bluuebunny/crossref_metadata_2025_split huggingface dataset:
Voxel-based dosimetry predicting treatment response and related toxicity in HCC patients treated with resin-based Y90 radioembolization: a prospective, single-arm study
Authors: Kokabi Nima , Arndt-Webster Linzi , Chen Bernard , Brandon David , Sethi Ila , Davarpanahfakhr Amir , Galt James , Elsayed Mohammad , Bercu Zachary , Cristescu Mircea , Kappadath S. Cheenu , Schuster David M. 
Published: January 2023

Abstract

Background
There is an increasing body of evidence indicating Y90 dose thresholds for tumor response and treatment-related toxicity. These thresholds are poorly studied in resin Y90, particularly in hepatocellular carcinoma (HCC).

Purpose
To evaluate the efficacy of prospective voxel-based dosimetry for predicting treatment response and adverse events (AEs) in patients with HCC undergoing resin-based Y90 radioembolization.

Materials and methods
This correlative study was based on a prospective single-arm clinical trial (NCT04172714), which evaluated the efficacy of low/scout (555 MBq) activity of resin-based Y90 for treatment planning. Partition model was used with goal of tumor dose (TD) > 200 Gy and non-tumoral liver dose (NTLD) < 70 Gy for non-segmental therapies. Single compartment dose of 200 Gy was used for segmentectomies. Prescribed Y90 activity minus scout activity was administered for therapeutic Y90 followed by Y90-PET/CT. Sureplan® (MIM Software, Cleveland, OH) was used for dosimetry analysis. Treatment response was evaluated at 3 and 6 months. Receiver operating characteristic curve determined TD response threshold for objective response (OR) and complete response (CR) as well as non-tumor liver dose (NTLD) threshold that predicted AEs.

Results
N = 30 patients were treated with 33 tumors (19 segmental and 14 non-segmental). One patient died before the first imaging, and clinical follow-up was excluded from this analysis. Overall, 26 (81%) of the tumors had an OR and 23 (72%) had a CR. A mean TD of 253 Gy predicted an OR with 92% sensitivity and 83% specificity (area under the curve (AUC = 0.929, p < 0.001). A mean TD of 337 Gy predicted a CR with 83% sensitivity and 89% specificity (AUC = 0.845, p < 0.001). A mean NTLD of 81 and 87 Gy predicted grade 3 AEs with 100% sensitivity and 100% specificity in the non-segmental cohort at 3- and 6-month post Y90, respectively.

Conclusion
In patients with HCC undergoing resin-based Y90, there are dose response and dose toxicity thresholds directly affecting outcomes.
Clinical trial number: NCT04172714.
Fur removal promotes an earlier expression of involution-related genes in mammary gland of lactating mice
Authors: Król Elżbieta , Turner Frances , Derous Davina , Mitchell Sharon E. , Martin Samuel A. M. , Douglas Alex , Speakman John R. 
Published: January 2023

AbstractPeak lactation occurs when milk production is at its highest. The factors limiting peak lactation performance have been subject of intense debate. Milk production at peak lactation appears limited by the capacity of lactating females to dissipate body heat generated as a by-product of processing food and producing milk. As a result, manipulations that enhance capacity to dissipate body heat (such as fur removal) increase peak milk production. We investigated the potential correlates of shaving-induced increases in peak milk production in laboratory mice. By transcriptomic profiling of the mammary gland, we searched for the mechanisms underlying experimentally increased milk production and its consequences for mother–young conflict over weaning, manifested by advanced or delayed involution of mammary gland. We demonstrated that shaving-induced increases in milk production were paradoxically linked to reduced expression of some milk synthesis-related genes. Moreover, the mammary glands of shaved mice had a gene expression profile indicative of earlier involution relative to unshaved mice. Once provided with enhanced capacity to dissipate body heat, shaved mice were likely to rear their young to independence faster than unshaved mothers.
Gracilis muscle transposition in complex anorectal fistulas of diverse types and etiologies: long-term results of 60 cases
Authors: Schoene Milla Isabelle , Schatz Sabine , Brunner Marion , Fuerst Alois 
Published: January 2023

Abstract
Purpose
Complex fistulas often require several attempts at repair and continue to be a challenging task for the surgeon, but above all, a major burden for the affected patient. This study is aimed at evaluating the potential of gracilis muscle transposition (GMT) as a therapeutic option for complex fistulas of diverse etiologies.

Methods
A retrospective study was conducted over a period of 16 years with a total of 60 patients (mean age 50 years). All were treated for complex fistula with GMT at St. Josef’s Hospital in Regensburg, Germany. Follow-up data were collected and analyzed using a prospective database and telephone interview. Success was defined as the absence of fistula.

Results
A total of 60 patients (44 women, 16 men; mean age 50 years, range 24–82 years) were reviewed from January 2005 to June 2021. Primary fistula closure after GMT was achieved in 20 patients (33%) and 19 required further interventions for final healing. Overall healing rate was 65%. Fistula type was heterogeneous, with a dominant subgroup of 35 rectovaginal fistulas. Etiologies of the fistulas were irradiation, abscesses, obstetric injury, and iatrogenic/unknown, and 98% of patients had had previous unsuccessful repair attempts (mean 3.6, range 1–15). In 60% of patients with a stoma (all patients had a stoma, 60/60), stoma closure could be performed after successful fistula closure. Mean follow-up after surgery was 35.9 months (range 1–187 months). No severe intraoperative complications occurred. Postoperative complications were observed in 25%: wound healing disorders (n = 6), gracilis necroses (n = 3), incisional hernia (n = 2), scar tissue pain (n = 2), suture granuloma (n = 1), and osteomyelitis (n = 1). In 3 patients, a second gracilis transposition was performed due to fistula recurrence (n = 2) or fecal incontinence (n = 1).

Conclusion
Based on the authors’ experience, GMT is an effective therapeutic option for the treatment of complex fistulas when other therapeutic attempts have failed and should therefore be considered earlier in the treatment process. It should be seen as the main but not the only step, as additional procedures may be required for complete closure in some cases.
Co-cultivation of human granulosa cells with ovarian cancer cells leads to a significant increase in progesterone production
Authors: Pietrowski Detlef , Grgic Martina , Haslinger Isabella , Marschalek Julian , Schneeberger Christian 
Published: January 2023

Abstract
Purpose
In humans, granulosa cells (GCs) are part of the follicle and nourish the growing oocyte. GCs produce estrogen and, after ovulation, progesterone. They are embedded in a multicellular tissue structure of the ovary, which consists of a variety of different cell types that are essential for the physiological function of the ovary. However, the extent to which individual ovarian cell types contribute to overall functionality has not yet been fully elucidated. In this study, we aim to investigate the effects of co-culturing human granulosa cells with ovarian cancer cells on their progesterone and estrogen production in an in vitro model.

Methods
After seeding, the cells were stimulated with 200 µM forskolin in DMEM for 72 h and the medium of the different cell culture experiments was collected. Subsequently, progesterone and oestradiol concentrations were determined using an Elisa assay.

Results
Morphologically, it was striking that the cells self-organize and form spatially separated areas. Compared to culturing granulosa cells alone, co-culturing human granulosa cells together with the ovarian cancer cell line OvCar-3 resulted in a significant increase in progesterone production (20.3 ng/ml versus 50.2 ng/ml; p < 0.01).

Conclusions
Using a simple in vitro model, we highlight the importance of cellular crosstalk between different ovarian cells in a complex cellular network and that it strongly influences granulosa cell hormone production. This could have potential implications for the procedure of transplanting endocrine tissues after cryopreservation, as it highlights the importance of survival of all cells for the functionality of the transplanted tissue.
Phase 1b study of intravenous coxsackievirus A21 (V937) and ipilimumab for patients with metastatic uveal melanoma
Authors: Lutzky Jose , Sullivan Ryan J. , Cohen Justine V. , Ren Yixin , Li Anlong , Haq Rizwan 
Published: January 2023

Abstract
Purpose
No standard of care therapy exists for patients with metastatic uveal melanoma who are not HLA-A2:01 positive. The phase 1b, open-label CLEVER study (NCT03408587) evaluated V937 in combination with ipilimumab in patients with uveal melanoma.

Methods
Adults with advanced uveal melanoma and liver metastases received up to 8 cycles of intravenous V937 (1 × 109 TCID50 per infusion; infusions on days 1, 3, 5, and 8 [cycle 1], then every 3 weeks [Q3W] thereafter [cycles 2–8]) and 4 cycles of intravenous ipilimumab 3 mg/kg Q3W (beginning at cycle 1 day 8). The primary endpoint was safety. Secondary endpoints included objective response rate and progression-free survival (PFS) per immune-related Response Evaluation Criteria in Solid Tumors (irRECIST).

Results
Eleven patients were enrolled (median age, 65.0 years) and received a median of 6 injections of V937 and 3.5 infusions of ipilimumab. The best overall response was stable disease in 3 patients and progressive disease in 8 patients. All patients exhibited progression per irRECIST, with a 9% irPFS rate at week 26. Ten patients had treatment-related AEs, the most frequent of which were diarrhea (55%), fatigue (45%), and myalgia (36%). Two grade 3 AEs (diarrhea, n = 2) were considered related to ipilimumab; neither was related to V937.

Conclusion
Although the combination of V937 with ipilimumab had a manageable safety profile, meaningful clinical benefit was not observed in patients with uveal melanoma and liver metastases.

Trial registration
ClinicalTrials.gov, NCT03408587 (January 24, 2018).
Evolution of Alkaline Mine Drainage and Unique Biodiversity on Soil-Free Mine Substrates, Southern New Zealand
Authors: Craw Dave , Rufaut Cathy , Pillai Dhana 
Published: January 2023

AbstractRelatively impermeable soil-free substrates (clay-rich outcrops and sediments) exposed at eight abandoned placer gold mines generate alkaline mine drainage through evaporation and minor interaction between water and rock in a semi-arid rain shadow climate. Original mine sluicing a century ago created drainage channels over the land surface that still control the flow of ephemeral surface waters, with localised construction of erosional outwash pans. Ephemeral surface waters and associated evaporitic salts are dominated by halite derived from marine aerosols in rain, yielding circumneutral pH and electrical conductivity (EC) values locally exceeding 50 mS/cm. Weakly altered schist basement rocks and Miocene mudstone exposed at the surface contain abundant calcite, and surface waters are supersaturated with respect to Ca-carbonate minerals with a pH of ≈ 8 and an EC of ≈ 1 mS/cm. Water interaction with albite increases the dissolved Na/Cl molar ratio to > 1, and evaporative formation of Na-carbonate precipitates can raise the pH to > 10. Pyrite oxidation does not offset the alkaline pH in any of these processes, although dissolved sulfate can rise to high levels (> 2000 mg/L; EC ≈ 5 mS/cm), forming evaporative sulfate minerals. Ephemeral waters drain down outcrops and the relatively impermeable erosional pans, leaving salt encrustations with variable mineralogy and associated waters with pH and EC values that are partially controlled by rates of dissolution and reprecipitation of the minerals in the salts. The saline alkaline chemistry of the pans excludes most vegetation and has allowed development of salt-tolerant ecosystems with rare endemic halophytic plants. Maintenance of soil-free halophytic surfaces has potential applications in dryland mine sites around the world, especially as climate change enhances and extends aridity.
Spring phenology is advancing at a faster rate than arrival times of Common Starling
Authors: Dinsbergs Ivo , Keišs Oskars , Briedis Martins 
Published: January 2023

AbstractClimate change poses significant impact on most migratory species, altering their breeding and non-breeding distributions, migration distances, and phenology. The ability of a population to track and adjust to the changing environmental conditions is a vital prerequisite for its persistence. In this study, we describe changes in spring arrival phenology of a short-distance migrant, the Common StarlingSturnus vulgaris, in Northeastern Europe and their relation to changes in the onset of meteorological spring during the last century. Phenological data were obtained from an open access databaseChronicles of Nature Calendarthat held 4291 usable records of the 1st spring observation date of Starlings from 171 phenological network sites between 1922 and 2017. Air temperature data were downloaded from the European Climate Assessment and Dataset database. We found that spring arrival time of Starlings was positively correlated with the onset of spring on a local and broad scale. Spring arrival progression followed a northeast gradient at an average rate of 1.6 days per one degree of latitude (ca. 71 km day−1) and 0.4 days per one degree of longitude (152 km day−1). During the 96-year long period, Starlings on average advanced their spring arrival time by 4.7 days at a rate of 0.05 days per year. However, changes in the onset of spring occurred more rapidly with an average rate of change of 0.18 days per year over the study period. These findings imply broad-scale adjustments in migratory patterns of a short-distance migrant that result from climate change-induced shifts in spring phenology. However, adaptations in bird migration phenology are not occurring fast enough to track and compensate for the rapid increase in air temperature, thus disrupting the earlier matching between bird arrival and spring onset.
Effects of a 7-Day Pornography Abstinence Period on Withdrawal-Related Symptoms in Regular Pornography Users: A Randomized Controlled Study
Authors: Fernandez David P. , Kuss Daria J. , Justice Lucy V. , Fernandez Elaine F. , Griffiths Mark D. 
Published: January 2023

AbstractLittle is known about whether withdrawal-like symptoms manifest when regular pornography users attempt to abstain from pornography. The present study used a randomized controlled design to examine whether (1) negative abstinence effects that may be potentially reflective of withdrawal-related symptoms manifest when a non-clinical sample of regular pornography users attempt to abstain from pornography for a 7-day period and (2) these negative abstinence effects would only manifest (or manifest more strongly) for those with higher levels of problematic pornography use (PPU). A total of 176 undergraduate students (64.2% female) who were regular pornography users (defined as having used pornography ≥ three times a week in the past 4 weeks) were randomly assigned to an abstinence group (instructed to attempt abstinence from pornography for 7 days, n = 86) or a control group (free to watch pornography as usual, n = 90). Participants completed measures of craving, positive and negative affect, and withdrawal symptoms at baseline and each night of the 7-day period. Contrary to the confirmatory hypotheses, there were no significant main effects of group (abstinence vs. control) or group × PPU interaction effects on any of the outcome measures, controlling for baseline scores. These findings indicate that no evidence of withdrawal-related symptoms was found for abstaining participants, and this was not dependent on level of PPU. However, exploratory analyses showed a significant three-way interaction (group × PPU × past 4-week frequency of pornography use [FPU]) on craving, where an abstinence effect on craving was found at high levels of PPU only once past 4-week FPU reached the threshold of daily use. While these exploratory findings should be interpreted with caution, they suggest that abstinence effects could potentially manifest when there is a combination of high PPU and high FPU—a hypothesis that warrants investigation in future prospective abstinence studies.
The naturalized vascular flora of Malesia
Authors: Holmes Rachael , Pelser Pieter , Barcelona Julie , Tjitrosoedirdjo Sri Sudarmiyati , Wahyuni Indah , van Kleunen Mark , Pyšek Petr , Essl Franz , Kreft Holger , Dawson Wayne , Wijedasa Lahiru , Kortz Alessandra , Hejda Martin , Berrio Juan Carlos , Siregar Iskandar , Williams Mark 
Published: January 2023

AbstractMajor regional gaps exist in the reporting and accessibility of naturalized plant species distribution data, especially within Southeast Asia. Here, we present the Malesian Naturalized Alien Flora database (MalNAF), the first standardized island-group level checklist of naturalized vascular plant species for the Malesian phytogeographical region. We used MalNAF to investigate the composition, origins, and habitat preferences of the naturalized flora. The naturalized vascular flora of Malesia consists of at least 1177 species. Richness is highest in the Philippines (539 spp.) and lowest in the Maluku Islands (87 spp.). But, the Lesser Sunda Islands had the highest naturalized species richness relative to native richness and Singapore has a higher naturalized plant species richness than would be expected given its size. When comparing the data for Malesia with a global dataset, we found that naturalized richness increased with area for islands but not for continental regions. Across the archipelago, 31 species are widespread, occurring in every island group, but the majority have a limited distribution of 2.4 ± 2.3 (mean ± SD) island groups per naturalized species. The naturalized plant species are representatives of 150 families, twenty of which are newly introduced to the region. Families richest in naturalized plant species in Malesia were Fabaceae (= Leguminosae) (160 spp.), Poaceae (= Gramineae) (138 spp.), and Asteraceae (= Compositae) (96 spp.). Most of these have a native range that includes tropical Asia, closely followed by those from Southern America (inclusive of the Caribbean, Central and South America), although at the island-group level, most have a higher proportion with a Southern American native range. Most naturalized species occur in anthropogenic habitats, but many are present in “natural” habitats with fewer species, such as Leucaena leucocephala, reported from specialized habitats like drylands. MalNAF provides a baseline for future studies of naturalized plant species distributions in the region.
Mechanics of an Iron Ore Tailings Exhibiting Transitional Behaviour
Authors: Mmbando Erwin , Fourie Andy , Reid David 
Published: January 2023

AbstractLaboratory critical state line (CSL) testing used in engineering practice to analyse the stability and liquefaction susceptibility of tailings explicitly assumes a unique CSL for a particular tailings. However, there is evidence of non-unique CSLs in some soils, a behaviour commonly referred to as “transitional behaviour”. There is currently limited consensus or understanding of its applicability, what factors contribute to its occurrence, and whether there is a fundamental divergence from critical state theory or an artefact of the strain limitations of laboratory element tests. In this research, normally consolidated samples of an iron ore tailings prepared using the moist tamping and slurry deposition methods were sheared to critical state in triaxial compression tests. The results of these tests showed that a different CSL was apparent for the two specimen preparation methods used. This further emphasises the need to re-evaluate the effects of fabric on the uniqueness of the CSL, which may be a consequence of different sample preparation methods typically used to prepare laboratory element tests.
Effectiveness of mobile telemonitoring applications in heart failure patients: systematic review of literature and meta-analysis
Authors: Rebolledo Del Toro Martín , Herrera Leaño Nancy M. , Barahona-Correa Julián E. , Muñoz Velandia Oscar M. , Fernández Ávila Daniel G. , García Peña Ángel A. 
Published: January 2023

Abstract
Close and frequent follow-up of heart failure (HF) patients improves clinical outcomes. Mobile telemonitoring applications are advantageous alternatives due to their wide availability, portability, low cost, computing power, and interconnectivity. This study aims to evaluate the impact of telemonitoring apps on mortality, hospitalization, and quality of life (QoL) in HF patients. We conducted a registered (PROSPERO CRD42022299516) systematic review of randomized clinical trials (RCTs) evaluating mobile-based telemonitoring strategies in patients with HF, published between January 2000 and December 2021 in 4 databases (PubMed, EMBASE, BVSalud/LILACS, Cochrane Reviews). We assessed the risk of bias using the RoB2 tool. The outcome of interest was the effect on mortality, hospitalization risk, and/or QoL. We performed meta-analysis when appropriate; heterogeneity and risk of publication bias were evaluated. Otherwise, descriptive analyses are offered. We screened 900 references and 19 RCTs were included for review. The risk of bias for mortality and hospitalization was mostly low, whereas for QoL was high. We observed a reduced risk of hospitalization due to HF with the use of mobile-based telemonitoring strategies (RR 0.77 [0.67; 0.89]; I2 7%). Non-statistically significant reduction in mortality risk was observed. The impact on QoL was variable between studies, with different scores and reporting measures used, thus limiting data pooling. The use of mobile-based telemonitoring strategies in patients with HF reduces risk of hospitalization due to HF. As smartphones and wirelessly connected devices are increasingly available, further research on this topic is warranted, particularly in the foundational therapy.
Travelling Waves in a PDE–ODE Coupled Model of Cellulolytic Biofilms with Nonlinear Diffusion
Authors: Mitra K. , Hughes J. M. , Sonner S. , Eberl H. J. , Dockery J. D. 
Published: January 2023

AbstractWe analyze travelling wave (TW) solutions for nonlinear systems consisting of an ODE coupled to a degenerate PDE with a diffusion coefficient that vanishes as the solution tends to zero and blows up as it approaches its maximum value. Stable TW solutions for such systems have previously been observed numerically as well as in biological experiments on the growth of cellulolytic biofilms. In this work, we provide an analytical justification for these observations and prove existence and stability results for TW solutions of such models. Using the TW ansatz and a first integral, the system is reduced to an autonomous dynamical system with two unknowns. Analysing the system in the corresponding phase–plane, the existence of a unique TW is shown, which possesses a sharp front and a diffusive tail, and is moving with a constant speed. The linear stability of the TW in two space dimensions is proven under suitable assumptions on the initial data. Finally, numerical simulations are presented that affirm the theoretical predictions on the existence, stability, and parametric dependence of the travelling waves.