bluuebunny/crossref_metadata_2025_split huggingface dataset:
Single cell immunoprofile of synovial fluid in rheumatoid arthritis with TNF-α/JAK inhibitor treatment
Authors: Xu Heng , Xia Xuyang , He Chenjia , Xue Zhinan , Wang Yuelan , Ren Zhixiang , Huang Yupeng , Luo Han , Chen Hai-Ning , Zhang Weihan , Huang Li-Bin , Shi Yunying , Bai Yangjuan , Cai Pei , Wang Lanlan , Zhang Feng , Qian Maoxiang , Zhang Wei , Shu Yang , Yin Geng , Xie Qibing 
Published: July 2023

Abstract
Increased volume of synovial fluid (SF) with large amounts of immune cells is present in the joint cavity of many patients with rheumatoid arthritis (RA), syndrome of which can be controlled by TNF-α/JAK inhibitors. Here, we applied single-cell RNA sequencing (scRNA-seq) and subsequent validations to profile the cell components, and their crosstalk in SF from RA patients pre-/post-treated with adalimumab/tofacitinib. Although the proportion of pathogenic cells (e.g., SPP1+ macrophage and CXCL13+CD4+ T cell) were not decreased after treatment, several genes (e.g., SPP1 and STAT1), molecular pathways (e.g., JAK/STAT) and cell-cell communications were altered in drug-specific manner. Particularly, SPP1+ macrophage can increase the inflammatory response of fibroblast-like synoviocytes in vitro and exhibit the most prolific communications with CXCL13+CD4+ T cell, which are abolished after treatment and positively related to treatment efficacy. Our study establishes the correlation of the pathogenic SF cells with progression and treatment outcomes in RA.
Impacts of Pharmacists-Managed Outpatient Clinic in patients with Hepatitis C virus infection: A Retrospective Study in China
Authors: Huang Can , Gao Aiping , Guo Cuixia , Jia Jinmei , Zheng Yonghong , liu wei 
Published: July 2023

Abstract
Objective
Pharmacists are health care professionals who are actively involved in identifying and solving drug-related problems (DRPs) in patients with hepatitis C virus (HCV) infection. However, the effectiveness of pharmaceutical services at outpatient clinic for patients with HCV infection have not been reported in China. This study aims to describe and investigate the impacts of pharmacists-managed outpatient clinic in patients with HCV infection.
Methods
We conducted a descriptive and retrospective study between May 2020 and April 2022. In order to give full play to the efficacy of direct-acting antivirals (DAAs), we established a referral process for HCV patients with DAAs. Doctors prescribed DAAs for HCV-infected outpatients, and then transferred them to the outpatient clinic managed by pharmacists. Pharmacists cooperated to complete the pharmaceutical monitoring of DAAs treatment for patients. The pharmacist conducted a comprehensive evaluation of the patient's medication and developed planned intervention measures based on identified DRPs.
Results
A total of 473 eligible patients participated in 851 pharmaceutical care. A total of 518 DRPs were identified (an average of 1.1 per patient). Treatment effectiveness (48.8%) was the most common DRP. The most commonly recommended intervention was changing the drug (18.3%). There were 97.1% patients accepting the interventions and 93.05% patients completely implemented. The overall sustained virologic response at week 12 posttreatment (SVR12) rate was 98.5% (466/473). The most cost-effective treatment was selected in 98.7% of patients.
Conclusions
We confirmed that pharmacists had a valuable role to perform pharmacy services for HCV-infected outpatients. The intervention of pharmacists is effective in solving the DRPs and saving drug costs.
Influence of various hosts on the life cycle, morphometrics, feeding and ovipositional preference for invasive fall armyworm, Spodoptera frugiperda (J.E. Smith)
Authors: K Jatin , SPS Tomar , Kukanur Vinod , Kota Sathish , N Ramana , Mishra Suraj , Jaba Jagdish 
Published: July 2023

Abstract
Influence of diverse natural hosts (major cereals, legumes, Bt cotton, oil seed crops and artificial diet) on the biology, morphometrics, and ovipositional preference of invasive fall armyworm were investigated under laboratory conditions. The results revealed that FAW could complete its life cycle on all the host crops except Bt-cotton. Among the various hosts, Maize was the best suitable host for FAW. It supported FAW for faster development, most robust larvae and pupae, and adults. Among the hosts studied Cotton and Cowpea were least preferred and had adverse effects on FAW growth and development. The order of host preference from most preferred to least preferred host being maize followed sorghum, castor, artificial diet, sunflower, soybean, rice, pearl millet, cotton and cowpea. Our findings can help to redefine the protocols for quicker multiplication of FAW, implement newer Integrated pest management (IPM) programs, develop new forecasting models and to develop new cultural management practices.
Heterogeneous Warming Rates and Decline in Snow Persistence across Mountains Worldwide
Authors: Ha Kyung-Ja , Blau Manuel Tobias , Kad Pratik , Turton Jenny V. 
Published: July 2023

Abstract
The warming of mountainous regions has become evident in recent years with a global average warming rate of 1.41 °C from 1979 to 2022. Our study aims to understand observed changes in snow persistence across mountain regions worldwide, using reanalysis and satellite data. By taking a global perspective, we bridge the gap between regional findings and provide a comprehensive understanding of the impact of increases in global warming on mountain snow decline. Here, we demonstrate that the mountain snow persistence is significantly declining over the past 44 years, with a global mean decline of 7.67 %. The trends in regional snow cover persistence exhibit a heterogeneous and non-linear response to its regional warming rate. A decomposition of snow depth reveals the snowfall ratio majorly contributes to high latitudes, and the snowfall accumulation ratio plays a large role where the melting trend exceeds the snowfall trend. The recent Coupled Model Intercomparison Project 6 (CMIP6) has shown limitations in accurately capturing the mountain snow persistence. Our study provides valuable insights into the intricate interplay between global warming and declining snow cover persistence. Our findings attribute the observed reduction in snow persistence and shed light on decreased snowfall with increased snow melting contributions. Disclosure of the impact of this changing mountain snow is critical for informing sustainable development and preparing for the potential consequences of these changes.
CuCrZr alloy manufactured by LPBF process: correlation between microstructure, mechanical and thermal properties
Authors: Biffi Carlo Alberto , Fiocchi Jacopo , Boldrini Stefano , Tuissi Ausonio 
Published: July 2023

Abstract
Copper based alloys are promising materials for electrical and thermal devices. In this respect, the use of laser powder bed fusion (LPBF) allows the realization of 3D complex structures, possibly enhancing the functional performances of such devices. LPBF also induces refined microstructures and build-up of residual stresses, due to the rapid solidifications and high cooling rate. In this work a CuCrZr alloy was manufactured by LPBF and a process feasibility window was defined. The effect of a heat treatment, consisting of solution annealing and artificial aging, and of the building direction on the microstructure, tensile, and thermal properties was evaluated. It was found that thermal conductivity is improved by the heat treatment and that thermal conductivity resulted anisotropic, being higher in the growth direction.
Molecular mechanisms in metal oxide nanoparticle Tryptophan interactions
Authors: Kessler Vadim , Nefedova Alexandra , Svensson Fredric , Vanetsev Alexander , Agback Peter , Agback Tatiana , Kloo Lars , Tätte Tanel , Ivask Angela , Seisenbaeva Gulaim 
Published: July 2023

Abstract
One of the crucial metabolic processes for both plant and animal kingdoms is oxidation of amino acid tryptophan (TRP) that regulates the plant growth and controls hunger and sleeping patterns in animals. Here, we report revolutionary insights into how this process can be crucially effected by interactions with metal oxide nanoparticles (NP), creating a toolbox for a plethora of important biomedical and agricultural applications. Molecular mechanisms in TRP-NP interactions were revealed by NMR and optical spectroscopy for ceria and titania, and by X-ray single crystal and a computational study of a model TRP-polyoxometalate complexes. Nanozyme activity, involving concerted proton and electron transfer to the NP surface for oxides with high oxidative potential, CeO2 or WO3, converted TRP into a tricyclic organic acid resembling natural plant hormones, auxins. TiO2, a much poorer oxidant, was strongly binding TRP without concurrent oxidation in the dark, but oxidized it non-specifically via release of reactive oxygen species (ROS) in daylight.
The Potential Role of Ocular and Otolaryngological Mucus Proteins in Myalgic Encephalomyelitis/ Chronic Fatigue Syndrome
Authors: Huitsing Kaylin , Tritsch Tara , Arias Francisco J. Carrera , Collado Fanny , Aenlle Kristina , Nathason Lubov , Fletcher Mary Ann , Klimas Nancy G. , Craddock Travis 
Published: July 2023

Abstract
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating illness associated with a constellation of other symptoms. While the most common symptom is unrelenting fatigue, many individuals also report suffering from rhinitis, dry eyes and a sore throat. Mucin proteins are responsible for contributing to the formation of mucosal membranes throughout the body. These mucosal pathways contribute to the body’s defense mechanisms involving pathogenic onset. When compromised by pathogens the epithelium releases numerous cytokines and enters a prolonged state of inflammation to eradicate any particular infection. Based on genetic analysis, and computational theory and modeling we hypothesize that mucin protein dysfunction may contribute to ME/CFS symptoms due to the inability to form adequate mucosal layers throughout the body, especially in the ocular and otolaryngological pathways leading to low grade chronic inflammation and the exacerbation of symptoms.
Mechanical and Acoustic Properties of Sandstone under Freeze-Thaw and Cyclic Loading Alternations
Authors: Yuan Yeqing 
Published: July 2023

Abstract
This research investigates the mechanical and acoustic properties of sandstone under alternating freeze-thaw and cyclic loading (FTF) using acoustic emission (AE) and ultrasonic testing techniques. The sandstone specimens are subjected to five cycles of freeze-thaw followed by ten cycles of low stress loading-unloading (stress lower than 40% of the rock's ultimate strength), referred to as the first stage of alternating action (Stage 1). This process is repeated several times until the failure of the rock sample, simulating the alternating effects of multiple freeze-thaw cycles and cyclic loading that may occur in cold region engineering. The research findings are as follows: With the progress of freeze-thaw cycles and alternating action of cyclic loading, the secant modulus and wave velocity of the rock generally show a decreasing trend. The first stress loading-unloading in each stage significantly enhances the secant modulus and longitudinal wave velocity of the freeze-thawed rock. The residual strain generated by the first loading-unloading is significantly higher than that of subsequent loading-unloading. Prior to rock failure, both the secant modulus and wave velocity experience significant decreases. These two phenomena serve as indicators for determining the critical failure of the rock, allowing the classification of rock states into safe, critical, and failure states. Freeze-thawed sandstone exhibits two significant acoustic emission characteristics during the cyclic loading phase: an initial loading phase is accompanied by a surge in the number of acoustic emission events, while after the first loading-unloading, the number of acoustic emission events stabilizes, forming a wave-like pattern of change. Additionally, an AE index is proposed to evaluate the degree of damage to the rock after each freeze-thaw stage, and its effectiveness is verified. The AE index reflects a gradual increase in freeze-thaw damage, followed by a sudden intensification, leading to failure and exhibiting three stages of evolution. An AE index of 2.2 is defined as an early warning indicator, while an AE index of 2.95 is defined as the failure indicator for the rock. Finally, based on experimental data, a damage evolution model is proposed, which describes the entire process of sandstone damage and effectively reflects the three-stage characteristics of rock freeze-thaw damage evolution.
Higher Bernstein Polynomials and Multiple Poles
Authors: BARLET Daniel 
Published: July 2023

Abstract
The goal of this paper is to give a converse to the main result of my previous paper [12], so to prove the existence of a pole with an hypothesis on the Bernstein polynomial of the (a,b)-module generated by the germ ω ∈ Ωn+1. A 0 difficulty to prove such a result comes from the use of the formal completion in f of the Brieskorn module of the holomorphic germ f : (Cn+1, 0) → (C, 0) which does not give access to the cohomology of the Milnor’s fiber of f, which by definition, is outside {f = 0}. This leads to introduce convergent (a,b)-modules which allow this passage. In order to take in account Jordan blocs of the monodromy in our result we introduce the semi-simple filtration of a (convergent) geometric (a,b)-module and define the higher order Bernstein polynomials in this context which corresponds to a decomposition of the ”standard” Bernstein polynomial in the case of frescos. Our main result is to show that the existence of a root in −α − N for the p-th Bernstein polynomial of the fresco generated by a holomorphic form ω ∈ Ωn+1 in 0 the (convergent) Brieskorn (a,b)-module Hn+1 associated to f, under the hypothesis 0 that f has an isolated singularity at the origin relative to the eigenvalue exp(2iπα) of the monodromy, produces poles of order at least p for the meromorphic extension of the (conjugate) analytic functional, for some h ∈ Z: 1􏰌 ̄ω′ ∈ Ωn+1 􏰐→ |f|2λf−hρω ∧ ω ̄′ 0 Γ(λ) Cn+1 at points −α − N for N and h well chosen integers. This result is new, even for p = 1. As a corollary, this implies that in this situation the existence of a root in −α − N for the p-th Bernstein polynomial of the fresco generated by a holomorphic ∗Barlet Daniel, Institut Elie Cartan UMR 7502Universit ́e de Lorraine, CNRS, INRIA et Institut Universitaire de France, BP 239 - F - 54506 Vandoeuvre-l`es-Nancy Cedex.France.e-mail : daniel.barlet@univ-lorraine.fr 1 form ω ∈ Ωn+1 implies the existence of at least p roots (counting multiplicities) for 0 the usual reduced Bernstein polynomial of the germ (f, 0).In the case of an isolated singularity we obtain that for each α ∈]0, 1] ∩ Q the biggest root −α − m of the reduced Bernstein polynomial of f in −α − N produces a pole at −α − m for some h ∈ Z for the meromorphic extension of the distribution 1 ̄□ −→ Γ(λ)|f|2λf−h□.
AMS classification. 32 S 25; 32 S 40 ; 34 E 05
Prediction of the Polyacrylamide Adsorption onto Calcite Surface
Authors: Silvino Pedro Felipe Gadelha , Souza Carlos Henrique Linhares , Nascimento Maria Thereza Saldanha Fontenele Sousa , Oliveira José Carlos Alexandre , Lucena Sebastião Mardônio Pereira 
Published: July 2023

Abstract

Polymer flooding in petroleum reservoirs is one of the main techniques used for enhanced oil recovery. However, the retention of polymers on the surface of rock pores by adsorption has been one of the major problems that affect the efficiency of the process and cause a reduction in the formation permeability, especially in carbonate reservoirs. A more detailed analysis of the mechanisms involved in the adsorption of the polymer on the rock surface can be performed through molecular simulation. The present study used a combination of molecular dynamics and Monte Carlo techniques to evaluate the adsorption of polyacrylamide on calcite. Two models of polyacrylamide molecules were constructed, with 30 and 50 monomers. The behavior of these molecules in the aqueous phase was determined through molecular dynamics simulations, obtaining stable conformations of the polymer in water. With the stabilized polyacrylamide structures obtained, we performed Monte Carlo simulations to study the adsorption of polyacrylamide on calcite surface. Values of maximum adsorbed amount and molecular conformations with different polymeric chain sizes and at different concentrations showed good agreement with experimental results obtained from the literature.
Estimation of Surface Runoff Using SCS-CN Remote Sensing and GIS in Sanjab Watershed
Authors: Mujeeb Mujeebullah 
Published: July 2023

Abstract
Accurate estimation of surface runoff is not only an important task for planning and designing hydro technical structures but also important for proper watershed management. The Watershed is a perfect unit for planning and managing land and water resources. The catchment's direct runoff is influenced by rainfall, land cover, and type of soil. The most widely used technique for calculating runoff from rainfall is the curve number method (SCS-CN). The curve number is based on the properties of the soil and land usage. This study was carried out in the Sanjab watershed, located in the Enjeal district of Herat province, Afghanistan, using remote sensing and GIS. The reason for selecting this area is that in 2021 the ministry of Agriculture Irrigation and livestock intended to create about 14,000 hectares of pistachio commercial gardens in the mentioned area, but they didn’t find a reasonable source for its irrigation the only source available here were Sanjab River and its surface runoff to be stored and used, So I decided to study the existence watershed and this will help in existence flood water management and it’s effective usage for pistachio garden, The total area of watershed 181km2 or 18080 hectares. Soil maps, land use maps, and slope maps were generated in GIS10.4 Environment. The Soil Conservation Service- Curve Number (SCS-CN) method is used here as a lumped model; in this research, ten-year (2012–2021) rainfall data was used to obtain the amount of surface runoff in Sanjab watershed at the result the highest volume of surface runoff was in 2019 about 17,298,885 cubic meters and the lowest was in 2014 about 9,061,754 cubic meters and the average amount was obtained 12,702,138 cubic meters per year.
Effects of Different Grades of Drought on Vegetation in Ecologically Fragile Karst Areas of Guangxi
Authors: Yanli Chen , Ying Xie , Mingzhi Li , Min Xie , Weihua Mo 
Published: July 2023

Abstract
Drought is a major threat to rocky desertification control and ecological restoration in ecologically fragile karst areas of Guangxi Province. In this study, the normalized difference vegetation index (NDVI), fractional vegetation cover (FVC) and net primary productivity (NPP) were selected as vegetation remote sensing parameters, and the spatial response characteristics of different types of vegetation in karst areas of Guangxi Province to light, moderate, severe and extreme drought were analyzed to provide scientific basis for the evaluation of the impact of drought on vegetation in karst areas. The results are as follows: (1) NDVI, FVC and NPP showed a fluctuating increasing trend from 2000 to 2022, and the increasing rates were 0.058, 6.90%, and 43.3gC.m-2 per decade respectively. During this period, the number of light, moderate and severe drought days showed a decreasing trend, but the number of extreme drought days tended to increase. (2) The negative correlation of NDVI, FVC and NPP and drought increased from moderate to extreme drought, and from light to extreme drought, the negative correlation between NDVI and FVC and drought decreased, while that of NPP increased. (3) Light and moderate drought had obvious negative effects on Chinese fir and broad-leaved forest, while severe and extreme drought had obvious negative effects on eucalyptus and bamboo forest.
SFA-Net: Scatter-Fusion Attention Network for Person Re-identification
Authors: Wang Shanshan , Chen Ying 
Published: July 2023

Abstract
The utilization of attention mechanisms has demonstrated promising outcomes in diverse vision tasks, like the Person re-identification (re-ID) task. In the context of person re-ID, the acquisition of effective convolutional features through attention mechanisms plays a crucial role. However, person re-ID presents a unique challenge as individuals manifest themselves through multiple body regions simultaneously. Consequently, a holistic approach is necessary to encode high-order interactions among local features for accurate recognition. To address these challenges, we propose the Scatter-Fusion Attention Network (SFA-Net) as a viable solution. The scatter operation involves the instantiation of multiple attention blocks, enabling simultaneous attention across multiple body areas and the creation of attention maps for these regions. Subsequently, the Fusion operation redistributes these attentions to multiple locations before merging the feature maps into a comprehensive one. SFA-Net effectively leverages the attention mechanism to scatter and fuse attention blocks, facilitating the flow of information among them. The SFA mechanism incorporates spatial and channel-wise attention mechanisms, allowing for a comprehensive emphasis on foreground objects and effective elimination of background clutter, in contrast to conventional attention learning that considers only current features at a time. Extensive experimental results verified that SFA-Net achives state-of-the-art person re-ID on two datasets(Market-1501 and DukeMTMC-reID).