bluuebunny/crossref_metadata_2025_split huggingface dataset:
Accelerated expansion of the Universe through inert doublet model
Authors: Muhammad Usman , Hassan Ibtehaj 
Published: April 2023

Abstract
Scalar fields are among the possible candidates for dark energy. This paper is devoted to the scalar fields from the inert doublet model, where instead of one as in the standard model, two SU(2) Higgs doublets are used. The component fields of one SU(2) doublet (φ1) act in an identical way to the standard model Higgs while the component fields of the second SU(2) doublet (φ2) are taken to be the dark energy candidate (which is done by assuming that the phase transition in the field has not yet occurred). It is found that one can arrange for late time acceleration (dark energy) by using an SU(2) Higgs doublet in the inert Higgs doublet model, whose vacuum expectation value is zero, in the quintessential regime.
Identification of Fake Messages Using Two PKCs
Authors: Dissanayake W.D.M.G.M. 
Published: April 2023

Abstract

In this paper, two public key cryptosystems are presented and analyzed. The first cryptosystem is an improvement of RSA public key cryptosystem. The second cryptosystem is a novel public key cryptosystem. The encryption/decryption moduli of the introduced new public key scheme is quite different from widely used encryption/decryption moduli by other public key cryptosystems. The introduced new public key cryptosystem based on the exponentiation congruence and use an interesting, computer-friendly modulus:2𝑛. These primitives can be used in protocols for authentication, key exchanges and digital signatures. The introduced two public key cryptosystems are more suitable for highly confidential digital transactions. Both of the cryptosystems are strongly IND secure. The most important thing is, that the both of the public key cryptosystems can identify whether a message is fake or not. The introduced new public key cryptosystem is very collaborative with hash functions such as Whirlpool and SHA-512, because of the modulus 2𝑛.
FeCl3-Promoted Photocatalytic Cleavage of Cα–Cβ Bond in Lignin and Lignin Model to Aromatic Monomers
Authors: Liu Xinwei , Wang Liguo , Sun Fengxia , Sun Yujuan , Zhai Lianjing , Liu Zhanzhan , Liu Jianing 
Published: April 2023

Abstract
Because of the polymerization structure and inherent inert chemical activity of lignin, it is still challenging to depolymerize lignin to obtain valuable chemicals. Here, we present the FeCl3 promoted photocatalytic depolymerization strategy to realize Cα-Cβ oxidative cleavage of lignin model compounds at room temperature. The method generates benzoic acid and phenol compounds with high yield. In addition, the method is effective for the depolymerization of organosolv lignin and affords the corresponding cleavage products of Cα-Cβ bonds.This strategy provides a method of using economical photocatalyst to depolymerize lignin, and provides a reference for the industrial depolymerization of lignin.
A case of repeated in-stent restenosis of coronary artery as a primary manifestation of seronegative antiphospholipid antibody syndrome
Authors: Fu Mingqiang , Chang Shufu , Ma Jianying , Ge Junbo 
Published: April 2023

Abstract
A 65-year-old female with effort chest pain was hospitalized for unstable angina in Janurary, 2015. Coronary angiography revealed sub-total occlusion of proximal left anterior descending (LAD) coronary artery, where a drug-eluting stent was successfully deployed. The patient experienced multiple in-stent occlusion at LAD coronary artery and coronary artery bypass graft (CABG) surgery was advised. Subsequently, severe stenosis of left circumflex (LCX) coronary artery emerged, and the patient suffered persistent in-stent restenosis. Eventually, the patient was diagnosed with seronegative antiphospholipid antibody syndrome and salvaged by immunosuppressants.
Myrislignan Targets Extracellular Signal-regulated Kinase (ERK) and Modulates Mitochondrial Function to Dampen Osteoclastogenesis and Ovariectomy-i nduced Osteoporosis
Authors: Yang Tao , Chen Weiwei , Gan Kai , Wang Chaofeng , Xie Xiaoxiao , Su Yuangang , Lian Haoyu , Xu Jiake , Zhao Jinmin , Liu Qian 
Published: April 2023

Abstract
Background Numerous studies have confirmed that activated osteoclasts cause excessive bone resorption, disrupting bone homeostasis and leading to osteoporosis. Moreover, ERK signaling is the classical pathway related to osteoclast differentiation. Besides, reactive oxygen species (ROS) is mainly from mitochondria, which is closely associated with the differentiation of osteoclasts. Myrislignan (MRL), a natural product derived from nutmeg, has various pharmacological activities. However, its effect on the treatment of osteoporosis is unclear. Therefore, this study mainly investigated whether MRL could inhibit osteoclastogenesis and bone mass loss in ovariectomy (OVX) mice via suppressing mitochondrial function and ERK signaling.Methods Tartrate-resistant and phosphatase (TRAP) assay and bone resorption assay were used to observe the effect of MRL on osteoclastogenesis. Furthermore, we added MitoSOX RED and tetramethyl rhodamine methyl ester (TMRM) staining to test the inhibitory effect of MRL on mitochondria. Quantitative reverse transcription-polymerase chain reaction (qRT-PCR) assay detected whether MRL suppressed the expression of specific genes in osteoclasts. The impact of MRL on mitogen-activated protein kinase (MAPK) and nuclear factor-κB (NF-κB) related proteins was evaluated by western blotting. Besides, a specific ERK agonist LM22B-10 (LM), was added to revalidate the inhibitory effect of MRL on ERK. Moreover, we established an OVX mouse model to assess the therapeutic effect of MRL on osteoporosis in vivo.Results MRL was proven to press osteoclast differentiation and bone resorption function, significantly reducing osteoclastic gene expression. Mechanistically, MRL inhibited the phosphorylation of ERK by suppressing the role of mitochondria, causing the downregulation of nuclear factor of activated T cells 1 (NFATc1) signaling. The experiment result of adding LM further clarified the targeted inhibition effect of MRL on ERK. The results of microscopic computed tomography (Micro-CT) and histology sections of the tibia in vivo indicated that OVX mice had lower bone mass and higher expression of ERK. However, after the MRL application, these results were significantly reversed, suggesting that MRL had a decent anti-osteoporosis effect.Conclusion We saw for the first time that MRL could inhibit ERK signaling by suppressing mitochondrial function, thus reducing OVX-induced osteoporosis. This novel finding could provide a broad prospect for the treatment of osteoporosis.
Long term administration of loquat leaves and their major component, ursolic acid, attenuated endogenous amyloid-β burden and memory impairment
Authors: Iwasa Kensuke , Yagishita Sosuke , Yagishita-Kyo Nan , Yamagishi Anzu , Yamamoto Shinji , Yamashina Kota , Haruta Chikara , Asai Masashi , Maruyama Kei , Shimizu Kuniyoshi , Yoshikawa Keisuke 
Published: April 2023

Abstract
Loquat (Eriobotrya japonica) leaves contain many bioactive components such as ursolic acid (UA) and amygdalin. We investigated the effects of loquat leaf powder and methanol extract in human neuroglioma H4 cells stably expressing the Swedish-type APP695 (APPNL-H4 cells) and C57BL/6J mice. Surprisingly, the extract greatly enhanced cellular amyloid-beta peptide (Aβ) 42 productions in APPNL-H4 cells. Administration of leaf powder increased Aβ42 levels after 3 months and decreased levels after 12 months compared to control mice. Leaf powder had no effect on working memory after 3 months, but improved working memory after 12 months. Administration of UA decreased Aβ42 and P-tau levels and improved working memory after 12 months, similar to the administration of leave powder for 12 months. Amygdalin enhanced cellular Aβ42 production in APPNL-H4 cells, which was the same as the extract. Three-month administration of amygdalin increased Aβ42 levels slightly but did not significantly increase them, which is similar to the trend observed with the administration of leave powder for 3 months. UA was likely the main compound contained in loquat leaves responsible for the decrease in intracerebral Aβ42 and P-tau levels. Also, amygdalin might be one of the compounds responsible for the transiently increased intracerebral Aβ42 levels.
Comparison of Cognitive Workload and Surgical Outcomes between a Three-dimensional and Conventional microscope Macular Hole Surgery
Authors: Kelkar Aditya , S Natarajan , Kothari Akshay , Bolisetty Mounika 
Published: April 2023

Abstract
Background Performing a surgical task subjects the surgeon to multitudinal stressors, especially with the newer 3D technology. The quantum of cognitive workload using this modern surgical system in comparison to the Conventional microscope system remains unexplored. We evaluate the surgeon’s cognitive workload and the surgical outcomes of macular hole(MH) surgery performed on a 3D versus a Conventional microscope operating system.Methods 50 eyes patients with MH undergoing surgery using the 3D or Conventional microscope visualization system. Cognitive workload assessment was done by real-time tools(Surgeons' heart rate [HR] and oxygen saturation[SPO2]) and self-report tool(Surgery Task Load Index[SURG-TLX] questionnaire) of three Vitreoretinal surgeons. Based on the SURG-TLX questionnaire, was performed.Results Of the 50 eyes, 30 eyes and 20 eyes underwent surgery with the Conventional microscope and the 3D system, respectively. No difference was noted in the MH basal-diameter(p = 0.128), total surgical-duration(p = 0.299), internal-limiting membrane(ILM) peel time(p = 0.682), and the final VA(p = 0.515) between the two groups. Both groups showed significant improvement in VA(p < 0.001) with a 90% closure rate at one-month post-surgery. Cognitive workload comparison, the intraoperative HR(p = 0.024), total workload score(P = 0.005), and temporal-demand dimension(p = 0.004) were significantly more in Conventional microscope group as compared to 3D group. In both the groups, the HR increased significantly from the baseline while performing ILM peeling and at the end.Conclusion The surgeon’s cognitive workload is markedly reduced while performing macular hole surgery with a 3D viewing system. Moreover, duration of surgery including ILM peel time, MH closure rates, and visual outcomes remains unaffected irrespective of the operating microscope system.
Fixed-Time Adaptive Fuzzy Control For Uncertain MIMO Nonlinear Systems With Preisach Operator
Authors: Huang Kai , Lai Guanyu , Zhang Yun , Liu Zhi , Wu Yuanqing , Chen C.L.Philip 
Published: April 2023

Abstract
In this paper, a fixed-time adaptive control strategy is developed for the uncertain MIMO nonlinear systems preceded by Preisach operator. For the existing approaches, it is difficult in determining the bound of setting time since unknown hysteresis and interconnected terms coexist in the analysis of stability. To tackle this difficulty, we present a robust fixed-time based approach by adopting the technique of adaptive fuzzy system. Benefiting from the proposed approach, bounded time-varying gains and disturbance-like terms which are from the decomposition of unknown Preisach operators and uncertainties with interconnected terms are accommodated. Furthermore, a type of special Lyapunov function is constructed to ensure that tracking errors converge to presettable intervals respectively, and the closed loop system is proved to be fixed-time stable. To demonstrate the effectiveness of the proposed control approach, a numerical simulation is conducted.
Avulsion of aortic valve commissure in Behcet's disease
Authors: Luo Xian , Yu Tao , Yin Li-Xue , Deng Yan , Zuo Ming-Liang 
Published: April 2023

Abstract
Behçet’s disease (BD) is a chronic systemic inflammatory vasculitis of unknown cause that is recognized worldwide. Cardiovascular system involvement is rare and the most common manifestation of endocardiac involvement in BD is aortic regurgitation (AR). The ultrasonic manifestations of BD- related AR such as echo-free spaces and vegetation-like lesions, can be misdiagnosed with infective endocarditis and bacterial vegetations [1]. This article presents a rare case of avulsion of aortic valve (AV) commissure associated with BD, who experienced hypotension and shock supported with extracorporeal membrane oxygenation.
Hybrids of two destructive subterranean termites established in the field, revealing a potential for gene flow between species
Authors: Li Hou-Feng , Chen Guan-Yu , Huang Shih-Ying , Lin Ming-Der , Chouvenc Thomas , Ching Yung-Hao 
Published: April 2023

Abstract
Hybridization between invasive pest species may lead to significant genetic and economic impacts that require close monitoring. The two most invasive and destructive termite species worldwide, Coptotermes formosanus Shiraki and Coptotermes gestroi (Wasmann), have the potential for hybridization in the field. A three-year field survey conducted during the dispersal flight season of Coptotermes in Taiwan identified alates with atypical morphology, which were confirmed as hybrids of the two Coptotermes species using microsatellite and mitochondrial analyses. Out of 27,601 alates collected over three years, 4.4% were confirmed as hybrid alates, and some advanced hybrids (>F1 generations) were identified. The hybrid alates had a dispersal flight season that overlapped with the two parental species 13 out of 15 times. Most of the hybrid alates were female imply that backcross mating opportunities beyond F1 may primarily be possible through female hybrids. However, the incipient colony growth results from all potential mating combinations suggest that only backcross colonies with hybrid males could sometimes lead to brood development. The observed asymmetrical viability and fertility of hybrid alates may critically reduce the probability of advanced-hybrid colonies being established in the field.
Environmental Impacts of Petroleum Emissions: an Exploration of TOR’s Exposures and Experiences
Authors: Arthur Jones Lewis , Owusu Edward , Amofah Kwaku , Arthur Sonny Davis , Nsiah-Gyabaah Kwasi , Kumah Kwaku 
Published: April 2023

Abstract
This research used the questionnaire to seek the views of 30 respondents from a target population of 200 workers of Tema Oil Refinery. The issues investigated centred on exposures and experiences of TOR's operations in the environment of nearby communities. Both the IBM Statistical Product and Service Solutions (SPSS) version 20 and SmartPLS software were used to calculate the composite reliability test, Cronbach’s alpha, rho A, and Average Variance Extracted (AVE). The analysis covered how item reliability, internal consistency, convergent validity and discriminate validity. R and f squares statistics and the structural equation models could explain the environmental impacts of emissions from refineries. The structural equation model was accessed to establish the relationship between the predictor and impact variables. Collinearity assessments were also done to assess the Variance Inflation Factor (VIF) of the study. The major predictors of environmental impacts for the oil refinery are related to the management of oil storage facilities, the durability of storage tanks and the regularity of the internal inspection of tanks. The major impacts of the refinery activities on the environment were on the quality of air and water.
Online Cognitive Behavioral Stress Management Program for Breast Cancer Patients
Authors: Savaş Esra , Keleş Merve , Tin Ozlem 
Published: April 2023

Abstract

Purpose:Breast cancer is a challenging process that affects the diagnosed people and their social environment psychologically, physiologically, socially,and economically. The main purpose of this study is to investigate the effectiveness of the Online Cognitive Behavioral Stress Management (CBSM) for Cancer program, which is prepared for people diagnosed with cancer to develop coping methods that will enable them to cope with the stress they experience in a healthy and active way.The research question is, whether attending the CBSM program is effective on psychological well- being of breast cancer patients.Material and Method:The study was completed with a total of 35 people, 17 in the experimental group and 18 in the control group. The pretest-posttest results of the experimental and control groups formed according to cancer type and stages were analyzed. The independent sample t-test was used in the comparison of the two groups of experimental and control groups. Paired sample t-test was used to compare the pretest-posttest scores.Results:There was no significant difference in the pre-test and post-test scores of the experimental and control groups in terms of mental adjustment to cancer. There was a significant difference observed between the experimental ,and control groups in the post-test measurements in terms of psychosocial adjustmentto illness, assessment of coping attitudes, depression, hope, state and trait anxiety (p<.001).Conclusion:It can be stated that the Online CBSM program for breast cancer patients can enable them to cope with the stress they experience in a healthy and active way.
Novel host plant use by a specialist insect depends on geographic variation in both the host and herbivore species
Authors: Michielini James , Yi Xianfeng , Brown Leone , Gao Shan Ming , Orians Colin , Crone Elizabeth 
Published: April 2023

Abstract
Understanding the circumstances under which insect herbivores will adopt a novel host plant is a longstanding question in basic and applied ecology. While geographic variation in host use can arise through both differences in herbivore preference and in plant quality, there is a tendency to attribute geographic variation to regional differences in herbivore preference alone. This is especially true for herbivores specialized on one or a few plant species. We compared the contribution of variation in herbivore preference versus host plant quality to regional differences in adoption of a non-native host by a highly specialized herbivore, Euphydryas phaeton. In parts of its range, E. phaeton uses only a native host, Chelone glabra, while in others it also uses an introduced host, Plantago lanceolata. We offered female butterflies from each region the non-native host plant sourced from both regions and compared their oviposition behavior. The non-native host was almost universally rejected by butterflies in the region where only the native plant is used. In the region where butterflies use both hosts, females accepted non-native plants from their natal region twice as often as non-native plants from the other region where they are not used. Acceptance differed substantially among individual butterflies within regions but not among plants within regions. Thus, both individual preference and regional differences in both the insect and non-native host contributed to the geographic variation in different ways. These results highlight that, in addition to herbivore preference, regional differences in plant quality may be important drivers of diet breadth.
Exploratory analysis of injury severity under different levels of driving automation (SAE Level 2-5) using multi-source data
Authors: Wang Dongdong , Ding Shengxuan , Abdel-Aty Mohamed , Barbour Natalia , Wang Zijin , Zheng Ou 
Published: April 2023

Abstract
Vehicles equipped with automated driving capabilities have shown the potential to improve safety and operations. Advanced driver assistance systems (ADAS) and automated driving systems (ADS) have been widely developed to support vehicular automation. Although the studies on the injury severity outcomes that involve automated driving systems are ongoing, there is limited research investigating the difference between injury severity outcomes of the ADAS and ADS vehicles using real-world crash data. To ensure comprehensive analysis, a multi-source dataset that includes the NHTSA crash database (752 cases), CA DMV crash reports (498 cases), and news outlet data (30 cases) is used. Two random parameters multinomial logit models with heterogeneity in the means and variances are estimated to gain a better understanding of the variables impacting the crash injury severity outcome for the ADAS (SAE Level 2) and ADS (SAE Levels 3-5) vehicles. We found that while 56 percent of crashes involving ADAS vehicles took place on a highway, 84 percent of crashes involving ADS took place in more urban settings. The model estimation results indicate that the weather indicators, traffic incident/work zone indicator, differences in the system sophistication that are captured by both– manufacture year and high/low mileage, type of collision, as well as rear and front impact indicators all play a significant role in the crash injury severity. The results offer an exploratory assessment of the safety performance of the ADAS and ADS equipped vehicles in the real-world environment and can be used by the manufacturers and other stakeholder to dictate the direction of their deployment and usage.
Incidence rates of treated mental disorders before and during the COVID-19 pandemic - a nationwide study comparing trends in the period 2015 to 2021
Authors: Jensen Pia , Engdahl Bo , Gustavson Kristin , Lund Ingunn Olea , Pettersen Johanne Hagen , Madsen Christian , Hauge Lars Johan , Knudsen Ann Kristin Skrindo , Reneflot Anne , Brandlistuen Ragnhild Eek , Ask Helga , Nesvåg Ragnar 
Published: April 2023

AbstractBackground:There is a concern that exposure to psychosocial stressors during the COVID-19 pandemic may have led to a higher incidence of mental disorders. Thus, this study aimed to compare trends in incidence rates of depressive disorder, anxiety disorders, obsessive-compulsive disorder (OCD), post-traumatic stress disorder (PTSD), and eating disorders in primary- and specialist health care before (2015-2019) and during the COVID-19 pandemic (2020-2021).Methods:We used aggregated population registry data to calculate incidence rates of mental disorders from primary (The Norwegian Control and Payment of Health Reimbursement Registry (KUHR)) and specialist (The Norwegian Patient Registry (NPR)) health care. The analyses included all Norwegian residents aged 18-65 during the study period. Incident cases were defined as having no previous registration with the same mental disorder in KUHR (from 2006) or NPR (from 2008). We used linear prediction models and mean models to compare incidence rates and test trends before and during the pandemic.Results:During the pandemic, the incidence rates among women were higher or as predicted for OCD in specialist care and for eating disorders in both primary and specialist care. Incidence rates for depression and phobia/OCD among both genders in primary care and phobic anxiety disorders among both genders in specialist care were lower or as predicted.Conclusion:The COVID-19 pandemic may have led to more women needing treatment for OCD and eating disorders in the Norwegian population. The decreased incidence rates for some disorders might indicate that some individuals either avoided seeking help or had improved mental health during the pandemic.