bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk of hepatitis B reactivation in HBsAg−/HBcAb+ patients after biologic or JAK inhibitor therapy for rheumatoid arthritis: A meta‐analysis
Authors: Hong Xuezhi , Xiao Yanhua , Xu Liyan , Liu Lei , Mo Hailu , Mo Hanyou 
Published: February 2023

AbstractBackgroundThe risk of hepatitis B virus (HBV) reactivation after biologic and targeted synthetic disease‐modifying antirheumatic drugs (b/tsDMARDs) therapy in patients with rheumatoid arthritis (RA) combined with HBsAg–/HBcAb+ is still inconsistent.MethodsWe conducted a systematic review of existing databases from 1977 to August 22, 2021. Studies of RA patients combined with HBsAg−/HBcAb +, treated with b/tsDMARDs and the reported number of HBV reactivation were included.ResultsWe included 26 studies of 2252 HBsAg−/HBcAb+ RA patients treated with b/tsDMARDs. The pooled HBV reactivation rate was 2.0% (95% confidence interval [CI]: 0.01−0.04; I2 = 66%, p < .01). In the subgroup analysis, the HBV reactivation rate of rituximab (RTX), abatacept, and inhibitors of Janus kinase (JAK), interleukin‐6 (IL‐6), and tumor necrosis factor‐α (TNF‐α) were 9.0% (95% CI: 0.04−0.15; I2 = 61%, p = .03), 6.0% (95% CI: 0.01−0.13; I2 = 40%, p = .19), 1.0% (95% CI: 0.00−0.03; I2 = 41%, p = .19), 0.0% (95% CI: 0.00−0.02; I2 = 0%, p = .43), 0.0% (95% CI: 0.00−0.01; I2 = 0%, p = .87), respectively. While HBsAb‐ patients have a significant risk of reactivation (odds ratio [OR] = 4.56, 95% CI = 2.45−8.48; I2 = 7%, p = .37), low HBsAb+ group also display a significant risk of reactivation (OR = 5.45, 95% CI: 1.35−21.94; I2 = 0%, p = .46).ConclusionsThis meta‐analysis demonstrates the highest potential risk of HBV reactivation in HBsAg−/HBcAb+ RA patients receiving RTX treatment, especially HBsAb− patients. Our study furthers the understanding of the prophylactic use of anti‐HBV drugs in such patients. However, it is relative safety to use the inhibitors of IL‐6, TNF‐α, and JAK in these patients.
Creating Value with MBSE in the High‐Tech Equipment Industry
Authors: Hendriks Teun , van den Aker Joris , Suermondt Wouter Tabingh , Wesselius Jacco 
Published: February 2023

ABSTRACTThe Netherlands has a strong presence in the high‐tech equipment industry sector with world‐wide renowned organizations. Systems engineering is a key capability that is well‐established in this sector. The industry now sees model‐based systems engineering (MBSE) as indispensable to bringing systems engineering capabilities to the next level. Despite this, MBSE is not a fully established practice in this sector as in other industries. ESI has initiated a study to understand the background of the sector's interest in MBSE, the challenges to address with MBSE, experiences with, and fit of current MBSE methodologies versus the characteristics of this sector. This article reports on the results of this study. It highlights innovation in MBSE to address the needs and characteristics of the high‐tech equipment industry.
Merging Agile/DevSecOps into the US DoD Space Acquisition Environment — A Multiple Case Study
Authors: Orosz Michael , Spear Grant , Duffy Brian , Charlton Craig 
Published: February 2023

ABSTRACTOver the past five years, with funding from the US Air Force and the US Space Force, SERC researchers at the University of Southern California's Information Sciences Institute have undertaken a series of case studies that have focused on the introduction of agile and DevSecOps practices into a space‐based software‐only acquisition environment. These studies have identified best practices and revealed useful lessons learned. While the initial baseline DoDI 5000.02 project was entirely waterfall‐based, subsequent projects have introduced agile/DevSecOps methods in progressively increasing levels, with the second project consisting of a roughly a 50/50 hybrid agile/waterfall mix and with the current project consisting of an approximately 70/30 hybrid agile/waterfall mix effort. All projects exhibit similar code complexity and size.
Roxadustat induces hepatotoxicity in zebrafish embryos via inhibiting Notch signaling
Authors: Yang Dou , Xiao Juhua , Wan Mengqi , Liu Jieping , Huang Ling , Li Xue , Zhang Li , Liu Fasheng , Liang Desheng , Zheng Yongliang , Xie Baogang , Liao Xinjun , Xiong Guanghua , Lu Huiqiang , Cao Zigang , Zhang Shouhua 
Published: February 2023

AbstractRoxadustat is a novel and effective small‐molecule inhibitor of hypoxia‐inducible factor prolyl hydroxylase (HIF‐PHI). However, little research has been done on its toxicity to vertebrate embryonic development. In this study, we used zebrafish to assess the effects of roxadustat on early embryonic development. Exposure to 14, 28, and 56 μM roxadustat resulted in abnormal embryonic development in zebrafish embryos, such as shortened body length and early liver developmental deficiency. Roxadustat exposure resulted in liver metabolic imbalance and abnormal liver tissue structure in adult zebrafish. In addition, roxadustat could up‐regulate oxidative stress, and astaxanthin (AS) could partially rescue liver developmental defects by down‐regulation of oxidative stress. After exposure to roxadustat, the Notch signaling is down‐regulated, and the use of an activator of Notch signaling can partially rescue hepatotoxicity. Therefore, our research indicates that roxadustat may induce zebrafish hepatotoxicity by down‐regulating Notch signaling. This study provides a reference for the clinical use of roxadustat.
The intriguing role of the aqueous matrix in advanced water disinfection: can a harmonic relationship be achieved?
Authors: Kyriazi Aphroditi , Gounaki Iosifina , Mantzavinos Dionissios , Venieri Danae 
Published: February 2023

AbstractThis perspective article primarily discusses the role of water matrix for the advanced treatment of watercourses. This relies on experimental work regarding the inactivation of Escherichia coli, Enterococcus faecalis, and Vibrio parahaemolyticus by an advanced oxidation process, namely activated persulfate, in five matrices of varying complexity, (i.e., from as simple as deionized water to secondary treated effluent). For comparison purposes, respective tests were performed with ultraviolet (UVC) radiation, a conventional disinfection process, while results from recent literature are also discussed. Only in deionized water can activated persulfate (i.e., 150 mg L−1 sodium persulfate and 30 mg L−1 ferrous ions) completely inactivate all three bacteria in the course of several minutes, but the process is ineffective in other matrices (i.e., bottled, tap, or lake water, as well as wastewater), where 1–2 orders of magnitude longer times are needed for partial inactivation, which decreases in the order E. coli > E. faecalis ~ V. parahaemolyticus. Conversely, UVC (at 30 W nominal value) is highly efficient against all bacteria and in all matrices in a matter of just a few seconds. The general perception is that treatment efficiency decreases with increasing matrix complexity in terms of total concentration and/or individual components composition, irrespective of the applied treatment method and its objectives (i.e., disinfection, decontamination, or mineralization). However, there are always exceptions the rule, further highlighting how case‐specific advanced water treatment can be. The matrix itself should be given particular emphasis for the rational design of efficient water treatment processes. © 2023 Society of Chemical Industry (SCI).
Characterizing patients hospitalized without an acute care indication: A retrospective cohort study
Authors: Rosenthal Molly A. , Ranji Sumant R. , Kanzaria Hemal K. , Ortiz Gabriel M. , Chase Jack , Chodos Anna H. , Nguyen Oanh K. , Rodriguez Eric G. , Makam Anil N. 
Published: February 2023

AbstractBackgroundHospitalizations by patients who do not meet acute inpatient criteria are common and overburden healthcare systems. Studies have characterized these alternate levels of care (ALC) but have not delineated prolonged (pALC) versus short ALC (sALC) stays.ObjectiveTo descriptively compare pALC and sALC hospitalizations—groups we hypothesize have unique needs.Designs, Settings, and ParticipantsA retrospective study of hospitalizations from March‐April 2018 at an academic safety‐net hospital.Main Outcome and MeasuresLevels of care for pALC (>3 days) and sALC (1–3 days) were determined using InterQual©, an industry standard utilization review tool for determining the clinical appropriateness of hospitalization. We examined sociodemographic and clinical characteristics.ResultsOf 2365 hospitalizations, 215 (9.1%) were pALC, 277 (11.7%) were sALC, and 1873 (79.2%) had no ALC days. There were 17,683 hospital days included, and 28.3% (n = 5006) were considered ALC. Compared to patients with sALC, those with pALC were older and more likely to be publicly insured, experience homelessness, and have substance use or psychiatric comorbidities. Patients with pALC were more likely to be admitted for care meeting inpatient criteria (89.3% vs. 66.8%, p < .001), had significantly more ALC days (median 8 vs. 1 day, p < .001), and were less likely to be discharged to the community (p < .001).ConclusionsPatients with prolonged ALC stays were more likely to be admitted for acute care, had greater psychosocial complexity, significantly longer lengths of stay, and unique discharge needs. Given the complexity and needs for hospitalizations with pALC days, intensive interdisciplinary coordination and resource mobilization are necessary.
Dysregulation of memory B cells and circulating T follicular helper cells is a predictor of poor immune recovery in HIV‐infected patients on antiretroviral therapy
Authors: Liu Yan , Li Zhen , Lu Xiaofan , Kuang Yi‐Qun , Kong Deshenyue , Zhang Xin , Yang Xiaodong , Wang Xiuwen , Mu Tingting , Wang Hu , Zhang Yihang , Jin Junyan , Xia Wei , Wu Hao , Zhang Tong , Moog Christiane , Su Bin 
Published: February 2023

AbstractT follicular helper (Tfh) cells and their interactions with B cells within the germinal center play extensive roles in human immunodeficiency virus (HIV) pathology. However, their association with immune reconstitution during antiretroviral therapy (ART) is still unclear. The aim of this study was to determine the impact of Tfh and memory B cell function on T helper cell recovery in patients with acute or chronic HIV infection. A total of 100 HIV‐infected individuals were enrolled in our study, classified into acute and chronic HIV infection groups (60 and 40, respectively), and subsequently classified into immunological responder (IR) and immunological nonresponder (INR) subgroups according to immune recovery outcomes after 96 weeks of ART. Liquid chromatography‐mass spectrometry was used to quantify the temporal regulation patterns of B and CD4+ T‐cell profiles among patients, and flow cytometry was used to investigate certain subsets of B and T cells. Here we showed that the prevalence of Tfh cells in the T helper cell population correlated negatively with CD4+ T‐cell recovery. The proportion of CXCR3− Tfh cells in patients with acute or chronic infection was associated with CD4+ T‐cell count recovery, and the proportion of CD21+ memory B cells at baseline was significantly higher in those with improved immune recovery outcomes. Universal proteomic dysregulation of B and CD4+ T cells at baseline was detected in patients with acute infected and poor CD4+ T‐cell recovery. Proteomics analysis revealed distinct temporal regulation profiles of both T helper cells and B cells between IRs and INRs among patients with acute infection. Our results suggest that the functions of memory B cells in INRs are dysregulated at the early stage of ART, possibly through disruption of Tfh cell function. The frequency and function of Tfh cells and their subsets are potential predictors of poor immune recovery.
Previous legume crop influences winter barley yield, N fertilizer response, and malting quality in Missouri
Authors: Maw Michael Joseph William , Lepcha Isaac , Naumann Harley D. 
Published: February 2023

AbstractThe rapid growth in the craft brewing industry is increasing the demand for winter barley production. Little recent research exists on producing winter barley for malting in the lower Midwestern United States, with a lack of understanding how previous legumes crops grown in rotation with winter barley interact with nitrogen (N) fertilization rates to affect grain yield and malting quality. To investigate these topics, a preliminary, 1‐year study was conducted in Missouri, USA, to test how growing soybean, a common rotational crop, and sunn hemp, a specialty forage crop, prior to winter barley, as well as two fall N fertilization rates (22.4 and 44.8 kg N ha−1), affected barley grain yield. Barley grain yield was unaffected by the previous legume crop choice or the fall N fertilization rate, suggesting that either crop provided adequate residual N to the succeeding barley crop. Additionally, malting quality was analyzed from representative grain samples to reveal adequate levels suitable for use in the craft brewing industry. This study's results reveal preliminary data supporting winter barley production in the lower Midwestern United States, with an indication that previously grown legume crops impact crop yield greater than fall N fertilizer rate.
Toward Arbitrary Spin‐Orbit Flat Optics Via Structured Geometric Phase Gratings
Authors: Li Chun‐Yu , Liu Si‐Jia , Yu Bing‐Shi , Wu Hai‐Jun , Rosales‐Guzmán Carmelo , Shen Yijie , Chen Peng , Zhu Zhi‐Han , Lu Yan‐Qing 
Published: February 2023

AbstractReciprocal spin‐orbit coupling (SOC) via geometric phase with flat optics provides a promising platform for shaping and controlling paraxial structured light. Current devices, from the pioneering q‐plates to the recent J‐plates, provide only spin‐dependent wavefront modulation without amplitude control. However, achieving control over all the spatial dimensions of paraxial SOC states requires spin‐dependent control of corresponding complex amplitude, which remains challenging for flat optics. Here, to address this issue, a new type of flat‐optics elements termed structured geometric phase gratings is presented, that is capable of conjugated complex‐amplitude control for orthogonal input circular polarizations. By using a microstructured liquid crystal photoalignment technique, a series of flat‐optics elements is engineered and their excellent precision in arbitrary SOC control is shown. This principle unlocks the full‐field control of paraxial structured light via flat optics, providing a promising way to develop an information exchange and processing units for general photonic SOC states, as well as extra‐/intracavity mode convertors for high‐precision laser beam shaping.
Insight on the cellular and molecular basis of blood vessel formation: A specific focus on tumor targets and therapy
Authors: Stephen Nimish Mol , Deepika Udayawara Rudresh , Maradagi Tehreem , Sugawara Tatsuya , Hirata Takashi , Ganesan Ponesakki 
Published: February 2023

AbstractThe cellular and molecular switches that govern angiogenesis are considered therapeutic targets for several diseases like tumors and atherosclerosis. Thus, understanding the detailed molecular mechanisms underlying the formation of the new blood vessel is essential for developing novel therapeutic strategies. The formation of a new blood vessel (angiogenesis) is tightly regulated by balancing pro‐ and antiangiogenic molecules. Dysregulated angiogenesis contributes to the pathogenicity of several diseases, including tumors associated with uncontrolled vessel growth. Experimental and clinical studies emphasize that angiogenesis is a critical step for the transition of the tumor to a life‐threatening malignancy. In recent years, angiogenesis has been targeted as one of the primary therapeutic goals for treating tumors, and rapid progress has been made by modulating its molecular regulators. Hence, the mechanisms of how blood vessel formation occurs could provide molecular insight into future angiogenic therapy. This review summarizes briefly the molecular players of blood vessel formation comprising vasculogenesis and angiogenesis and their role in tumor progression alongside antiangiogenic therapy.
Observer‐based event triggered ADP approach for input‐constrained nonlinear systems with disturbances
Authors: Hu Chuanhao , Zou Yuanyuan , Li Shaoyuan 
Published: February 2023

SummaryThis paper proposes an ADP‐based event‐triggered control (ETC) approach for input‐constrained nonlinear systems with external disturbances to effectively save computational cost. An observer is established to estimate unknown disturbances, and a novel performance index function is introduced to suppress the negative effect of disturbances and tackle the control constraints. Under the event‐triggered mechanism, the corresponding nonquadratic Hamilton‐Jacobi‐Bellman equation is further formulated. With the aid of the modified performance index, an event‐triggered condition is designed to reduce the controller updating times with guaranteed system stability. Furthermore, a single critic neural‐network (NN) is constructed to approximate the optimal control policy by using the ADP technique. In order to relax the requirement of initial admissible control, a modification term is added to the critic weight updating law. According to the Lyapunov stability theorem, the closed‐loop nonlinear system and the weight estimation error of the critic NN are both guaranteed to be uniformly ultimately bounded. Finally, simulation results and comparison studies justify the effectiveness of the proposed ADP‐based ETC method.
HPLC analysis, Phytochemical Content, and Biological Effects of Centaurea kilae Against Some Metabolic Enzymes: In Vitro and In Silico Studies
Authors: Kısa Dursun , Imamoglu Rizvan , Genc Nusret , Taslimi Parham , Kaya Zafer , Taskin‐Tok Tugba 
Published: February 2023

AbstractThe aim of this work was to quantify and identify the phenolic composition of Centaurea kilae Bosse and record the anti‐alzheimer, anti‐urease, anti‐lipase, antidiabetic, anti‐melanogenesis, and antibacterial properties. IC50 values for enzymes were obtained between 0.370–180.1 μg/mL and this plant inhibited HMG_CoA R and urease enzymes more with IC50 values of 0.370 and 39.09 μg/mL, respectively. Furthermore, molecular docking calculations were done subsequently, using targets, HMGCoA_R, glucosidase, amylase, and lipase to detect the structural necessity in activity for the phenolic compounds of Centaurea kilae plant. Chemical compounds of methanolic extracts of Centaurea kilae determined in this work. Finally, antibacterial and antifungal effects of this plant investigated.
Multifunctional Photoabsorber for Highly Efficient Interfacial Solar Steam Generation and Wastewater Treatment
Authors: Mehrkhah Roya , Goharshadi Kimiya , Goharshadi Elaheh K. , Sajjadizadeh Halimeh‐Sadat 
Published: February 2023

AbstractInterfacial solar steam generation (ISSG) is a sustainable and environmental‐friendly technology for seawater desalination and wastewater purification using green and sustainable solar energy. Herein, a robust and efficient interfacial solar steam generation device or photoabsorber for ISSG of seawater and wastewater treatment was designed by coating wood with trace amount of Pd nanoparticles (NPs) and reduced graphene oxide (RGO). High evaporation flux of 5.25 kg m−2 h−1 was achieved by Pd20/RGO80/wood (a piece of wood was coated with 80 and 20 mg L−1 of Pd NPs and RGO as a top and bottom layer, respectively) under 3 kW m−2. The value of electrical conductivity of seawater decreased from 6000.0 to 5.8 μS cm−1 after desalination. The durability test showed the photoabsorber was stable for 30 cycles. The total cost to evaporation rate of the device was calculated as 0.29
0.003 USD/(cm3 h−1). The photoabsorber also showed excellent performance in wastewater treatment in removal of dyes of methylene blue and Reactive blue 5. Also, the concentration of heavy metals of Zn2+, Cd2+, Pb2+, Fe2+, Ni2+, and Cr6+ reduced from 1000 ppm to near zero in the presence of photoabsorber.
Amino acid and Dicyclohexylurea Linked Pyrazole Analogues: Synthesis, In Silico and In Vitro Studies
Authors: Cetin Adnan , Donmez Ali , Dalar Abdullah , Bildirici Ishak 
Published: February 2023

AbstractPancreatic lipase (PL) inhibitors have received considerable attention by several researchers because of its ability to hydrolyse the triglycerides in the small intestine. This study reports the (i) synthesize of new pyrazole derivatives binding amino acid and Dicyclohexylurea (DCU), (ii) their pharmaceutical potentials‐ via enzyme inhibitory activity towards PL and antioxidant activities (using complementary antioxidant methods including FCR, FRAP and ORAC), (iii) the possible interactions between pyrazole compounds and PL enzyme through in silico studies, and the pharmacokinetic properties of the tetra‐substituted pyrazole analogues by PreADMET. Enzyme activities with IC50 values of the pyrazole analogues were found to be in a high range of 6.6±0.4 μM to 13.5±0.2 μM. However, antioxidant activities of the pyrazole analogues exhibited low binding affinities against FCR, FRAP, and ORAC. The pyrazole analogues with docking scores were in the range of −7.3 to −15.2 and their SAR analysis were demonstrated to highlight the importance of amino acid and DCU linked scaffolds. Two web tools were utilized for the purpose of predicting ADMET parameters of drugs and drug‐like pyrazole analogues. These results suggested that the amino acid and DCU linked pyrazole analogues have potential as PL inhibitors.
Recent Advances in the Synthesis of Five‐membered Nitrogen Heterocycles Induced by Palladium Ions and Complexes
Authors: Molnár Árpád 
Published: February 2023

AbstractThis review aims to collect and analyze recent results with respect to the use of varied palladium preparations in the synthesis of five‐membered nitrogen heterocycles including condensed derivatives. Results have been selected with focus on studies of the last three years. Furthermore, a common feature of all methods treated here is that the nitrogen‐containing five‐membered ring is formed via ring closing of appropriate starting materials. Selected examples discussed will reveal that a plethora of products from small monocycles to condensed multi‐ring systems can be successfully accessed. Major features are wide product ranges, high product yields and stereoselectivities often achieved under mild reaction conditions.
Mobile crowdsourced test report prioritization based on text and image understanding
Authors: Wu Yifan , Tong Yao , Liu An , Zhao Lei , Zhang Xiaofang 
Published: February 2023

AbstractIn the process of mobile crowdsourced testing, a large number of test reports are generated, which often consist of short text and rich image information. One of the critical issues is how to review these reports efficiently. Researchers have recently proposed clustering, classification, and prioritization techniques to solve this problem. However, existing studies directly use related technologies to text description and segment the text content without further understanding of the text content. By deeply digging into the text information and distinguishing it according to its actual meaning, the sentences described in the text can be categorized into two types: Describing abnormal system behavior and describing reproduction steps. This paper proposes a mobile crowdsourced test report prioritization technique to improve performance. First, we use a TextCNN trained on large‐scale projects to distinguish the text descriptions of reports, then extract features from the text and screenshot information, respectively. Then we apply a clustering technique to gather similar reports. Finally, the inspection order is sampled from the clustering results. To validate our approach, we conduct experiments on six industrial crowdsourced projects. The results show that our method can detect all bugs faster in a limited time than existing prioritization methods, which can improve the bug reports review efficiency.