bluuebunny/crossref_metadata_2025_split huggingface dataset:
The GLA:D BACK self‐management adherence and competence checklist (SMAC Checklist)—Development, content validity and feasibility
Authors: Heiberg Bibi Dige , Ris Inge , Lauridsen Henrik Hein , Hartvigsen Jan , Myburgh Corrie , Kongsted Alice 
Published: May 2023

AbstractObjectivesTo unpack the complexity and impact of self‐management interventions targeting musculoskeletal health conditions, we need to learn more about treatment delivery in clinical settings. Fidelity evaluation can illuminate how complex treatments are delivered and help understand the elements that lead to the effect. The objective of this study was to develop a checklist for the evaluation of the clinicians’ delivery of structured patient education and exercise intervention for people with persistent back pain, the GLA:D Back intervention. The intent was to provide a checklist adaptable for the general delivery of self‐management interventions for musculoskeletal pain.MethodsWe derived items for the treatment delivery fidelity checklist from behaviour change techniques and theory about communication style. We applied a three‐step developmental process covering developing a preliminary fidelity intervention framework, validating checklist content and piloting and refining the checklist.ResultsWe developed the adaptable fidelity checklist, The GLA:D BACK Self‐management Adherence and Competence Checklist (SMAC Checklist). Evaluation of clinical practice using the checklist was feasible and acceptable by clinicians. Preliminary results indicate satisfactory observer agreement during pilot testing of the checklist.ConclusionThe GLA:D BACK Self‐management Adherence and Competence Checklist is a fidelity measurement tool for the assessment of the delivery of a self‐management supportive intervention for people with persistent back pain. The intention is that it can be useful as an adaptable tool for use across self‐management interventions for musculoskeletal pain.
A novel EGFR inhibitor, HNPMI, regulates apoptosis and oncogenesis by modulating BCL‐2/BAX and p53 in colon cancer
Authors: Kandhavelu Jeyalakshmi , Subramanian Kumar , Naidoo Vivash , Sebastianelli Giulia , Doan Phuong , Konda Mani Saravanan , Yapislar Hande , Haciosmanoglu Ebru , Arslan Leman , Ozer Samed , Thiyagarajan Ramesh , Candeias Nuno R. , Penny Clement , Kandhavelu Meenakshisundaram , Murugesan Akshaya 
Published: May 2023

AbstractBackground and PurposeColorectal cancer (CRC) is the second most lethal disease, with high mortality due to its heterogeneity and chemo‐resistance. Here, we have focused on the epidermal growth factor receptor (EGFR) as an effective therapeutic target in CRC and studied the effects of polyphenols known to modulate several key signalling mechanisms including EGFR signalling, associated with anti‐proliferative and anti‐metastatic properties.Experimental ApproachUsing ligand‐ and structure‐based cheminformatics, we developed three potent, selective alkylaminophenols, 2‐[(3,4‐dihydroquinolin‐1(2H)‐yl)(p‐tolyl)methyl]phenol (THTMP), 2‐[(1,2,3,4‐tetrahydroquinolin‐1‐yl)(4‐methoxyphenyl)methyl]phenol (THMPP) and N‐[2‐hydroxy‐5‐nitrophenyl(4′‐methylphenyl)methyl]indoline (HNPMI). These alkylaminophenols were assessed for EGFR interaction, EGFR‐pathway modulation, cytotoxic and apoptosis induction, caspase activation and transcriptional and translational regulation. The lead compound HNPMI was evaluated in mice bearing xenografts of CRC cells.Key ResultsOf the three alkylaminophenols tested, HNPMI exhibited the lowest IC50 in CRC cells and potential cytotoxic effects on other tumour cells. Modulation of EGFR pathway down‐regulated protein levels of osteopontin, survivin and cathepsin S, leading to apoptosis. Cell cycle analysis revealed that HNPMI induced G0/G1 phase arrest in CRC cells. HNPMI altered the mRNA for and protein levels of several apoptosis‐related proteins including caspase 3, BCL‐2 and p53. HNPMI down‐regulated the proteins crucial to oncogenesis in CRC cells. Assays in mice bearing CRC xenografts showed that HNPMI reduced the relative tumour volume.Conclusions and ImplicationsHNPMI is a promising EGFR inhibitor for clinical translation. HNPMI regulated apoptosis and oncogenesis by modulating BCL‐2/BAX and p53 in CRC cell lines, showing potential as a therapeutic agent in the treatment of CRC.
Clinical and radiographic assessment of circular versus triangular cross‐section neck implants in the posterior maxilla: Five‐year follow‐up of a randomized controlled trial
Authors: Hurtgen Alexandre , Seidel Laurence , Manni Lou Li , Liegeois Lemmy , Lecloux Geoffrey , Lambert France 
Published: May 2023

AbstractObjectivesDental implants with a triangular neck design have been developed in order to maintain peri‐implant bone. The primary aim of this randomized controlled trial (RCT) was to assess after 5 years the peri‐implant bone stability and the peri‐implant soft tissue conditions with this new triangular implant neck design compared to a conventional round neck implant design.Material and MethodsThis is a secondary evaluation of a RCT including 34 patients. Patients were recalled after 1, 3, and finally 5 years to assess implant survival and peri‐implant bone levels using standardized radiographs. Peri‐implant soft tissue health was also evaluated by recording probing depth, plaque index and Bleeding on Probing. Patient Reported Outcome Measures (PROMs) and the Pink Esthetic Score were also assessed.ResultsNo implant loss occurred during the 5‐year follow up period. The mean ± SD proximal bone remodeling after 5 years reached 0.38 ± 0.39 mm for the circular design and 0.29 ± 0.58 mm for the triangular design (p = .49). Peri‐implant soft tissue health parameters and PROMs were found to be comparable. Altogether, 80% of implants presented peri‐implant mucositis whereas one implant (4%) displayed sings of peri‐implantitis.ConclusionThe 5‐year evaluation of the triangular neck implants showed similar results to the circular neck implants.
Hypericin as a potential drug for treating Alzheimer's disease and type 2 diabetes with a view to drug repositioning
Authors: Yuan Xin , Yan Fei , Gao Li‐Hui , Ma Qian‐Hui , Wang Ju 
Published: May 2023

AbstractAimsAlzheimer's disease (AD) and type 2 diabetes (T2D) are two of the most common diseases in elderly population and they have a high rate of comorbidity. Study has revealed that T2D is a major risk factor of AD, and thus exploring therapeutic approaches that can target both diseases has drawn much interest in recent years. In this study, we tried to explore drugs that could be potentially used to prevent or treat both AD and T2D via a drug repositioning approach.MethodsWe first searched the known drugs that may be effective to T2D treatment based on the network distance between the T2D‐associated genes and drugs deposited in the DrugBank database. Then, via molecular docking, we further screened these drugs by examining their interaction with islet amyloid polypeptide (IAPP) and Aβ42 peptide, the key components involved in the pathogenesis of T2D or AD. Finally, the binding between the selected drug candidates and the target proteins was verified by molecular dynamics (MD) simulation; and the potential function of the drug candidates and the corresponding targets were analyzed.ResultsFrom multiple resources, 734 T2D‐associated genes were collected, and a list of 1109 drug candidates for T2D was obtained. We found that hypericin had the lowest binding energy and the most stable interaction with either IAPP or Aβ42 peptide. In addition, we also found that the target genes regulated by hypericin were differentially expressed in the tissues related to the two diseases.ConclusionOur results show that hypericin may be able to bind with IAPP and Aβ42 stably and prevent their accumulation, and thus could be a promising drug candidate for treating the comorbidity of AD and T2D.
Results of the interim analysis of a prospective, multicenter, observational study of small subepithelial lesions in the stomach
Authors: Iwamuro Masaya , Mitsuhashi Toshiharu , Inaba Tomoki , Matsueda Kazuhiro , Nagahara Teruya , Takeuchi Yoji , Doyama Hisashi , Mizuno Masakatsu , Yada Tomoyuki , Kawai Yoshinari , Nakamura Jun , Matsubara Minoru , Nebiki Hiroko , Niimi Keiko , Toyokawa Tatsuya , Takenaka Ryuta , Takeda Sho , Tanaka Shouichi , Nishimura Mamoru , Tsuzuki Takao , Akahoshi Kazuya , Furuta Takahisa , Haruma Ken , Okada Hiroyuki 
Published: May 2023

ObjectivesLong‐term outcomes of gastric subepithelial lesions have not been elucidated. To reveal the natural history, we initiated a prospective, 10‐year follow‐up of patients with small (≤20 mm) gastric subepithelial lesions in September 2014. Here, we report the results of an interim analysis of a prospective observational study.MethodsIn total, 567 patients with 610 lesions were prospectively registered between September 2014 and August 2016. The location, size, morphology, and number of subepithelial lesions were recorded on a web‐based case report form. This study has been conducted as an Academic Committee Working Group of the Japan Gastroenterological Endoscopy Society.ResultsThe endoscopic follow‐up period was 4.60 ± 1.73 years (mean ± standard deviation), and survival data were investigated for 5.28 ± 1.68 years. This interim analysis revealed that the estimated cumulative incidence of a size increase ≥5 mm, after accounting for patients' death and resection of the tumor as competing risk events, was 4.5% at 5 years. In addition, the estimated cumulative incidence of lesion size increase ≥5 mm or resection of lesions was 7.9% at 5 years, and that of size increase ≥10 mm or resection of lesions was 4.5% at 5 years.ConclusionThese results indicate that approximately one in 13 patients with small (≤20 mm) gastric subepithelial lesions may require resection or further investigation for increased tumor size (≥5 mm) within 5 years.
Clinical correlates of fear of falling in progressive supranuclear palsy and multiple system atrophy
Authors: Martínez‐Villota Viviana A. , Terroba‐Chambi Cinthia , Castillo‐Torres Sergio A. , Rossi Malco , Merello Marcelo 
Published: May 2023

AbstractBackground and purposeClinical correlates of fear of falling (FoF) are scarcely studied in patients with progressive supranuclear palsy (PSP) and multiple system atrophy (MSA). This study was undertaken to evaluate the clinical correlates of FoF in PSP and MSA.MethodsThis cross‐sectional study features motor, cognitive, and psychiatric assessment and longitudinal evaluation of falls and FoF at 6‐month follow‐up.ResultsTwenty‐one patients with PSP‐parkinsonism, 22 patients with MSA (13 parkinsonian type and nine cerebellar type), and 22 healthy controls were evaluated; 76.2% of patients with PSP and 86.4% of patients with MSA had FoF regardless of falls. Berg Balance Scale (p < 0.001), Tinetti Mobility Test (p < 0.01), Beck Anxiety Inventory (p = 0.001), and Beck Depression Inventory‐II (p = 0.01) correlated with FoF in patients with PSP and MSA, whereas Timed Up and Go test (p = 0.01) and Starkstein Apathy Scale correlated only in MSA (p = 0.04).ConclusionsMobility, balance, and gait performance as well as anxiety and depression in PSP and MSA, and apathy in MSA, were determinants of FoF. These findings underline the importance of a multidisciplinary approach to FoF in neurodegenerative atypical parkinsonism.
TheCYP24A1gene variant rs2762943 is associated with low serum 1,25‐dihydroxyvitamin D levels in multiple sclerosis patients
Authors: Malhotra Sunny , Midaglia Luciana , Chuquisana Omar , Patsopoulos Nikolaos A. , Ferrer Roser , Giralt Marina , Fissolo Nicolas , Gil‐Varea Elia , Triviño Juan Carlos , Lünemann Jan D. , Montalban Xavier , Comabella Manuel 
Published: May 2023

AbstractBackground and purposeVitamin D is considered to play a role in multiple sclerosis (MS) etiopathogenesis. A polymorphism in theCYP24A1gene, rs2762943, was recently identified that was associated with an increased MS risk.CYP24A1encodes a protein involved in the catabolism of the active form of vitamin D. The immunological effects of carrying the rs2762943 risk allele were investigated, as well as its role as genetic modifier.MethodsSerum levels of 25‐hydroxyvitamin D and 1,25‐dihydroxyvitamin D (1,25(OH)2D) were measured in a cohort of 167 MS patients. In a subgroup of patients, expression levels of major histocompatibility complex class II and co‐stimulatory molecules were determined by flow cytometry, and serum levels of pro‐inflammatory (interferon gamma, granulocyte macrophage colony‐stimulating factor, C‐X‐C motif chemokine ligand 13) and anti‐inflammatory (interleukin 10) cytokines and neurofilament light chain were measured by single‐molecule array assays. The effect of the rs2762943 polymorphism on disease activity and disability measures was evaluated in 340 MS patients.ResultsCompared to non‐carriers, carriers of the rs2762943 risk allele were characterized by reduced levels of 1,25(OH)2D (p = 0.0001) and elevated levels of interferon gamma (p = 0.03) and granulocyte macrophage colony‐stimulating factor (p = 0.008), whereas no significant differences were observed for the other markers. The presence of the rs2762943 risk allele had no significant impact on disease activity and disability outcomes during follow‐up. However, risk allele carriers were younger at disease onset (p = 0.04).ConclusionsThese findings suggest that theCYP24A1rs2762943 polymorphism plays a more important role in MS susceptibility than in disease prognosis and is associated with lower 1,25(OH)2D levels and a heightened pro‐inflammatory environment in MS patients.
Reporting hypoglycaemia as a hospital‐acquired complication: assessing biochemical and clinical validity
Authors: Dharma Joanna F. M. , Polmear Christine , Fourlanos Spiros , Kyi Mervyn 
Published: May 2023

AbstractBackground and AimsGiven treatment‐related hypoglycaemia in hospitals can lead to adverse outcomes, the Australian Commission on Safety and Quality in Health Care has included hypoglycaemia as a reportable hospital‐acquired complication (HAC) with financial disincentives. However, the designation of a hypoglycaemia HAC relies on clinical coding without a defined glucose threshold or clinical context. We assessed the biochemical validity and clinical relevance of a hypoglycaemia HAC.MethodsWe performed a retrospective review on patients discharged from the Northern Health hospitals between March and August 2021 who were designated as experiencing a hypoglycaemia HAC. We assessed cases for biochemical validity (glucose <4.0 mmol), clinical context and whether they were treatment‐related (treatment with insulin or sulphonylurea). We then compared this cohort with a hospital‐wide glucometric survey based on a point‐prevalence study to determine the proportion of individuals with hypoglycaemic events that were designated as hypoglycaemia HAC.ResultsTwo hundred fifty‐six admissions were coded as hypoglycaemia HAC. Eleven (4%) did not have a biochemically valid episode. Of the valid cases, 34 (14%) were not treated with any glucose‐lowering medication and 11 (4%) were treated with noninsulin, nonsulphonylurea glucose‐lowering medication. Two hundred admissions (78%) were considered treatment‐related HAC. Of 139 individuals with diabetes identified in the hospital‐wide point‐prevalence study, 25 (18%) had biochemical evidence for hypoglycaemia: 22 were treatment‐related, of which 68% were not coded as HAC.ConclusionGiven safety and cost implications, the designation of hypoglycaemia HAC requires a standardised definition incorporating a biochemical threshold and clinical context. We propose a clinically relevant definition of hypoglycaemia HAC to promote safe diabetes care.
Knowledge mapping of extracellular vesicles in wound healing: A bibliometric analysis (2002‐2022)
Authors: Niu Shao‐hui , Li Bei , Gu Han‐cheng , Huang Qiang , Cheng Ya‐qing , Wang Chang , Cao Gang , Yang Qiaoli , Zhang Dong‐ping , Cao Jian‐chun 
Published: May 2023

AbstractExtracellular vesicles in wound healing have become an active research field with substantial value and potential. Nevertheless, there are few bibliometric studies in this field. We aimed to visualise the research hot spots and trends of extracellular vesicles in wound healing using a bibliometric analysis to help understand the future development of basic and clinical research. The articles and reviews regarding extracellular vesicles in the wound healing were selected from the Web of Science Core Collection. VOSviewers, CiteSpace and R package “bibliometric” were used to conduct this bibliometric analysis. A total of 1225 articles from 56 countries led by China and the United States were included. The number of publications related to extracellular vesicles increased year by year. Shanghai Jiaotong University, Huazhong University of Science and Technology, Sun Yat‐sen University and Central South University are the main research institutions. International Journal of Molecular Sciences is the most popular journal in this field, while Stem Cell Research & Therapy is the most frequently cited journal. These papers come from 7546 authors, among which Zhang Wei has published the most papers and Zhang Bin has the most cocited papers. The research on the treatment strategy of extracellular vesicles in the process of wound healing is the main topic in this field. “exosomes”, “miRNA”, “angiogenesis”, “regenerative medicine”, “inflammation” and “diabetic wound” are the main key words of emerging research hotspots. This is the first bibliometric study, which comprehensively summarises the research trend and development of extracellular vesicles and exocrine bodies in wound healing. These informations determine the latest research frontiers and hot directions, and provide reference for the study of extracellular vesicles and exosomes.
Persona Design: Representativeness and Empathy through Cultural Integration
Authors: Dreamson Neal , Rhee Joohwan , Han Jungseok , Lee Minjoo , Ro Yunjoo 
Published: May 2023

AbstractPersona design aims to increase students’ ability to understand their target users and address their needs. Yet, there is a lack of conceptual frameworks that help students systematically conceptualise user needs, specifically the two key requirements of persona design: representativeness and empathy. In this study, we find an alternative method using cultural dimensions to ensure that students conceptualise personas by reflecting representativeness and empathy in a systematic way. We justify cultural dimensions and engagement aspects and suggest a classified table for representative and empathetic persona design. In a design course, we analyse personas created by students in two different groups with the table (Group 1, n = 16) and without the table (Group 2, n = 17) through comparative thematic analysis to evaluate the qualities of representativeness and empathy. As a result, the cognitive aspect of engagement is predominated in Group 2, whereas the cognitive, emotional, behavioural, and social aspects of engagement are evenly distributed in Group 1. 11 cultural dimensions are identified in Group 2, whereas 20 cultural dimensions are identified in Group 1. In Group 2, a particular dimension is predominant (44.4% of individualism), whereas, in Group 1, the rate of the most used dimension is 12.2% (femininity and collectivism). The study results indicate that the method allows students to diversify and deepen their understanding of user needs and thereby conceptualising personas in in‐depth and analytical ways. From instructional perspectives, it can be used by educators to help students systematically conceptualise user needs in design activities.
Dietary sodium/potassium intake and cognitive impairment in older patients with hypertension: Data from NHANES 2011–2014
Authors: Kou Chengkun , Zhao Xu , Fan Xin , Lin Xin , Wang Qiongying , Yu Jing 
Published: May 2023

AbstractThis study aimed to assess the relationship between dietary sodium/potassium intake and cognition in elderly individuals with hypertension. We designed a cross‐sectional study based on the 2011–2014 National Health and Nutrition Examination Survey (NHANES) 2011–2014. A multivariable‐logistic regression analysis was performed to analyze the relationship between sodium/potassium intake and cognitive impairment. Restricted cubic spline (RCS) based on regression analysis to assess the nonlinear dose‐response relationship between dietary sodium intake and cognitive performance. Out of the 2276 participants included in this study, 1670 patients had hypertension. Compared with the lowest quartile of dietary sodium intake, the lowest weighted odds ratio of cognitive impairment in DSST was observed in Q4 (OR = 0.45, 0.29–0.70), and a similar trend was observed in AFT (OR = 0.34, 0.18–0.65). After adjusting the covariates, the lowest weighted multivariable‐adjusted OR of cognitive impairment in DSST were also observed in Q4 (OR = 0.47, 0.26‐0.84) compared with the lowest quartile of dietary sodium intake. The RCS results showed that dietary sodium intake was U‐shaped and associated with the risk of cognitive impairment in the DSST (Pnon–linearity = 0.0067). In addition, no significant association was observed between dietary potassium intake and different dimensions of cognitive performance. In conclusion, excessively high and low low dietary sodium were associated with impairment of specific processing speed, sustained attention, and working memory for elderly patients with hypertension in the United States. However, no association was observed between dietary potassium intake and cognition.
Evaluating a treatment selection approach for online single‐session interventions for adolescent depression
Authors: Ahuvia Isaac L. , Mullarkey Michael C. , Sung Jenna Y. , Fox Kathryn R. , Schleider Jessica L. 
Published: May 2023

BackgroundThe question ‘what works for whom’ is essential to mental health research, as matching individuals to the treatment best suited to their needs has the potential to maximize the effectiveness of existing approaches. Digitally administered single‐session interventions (SSIs) are effective means of reducing depressive symptoms in adolescence, with potential for rapid, large‐scale implementation. However, little is known about which SSIs work best for different adolescents.ObjectiveWe created and tested a treatment selection algorithm for use with two SSIs targeting depression in high‐symptom adolescents from across the United States.MethodsUsing data from a large‐scale RCT comparing two evidence‐based SSIs (N = 996; ClinicalTrials.gov: NCT04634903), we utilized a Personalized Advantage Index approach to create and evaluate a treatment‐matching algorithm for these interventions. The two interventions were Project Personality (PP; N = 482), an intervention teaching that traits and symptoms are malleable (a ‘growth mindset’), and the Action Brings Change Project (ABC; N = 514), a behavioral activation intervention.ResultsResults indicated no significant difference in 3‐month depression outcomes between participants assigned to their matched intervention and those assigned to their nonmatched intervention. The relationship between predicted response to intervention (RTI) and observed RTI was weak for both interventions (r = .39 for PP, r = .24 for ABC). Moreover, the correlation between a participants' predicted RTI for PP and their predicted RTI for ABC was very high (r = .79).ConclusionsThe utility of treatment selection approaches for SSIs targeting adolescent depression appears limited. Results suggest that both (a) predicting RTI for SSIs is relatively challenging, and (b) the factors that predict RTI for SSIs are similar regardless of the content of the intervention. Given their overall effectiveness and their low‐intensity, low‐cost nature, increasing youths' access to both digital SSIs may carry more public health utility than additional treatment‐matching efforts.