bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genome-wide association study identifies novel risk loci for apical periodontitis
Authors: Petty L.E. , Silva R. , de Souza L. Chaves , Vieira A.R. , Shaw D.M. , Below J.E. , Letra Ariadne 
Published: January 2023

Abstract
Apical periodontitis (AP) is a common consequence of root canal infection leading to periapical bone resorption. Microbial and host genetic factors, and their interactions, have been shown to play a role in AP development and progression. Variations in a few genes have been reported in association with AP, however, the lack of genome-wide studies has hindered progress in understanding the mechanisms involved in AP. Here, we report the first genome-wide association study of AP in a well-characterized population. Male and female adults (n=932) presenting with deep caries with AP (cases) or without AP (controls) were included. Genotyping was performed using the Illumina Expanded Multi-Ethnic Genotyping Array. Single-variant association testing was performed adjusting for sex and five principal components. Subphenotype association testing, analyses of genetically regulated gene expression, polygenic risk score and phenome-wide association (PheWAS) analyses were also performed. Eight loci reached near-genome-wide significant association with AP (p < 5 x 10-6); gene-focused analyses replicated three previously reported associations (p < 8.9 x 10-5). Sex-specific and subphenotype analyses revealed additional significant associations with variants genome-wide. Functionally oriented gene-based analyses revealed eight genes significantly associated with AP (p < 5 x 10-5), and PheWAS analysis revealed 33 phecodes associated with AP risk score (p < 3.08 x 10-5). This study identified novel genes/loci contributing to AP and revealed specific contributions to AP risk in males and females. Importantly, we identified additional systemic conditions significantly associated with AP risk. Our findings provide strong evidence for host-mediated effects on AP susceptibility.
SERTÃO SENTIDO: O CORRER DA VIDA EM UMA COMUNIDADE BARRANQUEIRA NO NORTE DE MINAS GERAIS
Authors: Narciso Rocha de Paula Andréa Maria , Almeida Crisóstomo Adinei 
Published: January 2023

Este artigo tem o objetivo de etnografar uma comunidade tradicional, na beira nas margens do Rio São Francisco, no sertão do norte de Minas Gerais. Mostrar o cotidiano do viver na roça, o conviver com rio, o estar no lugar e a compreensão dos moradores do seu modo de vida. Através dos depoimentos dos moradores, foi possível compreender os símbolos, os lugares, praticas do saber-fazer que formam e delimitam as normas de uso comum do território e definem a produção e reprodução social e simbólica do modo de vida das pessoas no lugar. Na atribuição da identidade os moradores da comunidade da Barra do Pacuí atribuem valores e sensações no/ao lugar que vivem através da representação da forma de cultivar a terra, na preparação da comida dos moradores, nos momentos do sagrado, no correr da vida.
VÍRUS, POLÍTICA E LINGUAGEM. MEUS APRENDIZADOS EM 10 ANOS VIVENDO COM HIV
Authors: Mello Ramon Nunes 
Published: January 2023

Nesse artigo, apresento os desafios vividos no percurso como poeta e ativista desde que foi aberta publicamente minha sorologia para o HIV, através de um diálogo sobre o vírus/linguagem no campo da poesia e literatura.
Understanding the Subjective Experience of Long-term Remote Measurement Technology Use for Symptom Tracking in People With Depression: Multisite Longitudinal Qualitative Analysis
Authors: White Katie M , Dawe-Lane Erin , Siddi Sara , Lamers Femke , Simblett Sara , Riquelme Alacid Gemma , Ivan Alina , Myin-Germeys Inez , Haro Josep Maria , Oetzmann Carolin , Popat Priya , Rintala Aki , Rubio-Abadal Elena , Wykes Til , Henderson Claire , Hotopf Matthew , Matcham Faith 
Published: January 2023

Background
Remote measurement technologies (RMTs) have the potential to revolutionize major depressive disorder (MDD) disease management by offering the ability to assess, monitor, and predict symptom changes. However, the promise of RMT data depends heavily on sustained user engagement over extended periods. In this paper, we report a longitudinal qualitative study of the subjective experience of people with MDD engaging with RMTs to provide insight into system usability and user experience and to provide the basis for future promotion of RMT use in research and clinical practice.

Objective
We aimed to understand the subjective experience of long-term engagement with RMTs using qualitative data collected in a longitudinal study of RMTs for monitoring MDD. The objectives were to explore the key themes associated with long-term RMT use and to identify recommendations for future system engagement.

Methods
In this multisite, longitudinal qualitative research study, 124 semistructured interviews were conducted with 99 participants across the United Kingdom, Spain, and the Netherlands at 3-month, 12-month, and 24-month time points during a study exploring RMT use (the Remote Assessment of Disease and Relapse-Major Depressive Disorder study). Data were analyzed using thematic analysis, and interviews were audio recorded, transcribed, and coded in the native language, with the resulting quotes translated into English.

Results
There were 5 main themes regarding the subjective experience of long-term RMT use: research-related factors, the utility of RMTs for self-management, technology-related factors, clinical factors, and system amendments and additions.

Conclusions
The subjective experience of long-term RMT use can be considered from 2 main perspectives: experiential factors (how participants construct their experience of engaging with RMTs) and system-related factors (direct engagement with the technologies). A set of recommendations based on these strands are proposed for both future research and the real-world implementation of RMTs into clinical practice. Future exploration of experiential engagement with RMTs will be key to the successful use of RMTs in clinical care.
Real-time Assessment of the Bidirectional Relationship Between Affective States and Glucose: Protocol for a 14-Day Observational Study
Authors: Rethorst Chad D , Githinji Phrashiah , Seguin-Fowler Rebecca A , MacMillan Uribe Alexandra L , Szeszulski Jacob , Liao Yue 
Published: January 2023

Background
Glucose variability increases cardiometabolic disease risk. While many factors can influence glucose levels, postprandial glucose response is the primary driver of glucose variability. Furthermore, affect may directly and indirectly impact glucose variability through its effect on eating behavior. Continuous glucose monitors (CGMs) facilitate the real-time evaluation of blood glucose, and ecological momentary assessment (EMA) can be used to assess affect in real time. Together, data collected from these sources provide the opportunity to further understand the role of affect in glucose levels.

Objective
This paper presents the protocol for a study that aims to (1) evaluate the feasibility and acceptability of using CGMs along with EMA in nondiabetic populations and (2) examine the bidirectional relationship between affect and glucose in nondiabetic adults with overweight or obesity using a CGM and EMA.

Methods
Eligibility criteria for the study include participants (1) aged 18 to 65 years old, (2) with a BMI of ≥25 kg/m2, (3) who are able to read and write in English, and (4) who own a smartphone. Individuals will be excluded if they (1) have type 1 or 2 diabetes or have any other condition that requires glucose monitoring, (2) are pregnant, (3) use any medications that have the potential to alter blood glucose levels or interfere with the glucose sensing process, or (4) have a diagnosed gastrointestinal condition or eating disorder. In a 14-day observational study, participants will wear a FreeStyle Libre Pro CGM sensor (Abbott) and will receive mobile phone–based EMA prompts 6 times per day (randomly within six 2-hour windows between 8 AM and 8 PM) to assess positive and negative affect. Participants will also wear a Fitbit Inspire 2 (Fitbit) to continuously monitor physical activity and sleep, which will be included as covariates in the analysis. Multilevel linear regression models will be used to evaluate the acute relationship between glucose level and affect.

Results
Recruitment started in October 2022 and is expected to be completed in March 2023. We will aim to recruit 100 participants. As of December 12, 2022, a total of 39 participants have been enrolled.

Conclusions
The results of this study will further elucidate the role of affect in glucose variability. By identifying affective states that may lead to glucose excursions, our findings could inform just-in-time behavioral interventions by indicating opportunities for intervention delivery.

International Registered Report Identifier (IRRID)
DERR1-10.2196/45104
SEMENTES DE UMA ECONOMIA CAMPONESA, FEMINISTA E AGROECOLÓGICA PRESENTES NA PRÁTICA DOS QUINTAIS PRODUTIVOS DAS MULHERES CAMPONESAS DO MMC/SC
Authors: Ribeiro dos Santos Geneci , Aparecida Marques Siomara , Leandrini Josimeire Aparecida 
Published: January 2023

O principal objetivo é trazer o debate sobre a perspectiva da economia camponesa e feminista presente nas experiências de organização, formação, produção e manejo dos quintais produtivos Agroecológicos de mulheres camponesas, militantes, dirigentes que participam do Movimento de Mulheres Camponesas - MMC/SC. O artigo traz alguns elementos que foram discutidos e aprofundados na dissertação de mestrado intitulada “Quintais produtivos e o papel das mulheres camponesas para o fortalecimento da produção agroecológica: Um estudo das experiências desenvolvidas pelo – (MMC/ SC)”.[1] A metodologia da pesquisa foi de abordagem qualitativa, com base em entrevistas, observação participante e anotações em “caderno de campo.” A pesquisa teórica e as experiências práticas, vivenciadas no cotidiano pelas mulheres camponesas contribuíram para assim nesse artigo abordar questões e reflexões sobre a problemática da “economia invisível.” Nas considerações finais dialogamos sobre os desafios enfrentados pelo MMC/SC, para avançar na construção de outra economia baseada em novos principios. E também enfatizamos a importância dos processos formativos e organizativos do Movimento para avançar na visibilidade, reconhecimento e valorização dos trabalhos desempenhados pelas mulheres camponesas.
Sailors’ fear of the stigma of HIV/AIDS
Authors: Kolarova-Dimitrova M. 
Published: January 2023

Introduction. Seafarers face many occupational, health and psychosocial problems on a daily basis. Maritime as a profession has a special combination of conditions that have a strong impact on the spread of sexually transmitted diseases (STIs) and make prevention programs difficult to succeed.Objective. To study the attitudes towards sharing and attitudes towards HIV-positive people among seafarers in the workplace.Material and methods. 100 persons practicing the maritime profession were surveyed using an anonymous questionnaire, approved by the Commission on Scientific Ethics at the Medical University — Varna.The results were statistically processed with SPSS v. 20.0, using variation, comparison and correlation analyzes.Results and discussion. Most of the respondents have sufficient experience in their profession, have higher education and have an equal distribution in deck and machine command (41% each), 18% are from the executive staff. All respondents are adamant that they would share the result of the HIV test with their family or partner, with only 24.0% stating that they would share the positive result with colleagues and 26.0% with the employer. We found a significant difference (c2 39.47; p<0.001) and a moderate dependence (r=0.34; p=0.001) on the behavior of respondents regarding the sharing of the positive result of the HIV test with members of their professional environment (colleagues and managers).The sailors are afraid to work with HIV-seropositive colleagues because their knowledge about the prevalence, risk factors and perceptions about the transmission and prevention of HIV infection have a lot of gaps.Conclusion. Despite training from unions, medical organizations and governments, the dreaded myths about HIV/AIDS persist. The degree of ignorance of the reality around HIV/AIDS is directly proportional to the stigmatization of the problem.
Place of radical surgery in tuberculosis treatment of central nervous system in combination with HIV infection
Authors: Petrov C. I. , Novitskaya О. N. 
Published: January 2023

Objective. On the basis of own material determine the role of radical surgery methods in treating tubercular formations of the brain in HIV-infected patients.Materials and Methods. Studied: statistical forms of the SSPB of the IOKB from 2008 to 2020, FTBPR data from 2017 to 2020, nature of the disease in 56, long-term disease dynamics — in 8, the autopsy material of 331 dead and the biopsy — 9 patients operated on with central nervous system damage (CNS).Results and Discussion. The number of patients with tuberculous meningoencephalitis increases in the structure of in-patient facilities, case-fatality rate among them grows. Need for neurosurgical care among the survivors is 25%. Long-term monitoring of operatively treated patients shows their higher survival rate, significant clinical effect of surgery, lengthening of life, increase of CD4 lymphocytes by 2,7 times in 3,5 years after the surgery. Formation of restrictive processes around tuberculous lesion in CNS was noted when taking ART with low immune status.Conclusion. Radical removal of tubercular formations of CNS in HIV is reasonable.
Dietary Factors and All-Cause Mortality in Individuals With Type 2 Diabetes: A Systematic Review and Meta-analysis of Prospective Observational Studies
Authors: Barbaresko Janett , Lang Alexander , Szczerba Edyta , Baechle Christina , Beckhaus Julia , Schwingshackl Lukas , Neuenschwander Manuela , Schlesinger Sabrina 
Published: January 2023

BACKGROUND
Type 2 diabetes is a major health concern associated with mortality. Diet may influence the progression of diabetes; however, systematic reviews are lacking.

PURPOSE
This study systematically summarized the evidence on diet and all-cause mortality in individuals with type 2 diabetes.

DATA SOURCES
PubMed and Web of Science were searched until June 2022.

STUDY SELECTION
Prospective observational studies investigating dietary factors in association with all-cause mortality in individuals with type 2 diabetes were selected.

DATA SYNTHESIS
We identified 107 studies. Moderate certainty of evidence was found for inverse associations of higher intakes of fish (summary risk ratios per serving/week: 0.95; 95% CI 0.92, 0.99; n = 6 studies), whole grain (per 20 g/day: 0.84; 95% CI 0.71, 0.99; n = 2), fiber (per 5 g/day: 0.86; 95% CI 0.81, 0.91; n = 3), and n-3 polyunsaturated fatty acids (per 0.1 g/day: 0.87; 95% CI 0.82, 0.92; n = 2) and mortality. There was low certainty of evidence for inverse associations of vegetable consumption (per 100 g/day: 0.88; 95% CI 0.82, 0.94; n = 2), plant protein (per 10 g/day: 0.91; 95% CI 0.87, 0.96; n = 3), and for positive associations of egg consumption (per 10 g/day: 1.05; 95% CI 1.03, 1.08; n = 7) and cholesterol intake (per 300 mg/day: 1.19; 95% CI 1.13, 1.26; n = 2). For other dietary factors, evidence was uncertain or no association was observed.

CONCLUSIONS
Higher intake of fish, whole grain, fiber, and n-3 polyunsaturated fatty acids were inversely associated with all-cause mortality in individuals with type 2 diabetes. There is limited evidence for other dietary factors, and, thus, more research is needed.
Plasma Amino Acids in Early Pregnancy and Midpregnancy and Their Interplay With Phospholipid Fatty Acids in Association With the Risk of Gestational Diabetes Mellitus: Results From a Longitudinal Prospective Cohort
Authors: Yang Jiaxi , Wu Jing , Tekola-Ayele Fasil , Li Ling-Jun , Bremer Andrew A. , Lu Ruijin , Rahman Mohammad L. , Weir Natalie L. , Pang Wei Wei , Chen Zhen , Tsai Michael Y. , Zhang Cuilin 
Published: January 2023

OBJECTIVEWe prospectively evaluated plasma amino acids (AAs) in early pregnancy and midpregnancy and their interplay with phospholipid fatty acids (FAs) in association with gestational diabetes mellitus (GDM) risk.RESEARCH DESIGN AND METHODSFrom a longitudinal pregnancy cohort of 2,802 individuals, concentrations of 24 plasma AAs at 10–14 and 15–26 gestational weeks (GW) were assessed among 107 GDM case subjects and 214 non-GDM control subjects. We estimated adjusted odds ratios (OR) and 95% CI for the associations of plasma AAs and the joint associations of plasma AAs and phospholipid FAs with GDM risk, adjusting for risk factors including age, prepregnancy BMI, and family history of diabetes.RESULTSGlycine at 10–14 GW was inversely associated with GDM (adjusted OR [95% CI] per SD increment: 0.55 [0.39–0.79]). Alanine, aspartic acid, and glutamic acid at 10–14 GW were positively associated with GDM (1.43 [1.08–1.88], 1.41 [1.11–1.80], and 1.39 [0.98–1.98]). At 15–26 GW, findings for glycine, alanine, aspartic acid, and the glutamine–to–glutamic acid ratio were consistent with the directions observed at 10–14 GW. Isoleucine, phenylalanine, and tyrosine were positively associated with GDM (1.64 [1.19–2.27], 1.15 [0.87–1.53], and 1.56 [1.16–2.09]). All P values for linear trend were &lt;0.05. Several AAs and phospholipid FAs were significantly and jointly associated with GDM. For instance, the lowest risk was observed among women with higher glycine and lower even-chain saturated FAs at 10–14 GW (adjusted OR [95% CI] 0.15 [0.06, 0.37]).CONCLUSIONSPlasma AAs may be implicated in GDM development starting in early pregnancy. Associations of AAs with GDM may be enhanced in the copresence of phospholipid FA profile.
Erratum. 10. Cardiovascular disease and risk management: Standards of Care in Diabetes—2023. Diabetes Care 2023;46(Suppl. 1):S158–S190
Authors: ElSayed Nuha A. , Aleppo Grazia , Aroda Vanita R. , Bannuru Raveendhara R. , Brown Florence M. , Bruemmer Dennis , Collins Billy S. , Das Sandeep R. , Hilliard Marisa E. , Isaacs Diana , Johnson Eric L. , Kahan Scott , Khunti Kamlesh , Kosiborod Mikhail , Leon Jose , Lyons Sarah K. , Perry Mary Lou , Prahalad Priya , Pratley Richard E. , Seley Jane Jeffrie , Stanton Robert C. , Gabbay Robert A. ,   on behalf of the American Diabetes Association
Published: January 2023

Fig. 10.2 of the article cited above provides recommendations for the treatment of confirmed hypertension in people with diabetes. Due to a composition error, the initial blood pressure range for the left side of the algorithm was given as ≥140/90 and &lt;160/100 mmHg; the correct initial blood pressure range is ≥130/80 and &lt;160/100 mmHg.
The online version of the article (https://doi.org/10.2337/dc23-S010) has been updated to correct the error.
Plasma amino acids in early and mid-pregnancy and their interplay with phospholipid fatty acids in association with the risk of gestational diabetes mellitus: results from a longitudinal prospective cohort
Authors: Yang Jiaxi , Wu Jing , Tekola-Ayele Fasil , Li Ling-Jun , Bremer Andrew A. , Lu Ruijin , Rahman Mohammad L. , Weir Natalie L. , Pang Wei Wei , Chen Zhen , Tsai Michael Y. , Zhang Cuilin 
Published: January 2023

<p> </p>
<p><strong>Objective </strong>We prospectively evaluated plasma AAs in early and mid-pregnancy and their interplay with phospholipid fatty acids (FAs) in association with GDM risk. </p>
<p><strong>Research Design and Methods</strong> From a longitudinal pregnancy cohort of 2,802 individuals, concentrations of 24 plasma AAs at 10-14 and 15-26 gestational weeks (GW) were assessed among 107 GDM cases and 214 non-GDM controls. We estimated odds ratios (aORs) and 95% confidence intervals (CIs) for the associations of plasma AAs and the joint associations of plasma AAs and phospholipid FAs with GDM risk, adjusting for risk factors including age, pre-pregnancy body mass index, and family history of diabetes. </p>
<p><strong>Results </strong>Glycine at 10-14 GW was inversely associated with GDM (aOR [95% CI] per standard deviation (SD) increment: 0.55 [0.39-0.79]). Alanine, aspartic acid, and glutamic acid at 10-14 GW were positively associated with GDM (1.43 [1.08-1.88], 1.41 [1.11-1.80], and 1.39 [0.98-1.98]). At 15-26 GW, findings for glycine, alanine, aspartic acid, and glutamine-to-glutamic acid-ratio were consistent with the directions observed at 10-14 GW. Isoleucine, phenylalanine, and tyrosine were positively associated with GDM (1.64 [1.19-2.27], 1.15 [0.87-1.53], and 1.56 [1.16-2.09]). All <em>p</em>-values for linear trend<0.05. Several AAs and phospholipid FAs were significantly and jointly associated with GDM. For instance, the lowest risk was observed among women with higher glycine and lower even-chain saturated FAs at 10-14 GW (aOR [95% CI]: 0.15 [0.06, 0.37]). </p>
<p><strong>Conclusions </strong>Plasma AAs may be implicated in GDM development starting in early pregnancy. Associations of AAs with GDM may be enhanced in the co-presence of phospholipid FA profile.</p>
Approaches to Develop Digital Competences to Create a Portrait of the Graduate of the Future
Authors: Menshikova Irina P. , Beloborodov Petr I. , Primakova Irina N. , Glazyrin Аlexey V. , Teplov Dmitriy V. , Shipareva Kseniya V. 
Published: January 2023

The purpose of this article is to analyze pedagogical technologies that are used to develop digital competencies and digital literacy in primary, middle, and high schools. Analysis of the problem field of research shows that increasing modernization of the industry associated with the processes of digitalization and automatization of technological lines to significant changes in the labor market, as well as adjustments in the portraits of graduates of both schools and higher education institutions. Transformation to an information and digital society causes other ways of presenting information as well as an emphasis on the development of relevant universal competences: critical and analytical types of thinking; ability to work and systematize large volumes of information; leadership skills, as well as the basics of time-management for organizing and planning independent work. The novelty of the work lies in the description of the real experience of modernization of the educational process in the private educational organization "Funscool", evaluation of the advantages and disadvantages of applied technologies compared to similar examples in secondary education in Russia or Europe, USA. At the same time, the analysis was carried out both for real-time and distance learning formats. Research methodology and methods: in writing the article methods of induction and deduction, methods of comparative analysis and synthesis of information were used, the analysis of various forms of questionnaire survey was carried out.