bluuebunny/crossref_metadata_2025_split huggingface dataset:
A novel combined C‐reactive protein‐albumin ratio and modified albumin‐bilirubin score can predict long‐term outcomes in patients with hepatocellular carcinoma after hepatic resection
Authors: Aida Takashi , Haruki Koichiro , Akaoka Munetoshi , Furukawa Kenei , Onda Shinji , Shirai Yoshihiro , Shiozaki Hironori , Takahashi Keita , Oikawa Tsunekazu , Ikegami Toru 
Published: August 2023

AbstractBackgroundSystemic inflammatory response represented by C‐reactive protein and albumin ratio (CAR) and modified albumin‐bilirubin (mALBI) grade both have been associated with long‐term outcome in patients with hepatocellular carcinoma (HCC). In this study, we investigated the prognostic utility of combined score of CAR and mALBI score to predict the prognosis of HCC patients after hepatic resection.MethodsThis study included 214 patients who had undergone primary hepatic resection for HCC between 2008 and 2018. Systemic inflammatory response and mALBI were evaluated preoperatively and patients were classified into three groups based on the combination of CAR and mALBI score: low CAR and low mALBI grade (score 0), either high CAR or high mALBI grade (score 1), and both high CAR and high mALBI grade ≥2b (score 2). Multivariate Cox proportional hazard models were conducted to assess disease‐free and overall survival.ResultsIn multivariate analysis, sex (p < 0.01), HBsAg positivity (p < 0.01), serum AFP level ≥20 ng/mL (p < 0.01), microvascular invasion (p = 0.02), multiple tumors (p < 0.01), type of resection (p < 0.01), and CAR‐mALBI score ≥2 (HR 2.19, 95% CI 1.39–3.44, p < 0.01) were independent prognostic factors of disease‐free survival, while sex (p = 0.01), HBsAg positivity (p < 0.01), poor tumor differentiation (p = 0.03), multiple tumors (p < 0.01), CAR‐mALBI score ≥2 (HR 2.70, 95% CI 1.51–4.83, p < 0.01) were independent prognostic factors of overall survival.ConclusionsCAR‐mALBI score is associated with disease‐free and overall survival in patients with HCC after hepatic resection, suggesting the importance of evaluating both hepatic functional reserve and host‐inflammatory state in the risk assessment of HCC patients.
Ionic liquid‐induced deep grafting of polyelectrolyte to reform polyamide layer for antifouling nanofiltration membrane
Authors: Liu Lulu , Liu Yuxuan , Wan Yinhua , Song Weijie , Lu Hongwei , Luo Jianquan 
Published: August 2023

AbstractSurface grafting has been widely used to tune hydrophilicity and chargeability of nanofiltration membranes for reducing membrane fouling potential. However, surface grafting typically leads to a significant pore narrowing and resultant permeability loss, and monocharged surface still struggles to resist mixed foulants with different charges. Herein, ionic liquid (IL)‐ethanol (EtOH) solution containing polyethyleneimine (PEI) is used to rearrange the nascent polyamide layer. The high affinity of IL to the PA layer and the low diffusion steric hindrance of EtOH contribute to the polyamide swelling and PEI deep grafting, during which the “self‐regulation” effect (larger pores would be filled with more PEI molecules) narrows the pore size distribution and enhances hydrophilicity. The nearly charge‐neutral and smooth separation layer shows impressive antifouling capacity to hydrophobic macromolecules and mixed charged molecules, along with long‐term operating stability for real wastewater treatment. This study emphasizes the importance of solvent properties on the membrane grafting behavior.
Interpolation of probability‐driven model to predict hydrodynamic forces and torques in particle‐laden flows
Authors: Zhu Li‐Tao , Wachs Anthony 
Published: August 2023

AbstractThe development of hydrodynamic force/torque closure models with physical fidelity is crucial for ensuring reliable Euler–Lagrange simulations in particle‐laden flows. Our previous work (Seyed‐Ahmadi and Wachs. J Fluid Mech. 2020;900:A21) proposed a microstructure‐informed probability‐driven point‐particle (MPP) method to construct a data‐driven particle‐position‐dependent closure model, incorporating the effect of surrounding particle positions on forces/torques. However, the MPP model is not pluggable in Euler–Lagrange simulations due to the computation of constant coefficients through linear regression and reliance on statistical arguments to obtain the probability map for a pair of values of solid volume fraction (Φ) and Reynolds number (Re). To overcome this limitation, we propose an interpolated MPP (iMPP) method, involving interpolation in the Φ and Re spaces. Our results demonstrate that the iMPP method can capture over 70% of the total fluctuations in hydrodynamic forces/torques in approximately 97.8% of the tested cases. This advancement contributes to a more versatile closure model suitable for integration into E‐L simulations.
Social isolation and loneliness in family caregivers of people with severe mental illness: A scoping review
Authors: Guan Ziyao , Poon Abner Weng Cheong , Zwi Anthony 
Published: August 2023

AbstractFamily caregivers of people with severe mental illness (SMI) have been increasingly observed to experience social isolation and/or loneliness (SI/L) which are risk factors for ill health. This scoping review aimed to map existing evidence and identify knowledge gaps in studies on SI/L in this population using the Arksey and O'Malley's framework. Parallel searches (2011–2021) conducted in 10 databases identified 51 publications from 18 countries fully meeting the inclusion criteria. Over half of the included studies were quantitative. We found that the definition of loneliness reached a consensus, while the definition of social isolation varied across studies. Risk factors and correlates of SI/L were grouped into sociodemographic factors, illness‐related factors, health and wellbeing, and stigma. The evidence showed a lack of comprehensive measurements assessing SI/L, few longitudinal studies, and little knowledge of interventions specifically addressing SI/L. Future studies are recommended to address these knowledge gaps and explore effective interventions on SI/L in family caregivers of people with SMI.
Skeletal muscle mass in competitive physique‐based athletes (bodybuilding, 212 bodybuilding, bikini, and physique divisions): A case series
Authors: Moreno Enrique N. , Hammert William B. , Montgomery Tony R. , Abe Takashi , Loenneke Jeremy P. , Buckner Samuel L. 
Published: August 2023

AbstractObjectives(1) To examine the muscle thickness of various muscle groups of the body to estimate the absolute and relative skeletal muscle mass (SM) in competitive physique‐based athletes (Bodybuilding, 212 Bodybuilding, Bikini, and Physique divisions) and (2) to compare values across various divisions of competition and to resistance trained and non‐resistance trained individuals.MethodsEight competitive physique‐based athletes (2 M and 6 F), two recreationally resistance trained (1 M and 1 F) and two non‐resistance trained (1 M and 1 F) participants had muscle thickness measured by ultrasound at nine sites on the anterior and posterior aspects of the body. SM was estimated from an ultrasound‐derived prediction equation and SM index was used to adjust for the influence of standing height (i.e., divided by height squared).ResultsSM values ranged from 19.6 to 60.4 kg in the eight competitive physique‐based athletes and 16.1 to 32.6 kg in the four recreationally resistance trained and non‐resistance trained participants. SM index ranged from 7.2 to 17.9 kg/m2 in the eight competitive physique‐based athletes and 5.8 to 9.3 kg/m2 in the four recreationally resistance trained and non‐resistance trained participants.ConclusionOverall, varying magnitudes of SM and SM index were present across competitors and their respective divisions of bodybuilding. The Men's Open Bodybuilder in the present study had greater values of total SM and SM index compared to previously published values in the literature. Our data provides insight into the extent of SM present in this population and further extends the discussion regarding SM accumulation in humans.
The association between the incidence of postmenopausal breast cancer and occupational exposure to selected organic solvents, Montreal, Canada, 2008–2011
Authors: Westra Sydney , Goldberg Mark S. , Labrèche France , Baumgartner Jill , Ho Vikki 
Published: August 2023

AbstractBackgroundBreast cancer is the most diagnosed cancer among women and recognized risk factors explain 25%–47% of cases. Organic solvents are used widely in the workplace and exposure may increase the risk of developing breast cancer, yet there are insufficient data to confirm this hypothesis. We sought to determine whether past occupational exposures to selected organic solvents were associated with the incidence of invasive breast cancer in postmenopausal women in Montréal, Canada.MethodsFrom a population‐based case–control study (2008–2011), using in‐depth interviews we elicited information on risk factors and lifetime occupational histories. Industrial hygienists and chemists translated job descriptions into specific chemical and physical exposures. We assessed 11 individual solvents and four solvent groups. Unconditional logistic regression was used to estimate adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for metrics of past exposures to selected solvents. Exposure metrics included any previous exposure, average frequency in hours per week, duration in years, and average cumulative concentration weighted by hours per workweek exposed.ResultsWe enrolled 695 cases and 608 controls. We found increased ORs for average cumulative concentration of exposure to mononuclear aromatic hydrocarbons (OR: 1.52, 95% CI: 1.04, 2.28), chlorinated alkanes (OR: 2.42, 95% CI: 1.23, 5.68), toluene (OR: 1.59, 95% CI: 1.02, 2.59), and a group of organic solvents with reactive metabolites (OR: 1.53, 95% CI: 1.08, 2.24). Positive associations were found across all exposure metrics and were higher among women with estrogen‐positive/progesterone‐negative tumors.ConclusionOur findings suggest occupational exposure to certain organic solvents may increase the risk of incident postmenopausal breast cancer.
Copper Oxide Decorated Carbon Nanofiber Skeleton for Dendrite‐Free Lithium‐Metal Anodes
Authors: Shao Shikun , Liu Hong , Wang Chao , Li Dabing , Zhao Xiaoxue , Fan Li‐Zhen 
Published: August 2023

AbstractLithium metal, possessing a high theoretical capacity, holds great promise as a desirable anode candidate for the next‐generation high energy density lithium batteries. However, the practical implementation of lithium metal faces significant challenges, including dendrite growth and volume expansion. Herein, a carbon nanofiber (CNF) three‐dimensional (3D) current collector was developed, complemented by the addition of copper oxide nanoparticles to the CNF framework, resulting in the creation of a lithiophilic 3D current collector known as CuO‐CNF. Subsequently, a 3D lithium metal composite anode (CuO‐CNF−Li) was fabricated through an electrochemical plating process. The utilization of a 3D structure based on carbon nanofibers provides sufficient space and a stable framework for lithium ion plating, effectively accommodating the substantial volume changes that occur during repetitive Li plating and stripping. The copper oxide nanoparticles loaded onto the CNF serve as active sites for lithium nucleation, facilitating an ordered and uniform plating/stripping process of lithium ions, thereby preventing dendrite formation. Consequently, the CuO‐CNF current collector enables dendrite‐free Li plating/stripping with an average Coulomb efficiency of up to 99 % and a low nucleation overpotential of only 15 mV. Moreover, symmetric cell tests demonstrated an extended lifespan of 2700 h at 2 mA cm−2 for the CuO‐CNF−Li composite anode.
SDS‐capped 1‐pyrenecarboxaldehyde nanoprobe for selective detection of Cu2+ ion from water samples: Spectroscopic approach
Authors: Kamble Avinash A. , Dalavi Dattatray K. , Desai Netaji K. , Mahajan Prasad G. , Kolekar Govind B. , Patil Shivajirao R. 
Published: August 2023

AbstractSodium dodecyl sulfate (SDS)‐capped 1‐pyrenecarboxaldehyde nanoparticles (PyalNPs) were prepared using a reprecipitation method in an aqueous medium and exhibited red‐shifted aggregation‐induced enhanced emission (AIEE). The dynamic light scattering (DLS) examination showed narrower particle size distribution with an average particle size of 41 nm, whereas −34.5 mV zeta potential value indicate the negative surface charge and good stability of nanoparticles (NPs) in an aqueous medium. The AIEE was seen at λmax = 473 nm in a fluorescence spectrum of a PyalNP suspension. In the presence of Cu2+ ions, the fluorescence of PyalNPs quenches very significantly, even in the presence of other metal ions like Ba2+, Ca2+, Cd2+, Co2+, Al3+, Fe2+, Hg2+, Ni2+ and Mg2+. The changes in the fluorescence lifetime of PyalNPs in the presence of Cu2+ ions suggested that the type of quenching was dynamic. The fluorescence quenching data for the NPs suspension fitted well into a typical Stern–Volmer relationship in the concentration range 1.0–25 μg/ml of Cu2+ ions. The estimated value of the correlation coefficient R2 = 0.9877 was close to 1 and showed the linear relationship between quenching data and Cu2+ ion concentration. The limit of detection (LOD) was found to be 0.94 ng/ml and is far below the tolerable intake limit value of 1.3 μg/ml accepted by the World Health Organization for Cu2+ ions in drinking water. The fluorescence quenching approach for a SDS‐capped Pyal nanosuspension for copper ion quantification is of high specificity and coexisting ions were found to interfere very negligibly. The developed method was successfully applied for the estimation of copper ions in river water samples.
The significance of countable and treatable metastatic liver disease in patients with gallbladder carcinoma after curative‐intent surgery: A 10‐year experience in China
Authors: Lv Tian‐Run , Liu Fei , Ma Wen‐Jie , Hu Hai‐Jie , Jin Yan‐Wen , Li Fu‐Yu 
Published: August 2023

AbstractObjectiveOur study was performed to evaluate the significance of countable and treatable metastatic liver disease (CTMLD) in patients with gallbladder carcinoma (GBC) after curative‐intent surgery.MethodsResected GBC patients between September 2010 and January 2021 were reviewed. Comparative analyses between patients with CTMLD and those without it were performed. A propensity score matching analysis was conducted for further validation.ResultsA total of 326 resected GBC patients were identified (33 with CTMLD). A significantly higher preoperative CA199 level was detected in those with CTMLD (p = 0.0160). Significantly higher incidences of major hepatectomy (p = 0.0010), lymph node metastasis (p < 0.0001), direct liver invasion (p < 0.0001), moderate to poor differentiation status (p < 0.0001), and T3–4 disease (p < 0.0001) were detected in patients with CTMLD. Even sharing comparable surgical margin status, patients with CTMLD still shared a significantly higher recurrence rate (93.9% vs. 57.3%, p < 0.0001) as well as a significantly higher recurrence rate within 6 months after surgery (63.6% vs. 14.7%, p < 0.0001). A significantly worse overall survival (median survival time: 12 vs. 33 months, p < 0.0001) or disease‐free survival (median recurrence‐free time: 6 vs. 30 months, p < 0.0001) was acquired in patients with CTMLD. After matching, a significantly higher early recurrence rate was still detected. Adjuvant chemotherapy seemed to have survival benefit for patients with CTMLD.ConclusionCTMLD was an indicator of advanced disease and served as an independent predictor of early recurrence among resected GBC patients. Whether curative‐intent surgery is superior to nonsurgical treatment among GBC patients with CTMLD remains to be explored in future prospective studies.
The impact of preexisting comorbidities on receipt of cancer therapy among women with Stage I–III breast cancer in the Detroit Research on Cancer Survivors cohort
Authors: Raychaudhuri Sreejata , Kyko Jaclyn M. , Ruterbusch Julie J. , Pandolfi Stephanie S. , Beebe‐Dimmer Jennifer L. , Schwartz Ann G. , Simon Michael S. 
Published: August 2023

AbstractPurposePre‐existing comorbidities play an important role in choice of cancer treatment. We retrospectively evaluated the relationship between pre‐existing comorbidities and receipt of local and systemic therapy in a cohort of Black women with Stage I–III breast cancer.MethodsThe study population for analysis included 1169 women with Stage I–III disease enrolled in the Detroit Research on Cancer Survivors (ROCS) cohort. Information on comorbidities, socio‐demographic, and clinical variables were obtained from self‐reported questionnaires and the cancer registry. Comorbidities were analyzed individually, and comorbidity burden was categorized as low (0–1), moderate (2–3) or high (≥4). We used logistic regression analysis to evaluate factors associated with receipt of local treatment (surgery ± radiation; N = 1156), hormonal (N = 848), and chemotherapy (N = 680). Adjusted models included variables selected a priori that were significant predictors in univariate analysis.ResultsReceipt of treatment was categorized into local (82.6%), hormonal (73.7%), and/or chemotherapy (79.9%). Prior history of arthritis and depression were both associated with a lower likelihood to receive local treatment, [odds ratio (OR), 95% confidence interval (CI), 0.66, 0.47–0.93, and 0.53, 0.36–0.78], respectively. Obesity was associated with higher likelihood of receiving hormonal therapy (OR: 1.64, 95% CI: 1.19, 2.26), and heart failure a lower likelihood (OR: 0.46, 95% CI: 0.23, 0.90). Older age (Ptrend <0.01) and increasing co‐morbidity burden (Ptrend = 0.02) were associated with lower likelihood of receiving chemotherapy.ConclusionHistory of prior co‐morbidities has a potentially detrimental influence on receipt of recommended cancer‐directed treatment among women with Stage I–III breast cancer.
Effect of Ultrasonic Treatment on Structure, Antibacterial Activity of Sugarcane Leaf Polysaccharides
Authors: Mo Meng‐Miao , Chen Wei‐Ming , Jiang Feng‐Yu , Ding Zhen‐Dong , Bi Yong‐Guang , Kong Fan‐Sheng 
Published: August 2023

AbstractThis study investigated the impact of ultrasonic extraction (UE) on the structure and in vitro antibacterial activity of polysaccharides from sugarcane leaves (SLW). Native sugarcane leaf polysaccharides were treated with ultrasound (480 W) for 3 h to yield sugarcane leaf polysaccharides (SLU). Compared to SLW (33.59 kDa), the molecular weight of SLU (13.08 kDa) was significantly decreased, while the monosaccharide composition of SLU was unchanged. The results of SEM and XRD indicated that UE significantly changed the surface morphology of SLW and destroyed its inner crystalline structure. In vitro experiments showed that SLU had stronger antibacterial activity. These findings revealed that UE treatment could alter the tertiary structure of SLW but had no impact on its primary structure. Furthermore, the antibacterial activity of SLW could be greatly enhanced after UE treatment. As a bioactive additive, SLU has great application potential in functional foods, cosmetics, and pharmaceuticals.
Phytochemicals, Essential Oils Composition and Antioxidant Activity of Astragalus spp., Phlomis olivieri and Daphne mucronata in Habitats of Central Iran
Authors: Ghorbani Leila , Golkar Pooran , Jafari Reza , Ahmadi Mohsen , Allafchian Alireza 
Published: August 2023

AbstractThis study evaluated several secondary metabolites, essential oils (EOs) compositions, and antioxidant activity in four medicinal plants that originated in Isfahan rangelands. The species were Astragalus verus, Astragalus adscendens, Daphne mucronata, and Phlomis olivieri. Thirty‐two genotypes of these species were evaluated for different biochemical traits. Based on the evaluation of EOs compounds, GC/MS analysis revealed the total number of identified compounds. These compounds were 25, 22, 12, and 22 for A. adscendens, A. verus, D. mucronata, and P. olivieri, respectively. The dominant compounds were phthalate (59.88 %) in A. adscendens, phytol (38.02 %) in A. verus, hexanoic acid (32.05 %) in D. mucronata and β‐cubebene (30.94 %) in P. olivieri. Phytochemical analysis showed that D. mucronata, A. adscendens, and P. olivieri had the highest total phenolics content (TPC) (18.24 mg gallic acid equivalent/g dry weight), total flavonoids content (5.57 mg QE/g DW), and total anthocyanins content (0.23 mg/g DW), respectively. The highest total chlorophyll (0.27 mg/g DW), total carotenoids (0.03 mg/g DW), and antioxidant activity (71.36 %) were observed in A. adscendens, A. adscendens and A. verus, respectively. Among all genotypes, the highest TPC (20.1 mg GAE/g DW) was observed in genotype 5 of D. mucronata. This study provided new information on the chemical compounds within the distribution range of these ecologically dominant rangeland species in Isfahan province, Iran. The data revealed that superior genotypes from these species are rich in natural antioxidants and bioactive compounds. Thus, they can be used in ethno pharmacological fields, food, and industrial applications.
Long‐lasting mood deterioration following transcranial direct current stimulation treatment for fibromyalgia: A case report
Authors: Rahimibarghani Sarvenaz , Fateh Hamid R. 
Published: August 2023

Key Clinical MessageWhile tDCS has been studied as a safe and effective tool for managing pain in fibromyalgia, there is a possibility of triggered long‐lasting mood changes. TDCS may potentially negatively affect mood in specific individuals with fibromyalgia.AbstractTranscranial direct current stimulation (tDCS) is a noninvasive neuromodulator that showed promising results in pain reduction among individuals with fibromyalgia (FM). Despite the potential benefits, it may have some adverse events that are mainly transient. However, long‐lasting effects can also occur. We presented a 31‐year‐old man whose symptoms and signs were consistent with fibromyalgia, and he received tDCS over C3 to reduce diffuse pain. Although, immediately after fulfilling the session, he became restless, agitated, and aggressive, and his symptoms lasted approximately 2 months later.
Positioning a Measurement System for Determining the Mixing Quality in Biogas Digesters
Authors: Huber Bernhard , Krebs Georg Johann , Putra Lingga Aksara , Gaderer Matthias 
Published: August 2023

AbstractMixing quality in agricultural biogas plants is crucial for nutrition supply to the microorganisms and needs to be ensured by an energy‐efficient mixing strategy. Various approaches have been proposed to determine the mixing quality in biogas digesters. Among them are magnetic‐inductive or force sensors brought into vertical digesters through the concrete wall. This article presents an approach to locating these sensors effectively around the circumference of the digester to avoid positioning in dead zones and maximize information quality regarding flow and mixing behavior. Particle image velocimetry is used to measure flow fields in a transparent model digester. Finally, optimum measurement locations considering three widely used agitator geometries are suggested.