bluuebunny/crossref_metadata_2025_split huggingface dataset:
The efficacy and safety of sacubitril/valsartan compared with ACEI/ARB in the treatment of heart failure following acute myocardial infarction: a systematic review and meta-analysis of randomized controlled trials
Authors: Gao Jinquan , Zhang Xin , Xu Mengzhuo , Deng Shisu , Chen Xiaoping 
Published: August 2023

Purpose: To systematically assess the efficacy and safety of sacubitril/valsartan (SV) by comparison with angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin receptor blockers (ARBs) for the treatment of heart failure caused by acute myocardial infarction (HF-AMI) based on current randomized controlled trials (RCTs).Methods: Several electronic databases were searched up to 27 May 2023. Primary endpoints were the efficacy including the left ventricular ejection fraction (LVEF), left ventricular end-diastolic diameter (LVEDD), N-terminal pro-B type natriuretic peptide (NT-proBNP) and 6-min walk test (6MWT) and secondary endpoints were the safety including the major adverse cardiovascular event (MACE) and adverse reaction (AE).Results: A total of 14 RCTs were included and all patients were from China. Among included 1,991 patients, 997 patients received SVs and 994 patients received ACEIs/ARBs. The pooled results demonstrated that patients in the SV group showed significantly better efficacy representing as increased LVEF [weighted mean difference (WMD): 4.43%, 95% confidence interval (CI): 2.84%–6.02%, p &lt; 0.001] and 6MWT (WMD: 30.84 m, 95% CI: 25.65 m–36.03 m, p &lt; 0.001) and decreased LVEDD (WMD: −3.24 mm, 95% CI: −4.96 mm ∼ -1.52 mm, p &lt; 0.001) and NT-proBNP (WMD: −188.12 pg/mL, 95% CI: −246.75 pg/mL ∼ 129.49 pg/mL, p &lt; 0.001), which was also verified by subgroup analysis based on the history of percutaneous coronary intervention (PCI). Besides, the SV group showed significantly lower incidence rate of MACE [relative risk (RR): 0.60, 95% CI: 0.47–0.75, p &lt; 0.001] and patients receiving SVs in the non-PCI group also showed lower incidence of AE (RR: 0.38, 95% CI: 0.20–0.71, p = 0.002).Conclusion: For the treatment of HF-AMI, SV is more effective and safer than ACEI/ARB based on current evidence, but more high-quality RCTs are still needed to verify above findings.
Development of critical K dilution curves for diagnosing sweetpotato K status
Authors: He Weichen , Li Jing , Lu Yanjun , Chen Shaojie , Deng Lijuan , Xu Ximing , Zhu Yueming , Jin Minghuan , Liu Yuheng , Lu Guoquan , Lv Zunfu 
Published: August 2023

Scientific and reasonable application of potassium fertilizer is an important agronomic measure to achieve high yield and high quality of sweetpotato, and it is of great significance to determine the appropriate amount of potassium fertilizer in the field. For this we constructing a model of the critical K dilution curve (CKDC) of sweetpotato under different N levels to determine crop nutritional statuses. In this study, a 3-year field experiment was conducted in Zhejiang Province in China, using two nitrogen levels (N0: 0 kg ha−1 and N1: 120 kg ha−1) and five K fertilization rates (K0: 0, K1: 75, K2: 150, K3: 225, K4: 300 kg ha−1) for two sweetpotato cultivars of ‘Shang 19’ and ‘Yan 25’. Plant dry matter first increased and then decreased and the K concentration increased continuously with an increase in K application rate. The required amount of K fertilizer to achieve maximum sweetpotato yield under high N conditions was greater than that under low nitrogen conditions. A new CKDC based on dry matter and K concentration was created to assess K nutrition in sweetpotato. At two N levels, CKDC was expressed by the negative power function equation, aboveground: Kc(N0)=5.30W-0.463, R2 = 0.79, and Kc(N1)=4.23W-0.298, R2 = 0.78, under-ground: Kc(N0)=1.38W-0.125, R2 = 0.81, and Kc(N1)=1.32W-0.132, R2 = 0.72;whole-plant: Kc(N0)=4.31W-0.421, R2 = 0.80; Kc(N1)=3.89W-0.415, R2 = 0.79. There is no significantly different for CKDC of whole-plant and underground between N0 and N1 levels, while there is significantly different for CKDC of aboveground between N0 and N1 levels. N fertilizer can strengthen the dilution effect of K concentration, and its effect on the aboveground is greater than that on the underground and whole-plant. Then, potassium nutrition indexes were constructed to identify K nutrition status and could be used as a reliable indicator for K nutrition diagnosis of sweetpotato. The results provide a theoretical basis to improve K fertilization management and sustainability of sweetpotato.
An empirical study on the collaborative usability of age-appropriate smart home interface design
Authors: Zhou Chengmin , Zhan Wenjing , Huang Ting , Zhao Hanxiao , Kaner Jake 
Published: August 2023

IntroductionThe smart home has become a popular product, but with the development of the aging population, the differentiated characteristics of the elderly smart home products in terms of demand and use are becoming more and more significant. The existing smart products are complicated to operate and cumbersome to interact with, which increases the cognitive load of the elderly group and hinders the daily use and user experience feeling of the elderly. The purpose of this paper is to study the interface data information and interface visual design starting from hardware and software, interface interaction, to explore the better interface data information and interface visual design, and to output, a new prototype of the operating interface of smart home system for the elderly, so that the smart products can be better used by the elderly.MethodsThirty-two participants aged 55–75 were invited to conduct the test, and subjective evaluation was conducted at the end of the test. Through the tests, the operability of the prototype structure for smart furniture systems for the elderly was demonstrated.ResultsIn terms of functionality a new task based on a combination of icons and text is proposed. In the control of devices, the switching status of devices, etc., needs to be clearly distinguished visually, eye-protective bright colors are used, paired with low saturation to highlight the focus, and high bright colors with gray to distinguish the device status. In terms of the density of the content, an appropriate proportion of images and text were used to make the information less dense. ln the arrangement of web content, information content relevant to users was placed first as much as possible.DiscussionBased on this, a secondary optimal design was carried out to improve the interactive design of the smart home for the elderly and output it as a prototype interactive interface. Thus, the operability, rationality, and aesthetic comfort of the prototype design of smart home interaction in an age-friendly scenario are improved, allowing the elderly to have a better experience when using the smart home.
What we know about grief intervention: a bibliometric analysis
Authors: Li Jie , Li Yuan , Wang Yali , Jishi Wuga , Fang Jinbo 
Published: August 2023

BackgroundGrief is a natural and individualized response to different losses, but if grief persists or becomes pathological, professional interventions are required. Grief and corresponding interventions have received increasing attention, as the related concepts have been incorporated into the DSM-5 and ICD-11. Therefore, we conducted a bibliometric analysis to explore the developments in the field of grief intervention research.MethodsArticles on grief interventions were systematically searched and screened from the Web of Science Core Collection. The retrieved data were analyzed and visualized using VOSviewer and Bibliometrix software for journals, authors, institutions, countries, references, and keywords.ResultsA total of 9,754 articles were included. The number of articles on grief interventions has increased significantly each year since 1990. Death Studies was the journal that published the most articles in this field. We identified 25,140 authors contributed to this research area and these authors were from 123 countries and 6,630 institutions. Boelen PA secured the first position in article production, Columbia University emerged as the most productive affiliation and the United States was the foremost leading in grief intervention research. The prevalent keywords utilized in this field comprised bereavement, grief, death, depression, and palliative care.ConclusionThe quantity of publications regarding grief interventions is increasing. Although most prior studies have focused on mortality, grief, and health, emerging themes such as COVID-19, grief among workers, and disfranchised grief have drawn increasing attention in recent years. Future studies may focus on investigating the complexities and challenges of grief, including its underlying mechanisms and impact on mental well-being.
Predictors of treatment dropout in patients with posttraumatic stress disorder due to childhood abuse1
Authors: Bremer-Hoeve Susanne , van Vliet Noortje I. , van Bronswijk Suzanne C. , Huntjens Rafaele J.C. , de Jongh Ad , van Dijk Maarten K. 
Published: August 2023

BackgroundKnowledge about patient characteristics predicting treatment dropout for post-traumatic stress disorder (PTSD) is scarce, whereas more understanding about this topic may give direction to address this important issue.MethodData were obtained from a randomized controlled trial in which a phase-based treatment condition (Eye Movement Desensitization and Reprocessing [EMDR] therapy preceded by Skills Training in Affect and Interpersonal Regulation [STAIR]; n = 57) was compared with a direct trauma-focused treatment (EMDR therapy only; n = 64) in people with a PTSD due to childhood abuse. All pre-treatment variables included in the trial were examined as possible predictors for dropout using machine learning techniques.ResultsFor the dropout prediction, a model was developed using Elastic Net Regularization. The ENR model correctly predicted dropout in 81.6% of all individuals. Males, with a low education level, suicidal thoughts, problems in emotion regulation, high levels of general psychopathology and not using benzodiazepine medication at screening proved to have higher scores on dropout.ConclusionOur results provide directions for the development of future programs in addition to PTSD treatment or for the adaptation of current treatments, aiming to reduce treatment dropout among patients with PTSD due to childhood abuse.
Magnitude of placebo response in clinical trials of paroxetine for vasomotor symptoms: a meta-analysis
Authors: Rhodes Joshua R. , Alldredge Cameron T. , Elkins Gary R. 
Published: August 2023

IntroductionVasomotor symptoms, or hot flashes, are among the most common complaints for menopausal and postmenopausal women. As an alternative to hormone replacement therapy, paroxetine mesylate became the only non-hormonal treatment approved by the U.S. Food and Drug Administration (FDA), despite limited evidence for its efficacy. More specifically, there is uncertainty around paroxetine's unique benefit and the magnitude of the placebo response in clinical trials of paroxetine.MethodsRelevant databases were searched to identify randomized clinical trials examining the efficacy of paroxetine to treat hot flashes. The primary outcomes of interest were hot flash frequency and hot flash severity scores. Data was extracted from the published results, and risk of bias assessments were conducted.ResultsSix randomized clinical trials that included a total of 1,486 women were coded and analyzed. The results demonstrated that 79% of the mean treatment response for hot flash frequency is accounted for by a placebo response, resulting in a mean true drug effect of 21% at most. Additionally, 68% of the mean treatment response for hot flash severity is accounted for by a placebo response, resulting in a maximum true drug effect of 32%.DiscussionThe results herein call into question the actual efficacy of the only FDA approved, non-hormonal treatment for hot flashes by demonstrating that a placebo response accounts for the majority of treatment responses for reductions in both hot flash frequency and severity. The findings provide evidence to reevaluate the use of paroxetine to treat postmenopausal hot flashes and emphasize the importance of considering effective, alternative treatments for vasomotor symptoms.
Identifying circulating biomarkers for major depressive disorder
Authors: Zhang En , Huang Zhongfei , Zang Zongjun , Qiao Xin , Yan Jiaxin , Shao Xuefei 
Published: August 2023

ObjectiveTo date, the current diagnosis of major depressive disorder (MDD) still depends on clinical symptomatologic criteria, misdiagnosis and ineffective treatment are common. The study aimed to explore circulating biomarkers for MDD diagnosis.MethodsA high-throughput antibody array technology was utilized to detect 440 circulating cytokines in eight MDD patients and eight age–and gender-matched healthy controls. LASSO regression was conducted for MDD-related characteristic proteins selection. Enzyme-linked immunosorbent assay (ELISA) was used to validate the characteristic proteins in 40 MDD patients and 40 healthy controls. Receiver operating characteristic (ROC) curve was employed to evaluate the diagnostic values of characteristic proteins for discriminating MDD patients from healthy controls. Correlations between the levels of characteristic proteins and depression severity (HAMD-17 scores) were evaluated using linear regression.ResultsThe levels of 59 proteins were found aberrant in MDD patients compared with healthy controls. LASSO regression found six MDD-related characteristic proteins including insulin, CD40L, CD155, Lipocalin-2, HGF and LIGHT. ROC curve analysis showed that the area under curve (AUC) values of six characteristic proteins were more than 0.85 in discriminating patients with MDD from healthy controls. Furthermore, significant relationship was found between the levels of insulin, CD155, Lipocalin-2, HGF, LIGHT and HAMD-17 scores in MDD group.ConclusionThese results suggested that six characteristic proteins screened from 59 proteins differential in MDD may hold promise as diagnostic biomarkers in discriminating patients with MDD. Among six characteristic proteins, insulin, CD155, Lipocalin-2, HGF and LIGHT might be useful to estimate the severity of depressive symptoms.
A study on the emotional and attitudinal behaviors of social media users under the sudden reopening policy of the Chinese government
Authors: Zhang Qiaohe , Niu Tianyue , Yang Jinhua , Geng Xiaochen , Lin Yinhuan 
Published: August 2023

IntroductionSince the outbreak of the COVID-19 pandemic, the Chinese government has implemented a series of strict prevention and control policies to prevent the spread of the virus. Recently, the Chinese government suddenly changed its approach and lifted all prevention and control measures. This sudden change in policy is expected to lead to a widespread outbreak of COVID-19 in China, and the public and local governments are not adequately prepared for the unknown impact on society. The change in the “emergency” prevention and control policy provides a unique research perspective for this study.MethodsThe purpose of this study is to analyze the public's attitudes and emotional responses to COVID-19 under the sudden opening policy, identify the key factors that contribute to these attitudes and emotions, and propose solutions. In response to this sudden situation, we conducted data mining on topics and discussions related to the opening of the epidemic on Sina Weibo, collecting 125,686 interactive comments. We used artificial intelligence technology to analyze the attitudes and emotions reflected in each data point, identify the key factors that contribute to these attitudes and emotions, explore the underlying reasons, and find corresponding solutions.ResultsThe results of the study show that in the face of the sudden release of the epidemic, the public mostly exhibited negative emotions and behaviors, with many people experiencing anxiety and panic. However, the gradual resumption of daily life and work has also led some people to exhibit positive attitudes.ConclusionThe significance of this study is to help the government and institutions understand the impact of policy implementation on users, and to enable them to adjust policies in a timely manner to respond to potential social risks. The government, emergency departments, and the public can all prepare for similar situations based on the conclusions of this study.
Bouncing back from COVID-19: a Western Australian community perspective
Authors: Sarasjärvi Kiira Karoliina , Chivers Paola , Bhoyroo Ranila , Codde Jim 
Published: August 2023

IntroductionThis study explored the behavioral profiles of residing Western Australians during a COVID-19 lockdown period and transitions in behavior post-lockdown.MethodsA total of 313 participants (76% female, age: M = 50.1, SD = 15.7 years) completed behavioral and mental health questionnaire items ~2 months after a 3-month COVID-19 lockdown in October 2020, using a retrospective recall to assess their experience during the lockdown period. Latent transition analysis (LTA) was used to identify behavioral profiles and transitions. Indicators were identified by assessing during–post-lockdown group differences (Kruskal–Wallis, chi-square tests) and profiles described using qualitative open-ended questions.ResultsSignificant indicators included changes in physical activity, leisure screen time, alcohol intake, psychological distress, and loneliness, but not fast food consumption. The significant indicators were used to form LTA models. The five latent class model showed the best model fit (Log-likelihood = −1301.66, AIC = 426.12, BIC = 609.68). Approximately one in four participants reported a change in their behavior profiles after the lockdown ceased. Key differences between the profiles were age, household income, education, resilience, sense of control, existing mental health issues, and social relations. Washing hands and social distancing were the most recalled and effective health campaigns across the classes, with health campaigns encompassing physical activity/alcohol consumption, or domestic violence having the least attention.DiscussionOverall, while most participants recovered relatively well after the lockdown period, LTA did identify subgroups such as those who were inactive and lonely experienced more difficulties than other groups, and engagement with public health campaigns differed. The results provide important insights for future public health campaigns on how these campaigns might be diversified to effectively target more people and particular groups to maximize engagement for maintaining people's mental health with additional focus on physical activity, alcohol consumption, and domestic violence.
MOSAIC, an example of comprehensive and integrated social and health care: care and practices oriented towards personal recovery
Authors: Cano-Prieto Ivan , Prat-Vigué Gemma , Vilanova-Masana Rut , Guillaume-Cornet Aida , Giralt Palou Rosa , Lana-Francos Gemma , Simó-Algado Salvador 
Published: August 2023

BackgroundThe Mosaic project is a socio-health integration model that promotes the personal recovery of people with severe mental illness in a territory of Central Catalonia: the Bages region. The recovery approach in mental health care promotes meaningful activities and social inclusion for people with mental health disorders. The aim of this study is to examine the relationship between the level of meaningful activities and other factors associated with the mental health recovery model.MethodsA cross-sectional design was used. Participants (n = 59) signed an informed consent and completed the following standardized instruments: Engagement in Meaningful Activities Survey; The Connor-Davidson Resilience Scale; Hert Hope Scale; and Recovery Assessment Scale.ResultsA Pearson correlation test was performed between the level of meaningful activities and life satisfaction, resilience, hope, and recovery. These data indicate that the amount of meaningful activities are strongly associated with variables related to the personal recovery process from mental health problems.ConclusionsThe integration process of MOSAIC confirms the need to accompany the recovery processes through significant occupations.
Prinsip Kepemimpinan Moral Spiritual Sekolah Dalam Pembangunan Karakter PAUD di TK Nurul Hidayah Kabupaten Serdang Bedagai
Authors: Harahap Hotni Sari , Armanila Armanila 
Published: August 2023

Early childhood education is a fundamental educational process. Children at an early age will find it very easy to imitate or imitate what they see so that with the ability of the principal to display leadership that emphasizes the moral-spiritual aspect, it will be able to help early childhood in shaping their character. This study aims to find out how spiritual-moral-based principal leadership can improve character learning. The research method uses a descriptive qualitative approach. The results of the study show that through a moral-spiritual leadership approach there are three stages in the formation of character, namely moral knowing; moral feeling; and moral action is easier to implement through the learning process. As input material for school principals, they should choose a moral-spiritual leadership approach in forming character, namely moral knowing; moral feeling; and moral action is easier to implement through the learning process. The selection of the right spiritual-moral leadership approach can influence the formation of the character of student achievement.

ABSTRAK
Pendidikan anak usia dini merupakan proses pendidikan yang fundamental. Anak di usia dini akan sangat mudah dalam meniru atau mencontoh apa saja yang dilihatnya sehingga dengan kemampuan kepala sekolah menampilkan kepemimpinan yang menonjolkan pada aspek moral spiritual akan mampu membantu anak usia dini dalam membentuk karakternya. Penelitian ini bertujuan untuk mengetahui bagaimana kepemimpinan kepala sekolah berbasis moral spiritual mampu meningkatkan pembelajaran karakter. Metode penelitian menggunakan pendekatan kualitatif deskriptif. Hasil penelitian menunjukkan bahwa melalui pendekatan kepemimpinan moral spiritual tiga tahapan dalam pembentukan karaktek yakni moral knowing; moral feeling; dan moral action lebih mudah diimplementasikan melalui proses pembelajaran. Sebagai bahan masukan bagi kepala sekolah sebaiknya memilih pendekatan kepemimpinan moral spiritual dalam pembentukan karaktek yakni moral knowing; moral feeling; dan moral action lebih mudah diimplementasikan melalui proses pembelajaran. Pemilihan pendekatan kepemimpinan moral spiritual yang tepat dapat berpengaruh terhadap dalam pembentukan karaktek pencapaian prestasi belajar siswa.