bluuebunny/crossref_metadata_2025_split huggingface dataset:
Safety, tolerability, and pharmacokinetics of single and multiple ascending Oral doses of DA‐8010 in healthy subjects: First‐in‐human phase I study
Authors: Lee Dae Young , Lee Min Jung , Ryu Chaelim , Lee Heewon , Brooks Ashley 
Published: February 2023

AbstractThis study assessed the safety, tolerability, and pharmacokinetics of single and multiple oral doses of DA‐8010, a muscarinic M3 receptor antagonist, in healthy subjects. This was a randomized, double‐blind, placebo‐controlled, ascending single (Part A: 1, 2.5, 5, 20, and 40 mg QD fasted and 10 mg QD fasted and fed) and multiple doses (Part B: 5, 10, and 20 mg QD from Days 1 to 7 fasted), sequential‐group study. Safety data were analyzed descriptively, time to maximum plasma concentration (tmax) nonparametrically, and pharmacokinetic parameters using power and mixed models and ANOVA. Of 109 subjects randomized (Part A = 69 and Part B = 40; each part consisted a female group), 31 (44.9%) in Part A and 29 (72.5%) in Part B experienced treatment‐emergent adverse events (TEAEs) in a dose‐related manner. Common drug‐related TEAEs in Part A and B were dizziness (8.7% and 15.0%), headache (5.8% and 12.5%) and blurred vision (8.7% and 20%). One male (20 mg) and one female (10 mg) from Part B discontinued the study due to a confusional state, and nausea and vomiting. Irrespective of sex, DA‐8010 was steadily absorbed following single and multiple doses in the fasted state with increased systemic exposure in a dose‐proportional manner with maximum plasma concentration occurring at a median tmax between 4.0 and 6.0 h. A high‐fat meal increased systemic exposure. DA‐8010 was safe, well tolerated, and well absorbed at lower doses and moderately tolerated at higher doses without any notable effects of food and sex.
Molecularly Hybridized Conduction in DPP‐Based Donor–Acceptor Copolymers toward High‐Performance Iono‐Electronics
Authors: Samal Sanket , Roh Heejung , Cunin Camille E. , Yang Geon Gug , Gumyusenge Aristide 
Published: February 2023

AbstractIono‐electronics, that is, transducing devices able to translate ionic injection into electrical output, continue to demand a variety of mixed ionic–electronic conductors (MIECs). Though polar sidechains are widely used in designing novel polymer MIECs, it remains unclear to chemists how much balance is needed between the two antagonistic modes of transport (ion permeability and electronic charge transport) to yield high‐performance materials. Here, the impact of molecularly hybridizing ion permeability and charge mobility in semiconducting polymers on their performance in electrochemical and synaptic transistors is investigated. A series of diketopyrrolopyrrole (DPP)‐based copolymers are employed to demonstrate the multifunctionality attained by controlling the density of polar sidechains along the backbone. Notably, efficient electrochemical signal transduction and reliable synaptic plasticity are demonstrated via controlled ion insertion and retention. The newly designed DPP‐based copolymers further demonstrate unprecedented thermal tolerance among organic mixed ionic–electronic conductors, a key property in the manufacturing of organic electronics.
Generalized Encapsulations of ZIF‐Based Fe–N–C Catalysts with Controllable Nitrogen‐Doped Carbon for Significantly‐Improved Stability Toward Oxygen Reduction Reaction
Authors: Wu Yongkang , Li Xiaoke , Hua Kang , Duan Xiao , Ding Rui , Rui Zhiyan , Cao Feng , Yuan Mengchen , Li Jia , Liu Jianguo 
Published: February 2023

AbstractThe vigorous development of efficient platinum group metal‐free catalysts is considerably important to facilitate the universal application of proton exchange membrane fuel cells. Although nitrogen‐coordinated atomic iron intercalated in carbon matrix (Fe–N–C) catalysts exhibit promising catalytic activity, the performance in fuel cells, especially the short lifetime, remains an obstacle. Herein, a highly‐active Fe–N–C catalyst with a power density of >1 w cm‐2 and prolonged discharge stability with a current density of 357 mA cm‐2 after 40 h of constant voltage discharge at 0.7 V in H2–O2 fuel cells using a controllable and efficient N–C coating strategy is developed. It is clarified that a thicker N–C coating may be more favorable to enhance the stability of Fe–N–C catalysts at the expense of their catalytic activity. The stability enhancement mechanism of the N–C coating strategy is proven to be the synergistic effect of reduced carbon corrosion and iron loss. It is believed that these findings can contribute to the development of Fe–N–C catalysts with high activity and long lifetimes.
Self‐Boosting Vaccination Based on Pulsatile Antigen Release from Core–Shell Microparticles
Authors: Di Jinwei , Wang Jinyue , Wang Shan , Ma Ming , Zhang Hui , Liu Nan , Zheng Aiping , Gao Xiang , Liu Bo , Gao Jing 
Published: February 2023

AbstractVaccination is among the most effective ways to prevent infectious diseases. Subunit vaccines are safe but usually require multiple booster shots, which may lead to immunity loss and economic consume. In this study, a self‐boosting vaccine is developed based on the pulsatile release of antigen from the core–shell microparticle after single‐injection immunization. Self‐healing technology applied to form an “antigen core” can avoid organic solvents from destroying the spatial structure of the antigen. The “antigen shell” is built‐up by self‐assemble of the antigen with the opposite charged polypeptide. Primary immunization occurs with the self‐assembled film disintegration, and the booster comes with the microparticle degradation. The changing of antigen‐specific antibodies after immunization with the core–shell microparticle vaccine is consistent with that caused by the two shots of immunization. The immune effect and safety evaluation results support the translational potential of this self‐boosting core–shell microparticle vaccine.
In Situ Adjustable Nanogaps and In‐Plane Break Junctions
Authors: Zhao Xueyan , Zhang Xubin , Yin Kaikai , Zhang Surong , Zhao Zhikai , Tan Min , Xu Xiaona , Zhao Zhibin , Wang Maoning , Xu Bingqian , Lee Takhee , Scheer Elke , Xiang Dong 
Published: February 2023

AbstractThe ability to precisely regulate the size of a nanogap is essential for establishing high‐yield molecular junctions, and it is crucial for the control of optical signals in extreme optics. Although remarkable strategies for the fabrication of nanogaps are proposed, wafer‐compatible nanogaps with freely adjustable gap sizes are not yet available. Herein, two approaches for constructing in situ adjustable metal gaps are proposed which allow Ångstrom modulation resolution by employing either a lateral expandable piezoelectric sheet or a stretchable membrane. These in situ adjustable nanogaps are further developed into in‐plane molecular break junctions, in which the gaps can be repeatedly closed and opened thousands of times with self‐assembled molecules. The conductance of the single 1,4‐benzenediamine (BDA) and the BDA molecular dimer is successfully determined using the proposed strategy. The measured conductance agreeing well with the data by employing another well‐established scanning tunneling microscopy break junction technique provides insight into the formation of molecule dimer via hydrogen bond at single molecule level. The wafer‐compatible nanogaps and in‐plane dynamical break‐junctions provide a potential approach to fabricate highly compacted devices using a single molecule as a building block and supply a promising in‐plane technique to address the dynamical properties of single molecules.
Large N partition functions of the ABJM theory
Authors: Bobev Nikolay , Hong Junho , Reys Valentin 
Published: February 2023

Abstract
We study the large N limit of some supersymmetric partition functions of the U(N)k × U(N)−k ABJM theory computed by supersymmetric localization. We conjecture an explicit expression, valid to all orders in the large N limit, for the partition function on the U(1) × U(1) invariant squashed sphere in the presence of real masses in terms of an Airy function. Several non-trivial tests of this conjecture are presented. In addition, we derive an explicit compact expression for the topologically twisted index of the ABJM theory valid at fixed k to all orders in the 1/N expansion. We use these results to derive the topologically twisted index and the sphere partition function in the ’t Hooft limit which correspond to genus g type IIA string theory free energies to all orders in the α′ expansion. We discuss the implications of our results for holography and the physics of AdS4 black holes.
Escaping the interiors of pure boundary-state black holes
Authors: Almheiri Ahmed , Mousatov Alexandros , Shyani Milind 
Published: February 2023

Abstract
We consider a class of pure black hole microstates and demonstrate that they can be made escapable by turning on certain double trace deformations in the CFT. These microstates are dual to BCFT states prepared via a Euclidean path integral starting from a boundary in Euclidean time. These states are dual to black holes in the bulk with an End-of-the-World brane; a codimension one timelike boundary of the spacetime behind the horizon. We show that by tuning the sign of the coupling of the double trace operator to the boundary conditions on the brane the deformation injects negative energy into the black hole causing a time advance for signals behind the horizon. We demonstrate how the property of escapability in the considered microstates follows immediately from the traversability of deformed wormholes. We briefly comment on reconstruction of the black hole interior and state dependence.
Systematic identification of disturbance factors on electric characteristics of mechanical gearboxes
Authors: Becker-Dombrowsky Florian Michael , Hausmann Maximilian , Welzbacher Peter , Harder André , Kirchner Eckhard 
Published: February 2023

AbstractFailures of machine elements can cause critical machine breakdowns, e.g. bearing damage accounts for almost 20% of all machine failures. Hence, monitoring machine elements is of particular importance for condition monitoring of gearboxes. Therefore, new approaches based on electrical impedance analysis are proposed in literature, e.g. for the measurement of rolling bearing load or damage condition with so-called sensory utilizable machine elements (SuME). For this approach, an electrical signal is transmitted through the structure to be observed and the resulting impedance is measured. With this technique it is possible to detect loads and damages not only for bearings, but also for the entire gearbox. Another application of this method can be the transmission of electrical signals through machine elements and the gearbox themselves. However, uncertainty arises with regard to the distinct signal transmission in these processes, mainly due to parasitic capacitances. In this contribution, the disturbing factors on the measured impedance of a gearbox at different working points are investigated. For this purpose, disturbance factors are systematically identified and used as basis for a full factorial experimental design for screening the operational characteristics of a gearbox. The data obtained from the tests is analyzed to identify correlations between the disturbance factors and parasitic capacitances. The experiments show a speed- and torque-dependent behavior of the parasitic capacitances in a gearbox. These results can be used for further research of SuME and structure-integrated energy supply and signal paths as well as the evaluation of related measurement data by reducing the associated uncertainty.
Combining sensitivity and uncertainty analysis to efficiently quantify parametric uncertainties in NVH system simulation models
Authors: Wischmann Stefan , Drichel Pascal , Jacobs Georg , Berges Julius , Berroth Joerg 
Published: February 2023

AbstractThe acoustic and structural dynamic properties of vehicles—often referred to as Noise, Vibration, Harshness (NVH)—form a crucial criterion during product development. To reduce iterations with physical prototypes, NVH simulation models are well established. In early development phases, many parameters of NVH models, such as material and contact properties, are either assumed based on empirical values or have to be measured. In both cases, the value of these parameters is uncertain. Thus, the output of NVH system simulation models such as structure borne or air borne sound is also uncertain and must be quantified. However, applying state-of-the-art uncertainty analysis methods to NVH simulation models considering all uncertain input parameters is inefficient due to their high computation time. Therefore, this paper presents a method of coupled sensitivity (SA) and uncertainty analysis (UA), which enables the efficient uncertainty calculation for NVH simulations. In this method, firstly the most influential parameters are determined using a SA to reduce the number of input parameters. Depending on the number of parameters and the computation time of the NVH simulation model, either the Morris SA or an EFAST SA is chosen. Finally, a fuzzy UA is performed, which quantifies the uncertainty of the output of the NVH simulation and provides its possible ranges. The procedure is applied to the NVH model for predicting air borne sound of an electric drive with 53 uncertain input parameters.
Comparison of the efficacy and safety of selective internal radiotherapy and sorafenib alone or combined for hepatocellular carcinoma: a systematic review and Bayesian network meta-analysis
Authors: Zeng Hao , Zhou Chengyuan , Chen Xiaojing , Hu Lanxin , Su Ke , Guo Lu , Han Yunwei 
Published: February 2023

Abstract
Background
Selective internal radiation therapy (SIRT) is a developing technique and its efficacy and modality of application in hepatocellular carcinoma (HCC) are still controversial. This network meta-analysis aims to determine whether the efficacy and safety of SIRT alone and in combination are superior to that of sorafenib.

Methods
Four databases (PubMed, Embase, Cochrane Library, and Web of Science) were searched before August 2022. Cochrane Randomized Trial Risk of Bias Assessment Tool and the Newcastle–Ottawa scale were used to assess the quality. The outcomes of interest included overall survival (OS), progression-free survival (PFS), and adverse events (AEs).

Results
A total of 9 eligible trials involving 1954 patients were included, and SIRT ranked first among the three treatment modalities in terms of both OS (probability, 52.3%) and PFS (probability, 68.6%). The combination of SIRT and sorafenib did not improve OS or PFS in patients with HCC. Although the combination of SIRT and sorafenib did not raise the risk of grade 3 or higher AEs, it may have introduced more AEs than either alone.

Conclusions
SIRT alone was found to be superior to sorafenib and the combination of the two in improving OS or PFS in patients with non-surgical HCC, especially in patients with combined portal vein tumor thrombus. The AEs induced by SIRT were different from those of sorafenib, but the overall toxicity was manageable, the combination of the two may cause an increase in the types of AEs that occur.
Recordkeeping, logistics, and translation: a study of homeless services systems as infrastructure
Authors: Tracey Pelle , Garcia Patricia , Punzalan Ricardo 
Published: February 2023

AbstractHomeless services systems provide unhoused individuals access to emergency shelter, subsidized housing, and other life-sustaining resources. In this paper, we present a qualitative study that draws on the experiences of fifteen social service workers to examine how recordkeeping practices sustain homeless services systems and unite a tangled web of institutions and actors, including public housing systems, nonprofit agencies, and local governments. We address the following research questions: How is the infrastructure of homeless services sustained by recordkeeping? How are social service workers affected by increasing recordkeeping demands? In what ways do social service workers work against or ‘find the play’ in this system? To address these questions, we collected interviews and conducted artifact walkthroughs with our study participants. We analyzed the data using an infrastructural lens and found that current recordkeeping practices within homeless services systems comprise an "infrastructure of last resort" that functions logistically, prioritizing efficiency and speed. We also found that social service workers “speak back” to logistification by making the homeless services infrastructure more legible to their unhoused clients through mediation and acts of translation that help to produce better resource outcomes. Our findings show how structuring recordkeeping in ways that privilege efficiency and speed disrupts social service work and interferes with social service workers’ ability to provide care for vulnerable individuals facing life-altering and life-threatening hardships.
The Structure of Compulsive Sexual Behavior: A Network Analysis Study
Authors: Marchetti Igor 
Published: February 2023

AbstractCompulsive sexual behavior is a phenomenon characterized by a persistent failure to control intense, repetitive sexual impulses or urges, resulting in repetitive sexual behavior that causes marked distress or impairment in personal, familial, social, educational, or occupational areas of functioning. Despite its major impact on mental health and quality of life, little is known about its internal structure and whether this phenomenon differs across genders, age groups, and risk status. By considering a large online sample (n = 3186; 68.3% males), ranging from 14 to 64 years old, compulsive sexual behavior was explored by means of network analysis. State-of-the-art analytical techniques were adopted to investigate the pattern of association among the different elements of compulsive sexual behavior, identify possible communities of nodes, pinpoint the most central nodes, and detect differences between males and females, among different age groups, as well as between individuals at low and high risk of developing a full-blown disorder. The analyses revealed that the network was characterized by three communities, namely Consequence, Preoccupation, and Perceived Dyscontrol, and that the most central node was related to (perceived) impulse dyscontrol. No substantial differences were found between males and females and across age. Failing to meet one’s own commitments and responsibilities was more central in individuals at high risk of developing a full-blown disorder than in those at low risk.
An integrative study of species distribution modelling and conservation genetics: Magnolia in Hispaniola
Authors: Claerhout Tim , Strubbe Diederik , Castillo Torres Ramón , Samain Marie-Stéphanie , Chatrou Lars W. , Veltjen Emily 
Published: February 2023

AbstractOn the island of Hispaniola, five endemic species of Magnolia occur, all of which are threatened with extinction. Little is known about their distribution and genetic health, hampering targeted conservation actions. The objective of this study is to assess the potential distribution and the genetic health of the Magnolias of Hispaniola, to inform concrete guidelines for effective conservation management. Using species distribution modelling (SDM), we predict habitat suitability for the Magnolias of Hispaniola by analysing 21 variables, describing climate and landscape features, on 635 occurrences. We genotyped 417 individuals using 16 microsatellite markers, to test for genetic structure and degree of inbreeding. The SDM and genetic data confirm the recognition of the four studied Magnolia species. The known individuals of the three Dominican Magnolias are structured into five populations which show ample genetic diversity and little inbreeding overall. For conservation management, we propose to focus on exploration using the SDM results, and protection and reinforcement using the genetic and occurrence data. The genetic results guide prioritization of species and populations. The SDM results guide spatial prioritization. Installing and/or protecting habitat corridors between populations, starting with the two species with the lowest genetic diversity and relatively nearby populations, is recommended as a durable conservation strategy. Meanwhile, reinforcement efforts can be undertaken to artificially increase gene flow for which we appoint sink and source population pairs, using the genetic data.
Coalitional manipulation of voting rules: simulations on empirical data
Authors: Durand François 
Published: February 2023

AbstractUsing computer simulations based on empirical data, we show that seven voting rules that we call the IRV family (Instant-runoff voting, exhaustive ballot, Condorcet-IRV, Benham, Smith-IRV, Tideman and Woodall) are less sensitive to coalitional manipulation than a large selection of prominent voting rules. While the relative performances of these seven rules still deserve further investigation, we show that the differences are at most marginal.
Device-detected atrial fibrillation in a large remote-monitored cohort: implications for anticoagulation and need for new pathways of service delivery
Authors: O’Shea Catherine J. , Brooks Anthony G. , Middeldorp Melissa E. , Harper Curtis , Hendriks Jeroen M. , Russo Andrea M. , Freeman James V. , Gopinathannair Rakesh , Varma Niraj , Deering Thomas F. , Campbell Kevin , Sanders Prashanthan 
Published: February 2023

Abstract
Background
Remote monitoring (RM) can facilitate early detection of subclinical and symptomatic atrial fibrillation (AF), providing an opportunity to evaluate the need for stroke prevention therapies. We aimed to characterize the burden of RM AF alerts and its impact on anticoagulation of patients with device-detected AF.

Methods
Consecutive patients with a cardiac implantable electronic device, at least one AF episode, undergoing RM were included and assigned an estimated minimum CHA2DS2-VASc score based on age and device type. RM was provided via automated software system, providing rapid alert processing by device specialists and systematic, recurrent prompts for anticoagulation.

Results
From 7651 individual, 389,188 AF episodes were identified, 3120 (40.8%) permanent pacemakers, 2260 (29.5%) implantable loop recorders (ILRs), 987 (12.9%) implantable cardioverter defibrillators, 968 (12.7%) cardiac resynchronization therapy (CRT) defibrillators, and 316 (4.1%) CRT pacemakers. ILRs transmitted 48.8% of all AF episodes. At twelve-months, 3404 (44.5%) AF < 6 min, 1367 (17.9%) 6 min–6 h, 1206 (15.8%) 6–24 h, and 1674 (21.9%) ≥ 24 h. A minimum CHA2DS2-VASc score of 2 was assigned to 1704 (63.1%) of the patients with an AF episode of ≥ 6 h, 531 (31.2%) who were not anticoagulated at 12-months, and 1031 (61.6%) patients with an AF episode duration of ≥ 24 h, 290 (28.1%) were not anticoagulated.

Conclusions
Despite being intensively managed via RM software system incorporating cues for anticoagulation, a substantial proportion of patients with increased stroke risk remained unanticoagulated after a device-detected AF episode of significant duration. These data highlight the need for improved clinical response pathways and an integrated care approach to RM.

Trial registration
Australian New Zealand Clinical Trial Registry: ACTRN12620001232921.

Graphical Abstract