bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unmet supportive care needs among informal caregivers of patients with head and neck cancer in the first 2 years after diagnosis and treatment: a prospective cohort study
Authors: van Hof Kira S. , Hoesseini Arta , Dorr Maarten C. , Verdonck - de Leeuw Irma M. , Jansen Femke , Leemans C. Réne , Takes Robert P. , Terhaard Chris H. J. , de Jong Robert J. Baatenburg , Sewnaik Aniel , Offerman Marinella P. J. 
Published: April 2023

Abstract
Objective
Informal caregivers of head and neck cancer (HNC) patients have a high caregiver burden and often face complex practical caregiving tasks. This may result in unmet supportive care needs, which can impact their quality of life (QoL) and cause psychological distress. In this study, we identify caregivers’ unmet needs during long-term follow-up and identify caregivers prone to unmet supportive care needs.

Methods
Data were used from the multicenter prospective cohort study NETherlands QUality of life and Biomedical cohort studies In Cancer (NET-QUBIC). The unmet supportive care needs, psychological distress, caregiver burden, and QoL were measured for 234 informal caregivers and their related patients at baseline, 3, 6, 12, and 24 months after. Mixed effect models for repeated measurements were used.

Results
At baseline, most caregivers (70.3%) reported at least one unmet supportive care need, with most of the identified needs in the “healthcare & illness” domain. During the follow-up period, caregivers’ unmet needs decreased significantly in all domains. Nevertheless, 2 years after treatment, 28.3% were still reporting at least one unmet need. Financial problems were increasingly associated with unmet needs over time. Furthermore, caring for a patient who themselves had many unmet needs, an advanced tumor stage, or severe comorbidity was associated with significantly more unmet needs in caregivers.

Conclusions
The current study shows the strong likelihood of caregivers of HNC patients facing unmet supportive care needs and the interaction between the needs of patients and caregivers. It is important to optimally support informal caregivers by involving them from the start when counseling patients, by providing them with relevant and understandable information, and by referring vulnerable caregivers for (psychosocial) support.
Late adverse events in patients with pelvic cancer after oncologic treatment—intervention and treatment effect
Authors: Iselius Sofia , Knutsen Annica , Mikiver Rasmus , Uppugunduri Srinivas 
Published: April 2023

Abstract

Purpose
Few studies have focused on the late adverse events after oncologic treatment in pelvic cancer patients. Here, the treatment effect/interventions were studied on late side effects as GI, sexual, and urinary symptoms in pelvic cancer patients who visited a highly specialized rehabilitation clinic in Linköping.

Methods
This retrospective longitudinal cohort study included 90 patients who had at least one visit at the rehabilitation clinic for late adverse events at Linköping University hospital between 2013 to 2019. The toxicity of the adverse events was analyzed by using the common terminology criteria for adverse events (CTCAE).

Results
By comparing the toxicity of symptoms between visits 1 and 2, we showed that the GI symptoms decreased with 36.6% (P = 0.013), the sexual symptoms with 18.3% (P < 0.0001), and urinary symptoms with 15.5% (P = 0.004). Patients who received bile salt sequestrant had a significant improvement in grade of GI symptoms as diarrhea/fecal incontinence at visit 2 compared to visit 1 where 91.3% were shown to have a treatment effect (P = 0.0034). The sexual symptoms (vaginal dryness/pain) significantly improved due to local estrogens between visits 1 and 2 where 58.1% had a reduction of symptoms (P = 0.0026).

Conclusion
The late side effects as GI, sexual, and urinary symptoms was significantly reduced between visits 1 and 2 at the specialized rehabilitation center in Linköping. Bile salt sequestrants and local estrogens are effective treatments for side effects as diarrhea and vaginal dryness/pain.
Effect of intraoperative remimazolam on postoperative sleep quality in elderly patients after total joint arthroplasty: a randomized control trial
Authors: Deng Chun-Mei , Meng Zhao-Ting , Yang Jing , Zhang Cai-Juan , Lu Min , Wang Yue-Xin , Mu Dong-Liang 
Published: April 2023

Abstract
Purpose
To investigate the effect of intraoperative remimazolam sedation on postoperative sleep quality in elderly patients after total joint arthroplasty.

Methods
Between May 15, 2021 and March 26, 2022, 108 elderly patients (age ≥ 65 years) who received total joint arthroplasty under neuraxial anesthesia were randomized into remimazolam group (a loading dose of 0.025–0.1 mg/kg and followed by an infusion rate of 0.1–1.0 mg/kg/h till end of surgery) or routine group (sedation was given on patient’s requirement by dexmedetomidine 0.2–0.7 μg/kg/h). Primary outcome was the subjective sleep quality at surgery night which was evaluated by Richards Campbell Sleep Questionnaire (RCSQ). Secondary outcomes included RCSQ scores at postoperative first and second nights and numeric rating scale pain intensity within first 3 days after surgery.

Results
RCSQ score at surgery night was 59 (28, 75) in remimazolam group which was comparable with 53 (28, 67) in routine group (median difference 6, 95% CI − 6 to 16, P = 0.315). After adjustment of confounders, preoperative high Pittsburg sleep quality index was associated worse RCSQ score (P = 0.032), but not remimazolam (P = 0.754). RCSQ score at postoperative first night [69 (56, 85) vs. 70 (54, 80), P = 0.472] and second night [80 (68, 87) vs. 76 (64, 84), P = 0.066] were equivalent between two groups. Safety outcomes were comparable between the two groups.

Conclusions
Intraoperative remimazolam did not significantly improve postoperative sleep quality in elderly patients undergoing total joint arthroplasty. But it is proved to be effective and safe for moderate sedation in these patients.

Clinical trial number and registry URL
ChiCTR2000041286 (www.chictr.org.cn).
Psychische Gesundheit in der Schule
Authors: Bilz Ludwig 
Published: April 2023

ZusammenfassungDer psychischen Gesundheit von Kindern und Jugendlichen ist in den letzten Jahrzehnten verstärkte Aufmerksamkeit zuteil geworden. Immer deutlicher zeichnet sich ab, dass psychische Probleme im Kindes- und Jugendalter eine hohe Vorhersagekraft für psychische Erkrankungen im Erwachsenenalter haben. Gleichzeitig verfügen wir über einen immer breiter werdenden Erkenntnisstand zur Bedeutung des psychischen Wohlbefindens von Kindern und Jugendlichen für ihren schulischen Erfolg und für ihre soziale Teilhabe. Der vorliegende Beitrag nimmt die Lebenswelt Schule in das Blickfeld. Es werden Befunde zu schulbezogenen Ressourcen und Risikofaktoren für die psychische Gesundheit von Schüler*innen und zur Rolle von Lehrkräften bei der Früherkennung vorgestellt sowie Schlussfolgerungen für die Förderung der psychischen Gesundheit in der Schule gezogen.
Positionspapier zur schul- und kindergartenbasierten Ergotherapie
Authors: Ulbrich-Ford Sophie , Morgenthaler Thomas 
Published: April 2023

ZusammenfassungZiel der schul- und kindergartenbasierten Ergotherapie ist es, die Inklusion und Partizipation gemeinsam mit den Pädagog*innen direkt im Klassenzimmer im Schulsetting für Kinder zu ermöglichen. So soll ein wesentlicher Beitrag zur Umsetzung der UN-Konvention zu den Rechten von Menschen mit Behinderung geleistet werden. Ergotherapie steht Kindern und Jugendlichen, die Alltagsschwierigkeiten haben, derzeit nur außerhalb der Schule oder des Kindergartens zur Verfügung. Vereinzelt gibt es bereits Projekte innerhalb des österreichischen Bildungssettings. Ergotherapeut*innen stehen hierfür eine Vielzahl an Befundungsmöglichkeiten und Interventionen zur Verfügung. In Österreich steht eine Umsetzung aber noch vor vielen Herausforderungen aufgrund rechtlicher Strukturen und aufgrund der Finanzierung.
Perioperative morbidity and mortality in octogenarians sustaining traumatic osteoporotic type 4 and 5 thoracolumbar and lumbar fractures: a retrospective study with 3 years follow-up
Authors: Lenga Pavlina , Gülec Gelo , Kiening Karl , Unterberg Andreas W. , Ishak Basem 
Published: April 2023

Abstract
Purpose
This study aimed to guide the more efficient management of type 4 and 5 thoracolumbar or lumbar osteoporotic fractures (OF) in patients aged 80 years and older with an acute onset of neurological decline. This aim was achieved by assessing the clinical course and morbidity and mortality rates and identifying potential risk factors for patient mortality

Methods
Electronic medical records were retrieved from a single institution pertaining to the period between September 2005 and December 2020. Data on patient demographics, neurological conditions, surgical characteristics, complications, hospital course, and 90-day mortality were also collected.

Results
Over a 16-year period, 35 patients aged ≥80 years diagnosed with thoracolumbar and lumbar OF were enrolled in the study. The mean Charlson comorbidity index (CCI) was >6, indicating a poor baseline reserve (9.4 ± 1.9), while cardiovascular diseases were the most prevalent among comorbidities. The mean surgical duration was 231.6 ± 89.3 min, with a mean blood loss of 694.4± 200.3 mL. The in-hospital was 8.6% and 90-day mortality rates at 11.4%. Two patients underwent revision surgery for deep wound infection. Intraoperative and postoperative radiography and computed tomography (CT) imaging revealed correct screw placement. Proper alignment of the thoracolumbar spine was achieved in all the patients. Unique risk factors for mortality included the presence of comorbidities and the occurrence of postoperative complications.

Conclusions
Emergent instrumentation in patients with acute onset of neurological decline and potentially unstable spines due to thoracolumbar and lumbar OF improved functional outcomes at discharge. Age should not be a determinant of whether to perform surgery.
Committing to change? A case study on volunteer engagement at a New Zealand urban farm
Authors: Kelly Daniel C. 
Published: April 2023

AbstractUrban agriculture is a promising avenue for food system change; however, projects often struggle with a lack of volunteers—limiting both their immediate goals and the broader movement-building to which many alternative food initiatives (AFIs) aspire. In this paper, I adopt a case study approach focusing on Farm X, an urban farm with a strong volunteer culture located in Tāmaki-Makaurau Auckland, New Zealand’s largest city. Drawing on a significant period of researcher participation and 11 in-depth interviews with volunteers and project coordinators, I first contextualise and explore the history of Farm X, then offer themes to describe key factors which help or hinder their volunteer engagement. Engagement is helped by strong leadership, learning by doing, socialising around plants, and contributing to a movement. Conversely, engagement is hindered by time scarcity, economic hurdles, and struggles over direction. Drawing on McClintock’s (Local Environ 19(2): 147–171, 2014, 10.1080/13549839.2012.752797) insights into the hybrid and contradictory nature of urban agriculture as a tool for social change, the paper continues with a discussion of two important trade-offs involved in both farm management and the movement building promoted by Farm X: focused leadership verses volunteer agency; and asking more verses less of volunteers. Finally, I suggest several avenues that may be useful for other urban agriculture projects interested in movement building.
Effect of ultra-violet light radiation on Scenedesmus vacuolatus growth kinetics, metabolic performance, and preliminary biodegradation study
Authors: Eregie Stella B. , Sanusi Isaac A. , Kana Gueguim E. B. , Olaniran Ademola O. 
Published: April 2023

AbstractThis study presents the effect of ultra-violet (UV) light radiation on the process kinetics, metabolic performance, and biodegradation capability of Scenedesmus vacuolatus. The impact of the UV radiation on S. vacuolatus morphology, chlorophyll, carotenoid, carbohydrates, proteins, lipid accumulation, growth rate, substrate affinity and substrate versatility were evaluated. Thereafter, a preliminary biodegradative potential of UV-exposed S. vacuolatus on spent coolant waste (SCW) was carried out based on dehydrogenase activity (DHA) and total petroleum hydrocarbon degradation (TPH). Pronounced structural changes were observed in S. vacuolatus exposed to UV radiation for 24 h compared to the 2, 4, 6, 12 and 48 h UV exposure. Exposure of S. vacuolatus to UV radiation improved cellular chlorophyll (chla = 1.89-fold, chlb = 2.02-fold), carotenoid (1.24-fold), carbohydrates (4.62-fold), proteins (1.44-fold) and lipid accumulations (1.40-fold). In addition, the 24 h UV exposed S. vacuolatus showed a significant increase in substrate affinity (1/Ks) (0.959), specific growth rate (µ) (0.024 h−1) and biomass accumulation (0.513 g/L) by 1.50, 2 and 1.9-fold respectively. Moreover, enhanced DHA (55%) and TPH (100%) degradation efficiency were observed in UV-exposed S. vacuolatus. These findings provided major insights into the use of UV radiation to enhance S. vacuolatus biodegradative performance towards sustainable green environment negating the use of expensive chemicals and other unfriendly environmental practices.
Graphical abstract
Repurposing antidiabetic drugs for rheumatoid arthritis: results from a two-sample Mendelian randomization study
Authors: Qin Chenxi , Diaz-Gallo Lina-Marcela , Tang Bowen , Wang Yunzhang , Nguyen Thuy-Dung , Harder Arvid , Lu Yi , Padyukov Leonid , Askling Johan , Hägg Sara 
Published: April 2023

AbstractDespite increasing therapeutic options to treat rheumatoid arthritis (RA), many patients fail to reach treatment targets. The use of antidiabetic drugs like thiazolidinediones has been associated with lower RA risk. We aimed to explore the repurposing potential of antidiabetic drugs in RA prevention by assessing associations between genetic variation in antidiabetic drug target genes and RA using Mendelian randomization (MR). A two-sample MR design was used to estimate the association between the antidiabetic drug and RA risk using summary statistics from genome-wide association studies (GWAS). We selected independent genetic variants from the gene(s) that encode the target protein(s) of the investigated antidiabetic drug as instruments. We extracted the associations of instruments with blood glucose concentration and RA from the UK Biobank and a GWAS meta-analysis of clinically diagnosed RA, respectively. The effect of genetic variation in the drug target(s) on RA risk was estimated by the Wald ratio test or inverse-variance weighted method. Insulin and its analogues, thiazolidinediones, and sulfonylureas had valid genetic instruments (n = 1, 1, and 2, respectively). Genetic variation in thiazolidinedione target (gene: PPARG) was inversely associated with RA risk (odds ratio [OR] 0.38 per 0.1mmol/L glucose lowering, 95% confidence interval [CI] 0.20–0.73). Corresponding ORs (95%CIs) were 0.83 (0.44–1.55) for genetic variation in the targets of insulin and its analogues (gene: INSR), and 1.12 (0.83, 1.49) 1.25 (0.78-2.00) for genetic variation in the sulfonylurea targets (gene: ABCC8 and KCNJ11). In conclusion, genetic variation in the thiazolidinedione target is associated with a lower RA risk. The underlying mechanisms warrant further exploration.
A systematic review of almost three decades of value sensitive design (VSD): what happened to the technical investigations?
Authors: Gerdes Anne , Frandsen Tove Faber 
Published: April 2023

AbstractThis article presents a systematic literature review documenting how technical investigations have been adapted in value sensitive design (VSD) studies from 1996 to 2023. We present a systematic review, including theoretical and applied studies that either discuss or conduct technical investigations in VSD. This systematic review contributes to the VSD community when seeking to further refine the methodological framework for carrying out technical investigations in VSD.
Catchment land use drivers are weak predictors of lakes’ phytoplankton assemblage structure at functional group level
Authors: Selmeczy Géza B. , Tapolczai Kálmán , Padisák Judit 
Published: April 2023

AbstractA number of studies evidenced the impact of human activities on aquatic environments worldwide. The availability of nutrients in lakes is strongly influenced by watershed land use patterns depending on the share of forestry, agriculture and urbanization level. Nearly all the previous studies, which examined the relationships between the phytoplankton community and the land use pattern on the watershed of lakes or reservoirs were performed on a taxonomic basis. In this study, 78 lakes were sampled to analyse how the different land use types affect their phytoplankton functional group compositions. Our results concluded that land use is a complex driver, and it cannot provide an unequivocally straightforward forecast, which could result in the selection of a specific functional group or taxa. Thus, land use alone is a weak predictor, but the shared effects may structure the phytoplankton assemblage composition.
The global ecological niche of lumpfish (Cyclopterus lumpus) and predicted range shifts under climate change
Authors: Rodríguez-Rey Marta , Whittaker Benjamin 
Published: April 2023

AbstractLumpfish are a commercially significant marine fish that are harvested in roe fisheries and used as cleaner fish in salmon farming, however, little is known of the environmental factors shaping the ecological niche of the species at global scale. As captive reared lumpfish are sensitive to warm water, the geographic distribution of wild populations may change as sea temperatures rise under expected climate change. After investigating the ecological niche of the lumpfish using Species Distribution Models, we found that nitrate concentration, ice cover, diffuse attenuation, and temperature predicted the probability of lumpfish occurrence. Through modelling distribution under expected climate change forecasts within a realistic scenario, we found reduced probability of lumpfish occurrence in areas which currently support roe harvest and cleaner fish industry. Future conservation of the species and fisheries management should account for changes in lumpfish distribution as the range shifts northward.
The Effects of Spiritual Wellbeing on Self-Perceived Health Changes Among Members of the Church of England During the COVID-19 Pandemic in England
Authors: Village Andrew , Francis Leslie J. 
Published: April 2023

AbstractThis paper tests whether changes in spiritual wellbeing were correlated with self-rated changes in mental and physical health after controlling for changes in psychological wellbeing in a sample from the Church of England taken during the third national COVID-19 lockdown in 2021. During the third lockdown in England an online survey, named Covid-19 and Church-21, was delivered through the Qualtrics XM platform from 22 January to 23 July 2021. The responses included 1878 Anglicans living in England. The change in spiritual wellbeing scale was produced using self-reported changes in the frequency of key spiritual practices (prayer and Bible reading), trust in God, the quality of spiritual life, and spiritual health. Changes in mental and physical health were assessed using single self-report items. Changes in psychological wellbeing were assessed using the Index of Balanced Affect Change (TIBACh). After controlling for changes in psychological wellbeing, better change in spiritual wellbeing was positively correlated with better change in both mental and physical health. Negative affect may have mediated the relationship between spiritual wellbeing and both mental and physical health, and positive affect may also have mediated the relationship with mental health. The results suggest changes in spiritual wellbeing, as defined within a Christian religious context, may have had positive effects in promoting better mental and physical health during a sudden crisis such as the COVID-19 pandemic.
Non-invasive Angiographic-based Fractional Flow Reserve: Technical Development, Clinical Implications, and Future Perspectives
Authors: Peper Joyce , Bots Michiel L. , Leiner Tim , Swaans Martin J. 
Published: April 2023

AbstractNew non- and less-invasive techniques have been developed to overcome the procedural and operator related burden of the fractional flow reserve (FFR) for the assessment of potentially significant stenosis in the coronary arteries. Virtual FFR-techniques can obviate the need for the additional flow or pressure wires as used for FFR measurements. This review provides an overview of the developments and validation of the virtual FFR-algorithms, states the challenges, discusses the upcoming clinical trials, and postulates the future role of virtual FFR in the clinical practice.
Revisiting the determination of Mount Olympus Height (Greece)
Authors: Ampatzidis Dimitrios , Moschopoulos Georgios , Mouratidis Antonios , Styllas Michael , Tsimerikas Alexandros , Deligiannis Vasileios-Klearchos , Voutsis Nikolaos , Perivolioti Triantafyllia-Maria , Vergos Georgios S. , Plachtova Alexandra 
Published: April 2023

AbstractThe present study deals with the determination of Mount Olympus summit (Mytikas), exploiting modern observations such as Global Navigation Satellite Systems (GNSS) and existing geodetic information. The last official Olympus height determination goes back 102 years by the Swiss surveyor M. Kurz. Since then, only unofficial measurement campaigns have taken place. There is a variety of released heights, which range from 2917 to 2919 meters. In September and October of 2022, we conducted a GNSS campaign, focusing on the area of highest Olympus peaks. Employing precise GNSS measurements (accuracy of 1–3 cm), in conjunction with height information from Greece’s National Triangulation Network (5–10 cm accuracy) and an appropriate, recent geoid model (5–6 cm accuracy), we estimate through the so-called GNSS-levelling, the height of Olympus to 2917.727 m with respect to Greece’s officially accepted mean sea level and 2918.390 m with respect to the global vertical datum. Our estimation of Olympus highest peak shows remarkable consistency at the level of 12.8 cm to that of M. Kurz in 1921.
Erweiterung der viralen Vektor-Toolbox: das Potenzial von Schimpansen-CMV
Authors: Phan Quang Vinh , Bogdanow Boris , Wiebusch Lüder 
Published: April 2023

AbstractHuman cytomegalovirus (CMV) causes severe disease in immunocompromised individuals. CMV-based vectors are promising candidates in vaccination and immunotherapy approaches. Here, we report on our approach to make chimpanzee CMV (CCMV) available for CMV research and vector development. We cloned the CCMV genome and created a global picture of the CCMV infection program by multi-omics. Via engineering distinct regions in the viral genome, we were able to modify the host cell tropism and immune evasion properties of CCMV.