bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long-term multicenter comparison shows equivalent efficacy of monoclonal antibodies in severe asthma therapy
Authors: Kayser Moritz Z. , Suhling Hendrik , Fuge Jan , Hinze Christopher A. , Drick Nora , Kneidinger Nikolaus , Behr Jürgen , Taube Christian , Welte Tobias , Haasler Ina , Milger Katrin 
Published: August 2023

Abstract
Background
Monoclonal antibodies (biologics) drastically changed severe asthma therapy. Mepolizumab (anti-interleukin (IL) 5), benralizumab (anti-IL5 receptor alpha), and dupilumab (anti-IL4/13) are the most used biologics in this context. While all biologics are efficient individually, the choice of biologic is complicated by insufficient data on their comparative long-term treatment efficacy. Here, we compare the real-life efficacy of these biologics in asthma therapy over 12 months.
Methods
280 severe asthma patients treated with mepolizumab (129/280, 46%), benralizumab (83/280, 30%) or dupilumab (68/280, 24%) for one year were analyzed retrospectively. Data were collected at baseline and after 6 and 12 months of therapy. Endpoints were changes pulmonary function (PF), exacerbation rate, oral corticosteroid (OCS) use and dose, asthma control test (ACT) score and fractional exhaled nitric oxide (FeNO) levels as well as responder status measured by the recently published “Biologic Asthma Response Score” (BARS).
Results
All biologics led to significant improvements in PF, ACT and OCS dose. Only Mepolizumab and Benralizumab significantly decreased the exacerbation rate, while only Mepolizumab and Dupilumab significantly decreased FeNO. Responder rates measured by BARS were high across all groups: roughly half of all patients achieved full response and most of the remainder achieved at least partial responder status. Overall, outcomes were similar between groups after both 6 and 12 months.
Conclusions
All biologics showed great efficacy in individual parameters and high responder rates measured by BARS without a clinically relevant advantage for any antibody. Response was usually achieved after 6 months and retained at 12 months, emphasizing the utility of early response assessment.
Evaluating pooled testing for asymptomatic screening of healthcare workers in hospitals
Authors: Heath Bethany , Evans Stephanie , Robertson David S. , Robotham Julie V. , Villar Sofía S. , Presanis Anne M. 
Published: August 2023

Abstract
Background: There is evidence that during the COVID pandemic, a number of patient and HCW infections were nosocomial. Various measures were put in place to try to reduce these infections including developing asymptomatic PCR (polymerase chain reaction) testing schemes for healthcare workers. Regularly testing all healthcare workers requires many tests while reducing this number by only testing some healthcare workers can result in undetected cases. An efficient way to test as many individuals as possible with a limited testing capacity is to consider pooling multiple samples to be analysed with a single test (known as pooled testing).
Methods: Two different pooled testing schemes for the asymptomatic testing are evaluated using an individual-based model representing the transmission of SARS-CoV-2 in a 'typical’ English hospital. We adapt the modelling to reflect two scenarios: a) a retrospective look at earlier SARS-CoV-2 variants under lockdown or social restrictions, and b) transitioning back to 'normal life' without lockdown and with the omicron variant. The two pooled testing schemes analysed differ in the population that is eligible for testing. In the 'ward’ testing scheme only healthcare workers who work on a single ward are eligible and in the 'full’ testing scheme all healthcare workers are eligible including those that move across wards. Both pooled schemes are compared against the baseline scheme which tests only symptomatic healthcare workers.
Results: Including a pooled asymptomatic testing scheme is found to have a modest (albeit statistically significant) effect, reducing the total number of nosocomial healthcare worker infections by about 2% in both the lockdown and non-lockdown setting. However, this reduction must be balanced with the increase in cost and healthcare worker isolations. Both ward and full testing reduce HCW infections similarly but the cost for ward testing is much less. We also consider the use of lateral flow devices (LFDs) for follow-up testing. Considering LFDs reduces cost and time but LFDs have a different error profile to PCR tests.
Conclusions: Whether a PCR-only or PCR and LFD ward testing scheme is chosen depends on the metrics of most interest to policy makers, the virus prevalence and whether there is a lockdown.
Identification of necroptosis-related genes and immune infiltration analysis on the pathogenesis of recurrent implantation failure through integrated bioinformatics analysis
Authors: Xing Xiuye , Ni Xiaoxiao , Wang Jiaojiao , Shi Junmei 
Published: August 2023

Abstract
Purpose
This study aimed to elucidate the role of necroptosis, a cell death process, in the pathogenesis of Recurrent Implantation Failure (RIF), a significant hurdle in Assisted Reproductive Technology.
Methods
Using the Gene Expression Omnibus database, we isolated RIF-related RNA-seq data and identified differentially expressed necroptosis-related genes (DENRGs). Functional enrichment analysis, Protein-Protein Interaction (PPI) networks, transcription factors (TFs) regulatory network, and Single sample gene set enrichment analysis (ssGSEA) were employed to understand the role of these genes in RIF.
Results
Twenty DENRGs were filtered, and six key genes (MLKL, FASLG, XIAP, CASP1, BIRC3, and TLR3) were identified at the hub of the PPI network. A predictive model for RIF, based on these genes, displayed good performance. A positive correlation of TLR3 with PER2, RORC, and FOXO1, and a negative correlation with UHRF1, BRCA2, and GLI1 was observed in the TFs network. The RIF group demonstrated significantly lower infiltration levels of 16 immune cells. Expression levels of key genes, except for XIAP, differed significantly between RIF and control groups. Potential therapeutic drugs modulating CASP1 were also predicted.
Conclusion
The investigation highlights the crucial role of necroptosis-related genes, especially MLKL, FASLG, XIAP, CASP1, BIRC3, and TLR3 in RIF pathogenesis. The identified genes can contribute to an effective RIF predictive model and suggest potential therapeutic targets for novel RIF treatments.
The Efficacy and Safety of Perioperative Glucocorticoid for Total Knee Arthroplasty: A Systematic Review and Meta-analysis
Authors: Liu Fangyan , Duan Mei , Fu Huiqun , Wang Tianlong 
Published: August 2023

Abstract
Background: An increasing number of individuals undergo total knee arthroplasty (TKA), which can result in pain, limited motor function and adverse complications such as inflammation and poor rehabilitation. Glucocorticoids have been shown anti-inflammatory and antiemetic effects, but the drugs can also elevate blood glucose levels and increase the risk of wound infection. Thus, it is essential to investigate the efficacy and safety of glucocorticoid usage in TKA.
Method: A comprehensive systematic search of PubMed, Medline, EMBASE, Cochrane databases, to identify relevant randomized controlled trials (RCTs) of glucocorticoid application in TKA. The primary outcomes assessed were the postoperative pain assessment. Secondary outcomes included the range of motion in knee joint, levels of inflammatory cytokines, adverse complications, and the length of hospital stay.
Results: Thirty-six randomized controlled trials were included in the final analysis. The glucocorticoid group exhibited significant reduction in VAS scores on postoperative days 1, 2 (POD1, 2)and postoperative 3 months (POM3), as well as decreased morphine consumption on POD1 and increased range of motion (ROM) in knee joint on POD1, 3. Additionally, the glucocorticoid group exhibited decreased levels of postoperative inflammatory cytokines and the incidence of PONV along with a shorter length of hospital stay. The blood glucose on POD2 and occurrence of adverse complications were similar between two groups. The periarticular injection analgesia (PIA) group demonstrated lower VAS scores on POD2 and higher plasma CRP levels comparing to the systemic administration group.
Conclusion: Glucocorticoid application in TKA can provide anti-inflammatory, analgesic and antiemetic effects, as well as improved range of motion and rehabilitation. Moreover, periarticular injection of glucocorticoids can effectively alleviate pain, while systemic administration can decrease plasma CRP levels after TKA more significantly.
Health conditions in spousal caregivers of people with dementia and their relationships with stress, caregiving experiences, and social networks: longitudinal findings from the IDEAL programme
Authors: Sabatini Serena , Martyr Anthony , Hunt Anna , Gamble Laura D. , Matthews Fiona E. , Thom Jeanette M. , Jones Roy W. , Allan Louise , Knapp Martin , Quinn Catherine , Victor Christina , Pentecost Claire , Rusted Jennifer M. , Morris Robin G. , Clare Linda 
Published: August 2023

Abstract
Objectives: Evidence documenting health conditions in spousal caregivers of people with dementia is scarce. This study explores 1) type and number of health conditions among caregivers of people with dementia and subgroups based on age, sex, and education; 2) whether number of health conditions changed over two years; and 3) whether over time the number of health conditions was associated with stress, positive experiences of caring, and social networks.
Methods: Longitudinal data from the IDEAL (Improving the experience of Dementia and Enhancing Active Life) cohort were used. Participants comprised spousal caregivers (n= 977) of people with dementia taking part in IDEAL. Caregivers self-reported health conditions using the Charlson Comorbidity Index. Stress, positive experiences of caregiving, and social network were assessed over two years. Mixed effect models were used.
Results: On average participants had 1.5 health conditions at baseline; increasing to 2.1 conditions over two years. At baseline, caregivers aged <70 years were likely to have fewer health conditions than those aged 70-74 years. Those with a university education had fewer health conditions than those without educational qualifications. More health conditions were associated with greater stress at baseline but not with stress over time. Health conditions were not associated with sex, positive experiences of caregiving, or social network at any timepoint.
Discussion: For caregivers taking part in IDEAL caregiving was slightly more stressful for those in poorer health compared to those in better health. Findings highlight the importance of acknowledging that most caregivers have their own health problems which require management.
The effect of the plasminogen activator inhibitor-1 4G/5G polymorphism on the Venous thromboembolism risk after total knee arthroplasty
Authors: Xu Zhan , Xu Duliang , Wen Qingyu , Liu Yanbin , Yin Han 
Published: August 2023

Abstract
Background
We herein determine the relationship between 4G/5G polymorphism of the plasminogen activator inhibitor-1 (PAI-1) gene and Venous thromboembolism (VTE) after total knee arthroplasty (TKA); and identify independent risk factors associated with deep vein thrombosis (DVT) after TKA through multivariate regression analysis.
Methods
From August of 2022 to November of 2022, 100 participants who underwent primary knee arthroplasty were enrolled in the study. Venous whole blood samples were collected to determine PAI-1 4G/5G genotypes. Lower extremity venous ultrasound was performed to detect DVT on the 5th day postoperatively or when patients had symptoms of DVT. Univariate analyses were performed using the chi-square test. Variables with a P value of less than 0.10 on univariate analysis were entered into multivariate analysis. reported risk factors (Sex, age, operating time, disease, hemostatic drugs, laterality, D-dimer, anticoagulants) for DVT after knee arthroplasty, although the difference was not significant in our study, were also entered into multivariate analysis. Multivariate analysis was performed using a logistic proportional hazards regression model.
Results
The incidence of DVT in this study was 52%. There was no significant difference in gender proportion between the DVT group and the non-DVT group. The DVT group had reduced intraoperative blood loss (98.0 ml) than the non-DVT group (134.2 ml), although the difference was not statistically significant. The value of D-dimer in DVT group (0.27) was lower than that in the non-DVT group (0.69), but the difference was not significant. On univariate analysis, the 4G/5G genotype of PAI-1 gene was more represented in DVT group, as compared to the non- DVT group. Sex, age, operating time, disease, hemostatic drugs, laterality, D-dimer, anticoagulants have also been considered predictors of DVT in many studies; therefore, we also included these items in our multivariate analysis. On multivariate analysis, the 4G/5G genotype of PAI-1 gene was identified as independent prognostic factors for DVT after TKA.
Conclusions
When anticoagulants were used after total knee arthroplasty, the incidence of deep vein thrombosis was 52%. The 4G/5G genotype of PAI-1 gene may be a high-risk factor for DVT in patients undergoing TKA.
Knowledge and Attitude towards Monkeypox: Systematic review and meta-analysis
Authors: León-Figueroa Darwin A. , Barboza Joshuan J. , Siddiq Abdelmonem , Sah Ranjit , Valladares-Garrido Mario J. , Rodriguez-Morales Alfonso J. 
Published: August 2023

Abstract
Background
The increase in monkeypox (Mpox) incidence underscores the crucial need to understand and effectively address prevention, early detection, and agile response to this disease. Therefore, the present study aims to determine the knowledge and attitude towards Mpox.
Methods
A systematic review and comprehensive literature meta-analysis were conducted using prominent databases such as PubMed, Scopus, Web of Science, Embase, and ScienceDirect, with an updated search until June 25, 2023. The quality of the included cross-sectional studies was assessed using the Joanna Briggs Institute's Statistical Meta-Analysis Review Instrument. The collected data were recorded in a Microsoft Excel spreadsheet, and analyses were conducted using R software version 4.2.3. Additionally, Cochran's Q statistics were applied to assess the heterogeneity of the included studies.
Results
A total of 299 articles were retrieved from 5 databases. This study included 27 cross-sectional articles with a total sample of 22,327 participants, of which 57.13% were women. The studies were conducted in 15 countries through an online survey. All studies had a high level of quality. The combined prevalence of a good level of knowledge about Mpox was 33% (95% CI: 22%-45%; I2 = 100%), and the combined prevalence of a positive attitude towards Mpox was 40% (95% CI: 19%-62%; I2 = 99%). Additionally, as a secondary outcome, the combined prevalence of the intention to vaccinate against Mpox was 58% (95% CI: 37%-78%; I2 = 99%).
Conclusion
Good knowledge and a positive attitude towards Mpox were found to be low. The findings of this study highlight the need to identify gaps and focus on implementing educational programs on Mpox.
Terms used
Joanna Briggs Institute Meta-Analysis of Statistics Assessment and Review Instrument (JBI-MAStARI), Prospective International Registry of Systematic Reviews (PROSPERO), and Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA)
Influence of microbiota awareness in first trimester on high risk pregnancy in Turkish women: cross-sectional study
Authors: Cömert Tuğba Küçükkasap , Karadeniz Sinan , Akpınar Funda 
Published: August 2023

Abstract

Background:It is suggested that pregnancy risks may be related to microbial dysbiosis, and it is known that knowledge on this subject is reflected in behaviors. The aim of this study was to investigate whether microbiota awareness in the first trimester of pregnancy is associated with pregnancy-related risks.Methods:Within the scope of the study, the microbiota awareness scale was administered to 426 individuals in the first trimester of pregnancy, and information on any diagnosis related to high-risk pregnancy, gestational age, birth weight, and birth height of the newborn was obtained from their file records.Results:The mean total microbiota awareness score of individuals was 61.38±11.00 (26.00-91.00). The microbiota awareness score (56.85±11.65) was found to be lower in individuals diagnosed with high-risk pregnancy (p<0.05) than in healthy subjects (63.64±9.94). Moreover, in individuals with high-risk pregnancies, a positive correlation was found between the microbiota awareness score and newborn birth weight and height (p<0.05).Conclusion:The microbiota awareness level in pregnant women is associated with high-risk pregnancy and neonatal growth status.
Multi-Factor based Nutrition Management System and Recipe Recommendation Engine
Authors: Chaudhari Shilpa , R. Aparna , Ramesh Aravind Shreyas , Bhat Dheeraj , Gaurav V , Divya . 
Published: August 2023

Abstract
Nutrient management in the context of this research aims to quantize the consumption of essential nutrients in an efficient format such that it leads to a healthy and balanced lifestyle. Increased consciousness towards one’s health has recently been in the limelight which creates the need for an intelligent system specially customized for the individual that can analyze your consumption’s quality and suggest options that could essentially fulfill your body’s need to lead a healthy lifestyle. Existing literature uses few solution to recommend healthy recipe, which either lacks usage of authorized nutritional database or the required factors of user. This paper discusses an intelligent recipe recommender to aid in the development of a diet that allows all users to make healthy choices in their daily lives while still enjoying food and keeping healthy. The recipe recommender system is implemented as a mobile or web application that helps users who have nutritional deficiencies to maintain a healthy well-balanced diet by suggesting various recipes to the users in video format with additional relevant information which will improve the user’s well-being and quality of life.
Prognostic impact of primary tumor site on liver metastasis in resectable colorectal cancer
Authors: 郭 辉龙 , Chen Jingyao , Tang Youzhen , zeng Qian-Lin , Li Ming-Zhe , He Yulong , Wu Wen-Hui 
Published: August 2023

AbstractPurpose Currently, right colon cancer (RCC), left colon cancer (LCC), and rectal cancer (REC) are typically considered as different tumor entities when discussed. The curative effect and different prognoses of patients with colorectal liver metastases (CRLM) whom underwent simultaneous radical surgery are studied based on the site of the primary tumor. Methods This study analyzed 215 patients with CRLM at the First Affiliated Hospital of Sun Yat-sen University and were treated with radical surgery from 2008 to 2021. All data were analyzed by SPSS. Results Ratio of right colon liver metastasis (RCLM) of longitudinal diameter of primary tumor ≥ 5cm was more than left colon liver metastasis (LCLM) and rectal cancer liver metastasis (ReCLM) (61.0% versus 34.3% versus 33.3%, p = 0.001), and similarly for Percentage circumference of intestinal wall involved=1 (74.6% versus 57.8% versus 50.0%, p = 0.021).The three-year overall survival (OS) of RCLM group was significantly less than LCLM group and ReCLM group (37.5% versus 64.7% versus 62.5%, p = 0.016). The univariate and Multivariate analysis showed Percentage circumference of intestinal wall involved, lymph node metastasis and CA199 were the independent risk factors for OS of RCLM, and Percentage circumference of intestinal wall involved and CA199 were the independent risk factors for DFS of CRLM. Conclusion Primary tumors should be considered when analyzing the outcomes of CRLM.
Early detection of liver injuries by the Serum enhanced binding test sensitive to albumin post-transcriptional modifications
Authors: Balkhi Souleiman El , Rahali Mohamad Ali , Lakis Roy , Sauvage François Ludovic , Martin Marving , Janaszkiewicz Angelika , Lawson Roland , Goncalves Ruben , Carrier Paul , Loustaud-Ratti Veronique , Guyot Anne , Marquet Pierre , Meo Florent Di , Saint-Marcoux Franck 
Published: August 2023

Abstract
Background: Early and sensitive biomarkers of liver dysfunction and drug-induced liver injury (DILI) are still needed, both for patient care and drug development.
Methods: We developed the Serum Enhanced Binding (SEB) test to reveal post-transcriptional modifications (PTMs) of human serum albumin resulting from hepatocyte dysfunctions and further evaluated its performance in an animal model. The SEB test consists in spiking serum ex-vivo with ligands having specific binding sites related to the most relevant albumin PTMs and measuring their unbound fraction. To explore the hypothesis that albumin PTMs occur early during liver injury and can also be detected by the SEB test, we induced hepatotoxicity in male albino Wistar rats by administering high daily doses of ethanol and CCl4 over several days. Blood was collected for characterization and quantification of albumin isoforms by high-resolution mass spectrometry, for classical biochemical analyses as well as to apply SEB test.
Results: In the exposed rats, the appearance of albumin isoforms paralleled the positivity of the SEB test ligands and histological injuries. These were observed as early as D3 in the Ethanol and CCl4 groups, whereas the classical liver tests (ALT, AST, PAL) significantly increased only at D7. The behavior of several ligands were supported by structural and molecular simulation analysis.
Conclusion: The SEB test and albumin isoforms revealed hepatocyte damage early, before the current biochemical biomarkers. The SEB test should be easier to implement in the clinics than albumin isoform profiling.
Fear of depression recurrence among individuals with remitted depression: A qualitative interview study
Authors: Gumuchian Stephanie T. , Boyle Ariel , Hazel Lori H. , Ellenbogen Mark A. 
Published: August 2023

Abstract
Background
Major Depressive Disorder (MDD) is a prevalent psychiatric condition and the largest contributor to disability worldwide. MDD is highly recurrent, yet little is known about the mechanisms that occur following a Major Depressive Episode (MDE) and underlie recurrence. We explored the concept of fear of depression recurrence (FoDR) and its impact on daily functioning among individuals in remission from MDD.
Methods
30 participants (83% female; 37% White; Mage = 27.7, SD = 8.96) underwent semi-structured qualitative interviews. The interviews explored participants' experiences of FoDR including the frequency, severity, content, triggers, and impact of fears and associated coping strategies. We used content analysis to analyze the transcriptions.
Results
Most participants (73%) reported having FoDR, with varying frequency, severity, and duration of fears. The triggers and content of participants’ fears often mirrored the symptoms (e.g., low mood, anhedonia) and consequences (e.g., job loss, social withdrawal) endured during past MDEs. Some participants reported a minimal impact of FoDR on daily functioning, whereas others reported a positive (e.g., personal growth) or negative (e.g., increased anxiety) influence.
Limitations:
Our sample size did not allow for explorations of differences in FoDR across unique MDD subtypes or sociocultural factors.
Conclusions
The concept of FoDR may present a window into understanding the unique cognitive and behavioural changes that occur following MDD remission and underlie depression recurrence. Future research should emphasize the development of a FoDR measure so that associations between FoDR and recurrence risk, depressive symptoms, and other indices of functioning can be determined.