bluuebunny/crossref_metadata_2025_split huggingface dataset:
Financial Performance Evaluating and Ranking Approach for Banks in Bist Sustainability Index Using Topsis and K-Means Clustering Method
Authors: Özari Çiğdem , Can Esin Nesrin 
Published: January 2023

The purpose of this study is to identify, analyze, and evaluate the differences between banks in the Borsa İstanbul (BIST) Sustainability Index and other banks based on their financial performance. This study employs an approach based on a technique for order of preference by similarity to an ideal solution to evaluate and rank 46 Turkish banks with an evaluation framework consisting of 11 financial ratios between 2015 and 2019. The entropy, equal weight, standard, and variance methods were adapted to determine the weights of the financial ratios. Ultimately, the closeness coefficients of the banks derived from the four different weighted TOPSIS methods assist in identifying the positions of banks within other banks using K-means clustering analysis. However, this analysis has two main drawbacks. One is to determine the value of k and the other is to select the initial centers. The Calinski-Harabsz Index (CHI) was used to determine the validity of k. To solve the initial center drawback, we ran the clustering algorithm for all combinations of initial centers from the dataset. CHI is again used to determine which cluster group, derived from a different initial center, is more accurate. Finally, we present the results obtained by using this process for a set of 46 banks.

Received: 20 September 2022 / Accepted: 26 December 2022 / Published: 5 January 2023
The Role of Mediation Barriers to Self-Efficacy in Improving Hospital Revisitation: Empirical Evidence in the Healthcare Industry in Indonesia
Authors: Andry . , Ewaldo . , Adhikara Arrozi , Kusumapradja Rokiah , Handayani Sri 
Published: January 2023

This research aims to determine the role of barriers to self-efficacy as mediation on the repeat visits by patients in the National Health Insurance (JKN) at Advanced Referral Health Facilities (FKRTL) Class C in Indonesia. This is an explanatory causality research with the purposive sampling method used to collect data from a cross-sectional survey of 225 patients of class C FKRLT in Jakarta, Bogor, Depok, and Bekasi using a questionnaire. The data collected were analyzed using structural equation modelling (SEM). The results showed that brand image and perception of patient-centered services positively affect barriers to self-efficacy and are a mediator to increasing patient return visits. These findings are helpful for stakeholders to make decisions in improving patient-centered regulations and service standards for the realization of hospital sustainability, good governance, and effective strategies to retain BPJS patients.

Received: 17 October 2022 / Accepted: 29 December 2022 / Published: 5 January 2023
Analisis Pelaksanaan Program Pelayanan Nomor Tunggal Panggilan Darurat Muba Siaga 112 di Dinas Komunikasi dan Informatika Kabupaten Musi Banyuasin
Authors: S Rayani V , Mudasir Mudasir , Saswita Saswita 
Published: January 2023

Layanan Nomor Tunggal Panggilan Darurat Muba Siaga 112 diselenggarakan oleh Pemerintah Kabupaten Musi Banyuasin dimana yang menjadi Pusat Panggilan Kedaruratan yaitu Dinas Komunikasi dan Informatika Kabupaten Musi Banyuasin. Dengan adanya Program Pelayanan Nomor Tunggal Panggilan Darurat Muba Siaga 112 ini, diharapkan dapat memudahkan masyarakat di Lingkunga Kabupaten Musi Banyuasin untuk menerima layanan kedaruratan dengan mudah dan cepat tanggap. Tujuan penelitian ini adalah untuk menganalisis Pelaksanaan Program Pelayanan Nomor Tunggal Panggilan Darurat Muba Siaga 112 di Dinas Komunikasi dan Informatika Kabupaten Musi Banyuasin. Teknik analisis yang digunakan dalam penelitian ini adalah teknik analisis data kualitatif. Penelitian ini menunjukkan bahwa secara keseluruhan Pelaksanaan Program Pelayanan Nomor Tunggal Panggilan Darurat Muba Siaga 112 di Dinas Komunikasi dan Informatika Kabupaten Musi Banyuasin belum dilaksanakan secara optimal. Hal ini disebabkan karena adanya kendala atau masalah di dalamnya. Masalah dalam penelitian ini yaitu dalam pelaksanaan pelayanan kedaruratan masih kurangnya sarana dan prasarana pendukung serta sosialisasi tentang layanan kedaruratan Muba Siaga 112 yang masih kurang. Selanjutnya, Pemerintah Daerah Kabupaten Musi Banyuasin khususnya Dinas Komunikasi dan Informatika Kabupaten Musi Banyuasin diharapkan dapat mencari solusi yang tepat untuk mengatasi permasalahan yang menjadi kendala atau masalah dalam pelaksanaan pelayanan sehingga dapat terciptanya pelayanan yang prima yakni cepat, tepat, mudah dan ramah.
Implementasi Kebijakan Pencegahan Penyebaran Corona Virus Desease 19 di Badan Perencanaan Pembangunan Daerah Provinsi Sumatera Selatan
Authors: Widiastuty Ika , Syuroh Mat , Nasyaya Annada 
Published: January 2023

Provinsi Sumatera Selatan merupakan salah satu provinsi yang terus berusaha melakukan pencegahan penyebaran Corona Virus Desease 19 di Lingkungan Pemerintah Daerah Provinsi Sumatera Selatan yaitu dengan cara menindaklanjuti Surat Edaran Menteri Pendayagunaan Aparatur Negara dan Reformasi Birokrasi Nomor 67 Tahun 2020 tanggal 4 September 2020 tentang Perubahan Surat Edaran Menteri Pendayagunaan Aparatur Negara dan Reformasi Birokrasi Nomor 58 Tahun 2020 tentang Sistem Kerja Pegawai Aparatur Sipil Negara dalam Tatanan Normal Baru. Adapun tujuan dari penelitian ini yaitu untuk mengetahui Implementasi Kebijakan Pencegahan Penyebaran Corona Virus Desease 19 di Badan Perencanaan Pembangunan Daerah Provinsi Sumatera Selatan. Hal yang diidentifikasikan yaitu: Komunikasi masih dilakukan satu arah yang berdampak pada: Gaya komunikator yang mengendalikan/ otoriter yang menggunakan jenis komunikasi lisan sifatnya satu arah (vertikal) sehingga atasan sulit untuk menerima keluhan, saran, dan tanggapan dari bawahan secara langsung serta Tanggapan dari bawahan/ komunikan sulit diketahui oleh atasan karena dalam bentuk komunikasi tulisan yang berupa laporan bulanan, laporan tahunan, rencana kerja dan sasaran/ target kerja karena harus dibaca, diteliti dan dipelajari terlebih dahulu agar mudah dimengerti serta Masih ada pegawai yang belum mentaati peraturan mengenai Kebijakan Pencegahan Penyebaran Corona Virus Desease 19 di Badan Perencanaan Pembangunan Daerah Provinsi Sumatera Selatan tahun 2020. Teknik analisis data yang digunakan dalam penelitian ini adalah teknik analisis data kualitatif. Penelitian ini menunjukkan bahwa: secara keseluruhan Implementasi Kebijakan Pencegahan Penyebaran Corona Virus Desease 19 di Badan Perencanaan Pembangunan Daerah Provinsi Sumatera Selatan, dapat disimpulkan bahwa secara keseluruhan Implementasi Kebijakan Pencegahan Penyebaran Corona Virus Desease 19 di Badan Perencanaan Pembangunan Daerah Provinsi Sumatera Selatan sudah dilaksanakan sesuai dengan Surat Edaran Gubernur Sumatera Selatan Nomor 800/1492/BKD.l/2020 tentang Sistem Kerja Aparatur Sipil Negara Dalam Tatanan Normal Baru di Lingkungan Pemerintah Provinsi Sumatera Selatan, walaupun dari segi komunikasi, dan mekanisme/ prosedur masih mengalami sedikit hambatan. Seperti 1) Komunikasi masih dilakukan satu arah. 2) Masih ada pegawai yang belum mentaati peraturan mengenai Kebijakan Pencegahan Penyebaran Corona Virus Desease 19 di Badan Perencanaan Pembangunan Daerah Provinsi Sumatera Selatan tahun 2020.
Analisa Dampak Kebijakan Corona Virus Desease 2019 Terhadap Operasional Bus di Kabupaten Ogan Komering Ulu
Authors: Rohilza Octa Diaz , Idi Abdullah , Sutinah Sutinah 
Published: January 2023

Penelitian dengan judul Dampak Kebijakan Covid-19 Terhadap Operasional Bus di Kabupaten Ogan Komering Ulu bertujuan untuk mengetahui keefetivitasan penyidikan tindak pidana narkoba dan obat-obat berbahaya. Penelitian ini menggunakan pendekatan kualitatif, yaitu suatu tata cara penelitian yang bertujuan menggambarkan mengenai keadaaan tertentu, yang digambarkan dengan kata-kata atau kalimat terpisah-pisah untuk memperoleh kesimpulan. Fokus penelitian dalam penelitian ini adalah Dampak Kebijakan Covid-19 Terhadap Operasional Bus di Kabupaten Ogan Komering Ulu. Teknik analisis data yang digunakan yaitu teknik analisis data kualitatif, sedangkan teknik pengumpulan data yang digunakan yaitu observasi, wawancara dan dokumentasi. Hasil penelitian dengan menggunakan 3 dimensi efektifitas menurut (sterrs,2005) menunjukkan dari dimensi Input : Adanya kerjasama yang baik antara petugas dan masyarakat sehingga pada penilaian efektivitas sangat baik dirasakan dengan adanya komunikasi yang baik antara petugas dan masyarakat melalui pelaporan kasus. Dimensi Proses : adanya pengorganisasian tim dan anggota yang kompeten sehingga perencanaan dalam melakukan tindakan dapat berjalan dengan lancar, sesuai dengan standar operasional prosedur yang berlaku pada penyidikan. Sedangkan dimensi Output : dengan bertambahnya kasus di Sumatera Selatan terkait tindak pidana narkoba dan obat-obatan berbahaya, memberikan tugas yang lebih dan serius kepada instansi untuk dapat terus melakukan pengembangan dan evaluasi terhadap penyelesaian kasus narkoba dan obat-obatan berbahaya dengan pengawasan, pengendalian serta evaluasi yang dapat dilakukan secara berkala dan berjenjang setiap bulan.
A Catalog of Habitable Zone Exoplanets
Authors: Hill Michelle L. , Bott Kimberly , Dalba Paul A. , Fetherolf Tara , Kane Stephen R. , Kopparapu Ravi , Li Zhexing , Ostberg Colby 
Published: January 2023

Abstract
The search for habitable planets has revealed many planets that can vary greatly from an Earth analog environment. These include highly eccentric orbits, giant planets, different bulk densities, relatively active stars, and evolved stars. This work catalogs all planets found to reside in the habitable zone (HZ) and provides HZ boundaries, orbit characterization, and the potential for spectroscopic follow-up observations. Demographics of the HZ planets are compared with a full catalog of exoplanets. Extreme planets within the HZ are highlighted, and how their unique properties may affect their potential habitability is discussed. Kepler-296 f is the most eccentric ≤2 R
⊕ planet that spends 100% of its orbit in the HZ. HD 106270 b and HD 38529 c are the most massive planets (≤13 M
J) that orbit within the HZ, and are ideal targets for determining the properties of potential hosts of HZ exomoons. These planets, along with the others highlighted, will serve as special edge cases to the Earth-based scenario, and observations of these targets will help test the resilience of habitability outside the standard model. The most promising observational HZ target that is known to transit is GJ 414 A b. Of the transiting, ≤2 R
⊕ HZ planets, LHS 1140 b, TRAPPIST-1 d, and K2-3 d are the most favorable. Of the nontransiting HZ planets, HD 102365 b and 55 Cnc f are the most promising, and the best nontransiting candidates that have ≤2 R
⊕ are GJ 667 C c, Wolf 1061 c, Ross 508 b, Teegarden’s Star b, and Proxima Cen b.
Group 2 Innate Lymphoid Cells Are Detrimental to the Control of Infection with Francisella tularensis
Authors: Dow Joshua , Cytlak Urszula M , Casulli Joshua , McEntee Craig P , Smedley Catherine , Hodge Suzanne H , D’Elia Riccardo V , Hepworth Matthew R , Travis Mark A 
Published: January 2023

Abstract
Innate lymphoid cells (ILCs) are capable of rapid response to a wide variety of immune challenges, including various respiratory pathogens. Despite this, their role in the immune response against the lethal intracellular bacterium Francisella tularensis is not yet known. In this study, we demonstrate that infection of the airways with F. tularensis results in a significant reduction in lung type 2 ILCs (ILC2s) in mice. Conversely, the expansion of ILC2s via treatment with the cytokine IL-33, or by adoptive transfer of ILC2s, resulted in significantly enhanced bacterial burdens in the lung, liver, and spleen, suggesting that ILC2s may favor severe infection. Indeed, specific reduction of ILC2s in a transgenic mouse model results in a reduction in lung bacterial burden. Using an in vitro culture system, we show that IFN-γ from the live vaccine strain–infected lung reduces ILC2 numbers, suggesting that this cytokine in the lung environment is mechanistically important in reducing ILC2 numbers during infection. Finally, we show Ab-mediated blockade of IL-5, of which ILC2s are a major innate source, reduces bacterial burden postinfection, suggesting that IL-5 production by ILC2s may play a role in limiting protective immunity. Thus, overall, we highlight a negative role for ILC2s in the control of infection with F. tularensis. Our work therefore highlights the role of ILC2s in determining the severity of potentially fatal airway infections and raises the possibility of interventions targeting innate immunity during infection with F. tularensis to benefit the host.
Apoptosis Inhibitor of Macrophages Contributes to the Chronicity of Mycobacterium avium Infection by Promoting Foamy Macrophage Formation
Authors: Kajiwara Chiaki , Shiozawa Ayako , Urabe Naohisa , Yamaguchi Tetsuo , Kimura Soichiro , Akasaka Yoshikiyo , Ishii Yoshikazu , Tateda Kazuhiro 
Published: January 2023

Abstract
In Mycobacterium avium infections, macrophages play a critical role in the host defense response. Apoptosis inhibitor of macrophage (AIM), also known as CD5L, may represent a novel supportive therapy against various diseases, including metabolic syndrome and infectious diseases. The mechanisms of AIM include modulating lipid metabolism in macrophages and other host cells. We investigated the role of AIM in M. avium infections in vitro and in vivo. In a mouse model of M. avium pneumonia, foamy macrophages were induced 6 wk after infection. The bacteria localized in these macrophages. Flow cytometric analysis also confirmed that the percentage of CD11chighMHCclassIIhigh interstitial and alveolar macrophages, a cell surface marker defined as foamy macrophages, increased significantly after infection. AIM in alveolar lavage fluid and serum gradually increased after infection. Administration of recombinant AIM significantly increased the number of bacteria in the lungs of mice, accompanied by the induction of inflammatory cytokine and iNOS expression. In mouse bone marrow–derived macrophages, the mRNA expression of AIM after M. avium infection and the amount of AIM in the supernatant increased prior to the increase in intracellular bacteria. Infected cells treated with anti-AIM Abs had fewer bacteria and a higher percentage of apoptosis-positive cells than infected cells treated with isotype control Abs. Finally, AIM in the sera of patients with M. avium-pulmonary disease was measured and was significantly higher than in healthy volunteers. This suggests that AIM production is enhanced in M. avium–infected macrophages, increasing macrophage resistance to apoptosis and providing a possible site for bacterial growth.
African Swine Fever Virus E184L Protein Interacts with Innate Immune Adaptor STING to Block IFN Production for Viral Replication and Pathogenesis
Authors: Zhu Zixiang , Li Shasha , Ma Caina , Yang Fan , Cao Weijun , Liu Huanan , Chen Xia , Feng Tao , Shi Zhengwang , Tian Hong , Zhang Keshan , Chen Hongjun , Liu Xiangtao , Zheng Haixue 
Published: January 2023

Abstract
African swine fever is one of the most serious viral diseases that affects domestic and wild pigs. The causative agent, African swine fever virus (ASFV), has evolved sophisticated immune evasion mechanisms that target both innate and adaptive immune responses. However, the underlying molecular mechanisms have not been fully understood. Here, we report that ASFV E184L protein inhibits host innate immune response via targeting the stimulator of IFN genes (STING)-mediated signaling pathway in both human embryonic kidney HEK-293T cells and porcine pulmonary alveolar macrophages. E184L interacts with STING, impairing dimerization and oligomerization of STING but not affecting its puncta formation at the perinuclear region. Furthermore, E184L disrupts STING-TBK1-IRF3 complex formation, leading to inhibition of STING phosphorylation, and IRF3 dimerization and nuclear translocation. The 1–20 aa region in E184L is essential for E184L-STING interaction and blocking IL-1β and type I IFN production. Deletion of E184L in ASFV considerably impairs antagonistic function of the virus in suppression of the STING-mediated antiviral response, an effect that is reversible by introduction of E184L. Importantly, the virulence of mutant ASFV lacking E184L is reduced in pigs compared with its parental virus due to induction of higher IFN production in vivo. Our findings indicate that ASFV E184L is an important antagonist of IFN signaling to evade host innate immune antiviral responses, which improves our understanding of immune evasion mechanisms of ASFV.
A Novel TrxR1 Inhibitor Regulates NK and CD8+ T Cell Infiltration and Cytotoxicity, Enhancing the Efficacy of Anti–PD-1 Immunotherapy against Hepatocarcinoma
Authors: Su Xiaoxia , Yin Hanwei , Bai Man , Liu Jiayi , Liu Runyu , Zeng Huihui , Wen Jinhua 
Published: January 2023

Abstract
Hepatocellular carcinoma (HCC) has the third highest cancer-related mortality rate globally. The immunosuppressive microenvironment of HCC limits effective treatment options. HCC cells and associated microenvironmental factors suppress NK and T cell infiltration and cytotoxic activities. The abnormal number or function of NK and T cells leads to a lack of immune surveillance. Recently, immunotherapy targeting PD-1 and PD-L1 has been shown to activate functionally exhausted cytotoxic immune cells in some solid tumors. However, the response rate and therapeutic efficacy against solid tumors with little lymphocyte infiltration are limited, especially for HCC. Therefore, new targets and therapeutics that induce tumor cell apoptosis and overcome the problem of depletion of immune cells, thereby inhibiting the immune escape of HCC cells, are urgently required. Butaselen (2-bis[2-(1,2-benzisothiazol-2(2H)-ketone)]butane), an organic molecule containing selenium, is a new type of thioredoxin reductase inhibitor. In this study, we found that butaselen promoted NK and T cell activity and infiltration in the tumor microenvironment in HCC-bearing mice by enhancing the expression of CXCR3, NKG2D, and their respective ligands. When used alone, it can significantly inhibit tumor growth and exert a synergistic effect in combination with PD-1 blockade. We suggested the role of the thioredoxin reductase system in the regulation of the tumor immunosuppressive microenvironment and developed a new effective therapeutic molecule for HCC, revealing the mechanism of butaselen in inhibiting tumor cell immune escape.
Complete Tolerogenic Adjuvant Stimulates Regulatory T Cell Response to Immunization
Authors: Zheng Guoxing , Geng Yajun , Yan Zhaoqi , Shin Soo Min , Joshi Kanak , Panicker Anjali , Shankar Archana , Elangovan Ramya , Koehler Jason , Gnanasekar Varun , Gilles Jessica Ann , Munirathinam Gnanasekar , Chen Aoshuang 
Published: January 2023

Abstract
We have determined in mice the minimum composition required for forming a vaccine adjuvant that stimulates a regulatory T (Treg) cell response to immunization, and we named the adjuvant “complete tolerogenic adjuvant.” This new kind of adjuvant may let us use the well-proven “Ag with adjuvant” form of immunization for inducing Treg cell–mediated Ag-specific immunosuppression. The minimum composition consists of dexamethasone, rapamycin, and monophosphoryl lipid A at a mass ratio of 8:20:3. By dissecting the respective role of each of these components during immunization, we have further shown why immunosuppressive and immunogenic agents are both needed for forming true adjuvants for Treg cells. This finding may guide the design of additional, and potentially more potent, complete tolerogenic adjuvants with which we may form numerous novel vaccines for treating immune diseases.
Determination of the repeatability of corneal densitometry as measured with a Scheimpflug camera device in refractive surgery candidates
Authors: Balparda Kepa , Mesa-Mesa Sara , Maya-Naranjo Maria Isabel , Mora-Sánchez Carolina , Escobar-Giraldo Mariana 
Published: January 2023

Purpose:
Corneal densitometry analysis provides an objective measurement of corneal transparency in patients undergoing photorefractive keratectomy (PRK). To date, no study that focuses on determining the reliability and smallest real difference (SRD), specifically in PRK candidates, has been published.

Methods:
The study was conducted at Clínica de Oftalmología Sandiego, Medellín, Colombia. This was a prospective and analytical study. Refractive surgery candidates underwent Pentacam measurements twice with five minutes of difference. Repeatability of measurements was evaluated for every area using Wilcoxon signed-rank test, Spearman’s rank-order correlation, and the intraclass correlation coefficient, followed by a within-subjects factor (Sw) finishing with a determination of the SRD for all areas. Bland–Altman plots were created and analyzed.

Results:
A total of 110 eyes were included. The mean total densitometry was 18.67 ± 1.56 grayscale units (GSU) and 18.65 ± 1.49 GSU for the first and second measurements, respectively. Wilcoxon was non-significant (P > 0.05) while the intraclass correlation coefficient demonstrated an excellent agreement. SRD ranged from 0.21 GSU (posterior × 6–10 mm) to 1.79 GSU (total × 10–12 mm). Anterior depths and 10–12 mm annulus had consistently more variability and greater (worse) SRD. The 10–12 mm annulus showed great dispersion on the Bland–Altman plots.

Conclusion:
Corneal densitometry has an excellent repeatability in refractive surgery candidates for areas below 10 mm. Any densitometry change ≥1.0 GSU in areas under 10 mm should be considered as well above measurement noise and corresponding to a real change in measured parameters. The 10–12 mm area does not seem to be reliable enough in refractive surgery candidates to warrant surveillance after corneal-based surgery.
Short-term outcomes of micropulse transscleral cyclophotocoagulation as a primary versus additional therapy in eyes with uncontrolled glaucoma
Authors: Rajendrababu Sharmila , Senthilkumar Vijayalakshmi A , Tara Techi Dodum , Uduman Mohammed Sithiq , Aila Laxmi Ananya , Shukla Aakriti Garg 
Published: January 2023

Purpose:
To study the safety and efficacy outcomes of Micropulse Transscleral Cyclophotocoagulation (MP-TSCPC) as a primary versus additional therapy in eyes with uncontrolled glaucoma.

Methods:
This was a prospective, interventional, comparative study. All patients with advanced and refractory glaucoma treated with MP-TSCPC from April 2020 to December 2020 were recruited in this study.

Results:
A total of 77 eyes of 77 patients were analyzed. Group A (n = 33), included patients with advanced glaucoma at high risk for invasive surgery, who underwent MP-TSCPC as the primary intervention, and group B (n = 44) included patients who had undergone previous surgical intervention and MP-TSCPC was used additionally to control the intraocular pressure (IOP). Mean IOP and mean number of antiglaucoma medications were 34.06 (13.9) mmHg and 3.64 (0.7), respectively, in group A and 35.61 (11.5) mmHg and 3.73 (0.9), respectively, in Group B. Postoperatively, the mean IOP and percentage of IOP reduction were significantly lower at 1, 3, and 6 months, that is, 20.78 (32%), 22.07 (30%), and 19.09 (37%), respectively, in group A and 23.68 (35%), 19.50 (44%), and 19.61 (42%), respectively, in group B, but there was no difference between the groups at all visits. Postoperative need for ocular hypotensive drugs did not differ in group A (P = 0.231); however, it was significantly lower in group B (P = 0.027). Group A had 87%, 77%, and 74% success rates at 1, 3, and 6 months, respectively, whereas group B had 91%, 86%, and 77% success rates at 1, 3, and 6 months, respectively. Postoperative complications and intervention did not reveal any statistical difference between the two groups.

Conclusion:
MP-TSCPC may be considered as a temporizing measure both as a primary or as an additional intervention to control the IOP in eyes with refractory and advanced glaucoma that have a high risk of vision-threatening complications with invasive surgery.