bluuebunny/crossref_metadata_2025_split huggingface dataset:
Simultaneous Salvage Auto-augmentation: Contemporary Strategy for Management of the Breast Explantation Patient
Authors: Kirwan Laurence , Wazir Umar , Mokbel Kefah 
Published: March 2023

Background:
The treatment of patients requiring explantation of breast prostheses is a complicated clinical issue, for which a consensus regarding the best way forward is still evolving. We believe that simultaneous salvage auto-augmentation (SSAA) is a viable option for the treatment of patients with explantation.

Methods:
Sixteen cases (32 breasts) were reviewed over a 19-year period. The management of the capsule is based on intraoperative findings and not on preoperative evaluation because of the poor interobserver correlation of Baker grades.

Results:
The mean age and clinical follow-up duration were 48 years (range: 41–65) and 9 months, respectively. We observed no complications, and only one patient underwent unilateral surgical revision of the periareolar scar, under local anaesthesia.

Conclusions:
This study suggests that SSAA with or without autologous fat injection is a safe option for women undergoing explantation, with potential aesthetic and cost-saving benefits. In the current climate of public anxiety regarding breast implant illness, breast implant-associated atypical large cell lymphoma, and asymptomatic textured implants, it is anticipated that the number of patients desiring explantation and SSAA will continue to increase.
Standing on the shoulders of bias: lack of transparency and reporting of critical rigor characteristics in pain research
Authors: Plumb Ashley N. , Lesnak Joseph B. , Berardi Giovanni , Hayashi Kazuhiro , Janowski Adam J. , Smith Angela F. , Bailey Dana , Kerkman Cassie , Kienenberger Zoe , Martin Ben , Patterson Ethan , Van Roekel Hannah , Vance Carol G.T. , Sluka Kathleen A. 
Published: March 2023

Abstract
Rigorous experimental design with transparent reporting in biomedical science reduces risk of bias and allows for scientists to judge the quality of the research. Basic factors of rigor such as blinding, randomization, power analysis, and inclusion of both sexes impact the reproducibility by reducing experimental bias. We designed a systematic study to analyze basic factors of rigor, inclusion of sex, and whether data were analyzed or disaggregated by sex over the past 10 years in the journal PAIN. Studies that included humans reported randomization in 81%, blinding in 48%, and the use of a power analysis calculation in 27% over the past 10 years. Studies that included mice reported randomization in 35%, blinding in 70%, and the use of a power analysis in 9%. Studies that included rats reported randomization in 38%, blinding in 63%, and the use of power analysis in 12%. This study also found that human studies consistently included both sexes over the past decade, but less than 20% of data were disaggregated or analyzed for sex differences. Although mouse and rat studies predominately used males only, there has been a slight increase in inclusion of both sexes over the past few years. Justification for single-sex studies was below 50% in both human and rodent data. In both human and animal studies, transparency in reporting of experimental design and inclusion of both sexes should be considered standard practice and will result in improved quality and reproducibility of published research.
Victim-Centered Care Among College Women of Color
Authors: Gepshtein Yana , Burton Candace W. 
Published: March 2023

ABSTRACT

Aims
Women of color are disproportionally affected by intimate partner violence (IPV) and sexual assault (SA), and those on college campuses may have additional risk factors. The purpose of this study was to explore how college-affiliated women of color assign meaning to their interaction with individuals, authorities, and organizations tasked to help survivors of SA and IPV.

Methods
Semistructured focus group interviews (N = 87) were transcribed and analyzed using Charmaz's constructivist grounded theory methodology.

Results
Three priority theoretical elements were identified: what hurts, namely, distrust, uncertain outcomes, and silencing of experiences; what helps, namely, support, autonomy, and safety; and desired outcomes, namely, academic progress, supportive social networks, and self-care.

Conclusion
Participants were concerned about uncertain outcomes of their interaction with organizations and authorities that are set to help victims. Results can inform forensic nurses and other professionals about the care priorities and needs of college-affiliated women of color in the context of IPV and SA.
Population Health
Authors: Harrington Susan A. 
Published: March 2023

Background:
Nursing education is engaged in efforts to respond and adapt to the dynamic fluctuations of health care in the United States. Population health has been revived in this venue of health care involvement in the community and social determinants of health.

Purpose:
The purpose of the study was to define population health and identify topics to include in the undergraduate curriculum, teaching strategies, and skills and competencies needed by new nurses for implementation of population health to improve health outcomes.

Methods:
The study had a mixed-methods design with a survey and an interview distributed to public/community health faculty across the United States.

Results:
Extensive population health topics were suggested for the curriculum, but a significant lack of a structured framework and consistent concepts was noted.

Conclusions:
Topics identified in the survey and through the interviews are illustrated in the tables. These will assist in integrating and scaffolding population health throughout a nursing curriculum.
Baker-IV capsular contracture is correlated with an increased amount of silicone material: an intra-patient study.
Authors: de Bakker Erik , Zada Liron , Schmidt Robert W. , van Haasterecht Ludo , Vethaak A. Dick , Ariese Freek , Dijkman Henry B.P.M. , Bult Peter , Gibbs Susan , Niessen Frank B. 
Published: March 2023

Background:
Breast implant surgery is one of the most frequently performed procedures by plastic surgeons worldwide. However, the relationship between silicone leakage and the most common complication, capsular contracture, is far from understood. This study aimed to compare Baker-I with Baker-IV capsules regarding their silicone content in an intra-donor setting, using two previously validated imaging techniques.

Methods:
Twenty-two donor-matched capsules from eleven patients experiencing unilateral complaints were included after bilateral explantation surgery. All capsules were examined using both Stimulated Raman Scattering (SRS) imaging and staining with Modified Oil Red O (MORO). Evaluation was done visually for qualitative and semi-quantitative assessment and automated for quantitative analysis.

Results:
Using both SRS and MORO techniques, silicone was found in more Baker-IV capsules (8/11 and 11/11, respectively) than in Baker-I capsules (3/11 and 5/11, respectively). Baker-IV capsules also showed significantly more silicone content compared to the Baker-I capsules. This was true for semi-quantitative assessment for both SRS and MORO techniques (p=0.019 and p=0.006, respectively), while quantitative analysis proved to be significant for MORO alone (p=0.026 vs. p=0.248 for SRS).

Conclusions:
In this study, a significant correlation between capsule silicone content and capsular contracture is shown. An extensive and continued foreign body response to silicone particles is likely to be responsible. Considering the widespread use of silicone breast implants these results affect many women worldwide and warrant a more focused research effort.
Difference in the occurrence of capsular contracture according to the characteristics of the tissue in an irradiated rat model
Authors: Kim Hyung Bae , Han Hyun Ho , Eom Jin Sup 
Published: March 2023

Background:
In this study, it was hypothesized that the capsule formation varies according to the radiation dose in the muscle tissues; chest wall tissues, including the ribs; and acellular dermal matrices (ADM) that are in contact with the silicone implant.

Methods:
This study consisted of 20 SD rats that underwent submuscular plane implant reconstruction using ADM. They were divided into four groups: Group 1 as the un-radiated control (n = 5), Group 2 with non-fractionated radiation at a dose of 10 Gy (n = 5), Group 3 with non-fractionated radiation at a dose of 20 Gy (n = 5), and Group 4 with fractionated radiation at a dose of 35 Gy (n = 5). Three months after surgery, hardness was measured. Moreover, the histology and immunochemistry of the capsule tissues of the ADM, muscle tissues, and chest wall tissues were analyzed.

Results:
As the radiation dose increased, the silicone implant became harder. But no significant difference in capsule thickness according to the radiation dose was observed. Based on the tissue in contact with the silicone implant, ADM has a thinner capsule thickness than the muscle tissues and less inflammation as well as less neovascularization compared with the other tissues.

Conclusions:
This study described a new rat model of clinically relevant implant-based breast reconstruction using a submuscular plane and ADM with irradiation. Therefore, it was confirmed that the ADM in contact with the silicone implant, even after irradiation, was protected from radiation compared with the other tissues.
Musculoskeletal Computed Tomography: How to Add Value When Reporting Adult Upper Limb Trauma
Authors: Sivagurunathan Gayathri , Shirodkar Kapil , Hegde Ganesh , Shamshuddin Sameer , Proctor Robin , Naqvi Jawad , Knowles David , Ali Imran 
Published: March 2023

Abstract
There is increasing reliance on computed tomography to evaluate fractures and dislocations following routine evaluation with plain radiography, critical in preoperative planning; computed tomography can provide multiplanar reformats and 3-dimensional volume-rendered imaging, providing a better global assessment for the orthopedic surgeon. The radiologist plays a critical role in appropriately reformatting the raw axial images to illustrate best the findings that will help determine further management. In addition, the radiologist must succinctly report the pertinent findings that will have the most significant bearing on treatment, assisting the surgeon in deciding between nonoperative and operative management. The radiologist should also carefully review imaging to look for ancillary findings in the setting of trauma beyond the bones and joints, including the lungs and rib cage when visualized.
In this review article, we will systematically describe key features for fractures of the scapula, proximal humerus, distal humerus, radial head and neck, olecranon, coronoid process through a case-based approach, and distal radius. Although there are numerous detailed classification systems for each of these fractures, we aim to focus on the core descriptors that underpin these classification systems. The goal is to provide the radiologist with a checklist of critical structures they must assess and findings that they should mention in their report, emphasizing those descriptors that influence patient management.
Importance of Age and Noncontrast-Enhancing Tumor as Biomarkers for Isocitrate Dehydrogenase–Mutant Glioblastoma: A Multicenter Study
Authors: Uetani Hiroyuki , Azuma Minako , Khant Zaw Aung , Watanabe Yoshiyuki , Kudo Kohsuke , Kadota Yoshihito , Yokogami Kiyotaka , Takeshima Hideo , Kuroda Jun-Ichiro , Shinojima Naoki , Hamasaki Tadashi , Mukasa Akitake , Hirai Toshinori 
Published: March 2023

Purpose
This study aimed to investigate the most useful clinical and magnetic resonance imaging (MRI) parameters for differentiating isocitrate dehydrogenase (IDH)-mutant and -wildtype glioblastomas in the 2016 World Health Organization Classification of Tumors of the Central Nervous System.

Methods
This multicenter study included 327 patients with IDH-mutant or IDH-wildtype glioblastoma in the 2016 World Health Organization classification who preoperatively underwent MRI. Isocitrate dehydrogenase mutation status was determined by immunohistochemistry, high-resolution melting analysis, and/or IDH1/2 sequencing. Three radiologists independently reviewed the tumor location, tumor contrast enhancement, noncontrast-enhancing tumor (nCET), and peritumoral edema. Two radiologists independently measured the maximum tumor size and mean and minimum apparent diffusion coefficients of the tumor. Univariate and multivariate logistic regression analyses with an odds ratio (OR) were performed.

Results
The tumors were IDH-wildtype glioblastoma in 306 cases and IDH-mutant glioblastoma in 21. Interobserver agreement for both qualitative and quantitative evaluations was moderate to excellent. The univariate analyses revealed a significant difference in age, seizure, tumor contrast enhancement, and nCET (P < 0.05). The multivariate analysis revealed significant difference in age for all 3 readers (reader 1, odds ratio [OR] = 0.960, P = 0.012; reader 2, OR = 0.966, P = 0.048; reader 3, OR = 0.964, P = 0.026) and nCET for 2 readers (reader 1, OR = 3.082, P = 0.080; reader 2, OR = 4.500, P = 0.003; reader 3, OR = 3.078, P = 0.022).

Conclusions
Age and nCET are the most useful parameters among the clinical and MRI parameters for differentiating IDH-mutant and IDH-wildtype glioblastomas.
Comparison of the Level of Staphylococcus Aureus and Escherichia Coli in Complete Cleft Infants With Normal Infants
Authors: Qays Rula Abdulkareem , Jafar Zainab Juma 
Published: March 2023

Background:
There are many types of oral bacteria, and they differ between healthy children and children with an oral cleft. The purpose of this study was to compare the level of Staphylococcus aureus and Escherichia coli in complete cleft infants with normal infants.

Materials and Methods:
Fifty-two Iraqi infants had participated in this study (26 infants were with cleft and 26 infants were the control healthy group), the study group included 13 infants with class III Veau’s palatal classification, and 13 with class IV Veau’s palatal classification). All are aged from 1 day to 4 months. They were selected and submitted to a questionnaire and clinical examination and bacterial examination. Data description, analysis and presentation were performed using statistical package for social science (SPSS version 21).

Results:
The counting and colonization of S. aureus and GV- (E. coli) were higher in cleft group than in control group.
SILENCING M6A READER YTHDC1 REDUCES INFLAMMATORY RESPONSE IN SEPSIS-INDUCED CARDIOMYOPATHY BY INHIBITING SERPINA3N EXPRESSION
Authors: Xie Wenjing , Zhang Anqi , Huang Xuliang , Zhou Hui , Ying Hangbo , Ye Changzhou , Ren Miao , Qian Meizi , Liu Xia , Mo Yunchang 
Published: March 2023

ABSTRACT
Sepsis-induced cardiomyopathy (SIC) is one of the most common complications of infection-induced sepsis. An imbalance in inflammatory mediators is the main factor leading to SIC. N6-methyladenosine (m6A) is closely related to the occurrence and development of sepsis. N6-methyladenosine reader YTH domain containing 1 (YTHDC1) is an m6A N6-methyladenosine recognition protein. However, the role of YTHDC1 in SIC remains unclear. Herein, we demonstrated that YTHDC1-shRNA inhibits inflammation, reduces inflammatory mediators, and improves cardiac function in a LPS-induced SIC mouse model. Based on the Gene Expression Omnibus database analysis, serine protease inhibitor A3N is a differential gene of SIC. Furthermore, RNA immunoprecipitation indicated that serine protease inhibitor A3N (SERPINA3N) mRNA can bind to YTHDC1, which regulates the expression of SERPINA3N. Serine protease inhibitor A3N–siRNA reduced LPS-induced inflammation of cardiac myocytes. In conclusion, the m6A reader YTHDC1 regulates SERPINA3N mRNA expression to mediate the levels of inflammation in SIC. Such findings add to the relationship between m6A reader YTHDC1 and SIC, providing a new research avenue for the therapeutic mechanism of SIC.
Crisis Scenarios for Simulation-Based Nontechnical Skills Training for Cardiac Surgery Teams
Authors: Kemper Tom , van Haperen Maartje , Eberl Susanne , Winkelman Toon , van Deventer San-Mari , Waller Elbert , Preckel Benedikt 
Published: March 2023

Background
Nontechnical skills in cardiac surgery are vital in ensuring patient safety in the operating room (OR). To train these skills in a simulation-based scenario, a collection of commonly accepted crisis scenarios is needed to serve as a framework for a simulation-based training program.

Objective
The objective of this study was to identify and reach consensus on a collection of relevant crisis scenarios in cardiac surgery suitable for simulation-based team training focusing on nontechnical skills.

Methods
Using the Delphi method, a national assessment was performed among cardiac surgeons, cardiac anesthesiologists, clinical perfusionists, and cardiac OR nurses in the Netherlands. In the first Delphi round, potential crisis scenarios for simulation-based team training in cardiac surgery were identified. In the second round, the identified scenarios were rated using a 5-point Likert scale. Finally, based on consensus (two-thirds majority), scenarios were prioritized and explored for feasibility.

Results
One hundred fourteen experts participated in the study (26 cardiac anesthesiologists, 24 cardiac surgeons, 25 clinical perfusionists, and 39 OR nurses), representing all 16 cardiac surgical centers in the Netherlands. In the first round, 237 scenarios were identified. After eliminating duplicates and grouping similar scenarios, 44 scenarios were scored in round 2, which finally resulted in 13 relevant crisis scenarios with an expert consensus higher than 67%.

Conclusions
Thirteen crisis scenarios relevant to simulation-based team training were identified by an expert panel consisting of all members of the cardiac surgical team. Further research is needed to evaluate the educational value of the respective scenarios.
N-acetyl-5-methoxykynuramine enhance object location and working memory performances via modulating CaMKII, ERK and CREB phosphorylation
Authors: Iwashita Hikaru , Sano Masahiro , Kawaguchi Mari , Chiba Atsuhiko 
Published: March 2023

ObjectivesMelatonin (MEL) has been reported to enhance cognitive performance. Recently, we have demonstrated that a MEL metaboliteN-acetyl-5-methoxykynuramine (AMK) promoted the formation of long-term object recognition memory more potently than MEL. Here, we examined the effects of 1 mg/kg MEL and AMK on both object location memory and spatial working memory. We also investigated the effects of the same dose of these drugs on relative phosphorylation/activation levels of memory-related proteins in the hippocampus (HP), the perirhinal cortex (PRC) and the medial prefrontal cortex (mPFC).MethodsObject location memory and spatial working memory were assessed using the object location task and the Y-maze spontaneous alternation task, respectively. Relative phosphorylation/activation levels of memory-related proteins were assessed using western blot analysis.ResultsAMK, as well as MEL, enhanced object location memory and spatial working memory. AMK increased the phosphorylation of cAMP-response element-binding protein (CREB) in both the HP and the mPFC 2 h after the treatment. AMK also increased the phosphorylation of extracellular signal-regulated kinases (ERKs) but decreased that of Ca2+/calmodulin-dependent protein kinases II (CaMKIIs) in the PRC and the mPFC 30 min after the treatment. MEL increased CREB phosphorylation in the HP 2 h after the treatment, whereas no detectable changes in the other proteins examined were observed.ConclusionThese results suggested the possibility that AMK exerts stronger memory-enhancing effects than MEL by more remarkably altering the activation of memory-related proteins such as ERKs, CaMKIIs and CREB in broader brain regions, including the HP, mPFC and PRC, compared to MEL.
I see you, you see me: the impact of social presence on social interaction processes in autistic and non-autistic people
Authors: Freeth Megan , Morgan Emma J. 
Published: March 2023

Environments that require social interaction are complex, challenging and sometimes experienced as overwhelming by autistic people. However, all too often theories relating to social interaction processes are created, and interventions are proposed, on the basis of data collected from studies that do not involve genuine social encounters nor do they consider the perception of social presence to be a potentially influential factor. In this review, we begin by considering why face-to-face interaction research is important in this field. We then discuss how the perception of social agency and social presence can influence conclusions about social interaction processes. We then outline some insights gained from face-to-face interaction research conducted with both autistic and non-autistic people. We finish by considering the impact of social presence on cognitive processes more broadly, including theory of mind. Overall, we demonstrate that choice of stimuli in studies assessing social interaction processes has the potential to substantially alter conclusions drawn. Ecological validity matters and social presence, in particular, is a critical factor that fundamentally impacts social interaction processes in both autistic and non-autistic people.
This article is part of a discussion meeting issue ‘Face2face: advancing the science of social interaction’.
Gesture, spatial cognition and the evolution of language
Authors: Levinson Stephen C. 
Published: March 2023

Human communication displays a striking contrast between the diversity of languages and the universality of the principles underlying their use in conversation. Despite the importance of this interactional base, it is not obvious that it heavily imprints the structure of languages. However, a deep-time perspective suggests that early hominin communication was gestural, in line with all the other Hominidae. This gestural phase of early language development seems to have left its traces in the way in which spatial concepts, implemented in the hippocampus, provide organizing principles at the heart of grammar.
This article is part of a discussion meeting issue ‘Face2face: advancing the science of social interaction’.