bluuebunny/crossref_metadata_2025_split huggingface dataset:
McCune-Albright Syndrome: A-rare-case report
Authors: Yunita Ivana , Dewi Artati Ratna , Satriono Kwari Januar , Angriani Hadia 
Published: January 2023

McCune-Albright syndrome (MAS) is a rare genetic disordered originally recognized by the triad of polyostotic fibrous dysplasia, precocious puberty, and cafe-au-late spots. We report a case of 2 years-11-month-old girl who came with complaints of menstruation 5 days ago. Breasts appear enlarged. On physical examination, it appears that the café au lait region of the abdomen and left femur resembles the "coast of Maine". There was an increase in the levels of FT4, estradiol, and alkaline phosphatase, and low TSHs, LH, and FSH levels. The radiological examination of the bones of the left hand corresponded to the bone age of 6 years. Bone survey photo showing multiple lytic and blastic lesions in the proximal 1/3 of the left femur. We are monitoring this patient, and planning to administer Tamoxifen and Zoledronic acid. Tamoxifen (an estrogen agonist/antagonist) or Letrozole (an aromatase inhibitor) have been used for the management of precocious puberty and rapid bone maturation. Despite differing in presentation, all patients with precocious puberty were successfully treated with Tamoxifen and/or Letrozole, to emphasize the significant progress of bone age. A systematic approach to diagnosis and management is essential to optimize outcomes for patients with MAS, especially with fibrous dysplasia. No medical therapy is able to change the course of the disease in fibrous dysplasia. However, screening and treatment for endocrinopathy can reduce some bone morbidities.
Pengaruh Komunikasi, Pengawasan Terhadap Kinerja Guru Dan Karyawan Smp Negeri 2 Jatilawang Banyumas
Authors: Suseno Suseno , Yusat Krishna Santoso 
Published: January 2023

Judul penelitian Pengaruh Komunikasi, Pengawasan Terhadap Kinerja Guru Dan Karyawan SMP Negeri 2 Jatilawang Banyumas , Tujuan a)menganalisis pengaruh komunikasi dan pengawasan secara bersama-sama terhadap kinerja guru dan karyawan SMP Negeri 2 Jatilawang. b) menganalisis pengaruh komunikasi dan pengawasan secara parsial terhadap kinerja guru dan karyawan SMP Negeri 2 Jatilawang Hipotesis: 1)Komunikasi dan pengawasan secara bersama-sama berpengaruh terhadap kinerja guru dan karyawan SMP Negeri 2 Jatilawang. 2)Komunikasi dan pengawasan secara parsial berpengaruh terhadap kinerja guru dan karyawan SMP Negeri 2 Jatilawang.Sampel 48, metode uji Multikolinieritas; Linieritas, Uji F, Uji t. Kesimpulan: 1) Komunikasi dan pengawasan secara bersama-sama berpengaruh terhadap kinerja guru dan karyawan. Fhitung Ftabel (33,007 4,052), hipotesis pertama komunikasi dan pengawasan bersama-sama berpengaruh terhadap kinerja guru dan karyawan SMP Negeri 2 Jatilawang, diterima. 2) Nilai thitung kedua variabel bebas (tX1(3,907);tX2(4,221) 2,032), hipotesis kedua komunikasi dan pengawasan secara parsial berpengaruh terhadap kinerja guru dan karyawan SMP Negeri 2 Jatilawang, diterima. Implikasi: 1)meningkatkan kinerja, komunikasi, pengawasan tugas dan kewajiban guru dan karyawan. 2)menjaga kesinambungan kinerja, komunikasi, pengawasan kinerja
PKM Sosialisasi Pengelolaan Sampah dengan Alat Pintar Mikrokontroler Sistem IOT dan Kontrol Telegram di SMK Zainul Hasan Genggong
Authors: Hudawi Ahmad , As'adi Muhammad , Thaariq Muhammad Haikal Ath , Amir Muhammad , Ridho Muhammad Ali 
Published: January 2023

Meningkatnya kebutuhan masyarakat terhadap berbagai macam produk, serta meningkatnya UMKM yang mendukung pertumbuhan ekonomi daerah pasti menyebabkan meningkatnya jumlah sampah yang drastis, dengan meningkatnya jumlah sampah yang dihasilkan, pengelolaan sampah yang kurang baik berdampak pada permasalahan lingkungan. Sampah adalah sebuah ancaman bagi lingkungan sekitar kita, akibat pembuangan sampah sembarangan tempat, disamping merusak lingkungan juga merusak ekosistem lingkungan, dan menyebabkan pencemaran terhadap air, sampah-sampah plastik yang tidak bisa diuraikan oleh tanah akan mengakibatkan menumpuknya sampah dan limbah, kesadaran akan bahaya membuang sampah sembarangan sangat kurang. Dalam permasalahan tersebut maka perlu adanya tempat sampah pintar berbasis Mikrokontroler Arduino yang meliputi Sensor Ultrasonic HC-SR04 sebagai pendeteksi jarak dan pendeteksi volume tempat sampah, Penggunaan sensor otomatis dengan remot kontrol yang bertujuan memberikan pemahaman peran alat pintar ini adalah solusi yang maksimal rancang bangun tempat sampah secara otomatis menggunakan sensor ultrasonik adalah sensor ultrasonik mendeteksi seseorang di depan tempat sampah kurang dari 70 cm, selanjutnya yaitu data diproses oleh arduino uno untuk memutar motor servo dalam membuka tutup tempat sampah. Hasill bahwa sosialisasi memberikan pengaruh terhadap nilai pre test dan post test. Hal ini dibuktikan dengan nilai Sig. < 0,05 yaitu sebesar 0,000. Dapat disimpulkan sosialisasi tentang pengolahan sampah dengan alat pintar dapat merubah perilaku siswa SMK Zainul Hasan Genggong terhadap kesadaran kebersihan lingkungan
Suture tape augmentation, a novel application of synthetic materials in anterior cruciate ligament reconstruction: A systematic review
Authors: Zheng Tong , Cao Yanwei , Song Guanyang , Li Yue , Zhang Zhijun , Feng Zheng , Zhang Hui 
Published: January 2023

Objective: Suture tape (ST) is a common synthetic material in the repairing surgery of soft tissue. Recently, ST augmentation (STA) technique has been described as a novel way to improve the mechanical property of grafts in the anterior cruciate ligament (ACL) reconstruction (ACLR). However, the clinical outcomes of ACLR using ST-augmented grafts have not been clarified. This systematic review aimed to summarize the specific technique of STA and evaluate the clinical outcomes after ACLR with STA.Methods: A electronic search of PubMed and Embase databases with a manual search of Google Scholar was performed to identify studies that reported the clinical outcomes of ACLR with STA. Each included study was abstracted regarding the study features, patient data, surgical information, and outcome measures.Results: Nine studies were included, representing 314 knees in 314 patients undergoing ACLR with STA. Technically, ST was fixed independently from grafts in six studies and along with grafts in two studies. Most studies applied an equal or slightly less tension on ST than ACL graft. Clinically, significant improvements were found in the Lysholm, IKDC, and KOOS scores after a mean follow-up of 16.7 months. Physical examinations of 220 patients showed significant restoration of knee stability at the final follow-up. 59 of 80 (73.8%) patients returned to preinjury sports level at a minimum 2 year follow-up. Six of 266 (2.3%) patients had a graft failure during the first 2 years postoperatively. The use of ST was significantly associated with better Tegner scores and a trend toward significantly higher rates of return to sport compared to standard ACLR. No significant difference was found in most subjective scores, knee laxity, and graft failures between ACLR with or without STA.Conclusion: ACLR with STA achieved overall favorable clinical outcomes. Patients using ST-augmented grafts were seemingly associated with better sports performance compared to standard ACLR. But ACLR with STA was not superior to ACLR alone in most functional scores, knee stability measures, and graft failure rates. A tension equal to or slightly less than the ACL graft should be carefully applied on ST during fixation to avoid stress shielding of the graft.
Effect of retrograde condensation and stress sensitivity on properties of condensate gas reservoirs
Authors: Li Nan , Li Haosen , Tan Xianhong , Zhang Lijun , Liu Yuwei 
Published: January 2023

In the production process of low permeability condensate gas reservoir, the reverse condensate action and stress sensitivity will lead to the decrease of reservoir permeability and gas well productivity. However, there are few studies on the effect of retrograde condensation and stress sensitivity on permeability. In this study, the stress-sensitive experiments using the method with constant confining pressure but variable inner pressure were carried out on three cores from the BZ gas field in southwestern Bohai Sea. The test result that use the nitrogen as the experimental fluid represent the effect of core skeleton damage on reservoir permeability during formation pressure drop, and the test result that use the condensate gas as the experimental fluid represent the effect of core skeleton damage and retrograde condensation on reservoir permeability. The results reveal that when the formation pressure drops to the dew point pressure, retrograde condensation damage is the main cause of permeability decline. And the effects of core skeleton damage will increase as the formation pressure drops and exceed the retrograde condensation damage when the net stress is greater 7 MPa. When the net stress reaches 20 MPa, the core skeleton damage accounts for more than 90% of the total damage. Furthermore, the gas well production was calculated considering stress sensitivity and retrograde condensation based on the experimental results, the result shows that gas well production decreases by 97.65% when retrograde condensation is considered. This study can provide a reference for quantitative evaluation of the retrograde condensation and stress sensitivity in the production process of condensate gas reservoir.
Better oral hygiene is associated with a reduced risk of cataract: A nationwide cohort study
Authors: Park Jung-Hyun , Lee Heajung , Kim Jin-Woo , Song Tae-Jin 
Published: January 2023

ObjectiveTo investigate the association of oral health status and oral hygiene behaviors with cataract occurrence longitudinally.Materials and methodsBased on the National Health Screening cohort database of Korea, participants who underwent oral health screening by dentists in 2003 were included. Cataract was defined as two or more claims of disease classification for the International Classification of Diseases-10 (E10.34, E11.34, E12.34, E13.34, E14.34, H25, and H26) with cataract specific treatment or surgery procedure claim codes. The occurrence of cataract was analyzed with Cox proportional hazard model according to the presence of periodontitis and oral health examination findings, including missing teeth, caries, tooth brushing, and dental scaling.ResultsOverall, 103,619 subjects were included. During a median follow-up of 12.2 years, cataract developed in 12,114 (11.7%) participants. Poor oral health status such as the presence of periodontitis (adjusted hazard ratio [HR] 1.08, 95% CI [confidence interval] 0.99–1.17, p = 0.088) and increased number of missing teeth (adjusted HR = 1.74, 95% CI = 1.55–1.96, p &lt; 0.001) was associated with the increased cataract risk. Better oral hygiene behaviors such as increased frequency of tooth brushing (adjusted HR = 0.84, 95% CI = 0.79–0.88, p &lt; 0.001) and performed dental scaling within 1 year (adjusted HR = 0.90, 95% CI = 0.86–0.94, p &lt; 0.001) were negatively associated with cataract occurrence.ConclusionPeriodontitis and increased number of missing teeth may increase the risk of cataract. However, maintaining good oral hygiene through tooth brushing and dental scaling may reduce the risk of future cataract occurrence. Further studies should be performed to confirm the association between chronic oral inflammation and cataract.
The prevalence of and risk factors for restless legs syndrome: A nationwide study
Authors: AlShareef Saad Mohammed 
Published: January 2023

ObjectivesRestless legs syndrome (RLS) is a neglected diagnosis, and most individuals with RLS do not access effective therapies. There has yet to be a nationwide study of the prevalence of and associated risk factors for RLS in Saudi Arabia.Materials and methodsA population-wide survey was administered to Saudi Arabian adults to assess RLS prevalence and its association with other clinical and demographic variables. RLS was defined according to 2012 IRLSSG Diagnostic Criteria. Persistent RLS was defined as symptoms occurring more than a few nights each week, and RLS causing significant daytime impairment was defined as symptoms causing “severe” excessive daytime sleepiness measured by the Epworth Sleepiness Scale. Associations were evaluated using univariate analyses and binary logistic regression.Results10,106 individuals completed the survey. Persistent RLS was reported in 11.9% of participants, which caused significant daytime impairment in 1.2% of participants. In multivariable analysis, younger age (OR 0.96, 95% CI 0.95–0.97; p &lt; 0.001), tobacco smoking (OR 1.28, 95% CI 1.07–1.53; p = 0.008), anxiety (OR 1.34–1.42; p &lt; 0.05), and moderate to severe depressive symptoms (OR 1.52–2.40; p &lt; 0.01) were associated with persistent RLS. Younger age (OR 0.96, 95% CI 0.93–0.99; p = 0.015), female gender (OR 2.28, 95% CI 1.32–3.94; p = 0.003), and moderately severe to severe depressive symptoms (OR 13.59 and 26.7, respectively; p &lt; 0.001) were independently associated with RLS causing significant daytime impairment.ConclusionRLS is common in adults in Saudi Arabia and is often co-morbid with moderate to severe depressive symptoms. Both RLS and depression represent a silent epidemic in Saudi Arabia requiring active inquiry by all healthcare workers to reduce their burden and impact.
Leiomyoma of the prostate: A case report and systematic review
Authors: Wang Shangren , Huang Shiqiao , Pan Yang , Ma Yong , Kang Jiaqi , Liu Li , Liu Xiaoqiang 
Published: January 2023

PurposeIt is rare to find a large leiomyoma in the prostate, especially in that of a young man. This case report and systematic review provides additional information on the diagnosis, distinguishing features of imaging examinations, and treatment options.Patients and MethodsWe report on the case of a thirty-year-old man with a large leiomyoma of the prostate. MRI of the prostate revealed a round mass in the posterior lobe, 8.0 × 8.0 × 5.5 cm in size. With the assistance of laparoscopy, we resected the prostate mass completely and spared this organ. A systematic review was conducted utilizing the Preferred Reporting Items for Systematic Reviews (PRISMA) including English language published reports, from 1970 to December 2021.ResultsUrinary and erectile functioning was preserved postoperatively. After a year of follow-up, no evidence of recurrence emerged. A total of 21 studies were included for analysis.ConclusionsA medical history of no, or few, lower urinary tract symptoms; the characteristics of a benign tumor in imaging examinations; and negative tumor markers should be included in any differential diagnosis of leiomyoma of the prostrate. A prostate biopsy should be performed before the preparative radical prostatectomy and choose nonsurgical treatment to confirm the diagnosis. Nowadays, minimally invasive surgery is the preferred effective option for this disease. It is a rare recurrence after its removal by means of surgery.
3D-QSAR Studies, Molecular Docking, Molecular Dynamic Simulation, and ADMET Proprieties of Novel Pteridinone Derivatives as PLK1 Inhibitors for the Treatment of Prostate Cancer
Authors: Er-rajy Mohammed , El fadili Mohamed , Imtara Hamada , Saeed Aamir , Ur Rehman Abid , Zarougui Sara , Abdullah Shaef A. , Alahdab Ahmad , Parvez Mohammad Khalid , Elhallaoui Menana 
Published: January 2023

Overexpression of polo-like kinase 1 (PLK1) has been found in many different types of cancers. With its essential role in cell proliferation, PLK1 has been determined to be a broad-spectrum anti-cancer target. In this study, 3D-QSAR, molecular docking, and molecular dynamics (MD) simulations were applied on a series of novel pteridinone derivatives as PLK1 inhibitors to discover anti-cancer drug candidates. In this work, three models—CoMFA (Q² = 0.67, R² = 0.992), CoMSIA/SHE (Q² = 0.69, R² = 0.974), and CoMSIA/SEAH (Q² = 0.66, R² = 0.975)—of pteridinone derivatives were established. The three models that were established gave Rpred2 = 0.683, Rpred 2= 0.758, and Rpred 2= 0.767, respectively. Thus, the predictive abilities of the three proposed models were successfully evaluated. The relations between the different champs and activities were well-demonstrated by the contour chart of the CoMFA and CoMSIA/SEAH models. The results of molecular docking indicated that residues R136, R57, Y133, L69, L82, and Y139 were the active sites of the PLK1 protein (PDB code: 2RKU), in which the more active ligands can inhibit the enzyme of PLK1. The results of the molecular dynamic MD simulation diagram were obtained to reinforce the previous molecular docking results, which showed that both inhibitors remained stable in the active sites of the PLK1 protein (PDB code: 2RKU) for 50 ns. Finally, a check of the ADME-Tox properties of the two most active molecules showed that molecular N° 28 could represent a good drug candidate for the therapy of prostate cancer diseases.
Mapping between Spin-Glass Three-Dimensional (3D) Ising Model and Boolean Satisfiability Problem
Authors: Zhang Zhidong 
Published: January 2023

The common feature for a nontrivial hard problem is the existence of nontrivial topological structures, non-planarity graphs, nonlocalities, or long-range spin entanglements in a model system with randomness. For instance, the Boolean satisfiability (K-SAT) problems for K ≥ 3 MSATK≥3 are nontrivial, due to the existence of non-planarity graphs, nonlocalities, and the randomness. In this work, the relation between a spin-glass three-dimensional (3D) Ising model MSGI3D with the lattice size N = mnl and the K-SAT problems is investigated in detail. With the Clifford algebra representation, it is easy to reveal the existence of the long-range entanglements between Ising spins in the spin-glass 3D Ising lattice. The internal factors in the transfer matrices of the spin-glass 3D Ising model lead to the nontrivial topological structures and the nonlocalities. At first, we prove that the absolute minimum core (AMC) model MAMC3D exists in the spin-glass 3D Ising model, which is defined as a spin-glass 2D Ising model interacting with its nearest neighboring plane. Any algorithms, which use any approximations and/or break the long-range spin entanglements of the AMC model, cannot result in the exact solution of the spin-glass 3D Ising model. Second, we prove that the dual transformation between the spin-glass 3D Ising model and the spin-glass 3D Z2 lattice gauge model shows that it can be mapped to a K-SAT problem for K ≥ 4 also in the consideration of random interactions and frustrations. Third, we prove that the AMC model is equivalent to the K-SAT problem for K = 3. Because the lower bound of the computational complexity of the spin-glass 3D Ising model CLMSGI3D is the computational complexity by brute force search of the AMC model CUMAMC3D, the lower bound of the computational complexity of the K-SAT problem for K ≥ 4 CLMSATK≥4 is the computational complexity by brute force search of the K-SAT problem for K = 3 CUMSATK=3. Namely, CLMSATK≥4=CLMSGI3D≥CUMAMC3D=CUMSATK=3. All of them are in subexponential and superpolynomial. Therefore, the computational complexity of the K-SAT problem for K ≥ 4 cannot be reduced to that of the K-SAT problem for K < 3.
INTELIGENCIA EMOCIONAL Y RENDIMIENTO ACADÉMICO EN ESTUDIANTES UNIVERSITARIOS. ESTADO ACTUAL DEL CONOCIMIENTO
Authors: Pérez Jaimes Alejandra Karina , Torres Zapata Ángel Esteban , Lara Gamboa Carmen Cecilia , Estrada Reyes César Uziel , Brito Cruz Teresa del Jesús , Sánchez May María del Carmen 
Published: January 2023

En el campo de la investigación orientada al estudio de la Inteligencia Emocional, existe actualmente una connotación enfatizada en la línea de investigación que se direcciona al análisis del papel que juegan las emociones en relación al desarrollo óptimo de los sujetos en el contexto educativo en relación al éxito académico y al nivel de adaptación escolar que presentan los estudiantes. La presente investigación tiene como objetivo caracterizar el nivel de conocimiento actual que se posee sobre la inteligencia emocional y la interrelación con el rendimiento académico. Se presenta un estudio documental descriptivo, revisión de artículos científicos, utilizando enunciados claves “inteligencia emocional” y “rendimiento académico” en el buscador Google Académico. Los artículos se analizaron mediante una matriz de doble entrada identificando la correspondencia entre objetivos, metodología, resultados y conclusiones. Se determinaron 96,500 resultados en 0.20 segundos, de los cuales, el 0.0083 % cumplen con los criterios de inclusión. Actualmente es imperativa la necesidad de reconocer y considerar que los aspectos emocionales tienen grandes implicaciones educativas, sobre todo en lo relacionado al bienestar emocional, la mejora de la convivencia escolar y el rendimiento de los estudiantes. Por lo cual las instituciones de educación superior cada vez más se suman a la incorporación de dicha perspectiva reconociendo que la adquisición de conocimientos meramente académicos no es suficiente para conseguir el éxito escolar.
Health Education With Hypertension Treatment Video Media Increases Knowledge About Hypertension Treatment
Authors: Widiati Amrih , Rahmawati Puput 
Published: January 2023

Hypertension is high blood pressure in the arteries causing an increased risk of cardiovascular diseases such as stroke, kidney failure, heart attack, and kidney damage. Hypertension treatment begins with increasing public knowledge about hypertension treatment management. Objective: Knowing the effectiveness of health education through the media of posters and videos on client knowledge about hypertension treatment. The method uses a quantitative approach with a quasi-experiment two-group pre-posttest. The total sample of 20 respondents was obtained with purposive sampling techniques. The statistical test uses a paired t-test test and different test-independent t-tests. The results showed the average value of respondents' knowledge before being given health education through posters of 14.75 and after 17.90. The average score of respondents' knowledge before being given health education through video was 15.15 and after was 22.50. There is an effect of health education through posters and videos on client knowledge about hypertension treatment, a p-value of 0.000 (<0.05) is obtained. Conclusion: Health education through video media is considered more effective against changes in client knowledge about hypertension treatment. Keywords: health education; hypertension; knowledgePendidikan Kesehatan Dengan Media Video Perawatan Hipertensi Meningkatkan Pengetahuan Tentang Perawatan HipertensiABSTRAK Hipertensi adalah tekanan darah tinggi di arteri menyebabkan peningkatan risiko penyakit kardiovaskular seperti stroke, gagal ginjal, serangan jantung, dan kerusakan ginjal. Pengobatan hipertensi diawali dengan peningkatan pengetahuan masyarakat tentang penatalaksanaan pengobatan hipertensi. Tujuan: Mengetahui efektifitas penyuluhan kesehatan melalui media poster dan video terhadap pengetahuan klien tentang pengobatan hipertensi. Metode yang digunakan adalah pendekatan kuantitatif dengan quasi eksperimen two group pre-posttest. Jumlah sampel sebanyak 20 responden diperoleh dengan teknik purposive sampling. Uji statistik menggunakan uji t-test berpasangan uji beda independent t-test. Hasil penelitian menunjukkan rata-rata nilai pengetahuan responden sebelum diberikan penyuluhan kesehatan melalui poster sebesar 14,75 dan sesudah diberikan 17,90. Rata-rata skor pengetahuan responden sebelum diberikan penyuluhan kesehatan melalui video adalah 15,15 dan sesudahnya adalah 22,50. Terdapat efektifitas penyuluhan kesehatan melalui poster dan video terhadap pengetahuan klien tentang pengobatan hipertensi didapatkan nilai p 0,000 (<0,05). Kesimpulan: Pendidikan kesehatan melalui media video dinilai lebih efektif terhadap perubahan pengetahuan klien tentang pengobatan hipertensi.Kata kunci: pendidikan kesehatan; hipertensi; pengetahuan