bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inhibition of Interleukin-6 Dependent Metalloproteinases-9/2 Expression
in Cancer Cells by Diet Polyphenols
Authors: Arcone Rosaria , Nasso Rosarita , Pagliara Valentina , D'Errico Antonio , Motti Maria Letizia , D'Angelo Stefania , Carbonara Gabriele , Masullo Mariorosario 
Published: July 2023

Abstract:
Among inflammatory cytokines, Interleukin-6 (IL-6) is one of the major activators of acute phase response and is also involved in immune response and cancer progression. IL-6 is involved in the up-regulation of enzymes and growth factors acting on the extracellular matrix (ECM) remodel-ling components in physio-pathological processes. IL-6 enhances the expression of metalloproteases (MMP-)2/9, enzymes that play a key role in ECM degradation and therefore contribute to the process of tumor metastasis. To counteract and/or prevent cancer diseases, many efforts have been devoted to the identification of factors able to inhibit the IL-6-dependent MMP-9/2 expression. Recently, diet polyphenols have been identified as molecules manifesting anti-inflammatory and anti-cancer proper-ties beyond their well-known capacity to promote health on the basis of their antioxidant effects. This review summarizes the recent advances in this field, focusing on the protective effects exerted by diet polyphenols on the proliferation and invasiveness of tumor cells, with specific emphasis on the ability of these molecules to inhibit the IL-6-dependent upregulation of MMP-2/9.
Preventive effect of Total ethanolic extract of Butea monosperma on bone loss in osteopenic rats
Authors: Khanka Sonu , Lakra Amardeep , Gupta Ritika , Sharma Kriti , Maurya Rakesh , Chattopadhyay Naibedya , Singh Divya 
Published: July 2023

Aim: The intent of the study was to assess the bone conserving effect of Butea monosperma total extract (BTE) prepared from the stem-bark, in ovariectomy (Ovx)-induced bone loss in Sprague Dawley (SD) rats.
Methods: Sprague-Dawley rats were ovariectomized (Ovx) and BTE treatment with three different doses (100mg, 250mg and 500mg/kg body weight) commenced a day after Ovx and continued for 12 weeks. Skeletal parameters including trabecular and cortical bone microarchitecture, bone mineral density, bone mineral content, biomechanical strength, bone turnover markers (serum procollagen 1 N-terminal propeptide/ P1NP and cross-linked C-telopeptide of type I collagen/CTX-1), new bone formation rate (periosteal bone formation rate and mineral apposition rate), and expression of osteogenic genes were assessed. Estrogenicity of BTE was assessed by studying uterus at the end of the treatments.
Results: Ovx rats treated with BTE prevented the alterations in trabecular and cortical microarchitecture, maintained bone mineral density, bone mineral content, and increased bone biomechanical strength in comparison with Ovx rats. Treatment of BTE also enhanced new bone formation rate, increased the serum bone formation marker (P1NP), decreased the serum bone resorption marker (CTX-1), and upregulated the osteogenic genes in bones. BTE was devoid of estrogen-like effect in uterus.
Conclusion: BTE protects against Ovx-induced bone loss by inhibiting bone resorption and increasing new bone formation. The most effective bone conserving dose of BTE was 250mg/kg. This study demonstrates the potential of BTE in preventing/delaying osteoporosis development in postmenopausal women.
Keywords: Butea total extract, ovariectomy, bone formation, bone mineral density.
The Development of Prism and Pyramid Teaching Material Assisted by Construct 2 Software
Authors: Suwangsih Euis , Fitriani Nelly , Sumarmo Utari 
Published: July 2023

The aim of the research is to develop teaching materials assisted by media construct 2 software that are practical and appropriate for use in the learning process. The research method used is Research and Development (R&D) using the ADDIE model. The research was conducted at SMPN 3 RancabaliÂ with 12 class VIII students at Rancabali 3 Middle School for limited trials and 9 students at SMPN 2 Rancabali and 9 students at SMPN 1 Rancabali Public for a wider trial and 27 VIII C class students as an experimental class and 27 class VIII A students as the control class for product trials. The validators consist of ICT experts, subject matter experts and teachers. The data collection technique was in the form of a response questionnaire from students and teachers. The research results of the products developed were in accordance with the ADDIE research method with product feasibility categories based on ICT expert validation of 81.25%, material experts 85% and teachers 88% are all included in the very decent category. Products that have been validated are then tested on students through limited trials, wider trials and product trials and students are given practicality questionnaires with a final average result of 83.56% included in the very practical category. Based on the validation results of ICT experts, material experts and student and teacher responses, it was concluded that the teaching materials assisted by the media construct 2 software are valid and appropriate for use in learning. For further research, the researcher hopes to be able to develop teaching materials better according to the suggestions from the respondents.
Perspektywy zmian na rynku pracy w powiecie siedleckim w opinii pracodawców
Authors: Soczewka Iwona , Kałuża Halina 
Published: July 2023

Podstawowym celem pracy było dokonanie analizy zmian, jakie nastąpią do 2015 r. na rynku pracy w powiecie siedleckim w opinii pracodawców z tego regionu. Badania zostały przeprowadzone w 2010 r. w losowo wybranych przedsiębiorstwach o różnym poziomie zatrudnienia. Na podstawie przeprowadzonych badań stwierdzono, iż w przyszłości najbardziej pożądani na tym rynku będą pracownicy sfery usługowej, obejmującej zarówno usługi osobiste, jak i związane z obsługą biznesu (np. usługi bankowe i ubezpieczenia). Będzie to wymagać zwiększenia dotychczasowej podaży zawodów wykorzystywanych w tej sferze gospodarki, a zwłaszcza wprowadzania na rynek pracy absolwentów szkół zawodowych zdolnych do świadczenia nowych typów usług.
<strong>Bariatric surgery alters the postprandial recovery from hypoglycemia mediated by cholinergic signal </strong>
Authors: Salehi Marzieh , Tripathy Devjit , Peterson Richard , Honka Henri , Pezzica Samantha , DeFronzo Ralph , Gastaldelli Amalia 
Published: July 2023

<p> </p>
<p>Roux-en-Y gastric bypass surgery (GB) and sleeve gastrectomy (SG) increase prandial insulin and glucagon secretion but reduce the endogenous glucose production (EGP) response to hypoglycemia compared to non-operated controls (CN), suggesting that parasympathetic nervous system (PNS) plays a role. Here, we investigated the effect of acute PNS blockade on the post-meal counterregulatory response to insulin-induced hypoglycemia in GB and SG compared to CN. Glucose kinetics and islet-cell secretion were measured in 9 non-diabetic subjects with GB, 7 with SG, and 5 CN during hyperinsulinemic hypoglycemic clamp (~3.2mM) combined with meal ingestion on two separate days with and without intravenous atropine infusion. Glucose and hormonal levels were similar at baseline and during steady state hypoglycemia before meal ingestion in 3 groups and unaffected by atropine. Atropine infusion diminished prandial systemic appearance of ingested glucose (<em>RaO</em>) by 30%, <em>EGP</em> by 40%, and glucagon response to hypoglycemia by 90%, in controls. In GB or SG, blocking PNS had no effect on the <em>RaO</em> or meal-induced hyperglucagonemia, but increased <em>EGP</em> in SG without any effect in GB (p<0.05 interaction). These findings indicate that cholinergic signal contributes to the recovery from hypoglycemia by meal consumption in humans. However, bariatric surgery dissipates PNS-mediated physiologic responses to hypoglycemia in the fed state. </p>
Código de ética empresarial, un análisis del aporte de los profesionales y la percepción de los empleados sobre su importancia en las empresas
Authors: Sabido-Domínguez Teresita de Jesús , Alonso-Novelo Valentín , Barredo-Baqueiro Gustavo Alberto 
Published: July 2023

Debido a los escándalos financieros presentes desde hace décadas, las empresas buscan mayores controles que apoyen el debido cumplimiento de todo tipo de actividades que realizan con diversos agentes con los que trabaja. Un control es establecer un Código de ética empresarial. El propósito de este trabajo fue identificar la percepción que tienen los estudiantes-empleados de empresas de Mérida, México, con respecto a las nociones de ética empresarial en el desarrollo de sus actividades en donde trabajan.
Se obtuvo información de fuentes primarias, al utilizar una encuesta con muestreo no probabilístico por conveniencia. Los resultados indican que, en las pymes, los empleados consideren de importancia el establecimiento de un Código de Ética. La mayoría de los encuestados define la ética como “la buena actuación profesional” (65.56%), seguido por “Buen sentido común” (31.48%). Los encuestados consideran que “los valores éticos en la empresa les ayudan a:” guiar acciones (47.04%), a ser mejores personas (30.00%), a progresar (20.37%) o a cumplir requisitos (2.59%). Los resultados obtenidos indican que en un 51.11% de las empresas no existe un código de ética, sin embargo, el 71.85% de los encuestados indicó que se establece un compromiso de comportamiento ético como trabajador de la empresa cuando lo deseable sería la formalización de estos compromisos por medio de códigos. Quienes contestaron consideran que la información adecuada, oportuna y periódica sobre el cumplimiento de reglas, objetivos y metas en su empresa es, con un 95%, de importancia de conocer para poder contribuir en sus logros.
General Architecture of Sustainable Urban Spatial Development Model Based on Smart Cities
Authors: Ma Xiaolei 
Published: July 2023

Abstract
With the rapid growth of China’s national economy and urbanization, the use of urban space in China has developed greatly. At the same time, there are also many problems, the relationship between urban space planning and ground planning is not coordinated enough, and there are certain contradictions in the development of different levels of space, which will inevitably affect the sustainable development of urban space in China in the long run. The fuzzy comprehensive evaluation method is adopted as the evaluation method for the sustainability of urban space development. Firstly, the AHP method is applied to determine the weights of each specific indicator in the index layer. The sustainability of the current status of underground space development reflected by each indicator is determined by the expert scoring method. Finally, the evaluation results of “sustainable urban spatial development” were obtained using the spatial sustainability model for the example of the cities. In summary, the sustainable urban spatial development model based on smart cities can reflect the development status, development trend, and coordination with the comprehensive external environment of urban space in a comprehensive manner, and can measure and evaluate the degree of sustainable development, thus helping to identify problems that limit sustainable development.
Analysis of the practical education model and its value in the context of big data in university civic education
Authors: Wei Senjie 
Published: July 2023

Abstract
In order to verify the feasibility of data mining for the practical education model and its value analysis of college civic education in the context of big data. Based on the big data mining algorithm-parallel density clustering algorithm, this paper designs five types of teaching evaluation indexes of Civic Education as experiments to explore the new direction of Civic Education practice in colleges and universities in terms of value perception and target, teaching content, and method, teaching interaction, and organization, learning input and support, and learning effectiveness and evaluation. The experimental indexes show that: through the big data mining algorithm, we can understand that the current students have relatively good feelings towards “Civic Education” and “Introduction” courses, with mean values of 4.03 and 4.01, respectively; they prefer current issues in teaching contents and methods, with mean values of 7.48; they prefer current issues in teaching contents and methods. The mean value is 7.48; the mean value is 5.45; the mean value is 5.12; the mean value is 5.12; the mean value is 6.85; the mean value is 6.85; the mean value is 6.85. The results also show that the big data parallel density clustering algorithm can provide the relevant data mining analysis for the college Civic Education practice. The results also show that the big data parallel density clustering algorithm can provide relevant mining data analysis for college thinking and political education practice and can present the innovative reform direction of college thinking and political education through data more intuitively. It also makes the college thinking education truly enjoy the dividends of the big data era.
Fuzzy PID control theory in multi-objective optimal longitudinal following of intelligent trolley
Authors: Sun Yanping 
Published: July 2023

Abstract
As a kind of mobile robot, the intelligent trolley is also called a wheeled robot, and this field is the fastest growing in the current technological development. Smart trolleys have good automatic guidance functions, often used in modern logistics conveying systems. A fuzzy control algorithm has a good control effect for nonlinear systems and has a strong anti-interference ability. In order to optimize the multi-objective longitudinal following system of smart carts, therefore, this paper develops the study of fuzzy PID control algorithm for multi-objective longitudinal following of smart carts. Based on the incremental PID control, an improved PID algorithm is constructed by introducing incomplete differentiation, differential prior, and “optimal curvature” algorithm. Based on the actual control experience, the fuzzy control table is designed, and the adaptive control algorithm is obtained. Finally, the simulation results of the fuzzy PID control algorithm are tested by MATLAB/Simulink, and the most suitable fuzzy PID control algorithm for multi-objective optimal longitudinal following of intelligent carts is derived.
Design and research of big data technology based on e-commerce platform
Authors: Dai Liwu 
Published: July 2023

Abstract
In this paper, we study the access technology and cluster analysis of review data in the era of big data. We combine the nutch web crawler and Hadoop distributed to crawl evaluation data through distribution and solve the problem of slow execution of a single machine; After some filtering and extracting feature words, the TF-IDF calculation method is used to calculate the weight of feature words to facilitate the construction of text vectorization representation. Finally, the similarity between statements is calculated based on the VSM method. Then, the distributed operation of the canopy algorithm and K-means algorithm is realized by combining the map-reduce framework, which greatly speeds up the efficiency and accuracy of clustering. Finally, taking the comment data of a brand water purifier as an example, this paper crawls out the comment data of the product from the e-commerce platform and carries out cluster analysis. After integrating the statistics, it can be seen from the figure that the processing time gradually increases with the increase in the number of comments. And increases in the form of a power function. Compared with 6217 comments, the processing time of 10858 comments increased by about 13%. 21083 comments increased by 36%. 31947 comments increased by 61%. 52944 comments increased by 96% 83168 comments increased by 145%.
Gandhi and Student Politics.docx
Authors: saurabh amit 
Published: July 2023

<p> </p>
<p>This article focuses on the question of student politics in contemporary India using the ideas of Mahatma Gandhi and Bhagat Singh around the concept of student and student politics. Generally, the ideas of Mahatma Gandhi are read in contrast with the ideas of revolutionaries like Bhagat Singh, but student politics is one such area where we witness a kind of similarity between both personalities therefore this article is an attempt to explore this. While reflecting on the subject undertaken, this article also attempts to problematize the nature of student politics in current India. </p>
Les usages du « modèle canadien » dans la presse francophone
Authors: Premat Christophe 
Published: July 2023

L’expression « modèle canadien » est souvent employée dans le discours journalistique car elle reflète une volonté de comparaison des institutions sociales. Pour la presse francophone, l’enjeu est de savoir si cette formule cache un jeu d’énonciations dans lequel le Canada représente un exemple à imiter ou au contraire à éviter. Afin de pouvoir apprécier la portée de cet énoncé normatif ayant des conséquences dans l’espace des marques nation, l’article s’appuie sur l’analyse longitudinale de deux corpus francophones permettant de repérer la fréquence d’utilisation de cette formule ainsi que les énoncés remarquables. Les résultats montrent que cette expression abrite la distinction d’avec le modèle américain mais aussi d’avec le modèle québécois. La presse française perçoit ce « modèle canadien » comme une portée d’entrée euphémisant la société de marché américaine, mais aussi comme le symbole d’un contrat multiculturel en opposition à la pensée républicaine française fondée sur un modèle unitaire à vocation universaliste.
Seller Financing: Contracting Out of the Lemons and Moral Hazard Problems When They May Co-Exist
Authors: Tirtiroglu Dogan , Tirtiroglu Ercan 
Published: July 2023

<p>Quality problems that are known to the seller of an asset, but will become known to the buyer only after the purchase have the potential to frustrate voluntary exchanges. When the problem is subtle or confounded by the extent of buyer inputs, requiring risk-sharing by the contracting parties, both parties would benefit from a mechanism, such as seller financing, which not only credibly signals to the buyer the veracity of the seller’s representations about the asset (s)he is trying to sell, but also offers the seller sufficient protections against the potential that the buyer may engage in post-sale opportunistic behavior about the maintenance of the asset. We analyze one-time-only mortgage contracts in the National Association of Realtors' Home Financing Transaction database for 1984-1996, (data not collected outside this period), and find empirical support for seller financing as an asset quality signal and, separably, as a mechanism for providing credit when conventional credit sources are tight. We also point out the broad, but not well-acknowledged, reach of seller financing, including the sub-prime loan debacle, the earnout mergers or reverse annuity mortgages, which are inherently embedded with both asymmetric information about the quality of the relevant assets and moral hazard about the asset acquirer’s post-purchase maintenance.</p>
<p> </p>
Incidence disparities of obstructive sleep apnea-associated lung cancer by gender; Korean National Health Insurance data analysis
Authors: Park Marn Joon , Han Kyung-Do , Cho Jae Hoon , Choi Ji Ho 
Published: July 2023

IntroductionObstructive sleep apnea (OSA) is known to increase the risk of various cancers. By analyzing the Korea National Health Insurance Service (KNHIS) registry, the impact of OSA on the lung cancer incidence was analyzed in a retrospective cohort group.MethodsA retrospective cohort of adult patients newly registered with OSA in the KNHIS data from 2007 to 2017 was included and observed until December 2019 (12 years). The main outcome measure was newly diagnosed lung cancer. The control group was set with age and sex that matched those in the OSA group.ResultsThe hazard ratio (HR) of OSA for lung cancer incidence showed a significantly reduced HR of 0.87 (95% CI, 0.82–0.93). The observed significance of this finding was limited to male OSA patients [HR, 0.84 (95% CI, 0.78–0.90)], while no significant association was found in female OSA patients [HR, 1.05 (95% CI, 0.91–1.21)], irrespective of their age.DiscussionOSA patients have a lower risk of developing lung cancer, but this risk reduction is gender-specific, as female OSA patients do not show a reduction in hazard ratio.
Mortalidade por Diabetes Mellitus no nordeste do Brasil no período de 2014 a 2018
Authors: Negreiros Erika Cristina Moura da Silva , Silva Laiany Caroline dos Santos , E Araujo Ana Carolina Ribeiro de Araujo , Dias Laura Rosa Carvalho , De Moura Luís Victor Moraes , Rosa Isabella Mota Santa , De Menezes Filho José Mário , Marques Consuelo Penha Castro 
Published: July 2023

O Diabetes Mellitus (DM) é um grupo de distúrbios metabólicos marcado pela hiperglicemia, e classifica-se em diversos subtipos. Atualmente é grande desafio para os sistemas de saúde do mundo, com aumento progressivo de impacto devido à urbanização e industrialização, por consequência de hábitos de vida não saudáveis. Esta desordem metabólica encontra-se dentre os cincos principais riscos para mortalidade no mundo, podendo desencadear complicações agudas ou crônicas no sistema cardiovascular, renal e neurológico, geralmente com alterações funcionais em órgãos, especificamente, coração, rins, encéfalo e vasos sanguíneos no geral. Este estudo teve o objetivo de analisar a mortalidade por Diabetes Mellitus na Região Nordeste brasileira entre os anos de 2014 a 2018, através de estudo epidemiológico de série temporal, com dados secundários DATASUS- Ministério da Saúde, com pesquisa das variáveis: sexo, raça, escolaridade, faixa etária, estado civil, local de ocorrência, Nordeste, categoria CID-10, diabetes. Os dados foram expressos em números absolutos, percentuais e estatística descritiva. Foram encontrados 101.636 casos, sendo 56% do sexo feminino e maior número, respectivamente, nos estados Bahia e Pernambuco. A maioria dos óbitos está concentrada na categoria diabetes mellitus não especificada, seguido da categoria não insulino-dependente e insulinodependente. Quanto à escolaridade, 35% dos óbitos estão na categoria nenhuma escoloridade e 23% com 1 a 3 anos de estudo. No quesito faixa etária, observa-se maioria de óbitos a partir de 80 anos, com progressão da quantidade à medida que aumenta a faixa etária. Encontra-se prevalência de 58% dos óbitos na raça parda, seguido por raça branca e preta, respectivamente. Os óbitos ocorreram em sua maioria em pessoas casadas, sendo 39% dos casos, seguido de viúvos, 29%, e solteiros 24%. O local de ocorrência mais registrado foi no hospital, com 63% dos óbitos e 31% em outro estabelecimento de saúde. O perfil epidemiológico traçado aponta a necessidade de articulação de estratégias regionalizadas e peculiares, com promoção e educação em saúde, objetivando melhor manejo do DM e diminuição das taxas de mortalidade, principalmente as de faixas etárias precoces.