bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rhino-orbito-cerebral invasive fungal sinusitis associated with COVID-19 infection in a malnurished child
Authors: Kariyappa Mallesh , Patel Ashray Sudarshan , Dhanalakshmi K , Dakshayani B 
Published: January 2023

Abstract
Background
Corona virus disease has been associated with a wide variety of fungal and bacterial co-infections. These secondary infections could be due to the irrational use of antibiotics, immunosuppressive therapy, pre-existing co morbidities, and immune modulator effects of the virus. But here, we report a very rare occurring of rhino-orbito-cerebral invasive fungal sinusitis in a malnourished child and no other co morbidities.

Case presentation
This is a case of a 6-year-old boy with severe thinness and no other co-morbidities, with mild COVID-19 infection, during the course of illness developed rhino-orbito-cerebral invasive fungal sinusitis. The child’s mother had COVID-19 1 week prior to child’s illness. The child then developed fever followed by headache. The child reported to hospital on seventh day of illness and RTPCR for COVID-19, turned positive. The child’s vitals were stable and maintaining saturation. Child was being treated with supplements and symptomatic treatment for fever. On his second day of stay at hospital, he started to develop gradually progressive left-sided peri-orbital swelling. Due to the association of COVID-19 with fungal infection, child was started on AMPHOTERICIN-B and given for 4 days and referred to a higher center for further management. Radiological imaging was suggestive of rhino-sinusitis with orbital cellulitis with meningeal enhancement suggestive of fungal etiology. Debridement was done, child was adequately treated with anti-fungal, and the child showed significant improvement along with radiological clearing.

Conclusion
Invasive fungal infection can occur in association with COVID-19 among malnourished pediatric age groups with no other comorbidities.
Meta-analysis on PET plastic as concrete aggregate using response surface methodology and regression analysis
Authors: Chong Beng Wei , Shi Xijun 
Published: January 2023

AbstractThis paper aims to thoroughly analyze the effect of polyethylene terephthalate (PET) plastic aggregate on concrete compressive strength using a meta-analysis. Forty-three datasets for concrete containing PET coarse aggregate and 60 data sets for concrete containing PET fine aggregate were collected. The input variables used were percentage and nominal maximum size of PET aggregate along with the concrete mix proportions. Main effect plots, contour plots, and surface plots of the expressions were presented to demostrate the effect of PET aggregate on the 28-day compressive strength of concrete. The statistical parameters of the regression equations, such as R2, adjusted R2 and root-mean-square error (RMSE), indicated that the RSM approach is a powerful tool to describe the change of concrete compressive strength by PET aggregate addition. In addition, the study showed that using PET plastic as a fine aggregate replacement performed better than using it as a coarse aggregate replacement in concrete. At up to 30% replacement, concrete containing PET plastic as a fine aggregate can have satisfactory compressive strength.
Light control with Weyl semimetals
Authors: Guo Cheng , Asadchy Viktar S. , Zhao Bo , Fan Shanhui 
Published: January 2023

AbstractWeyl semimetals are topological materials whose electron quasiparticles obey the Weyl equation. They possess many unusual properties that may lead to new applications. This is a tutorial review of the optical properties and applications of Weyl semimetals. We review the basic concepts and optical responses of Weyl semimetals, and survey their applications in optics and thermal photonics. We hope this pedagogical text will motivate further research on this emerging topic.
Development and Validation of a Genomic Profile for the Omission of Local Adjuvant Radiation in Breast Cancer
Authors: Sjöström Martin , Fyles Anthony , Liu Fei-Fei , McCready David , Shi Wei , Rey-McIntyre Katrina , Chang S. Laura , Feng Felix Y. , Speers Corey W. , Pierce Lori J. , Holmberg Erik , Fernö Mårten , Malmström Per , Karlsson Per 
Published: January 2023

PURPOSE Adjuvant radiotherapy (RT) is used for women with early-stage invasive breast cancer treated with breast-conserving surgery. However, some women with low risk of recurrence may safely be spared RT. This study aimed to identify these women using a molecular-based approach. METHODS We analyzed two randomized trials of women with node-negative invasive breast cancer to ± RT following breast-conserving surgery: SweBCG91-RT (stage I-II, no adjuvant systemic therapy) and Princess Margaret (age 50 years or older, T1-T2, adjuvant tamoxifen). Transcriptome-wide profiling was performed (Affymetrix Human Exon 1.0 ST microarray). Patients with estrogen receptor–positive/human epidermal growth factor receptor 2–negative tumors and with gene expression data were included. The SweBCG91-RT cohort was divided into training (N = 243) and validation (N = 354) cohorts. A 16-gene signature named Profile for the Omission of Local Adjuvant Radiation (POLAR) was trained to predict locoregional recurrence (LRR) using elastic net regression. POLAR was then validated in the SweBCG91-RT validation cohort and the Princess Margaret cohort (N = 132). RESULTS Patients categorized as POLAR low-risk without RT had a 10-year LRR of 6% (95% CI, 2 to 16) and 7% (0 to 27) in SweBCG91-RT and Princess Margaret cohorts, respectively. There was no significant benefit from RT in POLAR low-risk patients (hazard ratio [HR], 1.1 [0.39 to 3.4], P = .81, and HR, 1.5 [0.14 to 16], P = .74, respectively). Patients categorized as POLAR high-risk had a significant decreased risk of LRR with RT (HR, 0.43 [0.24 to 0.78], P = .0055, and HR, 0.25 [0.07 to 0.92], P = .038, respectively). An exploratory analysis testing for interaction between RT and POLAR in the combined validation cohort was performed ( P = .066). CONCLUSION The novel POLAR genomic signature on the basis of LRR biology may identify patients with a low risk of LRR despite not receiving RT, and thus may be candidates for RT omission.
Cost-Effectiveness Analysis of Six Immunotherapy-Based Regimens and Sunitinib in Metastatic Renal Cell Carcinoma: A Public Payer Perspective
Authors: Yoo Minkyoung , Nelson Richard E. , Cutshall Zachary , Dougherty Maura , Kohli Manish 
Published: January 2023

PURPOSE: Several new treatment combinations have been approved in metastatic renal cell carcinoma (mRCC). To determine the optimal therapy on the basis of cost and health outcomes, we performed a cost-effectiveness analysis of approved immunotherapy-tyrosine kinase inhibitor/immunotherapy drug combinations and sunitinib using public payer acquisition costs in the United States. METHODS: We constructed a decision model with a 10-year time horizon. The seven treatment drug strategies included atezolizumab + bevacizumab, avelumab + axitinib, pembrolizumab + axitinib, nivolumab + ipilimumab (NI), nivolumab + cabozantinib, lenvatinib + pembrolizumab, and sunitinib. The effectiveness outcome in our model was quality-adjusted life-years (QALYs) with utility values on the basis of the published literature. Costs included drug acquisition costs and costs for management of grade 3-4 drug-related adverse events. We used a partitioned survival model in which patients with mRCC transitioned between three health states (progression-free, progressive disease, and death) at monthly intervals on the basis of parametric survival function estimated from published survival curves. To determine cost-effectiveness, we constructed incremental cost-effectiveness ratios (ICERs) by dividing the difference in cost by the difference in effectiveness between nondominated treatments. RESULTS: The least expensive treatment was sunitinib ($357,948 US dollars [USD]-$656,100 USD), whereas the most expensive was either lenvatinib + pembrolizumab or pembrolizumab + axitinib ($959,302 USD-$1,403,671 USD). NI yielded the most QALYs (3.6), whereas avelumab + axitinib yielded the least (2.5). NI had an incremental ICER of $297,465 USD-$348,516 USD compared with sunitinib. In sensitivity analyses, this ICER fell below $150,000 USD/QALY if the initial 4-month cost of NI decreased by 22%-38%. CONCLUSION: NI was the most effective combination for mRCC, but at a willingness-to-pay threshold of $150,000 USD/QALY, sunitinib was the most cost-effective approach.
The Health Benefits of Resistance Exercise: Beyond Hypertrophy and Big Weights
Authors: Abou Sawan Sidney , Nunes Everson A. , Lim Changhyun , McKendry James , Phillips Stuart M. 
Published: January 2023

ABSTRACT
It is well established that exercise is associated with a reduced risk of several chronic diseases. Currently, aerobic training (AT) receives primary attention in physical activity guidelines with a recommendation for ~150 min of moderate-to-vigorous AT weekly. In most physical activity guidelines, resistance training (RT) is termed a beneficial activity, with a recommendation to engage in strengthening activities twice weekly. However, we propose that the health benefits of RT are underappreciated. There is evidence, established and emerging, that RT can, in many respects, elicit similar health benefits to AT. When combined, AT and RT may yield ostensibly optimal health benefits versus performing either exercise exclusively. We discuss the health benefits of engaging in RT, including healthy aging, improved mobility, cognitive function, cancer survivorship, and metabolic health in persons with obesity and type 2 diabetes—all of which can influence morbidity and mortality. Many of the health benefits of RT can be achieved by lifting lighter loads to volitional failure, highlighting that the benefits of RT do not necessarily require lifting heavier weights. Accumulating evidence also shows a lower mortality risk in those who regularly perform RT. To optimize health, especially with aging, RT should be emphasized in physical activity guidelines in addition to AT.
Low Bone Mineral Density and Associated Risk Factors in Elite Cyclists at Different Stages of a Professional Cycling Career
Authors: HILKENS LUUK , VAN SCHIJNDEL NICK , WEIJER VERA , BOERBOOM MARLEEN , VAN DER BURG ESTHER , PETERS VELIBOR , KEMPERS ROBERT , BONS JUDITH , VAN LOON LUC J. C. , VAN DIJK JAN-WILLEM 
Published: January 2023

ABSTRACT

Purpose
This study aimed to assess the prevalence of low bone mineral density (BMD) in male and female elite cyclists at different stages of a professional cycling career and to identify potential risk factors of low BMD.

Methods
In this cross-sectional study, 93 male and female early career, advanced career, and postcareer elite cyclists completed dual-energy x-ray absorptiometry at the hip, femoral neck, lumbar spine, and total body; blood sampling; assessment of training history and injuries; and the bone-specific physical activity questionnaire. Backward stepwise multiple regression analyses were conducted to explore associations between BMD and its potential predictors in early and advanced career (i.e., active career) cyclists.

Results
With a mean Z-score of −0.3 ± 0.8, −1.5 ± 1.0, and −1.0 ± 0.9, low BMD (Z-score < −1) at the lumbar spine was present in 27%, 64%, and 50% of the early, advanced, and postcareer elite male cyclists, respectively. Lumbar spine Z-scores of −0.9 ± 1.0, −1.0 ± 1.0, and 0.2 ± 1.4 in early, advanced, and postcareer elite female cyclists, respectively, indicated low BMD in 45%, 45%, and 20% of these female subpopulations. Regression analyses identified body mass index, fracture incidence, bone-specific physical activity, and triiodothyronine as the main factors associated with BMD.

Conclusions
Low BMD is highly prevalent in elite cyclists, especially in early career females and advanced career males and females. These low BMD values may not fully recover after the professional cycling career, given the substantial prevalence of low BMD in retired elite cyclists. Exploratory analyses indicated that low BMD is associated with low body mass index, fracture incidence, lack of bone-specific physical activity, and low energy availability in active career elite cyclists.
A model of coercive control in higher education: a qualitative study
Authors: Jakovljevic Maria , Nkopodi Nkopodi 
Published: January 2023

Background: A growing body of research indicates that psychological coercive control poses a threat in academic environments. Little is known, however, about the process, the dynamics, and the phases used to impose silently a variety of non-violent assaults on students and academics. A lack of awareness of coercive intimidation and psychological coercive control obstructs a student’s path to academic achievement, which can have an impact on his or her emotional and mental well-being and diminishes the prosperity of society. Methods: A methodological selection and review of the scientific literature, theories, and practice on psychological intimidation, coercive control, and systems thinking has been employed in this study. A comprehensive reflective analysis and critical synthesis of the relevant scientific literature were conducted to gain insight into the design of a model of psychological coercive control applicable to educational environments. Results: This article identifies gaps in research theory and practice and examines critical issues of intimidation and psychological coercive control that is relevant to educational contexts. The article proposes a conceptual model of psychological coercive control as a direction for further research. Conclusions: Adequate awareness, models, and training programmes in relation to coercive infiltration are missing at higher education institutions. There is an urgent need for a curriculum change that may serve to promote support systems thinking and security awareness in educational environments.
GLP-1 agonists in treatment of obesity
Authors: Orłowski Władysław , Merkisz Konrad , Zdun Sylwia , Walczak Klaudia , Walczak Patrycja , Nemeczek Sylwia , Grzybowski Jakub , Marciniak Agnieszka , Jaskuła Karolina , Grzywna Natalia 
Published: January 2023

Background: Obesity is a major problem nowadays. It has correlation with metabolic and cardiovascular diseases. Due to that it is very important to diagnose and treat obesity properly.
Objective: The purpose of our work is to show effectiveness of GLP1 agonist in treating obesity.
Method: A literature review was conducted in PubMed database using the key words: „Semaglutide obesity” „Tirzepatide obesity” „Liraglutide obesity” „obesity”.
Results: Using particular drug in addition to lifestyle modification appears to be more effective than using placebo with lifestyle modification.
Conclusions: Trials showed effectiveness of GLP1 analogs in treatment of obesity. These drugs might be a future of managing with obesity, but we do not know yet how long lasting is the effect of these drugs. The upcoming years will bring us more trials, but in this moment we can say that they have a lot of potential.
Eight-port Diagonal Antenna with High Isolation and High Efficiency for 5G Smartphone
Authors: Shao Rui , Wang Junlin , Wang Xin , Wang Yonghao 
Published: January 2023

In this letter, an 8x8 multiple-input-multiple-output (MIMO) antenna that operates in the sub-6 GHz (4.7-5.1 GHz) spectrum for 5G MIMO smartphone applications is presented. The design consists of a fully grounded plane with closely orthogonal antenna pairs placed symmetrically on the corners of the smartphone and each antenna element consists of an F-type monopole with dimensions of 18x7.5mm2. Firstly, the diversity characteristics of orthogonally placed antennas are used to reduce the coupling between antennas. On the other hand, diagonal antennas are connected by a neutral line (NL) to further improve isolation and etched slots on the ground to reduce the coupling between antenna pairs. A good frequency bandwidth (S11 < -10 dB) of 4.7-5.1 GHz has been obtained for the MIMO antenna, and the isolation is lower than 16 dB. In addition, total efficiency (TE) is greater than 77.5%, and the envelope correlation coefficient (ECC) is lower than 0.025. The fabricated antenna prototype is tested and offers good performance.
Use of research evidence in legislatures: a systematic review
Authors: Ouimet Mathieu , Beaumier Morgane , Cloutier Adrien , Côté Alexandre , Montigny Éric , Gélineau François , Jacob Steve , Ratté Stéphane 
Published: January 2023

Background:
Although lawmakers play an essential role in policymaking, there is no systematic review on the use of research evidence in legislatures.
Aims and objectives:
To examine types of research use and factors facilitating and hindering use in legislatures.
Methods:
We conducted a systematic review of studies in legislatures, regardless of geographical region or year of publication. We included empirical studies irrespective of the methodology employed. Thematic synthesis was used to synthesise the type of use and the facilitating and hindering factors to using research evidence in parliaments. We included 21 studies.
Findings:
The most frequently observed type of utilisation was the use for symbolic or tactical purposes. Forms of use specific to legislatures were also identified, such as to prepare questions and debates and to help build consensus. Four categories of factors seen as facilitators or barriers were found: institution and organisation, research characteristics, policy and political context, and individual characteristics. Some factors had already been identified in previous reviews, while others seem to apply exclusively to legislatures.
Discussion and conclusions:
The review identified types of use of research evidence observed in legislatures and developed a new categorisation of factors that may promote or hinder evidence use in this institutional setting. It highlighted a need for more research beyond the US, in unicameral legislatures and in countries with a parliamentary form of government. Content analysis of parliamentary debates in legislative assembly or committee to examine the use of research evidence seems to be underused.
Understanding headache classification coding within the veterans health administration using ICD-9-CM and ICD-10-CM in fiscal years 2014–2017
Authors: Fodeh Samah Jamal , Fenton Brenda T. , Wang Rixin , Skanderson Melissa , Altalib Hamada , Kuruvilla Deena , Schindler Emmanuelle , Haskell Sally , Brandt Cynthia , Sico Jason J. 
Published: January 2023

Objectives
Understand the continuity and changes in headache not-otherwise-specified (NOS), migraine, and post-traumatic headache (PTH) diagnoses after the transition from ICD-9-CM to ICD-10-CM in the Veterans Health Administration (VHA).

Background
Headache is one of the most commonly diagnosed chronic conditions managed within primary and specialty care clinics. The VHA transitioned from ICD-9-CM to ICD-10-CM on October-1-2015. The effect transitioning on coding of specific headache diagnoses is unknown. Accuracy of headache diagnosis is important since different headache types respond to different treatments.

Methods
We mapped headache diagnoses from ICD-9-CM (FY 2014/2015) onto ICD-10-CM (FY 2016/2017) and computed coding proportions two years before/after the transition in VHA. We used queries to determine the change in transition pathways. We report the odds of ICD-10-CM coding associated with ICD-9-CM controlling for provider type, and patient age, sex, and race/ethnicity.

Results
Only 37%, 58% and 34% of patients with ICD-9-CM coding of NOS, migraine, and PTH respectively had an ICD-10-CM headache diagnosis. Of those with an ICD-10-CM diagnosis, 73–79% had a single headache diagnosis. The odds ratios for receiving the same code in both ICD-9-CM and ICD-10-CM after adjustment for ICD-9-CM and ICD-10-CM headache comorbidities and sociodemographic factors were high (range 6–26) and statistically significant. Specifically, 75% of patients with headache NOS had received one headache diagnoses (Adjusted headache NOS-ICD-9-CM OR for headache NOS-ICD-10-CM = 6.1, 95% CI 5.89–6.32. 79% of migraineurs had one headache diagnoses, mostly migraine (Adjusted migraine-ICD-9-CM OR for migraine-ICD-10-CM = 26.43, 95% CI 25.51–27.38). The same held true for PTH (Adjusted PTH-ICD-9-CM OR for PTH-ICD-10-CM = 22.92, 95% CI: 18.97–27.68). These strong associations remained after adjustment for specialist care in ICD-10-CM follow-up period.

Discussion
The majority of people with ICD-9-CM headache diagnoses did not have an ICD-10-CM headache diagnosis. However, a given diagnosis in ICD-9-CM by a primary care provider (PCP) was significantly predictive of its assignment in ICD-10-CM as was seeing either a neurologist or physiatrist (compared to a generalist) for an ICD-10-CM headache diagnosis.

Conclusion
When a veteran had a specific diagnosis in ICD-9-CM, the odds of being coded with the same diagnosis in ICD-10-CM were significantly higher. Specialist visit during the ICD-10-CM period was independently associated with all three ICD-10-CM headaches.
Spatial inequality and explaining the urban-rural gap in obesity in India: Evidence from 2015–16 population-based survey
Authors: Barua Somdutta 
Published: January 2023

Objective
This study assessed the spatial dimension of urban-rural disparity in obesity prevalence and identified the determinants explaining the urban-rural gap in obesity prevalence in India.

Methods
Using cross-sectional survey data from the 2015–16 National Family Health Survey, the prevalence rates of obesity were calculated for aged 15–49 years. Two multiscale geographically weighted regressions were performed separately from rural and urban spaces for Indian districts to examine the spatial relationship of the outcome variable and covariates at different geographical scales. Fairlie decomposition analysis was carried out to explore the contribution of each variable in the urban-rural gap.

Results
The rural-urban obesity prevalence difference has increased in a decade time for India from 13.0 to 14.6. Urban counterparts tended to have more people with excess weight. 15 states had an urban-rural prevalence ratio of 2 or higher. The MGWR model showed that varying covariates operated at different scales, i.e. global, regional and local scales, and determined the spatial heterogeneity of obesity prevalence. The only variable, i.e. age (9.49 per cent), had contributed in reducing the gap. Conversely, the socioeconomic variables, i.e. income (96.39 per cent), education (4.95 per cent), caste (4.78 per cent) and occupation (3.11 per cent), had widened the gap.

Conclusions
Even though this study evidenced the rural-urban gap in obesity prevalence, it indicated the gap’s closing shortly, as it was witnessed in a few states. It is urgent to address the obesity epidemic, especially in urban India, due to its higher prevalence and prevent the further increase of prevalence in rural India, mainly because it shelters nearly 70 per cent of the Indian population.