bluuebunny/crossref_metadata_2025_split huggingface dataset:
PERSEPSI KONSUMEN TERKAIT ETIKA, KEPUASAN DAN LOYALITAS PELANGGAN DI SEKTOR RETAIL ONLINE
Authors: Halim Muthia Agnisa , Sari Lola Fitria , Nofranita Willy 
Published: May 2023

Penelitian ini bertujuan untuk menguji pengaruh persepsi konsumen terkait etika pengecer online (CPEOR), e-satisfaction terhadap e-loyalty pelanggan di sektor retail online. Jenis penelitian ini adalah kuantitatif, metode penelitian menekankan pada pengukuran hasil yang objektif dengan menggunakan analisis Structural Equation Model (SEM). Populasi dalam penelitian ini adalah Tenaga Kerja Wanita yang bekerja di sektor formal Kota Padang. Adapun jumlah sampel dalam penelitian ini sebanyak 170 orang yang didapat dengan menggunakan estimasi interpretasi dengan rumus penentuan jumlah sampel maksimum untuk SEM. Jenis data yang digunakan dalam penelitian ini adalah data kuantitatif.Sedangkan sumber datanya adalah sumber data primer.Teknik analisis data dengan teknik statistik Structural Equation Model (SEM) dengan menggunakan bantuan program STATA 14.0. Hasil penelitian ini menunjukan bahwa CPEOR dan e-satisfaction berpengaruh signifikan dan positif terhadap e-loyalty pelanggan di sektor retail online.Kata Kunci : Persepsi Konsumen Terkait Etika Pengecer Online (CPEOR), (E-Satisfaction) Dan Loyalitas Pelanggan (E-Loyalty).
PENERAPAN ALGORITMA K-MEANS UNTUK PENGELOMPOKKAN PENILAIAN AKHIR SEMESTER DI SDN KADOKAN 01 SUKOHARJO
Authors: Ningrum Karlina Kusuma , Maulindar Joni , Farida Anisatul 
Published: May 2023

Penilaian Akhir Semester (PAS) merupakan penilaian tahunan terhadap standar pendidikan. Penilaian Akhir Semester merupakan kinerja kompetensi semua mata pelajaran di Sekolah. Berdasarkan data hasil survei Penilaian Akhir Semester (PAS) yang dilakukan peneliti di SDN Kadokan 01 Sukoharjo, dimanainformasi yang diberikan tidak mencantumkan kelas tertentu, sehingga informasi yang diberikan kepada orang tua siswa kurang jelas. Berdasarkan permasalahan tersebut maka dilakukan sebuah penelitian dengan menggunakan nilai Penilaian Akhir Semester (PAS) di SDN Kadokan 01 Sukoharjo dengan menggunakan teknik data mining yaitu algoritma k-means clustering, mengelompokkan data menjadi beberapa cluster berdasarkan kesamaan data. Berdasarkan hasil penelitian teridendifikasi 3 cluster yaitu cluster 0 yang memiliki tingkat cluster rendah pada nilai penilaian akhir semester sebanyak 43 siswa, cluster 1 dengan tingkat cluster sedang sebanyak 62 siswa, dan cluster 2 dengan tingkat cluster tinggi sebanyak 63 siswa.
19. YÜZYIL TEKİRDAĞ SİLÜETİNİ SÜSLEYEN SAAT KULESİ VE TARİHİ SERÜVENİ
Authors: SIRIM Veli 
Published: May 2023

19. yüzyıl sonlarına ait Tekirdağ fotograflarına, kartpostallarına ve çizimlerine bakıldığında, şehir silüetini şekillendiren en önemli eserlerden birisinin Saat Kulesi olduğu görülecektir. Kanuni dönemine ait en önemli tarihi eser olan Rüstem Paşa Camii’nin hemen yanında yer alan Saat Kulesi, tarihî kaynaklara ve hatırat türü eserlere göre 1800’lü yılların hemen başında, dönemin Tekfurdağı Âyânı (yöneticisi) Çelebi Süleyman Ağa tarafından yaptırılmıştır. 1912 yılında meydana gelen Mürefte Depremi’nde büyük hasar gören Saat Kulesi, kısa zamanda yıkılmıştır.
Bu makalede, 19. yüzyıl boyunca Tekirdağ silüetinin en önde gelen unsurları arasında yer alan Saat Kulesi hakkında bilgi verilecektir. Aynı zamanda, resimlerdeki görünümünden hareketle, aslına uygun olarak yeniden inşa edilmesi halinde şehrin tarihi kimliğine ve mirasına önemli katkı yapılacağı üzerinde durulacaktır.
TANZİMAT DÖNEMİNDE RUMELİ KAZASKERLERİ (1839-1861)
Authors: ALTUNTAŞ Zeynep 
Published: May 2023

Kazaskerlik, Osmanlı Devleti’nin ilk dönemlerinden itibaren ilmiye sınıfının mühim görevlerinden biri olmuştur. Osmanlı’nın erken dönemlerinde birden fazla olduğu anlaşılan kazaskerlerin daha sonra Rumeli ve Anadolu kazaskerliği olarak ikiye ayrıldığı görülmektedir. Klasik dönemde Divan-ı Hümayun üyesi de olan kazaskerler modern dönemde ilmiye sınıfının zirvesi olan şeyhülislamlıktan bir önceki basamakta yer almışlardır. Zaman zaman itibarında ve buna bağlı olarak yetkilerinde artışlar veya eksilmeler olan kazaskerlerin en bilinen görevleri kadılık makamının başında olması sebebiyle yargılama görevi, kadıları ve müderrisleri tayin, teftiş ve azl etmeleridir.
Bu çalışmada rütbesi Anadolu kazaskerlerinden yüksek ve dolayısıyla ilmiye mesleğinin başı olan şeyhülislamlığa geçişte şansı daha fazla olan Rumeli kazaskerleri incelendi. Bu yapılırken kazaskerliğin itibarlı bir memuriyet haline geldiği Tanzimat döneminin zirvesi denebilecek Sultan Abdülmecid döneminde (1839-1861) kazaskerliğe başlayanlar seçildi. Prosopografi yöntemi kısmen kullanılarak kazaskerlerin aile bağları, ailelerin mesleki kökenleri yani sosyal kökenleri ortaya konuldu. Çoğu ilmiyeden ve önemli ailelere mensup kazaskerlerin yanında başka meslek guruplarından olduğu düşünülen ailelere sahip kazaskerlere de vurgu yapıldı. Ayrıca kazaskerlerin bu göreve tayinleri, görev süreleri ve görev sürelerinin uzatılması gibi konular incelendi. Tüm bunlar klasik ve modern dönem kazaskerlik yapısı karşılaştırılarak, farklılıklar ve benzerlikler ortaya konularak yapıldı.
Analisis Literatur Sistematik Terhadap Penentuan Agihan Bantuan Kemiskinan Kepada Golongan B40 Di Malaysia
Authors: Sukari Afaf , Ab Rahman Azman , Abd Shakor Muhammad Faiz , Syed Shamsuddin Syed Salim , Mohd Yusof Zizi Azlinda 
Published: May 2023

Kenaikan insiden kemiskinan mutlak di Malaysia semakin meningkat apabila 20% isi rumah M40 beralih kepada B40 sepanjang waktu pandemik COVID-19 akibat kemelesetan ekonomi. Pelbagai usaha dijalankan bagi menangani kemiskinan sejajar dengan tunjang utama Rancangan Malaysia Kedua Belas (RMK-12) iaitu pengukuhan keselamatan, kesejahteraan dan inklusiviti. Bagi mencapai objektif kesejahteraan negara dalam masa lima tahun sejak RMK-12 diperkenalkan, pendekatan yang proaktif perlu dilakukan secara terancang. Namun begitu, pelbagai pendapat telah dilontarkan bagi mentransformasikan inklusiviti B40 dalam kegiatan ekonomi terutamanya berkaitan agihan bantuan kemiskinan yang menjadi talian hayat mereka saban hari. Oleh itu, penilaian semula penentu agihan bantuan kemiskinan perlu dijalankan bagi memastikan kesejahteraan rakyat terus terjamin. Kajian ini dilakukan adalah untuk menganalisis berkenaan penentuan agihan bantuan kemiskinan kepada golongan B40 di Malaysia dengan menggunakan analisis literatur sistematik. Kajian ini menggunakan kaedah PRISMA iaitu dengan membuat carian artikel di pangkalan data Scopus dan My Jurnal secara sistematik sepanjang tempoh bermula 2021 hingga 2023. Data yang dikumpul telah dianalisis dan direkodkan dalam carta alir PRISMA. Sejumlah 52 artikel jurnal yang terpilih berkaitan dengan topik telah dibincangkan oleh pengkaji. Hasil kajian mendapati agihan bantuan kemiskinan yang baru mampu mengenalpasti faktor tekanan sara hidup rakyat miskin yang terjerat dalam golongan B40 selain membantu untuk meringankan beban kuasa ekonomi rakyat miskin. Diharapkan penyelidikan ini dapat memberi gambaran dan perbincangan yang berguna serta menjadi rujukan kepada penyelidik dan ahli akademik yang lain berkenaan analisis sistematik terhadap penentuan agihan bantuan kemiskinan kepada golongan B40 dengan menggunakan metodologi PRISMA.
Kerangka Konseptual Model Gelagat Pemberian Hibah Di Malaysia
Authors: Abd Latib Noor Aznaim , Riffin Mohd Khairul Izwan 
Published: May 2023

Ilmu pengetahuan, kesedaran dan sikap merupakan di antara faktor yang mendorong kepada amalan perancangan harta. Namun, masih ramai masyarakat yang tidak menyedari tentang keperluan dan kepentingan pengurusan harta. Dianggarkan sebanyak 95 peratus umat Islam masih tidak sedar berkaitan kepentingan menguruskan harta semasa hidup. Perkara sebegini merupakan sesuatu yang sangat merisaukan kerana harta pusaka yang tidak diuruskan dengan sebaiknya akan mengundang kepada implikasi negatif dari segi undang-undang, ekonomi dan sosial. Justeru, adalah sangat penting untuk memahami faktor-faktor seperti faktor tahap pengetahuan, kesedaran dan sikap yang mempengaruhi masyarakat Islam supaya mereka sedar akan kepentingan pengurusan hartanah. Oleh itu, tujuan kajian ini dilaksanakan bagi mencadangkan satu model untuk mengukur gelagat pemberi hibah berdasarkan kepada Teori Tindakan Bersebab (TBK). Selain itu, kajian ini dapat membantu institusi terlibat sama ada melibatkan pihak kerajaan mahupun swasta bagi merangka strategi dan dasar tertentu bagi menggalakkan umat Islam melaksanakan hibah. Kedua, kajian ini juga dilihat dapat membantu dalam memahami sebab masyarakat Islam masih kurang merancang harta melalui hibah. Metodologi kajian ini berbentuk kualitatif menggunakan kaedah analisa isi kandugan. Artikel ini telah membincangkan keperluan untuk meneroka dengan lebih mendalam mengenai gelagat pemberi hibah yang diwujudkan bagi menyelesaikan masalah harta pusaka yang tidak diurus dengan baik. Hasil dari analisa kandungan yang dijalankan, tiga hipotesis telah dicadangkan bagi melihat hubungan di antara tahap pengetahuan, kesedaran dan sikap dengan gelagat pemberi hibah. Kajian ini diharapkan dapat membantu institusi terlibat sama ada melibatkan pihak kerajaan mahupun swasta bagi merangka strategi dan dasar tertentu bagi menggalakkan masyarakat Islam melaksanakan hibah.
Are calcium channel blockers related to lung cancer?
Authors: Rattanathanoo Ratchanon , Chindaprasirt Jarin , Boonsawat Watchara , Limpawattana Panita , Khamsai Sittichai , Sawanyawisuth Kittisak 
Published: May 2023

Background: Calcium channel blocker (CCB) is a common antihypertensive agent for the treatment of hypertension. There are inconsistent data of an association of CCB and lung cancer in the literature. This study aimed to evaluate this association by a case-control design.
Methods: The inclusion criteria were adult patients 18 years or over, diagnosed with hypertension, lung cancer or pulmonary tuberculosis, and presenting with one of the suggestive symptoms of lung cancer. Those who were pregnant or had a diagnosis of lung cancer or pulmonary tuberculosis prior to the diagnosis of hypertension were excluded. Diagnosis of lung cancer was made pathologically, while tuberculosis was made by positive acid-fast bacilli on sputum examination, sputum culture positive for Mycobacterium tuberculosis, or polymerase chain reaction positive for M. tuberculosis with a chest x-ray compatible with tuberculosis. Cases were those diagnosed with lung cancer, while controls were those diagnosed with tuberculosis. Factors associated with lung cancer were calculated by logistic regression analysis.
Results: There were 178 patients who met the study criteria. Of those, 69 patients (38.8%) were in the case group. The lung cancer group had EGFR gene mutation in 21 patients (52.5%) and adenocarcinoma was the most common cell type of lung cancer (55 patients; 79.7%). There were two factors independently associated with lung cancer including dyslipidemia and family history of lung cancer.
Conclusions: CCB was not associated with lung cancer in patients with hypertension but dyslipidemia and family history of lung cancer were independently associated with lung cancer in this setting.
1939 ERZİNCAN DEPREMİ'NİN ARTÇI SARSINTILARI: HABER-AKŞAM POSTASI
Authors: TÜRKKAN TUNALI Yasemin 
Published: May 2023

Yakın dönem Türkiye tarihinin en büyüğü olan 1939 yılı Erzincan merkezli 7,9 Ms büyüklüğündeki deprem, sebep olduğu can kaybı ve yıkımla bütün ülkede derin yankılar uyandırmıştır. Tüm Türk basınında olduğu gibi Haber-Akşam Postası’nda da geniş yer bulan deprem, ilk başta etkilediği diğer il ve ilçelerin ve buradaki zayiatın tespiti üzerine haberlerle konu edilmiştir. Çetin hava muhalefeti nedeniyle deprem bölgesiyle iletişim ve ulaşımda birçok güçlüğün yaşandığı bu ilk günlerde devlet ve hükümet yetkililerince gerek kurtarma ve ilk yardım çalışmaları için alınan tedbirler, gerekse depremzedelerin iaşesi için TBMM inisiyatifi ve Kızılay aracılığıyla yapılan aynî ve nakdî yardım seferberliğine dair gelişmelere yer verilmiştir. Aynı günlerde Marmara ve Ege’de peş peşe yaşanan sel baskınları, deprem bölgesine sevk edilen yardımların ulaşımını sekteye uğrattığı gibi, depremzedeler için yapılan girişimlerin bir kısmının selzedelere de ayrılmasını gerektirmiştir. Bir yandan depremzedelere yardım sevkiyatının, diğer yandan yol açma çalışmalarının devam ettiği bir sırada Haber-Akşam Postası gazetesi henüz ulaşılamayan ilçe ve köylerdeki depremzedelerin kötü koşullarını ve müdahaledeki gecikmeler nedeniyle ölümlerin arttığını vurgulayan manşet ve haberler yayınlamaya başlamıştır. Depremden bir ay kadar sonra eleştiri düzeyini arttıran gazete, geç ulaşılan köylerde, gecikmeli olarak yapılan müdahaleler, gönderilen yardımların yetersizliği, bazı görevlilerin sorumsuz davranışları, yardım teşkilatlanmasındaki eksiklikler üzerine sorgulayıcı ve hatta suçlayıcı haber ve yazılara yer vermiştir. Bu tür yayınlarını belge, fotoğraf ve söylentilerle desteklemeye çalışan gazete, özellikle toplanan bağışların akıbeti ve resmi olarak verilen bilgilerin güvenilirliği konusunda kamuoyunda şüphe uyandırmaya çalışmıştır. Gazete son olarak, bu yayınlarına konu olan durumların ve kişilerin birkaç örnekle sınırlı olduğunu kabul etmiş, deprem sonrası yapılan yardım çalışmalarının genelini töhmet altında bıraktığı suçlamalarını ise reddetmiştir.
Anahtar Kelimeler: 1939 Erzincan Depremi, Milli Yardım Komitesi, Kızılay, ilk yardım, müdahale, eleştiri, Haber-Akşam Postası.
Apocynaceae de Vitória da Conquista, Bahia
Authors: Azevedo Cecília Oliveira de , Rapini Alessandro 
Published: May 2023

Apresentamos aqui o levantamento das Apocynaceae de Vitória da Conquista, Bahia, Brasil. São reconhecidos 18 gêneros e 26 espécies nativas, incluindo 11 ocorrências novas para o município: Asclepias curassavica, Aspidosperma polyneuron, Blepharodon ampliflorum, Ditassa grandiflora, D. lenheirensis, Himatanthus bracteatus, Ibatia ganglinosa, Macropharynx peltata, Oxypetalum arachnoideum, Petalostelma dardanoi e Skytanthus hancorniifolius. Além disso, a identificação de Forsteronia thyrsoidea é atualizada para F. nitida.
Insights into the epigenetics of chronic rhinosinusitis with and without nasal polyps: a systematic review
Authors: Brar Tripti , Marks Lisa , Lal Devyani 
Published: May 2023

BackgroundEpigenetics facilitates insights on the impact of host environment on the genesis of chronic rhinosinusitis (CRS) through modulations of host gene expression and activity. Epigenetic mechanisms such as DNA methylation cause reversible but heritable changes in gene expression over generations of progeny, without altering the DNA base-pair sequences. These studies offer a critical understanding of the environment-induced changes that result in host predisposition to disease and may help in developing novel biomarkers and therapeutics. The goal of this systematic review is to summarize the current evidence on epigenetics of CRS with a focus on chronic rhinosinusitis with nasal polyps (CRSwNP) and highlight gaps that merit further research.MethodsA systematic review of the English language literature was performed to identify investigations related to epigenetic studies in subjects with CRS.ResultsThe review identified 65 studies. These have focused on DNA methylation and non-coding RNAs, with only a few on histone deacetylation, alternative polyadenylation, and chromatin accessibility. Studies include those investigating in vivo and in vitro changes or both. Studies also include animal models of CRS. Almost all have been conducted in Asia. The genome-wide studies of DNA methylation found differences in global methylation between CRSwNP and controls, while others specifically found significant differences in methylation of the CpG sites of the thymic stromal lymphopoietin (TSLP), IL-8, and PLAT. In addition, DNA methyltransferase inhibitors and histone deacetylase inhibitors were studied as potential therapeutic agents. Majority of the studies investigating non-coding RNAs focused on micro-RNAs (miRNA) and found differences in global expression of miRNA levels. These studies also revealed some previously known as well as novel targets and pathways such as tumor necrosis factor alpha, TGF beta-1, IL-10, EGR2, aryl hydrocarbon receptor, PI3K/AKT pathway, mucin secretion, and vascular permeability. Overall, the studies have found a dysregulation in pathways/genes involving inflammation, immune regulation, tissue remodeling, structural proteins, mucin secretion, arachidonic acid metabolism, and transcription.ConclusionsEpigenetic studies in CRS subjects suggest that there is likely a major impact of the environment. However, these are association studies and do not directly imply pathogenesis. Longitudinal studies in geographically and racially diverse population cohorts are necessary to quantify genetic vs. environmental risks for CRSwNP and CRS without nasal polyps and assess heritability risk, as well as develop novel biomarkers and therapeutic agents.
Compound danshen dripping pills vs. nitrates for stable angina pectoris: a systematic review and meta-analysis
Authors: Zhang Mengying , Wang Wenjia , Sun He , Zhai Jingbo , Hu Yunhui 
Published: May 2023

BackgroundLong-term use of nitrates for treating stable angina pectoris (SAP) may lead to patients' tolerance to nitrates. As a traditional Chinese medicine, Compound danshen dropping pills (CDDP) is beneficial for patients with SAP. This study aimed to critically assess the efficacy and safety of CDDP vs. nitrates for SAP.MethodsPubMed, Embase, Web of Science, Cochrane library, CNKI, Wanfang Digital Periodicals, and Chinese Science and Technology Periodicals database were searched from inception to April 2023. Randomized controlled trials (RCTs) comparing CDDP with nitrates for SAP were included. The meta-analysis was conducted to estimate the pooled effect.ResultsTwenty-nine studies were included for the statistical analysis. The meta-analyses with the random-effect model indicated that CDDP could significantly increase the effective rate in symptom improvement compared with nitrates (Pooled 9 RCTs, OR = 1.95, 95% CI: 1.25–3.05, P = 0.003, duration of 4 weeks; Pooled 4 RCTs, OR = 3.45, 95% CI: 1.84–6.48, P = 0.0001, duration of 6 weeks; Pooled 13 RCTs, OR = 4.02, 95% CI: 2.14–7.57, P &lt; 0.0001, duration of 8 weeks). The meta-analyses with the random-effect model indicated that CDDP could significantly increase the effective rate in electrocardiogram improvement compared with nitrates (Pooled 5 RCTs, OR = 1.60, 95% CI: 1.02–2.52, P = 0.04, duration of 4 weeks; Pooled 3 RCTs, OR = 2.47, 95% CI: 1.60–3.82, P &lt; 0.0001, duration of 6 weeks; Pooled 11 RCTs, OR = 3.43, 95% CI: 2.68–4.38, P &lt; 0.00001, duration of 8 weeks). The incidence of adverse drug reactions in the CDDP group was lower than that in the nitrates group (Pooled 23 RCTs, OR = 0.15, 95% CI: 0.1–0.21, P &lt; 0.00001). The results of the meta-analyses with fixed-effect model were similar with above results. The levels of the evidence ranged from very low to low.ConclusionThe present study suggests that CDDP with the duration of at least 4 weeks can be considered as an alternative to nitrates for treating SAP. However, more high-quality RCTs are still needed to confirm these findings.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42022352888, identifier [CRD42022352888].
Corticotropin releasing factor-1 receptor antagonism associated with favorable outcomes of male reproductive health biochemical parameters
Authors: Khattab Ahmed , Charlton R. Will 
Published: May 2023

BackgroundDisruption in androgen profiles and testicular adrenal rest tumors in males with congenital adrenal hyperplasia (CAH) can negatively affect sexual activity and fertility. Adrenal hyperandrogenism suppresses gonadotropin secretion and testicular adrenal rest tumors (TARTS), despite being noncancerous lesions, cause obstructive azoospermia and impaired testosterone (T) production. Circulating T in men with uncontrolled CAH is often predominantly adrenal in origin, which is reflected in high androstenedione/testosterone ratios (A4/T). Therefore, decreased luteinizing hormone (LH) levels and an increased A4/T are markers of impaired fertility in these individuals.MethodsOral tildacerfont 200 to 1000 mg once daily (QD) (n=10) or 100 to 200 mg twice daily (n=9 and 7) for 2 weeks (Study 201), and 400 mg QD (n=11) for 12 weeks (Study 202). Outcomes measured changes from baseline in A4, T, A4/T, and LH.ResultsMean T levels increased in Study 201 from 375.5 ng/dL to 390.5 ng/dL at week 2 (n=9), 485.4 ng/dL at week 4 (n=4) and 420.7 ng/dL at week 6 (n=4). In Study 202, T levels fluctuated in the normal range from 448.4 ng/dL at baseline to 412.0 ng/dL at week 12. Mean LH levels increased in Study 201 from 0.68 IU/L to 1.59 IU/L at week 2 (n=10), 1.62 IU/L at week 4 (n=5) and 0.85 IU/L at week 6 (n=4). In Study 202, mean LH levels increased from 0.44 IU/L at baseline to 0.87 IU/L at week 12. Mean A4/T decreased across both studies. In Study 201, the mean A4/T changed from a baseline of 1.28 to 0.59 at week 2 (n=9), 0.87 at week 4 (n=4), and 1.03 at week 6 (n=4). In Study 202, the A4/T decreased from baseline of 2.44 to 0.68 at week 12. Four men were hypogonadal at baseline; all experienced improved A4/T and 3/4 (75%) reached levels &lt;1.ConclusionTildacerfont treatment demonstrated clinically meaningful reductions in A4 levels, and A4/T with concomitant increased LH levels indicating increased testicular T production. The data suggests improvement in hypothalamic-pituitary-gonadal axis function, but more data is required to confirm favorable male reproductive health outcomes.
Genetically predicted vitamin C levels significantly affect patient survival and immunotypes in multiple cancer types
Authors: Yuan Jing , Zhang Yu-hong , Hua Xin , Hong Hui-qi , Shi Wei , Liu Kun-xiang , Liu Ze-xian , Huang Peng 
Published: May 2023

BackgroundRecent observational studies and meta-analyses have shown that vitamin C reduces cancer incidence and mortality, but the underlying mechanisms remain unclear. We conducted a comprehensive pan-cancer analysis and biological validation in clinical samples and animal tumor xenografts to understand its prognostic value and association with immune characteristics in various cancers.MethodsWe used the Cancer Genome Atlas gene expression data involving 5769 patients and 20 cancer types. Vitamin C index (VCI) was calculated using the expression of 11 genes known to genetically predict vitamin C levels, which were classified into high and low subgroups. The correlation between VCI and patient overall survival (OS), tumor mutational burden (TMB), microsatellite instability (MSI), and immune microenvironment was evaluated, using Kaplan-Meier analysis method and ESTIMATE (https://bioinformatics.mdanderson.org/estimate/). Clinical samples of breast cancer and normal tissues were used to validate the expression of VCI-related genes, and animal experiments were conducted to test the impact of vitamin C on colon cancer growth and immune cell infiltration.ResultsSignificant changes in expression of VCI-predicted genes were observed in multiple cancer types, especially in breast cancer. There was a correlation of VCI with prognosis in all samples (adjusted hazard ratio [AHR] = 0.87; 95% confidence interval [CI] = 0.78–0.98; P = 0.02). The specific cancer types that exhibited significant correlation between VCI and OS included breast cancer (AHR = 0.14; 95% CI = 0.05–0.40; P &lt; 0.01), head and neck squamous cell carcinoma (AHR = 0.20; 95% CI = 0.07–0.59; P &lt; 0.01), kidney clear cell carcinoma (AHR = 0.66; 95% CI = 0.48–0.92; P = 0.01), and rectum adenocarcinoma (AHR = 0.01; 95% CI = 0.001–0.38; P = 0.02). Interestingly, VCI was correlated with altered immunotypes and associated with TMB and MSI negatively in colon and rectal adenocarcinoma (P &lt; 0.001) but positively in lung squamous cell carcinoma (P &lt; 0.05). In vivo study using mice bearing colon cancer xenografts demonstrated that vitamin C could inhibit tumor growth with significant impact on immune cell infiltration.ConclusionVCI is significantly correlated with OS and immunotypes in multiple cancers, and vitamin C might have therapeutic potential in colon cancer.