bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparative Study of Five Blood Cardioplegia Systems
Authors: Byrne Christopher J. , Bednarski Allison J. , Beckley Philip D. 
Published: August 2023

Five blood cardioplegia delivery systems (Gish Straight Shot, Sorin BCD Advanced, A vecor MYOtherm, Baxter-Bentley HE-30, and Baxter-Bentley HE-30 Gold) were evaluated with respect to ease of rapid priming, coefficient of heat exchange, pressure drop, bubble trap capacity, and priming volume. Each system was placed in a roller pump circuit consisting of source and collection reservoirs, cardioplegia solution, and pre-post system pressure and temperature monitoring sites. A trial was performed on four units of each brand by first priming the circuit with 0.9% NaCI at 200 ml/min. Bovine blood (hematocrit 22%) was then introduced simulating use during bypass. Pressure drops across the heat exchanger were measured at flows of 200, 300, and 400 ml/min and at temperatures of 37°, 19°, and 4°C. Coefficient of heat exchange was determined at 300 ml/min flow. Air was infused into the system to quantify the bubble trap capacity of the heat exchanger module. Priming volume of the entire system and of the heat exchanger module were determined by draining each into a graduated cylinder.
The Sorin system had significantly less priming volume when compared to all others. The HE-30 units had significantly higher heat exchange coefficients compared to all other systems. Variability was noted in pressure drop at the highest flows and lowest temperatures.
ÖGD-Expertise in die Forschung bringen: eine Workshop-Reihe
zu vektorübertragenen und weiteren zoonotischen
Erkrankungen
Authors: Schmitz Saskia Rebecca , Klier Christiane , Princk Christina , Meyer-Schlinkmann Kristin , Mylius Maren , Dressel Kerstin , Kleele Sebastian , Winter Fenja , Campe Amely , Rissland Jürgen , Sternjakob Anna , Dobler Gerhard , Oehme Rainer , Ulrich Rainer Günter , Dreesman Johannes 
Published: August 2023

ZusammenfassungForschungsverbünde müssen die Bedürfnisse und
Anforderungen des Öffentlichen Gesundheitsdienstes (ÖGD)
verstehen, um geeignete Werkzeuge und Strategien zu entwickeln, die ihn bei der
Risikoidentifikation und - kommunikation unterstützen können.
Die Forschungsverbünde für zoonotische Infektionen RoBoPub,
Q-GAPS, TBENAGER und ZooBoCo haben ein Workshop-Format genutzt, um die Expertise
des ÖGD in ihre Arbeit einzubinden. Wir stellen die Ergebnisse der drei
Workshops dar, die im Rahmen des Jahreskongresses des Bundesverbandes der
Ärzt:innen des ÖGD in den Jahren 2018, 2019 und 2022 mit
Vertreter:innen des ÖGD durchgeführt wurden. Jeder Workshop
dauerte 90 Minuten und wurde im World-Café-Format mit jeweils
unterschiedlichen Themenschwerpunkten abgehalten. Im ersten Workshop wurden
Probleme, Ziele, Lösungen und Anforderungen an die
Forschungsverbünde bezüglich der beruflichen und privaten
Exposition gegenüber Nagetier-übertragenen Infektionen, sowie
dem Einsatz von Risikokarten zusammengetragen. Im zweiten und dritten Workshop
wurden Risikokommunikationsstrategien anhand von Ausbruchsszenarien oder
Szenarien mit neu identifizierten Risikogebieten erarbeitet. An jedem Workshop
nahmen mehr als 20 Personen teil, von denen je mindestens die Hälfte in
kommunalen Gesundheitsämtern tätig war. Die Workshops ergaben,
dass von den Forschungsverbünden vor allem praxisbezogenes,
zielgruppenspezifisches Material für die Risikokommunikation erwartet
wurde. In der Erfahrung der Teilnehmenden ist der direkte Kontakt zu Betroffenen
in der Risikokommunikation essentiell. Um Aufmerksamkeit für die
Risikolage zu erzeugen und Kontakt zu den Zielgruppen herzustellen,
können soziale Medien traditionelle Medien ergänzen, vor allem
bei schwer erreichbaren Zielgruppen. Ihr Einsatz sollte jedoch vorab
sorgfältig abgewogen und geplant werden. Das Workshop-Format erwies sich
als geeignet, um den ÖGD in die Forschungsvorhaben einzubinden. Die
Anforderungen des ÖGD konnten in den Verbünden in Form eines
Leitfadens, eines Risikomanagementplans und Erregersteckbriefen umgesetzt
werden. Bei der Integration des ÖGD sollte bedacht werden, wie die
Arbeitsbelastung für ÖGD-Vertreter:innen gering gehalten und wie
ein passendes Kollektiv erreicht werden kann.
Wettbewerb im Zusammenspiel mit alternativen Steuerungsstrukturen
– Ein konsistenter Steuerungsmix als gesundheitspolitische
Gestaltungsaufgabe
Authors: Greiner Wolfgang 
Published: August 2023

ZusammenfassungWettbewerbliche Systeme sind im Grundsatz ergebnisoffen, d. h. die
Wirkungen zeigen sich oft erst nach einer gewissen Weile, weshalb sie
regelmäßig unabhängig evaluiert und ggf. angepasst
werden sollten. Am Beispiel der sektorübergreifenden Akutversorgung und
des Arzneimittelmarktes wird deutlich, dass die derzeit feststellbaren Defizite
im Gesundheitswesen ihre Ursache vielfach nicht in einem Zuviel an
marktwirtschaftlicher Steuerung haben, sondern (im Gegenteil) in einem
fehlerhaften Ordnungsrahmen mit einem inkonsistenten Steuerungsmix, der zu
Fehlallokationen und damit zu Verschwendung knapper Ressourcen, hohen Kosten und
Überlastung der Beteiligten führt. Wesentliche Anteile von
bestehender Unter-. Über- und Fehlversorgung wären durch eine
adaptive Regulierung in vielen Bereichen wesentlich zu reduzieren.
Glycosyl Triazole Based Pyridinamide/CuI-Catalyzed Coupling of 2-Halobenzamides with Active Methylene Compounds
Authors: Tiwari Vinod K. , Singh Sumit K. , Kumar Sunil , Yadav Mangal S. , Bhattacharya Subrato 
Published: August 2023

AbstractThis report describes a convenient method for the Cu(I)-catalyzed tandem synthesis of dihydrophenanthridinediones and substituted isoquinolinones with the assistance of efficient glycosyl 1,2,3-triazole-based pyridinamide ligands. The catalytic system effectively works for the coupling of N-substituted 2-halobenzamides with various active methylene compounds to form biologically relevant heterocyclic scaffolds in high to excellent yields. The consecutive path of the reaction including intermolecular C–C cross-coupling followed by intramolecular cyclization efficiently takes place at low catalytic loading. These glycosyl triazole-appended pyridinamides were synthesized in good yields by a CuI/DIPEA-mediated regioselective CuAAC click reaction. The notable features of the method include low catalytic loading, the use of cost-effective and biocompatible ligands, high reaction yield, and easily accessible starting materials that make the protocol more versatile.
Imaging Spectrum of Neurological Manifestations of Hemophagocytic Lymphohistiocytosis in Pediatrics: A Case Series
Authors: Sivaramalingam Geethapriya , VK Afiya , Raghavan Bagyam , Govindaraj Jayaraj 
Published: August 2023

AbstractHemophagocytic lymphohistiocytosis (HLH) is an uncommon condition, which can result either from a primary genetic abnormality affecting children or secondary to various conditions like malignancy or infection predominantly in adults. HLH is associated with immune dysregulation, resulting in an uncontrolled overproduction and infiltration of lymphocytes and histiocytes. The infiltration predominantly involves liver, spleen, lymph nodes, and central nervous system. Neuroimaging features on magnetic resonance imaging are highly nonspecific and variable. The most typical findings include periventricular white matter hyperintensities and diffuse atrophy. Ring or nodular enhancing or nonenhancing focal parenchymal lesions may be seen. Here, we present three pediatric cases of primary HLH with a wide spectrum of imaging findings involving cerebral and cerebellar cortex, white matter, deep gray matter, and brain stem. The findings in these patients range from small nonenhancing hemorrhagic lesions and enhancing small lesions to ill-defined mass with mass effect and midline shift. Lesions in deep gray matter including thalamus, basal ganglia, and also brain stem in HLH are rarely described in literature. Early diagnosis of HLH and timely management can improve the course of the disease.
Clinical implication of changes in serum cations and anions on clinical severity in sickle cell disease: A case–control study in a tertiary center
Authors: Patel Suprava , Chandrakar Diksha , Wasnik Preetam Narayan , Nanda Rachita , Mohapatra Eli 
Published: August 2023

Objectives:
Vaso-occlusive crisis in sickle cell disease (SCD) is related to disproportionate serum ions distribution. The objective was to evaluate the influence of changes in serum cations and anions on clinical severity in SCD patients.

Materials and Methods:
The case–control study included 26 SCD cases and 27 apparently healthy control individuals. The cases were further grouped as crisis state and steady state cases. Each participant was assigned a disease severity score. All study participants were evaluated for serum electrolytes, osmolality, calcium, magnesium, phosphorus, total protein, and albumin.

Statistical Analysis:
IBMSPSS version 26 was used for the statistical analysis.

Results:
The mean serum sodium (135.65 mmol/L), chloride (99.88 mmol/L), calcium (2.28 mmol/L), magnesium (0.76 mmol/L), osmolality (285.19 mOsm/kg), and albumin (0.59 mmol/L) were grossly reduced in cases than the control group. The SCD crisis group recorded low serum sodium (p = 0.01), calcium (p = 0.011), total cations (p = 0.023), anions (p = 0.008), and cation–anion ratio (p = 0.041). Of all the cations, serum calcium correlated inversely with disease severity score (r = –0.367, p = 0.033), whereas serum albumin among the serum anions influenced severity the most (r = –0.338, p = 0.046). The cutoff values for serum calcium and albumin were, respectively, 2.41 and 0.63 mmol/L, with a sensitivity of 83.3 and 88.9%. A calculated ratio of serum sodium–albumin revealed a positive relationship with the severity score (r = 0.328, p = 0.05) with a sensitivity of 94.4% for a cutoff value of 208.45.

Conclusion:
Low serum sodium, calcium, albumin, and raised sodium–albumin ratio were linked to the crisis state, and routine estimation of these parameters will help in the early assessment of the clinical severity and initiate appropriate fluid management.
Dose-Related Effectiveness of Andexanet Alfa for Reversal of Apixaban Anticoagulation in a Porcine Polytrauma Model
Authors: Rayatdoost Farahnaz , Braunschweig Till , Schöchl Herbert , Rossaint Rolf , Grottke Oliver 
Published: August 2023

Background Andexanet alfa (andexanet) is a reversal agent for use in patients with life-threatening or uncontrolled bleeding treated with oral factor Xa (FXa) inhibitors. There are limited data on the dose–response relationship of andexanet and FXa inhibitor-related bleeding.
Objective The aim of this study was to assess the dose-related effectiveness of andexanet in reducing blood loss, improving survival, and reversing apixaban anticoagulation in a porcine polytrauma model.
Methods Apixaban was given orally to 40 male pigs for 3 days at a dose of 20 mg/d. On day 3, following bilateral femur fractures and blunt liver injury, animals (n = 8/group) received andexanet (250-mg bolus, 250-mg bolus + 300-mg 2-hour infusion, 500-mg bolus, or 500-mg bolus + 600-mg 2-hour infusion) or vehicle (control). Total blood loss was the primary endpoint. Coagulation parameters were assessed for 300 minutes or until death. Data were analyzed with a mixed-model analysis of variance.
Results Administration of 250-mg bolus + 300-mg infusion, andexanet 500-mg bolus, and 500-mg bolus + 600-mg infusion significantly decreased total blood loss by 37, 58, and 61%, respectively (all p < 0.0001), with 100% survival. Andexanet 250-mg bolus was ineffective in reducing total blood loss (6%) and mortality (63% survival) versus controls. Andexanet 500-mg bolus ± infusion neutralized anti-FXa activity to less than 50 ng/mL. Andexanet neutralization of thrombin generation and thromboelastometry parameters was dose and infusion time dependent.
Conclusion In a porcine polytrauma model with major bleeding on apixaban, andexanet dose dependently decreased anti-FXa activity. Lower anti-FXa levels (<50 ng/mL) with andexanet 500-mg bolus ± infusion were correlated with 60% less blood loss and 100% survival versus controls.
Ab initio calculated dynamic structural factors and optical properties of beryllium along the Hugoniot
Authors: Li Wei-Jie , Zhou Jie , Li Zi , Zhu Yunliang , Hu Han-Dong , Ma Hao , Ma Zhe , Wang Cong , Zhang Ping 
Published: August 2023

Beryllium is an ablator material used in inertial-confinement fusion and hypervelocity impact studies. The thermoelastic properties, structural factors, and optical properties of beryllium are important in these studies. In this paper, the static structural factors, ion–ion dynamic structural factors, adiabatic velocity, and optical properties of beryllium along the Hugoniot were calculated by ab initio simulations. The static structural factors show that beryllium atoms were randomly distributed. The dynamic structural factors extracted the dispersion relation for collective excitation via the scattering function. By collecting the peak position of the dynamic structural factors, the dispersion relation and adiabatic sound velocity were derived by definition. Using the calculated equation of state, the thermoelastic properties and adiabatic sound velocity have been derived. The two calculated methods for adiabatic sound velocity were verified to be equivalent.
Surface science and liquid phase investigations of oxanorbornadiene/oxaquadricyclane ester derivatives as molecular solar thermal energy storage systems on Pt(111)
Authors: Hemauer Felix , Krappmann Daniel , Schwaab Valentin , Hussain Zarah , Freiberger Eva Marie , Waleska-Wellnhofer Natalie J. , Franz Evanie , Hampel Frank , Brummel Olaf , Libuda Jörg , Hirsch Andreas , Steinrück Hans-Peter , Papp Christian 
Published: August 2023

The transition to renewable energy sources comes along with the search for new energy storage solutions. Molecular solar thermal systems directly harvest and store solar energy in a chemical manner. By a suitable molecular design, a higher overall efficiency can be achieved. In this study, we investigate the surface chemistry of oxa-norbornadiene/quadricyclane derivatives on a Pt(111) surface. Specifically, we focus on the energy storage and release properties of molecules that are substituted with ester moieties of different sizes. For our model catalytic approach, synchrotron radiation-based x-ray photoelectron spectroscopy measurements were conducted in ultra-high vacuum (UHV) and correlated with the catalytic behavior in the liquid phase monitored by photochemical infrared reflection absorption spectroscopy. The differences in their spectral appearance enabled us to unambiguously differentiate the energy-lean and energy-rich isomers and decomposition products. Next to qualitative information on the adsorption motifs, temperature-programmed experiments allowed for the observation of thermally induced reactions and the deduction of the related reaction pathways. We analyzed the selectivity of the cycloreversion reaction from the energy-rich quadricyclane derivative to its energy-lean norbornadiene isomer and competing processes, such as desorption and decomposition. For the 2,3-bis(methylester)-substitution, the cycloreversion reaction was found to occur between 310 and 340 K, while the thermal stability limit of the compounds was determined to be 380 K. The larger 2,3-bis(benzylester) derivatives have a lower apparent adsorption energy and a decomposition onset already at 135 K. In the liquid phase (in acetonitrile), we determined the rate constants for the cycloreversion reaction on Pt(111) to k = 5.3 × 10−4 s−1 for the 2,3-bis(methylester)-substitution and k = 6.3 × 10−4 s−1 for the 2,3-bis(benzylester) derivative. The selectivities were of &gt;99% and 98% for the two molecules, respectively. The difference in the catalytic behavior of Pt(111) for both derivatives is less pronounced in the liquid phase than in UHV, which we attribute to the passivation of the Pt(111) surface by carbonaceous species under ambient conditions.
A mini scanning device for profiling charged beams
Authors: Moretto-Capelle P. , Panader E. , Polizzi L. , Champeaux J. P. 
Published: August 2023

In this article, we present the development of a mini scanner device to characterize the full transverse spatial density of a charged particle beam using computed tomography. The profiler consists of a wire mounted on a linear translator that can rotate around the beam. Tests were performed on a millimeter electron beam with 200 eV energy and 100 nA intensity, which allowed us to control and monitor both beam focusing and deflection.
Old English perspectives on the complement shift
Authors: Ojanguren López Ana Elvira 
Published: August 2023

Abstract
This article gathers a motivated inventory of Old English self-manipulative verbs, including Abstain verbs and Refrain verbs, analyses their semantics and syntax and offers diachronic perspectives on the replacement of that-clause complementation with the from + -ing construction. Such perspectives go in two directions. Firstly, the semantics of the that-clause remains intact throughout the change to the from + -ing construction. Secondly, deverbal nominalisations contribute to the semantics and syntax required by the gerund. The main conclusion is that Refrain verbs are exceptional because the competition leading to the Complement Shift does not hold between finite and non-finite clauses, but between finite clauses and deverbal nominalisations. This has two important consequences: the status of derived nominal linked predications must be acknowledged, and deverbal nominalisations must occupy the top of the syntactic ranking of clause linkage.
Language battles in the Linguistic Landscape of a divided capital
Authors: Themistocleous Christiana , Çavuşoğlu Çise , Özkara Melis 
Published: August 2023

Abstract
In this paper we explore multilingual practices in the Linguistic Landscape which are geared towards commercial
goals. We study simultaneously the commercial areas of two conflict-affected communities in Nicosia (Cyprus) which are divided by
a UN-controlled buffer zone. Ledras (Greek-Cypriot) is a street in the south and Arasta (Turkish-Cypriot) is in the north of the
divide. We investigate how these communities’ political economies and ideologies shape language choice in public space and how the
language of the other community, namely Greek or Turkish, is discursively framed as economically valuable or worthless.
Photographs of shopfront signs and a thematic analysis of interviews with shopkeepers revealed that language choice in Nicosia’s
commercial area is highly strategic. We demonstrate that this area is a politically and economically charged space where language
battles, triggered by power relations, differing language hierarchies, ideologies, and political economies, become visible in the LL.
Effects of electron migration and adsorption on the suppression of negative corona discharge in nanoparticle transformer oil: experiments and simulations
Authors: Huang Meng , Zhang Lei , Chen Liangjiong , Sheng Yifan , Niu Mingkang , Lv Yuzhen , Qi Bo 
Published: August 2023

Abstract
SiO2 and TiO2 nanofluids (NFs for short) were prepared, and a series of DC corona discharge tests were carried out under needle-plate electrode on both NFs and base oil, using the luminous area and pulse current to characterize the negative corona discharge characteristics. The trap distribution characteristic as well as the mobilities of positive and negative ions of the two types of NFs and base oil were measured. A kind of new corona discharge simulation model was established, and the effects of shallow traps and electrons adsorbed by nanoparticles were considered in the simulation model. The corona discharge was simulated under the needle-plate electrode and the simulation results were compared with the corona discharge characteristics obtained from the tests. Furthermore, the effects of shallow trap and electron adsorbed by nanoparticles on space charge and electric field distribution as well as field ionization in transformer oil were analyzed respectively, revealing the mechanism that nanoparticles regulate the carrier migration process to suppress the negative corona discharge of transformer oil.
Design analysis and experimental validation of relaxation oscillator-based circuit for R–C sensors
Authors: Idris Wani Mohamad , Saquib Khan Sadan , Jan Benish , Ahmad Meraj , Shojaei Baghini Maryam , Somappa Laxmeesha , Malik Shahid 
Published: August 2023

Abstract
Relaxation oscillator-based circuits are widely used for interfacing various resistive and capacitive sensors. The electrical equivalent of most resistive and capacitive sensors is represented using a parallel combination of resistor and capacitor. The relaxation oscillator-based circuits are not suitable for parallel R–C sensors. In this paper, we propose a modified circuit for parallel R–C sensors. The proposed relaxation oscillator-based circuit is based on a dual-slope and charge transfer technique to measure the resistance and capacitance of parallel R–C sensors separately. In addition, the paper provides a detailed analysis and design considerations for the oscillator design by taking into account the various sources of non-idealities. A method to reduce the error by using single-cycle averaging is also introduced. To verify the analyzed design criteria, the circuit is tested with multiple operational amplifiers with different non-idealities. Experimental results verify the performance of the proposed circuit. The circuit is tested for a range from 10 pF to 42 pF and 100 kΩ to 1 MΩ for parallel R–C sensors with an error of less than 1.5%. The circuit is tested with a fabricated water-level sensor. The result confirms the efficacy of the proposed circuit.
Porous carbon nanosheets derived from two-dimensional Fe-MOF for simultaneous voltammetric sensing of dopamine and uric acid
Authors: Chen Shouhui , Zhou Dan , Yu Jingguo , Huang Zhenzhong , Wang Li 
Published: August 2023

Abstract
It is of great significance for electrochemical sensors to simultaneously detect dopamine (DA) and uric acid (UA) related to biological metabolism. In this work, two-dimensional (2D) porous carbon nanosheets (CNS) was prepared as electrocatalysts to improve the sensitivity, the selectivity, and the detection limit of the simultaneous detection. First, 2D amorphous iron-metal organic frameworks (Fe-MOF) was synthesized with Fe3+ and terephthalic acid via a facile wet chemistry method at room temperature. And then, CNS was prepared by pyrolysis and pickling of Fe-MOF. CNS had large specific surface area, good electrical conductivity and lots of carbon defects. The response currents of the CNS modified electrode was larger than those of the control electrodes in the simultaneous determination. The simultaneous determination was measured via differential pulse voltammetry to reduce the effect of capacitive currents on quantitative analysis. The CNS modified electrodes showed high sensitivity and low detection limit for the simultaneous detection of DA and UA. The modified electrodes have been successfully used to detect DA and UA in normal human serum.