bluuebunny/crossref_metadata_2025_split huggingface dataset:
GRB2 dimerization mediated by SH2 domain-swapping is critical for T cell signaling and cytokine production
Authors: Sandouk Aline , Xu Zhen , Baruah Sankar , Tremblay Mikaela , Hopkins Jesse B. , Chakravarthy Srinivas , Gakhar Lokesh , Schnicker Nicholas J. , Houtman Jon C. D. 
Published: March 2023

AbstractGRB2 is an adaptor protein required for facilitating cytoplasmic signaling complexes from a wide array of binding partners. GRB2 has been reported to exist in either a monomeric or dimeric state in crystal and solution. GRB2 dimers are formed by the exchange of protein segments between domains, otherwise known as “domain-swapping”. Swapping has been described between SH2 and C-terminal SH3 domains in the full-length structure of GRB2 (SH2/C–SH3 domain-swapped dimer), as well as between α-helixes in isolated GRB2 SH2 domains (SH2/SH2 domain-swapped dimer). Interestingly, SH2/SH2 domain-swapping has not been observed within the full-length protein, nor have the functional influences of this novel oligomeric conformation been explored. We herein generated a model of full-length GRB2 dimer with an SH2/SH2 domain-swapped conformation supported by in-line SEC–MALS–SAXS analyses. This conformation is consistent with the previously reported truncated GRB2 SH2/SH2 domain-swapped dimer but different from the previously reported, full-length SH2/C-terminal SH3 (C–SH3) domain-swapped dimer. Our model is also validated by several novel full-length GRB2 mutants that favor either a monomeric or a dimeric state through mutations within the SH2 domain that abrogate or promote SH2/SH2 domain-swapping. GRB2 knockdown and re-expression of selected monomeric and dimeric mutants in a T cell lymphoma cell line led to notable defects in clustering of the adaptor protein LAT and IL-2 release in response to TCR stimulation. These results mirrored similarly-impaired IL-2 release in GRB2-deficient cells. These studies show that a novel dimeric GRB2 conformation with domain-swapping between SH2 domains and monomer/dimer transitions are critical for GRB2 to facilitate early signaling complexes in human T cells.
A study on disability glare vision in young adult subjects
Authors: Casado Pilar , Ávila Francisco J. , Collados Mª Victoria , Ares Jorge 
Published: March 2023

AbstractThe full assessment of the visual system must include the evaluation of the optical quality of the eye and neural visual functions. The objective evaluation of the retinal image quality is often carried out by computing the point spread function (PSF) of the eye. The central part of the PSF is associated with optical aberrations and the peripheral areas with scattering contributions. In that sense, visual acuity and contrast sensitivity function tests can be considered the perceptual neural response to those contributions characterizing the eye’s PSF. However, in natural viewing conditions, visual acuity tests may provide good vision while contrast sensitivity tests can reveal visual impairment in glare vision conditions, such as exposure to bright light sources or night driving conditions. Here we present an optical instrument for the study of disability glare vision under extended Maxwellian illumination to assess the contrast sensitivity function under glare conditions. The limit of the Total Disability Glare threshold, tolerance, and glare adaptation will be investigated as a function of the angular size of the glare source (GA) and the contrast sensitivity function in young adult subjects.
Risk factors for totally implantable access ports-associated thrombosis in pediatric oncology patients
Authors: Lan Yingxia , Wu Liuhong , Guo Jin , Wang Juan , Guan Huijie , Li Baihui , Liu Longzhen , Zhang Lian , Hong Ye , Deng Jun , Zhu Jia , Lu Suying , Sun Feifei , Huang Junting , Sun Xiaofei , Zhang Yizhuo , Wang Jian , Cai Ruiqing 
Published: March 2023

AbstractThe application of totally implantable access ports (TIAPs) reduces treatment-related discomfort; however, the existence of catheter may cause side effects, with the most common one being the occurrence of TIAPs-associated thrombosis. The risk factors for TIAPs-associated thrombosis in pediatric oncology patients have not been fully described. A total of 587 pediatric oncology patients undergoing TIAPs implantation at a single center over a 5-year period were retrospectively analyzed in the present study. We investigated the risk factors for thrombosis, emphasizing the internal jugular vein distance, by measuring the vertical distance from the highest point of the catheter to the upper border of the left and right extremitas sternalis claviculae on chest X-ray images. Among 587 patients, 143 (24.4%) had thrombosis. Platelet count, C-reactive protein, and the vertical distance from the highest point of the catheter to the upper border of the left and right extremitas sternalis claviculae were demonstrated to be the main risk factors for the development of TIAPs-associated thrombosis. TIAPs-associated thrombosis, especially asymptomatic events, is common in pediatric cancer patients. The vertical distance from the highest point of the catheter to the upper border of the left and right extremitas sternalis claviculae was a risk factor for TIAPs-associated thrombosis, which deserved additional attention.
A system for in-situ, wave-by-wave measurements of the speed and volume of coastal overtopping
Authors: Yelland Margaret J. , Brown Jennifer M. , Cardwell Christopher L. , Jones David S. , Pascal Robin W. , Pinnell Richard , Pullen Tim , Silva Eunice 
Published: March 2023

AbstractWave overtopping of sea defences poses a hazard to people and infrastructure. Rising sea levels and limited resources mean accurate prediction tools are needed to deliver cost-effective shoreline management plans. A dearth of in-situ data means that the numerical tools used for flood forecasting and coastal scheme design are based largely on data from idealised flume studies, and the resulting overtopping predictions may have orders of magnitude uncertainty for complicated structures and some environmental conditions. Furthermore, such studies usually only provide data on the total volume of overtopping water, and no data on the speed of the water. Here we present WireWall, an array of capacitance-based sensors which measure the speed and volume of overtopping water on a wave-by-wave basis. We describe the successful validation of WireWall against traditional flume methods and present results from the first trial deployments at a sea wall in the UK. WireWall results are also compared with numerical predictions based on EurOtop guidance. WireWall technology offers an approach for reliable acquisition of the data needed to develop resilient coastal protections schemes.
A special issue in Essays in Biochemistry on astrocytes—more than a neuronal support network
Authors: Bolaños Juan P. 
Published: March 2023

Abstract
Astrocytes are a type of non-neuronal, glial cells, anatomically placed in the intersection between the brain blood vessels and other neural cells—including neurons. Such a strategic situation confers these cells a unique opportunity to sense circulating molecules and adapt according to different organismal conditions. By acting as sentinel cells, astrocytes thus co-ordinate gene expression profiles, immune responses, signal transduction pathways, and metabolic programs that play essential roles in the formation of brain circuits to modulate neurotransmission and higher-order organismal functions.
THz imaging enhancement based on Noise2Noise algorithm
Authors: Wang Tianhe , Huang Xuejun , Ding Jinshan , Zhang Yuhong 
Published: March 2023

AbstractTerahertz (THz) imaging has an outstanding advantage of high resolution due to the high frequency and has promising potential in VideoSAR. However, limited to the THz source power and the air absorption, the THz image usually has a low SNR and is susceptible to noise in remote sensing and imaging. In order to improve the quality of THz images, a THz image enhancement method is proposed based on the noise2noise strategy. The THz images are reconstructed using the AFBP algorithm. They are organized as noisy image pairs and filtered with a mask to remove the influence of moving targets. Then, the Noise2Noise network is constructed based on the CNN network and takes the noisy image pair as input and reference. In the training stage, 1000 noisy image pairs are used as the training set and 100 noisy images are used as the test set to verify the performance of the proposed method. The experimental results of real VideoSAR data have demonstrated that the proposed method is capable of suppressing noise and enhancing the THz image.
High temperature energy storage and release properties of polyimide nanocomposites simulated by considering charge trapping effects
Authors: Wang Poxin , Min Daomin , Song Xiaofan , Gao Ziwei , Hao Yutao , Wang Shihang , Liu Wenfeng 
Published: March 2023

AbstractDielectric energy storage capacitors with excellent high temperature resistance are essential in fields such as aerospace and pulse power. However, common high‐temperature resistant polymers such as polyimide (PI) and polyether sulfone have low energy storage densities and energy efficiencies at high temperature, which are greatly limited in practical applications. The polymer nanocomposites prepared by doping modification can regulate the charge injection and transport process, and improve the high‐temperature energy storage performance. However, the quantitative relationship between charge injection and charge trapping and the energy storage performance of linear polymer nanocomposites still needs further study. An energy storage and release model considering the charge trapping effects is constructed by the authors. We simulate the high‐temperature energy storage properties of polyimide nanocomposite dielectrics (PI PNCs) with different charge injection barriers and trap parameters at 150°C. A triangular voltage is applied to the electrodes at both sides of the PI PNCs, the electric displacement‐electric field loop is simulated, and the discharged energy densities and energy efficiencies are calculated. The simulation results are consistent with the experimental results. Increasing the charge injection barrier, deep trap energy and deep trap density can effectively reduce the charge injection and the carrier mobility, thereby improving the discharged energy densities and energy efficiencies of dielectric capacitors. In the case of low charge injection barrier (1.3 eV), with the increase of deep trap energy (0.7–1.5 eV) and deep trap density (1 × 1021–1 × 1025 m−3), the discharged energy density changes from 0.20 to 1.44 Jcm−3, the energy efficiency changes from 9.0% to 99.9%, and the high‐temperature energy storage performance improves significantly. This research provides theoretical and model support for the improvement of the high‐temperature energy storage performance of nanocomposites.
Assessment of energy losses in power distribution systems with individual prosumers and energy communities
Authors: Diahovchenko Illia , Petrichenko Lubov 
Published: March 2023

AbstractAchieving the energy transition target will require the extensive engagement of consumers and the private sector in investment and operation of renewable‐based power systems. Support of individual prosumers and proliferation of energy communities are efficient ways to implement this engagement. To facilitate smooth integration of prosumers with photovoltaic (PV) installations, while satisfying effective operation of the power distribution system (PDS), it is important to fundamentally assess energy losses for different grid development scenarios. In this paper, the energy losses are compared for two alternatives: (a) when prosumers with PV installations act as individual grid users, and (b) when prosumers become participants of a solar energy community. To achieve this goal, modeling of loads, prosumers’ behavior and PV generation was performed. Furthermore, it has been analyzed how the physical topology of the distribution network can be harmonized with the underlying bidirectional power flows for each alternative, while complying with system constraints. The IEEE 123 Node Test Feeder was employed to capture the performance of the PDS and to estimate the energy loss with various penetration levels of prosumers. The results indicate that reduction of energy losses is only possible until a certain PV penetration level, after which additional PV capacities cause increase in energy losses and complicate the PDS's operation. Lower energy losses were supervised for the cases with dispersed PV generation, compared to the cases focused on energy communities. This means that the PDS demonstrates better tolerance to evenly distributed prosumers, rather than to single sources of a larger scale installed in one node. The outputs of this study will help the energy planners and utilities in improving performance of the PDS in terms of loss minimization and loadability maximization.
Disk Evolution Study Through Imaging of Nearby Young Stars (DESTINYS): Diverse outcomes of binary–disk interactions
Authors: Zhang Yapeng , Ginski Christian , Huang Jane , Zurlo Alice , Beust Hervé , Bae Jaehan , Benisty Myriam , Garufi Antonio , Hogerheijde Michiel R. , van Holstein Rob G. , Kenworthy Matthew , Langlois Maud , Manara Carlo F. , Pinilla Paola , Rab Christian , Ribas Álvaro , Rosotti Giovanni P. , Williams Jonathan 
Published: March 2023

Context. Circumstellar disks play an essential role in the outcomes of planet formation. Disks do not evolve in isolation, as about half of solar-type stars were born in binary or multiple systems. The presence of stellar companions modifies the morphology and evolution of disks, potentially resulting in a different planet population. Resolving disks in binary systems provides the opportunity to examine the influence of stellar companions on the outcomes of planet formation.
Aims. We aim to investigate and compare disks in stellar multiple systems with near-infrared scattered-light imaging as part of the Disk Evolution Study Through Imaging of Nearby Young Stars (DESTINYS) large program. In particular, we present observations of circumstellar disks in three systems, namely, CHX 22, S CrA, and HP Cha.
Methods. We used polarimetric differential imaging with SPHERE/IRDIS at the VLT to search for scattered light from the circum-stellar disks in these multiple systems. We performed astrometric and orbit analyses for the stellar companions using archival HST, VLT/NACO, and SPHERE data to better understand the interplay between disks and companions.
Results. Combined with the age and orbital constraints, the observed disk structures in scattered light provide insights into the evolutionary history and the impact of the stellar companions. The small grains in CHX 22 form a tail-like structure surrounding the close binary, which likely results from a close encounter and capture of a cloudlet. S CrA shows intricate structures (tentative ringed and spiral features) in the circumprimary disk as a possible consequence of perturbations by companions. The circumsecondary disk is truncated and connected to the primary disk via a streamer, suggesting tidal interactions. In HP Cha, the primary disk is less disturbed and features a tenuous streamer, through which the material flows toward the companions.
Conclusions. The comparison of the three systems spans a wide range of binary separation (50–500 au) and illustrates the decreasing influence on disk structures with the distance of companions. This agrees with the statistical analysis of the exoplanet population in binaries, that planet formation is likely obstructed around close binary systems, while it is not suppressed in wide binaries.
Intraoperative Azetabulumfraktur
Authors: Hipfl Christian , Perka Carsten 
Published: March 2023

ZusammenfassungDie intraoperative Azetabulumfraktur ist eine seltene Komplikation in der
Hüfttotalendoprothetik. Sie tritt hauptsächlich als Folge der Impaktion einer zementfreien
Press-fit-Pfanne auf. Risikofaktoren sind eine verminderte Knochenqualität, ein stark
sklerotischer Knochen und ein zu groß gewähltes Press-fit. Der Zeitpunkt der Diagnose bestimmt
das therapeutische Vorgehen. Intraoperativ erfasste Frakturen sollten immer mit einer
entsprechenden Stabilisierung behandelt werden. Postoperativ entscheidet die Stabilität der
Implantate sowie der Fraktur darüber, ob zunächst ein konservatives Behandlungsprozedere
möglich ist. Die meisten intraoperativ diagnostizierten Azetabulumfrakturen sind mit einer
Multi-Hole-Pfanne mit zusätzlichen in den unterschiedlichen Azetabulumregionen verankernden
Schrauben zu versorgen. Bei großen Hinterwandfragmenten oder einer Beckendiskontinuität ist
primär eine Plattenosteosynthese des hinteren Pfeilers indiziert. Alternativ kann eine
Cup-Cage-Rekonstruktion zur Anwendung kommen. Insbesondere beim älteren Patienten muss das
Therapieziel die schnelle Mobilisierung durch eine adäquate Primärstabilität sein, um das
Komplikations-, Revisions- und Mortalitätsrisiko auf ein Minimum zu reduzieren.
Addenbrooke's cognitive examination III: diagnostic utility for detecting mild cognitive impairment and dementia in Parkinson's disease
Authors: Sousa Nariana Mattos Figueiredo , Brucki Sonia Maria Dozzi 
Published: March 2023

Abstract
Background Cognitive deficit in Parkinson disease (PD) is an important cause of functional disability in these patients and early detection, with sensitive instruments, can contribute to longitudinal monitoring.
Objective To investigate the diagnostic accuracy, sensitivity, and specificity of the Addenbrooke's Cognitive Examination-III in patients with PD, using the comprehensive neuropsychological battery as reference method.
Methods Cross-sectional, observational, case-control study. Setting: rehabilitation service. A total of 150 patients and 60 healthy controls matched for age, sex, and education. For level I assessment, Addenbrooke Cognitive Examination (ACE-III) was used. Level II assessment used a comprehensive neuropsychological battery of standardized tests for this population. All patients remained in on-state during the study. The diagnostic accuracy of the battery was investigated through the receiver operating characteristic (ROC) analysis.
Results The clinical group was divided into 3 subgroups: normal cognition in Parkinson's disease (NC-PD-16%), mild cognitive impairment due to Parkinson's disease (MCI-PD-69.33%), and dementia due to Parkinson's disease (D-PD-14.66%). ACE-III optimal cutoff scores for detecting MCI-PD and D-PD were 85/100 (sensitivity 58.65%, specificity 60%) and 81/100 points (sensitivity 77.27%, specificity 78.33%), respectively. Age was inversely associated with the performance of the scores (totals and domains of the ACE-III), while the level of education had a significantly positive correlation in the performance of these scores.
Conclusions ACE-III is a useful battery for assessing the cognitive domains and to differentiate individuals with MCI-PD and D-PD from healthy controls. Future research, in a community setting, is necessary to provide discriminatory capacity of ACE-III in the different severities of dementia.
Compartment Syndrome and Its Validation in Skeletal Injuries
Authors: Agrawal Prabhat , Girish M. , Ramanathan Ashok T. , Sudhakaran M. , Murali S.M. 
Published: March 2023

Background
Compartment syndrome, a potential limb-threatening condition in acute traumatic situations following different modalities of injury, may lead to irreversible damage or even life risk later. Its differential time-bound clinical presentation with added observer bias on available invasive and noninvasive diagnostic modalities influences the decision-making and undue delay for early intervention toward limb salvage procedure.

Results
Thirty-two patients were included in our study with mean age of 36; males (18; 56.3%) were more injured than females (14; 43.8%) and left limb (17; 53.1%) was more involved than right (15; 46.9%). Mean calf muscle measurement of total injured limb with relation to immediate time was 39.9 cm, after 1 hour was 40.69 cm, after 2 hours was 41.06 cm, and after 3 hours was 41.40 cm; 95% confidence interval was found to be statistically significant. Three patients (9%) underwent emergency decompression fasciotomy, with an average mean of 41.4 cm for injured limbs against 38.5 cm in control limb.

Conclusions
Compartment syndrome is an acute emergency with potential irreversible damage when undiagnosed. Bias on diagnosis evolves around observer skills and clinical invasive and noninvasive methods, with differential statistical results pertaining to its decision-making for emergency fasciotomy.
Society of Gastrointestinal Endoscopy of India Consensus Guidelines on Endoscopic Ultrasound-Guided Biliary Drainage: Part I (Indications, Outcomes, Comparative Evaluations, Training)
Authors: Rai Praveer , Udawat Priyanka , Chowdhary Sudipta Dhar , Gunjan Deepak , Samanta Jayanta , Bhatia Vikram , Singla Vikas , Mukewar Saurabh , Mehta Nilay , Achanta Chalapathi Rao , Dalal Ankit , Sahu Manoj Kumar , Balekuduru Avinash , Bale Abhijit , Basha Jahangir , Philip Mathew , Rana Surinder , Puri Rajesh , Lakhtakia Sundeep , Dhir Vinay ,   India EUS Club
Published: March 2023

AbstractEndoscopic management of bile duct obstruction is a key aspect in gastroenterology practice and has evolved since the first description of biliary cannulation by McCune et al in 1968. Over many decades, the techniques and accessories have been refined and currently, the first-line management for extrahepatic biliary obstruction is endoscopic retrograde cholangiopancreaticography (ERCP). However, even in expert hands the success rate of ERCP reaches up to 95%. In almost 4 to 16% cases, failure to cannulate the bile duct may necessitate other alternatives such as surgical bypass or more commonly percutaneous transhepatic biliary drainage (PTBD). While surgery is associated with high morbidity and mortality, PTBD has a very high reintervention and complication rate (∼80%) and poor quality of life. Almost parallelly, endoscopic ultrasound (EUS) has come a long way from a mere diagnostic tool to a substantial therapeutic option in various pancreatico-biliary diseases. Biliary drainage using EUS-guidance (EUS-BD) has gained momentum since the first report published by Giovannini et al in 2001. The concept of accessing the bile duct through a different route than the papilla, circumventing the shortcomings of PTBD and sometimes bypassing the actual obstruction have enthused a lot of interest in this novel strategy. The three key methods of EUS-BD entail transluminal, antegrade, and rendezvous approach. Over the past decade, with growing experience, EUS-BD has been found to be equivalent to ERCP or PTBD for malignant obstruction with better success rates.EUS-BD, albeit, is not devoid of adverse events and can carry fatal adverse events. However, neither the technique of EUS-BD, nor the accessories and stents for EUS-BD have been standardized.Additionally, different countries and regions have different availability of the accessories making generalizability a difficult task. Thus, technical aspects of this evolving therapy need to be outlined. For these reasons, the Society of Gastrointestinal Endoscopy India deemed it appropriate to develop technical consensus statements for performing safe and successful EUS-BD.
Sedation Vacation in Neurocritical Care: A Proposal Algorithm
Authors: Moscote-Salazar Luis Rafael , Florez-Perdomo William A. , Janjua Tariq 
Published: March 2023

AbstractDaily sedation interruption or sedation vacation is a strategy for neurological evaluation, respiratory mechanics, cardiac stability, and eventual weaning to extubation. However, its application has safety aspects such as pulmonary, cardiac, and neurological complications. A protocol-driven sedation vacation in the medical intensive care helps with the reduction in the intensive care length of stay and increase in ventilator-free days.1,2 The same approach can be used in neurointensive care with alterations based upon the neurocritical care progression.