bluuebunny/crossref_metadata_2025_split huggingface dataset:
Low oscillatory shear stress regulates Weibel-Palade body size and vWF release
Authors: Money Ashley , Todd Harriet J , Jo Hanjoong , Beech David J , McKeown Lynn 
Published: May 2023

AbstractBlood flow regulates vascular function by generating wall shear stress which impacts endothelial cell (EC) physiology. Whilst high laminar shear stress (HSS) maintains the functional integrity of the vasculature, low oscillatory shear stress (LOSS) evokes secretion of pro-thrombotic and pro-inflammatory components from ECs, thus promoting the development of cardiovascular disease (CVD). Pro-thrombotic and pro-inflammatory cargo are readily stored in endothelial-specific organelles termed Weibel-Palade bodies (WPBs). WPBs form purely due to the multimerization of the pro-thrombotic glycoprotein von Willebrand factor (vWF). Here we investigated if aberrant shear stress, induced by non-uniform oscillatory flow, modulates the biogenesis of WPBs, and the subsequent release of vWF. Ultimately, we demonstrate, using anin vitromodel, that LOSS has no effect on the level of vWF expression, however, LOSS promotes endothelial thrombotic potential by increasing WPB size, which impacts the length of the vWF strings that are released upon stimulation. Thus, wall shear stress can confer functional plasticity to WPBs by manipulating their biogenesis. Further understanding of the underlying mechanisms could aid generation of novel therapeutics in CVD.
Bilayer tension-induced clustering of the UPR sensor IRE1
Authors: Hossain Md Zobayer , Stroberg Wylie 
Published: May 2023

AbstractThe endoplasmic reticulum acts as a protein quality control center where a range of chaperones and foldases facilitates protein folding. IRE1 is a sensory trans-membrane protein that transduces signals of proteotoxic stress by forming clusters and activating a cellular program called the unfolded protein response (UPR). Recently, membrane thickness variation due to membrane compositional changes have been shown to drive IRE1 cluster formation, activating the UPR even in the absence of proteotoxic stress. Here, we demonstrate a direct relationship between bilayer tension and UPR activation based on IRE1 dimer stability. The stability of the IRE1 dimer in a (50%DOPC-50%POPC) membrane at different applied bilayer tensions was analyzed via molecular dynamics simulations. The potential of mean force for IRE1 dimerization predicts a higher concentration of IRE1 dimers for both tensed and compressed ER membranes. This study shows that IRE1 may be a mechanosensitive membrane protein and establishes a direct biophysical relationship between bilayer tension and UPR activation.HighlightsMechanical perturbation of the ER membrane favor oligomerization.Both tension and compression promote IRE1 dimer formation.IRE1 is mechanosensitive, potentially the UPR to changes in ER membrane tension and compression.
Activity of FoxP2-positive neurons is associated with tadpole begging behavior
Authors: Ludington Sarah C. , McKinney Jordan E. , Butler Julie M. , Goolsby Billie C. , Callan Ashlyn A. , Gaines-Richardson Maiah , O’Connell Lauren A. 
Published: May 2023

AbstractMotor function is a critical aspect of social behavior in a wide range of taxa. The transcription factor FoxP2 is well studied in the context of vocal communication in humans, mice, and songbirds, but its role in regulating social behavior in other vertebrate taxa is unclear. We examined the distribution and activity of FoxP2-positive neurons in tadpoles of the mimic poison frog (Ranitomeya imitator). In this species, tadpoles are reared in isolated plant nurseries and are aggressive to other tadpoles. Mothers provide unfertilized egg meals to tadpoles that perform a begging display by vigorously vibrating back and forth. We found that FoxP2 is widely distributed in the tadpole brain and parallels the brain distribution in mammals, birds, and fishes. We then tested the hypothesis that FoxP2-positive neurons would have differential activity levels in begging or aggression contexts compared to non-social controls. We found that FoxP2-positive neurons showed increased activation in the striatum and cerebellum during begging and in the nucleus accumbens during aggression. Overall, these findings lay a foundation for testing the hypothesis that FoxP2 has a generalizable role in social behavior beyond vocal communication across terrestrial vertebrates.
Distinct excitability of thalamocortical neurons correlates with the presence of cerebellar afferents
Authors: Moreno Myriam , Minjarez Crystal , Todorovic Slobodan M. , Quillinan Nidia 
Published: May 2023

AbstractThalamocortical (TC) neurons within the ventrolateral thalamus (VL) receive projections from the cerebellum and the basal ganglia (BG) to facilitate motor and non-motor functions. Tonic and rebound firing patterns in response to excitatory cerebellar and inhibitory BG inputs, respectively, are a canonical feature of TC neurons and plays a key role in signal processing. The intrinsic excitability of TC neurons has a strong influence on how they respond to synaptic inputs, however, it is unknown whether their afferents influence their firing properties. Understanding the input-specific firing patterns could shed light into movement disorders with cerebellar or BG involvement. Here, we used whole-cell electrophysiology in brain slices from C57BL/6 mice to investigate the firing of TC neurons with optogenetic confirmation of cerebellar or BG afferents. TC neurons with cerebellar afferents exhibited higher tonic and rebound firing rates than those with BG afferents. This increased firing was associated with faster action potential depolarization kinetics and a smaller afterhyperpolarization potential. We also found differences in the passive membrane properties and sag currents during hyperpolarization. Despite higher rebound firing in TC neurons with cerebellar afferents, there were no differences in T-type calcium channel function compared to those with BG inputs. These data suggest input-specific differences in sodium and SK, but not T-type calcium channels, impact firing properties in TC populations. Altogether, we showed that the pronounced divergence observed in TC neuron firing properties correlate with its heterogeneous anatomical connectivity, which could signify a distinct signal integration and processing by these neurons.KeypointsThalamocortical neurons in the VL with cerebellar afferents have higher intrinsic tonic and rebound firing properties than those with basal ganglia afferents.Membrane resistance and action potential depolarization slope were different based on the presence of cerebellar afferents.Despite elevated rebound burst firing, T-type mediated currents did not correlate with increased firing in neurons with cerebellar afferents.
Nde1 Promotes Lis1-Mediated Activation of Dynein
Authors: Zhao Yuanchang , Oten Sena , Yildiz Ahmet 
Published: May 2023

AbstractCytoplasmic dynein is the primary motor that drives the motility and force generation functions towards the microtubule minus end. The activation of dynein motility requires its assembly with dynactin and a cargo adaptor. This process is facilitated by two dynein-associated factors, Lis1 and Nde1/Ndel1. Recent studies proposed that Lis1 rescues dynein from its autoinhibited conformation, but the physiological function of Nde1/Ndel1 remains elusive. Here, we investigated how human Nde1 and Lis1 regulate the assembly and subsequent motility of the mammalian dynein/dynactin complex using in vitro reconstitution and single molecule imaging. We found that Nde1 promotes the assembly of active dynein complexes in two distinct ways. Nde1 competes with the α2 subunit of platelet activator factor acetylhydrolase (PAF-AH) 1B, which recruits Lis1 as a noncatalytic subunit and prevents its binding to dynein. Second, Nde1 recruits Lis1 to autoinhibited dynein and promotes Lis1-mediated assembly of dynein-dynactin-adaptor complexes. However, excess Nde1 inhibits dynein, presumably by competing against dynactin to bind the dynein intermediate chain. The association of dynactin with dynein triggers Nde1 dissociation before the initiation of dynein motility. Our results provide a mechanistic explanation for how Nde1 and Lis1 synergistically activate the dynein transport machinery.
The COVID-19 pandemic, economic policy uncertainty and the hedging role of cryptocurrencies: a global perspective
Authors: Aftab Muhammad , Haq Inzamam Ul , Albaity Mohamed 
Published: May 2023

PurposeThe COVID-19 pandemic has led to global economic policy uncertainty, which has increased the need to investigate ways to mitigate the uncertainty. This study aims to examine the potential of cryptocurrencies as a hedge and safe haven avenue against economic policy uncertainty.Design/methodology/approachThis study investigates the behavior of the five leading cryptocurrencies in relation to country-level and group-level economic policy uncertainty indices, as measured by the text-based method developed by Baker et al. (The Quarterly Journal of Economics, 2016, 131, 1593–1636). The research covers a broad range of emerging and developed economies from July 2013 to September 2020. The study employs the approach of Narayan et al. (Economic Modelling, 2016, 53, 388–397) to examine the hedging and safe-haven properties of cryptocurrencies.FindingsThis study finds that the top cryptocurrencies play a hedging role against economic policy uncertainty, with some exceptions. Additionally, there is evidence to support the idea that cryptocurrencies can serve as a safe haven during the COVID-19 pandemic. As a result, investors may benefit from using cryptocurrencies as a risk-management avenue during times of uncertainty.Originality/valueThis research contributes to the existing literature by testing the cryptocurrencies' hedging and safe haven properties in a new way, by analyzing their lead and lag behaviors using a recent and innovative approach. Additionally, it examines a wide range of emerging and advanced markets, providing insight into the potential of using cryptocurrencies as a risk mitigation avenue.
Robust adaptive control of nonlinear dynamic systems using hybrid sliding mode regressive neural learning technique
Authors: Anh Ho Pham Huy , Dat Nguyen Tien 
Published: May 2023

Purpose The proposed Sliding Mode Control-Global Regressive Neural Network (SMC-GRNN) algorithm is an integration of Global Regressive Neural Network (GRNN) and Sliding Mode Control (SMC). Through this integration, a novel structure of GRNN is designed to enable online and. This structure is then combined with SMC to develop a stable adaptive controller for a class of nonlinear multivariable uncertain dynamic systems.Design/methodology/approach In this study, a new hybrid (SMC-GRNN) control method is innovatively developed.Findings A novel structure of GRNN is designed that can be learned online and then be integrated with the SMC to develop a stable adaptive controller for a class of nonlinear uncertain systems. Furthermore, Lyapunov stability theory is utilized to ensure the hidden-output weighting values of SMC-GRNN adaptively updated in order to guarantee the stability of the closed-loop dynamic system. Eventually, two different numerical benchmark tests are employed to demonstrate the performance of the proposed controller.Originality/value A novel structure of GRNN is originally designed that can be learned online and then be integrated with the sliding mode SMC control to develop a stable adaptive controller for a class of nonlinear uncertain systems. Moreover, Lyapunov stability theory is innovatively utilized to ensure the hidden-output weighting values of SMC-GRNN adaptively updated in order to guarantee the stability of the closed-loop dynamic system.
An adaptive binary-tree subdivision method for evaluation of nearly singular integrals in 3D BEM
Authors: Ju Chuanming , Zhang J. , Zhong Yudong , Du Xianfeng , Li Jun , Chi Baotao 
Published: May 2023

PurposeThe purpose of this paper is to present an adaptive binary-tree element subdivision method (BTSM) for the evaluation of nearly singular integrals in three-dimensional boundary element method, which can facilitate automatic and high-quality patch generation.Design/methodology/approachIn this method, the nearly singular element is split into two sub-elements. Each sub-element is then examined to determine if it is to be subdivided based on a specific subdivision criterion. The specific subdivision ensures that those sub-elements far from the source point are sparse. And then those sub-elements in close proximity to the source point are replaced by regular triangular elements.FindingsWith the proposed method, the sub-elements obtained are automatically refined as they approach the projection point, and they are “good” in shape and size for standard Gaussian quadrature. Thus, the proposed method can be used to evaluate nearly singular integrals accurately for cases of different element shapes and various locations of the source point.Originality/valueNumerical examples for surface elements with various relative locations of the source point are presented. The results demonstrate that the proposed method has much better accuracy and robustness than some other methods.
Social media and the bottom of the pyramid: a systematic literature review and future research agenda
Authors: Kumar Jitender , Tapar Archit Vinod , Bhattacharjee Somraj 
Published: May 2023

PurposeThe study aims to present a systematic literature review (SLR) to understand the current status of research on social media usage among the bottom of the pyramid (BOP). The purpose of this study is to identify the research gaps in this domain and review future research agendas by using theory, context, characteristics and methods [TCCM] framework.Design/methodology/approachAn SLR, keywords co-occurrence and TCCM analysis were used to analyse and synthesize insights from 44 studies gained from Web of Science and Scopus databases.FindingsThe findings suggest that the USA and India are popular contexts for studying BOP. The BOP population uses social media to gain utilitarian, hedonic and social values. Further, social media can help BOP explore “entrepreneurship” opportunities, value co-creation and bring innovations.Originality/valueThis study expands the intellectual boundaries of social media at BOP and suggests multidisciplinary research. Additionally, adopting novel theoretical lenses helped determine social media's impact on BOP.
Tackling social exclusion through engagement in football: findings from the “Kickstart 2 Recovery” programme
Authors: Tuite Amy Maria , Nolan Clodagh , Johnston Jenny , Dillon Maurice 
Published: May 2023

Purpose
This study aims to determine whether engagement in a football programme can positively impact the recovery journey of the mental health service users involved from the perspective of the “Kickstart 2 Recovery” (K2R) programme stakeholders. There are many challenges faced by the people with mental health problems, a significant one being social exclusion. Football is a socially valued occupation in Ireland (Moran, 2019) and the K2R programme is an initiative run to combat experiences of isolation and exclusion that those with mental health difficulties may experience.

Design/methodology/approach
A descriptive phenomenological approach was taken to the study with the use of semi-structured interviews as the research method. In total, twenty one interviews were carried out and Braun and Clarke’s (2006) thematic analysis was used to analyse the data.

Findings
Two themes represent the findings of this paper: the need for pathways and social inclusion, connection and flexibility. These reveal that facilitators are focused on supporting recovery but are unsure of how to overcome barriers to social inclusion. Sports partnerships and programme facilitators have a role to play in accessing community resources, challenging social stigma and creating exit pathways from the group.

Originality/value
This study reveals the challenges footballers with mental health difficulties experience when attempting to become more included in their communities and suggestions on how football programmes, such as K2R, could support their inclusion. These findings add to the body of research analysing the issue of social inclusion for people with mental health difficulties.
Health performance and economic growth in sub-Saharan Africa: new evidence based on quantile regressions
Authors: Asongu Simplice , Odhiambo Nicholas M. 
Published: May 2023

PurposeThe present study investigates the nexus between health performance dynamics and economic growth in 43 countries in sub-Saharan Africa for the period 2004–2018.Design/methodology/approachFour health performance dynamics are used, notably: total life expectancy, male life expectancy, female life expectancy and risk of maternal death. The empirical evidence is based on quantile regressions (QRs) in order to put into perspective the conditional distribution of economic growth.FindingsThe following findings are established: (1) total life expectancy and male life expectancy increase economic growth exclusively in the 10th and 90th quantiles of economic growth; (2) female life expectancy boosts economic growth in the 90th quantile of economic growth and (3) the risk of maternal death reduces economic growth in the 75th and 90th quantiles of economic growth. Policy implications are discussed.Originality/valueThe study complements the literature on the nexus between health performance and economic growth by assessing the nexuses throughout the conditional distribution of economic growth.
Theory of repeat purchase behavior (TRPB): a case of green hotel visitors of Bangladesh
Authors: Hasan Abdulla Al-Towfiq 
Published: May 2023

Purpose
This study aims to explore customers’ green hotel revisit behaviors, proposing the theory of repeat purchase behavior.

Design/methodology/approach
An empirical study is conducted through a questionnaire survey method, using personal interview survey approach in Bangladesh. In all, 401 usable data is collected from participants who have visited green hotels before. The following data are analyzed through partial least squares structural equation modeling (PLS-SEM) using Smart PLS 3.3.3.

Findings
Results of the study have raveled that habitual attachment and emotional attachment are significantly related to green hotel revisit intentions (behavioral intention) and revisiting a green hotel (actual behavior). The result also has uncovered that green hotel revisit intentions significantly impacted revisiting a green hotel. Moreover, the study results exert that green hotel revisit intentions partially mediate the relationship between habitual attachments, emotional attachment, and revisiting a green hotel.

Originality/value
The current study enriches green hospitality literature by uncovering the integrated effects of habitual attachment and emotional attachment on customers’ revisit intentions and behaviors in the green hotels’ context.
Short supply chain choice and impact amongst rice processors in rural Ghana
Authors: Bannor Richard Kwasi , Oppong-Kyeremeh Helena , Boateng Abigail Oparebea , Bold Ebenezer , Gruzah Barikisu 
Published: May 2023

PurposeThis paper examined the factors influencing the participation of rice processors in short supply chains and the participation impact on the amount of rice processed, per capita expenditure of household and value of sales.Design/methodology/approachThe Seemingly Unrelated Regression and Doubly Robust Augmented Inverse Probability Weighting Model (AIPW) were used to analyse the determinants of short supply chain participation and the impact of short supply.FindingsFrom the results, the mean value of rice processed was GH₵18385 (US$ 3,069.28), with the minimum value being GH₵ 25 (US$ 4.17) and the maximum GH₵ 67200 (US$ 1,1218.70) per annum. Processed rice aroma and grade characteristics positively influence the value of processed rice sold via short supply chains as well as the expertise rate of the processor, Farmer-Based Organisation membership, and marketing information availability. Women rice processors' per capita expenditure, total sales value and the value of processed rice was positively influenced by the short supply chain participation.Research limitations/implicationsEven though the sample size was appropriate, a larger sample size could further support the study's finding since a limited geographical area with predominant domestic rice processors was studied. Again, future studies should consider behavioural theories, such as the Theory of Planned Behaviour, amongst others, in understanding the reasons for the choices of short supply chains compared to other sales outlets.Originality/valueAlthough there is a growing body of literature on rice, most of the studies focussed on the marketing outlet of rice producers, rice processing, constraints and opportunities faced by rice farmers and processors and an out-grower scheme involving rice processors amongst rice producers with none of these on the choice of short supply chains amongst women processors. Also, amongst all the studies on rice producers, none applied a theory; however, the Women in Development (WID) Theory was used to analyse the impact of the short supply chain on the impact on household per capita expenditure (poverty), the value of sales and amount of rice processed, a modest theoretical contribution of the paper to literature.
Human rights and older people: process and perspectives
Authors: Penhale Bridget 
Published: May 2023

Purpose
This paper aims to provide an overview and viewpoint on current international initiatives relating to the human rights of older people.

Design/methodology/approach
The paper provides a review of recent and current developments in relation to the human rights of older people and some discussion of these issues.

Findings
In addition to the UN Universal Declaration of Human Rights, there are separate conventions on the rights of women, children and persons with disabilities. However, there is currently no universal, binding legal instrument on the human rights of older people, although work is in progress at international level in an attempt to remedy this lack.

Research limitations/implications
This brief paper aims to provide an overview of a complex current issue for those not familiar with the topic, so it is not able to provide an in-depth analysis of the topic.

Practical implications
Social workers and other human services professionals, particularly those who work with older adults, including those working in the health-care sector, should have knowledge and understanding about this important issue.

Social implications
Many older people face inequalities that result from existing gaps in the protection of their rights. This includes issues relating to Intersecting forms of discrimination that adversely affect some older adults. Individuals should be able to age with dignity so they can lead dignified, self-determined and secure lives – and need protection of their human rights to enable them to do so.

Originality/value
This paper provides a viewpoint on current international initiatives concerning the human rights of older people.