bluuebunny/crossref_metadata_2025_split huggingface dataset:
The digitalisation of finance management skills in dementia since the COVID-19 pandemic: A qualitative study
Authors: Giebel Clarissa , Halpin Kath , Tottie Jean , O’Connell Lena , Carton Joan 
Published: February 2023

Objectives Engaging with finances has become increasingly digitalised in recent years, particularly since the COVID-19 pandemic, yet it is unknown how finance management has been affected in people living with dementia. The aim of this qualitative study was therefore to explore how digitalisation and the recent pandemic have affected finance management skills in people with dementia. Methods Semi-structured interviews were conducted remotely with people with dementia and unpaid carers living in the UK via phone or Zoom between February and May 2022. Transcripts were coded by one of four different research team members, including two unpaid carers who were public advisers on the project. Data were analysed using inductive thematic analysis. Results Thirty carers and people with dementia participated, and five overarching themes were identified. Managing finances has been both simplified and made more complicated by digitalising how money is spent and managed, with people with dementia and unpaid carers reporting advantages of using direct debits and debit cards, as well as digital illiteracy barriers for older relatives with dementia. Unpaid carers have received no support in managing their relative’s finances, and were found to be burdened by the additional caring duties. Conclusions Carers need to be supported in managing their relative’s finances as well as with their general well-being due to taking on additional caring duties. Digital systems for finance management need to be user-friendly for people with cognitive impairment, with a need for digital literacy training for middle-aged and older adults to avoid difficulties if they develop dementia, and improved access to a computer/tablet/smart phone.
Disruption of COMMD1 accelerates diabetic atherosclerosis by promoting glycolysis
Authors: Zhang Lili , Li Lihua , Li Yalan , Jiang Han , Sun Zhen , Zang Guangyao , Qian Yongjiang , Shao Chen , Wang Zhongqun 
Published: February 2023

Aims Diabetes will lead to serious complications, of which atherosclerosis is the most dangerous. This study aimed to explore the mechanisms of diabetic atherosclerosis. Methods ApoE−/− mice were fed with an high-fat diet diet and injected with streptozotocin to establish an in vivo diabetic atherosclerotic model. RAW 264.7 cells were treated with oxidized low-density lipoprotein particles (ox-LDL) and high glucose to produce an in vitro diabetic atherosclerotic model. Results In this study, we showed that diabetes promoted the progression of atherosclerosis in ApoE−/− mice and that high glucose potentiates macrophage proinflammatory activation and foam cell formation. Mechanistically, Copper metabolism MURR1 domain-containing 1(COMMD1) deficiency increased proinflammatory activation and foam cell formation, characterized by increased glycolysis, and then accelerated the process of atherosclerosis. Furthermore, 2-Deoxy-D-glucose (2-DG) reversed this effect. Conclusion Taken together, we provided evidence that the lack of COMMD1 accelerates diabetic atherosclerosis via mediating the metabolic reprogramming of macrophages. Our study provides evidence of a protective role for COMMD1 and establishes COMMD1 as a potential therapeutic strategy in patients with diabetic atherosclerosis.
Isolated Tricuspid Valve Repair Versus Replacement: Predictors of Mortality on the National Level
Authors: Alnajar Ahmed , Arora Yingyot , Benck Kelley N. , Kabir Khan Abdul , Altabbakh Omar , Dar Tawseef , Lamelas Joseph 
Published: February 2023

Objective: Isolated tricuspid valve surgery (TVR) is rarely performed, and literature reports are confined to small sample sizes and old studies. Thus, the advantage of repair over replacement could not be determined. We aimed to evaluate repair and replacement outcomes along with predictors of mortality for TVR on a national level. Methods: All adult patients (18+ years old) who underwent TVR from 2011 to 2020 were identified using the National Inpatient Sample dataset. The primary outcome was in-hospital mortality. Secondary outcomes included complications, length of stay (LOS), hospitalization cost, and discharge disposition. Results: Over a 10-year period, 37,931 patients had TVR and predominantly underwent repair ( n = 25,027, 66.0%). In comparison with patients who underwent tricuspid replacement, more patients with a history of liver disease and pulmonary hypertension presented for repair surgery, and fewer patients had endocarditis and rheumatic valve disease ( P < 0.001). The repair group had less mortality, less stroke, shorter LOS, and reduced cost, while the replacement group had fewer myocardial infarctions ( P < 0.05). However, the outcomes were not different for cardiac arrest, wound complications, or bleeding. After excluding congenital TV disease and adjusting for relevant factors, TV repair was associated with a reduced in-hospital mortality by 28% (adjusted odds ratio [aOR] = 0.72, P = 0.011). Older age increased mortality risk by 3-fold, prior stroke by 2-fold, and liver diseases by 5-fold ( P < 0.001). Patients undergoing TVR in recent years had a better chance of survival (aOR = 0.92, P < 0.001). Conclusions: TV repair has better outcomes than replacement does. Patient comorbidities and late presentation play an independently significant role in determining outcomes.
A Nationwide Study of Clinical Outcomes After Robot-Assisted Coronary Artery Bypass Surgery and Hybrid Revascularization in the Netherlands
Authors: de Jong Anne R. , Gianoli Monica , Namba Hanae F. , Roefs Maaike M. , Singh Sandeep , Segers Patrique , Jacob Kirolos A. , Suyker Willem J.L. 
Published: February 2023

Objective: Robot-assisted minimally invasive direct coronary artery bypass (RA-MIDCAB) surgery and hybrid coronary revascularization (HCR) are minimally invasive alternative strategies to conventional coronary artery bypass surgery in patients with isolated left anterior descending (LAD) stenosis or multivessel coronary disease. We analyzed a large, multicenter data-set based on the Netherlands Heart Registration including all patients undergoing RA-MIDCAB. Methods: We included 440 consecutive patients who underwent RA-MIDCAB with the left internal thoracic artery to LAD between January 2016 and December 2020. A proportion of patients underwent percutaneous coronary intervention (PCI) of non-LAD vessels (i.e., HCR). The primary outcome was all-cause mortality at median follow-up of 1 year, which was subdivided into cardiac and noncardiac. Secondary outcomes included target vessel revascularization (TVR) at median follow-up as well as 30-day mortality, perioperative myocardial infarction, reoperation for bleeding or anastomosis-related problems, and in-hospital ischemic cerebrovascular accident (iCVA). Results: Among all patients, 91 (21%) underwent HCR. At median (IQR) follow-up of 19 (8 to 28) months, 11 patients (2.5%) had died. In 7 patients, the cause of death was defined as cardiac. TVR occurred in 25 patients (5.7%), of whom 4 underwent CABG and 21 underwent PCI. At 30-day follow-up, 6 patients (1.4%) had a perioperative myocardial infarction, of whom 1 died. One patient (0.2%) developed an iCVA, and 18 patients (4.1%) underwent reoperation for bleeding or anastomosis-related problems. Conclusions: The clinical outcomes of patients undergoing RA-MIDCAB or HCR in the Netherlands are good and promising when compared with the currently available literature.
The effect of operator's experience on mechanical thrombectomy outcomes: A systematic review
Authors: Dimitrios Xenos , Ghozy Sherief , Christina Charalampopoulou , Kolovoy Antonia , Ramanathan Kadirvel , Kallmes David F 
Published: February 2023

Background Mechanical thrombectomy (MT) has become the standard of care for stroke patients. The majority of the clinical trials and publications analyzing the outcomes related to the procedures report interventional performance by experienced practitioners. However, few of them individualize their preliminary metrics according to the operator's experience. Objective To summarize the literature and report safety and efficacy outcomes following MT procedures and correlate them with the operator's experience. Primary outcomes were successful recanalization, defined as modified thrombolysis in cerebral infarction greater or equal to 2b or 3, duration of the procedure measured in minutes, and serious adverse event. Methods This systematic review was performed according to the PRISMA guidelines. The PubMed, Embase, and Cochrane databases were utilized. Results There were six studies comprising 9348 patients (mean age 69.8 years; 51.2% males), and 9361 MT procedures were included. Each publication used for this review used a different experience definition to report their data. Higher interventionists’ experience demonstrated a positive relationship with the possibility of successful recanalization and an inverse relationship with the duration needed for the operation in almost all of the included studies. As for the complications, none of the authors reported a statistically significant risk reduction of an adverse event, except Olthuis et al. correlating increasing training with lower odds of stroke progression. Conclusions A higher experience level is associated with better recanalization rates and shorter procedural duration in MT operations. Further studies are warranted to define the minimum required level of experience for operational autonomy.
Factors affecting the acceptance of teledentistry determined using the technology acceptance model: A cross-sectional study
Authors: Bahanan Lina , Alsharif Maha 
Published: February 2023

Objective The aim of this pilot study is to identify the main predictors and barriers that influence user intention to adopt teledentistry services among the Saudi population. Methods A total of 426 respondents completed a questionnaire. Our study used the technology acceptance model to predict how users will adopt teledentistry. An analysis of the factors that influence patient users’ intention to utilize teledentistry was conducted using partial least square structural equation modeling. Results Among the factors that influenced the intention to use teledentistry services, social influence positively affected the intention (β = 0.18, t = 2.19, p-value = 0.03), whereas perceived risk negatively affected it (β = −0.21, t = 2.69, p-value =0.01). Conclusion The perception of risk was a major barrier to the adoption of teledentistry services, while social influence was a significant positive predictor. Using the findings of the study, policymakers and health service providers can gain a better understanding of the factors influencing the implementation of teledentistry.
Gender and Racial Diversity Among the Head Medical and Athletic Training Staff of Women’s Professional Sports Leagues
Authors: Wilson Jasmin , Agha Obiajulu , Wiggins Anthony J. , Diaz Agustin , Jones Kristofer J. , Feeley Brian T. , Pandya Nirav K. , Wong Stephanie E. 
Published: February 2023

Background: Despite increased awareness for promoting diversity, orthopaedics remains one of the least diverse specialties. Studying health care providers in women’s professional sports provides a unique opportunity to analyze gender and racial diversity. Hypotheses: There would be low female and minority representation across the various women’s professional sports leagues. There would be an increased number of female head certified athletic trainers (ATCs) when compared with head team physicians (HTPs). Study Design: Cross-sectional study. Methods: We evaluated the perceived race and sex of designated HTPs and ATCs in the Women’s National Basketball Association, National Women’s Soccer League, and National Women’s Hockey League. Type of doctorate degree, specialty, and years in practice were also collected. Kappa (κ) coefficient measurements were used to determine interobserver agreement on race. Categorical and continuous variables were analyzed using chi-square and t tests, respectively. Results: There were significantly more female ATCs than female HTPs (74.1% vs 37.5%; P = .01). Minority representation between HTPs and ATCs was not significantly different (20.8% vs 40.7%; P = .13). Black HTPs (12.5%) and Black ATCs (22.2%) composed the largest proportion among the minority groups. There was high interobserver agreement of perceived race across HTPs (κ = 1.0) and ATCs (κ = 0.95). Conclusion: Although there were more female ATCs than HTPs in women’s professional sports leagues, both cohorts lack perceived racial diversity. These data suggest an opportunity for diversification in medical and training staff of women’s professional sports.
Politically Engaged Mindset of Everyday Coping in Relation to Nursing Values: A Phenomenological-Hermeneutic Study of District Nurses’ Experiences
Authors: Hauan Marianne , Kvigne Kari , Alteren Johanne 
Published: February 2023

Introduction To accommodate challenges threatening the healthcare sector's sustainability, district nursing in Norway implemented the rehabilitative and health promoting mindset of everyday coping. When implementing new ideas and practices in nursing care, understanding the significance of this mindset on patient care and whether it corresponds to nursing values are important to ensure healthcare quality. Objective This study aimed to understand how nurses practice care where everyday coping is implemented in district nursing and their experience of everyday coping as a mindset in relation to nursing values. Methods A qualitative study was conducted including 19 observations and 19 narrative interviews with 10 district nurses, during two data collection periods. Data were analyzed using a phenomenological-hermeneutic method. The analysis process consisted of three steps: naïve reading, structural analysis, and comprehensive understanding. Results The following two main themes and four sub-themes emerged from the data analyses: (i) Understanding individual patient situations; “Creating a nurse–patient relationship to understand the patient landscape” and “providing care based on individual patient needs,” (ii) knowing when and how to motivate or help patients; “distinction between motivating patients and causing stress” and “realistic and desirable demands to motivate patients to perform tasks.” Conclusion Participants determined how to provide care to patients based on their values, professional knowledge, and individual patient situations. The patient landscape is diverse and everyday coping is unable to capture the diversity of patient groups. Thus, everyday coping is not expressed as an overall mindset in nursing practice.
Standardized Nursing Diagnoses in a Surgical Hospital Setting: A Retrospective Study Based on Electronic Health Data
Authors: Cesare Manuele , D’agostino Fabio , Maurici Massimo , Zega Maurizio , Zeffiro Valentina , Cocchieri Antonello 
Published: February 2023

Introduction In electronic health records (EHRs), standardized nursing terminologies (SNTs), such as nursing diagnoses (NDs), are needed to demonstrate the impact of nursing care on patient outcomes. Unfortunately, the use of NDs is not common in clinical practice, especially in surgical settings, and is rarely included in EHRs. Objective(s) The aim of the study was to describe the prevalence and trend of NDs in a hospital surgical setting by also analyzing the relationship between NDs and hospital outcomes. Methods A retrospective study was conducted. All adult inpatients consecutively admitted to one of the 15 surgical inpatient units of an Italian university hospital across 1 year were included. Data, including the Professional Assessment Instrument and the Hospital Discharge Register, were collected retrospectively from the hospital's EHRs. Results The sample included 5,027 surgical inpatients. There was a mean of 6.3 ± 4.3 NDs per patient. The average distribution of NDs showed a stable trend throughout the year. The most representative NANDA-I ND domain was safety/protection. The total number of NDs on admission was significantly higher for patient whose length of stay was longer. A statistically significant correlation was observed between the number of NDs on admission and the number of intra-hospital patient transfers. Additionally, the mean number of NDs on admission was higher for patients who were later transferred to an intensive care unit compared to those who were not transferred. Conclusion NDs represent the key to understanding the contribution of nurses in the surgical setting. NDs collected upon admission can represent a prognostic factor related to the hospital's key outcomes.
Predictors of Nurses’ Practice of Eye Care for Patients in Intensive Care Units
Authors: Lami Sana , Ayed Ahmad 
Published: February 2023

Introduction Taking care of patients’ eyes is an important nursing skill. Nurses must be capable of providing a standard assessment of the eye and vision as well as necessary care such as eye cleaning. Intensive care unit (ICU) nurses typically focus on life-threatening issues while giving little attention to other serious issues. The purpose of this study was to assess predictors of nurses’ practice of eye care for patients in ICUs in the West Bank. Method A cross-sectional study was conducted with all ICU nurses from West Bank hospitals. The researchers developed a self-administered questionnaire to collect data. Results One hundred and fifty-two nurses participated in this study. The findings revealed that the mean age of nurses was 31.2 ( SD  =  7.5) years. The analysis revealed that only 0.7% had a good knowledge level, 7.2% had a fair knowledge level, and 25.7% had a good practice level of eye care for patients in an ICU. Knowledge of patients’ eye care in the ICU, as well as an eye care protocol or policy for unconscious patients, was found to be significant predictors of practice ( p < .001). Conclusion The study confirmed that the nurses had poor knowledge and inadequate practice of eye care for patients in the ICU. Also, the study confirmed that a nurse's knowledge of patients’ eye care in the ICU and an eye care protocol or policy for unconscious patients were significant predictors of practice.
RBM15 suppresses hepatic insulin sensitivity of offspring of gestational diabetes mellitus mice via m6A-mediated regulation of CLDN4
Authors: Fang Jie , Wu Xiafei , He Jie , Zhang Hanwen , Chen Xuyang , Zhang Hua , Novakovic Boris , Qi Hongbo , Yu Xinyang 
Published: February 2023

Abstract
Background
Gestational diabetes Mellitus (GDM) is a common pregnancy-specific disease with high morbidity, which is linked to a high risk of obesity and diabetes in offspring. N6-methyladenosine modification of RNA is emerging as an important epigenetic mechanism that is widely manifested in many diseases. This study aimed to investigate the mechanism of m6A methylation in metabolic syndrome in offspring result from intrauterine hyperglycemia.

Methods
GDM mice were established by feeding a high-fat diet 1 weeks before pregnancy. The m6A RNA methylation quantification kit was used to detect liver tissue methylation levels. PCR array was used to determine the expression of the m6A methylation modification enzyme. Immunohistochemistry, qRT-PCR, and western blot were used to examine the expression of RBM15, METTL13, IGF2BP1, and IGF2BP2. Subsequently, methylated RNA immunoprecipitation sequencing combined with mRNA sequencing, followed by dot blot and glucose uptake tests, were performed.

Results
In this study, we found that offspring from a GDM mother were more vulnerable to glucose intolerance and insulin resistance. GC–MS revealed significant metabolic changes including saturated fatty acids and unsaturated fatty acids in liver of GDM offspring. We also demonstrated that global mRNA m6A methylation level was significantly increased in the fetal liver of GDM mice, indicating epigenetic change may have a strong relationship with the mechanism of metabolism syndrome. Concordantly, RBM15, the RNA binding methyltransferase, was upregulated in the liver. In vitro, RBM15 suppressed insulin sensitivity and increased insulin resistance through m6A-regulated epigenetic inhabitation of CLDN4. Moreover, MeRIP-sequencing and mRNA-sequencing revealed that differently regulated genes with differential m6A peaks were enriched in metabolic pathways.

Conclusion
Our study revealed the essential role of RBM15 in insulin resistance and the effect of RBM15-regulated m6A modification in the metabolic syndrome of offspring of GDM mice.
Properties and alcohol sensing applications of quasi-2D (PEA)2(MA)3Sb2Br9 thin films
Authors: Hun Chien-Min , Chen Lung-Chien 
Published: February 2023

AbstractWe fabricated an alcohol detector based on (PEA)2(CH3NH3)3Sb2Br9 ((PEA)2MA3Sb2Br9) lead-free perovskite-like films. The XRD pattern revealed that the (PEA)2MA3Sb2Br9 lead-free perovskite-like films exhibited a quasi-2D structure. The optimal current response ratios are 74 and 84 for 5 and 15% alcohol solutions, respectively. When the amount of PEABr decreases in the films, the conductivity of the sample in ambient alcohol with a high alcohol concentration solution increases. The alcohol was dissolved into water and carbon dioxide due to the catalyst effect of the quasi-2D (PEA)2MA3Sb2Br9 thin film. The rise and fall times for the alcohol detector were 1.85 and 0.7 s, respectively, indicating that the detector was suitable.
Stroke-like manifestation of a spontaneous spinal epidural hematoma with spontaneous resolution: a case report
Authors: Na Xue Bi, May , Khoo Swee Min, Kathleen 
Published: February 2023

Abstract
Background
This case report presents the case of a man with no known coagulopathy or preceding trauma, who spontaneously developed a spinal epidural hematoma (SEH). This is an uncommon condition which can have variable presentations including hemiparesis mimicking stroke, resulting in the potential for misdiagnosis and inappropriate treatment.

Case presentation
A 28-year-old Chinese male with no past medical history presented with sudden onset neck pain associated with bilateral upper limbs and right lower limb subjective numbness but intact motor function. He was discharged after adequate pain relief but re-attended the emergency department with right hemiparesis. A magnetic resonance imaging of his spine revealed an acute cervical spinal epidural hematoma at C5 and C6. While admitted, he had spontaneous improvement of his neurological function and was eventually managed conservatively.

Conclusions
SEH, although uncommon, can be a mimic of stroke and it is important to avoid misdiagnosis as it is a time critical diagnosis, and administration of thrombolysis or antiplatelets can lead to unfavourable outcomes. Having a high clinical suspicion can help to guide us in the choice of imaging and interpretation of subtle signs to reach the correct diagnosis in a timely manner. Further research is required to better understand the factors that would favour a conservative approach as opposed to surgical treatment.