bluuebunny/crossref_metadata_2025_split huggingface dataset:
Simultaneous Measurement of Calciprotein Particles with Different Assays and Clinical Outcomes in CKD
Authors: Tiong Mark K. , Holt Stephen G. , Ford Martin L. , Smith Edward R. 
Published: January 2025

Background:
Mineral metabolism abnormalities are an almost universal feature of chronic kidney disease (CKD) and are thought to contribute to the development of many adverse events. Calciprotein particles (CPP) form spontaneously in biological fluids from calcium and phosphate together with the glycoprotein fetuin-A. While CPP formation is a part of normal mineral homeostasis, levels are chronically elevated in CKD. Several assays have been developed to measure serum CPP, each linking high CPP levels to adverse clinical outcomes in CKD. However, direct comparisons among these assays are lacking. This exploratory study aims to compare these assays to assess their association with CKD progression and mortality.

Methods:
We measured baseline CPP levels using various methods on stored serum samples from 189 participants in a prospective observational cohort study of CKD stage 3/4 patients. Three assays were used to measure CPP: (1) ELISA (Fetuin-A CPP), (2) low-density (L-CPP) and high-density CPP (H-CPP) via gel filtration, and (3) primary (CPP-I) and secondary CPP (CPP-II) via flow cytometry. We examined the association of each CPP measure with all-cause mortality and CKD progression using unadjusted and covariate-adjusted Cox proportional hazard regression models.

Results:
In fully adjusted models, H-CPP (hazard ratio [HR] 1.53, 95% confidence interval [CI] 1.05 – 2.23, p=0.028) and CPP-II (HR 3.11, 95% CI 1.97 – 4.98, p<0.001) were significantly associated with an increased risk of all-cause mortality. Additionally, L-CPP (HR 1.91, 95% CI 1.43 – 2.62, p<0.001), CPP-I (HR 1.31, 95% CI 1.04 – 1.65, p=0.023), and CPP-II (HR 1.66, 95% CI 1.20 – 2.29, p=0.002) were significantly associated with CKD progression.

Conclusions:
In a cohort of individuals with CKD stages 3 and 4, serum CPP-II levels demonstrated the strongest association with all-cause mortality, while L-CPP levels showed the strongest association with CKD progression.
Impact of Dialysis Modality on Mortality and Complications in Cardiovascular Surgery
Authors: Shah Ankur , El Shamy Osama , Raker Christina A. , Perl Jeffrey , Hu Susie 
Published: January 2025

Background:
Patients receiving maintenance dialysis face high mortality and complication rates following cardiovascular (CV) surgery. With the growing utilization of peritoneal dialysis (PD), it is important to understand the impact of modality (PD vs. center-based hemodialysis [HD]) on outcomes following CV surgery.

Methods:
This retrospective cohort study used data from the National Inpatient Sample (2016-2020) to compare outcomes of PD and HD patients undergoing coronary artery bypass grafting and surgical valve procedures. Multivariable logistic regression, negative binomial regression, and linear regression models were used, adjusting for demographic factors, comorbidities, and hospital characteristics. The primary outcome was in-hospital mortality, and secondary outcomes included prolonged ventilation, length of stay, and hospital charges.

Results:
A total of 30,155 patients were included in the study, with 28,015 (92.9%) receiving HD and 2,140 (7.1%) receiving PD. Compared to HD, PD was associated with lower in-hospital mortality (OR 0.61, 95% CI 0.38-0.97), reduced prolonged ventilation (OR 0.51, 95% CI 0.32-0.81), shorter length of stay (IRR 0.85, 95% CI 0.80-0.91), and decreased hospital charges (mean difference -$87,172 USD, 95% CI -$113,523 to -$60,820) compared to HD. Among PD patients, post-operative transition to HD was associated with worse outcomes.

Conclusions:
Maintaining PD during the perioperative period may confer benefits over HD, including lower hospital charges and improved patient outcomes. Careful consideration of dialysis modality in the management of CV surgery patients is needed to optimize clinical outcomes and reduce healthcare costs.
Cellulose acetate film containing layered double hydroxide: a new method for determination of soil phosphorus availability
Authors: Castro Gustavo Franco de , Cuesta Rafael Lucas Coca , Duarte Valber Georgio de Oliveira , Mattiello Edson Marcio , Ferreira Jader Alves , Novais Roberto Ferreira , Tronto Jairo 
Published: January 2025

ABSTRACT
Soil nutrient availability and interpretations of nutrient contents are based on the results obtained from specific extraction methods used in routine testing laboratories. The development of new extraction methods and new extractants with better accuracy is particularly important to determine the correct fertilizer rates to be applied. For this purpose, this study aims to synthesize, characterize and evaluate the predictive capacity of cellulose acetate film containing calcinated layered double hydroxide (CAF-LDH-c), as a new extractant and a new method of P extraction in soils. Different analyses techniques were used to characterize the CAF-LDH-c sample, including X-ray diffraction, attenuated total reflectance Fourier transform infrared spectroscopy, and scanning electronic microscopy. Soils were collected from twelve areas with different management and initial availability of P. The soils were subjected to six rates of P and were cultivated with plants. The predictive capacity of CAF-LDH-c, as a new extractant of P in different soils, was evaluated and compared to Mehlich-1 (M-1), Mehlich-3 (M-3), and Mixed Exchange Resin (MER) extractants. Chemical analyses performed on CAF-LDH-c showed that LDH in powder form was incorporated into the cellulose acetate film. There was a linear relation between P uptake by plants and extractable soil P in the soil by CAF-LDH-c, M-1, M-3, and MER extractants. The significant correlations between extracted P in the soil and P uptake by plants for CAF-LDH-c showed the efficacy of the new extractor and the newly proposed method for different types of soils. The results from the present study confirm the possibility of using CAF-LDH-c extractant as a new methodology to evaluate the availability of P in the soil for plant cultivation.
Penerapan Metode Economic Order Quantity dalam Pengendalian Bahan Pendukung Produksi pada Part N01072 di PT. F
Authors: Arifin Fathul , Winarno Winarno 
Published: January 2025

PT. F is a company operating in the automotive sector with products produced in the form of spare parts for cars and motorbikes. The problem faced by this company is the order made by the company when purchasing production-supporting materials which results in excess production-supporting materials, especially oil, this will result in high storage costs for the production-supporting materials and the company will incur additional costs for these expenses. The methods used to control production support materials are Economic Order Quantity (EOQ) and forecasting methods. For the quantity ordered for production support materials, after calculating using the probabilistic model EOQ method, it was found that it was 28 liters of oil per order in the period February 2023 to December 2023. In addition, the company can find out the reorder point and safety stock for the production support materials, each of which is 47 liters. and 41 liters, so that companies are better able to control oil supplies and the problem of excess/shortage of production support materials will not recur.

Keywords: Economic Order Quantity (EOQ), Forecasting, Production Support Materials, Supply
Prerequisites and limitations of the use of oral anticoagulants in pregnant women in real-world clinical practice
Authors: Zagorodnikova Kh. A. , Bettikher O. A. , Zazerskaya I. Ye. 
Published: January 2025

Relevance. Anticoagulants are commonly used during pregnancy is a fairly common practice. Due to the widespread use of oral anticoagulants in real practice and the high frequency of unplanned pregnancy, physicians should assess the risks and plan pregnancy management strategies.Objective. The purpose of this analysis was to assess the legal background and evidence on the risks associated with the use of oral anticoagulants in pregnant women in real-world clinical practice.Materials and methods. An analysis of the official instructions for the use of oral anticoagulants registered in Russia, an analysis of the published literature on reproductive toxicity and the use of drugs during pregnancy, and a general comparative analysis of the predominance of individual oral anticoagulants in practical healthcare in Russia.Results. The results of the analysis revealed high variability in the restrictions on the use of oral anticoagulants during pregnancy. At the same time, the actual evidence of reproductive toxicity for drugs does not differ significantly and indicates the absence of signals of potential teratogenicity, at least based on the available number of observations. The maximum number of pregnancy observations exceeding the number of observations on warfarin use was reported for the use of rivaroxaban (505 cases in the largest analysis). The remaining representatives are described by several dozen observations. In Russia, the use of oral anticoagulants is also a prerequisite for the more likely use of rivaroxaban and apixaban in cases of unplanned pregnancy.Conclusions. In real-world clinical practice, exposure to oral anticoagulants is a prerequisite for pregnancy, which requires decision-making on strategies for pregnancy management. Instructions for the use of drugs do not contain reasonable information or formulations for decision-making based on accumulated knowledge about reproductive toxicity. Based on published data on the use of drugs in this group during pregnancy in real-world clinical practice, there is no sign of teratogenic potential for all representatives, with the exception of warfarin, whereas the largest number of observations concerns the most commonly used rivaroxaban.
REVITALIZING PUBLIC SERVICE: ASSESSING THE SUCCESS OF ONLINE SINGLE SUBMISSION (OSS) POLICY AT INVESTMENT AND INTEGRATED SERVICE OFFICE
Authors: Rahman Fidyawati Abdul , Isa Rusli , Tantu Romy 
Published: January 2025

<p><em>This study aims to determine (1) the implementation of the Online Single Submission (OSS) policy at the Investment and One-Stop Integrated Services Office (DPM-PTSP) of Gorontalo Regency (2) the factors that determine the implementation of the Online Single Submission (OSS) policy at the Investment and One-Stop Integrated Services Office (DPM-PTSP) of Gorontalo Regency. The approach used is qualitative with a type of descriptive research. Data collection using interviews, observation and documentation. Data analysis using the Miles and Huberman model. The results of this study show that (1) The implementation of OSS policy in DPM-PTSP Gorontalo Regency has been implemented quite well and provides benefits in facilitating the licensing service process. The use of the OSS system has helped the OSS user community in carrying out licensing tasks more easily and increased the effectiveness of licensing services in DPM-PTSP. In addition, OSS also provides benefits in increasing productivity and work performance of users in DPM-PTSP. Overall, OSS in DPM-PTSP Gorontalo Regency has proven useful in supporting licensing service tasks but still more must be developed and innovated to be simpler but with better benefits. (2) Factors that determine the implementation of the Online Single Submission (OSS) policy at the Investment and One-Stop Integrated Services Office (DPM-PTSP) of Gorontalo Regency are categorized as quite good because of supporting factors (policy standards and objectives, characteristics of implementing organizations and attitudes of implementers) and some that hinder or have not been effective (resources, communication between organizations and external socioeconomic and political factors), where this shows that various aspects that determine the implementation of OSS policies have been well managed in an effort to improve the efficiency and effectiveness of licensing services. Efforts to implement OSS policies in DPM-PTSP Gorontalo Regency have produced positive impacts and have improved the process of integrated licensing services.</em></p>
PHAST. The Panchromatic Hubble Andromeda Southern Treasury. I. Ultraviolet and Optical Photometry of over 90 Million Stars in M31
Authors: Chen Zhuo , Williams Benjamin , Lang Dustin , Dolphin Andrew , Durbin Meredith , Dalcanton Julianne J. , Smercina Adam , Girardi Léo , Murray Claire E. , Bell Eric F. , Boyer Martha L. , D’Souza Richard , Gilbert Karoline , Gordon Karl , Guhathakurta Puragra , Hammer Francois , Johnson L. Clifton , Lauer Tod R. , Lazzarini Margaret , Murphy Jeremiah W. , Patel Ekta , Quirk Amanda , Díaz Rodríguez Mariangelly , Roman-Duval Julia Christine , Sanderson Robyn E. , Seth Anil , Wainer Tobin M. , Weisz Daniel R. 
Published: January 2025

Abstract
The Panchromatic Hubble Andromeda Southern Treasury (PHAST) is a large 195-orbit Hubble Space Telescope program imaging ∼0.45 deg2 of the southern half of M31's star-forming disk at optical and near-ultraviolet (NUV) wavelengths. The PHAST survey area extends the northern coverage of the Panchromatic Hubble Andromeda Treasury (PHAT) down to the southern half of M31, covering out to a radius of ∼13 kpc along the southern major axis and in total ∼two-thirds of M31's star-forming disk. This new legacy imaging yields stellar photometry of over 90 million resolved stars using the Advanced Camera for Surveys in the optical (F475W and F814W), and the Wide Field Camera 3 (WFC3) in the NUV (F275W and F336W). The photometry is derived using all overlapping exposures across all bands, and achieves a 50% completeness-limited depth of F475W ∼ 27.7 in the lowest surface density regions of the outer disk and F475W ∼ 26.0 in the most crowded, high surface brightness regions near M31's bulge. We provide extensive analysis of the data quality, including artificial star tests to quantify completeness, photometric uncertainties, and flux biases, all of which vary due to the background source density and the number of overlapping exposures. We also present seamless population maps of the entire M31 disk, which show relatively well-mixed distributions for stellar populations older than 1–2 Gyr, and highly structured distributions for younger populations. The combined PHAST + PHAT photometry catalog of ∼0.2 billion stars is the largest ever produced for equidistant sources and is available for public download by the community.
Terminology of didactic wisdom in the ancient Israelite scribal schools as presented in Proverbs 1:1–7
Authors: Mandey Jenry E.C. , Sindoro Pujiastuti E. 
Published: January 2025

Proverbs 1 verses 1–7 encompasses an important section of the Hebrew bible related to ancient didactic wisdom terminology. This article analyses the Masoretic Text in Hebrew to categorise and examine the terminology concerning the theory of the scribal schools that developed in ancient Israel. The issue is the absence of an undisputed indication of the text’s Sitz im Leben. Consequently, the proposal concerning the Sitz im Leben in this text pertains to the scribes. The employed method is textual exegesis, aimed at investigating the text’s background through historical analysis. The study is conducted by examining the terms in each verse, considering their textual meaning and historical contexts, with an emphasis on their usage in scribal schools, to reveal the text’s historical background.Intradisciplinary and/or interdisciplinary implications: This study examined the significance and application of educational terminology in ancient Israel as presented in the introductory passage of the book of Proverbs. This article contributes to historical studies of the ancient education system and biblical studies.
Influence of Gut Microbiome Composition on Surgical Site Infections: A Systematic Review and Meta-analysis
Authors: Aljohani Taghreed Jemaah , Alkatheeri Saba Hussain , Almutiri Teif Nawaf , Alotaibi Hamad Fahad , Alshaiban Saleh Hussain , Kamal Rozana Ibrahim , Sanedi Abdullah Mohammed , Alawad Fatema Hani , Faya Hamad Khalid , Aldanyowi Saud Nayef 
Published: January 2025

Abstract

Introduction:
Post-operative wound infections are dangerous occurrences that happen in various surgical operations. Negative Pressure Therapy (NPT) has been suggested as a method to diminish surgical site infections (SSIs). However, data concerning the effect of this intervention across different types of operations are still lacking.

Objective:
This meta-analysis aimed to evaluate the effectiveness and safety of NPT in reducing SSIs following various surgical procedures.

Materials and Methods:
A systematic review was conducted to identify all randomised controlled trials (RCTs) published between 2020 and 2023 that investigated the efficacy of NPT in reducing post-operative SSIs across different types of surgeries. The outcome measures included SSI incidences and adverse effects. Quality assessment and data extraction were conducted in accordance with the PRISMA flowchart.

Results:
Our meta-analysis included 18 RCTs, encompassing a total of 7,898 patients across different surgical fields such as orthopaedic, gastrointestinal, hepatobiliary, cancer and gynaecology surgeries. The integrated data demonstrated a significant reduction in SSI incidence when comparing the results of NPT application against standard treatment (odds ratio = 0.53; 95% confidence interval = [0.39–0.73], P = 0.0001). This effect remained consistent when subgrouping the studies by different surgical procedures. The safety profile of NPT was found to be acceptable, with no significant increase in adverse effects such as wound dehiscence and hematomas, and a significant decrease in the incidence of wound seroma.

Conclusions:
This meta-analysis supports the use of NPT in reducing SSI rates and endorses its application in post-operative care, particularly in cancer and gastrointestinal surgeries.
A Systematic Review and Meta-analysis Comparing Unicompartmental Versus Total Knee Arthroplasty for Knee Osteoarthritis
Authors: Albeshi Saeed Mubarak , Alsaleh Hussain Mohammed , Altokhais Ziyad Abdullah , Aldawh Ziyad Saad Saeed , Alsulami Amirah Atiah Allah , Almahdi Rahf Hassan , Alrammah Abdulrahman Hamid , Alqurashi Wesal Abdulrahman , Allah Faris Abdullah Saad Al Yaan , Aldanyowi Saud Nayef 
Published: January 2025

Abstract

Background:
Osteoarthritis (OA) affects a significant portion of the population, particularly those aged 45 and above. Total knee arthroplasty (TKA) is the standard treatment for advanced OA, but unicompartmental knee arthroplasty (UKA) is an alternative for patients with OA confined to one compartment. This systematic review and meta-analysis compare the outcomes of UKA and TKA in patients with unicompartmental knee OA.

Materials and Methods:
Following the Cochrane Handbook and Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement’s guidelines, we conducted a systematic review and meta-analysis registered on PROSPERO. Database searches were performed on PubMed, Web of Science and Scopus using relevant keywords. After removing duplicates and screening for eligibility, 10 studies were included. Data extraction and quality assessment were performed independently by four authors, with conflicts resolved by a senior author. Statistical analyses were conducted using Review Manager 5.4.

Results:
A total of 9,751 patients were included, with 3,254 undergoing UKA and 10,649 undergoing TKA. UKA showed statistically significant higher revision rates compared to TKA (odds ratio 2.17; confidence interval 1.63–2.87; I
2 = 53%; P < 0.00001). However, UKA demonstrated superior clinical and functional outcomes, including the Oxford Knee Score, KSS Clinical and WOMAC subscales, along with reduced surgical duration, estimated blood loss and hospital stay.

Conclusions:
UKA offers superior clinical and functional outcomes but with higher revision rates compared to TKA. These findings support UKA for physically active individuals, whereas TKA remains suitable for patients with comorbidities or diminished performance status. Further research with randomised samples and longer follow-up periods is recommended to strengthen the evidence.
A Systematic Review and Meta-analysis of the Effect of Apomorphine in Patients with Parkinson’s Disease
Authors: Aloufi Waad Rabeh , Alabdulaal Maria Raji , Ogran Mohammed Abdulrahman , Alkuhayli Suduf Ali , Alnughaythir Azzam Ibrahim , Almajdua Rehad Ayed , Almojel Rayouf Mohammed , Almalhan Lama Abdulaziz , Alotaibi Ghaida , Alawad Fatema Hani , Al Mohaini Mohammad 
Published: January 2025

Abstract

Introduction:
Regarding a potential relationship between diabetes and the prognostic significance of hyperglycaemia in patients presenting with acute myocardial infarction (AMI), there is still debate. Therefore, we aimed in this study to demonstrate the effect of hyperglycaemia on different outcomes in AMI patients whether they are diabetic or not.

Methods:
Using the following search strategy: ‘Diabetes’ or ‘Diabetic’ AND ‘Acute myocardial infarction’ OR ‘AMI’ AND ‘hyperglycemia’ OR ‘glucose level’, we searched PubMed, Web of Science and Scopus for eligible articles that should undergo the screening process to determine its ability to be included in our study. Using Review Manager version 5.4 software, we conducted the meta-analysis of the included studies by pooling the mean difference (MD) in continuous variables, number and total of dichotomous variables to measure the odds ratio (OR) and generic inverse variance of OR or hazard ratio (HR) as they were reported in the included studies.

Results:
The difference between diabetes and non-diabetes patients regarding blood glucose level was found to be statistically significant with standardised MD of 1.39 (95% confidence interval [CI]: 1.12, 1.66, P < 0.00001). Hyperglycaemia in diabetic patients was statistically significantly associated with mortality with HR of 1.92 (95% CI: 1.45, 2.55, P < 0.00001) and OR of 1.76 (95% CI: 1.15, 2.7, P = 0.01). In non-diabetic patients admitted with AMI, hyperglycaemia was statistically significantly associated with mortality with HR of 1.56 (95% CI: 1.31, 1.86, P < 0.00001) and OR of 2.89 (95% CI: 2.47, 3.39, P < 0.00001). Moreover, hyperglycaemia in diabetic patients admitted with AMI was statistically significantly associated with occurrence of MACE with HR of 1.9 (95% CI: 1.19, 3.03, P = 0.007) and hyperglycaemia in non-diabetic AMI patients was statistically significantly associated with occurrence of MACE with HR of 1.6 (95% CI: 1.15, 2.23, P = 0.006).

Conclusion:
Hyperglycaemia in AMI patients is a predictor of worse outcomes including MACE and mortality whether these patients are diabetic or not. Some factors act as predictors for mortality in these patients including older age, higher glucose levels on admission and high Killip class.