bluuebunny/crossref_metadata_2025_split huggingface dataset:
Resilience mediates the effect of peer victimization on quality of life in Chongqing adolescents: from a perspective of positive childhood experiences
Authors: Deng Liya , Liu Yang , Wang Hong , Yu Junjie , Liao Liping 
Published: July 2023

BackgroundPeer victimization is a harmful experience that contributed to one's psychological problems, physical health deterioration, and so on. Quality of life (QoL) is an important indicator of adolescent health assessment. To identify potential pathways of positive experiences in preventing peer victimization's detrimental effects and then provide intervention ideas for adolescent health, this study was conducted to examine the relationship between peer victimization and QoL in Chongqing adolescents and discover whether resilience plays a mediating role and positive childhood experiences (PCEs) act as a moderating role in the relationship.MethodsData were the first follow-up of a cohort study conducted in four complete middle schools in two districts of Chongqing, China. Self-designed peer victimization items, the Connor–Davidson Resilience Scale, the Adolescent Quality of Life Scale, and the Benevolent Childhood Experiences Scale were used. We investigated the differences and correlations in peer victimization, QoL, and resilience between the two PCEs groups. Mplus version 8.3 was used to analyze the mediating role of resilience and the moderating role of PCEs in peer victimization and QoL.ResultsPeer victimization, resilience, and QoL differed between the two PCEs groups (P &lt; 0.001). Peer victimization negatively correlated with QoL and resilience, while resilience positively correlated with QoL (P &lt; 0.001). In the models with total QOL as the dependent variable, the indirect effect was −0.431 (8.08% of the total effect) in the low-PCEs group vs. −2.077 (41.97% of the total effect) in the high-PCEs group. In the models with four dimensions of QOL as the dependent variable, the indirect effects ranged from −0.054 to −0.180 (6.07–12.95% of the total effects) in the low-PCEs group and from 0.295 to −0.823 in the high-PCEs group (35.89–68.76% of the total effects). Both total and indirect effects were significant (P &lt; 0.05). In addition, the differences in indirect effects were significant between the two PCEs groups (P &lt; 0.05), while differences in total and direct effects were almost not apparent.ConclusionResilience partially mediated the effect of peer victimization on QoL in Chongqing adolescents, and PCEs moderated this mediation. Schools, families, and society should focus on resilience intervention and prioritize the enhancement of PCEs for improving adolescent QoL.
Combined exposure to PM2.5 and PM10 in reductions of physiological development among preterm birth: a retrospective study from 2014 to 2017 in China
Authors: Hu Bo , Tang Jie , Xu Guangtao , Shao Dongliang , Huang Huafei , Li Jintong , Chen Huan , Chen Jie , Zhu Liangjin , Chen Shipiao , Shen Bin , Jin Limin , Xu Long 
Published: July 2023

BackgroundPreterm birth (PTB) has been linked with ambient particulate matter (PM) exposure. However, data are limited between physiological development of PTB and PM exposure.MethodsTrimester and season-specific PM exposure including PM2.5 and PM10 was collected from Jiaxing between January 2014 and December 2017. Information about parents and 3,054 PTB (gestational age &lt; 37 weeks) outcomes such as weight (g), head circumference (cm), chest circumference (cm), height (cm) and Apgar 5 score were obtained from birth records. We used generalized linear models to assess the relationship between PTB physiological developmental indices and PM2.5, PM10 and their combined exposures. A binary logistic regression model was performed to assess the association between exposures and low birth weight (LBW, &lt; 2,500 g).ResultsResults showed that there were 75.5% of low birth weight (LBW) infants in PTB. Decreased PM2.5 and PM10 levels were found in Jiaxing from 2014 to 2017, with a higher PM10 level than PM2.5 each year. During the entire pregnancy, the highest median concentration of PM2.5 and PM10 was in winter (61.65 ± 0.24 vs. 91.65 ± 0.29 μg/m3) followed by autumn, spring and summer, with statistical differences in trimester-specific stages. After adjusting for several potential factors, we found a 10 μg/m3 increase in joint exposure of PM2.5 and PM10 during the entire pregnancy associated with reduced 0.02 week (95%CI: −0.05, −0.01) in gestational age, 7.9 g (95%CI: −13.71, −2.28) in birth weight, 0.8 cm in height (95%CI: −0.16, −0.02), 0.05 cm (95%CI: −0.08, − 0.01) in head circumference, and 0.3 (95%CI: −0.04, −0.02) in Apgar 5 score, except for the chest circumference. Trimester-specific exposure of PM2.5 and PM10 sometimes showed an opposite effect on Additionally, PM2.5 (OR = 1.37, 95%CI: 1.11, 1.68) was correlated with LBW.ConclusionFindings in this study suggest a combined impact of fine particulate matter exposure on neonatal development, which adds to the current understanding of PTB risk and health.
The role of boredom proneness and self-control in the association between anxiety and smartphone addiction among college students: a multiple mediation model
Authors: Zhang Li , Wang Baokai , Xu Qi , Fu Chang 
Published: July 2023

BackgroundSmartphone addiction has been found to be a widespread public health issue, especially among youth. Previous studies reported a significant association between anxiety and smartphone addiction, but the underlying mechanism in this relationship is unclear. The purpose of this study was to investigate the mediating roles of boredom proneness and self-control in the relationship between anxiety and smartphone addiction.MethodsSelf-reported measures of anxiety, boredom proneness, self-control and smartphone addiction were administered to 1,526 Chinese college students.ResultsSmartphone addiction scores varied between 10 and 60 with an average of 30.89 ± 10.57 points. Anxiety had a direct and positive effect on smartphone addiction (effect = 0.18, 95% CI = 0.11–0.25), and an indirect effect on smartphone addiction through boredom proneness (effect = 0.10, 95% CI = 0.06–0.15) and self-control (effect = 0.16, 95% CI = 0.13–0.20). Boredom proneness and self-control sequentially mediated the relationship between anxiety and smartphone addiction (effect = 0.12, 95% CI = 0.10–0.15).ConclusionAnxiety is positively associated with smartphone addiction, and boredom proneness and self-control are important mediators in this relationship. Strengthening self-control and mitigating boredom could prevent smartphone addiction in anxious college students.
The Expression of Epac2 and GluA3 in an Alzheimer’s Disease Experimental Model and Postmortem Patient Samples
Authors: Zhang Tong , Musheshe Nshunge , van der Veen Christina H. J. T. M. , Kessels Helmut W. , Dolga Amalia , De Deyn Peter , Eisel Ulrich , Schmidt Martina 
Published: July 2023

Alzheimer’s disease (AD) is one of the most prevalent neurodegenerative diseases, characterized by amyloid beta (Aβ) and hyperphosphorylated tau accumulation in the brain. Recent studies indicated that memory retrieval, rather than memory formation, was impaired in the early stage of AD. Our previous study reported that pharmacological activation of hippocampal Epac2 promoted memory retrieval in C57BL/6J mice. A recent study suggested that pharmacological inhibition of Epac2 prevented synaptic potentiation mediated by GluA3-containing AMPARs. In this study, we aimed to investigate proteins associated with Epac2-mediated memory in hippocampal postmortem samples of AD patients and healthy controls compared with the experimental AD model J20 and wild-type mice. Epac2 and phospho-Akt were downregulated in AD patients and J20 mice, while Epac1 and phospho-ERK1/2 were not altered. GluA3 was reduced in J20 mice and tended to decrease in AD patients. PSD95 tended to decrease in AD patients and J20. Interestingly, AKAP5 was increased in AD patients but not in J20 mice, implicating its role in tau phosphorylation. Our study points to the downregulation of hippocampal expression of proteins associated with Epac2 in AD.
First Report of Azole-Resistant Aspergillus fumigatus with TR46/Y121F/T289A Mutations in Kuwait and an Update on Their Occurrence in the Middle East
Authors: Asadzadeh Mohammad , Alobaid Khaled , Ahmad Suhail , Mazloum Sara 
Published: July 2023

Pulmonary aspergillosis is a common fungal infection with several clinical manifestations including invasive, allergic and chronic chest diseases. Invasive pulmonary aspergillosis (IPA) is a leading cause of death in immunocompromised patients, particularly those receiving chemotherapy and among bone marrow transplant recipients. Aspergillus fumigatus is the most prevalent causative agent and voriconazole is the first-line therapy for IPA. In this study, we report the first isolation of voriconazole-resistant A. fumigatus carrying TR46/Y121F/T289A mutations from an immunocompromised pregnant lady in Kuwait. The patient was successfully treated for a probable respiratory infection with caspofungin and voriconazole. The literature review from PubMed has identified itraconazole-resistant clinical and environmental A. fumigatus isolates with TR34/L98H mutations in the cyp51A from several Middle Eastern countries including Kuwait. However, clinical A. fumigatus isolates with cyp51A TR46/Y121F/T289A mutations have not been reported previously from any country in the region while environmental isolates have been reported only from Iran. The source of voriconazole-resistant A. fumigatus CYP51A TR46/Y121F/T289A mutant in our patient remained unknown. Surveillance for azole resistance among clinical and environmental isolates of A. fumigatus is warranted in Kuwait.
Modelos de incubación de empresas: Estudio de casos en la Educación Superior de Honduras.
Authors: Barahona Najera Darwin Enrique 
Published: July 2023

El presente artículo pretende identificar los modelos de incubadoras que se utilizan en la educación superior hondureña, tomando como base los dos modelos teóricos puros que plantea Bolla-ti (2015), modelo de incubación tradicional y el modelo de incubación de base tecnológica, para la definición de dichos modelos se toma en consideración una serie de variables planteadas como buenas prácticas de incubadoras definidas en Nodriza (2005), como ser modelo operacional, tipo de servicio, financiamiento, tipo de redes, modelo de negocios y estatus legal de la incuba-dora.
La investigación se realizó con un enfoque cualitativo, bajo un diseño exploratorio utilizando la metodología del estudio de casos múltiples (Yin, 2009). La recolección de datos se llevó a cabo en 2 etapas, la primera etapa incluyó la revisión de artículos científicos y las Webs oficiales de las universidades, y la segunda etapa consistió en entrevistas con responsables de las incubadoras de empresas, mediante un formato de conversación guiada.
Dentro de los resultados encontramos que cinco de veinte universidades hondureñas tienen una incubadora de empresas funcionando, el siguiente hallazgo que la investigación nos revela es que el modelo de incubación prevaleciente es el tradicional.
Como conclusiones se estima que el ecosistema emprendedor a nivel de la educación superior en Honduras, se encuentra aún en fases iniciales, con criterios de admisión bien establecidos y enfocados en emprendedores de sus mismas universidades, dependientes de sus espacios físicos y las redes que se generen alrededor de estos, y en donde aún, no se ha podido comenzar el proceso de transformación hacia incubadoras virtuales.
Influencia del clembuterol-Clb en los procesos homeostáticos que inhibe la conservación de especies criollas en bovinos
Authors: Rivas Ricardo E. Caicedo , Paredes Vladimir Tristán Ruiz , Paz-Calderón Nieto Mariana 
Published: July 2023

El clenbuterol-Clb calificado como un potente bronco-vaso-dilatador, repartidor de grasa, agente tocolitico (retardador del parto), utilizado para controlar enfermedades respiratorias, tanto en animales como en humanos; el Clb es un β2-agonista-adrenérgico (β2-AA), el cual, causa incremento de la masa muscular en aves, bovinos, cabras y ovejas, sin embargo, las rutas metabólicas y el modo de acción hasta el presente no están bien dilucidadas; el objetivo de este estudio consistió en determinar los metabolitos que surgen con la ingesta del clembuterol y sus `posibles derivados que se almacenan en la estructura hepática, páncreas, glándula suprarrenal, músculos y órganos genitales en bovinos. Además, se sabe que el contenido de grasa es reducido dramáticamente cuando el clembuterol es utilizado como anabólico, entendiendo como anabólico, cuando el Clb se administra de forma oral o intramuscular por arriba de la dosis terapéutica, entre 5 y 10 veces su concentración terapéutica (0.8µg/peso corporal dos veces al día). Para este estudio de midieron 17 metabolitos diferentes con el propósito de determinar cuáles son los parámetros metabólicos que son perturbados por este aditivo, y que impiden los procesos de equilibrio intra y extracelular llamado homeostasis, esto a nivel de los diferentes órganos en el que interviene. Se estudiaron 2567 bovinos: el 95% machos y el 5% hembras (Bos taurus X Bos indicus), los resultados revelaron que son varios los metabolitos que son alterados por el clembuterol entre estos tenemos a: a la glucosa, triglicéridos, colesterol, bilirrubina y el Calcio y enzimas a nivel hepático como: fosfatasa alcalina, gamma glutamil transferasa, transaminasas (ALT/GPT y AST/GOT), deshidrogenas láctica; fosfatasa acida: FA-total, FA-prostático y FA-no prostática, los datos muestran que el Clb tiene un efecto en alterar el metabolismo de varias rutas metabólicas; contribuyendo a que posee actividad lipolítica, y anti-lipogénicas e induce a la retención de nitrógeno, aumenta la glicolisis, la producción de lactato y el consumo de oxígeno, incrementa los niveles de glucosa, que varía de acuerdo al tiempo de tratamiento o que es suministrado, ya que a nivel del páncreas disminuye la insulina y los adipocitos son menos sensibles a este aditivo, se detectó el incremento en la utilización de energía y esto produce el aumento de la temperatura corporal llamada termogénesis y que repercute en el desarrollo de patologías en la calidad espermática de los bovinos e infertilidad en hembras bovinas a nivel hormonal, también aumenta los intervalos entre partos-anestro; estas anomalías desarrolladas son activadas por el uso de este aditivo alimenticio Clb. Estos datos determinan que este aditivo tiende a disminuir la sustentabilidad de esta especie.
Análisis de la eficiencia de una planta de experimentación de humedal subsuperficial de flujo vertical para el tratamiento de aguas residuales
Authors: Duque-Sarango Paola , Zagal-Andrade Carlos 
Published: July 2023

La utilización de tecnologías amigables con el medio ambiente como las tecnologías de tratamiento de aguas residuales no convencionales son una alternativa para poblaciones descentralizadas. Los humedales subsuperficiales de flujo vertical son un ejemplo de ello, estos sistemas utilizan sustratos emergentes según la disponibilidad del recurso en el área de implantación, tienen bajos costes de operación y mantenimiento y no requieren de personal especializado. En la presente investigación a escala de microcosmo se evalúa la remoción de materia orgánica y nutrientes de un agua residual urbana, mediante una planta piloto de flujo vertical implantada con sustrato (grava gruesa, roca volcánica, grava fina y una mezcla de turba con abono orgánico) y plantada con la macrófita de la especie Iris pseudacorus. Se realizaron ensayos con tasas de carga hidráulica que oscilaron entre 0.2 y 3 L min-1 y su eficiencia se evaluó mediante el análisis de NH4+, Fe, Ca, Al, P, Cl- libre y total, DBO5 y sólidos presentes. Obteniendo la mayor eficiencia de remoción de DBO con 0.2 L min-1 removiendo el 84%, mientras, para NH4+ y PT con el 60% y 42% respectivamente. Las tasas de remoción promedio de SST y ST fue del 71 y 65%, mientras para Ca, Fe y Al del 80, 53 y 63% respectivamente. Se concluye que es factible utilizar esta tecnología con Iris Pseudacorus en el tratamiento de agua residuales.
Implikasi Kebijakan Persaingan Usaha Produk Usaha Mikro Kecil Menengah (UMKM) Untuk Meningkatkan Perekonomian di Kabupaten Serang
Authors: Sulasno Sulasno , Dwisvimiar Inge 
Published: July 2023

English Version
Small and medium enterprises are one of the breakthroughs in increasing economic growth in the midst of society to achieve adequate welfare. MSME activities train people to have high skills, creativity, and productivity so that they are expected to be able to compete. The existence of business competition requires the Indonesian people to improve their business strategies so that they can compete with other products. This research uses qualitative research (empirical juridical) which is legal research regarding the enforcement or implementation of normative legal provisions in action on every particular legal event that occurs in society. The purpose of this study is to determine the strategy and application of legal protection against business competition products of micro, small and medium enterprises (MSMEs) in Serang Regency and to know the development of legal protection against business competition products of micro, small and medium enterprises (MSMEs) in Serang Regency. The existence of business competition requires the community to improve business strategies so that they are able to compete with other products. One form of legal protection for MSME products is in the form of Intellectual Property Registration (KI). The government assists SMEs in registering IP rights, namely trademark rights and copyrights
Indo Version
Penelitian ini menggunakan penelitian kualitatif (yuridis empiris) adalah penelitian hukum mengenai pemberlakuan atau implementasi ketentuan hukum normatif secara in action pada setiap peristiwa hukum tertentu yang terjadi dalam masyarakat. Tujuan penelitian ini yaitu mengetahui, meemahami, dan menganalisa strategi dan penerapan perlindungan hukum terhadap persaingan usaha produk usaha mikro kecil menengah (UMKM) di Kabupaten Serang dan pengembangan perlindungan hukum terhadap persaingan usaha produk usaha mikro kecil menengah (UMKM) di Kabupaten Serang. Dengan adanya persaingan usaha menuntut masyarakat untuk meningkatkan strategi usaha sehingga mampu bersaing dengan produk-produk lainnya. Pemerintah berupaya dan mendorong terwujudnya para pelaku UMKM dalam melindungi produk-produknya melalui proses permohonan pendaftaran Kekayaan Intelektual (KI) yaitu hak merek maupun hak Cipta. Sementara itu para pelaku UMKM belum mempunyai komitmen yang bisa dipertanggungjawabkan.
The theory of oscillating movement in the soil of a toothed disc colter of a direct seeding grain seeder
Authors: V. V. Adamchuk , V. M. Bulgakov , I. V. Holovach , Ye. І. Ihnatiev 
Published: July 2023

Purpose. Establishing theoretical regularities of oscillatory movements of the disc colter assembly of a direct seeding planter to justify its rational modes, which ensures high-quality sowing of seeds in the soil.
Methods. During the research, methods of the theory of agricultural machines and modeling of technological processes performed by them, methods of higher mathematics, theoretical mechanics, as well as numerical calculations using a personal computer were used.
Results. Compiled differential equations of translational and angular oscillations of the colter unit of the direct seeding planter, which arise under the action of reactions from the soil surface during the movement of the seeding unit along the unevenness of the field surface. The analytical solution of the specified differential equations made it possible to obtain expressions for calculating the frequencies and amplitudes of the studied oscillations depending on the structural and kinematic parameters of the colter unit and the parameters of the soil surface irregularities. On the basis of the obtained analytical expressions, graphical dependences of the amplitude of oscillations of the colter unit of the direct seeding planter on the speed of its translational movement with different stiffness of the springs of the double-spring suspension were constructed.
Conclusions
1.	A rational combination of the design parameters of the seeding unit, the speed of its translational movement, and the parameters of the unevenness of the soil surface, which achieve the necessary quality of seed sowing, is ensured by their determination using the obtained new analytical dependencies.
2.	The obtained expressions for determining the amplitudes and frequencies of vertical oscillations of the colter assembly make it possible to minimize the magnitude of these oscillations and their impact on the quality of seed sowing.
3.	Resonance values of the amplitude of oscillations are obtained when the frequency of disturbances of the colter assembly coincides with the natural frequency at speeds of translational movement of the seeder from 0.6 m s–1 to 1.0 m s–1. In the case of an increase in the speed of movement from 1.2 m s–1 to 4 m s–1 with the stiffness of the springs = 16815–67270 N∙m–1, = 17150–68600 N∙m–1, the indicators of the amplitude of vertical oscillations stabilize and acquire values, which are within 0.01–0.0004 m, respectively.
Keywords: seeder, colter unit, toothed discs, soil surface irregularities, oscillations, differential equations, amplitude, frequency.
УКРАЇНСЬКИЙ ЛЮБОМУДР: ЧИ СПОВНА МИ ВІДКРИЛИ ОРИГІНАЛЬНІСТЬ ФІЛОСОФІЇ ГРИГОРІЯ СКОВОРОДИ
Authors: Saukh Petro 
Published: July 2023

У статті здійснено аналіз оригінальної та самобутньої філософії Григорія Сковороди, яка не вписується у традиційну класичну історико-філософську матрицю. Визначено принципи різних, часто взаємовиключних, версій інтерпретації філософії видатного українського мислителя: від ейфоричного возвеличення до безпідставного приниження. Доведено, що бажанням Г. Сковороди було не відкриття нових принципів чи побудови оригінальної, у чомусь істотно відмінної від усіх інших філософських систем, а прилучення людини до вищих істин буття для практичного втілення їх у повсякденному житті. Його філософія є унікальним прикладом синкретизму самобутньої філософської системи і власної життєвої позиції любомудра. Він жив, як філософствував, і філософствував, як жив. В основі сковородинівського світосприйняття та світорозуміння лежить «вічна філософія» як премудрість. Сила філософії Григорія Сковороди, попри її зовнішню простоту, являє собою знакову літературно-філософську систему, яка поєднала, здавалося б, непоєднувані речі — неоплатонізм із містицизмом, епікурейство з християнством, біблеїзм з елементами античної філософії на основі особливостей української ментальності, ідей духу свободи, справедливості й рівності. Показано, що філософія Григорія Сковороди відкриває перед нами цілісне бачення й сприйняття усього сущого, чого іноді бракує не лише сучасній людині, а й представникам академічної філософії. Її сила і значення запліднює софійність української філософії в контексті ідей антеїзму, кордоцентризму та глибоких екзистенційних мотивів.