bluuebunny/crossref_metadata_2025_split huggingface dataset:
Psychometric validation of the generalized pustular psoriasis physician global assessment (GPPGA) and generalized pustular psoriasis area and severity index (GPPASI)
Authors: Burden A. David , Bissonnette Robert , Lebwohl Mark G. , Gloede Tristan , Anatchkova Milena , Budhiarso Ismail , Hu Na , Thoma Christian , Skalicky Anne M. , Bachelez Hervé 
Published: March 2023

AbstractBackgroundGeneralized pustular psoriasis (GPP) is a rare and life‐threatening skin disease often accompanied by systemic inflammation. There are currently no standardized or validated GPP‐specific measures for assessing severity.ObjectiveTo evaluate the reliability, validity and responder definitions of the Generalized Pustular Psoriasis Physician Global Assessment (GPPGA) and Generalized Pustular Psoriasis Area and Severity Index (GPPASI).MethodsThe GPPGA and GPPASI were validated using outcome data from Week 1 of the Effisayil™ 1 study. The psychometric analyses performed included confirmatory factor analysis, item‐to‐item/item‐to‐total correlations, internal consistency reliability, test–retest reliability, convergent validity, known‐groups validity, responsiveness analysis and responder definition analysis.ResultsUsing data from this patient cohort (N = 53), confirmatory factor analysis demonstrated unidimensionality of the GPPGA total score (root mean square error of approximation <0.08), and GPPGA item‐to‐item and item‐to‐total correlations ranged from 0.58 to 0.90. The GPPGA total score, pustulation subscore and GPPASI total score all demonstrated good test–retest reliability (intraclass correlation coefficient: 0.70, 0.91 and 0.95 respectively), and good evidence of convergent validity. In anchor‐based analyses, all three scores were able to detect changes in symptom and disease severity over time; reductions of −1.4, −2.2 and − 12.0 were suggested as clinically meaningful improvement thresholds for the GPPGA total score, GPPGA pustulation subscore and GPPASI total score respectively. Anchor‐based analyses also supported the GPPASI 50 as a clinically meaningful threshold for improvement.ConclusionsOverall, our findings indicate that the GPPGA and GPPASI are valid, reliable and responsive measures for the assessment of GPP disease severity, and support their use in informing clinical endpoints in trials in GPP.
Black and white proxy experiences and perceptions that influence advanced dementia care in nursing homes: The ADVANCE study
Authors: McCarthy Ellen P. , Lopez Ruth Palan , Hendricksen Meghan , Mazor Kathleen M. , Roach Ashley , Rogers Anita Hendrix , Epps Fayron , Johnson Kimberly S. , Akunor Harriet , Mitchell Susan L. 
Published: March 2023

AbstractBackgroundRegional, facility, and racial variability in intensity of care provided to nursing home (NH) residents with advanced dementia is poorly understood.Materials and MethodsAssessment of Disparities and Variation for Alzheimer's disease NH Care at End of life (ADVANCE) is a multisite qualitative study of 14 NHs from four hospital referral regions providing varied intensity of advanced dementia care based on tube‐feeding and hospital transfer rates. This report explored the perceptions and experiences of Black and White proxies (N = 44) of residents with advanced dementia to elucidate factors driving these variations. Framework analyses revealed themes and subthemes within the following a priori domains: understanding of advanced dementia and care decisions, preferences related to end‐of‐life care, advance care planning, decision‐making about managing feeding problems and acute illness, communication and trust in NH providers, support, and spirituality in decision‐making. Matrix analyses explored similarities/differences by proxy race. Data were collected from June 1, 2018 to July 31, 2021.ResultsAmong 44 proxies interviewed, 19 (43.1%) were Black, 36 (81.8%) were female, and 26 (59.0%) were adult children of residents. In facilities with the lowest intensity of care, Black and White proxies consistently reported having had previous conversations with residents about wishes for end‐of‐life care and generally better communication with providers. Black proxies held numerous misconceptions about the clinical course of advanced dementia and effectiveness of treatment options, notably tube‐feeding and cardiopulmonary resuscitation. Black and White proxies described mistrust of NH staff but did so towards different staffing roles. Religious and spiritual beliefs commonly thought to underlie preferences for more intense care among Black residents, were rarely, but equally mentioned by race.ConclusionsThis report refuted commonly held assumptions about religiosity and spirituality as drivers of racial variations in advanced dementia care and revealed several actionable facility‐level factors, which may help reduce these variations.
Modern pandemic crises and default risk: Worldwide evidence
Authors: Ho Kung‐Cheng , Huang Hung‐Yi , Pan Zikui , Gu Yan 
Published: March 2023

AbstractThis article examines the relationship between modern health pandemic crises and financial stability. Specifically, it collects data on 250,223 firms in 43 countries (or regions) during five modern pandemic crises, SARS (2003), H1N1 (2009), MERS (2012), Ebola (2014), and Zika (2016), and finds that pandemic crises significantly increase the default risk of enterprises. Further analysis shows that formal and informal institutions acted as a “cushion” against the pandemic crisis. The earlier a country adopts IFRS, the more unimpeded access to information, and the more stable religious and ethnic relations within the country can reduce the negative impact of a pandemic on financial stability. This article addresses the hitherto inadequacy of COVID‐related data. In addition, this article argues that governments should build sound state institutions to withstand macroeconomic shocks and highlights the heterogeneity of default risk for enterprises operating in countries with different institutions.
Estado, políticas públicas y comunidades: Aportes para repensar la antropología del Estado desde América Latina
Authors: Fuica Rebolledo Inti Fernando , Henríquez Noelia Carrasco 
Published: March 2023

AbstractThe anthropology of the state is an important field to generate knowledge regarding the state's work. In Latin America, it has had an interesting development, with shared theoretical bases. In this article we present diverse methodological applications related to this field of study in the region and explore conceptually the relationship between the state and communities. We also propose adding anthropology of public policies as part of this approach.
The Fundamental Review of the Trading Book: Implications for Portfolio and Risk Management in the Banking Sector
Authors: MCCULLAGH ORLA , CUMMINS MARK , KILLIAN SHEILA 
Published: March 2023

AbstractThe Fundamental Review of the Trading Book (FRTB) is the promised overhaul of bankmarket risk regulation. FRTB retains the authorized use of proprietary risk models, however, it introduces two additional criteria: (i) P&L attribution (PLA) tests and (ii) desk‐level backtests. We examine empirically whether these additional criteria influence risk management and portfolio management practice, specifically portfolio construction and choice of risk model. We find that the PLA tests demand significant alignment with risk factors, however, the backtests do not incentivize use of superior risk models. This has important implications for the efficacy of the capital‐based regulatory system.
Living with pulmonary sequelae of COVID‐19 and the implications for clinical nursing practice: A qualitative systematised review
Authors: Albright Cameron , Limoges Jacqueline , Rempel Gwen R. 
Published: March 2023

AbstractAimTo synthesise qualitative research on pulmonary sequelae of COVID‐19 and identify patient needs and experiences to develop nursing care strategies.BackgroundQualitative research on long COVID by subtype has not yet occurred. As pulmonary sequelae constitute a serious long COVID subtype, exploring patient experience and needs can generate knowledge to guide nursing practice.DesignSystematised review methodology utilised on a purposive sample of published articles and reported using the PRISMA guidelines and checklists. Searched MEDLINE, Cumulative Index to Nursing and Allied Health, and Google Scholar, for English or French articles published from February 2020 to June 2022; qualitative research with adults recovering from COVID‐19 with evidence of pulmonary sequelae.MethodsEstablished principles for data extraction followed related to data reduction, data presentation, data comparison, and conclusion formulation and verification. Analysis was informed by Thorne's Interpretive Description and extended with Meleis' transitions theory, Mishel's uncertainty in illness theory and Moore et al.'s holistic theory of unpleasant symptoms. The quality of included studies was assessed Joanna Briggs Institute critical appraisal tool for qualitative research.ResultsFour articles with six pooled participants provided data to yield three main themes: (1) a novel health‐illness transition, (2) lung injury and pulmonary fibrosis as antecedent to illness uncertainty, (3) and pulmonary symptoms that are compounded by fatigue and weakness.ConclusionPulmonary sequelae of COVID‐19 confers a unique health‐illness transition, uncertainties and symptoms that can be addressed by theory informed nursing practice.Relevance to Clinical PracticeAdvocacy, optimising the nurse–patient relationship, offering up‐to‐date information and addressing uncertainty may help patients cope with pulmonary sequelae, a complex subtype of long COVID with important considerations for clinical nursing care. Despite a lack of evidence‐informed clinical pathways, nurses can support patients to understand novel treatments, support discharge planning and acknowledge the synergistic nature of pulmonary symptoms and fatigue to support health‐illness transitions.No Patient or Public ContributionThis article involved analysis of previously published works.
Timing of preference submissions under the Boston mechanism
Authors: Chen Li 
Published: March 2023

AbstractThis paper considers a model of centralized college admission under the Boston mechanism where students may have uncertainty about their priorities. Students have homogeneous ordinal preferences over colleges, but their preference intensities vary, and the exam scores determine their priorities. In equilibrium, student application strategies take a cutoff form. The strategies depend on their exam scores under post‐score submissions, on preference intensities under pre‐exam submissions, and on both preference intensities and signals about their exam scores under pre‐score submissions. Given these equilibrium strategies, students are better off under pre‐exam and pre‐score submissions than post‐score submissions. When students with the same preference intensities and exam scores receive signals of different qualities, those with bad signals could be hurt by those with good signals.
RNA‐seq analysis of soybean (Glycine max) responding to Phytophthora sojae
Authors: Li Ping , Liu Dong , Hu Jiulong , Yu Bixia 
Published: March 2023

AbstractPhytophthora sojae is a devastating pathogen of soybean [Glycine max (L.) Merr.] that causes Phytophthora root and stem rot (PRR) on soybean plants worldwide. The pathogen leads to evident differentiation of pathogenicity which brings some difficulties to the control of the disease. Soybean germplasm plays an important role in disease resistance to P. sojae. To understand the role of soybean in the pathogen differentiation of P. sojae, transcriptome sequencing and biological information technology were used to analyse the difference in transcriptional level of soybean response to P. sojae infection by two isolates BB8 and BZ9 with different pathogenicity. A total of 1596 differentially expressed genes (DEGs) were screened from the soybean plants treated with the strong pathogenic isolate BB8 and weak pathogenic isolate BZ9, of which 256 were upregulated and 1340 were downregulated in BZ9 treated samples. Gene Ontology analysis revealed that the highly enriched terms annotated in biological processes were metabolic process, cellular process and single‐organism process. Kyoto Encyclopedia of Genes and Genomes pathways were distributed primarily in metabolism, environmental information processing and cellular processes. Photosynthesis‐antenna proteins, photosynthesis, phenylpropanoid biosynthesis, carbon fixation in photosynthetic organisms, plant hormone signal transduction, flavonoid biosynthesis, carbon metabolism and nitrogen metabolism were the most substantial metabolic pathways. Ten candidate DEGs were selected and their expression levels were detected via fluorescence quantitative polymerase chain reaction. The expression trends were basically consistent with the results of RNA‐seq detection, confirming the reliability of RNA‐seq data. Taken together, this was the report on the transcriptome analysis of soybean in response to P. sojae using high‐throughput sequencing. A number of DEGs and pathways were discovered, which provided valuable information for obtaining high‐quality soybean resistance resources.
Validation of Plateletworks ADP for the ProCyte Dx analyzer
Authors: Kornya Matthew R. , Abrams‐Ogg Anthony C. G. , Blois Shauna L. , Wood R. Darren 
Published: March 2023

AbstractBackgroundPlatelet function testing in cats allows determination of clopidogrel effect. Plateletworks assesses aggregation based on decreasing platelet counts on hematology analyzers in response to agonists. It has not been validated for the IDEXX ProCyte Dx analyzer. Ideal time to perform analysis and the utility of other platelet parameters have not been fully assessed.ObjectivesTo validate Plateletworks ADP on the ProCyte Dx, to investigate the utility of various platelet parameters using Plateletworks ADP, and determine the ideal time to perform analysis.AnimalsTwenty healthy cats recruited from the general population used for transference of reference intervals to a new analyzer, and 10 cats receiving clopidogrel to determine clopidogrel effect.MethodsPlateletworks ADP using the ProCyte Dx and ADVIA 2120i analyzer was run simultaneously in both healthy cats and cats receiving clopidogrel, and CBC results at different timepoints were compared between analyzers.ResultsAggregation was significantly different (P < .001) between analyzers. Cohen's kappa showed almost perfect agreement for determination of clopidogrel effect, and the area under the curve of the receiver operating characteristic was 1.0. Lower limits of the aggregation reference interval in healthy cats were 28.8% on the ProCyte Dx and 12.5% on the ADVIA 2120i. Coefficients of variation for platelet parameters were not different between analyzers. No significant changes in mean platelet volume, plateletcrit, large platelets, and mean platelet component were identified. No significant change in aggregation was observed within the first hour after phlebotomy.Conclusions and Clinical ImportanceOur study validated the Plateletworks ADP system on the ProCyte Dx analyzer. Samples may be analyzed up to 1 h after collection.
Emergence and clonal expansion of Vibrio aestuarianus lineages pathogenic for oysters in Europe
Authors: Mesnil Aurélie , Jacquot Maude , Garcia Céline , Tourbiez Delphine , Canier Lydie , Bidois Audrey , Dégremont Lionel , Cheslett Deborah , Geary Michelle , Vetri Alessia , Roque Ana , Furones Dolors , Garden Alison , Orozova Petya , Arzul Isabelle , Sicard Mathieu , Charrière Guillaume M. , Destoumieux‐Garzón Delphine , Travers Marie‐Agnès 
Published: March 2023

AbstractCrassostrea gigas oysters represent a significant global food source with 4.7 million tons harvested per year. In 2001, the bacterium Vibrio aestuarianus subsp. francensis emerged as a pathogen that causes adult oyster mortality in France and Ireland. Its impact on oyster aquaculture has increased in Europe since its re‐emergence in 2012. To better understand the evolutionary mechanisms leading to the emergence and persistence over time of this pathogen, we conducted a survey of mollusc diseases through national reference laboratories across Europe. We analysed 54 new genomes of Vibrio aestuarianus (Va) isolated from multiple environmental compartments since 2001, in areas with and without bivalve mortalities. We used a combination of comparative genomics and population genetics approaches and show that Va has a classical epidemic population structure from which the pathogenic Va francensis subspecies emerged and clonally expanded. Furthermore, we identified a specific cus‐cop‐containing island conferring copper resistance to Va francensis whose acquisition may have favoured the emergence of pathogenic lineages adapted and specialized to oysters.
Perspective elucidating the physiology of a microbial cell: Neidhardt's Holy Grail
Authors: Sawers R. Gary 
Published: March 2023

AbstractA living microbial cell represents a system of high complexity, integration, and extreme order. All processes within that cell interconvert free energy through a multitude of interconnected metabolic reactions that help to maintain the cell in a state of low entropy, which is a characteristic of all living systems. The study of macromolecular interactions outside this cellular environment yields valuable information about the molecular function of macromolecules but represents a system in comparative disorder. Consequently, care must always be taken in interpreting the information gleaned from such studies and must be compared with how the same macromolecules function in vivo, otherwise, discrepancies can arise. The importance of combining reductionist approaches with the study of whole‐cell microbial physiology is discussed regarding the long‐term aim of understanding how a cell functions in its entirety. This can only be achieved by the continued development of high‐resolution structural and multi‐omic technologies. It is only by studying the whole cell that we can ever hope to understand how living systems function.
Avoiding and allowing apatite precipitation in oxygenic photolithotrophs
Authors: Raven John A. 
Published: March 2023

SummaryThe essential elements Ca and P, taken up and used metabolically as Ca2+and H2PO4−/HPO42−respectively, could precipitate as one or more of the insoluble forms calcium phosphate (mainly apatite) if the free ion concentrations and pH are high enough. In the cytosol, chloroplast stroma, and mitochondrial matrix, the very low free Ca2+concentration avoids calcium phosphate precipitation, apart from occasionally in the mitochondrial matrix. The low free Ca2+concentration in these compartments is commonly thought of in terms of the role of Ca2+in signalling. However, it also helps avoids calcium phosphate precipitation, and this could be its earliest function in evolution. In vacuoles, cell walls, and xylem conduits, there can be relatively high concentrations of Ca2+and inorganic orthophosphate, but pH and/or other ligands for Ca2+, suggests that calcium phosphate precipitates are rare. However, apatite is precipitated under metabolic control in shoot trichomes, and by evaporative water loss in hydathodes, in some terrestrial flowering plants. In aquatic macrophytes that deposit CaCO3on their cell walls or in their environment as a result of pH increase or removal of inhibitors of nucleation or crystal growth, phosphate is sometimes incorporated in the CaCO3. Calcium phosphate precipitation also occurs in some stromatolites.
Lumbar Sympathetic Trunk Injury: An Underestimated Complication of Oblique Lateral Interbody Fusion
Authors: Pan Qunlong , Yu Haiming , He Xiaoyu , Weng Yiyong , Zhang Rongmou , Wang Hanshi , Li Yizhong 
Published: March 2023

ObjectiveLumbar sympathetic trunk (LST) injury is one of the major complications after oblique lumbar interbody fusion (OLIF). LST injury often manifests as unequal skin temperature in lower limbs after operation, and there may be a large number of missed diagnoses due to the lack of attention and different diagnostic methods. The study aimed to investigate the incidence and clinical characteristics of LST injury after OLIF.MethodsThe data of patients with lumbar degenerative diseases who underwent OLIF in our hospital from April 2016 to October 2017 were retrospectively analyzed. Finally, a total of 54 patients were included. There were 10 males and 44 females, aged 58.4 ± 10.9 years. The skin temperature of lower limbs was measured before and a day after surgery. The patients were followed up at 1 week, 6 weeks, 6 months, and 2 years after the surgery. Likert five‐point scale was used to evaluate the discomfort caused by LST injury. Injury severity score was introduced to grade injury degree according to the recovery time of postoperative symptoms. The chi‐square test was used to analyze the association of incidence of lumbar sympathetic trunk (LST) injury with contributing factors, such as gender and number of surgical segments.ResultsThe unequal temperature was not found before surgery in all the patients. Postoperatively, 16 cases (29.6%) had difference of skin temperature more than 0.5 °C and were diagnosed with LST injury. Eight patients (14.8%) had self‐perception of skin temperature differences, and 12 patients (22.2%) had other symptoms, such as muscle pain, numbness, and weakness, which were not statistically different between patients with and without lumbar sympathetic trunk injury (p > 0.05). In the 16 patients with LST injury, the difference of skin temperature between the two legs was 0.6 ± 0.1 °C on the first day, and the temperature difference lasted for 1.5–~12 months. According to Likert five‐point scale, two cases (12.5%) were poor, and 14 cases (87.5%) were moderate immediately after surgery. Fifteen cases improved to some extent 6 weeks to 12 months after surgery.ConclusionPostoperative LST injury is mainly manifested by different temperature of lower limbs. The incidence was higher in patients with multi‐segment OLIF than in those with single‐segment OLIF, and the subjective experience of most patients with LST injury was moderate discomfort.
Detection of cutaneous malignant melanoma by tape stripping of pigmented skin lesions – A systematic review
Authors: Thomsen Ida Marie Nedergaard , Heerfordt Ida M. , Karmisholt Katrine Elisabeth , Mogensen Mette 
Published: March 2023

AbstractBackgroundCutaneous malignant melanoma (MM) is potentially aggressive, and numerous clinically suspicious pigmented skin lesions are excised, causing unnecessary mutilation for patients at high healthcare costs, but without histopathological evidence of MM. The high number of excisions may be lowered by using more accurate diagnostics. Tape stripping (TS) of clinically suspicious lesions is a non‐invasive diagnostic test of MM that can potentially lower the number needed to biopsy/excise.Materials and methodsThe aim is to determine the diagnostic accuracy of TS in detecting MM in clinically suspicious pigmented skin lesions. This systematic review following PRISMA guidelines searched PubMed, Web of Science, and Embase (September 2022) using melanoma combined with tape stripping, adhesive patch(es), pigmented lesion assay, or epidermal genetic information retrieval.ResultsTen studies were included. Sensitivity ranged from 68.8% (95% confidence interval [CI] 51.5, 82.1) to 100% (95% CI 91.0, 100). Specificity ranged from 69.1% (95% CI 63.8, 74.0) to 100% (95% CI 78.5, 100). A pooled analysis of five studies testing the RNA markers LINC00518 and PRAME found a sensitivity of 86.9% (95% CI 81.7, 90.8) and a specificity of 82.4% (95% CI 80.8, 83.9).ConclusionOverall quality of studies was low, and the reliability of sensitivity and specificity is questionable. However, TS may supplement well‐established diagnostic methods as pooled analysis of five studies indicates a moderate sensitivity. Future studies are needed to obtain more reliable data as independent studies with no conflict of interest.