bluuebunny/crossref_metadata_2025_split huggingface dataset:
Production of bio‐based concrete water reducers from renewable resources: a review
Authors: Johnson Anthony Tosan , Sosa Dennise , Arredondo Rosa , Li Hongwei , Yuan Zhongshun , Xu Chunbao (Charles) 
Published: April 2023

AbstractConcrete is a valuable construction material with high mechanical strength and durability, used extensively in the construction industry. It is produced by mixing sand, stones, cement, and water in different proportions depending on the desired quality of the final product. Water reducers are additional chemical ingredients used in concrete to reduce the quantity of water required in the concrete mixture. When added to concrete, water reducers increase the workability and flowability of concrete in the freshly mixed state and improve the mechanical strength and durability of the final hardened product. This review paper describes the different types and applications of concrete water reducers used in the construction industry including their working mechanisms and fluidity effects on concrete properties. It discusses the production of synthetic and bio‐based concrete water reducers and reviews the present challenges involved in the preparation of bio‐based concrete water reducers from renewable resources. © 2023 Society of Industrial Chemistry and John Wiley & Sons Ltd.
Severe graft‐versus‐host disease post allogeneic hematopoietic stem cell transplantation due to loss of HLA heterozygosity in recipient lymphocytes after full graft rejection
Authors: Xue Song , Miao Lili , Gong Zimu , Huang Wenqiu , Zhang Yongping , Liu Fuhong , Wang Jingbo 
Published: April 2023

AbstractGerm cell tumors complicated by hematological malignancy (HM) are a rare clinical phenomenon. Allogeneic hematopoietic stem cell transplantation (allo‐HSCT) is a potentially effective therapy, but graft‐versus‐host disease (GVHD) is a life‐threatening complication. We report a case of a 13‐year‐old female patient diagnosed with germ cell tumors followed by acute lymphoblastic leukemia. After chemotherapy, she received allo‐HSCT and her chimerism rate decreased rapidly to near zero by 6 months without evidence of HM recurrence. However, she developed severe, multiorgan GVHD‐like manifestations. DNA analysis revealed the pathogenesis of GVHD to be loss of HLA heterozygosity in recipient hematopoietic cells.
UHPLC‐Orbitrap‐Fusion‐TMS‐Based Metabolomics Study of Phenylpropionamides in the Seed of Cannabis sativa L. against Alzheimer's Disease
Authors: Wu Dan‐Dan , Liu Yan , Guan Wei , Pan Juan , Kuang Hai‐Xue , Yang Bing‐You 
Published: April 2023

AbstractPhenylpropionamides in the seed of Cannabis sativa L. (PHS) have a protective effect on neuroinflammation and antioxidant activity. In this study, the UHPLC‐Orbitrap‐fusion‐TMS‐based metabolomics approach was used to analyze the serum samples and identify potential biomarkers in Streptozotocin (STZ) induced Alzheimer's disease (AD) rats. The results revealed that primary bile acid biosynthesis and taurine and hypotaurine metabolism were significantly correlated with STZ‐induced AD rats. In addition, the key enzymes in these two pathways were verified at the protein level. The levels of cysteine dioxygenase type I (CDO1), cysteine sulfinic acid decarboxylase (CSAD), cysteamine (2‐aminoethanethiol) dioxygenase (ADO), 7α‐hydroxylase (CYP7A1), and sterol 12α‐hydroxylase (CYP8B1) were the key enzymes affecting the two pathways in AD rats compared with the control group (CON). Furthermore, after a high‐dose group of phenylpropionamides in the seed of Cannabis sativa L. (PHS−H) was administrated, the levels of CDO1, CSAD, CYP7A1, and CYP8B1 were all callback. These findings demonstrate for the first time that the anti‐AD effect of PHS is associated with the regulation of primary bile acid biosynthesis and taurine and hypotaurine metabolism in STZ‐induced AD rats.
A challenging diagnosis for thiamine transporter deficiency anemia (Rogers syndrome) in two young siblings: A rare case report
Authors: Deeb Yara , Martini Nafiza , Ahmad Yara Ahmad , Alkosti Marwa , Hamdan Othman 
Published: April 2023

AbstractWe present these two cases to emphasize the necessity of critical thinking and high suspicion of the disease (Rogers syndrome) to avoid potentially fatal situations due to its rarity and the importance of early treatment.
Zinc Complexes Bearing Dinucleating Bis(imino‐ pyridine)binaphthol Ligands: Highly Active and Robust Catalysts for the Lactide Polymerization
Authors: Santulli Federica , Bruno Filippo , Mazzeo Mina , Lamberti Marina 
Published: April 2023

AbstractWe report the synthesis of new hexadentate ligands bearing imine and pyridine nitrogen neutral donors with a binaphthol backbone. Such ligands have been tailored to have two coordinative pockets thus promoting the formation of bimetallic complexes. By direct reaction of the enantiomerically pure and the racemic ligand with two equivalents of zinc amide precursor, the bimetallic complexes S‐1 and rac‐1 were respectively obtained. Both complexes were highly active in the polymerization of lactides under several reaction conditions, preserving exceptional activities even when working in technical grade melted lactide, thus showing the robustness of the catalysts. Interestingly, complex S‐1 allows the production of either linear or purely macrocyclic PLAs by back‐biting reactions, modifying the reaction conditions. Mechanistic studies have been carried out in NMR‐scale solution to get information on the active species of the polymerization process.
Enhancement in the limit of detection of lab‐on‐chip microfluidic devices using functional nanomaterials
Authors: Vaishampayan Vijay , Kapoor Ashish , Gumfekar Sarang P. 
Published: April 2023

AbstractTechnological developments in recent years have witnessed a paradigm shift towards lab‐on‐chip devices for various diagnostic applications. Lab‐on‐chip technology integrates several functions typically performed in a large‐scale analytical laboratory on a small‐scale platform. These devices are more than the miniaturized versions of conventional analytical and diagnostic techniques. The advances in fabrication techniques, material sciences, surface modification strategies, and their integration with microfluidics and chemical and biological‐based detection mechanisms have enormously enhanced the capabilities of these devices. The minuscule sample and reagent requirements, capillary‐driven pump‐free flows, faster transport phenomena, and ease of integration with various signal readout mechanisms make these platforms apt for use in resource‐limited settings, especially in developing and underdeveloped parts of the world. The microfluidic lab‐on‐a‐chip technology offers a promising approach to developing cost‐effective and sustainable point‐of‐care testing applications. Numerous merits of this technology have attracted the attention of researchers to develop low‐cost and rapid diagnostic platforms in human healthcare, veterinary medicine, food quality testing, and environmental monitoring. However, one of the major challenges associated with these devices is their limited sensitivity or the limit of detection. The use of functional nanomaterials in lab‐on‐chip microfluidic devices can improve the limit of detection by enhancing the signal‐to‐noise ratio, increasing the capture efficiency, and providing capabilities for devising novel detection schemes. This review presents an overview of state‐of‐the‐art techniques for integrating functional nanomaterials with microfluidic devices and discusses the potential applications of these devices in various fields.
Synthesis and characterization of synthetic lubricants based on dibasic acid
Authors: El‐Shazly Reham I. , Haseeb Mohamed E. , Nassar Amal M. , Ahmed Nehal S. 
Published: April 2023

AbstractSynthetic esters have long been used in a variety of applications due to their excellent thermal stability, excellent cleanliness, natural lubricity, and polarity. In the present work, we aimed to prepare some synthetic base oils through preparation of different dibasic esters by esterification of dicarboxylic acids (adipic acid and azelaic acid) with different linear alcohols (hexanol, octanol, and decanol) and branched alcohol (2‐ethyl hexanol) at 120°C. The reaction yield ranges between 85% and 94%. Fourier‐transform infrared spectroscopy (FT‐IR) and proton nuclear magnetic resonance (1H‐NMR) spectroscopy were used to analyze the structures of the produced compounds. Using thermo gravimetric analysis (TGA), the heat stability of the produced esters was determined, and it was found that the prepared esters have high thermal stability. The degradation of the prepared esters takes place in the range between 300 and 600°C. The rheological behaviour of prepared esters shows Newtonian behaviours, which means that Newtonian fluids obey viscosity Newton's law. The viscosity is independent of the shear rate. The results showed that the lubricity properties, based on their pour point, flash point, and oxidation stability of the esters, were significantly affected by the linear and branched alcohols used. There is a slight increase in kinematic viscosity and viscosity index values with decreasing the internal chain length of the dibasic acid. The esters which were based on adipic acid such as C1 exhibited maximum values of VI: 187 compared to those which were based on azelaic acid such as F1 with VI: 182. Viscosity and viscosity index increases with increasing the number of carbon atoms of the used mono‐ol alcohols. Using branched alcohols gave almost the same viscosity results compared to using linear alcohol with the same number of carbons. Almost all prepared esters give pour point results ≤ −30°C.
Insights into the role of water concentrations on nanomechanical behavior of type I collagen‐hyaluronan interfaces in annulus fibrosus: A molecular dynamics investigation
Authors: Bhattacharya Shambo , Dubey Devendra K. 
Published: April 2023

AbstractMulti‐faceted deformation capabilities of Annulus Fibrosus (AF) results from an intricate mechanical design by nature. Wherein, organization and interactions between the constituents, collagen type I (CI), collagen type II (C2), hyaluronan, aggrecan, and water are instrumental. However, mechanisms by which such interactions influence AF mechanics at tissue‐scale is not well understood. This work investigates nanoscale interfacial interactions between CI and hyaluronan (CI‐H) and presents insights into their influence on tissue‐scale mechanics of AF. For this, three‐dimensional molecular dynamics (MD) simulations of tensile and compressive deformation are conducted on atomistic model of CI‐H interface at 0%, 65%, and 75% water concentrations (WC). Results show hyaluronan lowers local hydration around CI component of interface, owing to its hydrophilic nature. Analyses show that increase in WC from 65% to 75% leads to increased interchain sliding in hyaluronan, which further lowers tensile modulus of the interface from 2.1 GPa to 660 MPa, contributing to softening observed from outer to inner AF. Furthermore, increase in WC from 65% to 75%, shifts compressive deformation from buckling‐dominant to non‐buckling‐dominant which contributes towards lower radial bulge at inner AF. Findings provide deeper insights into mechanistic interactions and mechanisms at fundamental length‐scale which influence the AF structure‐mechanics at tissue‐scale.
Harvesting Green Hydrogen by Self‐Propelling Built‐in Electric Field Photo/Electro‐catalytic Performance of DyCrO3Nanoparticles Developed by Reverse Microemulsion Route
Authors: Khan Huma , Mehtab Amir , Ahmed Jahangeer , Lofland Samuel E. , Ramanujachary Kandalam V. , Ahmad Tokeer 
Published: April 2023

AbstractHerein, we demonstrate photocatalytic hydrogen generation and the role of sacrificial agents using multi‐functional DyCrO3nanoparticles by virtue of built‐in electric field (BIEF) which helps in increasing charge separation efficiency. DyCrO3nanoparticles synthesized by the low‐cost reverse micellar approach showed high surface area (17.9 m2/g) and band‐gap (2.01 eV) in visible region. Sacrificial agent assisted photocatalytic H2production of DyCrO3nanoparticles exhibited higher selectivity towards Na2S/Na2SO3by producing H2evolution of 347 μand apparent quantum yield of 6.8% than ethylene glycol and triethanolamine, respectively. The oxygen defects (observed in X‐ray photoelectron spectroscopic studies) and BIEF both synergistically helped in enhancing photocatalytic activity. Moreover, the multifunctional competence of DyCrO3nanoparticles was observed in electrocatalytic water splitting. DyCrO3nanoparticles found to be active HER and OER electrocatalyst with low overpotential and great durability.
Vitamin D status and latitude predict brain lesions in adrenoleukodystrophy
Authors: van Haren Keith P. , Wilkes Jacob , Moser Ann B. , Raymond Gerald V. , Richardson Troy , Aubourg Patrick , Collins Timothy W. , Mowry Ellen M. , Bonkowsky Joshua L. 
Published: April 2023

AbstractObjectivesApproximately 40% of boys with X‐linked adrenoleukodystrophy (ALD) develop inflammatory demyelinating brain lesions (cerebral ALD, cALD) and are at risk for death or severe disability. Risk factors for cALD are poorly understood. Our objective was to evaluate whether vitamin D status, which influences immune function, is associated with risk for cALD.MethodsWe used two independent cohorts to assess whether low vitamin D status is correlated with cALD. We used complementary proxies for vitamin D status: plasma 25‐hydroxyvitamin D levels and latitude. In our first cohort, we measured 25‐hydroxyvitamin D in biobanked plasma samples from ALD boys with initially normal brain MRIs followed at two expert centers. In a second cohort, we measured latitude (using home ZIP code) among ALD boys identified in a national administrative database (PHIS) covering 51 US pediatric hospitals. We used logistic regression models to estimate the odds of developing cALD in each cohort.ResultsIn the first cohort, we identified 20 ALD boys with a total of 53 plasma sample timepoints who met inclusion criteria; 50% (n = 10) subsequently developed cALD. Average 25‐hydroxyvitamin D levels were lower among boys who developed cALD than those who did not (median 28.9 vs 36.6 ng/ml); p = 0.019. For each 10 ng/mL decrease in 25‐hydroxyvitamin D, the odds ratio for developing cALD was 6.94; p = 0.044. In the second cohort, we identified 230 ALD boys across 28 states; 57% of boys (n = 132) developed cALD. Each 2° increase in latitude conferred an odds ratio of 1.17 (95% confidence interval, 1.01, 1.35); p = 0.036 for developing cALD.ConclusionsUsing independent cohorts, we found that ALD boys with lower pre‐morbid plasma levels of 25‐hydroxyvitamin D, or more northerly latitude of residence, were more likely to develop cALD. These findings offer complementary lines of evidence that vitamin D and/or ultraviolet light exposure influence cALD risk.
Uncovering the Role of Electronic Doping in Lead‐free Perovskite (CH3NH3)2CuCl4‐xBrx and Solar Cells Fabrication
Authors: Gassara Mahdi , Hemasiri Naveen Harindu , Kazim Samrana , Costantino Ferdinando , Naïli Houcine , Ahmad Shahzada 
Published: April 2023

AbstractLead halide perovskites are attractive pigments to fabricate solar cells in the laboratory, owing to their high power conversion efficiency. However, given the presence of Pb, such materials also have a high level of toxicity and are carcinogenic for humans and aquatic life. Arguably, this hampers their acceptability for immediate commercialization. This study entails the synthesis, optoelectronic properties, and photovoltaic parameters of two‐dimensional copper‐based perovskites as an environmentally benign alternative to lead‐based perovskites. The perovskites – (CH3NH3)2CuCl4‐xBrx with x=0.3 and 0.66 – are derivatives of the stable (CH3NH3)2CuCl4. The single crystals and powders diffractograms suggest compositions with variations in Cl/Br ratio and dissimilar bromine localization in the inorganic framework. The copper mixed halide perovskite exhibits a narrow absorption with a bandgap of 2.54–2.63 eV related to the halide ratio disparity (crystal color variation). These findings demonstrate the impact of halides to optimize the stability of methylammonium copper perovskites and provide an effective pathway to design eco‐friendly perovskites for optoelectronic applications.
Maternal negative affect moderates behavioral and physiological synchrony in Latinx and Black mother–child dyads
Authors: Hale Molly E. , Morrow Kayley E. , George Andrea M. , Gayer Amy , Caughy Margaret O. , Suveg Cynthia 
Published: April 2023

AbstractPositive behavioral synchrony (PBS) between mothers and children involves the bidirectional exchange of verbal and nonverbal communication. Respiratory sinus arrhythmia (RSA) synchrony reflects the concordance between mother–child physiological states. Both PBS and RSA synchrony can be undermined by psychopathology symptoms. Latinx and Black families may experience contextual stressors that contribute to heightened symptoms of psychopathology, yet minimal research has examined relations between psychopathology symptoms with PBS and RSA synchrony in these families. The present study assessed associations between maternal depressive and child internalizing symptoms, mother and child negative affect (NA), and PBS and RSA synchrony in a sample of 100 Latina and Black mothers (Mage = 34.48 years, SD = 6.39 years) and their children (Mage = 6.83 years, SD = 1.50 years). Dyads engaged in a video‐recorded stress task where RSA was collected continuously. Videos were later coded for PBS and mother and child NA. Mothers reported on their depressive and child's internalizing symptoms. Maternal NA was associated with weak PBS and negative RSA synchrony. Neither depressive and internalizing symptoms nor child NA were associated with PBS or RSA synchrony. Results highlight the potency of maternal NA on behavioral and physiological synchrony in Latinx and Black families.
Construction of a web‐based dynamic nomogram for predicting the prognosis in acute heart failure
Authors: Gao Rongrong , Qu Qiang , Guo Qixin , Sun Jinyu , Liao Shengen , Zhu Qingqing , Zhu Xu , Cheang Iokfai , Yao Wenming , Zhang Haifeng , Li Xinli , Zhou Yanli 
Published: April 2023

AbstractAimsThe early identification and appropriate management may provide clinically meaningful and substained benefits in patients with acute heart failure (AHF). This study aimed to develop an integrative nomogram with myocardial perfusion imaging (MPI) for predicting the risk of all‐cause mortality in AHF patients.Methods and resultsProspective study of 147 patients with AHF who received gated MPI (59.0 [47.5, 68.0] years; 78.2% males) were enrolled and followed for the primary endpoint of all‐cause mortality. We analysed the demographic information, laboratory tests, electrocardiogram, and transthoracic echocardiogram by the least absolute shrinkage and selection operator (LASSO) regression for selection of key features. A multivariate stepwise Cox analysis was performed to identify independent risk factors and construct a nomogram. The predictive values of the constructed model were compared by Kaplan–Meier curve, area under the curves (AUCs), calibration plots, continuous net reclassification improvement, integrated discrimination improvement, and decision curve analysis. The 1, 3, and 5 year cumulative rates of death were 10%, 22%, and 29%, respectively. Diastolic blood pressure [hazard ratio (HR) 0.96, 95% confidence interval (CI) 0.93–0.99; P = 0.017], valvular heart disease (HR 3.05, 95% CI 1.36–6.83; P = 0.007), cardiac resynchronization therapy (HR 0.37, 95% CI 0.17–0.82; P = 0.014), N‐terminal pro‐B‐type natriuretic peptide (per 100 pg/mL; HR 1.02, 95% CI 1.01–1.03; P < 0.001), and rest scar burden (HR 1.03, 95% CI 1.01–1.06; P = 0.008) were independent risk factors for patients with AHF. The cross‐validated AUCs (95% CI) of nomogram constructed by diastolic blood pressure, valvular heart disease, cardiac resynchronization therapy, N‐terminal pro‐B‐type natriuretic peptide, and rest scar burden were 0.88 (0.73–1.00), 0.83 (0.70–0.97), and 0.79 (0.62–0.95) at 1, 3, and 5 years, respectively. Continuous net reclassification improvement and integrated discrimination improvement were also observed, and the decision curve analysis identified the greater net benefit of the nomogram across a wide range of threshold probabilities (0–100% at 1 and 3 years; 0–61% and 62–100% at 5 years) compared with dismissing the included factors or using either factor alone.ConclusionsA predictive nomogram for the risk of all‐cause mortality in patients with AHF was developed and validated in this study. The nomogram incorporated the rest scar burden by MPI is highly predictive, and may help to better stratify clinical risk and guide treatment decisions in patients with AHF.
Tunable magnetophoretic method for distinguishing and separating wear debris particles in an Fe‐PDMS‐based microfluidic chip
Authors: Zhao Kai , Wei Yunman , Zhao Penglu , Kong Dejian , Gao Tianbo , Pan Xinxiang , Wang Junsheng 
Published: April 2023

AbstractWear debris analysis provides an early warning of mechanical transmission system aging and wear fault diagnosis, which has been widely used in machine health monitoring. The ability to detect and distinguish the ferromagnetic and nonmagnetic debris in oil is becoming an effective way to assess the health status of machinery. In this work, an Fe‐poly(dimethylsiloxane) (PDMS)‐based magnetophoretic method for the continuous separation of ferromagnetic iron particles by diameter and the isolation of ferromagnetic particles and nonmagnetic particles with similar diameter by type is developed. The particles experience magnetophoretic effects when passing through the vicinity of the Fe‐PDMS where the strongest gradient of the magnetic fields exists. By choosing a relatively short distance between the magnet and the sidewall of the horizontal main channel and the length of Fe‐PDMS with controlled particles flow rate, the diameter‐dependent separation of ferromagnetic iron particles, that is, smaller than 7 µm, in the range of 8–12 µm, and larger than 14 µm, and the isolation of ferromagnetic iron particles and nonmagnetic aluminum particles based on opposite magnetophoretic behaviors by types are demonstrated, providing a potential method for the detection of wear debris particles with a high sensitivity and resolution and the diagnostic of mechanical system.
Evaluation of environmental sustainability of the construction and operation phases of man‐made lakes; A case study: Chitgar Lake
Authors: Asadollahfardi Gholamreza , Noghani Salman , Panahandeh Azadeh , Samadi Amirmohsen , Asnaashari Ehsan 
Published: April 2023

AbstractEnvironmental sustainability of the Chitgar Lake construction project in Tehran, Iran, was evaluated by a life cycle assessment (LCA) method in two phases of construction and operation using SimaPro 8.2.3 software. The results of analysis by Centre voor Milieukunde Leiden (CML) and IMPACT methods demonstrated that during the construction and operation (assuming 80 years of operation) phases of the lake 0.102 and 0.141 Mt of CO2eq (affects global warming), 0.015 and 0.021 Mt of 1,4‐dichlorobenzene (DB)eq (results in toxicity for humans), 657.155 and 807.425 tons of SO2eq (leads to acidification), 150.123 and 69.374 tons of eq (causes eutrophication), 1597 and 2265 terajoules of primary energy (damages the resources), 0.1 and 0.138 Mt of CO2eq (impacts on climate change), 18205330.45 and 11424387.32 potentially disappeared function (PDF) × m2 × yr (harms the quality of the ecosystem), and 165.37 and 104.94 disability‐adjusted life year (DALY) (threats the human health) are caused, respectively. Electricity consumption has the greatest environmental impact on the operation phase of the lake. Furthermore, the operation phase of the lake is more harmful to the environment and human health compared to the construction phase.