bluuebunny/crossref_metadata_2025_split huggingface dataset:
Energy skills as a driver to sustainable construction: current status, needs and proposed actions
Authors: Stojanovska-Georgievska Lihnida , Cerovsek Tomo , Funtik Tomas , Sandeva Ivana , Krleski Aleksandar , Spasevska Hristina , Ginovska Margarita 
Published: March 2023

During the last two decades, intensified actions toward energy efficiency in construction have provoked the implementation of a significant number of EU-funded and national projects that have developed knowledge in the field of energy-efficient (EE) design and construction of new and refurbished buildings. The current study contributes to state-of-the-art research of the best practices in the field of energy skills at the EU level. The methodology used comprised of desk research on the status of the development of energy skills in construction and business, the status of demand, the level of awareness, and the current training schemes and certifications which are offered. The research is based on published reports, publications, and surveys, resulting in the identification of over 500 sources of information relevant to EE skills. Key findings address the challenges related to the transition of EE skills from the national to the inter-regional level, due to methodological differences, language barriers, and organizational issues. Special attention is given to identifying existing practices for the recognition of previous learning (RPL), and to mitigate barriers to further implementation of this method for upskilling and certification of professionals and workers. In addition, we provide a base that shall allow us to evaluate the impact of existing initiatives on EE and digital skills management in the construction sectors through the survey conducted on an inter-regional level, including five different European countries. The survey results show regional divergence in the adoption of energy skills, but also concentrate on more general conclusions that will pave the way for the creation of upcoming training schemes for upskilling of the construction workforce involving both blue collars and white collars, and noting digital skills, cross-craft competences, and skills in renewable sources as the most in-demand to ensure sustainable construction
Diabetes in the context of dental treatment in an interdisciplinary approach
Authors: Cabon Julia , Pejas Julia , Zawilska Anna , Trzcionka Agata 
Published: March 2023

Instroduction: Diabetes, including its numerous complications, is one of fundamental challenges of modern medicine. Over the years, many types of this disease have been appointed, differing in both etiological background and method of treatment.
Dentists, when providing dental care to a patient burdened with diabetes, should pay special attention to the first symptoms reported by the patient as well as manifested in the oral cavity and surrounding tissues, e.g. in the form of xerostomia, hypertrophy of the salivary glands, changes on mucous membranes, impeded healing, or difficulties in combating local inflammation and infections, as well as in the form of physiological microflora disorders.
Aim of the study: The aim of the study is to emphasize the need for controlling diabetes for the sake of general and oral health.
Materials and methods: Our work is mainly based on the articles published in PubMed, websites or medical books. We were looking for keywords such as ‘diabetes’, ‘dental treatment’, ‘symptoms of diabetes’ or ‘oral cavity diseases’.
Results: Diabetes is often manifested by changes in the oral cavity, as evidenced by numerous scientific studies presented in the bibliography. Controlling the disease helps to eliminate lowering quality-of-life general symptoms and oral lesions.
Conclusions: Faced with the challenges of modern medicine, the dentist is obliged to inform the patient about the diagnostic and therapeutic possibilities of both diabetes itself and its symptoms occurring in the oral cavity and then take all steps to ensure that the patient's condition is stabilised.
Admission of kidney patients to a closed staff nephrology department results in a better short-term survival
Authors: Schwartz Lihi , Rosenshtok Omer , Shalev Leah , Schneider Ella , Basok Anna , Vorobiov Marina , Romanjuk Elvira , Rogachev Boris , El-Sayed Ismail , Schwartz Lina , Menashe Idan , Regev Ohad , Haviv Yosef S. 
Published: March 2023

Background
The outcome of patients with chronic kidney disease (CKD) and acute kidney injury (AKI) is often dismal and measures to ameliorate their course are scarce. When admitted to the hospital, kidney patients are often hospitalized in general Medicine wards rather than in a specialized Nephrology department. In the current study, we compared the outcome of two cohorts of kidney patients (CKD and AKI) admitted either to general open-staff (with rotating physicians) Medicine wards or to a closed-staff (non-rotating Nephrologists) Nephrology ward.

Methods
In this population-based retrospective cohort study, we enrolled 352 CKD patients and 382 AKI patients admitted to either Nephrology or General Medicine wards. Short-term (< = 90 days) and long-term (>90 days) outcomes were recorded for survival, renal outcomes, cardiovascular outcomes, and dialysis complications. Multivariate analysis was performed using logistic regression and negative binomial regression adjusting to potential sociodemographic confounders as well as to a propensity score based on the association of all medical background variables to the admitted ward, to mitigate the potential admittance bias to each ward.

Results
One hundred and seventy-one CKD patients (48.6%) were admitted to the Nephrology ward and 181 (51.4%) were admitted to general Medicine wards. For AKI, 180 (47.1%) and 202 (52.9%) were admitted to Nephrology and general Medicine wards, respectively. Baseline age, comorbidities and the degree of renal dysfunction differed between the groups. Using propensity score analysis, a significantly reduced mortality rate was observed for kidney patients admitted to the Nephrology ward vs. general Medicine in short term mortality (but not long-term mortality) among both CKD patients admitted (OR = 0.28, CI = 0.14–0.58, p = 0.001), and AKI patients (or = 0.25, CI = 0.12–0.48, p< 0.001). Nephrology ward admission resulted in higher rates of renal replacement therapy (RRT), both during the first hospitalization and thereafter.

Conclusions
Thus, a simple measure of admission to a specialized Nephrology department may improve kidney patient outcome, thereby potentially affecting future health care planning.
Ang1 and Ang4 differentially affect colitis and carcinogenesis in an AOM-DSS mouse model
Authors: Hu Alexander , Roberts Cullen , Moscalu Andrei , Redston Mark , Yoo James 
Published: March 2023

Introduction
Angiogenin-1 (Ang1) and angiogenin-4 (Ang4) are 14-kDa ribonucleases with potent angiogenic and antimicrobial properties. The role of Ang1 and Ang4 in chronic colitis and colitis-associated cancer has not been previously studied.

Methods
Wild-type (WT) and angiogenin-1 knock-out (Ang1-KO) C57BL/6 mice were given azoxymethane, a colon carcinogen, 2 days in advance of three cycles of 3.5% dextran sodium sulfate (DSS). Disease activity index (DAI) was recorded, a colonoscopy was performed after each DSS treatment, and mice were euthanized (colitis, recovery, cancer) with tissue evaluated by histopathology. Ang1, Ang4, TNF-α, Il-1F062, IL-6, IL-10, IL-23, IL-33 mRNA levels were analyzed by RT-PCR.

Results
Ang1-KO mice exhibited more severe colitis compared to WT mice during both the acute (P<0.05) and recovery (P<0.05) phases of each DSS cycle. Consistent with these results, colonic TNF-α, IL1-β, IL-6, IL-10, and IL-33 mRNA levels were significantly upregulated in Ang1-KO mice (P<0.05). While Ang4 increased to similar levels in both WT and Ang1-KO mice during colitis and recovery phases, WT mice were distinguished by a significant upregulation of Ang1. Interestingly, despite the reduced colitis, WT mice developed significantly more tumors compared to Ang1-KO mice (P<0.05). 134 tumors formed in WT mice (4.6 tumors/mouse) while only 46 tumors formed (1.5 tumors/mice) in Ang1-KO mice, which were also characterized by a 34-fold decrease in Ang4 compared to WT mice and the complete absence of Ang1.

Conclusions
In a mouse model of colitis-associated cancer, Ang1-KO mice develop more severe colitis, but fewer tumors compared to WT mice. Ang1 levels correlate with the severity of colitis and the development of colitis-associated cancer, while Ang4 was upregulated during both colitis and cancer. Ang1 and Ang4 play important regulatory roles in the response to chronic colitis and the development of colitis-associated cancer and may serve as novel therapeutic targets.
Herpes Simplex Virus Pseudotumor Masking as Gastric Malignancy
Authors: Kripalani Simran , Williams Jennifer , Joneja Upasana , Bansal Preeti , Spitz Francis 
Published: March 2023

ABSTRACT
Herpes simplex virus (HSV) pseudotumor is a rare presentation of HSV and has not been previously reported in the stomach. A 51-year-old man with a medical history of HIV presented with new-onset dysphagia. Endoscopy revealed an HSV-positive mass at the gastroesophageal junction. After antiviral treatment, the patient returned with a 100-pound unintentional weight loss. Computed tomography showed an infiltrative mass with enlarged lymph nodes. The mass had progressed despite HSV treatment, and a repeat set of biopsies were negative for HSV with cells concerning for B-cell lymphoma. The patient was taken to the operating room for a full-thickness biopsy because of increasing concern for malignancy. The procedure was complicated by gastric perforation, leading to a total gastrectomy. Final pathology demonstrated an HSV-positive pseudotumor, negative for malignancy. It is important to diagnose gastric masses, especially in HIV-positive patients at high risk of infection and malignancy. However, immunocompromised patients with an HSV-positive mass should be treated for HSV pseudotumor with a longer than standard duration of antiviral therapy.
Self-Efficacy and the Impact of Inflammatory Bowel Disease on Patients' Daily Lives
Authors: Sheehan Jessica L. , Greene-Higgs LaVana , Swanson Linnea , Higgins Peter D.R. , Krein Sarah L. , Waljee Akbar K. , Saini Sameer D. , Berinstein Jeffrey A. , Mellinger Jessica L. , Piette John D. , Resnicow Ken , Cohen-Mekelburg Shirley 
Published: March 2023

INTRODUCTION:
Self-efficacy, i.e., the confidence in one's capacity to perform a behavior, is crucial to the development of inflammatory bowel disease (IBD) self-management skills. We aimed to measure IBD self-efficacy and the relationship between self-efficacy and the patient-reported impact of IBD on daily life.

METHODS:
We surveyed patients with IBD from a single academic center using the IBD Self-Efficacy Scale (IBD-SES) and patient-reported outcome (PRO) measures. The IBD-SES assesses 4 IBD domains: patients' confidence in managing stress and emotions, symptoms and disease, medical care, and remission. IBD PROs evaluate daily life impact, coping strategies, emotional impact, and systemic symptoms. We examined the association between IBD-SES domains with the lowest scores and IBD daily life impact.

RESULTS:
A total of 160 patients completed the survey. Domain scores on the IBD-SES were lowest for managing stress and emotions (mean 6.76, SD 1.86) and symptoms and disease (mean 6.71, SD 2.12) on a 1–10 scale. Controlling for age, sex, IBD type, disease activity, moderate-to-severe disease, depression and anxiety, a higher confidence in managing stress and emotions (β −0.12, 95% confidence interval −0.20 to −0.05, P = 0.001), and managing symptoms and disease (β −0.28, 95% confidence interval −0.35 to −0.20, P < 0.001) were each associated with lower IBD daily life impact.

DISCUSSION:
Patients with IBD report low confidence in managing stress and emotion and managing symptoms and disease. Higher self-efficacy in these domains was associated with lower IBD daily life impact. Self-management tools that promote self-efficacy in managing these domains have the potential to reduce IBD's daily life impact.
The apatinib and pemetrexed combination has antitumor and antiangiogenic effects against NSCLC
Authors: Zhou Ling , Zhang Wenchao , Xiang Yi , Qian Zijun , Zhou Jianping , Ni Lei , Feng Yun , Gao Beili 
Published: March 2023

Abstract
Chemotherapy for advanced non-small-cell lung cancer (NSCLC) remains the first treatment choice. Angiogenesis inhibitors are effective for lung cancer treatment. This study explored whether chemotherapy combined with angiogenesis inhibitors could achieve better efficacy in NSCLC. The zebrafish A549 xenograft model was used to investigate the combined effect of apatinib and chemotherapeutic agents in NSCLC. Apatinib combined with pemetrexed demonstrated the highest antitumor effect compared with apatinib combined with gemcitabine or paclitaxel in vitro. In the zebrafish A549 xenograft model, apatinib and pemetrexed, alone or in combination, showed significant inhibition of tumor growth. Co-treatment with apatinib and pemetrexed demonstrated the best antitumor effects, suggesting that the combination of apatinib and pemetrexed might be a promising alternative therapy for patients with lung cancer. Apatinib combined with pemetrexed had enhanced antitumor effects compared with either one alone in the zebrafish model of NSCLC.
Causality and independence in perfectly adapted dynamical systems
Authors: Blom Tineke , Mooij Joris M. 
Published: March 2023

AbstractPerfect adaptation in a dynamical system is the phenomenon that one or more variables have an initial transient response to a persistent change in an external stimulus but revert to their original value as the system converges to equilibrium. With the help of the causal ordering algorithm, one can construct graphical representations of dynamical systems that represent the causal relations between the variables and the conditional independences in the equilibrium distribution. We apply these tools to formulate sufficient graphical conditions for identifying perfect adaptation from a set of first-order differential equations. Furthermore, we give sufficient conditions to test for the presence of perfect adaptation in experimental equilibrium data. We apply this method to a simple model for a protein signalling pathway and test its predictions in both simulations and using real-world protein expression data. We demonstrate that perfect adaptation can lead to misleading orientation of edges in the output of causal discovery algorithms.
Experimental and numerical investigation of crashworthiness performance for optimal automobile structures using response surface methodology and oppositional based learning differential evolution algorithm
Authors: Yildirim Ahmet , Demirci Emre , Karagöz Selçuk , Özcan Şevket , Yildiz Ali Riza 
Published: March 2023

Abstract
In this study, experimental and numerical crash analyses are carried out to reach an optimum bumper beam and energy absorber design for a passenger car. Design parameters have been created to determine the most crash-efficient bumper beam and energy absorber models. The models that are formed by using Taguchi tables are subjected to crash analysis, and the responses are obtained to find an optimal design. Response surface methodology is used to approximate the structural responses in crash analysis, and the optimum bumper beam and energy absorber models are obtained by the differential evolution algorithm. The optimum model is subjected to crash analysis in the Hyperform software without considering the sheet metal forming effect. Besides, the model is analyzed by incorporating forming history into the crash analysis. As a result of the numerical analysis, a new energy absorber and bumper beam model with the better crash performance and weight reduction are obtained.
Legal Problems and Solutions in Stablecoins: A Multi-Disciplinary Approach Applied to Euro Stablecoins
Authors: Sheehy Benedict , Hawkins John , Diaz-Granados Juan 
Published: March 2023

Abstract
An increasingly important form of electronic currency is the ‘stablecoin’. Unlike other high-profile ‘cryptocurrencies’, such as Bitcoin, stablecoins claim to be matched by a corresponding amount of secure assets in a national currency to which the stablecoin can be converted at par. These crypto-assets, however, create significant legal and economic problems. Notably, issues about trust in both issuers and backing assets, the risk of runs, and particular challenges associated with public and private law regimes resist the adoption of stablecoin both in Europe and beyond. This article draws from previous experiences to analyse these issues and propose solutions. Taking a multi-disciplinary approach, the article argues that the legal and economic issues surrounding today’s stablecoins could be addressed using the lessons from prior centuries.
Migration Strategies and Human-Made Disasters: Considering Tajik Migration Policy Initiatives in Tashkorgan from the Perspective of Disaster Anthropology
Authors: Phuong Nguyen Tram Thi 
Published: March 2023

Abstract
This article examines the Pamiri Tajik population in China at the southwesternmost corner of the Xinjiang Uyghur Autonomous Prefecture and their struggles during numerous local natural and human-made disasters over the past decade. It explores, from the local point of view, the disaster recovery policies that function as a disguise for homogenization-oriented state-building initiatives. It examines how the local Tajik people have been reacting to and coping with natural disasters and the related relocation policy initiatives and how the disaster they are increasingly facing is the desecration of their homeland and the destruction of their traditional livelihood. The fieldwork findings reported are based on 12 years of fieldwork throughout Xinjiang, the Pamiri borderlands (both in the Pamiri region in Tajikistan and Tashkurgan Tajik Autonomous County in Xinjiang, China) as well as in the lowland relocation and sedentarization area in the Rabot resettlement township and the Tajik Abat resettlement township on the edge of the Taklimakan desert.
Energy Security Challenges and Opportunities for the Country of Georgia
Authors: Pignatti Norberto 
Published: March 2023

Abstract
Georgia is a small, open, developing economy, situated in a key geopolitical area at the crossroads between Europe and Asia, striving to achieve greater energy and national security. Achieving energy security, however, can be challenging for a country poorly endowed with fossil fuels and with limited interactions with broader international energy markets. Georgia, luckily, has the potential to dramatically increase its energy security in the coming decades by means of greater integration with its neighbours and European energy markets, and building on the current emphasis on (and support for) energy transition and decarbonisation initiatives to fight climate change, leveraging its endowment of renewable energy sources and its strategic location between Europe and Asia.
Tackling and Regulating Disasters. An Introduction
Authors: Tzaneva Elya 
Published: March 2023

Abstract
Today, disasters of different kinds are inseparable from the lives of individuals and of communities. They thrust themselves into people’s existence and bring chaos to organised society, as they challenge, disrupt and change the typical patterns of relations between people and their environment, both natural and social. This subject is positioned in the relatively newly established scientific field of disaster anthropology. Taken together, the articles included have made extensive use of research material to show that human communities and their cultures are formed under the influence of the natural environment, the physical and mental characteristics of the people in them and, accordingly, of the social and economic development they themselves create. The articles examine various questions and subjects and allow comparison of the existing danger of disaster and the vulnerability of the groups affected by disaster, and consider the construction of their behavioural responses in managing disaster, and their relations at official, institutional and personal levels. There is consideration too of changes in the social environment, and of the effects of disasters on the political and economic development of the countries and communities in which they occur.
A new method to improve the real-time performance of aero-engine component level model
Authors: Cai Changpeng , Zheng Qiangang , Zhang Haibo 
Published: March 2023

Abstract
In order to improve the real-time performance of aero-engine component-level models, an automatic fast positioning interpolation method is proposed. Based on the maximum parameter slope, this method can automatically determine the interpolation cut in point, change the disadvantage of low efficiency of traditional sequential interpolation from the starting point, effectively reduce the interpolation interval, thus greatly improving the efficiency of interpolation. The method is applied to the calculation of gas thermodynamic parameters and the interpolation of the characteristic of rotating parts ,so as to ameliorate the real-time performance of the single-stage flow path calculation of the component-level model. Simulation results show that, compared with the traditional method, the method proposed in this paper improves the fan characteristic calculation efficiency by 47.5%, reduces the time of single complete flow calculation by 74.3% when the dynamic and steady-state accuracy changes are less than 0.4%, which greatly improves the real-time performance of the component-level model.
Modeling of Fatigue Cracking in Asphalt Materials Based on the Paris Law with an Initialization Term—Calibration from Notched and Unnotched Specimens
Authors: Santos Ibishola , Chupin Olivier , Piau Jean-Michel , Marsac Paul , Hammoum Ferhat 
Published: March 2023

Abstract
This article aims at presenting a thermo-mechanical model dedicated to fatigue cracking in bituminous material. The model calibration based on two-point bending (2PB) fatigue tests performed on specimens of bitumen-bound sand is also detailed. In the model, crack growth is handled by the Paris law considering the initialization term Nini. This parameter represents the number of loading cycles required to initiate a short macrocrack of length a0 from which the Paris law can be applied. The tests utilized for calibration and comparison with the numerical simulations are performed on notched and unnotched trapezoidal samples, for different levels of imposed displacement amplitude. The parameters of the Paris law are determined using the notched specimens (a0 being assimilated to the notch depth) except for Nini, which is deduced from the difference in lifetime duration between the tests carried out on notched and unnotched specimens. The full calibration procedure described thereafter has the advantage to not depend on the choice of a0. It is shown that the simulations run for the calibrated model are globally in good agreement with the test results obtained for both types of samples and for all the imposed displacement amplitudes. Finally, the model is used to predict the response of four-point bending tests carried out on the same bitumen-bound sand, considering the input parameters determined from the 2PB tests. The intrinsic nature of the model is evaluated through its ability to simulate both types of tests using the same set of material parameters.