bluuebunny/crossref_metadata_2025_split huggingface dataset:
Eating disorder patients with and without PTSD treated in residential care: discharge and 6-month follow-up results
Authors: Brewerton Timothy D. , Gavidia Ismael , Suro Giulia , Perlman Molly M. 
Published: March 2023

Abstract
Introduction
We studied whether provisional posttraumatic stress disorder (PTSD) moderated discharge (DC) and 6-month follow-up (FU) outcomes of multi-modal, integrated eating disorder (ED) residential treatment (RT) based upon principles of cognitive processing therapy (CPT).

Methods
ED patients [N = 609; 96% female; mean age (± SD) = 26.0 ± 8.8 years; 22% LGBTQ +] with and without PTSD completed validated assessments at admission (ADM), DC and 6-month FU to measure severity of ED, PTSD, major depressive disorder (MDD), state-trait anxiety (STA) symptoms, and eating disorder quality of life (EDQOL). We tested whether PTSD moderated the course of symptom change using mixed models analyses and if ED diagnosis, ADM BMI, age of ED onset and LGBTQ + orientation were significant covariates of change. Number of days between ADM and FU was used as a weighting measure.

Results
Despite sustained improvements with RT in the total group, the PTSD group had significantly higher scores on all measures at all time points (p ≤ .001). Patients with (n = 261) and without PTSD (n = 348) showed similar symptom improvements from ADM to DC and outcomes remained statistically improved at 6-month FU compared to ADM. The only significant worsening observed between DC and FU was with MDD symptoms, yet all measures remained significantly lower than ADM at FU (p ≤ .001). There were no significant PTSD by time interactions for any of the measures. Age of ED onset was a significant covariate in the EDI-2, PHQ-9, STAI-T, and EDQOL models such that an earlier age of ED onset was associated with a worse outcome. ADM BMI was also a significant covariate in the EDE-Q, EDI-2, and EDQOL models, such that higher ADM BMI was associated with a worse ED and quality of life outcome.

Conclusions
Integrated treatment approaches that address PTSD comorbidity can be successfully delivered in RT and are associated with sustained improvements at FU. Improving strategies to prevent post-DC recurrence of MDD symptoms is an important and challenging area of future work.
Condition and characterization analysis of a twentieth century cultural heritage through non-destructive testing (NDT) methods: the case of the Sivas industry school ironworking atelier in Turkey
Authors: Pehlivan Gamze Fahriye 
Published: March 2023

Abstract
Before the conservation and restoration of many types of cultural heritage, it is necessary to perform careful examination. This study aimed to determine the original building state and deterioration by applying non-destructive testing (NDT) methods in the case of a heritage building. Another goal was to determine, via NDT methods, whether the limestones observed in this study of different forms, colours, and textures were truly different. The Sivas Industry School Ironworking Atelier, which constitutes the research object, is one of the important public buildings in the city of Sivas, Turkey. Within the scope of the study, non-destructive infrared thermography (IRT), Schmidt hammer rebound (SHR) tests, and X-ray fluorescence (XRF) spectroscopy were applied. Accordingly, through IRT, deteriorations, anomalies, and material differences were investigated, and via SHR testing, uniaxial compressive strength (UCS) estimates, strength levels and hardness classes of stones were obtained. Moreover, via XRF spectroscopy, characterization analysis of stones was conducted. The data obtained could provide information to establish a basis for subsequent conservation. The innovation of this study is that although the infrared thermography technique is typically used in the investigation of materials, it was revealed that another technique such as XRF analysis is needed to better determine whether stones that seem different based on IRT are actually different. With IRT technique, anomaly and material detorioration can be determined. In addition to these two techniques, SHR tests that are non-destructive methods are needed to think about mechanical features of the material. Therefore, when determining the conditions and for characterization analysis of a cultural heritage before restoration, different techniques should be jointly used to complement each other.
Effectiveness and safety of secukinumab in ankylosing spondylitis and psoriatic arthritis: a 52-week real-life study in an Italian cohort
Authors: Molica Colella Francesco , Zizzo Gaetano , Parrino Vincenzo , Filosa Maria Teresa , Cavaliere Riccardo , Fazio Francesco , Molica Colella Aldo Biagio , Mazzone Antonino 
Published: March 2023

Abstract
Background
Secukinumab has shown high efficacy in randomized controlled trials in both ankylosing spondylitis (AS) and psoriatic arthritis (PsA). Here, we investigated its real-life effectiveness and tolerability in a cohort of AS and PsA patients.

Methods
We retrospectively analyzed medical records of outpatients with AS or PsA treated with secukinumab between December 2017 and December 2019. ASDAS-CRP and DAS28-CRP scores were used to measure axial and peripheral disease activity in AS and PsA, respectively. Data were collected at baseline and after 8, 24, and 52 weeks of treatment.

Results
Eighty-five adult patients with active disease (29 with AS and 56 with PsA; 23 males and 62 females) were treated. Overall, mean disease duration was 6.7 years and biologic-naïve patients were 85%. Significant reductions in ASDAS-CRP and DAS28-CRP were observed at all time-points. Body weight (in AS) and disease activity status at baseline (particularly in PsA) significantly affected disease activity changes. ASDAS-defined inactive disease and DAS28-defined remission were achieved in comparable proportions between AS and PsA patients, at both 24 weeks (45% and 46%) and 52 weeks (65.5% and 68%, respectively); male sex was found an independent predictor of positive response (OR 5.16, P = 0.027). After 52 weeks, achievement of at least low disease activity and drug retention were observed in 75% of patients. Secukinumab was well-tolerated and only mild injection-site reactions were recorded in 4 patients.

Conclusion
In a real-world setting, secukinumab confirmed great effectiveness and safety in both AS and PsA patients. The influence of gender on treatment response deserves further attention.
Long-term outcome of interventional approaches for treatment of coronary artery fistulas: a retrospective cohort study in a great referral center
Authors: Tabib Avisa , Mortezaeian Hojjat , Mahdavi Mohammad , Khalili Yasaman , Haas Nikolaus A. , Mohammadhoseini Sepideh 
Published: March 2023

Abstract
Background
Despite the spontaneous regression of many cases of coronary artery fistulas (CAFs), symptomatic patients or cases with severe shunting may require therapeutic interventions. In the present study, we aimed to assess the outcome of treatment of CAFs using interventional approaches.

Methods
This retrospective cohort study was performed on 29 patients with CAFs that were referred to our tertiary center between 2009 and 2019. Baseline characteristics were collected by reviewing the hospital files, and the patients were followed up to assess long-term outcomes with a mean follow-up of 3.3 years.

Results
Overall, in 29 patients in our cohort study, 82.9% suffered from isolated CAFs and in the remaining cases, concurrent congenital abnormalities did exist. For treatment, coils (Cook, Pfm, Ev3) were used in 79.3%, ADO II(AGA) in 18.3%, vascular plug (AGA) in 3.4%, and a combination of coil/ vascular plug/amplatzer in 3.4%. Postoperative complications were reported in 4 patients as external iliac artery thrombosis, transient PSVT, ST-T wave changes and mild pericardial effusion that were all managed successfully with no adverse sequels. No coronary artery injury, device dislocation, dissection, ischemia or coronary dilatation occurred, and there was no death. As larger fistulas were treated by a retrograde approach through the right side of the heart, there was significant correlation between residual shunts and the mode of closure approach; the majority of the residual shunts occurred in patients in the retrograde approach group.

Conclusions
Trans-catheter approach for treating CAFs leads to appropriate long-term outcome with minimal potential side effects.
Mind the blind spot: lessons from fungal community sequencing in a plant–soil feedback experiment
Authors: Liu Mengshuai , Maciá-Vicente Jose G. , van Ruijven Jasper , van der Werf Wopke , Cui Zhenling , Zhang Fusuo , Song Chunxu , Mommer Liesje 
Published: March 2023

Abstract
Background
Plant–soil feedback (PSF) has gained increasing interest in agricultural systems. An important question is whether PSF differs between different cropping systems. Few attempts have yet been made to identify the pathogen species involved in negative PSF. Here, we hypothesize that the strength of negative PSF experienced by a crop species is determined by the relative abundance of host-specific soil-borne pathogenic fungi, that is in turn driven by the crop’s relative abundance (in time).

Methods
We performed a PSF experiment, with different soils originating from three cropping systems in the North China Plain and three crop species (wheat, maize, soybean) in a full factorial design. Soil fungal community composition and relative abundance of fungal (pathogen) species in each treatment was identified by metabarcoding using ITS (Internal Transcribed Spacer) sequencing.

Results
PSF ranged from negative for wheat, neutral to negative for soybean and neutral to positive for maize, but the former density of a crop in a particular cropping system did not affect the strength of PSF experienced by each of the three. No relationships between fungal pathogen abundance and PSF were found, but we did find a surprisingly large enrichment across steps of the experiment of Chaetomium spp., a known cellulose-degrading fungus. This may be explained by addition of filter paper on the bottom of the pots.

Conclusions
Our results suggest that the strength of PSF in these crops is not related to the relative abundance of specific fungal pathogens. However, we cannot rule out that our results were affected by the high abundance of one particular cellulose-degrading fungus. This highlights both the need to stop the practice of using filter paper in pot experiments, as well as the relevance of assessing the identity, relative abundance and potential functions of fungal taxa in PSF experiments.
Inca Religious Women in the Male Imagination
Authors: Covey R. Alan 
Published: March 2023

AbstractDuring the Spanish colonization of the Andes, enclosures housing Inca religious women became a near-universal topic for male writers, who used women's sexuality to debate Indigenous civilization, sovereignty, and morality. Eyewitness accounts emphasized enclosed women's labor, obscuring the sexual violence that the conquistadores perpetrated against them. In succeeding decades, the religious functions of women's enclosures inspired imperfect analogies that likened their occupants to Catholic nuns and vestal virgins. Spanish writers eventually incorporated Quechua terms for religious women (mamaconas) who served in temple complexes and oversaw the gendered training of chosen girls (acllas) in other enclosures. New details on women's enclosures appeared at the turn of the seventeenth century, including the first accounts of Christian men of Andean descent. The Inca Garcilaso de la Vega's 1609 chronicle synthesized Catholic, classical, and vernacular approaches, providing an authoritative source that subsequent authors consulted as they reduced Inca institutions to metaphors of gender subordination and conquest.
Aktualne problemy edukacji geograficznej na różnych etapach kształcenia
Authors: Rodzoś Jolanta 
Published: March 2023

Artykuł zawiera analizę problemów współczesnej polskiej edukacji geograficznej na poziomie szkolnym. Jego głównym celem jest zdiagnozowanie aktualnych problemów geografii szkolnej w Polsce i odpowiedź na pytanie, dlaczego traci ona swoje znaczenie edukacyjne i jakie mogą być konsekwencje tego procesu. W opracowaniu opisano symptomy obecnego kryzysu geografii szkolnej, a następnie dokonano analizy cech geografii jako przedmiotu nauczania i opisano jej relacje z geografią akademicką. Wyniki tych analiz przedstawione zostały w odniesieniu do zjawisk zachodzących w polskim systemie edukacji oraz na tle dyskusji o geografii szkolnej, jaka miała miejsce w końcu XX w. Zdiagnozowano szereg problemów, wśród których za najważniejsze uznano zbyt dużą pojemność treściową geografii szkolnej, pogłębiający się rozdźwięk pomiędzy geografią szkolną a geografią uniwersytecką, wadliwy system kształcenia nauczycieli oraz słabnące zapotrzebowanie na wiedzę geograficzną. W efekcie współoddziaływania wymienionych czynników sytuacja geografii szkolnej jest bardziej niekorzystna niż miało to miejsce na przełomie XX i XXI w. Dziedzina ta musi poszukiwać nowej tożsamości i jest zagrożona jako samodzielny przedmiot nauczania. Formalny podział geografii na dwie odrębne dyscypliny naukowe oraz kryzys studiów geograficznych potęgują tę trudną sytuację.
Przyszłość i perspektywy rozwoju edukacji geograficznej w świetle studiów literatury
Authors: Piróg Danuta 
Published: March 2023

Artykuł ma charakter przeglądowy. Prezentuje efekty klasycznej analizy piśmiennictwa poświęconego szeroko pojętej problematyce zmian prognozowanych w edukacji geograficznej. Badaniami objęto publikacje zamieszczone w czasopismach specjalistycznych i monografie tematyczne, które ukazały się w Polsce oraz na świecie w latach 2000–2022. Celem studiów literatury było ustalenie kierunków oraz zakresów zmian, które nastąpią w najbliższej przyszłości w szkolnym kształceniu geograficznym. Badania dowiodły, że problematyka ta cieszyła się w ostatnich dwóch dekadach nasilającym się naukowym zainteresowaniem wśród specjalistów zajmujących się badaniami nad edukacją geograficzną. Podejmowana przez nich tematyka ewaluowała od ujęć przeglądowo-kompleksowych ku analitycznym i dedykowanym konkretnym, ustalonym wcześniej, trendom zmian. Te dotyczyły przemian w zakresie treści kształcenia i koncepcji programowych, orientacji filozoficzno-pedagogicznych, metod i strategii, ewolucji roli nauczyciela, ewaluacji efektów, a także środowiska nauczania-uczenia się. Przegląd literatury jednoznacznie wskazuje, że wysokojakościowa edukacja geograficzna będzie w przyszłości koncentrować się na podejmowaniu bieżących i ważkich problemów społeczno-gospodarczych, realizowanych zgodnie z koncepcją kształcenia poszukującego i w duchu personalizmu. Obligatoryjnym modułem będzie edukacja sustensywna. Spluralizuje się znacznie miejsce realizacji i formy procesu kształcenia. Istotnej ewolucji ulegną rola i zadania nauczyciela, który będzie pełnił funkcję przewodnika i mentora edukacji geograficzno-przyrodniczej. W architekturze budynków szkolnych wzrośnie znaczenie estetyki, dostępności, bezpieczeństwa, wspólnych przestrzeni do edukacji, wypoczynku i socjalizowania się
Społeczna rola geografii jako nauki – wyniki badań empirycznych
Authors: Figlus Tomasz , Musiaka Łukasz , Wachecka-Kotkowska Lucyna , Włodarczyk Bogdan 
Published: March 2023

Artykuł prezentuje wyniki badań dotyczących społecznej roli geografii jako nauki. Badania te, wykonane techniką CAWI, objęły swym zasięgiem 1000 osób (nazwanych „Kowalskimi”) w ramach badań ogólnospołecznych oraz 102 ankietowanych zawodowo zajmujących się geografią na poziomie akademickim (nazwanych „Geografami”). W wariancie ogólnospołecznym określono pojmowanie geografii i jej przedmiotu badań oraz rozumienie jej roli, znaczenia i zadań, a także tego jak postrzegane są jej walory, mocne strony i słabości. Weryfikacji podlegała również praktyczna rola badanej dziedziny wiedzy i jej przydatność. Wśród „Geografów” badania objęły identyfikację sposobu rozumienia tożsamości geografii i jej cech konstytutywnych, percepcji zalet i słabości tej nauki, oceny procesu pogłębiającej się specjalizacji, ale też jej aplikacyjności oraz perspektyw rozwojowych. Z ankiet wynika, że respondenci mają pozytywny obraz geografii. Najczęstsze skojarzenia wśród „Kowalskich” cechuje płytkość, opisowość i powierzchowność. Geografia przez obie grupy respondentów postrzegana jest jako dziedzina wiedzy łącząca w sobie komponent przyrodniczy, społeczno-ekonomiczny oraz humanistyczny. Nie są zaskoczeniem opinie podkreślające duży walor utylitarny i aplikacyjny geografii. Zdaniem „Geografów” tożsamość tej nauki polega głównie na podejściu systemowym, całościowym, relacyjnym oraz na interdyscyplinarności. Znacząca część tej grupy respondentów potwierdza występowanie kryzysu tożsamości geografii. Jako niski postrzegany jest przez nich poziom jedności tej nauki. Podobnie słabo oceniony został poziom debaty nad stanem i kierunkami rozwoju.
Clinical efficacy of comprehensive rehabilitation intervention and its effect on Quality of Life in patients with Advanced Liver Cancer after Ultrasound-guided Microwave Ablation
Authors: Chen Dan , Yang Fan , Wang Xiu-ju , Zhao Jing 
Published: March 2023

Objective: To evaluate the clinical efficacy of comprehensive rehabilitation intervention and its effect on the quality of life (QoL) in patients with advanced liver cancer after ultrasound-guided microwave ablation (UMA).
Methods: This is a retrospective study. Total 110 in-patients with advanced liver cancer who had received UMA in our hospital from January 2019 to January 2021 were included and randomly divided into two groups. Patients in the control group received the conventional intervention and those in the experimental group received comprehensive rehabilitation intervention. The incidence of postoperative complications as well as the differences in indicators, including emotional status, QoL score, and patient satisfaction before and after the intervention were analyzed and compared between the two groups. The differences in survival between the two groups were compared.
Results: The incidence of postoperative complications in the experimental group was significantly lower than that of the control group. SAS and SDS scores of the experimental group were significantly decreased after intervention, while the control group had no significant change before and after intervention. KPS and SF-36 quality of life scores in the experimental group were significantly improved compared with the control group, and patient satisfaction was significantly higher than the control group, and the 12-month survival rate was significantly higher than that in the control group.
Conclusion: Comprehensive rehabilitation intervention can reduce the incidence of postoperative complications, improve the mood and QoL, and increase patient satisfaction and survival rate in patients with advanced liver cancer after UMA.
doi: https://doi.org/10.12669/pjms.39.3.6663
How to cite this: Chen D, Yang F, Wang X, Zhao J. Clinical efficacy of comprehensive rehabilitation intervention and its effect on Quality of Life in patients with Advanced Liver Cancer after Ultrasound-guided Microwave Ablation. Pak J Med Sci. 2023;39(3):809-814. doi: https://doi.org/10.12669/pjms.39.3.6663
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
The rise in trauma & orthopaedic trainee-led research and audit collaborative projects in the United Kingdom since the start of the COVID-19 pandemic
Authors: Khaleeq Tahir , Kabariti Rakan , Ahmed Usman 
Published: March 2023

Background and Objective: A significant increase has been observed globally in multi-centre trainee-led trauma & orthopaedic (T&O) research collaborative projects with more emphasis have been on tackling important research questions since the start of the COCID-19 pandemic. The objective of our analysis was to determine the number of trainee-led research collaborative projects in T&O in the United Kingdom that were started during the COVID-19 pandemic.
Methods: A retrospective analysis was conducted to determine how many trainee-led national collaborative projects in T&O were conducted since the start of the COVID-19 pandemic lockdown (March 2020 to June 2021) and the number of projects identified were compared to the previous year (2019). Any regional collaborative projects, projects that were started before the onset of COVID and projects of other surgical specialities were not included in the study.
Results: There were no projects identified in 2019 while in the Covid pandemic lockdown we identified 10 trainee-led collaborative trauma & orthopaedic projects with six of them being published with level of evidence from three to four.
Conclusion: Covid was unprecedented and has placed considerable trials across healthcare. Our study highlights an increase in multi-centre trainee-led collaborative projects within the UK and it underlines the feasibility of such projects especially with the advent of social media and Redcap® which facilitate recruitment of new studies and data.
doi: https://doi.org/10.12669/pjms.39.3.7417
How to cite this: Khaleeq T, Kabariti R, Ahmed U. The rise in trauma & orthopaedic trainee-led research and audit collaborative projects in the United Kingdom since the start of the COVID-19 pandemic. Pak J Med Sci. 2023;39(3):769-774. doi: https://doi.org/10.12669/pjms.39.3.7417
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Corrosion of copper nickel titanium archwire in chlorhexidine, sodium fluoride, and chitosan mouthwashes
Authors: Sufarnap Erliera , Harahap Kholidina Imanda , Adiana Ika Devi , Lim Davin , Lim Chatty , Christy Christy 
Published: March 2023

Background: Copper (Cu), nickel (Ni), chromium (Cr) ion release, and surface topography change from the orthodontic wire are the initial processes of corrosion that may affect the mechanical properties of the archwire. In this study, we aim to evaluate the effect of CHX, NaF, and chitosan on the corrosion of CuNiTi wire nickel and copper ions released, surface roughness change, and archwire deflection. Methods: Ninety samples of CuNiTi Tanzo™ archwires were divided into five groups according to their immersion solution: Artificial Saliva, CHX, NaF, CHX-NaF, and chitosan group. Each group was further divided into three subgroups (n=6) corresponding immersion time, i.e., two, four, and six weeks. The corrosion of the samples was analyzed with an atomic absorption spectrophotometer (AAS), scanning electron microscope (SEM), and universal testing machine (UTM). Results: The amount of nickel ion releases was increasing, but the copper ion releases were reduced by the time of observations. The highest nickel ion was released in the CHX-NaF group and the lowest in the chitosan group for six-week immersion. It also corresponded to the surface topography by SEM analysis which showed the most extended cracks and deep pits in the CHX-NaF group and a smoother surface in the chitosan group. Copper ion release showed the highest ion release in the NaF group and the lowest release in the chitosan group. The unloading force of CuNiTi archwire deflection remains the same at week two and week four for all mouthwashes. Conclusion: The use of mouthwashes that contained CHX, NaF, and chitosan could further alter the passive layer and cause higher nickel and copper ion release and increased CuNiTi archwire surface structure porosity. But there is no distinction between mouthwashes to release the unloading force within two until four weeks.