bluuebunny/crossref_metadata_2025_split huggingface dataset:
New stable ultrawide bandgap As2O3 semiconductor materials
Authors: Abdullahi Yusuf Zuntu , Caglayan Rabia , Mogulkoc Aybey , Mogulkoc Yesim , Ersan Fatih 
Published: March 2023

Abstract
Ultrawide band gap materials have numerous potential applications in deep ultraviolet optoelectronics, as well as next-generation high-power and radio frequency electronics. Through the first-principles calculations based on density functional theory calculations, we demonstrate that the As2O3 bulk and monolayer structures have excellent energetic, mechanical, and thermal stabilities. The bulk and monolayer of As2O3 come in two distinct structures, namely st1-As2O3, and st2-As2O3. We show that the st1-As2O3 and st2-As2O3 monolayer and bilayer could be mechanically exfoliated from their bulk material and found that the cleavage energy values are significantly lower than those reported for similarly layered materials. By performing Perdew–Burke–Ernzerhof (PBE) and Heyd–Scuseria–Ernzerhof (HSE06) band structure calculations, we found that the bulk and monolayers of As2O3 structures exhibit wide (PBE) and ultra-wide (HSE06) indirect band gaps. We further evaluate the As2O3 layered thickness-dependent band gaps and found that band gap decreases uniformly as the number of st1-As2O3 and st2-As2O3 layers increases. Our findings demonstrate the potential of the As2O3 structures for the future design of ultra-wide band gap semiconductor electronic devices.
Electric discharge coating process: a critical review with potential application
Authors: Kumaran V , Muralidharan B 
Published: March 2023

Abstract
Electric discharge coating (EDC) process is a competitive surface coating technology that alters the desired surface characteristics. EDC process deposits the material on the substrates from the sacrificial electrode by spark erosion process with the potential advantage of depositing any materials. This paper extensively reviews the work carried out in the EDC process and suggests areas of improvement for easy adaptability in industrial applications. Here, the variants of the EDC process, the route map for process parameter selection, the advantage over conventional methods, and coating characterization are discussed. The review sequentially presents the fundamental process, detailed analysis of tool and workpiece materials used, process parameters, and applications. EDC process has continued to be a key solution for many industrial needs, with the critical advantage of enhancing the substrate’s serviceability and protecting against corrosion, thermal stress, and other adverse environmental conditions. The scope of the work is discussed in detail, with potential industrial and biomedical applications suggesting avenues for researchers and industrialists.
Ultra-low latency recurrent neural network inference on FPGAs for physics applications with hls4ml
Authors: Khoda Elham E , Rankin Dylan , Teixeira de Lima Rafael , Harris Philip , Hauck Scott , Hsu Shih-Chieh , Kagan Michael , Loncar Vladimir , Paikara Chaitanya , Rao Richa , Summers Sioni , Vernieri Caterina , Wang Aaron 
Published: March 2023

Abstract
Recurrent neural networks have been shown to be effective architectures for many tasks in high energy physics, and thus have been widely adopted. Their use in low-latency environments has, however, been limited as a result of the difficulties of implementing recurrent architectures on field-programmable gate arrays (FPGAs). In this paper we present an implementation of two types of recurrent neural network layers—long short-term memory and gated recurrent unit—within the hls4ml framework. We demonstrate that our implementation is capable of producing effective designs for both small and large models, and can be customized to meet specific design requirements for inference latencies and FPGA resources. We show the performance and synthesized designs for multiple neural networks, many of which are trained specifically for jet identification tasks at the CERN Large Hadron Collider.
Projected expansion of hottest climate zones over Africa during the mid and late 21st century
Authors: Dajuma Alima , Sylla Mouhamadou Bamba , Tall Moustapha , Almazroui Mansour , Yassa Nourredine , Diedhiou Arona , Giorgi Filippo 
Published: March 2023

Abstract
Projected shifts in thermal climate zones over Africa during the mid and late 21st century are assessed by employing the Thornthwaite thermal classification applied to 40 CMIP6 global climate models under the SSP1-2.6, SSP2-4.5 and SSP5-8.5 forcing scenarios. The CMIP6 multimodel ensemble mean reproduces the observed pattern of thermal zones during the reference period, albeit with some discrepancies. The projections reveal a gradual expansion of the hottest thermal type consisting of a northward and southward displacement of torrid climate zones, with this effect intensifying as greenhouse gas (GHG) forcing increases and the time horizon moves from the mid to the end of the century. In particular, the Mediterranean region, almost all southern African countries, part of East Africa and most Madagascar predominantly warm in present-day conditions, are projected to face mostly hot climates in the mid—21st century and torrid by the end of the 21st century in the high-end forcing scenario. Generally, in the mid—21st century, torrid climates expand by up to ∼15%, 20% and 27% of total Africa’s land areas for the SSP1-2.6, SSP2-4.5 and SSP5-8.5, respectively, with these fractions increasing to ∼16%, 28% and 42% in the late 21st century. Therefore, at the end of the 21st century for the high-end GHG concentration scenario, the African continent will be covered by 81%–87% of torrid climate type, which will have enormous impacts on the sustainable development of African countries.
Mobile emergency department care to nursing home residents: a novel outreach service
Authors: Udesen Stine Emilie Junker , Rasmussen Claus-Henrik , Mikkelsen Søren , Andersen Nina , Brabrand Mikkel , Lassen Annmarie Touborg 
Published: March 2023

Abstract

Background
Every month, 6% of Danish nursing home residents are admitted to hospital. However, these admissions might have limited benefits and are associated with an increased risk of complications. We initiated a new mobile service comprising consultants performing emergency care in nursing homes.

Objective
Describe the new service, the recipients of this service, hospital admission patterns and 90-day mortality.

Design
A descriptive observational study.

Model
When an ambulance is requested to a nursing home, the emergency medical dispatch centre simultaneously dispatches a consultant from the emergency department who will provide an emergency evaluation and decisions regarding treatment at the scene in collaboration with municipal acute care nurses.

Method
We describe the characteristics of all nursing home contacts from 1st November 2020 to 31st December 2021. The outcome measures were hospital admissions and 90-day mortality. Data were extracted from the patients’ electronic hospital records and prospectively registered data.

Results
We identified 638 contacts (495 individuals). The new service had a median of two (interquartile range: 2–3) new contacts per day. The most frequent diagnoses were related to infections, unspecific symptoms, falls, trauma and neurologic disease. Seven out of eight residents remained at home following treatment, 20% had an unplanned hospital admission within 30 days and 90-day mortality was 36.4%.

Conclusion
Transitioning emergency care from hospitals to nursing homes could present an opportunity for providing optimised care to a vulnerable population and limiting unnecessary transfers and admissions to hospitals.
Assessing the impact of a payor-funded embedded clinical pharmacist on patient and provider satisfaction in a private primary care practice
Authors: Gadd Shannon , Cox Nicholas , Slager Stacey , Pinnock Emily , Mitchell Matthew , Turner Kyle 
Published: March 2023

Abstract

Purpose
With expanding roles of clinic-embedded pharmacists comes the need to identify routes for optimization, soliciting and addressing feedback, and justifying the position(s) to the employing institution. Studies have demonstrated the benefit of integrating pharmacists into healthcare teams, but these opportunities remain largely limited to major health systems due to a lack of billing avenues for and familiarity with the services pharmacists can provide.

Methods
With funding from and partnership with a third-party payor, a pharmacist was incorporated into a private physician-owned clinic to be a resource to the providers and provide comprehensive medication management to patients. Patient and provider experiences were assessed by survey and interview, respectively, utilizing both Likert-scale and free-response questions. The responses were coded, analyzed, and aggregated into themes. The demographic and Likert-scale responses were analyzed using descriptive statistics.

Results
Patients reported a high level of satisfaction with the pharmacist’s service, indicating that they felt more comfortable managing their medications and that they would recommend the pharmacist to a family member or friend. Provider satisfaction was also high, with providers stating that they found the recommendations by the pharmacist helpful, that the recommendations improved cardiovascular risk factors in their patients with diabetes, and that, overall, they were satisfied with the care provided by the pharmacist. The primary concern from the providers was a lack of understanding regarding how best to reach and utilize the service.

Conclusion
Overall, an embedded clinical pharmacist providing comprehensive medication management at a private primary care clinic had a positive impact on both provider and patient satisfaction.
Analytical Approximations and Monge–Ampère Masses of Plurisubharmonic Singularities
Authors: Li Chi 
Published: March 2023

AbstractWe construct examples of plurisubharmonic functions with isolated singularities at $0\in {{\mathbb {C}}}^n$, whose residual Monge–Ampère masses at the origin cannot be approximated by masses of canonical analytic approximations obtained via multiplier ideals. This answers negatively a conjecture of Demailly, and shows that residual Monge–Ampère masses are not valuative invariants of plurisubharmonic singularities.
A Cage Went in Search of a Bird
Authors: Bouwknegt Thijs B , Nauta Bart 
Published: March 2023

Abstract
What happens to people who are accused of atrocity crimes at the bar of public opinion, are publicly indicted, prosecuted, tried, acquitted of criminal charges and then released? Does the mud stick? Or can the dirt also turn into gold, after legal exoneration and possible compensation? This article seeks to trigger a conversation on the international justice community’s stance on condemnation, compensation and convalescence. Through several versatile histories and stories, it gauges how exonerated persons have been navigating life after acquittal. To what extent have they managed to reverse, or recover from, their previous scandalizations, and if so: how? In thinking about this question, we problematize international justice community protagonists and prosecution services’ modus operandi (and effects) of scandalizing first and prosecuting alleged atrocitaires later. We observe that under the International Criminal Court (ICC)’s current circumstances (operating like a cage in search of birds) more suspects have been scandalized than convicted, but that often the scandal lingers. We conclude that for most acquitted persons requesting post-trial compensation is a dead end, and that doing so for some might further increase reputational damage. While several acquitted people ultimately remained defamed, some exonerated persons fully recovered from the human rights scandal by redefining compensation, and by turning the table and scandalizing the ICC.
Indolocarbazole alkaloid Loonamycin A inhibits triple-negative breast cancer cell stemness and Notch signalling
Authors: Xue Wenwen , Li Wuhao , Yu Ying , Zhang Bo , Wang Yixue , Zhou Lin , Chen Zhixiu , Wang Liwei , Ge Huiming , Xu Qiang , Shen Yan 
Published: March 2023

Abstract

Objectives
Enrichment for therapy-resistant cancer stem cells hampers the treatment of triple-negative breast cancer. Targeting these cells via suppression of Notch signalling can be a potential therapeutic strategy. This study aimed to uncover the mode of action of a new indolocarbazole alkaloid loonamycin A against this incurable disease.

Methods
The anticancer effects were examined in triple-negative breast cancer cells using in vitro methods, including cell viability and proliferation assays, wound-healing assay, flow cytometry and mammosphere formation assay. RNA-seq technology was used to analyse the gene expression profiles in loonamycin A-treated cells. Real-time RT-PCR and western blot were to evaluate the inhibition of Notch signalling.

Key findings
Loonamycin A has stronger cytotoxicity than its structural analog rebeccamycin. Besides inhibiting cell proliferation and migration, loonamycin A reduced CD44high/CD24low/− sub-population, mammosphere formation, as well as the expression of stemness-associated genes. Co-administration of loonamycin A enhanced antitumour effects of paclitaxel by inducing apoptosis. RNA sequencing results showed that loonamycin A treatment caused the inhibition of Notch signalling, accompanied by the decreased expression of Notch1 and its targeted genes.

Conclusions
These results reveal a novel bioactivity of indolocarbazole-type alkaloids and provide a promising Notch-inhibiting small molecular candidate for triple-negative breast cancer therapy.
A study of GeV gamma-ray emission towards supernova remnant G51.26+0.11 and its molecular environment
Authors: Zhong Wen-Juan , Zhang Xiao , Chen Yang , Zhang Qian-Qian 
Published: March 2023

ABSTRACT
We reanalyse the Fermi-LAT (Large Area Telescope) GeV γ-ray emission in the region of supernova remnant (SNR) G51.26+0.11 and investigate its interstellar molecular environment with the CO line data. At GeV energies, based on 13.2 yr of Fermi-LAT data, the extended γ-ray emission observed in this region is resolved into a uniform-disc source (‘Src A’) with a significance of 19.5σ and a point source (4FGL J1924.3+1628) with a significance of 4.2σ in 0.2–500 GeV. With an angular radius of ∼0.17○, ‘Src A’ overlaps with SNR G51.26+0.11 significantly in the line of sight. On the other hand, the morphological coincidence between the SNR and the ∼+54 km s−1 molecular clouds (MCs) together with the asymmetric or broad 12CO line profiles near the SNR boundary provides evidence for the very likely SNR–MC interaction. The SNR–MC interaction and the H i absorption features indicate that SNR G51.26+0.11 is located at a kinematic distance of 6.2 ± 0.5 kpc. Combined with the results from the multiwavelength analysis, the γ-ray emission of the SNR (‘Src A’) can be naturally explained by a hadronic model with a soft power-law proton spectrum of index ∼2.25.
An unusual cause for a colonic stricture: a case of Mycobacterium xenopi mimicking malignancy
Authors: Rees J R E , Longstaff A , Rigby H L , Smith D L , Dixon A R 
Published: March 2023

Abstract
Colonic strictures are very common and are a frequent finding on double contrast barium examination; they very often reflect the presence of malignancy, diverticular disease, ischaemia, inflammatory bowel disease, and rarely mycobacterial disease. A case of mycobacterial disease mimicking malignancy is presented; this was due to a rare mycobacterial subtype and there was complete resolution of symptoms with antimycobacterial therapy.
On Our Own: Social Distance, Physical Loneliness, and Structural Isolation in the COVID-19 Pandemic
Authors: Klinenberg Eric , Leigh Jenny K 
Published: March 2023

ABSTRACT
The early months of the COVID-19 pandemic were defined by distance and isolation, raising concerns about widespread loneliness. Drawing on 55 in-depth interviews with residents of New York City who lived alone during the first wave of the pandemic, this article examines the experience of living alone and dealing with loneliness during the early months of the COVID-19 pandemic, asking: What are the specific aspects of being or feeling alone that cause distress? Four key themes emerged from the interviews. First, although most interviewees reported experiencing loneliness at some point during the pandemic, they described themselves as being quite socially connected to friends and family. Second, being physically alone was especially distressing. Third, city residents who lived alone struggled with the loss of everyday interactions with neighbors and familiar strangers who had previously provided regular companionship in public gathering places. Fourth, solo dwellers reported that despite the social and emotional challenges of living alone, feeling abandoned or marginalized by society at large – a phenomenon that we refer to as “structural isolation” – was ultimately a greater emotional burden. These findings highlight the importance of social and structural dimensions of loneliness, helping to sharpen our existing sociological conceptualization of loneliness.
Barriers and Facilitators to Knowledge Brokering Activities: Perspectives from Knowledge Brokers Working in Canadian Rehabilitation Settings
Authors: Gaid Dina , Ahmed Sara , Thomas Aliki , Bussières André 
Published: March 2023

Introduction:Knowledge translation experts advocate for employing knowledge brokers (KBs) to promote the uptake of research evidence in health care settings. Yet, no previous research has identified potential barriers for KBs to promote the uptake of research evidence in rehabilitation settings. This study aimed to identify the barriers and facilitators for KBs in Canadian rehabilitation settings as perceived by individuals serving as KBs.Methods:Qualitative study using semistructured telephone interviews with individuals performing KB activities in rehabilitation settings across Canada. The interview topic guide was informed by the Consolidated Framework for Implementation Research (CFIR) and consisted of 20 questions covering three domains (characteristics of individuals, inner setting, and outer settings). We conducted qualitative descriptive analysis combining deductive coding guided by the CFIR.Results:Characteristics of individuals included having communication skills, clinical experience, research skills, and interpersonal features, in addition to being confident and motivated and receiving training. The inner setting domain included having constant networking with stakeholders and being aware of stakeholders' needs, in addition to resources availability, leadership engagement, knowledge accessibility, prioritizing brokering activities, and monitoring KBs' performance. Finally, the outer setting domain showed that KBs need to be connected to a community of practice to promote information exchange and avoid work duplications.Discussion:Factors likely to hinder or promote the optimal use of KBs within Canadian rehabilitation settings include skill sets and networking abilities; organizational culture, resources, and leadership engagement; and the need for specific training for KBs and for evaluation tools to monitor their performance.
Treatment of postsurgical trigeminal neuralgia with Fu’s subcutaneous needling therapy resulted in prompt complete relief: Two case reports
Authors: Gao Youling , Sun Jian , Fu Zhonghua , Chiu Po-En , Chou Li-Wei 
Published: March 2023

Rationale:
Trigeminal neuralgia is a recurrent unilateral transient electroshock-like pain. Fu’s subcutaneous needling (FSN), used to treat the musculoskeletal problems, has not been reported in this field.

Patient concerns:
The pain extent of case 1 had no reduction after the previous microvascular decompression, the pain of case 2 relapsed 4 years after the microvascular decompression.

Diagnoses:
Postsurgical trigeminal neuralgia.

Interventions:
FSN therapy was applied on the muscles around the neck and face area, which the myofascial trigger points were palpated in these muscles. The FSN needle was inserted into the subcutaneous layer and the needle tip was pointed toward the myofascial trigger point.

Outcomes:
The following outcome measurements were observed before and after treatment, including numerical rating scale, Barrow Neurology Institute Pain Scale scores, Constant Face Pain Questionnaire scores, Brief Pain Inventory-Facial scores, Patient Global Impression of Change scores, and medication dosage. The follow-up surveys were made after 2 and 4 months respectively. The pain of Case 1 was significantly reduced after 7 times FSN treatments and the pain of Case 2 was even disappeared after 6 times FSN treatments.

Lessons:
This case report suggested that FSN can relieve postsurgical trigeminal neuralgia safely and effectively. Clinical randomized controlled studies are needed to be further conducted.
Malignant melanoma in the stomach treated with endoscopic submucosal dissection: a case report
Authors: Suto Daisuke , Yoshida Masashi , Otake Takaaki , Osawa Yosuke , Yamada Hidehiko , Sato Kiichi , Akita Takayuki , Ohdaira Hironori , Suzuki Yutaka , Kohgo Yutaka 
Published: March 2023

Introduction and Importance:
The initial appearance of malignant melanoma localized in the stomach has never been reported previously. We encountered a patient with gastric melanoma in the stomach, which was histologically confirmed to be confined to the mucosa.

Case Presentation:
The patient, when in her 40s, had undergone surgery for malignant melanoma of the left heel. However, there were no detailed records of pathological findings. The patient had a 4-mm black elevated lesion in her stomach observed on esophagogastroduodenoscopy after the eradication of Helicobacter pylori. A year later, esophagogastroduodenoscopy showed that the lesion had increased to 8 mm. A biopsy was performed, but no malignancy was found; the patient continued to be followed up. Esophagogastroduodenoscopy performed at the 2-year follow-up revealed that the melanotic lesion had increased to 15 mm, and biopsy was performed and revealed a malignant melanoma.

Clinical Discussion:
Endoscopic submucosal dissection was performed for gastric malignant melanoma. The margin of the resected malignant melanoma was negative; vascular and lymphatic invasions were not observed, and the lesion was confined to the mucosa.

Conclusion:
We suggest that even if the first biopsy of a melanotic lesion shows no evidence of malignancy, the lesion should be closely monitored. This is the first reported case of endoscopic submucosal dissection of localized gastric malignant melanoma confined to the mucosa.