bluuebunny/crossref_metadata_2025_split huggingface dataset:
Modeling the dynamics of social preparedness with regional interactions to explore efficient flood early warning systems
Authors: Kotani Hitomu , Ogawa Wataru , Matsushima Kakuya , Susaki Junichi , Sawada Yohei 
Published: August 2023

Abstract

Flood early warning systems (FEWS) play a crucial role in mitigating flood damage. To optimize their effectiveness, it is important to understand how people respond to warnings and prepare for flooding events. The key factors influencing social preparedness include (1) direct and (2) indirect experiences of floods and (3) trust in warnings. However, existing socio-hydrological models do not incorporate all these elements. To include these elements for social preparedness, we propose a stylized model that allows multiple regions to influence one another (i.e., regional interactions). We investigate the dynamics of social preparedness in a society composed of regions with varying infrastructure levels (e.g., levee heights) and explore strategies for developing a socially efficient FEWS. Numerical analyses reveal that in a society that has a region characterized by a low infrastructure level (i.e., a region with frequent floods), regional interactions lead to a pronounced cry wolf effect due to false alarms from other regions, diminishing social preparedness in the low-infrastructure region. These interactions also prevent a warning strategy that optimizes the natural science-based index (i.e., threat score) from maximizing social efficiency. Conversely, in a society that has a region characterized by a high infrastructure level (i.e., a region with infrequent floods), regional interactions enhance the efficiency of FEWS by improving social preparedness through indirect experiences with floods. These findings suggest that as regional heterogeneity increases, it becomes increasingly vital for forecasters to consider social aspects (e.g., people's experiences, trust, and interactions) when establishing a socially efficient FEWS.
Enhanced Antitumor Effects of Thymoquinone in Combination with Paclitaxel on Hepatocellular Carcinoma Cell Lines: Role of P53 Modulation
Authors: Habib Tito N. 
Published: August 2023

Abstract
Background
Hepatocellular carcinoma (HCC) is a highly lethal disease with limited response to chemotherapy. Understanding the molecular mechanisms and drug resistance in HCC is crucial for developing effective therapeutic strategies. This study focuses on two widely used HCC cell lines, HepG2 and SNU-449, to investigate the combination treatment of paclitaxel (PTX) and thymoquinone (TQ). PTX is a potent chemotherapeutic agent that stabilizes microtubule structure and induces cell cycle arrest, but resistance remains a challenge. TQ has shown promising anticancer effects.
Methods
The antitumor effects of mono- and combined drug treatments were assessed in HepG2 and SNU-449 cell lines, including cell viability, cell cycle arrest, and apoptosis.
Results
The combination treatment synergistically enhanced the antitumor effects of PTX and TQ. It significantly reduced viable cell numbers, increased caspase-3 activation, and elevated annexin V staining. Interestingly, the combination induced differential cell cycle arrest patterns, with HepG2 cells shifting to the S phase and SNU-449 cells showing an increased G2/M cell population. PTX alone induced apoptosis in both cell lines, and TQ exhibited a similar apoptotic effect. The combined treatment further potentiated the apoptotic effect. P53, a tumor suppressor gene, was upregulated by PTX and/or TQ in the tested cell lines, suggesting its role in modulating the treatment response. P53 knockdown enhanced the antitumor properties of PTX and TQ in both cell lines.
Conclusion
The combination therapy of TQ and PTX holds promise as a potential therapeutic regimen for HCC. P53 may have a dual role, acting as a tumor suppressor and a cell protector under stress conditions. Targeting the down-regulatory mechanisms of P53 could be a valuable therapeutic approach, particularly in cancers with wild-type P53.
Kaposi’s sarcoma-associated herpes virus (KSHV) may not be associated with substance abuse in oral cancer patients: A retrospective case review.
Authors: Perera Manosha Lakmali , Perera Irosha Rukmali , Gunathilake Sharika , Silva Somila 
Published: August 2023

Abstract

Human Herpes virus 8 (HHV 8) better known as Kaposi’s sarcoma-associated herpes virus (KSHV) frequently relates to malignancies in acquired immune deficiency syndrome (AIDS) patients. Interestingly, one incident reported in a head and neck cancer patient who is also a HIV patient. In the light of these findings, this original research aimed to detect the HHV-8 status in oral squamous cell carcinoma tissues of Sri Lankan male patients. Incisional biopsies of cases were collected, transported, stored, and dispatched as frozen tissues at -800 C. A sub case sample selected from a large case control study to represent the vast majority of the oral cancer patients, in Sri Lankan context as oral cancer remains number 1 among Sri Lankan males. The DNA was extracted from frozen specimens using Gentra Puregene Tissue kit (Qiagen, Germany), solid tissue protocol according to the manufacturer’s instructions. The real-time PCR was performed with the specific primers to find out the possible association of this virus on substance abuse of OSCC patients in Sri Lanka. These data were obtained by a pre tested interviewer administered questioner were entered and analyzed using SPSS-21 Statistical Package. However, the HHV-8 DNA did not find in 22 OSCC cases. Kaposi’s sarcoma-associated herpes virus (KSHV) may not be associated with substance abuse in oral cancer patients. Powered longitudinal studies and invitro studies recommended to find out possible implication oral risk habits on this virus and activation of latent KSHV in B lymphocytes due to carcinogenic compounds in substances abused by OSCC patients.
Revisiting 2-Deoxyglucose Resistance in Neurospora crassa: Insights into Transcriptional Regulation of Hexose Transporters, Sugar Metabolism and Possible Modulation by Mating Type.
Authors: Pandey Rishikesh , Das Prabhu Kaibalya , Mishra Suruchee Samparna , Bulusu Vinay , Ramakrishnan Mukund 
Published: August 2023

Abstract

Background:
2-Deoxyglucose (2DG) has been used as an antimetabolite since the 1950s, however, mechanisms associated with its toxicity continue to be evaluated. Studies on 2-DG resistance in Neurospora have identified and characterized some mutants, including rco-3 (NCU02582) and exo-1 (NCU09899). Compared to yeast what is known in terms of genes and mechanisms, our knowledge of this phenomenon in filamentous fungi is still sketchy, though growing. We felt that examining, various aspects of Carbon Catabolite Repression for a certain group of dgr mutants might provide us with some insights.
Methods:
In the present manuscript, we have employed physiological as well as transcriptional approaches to better understand various properties associated with dgr strains vis-à-vis other known hexose transporter knockouts ∆ hgt-1 (NCU10021), ∆ hgt-2 (NCU04963), ∆ glt-1 (NCU01633) as well as glucose sensors such as ∆rco-3 (NCU02582), the dgr mutants included in this study are dgr-L1 ‘a’, dgr-L1 ‘A’, dgr (BEX5) ‘a’ and dgr (BEX6) ‘a’.
Results:
We make the following observations regarding the phenotypes associated with the dgr strains (i.e. including dgr(L1), dgr (BEX5) and dgr (BEX6)). (i) In conditions involving both low and high glucose we see altered expression associated with hexose transporters (glt-1, hgt-1 and hgt-2) as well as xylose metabolism regulators (xlr-1) (ii) We observe differential response as measured in terms of growth with regards to mating type (iii) We also observe differential sensitivity with regards to pH of the dgr mutants (iv) Finally we also propose a rapid method by which Glucose uptake can be monitored microscopically using the fluorescent analogue 2-NBDG used to successfully validate uptake in the dgr mutants used in this study.
Coping Strategies of the Inhabitants of Collaborative and Regular Housing Arrangements during the COVID-19 Pandemic: An Emerging Conceptual Re-elaboration of the Underlying Mechanisms through an Integrative Literature Review
Authors: Khatibi Maryam , Höpler Ruth , Aksumer Gizem 
Published: August 2023

Abstract

This review revisits the literature on collaborative and regular housing focusing on the intersection of housing affordability, social integration and health during the COVID-19 pandemic. Collaborative housing is an umbrella term that generates space not only for socio-spatial alternatives but also for alternative economic and legal frameworks in the context of housing. Hence, collaborative housing broadens the scope of regular housing by enabling the appropriation of common spaces by the inhabitants, encouraging social interaction, promoting sharing practices, self-organisation and collective solidarity in everyday life. Little is known about the challenges, experiences and mechanisms underlying the coping ways by which inhabitants dealt with the COVID-19 pandemic. Through an integrative literature review methodology, this study explores (1) How was unwanted isolation experienced during the COVID-19 pandemic?, (2) How did residents cope with the pandemic?, and (3) Which spatial solutions contributed to their well-being? This review includes 50 peer-reviewed articles, ten reports and 12 grey literature publications in three linguistic areas of English, German, and French in the timeframe of 2020–2022. Enriching the COVID-19 research in the context of housing, the review contributes to the synthesis of a state-of-the-art knowledge space by representing an emerged conceptual re-elaboration of coping responses in the context of regular and collaborative housing settings. Thus, the essence of this integrative review approach catalysed the unearthing of the underlying mechanisms of coping strategies and their causal explanations. Insights from various perspectives are extracted and organised to make them accessible to all while the elaboration for future research is identified.
On the Impact of Jaccard Fusion with Numerical Measures for Collaborative Filtering Enhancement
Authors: Amer Yasmeen A. , Abdalla Hassan I. , Nguyen Loc , Al-Maqaleh Basheer Mohamad 
Published: August 2023

Abstract

Collaborative filtering (CF) is an important method for recommendation systems, which are employed in many facets of our lives and are particularly prevalent in online-based commercial systems. The K-nearest neighbors (KNN) technique is a well-liked CF algorithm that uses similarity measurements to identify a user's closest neighbors in order to quantify the degree of dependency between the respective user and item pair. As a result, the CF approach is not only dependent on the choice of the similarity measure but also sensitive to it. However, some numerical measures, like cosine and Pearson, concentrate on the size of ratings, whereas Jaccard, one of the most frequently employed similarity measures, concerns the existence of ratings. Jaccard, in particular, is not a dominant measure, but it has long been demonstrated to be a key element in enhancing any measure. Therefore, in our ongoing search for the most effective similarity measures for CF, this research focuses on presenting combined similarity measures by fusing Jaccard with a multitude of numerical measures. Both existence and magnitude would benefit the combined measurements. Experimental results, on movielens-100K and Film Trust datasets, demonstrated that the combined measures are superior, surpassing all single measures across the considered assessment metrics.
Empirical association between COVID-19 confirmed cases, hospitalizations, vaccination, and travel: Comparison among different regions and provinces in Belgium between April-July 2021
Authors: Natalia Yessika Adelwin , Molenberghs Geert , Neyens Thomas , Hens Niel , Faes Christel 
Published: August 2023

Abstract

Objectives
In the absence of definitive treatment or vaccines, non-pharmaceutical interventions remain the major strategy to counter the COVID-19 pandemic. By the end of 2020, vaccines against COVID-19 had been developed and started as a preventive measure. In this study, we explored the effect of incoming travel rate combined with vaccination rate on COVID-19 incidence and hospitalization in Belgium between April-July 2021.
Methods
Data on COVID-19 confirmed cases and hospitalizations in Belgium were analyzed using a linear regression model (for data at the regional level) and a linear mixed model (for data at the provincial level).
Results
We found that incoming travel rate and vaccination rate have a significant effect on COVID-19 incidence and hospitalization at different administrative levels, provided appropriate transformations are applied and interactions added, suggesting non-linear effects of these explanatory variables.
Conclusion
Our findings suggest that surveillance on incoming travel would have been important to prevent COVID-19 transmission.
Turbulence modelling for depth-averaged velocity and boundary shear stress of a dense rigid grass bed open channel
Authors: Sahoo Sarjati , Khuntia Jnana Ranjan , Devi Kamalini , Sai Prasad B. Sree , Kumar Khatua Kishanjit 
Published: August 2023

Abstract
The present research focusses on a comparison of experimental and numerical approaches for flow over fixed artificial rigid grass bed channels. Various flow parameters like longitudinal velocity, depth-averaged velocity (DAV), boundary shear stress (BSS) and secondary current are analysed and compared with seven numerical models: standard, realizable and renormalization group (RNG) k–ε models and standard, shear stress transport (SST), generalized k–ω (GEKO) and Baseline (BSL) k–ω models. To evaluate the strength of the seven applied models, the error analysis has been performed. It is found that the RNG k–ε and SST k–ω models provided better results for both the DAV and BSS prediction, but the RNG k–ε model is found to be the most suitable for predicting the DAV and the SST k–ω model for BSS as compared to the other models. For the longitudinal velocity profiles, both the RNG k–ε and SST k–ω models are found to provide good agreement with experimental results at the centre of the channel, whereas the SST k–ω model is more accurate near the wall. Overall, the SST k–ω model has predicted the results with good accuracy for all the flow parameters considered in the present study.
Methodology for the study of the traceability of runoff water feeding reservoirs
Authors: Ortega Lidia M. , Ramos M. Isabel , Enríquez Turiño Carlos , José Cubillas Mercado Juan 
Published: August 2023

Abstract

Water reservoirs are essential to ensure water supply to both the population and agriculture, especially in the Mediterranean basin. In some cases, analyses of water intended for human consumption have detected high levels of agrochemicals. Knowing the possible origin of these products is complex because there may be many agricultural plots within the reservoir basin. In this paper, we introduce a methodology to obtain the set of agricultural plots whose rainwater reaches the reservoir and in what proportion they affect the points where chemical analyses are performed. The method implements an extension of the D8 algorithm for the calculation of the drainage network, in which additional information about the land-use type of the area, as well as rainfall maps, are also considered. In order to facilitate the user's analysis of the data, a plugin has been implemented in QGIS. This allows usability and easy interaction with the visual information. The Rumblar reservoir basin, located in Andalusia (Spain) has been studied as a use case, surrounded by olive orchards. The result is a replicable methodology for any other water reservoir and for carrying out an individualized study of agricultural plots.
Assessment, classification and mapping of groundwater quality for agriculture in selected farm settlements of southwestern Nigeria
Authors: Folarin Gbolahan Muyiwa , Badmus Biodun Suraj , Akinyemi Olukayode Dewunmi , Idowu Olufemi Abiola , Oke Adebayo Olubukola , Omodele Taiwo , Badmus Ganiyu Olabode 
Published: August 2023

Abstract
Good water quality is very vital to the productivity and sustainability of irrigated agriculture. The suitability for irrigation of groundwater samples collected and analyzed during dry and wet seasons from Ajegunle, Akufo and Eruwa farm settlements of southwestern Nigeria were assessed using several irrigation water quality indices (IWQIs). The parameters were analyzed statistically and subjected to correlation. Seasonal spatial distribution maps were generated via GIS. All the water samples from the three farm settlements were found to be mostly soft, fresh, excellent, and suitable for irrigation in both seasons. Meanwhile, soluble sodium percentage (SSP) and Kelley's Ratio (KR) revealed them as unsuitable while other parameters showed different degrees of suitability for different samples from different farm settlements in different seasons. Significant correlations were seen between the selected parameters in both seasons. The distribution maps reveal the spatial distributions of selected parameters within Ajegunle and Akufo farm settlements. Utilizing these findings will enhance systematic groundwater exploitation for irrigation within the settlements. Furthermore, systematic irrigation management practices and crop choices, based on the concentrations and distribution of the parameters viz-a-viz crop requirements should be considered to limit potential dangers that may arise with the use of the water over a long period.
UMOWY SPADKOWE W EDYKCIE JUSTYNIANA 'DE ARMENIORUM SUCCESSIONE' Z 535 R.
Authors: Grebieniow Aleksander 
Published: August 2023

Prawo justyniańskie zawiera wiele świadectw wykorzystywania umów w sprawach dotyczących następstwa prawnego mortis causa. Jednym z przykładów jest mało znany Edykt Justyniana z 535 r. De Armeniorum successione. Edykt wydany został w celu politycznej i prawnej integracji Armenii z Cesarstwem, tak ważnej wobec stałego wówczas zagrożenia ze strony Sassanidów. Na marginesie głównych postanowień edykt zawiera wzmiankę o stosowaniu ugód, którymi nota bene skutecznie modyfikowano testamentowy porządek dziedziczenia już od okresu klasycznego, oraz o enigmatycznych „innych pacta”. Pozostałe źródła prawne mogą zawierać wskazówki, jakie porozumienia spadkowe miał na myśli cesarz Justynian. Wydaje się, że Ed. 3, potwierdzając lokalną praktykę prawną, wskazuje jednocześnie na jej podobieństwo do niezależnie wykształconej praktyki stosowania prawa rzymskiego w tym zakresie.
The Critical Function of microRNAs in Developing Resistance against 5-
Fluorouracil in Cancer Cells
Authors: Sheikhnia Farhad , Maghsoudi Hossein , Majidinia Maryam 
Published: August 2023

Abstract:
Although there have been significant advancements in cancer treatment, resistance and recurrence
in patients make it one of the leading causes of death worldwide. 5-fluorouracil (5-FU), an
antimetabolite agent, is widely used in treating a broad range of human malignancies. The cytotoxic
effects of 5-FU are mediated by the inhibition of thymidylate synthase (TYMS/TS), resulting in the
suppression of essential biosynthetic activity, as well as the misincorporation of its metabolites into
RNA and DNA. Despite its huge benefits in cancer therapy, the application of 5-FU in the clinic is
restricted due to the occurrence of drug resistance. MicroRNAs (miRNAs) are small, non-coding
RNAs that act as negative regulators in many gene expression processes. Research has shown that
changes in miRNA play a role in cancer progression and drug resistance. This review examines the
role of miRNAs in 5-FU drug resistance in cancers.
Electroacupuncture Pretreatment Alleviates Cerebral Ischemia-reperfusion Injury by Down-regulating Mir-155-5p
Authors: Li Xuejing , Wang Ying , Zhou Xiang , Wang Hui , Xu Jiang 
Published: August 2023

Background:
Increasing evidence shows that electroacupuncture pretreatment (EP)
plays a crucial role in cerebral ischemia-reperfusion (I/R) injury, and cerebral I/R injury is the most
serious complication of ischemic stroke treatment. The role of miR-155-5p in cerebral I/R injury
has been studied, but the regulation of EP on miR-155-5p has not been reported.

Methods:
The middle cerebral artery occlusion (MCAO) mice were used to investigate the role of
EP in cerebral I/R injury. Longa and modified neurological severity scores (mNSS) were used to
evaluate neurological impairment. HE staining and TUNEL staining were used to evaluate brain
injury. The expressions of miR-155-5p, Yin Yang 1 (YY1) and p53 were detected by qRT-PCR.
The expressions of related proteins were detected by western blot. The binding of YY1 to miR-
155-5p was verified by dual-luciferase reporter assay and chromatin immunoprecipitation (ChIP)
assay. Mice brain microvascular endothelial cells (BMECs) were isolated and cultured for in vitro
experiments. Oxygen-glucose deprivation/reoxygenation (OGD/R) was used to verify the role of
YY1, p53 and miR-155-5p in cerebral I/R injury in vitro.

Results:
MCAO modeling induced brain injury, apoptosis, and increased levels of miR-155-5p,
YY1, and p53. EP markedly alleviated brain injury and reduced levels of miR-155-5p, p53, and
YY1. miR-155 agomir markedly increased the expression of miR-155-5p and p53. miR-155 antagomir
decreased the levels of miR-155-5p and p53. Dual-luciferase reporter and ChIP assay verified
that YY1 regulated miR-155-5p expression. YY1 shNRA greatly decreased miR-155-5p and
p53. Inhibition of p53 decreased miR-155-5p expression. Both miR-155-5p inhibitor and YY1
shRNA promoted proliferation, inhibited apoptosis, and decreased levels of ICAM-1 and Eselectin
of OGD/R-treated BMECs. Inhibition of p53 strengthened the effect of miR-155-5p inhibitor
and YY1 shNRA on BMECs.

Conclusion:
Electroacupuncture pretreatment alleviates cerebral ischemia-reperfusion injury by
regulating the YY1/p53/miR-155-5p axis.
The Role of METTL3 in the Progression of Cardiac Fibrosis
Authors: Bolívar Samir , Pérez-Cantillo Marian , Monterroza-Torres Jassiris , Vásquez-Trincado César , Castellar-Lopez Jairo , Mendoza-Torres Evelyn 
Published: August 2023

Abstract:
Cardiac fibrosis is known as the expansion of the cardiac interstitium through excessive
deposition of extracellular matrix proteins; this process is performed by a multifunctional cell
known as the cardiac fibroblast. After the myocardial injury, these cells are activated as a repair
program, increase, and switch to a contractile phenotype, which is evidenced by an increase in alpha-
smooth muscle actin. Likewise, there is an increase in type I and III collagen, which are considered
profibrotic biomarkers. It is believed that one of the proteins involved in cardiac remodeling is
METTL3, which is the enzyme responsible for N6-methyladenosine (m6A) methylation, the most
common and abundant epigenetic modification of eukaryotic mRNA. This review focuses on recent
studies in which the possible role of METTL3 in the progression of fibrosis has been demonstrated,
mainly in cardiac fibrogenesis.