bluuebunny/crossref_metadata_2025_split huggingface dataset:
Modern scientific views on multilingualism as a social and individual phenomenon: the curriculum of the discipline – 011 Educational, pedagogical sciences
Authors:   Institute of Pedagogy of the National Academy of Educational Sciences of Ukraine, Fidkevych Olena 
Published: June 2023

The work program of the discipline "Modern scientific views on multilingualism as a social and individual phenomenon" is designed for graduates of the degree "Doctor of Philosophy" in the specialties: 011 Educational, pedagogical sciences, 013 "Primary education", 014 "Secondary education (subject specializations)”. The program consists of one module. The study of the discipline is given 30 hours / 1 credit for ECTS. The program is aimed at mastering the achievements of European and Ukrainian pedagogical science in the field of multilingual education, using the experience of Western European educational systems to form multilingual competence of students (conceptual ideas, educational models, innovative learning technologies). The program defines integrated competence, general and professional competencies in accordance with the educational program. Subject results are presented, as the ability of students: –	operate with the basic concepts and categories of multilingualism as a social and individual phenomenon; –	analyze the history of multilingual education in Western Europe and Ukraine; –	to study the structure and content of multilingual education of schoolchildren in Western Europe, educational technologies for the formation of multilingualism; –	identify trends in the development of multilingual education of students in Western Europe at different levels; –	characterize the prospects of using the European experience in Ukraine and forecast its results; –	select and use modern and effective teaching methods and technologies in the field of multilingual education; –	evaluate and monitor learning outcomes in multilingual student education programs based on a competency-based approach. The program consists of two thematic blocks: "Trends in multilingualism as a social and individual phenomenon in Western Europe" and "Prospects for the use of European experience of multilingual education in Ukraine." The blocks contain 2 lectures (2 hours each) and 3 seminars (2 hours each), the topics of which are presented in the program. The title of each lecture is accompanied by a description. 20 hours are allocated for independent work - 5 topics (4 hours each). The program also defines teaching methods and control methods, provides a table of scores and a rating scale (national and ECTS). The program contains a list of references (basic and additional).
Analisis Sistem Pengendalian Internal Gaji dan Upah Pada Pengadilan Tata Usaha Negara Palembang
Authors: Khudri Akhmad , Marlina Deti 
Published: June 2023

Abstract : The Palembang State Administrative Court (PTUN) is one of the mainstays of regulatory conditions in Indonesia in its ability to complement the power of law, especially to decide issues that occur in state organizations and organizations or government businesses within the scope of South Sumatra, the Bangka Belitung Islands Region. The Palembang State Administrative Count in managing data is quite good but the way when it is going to follow transactions into an application, especially regarding the management of employee salary and wage data still looks quite complicated and difficult to operate except by the person who holds the application system. Therefore the author makes an application that is easier to operate, so that it can help when inputting salary transactions. This study uses the waterfall method and the modeling language UML (unified Modeling Language), xampp, PHP Rad classic and database.
PERANCANGAN UI/UX DESIGN PADA APLIKASI JASA FREELANCER BERBASIS ANDROID MENGGUNAKAN METODE USER CENTERED DESIGN
Authors: R I Syahril Rizal , Saputra Surya Adi 
Published: June 2023

Abstract : The growth of the information technology sector in Indonesia is relatively fast and will continue to grow, this will affect the way a business entity fulfills human resource needs to complete a project being carried out. Freelancers or freelancers are one solution for project owners who want employees to meet their human resource needs. One of the important factors in determining the success of a project undertaken by a freelancer is recruiting the right people to work on the project, but there are problems with clients towards freelancers, namely communication, turnaround time, and the payment system. So the authors took the initiative to design UI/UX Design for freelancer service applications where the application design is intended to meet 3 aspects of the problem, communication, turnaround time, and payment systems. In addition, application design is built using the UCD (User Centered Design) system development model so that applications are designed according to the objectives and meet user needs.
Prediktabilitas Sample Skewness Terhadap Return Pasar Saham Indonesia
Authors: Maksar Muhammad Sofian 
Published: June 2023

This study investigates the predictability of sample skewness on Indonesian stock market returns as represented by the JCI, LQ45, and JCI. The sample period starts from January 2001 to December 2022, with a prediction period from July 2009 to December 2022 that accommodates the COVID-19 pandemic crisis. The results showed that sample skewness was able to predict market excess returns one month in advance. This ability emerged, especially when the COVID-19 pandemic crisis hit. This finding indicates that investors tend to look for securities that have lottery-like characteristics, which causes the price of these securities to experience mispricing. However, this mispricing can be adjusted in the next period so that this strategy is not profitable to implement.
Keywords: Market return predictability, Sample skewness, Sample variance
Abstrak
Penelitian ini bertujuan untuk menginvestigasi kemampuan prediksi (prediktabilitas) sample skewness terhadap return pasar saham indonesia yang diwakili oleh IHSG, LQ45, dan JCI. Periode sampel dimulai dari Januari 2001 sampai Desember 2022 dengan periode prediksi dari Juli 2009 sampai Desember 2022 yang mengakomodir krisis pandemi Covid-19. Hasil penelitian menunjukkan bahwa sample skewness mampu memprediksi excess return pasar satu bulan ke depan. Kemampuan ini muncul khususnya saat krisis pandemi Covid-19 melanda. Temuan ini mengindikasikan bahwa investor cenderung mencari sekuritas yang memiliki karakteristik seperti lotere yang menyebabkan harga sekuritas ini mengalami mispricing. Akan tetapi, mispricing ini dapat disesuaikan di periode selanjutnya sehingga strategi ini tidak menguntungkan untuk diterapkan.
Keywords: Prediktabilitas return pasar, Sample skewness, Sample variance
Analysis of the Use of Financial Technology and Financial Literacy Among MSMEs
Authors: Utami Novia 
Published: June 2023

The massive effects of the Covid-19 pandemic and continuous technological innovations are not the only ones that change people's lives; the world is now experiencing the emergence of FinTech. FinTech is a technology-based financial service that allows financial transactions to be made quickly, anywhere, and anytime. FinTech has given MSMEs advantages, from capital financing to easy transaction processes to boost MSMEs' growth. This research aims to see how the adoption of FinTech and financial literacy affect the development of Indonesia's MSMEs. Data were used online questionnaires while samples were selected using a convenience sampling technique with 125 business owners participating in this research. Data were then analyzed using the OLS regression method. Results suggest that FinTech and financial literacy positively and significantly influence the development of MSMEs.

Keywords: Financial Technology, Financial Literacy, MSME

Abstrak
Efek terjadinya pandemi Covid19 dan inovasi teknologi yang tidak terbatas pada era digital saat ini, semakin dilengkapi dengan hadirnya FinTech. FinTech adalah layanan keuangan dengan berbasis teknologi yang memberikan kemudahan dalam bertransaksi keuangan dimanapun dan kapanpun. FinTech menjadi keunggulan tersendiri bagi UMKM, baik dari segi pembiayaan permodalan maupun kemudahan bertransaksi untuk meningkatkan perkembangan UMKM. Penelitian ini bertujuan untuk mengetahui pemanfaatan Fintech dan literasi keuangan terhadap perkembangan UMKM di Indonesia. Data dalam penelitian ini diperoleh melalui kuesioner secara online dan pengambilan sampel menggunakan teknik convenience sampling. Dengan menggunakan 125 responden pemilik usaha dan metode regresi OLS, penulis menemukan bahwa Fintech dan literasi keuangan memiliki pengaruh positif signifikan terhadap perkembangan UMKM.

Kata kunci: Financial Technology, Literasi Keuangan, UMKM
Comparation of Dice Similarity and Jaccard Coefficience Against Winnowing Algorithm For Similarity Detection of Indonesian Text Documents
Authors: Purwaningrum Santi , Susanto Agus , Prasetya Nur Wachid Adi 
Published: June 2023

Plagiarism is the act of imitating and quoting and even copying or acknowledging other people's work as one's own work. Plagiarism is currently growing rapidly, especially in the world of education. So that plagiarism detection is needed to prevent plagiarism from growing rapidly. In response to this, this paper intends to conduct research that compares the dice similarity and the jaccard coefficient to find the best document similarity value level against the Winnowing algorithm which functions to find the fingerprint value of each document. The test results show that the winnowing algorithm is quite good at using the dice similarity level with the results of an average similarity value of 71.17615% than testing using jaccard coefficient with the resulting value 35,58837%.
Habitual physical activity improves outcomes among patients with myocardial infarction
Authors: Cai Sidong , Huang Fangmei , Wang Run , Wu Min , Liu Mingya , Peng Yufen , Cao Gaozhen , Li Yapin , Liu Shuhong , Lu Jiena , Su Mengqi , Wei Yinxia , Yiu Kai-Hang , Chen Cong 
Published: June 2023

PurposeThis study evaluates the association between habitual physical activity (HPA) and the outcomes of patients with myocardial infarction (MI).MethodsPatients newly diagnosed with MI were divided into two groups based on whether they engaged in HPA, defined as an aerobic activity with a duration of no less than 150 min/week, before the index admission. The primary outcomes included major adverse cardiovascular events (MACEs), cardiovascular (CV) mortality, and cardiac readmission rate 1 year following the index date of admission. A binary logistic regression model was applied to analyze whether HPA was independently associated with 1-year MACEs, 1-year CV mortality, and 1-year cardiac readmission rate.ResultsAmong the 1,266 patients (mean age 63.4 years, 72% male), 571 (45%) engaged in HPA, and 695 (55%) did not engage in HPA before MI. Patients who participated in HPA were independently associated with a lower Killip class upon admission (OR = 0.48: 95% CI, 0.32–0.71, p &lt; 0.001) and a lower prevalence of 1-year MACEs (OR = 0.74: 95% CI, 0.56–0.98, p = 0.038) and 1-year CV mortality (OR = 0.50: 95% CI, 0.28–0.88, p = 0.017) than those who did not participate in HPA. HPA was not associated with cardiac-related readmission (OR = 0.87: 95% CI, 0.64–1.17, p = 0.35).ConclusionsHPA before MI was independently associated with a lower Killip class upon admission, 1-year MACEs, and 1-year CV mortality rate.
Novel compound heterozygous variants of SLC12A3 gene in a Chinese patient with Gitelman syndrome: a case report
Authors: Chen Wenqing , Zhou Qin , Chen Hongjun , Li Heng , Chen Jianghua 
Published: June 2023

Background: The Gitelman syndrome (GS) is an autosomal recessive disorder of renal tubular salt handling. Gitelman syndrome is characterized by hypokalemia, metabolic alkalosis, hypomagnesemia, hypocalciuria, and renin-angiotensin-aldosterone system (RAAS) activation, and is caused by variants in the SLC12A3 gene. Gitelman syndrome has a heterogeneous phenotype, which may or may not include a range of clinical signs, posing certain difficulties for clinical diagnosis.Case presentation: A 49-year-old man was admitted to our hospital due to muscular weakness. The patient’s history revealed previous recurrent muscular weakness events associated with hypokalemia, featured by a minimum serum potassium value of 2.3 mmol/L. The reported male patient had persistent hypokalemia, hypocalciuria and normal blood pressure, without presenting obvious metabolic alkalosis, growth retardation, hypomagnesemia, hypochloremia or RAAS activation. We performed whole-exome sequencing and identified a novel compound heterozygous variant in the SLC12A3 gene, c.965-1_976delGCGGACATTTTTGinsACCGAAAATTTT in exon8 and c.1112T&gt;C in exon9 in the proband.Conclusion: This is a study to report a heterogeneous phenotype Gitelman syndrome with a novel pathogenic compound heterozygous variant in the SLC12A3 gene. This genetic study expands the variants spectrum, and improve the diagnostic accuracy of Gitelman syndrome. Meanwhile, further functional studies are required to investigate the pathophysiological mechanisms of Gitelman syndrome.
Inhibition of γ-glutamyl transferase suppresses airway hyperresponsiveness and airway inflammation in a mouse model of steroid resistant asthma exacerbation
Authors: Zhang Cancan , Xu Huisha , Netto Keilah G. , Sokulsky Leon A. , Miao Yiyan , Mo Zhongyuan , Meng Yan , Du Yingying , Wu Chengyong , Han Liyou , Zhang Lirong , Liu Chi , Zhang Guojun , Li Fuguang , Yang Ming 
Published: June 2023

IntroductionDespite recent advances, there are limited treatments available for acute asthma exacerbations. Here, we investigated the therapeutic potential of GGsTop, a γ-glutamyl transferase inhibitor, on the disease with a murine model of asthma exacerbation.MethodsGGsTop was administered to mice that received lipopolysaccharide (LPS) and ovalbumin (OVA) challenges. Airway hyperresponsiveness (AHR), lung histology, mucus hypersecretion, and collagen deposition were analyzed to evaluate the hallmark features of asthma exacerbation. The level of proinflammatory cytokines and glutathione were determined with/without GGsTop. The transcription profiles were also examined.ResultsGGsTop attenuates hallmark features of the disease with a murine model of LPS and OVA driven asthma exacerbation. Airway hyperresponsiveness (AHR), mucus hypersecretion, collagen deposition, and expression of inflammatory cytokines were dramatically inhibited by GGsTop treatment. Additionally, GGsTop restored the level of glutathione. Using RNA-sequencing and pathway analysis, we demonstrated that the activation of LPS/NFκB signaling pathway in airway was downregulated by GGsTop. Interestingly, further analysis revealed that GGsTop significantly inhibited not only IFNγ responses but also the expression of glucocorticoid-associated molecules, implicating that GGsTop profoundly attenuates inflammatory pathways.ConclusionsOur study suggests that GGsTop is a viable treatment for asthma exacerbation by broadly inhibiting the activation of multiple inflammatory pathways.
Identifying shared genetic loci and common risk genes of rheumatoid arthritis associated with three autoimmune diseases based on large-scale cross-trait genome-wide association studies
Authors: Wen Ya-Ping , Yu Zu-Guo 
Published: June 2023

IntroductionSubstantial links between autoimmune diseases have been shown by an increasing number of studies, and one hypothesis for this comorbidity is that there is a common genetic cause.MethodsIn this paper, a large-scale cross-trait Genome-wide Association Studies (GWAS) was conducted to investigate the genetic overlap among rheumatoid arthritis, multiple sclerosis, inflammatory bowel disease and type 1 diabetes.Results and discussionThrough the local genetic correlation analysis, 2 regions with locally significant genetic associations between rheumatoid arthritis and multiple sclerosis, and 4 regions with locally significant genetic associations between rheumatoid arthritis and type 1 diabetes were discovered. By cross-trait meta-analysis, 58 independent loci associated with rheumatoid arthritis and multiple sclerosis, 86 independent loci associated with rheumatoid arthritis and inflammatory bowel disease, and 107 independent loci associated with rheumatoid arthritis and type 1 diabetes were identified with genome-wide significance. In addition, 82 common risk genes were found through genetic identification. Based on gene set enrichment analysis, it was found that shared genes are enriched in exposed dermal system, calf, musculoskeletal, subcutaneous fat, thyroid and other tissues, and are also significantly enriched in 35 biological pathways. To verify the association between diseases, Mendelian randomized analysis was performed, which shows possible causal associations between rheumatoid arthritis and multiple sclerosis, and between rheumatoid arthritis and type 1 diabetes. The common genetic structure of rheumatoid arthritis, multiple sclerosis, inflammatory bowel disease and type 1 diabetes was explored by these studies, and it is believed that this important discovery will lead to new ideas for clinical treatment.
Coexistence of blaIMP-4, blaNDM-1 and blaOXA-1 in blaKPC-2-producing Citrobacter freundii of clinical origin in China
Authors: Qiao Jie , Chen Yingying , Ge Haoyu , Xu Hao , Guo Xiaobing , Liu Ruishan , Li Chenyu , Chen Ruyan , Gou Jianjun , Chen Mantao , Zheng Beiwen 
Published: June 2023

PurposeTo explore the genetic characteristics of the IMP-4, NDM-1, OXA-1, and KPC-2 co-producing multidrug-resistant (MDR) clinical isolate, Citrobacter freundii wang9.MethodsMALDI-TOF MS was used for species identification. PCR and Sanger sequencing analysis were used to identify resistance genes. In addition to agar dilution, broth microdilution was used for antimicrobial susceptibility testing (AST). We performed whole genome sequencing (WGS) of the strains and analyzed the resulting data for drug resistance genes and plasmids. Phylogenetic trees were constructed with maximum likelihood, plotted using MAGA X, and decorated by iTOL.ResultsCitrobacter freundii carrying blaKPC-2, blaIMP-4, blaOXA-1, and blaNDM-1 are resistant to most antibiotics, intermediate to tigecycline, and only sensitive to polymyxin B, amikacin, and fosfomycin. The blaIMP-4 coexists with the blaNDM-1 and the blaOXA-1 on a novel transferable plasmid variant pwang9-1, located on the integron In1337, transposon TnAS3, and integron In2054, respectively. The gene cassette sequence of integron In1337 is IntI1-blaIMP-4-qacG2-aacA4′-catB3Δ, while the gene cassette sequence of In2054 is IntI1-aacA4cr-blaOXA-1-catB3-arr3-qacEΔ1-sul1. The blaNDM-1 is located on the transposon TnAS3, and its sequence is IS91-sul-ISAba14-aph (3′)-VI-IS30-blaNDM-1-ble-trpF-dsbD-IS91. The blaKPC-2 is located on the transposon Tn2 of plasmid pwang9-1, and its sequence is klcA-korC-ISkpn6-blaKPC-2-ISkpn27-tnpR-tnpA. Phylogenetic analysis showed that most of the 34\u00B0C. freundii isolates from China were divided into three clusters. Among them, wang1 and wang9 belong to the same cluster as two strains of C. freundii from environmental samples from Zhejiang.ConclusionWe found C. freundii carrying blaIMP–4, blaNDM–1, blaOXA-1, and blaKPC-2 for the first time, and conducted in-depth research on its drug resistance mechanism, molecular transfer mechanism and epidemiology. In particular, we found that blaIMP-4, blaOXA-1, and blaNDM-1 coexisted on a new transferable hybrid plasmid that carried many drug resistance genes and insertion sequences. The plasmid may capture more resistance genes, raising our concern about the emergence of new resistance strains.
Halomonas gemina sp. nov. and Halomonas llamarensis sp. nov., two siderophore-producing organisms isolated from high-altitude salars of the Atacama Desert
Authors: Hintersatz Christian , Singh Shalini , Rojas Luis Antonio , Kretzschmar Jerome , Wei Sean Ting-Shyang , Khambhati Khushal , Kutschke Sabine , Lehmann Falk , Singh Vijai , Jain Rohan , Pollmann Katrin 
Published: June 2023

IntroductionThis study aimed to identify and characterize novel siderophore-producing organisms capable of secreting high quantities of the iron-binding compounds. In the course of this, two not yet reported halophilic strains designated ATCHAT and ATCH28T were isolated from hypersaline, alkaline surface waters of Salar de Llamará and Laguna Lejía, respectively. The alkaline environment limits iron bioavailability, suggesting that native organisms produce abundant siderophores to sequester iron.MethodsBoth strains were characterized by polyphasic approach. Comparative analysis of the 16S rRNA gene sequences revealed their affiliation with the genus Halomonas. ATCHAT showed close similarity to Halomonas salicampi and Halomonas vilamensis, while ATCH28T was related closest to Halomonas ventosae and Halomonas salina. The ability of both strains to secrete siderophores was initially assessed using the chromeazurol S (CAS) liquid assay and subsequently further investigated through genomic analysis and NMR. Furthermore, the effect of various media components on the siderophore secretion by strain ATCH28T was explored.ResultsThe CAS assay confirmed the ability of both strains to produce iron-binding compounds. Genomic analysis of strain ATCHAT revealed the presence of a not yet reported NRPS-dependant gene cluster responsible for the secretion of siderophore. However, as only small amounts of siderophore were secreted, further investigations did not lie within the scope of this study. Via NMR and genomic analysis, strain ATCH28T has been determined to produce desferrioxamine E (DFOE). Although this siderophore is common in various terrestrial microorganisms, it has not yet been reported to occur within Halomonas, making strain ATCH28T the first member of the genus to produce a non-amphiphilic siderophore. By means of media optimization, the produced quantity of DFOE could be increased to more than 1000 µM.DiscussionPhenotypic and genotypic characteristics clearly differentiated both strains from other members of the genus Halomonas. Average nucleotide identity (ANI) values and DNA–DNA relatedness indicated that the strains represented two novel species. Therefore, both species should be added as new representatives of the genus Halomonas, for which the designations Halomonas llamarensis sp. nov. (type strain ATCHAT = DSM 114476 = LMG 32709) and Halomonas gemina sp. nov. (type strain ATCH28T = DSM 114418 = LMG 32708) are proposed.