bluuebunny/crossref_metadata_2025_split huggingface dataset:
Growth differentiation factor 11 promotes macrophage polarization towards M2 to attenuate myocardial infarction via inhibiting Notch1 signaling pathway
Authors: Gong Manyu , Yang Xuewen , Wang Yaqi , Wang Yanying , Liu Dongping , Li Haodong , Qu Yunmeng , Zhang Xiyang , Zhang Yanwei , Sun Han , Jiao Lei , Zhang Ying 
Published: January 2023

Abstract

Background
Myocardial infarctions (MI) is a major threat to human health especially in people exposed to cold environment. The polarization of macrophages towards different functional phenotypes (M1 macrophages and M2 macrophages) is closely related to MI repairment. The growth differentiation factor 11 (GDF11) has been reported to play a momentous role in inflammatory associated diseases. In this study, we examined the regulatory role of GDF11 in macrophage polarization and elucidated the underlying mechanisms in MI.

Methods

In vivo, the mice model of MI was induced by permanent ligation of the left anterior descending coronary artery (LAD), and mice were randomly divided into the sham group, MI group, and MI+GDF11 group. The protective effect of GDF11 on myocardial infarction and its effect on macrophage polarization were verified by echocardiography, triphenyl tetrazolium chloride staining and immunofluorescence staining of heart tissue. In vitro, based on the RAW264.7 cell line, the effect of GDF11 in promoting macrophage polarization toward the M2 type by inhibiting the Notch1 Signaling pathway was validated by qRT-PCR, Western blot, and flow cytometry.

Results
We found that GDF11 was significantly downregulated in the cardiac tissue of MI mice. And GDF11 supplementation can improve the cardiac function. Moreover, GDF11 could reduce the proportion of M1 macrophages and increase the accumulation of M2 macrophages in the heart tissue of MI mice. Furthermore, the cardioprotective effect of GDF11 on MI mice was weakened after macrophage clearance. At the cellular level, application of GDF11 could inhibit the expression of M1 macrophage (classically activated macrophage) markers iNOS, interleukin (IL)-1β, and IL-6 in a dose-dependent manner. In contrast, GDF11 significantly increased the level of M2 macrophage markers including IL-10, CD206, arginase 1 (Arg1), and vascular endothelial growth factor (VEGF). Interestingly, GDF11 could promote M1 macrophages polarizing to M2 macrophages. At the molecular level, GDF11 significantly down-regulated the Notch1 signaling pathway, the activation of which has been demonstrated to promote M1 polarization in macrophages.

Conclusions
GDF11 promoted macrophage polarization towards M2 to attenuate myocardial infarction via inhibiting Notch1 signaling pathway.
Pengaruh Residu Pemberian Abu Vulkanis Gunung Agung dan Pupuk Kompos terhadap Tanah dan Tanaman Kacang Tanah (Arachis hypogaea L.)
Authors: NARKA I WAYAN , ARTHAGAMA I DEWA MADE , ATMAJA I WAYAN DANA 
Published: January 2023

Residual Effect of Mount Agung Volcanic Ash and Compost on Soil and Peanut Plants (Arachis hypogaea L.). Research on the application of Mount Agung volcanic ash and compost has been carried out with cowpea as an indicator plant, but volcanic ash has not shown any effect. The volcanic ash of Mount Agung is in the form of material that has not been weathered, so to accelerate weathering it is necessary to add organic matter. The purpose of this study was to determine the residual effect of giving volcanic ash and compost on soil and peanut plant. The design used was a factorial randomized block design with 3 replications. The volcanic ash factor consists of 3 levels, namely A0 = no volcanic ash, A1 = 10% volcanic ash and A2 = 30% volcanic ash. The compost factor consists of 3 levels, namely K0 = without compost, K1 = 10 tons of compost ha-1, and K2 = 20 tons of compost ha-1. Parameters of soil properties observed were : total porosity, nitrogen, phosphorus and potassium content and C-organic matter content. Observation of peanut plants included : plant height, number of pods, weight of oven-dried pods, weight of oven-dried seeds and weight of oven-dried peanut stem. The results of research showed that there was no interaction between the treatment of volcanic ash residue and compost residue on the soil and peanut plants, while the single treatment of compost residue had a significant effect on peanut plants. The treatment of volcanic ash residue has not shown a significant effect, both on the soil and on peanut plants.
Eksplorasi Sumber Daya Genetik Jagung Lokal Bali
Authors: PRADNYAWATHI NI LUH MADE , WIJAYA I KETUT ARSA , SUTEDJA I NYOMAN 
Published: January 2023

Genetic diversity of genetic resources is the basic material for producing superior varieties. These genetic resources can be in the form of local varieties, among others. The purpose of this study was to explore the types of local corn in the province of Bali. The method used was a survey method. The primary data collection techniques were observation and interviews and the secondary data in the form of literature study. The types of local corn obtained were then collected. Exploration was carried out at corn planting centres from August 2020 to November 2020. From the exploration results were found 16 local corn types. In Buleleng Regency, four local corn accessions were found, namely: Pangkung Paruk Barak corn, Pangkung Paruk Putih corn, Local Sambirenteng corn and Cicih Kebo corn. In Karangasem Regency, three local corn were found, namely Seraya corn, Purwakerti Putih corn and Ketan Bunutan corn. In Klungkung Regency, one type of local corn was found, Local Nusa Penida corn. In Bangli Regency, six types of local corn were found, namely Kuning Pengootan corn, Local Landih corn, Panes corn/Kuning Daup corn, Injin Daup corn, Bali Malet Gusti corn and Barak Keliki Kintamani corn. In Badung Regency, two types of local corn were found, namely Belok Sidan corn, and Ketan Belok Sidan corn.
Narsisme Direktur, Komposisi Komisaris Independen dan Gender Direktur Pada Kualitas Laporan Keuangan BUMN
Authors: Syukra Rahmiyatus , Fadjarenie Agustin 
Published: January 2023

The quality of financial reports can be seen through the characteristics adopted, several characteristics that can be assessed, namely the narcissism of the director, the composition of the independent commissioners and the gender of the director. The research objective is to obtain empirical evidence of the influence of director narcissism, composition of independent commissioners and director gender on the quality of financial reports. The research was conducted at companies listed on the Indonesia Stock Exchange for the period 2014 – 2019. The research sample consisted of 180 observations. Data is processed using multiple linear regression analysis. The results showed that the director's narcissism and the composition of the independent commissioners had an effect on the quality of financial reports, while there was no effect on the gender of directors and the quality of financial reports.
Keywords: Narcissism Director; The Composition of Independent Commissioners; Gender Directors on the Quality of Financial Reports
Pengungkapan Sustainability Reporting, Intellectual Capital, dan Nilai Perusahaan
Authors: Dewi Putu Purnama , Dewi Kadek Ayu Kreistya 
Published: January 2023

The study aims to determine the effect of sustainability reporting and intellectual capital disclosures on the value of mining companies listed on the Indonesia Stock Exchange in 2016-2020. This research used a purposive sampling technique in taking the sample using several relevant criteria. Obtained 35 observations as a research sample. The analysis technique used is multiple linear regression. The results of the study explain that the variable disclosure of sustainability reporting and intellectual capital has a positive and significant effect on firm value.
Keywords: Disclosure of Sustainability Reporting; Intellectual Capital; Firm Value.
PERAN KEPUASAN KERJA MEMEDIASI MOTIVASI KERJA TERHADAP KINERJA KARYAWAN PT. BANK RAKYAT INDONESIA (PERSERO) TBK
Authors: Artana Putu Yuwanda , SE., M.Si. Ni Wayan Mujiati 
Published: January 2023

Tujuan penelitian ini adalah menganalisis pengaruh motivasi kerja pada kinerja karyawan, pengaruh motivasi kerja pada kepuasan kerja, pengaruh kepuasan kerja pada kinerja karyawan, dan peran kepuasan kerja dalam memediasi pengaruh motivasi kerja pada kinerja karyawan. Penelitian ini dilakukan pada pegawai PT. Bank Rakyat Indonesia (Persero) Tbk Cabang Kuta yang melibatkan 75 responden dengan teknik pengumpulan sampel non probability sampling. Pengumpulan data menggunakan kuesioner berbasis Google form, teknik analisis data menggunakan analisis deskriptif dan analisis jalur. Hasil penelitian ini menemukan bahwa 1) Motivasi Kerja mempunyai pengaruh positif dan signifikan pada Kinerja Karyawan, 2) Motivasi Kerja mempunyai pengaruh positif dan signifikan pada Kepuasan Kerja, 3) Kepuasan Kerja mempunyai pengaruh positif dan signifikan pada Kinerja Karyawan, 4) Kepuasan Kerja mampu secara positif memediasi pengaruh Motivasi Kerja pada Kinerja Karyawan. Hasil penelitian ini memberikan implikasi kepada pihak terkait tentang motivasi kerja yang tinggi maka semakin tinggi pula kepuasan kerjanya, sehingga kinerja karyawan akan meningkat.
Kata kunci: motivasi kerja, kepuasan kerja, kinerja karyawan
PERAN BRAND IMAGE MEMEDIASI PENGARUH HARGA TERHADAP KEPUTUSAN PEMBELIAN DI MASA PANDEMI (Studi Pada Produk Smartphone Xiaomi di Kota Denpasar)
Authors: Katu Geldy Mahantara Kristindo , Suparna Gede 
Published: January 2023

This study aims to explain the effect of price on purchasing decisions mediated by brand image. This research was conducted on consumers of Xiaomi smartphone products in Denpasar City. The number of samples taken as many as 100 respondents, with a non-probability sampling technique of determining the sample using the purposive sampling method. Data collection was done through a questionnaire. The analysis technique used is Partial Least Square (PLS). Based on the results of the analysis, it was found that price and brand image have a positive and significant effect on purchasing decisions. This shows that the more affordable the price and the better the brand image, the higher the consumer's purchase decision. Price partially has a significant effect on purchasing decisions. These results mean that an affordable price can improve the purchasing decision of Xiaomi smartphones. Brand image also partially has a significant effect on purchasing decisions, which can be concluded that the existence of a good brand image can improve purchasing decisions.
Keywords: price, brand image, purchase decision
The Effect of Corporate Governance on Corporate Value: The Role of Enterprise Risk Management
Authors: Sepriani Lena , Candy Candy 
Published: January 2023

In order to determine the effect of corporate governance on the corporate value, then moderating the relationship with enterprise risk management (ERM) is the aim of this study. This study collected secondary data from financial statements and annual reports for the 2016-2020 period of 87 companies as the sample and used panel regression as the analysis method. The results showed a significant positive effect of the audit committee on corporate value, while an independent commissioner had a significant negative effect. This study also shows no significant effect on the corporate value of managerial ownership, institutional ownership, board size, and board director. However, ERM moderated the relationship between the audit committee and corporate value and between managerial ownership and corporate value.
Keyword: Corporate governance, corporate value, ERM.
DIMENSIONS OF PERFORMANCE VALUE OF SHARIA MICRO FINANCE INSTITUTION
Authors: Subagyo Ahmad 
Published: January 2023

ABSTRACTThe performance appraisal of financial institutions is generally measured by using financial ratio indicators. Sharia microfinance institutions are institutions that have been developed by both the Government and the society which have economic and social functions. Social functions that are grown from belief values will have a long-term impacts, both consistency and sustainability. Exploring social values based on Sharia principles is needed to make the operational basis for Islamic microfinance institutions more measurable, both in financial performance and social performance.There are three principles in evaluating the performance of Islamic microfinance institutions, namely (1) the principle of fairness, (2) the principle of honesty, and (3) the principle of partnership. These three principles are the basis for operationalizing LKMS, both in product development, services and corporate governance.Key words: Dimension, Sharia financial principle, Micro finance, fairness, honesty, partnership.
Peran Orang Tua dalam Pembelajaran Daring di Sekolah Dasar
Authors: Pujiastuti Pujiastuti , Ayuhan Ayuhan 
Published: January 2023

This research was motivated by curiosity what is the role of parents when accompanying children to do chores at home during the pandemic. This study aims to determine (1) the role of parents in online learning at SDN Kembangan Utara 09 Pagi Jakarta Barat, (2) Efforts by parents in increasing the seriousness of students in online learning at SDN Kembangan Utara 09 Pagi Jakarta Barat and (3) the obstacles faced faced by parents in online learning at SDN Kembangan Utara 09 Pagi, Jakarta Barat. The methodology of this research is qualitative. The subjects in this study were parents and homeroom teachers for grade II at SDN Kembangan Utara 09 Pagi, Jakarta Barat. Data collection was taken through interviews, observation, documentation. The author acts as a direct interviewer to collect data through parents and second grade homeroom teachers. The results showed that (1) The role of parents in online learning at SDN Kembangan Utara 09 Pagi Jakarta Barat is to have three roles at once, namely the role of parents, breadwinners and teachers at home (2) The efforts of parents in increasing the seriousness of students in online learning at SDN Kembangan Utara 09 Pagi Jakarta Barat is to provide motivation, guidance and assistance (3) Obstacles faced by parents in online learning at SDN Kembangan Utara 09 Pagi Jakarta Barat are limited infrastructure facilities, such as mobile phones, motivation, internet quota and time. Keywords : Parents, Online Learning and Motivation
Pelatihan Pemanfaatan Limbah Bawang Merah Sebagai Pupuk Organik Cair Bagi Masyarakat Desa Puhkerep Kabupaten Nganjuk
Authors: Krismiratsih Fitri , Pristiwaningsih Estin Roso , Saputra Geri Barnas 
Published: January 2023

Desa Puhkerep kecamatan Rejoso Kabupaten Nganjuk mayoritas penduduk desanya adalah petani, komoditas yang paling banyak dibudidayakan adalah bawang merah. Kegiatan budidaya ini menghasilkan limbah pertanian yang paling banyak pada proses pascapanen berupa limbah sisa daun dan kulit kering. Keberadaan limbah ini dapat mencemari lingkungan baik pencemaran bau, pandangan maupun kerusakan lingkungan dan juga sebagai sumber penyakit. Oleh karena itu bisa dilakukan penanganan limbah menjadi pupuk organic cair. Pupuk organik cair melalui proses fermentasi melaui alat sederhana, dengan ditambah bahan lainnya berupa molase, air leri, bantuan mikroorganisme EM-4. Kegiatan pengabdian ini dilakukan pada kelompok ibu-ibu yang berada di Desa Puhkerep Kecamatan Rejoso Kabupaten Nganjuk. Melalui kegiatan ini diharapkan dapat meningkatkan pengetahuan dan kemampuan penaganan limbah bawang merah dan juga bisa membuat pupuk organik cair sendiri.
اليقظة الذهنية وعلاقتها بالتفكير الإبداعي لدى طلبة جامعة الكتاب
Authors: Raziq Faisal Hamdi , Ghadab Wissam kurdi 
Published: January 2023

يهدف البحث الحالي الى التعرف على مستوى اليقظة الذهنية لدى طلبة الجامعة. والتعرف على دلالة الفرق في اليقظة الذهنية تبعاً لمتغيري ( الجنس والتخصص) .والتعرف على مستوى التفكير الابداعي لدى طلبة الجامعة. التعرف على دلالة الفرق تبعاً لمتغيري ( الجنس والتخصص) .التعرف على العلاقة بين اليقظة الذهنية والتفكير الابداعي لدى طلبة الجامعة. اعتمد البحث الحالي على المنهج الوصفي . وشملت عينة البحث ( 200 ) طالب وطالبة من طلبة جامعة الكتاب، واستخدم الباحث الادوات الاتية، اعداد مقياس اليقظة الذهنية ومقياس التفكير الابداعي، واستخدام الاساليب الاحصائية معامل ارتباط بيرسون, الاختبار التائي لعينة واحدة وكانت النتائج وجود يقظة ذهنية لدى طلبة الجامعة، أظهرت نتائج الدراسة وجود فرق ذي دلالة إحصائية بين الجنسين، والتخصص في اليقظة الذهنية لصالح الذكور، التخصص العلمي . وتشير النتائج على عينة البحث يمتلكون تفكيراً ابداعياً. عدم وجود فروق دالة في الجنس ، وجود فرق ذي دلالة إحصائية وفقا للتخصص ولصالح التخصص الادبي.
Uses of Periphrastic Do in English
Authors: Eltaif Suaad Abdul- Rahman 
Published: January 2023

This study aims at clarifying the definitions, structures ,conditions and uses of Periphrastic Do (PD) in English. PD is an auxiliary , it is an alternative device for using inflection process. It is semantically not intrinsic but syntactically obligatory. It is used to satisfy the needs of the sentence structures.
It can be used in verbal negation, negative preposed constituents, inverted questions, anphoric PD and tag questions.
In these structures , only the use of PD is correct and necessary . It is a syntactic device that performs a special function. During the years, PD underwent a change and development from zero to obligatory use in specific contexts.
Perspectives: Paraffin, a Burning Issue for Economically Vulnerable People
Authors: Andrews Ethel 
Published: January 2023

The price of life in South Africa is cheap. The official price of illuminating paraffin was R16.90 (US$1) for March 2022 at the petrol pumps. The purchase price to consumers varies depending on availability, markups and convenience and can cost up to R25 (US$1.51) per litre. It has been reported that each year the direct cost of R490 million (US$29 661 016.90) is spent on caring for patients with paraffin burns. Sadly, this is not the full picture. When considering the price paid for a commodity one must deliberate what is the real cost for the use of the commodity. Henry David Thoreau’s quotation: “The cost of a thing is the amount of life, which is required to be exchanged for it, immediately or in the long run” encapsulates the price-versus-cost argument on the use of illuminating paraffin. Both direct and indirect costs must be considered to obtain the accurate cost of paraffin in the context of treating burns. The estimated total direct cost of treating a single patient with a 20% body surface area with deep dermal thickness burn was estimated between R103 000 (US$6 234.87) and R154 000 (US$9 322.03) per year in 2011. The indirect or hidden cost is the amount not considered or calculated, yet someone is paying for it albeit the patient, their family and friends or society. The cost of treating burns undeniably is far more than the mere price of the product, far more than the direct cost of R154 000 (US$9 322.03); it can literally cost the patient’s life and the family’s livelihood. Paraffin is cheap, life is not. The objective of this article is to accentuate the exorbitant cost associated with treating paraffin burns to create awareness among policymakers and decision makers about a silent consequence of the use of a cheap commodity.
GESTÃO SUSTENTÁVEL DE EVENTOS: ANÁLISE DA SUSTENTABILIDADE DE UM EVENTO ACADÊMICO
Authors: Maciel Ana Luisa Teles , Maciel Joylan Nunes , Dechechi Eduardo Cesar , Damke Elói Junior 
Published: January 2023

Este estudo objetivou analisar a sustentabilidade de um evento acadêmico anual realizado pela Universidade Federal da Integração Latino-Americana – UNILA a partir dos indicadores de sustentabilidade definidos no guia prático para eventos sustentáveis em instituições de educação superior (LEME; MORTEAN; BRANDÃO, 2014), bem como, na (ISO, 2012) considerando as dimensões econômica, social e ambiental. A metodologia é caracterizada como pesquisa exploratória por intermédio de estudo de caso e a abordagem é qualitativa. Os dados foram coletados a partir de documentos, publicações digitais da organização e entrevistas semiestruturadas aos membros da comissão organizadora do evento. Para organização dos dados foi utilizado o software Atlas.ti e o Microsoft Office Excel, categorizados a partir do “Guia prático para eventos sustentáveis em IES”. As inferências foram realizadas por meio do método de análise de conteúdo (BARDIN, 2011). Os resultados permitiram identificar no âmbito da gestão sustentável de eventos, que a Semana Integrada de Ensino Pesquisa e Extensão da Universidade Federal da Integração Latino-Americana - SIEPE obteve classificação Prata em relação ao último evento analisado (2019), o que evidenciou a necessidade de realizar melhorias, para as quais foram realizadas proposições e contribuições a serem implementadas nas futuras edições.
MANAJEMEN PERENCANAAN PESERTA DIDIK PENGHAFAL QURAN DI SMP TAHFIDH AL HIDAYAH KALANGBRET TULUNGAGUNG JAWA TIMUR
Authors: Permatasari Futika , Novitasari Erika , Lestari Nia Agus 
Published: January 2023

ABSTRAKPenelitian ini bertujuan untuk mendeskripsikan manajemen perencanaan peserta didik di SMP Tahfidh Al Hidayah Tulungagung yakni meliputi penerimaan, seleksi, orientasi, penempatan, pelaporan dan pencatatan peserta didik. Penelitian ini merupakan penelitian studi kasus dengan menggunakan pendekatan kualitatif. Subjek penelitian pada penelitian ini adalah Kepala Sekolah, Wakil Kepala Sekolah dan guru SMP Tahfidh Al Hidayah. Pengumpulan data pada penelitian ini dilakukan dengan wawancara mendalam, observasi dan studi dokumentasi. Sedangkan tahap analisis data, peneliti menggunakan model interaktif Miles dan Huberman yakni pengumpulan data, reduksi data, penyajian data dan penarikan kesimpulan. Hasil penelitian ditemukan bahwa pada managemen perencanaan peserta didik terdapat beberapa tahap yang dilakukan yakni 1) Analisis kebutuhan peserta didik; 2) Seleksi penerimaan siswa baru berdasarkan jalur prestasi dan jumlah hafalan Al Quran sebanyak minimal 5 juz; 3) Orientasi siswa; 4) penempatan; 5) Pelaporan dan pencatatan peserta didik. Kata Kunci: Manajemen Perencanaan, Peserta Didik
Pengaruh Gender, Latar Belakang Pendidikan Dan Literasi Keuangan Terhadap Perilaku Pengelolaan Keuangan UMKM Di Masa Pandemi (Studi Pada UMKM Eksportir Kabupaten Lombok Barat Yang Terdaftar Di Dinas Perdagangan Provinsi NTB)
Authors: Supalawati Maiwa , Hidayati Siti Aisyah , Suryani Embun , Wahyulina Sri 
Published: January 2023

The purpose of this study was to examine the effect of gender, educational background and financial literacy on MSMEs financial management behavior during the pandemic. This research is an associative quantitative study with a sample of 30 MSMEs exporters in the West Lombok district registered at the NTB provincial trade office. The sampling technique used is purposive sampling with the predetermined criteria. The data analysis is carried out using the SPSS Statistic 24 program. This study obtained the results that gender had no effect on financial management behaviour, educational background had an effect on financial management behaviour, and financial literacy had no effect on the financial management behavior of MSMEs during the pandemic.