bluuebunny/crossref_metadata_2025_split huggingface dataset:
Real-time mechanism-based interventions for daily alcohol challenges: Protocol for ecological momentary assessment and intervention
Authors: Liu Shuyan , Haucke Matthias , Groß Rika , Schneider Kay , Shin Jaekyung , Arntz Fabian , Bach Patrick , Banaschewski Tobias , Beste Christian , Deserno Lorenz , Ebner-Priemer Ulrich , Endrass Tanja , Ganz Marvin , Ghadami Ali , Giurgiu Marco , Heinz Andreas , Kiefer Falk , Kliegl Reinhold , Lenz Bernd , Marciniak Marta Anna , Meyer-Lindenberg Andreas , Neubauer Andreas B. , Rapp Michael , Smolka Michael N. , Strehle Jens , Spanagel Rainer , Spitta Gianna , Tost Heike , Walter Henrik , Zech Hilmar , Reichert Dominic , Reichert Markus 
Published: January 2025

Background Advancing evidence-based, tailored interventions for substance use disorders (SUDs) requires understanding temporal directionality while upholding ecological validity. Previous studies identified loneliness and craving as pivotal factors associated with alcohol consumption, yet the precise directionality of these relationships remains ambiguous. Objective This study aims to establish a smartphone-based real-life intervention platform that integrates momentary assessment and intervention into everyday life. The platform will explore the temporal directionality of contextual influences on alcohol use among individuals experiencing loneliness and craving. Methods We will target 180 individuals aged 18 to 70 in Germany who report loneliness, alcohol cravings, and meet risk or binge drinking criteria (over 14 standard drinks per week or five drinks in a single day for males, and over seven drinks per week or four drinks in a single day for females). Using a Within-Person-Encouragement-Design and Just-In-Time-Adaptive-Interventions, we will manipulate the contexts of loneliness and alcohol craving with cognitive reappraisal and physical activity interventions against a control condition (working memory task). Results Recruitment started in June 2024, with data collection and processing expected by June 2027. Conclusion Our real-life intervention platform endeavors to serve as a robust tool for discerning the directionality of the effects from time series data in everyday life influences on alcohol use for the future study. Ultimately, it will pave the way for low-threshold prevention, clinical treatment, and therapy to target diverse contexts of everyday life in SUD. Trial registration German Clinical Trials Register DRKS00033133.
Social media activism and women's health: Endometriosis awareness and support
Authors: Seo Hyunjin , Burkett K. Macy , Okocha Moses , Ha Huong , Chaif Rim , Izhar Nazra , Coelho Michaella Barros , Jona Blessing , Iqbal Azhar 
Published: January 2025

Objective While endometriosis is estimated to affect 1 in 10 women globally, awareness of the disease as well as research and funding to fight the disease remains lacking as compared with other chronic diseases. This study examines how social media users utilized Instagram to raise awareness of and mobilize activism around endometriosis by analyzing prominent topics, word associations, and feminism themes in endometriosis-tagged posts on Instagram. Methods We used a mixed-method approach of combining computational analyses (topic modeling and word association) and human coding (qualitative thematic analysis) of Instagram posts on endometriosis. Results Our results show that while Instagram users discussed a variety of issues related to the disease on the social media platform, these issues tend to focus on four topic areas: (i) living with endometriosis, (ii) pregnancy and endometriosis, (iii) awareness and empowerment, and (iv) women's health and wellbeing. In addition, social media users widely incorporated three feminism themes: (i) bringing attention to invisible disability, (ii) solidarity and support among women, and (iii) advocacy and activism around women's health. Conclusion People with endometriosis use Instagram to create an online public sphere for raising awareness of the disease, offering networking and support to other endometriosis patients, and creating a movement for enhancing women's health and wellness. In doing so, they are also addressing sexism and misconceptions about endometriosis that have traditionally contributed to normalizing women's experience of pain associated with endometriosis and consequently delaying endometriosis diagnoses.
Arthroscopic Bone Grafting of Deep Acetabular Cysts in Hip Preservation Surgery: A Matched Case-Control Study
Authors: Marty Eric W. , Girardi Nicholas G. , Kraeutler Matthew J. , Lee Jessica H. , Keeter Carson , Merkle Alexander N. , Mei-Dan Omer 
Published: January 2025

Background: Acetabular subchondral cysts are commonly identified signs of joint degeneration and arthritis. This pathology is generally considered a relative contraindication for hip preservation surgery. Purpose: To investigate the effect of arthroscopic bone grafting for the treatment of acetabular subchondral cysts. Study Design: Cohort study (diagnosis); Level of evidence, 3. Methods: We completed a retrospective analysis of hip arthroscopies performed by the senior author between 2013 and 2021. Patients with radiologic evidence of acetabular cysts who underwent arthroscopic bone grafting, with or without subsequent periacetabular osteotomy (PAO) and/or derotational femoral osteotomy with a minimum of 2-year follow-up, were included in the analysis. Patients undergoing surgical treatment for diagnoses of slipped capital femoral epiphysis, Legg-Calves-Perthe disease, osteochondromatosis, or postdislocation syndrome, as well as patients who refused to participate in the study, were excluded. We compared the patient-reported outcomes (PROs) for patients who underwent arthroscopic bone grafting with a case-matched control group without acetabular cysts with the same surgical route (hip arthroscopy or hip arthroscopy followed by PAO). An “inside-out” arthroscopic bone grafting technique was utilized, which allowed for precise access to the cystic cavity through the articular side. We analyzed postoperative PROs at a minimum of 2 years postoperatively using the international Hip Outcome Tool (iHOT-12) and Nonarthritic Hip Score (NAHS). Results: In total, there were 44 hips in the experimental group and 78 hips in the control group. The mean PRO interval in the experimental group was 3.4 years (range, 2-5 years postoperatively), with 20 patients reaching PROs 5 years postoperatively. The experimental group reported significant improvement of iHOT-12 and NAHS scores postoperatively (both P < .001). Postoperative iHOT-12 and NAHS scores did not significantly differ between groups over a 5-year follow-up interval ( P = .26 and .17, respectively). Radiographic evidence of cyst healing was achieved in all 7 patients who underwent postoperative magnetic resonance imaging, with 3 cases of complete resolution. Conclusion: Acetabular subchondral cysts treated with an inside-out method of arthroscopic bone grafting in the setting of hip preservation surgery with or without PAO was associated with a significant improvement in midterm PROs, comparable with a control group of patients without acetabular cysts who did not undergo bone grafting. Our results support the use of arthroscopic grafting in appropriately selected patients and suggest that hip preservation is not contraindicated in patients with acetabular subchondral cysts.
MRI delta radiomics during chemoradiotherapy for prognostication in locally advanced cervical cancer
Authors: Wagner-Larsen Kari S. , Lura Njål , Gulati Ankush , Ryste Stian , Hodneland Erlend , Fasmer Kristine E. , Woie Kathrine , Bertelsen Bjørn I. , Salvesen Øyvind , Halle Mari K. , Smit Noeska , Krakstad Camilla , Haldorsen Ingfrid S. 
Published: January 2025

Abstract

Background
Effective diagnostic tools for prompt identification of high-risk locally advanced cervical cancer (LACC) patients are needed to facilitate early, individualized treatment. The aim of this work was to assess temporal changes in tumor radiomics (delta radiomics) from T2-weighted imaging (T2WI) during concurrent chemoradiotherapy (CCRT) in LACC patients, and their association with progression-free survival (PFS). Furthermore, to develop, validate, and compare delta- and pretreatment radiomic signatures for prognostic modeling.

Methods
A total of 110 LACC patients undergoing CCRT with MRI at baseline and mid-treatment were divided into training (cohortT: n = 73) and validation (cohortV: n = 37) cohorts. Radiomic features were extracted from tumors segmented on pre-CCRT and mid-CCRT T2WI and radiomic deltas (delta features) were computed. Two radiomic signatures for predicting PFS were constructed by least absolute shrinkage and selection operator (LASSO) Cox regression: Deltarad (from delta features) and Pre-CCRTrad (from pre-CCRT features). Prognostic performance of the radiomic signatures, 2018 International Federation of Gynecology and Obstetrics (FIGO) stage (I–IV), and baseline MRI-derived maximum tumor diameter (Tumormax: ≤2 cm; >2 and ≤ 4 cm; >4 cm) was evaluated by area under time-dependent receiver operating characteristics (tdROC) curves (AUC) in cohortT and cohortV (AUCT/AUCV). Mann–Whitney U tests assessed differences in radiomic delta features. PFS was evaluated using the Kaplan–Meier method with log-rank tests.

Results
Deltarad (AUCT/AUCV: 0.74/0.79) marginally outperformed Pre-CCRTrad (0.72/0.75) for predicting 5-year PFS, and both signatures clearly surpassed that of FIGO (0.61/0.61) and Tumormax (0.58/0.65). In total, four features within Deltarad and Pre-CCRTrad significantly differed in delta feature values between progressors and non-progressors, being consistently lower in progressors (p ≤ 0.03 for all). High Deltarad and Pre-CCRTrad radiomic scores were associated with poor PFS (p ≤ 0.04 for Deltarad in cohortT/Pre-CCRTrad in both cohorts; p = 0.11 for Deltarad in cohortV).

Conclusions
Delta- and pretreatment radiomic signatures equally allow early prognostication in LACC, outperforming FIGO stage and MRI-assessed maximum tumor diameter.
Lidocaine could promote the cuproptosis through up-regulating the long noncoding RNA DNMBP-AS1 in Hep-2 cells
Authors: Liu Wei , Yu Yi , He Yi , Lv Meihong 
Published: January 2025

Abstract

Background
Lidocaine is a traditional local anesthetic, which has been reported to trigger apoptosis through the mitochondrial pathway, independent of death receptor signaling. Cuproptosis is a copper triggered mitochondrial cell death mode. In this study, we explored the biological effects of lidocaine on cuproptosis in Hep-2 cells and studied the relevant mechanisms.

Methods
quantitative RT-PCR was used to measure the expression level of long noncoding RNA (IncRNA) DNMBP-AS1. DNMBP-AS1 siRNA (si-DNMBP-AS1) were transfected into Hep-2 cells to verify the roles of DNMBP-AS1 in cuproptosis. 24 h treatment with 20 nM elesclomol and 2 µM CuCl2 was performed to promote the occurrence of Cuproptosis. Cell proliferation, migration and apoptosis assays ware utilized to analyze biological effect of lidocaine and DNMBP-AS1 on Hep-2 cells. Active caspase-3 were also determined after treatment.

Results
DNMBP-AS1 was significantly upregulated during cuproptosis in Hep-2 cells. The si-DNMBP-AS1 significantly increased the cell viability with nonactivated caspase-3, promoted the cell migration and suppress the cuproptosis. Lidocaine was cytotoxic to the Hep-2 cells in a dose- and time-dependent manner. Exposure to 10 µM of lidocaine for 24 h did not reduce the viability or activated the caspase-3, but significantly increased the expression of DNMBP-AS1, and promote the cuproptosis. Anymore, si-DNMBP-AS1 reversed the pro-cuproptosis function of lidocaine.

Conclusions
lidocaine was cytotoxic to Hep-2 cells in a time- and dose-dependent manner, promoted the cuproptosis through up-regulating DNMBP-AS1. The results of this study offered initial optimism that lidocaine could be used in an adjuvant or neoadjuvant fashion in cancer treatment.
Exploring how course social and cultural environmental features influence student engagement in STEM active learning courses: a control–value theory approach
Authors: Choi Yoon Ha , Theobald Elli , Velasco Vicente , Eddy Sarah L. 
Published: January 2025

Abstract

Background
Active learning, on average, increases student performance in STEM courses. Yet, there is also large variation in the effectiveness of these implementations. A consistent goal of active learning is moving students towards becoming active constructors of their knowledge. This emphasis means student engagement is of central importance. Thus, variation in student engagement could help explain variation in outcomes from active learning. In this study, we employ Pekrun’s Control–Value Theory to examine the impact of four aspects of course social and cultural environments on student engagement. This theory posits that social and cultural features of the course environment influence students’ appraisals of their ability to control their academic outcomes from the course and the value they see in those outcomes. Control and value in turn influence the emotions students experience in the course and their behaviors. We selected four features of the course environment suggested in the literature to be important in active learning courses: course goal structure, relevance of course content, students’ trust in their instructor, and perceived course competition.

Results
We surveyed students in 13 introductory STEM courses. We used structural equation modeling to map how features of the course environment related to control, value, and academic emotions, as well as how control, value, and academic emotions influenced engagement. We found engagement was positively related to control and value as well as the emotion of curiosity. Engagement was negatively related to the emotion of boredom. Importantly, features of the course environment influenced these four variables. All features influenced control: goal structure, relevance, and instructor trust increased it, while competition decreased it. All features except competition were related positively to value. Relevance and instructor trust increased curiosity. Goal structure, relevance, and instructor trust all reduced boredom, while competition increased it.

Conclusion
Overall, our study suggests that the way instructors structure the social and cultural environment in active learning courses can impact engagement. Building positive instructor–student relationships, reducing course competition, emphasizing mastery and the relevance of the course to students can all increase engagement in course activities.
Changes in nutritional management after gastrointestinal cancer surgery over a 12-year period: a cohort study using a nationwide medical claims database
Authors: Kawaguchi Yoshikuni , Murotani Kenta , Hayashi Nahoki , Kamoshita Satoru 
Published: January 2025

Abstract

Background
Nutritional management in patients after gastrointestinal cancer surgery has changed throughout the 2000s. However, its evolution has not been formally studied. This study aimed to evaluate changes in nutritional management using real-world data.

Methods
Patient data from 2011 to 2022 were extracted from a nationwide medical claims database. Patients were divided into four groups based on their year of hospital admission: period I, 2011–2013; II, 2014–2016; III, 2017–2019; IV, 2020–2022. For each period, feeding routes in all patients and prescribed doses of parenteral energy and amino acids in fasting patients during postoperative days (POD) 1–7 were determined. The results of the four different periods were compared using statistical trend tests.

Results
The study cohort was comprised of 365,125 patients. During POD 1–3, the proportion of patients administered any oral intake increased over time (I, 40.3%; II, 47.1%; III, 49.4%; IV, 54.2%; P < 0.001), while that of patients receiving parenteral nutrition (PN) decreased (I, 60.1%; II, 55.0%; III, 50.3%; IV, 45.5%; P < 0.001). Of 19,661 patients with PN alone (i.e., neither oral intake nor enteral nutrition) during POD 1–7, the median (interquartile range) prescribed doses on POD 7 of energy (kcal/kg) [I, 15.3 (10.3–21.9); II, 13.9 (8.4–20.0); III, 13.2 (7.7–19.2); IV, 12.9 (7.0–18.7); P < 0.001] and amino acids (g/kg) [I, 0.65 (0.30–0.94); II, 0.58 (0.24–0.89); III, 0.56 (0.00–0.86); IV, 0.56 (0.00–0.87); P < 0.001] both decreased over time.

Conclusion
From 2011 to 2022, more patients who underwent gastrointestinal cancer surgery in Japan were administered early oral intake, while fewer patients were administered early PN. Overall, the energy and amino acid doses prescribed in PN were far below the guideline recommendations.
Deciphering the potential ability of DExD/H-box helicase 60 (DDX60) on the proliferation, diagnostic and prognostic biomarker in pancreatic cancer: a research based on silico, RNA-seq and molecular biology experiment
Authors: Zhang Dongdong , Zhang Enze , Cai Ying , sun Yixin , Zeng Peiji , Jiang Xiaohua , Lian Yifan 
Published: January 2025

Abstract

Background
Pancreatic cancer is one of the most malignant abdominal tumors. DDX60 has been shown to be associated with a variety of tumor biological processes. However, DDX60 in pancreatic cancer has not been reported. Our study confirmed that DDX60 can serve as a novel biomarker for diagnosis and treatment of pancreatic cancer.

Materials and methods
We downloaded pancreatic cancer datasets from GEO and TCGA databases, respectively. To investigate the relationship between DDX60 expression and prognosis in pancreatic cancer. GSEA analysis was performed on DDX60. We performed RNA-seq to further explore the downstream biological targets of DDX60 and the signaling pathways that may be involved in pancreatic cancer. Finally, we tested it through molecular biology experiments. First, we constructed the plasmid and tested the plasmid effect by WB. Then MTT assay was performed to explore the effect of DDX60 knockout on the proliferation of pancreatic cancer cells. LDH assay was performed to explore the effect of DDX60 on the release of lactate dehydrogenase from tumor cells. The effect of DDX60 on cell proliferation was further explored by clonal formation experiment. Continue to explore clinical therapeutic drugs sensitive to DDX60 targets.

Results
By analyzing the GSE71729, GSE183795, GSE16515, GSE28735 and GSE62452 data sets, we found that DDX60 was highly expressed in pancreatic cancer. And is associated with poorer outcomes for pancreatic patients. The mRNA expression level of DDX60 was correlated with lymph node metastasis and grade in clinical pancreatic patients. Through the results of RNA-seq analysis, GO and KEGG analysis showed that DDX60 may be associated with cell cycle in pancreatic cancer. Through molecular biology experiments (MTT, LDH, and clonal formation experiment), we found that When DDX60 is knocked down in pancreatic cancer cells, the proliferation ability of tumor cells is significantly decreased. Several drugs targeting about DDX60 have been found, such as JW-7–52-1, this could provide direction for drug therapy against the DDX60 target.

Conclusion
In summary, DDX60 can be used as a novel biomarker related to the diagnosis and treatment of pancreatic cancer, participate in tumor proliferation, and is associated with poor prognosis in patients.
Novel pain management strategy for uterine fibroid embolization
Authors: Ho Elaine , Tan Kiat Tsong 
Published: January 2025

Abstract

Background
Uterine fibroid embolization can be associated with significant pain due to fibroid ischemia and interventions of the procedure itself. Fentanyl and midazolam are commonly provided for sedation and pain relief, but are not tolerated by all patients. This report outlines a novel pain management strategy for uterine fibroid embolization in a patient who could not receive either opioids or benzodiazepines.

Methods
A 51 year old woman presenting with menorrhagia due to uterine fibroids was referred to interventional radiology for embolization. She was allergic to most opiates and had previously become agitated with IV midazolam, resulting in termination of a previous attempt at embolization. Thus, a combination of three analgesic modalities was used: intraarterial ropivacaine in the uterine arteries, superior hypogastric nerve block with ropivacaine, and intravenous acetaminophen. The patient underwent successful embolization and reported only intermittent pain of 1–2 out of 10 intensity.

Discussion
This combined analgesic cocktail represents a novel alternative to traditional sedation for uterine fibroid embolization and may serve as a viable option for patients with similar contraindications.
Privacy-preserving attribute-based access control using homomorphic encryption
Authors: Kerl Malte , Bodin Ulf , Schelén Olov 
Published: January 2025

Abstract
Authentication and access control for Cyber-Physical Systems (CPSs) are pivotal for protecting systems and their users from problems related to harmful actions and the malicious use of retrieved data. In some situations, making access decisions requires using user information, thereby challenging their privacy. Attribute-based access control (ABAC) supports dynamic and context-aware access decisions that are attractive in cyber-physical system environments. However, privacy preservation for access decisions is an open issue for authorization and is not supported by existing ABAC models. For example, if access decisions need to be made based on private attribute values such as health data, the corresponding access control policies need to be revealed. This paper reviews the ABAC, homomorphic encryption (HE), and zero-knowledge proof (ZKP) approaches, confirming the gap in privacy preservation in ABAC. Based on this observation, we further present the application of a new ZKP-based protocol in which ABAC allows for the privacy-preserving evaluation of attributes. This protocol is implemented and evaluated in terms of its performance and security. The evaluation demonstrates that there is a possibility for privacy-preserving ABAC, which may benefit the use of CPS, e.g., in underground and open-pit mines.
The simultaneous interaction of MSL2 with CLAMP and DNA provides redundancy in the initiation of dosage compensation in Drosophila males
Authors: Tikhonova Evgeniya , Fedotova Anna , Bonchuk Artem , Mogila Vladic , Larschan Erica N. , Georgiev Pavel , Maksimenko Oksana 
Published: January 2025

ABSTRACT
The binding of the Drosophila male-specific lethal dosage compensation complex (DCC) exclusively to the male X chromosome provides an excellent model system to understand mechanisms of selective recruitment of protein complexes to chromatin. Previous studies showed that the male-specific organizer of the complex, MSL2, and the ubiquitous DNA-binding protein CLAMP are key players in the specificity of X chromosome binding. The CXC domain of MSL2 binds to genomic sites of DCC recruitment in vitro. Another conserved domain of MSL2, named Clamp-binding domain (CBD) directly interacts with the N-terminal zinc-finger domain of CLAMP. Here, we found that inactivation of CBD or CXC individually only modestly affected recruitment of the DCC to the X chromosome in males. However, combination of these two genetic lesions within the same MSL2 mutant resulted in an increased loss of DCC recruitment to the X chromosome. Thus, proper MSL2 positioning requires an interaction with either CLAMP or DNA to initiate dosage compensation in Drosophila males.