bluuebunny/crossref_metadata_2025_split huggingface dataset:
Malaria Infections and Placental Blood Flow: A Doppler Ultrasound Study From a Preconception Cohort in Benin
Authors: Mondeilh Aude , Yovo Emmanuel , Accrombessi Manfred , Hounkonnou Cornelia , Agbota Gino , Atade William , Ladikpo Olaiitan T , Mehoba Murielle , Degbe Auguste , Vianou Bertin , Sossou Dariou , Ndam Nicaise Tuikue , Massougbodji Achille , McGready Rose , Fievet Nadine , Rijken Marcus J , Cottrell Gilles , Briand Valérie 
Published: August 2023

AbstractBackgroundMalaria in pregnancy (MiP) has been associated with fetal growth restriction, the underlying pathogenic mechanisms of which remain poorly understood. Malaria in pregnancy is suspected to induce abnormalities in placental vascularization, leading to impaired placental development. Our study evaluated MIP's effect on uterine artery (UtA) and umbilical artery (UA) blood flow.MethodsThe analysis included 253 Beninese women followed throughout pregnancy and screened monthly for submicroscopic and microscopic malaria. Uterine artery Doppler measurement was performed once between 21 and 25 weeks’ gestation (wg), and UA Doppler measurement was performed 1–3 times from 28 wg. Linear and logistic regression models were used to assess the effect of malaria infections on UtA Doppler indicators (pulsatility index and presence of a notch), whereas a logistic mixed model was used to assess the association between malaria infections and abnormal UA Doppler (defined as Z-score ≥2 standard deviation or absent/reversed UA end-diastolic flow).ResultsPrimigravidae represented 7.5% of the study population; 42.3% of women had at least 1 microscopic infection during pregnancy, and 29.6% had at least 1 submicroscopic infection (and no microscopic infection). Both microscopic and submicroscopic infections before Doppler measurement were associated with the presence of a notch (adjusted odds ratio [aOR] 4.5, 95% confidence interval [CI] = 1.2–16.3 and aOR 3.3, 95% CI = .9–11.9, respectively). No associations were found between malaria before the Doppler measurement and abnormal UA Doppler.ConclusionsMalaria infections in the first half of pregnancy impair placental blood flow. This highlights the need to prevent malaria from the very beginning of pregnancy.
The Penn Medicine COVID-19 Therapeutics Committee—Reflections on a Model for Rapid Evidence Review and Dynamic Practice Recommendations During a Public Health Emergency
Authors: Anesi George L , Degnan Kathleen , Dutcher Lauren , Saw Stephen , Maguire Christina , Binkley Amanda , Patel Sonal , Athans Vasilios , Barton Todd D , Binkley Shawn , Candeloro Christina L , Herman David J , Kasbekar Nishaminy , Kennedy Leigh , Millstein Jeffrey H , Meyer Nuala J , Talati Naasha J , Patel Hinal , Pegues David A , Sayre Patrick J , Tebas Pablo , Terico Adrienne T , Murphy Kathleen M , O’Donnell Judith A , White Melissa , Hamilton Keith W 
Published: August 2023

Abstract
The Penn Medicine COVID-19 Therapeutics Committee—an interspecialty, clinician-pharmacist, and specialist–front line primary care collaboration—has served as a forum for rapid evidence review and the production of dynamic practice recommendations during the 3-year coronavirus disease 2019 public health emergency. We describe the process by which the committee went about its work and how it navigated specific challenging scenarios. Our target audiences are clinicians, hospital leaders, public health officials, and researchers invested in preparedness for inevitable future threats. Our objectives are to discuss the logistics and challenges of forming an effective committee, undertaking a rapid evidence review process, aligning evidence-based guidelines with operational realities, and iteratively revising recommendations in response to changing pandemic data. We specifically discuss the arc of evidence for corticosteroids; the noble beginnings and dangerous misinformation end of hydroxychloroquine and ivermectin; monoclonal antibodies and emerging viral variants; and patient screening and safety processes for tocilizumab, baricitinib, and nirmatrelvir-ritonavir.
Prevalence and influencing factors of depressive and anxiety symptoms among hospital-based healthcare workers during the surge period of the COVID-19 pandemic in the Chinese mainland: a multicenter cross-sectional study
Authors: Jing S , Dai Z , Wu Y , Liu X , Ren T , Liu X , Zhang L , Fu J , Chen X , Xiao W , Wang H , Huang Y , Qu Y , Wang W , Gu X , Ma L , Zhang S , Yu Y , Li L , Han Z , Su X , Qiao Y , Wang C 
Published: August 2023

Summary

Background
From November 2022 to February 2023, the Chinese mainland experienced a surge in COVID-19 infection and hospitalization, and the hospital-based healthcare workers (HCWs) might suffer serious psychological crisis during this period. This study aims to assess the depressive and anxiety symptoms among HCWs during the surge of COVID-19 pandemic and to provide possible reference on protecting mental health of HCWs in future infectious disease outbreaks.

Methods
A multicenter cross-sectional study was carried out among hospital-based HCWs in the Chinese mainland from 5 January to 9 February 2023. The PHQ-9 (nine-item Patient Health Questionnaire) and GAD-7 (seven-item Generalized Anxiety Disorder Questionnaire) were used to measure depressive and anxiety symptoms. Ordinal logistic regression analysis was performed to identify influencing factors.

Results
A total of 6522 hospital-based HCWs in the Chinse mainland were included in this survey. The prevalence of depressive symptoms among the HCWs was 70.75%, and anxiety symptoms was 47.87%. The HCWs who perceived higher risk of COVID-19 infection and those who had higher work intensity were more likely to experience depressive and anxiety symptoms. Additionally, higher levels of mindfulness, resilience and perceived social support were negatively associated with depressive and anxiety symptoms.

Conclusion
This study revealed that a high proportion of HCWs in the Chinese mainland suffered from mental health disturbances during the surge of the COVID-19 pandemic. Resilience, mindfulness and perceived social support are important protective factors of HCWs’ mental health. Tailored interventions, such as mindfulness practice, should be implemented to alleviate psychological symptoms of HCWs during the COVID-19 pandemic or other similar events in the future.
Cash Is King: The Role of Financial Infrastructure in Digital Adoption
Authors: Aggarwal Bhavya , Kulkarni Nirupama , Ritadhi S K 
Published: August 2023

AbstractThis paper examines whether a one-time, extensive, but temporary shock to cash supply can affect the adoption of digital payments. We exploit the 2016 demonetization episode in India, which overnight discontinued 86% of cash in circulation. Using novel administrative data from retail debit card transactions, we identify a 12% increase in digital payments in areas adversely affected by the cash shortage, which persisted well after the restoration of cash supply. Examining mechanisms, we find a limited role for social networks and stronger support for learning by doing. Further, information frictions hinder the immediate adoption of digital payments. (JEL E5, 023)Authors have furnished an Internet Appendix, which is available on the Oxford University Press Web site next to the link to the final published paper online.
Funding Contagion through Common Owners
Authors: Larrain Borja , Sertsios Giorgo , Urzúa I Francisco 
Published: August 2023

Abstract
Funding contagion is the impaired ability of a firm to raise external funds when negative shocks hit other firms under the same owner. We study this possibility with pairs of private firms in unrelated industries that share a large common shareholder. We find that a firm’s debt growth and financial leverage go down when the partner firm experiences negative shocks. Our results are consistent with creditors contracting the credit supply because of cash flow cross-pledging between related firms. Funding contagion increases when control rights are strong, and the credit market is less developed. (JEL G30, G32)
Received: February 17, 2021; Editorial decision: July 18, 2023 by Editor: Andrew Ellul. Authors have furnished an Internet Appendix, which is available on the Oxford University Press Web site next to the link to the final published paper online.
E07 Development of a coordinated transitional care program on adolescents with juvenile idiopathic arthritis: looking through the patient lens
Authors: Miedany Yasser El , Abu-Zaid Mohammed Hassan , Eissa Mervat , Hassan Waleed A , Mortada Mohamed , Tabra Samar Abd Alhamed , Mohamed Sally S , Maher Sheren Esam , Gaafary Maha El , Medhat Basma M , Mosa Doaa Mosad , Fouad Nermeen Ahmed , Amer Youmna Ahmed , Nasef Samah Ismail , Shalaby Radwa H , Adel Yasmin , Elkhalek Reham Abd , Mahgoub Marwa Yahia , Lotfy Hala M 
Published: August 2023

Abstract

Background
Transition of care means the process of educating and empowering adolescents and young adults to take an active role in their own healthcare, develop decision-making skills, and eventually transition from paediatric to adult healthcare providers. Most people don't switch doctors until they are young adults, but it can be beneficial to start preparing children earlier.

Objectives
To provide a toolset specifically suited for adult and paediatric rheumatologists to help them transition the care of children with rheumatic diseases from adult to paediatric rheumatology care.

Methods
The preliminary scientific committee identified a total of ten major clinical questions in this study, which was conducted to obtain expert consensus. To reach consensus on the transition of care for young adults and adolescents with rheumatic diseases, the core leadership team sought out researchers and clinicians with expertise in both paediatric and adult rheumatic diseases management.

Results
The expert panel's participation was restricted to an online survey (n = 18); each expert completed both rounds. After round 2, a total of 10 points had been collected. 88.9% to100% of respondents (ranks 7–9) indicated they agreed with the recommendations. The scientific committee's 10 clinical standards were all prepared in the same style. A structured template describing the integrated pathway for transition of care was developed using the responses to the structured key questions and the results of the literature review.

Conclusion
The created rheumatology-specific guideline provides young adults with juvenile rheumatic diseases with a focused, multidisciplinary transition of care strategy with equity of access, quality of care, and flexibility and establishes standards for transitional care.

Ethics
This study was performed in accordance with the Helsinki Declaration. The ‘Clinical, Evidence-based, Guidelines’ (CEG) initiative protocol was approved the local ethical committee: ethical approval code: 34842/8/21, ethical board Tanta University.
E16 Extra-articular manifestations and hip involvement in juvenile idiopathic arthritis: what is the link?
Authors: Rahmouni Safa , Tbini Houssem , Rekik Sonia , Ben Ammou Ahlem , Zouaoui Khaoula , Boussaid Soumaya , Sahli Hela , Elleuch Mohammed 
Published: August 2023

Abstract

Introduction
Juvenile idiopathic arthritis (JIA) is a complex pediatric rheumatism. The systemic and structural involvement of the disease is both functional and life threatening. Hip involvement can reach 50% of cases, especially in severe and destructive cases.

Objectives
The objective of this work is to study the relationship between systemic and hip involvement in JIA.

Methods
This was a retrospective study including adults with long-standing JIA according to the International League of Associations for Rheumatology (ILAR) criteria over a period of 28 years (1994–2022). Socio-demographic, clinical, biological, and radiographic data were collected.

Results
There were 29 patients (17 females and 12 males), the mean age was 35.69 ± 11.72 [18–61] years. The mean age of disease onset was 11.10 ± 4.25 [2–16] years. The average diagnostic delay was 52.96 ± 95.97 [0–336] months. The average disease duration was 24.48 ± 12.76 [1–47] years.
At least one extra-articular manifestation was noted in 20 patients. An ocular dry syndrome was present in 6 cases, with a delay of onset of 132.14 ± 134.18 [0–312] months.
Skin involvement was present in 4 cases with a mean onset delay of 24.25 ± 47.83 [0–96] months. Three patients had a pulmonary interstitial syndrome, the onset delay of this pulmonary involvement was 228.00 ± 74.94 [0–312] months. Valvular involvement was present in 3 cases and pericarditis in only one case, the onset delay of cardiac involvement was 211.33 ± 129.40 [70–324] months. Renal involvement was noted in 2 cases: one case of proteinuria and one case of renal failure, the time of onset of renal involvement was 12.50 ± 16.26 [1–24] months. Furthermore, hematological damage such as anaemia was noted in 20 of the patients included. No patients had macrophage activation syndrome in our study population.
Hip involvement was noted in 14 patients. It was bilateral in 9 cases. Twenty-three hips were affected in total. Hip involvement was diagnosed 14.5 ± 9.37 [1–28] years after disease onset.
Our statistical study identified a single correlation between hip involvement and cardiac involvement during JIA (r = 0.413; P = 0.026).
In contrast, no other correlation was identified between hip involvement and the rest of the extra-articular involvement in JIA.

Conclusion
Extra-articular and hip involvements are common in JIA. Both have a prognostic impact and must be systematically screened throughout the follow-up. In our study, hip involvement was correlated with cardiac involvement.
E25 The pattern of juvenile psoriatic arthritis in a tertiary centre in Libya
Authors: Hashad Soad S , Etayari Hala M , Almsellati Iman A , Etfil Majda N , Altwati Aya , Awhida Zuhaira 
Published: August 2023

Abstract

Background
Juvenile psoriatic arthritis (JPsA) is a relatively rare condition in childhood as it represents ∼5% of the whole Juvenile Idiopathic Arthritis (JIA). There are fewer reports describing the characteristics and outcome of patients with JPsA.

Aim
To describe the characteristic features and the treatment modalities of JPsA among Libyan children in pediatric rheumatology clinic at the Tripoli Children Hospital which is the only referral clinic covering the western, northern and southern part of Libya and to compare our results with other populations worldwide.

Methods
All the medical records of the children who were diagnosed to have JPsA according to ILAR classification criteria or Vancouver criteria (definite or probable) from January 2001 to January 2020 were included and retrospectively reviewed. Data were collected about demographic, clinical, and laboratory features and treatment

Results
The study included a total of 30 cases of JPsA that represents a 12% of total JIA cases over the study period, the mean age at presentation was 5.8 ± 5.3 years with male to female ratio of 1:1, with the mean duration of symptoms prior to diagnosis of JIA of 9 ± 10 months.
The foremost common type of arthritis was peripheral polyarthritis (83% & 58.3%), with the Small joints commonly affected, 30% of patients had hip joint involvement.
13% of the patient had psoriasis, half of them before presentation of arthritis. Nail changes secondary to psoriasis was seen in 1 of the cohort, and the percentage of patients with dactylitis among the group was 30%.
Family history of psoriasis found in 83% of the cohort, 26% found to be ANA positive. Chronic uveitis occurred in 10%. Patients of the total cohort, ANA positive, Unilateral anterior uveitis being the most common presentation.
The following table summarizes the Medications used during the course of the disease
At the time of the first visit 100%of total patients fulfilled the Vancouver criteria for juvenile PsA, While 5 of the12 patients didn’t fulfilled the ILAR criteria for JPsA.

Conclusions
Juvenile psoriatic arthritis constituted 12% of our patients with juvenile idiopathic arthritis. Juvenile psoriatic arthritis constitutes 8% to20% of JIA patients worldwide with equal gender distribution and peak age at presentation of 6–13 years. More than four peripheral joints involvement were the most frequent presentation. Half of the patients had skin involvement before the development of arthritis. Prevalence of chronic anterior uveitis was higher in our cohort than worldwide (10% vs 5% respectively) as an extra articular manifestation. All patients were treated with NSAIDs at presentation and/or during follow-up. Methotrexate was the most commonly used second-line agent

Ethics
Our study was approved by local ethical committee of pediatric department at Tripoli children hospital.
E27 Performance of systemic juvenile idiopathic arthritis classification criteria: one-centre experience—Libya
Authors: Hashad Soad S , Etayari Hala M , Almsellati Iman A , Etfil Majda N , Altwati Aya , Awhida Zuhaira 
Published: August 2023

Abstract

Systemic juvenile idiopathic arthritis (sJIA) constitutes a small part of juvenile idiopathic arthritis (JIA), yet has a disproportionally higher rate of mortality. In comparison to the other (JIA), systemic juvenile idiopathic arthritis has many distinct clinical features that arthritis may be a non-prominent and/or a delayed manifestation. The Pediatric Rheumatology International Trial Organization (PRINTO), currently is developing a new criterion for JIA classification which will allow for better identification of sJIA cases with delayed onset of arthritis and fail to fulfil the currently used International League Against Rheumatism (ILAR) and Yamaguchi criteria. It is useful in classification of children with systemic juvenile idiopathic arthritis (sJIA) particularly in ‘pre-arthritic’, pure systemic phase of the illness.

Objectives
The purpose of this study is to compare the performances of the Yamaguchi diagnostic criteria vs PRINTO criteria vs current ILAR criteria for systemic juvenile idiopathic arthritis. We compared the proportions of patients classified and how closely the 3 instruments are related.

Methods
The study was performed at the Department of Paediatric Rheumatology in Tripoli children hospital. It is a retrospective study, covering the date range 2006–2020. We used clinicobiologic data recorded within 7 months of diagnosis of Patients diagnosed with sJIA. We assigned a diagnosis of sJIA according to the 3 sJIA classification systems (the Yamaguchi diagnostic criteria, PRINTO criteria and according to ILAR classification).

Results
Three different classification criteria were analysed in 38 assigned sJIA children (13% of total JIA cases). Females were 28 (52.6%), and mean age of JIA onset was 7 ± 3.9 yr. The mean of the time delay between disease onset and diagnosis was 7 ± 9 months. Overall, the ILAR and PRINTO criteria were fulfilled in a higher number of patients in the study (n = 35) (92% of patients), As compared with the Yamaguchi criteria (n = 29).(76% of patients). Among the 7.9% patients who were unclassifiable using the ILAR criteria were diagnosed as sJIA by both the PRINTO and the Yamaguchi diagnostic criteria. 7.89% neither fulfilled the Yamaguchi or the PRINTO Criteria. The table below compares the performance of the three different criteria.

Conclusions
In this cohort the ILAR criteria appear to be superior in the early recognition and classification of sJIA. Yamaguchi diagnostic criteria can only be used to classify a minority of sJIA patients, leaving a large proportion of sJIA patients unclassified. Compared with the Yamaguchi criteria, ILAR JIA categories aligned better with PRINTO criteria. All the criteria should incorporate strengths of each other.

Ethics
Our study was approved by local ethical committee of pediatric department at Tripoli children hospital.
E41 PAPA Syndrome: response to methotrexate in four members of the same family
Authors: Slimani Samy , Hadef Djohra , Ghodbane Nacif Eddine 
Published: August 2023

Abstract

Introduction
PAPA syndrome (Pyogenic Arthritis, Pyoderma gangrenosum and Acne) is a rare autosomal dominant disease that mainly affects the joints and skin. It is linked to a mutation of a gene of a protein named PSTPIP1 located on chromosome 15q. Arthritis is destructive, oligoarticular and predominantly affects large joints. It usually begins during childhood and not responsive to most treatments. The diagnosis is late and arises with infectious arthritis, given the destructive and pyogenic nature of arthritis and biological inflammatory syndrome.

Aim
We describe the cases of four members of the same family affected by PAPA syndrome who were treated empirically with long-term corticosteroids and then methotrexate to improve their joint involvement.

Case reports
We report the cases of 4 male patients belonging to the same large family (3 brothers and a first cousin), aged 28, 23, 21 and 15 years (patients 1–4, classified by age), affected by PAPA syndrome who presented with recurrent osteoarticular infections treated with antibiotics. They have no other conditions except vitiligo in patient 1 and Down syndrome in patient 3. Diagnosis was made in patient 1 based on joint and skin involvement. Other family members were subsequently called for diagnostic evaluation. A treatment combining methotrexate (10–15 mg/week) and corticosteroids (5 mg/day of prednisolone weaned and discontinued after 6–12 months of initiation) was associated with clinical and biological response in all patients with a decrease in pain, clinical and ultrasound improvement of synovitis and normalization of biological inflammatory markers in all four cases. Methotrexate was well tolerated and maintained as monotherapy, associated with on demand NSAIDs. The current average follow-up is 2.3 years.

Conclusion
Through our observations, we report a possible beneficial effect and good tolerance of methotrexate on joint involvement in PAPA syndrome. A more rigorous study (larger sample size, control arm) is necessary to validate this treatment.
Robustness of Felsenstein’s Versus Transfer Bootstrap Supports With Respect to Taxon Sampling
Authors: Zaharias Paul , Lemoine Frédéric , Gascuel Olivier 
Published: August 2023

Abstract
The bootstrap method is based on resampling sequence alignments and re-estimating trees. Felsenstein’s bootstrap proportions (FBP) are the most common approach to assess the reliability and robustness of sequence-based phylogenies. However, when increasing taxon sampling (i.e., the number of sequences) to hundreds or thousands of taxa, FBP tend to return low support for deep branches. The transfer bootstrap expectation (TBE) has been recently suggested as an alternative to FBP. TBE is measured using a continuous transfer index in [0,1] for each bootstrap tree, instead of the binary {0,1} index used in FBP to measure the presence/absence of the branch of interest. TBE has been shown to yield higher and more informative supports while inducing a very low number of falsely supported branches. Nonetheless, it has been argued that TBE must be used with care due to sampling issues, especially in datasets with a high number of closely related taxa. In this study, we conduct multiple experiments by varying taxon sampling and comparing FBP and TBE support values on different phylogenetic depths, using empirical datasets. Our results show that the main critique of TBE stands in extreme cases with shallow branches and highly unbalanced sampling among clades, but that TBE is still robust in most cases, while FBP is inescapably negatively impacted by high taxon sampling. We suggest guidelines and good practices in TBE (and FBP) computing and interpretation.