bluuebunny/crossref_metadata_2025_split huggingface dataset:
ACSM6 overexpression indicates a non-inflammatory tumor microenvironment and predicts treatment response in bladder cancer: results from multiple real-world cohorts
Authors: Li Zhiwei , Yao Yiyan , Qi Tiezheng , Wu Zuowei , Deng Dingshan , Liu Bolong 
Published: June 2023

Background: ACSMs play critical roles in lipid metabolism; however, their immunological function within the tumor microenvironment (TME) remains unclear, especially that of ACSM6. In this study, we investigate the latent effect of ACSM6 on bladder cancer (BLCA).Methods: Several real-world cohorts, including the Xiangya (in-house), The Cancer Genome Atlas (TCGA-BLCA), and IMvigor210 cohorts, with TCGA-BLCA cohort serving as the discovery cohort were compared. We investigated the potential immunological effects of ACSM6 in regulating the BLCA tumor microenvironment by analyzing its correlation with immunomodulators, anti-cancer immune cycles, immune checkpoints, tumor-infiltrating immune cells, and the T-cell inflamed score (TIS). Additionally, we assessed the precision of ACSM6 in predicting BLCA molecular subtypes and responses to several treatments using ROC analysis. To ensure the robustness of our findings, all results were confirmed in two independent external cohorts: the IMvigor210 and Xiangya cohorts.Results: ACSM6 expression was markedly upregulated in BLCA. Our analysis suggests that ACSM6 might have significant impact to promote the formation of a non-inflamed tumor microenvironment because of its negative correlation with immunomodulators, anticancer immune cycles, immune checkpoints, tumor-infiltrating immune cells, and the T-cell inflamed score (TIS). Additionally, high ACSM6 expression levels in BLCA may predict the luminal subtype, which is typically associated with resistance to chemotherapy, neoadjuvant chemotherapy, and radiotherapy. These findings were consistent across both the IMvigor210 and Xiangya cohorts.Conclusion: ACSM6 has the potential to serve as a valuable predictor of the tumor microenvironment phenotypes and treatment outcomes in BLCA, thereby contributing to more precise treatment.
Association between childhood trauma and mental health disorders in adolescents during the second pandemic wave of COVID-19, Chiclayo-Peru
Authors: Valladares-Garrido Mario J. , León-Figueroa Darwin A. , Dawson Franccesca M. , Burga-Cachay Stefany C. , Fernandez-Canani Maria A. , Failoc-Rojas Virgilio E. , Pereira-Victorio César Johan , Valladares-Garrido Danai , Inga-Berrospi Fiorella 
Published: June 2023

IntroductionThe COVID-19 pandemic has significantly affected mental health, with children and adolescents being particularly vulnerable. Evidence on the association between childhood trauma and mental health outcomes in schoolchildren during the pandemic is limited. This study aimed to evaluate this relationship in Chiclayo city, northern Peru, during the second wave of COVID-19.MethodsA cross-sectional secondary data study was conducted, measuring childhood trauma using the Marshall’s Trauma Scale, depressive symptomatology (PHQ-9), and anxiety symptomatology (GAD-7). Additional variables assessed were alcohol use (AUDIT), resilience (abbreviated CD-RISC), and socio-educational data. Prevalence ratios were estimated using generalized linear models.ResultsAmong 456 participants, 88.2% were female, with a mean age of 14.5 years (SD: 1.33). Depressive symptomatology prevalence was 76.3% (95%CI: 72.14–80.15) and increased by 23% in schoolchildren with childhood trauma (PR: 1.23; 95%CI: 1.10–1.37). Factors positively associated with depressive symptomatology included increasing age, seeking mental health help during the pandemic, and severe family dysfunction. Anxiety symptomatology prevalence was 62.3% (95%CI: 57.65–66.75) and increased by 55% in schoolchildren with childhood trauma (PR: 1.55; 95%CI: 1.31–1.85). Anxiety symptomatology was positively associated with mild, moderate, and severe family dysfunction.ConclusionSchoolchildren exposed to childhood trauma are at increased risk for depressive and anxiety symptoms. Monitoring the impact of the COVID-19 pandemic on adolescent mental health is vital. These findings can assist schools in establishing effective measures to prevent mental health outcomes.
Molecular epidemiological characteristics of SARS-CoV-2 in imported cases from 2021 to 2022 in Zhejiang Province, China
Authors: Zhou Biaofeng , Sun Yi , Mao Haiyan , Su Lingxuan , Lou Yihan , Yan Hao , Yao Wenwu , Chen Honghu , Zhang Yanjun 
Published: June 2023

BackgroundsThe coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been a global threat since 2020. The emergence of the Omicron variant in 2021, which replaced Delta as the dominant variant of concern, has had a significant adverse impact on the global economy and public health. During this period, Zhejiang Province implemented dynamic zeroing and focused on preventing imported cases. This study aimed to gain clear insight into the characteristics of imported COVID-19 cases in Zhejiang Province.MethodsWe conducted a systematic molecular epidemiological analysis of 146 imported cases between July 2021 and November 2022 in Zhejiang Province. Virus samples with cycle threshold (Ct) value less than 32 were performed next generation sequencing. Basing the whole genome sequence obtained after quality control and assembly of reads, the whole genome variation map and phylogenetic tree were constructed and further analyzed.ResultsOur study identified critical months and populations for surveillance, profiled the variation of various lineages, determined the evolutionary relationships among various lineages of SARS-CoV-2, and compared the results in Zhejiang with those obtained worldwide during this period.ConclusionThe continuous molecular epidemiological surveillance of imported cases of COVID-19 in Zhejiang Province during 2021 to 2022 is consistent with the global epidemic trend.
Trichoderma longibrachiatum Inoculation Improves Drought Resistance and Growth of Pinus massoniana Seedlings through Regulating Physiological Responses and Soil Microbial Community
Authors: Yu Cun , Jiang Xian , Xu Hongyun , Ding Guijie 
Published: June 2023

Drought stress poses a serious threat to Pinus massoniana seedling growth in southern China. Trichoderma species, as beneficial microorganisms, have been widely used in agriculture to enhance plant growth and drought tolerance, but the interaction mechanisms remain unclear. To investigate the effect of drought-resistant Trichoderma longibrachiatum inoculation on P. massoniana growth under drought stress, the plant physiological indicators and rhizosphere microbiome diversity were measured to identify Trichoderma-activated mechanisms. Trichoderma longibrachiatum inoculation significantly promoted P. massoniana growth under drought treatment, and enhanced nitrogen, phosphorus, and potassium absorption compared with those of non-inoculated seedlings. Trichoderma longibrachiatum treatment alleviated the damage to cell membranes and needle tissue structure, and significantly increased antioxidant enzyme activities, osmotic substance contents, and photosynthesis in P. massoniana in response to drought stress. Soil nutrient contents, activities of sucrase, phosphatase, and urease as well as the relative abundances of the dominant genera Burkholderia, Rhodanobacter, and Trichoderma were elevated in the rhizosphere soil of P. massoniana inoculated with T. longibrachiatum under drought stress. A network analysis showed that certain crucial dominant taxa driven by T. longibrachiatum inoculation, including Penicillium, Trichoderma, Simplicillium, Saitozyma, Burkholderia, Bradyrhizobium, Sinomonas, and Mycobacterium, had more correlations with other microorganisms in the soil. Trichoderma longibrachiatum enhanced P. massoniana seedling growth under drought stress by regulating physiological responses and soil microbial community.
On International Comparison of National Income Within the CMEA Framework
Authors: Ivanov Yu. N. 
Published: June 2023

The article considers the results and methods of international comparisons of national income carried out in the CMEA from 1959 to1988. It is noted that the results of these comparisons were used for solving problems related to the organization of economic cooperation within the CMEA. This goal was consistent with the methodology of bilateral comparisons of the national income of the USSR with each other CMEA countries. The ﬁnal results for each bilateral comparison were computed using the Fisher index formula. This procedure did not secure the transitivity of the results. Considerable attention was paid to selecting commodity representatives with prices for calculating purchasing power parities (PPPs). For this purpose, meetings of experts, who were well-versed in the technical characteristics of the selected commodity representatives, were convened: in some cases, commodity prices were adjusted to ensure their comparability. The biggest challenges emerged while securing price comparability for the following commodity representatives: machinery, equipment, and construction projects.The paper presents characteristics of GDP based on PPP comparison methodology carried out within the UN ICP framework. It ensured the comparison of UN ICP and the CMEA comparison methods. In particular, it is noted that GDP comparisons were carried out using multilateral methods of comparison, securing the transitivity of the computed indices. In addition to national income indicators of industrial and agricultural output, capital investments and consumption of the population were compared. The article contains two tables with results of comparisons of national income of the CMEA countries, which were initially classiﬁed.
Russian Economy in 2022–2024: Results, Trends, Forecasts
Authors: Frenkel A. A. , Tikhomirov B. I. , Surkov A. A. 
Published: June 2023

The article discusses the results of the socio-economic development of Russia in 2022 and highlights trends and forecasts of the dy namics of macroeconomic indicators for 2023–2024. At the same time, the main challenges and threats are analyzed, including production, trade, economic, financial, monetary, infrastructural, logistical and other restrictions that have become the main instruments of the West’s sanctions wars against Russia in the new geopolitical reality associated with Russia’s conducting a special military operation (SMO).The main objects of analysis are the current state, trends, risks and threats to the Russian economy, the dynamics of industrial production, prices, inﬂation and foreign trade. It is noted that, despite the toughening of challenges, sanctions and threats in 2022, the macroeconomic results of 2022 turned out to be higher than oﬃcial forecasts and experts' expectations. This made it possible to substantiate the main conclusion of the study that the Russian economy managed to prevent a collapse and ﬁnd additional opportunities to better unlock the potential of economic growth and social progress in the current three-year period of 2023–2025 and in the long term. According to the authors, the need to further transform and improvethe eﬃciency of the Russian economy is predetermined not only by current but also, possibly, future challenges.
Pengaruh Penyuluhan Kesehatan Tanda Bahaya Kehamilan Pada Ibu Hamil
Authors: Yuli Bahriah  , Mardalena  
Published: June 2023

Kehamilan merupakan proses yang normal dan alamiah pada seorang wanita dimana dalam masa kehamilanterjadi perubahan fisik, psikologis dan sosial.Pengetahuan tentang tanda bahaya kehamilan merupakan halyang penting untuk diketahui oleh masyarakat, khususnya ibu hamil karena apabila tanda-tanda bahayatersebut diketahui sejak dini, maka penanganan akan lebih cepat.Tujuan penelitian ini untuk mengetahuiperbedaan tingkat pengetahuan ibu hamil tentang tanda bahaya kehamilan sebelum dan sesudah diberikanpenyuluhan di Posyandu Al Hijrah.Metode penelitian ini menggunakan penelitian kuantitatif dengan pendekatan cross sectional. Populasi dalam penelitian ini tercatat sebanyak 50 orang dan sampelnya sebanyak30 ibu hamil dengan teknik random sampling. Analisis univariat menggunakan distribusi frekuensi dan analisis bivariatnya dengan uji chi square. Hasil penelitian menunjukkan bahwa Setelah diberikan materi tanda bahaya kehamilan diperoleh jumlah ibu hamil yang mempunyai pengetahuan baik sebanyak 23 orang (76,7%) dan berpengetahuan cukup 7 orang (23.7%), dengan nilai rata-rata pre test 9,90 menjadi 12,87 saat post test. Dari penelitian ini bahwa didapatkan pengaruh baik dari penyuluhan tanda bahaya kehamilan pada penyuluhan ini. Kesimpulan hasil penelitian ini bahwa ada perbedaan yang signifikan pengetahuan ibu hamil sebelum dan sesudah diberikan penyuluhan kesehatan tentang tanda bahaya kehamilan pada ibu hamil di Posyandu Al Hijrah. Saran diharapkan kepada pihak Posyandu Al Hirah dapat lebih memfasilitasi informasi tentang tanda bahaya kehamilan kepada ibu hamil pada saat kunjungan antenatal care, guna untuk menambah pengetahuan ibu hamil.
Hubungan antara Dukungan Petugas KB dan Dukungan Suami dengan Pemilihan Metode Kontrasepsi Pil
Authors: Taufik Kurrohman  , Maria Septiana  , Ana Sapitri  
Published: June 2023

Hasil Pendataan Keluarga Tahun 2021, pemakaian cara/ alat
KB di Indonesia sebesar 57,4% di antara penggunaan KB
modern tersebut, sebagian besar masih sedikit yang
menggunakan cara KB pil (15,8%), dan merupakan
penyumbang terbesar pada kelompok Non MKJP dan jenis
hormonal. Data dari Puskesmas Cambai Kota Prabumulih
menunjukkan jumlah KB aktif yang memakai alat kontrasepsi
pil dari tahun 2020 sampai 2022 mengalami penurunan.
Penelitian ini bertujuan untuk mengetahui hubungan antra
dukungan petugas KB dan dukungan suami dengan pemilihan
metode kontrasepsi pil. Variabel independen pada penelitian
ini adalah dukungan petugas KB, dan dukungan suami
dihubungkan dengan pemilihan metode kontrasepsi pil
diwilayah kerja Puskesmas cambai Kota Prabumulih.
Penelitian ini menggunakan metode analitik dengan desain
cross sectional. Dilakukan selama satu semester, Populasi
penelitian semua PUS aktif diwilayah kerja Puskesmas
cambai berjumlah 1.654 orang dengan sampel 94. Hasil
penelitian ini menunjukkan diketahuinya ada hubungan yang
bermakna yaitu variabel dukungan petugas KB dengan p
Value = 0,016, sedang kan variabel yang tidak berhubungan
adalah dukungan suami dengan p Value= 0,248. Rekomendasi
pada penelitian ini adalah kepada petugas KB dapat membuat
perencanaan program dalam hal peningkatan peran serta
masyarakat dalam program KB secara berkesinambungan,
melalui promosi kesehatan antara lain : penyuluhan mengenai
program KB , pemberian poster atau brosur tentang KB
Faktor-Faktor yang Berhubungan dengan Kejadian Abortus
Authors: Pipin Karlensi  , Siti Aisyah  , Merisa Riski  
Published: June 2023

Abortus merupakan pengeluaran hasil konsepsi yang terjadi pada
umur kehamilan kurang 20 minggu dan berat janin ≤ 500 gram.
Dampak dari abortus jika tidak mendapatkan penanganan
langsung yang cepat dan tepat akan menambah angka kematian
ibu. Tujuan penelitian diketahuinya faktor-faktor yang
berhubungan dengan kejadian abortus. Penelitian ini
menggunakan metode survey analitik dengan pendekatan survey
cross sectional. Penelitian dilakukan bulan Januari tahun 2021 di
Rumah Sakit Muhammadiyah Palembang Tahun 2021. Populasi
dalam penelitian ini adalah semua ibu hamil yang datang
memeriksakan kehamilannya di Rumah Sakit Muhammadiyah
Palembang pada bulan Januari tahun 2021, yang berjumlah 718
orang. Sampel pada penelitian ini adalah sebagian ibu hamil
dengan usia kehamilan 0-6 bulan yang beresiko abortus yang
datang memeriksakan kehamilannya di Rumah
Sakit
Muhammadiyah Palembang tahun 2021. Teknik pengambilan
sampel pada penelitian ini menggunakan sistematis random
sampling dan di dapatkan sampel 88 responden. Data yang
dikumpulkan dalam penelitian ini adalah data
sekunder
menggunakan ceklis dengan cara melihat dokumen Rekam
Medis family folder ibu hamil yang mengalami kejadian abortus
di RS Muhammadiyah Palembang pada Tahun 2021 yang
kemudian di analisis menggunakan analisis univariat dan
bivariate dengan uji Chi-Square. Hasil analisis Chi-Square
ditemukan hasil ada hubungan paritas (pvalue = 0,040) dan
umur ibu (pvalue = 0,036) dengan kejadian abortus, dan
tidak ada hubungan jarak kehamilan (pvalue = 0, 059)
dengan kejadian abortus. Diharapkan petugas kesehatan
dapat memberikan edukasi kepada ibu hamil tentang
kesehatan kehamilan, mencegah terjadinya abortus dan
tanda bahaya dalam kehamilan.
Pengembangan Instrumen Berpikir Kritis : Tutor Identifikasi Berfikir Kritis
Authors: Yuliastri Adisti , Damanik Annisa Fazila Sabrina , Vebrianto Rian 
Published: June 2023

Research instrument is an important factor in research where the truth of research results lies and determines conclusions. The aim of this study is to review valid, consistent and reliable instruments for critical thinking. In this study, critical thinking consists of five construct, namely : (1) Provide a simple explanation; (2) Development of basic skills; (3) Summary; (4) Provide a more detailed explanation; and (5) Deciding the next strategy. Designed as a survey research, it involved 50 respondents consisting of 3 experts/lectures, 5 teacher and 42 students who were selected by stratified sampling technique and random chance. Data were analyzed using SPSS Version 23.00 for Windows to test internal concistency using Cronbach Alpha. The results showed that all items in the questionnaire were valid and reliable, withan average high Cronbach’s Alpha realibility score (0.897 > 0.6) and each statement had a high score (0.784 to 0.890). Therefore, these numbers indicate that this study has developed a qualitative critical thinking toolkit. Kata kunci: Berpikir Kritis, Instrumen, Tutor
La prostitución en España y su limbo normativo: ¿Estado proxeneta o abolicionismo utópico?
Authors: Capa Santamaría Saray 
Published: June 2023

Desde tiempos inmemoriales, la sociedad ha considerado a la prostitución como el oficio más antiguo del mundo desde una perspectiva y un entendimiento de la cuestión, que situaba en un plano muy peyorativo a todas esas personas que se dedicaban a dicha actividad. El tratamiento de la prostitución debe pasar por un enfoque que sanee y depure la perspectiva social, entendiendo dicho fenómeno como una nueva forma de esclavitud del siglo XXI, que responde a una demanda ancestral: el deseo de quien quiere acceder a un cuerpo mediante el pago de un precio irrisorio, como si fuese cualquier corriente transacción mercantilista.
El silencio del Estado en España respalda la visión de la prostitución como un mal necesario, que siempre existirá si, como es el caso, se adopta por parte del mismo una postura cómoda de inacción y contemplación. En otras palabas, hace referencia a una postura que no valore el sufrimiento de las personas dedicadas a esta actividad que mueve millones de euros al día en nuestro país sin ningún tipo de regulación al respecto. Encontrar una orientación que satisfaga todos los puntos de vista, casuísticas y tipos de moralidad es una tarea arduamente complicada, hacia la cual poco a poco se van dirigiendo los tímidos pasos de los gobernantes.
En España, seguimos teniendo una dimensión alegal respecto al fenómeno de la prostitución, y aunque como se ha dicho, se intenta avanzar en la cuestión, por el momento seguimos sin salir de la zona gris. Por lo tanto, el objetivo de los ocho puntos de esta aportación es ofrecer al lector una visión general de una problemática sobre la cual predomina el silencio más absoluto, para que este pueda extraer una conclusión y una reflexión sobre la licitud de esta actividad, y que existiendo dinero de por medio, en nuestra sociedad, todo vale.
Patofisiologi dan Faktor Predisposisi yang Berhubungan dengan Omphalocele
Authors: Rarung Angel D. , Lampus Harsali F. , Prasetyo Eko 
Published: June 2023

Abstract: Omphalocele is one of the most common congenital abnormalities of the abdominal wall. In various countries, the incidence of omphalocele ranges from 1-3.8 per 10,000 pregnancies. This study aimed to determine the pathophysiology and predisposing factors associated with omphalocele. This was a literature review study. Literatures were obtained through several databases: Pubmed, ClinicalKey, and Google Scholar. The results showed 22 articles that fulfilled the inclusion criteria. The pathophysiology of omphalocele was when the abdominal organs herniate for an extended period of time, in results failing the intra-abdominal organs from returning to their normal position. Predisposing factors associated with omphalocele were divided into two aspects namely maternal and neonatal. In conclusion, the pathophysiology of omphalocele is still the same from year to year with the existing theory that there has not been a shift or discoveries. In contrast, for predisposing factors, several studies have reported new aspects of maternal and neonates about factors related to omphalocele.
Keywords: omphalocele; pathophysiology; predisposing factors

Abstrak: Omphalocele adalah salah satu kelainan kongenital dinding abdomen yang paling umum terjadi, Insiden omphalocele berkisar pada 1-3,8 per 10.000 kehamilan di berbagai negara. Penelitian ini bertujuan untuk mengetahui patofisiologi dan faktor predisposisi yang berhubungan dengan omphalocele. Jenis penelitian ialah suatu literature review. Literatur diperoleh melalui beberapa basis data yaitu Pubmed, ClinicalKey, dan Google Scholar. Hasil penelitian mendapatkan 22 artikel yang sesuai dengan kriteria inklusi. Patofisiologi omphalocele yaitu ketika terjadi herniasi fisiologis berkepanjangan dari organ abdomen sehingga terjadi kegagalan organ intraabdomen untuk kembali ke posisi normalnya. Faktor predisposisi yang berhubungan dengan omphalocele terbagi atas dua aspek yaitu maternal dan neonatus. Simpulan penelitian ini ialah patofisiologi dari omphalocele masih sama dari tahun ke tahun dengan teori yang ada dimana belum terjadi pergeseran atau penemuan baru sedangkan untuk faktor predisposisinya terdapat beberapa penelitian yang melaporkan hal baru terkait aspek maternal dan neonatus yang berhubungan dengan omphalocele.
Kata kunci: omphalocele; patofisiologi; faktor predisposisi
Pelatihan Peningkatan Keterampilan Administrasi Menggunakan Microsoft Excel Pada Siswa-siswi SMK Triguna 1956
Authors: Kusumawardani Ratna , Yulianawati  , Mohammad Syafrullah  , Purwanto Purwanto , Jan Everhard  
Published: June 2023

Penerapan Microsoft Office sudah banyak dilakukan pada semua bidang, salah satunya bidang akademis dalam pengolahan data administrasi pada sebuah SMK namun tidak semua peserta didik menguasai dalam penggunaan Microsoft Office khususnya Microsoft Excel. Institusi ini memiliki peran untuk mendidik para peserta didik yang siap untuk bekerja sesuai dengan skill yang dimilikinya dimana pada jaman sekarang amat sulit mencari sebuah pekerjaan jika tidak memiliki skill atau keterampilan. Untuk memumpuni hal tersebut, maka kami bekerjasama dengan SMK Triguna 1956 untuk melakukan pelatihan administasi bagi peserta didik menggunakan Microsoft Excel. Kegiatan ini bertujuan agar para peserta didik memiliki keterampilan dibidang teknologi khususnya dalam mengoperasikan Microsoft Excel sehingga dapat menjadi bekal untuk mencari pekerjaan. Pelatihan ini menerapkan metode praktikum dengan melibatkan 30 orang peserta didik yang dilaksanakan di Laboratorium Komputer Universitas Budi Luhur Jakarta. Berdasarkan hasil kuesioner yang diberikan kepada para peserta didik diakhir sesi pelatihan menunjukan yang memahami materi yang disajikan dengan presentase diatas 92%. Diharapkan hasil kegiatan ini dapat menambah keterampilan atau skill para peserta didik untuk melamar pekerjaan usai tamat sekolah.
Kata kunci : Administrasi, Microsoft Excel, Microsoft Office.