bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Association between COVID-19 Vaccination and Hospitalized Situation in Omicron Era, A Retrospective Cohort Study
Authors: Chang Ming-Hung , Liao Kuang-Ming 
Published: July 2023

Abstract
With the emergence of new variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the Omicron variant became the dominant variant of concern and had an impact on hospitalized situation in 2022 worldwide. This retrospective study enrolled hospitalized coronavirus disease 2019 (COVID-19) patients under quarantine in dedicated wards from May 2022 to July 2022. Patients with and without vaccination were matched by propensity scores based on Charlson Comorbidity Index (CCI), gender, quick Sequential Organ Failure Assessment score (qSOFA), absolute lymphocyte count, and specific therapies. We assessed the in-hospital mortality, hospital length of stay (LOS) and dedicated ward LOS. From 209 COVID-19 patients enrolled in the statistical analysis, the overall in-hospital mortality rate was 23.9%, the median hospital LOS was 5 days, and median dedicated ward LOS was 5 days. After matching (n = 63 per group), the in-hospital mortality rate were 25.4% and 27.0% (p = 0.839) in patients with and without vaccination. The hospital LOS and dedicated ward LOS also had no statistical significance. COVID-19 vaccination had insufficient effect on hospitalized COVID-19 patients with old age and multiple comorbidities.
Three-dimensional non-Abelian Bloch oscillations and novel higher-order topological states
Authors: Pan Naiqiao , Chen Tian , Ji Tingting , Tong Xiaoxue , Zhang Xiangdong 
Published: July 2023

Abstract
Exploring novel topological phases of matter is one of the most fascinating research areas because they support some of the most fascinating properties for robust signal transports and wave propagations. Recently, higher-order topological insulators (HOTIs) have been introduced, and were shown to host topological corner states under the theoretical framework of Benalcazar-Bernevig-Hughes (BBH). Here we unveil some novel topological effects in HOTIs by studying the three-dimensional (3D) non-Abelian Bloch oscillations (BOs). In HOTIs, BOs with a multiplied period occur when a force with a special direction is applied due to the effect of the non-Abelian Berry curvature. Along the direction of the oscillations we find a novel higher-order topological state that goes beyond the theoretical framework of BBH. The emergence of such a higher-order topological state coincides with the appearance of the 3D non-Abelian BOs. That is, the 3D non-Abelian BOs can be used as a tool to probe novel higher-order topological states. The phenomena including the 3D non-Abelian BOs and the novel topological states are observed experimentally with designed electric circuit networks. Our work opens up a new way to detect novel topological phases theoretically and experimentally.
Losing tidal wetlands in the midpoint of East Asian-Australasian Flyway in the pasting 100 years
Authors: Chen Wan-Jyun , Chang An-Yu , Lin Chia-Chi , Lin Ruey-Shing , Lee Pei-Fen 
Published: July 2023

Abstract
Migratory shorebirds rely on tidal flats as stopover sites for refueling and wintering. Taiwan is in the middle of the East Asian–Australasian Flyway, where the sandy/muddy shores on the western coast support thousands of migratory birds with important stopover habitats. Among these habitats, tidal flats are the most crucial habitats for shorebird survival. However, in the last century, the landscape has been largely altered for agriculture, aquaculture, and industrial development. To assess the current status of shorebird habitats, we evaluated landscape changes between the 1920s and 2020s based on historical topographic map data, Landsat Archive images, and the Normalized Difference Water Index. Our analysis showed that the area of tidal flats increased before the 1950s but has decreased since the 1980s. The area dropped rapidly from 459.72 km2 to 194.05 km2, and almost 60% of the tidal flat coverage has been lost in the last 60 years. These results indicate that the tidal wetlands in western Taiwan have reached an endangered status, as per the International Union for Conservation of Nature Red List of Ecosystems criteria. Although the decrease in speed seems to have slowed in recent decades, energy and industrial development still threaten tidal wetlands.
Experimental Study on Large Deflections of Perforated Composite Plates
Authors: Demir Ersin 
Published: July 2023

Abstract
An experimental investigation on the large deflection of perforated composite plates is performed in this study. The fabrics of the composite plates are considered as unidirectional and woven. The effects of the variations in diameter, number and location of hole on plates are examined. The effects of the fabrics are also examined. One short edge of the composite plate is clamped, and a constant weight is hanged from the other short edge of the composite plate during the experiments. In order to prove the accuracy of the study done in the experiment, the large deflection analysis of the perforated plates is also made by the SolidWorks simulation program. SolidWorks simulation program is capable of performing large deflection analysis based on finite elements. When the results are examined, the large deflection is less in the woven type fabric and the large deflection value in the multi-hole specimens is higher than the single-hole ones. It is also determined that the increase in the distance of the hole position from the clamped end of the plate reduces the large deflection. As a result of the comparison of linear and nonlinear calculations, it is seen that non-linear calculation should be preferred especially if the applied force is large. When the experimental and the numerical results are compared, it is seen that the obtained results are compatible.
Active Vitamin D analog and SARS-CoV-2 IgG after BNT162b2 vaccination in patients with hemodialysis
Authors: Nakashima Akio , Yamamoto Izumi , Kobayashi Arisa , Kimura Keita , Yaginuma Tatsuhiro , Nishio Shinichiro , Kato Kazuhiko , Kawai Rena , Horino Tetsuya , Ohkido Ichiro , Yokoo Takashi 
Published: July 2023

Abstract

Vaccination is the effective strategy for coronavirus disease 2019 (COVID-19). However, few studies have investigated the association between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immunoglobulin (Ig)G and vitamin D. This study aimed to investigate the association between SARS-CoV-2 IgG and active vitamin D analogs in hemodialysis patients. Blood samples were collected four times: before vaccination and 30, 60, and 90 days after vaccination. We analyzed patients who were supposed to receive a third vaccination, BNT162b2 (Pfizer©). A total of 418 patients were enrolled. The mean age was 71.1 ± 12 years. Almost two thirds of the patients were prescribed active vitamin D analogs. The distribution of SARS-CoV-2 IgG before vaccination was 235 (93–454) AU/ml. The changes in the IgG after vaccination were 15582 (7233–36445) AU/ml at 30 days, 13184 (5910–30529) AU/ml at 60 days, and 10239 (4566–24971) AU/ml at 90 days. The SARS-CoV-2 IgG level of patients with active vitamin D analog use was higher in all periods. After multiple regression analyses, active vitamin D analog use was found to be associated with higher SARS-CoV-2 IgG levels from pre-vaccination to 90 days post-vaccination. This study showed an association between higher SARS-CoV-2 IgG and active vitamin D analog in hemodialysis patients.
Causal relationship between rheumatoid arthritis and thyroid dysfunction: A two-sample Mendelian randomization study
Authors: Sun Junyang , He Dongchu , Xiao Jingjing , Wang Yu 
Published: July 2023

Abstract

BackgroundGrowing evidence has shown that Rheumatoid arthritis (RA) is associated with hyperthyroidism and hypothyroidism.However, the reciprocal cause-and-effect relationship among those three factors has not yet been substantiated.MethodsWe conducted a two-sample Mendelian randomization (TSMR) study with bidirectional analysis. We selected specific single nucleotide polymorphisms (SNPs) associated with rheumatoid arthritis (RA), hyperthyroidism, and hypothyroidism as instrumental variables. Every single nucleotide polymorphism (SNP) was derived from a genome-wide association study conducted specifically on individuals of European ancestry. For this study, the primary approach utilized to estimate the reciprocal causal relationship between rheumatoid arthritis (RA) and hyperthyroidism or hypothyroidism was the inverse-variance weighting (IVW) method. Finally, the robustness of the results was tested using sensitivity analysis and pleiotropic test.ResultsThe utilization of the IVW method to detect rheumatoid arthritis (RA) revealed an elevated relative risk of hyperthyroidism (OR=1.33, 95% CI=1.17-1.52, P=2.407e-05), as well as a heightened risk of hypothyroidism (OR=1.29, 95% CI: 1.21-1.37, P=3.614e-16). On the flip side, it was observed that hypothyroidism might also elevate the relative risk of developing rheumatoid arthritis (OR=1.57, 95% CI=1.30-1.91, P=4.211e-06). Nevertheless, the analysis using the inverse-variance weighting (IVW) method suggested that there might not be a causal relationship between hyperthyroidism and rheumatoid arthritis (IVW: P=0.769). Finally, a sensitivity analysis was performed to assess the reliability of the results, and it indicated that no pleiotropic effects were observed, further bolstering the validity of the findings.ConclusionThe findings of this study demonstrate a bidirectional causal relationship between genetic susceptibility to rheumatoid arthritis (RA) and an augmented risk of developing hypothyroidism, and vice versa. Moreover, this research establishes a positive causal relationship between genetic susceptibility to rheumatoid arthritis (RA) and an elevated risk of hyperthyroidism. However, it does not provide evidence to support a causal relationship between genetic susceptibility to hyperthyroidism and the development of RA.
Pediatric Pulmonary Multisystem Langerhans cell histiocytosis. Does lung lesion severity affect the outcome?
Authors: Sedky Mohamed , Gohar Seham , Ahmed Sonia , Zaky Iman , Salama Asmaa , Hassanein Omayma , Maher Eslam , ElHaddad Alaa 
Published: July 2023

Abstract
Background
Pulmonary involvement in pediatric multisystem Langerhans cell histiocytosis (PPM LCH) is associated with either low risk (RO-) or high risk (RO+) organs. The nodulo-cystic lung lesions although pathognomonic, yet are very variable in severity and remain a source of controversy in certifying pulmonary LCH diagnosis. The study aimed to examine the prognostic value of clinical respiratory distress and radiological lung lesions severity. This is through associating a CT chest triad of bilateral, extensive and diffuse lesions. It is a retrospective study of 350 LCH patients who received systemic treatment at Children’s Cancer Hospital Egypt during the period from 2007 to 2020.
Results Sixty-seven patients (67/350 − 19.1%) had PPM LCH at presentation. Severe lung lesions were present in 24 of them. The median follow-up period was 61 months (IQR: 3.4 to 8.3). The 5-year overall survival (OS) and event free survival (EFS) was 89% and 56.6% respectively. The EFS, for severe radiological lesions triad was 38% ± 20.7 versus 66% ± 16.2 for non-severe lesions p 0.002, while for concordant chest CT positive / X ray positive lesions 27% ± 22.344 versus discordant CT positive/X ray negative 66% ± 14.7 p 0.001, for clinical respiratory distress 13% ± 13.9 versus none 62% ± 22.9 p < 0.001, for RO- with severe lung lesions 47% ± 30.4 versus RO- without severe lung 69% ± 5.9 p0.04. There was a tendency for the independent prognostic impact of severe lung involvement; aHR = 1.7 (95% CI: 0.92 to 3.13, p = 0.09).
Conclusion Although the lung is a low -risk organ per se in LCH, our study demonstrates a non negligeable prognostic impact of severe lung involvement in the risk stratification of pediatric LCH. This warrants further study and external validation.
Fire-climate-vegetation linkages in quaking aspen forests during the late Holocene
Authors: DeRose R. Justin , Morris Jesse L. 
Published: July 2023

Abstract
Background
- Fire plays an important role in shaping forested systems around the globe. In the western US, fires are a ubiquitous process that affects virtually all forest types. Fires exhibit a wide range of frequencies and severity, which are often associated with forest type. Despite displaying a wide range of traits that would suggest they have evolved with fire, quaking aspen (Populus tremuloides Michx.) has been paradoxically considered resistant to fire (asbestos forests). Unlike many other fire-driven forest types, our understanding of pre-settlement fire behavior in quaking aspen systems is limited. To better understand the frequency and severity of fires in a putatively stable quaking aspen forest, we carefully selected a small, key watershed for sediment coring to reconstruct fire history.
Results
- For the past ~ 4,000 years this basin has been dominated by quaking aspen but also subalpine fir (Abies lasiocarpa (Hook.) Nutt), and their relative composition has shifted inversely over this time period. Large, stand-replacing fires occurred, on average, every 170 years, with individual fire-free intervals ranging from 132–323 years. With such a long fire return interval it is tempting to suggest that the fire regime was controlled from the top down, limited by climate. However, we found that the occurrence of fire was not predictably related to climatic conditions as characterized by cool-season, or warm-season, moisture availability (drought proxies). Rather, fire occurrence was most strongly related to fuel accumulation associated with the predictable successional shift in species dominance from quaking aspen to subalpine fir.
Conclusions
- The characterization of this aspen system as fuel-limited removes some barriers to contemporary fuels management. Unlike in climate-limited systems where managers have little control over fire occurrence due to climatic conditions (e.g., drought), fuel-limited systems are controlled from the bottom up, where the explicit reduction or redistribution of long-term fuel buildup is an effective approach to reducing the likelihood and/or effects of fire in the short-term. In the long-term, managers can expect stand-replacing fires in aspen forests, regardless of their characterization as asbestos forests.
A new camera-trapping device, the “campascope”, to study voles feeding behaviour in field.
Authors: Lisse Hélène , Pinot Adrien 
Published: July 2023

Abstract
Rodents are important animals in science. They are regularly used as study models in many disciplines. However, their behaviours are difficult to observe in the wild due to strong anti-predator behaviour. This is particularly the case for feeding behaviour, which is nevertheless crucial in many field researches, for example to understand voles’ population dynamics.
We developed a tool to test the interaction of wild animals with food. This makes it possible to avoid breeding conditions that can introduce biases, but also to test exogen factors that can modify animals' feeding behaviour (the floral composition of a meadow, distance from a landscape feature, altitude, etc.). Those exogen factors could not be easily tested in captivity. In this study, we tested the device on the fossorial form of water vole. We were able to get the voles into our device and to record good-quality behavioural sequences. In this article, we present the characteristics and use of the device in Arvicola amphibius study, that could also be operating on other small mammal species.
Crystal structure of Synechococcus elongatus 6-4 photolyase suggests a novel repairing mechanism
Authors: Xu Lei , Zhang Wei , Liu Yaqi , Chen Yuanyuan , Ji Zifan , Yao Chengkun , Zhou Yajing , Wang Xiuxiu , Lv Jun , Yan Liang , Zhu Guoping , Zhang Peng 
Published: July 2023

Abstract

SePhrB provides the first structure of prokaryotic 6 − 4 photolyases with 8-HDF as the antenna cofactor, and also the first structure of photolyases with covalently-linked FAD as the catalytic cofactor. It also contains a [4Fe-4S] cluster coordinated with four conserved cysteine residues. Based on the structural analysis and the inspiration of a study on human primase27, we propose that the [4Fe-4S] cluster in SePhrB may participate in electron transfer and trigger DNA disassociation during catalysis. The binding sites for 8-HDF in SePhrB and for 8-HDF, DMRL, FMN, or FAD in other photolyases are in homologous positions, which suggests that 8-HDF may be utilized as the antenna cofactor by the last common ancestor of the antenna cofactor-containing photolyases. The formation of the covalent linkage between FAD and Met399 in SePhrB is light-dependent, which does not require external electron donors. The FAD-methionine photo-adduct in SePhrB is catalytically proficient and stable under aerobic conditions. The novel findings from SePhrB suggest that photolyase family is more complex than expected, which warrant further intensive investigation.
"Assessing the Impact of COVID-19 on Radiology Continuing Medical Education: Challenges and Prospects for Online Learning"
Authors: Abuzaid Mohamed M , Elshami Wiam , Hamd Zuhal Y. , Almohammed Huda I , Alorainy Amal . I 
Published: July 2023

Abstract
Background
This study investigates the impact of the COVID-19 pandemic on the radiology profession, including radiologists and radiographers. It assesses radiology professionals’ challenges in accessing continuing medical education during the pandemic and recommends prospects for CME practices in radiology.
Methods
The data were collected from two predefined groups: radiographers and radiologists. The data were collected through an online survey conducted via Google Forms. A total of 215 radiographers and 65 radiologists participated. The data used in this paper were collected through an online survey administered from November 2022 to January 2023. The survey was structured into two sections. The first section gathered participants' demographic information, and the second section captured the participants' experiences with CME before and during the pandemic.
The results
showed that there had been a shift from face-to-face to online CME events since the outbreak of the COVID-19 pandemic. However, this study’s findings suggest that face-to-face resources are still widely used, despite the restrictions of the pandemic.
Conclusion
The paper concludes that the COVID-19 pandemic has significantly impacted continuing medical education (CME) among radiology professionals, with a shift toward online CME events. The survey findings can help CME providers understand the expectations and requirements of radiology professionals for online medical education. The preference for combined face-to-face and online CME events (blended learning) can define the way for the future development of CME. The paper also highlights the importance of digital learning tools, such as mobile apps and online simulations, in CME programs.
Prospetive evaluation of the risk of compartmental intra-abdominal pressure on mortality in severe acute pancreatitis
Authors: Saad Hassan A , El-Taher Ahmed k , Abo-alella Heba Alhussin , Elsayed Ashraf abdelmonem , Riad Mohamed , Eraky Mohamed E 
Published: July 2023

Abstract

Background
Death in the hospital is significant in patients with severe acute pancreatitis (SAP). They have elevated intraabdominal pressure (IAP), which might result in organ dysfunction. The study's goals were to look at the overall incidence of rising IAP in SAP patients as well as the progression of organ dysfunction and risk mortality factors for higher IAP.
Methods
Between 2020 and 2023, 118 cases of acute pancreatitis were managed in Zagazig University Hospital's intensive care unit (ICU). Patients were categorised into quartiles 1–4. The intravesical technique was used to assess elevated IAP.
Results
Peak IAP, max SOFA score, max APACHE II score, top creatinine, and age, with lactate peak level, were substantially related to IAP and higher in nonsurvivors. The maximal IAP in retrospective groups 1–4 was 7–14, 15–18, 19–24, and 25–33 mmHg, correspondingly, with hospital mortality rates of 10%, 12.5%, 22.2%, and 50%. Respectively, with significant statistics. The highest quality of ICU-free days was 45.7, 38.8, 32.0, and 27.5 days, respectively. Categories one to four have significant statistics.
Conclusion
Greater IAP in SAP cases presented with early organ damage and fewer ICU-free days. IAP is assessed throughout ICU inpatient care to prove the cure rate after decompression.
Patterns and combinations of long-term COVID symptoms in adults and elderly in Southern Brazil: a population-based Sulcovid Study
Authors: Neves Rosália Garcia , Machado Karla Pereira , Vieira Yohana Pereira , Rocha Juliana Quadros Santos , Martins Renata Cristina Silva , Gonzalez Tatiane Nogueira , Duro Suele Manjourany Silva , Saes Mirelle Oliveira 
Published: July 2023

Abstract
Background
The SARS-CoV-2 pandemic has affected a large number of subjects, with high costs in terms of morbidity and mortality. Several reports have described the long-term consequences of COVID-19 and the effects of COVID on multiple systems. To identify the patterns and combinations of symptoms of long-term COVID six to ten months after the initial infection in adults and elderly people in southern Brazil.
Methods
Cross-sectional population-based conducted between December 2020 and March 2021 April. The sample included individuals aged 18 years or older who had a diagnosis of COVID-19 confirmed through the RT-PCR. The presence of 18 symptoms of long COVID was investigated. Long COVID patterns were identified using principal component analysis. The identified patterns were stratified according to the independent variables and presented respective proportions and 95% confidence intervals.
Results
A total of 2,919 individuals were interviewed. The median time after infection was 200 days (± 192.9). The most prevalent symptoms were fatigue/tiredness (19.6%), memory loss (17.7%), loss of attention (13.9%), loss of smell (11.3%), headache (11.7%) and muscle pain (10.1%). Four long-term COVID symptom patterns have been identified, namely: respiratory, neuromusculoskeletal, cognitive and neurosensory. The four patterns showed higher prevalence among females and among interviewees hospitalized during the acute phase of the disease. Respiratory, neuromusculoskeletal and cognitive patterns were higher among respondents with two or more morbidities.
Conclusions
The current study has shown that there are patterns of symptoms after COVID-19. Four distinct patterns of long-term COVID symptoms have been identified six to ten months after initial infection in adults and the elderly. Managers and health professionals can organize services and direct assistance, focusing on higher-risk groups, such as female individuals, hospitalized in the acute phase of the disease and people with chronic diseases.