bluuebunny/crossref_metadata_2025_split huggingface dataset:
Selective Synthesis of Cyclic Nitroene‐Sulfonamides from Aliphatic Sulfamides and NOBF4
Authors: Huang Quan , Li Sa , Jiang Yuqin , Xia Xiao‐Feng 
Published: May 2023

AbstractDescribed herein is the development of a desaturation and N‐β‐nitration reaction of cyclic amides, which is achieved by a selective hydrogen atom transfer (HAT)/oxidative desaturation/electrophilic nitration process. In this procedure, di‐tert‐butyl peroxide (DTBP) acted both as the oxidant and HAT reagent, and electrophilic NOBF4 as nitration source. Notably, the application of produced cyclic nitroene‐sulfonamides was showcased by their efficient transformations into 3‐piperidones and poly‐substituted piperidine derivatives.
Advanced electrocatalytic materials based biosensors for cancer cell detection – A review
Authors: Sridharan Gokul , Atchudan Raji , Magesh Vasanth , Arya Sandeep , Ganapathy Dhanraj , Nallaswamy Deepak , Sundramoorthy Ashok K. 
Published: May 2023

AbstractHerein, we have highlighted the latest developments on biosensors for cancer cell detection. Electrochemical (EC) biosensors offer several advantages such as high sensitivity, selectivity, rapid analysis, portability, low‐cost, etc. Generally, biosensors could be classified into other basic categories such as immunosensors, aptasensors, cytosensors, electrochemiluminescence (ECL), and photo‐electrochemical (PEC) sensors. The significance of the EC biosensors is that they could detect several biomolecules in human body including cholesterol, glucose, lactate, uric acid, DNA, blood ketones, hemoglobin, and others. Recently, various EC biosensors have been developed by using electrocatalytic materials such as silver sulfide (Ag2S), black phosphene (BPene), hexagonal carbon nitrogen tube (HCNT), carbon dots (CDs)/cobalt oxy‐hydroxide (CoOOH), cuprous oxide (Cu2O), polymer dots (PDs), manganese oxide (MnO2), graphene derivatives, and gold nanoparticles (Au‐NPs). In some cases, these newly developed biosensors could be able to detect cancer cells with a limit of detection (LOD) of 1 cell/mL. In addition, many remaining challenges have to be addressed and validated by testing more real samples and confirm that these EC biosensors are more accurate and reliable to measure cancer cells in the blood and salivary samples.
Gymnema sylvestre extract ameliorated streptozotocin‐induced hyperglycemia in T2DM rats via gut microbiota
Authors: Chen Guilin , Xu Yongbing , Zhang Hui , Muema Felix Wambua , Guo Mingquan 
Published: May 2023

AbstractGymnema sylvestre (GS) has been traditionally used to treat diabetes mellitus (DM) and consumed as both food and medicine. The present work aimed to reveal the arresting hypoglycemic properties of GS leaves on type 2 DM (T2DM) rats meditated by gut microbiota pathway. After administration for 30 days, GS treatment observably improved the abnormal fasting blood glucose (FBG) levels, lipid profiles, and the glucose tolerance of the T2DM rats in a dose‐dependent manner. Furthermore, GS treatment reversibly restored the gut microbiota diversities in the T2DM rats based on the decreased Firmicute abundance and boosted Bacteroidetes abundance and Firmicutes/Bacteroidetes ratio. Particularly, the KEGG pathway suggested that GS treatment strongly interfered with the glucose metabolism processes, such as the glycolysis from glucose 6‐phosphate and glucose, along with the changes in the relative abundances of the beneficial bacteria of Clostridium, Lactobacillus, and Bacteroides. In addition, the GS treatment dramatically promoted the contents of the acetic acid, the total short‐chain fatty acids in the T2DM rat feces. This study showcased the remarkable amelioration of GS on the metabolic disorders of blood glucose and lipids via the regulation of gut microbiota in T2DM rats, which could offer a new mechanism of GS as a potential natural antidiabetic food supplement for T2DM.
The effectiveness of omega‐3 fatty acids on health outcomes in women with breast cancer: A systematic review
Authors: Osouli‐Tabrizi Shirin , Mehdizadeh Amir , Naghdi Mina , Sanaat Zohreh , Vahed Nafiseh , Farshbaf‐Khalili Azizeh 
Published: May 2023

AbstractThis study aimed to systematically evaluate the impact of omega‐3 fatty acids on the health outcomes of women with breast cancer in electronic databases (PubMed, Scopus, ProQuest, Web of Science, and Cochrane Library) for interventional studies. The risk of bias and the quality of the included articles were assessed by Cochrane Collaboration Handbook guidance. The statistical analyses were not conducted because of the heterogeneity of the included studies. Of 3676 identified articles, 11 articles were included in this study. The majority of the included studies were not of high quality. Median progression time and overall survival significantly improved. Additionally, surgical site healing complications and infection rates decreased. There was a significant decrease in perceived stress, sleep disturbance, depression, pain, joint stiffness, and fatigue throughout the intervention. Moreover, omega‐3 fatty acids consumption significantly increased the total serum omega‐3, EPA, and DHA, and decreased the omega‐6: omega‐3 ratio, total leukocytes, lymphocytes, leptin, and CRP, accordingly. Mild gastrointestinal symptoms were reported in only two studies without clinically relevant adverse events. Omega‐3 fatty acids may cause improvement in physical, mental, and some inflammatory and metabolic indices during treatment or posttreatment course of breast cancer patients. Due to the possibility of free radical formation, omega‐3 FAs supplementation and consumption must be done very carefully.
Effects of Cuminum cyminum L. essential oil and its nanoemulsion on oxidative stability and microbial growth in mayonnaise during storage
Authors: Moradi Asma , Davati Nafiseh , Emamifar Aryou 
Published: May 2023

AbstractThe present study aimed to investigate the effects of Cuminum cyminum L. essential oil (CEO) and its nanoemulsion (CEON) on oxidative stability and microbial growth of mayonnaise during storage. The GC analysis indicated that Cuminaldehyde (27.99%), o‐Cymene (17.31%), γ‐Terpinen (16.67%), and β‐Pinene (9.35%) were the major components of CEO, respectively. The assessments of minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) showed that Escherichia coli ATCC 25922 (MBCCEO = 12 and MBCCEON = 6 mg/mL) was the most resistant bacteria, and in contrast, Staphylococcus aureus ATCC 29213 (MBCCEO = 6 and MBCCEON = 3 mg/mL) was the most sensitive bacteria. In the radical‐scavenging assay, CEON (IC50 = 5 ± 0.07 μg/mL) exhibited a higher antioxidant activity than CEO (IC50 = 10 ± 0.13 μg/mL). The results showed that applying the MBC of CEO and CEON in mayonnaise led to a significant decrease (p < .05) in acidity, peroxide value, number of acid‐resistant bacteria and fungi, and total microbial count compared with the control sample. In conclusion, this study demonstrated that using CEON resulted in oxidative stability, microbial growth control, and desirable sensorial attributes in mayonnaise compared with CEO and control samples.
The protective role of maternal genetic immunization on maternal‐fetal health and welfare
Authors: Ahmed Sohail , Jiang Xunping , Liu Guiqiong , Yang Huiguo , Sadiq Amber , Yi Ding , Farooq Umar , Yiyu Sha , Zubair Muhammad 
Published: May 2023

AbstractPregnancy is a critical period associated with alterations in physiologic, biologic, and immunologic processes, which can affect maternal‐fetal health through development of several infectious diseases. At birth, neonates have an immature immune system that makes them more susceptible to severe viral infections and diseases. For this reason, different maternal nutritional and immunization interventions have been used to improve the immune and health status of the mother and her neonate through passive immunity. Here, we reviewed the protective role of maternal immunization with different types of vaccines, especially genetic vaccines, during pregnancy in maternal‐fetal health, immune response, colostrum quality, immune response, and anti‐oxidative status. For this purpose, we have used different scientific databases (PubMed and Google Scholar) and other official web pages. We customized the search period range from the year 2000 to 2023 using the key words “maternal immunization” OR “gestation period/pregnancy” OR “genetic vaccination” OR “maternal‐fetal health” OR “micronutrients” OR “neonatal immunity” “oxidative stress” OR “colostrum quality”. The evidence demonstrated that inactivated or killed vaccines produced significant immune protection in the mother and fetus. Furthermore, most recent studies have suggested that the use of genetic vaccines (mRNA and DNA) during pregnancy is efficient at triggering the immune response in mother and neonate without the risk of undesired pregnancy outcomes. However, factors such as maternal redox balance, nutritional status, and the timing of immunization play essential roles in regulating immune response inflammatory status, antioxidant capacity, and the welfare of both the pregnant mother and her newborn.
Inhibition functions can be improved in children with autism spectrum disorders: An eye‐tracking study
Authors: Caldani Simona , Humeau Elise , Delorme Richard , Bucci Maria Pia 
Published: May 2023

AbstractCognitive remediation therapy interventions could improve cognitive functioning in subjects with autism. To investigate the benefit of a short cognitive training rehabilitation in children with autism spectrum disorder (ASD) on pursuit and fixation performances. We recruited two groups (G1 and G2) of 30 children with ASD, sex‐, IQ‐ and age‐matched (mean 11.6 ± 0.5 years), and pursuit and fixation eye movements were recorded twice at T1 and T2. Between T1 and T2, a 10‐min cognitive training was performed by the G1 group only, whereas the G2 group had a 10‐min of rest. For all children with ASD enrolled in the study, there was a positive correlation between restricted and repetitive behaviour scores of both Autism Diagnostic Interview‐Revised (ADI‐R) and the Autism Diagnostic Observation Schedule (ADOS) and the number of saccades recorded during the fixation task at T1. At T1, oculomotor performances were similar for both groups of ASD children (G1 and G2). At T2, we observed a significant reduction in the number of saccades made during both pursuit and fixation tasks. Our findings underlined the importance to promote cognitive training rehabilitation for children with ASD, leading to a better performance in inhibitory and attention functioning responsible for pursuit and fixation eye movement's performance.
Outcomes of fatty liver disease with and without metabolic comorbidities and risk factors for mortality
Authors: Ogasawara Yuri , Kogiso Tomomi , Horiuchi Kentaro , Taniai Makiko , Tokushige Katsutoshi 
Published: May 2023

AbstractBackground and AimAs the clinical course of metabolic‐associated fatty liver disease (MAFLD) is unclear, we compared the clinical courses of MAFLD and non‐alcoholic FLD (NAFLD).MethodsAsian FLD patients (n = 987) from 1991 to 2021 (biopsy‐proven in 939) were enrolled. The patients were divided into NAFLD (N‐alone, n = 92), both MAFLD and N (M&N, n = 785), and M‐alone (n = 90) groups. Clinical features, complications, and survival rates were compared among the three groups. Risk factors of mortality were subjected to Cox regression analysis.ResultsThe N‐alone group patients were significantly younger (N alone, M&N, and M alone: 50, 53, and 57 years, respectively), more frequently male (54.3%, 52.6%, and 37.8%), and had a low body mass index (BMI, 23.1, 27.1, and 26.7 kg/m2) and FIB‐4 index (1.20, 1.46, and 2.10). Hypopituitarism (5.4%) and hypothyroidism (7.6%) were significantly observed in the N‐alone group. Hepatocellular carcinoma (HCC) developed in 0.0%, 4.2%, and 3.5% of the cases, and extrahepatic malignancies in 6.8%, 8.4%, and 4.7% of the cases, respectively, with no significant differences. The cardiovascular event rate was significantly higher in the M‐alone group (1, 37, and 11 cases, P < 0.01). Survival rates were similar among the three groups. Risk factors for mortality were age and BMI in the N‐alone group; age, HCC, alanine transaminase, and FIB‐4 in the M&N group; and FIB‐4 in the M‐alone group.ConclusionDifferent risk factors for mortality may exist among the FLD groups.
Isothermal titration calorimetry binding properties of Cibacron Blue F3GA in complex with human serum albumin
Authors: Andac Cenk A. , Çağlar Sena , Denizli Adil , Andaç Müge 
Published: May 2023

AbstractBinding interactions between Cibacron Blue‐F3GA (CB‐F3GA) and human serum albumin (HSA, at physiologically ten‐fold lower concentration) was studied by isothermal titration calorimetry (ITC) and in‐silico docking computations. ITC experiments revealed two separate binding sites on HSA with different binding affinities for CB‐F3GA. The high‐affinity binding site (PBS‐II) on HSA binds CB‐F3GA at nanomolar scale (KD1 = 118 ± 107 nM) with favorable binding enthalpy (ΔHo1 = − 6.47 ± 0.44 kcal/mol) and entropy (−TΔSo1 = −2.98 kcal/mol) energies. CB‐F3GA binds to the low‐affinity binding site (PBS‐I) at μM scale (KD2 = 31.20 ± 18.40 μM) with favorable binding enthalpy (ΔHo1 = − 5.03 ± 3.86 × 10−2 kcal/mol) and entropy (−TΔSo1 = −1.12 kcal/mol) energies. ITC binding data strongly suggest that CB‐F3GA binding to PBS‐II site increases the formation of dimeric‐HSA clusters (N1 = 2.43 ± 0.50), while binding to PBS‐I leads to tetrameric‐HSA clusters (N2 = 4.61 ± 0.90). These results suggest that a higher degree of HSA aggregation upon drug binding may be expected under physiological conditions, a notion that should be further investigated for the delivery and toxicity of drug−HSA interactions.
The mental health impact of the COVID‐19 pandemic and exposure to other potentially traumatic events up to old age
Authors: Havermans Demi C. D. , Hoeboer Chris M. , Sobczak Sjacko , Primasari Indira , Coimbra Bruno M. , Hovnanyan Ani , Novakovic Irina Zrnic , Langevin Rachel , Aakvaag Helene F. , Grace Emma , Dragan Malgorzata , Lueger‐Schuster Brigitte , El‐Hage Wissam , Olff Miranda 
Published: May 2023

AbstractWe investigated whether the impact of potentially traumatic events (PTEs) on trauma‐related symptoms changes across the transitional adult lifespan (i.e., 16–100 years old) and if this association differs for self‐reported COVID‐19–related PTEs compared to other PTEs. A web‐based cross‐sectional study was conducted among 7,034 participants from 88 countries between late April and October 2020. Participants completed the Global Psychotrauma Screen (GPS), a self‐report questionnaire assessing trauma‐related symptoms. Data were analyzed using linear and logistic regression analyses and general linear models. We found that older age was associated with lower GPS total symptom scores, B = −0.02, p < .001; this association remained significant but was substantially weaker for self‐reported COVID‐19–related PTEs compared to other PTEs, B = 0.02, p = .009. The results suggest an association between older age and lower ratings of trauma‐related symptoms on the GPS, indicating a blunted symptom presentation. This age‐related trend was smaller for self‐reported COVID‐19–related PTEs compared to other PTEs, reflecting the relatively higher impact of the COVID‐19 pandemic on older adults.
Machinability of AA 2024 aluminum alloy by fiber laser engraving process
Authors: Kasman Ş. , Ozan S. 
Published: May 2023

AbstractThe main objective of the present study is to investigate the machinability of AA 2024‐T351 aluminum alloy by laser beam‐assisted engraving process. The surface in a defined area was machined with the engraving process parameters of scan speed, frequency, and pulse width. While surface roughness measurements were performed to characterize the texture of the processed surface with laser engraving parameters, machining depth measurements were carried out to determine the material removal capacity. In addition, a mathematical relation was built for engraving depth and surface roughness using the response surface methodology. An increase in scan speed and pulse width led to a decrease in engraving depth and surface roughness. Unlike the scan speed and pulse width, any increase in frequency led to increased surface roughness and decreased engraving depth. After processing with lower pulse width and scan speed, a chaotic topography was formed on the surface. The effects of process parameters on engraving depth and surface roughness were analyzed statistically using factorial analysis. Except for the frequency, all parameters for surface roughness were statistically significant, whereas all parameters for engraving depth were statistically significant.
Under (peer) pressure: Experimental evidence on team size and task performance
Authors: Chadi Adrian , Homolka Konstantin 
Published: May 2023

AbstractCausal evidence for the effect of team size on performance is lacking despite the high relevance of this question. From an economic perspective, one would expect performance incentives to decrease with increasing team size, but the psychological phenomenon of peer effects could mitigate the free‐rider problem. To analyze the behavioral implications due to changes in team size, we exploit a rich dataset from a controlled experiment with teams of either two or three participants of a university research project performing a real‐effort task. Our study provides three main findings. First, increasing team size does not change team performance on average, which is a robust result, be it across performance dimensions and even when introducing pay inequality between two work periods. Second, positive performance spillovers from peer to peer alleviate the free‐rider problem when team size increases. Third, changes in peer pressure due to changes in the transparency of others' performance could explain the variation in peer effects across team size. In contrast to discussions in previous literature, our evidence points to a potentially negative role of peer pressure for team performance. While lower peer pressure in teams of three allows for more positive performance spillovers, a high‐skilled peer in a team of two seems to pressure the other team member to produce more mistakes instead of more work output in high quality.
Investigating long‐term creep in a composite pipe subjected to transverse loading and aqueous condition
Authors: Rafiee Roham , Arabian Mohammad Naghi 
Published: May 2023

AbstractGlass‐fiber reinforced‐polymer (GFRP) pipes are widely used in various applications under wet conditions. Despite the considerable efforts on characterizing the mechanical response of GFRP pipes from various viewpoints in dry condition, less attention has been given to the influence of moisture absorption on their performance. The main goal of this research is to investigate the influence of moisture absorption on the long‐term creep behavior of GFRP pipes experimentally and theoretically. As experimental program, a GFRP pipe is subjected to a constant compressive transverse loading while it is submerged in water. Thus, the interaction between creep and water absorption are studied up to 5000 h. A systematic modeling procedure is also developed to evaluate the long‐term wet‐creep response of the GFRP pipes. Two scales of micro and macro are linked through an explicit modeling procedure. An excellent agreement is observed between experimental observations and outputs of the developed modeling procedure.Highlights
A process is developed to model long‐term creep in composites under wet condition.
Long‐term creep is predicted based on short‐term creep behavior of pure resin.
Long‐term creep on immersed pipe in water under the transverse loading is simulated.
Updating constitutive equations, nonlinear viscoelastic behavior is estimated.
The effect of moisture absorption on the long‐term creep behavior is investigated.
Plant height shapes hydraulic architecture but does not predict metaxylem area under drought in Sorghum bicolor
Authors: Lehrer Melissa A. , Hawkins Jennifer S. 
Published: May 2023

AbstractClimate change‐induced variations in temperature and precipitation negatively impact plant growth and development. To ensure future food quality and availability, a critical need exists to identify morphological and physiological responses that confer drought tolerance in agro‐economically important crop plants throughout all growth stages. In this study, two Sorghum bicolor accessions that differ in their pre‐flowering responses to drought were exposed to repeated cycles of drying and rewatering. Morphological, physiological, and histological traits were measured across both juvenile and adult developmental stages. Our results demonstrate that plant height is not predictive of metaxylem area but does influence the hydraulic path and water management in an accession‐specific manner. Further, when drought‐responsive changes to the plant architecture are unable to compensate for the hydraulic risk associated with prolonged drought exposure, tight control of stomatal aperture is crucial to further mitigate hydraulic damage and prevent xylem embolism.
Determination of the degree of substitution of cellulose esters via ATR‐FTIR spectroscopy
Authors: Wolfs Jonas , Scheelje F. Clara M. , Matveyeva Olga , Meier Michael A. R. 
Published: May 2023

AbstractCellulose derivatives are promising bio‐based polymeric materials with possible applications ranging from thickening agents and stabilizers to optical films. The precise determination of their degree of substitution (DS) is crucial, as the DS substantially influences the material properties of such cellulose derivatives. Herein, the applicability of attenuated total reflection‐Fourier transform infrared for DS determination of cellulose esters was investigated. Sixteen cellulose acetates with DS ranging from 0.41 to 2.99 were synthesized and three acetyl group‐specific vibrational signals were evaluated quantitatively in reference to the cellulose anhydroglucose unit vibration ν(CO)AGU. A non‐linear correlation for the absorbance intensity with the DS was observed and the data was fitted based on a newly developed model with correlation coefficients R2 between 0.958 and 0.998, depending on the evaluated signal. This DS determination method is simple and efficient, since it does not need any prederivatization or extensive sample preparation and can furthermore be applied to non‐soluble samples. In order to widen the scope, eight cellulose butyrates, six cellulose laurates and six cellulose benzoates with different DS were synthesized and the DS determination method could be analogously applied to these cellulose esters, but a separate calibration for the different esters was found to be necessary.
Ultrasmall Metal Nanoclusters: Multifunctional Materials Used in Medical Research
Authors: Xin Jingwei , Zou Hongrui , Jiang Yingnan , Zhao Xinyu , Yang Wei , Sun Hui 
Published: May 2023

AbstractUltrasmall metal nanoclusters (NCs) have attracted increasing attention due to their unique characteristics, such as ultrasmall size, fascinating physical and chemical properties, and good biocompatibility, which are desirable for biological and other applications. In recent years, multiple types of NCs have been developed, such as gold NCs, silver NCs, platinum NCs, and copper NCs. These NCs not only play important roles in making chemicals and materials, but some NCs are also used in medical research, showing good prospects due to their advantages. This review summarizes the recent advances in NCs research in the medical field, with particular emphasis on tumor treatment, antimicrobial applications, and bioimaging. Finally, the challenges and outlook of metal NCs in nanomedicine are briefly discussed.