bluuebunny/crossref_metadata_2025_split huggingface dataset:
DE SIMPLICIUS À ḤUNAYN: LA TRANSMISSION D'UNE DOXOGRAPHIE DANS LES RÉSUMÉS AU TRAITÉ SUR LES ÉLÉMENTS DE GALIEN
Authors: Brémond Mathilde 
Published: February 2023

RésuméCet article s’intéresse à deux doxographies présentes dans des résumés et abrégés de Ḥunayn au traité Sur les Éléments de Galien. Nous retraçons l’origine de ces doxographies, depuis des scolies grecques au traité galénique jusqu’au Commentaire à la Physique de Simplicius, dont nous montrons qu’il en est la source ultime. Nous indiquons aussi que le Commentaire de Simplicius a inspiré une interprétation de Parménide et Mélissos que nous trouvons chez Ḥunayn. Cela nous permet de voir des traces du Commentaire à la Physique de Simplicius dans le monde arabe et d’apporter quelques éclaircissements sur la construction de ces résumés à l’oeuvre de Galien que l’on appelle les Summaria alexandrinorum.
IBN AL-HAYṮAM, SUR LE MIROIR ARDENT PARABOLIQUE
Authors: Rashed Roshdi 
Published: February 2023

RésuméCet article comporte l’editio princeps du traité d’Ibn al-Hayṯam « Sur le miroir ardent parabolique », Fī al-marāyā al-muḥriqa bi-al-quṭūʿ, ainsi que sa première traduction en français. Nous examinons la place qu’il occupe dans l’histoire du miroir parabolique durant plus d’un millénaire et demi, aussi bien en grec qu’en arabe et en latin.
Dynamics of the Wave‐Driven Circulation in the Lee of Nearshore Reefs
Authors: da Silva Renan F. , Hansen Jeff E. , Lowe Ryan J. , Rijnsdorp Dirk P. , Buckley Mark L. 
Published: February 2023

AbstractNearshore rocky reefs with scales of order 10–100 m are common along the world's coastline and often shape wave‐driven hydrodynamics and shoreline morphology in their lee. The interaction of waves with these reefs generally results in either two or four‐cell mean circulation systems (2CC and 4CC, respectively), with diverging flows behind the reefs and at the shoreline in the 2CC case and flows that diverge in the lee and converge at the shoreline in the 4CC case. By applying a phase‐resolving wave‐flow model to conduct a detailed analysis of mean momentum balances for waves interacting with nearshore reefs, we develop an understanding of the drivers of 2CC and 4CC flow dynamics and how they vary for different reef geometries and wave and water level conditions. The 2CC or 4CC patterns were primarily driven by alongshore pressure gradients toward the exposed (nonreef fronted) or reef‐fronted beach. These alongshore pressure gradients were dependent on the cross‐shore setup dynamics governed by the balance between pressure (i.e., related to the setup) and radiation stress gradients, and mean bottom stresses exerted on the water column. If shoreline wave setup in the lee of the reef was less than the exposed beach, a 4CC pattern developed with convergent flow at the shoreline in the lee of the reef; otherwise, a 2CC emerged with divergent flow at the shoreline. Across the parameter space investigated, reef roughness, distance to the shoreline, and beach slope were the three parameters most likely to change the flow patterns between 2CC and 4CC.
Anthropometric estimators of abdominal fat volume in adults with overweight and obesity
Authors: Michel Sophia , Linder Nicolas , Linder Anna , Eggebrecht Tobias , Schaudinn Alexander , Blüher Matthias , Dietrich Arne , Denecke Timm , Busse Harald 
Published: February 2023

Abstract
Background/Objectives
To evaluate anthropometric measures for the prediction of whole-abdominal adipose tissue volumes VXAT (subcutaneous VSAT, visceral VVAT and total VTAT) in patients with obesity.

Subjects/Methods
A total of 181 patients (108 women) with overweight or obesity were analyzed retrospectively. MRI data (1.5 T) were available from independent clinical trials at a single institution (Integrated Research and Treatment Center of Obesity, University of Leipzig). A custom-made software was used for automated tissue segmentation. Anthropometric parameters (AP) were circumferences of the waist (WC) and hip (HC), waist-to-hip ratio (WHR), waist-to-height ratio (WHtR) and the (hypothetical) hip-to-height ratio (HHtR). Agreement was evaluated by standard deviations sd% of percent differences between estimated volumes (using results of linear AP–VXAT regression) and measured ones as well as Pearson’s correlation coefficient r.

Results
For SAT volume estimation, the smallest sd% for all patients was seen for HC (25.1%) closely followed by HHtR (25.2%). Sex-specific results for females (17.5% for BMI and 17.2% for HC) and males (20.7% for WC) agreed better. VAT volumes could not be estimated reliably by any of the anthropometric measures considered here. TAT volumes in a mixed population could be best estimated by BMI closely followed by WC (roughly 17.5%). A sex-specific consideration reduced the deviations to around 16% for females (BMI and WC) and below 14% for males (WC).

Conclusions
We suggest the use of sex-specific parameters–BMI or HC for females and WC for males–for the estimation of abdominal SAT and TAT volumes in patients with overweight or obesity.
Identification of brain cell types underlying genetic association with word reading and correlated traits
Authors: Price Kaitlyn M. , Wigg Karen G. , Nigam Anukrati , Feng Yu , Blokland Kirsten , Wilkinson Margaret , Kerr Elizabeth N. , Guger Sharon L. , Lovett Maureen W. , Strug Lisa J. , Tripathy Shreejoy J. , Barr Cathy L. 
Published: February 2023

AbstractNeuroimaging studies implicate multiple cortical regions in reading ability/disability. However, the neural cell types integral to the reading process are unknown. To contribute to this gap in knowledge, we integrated genetic results from genome-wide association studies for word reading (n = 5054) with gene expression datasets from adult/fetal human brain. Linkage disequilibrium score regression (LDSC) suggested that variants associated with word reading were enriched in genes expressed in adult excitatory neurons, specifically layer 5 and 6 FEZF2 expressing neurons and intratelencephalic (IT) neurons, which express the marker genes LINC00507, THEMIS, or RORB. Inhibitory neurons (VIP, SST, and PVALB) were also found. This finding was interesting as neurometabolite studies previously implicated excitatory-inhibitory imbalances in the etiology of reading disabilities (RD). We also tested traits that shared genetic etiology with word reading (previously determined by polygenic risk scores): attention-deficit/hyperactivity disorder (ADHD), educational attainment, and cognitive ability. For ADHD, we identified enrichment in L4 IT adult excitatory neurons. For educational attainment and cognitive ability, we confirmed previous studies identifying multiple subclasses of adult cortical excitatory and inhibitory neurons, as well as astrocytes and oligodendrocytes. For educational attainment and cognitive ability, we also identified enrichment in multiple fetal cortical excitatory and inhibitory neurons, intermediate progenitor cells, and radial glial cells. In summary, this study supports a role of excitatory and inhibitory neurons in reading and excitatory neurons in ADHD and contributes new information on fetal cell types enriched in educational attainment and cognitive ability, thereby improving our understanding of the neurobiological basis of reading/correlated traits.
HMMR promotes prostate cancer proliferation and metastasis via AURKA/mTORC2/E2F1 positive feedback loop
Authors: Guo Kaixuan , Liu Cheng , Shi Juanyi , Lai Cong , Gao Ze , Luo Jiawen , Li Zhuohang , Tang Zhuang , Li Kuiqing , Xu Kewei 
Published: February 2023

AbstractAlthough dysregulated HMMR is linked to prostate cancer (PCa) prognosis, the precise mechanisms remain unclear. Here, we sought to elucidate the role of HMMR in PCa progression as well as underlying mechanism. Herein, we found that upregulation of HMMR frequently observed in PCa samples and was associated with poor prognosis. Additionally, HMMR significantly promoted PCa proliferation and metastasis through gain- and loss-of function approaches in vitro and in vivo. Mechanistically, HMMR may interact with AURKA and elevated AURKA protein level through inhibiting ubiquitination-mediated degradation, which subsequently activated mTORC2/AKT pathway to ensure the reinforcement of PCa progression. Moreover, upregulated E2F1 caused from sustained activation of mTORC2/AKT pathway in turn function as transcription factor to promote HMMR transcription, thereby forming a positive feedback loop to trigger PCa progression. Importantly, administration of the mTOR inhibitor partially antagonised HMMR-mediated PCa progression in vivo. In summary, we not only reveal a novel possible post-translation mechanism mediated by HMMR involved in AURKA regulation, but also describe a positive feedback loop that contributes to PCa deterioration, suggesting HMMR may serve as a potential promising therapeutic target in PCa.
A polystyrene/silica hybrid nanomatrix formed in natural rubber
Authors: Thi Nghiem Thuong , Yusof Nurul Hayati , Kawahara Seiichi 
Published: February 2023

AbstractOur work aims to investigate the morphology and properties of natural rubber (NR) dispersed in a polystyrene/silica hybrid nanomatrix. The hybrid nanomatrix structure was formed by the graft copolymerization of vinyltriethoxysilane onto NR grafted with styrene. This hybrid nanomatrix structure was composed of nanosilica with a size of less than 100 nm, and the incorporation of polystyrene resulted in outstanding mechanical and viscoelastic properties. The tensile strength of NR with the hybrid nanomatrix structure was 23 MPa, and the storage modulus was 2.54 MPa, which were 2.5 and 15 times higher than those of the silica nanomatrix. The outstanding mechanical and viscoelastic properties of this NR material were attributed to the formation of the hybrid nanomatrix structure. The roles of polystyrene and silica and their synergetic effect were clarified by investigating the morphology and properties of the hybrid nanomatrix after acetone extraction and annealing.
Regulators of proteostasis are translationally repressed in fibroblasts from patients with sporadic and LRRK2-G2019S Parkinson’s disease
Authors: Flinkman Dani , Hong Ye , Gnjatovic Jelena , Deshpande Prasannakumar , Ortutay Zsuzsanna , Peltonen Sirkku , Kaasinen Valtteri , James Peter , Coffey Eleanor 
Published: February 2023

AbstractDeficits in protein synthesis are associated with Parkinson’s disease (PD). However, it is not known which proteins are affected or if there are synthesis differences between patients with sporadic and Leucine-Rich Repeat Kinase 2 (LRRK2) G2019S PD, the most common monogenic form. Here we used bio-orthogonal non-canonical amino acid tagging for global analysis of newly translated proteins in fibroblasts from sporadic and LRKK2-G2019S patients. Quantitative proteomic analysis revealed that several nascent proteins were reduced in PD samples compared to healthy without any significant change in mRNA levels. Using targeted proteomics, we validated which of these proteins remained dysregulated at the static proteome level and found that regulators of endo-lysosomal sorting, mRNA processing and components of the translation machinery remained low. These proteins included autophagy-related protein 9A (ATG9A) and translational stability regulator YTH N6-ethyladenosine RNA binding protein 3 (YTHDF3). Notably, 77% of the affected proteins in sporadic patients were also repressed in LRRK2-G2019S patients (False discovery rate (FDR) < 0.05) in both sporadic and LRRK2-G2019S samples. This analysis of nascent proteomes from PD patient skin cells reveals that regulators of proteostasis are repressed in both sporadic and LRRK2-G2019S PD.
In silico drug discovery of SIRT2 inhibitors from natural source as anticancer agents
Authors: Ibrahim Mahmoud A. A. , Abdeljawaad Khlood A. A. , Roshdy Eslam , Mohamed Dina E. M. , Ali Taha F. S. , Gabr Gamal A. , Jaragh-Alhadad Laila A. , Mekhemer Gamal A. H. , Shawky Ahmed M. , Sidhom Peter A. , Abdelrahman Alaa H. M. 
Published: February 2023

AbstractSirtuin 2 (SIRT2) is a member of the sirtuin protein family, which includes lysine deacylases that are NAD+-dependent and organize several biological processes. Different forms of cancer have been associated with dysregulation of SIRT2 activity. Hence, identifying potent inhibitors for SIRT2 has piqued considerable attention in the drug discovery community. In the current study, the Natural Products Atlas (NPAtlas) database was mined to hunt potential SIRT2 inhibitors utilizing in silico techniques. Initially, the performance of the employed docking protocol to anticipate ligand-SIRT2 binding mode was assessed according to the accessible experimental data. Based on the predicted docking scores, the most promising NPAtlas molecules were selected and submitted to molecular dynamics (MD) simulations, followed by binding energy computations. Based on the MM-GBSA binding energy estimations over a 200 ns MD course, three NPAtlas compounds, namely NPA009578, NPA006805, and NPA001884, were identified with better ΔGbindingtowards SIRT2 protein than the native ligand (SirReal2) with values of − 59.9, − 57.4, − 53.5, and − 49.7 kcal/mol, respectively. On the basis of structural and energetic assessments, the identified NPAtlas compounds were confirmed to be steady over a 200 ns MD course. The drug-likeness and pharmacokinetic characteristics of the identified NPAtlas molecules were anticipated, and robust bioavailability was predicted. Conclusively, the current results propose potent inhibitors for SIRT2 deserving more in vitro/in vivo investigation.
Scenarios of land use and land cover change in the Colombian Amazon to evaluate alternative post-conflict pathways
Authors: Agudelo-Hz William-J. , Castillo-Barrera Natalia-C. , Uriel Murcia-García 
Published: February 2023

AbstractPastures and crops have been expanding at an accelerated rate in the forests of the Colombian Amazon since the peace accords were signed in 2016. The rapid loss of tropical rainforests is threatening the integrity of protected areas and connectivity in the Amazon and other natural regions. In the context of the post-conflict stage, a set of land use and land cover change scenarios were constructed for the Colombian Amazon for the year 2040, using expert coherent narratives. Three scenarios were designed: trend, extractivist, and sustainable development. Historic land use change and driving factors were analyzed throughout 14 transitions between the years 2002 and 2016, based on the interpretation of Landsat images and their relationship with 29 driving factors using artificial neural networks. The Markov chain model was calculated for the transitions, and the change allocation model was parameterized to spatially simulate the scenarios. The results showed that the LULC model calibration and validation were satisfactory (0.91). The sustainable development scenario that considers strong policies for the conservation of forests and implementation of sustainable production projects was the option with greater values for conserved forests and secondary vegetation in recovery, adding ~ 42 million hectares by 2040. The other scenarios showed that the Colombian Amazon will lose ~ 2 million hectares of forests in the trend scenario and ~ 4.3 million hectares in the extractivist scenario, based on the reference year (2016). In the trend scenario, pastures and crops could increase by 48%; and, in the extractivist scenario, these would increase by 117%, changing from ~ 3.9 to ~ 8.6 million hectares. We hope that the scientific contribution of this study will be relevant for informed discussion in decision-making and provide a framework for building a peaceful territory.
The relationship of social determinants and distress in newly diagnosed cancer patients
Authors: Okeke Brandon , Hillmon Cheron , Jones Jasmine , Obanigba Grace , Obi Ann , Nkansah Meagan , Odiase Nicholas , Khanipov Kamil , Okereke Ikenna C. 
Published: February 2023

AbstractPatients with a new cancer diagnosis can experience distress when diagnosed. There are disparities in treatment of cancer patients based on social determinants, but minimal research exists on the relationship of those social determinants and distress after a new cancer diagnosis. Our goals were to determine the social determinants associated with distress after a new cancer diagnosis and determine the relationship of distress with outcome. Patients with a new cancer diagnosis at one institution from January 2019 to December 2020 were analyzed. Patients were given the National Comprehensive Cancer Network (NCCN) distress thermometer during their first visit. Demographics, tumor characteristics, clinical variables and survival were recorded. Patients were also asked to share specific factors that led to distress, including: (1) financial, (2) transportation, (3) childcare and (4) religious. A total of 916 patients returned distress thermometers. Mean age was 59.1 years. Females comprised 71.3 (653/916) percent of the cohort. On Dunn’s multiple comparison, the following factors were associated with increased distress level: female (p < 0.01), ages 27 to 45 (p < 0.01), uninsured (p < 0.01) and unemployed (p < 0.01). Patients with higher distress scores also experienced worse overall survival (p < 0.05). Females, young patients, uninsured patients and unemployed patients experience more distress after a new cancer diagnosis. Increased distress is independently associated with worse overall survival. Social determinants can be used to predict which patients may require focused interventions to reduce distress after a new cancer diagnosis.
Monolithic 3D integration of back-end compatible 2D material FET on Si FinFET
Authors: Guan Shi-Xian , Yang Tilo H. , Yang Chih-Hao , Hong Chuan-Jie , Liang Bor-Wei , Simbulan Kristan Bryan , Chen Jyun-Hong , Su Chun-Jung , Li Kai-Shin , Zhong Yuan-Liang , Li Lain-Jong , Lan Yann-Wen 
Published: February 2023

AbstractThe performance enhancement of integrated circuits relying on dimension scaling (i.e., following Moore’s Law) is more and more challenging owing to the physical limit of Si materials. Monolithic three-dimensional (M3D) integration has been considered as a powerful scheme to further boost up the system performance. Two-dimensional (2D) materials such as MoS2 are potential building blocks for constructing upper-tier transistors owing to their high mobility, atomic thickness, and back-end-of-line (BEOL) compatible processes. The concept to integrate 2D material-based devices with Si field-effect transistor (FET) is technologically important but the compatibility is yet to be experimentally demonstrated. Here, we successfully integrated an n-type monolayer MoS2 FET on a p-type Si fin-shaped FET with 20 nm fin width via an M3D integration technique to form a complementary inverter. The integration was enabled by deliberately adopting industrially matured techniques, such as chemical mechanical planarization and e-beam evaporation, to ensure its compatibility with the existing 3D integrated circuit process and the semiconductor industry in general. The 2D FET is fabricated using low-temperature sequential processes to avoid the degradation of lower-tier Si devices. The MoS2 n-FETs and Si p-FinFETs display symmetrical transfer characteristics and the resulting 3D complementary metal-oxide-semiconductor inverter show a voltage transfer characteristic with a maximum gain of ~38. This work clearly proves the integration compatibility of 2D materials with Si-based devices, encouraging the further development of monolithic 3D integrated circuits.
Complexin-1 regulated assembly of single neuronal SNARE complex revealed by single-molecule optical tweezers
Authors: Hao Tongrui , Feng Nan , Gong Fan , Yu Yang , Liu Jiaquan , Ren Yu-Xuan 
Published: February 2023

AbstractThe dynamic assembly of the Synaptic-soluble N-ethylmaleimide-sensitive factor Attachment REceptor (SNARE) complex is crucial to understand membrane fusion. Traditional ensemble study meets the challenge to dissect the dynamic assembly of the protein complex. Here, we apply minute force on a tethered protein complex through dual-trap optical tweezers and study the folding dynamics of SNARE complex under mechanical force regulated by complexin-1 (CpxI). We reconstruct the clamp and facilitate functions of CpxI in vitro and identify different interplay mechanism of CpxI fragment binding on the SNARE complex. Specially, while the N-terminal domain (NTD) plays a dominant role of the facilitate function, CTD is mainly related to clamping. And the mixture of 1-83aa and CTD of CpxI can efficiently reconstitute the inhibitory signal identical to that the full-length CpxI functions. Our observation identifies the important chaperone role of the CpxI molecule in the dynamic assembly of SNARE complex under mechanical tension, and elucidates the specific function of each fragment of CpxI molecules in the chaperone process.
Noiseless single-photon isolator at room temperature
Authors: Zhang Shicheng , Zhan Yifan , Gong Shangqing , Niu Yueping 
Published: February 2023

AbstractNonreciprocal devices, such as isolators, are of great importance for optical communication and optical information processing. To bypass the limitation of a strong magnetic field imposed by the traditional Faraday magneto-optic effect, many alternative mechanisms have been proposed to demonstrate magnetic-free nonreciprocity. However, limited by the drive-induced noise, the noiseless isolator capable of working in the quantum regime has yet to be realized in the experiment. Here, we show a noiseless all-optical isolator with genuine single photons in hot atoms. We experimentally study this mechanism using an open V-type level scheme and demonstrate a low insertion loss of 0.6 dB and high isolation of 30.3 dB with bandwidth up to hundreds of megahertz. Furthermore, the nonreciprocal direction can be truly reversed only by tuning the frequency of the pump laser with the same setup. Our scheme relies on widely used optical technology and is thus universal and robust.
Cutoff of transverse waves through the solar transition region
Authors: Pelouze Gabriel , Van Doorsselaere Tom , Karampelas Konstantinos , Riedl Julia M. , Duckenfield Timothy 
Published: February 2023

Context. Transverse oscillations are ubiquitously observed in the solar corona, both in coronal loops and in open magnetic flux tubes. Numerical simulations suggest that their dissipation could heat coronal loops, thus counterbalancing radiative losses. These models rely on a continuous driver at the footpoint of the loops. However, analytical works predict that transverse waves are subject to a cutoff in the transition region. It is thus unclear whether they can reach the corona and indeed heat coronal loops.
Aims. Our aims are to determine how the cutoff of kink waves affects their propagation into the corona and to characterize the variation of the cutoff frequency with altitude.
Methods. Using 3D magnetohydrodynamic simulations, we modelled the propagation of kink waves in a magnetic flux tube, embedded in a realistic atmosphere with thermal conduction, which starts in the chromosphere and extends into the corona. We drove kink waves at four different frequencies and determined whether they experienced a cutoff. We then calculated the altitude at which the waves were cut off and compared it to the prediction of several analytical models.
Results. We show that kink waves indeed experience a cutoff in the transition region, and we identified the analytical model that gives the best predictions. In addition, we show that waves with periods shorter than approximately 500 s can still reach the corona by tunnelling through the transition region with little to no attenuation of their amplitude. This means that such waves can still propagate from the footpoints of loop and result in heating in the corona.