bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long Biliopancreatic Limb Roux-En-Y Gastric Bypass Versus One-Anastomosis Gastric Bypass: a Randomized Controlled Study
Authors: Salman Mohamed AbdAlla , Abelsalam Ahmed , Nashed George Abdelfady , Yacoub Mohamed , Abdalla Ahmed 
Published: May 2023

Abstract
Background
Roux-en-Y gastric bypass (RYGB) is the gold standard in bariatric surgery. The one-anastomosis gastric bypass (OAGB) procedure, first introduced by Dr. Rutledge, has demonstrated a 25% greater weight loss efficiency than the traditional Roux-en-Y gastric bypass (RYGB) procedure due to the substantially longer biliopancreatic limb (BPL).

Aim of the study
The current work aimed to compare the outcomes of OAGB and long BPL RYGB regarding weight loss and comorbidity resolution.

Patients and methods
This randomized controlled trial was done at our institution between September 2019 and January 2021. Patients who were candidates for bariatric surgery were randomly and equally allocated to two groups. Group A underwent OAGB, while group B underwent long BPL RYGB. Patients were followed up for 6 months postoperatively.

Results
This study included 62 patients equally allocated to OAGB or long BPL RYGB, with no dropouts during follow-up. At 6 months, there was no statistically significant difference between the two groups regarding postoperative BMI (P = 0.313) and the EBWL (P = 0.238). There was comparable remission of diabetes mellitus (P = 0.708), hypertension (P = 0.999), OSA (P = 0.999), joint pain (P = 0.999), and low back pain (P = 0.999). Seven patients in the OAGB group experienced reflux symptoms (P = 0.011), which were managed by proton pump inhibitors.

Conclusion
Extending the BPL in RYGB provides weight loss and comorbidity remission comparable to that of OAGB. Some OAGB-related reflux cases remain a concern. However, they were sufficiently controlled with PPIs. Due to OAGB superior technical simplicity, long BPL RYGB should be preserved for cases whom are more risky for bile reflux.

Graphical Abstract
Numerical study on local short-term heat treatments for joining by forming of high-strength 7xxx aluminum
Authors: Wiesenmayer Sebastian , März Raphaela , Merklein Marion 
Published: May 2023

Abstract7xxx aluminum alloys have very high specific strengths, making them interesting for manufacturing car bodies. However, the limited formability of the precipitation hardenable alloys in the artificially aged T6 temper is challenging for forming and joining processes. The pre-conditioning of aluminum sheets by a short-term retrogression is a promising approach to enhance the process limits of joining by forming technologies. In addition, localizing the heat treatment enables the control of the material flow. However, for a targeted material flow, a deeper understanding of the relation between the heat treatment layout and its influence on joining processes is needed, which can be achieved with the aid of numerical analyses. Therefore, within the scope of this work, an approach for the numerical simulation of locally limited heat treatment layouts for the control of the material flow of high-strength aluminum sheets in joining by forming process is shown. The investigations are conducted for the simulation software LS-DYNA and the innovative shear-clinching process. Process models for the local retrogression heat treatment of punch-sided AA7075 T6 and the subsequent shear-clinching as well as an approach to couple the individual models are presented. By performing a localized retrogression from the T6 temper, the radial material displacement of the upper sheet in the shear-clinching process can be reduced in comparison to joining AA7075 in the W temper. The control of the material flow in the joining process thereby causes the improvement of geometric features, which are critical for the joint strength.
The Role of Defensins as Pollen and Food Allergens
Authors: Cosi Valentina , Gadermaier Gabriele 
Published: May 2023

Abstract

Purpose of Review
Defensin-polyproline–linked proteins are relevant allergens in Asteraceae pollen. Depending on their prevalence and amount in the pollen source, they are potent allergens, as shown for the major mugwort pollen allergen Art v 1. Only a few allergenic defensins have been identified in plant foods, such as peanut and celery. This review provides an overview of structural and immunological features, IgE cross-reactivity, and diagnostic and therapeutic options regarding allergenic defensins.

Recent Findings
We present and critically review the allergenic relevance of pollen and food defensins. The recently identified Api g 7 from celeriac and other allergens potentially involved in Artemisia pollen-related food allergies are discussed and related to clinical severity and allergen stability. To specify Artemisia pollen-related food allergies, we propose the term “defensin-related food allergies” to account for defensin-polyproline–linked protein-associated food syndromes.

Summary
There is increasing evidence that defensins are the causative molecules in several mugwort pollen-associated food allergies. A small number of studies have shown IgE cross-reactivity of Art v 1 with celeriac, horse chestnut, mango, and sunflower seed defensins, while the underlying allergenic molecule remains unknown in other mugwort pollen-associated food allergies. As these food allergies can cause severe allergic reactions, identification of allergenic food defensins and further clinical studies with larger patient cohorts are required. This will allow molecule-based allergy diagnosis and a better understanding of defensin-related food allergies to raise awareness of potentially severe food allergies due to primary sensitization to Artemisia pollen.
Role of miR-424 in the carcinogenesis
Authors: Ghafouri-Fard Soudeh , Askari Arian , Hussen Bashdar Mahmud , Taheri Mohammad , Akbari Dilmaghani Nader 
Published: May 2023

AbstractRecent studies have revealed the impact of microRNAs (miRNAs) in the carcinogenic process. miR-424 is a miRNA whose role in this process is being to be identified. Experiments in the ovarian cancer, cervical cancer, hepatocellular carcinoma, neuroblastoma, breast cancer, osteosarcoma, intrahepatic cholangiocarcinoma, prostate cancer, endometrial cancer, non-small cell lung cancer, hemangioma and gastric cancer have reported down-regulation of miR-424. On the other hand, this miRNA has been found to be up-regulated in melanoma, laryngeal and esophageal squamous cell carcinomas, glioma, multiple myeloma and thyroid cancer. Expression of this miRNA is regulated by methylation status of its promoter. Besides, LINC00641, CCAT2, PVT1, LIN00657, LINC00511 and NNT-AS1 are among lncRNAs that act as molecular sponges for miR-424, thus regulating its expression. Moreover, several members of SNHG family of lncRNAs have been found to regulate expression of miR-424. This miRNA is also involved in the regulation of E2F transcription factors. The current review aims at summarization of the role of miR-424 in the process of cancer evolution and its impact on clinical outcome of patients in order to find appropriate markers for malignancies.
A motivational model based on artificial biological functions for the intelligent decision-making of social robots
Authors: Maroto-Gómez Marcos , Malfaz María , Castro-González Álvaro , Salichs Miguel Ángel 
Published: May 2023

AbstractModelling the biology behind animal behaviour has attracted great interest in recent years. Nevertheless, neuroscience and artificial intelligence face the challenge of representing and emulating animal behaviour in robots. Consequently, this paper presents a biologically inspired motivational model to control the biological functions of autonomous robots that interact with and emulate human behaviour. The model is intended to produce fully autonomous, natural, and behaviour that can adapt to both familiar and unexpected situations in human–robot interactions. The primary contribution of this paper is to present novel methods for modelling the robot’s internal state to generate deliberative and reactive behaviour, how it perceives and evaluates the stimuli from the environment, and the role of emotional responses. Our architecture emulates essential animal biological functions such as neuroendocrine responses, circadian and ultradian rhythms, motivation, and affection, to generate biologically inspired behaviour in social robots. Neuroendocrinal substances control biological functions such as sleep, wakefulness, and emotion. Deficits in these processes regulate the robot’s motivational and affective states, significantly influencing the robot’s decision-making and, therefore, its behaviour. We evaluated the model by observing the long-term behaviour of the social robot Mini while interacting with people. The experiment assessed how the robot’s behaviour varied and evolved depending on its internal variables and external situations, adapting to different conditions. The outcomes show that an autonomous robot with appropriate decision-making can cope with its internal deficits and unexpected situations, controlling its sleep–wake cycle, social behaviour, affective states, and stress, when acting in human–robot interactions.
A Systems Biology Approach Reveals the Endocrine Disrupting Potential of Aflatoxin B1
Authors: Verga Jacopo U. , Padovano Costanzo , da Silveira Willian A. , Hazard E. Starr , Nugent Anne P. , Elliott Christopher T. , Carnevali Oliana , Galeazzi Roberta , Hardiman Gary 
Published: May 2023

AbstractBackgroundAflatoxin B1 (AFB1) a mycotoxin produced byAspergillus flavusandA. parasiticusis a potent carcinogen and causative agent of hepatocellular carcinoma (HCC). It is a food contaminant which presents a major risk to human health. AFB1 contamination poses a significant economic burden, as 25% of the world's food crops need to be destroyed annually. The mechanism of action (MOA) of aflatoxins remains to be fully elucidated. Recent findings suggest that AFB1 mediated endocrine disruption may occur in the population of regions with high contamination, even without evidence of direct dietary intake.ObjectiveAn integrative systems biology approach was undertaken to decipher the estrogenic component of the mechanism of action (MOA) of AFB1.MethodsMolecular Docking and Molecular dynamics simulations were performed to examine the binding affinity of AFB1 and its metabolite aflatoxin Q1 (AFQ1) with the Estrogen Receptors (ERs). Differential gene expression (DGE), gene ontology (GO) and pathway analyses were carried out on hepatic transcriptomic data generated from in vivo AFB1 exposures. In parallel exposures to the synthetic estrogen ethinylestradiol (EE2) were examined for overlapping effects. Finally, protein–protein interaction (PPI) network analysis assessed the involvement of estrogen responsive targets (ERTs) associated with aflatoxin exposure.ResultsThe free energies of binding affinity and estimated equilibrium dissociation constants (KD) demonstrated that AFB1 and AFQ1 can interact with the ERα and ERβ. DGE and GO analyses highlighted overlap in the responses between AFB1 and EE2 treatments with the activation of key processes involved in estrogenic signaling. PPI network analyses after AFBI exposure revealed a dynamic response to AFB1 treatments with the solid involvement of ERTs in regulatory networks.ConclusionsThis study revealed molecular interactions between aflatoxins (AFB1, AFQ1) and ERs in addition to overlap in differentially expressed genes and biological processes following AFB1 and EE2 exposures. The estrogenic components at the core of the PPI networks suggest that ER-mediated signaling pathways are a major component in the MOA of aflatoxins.
Long-Term Development of Training Characteristics and Performance-Determining Factors in Elite/International and World-Class Endurance Athletes: A Scoping Review
Authors: Staff Hanne C. , Solli Guro Strøm , Osborne John O. , Sandbakk Øyvind 
Published: May 2023

Abstract
Objective
In this scoping review, we aimed to 1) identify and evaluate existing research that describes the long-term development of training characteristics and performance-determining factors in male and female endurance athletes reaching an elite/international (Tier 4) or world-class level (Tier 5), 2) summarize the available evidence and 3) point out existing knowledge gaps and provide methodological guidelines for future research in this field.

Methods
This review was conducted following the Joanna Briggs Institute methodology for scoping reviews.

Results
Out of 16772 screened items across a 22-year period (1990-2022), a total of 17 peer-reviewed journal articles met the inclusion criteria and were considered for further analysis. These 17 studies described athletes from seven different sports and seven different countries, with 11 (69%) of the studies being published during the last decade. Of the 109 athletes included in this scoping review, one quarter were women (27%), and three quarters were men (73%). Ten studies included information about the long-term development of training volume and training intensity distribution. A non-linear, year-to-year increase in training volume was found for most athletes, resulting in a subsequent plateau. Furthermore, 11 studies described the development of performance determining factors. Here, most of the studies showed improvements in submaximal variables (e.g., lactate/anaerobic threshold and work economy/efficiency) and maximal performance-indices (e.g., peak speed/watt during performance testing). Conversely, the development of VO2max was inconsistent across studies. No evidence was found regarding possible sex differences in development of training or performance-determining factors among endurance athletes.

Conclusion
Overall, a low number of studies describing the long-term development of training and performance-determining factors is available. This suggests that existing talent development practices in endurance sports are built upon limited scientific evidence. Overall, there is an urgent need for additional long-term studies based on systematic monitoring of athletes from a young age utilizing high-precision, reproducible measurements of training and performance-determining factors.
Stabilising market expectations through a market tool: a proposal for an enhanced TPI
Authors: Amato Massimo , Belloni Everardo , Favero Carlo A. , Gobbi Lucio , Saraceno Francesco 
Published: May 2023

AbstractThis paper puts forward a proposal to complete the ECB Transmission Protection Instrument (TPI) with the aim of making it more effective in anchoring the yields of European sovereign debts to Member States’ fundamentals. We use a model in which yields fluctuate within bands, which we specify following two alternative approaches: stochastic and deterministic. The resulting fluctuation's interval represents the range of yields that can be seen as justified by Member States’ fundamentals; yields outside the band would instead trigger the ECB intervention as foreseen by the TPI. The proposal minimizes the risk of moral hazard, as the fluctuation bands vary as each country's creditworthiness changes. Moreover, the proposal is directly implementable with existing Treaties.
Students from humanities and human sciences are basically the same aren’t they? Cultural factors affecting entrepreneurship in Iran
Authors: Lee Kerry M. , Khoshnevisan Fatemeh , Sharifi Saeid 
Published: May 2023

AbstractIn a third-generation university, concepts of creativity, innovation and entrepreneurship, help link the university with industry and society. These concepts, however, have not been uniformly distributed across all university disciplines. This paper, reviews the characteristics of a third-generation university, focusing on the capabilities of the humanities faculties to address the challenges and barriers of entrepreneurship. Identification of these notions is important for the development of the humanities in academic entrepreneurship. This research was conducted among 80 Iranian humanities entrepreneurs, using the Hofstede Model of National Culture and Entrepreneurial Tendency and Action questionnaires as data collection tools. Entrepreneurial tendency among those in the human sciences disciplines was greater than those in the humanities. Short-term orientation was only influential in the humanities group. However, individualism–collectivism and short-term orientation were influential to entrepreneurial tendency in both disciplines. While the power distance (high) was influential to entrepreneurial tendency in the humanities. The findings of this study showed significant entrepreneurial tendency differences between students from the humanities and human sciences. The findings also show that entrepreneurial tendency in the humanities is mostly influenced by cultural factors. This research has provided invaluable knowledge of the entrepreneurial differences from a cultural perspective in the third-generation university.
Real interpolation of variable martingale Hardy spaces and BMO spaces
Authors: Lu Jianzhong , Weisz Ferenc , Zhou Dejian 
Published: May 2023

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“Comply, strategise, or resist?”: Exploring early-career women’s academic identities in Australian higher education using Foucauldian discourse analysis
Authors: Phillips Matthew J. , Dzidic Peta L. , Roberts Lynne D. , Castell Emily L. 
Published: May 2023

AbstractThe becoming of, and being, an early-career academic is a dynamic journey, marked by movement through learning, adapting, and adopting new skills and capacities, being ‘thrown in the deep end’ of academic responsibilities, and beginning to develop an academic identity. We explored how early-career women academics within Australian universities conceptualise their academic identities, and the subject positions (i.e., identities/ways of being) made available through their discourse. Seventeen participants were interviewed, aged between 27 and 62 years, with transcripts of interviews analyzed using Foucauldian Discourse Analysis. Three subject positions were identified—The Compliant Woman (who follows the rules and meets the expectations of the institution); The Strategic Woman (who balances complying and safely challenging the traditional academic ways of being); and The Rebellious Woman (who outrightly challenges the conditions of academia). Discourse surrounding compliance, tolerance, obedience, the patriarchy, and survival, created subjectivities suggesting that the early-career women academics felt unsafe and insecure in academia, as well as having to work harder to prove themselves in a setting that works to exclude them. The key message was that no matter their approach, the early-career women academics felt damned in their navigation of academia.
Recurrent Continuous Adversarial Balancing for Estimating Individual Treatment Effect Over Time
Authors: Zhu Peifei , Li Zisheng , Ogino Masahiro 
Published: May 2023

AbstractEstimating individual treatment effects (ITE) from observational data have become an important topic in various fields. In healthcare, determining the optimal time and amount of the treatment is crucial for improving each patient’s quality of life. However, existing methods mainly focused on estimating treatment effect under static setting with categorical treatments. In this work, we proposed Recurrent Continuous Adversarial Balancing (RCAB), a method that incorporates adversarial learning into a sequence-to-sequence recurrent network to reduce selection bias in dynamic data. Moreover, we reformulated imbalance loss to be appropriate for continuous scenario. RCAB is empirically validated in both synthetic and real-world datasets. The results demonstrate that RCAB outperforms various state-of-the-art methods, and it is applicable to time-series data with any types of treatments.
Global, Regional, and National Trends in Incidence and Mortality of Primary Liver Cancer and Its Underlying Etiologies from 1990 to 2019: Results from the Global Burden of Disease Study 2019
Authors: Cao Guiying , Liu Jue , Liu Min 
Published: May 2023

Abstract
Objective
Primary liver cancer is not only one of the most common causes of cancer deaths but also the second most common cause of premature death worldwide. Understanding the trends in incidence and mortality of primary liver cancer and its etiologies is crucial for development of effective prevention and mitigation strategies. This study aimed to quantify the trends in incidence and mortality of primary liver cancer and its etiologies at the global, regional and national levels using data from Global Burden of Disease (GBD) study.

Method
Annual incident cases, deaths, age-standardized incidence rates (ASIRs), and age-standardized mortality rates (ASMRs) of primary liver cancer and its etiologies, including hepatitis B, hepatitis C, alcohol use, nonalcoholic steatohepatitis, and other causes, between 1990 and 2019 were collected from GBD study 2019. Percentage changes in incident cases and deaths and estimated annual percentage changes (EAPCs) in ASIRs and ASMRs of primary liver cancer and its etiologies were calculated to quantify their temporal trends. Correlations of EAPC in ASIRs and ASMRs with socio-demographic index (SDI) and universal health coverage index (UHCI) in 2019 were separately evaluated by Pearson correlation analyses.

Results
Globally, the incident cases and deaths of primary liver cancer increased by 43.11% from 373 393 in 1990 to 534 365 in 2019 and 32.68% from 365 213 in 1990 to 484 584 in 2019, respectively. ASIR and ASMR of primary liver cancer decreased by an average of 2.23% (95% CI 1.83%, 2.63%) and 1.93% (95% CI 1.55%, 2.31%) per year between 1990 and 2019 worldwide, respectively. ASIRs and ASMRs of primary liver cancer varied between regions, with an increasing trend in ASIR (EAPC = 0.91; 95% CI 0.47, 1.35) and a stable trend in ASMR (EAPC = 0.42, 95% CI − 0.01, 0.85) of primary liver cancer in high SDI region between 1990 and 2019. Nearly half (91/204) of the countries suffered an increasing trend in ASIR of primary liver cancer and more than one-third (71/204) of the countries suffered an increasing trend in ASIRs of primary liver cancer from all etiologies between 1990 and 2019 worldwide. Positive correlations of EAPC in ASIR and ASMR of primary liver cancer with SDI and UHCI were observed in nations with SDI ≥ 0.7 or UHCI ≥ 70.

Conclusion
Primary liver cancer remains a major public health concern globally, with an increasing trend in the numbers of incident cases and deaths in the past three decades. We observed an increasing trend in ASIR of primary liver cancer in nearly half of the countries and an increasing trend in ASIRs of primary liver cancer by etiology in more than one-third of the countries worldwide. In line with the Sustainable Development Goals, the identification and elimination of risk factors for primary liver cancer will be required to achieve a sustained reduction in liver cancer burden.