bluuebunny/crossref_metadata_2025_split huggingface dataset:
French mitigation banking: a framework to assess ecological relevance of restoration projects
Authors: Aubry Steve , Gaucherand Stéphanie 
Published: January 2023

AbstractThe implementation of French mitigation bank requires an approval (agrément SNC) delivered by state services through an instruction phase. However, the ecological expectations of state services need to be clarified. To assist stakeholders, we developed an assessment framework whose aim is to specify the useful criteria to justify/determine whether or not a mitigation bank project is ecologically relevant. In this context, we intended to answer the following question: regarding its ecological gains strategy and the site location, is the project suitable to achieve its ecological gains objectives? We define as ecologically relevant a mitigation bank project whose (1) ecological gains strategy is based on acceptable objectives, realistic and operational restauration, management and monitoring measures. This strategy must be (2) consistent with the intrinsic characteristics of the host site(s) and the (3) landscape context in which the project takes place. (4) The respect of the offset principles is ultimately the guiding line of any mitigation project. The different criteria identified through those four assessment components were organized under the form of a project reading grid on which we give more details.
Association between normal-weight obesity and cardiometabolic risk factors among adults in Addis Ababa, Ethiopia
Authors: Gebremedhin Samson , Mekonene Mulugeta , Hagos Seifu , Baye Kaleab , Shikur Bilal , Berhane Adugnaw , Bekele Tilahun 
Published: January 2023

Abstract
Background: The relationship between normal-weight obesity (NWO) – high percent body fat (%BF) in individuals with normal body mass index (BMI) – and cardiometabolic abnormalities has not been explored in Africa. We determined the prevalence of NWO and evaluated its association with hypertension, elevated blood sugar and dyslipidaemia among adults in Addis Ababa, Ethiopia.
Methods: A cross-sectional study was conducted among adults 18-64 years (n=600). Blood pressure, blood glucose, lipid profile, and anthropometric measurements were completed. As function of skinfold thickness, body density and %BF were estimated using Durnin & Womersley and Siri Equations, respectively. The relationship between NWO and the outcomes of interest, assessed using adjusted linear and logit models.
Results: The age- and sex-standardised prevalence of NWO was 18.9% (95% confidence interval (CI): 15.8, 22.2%). Comparison between normal-weight lean (normal %BF and BMI) and normal-weight obese individuals suggested no difference in systolic blood pressure (β=2.55; 95% CI, -0.82, 5.92); however, diastolic blood pressure (β=3.77: 95% CI, 1.37, 6.18) and odds of hypertension (adjusted odds ratio (AOR)=2.46: 95% CI, 1.18, 5.13) were significantly raised in the latter. Similarly, adults with NWO had elevated blood glucose (β=2.30; 95% CI, 1.23, 15.66) and increased odds of high blood sugar level (AOR=1.68; 95% CI, 1.05, 2.67). LDL (β = 8.73: 1.56, 15.90), triglyceride (β=20.99: 0.78, 41.22), total cholesterol (β=10.47: 1.44, 19.50), and Cholesterol to HDL ratio (β=0.65: 0.27, 1.04) were also raised among adults with NWO.
Conclusion: NWO is common among adults in Addis Ababa and is associated with cardiometabolic derangements.
Assessing Multiple Engineering Tasks via Escape Room Game
Authors: Alamanis Nikolaos , Lokkas Philotheos , Xafoulis Nikolaos , Chryssanidis Theodoros , Garani Georgia , Papageorgiou Grigorios , Christodoulou Dimitrios , Paschalis Evangelos , Zachos Dimos 
Published: January 2023

Abstract
Education as a concept includes every effort to train and develop people and their skills by applying the appropriate tools. One type of education is the formal, which includes a logically built and organized curriculum that is under the jurisdiction of state mechanisms. However, there is also a non-formal education which, unlike the formal one, refers to all organized educational programs that take place outside the institutional framework of formal education and are usually voluntary and short in duration. It is mainly addressed to adults and does not have to provide a document certifying education in this field. In this context, the present work, adopting the research methodology based on design, aims to develop and formulate a mobile augmented reality game in the form of escape room/s targeting to train engineers. "Escape Rooms" is the name of an interesting trend of modern times that has flourished in the last decade in many countries around the world. These are puzzle and composition games, in which participants are asked to work together and solve problems using the information that exists in the room/s in order to unlock the door and escape. These types of games belong to the broader category of escape games, but differ from the rest due to the live interaction they provide with the environment. The main benefits of these games are the promotion of collaboration, the development of problem-solving strategies, critical thinking, imagination and creativity, elements that are necessary for the professional activity of an engineer. Escape rooms require teamwork, communication, initiative, as well as critical thinking and attention to detail along with an ability to apply a wide range of knowledge and effective methods under the pressure of time. The purpose of this paper is the evaluation of advanced students, through a series of high level and content of polytechnic questions, in the context of group collaborations that are formed during the coexistence of students in escape rooms, where an augmented reality is incorporated. Finally, the aim of this work is the implementation and evaluation of one or more thematic escape rooms regarding the mobilization, satisfaction and involvement of polytechnic students in puzzles and problems that require significant engineering knowledge.
Multiple Drug-resistant Organism are the main pathogens of colorectal surgery site infection after colorectal surgery: A retrospective study
Authors: Yang Xuexia , Ye Qianqian , Zhou Yangmei , Huang Xun , Li Chunhui , Xiong Yinghui , Tang Yongzhong , Zeng Sainan , Liu Zhenguo , Zhou Pengcheng 
Published: January 2023

Abstract
Background: This study investigates the incidence, disease burden, and risk factors of surgical site infections (SSIs), particularly Multiple Drug-Resistant Organism (MDRO) Infection after colorectal surgery, to provide evidence for the prevention and control of the SSIs after colorectal surgery.
Methods: The study included patients undergoing colorectal surgery between January 1, 2020, and December 31, 2021 at Xiangya Hospital Central South University. Data about demographic information, length of hospital stay, cost of hospitalization, underlying diseases, invasive procedures, and antimicrobial use were gathered via Epidata3.1. A multivariate logistic regression model is used to examine the independent risk factors of SSIs and Multidrug organism infections.
Results: The study included a total of 2297 colorectal surgery patients; 94 patients experienced SSIs following an operation, including superficial incision infection in 18 cases, deep incision infection in 12 cases, and organ compartment infection in 64 cases. In the infection group, 44 cases have multidrug-resistant pathogens, 10 cases have sensitive pathogens, and 40 cases do not have any identifiable pathogens. The pathogen of SSIs in this study is primarily Escherichia coli. It had high cefazolin and cefuroxime resistance, but low resistance to imipenem and piperacillin tazobactam. The median length of stay and hospital costs in the infection group are 27.5 (day) and 85716.96 (yuan), while these figures are 15 (day) and 56318.06 (yuan) in the control group, respectively. All P-values are <0.001. Low preoperative albumin levels, prior use of broad-spectrum antibiotics, preoperative ICU admission, mechanical ventilation, tracheal intubation, central venous catheterization, and blood transfusion are all shown in univariate analysis to be statistically significant risk factors between infection and control group, while mechanical ventilation is shown in multi-factor logistic regression analysis to be the independent risk factor for SSIs. Univariate analysis reveals preoperative hyperglycemia, preoperative ICU admission, mechanical ventilation, and tracheal intubation are all statistically significant risk factors between the MDRO group and NMDR group. Multi-factor logistic regression analysis demonstrates that mechanical ventilation is the independent risk factor for MDRO infection.
Conclusion: The disease burden of SSIs after colorectal surgery is comparatively high, and mechanical ventilation is the independent risk factor for SSIs. MDRO were the most common pathogens of SSIs.
A Novel PEtOx Based Nanogel For Selective Drug Release Targeting Prostate Cancer Cells
Authors: Gülyüz Sevgi , Sessevmez Melike , Ukuser Gokcen , Khalily Melek Parlak , Tiryaki Selen , Sipahioglu Tarik , Birgül Kaan , Özçubukçu Salih , Telci Dilek , Küçükgüzel Ş. Güniz , Durmus Mahmut , Cevher Erdal , Yilmaz Ozgur 
Published: January 2023

Abstract
In this study, prostate cancer-targeted, drug-loaded PEtOx nanogel was prepared by the combination of living/cationic ring-opening polymerization and alkyne-azide cycloaddition “click” chemistry. A fluorescence probe was also conjugated with nanogel to track drug delivery. Nanogel formation was confirmed by 1H-NMR and FT-IR spectroscopies while SEM and DLS analyses showed uniform spherical nanogels and the particle size of nanogels could be controlled at 100-250 nm with relatively narrow size distributions. The physical stability of nanogels has been examined at pH 7.4 and %1-5 fetal bovine serum and intravenously administered nanogel formulations could remain in the bloodstream without much physical change until they reach the target site. The biocompatibility of the nanogels was evaluated using MTT cytotoxicity assays. The results showed that cytotoxicity was dose-dependent and drug-loaded nanogels against cancer cells in vitro were much higher than that of the drug-free nanogel. The targeting efficiency was examined with peptide conjugated and peptide-free nanogel. Intracellular uptake of peptide 563 conjugated nanogel by tumor cells was 60-fold higher than that of nanogel without peptide. Our findings suggest that prepared nanogel exhibits great potential to be used in a variety of drug delivery applications due to non-toxic, and enhanced intracellular uptake into the tumor region.
On the double Roman domination number in oriented trees
Authors: OULDRABAH Lyes , Bouchou Ahmed , Blidia Mostafa 
Published: January 2023

Abstract
Note: Please see pdf for full abstract with equations.
Let D = (V,A) be a digraph. A double Roman dominating function on a digraph D is a function ƒ :V → {0, 1, 2, 3} such that every vertex u for which ƒ(u) = 0 has an in-neighbor v for which ƒ(v) = 3 or at least two in-neighbors assigned 2 under ƒ, while if ƒ(u) = 1, then the vertex u must have at least one in-neighbor assigned 2 or 3. The weight of a double Roman dominating function is the value ƒ(V) = ∑v∈V ƒ(v). The minimum weight of a double Roman dominating function on a digraph D is called the double Roman domination number of D, denoted by γdR (D). This paper gives a descriptive characterization of oriented trees T satisfying γdR(T ) = 2 (n − Δ+) + 1.
2020 Mathematics Subject Classification: 05C20,05C69.
Modelling dissipation, decontamination studies, and risk evaluation of Fipronil + Hexythiazox in Capsicum annum L. fruits via ANOVA using SPSS
Authors: pooja pooja , Ahlawat Sushil , Chauhan Reena , Yadav Surender Singh , Ankisha Ankisha , Ashu Ashu , Kumari Nisha , Pooja Pooja 
Published: January 2023

Abstract
The authors have requested that this preprint be removed from Research Square.
Clavicle plate removal under local anesthesia is preferred as well as under general anesthesia: A case-control study
Authors: Uraya Yuki , Kawano Yusuke , Kuroiwa Takashi , Maeda Atsushi , Funahashi Takuya , Shizu Kanae , Suzuki Katsuji , Fujita Nobuyuki 
Published: January 2023

Abstract
Background: Although implant removal after clavicle fracture is usually conducted under general anesthesia, local anesthesia has mostly been used in our hospital.
Hypothesis: Plate removal following clavicle fracture surgery is painful and distressing for patients if conducted under local anesthesia, and whether patients who have undergone this procedure would prefer it to be performed under general anesthesia should they require similar surgery in the future was conducted.
Methods: The study participants were 56 patients who had undergone plate fixation of a distal clavicle fracture or clavicular shaft fracture in whom plate removal was conducted under local anesthesia at a university hospital, and 183 patients in whom plate removal was conducted under general anesthesia at an acute general hospital. The participants were asked to complete a questionnaire including a question on which method of anesthesia they would prefer should they have to undergo similar surgery in the future.
Results: The patients of both groups responded that they would prefer the same method of anesthesia as before to be used (87.0% of the patients who underwent plate removal under local anesthesia, 78.9 % of the patients underwent plate removal under general anesthesia), with no significant difference between the groups (p > 0.33).
Discussion: Patients who underwent surgery under local anesthesia preferred local anesthesia if they were to undergo it next, even though most of them felt some pain. While surgeons tend to focus only on the patient's distress during surgery, they also find that patients are often dissatisfied during the perioperative period, including bed rest and urinary catheters.
Conclusion: Plate removal under local anesthesia, which was just as acceptable as general anesthesia for the patients.
Level of evidence: Case-control study
Novel Baseline Computational Predictive Model for Seamless Transmission in 5G
Authors: B Archana , Shahabadkar Ramesh 
Published: January 2023

Abstract
5G technologies is known for its beneficial characteristic of supporting largely connected network and high-speed data transmission. With increasing number of services and application meant for hosting over 5G network, there is also an increasing concern towards accomplishing better quality of service and quality of experience in global telecommunication sector. In this line of communication advancement, it is also noted that machine learning is one of the contributories and enabling technology towards boosting the performance of value-added services and applications running on 5G networks. Existing review of literature exhibited multiple variants of methodologies meant for performing predictive performance towards leveraging quality of data delivery services in 5G. However, there are quite many research challenges too that is directly associated with deploying a cost-effective learning scheme in 5G. Therefore, the proposed scheme contributes towards developing a novel and yet simplified baseline architecture which targets to accomplishing seamless and reliable data dissemination services in 5G. The proposed model constructs a novel deployment scenario where a user handheld device is considered as a mobile node with an agenda to considered routing in allocated multiple paths to reach its destination. Further, RFC 8822 is used for deployment 5G standard along with a specific mobility model sync with a real-time server via access point and gateway node in large deployment scenario. Finally, an enhanced Long Short-Term Memory is implemented towards performing identification of predictive routes that are shared to users directly over 5G network. The study outcome is benchmarked with existing learning schemes to exhibit that proposed scheme offers approximately 35% of reduced losses, 19% of higher throughput, 23% of reduced delay, 37% of reduced memory, and 41% of reduced processing time.
miR-17-92 cluster-BTG2 axis regulates B-cell receptor signaling in mantle cell lymphoma
Authors: Kawaji-Kanayama Yuka , Tsukamoto Taku , Nakano Masakazu , Tokuda Yuichi , Nagata Hiroaki , Mizuhara Kentaro , Katsuragawa-Taminishi Yoko , Isa Reiko , Fujino Takahiro , Kimoto-Matsumura Yayoi , Mizutani Shinsuke , Shimura Yuji , Taniwaki Masafumi , Tashiro Kei , Kuroda Junya 
Published: January 2023

Abstract
B-cell receptor (BCR) signaling is critically activated and targetable for mantle cell lymphoma (MCL); however, the underlying mechanism of the activated BCR signaling pathway is not clear. The pathogenic basis of miR-17-92 cluster remains unclear although the oncogenic microRNA (miRNA) miR-17-92 cluster is highly expressed in patients with MCL. This study revealed that miR-17-92 cluster overexpression is partly dependent on SOX11 expression and chromatin acetylation of MIR17HG enhancer regions. Moreover, miR-17-92 cluster regulates not only cell proliferation but BCR signaling activation in MCL cell lines. Pulldown-seq, where mRNA was captured using biotinylated miRNA transfection, was performed and analyzed with next-generation sequencing. Additionally, novel miRNA targets, including tumor suppressors such as BTG2, were identified to comprehensively define miR-17-92 cluster targets. Notably, gene expression profile data of patients with MCL revealed that BTG2 expression was negatively associated with those of BCR signature genes. Moreover, BTG2 silencing in MCL cell lines significantly induced BCR signaling overactivation. Our results suggest an oncogenic role of miR-17-92 cluster-activating BCR signaling throughout BTG2 deregulation in MCL.
Synthesis, Crystal structure, in vitro, and in silico biological studies of 2, 5-dihydroxybenzaldehyde based novel Schiff bases
Authors: todarwal minakshee , Sancheti Rakesh S. , Shah Hakikulla H. , Patil Arvind M. , Patil Rahul D. , Bendre Ratnamala S. 
Published: January 2023

AbstractThe present study reports the synthesis of novel Schiff base ligands (S1-S8) derived from 2, 5-dihydroxybenzaldehyde by coupling with substituted amines. Further, the electron-donating and electron-withdrawing substituents on the amines are intended to tune the properties of the new Schiff base ligands. The chemical structures of these compounds were extensively elucidated by FT-IR,1H-NMR,13C-NMR, and ESI-MS. The X-ray analyses show that the compounds crystallized in a triclinic crystal system with a space group of P-1 and Z = 2 for S1. Besides, antimicrobial potency against gram-positive bacteria and gram-negative bacteria, as well as against fungi, was studied. S3has superior inhibitory activity against all bacterial strains. The consortium of different substituent atoms on the phenyl ring and the heterocyclic ring counterpart is one of the reasons behind the recorded optimal activity. Compound S8has potent antifungal inhibitory action againstC.albicanscompared to the standard antifungal, whereas Schiff base S5also has well to moderate activity against all fungal strains. A molecular docking result indicates that these compounds could also be effective against the resistance β-ketoacyl-ACP (acyl carrier protein) synthase-I enzyme ofE.coli.
Cuticular and glandular chemistry are correlated with ovary size in two populations of the facultatively social carpenter bee, Xylocopa sonorina
Authors: Saleh Nicholas W. , Ostwald Madeleine M. , Ramírez Santiago R. 
Published: January 2023

Abstract
Chemical communication plays a critical role in the organization of insect societies. Although the identity and function of chemical signals in eusocial species have been well-characterized, there is still relatively little understood about the role that chemical communication plays in insects with the simplest forms of social organization. Generally, it is hypothesized that the complex chemical signals of eusocial species evolved from existing fertility-linked chemical variation in solitary species, which then facilitated the formation of reproductive hierarchies as social complexity increased and the reproductive division of labor evolved. Here, we characterize the cuticular and Dufour’s gland chemistry of the facultatively social large carpenter bee, Xyolocopa sonorina, which can form small, fluid social groups that often consist of non-kin and assess whether chemistry is correlated with changes in reproductive status in two populations. We find that compounds from the cuticle and Dufour’s gland show strong correlations with ovary size in both populations. Overall, our results demonstrate that the cuticular and Dufour’s gland chemistry contains reproductive information that could be useful in mediating social interactions in small, simple insect societies.
Which One is Best? Household Solid Waste Collection Facility Siting in a Developing Countries’ Autonomous Region
Authors: Setiawan Eko , Kusuma Juang Victorio , Sulistyawan Ganang Adi , Astuti Septin Puji 
Published: January 2023

Abstract
In many developing countries, the regencies in them have a relatively high degree of autonomy one of which is related to rights to place capacitated waste collection facilities from which the waste is conveyed to final waste clearance facilities. The rights include the management of waste generated by the waste producers at some places yet, due to limited budget, do not touch the waste management at this lowest level at other places. Given the growing importance and emergence of waste-related issues, the paper deals with the problem of siting household solid waste collection facilities within the context of an autonomous region. A waste-weighted P-median, a pure P-median, a P-centre, a P-dispersion and a “distance gap” models are proposed for the problem. By using data obtained from Karanganyar Regency, the Republic of Indonesia, as a problem context, the paper concludes that the best model for the siting problem in such regions is driven by the objective of the siting itself. Moreover, the paper suggests that collection facilities with large capacities should be given a lot more attention in terms of having anticipation to the demand of household solid waste the regions will have in the future.
Minimal non-BFC-rings
Authors: ARTEMOVYCH Orest 
Published: January 2023

Abstract
We study associative rings in which every proper subring is BFC (i.e., has the center of finite index) and obtain a characterization of minimal non-BFC unitary rings of finite characteristic.
2010 Mathematics Subject Classification. 16L30, 20F24, 16N20, 17B60.