bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of efficacy of different botulinum toxin A concentrations in the treatment of androgenetic alopecia assessed by dermoscopy
Authors: Seoudy Wael Mohamed , Metwally Omnia Ahmed , Elfangary Mona Mohamed , Mohamed Tamer Mohsen 
Published: September 2023

AbstractBackgroundAndrogenetic alopecia (AGA) is the most common type of progressive hair loss in men and women. AGA is characterized by the miniaturization of the hair follicle, leading to the transformation of terminal hair to vellus hair.ObjectiveTo evaluate the efficacy and safety of injecting two different concentrations of botulinum toxin A (BTA) for the treatment of AGA in Egyptian patients.MethodsAdult male (Hamilton–Norwood I–VII) and female (Ludwig I–III) patients (N = 32) were assigned to receive two different concentrations BTA (33.3 and 25 U/mL) on each side of the scalp; in total, there were 15 injections administered on each side, with injection volume of 0.1 mL containing 3.3 U for the right half and 2.5 U for the left half. Treatment efficiency was assessed at baseline, Month 3 and Month 6, by degree of clinical improvement and dermoscopy assessment.ResultsBy Month 6, proportion of male patients (N = 5) classified as Hamilton–Norwood Grade II increased from 0% to 60% (3/5), proportion of female patients (N = 27) classified as Ludwig Grade I also increased from 14.8% (4/27) to 70% (19/27). Dermoscopy result showed a significant increase in vellus hair density from baseline to Month 6 on the right side (33.3 U/mL), while no change was observed on the left (25 U/mL); however, vellus hair density was higher at Month 3 compared to Month 6. There were changes in yellow spots and peripilar sign more on the right side. Adverse reactions reported include irritation, headache, injections site pain, and nausea.ConclusionThe results of the present study showed that BTA is a safe and effective treatment for AGA in both genders. These findings offer a cutting‐edge conceptual structure and therapeutic strategy for the management of AGA in Egyptian population.
Phonology of proper names
Authors: Tanaka Yu 
Published: August 2023

AbstractLinguistic research on proper names has mostly focused on their semantic and syntactic aspects, with relatively little attention being paid to their phonology. This article provides an exploratory overview of issues surrounding the sound patterns of proper names. Some studies argue that names in general tend to resist alternations due to name‐specific faithfulness, and that complex names can behave like simplex words due to a lack of compositionality, while others point to data that may challenge those views. There is also a body of work that examines the sounds of names in the context of cognitive psychology. By reviewing the relevant literature, this article aims to pave the way for further research in name phonology.
ETV5 facilitates tumor progression in head‐neck squamous cell carcinoma
Authors: Yu Shijin , Ma Zongjun , Chen Tao , Wang Hong , Yao Qin , Li Jin , Cheng Jie 
Published: August 2023

AbstractObjectiveE26 transformation‐specific (ETS) factors have emerged as key mediators underlying human tumorigenesis. Here, we sought to characterize the expression pattern, biological roles, and clinical significance of ETS Variant Transcription Factor 5 (ETV5) in head neck squamous cell carcinoma (HNSCC).Subjects and MethodsETV5 expression pattern in HNSCC was determined by bioinformatics interrogations and immunohistochemical staining in primary samples. The associations between its abundance with clinicopathological parameters, and patient survival were evaluated. Colony formation, CCK‐8, flow cytometry, wound healing, and Transwell invasion assays, as well as xenograft models, were utilized to determine the phenotypic changes after ETV5 silencing in vitro and vivo. The potential binding of ETV5 in the Slug promoter was determined by ChIP‐qPCR.ResultsETV5 was significantly overexpressed in HNSCC samples. Its overexpression is significantly associated with aggressiveness features and reduced survival. ETV5 knockdown significantly inhibited cell proliferation, migration, invasion, and induced apoptosis in vitro, and impaired tumor growth in vivo. Moreover, ETV5‐activated Slug transcription by binding its promoter region in HNSCC cells. Patients with ETV5highSlughigh had the worst survival across multiple HNSCC cohorts.ConclusionsOur findings reveal that ETV5 serves as a novel prognostic biomarker and putative oncogene for HNSCC progression likely by activating Slug transcription.
Correlation between the Coaptation and Regeneration of Tendon Stumps in Endoscopic Assisted Achilles Tendon Rupture Repair
Authors: Wu Helin , Dong Jingxian , Dong Dandan , Wei Shijun , Zheng Boyu , Kong Changwang , Xu Feng , Hou Wenguang 
Published: August 2023

ObjectiveWhen the endoscopic Achilles tendon repair technique is utilized, direct stitching of the ruptured site is challenging due to the frayed tendon stumps. To explore whether undesirable coaptation of the tendon stumps influences the generation of the tendons.MethodsThis study is a retrospective analysis of 46 patients who underwent a modified endoscopic Achilles tendon rupture repair from October 2018 to June 2020. Patients were divided into two groups according to the coaptation of tendon stumps on postoperative ultrasonography. Group 1 included 17 cases with undesirable coaptation (<50%), and Group 2 included 29 cases with appropriate coaptation (≥50%). Magnetic resonance imaging (MRI) was obtained postoperatively at 3, 6, and 12 months to evaluate the tendon morphological construction. Clinical evaluations were performed using the American Orthopedic Foot and Ankle Society (AOFAS) ankle‐hind foot score, the Achilles Tendon Total Rupture Score (ATRS), muscle power, and the Achilles tendon resting angle at the final follow‐up. Complications were also encountered. The Student's t‐test and the Mann–Whitney U‐test were used to assess differences among both groups.ResultsThe mean follow‐up time was 37.5 ± 10.6 months in Group 1 and 39.0 ± 11.6 months in Group 2, respectively. The average age in Group 1 is slightly older than in Group 2 (37.3 ± 6.1 vs. 32.7 ± 6.3, p = 0.021). The tendon cross‐section areas and thickness increased initially and decreased later on postoperative MRI evaluation. It also showed a significantly higher signal/noise quotient (SNQ) in Group 1 at postoperative 3 months. At postoperative 6 and 12 months, the SNQ between both groups was similar. The AOFAS score (95.9 ± 5.1 vs. 96.2 ± 4.9, p = 0.832), ATRS score (97.0 ± 3.6 vs. 97.7 ± 3.3, p = 0.527), and muscle power (21.38 vs. 24.74, p = 0.287) were not significantly different between both groups. However, the resting angle of Group 1 was significantly larger than that of Group 2 (4.6 ± 2.4 vs. 2.4 ± 2.3, p = 0.004). There was no difference in the complications (p = 0.628).ConclusionAlthough complete regeneration can be finally achieved, the early stage of tendon stump regeneration can be prolonged due to undesirable coaptation when endoscopic Achilles tendon repair technique is applied. The prolonged high signal duration on MRI indicates the less‐than‐ideal regeneration of the tendon, which might lead to elongation of the tendon.
Self‐efficacy, prosocial impact, and self‐legitimacy as psychological predictors of judicial officer performance
Authors: Hamm Joseph A. , Ropp John W. , Witwer Amanda , Scott Brent A. 
Published: September 2023

AbstractThe current work explores three potential facilitators of judicial performance. Participants in a state‐wide survey of judicial officers (response rate = 33.9 percent) completed self‐report measures of self‐efficacy, prosocial impact, and self‐legitimacy as well as subjectively perceived performance. Objective performance data collected by the state court administrative office were then merged with the survey data. Latent variable analysis confirmed the three predictor constructs' separability, and although all four concepts were correlated, self‐efficacy was the sole independent predictor of subjective performance. An unplanned mediation analysis suggested significant indirect effects of self‐legitimacy and prosocial impact on subjectively assessed performance through self‐efficacy. Regarding objective performance, self‐efficacy emerged as the only significant correlate or predictor. The research therefore empirically demonstrates the empirical distinctiveness of self‐efficacy, prosocial impact, and self‐legitimacy and provides some exploratory support for a causal model whereby self‐efficacy provides the proximal impact on performance but is itself facilitated by prosocial impact and self‐legitimacy.
Dyspnoea relief as an inherent benefit of high flow nasal cannula therapy: A laboratory randomized trial in healthy humans
Authors: Bianquis Clara , Rolland‐Debord Camille , Rivals Isabelle , Similowski Thomas , Morélot‐Panzini Capucine 
Published: September 2023

AbstractBackground and ObjectivePersistent dyspnoea is a public health issue for which the therapeutic arsenal is limited. This study tested high‐flow nasal cannula therapy (HFNT) as a means to alleviate experimental dyspnoea.MethodsThirty‐two healthy subjects underwent an experimental dyspnoea induced by thoracoabdominal elastic loading. HFNT was administered with alternately FiO2 of 100% (HFNT100) or 21% (HFNT21). The sensory (S‐VAS) and affective (A‐VAS) components of dyspnoea, transcutaneous CO2 pressure (PtcCO2), pulse‐oximetry oxygen saturation (SpO2), heart rate, respiratory rate and skin galvanometry were monitored continuously. Three experimental sessions of 8 min were conducted: the first session consisted in familiarization with the experimental dyspnoea and the next two sessions tested the effects of HFNT100 and HFNT21 alternatively in a randomized order.ResultsHFNT21 and HFNT100 significantly reduced dyspnoea, respectively of ∆A‐VAS = 0.80 cm [−0.02–1.5]; p = 0.007 and ∆A‐VAS = 1.00 cm [0.08–1.75]; p < 0.0001; ∆S‐VAS = 0.70 cm [−0.15–1.98]), p < 0.0001 and ∆S‐VAS = 0.70 cm [0.08–1.95]), p = 0.0002) with no significant difference between HFNT21 and HFNT100. HFNT did not significantly alter the respiratory rate or the heart rate, reduced PtcCO2 only on room air and GSR under both experimental conditions.ConclusionHFNT was associated with a statistically significant reduction in the intensity of the sensory and affective components of dyspnoea, independent of oxygen addition. This relief of laboratory dyspnoea could result from a reduction of afferent‐reafferent mismatch.
Making “fast friends” online in middle childhood and early adolescence
Authors: Swerbenski Katherine L. , Barnett Kierin C. , Devine Patricia G. , Shutts Kristin 
Published: September 2023

AbstractClose peer relationships are critical to children's and adolescents’ healthy development and well‐being, yet youth sometimes struggle to make friends. The present work tested whether an online version of the Fast Friends procedure could engender closeness among 9‐ to 13‐year‐old youth. Participant dyads (N = 131), matched in age and gender, were randomly assigned to answer personal questions that encourage self‐disclosure and play a collaborative game (Fast Friends condition) or to engage in similar activities without self‐disclosure or collaboration (control condition). Fast Friends dyads reported feeling closer and expressed more interest in future contact than control dyads. The discussion addresses potential future uses and implications of an online Fast Friends procedure.
Co‐chaperone BAG3 enters autophagic pathway via its interaction with microtubule associated protein 1 light chain 3 beta
Authors: Körschgen Hagen , Baeken Marius , Schmitt Daniel , Nagel Heike , Behl Christian 
Published: September 2023

AbstractThe co‐chaperone BAG3 is a hub for a variety of cellular pathways via its multiple domains and its interaction with chaperones of the HSP70 family or small HSPs. During aging and under cellular stress conditions in particular, BAG3, together with molecular chaperones, ensures the sequestration of aggregated or aggregation‐prone ubiquitinated proteins to the autophagic‐lysosomal system via ubiquitin receptors. Accumulating evidence for BAG3‐mediated selective autophagy independent of cargo ubiquitination led to analyses predicting a direct interaction of BAG3 with LC3 proteins. Phylogenetically, BAG3 comprises several highly conserved potential LIRs, LC3‐interacting regions, which might allow for the direct targeting of BAG3 including its cargo to autophagosomes and drive their autophagic degradation. Based on pull‐down experiments, peptide arrays and proximity ligation assays, our results provide evidence of an interaction of BAG3 with LC3B. In addition, we could demonstrate that disabling all predicted LIRs abolished the inducibility of a colocalization of BAG3 with LC3B‐positive structures and resulted in a substantial decrease of BAG3 levels within purified native autophagic vesicles compared with wild‐type BAG3. These results suggest an autophagic targeting of BAG3 via interaction with LC3B. Therefore, we conclude that, in addition to being a key co‐chaperone to HSP70, BAG3 may also act as a cargo receptor for client proteins, which would significantly extend the role of BAG3 in selective macroautophagy and protein quality control.
Endoscope‐assisted three‐wire technique for extensive nasal septum resection in horses
Authors: Ratliff Bridget L. , Bauck Anje G. , Roe Heather A. , Freeman David E. 
Published: August 2023

AbstractObjectiveTo describe a 3‐wire method with endoscopic guidance for extensive nasal septum resection.Study designRetrospective study.Sample populationThirteen horses with nasal septum diseases.MethodsIn anesthetized horses in left lateral recumbency, endoscopic guidance was used to place obstetrical wires for the ventral and caudal incisions in the nasal septum and a trephine opening was used to place the dorsal wire. The rostral aspect of the septum was incised with a scalpel, followed by incisions with the preplaced wires, and the nasal passages were packed with gauze. Horses were recovered with a temporary tracheotomy.ResultsConversion to intraoral placement of wires was required in two horses, one to correct entangled wires and the other because hemorrhage obscured the endoscopic view. Exercise tolerance was improved postoperatively, abnormal respiratory noise was decreased or eliminated by surgery in all horses, and all owners were satisfied. One Thoroughbred racehorse performed with modest success.ConclusionsModification of the 3‐wire method was effective and safe for extensive nasal septum removal. Technical complications of the procedure include entangling of wires and intraoperative hemorrhage.Clinical significanceEndoscopic guidance can be used to place obstetrical wires for nasal septum resection in small horses and precludes use of a large tracheotomy for anesthetic delivery. Reasons for athletic failures were difficult to establish retrospectively, although assessment of postoperative noise at speed might be more relevant to recovery of athletic potential than assessment at slower gaits.
The atypical ‘hippocampal’ glutamate receptor coupled to phospholipase D that controls stretch‐sensitivity in primary mechanosensory nerve endings is homomeric purely metabotropic GluK2
Authors: Thompson Karen J. , Watson Sonia , Zanato Chiara , Dall'Angelo Sergio , De Nooij Joriene C. , Pace‐Bonello Bethany , Shenton Fiona C. , Sanger Helen E. , Heinz Beverly A. , Broad Lisa M. , Grosjean Noelle , McQuillian Jessica R. , Dubini Marina , Pyner Susan , Greig Iain , Zanda Matteo , Bleakman David , Banks Robert W. , Bewick Guy S. 
Published: September 2023

AbstractA metabotropic glutamate receptor coupled to phospholipase D (PLD‐mGluR) was discovered in the hippocampus over three decades ago. Its pharmacology and direct linkage to PLD activation are well established and indicate it is a highly atypical glutamate receptor. A receptor with the same pharmacology is present in spindle primary sensory terminals where its blockade can totally abolish, and its activation can double, the normal stretch‐evoked firing. We report here the first identification of this PLD‐mGluR protein, by capitalizing on its expression in primary mechanosensory terminals, developing an enriched source, pharmacological profiling to identify an optimal ligand, and then functionalizing it as a molecular tool. Evidence from immunofluorescence, western and far‐western blotting indicates PLD‐mGluR is homomeric GluK2, since GluK2 is the only glutamate receptor protein/receptor subunit present in spindle mechanosensory terminals. Its expression was also found in the lanceolate palisade ending of hair follicle, also known to contain the PLD‐mGluR. Finally, in a mouse model with ionotropic function ablated in the GluK2 subunit, spindle glutamatergic responses were still present, confirming it acts purely metabotropically. We conclude the PLD‐mGluR is a homomeric GluK2 kainate receptor signalling purely metabotropically and it is common to other, perhaps all, primary mechanosensory endings.
Epidemiological characteristics of multidrug-resistant
Acinetobacter baumannii
ST369 in Anhui, China
Authors: Huang Yi , Ali Md Roushan , Li Wei , Wang Wanying , Dai Yuanyuan , Lu Huaiwei , He Zhien , Li Yujie , Sun Baolin 
Published: September 2023

ABSTRACT

Acinetobacter baumannii
is of growing concern for global health owing to its ability to evade the immune system and develop resistance to antibiotics. We analyzed
A. baumannii
using the National Center for Biotechnology Information (
https://www.ncbi.nlm.nih.gov/pathogens
) database and observed that the ST369 strain isolated in China constituted over 50% of the globally prevalent ST369 clones. This finding highlights the significant impact of ST369 on public health in China. In this study, we examined eight strains of multidrug-resistant
A. baumannii
ST369 isolated from a provincial hospital in China. We conducted whole-genome sequencing, comparative genomic analysis, and phenotypic experiments, and used the
Galleria mellonella
infection model to achieve a comprehensive understanding of the organism. In our study, we identified two mutations, G540A and G667D, on the
wzc
gene of
A. baumannii
ST369 that can potentially affect bacterial virulence and viscosity. We also verified the impact of these mutations on virulence and resistance. In addition, we examined two proteins, AB46_0125 and AB152_03903, which may play a role in virulence. These findings establish a foundation for future studies on clinical ST369 isolates harboring such mutations.

IMPORTANCE

Acinetobacter baumannii
is a major health threat due to its antibiotic resistance and ability to cause nosocomial infections. Epidemiological studies indicated that the majority of globally prevalent ST369 clones originated from China, indicating a significant impact on public health in the country. In this study, we conducted whole-genome sequencing, comparative genomics, and
Galleria mellonella
infection model on eight
A. baumannii
ST369 isolates collected from a provincial hospital in China to comprehensively understand the organism. We identified two mutations (G540A and G667D) on the
wzc
gene that can affect bacterial virulence and viscosity. We confirmed their impact on resistance and virulence. We also investigated the potential involvement of AB46_0125 and AB152_03903 proteins in virulence. This finding provides a theoretical reference for further research on
A. baumannii
ST369 clinical isolates with similar mutations.
The efficacy of prevention for colon cancer based on the microbiota therapy and the antitumor mechanisms with intervention of dietary
Lactobacillus
Authors: Xu Fuqiang , Li Qiaoqiao , Wang Shuyang , Dong Miaoyin , Xiao Guoqing , Bai Jin , Wang Junkai , Sun Xisi 
Published: September 2023

ABSTRACT

Gut microbiota and their secreted metabolites have an influence on the initiation and progression of colon cancer. Probiotics are extensively perceived as a potential microbiota-modulation strategy to promote the health of the host, while the effectiveness of preventing colon cancer based on microbiota therapy has not been confirmed, and antitumor mechanisms influenced by microbiota and their metabolites with the intervention of probiotics remain to be further investigated.
In vitro
,
Lactobacillus
(JY300-8 and JMR-01) significantly inhibited the proliferation of CT26, HT29, and HCT116 cells. Moreover, we studied the prevention and therapy efficiency of
Lactobacillus
and its underlying antitumor mechanism through the alteration of gut microbiota and their metabolites regulated by
Lactobacillus
in colon cancer models in mice. We demonstrated that the pre-administration of
Lactobacillus
(JY300-8 and JMR-01) for 20 days before establishing tumor models resulted in an 86.21% reduction in tumor formation rate compared to tumor control group. Subsequently, continuous oral administration of living
Lactobacillus
significantly suppresses tumor growth, and tumor volumes decrease by 65.2%. Microbiome and metabolome analyses reveal that
Lactobacillus
suppresses colonic tumorigenesis and progression through the modulation of gut microbiota homeostasis and metabolites, including the down-regulation of secondary bile acids, sphingosine 1-phosphate (S1P), and pyrimidine metabolism, as well as the production of anticarcinogenic compounds in tumor-bearing mice. Additionally, metabolome analyses of
Lactobacillus
(JY300-8 and JMR-01) indicate that living
Lactobacillus
could reduce the relative abundance of alanine and L-serine to suppress tumor progression by regulating the tumor microenvironment, including down-regulation of pyrimidine metabolism and S1P signaling in cancer. These findings provide a potential prevention strategy and therapeutic target for colon cancer through the intervention of dietary
Lactobacillus
.

IMPORTANCE
The modulation of gut microbiota and metabolites has a significant influence on the progression of colon cancer. Our research indicated that the intervention of probiotics is a potentially feasible strategy for preventing colon cancer. We have also revealed the underlying antitumor mechanism through the alteration of gut microbiota and their metabolites, which could lead to broader biomedical impacts on the prevention and therapy of colon cancer with microbiota-based therapy regulated by probiotics.