bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interleukin‐37 inhibits desmoglein‐3 endocytosis and keratinocyte dissociation via upregulation of Caveolin‐1 and inhibition of the STAT3 pathway
Authors: Liang Junqin , Hu Fengxia , Mao Lidan , Qiu Yun , Jiang Fanhe , Wang Qian , Abulikemu Kailibinuer , Hong Yongzhen , Ge Xinyu , Kang Xiaojing 
Published: June 2023

AbstractBackgroundPemphigus vulgaris (PV) is a potentially fatal autoimmune bullous disease primarily caused by acantholysis of keratinocytes attributed to pathogenic desmoglein‐3 (Dsg3) autoantibodies. Interleukin‐37 (IL‐37) reportedly plays important roles in a variety of autoimmune diseases, but its role in PV is not clear.ObjectivesTo investigate whether IL‐37 plays a role in the occurrence and progression of PV.MethodsHaCaT keratinocytes were stimulated with anti‐Dsg3 antibody to establish an in vitro PV model, which was defined as anti‐Dsg3 group. Cells incubated with medium without anti‐Dsg3 treatment were used as control. IL‐37 was cultured with these cells infected with or without lentiviral vector shRNA‐Caveolin‐1 (sh‐Cav‐1‐LV). Cell dissociation assay and immunocytofluorescence were performed to assess keratinocyte dissociation, keratin retraction and Dsg3 endocytosis. Real‐time PCR was used to detect the mRNA level of Cav‐1, and western blot was used to determine the protein expression of Cav‐1, Dsg3, STAT3 and phosphorylated‐STAT3 (p‐STAT3).ResultsThe anti‐Dsg3 group showed more cell debris, increased keratin retraction, increased Dsg3 endocytosis, reduced Cav‐1 expression and co‐localization than the control group, while IL‐37 treatment neutralized all of these changes. Interestingly, Cav‐1 knockdown supressed the inhibitory effect of IL‐37 on keratinocyte dissociation and Dsg3 internalization. The protein expression of p‐STAT3 was increased in keratinocytes of the PV model but decreased by IL‐37. Re‐activation of the STAT3 pathway by colivelin supressed the inhibitory effect of IL‐37 on keratinocyte dissociation and Dsg3 internalization, along with upregulation of Cav‐1 and Dsg3.ConclusionsIL‐37 inhibited keratinocyte dissociation and Dsg3 endocytosis in an in vitro PV model through the upregulating Cav‐1 and inhibiting STAT3 pathway.
Characterization of entomopathogenic fungi from invasive fall armyworm in China and their risk to native pests
Authors: Sun Shuai , Zhang Zhichun , Niu Hongtao , Zhao Dongxiao , Liu Xiangdong , Guo Huifang 
Published: June 2023

AbstractThe role of pathogens in the successful invasion of pests has received increasing attention. Previous hypotheses on parasite‐related invasion mainly focus on the lack of parasites against invasive pests or the introduction of parasites with a higher risk to native pests. Fall armyworm (FAW), Spodoptera frugiperda (J.E. Smith), is a new invasive pest in China. Here, we investigated pathogen infection in eight natural populations of FAW in China, isolated and characterised the pathogens, and then evaluated the infection risk of the pathogens to native pests. The pathogen infection frequencies in FAW were very low (0.32%); only two individuals were found to have typical symptoms of fungal infection, and the fungi were identified as Beauveria bassiana and Metarhizium rileyi. Internal transcribed spacer sequence‐based analysis showed that among 44 B. bassiana isolates worldwide, the SFJS01 isolate was genetically different from only 3 isolates. Among all 13 isolates of M. rileyi from FAW, including the SFGX01 isolate, there was no significant differentiation. Comparison of the mortality caused by B. bassiana SFJS01 or M. rileyi SFGX01 against S. frugiperda, Spodoptera litura, Bemisia tabaci, Laodelphax striatellus and Nilaparvata lugens showed that the new isolates all had the highest virulence to S. frugiperda and the lowest virulence to S. litura, a native pest closely related to FAW. The findings indicated that pathogens isolated from FAW did not pose a high risk to native pests and that they did not play a key role in the successful invasion of the FAW in China.
Do Economic Sanctions Work? Evidence from the Russia‐Ukraine Conflict
Authors: Gaur Ajai , Settles Alexander , Väätänen Juha 
Published: June 2023

AbstractThis study examines the impact of sanctions on Russian firms and the strategies these firms adopt to counter the effects of targeted sanctions. We utilize institutional theory to explain how firms shape their strategic responses as they balance the institutional pressures from their home environment vis‐à‐vis sanctioning countries. We gather longitudinal data on Russian firms that faced foreign sanctions from the start of the invasion of Crimea in 2014 until 2020. Our empirical analyses indicate that sanctions do not have a persistent negative effect on the economic performance of Russian firms. We discuss the empirical findings with the help of a series of illustrative examples of specific actions that Russian firms undertook in response to the sanctions. We conclude that while targeted sanctions create symbolic meaning in foreign relations and create financial friction for targeted firms, firms use a variety of adaptation strategies that negate the economic impact of these sanctions.
Identifying temporal drivers of product acceptance and rejection across sips during whole product consumption
Authors: Weerawarna N. R. P. Maheeka , Godfrey A. Jonathan R. , Ellis Ashling , Hort Joanne 
Published: June 2023

AbstractMeasuring emotional response gives insights into consumer product experiences beyond liking. However, existing research rarely considers that emotional and hedonic responses can change during consumption of a whole portion. This research considered how well a combined multiple‐sip temporal check‐all‐that‐apply approach captured temporal drivers of product acceptance and rejection. Consumers (n = 104) profiled temporal sensory, liking and emotional responses to three milkshakes. Associations in temporal sensory, liking and emotional response citation pattern across multiple sips were investigated using generalized linear models, analysis of deviance and Pearson's chi‐square test. Differences in the temporal dynamics of sensory, liking and emotional responses and associations between temporal sensory and affective responses were identified highlighting liking and emotional experience were related to the evolution of sensory attributes over time. Notably, sensory associations with emotional responses, including “bored,” “relaxed,” and “satisfied,” were better at identifying temporal drivers of acceptance/rejection more than associations to level of liking.Practical ApplicationsThe research demonstrated that a combined multiple‐sip temporal check‐all‐that‐apply (TCATA) approach, representing whole product consumption, is an effective approach to gain deeper insights into the sensory drivers of consumer affective response. However, the applicability of analyzing within‐sip variations in perception, and potential to use check all that apply by sip as opposed to TCATA needs to be considered on a product category basis.
The Longest Known Follow‐Up of Vitallium Mold Arthroplasty in China: A Case Report and Literature Review
Authors: Leng Junsheng , Peng Huiming , Feng Bin , Weng Xisheng 
Published: June 2023

BackgroundBefore the advent of total hip arthroplasty, Vitallium mold arthroplasty had been widely performed. We present a case with a 42‐year follow‐up after Vitallium mold arthroplasty. To our knowledge, this case represents the longest known follow‐up of Vitallium mold arthroplasty in China.Case presentationThis was a 59‐year‐old male. He underwent Vitallium mold arthroplasty of the left hip 42 years ago because of osteonecrosis of the femoral head. He developed left hip pain 3 months ago and underwent total hip revision surgery. There was some clear synovial fluid in the hip joint. The mold was loosened entirely and taken out effortlessly. Gram‐positive cocci could be observed occasionally in the synovial fluid smear, while the synovial fluid culture was negative. The inflammatory markers elevated perioperatively, and prophylactic cefuroxime and vancomycin were utilized successively. All elevated inflammatory markers fell since postoperative day 5, and there was no other sign of infection. The pain and function of the hip joint improved significantly after surgery.ConclusionsAlthough Vitallium mold arthroplasty was inferior to total hip arthroplasty in survival rate and functional outcome, it did provide an excellent long‐term function of the hip joint.
Electrographic flow mapping guided catheter ablation offers advantages for patients with persistent atrial fibrillation
Authors: Gagyi Rita B. , Bhagwandien Rohit E. , Yap Sing‐Chien , Hoogendijk Mark , Wijchers Sip , Szili‐Torok Tamas 
Published: June 2023

AbstractBackgroundCatheter ablation (CA) remains challenging due to suboptimal success rates in persistent atrial fibrillation (AF). Existing mapping technologies cannot reliably distinguish sources in this patient population. Recently, the novel electrographic flow (EGF) mapping system was developed using a modified Horn‐Schunk optical flow algorithm to detect and quantify patterns of electrical wavefront propagation in the atria.ObjectivesTo test the hypothesis that targeted source ablation based on EGF mapping is superior to empiric AF ablation.MethodsWe included all consecutive patients undergoing EGF guided ablation for persistent AF. All patients underwent pulmonary vein isolation (PVI) and were treated with the same EAM system (CARTO). The outcome of PVI+EGF guided CA was compared with data of PVI‐only procedures (PVI‐only group) and PVI plus additional empiric adjunctive linear and substrate ablations (PVI+LINES group). 12‐months outcome as freedom from AF and atrial tachycardia/flutter (AT/AFL), procedural safety and efficiency characterized by procedure duration, fluoroscopy use, radiofrequency applications and duration, were analyzed. Both intention‐to‐treat and per protocol analysis were conducted.ResultsA total number of 70 patients (39 in PVI+EGF, 16 in PVI‐only and 15 patients in PVI+LINES group) were enrolled. Intention‐to‐treat analysis showed fewer AF recurrences in PVI+EGF as compared with the PVI‐only or PVI+LINES groups at 12 months (25.6% vs. 62.5% vs. 53.3%, p = .02). There were no differences in AT/AFL recurrence (17.9% vs. 37.5% vs. 20.0%, p = .37). Procedure times were longer in PVI+EGF group (p < .01), and there were no differences in fluoroscopy use (p = .67).ConclusionOur data suggest that patients treated with EGF‐guided CA developed fewer AF recurrences. Although the procedure times are longer, it seems to be safe and offers a more targeted, patient‐specific ablation strategy beyond PVI than adjunctive empiric lines and substrate ablation in this complex group of patients.
Cranial endocast of Anagale gobiensis (Anagalidae) and its implications for early brain evolution in Euarchontoglires
Authors: López‐Torres Sergi , Bertrand Ornella C. , Lang Madlen M. , Fostowicz‐Frelik Łucja , Silcox Mary T. , Meng Jin 
Published: June 2023

AbstractAnagalids are an extinct group of primitive mammals from the Asian Palaeogene thought to be possible basal members of Glires. Anagalid material is rare, with only a handful of crania known. Here we describe the first virtual endocast of an anagalid, based on the holotype of Anagale gobiensis (AMNH 26079; late Eocene, China), which allows for comparison with published endocasts from fossil members of modern euarchontogliran lineages (i.e. primates, rodents, lagomorphs). The endocast displays traits often observed in fossorial mammals, such as relatively small petrosal lobules and a low neocortical ratio, which would be consistent with previous inferences about use of subterranean food sources based on heavy dental wear. In fact, Anagale gobiensis has the lowest neocortical ratio yet recorded for a euarchontogliran. This species was olfaction‐driven, based on the relatively large olfactory bulbs and laterally expansive palaeocortex. The endocast supports previous inferences that relatively large olfactory bulbs, partial midbrain exposure and low encephalization quotient are ancestral for Euarchontoglires, although the likely fossorial adaptations of Anagale gobiensis may also partly explain these traits. While Anagale gobiensis is a primitive mammal in many aspects, some of its derived endocranial traits point towards a new, different trajectory of brain evolution within Euarchontoglires.
Transient abdominal telangiectasia of the newborn: Four new cases with abdominal distension
Authors: Cutrone Mario , Van Gysel Dirk 
Published: June 2023

AbstractTransient abdominal telangiectasia of the newborn (TATN) is a recently described entity. The majority of cases had no specific clinical context or trigger identified, but a minority occurred in the clinical context of transient increased intraabdominal pressure. We report four additional cases of TATN, all in the presence of transient abdominal distension, further supporting the causative relationship of abdominal distension to TATN.
Reducing subgroup differences in personnel selection through the application of machine learning
Authors: Zhang Nan , Wang Mo , Xu Heng , Koenig Nick , Hickman Louis , Kuruzovich Jason , Ng Vincent , Arhin Kofi , Wilson Danielle , Song Q. Chelsea , Tang Chen , Alexander Leo , Kim Yesuel 
Published: June 2023

AbstractResearchers have investigated whether machine learning (ML) may be able to resolve one of the most fundamental concerns in personnel selection, which is by helping reduce the subgroup differences (and resulting adverse impact) by race and gender in selection procedure scores. This article presents three such investigations. The findings show that the growing practice of making statistical adjustments to (nonlinear) ML algorithms to reduce subgroup differences must create predictive bias (differential prediction) as a mathematical certainty. This may reduce validity and inadvertently penalize high‐scoring racial minorities. Similarly, one approach that adjusts the ML input data only slightly reduces the subgroup differences but at the cost of slightly reduced model accuracy. Other emerging tactics involve weighting predictors to balance or find a compromise between the competing goals of reducing subgroup differences while maintaining validity, but they have been limited to two outcomes. The third investigation extends this to three outcomes (e.g., validity, subgroup differences, and cost) and presents an online tool. Collectively, the studies in this article illustrate that ML is unlikely to be able to resolve the issue of adverse impact, but it may assist in finding incremental improvements.
Damage on grapevine cv. Niagara Rosada leaves caused by the combined effect of temperature and Asian grapevine leaf rust (Neophysopella tropicalis)
Authors: Rasera Júlia B. , Appezzato‐da‐Glória Beatriz , Ribeiro Rafael V. , Nogueira‐Júnior Antônio F. , Amorim Lilian 
Published: June 2023

AbstractAsian grapevine leaf rust (AGLR), caused by Neophysopella tropicalis, is a problem for viticulture, especially in latitudes lower than 25° S, which include the most significant production regions in Brazil. Climate change has raised new concerns in agriculture as temperature can affect the resistance of plants to pathogens. With the aim of understanding how air temperature rise affects the AGLR pathosystem, measurements of leaf gas exchange and epidemiological and histopathological analyses were carried out on control and inoculated leaves of Vitis labrusca ‘Niagara Rosada’ grown at 25°C and 30°C. The lesion density and rust severity were higher at 25°C than 30°C, and the ratio between adaxial surface necrosis and the abaxial surface area occupied by pustules was >1 only at 30°C, presenting a necrosis not associated to the pathogen lesion. In fact, leaf necrosis was identified on control plants kept at 30°C and associated with gerontoplasts, representing accelerated leaf senescence. The AGLR pathogen reduced gas exchange and photosystem II activities at 25°C, with no difference between control and inoculated plants at 30°C. Our results indicate that AGLR is sensitive to increasing air temperature. However, the accelerated leaf senescence caused by the combination of N. tropicalis infection and temperature on Niagara Rosada can lead to high leaf damage.
An R2R3 MYB transcription factor PsFLP regulates the symmetric division of guard mother cells during stomatal development in Pisum sativum
Authors: Ning Conghui , Yang Yating , Chen Qiyi , Zhao Weiyue , Zhou Xuan , He Liangliang , Li Laigeng , Zong Dan , Chen Jianghua 
Published: June 2023

AbstractMYB transcriptional regulators belong to one of the most significant transcription factors families in plants, among which R2R3‐MYB transcription factors are involved in plant growth and development, hormone signal transduction, and stress response. Two R2R3‐MYB transcription factors, FLP and its paralogous AtMYB88, redundantly regulate the symmetrical division of guard mother cells (GMCs), and abiotic stress response in Arabidopsis thaliana. Only one orthologue gene of FLP was identified in pea (Pisum sativum FLP; PsFLP). In this study, we explored the gene function of PsFLP by virus‐induced gene silencing (VIGS) technology. The phenotypic analysis displayed that the silencing of PsFLP expression led to the abnormal development of stomata and the emergence of multiple guard cells tightly united. In addition, the abnormal stomata of flp could be fully rescued by PsFLP driven by the FLP promoter. In conclusion, the results showed that PsFLP plays a conservative negative role in regulating the symmetric division of GMC during stomatal development. Based on real‐time quantitative PCR, the relative expressions of AAO3, NCED3, and SnRK2.3 significantly increased in the flp pFLP::PsFLP plants compared to mutant, indicating that PsFLP might be involved in drought stress response. Thus, PsFLP regulates the genes related to cell cycle division during the stomatal development of peas and participates in response to drought stress. The study provides a basis for further research on its function and application in leguminous crop breeding.
A review on the effect of light–thermal–humidity environment in sow houses on sow reproduction and welfare
Authors: Ma Hongqiang , Xie Yue , Li Anying , Zhang Ting , Liu Yu , Luo Xinmei 
Published: June 2023

AbstractThe environment in sow houses is the key to restrict sow production due to its significant effect on sow growth and reproduction. In this article, the effect of light, thermal and light–thermal–humidity environment in sow houses is systematically reviewed for sow reproduction and welfare according to the existing literature. The results show the optimal ambient temperature range for sows is approximately 16–22°C, as well as the lowest and highest critical temperature are 16 and 27°C respectively. Meanwhile, the increase of relative humidity from 50% to 70% is equivalent to the increase of effective temperature by 0.9°C in sow houses. In addition, the evaluation indexes are summarized to the future research direction is proposed according to the reviewed results. It can be concluded that the current research mainly focuses on the effect mechanism of light–thermal–humidity environment on sow growth and reproductive performance, as well as the optimal regulation range of light–thermal–humidity environment. In particular, it is a popular topic to further study the effect of light–thermal–humidity environment on the genetic material of sows, as well as metabolic parameters and body composition of their offspring. The above conclusions can contribute to guiding the regulation of light–thermal–humidity environment in sow houses and improving the sow welfare.
Intimate mobilities—International (transnational) marriage and migration: Japanese marriage migrants floating between Japan and Korea
Authors: Takeda Atsushi 
Published: June 2023

AbstractIn the past decade, intense mobility within Asia has led to increased international marriage (kokusai kekkon) in the region. A growing number of scholars have explored this phenomenon—called the intimate part of Asia—with a focus on foreign brides from emerging economies. Concerning international marriage between Japanese and Koreans, most research focuses on the Korean wives of Japanese husbands who reside in Japan, and little research has been conducted on the Japanese wives of Korean husbands. In this study, the postmigration experiences of Japanese marriage migrant women in South Korea are explored. Semistructured interviews were conducted in Korea with 13 participants. Drawing on the interview data, this article elucidates the trajectories of Japanese marriage migrants, focusing on subjective elements. The participants' accounts demonstrate that their experiences were intertwined with the media, politics, gender roles, parenting ideologies, and family relations. Their various emotional responses underline the ways such factors have shaped their lives.
Imaging of post‐collisional deformations on the NE Tisza continental unit using ambient seismic noise: A case study from the Țicău area, Romania
Authors: Panea Ionelia , Draganov Deyan , Bouaru Catalin Florin , Munteanu Ioan 
Published: June 2023

AbstractThe Ţicău area (NW Romania) is part of the collisional zone between the Tisza and Dacia mega‐units. Imaging of Ţicău area's subsurface geological structure will contribute to the understanding of the processes, which controlled its tectonic evolution. Analysis of outcrops provides accurate information for the building of kinematic sections used to explain the small‐scale deformations of sedimentary formations, such as those developed south of the Ţicău mountains. Imaging of large‐scale deformations requires analysis of data recorded and/or measured over a wider area. We use Seismic Interferometry by cross‐correlation on ambient noise recorded along with a line located north of the Ţicău mountains. The passive seismic section obtained after virtual body‐wave reflections processing displays folded and faulted Paleogene formations, which are in good agreement with the observations on outcrops found to the south of the Ţicău mountains. The active‐source data recorded along with the same line are too noisy for interpretation.
Diorama—An Opening for Addressing the Global Challenges
Authors: Stenseke Marie 
Published: June 2023

AbstractThroughout his academic life, Hägerstrand showed a genuine concern for global environmental challenges. In order to come to grips with detrimental environmental trends, he was seeking ways to better understand humanity's role in changing the face of the earth. The article Diorama, Path and Project marks the intensification of Hägerstrand's ambitions to draw a holistic framework for the integrated relations between humans, human society and the physical environment. Here, I reflect on Hägerstrand's thinking over the years since 1982, and how that relates to contemporary efforts to address sustainability challenges, from three overlapping questions: how to address complexity?; how to comprehend the materiality of humans?; and how to meet across disciplines?