bluuebunny/crossref_metadata_2025_split huggingface dataset:
1,3,5‐Triformylphloroglucinol Derived β‐Ketoenamine‐Linked Functional Covalent Organic Frameworks with Enhanced Crystallinity and Stability–Recent Advances
Authors: Rajasekharan Sujatha Athira , Anil Aparna , Deni Raju Princy , Veettil Suneesh Chettiyam 
Published: January 2025

AbstractCrystallinity, stability, and complexity are significant factors to consider in the design and development of covalent organic frameworks (COFs). Among various building blocks used, 1,3,5‐triformylphloroglucinol (Tp) is notable for enhancing both crystallinity and structural stability in COFs. Tp facilitates the formation of β‐ketoenamine‐linked COFs through keto‐enol tautomerism when reacted with aromatic amines. This review article examines the stability, crystallinity, and flexibility of synthetic methodologies involving Tp‐based COFs, while highlighting their recent applications. We emphasize the critical roles of non‐covalent interactions and keto‐enol tautomerism in achieving high levels of crystallinity and stability. Additionally, the diverse and straightforward synthesis methods available for Tp‐based COFs contribute to the prevalence of 1,3,5‐triformylphloroglucinol in COF development. We conclude by addressing the challenges and future prospects in this area, underscoring the significant potential of Tp‐based COFs for environmental and energy‐related applications due to their exceptional structural tunability and functionality.
Tailoring Förster Resonance Energy Transfer in Copper Nanoclusters‐Polymer Nanoparticles Composites through Ligands
Authors: Rashi  , Ghosh Srijon , Devi Aarti , Patra Amitava 
Published: January 2025

AbstractAtomically precise metal nanoclusters (MNCs) represent an emerging class of nanomaterials for light harvesting materials. Here, we synthesized Cu₉ nanoclusters (NCs) with cysteine (CYS) and reduced glutathione (GSH) ligands, along with poly(N‐vinyl carbazole) (PVK) nanoparticles (PNPs). Nanocomposites of Cu₉ NCs with PVK PNPs via electrostatic attachment have been designed to investigate their energy transfer process. A significant overlap of their absorption spectra with the emission of PVK and the absorption band of Cu NCs facilitated the Förster resonance energy transfer (FRET) from PVK PNPs to the Cu NCs. Steady‐state and time‐resolved spectroscopic studies confirm the FRET dynamics, and parameters, such as energy transfer efficiency, donor‐acceptor distance, rate constants, and the antennae effect were calculated. Our results revealed that Cu CYS/PVK PNP nanocomposite exhibited a higher energy transfer efficiency (77 %), faster energy transfer rate, and higher antennae effect than the Cu GSH/PVK PNP system. This was attributed to the shorter donor‐acceptor distance in the Cu CYS/PVK PNP system. The larger GSH ligand caused steric hindrance, reducing dipole‐dipole interactions and diminishing the FRET efficiency in the Cu GSH/PVK PNP system. These findings demonstrate the role of ligands in modulating FRET performance and designing high‐efficiency MNCs‐based light‐harvesting systems.
Reports of Echolalia and Related Behaviors in Autism From Parents, Teachers, and Clinicians: Evidence From the Simon Simplex Collection
Authors: McAllister Margaret L. , McFayden Tyler , Harrop Clare 
Published: January 2025

ABSTRACTEcholalia, the immediate or delayed repetition of speech, is a core diagnostic criterion for autism spectrum disorder. It has been studied for over 50 years and is well‐described; however, no consensus on prevalence estimates exists for echolalia's occurrence in autistic youth. The current study sought to (1) describe endorsement of echolalia‐related items using parent‐, teacher‐, and clinician‐reports in a well‐validated sample of autistic youth and (2) characterize relations between echolalia and other key factors, including age, language ability, and repetitive behaviors. Participants (n = 2555, 4–17 years, 13% female, 78% White) from the Simon Simplex Collection provided data from multi‐informant ratings of echolalia and related behaviors. Nine parent‐, clinician‐, and teacher‐report items were extracted from five measures to broadly capture echolalia through a composite score. Results indicated that as many as 90% of autistic individuals express echolalia at some point in their development. Hierarchical linear regression was conducted to evaluate relations between echolalia, verbal ability, and repetitive behaviors, controlling for age, sex, and autism severity. Results indicated the main effects of verbal ability and repetitive behaviors. A significant interaction qualified this main effect wherein age was negatively associated with echolalia for children with higher verbal ability, but not those with lower verbal ability, suggesting that adolescents with less generative speech may leverage echolalia as a communicative strategy. Echolalia was positively associated with repetitive behaviors across development. These associations support a dualistic interpretation of echolalia as functional communication and as a form of repetitive behavior. Future research is needed to understand the developmental trajectories of echolalia and develop affirming support for this autistic behavior.
A Reductive Environment‐Assisted Dealloying Approach for Hierarchical Porous Metals in Efficient Magnesium Metal Batteries
Authors: Lee Jun‐Won , Cho YongJun , Jo Hyeonmin , Ryu Hee Seung , Cho Eun Seon , Lim Hee‐Dae 
Published: January 2025

AbstractThis study introduces monolithic three‐dimensional nanoporous magnesium (3D‐NPMg) fabricated through a scalable solution‐based dealloying process as electrodes. By employing a naphthalene‐based reductive environment, this approach forms a hierarchically porous 3D structure with clean metallic surfaces, thereby forming a free‐standing 3D bicontinuous nanostructure. The resulting 3D‐NPMg addresses critical challenges in magnesium metal battery (MMB) anodes, including high polarization, dendritic growth, and limited cycling stability. Electrochemical performance tests show that 3D‐NPMg exhibits lower overpotentials, improved charge‐transfer kinetics, and a significantly extended cycling life. The interconnected porous structure facilitates efficient ionic transport and uniform Mg deposition, thus suppressing volume expansion and reducing top‐plating during cycling. With its rapid oxidation‐minimizing synthesis, this solution‐based dealloying process offers broad applications across various metals, which can advance the development of stable, high‐performance anodes for next‐generation MMBs.
The significance of isolated de novo red patches in the bladder in patients referred with suspected urinary tract cancer: Results from the IDENTIFY study
Authors: Khadhouri Sinan , Gallagher Kevin , MacKenzie Kenneth R. , Shah Taimur T. , Gao Chuanyu , Zimmermann Eleanor , Mannas Miles , Lee Taeweon , Marra Giancarlo , Gomez Rivas Juan , Marcq Gautier , Assmus Mark A. , Ucar Taha , Claps Francesco , Boltri Matteo , Pizzuto Giuseppe , Burnhope Tara , Nkwam Nkwam , Tanasescu George , Boxall Nicholas E. , Downey Alison P. , Sukhu Troy A. , Antón‐Juanilla Marta , Rai Sonpreet , Moore Madeline , Bandeira de Mello Kathryn , Parsons Sian , McGrath John S. , Kasivisvanathan Veeru ,   IDENTIFY Study Group: Pubmed indexed collaborator authors
Published: January 2025

AbstractObjectivesTo assess the contemporary malignancy rate in isolated de novo red patches in the bladder and associated risk factors for better selection of red patch biopsy.PatientsPatients from the IDENTIFY dataset; Patients referred to secondary care with suspected urinary tract cancer and found to have isolated de novo red patches on cystoscopy.MethodsWe reported the unadjusted cancer prevalence in isolated de novo red patches that were biopsied; multivariable logistic regression was used to explore cancer‐associated risk factors including age, sex, smoking, type of haematuria, LUTS, UTIs and a suspicious‐looking red patch (as reported by the cystoscopist). Sub‐analysis of these by clinical role and experience was performed.ResultsA total of 1110 patients with isolated de novo red patches were included. 41.5% (n = 461) were biopsied, with a malignancy rate of 12.8% (59/461), which was significantly higher in suspicious versus non‐suspicious red patches (19.1% vs. 2.81%, p < 0.01). There was a significant association between bladder cancer and age (OR 1.04, 95% CI 1.01–1.07, p = 0.01), smoking history (OR 2.62, 95% CI 1.09–6.27, p = 0.03) and suspicious‐looking patch (OR 6.50, 95% CI 2.47–17.1, p < 0.01). The majority of malignancies were in over 60‐year‐olds. Malignancy rates in suspicious versus non‐suspicious red patches did not differ significantly between clinical roles or experiences.Limitations included subjectivity in classifying a suspicious patch and selection bias as not all patches were biopsied.ConclusionsMany patients still undergo unnecessary biopsies under general anaesthetic for isolated de novo red patches. Clinicians should consider the patient's age, smoking status and how suspicious‐looking the patch is, before deciding on surveillance versus biopsy to improve cancer diagnostic yield.
Developmental Toxicity of Disinfection Byproducts in F344 Rats: Effects on Pregnancy Maintenance and Eye Development
Authors: Narotsky Michael G. , Fuentes Leslie S. , Ola Oluwabusola , Willoughby TaCriasha L. , Lucas Katherine 
Published: January 2025

ABSTRACTBackgroundEpidemiological studies report associations of drinking water disinfection byproducts (DBPs) with adverse health outcomes, including birth defects. Here, we used a rat model susceptible to pregnancy loss (full‐litter resorption; FLR) and eye malformations (anophthalmia, microphthalmia) to test 11 DBPs, including trihalomethanes, haloacetic acids (HAAs), and nitrogen‐containing DBPs (N‐DBPs).MethodsTimed‐pregnant F344 rats received gavage doses of chloroform, chlorodibromomethane, iodoform, chloroacetic acid, bromoacetic acid, dibromoacetic acid (DBA), diiodoacetic acid (DIA), trichloroacetic acid (TCA), dibromonitromethane, and iodoacetonitrile on gestation days (GD) 6–10. Bromonitromethane and TCA were administered via drinking water on GD 6–11. Litters were examined on postnatal days 1 and 6.ResultsAll trihalomethanes tested caused FLR. The di‐ and tri‐halogenated HAAs, but not the mono‐HAAs, caused eye malformations. N‐DBPs caused neither effect at the dosages tested. TCA by gavage caused both FLR and eye defects, whereas drinking water exposure only caused eye defects. Potency rankings for causing FLR were chloroform ≥ iodoform > chlorodibromomethane and the rankings for causing eye defects were DIA > TCA = DBA.ConclusionWe confirmed that trihalomethanes caused pregnancy loss and that di‐ and tri‐HAAs were teratogenic. The N‐DBPs induced neither effect. Potency rankings were inconsistent with rankings seen in vitro.
An Electrochemiluminescence Biosensor for Detection of Methyl Parathion With a Novel Probe Ru‐MIL‐100 via the Acetylcholinesterase Inhibition Coupled With the Reaction Between HAc and Triethylamine
Authors: Zhang Xuhui , Chen Yafei , Ling Jun , Li Jianping 
Published: January 2025

ABSTRACTIt is of great significance to develop sensors for trace pesticide residues detection in food. Herein, an electrochemiluminescence (ECL) sensor with high sensitivity for the detection of methyl parathion (MP) was constructed by combining of the acetylcholinesterase (AChE) enzyme‐inhibited reaction with tris‐2,2′‐bipyridyl ruthenium Ru(bpy)32+‐triethylamine (TEA) system for the first time. A new ECL probe of MIL‐100 loaded with Ru(bpy)32+(Ru‐MIL‐100) was synthesized, and then Ru‐MIL‐100 and AChE were immobilized on the electrode with Nafion. Triethylamine was used as a coreactant to form a Ru‐MIL‐100–TEA luminescence system. The hydrolysis of iodinated acetylthiocholine by AChE to generate acetic acid that consumes TEA, leading to the quenching of ECL of the Ru‐MIL‐100–TEA system. But MP can inhibit the activity of AChE, which leads to the decrease of the generated acetic acid and the enhancement of ECL. With the increase of the MP concentration, the ECL intensity increases. Due to the high catalytic activity of the AChE and the excellent ECL luminescence performance of the Ru‐MIL‐100 probe, the sensor is highly sensitive. The detection concentration range of MP was 1.0 × 10−12–1.0 × 10−9 mol/L, and the detection limit was 2.07 × 10−13 mol/L. The biosensor was applied to the determination of MP in vegetable samples.
The Effect of Accessibility of Insoluble Substrate on the Overall Kinetics of Enzymatic Degradation
Authors: Petrášek Zdeněk , Nidetzky Bernd 
Published: January 2025

ABSTRACTThe enzymatic reaction kinetics on cellulose and other solid substrates is limited by the access of the enzyme to the reactive substrate sites. We introduce a general model in which the reaction rate is determined by the active surface area, and the resulting kinetics consequently reflects the evolving relationship between the exposed substrate surface and the remaining substrate volume. Two factors influencing the overall surface‐to‐volume ratio are considered: the shape of the substrate particles, characterized by a single numerical parameter related to its dimensionality, and the distribution of the particle sizes. The model is formulated in a form of simple analytical equations, enabling fast and efficient application to experimental data, and facilitating its incorporation into more detailed and complex models. The application of the introduced formalism exploring its potential to account for the observed reaction rate is demonstrated on two examples: the derivation of particle size distribution from experimentally determined reaction kinetics, and the prediction of reaction slowdown from experimental particle size distribution.
Bridging Competitive Advantage and Sustainable Development: The Moderating Role of Value Creation for Stakeholders in Ethiopian SMEs
Authors: Tolossa Abebe Techan , Singh Manjit , Gautam Raj Kumar 
Published: January 2025

ABSTRACTThe pursuit of sustainable development has become a crucial priority for businesses globally. Small and Medium Enterprises (SMEs), which form the backbone of many economies, are essential in driving this agenda. However, the challenge of balancing economic growth with environmental stewardship and social responsibility is particularly pronounced for SMEs in developing countries like Ethiopia. This study explores the complex interplay between competitive advantage, sustainable development, and the moderating role of value creation for stakeholders in Ethiopian SMEs. By investigating how SMEs can generate value for various stakeholders while simultaneously strengthening their competitive edge and promoting sustainable development, the research seeks to provide strategic insights for long‐term success. Utilizing a mixed‐methods approach, data were gathered from 387 SME employees in the Oromia Regional State via a self‐administered Likert‐scale questionnaire. The analysis, conducted through structural equation modeling, indicates that competitive advantage positively affects sustainable development. Additionally, the study highlights that value creation for stakeholders significantly moderates this relationship, amplifying the positive influence of competitive advantage on sustainable development. These findings emphasize the importance of prioritizing stakeholder engagement in fostering sustainable business practices. The research contributes to understanding SME sustainability by offering actionable recommendations for policymakers, industry leaders, and academics committed to building competitive and sustainable SMEs in Ethiopia.
Mesenchymal stem cell extracellular vesicle vascularization bioactivity and production yield are responsive to cell culture substrate stiffness
Authors: Powsner Emily H. , Kronstadt Stephanie M. , Nikolov Kristin , Aranda Amaya , Jay Steven M. 
Published: January 2025

AbstractMesenchymal stem cell‐derived extracellular vesicles (MSC EVs) are an attractive therapeutic option for regenerative medicine applications due to their inherently pro‐angiogenic and anti‐inflammatory properties. However, reproducible and cost‐effective production of highly potent therapeutic MSC EVs is challenging, limiting their translational potential. Here, we investigated whether the well‐characterized responsiveness of MSCs to their mechanical environment—specifically, substrate stiffness—could be exploited to generate EVs with increased therapeutic bioactivity without the need for biochemical priming or genetic manipulation. Using polydimethylsiloxane and bone marrow‐derived MSCs (BM‐MSCs), we show that decreasing the stiffness of MSC substrates to as low as 3 kPa significantly improves the pro‐angiogenic bioactivity of EVs as measured by tube formation and gap closure assays. We also demonstrate that lower substrate stiffness improves EV production and overall yield, important for clinical translation. Furthermore, we establish the mechanoresponsiveness of induced pluripotent stem cell‐derived MSC (iMSC) EVs and their comparability to BM‐MSC EVs, again using tube formation and gap closure assays. With this data, we confirm iMSCs' feasibility as an alternative, renewable cell source for EV production with reduced donor variability. Overall, these results suggest that utilizing substrate stiffness is a promising, simple, and a potentially scalable approach that does not require exogenous cargo or extraneous reagents to generate highly potent pro‐angiogenic MSC EVs.
Frequency of Missing TNM Stage Data for Adults With Intellectual or Developmental Disabilities in a Provincial Cancer Registry—A Brief Report
Authors: Biggs Kelly , Ouellette‐Kuntz Helene , Griffiths Rebecca , Hansford Rebecca , Hallet Julie , Kelly Christine , Decker Kathleen , Dawe David E. , Shooshtari Shahin , Brownell Marni , Turner Donna , Cobigo Virginie , Mahar Alyson 
Published: January 2025

ABSTRACTBackgroundAdults with intellectual or developmental disability (IDD) are at higher risk for incomplete cancer staging.AimTo compare unknown stage data between those with and without IDD.Materials and MethodsWe used the Ontario Cancer Registry linked to administrative health data between 2007 and 2019.ResultsAdults with IDD diagnosed with breast, colorectal, and lung cancer were 1.94 (95% CI 1.52–2.47), 1.90 (95% CI 1.63–2.21), and 2.17 (95% CI 1.86–2.54) times more likely to have unknown cancer stage at diagnosis, relative to those without IDD.DiscussionThe absence of stage data has person‐level and population‐level implications. At the individual level, if stage data are not simply missing from the registry but reflect incomplete or absent diagnostic or staging procedures, this may represent barriers for adults with IDD in receiving curative treatment. At the population level, research using inaccurate or incomplete stage data may lead to unrepresentative health and social system policy decisions.ConclusionA better understanding of the cancer diagnostic interval for adults with IDD is needed to develop interventions.
The Effect of Parental Education on Children's Digital Device Usage and Sleep Patterns: A Randomised Controlled Trial
Authors: Bulduk Mehmet , Güdücü Tüfekci Fatma 
Published: January 2025

ABSTRACTAimThe aim of this study was to examine the effects of education given to parents with children between the ages of 6 months and 2 years on children's digital device use time and sleep status.MethodsThe study was conducted as a randomised controlled trial and was carried out in a Family Health Centre in Turkey between July 2020 and April 2021. The population consisted of parents (N = 166) who met the inclusion criteria. No sampling method was used and the entire population was studied. Parents were given education on the use of digital devices for their children. Data were obtained with a personal information form, digital device use form and child sleep form. The data were analysed with SPSS V23. Ethical principles were followed.ResultsWhile the majority of the children in the experimental group watched TV for 60 min or more in the pretest, this rate decreased significantly in the posttest (p < 0.001), and in the comparison between the groups, it was found that the TV watching duration of the children in the posttest showed a significant difference in favour of the experimental group (p < 0.001). A significant difference was found in favour of the experimental group in terms of the effects of digital devices on children's sleep (p < 0.001). A significant difference was found in favour of the experimental group in terms of children's sleep time (p < 0.001), time to fall asleep (p < 0.001), night‐time (p < 0.05) and daytime sleep characteristics (p < 0.05) and total daily sleep duration (p < 0.001).ConclusionThe education provided to the parents about the negative effects of digital device use on children's sleep status met the need for information; thus, it was effective in the formation of positive knowledge and views. Routine implementation of educational programmes for parents about children's use of digital devices may provide good results for healthy generations.
Therapeutic Efficacy Studies on the Monoterpenoid Hinokitiol in the Treatment of Different Types of Cancer
Authors: Bhuia Md. Shimul , Chowdhury Raihan , Afroz Meher , Akbor Md. Showkot , Al Hasan Md. Sakib , Ferdous Jannatul , Hasan Rubel , de Alencar Marcus Vinícius Oliveira Barros , Mubarak Mohammad S. , Islam Muhammad Torequl 
Published: January 2025

ABSTRACTHinokitiol (HK), a monoterpenoid that naturally occurs in plants belonging to the Cupressaceae family, possesses important biological activities, including an anticancer effect. This review summarizes its anticancer potential and draws possible molecular interventions. In addition, it evaluates the biopharmaceutical, toxicological properties, and clinical application of HK to establish its viability for future advancement as a dependable anticancer medication. The assessment is based on the most recent information available from various databases. Findings demonstrate that HK possesses substantial therapeutic advantages against diverse types of cancer (colon, cervical, breast, bone, endometrial, liver, prostate, oral, and skin) through various molecular mechanisms. HK induces oxidative stress, cytotoxicity, apoptosis, cell‐cycle arrest at the G and S phases, and autophagy through modulation of phosphatidylinositol 3‐kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR), p38/ERK/MAPK, nuclear factor kappa B, and c‐Jun N‐terminal kinase signaling pathways. Furthermore, this compound exhibits good oral bioavailability with excellent plasma clearance. Clinical uses of HK demonstrate therapeutic advantages without any significant negative effects. A thorough study of the pertinent data suggests that HK may serve as a viable candidate for developing novel cancer therapies. Consequently, more extensive studies are necessary to evaluate its cancer treatment efficacy, safety, and possible long‐term hazards.