bluuebunny/crossref_metadata_2025_split huggingface dataset:
A real‐world study to assess the association of cardiovascular adverse events (CVAEs) with ibrutinib as first‐line (1L) treatment for patients with chronic lymphocytic leukaemia (CLL) in the United States
Authors: Mato Anthony , Tang Boxiong , Azmi Soraya , Yang Keri , Han Yi , Zhang Xiaowei , Roeker Lindsey , Wallis Nicola , Stern Jennifer C. , Hedrick Eric , Huang Jane , Sharman Jeff P. 
Published: January 2023

AbstractIbrutinib, a Bruton's tyrosine kinase inhibitor, is often used as first‐line (1L) treatment of chronic lymphocytic leukaemia (CLL); however, it is associated with an increased risk for cardiovascular adverse events (CVAEs). This real‐world study adds to existing literature by simultaneously investigating the correlation between pre‐existing CV risk factors and the relative cardiotoxicity of ibrutinib vs other therapies in CLL/small lymphocytic lymphoma (SLL). Using a real‐world database, the risk of subsequent CVAEs (any CVAE, atrial fibrillation [AF], or hypertension) were compared among patients who received 1L ibrutinib monotherapy or another type of non‐ibrutinib therapy, grouped as intensive (IT) or non‐intensive therapy (NIT). Each patient's baseline CV risk was estimated using the Framingham risk score. Inverse probability treatment weighting was incorporated into a logistic regression model to reduce baseline imbalance. Results showed ibrutinib was significantly associated with higher risk of CVAEs regardless of baseline CV risk. Compared with IT, odds ratios of any CVAE, hypertension, or AF were 2.61, 3.66, and 3.02, respectively vs 1.88, 2.13, and 2.46, respectively, with NIT. Sensitivity analyses confirmed the findings were robust. These results suggest clinical caution should be taken when selecting ibrutinib for patients with CLL/SLL, especially in those with high baseline CV risk.
Organization of the body wall in lampreys informs the evolution of the vertebrate paired appendages
Authors: Onai Takayuki 
Published: January 2023

AbstractVertebrate paired appendages are one of the most important evolutionary novelties in vertebrates. During embryogenesis, the skeletal elements of paired appendages differentiate from the somatic mesoderm, which is a layer of lateral plate mesoderm. However, the presence of the somatic mesoderm in the common ancestor of vertebrates has been controversial. To address this problem, it is necessary but insufficient to understand the developmental process of lateral plate mesoderm formation in lamprey (jawless vertebrates) embryos. Here, I show the presence of the somatic mesoderm in lamprey (Lethenteron camtschaticum) embryos using plastic sectioning and transmission electron microscopy analysis. During the early pharyngeal stages, the somatic mesoderm transforms from the lateral plate mesoderm in the trunk region. Soon after, when the cardiac structures were morphologically distinct, the somatic mesoderm was recognized through the cardiac to more caudal regions. These findings indicated that the somatic mesoderm evolved before the emergence of paired appendages. I also discuss the developmental changes in the body wall organization in the common ancestor of vertebrates, which is likely related to the evolution of the paired appendages.
An Integrated Algorithm for Differentiating Hypertrophic Cardiomyopathy From Hypertensive Heart Disease
Authors: Kong Ling‐cong , Wu Lian‐ming , Wang Zi , Liu Chang , He Ben 
Published: January 2023

BackgroundDifferentiating hypertrophic cardiomyopathy (HCM) from hypertensive heart disease (HHD) is challenging.PurposeTo identify differences between HCM and HHD on a patient basis using MRI.Study TypeRetrospective.PopulationA total of 219 subjects, 148 in phase I (baseline data and algorithm development: 75 HCM, 33 HHD, and 40 controls) and 71 in phase II (algorithm validation: 56 HCM and 15 HHD).Field Strength/SequenceContrast‐enhanced inversion‐prepared gradient echo and cine‐balanced steady‐state free precession sequences at 3.0 T.AssessmentMRI parameters assessed included left ventricular (LV) ejection fraction (LVEF), LV end systolic and end diastolic volumes (LVESV and LVEDV), mean maximum LV wall thickness (MLVWT), LV global longitudinal and circumferential strain (GRS, GLS, and GCS), and native T1. Parameters, which were significantly different between HCM and HHD in univariable analysis, were entered into a principal component analysis (PCA). The selected components were then introduced into a multivariable regression analysis to model an integrated algorithm (IntA) for screening the two disorders. IntA performance was assessed for patients with and without LGE in phase I (development) and phase II (validation).Statistical TestsUnivariable regression, PCA, receiver operating curve (ROC) analysis. A P value <0.05 was considered statistically significant.ResultsDerived IntA formulation included LVEF, LVESV, LVEDV, MLVWT, and GCS. In LGE‐positive subjects in phase l, the cutoff point of IntA ≥81 indicated HCM (83% sensitivity and 91% specificity), with the area under the ROC curve (AUC) of 0.900. In LGE‐negative subjects, a higher possibility of HCM was indicated by a cutoff point of IntA ≥84 (100% sensitivity and 82% specificity), with an AUC of 0.947. Validation of IntA in phase II resulted in an AUC of 0.846 in LGE‐negative subjects and 0.857 in LGE‐positive subjects.Data ConclusionA per‐patient‐based IntA algorithm for differentiating HCM and HHD was generated from MRI data and incorporated FT, LGE and morphologic parameters.Evidence Level3.Technical EfficacyStage 2.
Nano‐scale design of full adder and full subtractor using reversible logic based decoder circuit in quantum‐dot cellular automata
Authors: Das Jadav Chandra , De Debashis 
Published: January 2023

AbstractThis paper presents a reversible nano‐scale decoder circuit. The decoder is designed by utilizing the new quantum‐dot cellular automata (QCA) format of the QCA1 gate. This QCA1 gate provides 34.25% less cell count with 54.37% less area than the best existing designs. Thus, the proposed QCA1 gate provides less area considering the best existing state‐of‐the‐art plans. The IBMQ‐based quantum realization of the QCA1 gate is also illustrated. The reversible full adder and subtractor circuits by employing the proposed decoder are likewise explored in this paper. A four‐input reversible OR‐gate is structured and concatenates with a decoder circuit to frame the circuit for full adder and subtractor. The energy dissipation by these QCA circuits is assessed to build up that QCA is an attractive option to CMOS for realizing reversible logic designs. The implemented results are compared with the truth table to ensure operational accuracy. The planned circuits can be utilized to structure reversible designs for nano‐communication.
Impact of the interannual variability of the South China Sea monsoon trough on tropical cyclone activity over the western North Pacific
Authors: Zhang Zeyu , Jian Maoqiu , Gao Si 
Published: January 2023

AbstractThe present study reveals the impact of the interannual variability of the South China Sea monsoon trough (SCSMT) on tropical cyclone (TC) activity over the South China Sea (SCS) and the western North Pacific (WNP) from June to August during the period of 1958–2019. The SCSMT can influence TC genesis and occurrence through affecting the large‐scale environmental conditions and barotropic energy conversion. The intensification of the SCSMT can lead to enhanced low‐level vorticity and upper‐level divergence, decreased vertical wind shear, and increased midlevel humidity over the northern SCS and subtropical WNP. The strengthening of the SCSMT is accompanied by an intensification and eastward extension of the WNP monsoon trough and eastward retreat of the WNP subtropical high. All these changes associated with the SCSMT are favourable for TC genesis and occurrence over the north SCS and WNP. More TCs form over the WNP around 20° N, while higher TC occurrence frequency appears over the north SCS and WNP north of 20° N. Diagnostic results of eddy kinetic energy distribution and barotropic energy conversion provide a possible explanation for the impact of the SCSMT on TC activity. The synoptic‐scale disturbances are more active in the WNP region north of 20° N which might lead to an increase in TC occurrence frequency. While the barotropic energy conversion is intensified in the northern SCS and east of Philippines, more eddy energy converted from the mean flow is favourable for TC genesis. The meridional shear of mean zonal wind and the meridional convergence of mean meridional wind, which are related with the interannual variability of the SCSMT, primarily contribute to the barotropic energy conversion.
Relationship between circulating senescence‐associated secretory phenotype levels and severity of type 2 diabetes‐associated periodontitis: A cross‐sectional study
Authors: Song Xiuxiu , Yue Ziqi , Fan Linli , Zou Haonan , Zhao Pengfei , Nie Lulingxiao , Zhu Kangjian , Jiang Jingjing , Lv Qingguo , Wang Qi 
Published: January 2023

AbstractBackgroundSenescence‐associated secretory phenotype (SASP) has recently been found to drive comorbid diabetes and periodontitis by inducing a chronic, low‐degree inflammatory state. Here, we sought to explore the relationship between circulating SASP and the severity of type 2 diabetes‐associated periodontitis (DP).MethodsEighty patients (middle‐aged periodontitis, M‐P group; aged periodontitis, A‐P group; M‐DP group; and A‐DP group; n = 20) provided gingival epithelium, serum, and periodontal clinical parameters. Circulating levels of 12 DP‐related SASP factors were analyzed by immunoassay. Correlation between periodontal clinical parameters and circulating SASP levels was analyzed by Spearman's rank correlation coefficient and back propagation artificial neural network (BPNN). Senescence markers (p16, p21, and HMGB1) in gingiva were determined by immunofluorescence assay.ResultsM‐DP group had increased serum levels of twelve SASP factors compared with the M‐P group (p < 0.5). Serum levels of IL‐6, IL‐4, and RAGE were higher in the A‐DP group than the A‐P group (p < 0.5). The circulating concentrations of certain SASP proteins, including IL‐1β, IL‐4, MMP‐8, OPG, RANKL, and RAGE were correlated with the clinical parameters of DP. BPNN showed that serum SASP levels had considerable predictive value for CAL of DP. Additionally, the DP group had higher expressions of p16, p21, and cytoplasmic‐HMGB1 in the gingiva than the P group (p < 0.5).ConclusionsSignificantly enhanced circulating SASP levels and aggravated periodontal destruction were observed in patients with DP. Importantly, a non‐negligible association between serum SASP levels and the severity of DP was found.
Deglaciation and postglacial evolution of the Cère Valley (Cantal, French Massif Central) based on geomorphological mapping, 36Cl surface exposure dating and glacier modelling
Authors: Ancrenaz Arthur , Pochat Stéphane , Rinterknecht Vincent , Rodríguez‐Rodríguez Laura , Defive Emmanuelle , Poiraud Alexandre , Jomelli Vincent , Schimmelpfennig Irene , Team Aster 
Published: January 2023

ABSTRACTThe landform assemblage in the Cère Valley (Cantal, France) provides one of the most complete sequences for Late Pleistocene glacial fluctuations in the French Massif Central. However, the associated glacial chronology has been debated since the 1980s. This paper aims to improve the glacial chronology of the Cère Valley using 36Cl surface exposure ages. Geomorphological results define two glacier stadials with reconstructed equilibrium line altitudes of 1078 ± 43 and 1152 ± 34 m above sea level. These results are comparable to those obtained in the Alps or the Pyrenees during the Last Glacial Maximum (26–19.5 ka). However, 36Cl surface exposure ages are centred around the Younger Dryas (YD), between 13 and 11 ka (n = 4). We suggest that these 36Cl ages are not related to a standstill during the YD but rather to the effects of the postglacial evolution of the Cère Valley. We investigate two geomorphological end‐member scenarios to explain the postponed exposure of sampled boulders: the Aurillac Lake scenario and the later fluvial incision scenario. While the nature of the geomorphological events leading to the boulder exhumation is not fully resolved, we highlight a long phase of postglacial evolution in the Cère Valley.
Application of magnetic nanoparticles as demulsifiers for surfactant‐enhanced oil recovery
Authors: Zhang Leilei , Bai Chutian , Zhang Zhuqing , Wang Xinglin , Nguyen Thao Vy , Vavra Eric , Puerto Maura , Hirasaki George J. , Biswal Sibani Lisa 
Published: January 2023

AbstractNonionic surfactants are increasingly being applied in oil recovery processes due to their stability and low adsorption onto mineral surfaces. However, these surfactants lead to the production of emulsified oil that is extremely stable and difficult to separate by conventional methods. This research characterizes the stability of crude oil mixed with a nonionic surfactant, L24–22, in a brine solution. When subjected to gravity separation, a middle oil‐rich and bottom water‐rich emulsion are generated for various water–oil ratios. Thermal treatments can effectively break oil‐rich emulsions, but the bottom water layer remains contaminated with micron‐sized crude oil droplets. A magnetic nanoparticle treatment is shown to demulsify the crude oil emulsions, dropping the total organic carbon (TOC) in the water layer from 1470 to 30 ppm.
Determining functional outcomes after resection and reconstruction of primary soft tissue sarcoma in the lower extremity: A review of current subjective and objective measurement systems
Authors: Wiffen James , Mah Eldon 
Published: January 2023

AbstractThe surgical management of soft‐tissue sarcoma has evolved significantly over the last two decades due to the routine use of adjunct therapies, with an increased focus on postoperative functional outcome. The literature suffers from methodological inconsistency and use of low quality outcome measures to assess an already heterogeneous population. This article aims to review the most frequently used subjective and objective methods of functional outcome assessment and highlight the current benefits and limitations of these.
Mediators of physical activity outcomes in a peer‐led intervention for breast cancer survivors
Authors: Pinto Bernardine M. , Dunsiger Shira I. , DeScenza Victoria R. , Stein Kevin 
Published: January 2023

AbstractObjectivesPhysical activity (PA) adoption can reduce treatment‐related sequelae of breast cancer. Peer‐led PA interventions are a promising and relatively inexpensive approach to scaling up interventions. The current study seeks to identify mediators of PA change amongst cancer survivors enrolled in a peer‐led behavior change intervention. The study team partnered with the American Cancer Society's Reach to Recovery program (RTR) whose volunteers' provided information and support to breast cancer survivors.MethodsParticipants were 76 survivors (mean age 55.6 years, 1.1 years since diagnosis) who were randomized to PA Plus RTR (12‐week PA telephone counseling delivered by RTR volunteers) or contact control. Data was collected on PA (self‐reported and objectively measured) and potential mediators (self‐efficacy, exercise decisional balance [ratio of the pros/advantages to the cons/disadvantages] and social support) at baseline and 12 weeks. Using a multiple mediation approach with bootstrapped standard errors, we examined mediators of the intervention effect on PA outcomes.ResultsCompared to control, PA Plus RTR participants had higher mean self‐efficacy, lower decisional balance cons and social support at 12 weeks controlling for baseline. Higher mean self‐efficacy was associated with greater minutes of self‐reported PA, whereas higher decisional balance pros was associated with higher objectively measured PA at 12 weeks. There were significant indirect effects of self‐efficacy on self‐reported PA and decisional balance on objectively measured PA.ConclusionsPA Plus RTR increased self‐reported and objectively measured PA by changing theoretical constructs hypothesized to be associated with behavior change. Peers delivering a PA intervention should focus on increasing survivors' self‐efficacy for exercise especially in challenging circumstances such as being on vacation, and also help to overcome disadvantages of exercise such as taking time away from family.
Clinical change 2 years from start of elexacaftor‐tezacaftor‐ivacaftor in severe cystic fibrosis
Authors: McCoy Karen S. , Blind Jill , Johnson Terri , Olson Patti , Raterman Laura , Bai Shasha , Eisner Mariah , Sheikh Shahid I. , Druhan Stephan , Young Cody , Pasley Kimberly 
Published: January 2023

AbstractRationaleLimited published research is available on the impact of elexacaftor/tezacaftor/ivacaftor (ETI) beyond the initial few months postdrug initiation, especially for those who initiated therapy via individual investigational new drug application. The experiences of patients with cystic fibrosis (CF) experiencing severe lung disease were reviewed for significant improvements in clinical symptoms and quality of life.ObjectivesTo examine clinical outcomes 2 years post‐ETI in patients with CF and advanced lung disease.MethodsThis single center institutional review board‐approved, retrospective chart review assessed clinical markers (percent predicted forced expiratory volume in 1 s, weight, sweat chloride), quality of life and computed tomography scans in patients with advanced lung disease who met criteria for compassionate use/expanded access program due to high risk of death or transplant need within 2 years.ResultsEighteen identified patients (ages 15−49 years) initiated drug between July and September 2019. Clinical markers indicated that therapy was well tolerated, not discontinued by any participant, and lab values did not indicate medical concern or discontinuation. Monitoring results indicated the safety of modulator therapy as there were no adverse clinical occurrences and all patients presented universal stabilization. There were no deaths and no transplants by the end of the study.ConclusionsThis study focused on patients with CF eligible for modulator therapy and were initiated due to advanced lung disease. Initiation of modulator therapy was deemed safe and resulted in objective positive changes in nutrition, cough, FEV1, subjective reports of clinical status, level of activity, and a reduction in burden of treatment.
The implications of airway anomalies on children with congenital heart disease and bronchiolitis
Authors: Wang Po‐Yuan , Tseng Wei‐Chieh , Wu En‐Ting , Lu Frank Leigh , Chen Shyh‐Jye , Chiu Shuenn‐Nan , Wu Mei‐Hwan , Wang Jou‐Kou , Wang Ching‐Chia 
Published: January 2023

AbstractBackgroundBronchiolitis is a common airway infection in young children. Hemodynamically significant congenital heart disease (CHD) predicts a more complicated course. However, the role of airway anomalies remains unknown.MethodsWe retrospectively reviewed the records of patients under 2 years old, diagnosed with CHD, and admitted between January 2011 and December 2013, before the palivizumab era. Records of bronchiolitis admissions were also extracted. Patients were grouped according to CHD condition and airway anomalies.ResultsA total of 230 patients with CHD were enrolled. A total of 180 (78%) and 71 (31%) patients had hemodynamically significant CHD and airway anomalies, respectively. A total of 52 (22.6%) patients were admitted for bronchiolitis 78 times. Among them, 33 (63.5%) had hemodynamically significant CHD, and 28 (53.8%) had airway anomalies. In patients with bronchiolitis admissions, the mean ventilator use, intensive care unit stay, and hospital stay were 1.08, 4.08, and 15.19 days, respectively. When compared, the mean hospital stay for bronchiolitis patients with airway anomalies was significantly longer than that of those without airway anomalies (19.8 vs. 9.9 days, p = 0.008). When further divided the patients by the presence hemodynamic significance, patients with hemodynamically significant CHD and airway anomaly had longer hospital stay than those who had neither. (21.7 vs. 8.3 days, p = 0.004) Airway anomaly was a significant risk factor for longer hospital stay in linear regression model (p = 0.007).ConclusionsAirway anomalies are common in children with CHD and are associated with longer hospital stays on bronchiolitis admission. An active survey for airway anomalies and adequate prophylaxis for bronchiolitis infection might be important in the care of children with CHD associated with airway anomalies.
Press, pulse, and perceptions: How does media attention signal perceptions about environmental crises?
Authors: Olivier Tomás , Bell Emily V. , García Asorey Martín I. , Rodas‐Gaiter Alejandra 
Published: January 2023

AbstractAt what point do environmental phenomena become crises, and how do these impact the quantity and quality of media attention? As climate patterns change, societies face crises that are slow‐moving in nature (such as sea level rise and drought) or fast‐changing (such as hurricanes or flash floods). A third type of event is those that are slow‐occurring while at the same time being punctuated by extreme, fast‐changing occurrences. The practical and theoretical consequences of these complex events are often difficult to pinpoint. We argue that it is necessary to evaluate how the features of such events affect stakeholder perceptions. We do so by analyzing water‐quality crises in Northeastern Patagonia, Argentina. Combining turbidity data collected over a decade with 10 years of newspaper articles published in response to high turbidity events, we assess the extent and sentiment of media attention to better understand the linkage between extreme natural events and how these relate to the media agenda. We find that as events increase in duration and intensity, their media coverage increases. These effects are more accentuated when the duration and intensity of an event surpass limits imposed by local infrastructure and practices.
Transcriptomic profiling analysis of human endometrial stromal cells treated with autologous platelet‐rich plasma
Authors: Kuroda Keiji , Matsumoto Akemi , Horikawa Takashi , Takamizawa Satoru , Ochiai Asako , Kawamura Kazuhiro , Nakagawa Koji , Sugiyama Rikikazu 
Published: January 2023

AbstractPurposeTo clarify the mechanisms of intrauterine platelet‐rich plasma (PRP) infusion that support embryo implantation in in vitro fertilization treatment.MethodsBlood and endometrial samples were collected from four infertile women. Human endometrial stromal cells (HESCs) were cultured and passaged equally into four cell culture dishes in each patient. Two were treated with PRP twice, and the other two were treated with vehicle. Subsequently, two cultures with and without PRP were decidualized with 8‐bromoadenosine 3′,5′‐cyclic AMP and progesterone for 5 days.ResultsThe gene expression in undifferentiated or decidualized HESCs with and without PRP was compared. In the microarray analysis, 381 and 63 differentially expressed genes were detected in undifferentiated and decidualized HESCs, respectively. In the undifferentiated HESCs, PRP was found to promote the gene expression associated with cell growth, tissue regeneration, proinflammatory response, and antibiotic effects. In decidualized HESCs, PRP was found to attenuate the gene expression involved in cell proliferation and inflammation by inhibiting the expression of phosphoinositide 3‐kinase signaling.ConclusionsPlatelet‐rich plasma regulates the reprogramming of cell proliferation and inflammation depending on menstrual cycle phases in an appropriate manner, suggesting that PRP has the potential to increase endometrial thickness in the proliferative phase and improve immune tolerance in the secretory phase.