bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of Ramadan fasting on mental health and some hormonal levels in healthy males
Authors: Akan Mustafa , Unal Suheyla , Gonenir Erbay Lale , Taskapan Mehmet Cagatay 
Published: February 2023

Abstract
Background
Millions of Muslims around the world fast during the holy month of Ramadan as a requirement of their religion Islam. Studies have reported varying effects of Ramadan fasting on mental health and various hormones. This study aimed to examine the effects of Ramadan fasting on mental health and plasma Leptin, Ghrelin, Neuropeptide Y (NPY), Growth Hormone levels in healthy individuals, and to evaluate the possible relationship between their hormone values and scale scores. Male healthcare professionals working at a university hospital without any psychiatric disease were included in the study. In the last week before Ramadan and in the first week after Ramadan, participants’ blood samples were taken at 8.00 in the morning after 12 h of fasting, taking into account the release pattern and pulsatile release of these hormones in order to measure plasma Leptin, Ghrelin, NPY and Growth Hormone levels. Simultaneously, a sociodemographic data form, the Brief Symptom Inventory (BSI) and the Scale of Dimensions of Interpersonal Relationships were applied to participants.

Results
The sample of the study included a total of 40 healthcare professionals. Participants’ BSI interpersonal sensitivity and phobic anxiety subscales scores and their general severity and positive symptom distress index scores decreased significantly after Ramadan compared to those measured before Ramadan. (p < 0.001, p = 0.020, p = 0.042, p = 0.006 respectively). Also participants’ ghrelin levels increased significantly after Ramadan compared to those measured before Ramadan (p < 0.001).

Conclusions
The effects of Ramadan fasting on mental health may be mediated by some psychoneuroendocrine mechanisms. In order to elucidate these mechanisms that mediate the effect of Ramadan fasting on mental health, there is a need for better-structured studies with larger samples and more variables.
Cerebral organoids in primary progressive multiple sclerosis reveal stem cell and oligodendrocyte differentiation defect
Authors: Daviaud Nicolas , Chen Eric , Edwards Tara , Sadiq Saud A. 
Published: February 2023

ABSTRACT
Multiple sclerosis (MS) is an auto-immune inflammatory disorder affecting the central nervous system. The cause of the disease is unknown but both genetic and environmental factors are implicated in the pathogenesis. We derived cerebral organoids from induced pluripotent stem cells (iPSC) of healthy control subjects as well as from primary progressive MS (PPMS), secondary progressive MS (SPMS) and relapsing remitting MS (RRMS) patients to better understand the pathologic basis of the varied clinical phenotypic expressions of MS. In MS organoids, most notably in PPMS, we observed a decrease of proliferation marker Ki67 and a reduction of the SOX2+ stem cell pool associated with an increased expression of neuronal markers CTIP2 and TBR1 as well as a strong decrease of oligodendrocyte differentiation. This dysregulation of the stem cell pool is associated with a decreased expression of the cell cycle inhibitor p21. Our findings show that the genetic background of a patient can directly alter stem cell function, provides new insights on the innate cellular dysregulation in MS and identifies p21 pathway as a new potential target for therapeutic strategies in MS.
MR angiography facilitates the differentiation of aneurysmal from unicameral bone cysts
Authors: Gruenewald Leon David , Koch Vitali , Gruber-Rouh Tatjana , Thalhammer Axel , Frank Johannes , Marzi Ingo , Booz Christian , Yel Ibrahim , Mahmoudi Scherwin , Bernatz Simon , Laudenberger Isabella , Lingwal Neelam , Vogl Thomas J , Eichler Katrin 
Published: February 2023

Objectives: The objective of this work was to evaluate the incremental value of MR angiography over plain radiographs and MRI for the differentiation of aneurysmal bone cysts (ABCs) from unicameral bone cysts (UBCs). Methods: Thirty-six juvenile patients with histologically secured primary ABCs or UBCs were included in this retrospective study. Two radiologists assessed all obtained images in a blinded fashion using a catalog of previously suggested imaging findings. A second readout with supplementary MR angiography images was performed after 8 weeks to prevent observer recall bias. Diagnostic accuracy parameters were calculated for individual imaging findings, and overall diagnostic accuracy and diagnostic confidence were assessed for all readouts. Receiver operating characteristic (ROC) curve comparison was used to determine the incremental value of MR angiography. Results: Of 16 imaging features, only abnormal vascularization in MR angiography provided sufficient diagnostic accuracy for the identification of ABCs. Other imaging features such as fluid–fluid levels and internal septations were insufficient for the differentiation of UBCs from ABCs. Availability of MR angiography images significantly increased diagnostic accuracy (94.4 vs 75.0% and 83.3 vs 69.4%, respectively, p < 0.05) and diagnostic confidence (4.5 vs 3.7, p < 0.05) of reading radiologists. Conclusion: The presence of arterial feeders in MR angiography can accurately discriminate primary ABCs from UBCs and increases the diagnostic accuracy and diagnostic confidence of reporting radiologists. Advances in knowledge: Radiographic differentiation of cystic bone lesions such as ABCs and UBCs remains challenging. We demonstrate that MR angiography provides incremental value and suggest inclusion in standard examination protocols.
Anthropometric indicators for obesity and its relationship with depressive symptoms: analysis of a Peruvian national survey
Authors: Vera-Ponce Victor Juan , Torres-Malca Jenny Raquel , Guerra Valencia Jamee , Espinoza Rojas Rubén , Zuzunaga-Montoya Fiorella E. , Zeñas-Trujillo Gianella Zulema , Cruz-Ausejo Liliana , De La Cruz-Vargas Jhony A. 
Published: February 2023

Background: The association between obesity and depression has been frequently reported. However, it still remains unclear which anthropometric indicators for obesity could be the best measure to explain its linkage with depressive symptoms. Methods: This is a cross-sectional analytical study. Secondary data was analyzed using information from the Demographic and Health Survey of Peru (ENDES in Spanish). Data from the years 2018 to 2021 were reviewed. The outcome of interest was the presence of depressive symptoms, assessed with the Patient Health Questionnaire-9 (PHQ-9). The exposure variable was the presence of obesity, which was evaluated by body mass index (BMI) and abdominal circumference. Crude and adjusted odds ratios (cOR and aOR) were calculated using logistic regression. Both prevalence and association measures were presented with 95% confidence intervals (95% CI). Results: A total of 141,134 subjects were included in the study. Depression was present in 2.51% (95% CI 2.38–2.65). Obesity according to BMI was present in 25.42% (95% CI 24.97–25.88), while abdominal obesity was shown in 41.67% (95% CI 41.19–42.15). In the multivariate analysis, a statistically significant association was found in regard to symptoms of depression in patients with abdominal obesity (aOR: 1.13; 95% CI 1.03–1.24), while no association was found with obesity according to BMI. Conclusions: Abdominal circumference could be a better anthropometric measure than BMI to evaluate the association between obesity and depressive symptoms in the Peruvian population.
Goji berry (Lycium barbarum) inhibits the proliferation, adhesion, and migration of oral cancer cells by inhibiting the ERK, AKT, and CyclinD cell signaling pathways: an in-vitro study
Authors: Sanghavi Amee , Srivatsa Ananth , Adiga Divya , Chopra Aditi , Lobo Richard , Kabekkodu Shama Prasada , Gadag Shivaprasada , Nayak Usha , Sivaraman Karthik , Shah Ashmeet 
Published: February 2023

Background: Lycium barbarum (L. barbarum), popularly referred to as Goji berry, is a promising herb known for its powerful anti-antioxidant, antibacterial, and anti-inflammatory properties. It is used in traditional Chinese medicine for treating inflammatory and infectious diseases. It has also shown good anti-cancer properties and has been tested against liver, colon, prostate, breast, and cervical cancers. However, no study has yet evaluated the role of goji berries against oral cancer. Hence, the present paper aims to evaluate the anticancer properties of L. barbarum against oral squamous cell carcinoma. Method: Ethanolic extract of L. barbarum (EELB) was tested for its anticancer properties by performing the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay, colony formation, cell proliferation, and scratch wound test. The impact of EELB on the signaling transduction pathways of Extracellular signal-regulated kinase (ERK1/2), protein kinase (AKT1), cyclin D1 and epithelial-mesenchymal transition (EMT) was also assessed by western blot. Results: The results showed that EELB can impede CAL-27 cell growth, proliferation and migration in-vitro. It even reduced the phosphorylation of ERK1/2 and AKT1 with concomitant downregulation of cyclin D1 (CCND1), cadherin 2 (CDH2), and vimentin (VIM) and upregulation of cadherin 1 (CDH1) expression suggesting its anti-proliferative and anti-EMT effects in oral cancer. Conclusion: Goji berry has good antiproliferative and anti-invasive properties. It affects potential EMT markers and signaling transduction pathways involved in oral cancers. Hence goji berry can be tried as a potential anticancer agent to manage oral squamous cell carcinoma.
Qualitative data sharing practices in clinical trials in the UK and Ireland: towards the production of good practice guidance
Authors: McCarthy Megan , Gillies Katie , Rousseau Nikki , Wade Julia , Gamble Carrol , Toomey Elaine , Matvienko-Sikar Karen , Sydes Matthew , Dowling Maura , Bryant Val , Biesty Linda , Houghton Catherine 
Published: February 2023

Background: Data sharing enables researchers to conduct novel research with previously collected datasets, thus maximising scientific findings and cost effectiveness, and reducing research waste. The value of sharing, even de-identified, quantitative data from clinical trials is well recognised with a moderated access approach recommended. While substantial challenges to sharing quantitative data remain, there are additional challenges for sharing qualitative data in trials. Incorporating the necessary information about how qualitative data will be shared into already complex trial recruitment and consent processes proves challenging. The aim of this study was to explore whether and how trial teams share qualitative data collected as part of the design, conduct, analysis, or delivery of clinical trials. Methods: Phase 1 involved semi-structured, in-depth qualitative interviews and focus groups with key trial stakeholder groups including trial managers and clinical trialists (n=3), qualitative researchers in trials (n=9), members of research funding bodies (n=2) and trial participants (n=1). Data were analysed using thematic analysis. In Phase 2, we conducted a content analysis of 16 participant information leaflets (PIL) and consent forms (CF) for trials that collected qualitative data. Results: Three key themes were identified from our Phase 1 findings: ‘Understanding and experiences of the potential benefits of sharing qualitative data from trials’, ‘Concerns about qualitative data sharing’, and ‘Future guidance and funding’. In phase 2, the PILs and CFs received revealed that the benefits of data sharing for participants were only explained in two of the study documents. Conclusions: The value of sharing qualitative data was acknowledged, but there are many uncertainties as to how, when, and where to share this data. In addition, there were ethical concerns in relation to the consent process required for qualitative data sharing in trials. This study provides insight into the existing practice of qualitative data sharing in trials.
Transcranial direct current stimulation with functional magnetic resonance imaging: a detailed validation and operational guide
Authors: Nardo Davide , Creasey Megan , Negus Clive , Pappa Katerina , Aghaeifar Ali , Reid Alphonso , Josephs Oliver , Callaghan Martina F. , Crinion Jenny T. 
Published: February 2023

Introduction: Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation technique used to modulate human brain and behavioural function in both research and clinical interventions. The combination of functional magnetic resonance imaging (fMRI) with tDCS enables researchers to directly test causal contributions of stimulated brain regions, answering questions about the physiology and neural mechanisms underlying behaviour. Despite the promise of the technique, advances have been hampered by technical challenges and methodological variability between studies, confounding comparability/replicability. Methods: Here tDCS-fMRI at 3T was developed for a series of experiments investigating language recovery after stroke. To validate the method, one healthy volunteer completed an fMRI paradigm with three conditions: No-tDCS, Sham-tDCS, Anodal-tDCS. MR data were analysed with region-of-interest (ROI) analyses of the electrodes and reference site. Results: Quality assessment indicated no visible signal dropouts or distortions in the brain introduced by the tDCS equipment. After modelling scanner drift, motion-related variance, and temporal autocorrelation, we found that functional MR sensitivity was not degraded or adversely affected by the tDCS set-up and stimulation protocol across conditions in grey matter and in the three ROIs. Discussion: Key safety factors and risk mitigation strategies that must be taken into consideration when integrating tDCS into an fMRI environment are outlined. To obtain reliable results, we provide practical solutions to technical challenges and complications of the method. It is hoped that sharing these data and Standard Operation Procedure (SOP) will promote methodological replication in future studies, enhancing the quality of tDCS-fMRI application, and improve the reliability of scientific results in this field. Conclusions: Our method and data provide a technically safe, reliable tDCS-fMRI procedure to obtain high quality MR data. The detailed framework of the SOP systematically reports the technical and procedural elements of our tDCS-fMRI approach, which can be adopted and prove useful in future studies.
PRODUCTION RISKS IN THE PERSONNEL MANAGEMENT SYSTEM: WESTERN EXPERIENCE
Authors: Minchenkova O. , Minchenkova A. , Fedorova N. , Fedorov A. 
Published: February 2023

The growing role of organizations in promoting risk management in production indicates their desire to improve the working conditions of personnel and control all risks. Personnel costs represent investments, not costs, that facilitate management in the direction of preventing risks associated with the business. This includes the definition of responsibilities and organizational structure, planning activities, responsibilities, practices, procedures and resources for the development, implementation, implementation, revision and maintenance of policies to prevent industrial risks.
Improving the working conditions of personnel and environmental protection should be considered as important practical goals that can be achieved through measures such as risk factors control; adaptation of equipment and labor tools appropriate to human capabilities; changes in the organization, maintenance and control of labor; environmental monitoring and education. Risk assessment should be a dynamic process. For this, each enterprise, in accordance with the legislation, should develop a system for preventing industrial risks, the purpose of which is to promote the safety and health of employees by applying appropriate measures and procedures necessary for the continuous identification of hazards, risk assessment and implementation of necessary control measures.
GENDER FEATURES OF LEADERSHIP THROUGH THE PRISM OF THE THEORY OF SOCIAL REGULATORS
Authors: Malyavin S. 
Published: February 2023

The article discusses the issues of gender characteristics of the leadership. Based on the analysis of the works of classics of psychological and sociological science, as well as relying on secondary data from empirical studies of modern scientists, the author shows that gender differences take place, however, it has not been established whether they are fully gender, i.e. developed ultimately under the influence of socialization or «children’s complexes,» «archetypes,» stereotypes.» Or it may be the result of a typical expected reaction by others to the behavior of male and female leaders. And their ability to give the right answer to the challenge of the environment is the ability to be a leader. And it doesn’t matter who you are a man or a woman.
Food Donations, Retail Operations, and Retail Pricing
Authors: Lowrey John D. , Richards Timothy J. , Hamilton Stephen F. 
Published: February 2023

Problem definition: For grocery retailers, managing perishable food that is nearing expiry is a major challenge. Donating food to food banks is socially responsible, as it improves local communities and reduces waste generation. It also diverts food to a secondary, quality-differentiated market. Academic/practical relevance: In this paper, we quantify the economic impacts of this secondary market for food by examining donation and pricing behaviors for competing retailers. Methodology: We use a structural model of price-discriminating oligopoly retailers to study the effect of food donations on store and category-level demand and equilibrium prices. Empirically, we estimate the food donation effect using a unique data set of food donations and sales for several categories of perishable foods across two major retail chains that compete in the same market. Results: The competitive effects of food donations follow from the price-discrimination logic. First, food donations create a direct demand effect. Donations raise the average quality of products on display, shifting demand curves inward and rotating them clockwise (e.g., more inelastic). Second, food donations create a market enhancement effect, softening price competition and raising equilibrium prices among competing retailers. Managerial implications: Food donations increase food prices and store profits, tying the socially responsible option to an economic benefit. This study contributes a new type of reuse operation to the literature on closed-loop supply chains.Funding: Funding from the Agriculture and Food Research Initiative (National Institute for Food and Agriculture, U.S. Department of Agriculture) [Grant 2020-67021-31377] is acknowledged.Supplemental Material: The online supplement is available at https://doi.org/10.1287/msom.2022.1185 .
Repositioning Vocational and Technical Education in Nigeria: Work-Based Versus Work-Place Learning and Skill Acquisition Order
Authors: Adebisi Tajudeen , Santosa Budi 
Published: February 2023

Vocational and technical education (VTE) is a stratum of education system that deals directly with acquisition of skills for work. Nigeria’s National Policy on Education (NPE) in Section 7 Numbers 40 to 57 expansively stresses the need for VTE with a view to producing formidable workforce with relevant vocational and technical competences necessary for sustainable national development. On this premise, this paper underscores repositioning VTE in Nigeria. This article conceptually explores the similarities as well as the differences between work-based learning and work-place learning. How these two concepts result into vocational and technical skill acquisition with their attendant demands forms a major section of this paper. The paper views that if the opportunities for job skills acquisition offered by work-based and work-place learning could be purposively harnessed into the nation’s educational programme, the ever-rising unemployment rate in the country would drastically be alleviated.
School Contribution to the Community in the Implementation of Vocational High School Empowering Village Program in Kalibawang Sub-District of Wonosobo
Authors: Riyadi Riyadi , Sayuti Muhammad , Susatya Edhy 
Published: February 2023

The objectives of this study are (1) to analyze the contribution of SMK Negeri 1 Kalibawang in efforts to empower the village community of Kalibawang District through the implementation of the 'SMK Membangun Desa' program; (2) analyze the factors supporting the contribution of SMK in efforts to empower the village community of Kalibawang District in the implementation of the 'SMK Membangun Desa' program; (3) analyze the inhibiting factorsfor smk's contribution in efforts to empower the village community of Kalibawang District in the implementation of the 'SMK Membangun Desa' program.
The research uses a qualitative approach with phenomenological strategies in the implementation of the 'SMK Membangun Desa' program. The research was carried out at SMK Negeri 1 Kalibawang and the Kalibawang District Government. Data collection is carried out by interview, observation, and documentation techniques. Data analysis and validation using source triangulation techniques.
The results showed that (1) the implementation of the 'SMK Membangun Desa' program is able to contribute to the improvement of human resources (HR) of the community and the economy of the Kalibawang community through community empowerment strategy-based activities that are integrated with the needs in the village and become one of the solutions to improve the competence of students in the industrial world and theproductivity of students, including: career center on each competency of expertise (Motorcycle Engineering and Business, Accounting and Financial Institutions, Computer and Network Engineering), banana cultivation on SMK land, entrepreneur e-workshop training, marketing of home industry products, promotion of tourist village destinations, community service, sharing public health, and launching program 'SMK Building Villages towards superior smk based on empowerment. (2) supporting factors in the implementation of the 'SMK Membangun Desa' program are the support of the village government, the ability of competent vocational schools, adequate infrastructure and facilities, and the commitment of all SMK residents. (3) inhibiting factors in the implementation of the 'SMK Membangun Desa' program regarding time constraints that arethe same as the Coronavirus Disease 2019 pandemic, and program fundingcan be andmanaged independently because it is not a program assistance from the government.
Experiences of staff and the support received following incidents of high-risk behaviours in acute mental health inpatient wards: a qualitative exploration
Authors: Rivett Emma , Wood Lisa 
Published: February 2023

Background/AimsStaff working in acute mental health inpatient environments are frequently exposed to patients who display high-risk behaviours. The aim of the study was to explore the experiences of staff working with patients with high-risk behaviours in acute mental health inpatient wards, and the support that staff receive following exposure to these incidents.MethodsA total of 10 participants were recruited from two acute mental health hospitals in England. Data were gathered using semi-structured interviews and analysed using inductive thematic analysis.ResultsThree themes were identified: the direct impact of incidents; attempts to manage the impact of incidents; and current systems for managing incidents.ConclusionsOverall, staff felt that support was lacking, and there was a fear that seeking support was a sign of weakness. Clear differences in staff reactions and responses to varying high-risk behaviours were revealed. Person-centred reflective support spaces, debriefing support, and skills training for staff, especially for self-harm and suicide, are required. Staff also require emotional support and emotion management skills.