bluuebunny/crossref_metadata_2025_split huggingface dataset:
Drosophila melanogaster as an alternative animal model in fat metabolism studies
Authors: de Silva Dilan , Gunatilake Mangala 
Published: January 2025

Abstract

Drosophila melanogaster is one of the most abundantly utilized model organisms today, in various contexts of biomedical research. It serves as one of the best alternative model organisms as it comprises most genes related to metabolism which are conserved in the human genome. The simplicity in genetics as well as their rapid life cycle makes it a righteous model organism that can be efficiently utilized in research. With the latest advances, numerous studies have disclosed the significance of using Drosophila as a model in studying fat metabolism and related diseases as well as potential therapeutic targets. It is discovered that Drosophila accommodates a range of cell types and organs which entail lipid metabolism and related energy homeostasis similar to those of mammals. Fat storage in Drosophila occurs in the form of lipid droplets carrying cholesterol and triacylglycerol which are accumulated primarily in the fat body – the analogous Drosophila organ to mammalian adipose tissue. Moreover, the Drosophila fat body has showcased its role in storage and metabolic regulation, akin to the function of the liver in mammals. Following a comprehensive overlook on Drosophila as a model organism in the study of fat metabolism, this narrative review covers lipid anabolic, enzymatic, and regulatory processes in Drosophila as well as the use of Drosophila in the study of fat metabolism associated diseases.
Evaluation of antibiotic utilization and prescription patterns in inpatient hospital setting: A retrospective observational study
Authors: Nyamagoud Sanatkumar Bharamu , Swamy Agadi Hiremath Viswanatha , Varghese Leena Elizabeth 
Published: January 2025

Abstract

Background:
Antibiotic prescribing patterns among inpatients significantly impact healthcare quality and antimicrobial stewardship. Understanding these patterns is essential for optimizing patient care and combating antimicrobial resistance.

Objective:
This retrospective observational study aimed to analyze antibiotic utilization and prescription practices among inpatients at Vivekananda General Hospital, Hubballi, over one year.

Materials and Methods:
Data were collected on 903 inpatients admitted across six departments. Demographic information, indications for antibiotic therapy, and prescribed antibiotics were recorded. Analysis included the frequency of antibiotic use, indications for therapy, types of antibiotics prescribed, and adherence to essential drug lists.

Results:
The study revealed a predominance of male patients (57.69%) and a majority admitted to the General Medicine department. Prophylactic antibiotic use was prevalent (43.72%), with indications including renal and respiratory diseases. Ceftriaxone emerged as the most commonly prescribed antibiotic (21.71%), followed by Piperacillin+Tazobactam (17.01%) and Metronidazole (12.76%). Adherence to essential drug lists was high (91.43%).

Conclusion:
This study underscores the importance of continuous monitoring of antibiotic prescribing practices in hospitals to optimize patient care and address the growing threat of antimicrobial resistance. Understanding prescribing patterns can inform targeted interventions aimed at promoting judicious antibiotic use and preserving the effectiveness of antibiotics for future generations.
Characteristics and outcomes of patients with repeat rapid response team activations in a tertiary centre in Singapore
Authors: Koh Siew Hui Michelle , Young Si Ling , Tan Qiao Li , Ng Lit Soo , Ko Joanna Phone , Teo Constance Wei-Shan , Chai Hui Zhong , Goh Ken Junyang 
Published: January 2025

Abstract

Introduction:
Rapid response teams (RRTs) are prevalent in healthcare institutions worldwide. Repeated activations are associated with increased morbidity and higher resource utilisation, and represent a heterogeneous population that may benefit from early identification. To date, there are no published data on repeat RRT activations in Singapore. We aimed to compare the characteristics and outcomes between patients who required single versus multiple RRT activations.

Methods:
We conducted a prospective cohort study of daytime RRT activations from February 2018 to June 2020 in Singapore General Hospital. Repeat activations were defined as patients who had two or more activations during their admission. Patient demographics, clinical characteristics, RRT interventions, patient disposition after activation and hospital length of stay were recorded. The primary outcome of interest was in-hospital mortality.

Results:
A total of 1055 patients were included, with 85 requiring repeat RRT activations. There was no significant difference in comorbidities and functional performance status at the time of first activation between patients with single versus repeated activations. Patients with repeat activations had more days in hospital before their index activation, a longer hospital length of stay and higher in-hospital mortality. Repeat activations had the strongest association with mortality on multivariate analysis.

Conclusion:
Our study found that repeat RRT activations were significantly associated with higher in-hospital mortality rates and increased hospital length of stay, independent of age, performance status and comorbidities. The results of our study highlight the need for early recognition and intervention in this patient group and discussion on goals of care when appropriate.
ПАРАТИРЕОИДНЫЙ ГОРМОН – ВАЖНЫЙ МАРКЕР НАРУШЕНИЙ КОСТНОГО МЕТАБОЛИЗМА МЕНОПАУЗАЛЬНОГО ПЕРИОДА. ЕГО РОЛЬ В ПРЕДОПЕРАЦИОННОЙ ПОДГОТОВКЕ
Authors: Разова Л.В. , Оболенский В.Н. 
Published: January 2025

Первичный гиперпаратиреоз (ПГПТ) – распространенное эндокринное заболевание с широким спектром нарушений, например таких, как остеопороз. Во многих случаях диагноз не устанавливается из-за бессимптомного течения, поэтому раннее выявление пациентов с ПГПТ имеет важное значение. Цель – выявить факторы риска нарушения костного метаболизма у женщин в менопаузальном периоде. Материал и методы. В исследование включены 135 амбулаторных пациенток в менопаузальном периоде (средний возраст – 52,39 ± 1,16 года). Проведен анализ гормонального фона: уровней фолликулостимулирующего гормона (ФСГ), лютеинизирующего гормона (ЛГ), паратиреоидного гормона (ПТГ). Результаты. Впервые результаты анализа соотношения ФСГ/ЛГ показали статистически значимую корреляцию с изменениями ПТГ, что важно при назначении лечения остеопении и остеопороза. На основании данных исследования можно перспективно использовать определение ФСГ/ЛГ для раннего выявления нарушений минерального обмена у женщин и мужчин в период перименопаузы, менопаузы и андропаузы. Заключение. В ходе хирургического протокола, а также на этапе предоперационной подготовки актуальна оценка риска нарушения костного обмена. ПТГ объективно можно считать одним из маркеров такого риска.
Primary hyperparathyroidism (PGPT) is a common endocrine disorder with a wide range of disorders, such as osteoporosis. Many women are not diagnosed due to an asymptomatic course. Therefore, early detection of patients with PHPT is important. Objective: to identify risk factors for impaired bone metabolism in menopausal women. Materials and methods. The study included 135 outpatient patients in the menopausal period (mean age of the subjects was 52.39 ± 1.16 years). The hormonal background was analyzed: follicle-stimulating hormone (FSH), luteinizing hormone (LH), parathyroid hormone (PTH). Results. For the first time, the results of the analysis of the FSH/LH ratio showed a statistically significant correlation with changes in PTH; this is important in prescribing the treatment of osteopenia and osteoporosis. Based on the data of the study, it is possible to promisingly use the determination of FSH/LH for the early detection of mineral metabolism disorders in women and men during perimenopause, menopause and andropause. Conclusion. During the surgical protocol, and at the stage of preoperative preparation, an assessment of the risks of bone metabolism will be relevant. PTH can objectively be considered one of the markers of such risk.
ЛОКАЛЬНЫЙ МИКРОБИОЛОГИЧЕСКИЙ МОНИТОРИНГ КАК ВЕКТОР ПРОФИЛАКТИКИ И ЛЕЧЕНИЯ ИНФЕКЦИЙ УРОГЕНИТАЛЬНОГО ТРАКТА
Authors: Верижникова Е.В. , Новичков Д.А. 
Published: January 2025

Проведен микробиологический мониторинг на возбудителей урогенитальных инфекций. Представляет огромный интерес взаимосвязь микрофлоры мочи и микробного содержания цервикального канала. Многочисленную нишу в микробиологической мозаике полового канала занимают Escherichia coli и Enterococcus sp., аналогичная тенденция характерна и для микробного состава мочи. Предложено решение проблемы по сдерживанию антибиотикорезистентности в виде протокола, составленного в соответствии с результатами локального мониторинга микробных паттернов мочи и отделяемого женских половых органов.
Microbiological monitoring for pathogens of urogenital infections was carried out. The relationship between the urine microflora and the microbial content of the cervical canal is of great interest. Escherichia coli and Enterococcus sp. occupy a large niche in the microbiological mosaic of the genital canal, a similar trend is typical for the microbial composition of urine. A solution to the problem of containing antibiotic resistance has been proposed in the form of a protocol in accordance with local monitoring of microbial patterns of urine and female genital discharge.
МУЛЬТИСИСТЕМНЫЙ ЭНДОМЕТРИОЗ: КЛИНИЧЕСКИЙ СЛУЧАЙ
Authors: Габидуллина Р.И. , Маметова Н.А. 
Published: January 2025

Эндометриоз – одна из наиболее серьезных проблем современной гинекологии. Эндометриоидные гетеротопии встречаются с частотой 5–10% среди женщин репродуктивного возраста. Цель. В данной статье представлен клинический случай мультисистемного эндометриоза у пациентки 31 года. Результаты. Пациентка, имеющая факторы риска развития эндометриоза, впервые оперирована хирургами по поводу пахового эндометриоза, подтвержденного патоморфологическим исследованием. В дальнейшем у пациентки выявлен кишечный эндометриоз со стенозом сигмовидной кишки, сочетанный с эндометриозом репродуктивных органов. В последующем наблюдался рецидив пахового и тазового эндометриоза. Заключение. Эндометриоз следует признать системным заболеванием. При выявлении очага эндометриоза следует провести планомерный поиск других локализаций для своевременного их выявления и лечения
Endometriosis is one of the most serious problems of modern gynecology. Endometrioid heterotopias occur with a frequency of 5–10% among women of reproductive age. Aim. This article presents a clinical case of multisystem endometriosis in a 31-year-old patient. Results. A patient with risk factors for endometriosis was operated on for the first time by surgeons for inguinal endometriosis, confirmed by a pathomorphological study. Subsequently, the patient was diagnosed with intestinal endometriosis with sigmoid colon stenosis combined with endometriosis of the reproductive organs. Subsequently, a recurrence of inguinal and pelvic endometriosis was observed. Conclusion. Endometriosis should be recognized as a systemic disease. When detecting a focus of endometriosis, a systematic search for other localizations should be carried out for their timely detection and treatment.
Análisis del uso de herramientas digitales en los estudiantes universitarios de profesorados del PADEP/D durante su formación académica
Authors: Girón Sánchez Iris María 
Published: January 2025

OBJETIVO: Analizar del uso de herramientas digitales en los estudiantes universitarios de profesorados del PADEP/D durante su formación académica. MÉTODO: Paradigma pospositivista, enfoque cuantitativo, con diseño no experimental de alcance correlacional de tipo transversal, muestreo probabilístico aleatorio simple, el análisis estadístico de las variables herramientas digitales y la motivación de los estudiantes en la formación académica, la muestra es de 67 estudiantes del Programa Académico de Desarrollo Profesional Docente, de la Escuela de Formación de Profesores de Enseñanza Media de la Universidad de San Carlos de Guatemala. RESULTADOS: Es relevante destacar resultados obtenidos a partir de ANOVA de la dimensión “herramientas digitales”, subdimensión “herramientas de interpretación de la información”. “herramientas de modelado dinámico de información” y “herramientas de comunicación” de acuerdo al uso de herramientas digitales las medias de los grupos varían entre 2.2 y 3.1, el valor p de .555 es mayor que .05, además, de la dimensión “motivación en la formación académica” con la subdimensión “motivación extrínseca” dio mayor variabilidad dentro de los grupos de 42.320 que entre ellos de 1.649, el valor p de .489 es mayor que .05, para ambas dimensiones no existen diferencias estadísticamente significativas entre los cuatro grupos de profesorados del PADEP/D. CONCLUSIÓN: En la era del conocimiento, la digitalización cada vez más se ha integrado a la enseñanza superior, por lo que posteriormente se pueden realizar estudios para ampliar conocimientos en relación a factores de acceso, actitud y percepción de las Tecnologías de la Información y Comunicación -TIC-.
Kewenangan Badan Penyelesaian Sengketa Konsumen dalam Mengadili Sengketa yang Bersumber pada Wanprestasi dalam Jual Beli
Authors: Sukamto Nur Suprianto , Sri Widiarty Wiwik , Fauzan Fauzan 
Published: January 2025

Penelitian bertujuan untuk menelaah kewenangan Badan Penyelesaian Sengketa Konsumen (BPSK) dalam mengadili perselisihan konsumen di Indonesia.Penelitian bertujuan guna memahami serta menganalisis otoritas BPSK dalam mengadili sengketa konsumen di Indonesia serta menguraikan implikasi dari putusan-putusan yang telah diambil. Dengan metode penelitian yuridis normatif, sehingga di dalam penelitian menganalisis hukum yang mengatur BPSK dan implikasi putusan yang diambil. Hasilnya diharapkan dapat memberikan kontribusi teoritis dalam hukum perdata, sementara praktisnya dapat menjadi masukan kebijakan bagi pemerintah. Penelitian ini mengungkap bahwa BPSK mempunyai peranan yang krusial dalam menyelesaikan sengketa, namun masih terdapat sejumlah masalah terkait eksistensi dan kewenangannya. Melalui kasus-kasus tertentu, penelitian ini menyoroti perlunya pemahaman yang lebih mendalam dari Majelis Hakim terhadap batasan kewenangan BPSK untuk memastikan keadilan untuk menyelesaikan perselisihan konsumen yang terjadi di Indonesia. Berdasarkan hasil temuan dapat ditarik kesimpulan bahwa otoritas BPSK saat mengadili sengketa konsumen di Indonesia sudah diatur secara normatif yang tercantum dalam Undang-Undang Perlindungan Konsumen, dengan mekanisme penyelesaian sengketanya diuraikan dalam peraturan-peraturan terkait.
Faktor-Faktor Sistem Admisi yang Berhubungan dengan Kepuasan Pasien yang Pertama Kali Dirawat di RSUD X
Authors: Norsehan Norsehan , Hamid Achir Yani S. , Anshari Muhammad 
Published: January 2025

In a service institution such as a hospital, there is a significant correlation between service and patient satisfaction, this is an important component as information in efforts to improve hospital services. The patient admission process is often considered the front-line experience in healthcare facilities. A positive first impression between staff and patient is important to ensure a positive patient experience. Patient acceptance standards starting from the registration of new patients need to pay attention to the factors of staff acceptance, reception methods, pleasant waiting rooms, effective waiting times and handing over of patients to the treatment room. The purpose of this study was to obtain an overview of the relationship between factors (reception staff, patient admissions, waiting room conditions, waiting time, and the handover process with patient satisfaction. The study design was descriptive correlational, with a cross sectional study approach, looking at the influence of the admission system on patient satisfaction.A total sample of 82 respondents, taken using purposive sampling technique. Through the process of identifying and calculating the results of the study, the majority of respondents were satisfied with the admission process, and there was a significant relationship between the admission process (acceptance of staff, method of admission, waiting room, waiting time, and handover) with patient satisfaction. The results of the analysis on all satisfaction dimensions (tangible, reliable, responsiveness, assurance, and empathy) have a value lower than the 0.05 significance level, indicating a strong relationship between the admission process and patient satisfaction. Thus, from the results of the study in this study, it was found that in all aspects which include: reception, reception method, waiting room, waiting time and patient acceptance have an effect on patient satisfaction.
Navigating Linguistic Challenges: The Use Of Balinese Terminologies By Tourism Actors In Rural Villages
Authors: Damayanti Luh Sri , Pratama I Wayan Adi , Wibawa I Ketut 
Published: January 2025

The massive growth of tourism villages in Bali is not echoed by the development of quality of the local community. One biggest challenge faced by local community in running the tourism was English competence. This research aimed at identifying the use of English in tourism villages and the challenges encountered by tourism actors in tourism villages in Bali. The research was qualitative research involving 19 informants. Data were obtained vi written interviews and analysed qualitatively. The results revealed that English is used to do general communication, sell tickets, do upselling, explain the villages, do correspondence, and handle complaints. In the communication, the tourism actors encountered 2 categories of barriers which were cultural barrier & language barrier. The cultural barrier was represented by the difficulty in explaining Balinese local terminologies and the difficulty to understand tourists’ utterances due to different accents. Meanwhile the language barrier wasclearly seen by the limited English vocabulary that they mastered.
Pengaruh Media Buku Suka Terhadap Suku Kata Pada Anak Usia 5-6 Tahun di TK Negeri Pembina 2 Kota Jambi
Authors: Khusnul Mar'iyyah Supriadi  , Nia Rismala  , Sherin Azzahra Ismi Melati  , Thalitha Ariandinie Julea  
Published: January 2025

Penelitian yang dilakukan peneliti di TK Negeri 2 Kota Jambi, menemukan adanya permasalahan pada rendahnya kemampuan membaca permulaan pada kelompok B usia 5-6 tahun. Untuk mengatasi permasalahan tersebut, peneliti mengembangkan alat pembelajaran yang diberi nama BUKU SUKA. Tujuan dari penelitian ini adalah untuk mengetahui seberapa besar pengaruh media BUKU SUKA terhadap membaca permulaan berfokus pada perkembangan suku kata untuk anak usia 5 - 6 tahun di TK Negeri Pembina 2 Kota Jambi. penelitian ini menggunakan metode eksperimental dengan pendekatan one group pretest posttest dengan sampel sebanyak 16 anak kelompok B kelas B4. Hasil penelitian menunjukkan peningkatan yang signifikan pada kemampuan perkembangan suku kata untuk anak usia 5 - 6 tahun.
Socio-Legal Aspects Related to Violence Against Women and the Family Group: A Review from the Optic of the SDG
Authors: Rengifo Viviana García 
Published: January 2025

Objective: to analyze the socio-legal aspects related to violence against women and the family group under the focus of SDGs 5 and 16 focused on gender equality, peace and justice.
Theoretical Framework: Violence against women is a serious problem in many countries; Sexual aggression is one of the most common forms of violence against women.

Method: It was guided by a qualitative approach with a systematic review design; The population and sample are comprised of 19 articles, which were extracted from the databases of SCOPUS, Scielo, DOAJ and others, requiring the entry of the descriptors "Violence against women, "violence" and "violence against the family group " and " Socio-legal aspects related to violence".

Results and Discussion: After the review and analysis of the articles were obtained as results that the social aspects, such as the consumption of substances and the economic situation, prevailed in the studied cases; Furthermore, the level of violence reached a high level, where the prevalent types of violence were psychological and physical.

Research Implications: Accordingly, it is concluded that aspects socio-legal issues related to violence against women and the family group must be recognized opportunely by the states with the purpose of working through policies, intervention plans, political strategies, etc.

Originality/Value: The innovative character of this study also lies in its proposal to consider on the ground the legal response to these phenomena, as well as the social aspects that aggravate or perpetuate them, thus promoting a more complete and holistic analysis of the problem. In order to highlight the need for a timely recognition of these aspects by the States, the investigation proposes a path towards the implementation of effective public policies that address violence from a socio-legal perspective, combining prevention, intervention and legal regulation strategies.
OPTIMALISASI DOSIS PENGGUNAAN PAC (Poly Aluminium Chloride) DALAM PROSES PENGOLAHAN AIR BERSIH DI PDAM TIRTA BANTIMURUNG MENGGUNAKAN METODE JARTEST
Authors: Arista Ayu , Andrie Andrie , Hakim Hakim 
Published: January 2025

Pengolahan air bersih pada proses koagulasi-flokulasi menggunakan. Untuk itu PDAM Bantimurung memiliki peran penting menjaga kualitas air bersih tetap terjaga standarnya. Tujuan dari penelitian ini untuk mengoptimalkan dosis optimum PAC menggunakan metode jar test, mengoptimalkan hasil analisa pada parameter suhu, pH, TDS dan Kekeruhan setelah penambahan PAC pada pagi dan siang hari dan mengetahui dosis optimum pada parameter suhu, ph, TDS dan Kekeruhan antara pagi dan siang hari. Hasil dari penelitian ini dosis optimum PAC pada uji Jar Test pagi dan siang hari yaitu 1000 mg/l, 2000 mg/l, 3000 mg/l, 4000 mg/l. Untuk pagi hari parameter suhu didapatkan nilai 26 ̊C dengan nilai efektivitas 3,70% pada dosis 2000 mg/l, parameter pH didapatkan nilai 8 dengan nilai efektivitas 3,61% pada dosis 4000 mg/l, parameter TDS didapatkan nilai 125 mg/l dengan nilai efektivitas 10,07% pada dosis 2000 mg/l dan parameter kekeruhan didapatkan nilai 3,56 NTU dengan nilai efektivitas 96,42% pada dosis 4000 mg/l. Untuk Siang hari parameter suhu didapatkan nilai 27,3 ̊C dengan nilai efektivitas 2,50% pada dosis 4000 mg/l, parameter pH didapatkan nilai 8 dengan nilai efektivitas 4,76% pada dosis 4000 mg/l, parameter TDS didapatkan nilai 143 mg/l dengan nilai efektivitas 7,74% pada dosis 2000 mg/l dan parameter kekeruhan didapatkan nilai 4,67 NTU dengan nilai efektivitas 95,76% pada dosis 4000 mg/l. Untuk dosis optimum parameter suhu yaitu 2000 mg/l, parameter TDS yaitu 2000 mg/l, parameter kekeruhan yaitu 4000 mg/l pada pengujian pagi hari dan parameter pH yaitu 4000 mg/l pada pengujian siang hari.