bluuebunny/crossref_metadata_2025_split huggingface dataset:
Historical and social science perspectives on food allergy
Authors: Smith Matthew 
Published: June 2023

AbstractThis article provides an overview of the insights social scientists, historians and other health humanities scholars have made to our understanding of food allergies. It shows how humanities and social science scholars have tended to address three pivotal issues related to food allergies: first, they have addressed the epidemiology of food allergies, including the apparent rise in the rate of food allergies and the emergence of theories that purport to explain why food allergies may be increasing. These include theories related to changes in food consumption and the hygiene hypothesis. Second, humanities and social science scholars have researched how risks related to food allergies have been constructed, understood, experienced and mitigated. Third, humanities and social science scholars have investigated the experiences of food allergy sufferers and those who care for them, providing valuable qualitative insights that can inform how we respond to food allergy and our understanding of the aetiology of food allergy. The article concludes with three recommendations. First, there should be a more interdisciplinary approach to food allergy research that involves social scientists and health humanities scholars. Second, humanities and social sciences scholars should be more willing to unpack and scrutinise the theories put forward to explain the aetiology of food allergies, rather than accepting them at face value. And finally, humanities and social sciences scholars can play a major role in ensuring that the experiences of patients and their carers are articulated and fed into debates about food allergy, including its causes and how to respond to it.
How Does the Regional Comprehensive Economic Partnership Affect the Restructuring of Global Value Chains?
Authors: Fan Zijie , Peng Siyi , Hu Wenjie 
Published: June 2023

AbstractThis paper quantifies the way in which the Regional Comprehensive Economic Partnership (RCEP) affects the restructuring of global value chains (GVCs). It incorporates an input– output structure into a general equilibrium model, highlighting important differences between intermediates and final goods. Using tariff reduction schedules for the RCEP agreement and Asian Development Bank Multi‐Region Input–Output database, it evaluates the impact of the RCEP's tariff cuts on vertical specialization and the GVC position index of members. It shows that the RCEP significantly increased vertical specialization and the weighted average number of stages for members for primary factors of production and final consumption, which led to more complex and longer production chains. This was mainly due to the trade creation in intermediates imported from member countries and those outside it. This is an important finding, distinct from traditional trade models without an input–output structure.
Molecular pharmacology in complement‐mediated hemolytic disorders
Authors: Bortolotti Marta , Barcellini Wilma , Fattizzo Bruno 
Published: June 2023

AbstractIn the last decade, a deeper understanding of the pathogenesis of complement mediated hemolytic disorders, such as paroxysmal nocturnal hemoglobinuria (PNH), cold agglutinin disease (CAD), warm type autoimmune hemolytic anemia (AIHA) with complement activation (wAIHA), and atypical hemolytic uremic syndrome (aHUS), paved the way to the therapeutic shift from purely supportive approaches to complement‐targeted therapies. This resulted in a significant improvement in disease management, survival, and quality of life. In this review, we will provide a snapshot of novel therapies for complement‐mediated hemolytic anemias with a focus on those ready to use in clinical practice. C5 inhibitors eculizumab and the long‐acting ravulizumab, are the established gold standard for untreated PNH patients, whilst the C3 inhibitor pegcetacoplan should be considered for suboptimal responders to anti‐C5 drugs. Several additional compounds targeting the complement cascade at different levels (other C5 inhibitors, factor B and D inhibitors) are under active investigation with promising results. In CAD, immunosuppression with rituximab remains the first‐line. However, recently FDA and EMA approved the anti‐C1s monoclonal antibody, sutimlimab, that showed dramatic responses and whose regulatory approval is soon awaited in many countries. Other drugs under investigation in AIHA include the C3 inhibitor pegcetacoplan, and the anti‐C1q ANX005 for warm AIHA with complement activation. Finally, aHUS is an indication for complement inhibitors. Eculizumab and ravulizumab have been approved, whilst other C5 inhibitors, and novel lectin pathway inhibitors are under active investigation in this disease.
Induction of IL‐32 in the immune response of keratinocytes to Mycobacterium marinum infection
Authors: Sang Xu , Xue Xiaotong , Mi Zihao , Wang Zhenzhen , Yu Xueping , Sun Lele , Ma Shanshan , Wang Zhe , Liu Hong , Zhang Furen 
Published: June 2023

AbstractKeratinocytes are the predominant cell type in the skin epidermis, and they not only protect the skin from the influence of external physical factors but also function as an immune barrier against microbial invasion. However, little is known regarding the immune defence mechanisms of keratinocytes against mycobacteria. Here, we performed single‐cell RNA sequencing (scRNA‐seq) on skin biopsy samples from patients with Mycobacterium marinum infection and bulk RNA sequencing (bRNA‐seq) on M. marinum‐infected keratinocytes in vitro. The combined analysis of scRNA‐seq and bRNA‐seq data revealed that several genes were upregulated in M. marinum‐infected keratinocytes. Further in vitro validation of these genes by quantitative polymerase chain reaction and western blotting assay confirmed the induction of IL‐32 in the immune response of keratinocytes to M. marinum infection. Immunohistochemistry also showed the high expression of IL‐32 in patients' lesions. These findings suggest that IL‐32 induction is a possible mechanism through which keratinocytes defend against M. marinum infection; this could provide new targets for the immunotherapy of chronic cutaneous mycobacterial infections.
Association of carnitine insufficiency with sarcopenia and dynapenia in patients with heart failure
Authors: Kinugasa Yoshiharu , Sota Takeshi , Nakamura Kensuke , Hirai Masayuki , Kato Masahiko , Yamamoto Kazuhiro 
Published: June 2023

AimL‐carnitine transports fatty acids into mitochondria and contributes to energy metabolism in skeletal muscles. However, the association between carnitine insufficiency and skeletal muscle weakness, namely sarcopenia and dynapenia, in patients with heart failure (HF) remains unclear.MethodsIn total, 124 patients with HF were enrolled in this study. Carnitine insufficiency was indicated by a decrease in serum free carnitine (FC) levels of less than 36 μmol/L or an elevated serum acylcarnitine (AC) to free carnitine (FC) ratio (AC/FC ratio) of 0.27 or higher. Skeletal muscle weakness was defined as reduced handgrip strength and classified into two phenotypes: sarcopenia (low muscle strength with low skeletal muscle mass) and dynapenia (low muscle strength with normal skeletal muscle mass).ResultsPatients with carnitine insufficiency had a significantly higher prevalence of muscle weakness and a lower 6‐min walk distance than those without carnitine insufficiency (P < 0.05). A machine learning model showed that older age (≥77 years) and, in patients aged 64–76 years, a higher AC/FC ratio (≥0.31) were associated with sarcopenia. However, there was only a week association between carnitine levels and dynapenia. The effect of carnitine insufficiency on skeletal muscle weakness was greater in patients with low skeletal muscle mass than in those with normal skeletal muscle mass (P < 0.05 for interaction).ConclusionsCarnitine insufficiency is more closely associated with sarcopenia than with dynapenia in patients with HF, suggesting carnitine insufficiency as a potential therapeutic target for sarcopenia in these patients. Geriatr Gerontol Int 2023; 23: 524–530.
Radiocesium transfer from soil is lower in tall fescue than orchardgrass under conditions of lower soil exchangeable potassium
Authors: Togamura Yasuko , Yamada Daigo , Shibuya Takeshi 
Published: June 2023

AbstractIn Japan, additional potassium fertilization is used as a countermeasure for radiocesium‐contaminated grasslands in the Tohoku and North Kanto regions. A 2‐year pot experiment was conducted to assess the efficacy of using tall fescue (Festuca arundinacea Schreb.), a low‐cesium‐absorption grass species, to replace orchardgrass (Dactylis glomerata L.), the most common forage grass species in these regions, to reduce potassium fertilization and improve the forage mineral balance. The treatments were a combination of two grass species (tall fescue and orchardgrass) and two potassium application rates (0 [K0] and three times the conventional amount [K3]) with four replications. The grass species and potassium application rate had significant (p < .001) effects on plant cesium‐137 concentrations. The results of the generalized linear mixed‐model analysis indicated that when tall fescue replaced orchardgrass, cesium‐137 in the forage grass was reduced to 34% and that the K3 treatment reduced cesium‐137 to 46% relative to the K0 treatment. The difference in cesium‐137 concentration between the two grass species increased as the soil exchangeable K2O content decreased. The equations for estimating the cesium‐137 concentration (y [g/kg]) from the exchangeable K2O content (x [g/kg]) were obtained as y = 63.7e–2.095x for tall fescue and y = 185.5e–3.327x for orchardgrass. These equations indicate that tall fescue cultivation can reduce the risk of elevated radioactive Cs in the grass by reducing potassium fertilizer to approximately half that of orchardgrass. There were no differences in the response of plant potassium concentrations or the potassium/(calcium + magnesium) equivalent ratio to soil exchangeable K2O content among the grass species. However, the mineral balance of forage can be improved by reducing potassium fertilizer applications for cesium‐137 remediation. Tall fescue has good potential to remediate contaminated grasslands as it reduces additional potassium fertilization and improves the mineral balance of forage.
My mum is on strike! Social reproduction and the (emotional) labor of ‘mothering work’ in neoliberal Britain
Authors: English Claire , Brown Gareth 
Published: June 2023

AbstractThis article will explore the ways mothers and carers use the term ‘emotional labor’ to describe the exhaustion and burnout associated with socially reproductive tasks, rather than the performance of affective labor in the workplace. Scholars of social reproduction theory claim that emotion is key to understanding the specificities of gendered alienation, yet it remains under‐theorised. This article seeks to understand how the emotional lives of carers have been transformed by neoliberal processes that have intensified labor both within and beyond the home. Drawing on interviews with participants from the 2019 ‘My Mum is on Strike’ stay and play event, alongside ethnographic insights from online mothering blogs, sometimes referred to as the ‘mamasphere’ (Wilson et al., 2017), this article seeks to contextualize the experiences of carers who narrate their reproductive labor as emotional ‘work’. Given the conditions of neoliberal rationality and the marketization of society, where every ‘field of activity… and entity (whether public or private, whether person, business, or state) is understood as a market and governed as a firm’ (Brown, 2015), emotional labor and the associated gendered expectations may begin to ‘feel like’ work, and we argue that this is felt in a specific way by those carrying out mothering labor, warranting further academic investigation.
Social participation and identity change during study abroad: British sojourners in China
Authors: Teng Mark Feng , Reynolds Barry Lee , Ha Xuan Van 
Published: June 2023

AbstractAn international experience usually influences language learners’ identity through social participation. This qualitative study examines a group of British students’ identity change in China. We conducted individual interviews and group discussions with eight participants. The analysis revealed that despite an outset perception of “otherness,” some students sought excitement and new experiences while others strengthened national identities. Students whose identity shifted toward the “open‐ended” took pride in their Chinese proficiency development and made use of “otherness” to build close and meaningful relationships. Students whose identity shifted toward a “self–other” orientation did not seek cultural experiences. These findings will inform international students and education providers to make the most use of study‐abroad opportunities and experiences to learn the culture and language of the host country.
Effects of dexmedetomidine on surgical site wound pain in patients undergoing laparoscopic cholecystectomy: A meta‐analysis
Authors: Weng Jinhui , Cheng Zhoujun , Li Shupeng 
Published: June 2023

AbstractThis study aimed to evaluate the effectiveness of dexmedetomidine as an adjuvant to local wound infiltration anaesthesia in reducing surgical site wound pain in patients undergoing laparoscopic cholecystectomy. The Cochrane Library, PubMed, EMBASE, China National Knowledge Infrastructure, and Wanfang databases were searched from the time of database creation until February 2023. We performed a randomised controlled trial on the effect of dexmedetomidine as an adjunct to local wound infiltration anaesthesia on postoperative wound pain in patients undergoing laparoscopic cholecystectomy. Two investigators independently screened the literature, extracted data, and evaluated the quality of each study. This study was performed using the Review Manager 5.4 software. Ultimately, 13 publications with 1062 patients were included. The results showed that dexmedetomidine was effective as an adjunct to local wound infiltration anaesthesia at 1 h (standardised mean difference [SMD]: −5.31, 95% confidence intervals [CIs]: −7.22 to −3.40, P < .001), 4 h (SMD: −3.40, P < .001), 12 h (SMD: −2.11, 95% CIs: −3.10 to −1.13, P < .001) and 24 h postoperatively (SMD: −1.98, 95% CIs: −2.76 to −1.21, P < .001) significantly reduced surgical site wound pain. However, there was no significant difference in the analgesic effect at 48 h postoperatively (SMD: −1.33, 95% CIs: −3.25 to −0.58, P = .17). Dexmedetomidine provided good postoperative wound analgesia at the surgical site when used for laparoscopic cholecystectomy.
RETRACTED: Intrawound vancomycin powder in orthopaedic surgery as surgical site wound infection prophylaxis: A meta‐analysis
Authors: Wang Bin , Li Songlin , Zhang Jinkang , Wu Di , Huang Xiaogang , Liu Dongzhou , Du Junjie 
Published: June 2023

AbstractA meta‐analysis research was executed to appraise the consequence of intrawound vancomycin powder (IWVP) in orthopaedic surgery (OPS) as surgical site wound infection (SSWI) prophylaxis. Inclusive literature research till March 2023 was carried out and 2756 interconnected researches were revised. Of the 18 picked researches enclosed 13 214 persons with OPS were in the used researches' starting point, 5798 of them were utilising IWVP, and 7416 were control. Odds ratio (OR) in addition to 95% confidence intervals (CIs) were used to appraise the consequence of the IWVP in OPS as SSWI prophylaxis by the dichotomous approaches and a fixed or random model. IWVP had significantly lower SSWIs (OR, 0.61; 95% CI, 0.50‐0.74, P < .001), deep SSWIs (OR, 0.57; 95% CI, 0.36‐0.91, P = .02), and superficial SSWIs (OR, 0.67; 95% CI, 0.46‐0.98, P = .04) compared with control in persons with OPS. IWVP had significantly lower SSWIs, deep SSWIs, and superficial SSWIs compared with control in persons with OPS. However, when interacting with its values, caution must be taken and more research is needed to confirm this finding.
The application of MDT model for calciphylaxis management in patients with end‐stage renal disease
Authors: Pan Yanyan , Wang Hui , Ye Yajun , Lv Manman , Zhu Yamei , Wang Ningning , Zhao Jing , Shi Jingping , Lv Xiaolin 
Published: June 2023

AbstractThis study focuses on the application of nurse‐led multidisciplinary collaborative therapy (MDT) management model for calciphylaxis prevention of patients with terminal renal disease. Through the establishment of a multidisciplinary management team spanning nephrology department, blood purification center, dermatology department, burn and plastic surgery department, infection department, stem cell platform, nutrition department, pain department, cardiology department, hydrotherapy group, dermatology group, and outpatient treatment room, the distribution of duties among team members were clarified to bring out the best advantages of a multidisciplinary teamwork during treatment and nursing. For patients with calciphylaxis symptoms in terminal renal disease, a case‐by‐case management model was carried out with the focus on personalised problem. We emphasised on personalised wound care, precise medication care, active pain management, psychological intervention and palliative care, the amelioration of calcium and phosphorus metabolism disorder, nutritional supplementation, and the therapeutic intervention based on human amniotic mesenchymal stem cell regeneration. The MDT model effectively compensates for traditional nursing mode and could serve as a novel clinical management modality for calciphylaxis prevention in patients with terminal renal disease.
Density‐modified structure and mechanical properties of amorphous Si2BC3N by ab initio molecular dynamics calculations
Authors: Liu Yuchen , Zhou Yu , Yang Zhihua , Li Daxin , Jia Dechang , Liu Bin 
Published: June 2023

AbstractDensity‐modified structural features and mechanical properties of the amorphous Si2BC3N are studied by ab initio molecular dynamics simulations. The chemical bonds of Si2BC3N are insensitive to the density variation, which is reflected by the negligible changes in bond lengths, peak locations in density of states and Bader charge values under different densities. Instead, the composition of chemical bonds is altered. Meanwhile, high‐density condition induces the transition of polyhedral units from the sp2‐like trigonal configuration to the tetrahedral configuration, especially for B, C, and N. This variation is the main structural responding mechanism of Si2BC3N to increased density, which is different from the stretching and/or shrinkage of bonds as occurred in crystals. The increased tetrahedron content shall further benefit the amorphous structure stability of Si2BC3N by impeding the separation of turbostratic BN(C), and enhance the second‐order elastic constants, elastic moduli and tensile/shear strengths of Si2BC3N. The high density may decrease the debonding capability of the fiber/Si2BC3N interface but will not change the preference for crack deflection at interfaces. These results suggest the promising prospect of mechanical property optimization of SiBCN ceramics through density tailoring in experiments.
M&A and technological expansion
Authors: Jin Ginger Zhe , Leccese Mario , Wagman Liad 
Published: June 2023

AbstractWe examine how public firms listed in North American stock exchanges acquire technology companies during 2010–2020. Combining data from Standard and Poor's (S&P), Refinitiv, Compustat, and Center for Research in Security Prices, and utilizing a unique S&P taxonomy that classifies tech mergers and acquisitions (M&As) by tech categories and business verticals, we show that 13.1% of public firms engage in any tech M&A in the S&P data, while only 6.75% of public firms make any (tech or nontech) M&A in Refinitiv. In both data sets, the acquisitions are widespread across sectors of the economy, but tech acquirers in the S&P data are on average younger, more investment efficient, and more likely to engage in international acquisitions than general acquirers in Refinitiv. Within the S&P data, deals in each M&A‐active tech category tend to be led by acquirers from a specific sector; the majority of target companies in tech M&As fall outside the acquirer's core area of business; and firms are, in part, driven to acquire tech companies because they face increased competition in their core areas.
TaTIP41 and TaTAP46 positively regulate drought tolerance in wheat by inhibiting PP2A activity
Authors: Ma Jianhui , Geng Yuke , Liu Hong , Zhang Mengqi , Liu Shujuan , Hao Chenyang , Hou Jian , Zhang Youfu , Zhang Daijing , Zhang Weijun , Zhang Xueyong , Li Tian 
Published: June 2023

AbstractDrought is a major environmental stress limiting global wheat (Triticum aestivum) production. Exploring drought tolerance genes is important for improving drought adaptation in this crop. Here, we cloned and characterized TaTIP41, a novel drought tolerance gene in wheat. TaTIP41 is a putative conserved component of target of rapamycin (TOR) signaling, and the TaTIP41 homoeologs were expressed in response to drought stress and abscisic acid (ABA). The overexpression of TaTIP41 enhanced drought tolerance and the ABA response, including ABA‐induced stomatal closure, while its downregulation using RNA interference (RNAi) had the opposite effect. Furthermore, TaTIP41 physically interacted with TaTAP46, another conserved component of TOR signaling. Like TaTIP41, TaTAP46 positively regulated drought tolerance. Furthermore, TaTIP41 and TaTAP46 interacted with type‐2A protein phosphatase (PP2A) catalytic subunits, such as TaPP2A‐2, and inhibited their enzymatic activities. Silencing TaPP2A‐2 improved drought tolerance in wheat. Together, our findings provide new insights into the roles of TaTIP41 and TaTAP46 in the drought tolerance and ABA response in wheat, and their potential application in improving wheat environmental adaptability.
The neuroanatomy and pneumaticity of Hamadasuchus (Crocodylomorpha, Peirosauridae) from the Cretaceous of Morocco and its paleoecological significance for altirostral forms
Authors: Pochat‐Cottilloux Yohan , Rinder Nicolas , Perrichon Gwendal , Adrien Jérôme , Amiot Romain , Hua Stéphane , Martin Jeremy E. 
Published: June 2023

AbstractWe describe the endocranial structures of Hamadasuchus, a peirosaurid crocodylomorph from the late Albian‐Cenomanian Kem Kem group of Morocco. The cranial endocast, associated nerves and arteries, endosseous labyrinths, and cranial pneumatization, as well as the bones of the braincase of a new specimen, are reconstructed and compared with extant and fossil crocodylomorphs, which represent different lifestyles. Cranial bones of this specimen are identified as belonging to Hamadasuchus, with close affinities with Rukwasuchus yajabalijekundu, another peirosaurid from the ‘middle’ Cretaceous of Tanzania. The endocranial structures are comparable to those of R. yajabalijekundu but also to baurusuchids and sebecids (sebecosuchians). Paleobiological traits of Hamadasuchus, such as alert head posture, ecology, and behavior are explored for the first time, using quantitative metrics. The expanded but narrow semi‐circular canals and enlarged pneumatization of the skull of Hamadasuchus are linked to a terrestrial lifestyle. Continuing work on the neuroanatomy of supposedly terrestrial crocodylomorphs needs to be broadened to other groups and will allow to characterize whether some internal structures are affected by the lifestyle of these organisms.