bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pre-operative MRI features predict early post-operative recurrence of hepatocellular carcinoma with different degrees of pathological differentiation
Authors: Mo Zhi-ying , Chen Pei-yin , Lin Jie , Liao Jin-yuan 
Published: February 2023

Abstract
Purpose
To investigate the value of pre-operative gadoxetate disodium (Gd-EOB-DTPA) enhanced MRI predicting early post-operative recurrence (< 2 years) of hepatocellular carcinoma (HCC) with different degrees of pathological differentiation.

Methods
Retrospective analysis of pre-operative MR imaging features of 177 patients diagnosed as suffering from HCC and that underwent radical resection. Multivariate logistic regression assessment was adopted to assess predictors for HCC recurrence with different degrees of pathological differentiation. The area under the curve (AUC) of receiver operating characteristics (ROC) was utilized to assess the diagnostic efficacy of the predictors.

Results
Among the 177 patients, 155 (87.5%) were males, 22 (12.5%) were females; the mean age was 49.97 ± 10.71 years. Among the predictors of early post-operative recurrence of highly-differentiated HCC were an unsmooth tumor margin and an incomplete/without tumor capsule (p = 0.037 and 0.033, respectively) whereas those of early post-operative recurrence of moderately-differentiated HCC were incomplete/without tumor capsule, peritumoral enhancement along with peritumoral hypointensity (p = 0.006, 0.046 and 0.004, respectively). The predictors of early post-operative recurrence of poorly-differentiated HCC were peritumoral enhancement, peritumoral hypointensity, and tumor thrombosis (p = 0.033, 0.006 and 0.021, respectively). The AUCs of the multi-predictor diagnosis of early post-operative recurrence of highly-, moderately-, and poorly-differentiated HCC were 0.841, 0.873, and 0.875, respectively. The AUCs of the multi-predictor diagnosis were each higher than for those predicted separately.

Conclusions
The imaging parameters for predicting early post-operative recurrence of HCC with different degrees of pathological differentiation were different and combining these predictors can improve the diagnostic efficacy of early post-operative HCC recurrence.
Diverse types of knowledge on a plate: a multi-perspective and multi-method approach for the transformation of urban food systems towards sustainable diets
Authors: López Cifuentes Marta , Penker Marianne , Kaufmann Lisa , Wittmann Fritz , Fiala Valentin , Gugerell Christina , Lauk Christian , Krausmann Fridolin , Eder Michael , Freyer Bernhard 
Published: February 2023

AbstractUrbanization processes are accompanied by growing global challenges for food systems. Urban actors are increasingly striving to address these challenges through a focus on sustainable diets. However, transforming food systems towards more sustainable diets is challenging and it is unclear what the local scope of action might be. Co-production of knowledge between science and non-science is particularly useful for analysing context-specific solutions and promise to result in more robust socio-economic, political and technical solutions. Thus, this paper aims to integrate different types and sources of knowledge to understand urban food systems transformation towards a more sustainable diet in Vienna; and, second, to analyse and reflect on the difficulties and ways forward to integrate diverse actors’ perspectives, multiple methods and epistemologies. We created different future scenarios that illustrate the synergies and trade-offs of various bundles of measures and the interactions among single dimensions of sustainable diets. These scenarios show that there is plenty of scope for local action, but co-ordination across diverse groups, interests, and types of knowledge is necessary to overcome lock-ins.
NLRP3 inflammasome activation By 17β-estradiol is a potential therapeutic target in hepatocellular carcinoma treatment
Authors: Awwad Sara F. , Assaf Raymonde H. , Emam Ahmed A. , Fouad Amgad A. , Arafa Lamiaa F. , El-Hanafy Aya A. 
Published: February 2023

AbstractHepatocellular carcinoma (HCC) is one of the most common cancers worldwide, and it mostly arises as a consequence of persistent chronic inflammation. Recently, NLRP3 inflammasome has caught the attention of many research groups due to its involvement in different types of cancer. However, its direct role in HCC remains elusive. Our study aimed to evaluate the role of NLRP3 inflammasome and pyroptosis in HCC and to clarify the potential mechanism by which 17β-estradiol (E2) can be used as a protective factor against HCC. NLRP3, caspase-1 (CASP1) as well as gasdermin-D (GSDMD) mRNA expression levels were assessed in human HCC tissues and adjacent non-cancerous liver tissues. Also, HepG2 HCC cells were cultured and treated with E2, followed by detection of the mRNA levels of these three genes. Our results revealed that NLRP3, CASP1, and GSDMD mRNA expressions were significantly lower in HCC tissues than in controls, and this under-expression was closely correlated with advanced HCC stages and grades. In contrast, HepG2 HCC cells displayed significantly higher expression levels of NLRP3 inflammasome components and GSDMD in the two E2-treated groups compared to the untreated group. Also, NLRP3, CASP1, and GSDMD mRNA expression levels were positively correlated with each other. This study confirmed that lack of NLRP3 inflammasome is involved in HCC progression and 17β-estradiol-induced activation of NLRP3 inflammasome may be effective in HCC treatment as it inhibited tumor cell growth and proliferation by triggering CASP1-dependent pyroptosis in HCC cells.
Ndufa4 Regulates the Proliferation and Apoptosis of Neurons via miR-145a-5p/Homer1/Ccnd2
Authors: Fu Fang , Chen Chen , Du Kun , Li Lu-shan , Li Ru , Lei Ting-ying , Deng Qiong , Wang Dan , Yu Qiu-xia , Yang Xin , Han Jin , Pan Min , Zhen Li , Zhang Li-na , Li Jian , Li Fa-tao , Zhang Yong-ling , Jing Xiang-yi , Li Fu-cheng , Li Dong-zhi , Liao Can 
Published: February 2023

AbstractThe Dandy–Walker malformation (DWM) is characterized by neuron dysregulation in embryonic development; however, the regulatory mechanisms associated with it are unclear. This study aimed to investigate the role of NADH dehydrogenase 1 alpha subcomplex 4 (NDUFA4) in regulating downstream signaling cascades and neuronal proliferation and apoptosis. Ndufa4 overexpression promoted the proliferation of neurons and inhibited their apoptosis in vitro, which underwent reverse regulation by the Ndufa4 short hairpin RNAs. Ndufa4-knockout (KO) mice showed abnormal histological alterations in the brain tissue, in addition to impaired spatial learning capacity and exploratory activity. Ndufa4 depletion altered the microRNA expressional profiles of the cerebellum: Ndufa4 inhibited miR-145a-5p expression both in the cerebellum and neurons. miR-145a-5p inhibited the proliferation of neurons and promoted their apoptosis. Ndufa4 promoted and miR-145a-5p inhibited the expression of human homer protein homolog 1 and cyclin D2 in neurons. Thus, Ndufa4 promotes the proliferation of neurons and inhibits their apoptosis by inhibiting miR-145a-5p, which directly targets and inhibits the untranslated regions of Homer1 and Ccnd2 expression.
Roles of Anatomical Abnormalities in Localized and Diffuse Chronic Rhinosinusitis
Authors: Liu Lei , Chen Qian , Pan Min , Yang Yucheng 
Published: February 2023

Abstract
Background
This study aimed to examine the roles of anatomical variation in localized and diffuse chronic rhinosinusitis [LCRS and DCRS]) .

Methods
A database was analyzed retrospectively on patients hospitalized in the Department of Otorhinolaryngology of our university hospital from 2017 to 2020. A total of 281 patients were included and divided into three categories: patients with LCRS, patients with DCRS, and a normal control group. The frequency of anatomical variation, the demographic information, disease type (with or without polyps), symptom visual analogue scale (VAS) scores and Lund-Mackay (L-M) scores were calculated and compared.

Results
Anatomical variants were observed more frequently in LCRS than DCRS (P < 0.05). The frequency of variation was higher in the LCRSwNP group than the DCRSwNP group (P < 0.05), and higher in the LCRSsNP group than the DCRSsNP group (P < 0.05). The L-M scores for patients with DCRS with nasal polyps were significantly higher (14.96 ± 6.15) than those of patients with DCRS without nasal polyps (6.80 ± 5.00) and also significantly higher (3.78 ± 2.07) than those of patients with LCRS with nasal polyps (2.63 ± 1.12; P < 0.05). A poor correlation was observed between the severity of symptoms and the performance of CT scans in CRS (R = 0.29, P < 0.01).

Conclusion
Anatomical variants were common in CRS, and possibly correlated with LCRS but not with DCRS. The frequency of anatomical variation is not associated with the occurrence of polyps. CT could reflect the severity of disease symptoms to some extent.
Knowledge, Beliefs, and Practices Towards Cochlear Implantations Among Otorhinolaryngologists in India
Authors: Ravi Rohit , Gunjawate Dhanshree R. , Bhandarkar Ajay M. , Yerraguntla Krishna 
Published: February 2023

AbstractThe outcome of the cochlear implant is dependent highly on the knowledge, belief and practice of cochlear implant in otolaryngologists who are among the important team members. The study explored the knowledge, beliefs, and practices towards cochlear implantations among otorhinolaryngologists in India. An online cross-sectional survey study was carried out using convenient sampling among otorhinolaryngologists in India. Phase-I involved developing and validating of a questionnaire to study the knowledge, beliefs, and practices towards cochlear implants among otorhinolaryngologists in India while phase II involved administration of the questionnaire and analysis. Data collection was conducted using Google Forms. A total of 106 otorhinolaryngologists participated across 24–65 years of age and with experience ranging from 1 to 42 years. The participating otorhinolaryngologists reported having good knowledge about the candidacy for a cochlear implant but having limited knowledge of the recent developments and governmental schemes. The otorhinolaryngologists displayed positive beliefs regarding cochlear implantation. Most recommended a battery of tests to determine the candidacy and gave a lot of importance to rehabilitation (96.2%) and surgery for implantation (83%). The respondents also practiced giving importance to a team approach involving multiple team members. High costs and financial burden emerged to be the major challenges for cochlear implantation in India. The findings of the survey indicate an overall positive belief and practices towards cochlear implantation by otorhinolaryngologists in India. However, there is a need to spread more awareness among them about the recent advances and schemes that would further improve their service delivery.
Isoperimetric Sets and p-Cheeger Sets are in Bijection
Authors: Caroccia Marco , Saracco Giorgio 
Published: February 2023

AbstractGiven an open, bounded, planar set $$\Omega $$
Ω
, we consider its p-Cheeger sets and its isoperimetric sets. We study the set-valued map $$\mathfrak {V}:[1/2,+\infty )\rightarrow \mathcal {P}((0,|\Omega |])$$

V
:
[
1
/
2
,
+
∞
)
→
P
(
(
0
,
|
Ω
|
]
)

associating to each p the set of volumes of p-Cheeger sets. We show that whenever $$\Omega $$
Ω
satisfies some geometric structural assumptions (convex sets are encompassed), the map is injective, and continuous in terms of $$\Gamma $$
Γ
-convergence. Moreover, when restricted to $$(1/2, 1)$$

(
1
/
2
,
1
)

such a map is univalued and is in bijection with its image. As a consequence of our analysis we derive some fine boundary regularity result.
A Pilot Study of Psychosexual Functioning and Communication in Women Treated for Advanced Stages of Cervical Cancer After the Diagnosis
Authors: Liberacka-Dwojak Magdalena , Wiłkość-Dębczyńska Monika , Ziółkowski Szymon 
Published: February 2023

Abstract
Introduction
The purpose of this pilot study was to examine relationships between body image, perceived stress, partner and patient-provider sexual communication, and sexual functioning in women with advanced stages of cervical cancer (CC) after the cancer diagnosis.

Methods
In this pilot study, cancer patients (n = 30) and healthy women (n = 30) were compared. A study was conducted from January to March 2022. Sexual functioning and its predictors were assessed using the 6-item Female Sexual Function Index (FSFI-6), the Perceived Stress Scale (PSS-10), the Sexual Communication Self-Efficacy Scale (SCSES), the self-administered questionnaire contributing the patient-provider sexual communication, and the Body Esteem Scale (BES). The data was collected from January to June 2022.

Results
Women with cervical cancer after the diagnosis reported impaired sexual functioning, which was associated with self-efficacy in sexual communication, feeling comfortable discussing sexual issues with a healthcare provider, perceived stress, and body image. Compared to the control group, CC patients had significantly lower sexual functioning (mean 8.83 vs 19.23; p < 0.001).

Conclusions
Sexual functioning in women with CC is significantly impaired even after the diagnosis and is associated with psychosocial variables. The expanded study will include other predictors of sexual functioning and quality of life in women with CC on the larger group of patients.

Policy Implications
As cancer becomes a more chronic disease that affects even younger individuals, social policy should promote the sexuality issues in cancer patients, as it is an integral part of every person’s life, regardless of health status or age.
A Qualitative Study of 11 World-Class Team-Sport Athletes’ Experiences Answering Subjective Questionnaires: A Key Ingredient for ‘Visible’ Health and Performance Monitoring?
Authors: McCall Alan , Wolfberg Adrian , Ivarsson Andreas , Dupont Gregory , Larocque Amelie , Bilsborough Johann 
Published: February 2023

Abstract
Background
Athlete monitoring trends appear to be favouring objective over subjective measures. One reason of potentially several is that subjective monitoring affords athletes to give dishonest responses. Indeed, athletes have never been systematically researched to understand why they are honest or not.

Objective
Because we do not know what motivates professional athletes to be honest or not when responding to subjective monitoring, our objective is to explore the motives for why the athlete may or may not respond honestly.

Methods
A qualitative and phenomenological approach was used, interviewing 11 world-class team-sport athletes (five women, six men) about their experiences when asked to respond to subjective monitoring questionnaires. Interview transcripts were read in full and significant quotations/statements extracted. Meanings were formulated for each interviewees’ story and assigned codes. Codes were reflected upon and labelled as categories, with similar categories grouped into an overall theme. Themes were examined, articulated, re-interpreted, re-formulated, and written as a thematic story, drawing on elements reported from different athletes creating a blended story, allowing readers a feel for what it is like to live the experience.

Results
Overall, four key themes emerged: (i) pursuit of the ideal-self, (ii) individual barriers to athlete engagement, (iii) social facilitators to athlete engagement; and (iv) feeling compassion from performance staff.

Conclusions
Our main insight is that athletes’ emotions play a major role in whether they respond honestly or not, with these emotions being driven at least in part by the performance staff asking the questions.
Frequency evaluation for adapted peer methods
Authors: Conte Dajana , Moradi Leila , Paternoster Beatrice 
Published: February 2023

AbstractIn this paper, we consider exponentially fitted peer methods for the numerical solution of first order differential equations and we investigate how the frequencies can be tuned in order to obtain the maximal benefit. We will show that the key is analyzing the error’s behavior. Formulae for optimal frequencies are computed. Numerical experiments show the properties of the proposed algorithm.
Are glucose and insulin levels at all time points during OGTT a reliable marker of diabetes mellitus risk in pediatric obesity?
Authors: La Valle A. , d’Annunzio G. , Campanello C. , Tantari G. , Pistorio A. , Napoli F. , Patti G. , Crocco M. , Bassi M. , Minuto N. , Piccolo G. , Maghnie M. 
Published: February 2023

Abstract
Purpose
Childhood overweight and obesity associated with insulin resistance and metabolic syndrome represent the new global pandemic and the main causative factors for dysglycemia, prediabetes, and Type 2 Diabetes Mellitus (T2DM). Predictors, such as HOMA-IR, HOMA-β%, and QUICKI lack specific reference values in children. OGTT is a gold standard for glycometabolic assessment. Recently, a glycemic level higher than 155 mg/dl at + 60′ after glucose ingestion has been defined as a risk factor for T2DM in obese adolescents. We aim to analyze and correlate fasting insulin-resistance markers with OGTT results in overweight/obese children and adolescents.

Methods
We retrospectively evaluated glucose and insulin values during a 2-h OGTT every 30 min in 236 overweight/obese patients. Glucose values and insulin sum during OGTT were compared to glycometabolic indexes and different cut-off values for insulin sum.

Results
A 1-h glucose > 155 mg/dl and insulin sum > 535 microU/ml at all times during OGTT are the best predictors of diabetes risk in obese youths. A1-h glucose > 155 mg/dl is significantly associated with HbA1c > 5.7%, while no association was observed between HbA1c > 5.7% and glucose levels at baseline and 2 h. The ability of the standardized HOMA-IR to predict the prediabetes status is clearly lower than the total insulin sum at OGTT.

Conclusion
Our study demonstrates that also 1-h post-OGTT glucose, together with HbA1c, is an effective diabetes predictor.
Simulating daily sediment transport using the Water Quality and Sediment Model (WQSED)
Authors: Gwapedza David , Hughes Denis Arthur , Slaughter Andrew Robert , Mantel Sukhmani Kaur 
Published: February 2023

Abstract
Introduction
High erosion and sediment yield rates continue to pose a significant threat to the environment globally. Information on erosion and sediment rates is key for supporting effective and sustainable mitigation measures. Models that estimate sediment yield are vital in providing information about erosion and sediment yield rates, as empirical studies are prohibitive over large spatial and temporal scales.

Methods
In this study, we simulate daily sediment transport using the WQSED model and assess the effectiveness of the tool in providing crucial estimations of sediment yield. The model structure links the Modified Universal Soil Loss Equation (MUSLE) to a simple sediment storage component. The model was applied to the Odzi River catchment in Zimbabwe and The Rio Tanama River catchment in Puerto Rico, where daily observations of sediment yield exceeding a decade were available for calibration and validation.

Results
In both catchments, we achieved a coefficient of efficiency and R2 and NSE of > 0.7 during model calibration and > 0.6 during model validation. The percentage bias remained below 45% for both calibration and validation periods.

Conclusion
These results indicate that the WQSED model can be applied to provide estimates of sediment yield that are reliable for erosion, sediment yield and water quality management. An effective and relatively simple sediment yield model incorporating sediment storage is essential for catchment management in erosion-prone areas.
What Emotions to Encourage? The Role of High and Low Arousal Positive Emotions in Three Randomized Controlled Trials of Different Positive Psychology Interventions
Authors: Kraiss Jannis T. , Bohlmeijer Ernst T. , Schotanus-Dijkstra Marijke 
Published: February 2023

AbstractGrowing evidence shows that positive psychology interventions (PPIs) are able to enhance positive emotions. However, less is known about the specific role of high and low arousal positive emotions within such interventions. The goal of the current study is to examine the effect of different types of PPIs on high and low arousal emotions and to explore whether high and low arousal positive emotions serve as mediators for the intervention effects on mental well-being. Post-hoc tests of three formerly published randomized controlled trials were conducted in comparison with waitlist control: (1) a multicomponent PPI (N = 275), (2) a comprehensive gratitude intervention (N = 144), and (3) an acts of kindness intervention (N = 216). Findings showed that the multicomponent PPI improved low arousal emotions, while the gratitude intervention marginally improved high arousal positive emotions. The acts of kindness intervention was not more effective in improving positive emotions compared to waitlist control. Similar conclusions could be drawn from the mediation analyses, yielding most pronounced results for low arousal positive emotions mediating the effect of the multicomponent PPI on mental well-being. The current study provides first evidence that the upward spiral of positive emotions might depend on the type of PPI and its impact on high and in particular low arousal positive emotions.
A Holistic Workflow for Semi-automated Object Extraction from Large-Scale Historical Maps
Authors: Schlegel Inga 
Published: February 2023

AbstractThe extraction of objects from large-scale historical maps has been examined in several studies. With the aim to research urban changes over time, semi-automated and transferable holistic approaches remain to be investigated. We apply a combination of object-based image analysis and vectorization methods on three different historical maps. By further matching and georeferencing an appropriate current geodataset, we provide a concept for analyzing and comparing those valuable sources from the past. With minor adjustments, our end-to-end workflow was transferable to other large-scale maps. The findings revealed that the extraction and spatial assignment of objects, such as buildings or roads, enable the comparison of maps from different times and form a basis for further historical analysis. Performing an affine transformation between the datasets, an absolute offset of no more than 72 m was achieved. The outcomes of this paper, therefore, facilitate the daily work of urban researchers or historians. However, it should be emphasized that specific knowledge is required for the presented subjective methodology.