bluuebunny/crossref_metadata_2025_split huggingface dataset:
Menciptakan Keunggulan Bersaing pada Perguruan Tinggi Swasta (PTS) Melalui Keunikan Sumber Daya: Kajian Empiris Kebijakan Merdeka Belajar Kampus Merdeka (MBKM)
Authors: Gunarto Muji , Mawardah Mutia 
Published: June 2023

Kebijakan Merdeka Belajar Kampus Merdeka (MBKM) mendorong perguruan tinggi untuk meningkatkan kolaborasi. Tujuan penelitian ini adalah untuk mengkaji dampak keunikan sumber daya untuk menciptakan keunggulan bersaing Perguruan Tinggi Swasta di Kota Palembang. Metode penelitian dilakukan dengan pendekatan kuantitatif melalui survei terhadap 104 responden pada beberapa PTS di Kota Palembang. Teknik sampling yang digunakan secara stratified random sampling. Teknik analisis data dilakukan dengan pendekatan model persamaan struktural (SEM) dengan bantuan program LISREL. Hasil penelitian menunjukkan bahwa keunikan sumber daya berpengaruh signifikan terhadap kolaborasi, dan kolaborasi berpenagruh terhadap keunggulan bersaing perguruan tinggi. Semakin unik sumber daya yang dimiliki PTS maka akan membuka peluang meningkatnya kolaborasi dan pada ahirnya mampu menciptakan keunggulan bersaing PTS. Namun keunggulan bersaing tidak berpengaruh signifikan secara langsung terhadap keunggulan bersaing, artinya bahwa kolaborasi menjadi variabel intervening yang baik bagu keunikan sumber daya terhadap keunggulan bersaing PTS.
Рulmonary sarcoidosis in HIV-infected patients
Authors: Nikolaieva О.D. , Gumeniuk G.L. 
Published: June 2023

OBJECTIVE. To determine the clinical, X-ray examination features in the newly detected sarcoidosis in HIV-infected patients.
MATERIALS AND METHODS. HIV-infected patients (6 women, 10 men, middle age – 43.5, range – 25-62 years) with the newly detected sarcoidosis had been observed during 2006-2022 years. The level of CD4+ cells, signs or symptoms of disease, dependence of development of sarcoidosis on the terms of setting of antiretroviral therapy were considered. The following criteria were evaluated during X-ray examination and computer tomography (CТ): lymphadenopathy, pulmonary knots, focal consolidations, reticular or grainy changes, symptom of ground glass, cysts or fibrosis.
RESULTS AND DISCUSSION. A middle interval between two diagnoses was 1 year. A level of CD4+ cells was 424/µl (range – 34-680 cells/µl). All patients had pulmonary signs or symptoms at diagnosis giving of sarcoidosis. X-ray examination showed a lymphadenopathy, pulmonary knots, focal consolidations, reticular changes, symptom of ground glass, cysts. CТ showed a lymphadenopathy, knots, bulge of intersegments partitions, focal consolidations, reticular dimnesses, symptom of ground glass and cysts. All patients received a course of treatment based on corticosteroids. The result of the treatment was assessed as positive. No relapses of the disease were found.
CONCLUSIONS. The X-ray and clinical features in the newly detected pulmonary sarcoidosis in HIV-infected patients are analogical to those in patients without HIV-infection. A level of CD4+ cells in most patients was >200/µl. Development of sarcoidosis depends from conservation or updating of level of CD4+ of lymph cells, and mostly it exceeds 200 cells/µl. A treatment with corticosteroids promotes recovery.
Endocrine pathologies in the conditions of chemotherapy
Authors: Garnytska A.V. , Orlyk O.S. 
Published: June 2023

BACKGROUND. Cancer is the leading cause of death in the world. Chemotherapy is the most effective and in some cases the only method of treating oncopathology. At the same time, chemotherapy can lead to a number of side effects, among which endocrine disorders are noted.
OBJECTIVE. To investigate possible diseases of the endocrine system that develop during chemotherapy.
MATERIALS AND METHODS. A review of literary sources.
RESULTS AND DISCUSSION. In general, the statistics on the development of endocrine diseases during chemotherapy is limited and requires additional research to obtain a more accurate picture. Nevertheless, based on the data of the studied literature, it can be assumed that some of the patients who received chemotherapy developed the following endocrine disorders: hypothyroidism, Hashimoto’s thyroiditis, adrenal dysfunction (hyper- and hypocorticism), hypergonadotropic hypogonadism, diabetes mellitus.
CONCLUSIONS. Endocrine diseases that develop as a result of chemotherapy can significantly worsen the patient’s quality of life, and given the fact that chemotherapy is vital and in some cases the only treatment for oncopathology, doctors should timely monitor carbohydrate metabolism, thyroid function and other markers of endocrine diseases. No less important are preventive measures, including rational nutrition and physical activity, the intensity of exercises and movements for wellbeing.
Justification of the choice of hormone therapy for ovarian cancer
Authors: Mikhanovskyi A.A. , Kharchenko Yu.V. 
Published: June 2023

BACKGROUND. Hormonal dependence of ovarian cancer remains a debatable issue in modern oncogynecology. Its decision will allow not only to clarify the pathogenesis of the development of ovarian cancer, its prognosis, but also to substantiate the indications for hormone therapy as a component of complex treatment.
OBJECTIVE. To study the experience of domestic and foreign specialists regarding the pathogenetic rationale for prescribing hormone therapy to patients with ovarian cancer and its effectiveness.
MATERIALS AND METHODS. Generalization and analysis of scientific publications on the research topic.
RESULTS. The article summarizes data on the pathogenetic rationale for the appointment of hormone therapy, as well as the effectiveness of antiestrogens and aromatase inhibitors in the treatment of primary ovarian cancer and recurrences of the disease.
CONCLUSIONS. To date, indications for the appointment and criteria for the use of hormone therapy in the complex treatment of ovarian cancer are not developed. The question of the reliability of the factors of the disease prognosis, taking into account the hormonal receptor status of ovarian cancer, remains open.
Transferencia de precios en los mercados agrícolas de Ambato y Riobamba
Authors: Argothy Anderson , Martinez Juan Pablo , Carvajal Maria Belén , Morales Ximena 
Published: June 2023

INTRODUCCIÓN: La transmisión de precios en el mercado agrícola es un campo de estudio importante dentro de los mercados agrícolas, permite analizar la formación de precios y el comportamiento de los consumidores. OBJETIVO. Este trabajo tiene como objetivo principal validar la presencia de transmisión de precios en el mercado de la papa de las provincias de Tungurahua y Chimborazo. MÉTODO. El trabajo utiliza un modelo de Vectores Autorregresivos, utilizando información oficial del Ministerio de Agricultura y Ganadería para el período enero 2013 – abril 2020, lo que representa un total de 88 observaciones. RESULTADOS. Se evidencia la existencia de causalidad, además se comprueba la presencia de una transmisión de precios activa, adicionalmente se aprecia relación a largo plazo entre los mercados de las provincias de Tungurahua y Chimborazo. DISCUSIÓN Y CONCLUSIONES. La cercanía geográfica y la historia comercial de las dos provincias provoca una relación constante haciendo que el precio de un producto, en este caso la papa, se traslade de un mercado a otro casi de manera inmediata, adicionalmente vale mencionar que la relación es principalmente unidireccional.
A Clinical-Based Drug Interaction Alert (CIDIA) System for Preventing Drug Interaction and Its Associated Factors at Rural Primary Care Centres
Authors: Sari Flori R , Anwar Saiful , Risahmawati - , Fadhilah Marita , Ekayanti Fika 
Published: June 2023

Objectives: Drug-drug interaction (DDI) occurs following the prescription of more than one drug. DDI and its associated factors in Indonesia’s country’s primary care have not been reported.
Materials and Methods: Through this descriptive cross-sectional study, we analysed the DDI incidence using the Clinical-Based Drug Interaction Alert (CIDIA) alert system. Purposive research was carried out by analysing prescriptions (n=2410) from nine primary health cares.
Results: CIDIA alert system detected 7.5% DDI incidence in all prescriptions, categorized as mild (63%), moderate (36%) and serious (1%). Significant DDI incidence was observed in female patients (p<0.01), in patients older than 18 years (p<0.01) and in patients receiving three or more drugs (p<0.01). The most frequent incidence of DDI from each category was paracetamol-domperidone; dexamethasone-mefenamic acid and captopril-allopurinol.
Conclusion: CIDIA alert system has been shown to provide beneficial support in detecting DDI incidence. Careful consideration should be addressed particularly towards female patients, older patients, and patients receiving three or more drugs in preventing DDI incidence.
Bangladesh Journal of Medical Science Vol. 22 No. 03 July’23 Page : 667-675
One Anastomosis Gastric Bypass Surgery: Consequences Over Ascorbic Acid, Cobalamin, Calciferol, and Calcium
Authors: Singh Arya , Ahmad Rahnuma , Sinha Susmita , Haq Md Ahsanul , Narwaria Mahendra , Haque Mainul , Kumar Santosh , Sanghani Nandita 
Published: June 2023

Background: Nutrient deficiency after malabsorptive bariatric procedure is a common phenomenon. The study aims to determine the prevalence of nutritional insufficiencies (specific with Ascorbic acid, Cobalamin, calciferol and calcium) in obese population opting for One Ananstomosis Gastric Bypass surgery (OAGB), and also to understand the association of these nutrients with change in Body Mass Index (BMI) after the surgery.
Methods: One hundred fifty subjects comprising males and females aged 20-60 years were randomly selected at a bariatric center in India. Subjects belonged to both grade III and grade II obesity. Plasma aa, serum vitB12, serum VitD3 and serum calcium concentrations were prospectively assessed at 0m, 3m, and 6m of surgery through high-performance liquid chromatography.
Result: The values of nutrients beyond the standard levels are considered as deficiency. Both follow up values showed a significant increase in cobalamin, Calciferol, and ascorbic acid levels compared to baseline data.
Conclusion: Nutrition depletion and deficiency are often seen in post bariatric cases. The contributing factors included high BMI, food intolerance, and non-adherence to supplements and correct dietary regimens. With the correction of weight and comorbidities, the levels also showed a stable and positive level.
Bangladesh Journal of Medical Science Vol. 22 No. 03 July’23 Page : 695-708
The re-discovery in Sumatra of a rarely seen moth, Heterosphecia tawonoides, and its identification using citizen science platform iNaturalist.
Authors: Molyneaux Andrea 
Published: June 2023

Traditional methods of species identification involve collection and killing of specimens. The associated costs and expertise required are prohibitory. In this paper we describe the first documented record of Heterosphecia tawonoides in its natural habitat in Sumatra since 1887, reporting its identification using photographs uploaded to citizen science platform iNaturalist. Our findings add valuable information to the small body of work on this species and demonstrate the importance of having freely available high quality tools such as iNaturalist without which this important record would not have been reported and the observation of this rarely seen moth species in Sumatra would have remained unknown.
Analysis of Ship Seaworthiness Factors, Health and Safety Culture, Oversight of Port Authority and Harbor Authority Offices on Shipping Safety
Authors: Ignatius Martan  , Pius Memo Gading Agum Gumelar  , Andar Sri Sumantri  
Published: June 2023

Shipping safety is still a problem faced by sea transportation. Empirical data collected in this study shows the number of transportation accidents and fatalities shows a fluctuating number. This means that shipping safety is still a problem faced by the marine transportation industry in Indonesia. To answer this problem, this research is aimed at knowing the effect of ship's seaworthiness, ship health and safety culture, and supervision of the Harbormaster Office and Port Authority on shipping safety performance which is carried out empirically. Every sailing ship must be in a seaworthy condition so as to ensure safety and security while the ship is sailing. Ship's seaworthiness is also assisted with shipping safety facilities and infrastructure. Occupational health is a state of physical, mental and social well-being that allows every worker to work in a healthy manner with optimal productivity without endangering himself, his family, society and the surrounding environment. Occupational health efforts are efforts to harmonize work capacity, workload and work environment so that every worker can work healthily without endangering himself or the surrounding community, in order to obtain optimal work productivity. The duties and responsibilities of a porter are very important in providing a ship's seaworthiness certificate, sailing permit, safety and security as well as all sea transportation shipping activities in Indonesian waters.
Based on the results of research and multiple analysis, the following equations are produced:
Y = 1.957 + 0.762 X1 + 0.531 X2 + 0.244 X3 +
shows that, Based on empirical data (the results of filling out the questionnaire) and the results of multiple linear regression, it shows that the Shipworthiness variable (X1) has a value t count (10.260) > t table (1.99045) then, H0 is rejected and Ha is accepted. The Health and Safety Culture Variable (X2) has a t count (2.382) > t table (1.99045), so H0 is rejected and Ha is accepted. The Port Authority and Port Authority Supervision Variable (X3) has a value of t count (2.280) > t table (1.99045), then H0 is rejected and Ha is accepted. Thus, the results of the study show that there is a positive and significant influence between Shipworthiness, Health and Safety Culture, Harbormaster Supervision and Port Authority on Shipping Safety
Biomechanical comparison of all-on-4 and all-on-5 implant-supported prostheses with alteration of anterior-posterior spread: a three-dimensional finite element analysis
Authors: Sun Xin , Cheng Kangjie , Liu Yunfeng , Ke Sipeng , Zhang Wentao , Wang Linhong , Yang Fan 
Published: June 2023

Introduction: The all-on-4 concept is widely used in clinical practice. However, the biomechanical changes following the alteration of anterior-posterior (AP) spread in all-on-4 implant-supported prostheses have not been extensively studied.Methods: Three-dimensional finite element analysis was used to compare the biomechanical behavior of all-on-4 and all-on-5 implant-supported prostheses with a change in anterior-posterior (AP) spread. A three-dimensional finite element analysis was performed on a geometrical mandible model containing 4 or 5 implants. Four different implant configurations were modeled by varying the angle of inclination of the distal implants (0°and 30°), including all-on-4a, all-on-4b, all-on-5a, and all-on-5b, and a 100 N force was successively applied to the anterior and unilateral posterior teeth to observe and analyze the differences in the biomechanical behavior of each model under the static influence at different position.Results: Adding an anterior implant to the dental arch according to the all-on-4 concept with a distal 30° tilt angle implant exhibited the best biomechanical behavior. However, when the distal implant was implanted axially, there was no significant difference between the all-on-4 and all-on-5 groups.Discussion: In the all-on-5 group, increasing the AP spread with tilted terminal implants showed better biomechanical behavior. It can be concluded that placing an additional implant in the midline of the atrophic edentulous mandible and increasing the AP spread might be beneficial in improving the biomechanical behavior of tilted distal implants.
Lower limb joint loading in patients with unilateral hip osteoarthritis during bipedal stance and the effect of total hip replacement
Authors: van Drongelen S. , Holder J. , Stief F. 
Published: June 2023

Osteoarthritis of the hip is a common condition that affects older adults. Total hip replacement is the end-stage treatment to relief pain and improve joint function. Little is known about the mechanical load distribution during the activity of bipedal stance, which is an important daily activity for older adults who need to rest more frequently. This study investigated the distribution of the hip and knee joint moments during bipedal stance in patients with unilateral hip osteoarthritis and how the distribution changed 1 year after total hip replacement. Kinematic and kinetic data from bipedal stance were recorded. External hip and knee adduction moments were calculated and load distribution over both limbs was calculated using the symmetry angle. Preoperatively, the non-affected limb carried 10% more body weight than the affected limb when standing on two legs. Moreover, the mean external hip and knee adduction moments of the non-affected limb were increased compared to the affected limb. At follow-up no significant differences were observed between the patients’ limbs. Preoperative and postoperative changes in hip adduction moment were mainly explained by the combination of the vertical ground reaction force and the hip adduction angle. Stance width also explained changes in the hip and knee adduction moments of the affected leg. Furthermore, as with walking, bipedal standing also showed an asymmetric mechanical load distribution in patients with unilateral hip osteoarthritis. Overall, the findings suggest the need for preventive therapy concepts that focus not only on walking but also on optimizing stance towards a balanced load distribution of both legs.
High-throughput optical sensing of peri-cellular oxygen in cardiac cells: system characterization, calibration, and testing
Authors: Li Weizhen , McLeod David , Ketzenberger John T. , Kowalik Grant , Russo Rebekah , Li Zhenyu , Kay Matthew W. , Entcheva Emilia 
Published: June 2023

Human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) represent a scalable experimental model relevant to human physiology. Oxygen consumption of hiPSC-CMs has not been studied in high-throughput (HT) format plates used in pre-clinical studies. Here, we provide comprehensive characterization and validation of a system for HT long-term optical measurements of peri-cellular oxygen in cardiac syncytia (human iPSC-CM and human cardiac fibroblasts), grown in glass-bottom 96-well plates. Laser-cut oxygen sensors having a ruthenium dye and an oxygen-insensitive reference dye were used. Ratiometric measurements (409 nm excitation) reflected dynamic changes in oxygen, as validated with simultaneous Clark electrode measurements. Emission ratios (653 nm vs. 510 nm) were calibrated for percent oxygen using two-point calibration. Time-dependent changes in the Stern-Volmer parameter, ksv, were observed during the initial 40–90 min of incubation, likely temperature-related. Effects of pH on oxygen measurements were negligible in the pH range of 4–8, with a small ratio reduction for pH &gt; 10. Time-dependent calibration was implemented, and light exposure time was optimized (0.6–0.8 s) for oxygen measurements inside an incubator. Peri-cellular oxygen dropped to levels &lt;5% within 3–10 h for densely-plated hiPSC-CMs in glass-bottom 96-well plates. After the initial oxygen decrease, samples either settled to low steady-state or exhibited intermittent peri-cellular oxygen dynamics. Cardiac fibroblasts showed slower oxygen depletion and higher steady-state levels without oscillations, compared to hiPSC-CMs. Overall, the system has great utility for long-term HT monitoring of peri-cellular oxygen dynamics in vitro for tracking cellular oxygen consumption, metabolic perturbations, and characterization of the maturation of hiPSC-CMs.
Chemical stability of active ingredients in diluted veterinary disinfectant solutions under simulated storage conditions
Authors: Rhee Chae Hong , Lee Hye-sook , Yun Hyeong-jun , Lee Ga-Hee , Kim Su-Jeong , Song Sok , Lee Myoung-Heon , Her Moon , Jeong Wooseog 
Published: June 2023

Introduction: The product labels of veterinary disinfectants specify their expiration dates to prevent the use of outdated products, as these may result in disinfection and biosecurity failures during outbreak situations. However, a clear standard for the storage conditions of diluted disinfectant solutions has not yet been established, and the effects of storage conditions have scarcely been investigated. To fill this research gap, our study examined the stability of the active ingredients of diluted veterinary disinfectants based on their change in concentrations when stored at various temperatures for various time periods.Methods: Twenty veterinary disinfectants effective against either foot-and-mouth disease or avian influenza viruses were selected. The disinfectants were diluted to effective concentrations following the manufacturer’s instructions. Using selective analytical techniques, the concentrations of the active ingredients of the samples that had been stored for varying intervals at different temperatures (4, 20, 30, and 45°C) were determined. These samples included soaps and detergents, acids, oxidizing agents, aldehydes, and copper compounds. The active ingredient concentrations of two of the samples were determined following freezing/thawing cycle, to establish their stability when exposed to simulated winter conditions.Results: Our results showed that most of the active ingredients had concentrations of 90% or greater of their initial concentrations, indicating ≥90% stability over a 21-day period under the experimental storage conditions. However, there were some exceptions. Glutaraldehyde, formaldehyde, and malic acid are over 90% stable at ≤ 30°C for 21 days, but their concentrations decreased to below 90% of their initial concentrations at 45°C, indicating a decline in stability when stored at 45°C for 21 days. The concentrations of potassium peroxymonosulfate and peracetic acid rapidly declined with increasing time and temperature to less than 90% of their initial concentrations.Discussion: Based on our findings, we propose that diluted disinfectant solutions should preferably be prepared daily. However, if the daily preparation of a diluted disinfectant solution is not feasible, then our results can be used as a reference, providing basic scientific data on the chemical stability of diluted disinfectant solutions commonly used in the veterinary field, thus indicating suitable storage conditions.