bluuebunny/crossref_metadata_2025_split huggingface dataset:
Coach and player rating of perceived challenge (RPC) as a skill monitoring tool in Rugby union
Authors: Bam Jenna , Watson Neil , Parker Naasier , Lambert Mike , Jones Ben , Weston Matthew , Hendricks Sharief 
Published: May 2023

Objective To determine the relationship between player and coach rating of perceived challenge (RPC) for different training sessions over a competitive rugby union season. A secondary aim was to explore the relationship between player RPC and player session rating of perceived exertion (RPE). Methods We used an observational longitudinal study design to monitor 51 male highly-trained under 21 rugby union players and four coaches over an 11-week competitive rugby season (a total of 1798 training session observations). Player RPC (0 to 10 arbitrary units (AU)) and RPE ratings (0 to 10 AU) were collected after team sessions (a technical and tactical field-based session with all players training together), split sessions (a technical and tactical field-based session where players trained separately according to their positional grouping (forward and backs)) and gym sessions (non-field-based session with all players training together). Coach RPC ratings were only collected after team sessions and split sessions. Results A weak positive relationship (rho = 0.26; 95% CI: 0.09–0.42; p < .001) was found for split sessions (player RPC: 4.40; 95% CI: 3.87–4.87 AU; coach RPC: 4.25; 95% CI: 3.92–4.60 AU), while a moderate positive relationship (rho = 0.37; 95% CI: 0.31–0.43; p < .001) was found between player RPC (4.29; 95% CI: 4.00–4.55) and coach RPC (4.96; 95% CI: 4.89–5.05) for team sessions. Forwards had a higher RPC (5.33; 95% CI: 4.50–5.65) compared to backs (3.45; 95% CI: 2.88–4.00) for split ( p < .001) and team sessions (forward's RPC: 4.66; 95% CI: 4.37–4.94; back's RPC: 3.84; 95% CI: 3.38–4.26; p < .001). Conclusions In conclusion, using a rating to quantify the perceived challenge of training, we found coaches may be overestimating how challenging their training sessions are. Forwards-rated field sessions more challenging than backs, which likely represents their additional technical and tactical demands from training scrums, line-outs and mauls. While the RPC has strong theoretical justification as a rating tool to potentially fulfil the gap of quantifying the perceived challenge of training, thoughtful validity studies are yet to be conducted on the scale, which are the required next steps if the RPC is going form part of a coach's and practitioner's toolbox to optimise skill training.
Comparing Glucose Outcomes Following Face-to-Face and Remote Initiation of Flash Glucose Monitoring in People Living With Diabetes
Authors: Kingsnorth Andrew P. , Wilson Caroline , Choudhary Pratik , Griffin Tomás P. 
Published: May 2023

Background: When launched, FreeStyle Libre (FSL; a flash glucose monitor) onboarding was mainly conducted face-to-face. The COVID-19 pandemic accelerated a change to online starts with patients directed to online videos such as Diabetes Technology Network UK for education. We conducted an audit to evaluate glycemic outcomes in people who were onboarded face-to-face versus those who were onboarded remotely and to determine the impact of ethnicity and deprivation on those outcomes. Methods: People living with diabetes who started using FSL between January 2019 and April 2022, had their mode of onboarding recorded and had at least 90 days of data in LibreView with >70% data completion were included in the audit. Glucose metrics (percent time in ranges) and engagement statistics (previous 90-day averages) were obtained from LibreView. Differences between glucose variables and onboarding methods were compared using linear models, adjusting for ethnicity, deprivation, sex, age, percent active (where appropriate), and duration of FSL use. Results: In total, 935 participants (face-to-face 44% [n = 413]; online 56% [n = 522]) were included. There were no significant differences in glycemic or engagement indices between onboarding methods and ethnicities, but the most deprived quintile had significantly lower percent active time (b = −9.20, P = .002) than the least deprived quintile. Conclusions: Online videos as an onboarding method can be used without significant differences in glucose and engagement metrics. The most deprived group within the audit population had lower engagement metrics, but this did not translate into differences in glucose metrics.
Successful autologous transfusion from the subcutaneous space in a domestic shorthair cat with suspected anticoagulant rodenticide toxicity
Authors: Nash Katherine J , Yeo Amanda , Munce Katherine 
Published: May 2023

Case summary A 6-month-old female entire domestic shorthair cat was presented with a 4-day history of progressive swelling over the dorsal cranium. Subsequent diagnostics revealed a large haematoma, a secondary haemostatic defect and a moderate anaemia. The owner disclosed access to multiple brodifacoum bait stations. The anaemia and haematoma progressed despite treatment with fresh frozen plasma and phytonadione and the cat developed signs of haemorrhagic shock. Allogenic transfusion was declined due to cost and 18 ml of blood was aspirated from the haematoma and transfused. The cat stabilised quickly and was discharged the next day with oral phytonadione. Relevance and novel information Autologous transfusion from the subcutaneous space has not been previously reported. It was well tolerated and life-saving in this case.
The role of accelerator programmes in supporting the adoption of digital health technologies: A qualitative study of the perspectives of small- and medium-sized enterprises
Authors: Njoku Chidi , Green Hofer Stuart , Sathyamoorthy Ganesh , Patel Neelam , Potts Henry WW 
Published: May 2023

Objective Evidence-based digital health technologies are increasingly important in delivering care to an ageing population with constrained resources. In the United Kingdom, accelerator programmes (APs) have been developed to support the adoption of digital health technologies within the National Health Service. This study aims to explore the perspectives of stakeholders using APs. Methods Stakeholders representing nine small -and medium-sized enterprises (SMEs) that were engaged with three different APs ( n = 9). Semi-structured interviews were conducted with key informants between April and September 2018. Framework analysis of the data was performed to explore their perspectives on APs. Results Four key themes were generated. Informants reported the need to generate evidence before and during the programme, appreciating different types of evidence and their importance. Informants identified several key factors that were a catalyst for success, including involvement in the programme and access to individuals and organisations that were crucial for support. However, several barriers were identified at the programme and system levels. Finally, informants identified key supporting processes that enhanced the adoption of their innovations. Conclusion SMEs that develop digital health technologies report that, while APs are useful in supporting the adoption of these technologies, some issues remain. These relate to the emphasis on traditional research evidence that remains a challenge for SMEs to generate. Also, several system-level barriers to innovation in healthcare persist. As APs and SMEs continue to create an entrepreneurial ecosystem, there is increased potential for the development of supporting processes and infrastructure to accelerate the efficient and timely adoption of new digital health technologies.
A study to explore the usefulness of a mobile health application to support people with mild cognitive and/or communication impairment due to dementia and their carers
Authors: Cheraghi-Sohi Sudeh , Davies Karen , Gordon Lorenzo , Jones Huw , Sanders Caroline , Ong Bie Nio 
Published: May 2023

Background Mobile apps for health (mHealth) have the potential to support people living with dementia. However, dementia is a complex and progressive condition that imposes specific constraints on the introduction/use of mhealth. Few studies have explored mHealth adoption and use within the complexity of everyday domestic settings. This study used an existing App co-designed with people living with mild cognitive and communication impairment (PWMCCI) due to learning disabilities and examined the usefulness for PWMICCI due to dementia and their carers. Methods A qualitative study of people with dementia and their carers. Data were collected in a phased approach to identify the potential need for, as well as the usability and utility of the app. Analysis employed the Domestication of Technology Model (DTM) to explore, in a novel way mHealth, in this user group(s). Results Most participants did not adopt the mHealth during the study period but some ( n  =  2) did routinely as it fulfilled a unique, unmet need. The use of DTM highlighted the complexities of dementia, pressure on carers and duplication of effort created barriers to app adoption and use in the long term. Conclusions The ability of mHealth to support PWMCCI due to dementia and/or their carers may have potential. Users were motivated to try the technology but for any potential to be fully realised, the interplay between complexity of the condition including its progressive nature, demand on carers and nature of the technology needs to be more fully understood. Such issues place unique constraints around the size and window of opportunities for mHealth in this user group.
Smartphone addiction, gender and interpersonal attachment: A cross-sectional analytical survey in Taiwan
Authors: Wu Yi-Ying , Chou Wen-Huei 
Published: May 2023

Overview Smartphone use has dramatically increased worldwide, contributing to a profound change in interpersonal interactions. They have become the primary medium of human interaction, and smartphone addiction, consequently, has become a modern-day reality. Recent research on smartphone addiction has provided diverse explanations regarding the correlation between gender and addiction. Therefore, this study aims to analyse the correlation and variance among smartphone addiction, gender and interpersonal attachment. Methods The participants included Taiwanese citizens and the questionnaires were randomly distributed; 1190 valid questionnaires (534 males, 656 females) were collected. Descriptive statistics were computed to observe the average value and standard deviation between interpersonal attachment and gender. Next, Spearman's ρ was conducted to interpret the correlation among smartphone addiction, gender and interpersonal attachment. Finally, the participants were divided into three groups based on their pre-determined level of smartphone addiction: high, moderate and low addictions. The Analysis of variance (ANOVA) was performed based on interpersonal attachment as the independent variable to determine any statistically significant difference among the three levels. Results There are four patterns of interpersonal attachment: secure, avoidant, dismissing and anxious attachments. The correlation analysis revealed a significant positive correlation between interpersonal attachment and smartphone addiction ( p > 0.000), while revealing no relationship between gender and smartphone addiction or gender and interpersonal attachment. Additionally, the ANOVA indicated the difference was statistically significant in the groups of high and moderate addictions; no statistical significance was identified in the group of low addiction ( p  < 0.204). Conclusion This study revealed that there was no correlation between gender and smartphone addiction, but rather, a positive correlation between smartphone addiction and interpersonal attachment. This positive correlation suggests both high and moderate addiction groups display insecurity in their interpersonal attachment. Therefore, to lower the prevalence of unhealthy smartphone addiction, maintaining healthy interpersonal relationships is suggested.
Perception and Acceptance of COVID-19 Vaccine Among Nurses in Jordan
Authors: Rezq Khulud Ahmad , AI_Zaghmouri Abeer Hesham 
Published: May 2023

Introduction Vaccination against coronavirus disease (COVID-19) is a key factor in protecting vulnerable populations, reducing healthcare burdens, and mitigating the economic and social impacts of the pandemic. Objective This study aims to investigate Jordanian nurses’ perceptions, acceptance, and factors affecting their decisions toward the COVID-19 vaccines. Methods In this study, we conducted a cross-sectional design. Data have been investigated between July 1, 2021 and August 30, 2021. Nurses at three private hospitals in Jordan were surveyed online. The online survey, created using Google Forms, was distributed to nurses via email and social media sites (e.g., WhatsApp and Facebook). Participants were eligible if they were a RN nurse and/or nursing assistance, and had access to the internet via computer and/or smartphone. Results Out of 189 responses, 50.6% agreed to receive the COVID-19 vaccine, while 25.5% disagreed, and 23.9% were undecide to receive the vaccine. A large proportion (84.66%) of the respondents had a negative perception toward the vaccine, while only a small minority (15.34%) had a positive perception of it. The older nurses, those with more experience, and those with a higher level of education were more likely to accept the vaccine, with acceptance rates of 56.1%, 54.8%, and 63.9%, respectively. Conclusion Of the nurses surveyed, 84.66% had a negative perception of the COVID-19 vaccine, and only 50.6% reported that they would be willing to get vaccinated. It is crucial to address the concerns and reduce apprehension among nurses about the vaccine. Efforts to increase awareness about the importance of vaccination in controlling the disease through workshops and online meetings are needed.
The effect of Lu AG09222 on PACAP38- and VIP-induced vasodilation, heart rate increase, and headache in healthy subjects: an interventional, randomized, double-blind, parallel-group, placebo-controlled study
Authors: Rasmussen Nadja Bredo , Deligianni Christina , Christensen Casper Emil , Karlsson William Kristian , Al-Khazali Haidar Muhsen , Van de Casteele Tom , Granhall Charlotte , Amin Faisal Mohammad , Ashina Messoud 
Published: May 2023

Abstract
Background
Pituitary adenylate cyclase-activating polypeptide (PACAP), structurally related to vasoactive intestinal peptide (VIP), is one of the important mediators in the pathogenesis of migraine and is known to dilate cranial arteries and induce headache and migraine. Our objective was to determine whether Lu AG09222—an investigational humanized monoclonal antibody directed against PACAP ligand—would inhibit the PACAP-signaling cascade by abolishing its vasodilatory and headache-inducing abilities.

Methods
In a randomized, double-blind, parallel-group, single-dose, placebo-controlled study of Lu AG09222, healthy volunteers aged 18–45 years without history of headache disorders were randomly allocated to three treatment sequences (1:2:2) on two experimental infusion visits with 9 ± 3 days’ interval: placebo + saline + saline (n = 5), placebo + PACAP38 + VIP (n = 10), and Lu AG09222 + PACAP38 + VIP (n = 10). The primary outcome measure was area under the curve (AUC) of the change in superficial temporal artery (STA) diameter from 0 to 120 min after start of infusion of PACAP38. The study was conducted at the Danish Headache Center in Copenhagen, Denmark.

Results
In participants who received Lu AG09222 + PACAP38 infusion, there was a significantly lower STA diameter (mean (SE) [95% CI] AUC ‒35.4 (4.32) [‒44.6, ‒26.3] mm × min; P < 0.0001) compared to participants who received placebo + PACAP38 infusion. Secondary and explorative analysis revealed that PACAP38 infusion induced an increase in facial blood flow, heart rate and mild headache, and indicated that these PACAP38-induced responses were inhibited by Lu AG09222.

Conclusions
This proof-of-mechanism study demonstrated that Lu AG09222 inhibited PACAP38-induced cephalic vasodilation and increases in heart rate, and reduced concomitant headache. Lu AG09222 may be a potential therapy against migraine and other PACAP-mediated diseases.

Trial registration
ClinicalTrials.gov: NCT04976309. Registration date: July 19, 2021.

Graphical Abstract
Structural and optical analyses for InGaN-based red micro-LED
Authors: Hsiao Fu-He , Miao Wen-Chien , Hong Yu-Heng , Chiang Hsin , Ho I-Hung , Liang Kai-Bo , Iida Daisuke , Lin Chun-Liang , Ahn Hyeyoung , Ohkawa Kazuhiro , Chang Chiao-Yun , Kuo Hao-Chung 
Published: May 2023

AbstractThis study presents a comprehensive analysis of the structural and optical properties of an InGaN-based red micro-LED with a high density of V-shaped pits, offering insights for enhancing emission efficiency. The presence of V-shaped pits is considered advantageous in reducing non-radiative recombination. Furthermore, to systematically investigate the properties of localized states, we conducted temperature-dependent photoluminescence (PL). The results of PL measurements indicate that deep localization in the red double quantum wells can limit carrier escape and improve radiation efficiency. Through a detailed analysis of these results, we extensively investigated the direct impact of epitaxial growth on the efficiency of InGaN red micro-LEDs, thereby laying the foundation for improving efficiency in InGaN-based red micro-LEDs.
Significant extravasation does not preclude conservative management of spontaneous perforation of the augmented bladder
Authors: Abdelhalim Ahmed , Hafez Ashraf T. 
Published: May 2023

Abstract
Background
Perforation of the augmented bladder is a serious and well-known complication of bladder augmentation. The traditional treatment has been emergent surgical exploration and repair of the bladder perforation due to the risk of peritonitis, sepsis and mortality. Some studies have reported successful conservative management by maximizing bladder drainage in patients with stable hemodynamics and limited peritoneal extravasation. Herein, we report the successful conservative management of spontaneous perforation of augmented bladder in a 5-year-old boy with exstrophy-epispadias complex following epispadias repair with significant extravasation.

Case presentation
A 5-year-old boy had augmentation ileocystoplasty to facilitate repair of failed bladder exstrophy closure. Modified penile disassembly was used for epispadias repair with a transurethral catheter draining the bladder. The patient presented on postoperative day 2 with a non-draining catheter, fever, repeated vomiting and abdominal distension. Leukocytosis and elevated creatinine were evident on laboratory work-up. CT cystogram confirmed the diagnosis of spontaneous perforation of the augmented bladder with significant intraperitoneal extravasation. Conservative management was successful by inserting a suprapubic catheter and an intraperitoneal drain. The patient subsequently underwent creation of Mitrofanoff appendicovesicostomy and bladder neck closure to achieve dryness without recurrence of perforation on follow-up.

Conclusions
Perforation of the augmented bladder can be managed conservatively even in the presence of significant peritoneal extravasation by maximizing bladder drainage and insertion of an image-guided intraperitoneal drain.
Factors associated with long-term mechanical ventilation in patients undergoing cardiovascular surgery
Authors: Rahimi Shahram , Abdi Alireza , Salari Nader , Shohaimi Shamarina , Naghibeiranvand Mehran 
Published: May 2023

AbstractBackgroundOne of the main therapy for coronary artery disease is surgery. Prolonged mechanical ventilation in patients with cardiac surgery is associated with high mortality. This study aimed to determine the factors related to long-term mechanical ventilation (LTMV) in patients undergoing cardiovascular surgery.MethodsThe present study was a descriptive-analytical study in which the records of 1361 patients who underwent cardiovascular surgery and were on a mechanical ventilator during 2019–2020 at the Imam Ali Heart Center in Kermanshah city were examined. The data collection tool was a three-part researcher-made questionnaire including demographic characteristics, health records, and clinical variables. Data analysis was done using descriptive and inferential statistical tests and SPSS Version 25 software.ResultsIn this study, of the 1361 patients, 953 (70%) were male. The results indicated that 78.6% of patients had short-term mechanical ventilation, and 21.4% had long-term mechanical ventilation. There was a statistically significant relationship between the history of smoking, drug use, and baking bread with the type of mechanical ventilation (P < 0.05). Also, based on the regression test, some parameters, such as the history of respiratory conditions, could predict the prolongation of mechanical ventilation. Creatinine levels before surgery, chest secretions after surgery, central venous pressure after surgery, and the status of cardiac enzymes before surgery also affect this issue.ConclusionThis study investigated some factors related to prolonged mechanical ventilation in patients undergoing heart surgery. For optimizing the care and therapeutic measures, It is suggested, healthcare workers have a detailed assessment on patients with factors such as the history of baking bread, history of obstructive pulmonary disease, history of kidney disease, use of an intra-aortic pump, number of respirations and systolic blood pressure 24 h after surgery, creatinine level 24 h after surgery, chest secretions after surgery, and the amount of pre-operative ejection fraction and cardiac enzymes (CK-MB).
Stratified split sampling of electronic health records
Authors: Huo Tianyao , Glueck Deborah H. , Shenkman Elizabeth A. , Muller Keith E. 
Published: May 2023

AbstractAlthough superficially similar to data from clinical research, data extracted from electronic health records may require fundamentally different approaches for model building and analysis. Because electronic health record data is designed for clinical, rather than scientific use, researchers must first provide clear definitions of outcome and predictor variables. Yet an iterative process of defining outcomes and predictors, assessing association, and then repeating the process may increase Type I error rates, and thus decrease the chance of replicability, defined by the National Academy of Sciences as the chance of “obtaining consistent results across studies aimed at answering the same scientific question, each of which has obtained its own data.”[1] In addition, failure to account for subgroups may mask heterogeneous associations between predictor and outcome by subgroups, and decrease the generalizability of the findings. To increase chances of replicability and generalizability, we recommend using a stratified split sample approach for studies using electronic health records. A split sample approach divides the data randomly into an exploratory set for iterative variable definition, iterative analyses of association, and consideration of subgroups. The confirmatory set is used only to replicate results found in the first set. The addition of the word ‘stratified’ indicates that rare subgroups are oversampled randomly by including them in the exploratory sample at higher rates than appear in the population. The stratified sampling provides a sufficient sample size for assessing heterogeneity of association by testing for effect modification by group membership. An electronic health record study of the associations between socio-demographic factors and uptake of hepatic cancer screening, and potential heterogeneity of association in subgroups defined by gender, self-identified race and ethnicity, census-tract level poverty and insurance type illustrates the recommended approach.