GOBP1−/−) of S. litura was obtained by CRISPR/Cas9 technique. Second, in the electroantennography (EAG) tests, GOBP1−/− females displayed significant reduction in responses to plant volatile farnesene, and leaf discs of the host plant cabbage (males only to high leaf doses), but GOBP1−/− adults did not show significant EAG reduction to the major sex pheromone component and two pheromone analogues. Third, compared with GOBP2−/− females, GOBP1−/− females were significantly lower in reduction (in relation to WT moths) of EAG response to host plant leaves. Our results provide in vivo evidence that GOBP1 is involved in perception of host plant volatiles but is less important than GOBP2 in S. litura.
Revelation of mindlines in the setting of crisis
Authors: Suh Edward Hyun , Wyer Peter C. 
Published: June 2023

AbstractDuring the devastating early months of the unfolding COVID‐19 pandemic in New York, healthcare systems and clinicians dynamically adapted to drastically changing everyday practice despite having little guidance from formal research evidence in the face of a novel virus. Through new, silo‐breaking networks of communication, clinical teams transformed and synthesized provisional recommendations, rudimentary published research findings and numerous other sources of knowledge to address the immediate patient care needs they faced during the pandemic surge. These experiences illustrated underlying social processes that are always at play as clinicians integrate information from various sources, including research and published guidelines, with their own tacit knowledge to develop shared yet personal approaches to practice. In this article, we provide a narrative account of personal experience during the COVID‐19 surge. We draw on the concept of mindlines as developed by Gabbay and Le May as a conceptual framework for interpreting that experience from the standpoint of how early information from research and guidelines was drawn on and transformed in the course of day‐to‐day struggle with the crisis in New York City emergency rooms. Finally, briefly referencing the challenges to conventional models of healthcare knowledge creation and translation through research and guideline production posed by COVID‐19 crisis, we offer a provisional perspective on current and future developments.
True molecular phylogenetic position of the cockroach gut commensal Lophomonas blattarum (Lophomonadida, Parabasalia)
Authors: Nguyen LeAnn , Taerum Stephen J. , Jasso‐Selles Daniel E. , Slamovits Claudio H. , Silberman Jeffrey D. , Gile Gillian H. 
Published: June 2023

AbstractLophomonas blattarum is a facultative commensal gut dweller of common pest cockroaches. Its cells are roughly spherical in shape with an apical tuft of ~50 flagella. Controversially, it has been implicated in human respiratory infections based on light microscopic observations of similarly shaped cells in sputum or bronchoalveolar lavage fluid. Here, we have sequenced the 18S rRNA gene of L. blattarum and its sole congener, Lophomonas striata, isolated from cockroaches. Both species branch in a fully supported clade with Trichonymphida, consistent with a previous study of L. striata, but not consistent with sequences from human samples attributed to L. blattarum.
FIGL1 coordinates with dosage‐sensitive BRCA2 in modulating meiotic recombination in maize
Authors: Zhang Ting , Zhao Shuang‐Hui , Wang Yan , He Yan 
Published: June 2023

AbstractMeiotic crossover (CO) formation between homologous chromosomes ensures their subsequent proper segregation and generates genetic diversity among offspring. In maize, however, the mechanisms that modulate CO formation remain poorly characterized. Here, we found that both maize BREAST CANCER SUSCEPTIBILITY PROTEIN 2 (BRCA2) and AAA‐ATPase FIDGETIN‐LIKE‐1 (FIGL1) act as positive factors of CO formation by controlling the assembly or/and stability of two conserved DNA recombinases RAD51 and DMC1 filaments. Our results revealed that ZmBRCA2 is not only involved in the repair of DNA double‐stranded breaks (DSBs), but also regulates CO formation in a dosage‐dependent manner. In addition, ZmFIGL1 interacts with RAD51 and DMC1, and Zmfigl1 mutants had a significantly reduced number of RAD51/DMC1 foci and COs. Further, simultaneous loss of ZmFIGL1 and ZmBRCA2 abolished RAD51/DMC1 foci and exacerbated meiotic defects compared with the single mutant Zmbrca2 or Zmfigl1. Together, our data demonstrate that ZmBRCA2 and ZmFIGL1 act coordinately to regulate the dynamics of RAD51/DMC1‐dependent DSB repair to promote CO formation in maize. This conclusion is surprisingly different from the antagonistic roles of BRCA2 and FIGL1 in Arabidopsis, implying that, although key factors that control CO formation are evolutionarily conserved, specific characteristics have been adopted in diverse plant species.
Dyadic process and dynamics of caregiving and receiving in suicide recovery among Filipino college‐aged students and their families
Authors: Tampus‐Siena Merimee , Alianan Arsenio S. 
Published: June 2023

AbstractWith the increasing incidence of suicidality among the youth, identifying effective care and support that family members provide is essential. Despite numerous studies on the link between suicide mitigation and caregiving, the dyadic process and dynamics of family members supporting youth at risk have been scarcely explored. This study utilizes grounded theory to explore the actions, interactions, and processes involved in caregiving and receiving between five pairs of Filipino family caregivers and college‐aged care receivers who recovered from suicidality. The study gave rise to a seven‐phase model that characterizes the dynamic dyadic interactions between the family caregiver and the youth care receiver. This is summarized in the acronym C2A2R2E, which means calling‐on, contemplating, accepting, allowing, responding, reciprocating, and empowering. This model highlights the processes and dynamics of care within families, which may be useful in paving the way for families and mental health professionals to foster more effective support in mitigating suicidality among youth at risk.
The Effect of Mindfulness‐Based Sexual Counseling on Sexual Distress, Attitude Toward Sexuality, and Body Image Concerns in Pregnant Women: A Randomized Controlled Trial
Authors: Cengizhan Sıdıka Özlem , Uçar Tuba 
Published: June 2023

IntroductionSexual distress during pregnancy can cause a negative attitude toward sexuality during pregnancy, and this can be seen especially in conjunction with body image concerns. This study was conducted to determine the effects of mindfulness‐based sexual counseling (MBSC) on sexual distress, attitudes toward sexuality, and body image concerns in pregnant women.MethodsA randomized controlled trial was conducted in a sample of women who experienced sexual distress presenting to a Healthy Living Center in eastern Turkey. Women (N = 134) were randomly assigned to receive a 4‐week, 8‐session counseling program based on mindfulness (experimental group; n = 67) or treatment as usual (control group; n = 67). The primary outcome of the study, sexual distress, was assessed using the Female Sexual Distress Scale‐Revised. Secondary outcomes included attitude toward sexuality, assessed using the Attitude Scale toward Sexuality during Pregnancy, and body image concerns, using the Body Image Concerns during Pregnancy Scale. Outcomes were compared postintervention, correcting for baseline using analysis of covariance. The study was registered with ClinicalTrials.gov (NCT04900194).ResultsMean scores for sexual distress (7.69 vs 17.36; P < .001) and body image concerns (57.76 vs 73.88; P < .001) decreased significantly in the mindfulness group compared with the control group. Similarly, mean scores for attitudes toward sexuality significantly improved in the mindfulness group compared with the control group (133.52 vs 105.78; P < .05).DiscussionMBSC is a promising strategy to help women experiencing sexual distress during pregnancy to reduce their levels of sexual distress, raise their positive attitudes toward sexuality, and lower their body image concerns. Larger clinical trials of MBSC are recommended to support introduction of MBSC into clinical practice.