bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of Ving Tsun sticking-hand training on lower limb sensorimotor performance among community-dwelling middle-aged and older adults: a randomized controlled trial
Authors: Fong Shirley S. M. , Chung Louisa M. Y. , Yam Timothy T. T. , Chung Joanne W. Y. , Bae Young-Hyeon , Gao Yang , Chan Jessie S. M. , Wang Hsing-Kuo 
Published: February 2023

Abstract
Background
To explore the effects of Ving Tsun (VT) sticking-hand training on knee joint proprioception and leg muscular performance among community-dwelling middle-aged and older adults.

Methods
Thirty-three middle-aged and older adults were randomly assigned to either the VT or control group. The VT group received sticking-hand training twice/week for 3 months. Data were collected before and after the intervention period. The primary outcome was knee joint repositioning error, which was measured using knee joint active repositioning tests. The secondary outcomes included the maximum muscle strength and time to maximum muscle strength of the major leg muscles.

Results
No significant group, time, or group-by-time interaction effects were found for the knee joint repositioning error (p > 0.05). The maximum muscle strength of the knee flexors increased over time in the VT group only (p = 0.038). In addition, the time to maximum muscle strength in the hip extensors and flexors increased over time in both groups (p < 0.05). For the knee extensors and flexors, the time to maximum muscle strength increased in the control (p = 0.027) and VT (p = 0.019) groups, respectively, over time.

Conclusions
VT sticking-hand training could improve the maximum muscle strength of the knee flexors but could not attenuate the age-related deterioration in leg muscle contraction speed nor improve knee joint proprioception among community-dwelling middle-aged and older adults.

Trial registration
ClinicalTrials.gov NCT03318289. Registered on 23 October 2017.
Efficiency of probiotics in elderly patients undergoing orthopedic surgery for postoperative cognitive dysfunction: a study protocol for a multicenter, randomized controlled trial
Authors: Zhang Xiaoyi , Chen Yuwen , Tang Ying , Zhang Yizhe , Zhang Xiao , Su Diansan 
Published: February 2023

Abstract

Background
Postoperative cognitive dysfunction (POCD) refers to a neurological dysfunction after a major surgery and anesthesia. It is common in elderly patients and is characterized by impairment in consciousness, orientation, thinking, memory, and executive function after surgical anesthesia. However, at present, there is no definite preventive or treatable strategy for it. Previous animal experiments showed that giving probiotics to mice before operation can prevent POCD, but there is a lack of clinical evidence. This study aims to intervene with the intestinal flora imbalance using probiotics during the perioperative period to reduce the incidence of POCD in elderly patients after orthopedic surgery and to provide new ideas and methods for the clinical prevention and treatment of POCD.

Methods
A multicenter, double-blind, placebo-controlled clinical trial will be performed to evaluate the efficacy of probiotics in elderly patients undergoing orthopedic surgery. Participants (n = 220) will receive probiotics (Peifeikang, Live Combined Bifidobacterium, 210 mg per capsule, twice a day, four capsules each time, which contains Bifidobacterium longum, Lactobacillus acidophilus and Streptococcus faecalis no less than 1.0 × 107 CFU viable bacteria respectively) or placebo from 1 day before surgery to 6 days after surgery. Neuropsychological tests will be performed 1 day before surgery and 1 week and 1 month after surgery. The main outcome of this study is the incidence of POCD 7 days after surgery. Our secondary objective is to assess the incidence of POCD 1 month after surgery; the cognitive status will be determined based on a telephone interview and will be evaluated via TICS-m; postoperative delirium will be assessed 7 days after surgery using the Confusion Assessment Method (CAM).

Discussion
Discovering the correlation between the intestinal microbiota and POCD is an important breakthrough. Based on the key role of the intestinal microbiota in other cognitive disorders, we hope that probiotics can reduce its incidence in elderly orthopedic patients.

Trial registration
ClinicalTrials.gov NCT04017403. Registered on August 15, 2019.
Esketamine combined with pregabalin on acute postoperative pain in patients undergoing resection of spinal neoplasms: study protocol for a randomized controlled trial
Authors: Sun Wanchen , Wang Juan , Wang Jing , Fan Jingyi , Zhou Yang , Wang Yunzhen , Han Ruquan 
Published: February 2023

Abstract
Background
Perioperative pain management is one of the most challenging issues for patients with spinal neoplasms. Inadequate postoperative analgesia usually leads to severe postsurgical pain, which could cause patients to suffer from many other related complications. Meanwhile, there is no appropriate analgesic strategy for patients with spinal neoplasms.

Methods/design
This is a protocol for a randomized double-blind controlled trial to evaluate the effect of esketamine combined with pregabalin on postsurgical pain in spinal surgery. Patients aged 18 to 65 years scheduled for spinal neoplasm resection will be randomly allocated into the combined and control groups in a 1:1 ratio. In the combined group, esketamine will be given during the during the surgery procedure until 48-h postoperative period, and pregabalin will be taken from 2 h before the surgery to 2 weeks postoperatively. The control group will receive normal saline and placebo capsules at the same time points. Both groups received a background analgesic regimen by using patient-controlled intravenous analgesia (containing 100 μg sufentanil and 16 mg ondansetron) until 2 days after surgery. To ensure the accuracy and reliability of this trial, all the researchers and patients will be blinded until the completion of this study. The primary outcome will be the proportion of patients with acute moderate-to-severe postsurgical pain (visual analog scale, VAS ≥ 40, range: 0–100, with 0, no pain; 100, the worst pain) during the 48-h postoperative period. The secondary outcomes will include the maximal VAS scores (when the patients felt the most intense pain over the last 24 h before being interviewed) at 0–2 h, 2–24 h, 24–48 h, and 48–72 h after leaving the operating room and 24 h before discharge; the incidence of acute moderate-to-severe postsurgical pain at each other time point; chronic postsurgical pain assessment; neuropathic pain assessment; and the incidence of drug-related adverse events and other postoperative complications, such as postoperative delirium and postoperative nausea and vomiting (PONV).

Discussion
The aim of this study was to evaluate the effect of esketamine combined with pregabalin on acute postsurgical pain in patients undergoing resection of spinal neoplasms. The safety of this perioperative pain management strategy will also be examined.

Trial registration
ClinicalTrials.gov NCT05096468. Registered on October 27, 2021
Microsatellite profiling of hosts from parasite-extracted DNA illustrated with raccoons (Procyon lotor) and their Baylisascaris procyonis roundworms
Authors: Frantz Alain C. , Lippert Stéphanie , Heddergott Mike 
Published: February 2023

Abstract
Background
Important information on movement pathways and introduction routes of invasive parasites can be obtained by comparing the genetic makeup of an invader with its spatial genetic structure in other distribution areas. Sometimes, the population genetic structure of the host might be more informative than that of the parasite itself, and it is important to collect tissue samples of both host and parasite. However, host tissue samples are frequently not available for analysis. We aimed to test whether it is possible to generate reliable microsatellite profiles of host individuals by amplifying DNA extracted from a nematode parasite, using the raccoon (Procyon lotor) and the raccoon roundworm (Baylisascaris procyonis) as a test case.

Methods
Between 2020 and 2021, we collected tissue as well as a single roundworm each from 12 raccoons from central Germany. Both the raccoon and the roundworm DNA extracts were genotyped using 17 raccoon-specific microsatellite loci. For each roundworm DNA extract, we performed at least eight amplification reactions per microsatellite locus.

Results
We extracted amplifiable raccoon DNA from all 12 roundworms. We obtained at least two amplification products for 186 of the 204 possible genotypes. Altogether 1077 of the 1106 genotypes (97.4%) matched the host-DNA derived reference genotypes and thus did not contain genotyping errors. Nine of the 12 roundworm-derived genetic profiles matched the reference profiles from the raccoon hosts, with one additional genetic profile containing genotyping errors at a single locus. The remaining two genetic profiles were deemed unsuitable for downstream analysis because of genotyping errors and/or a high proportion of missing data.

Conclusions
We showed that reliable microsatellite-based genetic profiles of host individuals can be obtained by amplifying DNA extracted from a parasitic nematode. Specifically, the approach can be applied to reconstruct invasion pathways of roundworms when samples of the raccoon hosts are lacking. Further research should assess whether this method can be replicated in smaller species of parasitic nematodes and other phyla of parasites more generally.

Graphical Abstract
The high-intensity interval training (HIIT) and curcumin supplementation can positively regulate the autophagy pathway in myocardial cells of STZ-induced diabetic rats
Authors: Sadeghi Samira , Delphan Maryam , Shams Masoumeh , Esmaeili Fataneh , Shanaki-Bavarsad Mahsa , Shanaki Mehrnoosh 
Published: February 2023

Abstract
Objective
Targeting autophagy is a new therapeutic strategy for the complications of diabetes,such as diabetic cardiomyopathy (DCM). During diabetes, increased or insufficient autophagic activity causes aberrations in cellular homeostasis. Regarding the conflicting and unclear results regarding the effect of HIIT and curcumin supplementation on the expression of genes associated to autophagy, this study aimed to assess whether 4-week high-intensity interval training (HIIT) and curcumin supplementation are able to influence the expression of autophagy-related genes in myocardial cells of diabetic rats.

Methods
In an experimental design, 24 male Wistar rats were randomly divided into 4 groups: non-diabetic control (NC), diabetic control (DC), diabetes + HIIT (D + HIIT), and diabetes + curcumin (D + CU). After HIIT program and curcumin treatment, the genes expression of autophagy pathway were assessed in the myocardium by real-time PCR Tanique.

Results
The results indicated that the expression levels of ATG1, Beclin1, ATG5, and LAMP-2 genes were significantly reduced in the DC group compared to the NC group (p < 0.001). Following 4-week HIIT, the expression of Beclin1, ATG-5, and LAMP-2 improved considerably compared to the DC group (p < 0.001, p < 0.001, and p < 0.05, respectively). In addition, after 4 weeks of curcumin supplementation, the expression levels of ATG-5 and Beclin-1 were significantly improved compared to the DC group (p < 0.001, p < 0.05, respectively). It seems HIIT and curcumin supplementation can be an effective approach for inducing autophagy and improving cardiac function in DCM rats.However, HIIT seems more effective than curcumin in this regard.
Physicochemical and nanomedicine applications of phyto-reduced erbium oxide (Er2O3) nanoparticles
Authors: Mohamed Hamza Elsayed Ahmad , Khalil Ali Talha , Hkiri Khaoula , Ayaz Muhammad , Abbasi Jamil Anwar , Sadiq Abdul , Ullah Farhat , Nawaz Asif , Ullah Ikram , Maaza Malik 
Published: February 2023

AbstractHyphaene thebaica fruits were used for the fabrication of spherical erbium oxide nanoparticles (HT-Er2O3 NPS) using a one-step simple bioreduction process. XRD pattern revealed a highly crystalline and pure phase with crystallite size of ~ 7.5 nm, whereas, the W–H plot revealed crystallite size of 11 nm. FTIR spectra revealed characteristic Er-O atomic vibrations in the fingerprint region. Bandgap was obtained as 5.25 eV using K-M function. The physicochemical and morphological nature was established using Raman spectroscopy, reflectance spectroscopy, SAED and HR-TEM. HT-Er2O3 NPS were further evaluated for antidiabetic potential in mice using in-vivo and in-vitro bioassays. The synthesized HT-Er2O3 NPS were screened for in vitro anti-diabetic potentials against α-glucosidase enzyme and α-amylase enzyme and their antioxidant potential was evaluated using DPPH free radical assay. A dose dependent inhibition was obtained against α-glucosidase (IC50 12 μg/mL) and α-amylase (IC50 78 μg/mL) while good DPPH free radical scavenging potential (IC50 78 μg mL−1) is reported. At 1000 μg/mL, the HT-Er2O3 NPS revealed 90.30% and 92.30% inhibition of α-amylase and α-glucosidase enzymes. HT-Er2O3 NPs treated groups were observed to have better glycemic control in diabetic animals (503.66 ± 5.92*** on day 0 and 185.66 ± 2.60*** on day 21) when compared with positive control glibenclamide treated group. Further, HT-Er2O3 NPS therapy for 21 days caused a considerable effect on serum total lipids, cholesterol, triglycerides, HDL and LDL as compared to untreated diabetic group. In conclusion, our preliminary findings on HT-Er2O3 NPS revealed considerable antidiabetic potential and thus can be an effective candidate for controlling the post-prandial hyperglycemia. However, further studies are encouraged especially taking into consideration the toxicity aspects of the nanomaterial.
From brick-and-mortar to livestream shopping: product information acquisition from the uncertainty reduction perspective
Authors: Hwang Joohye , Youn Song-yi 
Published: February 2023

AbstractThis study investigates how livestream fashion shopping is associated with brick-and-mortar shopping, focusing on product uncertainty, and examines livestreaming’s role in reducing product uncertainty and promoting consumers’ purchase intention by adopting the Uncertainty reduction theory (URT). The study identifies the three product information sources (i.e., product demonstration, interaction with the seller, and other viewers’ reviews) that consumers use in livestream shopping via uncertainty-reducing strategies. PLS results (n = 292) indicate that consumers who rely on salespeople’s assistance as a product information source in brick-and-mortar shopping showed a positive perception of the two product information sources—interaction with the seller and other viewers’ reviews—in livestream shopping. The seller’s product demonstration played a significant role in reducing product uncertainty and subsequently affected purchase intention, while the other two information sources (i.e., interaction with the seller and other viewers’ reviews) affected the purchase intention directly. The findings extend the URT to improve our understanding of consumer information attainment in the livestream shopping context and exemplify a promising future for livestream fashion shopping by investigating its features that can potentially substitute for the brick-and-mortar shopping experience. Future studies can include motivational factors (i.e., service and/or technical barriers) in the model.
Impact of CO2 emission on life expectancy in India: an autoregressive distributive lag (ARDL) bound test approach
Authors: Das Sujoy , Debanth Avijit 
Published: February 2023

AbstractAs a developing country, one of the important objectives of India is to accelerate economic growth. This has a considerable impact on CO2emission. Life expectancy has a probable connection with CO2emission in two opposite ways. Given technological status, more CO2emission consequents upon more production of output and higher income level which is likely to affect the life expectancy of people in a positive way. Conversely, CO2emission is one of the important air pollutants that may reduce the span of human life. This paper aims to investigate the net impact of CO2on life expectancy in India. Furthermore, the study seeks to search whether India has surpassed the optimal limit of CO2emission in relation to life expectancy. Using World Bank time series data for the period 1991–2018 and applying ARDL cointegration technique, the study concludes the existence of a long-run and quadratic relationship between life expectancy and CO2emission. The study finds that India has already surpassed its optimal atmospheric concentration of CO2and thereby suggests adopting CO2reduction strategies.
Congenital anterior urethral diverticulum in children: case series and review of the literature
Authors: Piplani Rajat , Acharya Samir K. , Bagga Deepak 
Published: February 2023

Abstract
Background
Congenital anterior urethral diverticulum (CAUD) is a rare condition in children. This condition can present at any age; however, it is more commonly identified in infants and older children. The patient may present with difficulty in micturition, dribbling of urine, poor urinary stream, or urinary tract infection. Children with large anterior urethral diverticulum with poor spongiosal support may also complain of cystic ventral penile swelling during micturition.

Methods
In this series, we report seven such cases of congenital anterior urethral diverticulum treated over a period of 12 years (2008–2020). All cases presented to the Pediatric Surgery Department with dysuria, dribbling of urine, recurrent urinary tract infection, and/or fluctuant ventral penile swelling. They were further evaluated with retrograde urethrography with micturating cysto-urethrogram and cysto-urethroscopy.

Results
Three cases had anterior urethral valves that were managed by cystoscopic fulguration of valves. Surprisingly, all these three cases had concomitant posterior urethral valves, while the other four cases presented with relatively larger and saccular anterior urethral diverticulum required excision of the diverticulum and primary urethral reconstruction.

Conclusions
The cases with congenital anterior urethral diverticulum secondary to anterior urethral valves may also be associated with posterior urethral valves as seen in our case series. Surgeons should be aware of this association, and both valves should be fulgurated in the same sitting. A larger and saccular anterior urethral diverticulum requires excision and urethroplasty as a definitive procedure.
Age-Dependent and Body Composition–Dependent Association of Child Gut Microbial Enterotype With Puberty Timing: A Chinese Cohort
Authors: Xu Yujie , Xiong Jingyuan , Shan Shufang , Wang Xiaoyu , He Fang , Cheng Guo 
Published: February 2023

Abstract

Context
Puberty timing, which is vital for adult well-being, has recently been suggested to be linked to specific gut taxa. However, the impact of comprehensive gut microbiome structure assessed by enterotype on puberty timing remains unknown.

Objective
Investigate the prospective association of gut microbial enterotype with puberty timing and the potential interaction of age and body composition.

Methods
This study included 1826 children from the Chinese Adolescent Cohort Study, a cohort that has collected information on sociodemographics, dietary intake, physical activity, anthropometry, and pubertal development of children aged 6-8 years since 2013 and follows them up annually until the age of 15 years. Fecal samples have been collected annually since 2019 and analyzed for 16S rRNA sequencing and targeted fecal metabolomics. Cox proportional hazard regression models were used to investigate the prospective association of enterotype with puberty timing and the impact of age and body mass index (BMI) sex- and age-independent standard deviation score (SDS).

Results
592 (32.4%) and 1234 (67.6%) children belonged to the Prevotella-rich enterotype and the Bacteroides-rich enterotype, respectively. Children with the Bacteroides-rich enterotype experienced their menarche/voice break later than those with the Prevotella enterotype (hazard ratio 0.53, 95% CI 0.28-0.98), P = .02). Moreover, this association was more pronounced among younger children with higher BMI SDS (P for interaction = .006).

Conclusion
Our findings supported a role for gut microbial communities in pubertal development, in which younger children with higher body mass seems more sensitive.
Leadership in public administration: today's challenges
Authors: Shorobura I. , Dolynska O. 
Published: February 2023

The participation of the public in the formation and implementation of the state policy of promoting the development of civil society by the executive authorities is ensured. The issue of leadership in public administration is extremely relevant today. Leadership is the object of research by many scientists, three main theoretical approaches to understanding leadership (charismatic action, situational theory, synthetic theory) have been formulated. Leadership is a type of activity that permeates the entire management system. It is impossible to effectively perform the functions of planning, organization, motivation and control if there is no effective management and leaders.
The manager’s personality is formed gradually. In psychology, various approaches to the development of theoretical models of personality development and the effectiveness of managerial activities of managers have been developed (collective approach, competitive, partial, engineering-psychological approach, reflective value approach, social-psychological, situational-complex approach, factor approach, functional approach, image approach, integrative).
Seven skills and character traits of a manager valuable to companies are highlighted: leadership skills, strategic thinking, technical and technological skills, the ability to build relationships and create a team, the ability to present oneself and communicate, change management, honesty.
The practice of training and retraining of managers includes active learning methods. The problem of the manager's culture in management philosophy is gaining importance. The main scientific disciplines are highlighted.
Today, there are a significant number of grand programs for leaders of public administration that contribute to the development of leadership qualities.
Self-management is the ability to manage oneself, one's potential, abilities, and knowledge.
The working hours of the majority are condensed. The only solution can be the use of special techniques and methods, which have the general name of time management. There are many methods for solving problems related to the rational use of working time. The main principles of time management are highlighted.