bluuebunny/crossref_metadata_2025_split huggingface dataset:
Drivers of Marine CO2‐Carbonate Chemistry in the Northern Antarctic Peninsula
Authors: Santos‐Andrade Maurício , Kerr Rodrigo , Orselli Iole B. M. , Monteiro Thiago , Mata Mauricio M. , Goyet Catherine 
Published: February 2023

AbstractThe Bransfield Strait is a climate change hotspot at the tip of the northern Antarctic Peninsula (NAP). The region is marked by a mixture of relatively warm waters from the Bellingshausen Sea with cold shelf waters from the Weddell Sea. Additionally, its deep central basin (>800 m) preserves seawater properties from the north‐western Weddell Sea continental shelf. This study assessed long‐term changes in carbonate chemistry in the Bransfield Strait and found that the hydrographic setting (i.e., a mixture between modified‐Circumpolar Deep Water with Dense Shelf Water [DSW]) drives temporal variability of carbonate parameters. The western basin has experienced decreases in pH (seawater scale) over the last three decades (1996–2019), varying from −0.003 to −0.017 pH units yr−1, while Ωar decreased from −0.01 to −0.07 yr−1 throughout the water column. The central basin was characterized by a high contribution of DSW with high carbon dioxide (CO2) content and the decomposition of organic matter produced and transported into its deep layer. With lower variability for all carbonate system variables, the eastern basin was likely regulated by internal mixing. Overall, the entire strait is almost reaching a CO2‐saturated condition, highlighting how sensitive subpolar regions are to the effects of human‐induced climate change.
Accelerated epigenetic aging in women with emotionally unstable personality disorder and a history of suicide attempts
Authors: Boström Adrian Desai E. , Andersson Peter , Jamshidi Esmail , Wilczek Alexander , Nilsonne Åsa , Rask-Andersen Mathias , Åsberg Marie , Jokinen Jussi 
Published: February 2023

AbstractEmotional unstable personality disorder (EUPD; previously borderline personality disorder, BPD) is associated with excess natural-cause mortality, comorbid medical conditions, poor health habits and stress related epigenomic alterations. Previous studies demonstrated that GrimAge – a state-of-the-art epigenetic age (EA) estimator – strongly predicts mortality risk and physiological dysregulation. Herein, we utilize the GrimAge algorithm to investigate whether women with EUPD and a history of recent suicide attempts exhibit EA acceleration (EAA) in comparison to healthy controls. Genome-wide methylation patterns were measured using the Illumina Infinum Methylation Epic BeadChip in whole blood from 97 EUPD patients and 32 healthy controls. The control group was significantly older (p < 0.0001) and reported lesser exposure to violent behavior in both youth and adulthood (p < 0.0001). Groups were otherwise comparable regarding gender, BMI, or tobacco usage (p > 0.05). EA estimator DNAmGrimAge exceeded chronological age by 8.8 and 2.3 years in the EUPD and control group, respectively. Similarly, EAA marker AgeAccelGrim was substantially higher in EUPD subjects when compared to controls, in both univariate and multivariate analyzes (p < 0.00001). Tobacco usage conferred substantial within-group effects on the EA-chronological age difference, i.e., 10.74 years (SD = 4.19) compared to 6.00 years (SD = 3.10) in the non-user EUPD group (p < 0.00001). Notably, past alcohol and substance abuse, use of psychotropic medications, global assessment of functioning, self-reported exposure to violent behavior in youth and adulthood, later completed suicide (N = 8) and age at first suicide attempt did not predict EAA in the EUPD group (p > 0.05). These results underscore the importance of addressing medical health conditions along with low-cost preventative interventions aimed at improving somatic health outcomes in EUPD, such as efforts to support cessation of tobacco use. The independency of GrimAge to other EA algorithms in this group of severely impaired EUPD patients, suggest it may have unique characteristics to evaluate risk of adverse health outcomes in context of psychiatric disorders.
Reproducing extracellular matrix adverse remodelling of non-ST myocardial infarction in a large animal model
Authors: Contessotto Paolo , Spelat Renza , Ferro Federico , Vysockas Vaidas , Krivickienė Aušra , Jin Chunsheng , Chantepie Sandrine , Chinello Clizia , Pauza Audrys G. , Valente Camilla , Rackauskas Mindaugas , Casara Alvise , Zigmantaitė Vilma , Magni Fulvio , Papy-Garcia Dulce , Karlsson Niclas G. , Ereminienė Eglė , Pandit Abhay , Da Costa Mark 
Published: February 2023

AbstractThe rising incidence of non-ST-segment elevation myocardial infarction (NSTEMI) and associated long-term high mortality constitutes an urgent clinical issue. Unfortunately, the study of possible interventions to treat this pathology lacks a reproducible pre-clinical model. Indeed, currently adopted small and large animal models of MI mimic only full-thickness, ST-segment-elevation (STEMI) infarcts, and hence cater only for an investigation into therapeutics and interventions directed at this subset of MI. Thus, we develop an ovine model of NSTEMI by ligating the myocardial muscle at precise intervals parallel to the left anterior descending coronary artery. Upon histological and functional investigation to validate the proposed model and comparison with STEMI full ligation model, RNA-seq and proteomics show the distinctive features of post-NSTEMI tissue remodelling. Transcriptome and proteome-derived pathway analyses at acute (7 days) and late (28 days) post-NSTEMI pinpoint specific alterations in cardiac post-ischaemic extracellular matrix. Together with the rise of well-known markers of inflammation and fibrosis, NSTEMI ischaemic regions show distinctive patterns of complex galactosylated and sialylated N-glycans in cellular membranes and extracellular matrix. Identifying such changes in molecular moieties accessible to infusible and intra-myocardial injectable drugs sheds light on developing targeted pharmacological solutions to contrast adverse fibrotic remodelling.
Epidemiological impacts of the NHS COVID-19 app in England and Wales throughout its first year
Authors: Kendall Michelle , Tsallis Daphne , Wymant Chris , Di Francia Andrea , Balogun Yakubu , Didelot Xavier , Ferretti Luca , Fraser Christophe 
Published: February 2023

AbstractThe NHS COVID-19 app was launched in England and Wales in September 2020, with a Bluetooth-based contact tracing functionality designed to reduce transmission of SARS-CoV-2. We show that user engagement and the app’s epidemiological impacts varied according to changing social and epidemic characteristics throughout the app’s first year. We describe the interaction and complementarity of manual and digital contact tracing approaches. Results of our statistical analyses of anonymised, aggregated app data include that app users who were recently notified were more likely to test positive than app users who were not recently notified, by a factor that varied considerably over time. We estimate that the app’s contact tracing function alone averted about 1 million cases (sensitivity analysis 450,000–1,400,000) during its first year, corresponding to 44,000 hospital cases (SA 20,000–60,000) and 9,600 deaths (SA 4600–13,000).
Supramolecular framework membrane for precise sieving of small molecules, nanoparticles and proteins
Authors: Zhang Guohua , Li Xinyue , Chen Gang , Zhang Yue , Wei Mingfeng , Chen Xiaofei , Li Bao , Wu Yuqing , Wu Lixin 
Published: February 2023

AbstractSynthetic framework materials have been cherished as appealing candidates for separation membranes in daily life and industry, while the challenges still remain in precise control of aperture distribution and separation threshold, mild processing methods, and extensive application aspects. Here, we show a two-dimensional (2D) processible supramolecular framework (SF) by integrating directional organic host-guest motifs and inorganic functional polyanionic clusters. The thickness and flexibility of the obtained 2D SFs are tuned by the solvent modulation to the interlayer interactions, and the optimized SFs with limited layers but micron-sized areas are used to fabricate the sustainable membranes. The uniform nanopores allow the membrane composed of layered SF to exhibit strict size retention for substrates with the rejection value of 3.8 nm, and the separation accuracy within 5 kDa for proteins. Furthermore, the membrane performs high charge selectivity for charged organics, nanoparticles, and proteins, due to the insertion of polyanionic clusters in the framework skeletons. This work displays the extensional separation potentials of self-assembled framework membranes comprising of small-molecules and provides a platform for the preparation of multifunctional framework materials due to the conveniently ionic exchange of the counterions of the polyanionic clusters.
Non-covalent ligand-oxide interaction promotes oxygen evolution
Authors: Wu Qianbao , Liang Junwu , Xiao Mengjun , Long Chang , Li Lei , Zeng Zhenhua , Mavrič Andraž , Zheng Xia , Zhu Jing , Liang Hai-Wei , Liu Hongfei , Valant Matjaz , Wang Wei , Lv Zhengxing , Li Jiong , Cui Chunhua 
Published: February 2023

AbstractStrategies to generate high-valence metal species capable of oxidizing water often employ composition and coordination tuning of oxide-based catalysts, where strong covalent interactions with metal sites are crucial. However, it remains unexplored whether a relatively weak “non-bonding” interaction between ligands and oxides can mediate the electronic states of metal sites in oxides. Here we present an unusual non-covalent phenanthroline-CoO2 interaction that substantially elevates the population of Co4+ sites for improved water oxidation. We find that phenanthroline only coordinates with Co2+ forming soluble Co(phenanthroline)2(OH)2 complex in alkaline electrolytes, which can be deposited as amorphous CoOxHy film containing non-bonding phenanthroline upon oxidation of Co2+ to Co3+/4+. This in situ deposited catalyst demonstrates a low overpotential of 216 mV at 10 mA cm−2 and sustainable activity over 1600 h with Faradaic efficiency above 97%. Density functional theory calculations reveal that the presence of phenanthroline can stabilize CoO2 through the non-covalent interaction and generate polaron-like electronic states at the Co-Co center.
Investigating defects and annual degradation in UK solar PV installations through thermographic and electroluminescent surveys
Authors: Dhimish Mahmoud , Badran Ghadeer 
Published: February 2023

AbstractAs the adoption of renewable energy sources, particularly photovoltaic (PV) solar, has increased, the need for effective inspection and data analytics techniques to detect early-stage defects, faults, and malfunctions has become critical for maintaining the reliability and efficiency of PV systems. In this study, we analysed thermal defects in 3.3 million PV modules located in the UK. Our findings show that 36.5% of all PV modules had thermal defects, with 900,000 displaying single or multiple hotspots and ~250,000 exhibiting heated substrings. We also observed an average temperature increase of 21.7 °C in defective PV modules. Additionally, two PV assets with 19.25 and 8.59% thermal defects were examined for PV degradation, and results revealed a higher degradation rate when more defects are present. These results demonstrate the importance of implementing cost-effective inspection procedures and data analytics platforms to extend the lifetime and improve the performance of PV systems.
Inhibition of norepinephrine signaling during a sensitive period disrupts locus coeruleus circuitry and emotional behaviors in adulthood
Authors: Meng Qingyuan , Garcia-Garcia Alvaro L. , Dranovsky Alex , Leonardo E. David 
Published: February 2023

AbstractDeficits in arousal and stress responsiveness are a feature of numerous psychiatric disorders including depression and anxiety. Arousal is supported by norepinephrine (NE) released from specialized brainstem nuclei, including the locus coeruleus (LC) neurons into cortical and limbic areas. During development, the NE system matures in concert with increased exploration of the animal’s environment. While several psychiatric medications target the NE system, the possibility that its modulation during discreet developmental periods can have long-lasting consequences has not yet been explored. We used a chemogenetic strategy in mice to reversibly inhibit NE signaling during brief developmental periods and then evaluated any long-lasting impact of our intervention on adult NE circuit function and on emotional behavior. We also tested whether developmental exposure to the α2 receptor agonist guanfacine, which is commonly used in the pediatric population and is not contraindicated during pregnancy and nursing, recapitulates the effect seen with the chemogenetic strategy. Our results reveal that postnatal days 10–21 constitute a sensitive period during which alterations in NE signaling lead to changes in baseline anxiety, increased anhedonia, and passive coping behaviors in adulthood. Disruption of NE signaling during this sensitive period also caused altered LC autoreceptor function, along with circuit specific changes in LC-NE target regions at baseline, and in response to stress. Our findings indicate an early critical role for NE in sculpting brain circuits that support adult emotional function. Interfering with this role by guanfacine and similar clinically used drugs can have lasting implications for mental health.
Effects of exogenous oxytocin and estradiol on resting-state functional connectivity in women and men
Authors: Coenjaerts Marie , Adrovic Berina , Trimborn Isabelle , Philipsen Alexandra , Hurlemann René , Scheele Dirk 
Published: February 2023

AbstractPossible interactions of the neuropeptide oxytocin and the sex hormone estradiol may contribute to previously observed sex-specific effects of oxytocin on resting-state functional connectivity (rsFC) of the amygdala and hippocampus. Therefore, we used a placebo-controlled, randomized, parallel-group functional magnetic resonance imaging study design and measured amygdala and hippocampus rsFC in healthy men (n = 116) and free-cycling women (n = 111), who received estradiol gel (2 mg) or placebo before the intranasal administration of oxytocin (24 IU) or placebo. Our results reveal significant interaction effects of sex and treatments on rsFC of the amygdala and hippocampus in a seed-to-voxel analysis. In men, both oxytocin and estradiol significantly decreased rsFC between the left amygdala and the right and left lingual gyrus, the right calcarine fissure, and the right superior parietal gyrus compared to placebo, while the combined treatment produced a significant increase in rsFC. In women, the single treatments significantly increased the rsFC between the right hippocampus and the left anterior cingulate gyrus, whereas the combined treatment had the opposite effect. Collectively, our study indicates that exogenous oxytocin and estradiol have different region-specific effects on rsFC in women and men and that the combined treatment may produce antagonistic effects.
In vitro to clinical translational pharmacokinetic/pharmacodynamic modeling of doxorubicin (DOX) and dexrazoxane (DEX) interactions: Safety assessment and optimization
Authors: Mody Hardik , Vaidya Tanaya R. , Ait-Oudhia Sihem 
Published: February 2023

AbstractDespite high anticancer activity, doxorubicin (DOX)-induced cardiotoxicity (DIC) limits the extensive utility of DOX in a clinical setting. Amongst various strategies explored, dexrazoxane (DEX) remains the only cardioprotective agent to be approved for DIC. In addition, altering the dosing regimen of DOX has also proved to be somewhat beneficial in decreasing the risk of DIC. However, both approaches have limitations and further studies are required to better optimize them for maximal beneficial effects. In the present work, we quantitatively characterized DIC as well as the protective effects of DEX in an in vitro model of human cardiomyocytes, by means of experimental data and mathematical modeling and simulation (M&S) approaches. We developed a cellular-level, mathematical toxicodynamic (TD) model to capture the dynamic in vitro drug-drug interaction, and relevant parameters associated with DIC and DEX cardio-protection were estimated. Subsequently, we executed in vitro-in vivo translation by simulating clinical PK profiles for different dosing regimens of DOX alone and in combinations with DEX and using the simulated PK profiles to drive the cell-based TD models to evaluate the effects of long-term, clinical dosing regimens of these drugs on the relative cell viability of AC16 and to determine optimal drug combinations with minimal cellular toxicity. Here, we identified that the Q3W (once every three weeks) DOX regimen with 10:1 DEX:DOX dose ratio over three cycles (nine weeks) may offer maximal cardio-protection. Overall, the cell-based TD model can be effectively used to better design subsequent preclinical in vivo studies aimed for further optimizing safe and effective DOX and DEX combinations to mitigate DIC.
Improving the efficiency of dye-sensitized solar cells based on rare-earth metal modified bismuth ferrites
Authors: Khan Maham , Iqbal Muhammad Aamir , Malik Maria , Hashmi Syed Usama Mauood , Bakhsh Sunila , Sohail Muhammad , Qamar Muhammad Tariq , Al-Bahrani Mohammed , Capangpangan Rey Y. , Alguno Arnold C. , Choi Jeong Ryeol 
Published: February 2023

AbstractThis study reports light energy harvesting characteristics of bismuth ferrite (BiFeO3) and BiFO3 doped with rare-earth metals such as neodymium (Nd), praseodymium (Pr), and gadolinium (Gd) dye solutions that were prepared by using the co-precipitation method. The structural, morphological, and optical properties of synthesized materials were studied, confirming that 5–50 nm sized synthesized particles have a well-developed and non-uniform grain size due to their amorphous nature. Moreover, the peaks of photoelectron emission for bare and doped BiFeO3 were observed in the visible region at around 490 nm, while the emission intensity of bare BiFeO3 was noticed to be lower than that of doped materials. Photoanodes were prepared with the paste of the synthesized sample and then assembled to make a solar cell. The natural and synthetic dye solutions of Mentha, Actinidia deliciosa, and green malachite, respectively, were prepared in which the photoanodes were immersed to analyze the photoconversion efficiency of the assembled dye-synthesized solar cells. The power conversion efficiency of fabricated DSSCs, which was confirmed from the I–V curve, is in the range from 0.84 to 2.15%. This study confirms that mint (Mentha) dye and Nd-doped BiFeO3 materials were found to be the most efficient sensitizer and photoanode materials among all the sensitizers and photoanodes tested.
A fast vanishing point detection method based on row space features suitable for real driving scenarios
Authors: Yang Qin , Ma Yahong , Li Linsen , Gao Yujie , Tao Jiaxin , Huang Zhentao , Jiang Rui 
Published: February 2023

AbstractThe vanishing point (VP) is particularly important road information, which provides an important judgment criterion for the autonomous driving system. Existing vanishing point detection methods lack speed and accuracy when dealing with real road environments. This paper proposes a fast vanishing point detection method based on row space features. By analyzing the row space features, clustering candidates for similar vanishing points in the row space are performed, and then motion vectors are screened for the vanishing points in the candidate lines. The experimental results show that the average error of the normalized Euclidean distance is 0.0023716 in driving scenes under various lighting conditions. The unique candidate row space greatly reduces the amount of calculation, making the real-time FPS up to 86. It can be concluded that the fast vanishing point detection proposed in this paper would be suitable for high-speed driving scenarios.
Uncovering the complex genetic architecture of human plasma lipidome using machine learning methods
Authors: Lehtimäki Miikael , Mishra Binisha H. , Del-Val Coral , Lyytikäinen Leo-Pekka , Kähönen Mika , Cloninger C. Robert , Raitakari Olli T. , Laaksonen Reijo , Zwir Igor , Lehtimäki Terho , Mishra Pashupati P. 
Published: February 2023

AbstractGenetic architecture of plasma lipidome provides insights into regulation of lipid metabolism and related diseases. We applied an unsupervised machine learning method, PGMRA, to discover phenotype-genotype many-to-many relations between genotype and plasma lipidome (phenotype) in order to identify the genetic architecture of plasma lipidome profiled from 1,426 Finnish individuals aged 30–45 years. PGMRA involves biclustering genotype and lipidome data independently followed by their inter-domain integration based on hypergeometric tests of the number of shared individuals. Pathway enrichment analysis was performed on the SNP sets to identify their associated biological processes. We identified 93 statistically significant (hypergeometric p-value < 0.01) lipidome-genotype relations. Genotype biclusters in these 93 relations contained 5977 SNPs across 3164 genes. Twenty nine of the 93 relations contained genotype biclusters with more than 50% unique SNPs and participants, thus representing most distinct subgroups. We identified 30 significantly enriched biological processes among the SNPs involved in 21 of these 29 most distinct genotype-lipidome subgroups through which the identified genetic variants can influence and regulate plasma lipid related metabolism and profiles. This study identified 29 distinct genotype-lipidome subgroups in the studied Finnish population that may have distinct disease trajectories and therefore could be useful in precision medicine research.