bluuebunny/crossref_metadata_2025_split huggingface dataset:
The value of the wireless stethoscope in patients with COVID-19 infection in a makeshift hospital
Authors: Zhuge Ying , Rong Liu , Ye Lei , Liu Jiaqi , Su Lingyun , Zhang Zhiping , Wang Junshan , Zhang Zhi 
Published: July 2023

Abstract
Objective
When COVID-19 sweeps the world, traditional stethoscopes are seen as infectious agents and then the use of stethoscopes is limited especially when health providers were in their personal protective equipment. These reasons led to the ignoring of the values of stethoscopes during pandemics. This study aims to explore the value of wireless stethoscopes in patients of a makeshift hospital.

Material and methods
200 consecutive hospitalized patients with confirmed SARS-CoV-2 at Lingang Makeshift Hospital in Shanghai, China, were enrolled from April 10 to May 10, 2022 (Trial Registration Number: ChiCTR2000038272,2020/9/15). They were randomly divided into two groups. In group A (n = 100), patients were examined without a stethoscope. In group B (n = 100), lung breath sounds and heart sounds were examined with a wireless stethoscope, and positive signs were recorded. The duration of cough and tachycardia symptoms, as well as emergency cases, were compared between the two groups. In addition, the pressure, anxiety, and depression of patients in the two groups were investigated using the DAS-21 questionnaire scale, to observe the psychological impact of the stethoscope-based doctor–patient communication on patients in the makeshift hospital.

Results
There was no significant difference in baseline characteristics between the two groups. In group B, some significant positive signs were detected by wireless stethoscopes, including pulmonary rales and tachycardia, etc. Moreover, the therapeutic measures based on these positive signs effectively alleviated the symptoms of cough and tachycardia, which showed that the duration of symptoms was significantly shorter than that of group A (cough: 2.8 ± 0.9 vs. 3.6 ± 0.9; palpitation: 1.4 ± 0.7 vs. 2.6 ± 0.7). In particular, the number of emergency cases in group B is less than that in group A (1% vs. 3%), and the severity is lower. Notably, stethoscope-based doctor–patient communication was found to be effective in alleviating psychological measures of group B patients.

Conclusion
Wireless stethoscopes in makeshift hospitals can avoid cross-infections and detect more valuable positive signs, which can help health providers make accurate decisions and relieve patients' symptoms more quickly. Moreover, stethoscope-based doctor–patient communication can diminish the psychological impacts of the epidemic on isolated patients in makeshift hospitals.
Trial registration This study was registered in the Chinese Clinical Trial (ChiCTR2000038272) at http://www.chictr.org.cn. http://www.chinadrugtrials.org.cn/clinicaltrials.searchlistdetail.dhtml.
An evaluation of the Compassion, Inclusion, and Engagement initiative: learning from PWLE and communities across British Columbia
Authors: Maguet Sally , Laliberte Nancy , Moore Laura , Milkovich Tammy , Burmeister Charlene , Scow Marnie , Sproule Wendy , Dove Naomi , Martens Sheila 
Published: July 2023

Abstract
Background
The Compassion, Inclusion and Engagement initiative (CIE) was a social contact intervention that operated in British Columbia between 2015 and 2021. The primary objective of CIE was to increase the participation of people with lived experience of substance use (PWLE) in the planning, design, implementation, and evaluation of harm reduction supports and services.

Case presentation
CIE used the developmental evaluation methodology outcome mapping to define and measure progress towards its goals. Developmental evaluation emphasizes learning in contrast to other forms of evaluation which are often more focused on determining the value or success of a project or programme based on predetermined criteria. Outcome mapping is a relational practice which acknowledges that change is achieved by an initiative’s partners and the role of the initiative is to provide access to resources, ideas and opportunities that can facilitate and support change.

Conclusions
Through the implementation and evaluation of CIE, it became clear that directly supporting PWLE facilitated more meaningful and lasting change than solely working to improve the health and social services that supported them. The impacts of the CIE initiative extend far beyond the outcomes of any of the dialogues it facilitated and are largely the result of an increase in social capital. CIE engagements created the opportunity for change by inviting people most affected by the toxic drug supply together with those committed to supporting them, but their ability to bring about systemic change was limited. Both PWLE and service providers noted the lack of support to attend CIE engagements, lack of support for actions that came from those engagements, and lack of PWLE inclusion in decision-making by health authorities as limiting factors for systemic change. The lack of response at a systemic level often resulted in PWLE carrying the burden of responding to toxic drug poisonings, often without resources, support, or compensation.
Intracoronary versus intravenous glycoprotein IIb/IIIa inhibitors during primary percutaneous coronary intervention in patients with STEMI: a systematic review and meta-analysis
Authors: Hahn JongSung , Jeon Jinyoung , Geum Min Jung , Lee Hyun Woo , Shin Jaekyu , Chung Woo-Young , Yu Yun Mi , Ah Young-Mi 
Published: July 2023

Abstract
Background
Intracoronary (IC) administration of glycoprotein IIb/IIIa inhibitors (GPIs) has been studied as an adjunctive therapy to improve outcomes in patients with ST-segment elevation myocardial infarction (STEMI) undergoing percutaneous coronary intervention. In this systematic review and meta-analysis, we aimed to evaluate the efficacy and safety of IC administration of GPIs compared with those of intravenous (IV) administration in patients with STEMI.

Methods
We searched the MEDLINE, Embase, and Cochrane CENTRAL databases for relevant studies published before September 21, 2022. In total, 22 randomized controlled trials involving 7,699 patients were included.

Results
The proportions of patients achieving thrombolysis in myocardial infarction grade 3 flow, myocardial blush grade 2/3, and complete ST-segment resolution were significantly higher in the IC group than in the IV group. Major adverse cardiac events (MACE) (RR: 0.54, 95% CI: 0.37–0.80) and heart failure (RR: 0.48, 95% CI: 0.25–0.91) within 1 month were significantly lower in the IC group than in the IV group; however, after 6 months, no difference was observed in MACE risk. Additionally, the risks of death and bleeding did not differ between the two routes of administration.

Conclusions
When considering adjunctive GPI administration for patients with STEMI, the IC route may offer greater benefits than the IV route in terms of myocardial reperfusion and reduced occurrence of MACE and heart failure within 1 month. Nonetheless, when making decisions for IC administration of GPIs, the absence of a benefit for bleeding risk and difficulty accessing the administration route should be considered.
Orchestrating smart therapeutics to achieve optimal treatment in small cell lung cancer: recent progress and future directions
Authors: Zhang Chenyue , Zhang Chenxing , Wang Kai , Wang Haiyong 
Published: July 2023

AbstractSmall cell lung cancer (SCLC) is a recalcitrant malignancy with elusive mechanism of pathogenesis and dismal prognosis. Over the past decades, platinum-based chemotherapy has been the backbone treatment for SCLC. However, subsequent chemoresistance after initial effectiveness urges researchers to explore novel therapeutic targets of SCLC. Recent years have witnessed significant improvements in targeted therapy in SCLC. New molecular candidates such as Ataxia telangiectasia and RAD3-related protein (ATR), WEE1, checkpoint kinase 1 (CHK1) and poly-ADP-ribose polymerase (PARP) have shown promising therapeutic utility in SCLC. While immune checkpoint inhibitor (ICI) has emerged as an indispensable treatment modality for SCLC, approaches to boost efficacy and reduce toxicity as well as selection of reliable biomarkers for ICI in SCLC have remained elusive and warrants our further investigation. Given the increasing importance of precision medicine in SCLC, optimal subtyping of SCLC using multi-omics have gradually applied into clinical practice, which may identify more drug targets and better tailor treatment strategies to each individual patient. The present review summarizes recent progress and future directions in SCLC. In addition to the emerging new therapeutics, we also focus on the establishment of predictive model for early detection of SCLC. More importantly, we also propose a multi-dimensional model in the prognosis of SCLC to ultimately attain the goal of accurate treatment of SCLC.
Ethnobotanical study of underutilized wild edible plants and threats to their long-term existence in Midakegn District, West Shewa Zone, Central Ethiopia
Authors: Guzo Sheleme , Lulekal Ermias , Nemomissa Sileshi 
Published: July 2023

Abstract
Background
Ethiopia is endowed with much plant diversity. The insignificant number of studies on wild edible plants with their ethnobotanical perspectives indicated that this plant diversity comprised only hundreds of wild edible plants used to supplement food sources for the local community under different conditions. There still need to be further investigations throughout the country when compared to the total area and cultural diversity of the country. However, they are seriously under pressure due to different natural and human influences. Therefore, the study was conducted to document underutilized wild edible plants along with their associated indigenous knowledge and explore threats to them in Midakegn District.

Methods
A questionnaire survey, semi-structured interviews, a market survey, score ranking, and focused group discussions were employed for data collection. Statistical analysis of ethnobotanical knowledge mean variation between different informant groups was computed by using one-way ANOVA in the IBM SPSS Statics version 24 package.

Results
A total of fifty underutilized wild edible plants belonging to 39 genera and 30 families were collected, recorded, and documented. The families Moraceae (four), Fabaceae, Flacourtaceae, Myrtaceae, Rosaceae, and Tiliaceae (each three) represented the highest number of species. It comprised shrubs (44%), trees (36%), herbs (18%), and epiphytes (2%). Fruits (62.3%) were found to be the most frequently used and mostly taken raw, fresh, or dried. These edible resources were consumed to supplement staple foods (67.3%), whereas 25% were used as emergency foods. The majority of species (96%) had multiple uses in addition to their edibility. A significantly higher (P < 0.05) number of underutilized wild edible plants were cited by males than females, by key informants than generals, elders than youngsters, illiterate than literate, and poorer than other wealth class groups of the community. Priority rankings indicate that agricultural expansion, fuel wood harvest, overgrazing, and selective harvesting are the most threatening factors to underutilized wild edible plants.

Conclusions
Fifty underutilized wild edible plants, along with their associated indigenous knowledge, were recorded. Local people utilize them for supplementing staple food, as emergency food, to get relief, trust, and chew during drought. But they are mainly threatened by different human activities in the study area.
Invasive Aedes mosquitoes in an urban—peri-urban gradient in northern Spain: evidence of the wide distribution of Aedes japonicus
Authors: Cevidanes Aitor , Goiri Fátima , Barandika Jesús F. , Vázquez Patricia , Goikolea Joseba , Zuazo Ander , Etxarri Natalia , Ocio Gurutze , García-Pérez Ana L. 
Published: July 2023

Abstract
Background
The expansion of invasive mosquitoes throughout Europe has increased in recent decades. In northern Spain, Aedes albopictus was detected for the first time in 2014, and Aedes japonicus was detected in the three Basque provinces in 2020. This study aimed to evaluate the distribution of these mosquito species and their association with factors related to urbanization.

Methods
In 2021, a total of 568 ovitraps were deployed in 113 sampling sites from 45 municipalities with > 10,000 inhabitants. Oviposition substrate sticks were replaced each fortnight and examined for Aedes eggs from June to November. Aedes eggs were counted, and the eggs from a selection of positive oviposition sticks, encompassing at least one stick from each positive ovitrap, were hatched following their life cycle until the adult stage. When egg hatching was not successful, PCR targeting the COI gene and sequencing of amplicons were carried out.

Results
Eggs were detected in 66.4% of the sampling sites and in 32.4% of the ovitraps distributed in the three provinces of the Basque Country. Aedes albopictus and Ae. japonicus were widespread in the studied area, confirming their presence in 23 and 26 municipalities, respectively. Co-occurrence of both species was observed in 11 municipalities. The analysis of the presence of Aedes invasive mosquitoes and the degree of urbanization (urban, suburban, peri-urban) revealed that Ae. albopictus showed a 4.39 times higher probability of being found in suburban areas than in peri-urban areas, whereas Ae. japonicus had a higher probability of being found in peri-urban areas. Moreover, the presence of Ae. albopictus was significantly associated with municipalities with a higher population density (mean = 2983 inh/km2), whereas Ae. japonicus was associated with lower population density (mean = 1590 inh/km2).

Conclusions
The wide distribution of Ae. albopictus and Ae. japonicus observed confirmed the spread and establishment of these species in northern Spain. A new colonization area of Ae. japonicus in Europe was confirmed. Due to the potential impact of Aedes invasive mosquitoes on public health and according to our results, surveillance programs and control plans should be designed considering different urbanization gradients, types of environments, and population density.

Graphical Abstract
Citation of updated and co-published Cochrane Methodology Reviews
Authors: Zhu Linlin , Yang Ziyu , Deng Hongyu , Zhang Yonggang , Liao Xiaoyang , Clarke Mike 
Published: July 2023

Abstract
Background
To evaluate the number of citations for Cochrane Methodology Reviews after they have been updated or co-published in another journal, and the effect of co-publishing the review on the co-publishing journal’s impact factor (IF).

Methods
We identified all Cochrane Methodology Reviews published in the Cochrane Database of Systematic Reviews (CDSR) before 2018 and searched for co-published versions in the Web of Science Core Collection database up to 16 August 2022. The included reviews were in two cohorts: those that had been published and updated in CDSR and those that had been published in CDSR and co-published in another journal. The primary outcome measured the citation number to updated and original reviews in the first five years after publication of the updated review, and assessed the citation number of co-published and non-co-published reviews in the first five years after publication of the co-published version.
The secondary outcome was the ratio of an adjusted IF and the actual IF of the co-publishing journal.

Results
Eight updated and six original reviews were identified for the updated cohort of reviews, and four co-published reviews were included in the co-published cohort. The original reviews continued to be cited after the update was published but the median for the total number of citations was non-significantly higher for the updated reviews than for their original version[161 (Interquartile range (IQR) 85, 198) versus 113 (IQR 15, 433)]. The median number of total citations [362 (IQR 179, 840) versus 145 (IQR 75, 445)] and the median number of citations to the review in the first five years after co-publication combined and in each of those years was higher in the co-published group than in the non-co-published group. One of the three journals that co-published Reviews in the first year and two journals in the second year had a lower IF after co-publication.

Conclusions
Earlier versions of Cochrane Methodology Reviews continue to be cited after an update is published, which raises doubts about whether those citing are using the most recent evidence or are aware of the update. Co-publication facilitates broader application and dissemination of Cochrane methodology evidence.
Exploring gender differences in trait preferences among groundnut value chain actors in northern Ghana
Authors: Yila Jummai O. , Martey Edward , Etwire Prince M. , Adogoba Desmond Sunday , Muricho Geoffrey , Desmae Haile 
Published: July 2023

AbstractAssessing gender differences in trait preferences of groundnut value chain actors can influence the effectiveness of crop breeding programs, the adoption of developed technologies, and policy interventions. However, there is limited evidence to support decisions that meet end users’ demands, given that most studies do not disaggregate trait preferences by sex and age. We use a stated preference method to characterize the preferences and willingness to pay (WTP) for various attributes of improved groundnut varieties by male and female youth and older adults in the different segments of the groundnut value chain. The results indicate heterogeneity in preference and WTP for production, market, and nutrition attributes of groundnut across supply chain actors. The results showed that gender is not a unifying factor in respondents’ WTP, revealing dissimilarities among youth and older adults of the same sex group. Our findings suggest that groundnut breeding programs must prioritize production, market, and nutrition attributes based on gender needs to speed up the process of adoption, commercialization, and utilization of groundnut.
Paleomagnetic evidence for episodic construction of the Mamiyadake tephra ring
Authors: Yasuda Yuki 
Published: July 2023

AbstractTephra rings that surround maar craters are typically inferred from field observations to have been emplaced rapidly over a time period of days to years and thus monogenetic, which is, however, rarely assessed quantitatively. This paper describes a polycyclic origin of the Mamiyadake tephra ring (Japan), comparing the paleomagnetic directions obtained from throughout the stratigraphy. The new data show that the paleomagnetic directions change systematically with stratigraphic height through the sections, which is interpreted to record paleosecular variation (PSV) of the geomagnetic field during formation of the tephra ring. The paleomagnetic results, together with using an average rate of PSV in Japan, indicate that the Mamiyadake tephra ring was constructed episodically with five major eruptive episodes, separated by centuries or longer, over a period of at least 1000 years. The findings demonstrate that detailed paleomagnetic characterization can uncover the temporal evolution of tephra rings, providing a useful criterion for identifying time breaks, even where field evidence is lacking, and a minimum estimate of the time interval for their emplacement. The approach used here may be applicable to volcanoes of any type.
Graphical Abstract
Geophysical investigation of the Mado Megamullion oceanic core complex: implications for the end of back-arc spreading
Authors: Okino Kyoko , Tani Kenichiro , Fujii Masakazu , Zhou Fei , Ishizuka Osamu , Ohara Yasuhiko , Hanyu Tomoko , Matamura Yuki 
Published: July 2023

AbstractDetachment faulting is one of the main styles of seafloor spreading at slow to intermediate mid-ocean ridges. However, we have limited insight into its role in back-arc basin formation. We surveyed a remnant back-arc spreading center in the Philippine Sea and determined the detailed features and formation processes of the Mado Megamullion (Mado MM) oceanic core complex (OCC). This was undertaken in the context of back-arc evolution, based on the shipborne bathymetry, magnetics, and gravity with radiometric age dating of the rock samples collected. The Mado MM OCC has a typical OCC morphology with prominent corrugations on the domed surface and positive gravity anomalies, suggesting that there has been an exposure of the lower crust and mantle materials by a detachment fault. The downdip side of the detachment continues to the relict axial rift valley, which has indicated that the Mado MM OCC was formed at the end of the back-arc basin opening. The spreading rate of the basin decreased once when the spreading direction changed after six million years of stable trench perpendicular spreading. The rate then further decreased immediately prior to the end of the spreading when the Mado MM OCC was formed. The existence of other OCC-like structures in the neighboring segment and the previously reported OCCs along the Parece Vela Rift have indicated that the melt-poor, tectonic-dominant spreading is a widespread phenomenon at the terminal phase of back-arc spreading. The decrease in spreading rate in the later stage is consistent with the previous numerical modeling because of the decrease in trench retreat. In the Izu–Bonin–Mariana arc trench system, the rotation of the spreading axis and the resultant axis segmentation have enhanced the lithosphere cooling and constrained mantle upwelling, which caused the tectonic-dominant spreading at the final phase of the basin evolution.
A systematic review on machine learning and deep learning techniques in the effective diagnosis of Alzheimer’s disease
Authors: Arya Akhilesh Deep , Verma Sourabh Singh , Chakarabarti Prasun , Chakrabarti Tulika , Elngar Ahmed A. , Kamali Ali-Mohammad , Nami Mohammad 
Published: July 2023

AbstractAlzheimer’s disease (AD) is a brain-related disease in which the condition of the patient gets worse with time. AD is not a curable disease by any medication. It is impossible to halt the death of brain cells, but with the help of medication, the effects of AD can be delayed. As not all MCI patients will suffer from AD, it is required to accurately diagnose whether a mild cognitive impaired (MCI) patient will convert to AD (namely MCI converter MCI-C) or not (namely MCI non-converter MCI-NC), during early diagnosis. There are two modalities, positron emission tomography (PET) and magnetic resonance image (MRI), used by a physician for the diagnosis of Alzheimer’s disease. Machine learning and deep learning perform exceptionally well in the field of computer vision where there is a requirement to extract information from high-dimensional data. Researchers use deep learning models in the field of medicine for diagnosis, prognosis, and even to predict the future health of the patient under medication. This study is a systematic review of publications using machine learning and deep learning methods for early classification of normal cognitive (NC) and Alzheimer’s disease (AD).This study is an effort to provide the details of the two most commonly used modalities PET and MRI for the identification of AD, and to evaluate the performance of both modalities while working with different classifiers.