bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improved use of faecal immunochemical tests for haemoglobin in the Scottish bowel screening programme
Authors: Digby Jayne , Fraser Callum G , Clark Gavin , Mowat Craig , Strachan Judith A , Steele Robert JC 
Published: May 2023

Objectives This study aimed to develop a risk-scoring model in the Scottish Bowel Screening Programme incorporating faecal haemoglobin concentration with other risk factors for colorectal cancer. Methods Data were collected for all individuals invited to participate in the Scottish Bowel Screening Programme between November 2017 and March 2018 including faecal haemoglobin concentration, age, sex, National Health Service Board, socioeconomic status, and screening history. Linkage with The Scottish Cancer Registry identified all screening participants diagnosed with colorectal cancer. Logistic regression was performed to identify which factors demonstrated significant association with colorectal cancer and could be used in the development of a risk-scoring model. Results Of 232,076 screening participants, 427 had colorectal cancer: 286 diagnosed following a screening colonoscopy and 141 arising after a negative screening test result giving an interval cancer proportion of 33.0%. Only faecal haemoglobin concentration and age showed a statistically significant association with colorectal cancer. Interval cancer proportion increased with age and was higher in women (38.1%) than men (27.5%). If positivity in women were mirrored in men at each age quintile interval cancer proportion would still have remained higher in women (33.2%). Moreover, an additional 1201 colonoscopies would be required to detect 11 colorectal cancers. Conclusions Development of a risk scoring model using early data from the Scottish Bowel Screening Programme was not feasible due to most variables showing insignificant association with colorectal cancer. Tailoring the faecal haemoglobin concentration threshold according to age could help to diminish some of the disparity in interval cancer proportion between women and men. Strategies to achieve sex equality using faecal haemoglobin concentration thresholds depend considerably on which variable is selected for equivalency and this requires further exploration.
CT-Verified Union Rate Following Arthrodesis of Ankle, Hindfoot, or Midfoot: A Systematic Review
Authors: Leslie Michael David , Schindler Christin , Rooke Gareth M. J. , Dodd Andrew 
Published: May 2023

Background: Ankle, hindfoot, and midfoot arthrodesis surgeries are standard procedures performed in orthopaedics to treat pain and functional disabilities. Although fusions can effectively improve pain and quality of life, nonunions remain a significant concern for surgeons. With the increased availability of computed tomography (CT), more surgeons rely on this modality for increased accuracy in determining whether a fusion was successful. The objective of this study was to report the rates of CT-confirmed fusion following ankle, hindfoot, or midfoot arthrodesis. Methods: A systematic review was performed using EMBASE, Medline, and Cochrane central register from January 2000 to March 2020. Inclusion criteria included studies with adults (<18 years) that received 1 or multiple fusions of the ankle, hindfoot, or midfoot. At least 75% of the study cohort must have been evaluated by CT postoperatively. Basic information was collected, including journal, author, year published, and level of evidence. Other specific information was collected, including patient risk factors, fusion site, surgical technique and fixation, adjuncts, union rates, criteria for successful fusion (%), and time of CT. Once data were collected, a descriptive and comparative analysis was performed. Results: Included studies (26, n = 1300) had an overall CT-confirmed fusion rate of 78.7% (69.6-87.7). Individual joints had an overall fusion rate of 83.0% (73-92.9). The highest rate of union was in the talonavicular joint (TNJ). Conclusion: These values are lower than previous studies, which found the same procedures to have greater than 90% fusion rates. With these updated figures, as confirmed by CT, surgeons will have better information for clinical decision making and when having informed consent conversations.
Extravasation of monoclonal antibodies commonly used in oncology: Classification, management and the role of the pharmacist
Authors: Bauters Tiene , Clottens Nele , Albert-Marí María A 
Published: May 2023

Introduction Extravasation by conventional cytotoxics has been well documented. While monoclonal antibodies are not considered to have the necrotic potential of some cytotoxic medicines, they require appropriate management in case of extravasation. However, fewer data are available on their classification and appropriate management when extravasation occurs. As monoclonal antibodies are being more commonly used in current daily oncology practice, this is an issue that cannot be ignored. Methods A scientific literature review on PubMed was conducted. All findings were critically appraised independently by 6 clinical pharmacists in order to provide a classification according to the extravasation hazard. Results A classification of non-conjugated and conjugated monoclonal antibodies according to extravasation hazard has been elaborated for different molecules frequently used in oncology. In addition, general management, in case extravasation of monoclonal antibodies occurs, has been proposed and the role of the pharmacist in the extravasation process has been described. Conclusion A classification of hazard extent of extravasation of monoclonal antibodies with concurrent management based on literature data and expert consensus has been elaborated. In addition, the role of the oncology pharmacist is crucial in terms of follow-up and documentation of the extravasated monoclonal antibody and management is described.
Liver cirrhosis following oxaliplatin-based adjuvant chemotherapy for rectal cancer
Authors: Huang Cheng , Chen Jv , Situ Yongli 
Published: May 2023

Introduction Oxaliplatin is a third-generation platinum-based antineoplastic drug that is widely used to treat patients with colorectal cancer. Reported adverse reactions include hepatic sinusoidal obstruction syndrome and liver fibrosis, but there are few reports of cirrhosis associated with chemotherapy. In addition, the pathogenesis of cirrhosis remains unclear. Case report We report a case of suspected oxaliplatin-induced liver cirrhosis, an adverse reaction that has not been previously reported. Management and outcome A 50-year-old Chinese man was diagnosed with rectal cancer and underwent laparoscopic radical rectal cancer surgery. The patient had a history of schistosomiasis, but history and serology showed no evidence of chronic liver disease. However, after five oxaliplatin-based chemotherapy cycles, the patient presented dramatic changes in liver morphology and developed splenomegaly, massive ascites, and elevated CA125 levels. Four months after discontinuing oxaliplatin, the patient's ascites had decreased significantly and CA125 levels declined from 505.3 to 124.6 mU/mL. After 15 weeks of follow-up, CA125 levels decreased to the normal range, and there has been no increase in ascites in this patient. Discussion Oxaliplatin-induced cirrhosis may be a serious complication and should be discontinued based on clinical evidence.
Six-Week Radiographic Follow-up Does Not Change Management for Nonoperatively Treated Extraarticular Metacarpal Shaft Fractures
Authors: Crawford Zachary , Ponce Robert B. , Moore Michael , Schumaier Adam , Ross Phillip , Stern Peter 
Published: May 2023

Background: Metacarpal fractures are common and account for over 30% of all hand fractures. Previous literature has shown similar outcomes between operative and nonoperative management of metacarpal shaft fractures. There is little information regarding the natural history of conservatively managed metacarpal shaft fractures and changes in management based on follow-up radiographs. Methods: A retrospective chart review was performed on all patients who presented to a single institution with an extraarticular metacarpal shaft or base fracture between 2015 and 2019. Results: Thirty-one patients with 37 metacarpal fractures were included for review: average age 41 years, male 48%, right hand dominant 91%, and average follow-up duration 7.3 weeks. At follow-up, a change of 2.4° in angulation ( P = .0005) and a change in shortening of 0.1 mm ( P = .0386) were noted over the 6-week time interval. No fractures had malrotation at presentation, and none developed malrotation during the follow-up period. Conclusions: Recent systematic reviews and meta-analysis have suggested that metacarpal fractures treated nonoperatively had similar outcomes to surgical fixation at 12 months of follow-up. We found that extraarticular metacarpal shaft fractures that do not meet operative indications at the initial visit should be expected to heal reliably with minimal change in angulation and shortening over time. The transition to removable brace or no brace at the 2-week follow-up is likely sufficient, and additional follow-up is not necessary and will reduce cost. Level of Evidence: Level III.
Optimization of collateral grading on computer tomography angiography
Authors: Pisani Leonardo , Haussen Diogo C , Mohammaden Mahmoud , Perry da Camara Catarina , Rodrigues Gabriel M , Bouslama Mehdi , Al-Bayati Alhamza , Hu Ranliang , Bianchi Nicholas , Ravindra Bhatt Nirav , Frankel Michael , Nogueira Raul G 
Published: May 2023

Background As compared to single-phase CTA (sCTA), multi-phase CTA (mCTA) has been shown to more accurately estimate collateral flow in acute ischemic stroke (AIS). We sought to determine the characterization of poor collaterals across the three different phases of the mCTA. We also attempted to establish the optimal arterio-venous contrast timing parameters on sCTA that would prevent false positive reads of poor collateral status. Methods We retrospectively screened consecutive patients admitted for possible thrombectomy from February 2018 to June 2019. Only cases with intracranial internal carotid artery (ICA) or main trunk of the middle cerebral artery (MCA) occlusion and both baseline mCTA and CT Perfusion available were included. Mean Hounsfield units (HU) of torcula and torcula/patent ICA ratio were used for the arterio-venous timing analysis. Results Of the 105 patients included, 35 (34%) received IV-tPA treatment and 65 (61.9%) underwent mechanical thrombectomy. A total of 20 patients (19%) had poor collaterals on the third-phase CTA (ground-truth). The first-phase CTA often underestimated collateral score (37/105 [35%], p < 0.01), however there were no significant differences across the second- and third-phases (5/105[5%], p  =  0.06. Venous opacification Youden's J point for identifying suboptimal sCTAs was found to be 207.9HU in the torcula (65% sensitivity,65% specificity) and 66.74% for torcula/patent ICA ratio (51% sensitivity,73% specificity). Conclusion A dual-phase CTA is significantly similar to a mCTA assessment of collateral score and may be applied at community-based centers. Absolute or relative thresholds for torcula opacification may be used to identify poor bolus-scan timing thus preventing erroneous assumptions of poor collaterals on sCTA.
Do South African international cricket pace bowlers have similar bowling volume and injury risk associates compared to other elite fast bowlers?
Authors: Christie Candice J. , McEwan Kayla , Munro Catherine E. , King Greg A. , Le Roux Adrian , Olivier Benita , Jackson Brandon , Manjra Shuaib , MacMillan Candice , Pote Lee 
Published: May 2023

Background Although many cricket-playing nations have conducted research on bowling volume (BV) and injury risk, this relationship amongst international South African pace bowlers is yet to be investigated. Environmental, socio-economic and training strategy differences warrant similar research in a South African context. The purpose of this preliminary study was to establish whether South African pace bowlers have similar BV and injury associates compared to other elite fast bowlers. Methods This study was a prospective, observational, cohort study that monitored match and training BV and injuries amongst pace bowlers playing for the South African national team between April 2017 and April 2019. A sample of convenience that included 14 bowlers was selected. Bowling volume was quantified as the number of deliveries bowled during training and competition. Acute-, chronic- and acute:chronic BV ratios were independently modelled as association variables. Results There were 39 injuries with the most being to the lumbar spine (25.64%). Moderate-to-low and a moderate-to-high acute:chronic bowling load ratios were associated with a lower risk of injury. Chronic bowling load was associated with injury (z  =  2.82, p  =  0.01). A low acute workload, low chronic workload, moderate-high chronic workload and moderate-low acute:chronic ratio were also associated with an increased risk of injury. Conclusion These findings confirm that there appears to be a dose–response effect between training BV and the likelihood of an injury occurring with a moderate-to-low and a moderate-to-high BV ratio being optimal. Considering the small sample size, the findings should be interpreted with caution.
Concomitant ligament injuries can be left untreated during surgery of distal radial fractures
Authors: Bakker Daniel , Derksen Bas M. , Kramer Simon B. , Cleffken Berry I. , Schep Niels W. L. 
Published: May 2023

Instability of the distal radioulnar joint and scapholunate dissociation may cause pain, functional impairment and subsequent arthrosis. There is no consensus about whether these injuries should be treated acutely in patients undergoing surgery for distal radial fractures. We conducted a prospective cohort study to determine whether concomitant distal radioulnar joint instability or scapholunate dissociation negatively influence patient-related outcomes in these patients. The primary outcome was the patient-reported wrist/hand evaluation at 6 and 12 months after surgery. Out of 62 patients, 58% and 27% had intraoperative distal radioulnar joint instability and scapholunate dissociation, respectively. No significant differences were found in patient-reported scores at follow-up between patients with stable and unstable distal radioulnar joints, nor between patients with and without scapholunate dissociation. Sixty-three per cent of patients with an unstable distal radioulnar joint during surgery were stable on retesting after 6 months. Our study suggests that a wait-and-see policy in these patients therefore seems reasonable. Level of evidence: III
Effect and Mechanism of Schizandrin A in the Treatment of Liver Cancer Using Network Pharmacology, Molecular Docking, and Target Validation
Authors: Wang Xiaohui , Zhou Lin , Zhang Tao , Chen Hui , Song Xinhao , Wang Feng 
Published: May 2023

Background Liver cancer is a common threat to human health. Schizandrin A (SA) has certain therapeutic effect on liver cancer, but its related mechanism of action is not clear. Elucidating this mechanism is of great significance for the development of drugs to target liver cancer. Objective The objective is to study the effect and mechanism of SA on liver cancer. Methods The potential targets of SA in the treatment of liver cancer were screened based on network pharmacology, and the core targets were further screened by protein network interaction. Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis was performed based on the core targets to find the key pathways of action. The results obtained for key targets and pathways were verified in vitro by pharmacological experiments with HepG2 cells. Specifically, an Enzyme Linked Immunosorbent assay (ELISA) kit was used to detect the content of key indicators (interleukin-1 (IL-1), Tumor Necrosis Factor-alpha (TNF-α), interleukin-6 (IL-6), interleukin-10 (IL-10), superoxide dismutase [SOD], malondialdehyde [MDA], interferon (IFN), and Glutathione peroxidase (GSH-px)), Quantitative Real-time Polymerase Chain Reaction (qRT-PCR) was used to detect the key messenger Ribonucleic Acid (mRNA) (phosphatidylinositol 3 kinase (PI3K), protein kinase B (Akt), vascular endothelial growth factor A (VEGFA), and Transforming Growth Factor Beta-1 (TGF-β1)) after drug intervention, and Western blotting (WB) detected the expression of key target proteins (p-PI3K, PI3K, p-Akt, and Akt). Results The results showed that SA mainly acts on IL-1β, TNF-α, IL-6, IL-10, SOD, MDA, TGF-β1, IFN, and VEGFA, affecting the PI3K-Akt signaling pathway and playing an anti-inflammatory role in the treatment of liver cancer. The experimental results showed that SA significantly reduced the inflammation level of HepG2 cells; improved the oxidative stress state (decreasing SOD level and increasing MDA level of cells); downregulated TGF-β1, VEGFA, PI3K, and Akt mRNA levels; and inhibited the expression of the PI3K-Akt signaling pathway. Conclusions SA has a significant anti-HepG2 effect, which may be achieved by reducing inflammation levels, improving oxidative stress state, and inhibiting the PI3K-Akt pathway.
Aerial Part Extract of Kummerowia striata as an Anti-Blood Stasis Agent in a Mouse Model of Hen-egg White Lysozyme-Induced Stagnant Blood Flow
Authors: Aoki Shui , Oku Hisae , Kitagawa Fumika , Inoue Naoki , Honda Chie 
Published: May 2023

Background/Objective Stagnant blood ( oketsu in Japanese) is considered a severe pathological condition in traditional Chinese and Japanese medicine. Kummerowia striata is known as a weed in Japan; however, in traditional Chinese medicines, it is used for detoxification and for treating colds, fevers, and bruises. To the best of our knowledge, there is no record of this plant, or its parts, being used as an anti-blood stasis agent. Herein, we demonstrated the effect of the 35% ethanol extract (KS) of the aerial part of K. striata on stagnant blood flow (BF) in the peripheral circulation using an in vivo assay. Methods Hen-egg white lysozyme (HEL) was injected into the tail vein of mice to induce stagnant BF, the pathology of which is similar to that of oketsu; then, the changes in BF were observed. Results The oral administration of KS (200 mg/kg) significantly improved HEL-induced BF decrease, suggesting that KS can improve blood stasis. Bioassay-guided fractionation of KS resulted in the isolation of 14 flavone and flavonol derivatives. As apigenin (1) and luteolin (2) reportedly have activity in this assay, here, the effects of isovitexin (3), vitexin (5), rhoifolin (12), and vicenin-1 (14) were examined. Compounds 5, 12, and 14 (20 µmol/kg) more effectively inhibited HEL-induced stagnant BF than 1, which was used as a positive control. Conclusion The aerial part of K. striata could be useful in the discovery of new leads for the prevention of stagnant blood syndrome.
Safety and tolerability of intramuscular and sublingual ketamine for psychiatric treatment in the Roots To Thrive ketamine-assisted therapy program: a retrospective chart review
Authors: Tsang Vivian W.L. , Tao Brendan , Dames Shannon , Walsh Zach , Kryskow Pam 
Published: May 2023

Background: In the last few years, ketamine is becoming increasingly common in the treatment of mental health conditions, but there is a lack of safety data informing intramuscular and sublingual dosing in a community-focused group psychotherapy setting. The Roots To Thrive ketamine-assisted therapy (RTT-KaT) program is a unique 12-week RTT-KaT program with 12 community of practice (a form of group therapy) sessions and three ketamine medicine sessions. Objectives: This study reports on adverse effects of intramuscular and sublingual ketamine dosing in a community group psychotherapy setting among 128 participants across four cohorts. Design: Retrospective chart review. Methods: A chart review of the RTT-KaT Program was performed retrospectively on four cohorts ( n = 128) that participated in 448 sessions running between September 2020 and December 2021. Baseline characteristics and adverse events were captured including medication administration before, during, and after RTT-KaT sessions. Analyses by session and by individual were conducted. Chi-square test with Yates’ continuity correction was used to assess side effects in subgroups from ketamine administration. Results: RTT-KaT was well tolerated with none of the 128 participants dropping out of the program. Primarily, of the 448 sessions, 49.16% had elevated blood pressures post-KaT session by session. In terms of other adverse effects, 12.05% of participant-sessions experienced nausea, 2.52% had an episode of vomiting, 3.35% had a headache, and seven participant-sessions experienced dizziness. Analysis by individual revealed congruent findings. Conclusion: These findings suggest good safety and tolerability for RTT-KaT among individuals seeking treatment for mental health issues. The majority of participants did not experience adverse reactions and the adverse events that were recorded involved transient symptoms that were resolved with rest and/or medications. The group therapy model described provides a comprehensive approach and presents a promising model for operating a KaT program in a community setting.
COVID-19 misinformation on YouTube: An analysis of its impact and subsequent online information searches for verification
Authors: Kessler Sabrina Heike , Humprecht Edda 
Published: May 2023

Objectives COVID-19 vaccination misinformation on YouTube can have negative effects on users. Some, after being exposed to such misinformation, may search online for information that either debunks or confirms it. This study's objective is to examine the impact of YouTube videos spreading misinformation about COVID-19 vaccination and the influencing variables, as well as subsequent information seeking and its effect on attitudes toward vaccination. Methods In this observational and survey study, we used a three-group pre-test and post-tests design ( N = 106 participants). We examined the effects of YouTube videos containing misinformation about COVID-19 vaccination on attitudes toward vaccination via surveys, employed screen recordings with integrated eye tracks to examine subsequent online information searches, and again surveyed participants to examine the effects of the individual searches on their attitudes. Results Receiving misinformation via video tended to have negative effects, mostly on unvaccinated participants. After watching the video, they believed and trusted less in the effectiveness of the vaccines. Internet searches led to more positive attitudes toward vaccination, regardless of vaccination status or prior beliefs. The valences of search words entered and search duration were independent of the participants’ prior attitudes. Misinforming content was rarely selected and perceived (read). In general, participants were more likely to perceive supportive and mostly neutral information about vaccination. Conclusion Misinformation about COVID-19 vaccination on YouTube can have a negative impact on recipients. Unvaccinated citizens in particular are a vulnerable group to online misinformation; therefore, it is important to take action against misinformation on YouTube. One approach could be to motivate users to verify online content by doing their own information search on the internet, which led to positive results in the study.