bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intravitreal fluocinolone acetonide 0.19 mg (ILUVIEN ® ) in patients with non-infectious uveitis: real-world effectiveness and safety outcomes at 12 months
Authors: Moll-Udina Aina , Hernanz Inés , Sainz-de-la-Maza Maite , Pelegrín Laura , Borges Ana Isabel Coelho , Pazos Marta , Adán Alfredo , Llorenç Victor 
Published: April 2023

Abstract
Purpose This assessed the effectiveness of the 0.19 mg fluocinolone acetonide (FAc) implant by multimodal measurements in patients with non-infectious uveitis (NIU) in a real-world setting in Spain.Methods A prospective study of patients who had NIU including uveitic macular oedema (UME) with ≥ 12 months follow-up was done. Exclusion criteria include infectious uveitis and uncontrolled glaucoma or ocular hypertension requiring more than 2 medications. Effectiveness was assessed using a multicomponent outcome measure that included nine outcomes, with effectiveness defined as all components being met at every timepoint. Secondary outcome measures: onset or progression of glaucoma and investigator-reported adverse events.Results Twenty-six eyes from 22 patients were included, with 96.2% having an indication including UME. During the 12-month study, the FAc implant was effective in 15 (57.7%) eyes, reaching effectiveness as soon as 2 weeks post-implantation. Mean best-corrected visual acuity and mean central macular thickness (CMT) were significantly improved vs. baseline at all timepoints (all comparisons p < 0.01). During the 12-month study, markers of inflammation (anterior chamber cells and vitreous haze) also significantly declined. Factors predicting effectiveness at month 12: systemic corticosteroid dose pre-FAc, higher immunomodulatory therapy (IMT) load at baseline and thicker retinal nerve fiber layer (RNFL) at baseline (all p < 0.05). Factors predicting failure: male, thinner RNFL at baseline and treatment ineffective at 1 month (all p < 0.05). In parallel, corticosteroid and IMT use also declined significantly. No significant increases in IOP.Conclusion The FAc implant is safe and effective at treating NIU over 12 months in a real-world setting in Spain.
Mesoporous fibrous Nanosilica (KCC-1) supported Polyaniline composite: Synthesis, characterization, and dye removal assessment in simulated and real water samples
Authors: TANWEER MOHD SAQUIB , IQBAL ZAFAR , ALAM MASOOD 
Published: April 2023

Abstract
In this work, polyaniline (PANI) functionalized fibrous porous silica nanoparticles (KCC-1 NPs) namely KCC-1/PANI nanocomposite with excellent surface area (391.34 m2/g) and adsorption capacities have been successfully developed by the hydrothermal method followed by the in situ polymerization technique. KCC-1/PANI has been characterized using FE-SEM, FTIR, XRD, TGA-DTA, BET, and Zeta potential analyses and their adsorption property has been screened out against several dyes. The morphological characterization shows wrinkle shaped, fibrous type KCC-1 NPs. According to the TGA results, KCC-1/PANI withstands the temperature upto 470 ℃ with weight loss of only 35%. The adsorption capacities of PANI, KCC-1 and KCC-1/PANI nanocomposite for CV uptake at neutral pH was evaluated. The qmax of KCC-1/PANI against CV adsorption was 456.62 mg/g (obtained from Langmuir model). Adsorption mechanism investigation disclosed that the sorption of CV dye onto KCC-1/PANI was ascribed because of π-π and electrostatic interactions, and hydrogen bonding (dipole-dipole interaction and Yoshida bonding) between hydrogen containing functional groups (hydroxyl and amine) of the KCC-1/PANI nanoadsorbent and CV molecules. Adsorption process strictly fulfilled pseudo second order kinetic model with R2 (0.998) and closeness between qecal (1428.57 mg/g) and qeexp (1417.14 mg/g). Thermodynamic studies revealed that the CV abatement using KCC-1/PANI is endothermic process with ΔH° = 9.11 kJ/mol and spontaneous as value of ΔG° is negative at all temperatures (ΔG° = -9.29 to -11.15 kJ/mol). Batch adsorption operations were also confirmed to validate the ability of the KCC1-/PANI nanoadsorbent to adsorb CV dye from real wastewater, including tap water, river water, and laundry wastewater. Hence, this study reflecting that KCC-1/PANI nanoadsorbent could be an exquisite material for the mitigation of cationic dye pollutants from aqueous environment.
METTL21C mediates the occurrence of autophagy and formation of slow-twitch muscle fibers after exercise
Authors: Qu Jing , Dang Shuai , Sun Yuan-Yuan , zhang Tao , Jiang Hai , Lu Hong-Zhao 
Published: April 2023

Abstract
Homeostasis is essential for muscle repair and regeneration after skeletal muscle exercise. This study investigated the role of methyltransferase-like 21C (METTL21C) in skeletal muscle of mice after exercise and the potential mechanism. First, muscle samples were collected at 2, 4, and 6 weeks after exercise, liver glycogen, muscle glycogen, blood lactic acid (BLA) and triglyceride (TG) were assessed. Moreover, the expression levels of autophagy markers and METTL21C in skeletal muscle were analyzed. The results showed that the expressions of METTL21C and MYH7 in the gastrocnemius muscle of mice in the exercise group were significantly higher than that in the control group after exercise, which suggested that long-term exercise promoted the formation of slow-twitch muscle fibers in mouse skeletal muscle. Likewise, the autophagy capacity is enhanced with the extension of exercise in muscles. The findings were further verified in mouse C2C12 cells. We discovered that knockdown of Mettl21c reduced the expression of MYH7 and autophagy level in mouse myoblasts. These findings indicate that METTL21C mediates autophagy in skeletal muscle after exercise, maintains skeletal muscle homeostasis, and promotes differentiation of myogenic and formation of slow muscle fiber.
Attractive targeted sugar bait: the pyrrole insecticide chlorfenapyr and the antimalarial pharmaceutical artemether-lumefantrine arrest Plasmodium falciparum development inside wild pyrethroid-resistant Anopheles gambiae s.s. mosquitoes
Authors: N’Guessan Raphael , Camara Soromane , Rowland Mark , Alou Ludovic P. Ahoua , Wolie Rosine Z. , Zoh Marius G. , N’Guessan Brou , Tia Innocent Z. , Oumbouke Welbeck A. , Thomas Matthew B. , Koffi Alphonsine A. 
Published: April 2023

Abstract
Background Attractive targeted sugar bait (ATSB) is a novel approach to vector control, offering an alternative mode of insecticide delivery via the alimentary canal, with potential to deliver a variety of compounds new to medical entomology and malaria control. Its potential to control mosquitoes was recently demonstrated in major field trials in Africa. The pyrrole chlorfenapyr is an insecticide new to malaria vector control, and through its unique mode of action – disruption of ATP mediated energy transfer in mitochondria – it may have direct action on energy transfer in the flight muscle cells of mosquitoes. It may also disrupt mitochondria of malarial parasites co-existing within the infected mosquito. However, little is known about the impact of such compounds on vector competence in mosquitoes responsible for malaria transmission.Method In this study, we compared the effect of ATSBs containing chlorfenapyr insecticide and, as a positive control, the antimalarial drugs artemether/lumefantrine (A/L) on Plasmodium falciparum development in wild pyrethroid-resistant Anopheles gambiae s.s. for their capacity to reduce vector competence. To do this, we exposed females mosquitoes to ATSB containing sublethal dose of chlorfenapyr (CFP: 0.025%) or concentrations of A/L ranging from 0.4/2.4 mg/ml to 2.4/14.4 mg/ml, either shortly before or after infective blood meals. The impact of their component compounds on the prevalence and intensity of P. falciparum infection were compared between treatments.Results We showed that both prevalence and intensity of infection were significantly reduced in mosquitoes exposed to either A/L or CFP, compared to unexposed negative control mosquitoes. The A/L dose (2.4/14.4 mg per ml) totally erased P. falciparum parasites: 0% prevalence of infection in female mosquitoes exposed compared to 62% of infection in negative controls (df = 1, χ2 = 31.23 p < 0.001). The dose of CFP (0.25%) that killed < 20% females in ATSB showed a reduction in oocyte density of 95% per midgut (0.18/3.43 per midgut).Conclusion These results are evidence that CFP, in addition to its direct killing effect on the vector, has the capacity to block Plasmodium transmission by interfering with oocyte development inside pyrethroid-resistant mosquitoes, and through this dual action may potentiate its impact under field conditions.
Chemical Diversity and In Vitro/In Silico Antiviral Activity of Extracts from Different Parts of Phyllanthus brasiliensis (Aubl.) Poir
Authors: Carvalho Alice Rhelly Veloso , Reis José Diogo Evangelista , Gomes Paulo Wender Portal , Ferraz Ariane Coelho , Mardegan Horrana Acácio , Menegatto Marília Bueno da Silva , Lima Rafaela Lameira Souza , de Sarges Maria Rosilda Valente , Pamplona Sônia das Graças Santa Rosa , Gontijo Karen Sartori Jeunon , de Magalhães José Carlos , Silva Milton Nascimento da , Magalhães Cintia Lopes de Brito , Silva Consuelo Yumiko Yoshioka e 
Published: April 2023

Abstract

Introduction: Plants of the genus Phyllanthus (Euphorbiaceae), the “stone breaker” has long been used in folk medicine to treat hepatitis B, an important viral disease. In this regard some species of this genus were tested against viruses as Herpes simplex virus type 1 (HSV-1), COVID and Hepatitis C virus (HCV), showing expressive inhibition in some of them, attracting attention to the genus and to its chemical constituents. Although P. brasiliensis has no traditional use as an antiviral plant, these findings urge us to consider whether P. brasiliensis, plant widely distributed in the Brazilian Amazon and its compounds have antiviral activity against Vero cell lines infected with Mayaro, Oropouche, Chikungunya, and Zika viruses.
Objectives: Thus, herein we describe a study of extracts' chemical diversity, antiviral activity, and specialized metabolites detected in different parts of the Phyllanthus brasiliensis (Aubl.) Poir.,
Methods: In this context, liquid chromatography-mass spectrometry is a crucial analytical method to reveal the identity of many drug candidates from extracts from medicinal plants used to treat diseases, including for instance infections by viruses.
Results: As result, 44 compounds were annotated by mass spectrometry-based molecular networking approach. Along, the extracts were tested against Vero cell lines infected with Mayaro, Oropouche, Chikungunya, and Zika viruses. Overall, the results revealed that this species is high in fatty acids, flavones, flavan-3-ols, and lignans. Among them, especially lignans are known to have promising antiviral properties. In this context, in vitro assays revealed potent antiviral activity against different viruses, especially lignan-rich extracts MEB (EC50 = 0.80 µg.mL− 1, SI = 377.59), MEL (EC50 = 0.84 µg.mL− 1, SI = 297.62), and HEL (EC50 = 1.36 µg.mL− 1, SI = 735.29) against Zika virus (ZIKV).
Conclusions: The potential of lignans was also supported by in silico antiviral prediction, and Tuberculatin (a lignan) stood out with high activity score and as a strong candidate from MEL extract. Therefore, authors believe that P. brasiliensis extracts contain metabolites that could be a new kick-off point with candidates for antiviral drug development, with lignans becoming a promising trend for further virology research.
Performance Evaluation and Participatory Variety Selection of Improved Highland Sorghum Varieties At West Hararghe Zone
Authors: Begna Temesgen , Gichile Hayilu 
Published: April 2023

Abstract
The ultimate purpose of a crop improvement program is to develop high yielding cultivars with desirable traits for farmers. However farmers in marginal areas still grow low-yielding, disease- and pest-prone sorghum land-races. In order to address the issues of farmers' selection criteria, an experiment was conducted at Hirna and Chiro with the objectives of evaluating adaptability and identifying farmers' preferred traits. During the 2019 main cropping season, a total of six sorghum varieties were evaluated using a randomized complete block design. Direct-matrix and pair-wise ranking algorithms were used to evaluate farmers at the flowering and maturity developmental stages. Grain yield, biomass, seed color, disease resistance, and seed size characteristics were given priority by farmers when evaluating and selecting their preferred varieties. At a 1% probability level, the combined analysis of variance results revealed the existence of highly significant genetic variation among varieties for all the traits under study. The maximum grain yield was obtained from Dibaba (11.375tha-1) and Jiru (10.175tha-1) varieties, which were also, identified as the superior improved sorghum varieties by field experiment and farmer visual observation. The correlation between grain yield and days to 50% flowering (0.91**), days to maturity (0.73**), and thousand seed weight (0.91**) was positive and highly significant. Based on the preferences of farmers as a whole, Dibaba and Jiru were ranked first and second and followed by Adelle, Chiro, and ETS2752 respectively. As a result, farmers' evaluations and the result of field experiments led to the choice of the varieties Dibaba and Jiru due to their superior performance compared to the other varieties. Dibaba and Jiru improved sorghum varieties were thus recommended for multiplication and distribution to farmers through both formal and informal seed systems as the experiment's result. In general, plant breeders and farmers' perspectives were combined to boost acceptance rates and make effective breeding programs for future improvement.
The Future is Now for Precision Genomic Addiction Medicine as a Frontline
Modality for Inducing “Dopamine Homeostasis” in Reward Deficiency
Syndrome (RDS)
Authors: Gilley Elizabeth D. , Bowirrat Abdalla , Gupta Ashim , Giordano John , Dennen Catherine A. , Braverman Eric , Badgaiyan Rajendra D. , McLaughlin Thomas , Baron David , Blum Kenneth 
Published: April 2023

Abstract:
In this genomic era of addiction medicine, ideal treatment planning begins with genetic
screening to determine neurogenetic antecedents of the Reward Deficiency Syndrome (RDS) phenotype.
Patients suffering from endotype addictions, both substance and behavioral, and other
mental health/comorbid disorders that share the neurobiological commonality of dopamine dysfunction,
are ideal candidates for RDS solutions that facilitate dopamine homeostasis, addressing
the cause, rather than symptoms. Our goal is to promote the interplay of molecular biology and
recovery as well as provide evidence linked to RDS and its scientific basis to primary care physicians
and others. This was an observational case study with a retrospective chart review in which
an RDS treatment plan that utilized Genetic Addiction Risk Severity (GARS) analysis to evaluate
neurogenetic challenges was used in order to develop appropriate short- and long-term pharmaceutical
and nutraceutical interventions. A Substance Use Disorder (SUD) treatment-resistant patient
was successfully treated utilizing the GARS test and RDS science. The RDS Solution Focused
Brief Therapy (RDS-SFBT) and the RDS Severity of Symptoms Scale (SOS) may provide clinicians
with a useful tool for establishing neurological balance and helping patients to achieve selfefficacy,
self-actualization, and prosperity.
Effects of Kefir Consumption on Cardiometabolic Risk Factors: A Systematic
Review and Meta-analysis of Randomized Controlled Trials
Authors: Yahyapoor Farveh , Haghighat Neda , Sohrabi Zahra , Asbaghi Omid , Bagherniya Mohammad , Jamialahmadi Tannaz , Sahebkar Amirhossein 
Published: April 2023

Background:
Fermentation of lactose in milk by bacteria and yeasts naturally present in
kefir grains produces a beverage that has been suggested to have cardiovascular benefits. This systematic
review and meta-analysis of randomized controlled trials (RCTs) aimed to evaluate the effects
of this kefir beverage on cardiometabolic risk factors.

Methods:
Literature search utilised PubMed, Scopus, ISI Web of Science, and Google Scholar for
articles published from inception until June 2021. Cardiometabolic risk indices extracted included
insulin and insulin resistance (HOMA_IR), total cholesterol (TC), triglyceride (TG), high-density
lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), fasting blood sugar
(FBS), haemoglobin A1c (HbA1c) and body weight (BW). In total, six RCTs (314 subjects) were
selected for the meta-analysis. Inverse-variance weighted mean difference (WMD) with a 95% confidence
interval (CI) was calculated for the mean changes in TC, TG, HDL-C, LDL-C, FBS,
HbA1c and BW compared to baseline. A random effects model was used to estimate the pooled
WMD.

Results:
Kefir intake significantly reduced fasting insulin (WMD: -3.69 micro-IU/mL,95% CI:
-6.30 to -1.07, p = 0.006, I2 = 0.0%) and HOMA-IR (WMD: -2.56, 95% CI: -3.82 to -1.30,
p<0.001, I2 = 19.4%). No effect on TC (p = 0.088), TG (p = 0.824), HDL-C (p = 0.491), LDL-C (p
= 0.910), FBS (p = 0.267), HbA1c (p = 0.339) or body weight (p = 0.439) were found for kefir
treatment.

Conclusion:
Kefir has a beneficial effect in decreasing insulin resistance; however, no effect was
seen on BW, FBS, HbA1C, and lipid profile.
The Impact of Enhanced Recovery after Surgery Protocol Implementation
on Postoperative Pain Management in the Era of Opioid Crisis: The Postchemotherapy
Open RPLND Experience
Authors: Dimitropoulos Konstantinos , Pisters Louis L. , Papandreou Christos N. , Daliani Danai , Karatzas Anastasios , Petsiti Argiro , Tassoudis Vassilios , Arnaoutoglou Eleni , Vlachostergios Panagiotis J. , Tzortzis Vassilios 
Published: April 2023

Aim:
Enhanced Recovery After Surgery (ERAS) protocols have been proven to optimize
postoperative outcomes; however, misuse of opioid analgesics can still hinder postoperative recovery
due to related side effects and potential complications.

Introduction:
To determine if the implementation of ERAS protocol in post-chemotherapy retroperitoneal
lymph node dissection (PC-RPLND) patients could help with reducing postoperative pain and
opioid use.

Methods:
case-control study of consecutive testicular cancer patients with indications for PCRLPND,
who were offered Conventional Post-operative Management (CPM) or ERAS protocol. Outcomes
of interest included Visual Analogue Scale (VAS)-assessed pain level at postoperative days 3,
7, and 30, and Morphine-Equivalent Doses (MEDs)/postoperative day. Intraoperative parameters and
postoperative complications were recorded. Parametric and non-parametric tests were used for statistical
analysis.

Results:
In total, 100 opioid-naïve PC-RPLND patients were studied. CPM and ERAS groups (36 and
64 patients, respectively) had similar demographic and baseline clinical characteristics). ERAS group
patients had significantly lower blood loss (p = 0.005), blood transfusion rate (p < 0.001), and duration
of the procedure (p < 0.001). Post-operative complications were comparable between groups.
Nausea and bowel disorders were numerically but not statistically more frequent in the CPM group.
ERAS patients had shorter mean hospital stay (5.3 ± 1.4 vs. 7.4 ± 1.6 days, p < 0.001), lower daily
MEDs (4.73 ± 2.63 vs. 7.04 ± 2.29, p < 0.001), and lower VAS scores on post-operative day 7 (3.89 ±
1.07 vs. 4.67 ± 1.17, p = 0.001). Post-operative pain was similar between groups on post-operative
days 3 and 30.

Conclusion:
Systematic implementation of ERAS protocol after PC-RPLND improves pain management, optimizes patient recovery, and prevents over-prescription of opioid analgesics.
Employing “Red Flags” to Fight the Most Neglected Diseases: Nitroaromatic
as Still Suitable Tools to Treat Human and Veterinary Parasitosis
Authors: Galasse Rando Daniela Gonçales , de Oliveira Costa Helena Gabrielle , Fernanda Heitor Thais , de Moraes Josué , Amorim Pavani Thais Fernanda 
Published: April 2023

Abstract:
Nitroaromatic compounds have been used for treating parasitic diseases since the 1960s. Pharmacological alternatives to treat them are under observation. However, for the most neglected diseases, such as those caused by worms and less known protozoans, nitro compounds are still among the drugs of choice, despite their well-known collateral effects. In this review, we describe the chemistry and the uses of the still most employed nitroaromatic compounds for treating parasi-tosis caused by worms or lesser-known protozoans. We also describe their application as veterinary drugs. The most accepted mechanism of action seems to be the same, leading to collateral effects. For this reason, a special session was dedicated to discussing toxicity, carcinogenicity, and muta-genesis, as well as the most acceptable aspects of the known structure-activity/toxicity relationships involving nitroaromatic compounds. It employed the SciFindern search tool from the American Chemical Society in the search for the most relevant bibliography within the field, exploring key-word expressions such as “NITRO COMPOUNDS” and “BIOLOGICAL ACTIVITY” (within Ab-stracts or Keywords) and concepts related to parasites, pharmacology and toxicology. The results were classified according to the chemical classes of nitro compounds, being the most relevant stud-ies regarding journal impact and interest of the described results chosen to be discussed. From the found literature, it is easy to notice that nitro compounds, especially the nitroaromatic ones, are still widely used in antiparasitic therapy, despite their toxicity. They also are the best starting point in the search for new active compounds.
Recent Advancement in Multicomponent Synthesis of Fused Coumarin
Derivatives
Authors: Yadav Vinita , Thakur Ajay , Bharti Ruchi , Verma Monika , Sharma Renu 
Published: April 2023

Abstract:
The synthesis of coumarin derivatives has been an essential topic since its discovery in 1820. In bioactive compounds, the coumarin moiety serves as a backbone, as many such bioactive compounds with the coumarin moiety play a significant role in their bioactivities. Given this moie-ty's relevance, several researchers are developing fused-coumarin derivatives to create new drugs. Mostly the approach done for this purpose was a multicomponent reaction based. Over the years, the multicomponent reaction has gained enormous popularity, and this approach has evolved as a replacement for conventional synthetic methods. Because of all these perspectives, we have report-ed the various fused-coumarin derivatives synthesized using multicomponent reactions in recent years.