bluuebunny/crossref_metadata_2025_split huggingface dataset:
Central government role in road infrastructure development and economic growth in the form of future study: the case of Indonesia
Authors: Nawir Daud , Bakri Muhammad Djaya , Syarif Iif Ahmad 
Published: April 2023

AbstractRoad infrastructure development in a country has been considered an important predictor of economic development and prosperity. Hence applying a systematic analysis approach, this study aims to project the future role of the central government in developing road infrastructure and its significance in the country's economic growth. The main data sources were the literature review and expert opinions in the form of self-administrative surveys and interviews. Besides, the Cross-impact Direct Influence (CDI) matrix was applied to formulate the questionnaire. For the data analysis purpose, MICMAC analysis and Scenario Wizard software were used. The MICMAC analysis results revealed the dominant role of 9 important/key variables in developing the Indonesian road infrastructure. Simultaneously 24 positive states of the important variables what identified via the Scenario-Wizard Method. Findings also depicted stronger consistency among the four scenarios. Whereas Scenario 1 showed the most ideal 9 key features related to Indonesia’s road infrastructure developments with a high intensity of concentrating the efforts on planning road infrastructure development in big cities and use of smart and modern technology. Moreover, presenting a group of constructs for developing road infrastructure and resultant economic growth in the country, the current study adds value to the existing literature.
Zebrafish ambra1b knockout reveals a novel role for Ambra1 in primordial germ cells survival, sex differentiation and reproduction
Authors: Fontana Camilla Maria , Terrin Francesca , Facchinello Nicola , Meneghetti Giacomo , Dinarello Alberto , Gambarotto Lisa , Zuccarotto Annalisa , Caichiolo Micol , Brocca Ginevra , Verin Ranieri , Nazio Francesca , Carnevali Oliana , Cecconi Francesco , Bonaldo Paolo , Dalla Valle Luisa 
Published: April 2023

Abstract
Background
AMBRA1 is an intrinsically disordered protein, working as a scaffold molecule to coordinate, by protein-protein interaction, many cellular processes, including autophagy, mitophagy, apoptosis and cell cycle progression. The zebrafish genome contains two ambra1 paralogous genes (a and b), both involved in development and expressed at high levels in the gonads. Characterization of the zebrafish paralogous genes mutant lines generated by CRISPR/Cas9 approach showed that ambra1b knockout leads to an all-male population.

Results
We demonstrated that the silencing of the ambra1b gene determines a reduction of primordial germ cells (PGCs), a condition that, in the zebrafish, leads to the development of all-male progeny. PGC reduction was confirmed by knockdown experiments and rescued by injection of ambra1b and human AMBRA1 mRNAs, but not ambra1a mRNA. Moreover, PGC loss was not rescued by injection with human AMBRA1 mRNA mutated in the CUL4-DDB1 binding region, thus suggesting that interaction with this complex is involved in PGC protection from loss. Results from zebrafish embryos injected with murine Stat3 mRNA and stat3 morpholino suggest that Ambra1b could indirectly regulate this protein through CUL4-DDB1 interaction. According to this, Ambra1+/− mice showed a reduced Stat3 expression in the ovary together with a low number of antral follicles and an increase of atretic follicles, indicating a function of Ambra1 in the ovary of mammals as well. Moreover, in agreement with the high expression of these genes in the testis and ovary, we found significant impairment of the reproductive process and pathological alterations, including tumors, mainly limited to the gonads.

Conclusions
By exploiting ambra1a and ambra1b knockout zebrafish lines, we prove the sub-functionalization between the two paralogous zebrafish genes and uncover a novel function of Ambra1 in the protection from excessive PGC loss, which seems to require binding with the CUL4-DDB1 complex. Both genes seem to play a role in the regulation of reproductive physiology.
Key issues for stakeholder engagement in the development of health and healthcare guidelines
Authors: Petkovic Jennifer , Magwood Olivia , Lytvyn Lyubov , Khabsa Joanne , Concannon Thomas W. , Welch Vivian , Todhunter-Brown Alex , Palm Marisha E. , Akl Elie A. , Mbuagbaw Lawrence , Arayssi Thurayya , Avey Marc T. , Marusic Ana , Morley Richard , Saginur Michael , Slingers Nevilene , Texeira Ligia , Ben Brahem Asma , Bhaumik Soumyadeep , Bou Akl Imad , Crowe Sally , Dormer Laura , Ekanem Comfort , Lang Eddy , Kianzad Behrang , Kuchenmüller Tanja , Moja Lorenzo , Pottie Kevin , Schünemann Holger , Tugwell Peter 
Published: April 2023

AbstractEstablished in 2015, the Multi-Stakeholder Engagement (MuSE) Consortium is an international network of over 120 individuals interested in stakeholder engagement in research and guidelines. The MuSE group is developing guidance for stakeholder engagement in the development of health and healthcare guideline development. The development of this guidance has included multiple meetings with stakeholders, including patients, payers/purchasers of health services, peer review editors, policymakers, program managers, providers, principal investigators, product makers, the public, and purchasers of health services and has identified a number of key issues. These include: (1) Definitions, roles, and settings (2) Stakeholder identification and selection (3) Levels of engagement, (4) Evaluation of engagement, (5) Documentation and transparency, and (6) Conflict of interest management. In this paper, we discuss these issues and our plan to develop guidance to facilitate stakeholder engagement in all stages of the development of health and healthcare guideline development.
QEEG findings in adolescents complaining of headache
Authors: Elkholy Saly , Amer Hanan , Basheer Mye , Sabbah Asmaa 
Published: April 2023

AbstractBackgroundHeadache is one of the most common neurological symptoms reported in adolescence. The value of electroencephalography (EEG) in the diagnostics of patients with headache is controversial; however, quantitative EEG (QEEG) can clarify the pathophysiology of headache. Aim of the study was to assess QEEG and daily habits in adolescents with or without a clinical history of headache (according to answers of a screening questionnaire), to identify differences, attempt to explain them, and find possible correlations. This cross-sectional study included 89 adolescents; age 18–19 years at time of study, including 24 males. Headache was reported in 58 participant. All consenting subjects filled a questionnaire and underwent a conventional 30 min EEG examination. The mean frequency (Hz) and amplitude (µV) (absolute and relative) of beta (at F7and F8), theta (at C3 and C4), and alpha (at O1 and O2) band points were analyzed.ResultsA comparison of caffeine intake, and mobile phone use in cases versus controls showed no significant differences. QEEG showed statistically significant differences in the findings within alpha freq-O1, alpha freq-O2, and beta freq-F7 (P = 0.041, 0.003, and 0.05, respectively) in adolescents who had headache.ConclusionsThere were significant QEEG changes in the occipital regions and left frontal region in individuals with headache. It is recommended to perform more extensive statistical correlations between QEEG and clinical data should be targeted in future researches, to obtain a clearer view of the relationship between daily habits and the electrophysiology of headache.
Risk and prognostic factors in patients with congenital encephalocele
Authors: Mustafa Ahmed Mahmoud , AbdElaal Mohammed Ahmed , Almamoun Momen Mohamed , Saro Ahmed Salah Eldin , Ali Magda Mohamed 
Published: April 2023

Abstract
Background and objective
Encephaloceles are considered to be a spectrum of neural tube defects with a herniation of the brain and the meninges through a bony skull defect to the exterior.

Methods
This retrospective and prospective study was carried out on 30 patients with congenital encephaloceles either vault or basal. The risk factors and the prognostic factors were assessed.

Results
There was a statistically significant association between the content of the sac, outcome and seizures. There was a presence of neural tissue associated with worse outcome and seizures. There was a statistically significant association between the size of the sac and outcome with seizure. There was a statistically insignificant association between site of defect and parent consanguinity, folic acid intake, drug history, seizures, outcome, gender, family history and a statistically significant association between the site of the sac and hydrocephalus. There was a statistically significant association between the outcome and presence of Hydrocephalus, microcephaly and seizures.

Conclusions
There was statistically significant association between the worst outcome and presence of hydrocephalus, microcephaly and seizures, and there is correlation between site of the defect in occipitocervical region and development of hydrocephalus.
Touching Ash in Vietnamese Diasporic Aesthetics
Authors: Pham David 
Published: April 2023

AbstractWater has held a privileged place in theorizations of Vietnamese refugee being. Drawing from Ocean Vuong’s chapbook Burnings (2010) and novel On Earth We’re Briefly Gorgeous (2019) along with Tuan Andrew Nguyen’s film The Boat People (2020), this article traces an alternative genealogy of Vietnamese diasporic aesthetics based on the element of fire. Theorizing fire as another critical site of refugee passages, these works evince a pyric refugee onto-epistemology, one that conceives of fire and ash as explicit matter-metaphors of living and beauty that refuse the sensory diminution of racialized subjects as a result of US imperial and militaristic violence. Fire carries with it a destructive valence, and ash is taken as evidence of ruin and disaster. However, the explorations of fire and ash in both artists’ work not only attest to the various onto-epistemological unravelings signified by fire and ash but also conceive of the possibilities and openings for a refugee poiesis that emerges in the aftermath of destruction. Both Vuong and Nguyen stage haptic encounters with ash that wrestle with questions of sensation and subjectivity in the narration of personal and collective trauma. Paradoxically, these texts espouse the notion that any possibility of refugee futurity happens through contact with the subjunctive power of that which is insensible, ash.
Playing Pandemics
Authors: Gilbert Andrew L. 
Published: April 2023

Abstract
This essay analyzes the 2007 board game Pandemic in light of the COVID-19 global pandemic. The essay explores the connections between the reality of Pandemic and the play of COVID-19. To do this, it uses Ian Bogost’s interpretation of systems (both real and imagined) to invite a dialectic of reality and game simulation. The interaction of such systems, in a game whose theme became real, highlights a major tenet of game studies—the borders between reality and games are thin, blurred, and mobile, if they exist at all. Games, in their simulation of the real, are mimetic, and, in turn, reality has become gamified. The essay examines the board game and highlights its mechanics, which include cooperation and mitigation of risk. It also explores how the game and reality blur their borders in this instance of play, inviting further study into the ramifications of simulated games and the fantasy of the real.
Surface and Retreat
Authors: Zee Jerry 
Published: April 2023

Abstract
This essay is an experiment in figuring the pandemic through its reconfigurations of Chineseness. It departs from the Sinophobic cliché that conflates race, geopolitics, and epidemiology: the “China Virus” and its cloud of cognate slurs. It considers the slogan-slur as both an epithet and a conceptual and political challenge to imagine the pandemic as it is lived, still, as a disorientation of Asian and Asian American life, time, and death. The essay pauses at each of the three Lunar New Years of the pandemic, so far, to consider how Chineseness—as a national example, as a mode of racialization, and as a site of racial suspicion—might upset a US-based accounting of the pandemic, which frames it only through its arrival on American shores.
Fascist Culture, Critical Pedagogy, and Resistance in Pandemic Times
Authors: Giroux Henry A. 
Published: April 2023

Abstract
This essay offers an overview of the threats posed to our democratic and educational institutions by neoliberalism and neofascism and articulates a pedagogy of “educated hope” based on the work of Ernst Bloch, Paulo Freire, and James Baldwin to restore a sense of civic and democratic agency in the classroom and other public settings.
Orbitozygomatic Transsylvian and Subtemporal Transzygomatic Approaches for Clipping of Basilar Tip Aneurysms: 2-Dimensional Operative Video
Authors: Shenoy Varadaraya Satyanarayan , Sekhar Laligam N. 
Published: April 2023

INDICATIONS: CORRIDOR AND EXPOSURE:
The orbitozygomatic transsylvian approach is ideal for basilar tip aneurysms (BTAs) ≤15 mm located at or above the level of posterior clinoid process (PCP), whereas for larger, low-lying BTA's with fetal posterior cerebral artery (PCA), the subtemporal transzygomatic approach is preferred. Both approaches expose the basilar tip area and structures in the interpeduncular fossa from an anterolateral angle and the lateral angle, respectively.

ANATOMIC ESSENTIALS: NEED FOR PREOPERATIVE PLANNING AND ASSESSMENT:
Aneurysm size and level, brainstem perforators, and PCA size (fetal or not) should be noted preoperatively.

ESSENTIAL STEPS OF THE PROCEDURE:

A.
Orbitozygomatic transsylvian approach

1.
Frontotemporal craniotomy with posterolateral orbitotomy.

2.
Extradural optic nerve decompression and anterior clinoidectomy.

3.
Transsylvian dissection and carotid-optic cistern decompression.

4.
Distal dural ring opening.

5.
Aneurysm exposure and clipping.
Or

B.
Subtemporal transzygomatic approach
1

1.
Frontotemporal incision with zygomatic osteotomy.

2.
Temporal lobe retraction, subtemporal dissection, and tentorial division.

3.
Cavernous sinus opening and dorsum sellae drilling.

4.
Petrous apex resection.

5.
Aneurysm exposure and clipping.

PITFALLS/AVOIDANCE OF COMPLICATIONS:
Complications such as cranial nerve injury, perforator stroke, aneurysm rupture, and hemorrhage can be prevented by neuromonitoring, avoiding temporary basilar occlusion for >10 minutes, use of transient adenosine arrest during clipping, and interposing rubber dam between perforators and aneurysm.
1

VARIANTS AND INDICATIONS OF THEIR USE:
Cavernous sinus opening with posterior clinoidectomy and dorsum sellae drilling may be performed if aneurysm neck is at or below the level of PCP.
1-7

The patient consented to the procedure.
Potential of prospective medicinal plants of Rhizophoraceae from North Kalimantan, Indonesia
Authors: EGRA SAAT , KUSPRADINI HARLINDA , KUSUMA IRAWAN WIJAYA , BATUBARA IRMANIDA , IMRA IMRA , NURJANNAH NURJANNAH , WAHYUNI ETTY , YAMAUCHI KOSEI , MITSUNAGA TOHRU 
Published: April 2023

Abstract. Egra S, Kuspradini H, Kusuma IW, Batubara I, Imra, Nurjannah, Wahyuni E, Yamauchi K, Mitsunaga T. 2023. Potential of prospective medicinal plants of Rhizophoraceaefrom North Kalimantan, Indonesia. Biodiversitas 24: 1346-1355. The abundance of mangrove forests in the equatorial region necessitates proper management, including the sustainable use of plant parts for functional products such as food, medicine, etc. This study aimed to assess the medicinal potential of five mangrove plants through phytochemical analysis, antibacterial assays against Streptococcus sobrinus, DPPH free radicals, and toxicity assay using Artemia salina L., Bruguiera parviflora(Roxb.) Wight and Arn. ex Griff, Bruguiera cylindrica(L.) Blume, Ceriops tagal(Perr.). The plants used were Ceriops tagal (Perr.) C.B. Rob, Rhizophora mucronata Poir, and Rhizophora apiculata Blume. Plant samples were extracted with n-hexane, ethyl acetate, and methanol in that order, and then the obtained plant extracts were subjected to various assays. The results showed that B. cylindrica wood and C. tagal leaf extract had the highest antibacterial activity, with more than 50% relative inhibition. The C. tagal leaf methanolic extract had the highest antioxidant activity, by 91% relative inhibition. Followed by R. mucronata wood ethyl acetate extract and B. parviflora leaf methanolic extract, with 87% and 86%, respectively. The highest value in the cytotoxicity assay was discovered in the B. cylindrica in the very strong category with an LC50value of 22.9 µg/mL. The present study revealed the potential of mangrove plant extracts to have strong antibacterial, cytotoxic, and antioxidant properties.
Anti-spike protein to determine SARS-CoV-2 antibody levels: Is there a specific threshold conferring protection in immunocompromised patients?
Authors: Halfon Philippe , Jordana Sylvie , Blachier Stéphane , Cartlamy Philippe , Kbaier Laurent , Psomas Christina K. , Philibert Patrick , Antoniotti Gilles , Allemand-Sourrieu Julie , Rebaudet Stanislas , Cavaille Guilhem , Stavris Chloé , Retornaz Frédérique , Chiche Laurent , Penaranda Guillaume 
Published: April 2023

Background
Identifying a specific threshold level of SARS-CoV-2 antibodies that confers protection in immunocompromised patients has been very challenging. The aim was to assess the threshold of 264 binding antibody units (BAU)/ml using four different SARS-CoV-2 antibody assays (Abbott, Beckman, Roche, and Siemens) and to establish a new optimal threshold of protection for each of the four antibody assays.

Methods
This study was performed on data retrieved from 69 individuals, who received at least one dose of the Pfizer/BioNTech BNT162b2 or Moderna COVID-19 vaccine (Spikevax) at the Alphabio Laboratory in Marseille, France (European Hospital, Alphabio–Biogroup). The results were compared to the percent inhibition calculated using a functional surrogate of a standardized virus neutralization test (Genscript).

Results
Samples from 69 patients were analyzed. For a reference cutoff of 264 BAU/ml, assays showed moderate to good overall concordance with Genscript: 87% concordance for Abbott, 78% for Beckman, 75% for Roche, and 88% for Siemens. Overall concordance increased consistently after applying new thresholds, i.e., 148 BAU/ml (Abbott), 48 (Beckman), 559 (Roche), and 270 (Siemens).

Conclusion
We suggest specific adjusted thresholds (BAU/ml) for the four commercial antibody assays that are used to assess pre-exposure prophylaxis in immunocompromised patients.
“Life is a Gamble”
Authors: Reumert Anna 
Published: April 2023

This article foregrounds the returns of migration by following young migrant workers to Lebanon and back to subsistence farming communities in western Sudan during a time of revolution and economic crisis in both countries. Their labor and the returns of it connect these two seemingly distinct zones of labor and production in a transregional economy, linking East Africa to the Middle East. In this cross-border economy, the search for work through mobility has become a point of value extraction by brokers and border guards, and at the same time a practice of gendered self-validation for male migrants. In Sudan, migrants and brokers both refer to this practice as a gamble, mughamara. Proposing mughamara as an ethnographic concept of mobility, I show how young migrants use this term to validate themselves through migration. Comparing their experiences to Sudanese migrants who worked in Lebanon decades before them, I show how the youth’s presentation of mobility as a necessary gamble with life reveals an underlying generational experience of crisis and the foreclosure of class mobility. In a political and socioeconomic context where migrant workers often feel devalued in and by labor, mobility is presented as their only way forward—as well as their ticket home.
Front propagation in a double degenerate equation with delay
Authors: Bo Wei-Jian , Wu Shi-Liang , Du Li-Jun 
Published: April 2023

Abstract
The current article is concerned with the traveling fronts for a class of double degenerate equations with delay. We first show that the traveling fronts decay algebraically at one end, while those may decay exponentially or algebraically at the other end, which depend on the wave speed of traveling fronts. Based on the asymptotical behavior, the uniqueness and stability of traveling fronts are then proved. Of particular interest is the effect of the lower order term and higher order term on the critical speed. We mention that, under the double degenerate case, the nonlinear reaction is less competitive due to the appearance of degeneracy. This yields that the critical speed depends on the lower order term and higher order term, which is different from the nondegenerate case.
Effect of heat input on corrosion behavior of automotive zinc-coated steel joint
Authors: Khansole Ankush , Basak Sushovan , Pal T. K. , Shome M. 
Published: April 2023

Abstract
Lately, coated steel sheets have replaced bare steel in the automotive sectors due to their corrosion protection. Among them, zinc-coated high strength interstitial free (HIF) steel is widely used due to its durability, formability, good surface finish, impact resistance, and corrosion resistance. However, joining galvannealed (GA) steel using conventional fusion welding processes is challenging as it results in porosity and potentially harmful fumes. To overcome these challenges, this work uses a pulse MIG (metal inert gas) brazing technique to join the HIF-GA steel sheet with a lap joint configuration utilizing Cu-Si base filler wire (CuSi3Mn1) in an argon atmosphere. The study aims to evaluate the effect of heat input on bead geometry and Zn degradation in MIG brazed joints by adjusting the current from 40 to 60 A and brazing speed from 400 to 500 mm min−1. It is observed that the heat input is inversely proportional to the wetting angle and directly proportional to the bead width, leg length, and cross-sectional area. Heat input influences Zn degradation on both the front (at the toe) and back sides of the lap joint. The corrosion behavior of joints is studied using an electrochemical test (in 3.5% NaCl solution) and a salt spray test (in 5% NaCl solution). Further, the Zn degradation is analyzed with EDS line scanning to understand the corrosion resistance of the MIG brazed joints. A potentiostatic polarization study is also conducted to determine the corrosion rate using a Tafel plot. It is found that the lowest corrosion rate in base metal (BM) increased from 0.88 to 12.26 mm year−1 with the increase in heat input from 61 to 113 J mm−1.